Beginning of HMDB00001
# Accession_No:
HMDB00001

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-25 12:02:26

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
1-Methylhistidine

# Description:
One-methylhistidine (1-MHis) is derived mainly from the anserine of dietary flesh sources, especially poultry. The enzyme, carnosinase, splits anserine into b-alanine and 1-MHis. High levels of 1-MHis tend to inhibit the enzyme carnosinase and increase anserine levels. Conversely, genetic variants with deficient carnosinase activity in plasma show increased 1-MHis excretions when they consume a high meat diet. Reduced serum carnosinase activity is also found in patients with Parkinson's disease and multiple sclerosis and patients following a cerebrovascular accident. Vitamin E deficiency can lead to 1-methylhistidinuria from increased oxidative effects in skeletal muscle.

# Synonyms:
1 methylhistidine; 1-methyl histidine; 1-MHis; 1-Methyl-Histidine; 1-Methyl-L-histidine; 1-N-Methyl-L-histidine; L-1-Methylhistidine; N1-Methyl-L-histidine; pi-methylhistidine

# Chemical_IUPAC_Name:
(2S)-2-amino-3-(1-methylimidazol-4-yl)propanoic acid

# Chemical_Formula:
C7H11N3O2

# Chemical_Structure:
tbl_chemical:::HMDB00001_ZOOM.png:::119283121747288589

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00001_THUMB.png:::119283121537336922

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
alpha-aminoacid; aromatic compound; carboxylic acid; heterocyclic compound; primary aliphatic amine (alkylamine); primary amine

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
169.08511

# Molecular_Weight_Avg:
169.18114

# Smiles_String_isomeric:
CN1C=NC(C[C@H](N)C(O)=O)=C1

# Smiles_String_canonical:
CN1C=NC(CC(N)C(O)=O)=C1

# KEGG_Compound_ID:
C01152

# BioCyc_ID:
CPD-1823

# PubChem_CID:
92105

# PubChem_SID:
10225185; 14772557; 15171160; 206908; 4381; 668946; 8189415

# OMIM_ID:
212200

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Not Available

# METLIN_ID:
3741

# Ref_ID:
10362454; 7762816; 11052553; 2593832; 1819935; 2912013; 14156296; 7061274; 9478024; 15899597; 9029312; 1484110

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
332-80-9

# InChI:
InChI=1/C7H11N3O2/c1-10-3-5(9-4-10)2-6(8)7(11)12/h3-4,6H,2,8H2,1H3,(H,11,12)/t6-/m0/s1

# Synthesis_Reference:
Greenstein, J.P. et al., Chemistry of the Amino Acids, Wiley, N.Y., 1961, 3, 2763; Barlos, K. et al., Annalen, 1989, 387; Jain, R. et al., Tetrahedron, 1996, 52, 5363-5370

# Melting_Point:
246-248 oC

# Melting_Point_predicted:
92.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
6.93 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.8 [Predicted by PubChem via XLOGP]; -2.94 [Predicted by ALOGPS]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::1166125930.mol:::164198335751476

# SDF_File_[Text]:
tbl_chemical:::HMDB00001.sdf:::119283121196395808

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00001.pdb:::119283121396864392

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041031_P00_04_IS_1DP_presat.png:::114617840545472471

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041031_P00_04_IS_1DP_presat.zip:::114617840545868826

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041031_P00_04_IS_1DP_Assigned.png:::115627307937961123

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Not Available

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041031_P00_04_IS_2DHSQC_674.png:::114789597381635980

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041031_P00_04_IS_2DHSQC_674.zip:::114789597383999424

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041031_P00_04_IS_2DHSQC_674_Assigned.png:::114989116860249523

# Predicted_H_NMR_Spectrum:
tbl_chemical:::1-Methyl-Histidine.gif:::1132732097468759823

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00001_peaks.txt:::1155589605667826750

# Predicted_C_NMR_Spectrum:
tbl_chemical:::1-Methyl-Histidine_C.gif:::1132737652730893393

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00001_peaks.txt:::1155590384782746583

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00001_L.png:::119127187766612754; Medium Energy:tbl_ms:::HMDB00001_M.png:::119127187683633793>>>; High Energy:tbl_ms:::HMDB00001_H.png:::119127187849628912>>>

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Muscle; Skeletal Muscle;

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Cellular Cytoplasm; Saliva; Urine

# Concentration_[Normal]:
Urine	4.6 +/- 2.7	umol/mmol_creatinine	Adult:>18_yrs_old	Male	Normal	11052553
Urine	2.3 +/- 5.1	umol/mmol_creatinine	Adult:>18_yrs_old	Female	Normal	11052553
Urine	46.1 +/- 53.5	umol/mmol_creatinine	Adult:>18_yrs_old	Female	Normal	11052553
Urine	15.9 +/- 19.5	umol/mmol_creatinine	Adult:>18_yrs_old	Female	Normal	11052553
Urine	28.1 +/- 31.8	umol/mmol_creatinine	Adult:>18_yrs_old	Male	Normal	11052553
Urine	1.3 +/- 2.76	umol/mmol_creatinine	Adult:>18_yrs_old	Male	Normal	11052553
Urine	45.5 +/- 41.6	umol/mmol_creatinine	Adult:>18_yrs_old	Male	Normal	11052553
Urine	33.6 +/- 36.4	umol/mmol_creatinine	Adult:>18_yrs_old	Female	Normal	11052553
Blood	19.5 (0-39)	uM	Adult:>18_yrs_old	Both	Normal	7762816
Blood	19.44 +/- 14.93	uM	Adult:>18_yrs_old	Both	Normal	7061274 
Blood	9.1 +/- 7.2	umol/L	Children:1-13_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 85-97. Edited by Cornelius Lentner. ; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. ; Basle, Switzerland c1981-1992.
Blood	4.0 +/- 8.0	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 85-97. Edited by Cornelius Lentner. ; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. ; Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	4.0 +/- 1.74	uM	Adult:>18_yrs_old	Both	Normal	17031479
Saliva	26.34	uM	Adult:>18_yrs_old	Both	Normal	1819935
Cellular_Cytoplasm	2 - 156	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	15899597


# Concentration_[Abnormal]:
Cerebrospinal_Fluid(CSF)	2.6 +/- 1.13	uM	Adult:>18_yrs_old	Both	Alzheimer's Disease	17031479


# Associated_Disorders:
Alzheimer's Disease; Cachexia

# Pathway_Names:
Histidine Metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00340

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5713

# Metabolic_Enzyme_1_Name:
Beta-Ala-His dipeptidase precursor

# Metabolic_Enzyme_1_Synonyms:
Carnosine dipeptidase 1; CNDP dipeptidase 1; Serum carnosinase; Glutamate carboxypeptidase-like protein 2

# Metabolic_Enzyme_1_Gene_Name:
CNDP1

# Metabolic_Enzyme_1_Protein_Sequence:
>BetaAlaHis dipeptidase precursor
MDPKLGRMAASLLAVLLLLLERGMFSSPSPPPALLEKVFQYIDLHQDEFVQTLKEWVAIE
SDSVQPVPRFRQELFRMMAVAADTLQRLGARVASVDMGPQQLPDGQSLPIPPVILAELGS
DPTKGTVCFYGHLDVQPADRGDGWLTDPYVLTEVDGKLYGRGATDNKGPVLAWINAVSAF
RALEQDLPVNIKFIIEGMEEAGSVALEELVEKEKDRFFSGVDYIVISDNLWISQRKPAIT
YGTRGNSYFMVEVKCRDQDFHSGTFGGILHEPMADLVALLGSLVDSSGHILVPGIYDEVV
PLTEEEINTYKAIHLDLEEYRNSSRVEKFLFDTKEEILMHLWRYPSLSIHGIEGAFDEPG
TKTVIPGRVIGKFSIRLVPHMNVSAVEKQVTRHLEDVFSKRNSSNKMVVSMTLGLHPWIA
NIDDTQYLAAKRAIRTVFGTEPDMIRDGSTIPIAKMFQEIVHKSVVLIPLGAVDDGEHSQ
NEKINRWNYIEGTKLFAAFFLEMAQLH

# Metabolic_Enzyme_1_Number_of_Residues:
507

# Metabolic_Enzyme_1_Molecular_Weight:
56693

# Metabolic_Enzyme_1_Theoretical_pI:
4.95

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  protein dimerization activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  metallopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_1_Pathway:
map00340  Histidine metabolism;
 map00410  beta-Alanine metabolism

# Metabolic_Enzyme_1_Reaction:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF07687:M20_dimer;
PF01546:Peptidase_M20

# Metabolic_Enzyme_1_Signals:
1-26

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.4.13.20

# Metabolic_Enzyme_1_GenBank_ID_Protein:
16555792

# Metabolic_Enzyme_1_SwissProt_ID:
CNDP1_HUMAN (Q96KN2)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
CNDP1

# Metabolic_Enzyme_1_Geneatlas_id:
CNDP1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:20675

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_1_Gene_Sequence:
>1527 bp
ATGGATCCCAAACTCGGGAGAATGGCTGCGTCCCTGCTGGCTGTGCTGCTGCTGCTGCTG
CTGGAGCGCGGCATGTTCTCCTCACCCTCCCCGCCCCCGGCGCTGTTAGAGAAAGTCTTC
CAGTACATTGACCTCCATCAGGATGAATTTGTGCAGACGCTGAAGGAGTGGGTGGCCATC
GAGAGCGACTCTGTCCAGCCTGTGCCTCGCTTCAGACAAGAGCTCTTCAGAATGATGGCC
GTGGCTGCGGACACGCTGCAGCGCCTGGGGGCCCGTGTGGCCTCGGTGGACATGGGTCCT
CAGCAGCTGCCCGATGGTCAGAGTCTTCCAATACCTCCCGTCATCCTGGCCGAACTGGGG
AGCGATCCCACGAAAGGCACCGTGTGCTTCTACGGCCACTTGGACGTGCAGCCTGCTGAC
CGGGGCGATGGGTGGCTCACGGACCCCTATGTGCTGACGGAGGTAGGCGGGAAACTTTAT
GGACGAGGAGCGACCGACAACAAAGGCCCTGTCTTGGCTTGGATCAATGCTGTGAGCGCC
TTCAGAGCCCTGGAGCAAGATCTTCCTGTGAATATCAAATTCATCATTGAGGGGATGGAA
GAGGCTGGCTCTGTTGCCCTGGAGGAACTTGTGGAAAAAGAAAAGGACCGATTCTTCTCT
GGTGTGGACTACATTGTAATTTCAGATAACCTGTGGATCAGCCAAAGGAAGCTAGCAATC
ACTTACGGAACCCGGGGGAACAGCTACTTCATGGTGGAGGTGAAATGCAGAGACCAGGAT
TTTCACTCAGGAACCTTTGGTGGCATCCTTCATGAACTAATGGCTGATCTGGTTGCTCTT
CTCGGTAGCCTGGTAGACTCGTCTGGTCATATCCTGGTCCCTGGAATCTATGATGAAGTG
GTTCCTCTTACAGAAGAGGAAATAAATACATACAAAGCCATCCATCTAGACCTAGAAGAA
TACCGGAATAGCAGCCGGGTTGAGAAATTTCTGTTCGATACTAAGGAGGAGATTCTAATG
CACCTCTGGAGGTACCCATCTCTTTCTATTCATGGGATCGAGGGCGCGTTTGATGAGCCT
GGAACTAAAACAGTCATACCTGGCCGAGTTATAGGAAAATTTTCAATCCGTCTAGTCCCT
CACATGAATGTGTCTGCGGTGGAAAAACAGGTGACACGACATCTTGAAGATGTGTTCTCC
AAAAGAAATAGTTCCAACAAGATGGTTGTTTCCATGACTCTAGGACTACACCCGTGGATT
GCAAATATTGATGACACTCAGTATCTCGCAGCAAAAAGAGCGATCAGAACAGTGTTTGGA
ACAGAACCAGATATGATCCGGGATGGATCCACCATTCCAATTGCCAAAATGTTCCAGGAG
ATCGTCCACAAGAGCGTGGTGCTAATTCCGCTGGGAGCTGTTGATGATGGAGAACATTCG
CAGAATGAGAAAATCAACAGGTGGAACTACATAGAGGGAACCAAATTATTTGCTGCCTTT
TTCTTAGAGATGGCCCAGCTCCATTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AJ417564

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:18

# Metabolic_Enzyme_1_Locus:
18q22.3

# Metabolic_Enzyme_1_SNPs:
rs4263028; rs11151964; rs9807352; rs12960862; rs2887; rs4891564; rs2346064; rs1004453; rs7239132; rs12604675; rs10469123; rs10469203; rs12607796; rs12605490; rs8087768; rs9319909; rs4892246; rs7506171; rs4329999; rs7242384; rs8085167; rs11876996; rs7244370; rs7506929; rs4892243; rs7231312; rs4892242; rs12605520; rs733686; rs9967490; rs7229005; rs7232853; rs1426256; rs7506957; rs17817095; rs11875756; rs7506825; rs17817180; rs12961730; rs12964027; rs12456406; rs12964208; rs7506760; rs12956997; rs12456388; rs12964454; rs11873844; rs17817345; rs7505047; rs17089382; rs17089414; rs17089390; rs7233066; rs9953129; rs9960024; rs11659237; rs9807248; rs11662276; rs17816861; rs11873901; rs10469124; rs17089403; rs1559809; rs17817077; rs9949100; rs4891563; rs11661606; rs2881289; rs7228575; rs9957229; rs9955944; rs17089375; rs4892244; rs17089411; rs4892239; rs17238585; rs7505555; rs12326826; rs9946796; rs11876764; rs9949990; rs34570315; rs12957330; rs7506936; rs4892241; rs7506258; rs9952652; rs4355018; rs9957885; rs11664748; rs4133234; rs17238285; rs1974965; rs11659364; rs4892238; rs11875122; rs7237549; rs9948919; rs12959707; rs12457983; rs12964810; rs1974963; rs4891562; rs11873542; rs12962343; rs2881288; rs17089378; rs12954161; rs9959794; rs7504932; rs12327522; rs11664535; rs7230673; rs12455650; rs1974964; rs7244647; rs9989559; rs11875810; rs12954438; rs2098910; rs2346061; rs2346063; rs890333; rs2346062; rs2081548; rs890332; rs11538620; rs34522443; rs11538622; rs11538624; rs11538623; rs35604255; rs10533212; rs35771415; rs34713611; rs9967349; rs33922160; rs34365714; rs34526667; rs11875787; rs28448542; rs28871039; rs35084313; rs10549931; rs10685765; rs34874693; rs4891561; rs12606902; rs34117300; rs12959038; rs36228963; rs5826336; rs35735348; rs34499247; rs35885130; rs35388041; rs28713380; rs11151965; rs34138697; rs35204551; rs9966983; rs7505007; rs35096494; rs33950634; rs33981863; rs34142328; rs12959706; rs9955580; rs9947243; rs34869467; rs35788286; rs10624462; rs34283867; rs6566813; rs34962477; rs34335073; rs5826332; rs36060345; rs34573470; rs35682790; rs35362460; rs35860275; rs35365788; rs12964034; rs10522670; rs12959748; rs4892245; rs36111704; rs12969794; rs5826335; rs4891560; rs9965945; rs34070364; rs10624665; rs5826334; rs34842524; rs35877440; rs34785330; rs17089373; rs7233122; rs10596720; rs9948674; rs34189472; rs10562152; rs10649703; rs34321505; rs35707511; rs9949211; rs35368997; rs35691581; rs35734110; rs9953867; rs34563384; rs35469246; rs8087111; rs34726849; rs35932028; rs12969795; rs12969769; rs34799288; rs35234907; rs28800835; rs34646410; rs10685766; rs34895018; rs35597919; rs12961586; rs6566814; rs28877095; rs4892240; rs33911381; rs8088199; rs11872770; rs36206459; rs7350982; rs34145828; rs11447097; rs12104001; rs4892247; rs3080879; rs10663835; rs10871736; rs10871737; rs1130046; rs11664131; rs12327049; rs12456405; rs12954579; rs12966495; rs12967519; rs12970020; rs17089369; rs2114228; rs28534519; rs35248661; rs4353545; rs4891565; rs4891566; rs4892233; rs4892248; rs4892249; rs6566815; rs7238101; rs7504377; rs7506051; rs7506112; rs8096427; rs8099458; rs9319908

# Metabolic_Enzyme_1_General_References:
12975309

# Metabolic_Enzyme_1_References:
Not Available

End of HMDB00001

Beginning of HMDB00002
# Accession_No:
HMDB00002

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-04-23 14:46:09

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
1,3-Diaminopropane

# Description:
A stable, flammable and highly hydroscopic fluid.  It is a polyamine that is normally quite toxic if swallowed, inhaled or absorbed through the skin.  It is a catabolic byproduct of spermidine.  It is also a precursor in the enzymatic synthesis of beta-alanine.  1, 3-Diaminopropane is involved in the arginine/proline metabolic pathways and the beta-alanine metabolic pathway

# Synonyms:
1,3-Diamino-n-propane; 1,3-Propylenediamine; 1,3-Trimethylenediamine; 1,3-propanediamine; 3-Aminopropylamine; Propane-1,3-diamine; TMEDA; Trimethylenediamine; a,w-Propanediamine

# Chemical_IUPAC_Name:
propane-1,3-diamine

# Chemical_Formula:
C3H10N2

# Chemical_Structure:
tbl_chemical:::HMDB00002_ZOOM.png:::119283122643436833

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00002_THUMB.png:::119283122460553014

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Alkyl Amines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine)

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
74.08440

# Molecular_Weight_Avg:
74.12490

# Smiles_String_isomeric:
NCCCN

# Smiles_String_canonical:
NCCCN

# KEGG_Compound_ID:
C00986

# BioCyc_ID:
CPD-313

# PubChem_CID:
428

# PubChem_SID:
11369168; 3132683; 73856; 11366606; 2377; 10318372; 3753359; 3754956; 11361872; 11493717; 589747; 3736672; 7646949; 11341689; 11375626; 8145139; 10324013; 3754109; 151124; 11487274; 559277; 10503763; 4233; 7853333; 8150629; 11364044; 11494964; 11377330

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
36543

# Wikipedia_ID:
TMEDA

# METLIN_ID:
5081

# Ref_ID:
3757213; 9226558; 5096953; 1150841; 6324613; 293750; 8624793; 3308180; 6713628; 9464484

# ChEBI_ID:
15725

# CAS_Registry_Number:
109-76-2

# InChI:
InChI=1/C3H10N2/c4-2-1-3-5/h1-5H2

# Synthesis_Reference:
Putochin, N., Ber., 1926, 59, 625; Ing, H.R. et al., J.C.S., 1926, 2348; Aspinall, S.R., J.A.C.S., 1941, 63, 2843; Whitmore, F.C. et al., J.A.C.S., 1944, 66, 725-728

# Melting_Point:
-12 oC

# Melting_Point_predicted:
21.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
1000.0 mg/mL [MEYLAN,WM et al. (1996)]; 437.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
2

# State:
Liquid

# LogP:
-1.43 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-1.40 [Predicted by ALOGPS]; -1 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::1,3-Diaminopropane.pdf:::1132562188382464025

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::1,3-Diaminopropane.mol:::1132723680375540830

# SDF_File_[Text]:
tbl_chemical:::HMDB00002.sdf:::119283122141260173

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00002.pdb:::119283122287998934

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041107_P00_03_HW_1DP_noesy.png:::116890067225652158278

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041107_P00_03_HW_1DP_Presat.zip:::115514332651733031

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041107_P00_03_HW_1DP_Assigned.png:::115626695340649215

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041107_P00_03_HW_2DHSQC_744.png:::114789539537567341

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041107_P00_03_HW_2DHSQC_744.zip:::11478953954366596

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041107_P00_03_HW_2DHSQC_744_Assigned.png:::114989044946645182

# Predicted_H_NMR_Spectrum:
tbl_chemical:::1,3-Diaminopropane.gif:::1132732097734706016

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00002_peaks.txt:::1156309477880638625

# Predicted_C_NMR_Spectrum:
tbl_chemical:::1,3-Diaminopropane_C.gif:::113273765359215007

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00002_peaks.txt:::1156310670053882620

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00002L.png:::117555261802699271; Medium Energy:tbl_ms:::HMDB00002M.png:::117555266916363312; High Energy:tbl_ms:::HMDB00002H.png:::117555270802418922

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000001.png:::116890821476580881

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000001.txt:::116890821476521034

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000001.png:::116890821435959382

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000001.txt:::11689082147654173

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Urine

# Concentration_[Normal]:
Urine	2.55 (0.18-5.85)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9464484


# Concentration_[Abnormal]:
Urine	0.96 (0.12-2.11)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Cancer	9464484


# Associated_Disorders:
Cancer

# Pathway_Names:
Urea cycle and metabolism of amino groups

# Pathway_Images:
Urea_Cycle.jpg

# KEGG_Images:
map00220

# Pathway_Graphs:
Urea_Cycle_Graph.jpg

# Pathway_SBMLs:
Urea_Cycle.xml

# Metabolic_Enzyme_1_ID:
5451

# Metabolic_Enzyme_1_Name:
Deoxyhypusine synthase

# Metabolic_Enzyme_1_Synonyms:
DHS

# Metabolic_Enzyme_1_Gene_Name:
DHPS

# Metabolic_Enzyme_1_Protein_Sequence:
>Deoxyhypusine synthase
MEGSLEREAPAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQATNFG
RAVQQVNAMIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLV
QHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYCKFE
DWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVFSPALTDGS
LGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKCTGMIILGGGVVKHHIANANLMRNGA
DYAVYINTAQEFDGSDSGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQKMD
AFMHEKNED

# Metabolic_Enzyme_1_Number_of_Residues:
369

# Metabolic_Enzyme_1_Molecular_Weight:
40971

# Metabolic_Enzyme_1_Theoretical_pI:
5.02

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  peptidyl-amino acid modification
Process:  peptidyl-lysine modification
Process:  hypusine biosynthesis from peptidyl-lysine
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue

# Metabolic_Enzyme_1_Pathway:
Not Available

# Metabolic_Enzyme_1_Reaction:
[eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01916:DS

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.5.1.46

# Metabolic_Enzyme_1_GenBank_ID_Protein:
994715

# Metabolic_Enzyme_1_SwissProt_ID:
DHYS_HUMAN (P49366)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
DHPS

# Metabolic_Enzyme_1_Geneatlas_id:
DHPS

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2869

# Metabolic_Enzyme_1_PDB_ID:
1RQD

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1110 bp
ATGGAAGGTTCCCTGGAACGGGAGGCGCCAGCGGGGGCGCTGGCCGCCGTGCTAAAGCAC
AGCTCGACGTTGCCGCCCGAAAGCACCCAGGTCCGGGGCTACGACTTCAACCGCGGTGTG
AATTACCGCGCACTGCTGGAGGCCTTCGGCACCACCGGCTTCCAAGCAACCAACTTCGGG
CGCGCTGTACAGCAAGTCAATGCCATGATCGAGAAGAAGCTGGAACCACTGTCACAGGAT
GAAGACCAGCACGCGGACCTGACCCAGAGCCGCCGCCCACTTACCAGCTGCACCATTTTC
CTGGGATATACATCCAACCTCATCAGTTCAGGCATCCGTGAGACCATTCGCTACCTTGTG
CAGCACAACATGGTGGACGTATTGGTGACCACAGCTGGCGGCGTGGAGGAAGACCTCATC
AAGTGCCTGGCGCCCACATACTTGGGCGAGTTTAGCCTCAGGGGGAAGGAGCTCCGGGAG
AACGGGATCAATAGGATCGGAAACCTGCTGGTGCCCAATGAGAATTACTGCAAGTTTGAG
GACTGGCTGATGCCCATTCTGGACCAGATGGTGATGGAGCAGAACACAGAGGGTGTAAAG
TGGACGCCTTCTAAGATGATCGCCCGGCTGGGCAAGGAGATCAACAACCCAGAGTCCGTG
TATTACTGGGCCCAGAAGAACCACATCCCTGTGTTTAGTCCCGCACTTACAGACGGCTCG
CTGGGCGACATGATCTTCTTCCATTCCTACAAGAACCCGGGCCTGGTCCTGGACATCGTT
GAGGACCTGAGGCTCATCAACACACAGGCCATCTTTGCCAAGTGCACTGGGATGATCATT
CTGGGCGGGGGCGTGGTCAAGCACCACATTGCCAATGCCAACCTCATGCGGAACGGGGCC
GACTACGCTGTTTACATCAACACAGCCCAGGAGTTTGATGGCTCTGACTCAGGTGCCCGA
CCAGACGAGGCTGTCTCCTGGGGCAAGATCCGGGTGGATGCACAGCCCGTCAAGGTCTAT
GCTGACGCCTCCCTGGTCTTCCCCCTGCTTGTGGCTGAAACCTTTGCCCAGAAGATGGAT
GCCTTCATGCATGAGAAGAACGAGGACTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
L39068

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_1_Locus:
19p13.2-p13.1

# Metabolic_Enzyme_1_SNPs:
rs10425108; rs34700558; rs35129924; rs10414020; rs11879732; rs8110996; rs8109945; rs8111830; rs11882854; rs34610671; rs1050609; rs9517; rs11541390; rs3177932; rs1050613; rs1050610; rs36111604; rs1050615; rs1050612; rs34635891; rs34824552; rs28472346; rs28758673; rs12461822; rs10420931; rs10426729; rs28666561; rs1002339; rs10410027; rs10414810; rs10417588; rs1053292; rs1053805; rs1054367; rs12609451; rs12976109; rs1376645; rs14343; rs3178210; rs3209404; rs34203441; rs34373915; rs35092999; rs7250744; rs7254207; rs7255750; rs7256839; rs7258212

# Metabolic_Enzyme_1_General_References:
7673224; 8549832; 8615810; 9666110; 9110174; 7750572; 9493264

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5631

# Metabolic_Enzyme_2_Name:
Retina-specific copper amine oxidase precursor

# Metabolic_Enzyme_2_Synonyms:
RAO; Amine oxidase [copper-containing]

# Metabolic_Enzyme_2_Gene_Name:
AOC2

# Metabolic_Enzyme_2_Protein_Sequence:
>Retinaspecific copper amine oxidase precursor
MHLKIVLAFLALSLITIFALAYVLLTSPGGSSQPPHCPSVSHRAQPWPHPGQSQLFADLS
REELTAVMRFLTQRLGPGLVDAAQAQPSDNCIFSVELQLPPKAAALAHLDRGSPPPAREA
LAIVLFGGQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLRAEFTQMWRHLK
EVELPKAPIFLSSTFNYNGSTLAAVHATPRGLRSGDRATWMALYHNISGVGLFLHPVGLE
LLLDHRALDPAHWTVQQVFYLGHYYADLGQLEREFKSGRLEVVRVPLPPPNGASSLRSRN
SPGPLPPLQFSPQGSQYSVQGNLVVSSLWSFTFGHGVFSGLRIFDVRFQGERIAYEVSVQ
ECVSIYGADSPKTMLTRYLDSSFGLGRNSRGLVRGVDCPYQATMVDIHILVGKGAVQLLP
GAVCVFEEAQGLPLRRHHNYLQNHFYGGLASSALVVRSVSSVGNYDYIWDFVLYPNGALE
GRVHATGYINTAFLKGGEEGLLFGNRVGERVLGTVHTHAFHFKLDLDVAGLKNWVVAEDV
VFKPVAAPWNPEHWLQRPQLTRQVLGKEDLTAFSLGSPLPRYLYLASNQTNAWGHQRGYR
IQIHSPLGIHIPLESDMERALSWGRYQLVVTQRKEEESQSSSIYHQNDIWTPTVTFADFI
NNETLLGEDLVAWVTASFLHIPHAEDIPNTVTLGNRVGFLLRPYNFFDEDPSIFSPGSVY
FEKGQDAGLCSINPVACLPDLAACVPDLPPFSYHGF

# Metabolic_Enzyme_2_Number_of_Residues:
756

# Metabolic_Enzyme_2_Molecular_Weight:
83674

# Metabolic_Enzyme_2_Theoretical_pI:
7.03

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_2_Specific_Function:
May be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine

# Metabolic_Enzyme_2_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_2_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_2_Signals:
1-32

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1906806

# Metabolic_Enzyme_2_SwissProt_ID:
AOC2_HUMAN (O75106)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
AOC2

# Metabolic_Enzyme_2_Geneatlas_id:
AOC2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:549

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Membrane

# Metabolic_Enzyme_2_Gene_Sequence:
>2190 bp
ATGCATCTCAAGATAGTCCTGGCGTTCCTGGCACTGTCCCTCATTACCATCTTTGCCCTG
GCCTATGTTTTGCTGACCAGCCCAGGTGGTTCCAGCCAGCCTCCCCACTGCCCCTCTGTA
TCCCATAGGGCCCAGCCCTGGCCACACCCTGGCCAGAGCCAGCTGTTTGCAGACCTGAGC
CGAGAGGAGTTGACAGCTGTGATGCGCTTTCTGACCCAGCGGCTGGGGCCAGGGCTGGTG
GACGCAGCCCAGGCTCAGCCCTCGGACAACTGCATCTTCTCAGTGGAGCTGCAGCTGCCC
CCCAAGGCTGCAGCCCTGGCCCACCTGGACAGGGGGAGCCCCCCACCTGCCCGGGAGGCA
CTGGCCATCGTCCTCTTTGGTGGACAACCCCAACCCAATGTGAGTGAGCTGGTGGTGGGG
CCGCTGCCTCACCCCTCGTACATGCGGGATGTGACTGTGGAGCGTCACGGCGGGCCCCTG
CCCTATCACCGTCGCCCGGTGCTGAGAGCTGAGTTTACACAGATGTGGAGGCATCTGAAA
GATGTGGAGCTACCCAAGGCACCCATCTTCCTGTCGTCCACCTTCAACTACAATGGCTCT
ACCCTGGCAGCTGTGCATGCCACCCCTCGGGGCTTGCGCTCAAGGGAACGAACTACCTGG
ATTGGCCTCTACCATAACATCTCAGGGGTTGGTCTTTTCCTTCACCCCGTGGGGCTGGAG
CTACTACTGGACCACAGGGCCCTGGACCCTGCCCACTGGACTGTCCAGCAGGTCTTCTAC
CTTGGGCACTACTATGCAGACTTGGGCCAGTTGGAACGGGAGTTTAAGTCTGGCCGGTTG
GAAGTGGTTAGAGTCCCTCTACCTCCACCAAATGGAGCTTCATCCCTGAGGTCTCGGAAC
TCTCCAGGTCCTCTTCCCCCTCTTCAGTTCTCGCCCCAGGGTTCCCAGTACAGTGTGCAA
GGAAACCTGGTGGTATCCTCCCTCTGGTCATTTACCTTTGGCCATGGGGTGTTCAGCGGC
CTGAGGATTTTTGATGTTCGGTTCCAGGGTGAGCGAATAGCCTATGAAGTCAGTGTCCAG
GAGTGTGTATCTATCTATGGTGCCGATTCACCCAAGACGATGCTGACTCGCTATTTGGAT
AGCAGCTTTGGACTCGGCCGTAACAGCCGAGGCTTGGTGCGGGGAGTGGACTGCCCCTAT
CAAGCCACGATGGTGGACATCCATATATTAGTGGGCAAAGGGGCAGTCCAGCTGCTTCCA
GGGGCTGTGTGTGTATTTGAGGAAGCCCAGGGACTGCCCCTTCGAAGGCACCACAATTAC
CTTCAAAATCATTTCTATGGTGGTTTGGCCAGCTCAGCCCTTGTGGTCAGGTCTGTGTCA
TCTGTGGGCAACTATGACTACATTTGGGACTTTGTGTTGTACCCAAATGGGGCACTTGAA
GGGCGGGTCCATGCCACGGGTTATATCAACACAGCTTTCCTGAAAGGGGGAGAGGAGGGC
CTCCTCTTTGGGAACCGTGTGGGGGAAAGAGTGCTGGGAACGGTGCACACACATGCCTTC
CACTTCAAGCTGGACCTGGATGTGGCAGGGCTGAAAAACTGGGTGGTAGCTGAAGACGTG
GTGTTTAAACCTGTGGCTGCCCCCTGGAACCCGGAGCACTGGCTACAGCGCCCACAGCTG
ACTCGGCAGGTCCTGGGAAAGGAGGACCTGACAGCTTTTTCCTTGGGAAGCCCCCTACCC
CGCTACCTCTACCTGGCTAGCAACCAGACTAATGCGTGGGGTCACCAGCGCGGATACCAG
CTTGTGGTGACCCAGAGAAAGGAGGAGGAGTCACAGAGCAGTAGCATCTATCACCAGAAT
GACATCTGGACACCCACAGTTACCTTTGCTGACTTCATCAACAATGAAACCCTCTTAGGA
GAGGATCTGGTGGCTTGGGTCACAGCCAGCTTCCTGCACATTCCCCATGCCGAGGACATC
CCAAACACAGTGACTCTGGGGAACAGAGTTGGCTTCTTGCTCCGACCCTATAACTTCTTT
GATGAGGACCCCTCCATCTTCTCCCCTGGCAGTGTGTACTTTGAGAAGGGCCAGGATGCT
GGGCTCTGCAGCATCAATCCTGTGGCCTGCCTCCCCGACCTGGCAGCCTGTGTCCCGGAC
TTACCCCCTTTCTCTTACCACGGCTTCTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
D88213

# Metabolic_Enzyme_2_Chromosome_Location:
Not Available

# Metabolic_Enzyme_2_Locus:
Not Available

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
9119395; 9722954

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5630

# Metabolic_Enzyme_3_Name:
Membrane copper amine oxidase

# Metabolic_Enzyme_3_Synonyms:
Semicarbazide-sensitive amine oxidase; SSAO; Vascular adhesion protein 1; VAP-1; HPAO

# Metabolic_Enzyme_3_Gene_Name:
AOC3

# Metabolic_Enzyme_3_Protein_Sequence:
>Membrane copper amine oxidase
MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVW
AEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHP
RGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDF
SDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSA
DSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN

# Metabolic_Enzyme_3_Number_of_Residues:
763

# Metabolic_Enzyme_3_Molecular_Weight:
84623

# Metabolic_Enzyme_3_Theoretical_pI:
6.51

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_3_Specific_Function:
Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity

# Metabolic_Enzyme_3_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_3_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_3_Signals:
1-19

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1399032

# Metabolic_Enzyme_3_SwissProt_ID:
AOC3_HUMAN (Q16853)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
AOC3

# Metabolic_Enzyme_3_Geneatlas_id:
AOC3

# Metabolic_Enzyme_3_hgnc_id:
HGNC:550

# Metabolic_Enzyme_3_PDB_ID:
1PU4

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_3_Gene_Sequence:
>2292 bp
ATGAACCAGAAGACAATCCTCGTGCTCCTCATTCTGGCCGTCATCACCATCTTTGCCTTG
GTTTGTGTCCTGCTGGTGGGCAGGGGTGGAGATGGGGGTGAACCCAGCCAGCTTCCCCAT
TGCCCCTCTGTATCTCCCAGTGCCCAGCCTTGGACACACCCTGGCCAGAGCCAGCTGTTT
GCAGACCTGAGCCGAGAGGAGCTGACGGCTGTGATGCGCTTTCTGACCCAGCGGCTGGGG
CCAGGGCTGGTGGATGCAGCCCAGGCCCGGCCCTCGGACAACTGTGTCTTCTCAGTGGAG
TTGCAGCTGCCTCCCAAGGCTGCAGCCCTGGCTCACTTGGACAGGGGGAGCCCCCCACCT
GCCCGGGAGGCACTGGCCATCGTCTTCTTTGGCAGGCAACCCCAGCCCAACGTGAGTGAG
CTGGTGGTGGGGCCACTGCCTCACCCCTCCTACATGCGGGACGTGACTGTGGAGCGTCAT
GGAGGCCCCCTGCCCTATCACCGACGCCCCGTGCTGTTCCAAGAGTACCTGGACATAGAC
CAGATGATCTTCAACAGAGAGCTGCCCCAGGCTTCTGGGCTTCTCCACCACTGTTGCTTC
TACAAGCACCGGGGACGGAACCTGGTGACAATGACCACGGCTCCCCGTGGTCTGCAATCA
GGGGACCGGGCCACCTGGTTTGGCCTCTACTACAACATCTCGGGCGCTGGGTTCTTCCTG
CACCACGTGGGCTTGGAGCTGCTAGTGAACCACAAGGCCCTTGACCCTGCCCGCTGGACT
ATCCAGAAGGTGTTCTATCAAGGCCGCTACTACGACAGCCTGGCCCAGCTGGAGGCCCAG
TTTGAGGCCGGCCTGGTGAATGTGGTGCTGATCCCAGACAATGGCACAGGTGGGTCCTGG
TCCCTGAAGTCCCCTGTGCCCCCGGGTCCAGCTCCCCCTCTACAGTTCTATCCCCAAGGC
CCCCGCTTCAGTGTCCAGGGAAGTCGAGTGGCCTCCTCACTGTGGACTTTCTCCTTTGGC
CTCGGAGCATTCAGTGGCCCAAGGATCTTTGACGTTCGCTTCCAAGGAGAAAGACTAGTT
TATGAGATAAGCCTCCAAGAGGCCTTGGCCATCTATGGTGGAAATTCCCCAGCAGCAATG
ACGACCCGCTATGTGGATGGAGGCTTTGGCATGGGCAAGTACACCACGCCCCTGACCCGT
GGGGTGGACTGCCCCTACTTGGCCACCTACGTGGACTGGCACTTCCTTTTGGAGTCCCAG
GCCCCCAAGACAATACGTGATGCCTTTTGTGTGTTTGAACAGAACCAGGGCCTCCCCCTG
CGGCGACACCACTCAGATCTCTACTCGCACTACTTTGGGGGTCTTGCGGAAACGGTGCTG
GTCGTCAGATCTATGTCCACCTTGCTCAACTATGACTATGTGTGGGATACGGTCTTCCAC
CCCAGTGGGGCCATAGAAATACGATTCTATGCCACGGGCTACATCAGCTCGGCATTCCTC
TTTGGTGCTACTGGGAAGTACGGGAACCAAGTGTCAGAGCACACCCTGGGCACGGTCCAC
ACCCACAGCGCCCACTTCAAGGTGGATCTGGATGTAGCAGGACTGGAGAACTGGGTCTGG
GCCGAGGATATGGTCTTTGTCCCCATGGCTGTGCCCTGGAGCCCTGAGCACCAGCTGCAG
AGGCTGCAGGTGACCCGGAAGCTGCTGGAGATGGAGGAGCAGGCCGCCTTCCTCGTGGGA
AGCGCCACCCCTCGCTACCTGTACCTGGCCAGCAACCACAGCAACAAGTGGGGTCACCCC
CGGGGCTACCGCATCCAGATGCTCAGCTTTGCTGGAGAGCCGCTGCCCCAAAACAGCTCC
ATGGCGAGAGGCTTCAGCTGGGAGAGGTACCAGCTGGCTGTGACCCAGCGGAAGGAGGAG
GAGCCCAGTAGCAGCAGCGTTTTCAATCAGAATGACCCTTGGGCCCCCACTGTGGATTTC
AGTGACTTCATCAACAATGAGACCATTGCTGGAAAGGATTTGGTGGCCTGGGTGACAGCT
GGTTTTCTGCATATCCCACATGCAGAGGACATTCCTAACACAGTGACTGTGGGGAACGGC
GTGGGCTTCTTCCTCCGACCCTATAACTTCTTTGACGAAGACCCCTCCTTCTACTCTGCC
GACTCCATCTACTTCCGAGGGGACCAGGATGCTGGGGCCTGCGAGGTCAACCCCCTAGCT
TGCCTGCCCCAGGCTGCTGCCTGTGCCCCCGACCTCCCTGCCTTCTCCCACGGGGGCTTC
TCTCACAACTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U39447

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
8972912; 9653080

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5627

# Metabolic_Enzyme_4_Name:
Amiloride-sensitive amine oxidase [copper-containing] precursor

# Metabolic_Enzyme_4_Synonyms:
Diamine oxidase; DAO; Amiloride-binding protein; ABP; Histaminase; Kidney amine oxidase; KAO

# Metabolic_Enzyme_4_Gene_Name:
ABP1

# Metabolic_Enzyme_4_Protein_Sequence:
>Amiloridesensitive amine oxidase coppercontaining precursor
MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS
TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP
GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR
CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG
KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP
RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG
GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE
MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH
ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT
NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSM
ADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWDPPVVFEQFLHNNENI
ENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRD
NGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV

# Metabolic_Enzyme_4_Number_of_Residues:
751

# Metabolic_Enzyme_4_Molecular_Weight:
85342

# Metabolic_Enzyme_4_Theoretical_pI:
7.01

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function

# Metabolic_Enzyme_4_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_4_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_4_Signals:
1-19

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_4_GenBank_ID_Protein:
177960

# Metabolic_Enzyme_4_SwissProt_ID:
ABP1_HUMAN (P19801)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
ABP1

# Metabolic_Enzyme_4_Geneatlas_id:
ABP1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:80

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_4_Gene_Sequence:
>2142 bp
ATGCCGGCCCTGGGCTGGGCCGTGGCTGCCATCCTGATGCTGCAGACGGCCATGGCGGAG
CCCTCCCCGGGGACTCTGCCCAGGAAGGCAGGGGTGTTTTCAGACCTAAGCAACCAAGAG
CTGAAGGCAGTGCACAGCTTCCTCTGGTCCAAGAAGGAGCTGAGGCTGCAGCCCTCCAGT
ACCACCACCATGGCCAAGAACACCGTGTTTCTCATCGAGATGCTGCTGCCCAAGAAGTAC
CATGTGCTGAGGTTTCTGGATAAAGGTGAAAGGCATCCTGTGCGGGAAGCCCGTGCCGTC
ATCTTCTTTGGTGACCAGGAGCATCCCAATGTCACCGAGTTTGCTGTGGGGCCCCTGCCA
GGGCCCTGCTACATGCGAGCACTGTCCCCCAGGCCTGGGTACCAGTCCTCCTGGGCATCG
AGGCCCATCTCCACAGCAGAGTATGCCCTCCTCTACCACACCCTGCAGGAAGCCACCAAG
CCCCTGCATCAGTTCTTCCTCAATACCACAGGCTTCTCATTCCAAGACTGCCATGACAGA
TGCCTGGCCTTCACCGATGTGGCCCCCCGGGGTGTGGCTTCTGGCCAGCGCCGCAGTTGG
CTTATCATACAGCGCTATGTAGAAGGCTACTTTCTGCACCCCACTGGGCTGGAGCTCCTC
GTGGATCATGGGAGCACAGATGCTGGGCACTGGGCCGTGGAGCAGGTGTGGTACAACGGG
AAGTTCTATGGGAGCCCAGAGGAACTGGCACGGAAGTATGCAGATGGAGAGGTGGACGTG
GTGGTCCTGGAGGACCGCTGCCTGGGGGCAAGGGGCATGACAGCACAGAGGAGCCGGCCC
TCTTCTCCTCCACAAGCCCCGCGGGACTTTCCCCAGCCCCATCCATGTGAGCGGCCCCCG
CTTGGTCCAGCCCCACGGCCCTCGCTTCAGGCTGGAGGGCAACGCTGTGCTCTACGGCGG
CTGGAGCTTTGCCTTCCGGTGCGCTCCTCCTCCGGGCTGCAGGTCCTGAACGTGCACTTC
GGCGGAGAGCGCATTGCCTATGAGGTCAGCGTGCAAGAGGCAGTGGCGCTGTATGGAGGA
CACACACCTGCAGGCATGCAGACCAAGTACCTCGATGTCGGCTGGGGCCTGGGCAGCGTC
ACTCATGAGTTAGCCCCCGGCATCGACTGCCCGGAGACCGCCACCTTCCTGGACACTTTC
CACTACTATGATGCCGATGACCCGGTCCATTATCCCCGAGCCCTCTGCCTCTTTGAAATG
CCCACAGGGGTGCCCCTTCGGCGGCACTTTAATTCCAACTTTAAAGGTGGCTTCAACTTC
TATGCAGGGCTGAAGGGCCAGGTGCTGGTGCTGCGGACAACTTCAACTGTCTACAATTAT
GATTACATTTGGGACTTTATCTTCTACCCCAACGGGGTGATGGAGGCCAAGATGCATGCC
ACTGGCTACGTCCACGCCACCTTCTACACCCCCGAGGGCTGCGCACGGCACTCGCCTGCA
CACCCACCTGATTGGCAACATACACACTCACTTGTGCACTACCGCGTAGACCTGGATGTG
GCAGGCACCAAGAACAGCTTCCAGACACTGCAGATGAAGCTAGAAAACATCACCAACCCC
TGGAGCCCGAGACACCGCGTGGTCCAGCCAACTCTGGAGCAGACGCAGTACTCCTGGGAG
CGCCAGGCGGCCTTCCGCTTCAAAAGGAGGCTGCCCAAGTACCTGCTCTTTACCAGCCCC
CAGGAGAACCCCTGGGGCCACAAGCGCAGCTACCGCCTGCAGATCCACTCCATGGCCGAC
CAGGTGCTGCCCCCAGGCTGGCAGGAGGAGCAGGCCATCACCTGGGCAAGGTACCCCCTG
GCAGTGACCAAGTACCGGGAGTCAGAGCTGTGCAGCAGCAGCATCTACCACCAGAACGAC
CCCTGGGACCCGCCCGTGGTCTTTGAGCAGTTTCTTCACAACAACGAGAACATTGAAAAT
GAGGACCTGGTGGCCTGGGTGACGGTGGGCTTCCTGCACATCCCCCACTCAGAGGACATT
CCCAACACAGCCACACCTGGGAACTCCGTGGGCTTCCTGCTCCGGCCATTCAACTTCTTC
CCAGAGGACCCCTCCCCTCCCTGGCATCCAGAGACACTGTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M55602

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_4_Locus:
7q34-q36

# Metabolic_Enzyme_4_SNPs:
rs10156191; rs1049742; rs35070995; rs1049793; rs1049748; rs10893; rs2071514; rs4725373; rs10441169; rs2268998; rs2071513; rs10156189; rs2268999; rs7786439; rs12539; rs12540862; rs11771771; rs2071515; rs11981415; rs11981217; rs3735076; rs10952294; rs4725968; rs2301257; rs2373876; rs10273373; rs2052130; rs2052129; rs2071517; rs17173645; rs2301256; rs4725375; rs4725970; rs35929142; rs6943147; rs41465145; rs6943420; rs10441176; rs7787074; rs7786420; rs7786526; rs35730790; rs10281706; rs35773682; rs8180720; rs13235597; rs13235592; rs13235484; rs34532106; rs4725969; rs4725374; rs4431514; rs35724462; rs10273148; rs34459590; rs34090933; rs35411492; rs34502771; rs1005389; rs1005390; rs10230025; rs10236489; rs10240738; rs10249948; rs10250599; rs10250704; rs10254616; rs10254802; rs10268640; rs11760854; rs11771001; rs11971392; rs11976328; rs11978239; rs12374688; rs12374823; rs12375106; rs1476867; rs2215563; rs2215564; rs4725376; rs4725377; rs4725971; rs6977081; rs6977381; rs7793572; rs7798657; rs887587; rs887588

# Metabolic_Enzyme_4_General_References:
2217167; 8182053; 8595053; 8144586

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
6322

# Metabolic_Enzyme_5_Name:
Ornithine decarboxylase

# Metabolic_Enzyme_5_Synonyms:
ODC

# Metabolic_Enzyme_5_Gene_Name:
ODC1

# Metabolic_Enzyme_5_Protein_Sequence:
>Ornithine decarboxylase
MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP
RVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQI
KYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLL
LERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPG
SEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQ
TGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTC
DGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQF
QNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV

# Metabolic_Enzyme_5_Number_of_Residues:
461

# Metabolic_Enzyme_5_Molecular_Weight:
51149

# Metabolic_Enzyme_5_Theoretical_pI:
4.88

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  polyamine metabolism
Process:  polyamine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
L-ornithine = putrescine + CO(2)

# Metabolic_Enzyme_5_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_5_Reaction:
L-ornithine = putrescine + CO2

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF02784:Orn_Arg_deC_N;
PF00278:Orn_DAP_Arg_deC

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 4.1.1.17

# Metabolic_Enzyme_5_GenBank_ID_Protein:
29893806

# Metabolic_Enzyme_5_SwissProt_ID:
DCOR_HUMAN (P11926)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ODC1

# Metabolic_Enzyme_5_Geneatlas_id:
ODC1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:8109

# Metabolic_Enzyme_5_PDB_ID:
1D7K

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Not Available

# Metabolic_Enzyme_5_Gene_Sequence:
>1386 bp
ATGAACAACTTTGGTAATGAAGAGTTTGACTGCCACTTCCTCGATGAAGGTTTTACTGCC
AAGGACATTCTGGACCAGAAAATTAATGAAGTTTCTTCTTCTGATGATAAGGATGCCTTC
TATGTGGCAGACCTGGGAGACATTCTAAAGAAACATCTGAGGTGGTTAAAAGCTCTCCCT
CGTGTCACCCCCTTTTATGCAGTCAAATGTAATGATAGCAAAGCCATCGTGAAGACCCTT
GCTGCTACCGGGACAGGATTTGACTGTGCTAGCAAGACTGAAATACAGTTGGTGCAGAGT
CTGGGGGTGCCTCCAGAGAGGATTATCTATGCAAATCCTTGTAAACAAGTATCTCAAATT
AAGTATGCTGCTAATAATGGAGTCCAGATGATGACTTTTGATAGTGAAGTTGAGTTGATG
AAAGTTGCCAGAGCACATCCCAAAGCAAAGTTGGTTTTGCGGATTGCCACTGATGATTCC
AAAGCAGTCTGTCGTCTCAGTGTGAAATTCGGTGCCACGCTCAGAACCAGCAGGCTCCTT
TTGGAACGGGCGAAAGAGCTAAATATCGATGTTGTTGGTGTCAGCTTCCATGTAGGAAGC
GGCTGTACCGATCCTGAGACCTTCGTGCAGGCAATCTCTGATGCCCGCTGTGTTTTTGAC
ATGGGGGCTGAGGTTGGTTTCAGCATGTATCTGCTTGATATTGGCGGTGGCTTTCCTGGA
TCTGAGGATGTGAAACTTAAATTTGAAGAGATCACCGGCGTAATCAACCCAGCGTTGGAC
AAATACTTTCCGTCAGACTCTGGAGTGAGAATCATAGCTGAGCCCGGCAGATACTATGTT
GCATCAGCTTTCACGCTTGCAGTTAATATCATTGCCAAGAAAATTGTATTAAAGGAACAG
ACGGGCTCTGATGACGAAGATGAGTCGAGTGAGCAGACCTTTATGTATTATGTGAATGAT
GGCGTCTATGGATCATTTAATTGCATACTCTATGACCACGCACATGTAAAGCCCCTTCTG
CAAAAGAGACCTAAACCAGATGAGAAGTATTATTCATCCAGCATATGGGGACCAACATGT
GATGGCCTCGATCGGATTGTTGAGCGCTGTGACCTGCCTGAAATGCATGTGGGTGATTGG
ATGCTCTTTGAAAACATGGGCGCTTACACTGTTGCTGCTGCCTCTACGTTCAATGGCTTC
CAGAGGCCGACGATCTACTATGTGATGTCAGGGCCTGCGTGGCAACTCATGCAGCAATTC
CAGAACCCCGACTTCCCACCCGAAGTAGAGGAACAGGATGCCAGCACCCTGCCTGTGTCT
TGTGCCTGGGAGAGTGGGATGAAACGCCACAGAGCAGCCTGTGCTTCGGCTAGTATTAAT
GTGTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M16650

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_5_Locus:
2p25

# Metabolic_Enzyme_5_SNPs:
rs1804032; rs1049500; rs28362407; rs7558559; rs6738288; rs2302616; rs12616336; rs10490728; rs7608353; rs2302615; rs2430422; rs28362392; rs3771117; rs6753098; rs2302613; rs28362393; rs28364601; rs11538365; rs28362383; rs28362418; rs10490729; rs28362390; rs2302614; rs28362376; rs28362380; rs28362391; rs28362379; rs28362389; rs1405948; rs3752661; rs3832141; rs7559979; rs28362402; rs2357550; rs28362416; rs28362405; rs28362400; rs28362396; rs28362395; rs7599144; rs13396481; rs6708087; rs28362406; rs2009741; rs16856239; rs7609174; rs818162; rs28362433; rs28742580; rs28362424; rs28362432; rs28362425; rs28362431; rs28362434; rs28362422; rs28362429; rs28362370; rs28362423; rs28362428; rs11538369; rs11538368; rs28362411; rs11538363; rs28362397; rs28362381; rs34562944; rs7558222; rs28362374; rs28362417; rs28362385; rs34211053; rs28362372; rs3036408; rs28362386; rs34885558; rs34608521; rs14589; rs28362384; rs28362378; rs5829265; rs34007534; rs28362388; rs28362387; rs35128000; rs11538367; rs34145750; rs13401475; rs28362377; rs35616112; rs28362408; rs28362398; rs28362399; rs28362404; rs28362413; rs28362415; rs28362409; rs28362401; rs28362414; rs5829264; rs28362410; rs28362421; rs35725745; rs35284817; rs35628737; rs3134584; rs28362419; rs28362427; rs28362371; rs28362426; rs3095520; rs35759307; rs35221658; rs28362369; rs28362420; rs28362430; rs10929670; rs11694911; rs12465035; rs12692407; rs12692408; rs13000916; rs2357551; rs2430419; rs2430420; rs2463463; rs28498672; rs2884211; rs4233880; rs6432097; rs6731439; rs860169; rs885815

# Metabolic_Enzyme_5_General_References:
3595418; 2693021; 2587220; 2227439; 2318872; 1598217; 2317811; 3308908; 10623504

# Metabolic_Enzyme_5_References:
10657958; 14707; 3994674; 497223

# Metabolic_Enzyme_6_ID:
5449

# Metabolic_Enzyme_6_Name:
Spermine synthase

# Metabolic_Enzyme_6_Synonyms:
Spermidine aminopropyltransferase; SPMSY

# Metabolic_Enzyme_6_Gene_Name:
SMS

# Metabolic_Enzyme_6_Protein_Sequence:
>Spermine synthase
MAAARHSTLDFMLGAKADGETILKGLQSIFQEQGMAESVHTWQDHGYLATYTNKNGSFAN
LRIYPHGLVLLDLQSYDGDAQGKEEIDSILNKVEERMKELSQDSTGRVKRLPPIVRGGAI
DRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRA
IMGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDV
LDNLKGDCYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILD
LSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTV
WKKAKP

# Metabolic_Enzyme_6_Number_of_Residues:
366

# Metabolic_Enzyme_6_Molecular_Weight:
41269

# Metabolic_Enzyme_6_Theoretical_pI:
4.62

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
S-adenosylmethioninamine + spermidine = 5'- methylthioadenosine + spermine

# Metabolic_Enzyme_6_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00330  Arginine and proline metabolism;
 map00410  beta-Alanine metabolism

# Metabolic_Enzyme_6_Reaction:
S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF01564:Spermine_synth

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.5.1.22

# Metabolic_Enzyme_6_GenBank_ID_Protein:
791051

# Metabolic_Enzyme_6_SwissProt_ID:
SPSY_HUMAN (P52788)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
SMS

# Metabolic_Enzyme_6_Geneatlas_id:
SMS

# Metabolic_Enzyme_6_hgnc_id:
HGNC:11123

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>1107 bp
ATGCCTGGGGCAGCAGCACGGCACAGCACGCTCGACTTCATGCTCGGCGCCAAAGCTGAT
GGTGAGACCATTCTAAAAGGCCTCCAGTCCATTTTCCAGGAGCAGGGGATGGCGGAGTCG
GTGCACACCTGGCAGGACCATGGCTATTTAGCAACCTACACAAACAAGAACGGCAGCTTT
GCCAATTTGAGAATTTACCCACATGGATTGGTGTTGCTGGACCTTCAGAGTTATGATGGT
GATGCGCAAGGCAAAGAAGAGATCGACAGTATTTTGAACAAAGTAGAGGAAAGAATGAAA
GAATTGAGTCAGGACAGTACTGGGCGGGTGAAACGATTACCACCCATAGTGCGAGGAGGA
GCCATCGACAGATACTGGCCCACCGCCGACGGGCGCCTGGTTGAATATGACATAGATGAA
GTGGTATATGACGAAGATTCACCTTATCAAAATATAAAAATTCTACACTCGAAGCAGTTT
GGAAATATTCTCATCCTTAGTGGGGATGTTAATTTGGCAGAGAGTGATTTGGCATATACC
CGGGCCATCATGGGCAGTGGCAAAGAAGATTACACTGGCAAAGATGTACTCATTCTGGGA
GGTGGAGACGGAGGCATATTGTGTGAAATAGTCAAACTAAAACCAAAGATGGTCACTATG
GTAGAGATTGACCAAATGGTGATTGATGGGTGTAAGAAATACATGCGAAAAACGTGTGGC
GATGTCTTAGACAATCTTAAAGGAGACTGCTATCAGGTTCTAATAGAAGACTGTATCCCG
GTACTGAAGAGGTACGCCAAAGAAGGGAGAGAATTTGATTATGTGATTAATGATTTGACA
GCTGTTCCAATCTCCACGTCTCCAGAAGAAGATTCCACATGGGAGTTTCTCAGACTGATT
CTTGACCTCTCAATGAAAGTGTTGAAACAGGATGGGAAATATTTTACACAGGGGAACTGT
GTCAATCTGACAGAAGCACTGTCGCTCTATGAAGAACAGCTGGGGCGCCTGTATTGTCCT
GTGGAATTTTCAAAGGAGATCGTCTGTGTCCCTTCATACTTGGAATTGTGGGTATTTTAC
ACTGTTTGGAAGAAAGCTAAACCCTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
Z49099

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_6_Locus:
Xp22.1

# Metabolic_Enzyme_6_SNPs:
rs2238964; rs2283723; rs2238962; rs3747276; rs7891381; rs3891326; rs5951490; rs6528074; rs2238966; rs12013805; rs732946; rs5904497; rs2238958; rs5951678; rs4824217; rs2040357; rs4824171; rs732945; rs7051872; rs2238960; rs2238963; rs2238957; rs12688591; rs762702; rs5951672; rs7059727; rs5904598; rs6528077; rs1007321; rs1009643; rs16981696; rs2238961; rs2013191; rs5951676; rs7887293; rs5904600; rs7055676; rs6418750; rs768114; rs4824216; rs6633493; rs2238959; rs12012974; rs12558003; rs10521911; rs12862601; rs2239674; rs6629442; rs3747277; rs5904597; rs5904599; rs12690067; rs7883330; rs6629441; rs4824214; rs762703; rs2238967; rs12839771; rs6629443; rs5951491; rs6633490; rs4824213; rs11795630; rs6633492; rs6633500; rs2071136; rs6629444; rs6633491; rs6633496; rs2238965; rs7888401; rs5951670; rs7062138; rs5951487; rs16997426; rs7066893; rs1803034; rs4574966; rs4598383; rs4542061; rs4557827; rs3216777; rs4585875; rs34507903; rs3831664; rs41332250; rs9779369; rs7062457; rs28728153; rs7877597; rs36202602; rs6629445; rs5951677; rs41388452; rs12845823; rs3216386; rs1018768; rs11347193; rs6633497; rs11333369; rs10218267; rs12841614; rs3841770; rs4824215; rs35328914; rs5904596; rs3216385; rs10634009; rs12844253; rs12844382; rs5904498; rs6633502; rs7061670; rs12832046; rs7050034; rs35431500; rs12841626; rs12846025; rs11286374; rs12840980; rs34124534; rs5951674; rs12842132; rs12690070; rs6633494; rs34602887; rs6633495; rs34920205; rs11430711; rs35902649; rs6653656; rs12842231; rs7052122; rs35808743; rs6528076; rs5951671; rs43137; rs10702450; rs10606065; rs11373560; rs43138; rs34303071; rs12844555; rs28687310; rs12841708; rs5901691; rs11369551; rs36011591; rs5951675; rs34169359; rs12393765; rs12844043; rs10707194; rs35358672; rs35632927; rs35018744; rs35618002; rs10691989; rs13440719; rs7061351; rs43139; rs11447531; rs12844242; rs6633498; rs5951489; rs34048020; rs35831937; rs34834909; rs5901692; rs35888946; rs35705813; rs7888000; rs5951673; rs10604712; rs5951492; rs12844814; rs28403321; rs11797596; rs35504508; rs12389947; rs12832230; rs35398802; rs4394534; rs5904499; rs5904601; rs5951666; rs5951668; rs5951669; rs6528078; rs6654098; rs6654100; rs7066303

# Metabolic_Enzyme_6_General_References:
7546290; 9299240; 12665801

# Metabolic_Enzyme_6_References:
2917558; 6438490

End of HMDB00002

Beginning of HMDB00008
# Accession_No:
HMDB00008

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-17 12:08:47

# biospider_lastupdate:
2007-07-12 10:46:56

# Common_Name:
2-Hydroxybutyric acid

# Description:
An organic acid that is involved in propanoate metabolism.  It is found in urine of patients suffering from lactic acidosis and ketoacidosis.  2-Hydroxybutyric acid generally appears at high concentrations in situations related to deficient energy metabolism (e.g., birth asphyxia) and also in inherited metabolic diseases affecting the central nervous system during neonatal development, such as "cerebral" lactic acidosis, glutaric aciduria type II, dihydrolipoyl dehydrogenase (E3) deficiency, and propionic acidemia. It was concluded from studies done in the mid 1970's that an increased NADH2/NAD ratio was the most important factor for the production of 2-hydorxybutyric acid (PMID: 168632)

# Synonyms:
(RS)-2-Hydroxybutyrate; (RS)-2-Hydroxybutyric acid; 2-Hydroxy-n-butyrate; 2-Hydroxy-n-butyric acid; 2-Hydroxybutanoate; 2-Hydroxybutanoic acid; 2-Hydroxybutyrate; 2-hydroxy-Butanoate; 2-hydroxy-Butanoic acid; 2-hydroxy-DL-Butyrate; 2-hydroxy-DL-Butyric acid; DL-2-Hydroxybutanoate; DL-2-Hydroxybutanoic acid; DL-a-Hydroxybutyrate; DL-a-Hydroxybutyric acid; a-Hydroxy-n-butyrate; a-Hydroxy-n-butyric acid; a-Hydroxybutanoate; a-Hydroxybutanoic acid; a-Hydroxybutyrate; a-Hydroxybutyric acid; alpha-hydroxy-n-butyrate; alpha-hydroxy-n-butyric acid; DL-alpha-Hydroxybutyrate; DL-alpha-Hydroxybutyric acid; alpha-Hydroxybutanoate; alpha-Hydroxybutanoic acid; alpha-Hydroxybutyrate; alpha-Hydroxybutyric acid

# Chemical_IUPAC_Name:
2-hydroxybutanoic acid

# Chemical_Formula:
C4H8O3

# Chemical_Structure:
tbl_chemical:::HMDB00008_ZOOM.png:::119283123600066917

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00008_THUMB.png:::119283123417521278

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
secondary alcohol; carboxylic acid; alpha-hydroxyacid

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
104.04735

# Molecular_Weight_Avg:
104.10452

# Smiles_String_isomeric:
CCC(O)C(O)=O

# Smiles_String_canonical:
CCC(O)C(O)=O

# KEGG_Compound_ID:
C05984

# BioCyc_ID:
CPD-3564

# PubChem_CID:
11266

# PubChem_SID:
10347527; 154570; 7850103; 8158231; 671240; 72463; 6085418

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
47130

# Wikipedia_ID:
2-Hydroxybutyric acid

# METLIN_ID:
3783

# Ref_ID:
8257730; Aldrich Library of FT-IR Spectra, 1st edn., 1985, 1, 548D; Mori, K. et al., Tetrahedron, 1979, 35, 1601; Levene, P.A. et al., J. Biol. Chem., 1941, 141, 391; 168632; Duvillier, E., Ann. Chim. Phys., 1879, 17, 532; Chenault, H.K. et al., J.O.C., 1987, 52, 2608; Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 1, 854B; Horn, D.H.S. et al., J.C.S., 1954, 1460; Wong, C.H. et al., J.O.C., 1985, 50, 1992

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
600-15-7

# InChI:
InChI=1/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7)

# Synthesis_Reference:
Levene, P.A. et al., J. Biol. Chem., 1941, 141, 391; Timmermans, J. et al., Bull. Soc. Chim. Belg., 1951, 60, 424; Mori, K. et al., Tetrahedron, 1979, 35, 1601; Wong, C.H. et al., J.O.C., 1985, 50, 1992; Chenault, H.K. et al., J.O.C., 1987, 52, 2608

# Melting_Point:
44.2 oC

# Melting_Point_predicted:
25.6 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
1000.0 mg/mL [MEYLAN,WM et al. (1996)]; 484.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-0.16 [Predicted by ALOGPS]; -0.2 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00008_MSDS_1.html:::158193965507138

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00008.mol:::118425881896173852

# SDF_File_[Text]:
tbl_chemical:::HMDB00008.sdf:::119283123043518457

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00008.pdb:::119283123249554010

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:


# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041201_P01_04_BA_1DP_Presat.zip:::115651963672447263

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041201_P01_04_BA_1DP_Assinged.png:::117511839916177817

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041201_P01_04_BA_2DHSQC_1224.png:::116476205649793546

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041201_P01_04_BA_2DHSQC_1224.zip:::116476205650224933

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::2-hydroxybutyric acid (HMDB00008).png:::117330393645665723

# Predicted_H_NMR_Spectrum:
tbl_chemical:::2-Hydroxybutyric acid.gif:::1132732098171546504

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00008_peaks.txt:::1156309480012812045

# Predicted_C_NMR_Spectrum:
tbl_chemical:::2-Hydroxybutyric acid_C.gif:::1132737654994793414

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00008_peaks.txt:::1156310672113570981

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00008L.png:::117555263195855861; Medium Energy:tbl_ms:::HMDB00008M.png:::117555268487816902; High Energy:tbl_ms:::HMDB00008H.png:::117555271787217040

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; Extracellular

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	2.445 (0-4.89)	umol/mmol_creatinine	N/A	Both	Normal	168632
Blood	54.0 (8.0-80.0)	umol/L	Adult:>18_yrs_old	Both	Normal	8412012
Cerebrospinal_Fluid(CSF)	85.0	uM	Adult:>18_yrs_old	Both	Normal	HMP experimental
Cerebrospinal_Fluid(CSF)	37 +/- 21 (10 - 76)	uM	Children:1-13_yrs_old	Both	Normal	8376520
Cerebrospinal_Fluid(CSF)	35.0 +/- 24.0 	uM	Adult:>18_yrs_old	Both	Normal	8412012


# Concentration_[Abnormal]:
Urine	>25.0	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Pyruvate dehydrogenase deficiency	OMIM 238331


# Associated_Disorders:
Pyruvate dehydrogenase deficiency

# Pathway_Names:
Glycolysis;Pyruvate metabolism;Propanoate metabolism

# Pathway_Images:
Glycolysis.jpg;;

# KEGG_Images:
map00010;map00620;map00640

# Pathway_Graphs:
Glycolysis_Graph.jpg;;

# Pathway_SBMLs:
Glycolysis.xml;;

# Metabolic_Enzyme_1_ID:
5791

# Metabolic_Enzyme_1_Name:
L-lactate dehydrogenase B chain

# Metabolic_Enzyme_1_Synonyms:
LDH-B; LDH heart subunit; LDH-H; Renal carcinoma antigen NY-REN-46

# Metabolic_Enzyme_1_Gene_Name:
LDHB

# Metabolic_Enzyme_1_Protein_Sequence:
>Llactate dehydrogenase B chain
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLK
GEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKF
IIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLG
IHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAY
EVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARG
LTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL

# Metabolic_Enzyme_1_Number_of_Residues:
334

# Metabolic_Enzyme_1_Molecular_Weight:
36639

# Metabolic_Enzyme_1_Theoretical_pI:
5.93

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  anaerobic glycolysis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
(S)-lactate + NAD(+) = pyruvate + NADH

# Metabolic_Enzyme_1_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00272  Cysteine metabolism;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_1_Reaction:
(S)-lactate + NAD+ = pyruvate + NADH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF02866:Ldh_1_C;
PF00056:Ldh_1_N

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.1.1.27

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1200083

# Metabolic_Enzyme_1_SwissProt_ID:
LDHB_HUMAN (P07195)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
LDHB

# Metabolic_Enzyme_1_Geneatlas_id:
LDHB

# Metabolic_Enzyme_1_hgnc_id:
HGNC:6541

# Metabolic_Enzyme_1_PDB_ID:
1I0Z

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>129 bp
ATGGCAACTCTTAAGGAAAAACTCATTGCACCAGTTGCGGAAGAAGAGGCAACAGTTCCA
AACAATAAGATCACTGTAGTGGGTGTTGGACAAGTTGGTATGGCGTGTGCTATCAGCATT
CTGGGAAAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X13794

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_1_Locus:
12p12.2-p12.1

# Metabolic_Enzyme_1_SNPs:
rs3575; rs1650294; rs7297559; rs1677073; rs1629683; rs1677074; rs187457; rs7953579; rs1030452; rs1650318; rs1030453; rs11046147; rs1677075; rs11833048; rs4762716; rs1650315; rs4237915; rs1677076; rs1650317; rs1650307; rs1677111; rs1650300; rs1478293; rs1540405; rs1677108; rs1650301; rs1677110; rs1650305; rs7135799; rs1650289; rs759934; rs1650313; rs1650291; rs1677085; rs1677106; rs1650287; rs1650295; rs1677080; rs1677133; rs1650293; rs1614040; rs1677127; rs1624003; rs1677107; rs1650286; rs1650310; rs1677104; rs1677132; rs1616390; rs1650312; rs1650290; rs1677079; rs12319089; rs2114897; rs759932; rs1677129; rs1613896; rs1613889; rs1650306; rs1072993; rs1677124; rs759933; rs4275672; rs4337087; rs1650314; rs1677105; rs1677131; rs1677078; rs1072992; rs12312170; rs1677134; rs1677084; rs1677083; rs1677126; rs1650296; rs1650292; rs1650288; rs962947; rs1677128; rs1677125; rs2247376; rs1677139; rs1650283; rs1677140; rs153940; rs1677137; rs1650284; rs1677135; rs1677138; rs3759235; rs11547923; rs11547925; rs35460727; rs11547922; rs11547927; rs7966339; rs15140; rs11547926; rs11547929; rs11547931; rs11319412; rs15141; rs3203471; rs5796920; rs12368587; rs28369044; rs1650304; rs1650297; rs1677109; rs34268195; rs5796916; rs5796917; rs1478297; rs34667775; rs5796919; rs36050266; rs28424005; rs1616505; rs1650309; rs33984617; rs2126883; rs34439838; rs35336445; rs33930420; rs10716782; rs7298826; rs12307094; rs12308099; rs962946; rs10681437; rs34018310; rs1677113; rs34354944; rs5002144; rs35174029; rs11444668; rs10702414; rs34052790; rs34060682; rs28520103; rs2007049; rs35987638; rs1650311; rs34994333; rs28449925; rs35346295; rs5015840; rs35497937; rs28726969; rs1626023; rs5796918; rs35044122; rs11437489; rs35473871; rs28483251; rs35049167; rs5002142; rs34381931; rs10646800; rs34522871; rs12828206; rs5002143; rs34377909; rs11046146; rs1616506; rs7486051; rs1677081; rs35109393; rs5796915; rs1427830; rs33973125; rs4762862; rs11046144; rs35783676; rs1650285; rs1677136; rs10841865; rs10841867; rs10841868; rs10841869; rs10841872; rs11046153; rs11046154; rs11046159; rs11046160; rs12824788; rs12829701; rs12830306; rs1626167; rs1626303; rs1650277; rs1650278; rs1650279; rs1650280; rs1650282; rs1677090; rs1677091; rs1677092; rs1677093; rs1677094; rs1677096; rs1677098; rs1677100; rs1677141; rs16924082; rs17629491; rs4762714; rs4762856; rs4762857; rs4762858; rs4762859; rs4762863; rs7135965; rs7297042; rs7301852; rs7301883; rs7302639; rs7303528; rs7303612; rs7303644; rs7305475; rs7316427; rs7316475; rs7316669

# Metabolic_Enzyme_1_General_References:
2930497; 3435492; 10508479; 8314553; 8462975; 1587525; 2334429; 8611651; 10211631; 9929983; 11509017

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5792

# Metabolic_Enzyme_2_Name:
L-lactate dehydrogenase C chain

# Metabolic_Enzyme_2_Synonyms:
LDH-C; LDH testis subunit; LDH-X

# Metabolic_Enzyme_2_Gene_Name:
LDHC

# Metabolic_Enzyme_2_Protein_Sequence:
>Llactate dehydrogenase C chain
MSTVKEQLIEKLIEDDENSQCKITIVGTGAVGMACAISILLKDLADELALVDVALDKLKG
EMMDLQHGSLFFSTSKITSGKDYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSI
IPAIVHYSPDCKILVVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGV
HPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLGTDSDKEHWKNIHKQVIQSAYE
IIKLKGYTSWAIGLSVMDLVGSILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGV
SDVVKINLNSEEEALFKKSAETLWNIQKDLIF

# Metabolic_Enzyme_2_Number_of_Residues:
332

# Metabolic_Enzyme_2_Molecular_Weight:
36312

# Metabolic_Enzyme_2_Theoretical_pI:
7.53

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  anaerobic glycolysis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
Possible role in sperm motility

# Metabolic_Enzyme_2_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00272  Cysteine metabolism;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_2_Reaction:
(S)-lactate + NAD+ = pyruvate + NADH + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF02866:Ldh_1_C;
PF00056:Ldh_1_N

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.1.27

# Metabolic_Enzyme_2_GenBank_ID_Protein:
307120

# Metabolic_Enzyme_2_SwissProt_ID:
LDHC_HUMAN (P07864)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
LDHC

# Metabolic_Enzyme_2_Geneatlas_id:
LDHC

# Metabolic_Enzyme_2_hgnc_id:
HGNC:6544

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>999 bp
ATGTCAACTGTCAAGGAGCAGCTAATTGAGAAGCTAATTGAGGATGATGAAAACTCCCAG
TGTAAAATTACTATTGTTGGAACTGGTGCCGTAGGCATGGCTTGTGCTATTAGTATCTTA
CTGAAGGATTTGGCTGATGAACTTGCCCTTGTTGATGTTGCATTGGACAAACTGAAGGGA
GAAATGATGGATCTTCAGCATGGCAGTCTTTTCTTTAGTACTTCAAAGGTTACTTCTGGA
AAAGATTACAGTGTATCTGCAAACTCCAGAATAGTTATTGTCACAGCAGGTGCAAGGCAG
CAGGAGGGAGAAACTCGCCTTGCCCTGGTCCAACGTAATGTGGCTATAATGAAAATAATC
ATTCCTGCCATAGTCCATTATAGTCCTGATTGTAAAATTCTTGTTGTTTCAAATCCAGTG
GATATTTTGACATATATAGTCTGGAAGATAAGTGGCTTACCTGTAACTCGTGTAATTGGA
AGTGGTTGTAATCTAGACTCTGCCCGTTTCCGTTACCTAATTGGAGAAAAGTTGGGTGTC
CACCCCACAAGCTGCCATGGTTGGATTATTGGAGAACATGGTGATTCTAGTGTGCCCTTA
TGGAGTGGGGTGAATGTTGCTGGTGTTGCTCTGAAGACTCTGGACCCTAAATTAGGAACG
GATTCAGATAAGGAACACTGGAAAAATATCCATAAACAAGTTATTCAAAGTGCCTATGAA
ATTATCAAGCTGAAGGGGTATACCTCTTGGGCTATTGGACTGTCTGTGATGGATCTGGTA
GGATCCATTTTGAAAAATCTTAGGAGAGTGCACCCAGTTTCCACCATGGTTAAGGGATTA
TATGGAATAAAAGAAGAACTCTTTCTCAGTATCCCTTGTGTCTTGGGGCGGAATGGTGTC
TCAGATGTTGTGAAAATTAACTTGAATTCTGAGGAGGAGGCCCTTTTCAAGAAGAGTGCA
GAAACACTTTGGAATATTCAAAAGGATCTAATATTTTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
J02938

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_2_Locus:
11p15.5-p15.3

# Metabolic_Enzyme_2_SNPs:
rs16935436; rs1881717; rs12293002; rs2037868; rs1908560; rs2056781; rs2896527; rs2403280; rs1406580; rs2658566; rs7111815; rs2643856; rs2721126; rs2658551; rs11024647; rs3740713; rs12270402; rs10832934; rs7938942; rs12289603; rs2658548; rs4757662; rs10766478; rs16935432; rs16935431; rs16935424; rs2403298; rs2698563; rs12416742; rs11606494; rs2056783; rs2698566; rs7110605; rs10766477; rs11024648; rs2698558; rs6486427; rs35593189; rs2056782; rs4757664; rs2643857; rs2698568; rs2658549; rs11024651; rs12282669; rs11024649; rs968895; rs1848049; rs2658553; rs12576249; rs4757663; rs11605386; rs3809096; rs3809098; rs4757660; rs7938267; rs3809097; rs7951953; rs4757656; rs1506520; rs4757655; rs11558332; rs11558333; rs2658565; rs3740714; rs10610261; rs12807225; rs11292121; rs2463909; rs35077834; rs4756943; rs11024652; rs11024657; rs35754271; rs35064545; rs11325380; rs34480310; rs33998563; rs2056784; rs2643871; rs34279411; rs36113234; rs1318593; rs7481716; rs2643855; rs2721120; rs11024653; rs35128109; rs4628652; rs12806009; rs11313322; rs184855; rs4990347; rs1908561; rs2643859; rs34485747; rs36038254; rs35126672; rs35017114; rs35689913; rs34109624; rs35720604; rs35770509; rs34907251; rs34630228; rs35915766; rs12803458; rs34176196; rs5790036; rs4990348; rs11024650; rs1506519; rs2698562; rs34844393; rs34305958; rs3074202; rs11024655; rs34903699; rs4990349; rs12801224; rs7112151; rs2698569; rs2698557; rs35478086; rs4990345; rs1908562; rs11308924; rs2658550; rs35313043; rs12795955; rs35861956; rs35617285; rs36043375; rs2721125; rs34960411; rs1848048; rs34287236; rs35857834; rs33993685; rs34546967; rs11024656; rs2254195; rs5790037; rs36045982; rs34500057; rs4990346; rs171495; rs11321502; rs34884188; rs35134819; rs2698561; rs35976847; rs187227; rs34511927; rs35749455; rs2721124; rs35284710; rs2643860; rs28729286; rs2643872; rs35299578; rs34684673; rs35515498; rs12799374; rs35192552; rs7115524; rs189660; rs2643858; rs7111938; rs34515949; rs4757659; rs4757661; rs4757658; rs4757657; rs10832932; rs11024643; rs11024645; rs11605559; rs12269752; rs16935411; rs16935413; rs1881716; rs2721121; rs34305721; rs34546419; rs35864573; rs3758680; rs3758681; rs3758682; rs3758683; rs3781641; rs4757653; rs6486425

# Metabolic_Enzyme_2_General_References:
2440048; 2930531

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5793

# Metabolic_Enzyme_3_Name:
L-lactate dehydrogenase A chain

# Metabolic_Enzyme_3_Synonyms:
LDH-A; LDH muscle subunit; LDH-M; Proliferation-inducing gene 19 protein; Renal carcinoma antigen NY-REN-59

# Metabolic_Enzyme_3_Gene_Name:
LDHA

# Metabolic_Enzyme_3_Protein_Sequence:
>Llactate dehydrogenase A chain
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF

# Metabolic_Enzyme_3_Number_of_Residues:
332

# Metabolic_Enzyme_3_Molecular_Weight:
36689

# Metabolic_Enzyme_3_Theoretical_pI:
8.45

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  anaerobic glycolysis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
(S)-lactate + NAD(+) = pyruvate + NADH

# Metabolic_Enzyme_3_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00272  Cysteine metabolism;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_3_Reaction:
(S)-lactate + NAD+ = pyruvate + NADH + H+

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF02866:Ldh_1_C;
PF00056:Ldh_1_N

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.1.1.27

# Metabolic_Enzyme_3_GenBank_ID_Protein:
34313

# Metabolic_Enzyme_3_SwissProt_ID:
LDHA_HUMAN (P00338)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
LDHA

# Metabolic_Enzyme_3_Geneatlas_id:
LDHA

# Metabolic_Enzyme_3_hgnc_id:
HGNC:6535

# Metabolic_Enzyme_3_PDB_ID:
1I10

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>999 bp
ATGGCAACTCTAAAGGATCAGCTGATTTATAATCTTCTAAAGGAAGAACAGACCCCCCAG
AATAAGATTACAGTTGTTGGGGTTGGTGCTGTTGGCATGGCCTGTGCCATCAGTATCTTA
ATGAAGGACTTGGCAGATGAACTTGCTCTTGTTGATGTCATCGAAGACAAATTGAAGGGA
GAGATGATGGATCTCCAACATGGCAGCCTTTTCCTTAGAACACCAAAGATTGTCTCTGGC
AAAGACTATAATGTAACTGCAAACTCCAAGCTGGTCATTATCACGGCTGGGGCACGTCAG
CAAGAGGGAGAAAGCCGTCTTAATTTGGTCCAGCGTAACGTGAACATATTTAAATTCATC
ATTCCTAATGTTGTAAAATACAGCCCGAACTGCAAGTTGCTTATTGTTTCAAATCCAGTG
GATATCTTGACCTACGTGGCTTGGAAGATAAGTGGTTTTCCCAAAAACCGTGTTATTGGA
AGTGGTTGCAATCTGGATTCAGCCCGATTCCGTTACCTGATGGGGGAAAGGCTGGGAGTT
CACCCATTAAGCTGTCATGGGTGGGTCCTTGGGGAACATGGAGATTCCAGTGTGCCTGTA
TGGAGTGGAATGAATGTTGCTGGTGTCTCTCTGAAGACTCTGCACCCAGATTTAGGGACT
GATAAAGATAAGGAACAGTGGAAAGAGGTTCACAAGCAGGTGGTTGAGAGTGCTTATGAG
GTGATCAAACTCAAAGGCTACACATCCTGGGCTATTGGACTCTCTGTAGCAGATTTGGCA
GAGAGTATAATGAAGAATCTTAGGCGGGTGCACCCAGTTTCCACCATGATTAAGGGTCTT
TACGGAATAAAGGATGATGTCTTCCTTAGTGTTCCTTGCATTTTGGGACAGAATGGAATC
TCAGACCTTGTGAAGGTGACTCTGACTTCTGAGGAAGAGGCCCGTTTGAAGAAGAGTGCA
GATACACTTTGGGGGATCCAAAAGGAGCTGCAATTTTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X02152

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_3_Locus:
11p15.4

# Metabolic_Enzyme_3_SNPs:
rs5030621; rs4820; rs6498; rs7932887; rs7111748; rs2403279; rs1969565; rs2249631; rs1830425; rs1881716; rs1830426; rs4757652; rs6486425; rs3781641; rs10832932; rs2896526; rs4274186; rs7121244; rs12284013; rs12274651; rs10766475; rs3758680; rs10832928; rs10832931; rs16935411; rs10766476; rs1969563; rs11601413; rs7117399; rs12576300; rs10832929; rs10832933; rs1969564; rs16935413; rs7120485; rs7130990; rs7947664; rs1969562; rs11024644; rs6486424; rs7101840; rs10832930; rs7128549; rs7129689; rs3758682; rs2403278; rs3758683; rs3758681; rs4757650; rs6486423; rs11553874; rs34305721; rs11553873; rs11553866; rs11553870; rs12790695; rs11553865; rs7107861; rs12278153; rs4757651; rs11553862; rs35609290; rs34692667; rs12293161; rs14790; rs14789; rs35726777; rs35873857; rs35510986; rs11024642; rs35960334; rs35254161; rs12788225; rs11024645; rs12221941; rs34970587; rs10562494; rs12221918; rs12221905; rs11024643; rs33912958; rs5790035; rs11601409; rs35073059; rs11024641; rs6144242; rs34302007; rs10554414; rs10684351; rs12789257; rs6144241; rs35006409; rs35938126; rs34740438; rs35797685; rs11403792; rs35341031; rs11383902; rs35007005; rs10832927; rs10832934; rs11024640; rs11024647; rs11024649; rs11605386; rs12269752; rs12578098; rs2037868; rs3740714; rs3809096; rs3809097; rs3809098; rs4757653; rs4757661; rs7106099

# Metabolic_Enzyme_3_General_References:
3838278; 3000353; 1959923; 10508479; 1445373; 7908613

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5794

# Metabolic_Enzyme_4_Name:
L-lactate dehydrogenase A-like 6B

# Metabolic_Enzyme_4_Synonyms:
Not Available

# Metabolic_Enzyme_4_Gene_Name:
LDHAL6B

# Metabolic_Enzyme_4_Protein_Sequence:
>Llactate dehydrogenase Alike 6
BMSWTVPVVRASQRVSSVGANFLCLGMALCPRQATRIPLNGTWLFTPVSKMATVKSELIE
RFTSEKPVHHSKVSIIGTGSVGMACAISILLKGLSDELALVDLDEDKLKGETMDLQHGSP
FTKMPNIVCSKDYFVTANSNLVIITAGARQEKGETRLNLVQRNVAIFKLMISSIVQYSPH
CKLIIVSNPVDILTYVAWKLSAFPKNRIIGSGCNLDTARFRFLIGQKLGIHSESCHGWIL
GEHGDSSVPVWSGVNIAGVPLKDLNSDIGTDKDPEQWKNVHKEVTATAYEIIKMKGYTSW
AIGLSVADLTESILKNLRRIHPVSTIIKGLYGIDEEVFLSIPCILGENGITNLIKIKLTP
EEEAHLKKSAKTLWEIQNKLKL

# Metabolic_Enzyme_4_Number_of_Residues:
381

# Metabolic_Enzyme_4_Molecular_Weight:
41943

# Metabolic_Enzyme_4_Theoretical_pI:
8.89

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  anaerobic glycolysis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
(S)-lactate + NAD(+) = pyruvate + NADH

# Metabolic_Enzyme_4_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00272  Cysteine metabolism;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_4_Reaction:
(S)-lactate + NAD+ = pyruvate + NADH + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF02866:Ldh_1_C;
PF00056:Ldh_1_N

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.1.1.27

# Metabolic_Enzyme_4_GenBank_ID_Protein:
12331000

# Metabolic_Enzyme_4_SwissProt_ID:
LDH6B_HUMAN (Q9BYZ2)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
LDHAL6B

# Metabolic_Enzyme_4_Geneatlas_id:
LDHAL6B

# Metabolic_Enzyme_4_hgnc_id:
HGNC:21481

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>1146 bp
ATGAGTTGGACTGTGCCTGTTGTGCGGGCCAGCCAGAGAGTGAGCTCGGTGGGAGCGAAT
TTCCTATGCCTGGGGATGGCCCTGTGTCCGCGTCAAGCAACGCGCATCCCGCTCAACGGC
ACCTGGCTCTTCACCCCCGTGAGCAAGATGGCGACTGTGAAGAGTGAGCTTATTGAGCGT
TTCACTTCCGAGAAGCCCGTTCATCACAGTAAGGTCTCCATCATAGGAACTGGATCGGTG
GGCATGGCCTGCGCTATCAGCATCTTATTAAAAGGCTTGAGTGATGAACTTGCCCTTGTG
GATCTTGATGAAGACAAACTGAAGGGTGAGACGATGGATCTTCAACATGGCAGCCCTTTC
ACGAAAATGCCAAATATTGTTTGTAGCAAAGATTACTTTGTCACAGCAAACTCCAACCTA
GTGATTATCACAGCAGGTGCACGCCAAGAAAAGGGAGAAACGCGCCTTAATTTAGTCCAG
CGAAATGTGGCCATCTTCAAGTTAATGATTTCCAGTATTGTCCAGTACAGCCCCCACTGC
AAACTGATTATTGTTTCCAATCCAGTGGATATCTTAACTTATGTAGCTTGGAAGTTGAGT
GCATTTCCCAAAAACCGTATTATTGGAAGCGGCTGTAATCTGGATACTGCTCGTTTTCGT
TTCTTGATTGGACAAAAGCTTGGTATCCATTCTGAAAGCTGCCATGGATGGATCCTCGGA
GAGCATGGAGACTCAAGTGTTCCTGTGTGGAGTGGAGTGAACATAGCTGGTGTCCCTTTG
AAGGATCTGAACTCTGATATAGGAACTGATAAAGATCCTGAGCAATGGAAAAATGTCCAC
AAAGAAGTGACTGCAACTGCCTATGAGATTATTAAAATGAAAGGTTATACTTCTTGGGCC
ATTGGCCTATCTGTGGCCGATTTAACAGAAAGTATTTTGAAGAATCTTAGGAGAATACAT
CCAGTTTCCACCATAATTAAGGGCCTCTATGGAATAGATGAAGAAGTATTCCTCAGTATT
CCTTGTATCCTGGGAGAGAACGGTATTACCAACCTTATAAAGATAAAGCTGACCCCTGAA
GAAGAGGCCCATCTGAAAAAAAGTGCAAAAACACTCTGGGAAATTCAGAATAAGCTTAAG
CTTTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AY009108

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_4_Locus:
15q22.2

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
Not Available

# Metabolic_Enzyme_4_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8617

# Macromolecular_Interacting_Partner_1_Name:
UEVLD protein

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
UEVLD

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>UEVLD protein
MEFDCEGLRRLLGKYKFRDLTVEELRNVNVFFPHFKYSMDTYGNTYNIPIRFWILDSHPF
APPICFLKPTANMGILVGKHVDAQGRIYLPYLQNWSHPKSVIVGLIKEMIAKFQEELPMY
SLSSSDEARQVDLLAYIAKITEGVSDTNSKSWANHENKTVNKITVVGGGELGIACTLAIS
AKGIADRLVLLDLSEGTKGATMDLEIFNLPNVEISKDLSASAHSKVVIFTVNSLGSSQSY
LDVVQSNVDMFRALVPALGHYSQHSVLLVASQPVEIMTYVTWKLSTFPANRVIGIGCNLD
SQRLQYIITNVLKAQTSGKEVWVIGEQGEDKVLTWSGQEEVVSHTSQVQLSNRDIMI

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
357

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
39778

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.42

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
 Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
 Process:  cellular physiological process
Process:  transport
Process:  protein transport
Process:  ubiquitin cycle
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_1_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00056:Ldh_1_N
PF05743:UEV

# Macromolecular_Interacting_Partner_1_Signals:
Not Available

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
40555769

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
Q6P2F0_HUMAN (Q6P2F0)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
UEVLD

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
UEVLD

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:30866

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1074 bp
ATGGAGTTCGACTGCGAGGGCCTGAGACGGCTGCTTGGCAAGTACAAGTTCAGGGACCTA
ACTGTGGAAGAACTAAGGAATGTAAATGTATTTTTCCCACATTTCAAATATTCCATGGAC
ACCTATGGTAATACATATAACATACCAATTCGTTTCTGGATTTTGGATTCTCACCCTTTC
GCTCCCCCTATTTGCTTCTTGAAGCCAACTGCAAATATGGGAATCTTAGTCGGAAAACAT
GTGGATGCTCAAGGCAGAATATATTTGCCCTATCTCCAAAACTGGAGCCATCCTAAATCT
GTCATTGTTGGATTAATTAAAGAAATGATTGCCAAGTTTCAAGAGGAACTTCCCATGTAT
TCTCTATCATCATCTGATGAGGCACGGCAGGTAGACTTGCTAGCCTATATTGCAAAAATC
ACTGAAGGTGTTTCAGATACAAATTCAAAGAGCTGGGCAAATCATGAGAATAAAACAGTC
AATAAAATTACTGTGGTTGGAGGTGGAGAACTCGGTATTGCCTGCACATTAGCAATTTCA
GCAAAGGGTATTGCAGACAGGCTTGTCCTCTTAGACCTCTCAGAAGGGACTAAAGGAGCC
ACGATGGACCTTGAAATCTTCAACCTTCCTAATGTGGAGATCAGCAAAGATTTGTCTGCC
TCTGCTCATTCCAAGGTGGTGATCTTCACAGTCAACTCTTTGGGTAGTTCTCAGTCGTAC
CTTGATGTGGTACAGAGCAATGTGGATATGTTCAGAGCCCTTGTCCCAGCTCTGGGACAT
TATAGTCAACACAGTGTCCTGCTCGTTGCATCTCAACCAGTGGAAATCATGACCTATGTA
ACATGGAAACTGAGTACATTTCCTGCAAATCGAGTGATCGGAATTGGATGTAATCTGGAT
TCACAGAGATTACAGTATATTATTACAAATGTTTTGAAGGCACAGACTTCAGGCAAAGAA
GTATGGGTTATTGGCGAGCAAGGAGAAGACAAAGTGCTCACATGGAGTGGCCAAGAAGAA
GTAGTGAGTCATACCTCTCAAGTGCAGCTGTCCAACAGGGATATTATGATATAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
BC064566

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11p15.1

# Macromolecular_Interacting_Partner_1_SNPs:
rs10500835; rs34242612; rs4756952; rs7950602; rs7107057; rs4756951; rs6486434; rs10832940; rs7105889; rs7109314; rs2305166; rs10741747; rs11024718; rs11024717; rs11024715; rs7928508; rs10766485; rs4756949; rs4756950; rs16935539; rs11024716; rs2271080; rs7942733; rs10741745; rs2271079; rs12577416; rs12420702; rs16935575; rs12577346; rs6486435; rs7119085; rs11024706; rs10832943; rs2305167; rs11822477; rs12577619; rs11024711; rs7951508; rs16935543; rs12418907; rs11024709; rs1857907; rs10219146; rs7952284; rs11024725; rs10832942; rs4757672; rs7130163; rs12224694; rs7101733; rs16935538; rs11024719; rs7108487; rs7483340; rs11024722; rs7109496; rs10832946; rs17392588; rs12420882; rs12225461; rs4756948; rs7102116; rs11825249; rs10219166; rs7940645; rs12421803; rs10741746; rs16935559; rs11024723; rs12419223; rs12225037; rs10832947; rs10832944; rs16935541; rs12803251; rs12418726; rs10766486; rs11024724; rs7107204; rs16935557; rs12049912; rs12289644; rs10832941; rs7116316; rs3781639; rs10832945; rs4623881; rs7106180; rs12289223; rs7926511; rs13377281; rs33991194; rs193330; rs11445836; rs968711; rs12794725; rs35449210; rs10638102; rs11024713; rs34853816; rs12049909; rs11024703; rs34081721; rs34109550; rs35749759; rs12796224; rs33928228; rs3214765; rs4756947; rs34523639; rs7948475; rs12796202; rs28607050; rs4417245; rs12790354; rs11600760; rs10683299; rs12795883; rs35059773; rs12049851; rs7119501; rs35960383; rs7934311; rs968712; rs11024705; rs34474192; rs34736014; rs12790143; rs11024726; rs35798683; rs11024712; rs34170647; rs12807106; rs34286769; rs34951254; rs35410505; rs12792924; rs35715013; rs12280959; rs35038497; rs12225251; rs11449292; rs36022682; rs11024704; rs35032055; rs12278992; rs35875343; rs5790040; rs12795875; rs35900814; rs12223260; rs11024721; rs35864596; rs12226584; rs11024714; rs34120372; rs11600244; rs34327848; rs36054394; rs35906676; rs35944144; rs34900962; rs4757671; rs34888550; rs35110669; rs11394988; rs3837379; rs7116220; rs34434085; rs34297128; rs10540605; rs35315027; rs3832729; rs34999373; rs11024720; rs35047705; rs35274706; rs34545423; rs11602888; rs34585786; rs11603372; rs12574808; rs35702732; rs12421881; rs11302053; rs34139368; rs35384688; rs12804077; rs12290527; rs34587461; rs34646785; rs11443134; rs34386323; rs11602699; rs34857682; rs34561317; rs11024710; rs12222154; rs35537932; rs10734260; rs4757670; rs34226030; rs10444226; rs11024701; rs12287275; rs12785294; rs1395319; rs1395320; rs1530565; rs1547497; rs1857908; rs1857909; rs1979051; rs1983124; rs2088184; rs2121386; rs2174614; rs2292177; rs2292178; rs2292179; rs3802965; rs3802966; rs4436523; rs4757673; rs6416020; rs7931630

# Macromolecular_Interacting_Partner_1_General_References:
12477932

# Macromolecular_Interacting_Partner_1_References:
Not Available

End of HMDB00008

Beginning of HMDB00010
# Accession_No:
HMDB00010

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-01-09 14:07:54

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
2-Methoxyestrone

# Description:
A steroid derivative that is a byproduct of estrone and 2-hydroxyestrone metabolism.  It is part of the androgen and estrogen metabolic pathway.

# Synonyms:
2-(8S,9S,13S,14S)-3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one; 2-Hydroxyestrone 2-methyl ether; 2-Methoxy-17-oxoestra-1,3,5(10)-trien-3-ol; 2-Methoxy-3-hydroxyestra-1,3,5(10)-trien-17-one; 3-Hydroxy-2-methoxyestra-1,3,5(10)-trien-17-one; 3-hydroxy-2-methoxy-Estra-1,3,5(10)-trien-17-one; methoxy-Estrone

# Chemical_IUPAC_Name:
3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one

# Chemical_Formula:
C19H24O3

# Chemical_Structure:
tbl_chemical:::HMDB00010_ZOOM.png:::119283124960011285

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00010_THUMB.png:::119283124753353551

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Steroids; Sterols

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
ketone; phenol or hydroxyhetarene; alkyl aryl ether; aromatic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
300.17255

# Molecular_Weight_Avg:
300.39209

# Smiles_String_isomeric:
COC1=CC2=C(CC[C@H]3[C@@H]4CCC(=O)[C@@]4(C)CC[C@H]23)C=C1O

# Smiles_String_canonical:
COC1=CC2=C(CCC3C4CCC(=O)C4(C)CCC23)C=C1O

# KEGG_Compound_ID:
C05299

# BioCyc_ID:
ESTRONE-SULFATE

# PubChem_CID:
440624

# PubChem_SID:
7683; 10298626; 841376

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Not Available

# METLIN_ID:
2578

# Ref_ID:
9812172; Kraychy, S., J.A.C.S., 1957, 79, 754 and 1959, 81, 1702, (ethers); Miyazaki, M. et al., J.O.C., 1968, 33, 662, (sulfate); Shimada, K. et al., J. Chromatogr., 1979, 178, 350, (HPLC); 6863476; 462497; Gelbke, H.P. et al., Steroids, 1973, 21, 205, (synthesis, PMR); Douglas, G.H. et al., J. Med. Chem., 1966, 9, 27, (synthesis, UV, (+/-)-form)

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
362-08-3

# InChI:
InChI=1/C19H24O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,20H,3-8H2,1-2H3/t12-,13+,15-,19-/m0/s1

# Synthesis_Reference:
Fishman, J. et al., J.O.C., 1960, 25, 585; Rao, P.N. et al., J.C.S., 1961, 4769; Douglas, G.H. et al., J. Med. Chem., 1966, 9, 27; Gelbke, H.P. et al., Steroids, 1973, 21, 205; Kirk, D.N. et al., J. Chem. Res., Synop., 1983, 228

# Melting_Point:
187.0-189.5 oC

# Melting_Point_predicted:
126.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
7.49e-03 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
3.50 [Predicted by ALOGPS]; 3.5 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::2-Methoxyestrone.pdf:::113256218900391369

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::2-Methoxyestrone.mol:::1132723680593329421

# SDF_File_[Text]:
tbl_chemical:::HMDB00010.sdf:::119283124031340517

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00010.pdb:::119283124579548268

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::2-Methoxyestrone.gif:::1132732098375641852

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00010_peaks.txt:::115630948102412348

# Predicted_C_NMR_Spectrum:
tbl_chemical:::2-Methoxyestrone_C.gif:::1132737655785195462

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00010_peaks.txt:::115631067313567449

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Urine

# Concentration_[Normal]:
Urine	0.005 (0.004-0.006)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9812172


# Concentration_[Abnormal]:
Urine	0.025 (0.02-0.03)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Prolactinoma	9812172


# Associated_Disorders:
Prolactinoma; Prostate Cancer

# Pathway_Names:
Pentose and glucuronate interconversions;Androgen and estrogen metabolism;Starch and sucrose metabolism;Porphyrin and chlorophyll metabolism

# Pathway_Images:
;;;

# KEGG_Images:
map00040;map00150;map00500;map00860

# Pathway_Graphs:
;;;

# Pathway_SBMLs:
;;;

# Metabolic_Enzyme_1_ID:
5732

# Metabolic_Enzyme_1_Name:
UDP-glucuronosyltransferase 1-6 precursor

# Metabolic_Enzyme_1_Synonyms:
UDP- glucuronosyltransferase 1A6; UDPGT; UGT1*6; UGT1-06; UGT1.6; UGT- 1F; UGT1F; Phenol-metabolizing UDP-glucuronosyltransferase

# Metabolic_Enzyme_1_Gene_Name:
UGT1A6

# Metabolic_Enzyme_1_Protein_Sequence:
>UDPglucuronosyltransferase 16 precursor
MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVV
PEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIG
LYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEH
TFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRD
VDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHG
IVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLL
GHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSE
DLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDL
TWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_1_Number_of_Residues:
532

# Metabolic_Enzyme_1_Molecular_Weight:
60751

# Metabolic_Enzyme_1_Theoretical_pI:
8.55

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols

# Metabolic_Enzyme_1_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_1_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_1_Signals:
1-26

# Metabolic_Enzyme_1_Transmembrane_Regions:
490-506

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_1_GenBank_ID_Protein:
340141

# Metabolic_Enzyme_1_SwissProt_ID:
UD16_HUMAN (P19224)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
UGT1A6

# Metabolic_Enzyme_1_Geneatlas_id:
UGT1A6

# Metabolic_Enzyme_1_hgnc_id:
HGNC:12538

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Microsome

# Metabolic_Enzyme_1_Gene_Sequence:
>861 bp
ATGGCCTGCCTCCTTCGCTCATTTCAGAGAATTTCTGCAGGGGTTTTCTTCTTAGCACTT
TGGGGCATGGTTGTAGGTGACAAGCTGCTGGTGGTCCCTCAGGACGGAAGCCACTGGCTT
AGTATGAAGGATATAGTTGAGGTTCTCAGTGACCGGGGTCATGAGATTGTAGTGGTGGTG
CCTGAAGTTAATTTGCTTTTGAAAGAATCCAAATACTACACAAGAAAAATCTATCCAGTG
CCGTATGACCAAGAAGAGCTGAAGAACCGTTACCAATCATTTGGAAACAATCACTTTGCT
GAGCGATCATTCCTAACTGCTCCTCAGACAGAGTACAGGAATAACATGATTGTTATTGGC
CTGTACTTCATCAACTGCCAGAGCCTCCTGCAGGACAGGGACACCCTGAACTTCTTTAAG
GAGAGCAAGTTTGATGCTCTTTTCACAGACCCAGCCTTACCCTGTGGGGTGATCCTGGCT
GAGTATTTGGGCCTACCATCTGTGTACCTCTTCAGGGGTTTTCCGTGTTCCCTGGAGCAT
ACATTCAGCAGAAGCCCAGACCCTGTGTCCTACATTCCCAGGTGCTACACAAAGTTTTCA
GACCACATGACTTTTTCCCAACGAGTGGCCAACTTCCTTGTTAATTTGTTGGAGCCCTAT
CTATTTTATTGTCTGTTTTCAAAGTATGAAGAACTCGCATCAGCTGTCCTCAAGAGAGAT
GTGGATATAATCACCTTATATCAGAAGGTCTCTGTTTGGCTGTTAAGATATGACTTTGTG
CTTGAATATCCTAGGCCGGTCATGCCCAACATGGTCTTCATTGGAGGTATCAACTGTAAG
AAGAGGAAAGACTTGTCTCAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M84130

# Metabolic_Enzyme_1_Chromosome_Location:
Not Available

# Metabolic_Enzyme_1_Locus:
Not Available

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
1339448; 3141926; 11434514; 9466822; 9429234

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5796

# Metabolic_Enzyme_2_Name:
Catechol-O-methyltransferase

# Metabolic_Enzyme_2_Synonyms:
Not Available

# Metabolic_Enzyme_2_Gene_Name:
Not Available

# Metabolic_Enzyme_2_Protein_Sequence:
>CatecholOmethyltransferase
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRIL
NHVLQHAEPGNAQSVLEAIDTYCE

# Metabolic_Enzyme_2_Number_of_Residues:
84

# Metabolic_Enzyme_2_Molecular_Weight:
9399

# Metabolic_Enzyme_2_Theoretical_pI:
4.88

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  O-methyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Not Available

# Metabolic_Enzyme_2_Pathway:
Not Available

# Metabolic_Enzyme_2_Reaction:
Not Available

# Metabolic_Enzyme_2_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_2_Signals:
1-32

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.1.1.6

# Metabolic_Enzyme_2_GenBank_ID_Protein:
30583089

# Metabolic_Enzyme_2_SwissProt_ID:
Q7KZP0_HUMAN (Q7KZP0)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
Not Available

# Metabolic_Enzyme_2_Geneatlas_id:
Not Available

# Metabolic_Enzyme_2_hgnc_id:
HGNC:2228

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Membrane

# Metabolic_Enzyme_2_Gene_Sequence:
>255 bp
ATGCCGGAGGCCCCGCCTCTGCTGTTGGCAGCTGTGTTGCTGGGCCTGGTGCTGCTGGTG
GTGCTGCTGCTGCTTCTGAGGCACTGGGGCTGGGGCCTGTGCCTTATCGGCTGGAACGAG
TTCATCCTGCAGCCCATCCACAACCTGCTCATGGGTGACACCAAGGAGCAGCGCATCCTG
AACCATGTGCTGCAGCATGCGGAGCCCGGGAACGCACAGAGCGTGCTGGAGGCCATTGAC
ACCTACTGCGAGTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
BT007125

# Metabolic_Enzyme_2_Chromosome_Location:
Not Available

# Metabolic_Enzyme_2_Locus:
Not Available

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
Not Available

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5721

# Metabolic_Enzyme_3_Name:
UDP-glucuronosyltransferase 2B7 precursor

# Metabolic_Enzyme_3_Synonyms:
UDPGT; 3,4- catechol estrogen specific; UDPGTh-2

# Metabolic_Enzyme_3_Gene_Name:
UGT2B7

# Metabolic_Enzyme_3_Protein_Sequence:
>UDPglucuronosyltransferase 2B7 precursor
MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSA
SILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFG
DITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTF
EKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVL
GRPTTLSETMGKADVWLIRNSWNFQFPHPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSG
ENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTM
SSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND

# Metabolic_Enzyme_3_Number_of_Residues:
529

# Metabolic_Enzyme_3_Molecular_Weight:
60695

# Metabolic_Enzyme_3_Theoretical_pI:
8.45

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites

# Metabolic_Enzyme_3_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_3_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_3_Signals:
1-23

# Metabolic_Enzyme_3_Transmembrane_Regions:
493-509

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_3_GenBank_ID_Protein:
340080

# Metabolic_Enzyme_3_SwissProt_ID:
UDB7_HUMAN (P16662)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
UGT2B7

# Metabolic_Enzyme_3_Geneatlas_id:
UGT2B7

# Metabolic_Enzyme_3_hgnc_id:
HGNC:12554

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Microsome

# Metabolic_Enzyme_3_Gene_Sequence:
>1590 bp
ATGTCTGTGAAATGGACTTCAGTAATTTTGCTAATACAACTGAGCTTTTGCTTTAGCTCT
GGGAATTGTGGAAAGGTGCTGGTGTGGGCAGCAGAATACAGCCATTGGATGAATATAAAG
ACAATCCTGGATGAGCTTATTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAACAACTCATCCGCTCTTAAAATTGAAATTTATCCCACATCT
TTAACTAAAACTGAGTTGGAGAATTTCATCATGCAACAGATTAAGAGATGGTCAGACCTT
CCAAAAGATACATTTTGGTTATATTTTTCACAAGTACAGGAAATCATGTCAATATTTGGT
GACATAACTAGAAAGTTCTGTAAAGATGTAGTTTCAAATAAGAAATTTATGAAAAAAGTA
CAAGAGTCAAGATTTGACGTCATTTTTGCAGATGCTATTTTTCCCTGTAGTGAGCTGCTG
GCTGAGCTATTTAACATACCCTTTGTGTACAGTCTCAGCTTCTCTCCTGGCTACACTTTT
GAAAAGCATAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAGAA
TTAACTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTACTTT
GACTTTTGGTTCGAAATATTTGACATGAAGAAGTGGGATCAGTTTTATAGTGAAGTTCTA
GGAAGACCCACTACGTTATCTGAGACAATGGGGAAAGCTGACGTATGGCTTATTCGAAAC
TCCTGGAATTTTCAGTTTCCTCATCCACTCTTACCAAATGTTGATTTTGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTGCCTAAGGAAATGGAAGACTTTGTACAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGG
GCCAACGTAATTGCATCAGCCCTGGCCCAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATACCTTAGGTCTCAATACTCGGCTGTATAAGTGGATACCCCAGAAT
GACCTTCTAGGTCATCCAAAGACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TACGAGGCAATCTACCATGGGATCCCTATGGTGGGGATTCCATTGTTTGCCGATCAACCT
GATAACATTGCTCACATGAAGGCCAGGGGAGCAGCTGTTAGAGTGGACTTCAACACAATG
TCGAGTACAGACTTGCTGAATGCATTGAAGAGAGTAATTAATGATCCTTCATATAAAGAG
AATGTTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCTAAACACCTTCGGGTTGCAGCC
CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGTCTGT
GTGGCAACTGTGATATTTATCGTCACAAAATGTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGCAAAGAAGGGAAAAAATGATTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
J05428

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_3_Locus:
4q13

# Metabolic_Enzyme_3_SNPs:
rs7439366; rs12233719; rs35590824; rs7438284; rs4348159; rs4292394; rs28365062; rs5013211; rs7686056; rs6600884; rs7441750; rs7439152; rs12513195; rs4293848; rs3924192; rs7442453; rs7698846; rs7678656; rs12506962; rs7441774; rs6600888; rs6858558; rs6600885; rs6600891; rs7375178; rs7435335; rs6600890; rs6600887; rs7438244; rs4521414; rs6600889; rs12647682; rs7434332; rs12508257; rs4694628; rs6600886; rs4314347; rs12647681; rs7439326; rs7698645; rs12512526; rs10028494; rs9995928; rs3924194; rs6600892; rs4364327; rs3924193; rs12642938; rs4337789; rs7679184; rs12648462; rs10050146; rs4257713; rs4588522; rs4356975; rs7693957; rs7658752; rs4314345; rs7438942; rs4351080; rs4541594; rs10006452; rs6851533; rs6600880; rs7438135; rs11940316; rs6600879; rs7668282; rs7668258; rs4538548; rs6600883; rs6600893; rs7662029; rs4455491; rs11940220; rs4554144; rs5859163; rs34620993; rs34851008; rs34308305; rs34661811; rs35327868; rs35893826; rs10022440; rs13136922; rs34407256; rs35452834; rs34095769; rs5859161; rs34241812; rs34302283; rs34386959; rs35475910; rs34561399; rs28675300; rs34556519; rs28673873; rs35185848; rs28539948; rs34571475; rs34318523; rs35402056; rs5859162; rs34182209; rs4694177; rs28375964; rs35605246; rs11302069; rs10008743; rs5859160; rs4356974; rs34630750; rs7437605; rs6819882; rs34590280; rs11249527; rs11249528; rs12506592; rs13118991; rs13135225; rs28365063; rs4274916; rs4358465; rs4434330; rs4535394; rs4694169; rs6422323; rs6422324; rs6600876; rs6843382; rs7437174; rs7657423; rs7676472

# Metabolic_Enzyme_3_General_References:
2159463; 11186130

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5731

# Metabolic_Enzyme_4_Name:
UDP-glucuronosyltransferase 2B17 precursor

# Metabolic_Enzyme_4_Synonyms:
UDPGT; C19- steroid-specific UDP-glucuronosyltransferase

# Metabolic_Enzyme_4_Gene_Name:
UGT2B17

# Metabolic_Enzyme_4_Protein_Sequence:
>UDPglucuronosyltransferase 2B17 precursor
MSLKWMSVFLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSA
SILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEY
SDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYT
VEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEV
LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
MSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVA
AHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLFCFRKLAKTGKKKKRD

# Metabolic_Enzyme_4_Number_of_Residues:
530

# Metabolic_Enzyme_4_Molecular_Weight:
61096

# Metabolic_Enzyme_4_Theoretical_pI:
8.73

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3alpha,17beta-diol (3alpha-diol) > testosterone > androsterone (ADT)

# Metabolic_Enzyme_4_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_4_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_4_Signals:
1-23

# Metabolic_Enzyme_4_Transmembrane_Regions:
495-515

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_4_GenBank_ID_Protein:
3287473

# Metabolic_Enzyme_4_SwissProt_ID:
UDB17_HUMAN (O75795)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
UGT2B17

# Metabolic_Enzyme_4_Geneatlas_id:
UGT2B17

# Metabolic_Enzyme_4_hgnc_id:
HGNC:12547

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Microsome

# Metabolic_Enzyme_4_Gene_Sequence:
>1593 bp
ATGTCTCTGAAATGGATGTCAGTCTTTCTGCTGATGCAGCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATACAGCCATTGGATAAATATGAAG
ACAATCCTGGAAGAGCTTGTTCAGAGGGGTCATGAGGTGATTGTGTTGACATCTTCGGCT
TCTATTCTTGTCAATGCCAGTAAATCATCTGCTATTAAATTAGAAGTTTATCCTACATCT
TTAACTAAAAATGATTTGGAAGATTTTTTTATGAAAATGTTCGATAGATGGACATATAGT
ATTTCAAAAAATACATTTTGGTCATATTTTTCACAACTACAAGAATTGTGTTGGGAATAT
TCTGACTATAATATAAAGCTCTGTGAAGATGCAGTTTTGAACAAGAAACTTATGAGAAAA
CTACAAGAGTCAAAATTTGATGTCCTTCTGGCAGATGCCGTTAATCCCTGTGGTGAGCTG
CTGGCTGAACTACTTAACATACCCTTTCTGTACAGTCTCCGCTTCTCTGTTGGCTACACA
GTTGAGAAGAATGGTGGAGGATTTCTGTTCCCTCCTTCCTATGTACCTGTTGTTATGTCA
GAATTAAGTGATCAAATGATTTTCATGGAGAGGATAAAAAATATGATATATATGCTTTAT
TTTGACTTTTGGTTTCAAGCATATGATCTGAAGAAGTGGGACCAGTTTTATAGTGAAGTT
CTAGGAAGACCCACTACATTATTTGAGACAATGGGGAAAGCTGAAATGTGGCTCATTCGA
ACCTATTGGGATTTTGAATTTCCTCGCCCATTCTTACCAAATGTTGATTTTGTTGGAGGA
CTTCACTGTAAACCAGCCAAACCCTTGCCTAAGGAAATGGAAGAGTTTGTGCAGAGCTCT
GGAGAAAATGGTATTGTGGTGTTTTCTCTGGGGTCGATGATCAGTAACATGTCAGAAGAA
AGTGCCAACATGATTGCATCAGCCCTTGCCCAGATCCCACAAAAGGTTCTATGGAGATTT
GATGGCAAGAAGCCAAATACTTTAGGTTCCAATACTCGACTGTATAAGTGGTTACCCCAG
AATGACCTTCTTGGTCATCCCAAAACCAAAGCTTTTATAACTCATGGTGGAACCAATGGC
ATCTATGAGGCGATCTACCATGGGATCCCTATGGTGGGCATTCCCTTGTTTGCGGATCAA
CATGATAACATTGCTCACATGAAAGCCAAGGGAGCAGCCCTCAGTGTGGACATCAGGACC
ATGTCAAGTAGAGATTTGCTCAATGCATTGAAGTCAGTCATTAATGACCCTATCTATAAA
GAGAATATCATGAAATTATCAAGAATTCATCATGATCAACCGGTGAAGCCCCTGGATCGA
GCAGTCTTCTGGATTGAGTTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTCGCA
GCCCACAACCTCACCTGGATCCAGTACCACTCTTTGGATGTGATAGCATTCCTGCTGGCC
TGCGTGGCAACTATGATATTTATGATCACAAAATGTTGCCTGTTTTGTTTCCGAAAGCTT
GCCAAAACAGGAAAGAAGAAGAAAAGGGATTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
U59209

# Metabolic_Enzyme_4_Chromosome_Location:
Not Available

# Metabolic_Enzyme_4_Locus:
Not Available

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
8798464; 9364925

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5720

# Metabolic_Enzyme_5_Name:
UDP-glucuronosyltransferase 2B10 precursor

# Metabolic_Enzyme_5_Synonyms:
UDPGT

# Metabolic_Enzyme_5_Gene_Name:
UGT2B10

# Metabolic_Enzyme_5_Protein_Sequence:
>UDPglucuronosyltransferase 2B10 precursor
MALKWTTVLLIQLSFYFSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSAS
ILFDPNDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEILWAIND
IIRNFCKDVVSNKKLMKKLQESRFDIVFADAYLPCGELLAELFNIPFVYSHSFSPGYSFE
RHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWFQIFNMKKWDQFYSEVLG
RPTTLSETMRKADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGE
NGVVVFSLGSMVSNMTEERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQND
LLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMS
STDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAH
NLTWFQYHSLDVIGFLLACVATVLFIITKCCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_5_Number_of_Residues:
528

# Metabolic_Enzyme_5_Molecular_Weight:
60775

# Metabolic_Enzyme_5_Theoretical_pI:
9.40

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_5_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_5_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_5_Signals:
1-23

# Metabolic_Enzyme_5_Transmembrane_Regions:
492-512

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_5_GenBank_ID_Protein:
516150

# Metabolic_Enzyme_5_SwissProt_ID:
UDB10_HUMAN (P36537)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
UGT2B10

# Metabolic_Enzyme_5_Geneatlas_id:
UGT2B10

# Metabolic_Enzyme_5_hgnc_id:
HGNC:12544

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Microsome

# Metabolic_Enzyme_5_Gene_Sequence:
>1587 bp
ATGGCTCTGAAATGGACTACAGTTCTGCTGATACAACTCAGTTTTTACTTTAGCTCTGGG
AGTTGTGGAAAGGTGCTGGTATGGGCCGCAGAATACAGCCTTTGGATGAATATGAAGACA
ATCCTGAAAGAACTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCTTCC
ATTCTTTTTGATCCCAACGACTCATCCACTCTTAAACTTGAAGTTTATCCTACATCTTTA
ACTAAAACTGAATTTGAGAATATCATCATGCAATTGGTTAAGAGATTGTCAGAAATTCAA
AAAGATACATTTTGGTTACCTTTTTCACAAGAACAAGAAATCCTGTGGGCAATTAATGAC
ATAATTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAACTTATGAAAAAACTACAA
GAGTCAAGATTTGACATCGTTTTTGCAGATGCTTATTTACCCTGTGGTGAGCTGCTGGCT
GAGCTATTTAACATACCCTTTGTGTACAGTCACAGCTTCAGTCCTGGCTACTCATTTGAA
AGGCACAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAAAATTA
AGTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGCTCTATGTGCTTTATTTTGAC
TTTTGGTTCCAAATATTTAATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTAGGA
AGACCCACTACATTATCTGAGACAATGAGGAAAGCTGACATATGGCTTATGCGAAACTCC
TGGAATTTTAAATTTCCTCATCCATTCTTACCAAATGTTGATTTTGTTGGAGGACTCCAC
TGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAGTTTGTACAGAGCTCTGGAGAA
AATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGGGCC
AACGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTTTGGAGATTTGATGGG
AATAAACCAGATGCCTTAGGTCTCAATACTCGACTGTACAAGTGGATACCCCAGAATGAC
CTTCTAGGTCATCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATCTAT
GAGGCAATCTACCATGGGATCCCTATGGTGGGCATTCCATTGTTTTTTGATCAACCTGAT
AATATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGAGTGGACTTCAACACAATGTCG
AGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTCATATAAAGAGAAT
ATTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCAGTC
TTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCCAAACATCTTCGAGTTGCAGCCCAC
AACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGCTTGTGTG
GCAACCGTGCTATTTATCATCACAAAGTGTTGTCTGTTTTGTTTCTGGAAGTTTGCTAGA
AAAGGAAAGAAGGGAAAAAGGGATTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X63359

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_5_Locus:
4q13.2

# Metabolic_Enzyme_5_SNPs:
rs3208727; rs17146903; rs17146904; rs835313; rs835316; rs835309; rs861340; rs844342; rs1841042; rs294778; rs835311; rs2670431; rs294777; rs835317; rs7676529; rs835310; rs11726322; rs11249509; rs1968764; rs7676146; rs1849533; rs17146894; rs835314; rs294772; rs9917967; rs2054221; rs3792628; rs1849534; rs1913316; rs7657958; rs1913315; rs2926036; rs835312; rs1913317; rs4694343; rs835319; rs7673996; rs2670430; rs835315; rs4694344; rs1913318; rs7670334; rs1913320; rs11940320; rs294776; rs4694358; rs294775; rs1976666; rs4095564; rs9917968; rs2942857; rs4116824; rs3215212; rs28563143; rs1902931; rs13111730; rs12506094; rs1979281; rs11347207; rs34334121; rs12511664; rs5859144; rs5859145; rs13141448; rs4116823; rs28377589; rs35887929; rs36003814; rs34999460; rs7678703; rs9917930; rs35390620; rs1902932; rs7674011; rs6839369; rs10007687; rs4095563; rs5859146; rs1902930; rs13148664; rs33938096; rs13110924; rs5859147; rs7685333; rs28586884; rs10428371; rs294771; rs13132114; rs6839806; rs34291505; rs13131461; rs13132118; rs13114078; rs4116825; rs13111722; rs835318; rs17146905; rs34183546; rs35690388; rs11725502; rs35525464; rs11729424; rs11737566; rs11737644; rs1379809; rs1458232; rs1458233; rs294765; rs294770; rs4450999; rs4694340; rs6816491; rs6836993; rs6843220

# Metabolic_Enzyme_5_General_References:
8333863

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5734

# Metabolic_Enzyme_6_Name:
UDP-glucuronosyltransferase 2B11 precursor

# Metabolic_Enzyme_6_Synonyms:
UDPGT

# Metabolic_Enzyme_6_Gene_Name:
UGT2B11

# Metabolic_Enzyme_6_Protein_Sequence:
>UDPglucuronosyltransferase 2B11 precursor
MTLKWTSVLLLIHLSCYFSSGSCGKVLVWAAEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDASTLKFEVYPTSLTKTEFENIIMQQVKRWSDIRKDSFWLYFSQEQEILWELY
DIFRNFCKDVVSNKKVMKKLQESRFDIVFADAVFPCGELLAALLNIRFVYSLRFTPGYTI
ERHSGGLIFPPSYIPIVMSKLSDQMTFMERVKNMIYVLYFDFWFQMSDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNVDFVGGFHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRLDFNTM
SSTDLLNALKTVINDPLYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMPHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLACVATVIFIITKFCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_6_Number_of_Residues:
529

# Metabolic_Enzyme_6_Molecular_Weight:
61039

# Metabolic_Enzyme_6_Theoretical_pI:
9.29

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_6_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_6_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_6_Signals:
1-21

# Metabolic_Enzyme_6_Transmembrane_Regions:
493-513

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_6_GenBank_ID_Protein:
3360273

# Metabolic_Enzyme_6_SwissProt_ID:
UDB11_HUMAN (O75310)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
UGT2B11

# Metabolic_Enzyme_6_Geneatlas_id:
UGT2B11

# Metabolic_Enzyme_6_hgnc_id:
HGNC:12545

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Microsome

# Metabolic_Enzyme_6_Gene_Sequence:
>1590 bp
ATGACTCTGAAATGGACTTCAGTTCTTCTGCTGATACATCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAAGTGCTGGTGTGGGCCGCAGAATACAGCCATTGGATGAATATGAAG
ACAATCCTGAAAGAGCTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAATGATGCATCCACTCTTAAATTTGAAGTTTATCCTACATCT
TTAACTAAAACTGAATTTGAGAATATCATCATGCAACAGGTTAAGAGATGGTCAGACATT
CGAAAAGATAGCTTTTGGTTATATTTTTCACAAGAACAAGAAATCCTGTGGGAATTATAT
GACATATTTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAAGTTATGAAAAAACTA
CAAGAGTCAAGATTTGACATCGTTTTTGCAGATGCTGTTTTTCCCTGTGGTGAGCTGCTG
GCTGCGCTACTTAACATACGGTTTGTGTACAGTCTCCGCTTTACTCCTGGCTACACAATT
GAAAGGCACAGTGGAGGACTGATTTTCCCTCCTTCCTACATACCTATTGTTATGTCAAAA
TTAAGTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTATTTT
GACTTTTGGTTCCAAATGTCTGATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTA
GGAAGACCCACTACCTTATTTGAGACAATGGGAAAAGCTGACATATGGCTTATGCGAAAC
TCCTGGAGTTTTCAATTTCCTCATCCATTCTTACCAAACGTTGATTTTGTTGGAGGATTC
CACTGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAGTTTGTACAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAGTGATAAGTAACATGACAGCAGAAAGG
GCCAATGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAC
GGGAATAAACCAGATGCCTTAGGTCTCAATACTCGGCTGTACAAGTGGATACCCCAGAAT
GACCTTCTAGGTCATCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATGAGGCAATCTACCATGGGATCCCTATGGTGGGCATTCCATTGTTTTTTGATCAACCT
GATAACATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGATTGGACTTCAACACAATG
TCGAGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTTATATAAAGAG
AATATTATGAAATTATCAAGAATTCAACATGATCAACCAGTAAAGCCCCTGGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCCCCACAAAGGAGCCAAACACCTTCGAGTTGCAGCC
CATGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTTCTGCTGGCCTGT
GTGGCAACTGTGATATTTATCATCACAAAGTTTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGGGAAGAAGGGAAAAAGAGATTAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AF016492

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_6_Locus:
4q13.2

# Metabolic_Enzyme_6_SNPs:
rs4694697; rs4415023; rs4400059; rs4543201; rs4283741; rs11945946; rs7436729; rs11947293; rs4463131; rs6833028; rs12500268; rs4608875; rs7688262; rs7697037; rs3890590; rs7697482; rs35248576; rs11340393; rs5859168; rs4485863; rs28743034; rs4619960; rs13148581; rs13113479; rs4406085; rs34519957; rs13119196; rs28561592; rs4406086; rs13134572; rs7660257; rs13148525; rs35902951; rs13148376; rs4386666; rs13134364; rs13113695; rs4485864; rs13107183; rs7660248; rs13119170; rs13103028; rs13134363; rs35555504; rs13139597; rs35443238; rs28470680; rs13113271; rs13119197; rs13107219; rs10007587; rs4466107; rs10434518; rs34416320; rs10007579; rs6847476; rs10012181; rs9996390; rs12502502; rs13123057; rs4526045; rs4694199; rs6817250; rs6825376; rs7672567; rs7682460; rs7695331

# Metabolic_Enzyme_6_General_References:
9675083

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5696

# Metabolic_Enzyme_7_Name:
UDP-glucuronosyltransferase 2B4 precursor

# Metabolic_Enzyme_7_Synonyms:
UDPGT; Hyodeoxycholic acid; HLUG25; UDPGTh-1

# Metabolic_Enzyme_7_Gene_Name:
UGT2B4

# Metabolic_Enzyme_7_Protein_Sequence:
>UDPglucuronosyltransferase 2B4 precursor
MSMKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLASSA
SISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFN
DILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFGELLAELLKIPFVYSLRFSPGYAI
EKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVL
GRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSMVSNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTM
SSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVTGFLLACVATVIFIITKCLFCVWKFVRTGKKGKRD

# Metabolic_Enzyme_7_Number_of_Residues:
528

# Metabolic_Enzyme_7_Molecular_Weight:
60513

# Metabolic_Enzyme_7_Theoretical_pI:
8.75

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid

# Metabolic_Enzyme_7_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_7_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_7_Signals:
1-23

# Metabolic_Enzyme_7_Transmembrane_Regions:
493-509

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_7_GenBank_ID_Protein:
37589

# Metabolic_Enzyme_7_SwissProt_ID:
UDB4_HUMAN (P06133)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
UGT2B4

# Metabolic_Enzyme_7_Geneatlas_id:
UGT2B4

# Metabolic_Enzyme_7_hgnc_id:
HGNC:12553

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Microsome

# Metabolic_Enzyme_7_Gene_Sequence:
>1587 bp
ATGTCTATGAAATGGACTTCAGCTCTTCTGCTGATACAGCTGAGCTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATTCAGCCACTGGATGAATATAAAG
ACAATCCTGGATGAACTTGTCCAGAGAGGTCATGAGGTGACTGTATTGGCATCTTCAGCT
TCCATTTCTTTCGATCCCAACAGCCCATCTACTCTTAAATTTGAAGTTTATCCTGTATCT
TTAACTAAAACTGAGTTTGAGGATATTATCAAGCAGCTGGTTAAGAGATGGGCAGAACTT
CCAAAAGACACATTTTGGTCATATTTTTCACAAGTACAAGAAATCATGTGGACATTTAAT
GACATACTTAGAAAGTTCTGTAAGGATATAGTTTCAAATAAGAAACTTATGAAGAAACTA
CAGGAGTCAAGATTTGATGTTGTTCTTGCAGATGCTGTTTTCCCCTTTGGTGAGCTGCTG
GCCGAGTTACTTAAAATACCCTTTGTCTACAGGCCTCGCTTCTCTCCTGGCTACGCAATT
GAAAAGCATAGTGGAGGACTTCTGTTCCCTCCTTCCTATGTGCCTGTTGTTATGTCAGAA
CTAAGTGACCAAATGACTTTCATAGAGAGGGTAAAAAATATGATCTATGTGCTTTATTTT
GAATTTTGGTTCCAAATATTTGACATGAAGAAGTGGGATCAGTTCTACAGTGAAGTTCTA
GGAAGACCCACTACGTTATCTGAGACAATGGCAAAAGCTGACATATGGCTTATTCGAAAC
TACTGGGATTTTCAATTTCCTCACCCACTCTTACCAAATGTTGAGTTCGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTACCGAAGGAAATGGAAGAGTTTGTCCAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCGATGGTCAGTAACACGTCAGAAGAAAGG
GCCAATGTAATTGCATCAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATACTTTAGGACTCAATACTCGGCTGTACAAGTGGATACCCCAGAAT
GATCTTCTTGGTCACCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATAAGGCAATCTCTCCTAGAATCCCTATGGTGGGCGTTCCATTGTTTGCAGATCAACCT
GATAACATTGCACACATGAAGGCCAAGGGAGCAGCTGTTAGTTTGGACTTCCACACAATG
TCGAGTACAGACTTACTCAATGCACTGAAGACAGTAATTAATGATCCTTTATATAAAGAG
AATGCTATGAAATTATCAAGAATTCATCATGATCAACCAGTGAAGCCCCTTGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTTGCAGCC
CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGACTGGGTTCCTGCTGGCCTGT
GTGGCAACTGTGATATTCATCATCACAAAATGTCTGTTTTGTGTCTGGAAGTTTGTTAGA
ACAGGAAAGAAGGGGAAAAGAGATTAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
Y00317

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_7_Locus:
4q13

# Metabolic_Enzyme_7_SNPs:
rs13119049; rs41297431; rs13142440; rs1131878; rs1966151; rs1051752; rs7662902; rs1389930; rs1826690; rs7441743; rs1039007; rs2220857; rs2013562; rs1845557; rs6833511; rs13116232; rs12645716; rs9997034; rs1994936; rs1039008; rs4554145; rs28542932; rs10030234; rs10518061; rs17614939; rs13104260; rs10010875; rs3822179; rs33914959; rs1845556; rs6848208; rs17671289; rs1977017; rs28361541; rs41297733; rs41297437; rs1997581; rs41297373; rs41299996; rs41297395; rs41297371; rs41300016; rs41297381; rs41297421; rs1908406; rs41297427; rs41297377; rs41297425; rs41297367; rs4557343; rs1845558; rs3075630; rs41297405; rs41297739; rs41297383; rs41297721; rs13151870; rs41297441; rs13145834; rs13104687; rs11249442; rs41297407; rs41297429; rs41297727; rs1121124; rs2013573; rs41299994; rs13139888; rs41297439; rs41297409; rs1494802; rs13111134; rs6600771; rs6820660; rs6821129; rs941389; rs2736446; rs1080755; rs2736442; rs28858389; rs2736441; rs41298271; rs41298263; rs41299972; rs41298261; rs41298251; rs13129471; rs41299970; rs6821910; rs41298253; rs41298259; rs41298265; rs41298245; rs41299978; rs41299976; rs41299974; rs41300004; rs17852375; rs1845555; rs41298247; rs28679647; rs324405; rs41300006; rs36048401; rs1432328; rs41297387; rs41299984; rs41299998; rs41299992; rs41297735; rs41297423; rs35143721; rs1370886; rs41299980; rs41297389; rs41297729; rs7441132; rs41297435; rs34002802; rs41297731; rs41300018; rs35138624; rs41297391; rs41297369; rs41297737; rs41297413; rs13141359; rs41292303; rs41300008; rs2736447; rs41300014; rs41297401; rs34874998; rs1370887; rs41297399; rs41297379; rs172861; rs41297375; rs10613760; rs41297433; rs41297723; rs41297403; rs41297741; rs1821190; rs34030380; rs324406; rs41299986; rs41297393; rs41297385; rs41297419; rs41297365; rs35471760; rs34861432; rs4515233; rs324408; rs41297411; rs2018304; rs41300012; rs13114834; rs41297415; rs28629208; rs41300002; rs41300000; rs41300010; rs41297743; rs41297397; rs41299990; rs28419590; rs983988; rs34164957; rs1370885; rs324407; rs34466016; rs41297725; rs41297417; rs34114694; rs41299988; rs41299982; rs41299966; rs34846583; rs35045255; rs35834953; rs34169605; rs1318156; rs2642856; rs35159034; rs41298257; rs41298249; rs2736445; rs3075626; rs41299968; rs28847667; rs34146174; rs36057237; rs28812576; rs941390; rs41298255; rs28894673; rs41298269; rs1080756; rs41298267; rs10000231; rs10015297; rs11725944; rs11725945; rs13141436; rs13143630; rs1569343; rs1569344; rs1594588; rs1603119; rs1948499; rs2010468; rs2642849; rs2642872; rs2736462; rs2736476; rs2736517; rs2736520; rs35347166; rs4694749; rs7657880; rs903445; rs903446; rs9996511

# Metabolic_Enzyme_7_General_References:
3109396; 8333863; 10376768

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5725

# Metabolic_Enzyme_8_Name:
UDP-glucuronosyltransferase 1-1 precursor

# Metabolic_Enzyme_8_Synonyms:
UDP- glucuronosyltransferase 1A1; UDPGT; UGT1*1; UGT1-01; UGT1.1; UGT- 1A; UGT1A; Bilirubin-specific UDPGT isozyme 1; HUG-BR1

# Metabolic_Enzyme_8_Gene_Name:
UGT1A1

# Metabolic_Enzyme_8_Protein_Sequence:
>UDPglucuronosyltransferase 11 precursor
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_8_Number_of_Residues:
533

# Metabolic_Enzyme_8_Molecular_Weight:
59592

# Metabolic_Enzyme_8_Theoretical_pI:
8.09

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

# Metabolic_Enzyme_8_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_8_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_8_Signals:
1-25

# Metabolic_Enzyme_8_Transmembrane_Regions:
491-507

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_8_GenBank_ID_Protein:
184473

# Metabolic_Enzyme_8_SwissProt_ID:
UD11_HUMAN (P22309)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
UGT1A1

# Metabolic_Enzyme_8_Geneatlas_id:
UGT1A1

# Metabolic_Enzyme_8_hgnc_id:
HGNC:12530

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Microsome

# Metabolic_Enzyme_8_Gene_Sequence:
>1602 bp
ATGGCTGTGGAGTCCCAGGGCGGACGCCCACTTGTCCTGGGCCTGCTGCTGTGTGTGCTG
GGCCCAGTGGTGTCCCATGCTGGGAAGATACTGTTGATCCCAGTGGATGGCAGCCACTGG
CTGAGCATGCTTGGGGCCATCCAGCAGCTGCAGCAGAGGGGACATGAAATAGTTGTCCTA
GCACCTGACGCCTCGTTGTACATCAGAGACGGAGCATTTTACACCTTGAAGACGTACCCT
GTGCCATTCCAAAGGGAGGATGTGAAAGAGTCTTTTGTTAGTCTCGGGCATAATGTTTTT
GAGAATGATTCTTTCCTGCAGCGTGTGATCAAAACATACAAGAAAATAAAAAAGGACTCT
GCTATGCTTTTGTCTGGCTGTTCCCACTTACTGCACAACAAGGAGCTCATGGCCTCCCTG
GCAGAAAGCAGCTTTGATGTCATGCTGACGGACCCTTTCCTTCCTTGCAGCCCCATCGTG
GCCCAGTACCTGTCTCTGCCCACTGTATTCTTCTTGCATGCACTGCCATGCAGCCTGGAA
TTTGAGGCTACCCAGTGCCCCAACCCATTCTCCTACGTGCCCAGGCCTCTCTCCTCTCAT
TCAGATCACATGACCTTCCTGCAGCGGGTGAAGAACATGCTCATTGCCTTTTCACAGAAC
TTTCTGTGCGACGTGGTTTATTCCCCGTATGCAACCCTTGCCTCAGAATTCCTTCAGAGA
GAGGTGACTGTCCAGGACCTATTGAGCTCTGCATCTGTCTGGCTGTTTAGAAGTGACTTT
GTGAAGGATTACCCTAGGCCCATCATGCCCAATATGGTTTTTGTTGGTGGAATCAACTGC
CTTCACCAAAATCCACTATCCCAGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACAT
GGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATG
GCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACC
CGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTG
CTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAA
AGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAAT
GCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCT
GAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATC
ATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTC
TGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGAC
CTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTG
ACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAA
AAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
M57899

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_8_Locus:
2q37

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
1898728; 1339448; 11434514; 1634050; 8280139; 8276413; 8226884; 7989045; 7989595; 7715297; 9621515; 9627603

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5687

# Metabolic_Enzyme_9_Name:
UDP-glucuronosyltransferase 2B28 precursor

# Metabolic_Enzyme_9_Synonyms:
UDPGT

# Metabolic_Enzyme_9_Gene_Name:
UGT2B28

# Metabolic_Enzyme_9_Protein_Sequence:
>UDPglucuronosyltransferase 2B28 precursor
MALKWTSVLLLIHLGCYFSSGSCGKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDIQKDSFWLYFSQEQEILWEFH
DIFRNFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTI
ERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWFQMCDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTM
SSTDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAA
RDLTWFQYHSLDVIGFLLACVATVIFVVTKFCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_9_Number_of_Residues:
529

# Metabolic_Enzyme_9_Molecular_Weight:
60907

# Metabolic_Enzyme_9_Theoretical_pI:
8.80

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta- diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active

# Metabolic_Enzyme_9_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_9_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_9_Signals:
1-24

# Metabolic_Enzyme_9_Transmembrane_Regions:
495-517

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_9_GenBank_ID_Protein:
13603476

# Metabolic_Enzyme_9_SwissProt_ID:
UDB28_HUMAN (Q9BY64)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
UGT2B28

# Metabolic_Enzyme_9_Geneatlas_id:
UGT2B28

# Metabolic_Enzyme_9_hgnc_id:
HGNC:13479

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Microsome

# Metabolic_Enzyme_9_Gene_Sequence:
>1590 bp
ATGGCTCTGAAGTGGACTTCAGTTCTTCTGCTGATACATCTCGGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGACCGGTGAATACAGCCATTGGATGAATATGAAG
ACAATCCTGAAAGAGCTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAATGACGCATTCACTCTTAAACTCGAAGTTTATCCTACATCT
TTAACTAAAACTGAATTTGAGAATATCATCATGCAACAGGTTAAGAGATGGTCAGACATT
CAAAAAGATAGCTTTTGGTTATATTTTTCACAAGAACAAGAAATCCTGTGGGAATTTCAT
GACATATTTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAAGTTATGAAAAAACTA
CAAGAGTCAAGATTTGACATCATTTTTGCAGATGCTTTTTTTCCTTGTGGTGAGCTGCTG
GCTGCGCTACTTAACATACCGTTTGTGTACAGTCTCTGCTTCACTCCTGGCTACACAATT
GAAAGGCACAGTGGAGGACTGATTTTCCCTCCTTCCTACATACCTGTTGTTATGTCAAAA
TTAAGTGATCAAATGACTTTCATGGAGAGGGTAAAAAACATGATCTATGTGCTTTATTTT
GACTTTTGGTTCCAAATGTGTGATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTA
GGAAGACCCACTACCTTATTTGAGACAATGGGGAAAGCTGACATATGGCTTATGCGAAAC
TCCTGGAGTTTTCAATTTCCTCATCCATTCTTACCAAACATTGATTTTGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAATTTGTACAGAGCTCTGGT
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAGTGATAAGTAACATGACAGCAGAAAGG
GCCAACGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATGCCTTAGGTCTCAATACTCGGCTGTATAAGTGGATACCCCAGAAT
GACCTTCTAGGTCTTCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATGAGGCAATCTACCATGGGATCCCTATGGTAGGCATTCCATTGTTTTGGGATCAACCT
GATAACATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGACTGGACTTCCACACAATG
TCGAGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTCATATAAAGAG
AATGTTATGAAATTATCAATAATTCAACATGATCAACCAGTAAAGCCCCTGCATCGAGCA
GTCTTCTGGATTGAATTTGTGATGTGCCACAAAGGAGCCAAACACCTTCGAGTTGCAGCC
CGTGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTTCTGCTGGCCTGT
GTGGCAACTGTGATATTTGTCGTCACAAAGTTTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGGGAAGAAGGGAAAAAGAGATTAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AF177272

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_9_Locus:
4q13.2

# Metabolic_Enzyme_9_SNPs:
rs4235127; rs4260604; rs4386668; rs11726210; rs10002503; rs4235126; rs3901337; rs4260603; rs10008843; rs4694712; rs4301173; rs4694711; rs2132039; rs9997242; rs4260602; rs4235125; rs4694713; rs7686786; rs10000077; rs7437560; rs7681187; rs10023367; rs7657406; rs41292949; rs6843900; rs6828191; rs41292951; rs10013145; rs7689398; rs41292341; rs13139691; rs13138824; rs4569811; rs6827801; rs34313836; rs5004177; rs28376412; rs13108235; rs5004180; rs4295327; rs4568294; rs4450998; rs33966513; rs5004176; rs35191928; rs13107778; rs4345242; rs34549399; rs4495113; rs5004183; rs41292945; rs41292947; rs35437714; rs35925451; rs13146763; rs28447469; rs35059283; rs5004182; rs7435249; rs5004175; rs5859170; rs4515230; rs6840320; rs35572829; rs5004178; rs5004179; rs4597901; rs41292339; rs5004181; rs13116501; rs10011666; rs41292343; rs7657045; rs13124875; rs9991645; rs35680160; rs6600920

# Metabolic_Enzyme_9_General_References:
11300766

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5719

# Metabolic_Enzyme_10_Name:
UDP-glucuronosyltransferase 1-4 precursor

# Metabolic_Enzyme_10_Synonyms:
UDP- glucuronosyltransferase 1A4; UDPGT; UGT1*4; UGT1-04; UGT1.4; UGT- 1D; UGT1D; Bilirubin-specific UDPGT isozyme 2; HUG-BR2

# Metabolic_Enzyme_10_Gene_Name:
UGT1A4

# Metabolic_Enzyme_10_Protein_Sequence:
>UDPglucuronosyltransferase 14 precursor
MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVV
LTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNV
SLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDL
DFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQ
REVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_10_Number_of_Residues:
534

# Metabolic_Enzyme_10_Molecular_Weight:
60026

# Metabolic_Enzyme_10_Theoretical_pI:
8.68

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

# Metabolic_Enzyme_10_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_10_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_10_Signals:
1-28

# Metabolic_Enzyme_10_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_10_GenBank_ID_Protein:
340137

# Metabolic_Enzyme_10_SwissProt_ID:
UD14_HUMAN (P22310)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
UGT1A4

# Metabolic_Enzyme_10_Geneatlas_id:
UGT1A4

# Metabolic_Enzyme_10_hgnc_id:
HGNC:12536

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Microsome

# Metabolic_Enzyme_10_Gene_Sequence:
>867 bp
ATGGCCAGAGGACTCCAGGTTCCCCTGCCGCGGCTGGCCACAGGACTGCTGCTCCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCACTGATGGCAGCCCC
TGGCTCAGCATGCGGGAGGCCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCGGTGGTC
CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAAATTTTTCACCCTGACAGCCTAT
GCTGTTCCATGGACCCAGAAGGAATTTGATCGCGTTACGCTGGGCTACACTCAAGGGTTC
TTTGAAACAGAACATCTTCTGAAGAGATATTCTAGAAGTATGGCAATTATGAACAATGTA
TCTTTGGCCCTTCATAGGTGTTGTGTGGAGCTACTGCATAATGAGGCCCTGATCAGGCAC
CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGTGGGGCGGTG
CTGGCTAAGTACCTGTCGATTCCTGCTGTGTTTTTTTGGAGGTACATTCCATGTGACTTA
GACTTTAAGGGCACACAGTGTCCAAATCCTTCCTCCTATATTCCTAAGTTACTAACGACC
AATTCAGACCACATGACATTCCTGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACATTTGCCATACTTTTTCTGCCCCTTATGCAAGTCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATCTTGTCAGCTATGCATCCGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGACTACCCCAGGCCGATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACGGGAAGCCACTATCTCAG

# Metabolic_Enzyme_10_GenBank_ID_Gene:
M84128

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_10_Locus:
2q37

# Metabolic_Enzyme_10_SNPs:
Not Available

# Metabolic_Enzyme_10_General_References:
1898728; 1339448; 11434514; 1634050; 8280139; 8276413

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5728

# Metabolic_Enzyme_11_Name:
UDP-glucuronosyltransferase 1-3 precursor

# Metabolic_Enzyme_11_Synonyms:
UDP- glucuronosyltransferase 1A3; UDPGT; UGT1*3; UGT1-03; UGT1.3; UGT- 1C; UGT1C

# Metabolic_Enzyme_11_Gene_Name:
UGT1A3

# Metabolic_Enzyme_11_Protein_Sequence:
>UDPglucuronosyltransferase 13 precursor
MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVV
LTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNM
SLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDL
DFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQ
REVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_11_Number_of_Residues:
534

# Metabolic_Enzyme_11_Molecular_Weight:
60339

# Metabolic_Enzyme_11_Theoretical_pI:
8.28

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_11_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_11_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_11_Signals:
1-28

# Metabolic_Enzyme_11_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_11_GenBank_ID_Protein:
340135

# Metabolic_Enzyme_11_SwissProt_ID:
UD13_HUMAN (P35503)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
UGT1A3

# Metabolic_Enzyme_11_Geneatlas_id:
UGT1A3

# Metabolic_Enzyme_11_hgnc_id:
HGNC:12535

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Microsome

# Metabolic_Enzyme_11_Gene_Sequence:
>867 bp
ATGGCCACAGGACTCCAGGTTCCCCTGCCGTGGCTGGCCACAGGACTGCTGCTTCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCATTGATGGCAGCCAC
TGGCTCAGCATGCGGGAGGTCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCAGTGGTC
CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAACTTTTTCACCCTGACAACCTAT
GCCATTTCGTGGACCCAGGATGAATTTGATCGCCATGTGCTGGGCCACACTCAACTGTAC
TTTGAAACAGAACATTTTCTGAAGAAATTTTTCAGAAGTATGGCAATGTTGAACAATATG
TCTTTGGTCTATCATAGGTCTTGTGTGGAGCTACTACATAATGAGGCCCTGATCAGGCAC
CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGCGCGGCAGTG
CTGGCTAAGTACCTGTCGATTCCTACTGTGTTTTTTTTGAGGAACATTCCATGTGATTTA
GACTTTAAGGGCACACAGTGTCCAAACCCTTCCTCCTATATTCCTAGATTACTAACAACC
AATTCAGACCACATGACATTCATGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACATTTGCCATGCTTTTTCTGCTCCTTATGCAAGCCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATATTCTCAGTCATGCATCTGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGACTACCCCAGGCCAATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACAGGAAGCCACTATCTCAG

# Metabolic_Enzyme_11_GenBank_ID_Gene:
M84127

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_11_Locus:
2q37

# Metabolic_Enzyme_11_SNPs:
Not Available

# Metabolic_Enzyme_11_General_References:
1339448; 11434514

# Metabolic_Enzyme_11_References:
Not Available

End of HMDB00010

Beginning of HMDB00012
# Accession_No:
HMDB00012

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-23 10:30:32

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Deoxyuridine

# Description:
2'-Deoxyuridine is a naturally occurring nucleoside. It is similar in chemical structure to uridine, but without the 2'-hydroxyl group.  It is considered to be an antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemia due to vitamin B12 and folate deficiencies.

# Synonyms:
1-(2-Deoxy-D-erythro-pentofuranosyl)uracil; 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-2,4(1H,3H)-Pyrimidinedione; 1-(2-deoxy-beta-D-ribofuranosyl)-2,4(1H,3H)-Pyrimidinedione; 2'-Deoxyuridine; 2'-Desoxyuridine; Deoxyribose uracil; Desoxyuridine; Uracil deoxyriboside; Uracil desoxyuridine; 1-(2-Deoxy-delta-erythro-pentofuranosyl)uracil; 1-(2-deoxy-beta-delta-erythro-pentofuranosyl)-2,4(1H,3H)-Pyrimidinedione; 1-(2-deoxy-beta-delta-ribofuranosyl)-2,4(1H,3H)-Pyrimidinedione

# Chemical_IUPAC_Name:
1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

# Chemical_Formula:
C9H12N2O5

# Chemical_Structure:
tbl_chemical:::HMDB00012_ZOOM.png:::11928312602598488

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00012_THUMB.png:::119283125822925724

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines; Nucleosides

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; primary alcohol; secondary alcohol; oxo(het)arene; carboxylic acid imide, N-unsubstituted; urea; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
DNA component

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
228.07463

# Molecular_Weight_Avg:
228.20200

# Smiles_String_isomeric:
OC[C@H]1O[C@H](C[C@@H]1O)N2C=CC(=O)NC2=O

# Smiles_String_canonical:
OCC1OC(CC1O)N2C=CC(=O)NC2=O

# KEGG_Compound_ID:
C00526

# BioCyc_ID:
DEOXYURIDINE

# PubChem_CID:
13712

# PubChem_SID:
832124; 12034270; 3809; 8028153; 157048; 828539; 650425; 3139591; 8160335; 825013; 832930; 7887227

# OMIM_ID:
192240

# Metagene_ID:
Not Available

# BiGG_ID:
35251

# Wikipedia_ID:
Deoxyuridine

# METLIN_ID:
5086

# Ref_ID:
Akhrem, A.A. et al., Org. Magn. Reson., 1979, 12, 247, (cmr); 15866500; 9675653; Fox, J.J. et al., Adv. Carbohydr. Chem., 1959, 14, 283, (rev); Rimerman, R.A. et al., J. Chromatogr., B: Biomed. Appl., 1993, 619, 29-35, (5'-triphosphate); Schinazi, R.F. et al., J. Med. Chem., 1978, 21, 1141, (synth, acid); Barr, P.J. et al., Tetrahedron, 1980, 36, 1269, (cryst struct); Ludwig, J. et al., Synthesis, 1982, 32-34, (5'-phosphate); 3812550; Dematte, N. et al., Comp. Biochem. Physiol., B: Comp. Biochem., 1986, 84, 11, (isol, acid); Rahman, A. et al., Acta Cryst. B, 1972, 28, 2260, (cryst struct); Sakema, S. et al., Comp. Biochem. Physiol., B: Comp. Biochem., 1985, 82, 107-109, (isol); Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 816A, (ir); Kikugawa, K. et al., Chem. Pharm. Bull., 1969, 17, 785, (synth, deriv); 6656991; Sprecher, C.A. et al., Biopolymers, 1977, 16, 2243, (cd); Komori, T. et al., Annalen, 1980, 653-668, (isol); 1906076; 3761048; Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 374B, (nmr); Hruska, F.E. et al., Can. J. Chem., 1974, 52, 497, (conformn, pmr); U.S. Pat., 1966, 3 280 104, CA, 66, 38207y; Lidgren, G. et al., J. Nat. Prod., 1988, 51, 1277-1280, (2'-Deoxy-3-methyluridine); 9930567; 12638947; 2328792; 11432631

# ChEBI_ID:
16450

# CAS_Registry_Number:
951-78-0

# InChI:
InChI=1/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1

# Synthesis_Reference:
Dekker, C.A. et al., Nature (London), 1950, 166, 557, (synth); Brown, D.M. et al., J.C.S., 1958, 3035, (synth); Kikugawa, K. et al., Chem. Pharm. Bull., 1969, 17, 785, (synth, deriv); Schinazi, R.F. et al., J. Med. C hem., 1978, 21, 1141, (synth, acid); B

# Melting_Point:
167 oC

# Melting_Point_predicted:
113.2 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
29.7 mg/mL [MEYLAN,WM et al. (1996)]; 90.6 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-1.51 [BALZARINI,JM ET AL. (1989)]

# LogP_predicted:
-1.48 [Predicted by ALOGPS]; -1.5 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00526.mol:::1132723801062703623

# SDF_File_[Text]:
tbl_chemical:::HMDB00012.sdf:::11928312538948400

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00012.pdb:::119283125654529650

# PDB_ID:
1BDU

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1BDU.txt:::1132720898515975048

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041029_P00_01_HW_1DP_presat_expanded_2.gif:::114168236979070293

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041029_P00_01_HW_1DP_presat.zip:::117512426329258465

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041029_P00_01_HW_1DP_Assigned.png:::116414317220093214

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041029_P00_01_HW_2DHSQC_769.png:::114805591747188659

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041029_P00_01_HW_2DHSQC_769.zip:::114805591757798129

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041029_P00_01_HW_2DHSQC_769_Assigned.png:::115014524082864104

# Predicted_H_NMR_Spectrum:
tbl_chemical:::2'-Deoxyuridine.gif:::1132732098796116951

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00012_peaks.txt:::1156309483110986814

# Predicted_C_NMR_Spectrum:
tbl_chemical:::2'-Deoxyuridine_C.gif:::1132737657207798715

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00012_peaks.txt:::1156310675162585477

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00012L.png:::117555261809351653; Medium Energy:tbl_ms:::HMDB00012M.png:::117555266925743518; High Energy:tbl_ms:::HMDB00012H.png:::117555270818934604

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP); Extracellular; mitochondria; nucleus

# Tissue_Location:
Bladder; Bone Marrow; Fibroblasts; Intestine; Lymphocyte; Most Tissues; Muscle; Neurons; Pancreas; Placenta; Testis

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Blood	0.052 (0.049-0.056)	umol/L	Adult:>18_yrs_old	Both	Normal	15866500
Blood	0.62 +/- 0.39	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	0.200 (0.100-0.300)	umol/L	Adult:>18_yrs_old	Both	Normal	6656991
Cerebrospinal_Fluid(CSF)	0 - 0.1	uM	Adult:>18_yrs_old	Both	Normal	6656991


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Degenerative disc disease

# Pathway_Names:
Purine metabolism;Nicotinate and nicotinamide metabolism

# Pathway_Images:
Purine_Synthesis.jpg;Nicotinamide_synthesis_(NADH).jpg

# KEGG_Images:
map00230;map00760

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;Nicotinamide_synthesis_(NADH)_Graph.jpg

# Pathway_SBMLs:
Purine_Synthesis.xml;Nicotinamide_synthesis_(NADH).xml

# Metabolic_Enzyme_1_ID:
5801

# Metabolic_Enzyme_1_Name:
Uridine phosphorylase 1

# Metabolic_Enzyme_1_Synonyms:
UrdPase 1; UPase 1

# Metabolic_Enzyme_1_Gene_Name:
UPP1

# Metabolic_Enzyme_1_Protein_Sequence:
>Uridine phosphorylase 1
MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGG
SPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLH
ELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKT
DLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAY
AAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVS
YFIKKKLSKA

# Metabolic_Enzyme_1_Number_of_Residues:
310

# Metabolic_Enzyme_1_Molecular_Weight:
33935

# Metabolic_Enzyme_1_Theoretical_pI:
7.95

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
Function:  uridine phosphorylase activity
 ||
>>>
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide catabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_1_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis

# Metabolic_Enzyme_1_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_1_Reaction:
uridine + phosphate = uracil + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01048:PNP_UDP_1

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.2.3

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1050525

# Metabolic_Enzyme_1_SwissProt_ID:
UPP1_HUMAN (Q16831)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
UPP1

# Metabolic_Enzyme_1_Geneatlas_id:
UPP1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:12576

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>933 bp
ATGGCGGCCACGGGAGCCAATGCAGAGAAAGCTGAAAGTCACAATGATTGCCCCGTCAGA
CTTTTAAATCCAAACATAGCAAAAATGAAAGAAGATATTCTCTATCATTTCAATCTCACC
ACTAGCAGACACAATTTCCCAGCCTTGTTTGGAGATGTGAAGTTTGTGTGTGTTGGTGGA
AGCCCCTCCCGGATGAAAGCCTTCATCAGGTGCGTTGGTGCAGAGCTGGGCCTTGACTGC
CCAGGTAGAGACTATCCCAACATCTGTGCGGGAACTGACCGCTATGCCATGTATAAAGTA
GGACCGGTGCTGTCTGTCAGTCATGGTATGGGCATTCCTTCTATCTCAATCATGTTGCAT
GAGCTCATAAAGCTGCTGTACTATGCCCGGTGCTCCAACGTCACTATCATCCGCATTGGC
ACTTCTGGTGGGATAGGTCTGGAGCCCGGCACTGTGGTCATAACAGAGCAGGCAGTGGAT
ACCTGCTTCAAGGCAGAGTTTGAGCAGATTGTCCTGGGGAAGCGGGTCATCCGGAAAACG
GACCTTAACAAGAAGCTGGTGCAGGAGCTGTTGCTGTGTTCTGCAGAGCTGAGCGAGTTC
ACCACAGTGGTGGGGAACACCATGTGCACCTTGGACTTCTATGAAGGGCAAGGCCGTCTG
GATGGGGCTCTCTGCTCCTACACGGAGAAGGACAAGCAGGCGTATCTGGAGGCAGCCTAT
GCAGCCGGCGTCCGCAATATCGAGATGGAGTCCTCGGTGTTTGCCGCCATGTGCAGCGCC
TGCGGCCTCCAAGCGGCCGTGGTGTGTGTCACCCTCCTGAACCGCCTGGAAGGGGACCAG
ATCAGCAGCCCTCGCAATGTGCTCAGCGAGTACCAGCAGAGGCCGCAGCGGCTGGTGAGC
TACTTCATCAAGAAGAAACTGAGCAAGGCCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X90858

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_1_Locus:
7p12.3

# Metabolic_Enzyme_1_SNPs:
rs11971829; rs2230761; rs11975785; rs7458962; rs3752890; rs3763505; rs13240650; rs7459020; rs3752889; rs9639019; rs6947955; rs3763504; rs6463462; rs7341420; rs11768083; rs7385009; rs7341532; rs7459421; rs7458926; rs6944892; rs1554494; rs7793905; rs11981908; rs7794483; rs7794100; rs1131054; rs2230762; rs2230763; rs1131053; rs7798472; rs35041681; rs1050268; rs6463461; rs34459058; rs1050267; rs10278152; rs13227958; rs3763503; rs11552769; rs35225437; rs35686833; rs1050269; rs6947463; rs35169380; rs13308979; rs13228276; rs35985285; rs34080051; rs34017036; rs34743411; rs12668306; rs34556557; rs6974256; rs10260645; rs35450094; rs10225490; rs10263327; rs10274287; rs10279431; rs11971012; rs11973024; rs12672358; rs13241683; rs34702486; rs6951116; rs7778357; rs7784208; rs7804178; rs9648572

# Metabolic_Enzyme_1_General_References:
7488099

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5802

# Metabolic_Enzyme_2_Name:
Cytidine deaminase

# Metabolic_Enzyme_2_Synonyms:
Cytidine aminohydrolase

# Metabolic_Enzyme_2_Gene_Name:
CDA

# Metabolic_Enzyme_2_Protein_Sequence:
>Cytidine deaminase
MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACY
PLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKP
DGTYIVMTVQELLPSSFGPEDLQKTQ

# Metabolic_Enzyme_2_Number_of_Residues:
146

# Metabolic_Enzyme_2_Molecular_Weight:
16185

# Metabolic_Enzyme_2_Theoretical_pI:
6.95

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  cytidine deaminase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleoside metabolism
Process:  pyrimidine nucleoside metabolism
Process:  pyrimidine ribonucleoside metabolism
Process:  cytidine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis

# Metabolic_Enzyme_2_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_2_Reaction:
cytidine + H2O = uridine + ammonia

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00383:dCMP_cyt_deam_1

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.5.4.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
598149

# Metabolic_Enzyme_2_SwissProt_ID:
CDD_HUMAN (P32320)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
CDA

# Metabolic_Enzyme_2_Geneatlas_id:
CDA

# Metabolic_Enzyme_2_hgnc_id:
HGNC:1712

# Metabolic_Enzyme_2_PDB_ID:
1MQ0

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_2_Gene_Sequence:
>441 bp
ATGGCCCAGAAGCGTCCTGCCTGCACCCTGAAGCCTGAGTGTGTCCAGCAGCTGCTGGTT
TGCTCCCAGGAGGCCAAGAAGTCAGCCTACTGCCCCTACAGTCACTTTCCTGTGGGGGCT
GCCCTGCTCACCCAGGAGGGGAGAATCTTCAAAGGGTGCAACATAGAAAATGCCTGCTAC
CCGCTGGGCATCTGTGCTGAACGGACCGCTATCCAGAAGGCCGTCTCAGAAGGGTACAAG
GATTTCAGGGCAATTGCTATCGCCAGTGACATGCAAGATGATTTTATCTCTCCATGTGGG
GCCTGCAGGCAAGTCATGAGAGAGTTTGGCACCAACTGGCCCGTGTACATGACCAAGCCG
GATGGTACGTATATTGTCATGACGGTCCAGGAGCTGCTGCCCTCCTCCTTTGGGCCTGAG
GACCTGCAGAAGACTCAGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
L27943

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_2_Locus:
1p36.2-p35

# Metabolic_Enzyme_2_SNPs:
rs2072671; rs1048977; rs602950; rs1781459; rs818194; rs12402391; rs818199; rs818196; rs558946; rs580032; rs818207; rs1689924; rs10916824; rs3738130; rs527912; rs10799647; rs577042; rs10916829; rs12404655; rs818193; rs498617; rs1253920; rs572529; rs818192; rs818197; rs477155; rs589942; rs12036993; rs517483; rs10916828; rs818198; rs11579252; rs471760; rs2985316; rs7523472; rs4655226; rs6659399; rs10916825; rs7548190; rs11579101; rs12407778; rs7534998; rs11578210; rs1781461; rs12068596; rs12119998; rs11583986; rs7535303; rs10799648; rs7523547; rs10916826; rs563329; rs12406106; rs11580375; rs818200; rs12072405; rs12120002; rs7523557; rs11801036; rs588485; rs7535200; rs7513317; rs1253921; rs7537463; rs488991; rs617782; rs10916827; rs7515668; rs500534; rs557219; rs818201; rs526987; rs10916830; rs12127536; rs506586; rs7537761; rs12072407; rs2320237; rs11582454; rs12401770; rs546692; rs11580377; rs542038; rs12072411; rs10916831; rs7545140; rs472629; rs573337; rs818202; rs1253904; rs532545; rs6690069; rs10916832; rs10916833; rs10916822; rs552722; rs603412; rs17854868; rs35163879; rs3215400; rs528031; rs1048980; rs34306899; rs602946; rs35247557; rs5772909; rs35125816; rs35859441; rs36002777; rs12131589; rs34293111; rs35045423; rs36106578; rs34634228; rs35916142; rs12123808; rs12145503; rs34652519; rs12029060; rs11584381; rs35668998; rs7414028; rs35869652; rs11589869; rs9970283; rs28646077; rs35735696; rs12030776; rs12036909; rs35182793; rs12141867; rs12075735; rs12722974; rs1253482; rs12022958; rs34008190; rs10628782; rs12737642; rs6676236; rs34347193; rs12072318; rs12059454; rs12119997; rs12125531; rs12401583; rs1152993; rs35187698; rs4655228; rs34809737; rs6679821; rs35806956; rs12039573; rs34822300; rs1253481; rs12024909; rs6657978; rs11272233; rs11579996; rs35088359; rs34840123; rs34904959; rs818206; rs12120392; rs35234793; rs34988653; rs6688783; rs41467355; rs12740823; rs11591189; rs9970233; rs6665553; rs35285740; rs1689925; rs34995697; rs12143372; rs28591485; rs34722632; rs11334996; rs3072072; rs9970226; rs12029033; rs35351279; rs12731069; rs11580211; rs28743049; rs12752560; rs692943; rs12123445; rs12135846; rs34901070; rs35637551; rs35770611; rs34861922; rs5772908; rs34862360; rs7531198; rs12092374; rs4259612; rs1689926; rs12744559; rs12737656; rs34715988; rs4655227; rs34918162; rs34185271; rs12045976; rs10916823; rs12240109; rs12726436; rs476790; rs12117048; rs33942385; rs10601038; rs12095662; rs10711308; rs12128671; rs10753504; rs10916836; rs10916837; rs1572487; rs1614627; rs1689916; rs1781457; rs485716; rs485833; rs540282; rs586422; rs650264; rs652536; rs6687370; rs6695655; rs678980; rs680748

# Metabolic_Enzyme_2_General_References:
7923172; 9878810; 9596658; 8422236

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5317

# Metabolic_Enzyme_3_Name:
Thymidine kinase, cytosolic

# Metabolic_Enzyme_3_Synonyms:
Not Available

# Metabolic_Enzyme_3_Gene_Name:
TK1

# Metabolic_Enzyme_3_Protein_Sequence:
>Thymidine kinase, cytosolic
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTR
YSSSFCTHDR
NTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTV
IVAALDGTFQRKPFGAILNLV
PLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGA
DKYHSVCRLCYFKKASGQPAGPDNKENCPVPG
KPGEAVAARKLFAPQQILQCSPAN

# Metabolic_Enzyme_3_Number_of_Residues:
234

# Metabolic_Enzyme_3_Molecular_Weight:
25469

# Metabolic_Enzyme_3_Theoretical_pI:
8.61

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleoside kinase activity
Function:  deoxynucleoside kinase activity
Function:  thymidine kinase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
ATP + thymidine = ADP + thymidine 5'- phosphate

# Metabolic_Enzyme_3_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_3_Reaction:
ATP + thymidine = ADP + thymidine 5'-phosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00265:TK

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.7.1.21

# Metabolic_Enzyme_3_GenBank_ID_Protein:
339709

# Metabolic_Enzyme_3_SwissProt_ID:
KITH_HUMAN (P04183)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
TK1

# Metabolic_Enzyme_3_Geneatlas_id:
TK1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:11830

# Metabolic_Enzyme_3_PDB_ID:
1XBT

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>705 bp

ATGAGCTGCATTAACCTGCCCACTGTGCTGCCCGGCTCCCCCAGCAAGACCCGGGGGCA
GATCCAGGTGA
TTCTCGGGCCGATGTTCTCAGGAAAAAGCACAGAGTTGATGAGACGCG
TCCGTCGCTTCCAGATTGCTCA
GTACAAGTGCCTGGTGATCAAGTATGCCAAAGACACT
CGCTACAGCAGCAGCTTCTGCACACATGACCGG
AACACCATGGAGGCGCTGCCCGCCTG
CCTGCTCCGAGACGTGGCCCAGGAGGCCCTGGGCGTGGCTGTCA
TAGGCATCGACGAGG
GGCAGTTTTTCCCTGACATCATGGAGTTCTGCGAGGCCATGGCCAACGCCGGGAA
GACC
GTAATTGTGGCTGCACTGGATGGGACCTTCCAGAGGAAGCCATTTGGGGCCATCCTGAAC
CTGGTG
CCGCTGGCCGAGAGCGTGGTGAAGCTGACGGCGGTGTGCATGGAGTGCTTCCG
GGAAGCCGCCTATACCA
AGAGGCTCGGCACAGAGAAGGAGGTCGAGGTGATTGGGGGAG
CAGACAAGTACCACTCCGTGTGTCGGCT
CTGCTACTTCAAGAAGGCCTCAGGCCAGCCT
GCCGGGCCGGACAACAAAGAGAACTGCCCAGTGCCAGGA
AAGCCAGGGGAAGCCGTGGC
TGCCAGGAAGCTCTTTGCCCCACAGCAGATTCTGCAATGCAGCCCTGCCA
ACTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
K02581

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_3_Locus:
17q23.2-q25.3

# Metabolic_Enzyme_3_SNPs:
rs1143697; rs35330043; rs1065767; rs1065769; rs1065768; rs11653181; rs7217417; rs9897269; rs2854704; rs2854701; rs12452081; rs2854702; rs2661679; rs2006130; rs7217042; rs1811086; rs762542; rs735170; rs8072887; rs12601427; rs2515693; rs16970907; rs762541; rs9915560; rs11657629; rs9893988; rs4306580; rs2661680; rs12453050; rs9894890; rs2661681; rs2010371; rs12232476; rs1132543; rs34529187; rs1052931; rs11869997; rs8081639; rs34860308; rs36059491; rs2854703; rs28736712; rs7214459; rs2613510; rs7213946; rs2661678; rs28489345; rs35952086; rs2661682; rs2613511; rs11657714; rs762543; rs34727843; rs9899622; rs35275137; rs12602793; rs9896067; rs1071664; rs1079170; rs1109807; rs1109808; rs11654483; rs12449983; rs12450989; rs12936854; rs16970909; rs17640750; rs2292235; rs2467573; rs3794742; rs3794743; rs3829575; rs4465660; rs4789546; rs870355; rs906555; rs9891101; rs9897765; rs9899032; rs9902154; rs9903350

# Metabolic_Enzyme_3_General_References:
6549046; 3301530; 9575153

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5803

# Metabolic_Enzyme_4_Name:
Activation-induced cytidine deaminase

# Metabolic_Enzyme_4_Synonyms:
Cytidine aminohydrolase

# Metabolic_Enzyme_4_Gene_Name:
AICDA

# Metabolic_Enzyme_4_Protein_Sequence:
>Activationinduced cytidine deaminase
MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSLDFGYLRNKNGCHVELL
FLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTARLYFCEDRK
AEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFKAWEGLHENSVRLSRQLRRIL
LPLYEVDDLRDAFRTLGL

# Metabolic_Enzyme_4_Number_of_Residues:
198

# Metabolic_Enzyme_4_Molecular_Weight:
23954

# Metabolic_Enzyme_4_Theoretical_pI:
9.66

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses

# Metabolic_Enzyme_4_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_4_Reaction:
cytidine + H2O = uridine + ammonia

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF05240:APOBEC_C;
PF08210:APOBEC_N

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.5.4.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
9988410

# Metabolic_Enzyme_4_SwissProt_ID:
AICDA_HUMAN (Q9GZX7)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
AICDA

# Metabolic_Enzyme_4_Geneatlas_id:
AICDA

# Metabolic_Enzyme_4_hgnc_id:
HGNC:13203

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_4_Gene_Sequence:
>597 bp
ATGGACAGCCTCTTGATGAACCGGAGGAAGTTTCTTTACCAATTCAAAAATGTCCGCTGG
GCTAAGGGTCGGCGTGAGACCTACCTGTGCTACGTAGTGAAGAGGCGTGACAGTGCTACA
TCCTTTTCACTGGACTTTGGTTATCTTCGCAATAAGAACGGCTGCCACGTGGAATTGCTC
TTCCTCCGCTACATCTCGGACTGGGACCTAGACCCTGGCCGCTGCTACCGCGTCACCTGG
TTCACCTCCTGGAGCCCCTGCTACGACTGTGCCCGACATGTGGCCGACTTTCTGCGAGGG
AACCCCAACCTCAGTCTGAGGATCTTCACCGCGCGCCTCTACTTCTGTGAGGACCGCAAG
GCTGAGCCCGAGGGGCTGCGGCGGCTGCACCGCGCCGGGGTGCAAATAGCCATCATGACC
TTCAAAGATTATTTTTACTGCTGGAATACTTTTGTAGAAAACCATGAAAGAACTTTCAAA
GCCTGGGAAGGGCTGCATGAAAATTCAGTTCGTCTCTCCAGACAGCTTCGGCGCATCCTT
TTGCCCCTGTATGAGGTTGATGACTTACGAGACGCATTTCGTACTTTGGGACTTTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AB040431

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_4_Locus:
12p13

# Metabolic_Enzyme_4_SNPs:
rs2028373; rs12307097; rs11046349; rs7304723; rs2580874; rs2518144; rs2580873; rs1561560; rs2580875; rs12306110; rs1561559; rs2580876; rs3794318; rs17792729; rs1347978; rs3794316; rs1439868; rs2165191; rs3794317; rs11613792; rs1561562; rs1561561; rs714629; rs7316523; rs9971686; rs1561557; rs12297074; rs2019057; rs9971703; rs714630; rs3205190; rs10601618; rs34604633; rs11324989; rs7138990; rs35273657; rs10623739; rs12310085; rs28681214; rs11614281; rs5796316; rs1439869; rs12307620; rs34730872; rs12312451; rs5796317; rs33998240; rs35699718; rs1982214; rs12321976; rs34030304; rs1561558; rs1345004; rs9971705; rs28835914; rs12321209; rs12824576; rs2889653; rs7305961; rs7306108

# Metabolic_Enzyme_4_General_References:
10950930; 11007475; 11544457

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5804

# Metabolic_Enzyme_5_Name:
Uridine phosphorylase 2

# Metabolic_Enzyme_5_Synonyms:
UrdPase 2; UPase 2

# Metabolic_Enzyme_5_Gene_Name:
UPP2

# Metabolic_Enzyme_5_Protein_Sequence:
>Uridine phosphorylase 2
MASVIPASNRSMRSDRNTYVGKRFVHVKNPYLDLMDEDILYHLDLGTKTHNLPAMFGDVK
FVCVGGSPNRMKAFALFMHKELGFEEAEEDIKDICAGTDRYCMYKTGPVLAISHGMGIPS
ISIMLHELIKLLHHARCCDVTIIRIGTSGGIGIAPGTVVITDIAVDSFFKPRFEQVILDN
IVTRSTELDKELSEELFNCSKEIPNFPTLVGHTMCTYDFYEGQGRLDGALCSFSREKKLD
YLKRAFKAGVRNIEMESTVFAAMCGLCGLKAAVVCVTLLDRLDCDQINLPHDVLVEYQQR
PQLLISNFIRRRLGLCD

# Metabolic_Enzyme_5_Number_of_Residues:
317

# Metabolic_Enzyme_5_Molecular_Weight:
35528

# Metabolic_Enzyme_5_Theoretical_pI:
6.66

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
Function:  uridine phosphorylase activity
 ||
>>>
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide catabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_5_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates

# Metabolic_Enzyme_5_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_5_Reaction:
uridine + phosphate = uracil + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01048:PNP_UDP_1

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.4.2.3

# Metabolic_Enzyme_5_GenBank_ID_Protein:
32306848

# Metabolic_Enzyme_5_SwissProt_ID:
UPP2_HUMAN (O95045)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
UPP2

# Metabolic_Enzyme_5_Geneatlas_id:
UPP2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:23061

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Not Available

# Metabolic_Enzyme_5_Gene_Sequence:
>954 bp
ATGGCTTCAGTTATACCTGCCTCCAATAGGTCCATGAGATCTGACAGGAATACATATGTT
GGAAAAAGGTTTGTTCACGTTAAAAATCCTTACTTGGATTTGATGGATGAAGACATTCTC
TATCACTTGGATCTGGGAACAAAAACACACAACCTACCAGCAATGTTCGGAGATGTAAAG
TTCGTCTGTGTCGGTGGGAGCCCCAACAGAATGAAAGCATTTGCACTGTTTATGCACAAG
GAGCTCGGGTTTGAGGAAGCTGAAGAAGACATAAAAGACATCTGTGCTGGGACAGACAGA
TACTGTATGTACAAAACCGGGCCTGTGCTCGCCATCAGTCACGGCATGGGCATCCCCTCC
ATTTCTATTATGCTTCATGAACTCATCAAATTACTCCACCATGCACGGTGCTGCGATGTC
ACCATTATTAGAATCGGTACATCAGGGGGAATAGGGATGGCACCAGGACGTGTTGTAATA
ACGGATATAGCTGTAGACTCCTTCTTTAAGCCCCGGTTTGAACAGGTCATTTTGGACAAC
ATTGTCACCCGAAGTACTGAACTGGACAAAGAACTGTCTGAAGAACTGTTCAACTGTAGC
AAAGAAATCCCCAACTTCCCAACCCTCGTTGGACATACAATGTGTACCTATGATTTTTAT
GAAGGCCAAGGGCGACTAGATGGAGCACTGTGCTCCTTTTCCAGAGAAAAAAAGTTAGAC
TACTTGAAGAGAGCATTTAAAGCTGGTGTCAGGAATATTGAAATGGGAATCTACAGTGTT
TGCAGTATGTGTGGACTCTGTGGTCTAAAAGCTGCTGTGGTCTGTGTGACACTTCTCGAC
AGACTCGACTGTGATCAGATCAACTTGCCTCATGATGTCCTGGTGGAGTACCAGCAACGG
CCTCAGCTCCTAATCTCCAACTTCATCAGACGGCGGCTTGGACTTTGTGACTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AY225131

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_5_Locus:
2q24.1

# Metabolic_Enzyme_5_SNPs:
rs6710480; rs7561584; rs10186677; rs1160638; rs758279; rs1860164; rs765955; rs1860163; rs1860165; rs2098044; rs2190959; rs1329342; rs7593877; rs7591044; rs2159205; rs6437124; rs740553; rs10804388; rs7602989; rs4664918; rs7573932; rs4664922; rs6710348; rs2355162; rs1160637; rs7608061; rs6437129; rs1410958; rs6747631; rs758278; rs7593795; rs6757689; rs4664238; rs6731028; rs10755053; rs6437128; rs11895999; rs6437125; rs2355163; rs6739192; rs12465358; rs6706559; rs4664920; rs10171627; rs6437126; rs6746349; rs10192905; rs758280; rs6710054; rs4664236; rs7560174; rs725448; rs6724825; rs2355164; rs4664240; rs7582575; rs6739665; rs10182269; rs13401601; rs10204779; rs7607379; rs6745721; rs2024127; rs6755190; rs6759860; rs10933455; rs16842547; rs6723729; rs6749356; rs17420138; rs7604678; rs7355662; rs10187183; rs16842512; rs13418261; rs714566; rs981727; rs6731503; rs1468522; rs11690619; rs6718722; rs10165794; rs13388942; rs11684639; rs7567537; rs740551; rs13388607; rs7557328; rs7566548; rs971008; rs2024128; rs10460441; rs7594090; rs12104561; rs2074954; rs16842385; rs7565931; rs13020547; rs17419998; rs7567609; rs13406519; rs6437131; rs981729; rs9678256; rs12465287; rs6437130; rs10211094; rs1160636; rs7575665; rs7571138; rs10933457; rs13413757; rs13398821; rs6742818; rs1080178; rs7570575; rs16842429; rs1080177; rs16841677; rs740552; rs7560277; rs11902596; rs7578519; rs2079656; rs9288704; rs7577260; rs6734235; rs7577191; rs7560781; rs6437127; rs6437132; rs13418476; rs10933458; rs2052031; rs13032622; rs17491995; rs1080176; rs6758681; rs2079657; rs16842426; rs768364; rs7603318; rs11676875; rs6731053; rs6759948; rs13409467; rs7424774; rs10195028; rs11691557; rs16842383; rs11684410; rs2215176; rs13420712; rs4664239; rs981728; rs16842594; rs16842499; rs16842434; rs6712771; rs12996955; rs10180447; rs13396285; rs2108816; rs13400332; rs13019560; rs6744349; rs7597068; rs10193154; rs12992208; rs11690352; rs1329340; rs16842466; rs16842508; rs1019104; rs6707195; rs13395880; rs10173292; rs11691556; rs11690279; rs4664921; rs13414112; rs11679887; rs13431709; rs16842523; rs13024527; rs13383975; rs12474160; rs13429651; rs16842633; rs6752906; rs6729821; rs13391604; rs13383727; rs7602627; rs2190953; rs16842411; rs6752601; rs4664919; rs7424761; rs7424394; rs10205037; rs13396135; rs7560997; rs13007683; rs11892606; rs4664237; rs10173376; rs7605276; rs10196394; rs13431782; rs12052397; rs1329341; rs16842593; rs16842387; rs13404592; rs6707197; rs17491974; rs10178987; rs12623742; rs988059; rs11695349; rs16842413; rs6728626; rs13023991; rs2355165; rs7599139; rs16842494; rs10204540; rs10202707; rs10204766; rs13410444; rs7591370; rs10176046; rs13023813; rs6437136; rs10174157; rs6713525; rs7576829; rs6707705; rs6437135; rs7606259; rs6437139; rs13419905; rs10933459; rs10804389; rs6760699; rs6734022; rs6755018; rs6437134; rs6437137; rs6437138; rs6437133; rs6713742; rs1263152; rs4485523; rs13406552; rs2074955; rs7606365; rs17603277; rs16842609; rs6730188; rs6733576; rs13418976; rs6709528; rs7574417; rs11894922; rs7574058; rs7585982; rs6756966; rs7609063; rs4319893; rs4664924; rs1468523; rs4637056; rs4485524; rs986501; rs7568477; rs7559298; rs10190321; rs4637061; rs10182253; rs10209610; rs13010795; rs10489993; rs7568468; rs34393954; rs6749648; rs10199024; rs10182289; rs13409464; rs13007885; rs10197249; rs12987618; rs7559218; rs16842619; rs11692274; rs12466382; rs7586185; rs13415348; rs10176676; rs7558513; rs10192781; rs7602749; rs6749740; rs7595641; rs10172773; rs6720259; rs10489992; rs12465565; rs6437140; rs3732279; rs7563995; rs35667202; rs10649233; rs13395543; rs11451567; rs34328148; rs2190957; rs33978782; rs11688272; rs10171334; rs35035189; rs34236762; rs34079541; rs10167313; rs35643988; rs34346859; rs13392641; rs10184749; rs28529746; rs34051841; rs7370027; rs3046335; rs10206347; rs34858406; rs13430174; rs13401709; rs10588032; rs2190958; rs11385969; rs35445098; rs12994444; rs35914373; rs10669271; rs13011897; rs11368509; rs6710159; rs5835683; rs34251600; rs13415506; rs7596946; rs34401967; rs34727822; rs35725448; rs35506673; rs28612352; rs28847726; rs6716505; rs13410993; rs11693714; rs35584797; rs34617636; rs34088413; rs12622871; rs10209457; rs5835685; rs5835687; rs917436; rs12104874; rs10933456; rs7564199; rs34660503; rs4402705; rs10183520; rs3046317; rs34398242; rs35486102; rs35194717; rs7605839; rs34212212; rs35697287; rs36024578; rs28874086; rs10206564; rs35076196; rs34323275; rs34892908; rs34631670; rs33934505; rs34193222; rs10183432; rs35202631; rs13415827; rs34454142; rs13412267; rs28599871; rs10460440; rs4588140; rs35076177; rs5835684; rs13416620; rs13416665; rs10175465; rs13427050; rs10183725; rs35468647; rs35140289; rs36053410; rs13413349; rs34442284; rs35633639; rs35460315; rs11323864; rs34935392; rs35591991; rs11413909; rs35312435; rs10167563; rs35417307; rs7589538; rs34648163; rs28833261; rs11693718; rs13012457; rs13389062; rs5835686; rs35104636; rs35977051; rs28829033; rs34706033; rs28807099; rs36109899; rs16842542; rs13418088; rs35517147; rs35055946; rs34680995; rs3038700; rs4402709; rs34589629; rs10175147; rs35389393; rs10186068; rs34157085; rs13427854; rs11395471; rs34853011; rs11416542; rs35914872; rs7596057; rs35868430; rs35112132; rs13395928; rs13019867; rs10208607; rs3046319; rs10617951; rs10185823; rs34270243; rs13019865; rs6759429; rs10563166; rs34853147; rs10672261; rs36004863; rs13011867; rs13404450; rs34807293; rs13384407; rs34506664; rs34692448; rs35597793; rs13027617; rs34095699; rs7577178; rs13000552; rs6705270; rs36044623; rs35688453; rs35587030; rs34181729; rs10207916; rs13395544; rs10591831; rs35951280; rs35509538; rs7371040; rs10171454; rs5835688; rs35311908; rs13387173; rs13411417; rs34804695; rs35155903; rs34608455; rs36027783; rs35346642; rs1158092; rs10164918; rs35690771; rs35475728; rs4664241; rs5835689; rs16842631; rs28592926; rs11461708; rs35086036; rs35927015; rs11329452; rs10182683; rs34366637; rs34301784; rs11313905; rs7568699; rs10211260; rs35312089; rs35894691; rs13001633; rs13426920; rs34012057; rs10211674; rs10189273; rs7561784; rs10178978; rs41472346; rs13418081; rs35824279; rs35351369; rs28660327; rs6705376; rs12478184; rs36062141; rs11426649; rs34432055; rs36024954; rs34281845; rs13001639; rs10174277; rs35407621; rs34516060; rs2286434; rs13024270; rs34045341; rs10625973; rs35684986; rs6705279; rs4300787; rs34293201; rs10164653; rs13426502; rs13391015; rs11399969; rs35471010; rs13019127; rs34989247; rs4664917; rs34946444; rs10933454; rs11676663; rs11685602; rs11892485; rs11901550; rs12467193; rs12475094; rs1263154; rs1269326; rs13006741; rs13401024; rs1357185; rs16842366; rs16842635; rs16842639; rs17603340; rs2007056; rs2108811; rs2190954; rs2190955; rs2215174; rs2215175; rs2685641; rs6437122; rs6714867; rs714190; rs717378; rs720159; rs731627; rs736671; rs7573998; rs7577248

# Metabolic_Enzyme_5_General_References:
12849978

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5315

# Metabolic_Enzyme_6_Name:
Thymidine kinase 2, mitochondrial precursor

# Metabolic_Enzyme_6_Synonyms:
Mt-TK

# Metabolic_Enzyme_6_Gene_Name:
TK2

# Metabolic_Enzyme_6_Protein_Sequence:
>Thymidine kinase 2, mitochondrial precursor
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIA
SGKTTCLEFF
SNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLD
RHTRPQVSSVRLMERSIHSAR
YIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDL
IVYLRTNPETCYQRLKKRCREEEKVIPLEYLE
AIHHLHEEWLIKGSLFPMAAPVLVIEA
DHHHMERMLELFEQNRDRILTPENRKHCP

# Metabolic_Enzyme_6_Number_of_Residues:
266

# Metabolic_Enzyme_6_Molecular_Weight:
31142

# Metabolic_Enzyme_6_Theoretical_pI:
8.58

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs

# Metabolic_Enzyme_6_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_6_Reaction:
ATP + thymidine = ADP + thymidine 5'-phosphate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF01712:dNK

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.7.1.21

# Metabolic_Enzyme_6_GenBank_ID_Protein:
1905969

# Metabolic_Enzyme_6_SwissProt_ID:
KITM_HUMAN (O00142)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
TK2

# Metabolic_Enzyme_6_Geneatlas_id:
TK2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:11831

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_6_Gene_Sequence:
>705 bp

ATGGGTGCGTTCTGCCAGCGTCCTAGCAGTGATAAAGAACAGGAAAAAGAGAAAAAATC
AGTGATCTGTG
TCGAGGGCAATATTGCAGGTGGGAAGACGACATGCCTGGAATTCTTCT
CCAACGCGACAGACGTCGAGGT
GTTAACGGAGCCTGTGTCCAAGTGGAGAAATGTCCGT
GGCCACAATCCTCTGGGCCTGATGTACCACGAT
GCCTCTCGCTGGGGTCTTACGCTACA
GACTTATGTGCAGCTCACCATGCTGGACAGGCATACTCGTCCTC
AGGTGTCATCTGTAC
GGTTGATGGAGAGGTCGATTCACAGCGCAAGATACATTTTTGTAGAAAACCTGTA
TAGA
AGTGGGAAGATGCCAGAAGTGGACTATGTAGTTCTGTCGGAATGGTTTGACTGGATCTTG
AGGAAC
ATGGACGTGTCTGTTGATTTGATAGTTTACCTTCGGACCAATCCTGAGACTTG
TTACCAGAGGTTAAAGA
AGAGATGCAGGGAAGAGGAGAAGGTCATTCCGCTGGAATACC
TGGAAGCAATTCACCATCTCCATGAGGA
GTGGCTCATCAAAGGCAGCCTTTTCCCCATG
GCAGCCCCTGTTCTGGTGATTGAGGCTGACCACCACATG
GAGAGGATGTTAGAACTCTT
TGAACAAAATCGGGATCGAATATTAACTCCAGAGAATCGGAAGCATTGCC
CATAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
U77088

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_6_Locus:
16q22-q23.1

# Metabolic_Enzyme_6_SNPs:
rs3743716; rs3743715; rs880530; rs3743712; rs28171; rs755717; rs13334391; rs11859474; rs7191420; rs3826160; rs10492904; rs8064139; rs9930226; rs8044223; rs4783639; rs13331952; rs12448325; rs2241618; rs1366213; rs4783654; rs4783655; rs12445633; rs3826161; rs9932597; rs16956600; rs2288399; rs9924426; rs662089; rs2303776; rs9924955; rs37176; rs4783646; rs9924301; rs12102747; rs2241619; rs3743714; rs2241620; rs13331838; rs16956603; rs7196467; rs11865664; rs16956605; rs12447515; rs755716; rs9927697; rs7201934; rs37175; rs3743713; rs16956609; rs9934461; rs3743711; rs34931863; rs10454065; rs35138698; rs9930576; rs34946221; rs34364005; rs34974830; rs11378667; rs4441262; rs4783563; rs5817591; rs4783635; rs36122550; rs7191325; rs12928320; rs34922912; rs984375; rs5817593; rs4783643; rs4783628; rs34611947; rs35796755; rs397690; rs41377345; rs4783645; rs8047367; rs7189418; rs34482717; rs7498573; rs34207747; rs9673833; rs35291905; rs13339200; rs5817592; rs7201353; rs28626568; rs10709269; rs28667656; rs4783617; rs28454745; rs34214117; rs11643785; rs34613947; rs1346481; rs11383723; rs13338614; rs11334281; rs34906745; rs34484474; rs37177; rs35473118; rs384261; rs36049416; rs1108281; rs12444469; rs12449200; rs13333315; rs1428106; rs16956627; rs16956693; rs2002907; rs2232722; rs2232724; rs2232725; rs37178; rs3785086; rs3785087; rs3785088; rs4783659; rs7199632; rs725131; rs7498942; rs8054664; rs8058090; rs9796829; rs9933115

# Metabolic_Enzyme_6_General_References:
9079672; 9989599; 11687801; 12391347

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5805

# Metabolic_Enzyme_7_Name:
Purine nucleoside phosphorylase

# Metabolic_Enzyme_7_Synonyms:
Inosine phosphorylase; PNP

# Metabolic_Enzyme_7_Gene_Name:
NP

# Metabolic_Enzyme_7_Protein_Sequence:
>Purine nucleoside phosphorylase
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS

# Metabolic_Enzyme_7_Number_of_Residues:
289

# Metabolic_Enzyme_7_Molecular_Weight:
32118

# Metabolic_Enzyme_7_Theoretical_pI:
6.95

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  purine-nucleoside phosphorylase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_7_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_7_Reaction:
purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00896:Mtap_PNP

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.4.2.1

# Metabolic_Enzyme_7_GenBank_ID_Protein:
35565

# Metabolic_Enzyme_7_SwissProt_ID:
PNPH_HUMAN (P00491)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
NP

# Metabolic_Enzyme_7_Geneatlas_id:
NP

# Metabolic_Enzyme_7_hgnc_id:
HGNC:7892

# Metabolic_Enzyme_7_PDB_ID:
1RT9

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>870 bp
ATGGAGAACGGATACACCTATGAAGATTATAAGAACACTGCAGAATGGCTTCTGTCTCAT
ACTAAGCACCGACCTCAAGTTGCAATAATCTGTGGTTCTGGATTAGGAGGTCTGACTGAT
AAATTAACTCAGGCCCAGATCTTTGACTACAGTGAAATCCCCAACTTTCCTCGAAGTACA
GTGCCAGGTCATGCTGGCCGACTGGTGTTTGGGTTCCTGAATGGCAGGGCCTGTGTGATG
ATGCAGGGCAGGTTCCACATGTATGAAGGGTACCCACTCTGGAAGGTGACATTCCCAGTG
AGGGTTTTCCACCTTCTGGGTGTGGACACCCTGGTAGTCACCAATGCAGCAGGAGGGCTG
AACCCCAAGTTTGAGGTTGGAGATATCATGCTGATCCGTGACCATATCAACCTACCTGGT
TTCAGTGGTCAGAACCCTCTCAGAGGGCCCAATGATGAAAGGTTTGGAGATCGTTTCCCT
GCCATGTCTGATGCCTACGACCGGACTATGAGGCAGAGGGCTCTCAGTACCTGGAAACAA
ATGGGGGAGCAACGTGAGCTACAGGAAGGCACCTATGTGATGGTGGCAGGCCCCAGCTTT
GAGACTGTGGCAGAATGTCGTGTGCTGCAGAAGCTGGGAGCAGACGCTGTTGGCATGAGT
ACAGTACCAGAAGTTATCGTTGCACGGCACTGTGGACTTCGAGTCTTTGGCTTCTCACTC
ATCACTAACAAGGTCATCATGGATTATGAAAGCCTGGAGAAGGCCAACCATGAAGAAGTC
TTAGCAGCTGGCAAACAAGCTGCACAGAAATTGGAACAGTTTGTCTCCATTCTTATGGCC
AGCATTCCACTCCCTGACAAAGCCAGTTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
X00737

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_7_Locus:
14q13.1

# Metabolic_Enzyme_7_SNPs:
rs1049564; rs1130650; rs1049562; rs7785; rs1617940; rs1760940; rs1713420; rs1760935; rs1713422; rs1713421; rs3790064; rs3790065; rs1713429; rs17882804; rs17880405; rs1756369; rs12147688; rs8008133; rs17881431; rs17881345; rs7154909; rs17883821; rs17885781; rs1760934; rs17879107; rs17880844; rs17879913; rs17881184; rs17885714; rs17880480; rs17883253; rs17878900; rs1713426; rs17881356; rs1713427; rs1760933; rs3790062; rs17883795; rs17112168; rs17880290; rs12147906; rs17881554; rs17881206; rs1049700; rs17882836; rs12101049; rs17884106; rs12147035; rs34480769; rs3838361; rs3842517; rs1760939; rs17885917; rs17886095; rs1760938; rs17883294; rs17883604; rs8019880; rs17881280; rs35549071; rs35139440; rs17880503; rs7151666; rs10498268; rs1079375; rs1079376; rs11846743; rs11850059; rs11850069; rs12587218; rs12886203; rs12888804; rs12891271; rs13379232; rs13379234; rs1629478; rs17112384; rs17112385; rs1713459; rs1713460; rs1713461; rs1713462; rs17242655; rs17242662; rs17242669; rs1756365; rs1760930; rs1760931; rs1760941; rs1760942; rs2077153; rs2481768; rs35175606; rs35567022; rs7156659; rs755777

# Metabolic_Enzyme_7_General_References:
6087295; 3029074; 12928150; 2104852; 1384322; 8931706

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5806

# Metabolic_Enzyme_8_Name:
Thymidine phosphorylase precursor

# Metabolic_Enzyme_8_Synonyms:
TdRPase; TP; Platelet-derived endothelial cell growth factor; PD-ECGF; Gliostatin

# Metabolic_Enzyme_8_Gene_Name:
ECGF1

# Metabolic_Enzyme_8_Protein_Sequence:
>Thymidine phosphorylase precursor
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ

# Metabolic_Enzyme_8_Number_of_Residues:
482

# Metabolic_Enzyme_8_Molecular_Weight:
49956

# Metabolic_Enzyme_8_Theoretical_pI:
5.19

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  pyrimidine base metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis

# Metabolic_Enzyme_8_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_8_Reaction:
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF02885:Glycos_trans_3N;
PF00591:Glycos_transf_3;
PF07831:PYNP_C

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.4.2.4

# Metabolic_Enzyme_8_GenBank_ID_Protein:
189701

# Metabolic_Enzyme_8_SwissProt_ID:
TYPH_HUMAN (P19971)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
ECGF1

# Metabolic_Enzyme_8_Geneatlas_id:
ECGF1

# Metabolic_Enzyme_8_hgnc_id:
HGNC:3148

# Metabolic_Enzyme_8_PDB_ID:
1UOU

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Not Available

# Metabolic_Enzyme_8_Gene_Sequence:
>1449 bp
ATGGCAGCCTTGATGACCCCGGGAACCGGGGCCCCACCCGCGCCTGGTGACTTCTCCGGG
GAAGGGAGCCAGGGACTTCCCGACCCTTCGCCAGAGCCCAAGCAGCTCCCGGAGCTGATC
CGCATGAAGCGAGACGGAGGCCGCCTGAGCGAAGCGGACATCAGGGGCTTCGTGGCCGCT
GTGGTGAATGGGAGCGCGCAGGGCGCACAGATCGGGGCCATGCTGATGGCCATCCGACTT
CGGGGCATGGATCTGGAGGAGACCTCGGTGCTGACCCAGGCCCTGGCTCAGTCGGGACAG
CAGCTGGAGTGGCCAGAGGCCTGGCGCCAGCAGCTTGTGGACAAGCATTCCACAGGGGGT
GTGGGTGACAAGGTCAGCCTGGTCCTCGCACCTGCCCTGGCGGCATGTGGCTGCAAGGTG
CCAATGATCAGCGGACGTGGTCTGGGGCACACAGGAGGCACCTTGGATAAGCTGGAGTCT
ATTCCTGGATTCAATGTCATCCAGAGCCCAGAGCAGATGCAAGTGCTGCTGGACCAGGCG
GGCTGCTGTATCGTGGGTCAGAGTGAGCAGCTGGTTCCTGCGGACGGAATCCTATATGCA
GCCAGAGATGTGACAGCCACCGTGGACAGCCTGCCACTCATCACAGCCTCCATTCTCAGT
AAGAAACTCGTGGAGGGGCTGTCCGCTCTGGTGGTGGACGTTAAGTTCGGAGGGGCCGCC
GTCTTCCCCAACCAGGAGCAGGCCCGGGAGCTGGCAAAGACGCTGGTTGGCGTGGGAGCC
AGCCTAGGGCTTCGGGTCGCGGCAGCGCTGACCGCCATGGACAAGCCCCTGGGTCGCTGC
GTGGGCCACGCCCTGGAGGTGGAGGAGGCGCTGCTCTGCATGGACGGCGCAGGCCCGCCA
GACTTAAGGGACCTGGTCACCACGCTCGGGGGCGCCCTGCTCTGGCTCAGCGGACACGCG
GGGACTCAGGCTCAGGGCGCTGCCCGGGTGGCCGCGGCGCTGGACGACGGCTCGGCCCTT
GGCCGCTTCGAGCGGATGCTGGCGGCGCAGGGCGTGGATCCCGGTCTGGCCCGAGCCCTG
TGCTCGGGAAGTCCCGCAGAACGCCGGCAGCTGCTGCCTCGCGCCCGGGAGCAGGAGGAG
CTGCTGGCGCCCGCAGATGGCACCGTGGAGCTGGTCCGGGCGCTGCCGCTGGCGCTGGTG
CTGCACGAGCTCGGGGCCGGGCGCAGCCGCGCTGGGGAGCCGCTCCGCCTGGGGGTGGGC
GCAGAGCTGCTGGTCGACGTGGGTCAGAGGCTGCGCCGTGGGACCCCCTGGCTCCGCGTG
CACCGGGACGGCCCCGCGCTCAGCGGCCCGCAGAGCCGCGCCCTGCAGGAGGCGCTCGTA
CTCTCCGACCGCGCGCCATTCGCCGCCCCCTCGCCCTTCGCAGAGCTCGTTCTGCCGCCG
CAGCAATAA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
M63193

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_8_Locus:
22q13|22q13.33

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
2467210; 1570012; 1400349; 1590793; 9924029; 12177387

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5316

# Metabolic_Enzyme_9_Name:
Thymidylate synthase

# Metabolic_Enzyme_9_Synonyms:
TS; TSase

# Metabolic_Enzyme_9_Gene_Name:
TYMS

# Metabolic_Enzyme_9_Protein_Sequence:
>Thymidylate synthase
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDE
FPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLD
SLGFSTREEGDLGPVYGFQWR
HFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRII
MCAWNPRDLPLMALPPCHALCQFYVVNSELSC
QLYQRSGDMGLGVPFNIASYALLTYMI
AHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLR
ILRKVEKIDDFKAEDF
QIEGYNPHPTIKMEMAV

# Metabolic_Enzyme_9_Number_of_Residues:
313

# Metabolic_Enzyme_9_Molecular_Weight:
35716

# Metabolic_Enzyme_9_Theoretical_pI:
7.00

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  5,10-methylenetetrahydrofolate-dependent methyltransferase activity
Function:  thymidylate synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  pyrimidine nucleotide metabolism
Process:  pyrimidine nucleotide biosynthesis
Process:  pyrimidine nucleoside monophosphate biosynthesis
Process:  pyrimidine deoxyribonucleoside monophosphate biosynthesis
Process:  dTMP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP

# Metabolic_Enzyme_9_Pathway:
map00240  Pyrimidine metabolism;
 map00670  One carbon pool by folate

# Metabolic_Enzyme_9_Reaction:
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00303:Thymidylat_synt

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.1.1.45

# Metabolic_Enzyme_9_GenBank_ID_Protein:
37479

# Metabolic_Enzyme_9_SwissProt_ID:
TYSY_HUMAN (P04818)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
TYMS

# Metabolic_Enzyme_9_Geneatlas_id:
TYMS

# Metabolic_Enzyme_9_hgnc_id:
HGNC:12441

# Metabolic_Enzyme_9_PDB_ID:
1JUJ

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Not Available

# Metabolic_Enzyme_9_Gene_Sequence:
>942 bp

ATGCCTGTGGCCGGCTCGGAGCTGCCGCGCCGGCCCTTGCCCCCCGCCGCACAGGAGCG
GGACGCCGAGC
CGCGTCCGCCGCACGGGGAGCTGCAGTACCTGGGGCAGATCCAACACA
TCCTCCGCTGCGGCGTCAGGAA
GGACGACCGCACGGGCACCGGCACCCTGTCGGTATTC
GGCATGCAGGCGCGCTACAGCCTGAGAGATGAA
TTCCCTCTGCTGACAACCAAACGTGT
GTTCTGGAAGGGTGTTTTGGAGGAGTTGCTGTGGTTTATCAAGG
GATCCACAAATGCTA
AAGAGCTGTCTTCCAAGGGAGTGAAAATCTGGGATGCCAATGGATCCCGAGACTT
TTTG
GACAGCCTGGGATTCTCCACCAGAGAAGAAGGGGACTTGGGCCCAGTTTATGGCTTCCAG
TGGAGG
CATTTTGGGGCAGAATACAGAGATATGGAATCAGATTATTCAGGACAGGGAGT
TGACCAACTGCAAAGAG
TGATTGACACCATCAAAACCAACCCTGACGACAGAAGAATCA
TCATGTGCGCTTGGAATCCAAGAGATCT
TCCTCTGATGGCGCTGCCTCCATGCCATGCC
CTCTGCCAGTTCTATGTGGTGAACAGTGAGCTGTCCTGC
CAGCTGTACCAGAGATCGGG
AGACATGGGCCTCGGTGTGCCTTTCAACATCGCCAGCTACGCCCTGCTCA
CGTACATGA
TTGCGCACATCACGGGCCTGAAGCCAGGTGACTTTATACACACTTTGGGAGATGCACATA
T
TTACCTGAATCACATCGAGCCACTGAAAATTCAGCTTCAGCGAGAACCCAGACCTTTC
CCAAAGCTCAGG
ATTCTTCGAAAAGTTGAGAAAATTGATGACTTCAAAGCTGAAGACTT
TCAGATTGAAGGGTACAATCCGC
ATCCAACTATTAAAATGGAAATGGCTGTTTAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
X02308

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:18

# Metabolic_Enzyme_9_Locus:
18p11.32

# Metabolic_Enzyme_9_SNPs:
rs3786362; rs16948421; rs699517; rs16948409; rs2790; rs2612098; rs2853740; rs2612100; rs1001761; rs2847149; rs2853532; rs2853536; rs2244500; rs2612099; rs2853543; rs11873890; rs1004474; rs2612096; rs1059394; rs16948305; rs9953447; rs2847609; rs2847150; rs1051527; rs8088781; rs2612095; rs1059393; rs3826626; rs15872; rs2853524; rs2853537; rs16948322; rs34795969; rs2847151; rs1970763; rs2853528; rs2853535; rs2606245; rs2853525; rs2853534; rs2847153; rs35143366; rs11876369; rs2853526; rs8094124; rs35069638; rs2925470; rs2015944; rs2853527; rs36005458; rs35517586; rs35449827; rs35710611; rs36080427; rs34502878; rs34007153; rs523998; rs11540152; rs596909; rs11540153; rs2847608; rs34543484; rs287599; rs571276; rs188267; rs1134333; rs2853531; rs11872109; rs172296; rs2853540; rs2853541; rs34118802; rs11875638; rs287600; rs2124616; rs2853530; rs11872105; rs35087169; rs9675762; rs1134338; rs12958458; rs11875614; rs2853739; rs35914751; rs287601; rs1894234; rs35626549; rs2853538; rs1894233; rs12962403; rs287602; rs1672564; rs1134335; rs35338895; rs2606244; rs8093444; rs2847610; rs35723992; rs207950; rs11878085; rs36009852; rs2853529; rs28503425; rs12326481; rs34581442; rs207949; rs571377; rs8084452; rs35623440; rs34941278; rs1672569; rs2606243; rs2606242; rs644072; rs2926562; rs2847611; rs11874511; rs11411741; rs11875662; rs10502289; rs10502290; rs1058151; rs1059384; rs11081251; rs11081266; rs11664283; rs11873007; rs11876755; rs11877806; rs12373391; rs12964837; rs2276115; rs2298581; rs2298582; rs2298583; rs2606241; rs2606246; rs2612092; rs2741182; rs2741183; rs2741184; rs2741186; rs2847173; rs2847324; rs2847326; rs2847607; rs2847612; rs2847620; rs2853533; rs2853741; rs2853742; rs3198762; rs34445332; rs35173059; rs3744962; rs3786355; rs3819101; rs3819102; rs495139; rs502396; rs539913; rs548203; rs579099; rs686819; rs7229142; rs7239738; rs8089075; rs8423; rs9948583; rs9966612

# Metabolic_Enzyme_9_General_References:
2987839; 2243092; 2532645; 3839505; 2656695; 8845352; 11329255; 11278511

# Metabolic_Enzyme_9_References:
11984070; 12853888; 12903197; 17150837

# Metabolic_Enzyme_10_ID:
7434

# Metabolic_Enzyme_10_Name:
Caspase-3 precursor

# Metabolic_Enzyme_10_Synonyms:
CASP-3; Apopain; Cysteine protease CPP32; Yama protein; CPP-32; SREBP cleavage activity 1; SCA-1[Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]

# Metabolic_Enzyme_10_Gene_Name:
CASP3

# Metabolic_Enzyme_10_Protein_Sequence:
>Caspase3 precursor
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

# Metabolic_Enzyme_10_Number_of_Residues:
277

# Metabolic_Enzyme_10_Molecular_Weight:
31608

# Metabolic_Enzyme_10_Theoretical_pI:
6.51

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  cysteine-type endopeptidase activity
Function:  caspase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Not Available

# Metabolic_Enzyme_10_Specific_Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin

# Metabolic_Enzyme_10_Pathway:
Not Available

# Metabolic_Enzyme_10_Reaction:
Not Available

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00656:Peptidase_C14

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 3.4.22.56

# Metabolic_Enzyme_10_GenBank_ID_Protein:
561666

# Metabolic_Enzyme_10_SwissProt_ID:
CASP3_HUMAN (P42574)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
CASP3

# Metabolic_Enzyme_10_Geneatlas_id:
CASP3

# Metabolic_Enzyme_10_hgnc_id:
HGNC:1504

# Metabolic_Enzyme_10_PDB_ID:
1CP3

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_10_Gene_Sequence:
>834 bp
ATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATC
ATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGAT
TATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGA
ATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAAC
TTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATG
CGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGC
CATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACA
AACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATT
CAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGAT
GACATGGCGTGTCATAAAATACCAGTGGATGCCGACTTCTTGTATGCATACTCCACAGCA
CCTGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGT
GCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAAC
CGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAA
CAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
U13737

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_10_Locus:
4q34

# Metabolic_Enzyme_10_SNPs:
rs35578277; rs1049210; rs35566035; rs1049253; rs2720378; rs3087455; rs6948; rs4647640; rs4647610; rs4647617; rs4647642; rs4647634; rs4647611; rs4647620; rs1049216; rs4647641; rs4647618; rs4647609; rs4647694; rs8549; rs4647698; rs4647614; rs4647621; rs4647622; rs4647616; rs4647633; rs4647643; rs4647630; rs34184817; rs4647647; rs35422505; rs4647624; rs4647626; rs4647696; rs4647606; rs4647631; rs4647646; rs4647607; rs4647625; rs34022730; rs35439719; rs2720377; rs4647632; rs4647628; rs2310103; rs34309992; rs4647629; rs4647644; rs4647636; rs2019978; rs2705891; rs1830254; rs2720376; rs2696056; rs4241793; rs4647667; rs4647688; rs4647663; rs1405942; rs4647652; rs1405938; rs4647662; rs2705901; rs1405944; rs4647671; rs4647665; rs2696057; rs4647693; rs4647672; rs2705897; rs4647669; rs4647673; rs4647692; rs4647674; rs4647666; rs4647686; rs4647683; rs4647690; rs4647657; rs4987118; rs4647679; rs4647670; rs4987119; rs4647658; rs4647684; rs4647675; rs4647650; rs34319440; rs4647685; rs2696048; rs4647651; rs4647676; rs4647687; rs4647655; rs13128316; rs13435139; rs4647704; rs4647700; rs12646257; rs4647701; rs4647623; rs4647635; rs10028033; rs12641602; rs13101834; rs11380373; rs4647695; rs34119644; rs2705892; rs34858791; rs35063555; rs4647699; rs4647639; rs34095700; rs4647619; rs13102911; rs4647645; rs4647612; rs13101835; rs4647637; rs4647638; rs2705893; rs4647649; rs2696060; rs10028034; rs4647697; rs4647613; rs35978407; rs4647608; rs4647615; rs28418774; rs4647648; rs1802667; rs34568867; rs7442206; rs4647682; rs4647656; rs4647681; rs4647668; rs4647677; rs4647678; rs4647691; rs35261594; rs4647689; rs4647653; rs35966919; rs34740772; rs4647659; rs41314884; rs9997231; rs3215361; rs4647661; rs4647654; rs10014306; rs10660141; rs4647664; rs4647660; rs4647680; rs10034836; rs35094553; rs9715122; rs4647705; rs34083547; rs9715863; rs4647702; rs4647703; rs11930666; rs12108497; rs12507711; rs13108061; rs13435890; rs1405937; rs2696058; rs2696059; rs2705881; rs2705882; rs2705900; rs2720388; rs2720389; rs34605630; rs4647600; rs4647602; rs4647603; rs4647605; rs4861629; rs4862396; rs4862399; rs7673753; rs7674164; rs7687648; rs9685847

# Metabolic_Enzyme_10_General_References:
7983002; 7774019; 7596430; 8673606; 9045680; 10821855; 8755496; 8696339

# Metabolic_Enzyme_10_References:
15178742; 15819958; 16772436

End of HMDB00012

Beginning of HMDB00014
# Accession_No:
HMDB00014

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-02-01 13:45:39

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Deoxycytidine

# Description:
One of the principal nucleosides of DNA composed of cytosine and deoxyribose. A nucleoside consists of only a pentose sugar linked to a purine or pyrimidine base, without a phosphate group. When N1 is linked to the C1 of deoxyribose, deoxynucleosides and nucleotides are formed from cytosine and deoxyribose; deoxycytidine monophosphate (dCMP), deoxycytidine diphosphate (dCDP), deoxycytidine triphosphate (dCTP). CTP is the source of the cytidine in RNA (ribonucleic acid) and deoxycytidine triphosphate (dCTP) is the source of the deoxycytidine in DNA (deoxyribonucleic acid).

# Synonyms:
1-(2-Deoxy-b-D-ribofuranosyl)cytosine; 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-Cytosine; 2'-Deoxycytidine; 2-deoxy-Cytidine; 4-Amino-1-(2-deoxy-b-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone; Cytosine deoxyribonucleoside; Cytosine deoxyriboside; Deoxyribose cytidine; Desoxycytidine; deoxy-Cytidine; 1-(2-Deoxy-beta-delta-ribofuranosyl)cytosine; 1-(2-deoxy-beta-delta-erythro-pentofuranosyl)-Cytosine; 4-Amino-1-(2-deoxy-beta-delta-erythro-pentofuranosyl)-2(1H)-pyrimidinone; 1-(2-Deoxy-beta-D-ribofuranosyl)cytosine; 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone

# Chemical_IUPAC_Name:
4-amino-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-pyrimidin-2-one

# Chemical_Formula:
C9H13N3O4

# Chemical_Structure:
tbl_chemical:::HMDB00014_ZOOM.png:::119283127102832366

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00014_THUMB.png:::119283126899324538

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines; Nucleosides

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; primary alcohol; secondary alcohol; primary amine; primary aromatic amine; oxo(het)arene; urea; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of Purine metabolism; Component of Pyrimidine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
227.09061

# Molecular_Weight_Avg:
227.21722

# Smiles_String_isomeric:
NC1=NC(=O)N(C=C1)[C@H]2C[C@H](O)[C@@H](CO)O2

# Smiles_String_canonical:
NC1=NC(=O)N(C=C1)C2CC(O)C(CO)O2

# KEGG_Compound_ID:
C00881

# BioCyc_ID:
DEOXYCYTIDINE

# PubChem_CID:
13711

# PubChem_SID:
829250; 10317412; 12016225; 829248; 585295; 7886940; 157047; 8160334; 841405; 596443; 726441; 823291; 10317409; 4137

# OMIM_ID:
164050; 176270; 232700

# Metagene_ID:
Not Available

# BiGG_ID:
36280

# Wikipedia_ID:
Deoxycytidine

# METLIN_ID:
3367

# Ref_ID:
15203276; 15116424; Maley, F. et al., J. Biol. Chem., 1958, 233, 1538-1543, (5-diphosphate); Charubala, R. et al., Synthesis, 1984, 965-968, (5'-(4,4'-dimethoxytrityl) 4N-benzoyl); Schaller, H. et al., J.A.C.S., 1963, 85, 3821-3827, (5'-(4,4'-dimethoxytrityl) 4N-benzoyl); Benz, E. et al., J.O.C., 1965, 30, 3067-3071, (4N-benzoyl, 5'-tosyl, 3',4N-dibenzoyl, 4N,5'-dibenzoyl, 5'-tosyl 4N-benzoyl, 5'-trityl 3',4N-dibenzoyl); Hruska, F.E. et al., Can. J. Chem., 1974, 52, 497-508, (pmr); 6714272; Jones, A.J. et al., Proc. Natl. Acad. Sci. U.S.A., 1970, 65, 27-30, CA, 72, 96682j, (cmr); Miles, H.T., J.A.C.S., 1963, 85, 1007-1008, (ir, pmr); Young, D.W. et al., Acta Cryst. B, 1975, 31, 961-965, (cryst struct); 12171902; Michelson, A.M. et al., J.C.S., 1954, 34-40, (phosphates, 3',4N-di-Ac, 5'-trityl, 5'-trityl 3',4N-di-Ac); Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, DAQ850; Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 396A, 396C, (nmr); Stawinski, J. et al., Chem. Comm., 1976, 243-244, (3',4N,5'-tribenzoyl); Ulbricht, T.L.V. et al., J.C.S., 1965, 6134-6135, (3N-Me); Wang, Z. et al., J.O.C., 2000, 65, 5969-5985, (synth, ir, pmr, cmr); Saneyoshi, M. et al., Nucleic Acids Res., 1981, 9, 3129-3138, (5'-triphosphate, synth, uv, biochem); Fox, J.J. et al., Adv. Carbohydr. Chem., 1959, 14, 283-380, (rev, derivs); Saladino, R. et al., Tetrahedron, 1996, 52, 6759-6780, (4N-Me, 4N-Et, 4N-(4-methylphenyl), synth, pmr, cmr); Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 832B, 838D, 839C, (ir); 3243806; Yang, J.T. et al., CA, 1966, 65, 12454, (ord)

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
951-77-9

# InChI:
InChI=1/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1

# Synthesis_Reference:
Saneyoshi, M. et al., Nucleic Acids Res., 1981, 9, 3129-3138; Saneyoshi, M. et al., Nucleic Acids Res., 1981, 9, 3129-3138; Saladino, R. et al., Tetrahedron, 1996, 52, 6759-6780; Wang, Z. et al., J.O.C., 2000, 65, 5969-5985

# Melting_Point:
207-210 oC

# Melting_Point_predicted:
108.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
870 mg/mL [free base, HMP experimental]

# H2O_Solubility_Predicted:
63.4 mg/mL [MEYLAN,WM et al. (1996)]; 15.9 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-1.77 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-1.92 [Predicted by ALOGPS]; -1.9 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00881.mol:::1132723801156107349

# SDF_File_[Text]:
tbl_chemical:::HMDB00014.sdf:::119283126433212682

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00014.pdb:::119283126726122733

# PDB_ID:
1J90

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1J90.txt:::1132720898718427316

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041105_P00_04_HW_1DP_presat.png:::11551555101945511

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041105_P00_04_HW_1DP_presat.zip:::115515551020999995

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041105_P00_04_HW_1DP_Assigned.png:::115628031058063658

# C_NMR_Spectra:
tbl_cnmr:::041105_P00_04_HW_1DC_94.jpg:::114168459446033390

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041105_P00_04_HW_1DC_94.zip:::114168459443255687

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041105_P00_04_HW_1DC_94_Assigned.jpg:::115946433348387500

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041105_P00_04_HW_2DHSQC_339.jpg:::114608624892911228

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041105_P00_04_HW_2DHSQC_339.zip:::11460862490032504

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041105_P00_04_HW_2DHSQC_339_Assigned.jpg:::115946429593996119

# Predicted_H_NMR_Spectrum:
tbl_chemical:::2'-Deoxycytidine.gif:::1132732098828208828

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00014_peaks.txt:::1156309484160595268

# Predicted_C_NMR_Spectrum:
tbl_chemical:::2'-Deoxycytidine_C.gif:::1132737657297963376

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00014_peaks.txt:::1156310676184225629

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00014L.png:::117555261807188854; Medium Energy:tbl_ms:::HMDB00014M.png:::117555266921725073; High Energy:tbl_ms:::HMDB00014H.png:::117555270808365480

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP); Extracellular; lysosome; mitochondria; nucleus

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	0.65 +/- 0.27	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	15116424
Blood	< 0.5	uM	Adult:>18_yrs_old	Both	Normal	3243806


# Concentration_[Abnormal]:
Urine	0.27 +/- 0.193	umol/mmol_creatinine	Adult:>18_yrs_old	Both		15116424


# Associated_Disorders:
Not Available

# Pathway_Names:
Purine metabolism;Nicotinate and nicotinamide metabolism

# Pathway_Images:
Purine_Synthesis.jpg;Nicotinamide_synthesis_(NADH).jpg

# KEGG_Images:
map00230;map00760

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;Nicotinamide_synthesis_(NADH)_Graph.jpg

# Pathway_SBMLs:
Purine_Synthesis.xml;Nicotinamide_synthesis_(NADH).xml

# Metabolic_Enzyme_1_ID:
5235

# Metabolic_Enzyme_1_Name:
Deoxycytidine kinase

# Metabolic_Enzyme_1_Synonyms:
dCK

# Metabolic_Enzyme_1_Gene_Name:
DCK

# Metabolic_Enzyme_1_Protein_Sequence:
>Deoxycytidine kinase
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
DFKDKYESLVEKVKEFLSTL

# Metabolic_Enzyme_1_Number_of_Residues:
260

# Metabolic_Enzyme_1_Molecular_Weight:
30519

# Metabolic_Enzyme_1_Theoretical_pI:
4.88

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents

# Metabolic_Enzyme_1_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_1_Reaction:
NTP + deoxycytidine = NDP + dCMP

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01712:dNK

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.7.1.74

# Metabolic_Enzyme_1_GenBank_ID_Protein:
181510

# Metabolic_Enzyme_1_SwissProt_ID:
DCK_HUMAN (P27707)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
DCK

# Metabolic_Enzyme_1_Geneatlas_id:
DCK

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2704

# Metabolic_Enzyme_1_PDB_ID:
1P62

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_1_Gene_Sequence:
>783 bp
ATGGCCACCCCGCCCAAGAGAAGCTGCCCGTCTTTCTCAGCCAGCTCTGAGGGGACCCGC
ATCAAGAAAATCTCCATCGAAGGGAACATCGCTGCAGGGAAGTCAACATTTGTGAATATC
CTTAAACAATTGTGTGAAGATTGGGAAGTGGTTCCTGAACCTGTTGCCAGATGGTGCAAT
GTTCAAAGTACTCAAGATGAATTTGAGGAACTTACAATGTCTCAGAAAAATGGTGGGAAT
GTTCTTCAGATGATGTATGAGAAACCTGAACGATGGTCTTTTACCTTCCAAACATATGCC
TGTCTCAGTCGAATAAGAGCTCAGCTTGCCTCTCTGAATGGCAAGCTCAAAGATGCAGAG
AAACCTGTATTATTTTTTGAACGATCTGTGTATAGTGACAGGTATATTTTTGCATCTAAT
TTGTATGAATCTGAATGCATGAATGAGACAGAGTGGACAATTTATCAAGACTGGCATGAC
TGGATGAATAACCAATTTGGCCAAAGCCTTGAATTGGATGGAATCATTTATCTTCAAGCC
ACTCCAGAGACATGCTTACATAGAATATATTTACGGGGAAGAAATGAAGAGCAAGGCATT
CCTCTTGAATATTTAGAGAAGCTTCATTATAAACATGAAAGCTGGCTCCTGCATAGGACA
CTGAAAACCAACTTCGATTATCTTCAAGAGGTGCCTATCTTAACACTGGATGTTAATGAA
GACTTTAAAGACAAATATGAAAGTCTGGTTGAAAAGGTCAAAGAGTTTTTGAGTACTTTG
TGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M60527

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_1_Locus:
4q13.3-q21.1

# Metabolic_Enzyme_1_SNPs:
rs4643786; rs16845677; rs1385986; rs936868; rs936869; rs1486271; rs6446999; rs4694362; rs6446988; rs10518080; rs10805074; rs7684954; rs12648166; rs4235090; rs2010401; rs7669445; rs4490428; rs7439745; rs1552381; rs16845668; rs11935198; rs4308342; rs3775289; rs7672935; rs6819369; rs12513206; rs1580469; rs7699819; rs2171195; rs7684573; rs7697366; rs13106279; rs17686997; rs11728260; rs7691350; rs7690840; rs7659473; rs9993633; rs6841923; rs9997995; rs6446989; rs11731434; rs12513202; rs6446998; rs2035576; rs2129173; rs12501375; rs11737567; rs7672339; rs16845626; rs7659998; rs1385987; rs7693891; rs7672954; rs4694360; rs4525938; rs1906021; rs11544786; rs34662212; rs5859247; rs13124044; rs13124045; rs3065775; rs35686785; rs1803484; rs13124290; rs5859246; rs28734949; rs10019874; rs4021444; rs34857131; rs34482223; rs36018698; rs11394166; rs11935525; rs35461637; rs28867977; rs12503595; rs7656043; rs35177789; rs34193080; rs13117017; rs34109101; rs35278579; rs35147498; rs11460671; rs7699712; rs28404918; rs11337561; rs34139336; rs4694363; rs3833976; rs34969740; rs34676003; rs35858453; rs35754685; rs35688113; rs36078513; rs28545112; rs9997790; rs4597793; rs35755135; rs34078875; rs4377559; rs7698012; rs2363439; rs12511143; rs11728201; rs35880082; rs11315015; rs35477149; rs28715337; rs11429170; rs7689110; rs34763060; rs2171194; rs35003502; rs34851032; rs11322673; rs7439562; rs4694361; rs35261981; rs34205711; rs2306744; rs7689093; rs28671303; rs28687395; rs12642438; rs1385985; rs3733399; rs6446977; rs6836323; rs7656269

# Metabolic_Enzyme_1_General_References:
1996353; 2013338; 9342341

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5229

# Metabolic_Enzyme_2_Name:
5'-nucleotidase precursor

# Metabolic_Enzyme_2_Synonyms:
Ecto-5'-nucleotidase; 5'-NT; CD73 antigen

# Metabolic_Enzyme_2_Gene_Name:
NT5E

# Metabolic_Enzyme_2_Protein_Sequence:
>5'nucleotidase precursor
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ

# Metabolic_Enzyme_2_Number_of_Residues:
574

# Metabolic_Enzyme_2_Molecular_Weight:
63368

# Metabolic_Enzyme_2_Theoretical_pI:
7.04

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  hydrolase activity, acting on ester bonds
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides

# Metabolic_Enzyme_2_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_2_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF02872:5_nucleotid_C;
PF00149:Metallophos

# Metabolic_Enzyme_2_Signals:
1-26

# Metabolic_Enzyme_2_Transmembrane_Regions:
556-573

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
23897

# Metabolic_Enzyme_2_SwissProt_ID:
5NTD_HUMAN (P21589)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
NT5E

# Metabolic_Enzyme_2_Geneatlas_id:
NT5E

# Metabolic_Enzyme_2_hgnc_id:
HGNC:8021

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Metabolic_Enzyme_2_Gene_Sequence:
>1725 bp
ATGTGTCCCCGAGCCGCGCGGGCGCCCGCGACGCTACTCCTCGCCCTGGGCGCGGTGCTG
TGGCCTGCGGCTGGCGCCTGGGAGCTTACGATTTTGCACACCAACGACGTGCACAGCCGG
CTGGAGCAGACCAGCGAGGACTCCAGCAAGTGCGTCAACGCCAGCCGCTGCATGGGTGGC
GTGGCTCGGCTCTTCACCAAGGTTCAGCAGATCCGCCGCGCCGAACCCAACGTGCTGCTG
CTGGACGCCGGCGACCAGTACCAGGGCACTATCTGGTTCACCGTGTACAAGGGCGCCGAG
GTGGCGCACTTCATGAACGCCCTGCGCTACGATGCCATGGCACTGGGAAATCATGAATTT
GATAATGGTGTGGAAGGACTGATCGAGCCACTCCTCAAAGAGGCCAAATTTCCAATTCTG
AGTGCAAACATTAAAGCAAAGGGGCCACTAGCATCTCAAATATCAGGACTTTATTTGCCA
TATAAAGTTCTTCCTGTTGGTGATGAAGTTGTGGGAATCGTTGGATACACTTCCAAAGAA
ACCCCTTTTCTCTCAAATCCAGGGACAAATTTAGTGTTTGAAGATGAAATCACTGCATTA
CAACCTGAAGTAGATAAGTTAAAAACTCTAAATGTGAACAAAATTATTGCACTGGGACAT
TCGGGTTTTGAAATGGATAAACTCATCGCTCAGAAAGTGAGGGGTGTGGACGTCGTGGTG
GGAGGACACTCCAACACATTTCTTTACACAGGCAATCCACCTTCCAAAGAGGTGCCTGCT
GGGAAGTACCCATTCATAGTCACTTCTGATGATGGGCGGAAGGTTCCTGTAGTCCAGGCC
TATGCTTTTGGCAAATACCTAGGCTATCTGAAGATCGAGTTTGATGAAAGAGGAAACGTC
ATCTCTTCCCATGGAAATCCCATTCTTCTAAACAGCAGCATTCCTGAAGATCCAAGCATA
AAAGCAGACATTAACAAATGGAGGATAAAATTGGATAATTATTCTACCCAGGAATTAGGG
AAAACAATTGTCTATCTGGATGGCTCCTCTCAATCATGCCGCTTTAGAGAATGCAACATG
GGCAACCTGATTTGTGATGCAATGATTAACAACAACCTGAGACACACGGATGAAATGTTC
TGGAACCACGTATCCATGTGCATTTTAAATGGAGGTGGTATCCGGTCGCCCATTGATGAA
CGCAACAATGGCACAATTACCTGGGAGAACCTGGCTGCTGTATTGCCCTTTGGAGGCACA
TTTGACCTAGTCCAGTTAAAAGGTTCCACCCTGAAGAAGGCCTTTGAGCATAGCGTGCAC
CGCTACGGCCAGTCCACTGGAGAGTTCCTGCAGGTGGGCGGAATCCATGTGGTGTATGAT
CTTTCCCGAAAACCTGGAGACAGAGTAGTCAAATTAGATGTTCTTTGCACCAAGTGTCGA
GTGCCCAGTTATGACCCTCTCAAAATGGACGAGGTATATAAGGTGATCCTCCCAAACTTC
CTGGCCAATGGTGGAGATGGGTTCCAGATGATAAAAGATGAATTATTAAGACATGACTCT
GGTGACCAAGATATCAACGTGGTTTCTACATATATCTCCAAAATGAAAGTAATTTATCCA
GCAGTTGAAGGTCGGATCAAGTTTTCCACAGGAAGTCACTGCCATGGAAGCTTTTCTTTA
ATATTTCTTTCACTTTGGGCAGTGATCTTTGTTTTATACCAATAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X55740

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_2_Locus:
6q14-q21

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
2129526; 8566797; 2173922; 9651114

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5315

# Metabolic_Enzyme_3_Name:
Thymidine kinase 2, mitochondrial precursor

# Metabolic_Enzyme_3_Synonyms:
Mt-TK

# Metabolic_Enzyme_3_Gene_Name:
TK2

# Metabolic_Enzyme_3_Protein_Sequence:
>Thymidine kinase 2, mitochondrial precursor
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIA
SGKTTCLEFF
SNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLD
RHTRPQVSSVRLMERSIHSAR
YIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDL
IVYLRTNPETCYQRLKKRCREEEKVIPLEYLE
AIHHLHEEWLIKGSLFPMAAPVLVIEA
DHHHMERMLELFEQNRDRILTPENRKHCP

# Metabolic_Enzyme_3_Number_of_Residues:
266

# Metabolic_Enzyme_3_Molecular_Weight:
31142

# Metabolic_Enzyme_3_Theoretical_pI:
8.58

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs

# Metabolic_Enzyme_3_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_3_Reaction:
ATP + thymidine = ADP + thymidine 5'-phosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01712:dNK

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.7.1.21

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1905969

# Metabolic_Enzyme_3_SwissProt_ID:
KITM_HUMAN (O00142)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
TK2

# Metabolic_Enzyme_3_Geneatlas_id:
TK2

# Metabolic_Enzyme_3_hgnc_id:
HGNC:11831

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_3_Gene_Sequence:
>705 bp

ATGGGTGCGTTCTGCCAGCGTCCTAGCAGTGATAAAGAACAGGAAAAAGAGAAAAAATC
AGTGATCTGTG
TCGAGGGCAATATTGCAGGTGGGAAGACGACATGCCTGGAATTCTTCT
CCAACGCGACAGACGTCGAGGT
GTTAACGGAGCCTGTGTCCAAGTGGAGAAATGTCCGT
GGCCACAATCCTCTGGGCCTGATGTACCACGAT
GCCTCTCGCTGGGGTCTTACGCTACA
GACTTATGTGCAGCTCACCATGCTGGACAGGCATACTCGTCCTC
AGGTGTCATCTGTAC
GGTTGATGGAGAGGTCGATTCACAGCGCAAGATACATTTTTGTAGAAAACCTGTA
TAGA
AGTGGGAAGATGCCAGAAGTGGACTATGTAGTTCTGTCGGAATGGTTTGACTGGATCTTG
AGGAAC
ATGGACGTGTCTGTTGATTTGATAGTTTACCTTCGGACCAATCCTGAGACTTG
TTACCAGAGGTTAAAGA
AGAGATGCAGGGAAGAGGAGAAGGTCATTCCGCTGGAATACC
TGGAAGCAATTCACCATCTCCATGAGGA
GTGGCTCATCAAAGGCAGCCTTTTCCCCATG
GCAGCCCCTGTTCTGGTGATTGAGGCTGACCACCACATG
GAGAGGATGTTAGAACTCTT
TGAACAAAATCGGGATCGAATATTAACTCCAGAGAATCGGAAGCATTGCC
CATAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U77088

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_3_Locus:
16q22-q23.1

# Metabolic_Enzyme_3_SNPs:
rs3743716; rs3743715; rs880530; rs3743712; rs28171; rs755717; rs13334391; rs11859474; rs7191420; rs3826160; rs10492904; rs8064139; rs9930226; rs8044223; rs4783639; rs13331952; rs12448325; rs2241618; rs1366213; rs4783654; rs4783655; rs12445633; rs3826161; rs9932597; rs16956600; rs2288399; rs9924426; rs662089; rs2303776; rs9924955; rs37176; rs4783646; rs9924301; rs12102747; rs2241619; rs3743714; rs2241620; rs13331838; rs16956603; rs7196467; rs11865664; rs16956605; rs12447515; rs755716; rs9927697; rs7201934; rs37175; rs3743713; rs16956609; rs9934461; rs3743711; rs34931863; rs10454065; rs35138698; rs9930576; rs34946221; rs34364005; rs34974830; rs11378667; rs4441262; rs4783563; rs5817591; rs4783635; rs36122550; rs7191325; rs12928320; rs34922912; rs984375; rs5817593; rs4783643; rs4783628; rs34611947; rs35796755; rs397690; rs41377345; rs4783645; rs8047367; rs7189418; rs34482717; rs7498573; rs34207747; rs9673833; rs35291905; rs13339200; rs5817592; rs7201353; rs28626568; rs10709269; rs28667656; rs4783617; rs28454745; rs34214117; rs11643785; rs34613947; rs1346481; rs11383723; rs13338614; rs11334281; rs34906745; rs34484474; rs37177; rs35473118; rs384261; rs36049416; rs1108281; rs12444469; rs12449200; rs13333315; rs1428106; rs16956627; rs16956693; rs2002907; rs2232722; rs2232724; rs2232725; rs37178; rs3785086; rs3785087; rs3785088; rs4783659; rs7199632; rs725131; rs7498942; rs8054664; rs8058090; rs9796829; rs9933115

# Metabolic_Enzyme_3_General_References:
9079672; 9989599; 11687801; 12391347

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5802

# Metabolic_Enzyme_4_Name:
Cytidine deaminase

# Metabolic_Enzyme_4_Synonyms:
Cytidine aminohydrolase

# Metabolic_Enzyme_4_Gene_Name:
CDA

# Metabolic_Enzyme_4_Protein_Sequence:
>Cytidine deaminase
MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACY
PLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKP
DGTYIVMTVQELLPSSFGPEDLQKTQ

# Metabolic_Enzyme_4_Number_of_Residues:
146

# Metabolic_Enzyme_4_Molecular_Weight:
16185

# Metabolic_Enzyme_4_Theoretical_pI:
6.95

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  cytidine deaminase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleoside metabolism
Process:  pyrimidine nucleoside metabolism
Process:  pyrimidine ribonucleoside metabolism
Process:  cytidine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis

# Metabolic_Enzyme_4_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_4_Reaction:
cytidine + H2O = uridine + ammonia

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00383:dCMP_cyt_deam_1

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.5.4.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
598149

# Metabolic_Enzyme_4_SwissProt_ID:
CDD_HUMAN (P32320)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CDA

# Metabolic_Enzyme_4_Geneatlas_id:
CDA

# Metabolic_Enzyme_4_hgnc_id:
HGNC:1712

# Metabolic_Enzyme_4_PDB_ID:
1MQ0

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_4_Gene_Sequence:
>441 bp
ATGGCCCAGAAGCGTCCTGCCTGCACCCTGAAGCCTGAGTGTGTCCAGCAGCTGCTGGTT
TGCTCCCAGGAGGCCAAGAAGTCAGCCTACTGCCCCTACAGTCACTTTCCTGTGGGGGCT
GCCCTGCTCACCCAGGAGGGGAGAATCTTCAAAGGGTGCAACATAGAAAATGCCTGCTAC
CCGCTGGGCATCTGTGCTGAACGGACCGCTATCCAGAAGGCCGTCTCAGAAGGGTACAAG
GATTTCAGGGCAATTGCTATCGCCAGTGACATGCAAGATGATTTTATCTCTCCATGTGGG
GCCTGCAGGCAAGTCATGAGAGAGTTTGGCACCAACTGGCCCGTGTACATGACCAAGCCG
GATGGTACGTATATTGTCATGACGGTCCAGGAGCTGCTGCCCTCCTCCTTTGGGCCTGAG
GACCTGCAGAAGACTCAGTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
L27943

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_4_Locus:
1p36.2-p35

# Metabolic_Enzyme_4_SNPs:
rs2072671; rs1048977; rs602950; rs1781459; rs818194; rs12402391; rs818199; rs818196; rs558946; rs580032; rs818207; rs1689924; rs10916824; rs3738130; rs527912; rs10799647; rs577042; rs10916829; rs12404655; rs818193; rs498617; rs1253920; rs572529; rs818192; rs818197; rs477155; rs589942; rs12036993; rs517483; rs10916828; rs818198; rs11579252; rs471760; rs2985316; rs7523472; rs4655226; rs6659399; rs10916825; rs7548190; rs11579101; rs12407778; rs7534998; rs11578210; rs1781461; rs12068596; rs12119998; rs11583986; rs7535303; rs10799648; rs7523547; rs10916826; rs563329; rs12406106; rs11580375; rs818200; rs12072405; rs12120002; rs7523557; rs11801036; rs588485; rs7535200; rs7513317; rs1253921; rs7537463; rs488991; rs617782; rs10916827; rs7515668; rs500534; rs557219; rs818201; rs526987; rs10916830; rs12127536; rs506586; rs7537761; rs12072407; rs2320237; rs11582454; rs12401770; rs546692; rs11580377; rs542038; rs12072411; rs10916831; rs7545140; rs472629; rs573337; rs818202; rs1253904; rs532545; rs6690069; rs10916832; rs10916833; rs10916822; rs552722; rs603412; rs17854868; rs35163879; rs3215400; rs528031; rs1048980; rs34306899; rs602946; rs35247557; rs5772909; rs35125816; rs35859441; rs36002777; rs12131589; rs34293111; rs35045423; rs36106578; rs34634228; rs35916142; rs12123808; rs12145503; rs34652519; rs12029060; rs11584381; rs35668998; rs7414028; rs35869652; rs11589869; rs9970283; rs28646077; rs35735696; rs12030776; rs12036909; rs35182793; rs12141867; rs12075735; rs12722974; rs1253482; rs12022958; rs34008190; rs10628782; rs12737642; rs6676236; rs34347193; rs12072318; rs12059454; rs12119997; rs12125531; rs12401583; rs1152993; rs35187698; rs4655228; rs34809737; rs6679821; rs35806956; rs12039573; rs34822300; rs1253481; rs12024909; rs6657978; rs11272233; rs11579996; rs35088359; rs34840123; rs34904959; rs818206; rs12120392; rs35234793; rs34988653; rs6688783; rs41467355; rs12740823; rs11591189; rs9970233; rs6665553; rs35285740; rs1689925; rs34995697; rs12143372; rs28591485; rs34722632; rs11334996; rs3072072; rs9970226; rs12029033; rs35351279; rs12731069; rs11580211; rs28743049; rs12752560; rs692943; rs12123445; rs12135846; rs34901070; rs35637551; rs35770611; rs34861922; rs5772908; rs34862360; rs7531198; rs12092374; rs4259612; rs1689926; rs12744559; rs12737656; rs34715988; rs4655227; rs34918162; rs34185271; rs12045976; rs10916823; rs12240109; rs12726436; rs476790; rs12117048; rs33942385; rs10601038; rs12095662; rs10711308; rs12128671; rs10753504; rs10916836; rs10916837; rs1572487; rs1614627; rs1689916; rs1781457; rs485716; rs485833; rs540282; rs586422; rs650264; rs652536; rs6687370; rs6695655; rs678980; rs680748

# Metabolic_Enzyme_4_General_References:
7923172; 9878810; 9596658; 8422236

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5237

# Metabolic_Enzyme_5_Name:
Cytosolic purine 5'-nucleotidase

# Metabolic_Enzyme_5_Synonyms:
5'-nucleotidase cytosolic II

# Metabolic_Enzyme_5_Gene_Name:
NT5C2

# Metabolic_Enzyme_5_Protein_Sequence:
>Cytosolic purine 5'nucleotidase
MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVY
KSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLV
CAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTS
CETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMK
EVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGT
VLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKS
KKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQ
RRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAA
HVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLA
PQEITHCHDEDDDEEEEEEEE

# Metabolic_Enzyme_5_Number_of_Residues:
561

# Metabolic_Enzyme_5_Molecular_Weight:
64970

# Metabolic_Enzyme_5_Theoretical_pI:
6.05

# Metabolic_Enzyme_5_GO_Classification:
Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides

# Metabolic_Enzyme_5_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_5_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF05761:5_nucleotid

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_5_GenBank_ID_Protein:
633071

# Metabolic_Enzyme_5_SwissProt_ID:
5NTC_HUMAN (P49902)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
NT5C2

# Metabolic_Enzyme_5_Geneatlas_id:
NT5C2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:8022

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1686 bp
ATGTCGACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGAT
AAGCATGCCCTGAAAAAGTATCGTCGAGAAGCCTATCATCGGGTGTTTGTGAACCGAAGT
TTAGCAATGGAAAAGATAAAGTGTTTTGGTTTTGATATGGATTATACCCTTGCTGTGTAC
AAGTCCCCAGAGTATGAGTCCCTTGGTTTTGAGCTTACTGTGGAGAGATTAGTTTCTATT
GGCTATCCCCAGGAGTTGCTCAGCTTTGCTTATGATTCTACATTCCCTACCAGGGGACTT
GTCTTTGACACACTGTATGGAAATCTTTTGAAAGTCGATGCCTATGGAAACCTCTTGGTC
TGTGCACATGGATTTAACTTTATAAGGGGACCAGAAACTAGAGAACAGTATCCAAATAAA
TTTATCCAGCGAGATGATACTGAAAGATTTTACATTCTGAACACACTATTCAACCTACCA
GAGACCTACCTGTTGGCCTGCCTAGTAGATTTTTTTACTAATTGTCCCAGATATACCAGT
TGTGAAACAGGATTTAAAGATGGGGACCTCTTCATGTCCTACCGGAGTATGTTCCAGGAT
GTAAGAGATGCTGTTGACTGGGTTCATTACAAGGGCTCCCTTAAGGAAAAGACAGTTGAA
AATCTTGAGAAGTATGTAGTCAAAGATGGAAAACTGCCTTTGCTTCTGAGCCGGATGAAG
GAAGTAGGGAAAGTATTTCTTGCTACCAACAGTGACTATAAATATACAGATAAAATTATG
ACTTACCTGTTTGACTTCCCACATGGCCCCAAGCCTGGGAGCTCCCATCGACCATGGCAG
TCCTACTTTGACTTGATCTTGGTGGATGCACGGAAACCACTCTTTTTTGGAGAAGGCACA
GTACTGCGTCAGGTGGATACTAAAACTGGCAAGCTGAAAATTGGTACCTACACAGGGCCC
CTACAGCATGGTATCGTCTACTCAGGAGGTTCTTCTGATACGATCTGTGACCTGTTGGGA
GCCAAGGGAAAAGACATTTTGTATATTGGAGATCACATTTTTGGGGACATTTTAAAATCA
AAGAAACGGCAAGGGTGGCGAACTTTTTTGGTGATTCCTGAACTCGCACAGGAGCTACAT
GTCTGGACTGACAAGAGTTCACTTTTCGAAGAACTTCAGAGCTTGGATATTTTCTTGGCT
GAACTCTACAAGCATCTTGACAGCAGTAGCAATGAGCGTCCAGACATCAGTTCCATCCAG
AGACGTATTAAGAAAGTAACTCATGACATGGACATGTGCTATGGGATGATGGGAAGCCTG
TTTCGCAGTGGCTCCCGGCAGACCCTTTTTGCCAGTCAAGTGATGCGTTATGCTGACCTC
TATGCAGCATCTTTCATCAACCTGCTGTATTACCCTTTCAGCTACCTCTTCAGGGCTGCC
CATGTCTTGATGCCTCATGAATCAACGGTGGAGCACACACACGTAGATATCAATGAGATG
GAGTCTCCTCTTGCCACCCGGAACCGCACATCAGTGGATTTCAAAGACACTGACTACAAG
CGGCACCAGCTGACACGGTCAATTAGTGAGATTAAACCTCCCAACCTCTTCCCACTGGCC
CCCCAGGAAATTACACACTGCCATGACGAAGATGATGATGAAGAGGAGGAGGAGGAGGAA
GAATAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
D38524

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_5_Locus:
10q24.32-q24.33

# Metabolic_Enzyme_5_SNPs:
rs12262171; rs3740387; rs12253627; rs10786736; rs8139; rs7917650; rs10786741; rs7920251; rs10430665; rs7916854; rs12573199; rs11191598; rs1163238; rs12573200; rs10883843; rs7092407; rs12573221; rs4917997; rs11191593; rs11191596; rs10786744; rs1163236; rs10883842; rs10786742; rs10786743; rs7075552; rs7077097; rs2863728; rs3758543; rs7077291; rs10748838; rs3087681; rs12240508; rs732998; rs10883830; rs7899084; rs2274340; rs2182348; rs2066322; rs7908960; rs7912517; rs7067970; rs3740386; rs7896547; rs11191554; rs1163249; rs2281877; rs2863727; rs3781281; rs2274341; rs2148198; rs7897663; rs3781282; rs10883832; rs1926029; rs1935323; rs1926030; rs746293; rs6584539; rs2066323; rs9919482; rs3740385; rs12773916; rs12414232; rs10786737; rs12413046; rs12412038; rs2274339; rs11598702; rs1541213; rs11191580; rs11191553; rs10509765; rs10509766; rs3977751; rs12220375; rs4917996; rs7896433; rs6584540; rs1926037; rs3736922; rs11191577; rs2148197; rs11191561; rs7080935; rs11191555; rs10883833; rs12219304; rs1926036; rs7913920; rs10883834; rs11191558; rs11191582; rs11191589; rs10883831; rs12220743; rs10786738; rs11191560; rs10748837; rs11191578; rs3781280; rs7896519; rs12217501; rs11191573; rs7067741; rs6584541; rs7067663; rs2148200; rs10883840; rs11191583; rs12415199; rs9919485; rs11191557; rs17094683; rs7895154; rs12355120; rs2153774; rs10786739; rs7915816; rs7081075; rs1807298; rs3861984; rs11191572; rs12571568; rs12416331; rs11191586; rs10883839; rs12766205; rs1163239; rs10883837; rs11191584; rs1163247; rs17115452; rs11191556; rs7909022; rs12775302; rs9633712; rs11191581; rs11191576; rs10883836; rs11191549; rs7095304; rs10883845; rs11191550; rs11191548; rs11191602; rs10748839; rs1141101; rs1055812; rs1141100; rs1141098; rs1141099; rs34351688; rs34394526; rs34058246; rs11191594; rs35224704; rs34747231; rs12774207; rs11191595; rs34699185; rs11280184; rs1163237; rs7073259; rs34064597; rs11191601; rs35525740; rs35291480; rs12264098; rs35978588; rs12241986; rs7091462; rs12774182; rs34756486; rs35695488; rs12252236; rs3834416; rs11191600; rs34136949; rs7080242; rs12763243; rs34003851; rs11191585; rs11191551; rs36111455; rs34966121; rs35464534; rs35541240; rs11191571; rs35913488; rs34223002; rs11440429; rs41287482; rs35653865; rs34963818; rs11191559; rs11191568; rs35436872; rs17795366; rs1163246; rs34060908; rs34963563; rs34915846; rs12780509; rs2153773; rs34211645; rs3736924; rs34758128; rs36059537; rs35302704; rs12255989; rs34104646; rs11191574; rs11191564; rs35745742; rs34644789; rs5787481; rs34863357; rs11191590; rs12774840; rs2148196; rs12763944; rs3215816; rs34207290; rs35752695; rs34445719; rs28419708; rs4421684; rs28516969; rs12265498; rs12767422; rs12772228; rs34908445; rs11191570; rs17115449; rs35195396; rs12243923; rs10883835; rs12779263; rs11302933; rs7091173; rs11375439; rs7071103; rs35146429; rs35338839; rs34268365; rs34130454; rs35898850; rs3861983; rs28404041; rs35621207; rs3736923; rs5787482; rs7075048; rs34307431; rs35348020; rs34349473; rs1773930; rs11191566; rs34870452; rs35078544; rs35123178; rs12265545; rs1163241; rs3949893; rs7904067; rs12775841; rs35821867; rs12775904; rs7915032; rs5028036; rs35254502; rs1163248; rs35365027; rs34876862; rs11191565; rs12772280; rs10709724; rs35085852; rs35351555; rs12774513; rs10710371; rs11296588; rs12243903; rs28605898; rs34241930; rs34549427; rs11451961; rs34403968; rs12761657; rs34397864; rs3062737; rs36092020; rs35109679; rs34011916; rs34435560; rs11191562; rs4917383; rs34067380; rs34202831; rs11191563; rs2148199; rs34133379; rs35763505; rs12414385; rs1163240; rs12262258; rs11191588; rs34664715; rs12414374; rs35133717; rs3837340; rs10614009; rs2153772; rs11191587; rs11403586; rs11191575; rs1060240; rs34588165; rs11191552; rs41317254; rs1163245; rs1064099; rs12268552; rs34833988; rs11191603; rs12253716; rs12412924; rs3841710; rs34551510; rs12246784; rs12781668; rs1064098; rs10458729; rs10786740; rs10786745; rs10883829; rs10883841; rs11191547; rs1163235; rs12261294; rs12571345; rs12785223; rs17115427; rs4307650; rs4917382; rs4917995; rs7074395; rs7092200; rs726010; rs763914; rs7921996; rs943035

# Metabolic_Enzyme_5_General_References:
7999131

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5807

# Metabolic_Enzyme_6_Name:
Protein disulfide-isomerase A4 precursor

# Metabolic_Enzyme_6_Synonyms:
Protein ERp-72; ERp72

# Metabolic_Enzyme_6_Gene_Name:
PDIA4

# Metabolic_Enzyme_6_Protein_Sequence:
>Protein disulfideisomerase A4 precursor
MRPRKAFLLLLLLGLVQLLAVAGAEGPDEDSSNRENAIEDEEEEEEEDDDEEEDDLEVKE
ENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKI
DATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTL
VLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAE
TDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQEFL
KDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLVVMQP
EKFQSKYEPRSHMMDVQGSTQDSAIKDFVLKYALPLVGHRKVSNDAKRYTRRPLVVVYYS
VDFSFDYRAATQFWRSKVLEVAKDFPEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILD
ESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVM
DPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGF
PTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTKEEL

# Metabolic_Enzyme_6_Number_of_Residues:
645

# Metabolic_Enzyme_6_Molecular_Weight:
72933

# Metabolic_Enzyme_6_Theoretical_pI:
4.70

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  transporter activity
Function:  electron transporter activity
Function:  catalytic activity
Function:  isomerase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  endoplasmic reticulum

# Metabolic_Enzyme_6_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_6_Specific_Function:
Catalyzes the rearrangement of -S-S- bonds in proteins

# Metabolic_Enzyme_6_Pathway:
Not Available

# Metabolic_Enzyme_6_Reaction:
Catalyses the rearrangement of -S-S- bonds in proteins

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00085:Thioredoxin

# Metabolic_Enzyme_6_Signals:
1-20

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 5.3.4.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
181508

# Metabolic_Enzyme_6_SwissProt_ID:
PDIA4_HUMAN (P13667)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
PDIA4

# Metabolic_Enzyme_6_Geneatlas_id:
PDIA4

# Metabolic_Enzyme_6_hgnc_id:
HGNC:30167

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Metabolic_Enzyme_6_Gene_Sequence:
>1938 bp
ATGAGGCCCCGGAAAGCCTTCCTGCTCCTGCTGCTCTTGGGGCTGGTGCAGCTGCTGGCC
GTGGCGGGTGCCGAGGGCCCGGACGAGGATTCTTCTAACAGAGAAAATGCCATTGAGGAT
GAAGAGGAGGAGGAGGAGGAAGATGATGATGAGGAAGAAGACGACTTGGAAGTTAAGGAA
GAAAATGGAGTCTTGGTCCTAAATGATGCAAACTTTGATAATTTTGTGGCTGACAAAGAC
ACAGTGCTGCTGGAGTTTTATGCTCCATGGTGTGGACATTGCAAGCAGTTTGCTCCGGAA
TATGAAAAAATTGCCAACATATTAAAGGATAAAGATCCTCCCATTCCTGTTGCCAAGATC
GATGCAACCTCAGCGTCTGTGCTGGCCAGCAGGTTTGATGTGAGTGGCTACCCCACCATC
AAGATCCTTAAGAAGGGGCAGGCTGTAGACTACGAGGGCTCCAGAACCCAGGAAGAAATT
GTTGCCAAGGTCAGAGAAGTCTCCCAGCCCGACTGGACGCCTCCACCAGAAGTCACGCTT
GTGTTGACCAAAGAGAACTTTGATGAAGTTGTGAATGATGCAGATATCATTCTGGTGGAG
TTTTATGCCCCATGGTGTGGACACTGCAAGAAACTTGCCCCCGAGTATGAGAAGGCCGCC
AAGGAGCTCAGCAAGCGTTCTCCTCCAATTCCCCTGGCAAAGGTCGACGCCACCGCAGAA
ACAGACCTGGCCAAGAGGTTTGATGTCTCTGGCTATCCCACCCTGAAAATTTTCCGCAAA
GGAAGGCCTTATGACTACAACGGCCCACGAGAAAAATATGGAATCGTTGATTACATGATC
GAGCAGTCCGGGCCTCCCTCCAAGGAGATTCTGACCCTGAAGCAGGTCCAGGAGTTCCTG
AAGGATGGAGACGATGTCATCATCATCGGGGTCTTTAAGGGGGAGAGTGACCCAGCCTAC
CAGCAATACCAGGATGCCGCTAACAACCTGAGAGAAGATTACAAATTTCACCACACTTTC
AGCACAGAAATAGCAAAGTTCTTGAAAGTCTCCCAGGGGCAGTTGGTTGTAATGCAGCCT
GAGAAATTCCAGTCCAAGTATGAGCCCCGGAGCCACATGATGGACGTCCAGGGCTCCACC
CAGGACTCGGCCATCAAGGACTTCGTGCTGAAGTACGCCCTGCCCCTGGTTGGCCACCGC
AAGGTGTCAAACGATGCTAAGCGCTACACCAGGCGCCCCCTGGTGGTCGTCTACTACAGT
GTGGACTTCAGCTTTGATTACAGAGCTGCAACTCAGTTTTGGCGGAGCAAAGTCCTAGAG
GTGGCCAAGGACTTCCCTGAGTACACCTTTGCCATTGCGGACGAAGAGGACTATGCTGGG
GAGGTGAAGGACCTGGGGCTCAGCGAGAGTGGGGAGGATGTCAATGCCGCCATCCTGGAC
GAGAGTGGGAAGAAGTTCGCCATGGAGCCAGAGGAGTTTGACTCTGACACCCTCCGCGAG
TTTGTCACTGCTTTCAAAAAAGGAAAACTGAAGCCAGTCATCAAATCCCAGCCAGTGCCC
AAGAACAACAAGGGACCCGTCAAGGTCGTGGTGGGAAAGACCTTTGACTCCATTGTGATG
GACCCCAAGAAGGACGTCCTCATCGAGTTCTACGCGCCATGGTGCGGGCACTGCAAGCAG
CTAGAGCCCGTGTACAACAGCCTGGCCAAGAAGTACAAGGGCCAAAAGGGCCTGGTCATC
GCCAAGATGGACGCCACTGCCAACGACGTCCCCAGCGACCGCTATAAGGTGGAGGGCTTC
CCCACCATCTACTTCGCCCCCAGTGGGGACAAAAAGAACCCAGTTAAATTTGAGGGTGGA
GACAGAGATCTGGAGCATTTGAGCAAGTTTATAGAAGAACATGCCACAAAACTGAGCAGG
ACCAAGGAAGAGCTTTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
J05016

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_6_Locus:
7q35

# Metabolic_Enzyme_6_SNPs:
rs2290971; rs35207074; rs1052549; rs9065; rs2306169; rs6969638; rs1382192; rs6464930; rs4727006; rs4727005; rs7795577; rs2306172; rs1382191; rs6464929; rs728451; rs4727009; rs11980538; rs12534095; rs2290970; rs6965276; rs1551927; rs7778448; rs6952916; rs7793916; rs4727007; rs718411; rs11976467; rs1962977; rs7777113; rs1020940; rs3779039; rs6978068; rs1551926; rs7787508; rs6464933; rs6948711; rs6977370; rs6963547; rs7808287; rs6944853; rs7781312; rs11974099; rs6965440; rs10085877; rs10272564; rs10269104; rs4727008; rs6947874; rs1962975; rs9918632; rs1962976; rs7455991; rs899129; rs6464928; rs6954405; rs10236640; rs11974627; rs6953222; rs6953180; rs10269506; rs11509175; rs17171156; rs7812195; rs10236808; rs11971515; rs2306170; rs7807788; rs11546292; rs6971353; rs1052626; rs11546290; rs35572261; rs11546289; rs13243678; rs1052599; rs6958855; rs10243245; rs35590396; rs6978647; rs13244008; rs5888347; rs11410607; rs28497061; rs28532077; rs3084442; rs3084443; rs34125437; rs34989074; rs10229806; rs4725794; rs35343205; rs10271571; rs10233535; rs35359302; rs12704057; rs13247593; rs41278746; rs34480442; rs10548888; rs2306171; rs28463009; rs6973873; rs35339835; rs12334067; rs10258441; rs6464934; rs13230041; rs41278749; rs12333828; rs4725795; rs34656815; rs35909633; rs11315544; rs10262716; rs35693482; rs13230031; rs10233906; rs35881176; rs35129885; rs35825784; rs11361769; rs10671079; rs35304005; rs35786243; rs35812027; rs34909003; rs3204774; rs11365856; rs6973217; rs10609306; rs11414114; rs28379751; rs11981448; rs10224999; rs10251886; rs12667507; rs4725793; rs716817; rs716818; rs7776474; rs7798153

# Metabolic_Enzyme_6_General_References:
2549034; 2002068

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5803

# Metabolic_Enzyme_7_Name:
Activation-induced cytidine deaminase

# Metabolic_Enzyme_7_Synonyms:
Cytidine aminohydrolase

# Metabolic_Enzyme_7_Gene_Name:
AICDA

# Metabolic_Enzyme_7_Protein_Sequence:
>Activationinduced cytidine deaminase
MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSLDFGYLRNKNGCHVELL
FLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTARLYFCEDRK
AEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFKAWEGLHENSVRLSRQLRRIL
LPLYEVDDLRDAFRTLGL

# Metabolic_Enzyme_7_Number_of_Residues:
198

# Metabolic_Enzyme_7_Molecular_Weight:
23954

# Metabolic_Enzyme_7_Theoretical_pI:
9.66

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses

# Metabolic_Enzyme_7_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_7_Reaction:
cytidine + H2O = uridine + ammonia

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF05240:APOBEC_C;
PF08210:APOBEC_N

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.5.4.5

# Metabolic_Enzyme_7_GenBank_ID_Protein:
9988410

# Metabolic_Enzyme_7_SwissProt_ID:
AICDA_HUMAN (Q9GZX7)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
AICDA

# Metabolic_Enzyme_7_Geneatlas_id:
AICDA

# Metabolic_Enzyme_7_hgnc_id:
HGNC:13203

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_7_Gene_Sequence:
>597 bp
ATGGACAGCCTCTTGATGAACCGGAGGAAGTTTCTTTACCAATTCAAAAATGTCCGCTGG
GCTAAGGGTCGGCGTGAGACCTACCTGTGCTACGTAGTGAAGAGGCGTGACAGTGCTACA
TCCTTTTCACTGGACTTTGGTTATCTTCGCAATAAGAACGGCTGCCACGTGGAATTGCTC
TTCCTCCGCTACATCTCGGACTGGGACCTAGACCCTGGCCGCTGCTACCGCGTCACCTGG
TTCACCTCCTGGAGCCCCTGCTACGACTGTGCCCGACATGTGGCCGACTTTCTGCGAGGG
AACCCCAACCTCAGTCTGAGGATCTTCACCGCGCGCCTCTACTTCTGTGAGGACCGCAAG
GCTGAGCCCGAGGGGCTGCGGCGGCTGCACCGCGCCGGGGTGCAAATAGCCATCATGACC
TTCAAAGATTATTTTTACTGCTGGAATACTTTTGTAGAAAACCATGAAAGAACTTTCAAA
GCCTGGGAAGGGCTGCATGAAAATTCAGTTCGTCTCTCCAGACAGCTTCGGCGCATCCTT
TTGCCCCTGTATGAGGTTGATGACTTACGAGACGCATTTCGTACTTTGGGACTTTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AB040431

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_7_Locus:
12p13

# Metabolic_Enzyme_7_SNPs:
rs2028373; rs12307097; rs11046349; rs7304723; rs2580874; rs2518144; rs2580873; rs1561560; rs2580875; rs12306110; rs1561559; rs2580876; rs3794318; rs17792729; rs1347978; rs3794316; rs1439868; rs2165191; rs3794317; rs11613792; rs1561562; rs1561561; rs714629; rs7316523; rs9971686; rs1561557; rs12297074; rs2019057; rs9971703; rs714630; rs3205190; rs10601618; rs34604633; rs11324989; rs7138990; rs35273657; rs10623739; rs12310085; rs28681214; rs11614281; rs5796316; rs1439869; rs12307620; rs34730872; rs12312451; rs5796317; rs33998240; rs35699718; rs1982214; rs12321976; rs34030304; rs1561558; rs1345004; rs9971705; rs28835914; rs12321209; rs12824576; rs2889653; rs7305961; rs7306108

# Metabolic_Enzyme_7_General_References:
10950930; 11007475; 11544457

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
7643

# Metabolic_Enzyme_8_Name:
DNA

# Metabolic_Enzyme_8_Synonyms:
cytosine-5-methyltransferase 1; Dnmt1; DNA methyltransferase HsaI; DNA MTase HsaI; MCMT; M.HsaI

# Metabolic_Enzyme_8_Gene_Name:
DNMT1

# Metabolic_Enzyme_8_Protein_Sequence:
>
DNAMPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEI
KNQLCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSEA
RRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAK
RKPQEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEER
DEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAKR
RPEEKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKKMARAKTVMNSKTHPPKCIQCG
QYLDDPDLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHG
HLCPIDTGLIEKNIELFFSGSAKPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALI
GFSTSFAEYILMDPSPEYAPIFGLMQEKIYISKIVVEFLQSNSDSTYEDLINKIETTVPP
SGLNLNRFTEDSLLRHAQFVVEQVESYDEAGDSDEQPIFLTPCMRDLIKLAGVTLGQRRA
QARRQTIRHSTREKDRGPTKATTTKLVYQIFDTFFAEQIEKDDREDKENAFKRRRCGVCE
VCQQPECGKCKACKDMVKFGGSGRSKQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKK
MHQGKKKKQNKNRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLA
RVTALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYK
APSENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCA
RLAEMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVK
RPRKEPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIKIR
VNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPECVQVYSM
GGPNRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEPEIEIKLP
KLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKL
VMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDY
YRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILA
AAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEV
RNGASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWR
DLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGKACDPAARQFNTLIP
WCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQ
GFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESASAKIKEEEAAKD

# Metabolic_Enzyme_8_Number_of_Residues:
1616

# Metabolic_Enzyme_8_Molecular_Weight:
183167

# Metabolic_Enzyme_8_Theoretical_pI:
7.81

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  protein binding
Function:  transcription factor binding
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  DNA metabolism
Process:  DNA modification
Process:  DNA alkylation
Process:  DNA methylation
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Metabolic_Enzyme_8_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_8_Specific_Function:
Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2

# Metabolic_Enzyme_8_Pathway:
map00271  Methionine metabolism

# Metabolic_Enzyme_8_Reaction:
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF01426:BAH;
PF06464:DMAP_binding;
PF00145:DNA_methylase;
PF02008:zf-CXXC

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.1.1.37

# Metabolic_Enzyme_8_GenBank_ID_Protein:
1632819

# Metabolic_Enzyme_8_SwissProt_ID:
DNMT1_HUMAN (P26358)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
DNMT1

# Metabolic_Enzyme_8_Geneatlas_id:
DNMT1

# Metabolic_Enzyme_8_hgnc_id:
HGNC:2976

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_8_Gene_Sequence:
>4851 bp
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTG
CCCGACGATGTCCGCAGGCGGCTCAAAGATTTGGAAAGAGACAGCTTAACAGAAAAGGAA
TGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCT
AAAGTCAAATCCCTTTTAAATAAAGATTTGTCCTTGGAGAACGGTGCTCATGCTTACAAC
CGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGG
AGCAAGTCCGATGGAGAGGCTAAGCCTGAACCTTCACCTAGCCCCAGGATTACAAGGAAA
AGCACCAGGCAAACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCT
CAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAGGAAGAAGACAAAGACCAG
GATGAGAAGAGACGTAGAGTTACATCCAGAGAACGAGTTGCTAGACCGCTTCCTGCAGAA
GAACCTGAAAGAGCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAA
GAAGAAAAGAGACTCCGAAGTCAAACCAAAGAACCAACACCCAAACAGAAACTGAAGGAG
GAGCCGGACAGAGAAGCCAGGGCAGGCGTGCAGGCTGACGAGGACGAAGATGGAGACGAG
AAAGATGAGAAGAAGCACAGAAGTCAACCCAAAGATCTAGCTGCCAAACGGAGGCCCGAA
GAAAAAGAACCTGAAAAAGTAAATCCACAGATTTCTGATGAAAAAGACGAGGATGAAAAG
GAGGAGAAGAGACGCAAAACGACCCCCAAAGAACCAACGGAGAAAAAAATGGCTCGCGCC
AAAACAGTCATGAACTCCAAGACCCACCCTCCCAAGTGCATTCAGTGCGGGCAGTACCTG
GACGACCCTGACCTCAAATATGGGCAGCACCCACCAGACGCGGTGGATGAGCCACAGATG
CTGACAAATGAGAAGCTGTCCATCTTTGATGCCAACGAGTCTGGCTTTGAGAGTTATGAG
GCGCTTCCCCAGCACAAACTGACCTGCTTCAGTGTGTACTGTAAGCACGGTCACCTGTGT
CCCATCGACACCGGCCTCATCGAGAAGAATATCGAACTCTTCTTTTCTGGTTCAGCAAAA
CCAATCTATGATGATGACCCGTCTCTTGAAGGTGGTGTTAATGGCAAAAATCTTGGCCCC
ATAAATGAATGGTGGATCACTGGCTTTGATGGAGGTGAAAAGGCCCTCATCGGCTTCAGC
ACCTCATTTGCCGAATACATTCTGATGGATCCCAGTCCCGAGTATGCGCCCATATTTGGG
CTGATGCAGGAGAAGATCTACATCAGCAAGATTGTGGTGGAGTTCCTGCAGAGCAATTCC
GACTCGACCTATGAGGACCTGATCAACAAGATCGAGACCACGGTTCCTCCTTCTGGCCTC
AACTTGAACCGCTTCACAGAGGACTCCCTCCTGCGACACGCGCAGTTTGTGGTGGAGCAG
GTGGAGAGTTATGACGAGGCCGGGGACAGTGATGAGCAGCCCATCTTCCTGACGCCCTGC
ATGCGGGACCTGATCAAGCTGGCTGGGGTCACGCTGGGACAGAGGCGAGCCCAGGCGAGG
CGGCAGACCATCAGGCATTCTACCAGGGAGAAGGACAGGGGACCCACGAAAGCCACCACC
ACCAAGCTGGTCTACCAGATCTTCGATACTTTCTTCGCAGAGCAAATTGAAAAGGATGAC
AGAGAAGACAAGGAGAACGCCTTTAAGCGCCGGCGATGTGGCGTCTGTGAGGTGTGTCAG
CAGCCTGAGTGTGGGAAATGTAAAGCCTGCAAGGACATGGTTAAATTTGGTGGCAGTGGA
CGGAGCAAGCAGGCTTGCCAAGAGCGGAGGTGTCCCAATATGGCCATGAAGGAGGCAGAT
GACGATGAGGAAGTCGATGATAACATCCCAGAGATGCCGTCACCCAAAAAAATGCACCAG
GGGAAGAAGAAGAAACAGAACAAGAATCGCATCTCTTGGGTCGGAGAAGCCGTCAAGACT
GATGGGAAGAAGAGTTACTATAAGAAGGTGTGCATTGATGCGGAAACCCTGGAAGTGGGG
GACTGTGTCTCTGTTATTCCAGATGATTCCTCAAAACCGCTGTATCTAGCAAGGGTCACG
GCGCTGTGGGAGGACAGCAGCAACGGGCAGATGTTTCACGCCCACTGGTTCTGCGCTGGG
ACAGACACAGTCCTCGGGGCCACGTCGGACCCTCTGGAGCTGTTCTTGGTGGATGAATGT
GAGGACATGCAGCTTTCATATATCCACAGCAAAGTGAAAGTCATCTACAAAGCCCCCTCC
GAAAACTGGGCCATGGAGGGAGGCATGGATCCCGAGTCCCTGCTGGAGGGGGACGACGGG
AAGACCTACTTCTACCAGCTGTGGTATGATCAAGACTACGCGAGATTCGAGTCCCCTCCA
AAAACCCAGCCAACAGAGGACAACAAGTTCAAATTCTGTGTGAGCTGTGCCCGTCTGGCT
GAGATGAGGCAAAAAGAAATCCCCAGGGTCCTGGAGCAGCTCGAGGACCTGGATAGCCGG
GTCCTCTACTACTCAGCCACCAAGAACGGCATCCTGTACCGAGTTGGTGATGGTGTGTAC
CTGCCCCCTGAGGCCTTCACGTTCAACATCAAGCTGTCCAGTCCCGTGAAACGCCCACGG
AAGGAGCCCGTGGATGAGGACCTGTACCCAGAGCACTACCGGAAATACTCCGACTACATC
AAAGGCAGCAACCTGGATGCCCCTGAGCCCTACCGAATTGGCCGGATCAAAGAGATCTTC
TGTCCCAAGAAGAGCAACGGCAGGCCCAATGAGACTGACATCAAAATCCGGGTCAACAAG
TTCTACAGGCCTGAGAACACCCACAAGTCCACTCCAGCGAGCTACCACGCAGACATCAAC
CTGCTCTACTGGAGCGACGAGGAGGCCGTGGTGGACTTCAAGGCTGTGCAGGGCCGCTGC
ACCGTGGAGTATGGGGAGGACCTGCCCGAGTGCGTCCAGGTGTACTCCATGGGCGGCCCC
AACCGCTTCTACTTCCTCGAGGCCTATAATGCAAAGAGCAAAAGCTTTGAAGATCCTCCC
AACCATGCCCGTAGCCCTGGAAACAAAGGGAAGGGCAAGGGAAAAGGGAAGGGCAAGCCC
AAGTCCCAAGCCTGTGAGCCGAGCGAGCCAGAGATAGAGATCAAGCTGCCCAAGCTGCGG
ACCCTGGATGTGTTTTCTGGCTGCGGGGGGTTGTCGGAGGGATTCCACCAAGCAGGCATC
TCTGACACGCTGTGGGCCATCGAGATGTGGGACCCTGCGGCCCAGGCGTTCCGGCTGAAC
AACCCCGGCTCCACAGTGTTCACAGAGGACTGCAACATCCTGCTGAAGCTGGTCATGGCT
GGGGAGACCACCAACTCCCGCGGCCAGCGGCTGCCCCAGAAGGGAGACGTGGAGATGCTG
TGCGGCGGGCCGCCCTGCCAGGGCTTCAGCGGCATGAACCGCTTCAATTCGCGCACCTAC
TCCAAGTTCAAAAACTCTCTGGTGGTTTCCTTCCTCAGCTACTGCGACTACTACCGGCCC
CGGTTCTTCCTCCTGGAGAATGTCAGGAACTTTGTCTCCTTCAAGCGCTCCATGGTCCTG
AAGCTCACCCTCCGCTGCCTGGTCCGCATGGGCTATCAGTGCACCTTCGGCGTGCTGCAG
GCCGGTCAGTACGGCGTGGCCCAGACTAGGAGGCGGGCCATCATCCTGGCCGCGGCCCCT
GGAGAGAAGCTCCCTCTGTTCCCGGAGCCACTGCACGTGTTTGCTCCCCGGGCCTGCCAG
CTGAGCGTGGTGGTGGATGACAAGAAGTTTGTGAGCAACATAACCAGGTTGAGCTCGGGT
CCTTTCCGGACCATCACGGTGCGAGACACGATGTCCGACCTGCCGGAGGTGCGGAATGGA
GCCTCGGCACTGGAGATCTCCTACAACGGGGAGCCTCAGTCCTGGTTCCAGAGGCAGCTC
CGGGGCGCACAGTACCAGCCCATCCTCAGGGACCACATCTGTAAGGACATGAGTGCATTG
GTGGCTGCCCGCATGCGGCACATCCCCTTGGCCCCAGGGTCAGACTGGCGCGATCTGCCC
AACATCGAGGTGCGGCTCTCAGACGGCACCATGGCCAGGAAGCTGCGGTATACCCACCAT
GACAGGAAGAACGGCCGCAGCAGCTCTGGGGCCCTCCGTGGGGTCTGCTCCTGCGTGGAA
GCCGGCAAAGCCTGCGACCCCGCAGCCAGGCAGTTCAACACCCTCATCCCCTGGTGCCTG
CCCCACACCGGGAACCGGCACAACCACTGGGCTGGCCTCTATGGAAGGCTCGAGTGGGAC
GGCTTCTTCAGCACAACCGTCACCAACCCCGAGCCCATGGGCAAGCAGGGCCGCGTGCTC
CACCCAGAGCAGCACCGTGTGGTGAGCGTGCGGGAGTGTGCCCGCTCCCAGGGCTTCCCT
GACACCTACCGGCTCTTCGGCAACATCCTGGACAAGCACCGGCAGGTGGGCAATGCCGTG
CCACCGCCCCTGGCCAAAGCCATTGGCTTGGAGATCAAGCTTTGTATGTTGGCCAAAGCC
CGAGAGAGTGCCTCAGCTAAAATAAAGGAGGAGGAAGCTGCTAAGGACTAG

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X63692

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_8_Locus:
19p13.2

# Metabolic_Enzyme_8_SNPs:
rs8111085; rs16999593; rs2228613; rs2228611; rs721186; rs16999358; rs2162560; rs2241531; rs759920; rs4804124; rs2114724; rs8112801; rs10420321; rs8101626; rs6511685; rs2290684; rs9305012; rs2288350; rs2336691; rs4804489; rs4804490; rs7253378; rs10421746; rs4804494; rs2011034; rs10418707; rs10854076; rs12611113; rs11880553; rs6511677; rs2162559; rs7257298; rs10426223; rs11672909; rs2288349; rs7253062; rs4804125; rs6511570; rs10416200; rs8111808; rs7258766; rs10413185; rs10407514; rs2336690; rs6511611; rs7247491; rs11879603; rs6511678; rs6511610; rs12609071; rs10422286; rs8108925; rs8101866; rs10405735; rs11880388; rs12611271; rs10423673; rs12609152; rs11881310; rs12460767; rs4804493; rs10423341; rs1863771; rs8112895; rs10426062; rs11670357; rs10408180; rs10414661; rs35622143; rs2229858; rs9676676; rs13784; rs11488; rs35641518; rs4804492; rs12971774; rs10405146; rs28501615; rs17333908; rs5827090; rs28787955; rs3745271; rs34858632; rs11668641; rs35863536; rs4804491; rs36048626; rs3079975; rs6511612; rs3745270; rs35281765; rs11670667; rs34178852; rs34288732; rs11670269; rs35697879; rs12975631; rs36026709; rs7259561; rs10412016; rs33916380; rs34258350; rs11882187; rs36061584; rs35472577; rs7253898; rs11671475; rs35583463; rs34374135; rs35918857; rs35841466; rs919188; rs34352285; rs10422231; rs35310173; rs35795837; rs5827091; rs11670665; rs34173597; rs34559337; rs34387000; rs34081018; rs5827089; rs34539107; rs35217527; rs10425105; rs28607407; rs35693490; rs34495234; rs34918104; rs35744087; rs10412529; rs8104968; rs10413872; rs28493477; rs5827088; rs3217302; rs35012154; rs11672866; rs34369468; rs2290683; rs34993621; rs34705022; rs34225538; rs34252933; rs34930749; rs35238334; rs8102368; rs35336927; rs34698448; rs3079962; rs11880117; rs34719680; rs34784157; rs3079979; rs34064945; rs10422860; rs35721499; rs35245682; rs35635942; rs35490778; rs12979227; rs8103303; rs11666205; rs36001002; rs4804126; rs3745269; rs3214543; rs28398225; rs10404658; rs10407697; rs3079977; rs28706753; rs28679320; rs7248120; rs35454711; rs35029521; rs34268510; rs12984523; rs34911732; rs35600922; rs10403947; rs10416722; rs12462004; rs2116940

# Metabolic_Enzyme_8_General_References:
1594447; 8940105; 10449766; 10753866; 9302295; 10947852; 10888872; 10888886; 10325416

# Metabolic_Enzyme_8_References:
15534852; 15746193; 15899874; 16219133

# Metabolic_Enzyme_9_ID:
8666

# Metabolic_Enzyme_9_Name:
Hypothetical protein NT5C1B

# Metabolic_Enzyme_9_Synonyms:
Not Available

# Metabolic_Enzyme_9_Gene_Name:
NT5C1B

# Metabolic_Enzyme_9_Protein_Sequence:
>Hypothetical protein NT5C1
BMQENPEAWAQGIVREIRQTRDSQPLEYSRTSPTEWKSSSQRRGIYPASTQLDRNSLSEQ
QQQQREDEDDYEAAYWASMRSFYEKNPSCSRPWPPKPKNAITIALSSCALFNMVDGRKIY
EQEGLEKYMEYQLTNENVILTPGPAFRFVKALQYVNARLRDLYPDEQDLFDIVLMTNNHA
QVGVRLINSVNHYGLLIDRFCLTGGKDPIGYLKAYLTNLYIAADSEKVQEAIQEGIASAT
MFDGAKDMAYCDTQLRVAFDGDAVLFSDESEHFTKEHGLDKFFQYDTLCESKPLAQGPLK
GFLEDLGRLQKKFYAKNERLLCPIRTYLVTARSAASSGARVLKTLRRWGLEIDEALFLAG
APKSPILVKIRPHIFFDDHMFHIEGAQRLGSIAAYGFNKKFSS

# Metabolic_Enzyme_9_Number_of_Residues:
402

# Metabolic_Enzyme_9_Molecular_Weight:
45860

# Metabolic_Enzyme_9_Theoretical_pI:
6.41

# Metabolic_Enzyme_9_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
 Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
Not Available

# Metabolic_Enzyme_9_Pathway:
Not Available

# Metabolic_Enzyme_9_Reaction:
Not Available

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_9_Signals:
Not Available

# Metabolic_Enzyme_9_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_9_GenBank_ID_Protein:
62702336

# Metabolic_Enzyme_9_SwissProt_ID:
Q53RX2_HUMAN (Q53RX2)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
NT5C1B

# Metabolic_Enzyme_9_Geneatlas_id:
NT5C1B

# Metabolic_Enzyme_9_hgnc_id:
HGNC:17818

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_9_Gene_Sequence:
>1209 bp
ATGCAAGAGAATCCGGAGGCCTGGGCCCAAGGCATCGTGCGGGAAATCCGCCAGACCCGG
GACTCGCAGCCGCTGGAATATTCGCGCACGTCCCCCACCGAGTGGAAGTCCTCCAGCCAG
CGCAGGGGGATCTACCCCGCCTCCACCCAGCTGGACCGCAACTCTCTGTCCGAGCAGCAG
CAGCAGCAGCGGGAGGACGAGGACGACTACGAGGCTGCCTACTGGGCATCCATGAGGTCG
TTCTACGAGAAGAACCCGAGCTGCTCGCGCCCCTGGCCGCCCAAACCCAAGAACGCCATC
ACCATTGCTCTCTCATCCTGCGCGCTCTTCAACATGGTGGACGGCAGGAAAATCTACGAG
CAAGAGGGTCTGGAAAAGTACATGGAGTATCAGCTCACCAATGAGAACGTCATCCTGACC
CCGGGCCCGGCGTTCCGCTTCGTCAAGGCACTACAGTATGTCAATGCTAGACTCCGTGAT
CTATATCCTGATGAACAGGACTTATTTGATATTGTACTGATGACTAATAACCATGCCCAA
GTGGGAGTGCGGCTTATAAACAGCGTCAATCACTACGGCTTACTGATTGACCGCTTCTGT
CTGACCGGGGGAAAAGACCCCATTGGCTATTTGAAGGCATATCTTACCAACTTGTATATT
GCTGCAGATTCTGAAAAAGTGCAAGAGGCAATACAAGAAGGTATTGCCTCTGCGACAATG
TTTGATGGAGCCAAAGACATGGCTTACTGTGACACTCAGCTCCGTGTAGCCTTTGATGGG
GATGCTGTCCTCTTCTCTGATGAGTCTGAACATTTTACCAAGGAGCATGGGCTCGACAAA
TTCTTCCAGTATGATACATTATGTGAAAGTAAGCCTCTTGCTCAGGGTCCCCTAAAAGGC
TTTCTGGAAGATTTAGGCAGACTGCAAAAGAAGTTCTATGCCAAAAATGAACGGTTACTT
TGTCCTATCAGGACCTACCTGGTTACAGCTAGGAGTGCAGCCAGTTCAGGCGCCCGTGTG
CTGAAGACCCTTCGACGCTGGGGTCTAGAGATAGACGAAGCTCTTTTCCTTGCTGGAGCC
CCCAAAAGTCCCATCTTGGTGAAGATCCGGCCCCACATCTTCTTTGATGACCACATGTTC
CACATTGAAGGGGCACAGAGGTTAGGTTCCATCGCAGCTTATGGCTTTAATAAAAAATTC
AGTAGTTAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AC079148

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_9_Locus:
2p24.2

# Metabolic_Enzyme_9_SNPs:
rs3902946; rs16985301; rs16985306; rs3747660; rs2346137; rs6720633; rs7594728; rs6531109; rs6710367; rs7557821; rs4832608; rs11893074; rs16985296; rs7561652; rs2317857; rs16985292; rs16985290; rs6741218; rs11096544; rs35590292; rs10183289; rs17752103; rs11885013; rs17701334; rs16985293; rs11903725; rs7604190; rs4832609; rs7592099; rs16985311; rs16985310; rs3810839; rs17852342; rs34254789; rs7594519; rs34129467; rs7605480; rs35165251; rs7603601; rs34836771; rs34186303; rs35711606; rs35729409; rs34953851; rs11291136; rs28474708; rs3046807; rs34660980; rs35519366; rs3046840; rs35419885; rs7557722; rs4300829; rs7592233; rs13020403; rs36121694; rs34127788; rs11889898; rs13403096; rs13411442; rs1373776; rs16985281; rs16985284; rs17751951; rs2346135; rs2346136; rs34722188; rs35805648; rs3810838; rs3910894

# Metabolic_Enzyme_9_General_References:
Not Available

# Metabolic_Enzyme_9_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7663

# Macromolecular_Interacting_Partner_1_Name:
Signal transducer and activator of transcription 3

# Macromolecular_Interacting_Partner_1_Synonyms:
Acute-phase response factor

# Macromolecular_Interacting_Partner_1_Gene_Name:
STAT3

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Signal transducer and activator of transcription 3
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
770

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
88069

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.23

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00017:SH2;
PF01017:STAT_alpha;
PF02864:STAT_bind;
PF02865:STAT_int

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
475789

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
STAT3_HUMAN (P40763)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
STAT3

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
STAT3

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:11364

# Macromolecular_Interacting_Partner_1_PDB_ID:
1BG1

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>2313 bp
ATGGCCCAATGGAATCAGCTACAGCAGCTTGACACACGGTACCTGGAGCAGCTCCATCAG
CTCTACAGTGACAGCTTCCCAATGGAGCTGCGGCAGTTTCTGGCCCCTTGGATTGAGAGT
CAAGATTGGGCATATGCGGCCAGCAAAGAATCACATGCCACTTTGGTGTTTCATAATCTC
CTGGGAGAGATTGACCAGCAGTATAGCCGCTTCCTGCAAGAGTCGAATGTTCTCTATCAG
CACAATCTACGAAGAATCAAGCAGTTTCTTCAGAGCAGGTATCTTGAGAAGCCAATGGAG
ATTGCCCGGATTGTGGCCCGGTGCCTGTGGGAAGAATCACGCCTTCTACAGACTGCAGCC
ACTGCGGCCCAGCAAGGGGGCCAGGCCAACCACCCCACAGCAGCCGTGGTGACGGAGAAG
CAGCAGATGCTGGAGCAGCACCTTCAGGATGTCCGGAAGAGAGTGCAGGATCTAGAACAG
AAAATGAAAGTGGTAGAGAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTCAAG
AGTCAAGGAGACATGCAAGATCTGAATGGAAACAACCAGTCAGTGACCAGGCAGAAGATG
CAGCAGCTGGAACAGATGCTCACTGCGCTGGACCAGATGCGGAGAAGCATCGTGAGTGAG
CTGGCGGGGCTTTTGTCAGCGATGGAGTACGTGCAGAAAACTCTCACGGACGAGGAGCTG
GCTGACTGGAAGAGGCGGCAACAGATTGCCTGCATTGGAGGCCCGCCCAACATCTGCCTA
GATCGGCTAGAAAACTGGATAACGTCATTAGCAGAATCTCAACTTCAGACCCGTCAACAA
ATTAAGAAACTGGAGGAGTTGCACCAAAAAGTTTCCTACAAAGGGGACCCCATTGTACAG
CACCGGCCGATGCTGGAGGAGAGGATCGTGGAGCTGTTCAGAAACTTAATGAAAAGTGCC
TTTGTGGTGGAGCGGCAGCCCTGCATGCCCATGCATCCTGACCGGCCCCTCGTCATCAAG
ACCGGCGTCCAGTTCACTACTAAAGTCAGGTTGCTGGTCAAGTTCCCTGAGTTGAATTAT
CAGCTTAAAATTAAAGTGTGCATTGACAAAGACTCTGGGGACGTTGCAGCTCTCAGAGGA
TCCCGGAAATTTAACATTCTGGGCACAAACACAAAAGTGATGAACATGGAAGAATCCAAC
AACGGCAGCCTCTCTGCAGAATTCAAACACTTGACCCTGAGGGAGCAGAGATGTGGGAAT
GGGGGCCGAGCCAATTGTGATGCTTCCCTGATTGTGACTGAGGAGCTGCACCTGATCACC
TTTGAGACCGAGGTGTATCACCAAGGTCTCAAGATTGACCTAGAGACCCACTCCTTGTCA
GTTGTGGTGATCTCCAACATCTGTCAGATGCCAAATGCCTGGGCGTCCATCCTGTGGTAC
AACATGCTGACCAACAATCCCAAGAATGTGAACTTCTTCACTAAGCCGCCAATTGGAACC
TGGGACCAAGTGGCCGAGGTGCTCAGCTGGCAGTTCTCGTCCACCACCAAGCGGGGGCTG
AGCATCGAGCAGCTGACAACGCTGGCTGAGAAGCTCCTAGGGCCTGGTGTGAACTACTCA
GGGTGTCAGATCACATGGGCTAACTTCTGCAAAGAAAACATGGCTGGCAAGGGCTTCTCC
TACTGGGTCTGGCTAGACAATATCATCGACCTTGTGAAAAAGTATATCTTGGCCCTTTGG
AATGAAGGGTACATCATGGGTTTCATCAGCAAGGAGCGGGAGCGGGCCATCTTGAGCACT
AAGCCCCCAGGCACCTTCCTGCTGCGCTTCAGTGAAAGCAGCAAAGAAGGAGGCGTCACT
TTCACTTGGGTGGAGAAGGACATCAGCGGTAAGACCCAGATCCAGTCCGTGGAACCATAC
ACAAAGCAGCAGCTGAACAACATGTCATTTGCTGAAATCATCATGGGCTATAAGATCATG
GATGCTACCAATATCCTGTTGTCTCCACTTGTCTATCTCTATCCTGACATTCCCAAGGAG
GAGGCATTCGGGAAGTATTGTCGGCCAGAGAGCCAGGAGCATCCTGAAGCTGACCCAGGT
AGCGCTGCCCCATACCTGAAGACCAAGTTTATCTGTGTGACACCAACGACCTGCAGCAAT
ACCATTGACCTGCCGATGTCCCCCCGCGCTTTAGATTCATTGATGCAGTTTGGAAATAAT
GGTGAAGGTGCTGAACCCTCAGCAGGAGGGCAGTTTGAGTCCCTCACCTTTGACATGGAG
TTGACCTCGGAGTGCGCTACCTCCCCCATGTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
L29277

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_1_Locus:
17q21.31

# Macromolecular_Interacting_Partner_1_SNPs:
rs1064116; rs17882069; rs17880940; rs1064113; rs1905340; rs957970; rs1053005; rs744166; rs957971; rs1053004; rs1026916; rs4796792; rs9912773; rs1053023; rs8073836; rs6503697; rs4796791; rs9891119; rs12949918; rs8068748; rs9891867; rs7224416; rs11079042; rs7219059; rs4287619; rs3785898; rs16967719; rs8074288; rs8073517; rs1905341; rs13342031; rs7219739; rs17882369; rs7224007; rs7211777; rs4103200; rs12602466; rs3744483; rs3883338; rs9913597; rs11867382; rs8070763; rs17881668; rs17879497; rs12602449; rs7216516; rs17878746; rs17881438; rs7211264; rs6503698; rs9303328; rs9895473; rs17887094; rs17881805; rs17881664; rs8071537; rs17884307; rs17885629; rs12937642; rs8076051; rs17884090; rs17879207; rs17883506; rs12942547; rs17882436; rs12947808; rs7214610; rs1963988; rs17884541; rs8066517; rs17593222; rs17883029; rs3736164; rs11869886; rs4796646; rs17885278; rs9898794; rs1963987; rs2306580; rs8072566; rs6503696; rs2306581; rs9898884; rs8072391; rs2293152; rs9889396; rs3809758; rs7206960; rs9890635; rs8069645; rs8081431; rs7214964; rs7215104; rs8066464; rs9909659; rs8075442; rs6503695; rs9915916; rs9896889; rs7216201; rs7501954; rs8081037; rs7206950; rs8064496; rs10153241; rs8074524; rs9890802; rs3816769; rs3869550; rs17881940; rs3736161; rs12721576; rs7217655; rs3869549; rs7213632; rs16967689; rs4265875; rs7220550; rs17880900; rs17881621; rs12601611; rs7224339; rs7213633; rs12721583; rs17882163; rs17887066; rs17885291; rs7215694; rs8078731; rs2291281; rs17879752; rs17878412; rs17879738; rs17881759; rs17884478; rs1222187; rs17880538; rs17880983; rs17886724; rs17885350; rs17878930; rs17879287; rs17878696; rs17882516; rs17879962; rs8080551; rs11870967; rs17885431; rs17882334; rs17878674; rs17887068; rs17884929; rs17885741; rs12103893; rs2291282; rs17886496; rs17880347; rs3736162; rs17881032; rs17879513; rs17882035; rs17886256; rs17882406; rs17881320; rs17879198; rs17881938; rs8069836; rs17879459; rs4796793; rs16967725; rs17405722; rs17885036; rs17884075; rs909056; rs17880962; rs17878478; rs1141129; rs11547455; rs1064110; rs1803125; rs34460718; rs1064122; rs1064111; rs1064117; rs1141145; rs1141118; rs1064115; rs1141121; rs1141122; rs1141119; rs1064121; rs1064118; rs1064112; rs1141120; rs1064114; rs1141117; rs1141123; rs1064119; rs1064120; rs1141131; rs1141144; rs1141111; rs35342182; rs1222186; rs4796644; rs8075676; rs12938189; rs17883843; rs17881974; rs34393906; rs11449147; rs34788284; rs35901220; rs11408644; rs10659012; rs34354144; rs12938193; rs1803126; rs11871210; rs34115235; rs34263131; rs12953155; rs34094936; rs7211035; rs17880712; rs34972443; rs9897389; rs41289087; rs3736163; rs12946759; rs7214139; rs34003618; rs12938463; rs12951192; rs12936225; rs7207492; rs11408645; rs35729990; rs11408950; rs16967716; rs35427318; rs12951971; rs11457025; rs35840966; rs10775; rs7350890; rs12949179; rs17883295; rs35585589; rs8064997; rs34479652; rs4519378; rs12942611; rs11328125; rs35561964; rs1231903; rs35314169; rs8071969; rs1236315; rs35987545; rs17883814; rs12952630; rs35896270; rs11378560; rs12603457; rs12325774; rs17886670; rs3169702; rs34291674; rs12946874; rs35857074; rs7221074; rs11379691; rs11440924; rs35099574; rs12938461; rs11444177; rs12452182; rs11398324; rs11339093; rs10706301; rs17884918; rs34559610; rs12945333; rs8069115; rs17881859; rs17880808; rs34054293; rs35398041; rs35950888; rs17884714; rs34923201; rs17879250; rs17879442; rs35184581; rs34165663; rs11657309; rs17880904; rs17879681; rs8066904; rs17884716; rs17880663; rs35863777; rs17878909; rs1312364; rs34846688; rs11656164; rs9909736; rs12950549; rs17883005; rs17886263; rs17885843; rs8077296; rs8081156; rs7221636; rs34330322; rs17882635; rs36055143; rs12946502; rs8064327; rs35159711; rs17882551; rs35455295; rs11318541; rs11285572; rs35499754; rs10706259; rs17884756; rs17879448; rs3830585; rs8072736; rs35162488; rs17878464; rs17879201; rs12943176; rs17884004; rs35432758; rs10657713; rs11392125; rs35885311; rs744284; rs17882079; rs33997807; rs35332755; rs1057935; rs11079043; rs1135669; rs1135670; rs11658772; rs12601982; rs16967738; rs17320971; rs2067694; rs2272087; rs2293154; rs2293155; rs3198502; rs4621023; rs9889942; rs9906989; rs9915299

# Macromolecular_Interacting_Partner_1_General_References:
7512451; 9630560; 7701321; 12208879; 12023369

# Macromolecular_Interacting_Partner_1_References:
15354212; 16871283

# Macromolecular_Interacting_Partner_2_ID:
7816

# Macromolecular_Interacting_Partner_2_Name:
Histone deacetylase 1

# Macromolecular_Interacting_Partner_2_Synonyms:
HD1

# Macromolecular_Interacting_Partner_2_Gene_Name:
HDAC1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Histone deacetylase 1
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
482

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
55104

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.16

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Function:  histone deacetylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid deacetylation
Process:  histone deacetylation
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_2_General_Function:
Chromatin structure and dynamics 

# Macromolecular_Interacting_Partner_2_Specific_Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00850:Hist_deacetyl

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
1277084

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
HDAC1_HUMAN (Q13547)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
HDAC1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
HDAC1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:4852

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1449 bp
ATGGCGCAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGGGATGTTGGA
AATTACTATTATGGACAAGGCCACCCAATGAAGCCTCACCGAATCCGCATGACTCATAAT
TTGCTGCTCAACTATGGTCTCTACCGAAAAATGGAAATCTATCGCCCTCACAAAGCCAAT
GCTGAGGAGATGACCAAGTACCACAGCGATGACTACATTAAATTCTTGCGCTCCATCCGT
CCAGATAACATGTCGGAGTACAGCAAGCAGATGCAGAGATTCAACGTTGGTGAGGACTGT
CCAGTATTCGATGGCCTGTTTGAGTTCTGTCAGTTGTCTACTGGTGGTTCTGTGGCAAGT
GCTGTGAAACTTAATAAGCAGCAGACGGACATCGCTGTGAATTGGGCTGGGGGCCTGCAC
CATGCAAAGAAGTCCGAGGCATCTGGCTTCTGTTACGTCAATGATATCGTCTTGGCCATC
CTGGAACTGCTAAAGTATCACCAGAGGGTGCTGTACATTGACATTGATATTCACCATGGT
GACGGCGTGGAAGAGGCCTTCTACACCACGGACCGGGTCATGACTGTGTCCTTTCATAAG
TATGGAGAGTACTTCCCAGGAACTGGGGACCTACGGGATATCGGGGCTGGCAAAGGCAAG
TATTATGCTGTTAACTACCCGCTCCGAGACGGGATTGATGACGAGTCCTATGAGGCCATT
TTCAAGCCGGTCATGTCCAAAGTAATGGAGATGTTCCAGCCTAGTGCGGTGGTCTTACAG
TGTGGCTCAGACTCCCTATCTGGGGATCGGTTAGGTTGCTTCAATCTAACTATCAAAGGA
CACGCCAAGTGTGTGGAATTTGTCAAGAGCTTTAACCTGCCTATGCTGATGCTGGGAGGC
GGTGGTTACACCATTCGTAACGTTGCCCGGTGCTGGACATATGAGACAGCTGTGGCCCTG
GATACGGAGATCCCTAATGAGCTTCCATACAATGACTACTTTGAATACTTTGGACCAGAT
TTCAAGCTCCACATCAGTCCTTCCAATATGACTAACCAGAACACGAATGAGTACCTGGAG
AAGATCAAACAGCGACTGTTTGAGAACCTTAGAATGCTGCCGCACGCACCTGGGGTCCAA
ATGCAGGCGATTCCTGAGGACGCCATCCCTGAGGAGAGTGGCGATGAGGACGAAGACGAC
CCTGACAAGCGCATCTCGATCTGCTCCTCTGACAAACGAATTGCCTGTGAGGAAGAGTTC
TCCGATTCTGAAGAGGAGGGAGAGGGGGGCCGCAAGAACTCTTCCAACTTCAAAAAAGCC
AAGAGAGTCAAAACAGAGGATGAAAAAGAGAAAGACCCAGAGGAGAAGAAAGAAGTCACC
GAAGAGGAGAAAACCAAGGAGGAGAAGCCAGAAGCCAAAGGGGTCAAGGAGGAGGTCAAG
TTGGCCTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
U50079

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_2_Locus:
1p34

# Macromolecular_Interacting_Partner_2_SNPs:
rs8176782; rs6697130; rs7543692; rs16834954; rs16834956; rs16834958; rs16834963; rs16834957; rs12133048; rs17507358; rs12096858; rs17255809; rs690334; rs2127246; rs10914548; rs1741981; rs1140658; rs1140673; rs11541185; rs11541183; rs11541184; rs1140660; rs8176783; rs10914552; rs690332; rs35808493; rs12026405; rs552686; rs7533676; rs6679175; rs34899445; rs7512341; rs10914547; rs10914551; rs12723325; rs552733; rs34315355; rs34267128; rs12758327; rs10914546; rs12734422; rs34371852; rs10652556; rs34065217; rs10465520; rs690520; rs35894142; rs28419695; rs471372; rs35770915; rs34386633; rs552732; rs34447178; rs12727854; rs35678923; rs34021057; rs34742550; rs28372816; rs11589444; rs35790615; rs10465522; rs12022567; rs690006; rs690525; rs2019923; rs34403317; rs7544100; rs9699564; rs35191653; rs35577659; rs35345816; rs10465521; rs34304672; rs36212114; rs11459069; rs36212119; rs36212122; rs36211753; rs35299850; rs36212118; rs36212115; rs36212123; rs36212121; rs36212117; rs12090734; rs36212116; rs34992032; rs35764672; rs1042546; rs10914545; rs11576036; rs11576040; rs11576043; rs11807976; rs11809371; rs12048924; rs8176768; rs8176777; rs8176781

# Macromolecular_Interacting_Partner_2_General_References:
8602529; 8646880; 10487760; 10898795; 10669754; 11602581; 11331609; 11102443; 11427533; 12032081; 12670868; 12493763; 12482978; 12724404; 10904264

# Macromolecular_Interacting_Partner_2_References:
15746193; 16043219; 16464847

# Macromolecular_Interacting_Partner_3_ID:
8368

# Macromolecular_Interacting_Partner_3_Name:
DNA

# Macromolecular_Interacting_Partner_3_Synonyms:
cytosine-5-methyltransferase 3B; Dnmt3b; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; M.HsaIIIB

# Macromolecular_Interacting_Partner_3_Gene_Name:
DNMT3B

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>
DNAMKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSK
REVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERH
RPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDT
HGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFS
WWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVS
YRKAMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVV
NKSKVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSR
EQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSY
CTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLR
RRKDWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIK
VGKYVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNV
NPARKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECN
PVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTK
SNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVP
VIRHLFAPLKDYFACE

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
853

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
95752

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
8.52

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  DNA metabolism
Process:  DNA modification
Process:  DNA alkylation
Process:  DNA methylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Required for genome wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs

# Macromolecular_Interacting_Partner_3_Pathway:
map00271  Methionine metabolism

# Macromolecular_Interacting_Partner_3_Reaction:
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00145:DNA_methylase;
PF00855:PWWP

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
EC 2.1.1.37

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
5823166

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
DNM3B_HUMAN (Q9UBC3)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
DNMT3B

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
DNMT3B

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:2979

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>2313 bp
ATGAAGGGAGACACCAGGCATCTCAATGGAGAGGAGGACGCCGGCGGGAGGGAAGACTCG
ATCCTCGTCAACGGGGCCTGCAGCGACCAGTCCTCCGACTCGCCCCCAATCCTGGAGGCT
ATCCGCACCCCGGAGATCAGAGGCCGAAGATCAAGCTCGCGACTCTCCAAGAGGGAGGTG
TCCAGTCTGCTAAGCTACACACAGGACTTGACAGGCGATGGCGACGGGGAAGATGGGGAT
GGCTCTGACACCCCAGTCATGCCAAAGCTCTTCCGGGAAACCAGGACTCGTTCAGAAAGC
CCAGCTGTCCGAACTCGAAATAACAACAGTGTCTCCAGCCGGGAGAGGCACAGGCCTTCC
CCACGTTCCACCCGAGGCCGGCAGGGCCGCAACCATGTGGACGAGTCCCCCGTGGAGTTC
CCGGCTACCAGGTCCCTGAGACGGCGGGCAACAGCATCGGCAGGAACGCCATGGCCGTCC
CCTCCCAGCTCTTACCTTACCATCGACCTCACAGACGACACAGAGGACACACATGGGACG
CCCCAGAGCAGCAGTACCCCCTACGCCCGCCTAGCCCAGGACAGCCAGCAGGGGGGCATG
GAGTCCCCGCAGGTGGAGGCAGACAGTGGAGATGGAGACAGTTCAGAGTATCAGGATGGG
AAGGAGTTTGGAATAGGGGACCTCGTGTGGGGAAAGATCAAGGGCTTCTCCTGGTGGCCC
GCCATGGTGGTGTCTTGGAAGGCCACCTCCAAGCGACAGGCTATGTCTGGCATGCGGTGG
GTCCAGTGGTTTGGCGATGGCAAGTTCTCCGAGGTCTCTGCAGACAAACTGGTGGCACTG
GGGCTGTTCAGCCAGCACTTTAATTTGGCCACCTTCAATAAGCTCGTCTCCTATCGAAAA
GCCATGTACCATGCTCTGGAGAAAGCTAGGGTGCGAGCTGGCAAGACCTTCCCCAGCAGC
CCTGGAGACTCATTGGAGGACCAGCTGAAGCCCATGTTGGAGTGGGCCCACGGGGGCTTC
AAGCCCACTGGGATCGAGGGCCTCAAACCCAACAACACGCAACCAGAGAACAAGACTCGA
AGACGCACAGCTGACGACTCAGCCACCTCTGACTACTGCCCCGCACCCAAGCGCCTCAAG
ACAAATTGCTATAACAACGGCAAAGACCGAGGGGATGAAGATCAGAGCCGAGAACAAATG
GCTTCAGATGTTGCCAACAACAAGAGCAGCCTGGAAGATGGCTGTTTGTCTTGTGGCAGG
AAAAACCCCGTGTCCTTCCACCCTCTCTTTGAGGGGGGGCTCTGTCAGACATGCCGGGAT
CGCTTCCTTGAGCTGTTTTACATGTATGATGACGATGGCTATCAGTCTTACTGCACTGTG
TGCTGCGAGGGCCGAGAGCTGCTGCTTTGCAGCAACACGAGCTGCTGCCGGTGTTTCTGT
GTGGAGTGCCTGGAGGTGCTGGTGGGCACAGGCACAGCGGCCGAGGCCAAGCTTCAGGAG
CCCTGGAGCTGCTACATGTGTCTCCCGCAGCGCTGTCATGGCGTCCTGCGGCGCCGGAAG
GACTGGAACGTGCGCCTGCAGGCCTTCTTCACCAGTGACACGGGGCTTGAATACGAAGCC
CCCAAGCTGTACCCTGCCATTCCCGCAGCCCGAAGGCGGCCCATTCGAGTCCTGTCATTG
TTTGATGGCATCGCGACAGGCTACCTAGTCCTCAAAGAGTTGGGCATAAAGGTAGGAAAG
TACGTCGCTTCTGAAGTGTGTGAGGAGTCCATTGCTGTTGGAACCGTGAAGCACGAGGGG
AATATCAAATACGTGAACGACGTGAGGAACATCACAAAGAAAAATATTGAAGAATGGGGC
CCATTTGACTTGGTGATTGGCGGAAGCCCATGCAACGATCTCTCAAATGTGAATCCAGCC
AGGAAAGGCCTGTATGAGGGTACAGGCCGGCTCTTCTTCGAATTTTACCACCTGCTGAAT
TACTCACGCCCCAAGGAGGGTGATGACCGGCCGTTCTTCTGGATGTTTGAGAATGTTGTA
GCCATGAAGGTTGGCGACAAGAGGGACATCTCACGGTTCCTGGAGTGTAATCCAGTGATG
ATTGATGCCATCAAAGTTTCTGCTGCTCACAGGGCCCGATACTTCTGGGGCAACCTACCC
GGGATGAACAGGATCTTTGGCTTTCCTGTGCACTACACAGACGTGTCCAACATGGGCCGT
GGTGCCCGCCAGAAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTC
GCCCCTCTGAAGGACTACTTTGCATGTGAATAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF156487

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_3_Locus:
20q11.2

# Macromolecular_Interacting_Partner_3_SNPs:
rs17123590; rs2424922; rs6058891; rs17123657; rs6119965; rs875040; rs2424909; rs1883729; rs2424907; rs2424906; rs2424908; rs4911256; rs6058883; rs6119951; rs2424932; rs6119954; rs4911257; rs742630; rs1333469; rs4911254; rs6058875; rs2424905; rs4544521; rs6141813; rs6058896; rs6058874; rs2018002; rs1855349; rs6087420; rs6141812; rs6087999; rs10485500; rs4911255; rs1569686; rs1003521; rs6141807; rs6141811; rs6087995; rs6141806; rs2424904; rs6119282; rs6058872; rs6057641; rs11699834; rs11907740; rs8115823; rs13433362; rs6058880; rs17123571; rs4911253; rs2424910; rs2889703; rs2065576; rs2424915; rs910085; rs2424918; rs992472; rs6058893; rs4911110; rs4911107; rs2424914; rs6088008; rs2424913; rs6119967; rs4911263; rs875041; rs4911258; rs2424921; rs6058887; rs6119955; rs6057645; rs910084; rs4911261; rs660291; rs998382; rs6119285; rs2424928; rs6057648; rs4911260; rs910083; rs4911259; rs1003522; rs2424923; rs2235758; rs2424930; rs709046; rs6119969; rs4911262; rs6058888; rs4911108; rs2064350; rs1997797; rs6057647; rs1040553; rs8115360; rs1855350; rs1040555; rs6119968; rs2889702; rs2424924; rs7360212; rs1474738; rs2424920; rs6058889; rs1040554; rs17123621; rs6119284; rs1569687; rs6141814; rs2424926; rs2424917; rs6058894; rs2377668; rs6119962; rs6119957; rs17123658; rs6119286; rs17368519; rs2235759; rs6058890; rs6058892; rs2424925; rs1569688; rs2424912; rs993419; rs6119961; rs6119964; rs2424929; rs2424931; rs6058869; rs6087990; rs2424903; rs7263832; rs6058868; rs6141816; rs35846833; rs7354578; rs17123655; rs730823; rs35216603; rs6058885; rs6088005; rs11472205; rs2780646; rs35171367; rs2745869; rs3080493; rs33962299; rs6058884; rs6088001; rs35710599; rs11471852; rs11470764; rs6119953; rs11474600; rs11449585; rs35285794; rs28651027; rs7508830; rs6087992; rs2745868; rs35907993; rs13040503; rs35097322; rs6088003; rs35850884; rs6058876; rs15475; rs13433248; rs35056918; rs6087996; rs6058881; rs13036475; rs6087994; rs35015134; rs2889701; rs2424911; rs12185796; rs6058878; rs8119520; rs6087998; rs6141810; rs34614068; rs5841115; rs34007401; rs34062797; rs6058879; rs11482399; rs7272387; rs34168690; rs6057640; rs11449584; rs11483043; rs13433366; rs2780645; rs10625883; rs8182693; rs6088000; rs10633411; rs35041039; rs11356349; rs35554139; rs6119971; rs853855; rs6141805; rs7264790; rs6058882; rs34988842; rs6087991; rs2284645; rs11367842; rs35262859; rs33960116; rs6058877; rs35649229; rs3215552; rs13036474; rs6119952; rs6087997; rs6058871; rs6087993; rs35767454; rs4578931; rs34551940; rs6088002; rs6141809; rs6057642; rs35572823; rs10690184; rs2780644; rs34237297; rs28377882; rs6088011; rs11467304; rs11367843; rs35272629; rs35965317; rs11469900; rs11482544; rs6119966; rs6088004; rs6088010; rs4911109; rs34031725; rs2268319; rs6119960; rs4571133; rs34902104; rs6119970; rs11469402; rs34013500; rs6088006; rs6141817; rs8115015; rs11483143; rs11469349; rs35213238; rs35130294; rs34002628; rs2424916; rs6058895; rs11469084; rs33932894; rs11477763; rs1079957; rs5841117; rs11389019; rs6057643; rs33979693; rs6141347; rs35246123; rs11472645; rs35576810; rs35722862; rs34292062; rs2424919; rs34005307; rs11167180; rs11482880; rs35255239; rs33912850; rs8117681; rs35427476; rs863831; rs35994043; rs35507532; rs854575; rs8119395; rs34716138; rs3787143; rs36098970; rs2424927; rs863832; rs6088007; rs11697520; rs17123660; rs7354629; rs11480089; rs35541717; rs6088009; rs6141815; rs3838010; rs6119959; rs6119958; rs8119391; rs860549; rs41289866; rs6057644; rs11480729; rs11483142; rs34505873; rs33983546; rs10623814; rs11468163; rs865556; rs2300418; rs6119956; rs6058886; rs17123659; rs11449390; rs36039389; rs34072569; rs11431333; rs3080497; rs5841116; rs35928966; rs34371048; rs11471253; rs35691828; rs36133386; rs36233103; rs35155241; rs6058870; rs35471481; rs3092509; rs11470398; rs13038956; rs2424901; rs242542; rs242543; rs406193; rs437302; rs6058864; rs6058897; rs6141803; rs8118663; rs853858

# Macromolecular_Interacting_Partner_3_General_References:
10433969; 10647011; 11780052; 10325416; 11735126; 10555141; 10588719; 11102980

# Macromolecular_Interacting_Partner_3_References:
16247458

End of HMDB00014

Beginning of HMDB00015
# Accession_No:
HMDB00015

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-14 11:59:15

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Cortexolone

# Description:
Cortexolone is the precursor of cortisol. Accumulation of Cortexolone can happen in a defect known as congenital adrenal hyperplasia, which is due to 11-beta-hydroxylase deficiency, resulting in androgen excess, virilization, and hypertension. (PMID: 2022736)
A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities. (PubChem)

# Synonyms:
11-Deoxy-17-hydroxycorticosterone; 11-Deoxycortisol; 11-Deoxyhydrocortisone; 11-Desoxy-17-hydroxycorticosterone; 11-Desoxycortisol; 11-Desoxyhydrocortisone; 11-Dioxycortisol; 11-deoxy-17-hydroxy-Corticosterone; 11-deoxy-Cortisol; 11-dioxy-Cortisol; 17,21-Dihydroxy-4-pregnene-3,20-dione; 17,21-Dihydroxyprogesterone; 17,21-dihydroxypregn-4-ene-3,20-dione; 17-Hydroxy-11-deoxycorticosterone; 17alpha-Hydroxycortexone; 20-dione 17,21-Dihydroxypregn-4-ene-3; 4-Pregnene-17alpha,21-diol-3,20-dione; Cortodoxone; Reichstein S; Reichstein's compound S; Reichstein's substance S

# Chemical_IUPAC_Name:
17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

# Chemical_Formula:
C21H30O4

# Chemical_Structure:
tbl_chemical:::HMDB00015_ZOOM.png:::119283128571260145

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00015_THUMB.png:::11928312836578974

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Steroids; Sterols

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
ketone; primary alcohol; tertiary alcohol; alkene

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
346.21442

# Molecular_Weight_Avg:
346.46048

# Smiles_String_isomeric:
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO

# Smiles_String_canonical:
CC12CCC3C(CCC4=CC(=O)CCC34C)C1CCC2(O)C(=O)CO

# KEGG_Compound_ID:
C05488

# BioCyc_ID:
11-DEOXY-CORTISOL

# PubChem_CID:
440707

# PubChem_SID:
3135470; 7978569; 7847; 855521; 10298640; 841445

# OMIM_ID:
201910; 202010

# Metagene_ID:
Not Available

# BiGG_ID:
45914

# Wikipedia_ID:
Cortexolone

# METLIN_ID:
5088

# Ref_ID:
14709852; 15887869; 15755848; 15834216; 1034356; 15985474; 15807871; 6296182; 8081391; 8169562; 15780662; 15780661; 2808702; 1024042; 8890720; 3515819; 1775135

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
152-58-9

# InChI:
InChI=1/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1

# Synthesis_Reference:
Reichstein, T. et al., Helv. Chim. Acta, 1938, 21, 1197; Gallagher, T.F. et al., J.A.C.S., 1949, 71, 3262; Julian, P.L. et al., J.A.C.S., 1950, 72, 5145; Smit, A. et al., Rec. Trav. Chim. (J. R. Neth. Chem. Soc.), 1966, 85, 731; Numazawa, M. et al., J.O.C

# Melting_Point:
215 oC

# Melting_Point_predicted:
134.6 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
0.0152 mg/mL [MEYLAN,WM et al. (1996)]; 0.025 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
3.08 [SANGSTER (1994)]

# LogP_predicted:
2.79 [Predicted by ALOGPS]; 2.4 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00015_msds.html:::1132562189674255972

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C05488.mol:::1132723801234275481

# SDF_File_[Text]:
tbl_chemical:::HMDB00015.sdf:::119283127510569589

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00015.pdb:::119283128197747074

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::00015_Cortexolone.zip:::11824586056999360

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041201_P00_08_BA_assigned.png:::118245860572214836

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041201_P00_08_BA_2DHSQC_128.png:::116630659547436913

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041201_P00_08_BA_2DHSQC_128.zip:::116630659549941688

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041201_P00_08_BA_2DHSQC_128_Assigned.png:::11663065956525452

# Predicted_H_NMR_Spectrum:
tbl_chemical:::11-Deoxycortisol.gif:::113273209887592709

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00015_peaks.txt:::1156309485183526740

# Predicted_C_NMR_Spectrum:
tbl_chemical:::11-Deoxycortisol_C.gif:::1132737657367523084

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00015_peaks.txt:::1156310677207554521

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00015L.png:::117555266484326892; Medium Energy:tbl_ms:::HMDB00015M.png:::11755527050296668; High Energy:tbl_ms:::HMDB00015H.png:::117555272537225719

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane (Predicted from LogP); Cytoplasm (Predicted from Solubility); Cytoplasm; endoplasmic reticulum; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	0.017-178.9	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	3515819
Urine	0.02 (0.0091-0.032)	umol/mmol_creatinine	Adult:>18_yrs_old	Female	Normal	6296182
Blood	< 0.023	umol/L	Adult:>18_yrs_old	Both	Normal	Merck Manual
Blood	0.0039 +/- 0.0004	uM	Adult:>18_yrs_old	Both	Normal	8890720


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Adrenal Cortical Dysfunction (11B-hydroxylase Deficiency); Congenital Adrenal Hyperplasia

# Pathway_Names:
C21-Steroid hormone metabolism;Androgen and estrogen metabolism

# Pathway_Images:
;

# KEGG_Images:
map00140;map00150

# Pathway_Graphs:
;

# Pathway_SBMLs:
;

# Metabolic_Enzyme_1_ID:
5808

# Metabolic_Enzyme_1_Name:
Cytochrome P450 11B2, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
CYPXIB2; P-450Aldo; Aldosterone synthase; ALDOS; Aldosterone-synthesizing enzyme; Steroid 18-hydroxylase; P-450C18

# Metabolic_Enzyme_1_Gene_Name:
CYP11B2

# Metabolic_Enzyme_1_Protein_Sequence:
>Cytochrome P450 11B2, mitochondrial precursor
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN

# Metabolic_Enzyme_1_Number_of_Residues:
503

# Metabolic_Enzyme_1_Molecular_Weight:
57561

# Metabolic_Enzyme_1_Theoretical_pI:
9.78

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_1_Specific_Function:
Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone

# Metabolic_Enzyme_1_Pathway:
map00140  C21-Steroid hormone metabolism;
GENES       HSA: 1584(CYP11B1) 1585(CYP11B2);
            MMU: 13072(Cyp11b2) 223628(LOC223628);
            RNO: 24293(Cyp11b1) 24294(Cyp11b2) 353498(Cyp11b3)

# Metabolic_Enzyme_1_Reaction:
corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.14.15.4;EC 1.14.15.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
181340

# Metabolic_Enzyme_1_SwissProt_ID:
C11B2_HUMAN (P19099)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
CYP11B2

# Metabolic_Enzyme_1_Geneatlas_id:
CYP11B2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2592

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_1_Gene_Sequence:
>1512 bp
ATGGCACTCAGGGCAAAGGCAGAGGTGTGCGTGGCAGCGCCCTGGCTGTGCCTGCAAAGG
GCACGGGCACTGGGCACTAGAGCCGCTCGGGCCCCTAGGACGGTGCTGCCGTTTGAAGCC
ATGCCCCAGCATCCAGGCAACAGGTGGCTGAGGCTGCTGCAGATGTGGAGGGAGCAGGGT
TATGAGCACCTGCACCTGGAGATGCACCAGACCTTCCAGGAGCTGGGGCCCATTTTCAGG
TACAACTTGGGAGGACCACGCATGGTGTGTGTGATGCTGCCGGAGGATGTGGAGAAGCTG
CAACAGGTGGACAGCCTGCATCCCTGCAGGATGATCCTGGAGCCCTGGGTGGCCATCAGA
CAACATCGTGGGCACAAATGTGGCGTGTTCTTGTTGAATGGGCCTGAATGGCGCTTCAAC
CGATTGCGGCTGAACCCAGATGTGCTGTCGCCCAAGGCCGTGCAGAGGTTCCTCCCGATG
GTGGATGCAGTGGCCAGGGACTTTTCCCAGGCCCTGAGGAAGAAGGTGCTGCAGAACGCC
CGGGGGAGCCTGACCCTGGACGTCCAGCCCAGCATCTTCCACTACACCATAGAAGCCAGC
AACTTAGCTCTTTTTGGAGAGCGGCTGGGCCTGGTTGGCCACAGCCCCAGTTCTGCCAGC
CTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCACCGTCCAGCTCATGTTCATG
CCCAGGAGCCTGTCTCGCTGGATCAGCCCCAAGGTGTGGAAGGAGCACTTTGAGGCCTGG
GACTGCATCTTCCAGTACGGTGACAACTGTATCCAGAAAATCTACCAGGAACTGGCCTTC
AACCGCCCTCAACACTACACAGGCATCGTGGCAGAGCTCCTGTTGAAGGCGGAACTGTCA
CTAGAAGCCATCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCGTGGACACGACAGCG
TTTCCGTTGCTGATGACGCTCTTTGAGCTGGCTCGGAACCCCGACGTGCAGCAGATCCTG
CGCAAGGAGAGCCTGGCCGCCGCAGCCAGCATCAGTGAACATCCCCAGAAGGCAACCACC
GAGCTGCCCTTGCTGCGGGCGGCCCTCAAGGAGACCTTGAGGCTCTACCCTGTGGGTCTG
TTTTTGGAGCGAGTGGTGAGCTCAGACTTGGTGCTTCAGAACTACCACATCCCAGCTGGG
ACATTGGTACAGGTTTTCCTCTACTCGCTGGGTCGCAATGCCGCCTTGTTCCCGAGGCCT
GAGCGGTATAATCCCCAGCGCTGGCTAGACATCAGGGGCTCCGGCAGGAACTTGCACCAC
GTGCCCTTTGGCTTTGGCATGCGCCAGTGCCTCGGGCGGCGCCTGGCAGAGGCAGAGATG
CTGCTGCTGCTGCACCACGTGCTGAAGCGCTTCCTGGTGGAGACACTAACTCAAGAGGAC
ATAAAGATGGTCTACAGCTTCATATTGAGGCCTGGCACGTCCCCCCTCCTCACTTTCAGA
GCGATTAACTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M32881

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_1_Locus:
8q21-q22

# Metabolic_Enzyme_1_SNPs:
rs4545; rs4544; rs6441; rs4537; rs4539; rs5312; rs6438; rs4536; rs4543; rs4538; rs5310; rs5313; rs5281; rs4546; rs3802230; rs3839864; rs3097; rs3802228; rs3201271; rs6431; rs6435; rs7461740; rs6397; rs6432; rs6429; rs11781816; rs6421; rs10107682; rs10090630; rs4072020; rs6399; rs10096239; rs6396; rs10099658; rs4736320; rs6433; rs7836572; rs13276226; rs5307; rs10099052; rs6418; rs6434; rs6416; rs10086846; rs12679242; rs6414; rs10110732; rs6415; rs11779229; rs6394; rs5306; rs6413; rs10090037; rs7463212; rs1799998; rs6471583; rs11781082; rs10087214; rs6992689; rs11991278; rs6440; rs12542987; rs5305; rs28931609; rs5315; rs5317; rs28930074; rs9297975; rs3201269; rs33921450; rs7463238; rs35574522; rs28390200; rs28491316; rs3201272; rs33936656; rs13257266; rs13268153; rs28531895; rs33911914; rs28361356; rs35733998; rs5895735; rs35490512; rs28526467; rs36018151; rs34144193; rs6436; rs28366703; rs13257680; rs1574565; rs5314; rs35909170; rs28394055; rs13263682; rs28615142; rs28497862; rs13252628; rs13257267; rs28659182; rs13268025; rs5895734; rs10956996; rs34951350; rs7463148; rs10623281; rs13254375; rs34884498; rs7464883; rs1800534; rs10096393; rs10108843; rs11775009; rs12546357; rs13267320; rs35431302; rs4379428; rs4736317; rs4736318; rs4736319; rs4736355; rs4736356; rs4736357; rs4736358; rs4736359; rs4736360; rs6471580; rs6471581; rs6471586; rs6651273; rs6981918; rs6987382; rs7004863; rs7011830; rs7011889; rs7011901; rs7016924; rs7460125; rs7819943; rs7820667; rs7821838; rs7824229; rs7828967; rs7831617; rs7844961; rs9643358

# Metabolic_Enzyme_1_General_References:
2592361; 2256920; 1594605; 1346492; 8439335; 9177280; 9625333; 9814506; 9931115; 10391209; 10391210; 11238478; 12788848

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5737

# Metabolic_Enzyme_2_Name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II

# Metabolic_Enzyme_2_Synonyms:
3- beta-HSD II[Includes: 3-beta-hydroxy-Delta(5-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta-isomerase; Delta- 5-3-ketosteroid isomerase]

# Metabolic_Enzyme_2_Gene_Name:
HSD3B2

# Metabolic_Enzyme_2_Protein_Sequence:
>3 betahydroxysteroid dehydrogenase/Delta 5>4isomerase type II
MGWSCLVTGAGGLLGQRIVRLLVEEKELKEIRALDKAFRPELREEFSKLQNRTKLTVLEG
DILDEPFLKR
ACQDVSVVIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVF
IYTSSIEVAGPNSYKEIIQNG
HEEEPLENTWPTPYPYSKKLAEKAVLAANGWNLKNGDT
LYTCALRPTYIYGEGGPFLSASINEALNNNGI
LSSVGKFSTVNPVYVGNVAWAHILALR
ALRDPKKAPSVRGQFYYISDDTPHQSYDNLNYILSKEFGLRLD
SRWSLPLTLMYWIGFL
LEVVSFLLSPIYSYQPPFNRHTVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQ
KTVEW
VGSLVDRHKETLKSKTQ

# Metabolic_Enzyme_2_Number_of_Residues:
372

# Metabolic_Enzyme_2_Molecular_Weight:
42053

# Metabolic_Enzyme_2_Theoretical_pI:
8.17

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, transposing C=C bonds
Function:  steroid delta-isomerase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  3-beta-hydroxy-delta5-steroid dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_2_Specific_Function:
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids

# Metabolic_Enzyme_2_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_2_Reaction:
A 3-oxo-delta5-steroid = a 3-oxo-delta4-steroid

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01073:3Beta_HSD

# Metabolic_Enzyme_2_Signals:
1-15

# Metabolic_Enzyme_2_Transmembrane_Regions:
287-307

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.1.145;EC 5.3.3.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
184401

# Metabolic_Enzyme_2_SwissProt_ID:
3BHS2_HUMAN (P26439)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
HSD3B2

# Metabolic_Enzyme_2_Geneatlas_id:
HSD3B2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:5218

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein. Mitochondrion; mitochondrial membrane; single-pass membrane protein

# Metabolic_Enzyme_2_Gene_Sequence:
>1119 bp

ATGGGCTGGAGCTGCCTTGTGACAGGAGCAGGAGGGCTTCTGGGTCAGAGGATCGTCCG
CCTGTTGGTGG
AAGAGAAGGAACTGAAGGAGATCAGGGCCTTGGACAAGGCCTTCAGAC
CAGAATTGAGAGAGGAATTTTC
TAAGCTCCAGAACAGGACCAAGCTGACTGTACTTGAA
GGAGACATTCTGGATGAGCCATTCCTGAAAAGA
GCCTGCCAGGACGTCTCGGTCGTCAT
CCACACCGCCTGTATCATTGATGTCTTTGGTGTCACTCACAGAG
AGTCCATCATGAATG
TCAATGTGAAAGGTACCCAGCTACTGTTGGAGGCCTGTGTCCAAGCCAGTGTGCC
AGTC
TTCATCTACACCAGTAGCATAGAGGTAGCCGGGCCCAACTCCTACAAGGAAATCATCCAG
AACGGC
CACGAAGAAGAGCCTCTGGAAAACACATGGCCCACTCCATACCCGTACAGCAA
AAAGCTTGCTGAGAAGG
CTGTGCTGGCGGCTAATGGGTGGAATCTAAAAAATGGTGATA
CCTTGTACACTTGTGCGTTAAGACCCAC
ATATATCTATGGGGAAGGAGGCCCATTCCTT
TCTGCCAGTATAAATGAGGCCCTGAACAACAATGGGATC
CTGTCAAGTGTTGGAAAGTT
CTCTACAGTCAACCCAGTCTATGTTGGCAACGTGGCCTGGGCCCACATTC
TGGCCTTGA
GGGCTCTGCGGGACCCCAAGAAGGCCCCAAGTGTCCGAGGTCAATTCTATTACATCTCAG
A
TGACACGCCTCACCAAAGCTATGATAACCTTAATTACATCCTGAGCAAAGAGTTTGGC
CTCCGCCTTGAT
TCCAGATGGAGCCTTCCTTTAACCCTGATGTACTGGATTGGCTTCCT
GCTGGAAGTAGTGAGCTTCCTAC
TCAGCCCAATTTACTCCTATCAACCCCCCTTCAACC
GCCACACAGTCACATTATCAAATAGTGTGTTCAC
CTTCTCTTACAAGAAGGCTCAGCGA
GATCTGGCGTATAAGCCACTCTACAGCTGGGAGGAAGCCAAGCAG
AAAACCGTGGAGTG
GGTTGGTTCCCTTGTGGACCGGCACAAGGAGACCCTGAAGTCCAAGACTCAGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M67466

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_2_Locus:
1p13.1

# Metabolic_Enzyme_2_SNPs:
rs4986954; rs6211; rs35887327; rs6207; rs33926546; rs34412477; rs33932258; rs1819698; rs1361530; rs9282704; rs6208; rs6210; rs9282703; rs3753258; rs12411115; rs2854961; rs33920337; rs17023577; rs12044792; rs2854964; rs10923817; rs3765948; rs12411080; rs2854963; rs2793133; rs7411891; rs2854962; rs2793132; rs6676988; rs4659174; rs12062744; rs33952871; rs33963971; rs4659175; rs35983269; rs34492690; rs34177617; rs35954381; rs35344469; rs35569514; rs9282705; rs28943871; rs35613222; rs28934880; rs35486059; rs34562248; rs714748; rs10591825; rs10616581; rs34234813; rs12741109; rs3057393; rs35081017; rs3820030; rs6692175; rs10616582; rs12742063; rs12404035; rs12741125; rs36021225; rs36022499; rs5777392; rs12723698; rs35507723; rs35448442; rs35847875; rs34282330; rs10754396; rs10923815; rs10923819; rs10923820; rs11579951; rs12022215; rs12403392; rs12404131; rs12405488; rs1341018; rs17023564; rs2185556; rs2185557; rs6661603; rs947129

# Metabolic_Enzyme_2_General_References:
1944309; 1741954; 8316254; 7833923; 8126127; 7962268; 8185809; 8060486; 7893703; 7633426; 7633460; 7608265; 9719627; 10599696; 10651755; 10843183; 12050213

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5809

# Metabolic_Enzyme_3_Name:
Cytochrome P450 21

# Metabolic_Enzyme_3_Synonyms:
Cytochrome P450 XXI; Steroid 21- hydroxylase; 21-OHase; P450-C21; P-450c21; P450-C21B

# Metabolic_Enzyme_3_Gene_Name:
CYP21A2

# Metabolic_Enzyme_3_Protein_Sequence:
>Cytochrome P450 21
MLLLGLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYR
LHLGLQDVVV
LNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDLSLGDYSLLWKAH
KKLTRSALLLGIRDSMEPVVE
QLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFG
DKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVD
VIPFLRFFPNPGLRRLKQAIEKRDHIV
EMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGH
VHMAAVDLLIGGTETT
ANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIA
EVLRL
RPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKN
SRALA
FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQ
PFQVRLQPRGMGAHSP
GQNQ

# Metabolic_Enzyme_3_Number_of_Residues:
494

# Metabolic_Enzyme_3_Molecular_Weight:
55888

# Metabolic_Enzyme_3_Theoretical_pI:
7.90

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_3_Specific_Function:
Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids

# Metabolic_Enzyme_3_Pathway:
map00140  C21-Steroid hormone metabolism

# Metabolic_Enzyme_3_Reaction:
a steroid + AH2 + O2 = a 21-hydroxysteroid + A + H2O

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_3_Signals:
1-15

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.14.99.10

# Metabolic_Enzyme_3_GenBank_ID_Protein:
181290

# Metabolic_Enzyme_3_SwissProt_ID:
CP21A_HUMAN (P08686)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
CYP21A2

# Metabolic_Enzyme_3_Geneatlas_id:
CYP21A2

# Metabolic_Enzyme_3_hgnc_id:
HGNC:2600

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein

# Metabolic_Enzyme_3_Gene_Sequence:
>102 bp

CGCATGAGAGCCCAGCCCGGCACCCCTGTGGCCATTGAGGAGGAATTCTCTCTCCTCAC
CTGCAGCATCA
TCTGTTACCTCACCTTCGGAGACAAGATCAAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M19711

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_3_Locus:
6p21.3

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
3487786; 3486422; 3038528; 1406709; 3871526; 3497399; 1864962; 8081391; 3257825; 2303461; 1937474; 2072928; 1644925; 1406699; 1496017; 8478006; 7749410; 9067760; 9187661; 8989258; 9580109; 9497336; 10094562; 10408778; 10408786; 10051010; 10391209; 12788866; 12915679

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5683

# Metabolic_Enzyme_4_Name:
Cytochrome P450 11B1, mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
CYPXIB1; P450C11; P-450c11; Steroid 11-beta-hydroxylase

# Metabolic_Enzyme_4_Gene_Name:
CYP11B1

# Metabolic_Enzyme_4_Protein_Sequence:
>Cytochrome P450 11B1, mitochondrial precursor
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPQRPGNRWLRLLQIWREQG
YEDLHLEVHQ
TFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAY
RQHRGHKCGVFLLNGPEWRFN
RLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQ
NARGSLTLDVQPSIFHYTIEASNLALFGERLG
LVGHSPSSASLNFLHALEVMFKSTVQL
MFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF
SRPQQYTSIVAELLLN
AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAAS
ISEHP
QKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVRVFLYSLGRNPA
LFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE
TLTQEDIKMVYSFILR
PSMCPLLTFRAIN

# Metabolic_Enzyme_4_Number_of_Residues:
503

# Metabolic_Enzyme_4_Molecular_Weight:
57530

# Metabolic_Enzyme_4_Theoretical_pI:
9.42

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_4_Specific_Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB

# Metabolic_Enzyme_4_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_4_Reaction:
a steroid + reduced adrenal ferredoxin + O2 = an 11beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_4_Signals:
1-23

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.14.15.4

# Metabolic_Enzyme_4_GenBank_ID_Protein:
181333

# Metabolic_Enzyme_4_SwissProt_ID:
C11B1_HUMAN (P15538)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CYP11B1

# Metabolic_Enzyme_4_Geneatlas_id:
CYP11B1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:2591

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_4_Gene_Sequence:
>1512 bp

ATGGCACTCAGGGCAAAGGCAGAGGTGTGCATGGCAGTGCCCTGGCTGTCCCTGCAAAG
GGCACAGGCAC
TGGGCACGAGAGCCGCCCGGGTCCCCAGGACAGTGCTGCCCTTTGAAG
CCATGCCCCGGCGTCCAGGCAA
CAGGTGGCTGAGGCTGCTGCAGATCTGGAGGGAGCAG
GGTTATGAGGACCTGCACCTGGAAGTACACCAG
ACCTTCCAGGAACTGGGGCCCATTTT
CAGGTACGATTTGGGAGGAGCAGGCATGGTGTGTGTGATGCTGC
CGGAGGACGTGGAGA
AGCTGCAACAGGTGGACAGCCTGCATCCCCACAGGATGAGCCTGGAGCCCTGGGT
GGCC
TACAGACAACATCGTGGGCACAAATGTGGCGTGTTCTTGCTGAATGGGCCTGAATGGCGC
TTCAAC
CGATTGCGGCTGAATCCAGAAGTGCTGTCGCCCAACGCTGTGCAGAGGTTCCT
CCCGATGGTGGATGCAG
TGGCCAGGGACTTCTCCCAGGCCCTGAAGAAGAAGGTGCTGC
AGAACGCCCGGGGGAGCCTGACCCTGGA
CGTCCAGCCCAGCATCTTCCACTACACCATA
GAAGCCAGCAACTTGGCTCTTTTTGGAGAGCGGCTGGGC
CTGGTTGGCCACAGCCCCAG
TTCTGCCAGCCTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCA
CCGTCCAGC
TCATGTTCATGCCCAGGAGCCTGTCTCGCTGGACCAGCCCCAAGGTGTGGAAGGAGCACT
T
TGAGGCCTGGGACTGCATCTTCCAGTACGGCGACAACTGTATCCAGAAAATCTATCAG
GAACTGGCCTTC
AGCCGCCCTCAACAGTACACCAGCATCGTGGCGGAGCTCCTGTTGAA
TGCGGAACTGTCGCCAGATGCCA
TCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCG
TGGACACGACGGTGTTTCCCTTGCTGATGACGCT
CTTTGAGCTGGCTCGGAACCCCAAC
GTGCAGCAGGCCCTGCGCCAGGAGAGCCTGGCCGCCGCAGCCAGC
ATCAGTGAACATCC
CCAGAAGGCAACCACCGAGCTGCCCTTGCTGCGTGCGGCCCTCAAGGAGACCTTGC
GGC
TCTACCCTGTGGGTCTGTTTCTGGAGCGAGTGGCGAGCTCAGACTTGGTGCTTCAGAACT
ACCACAT
CCCAGCTGGGACATTGGTGCGCGTGTTCCTCTACTCTCTGGGTCGCAACCCC
GCCTTGTTCCCGAGGCCT
GAGCGCTATAACCCCCAGCGCTGGCTAGACATCAGGGGCTC
CGGCAGGAACTTCTACCACGTGCCCTTTG
GCTTTGGCATGCGCCAGTGCCTTGGGCGGC
GCCTGGCAGAGGCAGAGATGCTGCTGCTGCTGCACCATGT
GCTGAAACACCTCCAGGTG
GAGACACTAACCCAAGAGGACATAAAGATGGTCTACAGCTTCATATTGAGG
CCCAGCAT
GTGCCCCCTCCTCACCTTCAGAGCCATCAACTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M32879

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_4_Locus:
8q21

# Metabolic_Enzyme_4_SNPs:
rs4541; rs4534; rs5288; rs5294; rs6405; rs34620645; rs6410; rs5283; rs5290; rs6403; rs6419; rs34570566; rs5316; rs5284; rs5299; rs5301; rs7003319; rs5304; rs1134096; rs5303; rs1134095; rs5017238; rs5297; rs4736312; rs5300; rs3802229; rs6389; rs9657021; rs4310186; rs6388; rs7822986; rs6471570; rs6387; rs4535; rs4736315; rs10956991; rs5295; rs6393; rs7814006; rs7814020; rs7818826; rs4609179; rs7818953; rs11775687; rs6390; rs6398; rs10105643; rs6400; rs6392; rs12674916; rs7833415; rs6411; rs6391; rs12542799; rs6402; rs6395; rs6422; rs6409; rs5280; rs4736346; rs10093618; rs4736311; rs4471016; rs4313136; rs5292; rs28934586; rs5287; rs5282; rs4998901; rs5291; rs4998896; rs6407; rs4998898; rs4998902; rs4998900; rs4998899; rs4998903; rs4998897; rs9657022; rs5296; rs4998895; rs1137481; rs1137484; rs5302; rs35673190; rs5017237; rs1137480; rs1137485; rs12543598; rs5298; rs34274727; rs1137488; rs5017240; rs5027479; rs1137486; rs1137483; rs5027480; rs5017239; rs1137487; rs5027478; rs4998894; rs9657020; rs4999335; rs4236887; rs5286; rs13250178; rs4999334; rs35378570; rs28551743; rs36004897; rs5895733; rs34698173; rs12114482; rs28418310; rs10098023; rs4464947; rs4548164; rs4581033; rs4736308; rs4736309; rs4736310; rs4736349; rs4736350; rs6995180; rs7005638; rs7016088; rs7016594

# Metabolic_Enzyme_4_General_References:
2592361; 2401360; 7903314; 3499608; 1741400; 2022736; 9302260; 10599751; 10391209; 10391210

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5738

# Metabolic_Enzyme_5_Name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I

# Metabolic_Enzyme_5_Synonyms:
3- beta-HSD I; Trophoblast antigen FDO161G[Includes: 3-beta-hydroxy- Delta(5-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta- isomerase; Delta-5-3-ketosteroid isomerase]

# Metabolic_Enzyme_5_Gene_Name:
HSD3B1

# Metabolic_Enzyme_5_Protein_Sequence:
>3 betahydroxysteroid dehydrogenase/Delta 5>4isomerase type I
MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELREEFSKLQNKTKLTVLE
GDILDEPFLK
RACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPV
FIYTSSIEVAGPNSYKEIIQN
GHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGG
TLYTCALRPMYIYGEGSRFLSASINEALNNNG
ILSSVGKFSTVNPVYVGNVAWAHILAL
RALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRL
DSRWSFPLSLMYWIGF
LLEIVSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAK
QKTVE
WVGSLVDRHKETLKSKTQ

# Metabolic_Enzyme_5_Number_of_Residues:
373

# Metabolic_Enzyme_5_Molecular_Weight:
42252

# Metabolic_Enzyme_5_Theoretical_pI:
8.98

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, transposing C=C bonds
Function:  steroid delta-isomerase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  3-beta-hydroxy-delta5-steroid dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_5_Specific_Function:
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids

# Metabolic_Enzyme_5_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_5_Reaction:
A 3-oxo-delta5-steroid = a 3-oxo-delta4-steroid

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01073:3Beta_HSD

# Metabolic_Enzyme_5_Signals:
1-13

# Metabolic_Enzyme_5_Transmembrane_Regions:
288-308

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.1.1.145;EC 5.3.3.1

# Metabolic_Enzyme_5_GenBank_ID_Protein:
306889

# Metabolic_Enzyme_5_SwissProt_ID:
3BHS1_HUMAN (P14060)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
HSD3B1

# Metabolic_Enzyme_5_Geneatlas_id:
HSD3B1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:5217

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein. Mitochondrion; mitochondrial membrane; single-pass membrane protein

# Metabolic_Enzyme_5_Gene_Sequence:
>1122 bp

ATGACGGGCTGGAGCTGCCTTGTGACAGGAGCAGGAGGGTTTCTGGGACAGAGGATCAT
CCGCCTCTTGG
TGAAGGAGAAGGAGCTGAAGGAGATCAGGGTCTTGGACAAGGCCTTCG
GACCAGAATTGAGAGAGGAATT
TTCTAAACTCCAGAACAAGACCAAGCTGACAGTGCTG
GAAGGAGACATTCTGGATGAGCCATTCCTGAAG
AGAGCCTGCCAGGACGTCTCGGTCAT
CATCCACACCGCCTGTATCATTGATGTCTTCGGTGTCACTCACA
GAGAGTCTATCATGA
ATGTCAATGTGAAAGGTACCCAGCTCCTGTTAGAGGCCTGTGTCCAAGCTAGTGT
GCCA
GTCTTCATCTACACCAGTAGCATAGAGGTAGCCGGGCCCAACTCCTACAAGGAAATCATC
CAGAAT
GGCCATGAAGAAGAGCCTCTGGAAAACACATGGCCCGCTCCATACCCACACAG
CAAAAAGCTTGCTGAGA
AGGCTGTACTGGCGGCTAACGGGTGGAATCTGAAAAACGGCG
GCACCCTGTACACTTGTGCCTTACGACC
CATGTATATCTATGGGGAAGGAAGCCGATTC
CTTTCTGCTAGTATAAACGAGGCCCTGAACAACAATGGG
ATCCTGTCAAGTGTTGGAAA
GTTCTCCACTGTTAACCCAGTCTATGTTGGCAATGTGGCCTGGGCCCACA
TTCTGGCCT
TGAGGGCCCTGCAGGACCCCAAGAAGGCCCCAAGCATCCGAGGACAGTTCTACTATATCT
C
AGATGACACGCCTCACCAAAGCTATGATAACCTTAATTACACCCTGAGCAAAGAGTTC
GGCCTCCGCCTT
GATTCCAGATGGAGCTTTCCTTTATCCCTGATGTATTGGATTGGCTT
CCTGCTGGAAATAGTGAGCTTCC
TACTCAGGCCAATTTACACCTATCGACCGCCCTTCA
ACCGCCACATAGTCACATTGTCAAATAGCGTATT
CACCTTCTCTTATAAGAAGGCTCAG
CGAGATCTGGCGTATAAGCCACTCTACAGCTGGGAGGAAGCCAAG
CAGAAAACGGTGGA
GTGGGTTGGTTCCCTTGTGGACCGGCACAAGGAGACCCTGAAGTCCAAGACTCAGT
GA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M27137

# Metabolic_Enzyme_5_Chromosome_Location:
Not Available

# Metabolic_Enzyme_5_Locus:
Not Available

# Metabolic_Enzyme_5_SNPs:
Not Available

# Metabolic_Enzyme_5_General_References:
2779585; 2139411; 2082186; 2243100; 1920284; 1401999; 10391209

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5675

# Metabolic_Enzyme_6_Name:
Tryptophan 2,3-dioxygenase

# Metabolic_Enzyme_6_Synonyms:
TO; Tryptophan pyrrolase; Tryptophanase; Tryptophan oxygenase; Tryptamin 2,3-dioxygenase; TRPO

# Metabolic_Enzyme_6_Gene_Name:
TDO2

# Metabolic_Enzyme_6_Protein_Sequence:
>Tryptophan 2,3dioxygenase
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSE
TKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSV
ILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHY
RDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIR
IQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD

# Metabolic_Enzyme_6_Number_of_Residues:
406

# Metabolic_Enzyme_6_Molecular_Weight:
47872

# Metabolic_Enzyme_6_Theoretical_pI:
6.93

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
Function:  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Function:  tryptophan 2,3-dioxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  indolalkylamine metabolism
Process:  tryptophan metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin

# Metabolic_Enzyme_6_Pathway:
map00380  Tryptophan metabolism

# Metabolic_Enzyme_6_Reaction:
L-tryptophan + O2 = L-formylkynurenine

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF03301:Trp_dioxygenase

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.13.11.11

# Metabolic_Enzyme_6_GenBank_ID_Protein:
993046

# Metabolic_Enzyme_6_SwissProt_ID:
T23O_HUMAN (P48775)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
TDO2

# Metabolic_Enzyme_6_Geneatlas_id:
TDO2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:11708

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>1221 bp
ATGAGTGGGTGCCCATTTTTAGGAAACAACTTTGGATATACTTTTAAAAAACTCCCCGTA
GAAGGCAGCGAAGAAGACAAATCACAAACTGGTGTGAATAGAGCCAGCAAAGGAGGTCTT
ATCTATGGGAACTACCTGCATTTGGAAAAAGTTTTGAATGCACAAGAACTGCAAAGTGAA
ACAAAAGGAAATAAAATCCATGATGAACATCTTTTTATCATAACTCATCAAGCTTATGAA
CTCTGGTTTAAGCAAATCCTCTGGGAGTTGGATTCTGTTCGAGAGATCTTTCAGAATGGC
CATGTCAGAGATGAAAGGAACATGCTTAAGGTTGTTTCTCGGATGCACCGAGTGTCAGTG
ATCCTGAAACTGCTGGTGCAGCAGTTTTCCATTCTGGAGACGATGACAGCCTTGGACTTC
AATGACTTCAGAGAGTACTTATCTCCAGCATCAGGCTTCCAGAGTTTGCAATTCCGACTA
TTAGAAAACAAGATAGGTGTTCTTCAGAACATGAGAGTCCCTTATAACAGAAGACATTAT
CGTGATAACTTCAAAGGAGAAGAAAATGAACTGCTACTTAAATCTGAGCAGGAAAAGACA
CTTCTGGAATTAGTGGAGGCATGGCTGGAAAGAACTCCAGGTTTAGAGCCACATGGATTT
AACTTCTGGGGAAAGCTTGAAAAAAATATCACCAGAGGCCTGGAAGAGGAATTCATAAGG
ATTCAGGCTAAAGAAGAGTCTGAAGAAAAAGAGGAACAGGTGGCTGAATTTCAGAAGCAA
AAAGAGGTGCTACTGTCCTTATTTGATGAGAAACGTCATGAACATCTCCTTAGTAAAGGT
GAAAGACGGCTGTCATACAGAGCACTTCAGGGAGCATTGATGATATATTTTTACAGGGAA
GAGCCTAGGTTCCAGGTGCCTTTTCAGTTGCTGACTTCTCTTATGGACATAGATTCACTG
ATGACCAAATGGAGATATAACCATGTGTGCATGGTGCACAGAATGCTGGGCAGCAAAGCT
GGCACCGGTGGTTCCTCAGGCTATCACTACCTGCGATCAACTGTGAGTGATAGGTACAAG
GTATTTGTAGATTTATTTAATCTTTCAACATACCTGATTCCCCGACACTGGATACCGAAG
ATGAACCCAACCATTCACAAATTTCTATATACAGCAGAATACTGTGATAGCTCCTACTTC
AGCAGTGATGAATCAGATTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
U32989

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_6_Locus:
4q31-q32

# Metabolic_Enzyme_6_SNPs:
rs2271537; rs2878125; rs6830072; rs7674417; rs11723579; rs10020753; rs6856558; rs2137778; rs2292536; rs2292537; rs6536122; rs12646333; rs6830800; rs6817205; rs2271538; rs2048652; rs13128945; rs10517626; rs12502494; rs9307937; rs16998970; rs3796552; rs13107510; rs10034841; rs9307936; rs10018290; rs6828277; rs17033777; rs3839139; rs12510023; rs3796551; rs3839140; rs13125676; rs13434811; rs13152449; rs13107055; rs3755908; rs10857287; rs11935082; rs3775085; rs17033763; rs3755909; rs17379913; rs3775086; rs3836580; rs6856687; rs11541501; rs28601721; rs1399049; rs34837968; rs34847339; rs34167914; rs10595404; rs35761138; rs13148802; rs34133854; rs34184093; rs28369464; rs10598060; rs35631700; rs28683807; rs6810476; rs35929431; rs28446368; rs13128538; rs34104412; rs17033790; rs3965794; rs1399043; rs13435334; rs35493540; rs11273681; rs28452752; rs13106862; rs11732472; rs3796554; rs28420292; rs28538165; rs34051837; rs13101532; rs34991756; rs3796553; rs13152593; rs3755910; rs7697993; rs3836581; rs10163; rs10517627; rs17033799; rs17379906; rs3755907; rs3775084; rs573; rs6536119; rs6839640; rs6856354; rs9044

# Metabolic_Enzyme_6_General_References:
8666386

# Metabolic_Enzyme_6_References:
4050454; 6103800

# Macromolecular_Interacting_Partner_1_ID:
7197

# Macromolecular_Interacting_Partner_1_Name:
Corticotropin-lipotropin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Pro-opiomelanocortin; POMC[Contains: NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin]

# Macromolecular_Interacting_Partner_1_Gene_Name:
POMC

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Corticotropinlipotropin precursor
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
267

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
29424

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Beta-endorphin and Met-enkephalin are endogenous opiates

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00976:ACTH_domain;
PF08384:NPP;
PF08035:Op_neuropeptide

# Macromolecular_Interacting_Partner_1_Signals:
1-26

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
190188

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
COLI_HUMAN (P01189)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
POMC

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
POMC

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9201

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>789 bp
TGCAGCCGCTCGGGGGCCCTGTTGCTGGCCTTGCTGCTTCAGGCCTCCATGGAAGTGCGT
GGCTGGTGCCTGGAGAGCAGCCAGTGTCAGGACCTCACCACGGAAAGCAACCTGCTGGAG
TGCATCCGGGCCTGCAAGCCCGACCTCTCGGCCGAGACTCCCATGTTCCCGGGAAATGGC
GACGAGCAGCCTCTGACCGAGAACCCCCGGAAGTACGTCATGGGCCACTTCCGCTGGGAC
CGATTCGGCCGCCGCAACAGCAGCAGCAGCGGCAGCAGCGGCGCAGGGCAGAAGCGCGAG
GACGTCTCAGCGGGCGAAGACTGCGGCCCGCTGCCTGAGGGCGGCCCCGAGCCCCGCAGC
GATGGTGCCAAGCCGGGCCCGCGCGAGGGCAAGCGCTCCTACTCCATGGAGCACTTCCGC
TGGGGCAAGCCGGTGGGCAAGAAGCGGCGCCCAGTGAAGGTGTACCCTAACGGCGCCGAG
GACGAGTCGGCCGAGGCCTTCCCCCTGGAGTTCAAGAGGGAGCTGACTGGCCAGCGACTC
CGGGAGGGAGATGGCCCCGACGGCCCTGCCGATGACGGCGCAGGGGCCCAGGCCGACCTG
GAGCACAGCCTGCTGGTGGCGGCCGAGAAGAAGGACGAGGGCCCCTACAGGATGGAGCAC
TTCCGCTGGGGCAGCCCGCCCAAGGACAAGCGCTACGGCGGTTTCATGACCTCCGAGAAG
AGCCAGACGCCCCTGGTGACGCTGTTCAAAAACGCCATCATCAAGAACGCCTACAAGAAG
GGCGAGTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M38297

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_1_Locus:
2p23.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs28932472; rs8192606; rs28932471; rs35254395; rs8192605; rs28930368; rs2071345; rs34650613; rs1042571; rs11679531; rs6713532; rs7565877; rs6713396; rs12473543; rs6756695; rs6545975; rs6756566; rs28932474; rs28932476; rs28932475; rs28932473; rs10654394; rs28932470; rs3039380; rs35411223; rs35023083; rs33950052; rs7591899; rs15461; rs2071344; rs13388660; rs9973478; rs11353932; rs13404336; rs7565427; rs34619618; rs8192607; rs35639116; rs34526166; rs10188864; rs10195561; rs11892647; rs12472851; rs13418937; rs17046887; rs17046891; rs1866146; rs2071343; rs2118404; rs2164808; rs3769671; rs3795955; rs3820935; rs6545976; rs6719226; rs6734859; rs7589318; rs7605927; rs934778

# Macromolecular_Interacting_Partner_1_General_References:
6274691; 6299668; 6314261; 3606677; 6254047; 6945581; 6267033; 6272808; 4352834; 4334191; 4338630; 4347148; 1264228; 195688; 2424570; 2839146; 7828531; 9768693; 10193875; 11244459

# Macromolecular_Interacting_Partner_1_References:
12571170; 1322161; 1330379; 1339134

# Macromolecular_Interacting_Partner_2_ID:
7546

# Macromolecular_Interacting_Partner_2_Name:
Prolactin precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
PRL

# Macromolecular_Interacting_Partner_2_Gene_Name:
PRL

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Prolactin precursor
MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN
EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG
LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
227

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
25876

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.99

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Prolactin acts primarily on the mammary gland by promoting lactation

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_2_Signals:
1-28

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
34211

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
PRL_HUMAN (P01236)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
PRL

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
PRL

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:9445

# Macromolecular_Interacting_Partner_2_PDB_ID:
1RW5

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>684 bp
ATGAACATCAAAGGATCGCCATGGAAAGGGTCCCTCCTGCTGCTGCTGGTGTCAAACCTG
CTGCTGTGCCAGAGCGTGGCCCCCTTGCCCATCTGTCCCGGCGGGGCTGCCCGATGCCAG
GTGACCCTTCGAGACCTGTTTGACCGCGCCGTCGTCCTGTCCCACTACATCCATAACCTC
TCCTCAGAAATGTTCAGCGAATTCGATAAACGGTATACCCATGGCCGGGGGTTCATTACC
AAGGCCATCAACAGCTGCCACACTTCTTCCCTTGCCACCCCCGAAGACAAGGAGCAAGCC
CAACAGATGAATCAAAAAGACTTTCTGAGCCTGATAGTCAGCATATTGCGATCCTGGAAT
GAGCCTCTGTATCATCTGGTCACGGAAGTACGTGGTATGCAAGAAGCCCCGGAGGCTATC
CTATCCAAAGCTGTAGAGATTGAGGAGCAAACCAAACGGCTTCTAGAGGGCATGGAGCTG
ATAGTCAGCCAGGTTCATCCTGAAACCAAAGAAAATGAGATCTACCCTGTCTGGTCGGGA
CTTCCATCCCTGCAGATGGCTGATGAAGAGTCTCGCCTTTCTGCTTATTATAACCTGCTC
CACTGCCTACGCAGGGATTCACATAAAATCGACAATTATCTCAAGCTCCTGAAGTGCCGA
ATCATCCACAACAACAACTGCTAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00566

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_2_Locus:
6p22.2-p21.3

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
6260780; 6325171; 2050267; 6146607; 9266104; 925136; 1126929

# Macromolecular_Interacting_Partner_2_References:
9547720

# Macromolecular_Interacting_Partner_3_ID:
7297

# Macromolecular_Interacting_Partner_3_Name:
Glucocorticoid receptor

# Macromolecular_Interacting_Partner_3_Synonyms:
GR

# Macromolecular_Interacting_Partner_3_Gene_Name:
NR3C1

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Glucocorticoid receptor
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
777

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
85660

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.31

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  transcription factor activity
Function:  steroid binding
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  glucocorticoid receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Receptor for glucocorticoids (GC). Has a dual mode of action:as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF02155:GCR;
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
31680

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
GCR_HUMAN (P04150)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
NR3C1

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
NR3C1

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:7978

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>2334 bp
ATGGACTCCAAAGAATCATTAACTCCTGGTAGAGAAGAAAACCCCAGCAGTGTGCTTGCT
CAGGAGAGGGGAGATGTGATGGACTTCTATAAAACCCTAAGAGGAGGAGCTACTGTGAAG
GTTTCTGCGTCTTCACCCTCACTGGCTGTCGCTTCTCAATCAGACTCCAAGCAGCGAAGA
CTTTTGGTTGATTTTCCAAAAGGCTCAGTAAGCAATGCGCAGCAGCCAGATCTGTCCAAA
GCAGTTTCACTCTCAATGGGACTGTATATGGGAGAGACAGAAACAAAAGTGATGGGAAAT
GACCTGGGATTCCCACAGCAGGGCCAAATCAGCCTTTCCTCGGGGGAAACAGACTTAAAG
CTTTTGGAAGAAAGCATTGCAAACCTCAATAGGTCGACCAGTGTTCCAGAGAACCCCAAG
AGTTCAGCATCCACTGCTGTGTCTGCTGCCCCCACAGAGAAGGAGTTTCCAAAAACTCAC
TCTGATGTATCTTCAGAACAGCAACATTTGAAGGGCCAGACTGGCACCAACGGTGGCAAT
GTGAAATTGTATACCACAGACCAAAGCACCTTTGACATTTTGCAGGATTTGGAGTTTTCT
TCTGGGTCCCCAGGTAAAGAGACGAATGAGAGTCCTTGGAGATCAGACCTGTTGATAGAT
GAAAACTGTTTGCTTTCTCCTCTGGCGGGAGAAGACGATTCATTCCTTTTGGAAGGAAAC
TCGAATGAGGACTGCAAGCCTCTCATTTTACCGGACACTAAACCCAAAATTAAGGATAAT
GGAGATCTGGTTTTGTCAAGCCCCAGTAATGTAACACTGCCCCAAGTGAAAACAGAAAAA
GAAGATTTCATCGAACTCTGCACCCCTGGGGTAATTAAGCAAGAGAAACTGGGCACAGTT
TACTGTCAGGCAAGCTTTCCTGGAGCAAATATAATTGGTAATAAAATGTCTGCCATTTCT
GTTCATGGTGTGAGTACCTCTGGAGGACAGATGTACCACTATGACATGAATACAGCATCC
CTTTCTCAACAGCAGGATCAGAAGCCTATTTTTAATGTCATTCCACCAATTCCCGTTGGT
TCCGAAAATTGGAATAGGTGCCAAGGATCTGGAGATGACAACTTGACTTCTCTGGGGACT
CTGAACTTCCCTGGTCGAACAGTTTTTTCTAATGGCTATTCAAGCCCCAGCATGAGACCA
GATGTAAGCTCTCCTCCATCCAGCTCCTCAACAGCAACAACAGGACCACCTCCCAAACTC
TGCCTGGTGTGCTCTGATGAAGCTTCAGGATGTCATTATGGAGTCTTAACTTGTGGAAGC
TGTAAAGTTTTCTTCAAAAGAGCAGTGGAAGGACAGCACAATTACCTATGTGCTGGAAGG
AATGATTGCATCATCGATAAAATTCGAAGAAAAAACTGCCCAGCATGCCGCTATCGAAAA
TGTCTTCAGGCTGGAATGAACCTGGAAGCTCGAAAAACAAAGAAAAAAATAAAAGGAATT
CAGCAGGCCACTACAGGAGTCTCACAAGAAACCTCTGAAAATCCTGGTAACAAAACAATA
GTTCCTGCAACGTTACCACAACTCACCCCTACCCTGGTGTCACTGTTGGAGGTTATTGAA
CCTGAAGTGTTATATGCAGGATATGATAGCTCTGTTCCAGACTCAACTTGGAGGATCATG
ACTACGCTCAACATGTTAGGAGGGCGGCAAGTGATTGCAGCAGTGAAATGGGCAAAGGCA
ATACCAGGTTTCAGGAACTTACACCTGGATGACCAAATGACCCTACTGCAGTACTCCTGG
ATGTTTCTTATGGCATTTGCTCTGGGGTGGAGATCATATAGACAATCAAGTGCAAACCTG
CTGTGTTTTGCTCCTGATCTGATTATTAATGAGCAGAGAATGACTCTACCCTGCATGTAC
GACCAATGTAAACACATGCTGTATGTTTCCTCTGAGTTACACAGGCTTCAGGTATCTTAT
GAAGAGTATCTCTGTATGAAAACCTTACTGCTTCTCTCTTCAGTTCCTAAGGACGGTCTG
AAGAGCCAAGAGCTATTTGATGAAATTAGAATGACCTACATCAAAGAGCTAGGAAAAGCC
ATTGTCAAGAGGGAAGGAAACTCCAGCCAGAACTGGCAGCGGTTTTATCAACTGACAAAA
CTCTTGGATTCTATGCATGAAGTGGTTGAAAATCTCCTTAACTATTGCTTCCAAACATTT
TTGGATAAGACCATGAGTATTGAATTCCCCGAGATGTTAGCTGAAATCATCACCAATCAG
ATACCAAAATATTCAAATGGAAATATCAAAAAACTTCTGTTTCATCAAAAGTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
X03225

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_3_Locus:
5q31.3

# Macromolecular_Interacting_Partner_3_SNPs:
rs6192; rs6190; rs6195; rs6196; rs6189; rs6194; rs258751; rs6199; rs6193; rs4912910; rs6191; rs10052957; rs7701443; rs4912909; rs12656106; rs4607376; rs4244032; rs4403203; rs9324924; rs5871845; rs4912911; rs9324922; rs6198; rs10482605; rs10477211; rs13185164; rs13162395; rs4529231; rs4582314; rs4244031; rs10482611; rs10482620; rs12513857; rs6865292; rs4457111; rs9324923; rs4634384; rs11167811; rs6896209; rs4518434; rs12655166; rs10482609; rs4912912; rs10482616; rs11749561; rs13182800; rs10482603; rs10482617; rs10482707; rs17302697; rs10482610; rs10482714; rs4406157; rs7719514; rs17100289; rs6197; rs3806854; rs13186836; rs4518436; rs7723528; rs10482614; rs13170129; rs6882102; rs28364694; rs13153270; rs10482712; rs13155635; rs11747997; rs12653301; rs10043090; rs13184611; rs11167810; rs10482716; rs2301177; rs3806855; rs12054797; rs12515985; rs2918417; rs2918416; rs1866388; rs852980; rs33388; rs258813; rs6188; rs2963156; rs258750; rs852977; rs2918418; rs6877893; rs4986593; rs9324915; rs6866890; rs852982; rs1438732; rs2918419; rs9324914; rs10041520; rs12652915; rs10078410; rs4912905; rs10054283; rs852978; rs864082; rs33389; rs17209251; rs10482625; rs9324916; rs852976; rs10515522; rs2043840; rs10482655; rs2963145; rs9324918; rs12386466; rs11740792; rs11955803; rs9324917; rs2963152; rs9324921; rs4128428; rs10042644; rs258814; rs2118727; rs2398631; rs9324913; rs10482640; rs13355103; rs4912650; rs10482641; rs10482665; rs9324920; rs10482634; rs10482636; rs6871322; rs7716360; rs17100234; rs11745958; rs9324912; rs17339831; rs10482650; rs13358709; rs10482682; rs1438731; rs2963146; rs10515521; rs9324911; rs10482633; rs190488; rs852981; rs10482672; rs10482642; rs10482637; rs13306587; rs852979; rs10482630; rs13176292; rs2918415; rs10066267; rs10482646; rs10482668; rs17100236; rs10482669; rs10482654; rs10482679; rs10482704; rs10076665; rs2963155; rs11740747; rs10482631; rs17209258; rs4912907; rs10482676; rs10482681; rs2918421; rs10482701; rs10482688; rs10482638; rs10482689; rs13360865; rs1837262; rs17339455; rs10482686; rs13360160; rs10482667; rs13353867; rs10072193; rs10071869; rs10038016; rs852975; rs13171962; rs10482700; rs10482643; rs12109552; rs11750172; rs10045381; rs10482658; rs10055443; rs10041957; rs10042903; rs17399352; rs10482626; rs10482653; rs7730946; rs10076037; rs10482675; rs13178847; rs6861962; rs2963151; rs10040972; rs10042897; rs10042042; rs10053679; rs33380; rs10482659; rs2307674; rs3776216; rs10482690; rs13186482; rs10482628; rs10041040; rs13180461; rs2963154; rs12655424; rs9324919; rs10060545; rs10482645; rs1305061; rs11742942; rs3822376; rs34562334; rs10043707; rs10482698; rs10055444; rs10051482; rs10482693; rs10482623; rs10482683; rs17100237; rs13353891; rs13361140; rs10482639; rs2963149; rs10038464; rs860457; rs258747; rs6868190; rs17287758; rs258748; rs17209237; rs33391; rs1800445; rs10482622; rs13306589; rs13306588; rs13160969; rs11292842; rs10482621; rs10482618; rs35515833; rs13166252; rs10482608; rs13173940; rs10482606; rs35257270; rs10477210; rs5871844; rs5871846; rs34113205; rs13306586; rs4585488; rs34519266; rs6187; rs35726834; rs28546630; rs10482619; rs10482612; rs13306585; rs33978809; rs34580792; rs13166717; rs33968115; rs35132206; rs4244033; rs34123577; rs10482711; rs10482706; rs35956102; rs4441905; rs4075426; rs35159833; rs28392717; rs35174661; rs4912908; rs10577951; rs36208514; rs34471178; rs10482708; rs35314635; rs36028129; rs28635164; rs4367320; rs35715139; rs34248080; rs10482613; rs34027900; rs10482709; rs10482713; rs35555700; rs35500391; rs34449288; rs6894830; rs35728985; rs10482710; rs10482604; rs13178409; rs34207899; rs12652149; rs10482607; rs34226461; rs13176328; rs1803634; rs34861052; rs10440742; rs35224915; rs35722527; rs4434414; rs5871847; rs13169606; rs36029993; rs35296125; rs12189168; rs34569272; rs10482615; rs35612073; rs34961947; rs35290813; rs28609103; rs10043662; rs4388235; rs34396341; rs10482715; rs36208517; rs11552272; rs5871843; rs35572256; rs10482657; rs10482691; rs13158118; rs10038827; rs34523349; rs35918104; rs35271349; rs10043423; rs4912906; rs10477206; rs10482661; rs2398628; rs10482678; rs35786621; rs10482677; rs33963148; rs35947578; rs13358784; rs10482680; rs35598337; rs35023410; rs35592572; rs9654496; rs13169116; rs13359753; rs13356889; rs10053963; rs10477207; rs35020221; rs34756958; rs36027185; rs35396295; rs34641849; rs10037525; rs34808627; rs174050; rs2079687; rs34530390; rs10482644; rs3836768; rs28865014; rs4608948; rs34209560; rs10039663; rs10482647; rs10482670; rs10477208; rs860458; rs34841797; rs13169117; rs2963147; rs36008199; rs10042038; rs34427874; rs10482697; rs2963150; rs3861852; rs35245606; rs35176817; rs10062225; rs10477209; rs34535209; rs10482629; rs10073248; rs34319493; rs2022117; rs34780316; rs10482660; rs35624123; rs35302985; rs35299297; rs10482635; rs1140000; rs13306584; rs34194480; rs7715728; rs34260076; rs7734158; rs10482649; rs28822503; rs34638922; rs36090270; rs28453280; rs10045200; rs34152766; rs10482696; rs34346366; rs34743734; rs10055574; rs35527602; rs10035222; rs36010586; rs10037693; rs10482664; rs10482684; rs10482652; rs10482627; rs28821527; rs10482673; rs10482674; rs10482703; rs2963148; rs10060741; rs10482695; rs10053200; rs41423247; rs35655055; rs852974; rs10054713; rs10482624; rs34827388; rs34686112; rs10482692; rs35667604; rs10482694; rs35039262; rs2398629; rs34992369; rs10482687; rs35713866; rs10482685; rs2918420; rs10482666; rs35502804; rs10482648; rs10477204; rs33952897; rs36027730; rs34778988; rs10036278; rs2282800; rs11395012; rs33382; rs10042945; rs13361442; rs10036628; rs35923465; rs35999293; rs35241746; rs10214015; rs4912904; rs10041074; rs6882247; rs28791803; rs10482662; rs10482699; rs34186246; rs34494535; rs35434651; rs10482671; rs10482632; rs10482705; rs13355270; rs33944801; rs34632939; rs2963153; rs33381; rs35507823; rs34176759; rs34763421; rs10482656; rs34340042; rs10482702; rs10065326; rs6873841; rs36105398; rs10482651; rs35696265; rs185434; rs10079976; rs10036734; rs35335992; rs11378193; rs34911720; rs10482663; rs4437403; rs34019216; rs35067504; rs10482717; rs34876003; rs10041406; rs12519083; rs12521436; rs13190019; rs17287745; rs174048; rs258763; rs33383; rs4912913; rs7448383; rs7701582; rs7709864; rs7728835

# Macromolecular_Interacting_Partner_3_General_References:
2867473; 1707881; 2026589; 1958537; 11435610; 3841189; 9154805; 9590696; 10477749; 10566686; 8358712; 10902803; 10866662; 10639135; 11555652; 11238589; 12144530; 12000743; 12415108; 12151000; 12686538; 1704018; 8358735; 8445027; 7683692; 8316249; 9150737; 10391209; 10898924; 11589680; 11344238; 11701741; 11932321; 12050230

# Macromolecular_Interacting_Partner_3_References:
1971967; 3491118; 3741883; 6188228

End of HMDB00015

Beginning of HMDB00016
# Accession_No:
HMDB00016

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-15 10:45:19

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Deoxycorticosterone

# Description:
A steroid or mineralocorticoid secreted by the adrenal cortex. Deoxycorticsterone acts as a precursor to aldosterone.  It can be used to treat adrenal insufficiency.  In particular, desoxycorticosterone acetate (DOCA) is used as replacement therapy in Addison's disease.

# Synonyms:
11-Dehydroxycorticosterone; 11-Deoxycorticosterone; 11-Desoxycorticosterone; 11-deoxy-Corticosterone; 21-Hydroxy-3,20-dioxopregn-4-ene; 21-Hydroxy-D4-pregnane-3,20-dione; 21-Hydroxy-D4-pregnene-3,20-dione; 21-Hydroxypregn-4-ene-3,20-dione; 21-Hydroxyprogesterone; 21-hydroxy-Pregn-4-ene-3,20-dione; 21-hydroxy-Progesterone; 4-Pregnen-21-ol-3,20-dione; Cortexone; D4-Pregnene-21-ol-3,20-dione; DOC; Deoxycortone; Desoxycorticosterone; Desoxycortone; Doca; Kendall's desoxy compound B; Reichstein's substance Q

# Chemical_IUPAC_Name:
17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

# Chemical_Formula:
C21H30O3

# Chemical_Structure:
tbl_chemical:::HMDB00016_ZOOM.png:::11928313002392616

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00016_THUMB.png:::119283129809184044

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Steroids; Sterols

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
ketone; primary alcohol; alkene

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
330.21948

# Molecular_Weight_Avg:
330.46109

# Smiles_String_isomeric:
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO

# Smiles_String_canonical:
CC12CCC3C(CCC4=CC(=O)CCC34C)C1CCC2C(=O)CO

# KEGG_Compound_ID:
C03205

# BioCyc_ID:
11-DEOXYCORTICOSTERONE

# PubChem_CID:
6166

# PubChem_SID:
11466985; 149067; 8153870; 3136426; 6081; 11486839; 11468105; 855538; 8144739; 841768; 7885076

# OMIM_ID:
138040; 201910; 202010; 203400

# Metagene_ID:
11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1): 458; 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17): 321

# BiGG_ID:
41397

# Wikipedia_ID:
Deoxycorticosterone

# METLIN_ID:
5089

# Ref_ID:
11423756; 2164659; 15181062; 7462398; 1751389; 1423019; 12119960; 15483094; 16112410; 15947887; 15134803; 8081391; 15117882; 15816373; 1555868; 15780662; 2808702; 871129; 15167270; 9746224

# ChEBI_ID:
16973

# CAS_Registry_Number:
64-85-7

# InChI:
InChI=1/C21H30O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h11,15-18,22H,3-10,12H2,1-2H3/t15-,16-,17-,18+,20-,21-/m0/s1

# Synthesis_Reference:
Schindler, W. etal., Helv. Chim. Acta, 1941, 24, 371; Zaffaroni, A. etal., Experientia, 1955, 11, 219; U.S. Pat., 1966, 3 254 098 CA, 65, 8999; van der Sijde, D. etal., Rec. Trav. Chim. (J. R. Neth. Chem. Soc.), 1969, 88, 1437; Numazawa, M. etal., J.O.C.,

# Melting_Point:
141-142 oC

# Melting_Point_predicted:
129.3 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.0595 mg/mL at 37 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
0.0167 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
2.88 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
3.10 [Predicted by ALOGPS]; 2.5 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C03205.mol:::1132723801328422785

# SDF_File_[Text]:
tbl_chemical:::HMDB00016.sdf:::119283128975077223

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00016.pdb:::11928312964036270

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::050118_P00_07_IS_1DP.zip:::117104462555686060

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050118_P00_07_IS_assigned.png:::119205470912749991

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050118_P00_07_IS_207.png:::11924667192104559

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050118_P00_07_IS_207.zip:::119246671927742914

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050118_P00_07_IS_207_Assigned.png:::119246671953182530

# Predicted_H_NMR_Spectrum:
tbl_chemical:::11-Deoxycorticosterone.gif:::1132732098921318004

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00016_peaks.txt:::1156309486195670785

# Predicted_C_NMR_Spectrum:
tbl_chemical:::11-Deoxycorticosterone_C.gif:::1132737657447977146

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00016_peaks.txt:::1156310678215166512

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00016L.png:::117555263001070051; Medium Energy:tbl_ms:::HMDB00016M.png:::117555268387782026; High Energy:tbl_ms:::HMDB00016H.png:::117555271680463630

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane; Cytoplasm; endoplasmic reticulum; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Amniotic Fluid; Blood

# Concentration_[Normal]:
Blood	0.073 (0.034-0.11)	uM	Adult:>18_yrs_old	Female	Normal	12119960


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
11-Hydroxylase Deficiency; 17-Hydroxylase Deficiency; Adrenal Adenoma; Congenital Adrenal Hyperplasia; Malignant Hypertension

# Pathway_Names:
C21-Steroid hormone metabolism;Androgen and estrogen metabolism

# Pathway_Images:
;

# KEGG_Images:
map00140;map00150

# Pathway_Graphs:
;

# Pathway_SBMLs:
;

# Metabolic_Enzyme_1_ID:
5737

# Metabolic_Enzyme_1_Name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II

# Metabolic_Enzyme_1_Synonyms:
3- beta-HSD II[Includes: 3-beta-hydroxy-Delta(5-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta-isomerase; Delta- 5-3-ketosteroid isomerase]

# Metabolic_Enzyme_1_Gene_Name:
HSD3B2

# Metabolic_Enzyme_1_Protein_Sequence:
>3 betahydroxysteroid dehydrogenase/Delta 5>4isomerase type II
MGWSCLVTGAGGLLGQRIVRLLVEEKELKEIRALDKAFRPELREEFSKLQNRTKLTVLEG
DILDEPFLKR
ACQDVSVVIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVF
IYTSSIEVAGPNSYKEIIQNG
HEEEPLENTWPTPYPYSKKLAEKAVLAANGWNLKNGDT
LYTCALRPTYIYGEGGPFLSASINEALNNNGI
LSSVGKFSTVNPVYVGNVAWAHILALR
ALRDPKKAPSVRGQFYYISDDTPHQSYDNLNYILSKEFGLRLD
SRWSLPLTLMYWIGFL
LEVVSFLLSPIYSYQPPFNRHTVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQ
KTVEW
VGSLVDRHKETLKSKTQ

# Metabolic_Enzyme_1_Number_of_Residues:
372

# Metabolic_Enzyme_1_Molecular_Weight:
42053

# Metabolic_Enzyme_1_Theoretical_pI:
8.17

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, transposing C=C bonds
Function:  steroid delta-isomerase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  3-beta-hydroxy-delta5-steroid dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_1_Specific_Function:
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids

# Metabolic_Enzyme_1_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_1_Reaction:
A 3-oxo-delta5-steroid = a 3-oxo-delta4-steroid

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01073:3Beta_HSD

# Metabolic_Enzyme_1_Signals:
1-15

# Metabolic_Enzyme_1_Transmembrane_Regions:
287-307

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.1.1.145;EC 5.3.3.1

# Metabolic_Enzyme_1_GenBank_ID_Protein:
184401

# Metabolic_Enzyme_1_SwissProt_ID:
3BHS2_HUMAN (P26439)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
HSD3B2

# Metabolic_Enzyme_1_Geneatlas_id:
HSD3B2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:5218

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein. Mitochondrion; mitochondrial membrane; single-pass membrane protein

# Metabolic_Enzyme_1_Gene_Sequence:
>1119 bp

ATGGGCTGGAGCTGCCTTGTGACAGGAGCAGGAGGGCTTCTGGGTCAGAGGATCGTCCG
CCTGTTGGTGG
AAGAGAAGGAACTGAAGGAGATCAGGGCCTTGGACAAGGCCTTCAGAC
CAGAATTGAGAGAGGAATTTTC
TAAGCTCCAGAACAGGACCAAGCTGACTGTACTTGAA
GGAGACATTCTGGATGAGCCATTCCTGAAAAGA
GCCTGCCAGGACGTCTCGGTCGTCAT
CCACACCGCCTGTATCATTGATGTCTTTGGTGTCACTCACAGAG
AGTCCATCATGAATG
TCAATGTGAAAGGTACCCAGCTACTGTTGGAGGCCTGTGTCCAAGCCAGTGTGCC
AGTC
TTCATCTACACCAGTAGCATAGAGGTAGCCGGGCCCAACTCCTACAAGGAAATCATCCAG
AACGGC
CACGAAGAAGAGCCTCTGGAAAACACATGGCCCACTCCATACCCGTACAGCAA
AAAGCTTGCTGAGAAGG
CTGTGCTGGCGGCTAATGGGTGGAATCTAAAAAATGGTGATA
CCTTGTACACTTGTGCGTTAAGACCCAC
ATATATCTATGGGGAAGGAGGCCCATTCCTT
TCTGCCAGTATAAATGAGGCCCTGAACAACAATGGGATC
CTGTCAAGTGTTGGAAAGTT
CTCTACAGTCAACCCAGTCTATGTTGGCAACGTGGCCTGGGCCCACATTC
TGGCCTTGA
GGGCTCTGCGGGACCCCAAGAAGGCCCCAAGTGTCCGAGGTCAATTCTATTACATCTCAG
A
TGACACGCCTCACCAAAGCTATGATAACCTTAATTACATCCTGAGCAAAGAGTTTGGC
CTCCGCCTTGAT
TCCAGATGGAGCCTTCCTTTAACCCTGATGTACTGGATTGGCTTCCT
GCTGGAAGTAGTGAGCTTCCTAC
TCAGCCCAATTTACTCCTATCAACCCCCCTTCAACC
GCCACACAGTCACATTATCAAATAGTGTGTTCAC
CTTCTCTTACAAGAAGGCTCAGCGA
GATCTGGCGTATAAGCCACTCTACAGCTGGGAGGAAGCCAAGCAG
AAAACCGTGGAGTG
GGTTGGTTCCCTTGTGGACCGGCACAAGGAGACCCTGAAGTCCAAGACTCAGTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M67466

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_1_Locus:
1p13.1

# Metabolic_Enzyme_1_SNPs:
rs4986954; rs6211; rs35887327; rs6207; rs33926546; rs34412477; rs33932258; rs1819698; rs1361530; rs9282704; rs6208; rs6210; rs9282703; rs3753258; rs12411115; rs2854961; rs33920337; rs17023577; rs12044792; rs2854964; rs10923817; rs3765948; rs12411080; rs2854963; rs2793133; rs7411891; rs2854962; rs2793132; rs6676988; rs4659174; rs12062744; rs33952871; rs33963971; rs4659175; rs35983269; rs34492690; rs34177617; rs35954381; rs35344469; rs35569514; rs9282705; rs28943871; rs35613222; rs28934880; rs35486059; rs34562248; rs714748; rs10591825; rs10616581; rs34234813; rs12741109; rs3057393; rs35081017; rs3820030; rs6692175; rs10616582; rs12742063; rs12404035; rs12741125; rs36021225; rs36022499; rs5777392; rs12723698; rs35507723; rs35448442; rs35847875; rs34282330; rs10754396; rs10923815; rs10923819; rs10923820; rs11579951; rs12022215; rs12403392; rs12404131; rs12405488; rs1341018; rs17023564; rs2185556; rs2185557; rs6661603; rs947129

# Metabolic_Enzyme_1_General_References:
1944309; 1741954; 8316254; 7833923; 8126127; 7962268; 8185809; 8060486; 7893703; 7633426; 7633460; 7608265; 9719627; 10599696; 10651755; 10843183; 12050213

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5738

# Metabolic_Enzyme_2_Name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I

# Metabolic_Enzyme_2_Synonyms:
3- beta-HSD I; Trophoblast antigen FDO161G[Includes: 3-beta-hydroxy- Delta(5-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta- isomerase; Delta-5-3-ketosteroid isomerase]

# Metabolic_Enzyme_2_Gene_Name:
HSD3B1

# Metabolic_Enzyme_2_Protein_Sequence:
>3 betahydroxysteroid dehydrogenase/Delta 5>4isomerase type I
MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELREEFSKLQNKTKLTVLE
GDILDEPFLK
RACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPV
FIYTSSIEVAGPNSYKEIIQN
GHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGG
TLYTCALRPMYIYGEGSRFLSASINEALNNNG
ILSSVGKFSTVNPVYVGNVAWAHILAL
RALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRL
DSRWSFPLSLMYWIGF
LLEIVSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAK
QKTVE
WVGSLVDRHKETLKSKTQ

# Metabolic_Enzyme_2_Number_of_Residues:
373

# Metabolic_Enzyme_2_Molecular_Weight:
42252

# Metabolic_Enzyme_2_Theoretical_pI:
8.98

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, transposing C=C bonds
Function:  steroid delta-isomerase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  3-beta-hydroxy-delta5-steroid dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_2_Specific_Function:
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids

# Metabolic_Enzyme_2_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_2_Reaction:
A 3-oxo-delta5-steroid = a 3-oxo-delta4-steroid

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01073:3Beta_HSD

# Metabolic_Enzyme_2_Signals:
1-13

# Metabolic_Enzyme_2_Transmembrane_Regions:
288-308

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.1.145;EC 5.3.3.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
306889

# Metabolic_Enzyme_2_SwissProt_ID:
3BHS1_HUMAN (P14060)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
HSD3B1

# Metabolic_Enzyme_2_Geneatlas_id:
HSD3B1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:5217

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein. Mitochondrion; mitochondrial membrane; single-pass membrane protein

# Metabolic_Enzyme_2_Gene_Sequence:
>1122 bp

ATGACGGGCTGGAGCTGCCTTGTGACAGGAGCAGGAGGGTTTCTGGGACAGAGGATCAT
CCGCCTCTTGG
TGAAGGAGAAGGAGCTGAAGGAGATCAGGGTCTTGGACAAGGCCTTCG
GACCAGAATTGAGAGAGGAATT
TTCTAAACTCCAGAACAAGACCAAGCTGACAGTGCTG
GAAGGAGACATTCTGGATGAGCCATTCCTGAAG
AGAGCCTGCCAGGACGTCTCGGTCAT
CATCCACACCGCCTGTATCATTGATGTCTTCGGTGTCACTCACA
GAGAGTCTATCATGA
ATGTCAATGTGAAAGGTACCCAGCTCCTGTTAGAGGCCTGTGTCCAAGCTAGTGT
GCCA
GTCTTCATCTACACCAGTAGCATAGAGGTAGCCGGGCCCAACTCCTACAAGGAAATCATC
CAGAAT
GGCCATGAAGAAGAGCCTCTGGAAAACACATGGCCCGCTCCATACCCACACAG
CAAAAAGCTTGCTGAGA
AGGCTGTACTGGCGGCTAACGGGTGGAATCTGAAAAACGGCG
GCACCCTGTACACTTGTGCCTTACGACC
CATGTATATCTATGGGGAAGGAAGCCGATTC
CTTTCTGCTAGTATAAACGAGGCCCTGAACAACAATGGG
ATCCTGTCAAGTGTTGGAAA
GTTCTCCACTGTTAACCCAGTCTATGTTGGCAATGTGGCCTGGGCCCACA
TTCTGGCCT
TGAGGGCCCTGCAGGACCCCAAGAAGGCCCCAAGCATCCGAGGACAGTTCTACTATATCT
C
AGATGACACGCCTCACCAAAGCTATGATAACCTTAATTACACCCTGAGCAAAGAGTTC
GGCCTCCGCCTT
GATTCCAGATGGAGCTTTCCTTTATCCCTGATGTATTGGATTGGCTT
CCTGCTGGAAATAGTGAGCTTCC
TACTCAGGCCAATTTACACCTATCGACCGCCCTTCA
ACCGCCACATAGTCACATTGTCAAATAGCGTATT
CACCTTCTCTTATAAGAAGGCTCAG
CGAGATCTGGCGTATAAGCCACTCTACAGCTGGGAGGAAGCCAAG
CAGAAAACGGTGGA
GTGGGTTGGTTCCCTTGTGGACCGGCACAAGGAGACCCTGAAGTCCAAGACTCAGT
GA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M27137

# Metabolic_Enzyme_2_Chromosome_Location:
Not Available

# Metabolic_Enzyme_2_Locus:
Not Available

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
2779585; 2139411; 2082186; 2243100; 1920284; 1401999; 10391209

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5683

# Metabolic_Enzyme_3_Name:
Cytochrome P450 11B1, mitochondrial precursor

# Metabolic_Enzyme_3_Synonyms:
CYPXIB1; P450C11; P-450c11; Steroid 11-beta-hydroxylase

# Metabolic_Enzyme_3_Gene_Name:
CYP11B1

# Metabolic_Enzyme_3_Protein_Sequence:
>Cytochrome P450 11B1, mitochondrial precursor
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPQRPGNRWLRLLQIWREQG
YEDLHLEVHQ
TFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAY
RQHRGHKCGVFLLNGPEWRFN
RLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQ
NARGSLTLDVQPSIFHYTIEASNLALFGERLG
LVGHSPSSASLNFLHALEVMFKSTVQL
MFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF
SRPQQYTSIVAELLLN
AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAAS
ISEHP
QKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVRVFLYSLGRNPA
LFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE
TLTQEDIKMVYSFILR
PSMCPLLTFRAIN

# Metabolic_Enzyme_3_Number_of_Residues:
503

# Metabolic_Enzyme_3_Molecular_Weight:
57530

# Metabolic_Enzyme_3_Theoretical_pI:
9.42

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_3_Specific_Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB

# Metabolic_Enzyme_3_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_3_Reaction:
a steroid + reduced adrenal ferredoxin + O2 = an 11beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_3_Signals:
1-23

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.14.15.4

# Metabolic_Enzyme_3_GenBank_ID_Protein:
181333

# Metabolic_Enzyme_3_SwissProt_ID:
C11B1_HUMAN (P15538)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
CYP11B1

# Metabolic_Enzyme_3_Geneatlas_id:
CYP11B1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:2591

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_3_Gene_Sequence:
>1512 bp

ATGGCACTCAGGGCAAAGGCAGAGGTGTGCATGGCAGTGCCCTGGCTGTCCCTGCAAAG
GGCACAGGCAC
TGGGCACGAGAGCCGCCCGGGTCCCCAGGACAGTGCTGCCCTTTGAAG
CCATGCCCCGGCGTCCAGGCAA
CAGGTGGCTGAGGCTGCTGCAGATCTGGAGGGAGCAG
GGTTATGAGGACCTGCACCTGGAAGTACACCAG
ACCTTCCAGGAACTGGGGCCCATTTT
CAGGTACGATTTGGGAGGAGCAGGCATGGTGTGTGTGATGCTGC
CGGAGGACGTGGAGA
AGCTGCAACAGGTGGACAGCCTGCATCCCCACAGGATGAGCCTGGAGCCCTGGGT
GGCC
TACAGACAACATCGTGGGCACAAATGTGGCGTGTTCTTGCTGAATGGGCCTGAATGGCGC
TTCAAC
CGATTGCGGCTGAATCCAGAAGTGCTGTCGCCCAACGCTGTGCAGAGGTTCCT
CCCGATGGTGGATGCAG
TGGCCAGGGACTTCTCCCAGGCCCTGAAGAAGAAGGTGCTGC
AGAACGCCCGGGGGAGCCTGACCCTGGA
CGTCCAGCCCAGCATCTTCCACTACACCATA
GAAGCCAGCAACTTGGCTCTTTTTGGAGAGCGGCTGGGC
CTGGTTGGCCACAGCCCCAG
TTCTGCCAGCCTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCA
CCGTCCAGC
TCATGTTCATGCCCAGGAGCCTGTCTCGCTGGACCAGCCCCAAGGTGTGGAAGGAGCACT
T
TGAGGCCTGGGACTGCATCTTCCAGTACGGCGACAACTGTATCCAGAAAATCTATCAG
GAACTGGCCTTC
AGCCGCCCTCAACAGTACACCAGCATCGTGGCGGAGCTCCTGTTGAA
TGCGGAACTGTCGCCAGATGCCA
TCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCG
TGGACACGACGGTGTTTCCCTTGCTGATGACGCT
CTTTGAGCTGGCTCGGAACCCCAAC
GTGCAGCAGGCCCTGCGCCAGGAGAGCCTGGCCGCCGCAGCCAGC
ATCAGTGAACATCC
CCAGAAGGCAACCACCGAGCTGCCCTTGCTGCGTGCGGCCCTCAAGGAGACCTTGC
GGC
TCTACCCTGTGGGTCTGTTTCTGGAGCGAGTGGCGAGCTCAGACTTGGTGCTTCAGAACT
ACCACAT
CCCAGCTGGGACATTGGTGCGCGTGTTCCTCTACTCTCTGGGTCGCAACCCC
GCCTTGTTCCCGAGGCCT
GAGCGCTATAACCCCCAGCGCTGGCTAGACATCAGGGGCTC
CGGCAGGAACTTCTACCACGTGCCCTTTG
GCTTTGGCATGCGCCAGTGCCTTGGGCGGC
GCCTGGCAGAGGCAGAGATGCTGCTGCTGCTGCACCATGT
GCTGAAACACCTCCAGGTG
GAGACACTAACCCAAGAGGACATAAAGATGGTCTACAGCTTCATATTGAGG
CCCAGCAT
GTGCCCCCTCCTCACCTTCAGAGCCATCAACTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M32879

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_3_Locus:
8q21

# Metabolic_Enzyme_3_SNPs:
rs4541; rs4534; rs5288; rs5294; rs6405; rs34620645; rs6410; rs5283; rs5290; rs6403; rs6419; rs34570566; rs5316; rs5284; rs5299; rs5301; rs7003319; rs5304; rs1134096; rs5303; rs1134095; rs5017238; rs5297; rs4736312; rs5300; rs3802229; rs6389; rs9657021; rs4310186; rs6388; rs7822986; rs6471570; rs6387; rs4535; rs4736315; rs10956991; rs5295; rs6393; rs7814006; rs7814020; rs7818826; rs4609179; rs7818953; rs11775687; rs6390; rs6398; rs10105643; rs6400; rs6392; rs12674916; rs7833415; rs6411; rs6391; rs12542799; rs6402; rs6395; rs6422; rs6409; rs5280; rs4736346; rs10093618; rs4736311; rs4471016; rs4313136; rs5292; rs28934586; rs5287; rs5282; rs4998901; rs5291; rs4998896; rs6407; rs4998898; rs4998902; rs4998900; rs4998899; rs4998903; rs4998897; rs9657022; rs5296; rs4998895; rs1137481; rs1137484; rs5302; rs35673190; rs5017237; rs1137480; rs1137485; rs12543598; rs5298; rs34274727; rs1137488; rs5017240; rs5027479; rs1137486; rs1137483; rs5027480; rs5017239; rs1137487; rs5027478; rs4998894; rs9657020; rs4999335; rs4236887; rs5286; rs13250178; rs4999334; rs35378570; rs28551743; rs36004897; rs5895733; rs34698173; rs12114482; rs28418310; rs10098023; rs4464947; rs4548164; rs4581033; rs4736308; rs4736309; rs4736310; rs4736349; rs4736350; rs6995180; rs7005638; rs7016088; rs7016594

# Metabolic_Enzyme_3_General_References:
2592361; 2401360; 7903314; 3499608; 1741400; 2022736; 9302260; 10599751; 10391209; 10391210

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5808

# Metabolic_Enzyme_4_Name:
Cytochrome P450 11B2, mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
CYPXIB2; P-450Aldo; Aldosterone synthase; ALDOS; Aldosterone-synthesizing enzyme; Steroid 18-hydroxylase; P-450C18

# Metabolic_Enzyme_4_Gene_Name:
CYP11B2

# Metabolic_Enzyme_4_Protein_Sequence:
>Cytochrome P450 11B2, mitochondrial precursor
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN

# Metabolic_Enzyme_4_Number_of_Residues:
503

# Metabolic_Enzyme_4_Molecular_Weight:
57561

# Metabolic_Enzyme_4_Theoretical_pI:
9.78

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_4_Specific_Function:
Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone

# Metabolic_Enzyme_4_Pathway:
map00140  C21-Steroid hormone metabolism;
GENES       HSA: 1584(CYP11B1) 1585(CYP11B2);
            MMU: 13072(Cyp11b2) 223628(LOC223628);
            RNO: 24293(Cyp11b1) 24294(Cyp11b2) 353498(Cyp11b3)

# Metabolic_Enzyme_4_Reaction:
corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.14.15.4;EC 1.14.15.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
181340

# Metabolic_Enzyme_4_SwissProt_ID:
C11B2_HUMAN (P19099)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CYP11B2

# Metabolic_Enzyme_4_Geneatlas_id:
CYP11B2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:2592

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_4_Gene_Sequence:
>1512 bp
ATGGCACTCAGGGCAAAGGCAGAGGTGTGCGTGGCAGCGCCCTGGCTGTGCCTGCAAAGG
GCACGGGCACTGGGCACTAGAGCCGCTCGGGCCCCTAGGACGGTGCTGCCGTTTGAAGCC
ATGCCCCAGCATCCAGGCAACAGGTGGCTGAGGCTGCTGCAGATGTGGAGGGAGCAGGGT
TATGAGCACCTGCACCTGGAGATGCACCAGACCTTCCAGGAGCTGGGGCCCATTTTCAGG
TACAACTTGGGAGGACCACGCATGGTGTGTGTGATGCTGCCGGAGGATGTGGAGAAGCTG
CAACAGGTGGACAGCCTGCATCCCTGCAGGATGATCCTGGAGCCCTGGGTGGCCATCAGA
CAACATCGTGGGCACAAATGTGGCGTGTTCTTGTTGAATGGGCCTGAATGGCGCTTCAAC
CGATTGCGGCTGAACCCAGATGTGCTGTCGCCCAAGGCCGTGCAGAGGTTCCTCCCGATG
GTGGATGCAGTGGCCAGGGACTTTTCCCAGGCCCTGAGGAAGAAGGTGCTGCAGAACGCC
CGGGGGAGCCTGACCCTGGACGTCCAGCCCAGCATCTTCCACTACACCATAGAAGCCAGC
AACTTAGCTCTTTTTGGAGAGCGGCTGGGCCTGGTTGGCCACAGCCCCAGTTCTGCCAGC
CTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCACCGTCCAGCTCATGTTCATG
CCCAGGAGCCTGTCTCGCTGGATCAGCCCCAAGGTGTGGAAGGAGCACTTTGAGGCCTGG
GACTGCATCTTCCAGTACGGTGACAACTGTATCCAGAAAATCTACCAGGAACTGGCCTTC
AACCGCCCTCAACACTACACAGGCATCGTGGCAGAGCTCCTGTTGAAGGCGGAACTGTCA
CTAGAAGCCATCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCGTGGACACGACAGCG
TTTCCGTTGCTGATGACGCTCTTTGAGCTGGCTCGGAACCCCGACGTGCAGCAGATCCTG
CGCAAGGAGAGCCTGGCCGCCGCAGCCAGCATCAGTGAACATCCCCAGAAGGCAACCACC
GAGCTGCCCTTGCTGCGGGCGGCCCTCAAGGAGACCTTGAGGCTCTACCCTGTGGGTCTG
TTTTTGGAGCGAGTGGTGAGCTCAGACTTGGTGCTTCAGAACTACCACATCCCAGCTGGG
ACATTGGTACAGGTTTTCCTCTACTCGCTGGGTCGCAATGCCGCCTTGTTCCCGAGGCCT
GAGCGGTATAATCCCCAGCGCTGGCTAGACATCAGGGGCTCCGGCAGGAACTTGCACCAC
GTGCCCTTTGGCTTTGGCATGCGCCAGTGCCTCGGGCGGCGCCTGGCAGAGGCAGAGATG
CTGCTGCTGCTGCACCACGTGCTGAAGCGCTTCCTGGTGGAGACACTAACTCAAGAGGAC
ATAAAGATGGTCTACAGCTTCATATTGAGGCCTGGCACGTCCCCCCTCCTCACTTTCAGA
GCGATTAACTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M32881

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_4_Locus:
8q21-q22

# Metabolic_Enzyme_4_SNPs:
rs4545; rs4544; rs6441; rs4537; rs4539; rs5312; rs6438; rs4536; rs4543; rs4538; rs5310; rs5313; rs5281; rs4546; rs3802230; rs3839864; rs3097; rs3802228; rs3201271; rs6431; rs6435; rs7461740; rs6397; rs6432; rs6429; rs11781816; rs6421; rs10107682; rs10090630; rs4072020; rs6399; rs10096239; rs6396; rs10099658; rs4736320; rs6433; rs7836572; rs13276226; rs5307; rs10099052; rs6418; rs6434; rs6416; rs10086846; rs12679242; rs6414; rs10110732; rs6415; rs11779229; rs6394; rs5306; rs6413; rs10090037; rs7463212; rs1799998; rs6471583; rs11781082; rs10087214; rs6992689; rs11991278; rs6440; rs12542987; rs5305; rs28931609; rs5315; rs5317; rs28930074; rs9297975; rs3201269; rs33921450; rs7463238; rs35574522; rs28390200; rs28491316; rs3201272; rs33936656; rs13257266; rs13268153; rs28531895; rs33911914; rs28361356; rs35733998; rs5895735; rs35490512; rs28526467; rs36018151; rs34144193; rs6436; rs28366703; rs13257680; rs1574565; rs5314; rs35909170; rs28394055; rs13263682; rs28615142; rs28497862; rs13252628; rs13257267; rs28659182; rs13268025; rs5895734; rs10956996; rs34951350; rs7463148; rs10623281; rs13254375; rs34884498; rs7464883; rs1800534; rs10096393; rs10108843; rs11775009; rs12546357; rs13267320; rs35431302; rs4379428; rs4736317; rs4736318; rs4736319; rs4736355; rs4736356; rs4736357; rs4736358; rs4736359; rs4736360; rs6471580; rs6471581; rs6471586; rs6651273; rs6981918; rs6987382; rs7004863; rs7011830; rs7011889; rs7011901; rs7016924; rs7460125; rs7819943; rs7820667; rs7821838; rs7824229; rs7828967; rs7831617; rs7844961; rs9643358

# Metabolic_Enzyme_4_General_References:
2592361; 2256920; 1594605; 1346492; 8439335; 9177280; 9625333; 9814506; 9931115; 10391209; 10391210; 11238478; 12788848

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5809

# Metabolic_Enzyme_5_Name:
Cytochrome P450 21

# Metabolic_Enzyme_5_Synonyms:
Cytochrome P450 XXI; Steroid 21- hydroxylase; 21-OHase; P450-C21; P-450c21; P450-C21B

# Metabolic_Enzyme_5_Gene_Name:
CYP21A2

# Metabolic_Enzyme_5_Protein_Sequence:
>Cytochrome P450 21
MLLLGLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYR
LHLGLQDVVV
LNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDLSLGDYSLLWKAH
KKLTRSALLLGIRDSMEPVVE
QLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFG
DKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVD
VIPFLRFFPNPGLRRLKQAIEKRDHIV
EMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGH
VHMAAVDLLIGGTETT
ANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIA
EVLRL
RPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKN
SRALA
FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQ
PFQVRLQPRGMGAHSP
GQNQ

# Metabolic_Enzyme_5_Number_of_Residues:
494

# Metabolic_Enzyme_5_Molecular_Weight:
55888

# Metabolic_Enzyme_5_Theoretical_pI:
7.90

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_5_Specific_Function:
Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids

# Metabolic_Enzyme_5_Pathway:
map00140  C21-Steroid hormone metabolism

# Metabolic_Enzyme_5_Reaction:
a steroid + AH2 + O2 = a 21-hydroxysteroid + A + H2O

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_5_Signals:
1-15

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.14.99.10

# Metabolic_Enzyme_5_GenBank_ID_Protein:
181290

# Metabolic_Enzyme_5_SwissProt_ID:
CP21A_HUMAN (P08686)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
CYP21A2

# Metabolic_Enzyme_5_Geneatlas_id:
CYP21A2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:2600

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein

# Metabolic_Enzyme_5_Gene_Sequence:
>102 bp

CGCATGAGAGCCCAGCCCGGCACCCCTGTGGCCATTGAGGAGGAATTCTCTCTCCTCAC
CTGCAGCATCA
TCTGTTACCTCACCTTCGGAGACAAGATCAAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M19711

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_5_Locus:
6p21.3

# Metabolic_Enzyme_5_SNPs:
Not Available

# Metabolic_Enzyme_5_General_References:
3487786; 3486422; 3038528; 1406709; 3871526; 3497399; 1864962; 8081391; 3257825; 2303461; 1937474; 2072928; 1644925; 1406699; 1496017; 8478006; 7749410; 9067760; 9187661; 8989258; 9580109; 9497336; 10094562; 10408778; 10408786; 10051010; 10391209; 12788866; 12915679

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
7375

# Metabolic_Enzyme_6_Name:
Superoxide dismutase [Mn], mitochondrial precursor

# Metabolic_Enzyme_6_Synonyms:
Not Available

# Metabolic_Enzyme_6_Gene_Name:
SOD2

# Metabolic_Enzyme_6_Protein_Sequence:
>Superoxide dismutase Mn, mitochondrial precursor
MLSRAVCGTSRQLAPALGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVN
NLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEA
IKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLL
GIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK

# Metabolic_Enzyme_6_Number_of_Residues:
222

# Metabolic_Enzyme_6_Molecular_Weight:
24722

# Metabolic_Enzyme_6_Theoretical_pI:
8.45

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  metal ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on superoxide radicals as acceptor
Function:  superoxide dismutase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  superoxide metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems

# Metabolic_Enzyme_6_Pathway:
Not Available

# Metabolic_Enzyme_6_Reaction:
2 O2*- + 2 H+ = O2 + H2O2

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF02777:Sod_Fe_C;
PF00081:Sod_Fe_N

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.15.1.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
34709

# Metabolic_Enzyme_6_SwissProt_ID:
SODM_HUMAN (P04179)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
SOD2

# Metabolic_Enzyme_6_Geneatlas_id:
SOD2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:11180

# Metabolic_Enzyme_6_PDB_ID:
1LUV

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_6_Gene_Sequence:
>669 bp
ATGTTGAGCCGGGCAGTGTGCGGCACCAGCAGGCAGCTGGCTCCGGCTTTGGGGTATCTG
GGCTCCAGGCAGAAGCACAGCCTCCCCGACCTGCCCTACGACTACGGCGCCCTGGAACCT
CACATCAACGCGCAGATCATGCAGCTGCACCACAGCAAGCACCACGCGGCCTACGTGAAC
AACCTGAACGTCAACGAGGAGAAGTACCAGGAGGCGTTGGCCAAGGGAGATGTTACAGCC
CAGATAGCTCTTCAGCCTGCACTGAAGTTCAATGGTGGTGGTCATATCAATCATAGCATT
TTCTGGACAAACCTCAGCCCTAACGGTGGTGGAGAACCCAAAGGGGAGTTGCTGGAAGCC
ATCAAACGTGACTTTGGTTCCTTTGACAAGTTTAAGGAGAAGCTGACGGCTGCATCTGTT
GGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAACGGGGACACTTACAA
ATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTG
GGGATTGATGTGTGGGAGCACGCTTACTACCTTCAGTATAAAAATGTCAGGCCTGATTAT
CTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAAGATACATGGCTTGC
AAAAAGTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
X59445

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_6_Locus:
6q25.3

# Metabolic_Enzyme_6_SNPs:
Not Available

# Metabolic_Enzyme_6_General_References:
2462451; 3684581; 3399391; 2831093; 1988135; 1699607; 7702755; 14574404; 6386798; 7895732; 7498159; 9150946; 1394426; 8605177; 9537988; 9537987; 10852710; 11580280

# Metabolic_Enzyme_6_References:
12600921; 12925450; 15124912

# Metabolic_Enzyme_7_ID:
8038

# Metabolic_Enzyme_7_Name:
Neprilysin

# Metabolic_Enzyme_7_Synonyms:
Neutral endopeptidase; NEP; Enkephalinase; Neutral endopeptidase 24.11; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; CD10 antigen

# Metabolic_Enzyme_7_Gene_Name:
MME

# Metabolic_Enzyme_7_Protein_Sequence:
>Neprilysin
MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW

# Metabolic_Enzyme_7_Number_of_Residues:
750

# Metabolic_Enzyme_7_Molecular_Weight:
85515

# Metabolic_Enzyme_7_Theoretical_pI:
5.43

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  endopeptidase activity
Function:  metalloendopeptidase activity
Function:  neprilysin activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  metallopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_7_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_7_Specific_Function:
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Involved in the degradation of atrial natriuretic factor (ANF)

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF01431:Peptidase_M13;
PF05649:Peptidase_M13_N

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
29-51

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.4.24.11

# Metabolic_Enzyme_7_GenBank_ID_Protein:
34758

# Metabolic_Enzyme_7_SwissProt_ID:
NEP_HUMAN (P08473)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
MME

# Metabolic_Enzyme_7_Geneatlas_id:
MME

# Metabolic_Enzyme_7_hgnc_id:
HGNC:7154

# Metabolic_Enzyme_7_PDB_ID:
1DMT

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_7_Gene_Sequence:
>2232 bp
ATGGATATAACTGATATCAACACTCCAAAGCCAAAGAAGAAACAGCGATGGACTCCACTG
GAGATCAGCCTCTCGGTCCTTGTCCTGCTCCTCACCATCATAGCTGTGACAATGATCGCA
CTCTATGCAACCTACGATGATGGTATTTGCAAGTCATCAGACTGCATAAAATCAGCTGCT
CGACTGATCCAAAACATGGATGCCACCACTGAGCCTTGTACAGACTTTTTCAAATATGCT
TGCGGAGGCTGGTTGAAACGTAATGTCATTCCCGAGACCAGCTCCCGTTACGGCAACTTT
GACATTTTAAGAGATGAACTAGAAGTCGTTTTGAAAGATGTCCTTCAAGAACCCAAAACT
GAAGATATAGTAGCAGTGCAGAAAGCAAAAGCATTGTACAGGTCTTGTATAAATGAATCT
GCTATTGATAGCAGAGGTGGAGAACCTCTACTCAAACTGTTACCAGACATATATGGGTGG
CCAGTAGCAACAGAAAACTGGGAGCAAAAATATGGTGCTTCTTGGACAGCTGAAAAAGCT
ATTGCACAACTGAATTCTAAATATGGGAAAAAAGTCCTTATTAATTTGTTTGTTGGCACT
GATGATAAGAATTCTGTGAATCATGTAATTCATATTGACCAACCTCGACTTGGCCTCCCT
TCTAGAGATTACTATGAATGCACTGGAATCTATAAAGAGGCTTGTACAGCATATGTGGAT
TTTATGATTTCTGTGGCCAGATTGATTCGTCAGGAAGAAAGATTGCCCATCGATGAAAAC
CAGCTTGCTTTGGAAATGAATAAAGTTATGGAATTGGAAAAAGAAATTGCCAATGCTACG
GCTAAACCTGAAGATCGAAATGATCCAATGCTTCTGTATAACAAGATGACATTGGCCCAG
ATCCAAAATAACTTTTCACTAGAGATCAATGGGAAGCCATTCAGCTGGTTGAATTTCACA
AATGAAATCATGTCAACTGTGAATATTAGTATTACAAATGAGGAAGATGTGGTTGTTTAT
GCTCCAGAATATTTAACCAAACTTAAGCCCATTCTTACCAAATATTCTGCCAGAGATCTT
CAAAATTTAATGTCCTGGAGATTCATAATGGATCTTGTAAGCAGCCTCAGCCGAACCTAC
AAGGAGTCCAGAAATGCTTTCCGCAAGGCCCTTTATGGTACAACCTCAGAAACAGCAACT
TGGAGACGTTGTGCAAACTATGTCAATGGGAATATGGAAAATGCTGTGGGGAGGCTTTAT
GTGGAAGCAGCATTTGCTGGAGAGAGTAAACATGTGGTCGAGGATTTGATTGCACAGATC
CGAGAAGTTTTTATTCAGACTTTAGATGACCTCACTTGGATGGATGCCGAGACAAAAAAG
AGAGCTGAAGAAAAGGCCTTAGCAATTAAAGAAAGGATCGGCTATCCTGATGACATTGTT
TCAAATGATAACAAACTGAATAATGAGTACCTCGAGTTGAACTACAAAGAAGATGAATAC
TTCGAGAACATAATTCAAAATTTGAAATTCAGCCAAAGTAAACAACTGAAGAAGCTCCGA
GAAAAGGTGGACAAAGATGAGTGGATAAGTGGAGCAGCTGTAGTCAATGCATTTTACTCT
TCAGGAAGAAATCAGATAGTCTTCCCAGCCGGCATTCTGCAGCCCCCCTTCTTTAGTGCC
CAGCAGTCCAACTCATTGAACTATGGGGGCATCGGCATGGTCATAGGACACGAAATCACC
CATGGCTTCGATGACAATGGCAGAAACTTTAACAAAGATGGAGACCTCGTTGACTGGTGG
ACTCAACAGTCTGCAAGTAACTTTAAGGAGCAATCCCAGTGCATGGTGTATCAGTATGGA
AACTTTTCCTGGGACCTGGCAGGTGGACAGCACCTTAATGGAATTAATACACTGGGAGAA
AACATTGCTGATAATGGAGGTCTTGGTCAAGCATACAGAGCCTATCAGAATTATATTAAA
AAGAATGGCGAAGAAAAATTACTTCCTGGACTTGACCTAAATCACAAACAACTATTTTTC
TTGAACTTTGCACAGGTGTGGTGTGGAACCTATAGGCCAGAGTATGCGGTTAACTCCATT
AAAACAGATGTGCACAGTCCAGGCAATTTCAGGATTATTGGGACTTTGCAGAACTCTGCA
GAGTTTTCAGAAGCCTTTCACTGCCGCAAGAATTCATACATGAATCCAGAAAAGAAGTGC
CGGGTTTGGTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
X07166

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_7_Locus:
3q25.1-q25.2

# Metabolic_Enzyme_7_SNPs:
rs35227300; rs35926730; rs701109; rs7610758; rs12765; rs6794748; rs6665; rs989692; rs3821717; rs1042343; rs1126662; rs3773905; rs9829757; rs968628; rs1436633; rs1025192; rs2118073; rs3773882; rs1807004; rs9881879; rs3773885; rs3773880; rs1807003; rs9849573; rs3773901; rs4679739; rs9847553; rs9830725; rs7649252; rs12493021; rs3796268; rs6440966; rs1370031; rs9853221; rs7431115; rs2196521; rs9827586; rs1436631; rs1836917; rs2016846; rs1436635; rs9846938; rs1836915; rs3773899; rs1385480; rs3773888; rs4273335; rs12696022; rs3821719; rs2007329; rs1812652; rs3773871; rs6804570; rs17383987; rs9832950; rs3736187; rs1436634; rs9829347; rs10804768; rs3773889; rs16824591; rs3773896; rs4607069; rs3773877; rs7433648; rs10513470; rs3773891; rs7618860; rs3773872; rs9864287; rs3816801; rs3816803; rs3773898; rs4273336; rs10513469; rs3773904; rs13086740; rs16824641; rs3732886; rs3773893; rs17443031; rs3773902; rs17449556; rs6800145; rs1816558; rs3773876; rs3773895; rs16824656; rs6776185; rs10513468; rs4405870; rs2016848; rs1436632; rs11719420; rs10804769; rs6801319; rs13077421; rs17442808; rs9831947; rs3773892; rs3736188; rs16824574; rs9713010; rs12489807; rs3821721; rs3773903; rs12635515; rs12490001; rs11713572; rs9867821; rs1836916; rs4611779; rs9864538; rs6763852; rs12496460; rs6773791; rs12638172; rs16824625; rs1436630; rs12495564; rs6798179; rs12632714; rs7626010; rs7633993; rs6801276; rs7629378; rs6763919; rs9856798; rs9289951; rs16824618; rs9713472; rs16824575; rs9839250; rs17384425; rs9827313; rs10935999; rs7639923; rs3773873; rs16824555; rs3732888; rs9874608; rs3773886; rs3836434; rs6797911; rs7639962; rs16824626; rs9834487; rs12638175; rs6804455; rs7625009; rs9819906; rs7648334; rs6785920; rs16824648; rs1385479; rs16824551; rs9713011; rs3773887; rs13065680; rs16824562; rs3773881; rs3773884; rs10935998; rs16824558; rs3773878; rs16824623; rs3773874; rs9876965; rs9844438; rs11925306; rs3836436; rs9854218; rs1836914; rs3773906; rs3773907; rs1042290; rs41267905; rs34931605; rs1062488; rs1126608; rs1062487; rs35152996; rs34147103; rs3213879; rs1042305; rs1803235; rs1042301; rs10611660; rs7648713; rs1042326; rs28673360; rs1042342; rs34385388; rs12176; rs34877913; rs35599824; rs4571206; rs6764041; rs35578452; rs16824596; rs3796267; rs34745881; rs28788259; rs28691749; rs34979254; rs7633703; rs34673569; rs35794019; rs35421413; rs35213254; rs9882981; rs35749393; rs3816802; rs28778887; rs10935997; rs13066247; rs35014314; rs35628546; rs7626284; rs1485239; rs2164555; rs28617565; rs9841712; rs10664276; rs11300412; rs16824559; rs6792240; rs41485544; rs35070142; rs12493386; rs2304504; rs17450609; rs11464401; rs11349976; rs34177891; rs34078518; rs5853716; rs41267911; rs41267907; rs11403666; rs35608418; rs9713095; rs35589959; rs28841298; rs36097668; rs35748450; rs34292929; rs11359933; rs9874874; rs11710357; rs11391196; rs1280064; rs3836437; rs4629293; rs35273441; rs16824569; rs36115413; rs35131344; rs35200999; rs35351972; rs3836439; rs2011753; rs10620895; rs6801016; rs35142333; rs28417610; rs13066242; rs11296151; rs35030915; rs35089203; rs33917850; rs12491360; rs10622201; rs12053875; rs41267903; rs34121569; rs13434182; rs5853713; rs6799300; rs34540478; rs16824635; rs9874896; rs12629968; rs11406128; rs11448605; rs5853715; rs34319615; rs11373874; rs1299661; rs34922274; rs13093233; rs28878180; rs28787412; rs4467412; rs35507229; rs3172398; rs35688638; rs35948931; rs16824624; rs36013310; rs35482420; rs3773879; rs9843813; rs10706442; rs35991584; rs5853712; rs28825395; rs7627068; rs33959610; rs16846958; rs11359866; rs35708164; rs9870542; rs11445808; rs35653282; rs34549615; rs13070260; rs9819744; rs2196522; rs11344677; rs10620043; rs3839085; rs13093231; rs3773890; rs5853714; rs6797549; rs11340092; rs33979604; rs41267909; rs13071013; rs10522735; rs3836438; rs36167758; rs9869317; rs11303845; rs4680153; rs13070729; rs13073702; rs4377457; rs35330405; rs10706860; rs28758831; rs3836433; rs34814906; rs36037593; rs9825415; rs35450782; rs5853711; rs9864458; rs35994024; rs1836913; rs1836912; rs9809268; rs35309296; rs35900633; rs5853710; rs34585642; rs35303134; rs1021216; rs13081581; rs1385475; rs1385476; rs1385477; rs16824536; rs16824538; rs16824540; rs16846960; rs4345034; rs6805925; rs7622933; rs7627426; rs7649865; rs9851460; rs9866659

# Metabolic_Enzyme_7_General_References:
3162217; 2971756; 2968607; 2528730; 8168535; 12754519; 10669592

# Metabolic_Enzyme_7_References:
8064160

# Macromolecular_Interacting_Partner_1_ID:
7542

# Macromolecular_Interacting_Partner_1_Name:
Kininogen-1 precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Alpha-2-thiol proteinase inhibitor[Contains: Kininogen-1 heavy chain; Bradykinin; Kallidin I; Lysyl-bradykinin; Kallidin II; Kininogen-1 light chain; Low molecular weight growth- promoting factor]

# Macromolecular_Interacting_Partner_1_Gene_Name:
KNG1

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Kininogen1 precursor
MKLITILFLCSRLLLSLTQESQSEEIDCNDKDLFKAVDAALKKYNSQNQSNNQFVLYRIT
EATKTVGSDTFYSFKYEIKEGDCPVQSGKTWQDCEYKDAAKAATGECTATVGKRSSTKFS
VATQTCQITPAEGPVVTAQYDCLGCVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLN
EVKRAQRQVVAGLNFRITYSIVQTNCSKENFLFLTPDCKSLWNGDTGECTDNAYIDIQLR
IASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTNSPELEETLTHTITKLNAENNATFYFK
IDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETKKLGQSLDCNAEVYVVPW
EKKIYPTVNCQPLGMISLMKRPPGFSPFRSSRIGEIKEETTVSPPHTSMAPAQDEERDSG
KEQGHTRRHDWGHEKQRKHNLGHGHKHERDQGHGHQRGHGLGHGHEQQHGLGHGHKFKLD
DDLEHQGGHVLDHGHKHKHGHGHGKHKNKGKKNGKHNGWKTEHLASSSEDSTTPSAQTQE
KTEGPTPIPSLAKPGVTVTFSDFQDSDLIATMMPPISPAPIQSDDDWIPDIQIDPNGLSF
NPISDFPDTTSPKCPGRPWKSVSEINPTTQMKESYYFDLTDGLS

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
644

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
71958

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.80

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  protease inhibitor activity
Function:  endopeptidase inhibitor activity
Function:  cysteine protease inhibitor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects:(4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00031:Cystatin

# Macromolecular_Interacting_Partner_1_Signals:
1-18

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
177890

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
KNG1_HUMAN (P01042)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
KNG1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
KNG1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6383

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein; extracellular space

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1284 bp
ATGAAACTAATTACCATCCTTTTCCTCTGCTCCAGGCTACTACTAAGTTTAACCCAGGAA
TCACAGTCCGAGGAAATTGACTGCAATGACAAGGATTTATTTAAAGCTGTGGATGCTGCT
CTGAAGAAATATAACAGTCAAAACCAAAGTAACAACCAGTTTGTATTGTACCGCATAACT
GAAGCCACTAAGACGGTTGGCTCTGACACGTTTTATTCCTTCAAGTACGAAATCAAGGAG
GGGGATTGTCCTGTTCAAAGTGGCAAAACCTGGCAGGACTGTGAGTACAAGGATGCTGCA
AAAGCAGCCACTGGAGAATGCACGGCAACCGTGGGGAAGAGGAGCAGTACGAAATTCTCC
GTGGCTACCCAGACCTGCCAGATTACTCCAGCCGAGGGCCCTGTGGTGACAGCCCAGTAC
GACTGCCTCGGCTGTGTGCATCCTATATCAACGCAGAGCCCAGACCTGGAGCCCATTCTG
AGACACGGCATTCAGTACTTTAACAACAACACTCAACATTCCTCCCTCTTCATGCTTAAT
GAAGTAAAACGGGCCCAAAGACAGGTGGTGGCTGGATTGAACTTTCGAATTACCTACTCA
ATTGTGCAAACGAATTGTTCCAAAGAGAATTTTCTGTTCTTAACTCCAGACTGCAAGTCC
CTTTGGAATGGTGATACCGGTGAATGTACAGATAATGCATACATCGATATTCAGCTACGA
ATTGCTTCCTTCTCACAGAACTGTGACATTTATCCAGGGAAGGATTTTGTACAACCACCT
ACCAAGATTTGCGTGGGCTGCCCCAGAGATATACCCACCAACAGCCCAGAGCTGGAGGAG
ACACTGACTCACACCATCACAAAGCTTAATGCAGAGAATAACGCAACTTTCTATTTCAAG
ATTGACAATGTGAAAAAAGCAAGAGTACAGGTGGTGGCTGGCAAGAAATATTTTATTGAC
TTCGTGGCCAGGGAAACCACATGTTCCAAGGAAAGTAATGAAGAGTTGACCGAAAGCTGT
GAGACCAAAAAACTTGGCCAAAGCCTAGATTGCAACGCTGAAGTTTATGTGGTACCCTGG
GAGAAAAAAATTTACCCTACTGTCAACTGTCAACCACTGGGAATGATCTCACTGATGAAA
AGGCCTCCAGGTTTTTCACCTTTCCGATCATCACGAATAGGGGAAATAAAAGAAGAAACA
ACTAGTCACCTAAGGTCCTGCGAGTACAAGGGTCGACCCCCAAAGGCAGGGGCAGAGCCA
GCATCTGAGAGGGAGGTCTCTTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
K02566

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_1_Locus:
3q27

# Macromolecular_Interacting_Partner_1_SNPs:
rs2304456; rs5030024; rs1656922; rs5030015; rs1469859; rs5029980; rs1050274; rs5030096; rs5029974; rs1656925; rs2378115; rs1648698; rs5030072; rs710448; rs266760; rs1648697; rs5030022; rs1624569; rs5030023; rs5030002; rs5029999; rs5029979; rs5030020; rs5030094; rs1648722; rs1656914; rs698078; rs1851665; rs5030057; rs5030039; rs5029988; rs5030032; rs1656912; rs5030045; rs5030095; rs1829886; rs1656918; rs5030103; rs1851664; rs5030087; rs5030018; rs5030063; rs1648715; rs5030089; rs5029991; rs4686798; rs1656921; rs5030107; rs5029985; rs5029990; rs1656942; rs1624230; rs1622922; rs5030053; rs5030106; rs1648700; rs5030052; rs5029986; rs822366; rs5030076; rs5030092; rs5030059; rs710449; rs5029992; rs5030011; rs5030069; rs5030043; rs5030028; rs710447; rs5030111; rs3190571; rs822363; rs2689197; rs5030004; rs1621816; rs5030083; rs710446; rs5030051; rs2651640; rs1648716; rs5029987; rs5030033; rs1656910; rs1403694; rs1648712; rs166479; rs7644084; rs1836860; rs5030081; rs5030113; rs5030084; rs1656917; rs822620; rs822624; rs2304451; rs5030068; rs822364; rs5030048; rs5030041; rs266724; rs5030090; rs5030108; rs5030074; rs2304452; rs5030037; rs5030026; rs5030001; rs5030082; rs5030049; rs3841557; rs1656909; rs5030042; rs1656926; rs5030079; rs5030035; rs1656911; rs1648711; rs2062632; rs822362; rs5030031; rs5030025; rs1656920; rs5030088; rs5030012; rs5030085; rs266725; rs5030075; rs5029981; rs3856930; rs1648714; rs5030102; rs5030017; rs5030064; rs5030066; rs5030065; rs5029976; rs5030003; rs4686439; rs5030029; rs5030046; rs5030038; rs5030009; rs5029997; rs4686799; rs2651641; rs1656908; rs5030061; rs5030014; rs5030115; rs5030086; rs1656919; rs1656916; rs5030016; rs5030060; rs5029982; rs5029989; rs5029996; rs5030047; rs5030093; rs5030058; rs5030070; rs5029993; rs1648699; rs5029977; rs5030067; rs1648713; rs2304455; rs5029998; rs5030091; rs266723; rs5030044; rs5030109; rs5030104; rs5030062; rs5030050; rs5030073; rs5029978; rs1656915; rs5030027; rs5030099; rs5029994; rs5030036; rs13317089; rs11917445; rs5030071; rs5030078; rs5030054; rs5030080; rs5030112; rs1523435; rs5029975; rs2304454; rs5029995; rs865880; rs5030101; rs5029983; rs5030105; rs5030056; rs5030034; rs5030019; rs5030008; rs266726; rs9869244; rs5030077; rs4686800; rs11929295; rs5030100; rs5030021; rs5030013; rs5030114; rs13084325; rs5030055; rs9882598; rs5030000; rs5030110; rs13098645; rs10440056; rs3774291; rs2651639; rs5029973; rs5029970; rs3806688; rs5029969; rs3774292; rs3821815; rs3806689; rs5029971; rs10439971; rs17838879; rs10440057; rs5029972; rs10439970; rs33934143; rs13072823; rs36121564; rs9866324; rs11328552; rs28461768; rs11276552; rs28607874; rs35578318; rs1212217; rs34098137; rs10571187; rs822365; rs35995617; rs10531727; rs11425592; rs11425593; rs35477316; rs35079146; rs34693243; rs13095338; rs1209472; rs34650598; rs13062473; rs28496811; rs13072436; rs35957661; rs10575985; rs13072694; rs34231414; rs9877452; rs10703695; rs10575988; rs10576660; rs34707597; rs34208952; rs35394339; rs11275829; rs11057; rs11328550; rs10662949; rs9818796; rs34957759; rs1656927; rs9825929; rs12635879; rs35569041; rs13063282; rs2912567; rs34651871; rs1211468; rs28390219; rs9819941; rs10575986; rs13095484; rs2304453; rs9851780; rs11328551; rs35025634; rs5030030; rs192371; rs13083619; rs35668151; rs35596301; rs13085884; rs13072546; rs9812764; rs11394050; rs3217421; rs13072563; rs35138120; rs34745532; rs13065593; rs10575987; rs35823469; rs34728507; rs35667207; rs10571591; rs35425194; rs2651642; rs35065127; rs3836479; rs10702686; rs11297934; rs1648717; rs36160200; rs10513803; rs10937264; rs10937265; rs10937266; rs11712801; rs11918289; rs11924390; rs11927941; rs12491806; rs12497377; rs12629364; rs13098570; rs13315296; rs1392952; rs1656939; rs1656940; rs1656966; rs1972703; rs2033122; rs266721; rs266722; rs266762; rs266763; rs266764; rs266767; rs34358682; rs35557208; rs35853604; rs4615069; rs4686436; rs5030097; rs5030098; rs6796803; rs6807774; rs7624355; rs7647509; rs822368; rs822370; rs822371; rs822373; rs905056; rs905057; rs961010; rs9817038; rs9838998; rs9852828

# Macromolecular_Interacting_Partner_1_General_References:
6441591; 2989293; 4054110; 4952632; 3484703; 3366244; 7589467; 2989294; 3182782; 12754519

# Macromolecular_Interacting_Partner_1_References:
1281379; 8904078; 9622142; 9638501

# Macromolecular_Interacting_Partner_2_ID:
7191

# Macromolecular_Interacting_Partner_2_Name:
Vasopressin-neurophysin 2-copeptin precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
AVP-NPII[Contains: Arg-vasopressin; Neurophysin 2; Neurophysin-II; Copeptin]

# Macromolecular_Interacting_Partner_2_Gene_Name:
AVP

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Vasopressinneurophysin 2copeptin precursor
MPDTMLPACFLGLLAFSSACYFQNCPRGGKRAMSDLELRQCLPCGPGGKGRCFGPSICCA
DELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAAFGVCCNDESCVTEPECREGF
HRRARASDRSNATQLDGPAGALLLRLVQLAGAPEPFEPAQPDAY

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
164

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
17325

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
4.94

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
Function:  neuropeptide hormone activity
Function:  neurohypophyseal hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00220:Hormone_4;
PF00184:Hormone_5

# Macromolecular_Interacting_Partner_2_Signals:
1-19

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
340303

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
NEU2_HUMAN (P01185)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
AVP

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
AVP

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:894

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>495 bp
ATGCCTGACACCATGCTGCCCGCCTGCTTCCCTGGCCTACTGGCCTTCTCCTCCGCGTGC
TACTTCCAGAACTGCCCGAGGGGCGGCAAGAGGGCCATGTCCGACCTGGAGCTGAGACAG
TGCCTCCCCTGCGGCCCCGGGGGCAAAGGCCGCTGCTTCGGGCCCAGCATCTGCTGCGCG
GACGAGCTGGGCTGCTTCGTGGGCACGGCTGAGGCGCTGCGCTGCCAGGAGGAGAACTAC
CTGCCGTCGCCCTGCCAGTCCGGCCAGAAGGCGTGCGGGAGCGGGGGCCGCTGCGCCGCC
TTCGGCGTTTGCTGCAACGACGAGAGCTGCGTGACCGAGCCCGAGTGCCGCGAGGGCTTT
CACCGCCGCGCCCGCGCCAGCGACCGGAGCAACGCCACGCAGCTGGACGGGCCGGCCGGG
GCCTTGCTGCTGCGGCTGGTGCAGCTGGCCGGGGCGCCCGAGCCCTTCGAGCCCGCCCAG
CCCGACGCCTACTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M11166

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_2_Locus:
20p13

# Macromolecular_Interacting_Partner_2_SNPs:
rs5195; rs2282018; rs3787482; rs2740204; rs2770381; rs2740185; rs6037481; rs3761249; rs3729965; rs6115785; rs1887854; rs11697831; rs1051744; rs28934878; rs13041277; rs13041150; rs13041148; rs3729964; rs1051747; rs13041122; rs1051748; rs1051746; rs6115784; rs2740190; rs11482923; rs13037218; rs4815565; rs34852810; rs7362057; rs2770380; rs1410713; rs2740188; rs2740207; rs2740208; rs2740210; rs2770378; rs4813627; rs6037478; rs6051572; rs6051578; rs6084265

# Macromolecular_Interacting_Partner_2_General_References:
2991279; 3768139; 4065330; 1740104; 11780052; 6574452; 7271787; 8370682; 8103767; 8514868; 8045958; 7714110; 8554046; 9360520; 9580132; 9814475; 10369876; 11017955; 11150885; 10677561; 11748489; 11161827; 11980620; 12012274; 12107248; 12359138; 12519420

# Macromolecular_Interacting_Partner_2_References:
12072411

# Macromolecular_Interacting_Partner_3_ID:
7197

# Macromolecular_Interacting_Partner_3_Name:
Corticotropin-lipotropin precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
Pro-opiomelanocortin; POMC[Contains: NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin]

# Macromolecular_Interacting_Partner_3_Gene_Name:
POMC

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Corticotropinlipotropin precursor
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
267

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
29424

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Beta-endorphin and Met-enkephalin are endogenous opiates

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00976:ACTH_domain;
PF08384:NPP;
PF08035:Op_neuropeptide

# Macromolecular_Interacting_Partner_3_Signals:
1-26

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
190188

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
COLI_HUMAN (P01189)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
POMC

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
POMC

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:9201

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>789 bp
TGCAGCCGCTCGGGGGCCCTGTTGCTGGCCTTGCTGCTTCAGGCCTCCATGGAAGTGCGT
GGCTGGTGCCTGGAGAGCAGCCAGTGTCAGGACCTCACCACGGAAAGCAACCTGCTGGAG
TGCATCCGGGCCTGCAAGCCCGACCTCTCGGCCGAGACTCCCATGTTCCCGGGAAATGGC
GACGAGCAGCCTCTGACCGAGAACCCCCGGAAGTACGTCATGGGCCACTTCCGCTGGGAC
CGATTCGGCCGCCGCAACAGCAGCAGCAGCGGCAGCAGCGGCGCAGGGCAGAAGCGCGAG
GACGTCTCAGCGGGCGAAGACTGCGGCCCGCTGCCTGAGGGCGGCCCCGAGCCCCGCAGC
GATGGTGCCAAGCCGGGCCCGCGCGAGGGCAAGCGCTCCTACTCCATGGAGCACTTCCGC
TGGGGCAAGCCGGTGGGCAAGAAGCGGCGCCCAGTGAAGGTGTACCCTAACGGCGCCGAG
GACGAGTCGGCCGAGGCCTTCCCCCTGGAGTTCAAGAGGGAGCTGACTGGCCAGCGACTC
CGGGAGGGAGATGGCCCCGACGGCCCTGCCGATGACGGCGCAGGGGCCCAGGCCGACCTG
GAGCACAGCCTGCTGGTGGCGGCCGAGAAGAAGGACGAGGGCCCCTACAGGATGGAGCAC
TTCCGCTGGGGCAGCCCGCCCAAGGACAAGCGCTACGGCGGTTTCATGACCTCCGAGAAG
AGCCAGACGCCCCTGGTGACGCTGTTCAAAAACGCCATCATCAAGAACGCCTACAAGAAG
GGCGAGTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
M38297

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_3_Locus:
2p23.3

# Macromolecular_Interacting_Partner_3_SNPs:
rs28932472; rs8192606; rs28932471; rs35254395; rs8192605; rs28930368; rs2071345; rs34650613; rs1042571; rs11679531; rs6713532; rs7565877; rs6713396; rs12473543; rs6756695; rs6545975; rs6756566; rs28932474; rs28932476; rs28932475; rs28932473; rs10654394; rs28932470; rs3039380; rs35411223; rs35023083; rs33950052; rs7591899; rs15461; rs2071344; rs13388660; rs9973478; rs11353932; rs13404336; rs7565427; rs34619618; rs8192607; rs35639116; rs34526166; rs10188864; rs10195561; rs11892647; rs12472851; rs13418937; rs17046887; rs17046891; rs1866146; rs2071343; rs2118404; rs2164808; rs3769671; rs3795955; rs3820935; rs6545976; rs6719226; rs6734859; rs7589318; rs7605927; rs934778

# Macromolecular_Interacting_Partner_3_General_References:
6274691; 6299668; 6314261; 3606677; 6254047; 6945581; 6267033; 6272808; 4352834; 4334191; 4338630; 4347148; 1264228; 195688; 2424570; 2839146; 7828531; 9768693; 10193875; 11244459

# Macromolecular_Interacting_Partner_3_References:
10437805; 1322161; 1354078; 1531483

# Macromolecular_Interacting_Partner_4_ID:
7549

# Macromolecular_Interacting_Partner_4_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
INS

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_4_Signals:
1-24

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
INS

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_4_Locus:
11p15.5

# Macromolecular_Interacting_Partner_4_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_4_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_4_References:
1296859; 1481903; 15898729

# Macromolecular_Interacting_Partner_5_ID:
7556

# Macromolecular_Interacting_Partner_5_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_5_Signals:
1-18

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_5_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_5_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_5_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_5_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_5_References:
11244026; 2018930; 8039844

# Macromolecular_Interacting_Partner_6_ID:
5998

# Macromolecular_Interacting_Partner_6_Name:
Cytochrome P450 11A1, mitochondrial precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
CYPXIA1; P450(scc; Cholesterol side-chain cleavage enzyme; Cholesterol desmolase

# Macromolecular_Interacting_Partner_6_Gene_Name:
CYP11A1

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Cytochrome P450 11A1, mitochondrial precursor
MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWL
NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPER
FLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVS
VLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQM
FHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRG
ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR
HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIY
ALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML
ENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
521

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
60103

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
9.18

# Macromolecular_Interacting_Partner_6_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Macromolecular_Interacting_Partner_6_Specific_Function:
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone

# Macromolecular_Interacting_Partner_6_Pathway:
map00140  C21-Steroid hormone metabolism

# Macromolecular_Interacting_Partner_6_Reaction:
cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
EC 1.14.15.6

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
181376

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
CP11A_HUMAN (P05108)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
CYP11A1

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
CYP11A1

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:2590

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Mitochondrion

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1566 bp
ATGCTGGCCAAGGGTCTTCCCCCACGCTCAGTCCTGGTCAAAGGCTACCAGACCTTTCTG
AGTGCCCCCAGGGAGGGGCTGGGGCGTCTCAGGGTGCCCACTGGCGAGGGAGCTGGCATC
TCCACCCGCAGTCCTCGCCCCTTCAATGAGATCCCCTCTCCTGGTGACAATGGCTGGCTA
AACCTGTACCATTTCTGGAGGGAGACGGGCACACACAAAGTCCACCTTCACCATGTCCAG
AATTTCCAGAAGTATGGCCCGATTTACAGGGAGAAGCTCGGCAACGTGGAGTCGGTTTAT
GTCATCGACCCTGAAGATGTGGCCCTTCTCTTTAAGTCCGAGGGCCCCAACCCAGAACGA
TTCCTCATCCCGCCCTGGGTCGCCTATCACCAGTATTACCAGAGACCCATAGGAGTCCTG
TTGAAGAAGTCGGCAGCCTGGAAGAAAGACCGGGTGGCCCTGAACCAGGAGGTGATGGCT
CCAGAGGCCACCAAGAACTTTTTGCCCCTGTTGGATGCAGTGTCTCGGGACTTCGTCAGT
GTCCTGCACAGGCGCATCAAGAAGGCGGGCTCCGGAAATTACTCGGGGGACATCAGTGAT
GACCTGTTCCGCTTTGCCTTTGAGTCCATCACTAACGTCATTTTTGGGGAGCGCCAGGGG
ATGCTGGAGGAAGTAGTGAACCCCGAGGCCCAGCGATTCATTGATGCCATCTACCAGATG
TTCCACACCAGCGTCCCCATGCTCAACCTTCCCCCAGACCTGTTCCGTCTGTTCAGGACC
AAGACCTGGAAGGACCATGTGGCTGCATGGGACGTGATTTTCAGTAAAGCTGACATATAC
ACCCAGAACTTCTACTGGGAATTGAGACAGAAAGGAAGTGTTCACCACGATTACCGTGGC
ATGCTCTACAGACTCCTGGGAGACAGCAAGATGTCCTTCGAGGACATCAAGGCCAACGTC
ACAGAGATGCTGGCAGGAGGGGTGGACACGACGTCCATGACCCTGCAGTGGCACTTGTAT
GAGATGGCACGCAACCTGAAGGTGCAGGATATGCTGCGGGCAGAGGTCTTGGCTGCGCGG
CACCAGGCCCAGGGAGACATGGCCACGATGCTACAGCTGGTCCCCCTCCTCAAAGCCAGC
ATCAAGGAGACACTAAGACTTCACCCCATCTCCGTGACCCTGCAGAGATATCTTGTAAAT
GACTTGGTTCTTCGAGATTACATGATTCCTGCCAAGACACTGGTGCAAGTGGCCATCTAT
GCTCTGGGCCGAGAGCCCACCTTCTTCTTCGACCCGGAAAATTTTGACCCAACCCGATGG
CTGAGCAAAGACAAGAACATCACCTACTTCCGGAACTTGGGCTTTGGCTGGGGTGTGCGG
CAGTGTCTGGGACGGCGGATCGCTGAGCTAGAGATGACCATCTTCCTCATCAATATGCTG
GAGAACTTCAGAGTTGAAATCCAACACCTCAGCGATGTGGGCACCACATTCAACCTCATT
CTGATGCCTGAAAAGCCCATCTCCTTCACCTTCTGGCCCTTTAACCAGGAAGCAACCCAG
CAGTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
M14565

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:15

# Macromolecular_Interacting_Partner_6_Locus:
15q23-q24

# Macromolecular_Interacting_Partner_6_SNPs:
rs6161; rs6160; rs4986873; rs2279357; rs1484215; rs11632698; rs11638442; rs12916123; rs4886594; rs1843090; rs6495096; rs41548820; rs7175214; rs2930299; rs41563614; rs41553712; rs17515476; rs12898858; rs12917295; rs2959021; rs41553612; rs41556119; rs7173655; rs7181332; rs900798; rs2073475; rs4887139; rs1049968; rs1130843; rs11544450; rs1130841; rs1132670; rs35048801; rs28671731; rs41543514; rs35153064; rs7177102; rs34371865; rs41556118; rs4887138; rs34304260; rs41543216; rs2930307; rs35856463; rs41546519; rs28681535; rs34637683; rs12442401; rs11350546; rs4640133; rs2959020; rs41550215; rs34223131; rs10635828; rs36133203; rs10644492; rs10645960; rs3831490; rs34886193; rs17522870; rs11633031; rs11635047; rs12438594; rs12899286; rs12899703; rs12900028; rs12917557; rs1564782; rs16968477; rs16968478; rs2170875; rs2277601; rs2277602; rs2277603; rs2277604; rs2277605; rs2277606; rs2279356; rs2930305; rs2930306; rs2959002; rs2959003; rs2959004; rs3803463; rs3825944; rs4077581; rs4077582; rs4077583; rs4077584; rs4077585; rs4278698; rs4432229; rs4886595; rs4887136; rs4887137; rs7163952; rs7164328; rs7174179; rs8031424; rs8034118; rs8039957; rs900802; rs9806234

# Macromolecular_Interacting_Partner_6_General_References:
3024157; 3038854; 1849407; 2419119; 10391209; 11502818; 12161514

# Macromolecular_Interacting_Partner_6_References:
2052554; 8243798

# Macromolecular_Interacting_Partner_7_ID:
7570

# Macromolecular_Interacting_Partner_7_Name:
Endothelin-1 precursor

# Macromolecular_Interacting_Partner_7_Synonyms:
Preproendothelin-1; PPET1[Contains: Endothelin-1; ET-1; Big endothelin-1]

# Macromolecular_Interacting_Partner_7_Gene_Name:
EDN1

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Endothelin1 precursor
MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMD
KECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCW
NFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSE
TMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
212

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
24425

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
9.92

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  interaction between organisms
Process:  interspecies interaction between organisms
Process:  symbiosis, encompassing mutualism through parasitism
Process:  pathogenesis
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of organismal physiological process
Process:  regulation of vasoconstriction
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Endothelins are endothelium-derived vasoconstrictor peptides

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00322:Endothelin

# Macromolecular_Interacting_Partner_7_Signals:
1-17

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
31255

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
EDN1_HUMAN (P05305)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
EDN1

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
EDN1

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:3176

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>639 bp
ATGGATTATTTGCTCATGATTTTCTCTCTGCTGTTTGTGGCTTGCCAAGGAGCTCCAGAA
ACAGCAGTCTTAGGCGCTGAGCTCAGCGCGGTGGGTGAGAACGGCGGGGAGAAACCCACT
CCCAGTCCACCCTGGCGGCTCCGCCGGTCCAAGCGCTGCTCCTGCTCGTCCCTGATGGAT
AAAGAGTGTGTCTACTTCTGCCACCTGGACATCATTTGGGTCAACACTCCCGAGCACGTT
GTTCCGTATGGACTTGGAAGCCCTAGGTCCAAGAGAGCCTTGGAGAATTTACTTCCCACA
AAGGCAACAGACCGTGAGAATAGATGCCAATGTGCTAGCCAAAAAGACAAGAAGTGCTGG
AATTTTTGCCAAGCAGGAAAAGAACTCAGGGCTGAAGACATTATGGAGAAAGACTGGAAT
AATCATAAGAAAGGAAAAGACTGTTCCAAGCTTGGGAAAAAGTGTATTTATCAGCAGTTA
GTGAGAGGAAGAAAAATCAGAAGAAGTTCAGAGGAACACCTAAGACAAACCAGGTCGGAG
ACCATGAGAAACAGCGTCAAATCATCTTTTCATGATCCCAAGCTGAAAGGCAAGCCCTCC
AGAGAGCGTTATGTGACCCACAACCGAGCACATTGGTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
Y00749

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_7_Locus:
6p24.1

# Macromolecular_Interacting_Partner_7_SNPs:
Not Available

# Macromolecular_Interacting_Partner_7_General_References:
3282927; 2670930; 2659594; 8450044; 14574404; 2649896; 1864385; 9284755; 1515112; 7664037; 1859417; 1736987; 1422154; 7773179; 10231710; 10334806; 10391210

# Macromolecular_Interacting_Partner_7_References:
11430925; 11476758; 11566958; 12117304

# Macromolecular_Interacting_Partner_8_ID:
5766

# Macromolecular_Interacting_Partner_8_Name:
Kallikrein-1 precursor

# Macromolecular_Interacting_Partner_8_Synonyms:
Tissue kallikrein; Kidney/pancreas/salivary gland kallikrein

# Macromolecular_Interacting_Partner_8_Gene_Name:
KLK1

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Kallikrein1 precursor
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTQEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECEKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
262

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
28890

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
4.39

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Preferential cleavage of Arg-|- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|- or Leu-|-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-|- bonds [5]

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00089:Trypsin

# Macromolecular_Interacting_Partner_8_Signals:
1-18

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
EC 3.4.21.35

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
186653

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
KLK1_HUMAN (P06870)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
KLK1

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
KLK1

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:6357

# Macromolecular_Interacting_Partner_8_PDB_ID:
1SPJ

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>789 bp
ATGTGGTTCCTGGTTCTGTGCCTCGCCCTGTCCCTGGGGGGGACTGGTGCTGCGCCCCCG
ATTCAGTCCCGGATTGTGGGAGGCTGGGAGTGTGAGCAGCATTCCCAGCCCTGGCAGGCG
GCTCTGTACCATTTCAGCACTTTCCAGTGTGGGGGCATCCTGGTGCACCGCCAGTGGGTG
CTCACAGCTGCTCATTGCATCAGCGACAATTACCAGCTCTGGCTGGGTCGCCACAACTTG
TTTGACGACGAAAACACAGCCCAGTTTGTTCATGTCAGTGAGAGCTTCCCACACCCTGGC
TTCAACATGAGCCTCCTGGAGAACCACACCCGCCAAGCAGACGAGGACTACAGCCACGAC
CTCATGCTGCTCCGCCTGACAGAGCCTGCTGATACCATCACAGACGCTGTGAAGGTCGTG
GAGTTGCCCACCCAGGAACCCGAAGTGGGGAGCACCTGTTTGGCTTCCGGCTGGGGCAGC
ATCGAACCAGAGAATTTCTCATTTCCAGATGATCTCCAGTGTGTGGACCTCAAAATCCTG
CCTAATGATGAGTGCGAAAAAGCCCACGTCCAGAAGGTGACAGACTTCATGCTGTGTGTC
GGACACCTGGAAGGTGGCAAAGACACCTGTGTGGGTGATTCAGGGGGCCCGCTGATGTGT
GATGGTGTGCTCCAAGGTGTCACATCATGGGGCTACGTCCCTTGTGGCACCCCCAATAAG
CCTTCTGTCGCCGTCAGAGTGCTGTCTTATGTGAAGTGGATCGAGGACACCATAGCGGAG
AACTCCTGA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
M25629

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_8_Locus:
19q13.3

# Macromolecular_Interacting_Partner_8_SNPs:
rs5517; rs5515; rs5516; rs5518; rs3212857; rs1054713; rs2659058; rs2659103; rs3212820; rs3212819; rs3212836; rs3212828; rs3212817; rs3212833; rs3212835; rs3212837; rs2740502; rs3212834; rs3212830; rs3212829; rs3212825; rs3212821; rs2411330; rs2659104; rs3212827; rs2740505; rs3212832; rs3212856; rs3212826; rs3212822; rs3212831; rs2659101; rs2659099; rs3212849; rs3212845; rs3212850; rs2739454; rs2659100; rs2411334; rs5519; rs3212846; rs3212844; rs3212851; rs3212848; rs3212841; rs3212816; rs3212847; rs12052047; rs3212855; rs2739398; rs2659102; rs3212815; rs5514; rs17855377; rs34493997; rs2739397; rs3212818; rs2434452; rs3212824; rs2740504; rs34174355; rs34086786; rs3212823; rs35559244; rs2740503; rs35535011; rs10420205; rs3212839; rs34301743; rs34258064; rs36217621; rs34656187; rs4802746; rs35641597; rs34148425; rs35581737; rs35496131; rs10403329; rs10403407; rs10403612; rs10406287; rs10406403; rs10406640; rs10406695; rs10406721; rs10406908; rs10414120; rs10417605; rs10417831; rs10417989; rs10420039; rs11672844; rs11672950; rs11879167; rs11881755; rs12104176; rs12104311; rs12104424; rs16987576; rs171953; rs197589; rs2434451; rs2456584; rs2560934; rs2560935; rs2659056; rs2659097; rs266112; rs266114; rs266115; rs266116; rs266117; rs266850; rs266851; rs2739405; rs2739411; rs2739415; rs2739416; rs2739417; rs2739425; rs2739426; rs2739435; rs3212805; rs3212808; rs3212809; rs3212810; rs3212812; rs3212852; rs3212854; rs36062730; rs3745522; rs3745523; rs3909863; rs7246740; rs7247190; rs7252904; rs788887; rs788888; rs8100734; rs8100766; rs8100969; rs8101564; rs8104227

# Macromolecular_Interacting_Partner_8_General_References:
3004571; 2898948; 2686621; 3853975; 2666327; 3163150; 393608; 3635530

# Macromolecular_Interacting_Partner_8_References:
15886273; 1710605

# Macromolecular_Interacting_Partner_9_ID:
7620

# Macromolecular_Interacting_Partner_9_Name:
Natriuretic peptides B precursor [Contains: Gamma-brain natriuretic peptide; Brain natriuretic peptide 32

# Macromolecular_Interacting_Partner_9_Synonyms:
BNP-32]

# Macromolecular_Interacting_Partner_9_Gene_Name:
NPPB

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Natriuretic peptides B precursor Contains: Gammabrain natriuretic peptide; Brain natriuretic peptide 32
MDPQTAPSRALLLLLFLHLAFLGGRSHPLGSPGSASDLETSGLQEQRNHLQGKLSELQVE
QTSLEPLQESPRPTGVWKSREVATEGIRGHRKMVLYTLRAPRSPKMVQGSGCFGRKMDRI
SSSSGLGCKVLRRH

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
134

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
14726

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
11.01

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. Helps restore the body's salt and water balance. Improves heart function

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00212:ANP

# Macromolecular_Interacting_Partner_9_Signals:
1-26

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
179515

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
ANFB_HUMAN (P16860)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
NPPB

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
NPPB

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:7940

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>405 bp
ATGGATCCCCAGACAGCACCTTCCCGGGCGCTCCTGCTCCTGCTCTTCTTGCATCTGGCT
TTCCTGGGAGGTCGTTCCCACCCGCTGGGCAGCCCCGGTTCAGCCTCGGACTTGGAAACG
TCCGGGTTACAGGAGCAGCGCAACCATTTGCAGGGCAAACTGTCGGAGCTGCAGGTGGAG
CAGACATCCCTGGAGCCCCTCCAGGAGAGCCCCCGTCCCACAGGTGTCTGGAAGTCCCGG
GAGGTAGCCACCGAGGGCATCCGTGGGCACCGCAAAATGGTCCTCTACACCCTGCGGGCA
CCACGAAGCCCCAAGATGGTGCAAGGGTCTGGCTGCTTTGGGAGGAAGATGGACCGGATC
AGCTCCTCCAGTGGCCTGGGCTGCAAAGTGCTGAGGCGGCATTAA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
M31776

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_9_Locus:
1p36.2

# Macromolecular_Interacting_Partner_9_SNPs:
rs5227; rs5229; rs35628673; rs5228; rs198389; rs198381; rs198388; rs6541007; rs3753581; rs198386; rs549596; rs198387; rs35640285; rs5230; rs35690395; rs13305989; rs35519114; rs35207557; rs35458601; rs3831247; rs34331786; rs13305990; rs616308; rs198380; rs12124640; rs13305991; rs35533748; rs12047640; rs12121986; rs12118667; rs35587340; rs1003632; rs1009591; rs1009592; rs1076626; rs11801879; rs11802855; rs11803049; rs12029160; rs12091159; rs12402363; rs12406089; rs12406383; rs12562819; rs12562952; rs12753716; rs1318408; rs13305986; rs17376426; rs1800773; rs198372; rs198373; rs198375; rs4846061; rs5063; rs5064; rs632793; rs6668352; rs6668659; rs6676300; rs6694164; rs6695740

# Macromolecular_Interacting_Partner_9_General_References:
2597152; 2522777; 2138890; 2136732

# Macromolecular_Interacting_Partner_9_References:
1531333; 2148083; 8849584

# Macromolecular_Interacting_Partner_10_ID:
7007

# Macromolecular_Interacting_Partner_10_Name:
Phosphatidylinositol 3-kinase regulatory subunit alpha

# Macromolecular_Interacting_Partner_10_Synonyms:
PI3-kinase p85-subunit alpha; PtdIns-3-kinase p85-alpha; PI3K

# Macromolecular_Interacting_Partner_10_Gene_Name:
PIK3R1

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Phosphatidylinositol 3kinase regulatory subunit alpha
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH
VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
724

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
83599

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
6.06

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  lipid kinase activity
Function:  phosphoinositide 3-kinase activity
Function:  phosphatidylinositol 3-kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  guanyl nucleotide binding
Function:  GTP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  GTPase activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  protein complex
Component:  phosphoinositide 3-kinase complex

# Macromolecular_Interacting_Partner_10_General_Function:
Replication, recombination and repair 

# Macromolecular_Interacting_Partner_10_Specific_Function:
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00620:RhoGAP;
PF00017:SH2;
PF00018:SH3_1

# Macromolecular_Interacting_Partner_10_Signals:
None

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
P85A_HUMAN (P27986)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
PIK3R1

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
PIK3R1

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:8979

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
M61906

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_10_Locus:
5q13.1

# Macromolecular_Interacting_Partner_10_SNPs:
rs3730089; rs706713; rs3730090; rs3729981; rs7722222; rs3756668; rs2888323; rs3729984; rs12755; rs7702655; rs1131951; rs1043526; rs1643544; rs4016109; rs831125; rs171649; rs706714; rs251408; rs34303; rs2112208; rs895304; rs251409; rs251404; rs251399; rs1010793; rs10063119; rs2302976; rs2302975; rs6893676; rs3730082; rs34309; rs6861401; rs7733084; rs1664577; rs34301; rs10065413; rs831229; rs6876003; rs2302974; rs4122269; rs831123; rs10940160; rs10515070; rs173702; rs831122; rs6881033; rs7714169; rs3730086; rs17317833; rs3730087; rs10515074; rs6860081; rs16897511; rs3730088; rs12657050; rs7713645; rs7709243; rs6890202; rs42849; rs251402; rs6863431; rs34308; rs3815701; rs706716; rs40318; rs831121; rs3730078; rs10072475; rs1862162; rs6890176; rs12652661; rs34306; rs10515073; rs1445760; rs863818; rs1974781; rs1823023; rs17318918; rs173703; rs12659907; rs13156223; rs2161120; rs10940159; rs16897561; rs16897601; rs1819987; rs12697060; rs7716675; rs34304; rs4976156; rs16897558; rs11746842; rs12656176; rs251406; rs972634; rs1550805; rs7725370; rs173704; rs17839411; rs6863799; rs3730092; rs3730084; rs1862161; rs251410; rs6449960; rs7707370; rs994221; rs862714; rs11957103; rs2121109; rs2431166; rs10940158; rs7709991; rs6894871; rs831124; rs8192680; rs16897570; rs10940161; rs3730073; rs251405; rs16897562; rs28365970; rs6868872; rs251401; rs16897509; rs8192679; rs1946207; rs13173003; rs2431167; rs3730077; rs34300; rs34307; rs7713756; rs2121108; rs13167294; rs16897620; rs251407; rs1946208; rs3730091; rs17852841; rs34175949; rs17847317; rs10583550; rs1664558; rs41268435; rs9687541; rs17253369; rs2545411; rs7708232; rs10669997; rs1043425; rs10070142; rs34570857; rs5868531; rs7707793; rs3729983; rs35243561; rs34491401; rs7712540; rs10612198; rs10612201; rs7712126; rs5868532; rs7712114; rs34870423; rs35033772; rs33943986; rs10612200; rs2591417; rs2544847; rs1043426; rs1664560; rs34873643; rs1643545; rs9687422; rs36055833; rs9687539; rs1103100; rs1643543; rs34422073; rs3729982; rs35767695; rs34248986; rs13188418; rs251400; rs35255745; rs11285010; rs34010696; rs35510423; rs7717745; rs10577524; rs10614002; rs2591418; rs13154156; rs1611062; rs35472540; rs34305; rs6872284; rs1643556; rs11335573; rs1055643; rs9918196; rs10580592; rs861245; rs35373278; rs185179; rs34302; rs1643933; rs1643917; rs35582171; rs33965010; rs34287; rs36212686; rs11313149; rs185180; rs5868527; rs10552908; rs35213868; rs11343765; rs10579213; rs35812956; rs3049952; rs34037377; rs34027260; rs11351105; rs36121518; rs34476787; rs34330183; rs2545410; rs35893424; rs11291585; rs1819986; rs35728943; rs16897559; rs13180447; rs7732540; rs13153101; rs35800397; rs1300127; rs11349259; rs11334943; rs6872004; rs35918993; rs11308179; rs6871851; rs6872296; rs7735204; rs34157100; rs10461539; rs2591419; rs34695203; rs10036950; rs11960604; rs10611201; rs12153457; rs35508629; rs36029081; rs10055629; rs3730085; rs1643916; rs34594637; rs35918259; rs251403; rs11451948; rs35705146; rs10552907; rs10698662; rs5868528; rs7735075; rs1055644; rs34893631; rs34174926; rs34793287; rs34058255; rs5868529; rs4317277; rs11351869; rs34044740; rs11360241; rs10571324; rs862716; rs11280364; rs3730079; rs10678795; rs35929649; rs5024999; rs33968242; rs5868530; rs34063898; rs13163961; rs40056; rs35286739; rs35946831; rs34282574; rs36123886; rs13170618; rs34824771; rs34833428; rs6872690; rs10940157; rs11749932; rs11750202; rs40419; rs411751; rs450006; rs6449959; rs6872765; rs6899219; rs695166; rs706710; rs706711; rs706712; rs7701498; rs7701952; rs7723804; rs7732637; rs831227; rs9291926; rs9291927

# Macromolecular_Interacting_Partner_10_General_References:
1849461; 8628286; 7541045; 9489702; 9687533; 12359715; 12009866; 8648629; 8599763; 8962058; 11567151; 7681364; 8961927; 8670861; 9032108; 10768093

# Macromolecular_Interacting_Partner_10_References:
12629035

# Macromolecular_Interacting_Partner_11_ID:
6263

# Macromolecular_Interacting_Partner_11_Name:
Prostaglandin G/H synthase 2 precursor

# Macromolecular_Interacting_Partner_11_Synonyms:
Cyclooxygenase- 2; COX-2; Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; PHS II

# Macromolecular_Interacting_Partner_11_Gene_Name:
PTGS2

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Prostaglandin G/H synthase 2 precursor
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPT
PNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNAD
YGYKSWEAFSNLSYYTRALPP
VPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQ
GSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGL
GHGVDLNHIYGETLARQRKLRLFKDGK
MKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGL
VPGLMMYATIWLREHN
RVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPE
LLFNK
QFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQ
IAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMS
AELEALYGDIDAVELY
PALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKP
STFGGEVGFQIINTASIQSLICNNVKG
CPFTSFSVPDPELIKTVTINASSSRSGLDDIN
PTVLLKERSTEL

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
604

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
68997

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
7.41

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_11_General_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Specific_Function:
May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity

# Macromolecular_Interacting_Partner_11_Pathway:
map00590  Prostaglandin and leukotriene metabolism

# Macromolecular_Interacting_Partner_11_Reaction:
arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF03098:An_peroxidase;
PF00008:EGF

# Macromolecular_Interacting_Partner_11_Signals:
1-17

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
EC 1.14.99.1

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
291988

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
PGH2_HUMAN (P35354)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
PTGS2

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
PTGS2

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:9605

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Microsome; microsomal membrane; peripheral membrane protein

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>1815 bp

ATGCTCGCCCGCGCCCTGCTGCTGTGCGCGGTCCTGGCGCTCAGCCATACAGCAAATCC
TTGCTGTTCCC
ACCCATGTCAAAACCGAGGTGTATGTATGAGTGTGGGATTTGACCAGT
ATAAGTGCGATTGTACCCGGAC
AGGATTCTATGGAGAAAACTGCTCAACACCGGAATTT
TTGACAAGAATAAAATTATTTCTGAAACCCACT
CCAAACACAGTGCACTACATACTTAC
CCACTTCAAGGGATTTTGGAACGTTGTGAATAACATTCCCTTCC
TTCGAAATGCAATTA
TGAGTTATGTGTTGACATCCAGATCACATTTGATTGACAGTCCACCAACTTACAA
TGCT
GACTATGGCTACAAAAGCTGGGAAGCCTTCTCTAACCTCTCCTATTATACTAGAGCCCTT
CCTCCT
GTGCCTGATGATTGCCCGACTCCCTTGGGTGTCAAAGGTAAAAAGCAGCTTCC
TGATTCAAATGAGATTG
TGGAAAAATTGCTTCTAAGAAGAAAGTTCATCCCTGATCCCC
AGGGCTCAAACATGATGTTTGCATTCTT
TGCCCAGCACTTCACGCATCAGTTTTTCAAG
ACAGATCATAAGCGAGGGCCAGCTTTCACCAACGGGCTG
GGCCATGGGGTGGACTTAAA
TCATATTTACGGTGAAACTCTGGCTAGACAGCGTAAACTGCGCCTTTTCA
AGGATGGAA
AAATGAAATATCAGATAATTGATGGAGAGATGTATCCTCCCACAGTCAAAGATACTCAGG
C
AGAGATGATCTACCCTCCTCAAGTCCCTGAGCATCTACGGTTTGCTGTGGGGCAGGAG
GTCTTTGGTCTG
GTGCCTGGTCTGATGATGTATGCCACAATCTGGCTGCGGGAACACAA
CAGAGTATGCGATGTGCTTAAAC
AGGAGCATCCTGAATGGGGTGATGAGCAGTTGTTCC
AGACAAGCAGGCTAATACTGATAGGAGAGACTAT
TAAGATTGTGATTGAAGATTATGTG
CAACACTTGAGTGGCTATCACTTCAAACTGAAATTTGACCCAGAA
CTACTTTTCAACAA
ACAATTCCAGTACCAAAATCGTATTGCTGCTGAATTTAACACCCTCTATCACTGGC
ATC
CCCTTCTGCCTGACACCTTTCAAATTCATGACCAGAAATACAACTATCAACAGTTTATCT
ACAACAA
CTCTATATTGCTGGAACATGGAATTACCCAGTTTGTTGAATCATTCACCAGG
CAAATTGCTGGCAGGGTT
GCTGGTGGTAGGAATGTTCCACCCGCAGTACAGAAAGTATC
ACAGGCTTCCACTGACCAGAGCAGGCAGA
TGAAATACCAGTCTTTTAATGAGTACCGCA
AACGCTTTATGCTGAAGCCCTATGAATCATTTGAAGAACT
TACAGGAGAAAAGGAAATG
TCTGCAGAGTTGGAAGCACTCTATGGTGACATCGATGCTGTGGAGCTGTAT
CCTGCCCT
TCTGGTAGAAAAGCCTCGGCCAGATGCCATCTTTGGTGAAACCATGGTAGAAGTTGGAGC
AC
CATTCTCCTTGAAAGGACTTATGGGTAATGTTATATGTTCTCCTGCCTACTGGAAGC
CAAGCACTTTTGG
TGGAGAAGTGGGTTTTCAAATCATCAACACTGCCTCAATTCAGTCT
CTCATCTGCAATAACGTGAAGGGC
TGTCCCTTTACTTCATTCAGTGTTCCAGATCCAGA
GCTCATTAAAACAGTCACCATCAATGCAAGTTCTT
CCCGCTCCGGACTAGATGATATCA
ATCCCACAGTACTACTAAAAGAACGTTCGACTGAACTGTAG

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
L15326

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_11_Locus:
1q25.2-q25.3

# Macromolecular_Interacting_Partner_11_SNPs:
rs3218622; rs5272; rs5273; rs3218625; rs5279; rs5277; rs5278; rs5274; rs3218623; rs20429; rs4648265; rs5276; rs5275; rs2206593; rs4648292; rs689469; rs5271; rs3835508; rs689467; rs689470; rs689468; rs4648257; rs4648303; rs1051897; rs4648300; rs4648290; rs1051896; rs4648297; rs4648302; rs4648296; rs20432; rs2066826; rs4648268; rs4648287; rs20427; rs4648283; rs4648274; rs4648273; rs4648278; rs20430; rs4648284; rs20428; rs4648272; rs11567821; rs4648276; rs4648282; rs4648261; rs2745557; rs2066824; rs4648285; rs4648267; rs2066823; rs4648263; rs16825748; rs3218626; rs4648277; rs11567827; rs11567834; rs4648280; rs20434; rs2066822; rs4648271; rs4648262; rs4648258; rs16825745; rs20433; rs20424; rs4648306; rs20419; rs4648307; rs20415; rs4648308; rs689466; rs689465; rs20418; rs5270; rs4648251; rs4648256; rs4648304; rs4648310; rs20417; rs4648250; rs3918304; rs4648311; rs689462; rs20423; rs20420; rs2734779; rs11567815; rs11567831; rs11567814; rs4648309; rs20416; rs4648305; rs4648254; rs20426; rs4648279; rs4648264; rs4648288; rs3218624; rs3179567; rs4648295; rs36233646; rs3134592; rs3134591; rs4648299; rs4648298; rs13306032; rs11384450; rs11567830; rs13306038; rs3134589; rs13306033; rs2853804; rs3134590; rs2853805; rs11567829; rs11567819; rs4648289; rs4648301; rs13306035; rs34888870; rs4648294; rs13306031; rs4648293; rs2853803; rs4987012; rs12759220; rs11567822; rs4648260; rs4648269; rs11567826; rs13306034; rs4648259; rs11567820; rs4648266; rs11567825; rs4648281; rs11567824; rs11567823; rs4648286; rs4648270; rs4322189; rs35440347; rs11567835; rs689463; rs4648253; rs2223626; rs11567832; rs689464; rs20421; rs4648252; rs2745558; rs34901173; rs4648255; rs11567833; rs20422; rs11567837; rs11567836; rs12027712; rs10649972; rs10911902; rs10911905; rs10911907; rs10911908; rs1119064; rs1119065; rs11583191; rs12042763; rs12064238; rs12124257; rs12749248; rs2143416; rs2143417; rs2179555; rs2383515; rs2734776; rs2734777; rs2745559; rs4422959; rs6684912

# Macromolecular_Interacting_Partner_11_General_References:
8473346; 1380156; 8181472; 7945196

# Macromolecular_Interacting_Partner_11_References:
12167602; 14637180; 15834289

# Macromolecular_Interacting_Partner_12_ID:
5977

# Macromolecular_Interacting_Partner_12_Name:
Adenylate cyclase type 7

# Macromolecular_Interacting_Partner_12_Synonyms:
Adenylate cyclase type VII; ATP pyrophosphate-lyase 7; Adenylyl cyclase 7

# Macromolecular_Interacting_Partner_12_Gene_Name:
ADCY7

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Adenylate cyclase type 7
MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPS
RHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAA
CAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQL
LANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAH
ISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKEL
VVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQ
VREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT
LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRA
SVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRS
EDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACA
SLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISER
VETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLP
YYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKP
NGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFET
MENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKE
GLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAH
IGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVAS
RMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN


# Macromolecular_Interacting_Partner_12_Number_of_Residues:
1080

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
120310

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
8.16

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  cyclase activity
Function:  adenylate cyclase activity
Function:  catalytic activity
Function:  lyase activity
Function:  phosphorus-oxygen lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  cyclic nucleotide biosynthesis
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_12_General_Function:
Signal transduction mechanisms 

# Macromolecular_Interacting_Partner_12_Specific_Function:
This is a membrane-bound, calcium-inhibitable adenylyl cyclase

# Macromolecular_Interacting_Partner_12_Pathway:
map00230  Purine metabolism

# Macromolecular_Interacting_Partner_12_Reaction:
ATP = 3',5'-cyclic AMP + diphosphate

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF06327:DUF1053;
PF00211:Guanylate_cyc

# Macromolecular_Interacting_Partner_12_Signals:
None

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
34-54
63-83
95-117
122-142
147-167
176-196
595-615
620-640
669-688
718-737
746-773
794-814

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
EC 4.6.1.1

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
40788941

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
ADCY7_HUMAN (P51828)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
ADCY7

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
ADCY7

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:238

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>3267 bp
CGACACGCGTGCCAAGGGTGGAGGATGCCAGCCAAGGGGCGCTACTTCCTCAACGAGGGC
GAGGAGGGCCCTGACCAAGATGCGCTCTACGAGAAGTACCAGCTCACCAGCCAGCATGGG
CCGCTGCTGCTCACGCTCCTGCTGGTGGCCGCCACTGCCTGCGTGGCCCTCATCATCATT
GCCTTCAGCCAGGGGGACCCCTCCAGACACCAGGCCATTCTGGGCATGGCGTTCCTGGTG
CTGGCGGTGTTTGCGGCCCTCTCTGTGCTGATGTACGTCGAGTGTCTCCTGCGGCGCTGG
CTCAGGGCCTTGGCGCTGCTCACCTGGGCCTGCTTGGTGGCGCTGGGCTATGTGCTGGTG
TTCGACGCATGGACAAAGGCGGCCTGTGCGTGGGAGCAGGTGCCCTTCTTCCTGTTCATT
GTCTTCGTGGTGTACACACTACTGCCCTTCAGCATGCGGGGCGCTGTCGCCGTTGGGGCC
GTCTCCACTGCCTCCCACCTCCTGGTGCTCGGTTCTTTGATGGGAGGCTTCACGACACCC
AGTGTCCGGGTGGGGCTGCAGCTGCTGGCCAACGCAGTCATCTTCCTGTGTGGGAACCTG
ACAGGCGCCTTCCACAAGCACCAAATGCAGGATGCGTCCCGGGACCTCTTCACCTACACT
GTGAAGTGCATCCAGATCCGCCGGAAGCTGCGCATCGAGAAGCGCCAGCAGGAGAACCTG
CTGCTGTCAGTGCTTCCGGCCCACATCTCCATGGGCATGAAGCTGGCCATCATCGAACGG
CTCAAGGAGCATGGTGACCGTCGCTGCATGCCTGACAACAACTTCCACAGCCTCTACGTC
AAGAGGCACCAGAATGTCAGCATCCTCTATGCGGACATCGTGGGCTTCACGCAGCTGGCC
AGCGACTGTTCTCCCAAGGAGCTGGTGGTGGTGCTGAATGAGCTCTTTGGCAAGTTCGAC
CAGATCGCCAAGGCCAACGAGTGCATGCGAATCAAGATCCTCGGCGACTGCTACTACTGT
GTATCGGGCCTGCCCGTGTCGCTGCCTACCCACGCCCGGAACTGCGTGAAGATGGGGCTG
GACATGTGCCAGGCCATCAAGCAGGTGCGGGAGGCCACGGGCGTGGACATCAACATGCGT
GTGGGCATACACTCGGGGAATGTGCTGTGCGGGGTCATCGGGCTGCGCAAGTGGCAGTAT
GACGTGTGGTCCCACGACGTGTCCCTGGCCAACCGGATGGAGGCAGCCGGAGTACCCGGC
CGGGTGCACATCACGGAGGCCACGCTAAAGCACCTGGACAAGGCGTACGAGGTGGAGGAT
GGGCACGGGCAGCAGCGGGACCCCTACCTCAAGGAGATGAACATCCGCACCTACCTGGTC
ATCGACCCCCGGAGCCAGCAGCCACCCCCGCCCAGCCAACACCTCCCCAGGCCCAAGGGG
GACGCGGCCCTGAAGATGCGGGCGTCAGTGCGCATGACCCGGTACCTCGAGTCCTGGGGG
GCGGCACGGCCCTTTGCACATCTCAACCACCGTGAGAGCGTGAGCAGTGGTGAGACCCAC
GTCCCCAACGGGCGGAGGCCTAAGAGCGTTCCCCAGCGCCACCGCCGGACCCCAGACAGA
AGCATGTCCCCCAAGGGGCGGTCGGAGGATGACTCGTACGATGACGAGATGCTGTCAGCC
ATTGAGGGGCTCAGCTCCACGAGGCCCTGCTGCTCCAAGTCCGATGACTTCTACACCTTT
GGGTCCATCTTCCTGGAGAAGGGCTTTGAGCGCGAGTACCGCCTGGCACCCATCCCCCGG
GCCCGCCACGACTTTGCCTGCGCCAGCCTGATCTTCGTCTGCATCCTGCTCGTCCATGTC
CTGCTCATGCCCAGGACGGCGGCACTGGGTGTGTCCTTCGGGCTGGTGGCCTGTGTACTG
GGGCTGGTGCTGGGCCTGTGCTTTGCCACCAAGTTCTCGAGGTGCTGCCCAGCTCGGGGG
ACGCTCTGCACTATCTCTGAGAGGGTGGAGACACAGCCCCTGCTGAGGCTGACCCTGGCC
GTCCTGACCATCGGCAGCCTGCTCACTGTGGCCATCATCAACCTGCCCCTGATGCCTTTC
CAAGTTCCAGAGCTGCCTGTTGGCAATGAGACAGGCCTACTGGCCGCGAGCAGCAAGACA
AGAGCCCTGTGTGAGCCCCTCCCGTACTACACCTGCAGCTGTGTCCTGGGCTTCATCGCC
TGCTCGGTCTTCCTGAGGATGAGCCTGGAGCCAAAGGTTGTGCTGCTGACAGTGGCCCTG
GTGGCCTACCTGGTGCTCTTCAACCTCTCCCCATGCTGGCAGTGGGACTGCTGCGGCCAA
GGCCTGGGCAACCTCACCAAGCCCAACGGCACCACCAGTGGCACCCCTAGCTGTTCCTGG
AAGGACCTGAAGACCATGACCAATTTCTACCTGGTCCTGTTCTACATCACCCTGCTTACA
CTCTCCAGACAGATTGACTATTACTGCCGCTTGGACTGCCTATGGAAGAAGAAGTTCAAG
AAGGAGCACGAGGAGTTTGAGACCATGGAGAACGTGAACCGCCTTCTTCTGGAGAACGTC
CTGCCAGCCCACGTGGCTGCCCACTTTATCGGTGACAAGTTAAACGAGGACTGGTACCAT
CAGTCCTATGACTGCGTCTGTGTCATGTTTGCCTCCGTGCCGGACTTCAAAGTGTTCTAC
ACAGAGTGCGATGTCAACAAAGAAGGGCTGGAGTGCCTACGCCTGCTCAATGAGATCATT
GCCGACTTCGACGAGCTCCTACTGAAGCCCAAGTTCAGCGGCGTGGAGAAGATCAAGACC
ATCGGCAGCACGTACATGGCAGCTGCAGGGCTCAGCGTCGCCTCAGGGCACGAGAACCAG
GAGCTGGAGCGGCAGCATGCCCACATTGGTGTCATGGTGGAGTTCAGCATCGCCCTGATG
AGTAAGCTGGACGGCATCAACAGGCACTCCTTCAACTCCTTCCGCCTCCGCGTCGGCATA
AACCATGGGCCTGTGATTGCTGGAGTGATTGGGGCCCGAAAACCTCAGTATGACATCTGG
GGAAACACTGTCAATGTGGCCAGCCGAATGGAAAGCACTGGAGAACTTGGGAAAATCCAG
GTTACCGAGGAGACCTGCACCATCCTCCAGGGCCTCGGGTACTCTTGTGAATGCCGTGGC
CTGATCAACGTCAAAGGCAAAGGCGAGCTGAGGACTTACTTTGTCTGTACGGACACTGCC
AAGTTTCAGGGGCTGGGGCTGAACTGA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
D25538

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_12_Locus:
16q12-q13

# Macromolecular_Interacting_Partner_12_SNPs:
rs17289102; rs11861332; rs1064448; rs1872691; rs11644926; rs1540624; rs2302681; rs8052384; rs9939322; rs4785211; rs9936021; rs4785403; rs8061123; rs9926131; rs7191958; rs4785210; rs4785402; rs3813755; rs729229; rs2302712; rs11649380; rs9924714; rs8045659; rs8049122; rs2302680; rs7193839; rs11648839; rs7193875; rs2302717; rs2302715; rs12445243; rs11859417; rs728962; rs2302716; rs11861597; rs7202127; rs7186882; rs12444679; rs8056293; rs3833062; rs2302679; rs9927261; rs8060642; rs4082435; rs3826173; rs3892156; rs3760012; rs3760011; rs28514808; rs7359472; rs2230664; rs1064447; rs8051594; rs35787328; rs10589177; rs9940992; rs4785407; rs12918980; rs12444266; rs7500891; rs5816686; rs35969283; rs34860956; rs34493825; rs9937781; rs35262781; rs2302678; rs13332825; rs12932721; rs34996336; rs2302714; rs11640409; rs12932722; rs16948389; rs34039653; rs28510819; rs28432797; rs3841348; rs3214383; rs3815562; rs35078746; rs34191947; rs11403746; rs4502213; rs34381393; rs7197662; rs35284914; rs28403987; rs2302713; rs12919306; rs35003370; rs35732926; rs35829985; rs34216705; rs11352304; rs10577557; rs12444236; rs12924307; rs12598249; rs11417859; rs12443620; rs8048743; rs34009001; rs34686094; rs8053067; rs1078151; rs11644043; rs11645133; rs11649621; rs11860192; rs17216076; rs1872688; rs34176129; rs3760013; rs3760014; rs4497684; rs4785401; rs4785408; rs7184476; rs7184802; rs7196135; rs7204026; rs751127; rs8046783; rs8057103; rs8061808; rs9922362; rs9926720; rs9937029; rs9940619

# Macromolecular_Interacting_Partner_12_General_References:
7584026

# Macromolecular_Interacting_Partner_12_References:
9798534

# Macromolecular_Interacting_Partner_13_ID:
7120

# Macromolecular_Interacting_Partner_13_Name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit precursor

# Macromolecular_Interacting_Partner_13_Synonyms:
G gamma-I

# Macromolecular_Interacting_Partner_13_Gene_Name:
GNG2

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Guanine nucleotidebinding protein GI/GS/GO gamma2 subunit precursor
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
FREKKFFCAIL

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
71

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
7850

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
8.22

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
Function:  signal transducer activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  extrinsic to membrane
Component:  extrinsic to plasma membrane
Component:  heterotrimeric G-protein complex

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF00631:G-gamma

# Macromolecular_Interacting_Partner_13_Signals:
None

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
20147633

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
GBG2_HUMAN (P59768)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
GNG2

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
GNG2

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:4404

# Macromolecular_Interacting_Partner_13_PDB_ID:
1GP2

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Cell membrane; lipid-anchor; cytoplasmic side (Potential)

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>216 bp
ATGGCCAGCAACAACACCGCCAGCATAGCACAAGCCAGGAAGCTGGTAGAGCAGCTTAAG
ATGGAAGCCAATATCGACAGGATAAAGGTGTCCAAGGCAGCTGCAGATTTGATGGCCTAC
TGTGAAGCACATGCCAAGGAAGACCCCCTCCTGACCCCTGTTCCGGCTTCAGAAAACCCG
TTTAGGGAGAAGAAGTTTTTCTGTGCCATCCTTTAA

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
AF493870

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_13_Locus:
14q21

# Macromolecular_Interacting_Partner_13_SNPs:
rs2173147; rs1540703; rs1057804; rs1890698; rs1953861; rs1253671; rs1253705; rs10150753; rs4898723; rs8008081; rs4271524; rs8014746; rs8017436; rs2357306; rs1618825; rs8006278; rs1959517; rs4271525; rs1253685; rs8019194; rs1253687; rs1693198; rs1253707; rs3204006; rs6572805; rs1253669; rs8014732; rs7153584; rs12883315; rs6572803; rs4901174; rs1253696; rs12883290; rs7158342; rs8019331; rs11157869; rs12435475; rs10131301; rs12889199; rs4898725; rs1253690; rs7154422; rs6572804; rs8011452; rs1253703; rs12435509; rs2000006; rs4901173; rs6572802; rs1253691; rs11621156; rs11851703; rs7160163; rs7154419; rs11157865; rs11623465; rs1253708; rs1253672; rs10143072; rs8020243; rs10498440; rs8015777; rs11623590; rs1253692; rs11157864; rs11623924; rs7152919; rs11624752; rs17124753; rs11625611; rs1959518; rs2357302; rs12434038; rs12894908; rs12882906; rs1874566; rs8019382; rs3742539; rs11621160; rs8007155; rs10498438; rs1343870; rs10498439; rs8010684; rs1953859; rs1253686; rs12147761; rs1890699; rs10129965; rs11157866; rs2357249; rs4901171; rs1623101; rs11624779; rs8009095; rs12588848; rs1693203; rs1253698; rs4514593; rs10133203; rs1253704; rs3742541; rs2275459; rs8009132; rs11622145; rs1253706; rs10146408; rs7143686; rs2357247; rs1253699; rs7150643; rs8010820; rs10147806; rs17124732; rs1253689; rs1253700; rs2357304; rs1269967; rs9635225; rs17124751; rs1953858; rs7148779; rs35277565; rs12588519; rs11625461; rs8003709; rs8009835; rs10147177; rs4901175; rs1253693; rs11628249; rs8009405; rs10144829; rs1693199; rs12880965; rs2357305; rs8014838; rs8005440; rs7143789; rs12890422; rs12100449; rs3818870; rs1316298; rs7494751; rs1578974; rs17124744; rs11621108; rs3742540; rs7144109; rs1253702; rs17252733; rs17124725; rs17124746; rs3742537; rs1109745; rs12101277; rs1253701; rs11850819; rs8010780; rs10220546; rs17124713; rs12895034; rs17124709; rs7153274; rs3204008; rs11847330; rs1253632; rs1262155; rs17092983; rs3825596; rs7143009; rs1253656; rs1693204; rs1253636; rs1253634; rs4898728; rs1032583; rs1032582; rs1253657; rs7141670; rs3825604; rs10873055; rs8019374; rs7147405; rs1253660; rs4633613; rs1253655; rs1253645; rs3825603; rs3825597; rs12431532; rs1253646; rs1253633; rs3825602; rs2236561; rs1253642; rs1032584; rs1253643; rs1253648; rs1253658; rs1253644; rs17124780; rs12432144; rs1253647; rs12436573; rs1271518; rs1253664; rs12433722; rs1253652; rs17124772; rs3825600; rs17124796; rs4898727; rs1253639; rs1497089; rs12431528; rs11850096; rs1253662; rs1253665; rs12433696; rs1253640; rs12894196; rs1272117; rs1253649; rs11847688; rs1253638; rs17124774; rs1253641; rs3825601; rs1693177; rs1253635; rs2236562; rs17124768; rs11157867; rs1253653; rs8019625; rs1253654; rs7144097; rs1253663; rs11847372; rs7159454; rs11157868; rs1253650; rs17831501; rs1253666; rs1253651; rs17124698; rs9743514; rs950010; rs12889322; rs36047102; rs36067357; rs35614601; rs4523850; rs35174771; rs35178030; rs35139612; rs12889284; rs7148451; rs35822692; rs12886703; rs35819066; rs35462757; rs10539775; rs35213821; rs35673554; rs17831464; rs8011560; rs17124735; rs35190987; rs34192983; rs2884152; rs35975919; rs28694719; rs1497081; rs36016212; rs10717240; rs34445110; rs11354444; rs35455303; rs36032151; rs7158119; rs4898724; rs34308582; rs34283228; rs5808640; rs8011272; rs34329964; rs35145745; rs34857364; rs1693193; rs12890418; rs34693198; rs12586590; rs10689259; rs35336316; rs11322637; rs11322270; rs34146466; rs35195529; rs35803539; rs4347544; rs2067829; rs11428089; rs1953860; rs17252712; rs5808641; rs34973942; rs11315945; rs34499635; rs33911162; rs35429944; rs35289455; rs7161446; rs28718093; rs8013372; rs1253688; rs2357303; rs34764790; rs7156066; rs10543520; rs34028168; rs11623464; rs1253694; rs10150861; rs34653407; rs35238426; rs35433627; rs35848969; rs1959516; rs12586607; rs35870554; rs28459525; rs35495615; rs10083534; rs10539774; rs35583464; rs35727674; rs35105434; rs12882099; rs33955770; rs12895248; rs11463019; rs1272118; rs1253695; rs34361665; rs1253697; rs12894239; rs8005542; rs34031930; rs35437257; rs35846208; rs35134680; rs36078788; rs34449528; rs28410474; rs12896633; rs35857266; rs35561589; rs35748925; rs34420705; rs3030340; rs35420086; rs12589934; rs35009719; rs36010201; rs34591914; rs1959519; rs34670484; rs11288986; rs34986921; rs35088349; rs12894231; rs35622909; rs34263394; rs34779533; rs4456417; rs8010602; rs10624821; rs34877164; rs33974701; rs4901172; rs34780909; rs34248762; rs4309306; rs34782634; rs5808639; rs8004034; rs35616481; rs5808645; rs34701338; rs34410329; rs17124728; rs34480788; rs35453948; rs12889304; rs9707478; rs35484737; rs10604942; rs35494600; rs3832939; rs36123684; rs35923674; rs35156219; rs4898726; rs35052096; rs35374258; rs34240079; rs34350221; rs28688492; rs35192783; rs35005802; rs34991244; rs34006183; rs10134518; rs10140188; rs2357248; rs1253673; rs5808642; rs2047364; rs34966733; rs1620540; rs34110528; rs17124723; rs33933786; rs6145342; rs33922275; rs34470726; rs5808643; rs2790507; rs35561836; rs35675957; rs1769485; rs34653524; rs35548218; rs1693171; rs4589468; rs35319859; rs35289575; rs1269018; rs11326387; rs11301975; rs1769484; rs34265134; rs10646775; rs10636640; rs11301974; rs1253637; rs1693172; rs10684028; rs1693202; rs28437731; rs11847369; rs3825598; rs28613476; rs10643481; rs34424623; rs34270098; rs5808644; rs17252747; rs1253659; rs35702479; rs33913949; rs35088804; rs1253661; rs35348536; rs1769486; rs34736340; rs11847426; rs17831409; rs35153814; rs10529707; rs10137625; rs10138800; rs10145910; rs10146660; rs10150721; rs10151155; rs11844663; rs11844741; rs12433790; rs12436400; rs12436887; rs12587228; rs12589956; rs12878101; rs12878420; rs12886319; rs1693194; rs1693195; rs17124691; rs17124692; rs17124695; rs17124696; rs17124815; rs17252644; rs1769483; rs2357245; rs2357246; rs34468044; rs34867128; rs4901170; rs7154813

# Macromolecular_Interacting_Partner_13_General_References:
10833460

# Macromolecular_Interacting_Partner_13_References:
8613234; 9798534

# Macromolecular_Interacting_Partner_14_ID:
7803

# Macromolecular_Interacting_Partner_14_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_14_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_14_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_14_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_14_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_14_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_14_Pathway:
Not Available

# Macromolecular_Interacting_Partner_14_Reaction:
Not Available

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_14_Signals:
None

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_14_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_14_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_14_SNPs:
Not Available

# Macromolecular_Interacting_Partner_14_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_14_References:
8713080

# Macromolecular_Interacting_Partner_15_ID:
8206

# Macromolecular_Interacting_Partner_15_Name:
Nitric-oxide synthase, endothelial

# Macromolecular_Interacting_Partner_15_Synonyms:
EC-NOS; NOS type III; NOSIII; Endothelial NOS; eNOS; Constitutive NOS; cNOS

# Macromolecular_Interacting_Partner_15_Gene_Name:
NOS3

# Macromolecular_Interacting_Partner_15_Protein_Sequence:
>Nitricoxide synthase, endothelial
MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAPEHSPPSSPLT
QPPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAP
EQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRN
APRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGD
FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPP
ELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMST
EIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDH
HAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW
KGSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGR
LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSS
PRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHF
CAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAA
RDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATIRSVENLQSSKSTRATIL
VRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGP
PPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRRY
EEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVL
AYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAP
FRGFWQERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSRE
PDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDMELD
EAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPGSDT
NSP

# Macromolecular_Interacting_Partner_15_Number_of_Residues:
1203

# Macromolecular_Interacting_Partner_15_Molecular_Weight:
133290

# Macromolecular_Interacting_Partner_15_Theoretical_pI:
7.27

# Macromolecular_Interacting_Partner_15_GO_Classification:
>>>
Function:  monooxygenase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen
Function:  nitric-oxide synthase activity
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  biosynthesis
Process:  nitric oxide biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_15_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_15_Specific_Function:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets

# Macromolecular_Interacting_Partner_15_Pathway:
map00330  Arginine and proline metabolism

# Macromolecular_Interacting_Partner_15_Reaction:
L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+

# Macromolecular_Interacting_Partner_15_Pfam_Domain_Function:
PF00667:FAD_binding_1;
PF00258:Flavodoxin_1;
PF00175:NAD_binding_1;
PF02898:NO_synthase

# Macromolecular_Interacting_Partner_15_Signals:
None

# Macromolecular_Interacting_Partner_15_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_15_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_15_EC_Link:
EC 1.14.13.39

# Macromolecular_Interacting_Partner_15_GenBank_ID_Protein:
189212

# Macromolecular_Interacting_Partner_15_SwissProt_ID:
NOS3_HUMAN (P29474)

# Macromolecular_Interacting_Partner_15_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_15_Genecard_id:
NOS3

# Macromolecular_Interacting_Partner_15_Geneatlas_id:
NOS3

# Macromolecular_Interacting_Partner_15_hgnc_id:
HGNC:7876

# Macromolecular_Interacting_Partner_15_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_15_Subcellular_Location:
Cell membrane; caveola. Cytoplasm; cytoskeleton. Golgi apparatus. Note= Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity

# Macromolecular_Interacting_Partner_15_Gene_Sequence:
>3612 bp
ATGGGCAACTTGAAGAGCGTGGCCCAGGAGCCTGGGCCACCCTGCGGCCTGGGGCTGGGG
CTGGGCCTTGGGCTGTGCGGCAAGCAGGGCCCAGCCACCCCGGCCCCTGAGCCCAGCCGG
GCCCCAGCATCCCTACTCCCACCAGCGCCAGAACACAGCCCCCCGAGCTCCCCGCTAACC
CAGCCCCCAGAGGGGCCCAAGTTCCCTCGTGTGAAGAACTGGGAGGTGGGGAGCATCACC
TATGACACCCTCAGCGCCCAGGCGCAGCAGGATGGGCCCTGCACCCCAAGACGCTGCCTG
GGCTCCCTGGTATTTCCACGGAAACTACAGGGCCGGCCCTCCCCCGGCCCCCCGGCCCCT
GAGCAGCTGCTGAGTCAGGCCCGGGACTTCATCAACCAGTACTACAGCTCCATTAAGAGG
AGCGGCTCCCAGGCCCACGAACAGCGGCTTCAAGAGGTGGAAGCCGAGGTGGCAGCCACA
GGCACCTACCAGCTTAGGGAGAGCGAGCTGGTGTTCGGGGCTAAGCAGGCCTGGCGCAAC
GCTCCCCGCTGCGTGGGCCGGATCCAGTGGGGGAAGCTGCAGGTGTTCGATGCCCGGGAC
TGCAGGTCTGCACAGGAAATGTTCACCTACATCTGCAACCACATCAAGTATGCCACCAAC
CGGGGCAACCTTCGCTCGGCCATCACAGTGTTCCCGCAGCGCTGCCCTGGCCGAGGAGAC
TTCCGAATCTGGAACAGCCAGCTGGTGCGCTACGCGGGCTACCGGCAGCAGGACGGCTCT
GTGCGGGGGGACCCAGCCAACGTGGAGATCACCGAGCTCTGCATTCAGCACGGCTGGACC
CCAGGAAACGGTCGCTTCGACGTGCTGCCCCTGCTGCTGCAGGCCCCAGATGAGCCCCCA
GAACTCTTCCTTCTGCCCCCCGAGCTGGTCCTTGAGGTGCCCCTGGAGCACCCCACGCTG
GAGTGGTTTGCAGCCCTGGGCCTGCGCTGGTACGCCCTCCCGGCAGTGTCCAACATGCTG
CTGGAAATTGGGGGCCTGGAGTTCCCCGCAGCCCCCTTCAGTGGCTGGTACATGAGCACT
GAGATCGGCACGAGGAACCTGTGTGACCCTCACCGCTACAACATCCTGGAGGATGTGGCT
GTCTGCATGGACCTGGATACCCGGACCACCTCGTCCCTGTGGAAAGACAAGGCAGCAGTG
GAAATCAACGTGGCCGTGCTGCACAGTTACCAGCTAGCCAAAGTCACCATCGTGGACCAC
CACGCCGCCACGGCCTCTTTCATGAAGCACCTGGAGAATGAGCAGAAGGCCAGGGGGGGC
TGCCCTGCAGACTGGGCCTGGATCGTGCCCCCCATCTCGGGCAGCCTCACTCCTGTTTTC
CATCAGGAGATGGTCAACTATTTCCTGTCCCCGGCCTTCCGCTACCAGCCAGACCCCTGG
AAGGGGAGTGCCGCCAAGGGCACCGGCATCACCAGGAAGAAGACCTTTAAAGAAGTGGCC
AACGCCGTGAAGATCTCCGCCTCGCTCATGGGCACGGTGATGGCGAAGCGAGTGAAGGCG
ACAATCCTGTATGGCTCCGAGACCGGCCGGGCCCAGAGCTACGCACAGCAGCTGGGGAGA
CTCTTCCGGAAGGCTTTTGATCCCCGGGTCCTGTGTATGGATGAGTATGACGTGGTGTCC
CTCGAACACGAGACGCTGGTGCTGGTGGTAACCAGCACATTTGGGAATGGGGATCCCCCG
GAGAATGGAGAGAGCTTTGCAGCTGCCCTGATGGAGATGTCCGGCCCCTACAACAGCTCC
CCTCGGCCGGAACAGCACAAGAGTTATAAGATCCGCTTCAACAGCATCTCCTGCTCAGAC
CCACTGGTGTCCTCTTGGCGGCGGAAGAGGAAGGAGTCCAGTAACACAGACAGTGCAGGG
GCCCTGGGCACCCTCAGGTTCTGTGTGTTCGGGCTCGGCTCCCGGGCATACCCCCACTTC
TGCGCCTTTGCTCGTGCCGTGGACACACGGCTGGAGGAACTGGGCGGGGAGCGGCTGCTG
CAGCTGGGCCAGGGCGACGAGCTGTGCGGCCAGGAGGAGGCCTTCCGAGGCTGGGCCCAG
GCTGCCTTCCAGGCCGCCTGTGAGACCTTCTGTGTGGGAGAGGATGCCAAGGCCGCCGCC
CGAGACATCTTCAGCCCCAAACGGAGCTGGAAGCGCCAGAGGTACCGGCTGAGCGCCCAG
GCCGAGGGCCTGCAGTTGCTGCCAGGTCTGATCCACGTGCACAGGCGGAAGATGTTCCAG
GCTACAATCCGCTCAGTGGAAAACCTGCAAAGCAGCAAGTCCACGAGGGCCACCATCCTG
GTGCGCCTGGACACCGGAGGCCAGGAGGGGCTGCAGTACCAGCCGGGGGACCACATAGGT
GTCTGCCCGCCCAACCGGCCCGGCCTTGTGGAGGCGCTGCTGAGCCGCGTGGAGGACCCG
CCGGCGCCCACTGAGCCCGTGGCAGTAGAGCAGCTGGAGAAGGGCAGCCCTGGTGGCCCT
CCCCCCGGCTGGGTGCGGGACCCCCGGCTGCCCCCGTGCACGCTGCGCCAGGCTCTCACC
TTCTTCCTGGACATCACCTCCCCACCCAGCCCTCAGCTCTTGCGGCTGCTCAGCACCTTG
GCAGAAGAGCCCAGGGAACAGCAGGAGCTGGAGGCCCTCAGCCAGGATCCCCGACGCTAC
GAGGAGTGGAAGTGGTTCCGCTGCCCCACGCTGCTGGAGGTGCTGGAGCAGTTCCCGTCG
GTGGCGCTGCCTGCCCCACTGCTCCTCACCCAGCTGCCTCTGCTCCAGCCCCGGTACTAC
TCAGTCAGCTCGGCACCCAGCACCCACCCAGGAGAGATCCACCTCACTGTAGCTGTGCTG
GCATACAGGACTCAGGATGGGCTGGGCCCCCTGCACTATGGAGTCTGCTCCACGTGGCTA
AGCCAGCTCAAGCCCGGAGACCCTGTGCCCTGCTTCATCCGGGGGGCTCCCTCCTTCCGG
CTGCCACCCGATCCCAGCTTGCCCTGCATCCTGGTGGGTCCAGGCACTGGCATTGCCCCC
TTCCGGGGATTCTGGCAGGAGCGGCTGCATGACATTGAGAGCAAAGGGCTGCAGCCCACT
CCCATGACTTTGGTGTTCGGCTGCCGATGCTCCCAACTTGACCATCTCTACCGCGACGAG
GTGCAGAACGCCCAGCAGCGCGGGGTGTTTGGCCGAGTCCTCACCGCCTTCTCCCGGGAA
CCTGACAACCCCAAGACCTACGTGCAGGACATCCTGAGGACGGAGCTGGCTGCGGAGGTG
CACCGCGTGCTGTGCCTCGAGCGGGGCCACATGTTTGTCTGCGGCGATGTTACCATGGCA
ACCAACGTCCTGCAGACCGTGCAGCGCATCCTGGCGACGGAGGGCGACATGGAGCTGGAC
GAGGCCGGCGACGTCATCGGCGTGCTGCGGGATCAGCAACGCTACCACGAAGACATTTTC
GGGCTCACGCTGCGCACCCAGGAGGTGACAAGCCGCATACGCACCCAGAGCTTTTCCTTG
CAGGAGCGTCAGTTGCGGGGCGCAGTGCCCTGGGCGTTCGACCCTCCCGGCTCAGACACC
AACAGCCCCTGA

# Macromolecular_Interacting_Partner_15_GenBank_ID_Gene:
M93718

# Macromolecular_Interacting_Partner_15_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_15_Locus:
7q36

# Macromolecular_Interacting_Partner_15_SNPs:
rs3918234; rs3918232; rs1799983; rs3918201; rs3918166; rs2566514; rs9282804; rs34967063; rs3918233; rs35281220; rs1549758; rs9282803; rs3918163; rs1800779; rs3918226; rs3918159; rs3918160; rs2243311; rs3918162; rs2070744; rs3918225; rs1800783; rs3918155; rs3918158; rs3918157; rs3918156; rs3918161; rs1808593; rs743507; rs1008140; rs3793341; rs3918196; rs3730002; rs3730003; rs3918188; rs2566511; rs891511; rs3918177; rs3730305; rs3730009; rs867225; rs3918182; rs1007311; rs3834873; rs2853792; rs3918192; rs3918227; rs3918175; rs3918171; rs1800782; rs3918187; rs2853795; rs3918205; rs3918176; rs3918202; rs1541861; rs3918178; rs753482; rs3918204; rs3793342; rs3918174; rs3918167; rs3730010; rs1800781; rs3918203; rs1800780; rs3918198; rs3918180; rs3918194; rs3918184; rs891512; rs3729625; rs743506; rs3918181; rs3918190; rs3918228; rs3918172; rs3918230; rs3918169; rs3918191; rs3730001; rs2853796; rs3918186; rs3918170; rs3918165; rs3918183; rs34919745; rs3730006; rs34372288; rs35795287; rs3918193; rs34554797; rs3918179; rs3918164; rs13305982; rs3918197; rs3918229; rs2243310; rs3918231; rs3918189; rs3918173; rs3918168; rs3918195; rs3918199; rs3918185; rs3918200; rs11771443; rs41377046; rs6947833; rs7792133; rs41508746; rs11552661; rs2566519; rs34417010; rs2566516; rs35886277; rs11371169; rs35480369; rs33915751; rs3730306; rs2566513; rs11974098; rs2566508; rs13305984; rs2566512; rs13311166; rs13310774; rs3730007; rs7776461; rs2853798; rs13305985; rs2853791; rs34110189; rs35771718; rs41385244; rs2853800; rs2566515; rs34833695; rs41490944; rs1799984; rs13310854; rs10539416; rs2566509; rs2566506; rs28763995; rs6969597; rs41322052; rs2853797; rs2853794; rs2566510; rs10539415; rs10255980; rs28763996; rs41408449; rs13310763; rs2566507; rs41394247; rs10595051; rs4725985; rs34617549; rs3828997; rs2853793; rs34204527; rs10531586; rs10265237; rs10276930; rs10277237; rs1064353; rs1077872; rs12666088; rs12703107; rs13307588; rs2373929; rs2373961; rs2373962; rs2566518; rs3134740; rs3730011; rs3730012; rs3800787; rs3918207; rs3918211; rs3918212; rs3918215; rs3918218; rs3918220; rs4496877; rs6951150; rs933163

# Macromolecular_Interacting_Partner_15_General_References:
1378832; 1379542; 7688726; 7509596; 7519987; 7514568; 7475956; 10074942; 12437348; 9737779

# Macromolecular_Interacting_Partner_15_References:
11430925; 12600921; 12697739; 14993198

# Macromolecular_Interacting_Partner_16_ID:
8405

# Macromolecular_Interacting_Partner_16_Name:
Hypothetical protein

# Macromolecular_Interacting_Partner_16_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_16_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_16_Protein_Sequence:
>Hypothetical protein
MLFKAYMYLNEGQKLLKTLKKDKSWSQTFESATFYSLKGEVCFNMGQIVLAKKMLRKALK
LLNRIFPYNLISLFLHIHVEKNRHFHYVNRQAQESPPPGKKRLAQLYRQTVCLSLLWRIY
SYSYLFHCKYYAHLAVMMQMNTALETQNCFQIIKAYLDYSLYHHLAGYKGVWFKYEVMAM
EHIFNLPLKGEGIEIVAYVAETLVFNKLIMGHLDLAIELGSRALQMWALLQNPNRHYQSL
CRLSRCLLLNSRYPQLIQVLGRLWELSVTQEHIFSKAFFYFVCLDILLYSGFVYRTFEEC
LEFIHQYENNRILKFHSGLLLGLYSSVAIWECEAGVGRRLHTSRDPGMPDFRNGTTFTNF
PIELKIFCQEEP

# Macromolecular_Interacting_Partner_16_Number_of_Residues:
372

# Macromolecular_Interacting_Partner_16_Molecular_Weight:
43901

# Macromolecular_Interacting_Partner_16_Theoretical_pI:
9.26

# Macromolecular_Interacting_Partner_16_GO_Classification:
>>>
Function:  binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_16_General_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Pathway:
Not Available

# Macromolecular_Interacting_Partner_16_Reaction:
Not Available

# Macromolecular_Interacting_Partner_16_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Signals:
None

# Macromolecular_Interacting_Partner_16_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_16_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_16_EC_Link:
EC 4.6.1.1

# Macromolecular_Interacting_Partner_16_GenBank_ID_Protein:
4153951

# Macromolecular_Interacting_Partner_16_SwissProt_ID:
O95558_HUMAN (O95558)

# Macromolecular_Interacting_Partner_16_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_16_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_16_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_16_hgnc_id:
Not Available

# Macromolecular_Interacting_Partner_16_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_16_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_16_Gene_Sequence:
>1119 bp
ATGCTGTTCAAGGCATACATGTATTTGAATGAAGGACAGAAGTTGCTAAAAACTCTCAAG
AAGGACAAATCTTGGAGCCAGACATTTGAGTCTGCCACCTTTTACAGCCTCAAAGGTGAG
GTCTGTTTCAATATGGGCCAGATAGTGCTTGCCAAGAAAATGCTGAGGAAGGCACTGAAG
CTCCTCAACCGAATCTTTCCTTACAACTTAATCTCCTTGTTTCTCCATATCCATGTCGAG
AAAAACAGACACTTTCATTATGTGAATCGGCAGGCCCAAGAGAGCCCACCTCCAGGGAAG
AAGAGGCTGGCACAACTTTACCGGCAAACTGTCTGCCTTTCCTTGCTGTGGCGCATCTAT
AGCTACAGTTATCTTTTTCACTGCAAGTATTATGCCCACCTGGCAGTTATGATGCAAATG
AATACTGCACTGGAAACTCAAAATTGTTTCCAGATCATTAAGGCTTACCTAGACTATTCG
CTATACCACCACCTGGCTGGCTACAAAGGTGTGTGGTTCAAATATGAAGTCATGGCCATG
GAGCACATCTTCAACCTCCCCCTGAAAGGCGAGGGCATTGAAATCGTGGCATACGTGGCT
GAGACACTGGTCTTCAACAAGCTCATAATGGGACACCTGGATTTGGCCATTGAGTTAGGC
TCCCGAGCCCTTCAGATGTGGGCACTGCTCCAGAATCCCAACCGACATTATCAGTCCCTC
TGCAGACTTAGCAGATGTCTCCTTCTGAACAGCAGATACCCGCAATTGATCCAGGTGCTG
GGGCGGCTGTGGGAGCTTTCTGTAACACAGGAACACATCTTCAGCAAGGCATTTTTCTAT
TTTGTCTGCTTGGACATCCTGCTTTATTCTGGTTTTGTTTATAGAACATTTGAAGAATGT
TTGGAATTCATACACCAATACGAAAACAACAGAATCCTCAAGTTCCACAGTGGACTCCTC
CTGGGACTTTATTCCTCTGTAGCTATCTGGGAGTGTGAAGCAGGGGTAGGCAGGAGACTA
CACACTTCCAGAGACCCAGGTATGCCAGACTTCAGGAATGGGACAACTTTTACAAATTTT
CCAATAGAGCTAAAAATCTTTTGCCAAGAAGAACCATGA

# Macromolecular_Interacting_Partner_16_GenBank_ID_Gene:
AL035122

# Macromolecular_Interacting_Partner_16_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_16_Locus:
Not Available

# Macromolecular_Interacting_Partner_16_SNPs:
Not Available

# Macromolecular_Interacting_Partner_16_General_References:
Not Available

# Macromolecular_Interacting_Partner_16_References:
10779123; 1319958; 1398892

# Macromolecular_Interacting_Partner_17_ID:
8123

# Macromolecular_Interacting_Partner_17_Name:
Renin precursor

# Macromolecular_Interacting_Partner_17_Synonyms:
Angiotensinogenase

# Macromolecular_Interacting_Partner_17_Gene_Name:
REN

# Macromolecular_Interacting_Partner_17_Protein_Sequence:
>Renin precursor
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR

# Macromolecular_Interacting_Partner_17_Number_of_Residues:
406

# Macromolecular_Interacting_Partner_17_Molecular_Weight:
45058

# Macromolecular_Interacting_Partner_17_Theoretical_pI:
7.07

# Macromolecular_Interacting_Partner_17_GO_Classification:
>>>
Function:  pepsin A activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  aspartic-type endopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_17_General_Function:
Not Available

# Macromolecular_Interacting_Partner_17_Specific_Function:
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney

# Macromolecular_Interacting_Partner_17_Pathway:
Not Available

# Macromolecular_Interacting_Partner_17_Reaction:
Cleavage of Leu-|- bond in angiotensinogen to generate angiotensin I

# Macromolecular_Interacting_Partner_17_Pfam_Domain_Function:
PF07966:A1_Propeptide;
PF00026:Asp

# Macromolecular_Interacting_Partner_17_Signals:
1-23

# Macromolecular_Interacting_Partner_17_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_17_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_17_EC_Link:
EC 3.4.23.15

# Macromolecular_Interacting_Partner_17_GenBank_ID_Protein:
190994

# Macromolecular_Interacting_Partner_17_SwissProt_ID:
RENI_HUMAN (P00797)

# Macromolecular_Interacting_Partner_17_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_17_Genecard_id:
REN

# Macromolecular_Interacting_Partner_17_Geneatlas_id:
REN

# Macromolecular_Interacting_Partner_17_hgnc_id:
HGNC:9958

# Macromolecular_Interacting_Partner_17_PDB_ID:
1BBS

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_17_Subcellular_Location:
Secreted protein. Membrane. Note=Associated to membranes via binding to ATP6AP2

# Macromolecular_Interacting_Partner_17_Gene_Sequence:
>1221 bp
ATGGATGGATGGAGAAGGATGCCTCGCTGGGGACTGCTGCTGCTGCTCTGGGGCTCCTGT
ACCTTTGGTCTCCCGACAGACACCACCACCTTTAAACGGATCTTCCTCAAGAGAATGCCC
TCAATCCGAGAAAGCCTGAAGGAACGAGGTGTGGACATGGCCAGGCTTGGTCCCGAGTGG
AGCCAACCCATGAAGAGGCTGACACTTGGCAACACCACCTCCTCCGTGATCCTCACCAAC
TACATGGACACCCAGTACTATGGCGAGATTGGCATCGGCACCCCACCCCAGACCTTCAAA
GTCGTCTTTGACACTGGTTCGTCCAATGTTTGGGTGCCCTCCTCCAAGTGCAGCCGTCTC
TACACTGCCTGTGTGTATCACAAGCTCTTCGATGCTTCGGATTCCTCCAGCTACAAGCAC
AATGGAACAGAACTCACCCTCCGCTATTCAACAGGGACAGTCAGTGGCTTTCTCAGCCAG
GACATCATCACCGTGGGTGGAATCACGGTGACACAGATGTTTGGAGAGGTCACGGAGATG
CCCGCCTTACCCTTCATGCTGGCCGAGTTTGATGGGGTTGTGGGCATGGGCTTCATTGAA
CAGGCCATTGGCAGGGTCACCCCTATCTTCGACAACATCATCTCCCAAGGGGTGCTAAAA
GAGGACGTCTTCTCTTTCTACTACAACAGAGATTCCGAGAATTCCCAATCGCTGGGAGGA
CAGATTGTGCTGGGAGGCAGCGACCCCCAGCATTACGAAGGGAATTTCCACTATATCAAC
CTCATCAAGACTGGTGTCTGGCAGATTCAAATGAAGGGGGTGTCTGTGGGGTCATCCACC
TTGCTCTGTGAAGACGGCTGCCTGGCATTGGTAGACACCGGTGCATCCTACATCTCAGGT
TCTACCAGCTCCATAGAGAAGCTCATGGAGGCCTTGGGAGCCAAGAAGAGGCTGTTTGAT
TATGTCGTGAAGTGTAACGAGGGCCCTACACTCCCCGACATCTCTTTCCACCTGGGAGGC
AAAGAATACACGCTCACCAGCGCGGACTATGTATTTCAGGAATCCTACAGTAGTAAAAAG
CTGTGCACACTGGCCATCCACGCCATGGATATCCCGCCACCCACTGGACCCACCTGGGCC
CTGGGGGCCACCTTCATCCGAAAGTTCTACACAGAGTTTGATCGGCGTAACAACCGCATT
GGCTTCGCCTTGGCCCGCTGA

# Macromolecular_Interacting_Partner_17_GenBank_ID_Gene:
L00073

# Macromolecular_Interacting_Partner_17_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_17_Locus:
1q32

# Macromolecular_Interacting_Partner_17_SNPs:
rs11571117; rs11571098; rs11571083; rs5705; rs11571120; rs11571124; rs7521667; rs2887284; rs1464816; rs1917539; rs6693954; rs5706; rs11571123; rs10900555; rs6676670; rs10900557; rs11571079; rs11240688; rs11571108; rs10900556; rs2368564; rs11571104; rs11571102; rs5707; rs11571078; rs11571107; rs11571114; rs11571091; rs11571119; rs11571082; rs11571088; rs11571077; rs11571105; rs11240686; rs11571106; rs3215332; rs3795574; rs11571092; rs11571111; rs3795575; rs11571112; rs2177695; rs3730102; rs11240689; rs11571086; rs6665480; rs11571113; rs3730104; rs11571084; rs3730103; rs11571118; rs11571100; rs11240687; rs11571087; rs2272237; rs6674952; rs11571110; rs11571085; rs11571103; rs11571101; rs11571121; rs11240685; rs11571109; rs11571080; rs11571076; rs11578877; rs11571081; rs11571115; rs11571090; rs6676458; rs11571122; rs11571116; rs6681776; rs6668858; rs6682082; rs11571096; rs11571073; rs11571075; rs11571097; rs11571074; rs11571093; rs11571128; rs11571126; rs11571095; rs11571094; rs11571127; rs11571125; rs6704321; rs11542630; rs34069565; rs1126947; rs1042875; rs5704; rs1042874; rs11799601; rs3730101; rs28580264; rs13306600; rs11284490; rs28730746; rs13306601; rs28417178; rs4439406; rs34296392; rs3839003; rs35241727; rs5708; rs4396166; rs35201130; rs34481638; rs11571099; rs11581713; rs28730747; rs2177694; rs10494849; rs1106778; rs16853059; rs16853062; rs16853072; rs1917542; rs1997034; rs2293337; rs3795576; rs6688425; rs6702587; rs7539596; rs7548714; rs940651; rs940652

# Macromolecular_Interacting_Partner_17_General_References:
6324167; 3530608; 6391881; 6138751; 3032746; 2540188; 3516796; 2016271; 12045255; 2493678; 1608447

# Macromolecular_Interacting_Partner_17_References:
10576144; 11244026; 12600921; 14517226

# Macromolecular_Interacting_Partner_18_ID:
8108

# Macromolecular_Interacting_Partner_18_Name:
Angiotensinogen precursor

# Macromolecular_Interacting_Partner_18_Synonyms:
Serpin A8[Contains: Angiotensin-1; Angiotensin I; Ang I; Angiotensin-2; Angiotensin II; Ang II; Angiotensin-3; Angiotensin III; Ang III; Des-Asp[1]-angiotensin II]

# Macromolecular_Interacting_Partner_18_Gene_Name:
AGT

# Macromolecular_Interacting_Partner_18_Protein_Sequence:
>Angiotensinogen precursor
MRKRAPQSEMAPAGVSLRATILCLLAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAG
KPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGM
HSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKV
LSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLD
FTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEF
WVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLT
FQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIR
VGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVAN
PLSTA

# Macromolecular_Interacting_Partner_18_Number_of_Residues:
485

# Macromolecular_Interacting_Partner_18_Molecular_Weight:
53155

# Macromolecular_Interacting_Partner_18_Theoretical_pI:
6.27

# Macromolecular_Interacting_Partner_18_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  protease inhibitor activity
Function:  endopeptidase inhibitor activity
Function:  serine-type endopeptidase inhibitor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_18_General_Function:
Not Available

# Macromolecular_Interacting_Partner_18_Specific_Function:
Angiotensin-3 stimulates aldosterone release

# Macromolecular_Interacting_Partner_18_Pathway:
Not Available

# Macromolecular_Interacting_Partner_18_Reaction:
Not Available

# Macromolecular_Interacting_Partner_18_Pfam_Domain_Function:
PF00079:Serpin

# Macromolecular_Interacting_Partner_18_Signals:
1-33

# Macromolecular_Interacting_Partner_18_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_18_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_18_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_18_GenBank_ID_Protein:
178640

# Macromolecular_Interacting_Partner_18_SwissProt_ID:
ANGT_HUMAN (P01019)

# Macromolecular_Interacting_Partner_18_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_18_Genecard_id:
AGT

# Macromolecular_Interacting_Partner_18_Geneatlas_id:
AGT

# Macromolecular_Interacting_Partner_18_hgnc_id:
HGNC:333

# Macromolecular_Interacting_Partner_18_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_18_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_18_Gene_Sequence:
>1458 bp
ATGCGGAAGCGAGCACCCCAGTCTGAGATGGCTCCTGCCGGTGTGAGCCTGAGGGCCACC
ATCCTCTGCCTCCTGGCCTGGGCTGGCCTGGCTGCAGGTGACCGGGTGTACATACACCCC
TTCCACCTCGTCATCCACAATGAGAGTACCTGTGAGCAGCTGGCAAAGGCCAATGCCGGG
AAGCCCAAAGACCCCACCTTCATACCTGCTCCAATTCAGGCCAAGACATCCCCTGTGGAT
GAAAAGGCCCTACAGGACCAGCTGGTGCTAGTCGCTGCAAAACTTGACACCGAAGACAAG
TTGAGGGCCGCAATGGTCGGGATGCTGGCCAACTTCTTGGGCTTCCGTATATATGGCATG
CACAGTGAGCTATGGGGCGTGGTCCATGGGGCCACCGTCCTCTCCCCAACGGCTGTCTTT
GGCACCCTGGCCTCTCTCTATCTGGGAGCCTTGGACCACACAGCTGACAGGCTACAGGCA
ATCCTGGGTGTTCCTTGGAAGGACAAGAACTGCACCTCCCGGCTGGATGCGCACAAGGTC
CTGTCTGCCCTGCAGGCTGTACAGGGCCTGCTAGTGGCCCAGGGCAGGGCTGATAGCCAG
GCCCAGCTGCTGCTGTCCACGGTGGTGGGCGTGTTCACAGCCCCAGGCCTGCACCTGAAG
CAGCCGTTTGTGCAGGGCCTGGCTCTCTATACCCCTGTGGTCCTCCCACGCTCTCTGGAC
TTCACAGAACTGGATGTTGCTGCTGAGAAGATTGACAGGTTCATGCAGGCTGTGACAGGA
TGGAAGACTGGCTGCTCCCTGATGGGAGCCAGTGTGGACAGCACCCTGGCTTTCAACACC
TACGTCCACTTCCAAGGGAAGATGAAGGGCTTCTCCCTGCTGGCCGAGCCCCAGGAGTTC
TGGGTGGACAACAGCACCTCAGTGTCTGTTCCCATGCTCTCTGGCATGGGCACCTTCCAG
CACTGGAGTGACATCCAGGACAACTTCTCGGTGACTCAAGTGCCCTTCACTGAGAGCGCC
TGCCTGCTGCTGATCCAGCCTCACTATGCCTCTGACCTGGACAAGGTGGAGGGTCTCACT
TTCCAGCAAAACTCCCTCAACTGGATGAAGAAACTGTCTCCCCGGACCATCCACCTGACC
ATGCCCCAACTGGTGCTGCAAGGATCTTATGACCTGCAGGACCTGCTCGCCCAGGCTGAG
CTGCCCGCCATTCTGCACACCGAGCTGAACCTGCAAAAATTGAGCAATGACCGCATCAGG
GTGGGGGAGGTGCTGAACAGCATTTTTTTTGAGCTTGAAGCGGATGAGAGAGAGCCCACA
GAGTCTACCCAACAGCTTAACAAGCCTGAGGTCTTGGAGGTGACCCTGAACCGCCCATTC
CTGTTTGCTGTGTATGATCAAAGCGCCACTGCCCTGCACTTCCTGGGCCGCGTGGCCAAC
CCGCTGAGCACAGCATGA

# Macromolecular_Interacting_Partner_18_GenBank_ID_Gene:
K02215

# Macromolecular_Interacting_Partner_18_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_18_Locus:
1q42-q43

# Macromolecular_Interacting_Partner_18_SNPs:
rs11568032; rs699; rs11568053; rs34829218; rs4762; rs11568041; rs2478522; rs5040; rs11568052; rs2004776; rs3789679; rs7539020; rs3789678; rs11568028; rs11568050; rs2493134; rs3889728; rs11568051; rs1078499; rs11568025; rs11568022; rs7539013; rs2148582; rs11568024; rs3827750; rs11568023; rs11568026; rs11122576; rs5050; rs5044; rs11568021; rs11568027; rs11568049; rs11568029; rs11122578; rs11568030; rs5051; rs4753; rs11122577; rs11568031; rs5043; rs5042; rs913147; rs1326883; rs5052; rs7079; rs2478539; rs2493132; rs2493129; rs3789671; rs1926722; rs11568055; rs10864772; rs11568044; rs3789669; rs11568036; rs11568034; rs3789664; rs11568040; rs3789666; rs11568045; rs2478543; rs2478545; rs6687360; rs1926723; rs2493133; rs11568039; rs2478544; rs2493131; rs11122575; rs11568054; rs3827749; rs11568056; rs2493130; rs3789677; rs11568038; rs11568042; rs2478523; rs11568035; rs11568037; rs3789670; rs3789667; rs11568043; rs3789672; rs11568033; rs7543316; rs10864771; rs10864770; rs943580; rs11568048; rs11568014; rs5046; rs6683321; rs7536290; rs2071404; rs5049; rs2067853; rs11568057; rs11568019; rs11568016; rs11122580; rs11122574; rs11568015; rs943581; rs2071406; rs2071405; rs2493136; rs11568018; rs11122573; rs5045; rs11568046; rs5048; rs2478524; rs5047; rs2493135; rs16852352; rs11568017; rs11568020; rs7533803; rs5039; rs1805090; rs5041; rs11557882; rs13306155; rs11557881; rs1803105; rs2229389; rs11557883; rs41271499; rs17856352; rs11557884; rs11557886; rs11557885; rs4029126; rs1803106; rs1803104; rs34099195; rs15022; rs1800585; rs1045464; rs11684; rs35680836; rs1803103; rs35832019; rs28730748; rs34041147; rs34069211; rs35937843; rs12125552; rs13306154; rs3789665; rs35832452; rs34924695; rs34433365; rs36218431; rs10545629; rs10593363; rs34758442; rs5781599; rs11445360; rs34933000; rs36218766; rs1051038; rs10864769; rs10864773; rs12042687; rs12059975; rs12083907; rs12723373; rs12746025; rs1326885; rs1326886; rs1410142; rs1410144; rs1854053; rs2296801; rs2478534; rs2493125; rs2493127; rs2493137; rs3789657; rs3789662; rs4028824; rs4284270; rs4628514; rs4846866; rs7524283; rs7549009; rs7555650; rs9804147

# Macromolecular_Interacting_Partner_18_General_References:
6089875; 2924688; 1692023; 2885106; 3579322; 7259779; 7539791; 4300938; 3934016; 1132082; 9492317; 1394429; 8513325; 7607642; 7744780; 8621667

# Macromolecular_Interacting_Partner_18_References:
10437805; 12544443; 1614061; 1676939

# Macromolecular_Interacting_Partner_19_ID:
8444

# Macromolecular_Interacting_Partner_19_Name:
Transforming growth factor beta-1 precursor

# Macromolecular_Interacting_Partner_19_Synonyms:
TGF-beta-1[Contains: Latency-associated peptide; LAP]

# Macromolecular_Interacting_Partner_19_Gene_Name:
TGFB1

# Macromolecular_Interacting_Partner_19_Protein_Sequence:
>Transforming growth factor beta1 precursor
MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI
YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR
YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT
TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI
DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA
LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

# Macromolecular_Interacting_Partner_19_Number_of_Residues:
390

# Macromolecular_Interacting_Partner_19_Molecular_Weight:
44342

# Macromolecular_Interacting_Partner_19_Theoretical_pI:
8.63

# Macromolecular_Interacting_Partner_19_GO_Classification:
>>>
Function:  growth factor activity
Function:  signal transducer activity
Function:  receptor binding
Function:  transforming growth factor beta receptor binding
 ||
>>>
Process:  growth
Process:  cell growth
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_19_General_Function:
Not Available

# Macromolecular_Interacting_Partner_19_Specific_Function:
Multifunctional protein that control proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGFB1 and essentially all of them have specific receptors for this protein. It regulates the actions of many other growth factors and determines a positive or negative direction of their effects. It plays an important role in bone remodelling. It is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts

# Macromolecular_Interacting_Partner_19_Pathway:
Not Available

# Macromolecular_Interacting_Partner_19_Reaction:
Not Available

# Macromolecular_Interacting_Partner_19_Pfam_Domain_Function:
PF00019:TGF_beta;
PF00688:TGFb_propeptide

# Macromolecular_Interacting_Partner_19_Signals:
1-29

# Macromolecular_Interacting_Partner_19_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_19_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_19_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_19_GenBank_ID_Protein:
1212989

# Macromolecular_Interacting_Partner_19_SwissProt_ID:
TGFB1_HUMAN (P01137)

# Macromolecular_Interacting_Partner_19_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_19_Genecard_id:
TGFB1

# Macromolecular_Interacting_Partner_19_Geneatlas_id:
TGFB1

# Macromolecular_Interacting_Partner_19_hgnc_id:
HGNC:11766

# Macromolecular_Interacting_Partner_19_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_19_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_19_Gene_Sequence:
>355 bp
ATGCCGCCCTCCGGGCTGCGGCTGCTGCTGCTGCTGCTACCGCTGCTGTGGCTACTGGTG
CTGACGCCTGGCCGGCCGGCCGCGGGACTATCCACCTGCAAGACTATCGACATGGAGCTG
GTGAAGCGGAAGCGCATCGAGGCCATCCGCGGCCAGATCCTGTCCAAGCTGCGGCTCGCC
AGCCCCCCGAGCCAGGGGGAGGTGCCGCCCGGCCCGCTGCCCGAGGCCGTGCTCGCCCTG
TACAACAGCACCCGCGACCGGGTGGCCGGGGAGAGTGCAGAACCGGAGCCCGAGCCTGAG
GCCGACTACTACGCCAAGGAGGTCACCCGCGTGCTAATGGTGGAAACCCACAACG

# Macromolecular_Interacting_Partner_19_GenBank_ID_Gene:
X05839

# Macromolecular_Interacting_Partner_19_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_19_Locus:
19q13.2|19q13.1

# Macromolecular_Interacting_Partner_19_SNPs:
rs1982073; rs1800472; rs1800471; rs9282871; rs11466316; rs11466315; rs2241717; rs7408955; rs2278422; rs13306709; rs7258445; rs2288873; rs747857; rs8110090; rs11466329; rs2288874; rs11466347; rs2241716; rs8179181; rs8102501; rs11466345; rs8105161; rs6508976; rs4803455; rs1989457; rs11466338; rs10405403; rs8108052; rs2241715; rs11466335; rs11466357; rs12461895; rs6508975; rs11466337; rs11466351; rs11466344; rs12462166; rs11466331; rs11466341; rs11466324; rs11466359; rs11466318; rs10420084; rs11466356; rs11466343; rs11466321; rs1549934; rs10406816; rs11466334; rs11466349; rs10416269; rs11466353; rs8179182; rs13447341; rs35383147; rs11466358; rs11551225; rs11551223; rs12977601; rs12985978; rs13306707; rs11551226; rs36102838; rs13306706; rs35025994; rs12977628; rs13306708; rs11466354; rs11466330; rs7249191; rs35169655; rs11466327; rs11466355; rs8102918; rs9749548; rs12983775; rs5828100; rs3061187; rs41275752; rs12979815; rs35276753; rs35019416; rs3061188; rs2288875; rs3061192; rs5828102; rs28730295; rs12976890; rs35312206; rs11466333; rs33950017; rs11403932; rs11466340; rs11331966; rs3061190; rs2014015; rs11466328; rs11672143; rs35976994; rs5828101; rs11466346; rs10418010; rs8108632; rs35676663; rs35197353; rs11466352; rs11307639; rs11347492; rs12980944; rs11367425; rs36050346; rs34368921; rs8103575; rs11466350; rs11466342; rs12978333; rs11466320; rs11466348; rs41333448; rs34971127; rs11673275; rs11466336; rs28769597; rs11466339; rs5828099; rs10406316; rs12976219; rs34233206; rs10417924; rs1054797; rs11083616; rs11304; rs11668109; rs11668308; rs11669342; rs11879777; rs12980298; rs12980942; rs12981053; rs12983047; rs16959007; rs1800468; rs1800469; rs1800820; rs1982072; rs2241712; rs2241713; rs2241714; rs2241718; rs2241719; rs2241720; rs34088631; rs35135271; rs3810173; rs4803454; rs6957; rs7257310; rs7257742

# Macromolecular_Interacting_Partner_19_General_References:
3470709; 3861940; 8471846; 2982829; 3162913; 9150447; 11746498; 8424942; 8424943; 8679613; 9783545; 10973241; 11062463; 12202987; 12493741; 12843182

# Macromolecular_Interacting_Partner_19_References:
11208696; 12464353

# Macromolecular_Interacting_Partner_20_ID:
8193

# Macromolecular_Interacting_Partner_20_Name:
Atrial natriuretic factor precursor

# Macromolecular_Interacting_Partner_20_Synonyms:
ANF; Atrial natriuretic peptide; ANP; Prepronatriodilatin; CDD-ANF[Contains: Cardiodilatin-related peptide; CDP]

# Macromolecular_Interacting_Partner_20_Gene_Name:
NPPA

# Macromolecular_Interacting_Partner_20_Protein_Sequence:
>Atrial natriuretic factor precursor
MSSFSTTTVSFLLLLAFQLLGQTRANPMYNAVSNADLMDFKNLLDHLEEKMPLEDEVVPP
QVLSEPNEEAGAALSPLPEVPPWTGEVSPAQRDGGALGRGPWDSSDRSALLKSKLRALLT
APRSLRRSSCFGGRMDRIGAQSGLGCNSFRYRR

# Macromolecular_Interacting_Partner_20_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_20_Molecular_Weight:
16708

# Macromolecular_Interacting_Partner_20_Theoretical_pI:
7.27

# Macromolecular_Interacting_Partner_20_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_20_General_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Specific_Function:
A potent vasoactive substance which is thought to play a key role in cardiovascular homeostasis. Has a cGMP-stimulating activity

# Macromolecular_Interacting_Partner_20_Pathway:
Not Available

# Macromolecular_Interacting_Partner_20_Reaction:
Not Available

# Macromolecular_Interacting_Partner_20_Pfam_Domain_Function:
PF00212:ANP

# Macromolecular_Interacting_Partner_20_Signals:
1-25

# Macromolecular_Interacting_Partner_20_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_20_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_20_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_20_GenBank_ID_Protein:
178630

# Macromolecular_Interacting_Partner_20_SwissProt_ID:
ANF_HUMAN (P01160)

# Macromolecular_Interacting_Partner_20_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_20_Genecard_id:
NPPA

# Macromolecular_Interacting_Partner_20_Geneatlas_id:
NPPA

# Macromolecular_Interacting_Partner_20_hgnc_id:
HGNC:7939

# Macromolecular_Interacting_Partner_20_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_20_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_20_Gene_Sequence:
>456 bp
ATGAGCTCCTTCTCCACCACCACCGTGAGCTTCCTCCTTTTACTGGCATTCCAGCTCCTA
GGTCAGACCAGAGCTAATCCCATGTACAATGCCGTGTCCAACGCAGACCTGATGGATTTC
AAGAATTTGCTGGACCATTTGGAAGAAAAGATGCCTTTAGAAGATGAGGTCGTGCCCCCA
CAAGTGCTCAGTGAGCCGAATGAAGAAGCGGGGGCTGCTCTCAGCCCCCTCCCTGAGGTG
CCTCCCTGGACCGGGGAAGTCAGCCCAGCCCAGAGAGATGGAGGTGCCCTCGGGCGGGGC
CCCTGGGACTCCTCTGATCGATCTGCCCTCCTAAAAAGCAAGCTGAGGGCGCTGCTCACT
GCCCCTCGGAGCCTGCGGAGATCCAGCTGCTTCGGGGGCAGGATGGACAGGATTGGAGCC
CAGAGCGGACTGGGCTGTAACAGCTTCCGGTACTGA

# Macromolecular_Interacting_Partner_20_GenBank_ID_Gene:
K02043

# Macromolecular_Interacting_Partner_20_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_20_Locus:
1p36.21

# Macromolecular_Interacting_Partner_20_SNPs:
rs5063; rs5065; rs5067; rs5066; rs5068; rs5064; rs198368; rs198367; rs198365; rs198369; rs198366; rs12744433; rs198364; rs198359; rs198358; rs17376426; rs198361; rs198357; rs7552330; rs198372; rs198360; rs198373; rs13305986; rs1803268; rs13305987; rs3170926; rs12565; rs1049827; rs11121835; rs198370; rs12744757; rs35427399; rs41300100; rs12723768; rs41275508; rs41307784; rs6695740; rs35183869; rs5772478; rs17037488; rs1003632; rs12024265; rs1023252; rs11802855; rs12029160; rs12047640; rs12091159; rs12567204; rs14078; rs169158; rs171983; rs17350396; rs198375; rs198381; rs198387; rs198388; rs198402; rs198403; rs198404; rs198405; rs198406; rs198408; rs198409; rs198410; rs198411; rs198412; rs198413; rs198414; rs198415; rs2075538; rs2075539; rs2272802; rs2272803; rs632793; rs6541007; rs6668352; rs6694164; rs7412854

# Macromolecular_Interacting_Partner_20_General_References:
6203042; 6547996; 6095118; 6095119; 6542248; 3158606; 6097248; 6238331; 6230082; 1826098; 8043577

# Macromolecular_Interacting_Partner_20_References:
10373213; 10614654; 12403658; 1649942

# Macromolecular_Interacting_Partner_21_ID:
8137

# Macromolecular_Interacting_Partner_21_Name:
Mineralocorticoid receptor

# Macromolecular_Interacting_Partner_21_Synonyms:
MR

# Macromolecular_Interacting_Partner_21_Gene_Name:
NR3C2

# Macromolecular_Interacting_Partner_21_Protein_Sequence:
>Mineralocorticoid receptor
METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST
QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE
QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAI
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN
AENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP
ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD
SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF
DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR
DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS
KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL
QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN
TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV
VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML
VEIISDQLPKVESGNAKPLYFHRK

# Macromolecular_Interacting_Partner_21_Number_of_Residues:
984

# Macromolecular_Interacting_Partner_21_Molecular_Weight:
107068

# Macromolecular_Interacting_Partner_21_Theoretical_pI:
7.42

# Macromolecular_Interacting_Partner_21_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_21_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_21_Specific_Function:
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels

# Macromolecular_Interacting_Partner_21_Pathway:
Not Available

# Macromolecular_Interacting_Partner_21_Reaction:
Not Available

# Macromolecular_Interacting_Partner_21_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_21_Signals:
None

# Macromolecular_Interacting_Partner_21_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_21_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_21_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_21_GenBank_ID_Protein:
307166

# Macromolecular_Interacting_Partner_21_SwissProt_ID:
MCR_HUMAN (P08235)

# Macromolecular_Interacting_Partner_21_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_21_Genecard_id:
NR3C2

# Macromolecular_Interacting_Partner_21_Geneatlas_id:
NR3C2

# Macromolecular_Interacting_Partner_21_hgnc_id:
HGNC:7979

# Macromolecular_Interacting_Partner_21_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_21_Subcellular_Location:
Cytoplasm. Nucleus. Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane

# Macromolecular_Interacting_Partner_21_Gene_Sequence:
>2955 bp
ATGGAGACCAAAGGCTACCACAGTCTCCCTGAAGGTCTAGATATGGAAAGACGGTGGGGT
CAAGTTTCTCAGGCTGTGGAGCGTTCTTCCCTGGGACCTACAGAGAGGACCGATGAGAAT
AACTACATGGAGATTGTCAACGTAAGCTGTGTTTCCGGTGCTATTCCAAACAACAGTACT
CAAGGAAGCAGCAAAGAAAAACAAGAACTACTCCCTTGCCTTCAGCAAGACAATAATCGG
CCTGGGATTTTAACATCTGATATTAAAACTGAGCTGGAATCTAAGGAACTTTCAGCAACT
GTAGCTGAGTCCATGGGTTTATATATGGATTCTGTAAGAGATGCTGACTATTCCTATGAG
CAGCAGAACCAACAAGGAAGCATGAGTCCAGCTAAGATTTATCAGAATGTTGAACAGCTG
GTGAAATTTTACAAAGGAAATGGCCATCGTCCTTCCACTCTAAGTTGTGTGAACACGCCC
TTGAGATCATTTATGTCTGACTCTGGGAGCTCCGTGAATGGTGGCGTCATGCGCGCCATT
GTTAAAAGCCCTATCATGTGTCATGAGAAAAGCCCGTCTGTTTGCAGCCCTCTGAACATG
ACATCTTCGGTTTGCAGCCCTGCTGGAATCAACTCTGTGTCCTCCACCACAGCCAGCTTT
GGCAGTTTTCCAGTGCACAGCCCAATCACCCAGGGAACTCCTCTGACATGCTCCCCTAAT
GCTGAAAATCGAGGCTCCAGGTCGCACAGCCCTGCACATGCTAGCAATGTGGGCTCTCCT
CTCTCAAGTCCGTTAAGTAGCATGAAATCCTCAATTTCCAGCCCTCCAAGTCACTGCAGT
GTAAAATCTCCAGTCTCCAGTCCCAATAATGTCACTCTGAGATCCTCTGTGTCTAGCCCT
GCAAATATTAACAACTCAAGGTGCTCTGTTTCCAGCCCTTCGAACACTAATAACAGATCC
ACGCTTTCCAGTCCGGCAGCCAGTACTGTGGGATCTATCTGTAGCCCTGTAAACAATGCC
TTCAGCTACACTGCTTCTGGCACCTCTGCTGGATCCAGTACATTGCGGGATGTGGTTCCC
AGTCCAGACACGCAGGAGAAAGGTGCTCAAGAGGTCCCTTTTCCTAAGACTGAGGAAGTA
GAGAGTGCCATCTCAAATGGTGTGACTGGCCAGCTTAATATTGTCCAGTACATAAAACCA
GAACCAGATGGAGCTTTTAGCAGCTCATGTCTAGGAGGAAATAGCAAAATAAATTCGGAT
TCTTCATTCTCAGTACCAATAAAGCAAGAATCAACCAAGCATTCATGTTCAGGCACCTCT
TTTAAAGGGAATCCAACAGTAAACCCGTTTCCATTTATGGATGGCTCGTATTTTTCCTTT
ATGGATGATAAAGACTATTATTCCCTATCAGGAATTTTAGGACCACCTGTGCCCGGCTTT
GATGGTAACTGTGAAGGCAGCGGATTCCCAGTGGGTATTAAACAAGAACCAGATGACGGG
AGCTATTACCCAGAGGCCAGCATCCCTTCCTCTGCTATTGTTGGGGTGAATTCAGGTGGA
CAGTCCTTCCACTACAGGATTGGTGCTCAAGGTACAATATCTTTATCACGATCGGCTAGA
GACCAATCTTTCCAACACCTGAGTTCCTTTCCTCCTGTCAATACTTTAGTGGAGTCATGG
AAATCACACGGCGACCTGTCGTCTAGAAGAAGTGATGGGTATCCGGTCTTAGAATACATT
CCAGAAAATGTATCAAGCTCTACTTTACGAAGTGTTTCTACTGGATCTTCAAGACCTTCA
AAAATATGTTTGGTGTGTGGGGATGAGGCTTCAGGATGCCATTATGGGGTAGTCACCTGT
GGCAGCTGCAAAGTTTTCTTCAAAAGAGCAGTGGAAGGGCAACACAACTATTTATGTGCT
GGAAGAAATGATTGCATCATTGATAAGATTCGACGAAAGAATTGTCCTGCTTGCAGACTT
CAGAAATGTCTTCAAGCTGGAATGAATTTAGGAGCACGAAAGTCAAAGAAGTTGGGAAAG
TTAAAAGGGATTCACGAGGAGCAGCCACAGCAGCAGCAGCCCCCACCCCCACCCCCACCC
CCGCAAAGCCCAGAGGAAGGGACAACGTACATCGCTCCTGCAAAAGAACCCTCGGTCAAC
ACAGCACTGGTTCCTCAGCTCTCCACAATCTCACGAGCGCTCACACCTTCCCCCGTTATG
GTCCTTGAAAACATTGAACCTGAAATTGTATATGCAGGCTATGACAGCTCAAAACCAGAT
ACAGCCGAAAATCTGCTCTCCACGCTCAACCGCTTAGCAGGCAAACAGATGATCCAAGTC
GTGAAGTGGGCAAAGGTACTTCCAGGATTTAAAAACTTGCCTCTTGAGGACCAAATTACC
CTAATCCAGTATTCTTGGATGTGTCTATCATCATTTGCCTTGAGCTGGAGATCGTACAAA
CATACGAACAGCCAATTTCTCTATTTTGCACCAGACCTAGTCTTTAATGAAGAGAAGATG
CATCAGTCTGCCATGTATGAACTATGCCAGGGGATGCACCAAATCAGCCTTCAGTTCGTT
CGACTGCAGCTCACCTTTGAAGAATACACCATCATGAAAGTTTTGCTGCTACTAAGCACA
ATTCCAAAGGATGGCCTCAAAAGCCAGGCTGCATTTGAAGAAATGAGGACAAATTACATC
AAAGAACTGAGGAAGATGGTAACTAAGTGTCCCAACAATTCTGGGCAGAGCTGGCAGAGG
TTCTACCAACTGACCAAGCTGCTGGACTCCATGCATGACCTGGTGAGCGACCTGCTGGAA
TTCTGCTTCTACACCTTCCGAGAGTCCCATGCGCTGAAGGTAGAGTTCCCCGCAATGCTG
GTGGAGATCATCAGCGACCAGCTGCCCAAGGTGGAGTCGGGGAACGCCAAGCCGCTCTAC
TTCCACCGGAAGTGA

# Macromolecular_Interacting_Partner_21_GenBank_ID_Gene:
M16801

# Macromolecular_Interacting_Partner_21_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_21_Locus:
4q31.1

# Macromolecular_Interacting_Partner_21_SNPs:
rs5522; rs5527; rs12509135; rs5523; rs13306592; rs5525; rs5529; rs5524; rs5528; rs2070949; rs2871; rs5534; rs7658048; rs5536; rs2070951; rs2070950; rs5530; rs17024360; rs6814934; rs5533; rs5535; rs5537; rs5532; rs6822758; rs1879828; rs1994624; rs1512327; rs1403142; rs1512341; rs1532890; rs1512342; rs2063009; rs1546529; rs1403143; rs907620; rs2137335; rs1546531; rs2137330; rs2163172; rs993386; rs1879829; rs6857487; rs7668847; rs3910047; rs4835514; rs1512329; rs3920217; rs4835479; rs6812904; rs6857011; rs6844155; rs6535594; rs1040288; rs6823544; rs2063556; rs878152; rs3846309; rs11724226; rs6840127; rs10012553; rs7693776; rs6840141; rs10032020; rs4835128; rs1913023; rs11723856; rs6848375; rs6844424; rs3910054; rs2883929; rs4835486; rs10026568; rs7695118; rs12649394; rs4835500; rs6535581; rs2884445; rs3846307; rs7438918; rs13133240; rs9993133; rs6820751; rs1512332; rs6535590; rs6856803; rs3857084; rs11099695; rs4835485; rs3752701; rs12499873; rs3910056; rs6810951; rs3843411; rs6850597; rs11736161; rs10857231; rs3843410; rs2356210; rs9997090; rs6811001; rs6535583; rs3846329; rs3846318; rs4835494; rs1512337; rs10010766; rs4835488; rs6832421; rs907618; rs2048546; rs1858416; rs6535599; rs4835478; rs2272089; rs3846319; rs879206; rs11099690; rs13133379; rs6847959; rs7677409; rs1818448; rs3846302; rs1512344; rs7661835; rs1879827; rs6831376; rs11099680; rs4835490; rs6535580; rs13105361; rs1355613; rs6535597; rs3846306; rs10434100; rs4027073; rs6856424; rs7665528; rs4635799; rs4835516; rs3846317; rs6535598; rs6832393; rs6535584; rs6815984; rs2293162; rs10011595; rs3846322; rs2063555; rs11929719; rs3910044; rs1512343; rs13103641; rs6535577; rs1490453; rs2048547; rs6820304; rs13116347; rs7696770; rs6535579; rs12512126; rs7670229; rs10023128; rs907619; rs6535602; rs4835519; rs3931397; rs2137334; rs7691663; rs6828665; rs2883930; rs907621; rs6825530; rs10519942; rs11099681; rs6828378; rs745019; rs17024708; rs11725509; rs13117325; rs1987969; rs3910052; rs11937655; rs12511893; rs12647605; rs6849127; rs6849903; rs12711259; rs6849862; rs3846316; rs11733930; rs6854515; rs17024387; rs17581884; rs6817983; rs6817925; rs7693171; rs12641471; rs6535588; rs11736713; rs4835133; rs13147775; rs6535593; rs10050229; rs10018805; rs17484259; rs3925570; rs4087964; rs3846328; rs1512326; rs4835508; rs10026226; rs4835506; rs12711260; rs6831034; rs13137823; rs12506077; rs2063554; rs3887856; rs7691250; rs11099679; rs17620160; rs7670069; rs12507494; rs17620330; rs16998733; rs4835491; rs6826213; rs7680420; rs745020; rs12506058; rs11945778; rs17024397; rs6846614; rs13116332; rs9996961; rs4513547; rs17620775; rs6535596; rs12651282; rs3916013; rs12498662; rs10021848; rs3846312; rs11734888; rs10519945; rs992556; rs9631756; rs17484454; rs12499208; rs17483854; rs6816503; rs10519959; rs10034789; rs3846305; rs10004472; rs4594704; rs4087965; rs4260521; rs1546044; rs12640639; rs7694064; rs12508913; rs17620822; rs2358243; rs13112423; rs3846325; rs6831887; rs10031992; rs7698302; rs10519952; rs10031538; rs7694706; rs17581311; rs6826471; rs11735947; rs6826594; rs3911846; rs3910046; rs13150372; rs10519955; rs7683540; rs7673644; rs13137836; rs1512330; rs4835493; rs10434130; rs12642178; rs4087963; rs7655438; rs1398269; rs11728254; rs6813167; rs7698307; rs4835504; rs17024456; rs2137331; rs4835482; rs17024654; rs13119790; rs2883917; rs11732490; rs2063553; rs3846320; rs17483391; rs6857716; rs7670173; rs11733686; rs4579099; rs1996025; rs3843413; rs3846301; rs17620105; rs9997336; rs6851669; rs4835131; rs17484357; rs11946576; rs10519951; rs3733421; rs7683313; rs6839414; rs17484671; rs3910051; rs10024999; rs11099692; rs17483979; rs6855032; rs4083100; rs10519963; rs17024482; rs2063557; rs13142954; rs7693077; rs4835138; rs6814226; rs10031194; rs1522451; rs13146357; rs17484873; rs3910053; rs6831212; rs11099678; rs3846326; rs12331321; rs6834935; rs6825048; rs6813869; rs11724292; rs6823323; rs11731398; rs10519954; rs17483833; rs9991002; rs3857079; rs10033040; rs10032250; rs6849817; rs4835484; rs7661326; rs1512331; rs4835503; rs10519958; rs4835483; rs6535600; rs3910057; rs3846321; rs17484678; rs11730274; rs13116524; rs11737660; rs13144030; rs6818452; rs7699349; rs6836191; rs1512335; rs2358336; rs17024443; rs11726964; rs3846299; rs1429915; rs7672951; rs4835136; rs17024479; rs10002896; rs17024514; rs1911120; rs2137332; rs10519962; rs13123626; rs4835497; rs2115800; rs10026826; rs6836072; rs11099677; rs17024718; rs17484783; rs13116099; rs12639977; rs7670121; rs6819635; rs17024666; rs17582206; rs11721992; rs10857232; rs11943992; rs10025629; rs11932750; rs12511415; rs6813390; rs3846300; rs12510074; rs13118475; rs17024611; rs17484811; rs17024683; rs17024380; rs3857083; rs11933180; rs17024408; rs4835512; rs12506066; rs17580772; rs6836246; rs17582031; rs11099688; rs11730626; rs17024706; rs6849327; rs9761994; rs3846313; rs17483701; rs17485033; rs7666711; rs11731400; rs9762822; rs6846738; rs17024633; rs9685254; rs6857339; rs17024541; rs13129830; rs3910058; rs7668671; rs11099686; rs12500487; rs7673925; rs765491; rs12499901; rs7686433; rs3910060; rs2172002; rs17581262; rs7690849; rs6833880; rs17024678; rs10034882; rs17581570; rs4560389; rs17484839; rs17024631; rs9994262; rs7698917; rs17581787; rs6816918; rs7687754; rs11736341; rs17484118; rs2137336; rs7694200; rs11099689; rs12647354; rs17024704; rs2137333; rs17484622; rs17581815; rs1964691; rs17484447; rs17484245; rs9995951; rs1398268; rs17024437; rs13146865; rs6822617; rs12502713; rs7665347; rs17024516; rs1512336; rs9994862; rs13148853; rs17007968; rs6843485; rs17484601; rs17024518; rs1429914; rs3846323; rs17581905; rs7698289; rs2883879; rs9685269; rs4091074; rs9760992; rs6850820; rs9683768; rs9685938; rs11099694; rs11931777; rs17024512; rs1512334; rs11939588; rs9761239; rs17581605; rs7700126; rs9992964; rs17024364; rs6829058; rs3846308; rs11729617; rs6535592; rs17024509; rs17024506; rs13137095; rs1858415; rs7442442; rs17024717; rs6840422; rs3846310; rs11932031; rs11722863; rs2056471; rs6858581; rs12504040; rs10026186; rs17581220; rs6535578; rs6841404; rs9990620; rs13133487; rs13109933; rs7690778; rs7689925; rs17621119; rs2356374; rs17024579; rs3857082; rs13150785; rs11099683; rs6846591; rs4835487; rs2048548; rs17024720; rs17024469; rs6832062; rs17581975; rs10034617; rs4835502; rs6846217; rs11721799; rs13108130; rs10012907; rs7688969; rs1512328; rs17024715; rs17024681; rs10857233; rs1877445; rs6854045; rs17484063; rs11099687; rs11099685; rs7682972; rs9685272; rs4835505; rs10010607; rs10033445; rs4301087; rs11931989; rs4835513; rs3846304; rs11732130; rs3910059; rs1033123; rs3910055; rs12508062; rs35644313; rs13118022; rs6855341; rs34861534; rs11727894; rs17580954; rs10001430; rs17024404; rs907617; rs17484991; rs7688209; rs12648444; rs17581996; rs12645409; rs1949169; rs6844150; rs6857670; rs11722067; rs3846315; rs13116551; rs17024560; rs11099696; rs7658039; rs11936376; rs878232; rs7698965; rs4835129; rs11725360; rs17024401; rs17024556; rs1980278; rs10009023; rs10434128; rs17376692; rs6856000; rs9995276; rs6841570; rs6842079; rs4835489; rs12509783; rs17676810; rs10519948; rs6853764; rs10011581; rs17581898; rs6851178; rs7690691; rs17581947; rs9998790; rs7692281; rs1522450; rs3857080; rs6854097; rs6846376; rs17483687; rs17024565; rs7674206; rs3910050; rs12506373; rs10029951; rs17581115; rs6812538; rs1873174; rs7696997; rs6836320; rs2301280; rs11936965; rs17024347; rs2248038; rs13306591; rs41511344; rs5526; rs34905604; rs5531; rs6848862; rs35832836; rs35396139; rs6823133; rs10708334; rs12643841; rs1062595; rs35360139; rs35586342; rs10028821; rs11292717; rs1062596; rs34293064; rs2070948; rs34347300; rs35771619; rs17580982; rs28549338; rs34802206; rs34026733; rs35713600; rs35258027; rs35789402; rs35606529; rs3054606; rs11730006; rs34476486; rs10562720; rs13138913; rs35132207; rs5862831; rs4505803; rs7668619; rs34734628; rs3910049; rs11939631; rs13144019; rs34471942; rs28647457; rs28594566; rs28656810; rs11384270; rs34886346; rs13139652; rs34030364; rs1946524; rs10021521; rs7699303; rs33936062; rs34054905; rs13149418; rs11381991; rs34431006; rs6815979; rs34953252; rs7674857; rs17580639; rs35590380; rs34165580; rs35135883; rs11940423; rs34244163; rs35978319; rs17024635; rs13112076; rs3887324; rs1512333; rs28672384; rs35224048; rs9993593; rs35237809; rs35378267; rs35436474; rs981372; rs3857081; rs13104218; rs5862829; rs35681362; rs13121960; rs34159127; rs3843414; rs9631755; rs36034042; rs5862838; rs7699209; rs35201774; rs36182734; rs35264279; rs11378484; rs35714983; rs35933180; rs35464072; rs35423790; rs28605213; rs11930469; rs35186171; rs1522449; rs11332546; rs10605309; rs6822304; rs9762356; rs6829009; rs4501202; rs35976575; rs2137338; rs11381917; rs1522452; rs9997290; rs35907005; rs35562931; rs11416123; rs13108703; rs34987101; rs34152444; rs34611880; rs35337326; rs34236655; rs35111299; rs3846330; rs28441385; rs7679518; rs33937448; rs3846303; rs35282722; rs35595748; rs17620469; rs28377603; rs35809828; rs4027074; rs6839408; rs11733477; rs5862833; rs34529215; rs35563216; rs17024667; rs34997890; rs34279352; rs4835515; rs35480965; rs3846327; rs11944891; rs2293163; rs33971837; rs28379421; rs35496556; rs34440852; rs6826827; rs28698626; rs6852036; rs35126311; rs35152746; rs28465033; rs11361774; rs36135256; rs1946523; rs10026777; rs7678106; rs35607293; rs2115798; rs35549271; rs7680091; rs34975695; rs7682465; rs35198554; rs13112089; rs34530174; rs10034839; rs34469488; rs10716270; rs28805917; rs35947630; rs4447838; rs4835501; rs28372032; rs7678425; rs35095537; rs6815139; rs28367185; rs3843412; rs35190729; rs34364416; rs35944210; rs35557372; rs4835137; rs1355612; rs6535591; rs10003237; rs1546530; rs7673832; rs35827730; rs11362297; rs34296798; rs35058866; rs35315376; rs33962250; rs28798239; rs34298854; rs28698266; rs11349017; rs34206536; rs2356394; rs11725517; rs13132072; rs7691775; rs13137655; rs34453040; rs28639664; rs13111594; rs36012041; rs34621287; rs13434549; rs11386119; rs33973334; rs28723458; rs35806661; rs11099682; rs13108682; rs11935760; rs28837820; rs13132300; rs6815356; rs17024561; rs3045289; rs35258207; rs35591475; rs28702892; rs35992616; rs36196281; rs28604902; rs34170216; rs13137039; rs34489084; rs4295241; rs6819902; rs34825669; rs28462077; rs36032097; rs4621409; rs10434129; rs11723538; rs12641579; rs35653840; rs11343039; rs926019; rs9997923; rs4122853; rs982076; rs13104030; rs35344401; rs12647673; rs13133177; rs35283376; rs35263055; rs6846848; rs6840172; rs28633715; rs6819706; rs35745299; rs34782286; rs5862834; rs5862828; rs7659754; rs7693371; rs35041849; rs6817070; rs12639699; rs34440621; rs36112050; rs34599173; rs28621626; rs11936509; rs10593353; rs35161508; rs35920138; rs3846311; rs35304305; rs34043561; rs28693507; rs4122851; rs28487903; rs13104472; rs9762359; rs35691150; rs13119744; rs11418057; rs34120297; rs11325949; rs965333; rs11326129; rs4026975; rs28869632; rs34643750; rs35003454; rs3846314; rs34966836; rs41510346; rs11444261; rs34113900; rs11303019; rs13138584; rs28482137; rs4027011; rs4293768; rs35554261; rs10528442; rs4835135; rs5862836; rs11459183; rs13118302; rs11440077; rs9992528; rs11323955; rs9654229; rs34090627; rs35633620; rs2102324; rs17304693; rs6838741; rs10586000; rs28789690; rs35476181; rs10654553; rs10624932; rs6833414; rs28645256; rs28834470; rs13132292; rs2358393; rs13139639; rs2358391; rs35101629; rs11724707; rs35649035; rs6831382; rs35957063; rs28367516; rs35414407; rs13105220; rs35574035; rs28408866; rs35013118; rs6535601; rs33924907; rs35672392; rs35706591; rs1033124; rs10023233; rs10025943; rs28377573; rs10650773; rs1911121; rs35087243; rs13104077; rs7670108; rs17024702; rs33913235; rs34874638; rs35954987; rs28663510; rs35637413; rs13120238; rs34771380; rs7678730; rs35697753; rs10008590; rs28593291; rs6535589; rs35210835; rs34273091; rs12507179; rs3053707; rs11363070; rs34012726; rs35945803; rs9993239; rs34416910; rs35504843; rs13145279; rs3927189; rs34311799; rs35146790; rs35181235; rs4835134; rs9992738; rs34374593; rs35318150; rs3752699; rs28588362; rs10607471; rs35749628; rs35992633; rs6854073; rs34815731; rs34799906; rs34810874; rs7668163; rs6535595; rs28711864; rs35264971; rs6814250; rs28369259; rs11940211; rs35083876; rs13144897; rs11320471; rs13127625; rs7438191; rs33955319; rs6148713; rs35899657; rs13129427; rs9994070; rs2137337; rs3910045; rs3045291; rs28408757; rs7375748; rs34408397; rs34019225; rs6852213; rs13136461; rs34980641; rs28802981; rs28542380; rs7661019; rs13132447; rs4835496; rs34189207; rs7685078; rs11365652; rs11947170; rs35303613; rs11324908; rs11731514; rs4613545; rs34201038; rs35227232; rs1039661; rs5862830; rs1913024; rs10019500; rs28886306; rs28505258; rs13123890; rs36193232; rs12650807; rs35870945; rs35700532; rs10050039; rs28376416; rs1057582; rs34880037; rs17024607; rs13149615; rs34890688; rs9994750; rs2884444; rs3857078; rs34704824; rs28648617; rs4122852; rs28612659; rs2356396; rs13104128; rs34636256; rs13136278; rs35441871; rs36048118; rs28657475; rs3846324; rs6823228; rs36084095; rs10857229; rs13107326; rs34499764; rs4027071; rs7670548; rs36145086; rs36150442; rs35832966; rs34625634; rs11330551; rs3041314; rs11363007; rs2115799; rs10648420; rs10008249; rs13142928; rs28464586; rs35591857; rs35550474; rs35903741; rs13146516; rs34946425; rs10564985; rs35545904; rs7377312; rs6854734; rs35593495; rs7668604; rs13119375; rs6818829; rs34936098; rs34272449; rs10434126; rs36036329; rs13112083; rs35000747; rs4611905; rs36084759; rs6827966; rs35940027; rs5862832; rs35659747; rs34400301; rs6831307; rs1512338; rs34618929; rs11324608; rs9999121; rs33928091; rs35667348; rs13109808; rs1506485; rs34896196; rs34217783; rs28407287; rs4835130; rs34576468; rs35162529; rs13133715; rs34220553; rs36127895; rs28368806; rs34718720; rs10593354; rs34580575; rs11727220; rs6854552; rs10026691; rs9995733; rs34168257; rs13115808; rs10608177; rs13134017; rs13103165; rs7438145; rs13106019; rs35504492; rs1512325; rs11384324; rs4560386; rs35925584; rs28696868; rs36041499; rs13137647; rs28897121; rs35642551; rs28507515; rs34868943; rs34430699; rs34051019; rs11722362; rs13132931; rs28622386; rs34346258; rs34696054; rs12511445; rs34317333; rs28391722; rs11386118; rs35741966; rs2356395; rs34642043; rs13109056; rs35311918; rs35979588; rs28529230; rs1429913; rs34163190; rs11335509; rs7656855; rs13104051; rs35367551; rs3045288; rs35932147; rs4835495; rs6839999; rs34372017; rs36114978; rs2358392; rs3906618; rs13125410; rs958785; rs13129690; rs4413384; rs36047772; rs35681147; rs995567; rs34623514; rs35762686; rs3902512; rs6846368; rs9993590; rs35118070; rs13139638; rs2037480; rs34918298; rs35694427; rs7682951; rs6852299; rs35541483; rs28851025; rs28498606; rs35070877; rs2356393; rs35820273; rs34948284; rs2174607; rs34358139; rs6841588; rs35325933; rs13133533; rs1398267; rs34152264; rs3910048; rs34438391; rs6840095; rs35756472; rs13114315; rs11377568; rs35022514; rs1512340; rs35079121; rs28500506; rs28398455; rs12331046; rs10542552; rs34209795; rs5862837; rs35441978; rs10012283; rs28696003; rs35542382; rs11726122; rs34294859; rs35115274; rs35534927; rs28770279; rs35338709; rs34927488; rs6854559; rs10034151; rs28452605; rs5862835; rs28848778; rs28607266; rs3216799; rs13306590; rs885859; rs34063900; rs6834026; rs7672177; rs34064829; rs885858; rs34022568; rs7671250; rs28742132; rs10689483; rs34706003; rs10213471; rs1039662; rs1039663; rs11099676; rs11728788; rs11933330; rs11933380; rs12499434; rs12641566; rs13111300; rs13141425; rs13148438; rs1490464; rs1490465; rs1546043; rs17024337; rs1907076; rs34158761; rs35815539; rs3884525; rs5521; rs6824449; rs7377816; rs906124; rs9307847; rs9724

# Macromolecular_Interacting_Partner_21_General_References:
3037703; 11518808; 9662404; 1655735; 7495694; 9141514; 9392437; 9724527; 10760050; 10935545; 11350956; 10391210; 11134129; 10884226; 12483305

# Macromolecular_Interacting_Partner_21_References:
11858800; 12852254; 12933324; 16393154

# Macromolecular_Interacting_Partner_22_ID:
8170

# Macromolecular_Interacting_Partner_22_Name:
Vascular cell adhesion protein 1 precursor

# Macromolecular_Interacting_Partner_22_Synonyms:
V-CAM 1; CD106 antigen; INCAM-100

# Macromolecular_Interacting_Partner_22_Gene_Name:
VCAM1

# Macromolecular_Interacting_Partner_22_Protein_Sequence:
>Vascular cell adhesion protein 1 precursor
MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR
TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE
IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV
TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG
SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN
RKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVR
SEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSS
VTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKA
LVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFP
APKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP
KDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQL
KDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFA
RKANMKGSYSLVEAQKSKV

# Macromolecular_Interacting_Partner_22_Number_of_Residues:
739

# Macromolecular_Interacting_Partner_22_Molecular_Weight:
81277

# Macromolecular_Interacting_Partner_22_Theoretical_pI:
4.87

# Macromolecular_Interacting_Partner_22_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular process
Process:  cell adhesion
Process:  cell-cell adhesion
 ||
>>>
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_22_General_Function:
Not Available

# Macromolecular_Interacting_Partner_22_Specific_Function:
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation

# Macromolecular_Interacting_Partner_22_Pathway:
Not Available

# Macromolecular_Interacting_Partner_22_Reaction:
Not Available

# Macromolecular_Interacting_Partner_22_Pfam_Domain_Function:
PF05790:C2-set;
PF07679:I-set;
PF00047:ig;
PF07686:V-set

# Macromolecular_Interacting_Partner_22_Signals:
1-24

# Macromolecular_Interacting_Partner_22_Transmembrane_Regions:
699-720

# Macromolecular_Interacting_Partner_22_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_22_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_22_GenBank_ID_Protein:
179886

# Macromolecular_Interacting_Partner_22_SwissProt_ID:
VCAM1_HUMAN (P19320)

# Macromolecular_Interacting_Partner_22_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_22_Genecard_id:
VCAM1

# Macromolecular_Interacting_Partner_22_Geneatlas_id:
VCAM1

# Macromolecular_Interacting_Partner_22_hgnc_id:
HGNC:12663

# Macromolecular_Interacting_Partner_22_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_22_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_22_Gene_Sequence:
>1944 bp
ATGCCTGGGAAGATGGTCGTGATCCTTGGAGCCTCAAATATACTTTGGATAATGTTTGCA
GCTTCTCAAGCTTTTAAAATCGAGACCACCCCAGAATCTAGATATCTTGCTCAGATTGGT
GACTCCGTCTCATTGACTTGCAGCACCACAGGCTGTGAGTCCCCATTTTTCTCTTGGAGA
ACCCAGATAGATAGTCCACTGAATGGGAAGGTGACGAATGAGGGGACCACATCTACGCTG
ACAATGAATCCTGTTAGTTTTGGGAACGAACACTCTTACCTGTGCACAGCAACTTGTGAA
TCTAGGAAATTGGAAAAAGGAATCCAGGTGGAGATCTACTCTTTTCCTAAGGATCCAGAG
ATTCATTTGAGTGGCCCTCTGGAGGCTGGGAAGCCGATCACAGTCAAGTGTTCAGTTGCT
GATGTATACCCATTTGACAGGCTGGAGATAGACTTACTGAAAGGAGATCATCTCATGAAG
AGTCAGGAATTTCTGGAGGATGCAGACAGGAAGTCCCTGGAAACCAAGAGTTTGGAAGTA
ACCTTTACTCCTGTCATTGAGGATATTGGAAAAGTTCTTGTTTGCCGAGCTAAATTACAC
ATTGATGAAATGGATTCTGTGCCCACAGTAAGGCAGGCTGTAAAAGAATTGCAAGTCTAC
ATATCACCCAAGAATACAGTTATTTCTGTGAATCCATCCACAAAGCTGCAAGAAGGTGGC
TCTGTGACCATGACCTGTTCCAGCGAGGGTCTACCAGCTCCAGAGATTTTCTGGAGTAAG
AAATTAGATAATGGGAATCTACAGCACCTTTCTGGAAATGCAACTCTCACCTTAATTGCT
ATGAGGATGGAAGATTCTGGAATTTATGTGTGTGAAGGAGTTAATTTGATTGGGAAAAAC
AGAAAAGAGGTGGAATTAATTGTTCAAGCATTCCCTAGAGATCCAGAAATCGAGATGAGT
GGTGGCCTCGTGAATGGGAGCTCTGTCACTGTAAGCTGCAAGGTTCCTAGCGTGTACCCC
CTTGACCGGCTGGAGATTGAATTACTTAAGGGGGAGACTATTCTGGAGAATATAGAGTTT
TTGGAGGATACGGATATGAAATCTCTAGAGAACAAAAGTTTGGAAATGACCTTCATCCCT
ACCATTGAAGATACTGGAAAAGCTCTTGTTTGTCAGGCTAAGTTACATATTGATGACATG
GAATTCGAACCCAAACAAAGGCAGAGTACGCAAACACTTTATGTCAATGTTGCCCCCAGA
GATACAACCGTCTTGGTCAGCCCTTCCTCCATCCTGGAGGAAGGCAGTTCTGTGAATATG
ACATGCTTGAGCCAGGGCTTTCCTGCTCCGAAAATCCTGTGGAGCAGGCAGCTCCCTAAC
GGGGAGCTACAGCCTCTTTCTGAGAATGCAACTCTCACCTTAATTTCTACAAAAATGGAA
GATTCTGGGGTTTATTTATGTGAAGGAATTAACCAGGCTGGAAGAAGCAGAAAGGAAGTG
GAATTAATTATCCAAGTTACTCCAAAAGACATAAAACTTACAGCTTTTCCTTCTGAGAGT
GTCAAAGAAGGAGACACTGTCATCATCTCTTGTACATGTGGAAATGTTCCAGAAACATGG
ATAATCCTGAAGAAAAAAGCGGAGACAGGAGACACAGTACTAAAATCTATAGATGGCGCC
TATACCATCCGAAAGGCCCAGTTGAAGGATGCGGGAGTATATGAATGTGAATCTAAAAAC
AAAGTTGGCTCACAATTAAGAAGTTTAACACTTGATGTTCAAGGAAGAGAAAACAACAAA
GACTATTTTTCTCCTGAGCTTCTCGTGCTCTATTTTGCATCCTCCTTAATAATACCTGCC
ATTGGAATGATAATTTACTTTGCAAGAAAAGCCAACATGAAGGGGTCATATAGTCTTGTA
GAAGCACAGAAATCAAAAGTGTAG

# Macromolecular_Interacting_Partner_22_GenBank_ID_Gene:
M30257

# Macromolecular_Interacting_Partner_22_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_22_Locus:
1p32-p31

# Macromolecular_Interacting_Partner_22_SNPs:
rs3783613; rs3783612; rs3783611; rs3783615; rs34100871; rs34228330; rs34199378; rs3176879; rs3176878; rs3783621; rs3783618; rs3783617; rs3783608; rs3783609; rs3783619; rs3783610; rs3783607; rs3176875; rs3176860; rs3176874; rs3176876; rs3917012; rs2392221; rs3181088; rs3765685; rs3819950; rs3917041; rs3176870; rs3917040; rs3176861; rs3917037; rs2209627; rs3176862; rs3917067; rs3176869; rs3917016; rs3917043; rs3917038; rs3917075; rs3917033; rs3917058; rs3917034; rs3917019; rs3917020; rs3917064; rs3917042; rs3176871; rs3176863; rs3917059; rs3917018; rs1476408; rs3176877; rs3917009; rs3917062; rs3176867; rs3917036; rs3181091; rs3917053; rs3181089; rs3917032; rs3917028; rs3917070; rs3917056; rs3917060; rs3917047; rs3917072; rs3917057; rs3917011; rs3917065; rs3917074; rs34186667; rs3917051; rs3176864; rs3917068; rs3917015; rs3917049; rs3917073; rs3917052; rs3917010; rs3176859; rs3917069; rs3917071; rs3917066; rs3917014; rs3176868; rs3917055; rs3917031; rs3917063; rs34599539; rs3917008; rs1041163; rs3181092; rs1409419; rs3917024; rs3181093; rs3170794; rs3181087; rs3783598; rs3783624; rs3783595; rs3783605; rs3917022; rs3917025; rs3783601; rs3783597; rs3917027; rs3917026; rs3783599; rs3783603; rs34708918; rs17123276; rs34682069; rs41287272; rs41402047; rs3194002; rs3783620; rs12740248; rs3917048; rs34736359; rs35831577; rs36046590; rs35811606; rs34871919; rs34681548; rs10680526; rs34203893; rs3917013; rs34484900; rs35625117; rs3176872; rs35904710; rs35377403; rs35668724; rs3917050; rs3917061; rs36115922; rs34602730; rs3917046; rs35885801; rs34934334; rs3917039; rs3917045; rs3181090; rs34552536; rs3917054; rs3917035; rs3917030; rs3176865; rs35026515; rs35742683; rs34768146; rs3917044; rs3917017; rs34577442; rs34037455; rs3917029; rs3783606; rs3783600; rs3917021; rs35200787; rs17109912; rs11420952; rs1800821; rs11302130; rs3834000; rs34900848; rs10493936; rs12080503; rs12129732; rs12240047; rs12403247; rs12409568; rs12732056; rs12747073; rs1571049; rs1582090; rs1582091; rs2050471; rs2094241; rs2209628; rs34853105; rs35964031; rs35978793; rs3917078; rs4520436; rs4584412; rs6660837; rs6680254

# Macromolecular_Interacting_Partner_22_General_References:
2688898; 1699207; 1707873; 1715583; 1379595; 1707234; 1377228; 7531291; 7539925

# Macromolecular_Interacting_Partner_22_References:
11834524

# Macromolecular_Interacting_Partner_23_ID:
8035

# Macromolecular_Interacting_Partner_23_Name:
Endothelin B receptor precursor

# Macromolecular_Interacting_Partner_23_Synonyms:
ET-B; Endothelin receptor Non- selective type

# Macromolecular_Interacting_Partner_23_Gene_Name:
EDNRB

# Macromolecular_Interacting_Partner_23_Protein_Sequence:
>Endothelin B receptor precursor
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS

# Macromolecular_Interacting_Partner_23_Number_of_Residues:
442

# Macromolecular_Interacting_Partner_23_Molecular_Weight:
49644

# Macromolecular_Interacting_Partner_23_Theoretical_pI:
9.05

# Macromolecular_Interacting_Partner_23_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  peptide receptor activity, G-protein coupled
Function:  endothelin receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_23_General_Function:
Not Available

# Macromolecular_Interacting_Partner_23_Specific_Function:
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

# Macromolecular_Interacting_Partner_23_Pathway:
Not Available

# Macromolecular_Interacting_Partner_23_Reaction:
Not Available

# Macromolecular_Interacting_Partner_23_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_23_Signals:
1-26

# Macromolecular_Interacting_Partner_23_Transmembrane_Regions:
102-126
138-163
176-197
219-243
272-296
325-350
363-389

# Macromolecular_Interacting_Partner_23_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_23_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_23_GenBank_ID_Protein:
182276

# Macromolecular_Interacting_Partner_23_SwissProt_ID:
EDNRB_HUMAN (P24530)

# Macromolecular_Interacting_Partner_23_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_23_Genecard_id:
EDNRB

# Macromolecular_Interacting_Partner_23_Geneatlas_id:
EDNRB

# Macromolecular_Interacting_Partner_23_hgnc_id:
HGNC:3180

# Macromolecular_Interacting_Partner_23_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_23_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_23_Gene_Sequence:
>1329 bp
ATGCAGCCGCCTCCAAGTCTGTGCGGACGCGCCCTGGTTGCGCTGGTTCTTGCCTGCGGC
CTGTCGCGGATCTGGGGAGAGGAGAGAGGCTTCCCGCCTGACAGGGCCACTCCGCTTTTG
CAAACCGCAGAGATAATGACGCCACCCACTAAGACCTTATGGCCCAAGGGTTCCAACGCC
AGTCTGGCGCGGTCGTTGGCACCTGCGGAGGTGCCTAAAGGAGACAGGACGGCAGGATCT
CCGCCACGCACCATCTCCCCTCCCCCGTGCCAAGGACCCATCGAGATCAAGGAGACTTTC
AAATACATCAACACGGTTGTGTCCTGCCTTGTGTTCGTGCTGGGGATCATCGGGAACTCC
ACACTTCTGAGAATTATCTACAAGAACAAGTGCATGCGAAACGGTCCCAATATCTTGATC
GCCAGCTTGGCTCTGGGAGACCTGCTGCACATCGTCATTGACATCCCTATCAATGTCTAC
AAGCTGCTGGCAGAGGACTGGCCATTTGGAGCTGAGATGTGTAAGCTGGTGCCTTTCATA
CAGAAAGCCTCCGTGGGAATCACTGTGCTGAGTCTATGTGCTCTGAGTATTGACAGATAT
CGAGCTGTTGCTTCTTGGAGTAGAATTAAAGGAATTGGGGTTCCAAAATGGACAGCAGTA
GAAATTGTTTTGATTTGGGTGGTCTCTGTGGTTCTGGCTGTCCCTGAAGCCATAGGTTTT
GATATAATTACGATGGACTACAAAGGAAGTTATCTGCGAATCTGCTTGCTTCATCCCGTT
CAGAAGACAGCTTTCATGCAGTTTTACAAGACAGCAAAAGATTGGTGGCTGTTCAGTTTC
TATTTCTGCTTGCCATTGGCCATCACTGCATTTTTTTATACACTAATGACCTGTGAAATG
TTGAGAAAGAAAAGTGGCATGCAGATTGCTTTAAATGATCACCTAAAGCAGAGACGGGAA
GTGGCCAAAACCGTCTTTTGCCTGGTCCTTGTCTTTGCCCTCTGCTGGCTTCCCCTTCAC
CTCAGCAGGATTCTGAAGCTCACTCTTTATAATCAGAATGATCCCAATAGATGTGAACTT
TTGAGCTTTCTGTTGGTATTGGACTATATTGGTATCAACATGGCTTCACTGAATTCCTGC
ATTAACCCAATTGCTCTGTATTTGGTGAGCAAAAGATTCAAAAACTGCTTTAAGTCATGC
TTATGCTGCTGGTGCCAGTCATTTGAAGAAAAACAGTCCTTGGAGGAAAAGCAGTCGTGC
TTAAAGTTCAAAGCTAATGATCACGGATATGACAACTTCCGTTCCAGTAATAAATACAGC
TCATCTTGA

# Macromolecular_Interacting_Partner_23_GenBank_ID_Gene:
M74921

# Macromolecular_Interacting_Partner_23_Chromosome_Location:
Chromosome:13

# Macromolecular_Interacting_Partner_23_Locus:
13q22

# Macromolecular_Interacting_Partner_23_SNPs:
rs5352; rs1801710; rs2228271; rs5351; rs5349; rs5348; rs1537065; rs2329047; rs4884077; rs9544646; rs7333359; rs12585118; rs1537063; rs4884075; rs4885497; rs1924914; rs9544640; rs9544635; rs9574129; rs7997107; rs7332215; rs7326686; rs7333015; rs4885496; rs9318502; rs1854800; rs7330412; rs7323156; rs7317154; rs4885499; rs9544638; rs7328067; rs11618814; rs9574126; rs1924917; rs3027095; rs3759475; rs4283112; rs1924916; rs2329051; rs9565372; rs11838546; rs2070591; rs2068779; rs12720130; rs7326641; rs7324245; rs7324912; rs11149085; rs3027092; rs10507875; rs12716722; rs2329050; rs6563023; rs7333372; rs3027094; rs9544643; rs7325878; rs7358970; rs12720146; rs12720158; rs4275748; rs7319342; rs9574124; rs2181998; rs7339077; rs12720148; rs9574123; rs9544634; rs7332993; rs12720154; rs4884076; rs12720125; rs7329997; rs4885491; rs9544654; rs1537066; rs17068607; rs12720103; rs12720132; rs12720135; rs7491671; rs12720104; rs8000166; rs12720115; rs2329053; rs12720121; rs9544639; rs12720138; rs12720129; rs2329049; rs4474579; rs12720114; rs12720156; rs17068606; rs7323965; rs12720133; rs11839683; rs13378231; rs12720105; rs13378491; rs7998775; rs9544642; rs12720159; rs2876718; rs17068573; rs12720123; rs12720131; rs12720107; rs4884074; rs1951968; rs4366606; rs2329052; rs12720136; rs1924938; rs4885500; rs12720111; rs12720128; rs9544636; rs2329054; rs12720140; rs12720108; rs9544650; rs12720145; rs3759476; rs9600951; rs1537064; rs12720110; rs12720109; rs1924937; rs12720141; rs12720124; rs12720151; rs9574122; rs12720142; rs12720147; rs12720117; rs12720150; rs4242968; rs9600947; rs6563024; rs12720137; rs2329046; rs1886481; rs1886480; rs2147555; rs6563021; rs3818416; rs6563022; rs4885493; rs4885492; rs12720174; rs7990782; rs7333867; rs12720170; rs3027111; rs12720167; rs12720162; rs942612; rs12720199; rs11617203; rs3027110; rs12585038; rs7317759; rs2296281; rs9530703; rs942611; rs3027129; rs12720192; rs7982910; rs12720169; rs3027139; rs4884073; rs3027096; rs12720193; rs1924928; rs7325560; rs17068547; rs3027108; rs12720201; rs9600948; rs12720177; rs12720197; rs7333189; rs12720184; rs7318710; rs12720198; rs12720190; rs12720185; rs12720179; rs3027097; rs12720164; rs12720175; rs3027128; rs17068554; rs3027109; rs3027112; rs12720168; rs12720166; rs4435136; rs12720176; rs12720200; rs12720173; rs12720189; rs9544655; rs7335540; rs11149080; rs12720100; rs12720205; rs12720206; rs12584968; rs12720207; rs10467635; rs9544656; rs12720102; rs5345; rs5350; rs12720160; rs5347; rs3027103; rs5346; rs1050929; rs9565374; rs35546854; rs2209396; rs35299848; rs8000027; rs12720155; rs9544653; rs12720116; rs10709405; rs12868931; rs12720202; rs5804946; rs12720127; rs4476058; rs3039630; rs12720143; rs9544637; rs9530705; rs4587838; rs12720149; rs4884078; rs9530707; rs35723115; rs12583488; rs34186282; rs11436675; rs12872162; rs9544652; rs12872030; rs4884080; rs12720157; rs12427574; rs9530706; rs35338290; rs35040087; rs9544648; rs1050928; rs9544651; rs12720144; rs11841950; rs5804948; rs9544649; rs6145134; rs34546158; rs12868905; rs28645841; rs35032059; rs12720204; rs9600953; rs35767174; rs12720126; rs7338917; rs3039607; rs35499769; rs35264081; rs35604831; rs34344431; rs13378946; rs1924915; rs35014196; rs1050953; rs10570239; rs12720120; rs12868651; rs9574125; rs9565373; rs12859148; rs11840500; rs4884079; rs12720152; rs9544641; rs4315250; rs34372353; rs12720139; rs34733246; rs12720119; rs34917788; rs34847991; rs34055402; rs34739301; rs5804947; rs12720203; rs7989190; rs13378232; rs7986195; rs35844812; rs12868564; rs34835146; rs11841485; rs12720134; rs11838462; rs36126166; rs3027093; rs35743336; rs5804949; rs34053276; rs9544644; rs41288258; rs35048784; rs34484665; rs7317297; rs35162306; rs28494106; rs36111652; rs3039604; rs12100353; rs28886032; rs7989185; rs3027130; rs12720165; rs3027138; rs12720195; rs12720171; rs3027102; rs11620612; rs11617410; rs3027101; rs3027125; rs3027126; rs3027098; rs11359758; rs12720181; rs3027135; rs12720194; rs12876404; rs11841535; rs11617106; rs34407545; rs9574119; rs12720178; rs11617197; rs3027127; rs35680047; rs3027137; rs3027105; rs11388909; rs12720163; rs3027132; rs12720183; rs3027100; rs28470839; rs35249035; rs28690864; rs4553483; rs9634733; rs3027131; rs3027106; rs34576965; rs12720187; rs34601466; rs35358382; rs3027134; rs3027113; rs12720186; rs1134652; rs9544630; rs11619418; rs12720161; rs12720180; rs12720196; rs3027133; rs3027104; rs35088764; rs3027136; rs3179579; rs5804944; rs3027107; rs1801709; rs28622382; rs11620611; rs3027099; rs12720172; rs35899532; rs34914864; rs10587677; rs35332479; rs12720099; rs1924918; rs12720098; rs35151769; rs11618266; rs11840443; rs1330907; rs1335803; rs1335804; rs1924919; rs1924921; rs1924922; rs1924923; rs1924924; rs1924925; rs2876720; rs4591023; rs4885489; rs7318232; rs7333255; rs7983038; rs7994913; rs7998027; rs9544627; rs9544628; rs9544662; rs9593266; rs9600945

# Macromolecular_Interacting_Partner_23_General_References:
1710450; 1648908; 1291713; 8429023; 1713452; 8440682; 1282938; 10072757; 9284755; 9261180; 11891690; 9359036; 8001158; 8634719; 8852659; 8852660; 8630503; 9760196; 11471546; 12189494

# Macromolecular_Interacting_Partner_23_References:
10725252; 10756122; 11078344; 11094045

# Macromolecular_Interacting_Partner_24_ID:
7746

# Macromolecular_Interacting_Partner_24_Name:
Endothelin-1 receptor precursor

# Macromolecular_Interacting_Partner_24_Synonyms:
Endothelin A receptor; ET-A; hET- AR; ETA-R

# Macromolecular_Interacting_Partner_24_Gene_Name:
EDNRA

# Macromolecular_Interacting_Partner_24_Protein_Sequence:
>Endothelin1 receptor precursor
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN

# Macromolecular_Interacting_Partner_24_Number_of_Residues:
427

# Macromolecular_Interacting_Partner_24_Molecular_Weight:
48723

# Macromolecular_Interacting_Partner_24_Theoretical_pI:
8.41

# Macromolecular_Interacting_Partner_24_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  peptide receptor activity, G-protein coupled
Function:  endothelin receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_24_General_Function:
Not Available

# Macromolecular_Interacting_Partner_24_Specific_Function:
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is:ET1 > ET2 >> ET3

# Macromolecular_Interacting_Partner_24_Pathway:
Not Available

# Macromolecular_Interacting_Partner_24_Reaction:
Not Available

# Macromolecular_Interacting_Partner_24_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_24_Signals:
1-20

# Macromolecular_Interacting_Partner_24_Transmembrane_Regions:
81-102
113-132
160-181
206-229
257-278
307-328
348-372

# Macromolecular_Interacting_Partner_24_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_24_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_24_GenBank_ID_Protein:
238636

# Macromolecular_Interacting_Partner_24_SwissProt_ID:
EDNRA_HUMAN (P25101)

# Macromolecular_Interacting_Partner_24_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_24_Genecard_id:
EDNRA

# Macromolecular_Interacting_Partner_24_Geneatlas_id:
EDNRA

# Macromolecular_Interacting_Partner_24_hgnc_id:
HGNC:3179

# Macromolecular_Interacting_Partner_24_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_24_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_24_Gene_Sequence:
>1284 bp
ATGGAAACCCTTTGCCTCAGGGCATCCTTTTGGCTGGCACTGGTTGGATGTGTAATCAGT
GATAATCCTGAGAGATACAGCACAAATCTAAGCAATCATGTGGATGATTTCACCACTTTT
CGTGGCACAGAGCTCAGCTTCCTGGTTACCACTCATCAACCCACTAATTTGGTCCTACCC
AGCAATGGCTCAATGCACAACTATTGCCCACAGCAGACTAAAATTACTTCAGCTTTCAAA
TACATTAACACTGTGATATCTTGTACTATTTTCATCGTGGGAATGGTGGGGAATGCAACT
CTGCTCAGGATCATTTACCAGAACAAATGTATGAGGAATGGCCCCAACGCGCTGATAGCC
AGTCTTGCCCTTGGAGACCTTATCTATGTGGTCATTGATCTCCCTATCAATGTATTTAAG
CTGCTGGCTGGGCGCTGGCCTTTTGATCACAATGACTTTGGCGTATTTCTTTGCAAGCTG
TTCCCCTTTTTGCAGAAGTCCTCGGTGGGGATCACCGTCCTCAACCTCTGCGCTCTTAGT
GTTGACAGGTACAGAGCAGTTGCCTCCTGGAGTCGTGTTCAGGGAATTGGGATTCCTTTG
GTAACTGCCATTGAAATTGTCTCCATCTGGATCCTGTCCTTTATCCTGGCCATTCCTGAA
GCGATTGGCTTCGTCATGGTACCCTTTGAATATAGGGGTGAACAGCATAAAACCTGTATG
CTCAATGCCACATCAAAATTCATGGAGTTCTACCAAGATGTAAAGGACTGGTGGCTCTTC
GGGTTCTATTTCTGTATGCCCTTGGTGTGCACTGCGATCTTCTACACCCTCATGACTTGT
GAGATGTTGAACAGAAGGAATGGCAGCTTGAGAATTGCCCTCAGTGAACATCTTAAGCAG
CGTCGAGAAGTGGCAAAAACAGTTTTCTGCTTGGTTGTAATTTTTGCTCTTTGCTGGTTC
CCTCTTCATTTAAGCCGTATATTGAAGAAAACTGTGTATAACGAGATGGACAAGAACCGA
TGTGAATTACTTAGTTTCTTACTGCTCATGGATTACATCGGTATTAACTTGGCAACCATG
AATTCATGTATAAACCCCATAGCTCTGTATTTTGTGAGCAAGAAATTTAAAAATTGTTTC
CAGTCATGCCTCTGCTGCTGCTGTTACCAGTCCAAAAGTCTGATGACCTCGGTCCCCATG
AACGGAACAAGCATCCAGTGGAAGAACCACGATCAAAACAACCACAACACAGACCGGAGC
AGCCATAAGGACAGCATGAACTGA

# Macromolecular_Interacting_Partner_24_GenBank_ID_Gene:
S63938

# Macromolecular_Interacting_Partner_24_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_24_Locus:
4q31.23

# Macromolecular_Interacting_Partner_24_SNPs:
rs5333; rs5334; rs2292764; rs5335; rs984457; rs5342; rs9308218; rs1356349; rs984458; rs5341; rs1801708; rs4835083; rs5340; rs10305851; rs10305862; rs5344; rs6855875; rs10305848; rs5336; rs5339; rs10305865; rs4835084; rs5862805; rs5343; rs10305937; rs10305866; rs10305859; rs10305849; rs5337; rs5338; rs10305935; rs11267091; rs10305852; rs10305931; rs10305938; rs10305936; rs10305932; rs10305853; rs10305860; rs2884340; rs1400556; rs1517135; rs2884337; rs952402; rs1878404; rs1996373; rs2048894; rs1996374; rs9308221; rs10029799; rs9884319; rs7655892; rs10008744; rs3814415; rs6840375; rs13143677; rs6812093; rs6840756; rs7655670; rs6827096; rs7674137; rs11933442; rs1568136; rs6841799; rs6537489; rs1517134; rs9308220; rs9307838; rs6822565; rs908581; rs7690347; rs2292765; rs9999853; rs6854578; rs6823537; rs10028507; rs7663891; rs7666105; rs702757; rs10003447; rs7677315; rs9308219; rs10305929; rs11939191; rs10305884; rs17612742; rs11946376; rs2357924; rs6855898; rs3942348; rs17474816; rs10305912; rs10010949; rs6848108; rs9997823; rs10011966; rs10305889; rs10305925; rs16998721; rs6537487; rs10305928; rs11940834; rs10031628; rs10305895; rs4639051; rs11946826; rs17023373; rs10305917; rs10024834; rs10305883; rs10305921; rs4835410; rs11942855; rs17023371; rs7684766; rs17474823; rs3756022; rs6821368; rs4835412; rs10028666; rs10011035; rs11938394; rs10305880; rs6843446; rs7681275; rs10305926; rs4835086; rs10305927; rs6841473; rs6831737; rs10305920; rs10305875; rs9307837; rs17675063; rs10305863; rs10305886; rs10305899; rs10305892; rs10305922; rs17023360; rs11935436; rs10020557; rs10305909; rs1400554; rs10305914; rs10305888; rs17023396; rs10305923; rs2884339; rs10305907; rs10305915; rs10305871; rs10305881; rs11937200; rs11938973; rs10305876; rs17023363; rs10305906; rs4591581; rs10305913; rs11942620; rs10305898; rs10305919; rs10017079; rs10305908; rs13306320; rs10305869; rs10305916; rs10305879; rs10305910; rs11830; rs10305896; rs10305885; rs11936340; rs10305918; rs11934092; rs10305894; rs2884341; rs4563479; rs10305870; rs10011234; rs13435440; rs6842241; rs10305840; rs1800786; rs6841581; rs10305845; rs10305838; rs10305844; rs10305842; rs10305839; rs10305846; rs17852056; rs17856671; rs17856670; rs10305868; rs10305867; rs17852057; rs13306317; rs11724088; rs10305861; rs11552087; rs35309925; rs35184992; rs10305930; rs10305856; rs3190169; rs34136788; rs10305854; rs35542356; rs35063997; rs13306318; rs10305933; rs33954623; rs3216163; rs10305857; rs10305858; rs36124688; rs1049963; rs10305855; rs11930745; rs35678177; rs10305934; rs34375765; rs36077037; rs13306316; rs2292766; rs3068757; rs9993718; rs34466950; rs11726398; rs10305903; rs35088870; rs13125865; rs35757953; rs13121996; rs10305905; rs1517133; rs34531381; rs4455398; rs35630078; rs34246155; rs35826351; rs10305890; rs34533330; rs33912823; rs34015008; rs10570878; rs17023496; rs4419459; rs13121537; rs34890988; rs10692988; rs10305882; rs10551607; rs4835411; rs34079253; rs10305878; rs10305902; rs34962702; rs10305873; rs35796687; rs7660300; rs28839485; rs33985171; rs34658974; rs35034877; rs13136385; rs13121745; rs33954106; rs10305900; rs13113405; rs11940520; rs34965226; rs7437031; rs11337911; rs33958974; rs34229972; rs2357925; rs34519684; rs10305874; rs17023427; rs34270975; rs36207078; rs35961327; rs10305904; rs36023655; rs10546909; rs10024734; rs1400555; rs10305891; rs35374177; rs35106938; rs35299479; rs6818686; rs4321614; rs35151309; rs33946964; rs10305924; rs10305901; rs10305864; rs28477369; rs34887339; rs35080290; rs10012917; rs36064870; rs11464046; rs10305911; rs11732422; rs34635238; rs10305897; rs11321422; rs11405111; rs7439670; rs34291358; rs34276058; rs28551143; rs11330586; rs2229305; rs13107867; rs35774514; rs10019230; rs5862803; rs11286891; rs35139018; rs34322422; rs28572568; rs35495016; rs10003944; rs34450591; rs35461850; rs13434817; rs4456941; rs9884495; rs2357923; rs4590003; rs2884338; rs36041517; rs13142627; rs10608985; rs34437454; rs35822305; rs10305877; rs35452559; rs35932664; rs10642617; rs10305893; rs13306319; rs10305887; rs11424571; rs10305847; rs10305841; rs10305843; rs35891036; rs35349287; rs34300379; rs10028838; rs10305940; rs10305942; rs10305943; rs11734418; rs11737131; rs11942203; rs11942234; rs12650382; rs1400557; rs1568137; rs1878406; rs4333164; rs6537483; rs6537484; rs6537485; rs6811707; rs6819740; rs6823732; rs6833588; rs7657903; rs7673178; rs7684691; rs7684717; rs7684882; rs7685896; rs7685925; rs7686338; rs9307839; rs9307840; rs9884563; rs9991584

# Macromolecular_Interacting_Partner_24_General_References:
1719979; 1659806; 1652463; 1291713; 8440682; 1326535; 1415318; 8611157; 8427579; 9284755; 11262386

# Macromolecular_Interacting_Partner_24_References:
10523363

# Macromolecular_Interacting_Partner_25_ID:
8159

# Macromolecular_Interacting_Partner_25_Name:
5-hydroxytryptamine 2A receptor

# Macromolecular_Interacting_Partner_25_Synonyms:
5-HT-2A; Serotonin receptor 2A; 5- HT-2

# Macromolecular_Interacting_Partner_25_Gene_Name:
HTR2A

# Macromolecular_Interacting_Partner_25_Protein_Sequence:
>5hydroxytryptamine 2A receptor
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV

# Macromolecular_Interacting_Partner_25_Number_of_Residues:
471

# Macromolecular_Interacting_Partner_25_Molecular_Weight:
52604

# Macromolecular_Interacting_Partner_25_Theoretical_pI:
7.72

# Macromolecular_Interacting_Partner_25_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_25_General_Function:
Not Available

# Macromolecular_Interacting_Partner_25_Specific_Function:
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production

# Macromolecular_Interacting_Partner_25_Pathway:
Not Available

# Macromolecular_Interacting_Partner_25_Reaction:
Not Available

# Macromolecular_Interacting_Partner_25_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_25_Signals:
None

# Macromolecular_Interacting_Partner_25_Transmembrane_Regions:
76-99
111-132
148-171
192-215
234-254
325-346
363-384

# Macromolecular_Interacting_Partner_25_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_25_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_25_GenBank_ID_Protein:
36431

# Macromolecular_Interacting_Partner_25_SwissProt_ID:
5HT2A_HUMAN (P28223)

# Macromolecular_Interacting_Partner_25_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_25_Genecard_id:
HTR2A

# Macromolecular_Interacting_Partner_25_Geneatlas_id:
HTR2A

# Macromolecular_Interacting_Partner_25_hgnc_id:
HGNC:5293

# Macromolecular_Interacting_Partner_25_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_25_Subcellular_Location:
Cell membrane; multi-pass membrane protein. Note=Localizes to the post-synaptic thickening of axo-dendritic synapses (By similarity)

# Macromolecular_Interacting_Partner_25_Gene_Sequence:
>1416 bp
ATGGATATTCTTTGTGAAGAAAATACTTCTTTGAGCTCAACTACGAACTCCCTAATGCAA
TTAAATGATGACACCAGGCTCTACAGTAATGACTTTAACTCTGGAGAAGCTAACACTTCT
GATGCATTTAACTGGACAGTCGACTCTGAAAATCGAACCAACCTTTCCTGTGAAGGGTGC
CTCTCACCGTCGTGTCTCTCCTTACTTCATCTCCAGGAAAAAAACTGGTCTGCTTTACTG
ACAGCCGTAGTGATTATTCTAACTATTGCTGGAAACATACTCGTCATCATGGCAGTGTCC
CTAGAGAAAAAGCTGCAGAATGCCACCAACTATTTCCTGATGTCACTTGCCATAGCTGAT
ATGCTGCTGGGTTTCCTTGTCATGCCCGTGTCCATGTTAACCATCCTGTATGGGTACCGG
TGGCCTCTGCCGAGCAAGCTTTGTGCAGTCTGGATTTACCTGGACGTGCTCTTCTCCACG
GCCTCCATCATGCACCTCTGCGCCATCTCGCTGGACCGCTACGTCGCCATCCAGAATCCC
ATCCACCACAGCCGCTTCAACTCCAGAACTAAGGCATTTCTGAAAATCATTGCTGTTTGG
ACCATATCAGTAGGTATATCCATGCCAATACCAGTCTTTGGGCTACAGGACGATTCGAAG
GTCTTTAAGGAGGGGAGTTGCTTACTCGCCGATGATAACTTTGTCCTGATCGGCTCTTTT
GTGTCATTTTTCATTCCCTTAACCATCATGGTGATCACCTACTTTCTAACTATCAAGTCA
CTCCAGAAAGAAGCTACTTTGTGTGTAAGTGATCTTGGCACACGGGCCAAATTAGCTTCT
TTCAGCTTCCTCCCTCAGAGTTCTTTGTCTTCAGAAAAGCTCTTCCAGCGGTCGATCCAT
AGGGAGCCAGGGTCCTACACAGGCAGGAGGACTATGCAGTCCATCAGCAATGAGCAAAAG
GCATGCAAGGTGCTGGGCATCGTCTTCTTCCTGTTTGTGGTGATGTGGTGCCCTTTCTTC
ATCACAAACATCATGGCCGTCATCTGCAAAGAGTCCTGCAATGAGGATGTCATTGGGGCC
CTGCTCAATGTGTTTGTTTGGATCGGTTATCTCTCTTCAGCAGTCAACCCACTAGTCTAC
ACACTGTTCAACAAGACCTATAGGTCAGCCTTTTCACGGTATATTCAGTGTCAGTACAAG
GAAAACAAAAAACCATTGCAGTTAATTTTAGTGAACACAATACCGGCTTTGGCCTACAAG
TCTAGCCAACTTCAAATGGGACAAAAAAAGAATTCAAAGCAAGATGCCAAGACAACAGAT
AATGACTGCTCAATGGTTGCTCTAGGAAAGCAGCATTCTGAAGAGGCTTCTAAAGACAAT
AGCGACGGAGTGAATGAAAAGGTGAGCTGTGTGTGA

# Macromolecular_Interacting_Partner_25_GenBank_ID_Gene:
X57830

# Macromolecular_Interacting_Partner_25_Chromosome_Location:
Chromosome:13

# Macromolecular_Interacting_Partner_25_Locus:
13q14-q21

# Macromolecular_Interacting_Partner_25_SNPs:
rs1805055; rs6304; rs6308; rs6314; rs6313; rs6305; rs35480504; rs3803189; rs3125; rs17069218; rs2296973; rs1923888; rs1745837; rs643627; rs2770295; rs1002513; rs1923882; rs1923884; rs1928038; rs977003; rs1928040; rs633737; rs2770298; rs1885884; rs1923887; rs2760351; rs4942578; rs9534506; rs1928042; rs4941574; rs6561334; rs1033847; rs985934; rs9567739; rs4942587; rs2070036; rs9534511; rs2070039; rs9534493; rs9316232; rs927544; rs6561336; rs4941571; rs594242; rs9567737; rs985933; rs9534507; rs582385; rs659734; rs972979; rs4941573; rs7322347; rs582854; rs7324343; rs6561335; rs2274639; rs731779; rs9567735; rs9534509; rs2770300; rs4942582; rs17069089; rs2025296; rs2246127; rs9526238; rs1928041; rs11841433; rs622337; rs9534505; rs4941570; rs9316235; rs2070040; rs7330636; rs1328684; rs12584920; rs9526240; rs1923885; rs666693; rs2770296; rs4942583; rs7984966; rs2070037; rs9562686; rs655888; rs6561332; rs655854; rs2770302; rs9567746; rs1328683; rs7330461; rs9526246; rs1923886; rs17288723; rs2770293; rs9316233; rs2296972; rs1928039; rs9526245; rs2770304; rs2770297; rs7994746; rs1328674; rs632903; rs1410657; rs3742279; rs2224721; rs2770294; rs621494; rs912127; rs9534495; rs17359763; rs12876614; rs2760346; rs7322422; rs9567744; rs2770299; rs9534502; rs9526241; rs7332753; rs17287961; rs9526239; rs9567743; rs3945573; rs2760344; rs2760349; rs658101; rs17068986; rs7322420; rs7326071; rs7986766; rs9562687; rs731778; rs9316236; rs689099; rs677702; rs11617142; rs2760345; rs4942584; rs17360184; rs2016711; rs2760350; rs619549; rs1885882; rs9567747; rs1328677; rs7981633; rs2770292; rs1328675; rs17069020; rs3742278; rs7328886; rs7997012; rs4942585; rs2760348; rs9534496; rs1928043; rs7323792; rs9562689; rs7338257; rs9534503; rs17069035; rs9534508; rs9567745; rs7330368; rs9567736; rs4090088; rs9562685; rs17069005; rs9534510; rs9316234; rs2070035; rs9670454; rs9534504; rs9534501; rs9562688; rs2760347; rs7323079; rs7985321; rs1475196; rs1328685; rs6312; rs7324218; rs6310; rs6316; rs6311; rs7325168; rs17289304; rs7324017; rs7323441; rs7325200; rs7997977; rs7996679; rs7325801; rs7323693; rs6315; rs7324942; rs6306; rs6309; rs6317; rs9595552; rs2230948; rs6307; rs1058576; rs35224115; rs1058573; rs35942462; rs34073547; rs28461499; rs34600609; rs35222525; rs11619524; rs9562684; rs34067369; rs34546983; rs34735457; rs34191502; rs35044667; rs5803378; rs34023544; rs34389615; rs1923883; rs11444567; rs1885883; rs34156927; rs35600514; rs7317640; rs4942586; rs34265171; rs28439202; rs9567748; rs36032976; rs7322128; rs34450267; rs35735410; rs41306666; rs4942579; rs5803377; rs2770301; rs34116107; rs9534497; rs34758371; rs9567734; rs2760340; rs2146672; rs4942580; rs11148017; rs2405864; rs9567742; rs2183056; rs35774769; rs1923889; rs2770303; rs9526237; rs35990864; rs4941572; rs35157208; rs9567740; rs660358; rs2760339; rs9567738; rs33974073; rs2760343; rs11394720; rs34188313; rs2760342; rs7491120; rs35031636; rs7490923; rs17069045; rs35265991; rs2405863; rs11381663; rs10666389; rs35136640; rs12862862; rs34420017; rs10675250; rs1328676; rs688590; rs626318; rs4536360; rs10562734; rs9595553; rs35906144; rs10648117; rs34493167; rs2070038; rs5803379; rs41284193; rs2760341; rs7992607; rs35166479; rs35805696; rs33913126; rs35656598; rs1125644; rs13306426; rs36212791; rs1125643; rs36212451; rs36212784; rs36212792; rs35865007; rs36212789; rs36213156; rs1048952; rs34720476; rs10507544; rs12017281; rs12863574; rs17069137; rs17289394; rs2149433; rs2149434; rs4142900; rs4286023; rs4387507; rs4389056; rs4389057; rs4389058; rs4575433; rs4941575; rs4942588; rs6561333; rs731244; rs731245; rs732821; rs7328833; rs7329640; rs7330190; rs7330205; rs7333412; rs7490304; rs9534490; rs9534491; rs9534512; rs9534513; rs9534514; rs9534515; rs9567731; rs9567732; rs9567733; rs9590997; rs9595546; rs9595549; rs9595550; rs9595551

# Macromolecular_Interacting_Partner_25_General_References:
1722404; 1323014; 8035173; 1330647; 11150294; 8655141; 10581480; 10391209

# Macromolecular_Interacting_Partner_25_References:
16014306

# Macromolecular_Interacting_Partner_26_ID:
7872

# Macromolecular_Interacting_Partner_26_Name:
5-hydroxytryptamine 2B receptor

# Macromolecular_Interacting_Partner_26_Synonyms:
5-HT-2B; Serotonin receptor 2B

# Macromolecular_Interacting_Partner_26_Gene_Name:
HTR2B

# Macromolecular_Interacting_Partner_26_Protein_Sequence:
>5hydroxytryptamine 2B receptor
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
V

# Macromolecular_Interacting_Partner_26_Number_of_Residues:
481

# Macromolecular_Interacting_Partner_26_Molecular_Weight:
54299

# Macromolecular_Interacting_Partner_26_Theoretical_pI:
9.47

# Macromolecular_Interacting_Partner_26_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_26_General_Function:
Not Available

# Macromolecular_Interacting_Partner_26_Specific_Function:
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

# Macromolecular_Interacting_Partner_26_Pathway:
Not Available

# Macromolecular_Interacting_Partner_26_Reaction:
Not Available

# Macromolecular_Interacting_Partner_26_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_26_Signals:
None

# Macromolecular_Interacting_Partner_26_Transmembrane_Regions:
57-79
92-113
130-151
172-192
217-239
325-345
361-383

# Macromolecular_Interacting_Partner_26_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_26_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_26_GenBank_ID_Protein:
475198

# Macromolecular_Interacting_Partner_26_SwissProt_ID:
5HT2B_HUMAN (P41595)

# Macromolecular_Interacting_Partner_26_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_26_Genecard_id:
HTR2B

# Macromolecular_Interacting_Partner_26_Geneatlas_id:
HTR2B

# Macromolecular_Interacting_Partner_26_hgnc_id:
HGNC:5294

# Macromolecular_Interacting_Partner_26_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_26_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_26_Gene_Sequence:
>1446 bp
ATGGCTCTCTCTTACAGAGTGTCTGAACTTCAAAGCACAATTCCTGAGCACATTTTGCAG
AGCACCTTTGTTCACGTTATCTCTTCTAACTGGTCTGGATTACAGACAGAATCAATACCA
GAGGAAATGAAACAGATTGTTGAGGAACAGGGAAATAAACTGCACTGGGCAGCTCTTCTG
ATACTCATGGTGATAATACCCACAATTGGTGGAAATACCCTTGTTATTCTGGCTGTTTCA
CTGGAGAAGAAGCTGCAGTATGCTACTAATTACTTTCTAATGTCCTTGGCGGTGGCTGAT
TTGCTGGTTGGATTGTTTGTGATGCCAATTGCCCTCTTGACAATAATGTTTGAGGCTATG
TGGCCCCTCCCACTTGTTCTATGTCCTGCCTGGTTATTTCTTGACGTTCTCTTTTCAACC
GCATCCATCATGCATCTCTGTGCCATTTCAGTGGATCGTTACATAGCCATCAAAAAGCCA
ATCCAGGCCAATCAATATAACTCACGGGCTACAGCATTCATCAAGATTACAGTGGTGTGG
TTAATTTCAATAGGCATTGCCATTCCAGTCCCTATTAAAGGGATAGAGACTGATGTGGAC
AACCCAAACAATATCACTTGTGTGCTGACAAAGGAACGTTTTGGCGATTTCATGCTCTTT
GGCTCACTGGCTGCCTTCTTCACACCTCTTGCAATTATGATTGTCACCTACTTTCTCACT
ATCCATGCTTTACAGAAGAAGGCTTACTTAGTCAAAAACAAGCCACCTCAACGCCTAACA
TGGTTGACTGTGTCTACAGTTTTCCAAAGGGATGAAACACCTTGCTCGTCACCGGAAAAG
GTGGCAATGCTGGATGGTTCTCGAAAGGACAAGGCTCTGCCCAACTCAGGTGATGAAACA
CTTATGCGAAGAACATCCACAATTGGGAAAAAGTCAGTGCAGACCATTTCCAACGAACAG
AGAGCCTCAAAGGTCCTAGGGATTGTGTTTTTCCTCTTTTTGCTTATGTGGTGTCCCTTC
TTTATTACAAATATAACTTTAGTTTTATGTGATTCCTGTAACCAAACTACTCTCCAAATG
CTCCTGGAGATATTTGTGTGGATAGGCTATGTTTCCTCAGGAGTGAATCCTTTGGTCTAC
ACCCTCTTCAATAAGACATTTCGGGATGCATTTGGCCGATATATCACCTGCAATTACCGG
GCCACAAAGTCAGTAAAAACTCTCAGAAAACGCTCCAGTAAGATCTACTTCCGGAATCCA
ATGGCAGAGAACTCTAAGTTTTTCAAGAAACATGGAATTCGAAATGGGATTAACCCTGCC
ATGTACCAGAGTCCAATGAGGCTCCGAAGTTCAACCATTCAGTCTTCATCAATCATTCTA
CTAGATACGCTTCTCCTCACTGAAAATGAAGGTGACAAAACTGAAGAGCAAGTTAGTTAT
GTATAG

# Macromolecular_Interacting_Partner_26_GenBank_ID_Gene:
X77307

# Macromolecular_Interacting_Partner_26_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_26_Locus:
2q36.3-q37.1

# Macromolecular_Interacting_Partner_26_SNPs:
Not Available

# Macromolecular_Interacting_Partner_26_General_References:
8143856; 7926008; 8078486; 10722792; 11150294

# Macromolecular_Interacting_Partner_26_References:
8627522

# Macromolecular_Interacting_Partner_27_ID:
8202

# Macromolecular_Interacting_Partner_27_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_27_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_27_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_27_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_27_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_27_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_27_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_27_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_27_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_27_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_27_Pathway:
Not Available

# Macromolecular_Interacting_Partner_27_Reaction:
Not Available

# Macromolecular_Interacting_Partner_27_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_27_Signals:
None

# Macromolecular_Interacting_Partner_27_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_27_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_27_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_27_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_27_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_27_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_27_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_27_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_27_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_27_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_27_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_27_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_27_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_27_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_27_Locus:
10q22

# Macromolecular_Interacting_Partner_27_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_27_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_27_References:
11208696; 12623949

End of HMDB00016

Beginning of HMDB00017
# Accession_No:
HMDB00017

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-24 15:59:56

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
4-Pyridoxic acid

# Description:
The catabolic product of VITAMIN B6 (pyridoxine, pyridoxal and pyradoxamine) which is excreted in the urine. Urine levels of 4-pyridoxic acid are lower in females than in males and will be reduced in persons with riboflavin deficiency. 

# Synonyms:
2-Methyl-3-hydroxy-4-carboxy-5-hydroxymethylpyridine; 3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxylate; 3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxylic acid; 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinate; 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinic acid; 3-Hydroxy-5-hydroxymethyl-2-methyl-isonicotinsaeure; 3-hydroxy-5-(hydroxymethyl)-2-methyl-Isonicotinate; 3-hydroxy-5-(hydroxymethyl)-2-methyl-Isonicotinic acid; 3-hydroxy-5-hydroxymethyl-2-methyl-isonicotinate; 3-hydroxy-5-hydroxymethyl-2-methyl-isonicotinic acid; 4-Pyridoxate; 4-Pyridoxinate; 4-Pyridoxinecarboxylate; 4-Pyridoxinecarboxylic acid; 4-Pyridoxinic acid; 4-Pyridoxinsaeure; 4-Pyridoxylate; 4-Pyridoxylic acid

# Chemical_IUPAC_Name:
3-hydroxy-5-(hydroxymethyl)-2-methyl-pyridine-4-carboxylic acid

# Chemical_Formula:
C8H9NO4

# Chemical_Structure:
tbl_chemical:::HMDB00017_ZOOM.png:::119283131002915442

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00017_THUMB.png:::11928313080691496

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Vitamins

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary alcohol; phenol or hydroxyhetarene; carboxylic acid; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
183.05316

# Molecular_Weight_Avg:
183.16136

# Smiles_String_isomeric:
CC1=NC=C(CO)C(C(O)=O)=C1O

# Smiles_String_canonical:
CC1=NC=C(CO)C(C(O)=O)=C1O

# KEGG_Compound_ID:
C00847

# BioCyc_ID:
CPD-1112

# PubChem_CID:
6723

# PubChem_SID:
149703; 96540; 8154358; 8144151; 7591946; 3884996; 4104; 10428690

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
36190

# Wikipedia_ID:
Not Available

# METLIN_ID:
239

# Ref_ID:
12001008; 8279138; 15447904; 15975484; 16054880; 1742549; 16277678; 15450810; 12638029; 15976101; 12368406

# ChEBI_ID:
17405

# CAS_Registry_Number:
82-82-6

# InChI:
InChI=1/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)

# Synthesis_Reference:
Huff, J.W. et al., J. Biol. Chem., 1944, 155, 345-355; Japan. Pat., 1992, 04 95 074 CA, 117, 90051d

# Melting_Point:
247-248 oC

# Melting_Point_predicted:
110.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
53.0 mg/mL [MEYLAN,WM et al. (1996)]; 8.72 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-0.07 [Predicted by ALOGPS]; 0.1 [Predicted by PubChem via XLOGP]; -0.07 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::4-Pyridoxic_acid.mol:::1132723801437701829

# SDF_File_[Text]:
tbl_chemical:::HMDB00017.sdf:::119283130420487761

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00017.pdb:::119283130639547582

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::00017_Pyridoxic_acid.zip:::118236134393642128

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050126_P00_10_IS_assigned.png:::118236134395715221

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050126_P00_10_IS_2DHSQC_1419.png:::116248599192417548

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050126_P00_10_IS_2DHSQC_1419.zip:::116248599196244168

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::Pyridoxic acid(HMDB00017).png:::116248599217446161

# Predicted_H_NMR_Spectrum:
tbl_chemical:::4-Pyridoxic acid.gif:::1132732098968680247

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00017_peaks.txt:::1156309487243422876

# Predicted_C_NMR_Spectrum:
tbl_chemical:::4-Pyridoxic acid_C.gif:::1132737657587448565

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00017_peaks.txt:::1156310679242715956

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; Extracellular

# Tissue_Location:
Bladder; Erythrocyte; Kidney; Liver

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	12.52 +/- 6.53	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	12001008
Urine	> 3.0	umol/L	Children:1-13_yrs_old	Both	Normal	12368406
Blood	0.040 +/- 0.007	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Bladder Cancer; Vitamin B6 Deficiency

# Pathway_Names:
Valine, leucine and isoleucine degradation;Vitamin B6 metabolism;Nicotinate and nicotinamide metabolism;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
valine,leucine,and_isoleucine_degradation.jpg;;Nicotinamide_synthesis_(NADH).jpg;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00280;map00750;map00760;map00280;map00280

# Pathway_Graphs:
valine,leucine,and_isoleucine_degradation_Graph.jpg;;Nicotinamide_synthesis_(NADH)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
valine,leucine,and_isoleucine_degradation.xml;;Nicotinamide_synthesis_(NADH).xml;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5358

# Metabolic_Enzyme_1_Name:
Aldehyde oxidase

# Metabolic_Enzyme_1_Synonyms:
Not Available

# Metabolic_Enzyme_1_Gene_Name:
AOX1

# Metabolic_Enzyme_1_Protein_Sequence:
>Aldehyde oxidase
MDRASELLFYVNGRKVIEKNVDPETMLLPYLRKKLRLTGTPYGCGGGGCGACTVMISRYN
PITKRIRHHPANACLIPICSLYGAAVTTVEGIGSTHTRIHPVQERIAKCHGTQCGFCTPG
MVMSIYPLLRNHPEPTLDQLTDALGGNLCRCHGYRPIIDACKTFCKTSGCCQSKENGVCC
LDQGINGLPEFEEGSKTSPKLFAEEEFLPLDPTQELIFPPELMIMADKQSQRTRVFGSER
MMWFSPVTLKDLLEFKFKYPQAPVIMGNTSVGPEVKFKGVFHPGYNSPDRIEEPECCKPC
IYGLTLGAGLSLAQVKDILADVVQKLPEEKTQMYHALLKHLGTLAGSQIRNMASLGGHII
SRHPDSDLNPILAVGNCTLNLLSKEGKRQIPLNEQFLSKCPNADLKPQEILVSVNIPISR
KWEFVSAFRQAQRQENALAIVNSGMRVFFGEGDGIIRELCISYGGVGPATICAKNSCQKL
IGRHWNEQMLDIACRLILNEVSLLGSAPGGKVEFKRTLIISFLFKFYLEVSQILKKMDPV
HYPSLADKYESALEDLHSKHHCSTLKYQNIGPKQHPEDPIGHPIMHLSGVKHATGEAIYC
DDMPLVDQELFLTFVTSSRAHAKIVSIDLSEALSMPGVVDIMTAEHLSDVNSFCFFTEAE
KFLATDKVFCVGQLVCAVLADSEVQAKRAAKRVKIVYQDLEPLILTIEESIQHNSSFKPE
RKLEYGNVDEAFKVVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDQEMDVYVSTQFPKY
IQDIVASTLKLPANKVMCHVRRVGGAFGGKVLKTGIIAAVTAFAANKHGRAVRCVLERGE
DMLITGGRHPYLGKYKAGFMNDGRILALDMEHYSNAGASLDESLFVIEMGLLKMDNAYKF
PNLRCRGWACRTNLPSNTAFRGFGFPQAVLITESCITEVAAKCGLSPEKVRIINMYKEID
QTPYKQEINAKNLIQCWRECMAMSSYSLRKVAVEKFNAENYWKKKGLAMVPLKFPVGLAS
RAAGQAAALVHIYLDGSVLVTHGGIEMGQGVHTKMIQVVSRELRMPMSNVHLRGTSTETV
PNANISGGSVVADLNGLAVKDACQTLLKRLEPIISKNPKGTWKDWAQTAFDESINLSAVG
YFRGYESDMNWEKGEGQPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGCSINPAID
IGQIEGAFIQGMGLYTIEELNYSPQGILHTRGPDQYKIPAICDMPTELHIALLPPSQNSN
TLYSSKGLGESGVFLGCSVFFAIHDAVSAARQERGLHGPLTLNSPLTPEKIRMACEDKFT
KMIPRDEPGSYVPWNVPI

# Metabolic_Enzyme_1_Number_of_Residues:
1338

# Metabolic_Enzyme_1_Molecular_Weight:
147933

# Metabolic_Enzyme_1_Theoretical_pI:
7.11

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  transporter activity
Function:  electron transporter activity
Function:  binding
Function:  ion binding
Function:  metal ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
An aldehyde + H(2)O + O(2) = a carboxylic acid + H(2)O(2)

# Metabolic_Enzyme_1_Pathway:
map00280  Valine, leucine and isoleucine degradation;
 map00350  Tyrosine metabolism;
 map00380  Tryptophan metabolism;
 map00750  Vitamin B6 metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_1_Reaction:
an aldehyde + H2O + O2 = a carboxylic acid + H2O2

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01315:Ald_Xan_dh_C;
PF02738:Ald_Xan_dh_C2;
PF03450:CO_deh_flav_C;
PF00941:FAD_binding_5;
PF00111:Fer2;
PF01799:Fer2_2

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.2.3.1

# Metabolic_Enzyme_1_GenBank_ID_Protein:
438656

# Metabolic_Enzyme_1_SwissProt_ID:
ADO_HUMAN (Q06278)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
AOX1

# Metabolic_Enzyme_1_Geneatlas_id:
AOX1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:553

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>4017 bp
ATGGACCGGGCGTCCGAGCTGCTCTTCTACGTGAACGGCCGCAAGGTGATAGAAAAAAAT
GTCGATCCTGAAACAATGCTGTTGCCTTATTTGAGGAAGAAGCTTCGACTCACAGGAACT
CCGTATGGCTGTGGAGGAGGAGGCTGTGGTGCTTGTACAGTGATGATATCACGATACAAC
CCCATCACCAAGAGGATAAGGCATCACCCAGCCAATGCCTGTCTGATTCCCATCTGTTCT
CTGTATGGTGCTGCCGTCACCACAGTAGAAGGCATAGGAAGCACCCACACCAGAATTCAT
CCTGTTCAGGAGAGGATTGCCAAGTGTCATGGCACCCAGTGTGGCTTCTGCACACCTGGG
ATGGTGATGTCCATCTACCCCCTGCTCAGGAACCACCCAGAGCCCACTCTGGATCAGTTA
ACTGATGCCCTTGGTGGTAACCTGTGCCGTTGCCATGGATACAGGCCCATAATTGATGCA
TGCAAGACTTTCTGTAAAACTTCGGGCTGCTGTCAAAGTAAAGAAAATGGGGTTTGCTGT
TTGGATCAAGGAATCAATGGATTGCCAGAATTTGAGGAAGGAAGTAAGACAAGTCCAAAA
CTCTTCGCAGAAGAGGAGTTTCTGCCATTGGATCCAACCCAGGAACTGATATTTCCTCCT
GAGCTAATGATAATGGCTGATAAACAGTCGCAAAGGACCAGGGTGTTTGGCAGTGAGAGA
ATGATGTGGTTTTCCCCCGTGACCCTGAAGGACCTGCTGGAATTTAAATTCAAGTATCCC
CAGGCTCCTGTTATCATGGGAAACACCTCTGTGGGGCCTGAAGTGAAATTTAAAGGCGTC
TTTCACCCAGGTTATAATTCTCCTGATAGAATTGAAGAACCTGAGTGTTGTAAACCATGC
ATATATGGACTCACCCTTGGTGCTGGTCTCAGCCTAGCCCAGGTGAAGGACATTTTGGCT
GATGTAGTCCAGAAGCTTCCAGAGGAGAAGACACAGATGTACCATGCTCTCCTGAAGCAT
TTGGGAACTCTGGCTGGGTCCCAGATCAGGAACATGGCTTCTTTAGGGGGACACATCATT
AGCAGGCATCCAGATTCAGATCTGAATCCCATCCTGGCTGTGGGTAACTGTACCCTCAAC
TTGCTATCAAAAGAAGGAAAACGACAGATTCCTTTAAATGAGCAATTCCTCAGCAAGTGC
CCTAATGCAGATCTTAAGCCTCAAGAAATCTTGGTCTCAGTGAACATCCCCATCTCAAGG
AAGTGGGAATTTGTGTCAGCCTTCCGACAAGCCCAGCGACAGGAGAATGCGCTAGCGATA
GTCAATTCAGGAATGAGAGTCTTTTTTGGAGAAGGGGATGGCATTATTAGAGAGTTATGC
ATCTCATATGGAGGCGTTGGTCCAGCCACCATCTGTGCCAAGAATTCCTGCCAGAAACTC
ATTGGAAGGCACTGGAACGAACAGATGCTGGATATAGCCTGCAGGCTTATTCTGAATGAA
GTCTCCCTTTTGGGCTCGGCGCCAGGTGGGAAAGTGGAGTTCAAGAGGACTCTCATCATC
AGCTTCCTCTTCAAGTTCTACCTGGAAGTGTCACAGATTTTGAAAAAGATGGATCCAGTT
CACTATCCTAGCCTTGCAGACAAGTATGAAAGTGCTTTAGAAGATCTTCATTCCAAACAT
CACTGCAGTACATTAAAGTACCAGAATATAGGCCCAAAGCAGCATCCTGAAGACCCAATT
GGCCACCCCATCATGCATCTGTCTGGTGTGAAGCATGCCACGGGGGAGGCCATCTACTGT
GATGACATGCCTCTGGTGGACCAGGAACTTTTCTTGACTTTTGTGACTAGTTCAAGAGCT
CATGCTAAGATTGTGTCTATTGATCTGTCAGAAGCTCTCAGCATGCCCGGTGTGGTGGAC
ATCATGACAGCAGAACATCTTAGTGACGTCAACTCCTTCTGCTTTTTTACTGAAGCTGAG
AAATTTCTGGCGACAGATAAGGTGTTCTGTGTGGGTCAGCTTGTCTGTGCTGTGCTTGCC
GATTCTGAGGTTCAGGCAAAGCGAGCTGCTAAGCGAGTGAAGATTGTCTATCAAGACTTG
GAGCCGCTGATACTAACAATTGAGGAAAGTATACAACACAACTCCTCCTTCAAGCCAGAA
AGGAAACTGGAATATGGAAATGTTGACGAAGCATTTAAAGTGGTTGATCAAATTCTTGAA
GGTGAAATACATATGGGAGGTCAAGAACATTTTTATATGGAAACCCAAAGCATGCTTGTC
GTTCCCAAGGGAGAGGATCAAGAAATGGATGTCTACGTGTCCACACAGTTTCCCAAATAT
ATACAGGACATTGTTGCCTCAACCTTGAAGCTCCCAGCTAACAAGGTCATGTGCCATGTA
AGGCGTGTTGGTGGAGCGTTTGGAGGGAAGGTGTTAAAAACCGGAATCATTGCAGCCGTC
ACTGCATTTGCCGCAAACAAACATGGCCGTGCAGTTCGCTGTGTTCTGGAACGAGGAGAA
GACATGTTAATAACTGGAGGCCGCCATCCTTACCTTGGAAAGTACAAAGCTGGATTCATG
AACGATGGCAGAATCTTGGCCCTGGACATGGAGCATTACAGCAATGCAGGCGCCTCCTTG
GATGAATCATTATTCGTGATAGAAATGGGACTTCTGAAAATGGACAATGCTTACAAGTTT
CCCAATCTCCGCTGCCGGGGTTGGGCATGCAGAACCAACCTTCCATCCAACACAGCTTTT
CGTGGGTTTGGCTTTCCTCAGGCAGTGCTGATCACCGAATCTTGTATCACGGAAGTTGCA
GCCAAATGTGGACTATCCCCTGAGAAGGTGCGAATCATAAACATGTACAAGGAAATTGAT
CAAACACCCTACAAACAAGAGATCAATGCCAAGAACCTAATCCAGTGTTGGAGAGAATGT
ATGGCCATGTCTTCCTACTCCTTGAGGAAAGTTGCTGTGGAAAAGTTCAATGCAGAGAAT
TATTGGAAGAAGAAAGGACTGGCCATGGTCCCCCTGAAGTTTCCTGTTGGCCTTGCGTCA
CGTGCTGCTGGTCAGGCTGCTGCCTTGGTTCACATTTATCTTGATGGCTCTGTGCTGGTC
ACTCACGGTGGAATTGAAATGGGGCAGGGGGTCCACACTAAAATGATTCAGGTGGTCAGC
CGTGAATTAAGAATGCCAATGTCGAATGTCCACCTGCGTGGAACAAGCACAGAAACTGTC
CCTAATGCAAATATCTCTGGAGGTTCTGTGGTGGCAGATCTCAACGGTTTGGCAGTAAAG
GATGCCTGTCAAACTCTTCTAAAACGCCTCGAACCCATCATCAGCAAGAATCCTAAAGGA
ACTTGGAAAGACTGGGCACAGACTGCTTTTGATGAAAGCATTAACCTTTCAGCTGTTGGA
TACTTCAGAGGTTATGAGTCAGACATGAACTGGGAGAAAGGCGAAGGCCAGCCCTTCGAA
TACTTTGTTTATGGAGCTGCCTGTTCCGAGGTTGAAATAGACTGCCTGACGGGGGATCAT
AAGAACATCAGAACAGACATTGTCATGGATGTTGGCTGCAGTATAAATCCAGCCATTGAC
ATAGGCCAGATTGAAGGTGCATTTATTCAAGGCATGGGACTTTATACAATAGAGGAACTG
AATTATTCTCCCCAGGGCATTCTGCACACTCGTGGTCCAGACCAATATAAAATCCCTGCC
ATCTGTGACATGCCCACGGAGTTGCACATTGCTTTGTTGCCTCCTTCTCAAAACTCAAAT
ACTCTTTATTCATCTAAGGGTCTGGGAGAGTCGGGGGTGTTCCTGGGGTGTTCCGTGTTT
TTCGCTATCCATGACGCAGTGAGTGCAGCACGACAGGAGAGAGGCCTGCATGGACCCTTG
ACCCTTAATAGTCCACTGACCCCGGAGAAGATTAGGATGGCCTGTGAAGACAAGTTCACA
AAAATGATTCCGAGAGATGAACCTGGATCCTACGTTCCTTGGAATGTACCCATCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
L11005

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_1_Locus:
2q33

# Metabolic_Enzyme_1_SNPs:
rs41309768; rs3731722; rs2540065; rs1050887; rs1050884; rs2465665; rs2470900; rs2002957; rs1405984; rs2348021; rs2463492; rs2287013; rs868810; rs2465663; rs1527948; rs1527944; rs2463488; rs2348023; rs2470899; rs2465657; rs2254576; rs1527947; rs2348020; rs6753383; rs6745304; rs3769832; rs1918720; rs6753463; rs1986415; rs2293529; rs2470897; rs2293526; rs6712290; rs1527945; rs4428003; rs4619591; rs9288313; rs4496322; rs2540069; rs3795968; rs6725945; rs2470902; rs6720189; rs7560168; rs2293527; rs7597590; rs2248130; rs4672865; rs10497866; rs13400369; rs2293524; rs2287012; rs3815502; rs3815503; rs2256977; rs4672866; rs2715905; rs7597713; rs12478624; rs4614918; rs2293525; rs2465661; rs7563522; rs2293528; rs7572503; rs7587871; rs4674311; rs7585422; rs10187029; rs6742109; rs12693921; rs2241080; rs13419464; rs4672863; rs16833921; rs17448359; rs6737912; rs2465662; rs2241079; rs6760616; rs4674247; rs7563294; rs10172572; rs7420798; rs4672858; rs12997909; rs6761840; rs4470327; rs11677071; rs1405985; rs6435060; rs6730068; rs3769833; rs17593811; rs6761375; rs2463489; rs1986414; rs2881811; rs17532777; rs2347864; rs17533238; rs2244004; rs11694112; rs4035120; rs10469649; rs17532875; rs10432435; rs2287008; rs2348024; rs11689822; rs11886414; rs12617551; rs6730363; rs16833889; rs10497853; rs17532973; rs7586707; rs2540067; rs1405986; rs12618843; rs2465664; rs12472360; rs4541241; rs2348025; rs17532798; rs17448345; rs10497865; rs13404701; rs11887334; rs13023526; rs12993621; rs2287010; rs3769835; rs12472146; rs13383127; rs2715904; rs2348026; rs10183589; rs12612264; rs4672890; rs2960198; rs17533140; rs6732225; rs4456685; rs2347866; rs12478294; rs10180210; rs10469650; rs10469754; rs7426150; rs11897036; rs17532861; rs10179330; rs16833885; rs17533070; rs6711025; rs6761252; rs10931910; rs10204846; rs2540068; rs10931908; rs1527946; rs2247553; rs10206891; rs17533245; rs17448443; rs13419468; rs4674302; rs4503970; rs2715910; rs2465658; rs6754573; rs4508579; rs17448796; rs12620550; rs17448686; rs12620549; rs4674211; rs12620402; rs2715908; rs2287011; rs1986390; rs2287007; rs7562507; rs3769834; rs6735253; rs17636860; rs10207809; rs16833843; rs7595235; rs17448457; rs13406379; rs2960199; rs4674303; rs7569193; rs2463490; rs12612263; rs10183184; rs6724797; rs2715907; rs10179964; rs7598198; rs4337457; rs2516310; rs2347865; rs3820973; rs10210831; rs2540066; rs17448366; rs2072034; rs12621063; rs2715906; rs16833793; rs35345784; rs35217482; rs35128788; rs34799295; rs13023698; rs35999824; rs13408225; rs16833923; rs1050883; rs34427902; rs1131360; rs1050880; rs35293679; rs34110600; rs2241078; rs2348022; rs36084232; rs34698837; rs34892292; rs2463491; rs2470898; rs35076002; rs34217541; rs41270243; rs2715912; rs4674312; rs34095667; rs13402885; rs34380410; rs17594160; rs34436757; rs35754442; rs35527063; rs11901126; rs10460401; rs2465656; rs10192757; rs2287009; rs10179743; rs34769434; rs34936215; rs11420110; rs35886858; rs4384770; rs35423095; rs34397235; rs35057419; rs6741421; rs35569511; rs34169163; rs35035526; rs34423504; rs36054632; rs17533098; rs12466511; rs34606301; rs12464348; rs2470901; rs4350730; rs16833848; rs34138997; rs34016786; rs13008443; rs34185958; rs6435057; rs4672864; rs34356762; rs17448436; rs34831618; rs35918797; rs13391622; rs35794546; rs6147125; rs13034124; rs35778058; rs2960200; rs10192320; rs13423540; rs6728850; rs12993144; rs6728655; rs3769831; rs10931909; rs35245400; rs34772975; rs12988162; rs10623702; rs35236730; rs11373771; rs34817848; rs35482569; rs13035983; rs34032166; rs35483227; rs35482626; rs10191685; rs4035251; rs5018931; rs34962228; rs35020940; rs35045512; rs13019825; rs34887452; rs13393615; rs41271445; rs35698374; rs4622702; rs35086177; rs11676316; rs34332493; rs35539595; rs4674202; rs6147126; rs9808414; rs10203810; rs10192066; rs2465659; rs11455886; rs34798357; rs11397147; rs4261701; rs34408231; rs34266344; rs35993423; rs34473107; rs34930734; rs3038607; rs34303220; rs13432214; rs13432700; rs34560359; rs1989739; rs2715911; rs41270241; rs35309776; rs35763564; rs35987427; rs11684094; rs13385678; rs34620856; rs5837752; rs4621154; rs34299045; rs34602028; rs34451961; rs10664948; rs6750300; rs34882667; rs34272316; rs35908613; rs36046548; rs13398115; rs11680797; rs34570620; rs4674197; rs11370694; rs12621852; rs11677893; rs11678615; rs11684227; rs11691962; rs12622081; rs13026134; rs13027665; rs13419425; rs16834021; rs16834027; rs16834034; rs2540064; rs4132842; rs4132843; rs4674194; rs6729738; rs7563682; rs7594798; rs7607141; rs878403

# Metabolic_Enzyme_1_General_References:
8248161

# Metabolic_Enzyme_1_References:
Not Available

End of HMDB00017

Beginning of HMDB00019
# Accession_No:
HMDB00019

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-23 13:49:32

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
a-Ketoisovaleric acid

# Description:
A branched chain organic acid which is a precursor to leucine and valine synthesis.  It is also a degradation product from valine.  The enzyme dihydroxy-acid dehydratase catalyzes the fourth step in the biosynthesis of isoleucine and valine, through the dehydration of 2, 3-dihydroxy-isovaleic acid into alpha-ketoisovaleric acid.

# Synonyms:
2-Ketoisovalerate; 2-Ketoisovaleric acid; 2-Oxo-3-methylbutanoate; 2-Oxo-3-methylbutanoic acid; 2-Oxo-3-methylbutyrate; 2-Oxo-3-methylbutyric acid; 2-Oxoisovalerate; 2-Oxoisovaleric acid; 2-keto-3-Methylbutyrate; 2-keto-3-Methylbutyric acid; 3-Methyl-2-oxobutanoate; 3-Methyl-2-oxobutanoic acid; 3-Methyl-2-oxobutyrate; 3-Methyl-2-oxobutyric acid; 3-methyl-2-oxo-Butanoate; 3-methyl-2-oxo-Butanoic acid; 3-methyl-2-oxo-Butyrate; 3-methyl-2-oxo-Butyric acid; Dimethylpyruvate; Dimethylpyruvic acid; Isopropylglyoxylate; Isopropylglyoxylic acid; Ketovaline; a-Ketoisovalerate; a-Oxo-b-methylbutyrate; a-Oxo-b-methylbutyric acid; a-Oxoisovalerate; a-Oxoisovaleric acid; a-keto-Isovalerate; a-keto-Isovaleric acid; a-keto-b-Methylbutyrate; a-keto-b-Methylbutyric acid; alpha-Ketoisovalerate; alpha-Ketoisovaleric acid; 3-Methyl-2-oxobutinoic acid; alpha-Oxo-beta-methylbutyrate; alpha-Oxo-beta-methylbutyric acid; alpha-Oxoisovalerate; alpha-Oxoisovaleric acid; alpha-keto-Isovalerate; alpha-keto-Isovaleric acid; alpha-keto-beta-Methylbutyrate; alpha-keto-beta-Methylbutyric acid

# Chemical_IUPAC_Name:
3-methyl-2-oxo-butanoic acid

# Chemical_Formula:
C5H8O3

# Chemical_Structure:
tbl_chemical:::HMDB00019_ZOOM.png:::11928313195321121

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00019_THUMB.png:::119283131764430951

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
ketone; carboxylic acid

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
116.04735

# Molecular_Weight_Avg:
116.11522

# Smiles_String_isomeric:
CC(C)C(=O)C(O)=O

# Smiles_String_canonical:
CC(C)C(=O)C(O)=O

# KEGG_Compound_ID:
C00141

# BioCyc_ID:
2-KETO-ISOVALERATE

# PubChem_CID:
49

# PubChem_SID:
824662; 821865; 7888552; 8150431; 1955; 828266; 207009; 832649; 6591379; 3441; 8144675

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
34011

# Wikipedia_ID:
Not Available

# METLIN_ID:
5091

# Ref_ID:
2089249; 2026685; 7115325; 6422161; 6895847; 9869358; 5096137; 6393856; 6581765

# ChEBI_ID:
16530

# CAS_Registry_Number:
759-05-7

# InChI:
InChI=1/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)

# Synthesis_Reference:
Bouveault, L. etal., Bull. Soc. Chim. Fr., 1901, 1031; Singh, J. etal., Org. Prep. Proced. Int., 1989, 21, 501; Hata, H. etal., Synthesis, 1991, 289

# Melting_Point:
31.5 oC

# Melting_Point_predicted:
24.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
1000.0 mg/mL [MEYLAN,WM et al. (1996)]; 30.2 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
0.49 [Predicted by ALOGPS]; 0.1 [Predicted by PubChem via XLOGP]; -0.33 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00141.mol:::1132723801500830098

# SDF_File_[Text]:
tbl_chemical:::HMDB00019.sdf:::119283131422058484

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00019.pdb:::119283131601531789

# PDB_ID:
1HJG

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1HJG.txt:::1132720898859394396

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::061109_P00_17_1DP_noesy.png:::116890067315368550286

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::2_ketoisovalerate_NOESY-64nt_18dec06.fid.zip:::116655352084382847

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::061109_P00_17_1DP_Assigned.png:::118045513911514511

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::061109_P00_17_IS_2DHSQC_1954.png:::117147669883643953

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::061109_P00_17_IS_2DHSQC_1954.zip:::117147669884856102

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::061109_P00_17_IS_2DHSQC_1954_Assigned.png:::117147669901768156

# Predicted_H_NMR_Spectrum:
tbl_chemical:::3-methyl-2-oxo-Butanoic acid.gif:::1132732099203590048

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00019_peaks.txt:::1156309488303539646

# Predicted_C_NMR_Spectrum:
tbl_chemical:::3-methyl-2-oxo-Butanoic acid_C.gif:::1132737658178847141

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00019_peaks.txt:::1156310680269541330

# Mass_Spectrum:
Low Energy:tbl_ms:::00019L.png:::117891216966736364; Medium Energy:tbl_ms:::00019M.png:::117924567268334658Low Energy:tbl_ms:::negHMDB00019L.png:::118496310054080784; Medium Energy:tbl_ms:::negHMDB00019M.png:::118496310050451058; High Energy:tbl_ms:::negHMDB00019H.png:::118496310054396817

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000101.png:::116899931284336646

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000101.txt:::116899931284310418

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000101.png:::116890826996846977

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000101.txt:::11689082702969157

# Cellular_Location:
Cytoplasm; mitochondria

# Tissue_Location:
Most Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	0.13 (0.00-0.54)	umol/mmol_creatinine	Adult:>18_yrs_old	Male	Normal	9869358
Urine	0.07 (0.01-0.45)	umol/mmol_creatinine	Adult:>18_yrs_old	Female	Normal	5096137
Blood	14.0 (0.0-28.0)	umol/L	Adult:>18_yrs_old	Both	Normal	8412012
Blood	11.0 +/- 1.7	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	8.2 +/- 6.8 	uM	Adult:>18_yrs_old	Both	Normal	8412012


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Friedreich's Ataxia; Maple Syrup Urine Disease (MSUD)

# Pathway_Names:
Valine, leucine and isoleucine degradation;Valine, leucine and isoleucine biosynthesis;Pantothenate and CoA biosynthesis;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
valine,leucine,and_isoleucine_degradation.jpg;Valine,leucine,and_isoleucine_biosynthesis.jpg;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00280;map00290;map00770;map00280;map00280

# Pathway_Graphs:
valine,leucine,and_isoleucine_degradation_Graph.jpg;Valine,leucine,and_isoleucine_biosynthesis_Graph.jpg;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
valine,leucine,and_isoleucine_degradation.xml;Valine,leucine,and_isoleucine_biosynthesis.xml;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5763

# Metabolic_Enzyme_1_Name:
Branched-chain-amino-acid aminotransferase, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
BCAT(m; Placental protein 18; PP18

# Metabolic_Enzyme_1_Gene_Name:
BCAT2

# Metabolic_Enzyme_1_Protein_Sequence:
>Branchedchainaminoacid aminotransferase, mitochondrial precursor
MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKT
FTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRP
WLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSL
GVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLV
QQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQS
LLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIP
TMENGPELILRFQKELKEIQYGIRAHEWMFPV

# Metabolic_Enzyme_1_Number_of_Residues:
392

# Metabolic_Enzyme_1_Molecular_Weight:
44288

# Metabolic_Enzyme_1_Theoretical_pI:
8.82

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
Function:  branched-chain-amino-acid transaminase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  branched chain family amino acid metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids

# Metabolic_Enzyme_1_Pathway:
map00280  Valine, leucine and isoleucine degradation;
 map00290  Valine, leucine and isoleucine biosynthesis;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_1_Reaction:
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01063:Aminotran_4

# Metabolic_Enzyme_1_Signals:
1-29

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.6.1.42

# Metabolic_Enzyme_1_GenBank_ID_Protein:
2342862

# Metabolic_Enzyme_1_SwissProt_ID:
BCAT2_HUMAN (O15382)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
BCAT2

# Metabolic_Enzyme_1_Geneatlas_id:
BCAT2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:977

# Metabolic_Enzyme_1_PDB_ID:
1KTA

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Isoform A:Mitochondrion. Isoform B:Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1179 bp
ATGGCCGCAGCCGCTCTGGGGCAGATCTGGGCACGAAAGCTTCTCTCTGTCCCTTGGCTT
CTGTGTGGTCCCAGAAGATATGCCTCCTCCAGTTTCAAGGCTGCAGACCTGCAGCTGGAA
ATGACACAGAAGCCTCATAAGAAGCCTGGCCCCGGCGAGCCCCTGGTGTTTGGGAAGACA
TTTACCGACCACATGCTGATGGTGGAATGGAATGACAAGGGCTGGGGCCAGCCCCGAATC
CAGCCCTTCCAGAACCTCACGCTGCACCCAGCCTCCTCCAGCCTCCACTACTCCCTGCAG
CTGTTTGAGGGCATGAAGGCGTTCAAAGGCAAAGACCAGCAGGTGCGCCTCTTCCGCCCC
TGGCTCAACATGGACCGGATGCTGCGCTCAGCCATGCGCCTGTGCCTGCCGAGTTTCGAC
AAGCTGGAGTTGCTGGAGTGCATCCGCCGGCTCATCGAAGTGGACAAGGACTGGGTCCCC
GATGCCGCCGGCACCAGCCTCTATGTGCGGCCTGTGCTCATTGGGAACGAGCCCTCGCTG
GGTGTCAGCCAGCCCAGGCGCGCGCTCCTGTTCGTCATTCTCTGCCCAGTGGGTGCCTAC
TTCCCTGGAGGCTCCGTGACCCCGGTCTCCCTCCTGGCCGACCCAGCCTTCATCCGGGCC
TGGGTGGGCGGGGTCGGCAACTACAAGTTAGGTGGGAATTATGGGCCCACCGTGTTAGTG
CAACAGGAGGCACTCAAGCGGGGCTGTGAACAGGTCCTCTGGCTGTATGGGCCCGACCAC
CAGCTCACCGAGGTGGGAACCATGAACATCTTTGTCTACTGGACCCACGAAGATGGGGTG
CTGGAGCTGGTGACGCCCCCGCTGAATGGTGTTATCCTGCCTGGAGTGGTCAGACAGAGT
CTACTGGACATGGCTCAGACCTGGGGTGAGTTCCGGGTGGTGGAGCGCACGATCACCATG
AAGCAGTTGCTGCGGGCCTTGGAGGAGGGCCGCGTGCGGGAAGTCTTTGGCTCGGGCACC
GCTTGCCAGGTCTGCCCAGTGCACCGAATCCTGTACAAAGACAGGAACCTCCATATTCCC
ACCATGGAAAATGGGCCTGAGCTGATCCTCCGCTTCCAGAAGGAGCTGAAGGAGATCCAG
TACGGAATCAGAGCCCACGAGTGGATGTTCCCGGTGTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U68418

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_1_Locus:
19q13

# Metabolic_Enzyme_1_SNPs:
rs11548193; rs837642; rs736170; rs566869; rs491459; rs4802507; rs4802509; rs4802508; rs521398; rs557106; rs12461998; rs4802510; rs11881788; rs575737; rs7257533; rs857526; rs4802504; rs35829476; rs526744; rs4801775; rs4801776; rs4802505; rs493841; rs6509405; rs684959; rs7249134; rs11665957; rs11548194; rs11548192; rs1132361; rs1052611; rs1052625; rs5828363; rs34189956; rs7251049; rs11310101; rs487703; rs41347145; rs7256054; rs7252854; rs11460106; rs35104437; rs3057799; rs35321803; rs35330344; rs34746454; rs11426980; rs12978094; rs11672905; rs10624703; rs34719140; rs34860510; rs11882009; rs11673677; rs12985962; rs35890345; rs34816112; rs12984148; rs35775607; rs35150864; rs35945446; rs4802506; rs34867589; rs11671146; rs35230038; rs10408884; rs36021046; rs35343377; rs36046536; rs1045379; rs11670491; rs11881731; rs11881904; rs12974796; rs2098684; rs3185254; rs35299026; rs3760788; rs482226; rs511779; rs524581; rs524942; rs545587; rs624028; rs656190; rs704244

# Metabolic_Enzyme_1_General_References:
9165094; 11170829; 8702755; 11264579; 12269802

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5534

# Metabolic_Enzyme_2_Name:
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor

# Metabolic_Enzyme_2_Synonyms:
Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta

# Metabolic_Enzyme_2_Gene_Name:
BCKDHB

# Metabolic_Enzyme_2_Protein_Sequence:
>2oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor
MAVVAAAAGWLLRLRAAGAEGHWRRLPGAGLARGFLHPAATVEDAAQRRQVAHFTFQPDP
EPREYGQTQK
MNLFQSVTSALDNSLAKDPTAVIFGEDVAFGGVFRCTVGLRDKYGKDRV
FNTPLCEQGIVGFGIGIAVTG
ATAIAEIQFADYIFPAFDQIVNEAAKYRYRSGDLFNCG
SLTIRSPWGCVGHGALYHSQSPEAFFAHCPGI
KVVIPRSPFQAKGLLLSCIEDKNPCIF
FEPKILYRAAAEEVPIEPYNIPLSQAEVIQEGSDVTLVAWGTQ
VHVIREVASMAKEKLG
VSCEVIDLRTIIPWDVDTICKSVIKTGRLLISHEAPLTGGFASEISSTVQEECF
LNLEA
PISRVCGYDTPFPHIFEPFYIPDKWKCYDALRKMINY

# Metabolic_Enzyme_2_Number_of_Residues:
392

# Metabolic_Enzyme_2_Molecular_Weight:
43123

# Metabolic_Enzyme_2_Theoretical_pI:
6.24

# Metabolic_Enzyme_2_GO_Classification:
Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3)

# Metabolic_Enzyme_2_Pathway:
map00280  Valine, leucine and isoleucine degradation

# Metabolic_Enzyme_2_Reaction:
3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF02779:Transket_pyr;
PF02780:Transketolase_C

# Metabolic_Enzyme_2_Signals:
1-19

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.2.4.4

# Metabolic_Enzyme_2_GenBank_ID_Protein:
179362

# Metabolic_Enzyme_2_SwissProt_ID:
ODBB_HUMAN (P21953)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
BCKDHB

# Metabolic_Enzyme_2_Geneatlas_id:
BCKDHB

# Metabolic_Enzyme_2_hgnc_id:
HGNC:987

# Metabolic_Enzyme_2_PDB_ID:
1X80

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_2_Gene_Sequence:
>1179 bp

ATGGCGGTTGTAGCGGCGGCTGCCGGCTGGCTACTCAGGCTCAGGGCGGCAGGGGCTGA
GGGGCACTGGC
GTCGGCTTCCTGGCGCGGGGCTGGCGCGGGGCTTTTTGCACCCCGCCG
CGACTGTCGAGGATGCGGCCCA
GAGGCGGCAGGTGGCTCATTTTACTTTCCAGCCAGAT
CCGGAGCCCCGGGAGTACGGGCAAACTCAGAAA
ATGAATCTTTTCCAGTCTGTAACAAG
TGCCTTGGATAACTCATTGGCCAAAGATCCTACTGCAGTAATAT
TTGGTGAAGATGTTG
CCTTTGGTGGAGTCTTTAGATGCACTGTTGGCTTGCGAGACAAATATGGAAAAGA
TAGA
GTTTTTAATACCCCATTGTGTGAACAAGGAATTGTTGGATTTGGAATCGGAATTGCGGTC
ACTGGA
GCTACTGCCATTGCGGAAATTCAGTTTGCAGATTATATTTTCCCTGCATTTGA
TCAGATTGTTAATGAAG
CTGCCAAGTATCGCTATCGCTCTGGGGATCTTTTTAACTGTG
GAAGCCTCACTATCCGGTCCCCTTGGGG
CTGTGTTGGTCATGGGGCTCTCTATCATTCT
CAGAGTCCTGAAGCATTTTTTGCCCATTGCCCAGGAATC
AAGGTGGTTATACCCAGAAG
CCCTTTCCAGGCCAAAGGACTTCTTTTGTCATGCATAGAGGATAAAAATC
CTTGTATAT
TTTTTGAACCTAAAATACTTTACAGGGCAGCAGCGGAAGAAGTCCCTATAGAACCATACA
A
CATCCCACTGTCCCAGGCCGAAGTCATACAGGAAGGGAGTGATGTTACTCTAGTTGCC
TGGGGCACTCAG
GTTCATGTGATCCGAGAGGTAGCTTCCATGGCAAAAGAAAAGCTTGG
AGTGTCTTGTGAAGTCATTGATC
TGAGGACTATAATACCTTGGGATGTGGACACAATTT
GTAAGTCTGTGATCAAAACAGGGCGACTGCTAAT
CAGTCACGAGGCTCCCTTGACAGGC
GGCTTTGCATCGGAAATCAGCTCTACAGTTCAGGAGGAATGTTTC
TTGAACCTAGAGGC
TCCTATATCAAGAGTATGTGGTTATGACACACCATTTCCTCACATTTTTGAACCAT
TCT
ACATCCCAGACAAATGGAAGTGTTATGATGCCCTTCGAAAAATGATCAACTATTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M55575

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_2_Locus:
6q13-q15

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
2365818; 8651316; 2335211; 7918575; 8161368

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5536

# Metabolic_Enzyme_3_Name:
Branched-chain-amino-acid aminotransferase, cytosolic

# Metabolic_Enzyme_3_Synonyms:
BCAT(c; ECA39 protein

# Metabolic_Enzyme_3_Gene_Name:
BCAT1

# Metabolic_Enzyme_3_Protein_Sequence:
>Branchedchainaminoacid aminotransferase, cytosolic
MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTV
EWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRM
YRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPTK
ALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEAVDN
GCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQ
WGEFKVSERYLTMDDLSTALEGNRVREMFGSGTACVVCPVSDILYKGETIHIPTMENGPK
LASRILSKLTDIQYGREESDWTIVLS

# Metabolic_Enzyme_3_Number_of_Residues:
386

# Metabolic_Enzyme_3_Molecular_Weight:
42953

# Metabolic_Enzyme_3_Theoretical_pI:
4.95

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
Function:  branched-chain-amino-acid transaminase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  branched chain family amino acid metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine

# Metabolic_Enzyme_3_Pathway:
map00280  Valine, leucine and isoleucine degradation;
 map00290  Valine, leucine and isoleucine biosynthesis;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_3_Reaction:
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01063:Aminotran_4

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.6.1.42

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1036780

# Metabolic_Enzyme_3_SwissProt_ID:
BCAT1_HUMAN (P54687)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
BCAT1

# Metabolic_Enzyme_3_Geneatlas_id:
BCAT1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:976

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>1155 bp
ATGGATTGCAGTAACGGATCGGCAGAGTGTACCGGAGAAGGAGGATCAAAAGAGGTGGTG
GGGACTTTTAAGGCTAAAGACCTAATAGTCACACCAGCTACCATTTTAAAGGAAAAACCA
GACCCCAATAATCTGGTTTTTGGAACTGTGTTCACGGATCATATGCTGACGGTGGAGTGG
TCCTCAGAGTTTGGATGGGAGAAACCTCATATCAAGCCTCTTCAGAACCTGTCATTGCAC
CCTGGCTCATCAGCTTTGCACTATGCAGTGGAATTATTTGAAGGATTGAAGGCATTTCGA
GGAGTAGATAATAAAATTCGACTGTTTCAGCCAAACCTCAACATGGATAGAATGTATCGC
TCTGCTGTGAGGGCAACTCTGCCGGTATTTGACAAAGAAGAGCTCTTAGAGTGTATTCAA
CAGCTTGTGAAATTGGATCAAGAATGGGTCCCATATTCAACATCTGCTAGTCTGTATATT
CGTCCTGCATTCATTGGAACTGAGCCTTCTCTTGGAGTCAAGAAGCCTACCAAAGCCCTG
CTCTTTGTACTCTTGAGCCCAGTGGGACCTTATTTTTCAAGTGGAACCTTTAATCCAGTG
TCCCTGTGGGCCAATCCCAAGTATGTAAGAGCCTGGAAAGGTGGAACTGGGGACTGCAAG
ATGGGAGGGAATTACGGCTCATCTCTTTTTGCCCAATGTGAAGACGTAGATAATGGGTGT
CAGCAGGTCCTGTGGCTCTATGGCAGAGACCATCAGATCACTGAAGTGGGAACTATGAAT
CTTTTTCTTTACTGGATAAATGAAGATGGAGAAGAAGAACTGGCAACTCCTCCACTAGAT
GGCATCATTCTTCCAGGAGTGACAAGGCGGTGCATTCTGGACCTGGCACATCAGTGGGGT
GAATTTAAGGTGTCAGAGAGATACCTCACCATGGATGACTTGACAACAGCCCTGGAGGGG
AACAGAGTGAGAGAGATGTTTAGCTCTGGTACAGCCTGTGTTGTTTGCCCAGTTTCTGAT
ATACTGTACAAAGGCGAGACAATACACATTCCAACTATGGAGAATGGTCCTAAGCTGGCA
AGCCGCATCTTGAGCAAATTAACTGATATCCAGTATGGAAGAGAAGAGAGCGACTGGACA
ATTGTGCTATCCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U21551

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_3_Locus:
12pter-q12

# Metabolic_Enzyme_3_SNPs:
rs7313020; rs17374285; rs1872644; rs2220269; rs1872645; rs6487421; rs2353483; rs4453321; rs6487420; rs1054277; rs2353481; rs1471842; rs1043851; rs3198082; rs1054281; rs1054279; rs1043881; rs12371993; rs4963801; rs7296995; rs7305794; rs2029986; rs11486; rs2200509; rs12578267; rs6487419; rs2353482; rs2046524; rs3825167; rs11047652; rs7134734; rs11047654; rs12231434; rs10842409; rs11047724; rs17371571; rs7134619; rs7306168; rs7315828; rs7134871; rs1872646; rs2046525; rs1471844; rs976436; rs2291894; rs2173606; rs2062497; rs2242400; rs7954529; rs3759085; rs1813470; rs7310300; rs11613673; rs7297229; rs4963596; rs11047676; rs6487428; rs10842418; rs10842431; rs937503; rs7296211; rs2029985; rs4963820; rs2046526; rs6487431; rs7296881; rs10771144; rs11610069; rs2352745; rs12425320; rs6487436; rs11047684; rs954200; rs3736212; rs2242399; rs7976928; rs7977807; rs4462438; rs6487435; rs7299023; rs7964239; rs12319639; rs954199; rs10466757; rs12424348; rs7968890; rs10505954; rs2133587; rs11047717; rs718567; rs11047686; rs7975904; rs3759086; rs10842413; rs6487434; rs11047679; rs4963822; rs7312749; rs6487429; rs2352746; rs16928083; rs10842414; rs7969149; rs3950612; rs10505952; rs10771142; rs6487437; rs16928141; rs12422599; rs2129236; rs1566406; rs12580682; rs10771138; rs4963810; rs2133588; rs16928207; rs16928163; rs16928145; rs12423866; rs4531567; rs16928217; rs6487433; rs11047685; rs2133582; rs11047716; rs10842429; rs7305924; rs7967945; rs1499805; rs11047709; rs7956863; rs7299760; rs11047692; rs12424211; rs7962203; rs954201; rs4963830; rs11609552; rs2047554; rs10771132; rs10842415; rs11047707; rs7959036; rs2353478; rs10505955; rs11047689; rs1546197; rs10842423; rs4143211; rs16928097; rs11047696; rs4963814; rs11047682; rs7978032; rs10771133; rs11608526; rs12318469; rs4963818; rs10160847; rs12366540; rs16928111; rs1119693; rs1566407; rs2353472; rs10842420; rs6487430; rs10842424; rs17314214; rs1392196; rs4143210; rs924191; rs11047708; rs1546196; rs12320158; rs1497257; rs4963594; rs10743524; rs10842416; rs3736211; rs12579934; rs12321766; rs10771140; rs10842427; rs10842433; rs7960010; rs10128933; rs7313260; rs16928089; rs7972930; rs7298696; rs1391028; rs12302883; rs10771139; rs10771130; rs9804952; rs7303413; rs4963804; rs10842421; rs7978793; rs12227915; rs7973974; rs10842417; rs2047555; rs7970244; rs10505953; rs4963808; rs1392195; rs10771128; rs7138654; rs2201712; rs10771141; rs10771127; rs11047674; rs7961778; rs2306766; rs11835201; rs3759088; rs16928168; rs11047693; rs7965655; rs4522264; rs10842422; rs11047665; rs10161442; rs16928173; rs7966104; rs12321731; rs4963805; rs10771146; rs3926539; rs11047712; rs2062495; rs4603392; rs11047711; rs11047721; rs2883181; rs1471843; rs12427117; rs10743526; rs12296255; rs11615930; rs12422783; rs11047697; rs11047706; rs4963802; rs1105937; rs11833854; rs10771129; rs4963823; rs17313239; rs10771143; rs10771134; rs10466799; rs7136436; rs10743521; rs7969444; rs17315488; rs12579655; rs12172778; rs7138685; rs3759087; rs4406910; rs1875092; rs11047677; rs2133589; rs7967953; rs7955672; rs7398085; rs7484721; rs10047592; rs12318827; rs11615863; rs4963806; rs4963821; rs12322309; rs11830394; rs7976171; rs16928186; rs11047714; rs11047668; rs4459405; rs7966783; rs10743525; rs12229422; rs6487427; rs12817139; rs1075061; rs4246225; rs7953453; rs12230816; rs12322341; rs7969612; rs12320547; rs12818299; rs11047700; rs11047715; rs7138806; rs1077102; rs17342494; rs2353479; rs17372766; rs7961688; rs4963817; rs11047723; rs12372519; rs17373566; rs5012437; rs12423288; rs16928169; rs11047669; rs7955886; rs11047695; rs17375619; rs17316319; rs1075062; rs12427184; rs7299787; rs11830163; rs12371441; rs11610213; rs2291895; rs11047678; rs11047681; rs9989035; rs11047691; rs11047671; rs11047667; rs11047699; rs12319283; rs12228257; rs4031159; rs12230878; rs11613710; rs11613482; rs4963815; rs7298907; rs7307610; rs11047702; rs2353473; rs10047590; rs10771145; rs12316589; rs17315467; rs1846581; rs1119692; rs2352747; rs10842434; rs11047660; rs7961152; rs11047657; rs10743527; rs7969649; rs1875091; rs4963593; rs7978338; rs4143212; rs4963811; rs16928171; rs11612450; rs12313518; rs2220270; rs2173605; rs11047722; rs4296116; rs10842430; rs16928149; rs7970200; rs12296315; rs10219671; rs2255206; rs2353484; rs2353485; rs3794263; rs7959326; rs10842436; rs1048368; rs2353486; rs10734736; rs7970725; rs1463625; rs1497255; rs7955676; rs1057204; rs35600421; rs17374606; rs4423275; rs35585041; rs11047651; rs35186964; rs12582215; rs15643; rs12366411; rs11433688; rs35804569; rs34453620; rs36085546; rs33947278; rs5797102; rs11047650; rs11384696; rs12301168; rs666928; rs12831930; rs35951011; rs36070747; rs12828108; rs10688526; rs12296452; rs34174229; rs34780357; rs4963819; rs34032061; rs34504461; rs34414606; rs5797104; rs34876959; rs5797105; rs34153775; rs12316475; rs7967922; rs665254; rs34501736; rs12817209; rs35203857; rs12422829; rs12296646; rs866358; rs12301149; rs11047661; rs35989805; rs12820872; rs34044660; rs35455721; rs34556925; rs1874598; rs7485585; rs10585254; rs35693234; rs35550560; rs11370314; rs12228347; rs5797108; rs11047687; rs11415752; rs10466800; rs11047659; rs35850216; rs17314570; rs625604; rs2270771; rs11047683; rs34237642; rs9804807; rs4963809; rs12817395; rs10585144; rs12310054; rs34835991; rs11616042; rs12300357; rs35406045; rs12319312; rs12229613; rs2649778; rs2133584; rs2291896; rs34227038; rs10842432; rs10595838; rs36124065; rs35488171; rs35203074; rs35427447; rs35151527; rs11608755; rs2133585; rs12823840; rs4031157; rs3950611; rs11615196; rs12818315; rs3044337; rs34802588; rs12816139; rs12816228; rs34677835; rs34476055; rs35060237; rs34165520; rs34902696; rs35984920; rs34151647; rs34717106; rs12310217; rs12818883; rs35033368; rs4963595; rs5797106; rs11047719; rs34329602; rs2645897; rs11310819; rs35929602; rs34808872; rs34508149; rs11047670; rs12825177; rs12827517; rs7968043; rs7980970; rs1693356; rs12810541; rs35423225; rs33963375; rs4432099; rs11047655; rs35331816; rs11047710; rs2645908; rs2649777; rs7309420; rs860869; rs10553165; rs28459289; rs12312774; rs11047666; rs35669075; rs12424534; rs11616041; rs35606332; rs17315509; rs12810226; rs11612132; rs35593379; rs2062496; rs10743522; rs11614032; rs7306822; rs35643898; rs11047703; rs35195819; rs2270772; rs2133583; rs11047720; rs35270432; rs34776365; rs11394415; rs28678340; rs10541735; rs35646001; rs840797; rs4963825; rs10643112; rs4963824; rs7970415; rs11047718; rs11047656; rs4963826; rs11327300; rs34707102; rs2133586; rs2883180; rs34370749; rs11440596; rs34430745; rs11392086; rs11047701; rs12319952; rs34143445; rs5797107; rs11047672; rs11047688; rs7296005; rs34780543; rs12227952; rs34331143; rs10561433; rs11318750; rs12230723; rs11047680; rs2645904; rs11345548; rs35939998; rs11614469; rs675368; rs4963807; rs596765; rs35566363; rs11442641; rs34858948; rs12320957; rs34377944; rs12313801; rs35181244; rs4963812; rs10616253; rs36137247; rs7972955; rs2220271; rs11047662; rs35801229; rs11047694; rs10697494; rs12817355; rs2645907; rs12581783; rs4031158; rs35477401; rs4031153; rs667888; rs1622629; rs4963813; rs2649776; rs34705263; rs35978550; rs11047704; rs34761531; rs7975240; rs3044287; rs12818310; rs12818301; rs7308285; rs7953787; rs10546505; rs36067986; rs35477889; rs7136511; rs34706565; rs34990218; rs16928147; rs34860589; rs12229575; rs36036274; rs11047705; rs35440053; rs11320109; rs866357; rs34549035; rs11047673; rs11047663; rs4400889; rs7131753; rs12367115; rs28491628; rs11047713; rs10548732; rs12830129; rs1075063; rs12582334; rs7968607; rs9668094; rs35277052; rs12821845; rs12299696; rs3830305; rs12371444; rs12831941; rs10589289; rs11369972; rs34420618; rs11047690; rs11831592; rs4257068; rs35063724; rs11047664; rs587649; rs10743523; rs10714031; rs11047698; rs668707; rs36035411; rs34285635; rs1497256; rs593165; rs9668028; rs35543389; rs10662028; rs5797103; rs35693867; rs3044290; rs9988971; rs34676819; rs10842435; rs35336188; rs1872643; rs10219508; rs10219610; rs1032589; rs10743520; rs10771123; rs10771124; rs10771125; rs10842408; rs10842437; rs10842439; rs11047645; rs11047647; rs11047648; rs11047726; rs11829886; rs1213075; rs12301529; rs12368831; rs12582944; rs12819423; rs1471841; rs16928015; rs17316445; rs17322922; rs17322957; rs34277634; rs34589683; rs35085353; rs4255624; rs4406909; rs4429151; rs4569089; rs4963795; rs4963796; rs4963797; rs4963800; rs619755; rs6487417; rs7299477; rs7307399; rs7961311; rs7961506; rs7964847; rs7979563; rs7979723

# Metabolic_Enzyme_3_General_References:
8692959

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5535

# Metabolic_Enzyme_4_Name:
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha; BCKDE1A

# Metabolic_Enzyme_4_Gene_Name:
BCKDHA

# Metabolic_Enzyme_4_Protein_Sequence:
>2oxoisovalerate dehydrogenase subunit alpha, mitochondrial precursor
MAVAIAAARVWRLNRGLSQAALLLLRQPGARGLARSHPPRQQQQFSSLDDKPQFPGASAE
FIDKLEFIQP
NVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKLYKSMTLLNTMDRIL
YESQRQGRISFYMTNYGEEGT
HVGSAAALDNTDLVFGQYREAGVLMYRDYPLELFMAQC
YGNISDLGKGRQMPVHYGCKERHFVTISSPLA
TQIPQAVGAAYAAKRANANRVVICYFG
EGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYR
GDGIAARGPGYGIMSI
RVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDE
VNYWD
KQDHPISRLRHYLLSQGWWDEEQEKAWRKQSRRKVMEAFEQAERKPKPNPNLLFSDVYQE
MPAQL
RKQQESLARHLQTYGEHYPLDHFDK

# Metabolic_Enzyme_4_Number_of_Residues:
445

# Metabolic_Enzyme_4_Molecular_Weight:
50472

# Metabolic_Enzyme_4_Theoretical_pI:
8.41

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3)

# Metabolic_Enzyme_4_Pathway:
map00280  Valine, leucine and isoleucine degradation

# Metabolic_Enzyme_4_Reaction:
3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00676:E1_dh

# Metabolic_Enzyme_4_Signals:
1-32

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.2.4.4

# Metabolic_Enzyme_4_GenBank_ID_Protein:
29391

# Metabolic_Enzyme_4_SwissProt_ID:
ODBA_HUMAN (P12694)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
BCKDHA

# Metabolic_Enzyme_4_Geneatlas_id:
BCKDHA

# Metabolic_Enzyme_4_hgnc_id:
HGNC:986

# Metabolic_Enzyme_4_PDB_ID:
1U5B

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_4_Gene_Sequence:
>1338 bp

ATGGCGGTAGCGATCGCTGCAGCGAGGGTCTGGCGGCTAAACCGTGGTTTGAGCCAGGC
TGCCCTCCTGC
TGCTGCGGCAGCCTGGGGCTCGGGGACTGGCTAGATCTCACCCCCCCA
GGCAGCAGCAGCAGTTTTCATC
TCTGGATGACAAGCCCCAGTTCCCAGGGGCCTCGGCG
GAGTTTATAGATAAGTTGGAATTCATCCAGCCC
AACGTCATCTCTGGAATCCCCATCTA
CCGCGTCATGGACCGGCAAGGCCAGATCATCAACCCCAGCGAGG
ACCCCCACCTGCCGA
AGGAGAAGGTGCTGAAGCTCTACAAGAGCATGACACTGCTTAACACCATGGACCG
CATC
CTCTATGAGTCTCAGCGGCAGGGCCGGATCTCCTTCTACATGACCAACTATGGTGAGGAG
GGCACG
CACGTGGGGAGTGCCGCCGCCCTGGACAACACGGACCTGGTGTTTGGCCAGTA
CCGGGAGGCAGGTGTGC
TGATGTATCGGGACTACCCCCTGGAACTATTCATGGCCCAGT
GCTATGGCAACATCAGTGACTTGGGCAA
GGGGCGCCAGATGCCTGTCCACTACGGCTGC
AAGGAACGCCACTTCGTCACTATCTCCTCTCCACTGGCC
ACGCAGATCCCTCAGGCGGT
GGGGGCGGCGTACGCAGCCAAGCGGGCCAATGCCAACAGGGTCGTCATCT
GTTACTTCG
GCGAGGGGGCAGCCAGTGAGGGGGACGCCCATGCCGGCTTCAACTTCGCTGCCACACTTG
A
GTGCCCCATCATCTTCTTCTGCCGGAACAATGGCTACGCCATCTCCACGCCCACCTCT
GAGCAGTATCGC
GGCGATGGCATTGCAGCACGAGGCCCCGGGTATGGCATCATGTCAAT
CCGCGTGGATGGTAATGATGTGT
TTGCCGTATACAACGCCACAAAGGAGGCCCGACGGC
GGGCTGTGGCAGAGAACCAGCCCTTTCTCATCGA
GGCCATGACCTACAGGATCGGGCAC
CACAGCACCAGTGACGACAGTTCAGCGTACCGCTCGGTGGATGAG
GTCAATTACTGGGA
TAAACAGGACCACCCCATCTCCCGGCTGCGGCACTATCTGCTGAGCCAAGGCTGGT
GGG
ATGAGGAGCAGGAGAAGGCCTGGAGGAAGCAGTCCCGCAGGAAGGTGATGGAGGCCTTTG
AGCAGGC
CGAGCGGAAGCCCAAACCCAACCCCAACCTGCTCTTCTCAGACGTGTATCAG
GAGATGCCCGCCCAGCTC
CGCAAGCAGCAGGAGTCTCTGGCCCGCCACCTGCAGACCTA
CGGGGAGCACTACCCACTGGATCACTTCG
ATAAGTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
Z14093

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_4_Locus:
19q13.1-q13.2

# Metabolic_Enzyme_4_SNPs:
rs34589432; rs34442879; rs284652; rs4674; rs10404506; rs34492894; rs284650; rs284656; rs10409485; rs284655; rs1473248; rs6508977; rs11672345; rs4803461; rs4803465; rs284653; rs4803463; rs4803464; rs284654; rs2288871; rs284647; rs3816037; rs11083619; rs10416743; rs284657; rs11880951; rs11670757; rs8108664; rs11879090; rs3213860; rs11880539; rs284658; rs284649; rs2241711; rs12709849; rs4803468; rs4803462; rs284648; rs4802116; rs2241710; rs2288870; rs2241707; rs3217386; rs3217385; rs12459859; rs11670725; rs10420556; rs1967334; rs3213861; rs12327776; rs10418291; rs7258787; rs4803469; rs1967333; rs4802117; rs11670668; rs12982607; rs10415116; rs10422783; rs2241706; rs16975216; rs11670583; rs7258973; rs12980966; rs2241709; rs10413735; rs284651; rs10422226; rs2241708; rs4802118; rs4803467; rs10410801; rs34956071; rs11549938; rs11549937; rs12980789; rs12973059; rs4803466; rs10565264; rs3214612; rs166925; rs35024134; rs10425437; rs10554793; rs10405951; rs3061207; rs35487663; rs11300069; rs9710116; rs11666243; rs13343330; rs11437195; rs8102338; rs34391204; rs35668703; rs10418917; rs34978824; rs34107638; rs12327735; rs10409251; rs10407077; rs10418669; rs10419188; rs2288872; rs12979462; rs34447852; rs10408639; rs11671704; rs10411013; rs35085046; rs34919809; rs12971746; rs5828106; rs10406198; rs11437196; rs10424533; rs13346233; rs11307304; rs10414106; rs34933875; rs28374474; rs5828107; rs10426536; rs11307062; rs12327737; rs11671665; rs11883104; rs33988947; rs35214178; rs35521052; rs7257117; rs10413269; rs10418899; rs10421104; rs10422956; rs10423332; rs1043413; rs1050647; rs10853751; rs11539797; rs11878656; rs12983789; rs17318596; rs2231943; rs2231944; rs2231945; rs2231946; rs284660; rs284661; rs284662; rs284663; rs34169026; rs34500671; rs34541442; rs35286725; rs35615017; rs3810174; rs3810175; rs7248964; rs7249410; rs7259208; rs747239; rs878082; rs878083; rs892044

# Metabolic_Enzyme_4_General_References:
1420356; 2914958; 2060625; 1682165; 3224821; 7918575; 10745006; 8037208; 2703538; 2241958; 1867199; 1885764; 8161368; 7883996

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
8614

# Metabolic_Enzyme_5_Name:
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
Dihydrolipoyllysine-residue; 2-methylpropanoyltransferase; E2; Dihydrolipoamide branched chain transacylase; BCKAD E2 subunit

# Metabolic_Enzyme_5_Gene_Name:
DBT

# Metabolic_Enzyme_5_Protein_Sequence:
>Lipoamide acyltransferase component of branchedchain alphaketo acid dehydrogenase complex, mitochondrial precursor
MAAVRMLRTWSRNAGKLICVRYFQTCGNVHVLKPNYVCFFGYPSFKYSHPHHFLKTTAAL
RGQVVQFKLSDIGEGIREVTVKEWYVKEGDTVSQFDSICEVQSDKASVTITSRYDGVIKK
LYYNLDDIAYVGKPLVDIETEALKDSEEDVVETPAVSHDEHTHQEIKGRKTLATPAVRRL
AMENNIKLSEVVGSGKDGRILKEDILNYLEKQTGAILPPSPKVEIMPPPPKPKDMTVPIL
VSKPPVFTGKDKTEPIKGFQKAMVKTMSAALKIPHFGYCDEIDLTELVKLREELKPIAFA
RGIKLSFMPFFLKAASLGLLQFPILNASVDENCQNITYKASHNIGIAMDTEQGLIVPNVK
NVQICSIFDIATELNRLQKLGSVGQLSTTDLTGGTFTLSNIGSIGGTFAKPVIMPPEVAI
GALGSIKAIPRFNQKGEVYKAQIMNVSWSADHRVIDGATMSRFSNLWKSYLENPAFMLLD
LK

# Metabolic_Enzyme_5_Number_of_Residues:
482

# Metabolic_Enzyme_5_Molecular_Weight:
53488

# Metabolic_Enzyme_5_Theoretical_pI:
8.75

# Metabolic_Enzyme_5_GO_Classification:
>>>
 Function:  binding
Function:  protein binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Energy production and conversion

# Metabolic_Enzyme_5_Specific_Function:
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3)

# Metabolic_Enzyme_5_Pathway:
Not Available

# Metabolic_Enzyme_5_Reaction:
2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00198:2-oxoacid_dh
PF00364:Biotin_lipoyl
PF02817:E3_binding

# Metabolic_Enzyme_5_Signals:
1-15

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.3.1.168

# Metabolic_Enzyme_5_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_5_SwissProt_ID:
ODB2_HUMAN (P11182)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
DBT

# Metabolic_Enzyme_5_Geneatlas_id:
DBT

# Metabolic_Enzyme_5_hgnc_id:
HGNC:2698

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_5_Gene_Sequence:
Not Available

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X66785

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_5_Locus:
1p31

# Metabolic_Enzyme_5_SNPs:
rs12021720; rs11166414; rs7515169; rs7543453; rs2810423; rs4243806; rs7541105; rs2810424; rs10783127; rs4143060; rs4143055; rs6577160; rs4143056; rs4143054; rs3131839; rs7411584; rs6681747; rs6691159; rs2784176; rs4463693; rs6682782; rs4443908; rs6577158; rs6678629; rs10127510; rs2810425; rs12046458; rs7531657; rs10127954; rs10127458; rs10127624; rs7526860; rs4457600; rs17122068; rs6577161; rs12036284; rs6681732; rs17122062; rs4536026; rs12563896; rs11166415; rs11166420; rs4908045; rs12730828; rs11580205; rs11166417; rs6577159; rs6675037; rs6577156; rs10875281; rs4143058; rs4143059; rs4908050; rs12566522; rs3131838; rs12731146; rs11578881; rs4908049; rs4443909; rs6700203; rs12043921; rs12757077; rs11166418; rs4385734; rs11166419; rs4908048; rs4443907; rs6577157; rs11800446; rs4907905; rs4908047; rs7519172; rs3122123; rs4907904; rs10127453; rs4908046; rs17122057; rs12135215; rs3806235; rs3806238; rs7520551; rs3806236; rs3806237; rs2784174; rs34267966; rs34216222; rs2210835; rs12121012; rs1141149; rs1055938; rs1141150; rs36009006; rs11431894; rs12727372; rs34816108; rs34088406; rs11284142; rs10569169; rs12754742; rs34588666; rs12124225; rs6687213; rs10569170; rs36076189; rs34507136; rs10443197; rs10641409; rs35150096; rs12565098; rs35280314; rs5776501; rs4495725; rs4908044; rs4143057; rs11352287; rs36074370; rs9701856; rs34905359; rs35464102; rs9700526; rs12120030; rs36130836; rs11369687; rs4908043; rs36195710; rs34229137; rs11584177; rs35771966; rs34446927; rs12134966; rs4243807; rs3898422; rs12737671; rs12130715; rs36169768; rs12731147; rs36048113; rs35509059; rs10587917; rs10707303; rs11275801; rs35975149; rs34033652; rs4587586; rs35177080; rs34533441; rs34230047; rs35815229; rs10648531; rs28375752; rs33967889; rs12754720; rs35977630; rs12140583; rs35406160; rs11579298; rs10716275; rs12735769; rs14964; rs11394110; rs10680510; rs35766227; rs34976609; rs34912416; rs41287254; rs3122124; rs10747506; rs11166412; rs11166413; rs11801766; rs12044663; rs12085550; rs3122125; rs3131836; rs3131837; rs4397673; rs4604709; rs6577155; rs6701655

# Metabolic_Enzyme_5_General_References:
1420314; 3245861; 2708389; 2742576; 2837277; 1429740; 7918575; 11839747; 1847055; 9621512

# Metabolic_Enzyme_5_References:
Not Available

End of HMDB00019

Beginning of HMDB00020
# Accession_No:
HMDB00020

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-25 13:57:05

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
p-Hydroxyphenylacetic acid

# Description:
An oxidative deaminated metabolite of p-tyramine. Also a metabolite of tyrosine via enteric bacteria.  The bacterial origin of this compound was confirmed by the finding that this compound in urine decreased significantly after the use of the antibiotic neomycin.

# Synonyms:
(4-Hydroxy-phenyl)-essigsaeure; (4-hydroxy-phenyl)-acetate; (4-hydroxy-phenyl)-acetic acid; (4-hydroxyphenyl)acetate; (4-hydroxyphenyl)acetic acid; (p-Hydroxyphenyl)acetate; (p-Hydroxyphenyl)acetic acid; (p-hydroxyphenyl)-Acetate; (p-hydroxyphenyl)-Acetic acid; 4-Hydroxy-Benzeneacetate; 4-Hydroxy-Benzeneacetic acid; 4-Hydroxybenzeneacetate; 4-Hydroxybenzeneacetic acid; 4-hydroxyphenylacetate; 4-hydroxyphenylacetic acid; Parahydroxy phenylacetate; Parahydroxy phenylacetic acid; Parahydroxyphenylacetate; p-hydroxyphenylacetate; p-hydroxyphenylacetic acid

# Chemical_IUPAC_Name:
2-(4-hydroxyphenyl)acetic acid

# Chemical_Formula:
C8H8O3

# Chemical_Structure:
tbl_chemical:::HMDB00020_ZOOM.png:::119283132892118367

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00020_THUMB.png:::119283132697199879

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
phenol or hydroxyhetarene; carboxylic acid; aromatic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
152.04735

# Molecular_Weight_Avg:
152.14732

# Smiles_String_isomeric:
OC(=O)CC1=CC=C(O)C=C1

# Smiles_String_canonical:
OC(=O)CC1=CC=C(O)C=C1

# KEGG_Compound_ID:
C00642

# BioCyc_ID:
4-HYDROXYPHENYLACETATE

# PubChem_CID:
127

# PubChem_SID:
7885355; 8143891; 10387358; 3915; 819277; 11231199; 8001827; 835447; 2029; 8150470; 7990051; 87926; 3133496; 10509268; 86366; 4533640; 152263

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
35599

# Wikipedia_ID:
Not Available

# METLIN_ID:
130

# Ref_ID:
15853358; 11997029; 7116636; 6883916; 6181210; 14708889; 455649; 8087979; 4903899; 12797864; 12971945; 11152462; 6085021; 15721987

# ChEBI_ID:
18101

# CAS_Registry_Number:
156-38-7

# InChI:
InChI=1/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)

# Synthesis_Reference:
Looker, J.H., J.O.C., 1954, 19, 784-788; Bodor, N. etal., J. Med. Chem., 1988, 31, 1651-1656

# Melting_Point:
148-150 oC

# Melting_Point_predicted:
103.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
60.7 mg/mL [GRACIN,S & RASMUSON,AC (2002)]

# H2O_Solubility_Predicted:
7.12 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
0.75 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
0.93 [Predicted by ALOGPS]; 1 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00642.mol:::1132723801593939274

# SDF_File_[Text]:
tbl_chemical:::HMDB00020.sdf:::11928313235011408

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00020.pdb:::119283132529451513

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::050106_P00_06_IS_1DP_presat_1.png:::115272187455710256

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::050106_P00_06_IS_1DP_presat_2.zip:::115272222216267399

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::050106_P00_06_IS_1DP_Assigned.png:::115628170659952754

# C_NMR_Spectra:
tbl_cnmr:::050106_P00_06_IS_1DC_133.png:::114791051506413891

# C_NMR_FIDS_Spectra:
tbl_cnmr:::050106_P00_06_IS_1DC_133.zip:::114791051508932990

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::050106_P00_06_IS_1DC_133_Assigned.png:::115999279896944016

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050106_P00_06_IS_2DHSQC_71.png:::114805641972412517

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050106_P00_06_IS_2DHSQC_71.zip:::114805641973130528

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050106_P00_06_IS_2DHSQC_71_Assigned.png:::115999283803544123

# Predicted_H_NMR_Spectrum:
tbl_chemical:::4-Hydroxyphenylacetic acid.gif:::1132732099250704431

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00020_peaks.txt:::1156309489334549951

# Predicted_C_NMR_Spectrum:
tbl_chemical:::4-Hydroxyphenylacetic acid_C.gif:::1132737658218635811

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00020_peaks.txt:::1156310681295788839

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00020L.png:::117555263318947066; Medium Energy:tbl_ms:::HMDB00020M.png:::117555268523919871; High Energy:tbl_ms:::HMDB00020H.png:::117555271848664169

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; Extracellular

# Tissue_Location:
Bladder; Epidermis; Kidney

# deuterated:
No

# Biofluid_Location:
Blood; Saliva; Urine

# Concentration_[Normal]:
Urine	23 (20-26)	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	14	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	8087979
Urine	30	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	24.2	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	14708889
Urine	36.7	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	14708889
Urine	20.3	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	14708889
Urine	31.4	umol/mmol_creatinine	Adolescent:13-18_yrs_old	Both	Normal	14708889
Urine	15.3	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	14708889
Urine	24.2	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	8087979
Urine	36.7	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	8087979
Urine	20.3	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	31.4	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	15.3	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	8087979
Blood	0.230 (0.070-0.390)	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	4.9 (1.8-8.0)	umol/L	Adult:>18_yrs_old	Both	Normal	17536823
Saliva	7.0 (2.0-10.0)	uM	Adult:>18_yrs_old	Both	Normal	11997029


# Concentration_[Abnormal]:
Urine	16 +/- 15	umol/mmol_creatinine	N/A	Both	Lung Cancer	
Urine	18-150	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Spina bifida	4903899


# Associated_Disorders:
Celiac Disease (Gluten Sensitivity); Enteritis; Epileptic; Intestinal Resection; Lung Cancer; Schizophrenic; Spina bifida

# Pathway_Names:
Glycolysis

# Pathway_Images:
Glycolysis.jpg

# KEGG_Images:
map00010

# Pathway_Graphs:
Glycolysis_Graph.jpg

# Pathway_SBMLs:
Glycolysis.xml

# Metabolic_Enzyme_1_ID:
5810

# Metabolic_Enzyme_1_Name:
Aldehyde dehydrogenase 3B2

# Metabolic_Enzyme_1_Synonyms:
Aldehyde dehydrogenase 8

# Metabolic_Enzyme_1_Gene_Name:
ALDH3B2

# Metabolic_Enzyme_1_Protein_Sequence:
>Aldehyde dehydrogenase 3B2
MKDEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGNCVVLKPSE
ISQGTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAAT
KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLL
PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVL
VDVQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERT
SSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEI
RYPPYTDWNQQLLRWGMGSQSCTLL

# Metabolic_Enzyme_1_Number_of_Residues:
385

# Metabolic_Enzyme_1_Molecular_Weight:
42670

# Metabolic_Enzyme_1_Theoretical_pI:
5.97

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

# Metabolic_Enzyme_1_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_1_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1051281

# Metabolic_Enzyme_1_SwissProt_ID:
AL3B2_HUMAN (P48448)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ALDH3B2

# Metabolic_Enzyme_1_Geneatlas_id:
ALDH3B2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:411

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1158 bp
ATGAAGGATGAACCACGGTCCACGAACCTGTTCATGAAGCTGGACTCGGTCTTCATCTGG
AAGGAACCCTTTGGCCTGGTCCTCATCATCGCACCCTGGAACTACCCATTGAACCTGACC
CTGGTGCTCCTGGTGGGCACCCTCCCCGCAGGGAATTGCGTGGTGCTGAAGCCGTCAGAA
ATCAGCCAGGGCACAGAGAAGGTCCTGGCTGAGGTGCTGCCCCAGTACCTGGACCAGAGC
TGCTTTGCCGTGGTGCTGGGCGGACCCCAGGAGACAGGGCAGCTGCTAGAGCACAAGTTG
GACTACATCTTCTTCACAGGGAGCCCTCGTGTGGGCAAGATTGTCATGACTGCTGCCACC
AAGCACCTGACGCCTGTCACCCTGGAGCTGGGGGGCAAGAACCCCTGCTACGTGGACGAC
AACTGCGACCCCCAGACCGTGGCCAACCGCGTGGCCTGGTTCTGCTACTTCAATGCCGGC
CAGACCTGCGTGGCCCCTGACTACGTCCTGTGCAGCCCCGAGATGCAGGAGAGGCTGCTG
CCCGCCCTGCAGAGCACCATCACCCGTTTCTATGGCGACGACCCCCAGAGCTCCCCAAAC
CTGGGCCGCATCATCAACCAGAAACAGTTCCAGCGGCTGCGGGCATTGCTGGGCTGCGGC
CGCGTGGCCATTGGGGGCCAGAGCAACGAGAGCGATCGCTACATCGCCCCCACGGTGCTG
GTGGACGTGCAGGAGACGGAGCCTGTGATGCAGGAGGAGATCTTCGGGCCCATCCTGCCC
ATCGTGAACGTGCAGAGCGTGGACGAGGCCATCAAGTTCATCAACCGGCAGGAGAAGCCC
CTGGCCCTGTACGCCTTCTCCAACAGCAGACAGGTTGTGAACCAGATGCTGGAGCGGACC
AGCAGCGGCAGCTTTGGAGGCAATGAGGGCTTCACCTACATATCTCTGCTGTCCGTGCCA
TTCGGGGGAGTCGGCCACAGTGGGATGGGCCGGTACCACGGCAAGTTCACCTTCGACACC
TTCTCCCACCACCGCACCTGCCTGCTCGCCCCCTCCGGCCTGGAGAAATTAAAGGAGATC
CGCTACCCACCCTATACCGACTGGAACCAGCAGCTGTTACGCTGGGGCATGGGCTCCCAG
AGCTGCACCCTCCTGTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U37519

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_1_Locus:
11q13

# Metabolic_Enzyme_1_SNPs:
rs3741178; rs1551888; rs4646826; rs6591270; rs1551886; rs3741172; rs2279123; rs2279124; rs17510687; rs4313593; rs3127; rs1551885; rs3808972; rs2279125; rs1903829; rs866907; rs7947978; rs11823098; rs7114210; rs2514061; rs2251277; rs6591274; rs6591273; rs4646823; rs3825021; rs28372760; rs2279126; rs6591272; rs7947754; rs5019163; rs1871031; rs4930471; rs2514063; rs4569014; rs4930472; rs12295420; rs2251281; rs10791909; rs9787887; rs6591271; rs9736142; rs3741179; rs2514060; rs4930465; rs1551887; rs1871032; rs1979376; rs1979375; rs11603033; rs6591269; rs7934566; rs11821703; rs2514056; rs2514057; rs1140670; rs2447571; rs12292126; rs1131740; rs12278968; rs17856219; rs1051493; rs4646818; rs2514019; rs4587733; rs7483770; rs4646821; rs28887499; rs2447570; rs2514058; rs35431164; rs7944424; rs34589365; rs3191912; rs2514059; rs34763154; rs2514062; rs4930474; rs4646820; rs4581451; rs4646822; rs35843427; rs34926854; rs34057662; rs12361092; rs35632190; rs35691462; rs4646819; rs7483773; rs12288316; rs2447598; rs35605762; rs36154763; rs1131725; rs12272679; rs3928535; rs4930475; rs5019164; rs2447593; rs11227878; rs4646827; rs2126716; rs12285813; rs7943880; rs28819504; rs34264835; rs3741177; rs5792425; rs12807294; rs4244825; rs4646824; rs5792424; rs4646825; rs33990300; rs11826930; rs12574701; rs12294545; rs11824747; rs10736660; rs11828473; rs12272021; rs12288023; rs12363825; rs2054409; rs2447597; rs2509720; rs2514024; rs2514025; rs2885171; rs4930211; rs4930212; rs4930463; rs4930464; rs6591267; rs7108411

# Metabolic_Enzyme_1_General_References:
7484374; 8890755

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5529

# Metabolic_Enzyme_2_Name:
Aldehyde dehydrogenase 1A3

# Metabolic_Enzyme_2_Synonyms:
Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3

# Metabolic_Enzyme_2_Gene_Name:
ALDH1A3

# Metabolic_Enzyme_2_Protein_Sequence:
>Aldehyde dehydrogenase 1A3
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI
CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM
DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW
NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV
GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE
CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK
QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL
KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF
KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP

# Metabolic_Enzyme_2_Number_of_Residues:
512

# Metabolic_Enzyme_2_Molecular_Weight:
56109

# Metabolic_Enzyme_2_Theoretical_pI:
7.29

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system

# Metabolic_Enzyme_2_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_2_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
544482

# Metabolic_Enzyme_2_SwissProt_ID:
AL1A3_HUMAN (P47895)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ALDH1A3

# Metabolic_Enzyme_2_Geneatlas_id:
ALDH1A3

# Metabolic_Enzyme_2_hgnc_id:
HGNC:409

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1539 bp
ATGGCCACCGCTAACGGGGCCGTGGAAAACGGGCAGCCGGACGGGAAGCCGCCGGCCCTG
CCGCGCCCCATCCGCAACCTGGAGGTCAAGTTCACCAAGATATTTATCAACAATGAATGG
CACGAATCCAAGAGTGGGAAAAAGTTTGCTACATGTAACCCTTCAACTCGGGAGCAAATA
TGTGAAGTGGAAGAAGGAGATAAGCCCGACGTGGACAAGGCTGTGGAGGCTGCACAGGTT
GCCTTCCAGAGGGGCTCGCCATGGCGCCGGCTGGATGCCCTGAGTCGTGGGCGGCTGCTG
CACCAGCTGGCTGACCTGGTGGAGAGGGACCGCGCCACCTTGGCCGCCCTGGAGACGATG
GATACAGGGAAGCCATTTCTTCATGCTTTTTTCATCGACCTGGAGGGCTGTATTAGAACC
CTCAGATACTTTGCAGGGTGGGCAGACAAAATCCAGGGCAAGACCATCCCCACAGATGAC
AACGTCGTATGCTTCACCAGGCATGAGCCCATTGGTGTCTGTGGGGCCATCACTCCATGG
AACTTCCCCCTGCTGATGCTGGTGTGGAAGCTGGCACCCGCCCTCTGCTGTGGGAACACC
ATGGTCCTGAAGCCTGCGGAGCAGACACCTCTCACCGCCCTTTATCTCGGCTCTCTGATC
AAAGAGGCCGGGTTCCCTCCAGGAGTGGTGAACATTGTGCCAGGATTCGGGCCCACAGTG
GGAGCAGCAATTTCTTCTCACCCTCAGATCAACAAGATCGCCTTCACCGGCTCCACAGAG
GTTGGAAAACTGGTTAAAGAAGCTGCGTCCCGGAGCAATCTGAAGCGGGTGACGCTGGAG
CTGGGGGGGAAGAACCCCTGCATCGTGTGTGCGGACGCTGACTTGGACTTGGCAGTGGAG
TGTGCCCATCAGGGAGTGTTCTTCAACCAAGGCCAGTGTTGCACGGCAGCCTCCAGGGTG
TTCGTGGAGGAGCAGGTCTACTCTGAGTTTGTCAGGCGGAGCGTGGAGTATGCCAAGAAA
CGGCCCGTGGGAGACCCCTTCGATGTCAAAACAGAACAGGGGCCTCAGATTGATCAAAAG
CAGTTCGACAAAATCTTAGAGCTGATCGAGAGTGGGAAGAAGGAAGGGGCCAAGCTGGAA
TGCGGGGGCTCAGCCATGGAAGACAAGGGGCTCTTCATCAAACCCACTGTCTTCTCAGAA
GTCACAGACAACATGCGGATTGCCAAAGAGGAGATTTTCGGGCCAGTGCAACCAATACTG
AAGTTCAAAAGTATCGAAGAAGTGATAAAAAGAGCGAATAGCACCGACTATGGACTCACA
GCAGCCGTGTTCACAAAAAATCTCGACAAAGCCCTGAAGTTGGCTTCTGCCTTAGAGTCT
GGAACGGTCTGGATCAACTGCTACAACGCCCTCTATGCACAGGCTCCATTTGGTGGCTTT
AAAATGTCAGGAAATGGCAGAGAACTAGGTGAATACGCTTTGGCCGAATACACAGAAGTG
AAAACTGTCACCATCAAACTTGGCGACAAGAACCCCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
U07919

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_2_Locus:
15q26.3

# Metabolic_Enzyme_2_SNPs:
rs3803430; rs2229183; rs1130738; rs14226; rs3803424; rs7045; rs3803426; rs7182089; rs4646690; rs7161860; rs4246328; rs4646688; rs4646668; rs4646670; rs3803428; rs4646671; rs6598396; rs4646675; rs9944290; rs7181897; rs4646684; rs4246323; rs4246327; rs4246329; rs4646674; rs8039374; rs4646678; rs4646653; rs4646655; rs7182884; rs3809521; rs11854028; rs3825926; rs3803433; rs6598397; rs4646662; rs4646685; rs4646651; rs4646672; rs3922685; rs4646654; rs3902902; rs4646683; rs7176046; rs3803432; rs4246324; rs4646661; rs8030776; rs12903828; rs4646687; rs4646680; rs3825925; rs7178221; rs3803427; rs7170197; rs4246325; rs8023972; rs4646681; rs7167278; rs4246326; rs1886; rs4646649; rs12908902; rs7171776; rs3803429; rs12914598; rs4646669; rs4646650; rs3803434; rs4646660; rs4646682; rs3809524; rs3809523; rs3809526; rs7179268; rs1130737; rs3803431; rs1130768; rs34302490; rs28760343; rs35300460; rs1802602; rs1802604; rs4288979; rs3803425; rs1802603; rs4646663; rs28691047; rs28731371; rs34655770; rs35165034; rs28509297; rs10400871; rs35129664; rs12905372; rs28405557; rs34486175; rs28546254; rs35055541; rs4646686; rs28441320; rs28410143; rs4646676; rs4646648; rs8029933; rs12910188; rs34182689; rs28504296; rs28449981; rs28507582; rs3825927; rs35310246; rs12910025; rs28384196; rs4343265; rs12910662; rs8028283; rs28475530; rs4392045; rs28369514; rs28377287; rs8035722; rs28480133; rs28707102; rs28583888; rs4646666; rs7173413; rs28472416; rs28673034; rs28668881; rs28711429; rs34837038; rs4646659; rs28452487; rs28712665; rs12910029; rs12902704; rs4646673; rs28689536; rs28431101; rs34431941; rs7178645; rs28454526; rs7170202; rs1889; rs4646647; rs4375646; rs11348272; rs4646656; rs28408085; rs28699556; rs28615197; rs28539744; rs28557216; rs28631565; rs34302839; rs3923499; rs4646664; rs35740226; rs28385499; rs3922686; rs28474807; rs28490217; rs12909825; rs10593974; rs28679806; rs28610999; rs7178553; rs35519561; rs35831758; rs35526807; rs4646658; rs28538652; rs28685242; rs10400842; rs4646667; rs35948146; rs4646677; rs7165217; rs10400872; rs28750207; rs3825924; rs7171453; rs34906846; rs4646665; rs9920154; rs36081993; rs11435500; rs28464660; rs4646679; rs12595234; rs4646689; rs3809522; rs35950557; rs3809527; rs7172149; rs7178931; rs8034153; rs7183889; rs3809525; rs4646646; rs11630601; rs11630691; rs11632820; rs11637204; rs11854709; rs12148466; rs12148493; rs12440023; rs12593839; rs12901792; rs12907776; rs12908105; rs12909230; rs12909791; rs28507591; rs3803435; rs4346184; rs4646694; rs7163108; rs7164136; rs7181644; rs8034686; rs8035036

# Metabolic_Enzyme_2_General_References:
7698756

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5527

# Metabolic_Enzyme_3_Name:
Aldehyde dehydrogenase, dimeric NADP-preferring

# Metabolic_Enzyme_3_Synonyms:
ALDH class 3; ALDHIII

# Metabolic_Enzyme_3_Gene_Name:
ALDH3A1

# Metabolic_Enzyme_3_Protein_Sequence:
>Aldehyde dehydrogenase, dimeric NADPpreferring
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH

# Metabolic_Enzyme_3_Number_of_Residues:
453

# Metabolic_Enzyme_3_Molecular_Weight:
50380

# Metabolic_Enzyme_3_Theoretical_pI:
6.52

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes

# Metabolic_Enzyme_3_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_3_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_3_GenBank_ID_Protein:
178402

# Metabolic_Enzyme_3_SwissProt_ID:
AL3A1_HUMAN (P30838)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ALDH3A1

# Metabolic_Enzyme_3_Geneatlas_id:
ALDH3A1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:405

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>1362 bp
ATGAGCAAGATCAGCGAGGCCGTGAAGCGCGCCCGCGCCGCCTTCAGCTCGGGCAGGACC
CGTCCGCTGCAGTTCCGATTCCAGCAGCTGGAGGCGCTGCAGCGCCTGATCCAGGAGCAG
GAGCAGGAGCTGGTGGGCGCGCTGGCCGCAGACCTGCACAAGAATGAATGGAACGCCTAC
TATGAGGAGGTGGTGTACGTCCTAGAGGAGATCGAGTACATGATCCAGAAGCTCCCTGAG
TGGGCCGCGGATGAGCCCGTGGAGAAGACGCCCCAGACTCAGCAGGACGAGCTCTACATC
CACTCGGAGCCACTGGGCGTGGTCCTCGTCATTGGCACCTGGAACTACCCCTTCAACCTC
ACCATCCAGCCCATGGTGGGCGCCATCGCTGCAGGGAACGCAGTGGTCCTCAAGCCCTCG
GAGCTGAGTGAGAACATGGCGAGCCTGCTGGCTACCATCATCCCCCAGTACCTGGACAAG
GATCTGTACCCAGTAATCAATGGGGGTGTCCCTGAGACCACGGAGCTGCTCAAGGAGAGG
TTCGACCATATCCTGTACACGGGCAGCACGGGGGTGGGGAAGATCATCATGACGGCTGCT
GCCAAGCACCTGACCCCTGTCACGCTGGAGCTGGGAGGGAAGAGTCCCTGCTACGTGGAC
AAGAACTGTGACCTGGACGTGGCCTGCCGACGCATCGCCTGGGGGAAATTCATGAACAGT
GGCCAGACCTGCGTGGCCCCAGACTACATCCTCTGTGACCCCTCGATCCAGAACCAAATT
GTGGAGAAGCTCAAGAAGTCACTGAAAGAGTTCTACGGGGAAGATGCTAAGAAATCCCGG
GACTATGGAAGAATCATTAGTGCCCGGCACTTCCAGAGGGTGATGGGCCTGATTGAGGGC
CAGAAGGTGGCTTATGGGGGCACCGGGGATGCCGCCACTCGCTACATAGCCCCCACCATC
CTCACGGACGTGGACCCCCAGTCCCCGGTGATGCAAGAGGAGATCTTCGGGCCTGTGCTG
CCCATCGTGTGCGTGCGCAGCCTGGAGGAGGCCATCCAGTTCATCAACCAGCGTGAGAAG
CCCCTGGCCCTCTACATGTTCTCCAGCAACGACAAGGTGATTAAGAAGATGATTGCAGAG
ACATCCAGTGGTGGGGTGGCGGCCAACGATGTCATCGTCCACATCACCTTGCACTCTCTG
CCCTTCGGGGGCGTGGGGAACAGCGGCATGGGATCCTACCATGGCAAGAAGAGCTTCGAG
ACTTTCTCTCACCGCCGCTCTTGCCTGGTGAGGCCTCTGATGAATGATGAAGGCCTGAAG
GTCAGATACCCCCCGAGCCCGGCCAAGATGACCCAGCACTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M74542

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_3_Locus:
17p11.2

# Metabolic_Enzyme_3_SNPs:
rs887241; rs2228100; rs3744692; rs2072330; rs4646787; rs1042183; rs917520; rs4646789; rs4646788; rs3786036; rs887240; rs2072329; rs4646790; rs3744693; rs9895030; rs3826507; rs3744695; rs3744694; rs2072328; rs1006556; rs4319825; rs1042172; rs11554977; rs11554978; rs11554975; rs11554974; rs34474118; rs3786037; rs35473971; rs4646792; rs35116940; rs4646791; rs35853488; rs887239; rs28531080; rs7216299; rs35009373; rs3786035; rs11385990; rs35308039; rs35128135; rs35885485; rs28552545; rs34438543; rs1006553; rs11650088; rs11651480; rs11870332; rs12948881; rs12949049; rs12951039; rs16960382; rs16960386; rs17793620; rs1989379; rs2016823; rs2052052; rs2072327; rs2108967; rs3760485; rs3760486; rs3760487; rs4646783; rs4646784; rs4646785; rs4646786; rs4924793; rs4925046; rs7214841; rs7221211; rs7225305; rs8075157; rs9898715; rs9900430

# Metabolic_Enzyme_3_General_References:
1737758; 8493892; 2037078; 9250352

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5811

# Metabolic_Enzyme_4_Name:
Aldehyde dehydrogenase 3B1

# Metabolic_Enzyme_4_Synonyms:
Aldehyde dehydrogenase 7

# Metabolic_Enzyme_4_Gene_Name:
ALDH3B1

# Metabolic_Enzyme_4_Protein_Sequence:
>Aldehyde dehydrogenase 3B1
MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE
VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL
TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR
FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA
GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC
GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK
PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD
TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL

# Metabolic_Enzyme_4_Number_of_Residues:
468

# Metabolic_Enzyme_4_Molecular_Weight:
51840

# Metabolic_Enzyme_4_Theoretical_pI:
7.67

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

# Metabolic_Enzyme_4_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_4_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
601780

# Metabolic_Enzyme_4_SwissProt_ID:
AL3B1_HUMAN (P43353)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
ALDH3B1

# Metabolic_Enzyme_4_Geneatlas_id:
ALDH3B1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:410

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>1407 bp
ATGGACCCCCTTGGGGACACGCTGCGGCGACTGCGGGAGGCCTTCCACGCGGGGCGCACG
CGGCCAGCTGAGTTCCGGGCTGCGCAGCTCCAAGGCCTGGGCCGCTTCCTGCAAGAAAAC
AAGCAGCTTCTGCACGACGCACTGGCCCAGGACCTGCACAAGTCAGCCTTCGAGTCGGAG
GTGTCTGAGGTTGCCATCAGCCAGGGCGAGGTCACCCTGGCCCTCAGGAACCTCCGGGCC
TGGATGAAGGACGAGCGTGTGCCCAAGAACCTGGCCACGCAGCTGGACTCCGCCTTCATC
CGGAAGGAGCCCTTTGGCCTGGTCCTCATCATTGCGCCCTGGAACTATCCGCTGAACCTG
ACGCTGGTGCCCCTCGTGGGAGCCCTCGCTGCAGGGAACTGTGTGGTGCTGAAGCCATCG
GAGATTAGCAAGAACGTCGAGAAGATCCTGGCCGAGGTGCTGCCCCAATACGTGGACCAG
AGCTGCTTTGCTGTGGTGCTGGGCGGGCCCCAGGAGACGGGGCAGCTGCTAGAGCACAGG
TTCGACTACATCTTCTTCACAGGGAGCCCTCGTGTGGGCAAGATTGTTATGACTGCTGCC
GCCAAGCACCTGACACCTGTCACCCTGGAGCTGGGGGGCAAGAACCCTTGCTACGTGGAC
GACAACTGCGACCCCCAGACCGTGGCCAACCGCGTGGCCTGGTTCCGCTACTTCAACGCC
GGCCAGACCTGCGTGGCCCCCGACTACGTCCTATGCAGCCCTGAGATGCAGGAGAGGCTG
CTGCCTGCCCTGCAGAGCACCATCACCCGTTTCTATGGCGACGACCCCCAGAGCTCCCCA
AACCTGGGCCGCATCATCAACCAGAAACAGTTCCAGCGGCTGCGGGCATTGCTGGGCTGC
GGCCGTGTGGCCATTGGGGGCCAGAGCGATGAGAGCGATCGCTACATCGCCCCCACGGTG
CTGGTGGATGTGCAGGAGATGGAGCCTGTGATGCAGGAGGAGATCTTCGGGCCCATCCTG
CCCATCGTGAACGTGCAGAGCTTGGACGAGGCCATCGAGTTCATCAACCGGCGGGAGAAG
CCCCTGGCCCTGTACGCCTTCTCCAACAGCAGCCAGGTGGTCAAGCGGGTGCTGACCCAG
ACCAGCAGCGGGGGCTTCTGTGGGAACGACGGCTTCATGCACATGACCCTGGCCAGCCTG
CCTTTTGGAGGAGTGGGTGCCAGTGGGATGGGCCGGTACCATGGCAAGTTCTCCTTCGAC
ACCTTCTCCCACCATCGCGCCTGCCTCCTGCGCAGCCCGGGGATGGAGAAGCTCAACGCC
CTCCGCTACCCGCCGCAATCGCCGCGCCGCCTGAGGATGCTGCTGGTGGCCATGGAGGCC
CAAGGCTGCAGCTGCACACTGCTCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
U10868

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_4_Locus:
11q13

# Metabolic_Enzyme_4_SNPs:
rs572574; rs3764821; rs172620; rs3794181; rs3751081; rs12281209; rs1703440; rs3764818; rs556601; rs2286170; rs1003777; rs308293; rs2286169; rs4646809; rs3764819; rs886702; rs2286163; rs2286164; rs3794177; rs2286165; rs105147; rs2286168; rs2286166; rs308342; rs7125916; rs2286171; rs3794176; rs581105; rs12574760; rs3751082; rs308341; rs34280013; rs475325; rs3764817; rs3751084; rs4244839; rs4646812; rs598156; rs3764816; rs1636207; rs886701; rs11228121; rs308336; rs2010404; rs308335; rs557098; rs308334; rs308338; rs308337; rs3763941; rs737265; rs308333; rs35738719; rs12794336; rs34580830; rs11607185; rs1636208; rs1793238; rs1636209; rs11605214; rs7108283; rs3815220; rs12286110; rs34494820; rs35406834; rs2286167; rs12789057; rs33945294; rs7116695; rs35785905; rs11436139; rs28584816; rs12799330; rs4646808; rs5792429; rs4646813; rs12284146; rs12806003; rs4646811; rs34109111; rs35256233; rs34526809; rs12277180; rs4646810; rs177812; rs34271562; rs8181582; rs11433668; rs7925460; rs34588975; rs34721102; rs7116941; rs3794179; rs12273237; rs34130972; rs5792428; rs7113328; rs34928150; rs7117605; rs35400021; rs11826595; rs1051806; rs1076558; rs10896288; rs1122731; rs11228120; rs11228122; rs11823975; rs11824781; rs11825872; rs12418774; rs12421254; rs12803743; rs1703438; rs1804688; rs191064; rs191065; rs2075626; rs2286172; rs28939679; rs308326; rs308339; rs308340; rs3115545; rs3115546; rs3115548; rs3133266; rs3133267; rs3133269; rs3751085; rs3763942; rs3808969; rs3808970; rs3808971; rs4147776; rs4147777; rs4147778; rs4147780; rs4147782; rs479763; rs7949541; rs7951010; rs7952122; rs884826; rs999571

# Metabolic_Enzyme_4_General_References:
7828891

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5514

# Metabolic_Enzyme_5_Name:
Myeloperoxidase precursor

# Metabolic_Enzyme_5_Synonyms:
MPO[Contains: 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain]

# Metabolic_Enzyme_5_Gene_Name:
MPO

# Metabolic_Enzyme_5_Protein_Sequence:
>Myeloperoxidase precursor
MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS
LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH
VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC
NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD
QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND
PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL
GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL
REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR
SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE
GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN
AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL
LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS
NSYPRDFVNCSTLPALNLASWREAS

# Metabolic_Enzyme_5_Number_of_Residues:
745

# Metabolic_Enzyme_5_Molecular_Weight:
83870

# Metabolic_Enzyme_5_Theoretical_pI:
9.14

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity

# Metabolic_Enzyme_5_Pathway:
map00360  Phenylalanine metabolism;
 map00590  Prostaglandin and leukotriene metabolism;
 map00680  Methane metabolism;
 map00940  Stilbene, coumarine and lignin biosynthesis

# Metabolic_Enzyme_5_Reaction:
donor + H2O2 = oxidized donor + 2 H2O

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF03098:An_peroxidase

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.11.1.7

# Metabolic_Enzyme_5_GenBank_ID_Protein:
189040

# Metabolic_Enzyme_5_SwissProt_ID:
PERM_HUMAN (P05164)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
MPO

# Metabolic_Enzyme_5_Geneatlas_id:
MPO

# Metabolic_Enzyme_5_hgnc_id:
HGNC:7218

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_5_Gene_Sequence:
>2238 bp
ATGGGGGTTCCCTTCTTCTCTTCTCTCAGATGCATGGTGGACTTAGGACCTTGCTGGGCT
GGGGGTCTCACTGCAGAGATGAAGCTGCTTCTGGCCCTAGCAGGGCTCCTGGCCATTCTG
GCCACGCCCCAGCCCTCTGAAGGTGCTGCTCCAGCTGTCCTGGGGGAGGTGGACACCTCG
TTGGTGCTGAGCTCCATGGAGGAGGCCAAGCAGCTGGTGGACAAGGCCTACAAGGAGCGG
CGGGAAAGCATCAAGCAGCGGCTTCGCAGCGGCTCAGCCAGCCCCATGGAACTCCTATCC
TACTTCAAGCAGCCGGTGGCAGCCACCAGGACGGCGGTGAGGGCCGCTGACTACCTGCAC
GTGGCTCTAGACCTGCTGGAGAGGAAGCTGCGGTCCCTGTGGCGAAGGCCATTCAATGTC
ACTGATGTGCTGACGCCCGCCCAGCTGAATGTGTTGTCCAAGTCAAGCGGCTGCGCCTAC
CAGGACGTGGGGGTGACTTGCCCGGAGCAGGACAAATACCGCACCATCACCGGGATGTGC
AACAACAGACGCAGCCCCACGCTGGGGGCCTCCAACCGTGCCTTTGTGCGCTGGCTGCCG
GCGGAGTATGAGGACGGCTTCTCTCTTCCCTACGGCTGGACGCCCGGGGTCAAGCGCAAC
GGCTTCCCGGTGGCTCTGGCTCGCGCGGTCTCCAACGAGATCGTGCGCTTCCCCACTGAT
CAGCTGACTCCGGACCAGGAGCGCTCACTCATGTTCATGCAATGGGGCCAGCTGTTGGAC
CACGACCTCGACTTCACCCCTGAGCCGGCCGCCCGGGCCTCCTTCGTCACTGGCGTCAAC
TGCGAGACCAGCTGCGTTCAGCAGCCGCCCTGCTTCCCGCTCAAGATCCCGCCCAATGAC
CCCCGCATCAAGAACCAAGCCGACTGCATCCCGTTCTTCCGCTCCTGCCCGGCTTGCCCC
GGGAGCAACATCACCATCCGCAACCAGATCAACGCGCTCACTTCCTTCGTGGACGCCAGC
ATGGTGTACGGCAGCGAGGAGCCCCTGGCCAGGAACCTGCGCAACATGTCCAACCAGCTG
GGGCTGCTGGCCGTCAACCAGCGCTTCCAAGACAACGGCCGGGCCCTGCTGCCCTTTGAC
AACCTGCACGATGACCCCTGTCTCCTCACCAACCGCTCAGCGCGCATCCCCTGCTTCCTG
GCAGGGGACACCCGTTCCAGTGAGATGCCCGAGCTCACCTCCATGCACACCCTCTTACTT
CGGGAGCACAACCGGCTGGCCACAGAGCTCAAGAGCCTGAACCCTAGGTGGGATGGGGAG
AGGCTCTACCAGGAAGCCCGGAAGATCGTGGGGGCCATGGTCCAGATCATCACTTACCGG
GACTACCTGCCCCTGGTGCTGGGGCCAACGGCCATGAGGAAGTACCTGCCCACGTACCGT
TCCTACAATGACTCAGTGGACCCACGCATCGCCAACGTCTTCACCAATGCCTTCCGCTAC
GGCCACACCCTCATCCAACCCTTCATGTTCCGCCTGGACAATCGGTACCAGCCCATGGAA
CCCAACCCCCGTGTCCCCCTCAGCAGGGTCTTTTTTGCCTCCTGGAGGGTCGTGCTGGAA
GGTGGCATTGACCCCATCCTCCGGGGCCTCATGGCCACCCCTGCCAAGCTGAATCGTCAG
AACCAAATTGCAGTGGATGAGATCCGGGAGCGATTGTTTGAGCAGGTCATGAGGATTGGG
CTGGACCTGCCTGCTCTGAACATGCAGCGCAGCAGGGACCACGGCCTCCCAGGATACAAT
GCCTGGAGGCGCTTCTGTGGGCTCCCGCAGCCTGAAACTGTGGGCCAGCTGGGCACGGTG
CTGAGGAACCTGAAATTGGCGAGGAAACTGATGGAGCAGTATGGCACGCCCAACAACATC
GACATCTGGATGGGCGGCGTGTCCGAGCCTCTGAAGCGCAAAGGCCGCGTGGGCCCACTC
CTCGCCTGCATCATCGGTACCCAGTTCAGGAAGCTCCGGGATGGTGATCGGTTTTGGTGG
GAGAACGAGGGTGTGTTCAGCATGCAGCAGCGACAGGCCCTGGCCCAGATCTCATTGCCC
CGGATCATCTGCGACAACACAGGCATCACCACCGTGTCTAAGAACAACATCTTCATGTCC
AACTCATATCCCCGGGACTTTGTCAACTGCAGTACACTTCCTGCATTGAACCTGGCTTCC
TGGAGGGAAGCCTCCTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
J02694

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_5_Locus:
17q23.1

# Metabolic_Enzyme_5_SNPs:
rs7208693; rs2759; rs28730835; rs35314437; rs34628871; rs6503857; rs2856857; rs28396732; rs2071409; rs8067377; rs8082134; rs34506259; rs34704261; rs35921530; rs35840794; rs34028830; rs35087219; rs34376256; rs34212101; rs35400724; rs35112109; rs11575868; rs34471705; rs34914394; rs34673822; rs11649901; rs916115; rs35709273; rs7220117; rs8079006; rs2243828; rs2107545; rs2243827; rs8178426; rs2333227; rs12601419; rs34539862; rs34070619; rs34097845; rs34565045; rs8178428; rs35702888; rs35670089; rs2856856; rs28730837; rs35755750; rs2856855; rs35897051; rs35352616; rs8073898; rs11555567; rs34738107; rs11575867; rs2856859; rs2856858; rs2526363; rs11489012; rs2526362; rs2856852; rs34108145; rs28730838; rs11489013; rs2526364; rs12939070; rs34646152; rs12939069; rs11659055; rs34496983; rs36015586; rs35966215; rs35550002; rs36000892; rs35977697; rs2856864; rs34802326; rs8081735; rs2856861; rs11272526; rs34685535; rs2107546; rs34151601; rs36049426; rs916116; rs2526366; rs34341256; rs35614168; rs2856863; rs2856860; rs2526365; rs35830722; rs35286509; rs34841676; rs2856865; rs35922881; rs35369873; rs34432014; rs34576380; rs8178425; rs35412618; rs35433825; rs34240282; rs916114; rs34534274; rs2856854; rs34721594; rs35619750; rs8178429; rs2856853; rs8178424; rs8178427; rs34626646; rs11650865; rs12452417; rs12453852; rs12949848; rs16942910; rs2856862; rs34853811; rs3744104; rs4401102; rs8178373; rs8178375; rs8178378; rs8178380; rs8178381; rs8178384; rs8178386; rs8178387; rs8178392; rs8178395; rs8178398; rs8178404; rs8178405; rs8178406; rs8178407; rs8178409; rs8178410; rs8178412; rs8178415; rs8178416; rs8178417; rs8178418

# Metabolic_Enzyme_5_General_References:
3029127; 2444596; 3031585; 2552418; 3654979; 2903767; 8383257; 8390465; 2884926; 2154223; 10766826; 7840679; 11705390; 8142659; 7904599; 8621627; 9637725; 9354683

# Metabolic_Enzyme_5_References:
11054430; 9065416

End of HMDB00020

Beginning of HMDB00021
# Accession_No:
HMDB00021

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-07-16 11:27:57

# biospider_lastupdate:
2007-07-24 17:06:08

# Common_Name:
Iodotyrosine

# Description:
An iodated derivative of L-tyrosine.  This is an early precursor to L-thyroxine, one of the primary thyroid hormones.  In the thyroid gland, iodide is trapped, transported, and concentrated in the follicular lumen for thyroid hormone synthesis. Before trapped iodide can react with tyrosine residues, it must be oxidized by thyroid peroxidase.  Iodotyrosine is made from tyrosine via thyroid peroxidase and then further iodinated by this enzyme to make the di-iodo and tri-iodo variants.    Two molecules of di-iodotyrosine combine to form T4, and one molecule of mono-iodotyrosine combines with one molecule of di-iodotyrosine to form T3.

# Synonyms:
Monoiodotyrosine; 3-Iodo-L-tyrosine; MIT; 3-Monoiodo-L-tyrosine; 3-Iodotyrosine; 3-Iodo-4-hydroxyphenylalanine; IYR; 3-iodo-tyrosine; (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid; 4-Hydroxy-3-iodophenylalanine; L-Tyrosine-3-iodo

# Chemical_IUPAC_Name:
(2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid

# Chemical_Formula:
C9H10INO3

# Chemical_Structure:
tbl_chemical:::HMDB00021_ZOOM.png:::119283133833215950

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00021_THUMB.png:::119283133639499691

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
alpha-aminoacid; carboxylic acid; aromatic compound; primary amine; aryl iodide; primary aliphatic amine (alkylamine); phenol or hydroxyhetarene

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
306.97052

# Molecular_Weight_Avg:
307.08508

# Smiles_String_isomeric:
N[C@@H](CC1=CC=C(O)C(I)=C1)C(O)=O

# Smiles_String_canonical:
NC(CC1=CC=C(O)C(I)=C1)C(O)=O

# KEGG_Compound_ID:
C02515

# BioCyc_ID:
IODO-L-TYROSINE

# PubChem_CID:
439744

# PubChem_SID:
7888504; 8144448; 24278154; 855708; 3133565; 17405234; 7979635; 585618; 5525; 10298449; 16147179

# OMIM_ID:
274800

# Metagene_ID:
Not Available

# BiGG_ID:
39998

# Wikipedia_ID:
Not Available

# METLIN_ID:
Not Available

# Ref_ID:
12409460; 108034; 838849; 1127080; 6133737; 12013218

# ChEBI_ID:
27847

# CAS_Registry_Number:
70-78-0

# InChI:
InChI=1/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1

# Synthesis_Reference:
 Chemical Engineering Research and Design  (1983),  61(5),  297-302.

# Melting_Point:
205 oC

# Melting_Point_predicted:
113.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
3 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
124.0 mg/mL [MEYLAN,WM et al. (1996)]; 0.937 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-0.7 [Predicted by PubChem via XLOGP]; -1.50 [Predicted by ALOGPS]; -0.60 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C02515.mol:::1132723801750493913

# SDF_File_[Text]:
tbl_chemical:::HMDB00021.sdf:::119283133287953100

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00021.pdb:::119283133471450116

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041112_01_PO_1DP_presat.png:::114850386824314889

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041112_P00_01_HW_1DP_PRESAT_1.zip:::1141683750443165

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041112_P00_01_HW_1DP_Assigned.png:::115628337230117484

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041112_P00_01_HW_2DHSQC_894.png:::11480567096163208

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041112_P00_01_HW_2DHSQC_894.zip:::11480567096236374

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041112_P00_01_HW_2DHSQC_894_Assigned.png:::116180693848325175

# Predicted_H_NMR_Spectrum:
tbl_chemical:::3-Iodo-L-Tyrosine.gif:::11327320993127718

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00021_peaks.txt:::1156309490398286963

# Predicted_C_NMR_Spectrum:
tbl_chemical:::3-Iodo-L-Tyrosine_C.gif:::1132737658278857556

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00021_peaks.txt:::1156310682305210537

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00021L.png:::117555261789516917; Medium Energy:tbl_ms:::HMDB00021M.png:::117555266899279535; High Energy:tbl_ms:::HMDB00021H.png:::117555270743442367

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Thyroid Gland

# deuterated:
No

# Biofluid_Location:
Blood

# Concentration_[Normal]:
Not Available


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Congenital Hypothyroidism; Deiodinase Deficiency; Iodotyrosine Dehalogenase Deficiency

# Pathway_Names:
Tyrosine metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00350

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5508

# Metabolic_Enzyme_1_Name:
Thyroid peroxidase precursor

# Metabolic_Enzyme_1_Synonyms:
TPO

# Metabolic_Enzyme_1_Gene_Name:
TPO

# Metabolic_Enzyme_1_Protein_Sequence:
>Thyroid peroxidase precursor
MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR
NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS
EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV
YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD
IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD
QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG
RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA
LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT
VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIR
GLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGL
PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ
MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES
CDSIPGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL
TCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD
SGRLPRATWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ
AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL

# Metabolic_Enzyme_1_Number_of_Residues:
933

# Metabolic_Enzyme_1_Molecular_Weight:
102932

# Metabolic_Enzyme_1_Theoretical_pI:
6.75

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4)

# Metabolic_Enzyme_1_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_1_Reaction:
iodide + H2O2 = iodine + 2 H2O

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF03098:An_peroxidase;
PF07645:EGF_CA;
PF00084:Sushi

# Metabolic_Enzyme_1_Signals:
1-14

# Metabolic_Enzyme_1_Transmembrane_Regions:
847-871

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.11.1.8

# Metabolic_Enzyme_1_GenBank_ID_Protein:
339867

# Metabolic_Enzyme_1_SwissProt_ID:
PERT_HUMAN (P07202)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
TPO

# Metabolic_Enzyme_1_Geneatlas_id:
TPO

# Metabolic_Enzyme_1_hgnc_id:
HGNC:12015

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Metabolic_Enzyme_1_Gene_Sequence:
>2802 bp
ATGAGAGCGCTCGCTGTGCTGTCTGTCACGCTGGTTATGGCCTGCACAGAAGCCTTCTTC
CCCTTCATCTCGAGAGGGAAAGAACTCCTTTGGGGAAAGCCTGAGGAGTCTCGTGTCTCT
AGCGTCTTGGAGGAAAGCAAGCGCCTGGTGGACACCGCCATGTACGCCACGATGCAGAGA
AACCTCAAGAAAAGAGGAATCCTTTCTCCAGCTCAGCTTCTGTCTTTTTCCAAACTTCCT
GAGCCAACAAGCGGAGTGATTGCCCGAGCAGCAGAGATAATGGAAACATCAATACAAGCG
ATGAAAAGAAAAGTCAACCTGAAAACTCAACAATCACAGCATCCAACGGATGCTTTATCA
GAAGATCTGCTGAGCATCATTGCAAACATGTCTGGATGTCTCCCTTACATGCTGCCCCCA
AAATGCCCAAACACTTGCCTGGCGAACAAATACAGGCCCATCACAGGAGCTTGCAACAAC
AGAGACCACCCCAGATGGGGCGCCTCCAACACGGCCCTGGCACGATGGCTCCCTCCAGTC
TATGAGGACGGCTTCAGTCAGCCCCGAGGCTGGAACCCCGGCTTCTTGTACAACGGGTTC
CCACTGCCCCCGGTCCGGGAGGTGACAAGACATGTCATTCAAGTTTCAAATGAGGTTGTC
ACAGATGATGACCGCTATTCTGACCTCCTGATGGCATGGGGACAATACATCGACCACGAC
ATCGCGTTCACACCACAGAGCACCAGCAAAGCTGCCTTCGGGGGAGGGGCTGACTGCCAG
ATGACTTGTGAGAACCAAAACCCATGTTTTCCCATACAACTCCCGGAGGAGGCCCGGCCG
GCCGCGGGCACCGCCTGTCTGCCCTTCTACCGCTCTTCGGCCGCCTGCGGCACCGGGGAC
CAAGGCGCGCTCTTTGGGAACCTGTCCACGGCCAACCCGCGGCAGCAGATGAACGGGTTG
ACCTCGTTCCTGGACGCGTCCACCGTGTATGGCAGCTCCCCGGCCCTAGAGAGGCAGCTG
CGGAACTGGACCAGTGCCGAAGGGCTGCTCCGCGTCCACGCGCGCCTCCGGGACTCCGGC
CGCGCCTACCTGCCCTTCGTGCCGCCACGGCGGCCTGCGGCCTGTGCGCCCGAGCCCGGC
ATCCCCGGAGAGACCCGCGGGCCCTGCTTCCTGGCCGGAGACGGCCGCGCCAGCGAGGTC
CCCTCCCTGACGGCACTGCACACGCTGTGGCTGCGCGAGCACAACCGCCTGGCCGCGGCG
CTCAAGGCCCTCAATGCGCACTGGAGCGCGGACGCCGTGTACCAGGAGGCGCGCAAGGTC
GTGGGCGCTCTGCACCAGATCATCACCCTGAGGGATTACATCCCCAGGATCCTGGGACCC
GAGGCCTTCCAGCAGTACGTGGGTCCCTATGAAGGCTATGACTCCACCGCCAACCCCACT
GTGTCCAACGTGTTCTCCACAGCCGCCTTCCGCTTCGGCCATGCCACGATCCACCCGCTG
GTGAGGAGGCTGGACGCCAGCTTCCAGGAGCACCCCGACCTGCCCGGGCTGTGGCTGCAC
CAGGCTTTCTTCAGCCCATGGACATTACTCCGTGGAGGTGGTTTGGACCCACTAATACGA
GGCCTTCTTGCAAGACCAGCCAAACTGCAGGTGCAGGATCAGCTGATGAACGAGGAGCTG
ACGGAAAGGCTCTTTGTGCTGTCCAATTCCAGCACCTTGGATCTGGCGTCCATCAACCTG
CAGAGGGGCCGGGACCACGGGCTGCCAGGTTACAATGAGTGGAGGGAGTTCTGCGGCCTG
CCTCGCCTGGAGACCCCCGCTGACCTGAGCACAGCCATCGCCAGCAGGAGCGTGGCCGAC
AAGATCCTGGACTTGTACAAGCATCCTGACAACATCGATGTCTGGCTGGGAGGCTTAGCT
GAAAACTTCCTCCCCAGGGCTCGGACAGGGCCCCTGTTTGCCTGTCTCATTGGGAAGCAG
ATGAAGGCTCTGCGGGATGGTGACTGGTTTTGGTGGGAGAACAGCCACGTCTTCACGGAT
GCACAGAGGCGTGAGCTGGAGAAGCACTCCCTGTCTCGGGTCATCTGTGACAACACTGGC
CTCACCAGGGTGCCCATGGATGCCTTCCAAGTCGGCAAATTCCCTGAAGACTTTGAGTCT
TGTGACAGCATCCCTGGCATGAACCTGGAGGCCTGGAGGGAAACCTTTCCTCAAGACGAC
AAGTGTGGCTTCCCAGAGAGCGTGGAGAATGGGGACTTTGTGCACTGTGAGGAGTCTGGG
AGGCGCGTGCTGGTGTATTCCTGCCGGCACGGGTATGAGCTCCAAGGCCGGGAGCAGCTC
ACTTGCACCCAGGAAGGATGGGATTTCCAGCCTCCCCTCTGCAAAGATGTGAACGAGTGT
GCAGACGGTGCCCACCCCCCCTGCCACGCCTCTGCGAGGTGCAGAAACACCAAAGGCGGC
TTCCAGTGTCTCTGCGCGGACCCCTACGAGTTAGGAGACGATGGGAGAACCTGCGTAGAC
TCCGGGAGGCTCCCTCGGGCGACTTGGATCTCCATGTCGCTGGCTGCTCTGCTGATCGGA
GGCTTCGCAGGTCTCACCTCGACGGTGATTTGCAGGTGGACACGCACTGGCACTAAATCC
ACACTGCCCATCTCGGAGACAGGCGGAGGAACTCCCGAGCTGAGATGCGGAAAGCACCAG
GCCGTAGGGACCTCACCGCAGCGGGCCGCAGCTCAGGACTCGGAGCAGGAGAGTGCTGGG
ATGGAAGGCCGGGATACTCACAGGCTGCCGAGAGCCCTCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
J02969

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_1_Locus:
2p25

# Metabolic_Enzyme_1_SNPs:
rs2175977; rs13431173; rs732609; rs4927611; rs1126799; rs10189135; rs1042589; rs2280132; rs28915688; rs28991293; rs28913014; rs732608; rs13429240; rs17091745; rs28915689; rs28909989; rs28910597; rs9678281; rs17415659; rs2071403; rs9326166; rs9326167; rs17091628; rs28909986; rs28909987; rs2009364; rs1464083; rs1514686; rs1464086; rs2048726; rs2048722; rs961028; rs1965406; rs2048721; rs1514682; rs1877854; rs6715129; rs7602540; rs949835; rs938330; rs9679017; rs6706775; rs9751670; rs10198697; rs1399390; rs11211650; rs2070878; rs13424221; rs1399387; rs10172186; rs10206727; rs11694817; rs3755554; rs6588672; rs10165715; rs10208730; rs9326170; rs4927624; rs4927612; rs2070879; rs4278970; rs4927619; rs13430369; rs13413321; rs2276702; rs6716111; rs2175978; rs10204647; rs1877855; rs7583792; rs6717381; rs4927615; rs2280129; rs7598233; rs6711545; rs11891272; rs13425669; rs11886972; rs7596885; rs6716250; rs11211651; rs6732480; rs9679267; rs6747390; rs6588665; rs867983; rs9326169; rs11896517; rs1464085; rs11888851; rs6708496; rs7602332; rs10170919; rs2361754; rs1464084; rs6714887; rs6759960; rs1514688; rs2090154; rs1913584; rs6708273; rs10204515; rs3755555; rs11888196; rs10201842; rs6711901; rs938327; rs2138018; rs1567918; rs6760043; rs10171105; rs2138019; rs4927610; rs6752121; rs10205811; rs11211654; rs6740728; rs10189329; rs6727192; rs2070881; rs1965405; rs6588664; rs1473936; rs10177597; rs11897437; rs1967512; rs2885361; rs2361748; rs4927631; rs1514687; rs11690515; rs11904276; rs950675; rs6588669; rs10169429; rs4927621; rs11896057; rs6588674; rs11691841; rs6588673; rs10197874; rs9678469; rs9751407; rs4927608; rs2014911; rs6723319; rs1399389; rs4927580; rs10205420; rs11897713; rs2885362; rs11211653; rs2070882; rs9750182; rs6588663; rs12615819; rs4927578; rs10174000; rs13386909; rs6754104; rs17732233; rs6718027; rs11891867; rs13393765; rs11211649; rs10193983; rs13398180; rs4927574; rs11687944; rs9973690; rs2280131; rs7574221; rs12465127; rs11675388; rs10200413; rs10167570; rs13412229; rs6588676; rs13429459; rs3755549; rs12328748; rs13427125; rs28361468; rs9326171; rs3834179; rs3755548; rs4359704; rs2361767; rs10188260; rs11694726; rs17091772; rs10165832; rs949834; rs11674560; rs4927581; rs7424680; rs3796122; rs13412980; rs17731349; rs9677050; rs4927606; rs13431646; rs13415674; rs949833; rs4927593; rs4927585; rs4600709; rs1514685; rs4328675; rs4927591; rs17731324; rs4425120; rs11899801; rs10495482; rs4927589; rs2070877; rs4927632; rs2070880; rs2048727; rs2276701; rs12619427; rs13431898; rs3755550; rs10519477; rs12472829; rs6588671; rs10170270; rs13405352; rs1976692; rs10189437; rs3772076; rs3772075; rs6588667; rs11683914; rs11211647; rs4481033; rs13431282; rs2276704; rs11691963; rs11891228; rs10166929; rs2280128; rs10190245; rs6588675; rs4927590; rs13414566; rs2361750; rs10196514; rs1514684; rs4592894; rs3772074; rs4927579; rs28663288; rs6588670; rs11211652; rs7355479; rs11692536; rs13409391; rs12470856; rs3755551; rs10181072; rs11691145; rs13405477; rs17091682; rs11682961; rs6712430; rs11897718; rs10194040; rs10207656; rs11681087; rs11211646; rs17091633; rs13400150; rs4927575; rs949832; rs1969248; rs17091667; rs13418264; rs7564759; rs1818525; rs13392535; rs11689536; rs11896906; rs17091737; rs3755553; rs3755552; rs12478431; rs4927617; rs6751783; rs9326172; rs1514683; rs11887707; rs938328; rs6588678; rs17091744; rs2048724; rs11211655; rs2007268; rs28913037; rs28909998; rs13409815; rs10890518; rs28910600; rs28912368; rs11886764; rs28913007; rs28910585; rs28912975; rs28910579; rs7607582; rs28912989; rs9326168; rs28911496; rs28991288; rs28913033; rs28910603; rs28910595; rs28915678; rs28909396; rs28909371; rs9798488; rs28912994; rs11904640; rs12616671; rs28911471; rs28909384; rs28913016; rs28991294; rs28912972; rs13016763; rs12471358; rs28991276; rs28909999; rs13422969; rs11675177; rs28911488; rs28909393; rs28915676; rs28912991; rs4927607; rs28910607; rs6588668; rs4927614; rs12471599; rs11685779; rs28910000; rs28913029; rs28909401; rs28910568; rs28991269; rs28912974; rs11686432; rs11674407; rs28910591; rs28991283; rs4927586; rs28913003; rs2361744; rs2138020; rs4927592; rs28991290; rs28915672; rs28909379; rs28909400; rs29001651; rs28911495; rs28911485; rs28909994; rs28909372; rs28911492; rs4927594; rs28910575; rs10181280; rs28911481; rs11695695; rs28910578; rs28913271; rs28909415; rs4927622; rs28909397; rs28913022; rs11678545; rs28909390; rs28911170; rs28910007; rs11899018; rs28915677; rs28910594; rs28911470; rs9677934; rs12328533; rs28915670; rs28991273; rs17732056; rs28911475; rs28913008; rs9677308; rs28910586; rs28910606; rs28909380; rs28912992; rs28909402; rs28910574; rs9678767; rs6711500; rs28911487; rs28913023; rs28915684; rs4927577; rs13391992; rs28909411; rs11211648; rs11685540; rs28913275; rs28912969; rs28913030; rs28915673; rs28991277; rs28909407; rs28909387; rs28909993; rs28911480; rs4567992; rs28911171; rs13394978; rs28911493; rs28913041; rs11885587; rs28910583; rs28913270; rs28912999; rs2138017; rs10197546; rs28991289; rs4927628; rs9678341; rs28913004; rs28911478; rs28910013; rs28912996; rs10205550; rs28910599; rs13391557; rs28909391; rs28915680; rs4927582; rs4927625; rs17731501; rs13409953; rs11676827; rs13418570; rs11683140; rs9677680; rs13394194; rs28913013; rs28912985; rs11889947; rs28912981; rs1113829; rs4927584; rs10207591; rs28912980; rs2048725; rs28913274; rs4927613; rs28991274; rs28913011; rs28910005; rs28910002; rs9678972; rs13016765; rs17091706; rs28909403; rs28991281; rs28910605; rs28909383; rs28913273; rs28913017; rs28913024; rs13410529; rs7591179; rs28910611; rs28909394; rs28915685; rs28910580; rs11899974; rs12468041; rs11690402; rs28909368; rs28915674; rs28909373; rs28912998; rs28913009; rs28913039; rs28911175; rs28913035; rs17091666; rs28911490; rs28991270; rs28910577; rs28909992; rs28910001; rs28911172; rs28912984; rs4927588; rs28910571; rs28910010; rs4425119; rs28909389; rs28913028; rs13399844; rs4314036; rs12621034; rs4927609; rs28915668; rs4645041; rs13426289; rs4927616; rs28910609; rs28912988; rs28913040; rs11687912; rs28991285; rs28910573; rs28910584; rs28913020; rs28911476; rs28910602; rs28913005; rs6588666; rs11676091; rs28913031; rs10204402; rs28913001; rs28909668; rs28911483; rs28911473; rs28909374; rs28911468; rs13430623; rs28909386; rs28991271; rs28909382; rs28913021; rs12328004; rs28910576; rs11695385; rs1965407; rs28910601; rs28909990; rs4629198; rs28912993; rs10193135; rs28913010; rs28911173; rs28912977; rs7568087; rs28910014; rs1828865; rs12718450; rs28911491; rs11674711; rs28911168; rs4927587; rs28909991; rs28910581; rs28910610; rs28909395; rs4927583; rs28913018; rs1567919; rs28912971; rs28913036; rs28991275; rs28913042; rs28915675; rs28991287; rs28910588; rs28991278; rs961029; rs28912990; rs28913019; rs1567917; rs28910608; rs28909408; rs28912987; rs28909375; rs28915669; rs28912970; rs28909385; rs7597945; rs28991272; rs28913269; rs11676046; rs28909392; rs28909414; rs28909388; rs28910011; rs28912983; rs12105374; rs28991279; rs4404322; rs28915671; rs28911482; rs12613496; rs13431561; rs4927630; rs28913272; rs28912973; rs28911469; rs28911472; rs28909399; rs28913006; rs28911494; rs28910572; rs11690812; rs13415386; rs2071399; rs2280126; rs2298876; rs2071402; rs2071401; rs4927604; rs2280127; rs2071400; rs28991568; rs28915690; rs28909983; rs2298875; rs28910612; rs28991292; rs17855780; rs28915687; rs28910598; rs3732349; rs35105246; rs13407655; rs28909988; rs28915683; rs10536458; rs35505969; rs12474694; rs6755275; rs10180652; rs12993998; rs33961599; rs28909381; rs28360867; rs4927627; rs11681539; rs13410524; rs13383329; rs28912968; rs13415459; rs9973956; rs35756267; rs28909376; rs35523187; rs2048723; rs28630635; rs13031189; rs28911174; rs28633865; rs28909410; rs10629723; rs28909378; rs11677995; rs34132009; rs13413324; rs28911474; rs28910590; rs12994019; rs34920078; rs13000154; rs13000160; rs35605249; rs10166153; rs35043612; rs10666298; rs13026152; rs2885358; rs33990262; rs28910604; rs28910582; rs11688703; rs34374057; rs28912978; rs10176490; rs28915686; rs34413546; rs28632119; rs35225495; rs13430142; rs35431867; rs12987712; rs28460424; rs35944967; rs10184056; rs35732856; rs35531860; rs36119335; rs13396955; rs28909406; rs13020227; rs10203030; rs12612745; rs11689344; rs28912982; rs10206512; rs28912986; rs7369446; rs11686894; rs28909997; rs12986996; rs11691839; rs13035669; rs28580848; rs13006856; rs13385085; rs13415301; rs3831487; rs10190227; rs11686114; rs28912995; rs12616672; rs11412726; rs28915679; rs35725026; rs28672357; rs35893094; rs28910012; rs12476324; rs10608158; rs28874626; rs28909369; rs28464331; rs28445930; rs12986956; rs28913038; rs28991280; rs34191654; rs28665837; rs12478638; rs1399391; rs11688366; rs13006647; rs28910003; rs13036149; rs6705010; rs28671559; rs35708755; rs2280130; rs13410383; rs13393048; rs28909412; rs13430024; rs28912979; rs13382606; rs10193732; rs10573336; rs34043302; rs9677153; rs35874586; rs13382789; rs28437604; rs11678127; rs13430374; rs36220342; rs13397445; rs35553172; rs34128932; rs28911484; rs28991284; rs13431558; rs11687959; rs12105080; rs28991268; rs13027675; rs13000139; rs28651176; rs11687787; rs35908928; rs10208039; rs28913000; rs28729219; rs28566655; rs10194736; rs13026377; rs10666299; rs13420584; rs28910006; rs9677433; rs13424741; rs10184419; rs34359520; rs35103896; rs34099200; rs28909996; rs28433376; rs11904785; rs5828821; rs28909377; rs12612565; rs11272722; rs13392954; rs35752553; rs35208164; rs28378083; rs34080455; rs28913012; rs28636451; rs11272011; rs12992674; rs11412725; rs28435455; rs35700910; rs35500489; rs35104320; rs35727441; rs34796953; rs7369268; rs7368786; rs28591627; rs28420122; rs35584537; rs11691743; rs35123035; rs34032155; rs28910008; rs4927605; rs2885360; rs3036100; rs28910587; rs34933514; rs28911486; rs2090153; rs34445751; rs11404899; rs35682038; rs4927629; rs35388919; rs34044289; rs11898092; rs12475212; rs28683616; rs28409666; rs11893496; rs3036105; rs2175979; rs28909413; rs35858346; rs28913268; rs34602774; rs34131144; rs3036079; rs4927620; rs28682482; rs13409826; rs35614838; rs34480829; rs12992385; rs28911479; rs28913025; rs35623494; rs28909995; rs36175402; rs13418129; rs13406835; rs34046827; rs28915681; rs11687965; rs35008230; rs13006236; rs5828824; rs34879368; rs28911169; rs9973952; rs13417585; rs28912976; rs13010957; rs9973955; rs13020631; rs35943116; rs28909398; rs13423107; rs28461932; rs13012709; rs28910593; rs13423282; rs4927596; rs13014527; rs10191653; rs34064729; rs11673992; rs9750163; rs9677530; rs28909404; rs4927626; rs13404230; rs7583423; rs28910569; rs35290486; rs2361747; rs13006630; rs10181396; rs9973911; rs28991282; rs28915682; rs28911489; rs28437028; rs5828823; rs28681289; rs13404488; rs28912997; rs10170298; rs28913015; rs13014542; rs13385523; rs13027419; rs11689386; rs35839340; rs13036125; rs28910009; rs34541512; rs34790485; rs28677046; rs28910596; rs34413535; rs34531889; rs28909370; rs11687810; rs9679416; rs34950864; rs2203399; rs34932469; rs10523977; rs11673953; rs34234148; rs12986550; rs28620935; rs2090152; rs13026363; rs28909409; rs28913026; rs28489465; rs35201002; rs13403910; rs34521796; rs28913027; rs11887001; rs35836927; rs28432167; rs10197112; rs28910592; rs28910570; rs7579188; rs34088587; rs11371261; rs13402950; rs12476325; rs12151527; rs28913002; rs4927595; rs10634971; rs35224341; rs35631326; rs13403265; rs2885359; rs28911477; rs13000185; rs28991286; rs28910004; rs11673934; rs28909405; rs13031191; rs28913032; rs28991291; rs28909985; rs28991569; rs35374888; rs10179394; rs28909984; rs13407296; rs10192959; rs10202105; rs10206900; rs10890517; rs11211645; rs11675342; rs11675434; rs11678852; rs11681698; rs11682968; rs11685159; rs11686524; rs11686775; rs11694732; rs12469603; rs12471910; rs12990372; rs13017252; rs13390616; rs13400534; rs13407974; rs13413096; rs13413987; rs13414537; rs13426896; rs1567920; rs17091606; rs17091611; rs17091616; rs17786733; rs1828864; rs2298873; rs2298874; rs35743195; rs6605278; rs6705087; rs9677074

# Metabolic_Enzyme_1_General_References:
3475693; 3453124; 2548579; 2308857; 12454013; 3654979; 2383265; 7550241; 9024270; 10468986; 10084596; 9924196; 11061528; 11415848; 11916616; 12213873; 11874711; 12938097

# Metabolic_Enzyme_1_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7546

# Macromolecular_Interacting_Partner_1_Name:
Prolactin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
PRL

# Macromolecular_Interacting_Partner_1_Gene_Name:
PRL

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Prolactin precursor
MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN
EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG
LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
227

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
25876

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.99

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Prolactin acts primarily on the mammary gland by promoting lactation

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_1_Signals:
1-28

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
34211

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
PRL_HUMAN (P01236)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
PRL

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
PRL

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9445

# Macromolecular_Interacting_Partner_1_PDB_ID:
1RW5

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>684 bp
ATGAACATCAAAGGATCGCCATGGAAAGGGTCCCTCCTGCTGCTGCTGGTGTCAAACCTG
CTGCTGTGCCAGAGCGTGGCCCCCTTGCCCATCTGTCCCGGCGGGGCTGCCCGATGCCAG
GTGACCCTTCGAGACCTGTTTGACCGCGCCGTCGTCCTGTCCCACTACATCCATAACCTC
TCCTCAGAAATGTTCAGCGAATTCGATAAACGGTATACCCATGGCCGGGGGTTCATTACC
AAGGCCATCAACAGCTGCCACACTTCTTCCCTTGCCACCCCCGAAGACAAGGAGCAAGCC
CAACAGATGAATCAAAAAGACTTTCTGAGCCTGATAGTCAGCATATTGCGATCCTGGAAT
GAGCCTCTGTATCATCTGGTCACGGAAGTACGTGGTATGCAAGAAGCCCCGGAGGCTATC
CTATCCAAAGCTGTAGAGATTGAGGAGCAAACCAAACGGCTTCTAGAGGGCATGGAGCTG
ATAGTCAGCCAGGTTCATCCTGAAACCAAAGAAAATGAGATCTACCCTGTCTGGTCGGGA
CTTCCATCCCTGCAGATGGCTGATGAAGAGTCTCGCCTTTCTGCTTATTATAACCTGCTC
CACTGCCTACGCAGGGATTCACATAAAATCGACAATTATCTCAAGCTCCTGAAGTGCCGA
ATCATCCACAACAACAACTGCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00566

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_1_Locus:
6p22.2-p21.3

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
6260780; 6325171; 2050267; 6146607; 9266104; 925136; 1126929

# Macromolecular_Interacting_Partner_1_References:
6127069

# Macromolecular_Interacting_Partner_2_ID:
7549

# Macromolecular_Interacting_Partner_2_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
INS

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_2_Signals:
1-24

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
INS

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_2_Locus:
11p15.5

# Macromolecular_Interacting_Partner_2_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_2_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_2_References:
11048659; 11945437; 6758860; 7009145

# Macromolecular_Interacting_Partner_3_ID:
7975

# Macromolecular_Interacting_Partner_3_Name:
Tyrosine 3-monooxygenase

# Macromolecular_Interacting_Partner_3_Synonyms:
Tyrosine 3-hydroxylase; TH

# Macromolecular_Interacting_Partner_3_Gene_Name:
TH

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Tyrosine 3monooxygenase
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTP
RSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPR
ATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVR
QVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEI
AFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNI
PQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCC
HELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQNGEVKAYG
AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYAS
RIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
528

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
58525

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  tyrosine 3-monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  catecholamine metabolism
Process:  catecholamine biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_3_Specific_Function:
Plays an important role in the physiology of adrenergic neurons

# Macromolecular_Interacting_Partner_3_Pathway:
map00350  Tyrosine metabolism

# Macromolecular_Interacting_Partner_3_Reaction:
L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00351:Biopterin_H

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
EC 1.14.16.2

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
37127

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
TY3H_HUMAN (P07101)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
TH

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
TH

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:11782

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1575 bp
ATGCCCACCCCCGACGCCACCACGCCACAGGCCAAGGGCTTCCGCAGGGCCGTGTCTGAG
CTGGACGCCAAGCAGGCAGAGGCCATCATGGGCGCCCCGGGGCCCAGCCTCACAGGCTCT
CCGTGGCCTGGAACTGCAGCCCCAGCTGCATCCTACACCCCCACCCCAAGGTCCCCGCGG
TTCATTGGGCGCAGGCAGAGCCTCATCGAGGACGCCCGCAAGGAGCGGGAGGCGGCGGTG
GCAGCAGCGGCCGCTGCAGTCCCCTCGGAGCCCGGGGACCCCCTGGAGGCTGTGGCCTTT
GAGGAGAAGGAGGGGAAGGCCGTGCTAAACCTGCTCTTCTCCCCGAGGGCCACCAAGCCC
TCGGCGCTGTCCCGAGCTGTGAAGGTGTTTGAGACGTTTGAAGCCAAAATCCACCATCTA
GAGACCCGGCCCGCCCAGAGGCCGCGAGCTGGGGGCCCCCACCTGGAGTACTTCGTGCGC
CTCGAGGTGCGCCGAGGGGACCTGGCCGCCCTGCTCAGTGGTGTGCGCCAGGTGTCAGAG
GACGTGCGCAGCCCCGCGGGGCCCAAGGTCCCCTGGTTCCCAAGAAAAGTGTCAGAGCTG
GACAAGTGTCATCACCTGGTCACCAAGTTCGACCCTGACCTGGACTTGGACCACCCGGGC
TTCTCGGACCAGGTGTACCGCCAGCGCAGGAAGCTGATTGCTGAGATCGCCTTCCAGTAC
AGGCACGGCGACCCGATTCCCCGTGTGGAGTACACCGCCGAGGAGATTGCCACCTGGAAG
GAGGTCTACACCACGCTGAAGGGCCTCTACGCCACGCACGCCTGCGGGGAGCACCTGGAG
GCCTTTGCTTTGCTGGAGCGCTTCAGCGGCTACCGGGAAGACAATATCCCCCAGCTGGAG
GACGTCTCCCGCTTCCTGAAGGAGCGCACGGGCTTCCAGCTGCGGCCTGTGGCCGGCCTG
CTGTCCGCCCGGGACTTCCTGGCCAGCCTGGCCTTCCGCGTGTTCCAGTGCACCCAGTAT
ATCCGCCACGCGTCCTCGCCCATGCACTCCCCTGAGCCGGACTGCTGCCACGAGCTGCTG
GGGCACGTGCCCATGCTGGCCGACCGCACCTTCGCGCAGTTCTCGCAGGACATTGGCCTG
GCGTCCCTGGGGGCCTCGGATGAGGAAATTGAGAAGCTGTCCACGCTGTCATGGTTCACG
GTGGAGTTCGGGCTGTGTAAGCAGAACGGGGAGGTGAAGGCCTATGGTGCCGGGCTGCTG
TCCTCCTACGGGGAGCTCCTGCACTGCCTGTCTGAGGAGCCTGAGATTCGGGCCTTCGAC
CCTGAGGCTGCGGCCGTGCAGCCCTACCAAGACCAGACGTACCAGTCAGTCTACTTCGTG
TCTGAGAGCTTCAGTGACGCCAAGGACAAGCTCAGGAGCTATGCCTCACGCATCCAGCGC
CCCTTCTCCGTGAAGTTCGACCCGTACACGCTGGCCATCGACGTGCTGGACAGCCCCCAG
GCCGTGCGGCGCTCCCTGGAGGGTGTCCAGGATGAGCTGGACACCCTTGCCCATGCGCTG
AGTGCCATTGGCTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
Y00414

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11p15.5

# Macromolecular_Interacting_Partner_3_SNPs:
rs6356; rs7950050; rs6357; rs34510659; rs11826260; rs3842725; rs10840489; rs11825601; rs4074905; rs12419447; rs2070762; rs7482510; rs3842722; rs7925924; rs7942881; rs11826130; rs7483805; rs7483056; rs4072826; rs4072824; rs7925375; rs7479936; rs4072823; rs3842723; rs10743149; rs10770140; rs3842727; rs7119275; rs7115640; rs10840490; rs10770141; rs11564711; rs10840491; rs3842726; rs11042962; rs10770142; rs28934581; rs28934579; rs28934580; rs1800033; rs36097848; rs3842724; rs1799833; rs11564716; rs34723540; rs6578990; rs11042950; rs3842721; rs35596265; rs11564713; rs11564712; rs36009557; rs4930043; rs36010304; rs7925784; rs35996457; rs4072825; rs35125951; rs11564714; rs35444567; rs34965351; rs11564715; rs11564717; rs10734659; rs11564718; rs1800032; rs10743152; rs10770143; rs10840447; rs10840452; rs10840495; rs10840496; rs10840502; rs11042965; rs11042966; rs11042971; rs11042976; rs11042978; rs11042982; rs11042984; rs11042987; rs11564709; rs11564710; rs11564720; rs2000993; rs28494588; rs28933985; rs3842733; rs3842738; rs3842741; rs3842748; rs3842752; rs3842753; rs3842754; rs3842756; rs3842768; rs3842769; rs3842770; rs3842775; rs4929964; rs4929966; rs4930046; rs5505; rs5506; rs5507; rs6578993; rs689; rs7110099; rs7128097; rs7482891; rs7936868

# Macromolecular_Interacting_Partner_3_General_References:
2882428; 2888085; 2887169; 2902075; 2892893; 2896667; 7814018; 7789962; 8528210; 8817341; 9613851; 9754624; 9703425; 10391209; 11246459

# Macromolecular_Interacting_Partner_3_References:
11696250; 2110978; 2896667

# Macromolecular_Interacting_Partner_4_ID:
8304

# Macromolecular_Interacting_Partner_4_Name:
Thyroglobulin precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
TG

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Thyroglobulin precursor
MALVLEIFTLLASICWVSANIFEYQVDAQPLRPCELQRETAFLKQADYVPQCAEDGSFQT
VQCQNDGRSCWCVGANGSEVLGSRQPGRPVACLSFCQLQKQQILLSGYINSTDTSYLPQC
QDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRCPRSCEIRNRRLLHGVGDKSP
PQCSAEGEFMPVQCKFVNTTDMMIFDLVHSYNRFPDAFVTFSSFQRRFPEVSGYCHCADS
QGRELAETGLELLLDEIYDTIFAGLDLPSTFTETTLYRILQRRFLAVQSVISGRFRCPTK
CEVERFTATSFGHPYVPSCRRNGDYQAVQCQTEGPCWCVDAQGKEMHGTRQQGEPPSCAE
GQSCASERQQALSRLYFGTSGYFSQHDLFSSPEKRWASPRVARFATSCPPTIKELFVDSG
LLRPMVEGQSQQFSVSENLLKEAIRAIFPSRGLARLALQFTTNPKRLQQNLFGGKFLVNV
GQFNLSGALGTRGTFNFSQFFQQLGLASFLNGGRQEDLAKPLSVGLDSNSSTGTPEAAKK
DGTMNKPTVGSFGFEINLQENQNALKFLASLLELPEFLLFLQHAISVPEDVARDLGDVME
TVLSSQTCEQTPERLFVPSCTTEGSYEDVQCFSGECWCVNSWGKELPGSRVRGGQPRCPT
DCEKQRARMQSLMGSQPAGSTLFVPACTSEGHFLPVQCFNSECYCVDAEGQAIPGTRSAI
GKPKKCPTPCQLQSEQAFLRTVQALLSNSSMLPTLSDTYIPQCSTDGQWRQVQCNGPPEQ
VFELYQRWEAQNKGQDLTPAKLLVKIMSYREAASGNFSLFIQSLYEAGQQDVFPVLSQYP
SLQDVPLAALEGKRPQPRENILLEPYLFWQILNGQLSQYPGSYSDFSTPLAHFDLRNCWC
VDEAGQELEGMRSEPSKLPTCPGSCEEAKLRVLQFIRETEEIVSASNSSRFPLGESFLVA
KGIRLRNEDLGLPPLFPPREAFAEQFLRGSDYAIRLAAQSTLSFYQRRRFSPDDSAGASA
LLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSLQIPQCPTTCEKS
RTSGLLSSWKQARSQENPSPKDLFVPACLETGEYARLQASGAGTWCVDPASGEELRPGSS
SSAQCPSLCNVLKSGVLSRRVSPGYVPACRAEDGGFSPVQCDQAQGSCWCVMDSGEEVPG
TRVTGGQPACESPRCPLPFNASEVVGGTILCETISGPTGSAMQQCQLLCRQGSWSVFPPG
PLICSLESGRWESQLPQPRACQRPQLWQTIQTQGHFQLQLPPGKMCSADYADLLQTFQVF
ILDELTARGFCQIQVKTFGTLVSIPVCNNSSVQVGCLTRERLGVNVTWKSRLEDIPVASL
PDLHDIERALVGKDLLGRFTDLIQSGSFQLHLDSKTFPAETIRFLQGDHFGTSPRTWFGC
SEGFYQVLTSEASQDGLGCVKCPEGSYSQDEECIPCPVGFYQEQAGSLACVPCPVGRTTI
SAGAFSQTHCVTDCQRNEAGLQCDQNGQYRASQKDRGSGKAFCVDGEGRRLPWWETEAPL
EDSQCLMMQKFEKVPESKVIFDANAPVAVRSKVPDSEFPVMQCLTDCTEDEACSFFTVST
TEPEISCDFYAWTSDNVACMTSDQKRDALGNSKATSFGSLRCQVKVRSHGQDSPAVYLKK
GQGSTTTLQKRFEPTGFQNMLSGLYNPIVFSASGANLTDAHLFCLLACDRDLCCDGFVLT
QVQGGAIICGLLSSPSVLLCNVKDWMDPSEAWANATCPGVTYDQESHQVILRLGDQEFIK
SLTPLEGTQDTFTNFQQVYLWKDSDMGSRPESMGCRKDTVPRPASPTEAGLTTELFSPVD
LNQVIVNGNQSLSSQKHWLFKHLFSAQQANLWCLSRCVQEHSFCQLAEITESASLYFTCT
LYPEAQVCDDIMESNAQGCRLILPQMPKALFRKKVILEDKVKNFYTRLPFQKLMGISIRN
KVPMSEKSISNGFFECERRCDADPCCTGFGFLNVSQLKGGEVTCLTLNSLGIQMCSEENG
GAWRILDCGSPDIEVHTYPFGWYQKPIAQNNAPSFCPLVVLPSLTEKVSLDSWQSLALSS
VVVDPSIRHFDVAHVSTAATSNFSAVRDLCLSECSQHEACLITTLQTQPGAVRCMFYADT
QSCTHSLQGQNCRLLLREEATHIYRKPGISLLSYEASVPSVPISTHGRLLGRSQAIQVGT
SWKQVDQFLGVPYAAPPLAERRFQAPEPLNWTGSWDASKPRASCWQPGTRTSTSPGVSED
CLYLNVFIPQNVAPNASVLVFFHNTMDREESEGWPAIDGSFLAAVGNLIVVTASYRVGVF
GFLSSGSGEVSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTAR
ATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPMSSSQEVVSCLRQKPAN
VLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQDDGLINRA
KAVKQFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRAL
ENATRDYFIICPIIDMASAWAKRARGNVFMYHAPENYGHGSLELLADVQFALGLPFYPAY
EGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGENYKEF
SELLPNRQGLKKADCSFWSKYISSLKTSADGAKGGQSAESEEEELTAGSGLREDLLSLQE
PGSKTYSK

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
2768

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
304792

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
5.26

# Macromolecular_Interacting_Partner_4_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Lipid transport and metabolism 

# Macromolecular_Interacting_Partner_4_Specific_Function:
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3)

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00135:COesterase;
PF07699:GCC2_GCC3;
PF00086:Thyroglobulin_1

# Macromolecular_Interacting_Partner_4_Signals:
1-19

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
37174

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
THYG_HUMAN (P01266)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
TG

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
TG

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11764

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>8304 bp
ATGGCCCTGGTCCTGGAGATCTTCACCCTGCTGGCCTCCATCTGCTGGGTGTCGGCCAAT
ATCTTCGAGTACCAGGTTGATGCCCAGCCCCTTCGTCCCTGTGAGCTGCAGAGGGAAACG
GCCTTTCTGAAGCAAGCAGACTACGTGCCCCAGTGTGCAGAGGATGGCAGCTTCCAGACT
GTCCAGTGCCAGAACGACGGCCGCTCCTGCTGGTGTGTGGGTGCCAACGGCAGTGAAGTG
CTGGGCAGCAGGCAGCCAGGACGGCCTGTGGCTTGTCTGTCATTTTGTCAGCTACAGAAA
CAGCAGATCTTACTGAGTGGCTACATTAACAGCACAGACACCTCCTACCTCCCTCAGTGT
CAGGATTCAGGGGACTACGCGCCTGTTCAGTGTGATGTGCAGCATGTCCAGTGCTGGTGT
GTGGACGCAGAGGGGATGGAGGTGTATGGGACCCGCCAGCTGGGGAGGCCAAAGCGATGT
CCAAGGAGCTGTGAAATAAGAAATCGTCGTCTTCTCCACGGGGTGGGAGATAAGTCACCA
CCCCAGTGTTCTGCGGAGGGAGAGTTTATGCCTGTCCAGTGCAAATTTGTCAACACCACA
GACATGATGATTTTTGATCTGGTCCACAGCTACAACAGGTTTCCAGATGCATTTGTGACC
TTCAGTTCCTTCCAGAGGAGGTTCCCTGAGGTATCTGGGTATTGCCACTGTGCTGACAGC
CAAGGGCGGGAACTGGCTGAGACAGGTTTGGAGTTGTTACTGGATGAAATTTATGACACC
ATTTTTGCTGGCCTGGACCTTCCTTCCACCTTCACTGAAACCACCCTGTACCGGATACTG
CAGAGACGGTTCCTCGCAGTTCAATCAGTCATCTCTGGCAGATTCCGATGCCCCACAAAA
TGTGAAGTGGAGCGGTTTACAGCAACCAGCTTTGGTCACCCCTATGTTCCAAGCTGCCGC
CGAAATGGCGACTATCAGGCGGTGCAGTGCCAGACGGAAGGGCCCTGCTGGTGTGTGGAC
GCCCAGGGGAAGGAAATGCATGGAACCCGGCAGCAAGGGGAGCCGCCATCTTGTGCTGAA
GGCCAATCTTGTGCCTCCGAAAGGCAGCAGGCCTTGTCCAGACTCTACTTTGGGACCTCA
GGCTACTTCAGCCAGCACGACCTGTTCTCTTCCCCAGAGAAAAGATGGGCCTCTCCAAGA
GTAGCCAGATTTGCCACATCCTGCCCACCCACGATCAAGGAGCTCTTTGTGGACTCTGGG
CTTCTCCGCCCAATGGTGGAGGGACAGAGCCAACAGTTTTCTGTCTCAGAAAATCTTCTC
AAAGAAGCCATCCGAGCAATTTTTCCCTCCCGAGGGCTGGCTCGTCTTGCCCTTCAGTTT
ACCACCAACCCAAAGAGACTCCAGCAAAACCTTTTTGGAGGGAAATTTTTGGTGAATGTT
GGCCAGTTTAACTTGTCTGGAGCCCTTGGCACAAGAGGCACATTTAACTTCAGTCAATTT
TTCCAGCAACTTGGTCTTGCAAGCTTCTTGAATGGAGGGAGACAAGAAGATTTGGCCAAG
CCACTCTCTGTGGGATTAGATTCAAATTCTTCCACAGGAACCCCTGAAGCTGCTAAGAAG
GATGGTACTATGAATAAGCCAACTGTGGGCAGCTTTGGCTTTGAAATTAACCTACAAGAG
AACCAAAATGCCCTCAAATTCCTTGCTTCTCTCCTGGAGCTTCCAGAATTCCTTCTCTTC
TTGCAACATGCTATCTCTGTGCCAGAAGATGTGGCAAGAGATTTAGGTGATGTGATGGAA
ACGGTACTCGACTCCCAGACCTGTGAGCAGACACCTGAAAGGCTATTTGTCCCATCATGC
ACGACAGAAGGAAGCTATGAGGATGTCCAATGCTTTTCCGGAGAGTGCTGGTGTGTGAAT
TCCTGGGGCAAAGAGCTTCCAGGCTCAAGAGTCAGAGATGGACAGCCAAGGTGCCCCACA
GACTGTGAAAAGCAAAGGGCTCGCATGCAAAGCCTCATGGGCAGCCAGCCTGCTGGCTCC
ACCTTGTTTGTCCCTGCTTGTACTAGTGAGGGACATTTCCTGCCTGTCCAGTGCTTCAAC
TCAGAGTGCTACTGTGTTGATGCTGAGGGTCAGGCCATTCCTGGAACTCGAAGTGCAATA
GGGAAGCCCAAGAAATGCCCCACGCCCTGTCAATTACAGTCTGAGCAAGCTTTCCTCAGG
ACGGTGCAGGCCCTGCTCTCTAACTCCAGCATGCTACCCACCCTTTCCGACACCTACATC
CCACAGTGCAGCACCGATGGGCAGTGGAGACAAGTGCAATGCAATGGGCCTCCTGAGCAG
GTCTTCGAGTTGTACCAACGATGGGAGGCTCAGAACAAGGGCCAGGATCTGACGCCTGCC
AAGCTGCTAGTGAAGATCATGAGCTACAGAGAAGCAGCTTCCGGAAACTTCAGTCTCTTT
ATTCAAAGTCTGTATGAGGCTGGCCAGCAAGATGTCTTCCCGGTGCTGTCACAATACCCT
TCTCTGCAAGATGTCCCACTAGCAGCACTGGAAGGGAAACGGCCCCAGCCCAGGGAGAAT
ATCCTCCTGGAGCCCTACCTCTTCTGGCAGATCTTAAATGGCCAACTCAGCCAATACCCG
GGGTCCTACTCAGACTTCAGCACTCCTTTGGCACATTTTGATCTTCGGAACTGCTGGTGT
GTGGATGAGGCTGGCCAAGAACTGGAAGGAATGCGGTCTGAGCCAAGCAAGCTCCCAACG
TGTCCTGGCTCCTGTGAGGAAGCAAAGCTCCGTGTACTGCAGTTCATTAGGGAAACGGAA
GAGATTGTTTCAGCTTCCAACAGTTCTCGGTTCCCTCTGGGGGAGAGTTTCCTGGTGGCC
AAGGGAATCCGGCTGAGGAATGAGGACCTCGGCCTTCCTCCGCTCTTCCCGCCCCGGGAG
GCTTTCGCGGAGTTTCTGCGTGGGAGTGATTACGCCATTCGCCTGGCGGCTCAGTCTACC
TTAAGCTTCTATCAGAGACGCCGCTTTTCCCCGGACGACTCGGCTGGAGCATCCGCCCTT
CTGCGGTCGGGCCCCTACATGCCACAGTGTGATGCGTTTGGAAGTTGGGAGCCTGTGCAG
TGCCACGCTGGGACTGGGCACTGCTGGTGTGTAGATGAGAAAGGAGGGTTCATCCCTGGC
TCACTGACTGCCCGCTCTCTGCAGATTCCACAGTGCCCGACAACCTGCGAGAAATCTCGA
ACCAGTGGGCTGCTTTCCAGTTGGAAACAGGCTAGATCCCAAGAAAACCCATCTCCAAAA
GACCTGTTCGTCCCAGCCTGCCTAGAAACAGGAGAATATGCCAGGCTGCAGGCATCGGGG
GCTGGCACCTGGTGTGTGGACCCTGCATCAGGAGAAGAGTTGCGGCCTGGCTCGAGCAGC
AGTGCCCAGTGCCCAAGCCTCTGCAATGTGCTCAAGAGTGGAGTCCTCTCTAGGAGAGTC
AGCCCAGGCTATGTCCCAGCCTGCAGGGCAGAGGATGGGGGCTTTTCCCCAGTGCAATGT
GACCAGGCCCAGGGCAGCTGCTGGTGTGTCATGGACAGCGGAGAAGAGGTGCCTGGGACG
CGCGTGACCGGGGGCCAGCCCGCCTGTGAGAGCCCGCGGTGTCCGCTGCCATTCAACGCG
TCGGAGGTGGTTGGTGGAACAATCCTGTGTGAGACAATCTCGGGCCCCACAGGCTCTGCC
ATGCAGCAGTGCCAATTGCTGTGCCGCCAAGGCTCCTGGAGCGTGTTTCCACCAGGGCCA
TTGATATGTAGCCTGGAGAGCGGACGCTGGGAGTCACAGCTGCCTCAGCCCCGGGCCTGC
CAACGGCCCCAGCTGTGGCAGACCATCCAGACCCAAGGGCACTTTCAGCTCCAGCTCCCG
CCGGGCAAGATGTGCAGTGCTGACTACGCGGGTTTGCTGCAGACTTTCCAGGTTTTCATA
TTGGATGAGCTGACAGCCCGCGGCTTCTGCCAGATCCAGGTGAAGACTTTTGGCACCCTG
GTTTCCATTCCTGTCTGCAACAACTCCTCTGTGCAGGTGGGTTGTCTGACCAGGGAGCGT
TTAGGAGTGAATGTTACATGGAAATCACGGCTTGAGGACATCCCAGTGGCTTCTCTTCCT
GACTTACATGACATTGAGAGAGCCTTGGTGGGCAAGGATCTCCTTGGGCGCTTCACAGAT
CTGATCCAGAGTGGCTCATTCCAGCTTCATCTGGACTCCAAGACGTTCCCAGCGGAAACC
ATCCGCTTCCTCCAAGGGGACCACTTTGGCACCTCTCCTAGGACACGGTTTGGGTGCTCG
GAAGGATTCTACCAAGTCTTGACAAGTGAGGCCAGTCAGGACGGACTGGGATGCGTTAAG
TGCCATGAAGGAAGCTATTCCCAAGATGAGGAATGCATTCCTTGTCCTGTTGGATTCTAC
CAAGAACAGGCAGGGAGCTTGGCCTGTGTCCCATGTCCTGTGGGCAGAACGACCATTTCT
GCCGGAGCTTTCAGCCAGACTCACTGTGTCACTGACTGTCAGAGGAACGAAGCAGGCCTG
CAATGTGACCAGAATGGCCAGTATCGAGCCAGCCAGAAGGACAGGGGCAGTGGGAAGGCC
TTCTGTGTGGACGGCGAGGGGCGGAGGCTGCCATGGTGGGAAACAGAGGCCCCTCTTGAG
GACTCACAGTGTTTGATGATGCAGAAGTTTGAGAAGGTTCCAGAATCAAAGGTGATCTTC
GACGCCAATGCTCCTGTGGCTGTCAGATCCAAAGTTCCTGATTCTGAGTTCCCCGTGATG
CAGTGCTTGACAGATTGCACAGAGGACGAGGCCTGCAGCTTCTTCACCGTGTCCACGACG
GAGCCAGAGATTTCCTGTGATTTCTATGCTTGGACAAGTGACAATGTTGCCTGCATGACT
TCTGACCAGAAACGAGATGCACTGGGGAACTCAAAGGCCACCAGCTTTGGAAGTCTTCGC
TGCCAGGTGAAAGTGAGGAGCCATGGTCAAGATTCTCCAGCTGTGTATTTGAAAAAGGGC
CAAGGATCCACCACAACACTTCAGAAACGCTTTGAACCCACTGGTTTCCAAAACATGCTT
TCTGGATTGTACAACCCCATTGTGTTCTCAGCCTCAGGAGCCAATCTAACCGATGCTCAC
CTCTTCTGTCTTCTTGCATGCGACCGTGATCTGTGTTGCGATGGCTTCGTCCTCACACAG
GTTCAAGGAGGTGCCATCATCTGTGGGTTGCTGAGCTCACCCAGTGTCCTGCTTTGTAAT
GTCAAAGACTGGATGGATCCCTCTGAAGCCTGGGCTAATGCTACATGTCCTGGTGTGACA
TATGACCAGGAGAGCCACCAGGTGATATTGCGTCTTGGAGACCAGGAGTTCATCAAGAGT
CTGACACCCTTAGAAGGAACTCAAGACACCTTTACCAATTTTCAGCAGGTTTATCTCTGG
AAAGATTCTGACATGGGGTCTCGGCCTGAGTCTATGGGATGTAGAAAAAACACAGTGCCA
AGGCCAGCATCTCCAACAGAAGCAGGTTTGACAACAGAACTTTTCTCCCCTGTGGACCTC
AACCAGGTCATTGTCAATGGAAATCAATCACTATCCAGCCAGAAGCACTGGCTTTTCAAG
CACCTGTTTTCAGCCCAGCAGGCAAACCTATGGTGCCTTTCTCGTTGTGTGCAGGAGCAC
TCTTTCTGTCAGCTCGCAGAGATAACAGAGAGTGCATCCTTGTACTTCACCTGCACCCTC
TACCCAGAGGCACAGGTGTGTGATGACATCATGGAGTCCAATACCCAGGGCTGCAGACTG
ATCCTGCCTCAGATGCCAAAGGCCCTGTTCCGGAAGAAAGTTATACTGGAAGATAAAGTG
AAGAACTTTTACACTCGCCTGCCGTTCCAAAAACTGATGGGGATATCCATTAGAAATAAA
GTGCCCATGTCTGAAAAATCTATTTCTAATGGGTTCTTTGAATGTGAACGACGGTGCGAT
GCGGACCCATGCTGCACTGGCTTTGGATTTCTAAATGTTTCCCAGTTAAAAGGAGGAGAG
GTGACATGTCTCACTCTGAACAGCTTGGGAATTCAGATGTGCAGTGAGGAGAATGGAGGA
GCCTGGCGCATTTTGGACTGTGGCTCTCCTGACATTGAAGTCCACACCTATCCCTTCGGA
TGGTACCAGAAGCCCATTGCTCAAAATAATGCTCCCAGTTTTTGCCCTTTGGTTGTTCTG
CCTTCCCTCACAGAGAAAGTGTCTCTGGAATCGTGGCAGTCCCTGGCCCTCTCTTCAGTG
GTTGTTGATCCATCCATTAGGCACTTTGATGTTGCCCATGTCAGCACTGCTGCCACCAGC
AATTTCTCTGCTGTCCGAGACCTCTGTTTGTCGGAATGTTCCCAACATGAGGCCTGTCTC
ATCACCACTCTGCAAACCCAACTCGGGGCTGTGAGATGTATGTTCTATGCTGATACTCAA
AGCTGCACACATAGTCTGCAGGGTCGGAACTGCCGACTTCTGCTTCGTGAAGAGGCCACC
CACATCTACCGGAAGCCAGGAATCTCTCTGCTCAGCTATGAGGCATCTGTACCTTCTGTG
CCCATTTCCACCCATGGCCGGCTGCTGGGCAGGTCCCAGGCCATCCAGGTGGGTACCTCA
TGGAAGCAAGTGGACCAGTTCCTTGGAGTTCCATATGCTGCCCCGCCCCTGGCAGAGAGG
CACTTCCAGGCACCAGAGCCCTTGAACTGGACAGGCTCCTGGGATGCCAGCAAGCCAAGG
GCCAGCTGCTGGCAGCCAGGCACCAGAACATCCACGTCTCCTGGAGTCAGTGAAGATTGT
TTGTATCTCAATGTGTTCATCCCTCAGAATGTGGCCCCTAACGCGTCTGTGCTGGTGTTC
TTCCACAACACCATGGACAGGGAGGAGAGTGAAGGATGGCCGGCTATCGACGGCTCCTTC
TTGGCTGCTGTTGGCAACCTCATCGTGGTCACTGCCAGCTACCGAGTGGGTGTCTTCGGC
TTCCTGAGTTCTGGATCCGGAGAGGTGAGTGGCAACTGGGGGCTGCTGGACCAGGTGGCG
GCTCTGACCTGGGTGCAGACCCACATCCGAGGATTTGGCGGGGACCCTCGGCGCGTGTCC
CTGGCAGCAGACCGTGGCGGGGCTGATGTGGCCAGCATCCACCTTCTCACGGCCAGGGCC
ACCAACTCCCAACTTTTCCGGAGAGCTGTGCTGATGGGAGGCTCCGCACTCTCCCCGGCC
GCCGTCATCAGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAGGAGGTCAGT
TGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCCGCCAGAAGCCTGCCAATGTC
CTCAATGATGCCCAGACCAAGCTCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCT
GTGATCGATGGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGGTCTTTATGG
GTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACGGGCTCATCAACAGAGCAAAG
GCTGTGAAGCAATTTGAGGAAAGTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAG
GCACTGCAGAATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCTGCTGCTACA
TGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCTCCTTCTCCCGGGCTCTGGAG
AATGCCACCCGGGACTACTTTATCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCA
AAGAGGGCCCGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGCCATGGCAGC
CTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTCCCTTCTACCCAGCCTACGAG
GGGCAGTTTTCTCTGGAGGAGAAGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCAC
TTCATCAGATCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTACCCACATTT
GCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAGAGAACTACAAGGAGTTCAGT
GAGCTGCTCCCCAATCGACAGGGCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTAC
ATCTCGTCTCTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCAGAGAGTGAA
GAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATCTCCTAAGCCTCCAGGAACCA
GGCTCTAAGACCTACAGCAAGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
X05615

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:8

# Macromolecular_Interacting_Partner_4_Locus:
8q24

# Macromolecular_Interacting_Partner_4_SNPs:
rs853326; rs2069561; rs1133076; rs10091530; rs180222; rs11535853; rs16893332; rs180223; rs12549018; rs2272707; rs3739274; rs2069548; rs11992497; rs2229843; rs16904774; rs2069550; rs2294024; rs853304; rs2228590; rs16904799; rs2294003; rs17693031; rs2069568; rs16904786; rs2250927; rs2741217; rs940075; rs2741228; rs2739075; rs853303; rs2979022; rs2703006; rs866468; rs2702988; rs180211; rs2140296; rs2739143; rs2403882; rs2687810; rs2739156; rs2739060; rs2703010; rs2204208; rs2246625; rs1523072; rs2248346; rs2739169; rs2741216; rs1357452; rs1474539; rs1000264; rs2244718; rs2739152; rs2687807; rs870685; rs1403481; rs879810; rs2739142; rs2739061; rs2248574; rs2979029; rs2703005; rs873177; rs2702987; rs2142378; rs2739079; rs2246608; rs2979025; rs2687815; rs2739054; rs2979051; rs2687808; rs712054; rs2741209; rs2249869; rs2741223; rs2741205; rs2741210; rs871162; rs2739141; rs2979048; rs2739180; rs885113; rs2741222; rs870539; rs1403480; rs2958670; rs2140295; rs2979020; rs2739071; rs2687834; rs864898; rs2741208; rs2403910; rs2739069; rs2741218; rs2739073; rs2739078; rs2741225; rs853321; rs2687827; rs2702974; rs909359; rs2741211; rs180210; rs2205452; rs2703011; rs876902; rs2958668; rs2741221; rs2142383; rs180208; rs2739148; rs853298; rs872286; rs2739154; rs2245152; rs2979030; rs2703008; rs1523067; rs6988528; rs2005162; rs2958693; rs940074; rs909361; rs2739165; rs2739151; rs2979032; rs4736622; rs6984038; rs6984052; rs6994110; rs2896692; rs6985454; rs11785557; rs1403487; rs4736625; rs4736613; rs2739166; rs13264468; rs2702999; rs1916274; rs4443645; rs2739155; rs2958688; rs885196; rs3847174; rs4336595; rs6990835; rs4736628; rs2037540; rs7818360; rs6471107; rs712055; rs180202; rs4551333; rs10105992; rs4403389; rs4585737; rs2739057; rs7018140; rs4736432; rs3758113; rs868508; rs10106820; rs2739074; rs4478553; rs2702991; rs2103069; rs885195; rs853318; rs2979035; rs2687813; rs853300; rs2958694; rs10113099; rs872643; rs2703013; rs860471; rs4736626; rs7009823; rs2294025; rs7846474; rs2741213; rs180212; rs872285; rs4540390; rs6982788; rs2739161; rs2958677; rs12545138; rs1403485; rs871402; rs1474540; rs10091983; rs1916275; rs6998833; rs7844761; rs10105189; rs4736433; rs869769; rs2958681; rs2739159; rs1033363; rs853296; rs2958674; rs4236897; rs7844649; rs2687843; rs7827903; rs12541260; rs2739058; rs7832522; rs2272706; rs7015412; rs2177296; rs4236895; rs7829428; rs6990302; rs2091036; rs11785901; rs2256476; rs2979034; rs7827937; rs2739149; rs1523070; rs2261147; rs2958686; rs7827533; rs4736624; rs7825913; rs1533909; rs9297863; rs2958671; rs180213; rs11782322; rs2703004; rs11782262; rs1806535; rs2140297; rs4736623; rs10088449; rs2739177; rs2177297; rs2687822; rs6471109; rs2687819; rs2068128; rs6998423; rs853306; rs4736430; rs6981042; rs2703009; rs1403484; rs180217; rs885194; rs180204; rs2739162; rs7814048; rs2703007; rs2739171; rs2403883; rs2248578; rs2958684; rs4612318; rs4736616; rs11776724; rs7845084; rs1879991; rs2958679; rs7823628; rs4301434; rs7000428; rs9297865; rs4278132; rs7844859; rs940073; rs6999702; rs3161; rs1851571; rs2958687; rs951452; rs7844210; rs2687818; rs7817693; rs7824618; rs11782282; rs4736429; rs2958680; rs4601289; rs865488; rs4736431; rs2739163; rs10095925; rs11784620; rs6471111; rs940078; rs1403488; rs2958683; rs7828146; rs2739070; rs2979027; rs2687831; rs9969622; rs10088696; rs1033361; rs1000263; rs853322; rs2739065; rs6994911; rs4074676; rs2244715; rs2293210; rs11785501; rs11786982; rs872644; rs6992986; rs11990839; rs2741212; rs853308; rs2702973; rs17630941; rs1403491; rs1879992; rs2142379; rs1403483; rs926174; rs2702994; rs16904790; rs6981934; rs6993250; rs2958692; rs4548165; rs16904836; rs17702843; rs12679617; rs180219; rs180207; rs862503; rs2687809; rs16904775; rs853297; rs4377944; rs11777992; rs12545159; rs2739064; rs4363178; rs2739053; rs2142384; rs2687832; rs2739170; rs10100520; rs16904796; rs6471112; rs2687828; rs2222452; rs11782027; rs2687824; rs4736629; rs180206; rs3779948; rs3847173; rs16904832; rs10108988; rs869767; rs865909; rs2248331; rs2687830; rs16904802; rs10103821; rs853323; rs11991061; rs3992996; rs2739157; rs6471108; rs16904768; rs10435562; rs17703832; rs1403482; rs11780642; rs12677246; rs10106670; rs13251221; rs853309; rs4388441; rs4236898; rs2142380; rs3779966; rs10097042; rs853319; rs7011493; rs7008436; rs10505603; rs7818576; rs2979021; rs7815657; rs6997874; rs2245562; rs853305; rs2703002; rs16904784; rs13279688; rs2687829; rs1403486; rs10956686; rs864897; rs13254463; rs10102602; rs2979018; rs11998272; rs2739068; rs2245048; rs16904782; rs879811; rs7827593; rs10088671; rs16904789; rs3892189; rs2687826; rs2958669; rs2258483; rs3739281; rs13263649; rs2739158; rs10105991; rs13256652; rs2461801; rs4297024; rs180221; rs16904762; rs2687825; rs4736434; rs2467991; rs853301; rs1851572; rs2702992; rs4361742; rs11777934; rs3779955; rs2741229; rs2702995; rs180205; rs10505604; rs2741214; rs10106542; rs2739145; rs4273838; rs2142382; rs860474; rs2979049; rs16904794; rs2687812; rs2739139; rs10086069; rs7002393; rs3779951; rs2702989; rs12675044; rs6988193; rs4236899; rs7845804; rs7832064; rs17701982; rs17705719; rs909362; rs1033362; rs16904805; rs11996654; rs2178970; rs2245047; rs2739063; rs2687841; rs2687814; rs4529449; rs11997527; rs2741204; rs9283959; rs7843609; rs2702985; rs7014451; rs2739164; rs2256782; rs853311; rs13265497; rs853302; rs10108422; rs2702979; rs2687846; rs11995141; rs4736435; rs10110664; rs853310; rs2246624; rs12545027; rs1523071; rs7842044; rs2739176; rs10108641; rs11989874; rs4236900; rs2178969; rs11777970; rs2741207; rs2294023; rs2741215; rs16904798; rs7812835; rs11779360; rs853307; rs2702997; rs864091; rs2687845; rs16904806; rs2244716; rs2739072; rs4736627; rs12681531; rs2687833; rs2739168; rs7002366; rs2979033; rs2246611; rs16904778; rs3779949; rs853316; rs2896681; rs1573825; rs4736631; rs2178968; rs2248330; rs12544732; rs2245055; rs2979037; rs581399; rs16904824; rs2979026; rs4736630; rs10092459; rs2687820; rs860473; rs6999594; rs16904801; rs9297864; rs180215; rs3857936; rs2702990; rs2687840; rs17693374; rs13263087; rs11990445; rs10096431; rs10956687; rs16904770; rs2687817; rs16904841; rs4142713; rs16904797; rs10105779; rs6984543; rs16904764; rs7844184; rs9649970; rs10093801; rs4606039; rs16904788; rs34349286; rs2979038; rs11774274; rs16904822; rs11778171; rs2739175; rs2958676; rs2294002; rs9774204; rs2979045; rs12549851; rs16904842; rs2739076; rs7013000; rs2979019; rs12677481; rs16904779; rs13253544; rs16904829; rs7001708; rs7013643; rs4641045; rs10095020; rs17623738; rs16904783; rs909357; rs2958700; rs4430073; rs2739140; rs17613233; rs9969645; rs7836183; rs2256252; rs180216; rs17694217; rs11988147; rs10108459; rs1033360; rs2979036; rs16904825; rs16904781; rs2979040; rs2293999; rs17684629; rs2741227; rs7830370; rs12543039; rs4736633; rs16904771; rs17630799; rs967399; rs2142381; rs16904840; rs733735; rs870540; rs180220; rs11784224; rs2246988; rs9297860; rs11784362; rs16904763; rs16904837; rs17703282; rs16904785; rs7824402; rs860475; rs952346; rs3758114; rs16904776; rs2741206; rs9643296; rs2741226; rs10106416; rs2687842; rs2739062; rs11992894; rs12542426; rs2741219; rs16904767; rs16893339; rs6993411; rs10091720; rs2739077; rs16904769; rs10107048; rs16904803; rs2979028; rs2702978; rs10100508; rs2979039; rs11786334; rs7004655; rs11782801; rs16904833; rs1949729; rs16904773; rs2739066; rs6982276; rs16904772; rs17702000; rs6997296; rs13256826; rs6988394; rs10106773; rs16904792; rs872642; rs16904838; rs16904766; rs2739059; rs1403489; rs10103453; rs16904777; rs4142712; rs10099774; rs1554541; rs2958672; rs17693908; rs10956688; rs6994572; rs17705891; rs17624784; rs2702993; rs1523068; rs2702983; rs17693464; rs2958678; rs17633144; rs2979023; rs872645; rs4736621; rs16904780; rs16904761; rs9774265; rs10096095; rs16904828; rs2739144; rs6988035; rs7845018; rs2687823; rs2008303; rs7014463; rs2294000; rs13256171; rs4736614; rs2056525; rs12334347; rs10098314; rs7843654; rs3892606; rs2703003; rs7000137; rs16904793; rs16904839; rs11995077; rs16904765; rs16904800; rs9969601; rs16904827; rs1810396; rs2739067; rs2403911; rs180193; rs180194; rs999101; rs180195; rs12543299; rs2069546; rs2069565; rs2076737; rs2979042; rs2069566; rs12114109; rs2076738; rs2069558; rs35664324; rs35301433; rs2069562; rs16904791; rs2069557; rs11555531; rs13439368; rs2069555; rs2069554; rs3739269; rs10571; rs2958673; rs13264519; rs34791956; rs35549323; rs41383448; rs11356729; rs36076027; rs5895170; rs28376581; rs2103068; rs7830704; rs35937980; rs35412388; rs35317691; rs1851570; rs34552313; rs28506015; rs36055969; rs10604919; rs34562678; rs4607588; rs11779922; rs12544016; rs35270204; rs35137177; rs34773278; rs34136755; rs3779947; rs1523069; rs1474538; rs7843615; rs35394858; rs6993572; rs34099217; rs34868707; rs12680704; rs34642099; rs36014390; rs35803208; rs12676529; rs5895171; rs7834124; rs13276066; rs34047303; rs16904835; rs12674648; rs11340734; rs34810147; rs34771329; rs7011284; rs11777756; rs35105936; rs10099487; rs34588565; rs34748236; rs34455268; rs10095146; rs33925859; rs2739174; rs2741203; rs34313336; rs5895165; rs10618252; rs7000928; rs35589968; rs869768; rs35486009; rs35061080; rs2958697; rs7826586; rs11783470; rs2702976; rs2702982; rs2741224; rs12335293; rs2739160; rs34413321; rs3958178; rs35473851; rs28659831; rs33960269; rs35664939; rs1882978; rs2979050; rs10536232; rs35313509; rs853315; rs16904817; rs10706012; rs7836320; rs2702984; rs10567770; rs33939827; rs10101897; rs35583800; rs33910321; rs35619992; rs10532987; rs5895164; rs11436640; rs2739179; rs6999184; rs2687844; rs12680666; rs34440378; rs35102598; rs34760590; rs35993480; rs5895169; rs35112762; rs10683644; rs2958703; rs2739147; rs10599394; rs860472; rs2687821; rs13267793; rs35551180; rs1963138; rs2703001; rs34075260; rs34057484; rs28758899; rs28441030; rs6986262; rs34171048; rs28406375; rs28433340; rs6993571; rs34667104; rs34691628; rs35639331; rs879816; rs36065345; rs28405864; rs35468299; rs35606126; rs7460288; rs7011285; rs4316133; rs2958685; rs940076; rs35717199; rs33939013; rs11780782; rs36094625; rs10699743; rs34164866; rs10639956; rs28475483; rs11268257; rs10618253; rs34218497; rs35334722; rs16904818; rs2958698; rs35143972; rs5895166; rs34749093; rs34587713; rs35656634; rs34943147; rs33935978; rs7813333; rs35836924; rs11320050; rs10108500; rs13269733; rs10553390; rs12548839; rs2702981; rs2979044; rs10101716; rs2702977; rs2687835; rs34981034; rs33953992; rs11325505; rs35531314; rs16904804; rs7823660; rs34389272; rs11404754; rs35290286; rs853314; rs35375818; rs28372516; rs11992137; rs33951544; rs3837188; rs34003114; rs34683713; rs35802760; rs35601099; rs35663551; rs34907891; rs2979041; rs34323965; rs11394917; rs12680647; rs3946466; rs5895175; rs2958702; rs2739146; rs34657175; rs7844893; rs1882979; rs35758143; rs6995181; rs5895168; rs34384392; rs36011461; rs2293998; rs10539476; rs11780113; rs13249946; rs2739178; rs180201; rs35336483; rs10532986; rs17621034; rs2739150; rs34016052; rs34726287; rs1134547; rs35340418; rs28697159; rs4736617; rs3992995; rs34362315; rs7841083; rs2702986; rs35983466; rs4736427; rs35000085; rs34511753; rs34029436; rs35779760; rs7829320; rs28579253; rs2981294; rs34781226; rs28428818; rs10956685; rs2739055; rs11268816; rs11316187; rs36223872; rs35432641; rs28719581; rs28393420; rs12676508; rs7820791; rs34713535; rs13266643; rs34290542; rs35286448; rs3076090; rs28452373; rs34965607; rs2958695; rs34352106; rs36011474; rs7835552; rs34419422; rs909360; rs34115098; rs3892190; rs34527875; rs34207784; rs2958690; rs12548841; rs853312; rs7012120; rs34649941; rs35056813; rs853324; rs2979047; rs34300693; rs12541293; rs7016620; rs34401566; rs34528002; rs180209; rs35431905; rs10624943; rs10086291; rs2981293; rs2958689; rs853313; rs3832581; rs13439049; rs35340140; rs28402248; rs35292436; rs861203; rs853299; rs11395047; rs11335158; rs10639958; rs33985805; rs11778569; rs35975996; rs34975986; rs35140466; rs10092528; rs13260781; rs35977562; rs34409761; rs35755717; rs34906603; rs35729450; rs35149312; rs35275167; rs35676595; rs16904819; rs2294001; rs35215721; rs1811812; rs4736632; rs10660502; rs34542708; rs940077; rs36225951; rs2958682; rs36002632; rs13254863; rs33990330; rs7840281; rs2979024; rs35079765; rs6992619; rs11997110; rs16904826; rs28445135; rs12547060; rs2702980; rs28727293; rs2979031; rs2467990; rs34843766; rs34669143; rs6989555; rs16904820; rs7461513; rs28654406; rs35917695; rs10094088; rs36221525; rs33910057; rs34799712; rs34475728; rs34861244; rs35457246; rs2294004; rs34338140; rs7011227; rs33972433; rs34300442; rs5895167; rs28654846; rs34989595; rs13263197; rs4576410; rs35944432; rs3992994; rs10095026; rs35636762; rs35059390; rs34637329; rs28620579; rs12680667; rs34249106; rs10650506; rs34971750; rs2739056; rs28680551; rs28573183; rs34904146; rs10112059; rs16904831; rs35584041; rs35769648; rs7015805; rs28547062; rs34581780; rs34569436; rs10570581; rs16904834; rs28640053; rs28384408; rs11269191; rs34691975; rs11277781; rs35468381; rs10102363; rs36110471; rs11988144; rs16904787; rs35844025; rs2958696; rs35542042; rs7828465; rs35161639; rs2739052; rs34491481; rs11359047; rs28758516; rs11786128; rs28540916; rs2979043; rs34420477; rs4404893; rs34052396; rs10639957; rs35870007; rs180214; rs36055972; rs2958701; rs35565593; rs34432553; rs34839909; rs35644874; rs34047530; rs2739167; rs6994282; rs34473243; rs36059290; rs34840168; rs35683386; rs34949600; rs2958675; rs7012887; rs28582446; rs11272738; rs11779877; rs36056438; rs4330673; rs5895163; rs35515477; rs34393101; rs1882977; rs853325; rs34619069; rs5895174; rs180218; rs36223983; rs35376892; rs180203; rs33977608; rs35235993; rs34690484; rs34220859; rs35833882; rs7013696; rs3758109; rs35213262; rs13278046; rs34036189; rs34079651; rs12674632; rs35128090; rs35996460; rs2958691; rs853320; rs34258994; rs33942146; rs35196927; rs2702975; rs454222; rs28611783; rs180199; rs180200; rs180198; rs34146730; rs3834381; rs180197; rs180196; rs3758116; rs436505; rs34276475; rs34933516; rs35054972; rs1006197; rs10087449; rs10093650; rs10093995; rs10096073; rs10099615; rs10106075; rs10107766; rs1010873; rs1049528; rs1049529; rs1049535; rs10755938; rs10808603; rs10808604; rs10956690; rs10956691; rs10956692; rs1122414; rs1123672; rs1124527; rs11990500; rs11993576; rs12164182; rs12549029; rs1403494; rs1533910; rs16904757; rs16904758; rs16904759; rs16904760; rs16904807; rs16904808; rs16904810; rs16904814; rs17622362; rs17683567; rs17695552; rs1916271; rs1916272; rs1916273; rs2037541; rs2069556; rs2069569; rs2142377; rs2205450; rs2205451; rs2244060; rs2249272; rs2252553; rs2252681; rs2252696; rs2252706; rs2252805; rs2252807; rs2252813; rs2252917; rs2253035; rs2256366; rs2293208; rs2403912; rs2461800; rs2467992; rs2467993; rs2472546; rs2472547; rs2472548; rs2687836; rs2687837; rs2702966; rs2702967; rs2702968; rs2702970; rs2702971; rs2702972; rs2702996; rs2703000; rs2703012; rs2739136; rs2739138; rs2739153; rs2739181; rs2739182; rs2741192; rs2741194; rs2741195; rs2741197; rs2741199; rs2741200; rs2741202; rs2777; rs2896691; rs2958699; rs2979046; rs3739266; rs3739268; rs3758110; rs3779965; rs4370513; rs4430072; rs4458855; rs4486183; rs4489309; rs4489310; rs4492356; rs4736436; rs4736618; rs4736619; rs4736620; rs4736634; rs6471110; rs6983548; rs7017140; rs7817183; rs7819747; rs880073; rs880075; rs883685; rs940079; rs954591; rs9942754

# Macromolecular_Interacting_Partner_4_General_References:
3595599; 9186272; 3971976; 3681978; 2991855; 11124863; 10524569; 1639210; 2914619; 8269951; 7793989; 8615697; 8797845; 2760035; 10448091; 12387814; 8094490; 10199792

# Macromolecular_Interacting_Partner_4_References:
2818564; 67547; 9506870; 9827658

End of HMDB00021

Beginning of HMDB00022
# Accession_No:
HMDB00022

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-22 12:48:38

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
3-Methoxytyramine

# Description:
The O-methylated derivative of dopamine. Dopamine is methylated by catechol-O-methyltransferase (COMT) to make 3-Methoxytyramine.  This compound can be broken down to homovanillic acid by monoamine oxidase and aldehyde dehydrogenase.  Elevated concentrations of this compound are indicated for a variety of brain and carcinoid tumors as well as certain mental disorders. 

# Synonyms:
3-Methoxy-4-hydroxyphenylethyl amine; 3-Methoxytyramine; 3-O-methyldopamine; 4-(2-Aminoethyl)-2-methoxyphenol; 4-(2-amino-ethyl)-2-methoxy-phenol; 4-(2-aminoethyl)-2-methoxy-Phenol; 5-(2-aminoethyl)guaiacol

# Chemical_IUPAC_Name:
4-(2-aminoethyl)-2-methoxy-phenol

# Chemical_Formula:
C9H13NO2

# Chemical_Structure:
tbl_chemical:::HMDB00022_ZOOM.png:::119283134837150354

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00022_THUMB.png:::119283134639189868

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Heterocyclic Amines; Catecholamines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
phenol or hydroxyhetarene; alkyl aryl ether; primary amine; primary aliphatic amine (alkylamine); aromatic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
167.09464

# Molecular_Weight_Avg:
167.20502

# Smiles_String_isomeric:
COC1=C(O)C=CC(CCN)=C1

# Smiles_String_canonical:
COC1=C(O)C=CC(CCN)=C1

# KEGG_Compound_ID:
C05587

# BioCyc_ID:
Not Available

# PubChem_CID:
1669

# PubChem_SID:
3885186; 6385644; 10526958; 11111459; 3137085; 7912; 563328; 10324234; 8151227

# OMIM_ID:
Not Available

# Metagene_ID:
AROMATIC L-AMINO ACID DECARBOXYLASE DEFICIENCY: 354; MONOAMINE OXIDASE-A DEFICIENCY (MAO-A): 446

# BiGG_ID:
46076

# Wikipedia_ID:
Not Available

# METLIN_ID:
5094

# Ref_ID:
2927387; 7004664; 262188; 6749220; 12138004; 4073504; 12649306; 15556832; 12105105; 7251775; 4281061; 872373; 3434205; 15542730; 15120096

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
554-52-9

# InChI:
InChI=1/C9H13NO2/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,6,11H,4-5,10H2,1H3

# Synthesis_Reference:
 Journal of the American Chemical Society  (1950),  72  2781-2.

# Melting_Point:
Not Available

# Melting_Point_predicted:
95.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
1000.0 mg/mL [MEYLAN,WM et al. (1996)]; 5.36 mg/mL [Predicted by ALOGPS]

# phys_charge:
1

# State:
Solid

# LogP:
-0.08 [SANGSTER (1994)]

# LogP_predicted:
-0.03 [Predicted by ALOGPS]; 0.8 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::3-Methoxytyramine hydrochloride.pdf:::1132562190264389390

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::3-Methoxytyramine.mol:::1132723801843603089

# SDF_File_[Text]:
tbl_chemical:::HMDB00022.sdf:::119283134255885631

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00022.pdb:::119283134471649943

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041029_P00_03_HW_1DP_presat_expanded_2.gif:::114168243533697090

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041029_P00_03_HW_1DP_presat.zip:::117512428532887921

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041029_P00_03_HW_1DP_Assigned.png:::114659163726823364

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041029_P00_03_HW_2DHSQC_619.png:::114781137104939439

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041029_P00_03_HW_2DHSQC_619.zip:::114781137107746152

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041029_P00_03_HW_2DHSQC_619_Assigned.png:::116180789755556652

# Predicted_H_NMR_Spectrum:
tbl_chemical:::3-Methoxytyramine.gif:::1132732099343905484

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00022_peaks.txt:::1156309491433949289

# Predicted_C_NMR_Spectrum:
tbl_chemical:::3-Methoxytyramine_C.gif:::1132737658338315089

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00022_peaks.txt:::1156310683314712352

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00022L.png:::117555261815580220; Medium Energy:tbl_ms:::HMDB00022M.png:::117555266932443287; High Energy:tbl_ms:::HMDB00022H.png:::117555270825292267

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Brain; Most Tissues

# deuterated:
No

# Biofluid_Location:
Blood

# Concentration_[Normal]:
Blood	0.00003	umol/L	Adult:>18_yrs_old	Both	Normal	12649306
Blood	0.0025 (0.0016-0.0029)	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Autism; Carcinoid Tumour; Neuroblastoma; Pheochromocytoma

# Pathway_Names:
Tyrosine metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00350

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5393

# Metabolic_Enzyme_1_Name:
Amine oxidase [flavin-containing] B

# Metabolic_Enzyme_1_Synonyms:
Monoamine oxidase type B; MAO-B

# Metabolic_Enzyme_1_Gene_Name:
MAOB

# Metabolic_Enzyme_1_Protein_Sequence:
>Amine oxidase flavincontaining 
BMSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGS
YVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFW
RTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHE
VSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYID
QTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIV
YYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEE
RLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVD
RIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITT
TFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV

# Metabolic_Enzyme_1_Number_of_Residues:
520

# Metabolic_Enzyme_1_Molecular_Weight:
58764

# Metabolic_Enzyme_1_Theoretical_pI:
7.55

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine

# Metabolic_Enzyme_1_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_1_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01593:Amino_oxidase

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
490-516

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.4.3.4

# Metabolic_Enzyme_1_GenBank_ID_Protein:
398415

# Metabolic_Enzyme_1_SwissProt_ID:
AOFB_HUMAN (P27338)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
MAOB

# Metabolic_Enzyme_1_Geneatlas_id:
MAOB

# Metabolic_Enzyme_1_hgnc_id:
HGNC:6834

# Metabolic_Enzyme_1_PDB_ID:
2BK3

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type IV membrane protein; cytoplasmic side

# Metabolic_Enzyme_1_Gene_Sequence:
>1560 bp
ATGAGCAACAAATGCGACGTGGTCGTGGTGGGGGGCGGCATCTCAGGTATGGCAGCAGCC
AAACTTCTGCATGACTCTGGACTGAATGTGGTTGTTCTGGAAGCCCGGGACCGTGTGGGA
GGCAGGACTTACACTCTTAGGAACCAAAAGGTTAAATATGTGGACCTTGGAGGATCCTAT
GTTGGACCAACCCAGAATCGTATCTTGAGATTAGCCAAGGAGCTAGGATTGGAGACCTAC
AAAGTGAATGAGGTTGAGCGTCTGATCCACCATGTAAAGGGCAAATCATACCCCTTCAGG
GGGCCATTCCCACCTGTATGGAATCCAATTACCTACTTAGATCATAACAACTTTTGGAGG
ACAATGGATGACATGGGGCGAGAGATTCCGAGTGATGCCCCATGGAAGGCTCCCCTTGCA
GAAGAGTGGGACAACATGACAATGAAGGAGCTACTGGACAAGCTCTGCTGGACTGAATCT
GCAAAGCAGCTTGCCACTCTCTTTGTGAACCTGTGTGTCACTGCAGAGACCCATGAGGTC
TCTGCTCTCTGGTTCCTGTGGTATGTGAAGCAGTGTGGAGGCACAACAAGAATCATCTCG
ACAACAAATGGAGGACAGGAGAGGAAATTTGTGGGCGGATCTGGTCAAGTGAGTGAGCGG
ATAATGGACCTCCTTGGAGACCGAGTGAAGCTGGAGAGGCCTGTGATCTACATTGACCAG
ACAAGAGAAAATGTCCTTGTGGAGACCCTAAACCATGAGATGTATGAGGCTAAATATGTG
ATTAGTGCTATTCCTCCTACTCTGGGCATGAAGATTCACTTCAATCCCCCTCTGCCAATG
ATGAGAAACCAGATGATCACTCGTGTGCCTTTGGGTTCAGTCATCAAGTGTATAGTTTAT
TATAAAGAGCCTTTCTGGAGGAAAAAGGATTACTGTGGAACCATGATTATTGATGGAGAA
GAAGCTCCAGTTGCCTACACGTTGGATGATACCAAACCTGAAGGCAACTATGCTGCCATA
ATGGGATTTATCCTGGCCCACAAAGCCAGAAAACTGGCACGTCTTACCAAAGAGGAAAGG
TTGAAGAAACTTTGTGAACTCTATGCCAAGGTTCTGGGTTCCCTAGAAGCTCTGGAGCCA
GTGCATTATGAAGAAAAGAACTGGTGTGAGGAGCAGTACTCTGGGGGCTGCTACACAACT
TATTTCCCCCCTGGGATCCTGACTCAATATGGAAGGGTTCTACGCCAGCCAGTGGACAGG
ATTTACTTTGCAGGCACCGAGACTGCCACACACTGGAGCGGCTACATGGAGGGGGCTGTA
GAGGCCGGGGAGAGAGCAGCCCGAGAGATCCTGCATGCCATGGGGAAGATTCCAGAGGAT
GAAATCTGGCAGTCAGAACCAGAGTCTGTGGATGTCCCTGCACAGCCCATCACCACCACC
TTTTTGGAGAGACATTTGCCCTCCGTGCCAGGCCTGCTCAGGCTGATTGGATTGACCACC
ATCTTTTCAGCAACGGCTCTTGGCTTCCTGGCCCACAAAAGGGGGCTACTTGTGAGAGTC


# Metabolic_Enzyme_1_GenBank_ID_Gene:
S62734

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_1_Locus:
Xp11.23

# Metabolic_Enzyme_1_SNPs:
rs7879356; rs6324; rs12010260; rs2072745; rs17462; rs3027440; rs7066677; rs3027439; rs1799836; rs3027453; rs2311013; rs3027441; rs5905512; rs3027459; rs2239450; rs2239441; rs7890174; rs5952297; rs3027444; rs5952330; rs7883073; rs5952671; rs6520902; rs2239449; rs6651806; rs3027454; rs7057075; rs12394221; rs2238969; rs12008119; rs7888450; rs12388038; rs2283727; rs12013965; rs17310637; rs12008438; rs5952294; rs5952340; rs12008548; rs12014398; rs1014876; rs3027449; rs2283730; rs2283729; rs5952813; rs6520901; rs5952352; rs2205655; rs10521432; rs6610856; rs12006628; rs3027450; rs6610853; rs2283731; rs3027456; rs2283728; rs9887326; rs5952325; rs3027442; rs7879586; rs12389168; rs3817729; rs12851487; rs5952686; rs3736672; rs2056913; rs1569424; rs7053203; rs2092042; rs7876594; rs12010996; rs3027457; rs9887047; rs3027451; rs17146716; rs7061798; rs3027464; rs6609259; rs3027446; rs736944; rs2239442; rs6609260; rs7067187; rs3027466; rs12558324; rs7888462; rs3027452; rs2092040; rs4824562; rs17146721; rs7884044; rs3027461; rs12389234; rs12007768; rs17244906; rs5952795; rs17146719; rs5905449; rs5952799; rs12394863; rs3027458; rs3027443; rs9698576; rs2092041; rs7892217; rs7061088; rs12689868; rs7067027; rs3027448; rs12558614; rs7057957; rs1040398; rs1040400; rs3027435; rs1181252; rs1040399; rs3027434; rs17852046; rs12850496; rs12845773; rs17856663; rs12845783; rs5952696; rs3191382; rs1181251; rs35285191; rs1051000; rs1803940; rs3027438; rs1051003; rs1050990; rs4339787; rs28530533; rs3027468; rs5952754; rs5952690; rs12558961; rs12852985; rs34468176; rs2311012; rs5905428; rs34165496; rs34825602; rs7892394; rs5952812; rs11091124; rs5906017; rs28522648; rs5952677; rs11282093; rs5906045; rs3838196; rs3027455; rs28667959; rs3027463; rs35676271; rs12841775; rs35574902; rs3027447; rs28657720; rs6610848; rs28531879; rs4824563; rs6610854; rs7060566; rs12396954; rs3027469; rs35687186; rs5952736; rs35375952; rs7057164; rs34716997; rs7062993; rs7063171; rs11412800; rs6651629; rs12845848; rs12853563; rs12012179; rs28368734; rs12115950; rs35968321; rs3027460; rs12394356; rs35439218; rs36085366; rs34265248; rs35762562; rs2239451; rs34292051; rs3027445; rs11320541; rs10481834; rs12845568; rs4592179; rs3216388; rs34945383; rs34220802; rs6610855; rs34261731; rs28485908; rs7888867; rs11431011; rs4071606; rs12390352; rs10567219; rs35520175; rs28527225; rs36068670; rs5952687; rs7888857; rs5952777; rs34822523; rs12010683; rs7883563; rs5952814; rs36209687; rs5952751; rs2238970; rs5952744; rs35797631; rs12389578; rs7474005; rs3027465; rs5952768; rs5906031; rs28636832; rs34252524; rs7058426; rs12391346; rs12689072; rs35943983; rs12395246; rs11414517; rs3027467; rs12013925; rs3736671; rs28421767; rs7058949; rs35634965; rs28754429; rs1894610; rs36102775; rs9887081; rs5952817; rs12855578; rs10658111; rs7062575; rs4620438; rs28568938; rs35291347; rs11797733; rs35054600; rs5952335; rs3027462; rs5952712; rs34752122; rs3054011; rs3027437; rs28577261; rs3027433; rs3761584; rs3027436; rs3027432; rs12558036; rs3027418; rs3027419; rs3027420; rs3027421; rs3027423; rs3027424; rs3027425; rs3027426; rs3027427; rs3027428; rs3027429; rs3027430; rs3027431; rs4351544; rs7884135; rs7890899

# Metabolic_Enzyme_1_General_References:
2023912; 3387449; 8515265; 1432104; 11049757; 11753429

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5401

# Metabolic_Enzyme_2_Name:
Amine oxidase [flavin-containing] A

# Metabolic_Enzyme_2_Synonyms:
Monoamine oxidase type A; MAO-A

# Metabolic_Enzyme_2_Gene_Name:
MAOA

# Metabolic_Enzyme_2_Protein_Sequence:
>Amine oxidase flavincontaining 
AMENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEH
VDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPI
AYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVN
INVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVK
LNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLP
MGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKAD
RLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQY
GRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESK
DVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS

# Metabolic_Enzyme_2_Number_of_Residues:
527

# Metabolic_Enzyme_2_Molecular_Weight:
59682

# Metabolic_Enzyme_2_Theoretical_pI:
7.96

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine

# Metabolic_Enzyme_2_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_2_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01593:Amino_oxidase

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
498-518

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.4.3.4

# Metabolic_Enzyme_2_GenBank_ID_Protein:
187353

# Metabolic_Enzyme_2_SwissProt_ID:
AOFA_HUMAN (P21397)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
MAOA

# Metabolic_Enzyme_2_Geneatlas_id:
MAOA

# Metabolic_Enzyme_2_hgnc_id:
HGNC:6833

# Metabolic_Enzyme_2_PDB_ID:
1O5W

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type IV membrane protein; cytoplasmic side

# Metabolic_Enzyme_2_Gene_Sequence:
>1584 bp
ATGGAGAATCAAGAGAAGGCGAGTATCGCGGGCCACATGTTCGACGTAGTCGTGATCGGA
GGTGGCATTTCAGGACTATCTGCTGCCAAACTCTTGACTGAATATGGCGTTAGTGTTTTG
GTTTTAGAAGCTCGGGACAGGGTTGGAGGAAGAACATATACTATAAGGAATGAGCATGTT
GATTACGTAGATGTTGGTGGAGCTTATGTGGGACCAACCCAAAACAGAATCTTACGCTTG
TCTAAGGAGCTGGGCATAGAGACTTACAAAGTGAATGTCAGTGAGCGTCTCGTTCAATAT
GTCAAGGGGAAAACATATCCATTTCGGGGCGCCTTTCCACCAGTATGGAATCCCATTGCA
TATTTGGATTACAATAATCTGTGGAGGACAATAGATAACATGGGGAAGGAGATTCCAACT
GATGCACCCTGGGAGGCTCAACATGCTGACAAATGGGACAAAATGACCATGAAAGAGCTC
ATTGACAAAATCTGCTGGACAAAGACTGCTAGGCGGTTTGCTTATCTTTTTGTGAATATC
AATGTGACCTCTGAGCCTCACGAAGTGTCTGCCCTGTGGTTCTTGTGGTATGTGAAGCAG
TGCGGGGGCACCACTCGGATATTCTCTGTCACCAATGGTGGCCAGGAACGGAAGTTTGTA
GGTGGATCTGGTCAAGTGAGCGAACGGATAATGGACCTCCTCGGAGACCAAGTGAAGCTG
AACCATCCTGTCACTCACGTTGACCAGTCAAGTGACAACATCATCATAGAGACGCTGAAC
CATGAACATTATGAGTGCAAATACGTAATTAATGCGATCCCTCCGACCTTGACTGCCAAG
ATTCACTTCAGACCAGAGCTTCCAGCAGAGAGAAACCAGTTAATTCAGCGGCTTCCAATG
GGAGCTGTCATTAAGTGCATGATGTATTACAAGGAGGCCTTCTGGAAGAAGAAGGATTAC
TGTGGCTGCATGATCATTGAAGATGAAGATGCTCCAATTTCAATAACCTTGGATGACACC
AAGCCTGATGGGTCACTGCCTGCCATCATGGGCTTCATTCTTGCCCGGAAAGCTGATCGA
CTTGCTAAGCTACATAAGGAAATAAGGAAGAAGAAAATCTGTGAGCTCTATGCCAAAGTG
CTGGGATCCCAAGAAGCTTTACATCCAGTGCATTATGAAGAGAAGAACTGGTGTGAGGAG
CAGTACTCTGGGGGCTGCTACACGGCCTACTTCCCTCCTGGGATCATGACTCAATATGGA
AGGGTGATTCGTCAACCCGTGGGCAGGATTTTCTTTGCGGGCACAGAGACTGCCACAAAG
TGGAGCGGCTACATGGAAGGGGCAGTTGAGGCTGGAGAACGAGCAGCTAGGGAGGTCTTA
AATGGTCTCGGGAAGGTGACCGAGAAAGATATCTGGGTACAAGAACCTGAATCAAAGGAC
GTTCCAGCGGTAGAAATCACCCACACCTTCTGGGAAAGGAACCTGCCCTCTGTTTCTGGC
CTGCTGAAGATCATTGGATTTTCCACATCAGTAACTGCCCTGGGGTTTGTGCTGTACAAA
TACAAGCTCCTGCCACGGTCTTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M68840

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_2_Locus:
Xp11.3

# Metabolic_Enzyme_2_SNPs:
rs6323; rs1137070; rs1800464; rs3027407; rs2072743; rs1465107; rs979605; rs3027397; rs2205718; rs979606; rs909525; rs3788862; rs2283725; rs2235186; rs5906883; rs5906974; rs3027403; rs3027405; rs6520894; rs3027401; rs3788863; rs2235185; rs1465108; rs5953385; rs2310883; rs6609250; rs3027398; rs5906938; rs5906729; rs6520897; rs5906893; rs17146683; rs7885398; rs3027402; rs5905702; rs5906957; rs2072744; rs5906915; rs4824498; rs9723729; rs3027406; rs5906973; rs3027400; rs2064697; rs5906914; rs5906901; rs12689575; rs2239448; rs2064696; rs3027392; rs2238968; rs17146660; rs12688067; rs9723711; rs7051042; rs5905859; rs7887158; rs2064698; rs7882699; rs3027399; rs9330645; rs2283724; rs9723795; rs3027404; rs9724332; rs5953210; rs1803986; rs1799835; rs1800466; rs1803987; rs1800465; rs7065428; rs3027408; rs11544798; rs12839550; rs10545588; rs5952250; rs3027394; rs34390290; rs1800659; rs10560402; rs12854463; rs35759188; rs28375424; rs7059300; rs12687961; rs35784967; rs35254233; rs34894015; rs35215664; rs35546327; rs3027396; rs12556694; rs7057038; rs12687974; rs9780693; rs7892282; rs5902323; rs28593700; rs35600375; rs35488042; rs35200424; rs5902326; rs5905823; rs12843650; rs34941362; rs34841794; rs12833632; rs12863636; rs3030071; rs12398290; rs10548364; rs28401570; rs4604608; rs28449781; rs6609256; rs6610845; rs12833929; rs12843268; rs2310884; rs5905830; rs6610846; rs7054032; rs7880230; rs41303697; rs3810709; rs2179098; rs12399572; rs12840448; rs5902324; rs28556796; rs5905812; rs12847449; rs28619059; rs10652560; rs6610837; rs10548363; rs5905418; rs2283726; rs33910552; rs3027395; rs28637527; rs5906971; rs28439389; rs35235270; rs3027393; rs28583596; rs6610842; rs6520893; rs35336176; rs5906913; rs12849959; rs36036121; rs5905822; rs5902325; rs5905809; rs11471949; rs6610834; rs3838195; rs3216387; rs33946653; rs6609255; rs35445276; rs7061874; rs17436054; rs1181275; rs12843533; rs2064070; rs3027409; rs3027410; rs3027414; rs3027415; rs3027416; rs3027417; rs4301558; rs4570308; rs5905613; rs6609257; rs6609258; rs7052785; rs727884

# Metabolic_Enzyme_2_General_References:
3418353; 3387449; 1432104; 8584674; 7519662; 3178846; 2764901; 11812236

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5504

# Metabolic_Enzyme_3_Name:
Catechol O-methyltransferase

# Metabolic_Enzyme_3_Synonyms:
Not Available

# Metabolic_Enzyme_3_Gene_Name:
COMT

# Metabolic_Enzyme_3_Protein_Sequence:
>Catechol Omethyltransferase
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRIL
NHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCG
YSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKY
DVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFE
CTHYQSFLEYREVVDGLEKAIYKGPGSEAGP

# Metabolic_Enzyme_3_Number_of_Residues:
271

# Metabolic_Enzyme_3_Molecular_Weight:
30037

# Metabolic_Enzyme_3_Theoretical_pI:
5.15

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  O-methyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol

# Metabolic_Enzyme_3_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_3_Reaction:
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01596:Methyltransf_3

# Metabolic_Enzyme_3_Signals:
1-32

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.1.1.6

# Metabolic_Enzyme_3_GenBank_ID_Protein:
180920

# Metabolic_Enzyme_3_SwissProt_ID:
COMT_HUMAN (P21964)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
COMT

# Metabolic_Enzyme_3_Geneatlas_id:
COMT

# Metabolic_Enzyme_3_hgnc_id:
HGNC:2228

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Isoform S-COMT:Cytoplasm. Isoform MB-COMT:Cell membrane; single-pass type II membrane protein; extracellular side

# Metabolic_Enzyme_3_Gene_Sequence:
>816 bp
ATGCCGGAGGCCCCGCCTCTGCTGTTGGCAGCTGTGTTGCTGGGCCTGGTGCTGCTGGTG
GTGCTGCTGCTGCTTCTGAGGCACTGGGGCTGGGGCCTGTGCCTTATCGGCTGGAACGAG
TTCATCCTGCAGCCCATCCACAACCTGCTCATGGGTGACACCAAGGAGCAGCGCATCCTG
AACCACGTGCTGCAGCATGCGGAGCCCGGGAACGCACAGAGCGTGCTGGAGGCCATTGAC
ACCTACTGCGAGCAGAAGGAGTGGGCCATGAACGTGGGCGACAAGAAAGGCAAGATCGTG
GACGCCGTGATTCAGGAGCACCAGCCCTCCGTGCTGCTGGAGCTGGGGGCCTACTGTGGC
TACTCAGCTGTGCGCATGGCCCGCCTGCTGTCACCAGGGGCGAGGCTCATCACCATCGAG
ATCAACCCCGACTGTGCCGCCATCACCCAGCGGATGGTGGATTTCGCTGGCGTGAAGGAC
AAGGTCACCCTTGTGGTTGGAGCGTCCCAGGACATCATCCCCCAGCTGAAGAAGAAGTAT
GATGTGGACACACTGGACATGGTCTTCCTCGACCACTGGAAGGACCGGTACCTGCCGGAC
ACGCTTCTCTTGGAGGAATGTGGCCTGCTGCGGAAGGGGACAGTGCTACTGGCTGACAAC
GTGATCTGCCCAGGTGCGCCAGACTTCCTAGCACACGTGCGCGGGAGCAGCTGCTTTGAG
TGCACACACTACCAATCGTTCCTGGAATACAGGGAGGTGGTGGACGGCCTGGAGAAGGCC
ATCTACAAGGGCCCAGGCAGCGAAGCAGGGCCCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M65212

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_3_Locus:
22q11.21-q11.23|22q11.21

# Metabolic_Enzyme_3_SNPs:
rs5031015; rs6267; rs4680; rs13306279; rs13306281; rs6270; rs740602; rs8192488; rs4818; rs769223; rs769224; rs165631; rs4633; rs6269; rs739368; rs165656; rs4646312; rs5992501; rs7287550; rs165722; rs5746849; rs11569715; rs740603; rs9332380; rs7290221; rs174674; rs9332351; rs3810595; rs174675; rs5993887; rs9332361; rs6518593; rs174680; rs9332356; rs5993882; rs11569716; rs3087869; rs9332325; rs174673; rs174678; rs5993883; rs933271; rs9332359; rs165767; rs9332347; rs8185002; rs5993879; rs9332363; rs174691; rs9332332; rs5992500; rs174682; rs9332346; rs13306280; rs362204; rs174688; rs9332342; rs11569717; rs174695; rs5993881; rs7291003; rs1544325; rs9332331; rs3819621; rs174684; rs34798238; rs174677; rs174690; rs9606196; rs174693; rs11912353; rs12053782; rs11913025; rs36111598; rs5993888; rs9332362; rs174685; rs34438295; rs5992499; rs34691071; rs9332357; rs174692; rs9332334; rs3838146; rs9332333; rs9332352; rs35014456; rs35527466; rs35558779; rs11704299; rs9332350; rs6268; rs34450201; rs9680656; rs1055503; rs11912354; rs11089323; rs5993884; rs16982842; rs174679; rs9332353; rs34300220; rs9332358; rs9332360; rs34937293; rs34966851; rs174676; rs16982844; rs5844402; rs9332323; rs35919169; rs174683; rs35777291; rs9332348; rs8140865; rs34686565; rs165737; rs4646315; rs2239393; rs165774; rs9306235; rs740601; rs5993889; rs9306234; rs4646316; rs8140835; rs4646317; rs9332370; rs174697; rs174696; rs9332377; rs4646318; rs1109436; rs9332368; rs3218737; rs34068292; rs9332369; rs9332364; rs9332372; rs9332367; rs9332365; rs4646313; rs34446512; rs34819182; rs174699; rs34234839; rs165895; rs165599; rs9332381; rs35478083; rs36082074; rs11544670; rs4986871; rs11544669; rs165879; rs35791904; rs35788262; rs13054814; rs5992498; rs5748490; rs361698; rs28600912; rs9605040; rs11703339; rs9332319; rs174689; rs9606193; rs5844403; rs9332340; rs34778315; rs11703340; rs5993886; rs14968; rs9332344; rs28621910; rs3081743; rs174681; rs361549; rs35280052; rs361708; rs12167365; rs2004497; rs12170804; rs35357972; rs9332321; rs361574; rs9332328; rs35920235; rs9332337; rs5993880; rs12814; rs9332343; rs11544667; rs9606195; rs9332349; rs11296030; rs5748492; rs9332354; rs34029447; rs35188675; rs3819619; rs8136901; rs35094299; rs9332322; rs28804429; rs174687; rs9332339; rs11912495; rs35617967; rs9332327; rs9332336; rs3841769; rs12167215; rs362253; rs9332338; rs35689277; rs11703069; rs174686; rs12168881; rs9606194; rs361699; rs9332355; rs3081741; rs5746850; rs9617852; rs28565095; rs13306277; rs174698; rs9332373; rs9332374; rs9332366; rs13054356; rs35819339; rs11460758; rs4646314; rs34016976; rs2904564; rs12158230; rs13055002; rs9332375; rs28562050; rs9332378; rs9332371; rs9332376; rs10427781; rs10427983; rs10483103; rs1110477; rs1110478; rs1110479; rs12165997; rs12169508; rs12627876; rs165655; rs165728; rs165815; rs165824; rs165840; rs165849; rs1800749; rs2020917; rs2073749; rs2239394; rs2239395; rs2240713; rs2240714; rs2240715; rs2240718; rs2518823; rs2518824; rs2871047; rs34134422; rs35219372; rs3788319; rs3788320; rs4646310; rs5746846; rs5746847; rs5748483; rs5748484; rs5993890; rs5993891; rs7288060; rs737864; rs737865; rs737866; rs758373; rs8140265; rs887199; rs887200; rs9265; rs9332314; rs9332315; rs9605030; rs9605031; rs9606186; rs9606189; rs9606201; rs9618716

# Metabolic_Enzyme_3_General_References:
1707278; 1847521; 8055944; 1993083; 1765063; 8807664; 10391209

# Metabolic_Enzyme_3_References:
Not Available

End of HMDB00022

Beginning of HMDB00023
# Accession_No:
HMDB00023

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-17 12:35:56

# biospider_lastupdate:
2007-07-12 11:26:36

# Common_Name:
(S)-3-Hydroxyisobutyric acid

# Description:
(S)-3-Hydroxyisobutyric (3-HIBA) acid is an organic acid. 3-HIBA is an intermediate in the metabolic pathways of L-valine and L-thymine amino acids. 3-HIBA plays an important role in the diagnosis of the very rare inherited metabolic diseases 3-hydroxyisobutyric aciduria (OMIM 236795) and methylmalonic semialdehyde dehydrogenase deficiency (OMIM 603178). Patients with 3-hydroxyisobutyric aciduria excrete a significant amount of 3-HIBA not only during the acute stage but also when stable. The deficient enzyme in 3HiB-uria remains unclear. The severity of this disease varies from case to case. Most patients exhibit dysmorphic features, such as a small triangular face, a long philtrum, low set ears and micrognathia (PMID: 113770040, 10686279)

# Synonyms:
(S)-3-Hydroxyisobutyric acid; 2-methyl-L-(+)-Hydracrylate; 2-methyl-L-(+)-Hydracrylic acid; 3-Hydroxy-2-methylpropanoate; 3-Hydroxy-2-methylpropanoic acid; 3-Hydroxyisobutyrate; 3-Hydroxyisobutyric acid; 3-hydroxy-2-methyl-(S)-Propanoate; 3-hydroxy-2-methyl-(S)-Propanoic acid; 3-hydroxy-isobutyrate

# Chemical_IUPAC_Name:
3-hydroxy-2-methyl-propanoic acid

# Chemical_Formula:
C4H8O3

# Chemical_Structure:
tbl_chemical:::HMDB00023_ZOOM.png:::119283135776224956

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00023_THUMB.png:::119283135587577041

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary alcohol; carboxylic acid

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
104.04735

# Molecular_Weight_Avg:
104.10452

# Smiles_String_isomeric:
CC(CO)C(O)=O

# Smiles_String_canonical:
CC(CO)C(O)=O

# KEGG_Compound_ID:
C01188

# BioCyc_ID:
3-HYDROXY-ISOBUTYRATE

# PubChem_CID:
87

# PubChem_SID:
1995; 6820032; 8143904; 8150449; 4414; 766462

# OMIM_ID:
236795; 250620

# Metagene_ID:
3-HYDROXYISOBUTYRIC ACIDURIA: 307; KETOSIS, UNSPECIFIC [DD]: 279; METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY: 485

# BiGG_ID:
37034

# Wikipedia_ID:
Not Available

# METLIN_ID:
483

# Ref_ID:
2104971; 2732286; 10686279; 1625099; 126826; 8412012

# ChEBI_ID:
18064

# CAS_Registry_Number:
2068-83-9

# InChI:
InChI=1/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)

# Synthesis_Reference:
D(-)-b-Hydroxyisobutyric acid by fermentation.     Robison, Robert S.; Szarka, Laszlo J.  (E. R. Squibb and Sons, Inc., USA).    Eur. Pat. Appl.  (1985),     19 pp.

# Melting_Point:
Not Available

# Melting_Point_predicted:
25.6 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
571.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-0.7 [Predicted by PubChem via XLOGP]; -0.47 [Predicted by ALOGPS]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00023.mol:::118426119867771865

# SDF_File_[Text]:
tbl_chemical:::HMDB00023.sdf:::119283135260874438

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00023.pdb:::119283135424980194

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::HMDB00023.zip:::118428001166367156

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041201_S02_38_BA_Assigned.png:::118428001171645855

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::3-Hydroxyisobutyric acid.gif:::113273209956223339

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00023_peaks.txt:::115630949244340696

# Predicted_C_NMR_Spectrum:
tbl_chemical:::3-Hydroxyisobutyric acid_C.gif:::1132737659029445305

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00023_peaks.txt:::1156310684338511979

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00023.png:::1165434255636916906; Medium Energy:tbl_ms:::HMDB00023.png:::1165434125921946969; High Energy:tbl_ms:::HMDB00023.png:::1165434169814186494

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; mitochondria

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Blood; CSF

# Concentration_[Normal]:
Blood	20.0 (4.0-48.0)	umol/L	Adult:>18_yrs_old	Both	Normal	8412012
Cerebrospinal_Fluid(CSF)	18.0 +/- 18.0 (0 - 36)	uM	Adult:>18_yrs_old	N/A	Normal	8412012


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
3-Hydroxyisobutyric Aciduria

# Pathway_Names:
Valine, leucine and isoleucine degradation;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
valine,leucine,and_isoleucine_degradation.jpg;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00280;map00280;map00280

# Pathway_Graphs:
valine,leucine,and_isoleucine_degradation_Graph.jpg;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
valine,leucine,and_isoleucine_degradation.xml;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5632

# Metabolic_Enzyme_1_Name:
3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
HIBADH

# Metabolic_Enzyme_1_Gene_Name:
HIBADH

# Metabolic_Enzyme_1_Protein_Sequence:
>3hydroxyisobutyrate dehydrogenase, mitochondrial precursor
MAASLRLLGAASGLRYWSRRLRPAAGSFAAVCSRSVASKTPVGFIGLGNMGNPMAKNLMK
HGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGIL
KKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVED
EFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGLDPKLL
AKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGTTLMAKDLGLAQDSATSTKSPI
LLGSLAHQIYRMMCAKGYSKKDFSSVFQFLREEETF

# Metabolic_Enzyme_1_Number_of_Residues:
336

# Metabolic_Enzyme_1_Molecular_Weight:
35329

# Metabolic_Enzyme_1_Theoretical_pI:
8.26

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
Function:  phosphogluconate dehydrogenase (decarboxylating) activity
Function:  phosphogluconate dehydrogenase (decarboxylating) activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  3-hydroxyisobutyrate dehydrogenase activity
 ||
>>>
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  pentose-phosphate shunt
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  branched chain family amino acid metabolism
Process:  valine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
3-hydroxy-2-methylpropanoate + NAD(+) = 2- methyl-3-oxopropanoate + NADH

# Metabolic_Enzyme_1_Pathway:
map00280  Valine, leucine and isoleucine degradation

# Metabolic_Enzyme_1_Reaction:
3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF03446:NAD_binding_2

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.1.1.31

# Metabolic_Enzyme_1_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_1_SwissProt_ID:
3HIDH_HUMAN (P31937)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
HIBADH

# Metabolic_Enzyme_1_Geneatlas_id:
HIBADH

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4907

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_1_Gene_Sequence:
Not Available

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AC007130

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_1_Locus:
7p15.2

# Metabolic_Enzyme_1_SNPs:
rs11550134; rs3735571; rs1052741; rs1052724; rs2391443; rs2160125; rs961725; rs1980330; rs978447; rs1014373; rs2391453; rs1009252; rs723699; rs974883; rs2391447; rs1980329; rs1404282; rs1524532; rs1851913; rs42088; rs42085; rs7806812; rs961724; rs1524529; rs4719902; rs7806415; rs1014372; rs6945993; rs6958747; rs1030003; rs7783447; rs1357760; rs12155430; rs7789788; rs12670250; rs7779990; rs6970104; rs12667235; rs10951175; rs6961867; rs10486548; rs6462037; rs1524527; rs6415252; rs1554641; rs2391446; rs10951176; rs4348389; rs4140899; rs6462034; rs1524530; rs4722727; rs1880370; rs10951172; rs42087; rs6974387; rs6462038; rs2192559; rs6974932; rs1524533; rs12700830; rs13244903; rs999491; rs12700817; rs4722726; rs759270; rs6964190; rs4722719; rs2893292; rs12667610; rs9639552; rs759268; rs6462039; rs7808275; rs6415251; rs961723; rs12540276; rs1404276; rs6960834; rs2080245; rs11979446; rs6947004; rs6946075; rs6947731; rs6462033; rs11762056; rs1015750; rs1608664; rs11761718; rs17607303; rs2041714; rs12665991; rs12700829; rs12539472; rs6963421; rs13227873; rs6462029; rs4719901; rs11772163; rs12667470; rs10486553; rs12537499; rs6980382; rs723700; rs7778320; rs4722728; rs759272; rs2110524; rs11761773; rs12670415; rs12674175; rs10486550; rs12671723; rs1115346; rs12535844; rs1229605; rs12700825; rs10447552; rs6957378; rs7455882; rs11982323; rs6946305; rs6462031; rs10486549; rs2391451; rs12164139; rs759269; rs13242248; rs6955074; rs1009253; rs3735570; rs16874305; rs17155443; rs2391445; rs7786973; rs42086; rs1000317; rs2098315; rs6948814; rs1851911; rs11764624; rs1608663; rs6943883; rs6959495; rs2391444; rs7809748; rs1404278; rs2391452; rs7788376; rs11764753; rs12530626; rs11764419; rs6963585; rs12668430; rs10486547; rs986706; rs2110526; rs6954905; rs4722724; rs1015265; rs10951174; rs17155450; rs12111584; rs13236908; rs17680908; rs12670771; rs6944610; rs11973492; rs4722720; rs7796520; rs7794292; rs6462036; rs16874328; rs17155494; rs12700824; rs16874321; rs2110527; rs17682155; rs17155546; rs1005128; rs10081338; rs1115347; rs13227574; rs11972463; rs4722717; rs6958467; rs17155460; rs7778454; rs1524531; rs12700826; rs10807841; rs3925338; rs1524526; rs962925; rs4722725; rs11767188; rs6959865; rs2391450; rs12112192; rs12700823; rs6976178; rs10233212; rs17155501; rs12672811; rs2110528; rs4719899; rs10266854; rs17155498; rs2391442; rs7806605; rs12700815; rs7780431; rs7790498; rs769368; rs10951171; rs6966587; rs2041715; rs4722718; rs12531518; rs1986243; rs17155505; rs17155537; rs2037638; rs1229604; rs1851912; rs12700819; rs11762342; rs7795207; rs12540063; rs13241127; rs17155465; rs12534603; rs9639553; rs759271; rs10256159; rs13227521; rs13232561; rs12700813; rs6651068; rs12673949; rs6944025; rs16874319; rs17607155; rs17683094; rs2391439; rs12700828; rs6959126; rs11773033; rs2098316; rs13246464; rs2391454; rs4719903; rs16874325; rs1986215; rs7805086; rs6975900; rs12672823; rs6462032; rs1880371; rs13231645; rs11526176; rs17155513; rs11971346; rs2391449; rs2391438; rs10951173; rs6948460; rs2080246; rs9639560; rs9639559; rs12700821; rs12113735; rs17155566; rs7811436; rs10486552; rs17607608; rs17155525; rs7456595; rs12531952; rs42089; rs4719898; rs3847001; rs6956484; rs6961429; rs13242238; rs6969043; rs6462027; rs11971886; rs4719897; rs6968631; rs6969207; rs35454595; rs35946970; rs11408852; rs5009225; rs6962817; rs13307738; rs3905446; rs5883095; rs12531947; rs34071982; rs35779560; rs11343650; rs35467427; rs1123445; rs17155541; rs3922286; rs34698857; rs34125931; rs13228040; rs35461964; rs35124908; rs3072888; rs12674403; rs33933634; rs2391437; rs33983898; rs13229467; rs12113593; rs35272178; rs34536886; rs35083158; rs34764301; rs36091381; rs34019098; rs9639551; rs35733358; rs17609417; rs35213965; rs35969430; rs3072850; rs10591084; rs34920159; rs34504304; rs35121197; rs12055920; rs10244508; rs34950198; rs34206933; rs5883091; rs41326151; rs11274075; rs6975597; rs10637650; rs35359839; rs3072898; rs34491908; rs13234803; rs34640888; rs35477948; rs11289715; rs10628041; rs13240752; rs34453577; rs1229606; rs5883094; rs7777523; rs11763449; rs6955472; rs34329289; rs35840171; rs35662263; rs3072901; rs34708981; rs1404277; rs35465476; rs35115558; rs35881985; rs34906269; rs28461898; rs35925990; rs5883089; rs6150044; rs11520704; rs34360572; rs1030002; rs7807597; rs34065248; rs4495321; rs10544725; rs11344706; rs4000635; rs35429121; rs11442513; rs34275714; rs13228144; rs13240957; rs35733141; rs28547285; rs13228800; rs35347183; rs10280216; rs35651615; rs3072889; rs7456657; rs35970473; rs6944455; rs1554640; rs2391448; rs5883090; rs35937817; rs12155431; rs4719900; rs13307528; rs35870816; rs36140938; rs34311576; rs35711061; rs34173110; rs35114679; rs11269935; rs35977021; rs35562626; rs3072856; rs11355038; rs28429439; rs6980386; rs34169544; rs17610547; rs35642553; rs5883087; rs34886410; rs7456656; rs10240428; rs35804923; rs11274711; rs7459009; rs11386502; rs13242241; rs13310486; rs35283108; rs34357333; rs10642707; rs35473122; rs34459017; rs2391441; rs5883097; rs13226102; rs13247662; rs34923508; rs3072887; rs5883100; rs33968860; rs35850169; rs6966091; rs1030001; rs28539571; rs13229579; rs3072924; rs7457947; rs34415273; rs13310749; rs34400365; rs35816118; rs12700822; rs34236612; rs34036272; rs2391440; rs35344159; rs34707991; rs34748212; rs35402898; rs34552407; rs35249568; rs13310466; rs2110525; rs11434769; rs5883088; rs35812055; rs10569030; rs35240005; rs36095835; rs1851909; rs12539707; rs6150043; rs1005418; rs34038351; rs5883093; rs35635917; rs35672101; rs28416309; rs6956238; rs11402963; rs34638402; rs1235364; rs28433694; rs35475209; rs35820093; rs34444109; rs10264586; rs5883096; rs34784239; rs7803464; rs5883099; rs34906094; rs1524525; rs7782422; rs10629006; rs35908911; rs6950698; rs35149329; rs17607043; rs10586738; rs35724262; rs12700814; rs36069602; rs35771883; rs34905189; rs11356347; rs11317913; rs3072931; rs34064591; rs34450880; rs4478473; rs35131335; rs10081339; rs11460373; rs34062015; rs13228142; rs35572534; rs3915090; rs34437775; rs7777507; rs34453559; rs1229607; rs34081161; rs34847398; rs10553105; rs6150042; rs11411482; rs13308974; rs5883092; rs12155440; rs28503587; rs34051183; rs6946582; rs35442974; rs34578407; rs10248276; rs35914219; rs11765792; rs34735996; rs34807722; rs10272298; rs11305053; rs12700831; rs35105727; rs28372805; rs35871970; rs10951169; rs1111647; rs11768533; rs11771265; rs12112727; rs12234338; rs12534474; rs12534656; rs13237776; rs13245339; rs16874296; rs2091170; rs2091171; rs4355682; rs6462022; rs6462023; rs6945079; rs6949496; rs6956464; rs6957674; rs6966918; rs6972650; rs6974052; rs7779240; rs7789363; rs940525; rs940526

# Metabolic_Enzyme_1_General_References:
12853948; 8313870

# Metabolic_Enzyme_1_References:
Not Available

End of HMDB00023

Beginning of HMDB00024
# Accession_No:
HMDB00024

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-09-12 10:29:40

# biospider_lastupdate:
2007-09-12 10:34:03

# Common_Name:
3-O-Sulfogalactosylceramide

# Description:
An acidic, sulfated glycosphingolipid, often known as sulfatide.  This lipid occurs in membranes of various cell types, but is found in particularly high concentrations in myelin where it constitutes 3-4% of total membrane lipids.  This lipid is synthesized primarily in the oligodendrocytes in the central nervous system.  Accumulation of this lipid in the lysosomes is a characteristic of metachromatic leukodystrophy, a lysosomal storage disease caused by the deficiency of arylsulfatase A.  Alterations in sulfatide metabolism, trafficking, and homeostasis are present in the earliest clinically recognizable stages of Alzheimer's disease.

# Synonyms:
3'-O-Sulphogalactosylceramide; 3-O-Sulfogalactosylceramide; 3-O-Sulphogalactosylceramide; 3-O-sulfo-beta-D-galactosylceramide; Cerebroside 3-sulfate; Galactosylceramide-sulfate; Galactosylceramidesulfate; Sulfatide; 3-O-sulfo-beta-delta-galactosylceramide

# Chemical_IUPAC_Name:
[(2R,3S,4S,5R,6R)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(E,2S,3R)-3-hydroxy-2-(tetracosanoylamino)octadec-4-enoxy]oxan-4-yl] hydrogen sulfate

# Chemical_Formula:
C48H93NO11S

# Chemical_Structure:
tbl_chemical:::HMDB00024_ZOOM.png:::119283137202581902

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00024_THUMB.png:::119283136982744442

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Lipids; Fatty Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
alkene; secondary alcohol; heterocyclic compound; sulfuric acid monoester; primary alcohol; acetal; secondary carboxylic acid amide

# Taxonomy_Biofunction:
Component of Glycosphingolipid metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
891.64685

# Molecular_Weight_Avg:
892.31714

# Smiles_String_isomeric:
CCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](OS(O)(=O)=O)[C@H]1O)[C@H](O)C=CCCCCCCCCCCCCC

# Smiles_String_canonical:
CCCCCCCCCCCCCCCCCCCCCCCC(=O)NC(COC1OC(CO)C(O)C(OS(O)(=O)=O)C1O)C(O)C=CCCCCCCCCCCCCC

# KEGG_Compound_ID:
C06125

# BioCyc_ID:
GALACTOSYLCERAMIDE-SULFATE

# PubChem_CID:
6451121

# PubChem_SID:
10559604; 639428; 8382

# OMIM_ID:
249900; 256540; 272750

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Sulfatide

# METLIN_ID:
5096

# Ref_ID:
2764035; 1808356; 8455580; 1543730; 10518409; 8080249; 8595716; 6146271; 1970953; 14528918; 15627618; 6119972; 6415115; 6881139; 15772092

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
3688-74-2

# InChI:
InChI=1/C48H93NO11S/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-44(52)49-41(42(51)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2)40-58-48-46(54)47(60-61(55,56)57)45(53)43(39-50)59-48/h35,37,41-43,45-48,50-51,53-54H,3-34,36,38-40H2,1-2H3,(H,49,52)(H,55,56,57)/b37-35+/t41-,42+,43+,45-,46+,47-,48+/m0/s1

# Synthesis_Reference:
Not Available

# Melting_Point:
Not Available

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
2.09e-04 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
6.01 [Predicted by ALOGPS]; 12.1 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00024.mol:::118918508780258965

# SDF_File_[Text]:
tbl_chemical:::HMDB00024.sdf:::119283136221069911

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00024.pdb:::119283136804238429

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::3-O-Sulfogalactosylceramide.gif:::1132732099796898484

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00024_peaks.txt:::1156309493497573058

# Predicted_C_NMR_Spectrum:
tbl_chemical:::3-O-Sulfogalactosylceramide_C.gif:::1132737659710455661

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00024_peaks.txt:::1156310685346651710

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Lysosome; membrane

# Tissue_Location:
Brain; Kidney; Myelin

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	0.205 (0.07-0.34)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	8595716


# Concentration_[Abnormal]:
Urine	12.7 (1.2-24.2)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Metachromatic Leukodystrophy (MLD)	8595716


# Associated_Disorders:
Metachromatic Leukodystrophy (MLD)

# Pathway_Names:
Glycosphingolipid metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00600

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5560

# Metabolic_Enzyme_1_Name:
Arylsulfatase E precursor

# Metabolic_Enzyme_1_Synonyms:
ASE

# Metabolic_Enzyme_1_Gene_Name:
ARSE

# Metabolic_Enzyme_1_Protein_Sequence:
>Arylsulfatase E precursor
MLHLHHSCLCFRSWLPAMLAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNT
MRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASG
GLPTNETTFAKILKEKGYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGD
CARWELSEKRVNLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLAS
SYFVGALIVHADCFLMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHV
HIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLEN
QLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVR
LAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFV
TPVFQPEGAGACYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHILTPASEPVFYQVMER
VQQAVWEHQRTLSPVPLQLDRLGNIWRPWLQPCCGPFPLCWCLREDDPQ

# Metabolic_Enzyme_1_Number_of_Residues:
589

# Metabolic_Enzyme_1_Molecular_Weight:
65670

# Metabolic_Enzyme_1_Theoretical_pI:
6.96

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  sulfuric ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates

# Metabolic_Enzyme_1_Pathway:
Not Available

# Metabolic_Enzyme_1_Reaction:
Not Available

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00884:Sulfatase

# Metabolic_Enzyme_1_Signals:
1-31

# Metabolic_Enzyme_1_Transmembrane_Regions:
200-222; 227-249; 289-311

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.1.6.1

# Metabolic_Enzyme_1_GenBank_ID_Protein:
791004

# Metabolic_Enzyme_1_SwissProt_ID:
ARSE_HUMAN (P51690)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ARSE

# Metabolic_Enzyme_1_Geneatlas_id:
ARSE

# Metabolic_Enzyme_1_hgnc_id:
HGNC:719

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Golgi apparatus; Golgi stack

# Metabolic_Enzyme_1_Gene_Sequence:
>1770 bp
ATGTTACATCTGCACCATTCTTGTTTGTGTTTCAGGAGCTGGCTGCCAGCGATGCTCGCT
GTACTGCTAAGTTTGGCACCATCAGCTTCCAGCGACATTTCCGCCTCCCGACCGAACATC
CTTCTTCTGATGGCGGACGACCTTGGCATTGGGGACATTGGCTGCTATGGCAACAACACC
ATGAGGACTCCGAATATTGACCGCCTTGCAGAGGACGGCGTGAAGCTGACCCAACACATC
TCTGCCGCATCTTTGTGCACCCCAAGCAGAGCCGCCTTCCTCACGGGCAGATACCCTGTG
CGATCAGGGATGGTTTCCAGCATTGGTTACCGTGTTCTTCAGTGGACCGGAGCATCTGGA
GGTCTTCCAACAAATGAGACAACTTTTGCAAAAATACTGAAAGAGAAAGGCTATGCCACT
GGACTCATTGGAAAATGGCATCTGGGTCTCAACTGTGAGTCAGCCAGTGATCATTGCCAC
CACCCTCTCCATCATGGCTTTGAGCATTTCTACGGAATGCCTTTCTCCTTGATGGGTGAT
TGCGCCCGCTGGGAACTCTCAGAGAAGCGTGTCAACCTGGAACAAAAACTCAACTTCCTC
TTCCAAGTCCTGGCCTTGGTTGCCCTCACACTGGTAGCAGGGAAGCTCACACACCTGATA
CCCGTCTCGTGGATGCCGGTCATCTGGTCAGCCCTTTCGGCCGTCCTCCTCCTCGCAAGC
TCCTATTTTGTGGGTGCTCTGATTGTCCATGCCGATTGCTTTCTGATGAGAAACCACACC
ATCACGGAGCAGCCCATGTGCTTCCAAAGAACGACACCCCTTATTCTGCAGGAGGTTGCG
TCCTTTCTCAAAAGGAATAAGCATGGGCCTTTCCTCCTCTTTGTTTCCTTTCTACACGTT
CACATCCCTCTTATCACTATGGAGAACTTCCTCGGGAAGAGTCTCCACGGGCTGTATGGG
GACAACGTAGAGGAGATGGACTGGATGGTAGGACGGATCCTTGACACTTTGGACGTGGAG
GGTTTGAGCAACAGCACCCTCATTTATTTTACGTCGGATCACGGCGGTTCCCTAGAGAAT
CAACTTGGAAACACCCAGTATGGTGGCTGGAATGGAATTTATAAAGGTGGGAAGGGCATG
GGAGGATGGGAAGGTGGGATCCGCGTGCCCGGGATCTTCCGCTGGCCCGGGGTGCTCCCG
GCCGGCCGAGTGATTGGCGAGCCCACGAGTCTGATGGACGTGTTCCCCACCGTGGTCCGG
CTGGCGGGCGGCGAGGTGCCCCAGGACAGAGTGATTGACGGCCAAGACCTTCTGCCCTTG
CTCCTGGGGACAGCCCAACACTCAGACCACGAGTTCCTGATGCATTATTGTGAGAGGTTT
CTGCACGCAGCCAGGTGGCATCAACGGGACAGAGGAACAATGTGGAAAGTCCACTTTGTG
ACGCCTGTGTTCCAGCCAGAGGGAGCCGGTGCCTGCTATGGAAGAAAGGTCTGCCCGTGC
TTTGGGGAAAAAGTAGTCCACCACGATCCACCTTTGCTCTTTGACCTCTCAAGAGACCCT
TCTGAGACCCACATCCTCACACCAGCCTCAGAGCCCGTGTTCTATCAGGTGATGGAACGA
GTCCAGCAGGCGGTGTGGGAACACCAGCGGACACTCAGCCCAGTTCCTCTGCAGCTGGAC
AGGCTGGGCAACATCTGGAGACCGTGGCTGCAGCCCTGCTGTGGCCCGTTCCCCCTCTGC
TGGTGCCTTAGGGAAGATGACCCACAATAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X83573

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_1_Locus:
Xp22.3

# Metabolic_Enzyme_1_SNPs:
rs34412194; rs35143646; rs11222; rs17325750; rs11055; rs35718384; rs1875647; rs176994; rs12687057; rs211644; rs211640; rs190023; rs211646; rs211639; rs11798027; rs1972528; rs1985082; rs2302079; rs4892825; rs211641; rs6641673; rs4892828; rs211636; rs4892827; rs11797823; rs12847525; rs211642; rs169828; rs4892826; rs211638; rs211645; rs5982928; rs4892910; rs12392879; rs12690163; rs4892909; rs211637; rs5982944; rs5982926; rs5982947; rs5982948; rs41310272; rs28935474; rs5982618; rs41308353; rs2302078; rs35274634; rs34795651; rs11386125; rs35172906; rs5982943; rs35727588; rs5982621; rs35930766; rs5982942; rs5982620; rs5982619; rs5982941; rs12862274; rs34368774; rs12014203; rs5982937; rs12842633; rs35373572; rs1985083; rs35557443; rs12841888; rs7055850; rs12852998; rs6642073; rs34095951; rs28695378; rs11439303; rs6641671; rs7877827; rs191925; rs12845799; rs5982940; rs6642075; rs5982929; rs5982933; rs12841639; rs12690083; rs5982930; rs2238847; rs6642074; rs5982932; rs12853008; rs12847404; rs211643; rs12836850; rs12853316; rs36060128; rs35703084; rs5982939; rs7881434; rs12841616; rs35328022; rs3216370; rs6642076; rs12853583; rs35961426; rs12394933; rs3753140; rs28520254; rs5982938; rs12842105; rs5982931; rs1972527; rs12847425; rs3753141; rs12845808; rs183318; rs12852742; rs34854714; rs35592318; rs12388707; rs41309659; rs28602557; rs6642071; rs28678263; rs5982945; rs28545096; rs34081519; rs5982946; rs5982927; rs11152554; rs12393627; rs12852717; rs2302077; rs3747393; rs3747394; rs3747395; rs3747396; rs3827454; rs5982955

# Metabolic_Enzyme_1_General_References:
7720070; 9497243; 9409863

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5557

# Metabolic_Enzyme_2_Name:
Arylsulfatase B precursor

# Metabolic_Enzyme_2_Synonyms:
ASB; N-acetylgalactosamine- 4-sulfatase; G4S

# Metabolic_Enzyme_2_Gene_Name:
ARSB

# Metabolic_Enzyme_2_Protein_Sequence:
>Arylsulfatase B precursor
MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV
GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS
CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER
CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS
VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD
NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL
ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP
EYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRD
PEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM

# Metabolic_Enzyme_2_Number_of_Residues:
533

# Metabolic_Enzyme_2_Molecular_Weight:
59688

# Metabolic_Enzyme_2_Theoretical_pI:
8.31

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  sulfuric ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Hydrolysis of the 4-sulfate groups of the N- acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate

# Metabolic_Enzyme_2_Pathway:
map00531  Glycosaminoglycan degradation

# Metabolic_Enzyme_2_Reaction:
Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00884:Sulfatase

# Metabolic_Enzyme_2_Signals:
1-36

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.1.6.12

# Metabolic_Enzyme_2_GenBank_ID_Protein:
179077

# Metabolic_Enzyme_2_SwissProt_ID:
ARSB_HUMAN (P15848)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ARSB

# Metabolic_Enzyme_2_Geneatlas_id:
ARSB

# Metabolic_Enzyme_2_hgnc_id:
HGNC:714

# Metabolic_Enzyme_2_PDB_ID:
1FSU

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_2_Gene_Sequence:
>1602 bp
ATGGGTCCGCGCGGCGCGGCGAGCTTGCCCCGAGGCCCCGGACCTCGGCGGCTGCTCCTC
CCCGTCGTCCTCCCGCTGCTGCTGCTGCTGTTGTTGGCGCCGCCGGGCTCGGGCGCCGGG
GCCAGCCGGCCGCCCCACCTGGTCTTCTTGCTGGCAGACGACCTAGGCTGGAACGACGTC
GGCTTCCACGGCTCCCGCATCCGCACGCCGCACCTGGACGCGCTGGCGGCCGGCGGGGTG
CTCCTGGACAACTACTACACGCAGCCGCTGTGCACGCCGTCGCGGAGCCAGCTGCTCACT
GGCCGCTACCAGATCCGTACAGGTTTACAGCACCAAATAATCTGGCCCTGTCAGCCCAGC
TGTGTTCCTCTGGATGAAAAACTCCTGCCCCAGCTCCTAAAAGAAGCAGGTTATACTACC
CATATGGTCGGAAAATGGCACCTGGGAATGTACCGGAAAGAATGCCTTCCAACCCGCCGA
GGATTTGATACCTACTTTGGATATCTCCTGGGTAGTGAAGATTATTATTCCCATGAACGC
TGTACATTAATTGACGCTCTGAATGTCACACGATGTGCTCTTGATTTTCGAGATGGCGAA
GAAGTTGCAACAGGATATAAAAATATGTATTCAACAAACATATTCACCAAAAGGGCTATA
GCCCTCATAACTAACCATCCACCAGAGAAGCCTCTGTTTCTCTACCTTGCTCTCCAGTCT
GTGCATGAGCCCCTTCAGGTCCCTGAGGAATACTTGAAGCCATATGACTTTATCCAAGAC
AAGAACAGGCATCACTATGCAGGAATGGTGTCCCTTATGGATGAAGCAGTAGGAAATGTC
ACTGCAGCTTTAAAAAGCAGTGGGCTCTGGAACAACACGGTGTTCATCTTTTCTACAGAT
AACGGAGGGCAGACTTTGGCAGGGGGTAATAACTGGCCCCTTCGAGGAAGAAAATGGAGC
CTGTGGGAAGGAGGCGTCCGAGGGGTGGGCTTTGTGGCAAGCCCCTTGCTGAAGCAGAAG
GGCGTGAAGAACCGGGAGCTCATCCACATCTCTGACTGGCTGCCAACACTCGTGAAGCTG
GCCAGGGGACACACCAATGGCACAAAGCCTCTGGATGGCTTCGACGTGTGGAAAACCATC
AGTGAAGGAAGCCCATCCCCCAGAATTGAGCTGCTGCATAATATTGACCCAAACTTCGTG
GACTCTTCACCGTGTCCCAGGAACAGCATGGCTCCAGCAAAGGATGACTCTTCTCTTCCA
GAATATTCAGCCTTTAACACATCTGTCCATGCTGCAATTAGACATGGAAATTGGAAACTC
CTCACGGGCTACCCAGGCTGTGGTTACTGGTTCCCTCCACCGTCTCAATACAATGTTTCT
GAGATACCCTCATCAGACCCACCAACCAAGACCCTCTGGCTCTTTGATATTGATCGGGAC
CCTGAAGAAAGACATGACCTGTCCAGAGAATATCCTCACATCGTCACAAAGCTCCTGTCC
CGCCTACAGTTCTACCATAAACACTCAGTCCCCGTGTACTTCCCTGCACAGGACCCCCGC
TGTGATCCCAAGGCCACTGGGGTGTGGGGCCCTTGGATGTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
J05225

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_2_Locus:
5p11-q13|5q11-q13

# Metabolic_Enzyme_2_SNPs:
rs17220759; rs25414; rs1065757; rs25413; rs35757003; rs16876029; rs7704939; rs754567; rs754566; rs3088247; rs11750774; rs2173012; rs163127; rs163126; rs3098701; rs337865; rs234687; rs97729; rs337827; rs378912; rs337887; rs163215; rs339027; rs163299; rs337883; rs337826; rs338465; rs449839; rs7737068; rs378944; rs337879; rs3098678; rs3797550; rs2052550; rs337895; rs2925727; rs10039384; rs11960862; rs337852; rs3857405; rs337847; rs10474569; rs6453415; rs4704531; rs3098683; rs421734; rs10078690; rs9293758; rs7702409; rs6870550; rs337888; rs3846677; rs6453421; rs337851; rs7731315; rs337845; rs234910; rs3098679; rs4703768; rs12522844; rs337884; rs6874580; rs12658000; rs6887109; rs672413; rs4704535; rs6897944; rs7708387; rs337836; rs6863277; rs337885; rs10462560; rs3114495; rs7732099; rs11740104; rs186818; rs337846; rs4704534; rs337867; rs6453423; rs163216; rs4704530; rs7713155; rs751508; rs11743362; rs6887407; rs338460; rs6871810; rs921945; rs7717470; rs918580; rs4704525; rs447998; rs376749; rs10474567; rs337849; rs339032; rs337843; rs3114494; rs4704533; rs426586; rs784586; rs3852190; rs168091; rs10053925; rs1402684; rs180047; rs337853; rs6453420; rs10805924; rs7722869; rs7727110; rs4421085; rs7721866; rs7736777; rs10052939; rs3114493; rs10452492; rs559088; rs11747224; rs337844; rs3114492; rs6859069; rs12655291; rs16876147; rs3098695; rs3846679; rs16876062; rs7709486; rs10942879; rs97728; rs337835; rs336520; rs17219410; rs337875; rs6865582; rs16876106; rs3869024; rs163214; rs163128; rs2020404; rs6890245; rs6871197; rs414063; rs16875951; rs16875919; rs180295; rs3098681; rs6870443; rs6891547; rs10942870; rs180049; rs339030; rs3869025; rs32962; rs12054837; rs7710725; rs338458; rs6895479; rs189269; rs11739303; rs430185; rs10058204; rs3857404; rs6453417; rs337832; rs10942880; rs11748603; rs11957735; rs3098698; rs12655738; rs4704542; rs6861970; rs4704532; rs337841; rs4521454; rs3910652; rs413209; rs6876288; rs11738153; rs339034; rs11953253; rs337863; rs730836; rs7712469; rs6893857; rs11740161; rs12186484; rs3797556; rs6896300; rs337862; rs337833; rs10454896; rs338457; rs16875913; rs6890675; rs337877; rs784587; rs3114500; rs10045962; rs10805923; rs653413; rs12109559; rs17220863; rs3869026; rs7704725; rs16875940; rs10058261; rs337859; rs10514108; rs10942881; rs163129; rs3797552; rs337864; rs10514114; rs11740160; rs6888024; rs16875961; rs10044989; rs2919650; rs516908; rs7701898; rs10454897; rs16876110; rs337829; rs6895995; rs3869022; rs7706434; rs7725928; rs337850; rs2052549; rs3822473; rs11742709; rs12186766; rs3797554; rs427501; rs12654847; rs7711802; rs17818103; rs11741352; rs337876; rs6894968; rs17221983; rs7719520; rs12153089; rs339036; rs234688; rs9687996; rs10942868; rs4704524; rs3098680; rs6883131; rs12659281; rs339029; rs6898549; rs485142; rs337857; rs10462562; rs7730428; rs337834; rs10040033; rs339031; rs2043985; rs7724023; rs193123; rs16876057; rs3906812; rs17819357; rs10454895; rs427984; rs13340404; rs6897347; rs9632425; rs17820610; rs10064655; rs11955485; rs6453419; rs6860821; rs3098686; rs10039336; rs337840; rs12187930; rs12656514; rs11746751; rs11742408; rs784589; rs16876111; rs10042060; rs7705217; rs337828; rs671947; rs11748914; rs4447961; rs4470743; rs6453416; rs16876146; rs337881; rs339035; rs17221292; rs3098700; rs4703764; rs10805921; rs4704537; rs3098699; rs3822575; rs10055350; rs16876043; rs6870085; rs337856; rs337891; rs2919651; rs10039309; rs337860; rs9885048; rs191416; rs1866841; rs10942867; rs13184327; rs337886; rs16875905; rs16876115; rs11743827; rs12109126; rs7731288; rs336521; rs7729335; rs10755301; rs337878; rs184614; rs163130; rs784581; rs595479; rs7731568; rs17819944; rs9763635; rs13179571; rs4704528; rs10040776; rs3114501; rs337866; rs4704526; rs918581; rs10942872; rs650304; rs182880; rs11741182; rs17819603; rs688180; rs10040460; rs12658420; rs1866842; rs11749494; rs3822576; rs10462563; rs572281; rs784585; rs16875944; rs16876155; rs484234; rs16876279; rs11956583; rs16876048; rs180296; rs12654412; rs16875947; rs6887828; rs1583875; rs6897315; rs2919649; rs2099786; rs4704541; rs7731086; rs12109527; rs17218427; rs13185621; rs13177084; rs594686; rs784584; rs10462564; rs35676576; rs1899248; rs11739567; rs3098697; rs12515765; rs4515284; rs16876047; rs380061; rs16876045; rs12522377; rs6869313; rs9686232; rs3733895; rs3098684; rs11742860; rs12108732; rs3098692; rs17817904; rs3822577; rs10805922; rs337842; rs17818235; rs10942882; rs336523; rs13172853; rs13152961; rs2043984; rs16876063; rs339033; rs11740887; rs9765665; rs381184; rs337858; rs12656053; rs338462; rs7713152; rs10942877; rs12108960; rs11746011; rs337893; rs7730261; rs12109507; rs16875952; rs11744095; rs11739786; rs6887812; rs12187361; rs11957876; rs12515760; rs12108766; rs10040315; rs10942869; rs17819273; rs339028; rs6896262; rs16876044; rs11956904; rs3114497; rs12519566; rs9763091; rs11746616; rs7705475; rs12519881; rs16876150; rs337882; rs10072794; rs12188734; rs3822574; rs337830; rs16875946; rs11958663; rs16875902; rs13172903; rs337890; rs16875918; rs13184587; rs3951714; rs10040592; rs3114498; rs12522878; rs921944; rs10942878; rs7705181; rs16875949; rs17819429; rs337892; rs3098682; rs13178105; rs25415; rs12187584; rs7714654; rs9763629; rs12188045; rs10474568; rs12522380; rs12658374; rs7732938; rs163125; rs163124; rs16875887; rs10035905; rs7701438; rs7705926; rs1610960; rs34555226; rs613384; rs35714924; rs34610517; rs35597782; rs3075605; rs11424557; rs34152768; rs1079397; rs35905702; rs35583050; rs13354324; rs34833402; rs34139618; rs10036464; rs35220263; rs34215850; rs12653482; rs36036266; rs35130512; rs1717569; rs6862341; rs34830838; rs337889; rs34834944; rs34302981; rs9687115; rs13174426; rs35534569; rs34064696; rs10044381; rs337870; rs35317295; rs9799972; rs13156857; rs688286; rs35371175; rs41380947; rs34208828; rs28376183; rs28880323; rs35365107; rs13356043; rs35320861; rs34239164; rs519616; rs34498684; rs34056138; rs337831; rs35128236; rs34740869; rs35008584; rs34764801; rs34879488; rs16875915; rs28469385; rs35036564; rs35466881; rs35603282; rs13186087; rs34854556; rs34707299; rs338459; rs35697969; rs10044323; rs7707781; rs11387576; rs34904434; rs36187313; rs4704527; rs337873; rs13156748; rs1583874; rs13178011; rs35847346; rs784582; rs13161164; rs35689064; rs11750390; rs10574411; rs35368627; rs35436989; rs34148796; rs34805908; rs3857402; rs34209322; rs36189781; rs35548234; rs35433236; rs35038707; rs34923760; rs36189850; rs34264126; rs7736871; rs35281545; rs5868942; rs35103058; rs34155346; rs36034813; rs34432678; rs36176060; rs35285216; rs35428296; rs36186839; rs34917607; rs4133641; rs7448396; rs35839419; rs34033767; rs2547907; rs4704523; rs13155848; rs28520051; rs35667232; rs7702582; rs34499731; rs573979; rs35701136; rs337869; rs34341146; rs35588382; rs34032086; rs34346174; rs34857061; rs10474571; rs3098694; rs35285752; rs34026363; rs11747782; rs34338496; rs3098687; rs12109560; rs7700275; rs35740556; rs35013980; rs3797551; rs10942871; rs34768794; rs10474003; rs550807; rs2547909; rs34687985; rs7727489; rs337894; rs3114499; rs337839; rs337861; rs4021352; rs36162527; rs10618582; rs10574410; rs35363304; rs35681509; rs3114491; rs9632424; rs35911170; rs13166469; rs3035252; rs11746064; rs36144584; rs13155460; rs34737292; rs13181496; rs34368935; rs34755254; rs3886615; rs13176597; rs28370903; rs35116666; rs7722223; rs1092386; rs16875916; rs35201819; rs35893550; rs638060; rs36027876; rs16876023; rs34309008; rs35089219; rs12656441; rs4703763; rs12187354; rs10697601; rs35332751; rs638073; rs10942876; rs2547906; rs16876000; rs34259925; rs33970298; rs36191751; rs10594012; rs813049; rs337855; rs12109658; rs34574941; rs35025964; rs189804; rs34888064; rs2919652; rs3898436; rs539740; rs10053510; rs34533204; rs7703105; rs7735667; rs337880; rs235041; rs35496004; rs11413324; rs28673689; rs35400790; rs34402312; rs28405288; rs2197000; rs34040242; rs11743312; rs336524; rs6862636; rs394636; rs3098693; rs547170; rs35834955; rs13181505; rs34503367; rs11394259; rs10636559; rs337872; rs34595444; rs4703767; rs34055862; rs10551103; rs28634712; rs11268991; rs3899213; rs34105402; rs35730374; rs34714631; rs180048; rs13155497; rs34990932; rs10053225; rs11954358; rs13177269; rs3839268; rs34445419; rs28635990; rs11355138; rs13176594; rs337837; rs36197411; rs13181497; rs13172645; rs1091882; rs1692205; rs10045716; rs34469310; rs7724106; rs35262260; rs11299499; rs34034331; rs2197002; rs7709470; rs163131; rs35846655; rs34571367; rs2363609; rs337854; rs34898219; rs13177451; rs364620; rs9799962; rs34450984; rs36230002; rs35559177; rs12234098; rs34037585; rs13173889; rs36062148; rs13176845; rs10590311; rs34205498; rs35872703; rs35439643; rs11394958; rs35261341; rs35462751; rs35654714; rs34127515; rs1841991; rs11959213; rs10042203; rs16875943; rs12188269; rs35319484; rs337871; rs784588; rs35631654; rs1020186; rs7711919; rs10713151; rs34955466; rs35241200; rs34046420; rs10474002; rs3898435; rs34632923; rs35516786; rs35783391; rs36182430; rs6873893; rs4703766; rs9800277; rs36099030; rs10462561; rs13190257; rs35605269; rs10060752; rs6867149; rs3098688; rs34768660; rs186836; rs34706909; rs34688578; rs4482882; rs7717318; rs479148; rs35661103; rs35665104; rs35093883; rs13188817; rs34991706; rs7733057; rs5868940; rs10715023; rs13159135; rs11355139; rs6898498; rs1717570; rs7704110; rs35800814; rs35393927; rs3839269; rs894063; rs36146674; rs337868; rs13154740; rs13162166; rs36181206; rs337838; rs35626755; rs235042; rs10713491; rs7706760; rs35397898; rs189258; rs35719104; rs4704540; rs34902218; rs12153761; rs28693862; rs10683109; rs10057066; rs33943364; rs3035249; rs35928774; rs3857403; rs640837; rs3846678; rs4703765; rs35005469; rs2197001; rs34960858; rs8180446; rs7718164; rs34743994; rs10942874; rs35271764; rs35140194; rs12233989; rs36112811; rs3098685; rs10718349; rs2582725; rs4579229; rs10551102; rs7710146; rs35321003; rs9686894; rs35782121; rs5868939; rs34757674; rs34686491; rs486880; rs336522; rs28710792; rs34249973; rs35403493; rs36177025; rs35632995; rs35367883; rs34679554; rs11959212; rs7703437; rs34624505; rs11339765; rs6863008; rs784583; rs28366694; rs337874; rs35743244; rs36172998; rs4623130; rs35365110; rs34562530; rs34239279; rs34607195; rs183509; rs4133640; rs11750483; rs3098689; rs13181535; rs35596391; rs10525745; rs16876144; rs34302396; rs7716141; rs3889702; rs12655680; rs34833921; rs5868941; rs11440743; rs28616200; rs35516119; rs13178897; rs12189199; rs9885047; rs34367819; rs35644734; rs35377010; rs34286642; rs2547908; rs34960514; rs2112908; rs7701762; rs500390; rs35791513; rs35715333; rs34899252; rs34802644; rs13159416; rs35765094; rs7721596; rs13183099; rs13179012; rs497520; rs34221362; rs6887176; rs11272168; rs11308364; rs34016781; rs10068924; rs10514156; rs10942866; rs11742892; rs11747027; rs152727; rs163132; rs163133; rs17218031; rs2020368; rs2029904; rs2132537; rs336525; rs336526; rs337848; rs402208; rs4704521; rs478651; rs663646; rs6863289; rs6863492; rs705415; rs7702025; rs9293761

# Metabolic_Enzyme_2_General_References:
2303452; 1968043; 7687847; 1930244; 1390929; 7628016; 9032078; 1718978; 1550123; 8116615; 8125475; 8541342; 8651289; 9582121; 10036316; 11802522

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5551

# Metabolic_Enzyme_3_Name:
Arylsulfatase D precursor

# Metabolic_Enzyme_3_Synonyms:
ASD

# Metabolic_Enzyme_3_Gene_Name:
ARSD

# Metabolic_Enzyme_3_Protein_Sequence:
>Arylsulfatase D precursor
MRSAARRGRAAPAARDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYG
NNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNA
GSGGLPENETTFARILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTL
TNDCDPGRPPEVDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLF
FISWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSL
LHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGH
LEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPT
VVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQKDSGSVWKV
HYTTPQFHPEERGLLTAEASAHAEWGGVTHHRPPLLFDLSRDPSEARPLTPDSEPLYHAV
IARVGAAVSEHRQTLSPVPQQFSMSNILWKPWLQPCCGHFPFCSCHEDGDGTP

# Metabolic_Enzyme_3_Number_of_Residues:
593

# Metabolic_Enzyme_3_Molecular_Weight:
65072

# Metabolic_Enzyme_3_Theoretical_pI:
7.10

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  sulfuric ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Not Available

# Metabolic_Enzyme_3_Pathway:
Not Available

# Metabolic_Enzyme_3_Reaction:
Not Available

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00884:Sulfatase

# Metabolic_Enzyme_3_Signals:
1-33

# Metabolic_Enzyme_3_Transmembrane_Regions:
206-225; 229-251; 292-314

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.1.6.1

# Metabolic_Enzyme_3_GenBank_ID_Protein:
791002

# Metabolic_Enzyme_3_SwissProt_ID:
ARSD_HUMAN (P51689)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ARSD

# Metabolic_Enzyme_3_Geneatlas_id:
ARSD

# Metabolic_Enzyme_3_hgnc_id:
HGNC:717

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Lysosome (Potential)

# Metabolic_Enzyme_3_Gene_Sequence:
>1782 bp
ATGCGATCCGCCGCGCGGAGGGGACGCGCCGCGCCCGCCGCCAGGGACTCTTTGCCGGTG
CTACTGTTTTTATGCTTGCTTCTGAAGACGTGTGAACCTAAAACTGCAAATGCCTTTAAA
CCAAATATCCTACTGATCATGGCGGATGATCTAGGCACTGGGGATCTCGGTTGCTACGGG
AACAATACACTGAGAACGCCGAATATTGACCAGCTTGCAGAGGAAGGTGTGAGGCTCACT
CAGCACCTGGCGGCCGCCCCGCTCTGCACCCCAAGCCGAGCTGCATTCCTCACAGGGAGA
CATTCCTTCAGATCAGGCATGGACGCCAGCAATGGATACCGGGCCCTTCAGTGGAACGCA
GGCTCAGGTGGACTCCCTGAGAACGAAACCACTTTTGCAAGAATCTTGCAGCAGCATGGC
TATGCAACCGGCCTCATAGGAAAATGGCACCAGGGTGTGAATTGTGCATCCCGCGGGGAT
CACTGCCACCACCCCCTGAACCACGGATTTGACTATTTCTACGGCATGCCCTTCACGCTC
ACAAACGACTGTGACCCAGGCAGGCCCCCCGAAGTGGACGCCGCCCTGAGGGCGCAGCTC
TGGGGTTACACCCAGTTCCTGGCGCTGGGGATTCTCACCCTGGCTGCCGGCCAGACCTGC
GGTTTCTTCTCTGTCTCCGCGAGAGCAGTCACCGGCATGGCCGGCGTGGGCTGCCTGTTT
TTCATCTCTTGGTACTCCTCCTTCGGGTTTGTGCGACGCTGGAACTGTATCCTGATGAGA
AACCATGACGTCACGGAGCAACCCATGGTTCTGGAGAAAACAGCGAGTCTTATGCTAAAG
GAAGCTGTTTCCTATATTGAAAGACACAAGCATGGGCCATTTCTCCTCTTCCTTTCTTTG
CTGCATGTGCACATTCCCCTTGTGACCACGAGTGCATTCCTGGGGAAAAGTCAGCATGGC
TTATATGGTGATAATGTGGAGGAGATGGACTGGCTCATAGGTAAGGTTCTTAATGCCATC
GAAGACAATGGTTTAAAGAACTCAACATTCACGTATTTCACCTCTGACCATGGAGGACAT
TTAGAGGCAAGAGATGGACACAGCCAGTTAGGGGGATGGAACGGAATTTACAAAGGTGGG
AAGGGCATGGGAGGATGGGAAGGTGGGATCCGAGTGCCCGGGATCTTCCACTGGCCGGGG
GTGCTCCCGGCCGGCCGAGTGATTGGAGAGCCCACGAGCCTGATGGACGTGTTCCCTACT
GTGGTCCAGCTGGTGGGTGGCGAGGTGCCCCAGGACAGGGTGATTGATGGCCACAGCCTG
GTACCCTTGCTGCAGGGAGCTGAGGCACGCTCGGCACATGAGTTCCTGTTTCATTACTGT
GGGCAGCATCTTCACGCAGCACGCTGGCACCAGAAGGACAGTGGAAGCGTCTGGAAGGTT
CATTACACGACCCCGCAGTTCCACCCCGAGGAGCGGGGCCTGCTAACGGCCGAGGCGTCT
GCCCATGCTGAATGGGGAGGCGTGACCCATCACAGACCCCCTTTGCTCTTTGACCTCTCC
AGGGACCCCTCCGAGGCACGGCCCCTGACCCCCGACTCCGAGCCCCTGTACCACGCCGTG
ATAGCAAGGGTAGGTGCCGCGGTGTCGGAGCATCGGCAGACCCTGAGTCCTGTGCCCCAG
CAGTTTTCCATGAGCAACATCCTGTGGAAGCCGTGGCTGCAGCCGTGCTGCGGACATTTC
CCGTTCTGTTCATGCCACGAGGATGGGGATGGCACCCCCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X83572

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_3_Locus:
Xp22.3

# Metabolic_Enzyme_3_SNPs:
rs211653; rs211648; rs2228431; rs34494682; rs2229557; rs2228433; rs35096299; rs2302076; rs9334; rs211647; rs5939146; rs5939392; rs12388793; rs7884079; rs1043269; rs1043270; rs17331014; rs1043272; rs211649; rs12846104; rs5982920; rs6642066; rs4892908; rs2302077; rs5939397; rs1637781; rs1637779; rs1637777; rs12013334; rs4892907; rs6642067; rs1637776; rs3747394; rs5939398; rs3747393; rs1124546; rs5939399; rs5982919; rs5982617; rs211651; rs5939400; rs3747395; rs5982616; rs3827454; rs5982916; rs6567682; rs5982609; rs5982610; rs3747397; rs5982611; rs4141210; rs17335121; rs4141211; rs41302629; rs41311465; rs41302625; rs5939391; rs11538097; rs1138618; rs11556962; rs5982917; rs34210921; rs1138619; rs10634744; rs3078565; rs3747396; rs10218035; rs11556963; rs5982922; rs35837588; rs10555820; rs34910956; rs41308439; rs5982615; rs5939395; rs7053429; rs7065372; rs5982921; rs169829; rs11403125; rs34925283; rs5939147; rs10555819; rs12836012; rs35033726; rs1847214; rs211650; rs5939396; rs5982614; rs1698812; rs28587311; rs41297279; rs10624089; rs6642068; rs1637774; rs1627688; rs188430; rs34494989; rs5939148; rs7357997; rs211652; rs5982613; rs1502873; rs41302607; rs5939393; rs5982923; rs186112; rs5982918; rs4451470; rs1637780; rs1637778; rs10624690; rs34368255; rs5939401; rs1698814; rs41310266; rs35787994; rs5982914; rs7884701; rs35372805; rs7889616; rs3833415; rs7884791; rs7053284; rs5982915; rs11152554; rs12852742; rs5982606; rs5982911

# Metabolic_Enzyme_3_General_References:
7720070; 11177574

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5554

# Metabolic_Enzyme_4_Name:
Galactosylceramide sulfotransferase

# Metabolic_Enzyme_4_Synonyms:
GalCer sulfotransferase; Cerebroside sulfotransferase; 3'- phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase; 3'- phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase

# Metabolic_Enzyme_4_Gene_Name:
GAL3ST1

# Metabolic_Enzyme_4_Protein_Sequence:
>Galactosylceramide sulfotransferase
MLPPQKKPWESMAKGLVLGALFTSFLLLVYSYAVPPLHAGLASTTPEAAASCSPPALEPE
AVIRANGSAGECQPRRNIVFLKTHKTASSTLLNILFRFGQKHRLKFAFPNGRNDFDYPTF
FARSLVQDYRPGACFNIICNHMRFHYDEVRGLVPTNAIFITVLRDPARLFESSFHYFGPV
VPLTWKLSAGDKLTEFLQDPDRYYDPNGFNAHYLRNLLFFDLGYDNSLDPSSPQVQEHIL
EVERRFHLVLLQEYFDESLVLLKDLLCWELEDVLYFKLNARRDSPVPRLSGELYGRATAW
NMLDSHLYRHFNASFWRKVEAFGRERMAREVAALRHANERMRTICIDGGHAVDAAAIQDE
AMQPWQPLGTKSILGYNLKKSIGQRHAQLCRRMLTPEIQYLMDLGANLWVTKLWKFIRDF
LRW

# Metabolic_Enzyme_4_Number_of_Residues:
423

# Metabolic_Enzyme_4_Molecular_Weight:
48765

# Metabolic_Enzyme_4_Theoretical_pI:
8.78

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
Function:  galactose 3-O-sulfotransferase activity
Function:  galactosylceramide sulfotransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  Golgi apparatus

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the nonreducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro)

# Metabolic_Enzyme_4_Pathway:
map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_4_Reaction:
3'-phosphoadenylyl sulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + galactosylceramidesulfate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF06990:Gal-3-0_sulfotr

# Metabolic_Enzyme_4_Signals:
1-33

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.8.2.11

# Metabolic_Enzyme_4_GenBank_ID_Protein:
1871141

# Metabolic_Enzyme_4_SwissProt_ID:
G3ST1_HUMAN (Q99999)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
GAL3ST1

# Metabolic_Enzyme_4_Geneatlas_id:
GAL3ST1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:24240

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_4_Gene_Sequence:
>1272 bp
ATGCTGCCACCGCAGAAGAAGCCCTGGGAGTCCATGGCTAAGGGGCTGGTGCTGGGCGCG
CTCTTCACTAGTTTCCTGCTGCTGGTGTACTCCTATGCCGTGCCCCCGCTGCATGCCGGC
CTGGCCTCCACGACCCCGGAGGCCGCAGCGTCCTGCTCTCCACCTGCACTCGAGCCAGAG
GCAGTGATCCGGGCCAACGGCTCGGCGGGGGAGTGCCAGCCGCGGCGCAACATCGTGTTC
TTGAAGACGCACAAGACGGCCAGCAGCACCCTGCTCAACATCCTGTTCCGCTTCGGCCAG
AAGCACCGGCTCAAGTTCGCCTTCCCTAACGGCCGCAATGACTTCGACTACCCGACCTTC
TTCGCCCGCAGCCTGGTGCAGGACTATCGGCCCGGGGCCTGCTTCAACATCATCTGCAAC
CACATGCGCTTCCACTACGACGAGGTGCGCGGCCTGGTGCCGACCAACGCCATCTTCATC
ACGGTGCTCCGCGACCCCGCCCGCTTGTTCGAGTCCTCCTTCCACTACTTCGGGCCGGTG
GTGCCCCTCACGTGGAAGCTCTCGGCCGGCGACAAGCTGACCGAGTTCCTGCAAGACCCG
GATCGCTACTACGACCCCAACGGCTTCAATGCCCACTACCTCCGAAACCTGCTCTTCTTC
GACCTGGGCTATGACAACAGCCTGGACCCCAGCAGCCCGCAGGTGCAGGAGCACATCCTG
GAGGTGGAGCGTCGCTTCCACCTGGTGCTCCTTCAAGAGTACTTCGACGAGTCGCTGGTG
CTGCTGAAGGACCTGCTGTGCTGGGAGCTGGAGGACGTGCTCTACTTCAAGCTCAACGCC
CGCCGCGACTCGCCCGTGCCGCGGCTCTCGGGGGAGCTGTATGGGCGCGCCACCGCCTGG
AACATGCTGGACTCCCACCTCTACCGCCACTTCAACGCCAGCTTCTGGCGCAAGGTGGAG
GCCTTCGGGCGGGAGCGCATGGCCCGCGAGGTGGCCGCCCTGCGCCATGCCAACGAGCGC
ATGCGGACCATCTGCATCGACGGGGGCCACGCCGTGGACGCCGCCGCCATCCAGGACGAG
GCCATGCAGCCCTGGCAGCCGCTGGGCACCAAGTCCATCCTGGGCTACAACCTCAAGAAG
AGCATCGGGCAGCGGCACGCGCAGCTCTGCCGGCGCATGCTCACGCCCGAGATCCAGTAC
CTGATGGACCTCGGCGCCAACCTGTGGGTCACCAAGCTCTGGAAGTTCATTCGCGATTTC
CTGCGGTGGTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
D88667

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_4_Locus:
22q12.2

# Metabolic_Enzyme_4_SNPs:
rs2267161; rs5994320; rs4149488; rs4149490; rs12627772; rs42931; rs5994319; rs11912600; rs42929; rs16988782; rs5994321; rs42930; rs5749128; rs4149491; rs42928; rs2267159; rs42934; rs8142452; rs42932; rs42935; rs6518702; rs4820867; rs11704774; rs42933; rs2267158; rs4149486; rs4149493; rs42927; rs12628608; rs35336481; rs5749126; rs1015468; rs7286285; rs35997653; rs35424902; rs2528451; rs7287502; rs35703060; rs4149487; rs2528453; rs9606753; rs11307372; rs35696153; rs28700236; rs4149489; rs2412992; rs34728518; rs5844912; rs1015467; rs5844911; rs12159375; rs35211752; rs2528461; rs28838736; rs2528462; rs35908001; rs2528452; rs9606754; rs10711898; rs28636681; rs42926; rs34136895; rs9608988; rs2267160; rs12172153; rs11705676; rs9606752; rs35589021; rs1011897; rs35029608; rs2859472; rs35533918; rs5997684; rs13057430; rs9608981; rs35670229; rs35962480; rs16988790; rs2517987; rs2517991; rs2517993; rs2528454; rs2528457; rs2528458; rs2528459; rs2528460; rs42938; rs42939; rs5749124; rs5997681; rs956257; rs9621019

# Metabolic_Enzyme_4_General_References:
9030544; 10785389; 8830034

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5556

# Metabolic_Enzyme_5_Name:
Arylsulfatase A precursor

# Metabolic_Enzyme_5_Synonyms:
ASA; Cerebroside-sulfatase[Contains: Arylsulfatase A component B; Arylsulfatase A component C]

# Metabolic_Enzyme_5_Gene_Name:
ARSA

# Metabolic_Enzyme_5_Protein_Sequence:
>Arylsulfatase A precursor
MGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT
DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM
AGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP
LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE
RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRC
GKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSP
LLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSL
TAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARG
EDPALQICCHPGCTPRPACCHCPDPHA

# Metabolic_Enzyme_5_Number_of_Residues:
507

# Metabolic_Enzyme_5_Molecular_Weight:
53589

# Metabolic_Enzyme_5_Theoretical_pI:
6.01

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  sulfuric ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Hydrolyzes cerebroside sulfate

# Metabolic_Enzyme_5_Pathway:
map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_5_Reaction:
A cerebroside 3-sulfate + H2O = a cerebroside + sulfate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00884:Sulfatase

# Metabolic_Enzyme_5_Signals:
1-18

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.1.6.8

# Metabolic_Enzyme_5_GenBank_ID_Protein:
28858

# Metabolic_Enzyme_5_SwissProt_ID:
ARSA_HUMAN (P15289)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ARSA

# Metabolic_Enzyme_5_Geneatlas_id:
ARSA

# Metabolic_Enzyme_5_hgnc_id:
HGNC:713

# Metabolic_Enzyme_5_PDB_ID:
1E2S

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_5_Gene_Sequence:
>1524 bp
ATGGGGGCACCGCGGTCCCTCCTCCTGGCCCTGGCTGCTGGCCTGGCCGTTGCCCGTCCG
CCCAACATCGTGCTGATCTTTGCCGACGACCTCGGCTATGGGGACCTGGGCTGCTATGGG
CACCCCAGCTCTACCACTCCCAACCTGGACCAGCTGGCGGCGGGAGGGCTGCGGTTCACA
GACTTCTACGTGCCTGTGTCTCTGTGCACACCCTCTAGGGCCGCCCTCCTGACCGGCCGG
CTCCCGGTTCGGATGGGCATGTACCCTGGCGTCCTGGTGCCCAGCTCCCGGGGGGGCCTG
CCCCTGGAGGAGGTGACCGTGGCCGAAGTCCTGGCTGCCCGAGGCTACCTCACAGGAATG
GCCGGCAAGTGGCACCTTGGGGTGGGGCCTGAGGGGGCCTTCCTGCCCCCCCATCAGGGC
TTCCATCGATTTCTAGGCATCCCGTACTCCCACGACCAGGGCCCCTGCCAGAACCTGACC
TGCTTCCCGCCGGCCACTCCTTGCGACGGTGGCTGTGACCAGGGCCTGGTCCCCATCCCA
CTGTTGGCCAACCTGTCCGTGGAGGCGCAGCCCCCCTGGCTGCCCGGACTAGAGGCCCGC
TACATGGCTTTCGCCCATGACCTCATGGCCGACGCCCAGCGCCAGGATCGCCCCTTCTTC
CTGTACTATGCCTCTCACCACACCCACTACCCTCAGTTCAGTGGGCAGAGCTTTGCAGAG
CGTTCAGGCCGCGGGCCATTTGGGGACTCCCTGATGGAGCTGGATGCAGCTGTGGGGACC
CTGATGACAGCCATAGGGGACCTGGGGCTGCTTGAAGAGACGCTGGTCATCTTCACTGCA
GACAATGGACCTGAGACCATGCGTATGTCCCGAGGCGGCTGCTCCGGTCTCTTGCGGTGT
GGAAAGGGAACGACCTACGAGGGCGGTGTCCGAGAGCCTGCCTTGGCCTTCTGGCCAGGT
CATATCGCTCCCGGCGTGACCCACGAGCTGGCCAGCTCCCTGGACCTGCTGCCTACCCTG
GCAGCCCTGGCTGGGGCCCCACTGCCCAATGTCACCTTGGATGGCTTTGACCTCAGCCCC
CTGCTGCTGGGCACAGGCAAGAGCCCTCGGCAGTCTCTCTTCTTCTACCCGTCCTACCCA
GACGAGGTCCGTGGGGTTTTTGCTGTGCGGACTGGAAAGTACAAGGCTCACTTCTTCACC
CAGGGCTCTGCCCACAGTGATACCACTGCAGACCCTGCCTGCCACGCCTCCAGCTCTCTG
ACTGCTCATGAGCCCCCGCTGCTCTATGACCTGTCCAAGGACCCTGGTGAGAACTACAAC
CTGCTGGGGGGTGTGGCCGGGGCCACCCCAGAGGTGCTGCAAGCCCTGAAACAGCTTCAG
CTGCTCAAGGCCCAGTTAGACGCAGCTGTGACCTTCGGCCCCAGCCAGGTGGCCCGGGGC
GAGGACCCCGCCCTGCAGATCTGCTGTCATCCTGGCTGCACCCCCCGCCCAGCTTGCTGC
CATTGCCCAGATCCCCATGCCTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X52151

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_5_Locus:
22q13.31-qter|22q13.33

# Metabolic_Enzyme_5_SNPs:
rs2071421; rs743616; rs6151415; rs6151427; rs6151428; rs6151425; rs6151412; rs6151410; rs6151408; rs6151429; rs6151406; rs873697; rs6151424; rs6151419; rs6151423; rs6151420; rs762672; rs1106788; rs762673; rs6151421; rs6151413; rs6151418; rs6151416; rs5741862; rs131713; rs7288338; rs5770953; rs762668; rs6520160; rs6520159; rs131714; rs6520161; rs7288050; rs8142033; rs131715; rs6151403; rs6151405; rs5770805; rs28940894; rs28940893; rs6151422; rs28940895; rs6151411; rs34457249; rs1051539; rs6151407; rs34636260; rs6151426; rs5030763; rs6151414; rs6151409; rs9616801; rs6151417; rs2879913; rs8139846; rs8138770; rs35519140; rs7290199; rs35894766; rs34290947; rs34367180; rs6010033; rs4040040; rs35005618; rs13054262; rs34233484; rs131717; rs34969940; rs131716; rs2879912; rs2341003; rs3043715; rs8137818; rs34890441; rs8142531; rs6010032; rs6009939; rs34043300; rs2341004; rs34618802; rs36019124; rs6151404; rs11704557; rs131710; rs131718; rs131724; rs131728; rs3091400; rs5770963; rs762674; rs8137781; rs9616802

# Metabolic_Enzyme_5_General_References:
2562955; 1975241; 10591208; 1352993; 7628016; 9521684; 11124905; 7866401; 1353340; 1678251; 1673291; 1670590; 7902317; 7860068; 8101083; 8104633; 8101038; 2574462; 8095918; 7906588; 7581401; 8723680; 9090526; 9490297; 9600244; 9452102; 9744473; 9888390; 10220151

# Metabolic_Enzyme_5_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7533

# Macromolecular_Interacting_Partner_1_Name:
Coagulation factor XII precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Hageman factor; HAF[Contains: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Beta-factor XIIa part 2; Coagulation factor XIIa light chain]

# Macromolecular_Interacting_Partner_1_Gene_Name:
F12

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Coagulation factor XII precursor
MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHK
CTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCL
CPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRT
NPCLHGGRCLEVEGHRLCHCPVGYTGPFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQP
WASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQ
AAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCG
QRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAP
EDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSP
YVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGS
SILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYT
DVAYYLAWIREHTVS

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
615

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
67819

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.76

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. Alpha- factor XIIa activates factor XI to factor XIa

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00008:EGF;
PF00039:fn1;
PF00040:fn2;
PF00051:Kringle;
PF00089:Trypsin

# Macromolecular_Interacting_Partner_1_Signals:
1-19

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 3.4.21.38

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
180357

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
FA12_HUMAN (P00748)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
F12

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
F12

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:3530

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1848 bp
ATGAGGGCTCTGCTGCTCCTGGGGTTCCTGCTGGTGAGCTTGGAGTCAACACTTTCGATT
CCACCTTGGGAAGCCCCCAAGGAGCATAAGTACAAAGCTGAAGAGCACACAGTCGTTCTC
ACTGTCACCGGGGAGCCCTGCCACTTCCCCTTCCAGTACCACCGGCAGCTGTACCACAAA
TGTACCCACAAGGGCCGGCCAGGCCCTCAGCCCTGGTGTGCTACCACCCCCAACTTTGAT
CAGGACCAGCGATGGGGATACTGTTTGGAGCCCAAGAAAGTGAAAGACCACTGCAGCAAA
CACAGCCCCTGCCAGAAAGGAGGGACCTGTGTGAACATGCCAAGCGGCCCCCACTGTCTC
TGTCCACAACACCTCACTGGAAACCACTGCCAGAAAGAGAAGTGCTTTGAGCCTCAGCTT
CTCCGGTTTTTCCACAAGAATGAGATATGGTATAGAACTGAGCAAGCAGCTGTGGCCAGA
TGCCAGTGCAAGGGTCCTGATGCCCACTGCCAGCGGCTGGCCAGCCAGGCCTGCCGCACC
AACCCGTGCCTCCATGGGGGTCGCTGCCTAGAGGTGGAGGGCCACCGCCTGTGCCACTGC
CCGGTGGGCTACACCGGACCCTTCTGCGACGTGGACACCAAGGCAAGCTGCTATGATGGC
CGCGGGCTCAGCTACCGCGGCCTGGCCAGGACCACGCTCTCGGGTGCGCCCTGTCAGCCG
TGGGCCTCGGAGGCCACCTACCGGAACGTGACTGCCGAGCAAGCGCGGAACTGGGGACTG
GGCGGCCACGCCTTCTGCCGGAACCCGGACAACGACATCCGCCCGTGGTGCTTCGTGCTG
AACCGCGACCGGCTGAGCTGGGAGTACTGCGACCTGGCACAGTGCCAGACCCCAACCCAG
GCGGCGCCTCCGACCCCGGTGTCCCCTAGGCTTCATGTCCCACTCATGCCCGCGCAGCCG
GCACCGCCGAAGCCTCAGCCCACGACCCGGACCCCGCCTCAGTCCCAGACCCCGGGAGCC
TTGCCGGCGAAGCGGGAGCAGCCGCCTTCCCTGACCAGGAACGGCCCACTGAGCTGCGGG
CAGCGGCTCCGCAAGAGTCTGTCTTCGATGACCCGCGTCGTTGGCGGGCTGGTGGCGCTA
CGCGGGGCGCACCCCTACATCGCCGCGCTGTACTGGGGCCACAGTTTCTGCGCCGGCAGC
CTCATCGCCCCCTGCTGGGTGCTGACGGCCGCTCACTGCCTGCAGGACCGGCCCGCACCC
GAGGATCTGACGGTGGTGCTCGGCCAGGAACGCCGTAACCACAGCTGTGAGCCGTGCCAG
ACGTTGGCCGTGCGCTCCTACCGCTTGCACGAGGCCTTCTCGCCCGTCAGCTACCAGCAC
GACCTGGCTCTGTTGCGCCTTCAGGAGGATGCGGACGGCAGCTGCGCGCTCCTGTCGCCT
TACGTTCAGCCGGTGTGCCTGCCAAGCGGCGCCGCGCGACCCTCCGAGACCACGCTCTGC
CAGGTGGCCGGCTGGGGCCACCAGTTCGAGGGGGCGGAGGAATATGCCAGCTTCCTGCAG
GAGGCGCAGGTACCGTTCCTCTCCCTGGAGCGCTGCTCAGCCCCGGACGTGCACGGATCC
TCCATCCTCCCCGGCATGCTCTGCGCAGGGTTCCTCGAGGGCGGCACCGATGCGTGCCAG
GGTGATTCCGGAGGCCCGCTGGTGTGTGAGGACCAAGCTGCAGAGCGCCGGCTCACCCTG
CAAGGCATCATCAGCTGGGGATCGGGCTGTGGTGACCGCAACAAGCCAGGCGTCTACACC
GATGTGGCCTACTACCTGGCCTGGATCCGGGAGCACACCGTTTCCTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M17466

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_1_Locus:
5q33-qter

# Macromolecular_Interacting_Partner_1_SNPs:
rs2230938; rs17876030; rs2230939; rs17876047; rs17876033; rs1801020; rs4976648; rs7709674; rs4976692; rs17876019; rs17876025; rs17876044; rs17876020; rs17876031; rs17876018; rs17876032; rs4314418; rs17876046; rs6556321; rs17876045; rs17876048; rs17876026; rs4976649; rs17876027; rs17876014; rs17876028; rs17876015; rs6556320; rs2252316; rs1363352; rs17876040; rs2731676; rs2252317; rs17875996; rs17876006; rs6420096; rs17875997; rs6420097; rs17876003; rs7381103; rs35515200; rs17876034; rs41309748; rs41309750; rs41309752; rs41309746; rs34232995; rs41309134; rs33943360; rs41309138; rs34662844; rs36095913; rs41309754; rs17876010; rs35398840; rs35966430; rs41309136; rs35850757; rs41309140; rs34321750; rs17876017; rs11741335; rs17876013; rs17876029; rs41309760; rs17876016; rs17876012; rs17876041; rs17876005; rs17876007; rs17876043; rs41309132; rs17876042; rs34097461; rs41309762; rs41309756; rs11750450; rs17876038; rs2070853; rs2545801; rs2731672; rs2731675; rs34044544; rs34225933; rs4074057; rs4076508; rs4976691; rs6862195; rs6869526; rs7379524; rs7447593

# Macromolecular_Interacting_Partner_1_General_References:
2888762; 3754331; 3877053; 3011063; 3886654; 6604055; 8528215; 1544894; 2510163; 8049433; 10361128

# Macromolecular_Interacting_Partner_1_References:
10052595; 15173196; 2861197; 3169363

# Macromolecular_Interacting_Partner_2_ID:
7542

# Macromolecular_Interacting_Partner_2_Name:
Kininogen-1 precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Alpha-2-thiol proteinase inhibitor[Contains: Kininogen-1 heavy chain; Bradykinin; Kallidin I; Lysyl-bradykinin; Kallidin II; Kininogen-1 light chain; Low molecular weight growth- promoting factor]

# Macromolecular_Interacting_Partner_2_Gene_Name:
KNG1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Kininogen1 precursor
MKLITILFLCSRLLLSLTQESQSEEIDCNDKDLFKAVDAALKKYNSQNQSNNQFVLYRIT
EATKTVGSDTFYSFKYEIKEGDCPVQSGKTWQDCEYKDAAKAATGECTATVGKRSSTKFS
VATQTCQITPAEGPVVTAQYDCLGCVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLN
EVKRAQRQVVAGLNFRITYSIVQTNCSKENFLFLTPDCKSLWNGDTGECTDNAYIDIQLR
IASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTNSPELEETLTHTITKLNAENNATFYFK
IDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETKKLGQSLDCNAEVYVVPW
EKKIYPTVNCQPLGMISLMKRPPGFSPFRSSRIGEIKEETTVSPPHTSMAPAQDEERDSG
KEQGHTRRHDWGHEKQRKHNLGHGHKHERDQGHGHQRGHGLGHGHEQQHGLGHGHKFKLD
DDLEHQGGHVLDHGHKHKHGHGHGKHKNKGKKNGKHNGWKTEHLASSSEDSTTPSAQTQE
KTEGPTPIPSLAKPGVTVTFSDFQDSDLIATMMPPISPAPIQSDDDWIPDIQIDPNGLSF
NPISDFPDTTSPKCPGRPWKSVSEINPTTQMKESYYFDLTDGLS

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
644

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
71958

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.80

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  protease inhibitor activity
Function:  endopeptidase inhibitor activity
Function:  cysteine protease inhibitor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_2_Specific_Function:
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects:(4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00031:Cystatin

# Macromolecular_Interacting_Partner_2_Signals:
1-18

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
177890

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
KNG1_HUMAN (P01042)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
KNG1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
KNG1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:6383

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein; extracellular space

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1284 bp
ATGAAACTAATTACCATCCTTTTCCTCTGCTCCAGGCTACTACTAAGTTTAACCCAGGAA
TCACAGTCCGAGGAAATTGACTGCAATGACAAGGATTTATTTAAAGCTGTGGATGCTGCT
CTGAAGAAATATAACAGTCAAAACCAAAGTAACAACCAGTTTGTATTGTACCGCATAACT
GAAGCCACTAAGACGGTTGGCTCTGACACGTTTTATTCCTTCAAGTACGAAATCAAGGAG
GGGGATTGTCCTGTTCAAAGTGGCAAAACCTGGCAGGACTGTGAGTACAAGGATGCTGCA
AAAGCAGCCACTGGAGAATGCACGGCAACCGTGGGGAAGAGGAGCAGTACGAAATTCTCC
GTGGCTACCCAGACCTGCCAGATTACTCCAGCCGAGGGCCCTGTGGTGACAGCCCAGTAC
GACTGCCTCGGCTGTGTGCATCCTATATCAACGCAGAGCCCAGACCTGGAGCCCATTCTG
AGACACGGCATTCAGTACTTTAACAACAACACTCAACATTCCTCCCTCTTCATGCTTAAT
GAAGTAAAACGGGCCCAAAGACAGGTGGTGGCTGGATTGAACTTTCGAATTACCTACTCA
ATTGTGCAAACGAATTGTTCCAAAGAGAATTTTCTGTTCTTAACTCCAGACTGCAAGTCC
CTTTGGAATGGTGATACCGGTGAATGTACAGATAATGCATACATCGATATTCAGCTACGA
ATTGCTTCCTTCTCACAGAACTGTGACATTTATCCAGGGAAGGATTTTGTACAACCACCT
ACCAAGATTTGCGTGGGCTGCCCCAGAGATATACCCACCAACAGCCCAGAGCTGGAGGAG
ACACTGACTCACACCATCACAAAGCTTAATGCAGAGAATAACGCAACTTTCTATTTCAAG
ATTGACAATGTGAAAAAAGCAAGAGTACAGGTGGTGGCTGGCAAGAAATATTTTATTGAC
TTCGTGGCCAGGGAAACCACATGTTCCAAGGAAAGTAATGAAGAGTTGACCGAAAGCTGT
GAGACCAAAAAACTTGGCCAAAGCCTAGATTGCAACGCTGAAGTTTATGTGGTACCCTGG
GAGAAAAAAATTTACCCTACTGTCAACTGTCAACCACTGGGAATGATCTCACTGATGAAA
AGGCCTCCAGGTTTTTCACCTTTCCGATCATCACGAATAGGGGAAATAAAAGAAGAAACA
ACTAGTCACCTAAGGTCCTGCGAGTACAAGGGTCGACCCCCAAAGGCAGGGGCAGAGCCA
GCATCTGAGAGGGAGGTCTCTTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
K02566

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_2_Locus:
3q27

# Macromolecular_Interacting_Partner_2_SNPs:
rs2304456; rs5030024; rs1656922; rs5030015; rs1469859; rs5029980; rs1050274; rs5030096; rs5029974; rs1656925; rs2378115; rs1648698; rs5030072; rs710448; rs266760; rs1648697; rs5030022; rs1624569; rs5030023; rs5030002; rs5029999; rs5029979; rs5030020; rs5030094; rs1648722; rs1656914; rs698078; rs1851665; rs5030057; rs5030039; rs5029988; rs5030032; rs1656912; rs5030045; rs5030095; rs1829886; rs1656918; rs5030103; rs1851664; rs5030087; rs5030018; rs5030063; rs1648715; rs5030089; rs5029991; rs4686798; rs1656921; rs5030107; rs5029985; rs5029990; rs1656942; rs1624230; rs1622922; rs5030053; rs5030106; rs1648700; rs5030052; rs5029986; rs822366; rs5030076; rs5030092; rs5030059; rs710449; rs5029992; rs5030011; rs5030069; rs5030043; rs5030028; rs710447; rs5030111; rs3190571; rs822363; rs2689197; rs5030004; rs1621816; rs5030083; rs710446; rs5030051; rs2651640; rs1648716; rs5029987; rs5030033; rs1656910; rs1403694; rs1648712; rs166479; rs7644084; rs1836860; rs5030081; rs5030113; rs5030084; rs1656917; rs822620; rs822624; rs2304451; rs5030068; rs822364; rs5030048; rs5030041; rs266724; rs5030090; rs5030108; rs5030074; rs2304452; rs5030037; rs5030026; rs5030001; rs5030082; rs5030049; rs3841557; rs1656909; rs5030042; rs1656926; rs5030079; rs5030035; rs1656911; rs1648711; rs2062632; rs822362; rs5030031; rs5030025; rs1656920; rs5030088; rs5030012; rs5030085; rs266725; rs5030075; rs5029981; rs3856930; rs1648714; rs5030102; rs5030017; rs5030064; rs5030066; rs5030065; rs5029976; rs5030003; rs4686439; rs5030029; rs5030046; rs5030038; rs5030009; rs5029997; rs4686799; rs2651641; rs1656908; rs5030061; rs5030014; rs5030115; rs5030086; rs1656919; rs1656916; rs5030016; rs5030060; rs5029982; rs5029989; rs5029996; rs5030047; rs5030093; rs5030058; rs5030070; rs5029993; rs1648699; rs5029977; rs5030067; rs1648713; rs2304455; rs5029998; rs5030091; rs266723; rs5030044; rs5030109; rs5030104; rs5030062; rs5030050; rs5030073; rs5029978; rs1656915; rs5030027; rs5030099; rs5029994; rs5030036; rs13317089; rs11917445; rs5030071; rs5030078; rs5030054; rs5030080; rs5030112; rs1523435; rs5029975; rs2304454; rs5029995; rs865880; rs5030101; rs5029983; rs5030105; rs5030056; rs5030034; rs5030019; rs5030008; rs266726; rs9869244; rs5030077; rs4686800; rs11929295; rs5030100; rs5030021; rs5030013; rs5030114; rs13084325; rs5030055; rs9882598; rs5030000; rs5030110; rs13098645; rs10440056; rs3774291; rs2651639; rs5029973; rs5029970; rs3806688; rs5029969; rs3774292; rs3821815; rs3806689; rs5029971; rs10439971; rs17838879; rs10440057; rs5029972; rs10439970; rs33934143; rs13072823; rs36121564; rs9866324; rs11328552; rs28461768; rs11276552; rs28607874; rs35578318; rs1212217; rs34098137; rs10571187; rs822365; rs35995617; rs10531727; rs11425592; rs11425593; rs35477316; rs35079146; rs34693243; rs13095338; rs1209472; rs34650598; rs13062473; rs28496811; rs13072436; rs35957661; rs10575985; rs13072694; rs34231414; rs9877452; rs10703695; rs10575988; rs10576660; rs34707597; rs34208952; rs35394339; rs11275829; rs11057; rs11328550; rs10662949; rs9818796; rs34957759; rs1656927; rs9825929; rs12635879; rs35569041; rs13063282; rs2912567; rs34651871; rs1211468; rs28390219; rs9819941; rs10575986; rs13095484; rs2304453; rs9851780; rs11328551; rs35025634; rs5030030; rs192371; rs13083619; rs35668151; rs35596301; rs13085884; rs13072546; rs9812764; rs11394050; rs3217421; rs13072563; rs35138120; rs34745532; rs13065593; rs10575987; rs35823469; rs34728507; rs35667207; rs10571591; rs35425194; rs2651642; rs35065127; rs3836479; rs10702686; rs11297934; rs1648717; rs36160200; rs10513803; rs10937264; rs10937265; rs10937266; rs11712801; rs11918289; rs11924390; rs11927941; rs12491806; rs12497377; rs12629364; rs13098570; rs13315296; rs1392952; rs1656939; rs1656940; rs1656966; rs1972703; rs2033122; rs266721; rs266722; rs266762; rs266763; rs266764; rs266767; rs34358682; rs35557208; rs35853604; rs4615069; rs4686436; rs5030097; rs5030098; rs6796803; rs6807774; rs7624355; rs7647509; rs822368; rs822370; rs822371; rs822373; rs905056; rs905057; rs961010; rs9817038; rs9838998; rs9852828

# Macromolecular_Interacting_Partner_2_General_References:
6441591; 2989293; 4054110; 4952632; 3484703; 3366244; 7589467; 2989294; 3182782; 12754519

# Macromolecular_Interacting_Partner_2_References:
3436959; 3928613

# Macromolecular_Interacting_Partner_3_ID:
7549

# Macromolecular_Interacting_Partner_3_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
INS

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_3_Signals:
1-24

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
INS

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11p15.5

# Macromolecular_Interacting_Partner_3_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_3_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_3_References:
10570222; 11445552; 12145165; 14707487

# Macromolecular_Interacting_Partner_4_ID:
7551

# Macromolecular_Interacting_Partner_4_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_4_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_4_Locus:
6p21.3

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_4_References:
12885578; 16143863; 1649796; 9119455

# Macromolecular_Interacting_Partner_5_ID:
7121

# Macromolecular_Interacting_Partner_5_Name:
Myelin basic protein

# Macromolecular_Interacting_Partner_5_Synonyms:
MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein

# Macromolecular_Interacting_Partner_5_Gene_Name:
MBP

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Myelin basic protein
MGNHAGKRELNAEKASTNSETNRGESEKKRNLGELSRTTSEDNEVFGEADANQNNGTSSQ
DTAVTDSKRTADPKNAWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTI
QEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFG
GDRGAPKRGSGKDSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKG
RGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSP
MARR

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
304

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
33117

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
10.46

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  structural molecule activity
Function:  structural constituent of myelin sheath
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF01669:Myelin_MBP

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
307159

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
MBP_HUMAN (P02686)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
MBP

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
MBP

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:6925

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Myelin membrane; peripheral membrane protein; cytoplasmic side. Note=Cytoplasmic side of myelin

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>483 bp
ATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGT
ACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGAC
TCCATCGGGCGCTTCTTTGGCGGTGACAGGGGTGCGCCCAAGCGGGGCTCTGGCAAGGAC
TCACACCACCCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGG
ACCCAAGATGAAAACCCCGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACACCA
CCCCCGTCGCAGGGAAAGGGGGCCGAAGGCCAGAGACCAGGATTTGGCTACGGAGGCAGA
GCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTT
TCCAAAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGC
TGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
M30047

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:18

# Macromolecular_Interacting_Partner_5_Locus:
18q23

# Macromolecular_Interacting_Partner_5_SNPs:
rs470797; rs12406; rs470279; rs470717; rs9199; rs470933; rs17026; rs470822; rs470181; rs4890796; rs2279080; rs1789087; rs7232502; rs9967506; rs1789079; rs1049004; rs470554; rs1617144; rs470724; rs470821; rs1629089; rs7244713; rs2279078; rs470823; rs470555; rs7229288; rs470826; rs7236968; rs6565924; rs470546; rs1789090; rs1667905; rs2279079; rs1048947; rs1789092; rs1048871; rs8083543; rs8083056; rs17060173; rs2282557; rs1375967; rs1632498; rs1789088; rs966080; rs12959006; rs1667920; rs470938; rs12970928; rs1617173; rs470550; rs8094950; rs1450190; rs11660113; rs12456940; rs1789082; rs470213; rs12605040; rs1667908; rs1789080; rs12606687; rs3752069; rs1632516; rs1630958; rs2282569; rs470180; rs9959403; rs11876362; rs4890897; rs1789081; rs12454672; rs11874174; rs1115014; rs1789091; rs1789093; rs12457502; rs10454721; rs2406727; rs1789086; rs731091; rs12454662; rs470871; rs9319657; rs1789089; rs731725; rs8089193; rs11664489; rs470241; rs470473; rs470250; rs470542; rs2051344; rs636692; rs470903; rs509620; rs470498; rs470970; rs470144; rs1789134; rs2282566; rs642506; rs647963; rs470131; rs470907; rs8094821; rs470934; rs470881; rs11150992; rs574099; rs7235695; rs1789085; rs558747; rs2000811; rs736421; rs8093926; rs470967; rs470559; rs1145361; rs3900176; rs2008323; rs8089096; rs470895; rs1622577; rs470866; rs4890791; rs7231830; rs8086634; rs8091710; rs7241461; rs2974260; rs8092433; rs507097; rs470293; rs11874114; rs3794846; rs9675994; rs2008547; rs470291; rs8094289; rs8090356; rs1789137; rs650801; rs2282574; rs6565927; rs523243; rs9964845; rs8090463; rs3794854; rs1789135; rs470318; rs9676140; rs2013963; rs1145360; rs470798; rs470578; rs898229; rs4890893; rs470276; rs584089; rs716458; rs966782; rs470793; rs11150994; rs1026520; rs470468; rs7233242; rs7241373; rs1026521; rs7234883; rs8095585; rs4890883; rs3752070; rs617024; rs3794830; rs470261; rs6565928; rs559418; rs470330; rs11662430; rs3794845; rs9954182; rs470681; rs11661533; rs9676181; rs3934445; rs2282575; rs7236892; rs1674716; rs475841; rs1539991; rs12955019; rs3934443; rs470340; rs11664952; rs475791; rs470508; rs3794835; rs12456480; rs17576751; rs11662391; rs9962038; rs3861306; rs470349; rs470549; rs1674724; rs3794848; rs4890890; rs1612497; rs4890873; rs2122450; rs470924; rs12456341; rs470480; rs470670; rs896038; rs12955250; rs1789083; rs12456475; rs8094060; rs470695; rs1674725; rs3794832; rs3829619; rs2597295; rs4890882; rs1667911; rs12604476; rs1667914; rs4890876; rs1145359; rs3829621; rs721287; rs12964484; rs7407368; rs10514234; rs470664; rs1246874; rs2597296; rs4890888; rs8088304; rs7232929; rs3934444; rs595997; rs8090467; rs3794842; rs4890875; rs3794836; rs9676113; rs11661755; rs2290824; rs12607027; rs8090438; rs7239582; rs1674715; rs898227; rs3794834; rs9959822; rs2974261; rs11661054; rs556751; rs10439001; rs4890891; rs555827; rs921336; rs11663697; rs1674719; rs8084674; rs1145362; rs2282571; rs12956305; rs3934446; rs948880; rs11876196; rs9958028; rs3829620; rs1246603; rs4890877; rs470929; rs3794829; rs510527; rs1026519; rs506323; rs470190; rs12967023; rs2597294; rs3752068; rs871673; rs11875151; rs7239141; rs12454790; rs559292; rs9964602; rs2974262; rs3794837; rs2060649; rs17660901; rs8090564; rs470769; rs4890788; rs9949587; rs17060237; rs17060249; rs2290825; rs11663770; rs17060251; rs9949636; rs8099667; rs3829623; rs7407423; rs9807514; rs470478; rs9949607; rs12608398; rs921337; rs3794851; rs10469072; rs2282573; rs13381497; rs4890786; rs11151001; rs11663325; rs3794843; rs11663742; rs8094626; rs8099008; rs11150998; rs1789131; rs12456024; rs7243285; rs2282572; rs2282570; rs12458393; rs1246872; rs470533; rs12607797; rs2974263; rs7233979; rs7233574; rs11663170; rs1246604; rs12968222; rs580635; rs6565925; rs629945; rs4890790; rs12959623; rs3794839; rs470577; rs1667918; rs11664872; rs9961315; rs7233524; rs7237128; rs12604625; rs11151000; rs12458282; rs8090465; rs8094402; rs11150997; rs10782015; rs8091801; rs1246873; rs8099782; rs8095130; rs8097284; rs1246602; rs1261920; rs1667916; rs8090930; rs470640; rs3829622; rs4890787; rs7231675; rs8090772; rs11876149; rs7234544; rs17060250; rs4890887; rs7232525; rs479114; rs1667910; rs7505230; rs8098769; rs470238; rs520047; rs8088143; rs7227084; rs570389; rs7242698; rs11662063; rs7232346; rs11659352; rs4890785; rs751361; rs12456333; rs17060192; rs470584; rs11151002; rs12959904; rs4890795; rs7228426; rs1268934; rs12967352; rs470479; rs3794840; rs7233072; rs470453; rs2156496; rs470186; rs3813079; rs9952064; rs12454943; rs17576996; rs8096433; rs470252; rs512343; rs10221416; rs7241533; rs1246605; rs13381108; rs7239250; rs470551; rs9945622; rs11660885; rs2290826; rs8097277; rs12958866; rs1246601; rs7237284; rs557659; rs685975; rs7238650; rs7231932; rs1789084; rs3794852; rs12960478; rs3794847; rs3794838; rs581552; rs11664836; rs12456380; rs559399; rs11660979; rs470212; rs12962017; rs7234903; rs10153418; rs4890878; rs470567; rs17060297; rs11150996; rs470335; rs470493; rs6565923; rs2276277; rs1789094; rs470319; rs4890901; rs9966986; rs2276276; rs10221343; rs1048688; rs11559012; rs34545130; rs34435038; rs36036469; rs1893710; rs11559009; rs35499437; rs2897506; rs13381530; rs2897504; rs35358094; rs5024153; rs33966437; rs5826495; rs11331748; rs1584579; rs35523743; rs34095806; rs1977969; rs36171082; rs10454722; rs35925062; rs34454490; rs12955050; rs35923807; rs34753010; rs36073460; rs12605430; rs34783785; rs34678081; rs12962477; rs35136851; rs35135189; rs11359542; rs11293166; rs2406725; rs9952768; rs5826496; rs10713423; rs34309442; rs6146398; rs4494640; rs1667906; rs34330273; rs34008680; rs4890899; rs2897505; rs2897507; rs35106585; rs34930920; rs12957636; rs12956652; rs1059474; rs7964; rs1625042; rs36172305; rs8093312; rs34246877; rs34308071; rs35453944; rs10682890; rs1667907; rs8088587; rs35240388; rs12956648; rs35692920; rs11370299; rs9964017; rs9966152; rs35560093; rs11876582; rs36078757; rs3838892; rs28593671; rs12604394; rs11331749; rs1789076; rs12958854; rs7234131; rs34142608; rs12958875; rs12326360; rs1625095; rs9959030; rs3056846; rs12962471; rs1375968; rs34716646; rs12607023; rs34660063; rs35914059; rs28471065; rs28474795; rs35537892; rs517525; rs8093194; rs34161355; rs4890898; rs12958314; rs35530947; rs11359541; rs36022168; rs508028; rs34698233; rs1622189; rs1789078; rs1667919; rs35957303; rs34863406; rs11338824; rs28384331; rs36230198; rs35043317; rs9944542; rs35066411; rs5826492; rs539926; rs7234396; rs3943395; rs34236204; rs34392069; rs35688328; rs28455004; rs3214873; rs12969118; rs36038482; rs2850209; rs34098362; rs35490623; rs34705439; rs2122449; rs35525905; rs12455658; rs36096666; rs12953724; rs11370657; rs35789059; rs35575050; rs4890889; rs35706956; rs504433; rs2923070; rs12954656; rs35721326; rs1269742; rs35437082; rs34825980; rs35768267; rs898228; rs5826488; rs35938490; rs9961421; rs34982848; rs33983406; rs34914518; rs1046930; rs12456666; rs5826494; rs35204432; rs35870819; rs12458733; rs12960582; rs34088194; rs7505207; rs2974264; rs538222; rs34447266; rs1789128; rs1667949; rs11660481; rs539929; rs12959308; rs12326491; rs4890880; rs34928057; rs470893; rs35090226; rs8083865; rs11298729; rs35905017; rs12970079; rs28523669; rs8090485; rs13381841; rs12970202; rs34179301; rs1667913; rs35778536; rs10613302; rs3056785; rs33971375; rs34325356; rs1269761; rs12454221; rs11367089; rs35417333; rs35687559; rs470921; rs11455414; rs28509179; rs9944893; rs8084038; rs3214874; rs692894; rs8083996; rs8086213; rs35726542; rs34908275; rs470443; rs11402968; rs28360810; rs36105123; rs1789122; rs1247188; rs34685116; rs35111199; rs7236625; rs11150999; rs28590173; rs12955289; rs28665744; rs1271961; rs28558631; rs486033; rs12961856; rs3838890; rs3897650; rs12327285; rs35033872; rs2923074; rs35122022; rs35400049; rs34142646; rs12327217; rs5826493; rs12969206; rs1789141; rs12970402; rs11432792; rs35510052; rs589012; rs12454195; rs10645727; rs36122723; rs5826490; rs34266248; rs12958275; rs12455703; rs4890789; rs34205845; rs2406710; rs35796733; rs2897498; rs28481404; rs28609066; rs12969724; rs35011710; rs28561083; rs12969037; rs35635526; rs11150993; rs10670800; rs12605476; rs12968671; rs11370656; rs3056784; rs11457639; rs2923072; rs34473421; rs10532700; rs34988017; rs28454850; rs35642343; rs3017501; rs11877231; rs3897649; rs34154093; rs28729533; rs28776780; rs34738737; rs12454163; rs11661965; rs35106465; rs9954479; rs35510843; rs28567439; rs34915667; rs35341754; rs10556310; rs35177629; rs1667912; rs527722; rs35582225; rs6650701; rs10567845; rs34397715; rs34462513; rs1055757; rs34768183; rs12959886; rs1789253; rs1674723; rs12456274; rs35417866; rs617969; rs606777; rs12965696; rs34070985; rs2850208; rs1789129; rs35520696; rs34965445; rs34555682; rs1667948; rs12957833; rs1261909; rs3794850; rs35493282; rs7231677; rs3056773; rs5021489; rs4527105; rs12953573; rs34723130; rs470367; rs35192115; rs36017394; rs12953638; rs7236014; rs34945822; rs10556309; rs470980; rs35099759; rs475324; rs583949; rs34544199; rs8091396; rs12454264; rs11422817; rs1674721; rs12956572; rs470917; rs28879124; rs28661612; rs28488290; rs12955776; rs11872487; rs11273645; rs1046931; rs34829403; rs519582; rs34530190; rs3794849; rs10654101; rs35854660; rs1667909; rs10554697; rs558450; rs35099294; rs12457312; rs28415261; rs35321171; rs12970404; rs34879896; rs33932270; rs12953723; rs12956404; rs1789142; rs9959483; rs12956948; rs9951345; rs35591984; rs8083864; rs10526394; rs3838891; rs35068332; rs598348; rs35884498; rs7232640; rs11436164; rs12607641; rs36047934; rs7228598; rs1789130; rs34529087; rs33929749; rs35071014; rs1789254; rs5826489; rs11663912; rs1247187; rs34473725; rs12953684; rs28815543; rs34568117; rs9319655; rs10644482; rs12955437; rs10656491; rs1674722; rs11363307; rs11321875; rs11397672; rs34630649; rs1667917; rs12953712; rs470685; rs35438841; rs36038543; rs10469088; rs1667915; rs35568206; rs35710301; rs4890879; rs2923073; rs28424014; rs11305404; rs33957999; rs34160746; rs7226491; rs9960721; rs7504502; rs35983546; rs35229872; rs12456295; rs7237258; rs1789136; rs664122; rs9957016; rs34623569; rs34009398; rs470505; rs12960504; rs13381797; rs7242091; rs645714; rs4890886; rs611551; rs563901; rs35173653; rs1789127; rs3842671; rs34387671; rs33913578; rs8085851; rs33974021; rs28549273; rs9952636; rs34430892; rs3056884; rs36069074; rs34518416; rs10163866; rs10667203; rs11446871; rs2897508; rs10577153; rs28760550; rs9954826; rs35190126; rs33940322; rs28555591; rs2406729; rs28497522; rs9965258; rs1044088; rs11875409; rs12326156; rs12455522; rs12966573; rs12967593; rs1617137; rs1667901; rs1667903; rs1667957; rs17060488; rs17060490; rs17061722; rs17587448; rs17841728; rs1789118; rs1789119; rs1789121; rs1789256; rs2013313; rs35305608; rs470615; rs470683; rs4890902; rs4890903; rs721286; rs7236465; rs8097016; rs896035; rs896036; rs896040; rs896041; rs948884; rs9944908; rs9955987; rs9958654; rs9961194; rs9966022

# Macromolecular_Interacting_Partner_5_General_References:
4108501; 2427738; 2425357; 2442403; 2472816; 7504278; 1689270; 2426402; 2466844; 7574672; 6201481; 4099924; 7685161; 5128665; 7544282; 9020143

# Macromolecular_Interacting_Partner_5_References:
1372178; 2421004; 2480186; 6165009

# Macromolecular_Interacting_Partner_6_ID:
7201

# Macromolecular_Interacting_Partner_6_Name:
von Willebrand factor precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
vWF[Contains: von Willebrand antigen 2; von Willebrand antigen II]

# Macromolecular_Interacting_Partner_6_Gene_Name:
VWF

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>von Willebrand factor precursor
MIPARFAGVLLALALILPGTLCAEGTRGRSSTARCSLFGSDFVNTFDGSMYSFAGYCSYL
LAGGCQKRSFSIIGDFQNGKRVSLSVYLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYL
ETEAGYYKLSGEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQEGTL
TSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQKGLWEQCQLLKSTSVFARCHPL
VDPEPFVALCEKTLCECAGGLECACPALLEYARTCAQEGMVLYGWTDHSACSPVCPAGME
YRQCVSPCARTCQSLHINEMCQERCVDGCSCPEGQLLDEGLCVESTECPCVHSGKRYPPG
TSLSRDCNTCICRNSQWICSNEECPGECLVTGQSHFKSFDNRYFTFSGICQYLLARDCQD
HSFSIVIETVQCADDRDAVCTRSVTVRLPGLHNSLVKLKHGAGVAMDGQDIQLPLLKGDL
RIQHTVTASVRLSYGEDLQMDWDGRGRLLVKLSPVYAGKTCGLCGNYNGNQGDDFLTPSG
LAEPRVEDFGNAWKLHGDCQDLQKQHSDPCALNPRMTRFSEEACAVLTSPTFEACHRAVS
PLPYLRNCRYDVCSCSDGRECLCGALASYAAACAGRGVRVAWREPGRCELNCPKGQVYLQ
CGTPCNLTCRSLSYPDEECNEACLEGCFCPPGLYMDERGDCVPKAQCPCYYDGEIFQPED
IFSDHHTMCYCEDGFMHCTMSGVPGSLLPDAVLSSPLSHRSKRSLSCRPPMVKLVCPADN
LRAEGLECTKTCQNYDLECMSMGCVSGCLCPPGMVRHENRCVALERCPCFHQGKEYAPGE
TVKIGCNTCVCRDRKWNCTDHVCDATCSTIGMAHYLTFDGLKYLFPGECQYVLVQDYCGS
NPGTFRILVGNKGCSHPSVKCKKRVTILVEGGEIELFDGEVNVKRPMKDETHFEVVESGR
YIILLLGKALSVVWDRHLSISVVLKQTYQEKVCGLCGNFDGIQNNDLTSSNLQVEEDPVD
FGNSWKVSSQCADTRKVPLDSSPATCHNNIMKQTMVDSSCRILTSDVFQDCNKLVDPEPY
LDVCIYDTCSCESIGDCACFCDTIAAYAHVCAQHGKVVTWRTATLCPQSCEERNLRENGY
ECEWRYNSCAPACQVTCQHPEPLACPVQCVEGCHAHCPPGKILDELLQTCVDPEDCPVCE
VAGRRFASGKKVTLNPSDPEHCQICHCDVVNLTCEACQEPGGLVVPPTDAPVSPTTLYVE
DISEPPLHDFYCSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVE
YHDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKIDRPEASRI
ALLLMASQEPQRMSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENKAFVL
SSVDELEQQRDEIVSYLCDLAPEAPPPTLPPHMAQVTVGPGLLGVSTLGPKRNSMVLDVA
FVLEGSDKIGEADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQSKGD
ILQRVREIRYQGGNRTNTGLALRYLSDHSFLVSQGDREQAPNLVYMVTGNPASDEIKRLP
GDIQVVPIGVGPNANVQELERIGWPNAPILIQDFETLPREAPDLVLQRCCSGEGLQIPTL
SPAPDCSQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPRLTQVSVLQYGSITT
IDVPWNVVPEKAHLLSLVDVMQREGGPSQIGDALGFAVRYLTSEMHGARPGASKAVVILV
TDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQLRILAGPAGDSNVVKLQRIEDLPTM
VTLGNSFLHKLCSGFVRICMDEDGNEKRPGDVWTLPDQCHTVTCQPDGQTLLKSHRVNCD
RGLRPSCPNSQSPVKVEETCGCRWTCPCVCTGSSTRHIVTFDGQNFKLTGSCSYVLFQNK
EQDLEVILHNGACSPGARQGCMKSIEVKHSALSVELHSDMEVTVNGRLVSVPYVGGNMEV
NVYGAIMHEVRFNHLGHIFTFTPQNNEFQLQLSPKTFASKTYGLCGICDENGANDFMLRD
GTVTTDWKTLVQEWTVQRPGQTCQPILEEQCLVPDSSHCQVLLLPLFAECHKVLAPATFY
AICQQDSCHQEQVCEVIASYAHLCRTNGVCVDWRTPDFCAMSCPPSLVYNHCEHGCPRHC
DGNVSSCGDHPSEGCFCPPDKVMLEGSCVPEEACTQCIGEDGVQHQFLEAWVPDHQPCQI
CTCLSGRKVNCTTQPCPTAKAPTCGLCEVARLRQNADQCCPEYECVCDPVSCDLPPVPHC
ERGLQPTLTNPGECRPNFTCACRKEECKRVSPPSCPPHRLPTLRKTQCCDEYECACNCVN
STVSCPLGYLASTATNDCGCTTTTCLPDKVCVHRSTIYPVGQFWEEGCDVCTCTDMEDAV
MGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQ
WASPENPCLINECVRVKEEVFIQQRNVSCPQLEVPVCPSGFQLSCKTSACCPSCRCERME
ACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENNTGEC
CGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHK
CLAEGGKIMKIPGTCCDTCEEPECNDITARLQYVKVGSCKSEVEVDIHYCQGKCASKAMY
SIDINDVQDQCSCCSPTRTEPMQVALHCTNGSVVYHEVLNAMECKCSPRKCSK

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
2813

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
309301

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
5.21

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  organismal physiological process
Process:  regulation of body fluids
Process:  hemostasis
Process:  blood coagulation
Process:  cellular process
Process:  cell adhesion
 ||
>>>
Component:  extracellular matrix
Component:  extracellular matrix (sensu Metazoa)

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF08742:DUF1787;
PF01826:TIL;
PF00092:VWA;
PF00093:VWC;
PF00094:VWD

# Macromolecular_Interacting_Partner_6_Signals:
1-22

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
37947

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
VWF_HUMAN (P04275)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
VWF

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
VWF

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:12726

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Secreted protein. Note=Localized to storage granules

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>8442 bp
ATGATTCCTGCCAGATTTGCCGGGGTGCTGCTTGCTCTGGCCCTCATTTTGCCAGGGACC
CTTTGTGCAGAAGGAACTCGCGGCAGGTCATCCACGGCCCGATGCAGCCTTTTCGGAAGT
GACTTCGTCAACACCTTTGATGGGAGCATGTACAGCTTTGCGGGATACTGCAGTTACCTC
CTGGCAGGGGGCTGCCAGAAACGCTCCTTCTCGATTATTGGGGACTTCCAGAATGGCAAG
AGAGTGAGCCTCTCCGTGTATCTTGGGGAATTTTTTGACATCCATTTGTTTGTCAATGGT
ACCGTGACACAGGGGGACCAAAGAGTCTCCATGCCCTATGCCTCCAAAGGGCTGTATCTA
GAAACTGAGGCTGGGTACTACAAGCTGTCCGGTGAGGCCTATGGCTTTGTGGCCAGGATC
GATGGCAGCGGCAACTTTCAAGTCCTGCTGTCAGACAGATACTTCAACAAGACCTGCGGG
CTGTGTGGCAACTTTAACATCTTTGCTGAAGATGACTTTATGACCCAAGAAGGGACCTTG
ACCTCGGACCCTTATGACTTTGCCAACTCATGGGCTCTGAGCAGTGGAGAACAGTGGTGT
GAACGGGCATCTCCTCCCAGCAGCTCATGCAACATCTCCTCTGGGGAAATGCAGAAGGGC
CTGTGGGAGCAGTGCCAGCTTCTGAAGAGCACCTCGGTGTTTGCCCGCTGCCACCCTCTG
GTGGACCCCGAGCCTTTTGTGGCCCTGTGTGAGAAGACTTTGTGTGAGTGTGCTGGGGGG
CTGGAGTGCGCCTGCCCTGCCCTCCTGGAGTACGCCCGGACCTGTGCCCAGGAGGGAATG
GTGCTGTACGGCTGGACCGACCACAGCGCGTGCAGCCCAGTGTGCCCTGCTGGTATGGAG
TATAGGCAGTGTGTGTCCCCTTGCGCCAGGACCTGCCAGAGCCTGCACATCAATGAAATG
TGTCAGGAGCGATGCGTGGATGGCTGCAGCTGCCCTGAGGGACAGCTCCTGGATGAAGGC
CTCTGCGTGGAGAGCACCGAGTGTCCCTGCGTGCATTCCGGAAAGCGCTACCCTCCCGGC
ACCTCCCTCTCTCGAGACTGCAACACCTGCATTTGCCGAAACAGCCAGTGGATCTGCAGC
AATGAAGAATGTCCAGGGGAGTGCCTTGTCACAGGTCAATCACACTTCAAGAGCTTTGAC
AACAGATACTTCACCTTCAGTGGGATCTGCCAGTACCTGCTGGCCCGGGATTGCCAGGAC
CACTCCTTCTCCATTGTCATTGAGACTGTCCAGTGTGCTGATGACCGCGACGCTGTGTGC
ACCCGCTCCGTCACCGTCCGGCTGCCTGGCCTGCACAACAGCCTTGTGAAACTGAAGCAT
GGGGCAGGAGTTGCCATGGATGGCCAGGACGTCCAGCTCCCCCTCCTGAAAGGTGACCTC
CGCATCCAGCATACAGTGACGGCCTCCGTGCGCCTCAGCTACGGGGAGGACCTGCAGATG
GACTGGGATGGCCGCGGGAGGCTGCTGGTGAAGCTGTCCCCCGTCTATGCCGGGAAGACC
TGCGGCCTGTGTGGGAATTACAATGGCAACCAGGGCGACGACTTCCTTACCCCCTCTGGG
CTGGCGGAGCCCCGGGTGGAGGACTTCGGGAACGCCTGGAAGCTGCACGGGGACTGCCAG
GACCTGCAGAAGCAGCACAGCGATCCCTGCGCCCTCAACCCGCGCATGACCAGGTTCTCC
GAGGAGGCGTGCGCGGTCCTGACGTCCCCCACATTCGAGGCCTGCCATCGTGCCGTCAGC
CCGCTGCCCTACCTGCGGAACTGCCGCTACGACGTGTGCTCCTGCTCGGACGGCCGCGAG
TGCCTGTGCGGCGCCCTGGCCAGCTATGCCGCGGCCTGCGCGGGGAGAGGCGTGCGCGTC
GCGTGGCGCGAGCCAGGCCGCTGTGAGCTGAACTGCCCGAAAGGCCAGGTGTACCTGCAG
TGCGGGACCCCCTGCAACCTGACCTGCCGCTCTCTCTCTTACCCGGATGAGGAATGCAAT
GAGGCCTGCCTGGAGGGCTGCTTCTGCCCCCCAGGGCTCTACATGGATGAGAGGGGGGAC
TGCGTGCCCAAGGCCCAGTGCCCCTGTTACTATGACGGTGAGATCTTCCAGCCAGAAGAC
ATCTTCTCAGACCATCACACCATGTGCTACTGTGAGGATGGCTTCATGCACTGTACCATG
AGTGGAGTCCCCGGAAGCTTGCTGCCTGACGCTGTCCTCAGCAGTCCCCTGTCTCATCGC
AGCAAAAGGAGCCTATCCTGTCGGCCCCCCATGGTCAAGCTGGTGTGTCCCGCTGACAAC
CTGCGGGCTGAAGGGCTCGAGTGTACCAAAACGTGCCAGAACTATGACCTGGAGTGCATG
AGCATGGGCTGTGTCTCTGGCTGCCTCTGCCCCCCGGGCATGGTCCGGCATGAGAACAGA
TGTGTGGCCCTGGAAAGGTGTCCCTGCTTCCATCAGGGCAAGGAGTATGCCCCTGGAGAA
ACAGTGAAGATTGGCTGCAACACTTGTGTCTGTCGGGACCGGAAGTGGAACTGCACAGAC
CATGTGTGTGATGCCACGTGCTCCACGATCGGCATGGCCCACTACCTCACCTTCGACGGG
CTCAAATACCTGTTCCCCGGGGAGTGCCAGTACGTTCTGGTGCAGGATTACTGCGGCAGT
AACCCTGGGACCTTTCGGATCCTAGTGGGGAATAAGGGATGCAGCCACCCCTCAGTGAAA
TGCAAGAAACGGGTCACCATCCTGGTGGAGGGAGGAGAGATTGAGCTGTTTGACGGGGAG
GTGAATGTGAAGAGGCCCATGAAGGATGAGACTCACTTTGAGGTGGTGGAGTCTGGCCGG
TACATCATTCTGCTGCTGGGCAAAGCCCTCTCCGTGGTCTGGGACCGCCACCTGAGCATC
TCCGTGGTCCTGAAGCAGACATACCAGGAGAAAGTGTGTGGCCTGTGTGGGAATTTTGAT
GGCATCCAGAACAATGACCTCACCAGCAGCAACCTCCAAGTGGAGGAAGACCCTGTGGAC
TTTGGGAACTCCTGGAAAGTGAGCTCGCAGTGTGCTGACACCAGAAAAGTGCCTCTGGAC
TCATCCCCTGCCACCTGCCATAACAACATCATGAAGCAGACGATGGTGGATTCCTCCTGT
AGAATCCTTACCAGTGACGTCTTCCAGGACTGCAACAAGCTGGTGGACCCCGAGCCATAT
CTGGATGTCTGCATTTACGACACCTGCTCCTGTGAGTCCATTGGGGACTGCGCCTGCTTC
TGCGACACCATTGCTGCCTATGCCCACGTGTGTGCCCAGCATGGCAAGGTGGTGACCTGG
AGGACGGCCACATTGTGCCCCCAGAGCTGCGAGGAGAGGAATCTCCGGGAGAACGGGTAT
GAGTGTGAGTGGCGCTATAACAGCTGTGCACCTGCCTGTCAAGTCACGTGTCAGCACCCT
GAGCCACTGGCCTGCCCTGTGCAGTGTGTGGAGGGCTGCCATGCCCACTGCCCTCCAGGG
AAAATCCTGGATGAGCTTTTGCAGACCTGCGTTGACCCTGAAGACTGTCCAGTGTGTGAG
GTGGCTGGCCGGCGTTTTGCCTCAGGAAAGAAAGTCACCTTGAATCCCAGTGACCCTGAG
CACTGCCAGATTTGCCACTGTGATGTTGTCAACCTCACCTGTGAAGCCTGCCAGGAGCCG
GGAGGCCTGGTGGTGCCTCCCACAGATGCCCCGGTGAGCCCCACCACTCTGTATGTGGAG
GACATCTCGGAACCGCCGTTGCACGATTTCTACTGCAGCAGGCTACTGGACCTGGTCTTC
CTGCTGGATGGCTCCTCCAGGCTGTCCGAGGCTGAGTTTGAAGTGCTGAAGGCCTTTGTG
GTGGACATGATGGAGCGGCTGCGCATCTCCCAGAAGTGGGTCCGCGTGGCCGTGGTGGAG
TACCACGACGGCTCCCACGCCTACATCGGGCTCAAGGACCGGAAGCGACCGTCAGAGCTG
CGGCGCATTGCCAGCCAGGTGAAGTATGCGGGCAGCCAGGTGGCCTCCACCAGCGAGGTC
TTGAAATACACACTGTTCCAAATCTTCAGCAAGATCGACCGCCCTGAAGCCTCCCGCATC
GCCCTGCTCCTGATGGCCAGCCAGGAGCCCCAACGGATGTCCCGGAACTTTGTCCGCTAC
GTCCAGGGCCTGAAGAAGAAGAAGGTCATTGTGATCCCGGTGGGCATTGGGCCCCATGCC
AACCTCAAGCAGATCCGCCTCATCGAGAAGCAGGCCCCTGAGAACAAGGCCTTCGTGCTG
AGCAGTGTGGATGAGCTGGAGCAGCAAAGGGACGAGATCGTTAGCTACCTCTGTGACCTT
GCCCCTGAAGCCCCTCCTCCTACTCTGCCCCCCCACATGGCACAAGTCACTGTGGGCCCG
GGGCTCTTGGGGGTTTCGACCCTGGGGCCCAAGAGGAACTCCATGGTTCTGGATGTGGCG
TTCGTCCTGGAAGGATCGGACAAAATTGGTGAAGCCGACTTCAACAGGAGCAAGGAGTTC
ATGGAGGAGGTGATTCAGCGGATGGATGTGGGCCAGGACAGCATCCACGTCACGGTGCTG
CAGTACTCCTACATGGTGACCGTGGAGTACCCCTTCAGCGAGGCACAGTCCAAAGGGGAC
ATCCTGCAGCGGGTGCGAGAGATCCGCTACCAGGGCGGCAACAGGACCAACACTGGGCTG
GCCCTGCGGTACCTCTCTGACCACAGCTTCTTGGTCAGCCAGGGTGACCGGGAGCAGGCG
CCCAACCTGGTCTACATGGTCACCGGAAATCCTGCCTCTGATGAGATCAAGAGGCTGCCT
GGAGACATCCAGGTGGTGCCCATTGGAGTGGGCCCTAATGCCAACGTGCAGGAGCTGGAG
AGGATTGGCTGGCCCAATGCCCCTATCCTCATCCAGGACTTTGAGACGCTCCCCCGAGAG
GCTCCTGACCTGGTGCTGCAGAGGTGCTGCTCCGGAGAGGGGCTGCAGATCCCCACCCTC
TCCCCTGCACCTGACTGCAGCCAGCCCCTGGACGTGATCCTTCTCCTGGATGGCTCCTCC
AGTTTCCCAGCTTCTTATTTTGATGAAATGAAGAGTTTCGCCAAGGCTTTCATTTCAAAA
GCCAATATAGGGCCTCGTCTCACTCAGGTGTCAGTGCTGCAGTATGGAAGCATCACCACC
ATTGACGTGCCATGGAACGTGGTCCCGGAGAAAGCCCATTTGCTGAGCCTTGTGGACGTC
ATGCAGCGGGAGGGAGGCCCCAGCCAAATCGGGGATGCCTTGGGCTTTGCTGTGCGATAC
TTGACTTCAGAAATGCATGGTGCCAGGCCGGGAGCCTCAAAGGCGGTGGTCATCCTGGTC
ACGGACGTCTCTGTGGATTCAGTGGATGCAGCAGCTGATGCCGCCAGGTCCAACAGAGTG
ACAGTGTTCCCTATTGGAATTGGAGATCGCTACGATGCAGCCCAGCTACGGATCTTGGCA
GGCCCAGCAGGCGACTCCAACGTGGTGAAGCTCCAGCGAATCGAAGACCTCCCTACCATG
GTCACCTTGGGCAATTCCTTCCTCCACAAACTGTGCTCTGGATTTGTTAGGATTTGCATG
GATGAGGATGGGAATGAGAAGAGGCCCGGGGACGTCTGGACCTTGCCAGACCAGTGCCAC
ACCGTGACTTGCCAGCCAGATGGCCAGACCTTGCTGAAGACTCATCGGGTCAACTGTGAC
CGGGGGCTGAGGCCTTCGTGCCCTAACAGCCAGTCCCCTGTTAAAGTGGAAGAGACCTGT
GGCTGCCGCTGGACCTGCCCCTGCGTGTGCACAGGCAGCTCCACTCGGCACATCGTGACC
TTTGATGGGCAGAATTTCAAGCTGACTGGCAGCTGTTCTTATGTCCTATTTCAAAACAAG
GAGCAGGACCTGGAGGTGATTCTCCATAATGGTGCCTGCAGCCCTGGAGCAAGGCAGGGC
TGCATGAAATCCATCGAGGTGAAGCACAGTGCCCTCTCCGTCGAGCTGCACAGTGACATG
GAGGTGACGGTGAATGGGAGACTGGTCTCTGTTCCTTACGTGGGTGGGAACATGGAAGTC
AACGTTTATGGTGCCATCATGCATGAGGTCAGATTCAATCACCTTGGTCACATCTTCACA
TTCACTCCACAAAACAATGAGTTCCAACTGCAGCTCAGCCCCAAGACTTTTGCTTCAAAG
ACGTATGGTCTGTGTGGGATCTGTGATGAGAACGGAGCCAATGACTTCATGCTGAGGGAT
GGCACAGTCACCACAGACTGGAAAACACTTGTTCAGGAATGGACTGTGCAGCGGCCAGGG
CAGACGTGCCAGCCCATCCTGGAGGAGCAGTGTCTTGTCCCCGACAGCTCCCACTGCCAG
GTCCTCCTCTTACCACTGTTTGCTGAATGCCACAAGGTCCTGGCTCCAGCCACATTCTAT
GCCATCTGCCAGCAGGACAGTTGCCACCAGGAGCAAGTGTGTGAGGTGATCGCCTCTTAT
GCCCACCTCTGTCGGACCAACGGGGTCTGCGTTGACTGGAGGACACCTGATTTCTGTGCT
ATGTCATGCCCACCATCTCTGGTCTACAACCACTGTGAGCATGGCTGTCCCCGGCACTGT
GATGGCAACGTGAGCTCCTGTGGGGACCATCCCTCCGAAGGCTGTTTCTGCCCTCCAGAT
AAAGTCATGTTGGAAGGCAGCTGTGTCCCTGAAGAGGCCTGCACTCAGTGCATTGGTGAG
GATGGAGTCCAGCACCAGTTCCTGGAAGCCTGGGTCCCGGACCACCAGCCCTGTCAGATC
TGCACATGCCTCAGCGGGCGGAAGGTCAACTGCACAACGCAGCCCTGCCCCACGGCCAAA
GCTCCCACGTGTGGCCTGTGTGAAGTAGCCCGCCTCCGCCAGAATGCAGACCAGTGCTGC
CCCGAGTATGAGTGTGTGTGTGACCCAGTGAGCTGTGACCTGCCCCCAGTGCCTCACTGT
GAACGTGGCCTCCAGCCCACACTGACCAACCCTGGCGAGTGCAGACCCAACTTCACCTGC
GCCTGCAGGAAGGAGGAGTGCAAAAGAGTGTCCCCACCCTCCTGCCCCCCGCACCGTTTG
CCCACCCTTCGGAAGACCCAGTGCTGTGATGAGTATGAGTGTGCCTGCAACTGTGTCAAC
TCCACAGTGAGCTGTCCCCTTGGGTACTTGGCCTCAACCGCCACCAATGACTGTGGCTGT
ACCACAACCACCTGCCTTCCCGACAAGGTGTGTGTCCACCGAAGCACCATCTACCCTGTG
GGCCAGTTCTGGGAGGAGGGCTGCGATGTGTGCACCTGCACCGACATGGAGGATGCCGTG
ATGGGCCTCCGCGTGGCCCAGTGCTCCCAGAAGCCCTGTGAGGACAGCTGTCGGTCGGGC
TTCACTTACGTTCTGCATGAAGGCGAGTGCTGTGGAAGGTGCCTGCCATCTGCCTGTGAG
GTGGTGACTGGCTCACCGCGGGGGGACTCCCAGTCTTCCTGGAAGAGTGTCGGCTCCCAG
TGGGCCTCCCCGGAGAACCCCTGCCTCATCAATGAGTGTGTCCGAGTGAAGGAGGAGGTC
TTTATACAACAAAGGAACGTCTCCTGCCCCCAGCTGGAGGTCCCTGTCTGCCCCTCGGGC
TTTCAGCTGAGCTGTAAGACCTCAGCGTGCTGCCCAAGCTGTCGCTGTGAGCGCATGGAG
GCCTGCATGCTCAATGGCACTGTCATTGGGCCCGGGAAGACTGTGATGATCGATGTGTGC
ACGACCTGCCGCTGCATGGTGCAGGTGGGGGTCATCTCTGGATTCAAGCTGGAGTGCAGG
AAGACCACCTGCAACCCCTGCCCCCTGGGTTACAAGGAAGAAAATAACACAGGTGAATGT
TGTGGGAGATGTTTGCCTACGGCTTGCACCATTCAGCTAAGAGGAGGACAGATCATGACA
CTGAAGCGTGATGAGACGCTCCAGGATGGCTGTGATACTCACTTCTGCAAGGTCAATGAG
AGAGGAGAGTACTTCTGGGAGAAGAGGGTCACAGGCTGCCCACCCTTTGATGAACACAAG
TGTCTGGCTGAGGGAGGTAAAATTATGAAAATTCCAGGCACCTGCTGTGACACATGTGAG
GAGCCTGAGTGCAACGACATCACTGCCAGGCTGCAGTATGTCAAGGTGGGAAGCTGTAAG
TCTGAAGTAGAGGTGGATATCCACTACTGCCAGGGCAAATGTGCCAGCAAAGCCATGTAC
TCCATTGACATCAACGATGTGCAGGACCAGTGCTCCTGCTGCTCTCCGACACGGACGGAG
CCCATGCAGGTGGCCCTGCACTGCACCAATGGCTCTGTTGTGTACCATGAGGTTCTCAAT
GCCATGGAGTGCAAATGCTCCCCCAGGAAGTGCAGCAAGTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
X04385

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_6_Locus:
12p13.3

# Macromolecular_Interacting_Partner_6_SNPs:
rs1800378; rs1063856; rs216321; rs216311; rs1800385; rs7962217; rs11537643; rs16932374; rs34230288; rs1800387; rs1800383; rs216902; rs216310; rs1800376; rs1063857; rs2228319; rs7312411; rs216867; rs1800375; rs1800384; rs2229444; rs1800380; rs16933969; rs10849371; rs2286608; rs216301; rs216853; rs216328; rs980130; rs216894; rs2239138; rs216889; rs723188; rs216290; rs216313; rs216322; rs216887; rs216309; rs216891; rs2238109; rs216883; rs216896; rs917858; rs1860365; rs216856; rs2109119; rs3782711; rs4764521; rs216331; rs933408; rs216901; rs216318; rs7955850; rs216335; rs216340; rs216329; rs11611917; rs2239156; rs216312; rs216903; rs2058223; rs7133777; rs10849377; rs216809; rs917859; rs4764482; rs11063996; rs216905; rs917857; rs216292; rs11063997; rs7964799; rs2283333; rs723190; rs7969672; rs216893; rs2239157; rs1159993; rs4764478; rs1005251; rs2270152; rs723189; rs7135976; rs2058220; rs216805; rs2286646; rs11609728; rs10849375; rs216872; rs11609696; rs2238103; rs216307; rs2270151; rs3759320; rs3759321; rs12832252; rs11615001; rs216904; rs11063998; rs11614912; rs2239139; rs2239145; rs7968035; rs216873; rs7958883; rs10849378; rs11610629; rs216291; rs980131; rs216320; rs763581; rs11064003; rs2238104; rs216303; rs9645765; rs10466904; rs2239147; rs11608550; rs216811; rs2239140; rs11837434; rs7961844; rs24177; rs216293; rs6489686; rs12829271; rs216306; rs2363309; rs980134; rs7314208; rs216886; rs1860416; rs216323; rs216298; rs216804; rs7954351; rs2270239; rs216295; rs216333; rs1558519; rs216890; rs2239142; rs17491334; rs7967155; rs11064021; rs2070887; rs11836843; rs216802; rs216874; rs2238101; rs216897; rs2058473; rs11612370; rs216860; rs216305; rs3782716; rs12300917; rs16932408; rs1558520; rs216336; rs11833733; rs3213721; rs216338; rs2239159; rs12319392; rs1034933; rs216326; rs7965754; rs11608587; rs216800; rs12099542; rs7308002; rs7136463; rs12307072; rs2058222; rs216880; rs12317523; rs11063955; rs12317079; rs216810; rs11831654; rs6489685; rs7139057; rs2238110; rs11064024; rs177702; rs216302; rs12369177; rs542993; rs2283332; rs11609815; rs1860366; rs2239144; rs11612401; rs2239158; rs11064018; rs7964554; rs216330; rs4764483; rs10774391; rs216332; rs10849362; rs2238112; rs12423243; rs3819537; rs2885752; rs2109118; rs10849385; rs216337; rs12306928; rs216895; rs216300; rs2885749; rs2532859; rs10849380; rs216868; rs11064004; rs1582297; rs216327; rs763580; rs10849361; rs216801; rs216852; rs12368267; rs7965760; rs216304; rs2239162; rs10849376; rs10774387; rs1610055; rs6489691; rs2239154; rs11614545; rs216854; rs11836708; rs216315; rs11063995; rs11831449; rs11613586; rs10849363; rs216898; rs3819541; rs7301070; rs2283331; rs216881; rs4586226; rs216855; rs4764480; rs17419697; rs11063965; rs11608525; rs4764535; rs362255; rs541011; rs216888; rs11829713; rs4764531; rs12831864; rs10849381; rs11063991; rs11064000; rs2236774; rs11063976; rs12297370; rs216314; rs7312746; rs2239137; rs17491320; rs11063956; rs11064033; rs216308; rs10849365; rs2239150; rs7955254; rs10849360; rs11608523; rs11063954; rs11063999; rs2239161; rs3819540; rs2238102; rs1860367; rs2239149; rs11064005; rs10849383; rs4764536; rs7314094; rs10849367; rs1990491; rs10774389; rs216806; rs12366887; rs12368045; rs216297; rs6489693; rs7979264; rs216858; rs11063958; rs3819538; rs11063977; rs10744696; rs11063962; rs2238105; rs7964013; rs2885753; rs11063974; rs1579229; rs216865; rs7315478; rs216884; rs188616; rs7303727; rs6489692; rs7305616; rs7313679; rs7315124; rs769080; rs2239152; rs3765645; rs216316; rs10774388; rs11835809; rs2013307; rs12367254; rs11829469; rs7970924; rs7298566; rs10849369; rs11064019; rs12368446; rs669667; rs2283335; rs216299; rs12423482; rs7301911; rs216870; rs11615036; rs11614772; rs11611805; rs216882; rs2012829; rs12304995; rs216892; rs11829972; rs170048; rs2286937; rs216325; rs11608666; rs526881; rs11064008; rs11063990; rs11614724; rs11063964; rs7956179; rs11615182; rs12307883; rs12829220; rs2109122; rs7314380; rs11613839; rs541012; rs2362483; rs10849364; rs11832009; rs526861; rs1814249; rs11612384; rs12366600; rs12297442; rs12366917; rs216877; rs28365811; rs7980758; rs7976222; rs13377953; rs2239141; rs11063961; rs216294; rs11064029; rs4764532; rs7133457; rs216334; rs28455627; rs12319292; rs216878; rs10849370; rs7298568; rs11835829; rs7306354; rs11615208; rs980133; rs12315477; rs7957672; rs10849379; rs7980753; rs2854866; rs216319; rs216866; rs10849382; rs11064020; rs12305676; rs2191161; rs216803; rs11610548; rs7305522; rs2363329; rs962613; rs1610056; rs12319598; rs4348960; rs11836182; rs11063957; rs7953373; rs216861; rs216857; rs3782715; rs11830385; rs2238106; rs2239155; rs917569; rs11829480; rs10849374; rs11063953; rs2236773; rs7133854; rs4764534; rs2283330; rs11611549; rs7136872; rs2239146; rs11611899; rs2239160; rs2070886; rs7306706; rs7135258; rs12579603; rs10849368; rs7135039; rs4408361; rs11613674; rs1814250; rs12810426; rs183356; rs1860415; rs3741906; rs917568; rs11063959; rs216885; rs216871; rs2005829; rs11064010; rs4764527; rs216339; rs12307110; rs7309514; rs2239148; rs7961290; rs11064014; rs16932406; rs1990318; rs216808; rs12427346; rs190055; rs11064025; rs9634155; rs2239153; rs7961998; rs12367255; rs11616181; rs11063971; rs10849366; rs216317; rs7968888; rs12310690; rs2286938; rs216296; rs499648; rs4764533; rs12371825; rs2362482; rs216879; rs10437830; rs1860364; rs11064031; rs2239143; rs17491418; rs11063981; rs11611919; rs2239151; rs7975429; rs11064022; rs2070883; rs11614723; rs3887143; rs216812; rs7976955; rs1990326; rs10849358; rs7964777; rs7965413; rs7966230; rs7954855; rs35335161; rs5020485; rs33978901; rs11063988; rs1800386; rs1800377; rs35879738; rs11063987; rs34120165; rs11064002; rs11837584; rs11064012; rs41276738; rs2229448; rs35365059; rs1800381; rs41276736; rs11537642; rs34510401; rs35302737; rs4021576; rs35191786; rs34237676; rs41276732; rs16932285; rs3741908; rs3087517; rs2363337; rs10656576; rs35414262; rs10577899; rs11064015; rs35881119; rs12826055; rs4021577; rs7485251; rs5796203; rs7137165; rs12307335; rs4021567; rs811626; rs3782713; rs2854869; rs980132; rs12311371; rs11063960; rs16932350; rs35309907; rs28853276; rs1092092; rs16932345; rs34433330; rs28440903; rs10579907; rs34800208; rs2363331; rs4021585; rs4485164; rs4021579; rs216875; rs28532342; rs34777802; rs35842350; rs35807919; rs4021583; rs5796201; rs12302827; rs34479155; rs11063952; rs4764528; rs7308549; rs7961539; rs2363318; rs11064023; rs35398077; rs11064013; rs2238111; rs11615660; rs11534812; rs35115059; rs2070885; rs3062519; rs28630679; rs34253435; rs11838266; rs28365810; rs41299142; rs35701639; rs10532498; rs34814252; rs2363324; rs887313; rs34536486; rs36007563; rs34789291; rs2058221; rs34927887; rs216864; rs4491293; rs35194208; rs2854870; rs12313683; rs35434595; rs4021561; rs11267365; rs11390977; rs35950632; rs1092458; rs4021581; rs7295164; rs4995110; rs35265805; rs34518634; rs7957068; rs216859; rs10612315; rs495993; rs35073786; rs34082724; rs34337426; rs11386491; rs2363327; rs5796198; rs34115770; rs35136562; rs34977515; rs41405848; rs12310306; rs7961414; rs41276734; rs28369596; rs11064030; rs1088313; rs4021589; rs2363322; rs41320652; rs7306992; rs35426627; rs1091316; rs34260060; rs3819539; rs4021590; rs28464116; rs4021580; rs11064028; rs12301865; rs2537900; rs10609189; rs5796207; rs5796200; rs11063968; rs4021575; rs34584762; rs34791317; rs34933632; rs11614846; rs7955037; rs7398722; rs216862; rs11830320; rs2363334; rs34219825; rs11282431; rs34653249; rs3782714; rs11829058; rs34741728; rs36067650; rs3216178; rs3952284; rs35124526; rs2854867; rs11349246; rs12311305; rs2363319; rs7960061; rs28393881; rs35240575; rs808842; rs11064032; rs10466914; rs2363320; rs4021562; rs2238107; rs34823799; rs11064011; rs216869; rs4021573; rs2363330; rs12299946; rs35465198; rs5796205; rs11451166; rs10650518; rs12826868; rs11063982; rs1088312; rs34238471; rs35399776; rs11063972; rs5796202; rs11281788; rs7485252; rs216813; rs28668954; rs4021587; rs28453687; rs35992766; rs216899; rs7294888; rs35065931; rs34715921; rs12308867; rs11063966; rs3855635; rs34000420; rs10626383; rs4021578; rs12229676; rs7969518; rs12302625; rs34953346; rs11064001; rs3841765; rs35092951; rs34668268; rs7137497; rs11063992; rs4021565; rs34654480; rs10559016; rs35402978; rs2363326; rs4021586; rs216863; rs4460858; rs4021571; rs12827149; rs35551203; rs2363332; rs28758444; rs34404369; rs2159367; rs7295375; rs4021564; rs11429073; rs11063986; rs3062521; rs34547698; rs3062550; rs7138256; rs2192205; rs12297467; rs35926634; rs35928031; rs11063970; rs10577898; rs7397354; rs10667514; rs3952285; rs5796206; rs2363323; rs12315340; rs34507028; rs34386173; rs36100099; rs2070884; rs34071955; rs34277620; rs11268064; rs3782712; rs811625; rs11063963; rs7300389; rs12369181; rs4021584; rs11064027; rs6489694; rs35685925; rs11272545; rs2854871; rs4021574; rs11614865; rs1091315; rs5796209; rs2363333; rs1014389; rs216876; rs11064009; rs35815182; rs11063978; rs3835346; rs34683816; rs11313234; rs10535241; rs34422091; rs11277921; rs7307604; rs3952283; rs34748107; rs41402545; rs11063975; rs11616023; rs11063994; rs216900; rs34781501; rs4021582; rs34791860; rs12146791; rs11613273; rs12578406; rs11064016; rs34737437; rs7485058; rs4021569; rs35395014; rs3837511; rs5796204; rs35649118; rs5796199; rs11367712; rs4764537; rs12309308; rs7965698; rs2191160; rs12827774; rs34140032; rs2854868; rs34444862; rs11064034; rs216851; rs7980045; rs35311176; rs7131844; rs12368821; rs12810526; rs41276742; rs34877178; rs216814; rs12811229; rs11063993; rs216324; rs11063969; rs35802767; rs34989239; rs35473417; rs3062626; rs4008536; rs10622288; rs10219599; rs12813828; rs35829863; rs4495941; rs10459136; rs34998513; rs11063973; rs34635540; rs35254301; rs34170963; rs2363321; rs12819922; rs2363328; rs4764479; rs35972283; rs5796208; rs12099866; rs35040508; rs35122657; rs4021563; rs2159365; rs4021588; rs41388848; rs35671535; rs36077772; rs4021572; rs28504205; rs10532499; rs41276740; rs34443871; rs9989051; rs216807; rs7135169; rs12307884; rs1833134; rs11063967; rs34870498; rs34015284; rs34711844; rs2363325; rs10657127; rs797612; rs34880765; rs34871897; rs11609998; rs3841766; rs7138396; rs34883360; rs35727526; rs11064017; rs35426337; rs808841; rs34220049; rs28365812; rs12826041; rs10656544; rs34951813; rs12302573; rs11615632; rs10532497; rs1610057; rs12227091; rs809514; rs7964010; rs2238108; rs4021570; rs10622633; rs34637418; rs11064007; rs3858686; rs28369235; rs35295594; rs1088314; rs11611247; rs10466903; rs6144598; rs41496447; rs12311643; rs11397409; rs34794268; rs7979300; rs36115023; rs10667650; rs2839721; rs35501232; rs12830421; rs7965425; rs12315619; rs34201373; rs35679344; rs34575095; rs35230054; rs34625593; rs10774394; rs10774398; rs10849387; rs10849391; rs11063943; rs11063944; rs11063945; rs11063951; rs12367467; rs12422307; rs12580835; rs2362481; rs2885517; rs3809241; rs3809242; rs6416321; rs7314566; rs7956269; rs7956772; rs7960314; rs7963244

# Macromolecular_Interacting_Partner_6_General_References:
3489923; 2584182; 3019665; 2828057; 3495266; 3524673; 2864688; 12665801; 3488076; 1988024; 3874428; 3873280; 3875078; 3496594; 10961880; 3502076; 3089784; 9553097; 9331419; 9312128; 12871266; 2786201; 1673047; 1832934; 1761120; 2010538; 1672694; 2011604; 1906179; 1729889; 1420817; 1419803; 1419804; 1429668; 1409710; 8338947; 8435341; 8348943; 8376405; 8486782; 8123843; 8123844; 8088787; 7989040; 8011991; 7620154; 7734373; 8547152; 7789955; 8622978; 10887119

# Macromolecular_Interacting_Partner_6_References:
10713323; 12871332

# Macromolecular_Interacting_Partner_7_ID:
7577

# Macromolecular_Interacting_Partner_7_Name:
Calcitonin gene-related peptide 1 precursor

# Macromolecular_Interacting_Partner_7_Synonyms:
Calcitonin gene-related peptide I; CGRP-I; Alpha-type CGRP

# Macromolecular_Interacting_Partner_7_Gene_Name:
CALCA

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Calcitonin generelated peptide 1 precursor
MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQ
MKASELEQEQEREGSRIIAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFG
RRRRDLQA

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
128

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
13899

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
9.40

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00214:Calc_CGRP_IAPP

# Macromolecular_Interacting_Partner_7_Signals:
1-25

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
179828

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
CALCA_HUMAN (P06881)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
CALCA

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
CALCA

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:1437

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>387 bp
ATGGGCTTCCAAAAGTTCTCCCCCTTCCTGGCTCTCAGCATCTTGGTCCTGTTGCAGGCA
GGCAGCCTCCATGCAGCACCATTCAGGTCTGCCCTGGAGAGCAGCCCAGCAGACCCGGCC
ACGCTCAGTGAGGACGAAGCGCGCCTCCTGCTGGCTGCACTGGTGCAGGACTATGTGCAG
ATGAAGGCCAGTGAGCTGGAGCAGGAGCAAGAGAGAGAGGGCTCCAGAATCATTGCCCAG
AAGAGAGCCTGTGACACTGCCACCTGTGTGACTCATCGGCTGGCAGGCTTGCTGAGCAGA
TCAGGGGGTGTGGTGAAGAACAACTTTGTGCCCACCAATGTGGGTTCCAAAGCCTTTGGC
AGGCGCCGCAGGGACCTTCAAGCCTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
M12667

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_7_Locus:
11p15.2-p15.1

# Macromolecular_Interacting_Partner_7_SNPs:
rs13306224; rs5241; rs5239; rs5240; rs5242; rs2956; rs7110615; rs5237; rs5243; rs2644690; rs35815751; rs5238; rs11607133; rs34901084; rs7925191; rs34294892; rs35212698; rs35909067; rs34815547; rs35731970; rs3758761; rs11023401; rs3781719; rs3781718; rs1553005; rs35365543; rs924099; rs11826691; rs11023400; rs34414857; rs34164367; rs34587547; rs34670162; rs2644689; rs35709504; rs35425520; rs7124346; rs2644687; rs34896084; rs35943755; rs35096144; rs2644688; rs13306223; rs2856867; rs34200140; rs35996804; rs35356387; rs34603621; rs34488736; rs35780811; rs2856866; rs1010042; rs12576047; rs34252928; rs2071411; rs7114837; rs34692826; rs7128563; rs28420578; rs12361439; rs34468174; rs13306225; rs11821926; rs1908683; rs34166188; rs35006116; rs35676062; rs35096190; rs12800646; rs35955129; rs35481990; rs28494031; rs34691228; rs12800297; rs12225355; rs12800139; rs34596504; rs1027425; rs1027426; rs1027427; rs10832338; rs11023403; rs11608134; rs11821055; rs11825513; rs11827349; rs1496163; rs1496166; rs16930769; rs16930770; rs16930784; rs17503142; rs763363; rs7929159; rs7948017; rs903808

# Macromolecular_Interacting_Partner_7_General_References:
3872459; 2571128; 6148938; 2408883; 6610687; 3034287; 6609312; 3492492; 1318039; 1988044; 2039456

# Macromolecular_Interacting_Partner_7_References:
1581336

# Macromolecular_Interacting_Partner_8_ID:
7010

# Macromolecular_Interacting_Partner_8_Name:
Proactivator polypeptide precursor [Contains: Saposin A

# Macromolecular_Interacting_Partner_8_Synonyms:
Protein A; Saposin B-Val; Saposin B; Sphingolipid activator protein 1; SAP-1; Cerebroside sulfate activator; CSAct; Dispersin; Sulfatide/GM1 activator; Saposin C; Co-beta-glucosidase; A1 activator; Glucosylceramidase activator; Sphingolipid activator protein 2; SAP-2; Saposin D; Protein C; Component C]

# Macromolecular_Interacting_Partner_8_Gene_Name:
PSAP

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Proactivator polypeptide precursor Contains: Saposin 
AMYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVK
SLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILD
IIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLL
YPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMAD
ICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELV
EPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQE
VVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYL
DRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKI
GACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
524

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
58113

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
4.82

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  sphingolipid metabolism
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  vacuole
Component:  lytic vacuole
Component:  lysosome

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Saposin D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12)

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF02199:SapA;
PF05184:SapB_1;
PF03489:SapB_2

# Macromolecular_Interacting_Partner_8_Signals:
1-16

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
220064

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
SAP_HUMAN (P07602)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
PSAP

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
PSAP

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:9498

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Lysosome

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1584 bp
ATGTACGCCCTCTTCCTCCTGGCCAGCCTCCTGGGCGCGGCTCTAGCCGGCCCGGTCCTT
GGACTGAAAGAATGCACCAGGGGCTCGGCAGTGTGGTGCCAGAATGTGAAGACGGCGTCC
GACTGCGGGGCAGTGAAGCACTGCCTGCAGACCGTTTGGAACAAGCCAACAGTGAAATCC
CTTCCCTGCGACATATGCAAAGACGTTGTCACCGCAGCTGGTGATATGCTGAAGGACAAT
GCCACTGAGGAGGAGATCCTTGTTTACTTGGAGAAGACCTGTGACTGGCTTCCGAAACCG
AACATGTCTGCTTCATGCAAGGAGATAGTGGACTCCTACCTCCCTGTCATCCTGGACATC
ATTAAAGGAGAAATGAGCCGTCCTGGGGAGGTGTGCTCTGCTCTCAACCTCTGCGAGTCT
CTCCAGAAGCACCTAGCAGAGCTGAATCACCAGAAGCAGCTGGAGTCCAATAAGATCCCA
GAGCTGGACATGACTGAGGTGGTGGCCCCCTTCATGGCCAACATCCCTCTCCTCCTCTAC
CCTCAGGACGGCCCCCGCAGCAAGCCCCAGCCAAAGGATAATGGGGACGTTTGCCAGGAC
TGCATTCAGATGGTGACTGACATCCAGACTGCTGTACGGACCAACTCCACCTTTGTCCAG
GCCTTGGTGGAACATGTCAAGGAGGAGTGTGACCGCCTGGGCCCTGGCATGGCCGACATA
TGCAAGAACTATATCAGCCAGTATTCTGAAATTGCTATCCAGATGATGATGCACATGCAG
GATCAGCAACCCAAGGAGATCTGTGCGCTGGTTGGGTTCTGTGATGAGGTGAAAGAGATG
CCCATGCAGACTCTGGTCCCCGCCAAAGTGGCCTCCAAGAATGTCATCCCTGCCCTGGAA
CTGGTGGAGCCCATTAAGAAGCACGAGGTCCCAGCAAAGTCTGATGTTTACTGTGAGGTG
TGTGAATTCCTGGTGAAGGAGGTGACCAAGCTGATTGACAACAACAAGACTGAGAAAGAA
ATACTCGACGCTTTTGACAAAATGTGCTCGAAGCTGCCGAAGTCCCTGTCGGAAGAGTGC
CAGGAGGTGGTGGACACGTACGGCAGCTCCATCCTGTCCATCCTGCTGGAGGAGGTCAGC
CCTGAGCTGGTGTGCAGCATGCTGCACCTCTGCTCTGGCACGCGGCTGCCTGCACTGACC
GTTCACGTGACTCAGCCAAAGGACGGTGGCTTCTGCGAAGTGTGCAAGAAGCTGGTGGGT
TATTTGGATCGCAACCTGGAGAAAAACAGCACCAAGCAGGAGATCCTGGCTGCTCTTGAG
AAAGGCTGCAGCTTCCTGCCAGACCCTTACCAGAAGCAGTGTGATCAGTTTGTGGCAGAG
TACGAGCCCGTGCTGATCGAGATCCTGGTGGAGGTGATGGATCCTTCCTTCGTGTGCTTG
AAAATTGGAGCCTGCCCCTCGGCCCATAAGCCCTTGTTGGGAACTGAGAAGTGTATATGG
GGCCCAAGCTACTGGTGCCAGAACACAGAGACAGCAGCCCAGTGCAATGCTGTCGAGCAT
TGCAAACGCCATGTGTGGAACTAG

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
D00422

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_8_Locus:
10q21-q22

# Macromolecular_Interacting_Partner_8_SNPs:
rs2070188; rs7869; rs1055754; rs2394846; rs762571; rs1015193; rs4237331; rs720295; rs7899959; rs7905774; rs7922255; rs885828; rs4237332; rs4747202; rs4747206; rs2070968; rs2394845; rs4747207; rs1900498; rs7350390; rs728289; rs2394844; rs6480560; rs9663508; rs2593163; rs749823; rs3747860; rs6480561; rs3819341; rs6480559; rs11000017; rs10740391; rs727414; rs2249814; rs2121535; rs7912803; rs2854986; rs7093252; rs10823852; rs3747855; rs11000020; rs16929408; rs11598989; rs11596365; rs4747203; rs12413995; rs10762483; rs4747204; rs4747208; rs11000016; rs12414356; rs2854992; rs11000025; rs727415; rs4747205; rs2166630; rs16913438; rs10762484; rs2854987; rs1900499; rs4454640; rs7917605; rs11000018; rs12413014; rs4746095; rs10762482; rs12415202; rs762573; rs12769743; rs1811087; rs2290023; rs7918049; rs11813373; rs9665661; rs11592448; rs9415055; rs11591470; rs7916568; rs7917015; rs11818931; rs2394843; rs11000019; rs4747209; rs7898293; rs4747210; rs11598617; rs9299509; rs9299510; rs12261323; rs1803650; rs11555015; rs11555016; rs11555021; rs11555017; rs1049882; rs1056711; rs1054851; rs1054293; rs11555018; rs41282246; rs11555020; rs36076120; rs14595; rs1053333; rs12844; rs28365839; rs1803651; rs2121536; rs7090110; rs11596605; rs35320964; rs34332602; rs2593164; rs11000024; rs7091271; rs9416009; rs2854984; rs5786051; rs34551152; rs11415214; rs2593162; rs5786050; rs959189; rs7898921; rs1894270; rs8181334; rs7477139; rs35814383; rs36035697; rs11595017; rs1867981; rs12266725; rs9416010; rs7072424; rs2854990; rs7098225; rs11277133; rs35027678; rs12220614; rs5786049; rs11000023; rs28535035; rs12571681; rs35131935; rs12247334; rs34701833; rs9415054; rs12782637; rs12252719; rs41307569; rs7922360; rs2854989; rs7911004; rs11285654; rs3061818; rs2593161; rs11000026; rs2854985; rs2854991; rs11305283; rs7899796; rs34761785; rs7072021; rs11000021; rs12247599; rs2854988; rs7076038; rs5007340; rs10566090; rs2305203; rs41306532; rs3891337; rs762572; rs5007339; rs10566091; rs2593160; rs3878001; rs35837949; rs7068078; rs35439306; rs12217799; rs35407936; rs34509443; rs35534537; rs2121537; rs35068924; rs11598625; rs34150455; rs28365838; rs7897854; rs34228343; rs10390; rs1054635; rs10762485; rs11000030; rs12252818; rs12416292; rs12774485; rs13377076; rs16929375; rs16929427; rs1867978; rs1992823; rs2290021; rs2290022; rs2394840; rs3802707; rs4746097; rs4747197; rs4747198; rs4747199; rs6480562; rs7085713; rs7092990; rs9415051; rs9415053

# Macromolecular_Interacting_Partner_8_General_References:
2515150; 2498298; 2842863; 1612590; 8323276; 1958198; 2013321; 2717620; 8370464; 2825202; 2868718; 3242555; 2209618; 3442600; 2845979; 3048308; 10562467; 7730378; 11180632; 10406958; 12510003; 10510427; 12518053; 7866401; 2302219; 2320574; 2019586; 2060627

# Macromolecular_Interacting_Partner_8_References:
12126932; 1350885; 2498298; 3048308

# Macromolecular_Interacting_Partner_9_ID:
7614

# Macromolecular_Interacting_Partner_9_Name:
P-selectin precursor

# Macromolecular_Interacting_Partner_9_Synonyms:
Granule membrane protein 140; GMP-140; PADGEM; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; CD62P antigen

# Macromolecular_Interacting_Partner_9_Gene_Name:
SELP

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Pselectin precursor
MANCQIAILYQRFQRVVFGISQLLCFSALISELTNQKEVAAWTYHYSTKAYSWNISRKYC
QNRYTDLVAIQNKNEIDYLNKVLPYYSSYYWIGIRKNNKTWTWVGTKKALTNEAENWADN
EPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHALCYTASCQDMSCSKQGECLETIGN
YTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPS
KLECLASGIWTNKPPQCLAAQCPPLKIPERGNMICLHSAKAFQHQSSCSFSCEEGFALVG
PEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRV
RGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGF
MLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNE
GLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFIC
DEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHF
SCNNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGLQCPALTTPGQGTMYCRHHPG
TFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNL
WGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEALTYFGGAVA
STIGLIMGGTLLALLRKRFRQKDDGKCPLNPHSHLGTYGVFTNAAFDPSP

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
830

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
90845

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
6.64

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  cellular process
Process:  cell adhesion
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00008:EGF;
PF00059:Lectin_C;
PF00084:Sushi

# Macromolecular_Interacting_Partner_9_Signals:
None

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
772-795

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
183389

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
LYAM3_HUMAN (P16109)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
SELP

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
SELP

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:10721

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>2493 bp
ATGGCCAACTGCCAAATAGCCATCTTGTACCAGAGATTCCAGAGAGTGGTCTTTGGAATT
TCCCAACTCCTTTGCTTCAGTGCCCTGATCTCTGAACTAACAAACCAGAAAGAAGTGGCA
GCATGGACTTATCATTACAGCACAAAAGCATACTCATGGAATATTTCCCGTAAATACTGC
CAGAATCGCTACACAGACTTAGTGGCCATCCAGAATAAAAATGAAATTGATTACCTCAAT
AAGGTCCTACCCTACTACAGCTCCTACTACTGGATTGGGATCCGAAAGAACAATAAGACA
TGGACATGGGTGGGAACCAAAAAGGCTCTCACCAACGAGGCTGAGAACTGGGCTGATAAT
GAACCTAACAACAAAAGGAACAACGAGGACTGCGTGGAGATATACATCAAGAGTCCGTCA
GCCCCTGGCAAGTGGAATGATGAGCACTGCTTGAAGAAAAAGCACGCATTGTGTTACACA
GCCTCCTGCCAGGACATGTCCTGCAGCAAACAAGGAGAGTGCCTCGAGACCATCGGGAAC
TACACCTGCTCCTGTTACCCTGGATTCTATGGGCCAGAATGTGAATACGTGAGAGAGTGT
GGAGAACTTGAGCTCCCTCAACACGTGCTCATGAACTGCAGCCACCCTCTGGGAAACTTC
TCTTTTAACTCGCAGTGCAGCTTCCACTGCACTGACGGGTACCAAGTAAATGGGCCCAGC
AAGCTGGAATGCTTGGCTTCTGGAATCTGGACAAATAAGCCTCCACAGTGTTTAGCTGCC
CAGTGCCCACCCCTGAAGATTCCTGAACGAGGAAACATGATCTGCCTTCATTCTGCAAAA
GCATTCCAGCATCAGTCTAGCTGCAGCTTCAGTTGTGAAGAGGGATTTGCATTAGTTGGA
CCGGAAGTGGTGCAATGCACAGCCTCGGGGGTATGGACAGCCCCAGCCCCAGTGTGTAAA
GCTGTGCAGTGTCAGCACCTGGAAGCCCCCAGTGAAGGAACCATGGACTGTGTTCATCCG
CTCACTGCTTTTGCCTATGGCTCCAGCTGCAAATTTGAGTGCCAGCCCGGCTACAGAGTG
AGGGGCTTGGACATGCTCCGCTGCATTGACTCTGGACACTGGTCTGCACCCTTGCCAACC
TGTGAGGCTATTTCGTGTGAGCCGCTGGAGAGTCCTGTCCACGGAAGCATGGATTGCTCT
CCATCCTTGAGAGCGTTTCAGTATGACACCAACTGTAGCTTCCGCTGTGCTGAAGGTTTC
ATGCTGAGAGGAGCCGATATAGTTCGGTGTGATAACTTGGGACAGTGGACAGCACCAGCC
CCAGTCTGTCAAGCTTTGCAGTGCCAGGATCTCCCAGTTCCAAATGAGGCCCGGGTGAAC
TGCTCCCACCCCTTCGGTGCCTTTAGGTACCAGTCAGTCTGCAGCTTCACCTGCAATGAA
GGCTTGCTCCTGGTGGGAGCAAGTGTGCTACAGTGCTTGGCTACTGGAAACTGGAATTCT
GTTCCTCCAGAATGCCAAGCCATTCCCTGCACACCTTTGCTAAGCCCTCAGAATGGAACA
ATGACCTGTGTTCAACCTCTTGGAAGTTCCAGTTATAAATCCACATGTCAATTCATCTGT
GACGAGGGATATTCTTTGTCTGGACCAGAAAGATTGGATTGTACTCGATCGGGACGCTGG
ACAGACTCCCCACCAATGTGTGAAGCCATCAAGTGCCCAGAACTCTTTGCCCCAGAGCAG
GGCAGCCTGGATTGTTCTGACACTCGTGGAGAATTCAATGTTGGCTCCACCTGTCATTTC
TCTTGTAACAATGGCTTTAAGCTGGAGGGGCCCAATAATGTGGAATGCACAACTTCTGGA
AGATGGTCAGCTACTCCACCAACCTGCAAAGGCATAGCATCACTTCCTACTCCAGGGTTG
CAATGTCCAGCCCTCACCACTCCTGGGCAGGGAACCATGTACTGTAGGCATCATCCGGGA
ACCTTTGGTTTTAATACCACTTGTTACTTTGGCTGCAACGCTGGATTCACACTCATAGGA
GACAGCACTCTCAGCTGCAGACCTTCAGGACAATGGACAGCAGTAACTCCAGCATGCAGA
GCTGTGAAATGCTCAGAACTACATGTTAATAAGCCAATAGCGATGAACTGCTCCAACCTC
TGGGGAAACTTCAGTTATGGATCAATCTGCTCTTTCCATTGTCTAGAGGGCCAGTTACTT
AATGGCTCTGCACAAACAGCATGCCAAGAGAATGGCCACTGGTCAACTACCGTGCCAACC
TGCCAAGCAGGACCATTGACTATCCAGGAAGCCCTGACTTACTTTGGTGGAGCGGTGGCT
TCTACAATAGGTCTGATAATGGGTGGGACGCTCCTGGCTTTGCTAAGAAAGCGTTTCAGA
CAAAAAGATGATGGGAAATGCCCCTTGAATCCTCACAGCCACCTAGGAACATATGGAGTT
TTTACAAACGCTGCATTTGACCCGAGTCCTTAA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
M60234

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_9_Locus:
1q22-q25

# Macromolecular_Interacting_Partner_9_SNPs:
rs6136; rs2228672; rs3917724; rs6125; rs6127; rs6133; rs3917769; rs6131; rs3917812; rs3917814; rs6130; rs6128; rs3917831; rs12042120; rs6135; rs6132; rs3917805; rs3917813; rs6129; rs3917853; rs3917854; rs3917856; rs3917855; rs3917852; rs2235302; rs2142760; rs2236868; rs2223303; rs742126; rs2244529; rs2235305; rs3917765; rs3917779; rs3917820; rs3917786; rs2236867; rs3917824; rs3917795; rs2205896; rs3917768; rs1569471; rs3917783; rs732314; rs2420378; rs3917688; rs3917679; rs3917843; rs760694; rs3917802; rs3917672; rs3917698; rs3917740; rs3917792; rs3766126; rs742125; rs3917782; rs3917797; rs3917819; rs2205895; rs2076074; rs3917832; rs742127; rs3917788; rs3917770; rs3917687; rs3917826; rs3917691; rs3917703; rs3917751; rs3917711; rs3917707; rs3917793; rs764199; rs3917806; rs3917798; rs3917683; rs3917655; rs3917739; rs3917803; rs3917750; rs3917811; rs3917848; rs3917836; rs3917729; rs3917657; rs2235304; rs3917743; rs3917781; rs3917790; rs3917715; rs2298903; rs3917762; rs3917775; rs3917727; rs3917778; rs3917678; rs3917686; rs3917690; rs3917710; rs3917835; rs3917789; rs3917862; rs3917787; rs3917730; rs3917771; rs3917780; rs3917661; rs3917827; rs3917705; rs3917844; rs3917709; rs3917753; rs3917839; rs3917720; rs3917717; rs3917851; rs2244526; rs2235303; rs3917731; rs3766122; rs3917714; rs1997664; rs17522707; rs3917810; rs3917849; rs3917777; rs3917840; rs2236866; rs3917744; rs10800459; rs3917816; rs3917829; rs3917664; rs3917699; rs3917726; rs3917748; rs3917754; rs3917845; rs3917807; rs3917675; rs3917697; rs3917772; rs3917870; rs3917818; rs3917767; rs3917732; rs3917713; rs3917659; rs3917721; rs3917660; rs3917773; rs3917825; rs3917866; rs3917873; rs3917841; rs3917681; rs3917706; rs3917662; rs12067152; rs3917693; rs1883247; rs3917838; rs3917822; rs3917850; rs3917695; rs3917859; rs3917701; rs3917734; rs2205894; rs3917842; rs3917745; rs3917725; rs3917801; rs3917704; rs3917808; rs3917665; rs3917828; rs3917684; rs3917737; rs3917696; rs3917676; rs3917682; rs3917654; rs3917830; rs3917846; rs3917833; rs3917794; rs3917785; rs3917774; rs3917752; rs3917708; rs13306837; rs3917784; rs3917689; rs3917680; rs3917865; rs3216192; rs3917761; rs3917847; rs3917804; rs3917694; rs3917716; rs3917719; rs3917733; rs3917747; rs3917728; rs3917692; rs3917834; rs2205893; rs3917702; rs3917763; rs3917749; rs3917700; rs3917663; rs3917758; rs3917722; rs1018828; rs1800805; rs1800808; rs3753306; rs742124; rs3917651; rs3917647; rs3917857; rs3917652; rs3917815; rs3917718; rs6134; rs7529463; rs35392020; rs6124; rs3917742; rs3917869; rs35101476; rs6126; rs3917875; rs3917872; rs34136141; rs35706397; rs3981193; rs35459911; rs5778626; rs3917809; rs9787264; rs3917756; rs3917764; rs6660207; rs3917868; rs3917677; rs3917666; rs34459258; rs3917863; rs3917746; rs3917669; rs3917685; rs3917800; rs35824243; rs10603647; rs3917674; rs3035296; rs12746584; rs3917741; rs1569478; rs13306840; rs11388284; rs6663860; rs3917757; rs35332999; rs5778625; rs3216191; rs3917723; rs3917670; rs3917871; rs35975478; rs3917861; rs3917735; rs34262091; rs3917667; rs9970173; rs3917668; rs10697644; rs3917867; rs3917821; rs3917766; rs34328397; rs3917817; rs12741092; rs3981194; rs34478968; rs34013258; rs11424563; rs35999435; rs35303442; rs3917837; rs3886553; rs3917864; rs35889765; rs3917658; rs35043289; rs3917712; rs3917759; rs10919199; rs3830734; rs11423543; rs35481060; rs34089819; rs12022109; rs3917760; rs35956562; rs13306836; rs13306841; rs3917738; rs3917799; rs3917656; rs12144431; rs3917673; rs3917776; rs1569477; rs3917796; rs36114270; rs2298904; rs12760008; rs3917874; rs3917860; rs3917823; rs11364443; rs3917755; rs12742506; rs12144433; rs7532184; rs3917671; rs3917791; rs3917653; rs28503394; rs36058464; rs1800806; rs35257922; rs3917650; rs3917648; rs10489184; rs10489185; rs10800460; rs10919197; rs12025263; rs12091166; rs12401978; rs1569476; rs16862404; rs17523783; rs2205892; rs2269648; rs3753305; rs3917858; rs6028; rs6664922; rs6666554; rs6691334; rs6703865; rs9332479; rs9332480; rs9332482; rs9332483; rs9332484; rs9332485; rs9332486; rs9332487; rs9332488; rs9332491; rs9332492; rs9332493; rs9332494; rs9332496; rs9332498; rs9332499; rs9332502; rs9332504; rs9332679; rs9332682; rs9332684; rs9659257

# Macromolecular_Interacting_Partner_9_General_References:
2466574; 7684381; 11237770; 8901515; 7505680; 9668170; 10391209

# Macromolecular_Interacting_Partner_9_References:
10619362; 10864479; 11479151; 11739312

# Macromolecular_Interacting_Partner_10_ID:
7803

# Macromolecular_Interacting_Partner_10_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_10_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_10_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_10_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_10_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_10_Signals:
None

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_10_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_10_SNPs:
Not Available

# Macromolecular_Interacting_Partner_10_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_10_References:
2986554; 43899; 6273571

# Macromolecular_Interacting_Partner_11_ID:
8432

# Macromolecular_Interacting_Partner_11_Name:
Complement C3 precursor [Contains: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Com

# Macromolecular_Interacting_Partner_11_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_11_Gene_Name:
C3

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Complement C3 precursor Contains: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2
MGPTSGPSLLLLLLTHLPLALGSPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVH
DFPGKKLVLSSEKTVLTPATNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKV
VLVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSL
SSQNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTE
KFYYIYNEKGLEVTITARFLYGKKVEGTAFVIFGIQDGEQRISLPESLKRIPIEDGSGEV
VLSRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQIHFTKT
PKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPL
SITVRTKKQELSEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLRMD
RAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPSFRLVAYYTLIGA
SGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDK
GVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAEL
QCPQPAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTRFISLGEAC
KKVFLDCCNYITELRRQHARASHLGLARSNLDEDIIAEENIVSRSEFPESWLWNVEDLKE
PPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFIDLRLPYSVV
RNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVI
VPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKE
DIPPADLSDQVPDTESETRILLQGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTP
TVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKRAPSTWLTA
YVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKD
MALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMG
RLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPVVRWLNEQR
YYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLR
SEETKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDA
KNTMILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSD
RNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDG
KLNKLCRDELCRCAEENCFIQKSDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDE
YIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGLSSDFWGEKPNLSY
IIGKDTWVEHWPEEDECQDEENQKQCQDLGAFTESMVVFGCPN

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
1663

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
187150

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
6.34

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  protease inhibitor activity
Function:  endopeptidase inhibitor activity
 ||
>>>
Process:  humoral immune response
Process:  complement activation
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
Process:  inflammatory response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_11_General_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Specific_Function:
Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF00207:A2M;
PF07678:A2M_comp;
PF01835:A2M_N;
PF07703:A2M_N_2;
PF07677:A2M_recep;
PF01821:ANATO;
PF01759:NTR

# Macromolecular_Interacting_Partner_11_Signals:
1-22

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
179665

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
CO3_HUMAN (P01024)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
C3

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
C3

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:1318

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>4992 bp
ATGGGACCCACCTCAGGTCCCAGCCTGCTGCTCCTGCTACTAACCCACCTCCCCCTGGCT
CTGGGGAGTCCCATGTACTCTATCATCACCCCCAACATCTTGCGGCTGGAGAGCGAGGAG
ACCATGGTGCTGGAGGCCCACGACGCGCAAGGGGATGTTCCAGTCACTGTTACTGTCCAC
GACTTCCCAGGCAAAAAACTAGTGCTGTCCAGTGAGAAGACTGTGCTGACCCCTGCCACC
AACCACATGGGCAACGTCACCTTCACGATCCCAGCCAACAGGGAGTTCAAGTCAGAAAAG
GGGCGCAACAAGTTCGTGACCGTGCAGGCCACCTTCGGGACCCAAGTGGTGGAGAAGGTG
GTGCTGGTCAGCCTGCAGAGCGGGTACCTCTTCATCCAGACAGACAAGACCATCTACACC
CCTGGCTCCACAGTTCTCTATCGGATCTTCACCGTCAACCACAAGCTGCTACCCGTGGGC
CGGACGGTCATGGTCAACATTGAGAACCCGGAAGGCATCCCGGTCAAGCAGGACTCCTTG
TCTTCTCAGAACCAGCTTGGCGTCTTGCCCTTGTCTTGGGACATTCCGGAACTCGTCAAC
ATGGGCCAGTGGAAGATCCGAGCCTACTATGAAAACTCACCACAGCAGGTCTTCTCCACT
GAGTTTGAGGTGAAGGAGTACGTGCTGCCCAGTTTCGAGGTCATAGTGGAGCCTACAGAG
AAATTCTACTACATCTATAACGAGAAGGGCCTGGAGGTCACCATCACCGCCAGGTTCCTC
TACGGGAAGAAAGTGGAGGGAACTGCCTTTGTCATCTTCGGGATCCAGGATGGCGAACAG
AGGATTTCCCTGCCTGAATCCCTCAAGCGCATTCCGATTGAGGATGGCTCGGGGGAGGTT
GTGCTGAGCCGGAAGGTACTGCTGGACGGGGTGCAGAACCTCCGAGCAGAAGACCTGGTG
GGGAAGTCTTTGTACGTGTCTGCCACCGTCATCTTGCACTCAGGCAGTGACATGGTGCAG
GCAGAGCGCAGCGGGATCCCCATCGTGACCTCTCCCTACCAGATCCACTTCACCAAGACA
CCCAAGTACTTCAAACCAGGAATGCCCTTTGACCTCATGGTGTTCGTGACGAACCCTGAT
GGCTCTCCAGCCTACCGAGTCCCCGTGGCAGTCCAGGGCGAGGACACTGTGCAGTCTCTA
ACCCAGGGAGATGGCGTGGCCAAACTCAGCATCAACACACACCCCAGCCAGAAGCCCTTG
AGCATCACGGTGCGCACGAAGAAGCAGGAGCTCTCGGAGGCAGAGCAGGCTACCAGGACC
ATGCAGGCTCTGCCCTACAGCACCGTGGGCAACTCCAACAATTACCTGCATCTCTCAGTG
CTACGTACAGAGCTCAGACCCGGGGAGACCCTCAACGTCAACTTCCTCCTGCGAATGGAC
CGCGCCCACGAGGCCAAGATCCGCTACTACACCTACCTGATCATGAACAAGGGCAGGCTG
TTGAAGGCGGGACGCCAGGTGCGAGAGCCCGGCCAGGACCTGGTGGTGCTGCCCCTGTCC
ATCACCACCGACTTCATCCCTTCCTTCCGCCTGGTGGCGTACTACACGCTGATCGGTGCC
AGCGGCCAGAGGGAGGTGGTGGCCGACTCCGTGTGGGTGGACGTCAAGGACTCCTGCGTG
GGCTCGCTGGTGGTAAAAAGCGGCCAGTCAGAAGACCGGCAGCCTGTACCTGGGCAGCAG
ATGACCCTGAAGATAGAGGGTGACCACGGGGCCCGGGTGGTACTGGTGGCCGTGGACAAG
GGCGTGTTCGTGCTGAATAAGAAGAACAAACTGACGCAGAGTAAGATCTGGGACGTGGTG
GAGAAGGCAGACATCGGCTGCACCCCGGGCAGTGGGAAGGATTACGCCGGTGTCTTCTCC
GACGCAGGGCTGACCTTCACGAGCAGCAGTGGCCAGCAGACCGCCCAGAGGGCAGAACTT
CAGTGCCCGCAGCCAGCCGCCCGCCGACGCCGTTCCGTGCAGCTCACGGAGAAGCGAATG
GACAAAGTCGGCAAGTACCCCAAGGAGCTGCGCAAGTGCTGCGAGGACGGCATGCGGGAG
AACCCCATGAGGTTCTCGTGCCAGCGCCGGACCCGTTTCATCTCCCTGGGCGAGGCGTGC
AAGAAGGTCTTCCTGGACTGCTGCAACTACATCACAGAGCTGCGGCGGCAGCACGCGCGG
GCCAGCCACCTGGGCCTGGCCAGGAGTAACCTGGATGAGGACATCATTGCAGAAGAGAAC
ATCGTTTCCCGAAGTGAGTTCCCAGAGAGCTGGCTGTGGAACGTTGAGGACTTGAAAGAG
CCACCGAAAAATGGAATCTCTACGAAGCTCATGAATATATTTTTGAAAGACTCCATCACC
ACGTGGGAGATTCTGGCTGTCAGCATGTCGGACAAGAAAGGGATCTGTGTGGCAGACCCC
TTCGAGGTCACAGTAATGCAGGACTTCTTCATCGACCTGCGGCTACCCTACTCTGTTGTT
CGAAACGAGCAGGTGGAAATCCGAGCCGTTCTCTACAATTACCGGCAGAACCAAGAGCTC
AAGGTGAGGGTGGAACTACTCCACAATCCAGCCTTCTGCAGCCTGGCCACCACCAAGAGG
CGTCACCAGCAGACCGTAACCATCCCCCCCAAGTCCTCGTTGTCCGTTCCATATGTCATC
GTGCCGCTAAAGACCGGCCTGCAGGAAGTGGAAGTCAAGGCTGCCGTCTACCATCATTTC
ATCAGTGACGGTGTCAGGAAGTCCCTGAAGGTCGTGCCGGAAGGAATCAGAATGAACAAA
ACTGTGGCTGTTCGCACCCTGGATCCAGAACGCCTGGGCCGTGAAGGAGTGCAGAAAGAG
GACATCCCACCTGCAGACCTCAGTGACCAAGTCCCGGACACCGAGTCTGAGACCAGAATT
CTCCTGCAAGGGACCCCAGTGGCCCAGATGACAGAGGATGCCGTCGACGCGGAACGGCTG
AAGCACCTCATTGTGACCCCCTCGGGCTGCGGGGAACAGAACATGATCGGCATGACGCCC
ACGGTCATCGCTGTGCATTACCTGGATGAAACGGAGCAGTGGGAGAAGTTCGGCCTAGAG
AAGCGGCAGGGGGCCTTGGAGCTCATCAAGAAGGGGTACACCCAGCAGCTGGCCTTCAGA
CAACCCAGCTCTGCCTTTGCGGCCTTCGTGAAACGGGCACCCAGCACCTGGCTGACCGCC
TACGTGGTCAAGGTCTTCTCTCTGGCTGTCAACCTCATCGCCATCGACTCCCAAGTCCTC
TGCGGGGCTGTTAAATGGCTGATCCTGGAGAAGCAGAAGCCCGACGGGGTCTTCCAGGAG
GATGCGCCCGTGATACACCAAGAAATGATTGGTGGATTACGGAACAACAACGAGAAAGAC
ATGGCCCTCACGGCCTTTGTTCTCATCTCGCTGCAGGAGGCTAAAGATATTTGCGAGGAG
CAGGTCAACAGCCTGCCAGGCAGCATCACTAAAGCAGGAGACTTCCTTGAAGCCAACTAC
ATGAACCTACAGAGATCCTACACTGTGGCCATTGCTGGCTATGCTCTGGCCCAGATGGGC
AGGCTGAAGGGGCCTCTTCTTAACAAATTTCTGACCACAGCCAAAGATAAGAACCGCTGG
GAGGACCCTGGTAAGCAGCTCTACAACGTGGAGGCCACATCCTATGCCCTCTTGGCCCTA
CTGCAGCTAAAAGACTTTGACTTTGTGCCTCCCGTCGTGCGTTGGCTCAATGAACAGAGA
TACTACGGTGGTGGCTATGGCTCTACCCAGGCCACCTTCATGGTGTTCCAAGCCTTGGCT
CAATACCAAAAGGACGCCCCTGACCACCAGGAACTGAACCTTGATGTGTCCCTCCAACTG
CCCAGCCGCAGCTCCAAGATCACCCACCGTATCCACTGGGAATCTGCCAGCCTCCTGCGA
TCAGAAGAGACCAAGGAAAATGAGGGTTTCACAGTCACAGCTGAAGGAAAAGGCCAAGGC
ACCTTGTCGGTGGTGACAATGTACCATGCTAAGGCCAAAGATCAACTCACCTGTAATAAA
TTCGACCTCAAGGTCACCATAAAACCAGCACCGGAAACAGAAAAGAGGCCTCAGGATGCC
AAGAACACTATGATCCTTGAGATCTGTACCAGGTACCGGGGAGACCAGGATGCCACTATG
TCTATATTGGACATATCCATGATGACTGGCTTTGCTCCAGACACAGATGACCTGAAGCAG
CTGGCCAATGGTGTTGACAGATACATCTCCAAGTATGAGCTGGACAAAGCCTTCTCCGAT
AGGAACACCCTCATCATCTACCTGGACAAGGTCTCACACTCTGAGGATGACTGTCTAGCT
TTCAAAGTTCACCAATACTTTAATGTAGAGCTTATCCAGCCTGGAGCAGTCAAGGTCTAC
GCCTATTACAACCTGGAGGAAAGCTGTACCCGGTTCTACCATCCGGAAAAGGAGGATGGA
AAGCTGAACAAGCTCTGCCGTGATGAACTGTGCCGCTGTGCTGAGGAGAATTGCTTCATA
CAAAAGTCGGATGACAAGGTCACCCTGGAAGAACGGCTGGACAAGGCCTGTGAGCCAGGA
GTGGACTATGTGTACAAGACCCGACTGGTCAAGGTTCAGCTGTCCAATGACTTTGACGAG
TACATCATGGCCATTGAGCAGACCATCAAGTCAGGCTCGGATGAGGTGCAGGTTGGACAG
CAGCGCACGTTCATCAGCCCCATCAAGTGCAGAGAAGCCCTGAAGCTGGAGGAGAAGAAA
CACTACCTCATGTGGGGTCTCTCCTCCGATTTCTGGGGAGAGAAGCCCAACCTCAGCTAC
ATCATCGGGAAGGACACTTGGGTGGAGCACTGGCCTGAGGAGGACGAATGCCAAGACGAA
GAGAACCAGAAACAATGCCAGGACCTCGGCGCCTTCACCGAGAGCATGGTTGTCTTTGGG
TGCCCCAACTGA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
K02765

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_11_Locus:
19p13.3-p13.2

# Macromolecular_Interacting_Partner_11_SNPs:
rs2230199; rs11569422; rs1047286; rs11569534; rs11569541; rs2230210; rs428453; rs423490; rs344534; rs2230205; rs2230200; rs2230208; rs7951; rs2230204; rs2230203; rs11569453; rs2230201; rs11569535; rs34029609; rs17030; rs11569571; rs339394; rs432001; rs2241392; rs344548; rs1389623; rs6417195; rs344539; rs8107911; rs2253756; rs2277984; rs406514; rs8112351; rs421147; rs451760; rs2287846; rs2287847; rs1895388; rs344550; rs8108377; rs7257062; rs403897; rs438703; rs430507; rs2547438; rs594974; rs2250656; rs344543; rs400443; rs388442; rs436041; rs10402876; rs1389625; rs7258241; rs10410674; rs389404; rs366510; rs11085193; rs2287845; rs11672613; rs2241389; rs344540; rs2241394; rs431543; rs420088; rs435499; rs2642196; rs10406463; rs2270521; rs2355315; rs11569438; rs11569507; rs11569523; rs10221476; rs2642208; rs11569429; rs433594; rs344549; rs344536; rs11569428; rs11569562; rs344538; rs2241390; rs11569536; rs11085196; rs448260; rs3745567; rs344555; rs11085194; rs2355314; rs11569411; rs11569511; rs11569458; rs344542; rs344552; rs10403713; rs11569556; rs11569565; rs445750; rs11085192; rs11085199; rs4807894; rs10411506; rs3745565; rs2642207; rs11569538; rs11569529; rs392690; rs2241391; rs10414623; rs11569457; rs10411974; rs406114; rs2270520; rs11569441; rs11569501; rs408290; rs2241393; rs2547436; rs432823; rs385791; rs11569459; rs344535; rs3215059; rs448488; rs11085195; rs344541; rs237554; rs408114; rs2642209; rs344553; rs344554; rs11569582; rs9710242; rs2277983; rs11569561; rs2287848; rs12609788; rs3745568; rs3745566; rs344545; rs4807895; rs344546; rs451429; rs10853995; rs344537; rs11569514; rs402756; rs11666133; rs11569440; rs11569515; rs11569495; rs11569540; rs11569576; rs11569558; rs11569520; rs11569552; rs405566; rs11569425; rs344551; rs11569436; rs11569508; rs11569497; rs11569517; rs11569545; rs11569510; rs11570240; rs11569414; rs11569400; rs11569542; rs2642203; rs11569519; rs11569500; rs11569474; rs11569499; rs445954; rs11569572; rs11882156; rs189367; rs11569433; rs11569470; rs11569416; rs11569547; rs11569575; rs12609787; rs11569439; rs11569492; rs11569502; rs11570241; rs11569446; rs11570239; rs11569404; rs408004; rs11569413; rs11569494; rs344544; rs11569395; rs11569443; rs11569427; rs11569479; rs11569513; rs11569469; rs11569553; rs11569526; rs11569424; rs11569406; rs11569516; rs11569496; rs11569448; rs11569415; rs2642198; rs344556; rs11569518; rs11569509; rs11569551; rs2355316; rs11569521; rs11569560; rs11569397; rs11569573; rs11570243; rs11569544; rs11569417; rs11569491; rs11569512; rs11569503; rs11569445; rs11569432; rs11569450; rs11569546; rs11569537; rs11085197; rs11569431; rs11569557; rs11569426; rs11569401; rs393770; rs11569419; rs11569410; rs11569487; rs11569442; rs11569468; rs11569505; rs11569466; rs11569555; rs11569449; rs11569584; rs11569471; rs406414; rs11569564; rs11665922; rs163913; rs379527; rs10402399; rs11569393; rs4513211; rs2004270; rs339392; rs11569394; rs339393; rs11569585; rs11569587; rs17626094; rs7508623; rs1803222; rs34370481; rs1803220; rs1803225; rs11569472; rs7256789; rs1803224; rs1803223; rs1803219; rs34116775; rs12981071; rs2547440; rs35537718; rs2642206; rs5826946; rs11569435; rs12971981; rs35162257; rs344547; rs11569532; rs1833792; rs408744; rs11569570; rs11569405; rs2431865; rs12980813; rs11569581; rs2547439; rs34273347; rs11569548; rs35401128; rs11569578; rs11569396; rs182940; rs12981081; rs34769842; rs34081046; rs7248462; rs35743334; rs11569583; rs2277982; rs380819; rs11569398; rs11671205; rs427964; rs34420628; rs11569522; rs34248111; rs11569490; rs10572042; rs36168646; rs11569421; rs2642199; rs11421545; rs10537124; rs35530833; rs3837943; rs34871929; rs35726512; rs36180890; rs2431864; rs36160495; rs7408847; rs11569577; rs11570244; rs7248455; rs11569524; rs36032405; rs8102633; rs5017915; rs2642197; rs35405724; rs10628051; rs11569418; rs11569460; rs34917455; rs11569444; rs5826944; rs2355317; rs36014764; rs11569549; rs11569504; rs11569437; rs11569462; rs11569533; rs35553307; rs11569543; rs1389624; rs11569559; rs11883407; rs35927910; rs12982678; rs11569475; rs11569447; rs1065579; rs11569506; rs11569399; rs12980805; rs12974348; rs11569580; rs11569498; rs427593; rs10415542; rs11569579; rs33986916; rs8102618; rs11569489; rs10596077; rs2642202; rs10408682; rs34173957; rs10526582; rs35584057; rs12983602; rs34193524; rs34804877; rs10715405; rs16993725; rs10664581; rs10659507; rs374750; rs11666563; rs3745558; rs34659937; rs5017914; rs35034584; rs11569574; rs13345176; rs10628052; rs2291665; rs11569434; rs11569493; rs35028655; rs11569539; rs41500852; rs7252135; rs12971991; rs12609780; rs11569403; rs35473940; rs11569563; rs444056; rs11569569; rs7508631; rs12981329; rs11569586; rs35008633; rs28709832; rs34349609; rs11569567; rs34748637; rs413141; rs34208747; rs11569566; rs11569568; rs391757; rs28685640; rs10407174; rs7508533; rs2047138; rs2004271; rs446220; rs1077667; rs12981348; rs15234; rs171094; rs1862509; rs1862510; rs2291667; rs2291668; rs2642210; rs340126; rs344558; rs344614; rs344615; rs35263980; rs4082576; rs4490100; rs8112236

# Macromolecular_Interacting_Partner_11_General_References:
2579379; 1238393; 7539791; 6175959; 3279119; 1577777; 8416818; 12754519; 3260670; 9596584; 2473125; 2584723; 1976733; 7961791

# Macromolecular_Interacting_Partner_11_References:
7499866

# Macromolecular_Interacting_Partner_12_ID:
7886

# Macromolecular_Interacting_Partner_12_Name:
L-selectin precursor

# Macromolecular_Interacting_Partner_12_Synonyms:
Lymph node homing receptor; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; TQ1; gp90-MEL; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; CD62L antigen

# Macromolecular_Interacting_Partner_12_Gene_Name:
SELL

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Lselectin precursor
MIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDN
YTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPN
NKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTC
NCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETT
CGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKK
TICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKK
GKKSKRSMNDPY

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
372

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
42187

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
6.57

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  cellular process
Process:  cell adhesion
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
Cell surface adhesion protein. Mediate the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF00008:EGF;
PF00059:Lectin_C;
PF00084:Sushi

# Macromolecular_Interacting_Partner_12_Signals:
1-28

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
333-355

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
307134

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
LYAM1_HUMAN (P14151)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
SELL

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
SELL

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:10720

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>1119 bp
ATGATATTTCCATGGAAATGTCAGAGCACCCAGAGGGACTTATGGAACATCTTCAAGTTG
TGGGGGTGGACAATGCTCTGTTGTGATTTCCTGGCACATCATGGAACCGACTGCTGGACT
TACCATTATTCTGAAAAACCCATGAACTGGCAAAGGGCTAGAAGATTCTGCCGAGACAAT
TACACAGATTTAGTTGCCATACAAAACAAGGCGGAAATTGAGTATCTGGAGAAGACTCTG
CCTTTCAGTCGTTCTTACTACTGGATAGGAATCCGGAAGATAGGAGGAATATGGACGTGG
GTGGGAACCAACAAATCTCTTACTGAAGAAGCAGAGAACTGGGGAGATGGTGAGCCCAAC
AACAAGAAGAACAAGGAGGACTGCGTGGAGATCTATATCAAGAGAAACAAAGATGCAGGC
AAATGGAACGATGACGCCTGCCACAAACTAAAGGCAGCCCTCTGTTACACAGCTTCTTGC
CAGCCCTGGTCATGCAGTGGCCATGGAGAATGTGTAGAAATCATCAATAATTACACCTGC
AACTGTGATGTGGGGTACTATGGGCCCCAGTGTCAGCTTGTGATTCAGTGTGAGCCTTTG
GAGGCCCCAGAGCTGGGTACCATGGACTGTACTCACCCTTTGGGAAACTTCAGCTTCAGC
TCACAGTGTGCCTTCAGCTGCTCTGAAGGAACAAACTTAACTGGGATTGAAGAAACCACC
TGTGGACCATTTGGAAACTGGTCATCTCCAGAACCAACCTGTCAAGTGATTCAGTGTGAG
CCTCTATCAGCACCAGATTTGGGGATCATGAACTGTAGCCATCCCCTGGCCAGCTTCAGC
TTTACCTCTGCATGTACCTTCATCTGCTCAGAAGGAACTGAGTTAATTGGGAAGAAGAAA
ACCATTTGTGAATCATCTGGAATCTGGTCAAATCCTAGTCCAATATGTCAAAAATTGGAC
AAAAGTTTCTCAATGATTAAGGAGGGTGATTATAACCCCCTCTTCATTCCAGTGGCAGTC
ATGGTTACTGCATTCTCTGGGTTGGCATTTATCATTTGGCTGGCAAGGAGATTAAAAAAA
GGCAAGAAATCCAAGAGAAGTATGAATGACCCATATTAA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
M25280

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_12_Locus:
1q23-q25

# Macromolecular_Interacting_Partner_12_SNPs:
rs3177980; rs4987382; rs4987310; rs1051091; rs4987286; rs4987279; rs4987394; rs909628; rs7553; rs12938; rs2205848; rs2223286; rs964556; rs1883228; rs2205847; rs4987373; rs7418242; rs4987353; rs2420381; rs4427452; rs4987367; rs964555; rs4987369; rs4987318; rs4987351; rs4987360; rs4987354; rs2298900; rs4656189; rs4987285; rs4987314; rs4987358; rs4987299; rs4987347; rs4987304; rs4987381; rs4987345; rs4987396; rs4987361; rs4987316; rs4987339; rs2298899; rs4140655; rs4987306; rs4987376; rs4987379; rs4987352; rs10919222; rs4987343; rs4987307; rs4987331; rs4987320; rs4987364; rs12072966; rs4987302; rs4987323; rs4987313; rs4987370; rs4987366; rs1883229; rs2298901; rs964557; rs4987284; rs4987400; rs4987317; rs4987281; rs1569457; rs4987325; rs12137905; rs3766129; rs4987328; rs4987278; rs4656697; rs4987395; rs4987338; rs4987301; rs4987292; rs4987363; rs4987322; rs4987342; rs4987275; rs4987340; rs12087033; rs4987315; rs4987324; rs2298902; rs4987287; rs4987403; rs4987368; rs4987337; rs4987291; rs4987276; rs4987404; rs12029669; rs4987319; rs4987273; rs4987327; rs4987293; rs4987280; rs4987341; rs4987397; rs4987282; rs4987372; rs4987346; rs4987300; rs4987380; rs4987298; rs4987297; rs4987375; rs4987277; rs4987303; rs4987355; rs4987359; rs4987326; rs4987321; rs4987350; rs4987308; rs4987305; rs4987311; rs4987283; rs4987332; rs4987288; rs17525350; rs4987333; rs4987362; rs4987296; rs4987399; rs4987330; rs4987357; rs4987349; rs4987371; rs4987377; rs12034295; rs4987391; rs4987389; rs2205849; rs4987384; rs4987388; rs4987270; rs4987265; rs4987268; rs4987266; rs4987393; rs4987272; rs4987267; rs4987386; rs4987271; rs4987309; rs13306835; rs12758669; rs4987383; rs4987406; rs41272473; rs6688874; rs11282890; rs4987356; rs4987289; rs35384355; rs6662759; rs35466992; rs4987334; rs4987378; rs34442887; rs33928184; rs35664690; rs4987295; rs4987329; rs12036937; rs4987348; rs4987336; rs4987401; rs4987274; rs10919223; rs4987402; rs4987374; rs4987290; rs4987344; rs4987312; rs6701685; rs12087116; rs35383673; rs4987405; rs13306834; rs34922988; rs4987294; rs4987398; rs12126331; rs35787847; rs34753824; rs10654815; rs28634201; rs35535713; rs4987365; rs12120772; rs4987335; rs11363811; rs13306833; rs4987408; rs6656492; rs12045667; rs4987269; rs4987410; rs4987385; rs4987407; rs6680979; rs12065232; rs3835455; rs4987409; rs4987390; rs4987392; rs4987387; rs12079552; rs35793047; rs12036888; rs12038193; rs12038568; rs12043338; rs12046180; rs12046209; rs12049148; rs12076368; rs12133642; rs12133666; rs12134971; rs12723862; rs12738302; rs12738329; rs12743104; rs17524608; rs2420504; rs34164630; rs4363475; rs4656698; rs4656699; rs4656700; rs4656701; rs4656703; rs6427212; rs6693963; rs7531464; rs7531806; rs7543304

# Macromolecular_Interacting_Partner_12_General_References:
2664786; 2473156; 2509939; 2663882; 1692315; 7488174

# Macromolecular_Interacting_Partner_12_References:
10644477; 10849115; 10914491; 11071858

# Macromolecular_Interacting_Partner_13_ID:
7905

# Macromolecular_Interacting_Partner_13_Name:
T-cell surface glycoprotein CD1e precursor

# Macromolecular_Interacting_Partner_13_Synonyms:
CD1e antigen; R2G1

# Macromolecular_Interacting_Partner_13_Gene_Name:
CD1E

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Tcell surface glycoprotein CD1e precursor
MLLLFLLFEGLCCPGENTAAAEEQLSFRMLQTSSFANHSWAHSEGSGWLGDLQTHGWDTV
LGTIRFLKPWSHGNFSKQELKNLQSLFQLYFHSFIQIVQASAGQFQLEYPFEIQILAGCR
MNAPQIFLNMAYQGSDFLSFQGISWEPSPGAGIRAQNICKVLNRYLDIKEILQSLLGHTC
PRFLAGLMEAGESELKRKVKPEAWLSCGPSPGPGRLQLVCHVSGFYPKPVWVMWMRGEQE
QRGTQRGDVLPNADETWYLRATLDVAAGEAAGLSCRVKHSSLGGHDLIIHWGGYSIFLIL
ICLTVIVTLVILVVVDSRLKKQ

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
322

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
35986

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
7.25

# Macromolecular_Interacting_Partner_13_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF07654:C1-set

# Macromolecular_Interacting_Partner_13_Signals:
1-19

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
295-315

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
296640

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
CD1E_HUMAN (P15812)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
CD1E

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
CD1E

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:1638

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>972 bp
ATGCTGCTCCTGTTCCTCCTCTTCGAGGGTCTCTGCTGTCCTGGGGAAAATACAGCAGCA
GCAGAGGAGCAGCTGTCCTTCCGCATGCTCCAAACTTCCTCCTTTGCCAACCACAGCTGG
GCACACAGTGAGGGCTCAGGATGGCTGGGTGACCTGCAGACTCATGGCTGGGACACTGTC
TTGGGCACCATCCGCTTTCTGAAGCCCTGGTCCCATGGAAACTTCAGCAAGCAGGAGCTG
AAAAACTTACAGTCACTGTTCCAGTTATACTTCCATAGTTTTATCCAGATAGTGCAAGCT
TCTGCTGGTCAATTTCAGCTTGAATACCCCTTCGAGATCCAGATATTAGCTGGCTGTAGA
ATGAATGCCCCACAAATCTTCTTAAATATGGCATATCAAGGGTCAGATTTCCTGAGTTTC
CAAGGAATTTCCTGGGAGCCATCTCCAGGAGCAGGGATCCGGGCCCAGAACATCTGTAAA
GTGCTCAATCGCTACCTAGATATTAAGGAAATACTGCAAAGCCTTCTTGGTCACACCTGC
CCTCGATTTCTAGCGGGGCTCATGGAAGCAGGGGAGTCAGAACTGAAACGGAAAGTGAAG
CCAGAGGCCTGGCTGTCCTGTGGCCCCAGTCCTGGCCCTGGCCGTCTGCAGCTTGTGTGC
CATGTCTCAGGATTCTACCCAAAGCCCGTGTGGGTGATGTGGATGCGGGGTGAGCAGGAG
CAGCGGGGCACTCAGCGAGGGGACGTCCTGCCTAATGCTGACGAGACATGGTATCTCCGA
GCAACCCTGGATGTGGCGGCTGGGGAGGCAGCTGGCCTGTCCTGTCGGGTGAAACACAGC
AGTCTAGGGGGCCATGATCTAATCATCCATTGGGGTGGATATTCCATCTTTCTCATCCTG
ATCTGTTTGACTGTGATAGTTACCCTGGTCATATTGGTTGTAGTTGACTCACGGTTAAAA
AAACAGAGGTGA

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
X14975

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_13_Locus:
1q22-q23

# Macromolecular_Interacting_Partner_13_SNPs:
rs1065457; rs2873587; rs16840106; rs11809955; rs11805538; rs11804812; rs858565; rs9729737; rs11809933; rs11806627; rs35079671; rs3180089; rs35116276; rs35736767; rs36041664; rs35965526; rs34913045; rs41273487; rs35184522; rs34393144; rs10908648; rs11264959; rs11264960; rs11264962; rs11264963; rs11581936; rs11584245; rs11586713; rs11588320; rs11799792; rs11807851; rs11808256; rs11809011; rs11809338; rs12023386; rs12038925; rs12084190; rs12139388; rs12726939; rs12736034; rs12742463; rs12754843; rs2106085; rs2106086; rs2157684; rs2317955; rs34460006; rs34633423; rs35752748; rs765629; rs858566

# Macromolecular_Interacting_Partner_13_General_References:
2467814; 10488738; 3097645; 11019917

# Macromolecular_Interacting_Partner_13_References:
11956292

# Macromolecular_Interacting_Partner_14_ID:
8289

# Macromolecular_Interacting_Partner_14_Name:
T-cell surface glycoprotein CD1d precursor

# Macromolecular_Interacting_Partner_14_Synonyms:
CD1d antigen; R3G1

# Macromolecular_Interacting_Partner_14_Gene_Name:
CD1D

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>Tcell surface glycoprotein CD1d precursor
MGCLLFLLLWALLQAWGSAEVPQRLFPLRCLQISSFANSSWTRTDGLAWLGELQTHSWSN
DSDTVRSLKPWSQGTFSDQQWETLQHIFRVYRSSFTRDVKEFAKMLRLSYPLELQVSAGC
EVHPGNASNNFFHVAFQGKDILSFQGTSWEPTQEAPLWVNLAIQVLNQDKWTRETVQWLL
NGTCPQFVSGLLESGKSELKKQVKPKAWLSRGPSPGPGRLLLVCHVSGFYPKPVWVKWMR
GEQEQQGTQPGDILPNADETWYLRATLDVVAGEAAGLSCRVKHSSLEGQDIVLYWGGSYT
SMGLIALAVLACLLFLLIVGFTSRFKRQTSYQGVL

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
335

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
37718

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
8.28

# Macromolecular_Interacting_Partner_14_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_14_General_Function:
Not Available

# Macromolecular_Interacting_Partner_14_Specific_Function:
Not known

# Macromolecular_Interacting_Partner_14_Pathway:
Not Available

# Macromolecular_Interacting_Partner_14_Reaction:
Not Available

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF07654:C1-set

# Macromolecular_Interacting_Partner_14_Signals:
1-19

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
302-322

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
619798

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
CD1D_HUMAN (P15813)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
CD1D

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
CD1D

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:1637

# Macromolecular_Interacting_Partner_14_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>1008 bp
ATGGGGTGCCTGCTGTTTCTGCTGCTCTGGGCGCTCCTCCAGGCTTGGGGAAGCGCTGAA
GTCCCGCAAAGGCTTTTCCCCCTCCGCTGCCTCCAGATCTCGTCCTTCGCCAATAGCAGC
TGGACGCGCACCGACGGCTTGGCGTGGCTGGGGGAGCTGCAGACGCACAGCTGGAGCAAC
GACTCGGACACCGTCCGCTCTCTGAAGCCTTGGTCCCAGGGCACGTTCAGCGACCAGCAG
TGGGAGACGCTGCAGCATATATTTCGGGTTTATCGAAGCAGCTTCACCAGGGACGTGAAG
GAATTCGCCAAAATGCTACGCTTATCCTATCCCTTGGAGCTCCAGGTGTCCGCTGGCTGT
GAGGTGCACCCTGGGAACGCCTCAAATAACTTCTTCCATGTAGCATTTCAAGGAAAAGAT
ATCCTGAGTTTCCAAGGAACTTCTTGGGAGCCAACCCAAGAGGCCCCACTTTGGGTAAAC
TTGGCCATTCAAGTGCTCAACCAGGACAAGTGGACGAGGGAAACAGTGCAGTGGCTCCTT
AATGGCACCTGCCCCCAATTTGTCAGTGGCCTCCTTGAGTCAGGGAAGTCGGAACTGAAG
AAGCAAGTGAAGCCCAAGGCCTGGCTGTCCCGTGGCCCCAGTCCTGGCCCTGGCCGTCTG
CTGCTGGTGTGCCATGTCTCAGGATTCTACCCAAAGCCTGTATGGGTGAAGTGGATGCGG
GGTGAGCAGGAGCAGCAGGGCACTCAGCCAGGGGACATCCTGCCCAATGCTGACGAGACA
TGGTATCTCCGAGCAACCCTGGATGTGGTGGCTGGGGAGGCAGCTGGCCTGTCCTGTCGG
GTGAAGCACAGCAGTCTAGAGGGCCAGGACATCGTCCTCTACTGGGGTGGGAGCTACACC
TCCATGGGCTTGATTGCCTTGGCAGTCCTGGCGTGCTTGCTGTTCCTCCTCATTGTGGGC
TTTACCTCCCGGTTTAAGAGGCAAACTTCCTATCAGGGCGTCCTGTGA

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
L38820

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_14_Locus:
1q22-q23

# Macromolecular_Interacting_Partner_14_SNPs:
rs859008; rs3754471; rs859010; rs859009; rs859015; rs426336; rs7524536; rs859011; rs859012; rs859013; rs692565; rs422236; rs11762; rs3754469; rs16839909; rs35388773; rs4369228; rs1565845; rs34984399; rs1624778; rs3021481; rs1324656; rs1617972; rs1617977; rs1618045; rs1618053; rs1619547; rs1633121; rs1633122; rs1633123; rs1690769; rs1690771; rs1690772; rs1690774; rs1748362; rs1748363; rs1748365; rs1748366; rs1748372; rs1748373; rs1748374; rs1748375; rs1980757; rs2023631; rs3021476; rs3021477; rs3021479; rs3021480; rs3021485; rs3021486; rs3087210; rs3087211; rs3087213; rs371380; rs3754472; rs385250; rs404362; rs420491; rs6671299; rs859003; rs859004; rs859005; rs859006; rs859007; rs973742; rs980937

# Macromolecular_Interacting_Partner_14_General_References:
2467814; 2463622; 10488738; 3097645

# Macromolecular_Interacting_Partner_14_References:
15051763; 16314439

# Macromolecular_Interacting_Partner_15_ID:
7923

# Macromolecular_Interacting_Partner_15_Name:
Galectin-3

# Macromolecular_Interacting_Partner_15_Synonyms:
Galactose-specific lectin 3; Mac-2 antigen; IgE-binding protein; 35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Laminin-binding protein; Lectin L-29; L-31; Galactoside-binding protein; GALBP

# Macromolecular_Interacting_Partner_15_Gene_Name:
LGALS3

# Macromolecular_Interacting_Partner_15_Protein_Sequence:
>Galectin3
MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPP
GAYHGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSAPGAYPATGPYGAPAGPLIVPYNL
PLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNN
WGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDI
DLTSASYTMI

# Macromolecular_Interacting_Partner_15_Number_of_Residues:
250

# Macromolecular_Interacting_Partner_15_Molecular_Weight:
26189

# Macromolecular_Interacting_Partner_15_Theoretical_pI:
8.82

# Macromolecular_Interacting_Partner_15_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_15_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_15_Specific_Function:
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration

# Macromolecular_Interacting_Partner_15_Pathway:
Not Available

# Macromolecular_Interacting_Partner_15_Reaction:
Not Available

# Macromolecular_Interacting_Partner_15_Pfam_Domain_Function:
PF00337:Gal-bind_lectin

# Macromolecular_Interacting_Partner_15_Signals:
None

# Macromolecular_Interacting_Partner_15_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_15_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_15_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_15_GenBank_ID_Protein:
179531

# Macromolecular_Interacting_Partner_15_SwissProt_ID:
LEG3_HUMAN (P17931)

# Macromolecular_Interacting_Partner_15_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_15_Genecard_id:
LGALS3

# Macromolecular_Interacting_Partner_15_Geneatlas_id:
LGALS3

# Macromolecular_Interacting_Partner_15_hgnc_id:
HGNC:6563

# Macromolecular_Interacting_Partner_15_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_15_Subcellular_Location:
Nucleus. Note=Cytoplasmic in adenomas and carcinomas. May be secreted by a non-classical secretory pathway and associate with the cell surface

# Macromolecular_Interacting_Partner_15_Gene_Sequence:
>753 bp
ATGGCAGACAATTTTTCGCTCCATGATGCGTTATCTGGGTCTGGAAACCCAAACCCTCAA
GGATGGCCTGGCGCATGGGGGAACCAGCCTGCTGGGGCAGGGGGCTACCCAGGGGCTTCC
TATCCTGGGGCCTACCCCGGGCAGGCACCCCCAGGGGCTTATCCTGGACAGGCACCTCCA
GGCGCCTACCATGGAGCACCTGGAGCTTATCCCGGAGCACCTGCACCTGGAGTCTACCCA
GGGCCACCCAGCGGCCCTGGGGCCTACCCATCTTCTGGACAGCCAAGTGCCCCCGGAGCC
TACCCTGCCACTGGCCCCTATGGCGCCCCTGCTGGGCCACTGATTGTGCCTTATAACCTG
CCTTTGCCTGGGGGAGTGGTGCCTCGCATGCTGATAACAATTCTGGGCACGGTGAAGCCC
AATGCAAACAGAATTGCTTTAGATTTCCAAAGAGGGAATGATGTTGCCTTCCACTTTAAC
CCACGCTTCAATGAGAACAACAGGAGAGTCATTGTTTGCAATACAAAGCTGGATAATAAC
TGGGGAAGGGAAGAAAGACAGTCGGTTTTCCCATTTGAAAGTGGGAAACCATTCAAAATA
CAAGTACTGGTTGAACCTGACCACTTCAAGGTTGCAGTGAATGATGCTCACTTGTTGCAG
TACAATCATCGGGTTAAAAAACTCAATGAAATCAGCAAACTGGGAATTTCTGGTGACATA
GACCTCACCAGTGCTTCATATACCATGATATAA

# Macromolecular_Interacting_Partner_15_GenBank_ID_Gene:
M57710

# Macromolecular_Interacting_Partner_15_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_15_Locus:
14q21-q22

# Macromolecular_Interacting_Partner_15_SNPs:
rs7157768; rs1047556; rs8012397; rs10149038; rs3188651; rs7160110; rs7160523; rs2147972; rs35624648; rs35652569; rs3188650; rs12161901; rs1130118; rs10629608; rs10629194; rs17095981; rs7159530; rs34212935; rs3742566; rs1009977; rs1009978; rs10140857; rs10146432; rs10148371; rs1042869; rs1042896; rs1042906; rs1042918; rs10498475; rs11001; rs11622740; rs13379284; rs15870; rs17128204; rs17128230; rs17128262; rs2075598; rs2075601; rs2075602; rs2075603; rs2182207; rs2274272; rs2274273; rs2296490; rs2340931; rs2340932; rs28405981; rs28415601; rs35954941; rs3818451; rs3825613; rs4644; rs7493394; rs8007614; rs8007620; rs8013027

# Macromolecular_Interacting_Partner_15_General_References:
2261464; 2402511; 2022338; 2009535; 7682704; 8253806; 9501082; 9582341

# Macromolecular_Interacting_Partner_15_References:
1733769; 1958194; 2303431; 2745433

# Macromolecular_Interacting_Partner_16_ID:
7895

# Macromolecular_Interacting_Partner_16_Name:
Myelin-associated glycoprotein precursor

# Macromolecular_Interacting_Partner_16_Synonyms:
Siglec-4a

# Macromolecular_Interacting_Partner_16_Gene_Name:
MAG

# Macromolecular_Interacting_Partner_16_Protein_Sequence:
>Myelinassociated glycoprotein precursor
MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY
FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD
LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL
GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP
VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED
GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF
KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH
CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA
QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK
NVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHS
DLGKRPTKDSYTLTEELAEYAEIRVK

# Macromolecular_Interacting_Partner_16_Number_of_Residues:
626

# Macromolecular_Interacting_Partner_16_Molecular_Weight:
69069

# Macromolecular_Interacting_Partner_16_Theoretical_pI:
4.69

# Macromolecular_Interacting_Partner_16_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_16_General_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Specific_Function:
Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha2,3- linked sialic acid

# Macromolecular_Interacting_Partner_16_Pathway:
Not Available

# Macromolecular_Interacting_Partner_16_Reaction:
Not Available

# Macromolecular_Interacting_Partner_16_Pfam_Domain_Function:
PF08205:C2-set_2;
PF07679:I-set;
PF00047:ig;
PF07686:V-set

# Macromolecular_Interacting_Partner_16_Signals:
1-19

# Macromolecular_Interacting_Partner_16_Transmembrane_Regions:
517-536

# Macromolecular_Interacting_Partner_16_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_16_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_16_GenBank_ID_Protein:
307156

# Macromolecular_Interacting_Partner_16_SwissProt_ID:
MAG_HUMAN (P20916)

# Macromolecular_Interacting_Partner_16_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_16_Genecard_id:
MAG

# Macromolecular_Interacting_Partner_16_Geneatlas_id:
MAG

# Macromolecular_Interacting_Partner_16_hgnc_id:
HGNC:6783

# Macromolecular_Interacting_Partner_16_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_16_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_16_Gene_Sequence:
>1881 bp
ATGATATTCCTCACGGCACTGCCTCTGTTCTGGATTATGATTTCAGCCTCCCGAGGGGGT
CACTGGGGTGCCTGGATGCCCTCGTCCATCTCGGCCTTCGAAGGCACGTGCGTCTCCATC
CCCTGCCGCTTTGACTTCCCGGATGAGCTGCGGCCCGCTGTGGTGCATGGTGTCTGGTAC
TTCAATAGCCCCTACCCCAAGAACTACCCCCCGGTGGTCTTCAAGTCGCGCACCCAAGTA
GTCCACGAGAGCTTCCAGGGCCGCAGCCGCCTCCTGGGGGACCTGGGCCTGCGAAACTGC
ACCCTCCTGCTCAGCAACGTCAGCCCCGAGCTGGGCGGGAAGTACTACTTCCGTGGGGAC
CTGGGCGGCTACAACCAGTACACCTTCTCAGAGCACAGTGTCCTGGATATCGTCAACACC
CCCAACATCGTGGTGCCCCCAGAGGTGGTGGCAGGCACGGAGGTGGAGGTCAGCTGCATG
GTGCCGGACAACTGCCCAGAGCTGCGCCCTGAGCTGAGCTGGCTGGGCCACGAGGGGCTG
GGGGAGCCCGCTGTGCTGGGCCGGCTGCGGGAGGACGAGGGCACCTGGGTGCAGGTGTCA
CTGCTGCACTTCGTGCCCACGAGGGAGGCCAACGGCCACAGGCTGGGCTGCCAGGCCTCC
TTCCCCAACACCACCCTGCAGTTCGAGGGCTACGCCAGCATGGACGTCAAGTACCCCCCG
GTGATTGTGGAGATGAACTCCTCGGTGGAGGCCATCGAGGGCTCCCACGTGAGCCTGCTC
TGTGGGGCTGACAGCAACCCCCCGCCGCTGCTGACCTGGATGCGGGACGGGACAGTCCTC
CGGGAGGCGGTGGCCGAGAGCCTGCTCCTGGAGCTGGAGGAGGTGACCCCCGCCGAAGAC
GGCGTCTATGCCTGCCTGGCCGAGAATGCCTATGGCCAGGACAACCGCACCGTGGGGCTC
AGTGTCATGTATGCACCCTGGAAGCCAACAGTGAACGGGACAATGGTGGCCGTAGAGGGG
GAGACGGTCTCTATCTTGTGCTCCACACAGAGCAACCCGGACCCTATTCTCACCATCTTC
AAGGAGAAGCAGATCCTGTCCACGGTCATCTACGAGAGCGAGCTGCAGCTGGAGCTGCCC
GCCGTGTCACCCGAGGATGATGGAGAGTACTGGTGTGTGGCTGAGAACCAGTATGGCCAG
AGGGCCACCGCCTTCAACCTGTCTGTGGAGTTCGCCCCTGTGCTCCTCCTGGAGTCCCAC
TGCGCGGCAGCCCGAGACACGGTGCAGTGCCTGTGCGTGGTGAAGTCCAACCCGGAGCCG
TCCGTGGCCTTTGAGCTGCCATCGCGCAATGTGACCGTGAACGAGAGCGAGCGGGAGTTC
GTGTACTCGGAGCGCAGCGGCCTCGTGCTCACCAGCATCCTCACGCTGCGGGGGCAGGCC
CAGGCCCCGCCCCGCGTCATCTGCACCGCGAGGAACCTCTATGGCGCCAAGAGCCTGGAG
CTGCCCTTCCAGGGAGCCCATCGACTGATGTGGGCCAAGATCGGGCCTGTGGGCGCCGTG
GTCGCCTTTGCCATCCTGATTGCCATCGTCTGCTACATTACCCAGACACGCAGGAAAAAG
AACGTGACAGAGAGCCCCAGCTTCTCGGCAGGGGACAACCCTCCCGTCCTGTTCAGCAGC
GACTTCCGCATCTCTGGGGCACCAGAGAAGTACGAGAGCGAGAGGCGCCTGGGATCTGAG
AGGAGGCTGCTGGGCCTTCGGGGTGAGCCCCCAGAGCTGGACCTGAGCTATTCTCACTCG
GACCTGGGGAAACGGCCCACCAAGGACAGCTACACGCTGACGGAGGAGCTAGCTGAGTAT
GCTGAAATCCGGGTCAAGTGA

# Macromolecular_Interacting_Partner_16_GenBank_ID_Gene:
M29273

# Macromolecular_Interacting_Partner_16_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_16_Locus:
19q13.1

# Macromolecular_Interacting_Partner_16_SNPs:
rs11084810; rs3746248; rs2301600; rs3746249; rs6510476; rs3214111; rs2285448; rs2285449; rs720309; rs12461927; rs10432275; rs720308; rs10414549; rs11669734; rs2269757; rs1964199; rs9304870; rs11670792; rs16970204; rs1034597; rs7249617; rs16970196; rs11879566; rs2285447; rs10414945; rs10411883; rs10402632; rs12185506; rs12974994; rs10411704; rs12974702; rs12185485; rs12608838; rs12608839; rs12608841; rs17705188; rs12609984; rs2301599; rs12609882; rs34074779; rs35237014; rs1126770; rs11550207; rs11550211; rs11550209; rs10670461; rs28508429; rs7248110; rs10557696; rs35311546; rs35676520; rs35662282; rs10678664; rs12976524; rs36141895; rs12974031; rs35981904; rs12972912; rs720307; rs41407744; rs10572816; rs10418687; rs36000294; rs35128289; rs12973162; rs10419210; rs35830760; rs2269756; rs12980495; rs35755792; rs12974264; rs12980521; rs2872113; rs12980281; rs35245828; rs11667965; rs3214112; rs35760221; rs12972861; rs8106733; rs16970192; rs12461872; rs12972627; rs12980353; rs2301598; rs12972629; rs12973965; rs12981372; rs12981415; rs3840948; rs12981404; rs10402233; rs10426926; rs11666282; rs11673191; rs11673522; rs12327820; rs12460277; rs12463142; rs12608868; rs12971321; rs12977217; rs12981829; rs16970218; rs17637981; rs17705279; rs2293689; rs3817623; rs4806126; rs7251432; rs7253838; rs7254710; rs756796; rs8101606

# Macromolecular_Interacting_Partner_16_General_References:
2476987; 2479762

# Macromolecular_Interacting_Partner_16_References:
1282933; 1706491; 2441800

# Macromolecular_Interacting_Partner_17_ID:
8062

# Macromolecular_Interacting_Partner_17_Name:
Midkine precursor

# Macromolecular_Interacting_Partner_17_Synonyms:
MK; Neurite outgrowth-promoting protein; Midgestation and kidney protein; Amphiregulin-associated protein; ARAP; Neurite outgrowth-promoting factor 2

# Macromolecular_Interacting_Partner_17_Gene_Name:
MDK

# Macromolecular_Interacting_Partner_17_Protein_Sequence:
>Midkine precursor
MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT
CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD

# Macromolecular_Interacting_Partner_17_Number_of_Residues:
143

# Macromolecular_Interacting_Partner_17_Molecular_Weight:
15585

# Macromolecular_Interacting_Partner_17_Theoretical_pI:
10.49

# Macromolecular_Interacting_Partner_17_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_17_General_Function:
Not Available

# Macromolecular_Interacting_Partner_17_Specific_Function:
Has heparin binding activity, and growth promoting activity. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development

# Macromolecular_Interacting_Partner_17_Pathway:
Not Available

# Macromolecular_Interacting_Partner_17_Reaction:
Not Available

# Macromolecular_Interacting_Partner_17_Pfam_Domain_Function:
PF01091:PTN_MK_C;
PF05196:PTN_MK_N

# Macromolecular_Interacting_Partner_17_Signals:
1-20

# Macromolecular_Interacting_Partner_17_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_17_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_17_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_17_GenBank_ID_Protein:
219929

# Macromolecular_Interacting_Partner_17_SwissProt_ID:
MK_HUMAN (P21741)

# Macromolecular_Interacting_Partner_17_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_17_Genecard_id:
MDK

# Macromolecular_Interacting_Partner_17_Geneatlas_id:
MDK

# Macromolecular_Interacting_Partner_17_hgnc_id:
HGNC:6972

# Macromolecular_Interacting_Partner_17_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_17_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_17_Gene_Sequence:
>432 bp
ATGCAGCACCGAGGCTTCCTCCTCCTCACCCTCCTCGCCCTGCTGGCGCTCACCTCCGCG
GTCGCCAAAAAGAAAGATAAGGTGAAGAAGGGCGGCCCGGGGAGCGAGTGCGCTGAGTGG
GCCTGGGGGCCCTGCACCCCCAGCAGCAAGGATTGCGGCGTGGGTTTCCGCGAGGGCACC
TGCGGGGCCCAGACCCAGCGCATCCGGTGCAGGGTGCCCTGCAACTGGAAGAAGGAGTTT
GGAGCCGACTGCAAGTACAAGTTTGAGAACTGGGGTGCGTGTGATGGGGGCACAGGCACC
AAAGTCCGCCAAGGCACCCTGAAGAAGGCGCGCTACAATGCTCAGTGCCAGGAGACCATC
CGCGTCACCAAGCCCTGCACCCCCAAGACCAAAGCAAAGGCCAAAGCCAAGAAAGGGAAG
GGAAAGGACTAG

# Macromolecular_Interacting_Partner_17_GenBank_ID_Gene:
D10604

# Macromolecular_Interacting_Partner_17_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_17_Locus:
11p11.2

# Macromolecular_Interacting_Partner_17_SNPs:
rs20542; rs1051037; rs14156; rs35871643; rs11557367; rs34274885; rs34089965; rs7481848; rs11557366; rs11557364; rs34261502; rs35324223; rs34864824; rs12801059; rs35008178; rs11038883; rs11822150; rs11823766; rs11827909; rs2046768; rs2229163; rs2279465; rs33968054; rs35646260; rs3740974; rs3740976; rs3740977; rs7107481; rs7936413

# Macromolecular_Interacting_Partner_17_General_References:
1639750; 2025291; 8471163; 1883381; 9384573

# Macromolecular_Interacting_Partner_17_References:
10632704

# Macromolecular_Interacting_Partner_18_ID:
7796

# Macromolecular_Interacting_Partner_18_Name:
ETS domain-containing protein Elk-4

# Macromolecular_Interacting_Partner_18_Synonyms:
Serum response factor accessory protein 1; SAP-1

# Macromolecular_Interacting_Partner_18_Gene_Name:
ELK4

# Macromolecular_Interacting_Partner_18_Protein_Sequence:
>ETS domaincontaining protein Elk4
MDSAITLWQFLLQLLQKPQNKHMICWTSNDGQFKLLQAEEVARLWGIRKNKPNMNYDKLS
RALRYYYVKNIIKKVNGQKFVYKFVSYPEILNMDPMTVGRIEGDCESLNFSEVSSSSKDV
ENGGKDKPPQPGAKTSSRNDYIHSGLYSSFTLNSLNSSNVKLFKLIKTENPAEKLAEKKS
PQEPTPSVIKFVTTPSKKPPVEPVAATISIGPSISPSSEETIQALETLVSPKLPSLEAPT
SASNVMTAFATTPPISSIPPLQEPPRTPSPPLSSHPDIDTDIDSVASQPMELPENLSLEP
KDQDSVLLEKDKVNNSSRSKKPKGLELAPTLVITSSDPSPLGILSPSLPTASLTPAFFSQ
TPIILTPSPLLSSIHFWSTLSPVAPLSPARLQGANTLFQFPSVLNSHGPFTLSGLDGPST
PGPFSPDLQKT

# Macromolecular_Interacting_Partner_18_Number_of_Residues:
431

# Macromolecular_Interacting_Partner_18_Molecular_Weight:
46900

# Macromolecular_Interacting_Partner_18_Theoretical_pI:
8.19

# Macromolecular_Interacting_Partner_18_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_18_General_Function:
Not Available

# Macromolecular_Interacting_Partner_18_Specific_Function:
Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously

# Macromolecular_Interacting_Partner_18_Pathway:
Not Available

# Macromolecular_Interacting_Partner_18_Reaction:
Not Available

# Macromolecular_Interacting_Partner_18_Pfam_Domain_Function:
PF00178:Ets

# Macromolecular_Interacting_Partner_18_Signals:
None

# Macromolecular_Interacting_Partner_18_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_18_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_18_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_18_GenBank_ID_Protein:
429186

# Macromolecular_Interacting_Partner_18_SwissProt_ID:
ELK4_HUMAN (P28324)

# Macromolecular_Interacting_Partner_18_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_18_Genecard_id:
ELK4

# Macromolecular_Interacting_Partner_18_Geneatlas_id:
ELK4

# Macromolecular_Interacting_Partner_18_hgnc_id:
HGNC:3326

# Macromolecular_Interacting_Partner_18_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_18_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_18_Gene_Sequence:
>1296 bp
ATGGACAGTGCTATCACCCTGTGGCAGTTCCTTCTTCAGCTCCTGCAGAAGCCTCAGAAC
AAGCACATGATCTGTTGGACCTCTAATGATGGGCAGTTTAAGCTTTTGCAGGCAGAAGAG
GTGGCTCGTCTCTGGGGGATTCGCAAGAACAAGCCTAACATGAATTATGACAAACTCAGC
CGAGCCCTCAGATACTATTATGTAAAGAATATCATCAAAAAAGTGAATGGTCAGAAGTTT
GTGTACAAGTTTGTCTCTTATCCAGAGATTTTGAACATGGATCCAATGACAGTGGGCAGG
ATTGAGGGTGACTGTGAAAGTTTAAACTTCAGTGAAGTCAGCAGCAGTTCCAAAGATGTG
GAGAATGGAGGGAAAGATAAACCACCTCAGCCTGGTGCCAAGACCTCTAGCCGCAATGAC
TACATACACTCTGGCTTATATTCTTCATTTACTCTCAACTCTTTGAACTCCTCCAATGTA
AAGCTTTTCAAATTGATAAAGACTGAGAATCCAGCCGAGAAACTGGCAGAGAAAAAATCT
CCTCAGGAGCCCACACCATCTGTCATCAAATTTGTCACGACACCTTCCAAAAAGCCACCA
GTTGAACCTGTTGCTGCCACCATTTCAATTGGCCCAAGTATTTCTCCATCTTCAGAAGAA
ACTATCCAAGCTTTGGAGACATTGGTTTCCCCAAAACTGCCTTCCCTGGAAGCCCCAACC
TCTGCCTCTAACGTAATGACTGCTTTTGCCACCACACCACCCATTTCGTCCATACCCCCT
TTGCAGGAACCTCCCAGAACACCTTCACCACCACTGAGTTCTCACCCAGACATCGACACA
GACATTGATTCAGTGGCTTCTCAGCCAATGGAACTTCCAGAGAATTTGTCTCTGGAGCCT
AAAGACCAGGATTCAGTCTTGCTAGAAAAGGACAAAGTAAATAATTCATCAAGATCCAAG
AAACCCAAAGGGTTAGGACTGGCACCCACCCTTGTGATCACGAGCAGTGATCCAAGCCCA
CTGGGAATACTGAGCCCATCTCTCCCTACAGCTTCTCTTACACCAGCATTTTTTTCACAG
ACACCCATCATACTGACTCCAAGCCCCTTGCTCTCCAGTATCCACTTCTGGAGTACTCTC
AGTCCTGTTGCTCCCCTAAGTCCAGCCAGACTGCAAGGTGCTAACACACTTTTCCAGTTT
CCTTCTGTACTGAACAGTCATGGGCCATTCACTCTGTCTGGGCTGGATGGACCTTCCACC
CCTGGCCCATTTTCCCCAGACCTACAGAAGACATAA

# Macromolecular_Interacting_Partner_18_GenBank_ID_Gene:
M85165

# Macromolecular_Interacting_Partner_18_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_18_Locus:
1q32

# Macromolecular_Interacting_Partner_18_SNPs:
rs1064406; rs3789461; rs12024592; rs11240541; rs4951247; rs2185811; rs3088136; rs12048882; rs6593957; rs4951248; rs7417466; rs7416757; rs12059129; rs4245717; rs13757; rs2867891; rs12023128; rs7549710; rs7523896; rs12731801; rs11590243; rs10900517; rs11577251; rs6593958; rs6593959; rs3204653; rs34515238; rs1064407; rs5780290; rs35619827; rs33980729; rs36121780; rs5780291; rs3208701; rs35018164; rs34851857; rs36056386; rs12048270; rs34193126; rs34460220; rs4951016; rs3065075; rs35020975; rs7416754; rs12048218; rs7416797; rs35663317; rs10635021; rs7416784; rs35267180; rs4951015; rs4951246; rs28630447; rs3208700; rs12025838; rs35375451; rs34724628; rs12749476; rs12738516; rs28629959; rs12732062; rs11379300; rs10701824; rs34310773; rs28495285; rs35245252; rs34087906; rs9729302; rs28435573; rs12759464; rs3204652; rs36044648; rs28571118; rs34180074; rs12727121; rs34779537; rs35219050; rs35600482; rs10793741; rs10900516; rs10900518; rs1114126; rs11579421; rs11579937; rs11580704; rs11581303; rs12039255; rs12080192; rs12087328; rs12125386; rs12565766; rs17347710; rs2226161; rs2867892; rs34103393; rs34451491; rs4130248; rs4130249; rs4573566; rs6661827; rs7518313

# Macromolecular_Interacting_Partner_18_General_References:
1339307; 8293474; 9734357

# Macromolecular_Interacting_Partner_18_References:
1350885; 1689485; 2019586; 3242555

# Macromolecular_Interacting_Partner_19_ID:
8202

# Macromolecular_Interacting_Partner_19_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_19_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_19_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_19_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_19_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_19_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_19_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_19_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_19_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_19_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_19_Pathway:
Not Available

# Macromolecular_Interacting_Partner_19_Reaction:
Not Available

# Macromolecular_Interacting_Partner_19_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_19_Signals:
None

# Macromolecular_Interacting_Partner_19_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_19_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_19_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_19_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_19_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_19_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_19_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_19_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_19_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_19_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_19_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_19_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_19_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_19_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_19_Locus:
10q22

# Macromolecular_Interacting_Partner_19_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_19_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_19_References:
11739312

# Macromolecular_Interacting_Partner_20_ID:
8403

# Macromolecular_Interacting_Partner_20_Name:
ADAMTS-like protein 1 precursor

# Macromolecular_Interacting_Partner_20_Synonyms:
ADAMTSL-1; Punctin-1

# Macromolecular_Interacting_Partner_20_Gene_Name:
ADAMTSL1

# Macromolecular_Interacting_Partner_20_Protein_Sequence:
>
ADAMTSlike protein 1 precursorMECCRRATPGTLLLFLAFLLLSSRTARSEE
DRDGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRA
QQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLD
MCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPY
GSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGP
LTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSN
RVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSS
SCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTV
TCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQ
AQELEEGAAVSEEPS

# Macromolecular_Interacting_Partner_20_Number_of_Residues:
525

# Macromolecular_Interacting_Partner_20_Molecular_Weight:
58417

# Macromolecular_Interacting_Partner_20_Theoretical_pI:
6.65

# Macromolecular_Interacting_Partner_20_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_20_General_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Pathway:
Not Available

# Macromolecular_Interacting_Partner_20_Reaction:
Not Available

# Macromolecular_Interacting_Partner_20_Pfam_Domain_Function:
PF00090:TSP_1

# Macromolecular_Interacting_Partner_20_Signals:
1-28

# Macromolecular_Interacting_Partner_20_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_20_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_20_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_20_GenBank_ID_Protein:
15099921

# Macromolecular_Interacting_Partner_20_SwissProt_ID:
ATL1_HUMAN (Q8N6G6)

# Macromolecular_Interacting_Partner_20_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_20_Genecard_id:
ADAMTSL1

# Macromolecular_Interacting_Partner_20_Geneatlas_id:
ADAMTSL1

# Macromolecular_Interacting_Partner_20_hgnc_id:
HGNC:14632

# Macromolecular_Interacting_Partner_20_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_20_Subcellular_Location:
Secreted protein; extracellular space; extracellular matrix

# Macromolecular_Interacting_Partner_20_Gene_Sequence:
>1578 bp
ATGGAATGCTGCCGTCGGGCAACTCCTGGCACACTGCTCCTCTTTCTGGCTTTCCTGCTC
CTGAGTTCCAGGACCGCACGCTCCGAGGAGGACCGGGACGGCCTATGGGATGCCTGGGGC
CCATGGAGTGAATGCTCACGCACCTGCGGGGGTGGGGCCGCCAACTCTCTGAGGCGCTGC
CTGAGCAGCAAGAGCTGTGAAGGAAGAAATATCCGATACAGAACATGCAGTAATGTGGAC
TGCCCACCAGAAGCAGGTGATTTCCGAGCTCAGCAATGCTCAGCTCATAATGATGTCAAG
CACCATGGCCAGTTTTATGAATGGCTTCCTGTGTCTAATGACCCTGACAACCCATGTTCA
CTCAAGTGCCAAGCCAAAGGAACAACCCTGGTTGTTGAACTAGCACCTAAGGTCTTAGAT
GGTACGCGTTGCTATACAGAATCTTTGGATATGTGCATCAGTGGTTTATGCCAAATTGTT
GGCTGCGATCACCAGCTGGGAAGCACCGTCAAGGAAGATAACTGTGGGGTCTGCAACGGA
GATGGGTCCACCTGCCGGCTGGTCCGAGGGCAGTATAAATCCCAGCTCTCCGCAACCAAA
TCGGATGATACTGTGGTTGCAATTCCCTATGGAAGTAGACATATTCGCCTTGTCTTAAAA
GGTCCTGATCACTTATATCTGGAAACCAAAACCCTCCAGGGGACTAAAGGTGAAAACAGT
CTCAGCTCCACAGGAACTTTCCTTGTGGACAATTCTAGTGTGGACTTCCAGAAATTTCCA
GACAAAGAGATACTGAGAATGGCTGGACCACTCACAGCAGATTTCATTGTCAAGATTCGT
AACTCGGGCTCCGCTGACAGTACAGTCCAGTTCATCTTCTATCAACCCATCATCCACCGA
TGGAGGGAGACGGATTTCTTTCCTTGCTCAGCAACCTGTGGAGGAGGTTATCAGCTGACA
TCGGCTGAGTGCTACGATCTGAGGAGCAACCGTGTGGTTGCTGACCAATACTGTCACTAT
TACCCAGAGAACATCAAACCCAAACCCAAGCTTCAGGAGTGCAACTTGGATCCTTGTCCA
GCCAGTGACGGATACAAGCAGATCATGCCTTATGACCTCTACCATCCCCTTCCTCGGTGG
GAGGCCACCCCATGGACCGCGTGCTCCTCCTCGTGTGGGGGGGGCATCCAGAGCCGGGCA
GTTTCCTGTGTGGAGGAGGACATCCAGGGGCATGTCACTTCAGTGGAAGAGTGGAAATGC
ATGTACACCCCTAAGATGCCCATCGCGCAGCCCTGCAACATTTTTGACTGCCCTAAATGG
CTGGCACAGGAGTGGTCTCCGTGCACAGTGACGTGTGGCCAGGGCCTCAGATACCGTGTG
GTCCTCTGCATCGACCATCGAGGAATGCACACAGGAGGCTGTAGCCCAAAAACAAAGCCC
CACATAAAAGAGGAATGCATCGTACCCACTCCCTGCTATAAACCCAAAGAGAAACTTCCA
GTCGAGGCCAAGTTGCCATGGTTCAAACAAGCTCAAGAGCTAGAAGAAGGAGCTGCTGTG
TCAGAGGAGCCCTCGTAA

# Macromolecular_Interacting_Partner_20_GenBank_ID_Gene:
AF176313

# Macromolecular_Interacting_Partner_20_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_20_Locus:
9p22.2-p22.1

# Macromolecular_Interacting_Partner_20_SNPs:
rs776755; rs16936832; rs13293151; rs2277160; rs1412672; rs776761; rs776760; rs16923421; rs10963719; rs776785; rs1360566; rs1341063; rs2811802; rs776758; rs547927; rs2066254; rs702207; rs1329720; rs530120; rs566332; rs1341060; rs1928534; rs517764; rs776764; rs2570569; rs1341070; rs1889010; rs1889007; rs1341059; rs1147795; rs559385; rs702204; rs1539000; rs1341062; rs1412673; rs1889009; rs1538999; rs776780; rs556720; rs702208; rs572429; rs1891042; rs526826; rs1361533; rs1281349; rs4961653; rs11792038; rs1999489; rs12554902; rs7047451; rs4977520; rs702202; rs10810993; rs10756975; rs10511661; rs2149875; rs518607; rs10963665; rs7867475; rs7036515; rs10756969; rs7045779; rs1821376; rs1832746; rs11794207; rs4977292; rs10963622; rs1341061; rs4977341; rs2065467; rs10733355; rs6475238; rs10963684; rs1332708; rs7875881; rs6475236; rs944719; rs10963639; rs702206; rs10963693; rs4977522; rs10963713; rs568935; rs10756977; rs1582017; rs776770; rs702209; rs1934931; rs1341058; rs1006022; rs10810981; rs7863523; rs4433237; rs6475230; rs7864622; rs10756981; rs10756970; rs10811002; rs7039094; rs6475226; rs4961652; rs7862714; rs7023164; rs6475232; rs7874290; rs10756976; rs10963615; rs949682; rs1889005; rs1832747; rs10811022; rs1332706; rs7041523; rs2225568; rs4607718; rs7031222; rs7864727; rs1332712; rs10811006; rs2779127; rs3739569; rs4961654; rs776771; rs6475228; rs2096067; rs7029420; rs7027141; rs7029284; rs1341057; rs7019399; rs4977340; rs1582016; rs944720; rs10811007; rs2779125; rs1889006; rs10756982; rs483950; rs2482972; rs6475227; rs7856703; rs870019; rs7042159; rs10963673; rs2095100; rs10963729; rs16936757; rs2184002; rs776790; rs482009; rs2383077; rs1576897; rs16936909; rs7388822; rs7390384; rs7042143; rs10810985; rs1332707; rs7859309; rs10963624; rs7874890; rs12345096; rs13300372; rs702205; rs13299098; rs7025447; rs10481563; rs10963689; rs10116116; rs1341067; rs10756973; rs12003267; rs1576900; rs7865575; rs10963629; rs1281352; rs7046774; rs17229989; rs7874996; rs1417640; rs11794163; rs1934932; rs7019258; rs2383075; rs776773; rs11789527; rs947144; rs10810991; rs10963669; rs10435773; rs12001790; rs10810974; rs11790127; rs11794157; rs7018651; rs17229415; rs2153415; rs10963675; rs11788108; rs12001049; rs7863071; rs16936815; rs7022259; rs776779; rs776756; rs10963691; rs10963662; rs2383079; rs1010529; rs11789989; rs4977339; rs776777; rs12554668; rs16936951; rs16936796; rs951227; rs11793923; rs776794; rs776754; rs776748; rs2482971; rs10115066; rs12684130; rs12000949; rs10811012; rs776781; rs7023698; rs1083111; rs10963664; rs10810997; rs4474116; rs521546; rs479642; rs7027296; rs16936905; rs17206601; rs10756968; rs16936779; rs11999281; rs10963630; rs10732338; rs12237559; rs1341069; rs12684350; rs10810995; rs552677; rs4961650; rs10738515; rs776776; rs7465987; rs1591108; rs1341065; rs4977338; rs10963667; rs1891043; rs488627; rs10810988; rs10963695; rs16936853; rs9792478; rs12000950; rs10756974; rs2811800; rs16936911; rs10810992; rs7036067; rs10481564; rs10810999; rs572484; rs17804334; rs702203; rs11792817; rs10811008; rs2153416; rs776766; rs11789831; rs7849918; rs1928535; rs12002347; rs776782; rs2383076; rs13298611; rs776791; rs532101; rs1341066; rs11789771; rs552295; rs12005242; rs776769; rs7868375; rs10756972; rs10738514; rs7028087; rs10511637; rs10810986; rs6475225; rs10963676; rs11795307; rs1360567; rs17803363; rs17228625; rs521911; rs9696562; rs10756980; rs10963640; rs776778; rs17209122; rs529274; rs7019175; rs6475237; rs12001004; rs16936967; rs4451401; rs10511657; rs12554550; rs10963626; rs776753; rs10115096; rs10810984; rs776784; rs4977264; rs10810975; rs7863100; rs10963710; rs2000117; rs7466067; rs944718; rs10963642; rs16936961; rs10810989; rs10963685; rs573120; rs776768; rs12352788; rs2507120; rs10810996; rs575507; rs7023695; rs12003118; rs4977248; rs12345939; rs10119114; rs1856893; rs7031043; rs12001288; rs4961656; rs7388795; rs776762; rs1412671; rs776763; rs4977511; rs7868026; rs10810994; rs488536; rs10511660; rs4961651; rs16936958; rs575995; rs12684345; rs6475233; rs7389933; rs12001382; rs10963668; rs776789; rs10810976; rs10810987; rs10810982; rs2487477; rs480335; rs16936827; rs12553147; rs11795292; rs10756978; rs10963623; rs10963627; rs7466047; rs7023718; rs2151152; rs11787618; rs16936777; rs10811014; rs10963712; rs10217409; rs13292511; rs17230881; rs1361534; rs10963731; rs12686263; rs12352272; rs12343163; rs13300724; rs10963650; rs16936896; rs1433822; rs17801150; rs575155; rs10963688; rs6475234; rs13297223; rs1889008; rs776569; rs1930265; rs1361535; rs1832748; rs7043878; rs17230699; rs12344654; rs17207294; rs11789251; rs13293473; rs554082; rs13293062; rs7023843; rs12379776; rs10115095; rs10810980; rs35688527; rs7389198; rs13295522; rs7020435; rs4977326; rs10963633; rs10963670; rs12552620; rs17207339; rs12005343; rs10963726; rs7040355; rs13298248; rs13287935; rs13287455; rs12005478; rs10217753; rs10810998; rs12376154; rs16936780; rs7848360; rs10963718; rs7023368; rs16936897; rs10810983; rs2153621; rs16936783; rs16936798; rs1576899; rs13294657; rs10963686; rs10963649; rs10738513; rs7855730; rs10123053; rs13301259; rs16936919; rs10120778; rs2811798; rs16936935; rs13302086; rs7041415; rs11789724; rs4961657; rs7341804; rs7466106; rs10963692; rs10963682; rs1281351; rs10963672; rs10511658; rs11791689; rs11532901; rs1412670; rs16936801; rs10811010; rs10963703; rs4977510; rs7850641; rs13301913; rs1855120; rs10811020; rs776767; rs13296911; rs10810979; rs2811796; rs17206965; rs7465974; rs1930263; rs16936808; rs12337201; rs7850738; rs1544308; rs12380512; rs7388806; rs2151153; rs13292240; rs12683032; rs1576901; rs17206657; rs16936831; rs542956; rs13294696; rs7872574; rs776783; rs7870255; rs35277167; rs1856894; rs9919038; rs13295269; rs7867784; rs12686602; rs13293767; rs10963711; rs12336626; rs7028404; rs17229477; rs776752; rs947143; rs1832638; rs17804352; rs12341667; rs9407925; rs12686125; rs7023504; rs3927893; rs12376289; rs12336527; rs776788; rs16936819; rs1332711; rs10116980; rs11793849; rs7019410; rs7041815; rs7031573; rs12684149; rs16936788; rs1332709; rs16936903; rs7874771; rs12004058; rs7020916; rs10963636; rs572616; rs12338677; rs776757; rs10963732; rs7021213; rs10811003; rs1147797; rs17207028; rs12336779; rs13298257; rs9775632; rs10811001; rs16936895; rs776749; rs776750; rs10963621; rs7867817; rs13288800; rs7044968; rs12685259; rs10963683; rs2149876; rs7852457; rs10810978; rs13290343; rs10811018; rs10963661; rs12349321; rs12342475; rs502981; rs12000315; rs7469307; rs10963687; rs10756979; rs1009309; rs1970943; rs10963734; rs2184001; rs10963634; rs10811015; rs7390343; rs11793203; rs10963666; rs573484; rs7040072; rs4977387; rs951226; rs10811019; rs7868185; rs13299349; rs7468653; rs11793774; rs7852955; rs539785; rs10811011; rs12686145; rs776751; rs10963735; rs12339807; rs7390426; rs7044243; rs7034394; rs7864856; rs10963620; rs13300518; rs7023547; rs1888066; rs16936794; rs7855050; rs7027894; rs2225570; rs10115933; rs10963707; rs10511659; rs11999519; rs12337572; rs17229526; rs7867370; rs16936917; rs7035957; rs4355867; rs12551569; rs10963625; rs1576896; rs10810973; rs7875093; rs13292378; rs7850813; rs776765; rs6475221; rs10963657; rs10963704; rs10811021; rs16936775; rs7038168; rs10811000; rs16936817; rs7850363; rs16936818; rs16936963; rs10963694; rs4977287; rs16936852; rs10963680; rs1341071; rs7850469; rs12554156; rs10116792; rs10963696; rs486145; rs10963681; rs7867664; rs12000817; rs16936778; rs10963671; rs10732339; rs2507119; rs7019792; rs13294727; rs1576898; rs17801409; rs4431681; rs10963635; rs10963714; rs578602; rs1281350; rs522039; rs10511638; rs16936748; rs13286264; rs2507121; rs41268981; rs41298157; rs3833713; rs35537367; rs34092810; rs10963724; rs11364021; rs12340239; rs7858746; rs2779126; rs13292616; rs776793; rs36077277; rs13294946; rs36169929; rs36091497; rs35416683; rs34876631; rs36022692; rs9406756; rs36057123; rs10963716; rs34645177; rs10708564; rs4977282; rs5016291; rs36013602; rs33953582; rs2891130; rs34439536; rs35140301; rs35060497; rs776775; rs35316103; rs35606703; rs13297702; rs34631052; rs34680131; rs10963701; rs13288820; rs13299810; rs2210057; rs34726555; rs35875473; rs13292199; rs12236787; rs36031735; rs34052626; rs9792510; rs36168513; rs35803069; rs10963614; rs34506111; rs13283108; rs544787; rs34597500; rs35108345; rs35071367; rs2383081; rs13286126; rs11460080; rs34654911; rs36167516; rs34328687; rs34050557; rs4400483; rs10811016; rs13287162; rs13286127; rs34816420; rs7018618; rs34436773; rs41302220; rs7023090; rs34253990; rs2779122; rs28796737; rs36195957; rs13286678; rs12337535; rs34005652; rs34330935; rs13300504; rs7036374; rs35932920; rs10570129; rs5896791; rs3837242; rs9407930; rs733148; rs12340914; rs34781772; rs13299323; rs10963617; rs13290738; rs12342640; rs10963728; rs35544370; rs34619899; rs7021207; rs4636296; rs36058307; rs13302831; rs34220297; rs35733288; rs7039018; rs34097794; rs13296026; rs34692510; rs12345056; rs4295751; rs12684681; rs35418109; rs10963616; rs776787; rs34442889; rs34095656; rs11460867; rs35885690; rs16936912; rs10963677; rs34142086; rs13283592; rs34383159; rs10963705; rs13301966; rs12339412; rs13295267; rs35253110; rs7469878; rs13287437; rs13298928; rs36189694; rs13296183; rs33924965; rs1147796; rs35647604; rs36181847; rs36140539; rs11793105; rs34049116; rs34846596; rs33982024; rs34918407; rs34381763; rs11446181; rs13283440; rs13296717; rs35554258; rs7041646; rs34946727; rs34476081; rs10963706; rs10963632; rs13300153; rs13289970; rs35356159; rs10555563; rs776759; rs11506410; rs3860972; rs776786; rs4977506; rs36146200; rs10963619; rs36154944; rs34178821; rs34040817; rs35418018; rs35808221; rs13286754; rs33918828; rs35042945; rs10963721; rs12682798; rs35154592; rs34869167; rs5896798; rs4385562; rs9406754; rs944721; rs33996142; rs10811004; rs13283382; rs34965386; rs13289145; rs35382307; rs9650689; rs2779123; rs10963628; rs10557285; rs34798328; rs10963736; rs10963647; rs9695326; rs10963679; rs10963641; rs41268979; rs2507118; rs35177614; rs3802340; rs34077257; rs35418231; rs34196549; rs10963699; rs35770069; rs34862602; rs36112027; rs34157511; rs12346293; rs5896793; rs34531876; rs35371614; rs13298652; rs35559107; rs11313686; rs35978243; rs34630851; rs1891041; rs12342497; rs13286696; rs12342495; rs34301959; rs13285912; rs34454766; rs10645309; rs33916252; rs5896787; rs35053966; rs10963708; rs36154545; rs36006423; rs35538858; rs13300862; rs2487476; rs10963723; rs35926683; rs34983844; rs36175671; rs34312083; rs33950212; rs13302220; rs35339048; rs13286598; rs35568696; rs36035302; rs34436139; rs4287034; rs35629404; rs34284261; rs34821893; rs1332705; rs7874968; rs5896795; rs776792; rs12341996; rs41311420; rs35417806; rs10811017; rs35264977; rs34166830; rs35182657; rs34628447; rs13301604; rs10532151; rs13286493; rs34109507; rs34621079; rs2095101; rs9407932; rs10963656; rs7389813; rs34068102; rs35349026; rs35642330; rs13290564; rs34201579; rs9802884; rs35461401; rs35255030; rs36145980; rs13291526; rs34343707; rs34263425; rs13286871; rs5896790; rs35159088; rs34238776; rs35915496; rs12216898; rs7466375; rs35640170; rs35629128; rs36104735; rs34450429; rs35245238; rs484122; rs13285951; rs12005770; rs13288110; rs35093359; rs9407931; rs10963702; rs41433052; rs7847401; rs7041704; rs2185376; rs35305418; rs519115; rs512837; rs5896789; rs34466221; rs34498930; rs13294711; rs35319836; rs35591011; rs35043947; rs7030986; rs35850320; rs36207208; rs28811624; rs12344921; rs7038860; rs10673652; rs34979585; rs5896792; rs13298947; rs10963618; rs2184003; rs35996734; rs1999488; rs34824201; rs35669972; rs34185587; rs1341064; rs13300270; rs4588951; rs35101804; rs10963674; rs12342110; rs34795909; rs35812809; rs36084146; rs10963651; rs28580690; rs10963725; rs34430407; rs34716128; rs13286662; rs10963678; rs776774; rs16936960; rs10963730; rs28631522; rs34126908; rs12683814; rs35857771; rs35231922; rs9792511; rs17209283; rs35463792; rs7045856; rs2082579; rs34101030; rs12379267; rs2383080; rs35284183; rs10963700; rs28512474; rs36091514; rs2811803; rs34169826; rs776747; rs13297207; rs13296581; rs13291036; rs36158955; rs34806424; rs13292412; rs34641518; rs35334357; rs5013435; rs28744598; rs34093249; rs13294947; rs10963690; rs12342501; rs36185606; rs13291906; rs34440975; rs34558329; rs28660058; rs36171685; rs10963631; rs28802339; rs34391322; rs34470501; rs34069867; rs35557854; rs7029381; rs35153132; rs35420327; rs35364702; rs34081958; rs35743622; rs34966179; rs545786; rs13284579; rs34610864; rs11315484; rs2383074; rs7871056; rs11793072; rs10963715; rs13288808; rs2482968; rs11387371; rs10963653; rs36105430; rs12340667; rs7024835; rs7465902; rs35452459; rs13302184; rs13286679; rs10963697; rs34918884; rs13300791; rs13301985; rs34854828; rs34153311; rs12379557; rs34540271; rs35214924; rs28548145; rs35568743; rs534452; rs10653217; rs4457426; rs11460866; rs1930264; rs35471468; rs35196962; rs35664109; rs1856895; rs10963663; rs34587944; rs34867394; rs34217170; rs35691010; rs11278457; rs11793073; rs1083110; rs12682670; rs7024939; rs11418722; rs12348453; rs1889004; rs35732709; rs10963698; rs35986324; rs12554270; rs34361890; rs10544641; rs34038101; rs10644915; rs10963720; rs11506411; rs10963638; rs13288960; rs35582749; rs35511233; rs7872766; rs35116229; rs13292958; rs2225569; rs34023792; rs2487475; rs34630583; rs34234309; rs4977507; rs36181877; rs12003196; rs34514562; rs574314; rs28635605; rs34098829; rs1341068; rs12348263; rs12350602; rs34050702; rs5896799; rs36181409; rs35010109; rs34164687; rs2095102; rs34706021; rs34453171; rs34570847; rs41302063; rs12344258; rs35083940; rs10963722; rs35601420; rs36150798; rs1412674; rs5896794; rs41268977; rs35136150; rs35711586; rs9792675; rs7038433; rs34469008; rs11793012; rs35270230; rs13296027; rs9407926; rs13294944; rs35990368; rs4344171; rs7865199; rs4385563; rs35477457; rs36020134; rs35847846; rs548315; rs5896797; rs1832637; rs13301770; rs13301602; rs11339613; rs35899945; rs12380455; rs12683886; rs519878; rs10696982; rs1332710; rs34025313; rs13295553; rs12006403; rs35189980; rs34279293; rs1578428; rs34341152; rs35599040; rs2210501; rs1411151; rs7039052; rs5896788; rs7045855; rs28709272; rs34070469; rs13286585; rs16923418; rs41305317; rs35520713; rs12351354; rs34129180; rs5896796; rs10963709; rs35366579; rs16936920; rs7847776; rs13295832; rs34382100; rs34509994; rs35220169; rs5896786; rs2383078; rs12554532; rs4994335; rs12115542; rs41268975; rs7018593; rs34596088; rs35228238; rs28736826; rs36076173; rs13287108; rs13292276; rs28403986; rs12351319; rs7032837; rs10119856; rs13294903; rs34058021; rs35665436; rs12001313; rs35264941; rs4961658; rs12340707; rs34900718; rs13302136; rs35518030; rs16936915; rs35694929; rs7025364; rs4327937; rs35874115; rs35094886; rs34831037; rs34304159; rs36060882; rs4406499; rs10123481; rs10123802; rs10511656; rs10756965; rs10756966; rs10756967; rs10810972; rs10963613; rs10963738; rs1147794; rs12342476; rs12553779; rs1417036; rs1417037; rs1417641; rs1433816; rs16936735; rs16936745; rs17206286; rs1888067; rs1888068; rs1888069; rs1999174; rs2507117; rs3898100; rs476104; rs476196; rs476460; rs480814; rs487258; rs487882; rs507556; rs515375; rs532543; rs542826; rs563805; rs574090; rs574151; rs579517; rs580568; rs6475220; rs748108; rs7867766; rs944716; rs944717; rs954183

# Macromolecular_Interacting_Partner_20_General_References:
11805097; 12975309

# Macromolecular_Interacting_Partner_20_References:
1527055; 1557410; 2559078; 2777788

End of HMDB00024

Beginning of HMDB00026
# Accession_No:
HMDB00026

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-05-23 10:44:44

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Ureidopropionic acid

# Description:
A breakdown product of pyrimidines.  Enzyme deficiencies in pyrimidine metabolism are associated with a risk for severe toxicity against the antineoplastic agent 5-fluorouracil.

# Synonyms:
3-Ureido-propionate; 3-Ureidopropionate; 3-Ureidopropionic acid; Carbamoyl-b-Ala-OH; N-(aminocarbonyl)-'b-Alanine; N-(aminocarbonyl)-beta-Alanine; N-Carbamoyl-beta-alanine; Ureidopropionate; Ureidopropionic acid; beta-Ureidopropionate; beta-Ureidopropionic acid; Carbamoyl-beta-Ala-OH

# Chemical_IUPAC_Name:
3-carbamoylaminopropanoic acid

# Chemical_Formula:
C4H8N2O3

# Chemical_Structure:
tbl_chemical:::HMDB00026_ZOOM.png:::119283138154179312

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00026_THUMB.png:::119283137958936059

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
carboxylic acid; urea

# Taxonomy_Biofunction:
Component of beta-Alanine metabolism; Component of Pantothenate and CoA biosynthesis; Component of Pyrimidine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
132.05350

# Molecular_Weight_Avg:
132.11792

# Smiles_String_isomeric:
NC(=O)NCCC(O)=O

# Smiles_String_canonical:
NC(=O)NCCC(O)=O

# KEGG_Compound_ID:
C02642

# BioCyc_ID:
3-UREIDO-PROPIONATE

# PubChem_CID:
111

# PubChem_SID:
10322862; 11534299; 111024; 8148862; 210160; 2017; 8145171; 564993; 5179319; 8150463; 5621

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
40270

# Wikipedia_ID:
Not Available

# METLIN_ID:
5097

# Ref_ID:
11675655; 16513432; 16305582; 12798197; 2936452; 12386128

# ChEBI_ID:
18261

# CAS_Registry_Number:
462-88-4

# InChI:
InChI=1/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)

# Synthesis_Reference:
Journal of Fermentation Technology  (1978),  56(5),  492-8.

# Melting_Point:
170 oC

# Melting_Point_predicted:
37.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
20.9 mg/mL [BEILSTEIN]

# H2O_Solubility_Predicted:
52.7 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-0.98 [Predicted by ALOGPS]; -1.6 [Predicted by PubChem via XLOGP]; -1.34 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C02642.mol:::1132723802109157706

# SDF_File_[Text]:
tbl_chemical:::HMDB00026.sdf:::119283137601371321

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00026.pdb:::119283137791447418

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::050123_P00_03_IS_1DP_presat.png:::114711936715810941

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::050123_P00_03_IS_1DP_presat.zip:::114711936717993213

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050123_P00_03_IS_1DP_Assigned.png:::114711936720049209

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050123_P00_03_IS_2DHSQC_2204.png:::117520945313586096

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050123_P00_03_IS_2DHSQC_2204.zip:::117520945320179055

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050123_P00_03_IS_2DHSQC_2204_Assigned.png:::117520945339588857

# Predicted_H_NMR_Spectrum:
tbl_chemical:::3-Ureidopropionic acid.gif:::1132732100015877713

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00026_peaks.txt:::1156309494538825963

# Predicted_C_NMR_Spectrum:
tbl_chemical:::3-Ureidopropionic acid_C.gif:::11327376604013278

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00026_peaks.txt:::1156310686369784435

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00026L.png:::117555261793792483; Medium Energy:tbl_ms:::HMDB00026M.png:::117555266909968250; High Energy:tbl_ms:::HMDB00026H.png:::117555270752521489

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Urine

# Concentration_[Normal]:
Urine	2.23 (1.48 - 2.81)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	16513432
Urine	0.88	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	12798197
Urine	0.88	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	12798197


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Beta-Ureidopropionase (UP) Deficiency; Combined Uraciluria-Thyminuria

# Pathway_Names:
Pantothenate and CoA biosynthesis

# Pathway_Images:
Not Available

# KEGG_Images:
map00770

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5814

# Metabolic_Enzyme_1_Name:
Dihydropyrimidinase

# Metabolic_Enzyme_1_Synonyms:
DHPase; Hydantoinase; DHP

# Metabolic_Enzyme_1_Gene_Name:
DPYS

# Metabolic_Enzyme_1_Protein_Sequence:
>Dihydropyrimidinase
MAAPSRLLIRGGRVVNDDFSEVADVLVEDGVVRALGHDLLPPGGAPAGLRVLDAAGKLVL
PGGIDTHTHMQFPFMGSRSIDDFHQGTKAALSGGTTMIIDFAIPQKGGSLIEAFETWRSW
ADPKVCCDYSLHVAVTWWSDQVKEEMKILVQDKGVNSFKMFMAYKDLYMVTDLELYEAFS
RCKEIGAIAQVHAENGDLIAEGAKKMLALGITGPEGHELCRPEAVEAEATLRAITIASAV
NCPLYIVHVMSKSAAKVIADARRDGKVVYGEPIAASLGTDGTHYWNKEWHHAAHHVMGPP
LRPDPSTPDFLMNLLANDDLTTTGTDNCTFNTCQKALGKDDFTKIPNGVNGVEDRMSVIW
EKGVHSGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIVIWDPKGTRTISAKTHH
QAVNFNIFEGMVCHGVPLVTISRGKVVYEAGVFSVTAGDGKFIPRKPFAEYIYKRIKQRD
RTCTPTPVERAPYKGEVATLKSRVTKEDATAGTRKQAHP

# Metabolic_Enzyme_1_Number_of_Residues:
519

# Metabolic_Enzyme_1_Molecular_Weight:
56630

# Metabolic_Enzyme_1_Theoretical_pI:
7.28

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
5,6-dihydrouracil + H(2)O = 3- ureidopropanoate

# Metabolic_Enzyme_1_Pathway:
map00240  Pyrimidine metabolism;
 map00410  beta-Alanine metabolism;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_1_Reaction:
5,6-dihydrouracil + H2O = 3-ureidopropanoate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01979:Amidohydro_1

# Metabolic_Enzyme_1_Signals:
1-2

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.5.2.2

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1330236

# Metabolic_Enzyme_1_SwissProt_ID:
DPYS_HUMAN (Q14117)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
DPYS

# Metabolic_Enzyme_1_Geneatlas_id:
DPYS

# Metabolic_Enzyme_1_hgnc_id:
HGNC:3013

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_1_Gene_Sequence:
>1560 bp
ATGGCGGCGCCCTCGCGGCTCCTGATCCGCGGGGGTCGCGTGGTCAACGATGACTTCTCG
GAGGTGGCCGACGTGCTGGTGGAGGACGGCGTGGTGCGGGCACTCGGGCACGACCTGCTG
CCTCCCGGGGGCGCTCCTGCGGGGCTGCGGGTCCTCGACGCCGCCGGCAAGCTCGTCCTG
CCCGGAGGCATCGACACACACACGCACATGCAGTTCCCCTTCATGGGCTCGCGGTCCATC
GACGACTTCCACCAGGGCACCAAGGCTGCTCTCTCAGGAGGCACCACCATGATTATTGAT
TTCGCCATTCCTCAGAAAGGTGGCTCCCTCATTGAGGCCTTCGAGACCTGGCGAAGCTGG
GCTGATCCCAAAGTTTGCTGCGACTACAGCCTTCATGTGGCAGTGACGTGGTGGAGTGAC
CAGGTTAAAGAAGAAATGAAAATCCTTGTGCAAGATAAAGGTGTTAACTCTTTCAAGATG
TTTATGGCCTATAAAGATCTGTACATGGTGACAGACCTGGAGCTGTACGAAGCCTTCTCT
CGGTGCAAGGAAATTGGAGCAATTGCCCAGGTCCATGCGGAAAATGGAGACTTAATTGCA
GAGGGAGCAAAGAAGATGTTGGCTCTGGGGATAACAGGCCCTGAGGGCCACGAGCTGTGC
CGCCCAGAGGCAGTGGAGGCAGAGGCCACGCTGAGAGCCATCACCATAGCCAGCGCTGTG
AACTGTCCTCTCTACATTGTGCATGTGATGAGCAAGTCTGCAGCTAAGGTGATAGCGGAT
GCAAGGAGAGATGGGAAGGTGGTCTATGGTGAACCCATAGCAGCCAGTCTTGGCACAGAT
GGCACTCACTACTGGAATAAAGAATGGCACCATGCAGCCCACCATGTCATGGGTCCACCT
TTGCGACCAGACCCCTCAACACCCGACTTCCTCATGAATCTGTTGGCTAATGATGATCTA
ACCACAACAGGGACTGATAACTGCACTTTCAACACCTGCCAGAAAGCTCTTGGGAAGGAT
GATTTTACCAAGATCCCCAATGGGGTGAATGGTGTTGAAGATCGGATGTCCGTAATATGG
GAAAAAGGCGTGCATAGTGGTAAAATGGATGAAAACAGATTTGTGGCAGTTACCAGCACA
AATGCAGCCAAAATTTTTAATCTCTATCCAAGAAAAGGAAGAATAGCTGTAGGATCAGAT
GCTGACATTGTTATTTGGGACCCAAAAGGCACAAGGACTATCTCAGCAAAAACTCATCAT
CAGGCTGTTAACTTCAACATTTTCGAGGGCATGGTTTGCCACGGGGTGCCCCTTGTGACT
ATTTCAAGAGGCAAAGTGGTATATGAAGCCGGAGTGTTCAGTGTCACGGCAGGAGATGGG
AAGTTTATTCCTCGAAAACCATTTGCTGAATATATTTACAAACGAATAAAGCAGCGAGAC
CGGACTTGCACACCTACCCCTGTGGAGCGTGCACCCTATAAGGGAGAAGTCGCCACACTG
AAATCCAGAGTGACAAAAGAAGATGCCACAGCAGGGACCAGGAAACAGGCCCACCCCTGA


# Metabolic_Enzyme_1_GenBank_ID_Gene:
D78011

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_1_Locus:
8q22

# Metabolic_Enzyme_1_SNPs:
rs7825427; rs2298840; rs35013010; rs2853149; rs2853161; rs2246815; rs2333874; rs2669435; rs2246650; rs2669432; rs870789; rs2853150; rs2853178; rs2853169; rs2853164; rs2669429; rs1317472; rs2669436; rs1317380; rs1319371; rs2333871; rs2251371; rs2853168; rs1325; rs2853158; rs2853155; rs2853160; rs13263121; rs11783979; rs2853151; rs7821992; rs2853181; rs6468929; rs3737535; rs6468928; rs6999483; rs3793358; rs7000266; rs1513025; rs6989588; rs4734106; rs4305867; rs6468924; rs7004911; rs2669438; rs6989484; rs7012764; rs2853170; rs1513026; rs2246827; rs6994920; rs4734793; rs2853154; rs6468927; rs11989338; rs11779762; rs2853167; rs3133279; rs2250601; rs3793354; rs2853157; rs3793356; rs2853176; rs11995044; rs10505058; rs2853180; rs17245950; rs6989353; rs4734794; rs7014456; rs2853159; rs2853174; rs16871364; rs7012566; rs2669434; rs3793355; rs12675680; rs2669425; rs6468926; rs1962267; rs12679642; rs12545205; rs6994791; rs2669431; rs3793352; rs3793357; rs6983974; rs2669421; rs11987822; rs3133278; rs2853175; rs2253336; rs7010772; rs2853173; rs3793351; rs2853172; rs2669420; rs13271902; rs2669427; rs2669426; rs16871363; rs16871365; rs3793361; rs13249169; rs10808391; rs1327; rs4236774; rs2853156; rs2669430; rs2246821; rs16892397; rs13256669; rs1317357; rs13276697; rs2669437; rs6998185; rs13282328; rs10110355; rs2254738; rs13264598; rs2669419; rs16871466; rs3793353; rs4734797; rs7014134; rs10103147; rs2280010; rs7816369; rs17834440; rs6984745; rs2669423; rs13272770; rs3133281; rs2333875; rs12548603; rs3838708; rs2853179; rs4734798; rs17245780; rs2669424; rs2669433; rs7830021; rs4734796; rs2251374; rs1355691; rs16871361; rs16892398; rs6997991; rs2959024; rs2853148; rs2959025; rs36027551; rs34895123; rs35670436; rs35371065; rs2959023; rs6468925; rs6981049; rs11291771; rs34363633; rs36043601; rs35130488; rs35179334; rs5893687; rs34804847; rs34835869; rs34900729; rs3039791; rs3133280; rs34353212; rs1962266; rs34752863; rs35698680; rs13282051; rs17245479; rs34714020; rs34101301; rs34571719; rs33942215; rs35916478; rs34084483; rs35633624; rs7844185; rs35400656; rs11323937; rs35787438; rs2669439; rs2333870; rs28571799; rs35879325; rs35854847; rs10680569; rs28465605; rs4282534; rs35034310; rs35294948; rs35514435; rs10662772; rs5893685; rs11988300; rs1849444; rs35035392; rs35556854; rs34744515; rs2333873; rs36048718; rs2298841; rs35513452; rs35953220; rs2175692; rs35758944; rs13258070; rs10086232; rs5893688; rs7462383; rs13270458; rs34960309; rs34272796; rs34765621; rs11323938; rs2853152; rs35148727; rs35796122; rs35852759; rs35907176; rs1044403; rs35549842; rs2853162; rs34531171; rs2853171; rs7008591; rs34183780; rs2853130; rs34505030; rs13250630; rs35237634; rs3793360; rs6984037; rs11781253; rs7001837; rs28541850; rs11388669; rs35012619; rs34256594; rs4281090; rs35378953; rs3838709; rs28410924; rs35450967; rs7008920; rs34793099; rs1319386; rs2333872; rs2669428; rs2853163; rs13253383; rs34867904; rs11325699; rs35082298; rs5893686; rs35144447; rs34793262; rs3793359; rs36003516; rs36075709; rs3763515; rs34184625; rs28407196; rs34513404; rs10101743; rs1105622; rs11779233; rs11782457; rs11997948; rs12541941; rs12543989; rs1316456; rs1317221; rs1355692; rs2669440; rs2853135; rs2853136; rs2853138; rs2853139; rs2853140; rs2853141; rs2853142; rs2853143; rs2853144; rs2853145; rs2942570; rs2959026; rs2959027; rs35349928; rs3750187; rs4734787; rs4734788; rs4734790; rs6992445

# Metabolic_Enzyme_1_General_References:
8973361; 9718352

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5815

# Metabolic_Enzyme_2_Name:
Beta-ureidopropionase

# Metabolic_Enzyme_2_Synonyms:
Beta-alanine synthase; N- carbamoyl-beta-alanine amidohydrolase; BUP-1

# Metabolic_Enzyme_2_Gene_Name:
UPB1

# Metabolic_Enzyme_2_Protein_Sequence:
>Betaureidopropionase
MAGAEWKSLEECLEKHLPLPDLQEVKRVLYGKELRKLDLPREAFEAASREDFELQGYAFE
AAEEQLRRPR
IVHVGLVQNRIPLPANAPVAEQVSALHRRIKAIVEVAAMCGVNIICFQE
AWTMPFAFCTREKLPWTEFAE
SAEDGPTTRFCQKLAKNHDMVVVSPILERDSEHGDVLW
NTAVVISNSGAVLGKTRKNHIPRVGDFNESTY
YMEGNLGHPVFQTQFGRIAVNICYGRH
HPLNWLMYSINGAEIIFNPSATIGALSESLWPIEARNAAIANH
CFTCAINRVGTEHFPN
EFTSGDGKKAHQDFGYFYGSSYVAAPDSSRTPGLSRSRDGLLVAKLDLNLCQQV
NDVWN
FKMTGRYEMYARELAEAVKSNYSPTIVKE

# Metabolic_Enzyme_2_Number_of_Residues:
384

# Metabolic_Enzyme_2_Molecular_Weight:
43166

# Metabolic_Enzyme_2_Theoretical_pI:
6.51

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  nitrogen compound metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Converts N-carbamyl-beta-aminoisobutyric acid and N- carbamyl-beta-alanine to, respectively, beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide

# Metabolic_Enzyme_2_Pathway:
map00240  Pyrimidine metabolism;
 map00410  beta-Alanine metabolism;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_2_Reaction:
N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00795:CN_hydrolase

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.5.1.6

# Metabolic_Enzyme_2_GenBank_ID_Protein:
6288771

# Metabolic_Enzyme_2_SwissProt_ID:
BUP1_HUMAN (Q9UBR1)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
UPB1

# Metabolic_Enzyme_2_Geneatlas_id:
UPB1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:16297

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1155 bp

ATGGCGGGCGCTGAGTGGAAGTCGCTGGAGGAATGCTTGGAGAAGCACCTGCCGCTCCC
CGACTTGCAGG
AAGTGAAGCGCGTTCTCTATGGCAAGGAACTCAGGAAGCTTGATCTGC
CCAGGGAAGCTTTCGAAGCTGC
CTCCAGAGAAGACTTTGAACTGCAGGGATATGCCTTT
GAAGCAGCGGAGGAGCAGCTGAGACGACCCCGC
ATTGTGCACGTGGGGCTGGTTCAGAA
CAGAATCCCCCTCCCCGCAAATGCCCCTGTGGCAGAACAGGTCT
CTGCCCTTCATAGAC
GCATAAAGGCTATCGTAGAGGTGGCTGCAATGTGTGGAGTCAACATCATCTGTTT
CCAG
GAAGCATGGACTATGCCCTTTGCCTTCTGTACGAGAGAGAAGCTTCCTTGGACAGAATTT
GCTGAG
TCAGCAGAGGATGGGCCCACCACCAGATTCTGTCAGAAGCTGGCGAAGAACCA
TGACATGGTGGTGGTGT
CTCCCATCCTGGAACGAGACAGCGAGCATGGGGATGTTTTGT
GGAATACAGCCGTGGTGATCTCCAATTC
CGGAGCAGTCCTGGGAAAGACCAGGAAAAAC
CACATCCCCAGAGTGGGTGATTTCAACGAGTCAACTTAC
TACATGGAGGGAAACCTGGG
CCACCCCGTGTTCCAGACGCAGTTCGGAAGGATCGCGGTGAACATTTGCT
ACGGGCGGC
ACCACCCCCTCAACTGGCTTATGTACAGCATCAACGGGGCTGAGATCATCTTCAACCCCT
C
GGCCACGATAGGAGCACTCAGCGAGTCCCTGTGGCCCATCGAGGCCAGAAACGCAGCC
ATTGCCAATCAC
TGCTTCACCTGCGCCATCAATCGAGTGGGCACCGAGCACTTCCCGAA
CGAGTTTACCTCGGGAGATGGAA
AGAAAGCTCACCAGGACTTTGGCTACTTTTATGGCT
CGAGCTATGTGGCAGCCCCTGACAGCAGCCGGAC
TCCTGGGCTGTCCCGTAGCCGGGAT
GGACTGCTAGTTGCTAAGCTCGACCTAAACCTCTGCCAGCAGGTG
AATGATGTCTGGAA
CTTCAAGATGACGGGCAGGTATGAGATGTACGCACGGGAGCTCGCCGAAGCTGTCA
AGT
CCAACTACAGCCCCACCATCGTGAAAGAGTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF163312

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_2_Locus:
22q11.2

# Metabolic_Enzyme_2_SNPs:
rs34110964; rs2232867; rs1314; rs2070474; rs2232866; rs140330; rs6004171; rs1892721; rs2232868; rs738814; rs1015011; rs140324; rs5760464; rs140338; rs6004175; rs5996713; rs762279; rs8142051; rs140335; rs3788372; rs12159862; rs3788369; rs140337; rs131455; rs2298384; rs5760455; rs131456; rs1015050; rs12628029; rs6004167; rs5760467; rs175766; rs5996712; rs140334; rs4414772; rs35270298; rs2298385; rs3788370; rs5751894; rs9612646; rs3788371; rs8141985; rs5751893; rs140331; rs8139394; rs11912222; rs5760466; rs7290860; rs5760459; rs11704820; rs16978612; rs140332; rs2232865; rs6004174; rs5751892; rs7289159; rs2070473; rs34035085; rs9620392; rs2232870; rs35916595; rs2070475; rs34595756; rs33939150; rs6004176; rs175767; rs9608293; rs13055831; rs5760465; rs5760457; rs34272823; rs34212925; rs11704528; rs140339; rs5760461; rs5751891; rs9620394; rs34817009; rs35770800; rs5760458; rs5844593; rs9624489; rs131454; rs10428056; rs10427702; rs6004172; rs5760460; rs7290073; rs140326; rs12170801; rs41446544; rs11306738; rs8139687; rs35821245; rs140329; rs11912437; rs11704936; rs28588566; rs9612641; rs12159402; rs9624487; rs5751890; rs5996709; rs28793636; rs35606558; rs34346301; rs5760463; rs12168497; rs35350082; rs6004168; rs140327; rs5996711; rs34804666; rs12166299; rs140325; rs13056366; rs12170842; rs140328; rs131452; rs6004173; rs8137394; rs9624485; rs9624488; rs34688005; rs9624486; rs9612637; rs12159199; rs9608291; rs140333; rs10427760; rs5996710; rs12169955; rs2232864; rs6004169; rs3765615; rs11350644; rs140336; rs3032747; rs34577100; rs13056367; rs9624484; rs6004170; rs2232869; rs9612640; rs28461476; rs7289603; rs5760462; rs131453; rs4049935; rs34276962; rs5760456; rs11913979; rs9612643; rs34916208; rs34067128; rs41302573; rs2232863; rs2232862; rs2232858; rs2232860; rs5751889; rs7289016; rs2232861; rs2232859; rs2232857; rs11090327; rs131460; rs140342; rs1543757; rs17004940; rs4346492; rs4558681; rs4820592; rs4822501; rs4822502; rs5760449; rs5760450; rs5760451; rs5760452; rs5760469; rs5996707; rs5996715; rs9612648

# Metabolic_Enzyme_2_General_References:
10542323; 11508704

# Metabolic_Enzyme_2_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8498

# Macromolecular_Interacting_Partner_1_Name:
Dihydropyrimidinase-related protein 3

# Macromolecular_Interacting_Partner_1_Synonyms:
DRP-3; Unc-33-like phosphoprotein; ULIP protein; Collapsin response mediator protein 4; CRMP-4

# Macromolecular_Interacting_Partner_1_Gene_Name:
DPYSL3

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Dihydropyrimidinaserelated protein 3
MSYQGKKNIPRITSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEA
NGKMVIPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAY
EKWREWADGKSCCDYALHVDITHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTE
LYEIFTCLGELGAIAQVHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAI
TIASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAA
FVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEE
RMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKIV
SAKNHQSAAEYNIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYK
RIKARRKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSARGSPTRPNPPVRNLHQSGFSL
SGTQVDEGVRSASKRIVAPPGGRSNITSLS

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
570

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
61964

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.45

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Nucleotide transport and metabolism

# Macromolecular_Interacting_Partner_1_Specific_Function:
May regulate vesicle function in the growth cone

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01979:Amidohydro_1

# Macromolecular_Interacting_Partner_1_Signals:
Not Available

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
1330242

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
DPYL3_HUMAN (Q14195)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
DPYSL3

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
DPYSL3

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:3015

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cytoplasm. Cell projection; growth cone (By similarity). Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone (By similarity)

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1713 bp
ATGTCCTACCAAGGCAAGAAGAACATCCCGCGGATCACGAGTGACCGTCTCCTTATCAAG
GGAGGCAGAATCGTCAATGATGATCAGTCCTTTTATGCTGATATTTACATGGAAGATGGC
TTAATAAAACAAATTGGAGACAATCTGATTGTTCCTGGAGGAGTGAAGACCATTGAAGCC
AATGGGAAGATGGTGATCCCTGGAGGCATCGATGTCCATACTCACTTCCAGATGCCATAT
AAGGGAATGACCACAGTAGATGACTTCTTCCAAGGGACAAAGGCGGCCTTAGCAGGTGGC
ACCACCATGATCATTGACCATGTGGTGCCTGAGCCTGAGTCCAGCCTGACTGAGGCCTAT
GAGAAATGGAGAGAGTGGGCTGATGGGAAGAGTTGCTGTGACTATGCCCTGCATGTGGAC
ATCACCCACTGGAATGACAGCGTCAAGCAGGAAGTGCAGAACCTCATCAAGGACAAAGGG
GTTAACTCCTTCATGGTTTATATGGCTTATAAGGATTTGTATCAAGTATCTAACACAGAG
CTCTATGAGATCTTCACCTGCCTGGGAGAGCTGGGGGCCATTGCTCAAGTTCATGCTGAG
AATGGGGATATCATTGCCCAGGAGCAAACCCGCATGTTGGAAATGGGGATAACTGGCCCA
GAAGGCCATGTACTGAGCAGGCCAGAAGAGCTGGAAGCTGAGGCTGTGTTCCGTGCCATC
ACCATTGCCAGCCAAACCAATTGCCCTCTCTACGTCACAAAGGTCATGAGCAAGAGTGCA
GCTGACCTCATCTCACAAGCCAGGAAAAAAGGAAATGTAGTCTTTGGTGAGCCCATCACT
GCCAGCCTCGGCATAGATGGAACCCATTATTGGAGCAAGAACTGGGCCAAGGCGGCTGCA
TTTGTGACATCCCCACCCCTGAGCCCTGACCCAACTACTCCGGACTACATCAACTCCTTG
CTGGCCAGCGGGGATCTGCAGCTATCTGGGAGTGCCCACTGCACCTTCAGCACTGCCCAG
AAAGCAATTGGGAAGGACAACTTCACAGCCATTCCTGAGGGCACCAATGGTGTGGAGGAG
CGGATGTCTGTCATCTGGGACAAGGCTGTGGCCACAGGGAAAATGGACGAAAACCAGTTC
GTGGCTGTGACAAGCACAAACGCTGCCAAGATCTTCAACCTGTATCCCCGCAAGGGAAGA
ATATCTGTGGGTTCTGACAGCGACCTCGTCATCTGGGATCCAGATGCTGTGAAGATCGTC
TCTGCCAAGAACCACCAGTCTGCGGCAGAGTACAACATCTTTGAAGGGATGGAGCTGCGC
GGGGCTCCTCTGGTTGTCATCTGCCAGGGCAAGATCATGCTGGAAGATGGCAACCTGCAC
GTGACCCAGGGGGCTGGCCGCTTCATACCCTGCAGCCCGTTCTCCGACTATGTCTACAAG
CGCATTAAAGCACGGAGGAAGATGGCAGACCTGCATGCCGTCCCAAGGGGCATGTACGAT
GGGCCTGTGTTTGACCTGACCACCACCCCCAAAGGTGGCACCCCCGCAGGCTCTGCTCGG
GGCTCTCCTACTCGGCCGAACCCACCTGTGAGGAATCTTCATCAGTCGGGATTTAGCCTG
TCAGGCACCCAAGTGGATGAGGGGGTTCGCTCAGCCAGCAAGCGCATCGTGGCCCCCCCA
GGCGGCCGTTCTAATATCACATCTCTGAGTTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
D78014

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_1_Locus:
5q32

# Macromolecular_Interacting_Partner_1_SNPs:
rs2304044; rs10515587; rs3792837; rs17106709; rs1049171; rs3805533; rs11950394; rs13495; rs3749721; rs10065495; rs2288806; rs2304045; rs1432836; rs1432856; rs2288807; rs2163767; rs1432855; rs6886313; rs6877057; rs3792846; rs6892646; rs3792840; rs7732327; rs3213856; rs4705168; rs10079318; rs1432857; rs3792839; rs2288808; rs12515377; rs3805534; rs2288800; rs12657083; rs4705171; rs1432854; rs995976; rs7716469; rs7700678; rs6891468; rs2241696; rs7720075; rs7737514; rs2278381; rs7730192; rs7725771; rs6897123; rs2288804; rs12657176; rs1864961; rs10056132; rs1432853; rs11955404; rs7737495; rs12514302; rs12653560; rs7725904; rs3816013; rs17484444; rs11960053; rs11952079; rs17096661; rs11167990; rs17550470; rs1864962; rs6580463; rs17106725; rs3213857; rs17106726; rs17106713; rs6887761; rs12657809; rs3805538; rs2288803; rs3805536; rs11953018; rs12655364; rs17106698; rs3816012; rs7713047; rs1432852; rs2288805; rs7737670; rs17106658; rs4705169; rs17550902; rs7720384; rs11738709; rs10052013; rs6866421; rs1030664; rs2288802; rs11952440; rs6861479; rs11950421; rs10059782; rs4705172; rs3805535; rs2304046; rs10045916; rs6873278; rs11738683; rs3805539; rs3213858; rs6867744; rs17106761; rs17106743; rs12655492; rs12515730; rs17106723; rs3805546; rs9885115; rs12518292; rs17106691; rs3805544; rs17106683; rs3792844; rs6877045; rs17106688; rs7710577; rs17106716; rs13168262; rs1121657; rs13340333; rs11958380; rs17106746; rs17106686; rs3805545; rs6899104; rs1549915; rs17106689; rs3792841; rs3805543; rs17106682; rs2078128; rs11948890; rs3792845; rs3805540; rs17106701; rs2304043; rs17106690; rs3792843; rs2288809; rs17106679; rs6879557; rs3805542; rs10043932; rs891947; rs7700723; rs7728665; rs7714137; rs10064194; rs4642416; rs12513884; rs2895681; rs17106620; rs17106765; rs1803521; rs17853869; rs17853868; rs35891125; rs34332356; rs35381274; rs3805532; rs13002; rs35067518; rs1049161; rs6897295; rs1049378; rs1803520; rs34094540; rs13340338; rs7736691; rs36084531; rs10041249; rs3792842; rs36051157; rs34055088; rs28682302; rs35488909; rs10649833; rs13169665; rs4705170; rs10553344; rs2288801; rs41291407; rs35070418; rs34173457; rs11383280; rs34195078; rs41291405; rs35504293; rs11463979; rs35272843; rs34784063; rs6875205; rs1529689; rs34222194; rs10042993; rs3213855; rs10561142; rs34893040; rs2116776; rs9686079; rs35309287; rs34943516; rs35739037; rs5872019; rs2304047; rs13153310; rs41291409; rs35906615; rs35959663; rs10463275; rs35508159; rs34575049; rs3838662; rs11438535; rs4492158; rs13172668; rs3828640; rs10561140; rs34164945; rs13340366; rs3805537; rs3995474; rs35222650; rs10649832; rs11743139; rs28691592; rs34398961; rs36023679; rs35323408; rs6892354; rs9686962; rs36172751; rs13436842; rs35998040; rs35058477; rs10561141; rs34527322; rs35591026; rs34720144; rs10072652; rs10476887; rs10515586; rs11167989; rs1158445; rs11950567; rs12655505; rs1432837; rs1432838; rs17106606; rs17106607; rs17106610; rs1897563; rs729530; rs744585; rs7714240; rs972302

# Macromolecular_Interacting_Partner_1_General_References:
8973361; 9115293

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8721

# Macromolecular_Interacting_Partner_2_Name:
Dihydropyrimidinase-related protein 2

# Macromolecular_Interacting_Partner_2_Synonyms:
DRP-2; Collapsin response mediator protein 2; CRMP-2; N2A3

# Macromolecular_Interacting_Partner_2_Gene_Name:
DPYSL2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Dihydropyrimidinaserelated protein 2
MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEA
HSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAF
DQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQ
IYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAI
TIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAA
FVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEE
RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI
SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYK
RIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFS
LSGAQIDDNIPRRTTQRIVAPPGGRANITSLG

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
572

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
62294

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.33

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Nucleotide transport and metabolism

# Macromolecular_Interacting_Partner_2_Specific_Function:
Involved in neuronal growth cone collapse. Induces axon formation

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF01979:Amidohydro_1

# Macromolecular_Interacting_Partner_2_Signals:
Not Available

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
1244400

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
DPYL2_HUMAN (Q16555)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
DPYSL2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
DPYSL2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:3014

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cytoplasm (Potential)

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1719 bp
ATGTCTTATCAGGGGAAGAAAAATATTCCACGCATCACGAGCGATCGTCTTCTGATCAAA
GGAGGTAAAATTGTTAATGATGACCAGTCGTTCTATGCAGACATATACATGGAAGATGGG
TTGATCAAGCAAATAGGAGAAAATCTGATTGTGCCAGGAGGAGTGAAGACCATCGAGGCC
CACTCCCGGATGGTGATCCCCGGAGGAATTGACGTCCACACTCGTTTCCAGATGCCTGAT
CAGGGAATGACGTCTGCTGATGATTTCTTCCAAGGAACCAAGGCGGCCCTGGCTGGGGGA
ACCACTATGATCATTGACCACGTTGTTCCTGAGCCTGGGACAAGCCTGCTCGCTGCCTTT
GACCAGTGGAGGGAATGGGCCGACAGCAAGTCCTGCTGTGACTACTCTCTGCATGTGGAC
ATCAGCGAGTGGCATAAGGGCATCCAGGAGGAGATGGAAGCGCTTGTGAAGGATCACGGG
GTAAATTCCTTCCTCGTGTACATGGCTTTCAAAGATCGCTTCCAGCTAACGGATTGCCAG
ATTTATGAAGTACTGAGTGTGATCCGGGATATTGGCGCCATAGCCCAAGTCCACGCAGAA
AATGGCGACATCATTGCAGAGGAGCAGCAGAGGATCCTGGATCTGGGCATCACGGGCCCC
GAGGGACATGTGCTGAGCCGACCTGAGGAGGTCGAGGCCGAAGCCGTGAATCGTGCCATC
ACCATCGCCAACCAGACCAACTGCCCGCTGTATATCACCAAGGTGATGAGCAAAAGCTCT
GCTGAGGTCATCGCCCAGGCACGGAAGAAGGGAACTGTGGTGTATGGCGAGCCCATCACT
GCCAGCTTGGGAACGGACGGCTCCCATTACTGGAGCAAGAACTGGGCCAAGGCTGCTGCC
TTTGTCACCTCCCCACCCTTGAGCCCTGATCCAACCACTCCAGACTTTCTCAACTCCTTG
CTGTCCTGTGGAGACCTCCAGGTCACGGGCAGTGCCCATTGCACGTTTAACACTGCCCAG
AAGGCTGTAGGAAAGGACAACTTCACCCTGATTCCGGAGGGCACCAATGGCACTGAGGAG
CGGATGTCCGTCATCTGGGACAAGGCTGTGGTCACTGGGAAGATGGATGAGAACCAGTTT
GTGGCTGTGACCAGCACCAATGCAGCCAAAGTCTTCAACCTTTACCCCCGGAAAGGCCGC
ATTGCTGTGGGATCCGATGCCGACCTGGTCATCTGGGACCCCGACAGCGTTAAAACCATC
TCTGCCAAGACACACAACAGCTCTCTCGAGTACAACATCTTTGAAGGCATGGAGTGCCGC
GGCTCCCCACTGGTGGTCATCAGCCAGGGGAAGATTGTCCTGGAGGACGGCACCCTGCAT
GTCACCGAAGGCTCTGGACGCTACATTCCCCGGAAGCCCTTCCCTGATTTTGTTTACAAG
CGTATCAAGGCAAGGAGCAGGCTGGCTGAGCTGAGAGGGGTTCCTCGTGGCCTGTATGAC
GGACCCGTGTGTGAAGTGTCTGTGACGCCCAAGACAGTCACTCCAGCCTCCTCGGCCAAG
ACGTCTCCTGCCAAGCAGCAGGCCCCACCTGTCCGGAACCTGCACCAGTCTGGATTCAGT
TTGTCTGGTGCTCAGATTGATGACAACATTCCCCGCCGCACCACCCAGCGTATCGTGGCG
CCCCCCGGTGGCCGTGCCAACATCACCAGCCTGGGCTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
U17279

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:8

# Macromolecular_Interacting_Partner_2_Locus:
8p22-p21

# Macromolecular_Interacting_Partner_2_SNPs:
rs2289593; rs327222; rs11786691; rs708621; rs920633; rs11863; rs17666; rs1058332; rs10495; rs17055646; rs3739219; rs17055641; rs10042; rs327215; rs2585459; rs1992472; rs1972921; rs327225; rs894509; rs327224; rs749936; rs448872; rs930470; rs385351; rs920697; rs1867042; rs327218; rs388047; rs327234; rs1561818; rs6992095; rs452787; rs1662248; rs451164; rs327226; rs11135950; rs6557933; rs327233; rs7825468; rs327221; rs6557930; rs11135951; rs4872457; rs13271910; rs398008; rs7004868; rs2034040; rs7829347; rs7841384; rs2289592; rs10088957; rs376954; rs6557931; rs7834325; rs384908; rs7835006; rs6557929; rs7832234; rs182748; rs6988996; rs920632; rs2584187; rs408753; rs7011131; rs6990931; rs12234932; rs4733048; rs749937; rs327223; rs920631; rs327230; rs7820433; rs327232; rs7840494; rs4733044; rs5022821; rs9644116; rs11995227; rs17322303; rs7812694; rs753508; rs327229; rs17322324; rs6557927; rs12678418; rs429591; rs17055516; rs17055593; rs11775462; rs17322275; rs17321828; rs12541748; rs4733033; rs11782869; rs11775497; rs17055515; rs999772; rs13277175; rs17322640; rs6557928; rs12677999; rs749935; rs9644117; rs4478581; rs17322528; rs4733013; rs327237; rs17322366; rs11776975; rs11775862; rs17055486; rs11774146; rs17405591; rs10093591; rs11776801; rs5029306; rs327227; rs7001738; rs1442336; rs327217; rs11780026; rs9644118; rs17406372; rs17055585; rs17405668; rs12550663; rs2585457; rs7832576; rs12677981; rs13250931; rs4076071; rs5022822; rs13249892; rs753509; rs429787; rs7818193; rs11778165; rs2083739; rs4732714; rs415524; rs17055546; rs11783896; rs12541952; rs17055500; rs12549410; rs403185; rs11775967; rs17055504; rs2120049; rs17055487; rs11775859; rs12546827; rs12546828; rs1808892; rs17322408; rs17321041; rs17055489; rs327228; rs11781865; rs12545134; rs327216; rs17322051; rs11780034; rs17088245; rs17419937; rs11990271; rs379266; rs17055482; rs17055494; rs7845756; rs7816762; rs17055502; rs17055605; rs2585458; rs10441614; rs7015088; rs17055514; rs7460917; rs327236; rs7008546; rs17055492; rs11780147; rs2322130; rs11784967; rs11781198; rs7009085; rs17055537; rs17055582; rs17055480; rs327214; rs327235; rs17055521; rs13249543; rs6557932; rs17055536; rs13260473; rs371255; rs3808564; rs6988457; rs6557926; rs17055491; rs11995685; rs6998628; rs6983262; rs7827731; rs7828056; rs2585456; rs445678; rs400181; rs367948; rs35621323; rs4733059; rs34588307; rs1803519; rs35258691; rs11527; rs34335048; rs17055639; rs3837184; rs1058457; rs41276289; rs34673092; rs35314544; rs1058333; rs1058313; rs11399423; rs35690946; rs28470992; rs34792838; rs34382438; rs6982026; rs390323; rs41276287; rs41276285; rs399788; rs34226529; rs34238466; rs920630; rs167855; rs34978863; rs28649929; rs34204302; rs2584183; rs35446474; rs3074034; rs34051886; rs35134585; rs34375962; rs10691983; rs35587383; rs2584182; rs35321818; rs11427313; rs35493897; rs920695; rs11400209; rs10584379; rs35273847; rs34633365; rs13262574; rs11998448; rs35225449; rs35476823; rs35253282; rs7010042; rs13248890; rs2584184; rs2120048; rs10556349; rs28889579; rs35219984; rs7015859; rs28750171; rs13276391; rs3074029; rs35474814; rs35226523; rs327213; rs34151191; rs7828110; rs33993906; rs11399087; rs11786298; rs11384905; rs3926189; rs12542360; rs36063450; rs7002026; rs17055594; rs327220; rs34880068; rs36110958; rs3779913; rs34241661; rs35006006; rs35117658; rs327231; rs10690987; rs35491396; rs33963820; rs36177037; rs4055147; rs11383598; rs35692875; rs28498128; rs11287159; rs1442337; rs34321710; rs7017875; rs35004176; rs35696405; rs4733051; rs7014178; rs2584185; rs35346128; rs35539107; rs34007808; rs7820494; rs35258351; rs35498265; rs11427312; rs35717375; rs10690986; rs11357827; rs35866474; rs35153261; rs41432246; rs7821827; rs378278; rs11285674; rs35363743; rs1966766; rs11355802; rs10606826; rs431246; rs3840708; rs17088240; rs11774816; rs11778187; rs11784283; rs11786284; rs11993953; rs12155555; rs13249662; rs13258612; rs13259621; rs13275466; rs17055673; rs17088247; rs17088251; rs17320101; rs17320156; rs17330335; rs2584188; rs2585455; rs364508; rs380423; rs401004; rs408157; rs418624; rs424422; rs429020; rs431217; rs442103; rs6557935; rs6987195; rs6987220; rs7827953; rs7831883; rs7842128; rs7845740; rs894330; rs920696; rs9644119

# Macromolecular_Interacting_Partner_2_General_References:
7637782; 8973361; 10574455; 10757975

# Macromolecular_Interacting_Partner_2_References:
Not Available

End of HMDB00026

Beginning of HMDB00027
# Accession_No:
HMDB00027

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-12 16:13:55

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Tetrahydrobiopterin

# Description:
Tetrahydrobiopterin or BH4 is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase. A defect in BH4 production and/or a defect in the enzyme dihydropteridine reductase (DHPR) causes phenylketonuria type IV, as well as dopa-responsive dystonias. -- Wikipedia.  

# Synonyms:
(1R,2S)-(2-Amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)-1,2-propandiol; 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)-5,6,7,8-Tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone; 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-Pteridinone; 5,6,7,8-Tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone; 5,6,7,8-Tetrahydrobiopterin; 5,6,7,8-erythro-tetrahydrobiopterin; 5,6,7,8-tetra-H-biopterin; L-erythro-2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(3H)-pteridinon; Tetrahydrobiopterin; tetra-H-biopterin; tetra-hydro-biopterin

# Chemical_IUPAC_Name:
2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-1H-pteridin-4-one

# Chemical_Formula:
C9H15N5O3

# Chemical_Structure:
tbl_chemical:::HMDB00027_ZOOM.png:::119283139231966374

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00027_THUMB.png:::119283139033785907

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Vitamins; Pterins

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
secondary alcohol; 1,2-diol; 1,2-aminoalcohol; primary amine; primary aromatic amine; secondary amine; secondary aliphatic/aromatic amine (alkylarylamine); oxo(het)arene; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Enzyme co-factor; Component of Phenylalanine, tyrosine and tryptophan biosynthesis; Component of Tryptophan metabolism; Component of Tyrosine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
241.11749

# Molecular_Weight_Avg:
241.24710

# Smiles_String_isomeric:
CC(O)C(O)C1CNC2=C(N1)C(=O)NC(N)=N2

# Smiles_String_canonical:
CC(O)C(O)C1CNC2=C(N1)C(=O)NC(N)=N2

# KEGG_Compound_ID:
C00272

# BioCyc_ID:
TETRA-H-BIOPTERIN

# PubChem_CID:
1125

# PubChem_SID:
3570; 5642916; 7365597; 8150986; 207223; 3210; 8143160

# OMIM_ID:
126060; 182125; 233910; 261630; 261640; 264070

# Metagene_ID:
Not Available

# BiGG_ID:
34464

# Wikipedia_ID:
Tetrahydrobiopterin

# METLIN_ID:
5098

# Ref_ID:
11573638; 14500751; 3536512; 11416883; 12891653; 932231; 11168813; 3939528; 16165391; 12971421; 7869898; 16033258; 3888618; 9667588; 6139056; 11486900

# ChEBI_ID:
15372

# CAS_Registry_Number:
17528-72-2

# InChI:
InChI=1/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)

# Synthesis_Reference:
Not Available

# Melting_Point:
250-255 oC (hydrochloride salt)

# Melting_Point_predicted:
132.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
2.03 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-1.82 [Predicted by ALOGPS]; -1.7 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00272.mol:::1132723802187504536

# SDF_File_[Text]:
tbl_chemical:::HMDB00027.sdf:::119283138562730381

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00027.pdb:::119283138866196305

# PDB_ID:
1DF1

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1DF1.txt:::113272089896859924

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::5,6,7,8-Tetrahydrobiopterin.gif:::1132732100078758123

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00027_peaks.txt:::1156309495564847060

# Predicted_C_NMR_Spectrum:
tbl_chemical:::5,6,7,8-Tetrahydrobiopterin_C.gif:::1132737660522595907

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00027_peaks.txt:::1156310687395293200

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP); nucleus

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF

# Concentration_[Normal]:
Blood	2 (0-4)	uM	Adult:>18_yrs_old	Both	Normal	11573638


# Concentration_[Abnormal]:
Cerebrospinal_Fluid(CSF)	14400.0	umol/L	Newborn:0-30_days_old	Both	Seizures	7869898


# Associated_Disorders:
Biopterin Deficiency; Neuroblastoma; Phenylketonuria III; Pheochromocytoma; Seizures; Septic Shock

# Pathway_Names:
Folate biosynthesis

# Pathway_Images:
Not Available

# KEGG_Images:
map00790

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5711

# Metabolic_Enzyme_1_Name:
Tryptophan 5-hydroxylase 2

# Metabolic_Enzyme_1_Synonyms:
Tryptophan 5-monooxygenase 2; Neuronal tryptophan hydroxylase

# Metabolic_Enzyme_1_Gene_Name:
TPH2

# Metabolic_Enzyme_1_Protein_Sequence:
>Tryptophan 5hydroxylase 2
MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATE
SGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFN
ELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHP
GFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYL
KNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQ
YIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFF
TIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYF
VSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDA
LNKMNQYLGI

# Metabolic_Enzyme_1_Number_of_Residues:
490

# Metabolic_Enzyme_1_Molecular_Weight:
56057

# Metabolic_Enzyme_1_Theoretical_pI:
6.36

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  tryptophan 5-monooxygenase activity
Function:  amine binding
Function:  amino acid binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  neurotransmitter metabolism
Process:  neurotransmitter biosynthesis
Process:  serotonin biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
L-tryptophan + tetrahydrobiopterin + O(2) = 5- hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_1_Pathway:
map00380  Tryptophan metabolism

# Metabolic_Enzyme_1_Reaction:
L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01842:ACT;
PF00351:Biopterin_H

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.14.16.4

# Metabolic_Enzyme_1_GenBank_ID_Protein:
27497159

# Metabolic_Enzyme_1_SwissProt_ID:
TPH2_HUMAN (Q8IWU9)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
TPH2

# Metabolic_Enzyme_1_Geneatlas_id:
TPH2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:20692

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1473 bp
ATGCAGCCAGCAATGATGATGTTTTCCAGTAAATACTGGGCACGGAGAGGGTTTTCCCTG
GATTCAGCAGTGCCCGAAGAGCATCAGCTACTTGGCAGCTCAACACTAAATAAACCTAAC
TCTGGCAAAAATGACGACAAAGGCAACAAGGGAAGCAGCAAACGTGAAGCTGCTACCGAA
AGTGGCAAGACAGCAGTTGTTTTCTCCTTGAAGAATGAAGTTGGTGGATTGGTAAAAGCA
CTGAGGCTCTTTCAGGAAAAACGTGTCAACATGGTTCATATTGAATCCAGGAAATCTCGG
CGAAGAAGTTCTGAGGTTGAAATCTTTGTGGACTGTGAGTGTGGGAAAACAGAATTCAAT
GAGCTCATTCAGTTGCTGAAATTTCAAACCACTATTGTGACGCTGAATCCTCCAGAGAAC
ATTTGGACAGAGGAAGAAGAGCTAGAGGATGTGCCCTGGTTCCCTCGGAAGATCTCTGAG
TTAGACAAATGCTCTCACAGAGTTCTCATGTATGGTTCTGAGCTTGATGCTGACCACCCA
GGATTTAAGGACAATGTCTATCGACAGAGAAGAAAGTATTTTGTGGATGTGGCCATGGGT
TATAAATATGGTCAGCCCATTCCCAGGGTGGAGTATACTGAAGAAGAAACTAAAACTTGG
GGTGTTGTATTCCGGGAGCTCTCCAAACTCTATCCCACTCATGCTTGCCGAGAGTATTTG
AAAAACTTCCCTCTGCTGACTAAATACTGTGGCTACAGAGAGGACAATGTGCCTCAACTC
GAAGATGTCTCCATGTTTCTGAAAGAAAGGTCTGGCTTCACGGTGAGGCCGGTGGCTGGA
TACCTGAGCCCACGAGACTTTCTGGCAGGACTGGCCTACAGAGTGTTCCACTGTACCCAG
TACATCCGGCATGGCTCAGATCCCCTCTACACCCCAGAACCAGACACATGCCATGAACTC
TTGGGACATGTTCCACTACTTGCGGATCCTAAGTTTGCTCAGTTTTCACAAGAAATAGGT
CTGGCGTCTCTGGGAGCATCAGATGAAGATGTTCAGAAACTAGCCACGTGCTATTTCTTC
ACAATCGAGTTTGGCCTTTGCAAGCAAGAAGGGCAACTGCGGGCATATGGAGCAGGACTC
CTTTCCTCCATTGGAGAATTAAAGCACGCCCTTTCTGACAAGGCATGTGTGAAAGCCTTT
GACCCAAAGACAACTTGCTTACAGGAATGCCTTATCACCACCTTCCAGGAAGCCTACTTT
GTTTCAGAAAGTTTTGAAGAAGCCAAAGAAAAGATGAGGGACTTTGCAAAGTCAATTACC
CGTCCCTTCTCAGTATACTTCAATCCCTACACACAGAGTATTGAAATTCTGAAAGACACC
AGAAGTATTGAAAATGTGGTGCAGGACCTTCGCAGCGACTTGAATACAGTGTGTGATGCT
TTAAACAAAATGAACCAATATCTGGGGATTTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AY098914

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_1_Locus:
12q21.1

# Metabolic_Enzyme_1_SNPs:
rs17110563; rs4290270; rs7305115; rs17110747; rs1386493; rs2129575; rs1386494; rs2220330; rs1843809; rs1386495; rs1487284; rs1352251; rs1386497; rs1007023; rs1386488; rs990234; rs1386496; rs1843812; rs1352250; rs7310090; rs4760747; rs4760750; rs1473473; rs1386483; rs7963720; rs6582080; rs6582073; rs10748187; rs1487278; rs6582078; rs12322900; rs4760754; rs6582074; rs1386489; rs1386486; rs4641528; rs10748186; rs10879352; rs10748185; rs1487279; rs10879345; rs7954332; rs10879348; rs1386482; rs3903502; rs4430554; rs2200579; rs1386485; rs4760817; rs7295981; rs11179039; rs10879350; rs1386492; rs7979770; rs10784947; rs7978692; rs10748188; rs7978482; rs9325202; rs6582081; rs10879354; rs4760816; rs7299582; rs12230512; rs4488237; rs11834114; rs10879351; rs7307319; rs7315855; rs4760815; rs10879355; rs12231731; rs11179018; rs1487280; rs1487276; rs4641527; rs11179049; rs11179001; rs10879357; rs4565946; rs7967686; rs1386490; rs11179065; rs10506646; rs10506647; rs10748190; rs2368049; rs6582077; rs11178999; rs17722134; rs10784944; rs10784942; rs11179002; rs4760748; rs1532008; rs12319219; rs11615016; rs7300490; rs4469933; rs11830353; rs11179023; rs4760753; rs4760818; rs11179051; rs7969114; rs11179047; rs11179050; rs10784941; rs10506645; rs10506648; rs1386491; rs10879358; rs12311278; rs11830135; rs2046582; rs1843811; rs7964252; rs10879344; rs7968346; rs7300641; rs10879353; rs10784943; rs11179066; rs17110540; rs12301662; rs11179027; rs4474484; rs7309686; rs10748189; rs11833554; rs4760749; rs10506644; rs1843810; rs11179003; rs11179033; rs17110536; rs7967586; rs7963226; rs7955501; rs10879346; rs11179052; rs11179000; rs11831550; rs17110627; rs1487281; rs1386498; rs2171363; rs4760755; rs12229394; rs1487275; rs17110690; rs12231341; rs11834097; rs1023990; rs12231356; rs7954568; rs11179044; rs7134722; rs11830147; rs7954758; rs11179063; rs10879347; rs11179056; rs11179032; rs11179007; rs11179046; rs4453277; rs4760820; rs2171364; rs11179064; rs17110566; rs10879349; rs11179017; rs17110477; rs7299528; rs7487961; rs17110741; rs4362185; rs11179031; rs17110532; rs4573728; rs10784946; rs12231408; rs11179041; rs10784945; rs6582076; rs12228278; rs4503586; rs17110507; rs7139179; rs990235; rs4362186; rs6582075; rs17110668; rs7967568; rs4573729; rs10879359; rs11179034; rs12228879; rs11179048; rs7962607; rs11179024; rs11179008; rs17110467; rs7954105; rs4760814; rs7977183; rs2171365; rs17840794; rs1017933; rs4341581; rs4531512; rs11835828; rs2367899; rs11179058; rs11179059; rs11179020; rs6582079; rs6582072; rs7954142; rs12321434; rs17110489; rs7139195; rs11179015; rs4760751; rs11179043; rs11179022; rs12230254; rs17110472; rs7300445; rs11179004; rs11179038; rs11179045; rs4570625; rs7963717; rs7963803; rs11178996; rs34115267; rs7488262; rs2887147; rs41317132; rs2887148; rs41317122; rs41317118; rs41317116; rs11178998; rs12813452; rs2632292; rs35993964; rs36102830; rs34100617; rs12831769; rs7350608; rs1487286; rs12312472; rs2046583; rs12831265; rs11179060; rs2632287; rs41265611; rs35367496; rs2450502; rs12831272; rs12314642; rs2008391; rs5799059; rs35958105; rs1487273; rs2450501; rs35035554; rs1023989; rs10716615; rs12302940; rs11179012; rs11179037; rs41317136; rs2468914; rs7304392; rs12814228; rs12296809; rs11179025; rs2468917; rs11179019; rs34378240; rs7298203; rs7958320; rs2468920; rs7315349; rs35794144; rs11179055; rs12812037; rs12228469; rs9738929; rs2632290; rs34599234; rs2632293; rs41317128; rs11829559; rs34046675; rs11179054; rs35124331; rs11316791; rs2129576; rs2632288; rs35446623; rs2732333; rs1005691; rs10550878; rs11179011; rs11330029; rs5799058; rs12814265; rs5799061; rs2450504; rs35402781; rs12821195; rs36018735; rs2931544; rs34856767; rs2632294; rs12228247; rs11385244; rs11462521; rs763541; rs34763587; rs34121208; rs34723664; rs2632291; rs4503587; rs17840795; rs34428545; rs35425528; rs35583269; rs12812852; rs2468922; rs2732329; rs34488392; rs11179036; rs41317124; rs4760752; rs11179053; rs34679573; rs5799057; rs2200580; rs35694485; rs35463818; rs11179014; rs35205883; rs41317134; rs35597435; rs1487274; rs2468916; rs12821199; rs6582082; rs7968971; rs34540665; rs11179016; rs12424793; rs11179062; rs2632289; rs12367924; rs2220329; rs34303765; rs41317120; rs5799060; rs10574609; rs35440773; rs12301107; rs12829796; rs2450503; rs36090475; rs12812015; rs11830809; rs12812513; rs2931545; rs11179010; rs11179005; rs12831748; rs2468921; rs2468919; rs35445127; rs34487536; rs2468915; rs2046584; rs9668942; rs34206155; rs35740727; rs12811510; rs11179009; rs11179013; rs36017866; rs34790266; rs1386484; rs41317126; rs2129574; rs34517220; rs2468918; rs11179029; rs34354367; rs34133267; rs12812196; rs34334884; rs34169600; rs41317130; rs11179057; rs35633991; rs11179006; rs10578769; rs11179061; rs11179028; rs12230557; rs41317114; rs41269717; rs41269713; rs11178997; rs41269707; rs41269715; rs41269709; rs41269711; rs41265615; rs41269719; rs11178991; rs11178992; rs11178993; rs11179068; rs12229424; rs12309337; rs12580063; rs1386487; rs17110443; rs17110451; rs17110459; rs1872824; rs2632286; rs2732330; rs2732331; rs2732332; rs3935748; rs4131348; rs4145228; rs4448731; rs4760813; rs6582071; rs6582083; rs7296397; rs7296838; rs7309440; rs7969998; rs901597

# Metabolic_Enzyme_1_General_References:
12511643

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5816

# Metabolic_Enzyme_2_Name:
Dihydropteridine reductase

# Metabolic_Enzyme_2_Synonyms:
HDHPR; Quinoid dihydropteridine reductase

# Metabolic_Enzyme_2_Gene_Name:
QDPR

# Metabolic_Enzyme_2_Protein_Sequence:
>Dihydropteridine reductase
MAAAAAAGEARRVLVYGGRGALGSRCVQAFRARNWWVASVDVVENEEASASIIVKMTDSF
TEQADQVTAEVGKLLGEEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSH
LATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAV
LPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGKNRPSSGSLIQVVTTEGRTELT
PAYF

# Metabolic_Enzyme_2_Number_of_Residues:
244

# Metabolic_Enzyme_2_Molecular_Weight:
25790

# Metabolic_Enzyme_2_Theoretical_pI:
7.45

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases

# Metabolic_Enzyme_2_Pathway:
map00790  Folate biosynthesis

# Metabolic_Enzyme_2_Reaction:
a 5,6,7,8-tetrahydropteridine + NAD(P)+ = a 6,7-dihydropteridine + NAD(P)H + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.5.1.34

# Metabolic_Enzyme_2_GenBank_ID_Protein:
30819

# Metabolic_Enzyme_2_SwissProt_ID:
DHPR_HUMAN (P09417)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
QDPR

# Metabolic_Enzyme_2_Geneatlas_id:
QDPR

# Metabolic_Enzyme_2_hgnc_id:
HGNC:9752

# Metabolic_Enzyme_2_PDB_ID:
1HDR

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>735 bp
ATGGCGGCGGCGGCGGCTGCAGGCGAGGCGCGCCGGGTGCTGGTGTACGGCGGCAGGGGC
GCTCTGGGTTCTCGATGCGTGCAGGCTTTTCGGGCCCGCAACTGGTGGGTTGCCAGCGTT
GATGTGGTGGAGAATGAAGAGGCCAGCGCTACGATCATTGTTAAAATGACAGACTCGTTC
ACTGAGCAGGCTGACCAGGTGACTGCTGAGGTTGGAAAGCTCTTGGGTGAAGAGAAGGTG
GATGCAATTCTTTGCGTTGCTGGAGGATGGGCCGGGGGCAATGCCAAATCCAAGTCTCTC
TTTAAGAACTGTGACCTGATGTGGAAGCAGAGCATATGGACATCGACCATCTCCAGCCAT
CTGGCTACCAAGCATCTCAAGGAAGGAGGCCTCCTGACCTTGGCTGGCGCAAAGGCTGCC
CTGGATGGGACTCCTGGTATGATCGGGTACGGCATGGCCAAGGGTGCTGTTCACCAGCTC
TGCCAGAGCCTGGCTGGGAAGAACAGCGGCATGCCGCCCGGGGCAGCCGCCATCGCTGTG
CTCCCGGTTACCCTGGATACCCCGATGAACAGGAAATCAATGCCTGAGGCTGACTTCAGC
TCCTGGACACCCTTAGAATTCCTAGTTGAAACTTTCCATGACTGGATCACAGGGAAAAAC
CGACCGAGCTCAGGAAGCCTAATCCAGGTGGTAACCACAGAAGGAAGGACGGAACTCACC
CCAGCATATTTTTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X04882

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_2_Locus:
4p15.31

# Metabolic_Enzyme_2_SNPs:
rs3733570; rs12645938; rs3733569; rs2597775; rs1031327; rs1031326; rs1049581; rs1049600; rs699459; rs1049601; rs10604; rs699460; rs1049582; rs2597778; rs10008024; rs10006709; rs1411985; rs2315248; rs12644621; rs10939729; rs2518609; rs3822231; rs3733575; rs12512471; rs10004095; rs4698601; rs6819744; rs6827193; rs7660043; rs2518613; rs2518610; rs2597770; rs11722315; rs744729; rs2518616; rs731437; rs17458406; rs2253130; rs3796809; rs10013112; rs3094278; rs2252995; rs7696913; rs12647753; rs2518618; rs2597768; rs744731; rs2518615; rs7662925; rs9998021; rs10516314; rs10000532; rs10011038; rs2244804; rs12644449; rs12498807; rs9995626; rs3775922; rs10084995; rs11946133; rs3733572; rs2597777; rs12511229; rs13121927; rs3733573; rs28418409; rs10939724; rs10939725; rs7670743; rs3775921; rs3733574; rs3822234; rs2597767; rs744730; rs7676618; rs10030250; rs10020171; rs2518624; rs2518625; rs2597766; rs6449303; rs6811303; rs2244788; rs2597765; rs2305316; rs2597764; rs2597781; rs2518623; rs1031325; rs2315246; rs2315247; rs12512495; rs11556809; rs2518608; rs11556811; rs41268391; rs1803486; rs35601449; rs9995723; rs28407193; rs2305315; rs2518614; rs6841929; rs34374888; rs35810383; rs2597769; rs2518611; rs2597771; rs10027962; rs10031275; rs3733571; rs28678909; rs2597774; rs28587968; rs28465580; rs10008333; rs41268393; rs28547068; rs7436922; rs28394602; rs36202813; rs28548890; rs4083729; rs10028346; rs34235865; rs28391487; rs10050325; rs5856425; rs35863325; rs28375535; rs34319569; rs34528211; rs11736337; rs3822233; rs28435289; rs2597773; rs2518612; rs35068359; rs12498326; rs34914923; rs34012502; rs13137081; rs35469730; rs34100425; rs35826618; rs28449900; rs10632253; rs12647416; rs28580482; rs34858847; rs35314811; rs2597776; rs10598892; rs3217604; rs2597779; rs28621908; rs5856426; rs11351628; rs10022501; rs28425622; rs7685575; rs2518622; rs2597772; rs35054011; rs34311884; rs7660847; rs36094070; rs35198436; rs3066734; rs2597780; rs11935131; rs6823650; rs7672603; rs7694662; rs2518606; rs11556808; rs2597782; rs2518607; rs10026004; rs11733530; rs12499694; rs13128422; rs13128427; rs13128864; rs13131273; rs13138275; rs1473352; rs1551091; rs1551092; rs16895134; rs16895143; rs1868733; rs1868734; rs1868735; rs2122571; rs2247952; rs2518603; rs2518604; rs2518605; rs2518626; rs2597752; rs2597753; rs2597754; rs2597755; rs2597756; rs2597757; rs2597758; rs2597783; rs2597784; rs2597786; rs2697688; rs2697689; rs4698189; rs4698599; rs4698603; rs6817052; rs6835304; rs7661303

# Metabolic_Enzyme_2_General_References:
3031582; 3033643; 9744478; 8262916; 7627180; 8326489; 2116088; 10408783; 11153907

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5505

# Metabolic_Enzyme_3_Name:
Tyrosine 3-monooxygenase

# Metabolic_Enzyme_3_Synonyms:
Tyrosine 3-hydroxylase; TH

# Metabolic_Enzyme_3_Gene_Name:
TH

# Metabolic_Enzyme_3_Protein_Sequence:
>Tyrosine 3monooxygenase
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTP
RSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPR
ATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVR
QVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEI
AFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNI
PQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCC
HELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQNGEVKAYG
AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYAS
RIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG

# Metabolic_Enzyme_3_Number_of_Residues:
528

# Metabolic_Enzyme_3_Molecular_Weight:
58525

# Metabolic_Enzyme_3_Theoretical_pI:
6.25

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  tyrosine 3-monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  catecholamine metabolism
Process:  catecholamine biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Plays an important role in the physiology of adrenergic neurons

# Metabolic_Enzyme_3_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_3_Reaction:
L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00351:Biopterin_H

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.14.16.2

# Metabolic_Enzyme_3_GenBank_ID_Protein:
37127

# Metabolic_Enzyme_3_SwissProt_ID:
TY3H_HUMAN (P07101)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
TH

# Metabolic_Enzyme_3_Geneatlas_id:
TH

# Metabolic_Enzyme_3_hgnc_id:
HGNC:11782

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>1575 bp
ATGCCCACCCCCGACGCCACCACGCCACAGGCCAAGGGCTTCCGCAGGGCCGTGTCTGAG
CTGGACGCCAAGCAGGCAGAGGCCATCATGGGCGCCCCGGGGCCCAGCCTCACAGGCTCT
CCGTGGCCTGGAACTGCAGCCCCAGCTGCATCCTACACCCCCACCCCAAGGTCCCCGCGG
TTCATTGGGCGCAGGCAGAGCCTCATCGAGGACGCCCGCAAGGAGCGGGAGGCGGCGGTG
GCAGCAGCGGCCGCTGCAGTCCCCTCGGAGCCCGGGGACCCCCTGGAGGCTGTGGCCTTT
GAGGAGAAGGAGGGGAAGGCCGTGCTAAACCTGCTCTTCTCCCCGAGGGCCACCAAGCCC
TCGGCGCTGTCCCGAGCTGTGAAGGTGTTTGAGACGTTTGAAGCCAAAATCCACCATCTA
GAGACCCGGCCCGCCCAGAGGCCGCGAGCTGGGGGCCCCCACCTGGAGTACTTCGTGCGC
CTCGAGGTGCGCCGAGGGGACCTGGCCGCCCTGCTCAGTGGTGTGCGCCAGGTGTCAGAG
GACGTGCGCAGCCCCGCGGGGCCCAAGGTCCCCTGGTTCCCAAGAAAAGTGTCAGAGCTG
GACAAGTGTCATCACCTGGTCACCAAGTTCGACCCTGACCTGGACTTGGACCACCCGGGC
TTCTCGGACCAGGTGTACCGCCAGCGCAGGAAGCTGATTGCTGAGATCGCCTTCCAGTAC
AGGCACGGCGACCCGATTCCCCGTGTGGAGTACACCGCCGAGGAGATTGCCACCTGGAAG
GAGGTCTACACCACGCTGAAGGGCCTCTACGCCACGCACGCCTGCGGGGAGCACCTGGAG
GCCTTTGCTTTGCTGGAGCGCTTCAGCGGCTACCGGGAAGACAATATCCCCCAGCTGGAG
GACGTCTCCCGCTTCCTGAAGGAGCGCACGGGCTTCCAGCTGCGGCCTGTGGCCGGCCTG
CTGTCCGCCCGGGACTTCCTGGCCAGCCTGGCCTTCCGCGTGTTCCAGTGCACCCAGTAT
ATCCGCCACGCGTCCTCGCCCATGCACTCCCCTGAGCCGGACTGCTGCCACGAGCTGCTG
GGGCACGTGCCCATGCTGGCCGACCGCACCTTCGCGCAGTTCTCGCAGGACATTGGCCTG
GCGTCCCTGGGGGCCTCGGATGAGGAAATTGAGAAGCTGTCCACGCTGTCATGGTTCACG
GTGGAGTTCGGGCTGTGTAAGCAGAACGGGGAGGTGAAGGCCTATGGTGCCGGGCTGCTG
TCCTCCTACGGGGAGCTCCTGCACTGCCTGTCTGAGGAGCCTGAGATTCGGGCCTTCGAC
CCTGAGGCTGCGGCCGTGCAGCCCTACCAAGACCAGACGTACCAGTCAGTCTACTTCGTG
TCTGAGAGCTTCAGTGACGCCAAGGACAAGCTCAGGAGCTATGCCTCACGCATCCAGCGC
CCCTTCTCCGTGAAGTTCGACCCGTACACGCTGGCCATCGACGTGCTGGACAGCCCCCAG
GCCGTGCGGCGCTCCCTGGAGGGTGTCCAGGATGAGCTGGACACCCTTGCCCATGCGCTG
AGTGCCATTGGCTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
Y00414

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_3_Locus:
11p15.5

# Metabolic_Enzyme_3_SNPs:
rs6356; rs7950050; rs6357; rs34510659; rs11826260; rs3842725; rs10840489; rs11825601; rs4074905; rs12419447; rs2070762; rs7482510; rs3842722; rs7925924; rs7942881; rs11826130; rs7483805; rs7483056; rs4072826; rs4072824; rs7925375; rs7479936; rs4072823; rs3842723; rs10743149; rs10770140; rs3842727; rs7119275; rs7115640; rs10840490; rs10770141; rs11564711; rs10840491; rs3842726; rs11042962; rs10770142; rs28934581; rs28934579; rs28934580; rs1800033; rs36097848; rs3842724; rs1799833; rs11564716; rs34723540; rs6578990; rs11042950; rs3842721; rs35596265; rs11564713; rs11564712; rs36009557; rs4930043; rs36010304; rs7925784; rs35996457; rs4072825; rs35125951; rs11564714; rs35444567; rs34965351; rs11564715; rs11564717; rs10734659; rs11564718; rs1800032; rs10743152; rs10770143; rs10840447; rs10840452; rs10840495; rs10840496; rs10840502; rs11042965; rs11042966; rs11042971; rs11042976; rs11042978; rs11042982; rs11042984; rs11042987; rs11564709; rs11564710; rs11564720; rs2000993; rs28494588; rs28933985; rs3842733; rs3842738; rs3842741; rs3842748; rs3842752; rs3842753; rs3842754; rs3842756; rs3842768; rs3842769; rs3842770; rs3842775; rs4929964; rs4929966; rs4930046; rs5505; rs5506; rs5507; rs6578993; rs689; rs7110099; rs7128097; rs7482891; rs7936868

# Metabolic_Enzyme_3_General_References:
2882428; 2888085; 2887169; 2902075; 2892893; 2896667; 7814018; 7789962; 8528210; 8817341; 9613851; 9754624; 9703425; 10391209; 11246459

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5673

# Metabolic_Enzyme_4_Name:
Sepiapterin reductase

# Metabolic_Enzyme_4_Synonyms:
SPR

# Metabolic_Enzyme_4_Gene_Name:
SPR

# Metabolic_Enzyme_4_Protein_Sequence:
>Sepiapterin reductase
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSG
LRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV
NNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML
FQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQK
LLSLLEKDEFKSGAHVDFYDK

# Metabolic_Enzyme_4_Number_of_Residues:
261

# Metabolic_Enzyme_4_Molecular_Weight:
28049

# Metabolic_Enzyme_4_Theoretical_pI:
8.19

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  sepiapterin reductase activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  cellular metabolism
Process:  aromatic compound metabolism
Process:  aromatic compound biosynthesis
Process:  pteridine and derivative biosynthesis
Process:  tetrahydrobiopterin biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin

# Metabolic_Enzyme_4_Pathway:
map00790  Folate biosynthesis

# Metabolic_Enzyme_4_Reaction:
7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.1.1.153

# Metabolic_Enzyme_4_GenBank_ID_Protein:
338021

# Metabolic_Enzyme_4_SwissProt_ID:
SPRE_HUMAN (P35270)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
SPR

# Metabolic_Enzyme_4_Geneatlas_id:
SPR

# Metabolic_Enzyme_4_hgnc_id:
HGNC:11257

# Metabolic_Enzyme_4_PDB_ID:
1Z6Z

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_4_Gene_Sequence:
>786 bp
ATGGAGGGCGGGCTGGGGCGTGCTGTGTGCTTGCTGACCGGGGCCTCCCGCGGCTTCGGC
CGGACGCTGGCCCCGCTCCTGGCCTCGCTGCTGTCGCCCGGCTCCGTGCTTGTCCTTAGC
GCCCGCAACGACGAGGCACTGCGCCAGCTGGAGGCCGAGCTGGGCGCCGAGCGGTCTGGC
CTGCGCGTGGTGCGGGTGCCCGCCGACCTGGGCGCCGAGGCCGGCTTGCAGCAGCTGCTC
GGCGCCCTGCGCGAGCTCCCCCGGCCCAAGGGGCTGCAGCGACTGCTGCTTATCAACAAC
GCGGGCTCTCTTGGGGATGTGTCCAAAGGCTTCGTGGACCTGAGTGACTCCACTCAAGTG
AACAACTACTGGGCACTGAACTTGACCTCCATGCTCTGCCTGACTTCCAGCGTCCTGAAG
GCCTTCCCGGACAGTCCTGGCCTCAACAGAACCGTGGTTAACATCTCGTCCCTCTGTGCC
CTGCAACCTTTCAAAGGCTGGGCGCTGTACTGTGCAGGAAAGGCTGCTCGTGATATGCTG
TTCCAGGTCCTGGCGCTGGAGGAACCTAATGTGAGGGTGCTGAACTATGCCCCAGGTCCT
CTGGACACAGACATGCAGCAGTTGGCCCGGGAGACCTCCGTGGACCCAGACATGCGAAAA
GGGCTGCAGGAGCTGAAGGCAAAGGGGAAGCTGGTGGATTGCAAGGTGTCAGCCCAGAAA
CTGCTGAGCTTACTGGAAAAGGACGAGTTCAAGTCTGGAGCCCACGTGGACTTCTATGAC
AAATAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M76231

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_4_Locus:
2p14-p12

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
1883349; 8440319; 11825621

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5709

# Metabolic_Enzyme_5_Name:
Tryptophan 5-hydroxylase 1

# Metabolic_Enzyme_5_Synonyms:
Tryptophan 5-monooxygenase 1

# Metabolic_Enzyme_5_Gene_Name:
TPH1

# Metabolic_Enzyme_5_Protein_Sequence:
>Tryptophan 5hydroxylase 1
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI

# Metabolic_Enzyme_5_Number_of_Residues:
444

# Metabolic_Enzyme_5_Molecular_Weight:
50986

# Metabolic_Enzyme_5_Theoretical_pI:
7.23

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  tryptophan 5-monooxygenase activity
Function:  amine binding
Function:  amino acid binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  neurotransmitter metabolism
Process:  neurotransmitter biosynthesis
Process:  serotonin biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
L-tryptophan + tetrahydrobiopterin + O(2) = 5- hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_5_Pathway:
map00380  Tryptophan metabolism

# Metabolic_Enzyme_5_Reaction:
L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01842:ACT;
PF00351:Biopterin_H

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.14.16.4

# Metabolic_Enzyme_5_GenBank_ID_Protein:
37955

# Metabolic_Enzyme_5_SwissProt_ID:
TPH1_HUMAN (P17752)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
TPH1

# Metabolic_Enzyme_5_Geneatlas_id:
TPH1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:12008

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Not Available

# Metabolic_Enzyme_5_Gene_Sequence:
>1335 bp
ATGATTGAAGACAATAAGGAGAACAAAGACCATTCCTTAGAAAGGGGAAGAGCAAGTCTC
ATTTTTTCCTTAAAGAATGAAGTTGGAGGACTTATAAAAGCCCTGAAAATCTTTCAGGAG
AAGCATGTGAATCTGTTACATATCGAGTCCCGAAAATCAAAAAGAAGAAACTCAGAATTT
GAGATTTTTGTTGACTGTGACATCAACAGAGAACAATTGAATGATATTTTTCATCTGCTG
AAGTCTCATACCAATGTTCTCTCTGTGAATCTACCAGATAATTTTACTTTGAAGGAAGAT
GGTATGGAAACTGTTCCTTGGTTTCCAAAGAAGATTTCTGACCTGGACCATTGTGCCAAC
AGAGTTCTGATGTATGGATCTGAACTAGATGCAGACCATCCTGGCTTCAAAGACAATGTC
TACCGTAAACGTCGAAAGTATTTTGCGGACTTGGCTATGAACTATAAACATGGAGACCCC
ATTCCAAAGGTTGAATTCACTGAAGAGGAGATTAAGACCTGGGGAACCGTATTCCAAGAG
CTCAACAAACTCTACCCAACCCATGCTTGCAGAGAGTATCTCAAAAACTTACCTTTGCTT
TCTAAATATTGTGGATATCGGGAGGATAATATCCCACAATTGGAAGATGTCTCCAACTTT
TTAAAAGAGCGTACAGGTTTTTCCATCCGTCCTGTGGCTGGTTACTTATCACCAAGAGAT
TTCTTATCAGGTTTAGCCTTTCGAGTTTTTCACTGCACTCAATATGTGAGACACAGTTCA
GATCCCTTCTATACCCCAGAGCCAGATACCTGCCATGAACTCTTAGGTCATGTCCCGCTT
TTGGCTGAACCTAGTTTTGCCCAATTCTCCCAAGAAATTGGCTTGGCTTCTCTTGGCGCT
TCAGAGGAGGCTGTTCAAAAACTGGCAACGTGCTACTTTTTCACTGTGGAGTTTGGTCTA
TGTAAACAAGATGGACAGCTAAGAGTCTTTGGTGCTGGCTTACTTTCTTCTATCAGTGAA
CTCAAACATGCACTTTCTGGACATGCCAAAGTAAAGCCCTTTGATCCCAAGATTACCTGC
AAACAGGAATGTCTTATCACAACTTTTCAAGATGTCTACTTTGTATCTGAAAGTTTTGAA
GATGCAAAGGAGAAGATGAGAGAATTTACCAAAACAATTAAGCGTCCATTTGGAGTGAAG
TATAATCCATATACACGGAGTATTCAGATCCTGAAAGACACCAAGAGCATAACCAGTGCC
ATGAATGAGCTGCAGCATGATCTCGATGTTGTCAGTGATGCCCTTGCTAAGGTCAGCAGG
AAGCCGAGTATCTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X52836

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_5_Locus:
11p15.3-p14

# Metabolic_Enzyme_5_SNPs:
rs211107; rs172423; rs2056246; rs211105; rs1800532; rs1799913; rs684302; rs508924; rs1607395; rs685657; rs211102; rs10488683; rs10741734; rs211106; rs169806; rs591556; rs17794760; rs10832874; rs7933505; rs211104; rs11606304; rs11575890; rs2237907; rs11024447; rs685247; rs685249; rs11024449; rs10832876; rs17721739; rs500135; rs480425; rs211108; rs623580; rs10488682; rs2108977; rs8176799; rs12098985; rs7129561; rs41274348; rs41274350; rs503964; rs490895; rs7926900; rs34779435; rs35527095; rs34366393; rs35266509; rs10638620; rs593839; rs10658055; rs593414; rs11575863; rs211100; rs11413954; rs502962; rs211101; rs35668313; rs490966; rs34768875; rs592588; rs3216310; rs34651161; rs12279367; rs12279256; rs491779; rs592576; rs34286483; rs34892919; rs34584326; rs10655479; rs211103; rs12279322; rs592536; rs11024448; rs10832875; rs12287062; rs12279255; rs36020452; rs36063783; rs34067973; rs35878128; rs1134530; rs34396122; rs1133758; rs11024454; rs12365674; rs12575070; rs211109; rs3741201; rs3741202; rs4537731; rs521318; rs6486403; rs652458; rs7110238; rs7122118; rs7130929

# Metabolic_Enzyme_5_General_References:
2377472; 7986090; 9751214; 12379098

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5512

# Metabolic_Enzyme_6_Name:
Phenylalanine-4-hydroxylase

# Metabolic_Enzyme_6_Synonyms:
PAH; Phe-4- monooxygenase

# Metabolic_Enzyme_6_Gene_Name:
PAH

# Metabolic_Enzyme_6_Protein_Sequence:
>Phenylalanine4hydroxylase
MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDV
NLTHIESRPS
RLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVP
WFPRTIQELDRFANQILSYGA
ELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVE
YMEEEKKTWGTVFKTLKSLYKTHACYEYNHIF
PLLEKYCGFHEDNIPQLEDVSQFLQTC
TGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPE
PDICHELLGHVPLFSD
RSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSS
FGELQ
YCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYD
PYTQR
IEVLDNTQQLKILADSINSEIGILCSALQKIK

# Metabolic_Enzyme_6_Number_of_Residues:
452

# Metabolic_Enzyme_6_Molecular_Weight:
51863

# Metabolic_Enzyme_6_Theoretical_pI:
6.57

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  phenylalanine 4-monooxygenase activity
Function:  amine binding
Function:  amino acid binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  L-phenylalanine metabolism
Process:  L-phenylalanine catabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
L-phenylalanine + tetrahydrobiopterin + O(2) = L-tyrosine + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_6_Pathway:
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis

# Metabolic_Enzyme_6_Reaction:
L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF01842:ACT;
PF00351:Biopterin_H

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.14.16.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
189937

# Metabolic_Enzyme_6_SwissProt_ID:
PH4H_HUMAN (P00439)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
PAH

# Metabolic_Enzyme_6_Geneatlas_id:
PAH

# Metabolic_Enzyme_6_hgnc_id:
HGNC:8582

# Metabolic_Enzyme_6_PDB_ID:
2PHM

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>1359 bp

ATGTCCACTGCGGTCCTGGAAAACCCAGGCTTGGGCAGGAAACTCTCTGACTTTGGACA
GGAAACAAGCT
ATATTGAAGACAACTGCAATCAAAATGGTGCCATATCACTGATCTTCT
CACTCAAAGAAGAAGTTGGTGC
ATTGGCCAAAGTATTGCGCTTATTTGAGGAGAATGAT
GTAAACCTGACCCACATTGAATCTAGACCTTCT
CGTTTAAAGAAAGATGAGTATGAATT
TTTCACCCATTTGGATAAACGTAGCCTGCCTGCTCTGACAAACA
TCATCAAGATCTTGA
GGCATGACATTGGTGCCACTGTCCATGAGCTTTCACGAGATAAGAAGAAAGACAC
AGTG
CCCTGGTTCCCAAGAACCATTCAAGAGCTGGACAGATTTGCCAATCAGATTCTCAGCTAT
GGAGCG
GAACTGGATGCTGACCACCCTGGTTTTAAAGATCCTGTGTACCGTGCAAGACG
GAAGCAGTTTGCTGACA
TTGCCTACAACTACCGCCATGGGCAGCCCATCCCTCGAGTGG
AATACATGGAGGAAGAAAAGAAAACATG
GGGCACAGTGTTCAAGACTCTGAAGTCCTTG
TATAAAACCCATGCTTGCTATGAGTACAATCACATTTTT
CCACTTCTTGAAAAGTACTG
TGGCTTCCATGAAGATAACATTCCCCAGCTGGAAGACGTTTCTCAATTCC
TGCAGACTT
GCACTGGTTTCCGCCTCCGACCTGTGGCTGGCCTGCTTTCCTCTCGGGATTTCTTGGGTG
G
CCTGGCCTTCCGAGTCTTCCACTGCACACAGTACATCAGACATGGATCCAAGCCCATG
TATACCCCCGAA
CCTGACATCTGCCATGAGCTGTTGGGACATGTGCCCTTGTTTTCAGA
TCGCAGCTTTGCCCAGTTTTCCC
AGGAAATTGGCCTTGCCTCTCTGGGTGCACCTGATG
AATACATTGAAAAGCTCGCCACAATTTACTGGTT
TACTGTGGAGTTTGGGCTCTGCAAA
CAAGGAGACTCCATAAAGGCATATGGTGCTGGGCTCCTGTCATCC
TTTGGTGAATTACA
GTACTGCTTATCAGAGAAGCCAAAGCTTCTCCCCCTGGAGCTGGAGAAGACAGCCA
TCC
AAAATTACACTGTCACGGAGTTCCAGCCCCTGTATTACGTGGCAGAGAGTTTTAATGATG
CCAAGGA
GAAAGTAAGGAACTTTGCTGCCACAATACCTCGGCCCTTCTCAGTTCGCTAC
GACCCATACACCCAAAGG
ATTGAGGTCTTGGACAATACCCAGCAGCTTAAGATTTTGGC
TGATTCCATTAACAGTGAAATTGGAATCC
TTTGCAGTGCCCTCCAGAAAATAAAGTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
K03020

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_6_Locus:
12q22-q24.2

# Metabolic_Enzyme_6_SNPs:
rs5030849; rs1042503; rs1126758; rs1801152; rs772897; rs2280615; rs1801153; rs2280616; rs1616681; rs1722387; rs940527; rs772893; rs937475; rs1722383; rs1522295; rs2251897; rs1718305; rs1722392; rs1617090; rs2133298; rs2245360; rs12425434; rs2270729; rs11111419; rs10860933; rs1718312; rs10860929; rs2242381; rs1722381; rs1498688; rs1718303; rs1498694; rs2252031; rs2247836; rs2251905; rs10860936; rs2037639; rs2056602; rs4646986; rs12580432; rs1522296; rs10860928; rs1522307; rs10778202; rs2712618; rs10860935; rs10512929; rs10860931; rs4764918; rs1718301; rs772896; rs1353766; rs11836916; rs1718307; rs798709; rs11111412; rs1357765; rs10778201; rs12297049; rs4264203; rs10860930; rs1522304; rs3847931; rs869916; rs7295308; rs1718300; rs772895; rs1391685; rs1718304; rs1718306; rs4646987; rs10778204; rs1915932; rs940528; rs937476; rs1814728; rs1722399; rs7310181; rs1072528; rs1568795; rs2251799; rs870072; rs3805120; rs12306510; rs937474; rs3805122; rs1718297; rs10778209; rs7964033; rs2251894; rs1353767; rs7131709; rs17842947; rs1718302; rs11111413; rs6539058; rs7485666; rs3847930; rs12302563; rs1568792; rs1718310; rs10860934; rs7295112; rs7295979; rs10778205; rs11838076; rs772894; rs1718298; rs7485659; rs1722382; rs10778208; rs1722389; rs12309781; rs7138986; rs12578292; rs2454388; rs11830620; rs3817446; rs11831257; rs11111408; rs7488136; rs7485655; rs11838082; rs7488937; rs12301066; rs34181115; rs34191345; rs3828473; rs772899; rs12309687; rs1718292; rs7958897; rs7958750; rs35774237; rs772898; rs1851381; rs10778203; rs11111411; rs10778207; rs12579415; rs11830089; rs10778200; rs3913258; rs12099586; rs12831013; rs1106703; rs11111414; rs12581989; rs17033372; rs7487151; rs1522306; rs3828474; rs1722390; rs11830010; rs2953059; rs11111410; rs7485683; rs10778206; rs12312872; rs12298125; rs10450750; rs12299182; rs11830600; rs10745953; rs1718311; rs10860932; rs1722401; rs2252026; rs7306260; rs2133296; rs4646988; rs7305565; rs17842946; rs1522305; rs1718299; rs7485331; rs1498691; rs1522299; rs17546516; rs4764917; rs9804733; rs1522297; rs17041406; rs9804734; rs9804735; rs17033310; rs17852373; rs5030860; rs5030850; rs5030844; rs5030859; rs5030853; rs5030845; rs5030841; rs5030858; rs5030846; rs5030857; rs5030842; rs5030847; rs5030856; rs5030843; rs5030848; rs5030854; rs1801145; rs17852374; rs1801146; rs1801147; rs1042575; rs35465699; rs7954004; rs1042517; rs2264807; rs12099867; rs2647897; rs35620841; rs3062641; rs36183603; rs36087290; rs34044682; rs12319699; rs11486309; rs28672962; rs34903440; rs7980371; rs34297779; rs2454390; rs5030855; rs12314561; rs5800541; rs12310461; rs7969007; rs11835429; rs36013270; rs34089141; rs1814727; rs35544736; rs28380089; rs11111416; rs5800545; rs34757647; rs11384108; rs3062683; rs11111403; rs10615224; rs2133295; rs11830601; rs2647898; rs34956913; rs28626587; rs7965426; rs12307398; rs3840258; rs34694965; rs2691046; rs2270730; rs2712619; rs5800539; rs35080156; rs36197099; rs12829528; rs12815628; rs12424675; rs34356627; rs34923793; rs12099657; rs12314229; rs5800540; rs2373950; rs34877550; rs1799970; rs2264808; rs3792590; rs10525182; rs2949366; rs4764717; rs34906755; rs34950520; rs36191797; rs34480214; rs7970760; rs10573967; rs34400076; rs34425560; rs35822536; rs1623295; rs34451887; rs1403053; rs35008014; rs3062642; rs11833762; rs3062651; rs7302089; rs10573968; rs7970836; rs34857170; rs36195189; rs36201576; rs7295778; rs11111415; rs11111404; rs12826510; rs2264805; rs7970576; rs5800538; rs34358876; rs12099871; rs34437790; rs11829260; rs34584245; rs2133297; rs1976893; rs1722391; rs1498692; rs34539983; rs3062690; rs35776069; rs11338333; rs28854495; rs10542654; rs10679406; rs36134134; rs2264624; rs28630510; rs2691045; rs28620071; rs1081847; rs10526127; rs1568791; rs3847932; rs5800537; rs10531439; rs35530192; rs1976895; rs5800543; rs28655776; rs12809761; rs35490165; rs11111409; rs12424546; rs2247184; rs12320836; rs34506832; rs1722384; rs11833709; rs2373951; rs5030852; rs35081455; rs34824304; rs35681476; rs35507682; rs1619404; rs10654199; rs35194286; rs35197515; rs35855475; rs2264625; rs1463823; rs11111405; rs11111418; rs2264806; rs35019215; rs11837660; rs34418090; rs5800535; rs5800536; rs12099868; rs11608454; rs11305173; rs34213541; rs34619720; rs12578276; rs35350743; rs2264623; rs34426190; rs35530065; rs35780730; rs12099870; rs35122890; rs7308175; rs1568793; rs2647899; rs12826142; rs28673013; rs35520828; rs28435260; rs28396626; rs28496869; rs2173444; rs1718309; rs12829846; rs2102005; rs5030861; rs34438405; rs34426240; rs34299540; rs3062645; rs4764919; rs12313998; rs7964941; rs34330841; rs35790027; rs5800542; rs12427231; rs12307663; rs7135561; rs28380242; rs1622379; rs10573966; rs35823784; rs12313245; rs1522298; rs12312033; rs36053636; rs34637625; rs34730283; rs34674687; rs9738302; rs35118563; rs35048664; rs7485315; rs17041408; rs1498690; rs35026116; rs1498689; rs5030654; rs10860925; rs11111402; rs17842962; rs34068029; rs4764916; rs7314670; rs7978669

# Metabolic_Enzyme_6_General_References:
2986678; 2461704; 9406548; 9843368; 9642259; 10694386; 11718561; 1679029; 2246858; 1301187; 8594560; 2840952; 2564729; 2615649; 1975559; 1671810; 2014802; 1672294; 1672290; 1679030; 1709636; 1358789; 1355066; 1363837; 1363838; 8406445; 8098245; 8068076; 8088845; 7833954; 8889583; 8889590; 9048935; 9101291; 9450897; 9521426; 9600453; 9452061; 9452062; 9792407; 9792411; 9852673; 10679941; 11326337; 11180595; 11385716; 11461196

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
6878

# Metabolic_Enzyme_7_Name:
Catalase

# Metabolic_Enzyme_7_Synonyms:
Not Available

# Metabolic_Enzyme_7_Gene_Name:
CAT

# Metabolic_Enzyme_7_Protein_Sequence:
>Catalase
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT
KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD
THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE
HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK
NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL

# Metabolic_Enzyme_7_Number_of_Residues:
527

# Metabolic_Enzyme_7_Molecular_Weight:
59757

# Metabolic_Enzyme_7_Theoretical_pI:
7.41

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  catalase activity
 ||
>>>
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide

# Metabolic_Enzyme_7_Pathway:
map00380  Tryptophan metabolism;
 map00680  Methane metabolism

# Metabolic_Enzyme_7_Reaction:
2 H2O2 = O2 + 2 H2O

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00199:Catalase

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.11.1.6

# Metabolic_Enzyme_7_GenBank_ID_Protein:
1228085

# Metabolic_Enzyme_7_SwissProt_ID:
CATA_HUMAN (P04040)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
CAT

# Metabolic_Enzyme_7_Geneatlas_id:
CAT

# Metabolic_Enzyme_7_hgnc_id:
HGNC:1516

# Metabolic_Enzyme_7_PDB_ID:
1F4J

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_7_Gene_Sequence:
>66 bp
ATGGCTGACAGCCGGGATCCCGCCAGCGACCAGATGCAGCACTGGAAGGAGCAGCGGGCC
GCGCAG

# Metabolic_Enzyme_7_GenBank_ID_Gene:
X04085

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_7_Locus:
11p13

# Metabolic_Enzyme_7_SNPs:
rs17880442; rs11032709; rs769217; rs35677492; rs1049982; rs2234940; rs1050032; rs566979; rs769218; rs511895; rs524167; rs494024; rs1408035; rs560807; rs10488736; rs2284367; rs482322; rs7947841; rs480496; rs11032699; rs2300182; rs2284365; rs7103083; rs499406; rs3758730; rs4755372; rs508370; rs7933285; rs1000343; rs554576; rs2073059; rs11032701; rs17886008; rs4755373; rs484214; rs6484722; rs543701; rs17884666; rs2420389; rs551929; rs480575; rs10836244; rs2179625; rs7113917; rs2268063; rs533425; rs12272630; rs17881488; rs486256; rs17884576; rs2073058; rs11604331; rs17884491; rs7120960; rs1408034; rs524154; rs7109778; rs7101395; rs17881288; rs12269988; rs7126610; rs10836235; rs16925608; rs16925614; rs11824384; rs2284368; rs17883121; rs2420388; rs4756146; rs16925606; rs17884086; rs2284364; rs7930427; rs12803540; rs1408036; rs17268652; rs2284366; rs17881567; rs2300181; rs7928213; rs11032702; rs16925581; rs525938; rs11032700; rs17881921; rs17884095; rs17885743; rs17881476; rs17883793; rs11826620; rs12270780; rs35915891; rs2268064; rs17883592; rs17884725; rs17881482; rs17880673; rs2284369; rs17883544; rs11032703; rs12273124; rs17884248; rs35755143; rs7126640; rs2076556; rs4755374; rs1055981; rs17884335; rs17884518; rs17880274; rs17883699; rs4756148; rs17886200; rs475043; rs564250; rs769214; rs9282626; rs7943316; rs9282627; rs7104301; rs17883920; rs1001179; rs17881029; rs17886350; rs2266625; rs34455645; rs3180560; rs11546300; rs1050028; rs2266629; rs2266619; rs14527; rs2266628; rs35012776; rs34964953; rs34727149; rs3831770; rs17886810; rs35927227; rs7121850; rs17885881; rs17882812; rs17885837; rs17880607; rs17882039; rs17881916; rs17880549; rs34138762; rs28586982; rs34503767; rs36074933; rs515130; rs35099202; rs35849009; rs17881846; rs17887048; rs17881224; rs17884421; rs34840731; rs17881231; rs35340649; rs35292563; rs17884242; rs12286702; rs35034960; rs28733253; rs17887248; rs35791482; rs35703808; rs35648206; rs34808995; rs35386961; rs34420404; rs856714; rs17883483; rs17884804; rs17883367; rs17883534; rs17880160; rs17886672; rs34281397; rs34790990; rs2982523; rs35122257; rs2284370; rs12798927; rs35781217; rs11032707; rs17886592; rs4483566; rs34890123; rs4272763; rs12789374; rs17881734; rs35330036; rs17883434; rs35081167; rs17886155; rs17886248; rs34840787; rs34890990; rs17881192; rs17881586; rs34267165; rs12786539; rs35834969; rs3818354; rs17884443; rs36224415; rs36224416; rs36224102; rs10312; rs10836230; rs10836233; rs10836234; rs11032717; rs1107573; rs11606946; rs12284341; rs12807961; rs12808450; rs1323690; rs1535718; rs1535719; rs1535720; rs1535721; rs16925525; rs2073057; rs208678; rs208679; rs208681; rs208682; rs208683; rs2231828; rs2266624; rs2266630; rs2296144; rs409598; rs554518; rs7109862; rs7114869; rs7118388; rs7928156; rs7941147; rs7944397; rs7949972

# Metabolic_Enzyme_7_General_References:
3755525; 3755526; 11728823; 8282800; 12665801; 6548744; 10666617; 10656833; 11134921

# Metabolic_Enzyme_7_References:
2900841

# Metabolic_Enzyme_8_ID:
7375

# Metabolic_Enzyme_8_Name:
Superoxide dismutase [Mn], mitochondrial precursor

# Metabolic_Enzyme_8_Synonyms:
Not Available

# Metabolic_Enzyme_8_Gene_Name:
SOD2

# Metabolic_Enzyme_8_Protein_Sequence:
>Superoxide dismutase Mn, mitochondrial precursor
MLSRAVCGTSRQLAPALGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVN
NLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEA
IKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLL
GIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK

# Metabolic_Enzyme_8_Number_of_Residues:
222

# Metabolic_Enzyme_8_Molecular_Weight:
24722

# Metabolic_Enzyme_8_Theoretical_pI:
8.45

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  metal ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on superoxide radicals as acceptor
Function:  superoxide dismutase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  superoxide metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems

# Metabolic_Enzyme_8_Pathway:
Not Available

# Metabolic_Enzyme_8_Reaction:
2 O2*- + 2 H+ = O2 + H2O2

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF02777:Sod_Fe_C;
PF00081:Sod_Fe_N

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.15.1.1

# Metabolic_Enzyme_8_GenBank_ID_Protein:
34709

# Metabolic_Enzyme_8_SwissProt_ID:
SODM_HUMAN (P04179)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
SOD2

# Metabolic_Enzyme_8_Geneatlas_id:
SOD2

# Metabolic_Enzyme_8_hgnc_id:
HGNC:11180

# Metabolic_Enzyme_8_PDB_ID:
1LUV

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_8_Gene_Sequence:
>669 bp
ATGTTGAGCCGGGCAGTGTGCGGCACCAGCAGGCAGCTGGCTCCGGCTTTGGGGTATCTG
GGCTCCAGGCAGAAGCACAGCCTCCCCGACCTGCCCTACGACTACGGCGCCCTGGAACCT
CACATCAACGCGCAGATCATGCAGCTGCACCACAGCAAGCACCACGCGGCCTACGTGAAC
AACCTGAACGTCAACGAGGAGAAGTACCAGGAGGCGTTGGCCAAGGGAGATGTTACAGCC
CAGATAGCTCTTCAGCCTGCACTGAAGTTCAATGGTGGTGGTCATATCAATCATAGCATT
TTCTGGACAAACCTCAGCCCTAACGGTGGTGGAGAACCCAAAGGGGAGTTGCTGGAAGCC
ATCAAACGTGACTTTGGTTCCTTTGACAAGTTTAAGGAGAAGCTGACGGCTGCATCTGTT
GGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAACGGGGACACTTACAA
ATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTG
GGGATTGATGTGTGGGAGCACGCTTACTACCTTCAGTATAAAAATGTCAGGCCTGATTAT
CTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAAGATACATGGCTTGC
AAAAAGTAA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X59445

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_8_Locus:
6q25.3

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
2462451; 3684581; 3399391; 2831093; 1988135; 1699607; 7702755; 14574404; 6386798; 7895732; 7498159; 9150946; 1394426; 8605177; 9537988; 9537987; 10852710; 11580280

# Metabolic_Enzyme_8_References:
16631534; 16891102

# Metabolic_Enzyme_9_ID:
8206

# Metabolic_Enzyme_9_Name:
Nitric-oxide synthase, endothelial

# Metabolic_Enzyme_9_Synonyms:
EC-NOS; NOS type III; NOSIII; Endothelial NOS; eNOS; Constitutive NOS; cNOS

# Metabolic_Enzyme_9_Gene_Name:
NOS3

# Metabolic_Enzyme_9_Protein_Sequence:
>Nitricoxide synthase, endothelial
MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAPEHSPPSSPLT
QPPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAP
EQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRN
APRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGD
FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPP
ELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMST
EIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDH
HAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW
KGSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGR
LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSS
PRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHF
CAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAA
RDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATIRSVENLQSSKSTRATIL
VRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGP
PPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRRY
EEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVL
AYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAP
FRGFWQERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSRE
PDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDMELD
EAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPGSDT
NSP

# Metabolic_Enzyme_9_Number_of_Residues:
1203

# Metabolic_Enzyme_9_Molecular_Weight:
133290

# Metabolic_Enzyme_9_Theoretical_pI:
7.27

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  monooxygenase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen
Function:  nitric-oxide synthase activity
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  biosynthesis
Process:  nitric oxide biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets

# Metabolic_Enzyme_9_Pathway:
map00330  Arginine and proline metabolism

# Metabolic_Enzyme_9_Reaction:
L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00667:FAD_binding_1;
PF00258:Flavodoxin_1;
PF00175:NAD_binding_1;
PF02898:NO_synthase

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 1.14.13.39

# Metabolic_Enzyme_9_GenBank_ID_Protein:
189212

# Metabolic_Enzyme_9_SwissProt_ID:
NOS3_HUMAN (P29474)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
NOS3

# Metabolic_Enzyme_9_Geneatlas_id:
NOS3

# Metabolic_Enzyme_9_hgnc_id:
HGNC:7876

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cell membrane; caveola. Cytoplasm; cytoskeleton. Golgi apparatus. Note= Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity

# Metabolic_Enzyme_9_Gene_Sequence:
>3612 bp
ATGGGCAACTTGAAGAGCGTGGCCCAGGAGCCTGGGCCACCCTGCGGCCTGGGGCTGGGG
CTGGGCCTTGGGCTGTGCGGCAAGCAGGGCCCAGCCACCCCGGCCCCTGAGCCCAGCCGG
GCCCCAGCATCCCTACTCCCACCAGCGCCAGAACACAGCCCCCCGAGCTCCCCGCTAACC
CAGCCCCCAGAGGGGCCCAAGTTCCCTCGTGTGAAGAACTGGGAGGTGGGGAGCATCACC
TATGACACCCTCAGCGCCCAGGCGCAGCAGGATGGGCCCTGCACCCCAAGACGCTGCCTG
GGCTCCCTGGTATTTCCACGGAAACTACAGGGCCGGCCCTCCCCCGGCCCCCCGGCCCCT
GAGCAGCTGCTGAGTCAGGCCCGGGACTTCATCAACCAGTACTACAGCTCCATTAAGAGG
AGCGGCTCCCAGGCCCACGAACAGCGGCTTCAAGAGGTGGAAGCCGAGGTGGCAGCCACA
GGCACCTACCAGCTTAGGGAGAGCGAGCTGGTGTTCGGGGCTAAGCAGGCCTGGCGCAAC
GCTCCCCGCTGCGTGGGCCGGATCCAGTGGGGGAAGCTGCAGGTGTTCGATGCCCGGGAC
TGCAGGTCTGCACAGGAAATGTTCACCTACATCTGCAACCACATCAAGTATGCCACCAAC
CGGGGCAACCTTCGCTCGGCCATCACAGTGTTCCCGCAGCGCTGCCCTGGCCGAGGAGAC
TTCCGAATCTGGAACAGCCAGCTGGTGCGCTACGCGGGCTACCGGCAGCAGGACGGCTCT
GTGCGGGGGGACCCAGCCAACGTGGAGATCACCGAGCTCTGCATTCAGCACGGCTGGACC
CCAGGAAACGGTCGCTTCGACGTGCTGCCCCTGCTGCTGCAGGCCCCAGATGAGCCCCCA
GAACTCTTCCTTCTGCCCCCCGAGCTGGTCCTTGAGGTGCCCCTGGAGCACCCCACGCTG
GAGTGGTTTGCAGCCCTGGGCCTGCGCTGGTACGCCCTCCCGGCAGTGTCCAACATGCTG
CTGGAAATTGGGGGCCTGGAGTTCCCCGCAGCCCCCTTCAGTGGCTGGTACATGAGCACT
GAGATCGGCACGAGGAACCTGTGTGACCCTCACCGCTACAACATCCTGGAGGATGTGGCT
GTCTGCATGGACCTGGATACCCGGACCACCTCGTCCCTGTGGAAAGACAAGGCAGCAGTG
GAAATCAACGTGGCCGTGCTGCACAGTTACCAGCTAGCCAAAGTCACCATCGTGGACCAC
CACGCCGCCACGGCCTCTTTCATGAAGCACCTGGAGAATGAGCAGAAGGCCAGGGGGGGC
TGCCCTGCAGACTGGGCCTGGATCGTGCCCCCCATCTCGGGCAGCCTCACTCCTGTTTTC
CATCAGGAGATGGTCAACTATTTCCTGTCCCCGGCCTTCCGCTACCAGCCAGACCCCTGG
AAGGGGAGTGCCGCCAAGGGCACCGGCATCACCAGGAAGAAGACCTTTAAAGAAGTGGCC
AACGCCGTGAAGATCTCCGCCTCGCTCATGGGCACGGTGATGGCGAAGCGAGTGAAGGCG
ACAATCCTGTATGGCTCCGAGACCGGCCGGGCCCAGAGCTACGCACAGCAGCTGGGGAGA
CTCTTCCGGAAGGCTTTTGATCCCCGGGTCCTGTGTATGGATGAGTATGACGTGGTGTCC
CTCGAACACGAGACGCTGGTGCTGGTGGTAACCAGCACATTTGGGAATGGGGATCCCCCG
GAGAATGGAGAGAGCTTTGCAGCTGCCCTGATGGAGATGTCCGGCCCCTACAACAGCTCC
CCTCGGCCGGAACAGCACAAGAGTTATAAGATCCGCTTCAACAGCATCTCCTGCTCAGAC
CCACTGGTGTCCTCTTGGCGGCGGAAGAGGAAGGAGTCCAGTAACACAGACAGTGCAGGG
GCCCTGGGCACCCTCAGGTTCTGTGTGTTCGGGCTCGGCTCCCGGGCATACCCCCACTTC
TGCGCCTTTGCTCGTGCCGTGGACACACGGCTGGAGGAACTGGGCGGGGAGCGGCTGCTG
CAGCTGGGCCAGGGCGACGAGCTGTGCGGCCAGGAGGAGGCCTTCCGAGGCTGGGCCCAG
GCTGCCTTCCAGGCCGCCTGTGAGACCTTCTGTGTGGGAGAGGATGCCAAGGCCGCCGCC
CGAGACATCTTCAGCCCCAAACGGAGCTGGAAGCGCCAGAGGTACCGGCTGAGCGCCCAG
GCCGAGGGCCTGCAGTTGCTGCCAGGTCTGATCCACGTGCACAGGCGGAAGATGTTCCAG
GCTACAATCCGCTCAGTGGAAAACCTGCAAAGCAGCAAGTCCACGAGGGCCACCATCCTG
GTGCGCCTGGACACCGGAGGCCAGGAGGGGCTGCAGTACCAGCCGGGGGACCACATAGGT
GTCTGCCCGCCCAACCGGCCCGGCCTTGTGGAGGCGCTGCTGAGCCGCGTGGAGGACCCG
CCGGCGCCCACTGAGCCCGTGGCAGTAGAGCAGCTGGAGAAGGGCAGCCCTGGTGGCCCT
CCCCCCGGCTGGGTGCGGGACCCCCGGCTGCCCCCGTGCACGCTGCGCCAGGCTCTCACC
TTCTTCCTGGACATCACCTCCCCACCCAGCCCTCAGCTCTTGCGGCTGCTCAGCACCTTG
GCAGAAGAGCCCAGGGAACAGCAGGAGCTGGAGGCCCTCAGCCAGGATCCCCGACGCTAC
GAGGAGTGGAAGTGGTTCCGCTGCCCCACGCTGCTGGAGGTGCTGGAGCAGTTCCCGTCG
GTGGCGCTGCCTGCCCCACTGCTCCTCACCCAGCTGCCTCTGCTCCAGCCCCGGTACTAC
TCAGTCAGCTCGGCACCCAGCACCCACCCAGGAGAGATCCACCTCACTGTAGCTGTGCTG
GCATACAGGACTCAGGATGGGCTGGGCCCCCTGCACTATGGAGTCTGCTCCACGTGGCTA
AGCCAGCTCAAGCCCGGAGACCCTGTGCCCTGCTTCATCCGGGGGGCTCCCTCCTTCCGG
CTGCCACCCGATCCCAGCTTGCCCTGCATCCTGGTGGGTCCAGGCACTGGCATTGCCCCC
TTCCGGGGATTCTGGCAGGAGCGGCTGCATGACATTGAGAGCAAAGGGCTGCAGCCCACT
CCCATGACTTTGGTGTTCGGCTGCCGATGCTCCCAACTTGACCATCTCTACCGCGACGAG
GTGCAGAACGCCCAGCAGCGCGGGGTGTTTGGCCGAGTCCTCACCGCCTTCTCCCGGGAA
CCTGACAACCCCAAGACCTACGTGCAGGACATCCTGAGGACGGAGCTGGCTGCGGAGGTG
CACCGCGTGCTGTGCCTCGAGCGGGGCCACATGTTTGTCTGCGGCGATGTTACCATGGCA
ACCAACGTCCTGCAGACCGTGCAGCGCATCCTGGCGACGGAGGGCGACATGGAGCTGGAC
GAGGCCGGCGACGTCATCGGCGTGCTGCGGGATCAGCAACGCTACCACGAAGACATTTTC
GGGCTCACGCTGCGCACCCAGGAGGTGACAAGCCGCATACGCACCCAGAGCTTTTCCTTG
CAGGAGCGTCAGTTGCGGGGCGCAGTGCCCTGGGCGTTCGACCCTCCCGGCTCAGACACC
AACAGCCCCTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
M93718

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_9_Locus:
7q36

# Metabolic_Enzyme_9_SNPs:
rs3918234; rs3918232; rs1799983; rs3918201; rs3918166; rs2566514; rs9282804; rs34967063; rs3918233; rs35281220; rs1549758; rs9282803; rs3918163; rs1800779; rs3918226; rs3918159; rs3918160; rs2243311; rs3918162; rs2070744; rs3918225; rs1800783; rs3918155; rs3918158; rs3918157; rs3918156; rs3918161; rs1808593; rs743507; rs1008140; rs3793341; rs3918196; rs3730002; rs3730003; rs3918188; rs2566511; rs891511; rs3918177; rs3730305; rs3730009; rs867225; rs3918182; rs1007311; rs3834873; rs2853792; rs3918192; rs3918227; rs3918175; rs3918171; rs1800782; rs3918187; rs2853795; rs3918205; rs3918176; rs3918202; rs1541861; rs3918178; rs753482; rs3918204; rs3793342; rs3918174; rs3918167; rs3730010; rs1800781; rs3918203; rs1800780; rs3918198; rs3918180; rs3918194; rs3918184; rs891512; rs3729625; rs743506; rs3918181; rs3918190; rs3918228; rs3918172; rs3918230; rs3918169; rs3918191; rs3730001; rs2853796; rs3918186; rs3918170; rs3918165; rs3918183; rs34919745; rs3730006; rs34372288; rs35795287; rs3918193; rs34554797; rs3918179; rs3918164; rs13305982; rs3918197; rs3918229; rs2243310; rs3918231; rs3918189; rs3918173; rs3918168; rs3918195; rs3918199; rs3918185; rs3918200; rs11771443; rs41377046; rs6947833; rs7792133; rs41508746; rs11552661; rs2566519; rs34417010; rs2566516; rs35886277; rs11371169; rs35480369; rs33915751; rs3730306; rs2566513; rs11974098; rs2566508; rs13305984; rs2566512; rs13311166; rs13310774; rs3730007; rs7776461; rs2853798; rs13305985; rs2853791; rs34110189; rs35771718; rs41385244; rs2853800; rs2566515; rs34833695; rs41490944; rs1799984; rs13310854; rs10539416; rs2566509; rs2566506; rs28763995; rs6969597; rs41322052; rs2853797; rs2853794; rs2566510; rs10539415; rs10255980; rs28763996; rs41408449; rs13310763; rs2566507; rs41394247; rs10595051; rs4725985; rs34617549; rs3828997; rs2853793; rs34204527; rs10531586; rs10265237; rs10276930; rs10277237; rs1064353; rs1077872; rs12666088; rs12703107; rs13307588; rs2373929; rs2373961; rs2373962; rs2566518; rs3134740; rs3730011; rs3730012; rs3800787; rs3918207; rs3918211; rs3918212; rs3918215; rs3918218; rs3918220; rs4496877; rs6951150; rs933163

# Metabolic_Enzyme_9_General_References:
1378832; 1379542; 7688726; 7509596; 7519987; 7514568; 7475956; 10074942; 12437348; 9737779

# Metabolic_Enzyme_9_References:
10580434; 10749876; 10924132; 11356602

# Metabolic_Enzyme_10_ID:
8027

# Metabolic_Enzyme_10_Name:
Nitric-oxide synthase, brain

# Metabolic_Enzyme_10_Synonyms:
NOS type I; Neuronal NOS; N-NOS; nNOS; Constitutive NOS; NC-NOS; bNOS

# Metabolic_Enzyme_10_Gene_Name:
NOS1

# Metabolic_Enzyme_10_Protein_Sequence:
>Nitricoxide synthase, brain
MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA
GDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI
RVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAP
RPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQV
DRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPS
KCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLF
PLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRC
VGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVW
NSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQ
IPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGV
RDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSAT
ESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHV
WKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCE
IFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQ
EERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAF
GHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANN
SLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFV
RLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGV
ISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEY
EEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIV
SYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAP
FRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSRE
PDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAE
DAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS

# Metabolic_Enzyme_10_Number_of_Residues:
1434

# Metabolic_Enzyme_10_Molecular_Weight:
160972

# Metabolic_Enzyme_10_Theoretical_pI:
7.44

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  cofactor binding
Function:  coenzyme binding
Function:  NADP binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  FAD binding
Function:  tetrapyrrole binding
Function:  heme binding
Function:  protein binding
Function:  calmodulin binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  monooxygenase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen
Function:  nitric-oxide synthase activity
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
Function:  transporter activity
Function:  electron transporter activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  biosynthesis
Process:  nitric oxide biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter

# Metabolic_Enzyme_10_Pathway:
map00330  Arginine and proline metabolism

# Metabolic_Enzyme_10_Reaction:
L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00667:FAD_binding_1;
PF00258:Flavodoxin_1;
PF00175:NAD_binding_1;
PF02898:NO_synthase;
PF00595:PDZ

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 1.14.13.39

# Metabolic_Enzyme_10_GenBank_ID_Protein:
642526

# Metabolic_Enzyme_10_SwissProt_ID:
NOS1_HUMAN (P29475)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
NOS1

# Metabolic_Enzyme_10_Geneatlas_id:
NOS1

# Metabolic_Enzyme_10_hgnc_id:
HGNC:7872

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cell membrane; sarcolemma; peripheral membrane protein. Cell projection; dendritic spine. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity)

# Metabolic_Enzyme_10_Gene_Sequence:
>4305 bp
ATGGAGGATCACATGTTCGGTGTTCAGCAAATCCAGCCCAATGTCATTTCTGTTCGTCTC
TTCAAGCGCAAAGTTGGGGGCCTGGGATTTCTGGTGAAGGAGCGGGTCAGTAAGCCGCCC
GTGATCATCTCTGACCTGATTCGTGGGGGCGCCGCAGAGCAGAGTGGCCTCATCCAGGCC
GGAGACATCATTCTTGCGGTCAACGGCCGGCCCTTGGTGGACCTGAGCTATGACAGCGCC
CTGGAGGTACTCAGAGGCATTGCCTCTGAGACCCACGTGGTCCTCATTCTGAGGGGCCCT
GAAGGTTTCACCACGCACCTGGAGACCACCTTTACAGGTGATGGGACCCCCAAGACCATC
CGGGTGACACAGCCCCTGGGTCCCCCCACCAAAGCCGTGGATCTGTCCCACCAGCCACCG
GCCGGCAAAGAACAGCCCCTGGCAGTGGATGGGGCCTCGGGTCCCGGGAATGGGCCTCAG
CATGCCTACGATGATGGGCAGGAGGCTGGCTCACTCCCCCATGCCAACGGCCTGGCCCCC
AGGCCCCCAGGCCAGGACCCCGCGAAGAAAGCAACCAGAGTCAGCCTCCAAGGCAGAGGG
GAGAACAATGAACTGCTCAAGGAGATAGAGCCTGTGCTGAGCCTTCTCACCAGTGGGAGC
AGAGGGGTCAAGGGAGGGGCACCTGCCAAGGCAGAGATGAAAGATATGGGAATCCAGGTG
GACAGAGATTTGGACGGCAAGTCACACAAACCTCTGCCCCTCGGCGTGGAGAACGACCGA
GTCTTCAATGACCTATGGGGGAAGGGCAATGTGCCTGTCGTCCTCAACAACCCATATTCA
GAGAAGGAGCAGCCCCCCACCTCAGGAAAACAGTCCCCCACAAAGAATGGCAGCCCCTCC
AAGTGTCCACGCTTCCTCAAGGTCAAGAACTGGGAGACTGAGGTGGTTCTCACTGACACC
CTCCACCTTAAGAGCACATTGGAAACGGGATGCACTGAGTACATCTGCATGGGCTCCATC
ATGCATCCTTCTCAGCATGCAAGGAGGCCTGAAGACGTCCGCACAAAAGGACAGCTCTTC
CCTCTCGCCAAAGAGTTTATTGATCAATACTATTCATCAATTAAAAGATTTGGCTCCAAA
GCCCACATGGAAAGGCTGGAAGAGGTGAACAAAGAGATCGACACCACTAGCACTTACCAG
CTCAAGGACACAGAGCTCATCTATGGGGCCAAGCACGCCTGGCGGAATGCCTCGCGCTGT
GTGGGCAGGATCCAGTGGTCCAAGCTGCAGGTATTCGATGCCCGTGACTGCACCACGGCC
CACGGGATGTTCAACTACATCTGTAACCATGTCAAGTATGCCACCAACAAAGGGAACCTC
AGGTCTGCCATCACCATATTCCCCCAGAGGACAGACGGCAAGCACGACTTCCGAGTCTGG
AACTCCCAGCTCATCCGCTACGCTGGCTACAAGCAGCCTGACGGCTCCACCCTGGGGGAC
CCAGCCAATGTGCAGTTCACAGAGATATGCATACAGCAGGGCTGGAAACCGCCTAGAGGC
CGCTTCGATGTCCTGCCGCTCCTGCTTCAGGCCAACGGCAATGACCCTGAGCTCTTCCAG
ATTCCTCCAGAGCTGGTGTTGGAAGTTCCCATCAGGCACCCCAAGTTTGAGTGGTTCAAG
GACCTGGGGCTGAAGTGGTACGGCCTCCCCGCCGTGTCCAACATGCTCCTAGAGATTGGC
GGCCTGGAGTTCAGCGCCTGTCCCTTCAGTGGCTGGTACATGGGCACAGAGATTGGTGTC
CGCGACTACTGTGACAACTCCCGCTACAATATCCTGGAGGAAGTGGCCAAGAAGATGAAC
TTAGACATGAGGAAGACGTCCTCCCTGTGGAAGGACCAGGCGCTGGTGGAGATCAATATC
GCGGTTCTCTATAGCTTCCAGAGTGACAAAGTGACCATTGTTGACCATCACTCCGCCACC
GAGTCCTTCATTAAGCACATGGAGAATGAGTACCGCTGCCGGGGGGGCTGCCCTGCCGAC
TGGGTGTGGATCGTGCCCCCCATGTCCGGAAGCATCACCCCTGTGTTCCACCAGGAGATG
CTCAACTACCGGCTCACCCCCTCCTTCGAATACCAGCCTGATCCCTGGAACACGCATGTC
TGGAAAGGCACCAACGGGACCCCCACAAAGCGGCGAGCCATCGGCTTCAAGAAGCTAGCA
GAAGCTGTCAAGTTCTCGGCCAAGCTGATGGGGCAGGCTATGGCCAAGAGGGTGAAAGCG
ACCATCCTCTATGCCACAGAGACAGGCAAATCGCAAGCTTATGCCAAGACCTTGTGTGAG
ATCTTCAAACACGCCTTTGATGCCAAGGTGATGTCCATGGAAGAATATGACATTGTGCAC
CTGGAACATGAAACTCTGGTCCTTGTGGTCACCAGCACCTTTGGCAATGGAGATCCCCCT
GAGAATGGGGAGAAATTCGGCTGTGCTTTGATGGAAATGAGGCACCCCAACTCTGTGCAG
GAAGAAAGGAAGAGCTACAAGGTCCGATTCAACAGCGTCTCCTCCTACTCTGACTCCCAA
AAATCATCAGGCGATGGGCCCGACCTCAGAGACAACTTTGAGAGTGCTGGACCCCTGGCC
AATGTGAGGTTCTCAGTTTTTGGCCTCGGCTCACGAGCATACCCTCACTTTTGCGCCTTC
GGACACGCTGTGGACACCCTCCTGGAAGAACTGGGAGGGGAGAGGATCCTGAAGATGAGG
GAAGGGGATGAGCTCTGTGGGCAGGAAGAGGCTTTCAGGACCTGGGCCAAGAAGGTCTTC
AAGGCAGCCTGTGATGTCTTCTGTGTGGGAGATGATGTCAACATTGAAAAGGCCAACAAT
TCCCTCATCAGCAATGATCGCAGCTGGAAGAGAAACAAGTTCCGCCTCACCTTTGTGGCC
GAAGCTCCAGAACTCACACAAGGTCTATCCAATGTCCACAAAAAGCGAGTCTCAGCTGCC
CGGCTCCTTAGCCGTCAAAACCTCCAGAGCCCTAAATCCAGTCGGTCAACTATCTTCGTG
CGTCTCCACACCAACGGGAGCCAGGAGCTGCAGTACCAGCCTGGGGACCACCTGGGTGTC
TTCCCTGGCAACCACGAGGACCTCGTGAATGCCCTGATCGAGCGGCTGGAGGACGCGCCG
CCTGTCAACCAGATGGTGAAAGTGGAACTGCTGGAGGAGCGGAACACGGCTTTAGGTGTC
ATCAGTAACTGGACAGACGAGCTCCGCCTCCCGCCCTGCACCATCTTCCAGGCCTTCAAG
TACTACCTGGACATCACCACGCCACCAACGCCTCTGCAGCTGCAGCAGTTTGCCTCCCTA
GCTACCAGCGAGAAGGAGAAGCAGCGTCTGCTGGTCCTCAGCAAGGGTTTGCAGGAGTAC
GAGGAATGGAAATGGGGCAAGAACCCCACCATCGTGGAGGTGCTGGAGGAGTTCCCATCT
ATCCAGATGCCGGCCACCCTGCTCCTGACCCAGCTGTCCCTGCTGCAGCCCCGCTACTAT
TCCATCAGCTCCTCCCCAGACATGTACCCTGATGAAGTGCACCTCACTGTGGCCATCGTT
TCCTACCGCACTCGAGATGGAGAAGGACCAATTCACCACGGCGTATGCTCCTCCTGGCTC
AACCGGATACAGGCTGACGAACTGGTCCCCTGTTTCGTGAGAGGAGCACCCAGCTTCCAC
CTGCCCCGGAACCCCCAAGTCCCCTGCATCCTCGTTGGACCAGGCACCGGCATTGCCCCT
TTCCGAAGCTTCTGGCAACAGCGGCAATTTGATATCCAACACAAAGGAATGAACCCCTGC
CCCATGGTCCTGGTCTTCGGGTGCCGGCAATCCAAGATAGATCATATCTACAGGGAAGAG
ACCCTGCAGGCCAAGAACAAGGGGGTCTTCAGAGAGCTGTACACGGCTTACTCCCGGGAG
CCAGACAAACCAAAGAAGTACGTGCAGGACATCCTGCAGGAGCAGCTGGCGGAGTCTGTG
TACCGAGCCCTGAAGGAGCAAGGGGGCCACATATACGTCTGTGGGGACGTCACCATGGCT
GCTGATGTCCTCAAAGCCATCCAGCGCATCATGACCCAGCAGGGGAAGCTCTCGGCAGAG
GACGCCGGCGTATTCATCAGCCGGATGAGGGATGACAACCGATACCATGAGGATATTTTT
GGAGTCACCCTGCGAACGTACGAAGTGACCAACCGCCTTAGATCTGAGTCCATTGCCTTC
ATTGAAGAGAGCAAAAAAGACACCGATGAGGTTTTCAGCTCCTAA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
U17327

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_10_Locus:
12q24.2-q24.31

# Metabolic_Enzyme_10_SNPs:
rs9658403; rs9658445; rs3741475; rs2293054; rs34375182; rs1047735; rs9658446; rs9658276; rs9658501; rs2293044; rs13377860; rs9658362; rs9658278; rs816296; rs1681506; rs1552227; rs570234; rs576881; rs7298863; rs1123425; rs11068415; rs579604; rs1552228; rs3782218; rs693534; rs7958407; rs3782221; rs10507279; rs499776; rs4767533; rs527590; rs1001087; rs4766845; rs482555; rs17509231; rs10160911; rs545343; rs939473; rs1004356; rs545654; rs7132722; rs10161234; rs2682826; rs11068454; rs571895; rs9658261; rs9658265; rs9658566; rs4767534; rs9658562; rs483589; rs3782219; rs17617937; rs9658559; rs9658266; rs12424669; rs7135565; rs9658565; rs9658567; rs551340; rs3782222; rs9658561; rs9658256; rs9658557; rs1966119; rs3741473; rs3741481; rs11609784; rs9658564; rs7134020; rs12425916; rs4767532; rs9658273; rs9658260; rs16947485; rs9658267; rs16947469; rs9658264; rs7305221; rs9658263; rs7301872; rs9658563; rs4482113; rs1004355; rs34406980; rs9658258; rs9658259; rs9658274; rs16947472; rs11833539; rs2101238; rs9658268; rs12826020; rs17430966; rs471075; rs9658262; rs10850814; rs11068452; rs17431015; rs9658269; rs3782220; rs2650163; rs816353; rs549098; rs2077171; rs816361; rs816357; rs532967; rs2293050; rs1520810; rs2293046; rs884847; rs2293051; rs2291908; rs845820; rs1483757; rs816363; rs2682820; rs1093330; rs12578547; rs7970178; rs7309163; rs6490123; rs816360; rs7133438; rs10850810; rs2293047; rs2293045; rs561712; rs1093325; rs7299154; rs7310618; rs7138586; rs10774909; rs539291; rs10850809; rs522910; rs2650162; rs4767524; rs2006789; rs816352; rs1879418; rs2293048; rs9658498; rs2682825; rs7314935; rs2682822; rs4767525; rs4766836; rs9658474; rs547954; rs2293052; rs2650164; rs3825102; rs904658; rs4767529; rs7961096; rs10850803; rs2682821; rs1353939; rs567581; rs7961147; rs7964845; rs530393; rs7977109; rs939474; rs7298903; rs7295972; rs9658361; rs9658420; rs3782195; rs816354; rs526810; rs549040; rs3782214; rs7967328; rs567910; rs7961049; rs9658335; rs3782202; rs11068447; rs2293053; rs3837438; rs7967614; rs9658443; rs9658447; rs9658321; rs9658463; rs9658315; rs1875140; rs4766842; rs9658309; rs864641; rs9658301; rs816358; rs11068451; rs2682819; rs1879419; rs10744891; rs9658384; rs9658535; rs9658490; rs1520812; rs4767527; rs3741477; rs7312437; rs7308402; rs552268; rs11068422; rs9658426; rs9658551; rs9658304; rs2271984; rs471871; rs9658281; rs9658286; rs11068445; rs9658372; rs12579387; rs12321917; rs9658504; rs816347; rs9658317; rs9658471; rs12099598; rs3782203; rs11611788; rs11068450; rs11836446; rs7304788; rs12829185; rs2893707; rs3782211; rs4766843; rs9658481; rs473640; rs7306863; rs10850805; rs12811583; rs9658300; rs9658450; rs3741476; rs9658491; rs11068438; rs1093327; rs11835005; rs9658397; rs2291909; rs528558; rs816346; rs9658377; rs9658330; rs816348; rs9658534; rs9658427; rs816362; rs3782200; rs9658303; rs9658525; rs9658480; rs9658351; rs11612772; rs474523; rs9658282; rs11068446; rs499262; rs2271986; rs9658536; rs9658340; rs9658382; rs9658354; rs16947411; rs10774910; rs9658449; rs9658505; rs2293055; rs17584270; rs9658479; rs1520811; rs7959232; rs3782212; rs9658552; rs1093328; rs7139134; rs6490121; rs1607817; rs816351; rs3782204; rs2271987; rs9658466; rs3782213; rs816293; rs1093329; rs733334; rs3741480; rs509190; rs6490124; rs7297780; rs2139733; rs3782201; rs9658424; rs9658414; rs4767526; rs816359; rs16947443; rs9658478; rs4766841; rs9658353; rs9658314; rs10850808; rs7960451; rs12830203; rs877995; rs9658544; rs3825103; rs865857; rs9658556; rs551846; rs3215291; rs9658327; rs9658452; rs9658507; rs17617737; rs9658527; rs9658312; rs9658418; rs493948; rs11835908; rs9658339; rs7977360; rs9658391; rs9658432; rs9658532; rs9658408; rs9658293; rs12824048; rs9658518; rs9658409; rs12814350; rs7959158; rs12319599; rs9658367; rs10850806; rs1843019; rs9658325; rs499813; rs4766837; rs9658472; rs9658550; rs9658543; rs11068426; rs3782198; rs1843020; rs492596; rs9658497; rs4767523; rs9658280; rs9658496; rs12319601; rs9658360; rs9658503; rs9658417; rs9658380; rs9658508; rs9658370; rs2393208; rs7979667; rs6490122; rs11068429; rs552275; rs9658526; rs3782206; rs7315796; rs9658464; rs9658313; rs11068437; rs816349; rs41462551; rs497373; rs9658352; rs553715; rs524946; rs9658433; rs9658322; rs9658546; rs10774908; rs9658411; rs9658512; rs7305526; rs9658341; rs904657; rs9658329; rs9658337; rs9658422; rs4766838; rs11282297; rs9658308; rs9658517; rs9658381; rs4767528; rs7306231; rs9658371; rs3782207; rs9658469; rs9658385; rs9658485; rs12424169; rs9658398; rs9658406; rs9658475; rs10850812; rs9658438; rs9658369; rs524945; rs9658465; rs10850804; rs744664; rs884846; rs11068431; rs9658459; rs9658378; rs9658494; rs7968487; rs9658283; rs496505; rs11832564; rs11831562; rs9658522; rs9658399; rs7486002; rs12810591; rs12811676; rs9658515; rs9658419; rs12227767; rs9658323; rs9658529; rs9658387; rs816356; rs11068418; rs9658423; rs9658336; rs505381; rs9658549; rs9658307; rs10850802; rs9658454; rs9658326; rs2271985; rs11068428; rs41386547; rs9658555; rs9658350; rs9658444; rs7139256; rs9658333; rs9658401; rs9658324; rs9658390; rs9658506; rs9658492; rs9658483; rs9658448; rs11068443; rs816297; rs9658388; rs9658318; rs3782196; rs9658458; rs3782208; rs9658453; rs1818732; rs16947421; rs9658524; rs816355; rs16947426; rs12227412; rs9658364; rs508304; rs9658495; rs12423054; rs9658521; rs9658434; rs2056352; rs9658373; rs9658320; rs7303718; rs12815584; rs7978471; rs3782205; rs9658537; rs7957789; rs11068444; rs9658487; rs6490120; rs9658429; rs9658542; rs11068416; rs12422515; rs3741479; rs9658374; rs9658297; rs11068427; rs16947447; rs9658473; rs9658306; rs9658528; rs478027; rs12578810; rs9658548; rs9658305; rs9658462; rs9669709; rs11616132; rs9658247; rs9658255; rs9658570; rs9658573; rs9658251; rs9658254; rs9658253; rs11615277; rs9658252; rs9658574; rs9658250; rs7303761; rs9658482; rs41514244; rs41356652; rs41474747; rs9658279; rs4519169; rs9658356; rs41340250; rs9658275; rs9658533; rs41410247; rs9658500; rs2291906; rs9658545; rs9658277; rs41347148; rs41413747; rs9658302; rs41459647; rs7314856; rs12816421; rs36054002; rs11068456; rs9658272; rs3825106; rs35032440; rs12319061; rs35983257; rs11350853; rs35097914; rs41472247; rs3782217; rs34353855; rs5801225; rs9658271; rs4463915; rs34401373; rs3825107; rs9658569; rs34639968; rs11613900; rs12811414; rs11068455; rs3837440; rs5022854; rs41444054; rs35276550; rs9658558; rs1966118; rs900625; rs12828499; rs35484983; rs7976697; rs12315429; rs35546970; rs34677429; rs10532086; rs3841422; rs12812145; rs3937939; rs35667543; rs34618211; rs34266766; rs35856269; rs12813001; rs36021382; rs41511544; rs9658568; rs12827766; rs12322249; rs1384871; rs3814246; rs11068453; rs36211363; rs550720; rs35253422; rs9658560; rs9658257; rs11610556; rs41502449; rs34054618; rs16947488; rs9658270; rs34539949; rs5801226; rs2133681; rs7304189; rs34482297; rs1384870; rs12307475; rs34494717; rs9658431; rs12829099; rs35718760; rs10532868; rs41376150; rs9658389; rs35666260; rs41372344; rs35405377; rs9658359; rs11068440; rs41485049; rs41472952; rs9658319; rs11068436; rs34872534; rs9658477; rs488484; rs12312476; rs28662816; rs11068419; rs9658541; rs36065807; rs7980322; rs11068425; rs9658538; rs1879415; rs9658531; rs34374129; rs9658467; rs2393207; rs12829054; rs41379845; rs10687797; rs2170784; rs41486744; rs35453078; rs9658316; rs11314930; rs2291907; rs41507951; rs41420145; rs9658328; rs9658553; rs9658425; rs34889380; rs9658456; rs34243436; rs35266333; rs41325947; rs35665808; rs41500645; rs33913257; rs9658413; rs3071370; rs1093326; rs9658410; rs33975959; rs34929026; rs7133096; rs12314660; rs12826953; rs10554360; rs11611292; rs514015; rs41432944; rs35267348; rs11347925; rs34837209; rs9658486; rs9658342; rs12821989; rs12304129; rs9658436; rs11435908; rs17430697; rs9658396; rs35296681; rs17508609; rs9658375; rs9658332; rs36001580; rs1915362; rs9658520; rs9658435; rs34869803; rs12366342; rs12307719; rs9658421; rs41390845; rs9658394; rs36083220; rs9658338; rs35293946; rs9658386; rs12826015; rs41383549; rs35267485; rs10655356; rs34973520; rs41458949; rs9658358; rs41396553; rs17430945; rs9658455; rs35031132; rs3070338; rs9658476; rs9658416; rs9658437; rs7307623; rs41366351; rs13328977; rs9658493; rs9658442; rs1681505; rs555648; rs35223509; rs9658468; rs12827134; rs9658366; rs7308875; rs10565062; rs9658451; rs41503148; rs11423140; rs41383344; rs12307476; rs9658345; rs41420451; rs9658407; rs9658334; rs7297846; rs35879104; rs41455345; rs9658376; rs9658539; rs5801224; rs9658513; rs34947893; rs11068424; rs9658523; rs3837439; rs28607014; rs7971809; rs41476045; rs41455546; rs34631148; rs35303550; rs41399550; rs9658346; rs12300042; rs11068448; rs41457644; rs34022865; rs34229487; rs10611949; rs11068433; rs35736046; rs41497546; rs41486647; rs12812274; rs41361947; rs10672770; rs34828673; rs9658392; rs41395745; rs16947370; rs12829334; rs34305939; rs527540; rs12823828; rs9658509; rs9658540; rs9658355; rs35277030; rs9658292; rs41478451; rs36064109; rs34104292; rs12831124; rs9658344; rs35666257; rs9658295; rs41325949; rs12318813; rs35555584; rs41426547; rs11834656; rs41366451; rs41515346; rs10595279; rs4569079; rs9658395; rs9658402; rs41451245; rs35994161; rs41501744; rs41445448; rs41437349; rs2139734; rs9658511; rs11326692; rs2626134; rs10686986; rs10567372; rs3782197; rs35578100; rs41455545; rs3830565; rs34287548; rs7961022; rs11068423; rs41418246; rs9658415; rs9658412; rs9658470; rs9658357; rs10626233; rs9658287; rs10588671; rs11068439; rs9658489; rs12314144; rs35236225; rs9658291; rs9658488; rs34165543; rs41452648; rs9658290; rs9658393; rs9658441; rs34589596; rs34443779; rs11429761; rs12425008; rs4766840; rs34321698; rs9658310; rs12811988; rs9658484; rs2293049; rs41373045; rs9658461; rs9658428; rs12314981; rs34457241; rs9658349; rs41475345; rs41359947; rs12581092; rs34249731; rs9658516; rs12322448; rs9658298; rs35725343; rs11068442; rs11068449; rs1607818; rs9658368; rs528507; rs9658519; rs35301315; rs35146766; rs11068435; rs35656036; rs36232027; rs9658284; rs9658400; rs3837437; rs35556284; rs12821259; rs9658547; rs9658343; rs11413465; rs9658405; rs12425263; rs12229416; rs4500558; rs9658499; rs34918872; rs36020061; rs34665031; rs28722559; rs11373221; rs9658365; rs35536440; rs41362246; rs9658379; rs41418550; rs12811221; rs11398507; rs9658430; rs34474757; rs10536808; rs9658510; rs9658439; rs4641555; rs11068430; rs35152095; rs34896001; rs41350246; rs28491965; rs11411313; rs10602103; rs9658440; rs11391019; rs12826961; rs9658404; rs9658502; rs41448349; rs36033657; rs11608271; rs41531646; rs9658383; rs35976283; rs1879416; rs2170783; rs9658285; rs9658530; rs9658294; rs12829328; rs35704581; rs33951458; rs816350; rs7137324; rs41494753; rs34385734; rs9658288; rs41417246; rs9658348; rs35750643; rs34322576; rs12815242; rs9658514; rs34438096; rs35320403; rs41384051; rs9658311; rs41337253; rs12308759; rs9658457; rs34594895; rs41344546; rs35285730; rs41403945; rs34411345; rs9658576; rs9658571; rs34041352; rs35842215; rs9658248; rs34133408; rs35873722; rs9658246; rs10693750; rs9658572; rs36077311; rs9658249; rs12818970; rs34230698; rs9658575; rs10774906; rs10774907; rs1105026; rs11068411; rs11068457; rs11068458; rs11068459; rs12302304; rs12423857; rs1273887; rs1879417; rs1915361; rs35611019; rs36016891; rs4767520; rs4767535; rs527017; rs957948

# Metabolic_Enzyme_10_General_References:
7528745; 7515942; 7678401; 8879752; 9111048

# Metabolic_Enzyme_10_References:
12709574; 15161750; 15891335; 16216381

# Metabolic_Enzyme_11_ID:
8379

# Metabolic_Enzyme_11_Name:
Pterin-4-alpha-carbinolamine dehydratase

# Metabolic_Enzyme_11_Synonyms:
PHS; 4-alpha- hydroxy-tetrahydropterin dehydratase; Phenylalanine hydroxylase- stimulating protein; Pterin carbinolamine dehydratase; PCD; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; Dimerization cofactor of HNF1; DCoH

# Metabolic_Enzyme_11_Gene_Name:
PCBD1

# Metabolic_Enzyme_11_Protein_Sequence:
>Pterin4alphacarbinolamine dehydratase
MAGKAHRLSAEERDQLLPNLRAVGWNELEGRDAIFKQFHFKDFNRAFGFMTRVALQAEKL
DHHPEWFNVY
NKVHITLSTHECAGLSERDINLASFIEQVAVSMT

# Metabolic_Enzyme_11_Number_of_Residues:
104

# Metabolic_Enzyme_11_Molecular_Weight:
12000

# Metabolic_Enzyme_11_Theoretical_pI:
6.80

# Metabolic_Enzyme_11_GO_Classification:
Not Available

# Metabolic_Enzyme_11_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
Regulates the dimerization of homeodomain protein HNF-1- alpha and enhances its transcriptional activity

# Metabolic_Enzyme_11_Pathway:
Not Available

# Metabolic_Enzyme_11_Reaction:
(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF01329:Pterin_4a

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 4.2.1.96

# Metabolic_Enzyme_11_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_11_SwissProt_ID:
PHS_HUMAN (P61457)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
PCBD1

# Metabolic_Enzyme_11_Geneatlas_id:
PCBD1

# Metabolic_Enzyme_11_hgnc_id:
HGNC:8646

# Metabolic_Enzyme_11_PDB_ID:
1DCP

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Cytoplasm. Nucleus. Note=Cytoplasmic and/or nuclear

# Metabolic_Enzyme_11_Gene_Sequence:
Not Available

# Metabolic_Enzyme_11_GenBank_ID_Gene:
M83742

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_11_Locus:
10q22

# Metabolic_Enzyme_11_SNPs:
rs9712; rs827237; rs827241; rs827242; rs12570183; rs12218438; rs7900028; rs2854611; rs1767233; rs844124; rs16928052; rs2854610; rs11554325; rs15279; rs2630336; rs827238; rs827239; rs7916976; rs2854615; rs2788579; rs12249858; rs10999573; rs12769766; rs2854613; rs2854614; rs1683940; rs827240; rs10999574; rs2854616; rs10999572; rs12783479; rs34835357; rs2630331; rs5786013; rs34500372; rs10999571; rs35541340; rs1683922; rs1683926; rs1059266; rs10762410; rs10823633; rs12248382; rs12252993; rs12253257; rs12259664; rs12264592; rs12267758; rs12770815; rs1338643; rs17533359; rs17533443; rs2688758; rs2691148; rs2881; rs4747110; rs6480465; rs6480466; rs7096028; rs7917488; rs7917828; rs827243; rs827244; rs827246; rs827349; rs827350; rs827351; rs877034; rs923177; rs973982

# Metabolic_Enzyme_11_General_References:
1763325; 7763270; 10098606; 8444860; 8352282; 9760199

# Metabolic_Enzyme_11_References:
10403117; 14729142; 14766237; 8178819

# Macromolecular_Interacting_Partner_1_ID:
6070

# Macromolecular_Interacting_Partner_1_Name:
Dihydrofolate reductase

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
DHFR

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Dihydrofolate reductase
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
187

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
21453

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.60

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NADP binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
Function:  dihydrofolate reductase activity
 ||
>>>
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
Process:  glycine biosynthesis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Coenzyme transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8- dihydrofolate + NADPH

# Macromolecular_Interacting_Partner_1_Pathway:
map00670  One carbon pool by folate;
 map00790  Folate biosynthesis

# Macromolecular_Interacting_Partner_1_Reaction:
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00186:DHFR_1

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 1.5.1.3

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
182724

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
DYR_HUMAN (P00374)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
DHFR

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
DHFR

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:2861

# Macromolecular_Interacting_Partner_1_PDB_ID:
1MVT

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>564 bp
ATGGTTGGTTCGCTAAACTGCATCGTCGCTGTGTCCCAGAACATGGGCATCGGCAAGAAC
GGGGACCTGCCCTGGCCACCGCTCAGGAATGAATTCAGATATTTCCAGAGAATGACCACA
ACCTCTTCAGTAGAAGGTAAACAGAATCTGGTGATTATGGGTAAGAAGACCTGGTTCTCC
ATTCCTGAGAAGAATCGACCTTTAAAGGGTAGAATTAATTTAGTTCTCAGCAGAGAACTC
AAGGAACCTCCACAAGGAGCTCATTTTCTTTCCAGAAGTCTAGATGATGCCTTAAAACTT
ACTGAACAACCAGAATTAGCAAATAAAGTAGACATGGTCTGGATAGTTGGTGGCAGTTCT
GTTTATAAGGAAGCCATGAATCACCCAGGCCATCTTAAACTATTTGTGACAAGGATCATG
CAAGACTTTGAAAGTGACACGTTTTTTCCAGAAATTGATTTGGAGAAATATAAACTTCTG
CCAGAATACCCAGGTGTTCTCTCTGATGTCCAGGAGGAGAAAGGCATTAAGTACAAATTT
GAAGTATATGAGAAGAATGATTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
J00140

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_1_Locus:
5q11.2-q13.2

# Macromolecular_Interacting_Partner_1_SNPs:
rs1643630; rs2618372; rs1643650; rs6875184; rs10072026; rs11951910; rs836818; rs1643638; rs1677693; rs1643658; rs10078190; rs836823; rs836821; rs1643659; rs1677691; rs1643635; rs1677694; rs1677634; rs13161245; rs865646; rs1677633; rs844370; rs10052238; rs966762; rs865647; rs1650709; rs2431221; rs10054574; rs34965641; rs865645; rs1643649; rs525054; rs245104; rs11951283; rs1650700; rs1650711; rs245099; rs1650710; rs6453522; rs1677700; rs372069; rs34563643; rs1677696; rs1650714; rs1643664; rs864133; rs1623489; rs1650701; rs35709834; rs1677661; rs11742668; rs836819; rs861373; rs1677692; rs836822; rs860717; rs34781740; rs1677701; rs1650706; rs1650713; rs2560424; rs863216; rs2897261; rs1643657; rs1643661; rs1643634; rs1677666; rs12517451; rs1650723; rs12109877; rs1650720; rs14435; rs11112; rs1053136; rs11550953; rs1129240; rs1129243; rs2431220; rs7387; rs190293; rs34764978; rs35262215; rs1129242; rs34087552; rs10685456; rs1650717; rs13182730; rs1677706; rs10474631; rs34268388; rs35740086; rs6863377; rs10076523; rs2545005; rs1677704; rs1643662; rs1643647; rs1677697; rs7706270; rs10557831; rs2560423; rs3958540; rs863217; rs1677699; rs1643637; rs165957; rs3991269; rs4406117; rs34545755; rs3991268; rs245101; rs11305000; rs1643656; rs1677636; rs1677684; rs11490741; rs1650712; rs34132382; rs1677705; rs2897260; rs1677688; rs3958541; rs34289983; rs863215; rs1677686; rs1650707; rs34468903; rs1650715; rs245103; rs34184316; rs1677702; rs34288321; rs35372305; rs34122957; rs1643660; rs7705115; rs34674884; rs2434329; rs10942929; rs2927911; rs1650716; rs7706404; rs3797876; rs2405873; rs1222967; rs245105; rs1677689; rs34359040; rs11749051; rs1643648; rs2560422; rs1650718; rs1677631; rs10942928; rs34504711; rs11952744; rs3958542; rs35633165; rs1643636; rs836820; rs1650708; rs245100; rs7725721; rs34141487; rs11491447; rs1643663; rs34540063; rs8180493; rs1677687; rs1677695; rs33948142; rs1677685; rs13165178; rs10077031; rs34143020; rs390975; rs12109309; rs10168; rs10474632; rs1105524; rs1222809; rs1232027; rs1382539; rs1382540; rs1382541; rs1382542; rs1478834; rs1478835; rs1643639; rs1643641; rs1643646; rs1643655; rs1650675; rs1650676; rs1650681; rs1650692; rs1650694; rs1650695; rs1650696; rs1650697; rs1677626; rs1677667; rs1677670; rs1677682; rs1677703; rs245102; rs380691; rs3822706; rs384925; rs408626; rs442767; rs453544; rs6878815; rs6897872; rs701383; rs861365

# Macromolecular_Interacting_Partner_1_General_References:
6323448; 6687716; 6235374; 3383852; 2248959; 9374868; 1731871

# Macromolecular_Interacting_Partner_1_References:
4004257; 7756597

# Macromolecular_Interacting_Partner_2_ID:
7197

# Macromolecular_Interacting_Partner_2_Name:
Corticotropin-lipotropin precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Pro-opiomelanocortin; POMC[Contains: NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin]

# Macromolecular_Interacting_Partner_2_Gene_Name:
POMC

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Corticotropinlipotropin precursor
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
267

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
29424

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Beta-endorphin and Met-enkephalin are endogenous opiates

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00976:ACTH_domain;
PF08384:NPP;
PF08035:Op_neuropeptide

# Macromolecular_Interacting_Partner_2_Signals:
1-26

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
190188

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
COLI_HUMAN (P01189)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
POMC

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
POMC

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:9201

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>789 bp
TGCAGCCGCTCGGGGGCCCTGTTGCTGGCCTTGCTGCTTCAGGCCTCCATGGAAGTGCGT
GGCTGGTGCCTGGAGAGCAGCCAGTGTCAGGACCTCACCACGGAAAGCAACCTGCTGGAG
TGCATCCGGGCCTGCAAGCCCGACCTCTCGGCCGAGACTCCCATGTTCCCGGGAAATGGC
GACGAGCAGCCTCTGACCGAGAACCCCCGGAAGTACGTCATGGGCCACTTCCGCTGGGAC
CGATTCGGCCGCCGCAACAGCAGCAGCAGCGGCAGCAGCGGCGCAGGGCAGAAGCGCGAG
GACGTCTCAGCGGGCGAAGACTGCGGCCCGCTGCCTGAGGGCGGCCCCGAGCCCCGCAGC
GATGGTGCCAAGCCGGGCCCGCGCGAGGGCAAGCGCTCCTACTCCATGGAGCACTTCCGC
TGGGGCAAGCCGGTGGGCAAGAAGCGGCGCCCAGTGAAGGTGTACCCTAACGGCGCCGAG
GACGAGTCGGCCGAGGCCTTCCCCCTGGAGTTCAAGAGGGAGCTGACTGGCCAGCGACTC
CGGGAGGGAGATGGCCCCGACGGCCCTGCCGATGACGGCGCAGGGGCCCAGGCCGACCTG
GAGCACAGCCTGCTGGTGGCGGCCGAGAAGAAGGACGAGGGCCCCTACAGGATGGAGCAC
TTCCGCTGGGGCAGCCCGCCCAAGGACAAGCGCTACGGCGGTTTCATGACCTCCGAGAAG
AGCCAGACGCCCCTGGTGACGCTGTTCAAAAACGCCATCATCAAGAACGCCTACAAGAAG
GGCGAGTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M38297

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_2_Locus:
2p23.3

# Macromolecular_Interacting_Partner_2_SNPs:
rs28932472; rs8192606; rs28932471; rs35254395; rs8192605; rs28930368; rs2071345; rs34650613; rs1042571; rs11679531; rs6713532; rs7565877; rs6713396; rs12473543; rs6756695; rs6545975; rs6756566; rs28932474; rs28932476; rs28932475; rs28932473; rs10654394; rs28932470; rs3039380; rs35411223; rs35023083; rs33950052; rs7591899; rs15461; rs2071344; rs13388660; rs9973478; rs11353932; rs13404336; rs7565427; rs34619618; rs8192607; rs35639116; rs34526166; rs10188864; rs10195561; rs11892647; rs12472851; rs13418937; rs17046887; rs17046891; rs1866146; rs2071343; rs2118404; rs2164808; rs3769671; rs3795955; rs3820935; rs6545976; rs6719226; rs6734859; rs7589318; rs7605927; rs934778

# Macromolecular_Interacting_Partner_2_General_References:
6274691; 6299668; 6314261; 3606677; 6254047; 6945581; 6267033; 6272808; 4352834; 4334191; 4338630; 4347148; 1264228; 195688; 2424570; 2839146; 7828531; 9768693; 10193875; 11244459

# Macromolecular_Interacting_Partner_2_References:
16293777; 3009141

# Macromolecular_Interacting_Partner_3_ID:
7549

# Macromolecular_Interacting_Partner_3_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
INS

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_3_Signals:
1-24

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
INS

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11p15.5

# Macromolecular_Interacting_Partner_3_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_3_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_3_References:
11009561; 11167133; 11230293; 16160605

# Macromolecular_Interacting_Partner_4_ID:
7551

# Macromolecular_Interacting_Partner_4_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_4_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_4_Locus:
6p21.3

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_4_References:
10788433; 8245346; 8883940

# Macromolecular_Interacting_Partner_5_ID:
7552

# Macromolecular_Interacting_Partner_5_Name:
Interferon gamma precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
IFN-gamma; Immune interferon

# Macromolecular_Interacting_Partner_5_Gene_Name:
IFNG

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Interferon gamma precursor
MKYTSYILAFQLCIVLGSLGCYCQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWK
EESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTN
YSVTDLNVQRKAIHELIQVMAELSPAAKTGKRKRSQMLFRGRRASQ

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
166

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
19349

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
10.01

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interferon-gamma receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00714:IFN-gamma

# Macromolecular_Interacting_Partner_5_Signals:
1-23

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
32692

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
IFNG_HUMAN (P01579)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
IFNG

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
IFNG

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:5438

# Macromolecular_Interacting_Partner_5_PDB_ID:
1HIG

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>501 bp
ATGAAATATACAAGTTATATCTTGGCTTTTCAGCTCTGCATCGTTTTGGGTTCTCTTGGC
TGTTACTGCCAGGACCCATATGTAAAAGAAGCAGAAAACCTTAAGAAATATTTTAATGCA
GGTCATTCAGATGTAGCGGATAATGGAACTCTTTTCTTAGGCATTTTGAAGAATTGGAAA
GAGGAGAGTGACAGAAAAATAATGCAGAGCCAAATTGTCTCCTTTTACTTCAAACTTTTT
AAAAACTTTAAAGATGACCAGAGCATCCAAAAGAGTGTGGAGACCATCAAGGAAGACATG
AATGTCAAGTTTTTCAATAGCAACAAAAAGAAACGAGATGACTTCGAAAAGCTGACTAAT
TATTCGGTAACTGACTTGAATGTCCAACGCAAAGCAATACATGAACTCATCCAAGTGATG
GCTGAACTGTCGCCAGCAGCTAAAACAGGGAAGCGAAAAAGGAGTCAGATGCTGTTTCAA
GGTCGAAGAGCATCCCAGTAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
X13274

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_5_Locus:
12q14

# Macromolecular_Interacting_Partner_5_SNPs:
rs2069723; rs2069734; rs2069722; rs2234687; rs1042274; rs2069721; rs2069718; rs1861493; rs2069719; rs2069714; rs2069716; rs2069720; rs1861494; rs2069713; rs2069717; rs9282708; rs2234685; rs3087272; rs2069715; rs2069733; rs2430561; rs2193049; rs2069728; rs2069705; rs2069724; rs2069731; rs2193050; rs2069725; rs2069709; rs3181034; rs2069727; rs2069736; rs2069707; rs7956940; rs7956720; rs2069706; rs2069732; rs9282709; rs2069729; rs2069726; rs2069730; rs2069710; rs7957366; rs35040375; rs35314021; rs34079299; rs2069712; rs10611634; rs2234686; rs34399538; rs2069711; rs28910281; rs10599707; rs35008976; rs35994963; rs2069737; rs35751061; rs7956688; rs2069735; rs35815094; rs3814242; rs4394909; rs2069708; rs10878762; rs10878763; rs11177072; rs11177073; rs11177074; rs11831576; rs12306852; rs12366912; rs12369470; rs2098395; rs2111059; rs2870953; rs3181032; rs3181033; rs3181035; rs6421227; rs6581791; rs6581794; rs6581795; rs7138107; rs7139169; rs7298719; rs7302488; rs7350604; rs7968411; rs7969745

# Macromolecular_Interacting_Partner_5_General_References:
6180322; 6173769; 2860101; 6329718; 6176945; 6427223; 3109913; 2504704; 1902591; 7617032; 10860730; 1525157

# Macromolecular_Interacting_Partner_5_References:
2120210; 2511835; 8314853; 8724983

# Macromolecular_Interacting_Partner_6_ID:
5319

# Macromolecular_Interacting_Partner_6_Name:
Tyrosinase precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
Monophenol monooxygenase; Tumor rejection antigen AB; SK29-AB; LB24-AB

# Macromolecular_Interacting_Partner_6_Gene_Name:
TYR

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Tyrosinase precursor
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILL
SNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVR
RNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMH
YYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRD
AEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRN
PGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQS
SMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGH
NRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLG
AAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
529

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
60394

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
6.05

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone

# Macromolecular_Interacting_Partner_6_Pathway:
map00350  Tyrosine metabolism;
 map00740  Riboflavin metabolism;
 map00940  Stilbene, coumarine and lignin biosynthesis;
 map00950  Alkaloid biosynthesis I

# Macromolecular_Interacting_Partner_6_Reaction:
L-tyrosine + L-dopa + O2 = L-dopa + dopaquinone + H2O

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00264:Tyrosinase

# Macromolecular_Interacting_Partner_6_Signals:
1-18

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
477-497

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
EC 1.14.18.1

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
340037

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
TYRO_HUMAN (P14679)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
TYR

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
TYR

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:12442

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Melanosome; melanosomal membrane; single- pass type I membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1590 bp
ATGCTCCTGGCTGTTTTGTACTGCCTGCTGTGGAGTTTCCAGACCTCCGCTGGCCATTTC
CCTAGAGCCTGTGTCTCCTCTAAGAACCTGATGGAGAAGGAATGCTGTCCACCGTGGAGC
GGGGACAGGAGTCCCTGTGGCCAGCTTTCAGGCAGAGGTTCCTGTCAGAATATCCTTCTG
TCCAATGCACCACTTGGGCCTCAATTTCCCTTCACAGGGGTGGATGACCGGGAGTCGTGG
CCTTCCGTCTTTTATAATAGGACCTGCCAGTGCTCTGGCAACTTCATGGGATTCAACTGT
GGAAACTGCAAGTTTGGCTTTTGGGGACCAAACTGCACAGAGAGACGACTCTTGGTGAGA
AGAAACATCTTCGATTTGAGTGCCCCAGAGAAGGACAAATTTTTTGCCTACCTCACTTTA
GCAAAGCATACCATCAGCTCAGACTATGTCATCCCCATAGGGACCTATGGCCAAATGAAA
AATGGATCAACACCCATGTTTAACGACATCAATATTTATGACCTCTTTGTCTGGATGCAT
TATTATGTGTCAATGGATGCACTGCTTGGGGGATCTGAAATCTGGAGAGACATTGATTTT
GCCCATGAAGCACCAGCTTTTCTGCCTTGGCATAGACTCTTCTTGTTGCGGTGGGAACAA
GAAATCCAGAAGCTGACAGGAGATGAAAACTTCACTATTCCATATTGGGACTGGCGGGAT
GCAGAAAAGTGTGACATTTGCACAGATGAGTACATGGGAGGTCAGCACCCCACAAATCCT
AACTTACTCAGCCCAGCATCATTCTTCTCCTCTTGGCAGATTGTCTGTAGCCGATTGGAG
GAGTACAACAGCCATCAGTCTTTATGCAATGGAACGCCCGAGGGACCTTTACGGCGTAAT
CCTGGAAACCATGACAAATCCAGAACCCCAAGGCTCCCCTCTTCAGCTGATGTAGAATTT
TGCCTGAGTTTGACCCAATATGAATCTGGTTCCATGGATAAAGCTGCCAATTTCAGCTTT
AGAAATACACTGGAAGGATTTGCTAGTCCACTTACTGGGATAGCGGATGCCTCTCAAAGC
AGCATGCACAATGCCTTGCACATCTATATGAATGGAACAATGTCCCAGGTACAGGGATCT
GCCAACGATCCTATCTTCCTTCTTCACCATGCATTTGTTGACAGTATTTTTGAGCAGTGG
CTCCGAAGGCACCGTCCTCTTCAAGAAGTTTATCCAGAAGCCAATGCACCCATTGGACAT
AACCGGGAATCCTACATGGTTCCTTTTATACCACTGTACAGAAATGGTGATTTCTTTATT
TCATCCAAAGATCTGGGCTATGACTATAGCTATCTACAAGATTCAGACCCAGACTCTTTT
CAAGACTACATTAAGTCCTATTTGGAACAAGCGAGTCGGATCTGGTCATGGCTCCTTGGG
GCGGCGATGGTAGGGGCCGTCCTCACTGCCCTGCTGGCAGGGCTTGTGAGCTTGCTGTGT
CGTCACAAGAGAAAGCAGCTTCCTGAAGAAAAGCAGCCACTCCTCATGGAGAAAGAGGAT
TACCACAGCTTGTATCAGAGCCATTTATAA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
M27160

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_6_Locus:
11q14-q21

# Macromolecular_Interacting_Partner_6_SNPs:
rs33955261; rs1042602; rs1126809; rs1042608; rs4987234; rs3913543; rs3913544; rs1502267; rs3913542; rs1827430; rs1432447; rs12799137; rs2186640; rs12273884; rs6483004; rs11018524; rs12803764; rs621313; rs7358418; rs7117973; rs7929991; rs11018541; rs6483000; rs11820797; rs10765196; rs11824837; rs4753215; rs11018528; rs12420237; rs1393350; rs12804012; rs4399330; rs7108676; rs6483008; rs6483001; rs12419949; rs1939258; rs7940773; rs7945829; rs6483006; rs591260; rs574028; rs7929015; rs12419351; rs12808785; rs6483002; rs4396293; rs501301; rs3900053; rs11018530; rs7115192; rs6483007; rs7123654; rs7940760; rs10765197; rs9919559; rs3793974; rs16913104; rs1847142; rs7943909; rs16913107; rs7107143; rs17793750; rs7111110; rs12418383; rs1939253; rs4121403; rs7947262; rs2000554; rs12420674; rs12416719; rs1847134; rs12419364; rs7115568; rs11018525; rs12418646; rs7941532; rs11820635; rs7105390; rs12419262; rs16912259; rs6483003; rs2866556; rs12808381; rs7123206; rs3793976; rs10765200; rs10830241; rs12791412; rs12786274; rs16913039; rs2000553; rs7112373; rs7927996; rs7941110; rs12417182; rs12420662; rs11823675; rs10830250; rs7941686; rs12420278; rs4121401; rs7117190; rs12421397; rs4418813; rs12807810; rs12789914; rs10765198; rs10741305; rs12808354; rs12421155; rs12417077; rs12418148; rs11824443; rs10765201; rs2002720; rs1942493; rs12098971; rs12806466; rs7101897; rs1939255; rs2298458; rs17174064; rs7924589; rs11018544; rs10501700; rs12421402; rs12417632; rs3793975; rs7117826; rs10830253; rs17191474; rs12419341; rs12420348; rs594647; rs7129973; rs12280928; rs7117213; rs16912972; rs16912981; rs11018522; rs12417166; rs7103781; rs12280693; rs11820834; rs10830245; rs1939262; rs12799347; rs7933595; rs10830248; rs12808219; rs7942587; rs12421746; rs12574987; rs7940368; rs4601783; rs16913084; rs12420864; rs12419071; rs7116589; rs16913095; rs10501698; rs11018549; rs12416958; rs7925659; rs7358330; rs12270717; rs12365043; rs12421030; rs12577992; rs16912983; rs11018555; rs12793071; rs11018545; rs11018535; rs16912966; rs11828655; rs7947052; rs11828731; rs12795158; rs3936992; rs1939263; rs9919546; rs4290229; rs660491; rs10830240; rs7933594; rs16912262; rs7117255; rs11821815; rs575429; rs10830249; rs6482999; rs1074304; rs10830244; rs11018542; rs11018548; rs17793678; rs645592; rs11018553; rs12799516; rs598769; rs10765199; rs4087499; rs16913089; rs10501699; rs16913011; rs1939251; rs4753214; rs7935604; rs11018543; rs12421505; rs10830239; rs12417327; rs11018532; rs7939929; rs6415994; rs2000555; rs12795171; rs7925468; rs2155148; rs7103787; rs16913040; rs11018562; rs1939252; rs12286618; rs7116973; rs12363772; rs10830243; rs12808283; rs7943159; rs16912994; rs7116716; rs7936840; rs9736253; rs4512823; rs3936623; rs7929736; rs11018539; rs535527; rs2155149; rs2155147; rs12803765; rs877072; rs10830247; rs10830246; rs7934212; rs12417026; rs7117974; rs6485980; rs10830238; rs12799768; rs7924913; rs525883; rs12418178; rs12288824; rs12792733; rs12799349; rs4542415; rs12792959; rs1892924; rs4547091; rs1799989; rs5021654; rs7930949; rs7940945; rs28940878; rs13312744; rs13312739; rs34297847; rs34878847; rs13312741; rs28940880; rs11545463; rs13312740; rs11826502; rs11824499; rs11545464; rs28940877; rs28940879; rs36006590; rs28940876; rs28940881; rs13312743; rs1939261; rs1939260; rs35541275; rs1800421; rs13312738; rs34814690; rs11453031; rs36041295; rs1939254; rs7121593; rs34175287; rs7951381; rs11018554; rs35062445; rs34947445; rs34656455; rs11411684; rs28634864; rs11018559; rs11018540; rs34017963; rs34698766; rs2134299; rs12788302; rs35963892; rs12786392; rs11018547; rs36137175; rs1060297; rs34202080; rs12788985; rs12365772; rs12578000; rs35218219; rs12788993; rs11018560; rs4121402; rs35026809; rs35311585; rs4121397; rs5793396; rs17852431; rs36124916; rs7929045; rs4561218; rs34486762; rs34289520; rs35905469; rs34003066; rs4429061; rs34661861; rs4987235; rs12796520; rs34703992; rs28578270; rs34373463; rs11018523; rs34739346; rs12786829; rs905283; rs5793397; rs12277937; rs11018527; rs34899701; rs34429128; rs34758368; rs34773602; rs1074303; rs36055732; rs12803508; rs13312742; rs16913082; rs36007597; rs12804213; rs35654391; rs10526067; rs28620862; rs12791524; rs35555968; rs11018536; rs7396600; rs10551522; rs34876778; rs11018556; rs1783963; rs35928779; rs7946027; rs12786751; rs7924312; rs4079453; rs4087500; rs3907204; rs35930733; rs35724269; rs12804722; rs7934646; rs35477235; rs35801536; rs34425156; rs41320146; rs1939257; rs12789480; rs34675404; rs12805094; rs11018550; rs35501966; rs35514600; rs34903891; rs12803535; rs12294360; rs4512825; rs34634444; rs592486; rs17852430; rs35663695; rs10573250; rs12788260; rs35032790; rs34621048; rs12099254; rs34873297; rs694934; rs34700959; rs4611200; rs7127196; rs35103430; rs35217407; rs35464565; rs5793398; rs10547762; rs16913085; rs34422026; rs7928821; rs35222097; rs34604882; rs609630; rs12796336; rs10671315; rs35457014; rs12271965; rs7946211; rs12805443; rs35434176; rs12789834; rs4121400; rs12146614; rs35105852; rs3907205; rs35774080; rs35744603; rs1939256; rs35428928; rs648871; rs35937494; rs582480; rs12786390; rs625401; rs11018563; rs12797237; rs636613; rs12788232; rs12807511; rs35959534; rs34067617; rs36098386; rs12788214; rs35518533; rs7112858; rs5793399; rs34584385; rs35607520; rs11018557; rs12805030; rs12574349; rs2008320; rs516696; rs35526885; rs12805221; rs35342940; rs11018551; rs1847136; rs11018538; rs11018546; rs34530512; rs34857319; rs35029283; rs11018534; rs1074305; rs35523924; rs12789159; rs35300336; rs11517465; rs603082; rs34295137; rs28826427; rs34469199; rs12787683; rs35430241; rs35115224; rs35597809; rs12295166; rs4614456; rs905281; rs10583155; rs35770150; rs34754918; rs7924785; rs35581621; rs1987513; rs12786588; rs2173998; rs33998063; rs12285584; rs12805029; rs11381844; rs12099178; rs11018558; rs28625671; rs4121398; rs35531191; rs649687; rs7927845; rs34029150; rs35008750; rs7122606; rs475629; rs34865967; rs34625776; rs35549872; rs4121399; rs35764186; rs3834913; rs7483274; rs11018526; rs12786201; rs1939259; rs28625370; rs35804290; rs34388247; rs16912961; rs35195697; rs7105284; rs35638921; rs7119171; rs12364170; rs10691193; rs28521275; rs11374501; rs10830237; rs11824466; rs11827921; rs12795279; rs1954771; rs35402334; rs7949856; rs949537; rs949538

# Macromolecular_Interacting_Partner_6_General_References:
1903356; 2823263; 2499655; 1711223; 8340755; 11153699; 2480811; 2504160; 11214319; 8477259; 10094567; 2342539; 1970634; 1903591; 1642278; 1899321; 1900309; 1943686; 1487241; 7902671; 8128955; 7955413; 8644824; 9158138; 9259202; 10987646; 10571953; 11295837; 11858948

# Macromolecular_Interacting_Partner_6_References:
10643998; 16293777; 16778797; 7826365

# Macromolecular_Interacting_Partner_7_ID:
7386

# Macromolecular_Interacting_Partner_7_Name:
GTP cyclohydrolase 1 feedback regulatory protein

# Macromolecular_Interacting_Partner_7_Synonyms:
GTP cyclohydrolase I feedback regulatory protein; GFRP; p35

# Macromolecular_Interacting_Partner_7_Gene_Name:
GCHFR

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>GTP cyclohydrolase 1 feedback regulatory protein
MPYLLISTQIRMEVGPTMVGDEQSDPELMQHLGASKRRALGNNFYEYYVDDPPRIVLDKL
ERRGFRVLSMTGVGQTLVWCLHKE

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
84

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
9698

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.51

# Macromolecular_Interacting_Partner_7_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. This inhibition is reversed by L-phenylalanine

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF06399:GFRP

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
1698997

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
GFRP_HUMAN (P30047)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
GCHFR

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
GCHFR

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:4194

# Macromolecular_Interacting_Partner_7_PDB_ID:
1IS8

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>255 bp
ATGCCCTACCTGCTCATCAGCACCCAGATCCGCATGGAGGTGGGCCCCACTATGGTGGGC
GATGAACAGTCGGATCCAGAGCTGATGCAGCATCTGGGGGCTTCAAAGAGAAGAGCCTTG
GGAAACAACTTTTATGAATACTACGTCGATGACCCTCCCCGCATAGTCCTGGACAAGCTG
GAACGCAGGGGCTTCCGTGTGCTGAGCATGACGGGGGTGGGCCAGACGCTGGTGTGGTGT
CTGCACAAGGAGTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
U78190

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:15

# Macromolecular_Interacting_Partner_7_Locus:
15q15

# Macromolecular_Interacting_Partner_7_SNPs:
rs2016546; rs6492966; rs2412552; rs7182456; rs2301176; rs2412550; rs7164342; rs3759796; rs35183988; rs2898998; rs35049045; rs7182689; rs36099274; rs8042544; rs35856446; rs36031661; rs11413960; rs10600318; rs2412551; rs7163862; rs12901051; rs34211024; rs11558807; rs12442845; rs12904662; rs12911144; rs16970995; rs16970997; rs1866170; rs2004043; rs2289218; rs2289219; rs35673728; rs3784289; rs3784290; rs6492964; rs7165694; rs7166719; rs7169273; rs7172251; rs7174551; rs7174651; rs7175361; rs7175711; rs8023337; rs8025558; rs8031526; rs8035141

# Macromolecular_Interacting_Partner_7_General_References:
1286669

# Macromolecular_Interacting_Partner_7_References:
15167268; 15649650; 8702680; 9685352

# Macromolecular_Interacting_Partner_8_ID:
6226

# Macromolecular_Interacting_Partner_8_Name:
GTP cyclohydrolase I

# Macromolecular_Interacting_Partner_8_Synonyms:
GTP-CH-I

# Macromolecular_Interacting_Partner_8_Gene_Name:
GCH1

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>GTP cyclohydrolase 
IMEKGPVRAPAEKPRGARCSNGFPERDPPRPGPSRPAEKPPRPEAKSAQPADGWKGERPR
SEEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKGYQETISDVLND
AIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRL
QVQERLTKQIAVAITEALRPAGVGVVVEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPK
TREEFLTLIRS

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
250

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
27903

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
8.82

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  cyclohydrolase activity
Function:  GTP cyclohydrolase activity
Function:  GTP cyclohydrolase I activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Coenzyme transport and metabolism 

# Macromolecular_Interacting_Partner_8_Specific_Function:
Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown

# Macromolecular_Interacting_Partner_8_Pathway:
map00790  Folate biosynthesis

# Macromolecular_Interacting_Partner_8_Reaction:
GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF01227:GTP_cyclohydroI

# Macromolecular_Interacting_Partner_8_Signals:
None

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
EC 3.5.4.16

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
7242659

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
GCH1_HUMAN (P30793)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
GCH1

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
GCH1

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:4193

# Macromolecular_Interacting_Partner_8_PDB_ID:
1IS8

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>753 bp
ATGGAGAAGGGCCCTGTGCGGGCACCGGCGGAGAAGCCGCGGGGCGCCAGGTGCAGCAAT
GGGTTCCCCGAGCGGGATCCGCCGCGGCCCGGGCCCAGCAGGCCGGCGGAGAAGCCCCCG
CGGCCCGAGGCCAAGAGCGCGCAGCCCGCGGACGGCTGGAAGGGCGAGCGGCCCCGCAGC
GAGGAGGATAACGAGCTGAACCTCCCTAACCTGGCAGCCGCCTACTCGTCCATCCTGAGC
TCGCTGGGCGAGAACCCCCAGCGGCAAGGGCTGCTCAAGACGCCCTGGAGGGCGGCCTCG
GCCATGCAGTTCTTCACCAAGGGCTACCAGGAGACCATCTCAGATGTCCTAAACGATGCT
ATATTTGATGAAGATCATGATGAGATGGTGATTGTGAAGGACATAGACATGTTTTCCATG
TGTGAGCATCACTTGGTTCCATTTGTTGGAAAGGTCCATATTGGTTATCTTCCTAACAAG
CAAGTCCTTGGCCTCAGCAAACTTGCGAGGATTGTAGAAATCTATAGTAGAAGACTACAA
GTTCAGGAGCGCCTTACAAAACAAATTGCTGTAGCAATCACGGAAGCCTTGCGGCCTGCT
GGAGTCGGGGTAGTGGTTGAAGCAACACACATGTGTATGGTAATGCGAGGTGTACAGAAA
ATGAACAGCAAAACTGTGACCAGCACAATGTTGGGTGTGTTCCGGGAGGATCCAAAGACT
CGGGAAGAGTTCCTGACTCTCATTAGGAGCTGA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
Z29434

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_8_Locus:
14q22.1-q22.2

# Macromolecular_Interacting_Partner_8_SNPs:
rs841; rs17128017; rs6572984; rs10136966; rs2878168; rs8004018; rs2183081; rs8007201; rs8004445; rs4411417; rs10133662; rs7492600; rs3783638; rs3783642; rs10131232; rs8017210; rs998259; rs9671371; rs10149945; rs8009759; rs12589758; rs7147286; rs8018688; rs7147201; rs10139282; rs7147200; rs17128021; rs7156475; rs10133661; rs11848732; rs7161034; rs12587434; rs10143089; rs4462519; rs10141456; rs17128052; rs10136545; rs11626298; rs7155501; rs10498472; rs3783641; rs17128050; rs752688; rs3783637; rs12147422; rs17128028; rs10133650; rs2183082; rs10873086; rs2183084; rs10129528; rs10133941; rs17128033; rs8019824; rs17253591; rs7141433; rs9671850; rs8018355; rs12432756; rs11158027; rs8010461; rs2878169; rs10131633; rs8020798; rs10150825; rs3783640; rs3783639; rs10498471; rs10220514; rs8009470; rs10149080; rs2149482; rs11626155; rs4363780; rs10134429; rs7141319; rs11620796; rs7155099; rs17253577; rs11850691; rs12879111; rs10220342; rs7140523; rs10140721; rs7155309; rs2149483; rs1952437; rs17128057; rs11158026; rs8010282; rs10147430; rs4402455; rs10782425; rs7141483; rs8011751; rs10134163; rs10138301; rs4363781; rs10132356; rs10146658; rs11627828; rs10137504; rs10145097; rs17832263; rs10144581; rs3825611; rs12885400; rs10138429; rs17253584; rs11627767; rs10220344; rs8019791; rs10137881; rs11626210; rs10139369; rs9989242; rs2183080; rs7493025; rs9671455; rs7142517; rs17739146; rs10137071; rs3759662; rs10144972; rs11851287; rs17671485; rs10144725; rs17128008; rs3759663; rs17128011; rs11847085; rs10136972; rs41298440; rs41298432; rs41298442; rs987; rs10151500; rs1753589; rs34156666; rs28458175; rs41298438; rs34808879; rs9743836; rs10444720; rs8011712; rs34787772; rs4047209; rs8016730; rs35533684; rs35111582; rs34499089; rs13329058; rs1136927; rs11461307; rs34544088; rs35662681; rs7147040; rs11439363; rs35987298; rs10131563; rs34339930; rs10138594; rs28757745; rs12884925; rs35139021; rs35880039; rs3965763; rs34713671; rs41298436; rs11444305; rs7153566; rs35776259; rs35265487; rs28481447; rs35926285; rs10598935; rs2878170; rs34618298; rs41298426; rs10146709; rs28532361; rs10645822; rs11312854; rs10133449; rs10143025; rs34119917; rs12883072; rs7153186; rs11845055; rs2878171; rs28477407; rs36225285; rs34831360; rs35041629; rs35951874; rs3825610; rs34027548; rs34037186; rs10129468; rs35476604; rs35827455; rs34859174; rs35407542; rs34576183; rs36095464; rs8003903; rs9805909; rs35116635; rs12323905; rs3945570; rs9672037; rs28542181; rs11412107; rs28643468; rs11844799; rs34191865; rs11624963; rs13329045; rs41298430; rs28413055; rs35587902; rs36150047; rs35600814; rs9972204; rs8010689; rs35892399; rs34163543; rs2183083; rs34635384; rs2004633; rs11410453; rs10545051; rs28417208; rs41298434; rs41298428; rs3759660; rs34824784; rs11468814; rs35711887; rs3759661; rs7342548; rs11468813; rs10695628; rs10145336; rs10483639; rs11621165; rs11847771; rs1187894; rs17127998; rs17128004; rs17671345; rs17738966; rs2057368; rs2057369; rs2145945; rs2878172; rs3759664; rs3759665; rs7148831; rs8007267; rs8008858

# Macromolecular_Interacting_Partner_8_General_References:
1520321; 8695054; 1482676; 8666288; 7730309; 8068008; 9222755; 7874165; 7501255; 8957022; 8852666; 9120469; 9328244; 9667588; 9778264; 10987649; 10582612; 10208576; 10076897; 10825351; 11113234; 12391354

# Macromolecular_Interacting_Partner_8_References:
10079965; 10321973; 10496263; 10619653

# Macromolecular_Interacting_Partner_9_ID:
7682

# Macromolecular_Interacting_Partner_9_Name:
Interleukin-2 precursor

# Macromolecular_Interacting_Partner_9_Synonyms:
IL-2; T-cell growth factor; TCGF; Aldesleukin

# Macromolecular_Interacting_Partner_9_Gene_Name:
IL2

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Interleukin2 precursor
MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRML
TFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSE
TTFMCEYADETATIVEFLNRWITFCQSIISTLT

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
17628

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
7.95

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  growth factor activity
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interleukin-2 receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00715:IL2

# Macromolecular_Interacting_Partner_9_Signals:
1-20

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
5729676

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
IL2_HUMAN (P60568)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
IL2

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
IL2

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:6001

# Macromolecular_Interacting_Partner_9_PDB_ID:
1PW6

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>462 bp
ATGTACAGGATGCAACTCCTGTCTTGCATTGCACTAAGTCTTGCACTTGTCACAAACAGT
GCACCTACTTCAAGTTCTACAAAGAAAACACAGCTACAACTGGAGCATTTACTGCTGGAT
TTACAGATGATTTTGAATGGAATTAATAATTACAAGAATCCCAAACTCACCAGGATGCTC
ACATTTAAGTTTTACATGCCCAAGAAGGCCACAGAACTGAAACATCTTCAGTGTCTAGAA
GAAGAACTCAAACCTCTGGAGGAAGTGCTAAATTTAGCTCAAAGCAAAAACTTTCACTTA
AGACCCAGGGACTTAATCAGCAATATCAACGTAATAGTTCTGGAACTAAAGGGATCTGAA
ACAACATTCATGTGTGAATATGCTGATGAGACAGCAACCATTGTAGAATTTCTGAACAGA
TGGATTACCTTTTGTCAAAGCATCATCTCAACACTGACTTGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
J00264

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_9_Locus:
4q26-q27

# Macromolecular_Interacting_Partner_9_SNPs:
rs3087209; rs2069763; rs2069778; rs2069769; rs2069764; rs2069779; rs1479920; rs2069768; rs2069765; rs1479921; rs2069771; rs2069772; rs2069773; rs2069770; rs2069777; rs2069776; rs2069762; rs2067006; rs2069774; rs1479922; rs11575812; rs10019970; rs11575810; rs1051753; rs34762647; rs35084452; rs2069767; rs34501152; rs11575807; rs41304870; rs33988980; rs34863848; rs34419809; rs2448491; rs2069766; rs11575808; rs2069760; rs2069775; rs11575811; rs36215455; rs2069780; rs36215457; rs36215454; rs11575813; rs2069761; rs35007569; rs36215456; rs35104399; rs10027390; rs11932411; rs13435525; rs1479923; rs1479924; rs2219865; rs3136534; rs4833248

# Macromolecular_Interacting_Partner_9_General_References:
6330695; 6403867; 6312994; 6306584; 6608729; 6324170; 7722480; 8824916; 3264184; 3491296; 6333684; 2793860; 3500515; 1631562; 1510960; 7529123

# Macromolecular_Interacting_Partner_9_References:
1535794; 2120210; 2613745; 3490393

# Macromolecular_Interacting_Partner_10_ID:
7130

# Macromolecular_Interacting_Partner_10_Name:
Calmodulin

# Macromolecular_Interacting_Partner_10_Synonyms:
CaM

# Macromolecular_Interacting_Partner_10_Gene_Name:
CALM1

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Calmodulin
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
149

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
16838

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
3.84

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
Calmodulin mediates the control of a large number of enzymes and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00036:efhand

# Macromolecular_Interacting_Partner_10_Signals:
None

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
179888

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
CALM_HUMAN (P62158)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
CALM1

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
CALM1

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:1442

# Macromolecular_Interacting_Partner_10_PDB_ID:
1IQ5

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>450 bp
ATGGCTGACCAGCTGACTGAGGAGCAGATTGCAGAGTTCAAGGAGGCCTTCTCCCTCTTT
GACAAGGATGGAGATGGCACTATCACCACCAAGGAGTTGGGGACAGTGATGAGATCCCTG
GGACAGAACCCCACTGAAGCAGAGCTGCAGGATATGATCAATGAGGTGGATGCAGATGGG
AACGGGACCATTGACTTCCCGGAGTTCCTGACCATGATGGCCAGAAAGATGAAGGACACA
GACAGTGAGGAGGAGATCCGAGAGGCGTTCCGTGTCTTTGACAAGGATGGGAATGGCTAC
ATCAGCGCCGCAGAGCTGCGTCACGTAATGACGAACCTGGGGGAGAAGCTGACCGATGAG
GAGGTGGATGAGATGATCAGGGAGGCTGACATCGATGGAGATGGCCAGGTCAATTATGAA
GAGTTTGTACAGATGATGACTGCAAAGTGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
J04046

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_10_Locus:
14q24-q31

# Macromolecular_Interacting_Partner_10_SNPs:
rs1059296; rs3179089; rs3814843; rs5871; rs3814845; rs12886342; rs3814846; rs1058903; rs3213718; rs2300499; rs9646173; rs2300501; rs2300502; rs2268433; rs2300497; rs3729787; rs2300500; rs3213719; rs7156456; rs3729785; rs2300496; rs3729783; rs2300498; rs3759708; rs11621831; rs3814847; rs12885713; rs11541171; rs11541170; rs11287138; rs35418035; rs15414; rs12886083; rs1059285; rs3814844; rs12886186; rs11539544; rs35149335; rs11541173; rs12895206; rs33952244; rs7155325; rs3060982; rs10140889; rs41304357; rs35204775; rs28691160; rs41317298; rs34384220; rs7155363; rs35428964; rs33976329; rs34825576; rs3729786; rs41307098; rs12886752; rs28460357; rs12894793; rs34068835; rs34704743; rs5810498; rs35688922; rs4620900; rs7148581; rs34983137; rs10146938; rs10148565; rs10873403; rs11629265; rs12891145; rs17126708; rs17126717; rs17126719; rs2068086; rs2110114; rs2401887; rs2896135; rs4904687; rs6575131; rs6575134; rs7144225; rs8006462; rs876259

# Macromolecular_Interacting_Partner_10_General_References:
3182832; 2445749; 6385987; 2223880; 7925473; 9681195; 12508121; 7093203; 11807546

# Macromolecular_Interacting_Partner_10_References:
1373797; 15235013; 16300634; 7541350

# Macromolecular_Interacting_Partner_11_ID:
5672

# Macromolecular_Interacting_Partner_11_Name:
6-pyruvoyl tetrahydrobiopterin synthase

# Macromolecular_Interacting_Partner_11_Synonyms:
PTPS; PTP synthase

# Macromolecular_Interacting_Partner_11_Gene_Name:
PTS

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>6pyruvoyl tetrahydrobiopterin synthase
MSTEGGGRRCQAQVSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVH
GEIDPATGMVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFADVVSTTENVAVYIWDNLQK
VLPVGVLYKVKVYETDNNIVVYKGE

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
145

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
16386

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
6.67

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-oxygen lyase activity
Function:  carbon-oxygen lyase activity, acting on phosphates
Function:  6-pyruvoyltetrahydropterin synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  aromatic compound metabolism
Process:  aromatic compound biosynthesis
Process:  pteridine and derivative biosynthesis
Process:  tetrahydrobiopterin biosynthesis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_11_General_Function:
Coenzyme transport and metabolism 

# Macromolecular_Interacting_Partner_11_Specific_Function:
Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin

# Macromolecular_Interacting_Partner_11_Pathway:
map00790  Folate biosynthesis

# Macromolecular_Interacting_Partner_11_Reaction:
6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF01242:PTPS

# Macromolecular_Interacting_Partner_11_Signals:
None

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
EC 4.2.3.12

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
177789

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
PTPS_HUMAN (Q03393)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
PTS

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
PTS

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:9689

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>438 bp
ATGAGCACGGAAGGTGGTGGCCGTCGCTGCCAGGCACAAGTGTCCCGCCGCATCTCCTTC
AGCGCGAGCCACCGATTGTACAGTAAATTTCTAAGTGATGAAGAAAACTTGAAACTGTTT
GGGAAATGCAACAATCCAAATGGCCATGGGCACAATTATAAAGTTGTGGTGACAGTACAT
GGAGAGATTGACCCTGCTACGGGAATGGTTATGAATCTGGCTGATCTCAAAAAATATATG
GAGGAGGCGATTATGCAGCCCCTTGATCATAAGAATCTGGATATGGATGTGCCATACTTT
GCAGATGTGGTGAGCACGACTGAAAATGTAGCTGTTTATATCTGGGACAACCTCCAGAAA
GTTCTTCCTGTAGGAGTTCTTTATAAAGTAAAAGTATACGAAACTGACAATAATATTGTG
GTTTATAAAGGAGAATAG

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
M97655

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_11_Locus:
11q22.3-q23.3

# Macromolecular_Interacting_Partner_11_SNPs:
rs3819331; rs2518351; rs2676374; rs2518352; rs2564862; rs2518348; rs2564865; rs2564864; rs2564863; rs17851590; rs11541630; rs1126546; rs3211484; rs35196884; rs1139452; rs3018472; rs2564861; rs5794785; rs35989206; rs2676373; rs2518353; rs2518350; rs34252028; rs2904867; rs12291869; rs2518349; rs12291603; rs4025978; rs2435289; rs2676375; rs34457986; rs2435290; rs7945257; rs10690183; rs11464665; rs2019209; rs4369441; rs34155806; rs7105071; rs1154763; rs12293583; rs1367038; rs1811350; rs2217401; rs2518345; rs2518346; rs2518347; rs2676377; rs2904868; rs35082717; rs3758876; rs7110251; rs7938116; rs7941336; rs919479; rs957090; rs975020

# Macromolecular_Interacting_Partner_11_General_References:
1282802; 8216273; 7698774; 8841415; 10531334; 9222755; 8178819; 7493990; 8707300; 9222757; 9159737; 9450907; 10220141

# Macromolecular_Interacting_Partner_11_References:
10321973; 10987137; 14729142; 7698774

# Macromolecular_Interacting_Partner_12_ID:
8080

# Macromolecular_Interacting_Partner_12_Name:
Beta-nerve growth factor precursor

# Macromolecular_Interacting_Partner_12_Synonyms:
Beta-NGF

# Macromolecular_Interacting_Partner_12_Gene_Name:
NGFB

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Betanerve growth factor precursor
MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIA
ARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSK
RSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCR
DPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRR
A

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
241

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
26959

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
10.54

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF00243:NGF

# Macromolecular_Interacting_Partner_12_Signals:
1-18

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
671883

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
NGF_HUMAN (P01138)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
NGFB

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
NGFB

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:7808

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>726 bp
ATGTCCATGTTGTTCTACACTCTGATCACAGCTTTTCTGATCGGCATACAGGCGGAACCA
CACTCAGAGAGCAATGTCCCTGCAGGACACACCATCCCCCAAGTCCACTGGACTAAACTT
CAGCATTCCCTTGACACTGCCCTTCGCAGAGCCCGCAGCGCCCCGGCAGCGGCGATAGCT
GCACGCGTGGCGGGGCAGACCCGCAACATTACTGTGGACCCCAGGCTGTTTAAAAAGCGG
CGACTCCGTTCACCCCGTGTGCTGTTTAGCACCCAGCCTCCCCGTGAAGCTGCAGACACT
CAGGATCTGGACTTCGAGGTCGGTGGTGCTGCCCCCTTCAACAGGACTCACAGGAGCAAG
CGGTCATCATCCCATCCCATCTTCCACAGGGGCGAATTCTCGGTGTGTGACAGTGTCAGC
GTGTGGGTTGGGGATAAGACCACCGCCACAGACATCAAGGGCAAGGAGGTGATGGTGTTG
GGAGAGGTGAACATTAACAACAGTGTATTCAAACAGTACTTTTTTGAGACCAAGTGCCGG
GACCCAAATCCCGTTGACAGCGGGTGCCGGGGCATTGACTCAAAGCACTGGAACTCATAT
TGTACCACGACTCACACCTTTGTCAAGGCGCTGACCATGGATGGCAAGCAGGCTGCCTGG
CGGTTTATCCGGATAGATACGGCCTGTGTGTGTGTGCTCAGCAGGAAGGCTGTGAGAAGA
GCCTGA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
V01511

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_12_Locus:
1p13.1

# Macromolecular_Interacting_Partner_12_SNPs:
rs6330; rs11466110; rs11466111; rs6325; rs1318345; rs2747058; rs719452; rs2179926; rs2254404; rs2856813; rs910330; rs2239622; rs10776800; rs2254527; rs3811015; rs4332358; rs10776798; rs4454548; rs4839028; rs4073129; rs4076194; rs4839435; rs4146585; rs6678788; rs4839436; rs6326; rs12082544; rs6328; rs6698675; rs7540561; rs6537860; rs4240542; rs7544068; rs4529705; rs7542555; rs4075872; rs11102929; rs2747063; rs10745349; rs7535026; rs10776799; rs2268792; rs6673867; rs4565713; rs4626883; rs2268793; rs4076018; rs2300692; rs6331; rs6686615; rs10858075; rs12402406; rs11466098; rs17540656; rs4573519; rs10858072; rs10489530; rs12060354; rs7516191; rs11466100; rs11102924; rs7530686; rs3730194; rs2856811; rs10776797; rs12026714; rs11102925; rs17033706; rs7513144; rs4298728; rs17033692; rs17033685; rs10442682; rs11102919; rs12067817; rs4382725; rs4567277; rs3738701; rs11102917; rs11466085; rs11102926; rs7544163; rs7523654; rs17033688; rs10858074; rs4634908; rs2300694; rs7520839; rs11466069; rs11466104; rs11466091; rs11466073; rs4240543; rs11466103; rs11466089; rs11466083; rs11466102; rs12026809; rs11102920; rs12145726; rs12048019; rs11466076; rs11102916; rs11466070; rs10442681; rs6678898; rs11466068; rs11466075; rs12061479; rs7415422; rs11466099; rs7555016; rs11466093; rs6658541; rs11466077; rs17033622; rs11466079; rs11466095; rs2300693; rs11466094; rs4623700; rs10858071; rs11466106; rs11466109; rs12058002; rs11466097; rs11466074; rs3811016; rs12061661; rs17033680; rs2300695; rs11466108; rs4644491; rs11102922; rs4406631; rs12058927; rs11466072; rs12091513; rs12060360; rs11466071; rs4298730; rs11466081; rs11466086; rs10858073; rs11466080; rs11102921; rs11102927; rs7536097; rs12760036; rs11102918; rs11466087; rs11466096; rs11466084; rs4320778; rs11584438; rs4348722; rs4456091; rs4839434; rs6329; rs7417254; rs11466088; rs10158276; rs4240544; rs11466082; rs3811014; rs10776801; rs11102930; rs11466113; rs11466066; rs11466063; rs11466065; rs11466062; rs34542615; rs28758211; rs11466112; rs34079702; rs35941329; rs11466092; rs12727497; rs35833423; rs11579116; rs35290932; rs11302114; rs2284830; rs12749420; rs3730184; rs28645283; rs2747059; rs11466090; rs35070942; rs11102923; rs12088144; rs35067920; rs11102928; rs11580846; rs35755250; rs11466107; rs34024301; rs12023088; rs28735771; rs28461336; rs11579131; rs34357271; rs34257515; rs11579114; rs35884898; rs12025459; rs12119346; rs35221274; rs35274060; rs12073677; rs12070188; rs11584424; rs35329343; rs34377570; rs11485078; rs3730215; rs35658308; rs3021067; rs4417063; rs12731678; rs2747061; rs35447405; rs12047130; rs11579133; rs13374803; rs35225488; rs9970214; rs719451; rs7528234; rs2747056; rs2856814; rs10157426; rs12731680; rs11466078; rs2747055; rs35917469; rs35011726; rs35337130; rs35044546; rs17033682; rs28505352; rs34063775; rs2856812; rs35439338; rs11466105; rs34845120; rs11586039; rs34042023; rs35071824; rs34402529; rs2747057; rs11466114; rs35603764; rs11466064; rs11466061; rs11466067; rs34611363; rs3841009; rs10776802; rs10858076; rs10858077; rs10858078; rs11102915; rs11102932; rs11466059; rs11583020; rs11805062; rs11807499; rs12074502; rs12075799; rs12085129; rs12139760; rs12723944; rs1474798; rs1535093; rs1555207; rs17033589; rs17033597; rs17033602; rs17033725; rs2068797; rs2982740; rs2982741; rs2982742; rs3014804; rs4073110; rs4131272; rs4131273; rs4310443; rs4418592; rs4504888; rs4839029; rs4839030; rs4839031; rs6327; rs6656381; rs6657711; rs6676284; rs6678944; rs6691765; rs7416420; rs7523086; rs7523831; rs7532754; rs7544256; rs926781

# Macromolecular_Interacting_Partner_12_General_References:
6688123; 6327169; 2374737; 10322959; 2025430; 10391209

# Macromolecular_Interacting_Partner_12_References:
10197775; 11716480; 8724983; 9383205

# Macromolecular_Interacting_Partner_13_ID:
8452

# Macromolecular_Interacting_Partner_13_Name:
Lymphotoxin-beta

# Macromolecular_Interacting_Partner_13_Synonyms:
LT-beta; Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3

# Macromolecular_Interacting_Partner_13_Gene_Name:
LTB

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Lymphotoxinbeta
MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD
PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS
DAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLE
GAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGA
VMVG

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
244

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
25390

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
5.02

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_13_Signals:
1-35

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
292279

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
TNFC_HUMAN (Q06643)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
LTB

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
LTB

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:6711

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>735 bp
ATGGGGGCACTGGGGCTGGAGGGCAGGGGTGGGAGGCTCCAGGGGAGGGGTTCCCTCCTG
CTAGCTGTGGCAGGAGCCACTTCTCTGGTGACCTTGTTGCTGGCGGTGCCTATCACTGTC
CTGGCTGTGCTGGCCTTAGTGCCCCAGGATCAGGGAGGACTGGTAACGGAGACGGCCGAC
CCCGGGGCACAGGCCCAGCAAGGACTGGGGTTTCAGAAGCTGCCAGAGGAGGAGCCAGAA
ACAGATCTCAGCCCCGGGCTCCCAGCTGCCCACCTCATAGGCGCTCCGCTGAAGGGGCAG
GGGCTAGGCTGGGAGACGACGAAGGAACAGGCGTTTCTGACGAGCGGGACGCAGTTCTCG
GACGCCGAGGGGCTGGCGCTCCCGCAGGACGGCCTCTATTACCTCTACTGTCTCGTCGGC
TACCGGGGCCGGGCGCCCCCTGGCGGCGGGGACCCCCAGGGCCGCTCGGTCACGCTGCGC
AGCTCTCTGTACCGGGCGGGGGGCGCCTACGGGCCGGGCACTCCCGAGCTGCTGCTCGAG
GGCGCCGAGACGGTGACTCCAGTGCTGGACCCGGCCAGGAGACAAGGGTACGGGCCTCTC
TGGTACACGAGCGTGGGGTTCGGCGGCCTGGTGCAGCTCCGGAGGGGCGAGAGGGTGTAC
GTCAACATCAGTCACCCCGATATGGTGGACTTCGCGAGAGGGAAGACCTTCTTTGGGGCC
GTGATGGTGGGGTGA

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
L11016

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_13_Locus:
6p21.3

# Macromolecular_Interacting_Partner_13_SNPs:
Not Available

# Macromolecular_Interacting_Partner_13_General_References:
7916655; 9299492; 10202016

# Macromolecular_Interacting_Partner_13_References:
15132301; 16052472; 2124251; 8809061

End of HMDB00027

Beginning of HMDB00030
# Accession_No:
HMDB00030

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-25 16:40:10

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Biotin

# Description:
A water-soluble, enzyme co-factor present in minute amounts in every living cell. Biotin is also known as vitamin H or B7 or coenzyme R. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. Biotin is important in the catalysis of essential metabolic reactions to synthesize fatty acids, in gluconeogenesis, and to metabolize leucine.

# Synonyms:
(+)-Biotin; (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valerate; (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid; (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valerate; (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid; 5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate; 5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid; Biodermatin; Bioepiderm; Bios II; Biotin; Coenzyme R; D(+)-Biotin; D-(+)-Biotin; D-Biotin; Factor S; Injacom H; Lutavit H2; Meribin; Rovimix H 2; Vitamin B7; Vitamin H; cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valerate; cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid; hexahydro-2-oxo-[3aS-(3aa,4b,6aa)]-1H-Thieno[3,4-d]imidazole-4-pentanoate; hexahydro-2-oxo-[3aS-(3aa,4b,6aa)]-1H-Thieno[3,4-d]imidazole-4-pentanoic acid; hexahydro-2-oxo-[3as-(3alpha,4beta,6alpha)]-1H-Thieno[3,4-d]imidazole-4-pentanoate; hexahydro-2-oxo-[3as-(3alpha,4beta,6alpha)]-1H-Thieno[3,4-d]imidazole-4-pentanoic acid; delta-(+)-Biotin; delta-Biotin

# Chemical_IUPAC_Name:
5-(3-oxo-7-thia-2,4-diazabicyclo[3.3.0]oct-6-yl)pentanoic acid

# Chemical_Formula:
C10H16N2O3S

# Chemical_Structure:
tbl_chemical:::HMDB00030_ZOOM.png:::119283140313715170

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00030_THUMB.png:::119283140105387587

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Vitamins

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
thioether; carboxylic acid; urea; heterocyclic compound

# Taxonomy_Biofunction:
Essential vitamins; Component of Biotin metabolism

# Taxonomy_Source:
Exogenous

# Molecular_Weight:
244.08817

# Molecular_Weight_Avg:
244.31064

# Smiles_String_isomeric:
OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12

# Smiles_String_canonical:
OC(=O)CCCCC1SCC2NC(=O)NC12

# KEGG_Compound_ID:
C00120

# BioCyc_ID:
BIOTIN

# PubChem_CID:
171548

# PubChem_SID:
826666; 834755; 10257672; 11486051; 7886365; 825094; 827176; 834758; 11108080; 8022850; 584877; 11466446; 6435802; 835031; 827863; 832719; 826557; 8143739; 826027; 834756; 11467566; 3139816; 838743; 749077; 834754; 842100; 832717; 8023123; 832726; 834757; 835033; 835030; 835032; 832718; 837148; 7853818; 832727; 819610; 832672; 7847097; 8028514; 11110441; 832725; 832724; 822205; 827480; 3420; 6435803; 827375; 834417; 832721

# OMIM_ID:
245400; 253260; 253270; 606054; 607483

# Metagene_ID:
Not Available

# BiGG_ID:
33931

# Wikipedia_ID:
Biotin

# METLIN_ID:
243

# Ref_ID:
10215065; 9022537; 9416479; 9164991; 1814646; 8750932; 2100006; 9176832; 16704206; 10064317; 9371938; 11481419; 12070309; 9038855; 15863846; 8333586; 9094878; 12603856

# ChEBI_ID:
15956

# CAS_Registry_Number:
58-85-5

# InChI:
InChI=1/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1

# Synthesis_Reference:
A simple and enantioselective synthesis of (+)-biotin.     Corey, E. J.; Mehrotra, Mukund M.    Dep. Chem.,  Harvard Univ.,  Cambridge,  MA,  USA.    Tetrahedron Letters  (1988),  29(1),  57-60.

# Melting_Point:
232 oC

# Melting_Point_predicted:
115.8 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.22 mg/mL [MERCK INDEX (1996)]; 3 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
1.22 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
0.17 [Predicted by ALOGPS]; 0.5 [Predicted by PubChem via XLOGP]; 0.39 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Biotin.pdf:::1132562190595561203

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Biotin.mol:::1132723802281899699

# SDF_File_[Text]:
tbl_chemical:::HMDB00030.sdf:::119283139650431089

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00030.pdb:::119283139937613853

# PDB_ID:
1AVD

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1AVD.txt:::1132720899156149950

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Biotin.gif:::1132732100125843078

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00030_peaks.txt:::1156309496593954220

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Biotin_C.gif:::1132737660572611528

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00030_peaks.txt:::1156310688415907109

# Mass_Spectrum:
tbl_chemical:::HMDB00030.jpg:::1132798875312425422

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000227.png:::116907444976571912

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000227.txt:::116907444976516942

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000227.png:::116890832115662321

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000227.txt:::116890832143779875

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria; nucleus

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	0.049 +/- 0.035	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	1814646
Urine	0.023 (0.013-0.032)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9022537
Blood	0.0034 (0.002 - 0.0051)	umol/L	Newborn:0-30_days_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	0.0016 (0.0009 - 0.0028)	umol/L	Children:1-13_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	0.0024 (0.0008 - 0.0041)	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	0.0012 +/- 0.00067	umol/L	Adult:>18_yrs_old	Both	Normal	1814646 


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Acariasis; Biotin deficiency; Biotin Deficiency Results in Mental Changes (Depression, Hallucinations), Paresthesia, Anorexia, and Nausea; Biotinidase Deficiency; Squamous Carcinoma

# Pathway_Names:
Fatty acid biosynthesis (path 1);Tetracycline biosynthesis;Pyruvate metabolism;Propanoate metabolism;Valine, leucine and isoleucine degradation;Alanine and aspartate metabolism;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
;;;;valine,leucine,and_isoleucine_degradation.jpg;Aspartate_and_Alanine_metabolism.jpg;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00061;map00253;map00620;map00640;map00280;map00252;map00280;map00280

# Pathway_Graphs:
;;;;valine,leucine,and_isoleucine_degradation_Graph.jpg;Aspartate_and_Alanine_metabolism_Graph.jpg;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
;;;;valine,leucine,and_isoleucine_degradation.xml;Aspartate_and_Alanine_metabolism.xml;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5247

# Metabolic_Enzyme_1_Name:
Acetyl-CoA carboxylase 2

# Metabolic_Enzyme_1_Synonyms:
ACC-beta[Includes: Biotin carboxylase

# Metabolic_Enzyme_1_Gene_Name:
ACACB

# Metabolic_Enzyme_1_Protein_Sequence:
>AcetylCoA carboxylase 2
MVLLLCLSCLIFSCLTFSWLKIWGKMTDSKPITKSKSEANLIPSQEPFPASDNSGETPQR
NGEGHTLPKTPSQAEPASHKGPKDAGRRRNSLPPSHQKPPRNPLSSSDAAPSPELQANGT
GTQGLEATDTNGLSSSARPQGQQAGSPSKEDKKQANIKRQLMTNFILGSFDDYSSDEDSV
AGSSRESTRKGSRASLGALSLEAYLTTGEAETRVPTMRPSMSGLHLVKRGREHKKLDLHR
DFTVASPAEFVTRFGGDRVIEKVLIANNGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVT
PEDLKANAEYIKMADHYVPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASENPKL
PELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGK
RISVPEDVYDKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQV
QSEIPGSPIFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAP
LAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNL
PAAQLQIAMGVPLHRLKDIRLLYGESPWGVTPISFETPSNPPLARGHVIAARITSENPDE
GFKPSSGTVQELNFRSSKNVWGYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVA
LKELSIRGDFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQAEKPDIMLGVVCGAL
NVADAMFRTCMTDFLHSLERGQVLPADSLLNLVDVELIYGGVKYILKVARQSLTMFVLIM
NGCHIEIDAHRLNDGGLLLSYNGNSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSP
SAGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRPGAVLEAGCVVAR
LELDDPSKVHPAEPFTGELPAQQTLPILGEKLHQVFHSVLENLTNVMSGFCLPEPVFSIK
LKEWVQKLMMTLRHPSLPLLELQEIMTSVAGRIPAPVEKSVRRVMAQYASNITSVLCQFP
SQQIATILDCHAATLQRKADREVFFINTQSIVQLVQRYRSGIRGYMKTVVLDLLRRYLRV
EHHFQQAHYDKCVINLREQFKPDMSQVLDCIFSHAQVAKKNQLVIMLIDELCGPDPSLSD
ELISILNELTQLSKSEHCKVALRARQILIASHLPSYELRHNQVESIFLSAIDMYGHQFCP
ENLKKLILSETTIFDVLPTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRQLPDGTCV
VEFQFMLPSSHPNRMTVPISITNPDLLRHSTELFMDSGFSPLCQRMGAMVAFRRFEDFTR
NFDEVISCFANVPKDTPLFSEARTSLYSEDDCKSLREEPIHILNVSIQCADHLEDEALVP
ILRTFVQSKKNILVDYGLRRITFLIAQEKEFPKFFTFRARDEFAEDRIYRHLEPALAFQL
ELNRMRNFDLTAVPCANHKMHLYLGAAKVKEGVEVTDHRFFIRAIIRHSDLITKEASFEY
LQNEGERLLLEAMDELEVAFNNTSVRTDCNHIFLNFVPTVIMDPFKIEESVRYMVMRYGS
RLWKLRVLQAEVKINIRQTTTGSAVPIRLFITNESGYYLDISLYKEVTDSRSGNIMFHSF
GNKQGPQHGMLINTPYVTKDLLQAKRFQAQTLGTTYIYDFPEMFRQALFKLWGSPDKYPK
DILTYTELVLDSQGQLVEMNRLPGGNEVGMVAFKMRFKTQEYPEGRDVIVIGNDITFRIG
SFGPGEDLLYLRASEMARAEGIPKIYVAANSGARIGMAEEIKHMFHVAWVDPEDPHKGFK
YLYLTPQDYTRISSLNSVHCKHIEEGGESRYMITDIIGKDDGLGVENLRGSGMIAGESSL
AYEEIVTISLVTCRAIGIGAYLVRLGQRVIQVENSHIILTGASALNKVLGREVYTSNNQL
GGVQIMHYNGVSHITVPDDFEGVYTILEWLSYMPKDNHSPVPIITPTDPIDREIEFLPSR
APYDPRWMLAGRPHPTLKGTWQSGFFDHGSFKEIMAPWAQTVVTGRARLGGIPVGVIAVE
TRTVEVAVPADPANLDSEAKIIQQAGQVWFPDSAYKTAQAIKDFNREKLPLMIFANWRGF
SGGMKDMYDQVLKFGAYIVDGLRQYKQPILIYIPPYAELRGGSWVVIDATINPLCIEMYA
DKESRGGVLEPEGTVEIKFRKKDLIKSMRRIDPAYKKLMEQLGEPDLSDKDRKDLEGRLK
AREDLLLPIYHQVAVQFADFHDTPGRMLEKGVISDILEWKTARTFLYWRLRRLLLEDQVK
QEILQASGELSHVHIQSMLRRWFVETEGAVKAYLWDNNQVVVQWLEQHWQAGDGPRSTIR
ENITYLKHDSVLKTIRGLVEENPEVAVDCVIYLSQHISPAERAQVVHLLSTMDSPAST

# Metabolic_Enzyme_1_Number_of_Residues:
2458

# Metabolic_Enzyme_1_Molecular_Weight:
276558

# Metabolic_Enzyme_1_Theoretical_pI:
6.46

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  ligase activity
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions:biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase

# Metabolic_Enzyme_1_Pathway:
map00061  Fatty acid biosynthesis (path 1);
 map00253  Tetracycline biosynthesis;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_1_Reaction:
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF08326:ACC_central;
PF02785:Biotin_carb_C;
PF00364:Biotin_lipoyl;
PF01039:Carboxyl_trans;
PF00289:CPSase_L_chain;
PF02786:CPSase_L_D2

# Metabolic_Enzyme_1_Signals:
1-24

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 6.4.1.2;EC 6.3.4.14

# Metabolic_Enzyme_1_GenBank_ID_Protein:
2138330

# Metabolic_Enzyme_1_SwissProt_ID:
COA2_HUMAN (O00763)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ACACB

# Metabolic_Enzyme_1_Geneatlas_id:
ACACB

# Metabolic_Enzyme_1_hgnc_id:
HGNC:85

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Intracytoplasmic membrane. Note=May associate with membranes

# Metabolic_Enzyme_1_Gene_Sequence:
>7452 bp
ATGGTCTTGCTTCTTTGTCTATCTTGTCTGATTTTCTCCTGTCTGACCTTTTCCTGGTTA
AAAATCTGGGAGAAAATGACGGACTCCAAGCCGATCACCAAGAGTAAATCAGAAGCAAAC
CTCATCCCGAGCCAGGAGCCCTTTCCAGCCTCTGATAACTCAGGGGAGACACCGCAGAGA
AATGGGGAGGGCCACACTCTGCACAAAGACACCCAGCCAGGCCGAGCCCAGCCTCCCACA
AAGGCCCAAAGATCCGGTCGGCGGAGAAACTCCCTACCACCCTCCCGCCAGAAGCCCCCA
AGAAACCCCCTTTCTTCCAGTGACGCAGCACCCTCCCCAGAGCTTCAAGCCAACGGGACT
GGGACACAAGGTCTGGAGGCCACAGATACCAATGGCCTGTCCTCCTCAGCCAGGCCCCAG
GGCAGCAAGCTGGTCCCCTCCAAAGAAGACAAGAAGCAGGCAAACATCAAGAGGCAGCTG
ATGACCAACTTCATCCTGGGCTCTTTTGATGACTACTCCTCCGACGAGGACTCTGTTGCT
GGCTCATCTCGTGAGTCTACCCGGAAGGGCAGCCGGGCCAGCTTGGGGGCCCTGTCCCTG
GAGGCTTATCTGACCACAGGTGAAGCTGAGACCCGCGTCCCCACTATGAGGCCGAGCATG
TCGGGACTCCACCTGGTGAAGAGGGGACGGGAACACAAGAAGCTGGACCTGCACAGAGAC
TTTACCGTGGCTTCTCCCGCTGAGTTTGTCACACGCTTTGGGGGGGATCGGGTCATCGAG
AAGGTGCTTATTGCCAACAACGGGATTGCCGCTGTGAAGTGCATGCGCTCCATCCGCAGG
TGGGCCTATGAGATGTTCCGCAACGAGCGGGCCATCCGGTTTGTTCGCATGGTGACCCCC
GAGGACCTTAAGGCCAACGCAGAGTACATCAAGATGGCGGATCATTACGGGCCCGCCCCA
GGAGGGCCCAATAACAACAACTATGCCAACGTGGAGCTGATTGTGGACATTGCCAAGAGA
ATCCCGTTGCAGGCGGTGTGGGCTGGCTGGGGCCATGCTTTAGAAAACCCTAAACTTCCG
GAGCTGCTGTGCAAGAATGGAGTTGCTTTCTTAGGCCCTCCCAGGTTGAGGCCAATGGTG
GGTCTAGGAGATAAGATCGCCTCCACCGTTGTCGCCCAGACGCTACAGGTCCCAACCCTG
CCCAGGAGTGGAAGCGCCCTGACAGTGGAGTGGACAGAAGATGATCTGCAGCAGGGAAAA
AGAATCAGTGTCCCAGAAGATGTTTATGACAAGGGTTGCGTGAAAGACGTAGATGAGGGC
TTGGAGGCAGCAGAAAGAATTGGTTTTCCATTGATGATCAAAGCTTCTGAAGGTGGCGGA
GGGAAGGGAATCCGGGAAACTGAGAGTGCGGAGGACTTCCCGATCCTTTTCAGACAAGTA
CAGAGTGAGATCCCAGGCTCGCCCATCTTTCTCATGAAGCTGGCCCAGCACGCCCGTCAC
CTGGAAGTTCAGATCCTCGCTGACCAGTATGGGAATGCTGTGTCTCTGTTTGGTCGCGAC
TGCTCCATCCAGCGGCGGCATCAGAAGATCGTTGAGGAAGCACCGGCCACCATCGCGCCG
CTGGCCATATTCGAGTTCATGGAGCAGTGTGCCATTCGCCTGGCCAAGACCGTGGGCTAT
GTGAGTGCAGGGACAGTGGAATACCTCTATAGTCAGGATGGTAGCTTCCACTTCTTGGAG
CTGAATCCTCGCTTGCAGGTGGAACATCCCTGCACAGAAATGATTGCTGACGTTAATCTG
CCGGCCGCCCAGCTACAGATCGCCATGGGTGCCCCACTGCACCGGCTGAAAGATATCCGG
CTTCTGTATGGAGAGTCACCCTGGGGAGACTCCCCAATTTCTTTTGAAAACTCAGCTCAT
CTCCCCTGCCCCCGAGGCCACGTCATTGCCACCAGAATCACCAGCGAAAACCCAGACGAG
GGTTTTAAGCCGAGCTCCGGGACTGTCCAGGAACTGAATTTCCGGAGCAGCAAGAACGTC
TGGGGTTACTTCACGGTGGCCGCTACTGGAGGCCTGCACGAGTTTGCGATTTCCCAGTTT
GGGCACTGCTTCTCCTGGGGAGAGAACCGGAAAGAGGCCATTTCGAACATGGTGGTGGCT
TTGAAGGAACTGTCCCTCCGAGGCGACTTTAGGACTACCGTGGAATACCTCATTAACCTC
CTGGAGACCGAGAGCTTCCAGAACAACTACATCGACACCGGGTGGTTGGACTACCTCATT
GCTGAGAAAGTGCAAAAGAAACCGAATATCATGCTTGGGGTGGTATGCGGGGCCCTTGAA
CGTGGAGATGCGATGTTCAGAACGTGCATGACAGATTTCTTACACTCCCTGGAAAGGGGC
CAGGTCCTCCCAGCGGATTCACTACTGAACCTCGTAGATGTGGAATTAATTTACGAGGGT
GTAAAGTACATTCTAAAGGTGACCCGGCAGTCTCTGACCATGTTCGTTCTCATCATGAAT
GGCTGCCACATCGAGATTGATGCCCACCGGCTGAATGATGGGGGGCTCCTGCTCTCCTAC
AATGGGAACAGCTACACCACCTACATGAAGGAAGAGGTTGACAGTTACCGTACCATCGGC
AATAAGACGTGTGTTTTTGAGAAGGAGAACGATCCTACAGTCCTGAGATCCCCCTCGGCT
GGGAAGCTGACACAGATCACAGTGGAGGATGGGGGCCACGTTGAGGCTGGGAGACGCTAC
GCTGAGATGGAGGTGATGAAGATGATCATGACCCTGAACGTTCAGGAAAGAGGCCGGGTG
AAGTACATCAAGCGTCCAGGTGCGGTGCTGGAAGCAGGCTGCGTGGTGGCCAGGCTGGAG
CTCGATGACCCTTCTAAAGTCCACCCGGCTGAACCGTTCACAGGAGAACTCCCTGCCCAG
CAGAACACTGCCGACCTCGGAAAGAAACTGCACAGGGTCTTCCACAGCGTCCTGGGAAGC
CTCACCAACGTCATGAGTGGCTTTTGTCTGCCAGAGCCGTTTTTTAGCATAAAGCTGAAG
GAGTGGGTGCAGAAGCTCATGATGACCCTCCGGCACCCGTCACTGCTGCTGGACGTGCAG
GAGATCATGACCAGTCGTGCAGGCCGCATCCCCCCCCCTGTTGAGAAGTCTGTCCGCAAG
GTGATGGCCCAGTATGCCAGCAACATCACCTCGGTGCTGTGCCAGTTCCCCAGCCAGCAG
ATAGCCACCATCCTGGACTGCCATGCAGCCACCCTGCAGCGGAAGGCTGATCGAGAGGTC
TTCTTCATCAACACCCAGAGCATGGTGCAGTTGGTCCAGAGGTACCGAAGTGGAATCCGC
GGTCATATGAAAACAGTGGTGATCGATCTCTTGAGAAGATACTTGCGTGTTGAGACCATT
TTCGGCAAGGCAAGAGATGCTGATGCCAACTCCAGTGGGATGGTGGGGGGCGTGAGGAGC
CTGAGCTTTACCTCTGTGTGGGTGGTTTTGTCTCCCCCAGCCCACTACGACAAGTGTGTG
ATAAACCTCAGGGAACAGTTCAAGCCAGACATGTCCCAGGTGCTGGACTGCATCTTCTCC
CACGCACAGGTGACCAAGAAGAACCAGCTGGTGATCATGTTGATCGATGAGCTGTGTGGC
CCAGACCCTTCCCTGTCGGACGAGCTGATCTCCATCCTCAACGAGCTCACTCAGCTGAGC
AAAAGCGAGCACTGCAAAGTGGCCCTCAGAGCCCGGCAGATCCTGATCGCCTCCCCCTCC
TACGAGCTGCGGCATAACCAGGTGGAGTCCATTTTCCTGTCTGCCATTGACATGTACGGC
CACCAGTTCTGCCCCGAGAACCTCCAGAAATTAATACTTTCGGAAACAACCATCTTCGAC
GTCCTGAATACTTTCTTCTATCACGCAAACAAAGTCGTGTGCATGGCGTCCTTGGAGGTT
TACGTGGGGGGGGCTTACATCGCCTATGTGTTAAACAGCCTGCAGCACCGGCAGCTCCCG
GACGGCACCTGCGTGGTAGAATTCCAGTTCATGCTGCCGTCCTCCCACCCAAACCGGATG
ACCGTGCCCATCAGCATCACCAACCCTGACCTGCTGAGGCACACGACAGAGCTCTTCATG
GACAGCGGCTTCTCCCCACTGTGCCAGCGCATGGGAGCCATGGTAGCCTTCAGGAGATTC
GAGGACTTCACCAGAAATTTTGATGAAGTCATCTCTTGCTTCGCCAACGTGCCGAAAGAC
CCCCCCCTCTTCAGCGAGGCCCGCACCTCCCTATACTCCGAGGATGACTGCAAGAGCCTC
AGAGAAGAGCCCATCCACATTCTGAATGTGTCCATCCAGTGTGCGGACCACCTGGAGGAT
GAGGCACTGGTGCCGATTTTACGTACATTCGTACAGTCCAAGAAAAATATCCTTGTGGAT
TATGGACTCCGACGAATCCCATTCTTGATTGCCCAAGAGAAAGAATTTCCCAAGTTTTTC
ACATTCAGAGCAAGAGATGAGTTTGCAGAAGATCGCATTTACCGTCACTTGGAACCTGCC
CTGGCTTTCCAGCTGGAACTCAACCGGATGCGTAACTTCGATCTGACCGCCGTGCCCTGT
GCCAACCACAAGATGCACCTTTACCTGGGTGCTGCCAAGGTGGAAGGAAGGTATGAAGTG
ACGGACCATAGGTTCTTCATCCGTGCCATCATCAGGCACTCTGACCTGATCACAAAGGAA
GCCTCCTTCGAATACCTGCAGAACGAGGGTGAGCGGCTGCTCCTGGAGGCCATGGACGAG
CTGGAGGTGGCGTTCAATAACACCAACGTGCGCACCGACTGCAACCACATCTTCCTCAAC
TTCGTGCCCACTGTCATCATGGACCCCAACAAGATCGAGGAGTCCGTGCGCTACATGGTT
ATGCGCTACGGCAGCCGGCTGTGGAAACTCCGTGTGCTACAGGCTGAGGTCAAGATCAAC
ATCCGCCAGACCACCACCGGCAGTGCCGTTCCCATCCGCCTGTTCATCACCAATGAGTCG
GGCTACTACCTGGACATCAGCCTCTACAAAGAAGTGACTGACTCCAGATCTGGAAATATC
ATGTTTCACTCCTTCGGCAACAAGCAAGGGCCCCAGCACGGGATGCTGATCAATACTCCC
TACGTCACCAAGGATCTGCTCCAGGCCAAGCGATTCCAGGCCCAGACCCTGGGAACCACC
TACATCTATGACTTCCCGGAAATGTTCAGGCAGGCTCTCTTTAAACTGTGGGGCTCCCCA
GACAAGTATCCCAAAGACATCCTGACATACACTGAATTAGTGTTGGACTCTCAGGGCCAG
CTGGTGGAGATGAACCGACTTCCTGGTGGAAATGAGGTGGGCATGGTGGCCTTCAAAATG
AGGTTTAAGACCCAGGAGTACCCGGAAGGACGGGATGTGATCGTCATCGGCAATGACATC
ACCTTTCGCATTGGATCCTTTGGCCCTGGAGAGGACCTTCTGTACCTGCGGGCATCCGAG
ATGGCCCGGGCAGAGGCGATTCCCAAAATTTACGTGGCAGCCAACAGTGGCGCCCGTATT
GGCATGGCAGAGGAGATCAAACACATGTTCCACGTGGCTTGGGTGGACCCAGAAGACCCC
CACAAAGGATTTAAATACCTGTACCTGACTCCCCAAGACTACACCAGAATCAGCTCCCTG
AACTCCGTCCACTGTAAACACATCGAGGAAGGAGGAGAGTCCAGATACATGATCACGGAT
ATCATCGGGAAGGATGATGGCTTGGGCGTGGAGAATCTGAGGGGCTCAGGCATGATTGCT
GGGGAGTCCTCTCTGGCTTACGAAGAGATCGTCACCATTAGCTTGGTGACCTGCCGAGCC
ATTGGGATTGGGGCCTACTTGGTGAGGCTGGGCCAGCGAGTGATCCAGGTGGAGAATTCC
CACATCATCCTCACAGGAGCAAGTGCTCTCAACAAGGTCCTGGGAAGAGAGGTCTACACA
TCCAACAACCAGCTGGGTGGCGTTCAGATCATGCATTACAATGGTGTCTCCCACATCACC
GTGCCAGATGACTTTGAGGGGGTTTATACCATCCTGGAGTGGCTGTCCTATATGCCAAAG
GATAATCACAGCCCTGTCCCTATCATCACACCCACTGACCCCATTGACAGAGAAATTGAA
TTCCTCCCATCCAGAGCTCCCTACGACCCCCGGTGGATGCTTGCAGGAAGGCCTCACCCA
ACTCTGAAGGGAACGTGGCAGAGCGGATTCTTTGACCACGGCAGTTTCAAGGAAATCATG
GCACCCTGGGCGCAGACCGTGGTGACAGGACGAGCAAGGCTTGGGGGGATTCCCGTGGGA
GTGATTGCTGTGGAGACACGGACTGTGGAGGTGGCAGTCCCTGCAGACCCTGCCAACCTG
GATTCTGAGGCCAAGATAATTCAGCAGGCAGGACAGGTGTGGTTCCCAGACTCAGCCTAC
AAAACCGCCCAGGCCATCAAGGACTTCAACCGGGAGAAGTTGCCCCTGATGATCTTTGCC
AACTGGAGGGGGTTCTCCGGTGGCATGAAAGACATGTATGACCAGGTGCTGAAGTTTGGA
GCCTACATCGTGGACGGCCTTAGACAATACAAACAGCCCATCCTGATCTATATCCGCCCT
ATGCGGGAGCTCCGGGGAGGCTCCTGGGTGGTCATAGATGCCACCATCAACCCGCTGTGC
ATAGAAATGTATGCAGACAAAGAGAGCAGGGGTGGTGTTCTGGAACCAGAGGGGACAGTG
GAGATTAAGTTCCGAAAGGAAGATCTGATAAAGTCCATGAGAAGGATCGATCCAGCTTAC
AAGAAGCTCATGGAACAGCTAGGGGAACCTGATCTCTCCGACAAGGACCGAAAGGACCTG
GAGGGCCGGCTAAAGGCTCGCGAGGACCTGCTGCTCCCCATCTACCACCAGGTGGCGGTG
CAGTTCGCCGACTTCCATGACACACCCGGCCGGATGCTGGAGAAGGGCGTCATATCTGAC
ATCCTGGAGTGGAAGACCGCACGCACCTTCCTGTATTGGCGTCTGCGCCGCCTCCTCCTG
GAGGACCAGGTCAAGCAGGAGATCCTGCAGGCCAGCGGGGAGCTGAGTCACGTGCATATC
CAGTCCATGCTGCGTCGCTGGTTCGTGGAGACGGAGGGGGCTGTCAAGGCCTACTTGTGG
GACAACAACCAGGTGGTTGTGCAGTGGCTGGAACAGCACTGGCAGGCAGGGGATGGCCCG
CGCTCCACCATCCGTGAGAACATCACGTACCTGAAGCACGACTCTGTCCTCAAGACCATC
CGAGGCCTGGTTGAAGAAAACCCCGAGGTGGCCGTGGACTGTGTGATATACCTGAGCCAG
CACATCAGCCCAGCTGAGCGGGCGCAGGTCGTTCACCTGCTGTCTACCATGGACAGCCCG
GCCTCCACCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U89344

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_1_Locus:
12q24.11

# Metabolic_Enzyme_1_SNPs:
rs2300455; rs2075260; rs16940029; rs2878960; rs11065772; rs7135947; rs3742023; rs2241220; rs4766516; rs11065765; rs2075262; rs2075263; rs12013; rs2080530; rs2066925; rs2284685; rs741402; rs34286; rs1642040; rs2300460; rs34274; rs2239607; rs2284689; rs7315465; rs4766547; rs2075258; rs2268403; rs3742026; rs2268391; rs2268389; rs2287221; rs1016331; rs4300440; rs2268392; rs2300453; rs4766565; rs34268; rs2268405; rs4766587; rs34276; rs3858707; rs4766455; rs2268393; rs6606697; rs2430683; rs2268404; rs34270; rs4766538; rs34266; rs2284695; rs12307255; rs759560; rs12818314; rs2300459; rs7974710; rs12818490; rs1654873; rs2075259; rs7974040; rs34275; rs2268400; rs6606694; rs11066004; rs2160602; rs2268390; rs3742027; rs2337855; rs2284691; rs7299171; rs7978168; rs12820677; rs4766564; rs12831686; rs2300452; rs16939985; rs10774608; rs34269; rs10849968; rs10849921; rs2284690; rs34271; rs11615824; rs7300608; rs7301145; rs34279; rs4766457; rs246090; rs2075261; rs34273; rs34267; rs2268388; rs12304751; rs246094; rs12581133; rs12304717; rs10744772; rs2300457; rs7316270; rs7358629; rs7300508; rs246095; rs11833565; rs7976552; rs11613533; rs4766506; rs2300456; rs4766494; rs7298135; rs246092; rs3753166; rs4766537; rs124549; rs2284684; rs4766444; rs7957249; rs2268387; rs246091; rs10849967; rs6606696; rs34285; rs9971877; rs2268384; rs2284693; rs16940082; rs16940038; rs10849926; rs2268399; rs2284694; rs2284686; rs4766584; rs7973985; rs4766548; rs7976245; rs12426388; rs7963249; rs2337857; rs7959681; rs2268385; rs11610260; rs4766583; rs11613784; rs2239608; rs2284700; rs34278; rs11065695; rs6606691; rs759559; rs11065800; rs7133315; rs7302945; rs12302208; rs7311180; rs4766495; rs7966218; rs2268394; rs7314964; rs2003590; rs7971400; rs11065873; rs7957340; rs12426437; rs4766445; rs10744776; rs246096; rs2067239; rs10774607; rs2284699; rs4766496; rs11065725; rs3742024; rs12426971; rs6606692; rs11065994; rs7962615; rs12817756; rs7969911; rs7966016; rs11065808; rs11065760; rs7959980; rs7138373; rs2300454; rs7313527; rs34280; rs10444495; rs7488423; rs7971878; rs7312701; rs12427317; rs7971854; rs12817739; rs12426445; rs2284687; rs2268396; rs6606698; rs2430684; rs2284697; rs34281; rs1654880; rs1654870; rs10732610; rs12824299; rs11616172; rs12297136; rs2268397; rs12823991; rs7968027; rs12425409; rs1642039; rs7295784; rs6606695; rs4766449; rs10849901; rs34708647; rs16940056; rs246089; rs7299500; rs7978359; rs12426447; rs7971745; rs34284; rs12425418; rs11065707; rs2268398; rs12371563; rs7398948; rs12818998; rs2284698; rs11065789; rs124550; rs16934132; rs7979520; rs246093; rs7973602; rs10774612; rs11065802; rs34283; rs246097; rs11609393; rs246088; rs11610881; rs7968098; rs1654874; rs1642041; rs11831322; rs16940069; rs4766454; rs12427320; rs6606693; rs11615890; rs12298635; rs12302686; rs34272; rs34874322; rs10774628; rs11065821; rs1013746; rs34282; rs2284696; rs7976118; rs2300458; rs11836009; rs12582316; rs17848825; rs3742025; rs12826842; rs17848802; rs17848833; rs17848829; rs17848835; rs17848820; rs7970183; rs17848814; rs17848845; rs11065655; rs17848813; rs11548069; rs3832872; rs34748130; rs35990385; rs34512735; rs2284688; rs28488820; rs35774241; rs28547878; rs11612011; rs17848840; rs35231287; rs7315250; rs11065745; rs35195118; rs34972531; rs1109760; rs11615298; rs12298475; rs17848817; rs9788095; rs11065768; rs34484411; rs35696831; rs165969; rs12316576; rs3036244; rs4766498; rs35008047; rs17848821; rs11065799; rs35186286; rs10437833; rs35926930; rs35867442; rs11065801; rs10571468; rs7974907; rs12307691; rs11065736; rs35552400; rs36177511; rs10437834; rs10538426; rs7964396; rs11065928; rs12299461; rs28720807; rs12296234; rs10710817; rs34724260; rs12823966; rs35920161; rs12831074; rs2268395; rs36109526; rs7969465; rs34403757; rs34117730; rs11066012; rs35405212; rs35954050; rs34476328; rs35307494; rs12316357; rs9788220; rs11065658; rs35795929; rs35681511; rs11503164; rs34770418; rs11065940; rs11395613; rs35720403; rs7488422; rs12579892; rs17848815; rs34837288; rs12825055; rs12824057; rs35109388; rs8181692; rs3858708; rs7973342; rs7486876; rs35377986; rs12821387; rs34104231; rs35850916; rs35572712; rs7310593; rs2337853; rs12299192; rs2337854; rs35687063; rs35811875; rs17848844; rs34557433; rs36026617; rs9788203; rs34277; rs16940066; rs36041654; rs11065662; rs2300461; rs34920588; rs11066017; rs4766465; rs36074981; rs34249818; rs7955252; rs12371594; rs28651750; rs12823154; rs35305860; rs35073931; rs12099597; rs2268386; rs34696463; rs35831566; rs7484350; rs5800844; rs11316464; rs36041556; rs36066302; rs17848828; rs11615286; rs16940064; rs35119176; rs12579592; rs34587709; rs12820080; rs34392052; rs34483985; rs12367997; rs34243322; rs35315851; rs34161814; rs16934151; rs3214393; rs3057528; rs34265; rs34289600; rs34435040; rs11066014; rs7969552; rs28720113; rs12298532; rs17848826; rs10624857; rs11610925; rs35399427; rs11611648; rs34705590; rs12824632; rs34681726; rs7953267; rs11065948; rs34174568; rs34959945; rs36042486; rs34726323; rs4766463; rs34849464; rs4766581; rs12313567; rs7131928; rs10668263; rs3216576; rs35999044; rs35102243; rs35804667; rs17848843; rs11614298; rs34163065; rs4540880; rs12314997; rs10661545; rs35966344; rs34264; rs7358773; rs34479274; rs11065895; rs11065721; rs11446315; rs7301465; rs11065775; rs34863094; rs35824270; rs3831809; rs11065990; rs7310798; rs35578182; rs11611744; rs12314181; rs35482988; rs11065797; rs11066016; rs35432960; rs35844029; rs7952806; rs35325175; rs35536047; rs17848819; rs17848836; rs35518223; rs35212189; rs11310506; rs12820656; rs35573065; rs3759388; rs34267119; rs10625076; rs11065726; rs2300451; rs12579902; rs36059668; rs10710816; rs7969904; rs17848818; rs7135143; rs10849899; rs35810122; rs35843775; rs12302530; rs17848804; rs12302388; rs2284692; rs5800843; rs34400478; rs11065798; rs35751957; rs7976048; rs11065723; rs34736443; rs9668738; rs34112199; rs10696128; rs17848848; rs35375735; rs34154284; rs10616119; rs11503165; rs9668198; rs34673513; rs34280406; rs35920688; rs4766493; rs3759389; rs34617875; rs5800845; rs35532847; rs10492215; rs1104738; rs11065634; rs11066035; rs11066064; rs11831841; rs12316092; rs12316300; rs12317282; rs12320115; rs12321538; rs12580798; rs1642036; rs1642037; rs1642038; rs1654875; rs1654876; rs1654884; rs16939972; rs34290629; rs7305012; rs7309513; rs7969109; rs882355

# Metabolic_Enzyme_1_General_References:
9099716; 8670171

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5755

# Metabolic_Enzyme_2_Name:
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial precursor

# Metabolic_Enzyme_2_Synonyms:
3-methylcrotonyl-CoA carboxylase 2; MCCase subunit beta; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; 3- methylcrotonyl-CoA carboxylase non-biotin-containing subunit

# Metabolic_Enzyme_2_Gene_Name:
MCCC2

# Metabolic_Enzyme_2_Protein_Sequence:
>MethylcrotonoylCoA carboxylase beta chain, mitochondrial precursor
MWAVLRLALRPCARASPAGPRAYHGDSVASLGTQPDLGSALYQENYKQMKALVNQLHERV
EHIKLGGGEKARALHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYDNEEVPGGGII
TGIGRVSGVECMIIANDATVKGGAYYPVTVKKQLRAQEIAMQNRLPCIYLVDSGGAYLPR
QADVFPDRDHFGRTFYNQAIMSSKNIAQIAVVMGSCTAGGAYVPAMADENIIVRKQGTIF
LAGPPLVKAATGEEVSAEDLGGADLHCRKSGVSDHWALDDHHALHLTRKVVRNLNYQKKL
DVTIEPSEEPLFPADELYGIVGANLKRSFDVREVIARIVDGSRFTEFKAFYGDTLVTGFA
RIFGYPVGIVGNNGVLFSESAKKGTHFVQLCCQRNIPLLFLQNITGFMVGREYEAEGIAK
DGAKMVAAVACAQVPKITLIIGGSYGAGNYGMCGRAYSPRFLYIWPNARISVMGGEQAAN
VLATITKDQRAREGKQFSSADEAALKEPIIKKFEEEGNPYYSSARVWDDGIIDPADTRLV
LGLSFSAALNAPIEKTDFGIFRM

# Metabolic_Enzyme_2_Number_of_Residues:
563

# Metabolic_Enzyme_2_Molecular_Weight:
61334

# Metabolic_Enzyme_2_Theoretical_pI:
7.75

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  ligase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
ATP + 3-methylcrotonoyl-CoA + HCO(3)(-) = ADP + phosphate + 3-methylglutaconyl-CoA

# Metabolic_Enzyme_2_Pathway:
map00280  Valine, leucine and isoleucine degradation

# Metabolic_Enzyme_2_Reaction:
ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01039:Carboxyl_trans

# Metabolic_Enzyme_2_Signals:
1-15

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 6.4.1.4

# Metabolic_Enzyme_2_GenBank_ID_Protein:
10934059

# Metabolic_Enzyme_2_SwissProt_ID:
MCCC2_HUMAN (Q9HCC0)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
MCCC2

# Metabolic_Enzyme_2_Geneatlas_id:
MCCC2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:6937

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_2_Gene_Sequence:
>1692 bp
ATGTGGGCCGTCCTGAGGTTAGCCCTGCGGCCGTGTGCCCGCGCCTCTCCCGCCGGGCCG
CGCGCCTATCACGGGGACTCGGTGGCCTCGCTGGGCACCCAGCCGGACTTGGGCTCTGCC
CTCTACCAGGAGAACTACAAGCAGATGAAAGCACTAGTAAATCAGCTCCATGAACGAGTG
GAGCATATAAAACTAGGAGGTGGTGAGAAAGCCCGAGCACTTCACATATCAAGAGGAAAA
CTATTGCCCAGAGAAAGAATTGACAATCTCATAGACCCAGGGTCTCCATTTCTGGAATTA
TCCCAGTTTGCAGGTTACCAGTTATATGACAATGAGGAGGTGCCAGGAGGTGGCATTATT
ACAGGCATTGGAAGAGTATCAGGAGTAGAATGCATGATTATTGCCAATGATGCCACCGTC
AAAGGAGGTGCCTACTACCCAGTGACTGTGAAAAAACAATTACGGGCCCAAGAAATTGCC
ATGCAAAACAGGCTCCCCTGCATCTACTTAGTTGATTCGGGAGGAGCATACTTACCTCGA
CAAGCAGATGTGTTTCCAGATCGAGACCACTTTGGCCGTACATTCTATAATCAGGCAATT
ATGTCTTCTAAAAATATTGCACAGATCGCAGTGGTCATGGGCTCCTGCACCGCAGGAGGA
GCCTATGTGCCTGCCATGGCTGATGAAAACATCATTGTACGCAAGCAGGGTACCATTTTC
TTGGCAGGACCCCCCTTGGTTAAAGCGGCAACTGGGGAAGAAGTATCTGCTGAGGATCTT
GGAGGTGCTGATCTTCATTGCAGAAAGTCTGGAGTAAGTGACCACTGGGCTTTGGATGAT
CATCATGCCCTTCACTTAACTAGGAAGGTTGTGAGGAATCTAAATTATCAGAAGAAATTG
GATGTCACCATTGAACCTTCTGAAGAGCCTTTATTTCCTGCTGATGAATTGTATGGAATA
GTTGGTGCTAACCTTAAGAGGAGCTTTGATGTCCGAGAGGTCATTGCTAGAATCGTGGAT
GGAAGCAGATTCACTGAGTTCAAAGCCTTTTATGGAGACACATTAGTTACAGGATTTGCT
CGAATATTTGGGTACCCAGTAGGTATCGTTGGAAACAACGGAGTTCTCTTTTCTGAATCT
GCAAAAAAGGGTACTCACTTTGTCCAGTTATGCTGCCAAAGAAATATTCCTCTGCTGTTC
CTTCAAAACATTACTGGATTTATGGTTGGTAGAGAGTATGAAGCTGAAGGAATTGCCAAG
GATGGTGCCAAGATGGTGGCCGCTGTGGCCTGTGCCCAAGTGCCTAAGATAACCCTCATC
ATTGGGGGCTCCTATGGAGCCGGAAACTATGGGATGTGTGGCAGAGCGTATAGCCCAAGA
TTTCTCTACATTTGGCCAAATGCTCGTATCTCAGTGATGGGAGGAGAGCAGGCAGCCAAT
GTGTTGGCCACGATAACAAAGGACCAAAGAGCCCGGGAAGGAAAGCAGTTCTCCAGTGCT
GATGAAGCGGCTTTAAAAGAGCCCATCATTAAGAAGTTTGAAGAGGAAGGAAACCCTTAC
TATTCCAGCGCAAGGGTATGGGATGATGGGATCATTGATCCAGCAGACACCAGACTGGTC
TTGGGTCTCAGTTTTAGTGCAGCCCTCAACGCACCAATAGAGAAGACTGACTTCGGTATC
TTCAGGATGTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AB050049

# Metabolic_Enzyme_2_Chromosome_Location:
Not Available

# Metabolic_Enzyme_2_Locus:
Not Available

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
11406611; 11181649

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5756

# Metabolic_Enzyme_3_Name:
Biotin--protein ligase

# Metabolic_Enzyme_3_Synonyms:
Biotin apo-protein ligase[Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase; Holocarboxylase synthetase; HCS; Biotin-- [methylcrotonoyl-CoA-carboxylase] ligase

# Metabolic_Enzyme_3_Gene_Name:
HLCS

# Metabolic_Enzyme_3_Protein_Sequence:
>Biotinprotein ligase
MEDRLHMDNGLVPQKIVSVHLQDSTLKEVKDQVSNKQAQILEPKPEPSLEIKPEQDGMEH
VGRDDPKALGEEPKQRRGSASGSEPAGDSDRGGGPVEHYHLHLSSCHECLELENSTIESV
KFASAENIPDLPYDYSSSLESVADETSPEREGRRVNLTGKAPNILLYVGSDSQEALGRFH
EVRSVLADCVDIDSYILYHLLEDSALRDPWTDNCLLLVIATRESIPEDLYQKFMAYLSQG
GKVLGLSSSFTFGGFQVTSKGALHKTVQNLVFSKADQSEVKLSVLSSGCRYQEGPVRLSP
GRLQGHLENEDKDRMIVHVPFGTRGGEAVLCQVHLELPPSSNIVQTPEDFNLLKSSNFRR
YEVLREILTTLGLSCDMKQVPALTPLYLLSAAEEIRDPLMQWLGKHVDSEGEIKSGQLSL
RFVSSYVSEVEITPSCIPVVTNMEAFSSEHFNLEIYRQNLQTKQLGKVILFAEVTPTTMR
LLDGLMFQTPQEMGLIVIAARQTEGKGRGGNVWLSPVGCALSTLLISIPLRSQLGQRIPF
VQHLMSVAVVEAVRSIPEYQDINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYILIGC
GFNVTNSNPTICINDLITEYNKQHKAELKPLRADYLIARVVTVLEKLIKEFQDKGPNSVL
PLYYRYWVHSGQQVHLGSAEGPKVSIVGLDDSGFLQVHQEGGEVVTVHPDGNSFDMLRNL
ILPKRR

# Metabolic_Enzyme_3_Number_of_Residues:
726

# Metabolic_Enzyme_3_Molecular_Weight:
80761

# Metabolic_Enzyme_3_Theoretical_pI:
5.34

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  biotin-protein ligase activity
Function:  biotin-[acetyl-CoA-carboxylase] ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Posttranslational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase

# Metabolic_Enzyme_3_Pathway:
map00780  Biotin metabolism

# Metabolic_Enzyme_3_Reaction:
ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF02237:BPL_C;
PF03099:BPL_LipA_LipB

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 6.3.4.9;EC 6.3.4.10;EC

# Metabolic_Enzyme_3_GenBank_ID_Protein:
577625

# Metabolic_Enzyme_3_SwissProt_ID:
BPL1_HUMAN (P50747)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
HLCS

# Metabolic_Enzyme_3_Geneatlas_id:
HLCS

# Metabolic_Enzyme_3_hgnc_id:
HGNC:4976

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm. Mitochondrion

# Metabolic_Enzyme_3_Gene_Sequence:
>2181 bp
ATGGAAGATAGACTCCACATGGATAATGGACTGGTACCCCAAAAGATTGTGTCGGTGCAC
TTGCAGGACTCCACTCTGAAGGAAGTTAAGGATCAGGTCTCAAACAAGCAAGCCCAGATC
CTAGAGCCGAAGCCTGAACCTTCTCTTGAGATTAAGCCTGAGCAGGACGGTATGGAGCAT
GTTGGCAGAGATGACCCAAAGGCTCTTGGTGAAGAACCCAAACAAAGGAGAGGCAGTGCC
TCTGGGAGTGAGCCTGCTGGGGACAGTGACAGGGGAGGGGGCCCCGTTGAGCATTATCAC
CTCCATCTGTCTAGTTGCCACGAGTGTCTGGAACTTGAGAACAGCACCATTGAGTCAGTC
AAGTTTGCGTCTGCCGAGAACATTCCAGACCTTCCCTACGATTATAGCAGCAGTTTGGAG
AGTGTTGCTGATGAGACCTCCCCCGAAAGAGAAGGGAGGAGAGTCAACCTCACGGGAAAG
GCACCCAACATCCTCCTCTATGTGGGCTCCGACTCCCAGGAAGCCCTCGGCCGGTTCCAC
GAGGTCCGGTCTGTGCTGGCCGACTGTGTGGACATTGACAGTTATATTCTCTACCACCTG
CTGGAGGACAGTGCTCTCAGAGACCCGTGGACGGACAACTGTCTGCTGTTGGTCATTGCT
ACCAGGGAGTCCATTCCCGAAGACCTGTACCAGAAGTTCATGGCCTATCTTTCTCAGGGA
GGGAAGGTGTTGGGCCTGTCTTCATCCTTCACCTTTGGTGGCTTTCAGGTGACAAGCAAG
GGTGCACTGCACAAGACAGTCCAGAACTTGGTTTTCTCCAAGGCTGACCAGAGCGAGGTG
AAGCTCAGCGTCTTGAGCAGTGGCTGCAGGTACCAGGAAGGCCCCGTCCGGCTCAGCCCC
GGCAGGCTCCAGGGCCACCTGGAGAATGAGGACAAGGACAGGATGATTGTGCATGTGCCT
TTTGGAACTCGCGGGGGAGAAGCTGTTCTTTGCCAGGTGCACTTAGAACTACCTCCCAGC
TCCAACATAGTGCAAACTCCAGAAGATTTTAACTTGCTCAAGTCAAGCAATTTTAGAAGA
TACGAAGTCCTTAGAGAGATTCTGACAACCCTTGGCCTCAGCTGTGACATGAAACAAGTT
CCTGCCTTAACTCCTCTTTACTTGCTGTCAGCTGCGGAGGAAATCAGGGATCCTCTTATG
CAGTGGCTTGGGAAACATGTGGACTCCGAGGGAGAAATAAAATCCGGCCAGCTCTCTCTT
AGATTTGTTTCATCCTACGTGTCTGAAGTAGAAATAACCCCATCTTGTATACCTGTGGTG
ACCAACATGGAGGCCTTCTCATCAGAACATTTCAACTTAGAGATCTATCGCCAAAATCTG
CAGACCAAGCAGTTGGGGAAAGTAATTTTGTTTGCCGAAGTGACCCCCACAACGATGCGT
CTCCTGGATGGGCTGATGTTTCAGACACCGCAGGAAATGGGCTTAATAGTGATCGCGGCC
CGGCAGACCGAGGGCAAAGGACGGGGAGGGAATGTGTGGCTGAGCCCTGTGGGATGTGCT
CTTTCTACTCTGCTCATCTCCATTCCACTGAGATCCCAGCTGGGACAGAGGATCCCGTTT
GTCCAGCATCTGATGTCCGTGGCTGTCGTGGAAGCAGTGAGGTCCATTCCCGAGTATCAG
GATATCAACTTACGAGTGAAGTGGCCCAACGATATTTATTACAGTGACCTCATGAAGATC
GGCGGAGTTCTGGTTAACTCAACACTCATGGGAGAAACATTTTATATACTTATTGGCTGT
GGATTTAATGTGACTAACAGTAACCCTACCATCTGCATCAACGACCTCATCACAGAATAC
AATAAACAACACAAGGCAGAACTGAAGCCCTTAAGAGCCGATTATCTCATCGCCAGAGTC
GTGACTGTGCTGGAGAAACTGATCAAAGAGTTTCAGGACAAAGGGCCCAACAGCGTCCTT
CCCCTTTATTACCGATACTGGGTCCACAGTGGTCAGCAAGTCCATCTGGGCAGCGCAGAG
GGACCAAAGGTGTCCATCGTTGGCCTGGACGATTCTGGCTTCCTCCAGGTTCACCAGGAG
GGCGGCGAGGTTGTGACTGTGCACCCGGACGGCAACTCCTTCGACATGCTGAGAAACCTC
ATCCTCCCCAAACGGCGGTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
D23672

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
rs1065759; rs1065758; rs2230182; rs2835547; rs2835543; rs2835554; rs2835544; rs1892916; rs2835553; rs2835545; rs2016215; rs2835557; rs2835546; rs2835552; rs9636908; rs2835548; rs2835555; rs1893653; rs2835550; rs2843637; rs3827189; rs2835549; rs2835541; rs4817839; rs12626528; rs8126588; rs8127595; rs2835551; rs11910240; rs12627541; rs6517397; rs369888; rs2835556; rs10084553; rs2845814; rs4816551; rs2409871; rs12483284; rs1571702; rs4817840; rs762373; rs445437; rs997627; rs2032087; rs12483456; rs762376; rs1893654; rs7277523; rs1893655; rs1571700; rs9978381; rs727961; rs6517396; rs3827190; rs3179477; rs6517395; rs4816557; rs7281321; rs14407; rs7276605; rs7283846; rs2409870; rs7277447; rs3819154; rs7282108; rs7280331; rs13052315; rs8127236; rs2835542; rs762374; rs12626531; rs1050706; rs7281251; rs2154530; rs13048613; rs13049125; rs11700650; rs9636909; rs8129634; rs11909178; rs11702480; rs9981774; rs9983516; rs1007423; rs11701986; rs8131277; rs7509886; rs7276406; rs4817832; rs2154533; rs762375; rs12482985; rs4817835; rs11909152; rs2154532; rs8126740; rs4816553; rs2843627; rs7276518; rs1012962; rs7280892; rs1986063; rs9981407; rs16997934; rs7509870; rs1055700; rs2016219; rs8130063; rs3191054; rs7276371; rs9967991; rs412162; rs2154529; rs7282422; rs1050707; rs4817838; rs12626619; rs1055699; rs2032086; rs1007421; rs10084551; rs4817834; rs12626945; rs2843633; rs9974970; rs9976131; rs2835520; rs2835489; rs2835535; rs2835505; rs2835472; rs2835531; rs2835463; rs2073425; rs2835516; rs765321; rs1984020; rs2835537; rs2835511; rs2835506; rs745147; rs2835532; rs2835480; rs2256034; rs2245447; rs2835515; rs2835483; rs2835455; rs2835454; rs2245524; rs2835474; rs2835510; rs2835487; rs1041437; rs2835538; rs2000550; rs2835539; rs2835534; rs2835486; rs2835465; rs2835485; rs2835519; rs2835513; rs2245349; rs2835525; rs2073424; rs3827185; rs3787749; rs2835508; rs2835467; rs7280984; rs2835491; rs2073420; rs2236435; rs2835499; rs762369; rs1892913; rs2156419; rs8134067; rs999373; rs1010385; rs3787755; rs2835500; rs2835458; rs8129544; rs3787759; rs7280602; rs2835527; rs6517385; rs2000549; rs2835484; rs2835471; rs8127309; rs999372; rs2835461; rs6517394; rs3787741; rs2835478; rs2835488; rs2835498; rs6517390; rs2835468; rs8130819; rs2835481; rs2835495; rs2835477; rs2245353; rs3787756; rs8134742; rs11088366; rs12627703; rs2835497; rs2835482; rs2835517; rs2835529; rs2835493; rs2835533; rs2835464; rs1015017; rs9978519; rs743429; rs2835503; rs2835509; rs8134293; rs2835514; rs2835473; rs8133376; rs8129637; rs762370; rs2835502; rs3787771; rs1467857; rs2835476; rs9981318; rs2835466; rs3787751; rs2835526; rs3787764; rs6517386; rs2835528; rs766212; rs928845; rs2835504; rs8131323; rs8133029; rs9977855; rs2835459; rs2187305; rs2835479; rs2156420; rs7282868; rs2835530; rs12627271; rs2835501; rs6517384; rs11702761; rs1009778; rs2845810; rs3787739; rs2845805; rs8131621; rs3787752; rs9941899; rs7278038; rs9981513; rs4402840; rs2835524; rs2845811; rs1023409; rs12627285; rs11910692; rs8134448; rs2850120; rs2835507; rs2835496; rs6517392; rs8130179; rs2073421; rs6517389; rs11701858; rs3787748; rs11088368; rs16994604; rs12627666; rs9981651; rs2835475; rs2073419; rs2835494; rs2016223; rs12151959; rs2845804; rs2835518; rs2845812; rs6517391; rs9977488; rs7279278; rs2835470; rs8132538; rs7275269; rs2276230; rs9680246; rs10483036; rs2835523; rs2835490; rs10154119; rs6517388; rs13047304; rs1029248; rs8131480; rs11088367; rs7276758; rs2070523; rs3827187; rs8134687; rs12481910; rs2835453; rs743430; rs2409842; rs2073422; rs16994521; rs7276082; rs2835457; rs7276265; rs12627662; rs762367; rs9977769; rs3787757; rs2835536; rs13050480; rs2835469; rs2409865; rs2850104; rs2850106; rs11910768; rs7275322; rs725719; rs2105752; rs11702134; rs2236434; rs8134083; rs2845817; rs1029247; rs2835492; rs2835521; rs13052249; rs6517387; rs2073423; rs4817822; rs9636905; rs9647169; rs8127553; rs13047322; rs3787754; rs732252; rs1041832; rs8130235; rs8132874; rs16994508; rs3827188; rs2835462; rs7276185; rs2898312; rs7278981; rs8133818; rs999374; rs11911767; rs16994519; rs11701035; rs3787750; rs2073418; rs2850118; rs3787765; rs7277563; rs2835460; rs17228878; rs11701632; rs13050751; rs8131510; rs8129230; rs8132327; rs7278075; rs6517381; rs2245325; rs3842450; rs4817828; rs7283004; rs16997932; rs12627476; rs7281419; rs16994573; rs11700783; rs2065303; rs17192962; rs11700880; rs8129291; rs8131843; rs11088365; rs4501027; rs8132225; rs3838087; rs7278053; rs12627335; rs933159; rs762368; rs3787767; rs7280590; rs12481800; rs8130004; rs3787753; rs12483475; rs17814272; rs10451759; rs8129887; rs2282501; rs9647072; rs7510213; rs8132547; rs12482724; rs3787768; rs4817823; rs1968034; rs16994591; rs12626955; rs9977713; rs8126803; rs7279810; rs12626368; rs16994424; rs2845819; rs11702434; rs8129140; rs8132325; rs960498; rs11702727; rs8130658; rs1968035; rs12627519; rs3787740; rs17814278; rs13052574; rs9978312; rs4817821; rs8134086; rs11909707; rs8131697; rs16994586; rs4146071; rs3787760; rs7509790; rs7280746; rs11909766; rs2835522; rs2850119; rs2845813; rs7279818; rs16994438; rs2409867; rs11911648; rs7283401; rs17228899; rs1892912; rs17284196; rs16994530; rs2835456; rs9305605; rs11701958; rs11910919; rs7283417; rs16994503; rs2835512; rs7283871; rs16994435; rs8130485; rs8130689; rs9985116; rs10154239; rs7280597; rs2850105; rs16994594; rs2850103; rs7280357; rs7283538; rs13045992; rs11088364; rs2898305; rs2032320; rs2096494; rs28934602; rs10586592; rs7280923; rs11393391; rs4817837; rs3035109; rs10555694; rs6147500; rs28593435; rs2010867; rs13050516; rs4816555; rs35275580; rs11911628; rs3035147; rs13047776; rs10439668; rs2250250; rs9976746; rs35410170; rs34322027; rs11088370; rs9978378; rs34080483; rs4817833; rs5843777; rs34917953; rs12481939; rs35414914; rs7283304; rs8130102; rs35626237; rs4817836; rs34507014; rs3035114; rs11911653; rs35627163; rs35955622; rs35662085; rs35497414; rs2154531; rs12627081; rs9975027; rs13046475; rs9980304; rs7281145; rs10714466; rs35614243; rs9979522; rs11327894; rs35458660; rs34562090; rs28690635; rs33973072; rs28429232; rs34401947; rs11446217; rs11386640; rs8131045; rs35291269; rs28650072; rs1571701; rs4816552; rs34710014; rs12627106; rs2848944; rs28694191; rs28530; rs11326506; rs3031056; rs34107101; rs10572120; rs35365431; rs10658878; rs28873986; rs35392286; rs35583976; rs2845823; rs35174119; rs34036236; rs35269254; rs11345329; rs7276359; rs7280124; rs2848945; rs7276076; rs13050356; rs5843783; rs13049535; rs35601107; rs34807872; rs2845822; rs1540010; rs2843959; rs34377311; rs12626655; rs35868871; rs35980239; rs35710980; rs4816554; rs35634082; rs13049080; rs34220466; rs35662012; rs35520036; rs34080155; rs13046468; rs13050438; rs3035105; rs7280358; rs13050355; rs35779811; rs36112603; rs28610288; rs13050617; rs8128381; rs12481773; rs3787776; rs35700333; rs3035112; rs33951816; rs13051338; rs9984942; rs13052725; rs34357006; rs8133111; rs36042341; rs9983255; rs35509622; rs2850116; rs35869521; rs11294369; rs35182597; rs4437044; rs11297044; rs12483583; rs9305606; rs9680205; rs35822038; rs5843781; rs11702621; rs13053024; rs35796252; rs35095559; rs34254252; rs2845809; rs34407031; rs34091454; rs12152092; rs11701245; rs34788426; rs11390960; rs1892914; rs2409866; rs10533053; rs13050215; rs34132309; rs1080320; rs11367391; rs34296856; rs4817819; rs34750859; rs7510407; rs10222039; rs10222041; rs34494258; rs36115487; rs10527838; rs7281668; rs10675191; rs12482385; rs36094571; rs34518438; rs11700970; rs7280703; rs35996984; rs34580139; rs11701954; rs4816549; rs36030626; rs35066001; rs7278768; rs35736294; rs28433522; rs34042688; rs10667373; rs34834985; rs35033735; rs28420273; rs34614171; rs4817826; rs13048483; rs10578979; rs34474993; rs9978513; rs35086153; rs7281557; rs35055957; rs28717023; rs34606135; rs34108918; rs34352427; rs9305607; rs4817820; rs10673271; rs34525201; rs11464249; rs10671954; rs34011883; rs34569598; rs13048364; rs35780817; rs3787762; rs1807005; rs7277291; rs35188541; rs2850117; rs35393537; rs34364909; rs11297456; rs34450454; rs6517380; rs34753772; rs2845818; rs34057978; rs8128030; rs34115036; rs7276860; rs35778622; rs2845808; rs11384058; rs12626778; rs10701851; rs35753864; rs13049458; rs9980828; rs8127419; rs35751606; rs11909879; rs11297170; rs35402890; rs34791770; rs35945376; rs34814328; rs28478303; rs2850107; rs34260234; rs10660857; rs12482621; rs34247489; rs34777766; rs11306825; rs36038593; rs34292112; rs34938617; rs11418922; rs34340177; rs8133296; rs11317768; rs7278191; rs2898307; rs9975316; rs11701120; rs34199456; rs36086662; rs11291576; rs35352430; rs35493457; rs8130859; rs34541224; rs2845815; rs9979967; rs35818278; rs8134476; rs35808041; rs33933191; rs34276663; rs17461392; rs13047682; rs7283722; rs28837399; rs2845807; rs2845816; rs13047748; rs12627632; rs34836716; rs7281692; rs34141324; rs8134223; rs35389223; rs8127533; rs35468614; rs8128099; rs35329905; rs11908840; rs12627303; rs10460714; rs7278010; rs34602439; rs34203769; rs2409864; rs1023151; rs28393024; rs34954888; rs34016490; rs35012674; rs8134332; rs35663376; rs35419478; rs13047923; rs35436718; rs4146072; rs34087473; rs36053269; rs34963503; rs9305608; rs9636906; rs34820991; rs35737292; rs35524379; rs7277631; rs3787747; rs34722227; rs11464248; rs34473124; rs34498809; rs5843779; rs4817824; rs11344082; rs10683958; rs766213; rs36004832; rs35877361; rs36071670; rs10601692; rs8127710; rs35854823; rs34695780; rs2898306; rs34861975; rs11445706; rs3787763; rs35372493; rs35181716; rs4817829; rs35148498; rs13052306; rs34623773; rs9982979; rs34491680; rs8128357; rs765322; rs12627215; rs35114323; rs34254349; rs7279029; rs5843780; rs4817825; rs6517382; rs8134282; rs3838088; rs35086549; rs35178355; rs36094620; rs2845806; rs34601566; rs16994535; rs34372660; rs2409841; rs7276595; rs34045793; rs35693831; rs9636907; rs33997626; rs35529573; rs13049750; rs9631176; rs35395049; rs35754533; rs34877069; rs35184977; rs28625302; rs11701876; rs34016299; rs3840081; rs2409868; rs11287408; rs35744528; rs11908847; rs35420087; rs11290275; rs11323079; rs35056286; rs10699749; rs35246209; rs11464250; rs7280002; rs5843778; rs35247519; rs11353178; rs36000333; rs11088363; rs34153712; rs34389255; rs16994517; rs35042573; rs36027016; rs35323345; rs11701088; rs11464247; rs34592171; rs35050680; rs34390839; rs10696901; rs8127560; rs34392668; rs9680178; rs34427088; rs9984754; rs36040380; rs34908465; rs7282396; rs34792541; rs3132398; rs2843630; rs3094305; rs2843629; rs35788112; rs1005404; rs12627480; rs13050453; rs13052602; rs16994660; rs1892915; rs1893656; rs1970053; rs2002799; rs2051397; rs2070519; rs2070520; rs2073416; rs2073417; rs2073601; rs2073602; rs2073603; rs2186335; rs2187102; rs2409872; rs2835451; rs2835540; rs2843961; rs7281817; rs8131293; rs8132470; rs877686; rs9982519

# Metabolic_Enzyme_3_General_References:
7842009; 11735028; 10830953; 9503011; 8541348; 8817339; 9396568; 10190325

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5757

# Metabolic_Enzyme_4_Name:
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
3-methylcrotonyl-CoA carboxylase 1; MCCase subunit alpha; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; 3- methylcrotonyl-CoA carboxylase biotin-containing subunit

# Metabolic_Enzyme_4_Gene_Name:
MCCC1

# Metabolic_Enzyme_4_Protein_Sequence:
>MethylcrotonoylCoA carboxylase subunit alpha, mitochondrial precursor
MAAASAVSVLLVAAERNRWHRLPSLLLPPRTWVWRQRTMKYTTATGRNITKVLIANRGEI
ACRVMRTAKK
LGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKT
SAAQAIHPGCGFLSENMEFAE
LCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVV
EGYHGEDQSDQCLKEHARRIGYPVMIKAVRGG
GGKGMRIVRSEQEFQEQLESARREAKK
SFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQR
RHQKIIEEAPAPGIKS
EVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMI
TGTDL
VEWQLRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTR
IETGV
RQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLS
GHPEFEAGNVHTDFIP
QHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQ
FSPFSSSSGRRLNISYTRNMTLKDGKN
NVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSE
GDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEID
IPVPKYLSSVSSQETQGGPLA
PMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYR
EGAQANRHTP
LVEFEEEESDKRESE

# Metabolic_Enzyme_4_Number_of_Residues:
725

# Metabolic_Enzyme_4_Molecular_Weight:
80474

# Metabolic_Enzyme_4_Theoretical_pI:
7.86

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  ligase activity
Function:  vitamin binding
Function:  biotin binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
ATP + 3-methylcrotonoyl-CoA + HCO(3)(-) = ADP + phosphate + 3-methylglutaconyl-CoA

# Metabolic_Enzyme_4_Pathway:
map00280  Valine, leucine and isoleucine degradation

# Metabolic_Enzyme_4_Reaction:
ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF02785:Biotin_carb_C;
PF00364:Biotin_lipoyl;
PF00289:CPSase_L_chain;
PF02786:CPSase_L_D2

# Metabolic_Enzyme_4_Signals:
1-14

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 6.4.1.4

# Metabolic_Enzyme_4_GenBank_ID_Protein:
12382296

# Metabolic_Enzyme_4_SwissProt_ID:
MCCA_HUMAN (Q96RQ3)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
MCCC1

# Metabolic_Enzyme_4_Geneatlas_id:
MCCC1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:6936

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_4_Gene_Sequence:
>2178 bp

ATGGCGGCGGCCTCTGCGGTGTCGGTGCTGCTGGTGGCGGCGGAGAGGAACCGGTGGCA
TCGTCTCCCGA
GCCTGCTCCTGCCGCCGAGGACATGGGTGTGGAGGCAAAGAACCATGA
AGTACACAACAGCCACAGGAAG
AAACATTACCAAGGTCCTCATTGCAAACAGAGGAGAA
ATTGCCTGCAGGGTGATGCGCACAGCCAAAAAA
CTGGGTGTACAGACTGTGGCGGTTTA
TAGTGAGGCTGACAGAAATTCCATGCATGTAGATATGGCAGATG
AAGCATATTCCATCG
GCCCCGCTCCCTCCCAGCAGAGCTACCTATCTATGGAGAAAATCATTCAAGTGGC
CAAG
ACCTCTGCTGCACAGGCTATCCATCCAGGATGCGGTTTTCTTTCAGAAAACATGGAATTT
GCTGAA
CTTTGTAAGCAAGAAGGAATTATTTTTATAGGCCCTCCTCCATCTGCAATTAG
AGACATGGGTATAAAGA
GCACATCCAAATCCATAATGGCTGCTGCTGGAGTACCTGTTG
TGGAGGGTTATCATGGTGAGGACCAATC
AGACCAGTGCCTGAAGGAACACGCCAGGAGA
ATTGGCTATCCTGTCATGATTAAAGCCGTCCGGGGTGGA
GGAGGAAAAGGAATGAGGAT
TGTTAGATCAGAACAAGAATTTCAAGAACAGTTAGAGTCAGCACGGAGAG
AAGCTAAGA
AGTCTTTCAATGATGATGCTATGCTGATCGAGAAGTTTGTAGACACACCGAGGCATGTAG
A
AGTCCAGGTGTTTGGTGATCACCATGGCAATGCTGTGTACTTGTTTGAAAGAGACTGT
AGTGTGCAGAGG
CGACATCAGAAGATCATTGAGGAGGCCCCAGCGCCTGGTATTAAATC
TGAAGTAAGAAAAAAGCTGGGAG
AAGCTGCAGTCAGAGCTGCTAAAGCTGTAAATTATG
TTGGAGCAGGGACTGTGGAGTTTATTATGGACTC
AAAACATAATTTCTGTTTCATGGAG
ATGAATACAAGGCTGCAAGTGGAACATCCTGTTACTGAGATGATC
ACAGGAACTGACTT
GGTGGAGTGGCAGCTTAGAATTGCAGCAGGAGAGAAGATTCCTTTGAGCCAGGAAG
AAA
TAACTCTGCAGGGCCATGCCTTCGAAGCTAGAATATATGCAGAAGATCCTAGCAATAACT
TCATGCC
TGTGGCAGGCCCATTAGTGCACCTCTCTACTCCTCGAGCAGACCCTTCCACC
AGGATTGAAACTGGAGTA
CGGCAAGGAGACGAAGTTTCCGTGCATTATGACCCCATGAT
TGCGAAGCTGGTCGTGTGGGCAGCAGATC
GCCAGGCGGCATTGACAAAACTGAGGTACA
GCCTTCGTCAGTACAATATTGTTGGACTGCACACCAACAT
TGACTTCTTACTCAACCTG
TCTGGCCACCCAGAGTTTGAAGCTGGGAACGTGCACACTGATTTCATCCCT
CAACACCA
CAAACAGTTGTTGCTCAGTCGGAAGGCTGCAGCCAAAGAGTCTTTATGCCAGGCAGCCCT
GG
GTCTCATCCTCAAGGAGAAAGCCATGACCGACACTTTCACTCTTCAGGCACATGATC
AATTCTCTCCATT
TTCGTCTAGCAGTGGAAGAAGACTGAATATCTCGTATACCAGAAAC
ATGACTCTTAAAGATGGTAAAAAC
AATGTAGCCATAGCTGTAACGTATAACCATGATGG
GTCTTATAGCATGCAGATTGAAGATAAAACTTTCC
AAGTCCTTGGTAATCTTTACAGCG
AGGGAGACTGCACTTACCTGAAATGTTCTGTTAATGGAGTTGCTAG
TAAAGCGAAGCTG
ATTATCCTGGAAAACACTATTTACCTATTTTCCAAGGAAGGAAGTATTGAGATTGAC
AT
TCCAGTCCCCAAATACTTATCTTCTGTGAGCTCACAAGAAACTCAGGGCGGCCCCTTAGC
TCCTATGA
CTGGAACCATTGAAAAGGTGTTTGTCAAAGCTGGAGACAAAGTGAAAGCGG
GAGATTCCCTCATGGTTAT
GATCGCCATGAAGATGGAGCATACCATAAAGTCTCCAAAG
GATGGCACAGTAAAGAAAGTGTTCTACAGA
GAAGGTGCTCAGGCCAACAGACACACTCC
TTTAGTCGAGTTTGAGGAGGAAGAATCAGACAAAAGGGAAT
CGGAATAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF310972

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_4_Locus:
3q27

# Metabolic_Enzyme_4_SNPs:
rs35219417; rs2270968; rs7622479; rs937652; rs2270967; rs1540735; rs1995426; rs6443848; rs10212195; rs10937108; rs6443849; rs6771735; rs6801608; rs9882050; rs6785680; rs11928508; rs6806390; rs7611168; rs2270969; rs6443846; rs1995427; rs6443842; rs7640612; rs12491196; rs1502762; rs4859271; rs10937112; rs12486983; rs4859156; rs1604586; rs1566705; rs12497989; rs11712267; rs9861225; rs7632904; rs10513789; rs4859274; rs2134427; rs6782692; rs1540736; rs10937106; rs13326553; rs10937111; rs1056565; rs4859154; rs6786878; rs10804888; rs7432920; rs2292057; rs11917464; rs11917378; rs12638619; rs12637471; rs6806083; rs9822789; rs2292056; rs9877289; rs10937105; rs9812846; rs13078931; rs6443850; rs9838514; rs9823766; rs6772568; rs3732604; rs12495806; rs4859266; rs13322798; rs10513790; rs13322863; rs3772721; rs6443845; rs4859265; rs13097765; rs4859153; rs11927776; rs2292058; rs1948799; rs7624867; rs6801522; rs13088830; rs6443844; rs7614207; rs7613986; rs9879377; rs7637448; rs9834143; rs4859273; rs7629763; rs2314738; rs4859268; rs12496512; rs13072934; rs1910279; rs11716229; rs10937107; rs4859151; rs3772722; rs9821577; rs7649701; rs2872702; rs11926525; rs13075596; rs12636930; rs4859267; rs1970864; rs9861464; rs6806354; rs6780763; rs2314737; rs13075011; rs9877655; rs12634147; rs12495766; rs12498020; rs11708689; rs1910280; rs4859276; rs13061424; rs1970863; rs7433755; rs13066020; rs7629760; rs11927250; rs11711666; rs16833689; rs9810968; rs4859264; rs7622140; rs7615536; rs4859275; rs7646991; rs6443843; rs9290752; rs7623700; rs7652556; rs1135365; rs6443840; rs1547910; rs7615451; rs4859262; rs9290751; rs9290750; rs4859150; rs7618801; rs6443851; rs35706839; rs36206712; rs34749281; rs11540930; rs41265429; rs35110907; rs34449442; rs34467860; rs35938218; rs35900486; rs35742027; rs6789698; rs11324054; rs28589465; rs11423070; rs3056488; rs34297292; rs12632373; rs11373462; rs34715234; rs4859263; rs7651093; rs6443847; rs28413605; rs10663232; rs35283773; rs34895943; rs4859269; rs11313652; rs17541829; rs35587538; rs10571331; rs13059375; rs10637737; rs28366717; rs35071527; rs12330492; rs35177725; rs11411314; rs28575398; rs34472753; rs34126309; rs34937697; rs34971116; rs34161676; rs7622965; rs28427471; rs6805277; rs10937110; rs10704597; rs4859270; rs34793741; rs34873451; rs35348780; rs28793315; rs16833679; rs11329735; rs36099251; rs34822404; rs10937109; rs11426247; rs36062669; rs4859272; rs34723716; rs4859155; rs41265427; rs11463635; rs35914626; rs16833681; rs4380436; rs35493081; rs28708863; rs34409416; rs35702045; rs10692178; rs34601027; rs34254014; rs34132711; rs7616810; rs35356364; rs34962125; rs13326155; rs35554340; rs34484607; rs35294219; rs6806155; rs10709578; rs11433120; rs36037059; rs5015387; rs34422438; rs4859152; rs9876859; rs35192508; rs34319336; rs6769550; rs6766367; rs6785198; rs34764997; rs10580342; rs35330892; rs34882766; rs6806512; rs34130252; rs34643375; rs10669856; rs33937574; rs6777617; rs36107560; rs34943658; rs28364748; rs35853083; rs35081437; rs11710342; rs11714270; rs11921003; rs12496089; rs4074110; rs4074310; rs4241561; rs6762373; rs6762726; rs6764058; rs6773022; rs6791884; rs7618830; rs7621434; rs7635560; rs9841498; rs9858038; rs9877549

# Metabolic_Enzyme_4_General_References:
11401427; 11406611; 11181649

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5490

# Metabolic_Enzyme_5_Name:
Propionyl-CoA carboxylase beta chain, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
PCCase subunit beta; Propanoyl-CoA:carbon dioxide ligase subunit beta

# Metabolic_Enzyme_5_Gene_Name:
PCCB

# Metabolic_Enzyme_5_Protein_Sequence:
>PropionylCoA carboxylase beta chain, mitochondrial precursor
MAAALRVAAVGARLSVLASGLRAAVRSLCSQATSVNERIENKRRTALLGGGQRRIDAQHK
RGKLTARERI
SLLLDPGSFVESDMFVEHRCADFGMAADKNKFPGDSVVTGRGRINGRLV
YVFSQDFTVFGGSLSGAHAQK
ICKIMDQAITVGAPVIGLNDSGGARIQEGVESLAGYAD
IFLRNVTASGVIPQISLIMGPCAGGAVYSPAL
TDFTFMVKDTSYLFITGPDVVKSVTNE
DVTQEELGGAKTHTTMSGVAHRAFENDVDALCNLRDFFNYLPL
SSQDPAPVRECHDPSD
RLVPELDTIVPLESTKAYNMVDIIHSVVDEREFFEIMPNYAKNIIVGFARMNGR
TVGIV
GNQPKVASGCLDINSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKL
LYAFA
EATVPKVTVITRKAYGGAYDVMSSKHLCGDTNYAWPTAEIAVMGAKGAVEIIFK
GHENVEAAQAEYIEKF
ANPFPAAVRGFVDDIIQPSSTRARICCDLDVLASKKVQRPWRK
HANIPL

# Metabolic_Enzyme_5_Number_of_Residues:
539

# Metabolic_Enzyme_5_Molecular_Weight:
58216

# Metabolic_Enzyme_5_Theoretical_pI:
7.69

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  ligase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
ATP + propanoyl-CoA + HCO(3)(-) = ADP + phosphate + (S)-methylmalonyl-CoA

# Metabolic_Enzyme_5_Pathway:
map00280  Valine, leucine and isoleucine degradation;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_5_Reaction:
ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01039:Carboxyl_trans

# Metabolic_Enzyme_5_Signals:
1-23

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 6.4.1.3

# Metabolic_Enzyme_5_GenBank_ID_Protein:
312812

# Metabolic_Enzyme_5_SwissProt_ID:
PCCB_HUMAN (P05166)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
PCCB

# Metabolic_Enzyme_5_Geneatlas_id:
PCCB

# Metabolic_Enzyme_5_hgnc_id:
HGNC:8654

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_5_Gene_Sequence:
>1620 bp

ATGGCGGCGGCATTACGGGTGGCGGCGGTCGGGGCAAGGCTCAGCGTTCTGGCGAGCGG
TCTCCGCGCCG
CGGTCCGCAGCCTTTGCAGCCAGGCCACCTCTGTTAACGAACGCATCG
AAAACAAGCGCCGGACCGCGCT
GCTGGGAGGGGGCCAACGCCGTATTGACGCGCAGCAC
AAGCGAGGAAAGCTAACAGCCAGGGAGAGGATC
AGTCTCTTGCTGGACCCTGGCAGCTT
TGTTGAGAGCGACATGTTTGTGGAACACAGATGTGCAGATTTTG
GAATGGCTGCTGACA
AGAATAAGTTTCCTGGAGACAGCGTGGTCACTGGACGAGGCCGAATCAATGGAAG
ATTG
GTTTATGTCTTCAGTCAGGATTTTACAGTTTTTGGAGGCAGTCTGTCAGGAGCACATGCC
CAAAAG
ATCTGCAAAATCATGGACCAGGCCATAACGGTGGGGGCTCCAGTGATTGGGCT
GAATGACTCTGGGGGAG
CACGGATCCAAGAAGGAGTGGAGTCTTTGGCTGGCTATGCAG
ACATCTTTCTGAGGAATGTTACGGCATC
CGGAGTCATCCCTCAGATTTCTCTGATCATG
GGCCCATGTGCTGGTGGGGCCGTCTACTCCCCAGCCCTA
ACAGACTTCACGTTCATGGT
AAAGGACACCTCCTACCTGTTCATCACTGGCCCTGATGTTGTGAAGTCTG
TCACCAATG
AGGATGTTACCCAGGAGGAGCTCGGTGGTGCCAAGACCCACACCACCATGTCAGGTGTGG
C
CCACAGAGCTTTTGAAAATGATGTTGATGCCTTGTGTAATCTCCGGGATTTCTTCAAC
TACCTGCCCCTG
AGCAGTCAGGACCCGGCTTCCGTCCGTGAGTGCCACGATCCCAGTGA
CCGTCTGGTTCCTGAGCTTGACA
CAATTGTCCCTTTGGAATCAACCAAAGCCTACAACA
TGGTGGACATCATACACTCTGTTGTTGATGAGCG
TGAATTTTTTGAGATCATGCCCAAT
TATGCCAAGAACATCATTGTTGGTTTTGCAAGAATGAATGGGAGG
ACTGTTGGAATTGT
TGGCAACCAACCTAAGGTGGCCTCAGGATGCTTGGATATTAATTCATCTGTGAAAG
GGG
CTCGTTTTGTCAGATTCTGTGATGCATTCAATATTCCACTCATCACTTTTGTTGATGTCC
CTGGCTT
TCTACCTGGCACAGCACAGGAATACGGGGGCATCATCCGGCATGGTGCCAAG
CTTCTCTACGCATTTGCT
GAGGCAACTGTACCCAAAGTCACAGTCATCACCAGGAAGGC
CTATGGAGGTGCCTATGATGTCATGAGCT
CTAAGCACCTTTGTGGTGATACCAACTATG
CCTGGCCCACCGCAGAGATTGCAGTCATGGGAGCAAAGGG
CGCTGTGGAGATCATCTTC
AAAGGGCATGAGAATGTGGAAGCTGCTCAGGCAGAGTACATCGAGAAGTTT
GCCAACCC
TTTCCCTGCAGCAGTGCGAGGGTTTGTGGATGACATCATCCAACCTTCTTCCACACGTGC
CC
GAATCTGCTGTGACCTGGATGTCTTGGCCAGCAAGAAGGTACAACGTCCTTGGAGAA
AACATGCAAATAT
TCCATTGTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X73424

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_5_Locus:
3q21-q22

# Metabolic_Enzyme_5_SNPs:
rs1711171; rs1153877; rs9844666; rs6776841; rs7622833; rs548288; rs1279425; rs2290131; rs1279086; rs553018; rs632016; rs650326; rs696081; rs4678428; rs664088; rs576771; rs650505; rs1279840; rs7650071; rs1279424; rs9872326; rs665200; rs9843348; rs6774573; rs7626889; rs17252498; rs6796523; rs12695645; rs4484145; rs684195; rs12492830; rs838202; rs681783; rs1618069; rs589092; rs9843801; rs483465; rs12488721; rs9853387; rs9826146; rs3821445; rs9833162; rs7653249; rs9289507; rs9289506; rs9835482; rs7633476; rs1279950; rs7622929; rs16843918; rs16843892; rs16843879; rs7615203; rs6785225; rs1291921; rs6808143; rs7611416; rs9848883; rs9866840; rs489398; rs7633573; rs11713514; rs12330635; rs6765839; rs6807002; rs9856769; rs3732520; rs9809806; rs2305265; rs518972; rs7615199; rs7615252; rs17265675; rs9829390; rs676237; rs1711170; rs13090330; rs3732521; rs3732519; rs7611507; rs16843829; rs16843806; rs3755636; rs28934887; rs1130114; rs2686559; rs35923895; rs11434447; rs2948153; rs13099771; rs1300031; rs1698984; rs598989; rs556788; rs552098; rs34350990; rs3994934; rs865113; rs7430820; rs11276589; rs570621; rs3913715; rs11421458; rs13067714; rs28848266; rs519766; rs35915403; rs598576; rs711979; rs2971555; rs1720751; rs586381; rs35875406; rs863900; rs1698983; rs10602343; rs9864912; rs11715586; rs1711167; rs480330; rs34690853; rs34167145; rs34943743; rs34551310; rs35316359; rs10524213; rs7613584; rs2689386; rs1298857; rs34031772; rs11916366; rs866782; rs4678429; rs7642585; rs13068199; rs34066658; rs33956304; rs11719796; rs675335; rs9884075; rs680487; rs12330421; rs9812837; rs641415; rs1292281; rs515181; rs2971556; rs12163608; rs36106592; rs2689389; rs517847; rs1279949; rs521775; rs34417976; rs34673387; rs35507003; rs10576866; rs35790151; rs34160582; rs13071533; rs35871807; rs7628146; rs34362321; rs6148083; rs1612376; rs34481240; rs11707791; rs865668; rs28804502; rs35786833; rs1279962; rs9834054; rs35524055; rs34349947; rs610691; rs1097472; rs34947225; rs34864084; rs1711166; rs1667321; rs35582341; rs2971557; rs34864587; rs35322388; rs4317048; rs2103087; rs34976823; rs7618114; rs34038836; rs9872178; rs11385401; rs35681043; rs2971554; rs606725; rs34409113; rs1300014; rs674902; rs1299252; rs1298842; rs34354052; rs35633718; rs34303028; rs36123354; rs35144965; rs13072038; rs3884120; rs35522825; rs4125861; rs1316208; rs4383459; rs865667; rs35228700; rs34511849; rs3994953; rs9852811; rs34106072; rs34726739; rs35227703; rs34153877; rs35942146; rs28812220; rs34428695; rs9871320; rs34974143; rs12633129; rs1300032; rs9872091; rs13071085; rs1720752; rs13067567; rs677825; rs527888; rs35529413; rs34146770; rs35838767; rs10513002; rs11926660; rs13785; rs17199880; rs17199978; rs3894140; rs534944; rs561307; rs610860; rs6439638; rs6783337; rs696520; rs7626261; rs8045; rs9812513

# Metabolic_Enzyme_5_General_References:
8188292; 8225321; 9683601; 3460076; 2154743; 8411997; 10447268; 10502773; 12559849

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5276

# Metabolic_Enzyme_6_Name:
Acetyl-CoA carboxylase 1

# Metabolic_Enzyme_6_Synonyms:
ACC-alpha[Includes: Biotin carboxylase

# Metabolic_Enzyme_6_Gene_Name:
ACACA

# Metabolic_Enzyme_6_Protein_Sequence:
>AcetylCoA carboxylase 1
MDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKEGSLSPASVGSDTLS
DLGISSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEK
VLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPG
GPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWAL
GDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQA
AEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEV
QILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSA
GTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPLYRIKDIRMMY
GVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGY
FSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLIKLLET
ESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRNSVSNFLHSLERGQV
LPAHTLLNTVDVELIYEGVKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDG
SSYTTYMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYA
EIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVLAKMQLDNPSKVQQAELHTGSLPRIQ
STALRGEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQ
DIMTSVSGRIPPNVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREV
FFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSD
MNTVLNYIFSHAQVTKKNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALR
ARQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYH
SNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRM
SFSSNLNHYGMTHVASVSDVLLDNSFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFSDSP
PQSPTFPEAGHTSLYDEDKVPRDEPIHILNVAIKTDCDIEDDRLAAMFREFTQQNKATLV
DHGIRRLTFLVAQKDFRKQVNYEVDRRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQ
LELNRMRNFDLTAIPCANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFE
YLQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYG
SRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQA
YGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQA
FLPSPPLPSDMLTYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVI
GNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGARIGLAEEIRHMFHVAWVD
PEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGS
GMIAGESSLAYNEIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGR
EVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYMPKSVHSSVPLLNSKDPID
RIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGG
IPVGVVAVETRTVELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPL
MVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYIPPQAELRGGSWVVIDSSI
NPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAE
RKELENKLKEREEFLIPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYWRLR
RLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAYVWDNNKDLAEWLEKQLTE
EDGVHSVIEENIKCISRDYVLKQIRSLVQANPEVAMDSIIHMTQHISPTQRAEVIRILST
MDSPST

# Metabolic_Enzyme_6_Number_of_Residues:
2346

# Metabolic_Enzyme_6_Molecular_Weight:
265557

# Metabolic_Enzyme_6_Theoretical_pI:
6.32

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  ligase activity
Function:  vitamin binding
Function:  biotin binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions:biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase

# Metabolic_Enzyme_6_Pathway:
map00061  Fatty acid biosynthesis (path 1);
 map00253  Tetracycline biosynthesis;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_6_Reaction:
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF08326:ACC_central;
PF02785:Biotin_carb_C;
PF00364:Biotin_lipoyl;
PF01039:Carboxyl_trans;
PF00289:CPSase_L_chain;
PF02786:CPSase_L_D2

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 6.4.1.2;EC 6.3.4.14

# Metabolic_Enzyme_6_GenBank_ID_Protein:
849083

# Metabolic_Enzyme_6_SwissProt_ID:
COA1_HUMAN (Q13085)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ACACA

# Metabolic_Enzyme_6_Geneatlas_id:
ACACA

# Metabolic_Enzyme_6_hgnc_id:
HGNC:84

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_6_Gene_Sequence:
>7041 bp
ATGGATGAACCATCTCCCTTGGCCCAACCTCTGGAGCTGAACCAGCACTCTCGATTCATA
ATAGGTTCTGTGTCAGAAGATAACTCAGAGGATGAGATCAGCAACCTGGTGAAGCTGGAC
CTACTGGAGGAGAAGGAGGGCTCCTTGTCACCTGCTTCTGTTGGCTCAGATACACTCTCT
GATTTGGGGATCTCTGCCCTACAGGATGGCTTGGCCTTGCACATAAGGTCCAGCTGGTCT
GGCTTGCACCTAGTAAAGCAGGGCGGAGACAGAAAGAAAATAGATTCTCAACGAGATTTC
ACTGTGGCTTCTCCAGCAGAATTTGTTACTCGCTTTGGGGGAAATAAAGTGATTGAGAAG
GTTCTCATCGCTAACAATGGCATTGCAGCAGTGAAATGCATGCGGTCTATCCGTAGGTGG
TCTTATGAAATGTTTCGAAATGAACGTGCAATTAGATTCGTTGTCATGGTCACACCTGAA
GACCTTAAAGCCAATGCAGAATACATTAAGATGGCAGATCACTATGTGCCGGTGCCTGGA
GGAGCAAACAACAACAACTATGCAAATGTGGAATTAATTCTTGATATTGCTAAAAGGATC
CCAGTGCAAGCAGTGTGGGCTGGCTGGGGTCATGCTTCTGAGAATCCCAAACTACCGGAA
CTTCTCTTGAAAAATGGCATTGCCTTCATGGGTCCTCCAAACCAGGCCATGTGGGCTTTA
GGGGATAAGATTGCATCTTCCATAGTGGCTCAAACTGCAGGTATCCCAACTCTTCCCTGG
AGCGGCAGTGGTCTTCGTGTGGACTGGCAGGAAAATGATTTTTCAAAACGTATCTTAAAT
GTTCCCCAGGAGCTATATGAAAAAGGTTATGTGAAAGATGTGGATGATGGGCTAAAGGCA
GCTGAGAAGGTTGGATATCCAGTAATGATCAAGGCCTCAGAGGGAGGAGGAGGGAAGGGA
ATTAGAAAAGTTAACAATGCAGATGACTTCCCTAATCTCTTCAGACAGGTTCAAGCTGAA
GTTCCTGGATCTCCCATATTTGTGATGAGACTAGCCAAACAATCTCGTCATCTGGAGGTG
CAGATCTTAGCGGACCAATATGGCAATGCTATCTCTTTGTTTGGTCGTGATTGCTCTGTA
CAACGCAGGCATCAGAAGATTATTGAAGAAGCACCTGCTACTATTGCTACTCCAGCAGTA
TTTGAACACATGGAACAGTGTGCGGTGAAACTTGCCAAAATGGTGGGTTATGTGAGTGCT
GGGACTGTGGAATACCTGTACAGCCAGGATGGCAGCTTCTACTTTCTAGAATTGAACCCT
CGGCTACAGGTTGAACAACCTTGTACAGAGATGGTGGCTGATGTCAATCTCCCCGCAGCA
CAGCTCCAGATTGCCATGGGGATTCCTCTATATAGAATCAAGGATATCCGTATGATGTAT
GGGGTATCTCCTTGGGGTGATTCTCCCATTGATTTTGAAAATTCTGCTCACGTTCCTTGT
CCAAGGGGCCATGTTATTGCTGCTCGGATCACTAGTGAAAATCCAGATGAGGGTTTTAAG
CCCAGCTCAGGAACAGTTCAGGAGCTAAATTTCCGCAGCAATAAGAATGTTTGGGGATAT
TTCAGTGTTGCTGCTGCAGGGGGACTTCATGAATTTGCTGGTTCTCAGTTTGGTCACTGC
TTTTCTTGGGGAGAAAACAGAGAAGAAGCAATTTCAAACATGGTGGTGGCATTGAAGGAG
CTGTCTATTCGGGGTGACTTTCGAACTACAGTTGAATACCTGATCAAATTGTTAGAGACT
GAAAGCTTTCAAATGAACAGAATTGATACTGGCTGGCTGGACAGACTGATAGCAGAAAAA
GTACGGGCTGAGCGTCCTGACACCATGTTGGGGGTTGTGTGTGGTGCCCTCCACGTCGGA
GATGTGAGCCTGCGAAATAGCGTCTCTAACTTCCTTCACTCCTTAGAAAGGGGTCAAGTC
CTTCCGGCTCATACACTTCTGAATACAGTAGATGTTGAACTTATCTATGAGGGAGTCAAG
TATGTACTTAAGGTGACTCGACAGTCCCCCAACTCCTATGTGGTGATCATGAATGGCTCA
TGTGTAGAAGTAGATGTACATCGGCTGAGTGACGGTGGACTGCTCTTGTCCTATGATGGC
AGCAGTTACACCACGTATATGAAGGAGGAAGTAGACAGATATCGCATCACAATTGGCAAT
AAAACCTGTGTGTTTGAGAAGGAAAATGACCCATCGGTGATGCGCTCACCTTCTGCTGGG
AAGTTAATCCAGTACATTGTAGAAGATGGAGGTCATGTGTTTGCCGGCCAGTGCTATGCA
GAGATTGAGGTAATGAAGATGGTAATGACTTTGACAGCTGTGGAGTCTGGCTGTATCCAT
TACGTCAAGCGTCCTGGAGCAGCTCTTGACCCTGGCTGTGTACTCGCCAAAATGCAACTG
GACAACCCCAGCAAGGTTCAGCAGGCTGAACTTCACACAGGTAGTCTGCCACGGATCCAG
AGCACCGCTCTCCGAGGCGAGAAGCTCCATCGAGTGTTCCACTATGTCCTGGATAATCTG
GTCAATGTAATGAATGGATACTGCCTTCCAGATCCTTTCTTTAGCAGCAAGGTAAAAGAC
TGGGTAGAACGATTGATGAAAACCCTCAGAGATCCCTCCCTGCCTCTCCTAGAATTGCAA
GATATTATGACCAGTGTGTCTGGCCGCATTCCCCCCAATGTGGAGAAGTCTATCAAGAAG
GAAATGGCTCAGTATGCTAGCAACATCACATCAGTCCTCTGTCAGTTTCCCAGCCAGCAG
ATTGCAAACATCCTAGATAGCCATGCAGCTACATTGAACCGGAAATCTGAACGGGAAGTC
TTCTTTATGAATACTCAGAGCATTGTCCAGCTGGTACAGAGGTACCGAAGTGGCATCCGA
GGCCACATGAAGGCTGTGGTGATGGATCTGCTCCGGCAGTACCTGCGAGTAGAGACACAA
TTCCAGAATGGTCACTATGACAAATGTGTATTCGCCCTTCGAGAAGAGAATAAGAGTGAC
ATGAACACTGTACTGAACTACATCTTCTCTCACGCTCAAGTCACCAAGAAGAATCTTCTG
GTCACAATGCTTATTGATCAGTTGTGTGGCCGGGACCCTACTCTAACTGATGAGCTGCTG
AGTATTCTCACAGAGCTAACTCAACTCAGTAAGACCACCAATGCCAAAGTAGCACTTCGA
GCACGCCAGGTTCTTATTGCCTCCCATTTGCCATCATATGACGTTCGCCATAACCAAGTA
GAGTCTATCTTCCTATCAGCTATTGACATGTATGGACATCAATTTTGCATTGAGAACCTG
CAGAAACTCATCCTATCAGAAACATCTATTTTTGATGTCCTACCAAACTTCTTCTATCAC
AGCAACCAAGTAGTGAGGATGGCAGCTCTGGAGGTGTACGTTCGAAGGGCTTATATTGCC
TATGAACTTAACAGCGTACAACACCGCCAGCTTAAGGACAACACCTGCGTGGTGGAATTC
CAGTTCATGCTGCCCACATCTCATCCAAACAGAGGGAACATCCCTACGCTAAACAGAATG
TCCTTCTCCTCCAACCTCAACCACTATGGCATGACCCATGTAGCTAGTGTCAGCGATGTT
CTGTTGGACAACGCCTTCACACCACCTTGTCAACGCATGGGCGGAATGGTCTCTTTTCGG
ACTTTTGAAGATTTTGTCAGGATCTTTGATGAAGTAATGGGCTGCTTCTGTGACTCCCCA
CCCCAGAGTCCCACATTCCCTGAGGCAGGTCACACGTCTCTTTATGATGAGGATAAGGTT
CCCAGGGATGAACCAATTCACATTCTCAATGTGGCTATCAAGACTGACGGTGATATTGAG
GATGACAGGCTGGCAGCTATGTTCAGAGAATTCACCCAGCAAAATAAAGCTACCCTGGCT
GACCATGGGATCCGGCGCCTGACTTTCCTGGTTGCACAAAAGGATTTCAGAAAGCAGGTC
AACTATGAGGTGGATCGGAGATTTCATAGAGAATTCCCTAAATTTTTTACATTCCGAGCA
AGGGATAAGTTTGAGGAGGATCGTATCTATCGTCATCTGGAGCCTGCTCTGGCTTTCCAG
TTAGAGCTGAACCGGATGAGAAATTTTGACCTCACTGCCATTCCATGTGCTAATCACAAG
ATGCACCTGTATCTCGGGGCAGCCAAGGTGGAAGTGGGCACAGAAGTGACAGACTACAGG
TTCTTTGTTCGTGCAATCATCAGGCATTCTGATCTGGTCACCAAGGAAGCTTCTTTTGAA
TATCTGCAAAGTGAAGGGGAGCGGCTACTCCTGGAAGCCATGGATGAGTTGGAAGTTGCT
TTTAACAATACAAATGTCCGCACTGACTGTAACCACATCCTCCTCAACTTTGTGCCCACG
GTTATCATGGACCCATCAAAGATTGAGGAATCCGTGCGGAGCATGGTAATGCGGTATGGA
AGTCGCCTGTGGAAATTGCGCGTCCTCCAGGCAGAACTGAAAATCAACATTCGCCTGACG
CCAACTGGAAAAGCAATTCCCATCCGCCTTTTCCTGACAAACGAGTCTGGCTATTACTTG
GATATCAGCCTATACAAGGAAGTGACTGACTCCAGGACAGCACAGATCATGTTTCAGGCA
TATGGAGACAAGCAGGGACCACTGCATGGAATGTTAATCAATACTCCATATGTGACCAAA
GACCTGCTGCAATCAAAGAGGTTCCAGGCACAATCCTTAGGGACAACGTACATATATGAT
ATCCCAGAGATGTTTCGGCAGTCCCTGATCAAACTCTGGGAGTCTATGTCAACTCAAGCA
TTTCTTCCATCTCCCCCTCTGCCTTCTGACATGCTGACTTACACTGAACTGGTACTGGAT
GATCAAGGTCAGCTGGTCCACATGAACAGGCTTCCAGGAGGAAATGAGATTGGCATGGTA
GCTTGGAAAATGAGCCTTAAAAGTCCTGAATATCCAGAAGGCCGAGATGTTATTGTTATT
GGCAATGACATTACATACCGAATTGGGTCCTTTGGGCCTCAAGAAGATTTGTTATTTCTC
AGAGCTTCCGAACTTGCTAGGGCCGAAGGCATTCCACGCATCTATGTATCAGCCAACAGT
GGAGCAAGAATCGGACTGGCAGAAGAAATTCGCCATATGTTTCATGTGGCCTGGGTAGAT
TCTGAGGATCCTTACAAGGGATACAGGTATTTATATCTGACTCCTCAAGATTATAAGAGA
GTCGGTGCTCTCAACTCTGTCCATTGTGAACACGTGGAAGATGAAGGAGAATCCAGGTAC
AAGATAACAGATATTATTGGGAAAGAAGAGGGAATTGGACCCGAGAACCTTCGAGGTTCT
GGAATGATCGCTGGAGAATCCTCATTGGCCTATAATGAGATCATTACCATCAGCCTGGTG
ACGTCCCGGGCCATTGGGATTGGGGCTTACCTTGTCCGGCTGGGACAGAGAACCATCCAG
GTTGAGAATTCTCACTTGATTCTAACAGGAGCTGGAGCCCTCAACAAAGTCCTCGGGCGG
GAAGTGTACACCTCCAATAACCAGCTGGGGGGCATCCAGATTACGCACAACAATGGGGTG
ACCCACTGCACTGTGTGTGACGGCTTTGAAGGGGTTTTCACTGTCCTGCACTGGCTGTCT
TACATGCCCAAGAGCGTACACAGTTCAGTTCCTCTTCTGAACTCAAAGGATCCTATAGAC
AGAATCATCGAGTTTGTTCCCACAAAGACCCCATATGATCCTCGATGGATGCTAGCAGGC
CGCCCTCACCCAACCCAAAAAGGTCAGTGGTTGAGTGGCTTTTTTGACTATGGATCTTTC
TCAGAGATTATGCAGCCCTGGGCACAGACGGTGGTGGTTGGTAGAGCCAGGTTAGGGGGA
ATACCTGTGGGAGTTGTTGCTGTAGAAACCCGGACAGTAGAACTAAGTGTACCAGCTGAT
CCAGCAAACCTGGATTCTGAAGCCAAGATAATCCAGCACGCCGGCCAAGTTTGGTTTCCG
GATTCTGCGTTTAAGACGTATCAGGCCATCAAGGACTTCAACCGGGAAGGGCTACCTCTA
ATGGTCTTTGCCAACTGGAGAGGCTTCTCTGGTGGAATGAAAGATATGTATCACCAAGTG
CTGAAGTTTGGTGCTTACATTGTGGATGGCTTGCGGGAATGTTCCCAGCCTGTGCTGGTC
TACATTCCTCCCCAGGCTGAGCTGCGGGGTGGCTCCTGGGTGGTGATCGACCCAACCATC
AATCCTCGGCACATGGAGATGTATGCTGACCGAGAAAGCAGGGGATCTGTTCTGGAGCCA
GAAGGGACGGTAGAAATCAAATTCCGCAGAAAGGATCTGGTGAAAACCATGCGTCGGGTG
GACCCAGTCTACATCCACTTGGCTGAGCGATTGGGGACCCCAGAGCTGAGCCCAACTGAG
CGGAAGGAGTTGGAGAGCAAGTTGAAGGAGCGGGAGGAATTCCTAATTCCAATTTACCAT
CAGGTAGCCGTGCAGTTTGCTGACTTGCACGACACTCCAGGCCGGATGCAGGAGAAGGGT
GTTATTAGCGATATCCTGGATTGGAAAACATCCCGTACCTTCTTCTACTGGCGACTGAGG
CGTCTTCTGCTGGAGGACCTGGTCAAGAAGAAAATCCACAGTGCCAACCCTGAGCTGACT
GATGGCCAGATTCAAGCCATGTTAAGACGCTGGTTTGTGGAAGTGGAAGGAACAGTGAAG
GCTTATGTTTGGGACAATAATAAGGATCTGGCGGAGTGGCTAGAGAAACAGCTGACAGAG
GAGGATGGTGTTCACTCGGTAATAGAGGAAAACATCAAATGCATCAGCAGAGACTACGTC
CTCAAGCAAATCCGCAGCTTGGTCCAGGCCAATCCAGAGGTTGCCATGGATTCCATCATC
CATATGACGCAGCACATATCACCCACTCAGCGGGCAGAAGTCATAAGGATCCTTTCCACT
ATGGACTCCCCTTCTACGTAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
U19822

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_6_Locus:
17q21

# Metabolic_Enzyme_6_SNPs:
rs2229416; rs2946342; rs1464255; rs878520; rs7216136; rs2542668; rs11656221; rs829168; rs1464257; rs829157; rs4795194; rs1464256; rs712038; rs2946537; rs12948120; rs1714996; rs954673; rs8076591; rs829160; rs9893734; rs829161; rs829156; rs12452294; rs2542666; rs2030314; rs6607369; rs829162; rs12451927; rs11869216; rs2049038; rs712037; rs7225031; rs17841479; rs1473626; rs9913481; rs9895936; rs1112174; rs8080851; rs12942424; rs8080375; rs8078306; rs17139041; rs8066509; rs9907598; rs8065658; rs8076589; rs9898293; rs9891762; rs4795193; rs2542670; rs829151; rs9898680; rs7223837; rs7222669; rs1715000; rs11871085; rs4500789; rs829167; rs17138792; rs11650095; rs11649798; rs7406300; rs7224009; rs9910658; rs8065811; rs9904519; rs2090603; rs7211305; rs12453651; rs7501676; rs11868780; rs9902736; rs9913542; rs8079644; rs9915232; rs12952401; rs7502962; rs1096038; rs8072619; rs2542665; rs1268567; rs2302800; rs2590728; rs1266182; rs2246459; rs2542653; rs2542660; rs1266180; rs895245; rs1878941; rs2680395; rs1900101; rs2121017; rs2898659; rs2255527; rs2542662; rs1266175; rs2680398; rs2017571; rs9286331; rs725038; rs2053670; rs11652379; rs9789070; rs9897583; rs2680392; rs9912138; rs2542663; rs11653028; rs11650464; rs3816309; rs2302803; rs7215365; rs9909876; rs9330250; rs4572453; rs2248509; rs7215615; rs3815059; rs1445487; rs9903451; rs8072064; rs10908287; rs7219583; rs6607364; rs2542659; rs7208613; rs9900363; rs7207026; rs9895998; rs9330249; rs9901601; rs2254914; rs1519091; rs4299194; rs7221404; rs8076694; rs3785948; rs12450937; rs2542655; rs7219671; rs12449696; rs4795190; rs4794753; rs12451365; rs2285655; rs8081866; rs7222524; rs11650327; rs7222727; rs2680400; rs9906543; rs11263823; rs9891423; rs2921368; rs17841492; rs2287352; rs4795181; rs9330251; rs7221195; rs11659129; rs2680399; rs9330248; rs4794750; rs7211430; rs11655013; rs2305097; rs17573357; rs7214025; rs10512477; rs11263824; rs2245093; rs2909264; rs8077266; rs2106772; rs3744589; rs11651239; rs12603098; rs11653093; rs7208053; rs11869869; rs2271855; rs12719988; rs2542654; rs11263825; rs12150477; rs17249662; rs17574651; rs4523972; rs9902961; rs9908334; rs12951598; rs2542661; rs9891027; rs17138930; rs7215485; rs2305099; rs17138934; rs3848462; rs4795189; rs2305098; rs10512478; rs12453407; rs12103832; rs1878942; rs2252757; rs3817376; rs34565612; rs17138898; rs12940254; rs2542652; rs7207912; rs1634334; rs7208404; rs4325613; rs8066577; rs7211788; rs4795182; rs8074739; rs4795172; rs2018578; rs2542656; rs12938125; rs9899403; rs9912155; rs1634335; rs4795177; rs12452907; rs8071957; rs17138899; rs2542664; rs8079975; rs11871055; rs1266183; rs12946127; rs17573893; rs8081936; rs2542657; rs17138804; rs2245066; rs2680394; rs2680402; rs8080705; rs9910098; rs7212022; rs7225778; rs9889428; rs4795180; rs9904710; rs8080136; rs17148; rs2049037; rs12945106; rs1266181; rs17138935; rs7224248; rs8078027; rs9914270; rs12603373; rs17695209; rs4795188; rs34196517; rs8079659; rs2680390; rs4795178; rs12603097; rs1266184; rs9910582; rs9652902; rs2278679; rs2542651; rs9915979; rs12601872; rs7208415; rs9899506; rs8072607; rs8071315; rs4473247; rs17652319; rs11263822; rs2680401; rs8071882; rs10153271; rs9915088; rs12601074; rs8082438; rs9895266; rs8068286; rs7221648; rs8068285; rs9893030; rs8068136; rs17841494; rs17138999; rs9630753; rs8072177; rs8078876; rs17139011; rs1634333; rs4795179; rs11867576; rs9899159; rs7502022; rs9905678; rs9906044; rs732770; rs17848757; rs17848759; rs2287351; rs1057349; rs1470452; rs2302802; rs1057347; rs1057348; rs1057350; rs8078349; rs4795192; rs1714623; rs35720275; rs9904194; rs3177098; rs11871196; rs2946344; rs11268107; rs28477683; rs12947290; rs11374277; rs1714619; rs11871581; rs9898204; rs35858056; rs9903488; rs5820211; rs1714994; rs9890038; rs11650629; rs5017481; rs35707017; rs7215677; rs35449295; rs8075744; rs7502476; rs35218514; rs9911273; rs8073540; rs35127394; rs7406337; rs34322212; rs1714999; rs35940399; rs11436121; rs34122401; rs36037660; rs34553247; rs9905514; rs35089144; rs12451158; rs11442383; rs9902122; rs35244497; rs10638342; rs35613288; rs1714614; rs1714628; rs7220707; rs12103707; rs11433722; rs35767845; rs35037307; rs35348805; rs34046448; rs34748698; rs9890298; rs34538373; rs5820212; rs2411158; rs35737118; rs9909611; rs12948635; rs2030285; rs8073434; rs12451423; rs35250857; rs35643626; rs7212437; rs12939217; rs34849930; rs35218812; rs12951107; rs3214149; rs11657433; rs1714622; rs35280698; rs35296298; rs12951195; rs35287948; rs853333; rs9912715; rs34732682; rs2542669; rs8064856; rs34680925; rs35438041; rs34937393; rs34068224; rs35921490; rs34937895; rs35348280; rs12938337; rs8080102; rs11452189; rs34866388; rs11291539; rs34308874; rs34550633; rs12939093; rs28601768; rs3197958; rs7350918; rs1714613; rs35610236; rs11653615; rs11327792; rs1102920; rs34530185; rs12944932; rs12945602; rs35059960; rs11409136; rs11557526; rs35451821; rs12945037; rs9914773; rs829158; rs35341859; rs34762337; rs11867736; rs865491; rs11871794; rs7502448; rs36034193; rs2680397; rs35040059; rs11658403; rs35046713; rs12952788; rs35309005; rs28621473; rs9900503; rs28559981; rs11658965; rs6607367; rs35706744; rs2285654; rs1112173; rs829159; rs11415508; rs35754179; rs17575843; rs35907016; rs2946343; rs1714624; rs34855609; rs5820210; rs34804632; rs7350920; rs1096037; rs35982452; rs1714998; rs2542667; rs34434804; rs12947603; rs11263826; rs7215696; rs12939724; rs829166; rs35728907; rs2898658; rs9906090; rs9903691; rs7213581; rs34384471; rs4795176; rs11654466; rs36094533; rs2542650; rs17848793; rs9890317; rs12942615; rs36093723; rs4570909; rs35053139; rs10645751; rs35471229; rs10671588; rs8076806; rs3841372; rs9898937; rs11347340; rs9915785; rs34671149; rs35248132; rs17848784; rs12949088; rs35230979; rs35061044; rs9900876; rs4795175; rs35956114; rs1271488; rs10568449; rs9674488; rs2411159; rs8075779; rs35737781; rs12947676; rs34458625; rs17848762; rs34182921; rs28477777; rs12941070; rs28698959; rs4510071; rs28528949; rs12949085; rs11303351; rs34482887; rs35220171; rs7212002; rs35538188; rs7214764; rs35098874; rs1634339; rs34489372; rs34997067; rs17848797; rs12942721; rs17848788; rs34367681; rs1664309; rs9914608; rs11299899; rs939129; rs36021448; rs35499336; rs35872142; rs5820208; rs12939415; rs17848771; rs3049593; rs12951401; rs35332296; rs35493433; rs11399349; rs10671587; rs2542658; rs1634340; rs11655089; rs11336184; rs35050543; rs35959861; rs11656682; rs35181821; rs35888166; rs34622871; rs1052813; rs8066905; rs34848337; rs34889497; rs35120204; rs1269928; rs34019734; rs28718742; rs11344097; rs7221916; rs36041619; rs17848758; rs28715486; rs12936609; rs6607365; rs34165656; rs10690897; rs2590729; rs3896990; rs35784797; rs11658519; rs34419580; rs9907032; rs2680393; rs5011489; rs1664313; rs2440930; rs9909663; rs35278959; rs34556010; rs36038126; rs7224720; rs11316017; rs12162164; rs8069192; rs35944181; rs35601261; rs9909209; rs34982826; rs34820331; rs36029062; rs34711647; rs12951295; rs10668354; rs35110941; rs17848785; rs11869067; rs28758642; rs35803116; rs1664312; rs9789078; rs7503749; rs4283266; rs4795173; rs28469706; rs7218958; rs12936483; rs17848760; rs12451360; rs12937002; rs34788014; rs28433321; rs3914775; rs35990848; rs11380975; rs34325998; rs2946338; rs9896763; rs33998928; rs17848782; rs10631083; rs1272399; rs11872016; rs1664308; rs9916468; rs12938356; rs11454831; rs12601087; rs34202919; rs34870931; rs34045470; rs36040010; rs35115636; rs11658482; rs1664307; rs34200410; rs9897866; rs9891120; rs7222011; rs35381652; rs34417650; rs17848773; rs12937687; rs11449332; rs36012737; rs28601670; rs1664310; rs34867690; rs35646199; rs10552606; rs35904405; rs17848777; rs34828277; rs35067909; rs17848791; rs17848779; rs34360478; rs34819116; rs34347402; rs35596715; rs28637322; rs1634336; rs35355755; rs5820207; rs12949895; rs11415930; rs1634341; rs3049582; rs9891493; rs35820505; rs9914412; rs10533480; rs10531552; rs34797415; rs28422855; rs36094882; rs9914097; rs4395121; rs12949666; rs2218492; rs34390024; rs35212343; rs10528744; rs11399968; rs12949301; rs1829409; rs12373130; rs4795184; rs35895326; rs12603225; rs35132757; rs35607802; rs34376457; rs28407410; rs11387933; rs34462409; rs9709110; rs35355558; rs34324549; rs4141321; rs11655124; rs4794751; rs35480307; rs12949893; rs34204061; rs1269929; rs11353672; rs12948010; rs11290127; rs35902268; rs34687448; rs17848794; rs35051577; rs10559180; rs36049042; rs11655018; rs9896459; rs10671586; rs10533479; rs5820209; rs35953832; rs1664311; rs12162162; rs2590727; rs4794752; rs4795174; rs17841491; rs9889809; rs28690443; rs34915260; rs17848765; rs34202102; rs17848792; rs35340914; rs5820206; rs1664306; rs17848781; rs1634337; rs28562944; rs12943917; rs1634342; rs2302801; rs8081655; rs11276038; rs35654179; rs2680391; rs34347667; rs35927365; rs7216802; rs34888479; rs28479986; rs4794749; rs35005664; rs28729196; rs34064045; rs4313849; rs17848775; rs34370484; rs9908693; rs3217177; rs28536028; rs34847496; rs34102178; rs35977079; rs36105403; rs12938721; rs12947675; rs34306905; rs10664252; rs4795170; rs28481702; rs1634338; rs9913086; rs34260630; rs34732750; rs11649942; rs12950056; rs34587818; rs9891491; rs2411160; rs17848783; rs35737566; rs34799022; rs35653728; rs7215793; rs11655157; rs35123372; rs12942719; rs2680396; rs1822944; rs11353673; rs35748619; rs12943201; rs8079157; rs11315644; rs12950440; rs5820205; rs34978266; rs36103499; rs1046873; rs11656455; rs11867460; rs11871275; rs12601443; rs12938498; rs1681809; rs17138766; rs1714986; rs1714987; rs1822941; rs1822942; rs1822943; rs2005356; rs2005357; rs2411161; rs2946340; rs34232224; rs7211875; rs7224522; rs8066442; rs8068303; rs8073074; rs8082190; rs829163; rs829164; rs829165; rs873409; rs873410; rs9890344; rs9916113

# Metabolic_Enzyme_6_General_References:
7732023; 12810950

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5817

# Metabolic_Enzyme_7_Name:
Biotinidase precursor

# Metabolic_Enzyme_7_Synonyms:
Not Available

# Metabolic_Enzyme_7_Gene_Name:
BTD

# Metabolic_Enzyme_7_Protein_Sequence:
>Biotinidase precursor
MSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVAAVYEHPSILSLNPLALISRQ
EALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPQVVRW
NPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCHSSDPRCPKDGRYQFNTNVVF
SNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRFGIFTCFDILFFDPAIRVLRD
YKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAANVHHPVLGMTGSGIHTPLESF
WYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSKFLKILSGDPYCEKDAQEVHC
DEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSNGLCCYLLYERPTLSKELYAL
GVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATGIFEFHLWGNFSTSYIFPLFL
TSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLYERD

# Metabolic_Enzyme_7_Number_of_Residues:
523

# Metabolic_Enzyme_7_Molecular_Weight:
58914

# Metabolic_Enzyme_7_Theoretical_pI:
5.72

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  nitrogen compound metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation

# Metabolic_Enzyme_7_Pathway:
map00780  Biotin metabolism

# Metabolic_Enzyme_7_Reaction:
biotin amide + H2O = biotin + NH3

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00795:CN_hydrolase

# Metabolic_Enzyme_7_Signals:
1-21

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.5.1.12

# Metabolic_Enzyme_7_GenBank_ID_Protein:
468824

# Metabolic_Enzyme_7_SwissProt_ID:
BTD_HUMAN (P43251)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
BTD

# Metabolic_Enzyme_7_Geneatlas_id:
BTD

# Metabolic_Enzyme_7_hgnc_id:
HGNC:1122

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_7_Gene_Sequence:
>1632 bp
ATGGCGCATGCGCATATTCAGGGCGGAAGGCGCGCTAAGAGCAGATTTGTGGTCTGCATT
ATGTCTGGAGCCAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTG
GGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGAGGCTGAATATTATGTGGCT
GCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAA
GAGGCCTTGGAGCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCA
GCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGGCATTCATGGATTCAACTTT
ACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGG
AACCCATGCCTGGAGCCTCACCGCTTCAATGACACAGAGGTGCTCCAGCGCCTGAGTTGT
ATGGCCATCAGGGGAGATATGTTCTTGGTGGCCAATCTTGGGACAAAGGAGCCTTGTCAT
AGCAGTGACCCAAGGTGCCCAAAAGATGGGAGATACCAGTTCAACACAAATGTCGTGTTC
AGCAATAATGGAACCCTTGTTGACCGCTACCGTAAACACAACCTCTACTTTGAGGCAGCA
TTCGATGTTCCTCTTAAAGTGGATCTCATCACCTTTGATACCCCCTTTGCTGGCAGGTTT
GGCATCTTCACATGCTTTGATATATTGTTCTTTGACCCTGCCATCAGAGTCCTCAGAGAC
TACAAGGTGAAGCATGTTGTGTACCCAACTGCCTGGATGAACCAGCTCCCACTCTTGGCA
GCAATTGAGATTCAGAAAGCTTTTGCTGTTGCCTTTGGCATCAACGTTCTGGCAGCTAAT
GTCCACCACCCAGTTCTGGGGATGACAGGAAGTGGCATACACACCCCTCTGGAGTCCTTT
TGGTACCATGACATGGAAAATCCCAAAAGTCACCTTATAATTGCCCAGGTGGCCAAAAAT
CCAGTGGGTCTCATTGGTGCAGAGAATGCAACAGGTGAAACGGACCCATCCCATAGTAAG
TTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCACTGT
GATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTAT
GACAATTTCACCCTGGTCCCTGTCTGGGGAAAGGAAGGCTATCTCCACGTCTGTTCCAAT
GGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCCCTG
GGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTG
GTCAGGTGTGGGGGTCTTGGCTTCGACACCTGCGGACAGGAAATCACAGAGGCCACGGGG
ATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTTCTG
ACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTC
CTGAGGAAAAGTAGGCTGTCCTCTGGGCTGGTGACGGCGGCTCTCTATGGGCGCTTGTAT
GAGAGGGACTAG

# Metabolic_Enzyme_7_GenBank_ID_Gene:
U03274

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_7_Locus:
3p25

# Metabolic_Enzyme_7_SNPs:
rs35034250; rs13078881; rs3817641; rs924814; rs2471809; rs2455826; rs4094397; rs2455820; rs9853116; rs2455810; rs1021849; rs2455916; rs9880034; rs4478067; rs2280770; rs13320591; rs760066; rs2471807; rs11128749; rs7651039; rs6773682; rs2455827; rs2470526; rs12489825; rs2455823; rs2470529; rs2455915; rs10510441; rs13319547; rs741747; rs741748; rs9858977; rs9310480; rs9866477; rs1296433; rs2734308; rs9858784; rs7640807; rs34356435; rs9310481; rs9849809; rs10212184; rs12330387; rs7621332; rs4626087; rs9827673; rs4309707; rs9825546; rs2455828; rs9310479; rs9830528; rs17041367; rs2470551; rs12639040; rs6807875; rs9836533; rs2174267; rs28934601; rs35976361; rs13073139; rs34885143; rs35145938; rs28475858; rs28612795; rs2055564; rs9838247; rs13066152; rs12494340; rs11714810; rs34101231; rs34976221; rs11916854; rs2471806; rs4298027; rs2470528; rs2455918; rs6803821; rs12493340; rs35141065; rs35452512; rs2470541; rs2654647; rs12631444; rs2455825; rs13068169; rs9873582; rs13075998; rs35719864; rs4685254; rs2734309; rs35863533; rs35004427; rs10621505; rs28576968; rs36065590; rs11915606; rs12330789; rs4407396; rs11717801; rs13088542; rs9755; rs35369543; rs7620644; rs9825684; rs4582034; rs35742912; rs28450862; rs28758269; rs34826323; rs7429324; rs2470527; rs13099874; rs35741795; rs34655059; rs9867921; rs36018115; rs2455822; rs2455824; rs28374257; rs6800368; rs1504098; rs1875798; rs2455917; rs9882597; rs11369757; rs11405819; rs6773959; rs35402548; rs9838246; rs34597886; rs36078683; rs35244780; rs2455821; rs35735277; rs9847991; rs9840496; rs34143777; rs34795748; rs2280771; rs12488812; rs34408221; rs28553993; rs9868928; rs9870498; rs35638740; rs13061544; rs34718841; rs35175965; rs2470525; rs4684257; rs36053401; rs11918810; rs12490588; rs13076664; rs13076834; rs13076843; rs13099347; rs1504099; rs2004783; rs2014933; rs2019160; rs2089054; rs2134784; rs2279841; rs2455852; rs2455853; rs2455854; rs2470530; rs2470531; rs2470532; rs2734307; rs3732720; rs3796302; rs3796305; rs6773994; rs6784844; rs6804782; rs7626148; rs869569; rs905555; rs9647358; rs9830541; rs9834785; rs9879788

# Metabolic_Enzyme_7_General_References:
7509806; 9530634; 9099842; 9654207

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5491

# Metabolic_Enzyme_8_Name:
Propionyl-CoA carboxylase alpha chain, mitochondrial precursor

# Metabolic_Enzyme_8_Synonyms:
PCCase subunit alpha; Propanoyl-CoA:carbon dioxide ligase subunit alpha

# Metabolic_Enzyme_8_Gene_Name:
PCCA

# Metabolic_Enzyme_8_Protein_Sequence:
>PropionylCoA carboxylase alpha chain, mitochondrial precursor
MLSAALRTLKHVLYYSRQCLMVSRNLGSVGYDPNEKTFDKILVANRGEIACRVIRTCKKM
GIKTVAIHSD
VDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYG
FLSENKEFARCLAAEDVVFIG
PDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGVVKDAE
EAVRIAREIGYPVMIKASAGGGGKGMRIAWDD
EETRDGFRLSSQEAASSFGDDRLLIEK
FIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPS
IFLDAETRRAMGEQAV
ALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIR
VAKGY
PLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPLHLPGVRVDSGIQPGSD
ISIYY
DPMISKLITYGSDRTEALKRMADALDNYVIRGVTHNIALLREVIINSRFVKGDI
STKFLSDVYPDGFKGH
MLTKSEKNQLLAIASSLFVAFQLRAQHFQENSRMPVIKPDIAN
WELSVKLHDKVHTVVASNNGSVFSVEV
DGSKLNVTSTWNLASPLLSVSVDGTQRTVQCL
SREAGGNMSIQFLGTVYKVNILTRLAAELNKFMLEKVT
EDTSSVLRSPMPGVVVAVSVK
PGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGEGDLLV
ELE

# Metabolic_Enzyme_8_Number_of_Residues:
703

# Metabolic_Enzyme_8_Molecular_Weight:
77355

# Metabolic_Enzyme_8_Theoretical_pI:
7.07

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  ligase activity
Function:  vitamin binding
Function:  biotin binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
ATP + propanoyl-CoA + HCO(3)(-) = ADP + phosphate + (S)-methylmalonyl-CoA

# Metabolic_Enzyme_8_Pathway:
map00280  Valine, leucine and isoleucine degradation;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_8_Reaction:
ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF02785:Biotin_carb_C;
PF00364:Biotin_lipoyl;
PF00289:CPSase_L_chain;
PF02786:CPSase_L_D2

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 6.4.1.3

# Metabolic_Enzyme_8_GenBank_ID_Protein:
296366

# Metabolic_Enzyme_8_SwissProt_ID:
PCCA_HUMAN (P05165)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
PCCA

# Metabolic_Enzyme_8_Geneatlas_id:
PCCA

# Metabolic_Enzyme_8_hgnc_id:
HGNC:8653

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_8_Gene_Sequence:
>2112 bp

ATGCTGAGCGCGGCGCTGCGGACCCTGAAGCATGTTCTGTACTATTCAAGACAGTGCTT
AATGGTGTCCC
GTAATCTTGGTTCAGTGGGATATGATCCTAATGAAAAAACTTTTGATA
AAATTCTTGTTGCTAATAGAGG
AGAAATTGCATGTCGGGTTATTAGAACTTGCAAGAAG
ATGGGCATTAAGACAGTTGCCATCCACAGTGAT
GTTGATGCTAGTTCTGTTCATGTGAA
AATGGCGGATGAGGCTGTCTGTGTTGGCCCAGCTCCCACCAGTA
AAAGCTACCTCAACA
TGGATGCCATCATGGAAGCCATTAAGAAAACCAGGGCCCAAGCTGTACATCCAGG
TTAT
GGATTCCTTTCAGAAAACAAAGAATTTGCCAGATGTTTGGCAGCAGAAGATGTCGTTTTC
ATTGGA
CCTGACACACATGCTATTCAAGCCATGGGCGACAAGATTGAAAGCAAATTATT
AGCTAAGAAAGCAGAGG
TTAATACAATCCCTGGCTTTGATGGAGTAGTCAAGGATGCAG
AAGAAGCTGTCAGAATTGCAAGGGAAAT
TGGCTACCCTGTCATGATCAAGGCCTCAGCA
GGTGGTGGTGGGAAAGGCATGCGCATTGCTTGGGATGAT
GAAGAGACCAGGGATGGTTT
TAGATTGTCATCTCAAGAAGCTGCTTCTAGTTTTGGCGATGATAGACTAC
TAATAGAAA
AATTTATTGATAATCCTCGTCATATAGAAATCCAGGTTCTAGGTGATAAACATGGGAATG
C
TTTATGGCTTAATGAAAGAGAGTGCTCAATTCAGAGAAGAAATCAGAAGGTGGTGGAG
GAAGCACCAAGC
ATTTTTTTGGATGCGGAGACTCGAAGAGCGATGGGAGAACAAGCTGT
AGCTCTTGCCAGAGCAGTAAAAT
ATTCCTCTGCTGGGACCGTGGAGTTCCTTGTGGACT
CTAAGAAGAATTTTTATTTCTTGGAAATGAATAC
AAGACTCCAGGTTGAGCATCCTGTC
ACAGAATGCATTACTGGCCTGGACCTAGTCCAGGAAATGATCCGT
GTTGCTAAGGGCTA
CCCTCTCAGGCACAAACAAGCTGATATTCGCATCAACGGCTGGGCAGTTGAATGTC
GGG
TTTATGCTGAGGACCCCTACAAGTCTTTTGGTTTACCATCTATTGGGAGATTGTCTCAGT
ACCAAGA
ACCGTTACATCTACCTGGTGTCCGAGTGGACAGTGGCATCCAACCAGGAAGT
GATATTAGCATTTATTAT
GATCCTATGATTTCAAAACTAATCACATATGGCTCTGATAG
AACTGAGGCACTGAAGAGAATGGCAGATG
CACTGGATAACTATGTTATTCGAGGTGTTA
CACATAATATTGCATTACTTCGAGAGGTGATAATCAACTC
ACGCTTTGTAAAAGGAGAC
ATCAGCACTAAATTTCTCTCCGATGTGTATCCTGATGGCTTCAAAGGACAC
ATGCTAAC
CAAGAGTGAGAAGAACCAGTTATTGGCAATAGCATCATCATTGTTTGTGGCATTCCAGTT
AA
GAGCACAACATTTTCAAGAAAATTCAAGAATGCCTGTTATTAAACCAGACATAGCCA
ACTGGGAGCTCTC
AGTAAAATTGCATGATAAAGTTCATACCGTAGTAGCATCAAACAAT
GGGTCAGTGTTCTCGGTGGAAGTT
GATGGGTCGAAACTAAATGTGACCAGCACGTGGAA
CCTGGCTTCGCCCTTATTGTCTGTCAGCGTTGATG
GCACTCAGAGGACTGTCCAGTGTC
TTTCTCGAGAAGCAGGTGGAAACATGAGCATTCAGTTTCTTGGTAC
AGTGTACAAGGTG
AATATCTTAACCAGACTTGCCGCAGAATTGAACAAATTTATGCTGGAAAAAGTGACT
GA
GGACACAAGCAGTGTTCTGCGTTCCCCGATGCCCGGAGTGGTGGTGGCCGTCTCTGTCAA
GCCTGGAG
ACGCGGTAGCAGAAGGTCAAGAAATTTGTGTGATTGAAGCCATGAAAATGC
AGAATAGTATGACAGCTGG
GAAAACTGGCACGGTGAAATCTGTGCACTGTCAAGCTGGA
GACACAGTTGGAGAAGGGGATCTGCTCGTG
GAGCTGGAATGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X14608

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:13

# Metabolic_Enzyme_8_Locus:
13q32

# Metabolic_Enzyme_8_SNPs:
rs16957356; rs538229; rs2390383; rs2039677; rs945884; rs1283280; rs2254579; rs1296332; rs681561; rs1556799; rs2760308; rs2893018; rs767282; rs1890139; rs767281; rs675342; rs2783228; rs837335; rs837332; rs2184970; rs1889681; rs2038672; rs2760306; rs1556801; rs2043347; rs1034266; rs3783169; rs7989467; rs9518035; rs2281709; rs7335573; rs1283289; rs2893025; rs9300589; rs7983901; rs4772284; rs6491551; rs733275; rs2152881; rs4489854; rs2277437; rs9518016; rs9300602; rs7333958; rs6491547; rs7997808; rs7990105; rs4772302; rs3902595; rs7492217; rs9518017; rs6491555; rs6491561; rs7991183; rs2253546; rs4499105; rs9585372; rs9585448; rs7983459; rs4772293; rs2783226; rs11069395; rs6491564; rs1000160; rs11839967; rs1297355; rs1112044; rs837325; rs8002078; rs7998989; rs9300597; rs4772278; rs4772300; rs2783230; rs2390465; rs7997125; rs9518060; rs7322595; rs2783212; rs837324; rs3783172; rs4772292; rs2277436; rs9585348; rs7981326; rs12583282; rs7984538; rs7998080; rs4306370; rs6491544; rs7333362; rs7996215; rs4772291; rs6491563; rs11069396; rs4772268; rs6491567; rs7990780; rs2783224; rs9300598; rs9518081; rs7318781; rs9557426; rs9513740; rs4772270; rs2390399; rs837322; rs9557399; rs684215; rs2390402; rs9513735; rs9585387; rs7339265; rs10851114; rs9554686; rs9518053; rs837290; rs2057447; rs2484360; rs9743146; rs2150883; rs1298169; rs9554681; rs7984311; rs2146653; rs2184382; rs9557432; rs3783171; rs7982776; rs6491566; rs9585385; rs1283292; rs9518011; rs7326758; rs1888839; rs7328935; rs2390401; rs9513736; rs9557398; rs8001633; rs4772271; rs2783222; rs837323; rs4771357; rs6491562; rs6491554; rs4772265; rs1415685; rs9585449; rs7318874; rs1298507; rs8002928; rs2039679; rs9518077; rs11069401; rs12428848; rs7326712; rs9518047; rs3783174; rs9557397; rs1298919; rs7989679; rs1745799; rs3825505; rs1292969; rs7991251; rs12708381; rs1415684; rs837292; rs1556800; rs9300591; rs4771360; rs12431036; rs837318; rs6491560; rs9518049; rs7325804; rs12100240; rs9554684; rs6491565; rs9300586; rs837328; rs9585412; rs2390464; rs6491557; rs1972237; rs7981517; rs1998467; rs4772269; rs4772280; rs11620415; rs655862; rs2485550; rs9518012; rs2482463; rs681487; rs9585419; rs7993680; rs12586047; rs7324795; rs3783181; rs17493763; rs9518036; rs9557380; rs17196569; rs9513748; rs1283279; rs3783177; rs11617787; rs9585416; rs1577898; rs1407761; rs837329; rs9554670; rs3783173; rs7990089; rs11840109; rs7998326; rs7319383; rs6491558; rs837334; rs9518014; rs7339213; rs837286; rs1932240; rs4483714; rs7987087; rs9518032; rs9582395; rs6491556; rs9300600; rs12430531; rs9518013; rs2104868; rs1610386; rs9557430; rs2760311; rs837321; rs7991032; rs9554685; rs4772299; rs10492559; rs2783209; rs1889682; rs6491543; rs7324156; rs9582378; rs7998122; rs2057449; rs9582393; rs12430759; rs17196604; rs17491680; rs2476207; rs10508043; rs9513739; rs6491549; rs837289; rs9585415; rs13378764; rs9518029; rs4771355; rs3783176; rs10851115; rs837294; rs945882; rs958424; rs12019900; rs4772295; rs9557448; rs7339029; rs11618349; rs6491553; rs9585401; rs2760312; rs3759477; rs6491546; rs7998419; rs17196645; rs9300601; rs9518039; rs9585424; rs837285; rs2181482; rs2253446; rs9518033; rs4771358; rs12428645; rs2039678; rs3742245; rs1889683; rs12431159; rs12853977; rs6491559; rs9557383; rs7983948; rs9518015; rs9300605; rs11839348; rs2390469; rs7325252; rs7997468; rs9518041; rs9300599; rs1297356; rs17196583; rs2152880; rs2095487; rs6491548; rs2760310; rs16957441; rs9518048; rs7319215; rs7330241; rs9513757; rs1283287; rs16957276; rs9518074; rs9554677; rs9557413; rs9582387; rs4561310; rs2783223; rs4772294; rs12583054; rs9300595; rs6491545; rs837288; rs17474996; rs9518042; rs9557419; rs9557382; rs16957301; rs2184971; rs9518078; rs12429006; rs7984576; rs6650288; rs7338151; rs7335466; rs7334796; rs7318220; rs3858784; rs7338491; rs7317761; rs11842730; rs9557381; rs9582386; rs9554698; rs9585369; rs12867712; rs7998254; rs9557429; rs2390468; rs837284; rs9557446; rs9554692; rs12585450; rs9557407; rs3783180; rs7326745; rs9518019; rs7995301; rs11840872; rs9518050; rs11620125; rs12431335; rs7991498; rs7995634; rs7994935; rs837337; rs8000597; rs837287; rs2146652; rs611122; rs4772283; rs7983989; rs7983504; rs9554671; rs17569833; rs7984330; rs837342; rs7328351; rs1298921; rs7984396; rs7318347; rs9554688; rs12877004; rs4526878; rs8002362; rs3783170; rs16957309; rs16957278; rs3783183; rs9557384; rs7987388; rs9518055; rs9554668; rs7333194; rs9518061; rs499180; rs11843919; rs9585366; rs11069390; rs2783218; rs11842591; rs12428073; rs9518084; rs4772266; rs9585406; rs7330254; rs1932241; rs1283290; rs4772273; rs7998029; rs9557393; rs8001168; rs12428535; rs28537986; rs1745806; rs7998142; rs11843106; rs12860027; rs12431182; rs9582369; rs1283284; rs9585423; rs7333379; rs9585370; rs2065748; rs7335918; rs7997932; rs9585431; rs2787867; rs9554691; rs837297; rs17492220; rs9554675; rs9585361; rs9300604; rs9585442; rs7998207; rs9585452; rs9557396; rs11840082; rs4771356; rs9582379; rs1283281; rs7991210; rs4772296; rs1932239; rs9300603; rs857294; rs7989993; rs9582398; rs1124035; rs2783217; rs3215976; rs7320133; rs6491552; rs629509; rs16957348; rs9585427; rs4322518; rs11840165; rs12429061; rs17196562; rs9557436; rs3783184; rs1298506; rs2482464; rs12864917; rs837293; rs837319; rs2783229; rs8001073; rs7995595; rs7997368; rs1292970; rs9518028; rs530936; rs7993746; rs1115189; rs4771363; rs9518044; rs2184554; rs9554697; rs9518038; rs9554676; rs9582385; rs12867319; rs17254227; rs7326971; rs7991395; rs7328106; rs2057450; rs7324290; rs4772267; rs9585405; rs2255873; rs4772274; rs12428048; rs12431051; rs9513744; rs4772288; rs7982075; rs12853194; rs473180; rs9585383; rs837298; rs7986115; rs9513759; rs7329607; rs7324860; rs9554680; rs9557378; rs7999074; rs539158; rs9557443; rs3783178; rs2150886; rs1034267; rs7998648; rs9518040; rs4772286; rs12870630; rs7333679; rs1577899; rs1074602; rs9513731; rs9518064; rs7400074; rs7328528; rs7319103; rs9585417; rs1283357; rs2783216; rs569393; rs1283293; rs6650267; rs7326284; rs9557414; rs9557412; rs2783211; rs7999397; rs7996261; rs9585441; rs16957305; rs9585363; rs9585350; rs9585352; rs7326580; rs11840848; rs7994168; rs3949482; rs11069399; rs837326; rs9554689; rs16957340; rs4772264; rs1283285; rs17792266; rs12431042; rs1856217; rs9513743; rs12430705; rs7999102; rs4772279; rs17492046; rs9585450; rs2485548; rs9518004; rs837295; rs16957384; rs9557437; rs12560555; rs7981883; rs12018334; rs2095025; rs7337028; rs16957280; rs9518037; rs7996460; rs1300090; rs13378881; rs7997732; rs9585357; rs7331834; rs7328501; rs1624962; rs4622375; rs12429310; rs7318324; rs9585410; rs9585371; rs9557391; rs7329820; rs8001215; rs16957391; rs2390466; rs2152274; rs9582392; rs35055557; rs958439; rs7319707; rs4771362; rs12430993; rs9518063; rs4771365; rs9585368; rs9585377; rs9554699; rs11839111; rs7984104; rs1283288; rs11839052; rs4772298; rs4772285; rs7336442; rs16957255; rs7319434; rs7991180; rs4772276; rs4772290; rs7993067; rs2057448; rs11842030; rs7339196; rs9518054; rs10775030; rs9557386; rs9585432; rs9557389; rs4771361; rs9300590; rs9518006; rs4625587; rs4424775; rs7330289; rs9585364; rs7336947; rs837336; rs9518080; rs12874460; rs9300606; rs9585440; rs1745800; rs9582388; rs9585381; rs7139771; rs11840916; rs837291; rs9585386; rs1745807; rs7337835; rs9585407; rs1283282; rs1298922; rs7997975; rs9513742; rs4772281; rs1283286; rs9585411; rs9585408; rs12428913; rs2150882; rs837296; rs9557385; rs8002537; rs4771364; rs837317; rs7329721; rs17612953; rs2057446; rs9554669; rs9557445; rs9518059; rs9518062; rs4772272; rs837333; rs8000615; rs9557421; rs9513745; rs3783175; rs2783227; rs11069400; rs7321438; rs9518023; rs7993241; rs3742251; rs3742250; rs35719359; rs11539554; rs41281120; rs3899076; rs15466; rs41281122; rs41281124; rs35218503; rs1577900; rs35706510; rs9582371; rs28526486; rs12021107; rs35803542; rs9585437; rs9585443; rs5806157; rs7993228; rs34466523; rs35122716; rs10661172; rs9557433; rs2390435; rs11355553; rs34328488; rs12869110; rs28661086; rs9557410; rs9585397; rs11459500; rs11616574; rs9557424; rs35156913; rs5003101; rs1953696; rs35796452; rs10524763; rs7320936; rs35093653; rs12864519; rs9513756; rs12862978; rs9554679; rs9585360; rs10604327; rs35369764; rs35125499; rs9585446; rs34738581; rs9518075; rs837320; rs9554678; rs34906541; rs9554700; rs28688090; rs35416560; rs34061785; rs7334376; rs11620549; rs9513760; rs9518005; rs35596876; rs10689053; rs9585392; rs28791556; rs7489822; rs28718206; rs33937642; rs35291158; rs5806153; rs9513752; rs3058405; rs9585403; rs34460515; rs10678691; rs2184553; rs12863689; rs9518030; rs9585359; rs35584409; rs11362141; rs11349569; rs10547695; rs11289175; rs11330623; rs35332994; rs12017175; rs9585422; rs3842309; rs28841347; rs9518066; rs11332898; rs34453394; rs34801958; rs10638400; rs9585384; rs16957232; rs12877483; rs12877100; rs9585345; rs9585413; rs12866574; rs28687769; rs11360946; rs34224240; rs12020635; rs4356338; rs11324666; rs9557416; rs9585365; rs9582394; rs4142254; rs11620277; rs9513737; rs9557402; rs12870346; rs34690408; rs35753173; rs35302187; rs1299717; rs7322773; rs35260191; rs2390430; rs3034652; rs10528668; rs9585380; rs35322811; rs34997795; rs12866977; rs7335300; rs35100060; rs9585391; rs9582381; rs9518070; rs12865697; rs10467267; rs35971629; rs1575426; rs9513750; rs11427645; rs34719542; rs9582376; rs35891374; rs35316615; rs3930954; rs5806158; rs2095687; rs9634520; rs35377395; rs12872748; rs10710806; rs9518001; rs35434538; rs4772289; rs11298759; rs12868924; rs9585409; rs9518079; rs7326540; rs33945207; rs35503587; rs34304223; rs9585426; rs35322720; rs28687796; rs35779718; rs4301891; rs9585428; rs35199463; rs34015838; rs34236601; rs11838790; rs35495647; rs7324843; rs476423; rs9513730; rs9585378; rs9585389; rs9518043; rs10523177; rs12867888; rs35668106; rs28513438; rs36067066; rs34450564; rs3759478; rs35025633; rs9582373; rs35916377; rs11469076; rs34884605; rs34750393; rs12583455; rs34318074; rs9557442; rs34853750; rs10659778; rs950464; rs35895984; rs7322344; rs1283283; rs9585347; rs2760309; rs3034687; rs9557447; rs9518051; rs35433903; rs35795158; rs13378999; rs35362032; rs11269288; rs11295976; rs12877028; rs9513755; rs9518056; rs12585094; rs9585356; rs9557406; rs35058674; rs1407762; rs9518076; rs35145273; rs9557450; rs3034643; rs35054945; rs13378781; rs12100366; rs34277733; rs35338370; rs34532636; rs35233154; rs28479616; rs12864511; rs4772275; rs35523660; rs5806149; rs9585362; rs34978050; rs10129081; rs35763665; rs9557411; rs12864647; rs7991968; rs837330; rs11370189; rs9582370; rs35258256; rs34833232; rs36061462; rs9585414; rs35589266; rs34337277; rs35284370; rs7991510; rs7316948; rs35792322; rs4594108; rs34902611; rs34860703; rs2255870; rs35693167; rs34598548; rs35822001; rs35097485; rs9513734; rs34500107; rs7982816; rs12855571; rs34459939; rs36103425; rs9557405; rs12876330; rs34819598; rs34101703; rs5806150; rs5806160; rs10635557; rs35815231; rs12560943; rs7327479; rs2011329; rs16957249; rs11308030; rs36103827; rs12864651; rs7989113; rs10543745; rs28627700; rs36094195; rs34584543; rs9518083; rs34493131; rs2390431; rs3837564; rs16957258; rs4772301; rs36018621; rs9585390; rs17675144; rs35207720; rs9518071; rs35189840; rs7320549; rs35006674; rs11285694; rs12100195; rs11069391; rs28408802; rs34279630; rs34678286; rs9557417; rs34915815; rs11427230; rs34994367; rs9585373; rs2485547; rs9554694; rs11429370; rs2068451; rs34768722; rs36102222; rs12867207; rs28538960; rs36097264; rs12431041; rs16957362; rs2760316; rs9557400; rs35771657; rs11434240; rs4433673; rs3840814; rs12560571; rs16957245; rs12870926; rs36122017; rs2150884; rs9585451; rs7336260; rs12865897; rs7327523; rs34774210; rs11301747; rs35109451; rs12017512; rs34711695; rs9585399; rs34008829; rs11445363; rs10707237; rs9585388; rs7335221; rs36043786; rs9582372; rs34275910; rs9585379; rs35709393; rs12865702; rs9518065; rs670267; rs10628487; rs5806159; rs5806163; rs4261386; rs36007149; rs10467266; rs35705573; rs35809308; rs12874223; rs34917017; rs36006722; rs9300593; rs36065725; rs34765739; rs4772287; rs34256704; rs34724712; rs3742246; rs34499580; rs12869896; rs9518052; rs9557409; rs35341211; rs11840220; rs11290977; rs12864307; rs34887615; rs9585429; rs35356122; rs34276767; rs837331; rs34877951; rs35353266; rs11418617; rs7318831; rs35418436; rs9513754; rs35324283; rs35903696; rs10532627; rs11341639; rs35323808; rs13313342; rs865665; rs33975886; rs9300587; rs7338869; rs7325806; rs12864297; rs35559113; rs837340; rs10664308; rs3059677; rs9585420; rs35907275; rs9585382; rs12864837; rs10668689; rs7336935; rs9518008; rs12873170; rs1407763; rs3058594; rs36073901; rs35971474; rs10601032; rs6145198; rs9557404; rs9585394; rs34909389; rs36098330; rs34204823; rs11415038; rs34092855; rs837338; rs35401040; rs4001007; rs3825507; rs9557392; rs34528219; rs9557395; rs10606930; rs36102435; rs1974268; rs34516203; rs28607660; rs5806148; rs9582380; rs34622804; rs9582389; rs10591009; rs9518045; rs28650871; rs8181885; rs34407991; rs34944334; rs12869250; rs35077778; rs9557441; rs36055642; rs35750831; rs9557401; rs12864303; rs3088068; rs2390433; rs35996077; rs9513747; rs35686595; rs36112331; rs2390432; rs9518072; rs9518057; rs34301097; rs9557440; rs9585433; rs9518069; rs9585439; rs9554695; rs35132430; rs9585374; rs1576749; rs4772282; rs34026332; rs9554666; rs12100122; rs35584361; rs2484361; rs11439835; rs35091131; rs10688336; rs9554690; rs35539537; rs9557427; rs34433157; rs35959916; rs35612172; rs10540542; rs7990651; rs13378894; rs34214400; rs9554696; rs16957263; rs1890317; rs11459166; rs35462522; rs28735769; rs11308074; rs5806162; rs4592517; rs34812833; rs35303505; rs5806155; rs12875272; rs3837563; rs9557431; rs35563553; rs9554673; rs9582375; rs9518087; rs34268384; rs10540137; rs34731560; rs9300594; rs9557444; rs2208991; rs9585421; rs34061633; rs9557420; rs2105131; rs9557438; rs34456372; rs10613480; rs12865092; rs10628557; rs35565115; rs8181802; rs9557422; rs34079344; rs35217402; rs16957227; rs12875886; rs35822727; rs34078284; rs585662; rs36028025; rs36087144; rs7326430; rs35058442; rs34062773; rs9557379; rs10681816; rs7330143; rs35362938; rs12855843; rs2275308; rs11069392; rs34688976; rs9518058; rs12864683; rs9585398; rs7338308; rs11460805; rs9557418; rs34111533; rs28609665; rs11415881; rs28498276; rs34099057; rs34382982; rs28565916; rs10714550; rs3034651; rs10559269; rs3742248; rs34099689; rs33939903; rs35195082; rs34411352; rs7490699; rs837341; rs34041195; rs35480161; rs9585445; rs2485549; rs34291904; rs837327; rs9518067; rs837339; rs6491550; rs9585418; rs35712396; rs1885857; rs35502067; rs12866571; rs34448856; rs3058409; rs521273; rs34304013; rs28689742; rs35328550; rs9585351; rs9585349; rs4630394; rs35363090; rs10535490; rs2150885; rs10657744; rs7997277; rs34601214; rs11357539; rs9518085; rs35040953; rs2390434; rs9585404; rs28712549; rs35970742; rs35359284; rs35700826; rs9300588; rs9554693; rs9585425; rs9557428; rs7324491; rs12867611; rs11439153; rs10579468; rs3034654; rs12856604; rs12854911; rs34245334; rs11397353; rs12561151; rs9582396; rs9518073; rs8181884; rs9582400; rs28678447; rs9582377; rs9585358; rs9518068; rs35524627; rs9634521; rs35541111; rs11329867; rs9557449; rs34756197; rs9557435; rs9585438; rs28584582; rs13378193; rs9557394; rs12430630; rs35499079; rs9518046; rs7324595; rs34512005; rs7992830; rs35997465; rs4771354; rs36013684; rs11459852; rs35796024; rs3840000; rs35836219; rs5806161; rs9557434; rs36018558; rs34528026; rs10709727; rs9513733; rs2181483; rs34886548; rs35481117; rs35861672; rs9585393; rs7337677; rs34610298; rs9554674; rs35505501; rs28396410; rs34752772; rs35930661; rs5806151; rs12561161; rs34909719; rs4083752; rs11326412; rs2105130; rs28488250; rs9585400; rs34567478; rs35640811; rs28750247; rs9554687; rs7336287; rs12869263; rs9557390; rs9557403; rs28647513; rs8181887; rs34223246; rs34394682; rs1283291; rs12875978; rs8001596; rs7984018; rs10545091; rs9585354; rs12861615; rs11319347; rs7998878; rs11838791; rs34185685; rs2482462; rs11377141; rs12871481; rs35429295; rs8002297; rs12872169; rs35816963; rs2390467; rs3034650; rs34300502; rs11462726; rs35931512; rs9518018; rs35445114; rs28705975; rs10685524; rs9518086; rs34336952; rs11450784; rs34279341; rs41281118; rs11333141; rs10523739; rs34997541; rs11350199; rs11439395; rs7324988; rs12016978; rs9557439; rs3034690; rs5806156; rs11315386; rs9585444; rs35520065; rs34884178; rs9518002; rs10454528; rs35027327; rs9557423; rs34109551; rs34133206; rs35437792; rs34689498; rs36065592; rs3742252; rs12873320; rs12873358; rs3742249; rs9513729; rs35321520; rs12100185; rs16957483; rs1885858; rs2760307; rs28706364; rs35235268; rs35998503; rs4772303; rs7140059; rs7335993; rs7984886; rs837301; rs837343; rs837344; rs9513721; rs9585454

# Metabolic_Enzyme_8_General_References:
2740237; 3460076; 8434582; 3555348; 10502773; 10101253; 12559849; 10329019

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5248

# Metabolic_Enzyme_9_Name:
Pyruvate carboxylase, mitochondrial precursor

# Metabolic_Enzyme_9_Synonyms:
Pyruvic carboxylase; PCB

# Metabolic_Enzyme_9_Gene_Name:
PC

# Metabolic_Enzyme_9_Protein_Sequence:
>Pyruvate carboxylase, mitochondrial precursor
MLKFRTVHGGLRLLGIRRTSTAPAASPNVRRLEYKPIKKVMVANRGEIAIRVFRACTELG
IRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDAVHPGYGF
LSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEA
HEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIE
KPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTSDSVKLAK
QVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDL
GLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISP
HYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIAFLQNVLNNQQFLAGTVDTQF
IDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPPPAG
FRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSK
LFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVF
KFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSL
QYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGV
AAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFDYSEYWEG
ARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQM
LGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFP
EPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHF
KDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFEL
NGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVL
SAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE

# Metabolic_Enzyme_9_Number_of_Residues:
1178

# Metabolic_Enzyme_9_Molecular_Weight:
129635

# Metabolic_Enzyme_9_Theoretical_pI:
6.83

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  ligase activity, forming carbon-carbon bonds
Function:  pyruvate carboxylase activity
Function:  ligase activity
Function:  vitamin binding
Function:  biotin binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
 ||
>>>
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  gluconeogenesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate

# Metabolic_Enzyme_9_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00252  Alanine and aspartate metabolism;
 map00620  Pyruvate metabolism

# Metabolic_Enzyme_9_Reaction:
ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF02785:Biotin_carb_C;
PF00364:Biotin_lipoyl;
PF00289:CPSase_L_chain;
PF02786:CPSase_L_D2;
PF00682:HMGL-like;
PF02436:PYC_OADA

# Metabolic_Enzyme_9_Signals:
1-21

# Metabolic_Enzyme_9_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 6.4.1.1

# Metabolic_Enzyme_9_GenBank_ID_Protein:
458236

# Metabolic_Enzyme_9_SwissProt_ID:
PYC_HUMAN (P11498)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
PC

# Metabolic_Enzyme_9_Geneatlas_id:
PC

# Metabolic_Enzyme_9_hgnc_id:
HGNC:8636

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_9_Gene_Sequence:
>3537 bp
ATGCTGAAGTTCCGAACAGTCCATGGGGGCCTGAGGCTCCTGGGAATCCGCCGAACCTCC
ACCGCCCCCGCTGCCTCCCCAAATGTCCGGCGCCTGGAGTATAAGCCCATCAAGAAAGTC
ATGGTGGCCAACAGAGGTGAGATTGCCATCCGTGTGTTCCGGGCCTGCACGGAGCTGGGC
ATCCGCACCGTAGCCATCTACTCTGAGCAGGACACGGGCCAGATGCACCGGCAGAAAGCA
GATGAAGCCTATCTCATCGGCCGCGGCCTGGCCCCCGTGCAGGCCTACCTGCACATCCCA
GACATCATCAAGGTGGCCAAGGAGAACAACGTAGATGCAGTGCACCCTGGCTACGGGTTC
CTCTCTGAGCGAGCGGACTTCGCCCAGGCCTGCCAGGATGCAGGGGTCCGGTTTATTGGG
CCAAGCCCAGAAGTGGTCCGCAAGATGGGAGACAAGGTGGAGGCCCGGGCCATCGCCATT
GCTGCGGGTGTTCCCGTTGTCCCTGGCACAGATGCCCCCATCACGTCCCTGCATGAGGCC
CACGAGTTCTCCAACACCTACGGCTTCCCCATCATCTTCAAGGCGGCCTATGGGGGTGGA
GGGCGTGGCATGAGGGTGGTGCACAGCTACGAGGAGCTGGAGGAGAATTACACCCGGGCC
TACTCAGAGGCTCTGGCCGCCTTTGGGAATGGGGCGCTGTTTGTGGAGAAGTTCATCGAG
AAGCCACGGCACATCGAGGTGCAGATCTTGGGGGACCAGTATGGGAACATCCTGCACCTG
TACGAGCGAGACTGCTCCATCCAGCGGCGGCACCAGAAGGTGGTCGAGATTGCCCCCGCC
GCCCACCTGGACCCGCAGCTTCGGACTCGGCTCACCAGCGACTCTGTGAAACTCGCTAAA
CAGGTGGGCTACGAGAACGCAGGCACCGTGGAGTTCCTGGTGGACAGGCACGGCAAGCAC
TACTTCATCGAGGTCAACTCCCGCCTGCAGGTGGAGCACACGGTCACAGAGGAGATCACC
GACGTAGACCTGGTCCATGCTCAGATCCACGTGGCTGAGGGCAGGAGCCTACCCGACCTG
GGCCTGCGGCAGGAGAACATCCGCATCAACGGGTGTGCCATCCAGTGCCGGGTCACCACC
GAGGACCCCGCGCGCAGCTTCCAGCCGGACACCGGCCGCATTGAGGTGTTCCGGAGCGGA
GAGGGCATGGGCATCCGCCTGGATAATGCTTCCGCCTTCCAAGGAGCCGTCATCTCGCCC
CACTACGACTCCCTGCTGGTCAAAGTCATTGCCCACGGCAAAGACCACCCCACGGCCGCC
ACCAAGATGAGCAGGGCCCTTGCGGAGTTCCGCGTCCGAGGTGTGAAGACCAACATCGCC
TTCCTGCAGAATGTGCTCAACAACCAGCAGTTCCTGGCAGGCACTGTGGACACCCAGTTC
ATCGACGAGAACCCAGAGCTGTTCCAGCTGCGGCCTGCACAGAACCGGGCCCAAAAGCTG
TTGCACTACCTCGGCCATGTCATGGTAAACGGTCCAACCACCCCGATTCCCGTCAAGGCC
AGCCCCAGCCCCACGGACCCCGTTGTCCCTGCAGTGCCCATAGGCCCGCCCCCGGCTGGT
TTCAGAGACATCCTGCTGCGAGAGGGGCCTGAGGGCTTTGCTCGAGCTGTGCGGAACCAC
CCGGGGCTGCTGCTGATGGACACGACCTTCAGGGACGCCCACCAGTCACTGCTGGCCACT
CGTGTGCGCACCCACGATCTCAAAAAGATCGCCCCCTATGTTGCCCACAACTTCAGCAAG
CTCTTCAGCATGGAGAACTGGGGAGGAGCCACGTTTGACGTCGCCATGCGCTTCCTGTAT
GAGTGCCCCTGGCGGCGGCTGCAGGAGCTCCGGGAGCTCATCCCCAACATCCCTTTCCAG
ATGCTGCTGCGGGGGGCCAATGCTGTGGGCTACACCAACTACCCAGACAACGTGGTCTTC
AAGTTCTGTGAAGTGGCCAAAGAGAATGGCATGGATGTCTTCCGTGTGTTTGACTCCCTC
AACTACTTGCCCAACATGCTGCTGGGCATGGAGGCGGCAGGAAGTGCCGGAGGCGTGGTG
GAGGCTGCCATCTCATACACGGGCGACGTGGCCGACCCCAGCCGCACCAAGTACTCACTG
CAGTACTACATGGGCTTGGCCGAAGAGCTGGTGCGAGCTGGCACCCACATCCTGTGCATC
AAGGACATGGCCGGGCTGCTGAAGCCCACGGCCTGCACCATGCTGGTCAGCTCCCTCCGG
GACCGCTTCCCCGACCTCCCACTGCACATCCACACCCACGACACGTCAGGGGCAGGCGTG
GCAGCCATGCTGGCCTGTGCCCAGGCTGGAGCTGATGTGGTGGATGTGGCAGCTGATTCC
ATGTCTGGGATGACTTCACAGCCCAGCATGGGGGCCCTGGTGGCCTGTACCAGAGGGACT
CCCCTGGACACAGAGGTGCCCATGGAGCGCGTGTTTGACTACAGTGAGTACTGGGAGGGG
GCTCGGGGACTGTACGCGGCCTTCGACTGCACGGCCACCATGAAGTCTGGCAACTCGGAC
GTGTATGAAAATGAGATCCCAGGGGGCCAGTACACCAACCTGCACTTCCAGGCCCACAGC
ATGGGGCTTGGCTCCAAGTTCAAGGAGGTCAAGAAGGCCTATGTGGAGGCCAACCAGATG
CTGGGCGATCTCATCAAGGTGACGCCCTCCTCCAAGATCGTGGGGGACCTGGCCCAGTTT
ATGGTGCAGAATGGATTGAGCCGGGCAGAGGCCGAAGCTCAGGCGGAAGAGCTGTCCTTT
CCCCGCTCCGTGGTGGAGTTCCTGCAGGGCTACATCGGTGTCCCCCATGGGGGGTTCCCC
GAACCCTTTCGCTCTAAGGTACTGAAGGACCTGCCAAGGGTGGAGGGGCGGCCTGGAGCC
TCCCTCCCTCCCCTGGATCTGCAGGCACTGGAGAAGGAGCTGGTAGACCGGCATGGGGAG
GAGGTGACGCCGGAAGATGTGCTCTCAGCAGCTATGTACCCCGATGTGTTTGCCCACTTC
AAGGACTTCACTGCCACCTTTGGCCCCCTGGATAGCCTGAATACTCGCCTCTTCCTGCAG
GGACCCAAGATCGCAGAGGAGTTTGAGGTGGAGCTGGAGCGGGGCAAGACGCTGCACATC
AAAGCCCTGGCCGTGAGCGACCTGAACCGGGCCGGCCAGAGGCAGGTCTTCTTTGAGCTC
AATGGGCAGCTGCGGTCCATCTTGGTCAAGGACACCCAGGCCATGAAGGAGATGCACTTC
CACCCCAAGGCCCTAAAGGACGTGAAGGGCCAGATCGGGGCGCCCATGCCTGGGAAGGTG
ATAGACATCAAAGTGGTGGCAGGGGCCAAGGTGGCCAAGGGCCAGCCCCTGTGTGTGCTC
AGTGCCATGAAGATGGAGACTGTGGTGACCTCACCCATGGAGGGTACTGTCCGCAAGGTT
CATGTGACCAAGGACATGACACTGGAAGGTGACGACCTCATCCTGGAGATCGAGTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
U04641

# Metabolic_Enzyme_9_Chromosome_Location:
Not Available

# Metabolic_Enzyme_9_Locus:
Not Available

# Metabolic_Enzyme_9_SNPs:
Not Available

# Metabolic_Enzyme_9_General_References:
7918683; 8048912; 3555348; 6548474; 9585612; 9585002

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
7434

# Metabolic_Enzyme_10_Name:
Caspase-3 precursor

# Metabolic_Enzyme_10_Synonyms:
CASP-3; Apopain; Cysteine protease CPP32; Yama protein; CPP-32; SREBP cleavage activity 1; SCA-1[Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]

# Metabolic_Enzyme_10_Gene_Name:
CASP3

# Metabolic_Enzyme_10_Protein_Sequence:
>Caspase3 precursor
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

# Metabolic_Enzyme_10_Number_of_Residues:
277

# Metabolic_Enzyme_10_Molecular_Weight:
31608

# Metabolic_Enzyme_10_Theoretical_pI:
6.51

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  cysteine-type endopeptidase activity
Function:  caspase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Not Available

# Metabolic_Enzyme_10_Specific_Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin

# Metabolic_Enzyme_10_Pathway:
Not Available

# Metabolic_Enzyme_10_Reaction:
Not Available

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00656:Peptidase_C14

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 3.4.22.56

# Metabolic_Enzyme_10_GenBank_ID_Protein:
561666

# Metabolic_Enzyme_10_SwissProt_ID:
CASP3_HUMAN (P42574)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
CASP3

# Metabolic_Enzyme_10_Geneatlas_id:
CASP3

# Metabolic_Enzyme_10_hgnc_id:
HGNC:1504

# Metabolic_Enzyme_10_PDB_ID:
1CP3

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_10_Gene_Sequence:
>834 bp
ATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATC
ATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGAT
TATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGA
ATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAAC
TTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATG
CGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGC
CATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACA
AACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATT
CAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGAT
GACATGGCGTGTCATAAAATACCAGTGGATGCCGACTTCTTGTATGCATACTCCACAGCA
CCTGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGT
GCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAAC
CGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAA
CAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
U13737

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_10_Locus:
4q34

# Metabolic_Enzyme_10_SNPs:
rs35578277; rs1049210; rs35566035; rs1049253; rs2720378; rs3087455; rs6948; rs4647640; rs4647610; rs4647617; rs4647642; rs4647634; rs4647611; rs4647620; rs1049216; rs4647641; rs4647618; rs4647609; rs4647694; rs8549; rs4647698; rs4647614; rs4647621; rs4647622; rs4647616; rs4647633; rs4647643; rs4647630; rs34184817; rs4647647; rs35422505; rs4647624; rs4647626; rs4647696; rs4647606; rs4647631; rs4647646; rs4647607; rs4647625; rs34022730; rs35439719; rs2720377; rs4647632; rs4647628; rs2310103; rs34309992; rs4647629; rs4647644; rs4647636; rs2019978; rs2705891; rs1830254; rs2720376; rs2696056; rs4241793; rs4647667; rs4647688; rs4647663; rs1405942; rs4647652; rs1405938; rs4647662; rs2705901; rs1405944; rs4647671; rs4647665; rs2696057; rs4647693; rs4647672; rs2705897; rs4647669; rs4647673; rs4647692; rs4647674; rs4647666; rs4647686; rs4647683; rs4647690; rs4647657; rs4987118; rs4647679; rs4647670; rs4987119; rs4647658; rs4647684; rs4647675; rs4647650; rs34319440; rs4647685; rs2696048; rs4647651; rs4647676; rs4647687; rs4647655; rs13128316; rs13435139; rs4647704; rs4647700; rs12646257; rs4647701; rs4647623; rs4647635; rs10028033; rs12641602; rs13101834; rs11380373; rs4647695; rs34119644; rs2705892; rs34858791; rs35063555; rs4647699; rs4647639; rs34095700; rs4647619; rs13102911; rs4647645; rs4647612; rs13101835; rs4647637; rs4647638; rs2705893; rs4647649; rs2696060; rs10028034; rs4647697; rs4647613; rs35978407; rs4647608; rs4647615; rs28418774; rs4647648; rs1802667; rs34568867; rs7442206; rs4647682; rs4647656; rs4647681; rs4647668; rs4647677; rs4647678; rs4647691; rs35261594; rs4647689; rs4647653; rs35966919; rs34740772; rs4647659; rs41314884; rs9997231; rs3215361; rs4647661; rs4647654; rs10014306; rs10660141; rs4647664; rs4647660; rs4647680; rs10034836; rs35094553; rs9715122; rs4647705; rs34083547; rs9715863; rs4647702; rs4647703; rs11930666; rs12108497; rs12507711; rs13108061; rs13435890; rs1405937; rs2696058; rs2696059; rs2705881; rs2705882; rs2705900; rs2720388; rs2720389; rs34605630; rs4647600; rs4647602; rs4647603; rs4647605; rs4861629; rs4862396; rs4862399; rs7673753; rs7674164; rs7687648; rs9685847

# Metabolic_Enzyme_10_General_References:
7983002; 7774019; 7596430; 8673606; 9045680; 10821855; 8755496; 8696339

# Metabolic_Enzyme_10_References:
15956583; 15971673; 16254845; 16374167

# Metabolic_Enzyme_11_ID:
7792

# Metabolic_Enzyme_11_Name:
Mitogen-activated protein kinase 14

# Metabolic_Enzyme_11_Synonyms:
Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAX-interacting protein 2; MAP kinase MXI2; SAPK2A

# Metabolic_Enzyme_11_Gene_Name:
MAPK14

# Metabolic_Enzyme_11_Protein_Sequence:
>Mitogenactivated protein kinase 14
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES


# Metabolic_Enzyme_11_Number_of_Residues:
360

# Metabolic_Enzyme_11_Molecular_Weight:
41294

# Metabolic_Enzyme_11_Theoretical_pI:
5.58

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Not Available

# Metabolic_Enzyme_11_Specific_Function:
Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis

# Metabolic_Enzyme_11_Pathway:
Not Available

# Metabolic_Enzyme_11_Reaction:
Not Available

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00069:Pkinase

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.7.11.24

# Metabolic_Enzyme_11_GenBank_ID_Protein:
603917

# Metabolic_Enzyme_11_SwissProt_ID:
MK14_HUMAN (Q16539)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
MAPK14

# Metabolic_Enzyme_11_Geneatlas_id:
MAPK14

# Metabolic_Enzyme_11_hgnc_id:
HGNC:6876

# Metabolic_Enzyme_11_PDB_ID:
1W84

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Cytoplasm. Nucleus (By similarity)

# Metabolic_Enzyme_11_Gene_Sequence:
>1083 bp
ATGTCTCAGGAGAGGCCCACGTTCTACCGGCAGGAGCTGAACAAGACAATCTGGGAGGTG
CCCGAGCGTTACCAGAACCTGTCTCCAGTGGGCTCTGGCGCCTATGGCTCTGTGTGTGCT
GCTTTTGACACAAAAACGGGGTTACGTGTGGCAGTGAAGAAGCTCTCCAGACCATTTCAG
TCCATCATTCATGCGAAAAGAACCTACAGAGAACTGCGGTTACTTAAACATATGAAACAT
GAAAATGTGATTGGTCTGTTGGACGTTTTTACACCTGCAAGGTCTCTGGAGGAATTCAAT
GATGTGTATCTGGTGACCCATCTCATGGGGGCAGATCTGAACAACATTGTGAAATGTCAG
AAGCTTACAGATGACCATGTTCAGTTCCTTATCTACCAAATTCTCCGAGGTCTAAAGTAT
ATACATTCAGCTGACATAATTCACAGGGACCTAAAACCTAGTAATCTAGCTGTGAATGAA
GACTGTGAGCTGAAGATTCTGGATTTTGGACTGGCTCGGCACACAGATGATGAAATGACA
GGCTACGTGGCCACTAGGTGGTACAGGGCTCCTGAGATCATGCTGAACTGGATGCATTAC
AACCAGACAGTTGATATTTGGTCAGTGGGATGCATAATGGCCGAGCTGTTGACTGGAAGA
ACATTGTTTCCTGGTACAGACCATATTAACCAGCTTCAGCAGATTATGCGTCTGACAGGA
ACACCCCCCGCTTATCTCATTAACAGGATGCCAAGCCATGAGGCAAGAAACTATATTCAG
TCTTTGACTCAGATGCCGAAGATGAACTTTGCGAATGTATTTATTGGTGCCAATCCCCTG
GCTGTCGACTTGCTGGAGAAGATGCTTGTATTGGACTCAGATAAGAGAATTACAGCGGCC
CAAGCCCTTGCACATGCCTACTTTGCTCAGTACCACGATCCTGATGATGAACCAGTGGCC
GATCCTTATGATCAGTCCTTTGAAAGCAGGGACCTCCTTATAGATGAGTGGAAAAGCCTG
ACCTATGATGAAGTCATCAGCTTTGTGCCACCACCCCTTGACCAAGAAGAGATGGAGTCC
TGA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
L35263

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_11_Locus:
6p21.3-p21.2

# Metabolic_Enzyme_11_SNPs:
Not Available

# Metabolic_Enzyme_11_General_References:
7997261; 7696354; 7479834; 10727080; 11866441; 14574404; 12665801; 7923354; 7493921; 10943842; 10838079; 8910361; 9095200; 9753691

# Metabolic_Enzyme_11_References:
15979553

# Macromolecular_Interacting_Partner_1_ID:
7556

# Macromolecular_Interacting_Partner_1_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_1_Signals:
1-18

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_1_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_1_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_1_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_1_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_1_References:
16410837; 16602722; 17023148

# Macromolecular_Interacting_Partner_2_ID:
5331

# Macromolecular_Interacting_Partner_2_Name:
Alkaline phosphatase, placental-like precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Alkaline phosphatase Nagao isozyme; Germ-cell alkaline phosphatase; GCAP; PLAP-like; ALP-1

# Macromolecular_Interacting_Partner_2_Gene_Name:
ALPPL2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Alkaline phosphatase, placentallike precursor
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLG
DGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLC
GVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDY
SQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRD
STLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERA
GQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL
KDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHV
MAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
532

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
57378

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.31

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_2_Specific_Function:
A phosphate monoester + H(2)O = an alcohol + phosphate

# Macromolecular_Interacting_Partner_2_Pathway:
map00361  gamma-Hexachlorocyclohexane degradation;
 map00790  Folate biosynthesis

# Macromolecular_Interacting_Partner_2_Reaction:
A phosphate monoester + H2O = an alcohol + phosphate

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00245:Alk_phosphatase

# Macromolecular_Interacting_Partner_2_Signals:
1-19

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
EC 3.1.3.1

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
178428

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
PPBN_HUMAN (P10696)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
ALPPL2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
ALPPL2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:441

# Macromolecular_Interacting_Partner_2_PDB_ID:
1EW2

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1599 bp
ATGCAGGGGCCCTGGGTGCTGCTCCTGCTGGGCCTGAGGCTACAGCTCTCCCTGGGCATC
ATCCCAGTTGAGGAGGAGAACCCGGACTTCTGGAACCGCCAGGCAGCCGAGGCCCTGGGT
GCCGCCAAGAAGCTGCAGCCTGCACAGACAGCCGCCAAGAACCTCATCATGTTCCTGGGT
GACGGGATGGGGGTGTCTACGGTGACAGCTGCCAGGATCCTAAAAGGGCAGAAGAAGGAC
AAACTGGGGCCTGAGACCTTCCTGGCCATGGACCGCTTCCCGTACGTGGCTCTGTCCAAG
ACATACAGTGTAGACAAGCATGTGCCAGACAGTGGAGCCACAGCCACGGCCTACCTGTGC
GGGGTCAAGGGCAACTTCCAGACCATTGGCTTGAGTGCAGCCGCCCGCTTTAACCAGTGC
AACACGACACGCGGCAACGAGGTCATCTCCGTGGTGAATCGGGCCAAGAAAGCAGGAAAG
TCAGTGGGAGTGGTAACCACCACACGGGTGCAGCATGCCTCGCCAGCCGGCACCTACGCC
CACACGGTGAACCGCAACTGGTACTCGGATGCCGACGTGCCTGCCTCGGCCCGCCAGGAG
GGGTGCCAGGACATCGCCACGCAGCTCATCTCCAACATGGACATTGATGTGATCCTAGGT
GGAGGCCGAAAGTACATGTTTCCCATGGGGACCCCAGACCCTGAGTACCCAGATGACTAC
AGCCAAGGTGGGACCAGGCTGGACGGGAAGAATCTGGTGCAGGAATGGCTGGCGAAGCAC
CAGGGTGCCCGGTACGTGTGGAACCGCACTGAGCTCCTGCAGGCTTCCCTGGACCCGTCT
GTGACCCATCTCATGGGTCTCTTTGAGCCTGGAGACATGAAATACGAGATCCACCGAGAC
TCCACACTGGACCCCTCCCTGATGGAGATGACAGAGGCTGCCCTGCTCCTGCTGAGCAGG
AACCCCCGCGGCTTCTTCCTCTTCGTGGAGGGTGGTCGCATCGACCATGGTCATCATGAA
AGCAGGGCTTACCGGGCACTGACTGAGACGATCATGTTCGACGACGCCATTGAGAGGGCG
GGCCAGCTCACCAGCGAGGAGGACACGCTGAGCCTCGTCACTGCCGACCACTCCCACGTC
TTCTCCTTCGGAGGCTACCCCCTGCGAGGGAGCTCCATCTTCGGGCTGGCCCCTGGCAAG
GCCCGGGACAGGAAGGCCTACACGGTCCTCCTATACGGAAACGGTCCAGGCTATGTGCTC
AAGGACGGCGCCCGGCCGGATGTTACGGAGAGCGAGAGCGGGAGCCCCGAGTATCGGCAG
CAGTCAGCAGTGCCCCTGGACGGAGAGACCCACGCAGGCGAGGACGTGGCGGTGTTCGCG
CGCGGCCCGCAGGCGCACCTGGTTCACGGCGTGCAGGAGCAGACCTTCATAGCGCACGTC
ATGGCCTTCGCCGCCTGCCTGGAGCCCTACACCGCCTGCGACCTGGCGCCCCCCGCCGGC
ACCACCGACGCCGCGCACCCGGGGCCGTCCGTGGTCCCCGCGTTGCTTCCTCTGCTGGCA
GGGACCTTGCTGCTGCTGGGGACGGCCACTGCTCCCTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
J03252

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_2_Locus:
2q37

# Macromolecular_Interacting_Partner_2_SNPs:
rs1048983; rs1048999; rs17416141; rs2090543; rs1048997; rs1009934; rs2678519; rs2697781; rs3828248; rs3828254; rs2697767; rs3828249; rs2697768; rs1048995; rs16836187; rs3116148; rs1130334; rs41265119; rs41265117; rs3111340; rs41265115; rs1049002; rs1049001; rs3189080; rs3924351; rs1049003; rs1130348; rs1130351; rs3924352; rs3189077; rs6728119; rs2091555; rs2945420; rs2678518; rs41265113; rs3111339; rs3833560; rs2678517; rs2945421; rs41265111; rs2091556; rs3830644; rs3828251; rs3828253; rs2697769; rs11363206; rs3828250; rs3828252; rs11678251; rs1001868; rs10195918; rs13002718; rs13003189; rs13412526; rs1878691; rs2082841; rs2082842; rs2139026; rs2139027; rs2573208; rs2573209; rs2697766; rs2697790; rs2697791; rs2697792; rs2697793; rs2741321; rs2853380; rs732581; rs744873; rs744874; rs790050; rs790051

# Macromolecular_Interacting_Partner_2_General_References:
2834730; 2745460; 2297757; 2162249; 3387245

# Macromolecular_Interacting_Partner_2_References:
15907640; 16459608; 16890168; 17107008

# Macromolecular_Interacting_Partner_3_ID:
6352

# Macromolecular_Interacting_Partner_3_Name:
Atrial natriuretic peptide receptor B precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
ANP-B; ANPRB; GC-B; Guanylate cyclase B; NPR-B; Atrial natriuretic peptide B-type receptor

# Macromolecular_Interacting_Partner_3_Gene_Name:
NPR2

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Atrial natriuretic peptide receptor B precursor
MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRAL
PVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLL
TAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPH
YFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQA
QRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYRE
PPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTRED
GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW
TGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRK
LMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANT
GHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCP
RGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKI
TDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALR
SGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFG
QIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPH
SVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNF
DVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGV
HTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELR
GDVEMKGKGKMRTYWLLGERKGPPGLL

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
1047

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
117024

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.86

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  peptide receptor activity, G-protein coupled
Function:  catalytic activity
Function:  lyase activity
Function:  phosphorus-oxygen lyase activity
 ||
>>>
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  cyclic nucleotide biosynthesis
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Signal transduction mechanisms 

# Macromolecular_Interacting_Partner_3_Specific_Function:
Receptor for atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). Has guanylate cyclase activity on binding of ligand. The activation order seems to be CNP > BNP > ANP

# Macromolecular_Interacting_Partner_3_Pathway:
map00230  Purine metabolism

# Macromolecular_Interacting_Partner_3_Reaction:
GTP = 3',5'-cyclic GMP + diphosphate

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF01094:ANF_receptor;
PF00211:Guanylate_cyc;
PF00069:Pkinase

# Macromolecular_Interacting_Partner_3_Signals:
1-22

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
459-478

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
EC 4.6.1.2

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
5139790

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
ANPRB_HUMAN (P20594)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
NPR2

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
NPR2

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:7944

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>3144 bp
ATGGCGCTGCCATCACTTCTGCTGTTGGTGGCAGCCCTGGCAGGTGGGGTGCGTCCTCCC
GGGGCGCGGAACCTGACGCTGGCGGTGGTGCTGCCAGAACACAACCTGAGCTATGCCTGG
GCCTGGCCACGGGTGGGACCCGCTGTGGCACTAGCTGTGGAGGCTCTGGGCCGGGCACTG
CCCGTGGACCTGCGGTTTGTCAGCTCCGAACTGGAAGGCGCCTGCTCTGAGTACCTGGCA
CCGCTGAGCGCTGTGGACCTCAAGCTGTACCATGACCCCGACCTGCTGTTAGGTCCCGGT
TGCGTGTACCCTGCTGCCTCTGTGGCCCGCTTTGCCTCCCACTGGCGCCTTCCCCTGCTG
ACTGCGGGTGCTGTGGCCTCTGGTTTTTCGGCTAAGAATGACCATTATCGTACCCTGGTT
CGCACTGGCCCCTCTGCTCCCAAGCTGGGTGAGTTTGTGGTGACACTACACGGGCACTTC
AATTGGACTGCCCGTGCTGCCTTGCTGTACCTGGATGCTCGCACAGATGACCGGCCTCAC
TACTTCACCATCGAGGGCGTCTTTGAGGCCCTGCAGGGCAGCAACCTCAGTGTGCAGCAC
CAGGTGTATGCCCGAGAGCCAGGGGGCCCCGAGCAGGCCACCCACTTCATCCGGGCCAAC
GGGCGCATTGTGTATATCTGCGGCCCTCTGGAGATGCTGCATGAGATCCTGCTTCAGGCC
CAGAGGGAGAATCTGACCAATGGGGATTATGTCTTCTTTTACCTGGATGTCTTTGGGGAG
AGTCTCCGTGCAGGCCCCACACGTGCTACAGGCCGGCCCTGGCAGGACAATCGCACCCGG
GAACAGGCCCAGGCCCTCAGAGAGGCCTTTCAGACTGTATTGGTGATCACGTACCGAGAA
CCCCCAAATCCTGAGTATCAGGAATTCCAGAATCGTCTGCTGATAAGAGCCCGGGAAGAC
TTTGGTGTGGAGCTGGGCCCTTCCCTGATGAACCTCATCGCTGGCTGCTTCTATGATGGG
ATCCTGCTATATGCTGAAGTCCTGAATGAGACAATACAGGAAGGAGGCACCCGGGAGGAT
GGACTTCGAATTGTGGAAAAGATGCAGGGACGAAGATATCACGGTGTAACTGGGCTGGTT
GTCATGGACAAGAACAATGACCGAGAGACTGACTTTGTCCTCTGGGCCATGGGAGACCTG
GATTCTGGGGACTTTCAGCCTGCAGCCCACTACTCGGGAGCTGAGAAGCAGATTTGGTGG
ACGGGACGGCCTATTCCCTGGGTGAAGGGGGCTCCTCCCTCGGACAATCCCCCCTGTGCC
TTTGACTTGGACGACCCATCCTGTGATAAAACTCCACTTTCAACCCTGGCAATTGTGGCT
CTGGGCACAGGAATCACCTTCATCATGTTTGGTGTTTCCAGCTTCCTAATTTTCCGAAAG
CTGATGCTGGAGAAGGAGCTGGCTAGCATGTTGTGGCGTATTCGCTGGGAAGAACTGCAG
TTTGGCAACTCAGAGCGTTATCACAAAGGTGCAGGCAGTCGCCTCACACTGTCGCTGCGG
GGATCCAGTTACGGCTCGCTCATGACAGCCCATGGGAAATACCAGATCTTTGCCAACACC
GGTCACTTCAAGGGAAATGTTGTCGCCATCAAACATGTGAATAAGAAGCGCATTGAGCTG
ACCCGGCAGGTTCTGTTTGAACTCAAACATATGAGAGATGTTCAGTTCAACCATCTCACT
CGCTTCATTGGCGCCTGCATAGACCCTCCCAACATTTGCATTGTCACTGAATACTGTCCT
CGTGGGAGTTTACAGGATATTCTAGAAAATGACAGCATCAACTTGGACTGGATGTTTCGT
TATTCACTCATTAATGACCTTGTTAAGGGCATGGCCTTTCTCCACAACAGCATTATTTCA
TCGCATGGGAGTCTCAAGTCCTCCAACTGTGTGGTGGATAGTCGTTTTGTGCTCAAAATC
ACAGACTATGGCCTGGCCAGCTTCCGATCAACTGCTGAACCTGATGACAGCCATGCCCTC
TATGCCAAGAAGCTGTGGACTGCCCCAGAACTGCTCAGTGGGAACCCCTTGCCAACCACA
GGCATGCAGAAGGCTGACGTCTATAGCTTTGGGATCATCCTGCAGGAGATAGCACTTCGC
AGTGGTCCTTTCTACTTGGAGGGCCTGGACCTCAGCCCCAAAGAGATTGTCCAGAAGGTA
CGAAATGGTCAGCGGCCATATTTCCGGCCAAGCATTGACCGGTCCCAACTGAATGAAGAG
CTAGTTTTGCTGATGGAGCGATGTTGGGCTCAGGACCCAGCTGAGCGGCCAGACTTTGGA
CAGATTAAGGGCTTCATTCGGCGCTTTAACAAGGAGGGTGGCACCAGCATATTGGACAAC
CTCCTGCTGCGCATGGAACAGTATGCCAATAACTTGGAGAAGCTGGTGGAGGAACGCACA
CAGGCCTATCTGGAGGAAAAACGCAAGGCTGAAGCTCTGCTCTACCAAATCCTACCCCAT
TCAGTGGCAGAGCAGTTAAAACGGGGAGAGACTGTACAGGCTGAGGCCTTTGACAGTGTT
ACCATCTACTTCAGTGACATTGTTGGCTTCACAGCATTGTCAGCAGAGAGCACCCCCATG
CAGGTAGTGACACTTCTTAATGACCTGTATACCTGCTTTGATGCCATAATTGACAACTTT
GATGTCTACAAGGTGGAGACGATTGGGGATGCTTACATGGTGGTATCTGGCCTCCCAGGC
CGAAATGGTCAACGCCATGCACCAGAAATTGCTCGTATGGCCCTAGCATTACTAGATGCA
GTTTCTTCCTTTCGCATCCGCCACCGACCCCATGACCAGCTGAGGCTACGCATAGGGGTC
CATACTGGGCCAGTCTGTGCTGGGGTTGTTGGCCTGAAGATGCCCCGTTATTGTCTTTTT
GGAGACACAGTGAACACTGCTTCTCGAATGGAGTCTAATGGTCAAGCGCTGAAGATCCAT
GTCTCCTCTACCACCAAGGATGCCCTAGATGAGCTAGGATGCTTCCAGCTAGAGCTTCGG
GGGGATGTGGAAATGAAGGGAAAAGGAAAGATGCGAACATACTGGCTCTTAGGAGAGCGG
AAAGGACCTCCTGGACTCCTGTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AB005647

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_3_Locus:
9p21-p12

# Macromolecular_Interacting_Partner_3_SNPs:
rs2228580; rs5812; rs7043647; rs10758325; rs10814276; rs1322044; rs7034957; rs3793543; rs7021716; rs7031237; rs7864199; rs1407295; rs2236290; rs2236289; rs2890702; rs13288085; rs1078081; rs10758324; rs12347878; rs12553111; rs5816; rs28931581; rs28929479; rs3729731; rs3729730; rs28931582; rs5813; rs28764009; rs5815; rs4512468; rs5024028; rs13293624; rs28764011; rs34474231; rs28764014; rs4879927; rs10603903; rs35323702; rs12005446; rs35457827; rs12686421; rs34532812; rs28764012; rs3069788; rs11328092; rs35713408; rs35484064; rs1407296; rs28764008; rs1322043; rs35170845; rs28764010; rs35145770; rs28764013; rs34349173; rs3750438; rs3842217; rs34754193; rs10972585; rs35743544; rs10758323; rs10972591; rs12337802; rs12338156; rs12342037; rs13292880; rs13294264; rs13294295; rs13299765; rs2145923; rs2281645; rs2281646; rs3763631; rs3808864; rs3808865; rs4879928; rs4879929; rs6476491; rs7848310; rs7866903; rs7873145; rs878749; rs878750

# Macromolecular_Interacting_Partner_3_General_References:
2570358; 10082481; 10073597

# Macromolecular_Interacting_Partner_3_References:
15905112; 15992685; 16309850

# Macromolecular_Interacting_Partner_4_ID:
7936

# Macromolecular_Interacting_Partner_4_Name:
Apoptosis regulator Bcl-2

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
BCL2

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Apoptosis regulator Bcl2
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
239

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
26266

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
7.32

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of cellular physiological process
Process:  regulation of programmed cell death
Process:  regulation of apoptosis
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00452:Bcl-2;
PF02180:BH4

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
212-233

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
179367

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
BCL2_HUMAN (P10415)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
BCL2

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
BCL2

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:990

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass membrane protein. Nucleus; nuclear membrane; single- pass membrane protein. Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>720 bp
ATGGCGCACGCTGGGAGAACGGGGTACGACAACCGGGAGATAGTGATGAAGTACATCCAT
TATAAGCTGTCGCAGAGGGGCTACGAGTGGGATGCGGGAGATGTGGGCGCCGCGCCCCCG
GGGGCCGCCCCCGCACCGGGCATCTTCTCCTCCCAGCCCGGGCACACGCCCCATCCAGCC
GCATCCCGCGACCCGGTCGCCAGGACCTCGCCGCTGCAGACCCCGGCTGCCCCCGGCGCC
GCCGCGGGGCCTGCGCTCAGCCCGGTGCCACCTGTGGTCCACCTGGCCCTCCGCCAAGCC
GGCGACGACTTCTCCCGCCGCTACCGCGGCGACTTCGCCGAGATGTCCAGCCAGCTGCAC
CTGACGCCCTTCACCGCGCGGGGACGCTTTGCCACGGTGGTGGAGGAGCTCTTCAGGGAC
GGGGTGAACTGGGGGAGGATTGTGGCCTTCTTTGAGTTCGGTGGGGTCATGTGTGTGGAG
AGCGTCAACCGGGAGATGTCGCCCCTGGTGGACAACATCGCCCTGTGGATGACTGAGTAC
CTGAACCGGCACCTGCACACCTGGATCCAGGATAACGGAGGCTGGGATGCCTTTGTGGAA
CTGTACGGCCCCAGCATGCGGCCTCTGTTTGATTTCTCCTGGCTGTCTCTGAAGACTCTG
CTCAGTTTGGCCCTGGTGGGAGCTTGCATCACCCTGGGTGCCTATCTGAGCCACAAGTGA


# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
M13994

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:18

# Macromolecular_Interacting_Partner_4_Locus:
18q21.33|18q21.3

# Macromolecular_Interacting_Partner_4_SNPs:
rs1800477; rs1801018; rs1564483; rs1016860; rs4987853; rs4987861; rs4987843; rs4987852; rs3744935; rs4987864; rs4987856; rs4987854; rs4987855; rs4987846; rs4987851; rs4987858; rs4987850; rs4987859; rs4987865; rs4987845; rs4987869; rs3744937; rs4987847; rs1473418; rs4987867; rs720321; rs1383596; rs1944419; rs1531697; rs2046136; rs1545812; rs1481031; rs2332673; rs726510; rs899968; rs2062011; rs2850763; rs1381548; rs949037; rs2156192; rs2850761; rs7226979; rs1009726; rs4940576; rs2850762; rs6567334; rs2551397; rs2849377; rs2199937; rs4987792; rs11872403; rs11152377; rs4941195; rs4941183; rs2156190; rs2062010; rs8094489; rs11152375; rs12606418; rs8083946; rs726511; rs3810027; rs1542578; rs8094651; rs1462129; rs4941189; rs4941192; rs3810031; rs3943258; rs8088662; rs8096380; rs4940573; rs7228914; rs11661511; rs7240326; rs2156193; rs8086404; rs6567336; rs2849381; rs8094315; rs11876772; rs4987790; rs11152370; rs4987752; rs4940575; rs4456611; rs1893506; rs2046135; rs12457700; rs8088100; rs7242402; rs11661497; rs4940572; rs1944420; rs9955190; rs1944422; rs12454650; rs1977971; rs8089331; rs2850758; rs2046137; rs1573493; rs8084922; rs8089538; rs4987802; rs6567328; rs8095050; rs2156191; rs2849380; rs1481032; rs11875184; rs1807999; rs9807663; rs4940574; rs7230053; rs1982674; rs12457170; rs4941188; rs1344229; rs7234941; rs6567327; rs11152374; rs11152372; rs9965844; rs6567326; rs7239838; rs9962222; rs9959874; rs4940571; rs2187162; rs4987819; rs2051423; rs3810028; rs899966; rs4987739; rs6567329; rs4941185; rs4987718; rs10503079; rs8098548; rs3744933; rs3744948; rs17070798; rs4987760; rs8098848; rs4987788; rs7243201; rs4941187; rs12968517; rs4987772; rs4987722; rs4987803; rs731014; rs3744951; rs1982673; rs4987736; rs17070904; rs6567330; rs11659758; rs2850760; rs9967405; rs8099575; rs17757981; rs9630855; rs4987786; rs12454712; rs12457893; rs4987724; rs8099140; rs12970840; rs4987778; rs4987831; rs4987829; rs1026825; rs12458289; rs9972995; rs10503077; rs6567325; rs4987823; rs4987765; rs4987726; rs4987757; rs11152371; rs12605881; rs4987746; rs11875971; rs4987827; rs12961976; rs4987795; rs4987797; rs899965; rs7244617; rs1531695; rs9962656; rs12457831; rs11872329; rs4987838; rs4941184; rs2051424; rs2615200; rs7242542; rs8094630; rs7236090; rs6567324; rs7231914; rs1893806; rs4987768; rs17070959; rs1005793; rs8085707; rs17070739; rs11875686; rs17679032; rs4987721; rs4987808; rs765102; rs8097624; rs3744950; rs4987801; rs1009725; rs6567335; rs17070848; rs17685559; rs956572; rs12961672; rs11663275; rs744569; rs4987764; rs12457190; rs4941186; rs17070861; rs4941194; rs4987835; rs2170294; rs4987755; rs6567331; rs4987841; rs4987737; rs9959983; rs768058; rs7243091; rs8095077; rs4987725; rs4987733; rs17756073; rs11877475; rs8093973; rs4987839; rs4987759; rs4987783; rs960804; rs4987743; rs4987779; rs10503078; rs17757541; rs899964; rs7230970; rs4987716; rs7232625; rs9951943; rs9958550; rs8092560; rs4941190; rs12457371; rs4987828; rs3826622; rs8096471; rs8083727; rs4987821; rs2849382; rs9962051; rs17756365; rs17070913; rs8087120; rs2170295; rs4987810; rs6567332; rs899967; rs4987774; rs1381546; rs10460157; rs11873429; rs4987826; rs4987798; rs1473435; rs7242904; rs4987809; rs7242501; rs4987800; rs7232512; rs12957119; rs10164240; rs4987742; rs3948977; rs4987719; rs12458944; rs4987796; rs7231901; rs17678177; rs8099218; rs2551399; rs4987770; rs4987825; rs17070714; rs4987781; rs12962644; rs4987812; rs12963263; rs4987834; rs4987747; rs4987767; rs17758695; rs9963148; rs17841945; rs4987744; rs9959769; rs12457361; rs9946649; rs4987794; rs11152373; rs11872297; rs17070779; rs4987728; rs12963776; rs12958785; rs17686373; rs1976005; rs12457841; rs8092884; rs7240319; rs9946637; rs9961642; rs17759096; rs11877911; rs4987773; rs1944421; rs2170296; rs11877925; rs9961796; rs7230177; rs4987715; rs4987732; rs17070777; rs11874082; rs9965829; rs4987761; rs17758456; rs17062654; rs4987789; rs4987771; rs17070827; rs17758816; rs7232082; rs11661184; rs12962650; rs3842401; rs8098586; rs17678294; rs17677569; rs17070818; rs954954; rs9957149; rs1541298; rs4987717; rs9962421; rs17070841; rs4987730; rs8097918; rs8089306; rs12967026; rs7236202; rs4987750; rs17685987; rs2840358; rs4987787; rs4987780; rs17841946; rs4987723; rs7237139; rs1481030; rs12454618; rs12968867; rs9966563; rs17070877; rs17070809; rs9958905; rs6567333; rs3810030; rs4987741; rs12964150; rs9972996; rs7245234; rs1381547; rs17756248; rs4987807; rs12604822; rs17070735; rs17756266; rs4987824; rs12456572; rs2850755; rs17070943; rs4987749; rs17070946; rs17759659; rs12605858; rs4987791; rs4987815; rs9962963; rs3927911; rs8091529; rs4987822; rs8085473; rs4987731; rs17758403; rs4987745; rs4987818; rs9965425; rs4987793; rs1541295; rs4987832; rs12455492; rs4987720; rs4987817; rs2849379; rs17070750; rs4987830; rs4987873; rs2448799; rs8087606; rs4987872; rs2279115; rs41301945; rs5825508; rs2078303; rs4987849; rs17070680; rs41306972; rs34741396; rs4987866; rs34360708; rs34883036; rs1050618; rs34811186; rs4987707; rs4987868; rs4987844; rs4987862; rs34223591; rs4987842; rs4987870; rs4987848; rs4987710; rs4987860; rs34143126; rs4987706; rs3744936; rs4987863; rs4987857; rs11351478; rs35558540; rs36046351; rs34986306; rs11384331; rs12327138; rs34592237; rs34479040; rs35443488; rs35735146; rs4987738; rs35954402; rs9953797; rs11286497; rs34714510; rs34470267; rs2127872; rs34356346; rs10597397; rs7230110; rs5825509; rs4987769; rs11346802; rs35765197; rs35992365; rs28744646; rs35421280; rs7242051; rs7230703; rs3216124; rs11878084; rs3833192; rs9320014; rs34032861; rs10536242; rs28613776; rs35702853; rs35957660; rs11877270; rs36089071; rs11411155; rs34999271; rs28603232; rs8099362; rs11424742; rs34128466; rs4987740; rs36230193; rs35775563; rs34585115; rs9944895; rs4987754; rs34926393; rs35844118; rs4987753; rs4987763; rs9949240; rs4987751; rs7242531; rs11421019; rs28669125; rs28550381; rs28502762; rs28662060; rs34092929; rs28702921; rs35942763; rs35275357; rs35195646; rs2332672; rs7232179; rs11381388; rs34385891; rs34140806; rs28460613; rs2187163; rs35366804; rs28699603; rs4384687; rs35180138; rs12958555; rs4987713; rs4987805; rs35063180; rs28564323; rs9959358; rs4987837; rs596876; rs4987799; rs4987814; rs34360704; rs34927632; rs36074022; rs7232529; rs4987840; rs4987813; rs34603960; rs34737549; rs34810572; rs4987782; rs12956558; rs34724235; rs35832816; rs11396022; rs4987734; rs35916533; rs11426842; rs34422779; rs35788320; rs7243686; rs34269955; rs34821656; rs34331087; rs4987735; rs2615199; rs7245040; rs28537871; rs34628711; rs34530559; rs34280008; rs9946231; rs34246997; rs35618914; rs7504762; rs11285614; rs9955851; rs4987784; rs12454033; rs35117243; rs4987833; rs35832711; rs11876939; rs4987711; rs2085958; rs4987776; rs4987816; rs11271834; rs9807796; rs34929825; rs2849378; rs34498028; rs8094130; rs34272291; rs8089583; rs5825512; rs35786465; rs11437030; rs3810029; rs10560567; rs34392530; rs11875445; rs36010160; rs33935449; rs1870863; rs11874495; rs28566629; rs35829205; rs10604257; rs12327294; rs4987758; rs11407054; rs34122166; rs35501583; rs12454460; rs34597011; rs34215080; rs11664592; rs11330056; rs11348997; rs4987762; rs11346034; rs641060; rs35852603; rs34970907; rs7238198; rs35043985; rs10640757; rs35621103; rs34019962; rs4987820; rs11333396; rs12326606; rs11269260; rs36107927; rs34843082; rs35457535; rs12969008; rs10564352; rs4987748; rs35869219; rs1273018; rs28417258; rs17070962; rs34520768; rs34167266; rs34372247; rs34877412; rs1138828; rs12962685; rs12955832; rs28588396; rs12958518; rs33983598; rs4411604; rs2849374; rs8089784; rs1679896; rs12956104; rs35051109; rs28552905; rs3744949; rs34724758; rs7230557; rs4987811; rs34616260; rs34660120; rs34455531; rs7231840; rs4987766; rs11343409; rs11377778; rs11282101; rs11663364; rs12327297; rs12957272; rs34096346; rs12954887; rs35880134; rs8097683; rs7245041; rs11152376; rs11307145; rs11389759; rs34302549; rs35608542; rs34601248; rs35378587; rs34971240; rs7239903; rs4987727; rs34857794; rs34026129; rs36077676; rs34008827; rs11289698; rs28552745; rs35997590; rs36078664; rs10688243; rs35024611; rs35764546; rs34513836; rs34355655; rs720849; rs10718817; rs36027128; rs8092584; rs4987756; rs35555671; rs7242090; rs35771638; rs1789627; rs1271892; rs7236823; rs4987785; rs4987714; rs1462128; rs35032484; rs12605689; rs7239542; rs4941193; rs10537349; rs12970504; rs10642228; rs35689542; rs11393921; rs12962313; rs4987836; rs36095867; rs35696527; rs34059678; rs35046846; rs34022610; rs5825511; rs35369252; rs34870728; rs34960660; rs7244494; rs36099507; rs35770276; rs35956166; rs12964435; rs28562101; rs34051656; rs11271898; rs4987804; rs4987729; rs7231259; rs35818172; rs34831717; rs28464692; rs4987777; rs34298527; rs7504665; rs35161404; rs5825510; rs35593106; rs35291046; rs7230565; rs34430054; rs8098774; rs34875078; rs34683668; rs28484798; rs1531696; rs34596364; rs11399943; rs4987712; rs28431965; rs765479; rs34457708; rs36088248; rs12958359; rs2516293; rs34174534; rs35525138; rs2551400; rs35834230; rs4987705; rs4987871; rs2448798; rs2472571; rs35953169; rs34619379; rs10460159; rs11660715; rs17070659; rs17676919; rs17676949; rs17749561; rs1944423; rs2051422; rs2448800; rs2448804; rs2448805; rs2448806; rs2472572; rs2472574; rs2472576; rs2472577; rs2472578; rs2472579; rs2472581; rs2551402; rs2551404; rs2551405; rs2850764; rs698708; rs7243985; rs8086644; rs8094041; rs8099294; rs9320013; rs9945794; rs9957746; rs9989529

# Macromolecular_Interacting_Partner_4_General_References:
3523487; 1508712; 2875799; 2834197; 3285301; 1339299; 2250705; 8183370; 9395403; 8668206; 11368354; 10567572; 11463391; 12901880

# Macromolecular_Interacting_Partner_4_References:
16196285; 16867874

# Macromolecular_Interacting_Partner_5_ID:
8202

# Macromolecular_Interacting_Partner_5_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_5_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_5_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_5_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_5_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_5_Locus:
10q22

# Macromolecular_Interacting_Partner_5_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_5_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_5_References:
16153151; 16563343; 16723704

# Macromolecular_Interacting_Partner_6_ID:
8120

# Macromolecular_Interacting_Partner_6_Name:
Sodium-dependent multivitamin transporter

# Macromolecular_Interacting_Partner_6_Synonyms:
Na(+-dependent multivitamin transporter

# Macromolecular_Interacting_Partner_6_Gene_Name:
SLC5A6

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Sodiumdependent multivitamin transporter
MSVGVSTSAPLSPTSGTSVGMSTFSIMDYVVFVLLLVLSLAIGLYHACRGWGRHTVGELL
MADRKMGCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIFIPV
FYRLHLTSAYEYLELRFNKTVRVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSV
LALGIVCTVYTALGGLKAVIWTDVFQTLVMFLGQLAVIIVGSAKVGGLGRVWAVASQHGR
ISGFELDPDPFVRHTFWTLAFGGVFMMLSLYGVNQAQVQRYLSSRTEKAAVLSCYAVFPF
QQVSLCVGCLIGLVMFAYYQEYPMSIQQAQAAPDQFVLYFVMDLLKGLPGLPGLFIACLF
SGSLSTISSAFNSLATVTMEDLIRPWFPEFSEARAIMLSRGLAFGYGLLCLGMAYISSQM
GPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPPGAVVGLLAGLVMAFWIGIGSIVTSMG
FSMPPSPSNGSSFSLPTNLTVATVTTLMPLTTFSKPTGLQRFYSLSYLWYSAHNSTTVIV
VGLIVSLLTGRMRGRSLNPATIYPVLPKLLSLLPLSCQKRLHCRSYGQDHLDTGLFPEKP
RNGVLGDSRDKEAMALDGTAYQGSSSTCILQETSL

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
635

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
68703

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
8.32

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_6_Specific_Function:
Transports pantothenate, biotin and lipoate in the presence of sodium

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00474:SSF

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
24-44
68-88
101-121
143-163
176-196
199-219
256-276
297-317
336-356
396-416
428-448
456-476
528-548

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
5006439

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
SC5A6_HUMAN (Q9Y289)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SLC5A6

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SLC5A6

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:11041

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1908 bp
ATGAGTGTAGGGGTGAGCACCTCAGCCCCTCTTTCCCCAACCTCGGGCACAAGCGTGGGC
ATGTCTACCTTCTCCATCATGGACTATGTGGTGTTCGTCCTGCTGCTGGTTCTCTCTCTT
GCCATTGGGCTCTACCATGCTTGTCGTGGCTGGGGCCGGCATACTGTTGGTGAGCTGCTG
ATGGCGGACCGCAAAATGGGCTGCCTTCCGGTGGCACTGTCCCTGCTGGCCACCTTCCAG
TCAGCCGTGGCCATCCTGGGTGTGCCGTCAGAGATCTACCGATTTGGGACCCAATATTGG
TTCCTGGGCTGCTGCTACTTTCTGGGGCTGCTGATACCTGCACACATCTTCATCCCCGTT
TTCTACCGCCTGCATCTCACCAGTGCCTATGAGTACCTGGAGCTTCGATTCAATAAAACT
GTGCGAGTGTGTGGAACTGTGACCTTCATCTTTCAGATGGTGATCTACATGGGAGTTGTG
CTCTATGCTCCGTCATTGGCTCTCAATGCAGTGACTGGCTTTGATCTGTGGCTGTCCGTG
CTGGCCCTGGGCATTGTCTGTACCGTCTATACAGCTCTGGGTGGGCTGAAGGCCGTCATC
TGGACAGATGTGTTCCAGACACTGGTCATGTTCCTCGGGCAGCTGGCAGTTATCATCGTG
GGGTCAGCCAAGGTGGGCGGCTTGGGGCGTGTGTGGGCCGTGGCTTCCCAGCACGGCCGC
ATCTCTGGGTTTGAGCTGGATCCAGACCCCTTTGTGCGGCACACCTTCTGGACCTTGGCC
TTCGGGGGTGTCTTCATGATGCTCTCCTTATACGGGGTGAACCAGGCTCAGGTGCAGCGG
TACCTCAGTTCCCGCACGGAGAAGGCTGCTGTGCTCTCCTGTTATGCAGTGTTCCCCTTC
CAGCAGGTGTCCCTCTGCGTGGGCTGCCTCATTGGCCTGGTCATGTTCGCGTATTACCAG
GAGTATCCCATGAGCATTCAGCAGGCTCAGGCAGCCCCAGACCAGTTCGTCCTGTACTTT
GTGATGGATCTCCTGAAGGGCCTGCCAGGCCTGCCAGGGCTCTTCATTGCCTGCCTCTTC
AGCGGCTCTCTCAGCACTATATCCTCTGCTTTTAATTCATTGGCAACTGTTACGATGGAA
GACCTGATTCGACCTTGGTTCCCTGAGTTCTCTGAAGCCCGGGCCATCATGCTTTCCAGA
GGCCTTGCCTTTGGCTATGGGCTGCTTTGTCTAGGAATGGCCTATATTTCCTCCCAGATG
GGACCTGTGCTGCAGGCAGCAATCAGCATCTTTGGCATGGTTGGGGGACCGCTGCTGGGA
CTCTTCTGCCTTGGAATGTTCTTTCCATGTGCTAACCCTCCTGGTGCTGTTGTGGGCCTG
TTGGCTGGGCTCGTCATGGCCTTCTGGATTGGCATCGGGAGCATCGTGACCAGCATGGGC
TTCAGCATGCCACCCTCTCCCTCTAATGGGTCCAGCTTCTCCCTGCCCACCAATCTAACC
GTTGCCACTGTGACCACACTGATGCCCTTGACTACCTTCTCCAAGCCCACAGGGCTGCAG
CGGTTCTATTCCTTGTCTTACTTATGGTACAGTGCTCACAACTCCACCACAGTGATTGTG
GTGGGCCTGATTGTCAGTCTACTCACTGGGAGAATGCGAGGCCGGTCCCTGAACCCTGCA
ACCATTTACCCAGTGTTGCCAAAGCTCCTGTCCCTCCTTCCGTTGTCCTGTCAGAAGCGG
CTCCACTGCAGGAGCTACGGCCAGGACCACCTCGACACTGGCCTGTTTCCTGAGAAGCCG
AGGAATGGTGTGCTGGGGGACAGCAGAGACAAGGAGGCCATGGCCCTGGATGGCACAGCC
TATCAGGGGAGCAGCTCCACCTGCATCCTCCAGGAGACCTCCCTGTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
AF116241

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_6_Locus:
2p23

# Macromolecular_Interacting_Partner_6_SNPs:
rs1395; rs1064845; rs7081; rs1275530; rs1275528; rs6547496; rs2580759; rs1275529; rs1275522; rs1275521; rs2580761; rs1006898; rs1275525; rs1275527; rs1275526; rs1659685; rs41288805; rs12466181; rs11542419; rs1275523; rs1275524; rs4327199; rs35656364; rs2580758; rs996650; rs13424785; rs7424503; rs1275531; rs41288803; rs1985770; rs10638396; rs1275519; rs1298361; rs4309540; rs2580760; rs35824171; rs2014284; rs1008670; rs2580762; rs7420893; rs41288809; rs2735861; rs3072731; rs41288807; rs1882849; rs2735863; rs2735862; rs2580381; rs1044325; rs11126918; rs11608; rs11936; rs12465084; rs12469900; rs1275501; rs1275504; rs1275532; rs1275533; rs1275536; rs1275537; rs1275538; rs13383098; rs1659687; rs1659700; rs1659701; rs2078616; rs2289363; rs2735864; rs4617; rs4665373; rs4665374; rs4665958; rs724310; rs724311; rs7437

# Macromolecular_Interacting_Partner_6_General_References:
10329687; 10334869

# Macromolecular_Interacting_Partner_6_References:
15905112; 16749865; 17038304

End of HMDB00030

Beginning of HMDB00031
# Accession_No:
HMDB00031

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-14 16:01:17

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Androsterone

# Description:
Androsterone (ADT) is a steroid hormone with weak androgenic activity.  It is important for sex determination in the fetus and the maintenance of genitalia function.  Androsterone is a metabolite of TESTOSTERONE or ANDROSTENEDIONE with a 3-alpha-hydroxyl group and without the double bond. The 3-beta hydroxyl isomer is epiandrosterone.  Androsterone is made in the liver from the metabolism of testosterone. It was first isolated in 1931, by Adolf Friedrich Johann Butenandt and Kurt Tscherning. They distilled over 17000 liters of male urine, from which they got 50 milligrams of crystalline androsterone, which was sufficient to find that the chemical formula was very similar to estrone. -- Wikipedia

# Synonyms:
(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one; (3alpha,5alpha)-3-hydroxy-Androstan-17-one; 3-Epihydroxyetioallocholan-17-one; 3-Hydroxyandrostan-17-one; 3-alpha-Hydroxy-17-androstanone; 3-alpha-Hydroxy-5-alpha-androstan-17-one; 3-alpha-Hydroxy-5-alpha-androstane-17-one; 3-alpha-Hydroxyetioallocholan-17-one; 3-alpha-hydroxy-5alpha-Androstan-17-one; 3-hydroxy-(3-alpha,5-alpha)-Androstan-17-one; 3a-Hydroxyetioallocholan-17-one; 3alpha-Hydroxy-17-androstanone; 3alpha-Hydroxy-5alpha-androstan-17-one; 3alpha-Hydroxyetioallocholan-17-one; 5-alpha-Androstan-3-alpha-ol-17-one; 5-alpha-Androstane-3alpha-ol-17-one; 5-alpha-Androsterone; 5a-Androstan-3a-ol-17-one; 5a-Androstane-3a-ol-17-one; 5a-Androsterone; 5alpha-Androstane-3alpha-ol-17-one; 5alpha-Androsterone; Androkinine; Androstanon-3-alpha-ol-17-one; Androsterone; Androtine; Atromide ICI; cis-Androsterone

# Chemical_IUPAC_Name:
(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one

# Chemical_Formula:
C19H30O2

# Chemical_Structure:
tbl_chemical:::HMDB00031_ZOOM.png:::1192831414786180

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00031_THUMB.png:::119283141268477404

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Steroids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
ketone; secondary alcohol

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
290.22458

# Molecular_Weight_Avg:
290.44031

# Smiles_String_isomeric:
C[C@]12CC[C@H]3[C@@H](CCC4C[C@H](O)CC[C@]34C)[C@@H]1CCC2=O

# Smiles_String_canonical:
CC12CCC3C(CCC4CC(O)CCC34C)C1CCC2=O

# KEGG_Compound_ID:
C00523

# BioCyc_ID:
ANDROSTERONE

# PubChem_CID:
5879

# PubChem_SID:
7885731; 11486037; 10321647; 8145036; 11532920; 11466439; 4266383; 8153634; 3806; 148682; 11467559; 585814; 854588; 75252; 3138568; 841382

# OMIM_ID:
Not Available

# Metagene_ID:
3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY: 95; 21-HYDROXYLASE DEFICIENCY (CYP21): 235

# BiGG_ID:
35244

# Wikipedia_ID:
Androsterone

# METLIN_ID:
2797

# Ref_ID:
3802509; 6211346; 10625505; 158859; 7245287; 15946323; 15894033; 3162156; 2946134; 15954157; 16078844; 79632

# ChEBI_ID:
16032

# CAS_Registry_Number:
53-41-8

# InChI:
InChI=1/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12?,13-,14+,15+,16+,18+,19+/m1/s1

# Synthesis_Reference:
Marker, R.E. (1935) JACS 57:1755-1756

# Melting_Point:
185 oC

# Melting_Point_predicted:
118.8 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.012 mg/mL at 23 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
6.37e-03 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
3.69 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
3.71 [Predicted by ALOGPS]; 4.3 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Androsterone.pdf:::1132562191066860960

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Androsterone.mol:::1132723802359819972

# SDF_File_[Text]:
tbl_chemical:::HMDB00031.sdf:::11928314070852731

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00031.pdb:::119283141100456043

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::Androsterone_00031_CDCl3_noesy1d_1feb07.fid.zip:::117078848418381840

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050118_P00_08_IS_1DP_Assigned.png:::117078848421922730

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050118_P00_08_1S_2DHSQC_98.png:::114835597534634235

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050118_P00_08_IS_2DHSQC_98.zip:::114835597538116709

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050118_P00_08_1S_2DHSQC_98_Assigned.png:::116190061621084035

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Androsterone.gif:::1132732100343922805

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00031_peaks.txt:::1156309497626920121

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Androsterone_C.gif:::1132737661213513112

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00031_peaks.txt:::1156310689436126235

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00031.png:::116543399568370957; Medium Energy:tbl_ms:::HMDB00031.png:::1165433870595200662; High Energy:tbl_ms:::HMDB00031.png:::1165433912609133613

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane (Predicted from LogP); Cytoplasm; endoplasmic reticulum; Extracellular

# Tissue_Location:
Intestine; Most Tissues; Primarily Liver; Prostate; Testis

# deuterated:
No

# Biofluid_Location:
CSF; Urine

# Concentration_[Normal]:
Urine	0.66	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	2946134
Urine	6.69 +/- 1.65	umol/mmol_creatinine	Adult:>18_yrs_old	Female	Normal	6211346
Cerebrospinal_Fluid(CSF)	0.00016 +/- 0.000058	uM	Adult:>18_yrs_old	Male	Normal	10625505
N/A	0.041 +/-0.017	uM	Adult:>18_yrs_old	Both	Normal	79632


# Concentration_[Abnormal]:
N/A	0.014 +/- 0.001	uM	Adult:>18_yrs_old	Both	Benign Prostatic Hyperplasia (Prostate tissue)	79632


# Associated_Disorders:
21-Hydroxylase Deficiency (CYP21); 3-Beta-Hydroxysteroid Dehydrogenase Deficiency; Benign Prostatic Hyperplasia (Prostate tissue); Hyperinsulinemia; Hypothyroidism; Ullrich Turner Syndrome

# Pathway_Names:
Pentose and glucuronate interconversions;Androgen and estrogen metabolism;Starch and sucrose metabolism;Porphyrin and chlorophyll metabolism;Prostaglandin and leukotriene metabolism;Bile acid biosynthesis;C21-Steroid hormone metabolism

# Pathway_Images:
;;;;;;

# KEGG_Images:
map00040;map00150;map00500;map00860;map0059;map00120;map00140

# Pathway_Graphs:
;;;;;;

# Pathway_SBMLs:
;;;;;;

# Metabolic_Enzyme_1_ID:
5722

# Metabolic_Enzyme_1_Name:
UDP-glucuronosyltransferase 2B15 precursor

# Metabolic_Enzyme_1_Synonyms:
UDPGT; UDPGTh-3; HLUG4

# Metabolic_Enzyme_1_Gene_Name:
UGT2B15

# Metabolic_Enzyme_1_Protein_Sequence:
>UDPglucuronosyltransferase 2B15 precursor
MSLKWTSVFLLIQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVTVLTSSA
STLVNASKSSAIKLEVYPTSLTKNDLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEY
YDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGELLAELFNIPFLYSLRFSVGYT
FEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYSEV
LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
MSSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVA
AHNLTWIQYHSLDVIAFLLACVATVIFIITKFCLFCFRKLAKKGKKKKRD

# Metabolic_Enzyme_1_Number_of_Residues:
530

# Metabolic_Enzyme_1_Molecular_Weight:
60989

# Metabolic_Enzyme_1_Theoretical_pI:
9.04

# Metabolic_Enzyme_1_GO_Classification:
Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens

# Metabolic_Enzyme_1_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_1_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_1_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_1_Signals:
1-23

# Metabolic_Enzyme_1_Transmembrane_Regions:
495-515

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_1_GenBank_ID_Protein:
23955933

# Metabolic_Enzyme_1_SwissProt_ID:
UDB15_HUMAN (P54855)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
UGT2B15

# Metabolic_Enzyme_1_Geneatlas_id:
UGT2B15

# Metabolic_Enzyme_1_hgnc_id:
HGNC:12546

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Microsome

# Metabolic_Enzyme_1_Gene_Sequence:
>1593 bp
ATGTCTCTGAAATGGACGTCAGTCTTTCTGCTGATACAGCTCAGTTGTTACTTTAGCTCT
GGAAGCTGTGGAAAGGTGCTAGTGTGGCCCACAGAATACAGCCATTGGATAAATATGAAG
ACAATCCTGGAAGAGCTTGTTCAGAGGGGTCATGAGGTGACTGTGTTGACATCTTCGGCT
TCTACTCTTGTCAATGCCAGTAAATCATCTGCTATTAAATTAGAAGTTTATCCTACATCT
TTAACTAAAAATGATTTGGAAGATTCTCTTCTGAAAATTCTCGATAGATGGATATATGGT
GTTTCAAAAAATACATTTTGGTCATATTTTTCACAATTACAAGAATTGTGTTGGGAATAT
TATGACTACAGTAACAAGCTCTGTAAAGATGCAGTTTTGAATAAGAAACTTATGATGAAA
CTACAAGAGTCAAAGTTTGATGTCATTCTGGCAGATGCCCTTAATCCCTGTGGTGAGCTA
CTGGCTGAACTATTTAACATACCCTTTCTGTACAGTCTTCGATTCTCTGTTGGCTACACA
TTTGAGAAGAATGGTGGAGGATTTCTGTTCCCTCCTTCCTATGTACCTGTTGTTATGTCA
GAATTAAGTGATCAAATGATTTTCATGGAGAGGATAAAAAATATGATACATATGCTTTAT
TTTGACTTTTGGTTTCAAATTTATGATCTGAAGAAGTGGGACCAGTTTTATAGTGAAGTT
CTAGGAAGACCCACTACATTATTTGAGACAATGGGGAAAGCTGAAATGTGGCTCATTCGA
ACCTATTGGGATTTTGAATTTCCTCGCCCATTCTTACCAAATGTTGATTTTGTTGGAGGA
CTTCACTGTAAACCAGCCAAACCCCTGCCTAAGGAAATGGAAGAGTTTGTGCAGAGCTCT
GGAGAAAATGGTATTGTGGTGTTTTCTCTGGGGTCGATGATCAGTAACATGTCAGAAGAA
AGTGCCAACATGATTGCATCAGCCCTTGCCCAGATCCCACAAAAGGTTCTATGGAGATTT
GATGGCAAGAAGCCAAATACTTTAGGTTCCAATACTCGACTGTACAAGTGGTTACCCCAG
AATGACCTTCTTGGTCATCCCAAAACCAAAGCTTTTATAACTCATGGTGGAACCAATGGC
ATCTATGAGGCGATCTACCATGGGATCCCTATGGTGGGCATTCCCTTGTTTGCGGATCAA
CATGATAACATTGCTCACATGAAAGCCAAGGGAGCAGCCCTCAGTGTGGACATCAGGACC
ATGTCAAGTAGAGATTTGCTCAATGCATTGAAGTCAGTCATTAATGACCCTGTCTATAAA
GAGAATGTCATGAAATTATCAAGAATTCATCATGACCAACCAATGAAGCCCCTGGATCGA
GCAGTCTTCTGGATTGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTTCGAGTCGCA
GCTCACAACCTCACCTGGATCCAGTACCACTCTTTGGATGTGATAGCATTCCTGCTGGCC
TGCGTGGCAACTGTGATATTTATCATCACAAAATTTTGCCTGTTTTGTTTCCGAAAGCTT
GCCAAAACAGGAAAGAAGAAGAAAAGAGATTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF548389

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_1_Locus:
4q13

# Metabolic_Enzyme_1_SNPs:
rs6825560; rs988562; rs1120265; rs1960773; rs7686914; rs988560; rs6839555; rs7682027; rs3100; rs9994887; rs1580083; rs7377952; rs7696472; rs6825748; rs13128530; rs1968719; rs1968718; rs7654523; rs1026337; rs1947435; rs1026338; rs2278917; rs1160212; rs12500760; rs4048844; rs7377954; rs12647504; rs4148271; rs2168050; rs2168051; rs6858676; rs35791822; rs13112099; rs7377950; rs34930215; rs17324486; rs5017546; rs2877378; rs1947434; rs5017549; rs17221777; rs35601514; rs6839657; rs11371462; rs5017544; rs2331421; rs2331422; rs6820752; rs4694747; rs12108552; rs34214136; rs4426857; rs35503231; rs5017548; rs35397066; rs5859136; rs2877377; rs10549990; rs2331423; rs5017545; rs34618890; rs5017547; rs5029385; rs1026339; rs5859137; rs34498614; rs34207963; rs3966095; rs1902023; rs4148269

# Metabolic_Enzyme_1_General_References:
7835232; 9295060; 2116769

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5596

# Metabolic_Enzyme_2_Name:
Aldo-keto reductase family 1 member C3

# Metabolic_Enzyme_2_Synonyms:
Trans-1,2- dihydrobenzene-1,2-diol dehydrogenase; 3-alpha- hydroxysteroid dehydrogenase type 2; 3-alpha-HSD type 2; 3-alpha-HSD type II, brain; Prostaglandin F synthase; PGFS; Estradiol 17-beta-dehydrogenase; 17-beta-hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5; Chlordecone reductase homolog HAKRb; HA1753; Dihydrodiol dehydrogenase type I; Dihydrodiol dehydrogenase 3; DD3; DD-3

# Metabolic_Enzyme_2_Gene_Name:
AKR1C3

# Metabolic_Enzyme_2_Protein_Sequence:
>Aldoketo reductase family 1 member C3
MDSKQQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
RNLHYFNSDSFASHPNYPYSDEY

# Metabolic_Enzyme_2_Number_of_Residues:
323

# Metabolic_Enzyme_2_Molecular_Weight:
36845

# Metabolic_Enzyme_2_Theoretical_pI:
8.06

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9alpha,11beta- PGF2 to PGD2. Functions as a bi-directional 3alpha-, 17beta- and 20alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone

# Metabolic_Enzyme_2_Pathway:
map00590  Prostaglandin and leukotriene metabolism

# Metabolic_Enzyme_2_Reaction:
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.3.1.20;EC 1.1.1.213;

# Metabolic_Enzyme_2_GenBank_ID_Protein:
4261711

# Metabolic_Enzyme_2_SwissProt_ID:
AK1C3_HUMAN (P42330)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
AKR1C3

# Metabolic_Enzyme_2_Geneatlas_id:
AKR1C3

# Metabolic_Enzyme_2_hgnc_id:
HGNC:386

# Metabolic_Enzyme_2_PDB_ID:
1XF0

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>972 bp
ATGGATTCCAAACAGCAGTGTGTAAAGCTAAATGATGGCCACTTCATGCCTGTATTGGGA
TTTGGCACCTATGCACCTCCAGAGGTTCCGAGAAGTAAAGCTTTGGAGGTCACAAAATTA
GCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCATTTATACAATAATGAGGAGCAG
GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTTGAGAGAGAAGACATATTC
TACACTTCAAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGTCCGACCAGCCTTGGAA
AACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCTCTATCTTATTCATTCTCCAATG
TCTCTAAAGCCAGGTGAGGAACTTTCACCAACAGATGAAAATGGAAAAGTAATATTTGAC
ATAGTGGATCTCTGTACCACCTGGGAGGCCATGGAGAAGTGTAAGGATGCAGGATTGGCC
AAGTCCATTGGGGTATCAAACTTCAACCGCAGGCAGCTGGAGATCATCCTCAACAAGCCA
GGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCGTATTTCAACCGGAGT
AAATTGCTAGATTTCTGCAAGTCGAAAGATATTGTTCTGGTTGCCTATAGTGCTCTGGGA
TCTCAACGAGACAAACGATGGGTGGACCCGAACTCCCCGGTCCTCTTGGAGGACCCAGTC
CTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAG
CTGCAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAAC
GTGCAGGTTTTTGAGTTCCAGTTGACTGCAGAGGACATGAAAGCCATAGATGGCCTAGAC
AGAAATCTCCACTATTTTAACAGTGATAGTTTTGCTAGCCACCCTAATTATCCATATTCA
GATGAATATTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
S68288

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_2_Locus:
10p15-p14

# Metabolic_Enzyme_2_SNPs:
rs12529; rs1804062; rs35575889; rs34186955; rs35961894; rs12387; rs1937839; rs28943574; rs7741; rs3209896; rs1937840; rs2801883; rs2275928; rs2245191; rs1937843; rs2154309; rs9329316; rs11252951; rs4641368; rs4478887; rs7076063; rs4242785; rs10508294; rs4512728; rs10904418; rs9888062; rs2298305; rs2518049; rs4881400; rs7917546; rs2801882; rs17173403; rs7091485; rs2154307; rs10795245; rs11252945; rs11252941; rs33921818; rs17155732; rs1937841; rs11252942; rs33979906; rs11252943; rs12769666; rs12775701; rs9888075; rs10508293; rs11252944; rs2154306; rs10160019; rs3750566; rs11252950; rs10904416; rs12242350; rs11252939; rs35768949; rs12267712; rs35567055; rs34760938; rs34936429; rs36050091; rs4987101; rs17396032; rs11252940; rs7090349; rs4559587; rs35955223; rs12244591; rs11252946; rs4347280; rs34291069; rs36003741; rs12775913; rs17134355; rs34320249; rs7920141; rs36204597; rs2339; rs34140485; rs4584484; rs10904417; rs4584485; rs34304688; rs12775922; rs35983920; rs9329315; rs35047456; rs4264066; rs12782982; rs12244584; rs10904419; rs34335319; rs3763676; rs10904421; rs11818810; rs10904415; rs11252935; rs1937845; rs7894034; rs2518047; rs17134359; rs11252936; rs36000531; rs34516592; rs34722940; rs35483669; rs35531692; rs11252937; rs28942669; rs11551178; rs1131132; rs4987102; rs41306308; rs1804059; rs28943579; rs7342072; rs17849485; rs1131124; rs1804061; rs1804060; rs6581; rs28943581; rs28943582; rs35460332; rs35951787; rs35498365; rs34464507; rs3996506; rs11273607; rs34805426; rs35558480; rs34376012; rs12219397; rs1937844; rs4987103; rs12775924; rs34401009; rs35550189; rs11252947; rs7913166; rs35859199; rs34365063; rs35516441; rs7089963; rs2298304; rs41306310; rs35338655; rs34942947; rs34429432; rs12413055; rs34774984; rs11252948; rs35174293; rs10637298; rs5782801; rs28758366; rs7090071; rs34977292; rs10654845; rs35681139; rs10637297; rs11270349; rs35857003; rs11252938; rs3216070; rs35888676; rs34948891; rs34791059; rs5782800; rs11252949; rs34835891; rs35156069; rs11592217; rs34747896; rs28943578; rs34819103; rs11819187; rs5782802; rs34506108; rs34070010; rs35613411; rs35843850; rs28943577; rs36201177; rs35754932; rs1937846; rs35143522; rs28943576; rs35288974; rs10904422; rs10904423; rs10904428; rs11252931; rs11252932; rs11252934; rs11252955; rs11252960; rs11813521; rs12263243; rs12354530; rs12414038; rs17134288; rs1937847; rs1937848; rs1937849; rs1937905; rs1937906; rs2211624; rs2211625; rs2211630; rs2226260; rs34706100; rs4636560; rs4880708; rs4880709; rs4880710; rs7068685; rs7070041; rs7086771; rs7088288; rs7477623; rs7478099; rs7904863; rs7917079; rs7921327

# Metabolic_Enzyme_2_General_References:
8274401; 7650035; 7626489; 9415401; 10622721; 10557352; 10672042; 11165022; 7788527; 9927279

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5731

# Metabolic_Enzyme_3_Name:
UDP-glucuronosyltransferase 2B17 precursor

# Metabolic_Enzyme_3_Synonyms:
UDPGT; C19- steroid-specific UDP-glucuronosyltransferase

# Metabolic_Enzyme_3_Gene_Name:
UGT2B17

# Metabolic_Enzyme_3_Protein_Sequence:
>UDPglucuronosyltransferase 2B17 precursor
MSLKWMSVFLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSA
SILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEY
SDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYT
VEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEV
LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
MSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVA
AHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLFCFRKLAKTGKKKKRD

# Metabolic_Enzyme_3_Number_of_Residues:
530

# Metabolic_Enzyme_3_Molecular_Weight:
61096

# Metabolic_Enzyme_3_Theoretical_pI:
8.73

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3alpha,17beta-diol (3alpha-diol) > testosterone > androsterone (ADT)

# Metabolic_Enzyme_3_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_3_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_3_Signals:
1-23

# Metabolic_Enzyme_3_Transmembrane_Regions:
495-515

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_3_GenBank_ID_Protein:
3287473

# Metabolic_Enzyme_3_SwissProt_ID:
UDB17_HUMAN (O75795)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
UGT2B17

# Metabolic_Enzyme_3_Geneatlas_id:
UGT2B17

# Metabolic_Enzyme_3_hgnc_id:
HGNC:12547

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Microsome

# Metabolic_Enzyme_3_Gene_Sequence:
>1593 bp
ATGTCTCTGAAATGGATGTCAGTCTTTCTGCTGATGCAGCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATACAGCCATTGGATAAATATGAAG
ACAATCCTGGAAGAGCTTGTTCAGAGGGGTCATGAGGTGATTGTGTTGACATCTTCGGCT
TCTATTCTTGTCAATGCCAGTAAATCATCTGCTATTAAATTAGAAGTTTATCCTACATCT
TTAACTAAAAATGATTTGGAAGATTTTTTTATGAAAATGTTCGATAGATGGACATATAGT
ATTTCAAAAAATACATTTTGGTCATATTTTTCACAACTACAAGAATTGTGTTGGGAATAT
TCTGACTATAATATAAAGCTCTGTGAAGATGCAGTTTTGAACAAGAAACTTATGAGAAAA
CTACAAGAGTCAAAATTTGATGTCCTTCTGGCAGATGCCGTTAATCCCTGTGGTGAGCTG
CTGGCTGAACTACTTAACATACCCTTTCTGTACAGTCTCCGCTTCTCTGTTGGCTACACA
GTTGAGAAGAATGGTGGAGGATTTCTGTTCCCTCCTTCCTATGTACCTGTTGTTATGTCA
GAATTAAGTGATCAAATGATTTTCATGGAGAGGATAAAAAATATGATATATATGCTTTAT
TTTGACTTTTGGTTTCAAGCATATGATCTGAAGAAGTGGGACCAGTTTTATAGTGAAGTT
CTAGGAAGACCCACTACATTATTTGAGACAATGGGGAAAGCTGAAATGTGGCTCATTCGA
ACCTATTGGGATTTTGAATTTCCTCGCCCATTCTTACCAAATGTTGATTTTGTTGGAGGA
CTTCACTGTAAACCAGCCAAACCCTTGCCTAAGGAAATGGAAGAGTTTGTGCAGAGCTCT
GGAGAAAATGGTATTGTGGTGTTTTCTCTGGGGTCGATGATCAGTAACATGTCAGAAGAA
AGTGCCAACATGATTGCATCAGCCCTTGCCCAGATCCCACAAAAGGTTCTATGGAGATTT
GATGGCAAGAAGCCAAATACTTTAGGTTCCAATACTCGACTGTATAAGTGGTTACCCCAG
AATGACCTTCTTGGTCATCCCAAAACCAAAGCTTTTATAACTCATGGTGGAACCAATGGC
ATCTATGAGGCGATCTACCATGGGATCCCTATGGTGGGCATTCCCTTGTTTGCGGATCAA
CATGATAACATTGCTCACATGAAAGCCAAGGGAGCAGCCCTCAGTGTGGACATCAGGACC
ATGTCAAGTAGAGATTTGCTCAATGCATTGAAGTCAGTCATTAATGACCCTATCTATAAA
GAGAATATCATGAAATTATCAAGAATTCATCATGATCAACCGGTGAAGCCCCTGGATCGA
GCAGTCTTCTGGATTGAGTTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTCGCA
GCCCACAACCTCACCTGGATCCAGTACCACTCTTTGGATGTGATAGCATTCCTGCTGGCC
TGCGTGGCAACTATGATATTTATGATCACAAAATGTTGCCTGTTTTGTTTCCGAAAGCTT
GCCAAAACAGGAAAGAAGAAGAAAAGGGATTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U59209

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
8798464; 9364925

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5732

# Metabolic_Enzyme_4_Name:
UDP-glucuronosyltransferase 1-6 precursor

# Metabolic_Enzyme_4_Synonyms:
UDP- glucuronosyltransferase 1A6; UDPGT; UGT1*6; UGT1-06; UGT1.6; UGT- 1F; UGT1F; Phenol-metabolizing UDP-glucuronosyltransferase

# Metabolic_Enzyme_4_Gene_Name:
UGT1A6

# Metabolic_Enzyme_4_Protein_Sequence:
>UDPglucuronosyltransferase 16 precursor
MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVV
PEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIG
LYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEH
TFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRD
VDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHG
IVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLL
GHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSE
DLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDL
TWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_4_Number_of_Residues:
532

# Metabolic_Enzyme_4_Molecular_Weight:
60751

# Metabolic_Enzyme_4_Theoretical_pI:
8.55

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols

# Metabolic_Enzyme_4_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_4_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_4_Signals:
1-26

# Metabolic_Enzyme_4_Transmembrane_Regions:
490-506

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_4_GenBank_ID_Protein:
340141

# Metabolic_Enzyme_4_SwissProt_ID:
UD16_HUMAN (P19224)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
UGT1A6

# Metabolic_Enzyme_4_Geneatlas_id:
UGT1A6

# Metabolic_Enzyme_4_hgnc_id:
HGNC:12538

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Microsome

# Metabolic_Enzyme_4_Gene_Sequence:
>861 bp
ATGGCCTGCCTCCTTCGCTCATTTCAGAGAATTTCTGCAGGGGTTTTCTTCTTAGCACTT
TGGGGCATGGTTGTAGGTGACAAGCTGCTGGTGGTCCCTCAGGACGGAAGCCACTGGCTT
AGTATGAAGGATATAGTTGAGGTTCTCAGTGACCGGGGTCATGAGATTGTAGTGGTGGTG
CCTGAAGTTAATTTGCTTTTGAAAGAATCCAAATACTACACAAGAAAAATCTATCCAGTG
CCGTATGACCAAGAAGAGCTGAAGAACCGTTACCAATCATTTGGAAACAATCACTTTGCT
GAGCGATCATTCCTAACTGCTCCTCAGACAGAGTACAGGAATAACATGATTGTTATTGGC
CTGTACTTCATCAACTGCCAGAGCCTCCTGCAGGACAGGGACACCCTGAACTTCTTTAAG
GAGAGCAAGTTTGATGCTCTTTTCACAGACCCAGCCTTACCCTGTGGGGTGATCCTGGCT
GAGTATTTGGGCCTACCATCTGTGTACCTCTTCAGGGGTTTTCCGTGTTCCCTGGAGCAT
ACATTCAGCAGAAGCCCAGACCCTGTGTCCTACATTCCCAGGTGCTACACAAAGTTTTCA
GACCACATGACTTTTTCCCAACGAGTGGCCAACTTCCTTGTTAATTTGTTGGAGCCCTAT
CTATTTTATTGTCTGTTTTCAAAGTATGAAGAACTCGCATCAGCTGTCCTCAAGAGAGAT
GTGGATATAATCACCTTATATCAGAAGGTCTCTGTTTGGCTGTTAAGATATGACTTTGTG
CTTGAATATCCTAGGCCGGTCATGCCCAACATGGTCTTCATTGGAGGTATCAACTGTAAG
AAGAGGAAAGACTTGTCTCAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M84130

# Metabolic_Enzyme_4_Chromosome_Location:
Not Available

# Metabolic_Enzyme_4_Locus:
Not Available

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
1339448; 3141926; 11434514; 9466822; 9429234

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5696

# Metabolic_Enzyme_5_Name:
UDP-glucuronosyltransferase 2B4 precursor

# Metabolic_Enzyme_5_Synonyms:
UDPGT; Hyodeoxycholic acid; HLUG25; UDPGTh-1

# Metabolic_Enzyme_5_Gene_Name:
UGT2B4

# Metabolic_Enzyme_5_Protein_Sequence:
>UDPglucuronosyltransferase 2B4 precursor
MSMKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLASSA
SISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFN
DILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFGELLAELLKIPFVYSLRFSPGYAI
EKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVL
GRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSMVSNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTM
SSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVTGFLLACVATVIFIITKCLFCVWKFVRTGKKGKRD

# Metabolic_Enzyme_5_Number_of_Residues:
528

# Metabolic_Enzyme_5_Molecular_Weight:
60513

# Metabolic_Enzyme_5_Theoretical_pI:
8.75

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid

# Metabolic_Enzyme_5_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_5_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_5_Signals:
1-23

# Metabolic_Enzyme_5_Transmembrane_Regions:
493-509

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_5_GenBank_ID_Protein:
37589

# Metabolic_Enzyme_5_SwissProt_ID:
UDB4_HUMAN (P06133)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
UGT2B4

# Metabolic_Enzyme_5_Geneatlas_id:
UGT2B4

# Metabolic_Enzyme_5_hgnc_id:
HGNC:12553

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Microsome

# Metabolic_Enzyme_5_Gene_Sequence:
>1587 bp
ATGTCTATGAAATGGACTTCAGCTCTTCTGCTGATACAGCTGAGCTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATTCAGCCACTGGATGAATATAAAG
ACAATCCTGGATGAACTTGTCCAGAGAGGTCATGAGGTGACTGTATTGGCATCTTCAGCT
TCCATTTCTTTCGATCCCAACAGCCCATCTACTCTTAAATTTGAAGTTTATCCTGTATCT
TTAACTAAAACTGAGTTTGAGGATATTATCAAGCAGCTGGTTAAGAGATGGGCAGAACTT
CCAAAAGACACATTTTGGTCATATTTTTCACAAGTACAAGAAATCATGTGGACATTTAAT
GACATACTTAGAAAGTTCTGTAAGGATATAGTTTCAAATAAGAAACTTATGAAGAAACTA
CAGGAGTCAAGATTTGATGTTGTTCTTGCAGATGCTGTTTTCCCCTTTGGTGAGCTGCTG
GCCGAGTTACTTAAAATACCCTTTGTCTACAGGCCTCGCTTCTCTCCTGGCTACGCAATT
GAAAAGCATAGTGGAGGACTTCTGTTCCCTCCTTCCTATGTGCCTGTTGTTATGTCAGAA
CTAAGTGACCAAATGACTTTCATAGAGAGGGTAAAAAATATGATCTATGTGCTTTATTTT
GAATTTTGGTTCCAAATATTTGACATGAAGAAGTGGGATCAGTTCTACAGTGAAGTTCTA
GGAAGACCCACTACGTTATCTGAGACAATGGCAAAAGCTGACATATGGCTTATTCGAAAC
TACTGGGATTTTCAATTTCCTCACCCACTCTTACCAAATGTTGAGTTCGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTACCGAAGGAAATGGAAGAGTTTGTCCAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCGATGGTCAGTAACACGTCAGAAGAAAGG
GCCAATGTAATTGCATCAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATACTTTAGGACTCAATACTCGGCTGTACAAGTGGATACCCCAGAAT
GATCTTCTTGGTCACCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATAAGGCAATCTCTCCTAGAATCCCTATGGTGGGCGTTCCATTGTTTGCAGATCAACCT
GATAACATTGCACACATGAAGGCCAAGGGAGCAGCTGTTAGTTTGGACTTCCACACAATG
TCGAGTACAGACTTACTCAATGCACTGAAGACAGTAATTAATGATCCTTTATATAAAGAG
AATGCTATGAAATTATCAAGAATTCATCATGATCAACCAGTGAAGCCCCTTGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTTGCAGCC
CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGACTGGGTTCCTGCTGGCCTGT
GTGGCAACTGTGATATTCATCATCACAAAATGTCTGTTTTGTGTCTGGAAGTTTGTTAGA
ACAGGAAAGAAGGGGAAAAGAGATTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
Y00317

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_5_Locus:
4q13

# Metabolic_Enzyme_5_SNPs:
rs13119049; rs41297431; rs13142440; rs1131878; rs1966151; rs1051752; rs7662902; rs1389930; rs1826690; rs7441743; rs1039007; rs2220857; rs2013562; rs1845557; rs6833511; rs13116232; rs12645716; rs9997034; rs1994936; rs1039008; rs4554145; rs28542932; rs10030234; rs10518061; rs17614939; rs13104260; rs10010875; rs3822179; rs33914959; rs1845556; rs6848208; rs17671289; rs1977017; rs28361541; rs41297733; rs41297437; rs1997581; rs41297373; rs41299996; rs41297395; rs41297371; rs41300016; rs41297381; rs41297421; rs1908406; rs41297427; rs41297377; rs41297425; rs41297367; rs4557343; rs1845558; rs3075630; rs41297405; rs41297739; rs41297383; rs41297721; rs13151870; rs41297441; rs13145834; rs13104687; rs11249442; rs41297407; rs41297429; rs41297727; rs1121124; rs2013573; rs41299994; rs13139888; rs41297439; rs41297409; rs1494802; rs13111134; rs6600771; rs6820660; rs6821129; rs941389; rs2736446; rs1080755; rs2736442; rs28858389; rs2736441; rs41298271; rs41298263; rs41299972; rs41298261; rs41298251; rs13129471; rs41299970; rs6821910; rs41298253; rs41298259; rs41298265; rs41298245; rs41299978; rs41299976; rs41299974; rs41300004; rs17852375; rs1845555; rs41298247; rs28679647; rs324405; rs41300006; rs36048401; rs1432328; rs41297387; rs41299984; rs41299998; rs41299992; rs41297735; rs41297423; rs35143721; rs1370886; rs41299980; rs41297389; rs41297729; rs7441132; rs41297435; rs34002802; rs41297731; rs41300018; rs35138624; rs41297391; rs41297369; rs41297737; rs41297413; rs13141359; rs41292303; rs41300008; rs2736447; rs41300014; rs41297401; rs34874998; rs1370887; rs41297399; rs41297379; rs172861; rs41297375; rs10613760; rs41297433; rs41297723; rs41297403; rs41297741; rs1821190; rs34030380; rs324406; rs41299986; rs41297393; rs41297385; rs41297419; rs41297365; rs35471760; rs34861432; rs4515233; rs324408; rs41297411; rs2018304; rs41300012; rs13114834; rs41297415; rs28629208; rs41300002; rs41300000; rs41300010; rs41297743; rs41297397; rs41299990; rs28419590; rs983988; rs34164957; rs1370885; rs324407; rs34466016; rs41297725; rs41297417; rs34114694; rs41299988; rs41299982; rs41299966; rs34846583; rs35045255; rs35834953; rs34169605; rs1318156; rs2642856; rs35159034; rs41298257; rs41298249; rs2736445; rs3075626; rs41299968; rs28847667; rs34146174; rs36057237; rs28812576; rs941390; rs41298255; rs28894673; rs41298269; rs1080756; rs41298267; rs10000231; rs10015297; rs11725944; rs11725945; rs13141436; rs13143630; rs1569343; rs1569344; rs1594588; rs1603119; rs1948499; rs2010468; rs2642849; rs2642872; rs2736462; rs2736476; rs2736517; rs2736520; rs35347166; rs4694749; rs7657880; rs903445; rs903446; rs9996511

# Metabolic_Enzyme_5_General_References:
3109396; 8333863; 10376768

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5726

# Metabolic_Enzyme_6_Name:
UDP-glucuronosyltransferase 1-9 precursor

# Metabolic_Enzyme_6_Synonyms:
UDP- glucuronosyltransferase 1A9; UDPGT; UGT1*9; UGT1-9; UGT1.9; UGT- 1I; UGT1I; lugP4

# Metabolic_Enzyme_6_Gene_Name:
UGT1A9

# Metabolic_Enzyme_6_Protein_Sequence:
>UDPglucuronosyltransferase 19 precursor
MACTGWTSPLPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMRSVVEKLILRGHEVVVVMP
EVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLF
FSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNCGLIVAKYFSLPSVVFARGILCHYLEEG
AQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLLCHRFFKNALEIASEILQTPVT
EYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_6_Number_of_Residues:
530

# Metabolic_Enzyme_6_Molecular_Weight:
59942

# Metabolic_Enzyme_6_Theoretical_pI:
7.96

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols

# Metabolic_Enzyme_6_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_6_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_6_Signals:
1-25

# Metabolic_Enzyme_6_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_6_GenBank_ID_Protein:
7690346

# Metabolic_Enzyme_6_SwissProt_ID:
UD19_HUMAN (O60656)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
UGT1A9

# Metabolic_Enzyme_6_Geneatlas_id:
UGT1A9

# Metabolic_Enzyme_6_hgnc_id:
HGNC:12541

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Microsome

# Metabolic_Enzyme_6_Gene_Sequence:
>1593 bp
ATGGCTTGCACAGGGTGGACCAGCCCCCTTCCTCTATGTGTGTGTCTGCTGCTGACCTGT
GGCTTTGCCGAGGCAGGGAAGCTAGTGGTAGTGCCCATGGATGGGAGCCACTGGTTCACC
ATGAGGTCGGTGGTGGAGAAACTCATTCTCAGGGGGCATGAGGTGGTTGTAGTCAGTGCC
AGAGGTGAGTTGGCAACTGGGAAGATCAATGAATTGCACAGTGAAGACTTATTCAACTTC
ATATACCTGGAGGATCTGGACCGGGAGTTCAAGGCTTTTGCCCATGCTCAATGGAAAGCA
CAAGTACGAAGTATATATTCTCTATTAATGGGTTCATACAATGACATTTTTGACTTATTT
TTTTCAAATTGCAGGAGTTTGTTTAAAGACAAAAAATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCAGTGTTTCTCGATCCTTTTGATAACTGTGGCTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCCGTGGTCTTCGCCAGGGGAATACTTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGAATTCTCTTAGGGTTCTCAGATGAC
ATGACTTTCAAGGAGAGAGTACGGAACCACATCATGCACTTGGAGGAACATTTATTATGC
CACCGTTTTTTCAAAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACACCTGTTACG
GAGTATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACGGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAACATGATCTTCATTGGTGGTATCAACTGCCATGAGAGG
AAAGCGTTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GGTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATGC
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCAGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCATGAATGTTCTGGAAATGACTTCTGAAGAATTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTTATGAGGCACAAGGGCGCGACACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGCCGTGCTGACAGTGGCC
TTCATCACCTGTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
S55985

# Metabolic_Enzyme_6_Chromosome_Location:
Not Available

# Metabolic_Enzyme_6_Locus:
Not Available

# Metabolic_Enzyme_6_SNPs:
Not Available

# Metabolic_Enzyme_6_General_References:
1910331; 11434514

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5623

# Metabolic_Enzyme_7_Name:
Aldo-keto reductase family 1 member C1

# Metabolic_Enzyme_7_Synonyms:
20-alpha- hydroxysteroid dehydrogenase; 20-alpha-HSD; Trans- 1,2-dihydrobenzene-1,2-diol dehydrogenase; High- affinity hepatic bile acid-binding protein; HBAB; Chlordecone reductase homolog HAKRC; Dihydrodiol dehydrogenase 1/2; DD1/DD2

# Metabolic_Enzyme_7_Gene_Name:
AKR1C1

# Metabolic_Enzyme_7_Protein_Sequence:
>Aldoketo reductase family 1 member C1
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
RNVRYLTLDIFAGPPNYPFSDEY

# Metabolic_Enzyme_7_Number_of_Residues:
323

# Metabolic_Enzyme_7_Molecular_Weight:
36789

# Metabolic_Enzyme_7_Theoretical_pI:
7.99

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Converts progesterone to its inactive form, 20alpha- dihydroxyprogesterone (20alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. May play a role in myelin formation

# Metabolic_Enzyme_7_Pathway:
map00140  C21-Steroid hormone metabolism

# Metabolic_Enzyme_7_Reaction:
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.1.1.149;EC 1.3.1.20

# Metabolic_Enzyme_7_GenBank_ID_Protein:
181549

# Metabolic_Enzyme_7_SwissProt_ID:
AK1C1_HUMAN (Q04828)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
AKR1C1

# Metabolic_Enzyme_7_Geneatlas_id:
AKR1C1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:384

# Metabolic_Enzyme_7_PDB_ID:
1MRQ

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_7_Gene_Sequence:
>972 bp
ATGGATTCGAAATATCAGTGTGTGAAGCTGAATGATGGTCACTTCATGCCTGTCCTGGGA
TTTGGCACCTATGCGCCTGCAGAGGTTCCTAAAAGTAAAGCTTTAGAGGCCACCAAATTG
GCAATTGAAGCTGGCTTCCGCCATATTGATTCTGCTCATTTATACAATAATGAGGAGCAG
GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTC
TACACTTCAAAGCTTTGGTGCAATTCCCATCGACCAGAGTTGGTCCGACCAGCCTTGGAA
AGGTCACTGAAAAATCTTCAATTGGATTATGTTGACCTCTACCTTATTCATTTTCCAGTG
TCTGTAAAGCCAGGTGAGGAAGTGATCCCAAAAGATGAAAATGGAAAAATACTATTTGAC
ACAGTGGATCTCTGTGCCACGTGGGAGGCCGTGGAGAAGTGTAAAGATGCAGGATTGGCC
AAGTCCATCGGGGTGTCCAACTTCAACCGCAGGCAGCTGGAGATGATCCTCAACAAGCCA
GGGCTCAAGTACAAGCCTGTCTGCAACCAGGTGGAATGTCATCCTTACTTCAACCAGAGA
AAACTGCTGGATTTCTGCAAGTCAAAAGACATTGTTCTGGTTGCCTATAGTGCTCTGGGA
TCCCACCGAGAAGAACCATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTC
CTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAG
CTACAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAAC
GTGCAGGTGTTTGAATTCCAGTTGACTTCAGAGGAGATGAAAGCCATAGATGGCCTAAAC
AGAAATGTGCGATATTTGACCCTTGATATTTTTGCTGGCCCCCCTAATTATCCATTTTCT
GATGAATATTAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
M86609

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_7_Locus:
10p15-p14

# Metabolic_Enzyme_7_SNPs:
rs8483; rs35763015; rs35289491; rs7076886; rs7083234; rs3925947; rs4445550; rs3890593; rs2904802; rs2904804; rs2961611; rs7073738; rs3927919; rs7893456; rs12571627; rs3923936; rs7083246; rs7908994; rs4242782; rs2023630; rs35578180; rs1468085; rs7089378; rs3927918; rs10128163; rs6650153; rs7916644; rs5001364; rs2904799; rs6601881; rs3927917; rs3927913; rs12264914; rs11815346; rs7074155; rs1468084; rs12263850; rs12256271; rs7916500; rs3890643; rs3898029; rs1139139; rs4881373; rs2904795; rs11252852; rs1138575; rs1138569; rs1138570; rs1138571; rs1138576; rs15986; rs1138567; rs1138600; rs1138573; rs11548049; rs1138566; rs7097713; rs1138574; rs7069696; rs10562538; rs12263706; rs3925302; rs6143754; rs12250190; rs35909591; rs11252855; rs34344919; rs3923937; rs10685217; rs34098462; rs35308766; rs33990529; rs12264439; rs36033871; rs7069625; rs5782795; rs10595294; rs41305675; rs10664133; rs41298222; rs10128236; rs3927914; rs5010127; rs3930966; rs11330324; rs2961613; rs2518036; rs12254797; rs7087263; rs41305663; rs41314242; rs35816821; rs28451635; rs41298224; rs35617876; rs12773163; rs7085135; rs12256328; rs41305667; rs2904798; rs41314625; rs2961612; rs28464583; rs28580360; rs35691694; rs5001363; rs2904801; rs3930965; rs2518035; rs5782794; rs41305661; rs12241237; rs11252853; rs2854470; rs11310552; rs41305677; rs11252864; rs2904800; rs2904803; rs34581211; rs4255441; rs6601882; rs6601887; rs6601888; rs7068923; rs7909151; rs7914666; rs7915338

# Metabolic_Enzyme_7_General_References:
8486699; 8132567; 7626489; 10672042; 11013348; 8274401; 8172617; 12899831

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5730

# Metabolic_Enzyme_8_Name:
UDP-glucuronosyltransferase 1-10 precursor

# Metabolic_Enzyme_8_Synonyms:
UDPGT; UGT1*10; UGT1-10; UGT1.10; UGT-1J; UGT1J

# Metabolic_Enzyme_8_Gene_Name:
UGT1A10

# Metabolic_Enzyme_8_Protein_Sequence:
>UDPglucuronosyltransferase 110 precursor
MARAGWTSPVPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLF
FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEG
AQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_8_Number_of_Residues:
530

# Metabolic_Enzyme_8_Molecular_Weight:
59810

# Metabolic_Enzyme_8_Theoretical_pI:
7.31

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_8_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_8_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_8_Signals:
1-25

# Metabolic_Enzyme_8_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_8_GenBank_ID_Protein:
2039362

# Metabolic_Enzyme_8_SwissProt_ID:
UD110_HUMAN (Q9HAW8)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
UGT1A10

# Metabolic_Enzyme_8_Geneatlas_id:
UGT1A10

# Metabolic_Enzyme_8_hgnc_id:
HGNC:12531

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Microsome

# Metabolic_Enzyme_8_Gene_Sequence:
>1593 bp
ATGGCTCCGCGCAGGGTGGACCAGCCCCGTTCCTTTATGTGTGTGTCTACTGCTGACCTG
TGGCTTTGCGAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGTCACTGGTTCGCC
ATGCAGTCGGTGGTGGAGAAACTTATCCTCAGGGGGCATGAGGTGGTTGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGAAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCG
TACACTCTGGAAGATCAGAACCGGGAATTCATGGTTTTCGCCCATGCTCAATGGAAAGCA
CAGGCACAAAGTATATTTTCTCTATTAATGAGTTCATCCAGTGGTTTTCTTGACTTATTT
TTTTCGCATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCAGTGTTTCTGGATCCTTTTGATACCTGTGGCTTAATTGTTGCTAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCACCAGGGGAATATTTTGCCGCCATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAATGATCTCTTAGGGTTCTCAGATGCC
ATGACTTTCAAGGAGAGAGTATGGAACCACATCGTGCACTTGGAGGACCATTTATTTTGC
CAGTATCTTTTAAGAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGTCACACATCAATTTGGTTGTTGCGAACGGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAACATGATCTTCATTGGTGGTATCAACTGTCATCAGGGA
AAGCCATTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
U89508

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_8_Locus:
2q37

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
9271343; 11434514

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5727

# Metabolic_Enzyme_9_Name:
UDP-glucuronosyltransferase 1-8 precursor

# Metabolic_Enzyme_9_Synonyms:
UDP- glucuronosyltransferase 1A8; UDPGT; UGT1*8; UGT1-08; UGT1.8; UGT- 1H; UGT1H

# Metabolic_Enzyme_9_Gene_Name:
UGT1A8

# Metabolic_Enzyme_9_Protein_Sequence:
>UDPglucuronosyltransferase 18 precursor
MARTGWTSPIPLCVSLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLGKSLNCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLF
FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDACGLIVAKYFSLPSVVFARGIACHYLEEG
AQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLFCQYFSKNALEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_9_Number_of_Residues:
530

# Metabolic_Enzyme_9_Molecular_Weight:
59742

# Metabolic_Enzyme_9_Theoretical_pI:
7.73

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_9_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_9_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_9_Signals:
1-25

# Metabolic_Enzyme_9_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_9_GenBank_ID_Protein:
2613044

# Metabolic_Enzyme_9_SwissProt_ID:
UD18_HUMAN (Q9HAW9)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
UGT1A8

# Metabolic_Enzyme_9_Geneatlas_id:
UGT1A8

# Metabolic_Enzyme_9_hgnc_id:
HGNC:12540

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Microsome

# Metabolic_Enzyme_9_Gene_Sequence:
>1593 bp
ATGGCTCGCACAGGGTGGACCAGCCCCATTCCCCTATGTGTTTCTCTGCTGCTGACCTGT
GGCTTTGCTGAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGTCACTGGTTCACC
ATGCAGTCGGTGGTGGAGAAACTTATCCTCAGGGGGCATGAGGTGGTTGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGGAAAATCACTGAATTGCACAGTGAAGACTTACTCAACCTCA
TACACTCTGGAGGATCTGGACCGGGAATTCATGGATTTCGCCGATGCTCAATGGAAAGCA
CAAGTACGAAGTTTGTTTTCTCTATTTCTGAGTTCATCCAATGGTTTTTTTAACTTATTT
TTTTCGCATTGCAGGAGTTTGTTTAATGACCGAAGATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCGGTGTTTCTTGATCCTTTTGATGCCTGTGCGTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCGCCAGGGGAATAGGTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGAATTCTCTTAGGGTTCTCAGATGCC
ATGGCTTTCAAGGAGAGAGTACGGAACCACATCTTGCACTTGGAGGAACATTTATTTTGC
CAGTATTTTTCCAAAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACACCTGTCACA
GCATATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACAGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAATATGATCTTCATTGGTGGTATCAACTGCCATCAGGGA
AAGCCATTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AF030310

# Metabolic_Enzyme_9_Chromosome_Location:
Not Available

# Metabolic_Enzyme_9_Locus:
Not Available

# Metabolic_Enzyme_9_SNPs:
Not Available

# Metabolic_Enzyme_9_General_References:
9535849; 11434514; 12042666

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5687

# Metabolic_Enzyme_10_Name:
UDP-glucuronosyltransferase 2B28 precursor

# Metabolic_Enzyme_10_Synonyms:
UDPGT

# Metabolic_Enzyme_10_Gene_Name:
UGT2B28

# Metabolic_Enzyme_10_Protein_Sequence:
>UDPglucuronosyltransferase 2B28 precursor
MALKWTSVLLLIHLGCYFSSGSCGKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDIQKDSFWLYFSQEQEILWEFH
DIFRNFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTI
ERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWFQMCDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTM
SSTDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAA
RDLTWFQYHSLDVIGFLLACVATVIFVVTKFCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_10_Number_of_Residues:
529

# Metabolic_Enzyme_10_Molecular_Weight:
60907

# Metabolic_Enzyme_10_Theoretical_pI:
8.80

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta- diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active

# Metabolic_Enzyme_10_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_10_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_10_Signals:
1-24

# Metabolic_Enzyme_10_Transmembrane_Regions:
495-517

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_10_GenBank_ID_Protein:
13603476

# Metabolic_Enzyme_10_SwissProt_ID:
UDB28_HUMAN (Q9BY64)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
UGT2B28

# Metabolic_Enzyme_10_Geneatlas_id:
UGT2B28

# Metabolic_Enzyme_10_hgnc_id:
HGNC:13479

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Microsome

# Metabolic_Enzyme_10_Gene_Sequence:
>1590 bp
ATGGCTCTGAAGTGGACTTCAGTTCTTCTGCTGATACATCTCGGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGACCGGTGAATACAGCCATTGGATGAATATGAAG
ACAATCCTGAAAGAGCTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAATGACGCATTCACTCTTAAACTCGAAGTTTATCCTACATCT
TTAACTAAAACTGAATTTGAGAATATCATCATGCAACAGGTTAAGAGATGGTCAGACATT
CAAAAAGATAGCTTTTGGTTATATTTTTCACAAGAACAAGAAATCCTGTGGGAATTTCAT
GACATATTTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAAGTTATGAAAAAACTA
CAAGAGTCAAGATTTGACATCATTTTTGCAGATGCTTTTTTTCCTTGTGGTGAGCTGCTG
GCTGCGCTACTTAACATACCGTTTGTGTACAGTCTCTGCTTCACTCCTGGCTACACAATT
GAAAGGCACAGTGGAGGACTGATTTTCCCTCCTTCCTACATACCTGTTGTTATGTCAAAA
TTAAGTGATCAAATGACTTTCATGGAGAGGGTAAAAAACATGATCTATGTGCTTTATTTT
GACTTTTGGTTCCAAATGTGTGATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTA
GGAAGACCCACTACCTTATTTGAGACAATGGGGAAAGCTGACATATGGCTTATGCGAAAC
TCCTGGAGTTTTCAATTTCCTCATCCATTCTTACCAAACATTGATTTTGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAATTTGTACAGAGCTCTGGT
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAGTGATAAGTAACATGACAGCAGAAAGG
GCCAACGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATGCCTTAGGTCTCAATACTCGGCTGTATAAGTGGATACCCCAGAAT
GACCTTCTAGGTCTTCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATGAGGCAATCTACCATGGGATCCCTATGGTAGGCATTCCATTGTTTTGGGATCAACCT
GATAACATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGACTGGACTTCCACACAATG
TCGAGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTCATATAAAGAG
AATGTTATGAAATTATCAATAATTCAACATGATCAACCAGTAAAGCCCCTGCATCGAGCA
GTCTTCTGGATTGAATTTGTGATGTGCCACAAAGGAGCCAAACACCTTCGAGTTGCAGCC
CGTGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTTCTGCTGGCCTGT
GTGGCAACTGTGATATTTGTCGTCACAAAGTTTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGGGAAGAAGGGAAAAAGAGATTAG

# Metabolic_Enzyme_10_GenBank_ID_Gene:
AF177272

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_10_Locus:
4q13.2

# Metabolic_Enzyme_10_SNPs:
rs4235127; rs4260604; rs4386668; rs11726210; rs10002503; rs4235126; rs3901337; rs4260603; rs10008843; rs4694712; rs4301173; rs4694711; rs2132039; rs9997242; rs4260602; rs4235125; rs4694713; rs7686786; rs10000077; rs7437560; rs7681187; rs10023367; rs7657406; rs41292949; rs6843900; rs6828191; rs41292951; rs10013145; rs7689398; rs41292341; rs13139691; rs13138824; rs4569811; rs6827801; rs34313836; rs5004177; rs28376412; rs13108235; rs5004180; rs4295327; rs4568294; rs4450998; rs33966513; rs5004176; rs35191928; rs13107778; rs4345242; rs34549399; rs4495113; rs5004183; rs41292945; rs41292947; rs35437714; rs35925451; rs13146763; rs28447469; rs35059283; rs5004182; rs7435249; rs5004175; rs5859170; rs4515230; rs6840320; rs35572829; rs5004178; rs5004179; rs4597901; rs41292339; rs5004181; rs13116501; rs10011666; rs41292343; rs7657045; rs13124875; rs9991645; rs35680160; rs6600920

# Metabolic_Enzyme_10_General_References:
11300766

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5719

# Metabolic_Enzyme_11_Name:
UDP-glucuronosyltransferase 1-4 precursor

# Metabolic_Enzyme_11_Synonyms:
UDP- glucuronosyltransferase 1A4; UDPGT; UGT1*4; UGT1-04; UGT1.4; UGT- 1D; UGT1D; Bilirubin-specific UDPGT isozyme 2; HUG-BR2

# Metabolic_Enzyme_11_Gene_Name:
UGT1A4

# Metabolic_Enzyme_11_Protein_Sequence:
>UDPglucuronosyltransferase 14 precursor
MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVV
LTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNV
SLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDL
DFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQ
REVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_11_Number_of_Residues:
534

# Metabolic_Enzyme_11_Molecular_Weight:
60026

# Metabolic_Enzyme_11_Theoretical_pI:
8.68

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

# Metabolic_Enzyme_11_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_11_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_11_Signals:
1-28

# Metabolic_Enzyme_11_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_11_GenBank_ID_Protein:
340137

# Metabolic_Enzyme_11_SwissProt_ID:
UD14_HUMAN (P22310)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
UGT1A4

# Metabolic_Enzyme_11_Geneatlas_id:
UGT1A4

# Metabolic_Enzyme_11_hgnc_id:
HGNC:12536

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Microsome

# Metabolic_Enzyme_11_Gene_Sequence:
>867 bp
ATGGCCAGAGGACTCCAGGTTCCCCTGCCGCGGCTGGCCACAGGACTGCTGCTCCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCACTGATGGCAGCCCC
TGGCTCAGCATGCGGGAGGCCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCGGTGGTC
CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAAATTTTTCACCCTGACAGCCTAT
GCTGTTCCATGGACCCAGAAGGAATTTGATCGCGTTACGCTGGGCTACACTCAAGGGTTC
TTTGAAACAGAACATCTTCTGAAGAGATATTCTAGAAGTATGGCAATTATGAACAATGTA
TCTTTGGCCCTTCATAGGTGTTGTGTGGAGCTACTGCATAATGAGGCCCTGATCAGGCAC
CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGTGGGGCGGTG
CTGGCTAAGTACCTGTCGATTCCTGCTGTGTTTTTTTGGAGGTACATTCCATGTGACTTA
GACTTTAAGGGCACACAGTGTCCAAATCCTTCCTCCTATATTCCTAAGTTACTAACGACC
AATTCAGACCACATGACATTCCTGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACATTTGCCATACTTTTTCTGCCCCTTATGCAAGTCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATCTTGTCAGCTATGCATCCGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGACTACCCCAGGCCGATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACGGGAAGCCACTATCTCAG

# Metabolic_Enzyme_11_GenBank_ID_Gene:
M84128

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_11_Locus:
2q37

# Metabolic_Enzyme_11_SNPs:
Not Available

# Metabolic_Enzyme_11_General_References:
1898728; 1339448; 11434514; 1634050; 8280139; 8276413

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5728

# Metabolic_Enzyme_12_Name:
UDP-glucuronosyltransferase 1-3 precursor

# Metabolic_Enzyme_12_Synonyms:
UDP- glucuronosyltransferase 1A3; UDPGT; UGT1*3; UGT1-03; UGT1.3; UGT- 1C; UGT1C

# Metabolic_Enzyme_12_Gene_Name:
UGT1A3

# Metabolic_Enzyme_12_Protein_Sequence:
>UDPglucuronosyltransferase 13 precursor
MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVV
LTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNM
SLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDL
DFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQ
REVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_12_Number_of_Residues:
534

# Metabolic_Enzyme_12_Molecular_Weight:
60339

# Metabolic_Enzyme_12_Theoretical_pI:
8.28

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_12_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_12_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_12_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_12_Signals:
1-28

# Metabolic_Enzyme_12_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_12_GenBank_ID_Protein:
340135

# Metabolic_Enzyme_12_SwissProt_ID:
UD13_HUMAN (P35503)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
UGT1A3

# Metabolic_Enzyme_12_Geneatlas_id:
UGT1A3

# Metabolic_Enzyme_12_hgnc_id:
HGNC:12535

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Microsome

# Metabolic_Enzyme_12_Gene_Sequence:
>867 bp
ATGGCCACAGGACTCCAGGTTCCCCTGCCGTGGCTGGCCACAGGACTGCTGCTTCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCATTGATGGCAGCCAC
TGGCTCAGCATGCGGGAGGTCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCAGTGGTC
CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAACTTTTTCACCCTGACAACCTAT
GCCATTTCGTGGACCCAGGATGAATTTGATCGCCATGTGCTGGGCCACACTCAACTGTAC
TTTGAAACAGAACATTTTCTGAAGAAATTTTTCAGAAGTATGGCAATGTTGAACAATATG
TCTTTGGTCTATCATAGGTCTTGTGTGGAGCTACTACATAATGAGGCCCTGATCAGGCAC
CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGCGCGGCAGTG
CTGGCTAAGTACCTGTCGATTCCTACTGTGTTTTTTTTGAGGAACATTCCATGTGATTTA
GACTTTAAGGGCACACAGTGTCCAAACCCTTCCTCCTATATTCCTAGATTACTAACAACC
AATTCAGACCACATGACATTCATGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACATTTGCCATGCTTTTTCTGCTCCTTATGCAAGCCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATATTCTCAGTCATGCATCTGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGACTACCCCAGGCCAATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACAGGAAGCCACTATCTCAG

# Metabolic_Enzyme_12_GenBank_ID_Gene:
M84127

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_12_Locus:
2q37

# Metabolic_Enzyme_12_SNPs:
Not Available

# Metabolic_Enzyme_12_General_References:
1339448; 11434514

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5624

# Metabolic_Enzyme_13_Name:
Aldo-keto reductase family 1 member C2

# Metabolic_Enzyme_13_Synonyms:
Trans-1,2- dihydrobenzene-1,2-diol dehydrogenase; Type III 3- alpha-hydroxysteroid dehydrogenase; 3-alpha-HSD3; Chlordecone reductase homolog HAKRD; Dihydrodiol dehydrogenase/bile acid-binding protein; DD/BABP; Dihydrodiol dehydrogenase 2; DD2

# Metabolic_Enzyme_13_Gene_Name:
AKR1C2

# Metabolic_Enzyme_13_Protein_Sequence:
>Aldoketo reductase family 1 member C2
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
RNVRYLTLDIFAGPPNYPFSDEY

# Metabolic_Enzyme_13_Number_of_Residues:
323

# Metabolic_Enzyme_13_Molecular_Weight:
36736

# Metabolic_Enzyme_13_Theoretical_pI:
7.55

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Not Available

# Metabolic_Enzyme_13_Specific_Function:
Works in concert with the 5alpha/5beta-steroid reductases to convert steroid hormones into the 3alpha/5alpha and 3alpha/5beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5alpha-DHT) to 5-alpha-androstane-3alpha,17beta-diol (3-alpha-diol)

# Metabolic_Enzyme_13_Pathway:
Not Available

# Metabolic_Enzyme_13_Reaction:
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
None

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 1.3.1.20;EC 1.1.1.213

# Metabolic_Enzyme_13_GenBank_ID_Protein:
531160

# Metabolic_Enzyme_13_SwissProt_ID:
AK1C2_HUMAN (P52895)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
AKR1C2

# Metabolic_Enzyme_13_Geneatlas_id:
AKR1C2

# Metabolic_Enzyme_13_hgnc_id:
HGNC:385

# Metabolic_Enzyme_13_PDB_ID:
1IHI

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Cytoplasm (Potential)

# Metabolic_Enzyme_13_Gene_Sequence:
>972 bp
ATGGATTCGAAATACCAGTGTGTGAAGCTGAATGATGGTCACTTCATGCCTGTCCTGGGA
TTTGGCACCTATGCGCCTGCAGAGGTTCCTAAAAGTAAAGCTCTAGAGGCCGTCAAATTG
GCAATAGAAGCCGGGTTCCACCATATTGATTCTGCACATGTTTACAATAATGAGGAGCAG
GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTC
TACACTTCAAAGCTTTGGAGCAATTCCCATCGACCAGAGTTGGTCCGACCAGCCTTGGAA
AGGTCACTGAAAAATCTTCAATTGGACTATGTTGACCTCTATCTTATTCATTTTCCAGTG
TCTGTAAAGCCAGGTGAGGAAGTGATCCCAAAAGATGAAAATGGAAAAATACTATTTGAC
ACAGTGGATCTCTGTGCCACGTGGGAGGCCATGGAGAAGTGTAAAGATGCAGGATTGGCC
AAGTCCATCGGGGTGTCCAACTTCAACCACAGGCTGCTGGAGATGATCCTCAACAAGCCA
GGGCTCAAGTACAAGCCTGTCTGCAACCAGGTGGAATGTCATCCTTACTTCAACCAGAGA
AAACTGCTGGATTTCTGCAAGTCAAAAGACATTGTTCTGGTTGCCTATAGTGCTCTGGGA
TCCCATCGAGAAGAACCATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTC
CTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAG
CTGCAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAAC
GTGCAGGTGTTTGAATTCCAGTTGACTTCAGAGGAGATGAAAGCCATAGATGGCCTAAAC
AGAAATGTGCGATATTTGACCCTTGATATTTTTGCTGGCCCCCCTAATTATCCATTTTCT
GATGAATATTAA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
U05598

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_13_Locus:
10p15-p14

# Metabolic_Enzyme_13_SNPs:
rs2854482; rs3207909; rs1937863; rs1937855; rs4620617; rs7088486; rs12769178; rs3902926; rs7086564; rs1937865; rs4375350; rs10795218; rs1937868; rs1937856; rs2895050; rs7088509; rs7082231; rs1937892; rs7075514; rs1937889; rs1937867; rs2801886; rs4601669; rs2398174; rs7915365; rs7073591; rs7098927; rs2518040; rs1937870; rs1937860; rs10795221; rs7091798; rs2226258; rs1937854; rs2398175; rs11252885; rs1937866; rs2801885; rs11252879; rs1937890; rs7091942; rs7073715; rs12146227; rs7087112; rs7099721; rs10904388; rs1937861; rs4529810; rs7073878; rs11252884; rs1937853; rs1937862; rs7086573; rs10795220; rs1937891; rs12571988; rs1132229; rs4881375; rs2854494; rs2854466; rs2904806; rs2801891; rs9804390; rs2518045; rs9804392; rs10904387; rs3885233; rs3900662; rs2904812; rs4881372; rs4344395; rs11819128; rs2275929; rs2801926; rs3885232; rs9732372; rs2801897; rs2801893; rs1937872; rs2854491; rs11819348; rs11252869; rs10904385; rs2518039; rs2518044; rs10904384; rs12764498; rs10904386; rs2854467; rs2997319; rs2904807; rs11252876; rs1937873; rs11812106; rs12355347; rs4300311; rs2854490; rs2801895; rs7912100; rs3927920; rs11252870; rs2801896; rs2904808; rs11816204; rs9733478; rs1937888; rs10904383; rs1937884; rs1937886; rs10618; rs3207898; rs2518042; rs13933; rs3207901; rs3207905; rs2854486; rs2518043; rs8493; rs13945; rs3207904; rs13840; rs3207903; rs17846645; rs8314; rs41316041; rs2854468; rs7069541; rs2854469; rs2398165; rs28488494; rs12784525; rs2398172; rs2398170; rs1937859; rs11252882; rs2398177; rs2895048; rs2895051; rs12782334; rs35322662; rs4363495; rs1138743; rs36026148; rs28590375; rs34805072; rs1937857; rs3020658; rs11252880; rs2398169; rs3020659; rs28594873; rs2398166; rs1138738; rs1937852; rs2895052; rs11252883; rs2895045; rs1138758; rs2895049; rs2398164; rs2801884; rs35454481; rs35486838; rs1937851; rs2854479; rs1937871; rs28711900; rs12782301; rs3902925; rs4472836; rs12784556; rs2398173; rs2398176; rs28613695; rs1937858; rs7082227; rs35264282; rs7085982; rs28567035; rs2398171; rs3020660; rs1138741; rs11252881; rs2398178; rs3020657; rs10904389; rs2895047; rs11252878; rs2398163; rs35166812; rs3020656; rs2895046; rs1138759; rs35722966; rs2518041; rs2895053; rs10904390; rs4529809; rs10692238; rs2398168; rs2515679; rs1138745; rs6601877; rs2398167; rs28651095; rs1937869; rs2801928; rs36076403; rs11252875; rs2854478; rs34515072; rs3926326; rs2904811; rs3020668; rs2854472; rs12267144; rs34792441; rs2997315; rs3926325; rs11380937; rs2854474; rs35979147; rs11252871; rs12357650; rs11812357; rs2854492; rs2997320; rs34747355; rs11813483; rs34612007; rs41304583; rs2854476; rs2854481; rs4307630; rs2997321; rs2801887; rs12258087; rs11819572; rs34776622; rs2490065; rs11252873; rs3020664; rs34448751; rs2997323; rs2997314; rs3020666; rs2904809; rs2854487; rs11813470; rs2854484; rs2854485; rs5782796; rs3020667; rs7902108; rs2997322; rs11818926; rs2801927; rs2518038; rs10643636; rs2854473; rs7896657; rs2854477; rs11252872; rs2854480; rs2854489; rs2904810; rs2997318; rs2801892; rs2801929; rs12772460; rs41313802; rs2854475; rs2997324; rs41304573; rs2854488; rs2997316; rs2518034; rs2854493; rs4492708; rs3020665; rs34371823; rs7092546; rs41313806; rs11819371; rs35767584; rs34716664; rs11252874; rs28571848; rs11517324; rs1937887; rs34907157; rs10710137; rs11252866; rs28568332; rs34040160; rs12253443; rs12252183; rs11252864; rs11252887; rs11252889; rs12411321; rs12570475; rs17134158; rs2398193; rs4143630; rs4143631; rs6601887; rs6601888; rs7068923; rs7909151; rs7915338

# Metabolic_Enzyme_13_General_References:
8011662; 8274401; 7959017; 9716498; 10672042

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5725

# Metabolic_Enzyme_14_Name:
UDP-glucuronosyltransferase 1-1 precursor

# Metabolic_Enzyme_14_Synonyms:
UDP- glucuronosyltransferase 1A1; UDPGT; UGT1*1; UGT1-01; UGT1.1; UGT- 1A; UGT1A; Bilirubin-specific UDPGT isozyme 1; HUG-BR1

# Metabolic_Enzyme_14_Gene_Name:
UGT1A1

# Metabolic_Enzyme_14_Protein_Sequence:
>UDPglucuronosyltransferase 11 precursor
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_14_Number_of_Residues:
533

# Metabolic_Enzyme_14_Molecular_Weight:
59592

# Metabolic_Enzyme_14_Theoretical_pI:
8.09

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

# Metabolic_Enzyme_14_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_14_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_14_Signals:
1-25

# Metabolic_Enzyme_14_Transmembrane_Regions:
491-507

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_14_GenBank_ID_Protein:
184473

# Metabolic_Enzyme_14_SwissProt_ID:
UD11_HUMAN (P22309)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
UGT1A1

# Metabolic_Enzyme_14_Geneatlas_id:
UGT1A1

# Metabolic_Enzyme_14_hgnc_id:
HGNC:12530

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Microsome

# Metabolic_Enzyme_14_Gene_Sequence:
>1602 bp
ATGGCTGTGGAGTCCCAGGGCGGACGCCCACTTGTCCTGGGCCTGCTGCTGTGTGTGCTG
GGCCCAGTGGTGTCCCATGCTGGGAAGATACTGTTGATCCCAGTGGATGGCAGCCACTGG
CTGAGCATGCTTGGGGCCATCCAGCAGCTGCAGCAGAGGGGACATGAAATAGTTGTCCTA
GCACCTGACGCCTCGTTGTACATCAGAGACGGAGCATTTTACACCTTGAAGACGTACCCT
GTGCCATTCCAAAGGGAGGATGTGAAAGAGTCTTTTGTTAGTCTCGGGCATAATGTTTTT
GAGAATGATTCTTTCCTGCAGCGTGTGATCAAAACATACAAGAAAATAAAAAAGGACTCT
GCTATGCTTTTGTCTGGCTGTTCCCACTTACTGCACAACAAGGAGCTCATGGCCTCCCTG
GCAGAAAGCAGCTTTGATGTCATGCTGACGGACCCTTTCCTTCCTTGCAGCCCCATCGTG
GCCCAGTACCTGTCTCTGCCCACTGTATTCTTCTTGCATGCACTGCCATGCAGCCTGGAA
TTTGAGGCTACCCAGTGCCCCAACCCATTCTCCTACGTGCCCAGGCCTCTCTCCTCTCAT
TCAGATCACATGACCTTCCTGCAGCGGGTGAAGAACATGCTCATTGCCTTTTCACAGAAC
TTTCTGTGCGACGTGGTTTATTCCCCGTATGCAACCCTTGCCTCAGAATTCCTTCAGAGA
GAGGTGACTGTCCAGGACCTATTGAGCTCTGCATCTGTCTGGCTGTTTAGAAGTGACTTT
GTGAAGGATTACCCTAGGCCCATCATGCCCAATATGGTTTTTGTTGGTGGAATCAACTGC
CTTCACCAAAATCCACTATCCCAGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACAT
GGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATG
GCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACC
CGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTG
CTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAA
AGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAAT
GCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCT
GAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATC
ATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTC
TGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGAC
CTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTG
ACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAA
AAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_14_GenBank_ID_Gene:
M57899

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_14_Locus:
2q37

# Metabolic_Enzyme_14_SNPs:
Not Available

# Metabolic_Enzyme_14_General_References:
1898728; 1339448; 11434514; 1634050; 8280139; 8276413; 8226884; 7989045; 7989595; 7715297; 9621515; 9627603

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5741

# Metabolic_Enzyme_15_Name:
UDP-glucuronosyltransferase 1-7 precursor

# Metabolic_Enzyme_15_Synonyms:
UDP- glucuronosyltransferase 1A7; UDPGT; UGT1*7; UGT1-07; UGT1.7; UGT- 1G; UGT1G

# Metabolic_Enzyme_15_Gene_Name:
UGT1A7

# Metabolic_Enzyme_15_Protein_Sequence:
>UDPglucuronosyltransferase 17 precursor
MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLF
FSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEG
AQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_15_Number_of_Residues:
530

# Metabolic_Enzyme_15_Molecular_Weight:
59819

# Metabolic_Enzyme_15_Theoretical_pI:
7.85

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_15_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_15_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_15_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_15_Signals:
1-25

# Metabolic_Enzyme_15_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_15_GenBank_ID_Protein:
2039360

# Metabolic_Enzyme_15_SwissProt_ID:
UD17_HUMAN (Q9HAW7)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
UGT1A7

# Metabolic_Enzyme_15_Geneatlas_id:
UGT1A7

# Metabolic_Enzyme_15_hgnc_id:
HGNC:12539

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Microsome

# Metabolic_Enzyme_15_Gene_Sequence:
>1593 bp
ATGGCTCGTGCAGGGTGGACTGGCCTCCTTCCCCTATATGTGTGTCTACTGCTGACCTGT
GGCTTTGCCAAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGCCACTGGTTCACC
ATGCAGTCGGTGGTGGAGAAACTCATCCTCAGGGGGCATGAGGTGGTCGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGGAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCA
TACACTCTGGAGGATCAGGACCGGGAGTTCATGGTTTTTGCCGATGCTCGCTGGACGGCA
CCATTGCGAAGTGCATTTTCTCTATTAACAAGTTCATCCAATGGTATTTTTGACTTATTT
TTTTCAAATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGT
TGTTTTGATGCAGTGTTTCTCGATCCTTTTGATGCCTGTGGCTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCGCCAGGGGAATATTTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGACTTCTCTTAGGGTTCTCAGACGCC
ATGACTTTCAAGGAGAGAGTATGGAACCACATCATGCACTTGGAGGAACATTTATTTTGC
CCCTATTTTTTCAAAAATGTCTTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACTGACTTTGTTTTGGAG
TATCCCAAACCCGTGATGCCCAATATGATCTTCATTGGTGGTATCAACTGTCATCAGGGA
AAGCCAGTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGCTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTTCAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
U89507

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_15_Locus:
2q37

# Metabolic_Enzyme_15_SNPs:
Not Available

# Metabolic_Enzyme_15_General_References:
9271343; 11434514; 11037804

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5721

# Metabolic_Enzyme_16_Name:
UDP-glucuronosyltransferase 2B7 precursor

# Metabolic_Enzyme_16_Synonyms:
UDPGT; 3,4- catechol estrogen specific; UDPGTh-2

# Metabolic_Enzyme_16_Gene_Name:
UGT2B7

# Metabolic_Enzyme_16_Protein_Sequence:
>UDPglucuronosyltransferase 2B7 precursor
MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSA
SILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFG
DITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTF
EKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVL
GRPTTLSETMGKADVWLIRNSWNFQFPHPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSG
ENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTM
SSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND

# Metabolic_Enzyme_16_Number_of_Residues:
529

# Metabolic_Enzyme_16_Molecular_Weight:
60695

# Metabolic_Enzyme_16_Theoretical_pI:
8.45

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_16_Specific_Function:
Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites

# Metabolic_Enzyme_16_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_16_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_16_Signals:
1-23

# Metabolic_Enzyme_16_Transmembrane_Regions:
493-509

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_16_GenBank_ID_Protein:
340080

# Metabolic_Enzyme_16_SwissProt_ID:
UDB7_HUMAN (P16662)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
UGT2B7

# Metabolic_Enzyme_16_Geneatlas_id:
UGT2B7

# Metabolic_Enzyme_16_hgnc_id:
HGNC:12554

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Microsome

# Metabolic_Enzyme_16_Gene_Sequence:
>1590 bp
ATGTCTGTGAAATGGACTTCAGTAATTTTGCTAATACAACTGAGCTTTTGCTTTAGCTCT
GGGAATTGTGGAAAGGTGCTGGTGTGGGCAGCAGAATACAGCCATTGGATGAATATAAAG
ACAATCCTGGATGAGCTTATTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAACAACTCATCCGCTCTTAAAATTGAAATTTATCCCACATCT
TTAACTAAAACTGAGTTGGAGAATTTCATCATGCAACAGATTAAGAGATGGTCAGACCTT
CCAAAAGATACATTTTGGTTATATTTTTCACAAGTACAGGAAATCATGTCAATATTTGGT
GACATAACTAGAAAGTTCTGTAAAGATGTAGTTTCAAATAAGAAATTTATGAAAAAAGTA
CAAGAGTCAAGATTTGACGTCATTTTTGCAGATGCTATTTTTCCCTGTAGTGAGCTGCTG
GCTGAGCTATTTAACATACCCTTTGTGTACAGTCTCAGCTTCTCTCCTGGCTACACTTTT
GAAAAGCATAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAGAA
TTAACTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTACTTT
GACTTTTGGTTCGAAATATTTGACATGAAGAAGTGGGATCAGTTTTATAGTGAAGTTCTA
GGAAGACCCACTACGTTATCTGAGACAATGGGGAAAGCTGACGTATGGCTTATTCGAAAC
TCCTGGAATTTTCAGTTTCCTCATCCACTCTTACCAAATGTTGATTTTGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTGCCTAAGGAAATGGAAGACTTTGTACAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGG
GCCAACGTAATTGCATCAGCCCTGGCCCAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATACCTTAGGTCTCAATACTCGGCTGTATAAGTGGATACCCCAGAAT
GACCTTCTAGGTCATCCAAAGACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TACGAGGCAATCTACCATGGGATCCCTATGGTGGGGATTCCATTGTTTGCCGATCAACCT
GATAACATTGCTCACATGAAGGCCAGGGGAGCAGCTGTTAGAGTGGACTTCAACACAATG
TCGAGTACAGACTTGCTGAATGCATTGAAGAGAGTAATTAATGATCCTTCATATAAAGAG
AATGTTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCTAAACACCTTCGGGTTGCAGCC
CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGTCTGT
GTGGCAACTGTGATATTTATCGTCACAAAATGTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGCAAAGAAGGGAAAAAATGATTAG

# Metabolic_Enzyme_16_GenBank_ID_Gene:
J05428

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_16_Locus:
4q13

# Metabolic_Enzyme_16_SNPs:
rs7439366; rs12233719; rs35590824; rs7438284; rs4348159; rs4292394; rs28365062; rs5013211; rs7686056; rs6600884; rs7441750; rs7439152; rs12513195; rs4293848; rs3924192; rs7442453; rs7698846; rs7678656; rs12506962; rs7441774; rs6600888; rs6858558; rs6600885; rs6600891; rs7375178; rs7435335; rs6600890; rs6600887; rs7438244; rs4521414; rs6600889; rs12647682; rs7434332; rs12508257; rs4694628; rs6600886; rs4314347; rs12647681; rs7439326; rs7698645; rs12512526; rs10028494; rs9995928; rs3924194; rs6600892; rs4364327; rs3924193; rs12642938; rs4337789; rs7679184; rs12648462; rs10050146; rs4257713; rs4588522; rs4356975; rs7693957; rs7658752; rs4314345; rs7438942; rs4351080; rs4541594; rs10006452; rs6851533; rs6600880; rs7438135; rs11940316; rs6600879; rs7668282; rs7668258; rs4538548; rs6600883; rs6600893; rs7662029; rs4455491; rs11940220; rs4554144; rs5859163; rs34620993; rs34851008; rs34308305; rs34661811; rs35327868; rs35893826; rs10022440; rs13136922; rs34407256; rs35452834; rs34095769; rs5859161; rs34241812; rs34302283; rs34386959; rs35475910; rs34561399; rs28675300; rs34556519; rs28673873; rs35185848; rs28539948; rs34571475; rs34318523; rs35402056; rs5859162; rs34182209; rs4694177; rs28375964; rs35605246; rs11302069; rs10008743; rs5859160; rs4356974; rs34630750; rs7437605; rs6819882; rs34590280; rs11249527; rs11249528; rs12506592; rs13118991; rs13135225; rs28365063; rs4274916; rs4358465; rs4434330; rs4535394; rs4694169; rs6422323; rs6422324; rs6600876; rs6843382; rs7437174; rs7657423; rs7676472

# Metabolic_Enzyme_16_General_References:
2159463; 11186130

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5303

# Metabolic_Enzyme_17_Name:
Aldo-keto reductase family 1 member C4

# Metabolic_Enzyme_17_Synonyms:
Chlordecone reductase; CDR; 3-alpha-hydroxysteroid dehydrogenase type I; 3-alpha-HSD1; Dihydrodiol dehydrogenase 4; DD4; HAKRA

# Metabolic_Enzyme_17_Gene_Name:
AKR1C4

# Metabolic_Enzyme_17_Protein_Sequence:
>Aldoketo reductase family 1 member C4
MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP
GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
RNYRYVVMDFLMDHPDYPFSDEY

# Metabolic_Enzyme_17_Number_of_Residues:
323

# Metabolic_Enzyme_17_Molecular_Weight:
37095

# Metabolic_Enzyme_17_Theoretical_pI:
7.19

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Not Available

# Metabolic_Enzyme_17_Specific_Function:
Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3alpha,17beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route

# Metabolic_Enzyme_17_Pathway:
map00120  Bile acid biosynthesis;
 map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_17_Reaction:
chlordecone alcohol + NADP+ = chlordecone + NADPH + H+

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_17_Signals:
None

# Metabolic_Enzyme_17_Transmembrane_Regions:
None

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 1.1.1.225;EC 1.1.1.50

# Metabolic_Enzyme_17_GenBank_ID_Protein:
4261710

# Metabolic_Enzyme_17_SwissProt_ID:
AK1C4_HUMAN (P17516)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
AKR1C4

# Metabolic_Enzyme_17_Geneatlas_id:
AKR1C4

# Metabolic_Enzyme_17_hgnc_id:
HGNC:387

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_17_Gene_Sequence:
>972 bp
ATGGATCCCAAATATCAGCGTGTAGAGCTAAATGATGGTCATTTCATGCCCGTATTGGGA
TTTGGCACCTATGCACCTCCAGAGGTTCCGAGGAACAGAGCTGTAGAGGTCACCAAATTA
GCAATAGAAGCTGGCTTCCGCCATATTGATTCTGCTTATTTATACAATAATGAGGAGCAG
GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTC
TACACTTCAAAGCTTTGGTGCACTTTCTTTCAACCACAGATGGTCCAACCAGCCTTGGAA
AGCTCACTGAAAAAACTTCAACTGGACTATGTTGACCTCTATCTTCTTCATTTCCCAATG
GCTCTCAAGCCAGGTGAGACGCCACTACCAAAAGATGAAAATGGAAAAGTAATATTCGAC
ACAGTGGATCTCTCTGCCACATGGGAGGTCATGGAGAAGTGTAAGGATGCAGGATTGGCC
AAGTCCATCGGGGTGTCAAACTTCAACTGCAGGCAGCTGGAGATGATCCTCAACAAGCCA
GGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCTTACCTCAACCAGAGC
AAACTGCTGGATTTCTGCAAGTCAAAAGACATTGTTCTGGTTGCCCACAGTGCTCTGGGA
ACCCAACGACATAAACTATGGGTGGACCCAAACTCCCCAGTTCTTTTGGAGGACCCAGTT
CTTTGTGCCTTAGCAAAGAAACACAAACGAACCCCAGCCCTGATTGCCCTGCGCTACCAG
CTGCAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGGATCAGAGAGAAC
ATCCAGGTTTTTGAATTCCAGTTGACATCAGAGGATATGAAAGTTCTAGATGGTCTAAAC
AGAAATTATCGATATGTTGTCATGGATTTTCTTATGGACCATCCTGATTATCCATTTTCA
GATGAATATTAG

# Metabolic_Enzyme_17_GenBank_ID_Gene:
S68287

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_17_Locus:
10p15-p14

# Metabolic_Enzyme_17_SNPs:
rs3829125; rs17134592; rs11253043; rs17306779; rs2398157; rs17307359; rs1413622; rs10458795; rs1931679; rs7085249; rs1413781; rs1413624; rs2050308; rs7921838; rs7088788; rs6601927; rs4881412; rs6601924; rs7078211; rs12247748; rs11594448; rs7101071; rs17134526; rs7092102; rs3750572; rs10795255; rs3750569; rs12762017; rs1413780; rs2225695; rs3750567; rs7070862; rs1832007; rs10904440; rs10795256; rs3750568; rs3750571; rs7074004; rs1889457; rs4881413; rs7475281; rs7908297; rs11253046; rs7475279; rs17134531; rs7083869; rs7897431; rs1334475; rs2151896; rs7087111; rs17134533; rs1334474; rs11594520; rs12257364; rs17134589; rs4881411; rs11594428; rs4098025; rs17134585; rs11253045; rs7477230; rs17134523; rs34463109; rs34030369; rs11253042; rs7100517; rs12771394; rs1831977; rs11253041; rs2398160; rs1334473; rs2210681; rs7477114; rs7893850; rs36048054; rs11596429; rs3996505; rs7099303; rs4478889; rs4427472; rs11253047; rs2095367; rs12264733; rs7099651; rs2050309; rs4612705; rs35950499; rs17134588; rs12252186; rs4880716; rs6601928; rs7072596; rs17134601; rs11253048; rs17134604; rs4880718; rs17851824; rs3038974; rs1413623; rs35960357; rs11327365; rs11268534; rs2398158; rs3039101; rs7096122; rs3750570; rs2398159; rs5782814; rs11253044; rs35917693; rs10600924; rs9423555; rs4350268; rs7909380; rs10586998; rs7915357; rs41305665; rs4420164; rs4424574; rs5782812; rs4642979; rs915135; rs34826816; rs12784055; rs3039090; rs35154936; rs2151895; rs35283379; rs1334472; rs7912751; rs7909379; rs2104997; rs5782813; rs12776936; rs2065661; rs10458789; rs34351269; rs11253040; rs1811960; rs3812617; rs11402533; rs12774775; rs10711188; rs11291778; rs11427518; rs3841204; rs3812616; rs10795253; rs10904441; rs10904442; rs11253038; rs12253078; rs12267307; rs12269559; rs12360316; rs12775790; rs1334466; rs17134607; rs17134608; rs17134610; rs17134614; rs17134616; rs17134617; rs17155741; rs17306485; rs1889456; rs1931681; rs2151901; rs6422393; rs6601929; rs7091223; rs7096360; rs9423382

# Metabolic_Enzyme_17_General_References:
8274401; 7650035; 7626489; 10634139; 10672042; 11158055; 2187532; 8172617; 1530633

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5733

# Metabolic_Enzyme_18_Name:
UDP-glucuronosyltransferase 1-5 precursor

# Metabolic_Enzyme_18_Synonyms:
UDP- glucuronosyltransferase 1A5; UDPGT; UGT1*5; UGT1-05; UGT1.5; UGT- 1E; UGT1E

# Metabolic_Enzyme_18_Gene_Name:
UGT1A5

# Metabolic_Enzyme_18_Protein_Sequence:
>UDPglucuronosyltransferase 15 precursor
MATGLQVPLPQLATGLLLLLSVQPWAESGKVLVVPTDGSHWLSMREALRDLHARGHQVVV
LTLEVNMYIKEENFFTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNM
SLIIHRSCVELLHNEALIRHLHATSFDVVLTDPFHLCAAVLAKYLSIPAVFFLRNIPCDL
DFKGTQCPNPSSYIPRLLTTNSDHMTFLQRVKNMLYPLALSYLCHAVSAPYASLASELFQ
REVSVVDLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_18_Number_of_Residues:
534

# Metabolic_Enzyme_18_Molecular_Weight:
60072

# Metabolic_Enzyme_18_Theoretical_pI:
8.14

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_18_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_18_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_18_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_18_Signals:
1-28

# Metabolic_Enzyme_18_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_18_GenBank_ID_Protein:
340139

# Metabolic_Enzyme_18_SwissProt_ID:
UD15_HUMAN (P35504)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
UGT1A5

# Metabolic_Enzyme_18_Geneatlas_id:
UGT1A5

# Metabolic_Enzyme_18_hgnc_id:
HGNC:12537

# Metabolic_Enzyme_18_PDB_ID:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Microsome

# Metabolic_Enzyme_18_Gene_Sequence:
>867 bp
ATGGCCACAGGACTCCAGGTTCCCCTGCCGCAGCTGGCCACAGGACTGCTGCTTCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGGAAGGTGCTGGTGGTGCCCACTGATGGCAGCCAC
TGGCTCAGCATGCGGGAGGCCTTGCGGGACCTCCATGCGAGAGGCCACCAGGTGGTGGTC
CTCACCCTGGAGGTGAATATGTACATCAAAGAAGAGAACTTTTTCACCCTGACAACGTAT
GCCATTTCATGGACCCAGGACGAATTTGATCGCCTTTTGCTGGGTCACACTCAATCGTTC
TTTGAAACAGAACATCTTCTGATGAAATTTTCTAGAAGAATGGCAATTATGAACAATATG
TCTTTGATCATACATAGGTCTTGTGTGGAGCTACTGCATAATGAGGCCCTGATCAGGCAC
CTGCATGCTACTTCCTTTGATGTGGTTCTAACAGACCCCTTTCACCTCTGCGCGGCGGTG
CTGGCTAAGTACCTGTCGATTCCTGCTGTGTTTTTCTTGAGGAACATTCCATGTGATTTA
GACTTTAAGGGCACACAGTGTCCAAACCCTTCCTCCTATATTCCTAGATTACTAACGACC
AATTCAGACCACATGACATTCCTGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACCTTTGCCATGCTGTTTCTGCTCCTTATGCAAGCCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATCTTGTCAGCCATGCATCTGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGATTACCCCAGGCCGATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACGGGAAGCCACTATCTCAG

# Metabolic_Enzyme_18_GenBank_ID_Gene:
M84129

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_18_Locus:
2q37

# Metabolic_Enzyme_18_SNPs:
Not Available

# Metabolic_Enzyme_18_General_References:
1339448; 11434514

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5724

# Metabolic_Enzyme_19_Name:
UDP-glucuronosyltransferase 2A1 precursor

# Metabolic_Enzyme_19_Synonyms:
Not Available

# Metabolic_Enzyme_19_Gene_Name:
UGT2A1

# Metabolic_Enzyme_19_Protein_Sequence:
>UDPglucuronosyltransferase 2A1 precursor
MLNNLLLFSLQISLIGTTLGGNVLIWPMEGSHWLNVKIIIDELIKKEHNVTVLVASGALF
ITPTSNPSLTFEIYKVPFGKERIEGVIKDFVSTWLENRPSPSTIWRFYQEMAKVIKDFHM
VSQEICDGVLKNQQLMAKLKKSKFEVLVSDPVFPCGDIVALKLGIPFMYSLRFSPASTVE
KHCGKVPYPPSYVPAVLSELTDQMSFTDRIRNFISYHLQDYMFETLWKSWDSYYSKALGR
PTTLCETMGKAEIWLIRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFIQSSGKN
GVVVFSLGSMVKNLTEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDL
LGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTS
VDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHD
LTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKFGKIGKKKKRE

# Metabolic_Enzyme_19_Number_of_Residues:
527

# Metabolic_Enzyme_19_Molecular_Weight:
59873

# Metabolic_Enzyme_19_Theoretical_pI:
9.29

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_19_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform is active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium

# Metabolic_Enzyme_19_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_19_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_19_Signals:
1-20

# Metabolic_Enzyme_19_Transmembrane_Regions:
491-507

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_19_GenBank_ID_Protein:
4753766

# Metabolic_Enzyme_19_SwissProt_ID:
UDA1_HUMAN (Q9Y4X1)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
UGT2A1

# Metabolic_Enzyme_19_Geneatlas_id:
UGT2A1

# Metabolic_Enzyme_19_hgnc_id:
HGNC:12542

# Metabolic_Enzyme_19_PDB_ID:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Membrane

# Metabolic_Enzyme_19_Gene_Sequence:
>1584 bp
ATGTTAAACAACCTTCTGCTGTTCTCCCTTCAGATAAGTCTCATAGGAACCACTCTTGGT
GGGAATGTTTTGATTTGGCCAATGGAAGGTAGTCATTGGCTAAATGTTAAGATAATTATA
GATGAGCTCATTAAAAAGGAGCATAATGTGACTGTCCTAGTTGCCTCTGGTGCACTTTTC
ATCACACCAACCTCTAACCCATCTCTGACATTTGAAATATATAAGGTGCCCTTTGGCAAA
GAAAGAATAGAAGGAGTAATTAAGGACTTCGTTTCGACATGGCTGGAAAATAGACCATCT
CCTTCAACCATTTGGAGATTCTATCAGGAGATGGCCAAAGTAATCAAGGACTTCCACATG
GTGTCTCAGGAGATCTGTGATGGCGTTCTTAAAAACCAACAGCTGATGGCAAAGCTAAAG
AAAAGCAAGTTTGAAGTCCTGGTGTCTGATCCAGTATTTCCTTGTGGCGATATAGTAGCT
TTAAAACTTGGAATTCCATTTATGTACTCCTTGAGGTTTTCTCCAGCCTCAACAGTGGAA
AAGCACTGTGGGAAGGTACCATACCCTCCTTCCTATGTTCCTGCTGTTTTATCAGAACTC
ACCGACCAAATGTCTTTCACTGACAGAATAAGAAATTTCATCTCCTACCACCTACAGGAC
TACATGTTTGAAACTCTTTGGAAATCATGGGATTCATACTATAGTAAAGCTTTAGGAAGA
CCCACTACGTTATGTGAGACTATGGGGAAAGCTGAAATTTGGTTAATCCGAACATATTGG
GATTTTGAATTTCCTCGTCCATACTTACCTAATTTTGAGTTTGTTGGAGGATTGCACTGC
AAACCTGCCAAACCTTTACCTAAGGAAATGGAAGAATTTATCCAGAGCTCAGGTAAAAAT
GGTGTTGTGGTGTTTTCTCTGGGATCAATGGTCAAAAACCTTACAGAAGAAAAGGCCAAT
CTTATTGCCTCAGCCCTTGCCCAGATTCCACAGAAGGTTTTATGGAGATACAAAGGAAAG
AAACCAGCCACATTAGGAAACAATACTCAGCTCTTTGATTGGATACCCCAGAATGATCTT
CTTGGACATCCCAAAACCAAAGCTTTTATCACTCATGGTGGAACTAATGGGATCTACGAA
GCTATTTACCACGGAGTCCCTATGGTGGGAGTTCCCATGTTTGCTGATCAGCCTGATAAC
ATTGCTCACATGAAGGCCAAAGGAGCAGCTGTGGAAGTGAACCTAAACACAATGACAAGT
GTGGATTTGCTTAGCGCTTTGAGAACAGTCATTAATGAACCTTCTTATAAAGAGAATGCT
ATGAGGTTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTGGATCGAGCAGTCTTC
TGGATCGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTTCGGGTTGCAGCCCATGAC
CTCACCTGGTTCCAGTACCACTCTTTGGATGTAATTGGGTTCTTGCTGGTCTGTGTGACA
ACGGCTATATTTTTGGTCATACAATGTTGTTTGTTTTCCTGTCAAAAATTTGGTAAGATA
GGAAAGAAGAAAAAAAGAGAATAG

# Metabolic_Enzyme_19_GenBank_ID_Gene:
AJ006054

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_19_Locus:
4q13

# Metabolic_Enzyme_19_SNPs:
rs4148301; rs4148304; rs2163659; rs7668703; rs1432329; rs1432332; rs7659937; rs7672805; rs979363; rs10000435; rs4148279; rs10028495; rs7656541; rs6835972; rs4148276; rs1432330; rs4148277; rs6600796; rs1821185; rs1432335; rs1432336; rs1319811; rs7671313; rs10903210; rs7689493; rs10013528; rs9992698; rs988671; rs6842466; rs6825253; rs4148291; rs11728546; rs2331685; rs2017370; rs4694225; rs6832424; rs6600793; rs1432324; rs1560605; rs2163658; rs4148308; rs4401516; rs6600794; rs988672; rs3775783; rs1036160; rs7655867; rs6854350; rs1835826; rs4148295; rs2288740; rs2288741; rs1438537; rs1432316; rs6853543; rs11249451; rs1158439; rs4148281; rs10001991; rs11946382; rs10518063; rs2033798; rs6600792; rs4048747; rs1432314; rs10033801; rs7676249; rs10026988; rs10028954; rs7662867; rs1432315; rs11249452; rs1835821; rs10006049; rs4148289; rs10011630; rs7662309; rs4148298; rs10021575; rs17147507; rs9999694; rs6846404; rs4694219; rs17147542; rs7692074; rs10023821; rs11933160; rs7662915; rs1967984; rs6855271; rs4148292; rs11249454; rs10033879; rs1432313; rs7685874; rs17147532; rs7665571; rs11736315; rs4473712; rs10023782; rs4694222; rs7670819; rs7699881; rs6824954; rs11936310; rs11936130; rs6600795; rs1432327; rs10011912; rs3822178; rs1835829; rs9999430; rs6848997; rs1835822; rs11942157; rs4148290; rs17674565; rs17674511; rs10004306; rs6811810; rs4148297; rs17618404; rs1583243; rs6858314; rs10012508; rs6832784; rs2217587; rs3775782; rs12507278; rs6855294; rs17147530; rs11731188; rs10009530; rs6824830; rs13129549; rs6831807; rs11736373; rs10006483; rs17618520; rs17680131; rs7680856; rs4148286; rs11931365; rs10023877; rs17618178; rs11722780; rs10027493; rs6826237; rs17147521; rs11249453; rs7688383; rs4148299; rs4148302; rs9997689; rs6814603; rs7681367; rs17674648; rs9917881; rs4148296; rs11721934; rs4148283; rs6849110; rs12501520; rs4148307; rs11736353; rs13120401; rs4550998; rs4148309; rs6839067; rs6852329; rs7670238; rs7668967; rs11946584; rs10022954; rs6832167; rs2010207; rs12500392; rs7690649; rs17617467; rs10013712; rs9993182; rs6846030; rs4148305; rs17618230; rs10026603; rs4694027; rs4148288; rs6831951; rs11730451; rs10005934; rs1897441; rs4395582; rs11729544; rs4148312; rs4280808; rs10518065; rs11929943; rs11929908; rs10033854; rs17147557; rs1550292; rs13134357; rs11939884; rs1432334; rs1432333; rs17619211; rs17681080; rs10471252; rs1347046; rs41292307; rs4148310; rs41292305; rs35926238; rs4148275; rs7674020; rs35816431; rs34251717; rs11438429; rs4148311; rs4694226; rs1368116; rs35378505; rs34607614; rs4148278; rs10649712; rs10682826; rs188964; rs11732515; rs192970; rs11725441; rs28448316; rs33924396; rs28798793; rs17147492; rs324309; rs28413749; rs17147503; rs17147534; rs28404221; rs6600791; rs28570072; rs33943659; rs34090224; rs35971542; rs11460578; rs33999522; rs11441625; rs11323266; rs35281757; rs7677083; rs28776197; rs28782228; rs35910775; rs10583998; rs12644575; rs1967983; rs34446108; rs34142192; rs28544323; rs4148294; rs35582043; rs189787; rs4148285; rs11931171; rs2033801; rs11319385; rs11279957; rs5859193; rs324313; rs4148282; rs33938194; rs7377236; rs34704021; rs36106673; rs28818211; rs28532778; rs34265777; rs4148303; rs13119853; rs36003863; rs1583242; rs34513233; rs985040; rs7686386; rs10691812; rs34650072; rs13112999; rs11721725; rs28759827; rs28726183; rs34028035; rs324310; rs4409023; rs4148320; rs13131759; rs33953975; rs17147520; rs36051343; rs35795947; rs7672793; rs36163528; rs34021488; rs11733854; rs11721681; rs7669007; rs13149874; rs4148322; rs36083211; rs34789624; rs35333044; rs28560222; rs7693686; rs34698455; rs4148306; rs7657761; rs34909158; rs5859194; rs34670944; rs35243459; rs34139484; rs35400584; rs28689093; rs188966; rs11946796; rs11947056; rs11733907; rs28568390; rs34647023; rs10010846; rs6813494; rs7698372; rs28716091; rs10023818; rs35302832; rs34810925; rs34370025; rs4148313; rs4148287; rs34213902; rs35487350; rs35071017; rs10569499; rs33913173; rs28522985; rs34858243; rs28556671; rs34208726; rs34396917; rs4148284; rs11728785; rs28560191; rs28513556; rs28508252; rs36191379; rs4148316; rs4148280; rs4148293; rs7668214; rs2877457; rs34817437; rs2116564; rs11940905; rs10017134; rs28528833; rs35101874; rs33976214; rs34975164; rs34590689; rs34452487; rs2043241; rs3074345; rs35227598; rs34012364; rs34002846; rs28744454; rs34078716; rs34062331; rs5859195; rs35000204; rs33992705; rs10031145; rs33924614; rs11937993; rs13115454; rs1347047; rs1432317; rs1835830; rs4333255; rs6810459; rs7671030; rs7671041; rs7674562; rs7694939; rs9329029; rs9996459

# Metabolic_Enzyme_19_General_References:
10359671

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
5734

# Metabolic_Enzyme_20_Name:
UDP-glucuronosyltransferase 2B11 precursor

# Metabolic_Enzyme_20_Synonyms:
UDPGT

# Metabolic_Enzyme_20_Gene_Name:
UGT2B11

# Metabolic_Enzyme_20_Protein_Sequence:
>UDPglucuronosyltransferase 2B11 precursor
MTLKWTSVLLLIHLSCYFSSGSCGKVLVWAAEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDASTLKFEVYPTSLTKTEFENIIMQQVKRWSDIRKDSFWLYFSQEQEILWELY
DIFRNFCKDVVSNKKVMKKLQESRFDIVFADAVFPCGELLAALLNIRFVYSLRFTPGYTI
ERHSGGLIFPPSYIPIVMSKLSDQMTFMERVKNMIYVLYFDFWFQMSDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNVDFVGGFHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRLDFNTM
SSTDLLNALKTVINDPLYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMPHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLACVATVIFIITKFCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_20_Number_of_Residues:
529

# Metabolic_Enzyme_20_Molecular_Weight:
61039

# Metabolic_Enzyme_20_Theoretical_pI:
9.29

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_20_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_20_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_20_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_20_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_20_Signals:
1-21

# Metabolic_Enzyme_20_Transmembrane_Regions:
493-513

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_20_GenBank_ID_Protein:
3360273

# Metabolic_Enzyme_20_SwissProt_ID:
UDB11_HUMAN (O75310)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
UGT2B11

# Metabolic_Enzyme_20_Geneatlas_id:
UGT2B11

# Metabolic_Enzyme_20_hgnc_id:
HGNC:12545

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Microsome

# Metabolic_Enzyme_20_Gene_Sequence:
>1590 bp
ATGACTCTGAAATGGACTTCAGTTCTTCTGCTGATACATCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAAGTGCTGGTGTGGGCCGCAGAATACAGCCATTGGATGAATATGAAG
ACAATCCTGAAAGAGCTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAATGATGCATCCACTCTTAAATTTGAAGTTTATCCTACATCT
TTAACTAAAACTGAATTTGAGAATATCATCATGCAACAGGTTAAGAGATGGTCAGACATT
CGAAAAGATAGCTTTTGGTTATATTTTTCACAAGAACAAGAAATCCTGTGGGAATTATAT
GACATATTTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAAGTTATGAAAAAACTA
CAAGAGTCAAGATTTGACATCGTTTTTGCAGATGCTGTTTTTCCCTGTGGTGAGCTGCTG
GCTGCGCTACTTAACATACGGTTTGTGTACAGTCTCCGCTTTACTCCTGGCTACACAATT
GAAAGGCACAGTGGAGGACTGATTTTCCCTCCTTCCTACATACCTATTGTTATGTCAAAA
TTAAGTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTATTTT
GACTTTTGGTTCCAAATGTCTGATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTA
GGAAGACCCACTACCTTATTTGAGACAATGGGAAAAGCTGACATATGGCTTATGCGAAAC
TCCTGGAGTTTTCAATTTCCTCATCCATTCTTACCAAACGTTGATTTTGTTGGAGGATTC
CACTGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAGTTTGTACAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAGTGATAAGTAACATGACAGCAGAAAGG
GCCAATGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAC
GGGAATAAACCAGATGCCTTAGGTCTCAATACTCGGCTGTACAAGTGGATACCCCAGAAT
GACCTTCTAGGTCATCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATGAGGCAATCTACCATGGGATCCCTATGGTGGGCATTCCATTGTTTTTTGATCAACCT
GATAACATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGATTGGACTTCAACACAATG
TCGAGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTTATATAAAGAG
AATATTATGAAATTATCAAGAATTCAACATGATCAACCAGTAAAGCCCCTGGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCCCCACAAAGGAGCCAAACACCTTCGAGTTGCAGCC
CATGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTTCTGCTGGCCTGT
GTGGCAACTGTGATATTTATCATCACAAAGTTTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGGGAAGAAGGGAAAAAGAGATTAG

# Metabolic_Enzyme_20_GenBank_ID_Gene:
AF016492

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_20_Locus:
4q13.2

# Metabolic_Enzyme_20_SNPs:
rs4694697; rs4415023; rs4400059; rs4543201; rs4283741; rs11945946; rs7436729; rs11947293; rs4463131; rs6833028; rs12500268; rs4608875; rs7688262; rs7697037; rs3890590; rs7697482; rs35248576; rs11340393; rs5859168; rs4485863; rs28743034; rs4619960; rs13148581; rs13113479; rs4406085; rs34519957; rs13119196; rs28561592; rs4406086; rs13134572; rs7660257; rs13148525; rs35902951; rs13148376; rs4386666; rs13134364; rs13113695; rs4485864; rs13107183; rs7660248; rs13119170; rs13103028; rs13134363; rs35555504; rs13139597; rs35443238; rs28470680; rs13113271; rs13119197; rs13107219; rs10007587; rs4466107; rs10434518; rs34416320; rs10007579; rs6847476; rs10012181; rs9996390; rs12502502; rs13123057; rs4526045; rs4694199; rs6817250; rs6825376; rs7672567; rs7682460; rs7695331

# Metabolic_Enzyme_20_General_References:
9675083

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
5583

# Metabolic_Enzyme_21_Name:
Bile salt sulfotransferase

# Metabolic_Enzyme_21_Synonyms:
Hydroxysteroid Sulfotransferase; HST; Dehydroepiandrosterone sulfotransferase; DHEA-ST; ST2; ST2A3

# Metabolic_Enzyme_21_Gene_Name:
SULT2A1

# Metabolic_Enzyme_21_Protein_Sequence:
>Bile salt sulfotransferase
MSDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSK
GDAKWIQSVP
IWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYL
MRNPRDVLVSGYFFWKNMKFI
KKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKN
FLLLSYEELKQDTGRTIEKICQFLGKTLEPEE
LNLILKNSSFQSMKENKMSNYSLLSVD
YVVDKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRE
LFPWE

# Metabolic_Enzyme_21_Number_of_Residues:
285

# Metabolic_Enzyme_21_Molecular_Weight:
33780

# Metabolic_Enzyme_21_Theoretical_pI:
5.76

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Not Available

# Metabolic_Enzyme_21_Specific_Function:
Catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands

# Metabolic_Enzyme_21_Pathway:
Not Available

# Metabolic_Enzyme_21_Reaction:
3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_21_Signals:
None

# Metabolic_Enzyme_21_Transmembrane_Regions:
None

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 2.8.2.14

# Metabolic_Enzyme_21_GenBank_ID_Protein:
306702

# Metabolic_Enzyme_21_SwissProt_ID:
ST2A1_HUMAN (Q06520)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
SULT2A1

# Metabolic_Enzyme_21_Geneatlas_id:
SULT2A1

# Metabolic_Enzyme_21_hgnc_id:
HGNC:11458

# Metabolic_Enzyme_21_PDB_ID:
1OV4

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_21_Gene_Sequence:
>858 bp

ATGTCGGACGATTTCTTATGGTTTGAAGGCATAGCTTTCCCTACTATGGGTTTCAGATC
CGAAACCTTAA
GAAAAGTACGTGATGAGTTCGTGATAAGGGATGAAGATGTAATAATAT
TGACTTACCCCAAATCAGGAAC
AAACTGGTTGGCTGAGATTCTCTGCCTGATGCACTCC
AAGGGGGATGCCAAGTGGATCCAATCTGTGCCC
ATCTGGGAGCGATCACCCTGGGTAGA
GAGTGAGATTGGGTATACAGCACTCAGTGAAAGCGAGAGTCCAC
GTTTATTCTCCTCCC
ACCTCCCCATCCAGTTATTCCCCAAGTCTTTCTTCAGTTCCAAGGCCAAGGTGAT
TTAT
CTCATGAGAAATCCCAGAGATGTTTTGGTGTCTGGTTATTTTTTCTGGAAAAACATGAAG
TTTATT
AAGAAACCAAAGTCATGGGAAGAATATTTTGAATGGTTTTGTCAAGGAACTGT
GCTATATGGGTCATGGT
TTGACCACATTCATGGCTGGATGCCCATGAGAGAGGAGAAAA
ACTTCCTGTTACTGAGTTATGAGGAGCT
GAAACAGGACACAGGAAGAACCATAGAGAAG
ATCTGTCAATTCCTGGGAAAGACGTTAGAACCCGAAGAA
CTGAACTTAATTCTCAAGAA
CAGCTCCTTTCAGAGCATGAAAGAAAACAAGATGTCCAATTATTCCCTCC
TGAGTGTTG
ATTATGTAGTGGACAAAGCACAACTTCTGAGAAAAGGTGTATCTGGGGACTGGAAAAATC
A
CTTCACAGTGGCCCAAGCTGAAGACTTTGATAAATTGTTCCAAGAGAAGATGGCAGAT
CTTCCTCGAGAG
CTGTTCCCATGGGAATAA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
L20000

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_21_Locus:
19q13.3

# Metabolic_Enzyme_21_SNPs:
rs11569681; rs11569679; rs11569685; rs11083907; rs296365; rs11083903; rs296366; rs296367; rs2547238; rs2547241; rs212099; rs4149448; rs2910394; rs2547236; rs11083905; rs11671690; rs2547240; rs11083904; rs2637116; rs296364; rs2431829; rs296361; rs2431828; rs2431830; rs2547237; rs2910393; rs11083906; rs4149452; rs10425629; rs10426201; rs296362; rs10401763; rs296359; rs296363; rs2547235; rs7247968; rs9676884; rs212100; rs8113396; rs2547242; rs2451834; rs2547231; rs12461808; rs10425975; rs2547239; rs8108674; rs16972519; rs10420308; rs4149449; rs10425154; rs7256697; rs182420; rs296368; rs188440; rs2932766; rs10401229; rs7508610; rs10402030; rs17464626; rs177037; rs17851828; rs1131405; rs1131404; rs4149454; rs10416994; rs36012387; rs10676904; rs10048437; rs34884527; rs10697302; rs35135607; rs11668504; rs10425963; rs35486252; rs36196588; rs35795715; rs12461162; rs7251378; rs12985420; rs35150217; rs4149451; rs34559609; rs34468125; rs34642376; rs34027366; rs34692560; rs9304669; rs4149450; rs2637115; rs2547234; rs11352410; rs34339793; rs12151061; rs12975483; rs3936308; rs35243293; rs296360; rs2547233; rs2972624; rs35067360; rs28830294; rs2972622; rs35543847; rs35489406; rs4002939; rs35975330; rs177036; rs2910392; rs2972623; rs28505302; rs28762460; rs8104798; rs11569677; rs11569678; rs11569680; rs11569683; rs11569684; rs12461421; rs2547229; rs2910397; rs2910400; rs296381; rs296390; rs296391; rs296394; rs2972612; rs6509347; rs6509348; rs8105359

# Metabolic_Enzyme_21_General_References:
7678732; 1588921; 7589785; 7598806; 7710689; 1520333

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
5720

# Metabolic_Enzyme_22_Name:
UDP-glucuronosyltransferase 2B10 precursor

# Metabolic_Enzyme_22_Synonyms:
UDPGT

# Metabolic_Enzyme_22_Gene_Name:
UGT2B10

# Metabolic_Enzyme_22_Protein_Sequence:
>UDPglucuronosyltransferase 2B10 precursor
MALKWTTVLLIQLSFYFSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSAS
ILFDPNDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEILWAIND
IIRNFCKDVVSNKKLMKKLQESRFDIVFADAYLPCGELLAELFNIPFVYSHSFSPGYSFE
RHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWFQIFNMKKWDQFYSEVLG
RPTTLSETMRKADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGE
NGVVVFSLGSMVSNMTEERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQND
LLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMS
STDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAH
NLTWFQYHSLDVIGFLLACVATVLFIITKCCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_22_Number_of_Residues:
528

# Metabolic_Enzyme_22_Molecular_Weight:
60775

# Metabolic_Enzyme_22_Theoretical_pI:
9.40

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_22_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_22_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_22_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_22_Signals:
1-23

# Metabolic_Enzyme_22_Transmembrane_Regions:
492-512

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_22_GenBank_ID_Protein:
516150

# Metabolic_Enzyme_22_SwissProt_ID:
UDB10_HUMAN (P36537)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
UGT2B10

# Metabolic_Enzyme_22_Geneatlas_id:
UGT2B10

# Metabolic_Enzyme_22_hgnc_id:
HGNC:12544

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Microsome

# Metabolic_Enzyme_22_Gene_Sequence:
>1587 bp
ATGGCTCTGAAATGGACTACAGTTCTGCTGATACAACTCAGTTTTTACTTTAGCTCTGGG
AGTTGTGGAAAGGTGCTGGTATGGGCCGCAGAATACAGCCTTTGGATGAATATGAAGACA
ATCCTGAAAGAACTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCTTCC
ATTCTTTTTGATCCCAACGACTCATCCACTCTTAAACTTGAAGTTTATCCTACATCTTTA
ACTAAAACTGAATTTGAGAATATCATCATGCAATTGGTTAAGAGATTGTCAGAAATTCAA
AAAGATACATTTTGGTTACCTTTTTCACAAGAACAAGAAATCCTGTGGGCAATTAATGAC
ATAATTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAACTTATGAAAAAACTACAA
GAGTCAAGATTTGACATCGTTTTTGCAGATGCTTATTTACCCTGTGGTGAGCTGCTGGCT
GAGCTATTTAACATACCCTTTGTGTACAGTCACAGCTTCAGTCCTGGCTACTCATTTGAA
AGGCACAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAAAATTA
AGTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGCTCTATGTGCTTTATTTTGAC
TTTTGGTTCCAAATATTTAATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTAGGA
AGACCCACTACATTATCTGAGACAATGAGGAAAGCTGACATATGGCTTATGCGAAACTCC
TGGAATTTTAAATTTCCTCATCCATTCTTACCAAATGTTGATTTTGTTGGAGGACTCCAC
TGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAGTTTGTACAGAGCTCTGGAGAA
AATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGGGCC
AACGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTTTGGAGATTTGATGGG
AATAAACCAGATGCCTTAGGTCTCAATACTCGACTGTACAAGTGGATACCCCAGAATGAC
CTTCTAGGTCATCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATCTAT
GAGGCAATCTACCATGGGATCCCTATGGTGGGCATTCCATTGTTTTTTGATCAACCTGAT
AATATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGAGTGGACTTCAACACAATGTCG
AGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTCATATAAAGAGAAT
ATTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCAGTC
TTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCCAAACATCTTCGAGTTGCAGCCCAC
AACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGCTTGTGTG
GCAACCGTGCTATTTATCATCACAAAGTGTTGTCTGTTTTGTTTCTGGAAGTTTGCTAGA
AAAGGAAAGAAGGGAAAAAGGGATTAG

# Metabolic_Enzyme_22_GenBank_ID_Gene:
X63359

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_22_Locus:
4q13.2

# Metabolic_Enzyme_22_SNPs:
rs3208727; rs17146903; rs17146904; rs835313; rs835316; rs835309; rs861340; rs844342; rs1841042; rs294778; rs835311; rs2670431; rs294777; rs835317; rs7676529; rs835310; rs11726322; rs11249509; rs1968764; rs7676146; rs1849533; rs17146894; rs835314; rs294772; rs9917967; rs2054221; rs3792628; rs1849534; rs1913316; rs7657958; rs1913315; rs2926036; rs835312; rs1913317; rs4694343; rs835319; rs7673996; rs2670430; rs835315; rs4694344; rs1913318; rs7670334; rs1913320; rs11940320; rs294776; rs4694358; rs294775; rs1976666; rs4095564; rs9917968; rs2942857; rs4116824; rs3215212; rs28563143; rs1902931; rs13111730; rs12506094; rs1979281; rs11347207; rs34334121; rs12511664; rs5859144; rs5859145; rs13141448; rs4116823; rs28377589; rs35887929; rs36003814; rs34999460; rs7678703; rs9917930; rs35390620; rs1902932; rs7674011; rs6839369; rs10007687; rs4095563; rs5859146; rs1902930; rs13148664; rs33938096; rs13110924; rs5859147; rs7685333; rs28586884; rs10428371; rs294771; rs13132114; rs6839806; rs34291505; rs13131461; rs13132118; rs13114078; rs4116825; rs13111722; rs835318; rs17146905; rs34183546; rs35690388; rs11725502; rs35525464; rs11729424; rs11737566; rs11737644; rs1379809; rs1458232; rs1458233; rs294765; rs294770; rs4450999; rs4694340; rs6816491; rs6836993; rs6843220

# Metabolic_Enzyme_22_General_References:
8333863

# Metabolic_Enzyme_22_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
5818

# Macromolecular_Interacting_Partner_1_Name:
Dehydrogenase/reductase SDR family member 8 precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17-beta- HSD XI; 17betaHSDXI; 17bHSD11; 17betaHSD11; Retinal short-chain dehydrogenase/reductase 2; retSDR2; Cutaneous T-cell lymphoma- associated antigen HD-CL-03; CTCL tumor antigen HD-CL-03

# Macromolecular_Interacting_Partner_1_Gene_Name:
DHRS8

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Dehydrogenase/reductase SDR family member 8 precursor
MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLK
SKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNN
AGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVP
FLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPE
EVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKRKISVKFDAVIGYKMKAQ


# Macromolecular_Interacting_Partner_1_Number_of_Residues:
300

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
32964

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
9.70

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Lipid transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Can convert androstan-3-alpha,17-beta-diol (3alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00106:adh_short

# Macromolecular_Interacting_Partner_1_Signals:
1-19

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
6318544

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
DHRS8_HUMAN (Q8NBQ5)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
DHRS8

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
DHRS8

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:22960

# Macromolecular_Interacting_Partner_1_PDB_ID:
1YB1

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein (Potential)

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>903 bp
ATGAAATTTCTTCTGGACATCCTCCTGCTTCTCCCGTTACTGATCGTCTGCTCCCTAGAG
TCCTTCGTGAAGCTTTTTATTCCTAAGAGGAGAAAATCAGTCACCGGCGAAATCGTGCTG
ATTACAGGAGCTGGGCATGGAATTGGGAGACTGACTGCCTATGAATTTGCTAAACTTAAA
AGCAAGCTGGTTCTCTGGGATATAAATAAGCATGGACTGGAGGAAACAGCTGCCAAATGC
AAGGGACTGGGTGCCAAGGTTCATACCTTTGTGGTAGACTGCAGCAACCGAGAAGATATT
TACAGCTCTGCAAAGAAGGTGAAGGCAGAAATTGGAGATGTTAGTATTTTAGTAAATAAT
GCTGGTGTAGTCTATACATCAGATTTGTTTGCTACACAAGATCCTCAGATTGAAAAGACT
TTTGAAGTTAATGTACTTGCACATTTCTGGACTACAAAGGCATTTCTTCCTGCAATGACG
AAGAATAACCATGGCCATATTGTCACTGTGGCTTCGGCAGCTGGACATGTCTCGGTCCCC
TTCTTACTGGCTTACTGTTCAAGCAAGTTTGCTGCTGTTGGATTTCATAAAACTTTGACA
GATGAACTGGCTGCCTTACAAATAACTGGAGTCAAAACAACATGTCTGTGTCCTAATTTC
GTAAACACTGGCTTCATCAAAAATCCAAGTACAAGTTTGGGACCCACTCTGGAACCCGAG
GAAGTGGTAAACAGGCTGATGCATGGGATTCTGACTGAGCAGAAGATGATTTTTATTCCA
TCTTCTATAGCTTTTTTAACAACATTGGAAAGGATCCTTCCTGAGCGTTTCCTGGCAGTT
TTAAAACGAAAAATCAGTGTTAAGTTTGATGCAGTTATTGGATATAAAATGAAAGCGCAA
TAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AF126780

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_1_Locus:
4q22.1

# Macromolecular_Interacting_Partner_1_SNPs:
rs9991501; rs6531985; rs34025653; rs4438729; rs6853049; rs11732896; rs7691791; rs6840247; rs6531984; rs7667870; rs6845304; rs7682516; rs4585263; rs6849846; rs7688962; rs7665549; rs10028441; rs10213098; rs11946278; rs6849382; rs7679024; rs7662528; rs6531980; rs6531983; rs6531978; rs7690170; rs6857133; rs4574370; rs4635784; rs10022096; rs6811010; rs7677036; rs11721653; rs9307030; rs9991773; rs7682892; rs6818142; rs12649023; rs9307029; rs6531979; rs7665638; rs11946391; rs10050247; rs7685308; rs11734330; rs6833678; rs6531981; rs4469031; rs7664717; rs7698689; rs6817242; rs12642212; rs7671900; rs11097147; rs11737402; rs9684766; rs9307033; rs11097138; rs11939415; rs9996312; rs11727469; rs9283038; rs11097142; rs7665178; rs11931674; rs10002620; rs10433938; rs13150578; rs10049870; rs12108413; rs10856866; rs11930147; rs7697960; rs11946007; rs7684816; rs13435093; rs13102469; rs7690005; rs10856868; rs7661455; rs11930112; rs9993968; rs10856865; rs10049871; rs12510079; rs12386427; rs11097148; rs34853672; rs12643799; rs7696417; rs12505484; rs10856864; rs4443241; rs9715078; rs9307031; rs7667924; rs10433939; rs11930079; rs11097132; rs9715814; rs12505515; rs7677323; rs7689292; rs11097131; rs10025212; rs10004027; rs10222732; rs9684778; rs10049877; rs7676865; rs9968375; rs11946465; rs10856867; rs11934060; rs11930151; rs7665207; rs10433942; rs11939903; rs12644152; rs11939901; rs10032597; rs13138636; rs13138404; rs11549855; rs11549856; rs17850359; rs17850360; rs1127976; rs28654511; rs35289628; rs7681452; rs9968374; rs34915404; rs35304276; rs7677089; rs11505071; rs11097141; rs35707697; rs28566586; rs28379583; rs7660178; rs12054554; rs10433940; rs34923084; rs7698196; rs10049876; rs28427373; rs11314228; rs35567335; rs9761964; rs11097145; rs10695001; rs9968378; rs7696693; rs10012256; rs11390748; rs11379289; rs11505072; rs34215760; rs28889052; rs34864984; rs34512161; rs4435709; rs12499635; rs34571928; rs11097146; rs34601270; rs10029525; rs28709117; rs33949743; rs7675202; rs10618602; rs11418537; rs13126720; rs35829908; rs7671001; rs11097140; rs35724745; rs34571158; rs11398850; rs11097139; rs28433555; rs9684665; rs13146673; rs13133008; rs4257627; rs35359937; rs35581746; rs10433944; rs5860065; rs11097134; rs11495896; rs34360552; rs10627889; rs34847051; rs36085525; rs10856863; rs34733992; rs10003964; rs4422389; rs34828348; rs34740220; rs34311718; rs28514476; rs35122175; rs9968472; rs9799596; rs11458362; rs13124657; rs36047590; rs9684661; rs9685939; rs6839620; rs28696943; rs11722370; rs35787384; rs35905628; rs12386465; rs5860066; rs13138956; rs35699282; rs9761953; rs12386426; rs11097135; rs34342374; rs34976142; rs12505512; rs11304481; rs34331407; rs13105267; rs11097144; rs12649727; rs35056297; rs6839488; rs11409719; rs34513313; rs7675190; rs9799600; rs11443991; rs10592172; rs35077787; rs35602834; rs7436357; rs28706177; rs11369073; rs9684675; rs35017020; rs13105100; rs7677270; rs10433943; rs9307034; rs10028111; rs10546404; rs9761931; rs7678904; rs11097136; rs10034537; rs9715072; rs12054555; rs9684659; rs10684477; rs34984566; rs10000196; rs7697871; rs34827349; rs13132871; rs36084090; rs28415220; rs9307032; rs10433941; rs28610908; rs11375790; rs35482923; rs9684649; rs28655026; rs35761085; rs9715490; rs11097143; rs4331743; rs34224827; rs7661662; rs10706118; rs12512628; rs7694996; rs9884512; rs9760980; rs9760969; rs11097133; rs12054553; rs28445336; rs11097137; rs5860067; rs34851429; rs35478513; rs13119092; rs7697166; rs11305478; rs7671151; rs34137527; rs6840102; rs34109910; rs11514606; rs6817185; rs13126721; rs34525853; rs35898510; rs34694146; rs34505217; rs28366407; rs35236094; rs35123085; rs35767759; rs34521557; rs34714042; rs34538986; rs10010988; rs10023606; rs12500021; rs4388049; rs6840298; rs7674658; rs7699172

# Macromolecular_Interacting_Partner_1_General_References:
10800688; 12975309; 9888557; 11165019; 12697717

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
7549

# Macromolecular_Interacting_Partner_2_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
INS

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_2_Signals:
1-24

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
INS

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_2_Locus:
11p15.5

# Macromolecular_Interacting_Partner_2_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_2_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_2_References:
1874169; 9861330

End of HMDB00031

Beginning of HMDB00032
# Accession_No:
HMDB00032

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-09-26 12:54:18

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
7-Dehydrocholesterol

# Description:
7-Dehydrocholesterol is a zoosterol (a sterol produced by animals rather than plants).  It is a provitamin-D. The presence of this compound in skin enables humans to manufacture vitamin D3 from ultra-violet rays in the sun light, via an intermediate isomer provitamin D3. It is also found in breast milk.

# Synonyms:
(-)-7-dehydrocholesterol; (3b)-Cholesta-5,7-dien-3-ol; (3beta)-Cholesta-5,7-dien-3-ol; 10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol; 17-(1,5-dimethylhexyl)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; 5,7-Cholestadien-3-beta-ol; 5,7-Cholestandien-3-ol; 5,7-Cholestandien-3beta-ol; 7,8-Didehydrocholesterol; 7,8-dehydro-cholesterol; 7-Dehydrocholesterin; 7-Dehydrocholesterol; 7-dehydro-cholesterol; 7DHC; Cholesta-5,7-dien-3-beta-ol; Cholesta-5,7-dien-3-ol; Cholesta-5,7-dien-3beta-ol; Dehydrocholesterin; Dehydrocholesterol; Provitamin D3; cholesta-5,7-dien-3 beta -ol; cholesta-5,7-dien-3b-ol; delta5,7-Cholestadien-3beta-ol; delta5,7-Cholesterol; delta7-Cholesterol; provitamin-D3

# Chemical_IUPAC_Name:
10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol

# Chemical_Formula:
C27H44O

# Chemical_Structure:
tbl_chemical:::HMDB00032_ZOOM.png:::119283142813985097

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00032_THUMB.png:::119283142580378387

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Sterols

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
secondary alcohol; alkene

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
384.33920

# Molecular_Weight_Avg:
384.63766

# Smiles_String_isomeric:
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

# Smiles_String_canonical:
CC(C)CCCC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C

# KEGG_Compound_ID:
C01164

# BioCyc_ID:
7-DEHYDRO-CHOLESTEROL

# PubChem_CID:
439423

# PubChem_SID:
3132652; 8144019; 4391; 12157001; 7850692; 10298334

# OMIM_ID:
223370; 270400

# Metagene_ID:
SMITH-LEMLI-OPITZ SYNDROME: 337

# BiGG_ID:
36958

# Wikipedia_ID:
7-Dehydrocholesterol

# METLIN_ID:
5101

# Ref_ID:
11710930; 12887150; 9290088; 10946022; 11590227; 9266395; 10069708; 11141372; 16451140; 2277111

# ChEBI_ID:
17759

# CAS_Registry_Number:
434-16-2

# InChI:
InChI=1/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1

# Synthesis_Reference:
Journal of the American Chemical Society  (1951),  73  4496.

# Melting_Point:
150.5 oC

# Melting_Point_predicted:
124.9 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
1.08e-07 mg/mL [MEYLAN,WM et al. (1996)]; 1.48e-04 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
7.30 [Predicted by ALOGPS]; 7.2 [Predicted by PubChem via XLOGP]; 8.65 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::7-Dehydrocholesterol.pdf:::113256219138653277

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::7-Dehydrocholesterol.mol:::1132723802437137144

# SDF_File_[Text]:
tbl_chemical:::HMDB00032.sdf:::119283141907277821

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00032.pdb:::119283142406874161

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:


# H_NMR_FIDS_Spectra_Sykes:


# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050106_P00_07_IS_2DHSQC_80.png:::114828332386044165

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050106_P00_07_IS_2DHSQC_80.zip:::1148283323884359

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050106_P00_07_IS_2DHSQC_80_Assigned.png:::116198757027244469

# Predicted_H_NMR_Spectrum:
tbl_chemical:::7-Dehydrocholesterol.gif:::1132732100562804871

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00032_peaks.txt:::1156309498659645949

# Predicted_C_NMR_Spectrum:
tbl_chemical:::7-Dehydrocholesterol_C.gif:::1132737661823934196

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00032_peaks.txt:::1156310690459304260

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00032L.png:::117555261855225736; Medium Energy:tbl_ms:::HMDB00032M.png:::117555266965166177; High Energy:tbl_ms:::HMDB00032H.png:::117555270849492203

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane; Cytoplasm; endoplasmic reticulum

# Tissue_Location:
Adrenal Gland; Brain; Epidermis; Fetus; Fibroblasts; Liver; Skin; Testis

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	0.029 (0.0068-0.051)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	16451140
Blood	0.005 +/- 0.0022	uM	Adult:>18_yrs_old	Both	Normal	11590227
Cerebrospinal_Fluid(CSF)	0 - 0.02	umol/L	Adult:>18_yrs_old	Both	Normal	10946022


# Concentration_[Abnormal]:
Cerebrospinal_Fluid(CSF)	0.3 +/- 0.2 (0.1 - 0.6)	umol/L	Infant:0-1_yr_old	Both	Smith-Lemli-Opitz syndrome	9266395


# Associated_Disorders:
RSH Syndrome; Smith-Lemli-Opitz syndrome

# Pathway_Names:
Biosynthesis of steroids

# Pathway_Images:
Not Available

# KEGG_Images:
map00100

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5819

# Metabolic_Enzyme_1_Name:
7-dehydrocholesterol reductase

# Metabolic_Enzyme_1_Synonyms:
7-DHC reductase; Sterol Delta(7-reductase; Putative sterol reductase SR-2

# Metabolic_Enzyme_1_Gene_Name:
DHCR7

# Metabolic_Enzyme_1_Protein_Sequence:
>7dehydrocholesterol reductase
MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL
FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL
ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF

# Metabolic_Enzyme_1_Number_of_Residues:
475

# Metabolic_Enzyme_1_Molecular_Weight:
54490

# Metabolic_Enzyme_1_Theoretical_pI:
8.82

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC)

# Metabolic_Enzyme_1_Pathway:
map00100  Biosynthesis of steroids

# Metabolic_Enzyme_1_Reaction:
cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01222:ERG4_ERG24

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
40-60
154-174
177-197
266-286
306-326
331-351
420-440

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.3.1.21

# Metabolic_Enzyme_1_GenBank_ID_Protein:
4191398

# Metabolic_Enzyme_1_SwissProt_ID:
DHCR7_HUMAN (Q9UBM7)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
DHCR7

# Metabolic_Enzyme_1_Geneatlas_id:
DHCR7

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2860

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein

# Metabolic_Enzyme_1_Gene_Sequence:
>1428 bp
ATGGCTGCAAAATCGCAACCCAACATTCCCAAAGCCAAGAGTCTAGATGGCGTCACCAAT
GACAGAACCGCATCTCAAGGGCAGTGGGGCCGTGCCTGGGAGGTGGACTGGTTTTCACTG
GCGAGCGTCATCTTCCTACTGCTGTTCGCCCCCTTCATCGTCTACTACTTCATCATGGCT
TGTGACCAATACAGCTGCGCCCTGACCGGCCCTGTGGTGGACATCGTCACCGGACATGCT
CGGCTCTCGGACATCTGGGCCAAGACTCCACCTATAACGAGGAAAGCCGCCCAGCTCTAT
ACCTTGTGGGTCACCTTCCAGGTGCTTCTGTACACGTCTCTCCCTGACTTCTGCCATAAG
TTTCTACCCGGCTACGTAGGAGGCATCCAGGAGGGGGCCGTGACTCCTGCAGGGGTTGTG
AACAAGTATCAGATCAACGGCCTGCAAGCCTGGCTCCTCACGCACCTGCTCTGGTTTGCA
AACGCTCATCTCCTGTCCTGGTTCTCGCCCACCATCATCTTCGACAACTGGATCCCACTG
CTGTGGTGCGCCAACATCCTTGGCTATGCCGTCTCCACCTTCGCCATGGTCAAGGGCTAC
TTCTTCCCCACCAGCGCCAGAGACTGCAAATTCACAGGCAATTTCTTTTACAACTACATG
ATGGGCATCGAGTTTAACCCTCGGATCGGGAAGTGGTTTGACTTCAAGCTGTTCTTCAAT
GGGCGCCCCGGGATCGTCGCCTGGACCCTCATCAACCTGTCCTTCGCAGCGAAGCAGCGG
GAGCTCCACAGCCATGTGACCAATGCCATGGTCCTGGTCAACGTCCTGCAGGCCATCTAC
GTGATTGACTTCTTCTGGAACGAAACCTGGTACCTGAAGACCATTGACATCTGCCATGAC
CACTTCGGGTGGTACCTGGGCTGGGGCGACTGTGTCTGGCTGCCTTATCTTTACACGCTG
CAGGGTCTGTACTTGGTGTACCACCCCGTGCAGCTGTCCACCCCGCACGCCGTGGGCGTC
CTGCTGCTGGGCCTGGTGGGCTACTACATCTTCCGGGTGGCCAACCACCAGAAGGACCTG
TTCCGCCGCACGGATGGGCGCTGCCTCATCTGGGGCAGGAAGCCCAAGGTCATCGAGTGC
TCCTACACATCCGCCGACGGGCAGAGGCACCACAGCAAGCTGCTGGTGTCGGGCTTCTGG
GGCGTGGCCCGCCACTTCAACTACGTCGGCGACCTGATGGGCAGCCTGGCCTACTGCCTG
GCCTGTGGCGGTGGCCACCTGCTGCCCTACTTCTACATCATCTACATGGCCATCCTGCTG
ACCCACCGCTGCCTCCGGGACGAGCACCGCTGCGCCAGCAAGTACGGCCGGGACTGGGAG
CGCTACACCGCCGCAGTGCCTTACCGCCTGCTGCCTGGAATCTTCTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF096305

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_1_Locus:
11q13.2-q13.5

# Metabolic_Enzyme_1_SNPs:
rs760242; rs12577137; rs1790334; rs1044482; rs949177; rs760241; rs4316537; rs909217; rs1790345; rs1044535; rs3750997; rs12573951; rs10450661; rs7690; rs1790324; rs736894; rs1790328; rs1790330; rs1792268; rs17161531; rs1790327; rs1790329; rs1630498; rs949176; rs1792264; rs2852853; rs11603330; rs2851693; rs11606033; rs1790325; rs1792265; rs1790326; rs10898144; rs12422045; rs1792270; rs1790348; rs7122671; rs1790346; rs4944949; rs28364617; rs7928249; rs10450662; rs1790347; rs4944946; rs11555217; rs1127869; rs28939698; rs12800; rs35946774; rs11233662; rs34258235; rs5792560; rs1802126; rs34995793; rs12407; rs7950991; rs11233706; rs34541828; rs34240558; rs1802125; rs11555218; rs35616583; rs12271811; rs1802378; rs34463022; rs35826756; rs2852855; rs28364772; rs12281087; rs34405099; rs2851692; rs12294879; rs2852857; rs2852850; rs12283656; rs12285189; rs760238; rs2852849; rs2852858; rs760240; rs1790331; rs1792223; rs1792267; rs2852851; rs2852854; rs5792559; rs34177783; rs11233679; rs2852856; rs760239; rs1790332; rs2851691; rs28364773; rs2852852; rs35589965; rs11233713; rs35649052; rs28364616; rs11546508; rs34809983; rs7944310; rs12804192; rs11366361; rs12270619; rs12272475; rs12280295; rs12285168; rs12285333; rs12419279; rs12419334; rs12785878; rs12797951; rs1623080; rs1629055; rs1790349; rs1790351; rs1790352; rs1790353; rs1790373; rs1792271; rs1792272; rs1792273; rs1792275; rs1792276; rs1792277; rs1792278; rs1792279; rs1792316; rs2002063; rs2002064; rs3184354; rs4944955; rs4944956; rs4944957; rs4944958; rs4944959; rs7944926

# Metabolic_Enzyme_1_General_References:
9683613; 9465114; 9878250; 9634533; 9653161; 10677299; 10995508; 11175299; 12949967

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5367

# Metabolic_Enzyme_2_Name:
Lathosterol oxidase

# Metabolic_Enzyme_2_Synonyms:
Lathosterol 5-desaturase; Delta(7-sterol 5-desaturase; C-5 sterol desaturase; Sterol-C5- desaturase

# Metabolic_Enzyme_2_Gene_Name:
SC5DL

# Metabolic_Enzyme_2_Protein_Sequence:
>Lathosterol oxidase
MDLVLRVADYYFFTPYVYPATWPEDDIFRQAISLLIVTNVGAYILYFFCATLSYYFVFDH
ALMKHPQFLKNQVRREIKFTVQALPWISILTVALFLLEIRGYSKLHDDLGEFPYGLFELV
VSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIPTPFASHAFHPIDGFLQSLPY
HIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQILQPFINGSAHHTDHHMFFDYNY
GQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTKTE

# Metabolic_Enzyme_2_Number_of_Residues:
299

# Metabolic_Enzyme_2_Molecular_Weight:
35301

# Metabolic_Enzyme_2_Theoretical_pI:
8.24

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol

# Metabolic_Enzyme_2_Pathway:
Not Available

# Metabolic_Enzyme_2_Reaction:
Not Available

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01598:Sterol_desat

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
32-52
79-99
117-137
186-206

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.14.21.6

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1906796

# Metabolic_Enzyme_2_SwissProt_ID:
SC5D_HUMAN (O75845)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
SC5DL

# Metabolic_Enzyme_2_Geneatlas_id:
SC5DL

# Metabolic_Enzyme_2_hgnc_id:
HGNC:10547

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein (Probable)

# Metabolic_Enzyme_2_Gene_Sequence:
>711 bp
ATGGATCTTGTACTCCGTGTTGCAGATTACTATTTTTTTACACCATACGTGTATCCAGCC
ACATGGCCAGAAGATGACATCTTCCGACAAGCTATTAGTCTTCTGATTGTAACAAATGTT
GGTGCTTACATCCTTTATTTCTTCTGTGCAACACTGAGCTATTATTTTGTCTTCGATCAT
GCATTAATGAAACATCCACAATTTTTAAAGAATCAAGTCCGTCGAGAGATTAAGTTTACT
GTCCAGGCATTGCCATGGATAAGTATTCTTACTGTTGCACTGTTCTTGCTGGAGATAAGA
GGTTACAGCAAATTACATGATGACCTAGGAGAGTTTCCATATGGATTGTTTGAACTTGTC
GTTAGTATAATATCTTTCCTCTTTTTCACTGACATGTTCATCTACTGGATTCACAGAGGC
CTTCATCATAGACTGGTATATAAGCGCCTACATAAACCTCACCATATTTGGAAGATTCCT
ACTCCATTTGCAAGTCATGCTTTTCACCCTATTGATGGCTTTCTTCAGAGTCTACCTTAC
CATATATACCCTTTTATCTTTCCATTACACAAGGTGGTTTATTTAAGTCTGTACATCTTG
GTTAATATCTGGACAATTTCCATTCATGACGGTGATTTTCGTGTAAGAATGAAAAATTAT
TCAATGGAGAGTTTACAAAGACTGAATAGATTATTGCCCAGTTATTCTTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
D85181

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_2_Locus:
11q23.3

# Metabolic_Enzyme_2_SNPs:
rs1061332; rs11218245; rs17125142; rs7112214; rs11823304; rs12362657; rs7930204; rs2060008; rs7942396; rs2060007; rs12786590; rs35536707; rs11551925; rs17854634; rs1801852; rs34614904; rs35233317; rs11551924; rs34831010; rs35940360; rs35781210; rs35783080; rs11218244; rs10712296; rs35440276; rs7943648; rs35224843; rs11415316; rs12418379; rs12421209; rs10750184; rs10892720; rs10892721; rs11218247; rs11218248; rs12223482; rs12223498; rs12275106; rs12284608; rs12287112; rs12292444; rs12421079; rs12421277; rs1560409; rs2115923; rs2115925; rs2163281; rs3741013; rs6589870; rs6589872; rs6589873; rs7103341; rs7115581; rs7115602; rs7125671; rs7128047; rs7128664; rs727422; rs751417; rs7924558; rs7924930; rs7928868; rs7929848; rs7939864; rs891435; rs891441

# Metabolic_Enzyme_2_General_References:
8976377; 10344195; 10786622; 12189593; 12812989

# Metabolic_Enzyme_2_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
6198

# Macromolecular_Interacting_Partner_1_Name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase

# Macromolecular_Interacting_Partner_1_Synonyms:
HMG-CoA reductase

# Macromolecular_Interacting_Partner_1_Gene_Name:
HMGCR

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>3hydroxy3methylglutarylcoenzyme A reductase
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT
QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS
SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV
AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRAC
DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI
SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV
LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR
IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
888

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
97477

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.72

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  hydroxymethylglutaryl-CoA reductase (NADPH) activity
Function:  hydroxymethylglutaryl-CoA reductase (NADPH) activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  hydroxymethylglutaryl-CoA reductase (NADPH) activity
 ||
>>>
Process:  primary metabolism
Process:  lipid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  organelle membrane
Component:  endoplasmic reticulum membrane
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Lipid transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis

# Macromolecular_Interacting_Partner_1_Pathway:
map00100  Biosynthesis of steroids

# Macromolecular_Interacting_Partner_1_Reaction:
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00368:HMG-CoA_red

# Macromolecular_Interacting_Partner_1_Signals:
1-23

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 1.1.1.34

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
306865

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
HMDH_HUMAN (P04035)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
HMGCR

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
HMGCR

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:5006

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein. Peroxisome; peroxisomal membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>2667 bp
ATGTTGTCAAGACTTTTTCGAATGCATGGCCTCTTTGTGGCCTCCCATCCCTGGGAAGTC
ATAGTGGGGACAGTGACACTGACCATCTGCATGATGTCCATGAACATGTTTACTGGTAAC
AATAAGATCTGTGGTTGGAATTATGAATGTCCAAAGTTTGAAGAGGATGTTTTGAGCAGT
GACATTATAATTCTGACAATAACACGATGCATAGCCATCCTGTATATTTACTTCCAGTTC
CAGAATTTACGTCAACTTGGATCAAAATATATTTTGGGTATTGCTGGCCTTTTCACAATT
TTCTCAAGTTTTGTATTCAGTACAGTTGTCATTCACTTCTTAGACAAAGAATTGACAGGC
TTGAATGAAGCTTTGCCCTTTTTCCTACTTTTGATTGACCTTTCCAGAGCAAGCACATTA
GCAAAGTTTGCCCTCAGTTCCAACTCACAGGATGAAGTAAGGGAAAATATTGCTCGTGGA
ATGGCAATTTTAGGTCCTACGTTTACCCTCGATGCTCTTGTTGAATGTCTTGTGATTGGA
GTTGGTACCATGTCAGGGGTACGTCAGCTTGAAATTATGTGCTGCTTTGGCTGCATGTCA
GTTCTTGCCAACTACTTCGTGTTCATGACTTTCTTCCCAGCTTGTGTGTCCTTGGTATTA
GAGCTTTCTCGGGAAAGCCGCGAGGGTCGTCCAATTTGGCAGCTCAGCCATTTTGCCCGA
GTTTTAGAAGAAGAAGAAAATAAGCCGAATCCTGTAACTCAGAGGGTCAAGATGATTATG
TCTCTAGGCTTGGTTCTTGTTCATGCTCACAGTCGCTGGATAGCTGATCCTTCTCCTCAA
AACAGTACAGCAGATACTTCTAAGGTTTCATTAGGACTGGATGAAAATGTGTCCAAGAGA
ATTGAACCAAGTGTTTCCCTCTGGCAGTTTTATCTCTCTAAAATGATCAGCATGGATATT
GAACAAGTTATTACCCTAAGTTTAGCTCTCCTTCTGGCTGTCAAGTACATCTTCTTTGAA
CAAACAGAGACAGAATCTACACTCTCATTAAAAAACCCTATCACATCTCCTGTAGTGACA
CAAAAGAAAGTCCCAGACAATTGTTGTAGACGTGAACCTATGCTGGTCAGAAATAACCAG
AAATGTGATTCAGTAGAGGAAGAGACAGGGATAAACCGAGAAAGAAAAGTTGAGGTTATA
AAACCCTTAGTGGCTGAAACAGATACCCCAAACAGAGCTACATTTGTGGTTGGTAACTCC
TCCTTACTCGATACTTCATCAGTACTGGTGACACAGGAACCTGAAATTGAACTTCCCAGG
GAACCTCGGCCTAATGAAGAATGTCTACAGATACTTGGGAATGCAGAGAAAGGTGCAAAA
TTCCTTAGTGATGCTGAGATCATCCAGTTAGTCAATGCTAAGCATATCCCAGCCTACAAG
TTGGAAACTCTGATGGAAACTCATGAGCGTGGTGTATCTATTCGCCGACAGTTACTTTCC
AAGAAGCTTTCAGAACCTTCTTCTCTCCAGTACCTACCTTACAGGGATTATAATTACTCC
TTGGTGATGGGAGCTTGTTGTGAGAATGTTATTGGATATATGCCCATCCCTGTTGGAGTG
GCAGGACCCCTTTGCTTAGATGAAAAAGAATTTCAGGTTCCAATGGCAACAACAGAAGGT
TGTCTTGTGGCCAGCACCAATAGAGGCTGCAGAGCAATAGGTCTTGGTGGAGGTGCCAGC
AGCCGAGTCCTTGCAGATGGGATGACTCGTGGCCCAGTTGTGCGTCTTCCACGTGCTTGT
GACTCTGCAGAAGTGAAAGCCTGGCTCGAAACATCTGAAGGGTTCGCAGTGATAAAGGAG
GCATTTGACAGCACTAGCAGATTTGCACGTCTACAGAAACTTCATACAAGTATAGCTGGA
CGCAACCTTTATATCCGTTTCCAGTCCAGGTCAGGGGATGCCATGGGGATGAACATGATT
TCAAAGGGTACAGAGAAAGCACTTTCAAAACTTCACGAGTATTTCCCTGAAATGCAGATT
CTAGCCGTTAGTGGTAACTATTGTACTGACAAGAAACCTGCTGCTATAAATTGGATAGAG
GGAAGAGGAAAATCTGTTGTTTGTGAAGCTGTCATTCCAGCCAAGGTTGTCAGAGAAGTA
TTAAAGACTACCACAGAGGCTATGATTGAGGTCAACATTAACAAGAATTTAGTGGGCTCT
GCCATGGCTGGGAGCATAGGAGGCTACAACGCCCATGCAGCAAACATTGTCACCGCCATC
TACATTGCCTGTGGACAGGATGCAGCACAGAATGTTGGTAGTTCAAACTGTATTACTTTA
ATGGAAGCAAGTGGTCCCACAAATGAAGATTTATATATCAGCTGCACCATGCCATCTATA
GAGATAGGAACGGTGGGTGGTGGGACCAACCTACTACCTCAGCAAGCCTGTTTGCAGATG
CTAGGTGTTCAAGGAGCATGCAAAGATAATCCTGGGGAAAATGCCCGGCAGCTTGCCCGA
ATTGTGTGTGGGACCGTAATGGCTGGGGAATTGTCACTTATGGCAGCATTGGCAGCAGGA
CATCTTGTCAAAAGTCACATGATTCACAACAGGTCGAAGATCAATTTACAAGACCTCCAA
GGAGCTTGCACCAAGAAGACAGCCTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M11058

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_1_Locus:
5q13.3-q14

# Macromolecular_Interacting_Partner_1_SNPs:
rs5908; rs10038095; rs12916; rs10045497; rs5909; rs17883498; rs17244932; rs17238554; rs17238379; rs17244771; rs17238372; rs17244764; rs17238393; rs17244757; rs17244743; rs17244778; rs6805; rs10474435; rs2241402; rs2878419; rs3846662; rs3846661; rs10942735; rs3846663; rs6453131; rs6882842; rs17244855; rs12654264; rs7717396; rs17244841; rs17244806; rs17238596; rs17238540; rs17244862; rs10473972; rs10474434; rs17244890; rs11742194; rs10515198; rs17238477; rs17244848; rs17244883; rs17238449; rs17244834; rs2303152; rs17244813; rs17238484; rs3064877; rs11957984; rs10053643; rs17238435; rs2303151; rs17238456; rs17238603; rs35767444; rs17238575; rs17238589; rs17244897; rs17244827; rs10063134; rs35635349; rs3843482; rs17238519; rs17238498; rs17244792; rs17244799; rs17244960; rs17244785; rs17238442; rs17244876; rs4629571; rs3761739; rs17244953; rs17238337; rs17238330; rs17244708; rs3761738; rs3761740; rs17244946; rs17244715; rs34652146; rs34334938; rs35436905; rs35561739; rs36010179; rs1044453; rs11402730; rs35855355; rs34198674; rs11453557; rs12657545; rs35306582; rs10683134; rs11379632; rs17648121; rs33988510; rs11443896; rs10590407; rs2898551; rs3064191; rs35744174; rs35152895; rs35491024; rs33926107; rs13436857; rs11743717; rs11749783; rs11957619; rs16872521; rs16872523; rs3180743; rs35176659; rs3733907; rs3761741; rs3843480; rs3843481; rs3931914; rs4703670; rs4704209; rs7703051

# Macromolecular_Interacting_Partner_1_General_References:
2991281; 10698924; 10391209

# Macromolecular_Interacting_Partner_1_References:
7557099; 9548596

End of HMDB00032

Beginning of HMDB00033
# Accession_No:
HMDB00033

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-19 15:13:42

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Carnosine

# Description:
Carnosine (beta-alanyl-L-histidine) is found exclusively in animal tissues. Carnosine has the potential to suppress many of the biochemical changes (e.g., protein oxidation, glycation, AGE formation, and cross-linking) that accompany aging and associated pathologies. (PMID 16804013) Carnosine is a dipeptide of the amino acids beta-alanine and histidine. It is highly concentrated in muscle and brain tissues. Some autistics patients take it as a dietary supplement, and attribute an improvement in their condition to it. Supplemental carnosine may increase corticosterone levels. This may explain the "hyperactivity" seen in autistic subjects at higher doses.  Carnosine also exhibits some anti-oxidant effects.

# Synonyms:
Beta-Alanyl-L-histidine; Carnosine; Ignotine; Karnozin; Karnozzn; L-Carnosine; N-(3-Aminopropanoyl)histidine; N-(b-Alanyl)-L-histidine; N-b-alanyl-L-Histidine; N-beta-alanyl-L-Histidine; b-Alanyl-L-histidine; b-Alanylhistidine; beta-Alanylhistidine

# Chemical_IUPAC_Name:
2-(3-aminopropanoylamino)-3-(3H-imidazol-4-yl)propanoic acid

# Chemical_Formula:
C9H14N4O3

# Chemical_Structure:
tbl_chemical:::HMDB00033_ZOOM.png:::119283143906862773

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00033_THUMB.png:::119283143702551120

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid; secondary carboxylic acid amide; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of beta-Alanine metabolism; Component of Histidine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
226.10658

# Molecular_Weight_Avg:
226.23245

# Smiles_String_isomeric:
C[C@H](N)C(=O)C([C@H](N)C(O)=O)C1=CNC=N1

# Smiles_String_canonical:
CC(N)C(=O)C(C(N)C(O)=O)C1=CNC=N1

# KEGG_Compound_ID:
C00386

# BioCyc_ID:
CARNOSINE

# PubChem_CID:
439224

# PubChem_SID:
11366634; 3676; 11494992; 11488270; 10298255; 11537748; 11377358; 11491027; 11369196; 11361828; 11113307; 8143363; 11487230; 3138777; 11364072; 11493487; 11484264; 11375363; 11341645; 11372223

# OMIM_ID:
212200; 236130; 237400

# Metagene_ID:
GABA TRANSAMINASE DEFICIENCY: 32; CARNOSINURIA: 82

# BiGG_ID:
1800369

# Wikipedia_ID:
Carnosine

# METLIN_ID:
38

# Ref_ID:
15941308; 16181134; 9928418; 16162015; 11707898; 2674258; 15878720; 11976203; 1735411; 11470131; 12139778; 11911459; 9029640; 16287364; 15853927; 8689392

# ChEBI_ID:
15727

# CAS_Registry_Number:
305-84-0

# InChI:
InChI=1/C9H14N4O3/c1-4(10)8(14)6(7(11)9(15)16)5-2-12-3-13-5/h2-4,6-7H,10-11H2,1H3,(H,12,13)(H,15,16)/t4-,6?,7-/m0/s1

# Synthesis_Reference:
Synthesis of carnosine by trimethylsilyl protection.     Vezenkov, L.; Yanachkov, O.    Dep. Org. Chem.,  Higher Inst. Chem. Technol.,  Sofia,  Bulg.    Dokladi na Bulgarskata Akademiya na Naukite  (1991),  44(8),  53-6

# Melting_Point:
253-256 oC

# Melting_Point_predicted:
109.3 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
384 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
82.1 mg/mL [MEYLAN,WM et al. (1996)]; 32.1 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.72 [Predicted by ALOGPS]; -4.1 [Predicted by PubChem via XLOGP]; -1.81 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Carnosine.pdf:::1132562191646531638

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Carnosine.mol:::1132723802515305277

# SDF_File_[Text]:
tbl_chemical:::HMDB00033.sdf:::119283143249152549

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00033.pdb:::119283143529157339

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::050110_P00_02_IS_1DP_presat_expanded_2.gif:::114460751555437021

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::050110_P00_02_IS_1DP_presat.zip:::1175124305325404209

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050110_P00_02_IS_1DP_Assigned.png:::116414673131324051

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::050110_P00_02_IS_1DC_76.jpg:::114168392349448013

# C_NMR_FIDS_Spectra:
tbl_cnmr:::050110_P00_02_IS_1DC_76.zip:::114168392318065290

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::050110_P00_02_IS_1DC_76_Assigned.jpg:::116000060034661306

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050110_P00_02_IS_2DHSQC_254.jpg:::114608659377263489

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050110_P00_02_IS_2DHSQC_254.zip:::114608659379341224

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050110_P00_02_IS_2DHSQC_254_Assigned.jpg:::114608659406624555

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Carnosine.gif:::115324906652996401

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00033_peaks.txt:::1156309499758261496

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Carnosine_C.gif:::115324906653888774

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00033_peaks.txt:::1156310691468422149

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00033L.png:::117555261937624170; Medium Energy:tbl_ms:::HMDB00033M.png:::117555267061464108; High Energy:tbl_ms:::HMDB00033H.png:::11755527091703986

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000246.png:::116907445173427345

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000246.txt:::116907445173416905

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000246.png:::116890832812577418

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000246.txt:::11689083283432036

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Brain; Fibroblasts; Intestine; Kidney; Liver; Muscle; Neurons; Skeletal Muscle

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	<6.579	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Urine	0.014-0.032	umol/mmol_creatinine	Adult:>18_yrs_old	N/A	Normal	Doctor's Data
Urine	1.1+/-0.5	umol/mmol_creatinine	N/A	Both	Normal	9029640
Blood	3.1 +/- 7.5	umol/L	Infant:0-1_yr_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 80-97. Edited by Cornelius Lentner. ; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. ; Basle, Switzerland c1981-1992. 
Blood	81.5 (0.0-163.0)	uM	Adult:>18_yrs_old	Both	Normal	15941308


# Concentration_[Abnormal]:
Urine	56.56-113.1	umol/mmol_creatinine	Adult:>18_yrs_old	N/A	Carnosinuria	2674258


# Associated_Disorders:
Carnosinuria; Chronic Renal Failure; Neuromuscular Diseases

# Pathway_Names:
Beta-Alanine metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00410

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5713

# Metabolic_Enzyme_1_Name:
Beta-Ala-His dipeptidase precursor

# Metabolic_Enzyme_1_Synonyms:
Carnosine dipeptidase 1; CNDP dipeptidase 1; Serum carnosinase; Glutamate carboxypeptidase-like protein 2

# Metabolic_Enzyme_1_Gene_Name:
CNDP1

# Metabolic_Enzyme_1_Protein_Sequence:
>BetaAlaHis dipeptidase precursor
MDPKLGRMAASLLAVLLLLLERGMFSSPSPPPALLEKVFQYIDLHQDEFVQTLKEWVAIE
SDSVQPVPRFRQELFRMMAVAADTLQRLGARVASVDMGPQQLPDGQSLPIPPVILAELGS
DPTKGTVCFYGHLDVQPADRGDGWLTDPYVLTEVDGKLYGRGATDNKGPVLAWINAVSAF
RALEQDLPVNIKFIIEGMEEAGSVALEELVEKEKDRFFSGVDYIVISDNLWISQRKPAIT
YGTRGNSYFMVEVKCRDQDFHSGTFGGILHEPMADLVALLGSLVDSSGHILVPGIYDEVV
PLTEEEINTYKAIHLDLEEYRNSSRVEKFLFDTKEEILMHLWRYPSLSIHGIEGAFDEPG
TKTVIPGRVIGKFSIRLVPHMNVSAVEKQVTRHLEDVFSKRNSSNKMVVSMTLGLHPWIA
NIDDTQYLAAKRAIRTVFGTEPDMIRDGSTIPIAKMFQEIVHKSVVLIPLGAVDDGEHSQ
NEKINRWNYIEGTKLFAAFFLEMAQLH

# Metabolic_Enzyme_1_Number_of_Residues:
507

# Metabolic_Enzyme_1_Molecular_Weight:
56693

# Metabolic_Enzyme_1_Theoretical_pI:
4.95

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  protein dimerization activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  metallopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_1_Pathway:
map00340  Histidine metabolism;
 map00410  beta-Alanine metabolism

# Metabolic_Enzyme_1_Reaction:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF07687:M20_dimer;
PF01546:Peptidase_M20

# Metabolic_Enzyme_1_Signals:
1-26

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.4.13.20

# Metabolic_Enzyme_1_GenBank_ID_Protein:
16555792

# Metabolic_Enzyme_1_SwissProt_ID:
CNDP1_HUMAN (Q96KN2)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
CNDP1

# Metabolic_Enzyme_1_Geneatlas_id:
CNDP1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:20675

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_1_Gene_Sequence:
>1527 bp
ATGGATCCCAAACTCGGGAGAATGGCTGCGTCCCTGCTGGCTGTGCTGCTGCTGCTGCTG
CTGGAGCGCGGCATGTTCTCCTCACCCTCCCCGCCCCCGGCGCTGTTAGAGAAAGTCTTC
CAGTACATTGACCTCCATCAGGATGAATTTGTGCAGACGCTGAAGGAGTGGGTGGCCATC
GAGAGCGACTCTGTCCAGCCTGTGCCTCGCTTCAGACAAGAGCTCTTCAGAATGATGGCC
GTGGCTGCGGACACGCTGCAGCGCCTGGGGGCCCGTGTGGCCTCGGTGGACATGGGTCCT
CAGCAGCTGCCCGATGGTCAGAGTCTTCCAATACCTCCCGTCATCCTGGCCGAACTGGGG
AGCGATCCCACGAAAGGCACCGTGTGCTTCTACGGCCACTTGGACGTGCAGCCTGCTGAC
CGGGGCGATGGGTGGCTCACGGACCCCTATGTGCTGACGGAGGTAGGCGGGAAACTTTAT
GGACGAGGAGCGACCGACAACAAAGGCCCTGTCTTGGCTTGGATCAATGCTGTGAGCGCC
TTCAGAGCCCTGGAGCAAGATCTTCCTGTGAATATCAAATTCATCATTGAGGGGATGGAA
GAGGCTGGCTCTGTTGCCCTGGAGGAACTTGTGGAAAAAGAAAAGGACCGATTCTTCTCT
GGTGTGGACTACATTGTAATTTCAGATAACCTGTGGATCAGCCAAAGGAAGCTAGCAATC
ACTTACGGAACCCGGGGGAACAGCTACTTCATGGTGGAGGTGAAATGCAGAGACCAGGAT
TTTCACTCAGGAACCTTTGGTGGCATCCTTCATGAACTAATGGCTGATCTGGTTGCTCTT
CTCGGTAGCCTGGTAGACTCGTCTGGTCATATCCTGGTCCCTGGAATCTATGATGAAGTG
GTTCCTCTTACAGAAGAGGAAATAAATACATACAAAGCCATCCATCTAGACCTAGAAGAA
TACCGGAATAGCAGCCGGGTTGAGAAATTTCTGTTCGATACTAAGGAGGAGATTCTAATG
CACCTCTGGAGGTACCCATCTCTTTCTATTCATGGGATCGAGGGCGCGTTTGATGAGCCT
GGAACTAAAACAGTCATACCTGGCCGAGTTATAGGAAAATTTTCAATCCGTCTAGTCCCT
CACATGAATGTGTCTGCGGTGGAAAAACAGGTGACACGACATCTTGAAGATGTGTTCTCC
AAAAGAAATAGTTCCAACAAGATGGTTGTTTCCATGACTCTAGGACTACACCCGTGGATT
GCAAATATTGATGACACTCAGTATCTCGCAGCAAAAAGAGCGATCAGAACAGTGTTTGGA
ACAGAACCAGATATGATCCGGGATGGATCCACCATTCCAATTGCCAAAATGTTCCAGGAG
ATCGTCCACAAGAGCGTGGTGCTAATTCCGCTGGGAGCTGTTGATGATGGAGAACATTCG
CAGAATGAGAAAATCAACAGGTGGAACTACATAGAGGGAACCAAATTATTTGCTGCCTTT
TTCTTAGAGATGGCCCAGCTCCATTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AJ417564

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:18

# Metabolic_Enzyme_1_Locus:
18q22.3

# Metabolic_Enzyme_1_SNPs:
rs4263028; rs11151964; rs9807352; rs12960862; rs2887; rs4891564; rs2346064; rs1004453; rs7239132; rs12604675; rs10469123; rs10469203; rs12607796; rs12605490; rs8087768; rs9319909; rs4892246; rs7506171; rs4329999; rs7242384; rs8085167; rs11876996; rs7244370; rs7506929; rs4892243; rs7231312; rs4892242; rs12605520; rs733686; rs9967490; rs7229005; rs7232853; rs1426256; rs7506957; rs17817095; rs11875756; rs7506825; rs17817180; rs12961730; rs12964027; rs12456406; rs12964208; rs7506760; rs12956997; rs12456388; rs12964454; rs11873844; rs17817345; rs7505047; rs17089382; rs17089414; rs17089390; rs7233066; rs9953129; rs9960024; rs11659237; rs9807248; rs11662276; rs17816861; rs11873901; rs10469124; rs17089403; rs1559809; rs17817077; rs9949100; rs4891563; rs11661606; rs2881289; rs7228575; rs9957229; rs9955944; rs17089375; rs4892244; rs17089411; rs4892239; rs17238585; rs7505555; rs12326826; rs9946796; rs11876764; rs9949990; rs34570315; rs12957330; rs7506936; rs4892241; rs7506258; rs9952652; rs4355018; rs9957885; rs11664748; rs4133234; rs17238285; rs1974965; rs11659364; rs4892238; rs11875122; rs7237549; rs9948919; rs12959707; rs12457983; rs12964810; rs1974963; rs4891562; rs11873542; rs12962343; rs2881288; rs17089378; rs12954161; rs9959794; rs7504932; rs12327522; rs11664535; rs7230673; rs12455650; rs1974964; rs7244647; rs9989559; rs11875810; rs12954438; rs2098910; rs2346061; rs2346063; rs890333; rs2346062; rs2081548; rs890332; rs11538620; rs34522443; rs11538622; rs11538624; rs11538623; rs35604255; rs10533212; rs35771415; rs34713611; rs9967349; rs33922160; rs34365714; rs34526667; rs11875787; rs28448542; rs28871039; rs35084313; rs10549931; rs10685765; rs34874693; rs4891561; rs12606902; rs34117300; rs12959038; rs36228963; rs5826336; rs35735348; rs34499247; rs35885130; rs35388041; rs28713380; rs11151965; rs34138697; rs35204551; rs9966983; rs7505007; rs35096494; rs33950634; rs33981863; rs34142328; rs12959706; rs9955580; rs9947243; rs34869467; rs35788286; rs10624462; rs34283867; rs6566813; rs34962477; rs34335073; rs5826332; rs36060345; rs34573470; rs35682790; rs35362460; rs35860275; rs35365788; rs12964034; rs10522670; rs12959748; rs4892245; rs36111704; rs12969794; rs5826335; rs4891560; rs9965945; rs34070364; rs10624665; rs5826334; rs34842524; rs35877440; rs34785330; rs17089373; rs7233122; rs10596720; rs9948674; rs34189472; rs10562152; rs10649703; rs34321505; rs35707511; rs9949211; rs35368997; rs35691581; rs35734110; rs9953867; rs34563384; rs35469246; rs8087111; rs34726849; rs35932028; rs12969795; rs12969769; rs34799288; rs35234907; rs28800835; rs34646410; rs10685766; rs34895018; rs35597919; rs12961586; rs6566814; rs28877095; rs4892240; rs33911381; rs8088199; rs11872770; rs36206459; rs7350982; rs34145828; rs11447097; rs12104001; rs4892247; rs3080879; rs10663835; rs10871736; rs10871737; rs1130046; rs11664131; rs12327049; rs12456405; rs12954579; rs12966495; rs12967519; rs12970020; rs17089369; rs2114228; rs28534519; rs35248661; rs4353545; rs4891565; rs4891566; rs4892233; rs4892248; rs4892249; rs6566815; rs7238101; rs7504377; rs7506051; rs7506112; rs8096427; rs8099458; rs9319908

# Metabolic_Enzyme_1_General_References:
12975309

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5712

# Metabolic_Enzyme_2_Name:
Ceruloplasmin precursor

# Metabolic_Enzyme_2_Synonyms:
Ferroxidase

# Metabolic_Enzyme_2_Gene_Name:
CP

# Metabolic_Enzyme_2_Protein_Sequence:
>Ceruloplasmin precursor
MKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGP
DRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFH
SHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYH
SHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYC
SEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFH
GQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKS
SSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSY
KKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGV
RFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYY
SAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMF
TTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYF
SGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRR
QSEDSTFYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYK
KVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQ
TESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVC
RRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHA
INGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFP
GTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNEDTKSG

# Metabolic_Enzyme_2_Number_of_Residues:
1065

# Metabolic_Enzyme_2_Molecular_Weight:
122206

# Metabolic_Enzyme_2_Theoretical_pI:
5.50

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_2_Specific_Function:
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing iron(II) to iron(III) without releasing radical oxygen species. It is involved in iron transport across the cell membrane

# Metabolic_Enzyme_2_Pathway:
map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_2_Reaction:
4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00394:Cu-oxidase;
PF07731:Cu-oxidase_2;
PF07732:Cu-oxidase_3

# Metabolic_Enzyme_2_Signals:
1-19

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.16.3.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
180256

# Metabolic_Enzyme_2_SwissProt_ID:
CERU_HUMAN (P00450)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
CP

# Metabolic_Enzyme_2_Geneatlas_id:
CP

# Metabolic_Enzyme_2_hgnc_id:
HGNC:2295

# Metabolic_Enzyme_2_PDB_ID:
1KCW

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_2_Gene_Sequence:
>3198 bp
ATGAAGATTTTGATACTTGGTATTTTTCTGTTTTTATGTAGTACCCCAGCCTGGGCGAAA
GAAAAGCATTATTACATTGGAATTATTGAAACGACTTGGGATTATGCCTCTGACCATGGG
GAAAAGAAACTTATTTCTGTTGACACGGAACATTCCAATATCTATCTTCAAAATGGCCCA
GATAGAATTGGGAGACTATATAAGAAGGCCCTTTATCTTCAGTACACAGATGAAACCTTT
AGGACAACTATAGAAAAACCGGTCTGGCTTGGGTTTTTAGGCCCTATTATCAAAGCTGAA
ACTGGAGATAAAGTTTATGTACACTTAAAAAACCTTGCCTCTAGGCCCTACACCTTTCAT
TCACATGGAATAACTTACTATAAGGAACATGAGGGGGCCATCTACCCTGATAACACCACA
GATTTTCAAAGAGCAGATGACAAAGTATATCCAGGAGAGCAGTATACATACATGTTGCTT
GCCACTGAAGAACAAAGTCCTGGGGAAGGAGATGGCAATTGTGTGACTAGGATTTACCAT
TCCCACATTGATGCTCCAAAAGATATTGCCTCAGGACTCATCGGACCTTTAATAATCTGT
AAAAAAGATTCTCTAGATAAAGAAAAAGAAAAACATATTGACCGAGAATTTGTGGTGATG
TTTTCTGTGGTGGATGAAAATTTCAGCTGGTACCTAGAAGACAACATTAAAACCTACTGC
TCAGAACCAGAGAAAGTTGACAAAGACAACGAAGACTTCCAGGAGAGTAACAGAATGTAT
TCTGTGAATGGATACACTTTTGGAAGTCTCCCAGGACTCTCCATGTGTGCTGAAGACAGA
GTAAAATGGTACCTTTTTGGTATGGGTAATGAAGTTGATGTGCACGCAGCTTTCTTTCAC
GGGCAAGCACTGACTAACAAGAACTACCGTATTGACACAATCAACCTCTTTCCTGCTACC
CTGTTTGATGCTTATATGGTGGCCCAGAACCCTGGAGAATGGATGCTCAGCTGTCAGAAT
CTAAACCATCTGAAAGCCGGTTTGCAAGCCTTTTTCCAGGTCCAGGAGTGTAACAAGTCT
TCATCAAAGGATAATATCCGTGGGAAGCATGTTAGACACTACTACATTGCCGCTGAGGAA
ATCATCTGGAACTATGCTCCCTCTGGTATAGACATCTTCACTAAAGAAAACTTAACAGCA
CCTGGAAGTGACTCAGCGGTGTTTTTTGAACAAGGTACCACAAGAATTGGAGGCTCTTAT
AAAAAGCTGGTTTATCGTGAGTACACAGATGCCTCCTTCACAAATCGAAAGGAGAGAGGC
CCTGAAGAAGAGCATCTTGGCATCCTGGGTCCTGTCATTTGGGCAGAGGTGGGAGACACC
ATCAGAGTAACCTTCCATAACAAAGGAGCATATCCCCTCAGTATTGAGCCGATTGGGGTG
AGATTCAATAAGAACAACGAGGGCACATACTATTCCCCAAATTACAACCCCCAGAGCAGA
AGTGTGCCTCCTTCAGCCTCCCATGTGGCACCCACAGAAACATTCACCTATGAATGGACT
GTCCCCAAAGAAGTAGGACCCACTAATGCAGATCCTGTGTGTCTAGCTAAGATGTATTAT
TCTGCTGTGGATCCCACTAAAGATATATTCACTGGGCTTATTGGGCCAATGAAAATATGC
AAGAAAGGAAGTTTACATGCAAATGGGAGACAGAAAGATGTAGACAAGGAATTCTATTTG
TTTCCTACAGTATTTGATGAGAATGAGAGTTTACTCCTGGAAGATAATATTAGAATGTTT
ACAACTGCACCTGATCAGGTGGATAAGGAAGATGAAGACTTTCAGGAATCTAATAAAATG
CACTCCATGAATGGATTCATGTATGGGAATCAGCCGGGTCTCACTATGTGCAAAGGAGAT
TCGGTCGTGTGGTACTTATTCAGCGCCGGAAATGAGGCCGATGTACATGGAATATACTTT
TCAGGAAACACATATCTGTGGAGAGGAGAACGGAGAGACACAGCAAACCTCTTCCCTCAA
ACAAGTCTTACGCTCCACATGTGGCCTGACACAGAGGGGACTTTTAATGTTGAATGCCTT
ACAACTGATCATTACACAGGCGGCATGAAGCAAAAATATACTGTGAACCAATGCAGGCGG
CAGTCTGAGGATTCCACCTTCTACCTGGGAGAGAGGACATACTATATCGCAGCAGTGGAG
GTGGAATGGGATTATTCCCCACAAAGGGAGTGGGAAAAGGAGCTGCATCATTTACAAGAG
CAGAATGTTTCAAATGCATTTTTAGATAAGGGAGAGTTTTACATAGGCTCAAAGTACAAG
AAAGTTGTGTATCGGCAGTATACTGATAGCACATTCCGTGTTCCAGTGGAGAGAAAAGCT
GAAGAAGAACATCTGGGAATTCTAGGTCCACAACTTCATGCAGATGTTGGAGACAAAGTC
AAAATTATCTTTAAAAACATGGCCACAAGGCCCTACTCAATACATGCCCATGGGGTACAA
ACAGAGAGTTCTACAGTTACTCCAACATTACCAGGTGAAACTCTCACTTACGTATGGAAA
ATCCCAGAAAGATCTGGAGCTGGAACAGAGGATTCTGCTTGTATTCCATGGGCTTATTAT
TCAACTGTGGATCAAGTTAAGGACCTCTACAGTGGATTAATTGGCCCCCTGATTGTTTGT
CGAAGACCTTACTTGAAAGTATTCAATCCCAGAAGGAAGCTGGAATTTGCCCTTCTGTTT
CTAGTTTTTGATGAGAATGAATCTTGGTACTTAGATGACAACATCAAAACATACTCTGAT
CACCCCGAGAAAGTAAACAAAGATGATGAGGAATTCATAGAAAGCAATAAAATGCATGCT
ATTAATGGAAGAATGTTTGGAAACCTACAAGGCCTCACAATGCACGTGGGAGATGAAGTC
AACTGGTATCTGATGGGAATGGGCAATGAAATAGACTTACACACTGTACATTTTCACGGC
CATAGCTTCCAATACAAGCACAGGGGAGTTTATAGTTCTGATGTCTTTGACATTTTCCCT
GGAACATACCAAACCCTAGAAATGTTTCCAAGAACACCTGGAATTTGGTTACTCCACTGC
CATGTGACCGACCACATTCATGCTGGAATGGAAACCACTTACACCGTTCTACAAAATGAA
GACACCAAATCTGGCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M13699

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_2_Locus:
3q23-q25

# Metabolic_Enzyme_2_SNPs:
rs34624984; rs701753; rs1053709; rs34237139; rs34394958; rs35438054; rs9834971; rs1523514; rs6799507; rs772908; rs12496866; rs6768350; rs1523513; rs4974389; rs11917114; rs701755; rs3107836; rs34004251; rs16861576; rs11919626; rs16861598; rs1879169; rs16861602; rs16861633; rs6440590; rs11922514; rs16861593; rs773050; rs16861577; rs35284835; rs16861582; rs34171195; rs3736282; rs16861590; rs16861588; rs7632958; rs16861634; rs11714000; rs11924891; rs17847023; rs34951015; rs10935743; rs11921705; rs3816893; rs11709714; rs34865491; rs16861579; rs17787768; rs7632964; rs16861637; rs11924961; rs16861596; rs701751; rs3765125; rs701754; rs10935742; rs7652826; rs9853335; rs6792209; rs34861155; rs11915834; rs1523515; rs9841442; rs35593818; rs35610536; rs34481162; rs34300334; rs35903829; rs2681084; rs13072552; rs34175628; rs13092519; rs13095262; rs34626625; rs35191080; rs36074020; rs696994; rs772904; rs34079352; rs36021368; rs35229573; rs35966950; rs34013572; rs36098024; rs35773127; rs35386382; rs35876747; rs34649438; rs36106034; rs34443048; rs34656703; rs35716500; rs35272481; rs34067682; rs34042451; rs35899708; rs35378125; rs34842353; rs35653745; rs35123935; rs1908053; rs35165738; rs34930306; rs34650204; rs34052330; rs34617132; rs798842; rs35727759; rs35062355; rs34654392; rs1879168; rs35767691; rs34770768; rs16861639; rs13075891; rs34010341; rs34535555; rs34011114; rs35529745; rs34335440; rs13084448; rs34335607; rs11710581; rs34867923; rs35541542; rs34504513; rs34454179; rs36103494; rs36099841; rs35244189; rs34586382; rs16861636; rs13075921; rs34823342; rs13080467; rs35216818; rs34753475; rs34296476; rs772907; rs35334247; rs11288866; rs35516209; rs34907627; rs34670346; rs34091282; rs7634054; rs34645589; rs34516709; rs34312834; rs35848147; rs35198307; rs35976863; rs35090057; rs10935744; rs35364670; rs34049286; rs7632719; rs34155161; rs35904683; rs36027953; rs35718216; rs35503313; rs34142100; rs35358026; rs809554; rs34414552; rs34751274; rs35149808; rs35048481; rs701748; rs3755644; rs696993; rs701749; rs35682120; rs17838832; rs36024032; rs35691438; rs17838831; rs35622518; rs35474921; rs17838834; rs34851340; rs17838833; rs17847018; rs11553309; rs2681095; rs35331711; rs2640038; rs34386552; rs17847026; rs34987997; rs17847022; rs17847025; rs13314294; rs1063899; rs17847016; rs11553308; rs35142039; rs35334652; rs9833860; rs13080302; rs10540828; rs34817492; rs2681098; rs35103260; rs11920882; rs12107157; rs35879864; rs798841; rs34855818; rs35885078; rs17847019; rs28722677; rs701750; rs34399626; rs35132881; rs3103861; rs35551942; rs35238123; rs2933882; rs2640037; rs2681094; rs28657647; rs34861029; rs2640042; rs7623387; rs28361508; rs35019965; rs36103142; rs811635; rs6767930; rs10718513; rs13062843; rs9833659; rs34251410; rs9653952; rs809553; rs35465173; rs11926259; rs2681099; rs35766301; rs34321384; rs35942827; rs34375295; rs10663585; rs34372049; rs34929084; rs2681083; rs34355891; rs35721007; rs4974392; rs35900668; rs41267873; rs34841236; rs34145911; rs11451281; rs34568785; rs34757057; rs34750070; rs17847028; rs34113826; rs2640039; rs12487772; rs11380808; rs2933883; rs2933884; rs35193625; rs35236994; rs35752872; rs2681080; rs810089; rs35652604; rs34875136; rs10573853; rs10631065; rs35048131; rs35288810; rs34437667; rs13091064; rs34556731; rs35102207; rs9821640; rs34700374; rs34230520; rs34241019; rs10576836; rs34686915; rs3736520; rs701757; rs2946680; rs34895769; rs35927352; rs2640044; rs35196125; rs34550573; rs35076221; rs772906; rs34343199; rs34696248; rs35850459; rs35090033; rs35204894; rs34636664; rs701752; rs13079008; rs34445333; rs35267205; rs34315195; rs34873592; rs9857073; rs35360246; rs2681100; rs34016079; rs35335199; rs2640041; rs35974775; rs34523231; rs34832681; rs2681097; rs13091078; rs2681086; rs34171193; rs35682875; rs10661618; rs2971562; rs34575419; rs810088; rs35387181; rs34239280; rs3070607; rs35855023; rs17847024; rs36107315; rs17847017; rs2640043; rs35913214; rs2681082; rs6777849; rs34003547; rs34938986; rs11374895; rs11309557; rs34618068; rs11347585; rs35972521; rs34587777; rs701756; rs2933885; rs2681093; rs35886571; rs2640040; rs35068918; rs13068416; rs34168096; rs28390156; rs34571365; rs28408096; rs36074830; rs13068197; rs35937468; rs35816853; rs35358355; rs11288867; rs812829; rs36036828; rs35296558; rs2681085; rs34510606; rs34053109; rs35633059; rs34334174; rs34109328; rs34110798; rs11708215; rs11720427; rs12494334; rs13066364; rs13095764; rs13096289; rs13098532; rs16846602; rs16861642; rs16861645; rs16861646; rs16861647; rs16861649; rs17195505; rs2177392; rs2681092; rs2681096; rs2681101; rs2981470; rs2981471; rs34060990; rs35196849; rs35355363; rs35371359; rs35555422; rs3732557; rs3755641; rs3755642; rs4681170; rs4681490; rs7623663; rs9877778

# Metabolic_Enzyme_2_General_References:
2873574; 7702601; 3755405; 3486416; 6582496; 6571985; 6940148; 6987229; 6987230; 2355023; 12055353

# Metabolic_Enzyme_2_References:
11911459; 12132593

# Metabolic_Enzyme_3_ID:
6878

# Metabolic_Enzyme_3_Name:
Catalase

# Metabolic_Enzyme_3_Synonyms:
Not Available

# Metabolic_Enzyme_3_Gene_Name:
CAT

# Metabolic_Enzyme_3_Protein_Sequence:
>Catalase
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT
KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD
THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE
HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK
NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL

# Metabolic_Enzyme_3_Number_of_Residues:
527

# Metabolic_Enzyme_3_Molecular_Weight:
59757

# Metabolic_Enzyme_3_Theoretical_pI:
7.41

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  catalase activity
 ||
>>>
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide

# Metabolic_Enzyme_3_Pathway:
map00380  Tryptophan metabolism;
 map00680  Methane metabolism

# Metabolic_Enzyme_3_Reaction:
2 H2O2 = O2 + 2 H2O

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00199:Catalase

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.11.1.6

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1228085

# Metabolic_Enzyme_3_SwissProt_ID:
CATA_HUMAN (P04040)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
CAT

# Metabolic_Enzyme_3_Geneatlas_id:
CAT

# Metabolic_Enzyme_3_hgnc_id:
HGNC:1516

# Metabolic_Enzyme_3_PDB_ID:
1F4J

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_3_Gene_Sequence:
>66 bp
ATGGCTGACAGCCGGGATCCCGCCAGCGACCAGATGCAGCACTGGAAGGAGCAGCGGGCC
GCGCAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X04085

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_3_Locus:
11p13

# Metabolic_Enzyme_3_SNPs:
rs17880442; rs11032709; rs769217; rs35677492; rs1049982; rs2234940; rs1050032; rs566979; rs769218; rs511895; rs524167; rs494024; rs1408035; rs560807; rs10488736; rs2284367; rs482322; rs7947841; rs480496; rs11032699; rs2300182; rs2284365; rs7103083; rs499406; rs3758730; rs4755372; rs508370; rs7933285; rs1000343; rs554576; rs2073059; rs11032701; rs17886008; rs4755373; rs484214; rs6484722; rs543701; rs17884666; rs2420389; rs551929; rs480575; rs10836244; rs2179625; rs7113917; rs2268063; rs533425; rs12272630; rs17881488; rs486256; rs17884576; rs2073058; rs11604331; rs17884491; rs7120960; rs1408034; rs524154; rs7109778; rs7101395; rs17881288; rs12269988; rs7126610; rs10836235; rs16925608; rs16925614; rs11824384; rs2284368; rs17883121; rs2420388; rs4756146; rs16925606; rs17884086; rs2284364; rs7930427; rs12803540; rs1408036; rs17268652; rs2284366; rs17881567; rs2300181; rs7928213; rs11032702; rs16925581; rs525938; rs11032700; rs17881921; rs17884095; rs17885743; rs17881476; rs17883793; rs11826620; rs12270780; rs35915891; rs2268064; rs17883592; rs17884725; rs17881482; rs17880673; rs2284369; rs17883544; rs11032703; rs12273124; rs17884248; rs35755143; rs7126640; rs2076556; rs4755374; rs1055981; rs17884335; rs17884518; rs17880274; rs17883699; rs4756148; rs17886200; rs475043; rs564250; rs769214; rs9282626; rs7943316; rs9282627; rs7104301; rs17883920; rs1001179; rs17881029; rs17886350; rs2266625; rs34455645; rs3180560; rs11546300; rs1050028; rs2266629; rs2266619; rs14527; rs2266628; rs35012776; rs34964953; rs34727149; rs3831770; rs17886810; rs35927227; rs7121850; rs17885881; rs17882812; rs17885837; rs17880607; rs17882039; rs17881916; rs17880549; rs34138762; rs28586982; rs34503767; rs36074933; rs515130; rs35099202; rs35849009; rs17881846; rs17887048; rs17881224; rs17884421; rs34840731; rs17881231; rs35340649; rs35292563; rs17884242; rs12286702; rs35034960; rs28733253; rs17887248; rs35791482; rs35703808; rs35648206; rs34808995; rs35386961; rs34420404; rs856714; rs17883483; rs17884804; rs17883367; rs17883534; rs17880160; rs17886672; rs34281397; rs34790990; rs2982523; rs35122257; rs2284370; rs12798927; rs35781217; rs11032707; rs17886592; rs4483566; rs34890123; rs4272763; rs12789374; rs17881734; rs35330036; rs17883434; rs35081167; rs17886155; rs17886248; rs34840787; rs34890990; rs17881192; rs17881586; rs34267165; rs12786539; rs35834969; rs3818354; rs17884443; rs36224415; rs36224416; rs36224102; rs10312; rs10836230; rs10836233; rs10836234; rs11032717; rs1107573; rs11606946; rs12284341; rs12807961; rs12808450; rs1323690; rs1535718; rs1535719; rs1535720; rs1535721; rs16925525; rs2073057; rs208678; rs208679; rs208681; rs208682; rs208683; rs2231828; rs2266624; rs2266630; rs2296144; rs409598; rs554518; rs7109862; rs7114869; rs7118388; rs7928156; rs7941147; rs7944397; rs7949972

# Metabolic_Enzyme_3_General_References:
3755525; 3755526; 11728823; 8282800; 12665801; 6548744; 10666617; 10656833; 11134921

# Metabolic_Enzyme_3_References:
15878720; 16100910; 8312381; 8608175

# Metabolic_Enzyme_4_ID:
7375

# Metabolic_Enzyme_4_Name:
Superoxide dismutase [Mn], mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
Not Available

# Metabolic_Enzyme_4_Gene_Name:
SOD2

# Metabolic_Enzyme_4_Protein_Sequence:
>Superoxide dismutase Mn, mitochondrial precursor
MLSRAVCGTSRQLAPALGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVN
NLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEA
IKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLL
GIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK

# Metabolic_Enzyme_4_Number_of_Residues:
222

# Metabolic_Enzyme_4_Molecular_Weight:
24722

# Metabolic_Enzyme_4_Theoretical_pI:
8.45

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  metal ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on superoxide radicals as acceptor
Function:  superoxide dismutase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  superoxide metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems

# Metabolic_Enzyme_4_Pathway:
Not Available

# Metabolic_Enzyme_4_Reaction:
2 O2*- + 2 H+ = O2 + H2O2

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF02777:Sod_Fe_C;
PF00081:Sod_Fe_N

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.15.1.1

# Metabolic_Enzyme_4_GenBank_ID_Protein:
34709

# Metabolic_Enzyme_4_SwissProt_ID:
SODM_HUMAN (P04179)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
SOD2

# Metabolic_Enzyme_4_Geneatlas_id:
SOD2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:11180

# Metabolic_Enzyme_4_PDB_ID:
1LUV

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_4_Gene_Sequence:
>669 bp
ATGTTGAGCCGGGCAGTGTGCGGCACCAGCAGGCAGCTGGCTCCGGCTTTGGGGTATCTG
GGCTCCAGGCAGAAGCACAGCCTCCCCGACCTGCCCTACGACTACGGCGCCCTGGAACCT
CACATCAACGCGCAGATCATGCAGCTGCACCACAGCAAGCACCACGCGGCCTACGTGAAC
AACCTGAACGTCAACGAGGAGAAGTACCAGGAGGCGTTGGCCAAGGGAGATGTTACAGCC
CAGATAGCTCTTCAGCCTGCACTGAAGTTCAATGGTGGTGGTCATATCAATCATAGCATT
TTCTGGACAAACCTCAGCCCTAACGGTGGTGGAGAACCCAAAGGGGAGTTGCTGGAAGCC
ATCAAACGTGACTTTGGTTCCTTTGACAAGTTTAAGGAGAAGCTGACGGCTGCATCTGTT
GGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAACGGGGACACTTACAA
ATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTG
GGGATTGATGTGTGGGAGCACGCTTACTACCTTCAGTATAAAAATGTCAGGCCTGATTAT
CTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAAGATACATGGCTTGC
AAAAAGTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
X59445

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_4_Locus:
6q25.3

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
2462451; 3684581; 3399391; 2831093; 1988135; 1699607; 7702755; 14574404; 6386798; 7895732; 7498159; 9150946; 1394426; 8605177; 9537988; 9537987; 10852710; 11580280

# Metabolic_Enzyme_4_References:
10564779; 11866117; 11985892; 1649087

# Metabolic_Enzyme_5_ID:
5515

# Metabolic_Enzyme_5_Name:
Aspartate aminotransferase, cytoplasmic

# Metabolic_Enzyme_5_Synonyms:
Transaminase A; Glutamate oxaloacetate transaminase 1

# Metabolic_Enzyme_5_Gene_Name:
GOT1

# Metabolic_Enzyme_5_Protein_Sequence:
>Aspartate aminotransferase, cytoplasmic
MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQK
IANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFL
ARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLEN
APEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWA
IRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPP
AQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGM
FSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ

# Metabolic_Enzyme_5_Number_of_Residues:
413

# Metabolic_Enzyme_5_Molecular_Weight:
46248

# Metabolic_Enzyme_5_Theoretical_pI:
7.01

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  transaminase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_5_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00272  Cysteine metabolism;
 map00330  Arginine and proline metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00401  Novobiocin biosynthesis;
 map00710  Carbon fixation;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_5_Reaction:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.6.1.1

# Metabolic_Enzyme_5_GenBank_ID_Protein:
179067

# Metabolic_Enzyme_5_SwissProt_ID:
AATC_HUMAN (P17174)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
GOT1

# Metabolic_Enzyme_5_Geneatlas_id:
GOT1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:4432

# Metabolic_Enzyme_5_PDB_ID:
1AJS

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1242 bp
ATGGCACCTCCGTCAGTCTTTGCCGAGGTTCCGCAGGCCCAGCCTGTCCTGGTCTTCAAG
CTCACTGCCGACTTCAGGGAGGATCCGGACCCCCGCAAGGTCAACCTGGGAGTGGGAGCA
TATCGCACGGATGACTGCCATCCCTGGGTTTTGCCAGTAGTGAAGAAAGTGGAGCAGAAG
ATTGCTAATGACAATAGCCTAAATCACGAGTATCTGCCAATCCTGGGCCTGGCTGAGTTC
CGGAGCTGTGCTTCTCGTCTTGCCCTTGGGGATGACAGCCCAGCACTCAAGGAGAAGCGG
GTAGGAGGTGTGCAATCTTTGGGGGGAACAGGTGCACTTCGAATTGGAGCTGATTTCTTA
GCGCGTTGGTACAATGGAACAAACAACAAGAACACACCTGTCTATGTGTCCTCACCAACC
TGGGAGAATCACAATGCTGTGTTTTCCGCTGCTGGTTTTAAAGACATTCGGTCCTATCGC
TACTGGGATGCAGAGAAGAGAGGATTGGACCTCCAGGGCTTCCTGAATGATCTGGAGAAT
GCTCCTGAGTTCTCCATTGTTGTCCTCCACGCCTGTGCACACAACCCAACTGGGATTGAC
CCAACTCCGGAGCAGTGGAAGCAGATTGCTTCTGTCATGAAGCACCGGTTTCTGTTCCCC
TTCTTTGACTCAGCCTATCAGGGCTTCGCATCTGGAAACCTGGAGAGAGATGCCTGGGCC
ATTCGCTATTTTGTGTCTGAAGGCTTCGAGTTCTTCTGTGCCCAGTCCTTCTCCAAGAAC
TTCGGGCTCTACAATGAGAGAGTCGGGAATCTGACTGTGGTTGGAAAAGAACCTGAGAGC
ATCCTGCAAGTCCTTTCCCAGATGGAGAAGATCGTGCGGATTACTTGGTCCAATCCCCCC
GCCCAGGGAGCACGAATTGTGGCCAGCACCCTCTCTAACCCTGAGCTCTTTGAGGAATGG
ACAGGTAATGTGAAGACAATGGCTGACCGGATTCTGACCATGAGATCTGAACTCAGGGCA
CGACTAGAAGCCCTCAAAACCCCTGGGACCTGGAACCACATCACTGATCAAATTGGCATG
TTCAGCTTCACTGGGTTGAACCCCAAGCAGGTTGAGTATCTGGTCAATGAAAAGCACATC
TACCTGCTGCCAAGTGGTCGAATCAACGTGAGTGGCTTAACCACCAAAAATCTAGATTAC
GTGGCCACCTCCATCCATGAAGCAGTCACCAAAATCCAGTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M37400

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_5_Locus:
10q24.1-q25.1

# Metabolic_Enzyme_5_SNPs:
rs2234971; rs2641; rs11867; rs1126878; rs11190083; rs2862611; rs4328160; rs4919310; rs11813054; rs3793935; rs4919308; rs17111658; rs3750897; rs2275952; rs7906501; rs7918062; rs7067702; rs9971275; rs9971274; rs11190087; rs11594790; rs12571181; rs12249347; rs10883343; rs11819158; rs4353208; rs3763793; rs11190088; rs17569447; rs3793933; rs7921465; rs12253915; rs3793934; rs2494651; rs10883341; rs2862612; rs2490280; rs12768505; rs17111665; rs2862613; rs17569578; rs4567385; rs11815136; rs10883342; rs10748775; rs4919309; rs17491012; rs12253861; rs11190081; rs2862614; rs12217584; rs11815637; rs12766044; rs17111645; rs17111694; rs4919311; rs12411568; rs11557841; rs4564264; rs41290500; rs11557840; rs1126927; rs11190082; rs2642; rs1802509; rs1802508; rs41290498; rs34854950; rs12777843; rs35687189; rs11394746; rs34971146; rs34646712; rs35478605; rs34582301; rs3045656; rs12252840; rs35736782; rs11378738; rs7918037; rs41400447; rs7896693; rs5787336; rs9731375; rs35003844; rs11456562; rs11313874; rs12358477; rs10668892; rs12241455; rs41436049; rs5787337; rs9971276; rs35500142; rs35096443; rs11456561; rs2902275; rs7899976; rs13377085; rs12777646; rs10629267; rs12414885; rs35193236; rs11325628; rs12777641; rs34254460; rs1892505; rs12776735; rs12776369; rs4917866; rs12775973; rs11816599; rs6584274; rs33928164; rs10786543; rs7917808; rs11429814; rs35546038; rs10716499; rs35665184; rs11190090; rs34122561; rs2234894; rs10748774; rs10786545; rs11190080; rs11190094; rs1132364; rs11592057; rs11598504; rs17111699; rs17490682; rs2298315; rs2298316; rs2490281; rs2490283; rs2494652; rs2494653; rs2494654; rs2862610; rs34183428; rs3750896; rs3793931; rs3793932; rs4345898; rs4917862; rs4917864; rs4919307; rs7099391; rs7914408; rs7920356

# Metabolic_Enzyme_5_General_References:
1974457; 2241899

# Metabolic_Enzyme_5_References:
10447557; 10789500; 15234195

# Macromolecular_Interacting_Partner_1_ID:
6352

# Macromolecular_Interacting_Partner_1_Name:
Atrial natriuretic peptide receptor B precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
ANP-B; ANPRB; GC-B; Guanylate cyclase B; NPR-B; Atrial natriuretic peptide B-type receptor

# Macromolecular_Interacting_Partner_1_Gene_Name:
NPR2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Atrial natriuretic peptide receptor B precursor
MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRAL
PVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLL
TAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPH
YFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQA
QRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYRE
PPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTRED
GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW
TGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRK
LMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANT
GHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCP
RGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKI
TDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALR
SGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFG
QIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPH
SVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNF
DVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGV
HTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELR
GDVEMKGKGKMRTYWLLGERKGPPGLL

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
1047

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
117024

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.86

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  peptide receptor activity, G-protein coupled
Function:  catalytic activity
Function:  lyase activity
Function:  phosphorus-oxygen lyase activity
 ||
>>>
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  cyclic nucleotide biosynthesis
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Signal transduction mechanisms 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Receptor for atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). Has guanylate cyclase activity on binding of ligand. The activation order seems to be CNP > BNP > ANP

# Macromolecular_Interacting_Partner_1_Pathway:
map00230  Purine metabolism

# Macromolecular_Interacting_Partner_1_Reaction:
GTP = 3',5'-cyclic GMP + diphosphate

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01094:ANF_receptor;
PF00211:Guanylate_cyc;
PF00069:Pkinase

# Macromolecular_Interacting_Partner_1_Signals:
1-22

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
459-478

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 4.6.1.2

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
5139790

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
ANPRB_HUMAN (P20594)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
NPR2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
NPR2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:7944

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>3144 bp
ATGGCGCTGCCATCACTTCTGCTGTTGGTGGCAGCCCTGGCAGGTGGGGTGCGTCCTCCC
GGGGCGCGGAACCTGACGCTGGCGGTGGTGCTGCCAGAACACAACCTGAGCTATGCCTGG
GCCTGGCCACGGGTGGGACCCGCTGTGGCACTAGCTGTGGAGGCTCTGGGCCGGGCACTG
CCCGTGGACCTGCGGTTTGTCAGCTCCGAACTGGAAGGCGCCTGCTCTGAGTACCTGGCA
CCGCTGAGCGCTGTGGACCTCAAGCTGTACCATGACCCCGACCTGCTGTTAGGTCCCGGT
TGCGTGTACCCTGCTGCCTCTGTGGCCCGCTTTGCCTCCCACTGGCGCCTTCCCCTGCTG
ACTGCGGGTGCTGTGGCCTCTGGTTTTTCGGCTAAGAATGACCATTATCGTACCCTGGTT
CGCACTGGCCCCTCTGCTCCCAAGCTGGGTGAGTTTGTGGTGACACTACACGGGCACTTC
AATTGGACTGCCCGTGCTGCCTTGCTGTACCTGGATGCTCGCACAGATGACCGGCCTCAC
TACTTCACCATCGAGGGCGTCTTTGAGGCCCTGCAGGGCAGCAACCTCAGTGTGCAGCAC
CAGGTGTATGCCCGAGAGCCAGGGGGCCCCGAGCAGGCCACCCACTTCATCCGGGCCAAC
GGGCGCATTGTGTATATCTGCGGCCCTCTGGAGATGCTGCATGAGATCCTGCTTCAGGCC
CAGAGGGAGAATCTGACCAATGGGGATTATGTCTTCTTTTACCTGGATGTCTTTGGGGAG
AGTCTCCGTGCAGGCCCCACACGTGCTACAGGCCGGCCCTGGCAGGACAATCGCACCCGG
GAACAGGCCCAGGCCCTCAGAGAGGCCTTTCAGACTGTATTGGTGATCACGTACCGAGAA
CCCCCAAATCCTGAGTATCAGGAATTCCAGAATCGTCTGCTGATAAGAGCCCGGGAAGAC
TTTGGTGTGGAGCTGGGCCCTTCCCTGATGAACCTCATCGCTGGCTGCTTCTATGATGGG
ATCCTGCTATATGCTGAAGTCCTGAATGAGACAATACAGGAAGGAGGCACCCGGGAGGAT
GGACTTCGAATTGTGGAAAAGATGCAGGGACGAAGATATCACGGTGTAACTGGGCTGGTT
GTCATGGACAAGAACAATGACCGAGAGACTGACTTTGTCCTCTGGGCCATGGGAGACCTG
GATTCTGGGGACTTTCAGCCTGCAGCCCACTACTCGGGAGCTGAGAAGCAGATTTGGTGG
ACGGGACGGCCTATTCCCTGGGTGAAGGGGGCTCCTCCCTCGGACAATCCCCCCTGTGCC
TTTGACTTGGACGACCCATCCTGTGATAAAACTCCACTTTCAACCCTGGCAATTGTGGCT
CTGGGCACAGGAATCACCTTCATCATGTTTGGTGTTTCCAGCTTCCTAATTTTCCGAAAG
CTGATGCTGGAGAAGGAGCTGGCTAGCATGTTGTGGCGTATTCGCTGGGAAGAACTGCAG
TTTGGCAACTCAGAGCGTTATCACAAAGGTGCAGGCAGTCGCCTCACACTGTCGCTGCGG
GGATCCAGTTACGGCTCGCTCATGACAGCCCATGGGAAATACCAGATCTTTGCCAACACC
GGTCACTTCAAGGGAAATGTTGTCGCCATCAAACATGTGAATAAGAAGCGCATTGAGCTG
ACCCGGCAGGTTCTGTTTGAACTCAAACATATGAGAGATGTTCAGTTCAACCATCTCACT
CGCTTCATTGGCGCCTGCATAGACCCTCCCAACATTTGCATTGTCACTGAATACTGTCCT
CGTGGGAGTTTACAGGATATTCTAGAAAATGACAGCATCAACTTGGACTGGATGTTTCGT
TATTCACTCATTAATGACCTTGTTAAGGGCATGGCCTTTCTCCACAACAGCATTATTTCA
TCGCATGGGAGTCTCAAGTCCTCCAACTGTGTGGTGGATAGTCGTTTTGTGCTCAAAATC
ACAGACTATGGCCTGGCCAGCTTCCGATCAACTGCTGAACCTGATGACAGCCATGCCCTC
TATGCCAAGAAGCTGTGGACTGCCCCAGAACTGCTCAGTGGGAACCCCTTGCCAACCACA
GGCATGCAGAAGGCTGACGTCTATAGCTTTGGGATCATCCTGCAGGAGATAGCACTTCGC
AGTGGTCCTTTCTACTTGGAGGGCCTGGACCTCAGCCCCAAAGAGATTGTCCAGAAGGTA
CGAAATGGTCAGCGGCCATATTTCCGGCCAAGCATTGACCGGTCCCAACTGAATGAAGAG
CTAGTTTTGCTGATGGAGCGATGTTGGGCTCAGGACCCAGCTGAGCGGCCAGACTTTGGA
CAGATTAAGGGCTTCATTCGGCGCTTTAACAAGGAGGGTGGCACCAGCATATTGGACAAC
CTCCTGCTGCGCATGGAACAGTATGCCAATAACTTGGAGAAGCTGGTGGAGGAACGCACA
CAGGCCTATCTGGAGGAAAAACGCAAGGCTGAAGCTCTGCTCTACCAAATCCTACCCCAT
TCAGTGGCAGAGCAGTTAAAACGGGGAGAGACTGTACAGGCTGAGGCCTTTGACAGTGTT
ACCATCTACTTCAGTGACATTGTTGGCTTCACAGCATTGTCAGCAGAGAGCACCCCCATG
CAGGTAGTGACACTTCTTAATGACCTGTATACCTGCTTTGATGCCATAATTGACAACTTT
GATGTCTACAAGGTGGAGACGATTGGGGATGCTTACATGGTGGTATCTGGCCTCCCAGGC
CGAAATGGTCAACGCCATGCACCAGAAATTGCTCGTATGGCCCTAGCATTACTAGATGCA
GTTTCTTCCTTTCGCATCCGCCACCGACCCCATGACCAGCTGAGGCTACGCATAGGGGTC
CATACTGGGCCAGTCTGTGCTGGGGTTGTTGGCCTGAAGATGCCCCGTTATTGTCTTTTT
GGAGACACAGTGAACACTGCTTCTCGAATGGAGTCTAATGGTCAAGCGCTGAAGATCCAT
GTCTCCTCTACCACCAAGGATGCCCTAGATGAGCTAGGATGCTTCCAGCTAGAGCTTCGG
GGGGATGTGGAAATGAAGGGAAAAGGAAAGATGCGAACATACTGGCTCTTAGGAGAGCGG
AAAGGACCTCCTGGACTCCTGTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AB005647

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_1_Locus:
9p21-p12

# Macromolecular_Interacting_Partner_1_SNPs:
rs2228580; rs5812; rs7043647; rs10758325; rs10814276; rs1322044; rs7034957; rs3793543; rs7021716; rs7031237; rs7864199; rs1407295; rs2236290; rs2236289; rs2890702; rs13288085; rs1078081; rs10758324; rs12347878; rs12553111; rs5816; rs28931581; rs28929479; rs3729731; rs3729730; rs28931582; rs5813; rs28764009; rs5815; rs4512468; rs5024028; rs13293624; rs28764011; rs34474231; rs28764014; rs4879927; rs10603903; rs35323702; rs12005446; rs35457827; rs12686421; rs34532812; rs28764012; rs3069788; rs11328092; rs35713408; rs35484064; rs1407296; rs28764008; rs1322043; rs35170845; rs28764010; rs35145770; rs28764013; rs34349173; rs3750438; rs3842217; rs34754193; rs10972585; rs35743544; rs10758323; rs10972591; rs12337802; rs12338156; rs12342037; rs13292880; rs13294264; rs13294295; rs13299765; rs2145923; rs2281645; rs2281646; rs3763631; rs3808864; rs3808865; rs4879928; rs4879929; rs6476491; rs7848310; rs7866903; rs7873145; rs878749; rs878750

# Macromolecular_Interacting_Partner_1_General_References:
2570358; 10082481; 10073597

# Macromolecular_Interacting_Partner_1_References:
1353937; 1361362; 1981669; 7910045

# Macromolecular_Interacting_Partner_2_ID:
7803

# Macromolecular_Interacting_Partner_2_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_2_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_2_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_2_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_2_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_2_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_2_References:
1334706; 4253964; 6331862; 9461633

# Macromolecular_Interacting_Partner_3_ID:
8254

# Macromolecular_Interacting_Partner_3_Name:
Oligopeptide transporter, small intestine isoform

# Macromolecular_Interacting_Partner_3_Synonyms:
Peptide transporter 1; Intestinal H(+/peptide cotransporter; Solute carrier family 15 member 1

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC15A1

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Oligopeptide transporter, small intestine isoform
MGMSKSHSFFGYPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDDNLSTAIYHTFV
ALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVTSVSSINDLTDHNHDGTPDSLPV
HVVLSLIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGSLLSTII
TPMLRVQQCGIHSKQACYPLAFGVPAALMAVALIVFVLGSGMYKKFKPQGNIMGKVAKCI
GFAIKNRFRHRSKAFPKREHWLDWAKEKYDERLISQIKMVTRVMFLYIPLPMFWALFDQQ
GSRWTLQATTMSGKIGALEIQPDQMQTVNAILIVIMVPIFDAVLYPLIAKCGFNFTSLKK
MAVGMVLASMAFVVAAIVQVEIDKTLPVFPKGNEVQIKVLNIGNNTMNISLPGEMVTLGP
MSQTNAFMTFDVNKLTRINISSPGSPVTAVTDDFKQGQRHTLLVWAPNHYQVVKDGLNQK
PEKGENGIRFVNTFNELITITMSGKVYANISSYNASTYQFFPSGIKGFTISSTEIPPQCQ
PNFNTFYLEFGSAYTYIVQRKNDSCPEVKVFEDISANTVNMALQIPQYFLLTCGEVVFSV
TGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAGAGQFSKQWAEYILFAALLLVVC
VIFAIMARFYTYINPAEIEAQFDEDEKKNRLEKSNPYFMSGANSQKQM

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
708

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
78807

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
8.64

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  transporter activity
Function:  peptide transporter activity
Function:  oligopeptide transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  peptide transport
Process:  oligopeptide transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_3_Specific_Function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00854:PTR2

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
1-21
54-74
83-103
119-139
162-182
199-219
277-297
328-348
362-382
585-605
620-640
646-666

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
773588

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
S15A1_HUMAN (P46059)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC15A1

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC15A1

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:10920

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>2127 bp
ATGGGAATGTCCAAATCACACAGTTTCTTTGGTTATCCCCTGAGCATCTTCTTCATCGTG
GTCAATGAGTTTTGCGAAAGATTTTCCTACTATGGAATGCGAGCAATCCTGATTCTGTAC
TTCACAAATTTCATCAGCTGGGATGATAACCTGTCCACCGCCATCTACCATACGTTTGTG
GCTCTGTGCTACCTGACGCCAATTCTCGGAGCTCTTATCGCCGACTCGTGGCTGGGAAAG
TTCAAGACCATTGTGTCGCTCTCCATTGTCTACACAATTGGACAAGCAGTCACCTCAGTA
AGCTCCATTAATGACCTCACAGACCACAACCATGATGGCACCCCCGACAGCCTTCCTGTG
CACGTGGTGCTGTCCTTGATCGGCCTGGCCCTGATAGCTCTCGGGACTGGAGGAATCAAA
CCCTGTGTGTCTGCGTTTGGTGGAGATCAGTTTGAAGAGGGCCAGGAGAAACAAAGAAAC
AGATTTTTTTCCATCTTTTACTTGGCTATTAATGCTGGAAGTTTGCTTTCCACAATCATC
ACACCCATGCTCAGAGTTCAACAATGTGGAATTCACAGTAAACAAGCTTGTTACCCACTG
GCCTTTGGGGTTCCTGCTGCTCTCATGGCTGTAGCCCTGATTGTGTTTGTCCTTGGCAGT
GGGATGTACAAGAAGTTCAAGCCACAGGGCAACATCATGGGTAAAGTGGCCAAGTGCATC
GGTTTTGCCATCAAAAATAGATTTAGGCATCGGAGTAAGGCATTTCCCAAGAGGGAGCAC
TGGCTGGACTGGGCTAAAGAGAAATACGATGAGCGGCTCATCTCCCAAATTAAGATGGTT
ACGAGGGTGATGTTCCTGTATATTCCACTCCCAATGTTCTGGGCCTTGTTTGACCAGCAG
GGCTCCAGGTGGACACTGCAGGCAACAACTATGTCCGGGAAAATCGGAGCTCTTGAAATT
CAGCCCGATCAGATGCAGACCGTGAACGCCATCCTGATCGTGATCATGGTCCCGATCTTC
GATGCTGTGCTGTACCCTCTCATTGCAAAATGTGGCTTCAATTTCACCTCCTTGAAGAAG
ATGGCAGTTGGCATGGTCCTGGCCTCCATGGCCTTTGTGGTGGCTGCCATCGTGCAGGTG
GAAATCGATAAAACTCTTCCAGTCTTCCCCAAAGGAAACGAAGTCCAAATTAAAGTTTTG
AATATAGGAAACAATACCATGAATATATCTCTTCCTGGAGAGATGGTGACACTTGGCCCA
ATGTCTCAAACAAATGCATTTATGACTTTTGATGTAAACAAACTGACAAGGATAAACATT
TCTTCTCCTGGATCACCAGTCACTGCTGTAACTGACGACTTCAAGCAGGGCCAACGCCAC
ACGCTTCTAGTGTGGGCCCCCAATCACTACCAGGTGGTAAAGGATGGTCTTAACCAGAAG
CCAGAAAAAGGGGAAAATGGAATCAGATTTGTAAATACTTTTAACGAGCTCATCACCATC
ACAATGAGTGGGAAAGTTTATGCAAACATCAGCAGCTACAATGCCAGCACATACCAGTTT
TTTCCTTCTGGCATAAAAGGCTTCACAATAAGCTCAACAGAGATTCCGCCACAATGTCAA
CCTAATTTCAATACTTTCTACCTTGAATTTGGTAGTGCTTATACCTATATAGTCCAAAGG
AAGAATGACAGCTGCCCTGAAGTGAAGGTGTTTGAAGATATTTCAGCCAACACAGTTAAC
ATGGCTCTGCAAATCCCGCAGTATTTTCTTCTCACCTGTGGCGAAGTGGTCTTCTCTGTC
ACGGGATTGGAATTCTCATATTCTCAGGCTCCTTCCAACATGAAGTCGGTGCTTCAGGCA
GGATGGCTGCTGACCGTGGCTGTTGGCAACATCATTGTGCTCATCGTGGCAGGGGCAGGC
CAGTTCAGCAAACAGTGGGCCGAGTACATTCTATTTGCCGCGTTGCTTCTGGTCGTCTGT
GTAATTTTTGCCATCATGGCTCGGTTCTATACTTACATCAACCCAGCGGAGATCGAAGCT
CAATTTGATGAGGATGAAAAGAAAAACAGACTGGAAAAGAGTAACCCATATTTCATGTCA
GGGGCCAATTCACAGAAACAGATGTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
U13173

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:13

# Macromolecular_Interacting_Partner_3_Locus:
13q33-q34

# Macromolecular_Interacting_Partner_3_SNPs:
rs2297322; rs4646227; rs8187820; rs8187838; rs2274828; rs2274827; rs8187821; rs8187830; rs1339067; rs8187840; rs8187832; rs8187836; rs8187823; rs1289389; rs4646234; rs7331216; rs4646206; rs9554495; rs3783002; rs1768043; rs950906; rs950905; rs2297319; rs2802390; rs1331251; rs1289393; rs883962; rs8187826; rs6491441; rs9300504; rs2185207; rs3825428; rs11069326; rs6491438; rs1289394; rs4772122; rs4608199; rs4646215; rs4646221; rs9557034; rs1289390; rs7318138; rs4772124; rs10492578; rs7992817; rs9557033; rs914300; rs7326286; rs4646214; rs8001466; rs4772126; rs9517416; rs1289392; rs9584911; rs9513475; rs12853199; rs11618107; rs9513470; rs3782997; rs4772132; rs2263235; rs6491446; rs1768042; rs9584906; rs4771316; rs2066079; rs4646217; rs2297318; rs3782996; rs2390092; rs9513474; rs9300505; rs6491440; rs4772130; rs4772129; rs4646216; rs2390106; rs6491445; rs4646209; rs7997477; rs7998137; rs4772131; rs7983644; rs6491448; rs7338228; rs9584919; rs4646212; rs3782999; rs6491447; rs4646222; rs3783001; rs9584921; rs2297320; rs9517424; rs7324010; rs6491442; rs3782994; rs9554498; rs4350452; rs7990232; rs9513478; rs2297321; rs7339292; rs1576644; rs10454525; rs12427740; rs9517413; rs4646213; rs3783000; rs11069325; rs3782993; rs12853441; rs7331065; rs7995801; rs9584925; rs7335599; rs9783535; rs16955752; rs9582259; rs2802392; rs8000767; rs4646223; rs914301; rs12867528; rs9517428; rs4771315; rs11618901; rs9517414; rs9517417; rs9517419; rs6491449; rs12100089; rs7325784; rs1892503; rs7335430; rs9557036; rs9517406; rs4646224; rs9582260; rs7336318; rs7335961; rs7984336; rs4772128; rs9513477; rs7983080; rs6491443; rs1756988; rs9554496; rs7983051; rs7327300; rs9517423; rs1782672; rs8002712; rs4646208; rs7994445; rs9300508; rs6491444; rs2149494; rs9584922; rs12586112; rs16955725; rs1289391; rs8187837; rs12853368; rs4646207; rs9584916; rs9300509; rs1934064; rs6491437; rs6491450; rs16955728; rs9517409; rs3825429; rs4366582; rs7986109; rs4646235; rs7981545; rs1782674; rs3737087; rs35329772; rs1126836; rs11354027; rs9513468; rs35432591; rs9584926; rs809536; rs35418914; rs34315299; rs12876638; rs34823897; rs9584908; rs4644732; rs12866917; rs11409104; rs9584903; rs9554497; rs7321176; rs1782673; rs3831216; rs946402; rs9557037; rs12866940; rs4646220; rs34508410; rs7334595; rs9584915; rs7989936; rs34165009; rs34520897; rs9783588; rs4646210; rs8002282; rs34503390; rs12428457; rs2017894; rs12020036; rs9584909; rs11433753; rs17701332; rs1756989; rs11347963; rs5806073; rs12855763; rs35205657; rs9582257; rs35484191; rs34373331; rs9582258; rs12855410; rs9584914; rs9584924; rs2149495; rs7489959; rs4646230; rs11838832; rs35539223; rs9584907; rs946401; rs35520800; rs11309992; rs7990839; rs812231; rs11842116; rs9517420; rs35799720; rs11390654; rs7333570; rs4646218; rs35424966; rs9645892; rs3782995; rs12868220; rs12877013; rs11378347; rs9513467; rs9557035; rs9584904; rs12870597; rs9517418; rs9517421; rs34760702; rs9584913; rs28504043; rs6145194; rs17575153; rs35159274; rs4646231; rs3837539; rs33982897; rs4646219; rs1625299; rs4646228; rs9517405; rs1768044; rs10454524; rs35038911; rs10684111; rs12184574; rs34078820; rs34679094; rs35949883; rs7985400; rs9584902; rs34518098; rs1756990; rs9517430; rs4772127; rs35314410; rs4001067; rs35217525; rs12867080; rs9584905; rs35414294; rs9584912; rs33989824; rs7982748; rs9517412; rs9513476; rs7985707; rs4646226; rs9517411; rs9513471; rs4646232; rs7335161; rs12867104; rs2802391; rs7981646; rs13378672; rs4646211; rs7328065; rs34440379; rs36004561; rs35857425; rs932950; rs9557038; rs4646229; rs12871129; rs34922002; rs35251576; rs35455856; rs34803894; rs28514895; rs34078760; rs9584928; rs7993908; rs28672752; rs28573788; rs35039740; rs34298145; rs9517431; rs11405904; rs10851093; rs11840154; rs12863327; rs1614209; rs1626391; rs1629183; rs16955723; rs17655581; rs1768047; rs1782671; rs2066080; rs2251861; rs2252341; rs2390105; rs2802388; rs2802389; rs34170268; rs7317249; rs7320943; rs7326447; rs7329621; rs8187812; rs8187816; rs8187817; rs8187818; rs8187819; rs8187825; rs8187829; rs8187833; rs8187834; rs8187835; rs8187841; rs955052; rs955053; rs9554493; rs9557030; rs9557031; rs9557032; rs9557043; rs9557045; rs956839; rs9584900

# Macromolecular_Interacting_Partner_3_General_References:
7896779

# Macromolecular_Interacting_Partner_3_References:
15630234

# Macromolecular_Interacting_Partner_4_ID:
8209

# Macromolecular_Interacting_Partner_4_Name:
Runt-related transcription factor 2

# Macromolecular_Interacting_Partner_4_Synonyms:
Core-binding factor, alpha 1 subunit; CBF-alpha 1; Acute myeloid leukemia 3 protein; Oncogene AML-3; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEBP2-alpha A; PEA2-alpha A; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit; Osteoblast- specific transcription factor 2; OSF-2

# Macromolecular_Interacting_Partner_4_Gene_Name:
RUNX2

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Runtrelated transcription factor 2
MASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQ
QQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPN
FLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVA
RFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPS
LFSDRLSDLGRIPHPSMRVGVPPQNPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYD
QSYPSYLSQMTSPSIHSTTPLSSTRGTGLPAITDVPRRISDDDTATSDFCLWPSTLSKKS
QAGASELGPFSDPRQFPSISSLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHT
YLPPPYPGSSQSQSGPFQTSSTPYLYYGTSSGSYQFPMVPGGDRSPSRMLPPCTTTSNGS
TLLNPNLPNQNDGVDADGSHSSSPTVLNSSGRMDESVWRPY

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
521

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
56648

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
9.05

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  transcription factor activity
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'- PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits MYST4-dependent transcriptional activation

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00853:Runt;
PF08504:RunxI

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
RUNX2_HUMAN (Q13950)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
RUNX2

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
RUNX2

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:10472

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
AF001450

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_4_Locus:
6p21

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
9182765; 9434946; 14574404; 9651525; 9233771; 12145306; 9207800; 10521292; 10545612; 10689183; 10980549

# Macromolecular_Interacting_Partner_4_References:
15102049

# Macromolecular_Interacting_Partner_5_ID:
8202

# Macromolecular_Interacting_Partner_5_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_5_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_5_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_5_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_5_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_5_Locus:
10q22

# Macromolecular_Interacting_Partner_5_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_5_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_5_References:
16046297; 3095942

# Macromolecular_Interacting_Partner_6_ID:
8424

# Macromolecular_Interacting_Partner_6_Name:
Oligopeptide transporter, kidney isoform

# Macromolecular_Interacting_Partner_6_Synonyms:
Peptide transporter 2; Kidney H(+/peptide cotransporter; Solute carrier family 15 member 2

# Macromolecular_Interacting_Partner_6_Gene_Name:
SLC15A2

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Oligopeptide transporter, kidney isoform
MNPFQKNESKETLFSPVSIEEVPPRPPSPPKKPSPTICGSNYPLSIAFIVVNEFCERFSY
YGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLV
YVLGHVIKSLGALPILGGQVVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEER
TRYFSVFYLSINAGSLISTFITPMLRGDVQCFGEDCYALAFGVPGLLMVIALVVFAMGSK
IYNKPPPEGNIVAQVFKCIWFAISNRFKNRSGDIPKRHDWLDWAAEKYPKQLIMDVKALT
RVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPLLVLIFIPLFD
FVIYRLVSKCGINFSSLRKMAVGMILACLAFAVAARVEIKINEMAPAQPGPQEVFLQVLN
LADDEVKVTVVGNENNSLLIESIKSFQKTPHYSKLHLKTKSQDFHFHLKYHNLSLYTEHS
VQEKNWYSLVIREDGNSISSMMVKDTESRTTNGMTTVRFVNTLHKDVNISLSTDTSLNVG
EDYGVSAYRTVQRGEYPAVHCRTEDKNFSLNLGLLDFGAAYLFVITNNTNQGLQAWKIED
IPANKMSIRWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNIIV
LVVAQFSGLVQWAEFILFSCLLLVICLIFSIMGYYYVPVKTEDMRGPADKHIPHIQGNMI
KLETKKTKL

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
729

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
81942

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
8.38

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  transporter activity
Function:  peptide transporter activity
Function:  oligopeptide transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  peptide transport
Process:  oligopeptide transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_6_Specific_Function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00854:PTR2

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
58-78
88-108
115-135
140-160
184-204
218-238
296-316
344-364
381-401
568-588
612-632
644-664
675-695

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
999213

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
S15A2_HUMAN (Q16348)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SLC15A2

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SLC15A2

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:10921

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>2190 bp
ATGAATCCTTTCCAGAAAAATGAGTCCAAGGAAACTCTTTTTTCACCTGTCTCCATTGAA
GAGGTACCACCTCGACCACCTAGCCCTCCAAAGAAGCCATCTCCGACAATCTGTGGCTCC
AACTATCCACTGAGCATTGCCTTCATTGTGGTGAATGAATTCTGCGAGCGCTTTTCCTAT
TATGGAATGAAAGCTGTGCTGATCCTGTATTTCCTGTATTTCCTGCACTGGAATGAAGAT
ACCTCCACATCTATATACCATGCCTTCAGCAGCCTCTGTTATTTTACTCCCATCCTGGGA
GCAGCCATTGCTGACTCGTGGTTGGGAAAATTCAAGACAATCATCTATCTCTCCTTGGTG
TATGTGCTTGGCCATGTGATCAAGTCCTTGGGTGCCTTACCAATACTGGGAGGACAAGTG
GTACACACAGTCCTATCATTGATCGGCCTGAGTCTAATAGCTTTGGGGACAGGAGGCATC
AAACCCTGTGTGGCAGCTTTTGGTGGAGACCAGTTTGAAGAAAAACATGCAGAGGAACGG
ACTAGATACTTCTCAGTCTTCTACCTGTCCATCAATGCAGGGAGCTTGATTTCTACATTT
ATCACACCCATGCTGAGAGGAGATGTGCAATGTTTTGGAGAAGACTGCTATGCATTGGCT
TTTGGAGTTCCAGGACTGCTCATGGTAATTGCACTTGTTGTGTTTGCAATGGGAAGCAAA
ATATACAATAAACCACCCCCTGAAGGAAACATAGTGGCTCAAGTTTTCAAATGTATCTGG
TTTGCTATTTCCAATCGTTTCAAGAACCGTTCTGGAGACATTCCAAAGCGACACGACTGG
CTAGACTGGGCGGCTGAGAAATATCCAAAGCAGCTCATTATGGATGTAAAGGCACTGACC
AGGGTACTATTCCTTTATATCCCATTGCCCATGTTCTGGGCTCTTTTGGATCAGCAGGGT
TCACGATGGACTTTGCAAGCCATCAGGATGAATAGGAATTTGGGGTTTTTTGTGCTTCAG
CCGGACCAGATGCAGGTTCTAAATCCCCTTCTGGTTCTTATCTTCATCCCGTTGTTTGAC
TTTGTCATTTATCGTCTGGTCTCCAAGTGTGGAATTAACTTCTCATCACTTAGGAAAATG
GCTGTTGGTATGATCCTAGCATGCCTGGCATTTGCAGTTGCGGCACGTGTAGAGATAAAA
ATAAATGAAATGGCCCCAGCCCAGCCAGGTCCCCAGGAGGTTTTCCTACAAGTCTTGAAT
CTGGCAGATGATGAGGTGAAGGTGACAGTGGTGGGAAATGAAAACAATTCTCTGTTGATA
GAGTCCATCAAATCCTTTCAGAAAACACCACACTATTCCAAACTGCACCTGAAAACAAAA
AGCCAGGATTTTCACTTCCACCTGAAATATCACAATTTGTCTCTCTACACTGAGCATTCT
GTGCAGGAGAAGAACTGGTACAGTCTTGTCATTCGTGAAGATGGGAACAGTATCTCCAGC
ATGATGGTAAAGGATACAGAAAGCAGAACAACCAATGGGATGACAACCGTGAGGTTTGTT
AACACTTTGCATAAAGATGTCAACATCTCCCTGAGTACAGATACCTCTCTCAATGTTGGT
GAAGACTATGGTGTGTCTGCTTATAGAACTGTGCAAAGAGGAGAATACCCTGCAGTGCAC
TGTAGAACAGAAGATAAGAACTTTTCTCTGAATTTGGGTCTTCTAGACTTTGGTGCAGCA
TATCTGTTTGTTATTACTAATAACACCAATCAGGGTCTTCAGGCCTGGAAGATTGAAGAC
ATTCCAGCCAACAAAATGTCCATTCGGTGGCAGCTACCACAATATGCCCTGGTTACAGCT
GGGGAGGTCATGTTCTCTGTCACAGGTCTTGAGTTTTCTTATTCTCAGGCTCCCTCTAGC
ATGAAATCTGTGCTCCAGGCAGCTTGGCTATTGACAATTGCAGTTGGGAATATCATCGTG
CTTGTTGTGGCACAGTTCAGTGGCCTGGTACAGTGGGCCGAATTCATTTTGTTTTCCTGC
CTCCTGCTGGTGATCTGCCTGATCTTCTCCATCATGGGCTACTACTATGTTCCTGTAAAG
ACAGAGGATATGCGGGGTCCAGCAGATAAGCACATTCCTCACATCCAGGGGAACATGATC
AAACTAGAGACCAAGAAGACAAAACTCTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
S78203

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_6_Locus:
3q13.33

# Macromolecular_Interacting_Partner_6_SNPs:
rs1143672; rs2257212; rs1143671; rs1143668; rs1143667; rs1920314; rs1143673; rs2293616; rs1143670; rs1143669; rs1920313; rs2689273; rs2049331; rs1357531; rs866928; rs2877568; rs874741; rs866929; rs1523519; rs2049330; rs2332054; rs2141615; rs1881998; rs11914993; rs2293615; rs953730; rs3805134; rs874742; rs4305455; rs9812515; rs2332055; rs9289182; rs9830721; rs3817601; rs11920521; rs2293612; rs9862977; rs3762822; rs6803757; rs2257214; rs2689283; rs1882000; rs3805132; rs2877566; rs866927; rs2689284; rs2257132; rs3805138; rs1881997; rs9289183; rs2293614; rs866926; rs1316397; rs1920302; rs1316301; rs2257119; rs9849724; rs2250067; rs1882002; rs9842387; rs6780234; rs2689288; rs3762819; rs7635449; rs2700424; rs1881999; rs4583698; rs3762821; rs2332052; rs1920303; rs2332046; rs2332044; rs2689282; rs9816071; rs2877569; rs6438687; rs2689272; rs2689291; rs9836339; rs2700421; rs7645647; rs9815649; rs4465981; rs9863155; rs9815756; rs1881995; rs2332053; rs6770115; rs2178415; rs9289181; rs2250065; rs9816215; rs2332050; rs6794360; rs2700426; rs2700420; rs7623754; rs2257120; rs2257123; rs2293613; rs2257109; rs2332051; rs9866936; rs2700425; rs9868185; rs9850685; rs9870245; rs4118376; rs9822474; rs9843053; rs1920315; rs3932367; rs2257115; rs2257124; rs2700423; rs11920547; rs9871534; rs9845790; rs1920319; rs2689292; rs7637569; rs9835875; rs3817599; rs3792596; rs6799626; rs11918861; rs12330644; rs9713652; rs2951471; rs6791876; rs9827390; rs9810707; rs7619800; rs9829070; rs12496036; rs9837144; rs3792597; rs9713657; rs9713895; rs2262494; rs2293611; rs1920317; rs11707541; rs9827473; rs11924085; rs9713900; rs2689277; rs6414289; rs9831607; rs10934562; rs2293608; rs9811473; rs6775183; rs9714033; rs9714238; rs9714239; rs11922812; rs2332049; rs1881996; rs2877567; rs1882004; rs2700416; rs6765799; rs9831723; rs9844954; rs2689281; rs9828753; rs1344279; rs2332043; rs17203299; rs1882003; rs4285028; rs4603998; rs11720061; rs11720058; rs10470412; rs12498028; rs17854312; rs1920305; rs4388019; rs41271413; rs2332045; rs34567530; rs35119143; rs7652204; rs2332047; rs28790275; rs41271421; rs36202666; rs4432693; rs11425666; rs41271419; rs3215371; rs35902163; rs3926094; rs1920304; rs10703708; rs12489233; rs13068438; rs11371908; rs34226020; rs34273335; rs28481518; rs36038750; rs1920301; rs12629742; rs36019076; rs13319084; rs35492489; rs2689289; rs3805136; rs13093033; rs1920300; rs35943712; rs7428886; rs6780559; rs35032381; rs7629964; rs5852283; rs28861465; rs2293610; rs3215370; rs36045594; rs34837785; rs34909578; rs13064029; rs41271415; rs13317021; rs34611077; rs1920318; rs6790936; rs28529298; rs35406725; rs3840261; rs28844001; rs28871629; rs4250029; rs3047583; rs13086454; rs11425667; rs28789687; rs36159816; rs41271417; rs36177447; rs2332048; rs35879145; rs34900621; rs13077082; rs34542794; rs3762820; rs35694140; rs28390159; rs34354261; rs2689287; rs28823352; rs9828757; rs35577523; rs35480514; rs2091666; rs34227248; rs9877671; rs10470411; rs1136995; rs11924158; rs1343979; rs13860; rs1920307; rs1920308; rs1920309; rs1920310; rs1920311; rs1920312; rs2689275; rs35446226; rs35538837; rs4422354; rs6438689; rs6790281; rs7615571; rs7650341; rs9289180; rs9790267; rs9822660; rs9829181; rs9867460; rs9871743

# Macromolecular_Interacting_Partner_6_General_References:
7756356

# Macromolecular_Interacting_Partner_6_References:
11474785; 15056281; 17034769

# Macromolecular_Interacting_Partner_7_ID:
7913

# Macromolecular_Interacting_Partner_7_Name:
Heat shock 70 kDa protein 1

# Macromolecular_Interacting_Partner_7_Synonyms:
HSP70.1; HSP70-1/HSP70-2

# Macromolecular_Interacting_Partner_7_Gene_Name:
HSPA1A

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Heat shock 70 kDa protein 1
MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVA
LNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEIS
SMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAA
IAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNH
FVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRA
RFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLN
KSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTI
PTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDI
DANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKN
ALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELE
QVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
641

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
70053

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
5.31

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Macromolecular_Interacting_Partner_7_Specific_Function:
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00012:HSP70

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
188488

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
HSP71_HUMAN (P08107)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
HSPA1A

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
HSPA1A

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:5232

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1926 bp
ATGGCCAAAGCCGCGGCGATCGGCATCGACCTGGGCACCACCTACTCCTGCGTGGGGGTG
TTCCAACACGGCAAGGTGGAGATCATCGCCAACGACCAGGGCAACCGCACCACCCCCAGC
TACGTGGCCTTCACGGACACCGAGCGGCTCATCGGGGATGCGGCCAAGAACCAGGTGGCG
CTGAACCCGCAGAACACCGTGTTTGACGCGAAGCGCCTGATTGGCCGCAAGTTCGGCGAC
CCGGTGGTGCAGTCGGACATGAAGCACTGGCCTTTCCAGGTGATCAACGACGGAGACAAG
CCCAAGGTGCAGGTGAGCTACAAGGGGGAGACCAAGGCATTCTACCCCGAGGAGATCTCG
TCCATGGTGCTGACCAAGATGAAGGAGATCGCCGAGGCGTACCTGGGCTACCCGGTGACC
AACGCGGTGATCACCGTGCCGGCCTACTTCAACGACTCGCAGCGCCAGGCCACCAAGGAT
GCGGGTGTGATCGCGGGGCTCAACGTGCTGCGGATCATCAACGAGCCCACGGCCGCCGCC
ATCGCCTACGGCCTGGACAGAACGGGCAAGGGGGAGCGCAACGTGCTCATCTTTGACCTG
GGCGGGGGCACCTTCGACGTGTCCATCCTGACGATCGACGACGGCATCTTCGAGGTGAAG
GCCACGGCCGGGGACACCCACCTGGGTGGGGAGGACTTTGACAACAGGCTGGTGAACCAC
TTCGTGGAGGAGTTCAAGAGAAAACACAAGAAGGACATCAGCCAGAACAAGCGAGCCGTG
AGGCGGCTGCGCACCGCCTGCGAGAGGGCCAAGAGGACCCTGTCGTCCAGCACCCAGGCC
AGCCTGGAGATCGACTCCCTGTTTGAGGGCATCGACTTCTACACGTCCATCACCAGGGCG
AGGTTCGAGGAGCTGTGCTCCGACCTGTTCCGAAGCACCCTGGAGCCCGTGGAGAAGGCT
CTGCGCGACGCCAAGCTGGACAAGGCCCAGATTCACGACCTGGTCCTGGTCGGGGGCTCC
ACCCGCATCCCCAAGGTGCAGAAGCTGCTGCAGGACTTCTTCAACGGGCGCGACCTGAAC
AAGAGCATCAACCCCGACGAGGCTGTGGCCTACGGGGCGGCGGTGCAGGCGGCCATCCTG
ATGGGGGACAAGTCCGAGAACGTGCAGGACCTGCTGCTGCTGGACGTGGCTCCCCTGTCG
CTGGGGCTGGAGACGGCCGGAGGCGTGATGACTGCCCTGATCAAGCGCAACTCCACCATC
CCCACCAAGCAGACGCAGATCTTCACCACCTACTCCGACAACCAACCCGGGGTGCTGATC
CAGGTGTACGAGGGCGAGAGGGCCATGACGAAAGACAACAATCTGTTGGGGCGCTTCGAG
CTGAGCGGCATCCCTCCGGCCCCCAGGGGCGTGCCCCAGATCGAGGTGACCTTCGACATC
GATGCCAACGGCATCCTGAACGTCACGGCCACGGACAAGAGCACCGGCAAGGCCAACAAG
ATCACCATCACCAACGACAAGGGCCGCCTGAGCAAGGAGGAGATCGAGCGCATGGTGCAG
GAGGCGGAGAAGTACAAAGCGGAGGACGAGGTGCAGCGCGAGAGGGTGTCAGCCAAGAAC
GCCCTGGAGTCCTACGCCTTCAACATGAAGAGCGCCGTGGAGGATGAGGGGCTCAAGGGC
AAGATCAGCGAGGCCGACAAGAAGAAGGTGCTGGACAAGTGTCAAGAGGTCATCTCGTGG
CTGGACGCCAACACCTTGGCCGAGAAGGACGAGTTTGAGCACAAGAGGAAGGAGCTGGAG
CAGGTGTGTAACCCCATCATCAGCGGACTGTACCAGGGTGCCGGTGGTCCCGGGCCTGGG
GGCTTCGGGGCTCAGGGTCCCAAGGGAGGGTCTGGGTCAGGCCCCACCATTGAGGAGGTA
GATTAG

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
M59828

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_7_Locus:
6p21.3

# Macromolecular_Interacting_Partner_7_SNPs:
Not Available

# Macromolecular_Interacting_Partner_7_General_References:
1700760; 3931075; 14574404; 2538825; 3786141; 10216320

# Macromolecular_Interacting_Partner_7_References:
12498304; 16945336; 16949620; 16984587

End of HMDB00033

Beginning of HMDB00034
# Accession_No:
HMDB00034

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-22 17:00:42

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Adenine

# Description:
Adenine is a purine base. Adenine is found in both DNA and RNA. Adenine is a fundamental component of adenine nucleotides. Adenine forms adenosine, a nucleoside, when attached to ribose, and deoxyadenosine when attached to deoxyribose; it forms adenosine triphosphate (ATP), a nucleotide, when three phosphate groups are added to adenosine. Adenosine triphosphate is used in cellular metabolism as one of the basic methods of transferring chemical energy between chemical reactions.
Purine inborn errors of metabolism (IEM) are serious hereditary disorders, which should be suspected in any case of neonatal fitting, failure to thrive, recurrent infections, neurological deficit, renal disease, self-mutilation and other manifestations. Investigation usually starts with uric acid (UA) determination in urine and plasma. (OMIM 300322, 229600, 603027, 232400, 232600, 232800, 201450, 220150, 232200, 162000, 164050, 278300). (PMID: 17052198, 17520339)

# Synonyms:
1,6-Dihydro-6-iminopurine; 1H-Purin-6-amine; 1H-Purine-6-amine; 3,6-Dihydro-6-iminopurine; 6-Amino-1H-purine; 6-Amino-3H-purine; 6-Amino-7H-purine; 6-Amino-9H-purine; 6-Aminopurine; 6-amino-Purine; 9H-Purin-6-amine; 9H-Purin-6-yl-amin; 9H-Purine-6-amine; 9H-purin-6-ylamine; Ade; Adenin; Adenine; Adeninimine; Vitamin B4

# Chemical_IUPAC_Name:
7H-purin-6-amine

# Chemical_Formula:
C5H5N5

# Chemical_Structure:
tbl_chemical:::HMDB00034_ZOOM.png:::119283144823038917

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00034_THUMB.png:::11928314464392350

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aromatic amine; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
DNA component; Component of Purine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
135.05449

# Molecular_Weight_Avg:
135.12671

# Smiles_String_isomeric:
NC1=NC=NC2=C1NC=N2

# Smiles_String_canonical:
NC1=NC=NC2=C1NC=N2

# KEGG_Compound_ID:
C00147

# BioCyc_ID:
ADENINE

# PubChem_CID:
190

# PubChem_SID:
8144939; 11405393; 828509; 11377286; 10322142; 832226; 7987265; 11361989; 589178; 836808; 149245; 11487391; 823652; 7885703; 826914; 11370094; 585680; 610762; 11484162; 826232; 11369124; 7847102; 11109934; 854817; 11493705; 822670; 823493; 828511; 10408453; 7853710; 11494920; 11371752; 826855; 841461; 11488399; 11373133; 827713; 830718; 834956; 823885; 584702; 830750; 823157; 5385494; 11367532; 819247; 830693; 11375694; 834959; 11341806; 3135000; 820745; 854374; 822025; 11490432; 12016036; 11375582; 3447; 11537598; 7885710; 826016; 11378265; 10317179; 11364970; 8025303; 825133; 5344002; 10534154; 7885885; 11366562; 11364000; 855041; 8150497; 2101; 830741; 2102; 825880; 830162

# OMIM_ID:
102600; 103220

# Metagene_ID:
ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT): 406

# BiGG_ID:
34039

# Wikipedia_ID:
Adenine

# METLIN_ID:
85

# Ref_ID:
12951489; 15063338; 15994977; 16055624; 17126311; 15715490; 401462; 16613999; 6656991; 12829005; 11985597

# ChEBI_ID:
16708

# CAS_Registry_Number:
73-24-5

# InChI:
InChI=1/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)

# Synthesis_Reference:
Journal of the Chemical Society  (1943),     386-7.

# Melting_Point:
360 oC

# Melting_Point_predicted:
116.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1.03 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
11.5 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-0.09 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-0.24 [Predicted by ALOGPS]; -0.3 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Adenine.htm:::1132562191927978699

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Adenine.mol:::1132723802593374589

# SDF_File_[Text]:
tbl_chemical:::HMDB00034.sdf:::119283144312182809

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00034.pdb:::119283144469572592

# PDB_ID:
1AHA

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1AHA.txt:::113272089925084109

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041008_P00_02_HW_1DP_PRESAT_expanded_2.gif:::114168246164641225

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041008_P00_02_HW_1DP_presat.zip:::1175124391570355147

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041008_P00_02_HW_1DP_Assigned.png:::11465975787836228

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::73_24_5p_presat_JM.GIF:::1132883818453983363

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041008_P00_02_HW_1DP_presat.zip:::115203982965426049

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041008_P00_02_HW_2DHSQC_794.png:::114805794258284634

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041008_P00_02_HW_2DHSQC_794.zip:::114805794258629976

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041008_P00_02_HW_2DHSQC_794_Assigned.png:::115023651715193146

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Adenine.gif:::1132732101000585129

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00034_peaks.txt:::1156309500777524545

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Adenine_C.gif:::1132737663175405845

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00034_peaks.txt:::1156310692490605820

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00034L.png:::117555261869239412; Medium Energy:tbl_ms:::HMDB00034M.png:::11755526700088852; High Energy:tbl_ms:::HMDB00034H.png:::117555270868050927

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000060.png:::116890825170340102

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000060.txt:::116890825204663179

# Cellular_Location:
Cytoplasm; Nucleus; Extracellular; lysosome

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Blood	0.300 (0.200-0.400)	umol/L	Adult:>18_yrs_old	Both	Normal	6656991
Blood	 0.64 +/- 0.15	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	0 - 0.2	uM	Adult:>18_yrs_old	Both	Normal	6656991


# Concentration_[Abnormal]:
Urine	7.11	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Adenine Phosphoribosyltransferase (APRT) Deficiency	17126311
Blood	3.57	uM	Adult:>18_yrs_old	Both	Adenine phosphoribosyltransferase (APRT) deficiency.	17126311
Cerebrospinal_Fluid(CSF)	0.5 (0 - 18.0)	uM	Children:1-13_yrs_old	N/A	Bacterial meningitis	12581805
Cerebrospinal_Fluid(CSF)	0.35 (0 - 23.4)	uM	Children:1-13_yrs_old	N/A	Tuberculous meningitis	12581805
Cerebrospinal_Fluid(CSF)	0.96 (0 - 12.0)	uM	Children:1-13_yrs_old	N/A	Viral meningitis	12581805


# Associated_Disorders:
Adenine Phosphoribosyltransferase (APRT) Deficiency; Adenine phosphoribosyltransferase (APRT) deficiency.; Bacterial meningitis; Friedreich's Ataxia; Heterotopia; Tuberculous meningitis; Viral meningitis

# Pathway_Names:
Purine metabolism;Nicotinate and nicotinamide metabolism

# Pathway_Images:
Purine_Synthesis.jpg;Nicotinamide_synthesis_(NADH).jpg

# KEGG_Images:
map00230;map00760

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;Nicotinamide_synthesis_(NADH)_Graph.jpg

# Pathway_SBMLs:
Purine_Synthesis.xml;Nicotinamide_synthesis_(NADH).xml

# Metabolic_Enzyme_1_ID:
5806

# Metabolic_Enzyme_1_Name:
Thymidine phosphorylase precursor

# Metabolic_Enzyme_1_Synonyms:
TdRPase; TP; Platelet-derived endothelial cell growth factor; PD-ECGF; Gliostatin

# Metabolic_Enzyme_1_Gene_Name:
ECGF1

# Metabolic_Enzyme_1_Protein_Sequence:
>Thymidine phosphorylase precursor
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ

# Metabolic_Enzyme_1_Number_of_Residues:
482

# Metabolic_Enzyme_1_Molecular_Weight:
49956

# Metabolic_Enzyme_1_Theoretical_pI:
5.19

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  pyrimidine base metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis

# Metabolic_Enzyme_1_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_1_Reaction:
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF02885:Glycos_trans_3N;
PF00591:Glycos_transf_3;
PF07831:PYNP_C

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.2.4

# Metabolic_Enzyme_1_GenBank_ID_Protein:
189701

# Metabolic_Enzyme_1_SwissProt_ID:
TYPH_HUMAN (P19971)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ECGF1

# Metabolic_Enzyme_1_Geneatlas_id:
ECGF1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:3148

# Metabolic_Enzyme_1_PDB_ID:
1UOU

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1449 bp
ATGGCAGCCTTGATGACCCCGGGAACCGGGGCCCCACCCGCGCCTGGTGACTTCTCCGGG
GAAGGGAGCCAGGGACTTCCCGACCCTTCGCCAGAGCCCAAGCAGCTCCCGGAGCTGATC
CGCATGAAGCGAGACGGAGGCCGCCTGAGCGAAGCGGACATCAGGGGCTTCGTGGCCGCT
GTGGTGAATGGGAGCGCGCAGGGCGCACAGATCGGGGCCATGCTGATGGCCATCCGACTT
CGGGGCATGGATCTGGAGGAGACCTCGGTGCTGACCCAGGCCCTGGCTCAGTCGGGACAG
CAGCTGGAGTGGCCAGAGGCCTGGCGCCAGCAGCTTGTGGACAAGCATTCCACAGGGGGT
GTGGGTGACAAGGTCAGCCTGGTCCTCGCACCTGCCCTGGCGGCATGTGGCTGCAAGGTG
CCAATGATCAGCGGACGTGGTCTGGGGCACACAGGAGGCACCTTGGATAAGCTGGAGTCT
ATTCCTGGATTCAATGTCATCCAGAGCCCAGAGCAGATGCAAGTGCTGCTGGACCAGGCG
GGCTGCTGTATCGTGGGTCAGAGTGAGCAGCTGGTTCCTGCGGACGGAATCCTATATGCA
GCCAGAGATGTGACAGCCACCGTGGACAGCCTGCCACTCATCACAGCCTCCATTCTCAGT
AAGAAACTCGTGGAGGGGCTGTCCGCTCTGGTGGTGGACGTTAAGTTCGGAGGGGCCGCC
GTCTTCCCCAACCAGGAGCAGGCCCGGGAGCTGGCAAAGACGCTGGTTGGCGTGGGAGCC
AGCCTAGGGCTTCGGGTCGCGGCAGCGCTGACCGCCATGGACAAGCCCCTGGGTCGCTGC
GTGGGCCACGCCCTGGAGGTGGAGGAGGCGCTGCTCTGCATGGACGGCGCAGGCCCGCCA
GACTTAAGGGACCTGGTCACCACGCTCGGGGGCGCCCTGCTCTGGCTCAGCGGACACGCG
GGGACTCAGGCTCAGGGCGCTGCCCGGGTGGCCGCGGCGCTGGACGACGGCTCGGCCCTT
GGCCGCTTCGAGCGGATGCTGGCGGCGCAGGGCGTGGATCCCGGTCTGGCCCGAGCCCTG
TGCTCGGGAAGTCCCGCAGAACGCCGGCAGCTGCTGCCTCGCGCCCGGGAGCAGGAGGAG
CTGCTGGCGCCCGCAGATGGCACCGTGGAGCTGGTCCGGGCGCTGCCGCTGGCGCTGGTG
CTGCACGAGCTCGGGGCCGGGCGCAGCCGCGCTGGGGAGCCGCTCCGCCTGGGGGTGGGC
GCAGAGCTGCTGGTCGACGTGGGTCAGAGGCTGCGCCGTGGGACCCCCTGGCTCCGCGTG
CACCGGGACGGCCCCGCGCTCAGCGGCCCGCAGAGCCGCGCCCTGCAGGAGGCGCTCGTA
CTCTCCGACCGCGCGCCATTCGCCGCCCCCTCGCCCTTCGCAGAGCTCGTTCTGCCGCCG
CAGCAATAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M63193

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_1_Locus:
22q13|22q13.33

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
2467210; 1570012; 1400349; 1590793; 9924029; 12177387

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5634

# Metabolic_Enzyme_2_Name:
S-methyl-5-thioadenosine phosphorylase

# Metabolic_Enzyme_2_Synonyms:
5'- methylthioadenosine phosphorylase; MTA phosphorylase; MTAPase

# Metabolic_Enzyme_2_Gene_Name:
MTAP

# Metabolic_Enzyme_2_Protein_Sequence:
>Smethyl5thioadenosine phosphorylase
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLAR
HGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMR
PQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSR
AESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTL
KENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH

# Metabolic_Enzyme_2_Number_of_Residues:
283

# Metabolic_Enzyme_2_Molecular_Weight:
31236

# Metabolic_Enzyme_2_Theoretical_pI:
7.21

# Metabolic_Enzyme_2_GO_Classification:
Not Available

# Metabolic_Enzyme_2_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine

# Metabolic_Enzyme_2_Pathway:
Not Available

# Metabolic_Enzyme_2_Reaction:
S-methyl-5-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.4.2.28

# Metabolic_Enzyme_2_GenBank_ID_Protein:
847724

# Metabolic_Enzyme_2_SwissProt_ID:
MTAP_HUMAN (Q13126)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
MTAP

# Metabolic_Enzyme_2_Geneatlas_id:
MTAP

# Metabolic_Enzyme_2_hgnc_id:
HGNC:7413

# Metabolic_Enzyme_2_PDB_ID:
1SD2

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>852 bp
ATGGCCTCTGGCACCACCACCACCGCCGTGAAGATTGGAATAATTGGTGGAACAGGCCTG
GATGATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAG
CCATCTGATGCCTTAATTTTGGGGAAGATAAAAAATGTTGATTGCATCCTCCTTGCAAGG
CATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCT
TTGAAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAG
GAGATTCAGCCCGGCGATATTGTCATTATTGATCAGTTCATTGACAGGACCACTATGAGA
CCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATG
GCTGAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGA
CTCCGGTGCCACTCAAAGGGGACAATGGTCACAATCGAGGGACCTCGTTTTAGCTCCCGG
GCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCA
GAGGTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGAT
TATGACTGCTGGAAGGAGCACGAGGAAGCAGTTTCGGTGGACCGGGTCTTAAAGACCCTG
AAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCC
ACAGAATGGTCAGAAACCCTCCATAACCTGAAGAATATGGCCCAGTTTTCTGTTTTATTA
CCAAGACATTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
U22233

# Metabolic_Enzyme_2_Chromosome_Location:
Not Available

# Metabolic_Enzyme_2_Locus:
Not Available

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
7604019; 8650244; 8687427; 10404592

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5676

# Metabolic_Enzyme_3_Name:
Adenine phosphoribosyltransferase

# Metabolic_Enzyme_3_Synonyms:
APRT

# Metabolic_Enzyme_3_Gene_Name:
APRT

# Metabolic_Enzyme_3_Protein_Sequence:
>Adenine phosphoribosyltransferase
MADSELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDY
IAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTLWASYSLEYGKAELEIQKDALEPG
QRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSLKGREKLAPVPFFSLLQYE


# Metabolic_Enzyme_3_Number_of_Residues:
180

# Metabolic_Enzyme_3_Molecular_Weight:
19608

# Metabolic_Enzyme_3_Theoretical_pI:
5.82

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
Function:  adenine phosphoribosyltransferase activity
 ||
>>>
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  purine base metabolism
Process:  purine base salvage
Process:  adenine salvage
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_3_Reaction:
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00156:Pribosyltran

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.4.2.7

# Metabolic_Enzyme_3_GenBank_ID_Protein:
28819

# Metabolic_Enzyme_3_SwissProt_ID:
APT_HUMAN (P07741)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
APRT

# Metabolic_Enzyme_3_Geneatlas_id:
APRT

# Metabolic_Enzyme_3_hgnc_id:
HGNC:626

# Metabolic_Enzyme_3_PDB_ID:
1ORE

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>543 bp
ATGGCCGACTCCGAGCTGCAGCTGGTTGAGCAGCGGATCCGCAGCTTCCCCGACTTCCCC
ACCCCAGGCGTGGTATTCAGGGACATCTCGCCCGTCCTGAAGGACCCCGCCTCCTTCCGC
GCCGCCATCGGCCTCCTGGCGCGACACCTGAAGGCGACCCACGGGGGCCGCATCGACTAC
ATCGCAGGCCTAGACTCCCGAGGCTTCCTCTTTGGCCCCTCCCTGGCCCAGGAGCTTGGA
CTGGGCTGCGTGCTCATCCGAAAGCGGGGGAAGCTGCCAGGCCCCACTCTGTGGGCCTCC
TATTCCCTGGAGTACGGGAAGGCTGAGCTGGAGATTCAGAAAGACGCCCTGGAGCCAGGA
CAGAGGGTGGTCGTCGTGGATGATCTGCTGGCCACTGGTGGAACCATGAACGCTGCCTGT
GAGCTGCTGGGCCGCCTGCAGGCTGAGGTCCTGGAGTGCGTGAGCCTGGTGGAGCTGACC
TCGCTTAAGGGCAGGGAGAAGCTGGCACCTGTACCCTTCTTCTCTCTCCTGCAGTATGAG
TGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
Y00486

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_3_Locus:
16q24

# Metabolic_Enzyme_3_SNPs:
rs8191472; rs8191473; rs2242172; rs8191478; rs8191483; rs3214057; rs8191477; rs8191489; rs8191488; rs8191480; rs8191492; rs2242173; rs8191470; rs8191487; rs8191484; rs8191493; rs8191475; rs8191471; rs537641; rs3826075; rs564235; rs535070; rs8191463; rs3759950; rs541276; rs3759952; rs3759951; rs8191468; rs8191460; rs8191465; rs3826074; rs8191464; rs8191469; rs8191466; rs8191461; rs8191458; rs8191494; rs28999113; rs35148077; rs35095508; rs3169258; rs2911456; rs34926513; rs8191476; rs8191491; rs8191482; rs8191495; rs8191486; rs8191481; rs8191479; rs8191474; rs8191485; rs8191490; rs8191457; rs35132384; rs8191459; rs12929472; rs28712013; rs12929307; rs8191467; rs11076715; rs11076716; rs11076718; rs1141390; rs11640595; rs12932340; rs12935469; rs15829; rs1799825; rs1834065; rs2070256; rs2303271; rs2303272; rs2303273; rs3177509; rs3218720; rs3218721; rs3218722; rs3218723; rs3218724; rs3218725; rs3218726; rs3218727; rs3218728; rs3218729; rs3218730; rs3743548; rs3784890; rs3826065; rs3826066; rs3826067; rs3826068; rs3826069; rs3826070; rs3826071; rs4356464; rs4503779; rs4695; rs475667; rs480727; rs507329; rs510862; rs550269; rs555812; rs559678; rs565211; rs572275; rs8059203; rs8191502; rs8191504; rs8191509

# Metabolic_Enzyme_3_General_References:
3684585; 3554238; 3531209; 12665801; 1746557; 7915931; 3680503; 3343350; 1353080; 11243733

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5805

# Metabolic_Enzyme_4_Name:
Purine nucleoside phosphorylase

# Metabolic_Enzyme_4_Synonyms:
Inosine phosphorylase; PNP

# Metabolic_Enzyme_4_Gene_Name:
NP

# Metabolic_Enzyme_4_Protein_Sequence:
>Purine nucleoside phosphorylase
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS

# Metabolic_Enzyme_4_Number_of_Residues:
289

# Metabolic_Enzyme_4_Molecular_Weight:
32118

# Metabolic_Enzyme_4_Theoretical_pI:
6.95

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  purine-nucleoside phosphorylase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_4_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_4_Reaction:
purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00896:Mtap_PNP

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.4.2.1

# Metabolic_Enzyme_4_GenBank_ID_Protein:
35565

# Metabolic_Enzyme_4_SwissProt_ID:
PNPH_HUMAN (P00491)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
NP

# Metabolic_Enzyme_4_Geneatlas_id:
NP

# Metabolic_Enzyme_4_hgnc_id:
HGNC:7892

# Metabolic_Enzyme_4_PDB_ID:
1RT9

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>870 bp
ATGGAGAACGGATACACCTATGAAGATTATAAGAACACTGCAGAATGGCTTCTGTCTCAT
ACTAAGCACCGACCTCAAGTTGCAATAATCTGTGGTTCTGGATTAGGAGGTCTGACTGAT
AAATTAACTCAGGCCCAGATCTTTGACTACAGTGAAATCCCCAACTTTCCTCGAAGTACA
GTGCCAGGTCATGCTGGCCGACTGGTGTTTGGGTTCCTGAATGGCAGGGCCTGTGTGATG
ATGCAGGGCAGGTTCCACATGTATGAAGGGTACCCACTCTGGAAGGTGACATTCCCAGTG
AGGGTTTTCCACCTTCTGGGTGTGGACACCCTGGTAGTCACCAATGCAGCAGGAGGGCTG
AACCCCAAGTTTGAGGTTGGAGATATCATGCTGATCCGTGACCATATCAACCTACCTGGT
TTCAGTGGTCAGAACCCTCTCAGAGGGCCCAATGATGAAAGGTTTGGAGATCGTTTCCCT
GCCATGTCTGATGCCTACGACCGGACTATGAGGCAGAGGGCTCTCAGTACCTGGAAACAA
ATGGGGGAGCAACGTGAGCTACAGGAAGGCACCTATGTGATGGTGGCAGGCCCCAGCTTT
GAGACTGTGGCAGAATGTCGTGTGCTGCAGAAGCTGGGAGCAGACGCTGTTGGCATGAGT
ACAGTACCAGAAGTTATCGTTGCACGGCACTGTGGACTTCGAGTCTTTGGCTTCTCACTC
ATCACTAACAAGGTCATCATGGATTATGAAAGCCTGGAGAAGGCCAACCATGAAGAAGTC
TTAGCAGCTGGCAAACAAGCTGCACAGAAATTGGAACAGTTTGTCTCCATTCTTATGGCC
AGCATTCCACTCCCTGACAAAGCCAGTTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
X00737

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_4_Locus:
14q13.1

# Metabolic_Enzyme_4_SNPs:
rs1049564; rs1130650; rs1049562; rs7785; rs1617940; rs1760940; rs1713420; rs1760935; rs1713422; rs1713421; rs3790064; rs3790065; rs1713429; rs17882804; rs17880405; rs1756369; rs12147688; rs8008133; rs17881431; rs17881345; rs7154909; rs17883821; rs17885781; rs1760934; rs17879107; rs17880844; rs17879913; rs17881184; rs17885714; rs17880480; rs17883253; rs17878900; rs1713426; rs17881356; rs1713427; rs1760933; rs3790062; rs17883795; rs17112168; rs17880290; rs12147906; rs17881554; rs17881206; rs1049700; rs17882836; rs12101049; rs17884106; rs12147035; rs34480769; rs3838361; rs3842517; rs1760939; rs17885917; rs17886095; rs1760938; rs17883294; rs17883604; rs8019880; rs17881280; rs35549071; rs35139440; rs17880503; rs7151666; rs10498268; rs1079375; rs1079376; rs11846743; rs11850059; rs11850069; rs12587218; rs12886203; rs12888804; rs12891271; rs13379232; rs13379234; rs1629478; rs17112384; rs17112385; rs1713459; rs1713460; rs1713461; rs1713462; rs17242655; rs17242662; rs17242669; rs1756365; rs1760930; rs1760931; rs1760941; rs1760942; rs2077153; rs2481768; rs35175606; rs35567022; rs7156659; rs755777

# Metabolic_Enzyme_4_General_References:
6087295; 3029074; 12928150; 2104852; 1384322; 8931706

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5937

# Metabolic_Enzyme_5_Name:
Adenosine deaminase

# Metabolic_Enzyme_5_Synonyms:
Adenosine aminohydrolase

# Metabolic_Enzyme_5_Gene_Name:
ADA

# Metabolic_Enzyme_5_Protein_Sequence:
>Adenosine deaminase
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL

# Metabolic_Enzyme_5_Number_of_Residues:
363

# Metabolic_Enzyme_5_Molecular_Weight:
40765

# Metabolic_Enzyme_5_Theoretical_pI:
5.80

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  adenosine deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_5_Specific_Function:
Adenosine + H(2)O = inosine + NH(3)

# Metabolic_Enzyme_5_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_5_Reaction:
adenosine + H2O = inosine + ammonia

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.5.4.4

# Metabolic_Enzyme_5_GenBank_ID_Protein:
28380

# Metabolic_Enzyme_5_SwissProt_ID:
ADA_HUMAN (P00813)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ADA

# Metabolic_Enzyme_5_Geneatlas_id:
ADA

# Metabolic_Enzyme_5_hgnc_id:
HGNC:186

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_5_Gene_Sequence:
>1092 bp
ATGGCCCAGACGCCCGCCTTCGACAAGCCCAAAGTAGAACTGCATGTCCACCTAGACGGA
TCCATCAAGCCTGAAACCATCTTATACTATGGCAGGAGGAGAGGGATCGCCCTCCCAGCT
AACACAGCAGAGGGGCTGCTGAACGTCATTGGCATGGACAAGCCGCTCACCCTTCCAGAC
TTCCTGGCCAAGTTTGACTACTACATGCCTGCTATCGCGGGCTGCCGGGAGGCTATCAAA
AGGATCGCCTATGAGTTTGTAGAGATGAAGGCCAAAGAGGGCGTGGTGTATGTGGAGGTG
CGGTACAGTCCGCACCTGCTGGCCAACTCCAAAGTGGAGCCAATCCCCTGGAACCAGGCT
GAAGGGGACCTCACCCCAGACGAGGTGGTGGCCCTAGTGGGCCAGGGCCTGCAGGAGGGG
GAGCGAGACTTCGGGGTCAAGGCCCGGTCCATCCTGTGCTGCATGCGCCACCAGCCCAAC
TGGTCCCCCAAGGTGGTGGAGCTGTGTAAGAAGTACCAGCAGCAGACCGTGGTGGCCATT
GACCTGGCTGGAGATGAGACCATCCCAGGAAGCAGCCTCTTGCCTGGACATGTCCAGGCC
TACCAGGAGGCTGTGAAGAGCGGCATTCACCGTACTGTCCACGCCGGGGAGGTGGGCTCG
GCCGAAGTAGTAAAAGAGGCTGTGGACATACTCAAGACAGAGCGGCTGGGACACGGCTAC
CACACCCTGGAAGACCAGGCCCTTTATAACAGGCTGCGGCAGGAAAACATGCACTTCGAG
ATCTGCCCCTGGTCCAGCTACCTCACTGGTGCCTGGAAGCCGGACACGGAGCATGCAGTC
ATTCGGCTCAAAAATGACCAGGCTAACTACTCGCTCAACACAGATGACCCGCTCATCTTC
AAGTCCACCCTGGACACTGATTACCAGATGACCAAACGGGACATGGGCTTTACTGAAGAG
GAGTTTAAAAGGCTGAACATCAATGCGGCCAAATCTAGTTTCCTCCCAGAAGATGAAAAG
AGGGAGCTTCTCGACCTGCTCTATAAAGCCTATGGGATGCCACCTTCAGCCTCTGCAGGG
CAGAACCTCTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X02994

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_5_Locus:
20q12-q13.11

# Metabolic_Enzyme_5_SNPs:
rs244076; rs11906526; rs427224; rs244078; rs2299686; rs2224999; rs379863; rs8119702; rs8119756; rs244075; rs2299691; rs2007515; rs2057637; rs762539; rs447833; rs2057638; rs6031682; rs6031690; rs6031686; rs2299688; rs6031689; rs371927; rs244079; rs2007720; rs1799880; rs2299692; rs395209; rs399159; rs2299690; rs11700291; rs929089; rs406383; rs2057639; rs967807; rs244073; rs2299694; rs452159; rs2157436; rs6031693; rs2299687; rs6017375; rs446125; rs2477898; rs6103795; rs6017378; rs445170; rs6031685; rs765215; rs6031695; rs1810751; rs2299697; rs433875; rs6031688; rs6094011; rs765216; rs244072; rs6031687; rs2299689; rs427483; rs427499; rs11907906; rs12480490; rs6103803; rs6031697; rs6017371; rs6031678; rs375379; rs384851; rs395896; rs450043; rs6094005; rs6031679; rs11698539; rs389308; rs11086932; rs6103804; rs6065738; rs1042360; rs11555566; rs7344760; rs6031698; rs394105; rs36216718; rs5841559; rs34853885; rs6017373; rs34665505; rs2765290; rs3831638; rs35553416; rs2515692; rs6031694; rs6103801; rs6103792; rs36222732; rs10561362; rs6103799; rs35009045; rs6094008; rs2007704; rs11474041; rs6103794; rs445725; rs11905649; rs6017376; rs457669; rs35383274; rs6103796; rs368253; rs6130653; rs6031691; rs11468750; rs8118045; rs6094004; rs455368; rs11484279; rs6031696; rs912912; rs6103800; rs6031684; rs445856; rs6094007; rs6017377; rs755144; rs6094009; rs11481765; rs382464; rs6103789; rs35712615; rs404898; rs6124654; rs929088; rs6031692; rs35863085; rs414146; rs6031681; rs413816; rs6103790; rs6031683; rs35436165; rs35935728; rs11698497; rs11373171; rs3091476; rs36013790; rs5841560; rs11907079; rs6103793; rs34344438; rs6017374; rs34081313; rs35535317; rs6130651; rs7353732; rs11484329; rs3041775; rs451499; rs3787359; rs11476459; rs7262528; rs6103797; rs34225524; rs11480982; rs34830340; rs6094010; rs6094006; rs3787360; rs6073497; rs11473840; rs13036408; rs34044957; rs244074; rs6103788; rs6017372; rs386512; rs35483396; rs11468701; rs2299695; rs244077; rs35505353; rs36102321; rs35545345; rs6103802; rs6103791; rs6103798; rs3831639; rs34833873; rs35784536; rs35587028; rs420183; rs6130652; rs10645831; rs36216716; rs435679; rs36216717; rs6031700; rs35153391; rs1061662; rs11699718; rs1886849; rs2071878; rs2148040; rs244081; rs244082; rs244086; rs244087; rs2664524; rs2664557; rs2664560; rs2664582; rs2664585; rs2868116; rs3180636; rs4810427; rs4810428; rs6017369; rs6031673; rs6031674; rs6031675; rs6031676; rs6031677; rs6031702; rs6031704; rs6065739; rs6094001; rs6094002; rs6094003; rs6094016; rs6094017; rs6103786; rs6103787; rs6103805; rs6103806; rs6130650; rs6130654; rs7266968; rs8118020; rs927784

# Metabolic_Enzyme_5_General_References:
6090454; 6546794; 3839456; 3028473; 11780052; 6688808; 8031011; 6208479; 3839802; 3182793; 2783588; 1284479; 8227344; 8299233; 8589684; 7599635; 9225964

# Metabolic_Enzyme_5_References:
16256072

# Macromolecular_Interacting_Partner_1_ID:
6985

# Macromolecular_Interacting_Partner_1_Name:
Adenosine A3 receptor

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
ADORA3

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Adenosine A3 receptor
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA
VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKR
VTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF
SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA
LSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC
VVCHPSDSLDTSIEKNSE

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
318

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
36185

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
9.04

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  nucleotide receptor activity, G-protein coupled
Function:  purinergic nucleotide receptor activity, G-protein coupled
Function:  adenosine receptor activity, G-protein coupled
Function:  A3 adenosine receptor activity, G-protein coupled
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
15-37
49-72
85-106
127-148
178-198
232-255
262-284

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
349449

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
AA3R_HUMAN (P33765)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
ADORA3

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
ADORA3

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:268

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>957 bp
ATGCCCAACAACAGCACTACTCTGTCATTGGCCAATGTTACCTACATCACCATGGAAATT
TTCATTGGACTCTGCGCCATAGTGGGCAACGTGCTGGTCATCTGCGTGGTCAAGCTGAAC
CCCAGCCTGCAGACCACCACCTTCTATTTCATTGTCTCTCTAGCCCTGGCTGACATTGCT
GTTGGGGTGCTGGTCATGCCTTTGGCCATTGTTGTCAGCCTGGGCATCACAATCCACTTC
TACAGCTGCCTTTTTATGACTTGCCTACTGCTTATCTTTACCCACGCCTCCATCATGTCC
TTGCTGGCCATCGCTGTGGACCGATACTTGCGGGTCAAGCTTACCGTCAGATACAAGAGG
GTCACCACTCACAGAAGAATATGGCTGGCCCTGGGCCTTTGCTGGCTGGTGTCATTCCTG
GTGGGATTGACCCCCATGTTTGGCTGGAACATGAAACTGACCTCAGAGTACCACAGAAAT
GTCACCTTCCTTTCATGCCAATTTGTTTCCGTCATGAGAATGGACTACATGGTATACTTC
AGCTTCCTCACCTGGATTTTCATCCCCCTGGTTGTCATGTGCGCCATCTATCTTGACATC
TTTTACATCATTCGGAACAAACTCAGTCTGAACTTATCTAACTCCAAAGAGACAGGTGCA
TTTTATGGACGGGAGTTCAAGACGGCTAAGTCCTTGTTTCTGGTTCTTTTCTTGTTTGCT
CTGTCATGGCTGCCTTTATCTATCATCAACTGCATCATCTACTTTAATGGTGAGGTACCA
CAGCTTGTGCTGTACATGGGCATCCTGCTGTCCCATGCCAACTCCATGATGAACCCTATC
GTCTATGCCTATAAAATAAAGAAGTTCAAGGAAACCTACCTTTTGATCCTCAAAGCCTGT
GTGGTCTGCCATCCCTCTGATTCTTTGGACACAAGCATTGAGAAGAATTCTGAGTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
L20463

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_1_Locus:
1p13.2

# Macromolecular_Interacting_Partner_1_SNPs:
rs2800889; rs35511654; rs2275797; rs2229155; rs1415792; rs1415793; rs923; rs1544223; rs3394; rs1544224; rs3393; rs7737; rs9025; rs2252739; rs2800907; rs2065992; rs1361134; rs2798566; rs2800898; rs2800908; rs2095731; rs3767602; rs7547951; rs7544118; rs1361133; rs1780556; rs6684144; rs7517018; rs12127443; rs2275796; rs17027794; rs6672858; rs6537702; rs3767601; rs1361135; rs2789539; rs2252740; rs2800888; rs6659177; rs3767597; rs2032007; rs17027796; rs2789541; rs1628597; rs7549031; rs2262952; rs2252198; rs2800906; rs3767599; rs2252197; rs2032006; rs1962125; rs2800902; rs2786996; rs10857885; rs10857886; rs10857887; rs10776728; rs11102286; rs2298191; rs10776727; rs17027791; rs35986308; rs2789537; rs17852706; rs35789323; rs1417372; rs1591993; rs41282520; rs3908963; rs41282522; rs2298190; rs2789540; rs7512445; rs10697750; rs11434724; rs11434889; rs11434726; rs12137500; rs34799830; rs11434722; rs11804136; rs28651435; rs11311759; rs6660209; rs41282516; rs12125678; rs12126504; rs6678079; rs10697753; rs35262507; rs11321711; rs10602162; rs11434888; rs11337394; rs35344043; rs34457698; rs35537319; rs6668383; rs10686710; rs10697749; rs11434890; rs34492052; rs34460629; rs10596470; rs11434725; rs35259782; rs10686711; rs10602166; rs10602160; rs35611547; rs10697748; rs10618863; rs2486265; rs41290394; rs12136686; rs28528074; rs10614217; rs11434892; rs35767792; rs12126471; rs7548753; rs35584333; rs11434723; rs1780557; rs10602164; rs3831359; rs11273132; rs28760561; rs34567608; rs34093957; rs34272338; rs10686709; rs10602163; rs10686708; rs28757604; rs41282518; rs10614218; rs11434891; rs2488943; rs35689000; rs34693250; rs11314583; rs3835605; rs2265691; rs11102285; rs3216055; rs34273340; rs10711590; rs3904838; rs34622560; rs5777061; rs35606913; rs34225315; rs35077141; rs1054680; rs10857888; rs10857889; rs10857890; rs11102281; rs11102284; rs11102290; rs11102291; rs11102292; rs11576988; rs11810580; rs12039025; rs12042310; rs12142663; rs12566343; rs1361136; rs1419091; rs1538251; rs17027773; rs17027867; rs17027880; rs2211494; rs2298189; rs2786992; rs2786994; rs2786995; rs2800886; rs4593826; rs4839139; rs6537704; rs6537705; rs6692745; rs6703267

# Macromolecular_Interacting_Partner_1_General_References:
8399349; 8234299; 12975309; 11214319

# Macromolecular_Interacting_Partner_1_References:
16033270; 16305531; 17149867

# Macromolecular_Interacting_Partner_2_ID:
8758

# Macromolecular_Interacting_Partner_2_Name:
Equilibrative nucleoside transporter 2

# Macromolecular_Interacting_Partner_2_Synonyms:
Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter; Equilibrative NBMPR-insensitive nucleoside transporter; Nucleoside transporter, ei-type; Solute carrier family 29 member 2; 36 kDa nucleolar protein HNP36; Hydrophobic nucleolar protein, 36 kDa; Delayed-early response protein 12

# Macromolecular_Interacting_Partner_2_Gene_Name:
SLC29A2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Equilibrative nucleoside transporter 2
MARGDAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGNSTARILSTNHTG
PEDAFNFNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGSLLAILLLFALTAALVKVD
MSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLL
SMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQELETKAE
LLQSDENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLV
FTVTLSVFPAITAMVTSSTSPGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRL
LPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPR
QVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
456

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
50114

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.02

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_2_Signals:
1-24

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
13-33
70-90
99-119
124-144
162-182
193-213
291-311
324-344
360-380
386-406
432-452

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
2811137

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
S29A2_HUMAN (Q14542)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
SLC29A2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
SLC29A2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:11004

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Isoform 1:Cell membrane; multi-pass membrane protein. Isoform 2:Nucleus; nuclear membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1371 bp
ATGGCGCGAGGAGACGCCCCGCGGGACAGCTACCACCTGGTCGGGATCAGCTTCTTCATC
CTGGGGCTGGGCACCCTCCTTCCCTGGAACTTCTTCATCACCGCCATCCCGTACTTCCAG
GCGCGACTGGCCGGGGCCGGCAACAGCACAGCCAGGATCCTGAGCACCAACCACACGGGT
CCCGAGGATGCCTTCAACTTCAACAATTGGGTGACGCTGCTGTCCCAGCTGCCCCTGCTG
CTCTTCACCCTCCTCAACTCCTTCCTGTACCAGTGCGTCCCGGAGACGGTGCGCATTCTG
GGCAGCCTGCTGGCCATACTGCTGCTCTTTGCCCTGACAGCAGCGCTGGTCAAGGTGGAC
ATGAGCCCCGGACCCTTCTTCTCCATCACCATGGCCTCCGTCTGCTTCATCAACTCCTTC
AGTGCAGTCCTACAGGGCAGCCTCTTCGGGCAGCTGGGCACCATGCCCTCCACCTACAGC
ACCCTCTTCCTCAGCGGCCAGGGCCTGGCTGGGATCTTTGCTGCCCTTGCCATGCTCCTG
TCCATGGCCAGTGGCGTGGACGCCGAGACCTCTGCCCTGGGGTACTTTATCACGCCCTGT
GTGGGCATCCTCATGTCCATCGTGTGTTACCTGAGCCTGCCTCACCTGAAGTTTGCCCGC
TACTACCTGGCCAATAAATCATCCCAGGCCCAAGCTCAGGAGCTGGAGACCAAAGCTGAG
CTCCTCCAGTCTGATGAGAACGGGATTCCCAGTAGTCCCCAGAAAGTAGCTCTGACCCTG
GATCTTGACCTGGAGAAGGAGCCGGAATCAGAGCCAGATGAGCCCCAGAAGCCAGGAAAA
CCTTCAGTCTTCACTGTCTTCCAGAAGATCTGGCTGACAGCGCTGTGCCTTGTGTTGGTC
TTCACAGTCACCCTGTCCGTCTTCCCCGCCATCACAGCCATGGTGACCAGCTCCACCAGT
CCTGGGAAGTGGAGTCAGTTCTTCAACCCCATCTGCTGCTTCCTCCTCTTCAACATCATG
GACTGGCTGGGACGGAGCCTGACCTCTTACTTCCTGTGGCCAGACGAGGACAGCCGGCTG
CTGCCCCTGCTGGTCTGCCTGCGGTTCCTGTTCGTGCCCCTCTTCATGCTGTGCCACGTG
CCCCAGAGGTCCCGGCTGCCCATCCTCTTCCCACAGGATGCCTACTTCATCACCTTCATG
CTGCTCTTTGCCGTTTCTAATGGCTACCTGGTGTCCCTCACCATGTGCCTGGCGCCCAGG
CAGGTGCTGCCACACGAGAGGGAGGTGGCCGGCGCCCTCATGACCTTCTTCCTGGCCCTG
GGACTTTCCTGTGGAGCCTCCCTCTCCTTCCTCTTCAAGGCGCTGCTCTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AF034102

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_2_Locus:
11q13

# Macromolecular_Interacting_Partner_2_SNPs:
rs8187661; rs1039593; rs3177514; rs4930358; rs7126064; rs2292123; rs2279861; rs2279862; rs7125100; rs7126018; rs12416747; rs1039594; rs10791872; rs8187658; rs3867130; rs12576299; rs1344410; rs12576293; rs12577196; rs4930178; rs4930359; rs12281049; rs4244813; rs7107191; rs7104297; rs17850744; rs17855425; rs12801227; rs34186490; rs34124904; rs11227466; rs4554890; rs3741366; rs10605893; rs11403442; rs7111197; rs10632640; rs35639157; rs35962792; rs7946434; rs33943132; rs34029417; rs1815807; rs35659701; rs7103571; rs35791794; rs10648232; rs11423263; rs34482391; rs1566871; rs11298226; rs12800796; rs35509820; rs11461356; rs35457397; rs1201452; rs1210071; rs34585457; rs12360603; rs1047029; rs10791871; rs12794121; rs34272485; rs7130857; rs8187644; rs8187646; rs8187647; rs8187657; rs8187659; rs8187660

# Macromolecular_Interacting_Partner_2_General_References:
9478986; 9396714; 7639753

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8857

# Macromolecular_Interacting_Partner_3_Name:
Equilibrative nucleoside transporter 3

# Macromolecular_Interacting_Partner_3_Synonyms:
Solute carrier family 29 member 3

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC29A3

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Equilibrative nucleoside transporter 3
MAVVSEDDFQHSSNSTYRTTSSSLRADQEALLEKLLDRPPPGLQRPEDRFCGTYIIFFSL
GIGSLLPWNFFITAKEYWMFKLRNSSSPATGEDPEGSDILNYFESYLAVASTVPSMLCLV
ANFLLVNRVAVHIRVLASLTVILAIFMVITALVKVDTFSWTRGFFAVTIVCMVILSGAST
VFSSSIYGMTGSFPMRNSQALISGGAMGGTVSAVASLVDLAASSDVRNSALAFFLTATIF
LVLCMGLYLLLSRLEYARYYMRPVLAAHVFSGEEELPQDSLSAPSVASRFIDSHTPPLRP
ILKKTASLGFCVTYVFFITSLIYPAVCTNIESLNKGSGSLWTTKFFIPLTTFLLYNFADL
CGRQLTAWIQVPGPNSKALPGFVLLRTCLIPLFVLCNYQPRVHLKTVVFQSDVYPALLSS
LLGLSNGYLSTLALLYGPKIVPRELAEATGVVMSFYVCLGLTLGSACSTLLVHLI

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
475

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
51875

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
7.85

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
 Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter)

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_3_Signals:
Not Available

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
50-72
107-126
131-153
163-185
198-220
230-252
308-330
340-357
378-395
415-437
450-472

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
12656639

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
S29A3_HUMAN (Q9BZD2)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC29A3

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC29A3

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:23096

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1428 bp
ATGGCCGTTGTCTCAGAGGACGACTTTCAGCACAGTTCAAACTCCACCTACAGAACCACA
AGCAGCAGTCTCCGAGCTGACCAGGAGGCACTGCTTGAGAAGCTGCTGGACCGCCCGCCC
CCTGGCCTGCAGAGGCCCGAGGACCGCTTCTGTGGCACATACATCATCTTCTTCAGCCTG
GGCATTGGCAGTCTACTGCCATGGAACTTCTTTATCACTGCCAAGGAGTACTGGATGTTC
AAACTCCGCAACTCCTCCAGCCCAGCCACCGGGGAGGACCCTGAGGGCTCAGACATCCTG
AACTACTTTGAGAGCTACCTTGCCGTTGCCTCCACCGTGCCCTCCATGCTGTGCCTGGTG
GCCAACTTCCTGCTTGTCAACAGGGTTGCAGTCCACATCCGTGTCCTGGCCTCACTGACG
GTCATCCTGGCCATCTTCATGGTGATAACTGCACTGGTGAAGGTGGACACTTTCTCCTGG
ACCCGTGGCTTTTTTGCGGTCACCATTGTCTGCATGGTGATCCTCAGCGGTGCCTCCACT
GTCTTCAGCAGCAGCATCTACGGCATGACCGGCTCCTTTCCTATGAGGAACTCCCAGGCA
CTGATATCAGGAGGAGCCATGGGCGGGACGGTCAGCGCCGTGGCCTCATTGGTGGACTTG
GCTGCATCCAGTGATGTGAGGAACAGCGCCCTGGCCTTCTTCCTGACGGCCACCATCTTC
CTCGTGCTCTGCATGGGACTCTACCTGCTGCTGTCCAGGCTGGAGTATGCCAGGTACTAC
ATGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGAAGAGGAGCTTCCCCAGGACTCC
CTCAGTGCCCCTTCGGTGGCCTCCAGATTCATTGATTCCCACACACCCCCTCTCCGCCCC
ATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGTCTTCTTCATCACCAGC
CTCATCTACCCCGCCGTCTGCACCAACATCGAGTCCCTCAACAAGGGCTCGGGCTCACTG
TGGACCACCAAGTTTTTCATCCCCCTCACTACCTTCCTCCTGTACAACTTTGCTGACCTA
TGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAATAGCAAGGCGCTCCCA
GGGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTTCGTGCTCTGTAACTACCAGCCC
CGCGTCCACCTGAAGACTGTGGTCTTCCAGTCCGATGTGTACCCCGCACTCCTCAGCTCC
CTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCTCTACGGGCCTAAGATT
GTGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGATGTCCTTTTATGTGTGCTTGGGC
TTAACACTGGGCTCAGCCTGCTCTACCCTCCTGGTGCACCTCATCTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF326987

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_3_Locus:
10q22.1

# Macromolecular_Interacting_Partner_3_SNPs:
rs2487068; rs2252996; rs780668; rs2277257; rs999940; rs16928737; rs2252997; rs1084004; rs2275579; rs780680; rs780664; rs1538899; rs780660; rs780659; rs780666; rs703257; rs780654; rs946875; rs703256; rs2394793; rs7069807; rs1110399; rs780677; rs4600131; rs780675; rs2243460; rs780670; rs780676; rs6480510; rs2487067; rs6480511; rs809691; rs883764; rs7086724; rs12256138; rs2012500; rs780662; rs4494244; rs780672; rs780653; rs3781314; rs2249987; rs1538895; rs2066211; rs780655; rs10823723; rs1316421; rs11815656; rs3824770; rs7100381; rs2250002; rs6480513; rs12251921; rs12767108; rs16928705; rs10999773; rs10999778; rs1572810; rs7076329; rs6480514; rs780667; rs7090745; rs2249882; rs883763; rs780679; rs780674; rs7080325; rs3781316; rs2249989; rs780678; rs11812689; rs780669; rs2487066; rs2243496; rs7067629; rs10999776; rs7095417; rs11594628; rs780665; rs4430425; rs4348816; rs780661; rs3781311; rs3781313; rs2249753; rs10999770; rs7091983; rs884031; rs3781324; rs780658; rs10999775; rs7072838; rs780671; rs946973; rs10740374; rs12252326; rs3781310; rs10999771; rs3781309; rs3781312; rs1890885; rs2243540; rs3758570; rs3781317; rs2066209; rs780656; rs7900534; rs7083031; rs2066210; rs6480512; rs12220541; rs884681; rs3781327; rs16928722; rs7068179; rs7090777; rs12249513; rs10740375; rs7913673; rs780673; rs10999777; rs10999781; rs780657; rs7090611; rs884680; rs3781326; rs7086520; rs7071162; rs7071738; rs2249752; rs12252139; rs17525188; rs12252279; rs2243485; rs7071979; rs10999772; rs3781325; rs7087714; rs7084342; rs4747148; rs7924115; rs946979; rs780681; rs1572812; rs35065420; rs6650127; rs34069552; rs10716665; rs35206666; rs12263170; rs10625840; rs34905233; rs11376986; rs35919163; rs5786035; rs34110374; rs12356731; rs35335105; rs12269478; rs12243734; rs34152212; rs7913062; rs3059614; rs12762394; rs7911708; rs7914132; rs4746081; rs7094989; rs35701283; rs12267767; rs12220170; rs7068296; rs34294547; rs35368644; rs41281300; rs3781318; rs4641383; rs7916422; rs34315182; rs10999774; rs35720104; rs10999769; rs35239123; rs7077024; rs3837344; rs7913610; rs10552605; rs10999779; rs780663; rs35509882; rs3893272; rs3059612; rs35156362; rs1609652; rs35485497; rs34058912; rs12243650; rs4147262; rs7903407; rs35942216; rs12763826; rs3837345; rs34297699; rs34965758; rs3824768; rs34491538; rs41300554; rs36074226; rs7095479; rs7067937; rs11296364; rs35855172; rs7897272; rs34640546; rs3781315; rs34395748; rs12355187; rs12261581; rs10686987; rs12779065; rs10999783; rs36087675; rs12762772; rs5786034; rs10999782; rs34650529; rs34632350; rs10553895; rs34721394; rs12249991; rs11593088; rs3059610; rs28708771; rs35956296; rs10999768; rs28688626; rs35685893; rs10823722; rs10999766; rs10999784; rs10999785; rs10999786; rs10999788; rs11595617; rs11816935; rs12098507; rs12254223; rs12412201; rs12414898; rs1538898; rs1609651; rs17546494; rs2185416; rs2248674; rs34217506; rs35016944; rs35685474; rs7079524; rs780682; rs780683; rs780687; rs780688; rs780689; rs780690; rs780692; rs780693; rs780694; rs780695; rs780697; rs780698; rs7895122; rs7899555; rs869545; rs946879

# Macromolecular_Interacting_Partner_3_General_References:
11396612; 12384580; 12975309

# Macromolecular_Interacting_Partner_3_References:
Not Available

End of HMDB00034

Beginning of HMDB00036
# Accession_No:
HMDB00036

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-07-17 14:06:26

# biospider_lastupdate:
2007-07-24 17:08:12

# Common_Name:
Taurocholic acid

# Description:
Taurocholic acid is the product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic (a bile purging agent). Hydrolysis of taurocholic acid yields taurine, a nonessential amino acid.
Taurocholic acid is one of the main components of urinary nonsulfated bile acids in Biliary Atresia. Raised levels of the bile acid taurocholate in the fetal serum in obstetric cholestasis may result in the development of a fetal dysrhythmia and in sudden intra-uterine death. (PMID: 3944741, 11256973)
A bile acid. Bile acids are steroid acids found predominantly in bile of mammals. The distinction between different bile acids is minute, depends only on presence or absence of hydroxyl groups on positions 3, 7, and 12. 
Bile acids are physiological detergents that facilitate excretion, absorption, and transport of fats and sterols in the intestine and liver. Bile acids are also steroidal amphipathic molecules derived from the catabolism of cholesterol. They modulate bile flow and lipid secretion, are essential for the absorption of dietary fats and vitamins, and have been implicated in the regulation of all the key enzymes involved in cholesterol homeostasis. 
Bile acids recirculate through the liver, bile ducts, small intestine and portal vein to form an enterohepatic circuit. They exist as anions at physiological pH and, consequently, require a carrier for transport across the membranes of the enterohepatic tissues. The unique detergent properties of bile acids are essential for the digestion and intestinal absorption of hydrophobic nutrients. Bile acids have potent toxic properties (e.g., membrane disruption) and there are a plethora of mechanisms to limit their accumulation in blood and tissues. (PMID: 11316487, 16037564, 12576301, 11907135)


# Synonyms:
3a,7a,12a-Trihydroxy-5b-cholanic acid-24-taurine; Cholaic acid; Cholic acid taurine conjugate; Cholyltaurine; N-Choloyltaurine; n-choloyl-Taurine

# Chemical_IUPAC_Name:
2-[4-[(3R,5S,7R,12S)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid

# Chemical_Formula:
C26H45NO7S

# Chemical_Structure:
tbl_chemical:::HMDB00036_ZOOM.png:::119283146132157772

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00036_THUMB.png:::119283145913587514

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Bile Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
sulfonic acid; secondary carboxylic acid amide; secondary alcohol

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
515.29163

# Molecular_Weight_Avg:
515.70300

# Smiles_String_isomeric:
CC(CCC(=O)NCCS(O)(=O)=O)C1CCC2C3[C@H](O)C[C@@H]4C[C@H](O)CCC4(C)C3C[C@H](O)C12C

# Smiles_String_canonical:
CC(CCC(=O)NCCS(O)(=O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C

# KEGG_Compound_ID:
C05122

# BioCyc_ID:
CPD-3743

# PubChem_CID:
440567

# PubChem_SID:
7544

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
45150

# Wikipedia_ID:
Taurocholate

# METLIN_ID:
5104

# Ref_ID:
8359688; 7913319; 9322525; 12891557; 16178789; 9508530; 10480314; 16014767; 12631271; 10100884; 12883481; 16606610; 2757635; 11927623; 11160372; 3683732; 11408531; 16078136

# ChEBI_ID:
28865

# CAS_Registry_Number:
81-24-3

# InChI:
InChI=1/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/t15?,16-,17+,18?,19?,20?,21+,22-,24?,25?,26?/m0/s1

# Synthesis_Reference:
Not Available

# Melting_Point:
125 oC

# Melting_Point_predicted:
167.8 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
7.17 mg/mL [MEYLAN,WM et al. (1996)]; 0.0771 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
0.79 [Predicted by ALOGPS]; 2.7 [Predicted by PubChem via XLOGP]; 0.01 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00036_msds.html:::1132562192197607836

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C05122.mol:::1132723802687473294

# SDF_File_[Text]:
tbl_chemical:::HMDB00036.sdf:::119283145231260128

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00036.pdb:::119283145740282670

# PDB_ID:
1AQL

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1AQL.txt:::1132720899375129179

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::7-Epicholic acid.gif:::1132732101218673419

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00036_peaks.txt:::1156309501819829201

# Predicted_C_NMR_Spectrum:
tbl_chemical:::7-Epicholic acid_C.gif:::1132737663816572184

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00036_peaks.txt:::1156310693510858719

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane; Cytoplasm; Extracellular; peroxisome

# Tissue_Location:
Fibroblasts; Hepatocyte; Intestine; Liver; Liver Predominantly; Myelin

# deuterated:
No

# Biofluid_Location:
Bile; Blood

# Concentration_[Normal]:
Blood	0.20	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Bile	9910 (9600-10220)	uM	Adult:>18_yrs_old	Both	Normal	11160372


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Acute Pancreatitis; Cholestasis

# Pathway_Names:
Bile acid biosynthesis

# Pathway_Images:
Not Available

# KEGG_Images:
map00120

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5821

# Metabolic_Enzyme_1_Name:
Bile acid CoA:amino acid N-acyltransferase

# Metabolic_Enzyme_1_Synonyms:
BAT; BACAT; Glycine N-choloyltransferase; Long-chain fatty-acyl-CoA hydrolase

# Metabolic_Enzyme_1_Gene_Name:
BAAT

# Metabolic_Enzyme_1_Protein_Sequence:
>Bile acid CoA:amino acid Nacyltransferase
MIQLTATPVSALVDEPVHIRATGLIPFQMVSFQASLEDENGDMFYSQAHYRANEFGEVDL
NHASSLGGDY
MGVHPMGLFWSLKPEKLLTRLLKRDVMNRPFQVQVKLYDLELIVNNKVA
SAPKASLTLERWYVAPGVTRI
KVREGRLRGALFLPPGEGLFPGVIDLFGGLGGLLEFRA
SLLASRGFASLALAYHNYEDLPRKPEVTDLEY
FEEAANFLLRHPKVFGSGVGVVSVCQG
VQIGLSMAIYLKQVTATVLINGTNFPFGIPQVYHGQIHQPLPH
SAQLISTNALGLLELY
RTFETTQVGASQYLFPIEEAQGQFLFIVGEGDKTINSKAHAEQAIGQLKRHGKN
NWTLL
SYPGAGHLIEPPYSPLCCASTTHDLRLHWGGEVIPHAAAQEHAWKEIQRFLRKHLIPDVT
SQL

# Metabolic_Enzyme_1_Number_of_Residues:
418

# Metabolic_Enzyme_1_Molecular_Weight:
46300

# Metabolic_Enzyme_1_Theoretical_pI:
7.00

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  thiolester hydrolase activity
Function:  CoA hydrolase activity
Function:  palmitoyl-CoA hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs

# Metabolic_Enzyme_1_Pathway:
map00120  Bile acid biosynthesis;
 map00430  Taurine and hypotaurine metabolism

# Metabolic_Enzyme_1_Reaction:
palmitoyl-CoA + H2O = CoA + palmitate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF08840:BAAT_C;
PF04775:Bile_Hydr_Trans

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.3.1.65;EC 3.1.2.2

# Metabolic_Enzyme_1_GenBank_ID_Protein:
532505

# Metabolic_Enzyme_1_SwissProt_ID:
BAAT_HUMAN (Q14032)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
BAAT

# Metabolic_Enzyme_1_Geneatlas_id:
BAAT

# Metabolic_Enzyme_1_hgnc_id:
HGNC:932

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1257 bp

ATGATCCAGTTGACAGCTACCCCTGTGAGTGCACTTGTTGATGAGCCAGTGCATATCCG
AGCTACAGGCC
TGATTCCCTTTCAGATGGTGAGTTTTCAGGCATCACTGGAAGATGAAA
ACGGAGACATGTTTTATTCTCA
AGCCCACTATAGGGCCAATGAATTCGGTGAGGTGGAC
CTGAATCATGCTTCTTCACTTGGAGGGGATTAT
ATGGGAGTCCACCCCATGGGTCTCTT
CTGGTCTCTGAAACCTGAAAAGCTATTAACAAGACTGTTGAAAA
GAGATGTGATGAATA
GGCCTTTCCAGGTCCAAGTAAAACTTTATGACTTAGAGTTAATAGTGAACAATAA
AGTT
GCCAGTGCTCCAAAGGCCAGCCTGACTTTGGAGAGGTGGTATGTGGCACCTGGTGTCACA
CGAATT
AAGGTTCGAGAAGGCCGCCTTCGAGGAGCTCTCTTTCTCCCTCCAGGAGAGGG
TCTCTTCCCAGGGGTAA
TTGATTTGTTTGGTGGTTTGGGTGGGCTGCTTGAATTTCGGG
CCAGCCTCCTAGCCAGTCGTGGCTTCGC
CTCCTTGGCCTTGGCTTACCATAACTATGAA
GACCTGCCCCGCAAACCAGAAGTAACAGATTTGGAATAT
TTTGAGGAGGCTGCCAACTT
TCTCCTGAGACATCCAAAGGTCTTTGGCTCAGGCGTTGGGGTAGTCTCTG
TATGTCAAG
GAGTACAGATTGGACTATCTATGGCTATTTACCTAAAGCAAGTCACAGCCACGGTACTTA
T
TAATGGGACCAACTTTCCTTTTGGCATTCCACAGGTATATCATGGTCAGATCCATCAG
CCCCTTCCCCAT
TCTGCACAATTAATATCCACCAATGCCTTGGGGTTACTAGAGCTCTA
TCGCACTTTTGAGACAACTCAAG
TTGGGGCCAGTCAATATTTGTTTCCTATTGAAGAGG
CCCAGGGGCAATTCCTCTTCATTGTAGGAGAAGG
TGATAAGACTATCAACAGCAAAGCA
CACGCTGAACAAGCCATAGGACAGCTGAAGAGACATGGGAAGAAC
AACTGGACCCTGCT
ATCTTACCCTGGGGCAGGCCACCTGATAGAACCTCCCTATTCTCCTCTGTGCTGTG
CCT
CAACGACCCACGATTTGAGGTTACACTGGGGAGGAGAGGTGATCCCACACGCAGCTGCAC
AGGAACA
TGCTTGGAAGGAGATCCAGAGATTTCTCAGGAAGCACCTCATTCCAGATGTG
ACCAGTCAACTCTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
L34081

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_1_Locus:
9q22.3

# Metabolic_Enzyme_1_SNPs:
rs1572983; rs1226149; rs7043029; rs1226148; rs2229594; rs3824471; rs10819923; rs11791228; rs1226146; rs1891218; rs16936057; rs11560557; rs11496612; rs1226147; rs10120345; rs13294625; rs1341762; rs7048634; rs1341761; rs11792588; rs10989484; rs11788495; rs7848855; rs10114241; rs1341760; rs2417252; rs1341763; rs10760793; rs16920259; rs12336316; rs12350797; rs12351725; rs12338315; rs2417251; rs12341413; rs4322060; rs16920270; rs11793528; rs1226151; rs10118584; rs10123392; rs1226150; rs28937579; rs41281027; rs34425366; rs34962203; rs35281640; rs35538457; rs41274983; rs41281023; rs34155990; rs34005912; rs1135370; rs12115514; rs41274981; rs35109318; rs11351334; rs5899439; rs1057381; rs3847297; rs11420217; rs41281025; rs28599990; rs11524206; rs34334602; rs41301517; rs41316534; rs1057380; rs11433573; rs4595182; rs28447257; rs11349375; rs12350768; rs12379847; rs33919057; rs34003904; rs7037661; rs3081772; rs12004919; rs10989483; rs12341591; rs34603354; rs12683613; rs10124497; rs10989481; rs10989485; rs34755395; rs34701662; rs34724095; rs34197213; rs10123365; rs35371378; rs10989482; rs11787566; rs10122439; rs12342218; rs10119499; rs10120225; rs10118966; rs10819924; rs10989478; rs10989480; rs10989486; rs11790161; rs11793356; rs11793745; rs11795072; rs11795175; rs12348863; rs12376826; rs16920288; rs1857027; rs4742813; rs7023837; rs7023948; rs7023972; rs7033167; rs7847420

# Metabolic_Enzyme_1_General_References:
8034703; 12704386

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5297

# Metabolic_Enzyme_2_Name:
85 kDa calcium-independent phospholipase A2

# Metabolic_Enzyme_2_Synonyms:
iPLA2; CaI- PLA2; Group VI phospholipase A2; GVI PLA2

# Metabolic_Enzyme_2_Gene_Name:
PLA2G6

# Metabolic_Enzyme_2_Protein_Sequence:
>85 kDa calciumindependent phospholipase A2
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLV
NPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSW
SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD
VTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL
LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA
RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK
DNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHG
VPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTHDHL
LCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGM
YFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFR
NYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNP
TLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKT
VFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVN
ALWETEVYIYEHREEFQKLIQLLLSP

# Metabolic_Enzyme_2_Number_of_Residues:
806

# Metabolic_Enzyme_2_Molecular_Weight:
89904

# Metabolic_Enzyme_2_Theoretical_pI:
7.28

# Metabolic_Enzyme_2_GO_Classification:
Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity

# Metabolic_Enzyme_2_Pathway:
map00564  Glycerophospholipid metabolism;
 map00590  Prostaglandin and leukotriene metabolism

# Metabolic_Enzyme_2_Reaction:
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00023:Ank

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.1.1.4

# Metabolic_Enzyme_2_GenBank_ID_Protein:
3142700

# Metabolic_Enzyme_2_SwissProt_ID:
PA2G6_HUMAN (O60733)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
PLA2G6

# Metabolic_Enzyme_2_Geneatlas_id:
PLA2G6

# Metabolic_Enzyme_2_hgnc_id:
HGNC:9039

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Isoform LH-iPLA2:Membrane; peripheral membrane protein. Isoform SH-iPLA2:Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>2421 bp
ATGCAGTTCTTTGGCCGCCTGGTCAATACCTTCAGTGGCGTCACCAACTTGTTCTCTAAC
CCATTCCGGGTGAAGGAGGTGGCTGTGGCCGACTACACCTCGAGTGACCGAGTTCGGGAG
GAAGGGCAGCTGATTCTGTTCCAGAACACTCCCAACCGCACCTGGGACTGCGTCCTGGTC
AACCCCAGGAACTCACAGAGTGGATTCCGACTCTTCCAGCTGGAGTTGGAGGCTGACGCC
CTAGTGAATTTCCATCAGTATTCTTCCCAGCTGCTACCCTTCTATGAGAGCTCCCCTCAG
GTCCTGCACACTGAGGTCCTGCAGCACCTGACCGACCTCATCCGTAACCACCCCAGCTGG
TCAGTGGCCCACCTGGCTGTGGAGCTAGGGATCCGCGAGTGCTTCCATCACAGCCGTATC
ATCAGCTGTGCCAATTGCGCGGAGAACGAGGAGGGCTGCACACCCCTGCACCTGGCCTGC
CGCAAGGGTGATGGGGAGATCCTGGTGGAGCTGGTGCAGTACTGCCACACTCAGATGGAT
GTCACCGACTACAAGGGAGAGACCGTCTTCCATTATGCTGTCCAGGGTGACAATTCTCAG
GTGCTGCAGCTCCTTGGAAGGAACGCAGTGGCTGGCCTGAACCAGGTGAATAACCAAGGG
CTGACCCCGCTGCACCTGGCCTGCCAGCTGGGGAAGCAGGAGATGGTCCGCGTGCTGCTG
CTGTGCAATGCTCGGTGCAACATCATGGGCCCCAACGGCTACCCCATCCACTCGGCCATG
AAGTTCTCTCAGAAGGGGTGTGCGGAGATGATCATCAGCATGGACAGCAGCCAGATCCAC
AGCAAAGACCCCCGTTACGGAGCCAGCCCCCTCCACTGGGCCAAGAACGCAGAGATGGCC
CGCATGCTGCTGAAACGGGGCTGCAACGTGAACAGCACCAGCTCCGCGGGGAACACGGCC
CTGCACGTGGCGGTGATGCGCAACCGCTTCGACTGTGCCATAGTGCTGCTGACCCACGGG
GCCAACGCGGATGCCCGCGGAGAGCACGGCAACACCCCGCTGCACCTGGCCATGTCGAAA
GACAACGTGGAGATGATCAAGGCCCTCATCGTGTTCGGAGCAGAAGTGGACACCCCGAAT
GACTTTGGGGAGACTCCTACATTCCTAGCCTCCAAAATCGGCAGACTTGTCACCAGGAAG
GCGATCTTGACTCTGCTGAGAACCGTGGGGGCCGAATACTGCTTCCCACCCATCCACGGG
GTCCCCGCGGAGCAGGGCTCTGCAGCGCCACATCATCCCTTCTCCCTGGAAAGAGCTCAG
CCCCCACCGATCAGCCTAAACAACCTAGAACTACAGGATCTCATGCACATCTCACGGGCC
CGGAAGCCAGCGTTCATCCTGGGCTCCATGAGGGACGAGAAGCGGACCCACGACCACCTG
CTGTGCCTGGATGGAGGAGGAGTGAAAGGCCTCATCATCATCCAGCTCCTCATCGCCATC
GAGAAGGCCTCGGGTGTGGCCACCAAGGACCTGTTTGACTGGGTGGCGGGCACCAGCACT
GGAGGCATCCTGGCCCTGGCCATTCTGCACAGTAAGTCCATGGCCTACATGCGCGGCATG
TACTTTCGCATGAAGGATGAGGTGTTCCGGGGCTCCAGGCCCTACGAGTCGGGGCCCCTG
GAGGAGTTCCTGAAGCGGGAGTTTGGGGAGCACACCAAGATGACGGACGTCAGGAAACCC
AAGGTGATGCTGACAGGGACACTGTCTGACCGGCAGCCGGCTGAACTCCACCTCTTCCGG
AACTACGATGCTCCAGAAACTGTCCGGGAGCCTCGTTTCAACCAGAACGTTAACCTCAGG
CCTCCAGCTCAGCCCTCAGACCAGCTGGTGTGGCGGGCGGCCCGAAGCAGCGGGGCAGCT
CCTACTTACTTCCGACCCAATGGGCGCTTCCTGGACGGTGGGCTGCTGGCCAACAACCCC
ACGCTGGATGCCATGACCGAGATCCATGAGTACAATCAGGACCTGATCCGCAAGGGTCAG
GCCAACAAGGTGAAGAAACTCTCCATCGTTGTCTCCCTGGGGACAGGGAGGTCCCCACAA
GTGCCTGTGACCTGTGTGGATGTCTTCCGTCCCAGCAACCCCTGGGAGCTGGCCAAGACT
GTTTTTGGGGCCAAGGAACTGGGCAAGATGGTGGTGGACTGTTGCACGGATCCAGACGGG
CGGGCTGTGGACCGGGCACGGGCCTGGTGCGAGATGGTCGGCATCCAGTACTTCAGATTG
AACCCCCAGCTGGGGACGGACATCATGCTGGATGAGGTCAGTGACACAGTGCTGGTCAAC
GCCCTCTGGGAGACCGAGGTCTACATCTATGAGCACCGCGAGGAGTTCCAGAAGCTCATC
CACCTGCTGCTCTCACCCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF064594

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_2_Locus:
22q13.1

# Metabolic_Enzyme_2_SNPs:
rs11570606; rs11570680; rs11570605; rs2413502; rs11570679; rs2267369; rs4384; rs2267371; rs133029; rs133006; rs2277844; rs2267370; rs738322; rs133007; rs4378; rs2413503; rs133009; rs738321; rs738320; rs132991; rs4379; rs133012; rs132989; rs9610911; rs133017; rs133014; rs132995; rs132998; rs11570601; rs738323; rs6001045; rs133019; rs9306323; rs4380; rs2092180; rs133008; rs133013; rs133015; rs132999; rs9610910; rs4385; rs132992; rs75387; rs133016; rs132994; rs133021; rs4381; rs4382; rs133018; rs11570598; rs132993; rs133001; rs133022; rs132996; rs5756947; rs6001037; rs133003; rs11570602; rs4820318; rs8142004; rs132997; rs4383; rs6001038; rs133023; rs4820320; rs11570599; rs6001040; rs16998801; rs11570603; rs133024; rs132985; rs132966; rs2076112; rs2016755; rs731821; rs9619724; rs2076118; rs5750542; rs6001030; rs132946; rs84473; rs1807559; rs4987198; rs6001029; rs4820314; rs2005974; rs4821751; rs2284066; rs6001034; rs4821740; rs3827354; rs6001031; rs3788535; rs3891103; rs2267367; rs2235346; rs8135333; rs7286105; rs5756921; rs4375; rs2284062; rs3788532; rs4820317; rs6001020; rs2076116; rs2076113; rs6001026; rs6001014; rs2012725; rs2235345; rs6001033; rs5756931; rs4821746; rs5756940; rs2235347; rs3788536; rs1807712; rs5750546; rs3788533; rs2267368; rs132954; rs5756922; rs2076117; rs11570645; rs9622746; rs6001028; rs6001022; rs132976; rs738317; rs4376; rs5756934; rs132941; rs6001027; rs2284059; rs8135937; rs2076115; rs11570753; rs132972; rs11570734; rs2272831; rs11570641; rs4497; rs736129; rs132979; rs11089864; rs11570681; rs5995538; rs132987; rs11570736; rs11570651; rs11570658; rs2284063; rs132988; rs6001018; rs132977; rs4377; rs11570682; rs11089868; rs132975; rs132944; rs3900948; rs4821741; rs2235344; rs6001023; rs4821747; rs2018663; rs3788534; rs2072867; rs11570724; rs11570761; rs132973; rs3827355; rs4987197; rs11570710; rs5750547; rs10427700; rs132953; rs11570678; rs11570666; rs6001021; rs11570647; rs10483197; rs6001035; rs2284067; rs5756926; rs5750549; rs5756932; rs6001015; rs132960; rs11570690; rs5756929; rs2076114; rs4820315; rs132986; rs2284060; rs12485185; rs132952; rs11570649; rs132959; rs9622732; rs7290177; rs11570608; rs11570739; rs11570762; rs11570717; rs10427916; rs11570737; rs132964; rs11570701; rs11570721; rs11570660; rs132969; rs9622738; rs11570670; rs11570744; rs12167576; rs132982; rs11570683; rs11266975; rs5995542; rs9622743; rs2284061; rs132978; rs5750548; rs11570750; rs11570707; rs11570687; rs11570667; rs11089869; rs6001036; rs5750544; rs132974; rs11570751; rs11570727; rs11570630; rs11913405; rs132984; rs11570639; rs4821742; rs11570732; rs11570635; rs5756933; rs4820316; rs5756930; rs11912233; rs11570674; rs11570677; rs11570609; rs10427908; rs2284065; rs11570715; rs11570748; rs11704062; rs11570730; rs133010; rs2179236; rs11570662; rs4821743; rs132970; rs11570714; rs6001019; rs16998769; rs11570726; rs11570657; rs11570713; rs11570614; rs16998759; rs11570745; rs5750543; rs4987199; rs11570709; rs11570672; rs11570696; rs11570700; rs11570668; rs11570722; rs16998753; rs11570747; rs11570728; rs11570684; rs11570638; rs132939; rs11913898; rs7284662; rs1005529; rs17563060; rs11570718; rs11570665; rs9610908; rs132971; rs16998755; rs11089865; rs132965; rs11570611; rs11570716; rs11570733; rs11570749; rs11570624; rs4821749; rs5756946; rs9610907; rs1005528; rs11570663; rs11570669; rs11089863; rs5750541; rs11570659; rs132945; rs11570640; rs2281108; rs6001017; rs2284064; rs11570719; rs11570634; rs11570653; rs11570620; rs4821748; rs11570702; rs11570711; rs6001032; rs132950; rs11089870; rs4821753; rs4820321; rs4821752; rs5995543; rs5750556; rs11570590; rs11570589; rs12157473; rs11570646; rs11570607; rs12627857; rs8142389; rs11570604; rs8137578; rs133020; rs36014862; rs35804966; rs2413504; rs34718565; rs133027; rs34139192; rs34365126; rs132990; rs735336; rs133000; rs34190594; rs35260453; rs133025; rs28565947; rs35526737; rs28653361; rs28718653; rs11570597; rs28421906; rs34856995; rs133005; rs11570600; rs2142838; rs133028; rs34809384; rs35231946; rs9607514; rs133004; rs35950199; rs34292639; rs133026; rs133002; rs28428653; rs35530438; rs133011; rs11471646; rs11570697; rs11570673; rs11570618; rs7291586; rs35501048; rs11570699; rs8142930; rs9610905; rs11570689; rs28719740; rs11570626; rs34701842; rs11570694; rs35313235; rs11570757; rs11570656; rs8140579; rs5756920; rs11570637; rs12329956; rs8140454; rs34536395; rs10543970; rs132943; rs11570725; rs132962; rs5995540; rs132956; rs34174459; rs9607512; rs28460110; rs11570616; rs132967; rs11704969; rs11570685; rs11570615; rs132980; rs12162857; rs12162828; rs8141149; rs35709752; rs12165507; rs2235343; rs12167913; rs11570621; rs11441204; rs9610906; rs34612391; rs6001013; rs11570729; rs11570623; rs11570691; rs9610909; rs11570706; rs35883426; rs11570756; rs11570631; rs11570664; rs28695983; rs11570610; rs5845373; rs11570741; rs11570654; rs132937; rs132949; rs11570712; rs5756927; rs10709435; rs11570743; rs11570703; rs9610904; rs34951630; rs6001016; rs34848813; rs11570758; rs35736012; rs11570693; rs34164997; rs11570628; rs11570704; rs12169611; rs11570619; rs5750554; rs11570652; rs11570642; rs34471882; rs5845371; rs2281107; rs7511015; rs132948; rs5756925; rs132935; rs35449261; rs11570661; rs34143772; rs34550422; rs9619722; rs11570612; rs132958; rs11570648; rs9622739; rs11570671; rs35897756; rs11570650; rs5845374; rs11570752; rs4521147; rs11570695; rs11570686; rs34896234; rs132961; rs9622729; rs11570644; rs34944600; rs11570688; rs11570617; rs35195613; rs11570698; rs11913581; rs132981; rs132951; rs12168078; rs11570633; rs11570754; rs5995541; rs11570731; rs132983; rs35205726; rs35928089; rs132942; rs28366733; rs35103228; rs41274545; rs11570738; rs132938; rs10427716; rs11308495; rs35120028; rs132968; rs34478021; rs11570759; rs5845372; rs35606878; rs11570625; rs35795447; rs9607513; rs9622727; rs35440920; rs35948405; rs11570742; rs5995539; rs132947; rs132936; rs36103241; rs5750551; rs11570632; rs35214564; rs35737378; rs132955; rs11570723; rs4610161; rs9622731; rs12165464; rs11570705; rs9622745; rs11570735; rs11570760; rs12484261; rs11570643; rs11570675; rs5756924; rs13054568; rs35788613; rs132957; rs132940; rs34184783; rs5995537; rs5756919; rs11570613; rs11570622; rs11570692; rs36110979; rs11442770; rs11570740; rs132963; rs34379826; rs35337783; rs11570708; rs34566636; rs7290683; rs11570629; rs11570755; rs11570592; rs11570591; rs11570594; rs12167142; rs12167111; rs35918994; rs2142729; rs11570593; rs13054001; rs11570595; rs5756950; rs11570596; rs34482513; rs34112430; rs11089861; rs11570773; rs12484232; rs13055413; rs34184838; rs4296527; rs4820313; rs4821737; rs4821738; rs4821754; rs5756914; rs5756916; rs5995544; rs6001007; rs6001008; rs6001009; rs8140036; rs9306324; rs9622726

# Metabolic_Enzyme_2_General_References:
9417066; 10092647; 10336645; 10591208

# Metabolic_Enzyme_2_References:
10438167; 9135530

# Metabolic_Enzyme_3_ID:
8371

# Metabolic_Enzyme_3_Name:
Multidrug resistance protein 1

# Metabolic_Enzyme_3_Synonyms:
ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD243 antigen

# Metabolic_Enzyme_3_Gene_Name:
ABCB1

# Metabolic_Enzyme_3_Protein_Sequence:
>Multidrug resistance protein 1
MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAII
HGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSG
IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS
KINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFT
DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG
AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARG
AAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSG
QTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLF
ATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA
IARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAG
FDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRS
SLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAII
NGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKA
GEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNI
ANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEA
IENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFG
AYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDS
YSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVV
QLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVV
SQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLD
EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL
LAQKGIYFSMVSVQAGTKRQ

# Metabolic_Enzyme_3_Number_of_Residues:
1280

# Metabolic_Enzyme_3_Molecular_Weight:
141464

# Metabolic_Enzyme_3_Theoretical_pI:
9.44

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  ATPase activity
Function:  hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Function:  ATPase activity, coupled to transmembrane movement of substances
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Metabolic_Enzyme_3_General_Function:
Defense mechanisms 

# Metabolic_Enzyme_3_Specific_Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells

# Metabolic_Enzyme_3_Pathway:
Not Available

# Metabolic_Enzyme_3_Reaction:
ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00664:ABC_membrane;
PF00005:ABC_tran

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
52-72
120-140
189-209
216-236
297-317
326-346
711-731
757-777
833-853
854-874
937-957
974-994

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.6.3.44

# Metabolic_Enzyme_3_GenBank_ID_Protein:
307180

# Metabolic_Enzyme_3_SwissProt_ID:
MDR1_HUMAN (P08183)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ABCB1

# Metabolic_Enzyme_3_Geneatlas_id:
ABCB1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:40

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Membrane; multi-pass membrane protein

# Metabolic_Enzyme_3_Gene_Sequence:
>3843 bp
ATGGATCTTGAAGGGGACCGCAATGGAGGAGCAAAGAAGAAGAACTTTTTTAAACTGAAC
AATAAAAGTGAAAAAGATAAGAAGGAAAAGAAACCAACTGTCAGTGTATTTTCAATGTTT
CGCTATTCAAATTGGCTTGACAAGTTGTATATGGTGGTGGGAACTTTGGCTGCCATCATC
CATGGGGCTGGACTTCCTCTCATGATGCTGGTGTTTGGAGAAATGACAGATATCTTTGCA
AATGCAGGAAATTTAGAAGATCTGATGTCAAACATCACTAATAGAAGTGATATCAATGAT
ACAGGGTTCTTCATGAATCTGGAGGAAGACATGACCAGGTATGCCTATTATTACAGTGGA
ATTGGTGCTGGGGTGCTGGTTGCTGCTTACATTCAGGTTTCATTTTGGTGCCTGGCAGCT
GGAAGACAAATACACAAAATTAGAAAACAGTTTTTTCATGCTATAATGCGACAGGAGATA
GGCTGGTTTGATGTGCACGATGTTGGGGAGCTTAACACCCGACTTACAGATGATGTCTCT
AAGATTAATGAAGTTATTGGTGACAAAATTGGAATGTTCTTTCAGTCAATGGCAACATTT
TTCACTGGGTTTATAGTAGGATTTACACGTGGTTGGAAGCTAACCCTTGTGATTTTGGCC
ATCAGTCCTGTTCTTGGACTGTCAGCTGCTGTCTGGGCAAAGATACTATCTTCATTTACT
GATAAAGAACTCTTAGCGTATGCAAAAGCTGGAGCAGTAGCTGAAGAGGTCTTGGCAGCA
ATTAGAACTGTGATTGCATTTGGAGGACAAAAGAAAGAACTTGAAAGGTACAACAAAAAT
TTAGAAGAAGCTAAAAGAATTGGGATAAAGAAAGCTATTACAGCCAATATTTCTATAGGT
GCTGCTTTCCTGCTGATCTATGCATCTTATGCTCTGGCCTTCTGGTATGGGACCACCTTG
GTCCTCTCAGGGGAATATTCTATTGGACAAGTACTCACTGTATTCTTTTCTGTATTAATT
GGGGCTTTTAGTGTTGGACAGGCATCTCCAAGCATTGAAGCATTTGCAAATGCAAGAGGA
GCAGCTTATGAAATCTTCAAGATAATTGATAATAAGCCAAGTATTGACAGCTATTCGAAG
AGTGGGCACAAACCAGATAATATTAAGGGAAATTTGGAATTCAGAAATGTTCACTTCAGT
TACCCATCTCGAAAAGAAGTTAAGATCTTGAAGGGCCTGAACCTGAAGGTGCAGAGTGGG
CAGACGGTGGCCCTGGTTGGAAACAGTGGCTGTGGGAAGAGCACAACAGTCCAGCTGATG
CAGAGGCTCTATGACCCCACAGAGGGGATGGTCAGTGTTGATGGACAGGATATTAGGACC
ATAAATGTAAGGTTTCTACGGGAAATCATTGGTGTGGTGAGTCAGGAACCTGTATTGTTT
GCCACCACGATAGCTGAAAACATTCGCTATGGCCGTGAAAATGTCACCATGGATGAGATT
GAGAAAGCTGTCAAGGAAGCCAATGCCTATGACTTTATCATGAAACTGCCTCATAAATTT
GACACCCTGGTTGGAGAGAGAGGGGCCCAGTTGAGTGGTGGGCAGAAGCAGAGGATCGCC
ATTGCACGTGCCCTGGTTCGCAACCCCAAGATCCTCCTGCTGGATGAGGCCACGTCAGCC
TTGGACACAGAAAGCGAAGCAGTGGTTCAGGTGGCTCTGGATAAGGCCAGAAAAGGTCGG
ACCACCATTGTGATAGCTCATCGTTTGTCTACAGTTCGTAATGCTGACGTCATCGCTGGT
TTCGATGATGGAGTCATTGTGGAGAAAGGAAATCATGATGAACTCATGAAAGAGAAAGGC
ATTTACTTCAAACTTGTCACAATGCAGACAGCAGGAAATGAAGTTGAATTAGAAAATGCA
GCTGATGAATCCAAAAGTGAAATTGATGCCTTGGAAATGTCTTCAAATGATTCAAGATCC
AGTCTAATAAGAAAAAGATCAACTCGTAGGAGTGTCCGTGGATCACAAGCCCAAGACAGA
AAGCTTAGTACCAAAGAGGCTCTGGATGAAAGTATACCTCCAGTTTCCTTTTGGAGGATT
ATGAAGCTAAATTTAACTGAATGGCCTTATTTTGTTGTTGGTGTATTTTGTGCCATTATA
AATGGAGGCCTGCAACCAGCATTTGCAATAATATTTTCAAAGATTATAGGGGTTTTTACA
AGAATTGATGATCCTGAAACAAAACGACAGAATAGTAACTTGTTTTCACTATTGTTTCTA
GCCCTTGGAATTATTTCTTTTATTACATTTTTCCTTCAGGGTTTCACATTTGGCAAAGCT
GGAGAGATCCTCACCAAGCGGCTCCGATACATGGTTTTCCGATCCATGCTCAGACAGGAT
GTGAGTTGGTTTGATGACCCTAAAAACACCACTGGAGCATTGACTACCAGGCTCGCCAAT
GATGCTGCTCAAGTTAAAGGGGCTATAGGTTCCAGGCTTGCTGTAATTACCCAGAATATA
GCAAATCTTGGGACAGGAATAATTATATCCTTCATCTATGGTTGGCAACTAACACTGTTA
CTCTTAGCAATTGTACCCATCATTGCAATAGCAGGAGTTGTTGAAATGAAAATGTTGTCT
GGACAAGCACTGAAAGATAAGAAAGAACTAGAAGGTGCTGGGAAGATCGCTACTGAAGCA
ATAGAAAACTTCCGAACCGTTGTTTCTTTGACTCAGGAGCAGAAGTTTGAACATATGTAT
GCTCAGAGTTTGCAGGTACCATACAGAAACTCTTTGAGGAAAGCACACATCTTTGGAATT
ACATTTTCCTTCACCCAGGCAATGATGTATTTTTCCTATGCTGGATGTTTCCGGTTTGGA
GCCTACTTGGTGGCACATAAACTCATGAGCTTTGAGGATGTTCTGTTAGTATTTTCAGCT
GTTGTCTTTGGTGCCATGGCCGTGGGGCAAGTCAGTTCATTTGCTCCTGACTATGCCAAA
GCCAAAATATCAGCAGCCCACATCATCATGATCATTGAAAAAACCCCTTTGATTGACAGC
TACAGCACGGAAGGCCTAATGCCGAACACATTGGAAGGAAATGTCACATTTGGTGAAGTT
GTATTCAACTATCCCACCCGACCGGACATCCCAGTGCTTCAGGGACTGAGCCTGGAGGTG
AAGAAGGGCCAGACGCTGGCTCTGGTGGGCAGCAGTGGCTGTGGGAAGAGCACAGTGGTC
CAGCTCCTGGAGCGGTTCTACGACCCCTTGGCAGGGAAAGTGCTGCTTGATGGCAAAGAA
ATAAAGCGACTGAATGTTCAGTGGCTCCGAGCACACCTGGGCATCGTGTCCCAGGAGCCC
ATCCTGTTTGACTGCAGCATTGCTGAGAACATTGCCTATGGAGACAACAGCCGGGTGGTG
TCACAGGAAGAGATCGTGAGGGCAGCAAAGGAGGCCAACATACATGCCTTCATCGAGTCA
CTGCCTAATAAATATAGCACTAAAGTAGGAGACAAAGGAACTCAGCTCTCTGGTGGCCAG
AAACAACGCATTGCCATAGCTCGTGCCCTTGTTAGACAGCCTCATATTTTGCTTTTGGAT
GAAGCCACGTCAGCTCTGGATACAGAAAGTGAAAAGGTTGTCCAAGAAGCCCTGGACAAA
GCCAGAGAAGGCCGCACCTGCATTGTGATTGCTCACCGCCTGTCCACCATCCAGAATGCA
GACTTAATAGTGGTGTTTCAGAATGGCAGAGTCAAGGAGCATGGCACGCATCAGCAGCTG
CTGGCACAGAAAGGCATCTATTTTTCAATGGTCAGTGTCCAGGCTGGAACAAAGCGCCAG
TGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M14758

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_3_Locus:
7q21.1

# Metabolic_Enzyme_3_SNPs:
rs2032582; rs2229107; rs2229109; rs9282565; rs9282564; rs1202183; rs28364274; rs28401798; rs1045642; rs1128503; rs34748655; rs9282563; rs2235051; rs2235012; rs2188524; rs4728709; rs2214102; rs3213619; rs28381802; rs4148730; rs17149824; rs12720464; rs28364275; rs28381800; rs17328260; rs12536690; rs17328288; rs4148731; rs1978095; rs28381792; rs28381776; rs28381783; rs28381778; rs17328198; rs28381789; rs28381774; rs28364277; rs13233308; rs28381799; rs28381777; rs17149810; rs28381801; rs28364278; rs28381790; rs28381796; rs28381780; rs28381772; rs28381795; rs12668917; rs28381797; rs17064; rs28381787; rs28381781; rs28364279; rs28381771; rs28746504; rs28381779; rs28381773; rs3214119; rs3842; rs28381782; rs12671453; rs28381794; rs11395081; rs28381785; rs2235052; rs4148732; rs28381791; rs28381775; rs17149813; rs28381784; rs2091766; rs1202168; rs1202172; rs1202186; rs1002205; rs1922240; rs1882478; rs1202179; rs1202181; rs2520464; rs2235046; rs2235013; rs1882479; rs1202185; rs4148738; rs2373587; rs4148744; rs6961419; rs2235019; rs1202171; rs7779562; rs10236274; rs10244266; rs4148737; rs4148736; rs10264990; rs3789244; rs1989830; rs4148750; rs10274587; rs956825; rs7787082; rs4148751; rs12539098; rs10268314; rs6952752; rs1186745; rs7787569; rs7795817; rs2235049; rs1202184; rs10248420; rs1202170; rs2235067; rs1202167; rs2141849; rs1202169; rs6949448; rs1202166; rs6961882; rs4148740; rs1202182; rs4437575; rs1211433; rs1882477; rs4148745; rs10225464; rs7802773; rs2235074; rs10276036; rs1922242; rs12704364; rs11975994; rs2235048; rs6961665; rs1922243; rs4148743; rs6980101; rs2235035; rs4148735; rs10260862; rs4148733; rs6950978; rs1016794; rs1202178; rs1202174; rs2032584; rs10256836; rs955000; rs2373588; rs11983225; rs12720066; rs10274441; rs6946379; rs12535512; rs11763872; rs2235033; rs6961417; rs12673269; rs10274623; rs12668877; rs12154941; rs10263741; rs10244116; rs1002204; rs1922241; rs10280101; rs12720067; rs17149754; rs2888599; rs2214104; rs10259849; rs10276603; rs2235018; rs4148742; rs4148739; rs2235026; rs28381837; rs10234411; rs10808072; rs1202175; rs10240953; rs11760837; rs2214103; rs4728702; rs1922244; rs17149738; rs1016793; rs11772987; rs6979885; rs3789243; rs2373586; rs2032583; rs10246696; rs11979702; rs1989831; rs2373589; rs2235027; rs2235040; rs17149792; rs6959435; rs6948766; rs1202176; rs17327624; rs4148749; rs868755; rs10808071; rs17327442; rs4728700; rs4728701; rs6978925; rs1858923; rs17131983; rs17149772; rs2235066; rs3789246; rs28381958; rs28401770; rs1211152; rs28381878; rs28381872; rs4728705; rs2235016; rs28381965; rs2032585; rs4148747; rs28401778; rs28381857; rs2235043; rs28746509; rs7787424; rs28381920; rs28381895; rs2235020; rs2235065; rs28381845; rs13226726; rs28381826; rs28381928; rs16706; rs28381905; rs17149699; rs28401802; rs2235014; rs28381827; rs2235028; rs28381957; rs2235042; rs28401784; rs28381929; rs7804127; rs28401815; rs28381809; rs28401779; rs2235070; rs28381931; rs28381839; rs4148734; rs28381877; rs2235015; rs28381884; rs28381939; rs28381919; rs6971264; rs28381866; rs2235034; rs1202177; rs12334183; rs28401776; rs2235045; rs28381868; rs28381946; rs2235023; rs10280623; rs28381831; rs28401816; rs1186746; rs28381855; rs7804128; rs3028303; rs7787421; rs4728699; rs28401819; rs28381892; rs28401796; rs2214105; rs28381963; rs28381944; rs28381908; rs28381885; rs7802257; rs28381816; rs28401809; rs28381807; rs2235069; rs28401777; rs28381820; rs28381817; rs28381832; rs2373585; rs16885829; rs28381886; rs2235075; rs11304553; rs28401801; rs28381962; rs28381875; rs28381907; rs28381850; rs28401782; rs4148746; rs28381887; rs1186744; rs16885833; rs28364273; rs1024409; rs11769518; rs11761122; rs28381861; rs28381869; rs28381880; rs28381853; rs28381924; rs28746505; rs11972405; rs28401805; rs28401799; rs28381940; rs28746510; rs2235021; rs2235047; rs28381838; rs28381842; rs28381961; rs28381848; rs10249333; rs2032588; rs28381876; rs28381916; rs2235024; rs2235064; rs1989829; rs28401788; rs28381909; rs4728707; rs13239201; rs1211151; rs28381947; rs4728706; rs28401806; rs28381960; rs28381903; rs28401814; rs28381934; rs12704363; rs2188526; rs2235063; rs28401820; rs13229143; rs28381852; rs10225473; rs28381863; rs17327942; rs28381873; rs28364271; rs6970380; rs28381825; rs28381847; rs2235030; rs28381840; rs28381819; rs28381814; rs2235050; rs28381862; rs2188525; rs28401817; rs28381917; rs28401812; rs28401797; rs17149790; rs28381910; rs2235041; rs28381911; rs28401792; rs1209054; rs12154319; rs28381883; rs2235029; rs28364270; rs28401773; rs28381856; rs1202180; rs17327747; rs2032586; rs13237132; rs1202173; rs28401781; rs28381922; rs28381950; rs28381841; rs1055302; rs12539997; rs11984161; rs28381914; rs41309225; rs2707944; rs28381804; rs28381902; rs41315618; rs2032581; rs28381967; rs2235039; rs41305517; rs41316450; rs41309231; rs2235036; rs1128501; rs41309228; rs28381867; rs41304191; rs1128502; rs41311775; rs1128500; rs2235044; rs28381915; rs2707943; rs2235022; rs28381966; rs9332385; rs6977171; rs28381788; rs5014440; rs35770463; rs35644241; rs35267921; rs41296639; rs35012650; rs34081055; rs28655259; rs11294617; rs28364281; rs35855743; rs35453635; rs35447943; rs35141338; rs28381798; rs13242633; rs35260049; rs1468149; rs35477648; rs35998786; rs11440098; rs7794477; rs41297363; rs5885591; rs4604363; rs35132449; rs34962462; rs35268090; rs11342943; rs10275895; rs34208689; rs5014439; rs3926353; rs28381786; rs28381793; rs1966313; rs28364280; rs3926352; rs35998484; rs28381803; rs6952798; rs11440100; rs10275536; rs41297348; rs10600037; rs41278761; rs28381815; rs35600470; rs2706100; rs2235025; rs35471539; rs6971424; rs10252821; rs41297360; rs28381906; rs4728697; rs35757402; rs13230066; rs28401785; rs34947426; rs2706098; rs28381951; rs35227154; rs5014436; rs10600040; rs28381921; rs34445246; rs28381836; rs35818141; rs2235072; rs41308867; rs34775842; rs34289914; rs34776171; rs41297351; rs6980354; rs28381871; rs17149783; rs28401790; rs28381890; rs34445458; rs34628915; rs4148752; rs35639555; rs34885273; rs34598903; rs28381899; rs28549812; rs35711803; rs41316453; rs36015329; rs36218788; rs28401807; rs35335128; rs28381844; rs28381854; rs28381927; rs41309234; rs28381833; rs28401795; rs36097582; rs35513721; rs36008665; rs28381900; rs28381870; rs2373590; rs28746508; rs28381964; rs4148741; rs28381828; rs28381829; rs34298931; rs35280822; rs1922238; rs28381834; rs28381953; rs28401793; rs11440096; rs7457890; rs41309222; rs6952359; rs28381952; rs34609577; rs28381913; rs28401786; rs28381808; rs10273964; rs28381851; rs35981891; rs33959732; rs28381941; rs5014438; rs10237477; rs28381888; rs2235062; rs28381897; rs10532925; rs28381901; rs11974399; rs12720440; rs28381821; rs28746507; rs34127337; rs28381954; rs35440979; rs11768388; rs28681479; rs28401794; rs35766168; rs28381945; rs28381932; rs5014437; rs28381959; rs10244525; rs28381943; rs5885590; rs28401813; rs2706099; rs5885589; rs6973406; rs28381935; rs28381904; rs41297354; rs41297345; rs41316456; rs12720069; rs28401803; rs28381818; rs13245606; rs28381948; rs28746506; rs28381898; rs35334908; rs35070592; rs28381891; rs28381810; rs34923788; rs34332398; rs41296636; rs28381933; rs10600038; rs28381806; rs34657813; rs28401774; rs41296633; rs28381822; rs35498006; rs35572298; rs41274218; rs2235017; rs2235073; rs28401775; rs28381811; rs2235038; rs28381860; rs5885588; rs28381874; rs28381955; rs11322711; rs34291906; rs28381936; rs28381894; rs10661738; rs28371078; rs28401821; rs34614047; rs11348505; rs28381881; rs35522790; rs41296630; rs6150207; rs28381823; rs34986820; rs28381843; rs1212957; rs28401804; rs2235032; rs10600039; rs28401811; rs1922237; rs28401768; rs28381805; rs28364268; rs28401783; rs34532729; rs28401787; rs36119114; rs28401791; rs41304188; rs2235037; rs4727148; rs28381893; rs35635932; rs28401772; rs28381812; rs35238388; rs5885587; rs34517102; rs28381882; rs28381956; rs2373591; rs28401808; rs28381835; rs36218789; rs28381858; rs35259034; rs28381937; rs35687466; rs34513210; rs28381865; rs28401780; rs28381923; rs34325451; rs1882480; rs36125978; rs41278758; rs41309219; rs28401800; rs28381830; rs10240853; rs28381824; rs12720070; rs10274054; rs28718458; rs11771798; rs28381925; rs2235071; rs28381912; rs35881718; rs7809208; rs41297357; rs28401769; rs41304194; rs28381864; rs41296642; rs28401771; rs41315621; rs28381879; rs28381942; rs28381859; rs28364272; rs28381930; rs28381918; rs28381949; rs28381849; rs2706101; rs28381926; rs10713802; rs28401789; rs34766508; rs28381889; rs28364269; rs28381938; rs28381813; rs1202165; rs35820221; rs28401818; rs28381846; rs35396007; rs35583835; rs41312547; rs34127828; rs28381896; rs1055304; rs1055305; rs36074739; rs1015415; rs10231033; rs10232449; rs10233247; rs10246878; rs10254392; rs10261685; rs10264856; rs10267099; rs10275831; rs10276499; rs10278483; rs10486996; rs11973812; rs11975403; rs11983274; rs11983624; rs11984283; rs12538707; rs12539395; rs12540931; rs12670317; rs12672720; rs12704366; rs13221839; rs13231229; rs17149840; rs17149850; rs17149854; rs17149864; rs17149866; rs17209837; rs17250003; rs2028026; rs2157926; rs2157928; rs2157929; rs2188528; rs2188530; rs34398291; rs34767983; rs34800935; rs35633772; rs3747802; rs4148727; rs4148728; rs4263684; rs6465118; rs6951067; rs6952194; rs6957599; rs6963426; rs6968274; rs6969155; rs7455204; rs7786524; rs7790722; rs7790798; rs7796247; rs7799907; rs7802783; rs7810499; rs916715; rs9641019; rs998671

# Metabolic_Enzyme_3_General_References:
2876781; 1967175; 9038218; 12853948; 1972623; 2568832; 11258197; 2897240; 9473242; 10790226; 10716719; 11240981; 11829140

# Metabolic_Enzyme_3_References:
12642476

# Metabolic_Enzyme_4_ID:
7940

# Metabolic_Enzyme_4_Name:
Bile salt-activated lipase precursor

# Metabolic_Enzyme_4_Synonyms:
BAL; Bile salt-stimulated lipase; BSSL; Carboxyl ester lipase; Sterol esterase; Cholesterol esterase; Pancreatic lysophospholipase

# Metabolic_Enzyme_4_Gene_Name:
CEL

# Metabolic_Enzyme_4_Protein_Sequence:
>Bile saltactivated lipase precursor
MGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTK
ALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPV
MIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPG
NYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQS
GVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAGLEYP
MLHYVGFVPVIDGDFIPADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVT
EEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIA
LAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTV
SKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLR
YWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSG
APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP
PTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDS
EAAPVPPTDDSKEAQMPAVIRF

# Metabolic_Enzyme_4_Number_of_Residues:
742

# Metabolic_Enzyme_4_Molecular_Weight:
78346

# Metabolic_Enzyme_4_Theoretical_pI:
5.01

# Metabolic_Enzyme_4_GO_Classification:
Not Available

# Metabolic_Enzyme_4_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides

# Metabolic_Enzyme_4_Pathway:
map00120  Bile acid biosynthesis

# Metabolic_Enzyme_4_Reaction:
A steryl ester + H2O = a sterol + a fatty acid

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00135:COesterase

# Metabolic_Enzyme_4_Signals:
1-20

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.1.1.3;EC 3.1.1.13

# Metabolic_Enzyme_4_GenBank_ID_Protein:
29501

# Metabolic_Enzyme_4_SwissProt_ID:
CEL_HUMAN (P19835)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CEL

# Metabolic_Enzyme_4_Geneatlas_id:
CEL

# Metabolic_Enzyme_4_hgnc_id:
HGNC:1848

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>2238 bp
ATGCTCACCATGGGGCGCCTGCAACTGGTTGTGTTGGGCCTCACCTGCTGCTGGGCAGTG
GCGAGTGCCGCGAAGCTGGGCGCCGTGTACACAGAAGGTGGGTTCGTGGAAGGCGTCAAT
AAGAAGCTCGGCCTCCTGGGTGACTCTGTGGACATCTTCAAGGGCATCCCCTTCGCAGCT
CCCACCAAGGCCCTGGAAAATCCTCAGCCACATCCTGGCTGGCAAGGGACCCTGAAGGCC
AAGAACTTCAAGAAGAGATGCCTGCAGGCCACCATCACCCAGGACAGCACCTACGGGGAT
GAAGACTGCCTGTACCTCAACATTTGGGTGCCCCAGGGCAGGAAGCAAGTCTCCCGGGAC
CTGCCCGTTATGATCTGGATCTATGGAGGCGCCTTCCTCATGGGGTCCGGCCATGGGGCC
AACTTCCTCAACAACTACCTGTATGACGGCGAGGAGATCGCCACACGCGGAAACGTCATC
GTGGTCACCTTCAACTACCGTGTCGGCCCCCTTGGGTTCCTCAGCACTGGGGACGCCAAT
CTGCCAGGTAACTATGGCCTTCGGGATCAGCACATGGCCATTGCTTGGGTGAAGAGGAAT
ATCGCGGCCTTCGGGGGGGACCCCAACAACATCACGCTCTTCGGGGAGTCTGCTGGAGGT
GCCAGCGTCTCTCTGCAGACCCTCTCCCCCTACAACAAGGGCCTCATCCGGCGAGCCATC
AGCCAGAGCGGCGTGGCCCTGAGTCCCTGGGTCATCCAGAAAAACCCACTCTTCTGGGCC
AAAAAGGTGGCTGAGAAGGTGGGTTGCCCTGTGGGTGATGCCGCCAGGATGGCCCAGTGT
CTGAAGGTTACTGATCCCCGAGCCCTGACGCTGGCCTATAAGGTGCCGCTGGCAGGCCTG
GAGTACCCCATGCTGCACTATGTGGGCTTCGTCCCTGTCATTGATGGAGACTTCATCCCC
GCTGACCCGATCAACCTGTACGCCAACGCCGCCGACATCGACTATATAGCAGGCACCAAC
AACATGGACGGCCACATCTTCGCCAGCATCGACATGCCTGCCATCAACAAGGGCAACAAG
AAAGTCACGGAGGAGGACTTCTACAAGCTGGTCAGTGAGTTCACAATCACCAAGGGGCTC
AGAGGCGCCAAGACGACCTTTGATGTCTACACCGAGTCCTGGGCCCAGGACCCATCCCAG
GAGAATAAGAAGAAGACTGTGGTGGACTTTGAGACCGATGTCCTCTTCCTGGTGCCCACC
GAGATTGCCCTAGCCCAGCACAGAGCCAATGCCAAGAGTGCCAAGACCTACGCCTACCTG
TTTTCCCATCCCTCTCGGATGCCCGTCTACCCCAAATGGGTGGGGGCCGACCATGCAGAT
GACATTCAGTACGTTTTCGGGAAGCCCTTCGCCACCCCCACGGGCTACCGGCCCCAAGAC
AGGACAGTCTCTAAGGCCATGATCGCCTACTGGACCAACTTTGCCAAAACAGGGGACCCC
AACATGGGCGACTCGGCTGTGCCCACACACTGGGAACCCTACACTACGGAAAACAGCGGC
TACCTGGAGATCACCAAGAAGATGGGCAGCAGCTCCATGAAGCGGAGCCTGAGAACCAAC
TTCCTGCGCTACTGGACCCTCACCTATCTGGCGCTGCCCACAGTGACCGACCAGGAGGCC
ACCCCTGTGCCCCCCACAGGGGACTCCGAGGCCACTCCCGTGCCCCCCACGGGTGACTCC
GAGACCGCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCCCCCGTGCCGCCCACGGGT
GACTCCGGGGCCCCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCCCCCGTGCCGCCC
ACGGGTGACTCCGGGGCCCCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCCCCCGTG
CCGCCCACGGGTGACTCCGGGGCCCCCCCCGTGCCGCCCACGGGTGACTCCGGCGCCCCC
CCCGTGCCGCCCACGGGTGACGCCGGGCCCCCCCCCGTGCCGCCCACGGGTGACTCCGGC
GCCCCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCCCCCGTGACCCCCACGGGTGAC
TCCGAGACCGCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCCCCTGTGCCCCCCACG
GGTGACTCTGAGGCTGCCCCTGTGCCCCCCACAGATGACTCCAAGGAAGCTCAGATGCCT
GCAGTCATTAGGTTTTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
X54457

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_4_Locus:
9q34.3

# Metabolic_Enzyme_4_SNPs:
rs2013751; rs592267; rs8193020; rs657740; rs668809; rs658107; rs657747; rs674908; rs1734945; rs9328542; rs35169970; rs2480920; rs34800980; rs2480922; rs35939167; rs490954; rs657704; rs2480921; rs11552537; rs13287310; rs13283110; rs2480923; rs488087; rs657617; rs35171271; rs2257704; rs598333; rs8193023; rs640509; rs2013695; rs1318508; rs2855061; rs11243990; rs12341761; rs915953; rs35064121; rs2855063; rs2855064; rs2855057; rs2773809; rs12351505; rs11243989; rs2855059; rs36126424; rs11355299; rs8193019; rs7851444; rs644166; rs2855062; rs915950; rs34365056; rs2855056; rs687763; rs34519053; rs34646804; rs11243991; rs2855058; rs640507; rs2855055; rs12344494; rs2855049; rs600825; rs2855066; rs11243988; rs470512; rs2855060; rs2905087; rs2855053; rs12001261; rs2855050; rs12001694; rs674510; rs642440; rs2855054; rs2855052; rs13296252; rs2001000; rs34064957; rs10121942; rs1047780; rs11792806; rs12236821; rs17150138; rs2073821; rs2283134; rs28758507; rs35181097; rs491904; rs509064; rs526855; rs534629; rs563864; rs586977; rs590504; rs607809; rs637435; rs640720; rs645736; rs645841; rs6597598; rs685959; rs7021286; rs7044003; rs7324; rs7852868; rs7863758; rs8193017

# Metabolic_Enzyme_4_General_References:
1698625; 2265692; 1988041; 1639390; 7578248; 1991511; 7654718; 10024660; 11045623

# Metabolic_Enzyme_4_References:
8639615; 9366275

# Metabolic_Enzyme_5_ID:
8348

# Metabolic_Enzyme_5_Name:
Enteropeptidase precursor

# Metabolic_Enzyme_5_Synonyms:
Enterokinase; Serine protease 7[Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain]

# Metabolic_Enzyme_5_Gene_Name:
PRSS7

# Metabolic_Enzyme_5_Protein_Sequence:
>Enteropeptidase precursor
MGSKRGISSRHHSLSSYEIMFAALFAILVVLCAGLIAVSCLTIKESQRGAALGQSHEARA
TFKITSGVTYNPNLQDKLSVDFKVLAFDLQQMIDEIFLSSNLKNEYKNSRVLQFENGSII
VVFDLFFAQWVSDQNVKEELIQGLEANKSSQLVTFHIDLNSVDILDKLTTTSHLATPGNV
SIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQA
THYPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYYTDILDIYEGVGSSKILRASIWETN
PGTIRIFSNQVTATFLIESDESDYVGFNATYTAFNSSELNNYEKINCNFEDGFCFWVQDL
NDDNEWERIQGSTFSPFTGPNFDHTFGNASGFYISTPTGPGGRQERVGLLSLPLDPTLEP
ACLSFWYHMYGENVHKLSINISNDQNMEKTVFQKEGNYGDNWNYGQVTLNETVKFKVAFN
AFKNKILSDIALDDISLTYGICNGSLYPEPTLVPTPPPELPTDCGGPFELWEPNTTFSST
NFPNSYPNLAFCVWILNAQKGKNIQLHFQEFDLENINDVVEIRDGEEADSLLLAVYTGPG
PVKDVFSTTNRMTVLLITNDVLARGGFKANFTTGYHLGIPEPCKADHFQCKNGECVPLVN
LCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTACAENWTTQISNDVCQLLG
LGSGNSSKPIFSTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQD
ITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAI
LGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEE
NQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICAGYE
EGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFLH

# Metabolic_Enzyme_5_Number_of_Residues:
1019

# Metabolic_Enzyme_5_Molecular_Weight:
112925

# Metabolic_Enzyme_5_Theoretical_pI:
4.67

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  scavenger receptor activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
Function:  enteropeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases

# Metabolic_Enzyme_5_Pathway:
Not Available

# Metabolic_Enzyme_5_Reaction:
Activation of trypsinogen by selective cleavage of Lys6-|-Ile bond

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00431:CUB;
PF00057:Ldl_recept_a;
PF00629:MAM;
PF01390:SEA;
PF00530:SRCR;
PF00089:Trypsin

# Metabolic_Enzyme_5_Signals:
1-40

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.4.21.9

# Metabolic_Enzyme_5_GenBank_ID_Protein:
746413

# Metabolic_Enzyme_5_SwissProt_ID:
ENTK_HUMAN (P98073)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
PRSS7

# Metabolic_Enzyme_5_Geneatlas_id:
PRSS7

# Metabolic_Enzyme_5_hgnc_id:
HGNC:9490

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Membrane; single-pass type II membrane protein (Probable)

# Metabolic_Enzyme_5_Gene_Sequence:
>3060 bp
ATGGGGTCGAAAAGAGGCATATCTTCTAGGCATCATTCTCTCAGCTCCTATGAAATCATG
TTTGCAGCTCTCTTTGCCATATTGGTAGTGCTCTGTGCTGGATTAATTGCAGTATCCTGC
CTGACAATCAAGGAATCCCAACGAGGTGCAGCACTTGGACAGAGTCATGAAGCCAGAGCG
ACATTTAAAATAACATCCGGAGTTACATATAATCCTAATTTGCAAGACAAACTCTCAGTG
GATTTCAAAGTTCTTGCTTTTGACCTTCAGCAAATGATAGATGAGATCTTTCTATCAAGC
AATCTGAAGAATGAATATAAGAACTCAAGAGTTTTACAATTTGAAAATGGCAGCATTATA
GTCGTATTTGACCTTTTCTTTGCCCAGTGGGTGTCAGATCAAAATGTAAAAGAAGAACTG
ATTCAAGGCCTTGAAGCAAATAAATCCAGCCAACTGGTCACTTTCCATATTGATTTGAAC
AGCGTTGATATCCTAGACAAGCTAACAACCACCAGTCATCTGGCAACTCCAGGAAATGTC
TCAATAGAGTGCCTGCCTGGTTCAAGTCCTTGTACTGATGCTCTAACGTGTATAAAAGCT
GATTTATTTTGTGATGGAGAAGTAAACTGTCCAGATGGTTCTGACGAAGACAATAAAATG
TGTGCCACAGTTTGTGATGGAAGATTTTTGTTAACTGGATCATCTGGGTCTTTCCAGGCT
ACTCATTATCCAAAACCTTCTGAAACAAGTGTTGTCTGCCAGTGGATCATACGTGTAAAC
CAAGGACTTTCCATTAAACTGAGCTTCGATGATTTTAATACATATTATACAGATATATTA
GATATTTATGAAGGTGTAGGATCAAGCAAGATTTTAAGAGCTTCTATTTGGGAAACTAAT
CCTGGCACAATAAGAATTTTTTCCAACCAAGTTACTGCCACCTTTCTTATAGAATCTGAT
GAAAGTGATTATGTTGGCTTTAATGCAACATATACTGCATTTAACAGCAGTGAGCTTAAT
AATTATGAGAAAATTAATTGTAACTTTGAGGATGGCTTTTGTTTCTGGGTCCAGGATCTA
AATGATGATAATGAATGGGAAAGGATTCAGGGAAGCACCTTTTCTCCTTTTACTGGACCC
AATTTTGACCACACTTTTGGCAATGCTTCAGGATTTTACATTTCTACCCCAACTGGACCA
GGAGGGAGACAAGAACGAGTGGGGCTTTTAAGCCTCCCTTTGGACCCCACTTTGGAGCCA
GCTTGCCTTAGTTTCTGGTATCATATGTATGGTGAAAATGTCCATAAATTAAGCATTAAT
ATCAGCAATGACCAAAATATGGAGAAGACAGTTTTCCAAAAGGAAGGAAATTATGGAGAC
AATTGGAATTATGGACAAGTAACCCTAAATGAAACAGTTAAATTTAAGGTTGCTTTTAAT
GCTTTTAAAAACAAGATCCTGAGTGATATTGCGTTGGATGACATTAGCCTAACATATGGG
ATTTGCAATGGGAGTCTTTATCCAGAACCAACTTTGGTGCCAACTCCTCCACCAGAACTT
CCTACGGACTGTGGAGGACCTTTTGAGCTGTGGGAGCCAAATACAACATTCAGTTCTACG
AACTTTCCAAACAGCTACCCTAATCTGGCTTTCTGTGTTTGGATTTTAAATGCACAAAAA
GGAAAGAATATACAACTTCATTTTCAAGAATTTGACTTAGAAAATATTAACGATGTAGTT
GAAATAAGAGATGGTGAAGAAGCTGATTCCTTGCTCTTAGCTGTGTACACAGGGCCTGGC
CCAGTAAAGGATGTGTTCTCTACCACCAACAGAATGACTGTGCTTCTCATCACTAACGAT
GTGTTGGCAAGAGGAGGGTTTAAAGCAAACTTTACTACTGGCTATCACTTGGGGATTCCA
GAGCCATGCAAGGCAGACCATTTTCAATGTAAAAATGGAGAGTGTGTTCCACTGGTGAAT
CTCTGTGACGGTCATCTGCACTGTGAGGATGGCTCAGATGAAGCAGATTGTGTGCGTTTT
TTCAATGGCACAACGAACAACAATGGTTTAGTGCGGTTCAGAATCCAGAGCATATGGCAT
ACAGCTTGTGCTGAGAACTGGACCACCCAGATTTCAAATGATGTTTGTCAACTGCTGGGA
CTAGGGAGTGGAAACTCATCAAAGCCAATCTTCTCTACCGATGGTGGACCATTTGTCAAA
TTAAACACAGCACCTGATGGCCACTTAATACTAACACCCAGTCAACAGTGTTTACAGGAT
TCCTTGATTCGGTTACAGTGTAACCATAAATCTTGTGGAAAAAAACTGGCAGCTCAAGAC
ATCACCCCAAAGATTGTTGGAGGAAGTAATGCCAAAGAAGGGGCCTGGCCCTGGGTTGTG
GGTCTGTATTATGGCGGCCGACTGCTCTGCGGCGCATCTCTCGTCAGCAGTGACTGGCTG
GTGTCCGCCGCACACTGCGTGTATGGGAGAAACTTAGAGCCATCCAAGTGGACAGCAATC
CTAGGCCTGCATATGAAATCAAATCTGACCTCTCCTCAAACAGTCCCTCGATTAATAGAT
GAAATTGTCATAAACCCTCATTACAATAGGCGAAGAAAGGACAACGACATTGCCATGATG
CATCTGGAATTTAAAGTGAATTACACAGATTACATACAACCTATTTGTTTACCGGAAGAA
AATCAAGTTTTTCCTCCAGGAAGAAATTGTTCTATTGCTGGTTGGGGGACGGTTGTATAT
CAAGGTACTACTGCAAACATATTGCAAGAAGCTGATGTTCCTCTTCTATCAAATGAGAGA
TGCCAACAGCAGATGCCAGAATATAACATTACTGAAAATATGATATGTGCAGGCTATGAA
GAAGGAGGAATAGATTCTTGTCAGGGGGATTCAGGAGGACCATTAATGTGCCAAGAAAAC
AACAGGTGGTTCCTTGCTGGTGTGACCTCATTTGGATACAAGTGTGCCCTGCCTAATCGC
CCCGGAGTGTATGCCAGGGTCTCAAGGTTTACCGAATGGATACAAAGTTTTCTACATTAG


# Metabolic_Enzyme_5_GenBank_ID_Gene:
U09860

# Metabolic_Enzyme_5_Chromosome_Location:
Not Available

# Metabolic_Enzyme_5_Locus:
Not Available

# Metabolic_Enzyme_5_SNPs:
rs2824790; rs2824721; rs2824804; rs8134187; rs11088674; rs8130110; rs35987974; rs2273204; rs2824751; rs17698445; rs2027614; rs927; rs9979816; rs7276699; rs2824787; rs1023386; rs2824737; rs2824752; rs2824740; rs2824808; rs2824766; rs2824771; rs2824795; rs2824807; rs2824731; rs1023387; rs1023385; rs2824794; rs2824767; rs1540000; rs2824788; rs1028979; rs2824723; rs2824764; rs2824757; rs2824746; rs2824716; rs2824728; rs2824760; rs719521; rs1041406; rs722682; rs1023388; rs2824724; rs2824738; rs2824765; rs1888409; rs990261; rs2824773; rs2824719; rs2150384; rs2824748; rs2824720; rs2824768; rs2824714; rs1041805; rs2824796; rs2207387; rs2824725; rs2244884; rs2824770; rs1573442; rs2824718; rs2824713; rs2824762; rs1475893; rs7281534; rs2824803; rs2824726; rs2406174; rs1999289; rs2824753; rs4482570; rs6517805; rs2824717; rs2824747; rs724128; rs2824722; rs1155077; rs2824756; rs7277215; rs1474822; rs1023127; rs9984010; rs2824727; rs2824784; rs8130490; rs9978650; rs2824797; rs2824799; rs2824763; rs8131365; rs1474823; rs2824772; rs2824742; rs6517803; rs2824778; rs3787593; rs2824750; rs2824749; rs8130250; rs2210228; rs7275997; rs2144204; rs2824739; rs3787580; rs8132055; rs2824785; rs2824745; rs9305864; rs2824754; rs2824715; rs1888410; rs7283555; rs8131942; rs1079663; rs2824732; rs2824774; rs2824805; rs2824780; rs2210227; rs2824729; rs2824743; rs985824; rs7276303; rs2144205; rs2824761; rs2824733; rs2824776; rs989891; rs974400; rs7277468; rs2824775; rs2824806; rs6517810; rs2824744; rs2824786; rs2824802; rs7283398; rs2824769; rs2824734; rs1474825; rs2207386; rs2824730; rs990214; rs3787590; rs11909148; rs10222071; rs2824800; rs10084582; rs997087; rs2824791; rs985825; rs985326; rs2824781; rs6517809; rs997088; rs11911826; rs4322926; rs2824736; rs7279876; rs990213; rs7282215; rs10084581; rs2824782; rs1023126; rs9977229; rs4143364; rs9305863; rs9982848; rs17771186; rs17781453; rs7280630; rs8133512; rs7283748; rs9983637; rs10482896; rs7277098; rs9980774; rs726489; rs8127494; rs8132226; rs2207385; rs8133003; rs1155847; rs726490; rs2225405; rs8130332; rs9983921; rs8130254; rs7281437; rs8128746; rs1474824; rs2406176; rs7278326; rs7279538; rs12483073; rs11700830; rs1040634; rs8134661; rs2824798; rs11911916; rs11909758; rs10482897; rs9305859; rs2225404; rs2824779; rs8134450; rs2824801; rs7278018; rs9980111; rs2824758; rs6517804; rs2824755; rs11702128; rs9305865; rs3787592; rs2824759; rs985327; rs1040633; rs17699052; rs10084615; rs4452233; rs2824792; rs17836432; rs11911274; rs9974453; rs10222073; rs7283358; rs7279594; rs4507184; rs3787582; rs12627490; rs9978427; rs7283355; rs4395327; rs13046004; rs11908859; rs10222197; rs7281938; rs17781093; rs8127654; rs17002539; rs10222065; rs17002571; rs13050432; rs4557074; rs8126494; rs7281980; rs7281315; rs13047640; rs7276475; rs10222194; rs7279017; rs11702131; rs6517811; rs9305862; rs17002576; rs13050461; rs10084622; rs9983765; rs11702854; rs3787581; rs3859710; rs10222066; rs9305860; rs17002579; rs8130619; rs17002589; rs9982094; rs2824741; rs2210229; rs9982295; rs9981155; rs12482824; rs7277309; rs1970047; rs11702545; rs743379; rs7278155; rs7282891; rs7283015; rs7275641; rs8126615; rs8127480; rs2154691; rs17002545; rs9977711; rs11702698; rs7281295; rs2824777; rs17836380; rs1474821; rs11702334; rs11909781; rs2298406; rs17002585; rs2824783; rs13052606; rs9983373; rs750084; rs11909416; rs9305861; rs9979516; rs9981106; rs17002532; rs10222198; rs17002548; rs9983837; rs8126674; rs6517807; rs2027613; rs2824793; rs10854427; rs2824735; rs7282779; rs2144203; rs12627311; rs17771793; rs17836456; rs8130239; rs10084618; rs17781399; rs2207384; rs7282391; rs7283085; rs7281997; rs11909952; rs8127478; rs17771702; rs9983501; rs9978705; rs997086; rs2027612; rs17836378; rs8126607; rs8128177; rs11088673; rs11910808; rs13047771; rs13052044; rs34543832; rs2051359; rs2824712; rs4312576; rs1569835; rs9975674; rs9979147; rs4493348; rs11088672; rs12626834; rs34162864; rs36047222; rs1005; rs35098038; rs7278479; rs7276084; rs8126887; rs34402555; rs13052987; rs11276239; rs1023384; rs34582893; rs9976107; rs3787583; rs34484160; rs12627091; rs13047058; rs35990835; rs28532285; rs10222190; rs17002592; rs34859334; rs35171230; rs2897386; rs13047487; rs28485981; rs11415439; rs1118289; rs4571147; rs8129347; rs10711798; rs28520584; rs7364052; rs28436100; rs28503505; rs35081352; rs36105980; rs743380; rs11360491; rs35734028; rs12483433; rs35326743; rs28555397; rs13049874; rs5842687; rs17002565; rs9984181; rs10692651; rs36008545; rs2210226; rs2039251; rs35032801; rs35775458; rs34158404; rs3082172; rs13050192; rs10084570; rs28549104; rs35152086; rs34401752; rs3215891; rs10655380; rs10522756; rs8130892; rs28368710; rs9983169; rs7283087; rs3082168; rs34494313; rs9975296; rs35794591; rs10716082; rs34250702; rs11342942; rs28698883; rs34000631; rs9974380; rs11445711; rs8128003; rs34807048; rs35606282; rs28523855; rs17002629; rs9975548; rs34336190; rs28427028; rs28533761; rs28660362; rs28605207; rs35796863; rs5842682; rs35422651; rs34998887; rs9974961; rs8128121; rs4380333; rs8134400; rs11359024; rs9981260; rs34646259; rs34421539; rs7282954; rs13046109; rs34185085; rs8128136; rs35194749; rs5842686; rs10673626; rs8132178; rs11088675; rs7283485; rs17002547; rs4622814; rs13046051; rs35428923; rs3077993; rs28564713; rs33969369; rs13049231; rs13050218; rs7364087; rs35936554; rs4401286; rs10655381; rs28436812; rs10646189; rs13049960; rs35449329; rs10451745; rs35096074; rs7283650; rs9984448; rs4446140; rs9979507; rs3838063; rs10084609; rs8128038; rs9978155; rs35745106; rs41421549; rs11274502; rs35008192; rs10700342; rs34745418; rs34819616; rs9984682; rs7283118; rs34233774; rs6147433; rs12481767; rs9975718; rs9976109; rs7282782; rs12483255; rs28602344; rs5842685; rs35623451; rs8127234; rs5842681; rs13052998; rs17699350; rs34505525; rs9975116; rs33940921; rs10583675; rs4571148; rs34172485; rs10541071; rs35011121; rs11277295; rs13050741; rs3787584; rs11700619; rs35859531; rs34232905; rs997089; rs11415685; rs9983629; rs13050848; rs34897835; rs8132001; rs34703253; rs7275275; rs34859096; rs34924498; rs28637313; rs5842679; rs10854426; rs35050572; rs28438747; rs34851604; rs735587; rs34897917; rs34428802; rs8135009; rs9979832; rs10154181; rs9978711; rs34787707; rs34738152; rs10531849; rs34006357; rs5842683; rs9982987; rs10544329; rs34888947; rs35909926; rs28691719; rs7283705; rs13049006; rs13047279; rs3077991; rs3077967; rs8133660; rs35493450; rs13049075; rs9941891; rs11353083; rs11360557; rs34737434; rs34084673; rs11357306; rs10701453; rs35335139; rs3859709; rs35459605; rs28713519; rs34247769; rs35449998; rs13048566; rs5842680; rs35075011; rs11438174; rs9979312; rs12626940; rs28473094; rs35986295; rs34089904; rs2406175; rs10537881; rs13047621; rs4578944; rs35329978; rs8127878; rs35990274; rs7282946; rs34073617; rs3991146; rs3077964; rs3077965; rs34733991; rs1034317; rs35493306; rs35893025; rs34942696; rs35820113; rs34824949; rs35184231; rs1051520; rs1051526; rs1051530; rs11088671; rs11909235; rs11909352; rs11909449; rs11911895; rs11911907; rs12627551; rs2051357; rs2051358; rs2180022; rs2210231; rs2252042; rs2300513; rs2300514; rs2824809; rs2824810; rs2824811; rs34172611; rs36042528; rs3827160; rs3920685; rs4381857; rs7276893; rs8130195; rs8132893; rs9979144; rs9980992; rs9984371

# Metabolic_Enzyme_5_General_References:
7718557; 11719902; 10830953; 8052624

# Metabolic_Enzyme_5_References:
7479669

# Metabolic_Enzyme_6_ID:
8278

# Metabolic_Enzyme_6_Name:
Ectonucleoside triphosphate diphosphohydrolase 2

# Metabolic_Enzyme_6_Synonyms:
Not Available

# Metabolic_Enzyme_6_Gene_Name:
ENTPD2

# Metabolic_Enzyme_6_Protein_Sequence:
>Ectonucleoside triphosphate diphosphohydrolase 2
MAGKVRSLLPPLLLAAAGLAGLLLLCVPTRDVREPPALKYGIVLDAGSSHTSMFIYKWPA
DKENDTGIVGQHSSCDVPGGGISSYADNPSGASQSLVGCLEQALQDVPKERHAGTPLYLG
ATAGMRLLNLTNPEASTSVLMAVTHTLTQYPFDFRGARILSGQEEGVFGWVTANYLLENF
IKYGWVGRWFRPRKGTLGAMDLGGASTQITFETTSPAEDRASEVQLHLYGQHYRVYTHSF
LCYGRDQVLQRLLASALQTHGFHPCWPRGFSTQVLLGDVYQSPCTMAQRPQNFNSSARVS
LSGSSDPHLCRDLVSGLFSFSSCPFSRCSFNGVFQPPVAGNFVAFSAFFYTVDFLRTSMG
LPVATLQQLEAAAVNVCNQTWAQQLLSRGYGFDERAFGGVIFQKKAADTAVGWALGYMLN
LTNLIPADPPGLRKGTDFSSWVVLLLLFASALLAALVLLLRQVHSAKLPSTI

# Metabolic_Enzyme_6_Number_of_Residues:
472

# Metabolic_Enzyme_6_Molecular_Weight:
51162

# Metabolic_Enzyme_6_Theoretical_pI:
8.10

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Not Available

# Metabolic_Enzyme_6_Pathway:
Not Available

# Metabolic_Enzyme_6_Reaction:
Not Available

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF01150:GDA1_CD39

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
7-29; 438-460

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.6.1.3

# Metabolic_Enzyme_6_GenBank_ID_Protein:
55962657

# Metabolic_Enzyme_6_SwissProt_ID:
Q5SPY6_HUMAN (Q5SPY6)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ENTPD2

# Metabolic_Enzyme_6_Geneatlas_id:
ENTPD2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:3364

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_6_Gene_Sequence:
>1419 bp
ATGGCCGGGAAGGTGCGGTCACTGCTGCCGCCGCTGCTGCTGGCCGCCGCGGGCCTCGCC
GGCCTCCTACTGCTGTGCGTCCCCACCCGCGACGTCCGGGAGCCGCCCGCCCTCAAGTAT
GGCATCGTCCTGGACGCTGGTTCTTCACACACGTCCATGTTTATCTACAAGTGGCCGGCA
GACAAGGAGAACGACACAGGCATTGTGGGCCAGCACAGCTCCTGTGATGTTCCAGGTGGG
GGCATCTCCAGCTATGCAGACAACCCTTCTGGGGCCAGCCAGAGTCTTGTTGGATGCCTC
GAACAGGCGCTTCAGGATGTGCCCAAAGAGAGACACGCGGGCACACCCCTCTACCTGGGA
GCCACAGCGGGTATGCGCCTGCTCAACCTGACCAATCCAGAGGCCTCGACCAGTGTGCTC
ATGGCAGTGACTCACACACTGACCCAGTACCCCTTTGACTTCCGGGGTGCACGCATCCTC
TCGGGCCAGGAAGAGGGGGTGTTTGGCTGGGTGACTGCCAACTACCTGCTGGAGAACTTC
ATCAAGTACGGCTGGGTGGGCCGGTGGTTCCGGCCACGGAAGGGGACACTGGGGGCCATG
GACCTGGGGGGTGCCTCTACCCAGATCACTTTTGAGACAACCAGTCCAGCTGAGGACAGA
GCCAGCGAGGTCCAGCTGCATCTCTACGGCCAGCACTACCGAGTCTACACCCACAGCTTC
CTCTGCTATGGCCGTGACCAGGTCCTCCAGAGGCTGCTGGCCAGCGCCCTCCAGACCCAC
GGCTTCCACCCCTGCTGGCCGAGGGGCTTTTCCACCCAAGTGCTGCTCGGGGATGTGTAC
CAGTCACCATGCACCATGGCCCAGCGGCCCCAGAACTTCAACAGCAGTGCCAGGGTCAGC
CTGTCAGGGAGCAGTGACCCCCACCTCTGCCGAGATCTGGTTTCTGGGCTCTTCAGCTTC
TCCTCCTGCCCCTTCTCCCGATGCTCTTTCAATGGGGTCTTCCAGCCCCCAGTGGCTGGG
AACTTTGTGGCCTTCTCTGCCTTCTTCTACACTGTGGACTTTTTGCGGACTTCGATGGGG
CTGCCCGTGGCCACCCTGCAGCAGCTGGAGGCAGCCGCAGTGAATGTCTGCAACCAGACC
TGGGCTCAGCAGCTGCTGAGTCGCGGCTACGGCTTCGACGAGCGCGCCTTCGGCGGCGTG
ATCTTCCAGAAGAAGGCCGCGGACACTGCAGTGGGCTGGGCGCTCGGCTACATGCTGAAC
CTGACCAACCTGATCCCCGCCGACCCGCCGGGGCTGCGCAAGGGCACAGACTTCAGCTCC
TGGGTCGTCCTCCTGCTGCTCTTCGCCTCCGCGCTCCTGGCTGCGCTTGTCCTGCTGCTG
CGTCAGGTGCACTCCGCCAAGCTGCCAAGCACCATTTAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AL807752

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_6_Locus:
9q34

# Metabolic_Enzyme_6_SNPs:
rs34618694; rs7873815; rs4880083; rs2292925; rs7861020; rs11145979; rs7390981; rs7024097; rs12005251; rs12555382; rs10735661; rs7848899; rs10870170; rs7869777; rs12004425; rs11145977; rs12005729; rs7860436; rs7869655; rs11145976; rs3763661; rs12551623; rs7390933; rs3763662; rs35983961; rs11539737; rs17853460; rs2271866; rs17853461; rs35674457; rs7041887; rs33994273; rs28545468; rs2271867; rs12004426; rs12554236; rs34679600; rs10870169; rs34657628; rs4880084; rs2292924; rs7869520; rs5023370; rs1568352; rs34616561; rs13292220; rs5023369; rs34429443; rs11788719; rs9411242; rs34832424; rs3750514; rs10781534; rs11145975; rs11145980; rs13289619; rs35547344; rs3750517; rs3763663; rs3814504; rs3829107; rs4273935; rs4880085; rs6605; rs7026504; rs7038280; rs7388830; rs9411299

# Metabolic_Enzyme_6_General_References:
Not Available

# Metabolic_Enzyme_6_References:
8106499

# Macromolecular_Interacting_Partner_1_ID:
7519

# Macromolecular_Interacting_Partner_1_Name:
Canalicular multispecific organic anion transporter 2

# Macromolecular_Interacting_Partner_1_Synonyms:
ATP-binding cassette sub-family C member 3; Multidrug resistance-associated protein 3; Multi-specific organic anion transporter-D; MOAT-D

# Macromolecular_Interacting_Partner_1_Gene_Name:
ABCC3

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Canalicular multispecific organic anion transporter 2
MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL
WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL
KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS
MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF
MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ
MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM
CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLK
RIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVV
GPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRY
QQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSA
VDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ
RNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQ
KQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFW
DYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGI
LQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVD
EVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLE
SVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVE
FVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERV
KEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVG
IVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTL
RMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARAL
LRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGV
VAEFDSPANLIAARGIFYGMARDAGLA

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
1527

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
169345

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.20

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  transporter activity
Function:  ATPase activity
Function:  hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Function:  ATPase activity, coupled to transmembrane movement of substances
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_1_Specific_Function:
May act as an inducible transporter in the biliary and intestinal excretion of organic anions

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00664:ABC_membrane;
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
33-53
74-94
100-120
133-153
172-192
303-323
350-370
427-447
451-471
534-554
577-597
964-984
1022-1042
1086-1106
1108-1128
1200-1220
1223-1243

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
3132270

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
MRP3_HUMAN (O15438)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
ABCC3

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
ABCC3

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:54

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>4584 bp
ATGGACGCCCTGTGCGGTTCCGGGGAGCTCGGCTCCAAGTTCTGGGACTCCAACCTGTCT
GTGCACACAGAAAACCCGGACCTCACTCCCTGCTTCCAGAACTCCCTGCTGGCCTGGGTG
CCCTGCATCTACCTGTGGGTCGCCCTGCCCTGCTACTTGCTCTACCTGCGGCACCATTGT
CGTGGCTACATCATCCTCTCCCACCTGTCCAAGCTCAAGATGGTCCTGGGTGTCCTGCTG
TGGTGCGTCTCCTGGGCAGACCTTTTTTACTCCTTCCATGGCCTGGTCCATGGCCGGGCC
CCTGCCCCTGTTTTCTTTGTCACCCCCTTGGTGGTGGGGGTCACCATGCTGCTGGCCACC
CTGCTGATACAGTATGAGCGGCTGCAGGGCGTACAGTCTTCGGGGGTCCTCATTATCTTC
TGGTTCCTGTGTGTGGTCTGCGCCATCGTCCCATTCCGCTCCAAGATCCTTTTAGCCAAG
GCAGAGGGTGAGATCTCAGACCCCTTCCGCTTCACCACCTTCTACATCCACTTTGCCCTG
GTACTCTCTGCCCTCATCTTGGCCTGCTTCAGGGAGAAACCTCCATTTTTCTCCGCAAAG
AATGTCGACCCTAACCCCTACCCTGAGACCAGCGCTGGCTTTCTCTCCCGCCTGTTTTTC
TGGTGGTTCACAAAGATGGCCATCTATGGCTACCGGCATCCCCTGGAGGAGAAGGACCTC
TGGTCCCTAAAGGAAGAGGACAGATCCCAGATGGTGGTGCAGCAGCTGCTGGAGGCATGG
AGGAAGCAGGAAAAGCAGACGGCACGACACAAGGCTTCAGCAGCACCTGGGAAAAATGCC
TCCGGCGAGGACGAGGTGCTGCTGGGTGCCCGGCCCAGGCCCCGGAAGCCCTCCTTCCTG
AAGGCCCTGCTGGCCACCTTCGGCTCCAGCTTCCTCATCAGTGCCTGCTTCAAGCTTATC
CAGGACCTGCTCTCCTTCATCAATCCACAGCTGCTCAGCATCCTGATCAGGTTTATCTCC
AACCCCATGGCCCCCTCCTGGTGGGGCTTCCTGGTGGCTGGGCTGATGTTCCTGTGCTCC
ATGATGCAGTCGCTGATCTTACAACACTATTACCACTACATCTTTGTGACTGGGGTGAAG
TTTCGTACTGGGATCATGGGTGTCATCTACAGGAAGGCTCTGGTTATCACCAACTCAGTC
AAACGTGCGTCCACTGTGGGGGAAATTGTCAACCTCATGTCAGTGGATGCCCAGCGCTTC
ATGGACCTTGCCCCCTTCCTCAATCTGCTGTGGTCAGCACCCCTGCAGATCATCCTGGCG
ATCTACTTCCTCTGGCAGAACCTAGGTCCCTCTGTCCTGGCTGGAGTCGCTTTCATGGTC
TTGCTGATTCCACTCAACGGAGCTGTGGCCGTGAAGATGCGCGCCTTCCAGGTAAAGCAA
ATGAAATTGAAGGACTCGCGCATCAAGCTGATGAGTGAGATCCTGAACGGCATCAAGGTG
CTGAAGCTGTACGCCTGGGAGCCCAGCTTCCTGAAGCAGGTGGAGGGCATCAGGCAGGGT
GAGCTCCAGCTGCTGCGCACGGCGGCCTACCTCCACACCACAACCACCTTCACCTGGATG
TGCAGCCCCTTCCTGGTGACCCTGATCACCCTCTGGGTGTACGTGTACGTGGACCCAAAC
AATGTGCTGGACGCCGAGAAGGCCTATGTGTCTGTGTCCTTGTTTAATATCTTAAGACTT
CCCCTCAACATGCTGCCCCAGTTAATCAGCAACCTGACTCAGGCCAGTGTGTCTCTGAAA
CGGATCCAGCAATTCCTGAGCCAAGAGGAACTTGACCCCCAGAGTGTGGAAAGAAAGACC
ATCTCCCCAGGCTATGCCATCACCATACACAGTGGCACCTTCACCTGGGCCCAGGACCTG
CCCCCCACTCTGCACAGCCTAGACATCCAGGTCCCGAAAGGGGCACTGGTGGCCGTGGTG
GGGCCTGTGGGCTGTGGGAAGTCCTCCCTGGTGTCTGCCCTGCTGGGAGAGATGGAGAAG
CTAGAAGGCAAAGTGCACATGAAGGGCTCCGTGGCCTATGTGCCCCAGCAGGCATGGATC
CAGAACTGCACTCTTCAGGAAAACGTGCTTTTCGGCAAAGCCCTGAACCCCAAGCGCTAC
CAGCAGACTCTGGAGGCCTGTGCCTTGCTAGCTGACCTGGAGATGCTGCCTGGTGGGGAT
CAGACAGAGATTGGAGAGAAGGGCATTAACCTGTCTGGGGGCCAGCGGCAGCGGGTCAGT
CTGGCTCGAGCTGTTTACAGTGATGCCGATATTTTCTTGCTGGATGACCCACTGTCCGCG
GTGGACTCTCATGTGGCCAAGCACATCTTTGACCACGTCATCGGGCCAGAAGGCGTGCTG
GCAGGCAAGACGCGAGTGCTGGTGACGCACGGCATTAGCTTCCTGCCCCAGACAGACTTC
ATCATTGTGCTAGCTGATGGACAGGTGTCTGAGATGGGCCCGTACCCAGCCCTGCTGCAG
CGCAACGGCTCCTTTGCCAACTTTCTCTGCAACTATGCCCCCGATGAGGACCAAGGGCAC
CTGGAGGACAGCTGGACCGCGTTGGAAGGTGCAGAGGATAAGGAGGCACTGCTGATTGAA
GACACACTCAGCAACCACACGGATCTGACAGACAATGATCCAGTCACCTATGTGGTCCAG
AAGCAGTTTATGAGACAGCTGAGTGCCCTGTCCTCAGATGGGGAGGGACAGGGTCGGCCT
GTACCCCGGAGGCACCTGGGTCCATCAGAGAAGGTGCAGGTGACAGAGGCGAAGGCAGAT
GGGGCACTGACCCAGGAGGAGAAAGCAGCCATTGGCACTGTGGAGCTCAGTGTGTTCTGG
GATTATGCCAAGGCCGTGGGGCTCTGTACCACGCTGGCCATCTGTCTCCTGTATGTGGGT
CAAAGTGCGGCTGCCATTGGAGCCAATGTGTGGCTCAGTGCCTGGACAAATGATGCCATG
GCAGACAGTAGACAGAACAACACTTCCCTGAGGCTGGGCGTCTATGCTGCTTTAGGAATT
CTGCAAGGGTTCTTGGTGATGCTGGCAGCCATGGCCATGGCAGCGGGTGGCATCCAGGCT
GCCCGTGTGTTGCACCAGGCACTGCTGCACAACAAGATACGCTCGCCACAGTCCTTCTTT
GACACCACACCATCAGGCCGCATCCTGAACTGCTTCTCCAAGGACATCTATGTCGTTGAT
GAGGTTCTGGCCCCTGTCATCCTCATGCTGCTCAATTCCTTCTTCAACGCCATCTCCACT
CTTGTGGTCATCATGGCCAGCACGCCGCTCTTCACTGTGGTCATCCTGCCCCTGGCTGTG
CTCTACACCTTAGTGCAGCGCTTCTATGCAGCCACATCACGGCAACTGAAGCGGCTGGAA
TCAGTCAGCCGCTCACCTATCTACTCCCACTTTTCGGAGACAGTGACTGGTGCCAGTGTC
ATCCGGGCCTACAACCGCAGCCGGGATTTTGAGATCATCAGTGATACTAAGGTGGATGCC
AACCAGAGAAGCTGCTACCCCTACATCATCTCCAACCGGTGGCTGAGCATCGGAGTGGAG
TTCGTGGGGAACTGCGTGGTGCTCTTTGCTGCACTATTTGCCGTCATCGGGAGGAGCAGC
CTGAACCCGGGGCTGGTGGGCCTTTCTGTGTCCTACTCCTTGCAGGTGACATTTGCTCTG
AACTGGATGATACGAATGATGTCAGATTTGGAATCTAACATCGTGGCTGTGGAGAGGGTC
AAGGAGTACTCCAAGACAGAGACAGAGGCGCCCTGGGTGGTGGAAGGCAGCCGCCCTCCC
GAAGGTTGGCCCCCACGTGGGGAGGTGGAGTTCCGGAATTATTCTGTGCGCTACCGGCCG
GGCCTAGACCTGGTGCTGAGAGACCTGAGTCTGCATGTGCATGGTGGCGAGAAGGTGGGG
ATCGTGGGCCGCACTGGGGCTGGCAAGTCTTCCATGACCCTTTGCCTGTTCCGCATCCTG
GAGGCGGCAAAGGGTGAAATCCGCATTGATGGCCTCAATGTGGCAGACATCGGCCTCCAT
GACCTGCGCTCTCAGCTGACCATCATCCCGCAGGACCCCATCCTGTTCTCGGGGACCCTG
CGCATGAACCTGGACCCCTTCGGCAGCTACTCAGAGGAGGACATTTGGTGGGCTTTGGAG
CTGTCCCACCTGCACACGTTTGTGAGCTCCCAGCCGGCAGGCCTGGACTTCCAGTGCTCA
GAGGGCGGGGAGAATCTCAGCGTGGGCCAGAGGCAGCTCGTGTGCCTGGCCCGAGCCCTG
CTCCGCAAGAGCCGCATCCTGGTTTTAGACGAGGCCACAGCTGCCATCGACCTGGAGACT
GACAACCTCATCCAGGCTACCATCCGCACCCAGTTTGATACCTGCACTGTCCTGACCATC
GCACACCGGCTTAACACTATCATGGACTACACCAGGGTCCTGGTCCTGGACAAAGGAGTA
GTAGCTGAGTTTGATTCTCCAGCCAACCTCATTGCAGCTAGAGGCATCTTCTACGGGATG
GCCAGAGATGCTGGACTTGCCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AB010887

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_1_Locus:
17q22

# Macromolecular_Interacting_Partner_1_SNPs:
rs11568591; rs4148416; rs2277624; rs1051640; rs11568589; rs872793; rs11568607; rs8075406; rs3785911; rs2240802; rs12451302; rs2301837; rs8077268; rs967935; rs2412333; rs739923; rs4148413; rs1548529; rs4148412; rs1978153; rs4148415; rs739921; rs11651958; rs16949207; rs4794173; rs3785912; rs739922; rs8076674; rs4148411; rs2107438; rs733392; rs1541391; rs2301836; rs879459; rs12051822; rs2240801; rs886493; rs2072366; rs7216383; rs4148405; rs8079432; rs9902630; rs17562516; rs886492; rs16949205; rs1541392; rs1558287; rs11870374; rs3785913; rs9905584; rs8070592; rs12451964; rs4794178; rs17562467; rs9893660; rs740786; rs7215354; rs9303560; rs11654404; rs7218932; rs11658264; rs9892309; rs16949202; rs4148409; rs11079922; rs719717; rs4793666; rs4794174; rs1137449; rs733393; rs17642714; rs11869371; rs8079556; rs10153257; rs2015146; rs3826434; rs11870410; rs11869370; rs12604031; rs4794175; rs9894568; rs12603393; rs11869632; rs1989983; rs4793665; rs9895420; rs17563146; rs1003355; rs11656685; rs1003354; rs1051625; rs11549764; rs41280128; rs41280126; rs28470592; rs28586870; rs34221557; rs12450249; rs35364174; rs9896793; rs1989283; rs12103933; rs1558288; rs875238; rs3892688; rs1989226; rs7224093; rs5024133; rs34201788; rs35824469; rs12103817; rs12943812; rs4638630; rs4794176; rs10714203; rs4148414; rs4794177; rs12940921; rs8082610; rs2066763; rs4148407; rs34847172; rs12946653; rs10608553; rs28489929; rs35452921; rs4148408; rs11653384; rs34582346; rs35792889; rs11300167; rs35231927; rs1974609; rs2023907; rs34498638; rs35977569; rs9891029; rs8064807; rs35369910; rs11079921; rs732760; rs34856648; rs9890046; rs35128486; rs34564586; rs3063105; rs35538577; rs34556513; rs3216955; rs12946683; rs36088946; rs12452686; rs4148410; rs35481482; rs28581563; rs7224691; rs5024132; rs35968768; rs35516930; rs4793667; rs35957356; rs9891165; rs4423464; rs35147050; rs12944018; rs5024134; rs2072365; rs4423465; rs11654892; rs35507460; rs34858494; rs3063107; rs7222959; rs34956109; rs35623528; rs5820828; rs5024131; rs1974608; rs4148403; rs35467079; rs34183195; rs10491146; rs11568580; rs11568582; rs11568583; rs11568584; rs11568586; rs11568587; rs11568588; rs11568590; rs11568595; rs11568596; rs11568597; rs11568598; rs11568599; rs11568600; rs11568602; rs11568604; rs11568606; rs11568608; rs11867598; rs12602161; rs14882; rs17717246; rs2107441; rs2107442; rs2189595; rs2214566; rs2286650; rs2412332; rs3180373; rs34675700; rs34958340; rs35999272; rs3815378; rs4148418; rs7212045; rs739925; rs757420; rs757421; rs8073706; rs8075158; rs8081077; rs8196; rs9455; rs9893223; rs9901250; rs9910012; rs9911750

# Macromolecular_Interacting_Partner_1_General_References:
9738950; 10094960; 9813153; 9889399; 9827529; 9270026

# Macromolecular_Interacting_Partner_1_References:
10987286; 12763363

# Macromolecular_Interacting_Partner_2_ID:
7531

# Macromolecular_Interacting_Partner_2_Name:
Bile salt export pump

# Macromolecular_Interacting_Partner_2_Synonyms:
ATP-binding cassette sub-family B member 11

# Macromolecular_Interacting_Partner_2_Gene_Name:
ABCB11

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Bile salt export pump
MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQLFRFSSSTDIW
LMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLN
QNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFR
RIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWK
LTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKRE
VERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYAVAFWYGSTLVLDEGEYTPGTLV
QIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEI
EFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVT
VDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNF
IMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEV
LSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQG
NQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKST
YEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQIL
GTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAML
GQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKL
SLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFI
EALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRV
ISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDF
VDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMID
GHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDF
VMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVA
LDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSPI
S

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
1321

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
146395

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.52

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  ATPase activity
Function:  hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Function:  ATPase activity, coupled to transmembrane movement of substances
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_2_Specific_Function:
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00664:ABC_membrane;
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
63-83
148-168
216-236
241-261
320-340
354-374
756-776
795-815
870-890
891-911
980-1000
1012-1032

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
3873243

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
ABCBB_HUMAN (O95342)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
ABCB11

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
ABCB11

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:42

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>3966 bp
ATGTCTGACTCAGTAATTCTTCGAAGTATAAAGAAATTTGGAGAGGAGAATGATGGTTTT
GAGTCAGATAAATCATATAATAATGATAAGAAATCAAGGTTACAAGATGAGAAGAAAGGT
GATGGCGTTAGAGTTGGCTTCTTTCAATTGTTTCGGTTTTCTTCATCAACTGACATTTGG
CTGATGTTTGTGGGAAGTTTGTGTGCATTTCTCCATGGAATAGCCCAGCCAGGCGTGCTA
CTCATTTTTGGCACAATGACAGATGTTTTTATTGACTACGACGTTGAGTTACAAGAACTC
CAGATTCCAGGAAAAGCATGTGTGAATAACACCATTGTATGGACTAACAGTTCCCTCAAC
CAGAACATGACAAATGGAACACGTTGTGGGTTGCTGAACATCGAGAGCGAAATGATCAAA
TTTGCCAGTTACTATGCTGGAATTGCTGTCGCAGTACTTATCACAGGATATATTCAAATA
TGCTTTTGGGTCATTGCCGCAGCTCGTCAGATACAGAAAATGAGAAAATTTTACTTTAGG
AGAATAATGAGAATGGAAATAGGGTGGTTTGACTGCAATTCAGTGGGGGAGCTGAATACA
AGATTCTCTGATGATATTAATAAAATCAATGATGCCATAGCTGACCAAATGGCCCTTTTC
ATTCAGCGCATGACCTCGACCATCTGTGGTTTCCTGTTGGGATTTTTCAGGGGTTGGAAA
CTGACCTTGGTTATTATTTCTGTCAGCCCTCTCATTGGGATTGGAGCAGCCACCATTGGT
CTGAGTGTGTCCAAGTTTACGGACTATGAGCTGAAGGCCTATGCCAAAGCAGGGGTGGTG
GCTGATGAAGTCATTTCATCAATGAGAACAGTGGCTGCTTTTGGTGGTGAGAAAAGAGAG
GTTGAAAGGTATGAGAAAAATCTTGTGTTCGCCCAGCGTTGGGGAATTAGAAAAGGAATA
GTGATGGGATTCTTTACTGGATTCGTGTGGTGTCTCATCTTTTTGTGTTATGCAGTGGCC
TTCTGGTACGGCTCCACACTTGTCCTGGATGAAGGAGAATATACACCAGGAACCCTTGTC
CAGATTTTCCTCAGTGTCATAGTAGGAGCTTTAAATCTTGGCAATGCCTCTCCTTGTTTG
GAAGCCTTTGCAACTGGACGTGCAGCAGCCACCAGCATTTTTGAGACAATAGACAGGAAA
CCCATCATTGACTGCATGTCAGAAGATGGTTACAAGTTGGATCGAATCAAGGGTGAAATT
GAATTCCATAATGTGACCTTCCATTATCCTTCCAGACCAGAGGTGAAGATTCTAAATGAC
CTCAACATGGTCATTAAACCAGGGGAAATGACAGCTCTGGTAGGACCCAGTGGAGCTGGA
AAAAGTACAGCACTGCAACTCATTCAGCGATTCTATGACCCCTGTGAAGGAATGGTGACC
GTGGATGGCCATGACATTCGCTCTCTTAACATTCAGTGGCTTAGAGATCAGATTGGGATA
GTGGAGCAAGAGCCAGTTCTGTTCTCTACCACCATTGCAGAAAATATTCGCTATGGCAGA
GAAGATGCAACAATGGAAGACATAGTCCAAGCTGCCAAGGAGGCCAATGCCTACAACTTC
ATCATGGACCTGCCACAGCAATTTGACACCCTTGTTGGAGAAGGAGGAGGCCAGATGAGT
GGTGGCCAGAAACAAAGGGTAGCTATCGCCAGAGCCCTCATCCGAAATCCCAAGATTCTG
CTTTTGGACATGGCCACCTCAGCTCTGGACAATGAGAGTGAAGCCATGGTGCAAGAAGTG
CTGAGTAAGATTCAGCATGGGCACACAATCATTTCAGTTGCTCATCGCTTGTCTACGGTC
AGAGCTGCAGATACCATCATTGGTTTTGAACATGGCACTGCAGTGGAAAGAGGGACCCAT
GAAGAATTACTGGAAAGGAAAGGTGTTTACTTCACTCTAGTGACTTTGCAAAGCCAGGGA
AATCAAGCTCTTAATGAAGAGGACATAAAGGATGCAACTGAAGATGACATGCTTGCGAGG
ACCTTTAGCAGAGGGAGCTACCAGGATAGTTTAAGGGCTTCCATCCGGCAACGCTCCAAG
TCTCAGCTTTCTTACCTGGTGCACGAACCTCCATTAGCTGTTGTAGATCATAAGTCTACC
TATGAAGAAGATAGAAAGGACAAGGACATTCCTGTGCAGGAAGAAGTTGAACCTGCCCCA
GTTAGGAGGATTCTGAAATTCAGTGCTCCAGAATGGCCCTACATGCTGGTAGGGTCTGTG
GGTGCAGCTGTGAACGGGACAGTCACACCCTTGTATGCCTTTTTATTCAGCCAGATTCTT
GGGACTTTTTCAATTCCTGATAAAGAGGAACAAAGGTCACAGATCAATGGTGTGTGCCTA
CTTTTTGTAGCAATGGGCTGTGTATCTCTTTTCACCCAATTTCTACAGGGATATGCCTTT
GCTAAATCTGGGGAGCTCCTAACAAAAAGGCTACGTAAATTTGGTTTCAGGGCAATGCTG
GGGCAAGATATTGCCTGGTTTGATGACCTCAGAAATAGCCCTGGAGCATTGACAACAAGA
CTTGCTACAGATGCTTCCCAAGTTCAAGGGGCTGCCGGCTCTCAGATCGGGATGATAGTC
AATTCCTTCACTAACGTCACTGTGGCCATGATCATTGCCTTCTCCTTTAGCTGGAAGCTG
AGCCTGGTCATCTTGTGCTTCTTCCCCTTCTTGGCTTTATCAGGAGCCACACAGACCAGG
ATGTTGACAGGATTTGCCTCTCGAGATAAGCAGGCCCTGGAGATGGTGGGACAGATTACA
AATGAAGCCCTCAGTAACATCCGCACTGTTGCTGGAATTGGAAAGGAGAGGCGGTTCATT
GAAGCACTTGAGACTGAGCTGGAGAAGCCCTTCAAGACAGCCATTCAGAAAGCCAATATT
TACGGATTCTGCTTTGCCTTTGCCCAGTGCATCATGTTTATTGCGAATTCTGCTTCCTAC
AGATATGGAGGTTACTTAATCTCCAATGAGGGGCTCCATTTCAGCTATGTGTTCAGGGTG
ATCTCTGCAGTTGTACTGAGTGCAACAGCTCTTGGAAGAGCCTTCTCTTACACCCCAAGT
TATGCAAAAGCTAAAATATCAGCTGCACGCTTTTTTCAACTGCTGGACCGACAACCCCCA
ATCAGTGTATACAATACTGCAGGTGAAAAATGGGACAACTTCCAGGGGAAGATTGATTTT
GTTGATTGTAAATTTACATATCCTTCTCGACCTGACTCGCAAGTTCTGAATGGTCTCTCA
GTGTCGATTAGTCCAGGGCAGACACTGGCGTTTGTTGGGAGCAGTGGATGTGGCAAAAGC
ACTAGCATTCAGCTGTTGGAACGTTTCTATGATCCTGATCAAGGGAAGGTGATGATAGAT
GGTCATGACAGCAAAAAAGTAAATGTCCAGTTCCTCCGCTCAAACATTGGAATTGTTTCC
CAGGAACCAGTGTTGTTTGCCTGTAGCATAATGGACAATATCAAGTATGGAGACAACACC
AAAGAAATTCCCATGGAAAGAGTCATAGCAGCTGCAAAACAGGCTCAGCTGCATGATTTT
GTCATGTCACTCCCAGAGAAATATGAAACTAACGTTGGGTCCCAGGGGTCTCAACTCTCT
AGAGGGGAGAAACAACGCATTGCTATTGCTCGGGCCATTGTACGAGATCCTAAAATCTTG
CTACTAGATGAAGCCACTTCTGCCTTAGACACAGAAAGTGAAAAGACGGTGCAGGTTGCT
CTAGACAAAGCCAGAGAGGGTCGGACCTGCATTGTCATTGCCCATCGCTTGTCCACCATC
CAGAACGCGGATATCATTGCTGTCATGGCACAGGGGGTGGTGATTGAAAAGGGGACCCAT
GAAGAACTGATGGCCCAAAAAGGAGCCTACTACAAACTAGTCACCACTGGATCCCCCATC
AGTTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AF091582

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_2_Locus:
2q24

# Macromolecular_Interacting_Partner_2_SNPs:
rs11568357; rs2287622; rs2287617; rs1521808; rs11568361; rs7563233; rs11568377; rs497692; rs2287616; rs11568365; rs3815675; rs34200464; rs11568362; rs4148777; rs4148768; rs7578587; rs3770602; rs11892966; rs7602171; rs473351; rs495714; rs13416851; rs13430236; rs496550; rs11892650; rs12614405; rs12612685; rs12617788; rs13387523; rs3770603; rs4148772; rs10172523; rs34104195; rs35372131; rs11902424; rs12611596; rs13403581; rs3732038; rs13429894; rs4668115; rs13393726; rs4148770; rs10208125; rs494874; rs519887; rs853789; rs862662; rs853783; rs2685814; rs503931; rs853787; rs575671; rs2287618; rs555975; rs566879; rs3770582; rs13407866; rs484066; rs7602485; rs519035; rs3755157; rs10199694; rs2685805; rs6759871; rs11892887; rs6751546; rs853780; rs2241339; rs853772; rs6433100; rs853774; rs485094; rs7602204; rs10208831; rs13403911; rs6761690; rs3821120; rs853778; rs6709087; rs10192504; rs6433102; rs6733156; rs10170513; rs2241342; rs2058996; rs6759156; rs853785; rs10172795; rs3770599; rs13416802; rs2544360; rs1101531; rs486981; rs4148776; rs483234; rs508506; rs10179758; rs853788; rs3770593; rs551754; rs2287621; rs3770591; rs3755158; rs4148782; rs4148791; rs4148790; rs3897807; rs3770594; rs853773; rs2287613; rs4148783; rs2287615; rs6736455; rs508743; rs10208608; rs853775; rs3770592; rs567074; rs17267869; rs10211329; rs6433096; rs13404027; rs16856247; rs7605199; rs3770596; rs860510; rs2389610; rs2241341; rs853779; rs13403982; rs13400716; rs2389615; rs10176934; rs3770601; rs579060; rs6758316; rs2287614; rs12692889; rs10199881; rs4148784; rs11887272; rs7561903; rs853786; rs3770597; rs13432949; rs579275; rs6751775; rs4148793; rs11568378; rs4148798; rs853791; rs13404014; rs479682; rs3815676; rs569805; rs1402836; rs11902627; rs2241340; rs3770598; rs3770588; rs13384680; rs4140386; rs16856256; rs2892806; rs11901443; rs1101533; rs4148785; rs1581397; rs2287623; rs2389604; rs4148797; rs13404242; rs17540154; rs10188208; rs480562; rs16823014; rs552976; rs4148794; rs3755160; rs853784; rs853776; rs3770590; rs3770589; rs16856300; rs7560402; rs4148778; rs12613034; rs853781; rs569829; rs3770585; rs10184113; rs2389603; rs3770595; rs2287619; rs12621591; rs10200158; rs2193831; rs12618846; rs472614; rs10175055; rs6709971; rs16856258; rs13413844; rs10202842; rs10164496; rs10196984; rs4142230; rs7572878; rs10202892; rs2685810; rs34313070; rs3770587; rs2389605; rs10176901; rs16856332; rs9287908; rs12622271; rs10177080; rs7425273; rs10209995; rs2216503; rs2389608; rs35472607; rs2685811; rs7568243; rs35442846; rs6713587; rs2263243; rs11899077; rs16856314; rs13414957; rs10184334; rs2216502; rs10184421; rs11901379; rs3815677; rs2544367; rs7607790; rs3821121; rs7586497; rs9287906; rs11901292; rs2287620; rs2685812; rs10196426; rs2389607; rs3770583; rs11890609; rs16856261; rs11884980; rs853777; rs2685803; rs12477292; rs7566645; rs565412; rs2389611; rs16856327; rs4148780; rs36011224; rs11903009; rs508741; rs853782; rs35440743; rs11900829; rs34113235; rs2250677; rs2389609; rs2685813; rs7576531; rs13419622; rs3821122; rs4148773; rs34882395; rs3770584; rs10177015; rs2287612; rs2307959; rs864929; rs10208702; rs35178517; rs3836043; rs2389606; rs7570800; rs17267730; rs9287907; rs4148775; rs34532548; rs10206511; rs10167993; rs865528; rs16856252; rs10206671; rs4140387; rs2685807; rs10174358; rs13404228; rs531772; rs10200453; rs7558863; rs4148779; rs2216504; rs3829888; rs478333; rs557462; rs4148765; rs3814381; rs10930343; rs4148804; rs16856392; rs2947987; rs2241338; rs3814382; rs41265143; rs3755161; rs34782741; rs13390147; rs13397300; rs35236376; rs13425780; rs3834150; rs3755162; rs3836045; rs4148767; rs10198321; rs4148771; rs3755163; rs35322731; rs3770571; rs5836218; rs11393553; rs35314698; rs10178577; rs13015444; rs13390715; rs10181388; rs5836212; rs13382331; rs6724525; rs34998320; rs34497610; rs2544362; rs28556624; rs7419342; rs13395480; rs10579127; rs12990578; rs34477999; rs33988336; rs2893113; rs10184673; rs34210697; rs3836044; rs4148795; rs28719023; rs2893112; rs3770600; rs35384412; rs2272063; rs36089386; rs4142231; rs34130824; rs2632379; rs3770586; rs5836215; rs35728285; rs34539397; rs10168672; rs34376889; rs3084001; rs2685808; rs11898632; rs2193832; rs34307604; rs10533402; rs2632377; rs2544364; rs35351007; rs4148802; rs2544359; rs35908291; rs7566984; rs10687976; rs3841893; rs2389613; rs4148799; rs28810810; rs35201800; rs35103099; rs4148787; rs10636147; rs10533400; rs34849968; rs36121242; rs1101534; rs13393626; rs35174354; rs34526705; rs35501527; rs35362717; rs2544361; rs13428002; rs13389076; rs4667589; rs35120985; rs482508; rs10168323; rs7603227; rs11896548; rs10524072; rs2390792; rs35460880; rs12996841; rs853790; rs12996022; rs11302722; rs10533403; rs5836214; rs7605296; rs34135220; rs17268587; rs35101041; rs2389612; rs28374129; rs2544363; rs35051200; rs11356690; rs34760671; rs13410784; rs10624627; rs2685804; rs35964117; rs7580720; rs13420697; rs4148774; rs28689500; rs13389921; rs4148803; rs34285735; rs13404044; rs35592488; rs35297422; rs4148781; rs11457018; rs4668110; rs3898462; rs34483735; rs28578897; rs34627998; rs35279237; rs34996265; rs35960929; rs12463887; rs2544366; rs10533404; rs4148800; rs34287805; rs35050126; rs12477616; rs35127857; rs28735569; rs12989783; rs10637568; rs4148792; rs35973488; rs34781398; rs10690488; rs13390485; rs3770580; rs13383759; rs2892807; rs10699842; rs4148789; rs4000815; rs35032329; rs4408693; rs2685806; rs33998212; rs34589831; rs34691362; rs13004789; rs3084035; rs7606165; rs35154196; rs7570477; rs34059765; rs35977549; rs527150; rs10681889; rs34080185; rs35552243; rs35580713; rs35340526; rs5836217; rs10554578; rs4516393; rs2544365; rs34311278; rs10168093; rs35514442; rs36001889; rs3214428; rs4668113; rs2632378; rs2632371; rs34453330; rs35194008; rs13019923; rs13033087; rs34138939; rs13410266; rs28405534; rs35658999; rs35059993; rs4148786; rs11890781; rs34193789; rs35929467; rs28802954; rs35849398; rs13425860; rs36026125; rs4148796; rs28727965; rs28846465; rs13407637; rs28864721; rs3083997; rs35270920; rs35439431; rs10168165; rs17208900; rs10533401; rs2892808; rs34166812; rs1101532; rs3814383; rs13407824; rs35500066; rs35992163; rs34090697; rs34874425; rs34616346; rs10184740; rs10490134; rs10490135; rs10497346; rs10497347; rs11568356; rs11568358; rs11568359; rs11568360; rs11568363; rs11568364; rs11568366; rs11568371; rs11568373; rs11568374; rs11568376; rs11568379; rs11892211; rs11902639; rs12615867; rs13385351; rs13391933; rs13394065; rs13400268; rs13407094; rs13410081; rs13419326; rs1357170; rs16856185; rs16856187; rs16856196; rs16856207; rs16856209; rs16856406; rs2161037; rs2177075; rs2544368; rs2632376; rs4144857; rs4144858; rs4233823; rs475612; rs502570; rs504979; rs537183; rs563694; rs6433097; rs7577650

# Macromolecular_Interacting_Partner_2_General_References:
9806540; 11829140; 11815775

# Macromolecular_Interacting_Partner_2_References:
11179459; 11264982; 11557132; 12404239

# Macromolecular_Interacting_Partner_3_ID:
7546

# Macromolecular_Interacting_Partner_3_Name:
Prolactin precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
PRL

# Macromolecular_Interacting_Partner_3_Gene_Name:
PRL

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Prolactin precursor
MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN
EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG
LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
227

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
25876

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.99

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Prolactin acts primarily on the mammary gland by promoting lactation

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_3_Signals:
1-28

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
34211

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
PRL_HUMAN (P01236)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
PRL

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
PRL

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:9445

# Macromolecular_Interacting_Partner_3_PDB_ID:
1RW5

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>684 bp
ATGAACATCAAAGGATCGCCATGGAAAGGGTCCCTCCTGCTGCTGCTGGTGTCAAACCTG
CTGCTGTGCCAGAGCGTGGCCCCCTTGCCCATCTGTCCCGGCGGGGCTGCCCGATGCCAG
GTGACCCTTCGAGACCTGTTTGACCGCGCCGTCGTCCTGTCCCACTACATCCATAACCTC
TCCTCAGAAATGTTCAGCGAATTCGATAAACGGTATACCCATGGCCGGGGGTTCATTACC
AAGGCCATCAACAGCTGCCACACTTCTTCCCTTGCCACCCCCGAAGACAAGGAGCAAGCC
CAACAGATGAATCAAAAAGACTTTCTGAGCCTGATAGTCAGCATATTGCGATCCTGGAAT
GAGCCTCTGTATCATCTGGTCACGGAAGTACGTGGTATGCAAGAAGCCCCGGAGGCTATC
CTATCCAAAGCTGTAGAGATTGAGGAGCAAACCAAACGGCTTCTAGAGGGCATGGAGCTG
ATAGTCAGCCAGGTTCATCCTGAAACCAAAGAAAATGAGATCTACCCTGTCTGGTCGGGA
CTTCCATCCCTGCAGATGGCTGATGAAGAGTCTCGCCTTTCTGCTTATTATAACCTGCTC
CACTGCCTACGCAGGGATTCACATAAAATCGACAATTATCTCAAGCTCCTGAAGTGCCGA
ATCATCCACAACAACAACTGCTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
V00566

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_3_Locus:
6p22.2-p21.3

# Macromolecular_Interacting_Partner_3_SNPs:
Not Available

# Macromolecular_Interacting_Partner_3_General_References:
6260780; 6325171; 2050267; 6146607; 9266104; 925136; 1126929

# Macromolecular_Interacting_Partner_3_References:
11564677; 7945260

# Macromolecular_Interacting_Partner_4_ID:
7193

# Macromolecular_Interacting_Partner_4_Name:
Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide

# Macromolecular_Interacting_Partner_4_Synonyms:
GRPP; Oxyntomodulin; OXY; OXM; Glucagon; Glucagon-like peptide 1; GLP-1; Glucagon-like peptide 1(7-37; GLP-1(7-37; Glucagon-like peptide 1(7-36; GLP-1(7-36; Glucagon-like peptide 2; GLP-2]

# Macromolecular_Interacting_Partner_4_Gene_Name:
GCG

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Glucagon precursor Contains: Glicentin; Glicentinrelated polypeptide
MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTS
DYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFI
AWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMNTILDNLAARDFINWLIQTKITDRK


# Macromolecular_Interacting_Partner_4_Number_of_Residues:
180

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
20909

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.14

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00123:Hormone_2

# Macromolecular_Interacting_Partner_4_Signals:
1-20

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
183270

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
GLUC_HUMAN (P01275)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
GCG

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
GCG

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:4191

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>543 bp
ATGAAAAGCATTTACTTTGTGGCTGGGTTATTTGTAATGCTGGTACAAGGCAGCTGGCAA
CGTTCCCTTCAAGACACAGAGGAGAAATCCAGATCATTCTCAGCTTCCCAGGCAGACCCA
CTCAGTGATCCTGATCAGATGAACGAGGACAAGCGCCATTCACAGGGCACATTCACCAGT
GACTACAGCAAGTATCTGGACTCCAGGCGTGCCCAAGATTTTGTGCAGTGGTTGATGAAT
ACCAAGAGGAACAGGAATAACATTGCCAAACGTCACGATGAATTTGAGAGACATGCTGAA
GGGACCTTTACCAGTGATGTAAGTTCTTATTTGGAAGGCCAAGCTGCCAAGGAATTCATT
GCTTGGCTGGTGAAAGGCCGAGGAAGGCGAGATTTCCCAGAAGAGGTCGCCATTGTTGAA
GAACTTGGCCGCAGACATGCTGATGGTTCTTTCTCTGATGAGATGAACACCATTCTTGAT
AATCTTGCCGCCAGGGACTTTATAAACTGGTTGATTCAGACCAAAATCACTGACAGGAAA
TAA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
J04040

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_4_Locus:
2q36-q37

# Macromolecular_Interacting_Partner_4_SNPs:
rs5645; rs4664448; rs6732914; rs4664449; rs10490424; rs10164435; rs11897425; rs7581952; rs7569992; rs7559086; rs5649; rs4664447; rs5653; rs6727317; rs13306377; rs5647; rs5654; rs13306376; rs1990761; rs6717659; rs13001107; rs16846320; rs13416088; rs35424779; rs6717263; rs3811540; rs6717609; rs35328019; rs5650; rs11552334; rs35920035; rs11552338; rs1042405; rs11552330; rs11552335; rs34074912; rs11552339; rs17711059; rs11552332; rs16846334; rs11552331; rs11552336; rs35185096; rs35902561; rs35301560; rs10557377; rs10603613; rs5648; rs34801095; rs10671204; rs33949193; rs5652; rs5646; rs11378120; rs7569999; rs34405490; rs5651; rs11898004; rs35323923; rs13429709; rs10696486; rs34204135; rs35205044; rs3811539; rs7590067; rs11692314; rs17762054; rs41368446; rs34932341; rs10170813; rs10189636; rs11888030; rs13010545; rs13028221; rs2111487; rs2193494; rs2216338; rs2389680; rs2389681; rs3761656; rs4664450; rs6704722; rs6733736; rs7599142

# Macromolecular_Interacting_Partner_4_General_References:
2901414; 3725587; 6877358; 2753890; 8482423; 14557443; 14632334; 9287128; 12651102; 12554744; 12626323; 10605628; 9667960; 11943215; 12627948

# Macromolecular_Interacting_Partner_4_References:
15377289; 9724030

# Macromolecular_Interacting_Partner_5_ID:
7551

# Macromolecular_Interacting_Partner_5_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_5_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_5_Locus:
6p21.3

# Macromolecular_Interacting_Partner_5_SNPs:
Not Available

# Macromolecular_Interacting_Partner_5_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_5_References:
10613737

# Macromolecular_Interacting_Partner_6_ID:
7556

# Macromolecular_Interacting_Partner_6_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_6_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_6_Signals:
1-18

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_6_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_6_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_6_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_6_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_6_References:
11546646; 11682480; 8166281

# Macromolecular_Interacting_Partner_7_ID:
6198

# Macromolecular_Interacting_Partner_7_Name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase

# Macromolecular_Interacting_Partner_7_Synonyms:
HMG-CoA reductase

# Macromolecular_Interacting_Partner_7_Gene_Name:
HMGCR

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>3hydroxy3methylglutarylcoenzyme A reductase
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT
QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS
SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV
AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRAC
DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI
SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV
LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR
IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
888

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
97477

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.72

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  hydroxymethylglutaryl-CoA reductase (NADPH) activity
Function:  hydroxymethylglutaryl-CoA reductase (NADPH) activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  hydroxymethylglutaryl-CoA reductase (NADPH) activity
 ||
>>>
Process:  primary metabolism
Process:  lipid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  organelle membrane
Component:  endoplasmic reticulum membrane
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_7_General_Function:
Lipid transport and metabolism 

# Macromolecular_Interacting_Partner_7_Specific_Function:
This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis

# Macromolecular_Interacting_Partner_7_Pathway:
map00100  Biosynthesis of steroids

# Macromolecular_Interacting_Partner_7_Reaction:
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00368:HMG-CoA_red

# Macromolecular_Interacting_Partner_7_Signals:
1-23

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
EC 1.1.1.34

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
306865

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
HMDH_HUMAN (P04035)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
HMGCR

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
HMGCR

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:5006

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein. Peroxisome; peroxisomal membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>2667 bp
ATGTTGTCAAGACTTTTTCGAATGCATGGCCTCTTTGTGGCCTCCCATCCCTGGGAAGTC
ATAGTGGGGACAGTGACACTGACCATCTGCATGATGTCCATGAACATGTTTACTGGTAAC
AATAAGATCTGTGGTTGGAATTATGAATGTCCAAAGTTTGAAGAGGATGTTTTGAGCAGT
GACATTATAATTCTGACAATAACACGATGCATAGCCATCCTGTATATTTACTTCCAGTTC
CAGAATTTACGTCAACTTGGATCAAAATATATTTTGGGTATTGCTGGCCTTTTCACAATT
TTCTCAAGTTTTGTATTCAGTACAGTTGTCATTCACTTCTTAGACAAAGAATTGACAGGC
TTGAATGAAGCTTTGCCCTTTTTCCTACTTTTGATTGACCTTTCCAGAGCAAGCACATTA
GCAAAGTTTGCCCTCAGTTCCAACTCACAGGATGAAGTAAGGGAAAATATTGCTCGTGGA
ATGGCAATTTTAGGTCCTACGTTTACCCTCGATGCTCTTGTTGAATGTCTTGTGATTGGA
GTTGGTACCATGTCAGGGGTACGTCAGCTTGAAATTATGTGCTGCTTTGGCTGCATGTCA
GTTCTTGCCAACTACTTCGTGTTCATGACTTTCTTCCCAGCTTGTGTGTCCTTGGTATTA
GAGCTTTCTCGGGAAAGCCGCGAGGGTCGTCCAATTTGGCAGCTCAGCCATTTTGCCCGA
GTTTTAGAAGAAGAAGAAAATAAGCCGAATCCTGTAACTCAGAGGGTCAAGATGATTATG
TCTCTAGGCTTGGTTCTTGTTCATGCTCACAGTCGCTGGATAGCTGATCCTTCTCCTCAA
AACAGTACAGCAGATACTTCTAAGGTTTCATTAGGACTGGATGAAAATGTGTCCAAGAGA
ATTGAACCAAGTGTTTCCCTCTGGCAGTTTTATCTCTCTAAAATGATCAGCATGGATATT
GAACAAGTTATTACCCTAAGTTTAGCTCTCCTTCTGGCTGTCAAGTACATCTTCTTTGAA
CAAACAGAGACAGAATCTACACTCTCATTAAAAAACCCTATCACATCTCCTGTAGTGACA
CAAAAGAAAGTCCCAGACAATTGTTGTAGACGTGAACCTATGCTGGTCAGAAATAACCAG
AAATGTGATTCAGTAGAGGAAGAGACAGGGATAAACCGAGAAAGAAAAGTTGAGGTTATA
AAACCCTTAGTGGCTGAAACAGATACCCCAAACAGAGCTACATTTGTGGTTGGTAACTCC
TCCTTACTCGATACTTCATCAGTACTGGTGACACAGGAACCTGAAATTGAACTTCCCAGG
GAACCTCGGCCTAATGAAGAATGTCTACAGATACTTGGGAATGCAGAGAAAGGTGCAAAA
TTCCTTAGTGATGCTGAGATCATCCAGTTAGTCAATGCTAAGCATATCCCAGCCTACAAG
TTGGAAACTCTGATGGAAACTCATGAGCGTGGTGTATCTATTCGCCGACAGTTACTTTCC
AAGAAGCTTTCAGAACCTTCTTCTCTCCAGTACCTACCTTACAGGGATTATAATTACTCC
TTGGTGATGGGAGCTTGTTGTGAGAATGTTATTGGATATATGCCCATCCCTGTTGGAGTG
GCAGGACCCCTTTGCTTAGATGAAAAAGAATTTCAGGTTCCAATGGCAACAACAGAAGGT
TGTCTTGTGGCCAGCACCAATAGAGGCTGCAGAGCAATAGGTCTTGGTGGAGGTGCCAGC
AGCCGAGTCCTTGCAGATGGGATGACTCGTGGCCCAGTTGTGCGTCTTCCACGTGCTTGT
GACTCTGCAGAAGTGAAAGCCTGGCTCGAAACATCTGAAGGGTTCGCAGTGATAAAGGAG
GCATTTGACAGCACTAGCAGATTTGCACGTCTACAGAAACTTCATACAAGTATAGCTGGA
CGCAACCTTTATATCCGTTTCCAGTCCAGGTCAGGGGATGCCATGGGGATGAACATGATT
TCAAAGGGTACAGAGAAAGCACTTTCAAAACTTCACGAGTATTTCCCTGAAATGCAGATT
CTAGCCGTTAGTGGTAACTATTGTACTGACAAGAAACCTGCTGCTATAAATTGGATAGAG
GGAAGAGGAAAATCTGTTGTTTGTGAAGCTGTCATTCCAGCCAAGGTTGTCAGAGAAGTA
TTAAAGACTACCACAGAGGCTATGATTGAGGTCAACATTAACAAGAATTTAGTGGGCTCT
GCCATGGCTGGGAGCATAGGAGGCTACAACGCCCATGCAGCAAACATTGTCACCGCCATC
TACATTGCCTGTGGACAGGATGCAGCACAGAATGTTGGTAGTTCAAACTGTATTACTTTA
ATGGAAGCAAGTGGTCCCACAAATGAAGATTTATATATCAGCTGCACCATGCCATCTATA
GAGATAGGAACGGTGGGTGGTGGGACCAACCTACTACCTCAGCAAGCCTGTTTGCAGATG
CTAGGTGTTCAAGGAGCATGCAAAGATAATCCTGGGGAAAATGCCCGGCAGCTTGCCCGA
ATTGTGTGTGGGACCGTAATGGCTGGGGAATTGTCACTTATGGCAGCATTGGCAGCAGGA
CATCTTGTCAAAAGTCACATGATTCACAACAGGTCGAAGATCAATTTACAAGACCTCCAA
GGAGCTTGCACCAAGAAGACAGCCTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
M11058

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_7_Locus:
5q13.3-q14

# Macromolecular_Interacting_Partner_7_SNPs:
rs5908; rs10038095; rs12916; rs10045497; rs5909; rs17883498; rs17244932; rs17238554; rs17238379; rs17244771; rs17238372; rs17244764; rs17238393; rs17244757; rs17244743; rs17244778; rs6805; rs10474435; rs2241402; rs2878419; rs3846662; rs3846661; rs10942735; rs3846663; rs6453131; rs6882842; rs17244855; rs12654264; rs7717396; rs17244841; rs17244806; rs17238596; rs17238540; rs17244862; rs10473972; rs10474434; rs17244890; rs11742194; rs10515198; rs17238477; rs17244848; rs17244883; rs17238449; rs17244834; rs2303152; rs17244813; rs17238484; rs3064877; rs11957984; rs10053643; rs17238435; rs2303151; rs17238456; rs17238603; rs35767444; rs17238575; rs17238589; rs17244897; rs17244827; rs10063134; rs35635349; rs3843482; rs17238519; rs17238498; rs17244792; rs17244799; rs17244960; rs17244785; rs17238442; rs17244876; rs4629571; rs3761739; rs17244953; rs17238337; rs17238330; rs17244708; rs3761738; rs3761740; rs17244946; rs17244715; rs34652146; rs34334938; rs35436905; rs35561739; rs36010179; rs1044453; rs11402730; rs35855355; rs34198674; rs11453557; rs12657545; rs35306582; rs10683134; rs11379632; rs17648121; rs33988510; rs11443896; rs10590407; rs2898551; rs3064191; rs35744174; rs35152895; rs35491024; rs33926107; rs13436857; rs11743717; rs11749783; rs11957619; rs16872521; rs16872523; rs3180743; rs35176659; rs3733907; rs3761741; rs3843480; rs3843481; rs3931914; rs4703670; rs4704209; rs7703051

# Macromolecular_Interacting_Partner_7_General_References:
2991281; 10698924; 10391209

# Macromolecular_Interacting_Partner_7_References:
7835596; 7843727; 7986821; 8612995

# Macromolecular_Interacting_Partner_8_ID:
7569

# Macromolecular_Interacting_Partner_8_Name:
Interleukin-6 precursor

# Macromolecular_Interacting_Partner_8_Synonyms:
IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF

# Macromolecular_Interacting_Partner_8_Gene_Name:
IL6

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Interleukin6 precursor
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYI
LDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLL
EFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQ
AQNQWLQDMTTHLILRSFKEFLQSSLRALRQM

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
212

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
23718

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
6.52

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interleukin-6 receptor binding
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
IL-6 is a cytokine with a wide variety of biological functions:it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00489:IL6

# Macromolecular_Interacting_Partner_8_Signals:
1-29

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
32674

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
IL6_HUMAN (P05231)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
IL6

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
IL6

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:6018

# Macromolecular_Interacting_Partner_8_PDB_ID:
2IL6

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>639 bp
ATGAACTCCTTCTCCACAAGCGCCTTCGGTCCAGTTGCCTTCTCCCTGGGGCTGCTCCTG
GTGTTGCCTGCTGCCTTCCCTGCCCCAGTACCCCCAGGAGAAGATTCCAAAGATGTAGCC
GCCCCACACAGACAGCCACTCACCTCTTCAGAACGAATTGACAAACAAATTCGGTACATC
CTCGACGGCATCTCAGCCCTGAGAAAGGAGACATGTAACAAGAGTAACATGTGTGAAAGC
AGCAAAGAGGCACTGGCAGAAAACAACCTGAACCTTCCAAAGATGGCTGAAAAAGATGGA
TGCTTCCAATCTGGATTCAATGAGGAGACTTGCCTGGTGAAAATCATCACTGGTCTTTTG
GAGTTTGAGGTATACCTAGAGTACCTCCAGAACAGATTTGAGAGTAGTGAGGAACAAGCC
AGAGCTGTCCAGATGAGTACAAAAGTCCTGATCCAGTTCCTGCAGAAAAAGGCAAAGAAT
CTAGATGCAATAACCACCCCTGACCCAACCACAAATGCCAGCCTGCTGACGAAGCTGCAG
GCACAGAACCAGTGGCTGCAGGACATGACAACTCATCTCATTCTGCGCAGCTTTAAGGAG
TTCCTGCAGTCCAGCCTGAGGGCTCTTCGGCAAATGTAG

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
X04430

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_8_Locus:
7p21

# Macromolecular_Interacting_Partner_8_SNPs:
rs2069860; rs13306435; rs2069830; rs2069849; rs2069850; rs2069851; rs13306436; rs2069857; rs3087226; rs1474347; rs2069833; rs2069832; rs1554606; rs2069842; rs1548216; rs2069840; rs2066992; rs1474348; rs2069835; rs2069831; rs2069845; rs2069838; rs2069834; rs2069837; rs1524107; rs2069841; rs3087232; rs13306433; rs34277345; rs2069847; rs3087227; rs2069848; rs35361244; rs34249410; rs3087228; rs3087233; rs3087230; rs2069843; rs3087229; rs2069844; rs3087231; rs2069858; rs1800795; rs2069824; rs1800797; rs7802308; rs1800796; rs7802307; rs2069829; rs3087223; rs2069827; rs2069825; rs3087225; rs2069861; rs36215814; rs2234683; rs2069828; rs11544633; rs41477054; rs13306438; rs3915892; rs3915893; rs2069839; rs13306434; rs3087234; rs2069846; rs2069836; rs3087235; rs2069859; rs13447445; rs36215459; rs36215820; rs35081782; rs35178191; rs13447446; rs2069826; rs34328912; rs3087224; rs36215821; rs4335044; rs36215822; rs11973115; rs36215817; rs11445458; rs34224237; rs36215461; rs36215818; rs34280821; rs34012176; rs34709428; rs10242595; rs10499563; rs11766273; rs12700386; rs12700390; rs13438415; rs1546762; rs1546763; rs17147230; rs1880241; rs1880242; rs1880243; rs2069852; rs2069853; rs2069854; rs2069855; rs2069862; rs3087221; rs3087238; rs35610689; rs4398801; rs4719713; rs4719714; rs6461662; rs6946908; rs6963444; rs6963591; rs7458109; rs7784987; rs7801617; rs7805828; rs940367

# Macromolecular_Interacting_Partner_8_General_References:
3491322; 3500852; 3538015; 3023045; 3320204; 2789513; 3758081; 3266463; 1291290; 3279116; 2610854; 1883960; 7851440; 2472117; 2037043; 8555185; 9159484; 9118960

# Macromolecular_Interacting_Partner_8_References:
10947163; 7810656

# Macromolecular_Interacting_Partner_9_ID:
7574

# Macromolecular_Interacting_Partner_9_Name:
Cholecystokinins precursor

# Macromolecular_Interacting_Partner_9_Synonyms:
CCK[Contains: Cholecystokinin 58; CCK58; Cholecystokinin 39; CCK39; Cholecystokinin 33; CCK33; Cholecystokinin 12; CCK12; Cholecystokinin 8; CCK8]

# Macromolecular_Interacting_Partner_9_Gene_Name:
CCK

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Cholecystokinins precursor
MNSGVCLCVLMAVLAAGALTQPVPPADPAGSGLQRAEEAPRRQLRVSQRTDGESRAHLGA
LLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDFGRRSAEEYEYPS

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
115

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
12670

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
9.22

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00918:Gastrin

# Macromolecular_Interacting_Partner_9_Signals:
1-20

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
179996

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
CCKN_HUMAN (P06307)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
CCK

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
CCK

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:1569

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>348 bp
ATGAACAGCGGCGTGTGCCTGTGCGTGCTGATGGCGGTACTGGCGGCTGGCGCCCTGACG
CAGCCGGTGCCTCCCGCAGATCCCGCGGGCTCCGGGCTGCAGCGGGCAGAGGAGGCGCCC
CGTAGGCAGCTGAGGGTATCGCAGAGAACGGATGGCGAGTCCCGAGCGCACCTGGGCGCC
CTGCTGGCAAGATACATCCAGCAGGCCCGGAAAGCTCCTTCTGGACGAATGTCCATCGTT
AAGAACCTGCAGAACCTGGACCCCAGCCACAGGATAAGTGACCGGGACTACATGGGCTGG
ATGGATTTTGGCCGTCGCAGTGCCGAGGAGTATGAGTACCCCTCCTAG

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
L00354

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_9_Locus:
3p22-p21.3

# Macromolecular_Interacting_Partner_9_SNPs:
rs3774395; rs754635; rs747456; rs1799923; rs747455; rs8192473; rs2241996; rs6784327; rs6762874; rs11571844; rs2241997; rs11571876; rs11571846; rs11571843; rs11571847; rs1868522; rs4377469; rs8192472; rs10865918; rs2278794; rs4602358; rs11129949; rs11571857; rs11571855; rs11571851; rs3774396; rs11571864; rs11571866; rs11571863; rs11571875; rs7616571; rs11571867; rs11571871; rs11571856; rs11571849; rs11571853; rs10865917; rs11129948; rs11571877; rs11571888; rs11571878; rs11571842; rs11571884; rs11571887; rs11571882; rs11571880; rs11571841; rs3806691; rs11571838; rs11571879; rs11571848; rs11559016; rs1050815; rs11571845; rs3774394; rs11328368; rs4634088; rs34621311; rs11571859; rs11298401; rs11345711; rs11571873; rs11571862; rs4266164; rs11571865; rs11571852; rs11571860; rs11571858; rs11571872; rs11571869; rs11571854; rs11571874; rs11571861; rs35155419; rs7371919; rs11571870; rs11571868; rs11571881; rs11571886; rs34853186; rs11571839; rs11571840; rs11571883; rs35292864; rs11571885; rs10460960; rs11129946; rs11129947; rs11129950; rs12493571; rs13069836; rs17071699; rs17071704; rs17071771; rs1867020; rs1868520; rs1868521; rs2029127; rs4450782; rs4488805; rs4533619; rs6605331; rs6786615; rs7615049; rs7621531; rs7628785; rs7628795; rs9311317; rs935111; rs935112; rs9682785; rs9757702; rs9813346; rs9835027

# Macromolecular_Interacting_Partner_9_General_References:
3856870; 11076522

# Macromolecular_Interacting_Partner_9_References:
7678329; 9013282; 9712181

# Macromolecular_Interacting_Partner_10_ID:
7592

# Macromolecular_Interacting_Partner_10_Name:
Secretin precursor

# Macromolecular_Interacting_Partner_10_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_10_Gene_Name:
SCT

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Secretin precursor
MAPRPLLLLLLLLGGSAARPAPPRARRHSDGTFTSELSRLREGARLQRLLQGLVGKRSEQ
DAENSMAWTRLSAGLLCPSGSNMPILQAWMPLDGTWSPWLPPGPMVSEPAGAAAEGTLRP
R

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
121

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
13016

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
11.78

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00123:Hormone_2

# Macromolecular_Interacting_Partner_10_Signals:
1-18

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
11138667

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
SECR_HUMAN (P09683)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
SCT

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
SCT

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:10607

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>366 bp
ATGGCCCCCCGGCCCCTCCTGCTGCTGCTGCTGCTCCTCGGGGGCTCCGCCGCGCGCCCC
GCGCCCCCCAGGGCCCGGCGACACTCAGACGGGACGTTCACCAGCGAGCTCAGCCGCCTG
CGGGAGGGCGCGCGGCTCCAGCGGCTGCTACAGGGCCTGGTGGGGAAGCGCAGCGAGCAG
GACGCAGAGAACAGCATGGCCTGGACCAGGCTCAGCGCGGGTCTGCTCTGCCCGTCAGGG
TCCAACATGCCCATCCTGCAGGCCTGGATGCCCCTGGACGGGACCTGGTCTCCCTGGCTG
CCCCCTGGGCCTATGGTTTCAGAACCAGCTGGCGCTGCTGCAGAAGGAACCTTGCGGCCC
AGATGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
AF244355

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_10_Locus:
11p15.5

# Macromolecular_Interacting_Partner_10_SNPs:
Not Available

# Macromolecular_Interacting_Partner_10_General_References:
11060443

# Macromolecular_Interacting_Partner_10_References:
12360484; 16440368

# Macromolecular_Interacting_Partner_11_ID:
5331

# Macromolecular_Interacting_Partner_11_Name:
Alkaline phosphatase, placental-like precursor

# Macromolecular_Interacting_Partner_11_Synonyms:
Alkaline phosphatase Nagao isozyme; Germ-cell alkaline phosphatase; GCAP; PLAP-like; ALP-1

# Macromolecular_Interacting_Partner_11_Gene_Name:
ALPPL2

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Alkaline phosphatase, placentallike precursor
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLG
DGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLC
GVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDY
SQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRD
STLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERA
GQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL
KDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHV
MAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
532

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
57378

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
6.31

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_11_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_11_Specific_Function:
A phosphate monoester + H(2)O = an alcohol + phosphate

# Macromolecular_Interacting_Partner_11_Pathway:
map00361  gamma-Hexachlorocyclohexane degradation;
 map00790  Folate biosynthesis

# Macromolecular_Interacting_Partner_11_Reaction:
A phosphate monoester + H2O = an alcohol + phosphate

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF00245:Alk_phosphatase

# Macromolecular_Interacting_Partner_11_Signals:
1-19

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
EC 3.1.3.1

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
178428

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
PPBN_HUMAN (P10696)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
ALPPL2

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
ALPPL2

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:441

# Macromolecular_Interacting_Partner_11_PDB_ID:
1EW2

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>1599 bp
ATGCAGGGGCCCTGGGTGCTGCTCCTGCTGGGCCTGAGGCTACAGCTCTCCCTGGGCATC
ATCCCAGTTGAGGAGGAGAACCCGGACTTCTGGAACCGCCAGGCAGCCGAGGCCCTGGGT
GCCGCCAAGAAGCTGCAGCCTGCACAGACAGCCGCCAAGAACCTCATCATGTTCCTGGGT
GACGGGATGGGGGTGTCTACGGTGACAGCTGCCAGGATCCTAAAAGGGCAGAAGAAGGAC
AAACTGGGGCCTGAGACCTTCCTGGCCATGGACCGCTTCCCGTACGTGGCTCTGTCCAAG
ACATACAGTGTAGACAAGCATGTGCCAGACAGTGGAGCCACAGCCACGGCCTACCTGTGC
GGGGTCAAGGGCAACTTCCAGACCATTGGCTTGAGTGCAGCCGCCCGCTTTAACCAGTGC
AACACGACACGCGGCAACGAGGTCATCTCCGTGGTGAATCGGGCCAAGAAAGCAGGAAAG
TCAGTGGGAGTGGTAACCACCACACGGGTGCAGCATGCCTCGCCAGCCGGCACCTACGCC
CACACGGTGAACCGCAACTGGTACTCGGATGCCGACGTGCCTGCCTCGGCCCGCCAGGAG
GGGTGCCAGGACATCGCCACGCAGCTCATCTCCAACATGGACATTGATGTGATCCTAGGT
GGAGGCCGAAAGTACATGTTTCCCATGGGGACCCCAGACCCTGAGTACCCAGATGACTAC
AGCCAAGGTGGGACCAGGCTGGACGGGAAGAATCTGGTGCAGGAATGGCTGGCGAAGCAC
CAGGGTGCCCGGTACGTGTGGAACCGCACTGAGCTCCTGCAGGCTTCCCTGGACCCGTCT
GTGACCCATCTCATGGGTCTCTTTGAGCCTGGAGACATGAAATACGAGATCCACCGAGAC
TCCACACTGGACCCCTCCCTGATGGAGATGACAGAGGCTGCCCTGCTCCTGCTGAGCAGG
AACCCCCGCGGCTTCTTCCTCTTCGTGGAGGGTGGTCGCATCGACCATGGTCATCATGAA
AGCAGGGCTTACCGGGCACTGACTGAGACGATCATGTTCGACGACGCCATTGAGAGGGCG
GGCCAGCTCACCAGCGAGGAGGACACGCTGAGCCTCGTCACTGCCGACCACTCCCACGTC
TTCTCCTTCGGAGGCTACCCCCTGCGAGGGAGCTCCATCTTCGGGCTGGCCCCTGGCAAG
GCCCGGGACAGGAAGGCCTACACGGTCCTCCTATACGGAAACGGTCCAGGCTATGTGCTC
AAGGACGGCGCCCGGCCGGATGTTACGGAGAGCGAGAGCGGGAGCCCCGAGTATCGGCAG
CAGTCAGCAGTGCCCCTGGACGGAGAGACCCACGCAGGCGAGGACGTGGCGGTGTTCGCG
CGCGGCCCGCAGGCGCACCTGGTTCACGGCGTGCAGGAGCAGACCTTCATAGCGCACGTC
ATGGCCTTCGCCGCCTGCCTGGAGCCCTACACCGCCTGCGACCTGGCGCCCCCCGCCGGC
ACCACCGACGCCGCGCACCCGGGGCCGTCCGTGGTCCCCGCGTTGCTTCCTCTGCTGGCA
GGGACCTTGCTGCTGCTGGGGACGGCCACTGCTCCCTGA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
J03252

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_11_Locus:
2q37

# Macromolecular_Interacting_Partner_11_SNPs:
rs1048983; rs1048999; rs17416141; rs2090543; rs1048997; rs1009934; rs2678519; rs2697781; rs3828248; rs3828254; rs2697767; rs3828249; rs2697768; rs1048995; rs16836187; rs3116148; rs1130334; rs41265119; rs41265117; rs3111340; rs41265115; rs1049002; rs1049001; rs3189080; rs3924351; rs1049003; rs1130348; rs1130351; rs3924352; rs3189077; rs6728119; rs2091555; rs2945420; rs2678518; rs41265113; rs3111339; rs3833560; rs2678517; rs2945421; rs41265111; rs2091556; rs3830644; rs3828251; rs3828253; rs2697769; rs11363206; rs3828250; rs3828252; rs11678251; rs1001868; rs10195918; rs13002718; rs13003189; rs13412526; rs1878691; rs2082841; rs2082842; rs2139026; rs2139027; rs2573208; rs2573209; rs2697766; rs2697790; rs2697791; rs2697792; rs2697793; rs2741321; rs2853380; rs732581; rs744873; rs744874; rs790050; rs790051

# Macromolecular_Interacting_Partner_11_General_References:
2834730; 2745460; 2297757; 2162249; 3387245

# Macromolecular_Interacting_Partner_11_References:
7488238; 7560859; 8099310

# Macromolecular_Interacting_Partner_12_ID:
5749

# Macromolecular_Interacting_Partner_12_Name:
Cytochrome P450 7A1

# Macromolecular_Interacting_Partner_12_Synonyms:
Cholesterol 7-alpha-monooxygenase; CYPVII; Cholesterol 7-alpha-hydroxylase

# Macromolecular_Interacting_Partner_12_Gene_Name:
CYP7A1

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Cytochrome P450 7A1
MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQ
RKHGHVFTCK
LMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDG
NTTENINDTFIKTLQGHALNS
LTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRV
MFEAGYLTIFGRDLTRRDTQKAHILNNLDNFK
QFDKVFPALVAGLPIHMFRTAHNAREK
LAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHL
VVLWASQANTIPATFW
SLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSII
KESLR
LSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDE
NGKTK
TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQA
KCPPLDQSRAGLGILP
PLNDIEFKYKFKHL

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
504

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
57661

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
8.34

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_12_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Macromolecular_Interacting_Partner_12_Specific_Function:
Cholesterol + NADPH + O(2) = 7-alpha- hydroxycholesterol + NADP(+) + H(2)O

# Macromolecular_Interacting_Partner_12_Pathway:
map00120  Bile acid biosynthesis

# Macromolecular_Interacting_Partner_12_Reaction:
cholesterol + NADPH + H+ + O2 = 7alpha-hydroxycholesterol + NADP+ + H2O

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF00067:p450

# Macromolecular_Interacting_Partner_12_Signals:
1-23

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
EC 1.14.13.17

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
23909

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
CP7A1_HUMAN (P22680)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
CYP7A1

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
CYP7A1

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:2651

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>1515 bp

ATGATGACCACATCTTTGATTTGGGGGATTGCTATAGCAGCATGCTGTTGTCTATGGCT
TATTCTTGGAA
TTAGGAGAAGGCAAACGGGTGAACCACCTCTAGAGAATGGATTAATTC
CATACCTGGGCTGTGCTCTGCA
ATTTGGTGCCAATCCTCTTGAGTTCCTCAGAGCAAAT
CAAAGGAAACATGGTCATGTTTTTACCTGCAAA
CTAATGGGAAAATATGTCCATTTCAT
CACAAATCCCTTGTCATACCATAAGGTGTTGTGCCACGGAAAAT
ATTTTGATTGGAAAA
AATTTCACTTTGCTACTTCTGCGAAGGCATTTGGGCACAGAAGCATTGACCCGAT
GGAT
GGAAATACCACTGAAAACATAAACGACACTTTCATCAAAACCCTGCAGGGCCATGCCTTG
AATTCC
CTCACGGAAAGCATGATGGAAAACCTCCAACGTATCATGAGACCTCCAGTCTC
CTCTAACTCAAAGACCG
CTGCCTGGGTGACAGAAGGGATGTATTCTTTCTGCTACCGAG
TGATGTTTGAAGCTGGGTATTTAACTAT
CTTTGGCAGAGATCTTACAAGGCGGGACACA
CAGAAAGCACATATTCTAAACAATCTTGACAACTTCAAG
CAATTCGACAAAGTCTTTCC
AGCCCTGGTAGCAGGCCTCCCCATTCACATGTTCAGGACTGCGCACAATG
CCCGGGAGA
AACTGGCAGAGAGCTTGAGGCACGAGAACCTCCAAAAGAGGGAAAGCATCTCAGAACTGA
T
CAGCCTGCGCATGTTTCTCAATGACACTTTGTCCACCTTTGATGATCTGGAGAAGGCC
AAGACACACCTC
GTGGTCCTCTGGGCATCGCAAGCAAACACCATTCCAGCGACTTTCTG
GAGTTTATTTCAAATGATTAGGA
ACCCAGAAGCAATGAAAGCAGCTACTGAAGAAGTGA
AAAGAACATTAGAGAATGCTGGTCAAAAAGTCAG
CTTGGAAGGCAATCCTATTTGTTTG
AGTCAAGCAGAACTGAATGACCTGCCAGTATTAAATAGTATAATC
AAGGAATCGCTGAG
GCTTTCCAGTGCCTCCCTCAACATCCGGACAGCTAAGGAGGATTTCACTTTGCACC
TTG
AGGACGGTTCCTACAACATCCGAAAAGATAGCATCATAGCTCTTTACCCACAGTTAATGC
ACTTAGA
TCCAGAAATCTACCCAGACCCTTTGACTTTTAAATATGATAGGTATCTTGAT
GAAAACGGGAAGACAAAG
ACTACCTTCTATTGTAATGGACTCAAGTTAAAGTATTACTA
CATGCCCTTTGGATCGGGAGCTACAATAT
GTCCTGGAAGATTGTTCGCTATCCACGAAA
TCAAGCAATTTTTGATTCTGATGCTTTCTTATTTTGAATT
GGAGCTTATAGAGGGCCAA
GCTAAATGTCCACCTTTGGACCAGTCCCGGGCAGGCTTGGGCATTTTGCCG
CCATTGAA
TGATATTGAATTTAAATATAAATTCAAGCATTTGTGA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
X56088

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_12_Locus:
Not Available

# Macromolecular_Interacting_Partner_12_SNPs:
Not Available

# Macromolecular_Interacting_Partner_12_General_References:
8439551; 2384150; 1610352; 8020987; 1312351; 12721789

# Macromolecular_Interacting_Partner_12_References:
7666012; 7735245; 7835596; 7843727

# Macromolecular_Interacting_Partner_13_ID:
6988

# Macromolecular_Interacting_Partner_13_Name:
Canalicular multispecific organic anion transporter 1

# Macromolecular_Interacting_Partner_13_Synonyms:
ATP-binding cassette sub-family C member 2; Multidrug resistance-associated protein 2; Canalicular multidrug resistance protein

# Macromolecular_Interacting_Partner_13_Gene_Name:
ABCC2

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Canalicular multispecific organic anion transporter 1
MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSS
TTKLYLAKQVFVGFLLILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLVLLIQYS
RQWCVQKNSWFLSLFWILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILI
FSAFSENNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVS
KFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSG
TKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIG
YLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGET
VNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAIL
STKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFS
QLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMI
SSMLQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLD
IMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNIL
FGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLD
IYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIV
EKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAAS
ITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETG
KVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQR
DMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRI
VNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMF
YVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSW
ITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTS
EIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGI
TCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTII
PQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIG
QRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMD
SDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIENVNSTKF

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
1545

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
174194

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
8.46

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
Function:  transporter activity
Function:  ATPase activity
Function:  hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Function:  ATPase activity, coupled to transmembrane movement of substances
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_13_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_13_Specific_Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF00664:ABC_membrane;
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_13_Signals:
None

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
28-48
69-89
94-114
127-147
166-186
314-334
361-381
438-458
462-482
545-565
588-608
972-992
1034-1054
1098-1118
1120-1140
1212-1232
1235-1255

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
1764162

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
MRP2_HUMAN (Q92887)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
ABCC2

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
ABCC2

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:53

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>4638 bp
ATGCTGGAGAAGTTCTGCAACTCTACTTTTTGGAATTCCTCATTCCTGGACAGTCCGGAG
GCAGACCTGCCACTTTGTTTTGAGCAAACTGTTCTGGTGTGGATTCCCTTGGGCTTCCTA
TGGCTCCTGGCCCCCTGGCAGCTTCTCCACGTGTATAAATCCAGGACCAAGAGATCCTCT
ACCACCAAACTCTATCTTGCTAAGCAGGTATTCGTTGGTTTTCTTCTTATTCTAGCAGCC
ATAGAGCTGGCCCTTGTACTCACAGAAGACTCTGGACAAGCCACAGTCCCTGCTGTTCGA
TATACCAATCCAAGCCTCTACCTAGGCACATGGCTCCTGGTTTTGCTGATCCAATACAGC
AGACAATGGTGTGTACAGAAAAACTCCTGGTTCCTGTCCCTATTCTGGATTCTCTCGATA
CTCTGTGGCACTTTCCAATTTCAGACTCTGATCCGGACACTCTTACAGGGTGACAATTCT
AATCTAGCCTACTCCTGCCTGTTCTTCATCTCCTACGGATTCCAGATCCTGATCCTGATC
TTTTCAGCATTTTCAGAAAATAATGAGTCATCAAATAATCCATCATCCATAGCTTCATTC
CTGAGTAGCATTACCTACAGCTGGTATGACAGCATCATTCTGAAAGGCTACAAGCGTCCT
CTGACACTCGAGGATGTCTGGGAAGTTGATGAAGAGATGAAAACCAAGACATTAGTGAGC
AAGTTTGAAACGCACATGAAGAGAGAGCTGCAGAAAGCCAGGCGGGCACTCCAGAGACGG
CAGGAGAAGAGCTCCCAGCAGAACTCTGGAGCCAGGCTGCCTGGCTTGAACAAGAATCAG
AGTCAAAGCCAAGATGCCCTTGTCCTGGAAGATGTTGAAAAGAAAAAAAAGAAGTCTGGG
ACCAAAAAAGATGTTCCAAAATCCTGGTTGATGAAGGCTCTGTTCAAAACTTTCTACATG
GTGCTCCTGAAATCATTCCTACTGAAGCTAGTGAATGACATCTTCACGTTTGTGAGTCCT
CAGCTGCTGAAATTGCTGATCTCCTTTGCAAGTGACCGTGACACATATTTGTGGATTGGA
TATCTCTGTGCAATCCTCTTATTCACTGCGGCTCTCATTCAGTCTTTCTGCCTTCAGTGT
TATTTCCAACTGTGCTTCAAGCTGGGTGTAAAAGTACGGACAGCTATCATGGCTTCTGTA
TATAAGAAGGCATTGACCCTATCCAACTTGGCCAGGAAGGAGTACACCGTTGGAGAAACA
GTGAACCTGATGTCTGTGGATGCCCAGAAGCTCATGGATGTGACCAACTTCATGCACATG
CTGTGGTCAAGTGTTCTACAGATTGTCTTATCTATCTTCTTCCTATGGAGAGAGTTGGGA
CCCTCAGTCTTAGCAGGTGTTGGGGTGATGGTGCTTGTAATCCCAATTAATGCGATACTG
TCCACCAAGAGTAAGACCATTCAGGTCAAAAATATGAAGAATAAAGACAAACGTTTAAAG
ATCATGAATGAGATTCTTAGTGGAATCAAGATCCTGAAATATTTTGCCTGGGAACCTTCA
TTCAGAGACCAAGTACAAAACCTCCGGAAGAAAGAGCTCAAGAACCTGCTGGCCTTTAGT
CAACTACAGTGTGTAGTAATATTCGTCTTCCAGTTAACTCCAGTCCTGGTATCTGTGGTC
ACATTTTCTGTTTATGTCCTGGTGGATAGCAACAATATTTTGGATGCACAAAAGGCCTTC
ACCTCCATTACCCTCTTCAATATCCTGCGCTTTCCCCTGAGCATGCTTCCCATGATGATC
TCCTCCATGCTCCAGGCCAGTGTTTCCACAGAGCGGCTAGAGAAGTACTTGGGAGGGGAT
GACTTGGACACATCTGCCATTCGACATGACTGCAATTTTGACAAAGCCATGCAGTTTTCT
GAGGCCTCCTTTACCTGGGAACATGATTCGGAAGCCACAGTCCGAGATGTGAACCTGGAC
ATTATGGCAGGCCAACTTGTGGCTGTGATAGGCCCTGTCGGCTCTGGGAAATCCTCCTTG
ATATCAGCCATGCTGGGAGAAATGGAAAATGTCCACGGGCACATCACCATCAAGGGCACC
ACTGCCTATGTCCCACAGCAGTCCTGGATTCAGAATGGCACCATAAAGGACAACATCCTT
TTTGGAACAGAGTTTAATGAAAAGAGGTACCAGCAAGTACTGGAGGCCTGTGCTCTCCTC
CCAGACTTGGAAATGCTGCCTGGAGGAGATTTGGCTGAGATTGGAGAGAAGGGTATAAAT
CTTAGTGGGGGTCAGAAGCAGCGGATCAGCCTGGCCAGAGCTACCTACCAAAATTTAGAC
ATCTATCTTCTAGATGACCCCCTGTCTGCAGTGGATGCTCATGTAGGAAAACATATTTTT
AATAAGGTCTTGGGCCCCAATGGCCTGTTGAAAGGCAAGACTCGACTCTTGGTTACACAT
AGCATGCACTTTCTTCCTCAAGTGGATGAGATTGTAGTTCTGGGGAATGGAACAATTGTA
GAGAAAGGATCCTACAGTGCTCTCCTGGCCAAAAAAGGAGAGTTTGCTAAGAATCTGAAG
ACATTTCTAAGACATACAGGCCCTGAAGAGGAAGCCACAGTCCATGATGGCAGTGAAGAA
GAAGACGATGACTATGGGCTGATATCCAGTGTGGAAGAGATCCCCGAAGATGCAGCCTCC
ATAACCATGAGAAGAGAGAACAGCTTTCGTCGAACACTTAGCCGCAGTTCTAGGTCCAAT
GGCAGGCATCTGAAGTCCCTGAGAAACTCCTTGAAAACTCGGAATGTGAATAGCCTGAAG
GAAGACGAAGAACTAGTGAAAGGACAAAAACTAATTAAGAAGGAATTCATAGAAACTGGA
AAGGTGAAGTTCTCCATCTACCTGGAGTACCTACAAGCAATAGGATTGTTTTCGATATTC
TTCATCATCCTTGCGTTTGTGATGAATTCTGTGGCTTTTATTGGATCCAACCTCTGGCTC
AGTGCTTGGACCAGTGACTCTAAAATCTTCAATAGCACCGACTATCCAGCATCTCAGAGG
GACATGAGAGTTGGAGTCTACGGAGCTCTGGGATTAGCCCAAGGTATATTTGTGTTCATA
GCACATTTCTGGAGTGCCTTTGGTTTCGTCCATGCATCAAATATCTTGCACAAGCAACTG
CTGAACAATATCCTTCGAGCACCTATGAGATTTTTTGACACAACACCCACAGGCCGGATT
GTGAACAGGTTTGCCGGCGATATTTCCACAGTGGATGACACCCTGCCTCAGTCCTTGCGC
AGCTGGATTACATGCTTCCTGGGGATAATCAGCACCCTTGTCATGATCTGCATGGCCACT
CCTGTCTTCACCATCATCGTCATTCCTCTTGGCATTATTTATGTATCTGTTCAGATGTTT
TATGTGTCTACCTCCCGCCAGCTGAGGCGTCTGGACTCTGTCACCAGGTCCCCAATCTAC
TCTCACTTCAGCGAGACCGTATCAGGTTTGCCAGTTATCCGTGCCTTTGAGCACCAGCAG
CGATTTCTGAAACACAATGAGGTGAGGATTGACACCAACCAGAAATGTGTCTTTTCCTGG
ATCACCTCCAACAGGTGGCTTGCAATTCGCCTGGAGCTGGTTGGGAACCTGACTGTCTTC
TTTTCAGCCTTGATGATGGTTATTTATAGAGATACCCTAAGTGGGGACACTGTTGGCTTT
GTTCTGTCCAATGCACTCAATATCACACAAACCCTGAACTGGCTGGTGAGGATGACATCA
GAAATAGAGACCAACATTGTGGCTGTTGAGCGAATAACTGAGTACACAAAAGTGGAAAAT
GAGGCACCCTGGGTGACTGATAAGAGGCCTCCGCCAGATTGGCCCAGCAAAGGCAAGATC
CAGTTTAACAACTACCAAGTGCGGTACCGACCTGAGCTGGATCTGGTCCTCAGAGGGATC
ACTTGTGACATCGGTAGCATGGAGAAGATTGGTGTGGTGGGCAGGACAGGAGCTGGAAAG
TCATCCCTCACAAACTGCCTCTTCAGAATCTTAGAGGCTGCCGGTGGTCAGATTATCATT
GATGGAGTAGATATTGCTTCCATTGGGCTCCACGACCTCCGAGAGAAGCTGACCATCATC
CCCCAGGACCCCATCCTGTTCTCTGGAAGCCTGAGGATGAATCTCGACCCTTTCAACAAC
TACTCAGATGAGGAGATTTGGAAGGCCTTGGAGCTGGCTCACCTCAAGTCTTTTGTGGCC
AGCCTGCAACTTGGGTTATCCCACGAAGTGACAGAGGCTGGTGGCAACCTGAGCATAGGC
CAGAGGCAGCTGCTGTGCCTGGGCAGGGCTCTGCTTCGGAAATCCAAGATCCTGGTCCTG
GATGAGGCCACTGCTGCGGTGGATCTAGAGACAGACAACCTCATTCAGACGACCATCCAA
AACGAGTTCGCCCACTGCACAGTGATCACCATCGCCCACAGGCTGCACACCATCATGGAC
AGTGACAAGGTAATGGTCCTAGACAACGGGAAGATTATAGAGTGCGGCAGCCCTGAAGAA
CTGCTACAAATCCCTGGACCCTTTTACTTTATGGCTAAGGAAGCTGGCATTGAGAATGTG
AACAGCACAAAATTCTAG

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
U63970

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_13_Locus:
10q24

# Macromolecular_Interacting_Partner_13_SNPs:
rs2273697; rs927344; rs7080681; rs8187699; rs8187692; rs17216317; rs17222723; rs8187710; rs17222674; rs17222547; rs8187706; rs3740070; rs8187709; rs8187707; rs3740066; rs17216198; rs7899457; rs17216296; rs1137968; rs4267009; rs34937870; rs717620; rs17216156; rs2002042; rs2804400; rs2756109; rs2073337; rs2756114; rs8187674; rs3740065; rs2756104; rs4148396; rs4148397; rs7393105; rs3740063; rs6584327; rs3740073; rs4148398; rs2756106; rs2756112; rs7476245; rs3740064; rs3740074; rs17112266; rs4581377; rs2756103; rs9794323; rs11818057; rs3758395; rs7914602; rs4148399; rs2073336; rs2756113; rs4148391; rs11597282; rs10786571; rs4148384; rs4077146; rs4148394; rs2756105; rs2804398; rs2224506; rs3740067; rs11595888; rs35885490; rs2756108; rs7901377; rs10883416; rs4919395; rs3780882; rs7920591; rs9794324; rs2902299; rs34839727; rs10082440; rs3780880; rs4611137; rs3740069; rs35408364; rs7393085; rs7900740; rs12257125; rs10748792; rs7090621; rs34456559; rs7922379; rs9633711; rs4148395; rs34660705; rs11190291; rs11816875; rs10883417; rs2756111; rs2804399; rs34683029; rs7898096; rs7906080; rs35509621; rs3740068; rs9943464; rs12257158; rs10883413; rs11498758; rs10786572; rs2804397; rs7922376; rs10748791; rs1962102; rs9804274; rs4362077; rs2756110; rs10883414; rs9794322; rs9633710; rs7076773; rs7920448; rs1885301; rs7910642; rs2804402; rs12251995; rs3740071; rs3740072; rs41318029; rs4148400; rs41286890; rs4148401; rs11362742; rs35648207; rs12268545; rs35371064; rs11498759; rs12771624; rs28697226; rs11190289; rs10450371; rs35688626; rs2862689; rs35000277; rs35762771; rs33925378; rs35125216; rs4994144; rs3824610; rs10667377; rs12252945; rs35530113; rs34849284; rs35428269; rs34871071; rs4148392; rs34542394; rs10579032; rs34992254; rs3893194; rs9731882; rs10561194; rs35963473; rs33998610; rs34709093; rs2281637; rs35827068; rs11190286; rs9733831; rs3047481; rs34662003; rs35138969; rs34959207; rs9733799; rs9420768; rs4148393; rs10577917; rs9731254; rs35683214; rs11817399; rs4412694; rs34351781; rs36233263; rs41318033; rs1136912; rs12253584; rs35296652; rs10883415; rs34967745; rs7900969; rs11598792; rs7078268; rs41286888; rs3893193; rs11498760; rs35883614; rs4439452; rs41318031; rs28434545; rs4427497; rs35152927; rs7922864; rs33947178; rs10644836; rs28498571; rs10453988; rs34093243; rs33948136; rs34256643; rs11190288; rs9731258; rs3047477; rs11190290; rs11190294; rs11594329; rs36042666; rs35852420; rs3961715; rs4148383; rs34382900; rs35836893; rs3780881; rs28409805; rs35388339; rs10683821; rs7394179; rs34343354; rs34401027; rs9731264; rs35091989; rs12240781; rs3047479; rs10082536; rs5787360; rs35682621; rs5787361; rs4148402; rs34743267; rs12258415; rs34937591; rs28537453; rs34918146; rs5013873; rs28532665; rs11190287; rs12359960; rs7901067; rs10555122; rs11442349; rs35567746; rs41318025; rs36012424; rs35853830; rs10559742; rs4919397; rs34706355; rs7899330; rs12253129; rs41318027; rs34398741; rs35444155; rs41318023; rs11592017; rs2490765; rs34423076; rs34009725; rs34827047; rs34834811; rs35066717; rs3047475; rs34693955; rs34200720; rs35059917; rs11190295; rs11190297; rs11190298; rs1137675; rs11816708; rs12268782; rs12762549; rs12826; rs17216149; rs17216177; rs17216212; rs17216345; rs17222540; rs17222554; rs17222561; rs17222589; rs17222596; rs17222610; rs17222624; rs17222632; rs17222744; rs17580483; rs2145852; rs2145853; rs2180989; rs2180990; rs2249983; rs2756098; rs2756107; rs4148385; rs4148386; rs4148387; rs4148388; rs4148389; rs7067971; rs7068581; rs7476419; rs7898268; rs7899883; rs7903716

# Macromolecular_Interacting_Partner_13_General_References:
8797578; 8662992; 10464142; 11076395; 11500505; 9425227; 10053008; 11093739; 11477083; 11266082

# Macromolecular_Interacting_Partner_13_References:
12763363

# Macromolecular_Interacting_Partner_14_ID:
5692

# Macromolecular_Interacting_Partner_14_Name:
Solute carrier organic anion transporter family member 1B1

# Macromolecular_Interacting_Partner_14_Synonyms:
Solute carrier family 21 member 6; Sodium-independent organic anion- transporting polypeptide 2; OATP 2; Liver-specific organic anion transporter 1; LST-1; OATP-C

# Macromolecular_Interacting_Partner_14_Gene_Name:
SLCO1B1

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>Solute carrier organic anion transporter family member 1B1
MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFE
ISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGY
YRYSKETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNML
RGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYV
DLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLHVLE
TNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVF
KYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLS
FYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGIT
YISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAI
QVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCI
KWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASE
NGSVMDEANLESLNKNKHFVPSAGADSETHC

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
691

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
76450

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
8.68

# Macromolecular_Interacting_Partner_14_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_14_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_14_Specific_Function:
Mediates the Na(+)-independent transport of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver

# Macromolecular_Interacting_Partner_14_Pathway:
Not Available

# Macromolecular_Interacting_Partner_14_Reaction:
Not Available

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF07648:Kazal_2;
PF03137:OATP

# Macromolecular_Interacting_Partner_14_Signals:
None

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
97-117
207-227
259-279
336-356
376-396
410-430
575-595

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
5051630

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
SO1B1_HUMAN (Q9Y6L6)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
SLCO1B1

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
SLCO1B1

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:10959

# Macromolecular_Interacting_Partner_14_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Cell membrane; basolateral cell membrane; multi-pass membrane protein. Note=Detected in basolateral membranes of hepatocytes

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>2076 bp
ATGGACCAAAATCAACATTTGAATAAAACAGCAGAGGCACAACCTTCAGAGAATAAGAAA
ACAAGATACTGCAATGGATTGAAGATGTTCTTGGCAGCTCTGTCACTCAGCTTTATTGCT
AAGACACTAGGTGCAATTATTATGAAAAGTTCCATCATTCATATAGAACGGAGATTTGAG
ATATCCTCTTCTCTTGTTGGTTTTATTGACGGAAGCTTTGAAATTGGAAATTTGCTTGTG
ATTGTATTTGTGAGTTACTTTGGATCCAAACTACATAGACCAAAGTTAATTGGAATCGGT
TGTTTCATTATGGGAATTGGAGGTGTTTTGACTGCTTTGCCACATTTCTTCATGGGATAT
TACAGGTATTCTAAAGAAACTAATATCAATTCATCAGAAAATTCAACATCGACCTTATCC
ACTTGTTTAATTAATCAAATTTTATCACTCAATAAAGCATCACCTGAGATAGTGGGAAAA
GGTTGTTTAAAGGAATCTGGGTCATACATGTGGATATATGTGTTCATGGGTAATATGCTT
CGTGGAATAGGGGAGACTCCCATAGTACCACTGGGGCTTTCTTACATTGATGATTTCGCT
AAAGAAGGACATTCTTCTTTGTATTTAGGTATATTGAATGCAATAGCAATGATTGGTCCA
ATCATTGGCTTTACCCTGGGATCTCTGTTTTCTAAAATGTACGTGGATATTGGATATGTT
AATCTAAGCACTATCAGGATAACTCCTACTGATTCTCGATGGGTTGGAGCTTGGTGGCTT
AATTTCCTTGTGTCTGGACTATTCTCCATTATTTCTTCCATACCATTCTTTTTCTTGCCC
CAAACTCCAAATAAACCACAAAAAGAAAGAAAAGCTTCACTGTCTTTGCATGTGCTGGAA
ACAAATGATGAAAAGGATCAAACAGCTAATTTGACCAATCAAGGAAAAAATATTACCAAA
AATGTGACTGGTTTTTTCCAGTCTTTTAAAAGCATCCTTACTAATCCCCTGTATGTTATG
TTTGTGCTTTTGACGTTGTTACAAGTAAGCAGCTATATTGGTGCTTTTACTTATGTCTTC
AAATACGTAGAGCAACAGTATGGTCAGCCTTCATCTAAGGCTAACATCTTATTGGGAGTC
ATAACCATACCTATTTTTGCAAGTGGAATGTTTTTAGGAGGATATATCATTAAAAAATTC
AAACTGAACACCGTTGGAATTGCCAAATTCTCATGTTTTACTGCTGTGATGTCATTGTCC
TTTTACCTATTATATTTTTTCATACTCTGTGAAAACAAATCAGTTGCCGGACTAACCATG
ACCTATGATGGAAATAATCCAGTGACATCTCATAGAGATGTACCACTTTCTTATTGCAAC
TCAGACTGCAATTGTGATGAAAGTCAATGGGAACCAGTCTGTGGAAACAATGGAATAACT
TACATCTCACCCTGTCTAGCAGGTTGCAAATCTTCAAGTGGCAATAAAAAGCCTATAGTG
TTTTACAACTGCAGTTGTTTGGAAGTAACTGGTCTCCAGAACAGAAATTACTCAGCCCAT
TTGGGTGAATGCCCAAGAGATGATGCTTGTACAAGGAAATTTTACTTTTTTGTTGCAATA
CAAGTCTTGAATTTATTTTTCTCTGCACTTGGAGGCACCTCACATGTCATGCTGATTGTT
AAAATTGTTCAACCTGAATTGAAATCACTTGCACTGGGTTTCCACTCAATGGTTATACGA
GCACTAGGAGGAATTCTAGCTCCTATATATTTTGGGGCTCTGATTGATACAACGTGTATA
AAGTGGTCCACCAACAACTGTGGCACACGTGGGTCATGTAGGACATATAATTCCACATCA
TTTTCAAGGGTCTACTTGGGCTTGTCTTCAATGTTAAGAGTCTCATCACTTGTTTTATAT
ATTATATTAATTTATGCCATGAAGAAAAAATATCAAGAGAAAGATATCAATGCATCAGAA
AATGGAAGTGTCATGGATGAAGCAAACTTAGAATCCTTAAATAAAAATAAACATTTTGTC
CCTTCTGCTGGGGCAGATAGTGAAACACATTGTTAA

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
AF060500

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_14_Locus:
12p

# Macromolecular_Interacting_Partner_14_SNPs:
rs2306283; rs4149056; rs2306282; rs11045819; rs11045852; rs34671512; rs2291075; rs4149057; rs11045818; rs11045854; rs11045859; rs3829310; rs3829307; rs3829306; rs1292914; rs2010668; rs4149085; rs7296230; rs11045891; rs12370655; rs11045782; rs4149087; rs7484637; rs12816706; rs1101248; rs4149088; rs11045783; rs4149019; rs1101250; rs4149018; rs10841752; rs3829309; rs11045784; rs2417954; rs2169970; rs999278; rs2417955; rs2061903; rs1000691; rs2291076; rs1564364; rs12812279; rs2900478; rs7973095; rs7137959; rs12320965; rs717958; rs6487213; rs4149026; rs3899743; rs717959; rs4149033; rs1564365; rs11045799; rs10743408; rs2199763; rs976754; rs4149061; rs2291077; rs4149042; rs4149069; rs2417957; rs4149022; rs4762698; rs11045823; rs4149062; rs2291073; rs11045786; rs987839; rs4149063; rs7295464; rs7299630; rs7139376; rs7969061; rs11045878; rs11045808; rs4149035; rs7969341; rs7966613; rs2417968; rs4149044; rs7137060; rs11045796; rs2219828; rs11045815; rs10841753; rs7965941; rs1120964; rs12372124; rs11045821; rs16923519; rs10841754; rs1871395; rs12427008; rs4149034; rs11045864; rs7966129; rs17329885; rs981264; rs4149045; rs11045785; rs4149050; rs4363657; rs11830252; rs4149064; rs2100996; rs7966037; rs4149058; rs7966269; rs981262; rs10841767; rs11045816; rs7296796; rs11045829; rs11045813; rs4149041; rs7978219; rs4149051; rs4149053; rs12305884; rs7962588; rs4149029; rs4149078; rs11045848; rs2417966; rs964614; rs7138177; rs11045825; rs7313506; rs11045863; rs7489119; rs4149032; rs7977197; rs10841763; rs10444413; rs4149040; rs7136150; rs4149036; rs4149054; rs1564370; rs7136445; rs12578392; rs12582717; rs964615; rs12310216; rs2417967; rs4149081; rs7966581; rs4149073; rs2169968; rs11045797; rs7966448; rs4149048; rs4149037; rs11045824; rs1987385; rs7486079; rs7969160; rs11045820; rs11045834; rs7310315; rs11045889; rs12319308; rs4149030; rs991263; rs11045890; rs11045836; rs11045844; rs11045877; rs10841766; rs4149067; rs4762697; rs11045869; rs12829704; rs2086271; rs4149023; rs12297423; rs11045812; rs11045802; rs11045885; rs11045805; rs12366582; rs7977097; rs7358672; rs4149076; rs2417963; rs12580258; rs4149066; rs4312110; rs7959887; rs991262; rs10841762; rs7962226; rs11045870; rs7971917; rs2046032; rs9669752; rs12830367; rs12296695; rs11833223; rs7962004; rs7957064; rs12302130; rs12315464; rs10841755; rs4149072; rs2417956; rs11045868; rs12307624; rs4149025; rs11045876; rs4381410; rs12317268; rs11045881; rs12821068; rs12812795; rs11045790; rs2291074; rs4149068; rs12303713; rs12313639; rs7956893; rs10743410; rs9668441; rs1987386; rs7961665; rs2417961; rs11045879; rs7306982; rs4149084; rs11045800; rs12318652; rs4149046; rs7307371; rs12307943; rs7956506; rs11045789; rs12369881; rs12305163; rs17388851; rs11045822; rs7957274; rs11045857; rs4149075; rs11045814; rs11615107; rs10841756; rs10841758; rs9669758; rs11045884; rs12312746; rs4149074; rs11045862; rs3919879; rs7954542; rs4149028; rs11045809; rs4149071; rs3830216; rs1564369; rs10841764; rs4149047; rs4149049; rs12311454; rs1871396; rs12372300; rs12305852; rs7962129; rs7958771; rs4149021; rs4149038; rs4149052; rs1988807; rs2127301; rs12368356; rs4149070; rs7137806; rs7968318; rs12310977; rs11045887; rs10841760; rs11045803; rs11045845; rs2127303; rs7956885; rs12315627; rs7953338; rs11045831; rs4149031; rs10770791; rs10770789; rs12371604; rs7980544; rs7957297; rs12302293; rs11834710; rs7294549; rs11045858; rs2169969; rs7297468; rs9669760; rs996124; rs12319213; rs12368894; rs12821228; rs10841757; rs10841759; rs11045801; rs1463565; rs10841765; rs1002552; rs11045828; rs7958671; rs4149027; rs4149024; rs12426084; rs11045787; rs12301796; rs7968317; rs12424765; rs10841768; rs7485550; rs11513225; rs2199765; rs10770792; rs2199766; rs6487214; rs7973837; rs7956886; rs10841761; rs4149082; rs1564366; rs10770790; rs11513411; rs11835045; rs12372157; rs4149014; rs17328763; rs11045893; rs11045892; rs4149013; rs11557087; rs4603354; rs11045853; rs3829308; rs4149086; rs34805753; rs35029154; rs4149017; rs34568199; rs34951575; rs12810986; rs4149089; rs35685797; rs4149091; rs34209816; rs34564768; rs1101249; rs12810599; rs4149092; rs4149016; rs1101251; rs1564362; rs34412011; rs9739284; rs12812227; rs12371160; rs35694378; rs28373147; rs11045781; rs35580583; rs12811096; rs12318078; rs1564361; rs1564363; rs4542460; rs11045780; rs36147810; rs4149090; rs12582669; rs34770540; rs2169967; rs35201007; rs35733645; rs11045882; rs11385923; rs11045791; rs5796893; rs11045849; rs35416146; rs7954207; rs10718437; rs11045855; rs35374921; rs12830545; rs12423134; rs35163063; rs34196286; rs34071906; rs35247215; rs12318075; rs7296435; rs28673691; rs10632490; rs4573740; rs34314656; rs33935989; rs28853611; rs35380692; rs7306239; rs35412568; rs1564367; rs35334634; rs11519273; rs34706516; rs10610238; rs12371570; rs11535997; rs7969577; rs4149083; rs35236625; rs35285913; rs2199764; rs11045874; rs11045830; rs11045851; rs12423121; rs35904483; rs4149098; rs34700678; rs11513413; rs11045860; rs3060544; rs12308079; rs34656931; rs3060614; rs12297133; rs35642680; rs11454454; rs34138322; rs11045826; rs12821033; rs35034604; rs35375240; rs12369359; rs11045841; rs5796892; rs34888642; rs4149060; rs11045856; rs7962611; rs11045888; rs35548137; rs35051063; rs4149079; rs2900479; rs34632551; rs12819994; rs35933705; rs35573378; rs3886198; rs12314902; rs12304130; rs11045832; rs34111581; rs12305699; rs7301251; rs35406304; rs12579183; rs12303414; rs35462387; rs11519274; rs34413949; rs9669765; rs34276829; rs11407708; rs2417964; rs34527818; rs35157563; rs1564368; rs12303159; rs11045840; rs11533476; rs11045806; rs11282766; rs11045873; rs7966270; rs11522782; rs7978260; rs12146883; rs34679454; rs12306105; rs4322445; rs34728625; rs34943592; rs12371691; rs35736025; rs6487212; rs4620775; rs35722973; rs5796891; rs34804201; rs28588986; rs35928112; rs12367262; rs12316905; rs17330253; rs12367888; rs7955751; rs11045842; rs4149099; rs11045807; rs34447226; rs7971855; rs35639129; rs12319834; rs4149065; rs2900477; rs34483590; rs7971104; rs11513414; rs28782899; rs12423136; rs11045827; rs12580064; rs34867520; rs3962562; rs12423123; rs4149077; rs12366994; rs11045872; rs12826050; rs7953829; rs3060502; rs34366034; rs10697756; rs7978634; rs12313667; rs11045838; rs11045875; rs34882548; rs35706009; rs11045798; rs12306098; rs2417965; rs35399651; rs7315147; rs12367371; rs35901911; rs4149096; rs12313491; rs11045883; rs4149100; rs12317451; rs6487211; rs11045886; rs34474710; rs12812334; rs4149080; rs35448052; rs12303784; rs35133125; rs4149043; rs7975393; rs12423150; rs36005374; rs11045833; rs11045788; rs4149055; rs11045866; rs11045793; rs35366829; rs2900476; rs12814646; rs35767860; rs11045861; rs7971088; rs35056525; rs35577038; rs2417962; rs10466794; rs35786525; rs11045847; rs3060579; rs34234515; rs34241429; rs11385920; rs11045850; rs11045837; rs4149059; rs12815795; rs11045871; rs11045839; rs11045792; rs28854565; rs35653374; rs7966140; rs11045811; rs11519275; rs12316911; rs9634094; rs34793374; rs35515882; rs34702734; rs34244521; rs12313499; rs7132052; rs11357260; rs35641021; rs11045846; rs12833325; rs11045843; rs11519272; rs35924420; rs35152201; rs11610616; rs34577475; rs4149015; rs10841751; rs10841769; rs11045776; rs11045777; rs11045778; rs11045895; rs11045900; rs11045901; rs12368786; rs12370842; rs12372067; rs12372111; rs12372162; rs17387842; rs327543; rs327544; rs327545; rs4149012; rs704166; rs7302619; rs7302951; rs7303299; rs7960384; rs7960688; rs7966893; rs852549; rs852550

# Macromolecular_Interacting_Partner_14_General_References:
10358072; 10601278; 10644574; 10779507; 11477075; 12196548; 12130747

# Macromolecular_Interacting_Partner_14_References:
14530907; 16479312

# Macromolecular_Interacting_Partner_15_ID:
7885

# Macromolecular_Interacting_Partner_15_Name:
Gamma-glutamyltranspeptidase 1 precursor

# Macromolecular_Interacting_Partner_15_Synonyms:
Gamma- glutamyltransferase 1; GGT 1; CD224 antigen[Contains: Gamma- glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain]

# Macromolecular_Interacting_Partner_15_Gene_Name:
GGT1

# Macromolecular_Interacting_Partner_15_Protein_Sequence:
>Gammaglutamyltranspeptidase 1 precursor
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRD
GGSAVDAAIA
ALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMF
NSSEQSQKGGLSVAVPGEIRG
YELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAAL
ENKRTVIEQQPVLCEVFCRDRKVLREGERLTL
PQLADTYETLAIEGAQAFYNGSLTAQI
VKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAP
LSGPVLALILNILKGY
NFSRESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFF
AAQLR
AQISDDTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGI
LFNNE
MDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGG
TQITTATALAIIYNLW
FGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHH
TQIASTFIAVVQAIVRTAGGWAAASDS
RKGGEPAGY

# Macromolecular_Interacting_Partner_15_Number_of_Residues:
569

# Macromolecular_Interacting_Partner_15_Molecular_Weight:
61411

# Macromolecular_Interacting_Partner_15_Theoretical_pI:
7.14

# Macromolecular_Interacting_Partner_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring amino-acyl groups
Function:  gamma-glutamyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_15_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_15_Specific_Function:
Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive

# Macromolecular_Interacting_Partner_15_Pathway:
map00430  Taurine and hypotaurine metabolism;
 map00450  Selenoamino acid metabolism;
 map00460  Cyanoamino acid metabolism;
 map00480  Glutathione metabolism;
 map00590  Prostaglandin and leukotriene metabolism

# Macromolecular_Interacting_Partner_15_Reaction:
(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid

# Macromolecular_Interacting_Partner_15_Pfam_Domain_Function:
PF01019:G_glu_transpept

# Macromolecular_Interacting_Partner_15_Signals:
1-30

# Macromolecular_Interacting_Partner_15_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_15_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_15_EC_Link:
EC 2.3.2.2

# Macromolecular_Interacting_Partner_15_GenBank_ID_Protein:
183138

# Macromolecular_Interacting_Partner_15_SwissProt_ID:
GGT1_HUMAN (P19440)

# Macromolecular_Interacting_Partner_15_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_15_Genecard_id:
GGT1

# Macromolecular_Interacting_Partner_15_Geneatlas_id:
GGT1

# Macromolecular_Interacting_Partner_15_hgnc_id:
HGNC:4250

# Macromolecular_Interacting_Partner_15_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_15_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_15_Gene_Sequence:
>1710 bp

ATGAAGAAGAAGTTAGTGGTGCTGGGCCTGCTGGCCGTGGTCCTGGTGCTGGTCATTGT
CGGCCTCTGTC
TCTGGCTGCCCTCAGCCTCCAAGGAACCTGACAACCATGTGTACACCA
GGGCTGCCGTGGCCGCGGATGC
CAAGCAGTGCTCGAAGATTGGGAGGGATGCACTGCGG
GACGGTGGCTCTGCGGTGGATGCAGCCATTGCA
GCCCTGTTGTGTGTGGGGCTCATGAA
TGCCCACAGCATGGGCATCGGGGGTGGCCTCTTCCTCACCATCT
ACAACAGCACCACAC
GAAAAGCTGAGGTCATCAACGCCCGCGAGGTGGCCCCCAGGCTGGCCTTTGCCAC
CATG
TTCAACAGCTCGGAGCAGTCCCAGAAGGGGGGGCTGTCGGTGGCGGTGCCTGGGGAGATC
CGAGGC
TATGAGCTGGCACACCAGCGGCATGGGCGGCTGCCCTGGGCTCGCCTCTTCCA
GCCCAGCATCCAGCTGG
CCCGCCAGGGCTTCCCCGTGGGCAAGGGCTTGGCGGCAGCCC
TGGAAAACAAGCGGACCGTCATCGAGCA
GCAGCCTGTCTTGTGTGAGGTGTTCTGCCGG
GATAGAAAGGTGCTTCGGGAGGGGGAGAGACTGACCCTG
CCGCAGCTGGCTGACACCTA
CGAGACGCTGGCCATCGAGGGTGCCCAGGCCTTCTACAACGGCAGCCTCA
CGGCCCAGA
TTGTGAAGGACATCCAGGCGGCCGGGGGCATTGTGACAGCTGAGGACCTGAACAACTACC
G
TGCTGAGCTGATCGAGCACCCGCTGAACATCAGCCTGGGAGACGCGGTGCTGTACATG
CCCAGTGCGCCG
CTCAGCGGGCCCGTGCTGGCCCTCATCCTCAACATCCTCAAAGGGTA
CAACTTCTCCCGGGAGAGCGTGG
AGAGCCCCGAGCAGAAGGGCCTGACGTACCACCGCA
TCGTAGAGGCTTTCCGGTTTGCCTACGCCAAGAG
GACCCTGCTTGGGGACCCCAAGTTT
GTGGATGTGACTGAGGTGGTCCGCAACATGACCTCCGAGTTCTTC
GCTGCCCAGCTCCG
GGCCCAGATCTCTGACGACACCACTCACCCGATCTCCTACTACAAGCCCGAGTTCT
ACA
CGCCGGATGACGGGGGCACTGCTCACCTGTCTGTCGTCGCAGAGGACGGCAGTGCTGTGT
CCGCCAC
CAGCACCATCAACCTCTACTTTGGCTCCAAGGTCCGCTCCCCGGTCAGCGGG
ATCCTGTTCAATAATGAA
ATGGACGACTTCAGCTCTCCCAGCATCACCAACGAGTTTGG
GGTACCCCCCTCACCTGCCAATTTCATCC
AGCCAGGGAAGCAGCCGCTCTCGTCCATGT
GCCCGACGATCATGGTGGGCCAGGACGGCCAGGTCCGGAT
GGTGGTGGGAGCTGCTGGG
GGCACACAGATCACCACGGCCACTGCACTGGCCATCATCTACAACCTCTGG
TTCGGCTA
TGACGTGAAGCGGGCCGTGGAGGAGCCCCGGCTGCACAACCAGCTTCTGCCCAACGTCAC
GA
CAGTGGAGAGAAACATTGACCAGGCAGTGACTGCAGCCCTGGAGACCCGGCACCATC
ACACCCAGATCGC
GTCCACCTTCATCGCTGTGGTGCAAGCCATCGTCCGCACGGCTGGT
GGCTGGGCAGCTGCCTCGGACTCC
AGGAAAGGCGGGGAGCCTGCCGGCTACTGA

# Macromolecular_Interacting_Partner_15_GenBank_ID_Gene:
J04131

# Macromolecular_Interacting_Partner_15_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_15_Locus:
22q11.23

# Macromolecular_Interacting_Partner_15_SNPs:
rs2330837; rs3895576; rs2330838; rs2017869; rs2330795; rs2073398; rs9624507; rs2006092; rs6519520; rs5751901; rs6519519; rs7284489; rs3788375; rs7292010; rs5760495; rs4049889; rs2006094; rs5760494; rs2001180; rs6004192; rs5751905; rs5760493; rs2006227; rs9624506; rs2005589; rs4822516; rs5751904; rs2073397; rs5760492; rs2076999; rs3859862; rs2010657; rs2003757; rs16990490; rs8138050; rs4049918; rs9608300; rs2017188; rs1807629; rs2330797; rs4822517; rs6004195; rs7286626; rs3747117; rs5760491; rs2330805; rs9624510; rs743371; rs3876104; rs4820600; rs5751902; rs5760490; rs6004193; rs6004194; rs8135987; rs8139070; rs5751909; rs5751910; rs9306396; rs9612676; rs5760505; rs2330848; rs5760499; rs5760497; rs5760504; rs4049843; rs9680722; rs2330841; rs524033; rs11913233; rs9680724; rs4049855; rs380131; rs3934421; rs4822523; rs5760500; rs6004203; rs3901297; rs5760498; rs391837; rs5751908; rs9680612; rs3895577; rs4822520; rs4049869; rs3895575; rs7511507; rs7511598; rs389004; rs2236626; rs7285339; rs2330842; rs4049882; rs4049829; rs28621555; rs2330836; rs3966247; rs12159765; rs4049897; rs4049881; rs9612682; rs2330843; rs4049844; rs4049883; rs2330844; rs5751900; rs2330830; rs12169166; rs4049900; rs2330818; rs2330826; rs9624503; rs3966256; rs9612663; rs3966255; rs3895580; rs4049911; rs2877222; rs2330801; rs3033885; rs9624509; rs6004196; rs4049914; rs2330835; rs1832359; rs28509371; rs4049896; rs2298391; rs2330825; rs9624505; rs2877224; rs4049885; rs2330811; rs4049917; rs2330806; rs3876101; rs3887791; rs12484586; rs4049890; rs8139074; rs3895578; rs28550867; rs4049905; rs4049925; rs3966259; rs673673; rs753462; rs4049899; rs2330813; rs8138031; rs4049895; rs28605797; rs3966263; rs3876105; rs9612666; rs2330808; rs2330832; rs2076800; rs13057657; rs3033738; rs3966257; rs2330803; rs2330815; rs4049912; rs3033744; rs2330810; rs2330800; rs3895574; rs6004191; rs8137090; rs2330807; rs2330834; rs4049913; rs28449741; rs2330827; rs3966260; rs9624504; rs2330817; rs9612671; rs4049903; rs2877221; rs5751903; rs2330824; rs2079567; rs2330796; rs4049898; rs11913684; rs2877225; rs2330831; rs4049891; rs4049915; rs2330812; rs4049910; rs4049916; rs4049908; rs12106564; rs3876100; rs3859863; rs3032936; rs9624508; rs4049901; rs12163146; rs4049924; rs4049906; rs2330819; rs9612664; rs3788376; rs3895579; rs2330822; rs2330804; rs2330823; rs2077120; rs2089350; rs2330814; rs2006093; rs4049904; rs9608301; rs3865759; rs2330799; rs3966258; rs28566494; rs2330820; rs3876103; rs2330802; rs4049926; rs3894886; rs3966262; rs2079568; rs2330816; rs2330809; rs2330798; rs2877223; rs4049902; rs8139073; rs4049865; rs4049850; rs4049857; rs2877228; rs28663139; rs4049837; rs4049873; rs4049867; rs4049860; rs28545702; rs34659550; rs3865654; rs4049863; rs28377326; rs3865651; rs4535160; rs4049839; rs11913428; rs2096530; rs28366457; rs4049828; rs3865649; rs9608303; rs4049861; rs6004202; rs2330853; rs6004200; rs4049833; rs10602389; rs9624512; rs4049875; rs2330849; rs3865659; rs3966245; rs2330852; rs12167273; rs4049847; rs2096529; rs4049868; rs7287997; rs4049880; rs4049835; rs3865653; rs11703306; rs4049878; rs2330846; rs3865657; rs35411004; rs2330850; rs5760509; rs12168759; rs9620404; rs4049870; rs9612673; rs5760510; rs4049836; rs28441370; rs12170528; rs4049849; rs4049827; rs4049851; rs3865655; rs4049872; rs3865650; rs6004205; rs5751911; rs4049858; rs4049879; rs2877229; rs2330845; rs6004201; rs12159496; rs4426615; rs4049838; rs2877230; rs12168762; rs28418841; rs4049877; rs3876106; rs28477676; rs5760503; rs3938847; rs9620400; rs2330847; rs4049842; rs28402861; rs28718168; rs3865658; rs4049856; rs2877227; rs12166510; rs4049832; rs7284160; rs2105500; rs11416248; rs493075; rs2877231; rs3966265; rs2330851; rs3966264; rs6004198; rs3897519; rs4049864; rs4049854; rs4049830; rs3865656; rs2845424; rs9612672; rs5751465; rs4049871; rs11912608; rs9620401; rs2330840; rs4049859; rs28451181; rs4049834; rs4049862; rs9612679; rs3034881; rs4049874; rs3865652; rs35525727; rs3035043; rs12158857; rs2330854; rs35882418; rs5760483; rs11318518; rs11913638; rs12158094; rs16978739; rs2070477; rs2154611; rs4820599; rs5760485; rs5760488; rs7287904; rs737128; rs743369; rs743370; rs762286; rs874852; rs928785; rs9608299; rs9830

# Macromolecular_Interacting_Partner_15_General_References:
2904146; 2907498; 2563599; 2568315; 1968061; 1378736; 7689219; 10591208; 2896486; 10392451; 19463; 2900635; 8095045; 7759490; 7673200; 8827453

# Macromolecular_Interacting_Partner_15_References:
7488238; 7560859; 8099310

# Macromolecular_Interacting_Partner_16_ID:
8015

# Macromolecular_Interacting_Partner_16_Name:
Small inducible cytokine A4 precursor

# Macromolecular_Interacting_Partner_16_Synonyms:
CCL4; Macrophage inflammatory protein 1-beta; MIP-1-beta; MIP-1-beta(1-69; T-cell activation protein 2; ACT-2; PAT 744; H400; SIS-gamma; Lymphocyte activation gene 1 protein; LAG-1; HC21; G-26 T-lymphocyte-secreted protein[Contains: MIP-1-beta(3-69]

# Macromolecular_Interacting_Partner_16_Gene_Name:
CCL4

# Macromolecular_Interacting_Partner_16_Protein_Sequence:
>Small inducible cytokine A4 precursor
MKLCVTVLSLLMLVAAFCSPALSAPMGSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQ
PAVVFQTKRSKQVCADPSESWVQEYVYDLELN

# Macromolecular_Interacting_Partner_16_Number_of_Residues:
92

# Macromolecular_Interacting_Partner_16_Molecular_Weight:
10212

# Macromolecular_Interacting_Partner_16_Theoretical_pI:
4.88

# Macromolecular_Interacting_Partner_16_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  chemokine activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_16_General_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Specific_Function:
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B

# Macromolecular_Interacting_Partner_16_Pathway:
Not Available

# Macromolecular_Interacting_Partner_16_Reaction:
Not Available

# Macromolecular_Interacting_Partner_16_Pfam_Domain_Function:
PF00048:IL8

# Macromolecular_Interacting_Partner_16_Signals:
1-23

# Macromolecular_Interacting_Partner_16_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_16_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_16_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_16_GenBank_ID_Protein:
178018

# Macromolecular_Interacting_Partner_16_SwissProt_ID:
CCL4_HUMAN (P13236)

# Macromolecular_Interacting_Partner_16_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_16_Genecard_id:
CCL4

# Macromolecular_Interacting_Partner_16_Geneatlas_id:
CCL4

# Macromolecular_Interacting_Partner_16_hgnc_id:
HGNC:10630

# Macromolecular_Interacting_Partner_16_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_16_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_16_Gene_Sequence:
>279 bp
ATGAAGCTCTGCGTGACTGTCCTGTCTCTCCTCATGCTAGTAGCTGCCTTCTGCTCTCCA
GCGCTCTCAGCACCAATGGGCTCAGACCCTCCCACCGCCTGCTGCTTTTCTTACACCGCG
AGGAAGCTTCCTCGCAACTTTGTGGTAGATTACTATGAGACCAGCAGCCTCTGCTCCCAG
CCAGCTGTGGTATTCCAAACCAAAAGAAGCAAGCAAGTCTGTGCTGATCCCAGTGAATCC
TGGGTCCAGGAGTACGTGTATGACCTGGAACTGAACTGA

# Macromolecular_Interacting_Partner_16_GenBank_ID_Gene:
J04130

# Macromolecular_Interacting_Partner_16_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_16_Locus:
17q12

# Macromolecular_Interacting_Partner_16_SNPs:
rs1130750; rs1719152; rs9635771; rs1049807; rs1049750; rs2905541; rs1049811; rs1049828; rs1049824; rs1049833; rs1634517; rs1719144; rs2663832; rs1719145; rs1719147; rs1719148; rs4606761; rs1634516; rs7224167; rs2663833; rs1719149; rs1719140; rs1719153; rs9896211; rs1049746; rs1719141; rs1634514; rs1719142; rs7405858; rs2905540; rs10491121; rs1634518; rs1634513; rs1130760; rs1049805; rs1130755; rs1719146; rs1049804; rs1049834; rs1049838; rs1049839; rs1049813; rs1049821; rs1049840; rs1049837; rs1049819; rs1049823; rs1049815; rs1049826; rs9891632; rs2905542; rs11298041; rs7218357; rs1634515; rs1719150; rs9895812; rs4991992; rs4991991; rs4013799; rs3216921; rs34562211; rs4993527; rs7501539; rs2011522; rs940001; rs1719139; rs2376462; rs9895259; rs4993526; rs35451259; rs11658357; rs12453700; rs1357365; rs1619526; rs1619600; rs1622080; rs1626203; rs1634504; rs1634505; rs1634507; rs1634508; rs1634509; rs1634510; rs1634522; rs1634523; rs1634524; rs1634525; rs1719205; rs1719210; rs17617372; rs2072091; rs7207117; rs916839; rs9892580; rs9912185

# Macromolecular_Interacting_Partner_16_General_References:
2462251; 2521882; 2521353; 2247088; 2568930; 1894635; 2809212; 9521068; 8525373; 12070155; 12401480; 8134838

# Macromolecular_Interacting_Partner_16_References:
12388182

# Macromolecular_Interacting_Partner_17_ID:
8186

# Macromolecular_Interacting_Partner_17_Name:
Solute carrier organic anion transporter family member 1A2

# Macromolecular_Interacting_Partner_17_Synonyms:
Solute carrier family 21 member 3; Sodium-independent organic anion transporter; Organic anion-transporting polypeptide 1; OATP1; OATP- A

# Macromolecular_Interacting_Partner_17_Gene_Name:
SLCO1A2

# Macromolecular_Interacting_Partner_17_Protein_Sequence:
>Solute carrier organic anion transporter family member 1A2
MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGF
INGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVS
VSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGI
SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTR
WVGAWWFGFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYG
ITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGI
YNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINT
SYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMV
FQNCSCIQTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMK
SEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYI
YLGLPAALRGSSFVPALIILILLRKCHLPGENASSGTELIETKVKGKENECKDIYQKSTV
LKDDELKTKL

# Macromolecular_Interacting_Partner_17_Number_of_Residues:
670

# Macromolecular_Interacting_Partner_17_Molecular_Weight:
74146

# Macromolecular_Interacting_Partner_17_Theoretical_pI:
5.75

# Macromolecular_Interacting_Partner_17_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_17_General_Function:
Not Available

# Macromolecular_Interacting_Partner_17_Specific_Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids

# Macromolecular_Interacting_Partner_17_Pathway:
Not Available

# Macromolecular_Interacting_Partner_17_Reaction:
Not Available

# Macromolecular_Interacting_Partner_17_Pfam_Domain_Function:
PF07648:Kazal_2;
PF03137:OATP

# Macromolecular_Interacting_Partner_17_Signals:
1-36

# Macromolecular_Interacting_Partner_17_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_17_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_17_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_17_GenBank_ID_Protein:
885978

# Macromolecular_Interacting_Partner_17_SwissProt_ID:
SO1A2_HUMAN (P46721)

# Macromolecular_Interacting_Partner_17_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_17_Genecard_id:
SLCO1A2

# Macromolecular_Interacting_Partner_17_Geneatlas_id:
SLCO1A2

# Macromolecular_Interacting_Partner_17_hgnc_id:
HGNC:10956

# Macromolecular_Interacting_Partner_17_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_17_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_17_Gene_Sequence:
>2013 bp
ATGGGAGAAACTGAGAAAAGAATTGAAACCCATAGAATAAGATGTCTTTCCAAGTTGAAG
ATGTTTCTGTTGGCAATAACATGTGCATTTGTATCCAAAACACTGTCTGGATCTTATATG
AATTCCATGCTCACACAAATAGAGAGACAATTCAACATCCCAACATCTCTAGTTGGATTC
ATTAATGGAAGCTTTGAGATTGGAAATCTTTTGTTGATTATATTTGTGAGTTATTTTGGA
ACCAAACTGCATAGACCTATAATGATTGGCATTGGATGTGTGGTTATGGGCTTAGGCTGT
TTCTTAAAATCACTACCTCATTTCCTCATGAACCAATATGAATATGAATCTACAGTTTCA
GTTTCAGGCAACTTGTCCTCAAACAGTTTCTTGTGTATGGAAAATGGAACCCAGATTTTA
AGACCAACGCAGGATCCATCAGAGTGTACAAAGGAAGTTAAATCATTAATGTGGGTGTAC
GTCCTAGTAGGCAATATTGTACGTGGAATGGGTGAAACTCCCATCCTGCCTTTGGGTATT
TCCTATATAGAAGATTTTGCCAAATTTGAAAATTCTCCTTTATATATTGGGCTTGTAGAA
ACAGGAGCTATTATTGGTCCTTTGATTGGACTTTTGTTGGCATCATTCTGTGCAAATGTT
TATGTTGACACTGGATTTGTGAACACAGATGATCTGATCATAACTCCCACTGACACTCGT
TGGGTCGGTGCATGGTGGTTTGGCTTTCTGATTTGTGCAGGAGTTAACGTGCTCACTGCC
ATTCCTTTTTTCTTTTTGCCCAACACACTTCCAAAGGAAGGACTAGAGACTAATGCTGAC
ATCATTAAAAATGAAAATGAAGACAAACAAAAAGAAGAGGTCAAGAAGGAAAAATATGGA
ATCACTAAAGATTTTCTACCTTTCATGAAAAGTCTTTCCTGCAATCCAATTTATATGCTT
TTCATACTTGTAAGTGTGATACAGTTCAATGCATTCGTTAACATGATCTCCTTCATGCCT
AAATACCTAGAACAGCAATATGGAATATCATCTTCAGATGCAATCTTTCTAATGGGTATT
TATAACTTACCTCCAATATGTATTGGATATATAATTGGTGGTTTAATTATGAAGAAGTTC
AAGATTACTGTCAAACAAGCTGCCCACATAGGATGTTGGTTATCCTTACTTGAGTATCTT
CTCTATTTTTTATCTTTTCTCATGACTTGTGAAAATTCTTCAGTTGTTGGAATAAATACC
TCTTATGAAGGAATTCCACAAGATTTATATGTGGAAAATGACATCTTTGCTGATTGCAAT
GTGGATTGCAACTGTCCATCTAAAATATGGGATCCTGTGTGTGGAAACAATGGCTTGTCA
TATCTGTCAGCTTGTCTTGCTGGTTGTGAGACATCCATTGGAACGGGAATAAACATGGTG
TTCCAAAATTGCAGCTGTATTCAAACATCAGGAAATTCATCTGCAGTTCTTGGGCTGTGC
GACAAAGGACCTGACTGTTCCTTGATGCTCCAGTACTTCCTAATCTTGTCAGCGATGAGC
AGTTTCATTTATTCTTTGGCTGCCATACCTGGATATATGGTTCTCTTGAGGTGTATGAAA
TCTGAAGAGAAGTCCCTTGGTGTGGGATTACATACATTTTGCACAAGAGTATTTGCTGGC
ATTCCTGCACCTATATATTTTGGCGCTTTAATGGATTCCACATGTTTACACTGGGGAACT
TTGAAATGTGGTGAGTCAGGGGCATGCAGGATATATGATTCCACCACCTTCAGATACATC
TACCTCGGATTGCCGGCAGCACTAAGAGGATCAAGCTTTGTTCCAGCCTTAATCATCTTA
ATTCTTTTGAGGAAGTGTCATCTACCTGGTGAAAATGCCTCTTCAGGAACAGAGCTTATA
GAGACAAAAGTCAAAGGGAAGGAAAATGAGTGCAAAGATATATACCAAAAGTCCACGGTT
TTGAAAGATGATGAATTGAAAACTAAATTGTAA

# Macromolecular_Interacting_Partner_17_GenBank_ID_Gene:
U21943

# Macromolecular_Interacting_Partner_17_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_17_Locus:
12p12

# Macromolecular_Interacting_Partner_17_SNPs:
rs11568567; rs2199688; rs11568563; rs3764045; rs10841795; rs11568574; rs11568554; rs11568550; rs2045938; rs4148978; rs10459076; rs12317073; rs10770797; rs4140389; rs2306229; rs10770805; rs11830638; rs7967770; rs2041613; rs2417977; rs11045919; rs7970493; rs7964783; rs10841791; rs10770800; rs10841802; rs7957203; rs10770801; rs4762701; rs10841801; rs7967902; rs11836987; rs11045994; rs1993906; rs2045941; rs11834359; rs2061825; rs11834836; rs17333047; rs11833771; rs3764042; rs11834777; rs10841797; rs11045971; rs11046010; rs7316461; rs4762700; rs2215732; rs4337089; rs11830952; rs12809573; rs11831407; rs11045988; rs10459074; rs12826226; rs4148977; rs12099523; rs12809856; rs17333533; rs2192172; rs4762699; rs11045970; rs10770804; rs12581287; rs10743413; rs2306231; rs11046008; rs12833409; rs11830214; rs11045972; rs12301085; rs3764041; rs4762818; rs11045967; rs11045969; rs11837182; rs7954757; rs12810446; rs10841798; rs10841803; rs4115170; rs10841800; rs17681288; rs11045968; rs4442593; rs4762819; rs11045920; rs7312628; rs2045943; rs12303202; rs7959833; rs2219791; rs4078; rs7298982; rs10841799; rs7980167; rs17418255; rs10841804; rs12369820; rs11046000; rs10770802; rs12322242; rs2127116; rs11836617; rs12298237; rs11046012; rs34103511; rs11045997; rs11045986; rs2045942; rs9919685; rs1871289; rs12818296; rs10082739; rs2192173; rs4762816; rs11838314; rs12307592; rs7301895; rs2045939; rs17681255; rs12308945; rs2041612; rs10841796; rs11045995; rs9919728; rs12312939; rs7312451; rs12319891; rs3764043; rs11833926; rs7303788; rs11046001; rs12824228; rs2857468; rs12099524; rs12820524; rs7488533; rs2045940; rs7954751; rs11045998; rs11614319; rs11046007; rs764906; rs12823714; rs4762817; rs7980742; rs2306230; rs7960160; rs7313671; rs10770803; rs12818993; rs10459075; rs11046013; rs2219793; rs2417973; rs4149002; rs4148989; rs2169883; rs4148998; rs11045959; rs2417974; rs4148987; rs4148991; rs10841782; rs6487215; rs11045922; rs11045923; rs4148986; rs2417971; rs3764044; rs3751270; rs4149005; rs722994; rs7977517; rs7980842; rs7978981; rs7967354; rs10841794; rs2306227; rs11045960; rs4148993; rs7962263; rs7316412; rs3794320; rs10743411; rs4148999; rs6487216; rs7955581; rs7977483; rs2199686; rs2199684; rs11045944; rs7968331; rs7486475; rs6487217; rs7978322; rs4148992; rs7298793; rs16923663; rs11045978; rs7974575; rs7966334; rs7958005; rs11830939; rs16923597; rs7967303; rs10841789; rs7305911; rs10841786; rs3736080; rs7965059; rs16923647; rs11045974; rs10505872; rs4148984; rs11830367; rs11832394; rs2199685; rs7963398; rs12298817; rs11045980; rs2127117; rs11045953; rs4148990; rs11832851; rs4149003; rs11838023; rs10770796; rs11045962; rs11045946; rs7967935; rs11045975; rs4149001; rs4148988; rs16923623; rs4149000; rs12231212; rs11836396; rs11045948; rs4148996; rs11836945; rs11045942; rs3736081; rs2127118; rs11045930; rs4148995; rs11045958; rs11833627; rs12231738; rs7952736; rs2086194; rs11045945; rs12231484; rs4522218; rs11045954; rs7304940; rs11045961; rs11045950; rs7977652; rs7967403; rs2086193; rs10770795; rs11045931; rs10743412; rs4148994; rs11830971; rs11045924; rs4148982; rs11045976; rs11045957; rs7300463; rs12228765; rs4148997; rs10841783; rs4149004; rs7975612; rs12230401; rs10841790; rs7962919; rs11045952; rs2199687; rs11045926; rs10841784; rs7137014; rs4453284; rs12311809; rs11045965; rs7296472; rs7300346; rs11045932; rs2199683; rs12307908; rs12300594; rs7305484; rs12227319; rs10431251; rs2417972; rs12830245; rs11045934; rs11045955; rs11045921; rs2219792; rs4508253; rs4148985; rs12423510; rs2306226; rs11045933; rs11837357; rs10841787; rs4148983; rs11045956; rs11045925; rs16923608; rs2900480; rs4148981; rs11045927; rs11829484; rs11837359; rs7315667; rs7968842; rs4149008; rs12317843; rs11045917; rs11045918; rs4149006; rs12816792; rs4149009; rs12580098; rs7975594; rs3962563; rs41275204; rs11046009; rs12831290; rs34052201; rs7959775; rs12813247; rs12831653; rs12296154; rs12817281; rs11045999; rs35001636; rs34091985; rs12319570; rs12822994; rs41275202; rs35166807; rs10569114; rs12314592; rs35695485; rs33997554; rs12811254; rs11045984; rs35589853; rs36091983; rs12825593; rs12316436; rs12320968; rs3983535; rs4460854; rs11045990; rs28419468; rs34233148; rs11045996; rs34822370; rs35824274; rs11830993; rs11502680; rs34587587; rs11046004; rs12372118; rs11612222; rs12809265; rs11502681; rs35754317; rs12303996; rs28788610; rs4762820; rs12321375; rs12307186; rs34057845; rs7139223; rs12297072; rs11502426; rs11454466; rs35529364; rs12820826; rs7484455; rs35419909; rs35620370; rs35523483; rs35618589; rs11046006; rs1871288; rs4148979; rs34700187; rs12296813; rs35286038; rs35808554; rs11502425; rs35197974; rs12099528; rs12230953; rs5796898; rs11045992; rs12303719; rs11045993; rs35527094; rs12816889; rs4356287; rs7980490; rs36187285; rs34383451; rs34971713; rs3834939; rs36176879; rs35421887; rs12832693; rs3060709; rs4088; rs34365880; rs12369265; rs12303514; rs12824084; rs11045989; rs12816621; rs7306015; rs11397114; rs34486399; rs34754153; rs7138451; rs10691224; rs35145133; rs7978677; rs2857467; rs11046011; rs35884174; rs11045987; rs11046003; rs35940473; rs34241344; rs12830157; rs12161785; rs1979405; rs12316340; rs5796897; rs34758237; rs2306228; rs12099809; rs11045991; rs10641127; rs34744403; rs11611759; rs11831262; rs34363261; rs12809659; rs34362845; rs34249976; rs10679944; rs34639930; rs11494560; rs7980430; rs12309871; rs4148980; rs28848212; rs34223788; rs12809503; rs12423228; rs11831346; rs7977606; rs11513229; rs12303558; rs12809668; rs7134327; rs4149010; rs11834403; rs7134424; rs12833802; rs10633168; rs35901590; rs11410921; rs11045929; rs12809150; rs34696667; rs34601649; rs12829670; rs12303296; rs12830055; rs11045947; rs11832186; rs35277470; rs11561152; rs12368481; rs35809194; rs12822221; rs12810530; rs3830206; rs12366423; rs11045936; rs12369723; rs34663140; rs41275206; rs28803237; rs11045981; rs11045963; rs28391834; rs5796895; rs11045940; rs11831362; rs34738036; rs35997979; rs3833795; rs11533477; rs11559786; rs12367236; rs12298425; rs10636619; rs11045938; rs11045979; rs7307090; rs11045941; rs7488230; rs11535999; rs7974395; rs12366425; rs12369884; rs5796896; rs12810718; rs28851185; rs11045951; rs34022980; rs34699822; rs35461166; rs34909017; rs11045937; rs36089711; rs34211424; rs35385843; rs3838822; rs7486674; rs34720124; rs11834943; rs12829514; rs11831367; rs11045977; rs35099304; rs12367829; rs11045943; rs4149011; rs35621428; rs3060621; rs11502677; rs34875372; rs11045928; rs3060625; rs12824165; rs11502679; rs11535998; rs3060667; rs34082434; rs12423216; rs34242025; rs12306839; rs11045939; rs35736956; rs12296619; rs12809155; rs35202436; rs12820529; rs11536000; rs28802276; rs35667496; rs12314183; rs12312475; rs1000626; rs34009532; rs11045949; rs11313789; rs3060632; rs12824944; rs34756415; rs3060629; rs28504595; rs12230350; rs34439424; rs11045964; rs12820457; rs12322006; rs34124645; rs34765941; rs12300690; rs11045966; rs34889748; rs11537394; rs34636443; rs35244847; rs35429838; rs12821721; rs12809167; rs11045935; rs12809647; rs35059155; rs12307049; rs4149007; rs34400572; rs12320362; rs3830207; rs1056007; rs10841777; rs10841778; rs10841779; rs10841780; rs10841781; rs11045913; rs11045915; rs11045916; rs11046017; rs11519068; rs11568557; rs11568564; rs11568565; rs11568566; rs11568570; rs11568572; rs11568573; rs11568575; rs11568576; rs11568578; rs11568579; rs11836625; rs12300126; rs12305367; rs12306121; rs12306305; rs12308181; rs12308255; rs12313651; rs12315259; rs12319824; rs12581327; rs12811082; rs12824378; rs12826421; rs17680758; rs17680787; rs1800203; rs2041614; rs2199680; rs2219790; rs2417970; rs34417126; rs34996992; rs3794319; rs4267114; rs4762821; rs4762822; rs4762823; rs5482; rs5483; rs5484; rs5486; rs5487; rs5488; rs5489; rs7137767; rs7311964; rs7350579; rs7953750; rs7967339; rs875234

# Macromolecular_Interacting_Partner_17_General_References:
7557095; 10779507; 11238933

# Macromolecular_Interacting_Partner_17_References:
12130705; 16436656; 9328325

# Macromolecular_Interacting_Partner_18_ID:
7956

# Macromolecular_Interacting_Partner_18_Name:
Ileal sodium/bile acid cotransporter

# Macromolecular_Interacting_Partner_18_Synonyms:
Ileal Na(+/bile acid cotransporter; Na(+-dependent ileal bile acid transporter; Ileal sodium-dependent bile acid transporter; ISBT; IBAT; Apical sodium- dependent bile acid transporter; ASBT; Sodium/taurocholate cotransporting polypeptide, ileal; Solute carrier family 10 member 2

# Macromolecular_Interacting_Partner_18_Gene_Name:
SLC10A2

# Macromolecular_Interacting_Partner_18_Protein_Sequence:
>Ileal sodium/bile acid cotransporter
MNDPNSCVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLALVMFSMGCNVEIKKFLG
HIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAVVVLIIGCCPGGTASNILAYWVD
GDMDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSGSIVIPYDNIGTSLVALVVPVSIGM
FVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIAPKLWIIGTIFPVAGYSL
GFLLARIAGLPWYRCRTVAFETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAF
AAIFLGFYVAYKKCHGKNKAEIPESKENGTEPESSFYKANGGFQPDEK

# Macromolecular_Interacting_Partner_18_Number_of_Residues:
348

# Macromolecular_Interacting_Partner_18_Molecular_Weight:
37698

# Macromolecular_Interacting_Partner_18_Theoretical_pI:
7.13

# Macromolecular_Interacting_Partner_18_GO_Classification:
>>>
Function:  transporter activity
Function:  organic acid transporter activity
Function:  organic acid:sodium symporter activity
Function:  bile acid:sodium symporter activity
 ||
>>>
Process:  anion transport
Process:  organic anion transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  cation transport
Process:  monovalent inorganic cation transport
Process:  sodium ion transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_18_General_Function:
Not Available

# Macromolecular_Interacting_Partner_18_Specific_Function:
Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism

# Macromolecular_Interacting_Partner_18_Pathway:
Not Available

# Macromolecular_Interacting_Partner_18_Reaction:
Not Available

# Macromolecular_Interacting_Partner_18_Pfam_Domain_Function:
PF01758:SBF

# Macromolecular_Interacting_Partner_18_Signals:
None

# Macromolecular_Interacting_Partner_18_Transmembrane_Regions:
29-49
83-103
127-147
158-178
196-216
225-245
285-305

# Macromolecular_Interacting_Partner_18_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_18_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_18_GenBank_ID_Protein:
595399

# Macromolecular_Interacting_Partner_18_SwissProt_ID:
NTCP2_HUMAN (Q12908)

# Macromolecular_Interacting_Partner_18_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_18_Genecard_id:
SLC10A2

# Macromolecular_Interacting_Partner_18_Geneatlas_id:
SLC10A2

# Macromolecular_Interacting_Partner_18_hgnc_id:
HGNC:10906

# Macromolecular_Interacting_Partner_18_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_18_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_18_Gene_Sequence:
>1047 bp
ATGAATGATCCGAACAGCTGTGTGGACAATGCAACAGTTTGCTCTGGTGCATCCTGTGTG
GTACCTGAGAGCAATTTCAATAACATCCTAAGTGTGGTCCTAAGTACGGTGCTGACCATC
CTGTTGGCCTTGGTGATGTTCTCCATGGGATGCAACGTGGAAATCAAGAAATTTCTAGGG
CACATAAAGCGGCCGTGGGGCATTTGTGTTGGCTTCCTCTGTCAGTTTGGAATCATGCCC
CTCACAGGATTCATCCTGTCGGTGGCCTTTGACATCCTCCCGCTCCAGGCCGTAGTGGTG
CTCATTATAGGATGCTGCCCTGGAGGAACTGCCTCCAATATCTTGGCCTATTGGGTCGAT
GGCGACATGGACCTGAGCGTCAGCATGACCACATGCTCCACACTGCTTGCCCTCGGAATG
ATGCCGCTGTGCCTCCTTATCTATACCAAAATGTGGGTCGACTCTGGGAGCATCGTAATT
CCCTATGATAACATAGGTACATCTCTGGTTGCTCTCGTTGTTCCTGTTTCCATTGGAATG
TTTGTTAATCACAAATGGCCCCAAAAAGCAAAGATCATACTTAAAATTGGGTCCATCGCG
GGCGCCATCCTCATTGTGCTCATAGCTGTGGTTGGAGGAATATTGTACCAAAGCGCCTGG
ATCATTGCTCCCAAACTGTGGATTATAGGAACAATATTTCCTGTGGCGGGTTACTCCCTG
GGGTTTCTTCTGGCTAGAATTGCTGGTCTACCCTGGTACAGGTGCCGAACGGTTGCTTTT
GAAACGGGGATGCAGAACACGCAGCTATGTTCCACCATCGTTCAGCTCTCCTTCACTCCT
GAGGAGCTCAATGTCGTATTCACCTTCCCGCTCATCTACAGCATTTTCCAGCTCGCCTTT
GCCGCAATATTCTTAGGATTTTATGTGGCATACAAGAAATGTCATGGAAAAAACAAGGCA
GAAATTCCAGAGAGCAAAGAAAATGGAACGGAGCCAGAGTCATCGTTTTATAAGGCAAAT
GGAGGATTTCAACCTGACGAAAAGTAG

# Macromolecular_Interacting_Partner_18_GenBank_ID_Gene:
U10417

# Macromolecular_Interacting_Partner_18_Chromosome_Location:
Chromosome:13

# Macromolecular_Interacting_Partner_18_Locus:
13q33

# Macromolecular_Interacting_Partner_18_SNPs:
rs188096; rs157381; rs279941; rs2301159; rs7987433; rs2301157; rs279942; rs16961281; rs3803258; rs279913; rs166833; rs169459; rs157266; rs397268; rs190716; rs183965; rs1886925; rs183963; rs182195; rs279916; rs279914; rs279939; rs279940; rs9300782; rs279917; rs9300784; rs1329515; rs7324197; rs9514092; rs279915; rs9300783; rs7330748; rs9554932; rs279936; rs1854519; rs279912; rs8000956; rs279937; rs7992777; rs4772525; rs16961277; rs9518912; rs696914; rs9557997; rs16961271; rs9514089; rs9586056; rs279938; rs3783238; rs17274342; rs9557994; rs9557996; rs9514091; rs1863441; rs2765583; rs16961268; rs9518913; rs157380; rs17274080; rs10508101; rs279919; rs9518915; rs9582652; rs7324008; rs696915; rs1863444; rs2567774; rs1925978; rs279920; rs9554931; rs7323231; rs1863442; rs9518914; rs7330697; rs17275126; rs9554933; rs12322975; rs9582653; rs1329516; rs3783239; rs9586057; rs11839892; rs17334872; rs1863443; rs457831; rs17273914; rs16961276; rs7324650; rs16961178; rs7139937; rs3753007; rs1886926; rs7323835; rs9300785; rs7337216; rs3837573; rs9557998; rs7330346; rs17273935; rs9514093; rs9586052; rs455925; rs157382; rs3759503; rs3759504; rs7990819; rs9582654; rs9582655; rs7335602; rs12018021; rs16961295; rs157268; rs279935; rs16961285; rs41281678; rs41281680; rs28544361; rs1977488; rs2301158; rs3034259; rs3216781; rs35033949; rs41281676; rs41281682; rs1977489; rs9586053; rs5806337; rs9518909; rs1854520; rs35359827; rs9586055; rs34157445; rs36055220; rs34163791; rs3837572; rs34542141; rs35597421; rs3216821; rs10688538; rs7321830; rs9652098; rs35097190; rs149455; rs35521067; rs35661595; rs11311257; rs9518910; rs34390008; rs413834; rs10695927; rs33930404; rs10644872; rs11408919; rs9586054; rs9514086; rs35462298; rs460577; rs2148161; rs279918; rs3831178; rs35629811; rs11336918; rs456794; rs28587191; rs9557995; rs35548160; rs9518911; rs34429788; rs34206110; rs34241706; rs9557992; rs3759501; rs3759502; rs34919736; rs9586058; rs28548218; rs1005976; rs10508099; rs10508100; rs11618082; rs11840747; rs11841179; rs11843134; rs12873753; rs1365194; rs1549836; rs1571513; rs157383; rs16961116; rs16961307; rs16961311; rs1886927; rs2390845; rs2567775; rs279933; rs6491728; rs6491729; rs696913; rs7319981; rs7329636; rs7986408; rs7992775; rs9514085; rs9518916; rs9582650; rs9582651; rs9586059; rs994720

# Macromolecular_Interacting_Partner_18_General_References:
7592981; 9109432; 12364586; 11589382

# Macromolecular_Interacting_Partner_18_References:
11447228; 15209631; 15834929; 16256913

# Macromolecular_Interacting_Partner_19_ID:
8049

# Macromolecular_Interacting_Partner_19_Name:
Sodium/bile acid cotransporter

# Macromolecular_Interacting_Partner_19_Synonyms:
Na(+/bile acid cotransporter; Na(+/taurocholate transport protein; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1; Cell growth-inhibiting gene 29 protein

# Macromolecular_Interacting_Partner_19_Gene_Name:
SLC10A1

# Macromolecular_Interacting_Partner_19_Protein_Sequence:
>Sodium/bile acid cotransporter
MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKG
LAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLSI
VMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKR
PQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVL
SALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLL
IAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA

# Macromolecular_Interacting_Partner_19_Number_of_Residues:
349

# Macromolecular_Interacting_Partner_19_Molecular_Weight:
38120

# Macromolecular_Interacting_Partner_19_Theoretical_pI:
8.94

# Macromolecular_Interacting_Partner_19_GO_Classification:
>>>
Function:  transporter activity
Function:  organic acid transporter activity
Function:  organic acid:sodium symporter activity
Function:  bile acid:sodium symporter activity
 ||
>>>
Process:  anion transport
Process:  organic anion transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  cation transport
Process:  monovalent inorganic cation transport
Process:  sodium ion transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_19_General_Function:
Not Available

# Macromolecular_Interacting_Partner_19_Specific_Function:
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium

# Macromolecular_Interacting_Partner_19_Pathway:
Not Available

# Macromolecular_Interacting_Partner_19_Reaction:
Not Available

# Macromolecular_Interacting_Partner_19_Pfam_Domain_Function:
PF01758:SBF

# Macromolecular_Interacting_Partner_19_Signals:
None

# Macromolecular_Interacting_Partner_19_Transmembrane_Regions:
25-45
60-80
91-111
120-140
156-176
191-211
220-240
283-303

# Macromolecular_Interacting_Partner_19_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_19_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_19_GenBank_ID_Protein:
410214

# Macromolecular_Interacting_Partner_19_SwissProt_ID:
NTCP_HUMAN (Q14973)

# Macromolecular_Interacting_Partner_19_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_19_Genecard_id:
SLC10A1

# Macromolecular_Interacting_Partner_19_Geneatlas_id:
SLC10A1

# Macromolecular_Interacting_Partner_19_hgnc_id:
HGNC:10905

# Macromolecular_Interacting_Partner_19_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_19_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_19_Gene_Sequence:
>1050 bp
ATGGAGGCCCACAACGCGTCTGCCCCATTCAACTTCACCCTGCCACCCAACTTTGGCAAG
CGCCCCACAGACCTGGCACTGAGCGTCATCCTGGTGTTCATGTTGTTCTTCATCATGCTC
TCGCTGGGCTGCACCATGGAGTTCAGCAAGATCAAGGCTCACTTATGGAAGCCTAAAGGG
CTGGCCATCGCCCTGGTGGCACAGTATGGCATCATGCCCCTCACGGCCTTTGTGCTGGGC
AAGGTCTTCCGGCTGAAGAACATTGAGGCACTGGCCATCTTGGTCTGTGGCTGCTCACCT
GGAGGGAACCTGTCCAATGTCTTCAGTCTGGCCATGAAGGGGGACATGAACCTCAGCATT
GTGATGACCACCTGCTCCACCTTCTGTGCCCTTGGCATGATGCCTCTCCTCCTGTACATC
TACTCCAGGGGGATCTATGATGGGGACCTGAAGGACAAGGTGCCCTATAAAGGCATCGTG
ATATCACTGGTCCTGGTTCTCATTCCTTGCACCATAGGGATCGTCCTCAAATCCAAACGG
CCACAATACATGCGCTATGTCATCAAGGGAGGGATGATCATCATTCTCTTGTGCAGTGTG
GCCGTCACAGTTCTCTCTGCCATCAATGTGGGGAAGAGCATCATGTTTGCCATGACACCA
CTCTTGATTGCCACCTCCTCCCTGATGCCTTTTATTGGCTTTCTGCTGGGTTATGTTCTC
TCTGCTCTCTTCTGCCTCAATGGACGGTGCAGACGCACTGTCAGCATGGAGACTGGATGC
CAAAATGTCCAACTCTGTTCCACCATCCTCAATGTGGCCTTTCCACCTGAAGTCATTGGA
CCACTTTTCTTCTTTCCCCTCCTCTACATGATTTTCCAGCTTGGAGAAGGGCTTCTCCTC
ATTGCCATATTTTGGTGCTATGAGAAATTCAAGACTCCCAAGGATAAAACAAAAATGATC
TACACAGCTGCCACAACTGAAGAAACAATTCCAGGAGCTCTGGGAAATGGCACCTACAAA
GGGGAGGACTGCTCCCCTTGCACAGCCTAG

# Macromolecular_Interacting_Partner_19_GenBank_ID_Gene:
L21893

# Macromolecular_Interacting_Partner_19_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_19_Locus:
14q24.1

# Macromolecular_Interacting_Partner_19_SNPs:
rs2296651; rs4646285; rs10130174; rs4646286; rs943277; rs9944036; rs11624523; rs11849924; rs11626135; rs2332167; rs11621916; rs17556915; rs11622925; rs3784152; rs11624532; rs9323529; rs10146486; rs12434773; rs10145643; rs10142031; rs4646295; rs17107282; rs10142027; rs10137162; rs17107278; rs10459536; rs4646287; rs3784153; rs8022592; rs10134553; rs8020042; rs10146088; rs8011311; rs4646296; rs7154439; rs4646297; rs2148505; rs11628646; rs11623504; rs11628755; rs11845658; rs36098664; rs943276; rs28437822; rs35445784; rs3837669; rs10145650; rs35397817; rs35334890; rs10559679; rs4646290; rs34996682; rs4646289; rs4646294; rs8020504; rs35327778; rs11390058; rs34656743; rs3784154; rs35733530; rs35730433; rs35355208; rs35402952; rs11626064; rs34462658; rs36115704; rs10130124; rs10552156; rs3837667; rs34966619; rs34708301; rs35161261; rs10567834; rs28633309; rs28445972; rs28595072; rs10697796; rs10601222; rs35904913; rs11628839; rs35679376; rs34508610; rs10560156; rs10130926; rs10146537; rs1057683; rs1058081; rs12431573; rs12431979; rs12882299; rs1802832; rs1952204; rs1958085; rs2148504; rs2332168; rs2877597; rs3104; rs3105; rs34496118; rs3809399; rs6573908; rs7147944; rs7159823; rs8006833; rs8013586; rs8013598; rs8014019; rs8019166; rs8019999

# Macromolecular_Interacting_Partner_19_General_References:
8132774

# Macromolecular_Interacting_Partner_19_References:
10640286; 11352825; 12065290; 12510858

# Macromolecular_Interacting_Partner_20_ID:
7747

# Macromolecular_Interacting_Partner_20_Name:
AN1, ubiquitin-like, homolog

# Macromolecular_Interacting_Partner_20_Synonyms:
Xenopus laevis

# Macromolecular_Interacting_Partner_20_Gene_Name:
ANUBL1

# Macromolecular_Interacting_Partner_20_Protein_Sequence:
>AN1, ubiquitinlike, homolog
MDNRKEPPFFNDDNMGPFYYRLHFCDTMELFIETLTGTCFELRVSPFETVISVKAKIRRL
EGIPICRQHLIWNNMELENDYCLNDYNISEGCTLKLVLAMRGGPINTRRDLQIPR

# Macromolecular_Interacting_Partner_20_Number_of_Residues:
115

# Macromolecular_Interacting_Partner_20_Molecular_Weight:
13565

# Macromolecular_Interacting_Partner_20_Theoretical_pI:
5.74

# Macromolecular_Interacting_Partner_20_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_20_General_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Pathway:
Not Available

# Macromolecular_Interacting_Partner_20_Reaction:
Not Available

# Macromolecular_Interacting_Partner_20_Pfam_Domain_Function:
PF00240:ubiquitin

# Macromolecular_Interacting_Partner_20_Signals:
None

# Macromolecular_Interacting_Partner_20_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_20_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_20_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_20_GenBank_ID_Protein:
55665296

# Macromolecular_Interacting_Partner_20_SwissProt_ID:
Q5VVY2_HUMAN (Q5VVY2)

# Macromolecular_Interacting_Partner_20_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_20_Genecard_id:
ANUBL1

# Macromolecular_Interacting_Partner_20_Geneatlas_id:
ANUBL1

# Macromolecular_Interacting_Partner_20_hgnc_id:
HGNC:23504

# Macromolecular_Interacting_Partner_20_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_20_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_20_Gene_Sequence:
>2184 bp
ATGGATAACAGAAAAGAGCCTCCATTCTTCAATGATGATAACATGGGACCATTTTACTAC
AGACTTCATTTCTGTGATACCATGGAGCTCTTCATTGAAACATTAACTGGAACATGTTTT
GAGCTGAGAGTTTCACCTTTTGAAACTGTTATTTCTGTGAAAGCAAAAATTCGAAGATTG
GAAGGTATTCCCATCTGTCGACAACACTTAATTTGGAATAACATGGAACTTGAAAATGAT
TATTGCTTGAATGATTACAACATTTCAGAAGGGTGTACCTTGAAGCTAGTTTTGGCTATG
CGTGGCGGACCTATAAATACTAGAAGAGTTCCTACAGACGATCCACTTAGGAAGATGGCA
GAGTACTTGGATTCCAGTCGAGTTGAGGTCTGGGAGAAGACCTCCTGCAGCAAACAAGTT
ACATTTTTGGTATACCAAGAAGGAGATCAATTGAATTTCTTTCCTGCAGTAGATAGGGGA
GATGGCACTTTAACACCGTTATCTGACTCTTCAAAGAAAATAGATTTTCATTTGCATGTC
CTACGGAGAAAAGGAGAACATCGTATGAGTGGTGGTTCTATGTATAATTCAGATACAGAT
GAGGATGAAGAAACTGAGCCTTCTTCTTCTGGGCAACAGATAATTGAAAATTCAATAACT
ATGAATAAGATGAAGCTGCTGAAGGCTAAGATGAAGAACATGAATCTCAGCAAAAAGCCT
AAGAAAGCTGTCAAGATAAAACCTCACCCACCTGTAGCTCCTCGACCTTCTAGTGGTTCC
ACTGCACCATCTCGCCACCGATTGTTAAGGGTCCTCCCCAACATTGGTCAATCTTGTTCA
CCTGCTTTTGGGAATGCATATCCGCCCGAAATCTCCAGGAATGGAATTTCAAGTTTGGCA
ACTCAACTCTCTGCTGAGAGATACATATCTTCTATCACTGGTGAATTTCTTAAGGAAGAT
AATAGCTGGGAGAATAACACACTGTCTCACTTCAGTAGCAACGTCAAACTACCTCCTCAG
ATACCCCATTTGGAGTTGGGAAATGACCAGGAGCTTGCTGACTCTGTTCTCCATCTTGGA
TCATCCCTGCCTAGGCAAACAAAACATTTTTTAGGAAACTTGCCATCTAGTAATGGGAAC
ATTGTCTTACCTTCAGAAGAATGTGTAACCGAACAATCACTTCTACCTAAAGTGGGCTCA
CTGGCTTCATTTGCAGAAGGAAATGCTGATGAACAGAGCAGCGGCTTAGAAGGTGCGTGC
AAAGTGAATCTGGAGTTGCTACTCACTAATGCTGACAAAGGGTTGAAAGCTCCAGAGCAG
CATCTCAAGCATGTTGCAGGAGTGCTGAATGGGGAATCAGTAGAGACTTCAGTTCTTAAC
TACCGGGAATTAAGTCCTCACAAGAATAGACTCTTGTCACCTCTTCGCTGTTCTGCACCA
ATGTCGCTACATAATTCTCTGGTGAAACCAGAGAGACAGTCCAAATGTTTTGAGTTTGGG
AAGCTACAGCCTTCTTCTTCTCAGTCACTGGATGTTCAAAACATAACTGATTCTTCTTTC
TCTAGGACTACTTGCTTTCAAGGTGTTAAAGTTGATTCACTTGGGAAAAGATCTGATGTT
ATTTCCAAAGTTGAGGCTCGGGATATCACAGAAATGACTAACAAGGCTTCCAAAGAGCCT
GTTGGTTGTGTAAATAATATCAGTTTTCTTGCCTCACTGGCCGGGAGCACAAGCAGAAAT
AGATTACAGAGCACACGTGGGGCAGGCAGGCTTCAGAACTCTGGAACTGGGCTGTCTACA
AACCTCCAGCATTTTCAGGAAGAAAACTTTAGGAAAAGTTCTCCCCAGTTAGAACATACA
GGAGTTTTTTTGTCTACCCATGGTGTTGGAATGAATGGAAATAATGCAGCAGCAGGGAAA
AGCGTAGGAGAATGTACTACTCATCACCTCCCACCTGTGAAAGCCCCTCTTCAGACAAAG
AAGAAAACAACAAATCATTGTTTTCTTTGTGGAAAGAAAACAGGACTGGCTAGTAGCTAC
GAATGCAGATGTGGAAACAACTTCTGTGCATCTCATCGTTATGCAGAAACTCATGGCTGT
ACCTATGATTACAAGAGTGCAGGGAGGAGATACTTGCACGAGGCAAATCCTGTGGTTAAT
GCACCAAAGCTTCCAAAAATCTAA

# Macromolecular_Interacting_Partner_20_GenBank_ID_Gene:
AL445201

# Macromolecular_Interacting_Partner_20_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_20_Locus:
10q11.21

# Macromolecular_Interacting_Partner_20_SNPs:
rs17854567; rs12267385; rs1060848; rs7069223; rs11528544; rs11592630; rs4949013; rs10751387; rs11239577; rs10900232; rs17768650; rs17157945; rs10751386; rs7074524; rs17696005; rs10793621; rs2305299; rs7091141; rs11239585; rs17768692; rs10793622; rs17157941; rs12766066; rs11239586; rs10900229; rs12764555; rs11239580; rs7087287; rs10900230; rs11239587; rs17157944; rs17696011; rs11239582; rs10751385; rs12778159; rs10900231; rs11592669; rs7898761; rs3802543; rs3739965; rs17857362; rs41299230; rs34082391; rs35142284; rs41314982; rs35101253; rs17854568; rs4949014; rs2926329; rs34048645; rs11492889; rs34938900; rs7920461; rs2926327; rs41313826; rs2926328; rs12240731; rs35219365; rs34187732; rs34028441; rs11239583; rs9422661; rs35859169; rs1201436; rs2923044; rs34671659; rs35601286; rs41301629; rs12774796; rs12247223; rs34853665; rs41301631; rs35337666; rs12778934; rs11239576; rs11362238; rs35415235; rs11819162; rs35229531; rs12778943; rs28587306; rs34624161; rs9703030; rs34048465; rs34923160; rs35721167; rs7089133; rs1072929; rs10736836; rs11239584; rs35873337; rs11446488; rs35106684; rs7086332; rs11239579; rs34406643; rs34034843; rs41301627; rs34763590; rs1075000; rs28867788; rs7096342; rs12245469; rs12354709; rs35599803; rs12778926; rs12776675; rs34576059; rs35979489; rs33997594; rs11239578; rs11239581; rs12356629; rs3824617; rs34305372; rs41301625; rs35228493; rs10751384; rs11239574; rs11239575; rs3802542; rs4418752; rs7091808; rs7100819

# Macromolecular_Interacting_Partner_20_General_References:
Not Available

# Macromolecular_Interacting_Partner_20_References:
10209268; 11470901; 17134679; 8223945

# Macromolecular_Interacting_Partner_21_ID:
8025

# Macromolecular_Interacting_Partner_21_Name:
CDNA FLJ16580 fis, clone TESTI2050780

# Macromolecular_Interacting_Partner_21_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_21_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_21_Protein_Sequence:
>CDNA FLJ16580 fis, clone TESTI2050780
MFVGVARHSGSQDEVSRGVEPLDAARAQPAKDRRAKGTPKSSKPGKKHRYLRLLPEALIR
FGGFRKRKKAKSSVSKKPGEVDDSLEQPCGLGCLVSTCCECCNNIRCFMIFYCILLICQG
VVFGLIDVSIGDFQKEYQLKTIEKLALEKSYDISSGLVAIFIAFYGDRKKVIWFVASSFL
IGLGSLLCAFPSINEENKQSKVGIEGIAECTSMIGYALGYVLGAPLVKVPENTTSATKTG
KLGNLTAPCNEKCRCSSSIYSSICGRDDIEYFSPCFAGCTYSKAQNQKKMYYNCSCIKEG
LITADAEGDFIDARPGKCDAKCYKLPLFIAFIFSTLIFSGFSGVPIVLAMTRVVPDKLRS
LALGVSYVILRIFGTIPGPSIFKMSGETSCILRDVNKCGHRGRCWIYNKTKMAFLLVGIC
FLCKLCTIIFTTIAFFIYKRRLNENTDFPDVTVKNPKVKKKEETDL

# Macromolecular_Interacting_Partner_21_Number_of_Residues:
466

# Macromolecular_Interacting_Partner_21_Molecular_Weight:
51454

# Macromolecular_Interacting_Partner_21_Theoretical_pI:
9.06

# Macromolecular_Interacting_Partner_21_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_21_General_Function:
Not Available

# Macromolecular_Interacting_Partner_21_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_21_Pathway:
Not Available

# Macromolecular_Interacting_Partner_21_Reaction:
Not Available

# Macromolecular_Interacting_Partner_21_Pfam_Domain_Function:
PF07648:Kazal_2;
PF03137:OATP

# Macromolecular_Interacting_Partner_21_Signals:
None

# Macromolecular_Interacting_Partner_21_Transmembrane_Regions:
108-130; 171-193; 327-349; 415-437

# Macromolecular_Interacting_Partner_21_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_21_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_21_GenBank_ID_Protein:
47077405

# Macromolecular_Interacting_Partner_21_SwissProt_ID:
Q6ZMY5_HUMAN (Q6ZMY5)

# Macromolecular_Interacting_Partner_21_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_21_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_21_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_21_hgnc_id:
HGNC:23613

# Macromolecular_Interacting_Partner_21_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_21_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_21_Gene_Sequence:
>1401 bp
ATGTTCGTAGGCGTCGCCCGGCACTCTGGGAGCCAGGATGAAGTCTCAAGGGGAGTAGAG
CCGCTGGATGCCGCGCGGGCCCAGCCTGCTAAGGACAGGAGGGCCAAGGGAACCCCGAAG
TCCTCGAAGCCCGGGAAAAAACACCGGTATCTGAGACTACTTCCAGAGGCCTTGATAAGG
TTCGGCGGTTTCCGAAAAAGGAAAAAAGCCAAGTCCTCAGTTTCCAAGAAGCCGGGAGAA
GTGGATGACAGTTTGGAGCAGCCCTGTGGTTTGGGCTGCTTAGTCAGCACCTGCTGTGAG
TGTTGCAATAACATTCGCTGCTTCATGATTTTCTACTGCATCCTGCTCATATGTCAAGGT
GTGGTGTTTGGTCTTATAGATGTCAGCATTGGCGATTTTCAGAAGGAATATCAACTGAAA
ACCATTGAGAAGTTGGCATTGGAAAAGAGTTACGATATTTCATCTGGCCTGGTAGCAATA
TTTATAGCATTCTATGGAGACAGAAAAAAAGTAATATGGTTTGTAGCTTCCTCTTTTTTA
ATAGGACTTGGATCACTTTTATGTGCTTTTCCATCCATTAATGAAGAAAATAAACAAAGT
AAGGTAGGAATTGAAGGTATTGCAGAATGTACATCAATGATTGGATATGCTCTGGGTTAT
GTGCTAGGAGCACCACTAGTTAAAGTCCCTGAGAATACTACTTCTGCAACAAAAACAGGG
AAGTTGGGAAACCTCACGGCTCCTTGCAATGAAAAATGTAGATGCTCATCTTCAATTTAT
TCTTCTATATGTGGAAGAGATGATATTGAATATTTTTCTCCCTGCTTTGCAGGGTGTACA
TATTCTAAAGCACAAAACCAAAAAAAGATGTACTACAATTGTTCTTGCATTAAAGAAGGA
TTAATAACTGCAGATGCAGAAGGTGATTTTATTGATGCCAGACCCGGGAAATGTGATGCA
AAGTGCTATAAGTTACCTTTGTTCATTGCTTTTATCTTTTCTACACTTATATTTTCTGGT
TTTTCTGGTGTACCAATCGTCTTGGCCATGACGCGGGTTGTACCTGACAAACTGCGTTCT
CTGGCCTTGGGTGTAAGCTATGTGATTTTGAGAATATTTGGGACTATTCCTGGACCATCA
ATCTTTAAAATGTCAGGAGAAACTTCTTGTATTTTACGGGATGTTAATAAATGTGGACAC
AGAGGACGTTGTTGGATATATAACAAGACAAAAATGGCTTTCTTATTGGTAGGAATATGT
TTTCTTTGCAAACTATGCACTATCATCTTCACTACTATTGCATTTTTCATATACAAACGT
CGTCTAAATGAGAACACTGACTTCCCAGATGTAACTGTGAAGAATCCAAAAGTTAAGAAA
AAAGAAGAAACTGACTTGTAA

# Macromolecular_Interacting_Partner_21_GenBank_ID_Gene:
AK131445

# Macromolecular_Interacting_Partner_21_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_21_Locus:
Not Available

# Macromolecular_Interacting_Partner_21_SNPs:
Not Available

# Macromolecular_Interacting_Partner_21_General_References:
Not Available

# Macromolecular_Interacting_Partner_21_References:
8768705; 9928634

# Macromolecular_Interacting_Partner_22_ID:
7838

# Macromolecular_Interacting_Partner_22_Name:
PACAP protein

# Macromolecular_Interacting_Partner_22_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_22_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_22_Protein_Sequence:
>PACAP protein
MVTGGPWPTRLSRTCLHYLGEFGEDQIYEAHQQGRGALEALLCGGPQGACSEKVSATREE
L

# Macromolecular_Interacting_Partner_22_Number_of_Residues:
61

# Macromolecular_Interacting_Partner_22_Molecular_Weight:
6606

# Macromolecular_Interacting_Partner_22_Theoretical_pI:
4.92

# Macromolecular_Interacting_Partner_22_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_22_General_Function:
Not Available

# Macromolecular_Interacting_Partner_22_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_22_Pathway:
Not Available

# Macromolecular_Interacting_Partner_22_Reaction:
Not Available

# Macromolecular_Interacting_Partner_22_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_22_Signals:
None

# Macromolecular_Interacting_Partner_22_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_22_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_22_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_22_GenBank_ID_Protein:
31455257

# Macromolecular_Interacting_Partner_22_SwissProt_ID:
Q7Z6N2_HUMAN (Q7Z6N2)

# Macromolecular_Interacting_Partner_22_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_22_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_22_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_22_hgnc_id:
Not Available

# Macromolecular_Interacting_Partner_22_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_22_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_22_Gene_Sequence:
>186 bp
ATGGTCACAGGGGGCCCCTGGCCTACCAGGCTCTCCAGGACATGTTTGCACTACTTGGGG
GAGTTTGGAGAAGACCAGATCTATGAAGCCCACCAACAAGGCCGAGGGGCTCTGGAGGCA
TTGCTATGTGGGGGACCCCAGGGGGCCTGCTCAGAGAAGGTGTCAGCCACAAGAGAAGAG
CTCTAG

# Macromolecular_Interacting_Partner_22_GenBank_ID_Gene:
BC009931

# Macromolecular_Interacting_Partner_22_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_22_Locus:
Not Available

# Macromolecular_Interacting_Partner_22_SNPs:
Not Available

# Macromolecular_Interacting_Partner_22_General_References:
12477932

# Macromolecular_Interacting_Partner_22_References:
15646343; 15702783

# Macromolecular_Interacting_Partner_23_ID:
8766

# Macromolecular_Interacting_Partner_23_Name:
Solute carrier organic anion transporter family member 4A1

# Macromolecular_Interacting_Partner_23_Synonyms:
Solute carrier family 21 member 12; Sodium-independent organic anion transporter E; Organic anion-transporting polypeptide E; OATP-E; Colon organic anion transporter; Organic anion transporter polypeptide-related protein 1; OATP-RP1; OATPRP1; POAT

# Macromolecular_Interacting_Partner_23_Gene_Name:
SLCO4A1

# Macromolecular_Interacting_Partner_23_Protein_Sequence:
>Solute carrier organic anion transporter family member 4A1
MPLHQLGDKPLTFPSPNSAMENGLDHTPPSRRASPGTPLSPGSLRSAAHSPLDTSKQPLC
QLWAEKHGARGTHEVRYVSAGQSVACGWWAFAPPCLQVLNTPKGILFFLCAAAFLQGMTV
NGFINTVITSLERRYDLHSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLLM
GTGSLVFALPHFTAGRYEVELDAGVRTCPANPGAVCADSTSGLSRYQLVFMLGQFLHGVG
ATPLYTLGVTYLDENVKSSCSPVYIAIFYTAAILGPAAGYLIGGALLNIYTEMGRRTELT
TESPLWVGAWWVGFLGSGAAAFFTAVPILGYPRQLPGSQRYAVMRAAEMHQLKDSSRGEA
SNPDFGKTIRDLPLSIWLLLKNPTFILLCLAGATEATLITGMSTFSPKFLESQFSLSASE
AATLFGYLVVPAGGGGTFLGGFFVNKLRLRGSAVIKFCLFCTVVSLLGILVFSLHCPSVP
MAGVTASYGGSLLPEGHLNLTAPCNAACSCQPEHYSPVCGSDGLMYFSLCHAGCPAATET
NVDGQKVYRDCSCIPQNLSSGFGHATAGKCTSTCQRKPLLLVFIFVVIFFTFLSSIPALT
ATLRCVRDPQRSFALGIQWIVVRILGGIPGPIAFGWVIDKACLLWQDQCGQQGSCLVYQN
SAMSRYILIMGLLYKVLGVLFFAIACFLYKPLSESSDGLETCLPSQSSAPDSATDSQLQS
SV

# Macromolecular_Interacting_Partner_23_Number_of_Residues:
722

# Macromolecular_Interacting_Partner_23_Molecular_Weight:
77194

# Macromolecular_Interacting_Partner_23_Theoretical_pI:
7.85

# Macromolecular_Interacting_Partner_23_GO_Classification:
>>>
 Function:  transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_23_General_Function:
Not Available

# Macromolecular_Interacting_Partner_23_Specific_Function:
Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate

# Macromolecular_Interacting_Partner_23_Pathway:
Not Available

# Macromolecular_Interacting_Partner_23_Reaction:
Not Available

# Macromolecular_Interacting_Partner_23_Pfam_Domain_Function:
PF07648:Kazal_2
PF03137:OATP

# Macromolecular_Interacting_Partner_23_Signals:
1-188

# Macromolecular_Interacting_Partner_23_Transmembrane_Regions:
104-124
144-164
172-192
229-249
263-283
309-329
372-392
424-444
454-474
579-599
617-637
667-687

# Macromolecular_Interacting_Partner_23_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_23_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_23_GenBank_ID_Protein:
6683743

# Macromolecular_Interacting_Partner_23_SwissProt_ID:
SO4A1_HUMAN (Q96BD0)

# Macromolecular_Interacting_Partner_23_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_23_Genecard_id:
SLCO4A1

# Macromolecular_Interacting_Partner_23_Geneatlas_id:
SLCO4A1

# Macromolecular_Interacting_Partner_23_hgnc_id:
HGNC:10953

# Macromolecular_Interacting_Partner_23_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_23_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_23_Gene_Sequence:
>2169 bp
ATGCCCCTGCATCAGCTGGGGGACAAGCCGCTCACCTTCCCCAGCCCCAACTCAGCCATG
GAAAACGGGCTTGACCACACCCCACCCAGCAGGAGGGCATCCCCGGGCACACCCCTGAGC
CCCGGCTCCCTCCGCTCCGCTGCCCATAGCCCCCTGGACACCAGCAAGCAGCCCCTCTGC
CAGCTCTGGGCCGAGAAGCATGGCGCCCGGGGGACCCATGAGGTGCGGTACGTCTCGGCC
GGGCAGAGCGTGGCGTGCGGCTGGTGGGCCTTCGCACCGCCGTGCCTGCAGGTCCTCAAC
ACGCCCAAGGGCATCCTGTTCTTCCTGTGTGCGGCCGCATTCCTGCAGGGGATGACTGTG
AATGGCTTCATCAACACAGTCATCACCTCCCTGGAGCGCCGCTATGACCTGCACAGCTAC
CAGAGCGGGCTCATCGCCAGCTCCTACGACATTGCCGCCTGCCTCTGCCTCACCTTCGTC
AGCTACTTCGGGGGCTCAGGGCACAAGCCGCGCTGGCTGGGCTGGGGCGTGCTGCTTATG
GGCACGGGGTCGCTGGTGTTCGCGCTGCCCCACTTCACGGCTGGCCGCTATGAGGTGGAG
TTGGACGCGGGTGTCAGGACGTGCCCTGCCAACCCCGGCGCGGTGTGTGCGGACAGCACC
TCGGGCCTGTCCCGCTACCAGCTGGTCTTCATGCTGGGCCAGTTCCTGCATGGCGTGGGT
GCCACACCCCTCTACACGCTGGGCGTCACCTACCTGGATGAGAACGTCAAGTCCAGCTGC
TCGCCCGTCTACATTGCCATCTTCTACACAGCGGCCATCCTGGGCCCAGCTGCCGGCTAC
CTGATTGGAGGTGCCCTGCTGAATATCTACACGGAAATGGGCCGACGGACGGAGCTGACC
ACCGAGAGCCCACTGTGGGTCGGCGCCTGGTGGGTCGGCTTCCTGGGCTCTGGGGCCGCT
GCTTTCTTCACCGCCGTTCCCATCCTTGGTTACCCTCGGCAGCTGCCAGGCTCCCAGCGC
TACGCGGTCATGAGAGCGGCGGAAATGCACCAGTTGAAGGACAGCAGCCGTGGGGAGGCG
AGCAACCCGGACTTTGGGAAAACCATCAGAGACCTGCCTCTCTCCATCTGGCTCCTGCTG
AAGAACCCCACGTTCATCCTGCTCTGCCTGGCCGGGGCCACCGAGGCCACTCTCATCACC
GGCATGTCCACGTTCAGCCCCAAGTTCTTGGAGTCCCAGTTCAGCCTGAGTGCCTCAGAA
GCTGCCACCTTGTTTGGGTACCTGGTGGTGCCAGCGGGTGGTGGCGGCACCTTCCTGGGC
GGCTTCTTTGTGAACAAGCTCAGGCTCCGGGGCTCCGCGGTCATCAAGTTCTGCCTGTTC
TGCACCGTTGTCAGCCTGCTGGGCATCCTCGTCTTCTCACTGCACTGCCCCAGTGTGCCC
ATGGCGGGCGTCACAGCCAGCTACGGCGGGAGCCTCCTGCCCGAAGGCCACCTGAACCTA
ACGGCTCCCTGCAACGCTGCCTGCAGCTGCCAGCCAGAACACTACAGCCCTGTGTGCGGC
TCGGACGGCCTCATGTACTTCTCACTGTGCCACGCAGGGTGCCCTGCAGCCACGGAGACG
AATGTGGACGGCCAGAAGGTGTACCGAGACTGTAGCTGTATCCCTCAGAATCTTTCCTCT
GGTTTTGGCCATGCCACTGCAGGGAAATGCACTTCAACTTGTCAGAGAAAGCCCCTCCTT
CTGGTTTTCATATTCGTTGTAATTTTCTTTACATTCCTCAGCAGCATTCCTGCACTAACG
GCAACTCTACGATGTGTCCGTGACCCTCAGAGATCCTTTGCCCTGGGAATCCAGTGGATT
GTAGTTAGAATACTAGGGGGCATCCCGGGGCCCATCGCCTTCGGCTGGGTGATCGACAAG
GCCTGTCTGCTGTGGCAGGACCAGTGTGGCCAGCAGGGCTCCTGCTTGGTGTACCAGAAT
TCGGCCATGAGCCGCTACATACTCATCATGGGGCTCCTGTACAAGGTGCTGGGCGTCCTC
TTCTTTGCCATAGCCTGCTTCTTATACAAGCCCCTGTCGGAGTCTTCAGATGGCCTGGAA
ACTTGTCTGCCCAGCCAGTCCTCAGCCCCTGACAGTGCCACAGATAGCCAGCTCCAGAGC
AGCGTCTGA

# Macromolecular_Interacting_Partner_23_GenBank_ID_Gene:
AB031051

# Macromolecular_Interacting_Partner_23_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_23_Locus:
20q13.33

# Macromolecular_Interacting_Partner_23_SNPs:
rs34419428; rs1047099; rs6011477; rs34985812; rs3195701; rs3843758; rs6011369; rs6062690; rs3908923; rs7347500; rs2250931; rs6062689; rs2427363; rs4809464; rs1055196; rs2427365; rs6122080; rs6062723; rs2257367; rs2250853; rs6011438; rs3901528; rs11698303; rs2282313; rs2427364; rs17311216; rs2427362; rs12626098; rs6010766; rs2427367; rs2236553; rs872626; rs2282314; rs2258022; rs8125918; rs2427370; rs6062738; rs2275328; rs3787538; rs6011521; rs12481701; rs2275326; rs6011481; rs6062771; rs6011446; rs6011452; rs6010809; rs6090156; rs6011529; rs2427369; rs6062747; rs7263918; rs6011454; rs6011499; rs2427368; rs6011475; rs6011517; rs6122335; rs6011470; rs8124538; rs6010817; rs3787537; rs6090151; rs34190517; rs35183172; rs35517884; rs34474569; rs3761305; rs3848677; rs35070077; rs6062699; rs6062721; rs6090200; rs8116891; rs6122262; rs35989912; rs35552404; rs3842839; rs2427366; rs7270333; rs11274335; rs11696226; rs6122260; rs35415836; rs6010765; rs11475266; rs6090138; rs35768141; rs2427361; rs12233293; rs13433258; rs11699211; rs34200533; rs4264609; rs11476030; rs6512306; rs8184618; rs8119890; rs36035368; rs33947323; rs34171302; rs13041871; rs34570058; rs2275327; rs6062760; rs34247780; rs34464543; rs6011498; rs35150862; rs7270278; rs3838054; rs6011491; rs3060740; rs6011520; rs6010782; rs6011486; rs6090186; rs5842392; rs35059276; rs6090175; rs11421246; rs3827146; rs34701672; rs6090176; rs35667958; rs6011483; rs6062748; rs10624965; rs11475466; rs2277774; rs6062756; rs6011474; rs34471698; rs6090189; rs6011453; rs35977595; rs34442990; rs7263231; rs34340821; rs35747550; rs12626069; rs13037524; rs13037534; rs13040222; rs17318097; rs1815591; rs2185089; rs2313060; rs2313152; rs2427359; rs2427360; rs2427371; rs2427372; rs2427374; rs2427375; rs3915930; rs3915931; rs4239643; rs4549159; rs4606987; rs4809474; rs4809477; rs4809480; rs4809492; rs4809556; rs6010836; rs6010840; rs6011557; rs6011582; rs6011628; rs6011629; rs6011801; rs6062400; rs6062789; rs6062793; rs6062807; rs6062814; rs6062918; rs6089832; rs6089836; rs6089917; rs6090214; rs6122377; rs7261643; rs7266121; rs7267935; rs7271695; rs7273739; rs7274191; rs7508777; rs8123497; rs8124973

# Macromolecular_Interacting_Partner_23_General_References:
10873595; 11316767; 11780052

# Macromolecular_Interacting_Partner_23_References:
Not Available

End of HMDB00036

Beginning of HMDB00037
# Accession_No:
HMDB00037

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-25 16:14:23

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Aldosterone

# Description:
Aldosterone is a steroid hormone produced by the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood.  Specifically it regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.  It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It is the sole endogenous member of the class of mineralocorticoids. Aldosterone increases the permeability of the apical (luminal) membrane of the kidney's collecting ducts to potassium and sodium and activates their basolateral Na+/K+ pumps, stimulating ATP hydrolysis, reabsorbing sodium (Na+) ions and water into the blood, and excreting potassium (K+) ions into the urine.

# Synonyms:
(+)-Aldosterone; (11b)-11,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al; (11beta)-11,21-dihydroxy-3,20-dioxo-Pregn-4-en-18-al; 11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al; 11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-13-carbaldehyde; 11b,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al; 11beta,21-Dihydroxy-3,20-diketo-4-pregnen-18-al; 11beta,21-Dihydroxy-3,20-diketopregn-4-ene-18-al; 11beta,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al; 11beta,21-Dihydroxypregn-4-ene-3,18,20-trione; 18-Formyl-11beta,21-dihydroxy-4-pregnene-3,20-dione; 18-Oxocorticosterone; Aldocorten; Aldocortene; Aldocortin; Aldosteronum; Electrocortin; Elektrocortin; Reichstein X; aldosterone; d-Aldosterone; delta-Aldosterone

# Chemical_IUPAC_Name:
11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde

# Chemical_Formula:
C21H28O5

# Chemical_Structure:
tbl_chemical:::HMDB00037_ZOOM.png:::119283147449648866

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00037_THUMB.png:::119283147239863274

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Steroids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
aldehyde; ketone; primary alcohol; secondary alcohol; alkene

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
360.19370

# Molecular_Weight_Avg:
360.44403

# Smiles_String_isomeric:
C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4C[C@@H](C[C@]4(C[C@H](O)[C@H]23)C=O)C(=O)CO

# Smiles_String_canonical:
CC12CCC(=O)C=C1CCC3C4CC(CC4(CC(O)C23)C=O)C(=O)CO

# KEGG_Compound_ID:
C01780

# BioCyc_ID:
ALDOSTERONE

# PubChem_CID:
5839

# PubChem_SID:
841789; 4910; 8144488; 625873; 7978658; 3139122; 8153606; 115922; 7885975; 7853718; 148643

# OMIM_ID:
103900; 145260; 201910; 202010; 202355; 203400; 218030; 264350

# Metagene_ID:
CORTICOSTERONE METHYL OXIDASE I DEFICIENCY- CMO I: 486; CORTICOSTERONE METHYL OXIDASE II DEFICIENCY - CMO II: 487; 21-HYDROXYLASE DEFICIENCY (CYP21): 235

# BiGG_ID:
38397

# Wikipedia_ID:
Aldosterone

# METLIN_ID:
418

# Ref_ID:
15814845; 1769794; 8350592; 11686541; 10888242; 14551679; 16146128; 6748658; 11835920; 10440591; 3258645; 16420280; 15630041; 8328738; 15901525; 14694143; 16572107; 2118736; 14621191; 14608520

# ChEBI_ID:
27584

# CAS_Registry_Number:
52-39-1

# InChI:
InChI=1/C21H28O5/c1-20-5-4-14(24)7-13(20)2-3-15-16-6-12(18(26)10-22)8-21(16,11-23)9-17(25)19(15)20/h7,11-12,15-17,19,22,25H,2-6,8-10H2,1H3/t12-,15-,16-,17-,19+,20-,21-/m0/s1

# Synthesis_Reference:
Not Available

# Melting_Point:
166.5 oC

# Melting_Point_predicted:
137.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.0512 mg/mL at 37 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
0.116 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
1.08 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
1.38 [Predicted by ALOGPS]; 0.2 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00037.mol:::1180720963614653365

# SDF_File_[Text]:
tbl_chemical:::HMDB00037.sdf:::119283146543621858

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00037.pdb:::119283147072129608

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Aldosterone.gif:::1132732101265266164

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00037_peaks.txt:::1156309502881880473

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Aldosterone_C.gif:::1132737663886123329

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00037_peaks.txt:::115631069453339352

# Mass_Spectrum:
tbl_chemical:::HMDB00037.jpg:::1132798875609785928

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane; Cytoplasm; Extracellular; mitochondria

# Tissue_Location:
Adipose Tissue; Adrenal Cortex; Adrenal Gland; Adrenal Medulla; Cardiovascular System; Fibroblasts; Intestine; Kidney; Kidneys; Lung; Muscle; Nerves; Pancreas; Placenta; Platelet; Skeletal Muscle; Testes; Testis; Thyroid Gland

# deuterated:
No

# Biofluid_Location:
Blood; Saliva; Urine

# Concentration_[Normal]:
Urine	0.01 (0.006-0.014)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Tietz Clinical Guide to Laboratory Tests. Fourth Edition 2006 Alan H. B. Hu. Saunders/Elsevier
Blood	0.000026 (0.000008 - 0.000044)	uM	Adult:>18_yrs_old	Both	Normal	Tietz Clinical Guide to Laboratory Tests. Fourth Edition 2006 Alan H. B. Hu. Saunders/Elsevier
Blood	0.001 (0.000055 -  0.002)	uM	Adult:>18_yrs_old	Both	Normal	15901525
Saliva	<1.00	umol/L	Adult:>18_yrs_old	Both	Normal	6748658


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
21-hydroxylase Deficiency; Adenoma; Aldosteronism; Corticosterone Methyl Oxidase I Deficiency; Corticosterone Methyl Oxidase II Deficiency; Hypokalemia; Primary Aldosteronism

# Pathway_Names:
C21-Steroid hormone metabolism;Bile acid biosynthesis;Androgen and estrogen metabolism

# Pathway_Images:
;;

# KEGG_Images:
map00140;map00120;map00150

# Pathway_Graphs:
;;

# Pathway_SBMLs:
;;

# Metabolic_Enzyme_1_ID:
5808

# Metabolic_Enzyme_1_Name:
Cytochrome P450 11B2, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
CYPXIB2; P-450Aldo; Aldosterone synthase; ALDOS; Aldosterone-synthesizing enzyme; Steroid 18-hydroxylase; P-450C18

# Metabolic_Enzyme_1_Gene_Name:
CYP11B2

# Metabolic_Enzyme_1_Protein_Sequence:
>Cytochrome P450 11B2, mitochondrial precursor
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN

# Metabolic_Enzyme_1_Number_of_Residues:
503

# Metabolic_Enzyme_1_Molecular_Weight:
57561

# Metabolic_Enzyme_1_Theoretical_pI:
9.78

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_1_Specific_Function:
Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone

# Metabolic_Enzyme_1_Pathway:
map00140  C21-Steroid hormone metabolism;
GENES       HSA: 1584(CYP11B1) 1585(CYP11B2);
            MMU: 13072(Cyp11b2) 223628(LOC223628);
            RNO: 24293(Cyp11b1) 24294(Cyp11b2) 353498(Cyp11b3)

# Metabolic_Enzyme_1_Reaction:
corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.14.15.4;EC 1.14.15.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
181340

# Metabolic_Enzyme_1_SwissProt_ID:
C11B2_HUMAN (P19099)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
CYP11B2

# Metabolic_Enzyme_1_Geneatlas_id:
CYP11B2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2592

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_1_Gene_Sequence:
>1512 bp
ATGGCACTCAGGGCAAAGGCAGAGGTGTGCGTGGCAGCGCCCTGGCTGTGCCTGCAAAGG
GCACGGGCACTGGGCACTAGAGCCGCTCGGGCCCCTAGGACGGTGCTGCCGTTTGAAGCC
ATGCCCCAGCATCCAGGCAACAGGTGGCTGAGGCTGCTGCAGATGTGGAGGGAGCAGGGT
TATGAGCACCTGCACCTGGAGATGCACCAGACCTTCCAGGAGCTGGGGCCCATTTTCAGG
TACAACTTGGGAGGACCACGCATGGTGTGTGTGATGCTGCCGGAGGATGTGGAGAAGCTG
CAACAGGTGGACAGCCTGCATCCCTGCAGGATGATCCTGGAGCCCTGGGTGGCCATCAGA
CAACATCGTGGGCACAAATGTGGCGTGTTCTTGTTGAATGGGCCTGAATGGCGCTTCAAC
CGATTGCGGCTGAACCCAGATGTGCTGTCGCCCAAGGCCGTGCAGAGGTTCCTCCCGATG
GTGGATGCAGTGGCCAGGGACTTTTCCCAGGCCCTGAGGAAGAAGGTGCTGCAGAACGCC
CGGGGGAGCCTGACCCTGGACGTCCAGCCCAGCATCTTCCACTACACCATAGAAGCCAGC
AACTTAGCTCTTTTTGGAGAGCGGCTGGGCCTGGTTGGCCACAGCCCCAGTTCTGCCAGC
CTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCACCGTCCAGCTCATGTTCATG
CCCAGGAGCCTGTCTCGCTGGATCAGCCCCAAGGTGTGGAAGGAGCACTTTGAGGCCTGG
GACTGCATCTTCCAGTACGGTGACAACTGTATCCAGAAAATCTACCAGGAACTGGCCTTC
AACCGCCCTCAACACTACACAGGCATCGTGGCAGAGCTCCTGTTGAAGGCGGAACTGTCA
CTAGAAGCCATCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCGTGGACACGACAGCG
TTTCCGTTGCTGATGACGCTCTTTGAGCTGGCTCGGAACCCCGACGTGCAGCAGATCCTG
CGCAAGGAGAGCCTGGCCGCCGCAGCCAGCATCAGTGAACATCCCCAGAAGGCAACCACC
GAGCTGCCCTTGCTGCGGGCGGCCCTCAAGGAGACCTTGAGGCTCTACCCTGTGGGTCTG
TTTTTGGAGCGAGTGGTGAGCTCAGACTTGGTGCTTCAGAACTACCACATCCCAGCTGGG
ACATTGGTACAGGTTTTCCTCTACTCGCTGGGTCGCAATGCCGCCTTGTTCCCGAGGCCT
GAGCGGTATAATCCCCAGCGCTGGCTAGACATCAGGGGCTCCGGCAGGAACTTGCACCAC
GTGCCCTTTGGCTTTGGCATGCGCCAGTGCCTCGGGCGGCGCCTGGCAGAGGCAGAGATG
CTGCTGCTGCTGCACCACGTGCTGAAGCGCTTCCTGGTGGAGACACTAACTCAAGAGGAC
ATAAAGATGGTCTACAGCTTCATATTGAGGCCTGGCACGTCCCCCCTCCTCACTTTCAGA
GCGATTAACTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M32881

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_1_Locus:
8q21-q22

# Metabolic_Enzyme_1_SNPs:
rs4545; rs4544; rs6441; rs4537; rs4539; rs5312; rs6438; rs4536; rs4543; rs4538; rs5310; rs5313; rs5281; rs4546; rs3802230; rs3839864; rs3097; rs3802228; rs3201271; rs6431; rs6435; rs7461740; rs6397; rs6432; rs6429; rs11781816; rs6421; rs10107682; rs10090630; rs4072020; rs6399; rs10096239; rs6396; rs10099658; rs4736320; rs6433; rs7836572; rs13276226; rs5307; rs10099052; rs6418; rs6434; rs6416; rs10086846; rs12679242; rs6414; rs10110732; rs6415; rs11779229; rs6394; rs5306; rs6413; rs10090037; rs7463212; rs1799998; rs6471583; rs11781082; rs10087214; rs6992689; rs11991278; rs6440; rs12542987; rs5305; rs28931609; rs5315; rs5317; rs28930074; rs9297975; rs3201269; rs33921450; rs7463238; rs35574522; rs28390200; rs28491316; rs3201272; rs33936656; rs13257266; rs13268153; rs28531895; rs33911914; rs28361356; rs35733998; rs5895735; rs35490512; rs28526467; rs36018151; rs34144193; rs6436; rs28366703; rs13257680; rs1574565; rs5314; rs35909170; rs28394055; rs13263682; rs28615142; rs28497862; rs13252628; rs13257267; rs28659182; rs13268025; rs5895734; rs10956996; rs34951350; rs7463148; rs10623281; rs13254375; rs34884498; rs7464883; rs1800534; rs10096393; rs10108843; rs11775009; rs12546357; rs13267320; rs35431302; rs4379428; rs4736317; rs4736318; rs4736319; rs4736355; rs4736356; rs4736357; rs4736358; rs4736359; rs4736360; rs6471580; rs6471581; rs6471586; rs6651273; rs6981918; rs6987382; rs7004863; rs7011830; rs7011889; rs7011901; rs7016924; rs7460125; rs7819943; rs7820667; rs7821838; rs7824229; rs7828967; rs7831617; rs7844961; rs9643358

# Metabolic_Enzyme_1_General_References:
2592361; 2256920; 1594605; 1346492; 8439335; 9177280; 9625333; 9814506; 9931115; 10391209; 10391210; 11238478; 12788848

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5822

# Metabolic_Enzyme_2_Name:
3-oxo-5-beta-steroid 4-dehydrogenase

# Metabolic_Enzyme_2_Synonyms:
Delta(4-3- ketosteroid 5-beta-reductase; Aldo-keto reductase family 1 member D1

# Metabolic_Enzyme_2_Gene_Name:
AKR1D1

# Metabolic_Enzyme_2_Protein_Sequence:
>3oxo5betasteroid 4dehydrogenase
MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN
EHEVGEAIRE
KIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYII
EVPMAFKPGDEIYPRDENGKW
LYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLEL
ILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQ
QHDIVITAYSPLGTSRNPIWVNVSSPP
LLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERI
KENFQIFDFSLTEEEM
KDIEALNKNVRFVELLMWRDHPEYPFHDEY

# Metabolic_Enzyme_2_Number_of_Residues:
326

# Metabolic_Enzyme_2_Molecular_Weight:
37377

# Metabolic_Enzyme_2_Theoretical_pI:
7.58

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates

# Metabolic_Enzyme_2_Pathway:
map00140  C21-Steroid hormone metabolism

# Metabolic_Enzyme_2_Reaction:
4,5beta-dihydrocortisone + NADP+ = cortisone + NADPH + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.3.1.3

# Metabolic_Enzyme_2_GenBank_ID_Protein:
431857

# Metabolic_Enzyme_2_SwissProt_ID:
AK1D1_HUMAN (P51857)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
AKR1D1

# Metabolic_Enzyme_2_Geneatlas_id:
AKR1D1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:388

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>981 bp

ATGGATCTCAGTGCTGCAAGTCACCGCATACCTCTAAGTGATGGAAACAGCATTCCCAT
CATCGGACTTG
GTACCTACTCAGAACCTAAATCGACCCCTAAGGGAGCCTGTGCAACAT
CGGTGAAGGTTGCTATTGACAC
AGGGTACCGACATATTGATGGGGCCTACATCTACCAA
AATGAACACGAAGTTGGGGAGGCCATCAGGGAG
AAGATAGCAGAAGGAAAGGTGCGGAG
GGAAGATATCTTCTACTGTGGAAAGCTATGGGCTACAAATCATG
TCCCAGAGATGGTCC
GCCCAACCCTGGAGAGGACACTCAGGGTCCTCCAGCTAGATTATGTGGATCTTTA
CATC
ATTGAAGTACCCATGGCCTTTAAGCCAGGAGATGAAATATACCCTAGAGATGAGAATGGC
AAATGG
TTATATCACAAGTCAAATCTGTGTGCCACTTGGGAGGCGATGGAAGCTTGCAA
AGACGCTGGCTTGGTGA
AATCCCTGGGAGTGTCCAATTTTAACCGCAGGCAGCTGGAGC
TCATCCTGAACAAGCCAGGACTCAAACA
CAAGCCAGTCAGCAACCAGGTTGAGTGCCAT
CCGTATTTCACCCAGCCAAAACTCTTGAAATTTTGCCAA
CAACATGACATTGTCATTAC
TGCATATAGCCCTTTGGGGACCAGTAGGAATCCAATCTGGGTGAATGTTT
CTTCTCCAC
CTTTGTTAAAGGATGCACTTCTAAACTCATTGGGGAAAAGGTACAATAAGACAGCAGCTC
A
AATTGTTTTGCGTTTCAACATCCAGCGAGGGGTGGTTGTCATTCCTAAAAGCTTTAAT
CTTGAAAGGATC
AAAGAAAATTTTCAGATCTTTGACTTTTCTCTCACTGAAGAAGAAAT
GAAGGACATTGAAGCCTTGAATA
AAAATGTCCGCTTTGTAGAATTGCTCATGTGGCGCG
ATCATCCTGAATACCCATTTCATGATGAATACTG
A

# Metabolic_Enzyme_2_GenBank_ID_Gene:
Z28339

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_2_Locus:
7q32-q33

# Metabolic_Enzyme_2_SNPs:
rs34703687; rs1872929; rs7780066; rs3735023; rs1872930; rs11763625; rs7799169; rs17169523; rs12540339; rs12532715; rs7780438; rs11763063; rs17169522; rs2306847; rs3805361; rs2120846; rs6467736; rs2035648; rs11982192; rs6467734; rs7799130; rs10263205; rs10280818; rs2166188; rs10269530; rs10257928; rs3805360; rs7784881; rs7795946; rs6956827; rs10226024; rs10278929; rs4728430; rs10236161; rs10954603; rs12111721; rs10228704; rs8180809; rs10276854; rs6943498; rs17169518; rs12668157; rs6980334; rs2035736; rs10263802; rs17169521; rs10954602; rs2306845; rs3805362; rs10264658; rs9642091; rs6945659; rs7799647; rs3857868; rs7784424; rs6943935; rs6951769; rs12670660; rs17169511; rs12670239; rs7799469; rs2306846; rs17169513; rs7783021; rs10279265; rs10229533; rs7784068; rs1872928; rs7803336; rs17543126; rs7784561; rs7784275; rs10244249; rs7780347; rs1038626; rs6467735; rs6977075; rs10264216; rs10279757; rs7797080; rs10228366; rs10280628; rs11762514; rs2352140; rs2035647; rs7794061; rs10280600; rs17169512; rs7784563; rs7788077; rs2882947; rs6962195; rs3816829; rs10230440; rs7784075; rs10258807; rs10085803; rs10229164; rs10236488; rs4732288; rs10244250; rs3807332; rs10246884; rs7779865; rs10231078; rs11766258; rs2465921; rs12540340; rs2465920; rs35535735; rs10274304; rs13243518; rs28601801; rs35429213; rs4732290; rs10230015; rs192475; rs13239794; rs10271851; rs4141795; rs28533201; rs11378949; rs35063839; rs10276951; rs13243967; rs9642092; rs10230284; rs28853972; rs35402657; rs34205888; rs10276855; rs6975550; rs35473428; rs28698638; rs1186272; rs13228410; rs28378643; rs13243508; rs41274197; rs34060691; rs28479257; rs36119043; rs596658; rs13244061; rs13243992; rs13243602; rs10541658; rs10280394; rs7803480; rs10230507; rs35802315; rs2465083; rs13223644; rs9642093; rs41274194; rs35504713; rs34727188; rs28609414; rs34315519; rs3857869; rs34005857; rs5887865; rs35808917; rs13243764; rs1186273; rs10264483; rs10229138; rs7784629; rs34809975; rs10259579; rs35109728; rs34437071; rs28558091; rs34613519; rs35807033; rs35415283; rs13243510; rs7787591; rs3902226; rs28547527; rs34789634; rs28587485; rs10259580; rs11762575; rs11975510; rs4311613; rs11269285; rs35579520; rs35629548; rs34739493; rs35926233; rs10227099; rs10228772; rs10233399; rs10233624; rs10235317; rs10243853; rs10258577; rs1025967; rs10260689; rs10265064; rs10954601; rs11760991; rs11764114; rs11976842; rs1487999; rs1488000; rs1586497; rs1601823; rs17169507; rs17169524; rs17277937; rs1817686; rs1994462; rs2440798; rs2440799; rs2440801; rs2465911; rs2633359; rs2709984; rs2859828; rs34416298; rs3757393; rs4732285; rs6942538; rs6950501; rs6960318; rs7785557; rs7796011; rs7796171; rs7812287; rs9692029

# Metabolic_Enzyme_2_General_References:
7508385; 11342103

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5809

# Metabolic_Enzyme_3_Name:
Cytochrome P450 21

# Metabolic_Enzyme_3_Synonyms:
Cytochrome P450 XXI; Steroid 21- hydroxylase; 21-OHase; P450-C21; P-450c21; P450-C21B

# Metabolic_Enzyme_3_Gene_Name:
CYP21A2

# Metabolic_Enzyme_3_Protein_Sequence:
>Cytochrome P450 21
MLLLGLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYR
LHLGLQDVVV
LNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDLSLGDYSLLWKAH
KKLTRSALLLGIRDSMEPVVE
QLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFG
DKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVD
VIPFLRFFPNPGLRRLKQAIEKRDHIV
EMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGH
VHMAAVDLLIGGTETT
ANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIA
EVLRL
RPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKN
SRALA
FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQ
PFQVRLQPRGMGAHSP
GQNQ

# Metabolic_Enzyme_3_Number_of_Residues:
494

# Metabolic_Enzyme_3_Molecular_Weight:
55888

# Metabolic_Enzyme_3_Theoretical_pI:
7.90

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_3_Specific_Function:
Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids

# Metabolic_Enzyme_3_Pathway:
map00140  C21-Steroid hormone metabolism

# Metabolic_Enzyme_3_Reaction:
a steroid + AH2 + O2 = a 21-hydroxysteroid + A + H2O

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_3_Signals:
1-15

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.14.99.10

# Metabolic_Enzyme_3_GenBank_ID_Protein:
181290

# Metabolic_Enzyme_3_SwissProt_ID:
CP21A_HUMAN (P08686)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
CYP21A2

# Metabolic_Enzyme_3_Geneatlas_id:
CYP21A2

# Metabolic_Enzyme_3_hgnc_id:
HGNC:2600

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein

# Metabolic_Enzyme_3_Gene_Sequence:
>102 bp

CGCATGAGAGCCCAGCCCGGCACCCCTGTGGCCATTGAGGAGGAATTCTCTCTCCTCAC
CTGCAGCATCA
TCTGTTACCTCACCTTCGGAGACAAGATCAAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M19711

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_3_Locus:
6p21.3

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
3487786; 3486422; 3038528; 1406709; 3871526; 3497399; 1864962; 8081391; 3257825; 2303461; 1937474; 2072928; 1644925; 1406699; 1496017; 8478006; 7749410; 9067760; 9187661; 8989258; 9580109; 9497336; 10094562; 10408778; 10408786; 10051010; 10391209; 12788866; 12915679

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
6443

# Metabolic_Enzyme_4_Name:
Proto-oncogene tyrosine-protein kinase Src

# Metabolic_Enzyme_4_Synonyms:
p60-Src; c- Src; pp60c-src

# Metabolic_Enzyme_4_Gene_Name:
SRC

# Metabolic_Enzyme_4_Protein_Sequence:
>Protooncogene tyrosineprotein kinase Src
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL

# Metabolic_Enzyme_4_Number_of_Residues:
536

# Metabolic_Enzyme_4_Molecular_Weight:
59835

# Metabolic_Enzyme_4_Theoretical_pI:
7.47

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  protein-tyrosine kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

# Metabolic_Enzyme_4_Pathway:
Not Available

# Metabolic_Enzyme_4_Reaction:
Not Available

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF07714:Pkinase_Tyr;
PF00017:SH2;
PF00018:SH3_1

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.7.10.2

# Metabolic_Enzyme_4_GenBank_ID_Protein:
10635153

# Metabolic_Enzyme_4_SwissProt_ID:
SRC_HUMAN (P12931)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
SRC

# Metabolic_Enzyme_4_Geneatlas_id:
SRC

# Metabolic_Enzyme_4_hgnc_id:
HGNC:11283

# Metabolic_Enzyme_4_PDB_ID:
2SRC

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>1629 bp
ATGGGTAGCAACAAGAGCAAGCCCAAGGATGCCAGCCAGCGGCGCCGCAGCCTGGAGCCC
GCCGAGAACGTGCACGGCGCTGGCGGGGGCGCTTTCCCCGCCTCGCAGACCCCCAGCAAG
CCAGCCTCGGCCGACGGCCACCGCGGCCCCAGCGCGGCCTTCGCCCCCGCGGCCGCCGAG
CCCAAGCTGTTCGGAGGCTTCAACTCCTCGGACACCGTCACCTCCCCGCAGAGGGCGGGC
CCGCTGGCCGGTGGAGTGACCACCTTTGTGGCCCTCTATGACTATGAGTCTAGGACGGAG
ACAGACCTGTCCTTCAAGAAAGGCGAGCGGCTCCAGATTGTCAACAACACGAGGAAGGTG
GATGTCAGAGAGGGAGACTGGTGGCTGGCCCACTCGCTCAGCACAGGACAGACAGGCTAC
ATCCCCAGCAACTACGTGGCGCCCTCCGACTCCATCCAGGCTGAGGAGTGGTATTTTGGC
AAGATCACCAGACGGGAGTCAGAGCGGTTACTGCTCAATGCAGAGAACCCGAGAGGGACC
TTCCTCGTGCGAGAAAGTGAGACCACGAAAGGTGCCTACTGCCTCTCAGTGTCTGACTTC
GACAACGCCAAGGGCCTCAACGTGAAGCACTACAAGATCCGCAAGCTGGACAGCGGCGGC
TTCTACATCACCTCCCGCACCCAGTTCAACAGCCTGCAGCAGCTGGTGGCCTACTACTCC
AAACACGCCGATGGCCTGTGCCACCGCCTCACCACCGTGTGCCCCACGTCCAAGCCGCAG
ACTCAGGGCCTGGCCAAGGATGCCTGGGAGATCCCTCGGGAGTCGCTGCGGCTGGAGGTC
AAGCTGGGCCAGGGCTGCTTTGGCGAGGTGTGGATGGGGACCTGGAACGGTACCACCAGG
GTGGCCATCAAAACCCTGAAGCCTGGCACGATGTCTCCAGAGGCCTTCCTGCAGGAGGCC
CAGGTCATGAAGAAGCTGAGGCATGAGAAGCTGGTGCAGTTGTATGCTGTGGTTTCAGAG
GAGCCCATTTACATCGTCACGGAGTACATGAGCAAGGGGAGTTTGCTGGACTTTCTCAAG
GGGGAGACAGGCAAGTACCTGCGGCTGCCTCAGCTGGTGGACATGGCTGCTCAGATCGCC
TCAGGCATGGCGTACGTGGAGCGGATGAACTACGTCCACCGGGACCTTCGTGCAGCCAAC
ATCCTGGTGGGAGAGAACCTGGTGTGCAAAGTGGCGGACTTTGGGCTGGCTCGGCTCATT
GAAGACAATGAGTACACGGCGCGGCAAGGTGCCAAATTCCCCATCAAGTGGACGGCTCCA
GAAGCTGCCCTCTATGGCCGCTTCACCATCAAGTCGGACGTGTGGTCCTTCGGGATCCTG
CTGACTGAGCTCACCACAAAGGGACGGGTGCCCTACCCTGGGATGGTGAACCGCGAGGTG
CTGGACCAGGTGGAGCGGGGCTACCGGATGCCCTGCCCGCCGGAGTGTCCCGAGTCCCTG
CACGACCTCATGTGCCAGTGCTGGCGGAAGGAGCCTGAGGAGCGGCCCACCTTCGAGTAC
CTGCAGGCCTTCCTGGAGGACTACTTCACGTCCACCGAGCCCCAGTACCAGCCCGGGGAG
AACCTCTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AL133293

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_4_Locus:
20q12-q13

# Metabolic_Enzyme_4_SNPs:
rs1885257; rs744285; rs6018000; rs6018156; rs6017996; rs12329503; rs6094509; rs6018027; rs7275012; rs8126089; rs6018088; rs911496; rs6018148; rs6018199; rs6018042; rs1547836; rs6018038; rs747182; rs6018161; rs11905180; rs11697568; rs12106024; rs6090573; rs16986606; rs6017944; rs6094508; rs8117415; rs6063022; rs17785475; rs6018031; rs12480646; rs3762203; rs6012089; rs11905079; rs1547837; rs11908679; rs6063029; rs3940202; rs6090575; rs6094425; rs11907753; rs17787897; rs11906741; rs6012064; rs6066129; rs17194717; rs3762205; rs11697215; rs6090585; rs6018140; rs11904904; rs6018107; rs7269342; rs6017943; rs6018091; rs6011996; rs6018131; rs6018153; rs6017962; rs6018154; rs6017938; rs6018128; rs11908137; rs6090529; rs12479921; rs7347850; rs11908547; rs6090576; rs1573162; rs6018284; rs6018257; rs6018256; rs1570209; rs6124933; rs754625; rs11906658; rs8120573; rs6018246; rs6018233; rs2273677; rs3790149; rs10854173; rs754626; rs6018290; rs6012117; rs12233271; rs6090599; rs3790150; rs6124914; rs6017916; rs6017917; rs6017919; rs7273386; rs6011987; rs35093452; rs6018260; rs34881773; rs13036519; rs6018259; rs6018100; rs11483840; rs6094386; rs6122526; rs34905200; rs6018208; rs10535931; rs6018114; rs6066069; rs6090528; rs11468816; rs6018138; rs36003615; rs6018207; rs6094417; rs6090530; rs35008342; rs11470839; rs6124957; rs11472640; rs6018046; rs6124899; rs35931930; rs34256652; rs6122523; rs35987579; rs35694770; rs11470429; rs34071321; rs35475646; rs11470840; rs6090527; rs6090521; rs35624849; rs35282943; rs6011991; rs11479944; rs6090579; rs6094421; rs12106037; rs6017997; rs12481364; rs6066087; rs41282798; rs34939572; rs6018191; rs11450067; rs6090580; rs34795353; rs6094413; rs6090526; rs6018003; rs6094476; rs7352195; rs11086198; rs35472502; rs35466362; rs35522786; rs6066139; rs6090522; rs6066074; rs4810567; rs6017991; rs33975289; rs6124884; rs3762206; rs6018074; rs8125374; rs36113326; rs35074236; rs3762207; rs11472642; rs6090577; rs7348051; rs6066073; rs11473947; rs6094412; rs6018189; rs6066037; rs35623563; rs3078007; rs6094475; rs35528854; rs34660457; rs6066048; rs6018083; rs5841263; rs7345405; rs35422797; rs13036724; rs8117148; rs6017971; rs34916450; rs6012058; rs11697728; rs7264770; rs6066140; rs36208532; rs6017990; rs6066038; rs35784949; rs35731780; rs6094491; rs6066028; rs41282796; rs6094387; rs11467467; rs35547944; rs35732924; rs35446893; rs13043913; rs4809610; rs6063072; rs28763883; rs13039797; rs35489398; rs6124920; rs3827968; rs4810601; rs4809611; rs13043912; rs33973567; rs6124911; rs2295747; rs11475404; rs6018224; rs8115993; rs6018255; rs13038224; rs11479945; rs6122545; rs35311974; rs6066167; rs6066215; rs33926499; rs6018236; rs10714592; rs33965411; rs6018254; rs6094563; rs11467123; rs6018273; rs6124932; rs11086187; rs6094579; rs35223630; rs11474889; rs6066155; rs28763884; rs2145792; rs4810600; rs35480354; rs28763882; rs4810582; rs35182938; rs34190038; rs6063004; rs35683688; rs6094378; rs11427827; rs35612430; rs10084513; rs10084517; rs11697275; rs11905013; rs11908417; rs11908486; rs16986596; rs16986599; rs4809629; rs4810624; rs6011973; rs6017880; rs6017882; rs6017889; rs6017901; rs6017913; rs6018348; rs6018387; rs6018390; rs6018391; rs6094357; rs6094358; rs6094363; rs6094373; rs6094643; rs6122566; rs6124810; rs7272779; rs8114109; rs8117951; rs8118277; rs8118377

# Metabolic_Enzyme_4_General_References:
11780052; 3299057; 2582238; 2681803; 2581127; 12415108; 9024657; 9174343; 7532003

# Metabolic_Enzyme_4_References:
15699470; 16157790

# Metabolic_Enzyme_5_ID:
5683

# Metabolic_Enzyme_5_Name:
Cytochrome P450 11B1, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
CYPXIB1; P450C11; P-450c11; Steroid 11-beta-hydroxylase

# Metabolic_Enzyme_5_Gene_Name:
CYP11B1

# Metabolic_Enzyme_5_Protein_Sequence:
>Cytochrome P450 11B1, mitochondrial precursor
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPQRPGNRWLRLLQIWREQG
YEDLHLEVHQ
TFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAY
RQHRGHKCGVFLLNGPEWRFN
RLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQ
NARGSLTLDVQPSIFHYTIEASNLALFGERLG
LVGHSPSSASLNFLHALEVMFKSTVQL
MFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF
SRPQQYTSIVAELLLN
AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAAS
ISEHP
QKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVRVFLYSLGRNPA
LFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE
TLTQEDIKMVYSFILR
PSMCPLLTFRAIN

# Metabolic_Enzyme_5_Number_of_Residues:
503

# Metabolic_Enzyme_5_Molecular_Weight:
57530

# Metabolic_Enzyme_5_Theoretical_pI:
9.42

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_5_Specific_Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB

# Metabolic_Enzyme_5_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_5_Reaction:
a steroid + reduced adrenal ferredoxin + O2 = an 11beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_5_Signals:
1-23

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.14.15.4

# Metabolic_Enzyme_5_GenBank_ID_Protein:
181333

# Metabolic_Enzyme_5_SwissProt_ID:
C11B1_HUMAN (P15538)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
CYP11B1

# Metabolic_Enzyme_5_Geneatlas_id:
CYP11B1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:2591

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_5_Gene_Sequence:
>1512 bp

ATGGCACTCAGGGCAAAGGCAGAGGTGTGCATGGCAGTGCCCTGGCTGTCCCTGCAAAG
GGCACAGGCAC
TGGGCACGAGAGCCGCCCGGGTCCCCAGGACAGTGCTGCCCTTTGAAG
CCATGCCCCGGCGTCCAGGCAA
CAGGTGGCTGAGGCTGCTGCAGATCTGGAGGGAGCAG
GGTTATGAGGACCTGCACCTGGAAGTACACCAG
ACCTTCCAGGAACTGGGGCCCATTTT
CAGGTACGATTTGGGAGGAGCAGGCATGGTGTGTGTGATGCTGC
CGGAGGACGTGGAGA
AGCTGCAACAGGTGGACAGCCTGCATCCCCACAGGATGAGCCTGGAGCCCTGGGT
GGCC
TACAGACAACATCGTGGGCACAAATGTGGCGTGTTCTTGCTGAATGGGCCTGAATGGCGC
TTCAAC
CGATTGCGGCTGAATCCAGAAGTGCTGTCGCCCAACGCTGTGCAGAGGTTCCT
CCCGATGGTGGATGCAG
TGGCCAGGGACTTCTCCCAGGCCCTGAAGAAGAAGGTGCTGC
AGAACGCCCGGGGGAGCCTGACCCTGGA
CGTCCAGCCCAGCATCTTCCACTACACCATA
GAAGCCAGCAACTTGGCTCTTTTTGGAGAGCGGCTGGGC
CTGGTTGGCCACAGCCCCAG
TTCTGCCAGCCTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCA
CCGTCCAGC
TCATGTTCATGCCCAGGAGCCTGTCTCGCTGGACCAGCCCCAAGGTGTGGAAGGAGCACT
T
TGAGGCCTGGGACTGCATCTTCCAGTACGGCGACAACTGTATCCAGAAAATCTATCAG
GAACTGGCCTTC
AGCCGCCCTCAACAGTACACCAGCATCGTGGCGGAGCTCCTGTTGAA
TGCGGAACTGTCGCCAGATGCCA
TCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCG
TGGACACGACGGTGTTTCCCTTGCTGATGACGCT
CTTTGAGCTGGCTCGGAACCCCAAC
GTGCAGCAGGCCCTGCGCCAGGAGAGCCTGGCCGCCGCAGCCAGC
ATCAGTGAACATCC
CCAGAAGGCAACCACCGAGCTGCCCTTGCTGCGTGCGGCCCTCAAGGAGACCTTGC
GGC
TCTACCCTGTGGGTCTGTTTCTGGAGCGAGTGGCGAGCTCAGACTTGGTGCTTCAGAACT
ACCACAT
CCCAGCTGGGACATTGGTGCGCGTGTTCCTCTACTCTCTGGGTCGCAACCCC
GCCTTGTTCCCGAGGCCT
GAGCGCTATAACCCCCAGCGCTGGCTAGACATCAGGGGCTC
CGGCAGGAACTTCTACCACGTGCCCTTTG
GCTTTGGCATGCGCCAGTGCCTTGGGCGGC
GCCTGGCAGAGGCAGAGATGCTGCTGCTGCTGCACCATGT
GCTGAAACACCTCCAGGTG
GAGACACTAACCCAAGAGGACATAAAGATGGTCTACAGCTTCATATTGAGG
CCCAGCAT
GTGCCCCCTCCTCACCTTCAGAGCCATCAACTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M32879

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_5_Locus:
8q21

# Metabolic_Enzyme_5_SNPs:
rs4541; rs4534; rs5288; rs5294; rs6405; rs34620645; rs6410; rs5283; rs5290; rs6403; rs6419; rs34570566; rs5316; rs5284; rs5299; rs5301; rs7003319; rs5304; rs1134096; rs5303; rs1134095; rs5017238; rs5297; rs4736312; rs5300; rs3802229; rs6389; rs9657021; rs4310186; rs6388; rs7822986; rs6471570; rs6387; rs4535; rs4736315; rs10956991; rs5295; rs6393; rs7814006; rs7814020; rs7818826; rs4609179; rs7818953; rs11775687; rs6390; rs6398; rs10105643; rs6400; rs6392; rs12674916; rs7833415; rs6411; rs6391; rs12542799; rs6402; rs6395; rs6422; rs6409; rs5280; rs4736346; rs10093618; rs4736311; rs4471016; rs4313136; rs5292; rs28934586; rs5287; rs5282; rs4998901; rs5291; rs4998896; rs6407; rs4998898; rs4998902; rs4998900; rs4998899; rs4998903; rs4998897; rs9657022; rs5296; rs4998895; rs1137481; rs1137484; rs5302; rs35673190; rs5017237; rs1137480; rs1137485; rs12543598; rs5298; rs34274727; rs1137488; rs5017240; rs5027479; rs1137486; rs1137483; rs5027480; rs5017239; rs1137487; rs5027478; rs4998894; rs9657020; rs4999335; rs4236887; rs5286; rs13250178; rs4999334; rs35378570; rs28551743; rs36004897; rs5895733; rs34698173; rs12114482; rs28418310; rs10098023; rs4464947; rs4548164; rs4581033; rs4736308; rs4736309; rs4736310; rs4736349; rs4736350; rs6995180; rs7005638; rs7016088; rs7016594

# Metabolic_Enzyme_5_General_References:
2592361; 2401360; 7903314; 3499608; 1741400; 2022736; 9302260; 10599751; 10391209; 10391210

# Metabolic_Enzyme_5_References:
15703266; 16973756; 16984984

# Metabolic_Enzyme_6_ID:
6486

# Metabolic_Enzyme_6_Name:
Mitogen-activated protein kinase 1

# Metabolic_Enzyme_6_Synonyms:
Extracellular signal-regulated kinase 2; ERK-2; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; p42-MAPK; ERT1

# Metabolic_Enzyme_6_Gene_Name:
MAPK1

# Metabolic_Enzyme_6_Protein_Sequence:
>Mitogenactivated protein kinase 1
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS


# Metabolic_Enzyme_6_Number_of_Residues:
360

# Metabolic_Enzyme_6_Molecular_Weight:
41390

# Metabolic_Enzyme_6_Theoretical_pI:
6.99

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1

# Metabolic_Enzyme_6_Pathway:
Not Available

# Metabolic_Enzyme_6_Reaction:
Not Available

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00069:Pkinase

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.7.11.24

# Metabolic_Enzyme_6_GenBank_ID_Protein:
182191

# Metabolic_Enzyme_6_SwissProt_ID:
MK01_HUMAN (P28482)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
MAPK1

# Metabolic_Enzyme_6_Geneatlas_id:
MAPK1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:6871

# Metabolic_Enzyme_6_PDB_ID:
4ERK

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>1083 bp
ATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGAC
GTGGGGCCGCGCTACACCAACCTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGC
TCTGCTTATGATAATGTCAACAAAGTTCGAGTAGCTATCAAGAAAATCAGCCCCTTTGAG
CACCAGACCTACTGCCAGAGAACCCTGAGGGAGATAAAAATCTTACTGCGCTTCAGACAT
GAGAACATCATTGGAATCAATGACATTATTCGAGCACCAACCATCGAGCAAATGAAAGAT
GTATATATAGTACAGGACCTCATGGAAACAGATCTTTACAAGCTCTTGAAGACACAACAC
CTCAGCAATGACCATATCTGCTATTTTCTCTACCAGATCCTCAGAGGGTTAAAATATATC
CATTCAGCTAACGTTCTGCACCGTGACCTCAAGCCTTCCAACCTGCTGCTCAACACCACC
TGTGATCTCAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCAC
ACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTG
AATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAA
ATGCTTTCCAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAATCACATT
TTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCT
AGGAACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCA
AATGCTGACTCCAAAGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAG
AGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGT
GACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAG
GAAAAGCTAAAAGAACTAATTTTTGAAGAGACTGCTAGATTCCAGCCAGGATACAGATCT
TAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M84489

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_6_Locus:
22q11.2|22q11.21

# Metabolic_Enzyme_6_SNPs:
rs1803545; rs3729910; rs6928; rs13943; rs5755074; rs743411; rs3810610; rs17759598; rs2266965; rs2276008; rs2298432; rs1063311; rs9340; rs13515; rs2266966; rs7292198; rs8138018; rs17821423; rs13058; rs2298434; rs2283792; rs2266969; rs743409; rs6518986; rs5749998; rs5755694; rs6518951; rs1892847; rs2266967; rs2283793; rs5999521; rs5755745; rs8141851; rs4821402; rs5999752; rs6518997; rs3788332; rs5750113; rs11912710; rs9607287; rs2276010; rs2283791; rs5999515; rs9607298; rs1892848; rs11912377; rs2283795; rs9610470; rs7292302; rs8141815; rs9610355; rs2283796; rs4821263; rs9610375; rs11704205; rs4821401; rs17213172; rs5999614; rs8136867; rs4821371; rs7284924; rs2266968; rs1892846; rs4821367; rs5755579; rs2070505; rs8139215; rs5755099; rs5999842; rs9610338; rs3827303; rs5749939; rs2154944; rs17759796; rs7290469; rs7286558; rs2876981; rs8135916; rs2283794; rs5751273; rs6518968; rs2006893; rs5999749; rs5999550; rs8136902; rs11704117; rs3729914; rs4821336; rs5755654; rs11703350; rs11913721; rs17820162; rs8142455; rs12159146; rs7285387; rs9610374; rs7510592; rs9680623; rs5749984; rs9607285; rs8136405; rs11704433; rs11704847; rs9607274; rs2096687; rs17213286; rs5999704; rs11703678; rs9610496; rs9610500; rs11913453; rs7290932; rs11704597; rs13053945; rs5999750; rs11089745; rs4821337; rs2329881; rs5749937; rs1557288; rs4640486; rs5999452; rs5749986; rs9610371; rs10222287; rs3729912; rs9610315; rs4821339; rs11705173; rs4516540; rs8135386; rs9610458; rs9680622; rs2027656; rs9610417; rs13055356; rs7292924; rs9610400; rs12172554; rs9610324; rs12628258; rs17821572; rs9610487; rs8140233; rs5999823; rs1557287; rs17004026; rs9607272; rs17003502; rs11913063; rs8136590; rs17821500; rs9607286; rs2276005; rs9607340; rs3810609; rs2276006; rs9610271; rs3810608; rs1048748; rs35401654; rs1130164; rs3188781; rs41282607; rs34573886; rs3810611; rs12158121; rs35774216; rs35450537; rs1048752; rs35268998; rs2276007; rs34155605; rs34338438; rs35097784; rs11704800; rs9607264; rs7292584; rs34478799; rs1803546; rs12168996; rs35926036; rs35419717; rs34746140; rs3891788; rs5999532; rs5999787; rs11913120; rs7289300; rs28727550; rs9610323; rs34349809; rs34637918; rs5999793; rs12167814; rs11704381; rs35051857; rs11703242; rs8141026; rs11462556; rs5755664; rs11273917; rs13053225; rs11414253; rs5755376; rs35061420; rs33953967; rs35881327; rs2186545; rs36122515; rs5995102; rs11393133; rs28780784; rs10598132; rs28862404; rs28373639; rs10222258; rs12373966; rs5999653; rs12159151; rs11390969; rs34007644; rs35825500; rs13058633; rs13055533; rs13056289; rs11267198; rs34347426; rs34196957; rs9610446; rs35225688; rs28370372; rs7285926; rs3949122; rs9624360; rs12484706; rs28704920; rs13058223; rs4821369; rs5999460; rs2298433; rs9712854; rs11303516; rs35736049; rs5749967; rs9610341; rs12628210; rs5999822; rs34042646; rs35604132; rs8142827; rs35276275; rs35913408; rs34915608; rs11705262; rs35967578; rs35791287; rs34033501; rs7286970; rs11426902; rs34817343; rs13054553; rs28513891; rs5755240; rs35418579; rs34412833; rs9610317; rs9610504; rs9610414; rs9607330; rs5995052; rs9712903; rs2008611; rs35950684; rs9610286; rs4478016; rs34544205; rs9610481; rs35001275; rs5999799; rs5999484; rs13056532; rs13056790; rs11405543; rs12169154; rs12163200; rs33914475; rs4050958; rs35723944; rs36031460; rs35843533; rs8136165; rs28720995; rs34842862; rs35399662; rs8141500; rs34987537; rs13057484; rs34644063; rs36123701; rs5999869; rs13054793; rs28763889; rs11385908; rs5755141; rs34431893; rs13055420; rs34550586; rs7284903; rs35676446; rs34145288; rs3052710; rs10663958; rs5755389; rs28803281; rs7284305; rs9680639; rs5755151; rs5999502; rs9623462; rs5999785; rs3052739; rs5999791; rs12159799; rs9610294; rs9610454; rs5844472; rs13058418; rs3729913; rs9610367; rs7289846; rs10599826; rs35444904; rs35220860; rs13056791; rs2329882; rs8140010; rs33986273; rs36087626; rs9610314; rs13056005; rs34522282; rs12158504; rs33922907; rs35578418; rs10641589; rs13057392; rs12172215; rs9622287; rs11360402; rs11490038; rs9607313; rs35389108; rs8142650; rs35096158; rs4050957; rs5755611; rs8136204; rs12172360; rs5999792; rs28566555; rs35248177; rs9607283; rs9622201; rs36031695; rs35318935; rs34416472; rs10714076; rs5999525; rs35644012; rs11277747; rs3729909; rs11703624; rs12170038; rs5755237; rs11089747; rs34534734; rs9610328; rs35907379; rs35585950; rs9607329; rs3841771; rs9680638; rs28697123; rs9607320; rs11352870; rs9610459; rs10598131; rs9610386; rs9610368; rs35593415; rs33932545; rs11272759; rs13058216; rs10664466; rs9622385; rs9622169; rs5999877; rs5999880; rs36042810; rs9610505; rs9607343; rs35549484; rs11914029; rs12157534; rs12160084; rs12167593; rs12627782; rs17759568; rs2876980; rs3810606; rs5749806; rs5749811; rs5754968; rs5754971; rs5755040; rs5999335; rs5999891; rs8139376; rs9607241

# Metabolic_Enzyme_6_General_References:
1540184; 1319925; 12665801; 8794306

# Metabolic_Enzyme_6_References:
15975997; 16087789

# Metabolic_Enzyme_7_ID:
8123

# Metabolic_Enzyme_7_Name:
Renin precursor

# Metabolic_Enzyme_7_Synonyms:
Angiotensinogenase

# Metabolic_Enzyme_7_Gene_Name:
REN

# Metabolic_Enzyme_7_Protein_Sequence:
>Renin precursor
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR

# Metabolic_Enzyme_7_Number_of_Residues:
406

# Metabolic_Enzyme_7_Molecular_Weight:
45058

# Metabolic_Enzyme_7_Theoretical_pI:
7.07

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  pepsin A activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  aspartic-type endopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
Cleavage of Leu-|- bond in angiotensinogen to generate angiotensin I

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF07966:A1_Propeptide;
PF00026:Asp

# Metabolic_Enzyme_7_Signals:
1-23

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.4.23.15

# Metabolic_Enzyme_7_GenBank_ID_Protein:
190994

# Metabolic_Enzyme_7_SwissProt_ID:
RENI_HUMAN (P00797)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
REN

# Metabolic_Enzyme_7_Geneatlas_id:
REN

# Metabolic_Enzyme_7_hgnc_id:
HGNC:9958

# Metabolic_Enzyme_7_PDB_ID:
1BBS

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Secreted protein. Membrane. Note=Associated to membranes via binding to ATP6AP2

# Metabolic_Enzyme_7_Gene_Sequence:
>1221 bp
ATGGATGGATGGAGAAGGATGCCTCGCTGGGGACTGCTGCTGCTGCTCTGGGGCTCCTGT
ACCTTTGGTCTCCCGACAGACACCACCACCTTTAAACGGATCTTCCTCAAGAGAATGCCC
TCAATCCGAGAAAGCCTGAAGGAACGAGGTGTGGACATGGCCAGGCTTGGTCCCGAGTGG
AGCCAACCCATGAAGAGGCTGACACTTGGCAACACCACCTCCTCCGTGATCCTCACCAAC
TACATGGACACCCAGTACTATGGCGAGATTGGCATCGGCACCCCACCCCAGACCTTCAAA
GTCGTCTTTGACACTGGTTCGTCCAATGTTTGGGTGCCCTCCTCCAAGTGCAGCCGTCTC
TACACTGCCTGTGTGTATCACAAGCTCTTCGATGCTTCGGATTCCTCCAGCTACAAGCAC
AATGGAACAGAACTCACCCTCCGCTATTCAACAGGGACAGTCAGTGGCTTTCTCAGCCAG
GACATCATCACCGTGGGTGGAATCACGGTGACACAGATGTTTGGAGAGGTCACGGAGATG
CCCGCCTTACCCTTCATGCTGGCCGAGTTTGATGGGGTTGTGGGCATGGGCTTCATTGAA
CAGGCCATTGGCAGGGTCACCCCTATCTTCGACAACATCATCTCCCAAGGGGTGCTAAAA
GAGGACGTCTTCTCTTTCTACTACAACAGAGATTCCGAGAATTCCCAATCGCTGGGAGGA
CAGATTGTGCTGGGAGGCAGCGACCCCCAGCATTACGAAGGGAATTTCCACTATATCAAC
CTCATCAAGACTGGTGTCTGGCAGATTCAAATGAAGGGGGTGTCTGTGGGGTCATCCACC
TTGCTCTGTGAAGACGGCTGCCTGGCATTGGTAGACACCGGTGCATCCTACATCTCAGGT
TCTACCAGCTCCATAGAGAAGCTCATGGAGGCCTTGGGAGCCAAGAAGAGGCTGTTTGAT
TATGTCGTGAAGTGTAACGAGGGCCCTACACTCCCCGACATCTCTTTCCACCTGGGAGGC
AAAGAATACACGCTCACCAGCGCGGACTATGTATTTCAGGAATCCTACAGTAGTAAAAAG
CTGTGCACACTGGCCATCCACGCCATGGATATCCCGCCACCCACTGGACCCACCTGGGCC
CTGGGGGCCACCTTCATCCGAAAGTTCTACACAGAGTTTGATCGGCGTAACAACCGCATT
GGCTTCGCCTTGGCCCGCTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
L00073

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_7_Locus:
1q32

# Metabolic_Enzyme_7_SNPs:
rs11571117; rs11571098; rs11571083; rs5705; rs11571120; rs11571124; rs7521667; rs2887284; rs1464816; rs1917539; rs6693954; rs5706; rs11571123; rs10900555; rs6676670; rs10900557; rs11571079; rs11240688; rs11571108; rs10900556; rs2368564; rs11571104; rs11571102; rs5707; rs11571078; rs11571107; rs11571114; rs11571091; rs11571119; rs11571082; rs11571088; rs11571077; rs11571105; rs11240686; rs11571106; rs3215332; rs3795574; rs11571092; rs11571111; rs3795575; rs11571112; rs2177695; rs3730102; rs11240689; rs11571086; rs6665480; rs11571113; rs3730104; rs11571084; rs3730103; rs11571118; rs11571100; rs11240687; rs11571087; rs2272237; rs6674952; rs11571110; rs11571085; rs11571103; rs11571101; rs11571121; rs11240685; rs11571109; rs11571080; rs11571076; rs11578877; rs11571081; rs11571115; rs11571090; rs6676458; rs11571122; rs11571116; rs6681776; rs6668858; rs6682082; rs11571096; rs11571073; rs11571075; rs11571097; rs11571074; rs11571093; rs11571128; rs11571126; rs11571095; rs11571094; rs11571127; rs11571125; rs6704321; rs11542630; rs34069565; rs1126947; rs1042875; rs5704; rs1042874; rs11799601; rs3730101; rs28580264; rs13306600; rs11284490; rs28730746; rs13306601; rs28417178; rs4439406; rs34296392; rs3839003; rs35241727; rs5708; rs4396166; rs35201130; rs34481638; rs11571099; rs11581713; rs28730747; rs2177694; rs10494849; rs1106778; rs16853059; rs16853062; rs16853072; rs1917542; rs1997034; rs2293337; rs3795576; rs6688425; rs6702587; rs7539596; rs7548714; rs940651; rs940652

# Metabolic_Enzyme_7_General_References:
6324167; 3530608; 6391881; 6138751; 3032746; 2540188; 3516796; 2016271; 12045255; 2493678; 1608447

# Metabolic_Enzyme_7_References:
15351948; 15356010; 15361890; 15364336

# Macromolecular_Interacting_Partner_1_ID:
6554

# Macromolecular_Interacting_Partner_1_Name:
Serine/threonine-protein kinase Sgk1

# Macromolecular_Interacting_Partner_1_Synonyms:
Serum/glucocorticoid-regulated kinase 1

# Macromolecular_Interacting_Partner_1_Gene_Name:
SGK

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Serine/threonineprotein kinase Sgk1
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
FSYAPPTDSFL

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
431

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
48943

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
8.81

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, Kv1.3, or EAAT1

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00069:Pkinase;
PF00433:Pkinase_C

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 2.7.11.1

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
1834511

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
SGK1_HUMAN (O00141)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
SGK

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
SGK

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:10810

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cytoplasm. Nucleus. Endoplasmic reticulum. Note=Nuclear, upon phosphorylation

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1296 bp
ATGACGGTGAAAACTGAGGCTGCTAAGGGCACCCTCACTTACTCCAGGATGAGGGGCATG
GTGGCAATTCTCATCGCTTTCATGAAGCAGAGGAGGATGGGTCTGAACGACTTTATTCAG
AAGATTGCCAATAACTCCTATGCATGCAAACACCCTGAAGTTCAGTCCATCTTGAAGATC
TCCCAACCTCAGGAGCCTGAGCTTATGAATGCCAACCCTTCTCCTCCACCAAGTCCTTCT
CAGCAAATCAACCTTGGCCCGTCGTCCAATCCTCATGCTAAACCATCTGACTTTCACTTC
TTGAAAGTGATCGGAAAGGGCAGTTTTGGAAAGGTTCTTCTAGCAAGACACAAGGCAGAA
GAAGTGTTCTATGCAGTCAAAGTTTTACAGAAGAAAGCAATCCTGAAAAAGAAAGAGGAG
AAGCATATTATGTCGGAGCGGAATGTTCTGTTGAAGAATGTGAAGCACCCTTTCCTGGTG
GGCCTTCACTTCTCTTTCCAGACTGCTGACAAATTGTACTTTGTCCTAGACTACATTAAT
GGTGGAGAGTTGTTCTACCATCTCCAGAGGGAACGCTGCTTCCTGGAACCACGGGCTCGT
TTCTATGCTGCTGAAATAGCCAGTGCCTTGGGCTACCTGCATTCACTGAACATCGTTTAT
AGAGACTTAAAACCAGAGAATATTTTGCTAGATTCACAGGGACACATTGTCCTTACTGAT
TTCGGACTCTGCAAGGAGAACATTGAACACAACAGCACAACATCCACCTTCTGTGGCACG
CCGGAGTATCTCGCACCTGAGGTGCTTCATAAGCAGCCTTATGACAGGACTGTGGACTGG
TGGTGCCTGGGAGCTGTCTTGTATGAGATGCTGTATGGCCTGCCGCCTTTTTATAGCCGA
AACACAGCTGAAATGTACGACAACATTCTGAACAAGCCTCTCCAGCTGAAACCAAATATT
ACAAATTCCGCAAGACACCTCCTGGAGGGCCTCCTGCAGAAGGACAGGACAAAGCGGCTC
GGGGCCAAGGATGACTTCATGGAGATTAAGAGTCATGTCTTCTTCTCCTTAATTAACTGG
GATGATCTCATTAATAAGAAGATTACTCCCCCTTTTAACCCAAATGTGAGTGGGCCCAAC
GAGCTACGGCACTTTGACCCCGAGTTTACCGAAGAGCCTGTCCCCAACTCCATTGGCAAG
TCCCCTGACAGCGTCCTCGTCACAGCCAGCGTCAAGGAAGCTGCCGAGGCTTTCCTAGGC
TTTTCCTATGCGCCTCCCACGGACTCTTTCCTCTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
Y10032

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_1_Locus:
6q23

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
9114008; 9722955; 14574404; 10548550; 10191262; 10884438; 11154281; 12397388; 12631736

# Macromolecular_Interacting_Partner_1_References:
15452200; 15536167; 15576372; 16099816

# Macromolecular_Interacting_Partner_2_ID:
6752

# Macromolecular_Interacting_Partner_2_Name:
Epidermal growth factor receptor precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Receptor tyrosine-protein kinase ErbB-1

# Macromolecular_Interacting_Partner_2_Gene_Name:
EGFR

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Epidermal growth factor receptor precursor
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
1210

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
134279

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.67

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  epidermal growth factor receptor activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein-tyrosine kinase activity
Function:  transmembrane receptor protein tyrosine kinase activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  enzyme linked receptor protein signaling pathway
Process:  transmembrane receptor protein tyrosine kinase signaling pathway
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Isoform 2/truncated isoform may act as an antagonist

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00757:Furin-like;
PF07714:Pkinase_Tyr;
PF01030:Recep_L_domain

# Macromolecular_Interacting_Partner_2_Signals:
1-24

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
646-668

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
EC 2.7.10.1

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
757924

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
EGFR_HUMAN (P00533)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
EGFR

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
EGFR

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:3236

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cell membrane; single-pass type I membrane protein. Isoform 2:Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>3633 bp
ATGCGACCCTCCGGGACGGCCGGGGCAGCGCTCCTGGCGCTGCTGGCTGCGCTCTGCCCG
GCGAGTCGGGCTCTGGAGGAAAAGAAAGTTTGCCAAGGCACGAGTAACAAGCTCACGCAG
TTGGGCACTTTTGAAGATCATTTTCTCAGCCTCCAGAGGATGTTCAATAACTGTGAGGTG
GTCCTTGGGAATTTGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTAAAG
ACCATCCAGGAGGTGGCTGGTTATGTCCTCATTGCCCTCAACACAGTGGAGCGAATTCCT
TTGGAAAACCTGCAGATCATCAGAGGAAATATGTACTACGAAAATTCCTATGCCTTAGCA
GTCTTATCTAACTATGATGCAAATAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTA
CAGGAAATCCTGCATGGCGCCGTGCGGTTCAGCAACAACCCTGCCCTGTGCAACGTGGAG
AGCATCCAGTGGCGGGACATAGTCAGCAGTGACTTTCTCAGCAACATGTCGATGGACTTC
CAGAACCACCTGGGCAGCTGCCAAAAGTGTGATCCAAGCTGTCCCAATGGGAGCTGCTGG
GGTGCAGGAGAGGAGAACTGCCAGAAACTGACCAAAATCATCTGTGCCCAGCAGTGCTCC
GGGCGCTGCCGTGGCAAGTCCCCCAGTGACTGCTGCCACAACCAGTGTGCTGCAGGCTGC
ACAGGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACGAAGCCACGTGC
AAGGACACCTGCCCCCCACTCATGCTCTACAACCCCACCACGTACCAGATGGATGTGAAC
CCCGAGGGCAAATACAGCTTTGGTGCCACCTGCGTGAAGAAGTGTCCCCGTAATTATGTG
GTGACAGATCACGGCTCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGGAA
GACGGCGTCCGCAAGTGTAAGAAGTGCGAAGGGCCTTGCCGCAAAGTGTGTAACGGAATA
GGTATTGGTGAATTTAAAGACTCACTCTCCATAAATGCTACGAATATTAAACACTTCAAA
AACTGCACCTCCATCAGTGGCGATCTCCACATCCTGCCGGTGGCATTTAGGGGTGACTCC
TTCACACATACTCCTCCTCTGGATCCACAGGAACTGGATATTCTGAAAACCGTAAAGGAA
ATCACAGGGTTTTTGCTGATTCAGGCTTGGCCTGAAAACAGGACGGACCTCCATGCCTTT
GAGAACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCAGTTTTCTCTTGCAGTC
GTCAGCCTGAACATAACATCCTTGGGATTACGCTCCCTCAAGGAGATAAGTGATGGAGAT
GTGATAATTTCAGGAAACAAAAATTTGTGCTATGCAAATACAATAAACTGGAAAAAACTG
TTTGGGACCTCCGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCAAG
GCCACAGGCCAGGTCTGCCATGCCTTGTGCTCCCCCGAGGGCTGCTGGGGCCCGGAGCCC
AGGGACTGCGTCTCTTGCCGGAATGTCAGCCGAGGCAGGGAATGCGTGGACAAGTGCAAG
CTTCTGGAGGGTGAGCCAAGGGAGTTTGTGGAGAACTCTGAGTGCATACAGTGCCACCCA
GAGTGCCTGCCTCAGGCCATGAACATCACCTGCACAGGACGGGGACCAGACAACTGTATC
CAGTGTGCCCACTACATTGACGGCCCCCACTGCGTCAAGACCTGCCCGGCAGGAGTCATG
GGAGAAAACAACACCCTGGTCTGGAAGTACGCAGACGCCGGCCATGTGTGCCACCTGTGC
CATCCAAACTGCACCTACGGATGCACTGGGCCAGGTCTTGAAGGCTGTCCAACGAATGGG
CCTAAGATCCCGTCCATCGCCACTGGGATGGTGGGGGCCCTCCTCTTGCTGCTGGTGGTG
GCCCTGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCACGCTGCGG
AGGCTGCTGCAGGAGAGGGAGCTTGTGGAGCCTCTTACACCCAGTGGAGAAGCTCCCAAC
CAAGCTCTCTTGAGGATCTTGAAGGAAACTGAATTCAAAAAGATCAAAGTGCTGGGCTCC
GGTGCGTTCGGCACGGTGTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAATT
CCCGTCGCTATCAAGGAATTAAGAGAAGCAACATCTCCGAAAGCCAACAAGGAAATCCTC
GATGAAGCCTACGTGATGGCCAGCGTGGACAACCCCCACGTGTGCCGCCTGCTGGGCATC
TGCCTCACCTCCACCGTGCAACTCATCACGCAGCTCATGCCCTTCGGCTGCCTCCTGGAC
TATGTCCGGGAACACAAAGACAATATTGGCTCCCAGTACCTGCTCAACTGGTGTGTGCAG
ATCGCAAAGGGCATGAACTACTTGGAGGACCGTCGCTTGGTGCACCGCGACCTGGCAGCC
AGGAACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGATTTTGGGCTGGCCAAA
CTGCTGGGTGCGGAAGAGAAAGAATACCATGCAGAAGGAGGCAAAGTGCCTATCAAGTGG
ATGGCATTGGAATCAATTTTACACAGAATCTATACCCACCAGAGTGATGTCTGGAGCTAC
GGGGTGACCGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCTGCC
AGCGAGATCTCCTCCATCCTGGAGAAAGGAGAACGCCTCCCTCAGCCACCCATATGTACC
ATCGATGTCTACATGATCATGGTCAAGTGCTGGATGATAGACGCAGATAGTCGCCCAAAG
TTCCGTGAGTTGATCATCGAATTCTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTGTC
ATTCAGGGGGATGAAAGAATGCATTTGCCAAGTCCTACAGACTCCAACTTCTACCGTGCC
CTGATGGATGAAGAAGACATGGACGACGTGGTGGATGCCGACGAGTACCTCATCCCACAG
CAGGGCTTCTTCAGCAGCCCCTCCACGTCACGGACTCCCCTCCTGAGCTCTCTGAGTGCA
ACCAGCAACAATTCCACCGTGGCTTGCATTGATAGAAATGGGCTGCAAAGCTGTCCCATC
AAGGAAGACAGCTTCTTGCAGCGATACAGCTCAGACCCCACAGGCGCCTTGACTGAGGAC
AGCATAGACGACACCTTCCTCCCAGTGCCTGAATACATAAACCAGTCCGTTCCCAAAAGG
CCCGCTGGCTCTGTGCAGAATCCTGTCTATCACAATCAGCCTCTGAACCCCGCGCCCAGC
AGAGACCCACACTACCAGGACCCCCACAGCACTGCAGTGGGCAACCCCGAGTATCTCAAC
ACTGTCCAGCCCACCTGTGTCAACAGCACATTCGACAGCCCTGCCCACTGGGCCCAGAAA
GGCAGCCACCAAATTAGCCTGGACAACCCTGACTACCAGCAGGACTTCTTTCCCAAGGAA
GCCAAGCCAAATGGCATCTTTAAGGGCTCCACAGCTGAAAATGCAGAATACCTAAGGGTC
GCGCCACAAAGCAGTGAATTTATTGGAGCATGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
X00588

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_2_Locus:
7p12

# Macromolecular_Interacting_Partner_2_SNPs:
rs10258568; rs11543848; rs2072454; rs2293347; rs17290103; rs10258429; rs17290169; rs1050171; rs1140475; rs17290005; rs17290559; rs17337023; rs2302536; rs17289686; rs17336437; rs17336800; rs17289893; rs17336988; rs17290162; rs10228436; rs884225; rs10277413; rs712829; rs712830; rs17290225; rs17336995; rs759170; rs980653; rs712831; rs845554; rs759162; rs845561; rs2075112; rs1024748; rs1015793; rs2075110; rs984654; rs2075109; rs845552; rs2877260; rs6593206; rs1404908; rs12532468; rs917880; rs12718945; rs4947491; rs7803660; rs3735064; rs4947979; rs2058502; rs2075107; rs917879; rs887824; rs12668421; rs7798065; rs1344307; rs2330951; rs730437; rs6944695; rs11977660; rs6970029; rs12718946; rs2075101; rs11766798; rs11771471; rs7807517; rs2740763; rs4140770; rs6950826; rs6964647; rs4947963; rs10241326; rs1554718; rs12538371; rs3735059; rs723527; rs6947531; rs7795728; rs2017000; rs6970262; rs887826; rs2302534; rs6964705; rs2740764; rs1861005; rs6593207; rs12673622; rs763317; rs845559; rs11238349; rs11979158; rs845558; rs2241055; rs6593205; rs759169; rs11977388; rs7789965; rs11984267; rs1013127; rs7781264; rs7795743; rs759160; rs1861003; rs4947975; rs11506105; rs741153; rs6947594; rs11238354; rs3823585; rs2293348; rs2740762; rs6957176; rs917881; rs2270247; rs845560; rs11974185; rs10250225; rs12666347; rs10234806; rs7785163; rs6968014; rs2110290; rs2302535; rs11487218; rs2072453; rs9642564; rs12671550; rs1468727; rs7804688; rs7808697; rs1558544; rs13247687; rs759165; rs4947488; rs10244108; rs3800827; rs9642391; rs9692301; rs2075111; rs17172438; rs11770506; rs1558542; rs17337212; rs12669701; rs17335884; rs759166; rs11977757; rs17337353; rs12535536; rs17290336; rs10488141; rs2241054; rs12666182; rs17337289; rs4947983; rs17172431; rs7798980; rs7782830; rs10245472; rs17337331; rs7795564; rs11760406; rs17172450; rs11238353; rs17172455; rs17337233; rs6978771; rs11514996; rs17172446; rs1024750; rs747322; rs11770689; rs7786831; rs7780270; rs845555; rs11278449; rs17336184; rs10280515; rs17172434; rs17335808; rs10251909; rs7796139; rs1815156; rs6969570; rs17336331; rs17289099; rs2041647; rs17172443; rs1468726; rs2075103; rs17172448; rs11979406; rs13244618; rs7781062; rs10488140; rs13224708; rs2692451; rs4947978; rs17336744; rs7803520; rs6960438; rs11978110; rs17289638; rs17335898; rs17586344; rs6593210; rs17337135; rs6954351; rs17336101; rs17289001; rs11981175; rs4947987; rs12538489; rs3778866; rs4947986; rs13234622; rs2006704; rs17289434; rs2472520; rs6952904; rs741152; rs7785141; rs11979255; rs10241451; rs17172452; rs7799627; rs3735062; rs11536635; rs11976696; rs17290110; rs17172445; rs11973394; rs17172428; rs17336919; rs4947971; rs6956366; rs17337107; rs7801956; rs10488142; rs13243364; rs2075106; rs13437685; rs11977299; rs7785013; rs9649769; rs17337360; rs17172432; rs10447908; rs4947984; rs17336709; rs12672027; rs759158; rs11770531; rs17290253; rs17335738; rs17335864; rs7786946; rs17335759; rs6973500; rs4947973; rs7796872; rs17336451; rs1558543; rs17336974; rs6954181; rs17337051; rs17335891; rs17289413; rs4947490; rs2110285; rs17289078; rs10488137; rs12536476; rs17290587; rs12531163; rs12667668; rs17336386; rs17336282; rs10488143; rs747323; rs12535578; rs17336087; rs17172449; rs845556; rs3752651; rs17172430; rs17289672; rs845551; rs17335780; rs13222549; rs759167; rs4947492; rs17172451; rs17290406; rs12668175; rs4947972; rs4947985; rs741151; rs6959438; rs7785313; rs11981529; rs2075102; rs6975226; rs11978754; rs17290580; rs3735063; rs10269512; rs11772801; rs7781774; rs887825; rs11971773; rs17290678; rs17290692; rs1076452; rs12056121; rs12533495; rs17290426; rs12718939; rs11760524; rs1024749; rs6944906; rs17289984; rs17336149; rs11976065; rs11773818; rs10244987; rs4947974; rs3735061; rs17586365; rs17290378; rs11534100; rs17289582; rs12669749; rs11971051; rs7806790; rs10266005; rs12538116; rs10241363; rs17518446; rs13244925; rs7801281; rs729969; rs11974707; rs17337338; rs2041645; rs759159; rs1815157; rs7806891; rs17289725; rs17290489; rs17290033; rs11980828; rs17336493; rs17289274; rs7779645; rs17337121; rs17290301; rs17289907; rs11238352; rs1861002; rs10251695; rs2740761; rs10259974; rs17290183; rs17289533; rs10242263; rs10244468; rs6979102; rs17336352; rs17336577; rs6953397; rs11979536; rs17172436; rs6957999; rs17336310; rs17290552; rs845550; rs17290385; rs845557; rs17336556; rs17290734; rs17289148; rs6964933; rs17290727; rs17290545; rs17337444; rs6957411; rs12673110; rs17289977; rs17337247; rs17172441; rs17172426; rs759168; rs17336849; rs17336059; rs17336233; rs17335982; rs10256152; rs2692456; rs17336688; rs10276261; rs17290155; rs17335919; rs17290197; rs6965663; rs11971253; rs17290713; rs17289760; rs4947976; rs17335912; rs4947982; rs1861004; rs12112020; rs17289700; rs17337465; rs17336017; rs17289343; rs6593202; rs17336598; rs2041646; rs17289134; rs17514740; rs2877261; rs7782501; rs17288994; rs17335878; rs17336765; rs17337346; rs10244020; rs17290274; rs6593209; rs7809394; rs10258683; rs17290524; rs17335773; rs17289197; rs17290629; rs17336542; rs17336912; rs17290117; rs17335850; rs6959843; rs17289596; rs11980564; rs17289781; rs11521100; rs10229932; rs17290399; rs17336940; rs17335905; rs12535226; rs11238350; rs17289693; rs17335940; rs17289015; rs17290706; rs17337521; rs723526; rs1861007; rs17336423; rs17290720; rs6972381; rs17336779; rs17289970; rs2075108; rs17290461; rs7793720; rs17172437; rs17337191; rs17336653; rs17337303; rs17336933; rs17336660; rs17290671; rs17336821; rs17289141; rs4947967; rs11772679; rs17289802; rs17289809; rs17290392; rs17290748; rs17151934; rs4947966; rs17336500; rs11764242; rs10225877; rs17290075; rs17289561; rs9642565; rs737540; rs17289665; rs17290054; rs10273541; rs17289505; rs940813; rs17151952; rs17337268; rs11975526; rs17336031; rs17172435; rs17289232; rs7792218; rs17289575; rs17172425; rs9642393; rs13222385; rs9649847; rs17289746; rs17335961; rs17289512; rs10247160; rs11238346; rs17289043; rs17337310; rs17336080; rs17290741; rs10242779; rs17289385; rs17289991; rs17290246; rs17289092; rs17337114; rs1468724; rs7796081; rs17290061; rs17516612; rs17336205; rs17337296; rs6955125; rs17337493; rs17336024; rs17336254; rs9656703; rs4947988; rs759163; rs17289795; rs17335724; rs4590392; rs17172440; rs4947977; rs17151957; rs17172427; rs17290329; rs17290260; rs17335766; rs2692452; rs845562; rs17337100; rs7785854; rs17335752; rs6972246; rs17336289; rs17290371; rs6593201; rs17290357; rs3735058; rs17336737; rs17288966; rs17335717; rs17289949; rs17289872; rs6965365; rs17335745; rs17290510; rs17336108; rs17290124; rs845553; rs2075104; rs7784002; rs17336926; rs17336814; rs17336136; rs2075105; rs6593208; rs17289371; rs17337065; rs17337486; rs10241364; rs7784148; rs17172429; rs17336870; rs17172433; rs17336751; rs10225911; rs6958497; rs17290176; rs17290468; rs17290308; rs7779644; rs11981148; rs17290650; rs7804404; rs10256573; rs6593197; rs884904; rs759171; rs17335689; rs17288917; rs6965469; rs17335696; rs17335710; rs17290699; rs28929495; rs17336639; rs35515689; rs17337451; rs34352568; rs17337079; rs1140476; rs28384375; rs35918369; rs41321844; rs28384376; rs17289589; rs41494749; rs41396448; rs41420046; rs17337016; rs1063486; rs41522547; rs17290239; rs41499845; rs34043207; rs17337549; rs35473039; rs17290762; rs17288945; rs17337535; rs17337528; rs3807362; rs954311; rs41454444; rs17337009; rs41347952; rs5884404; rs35700282; rs41486949; rs17290755; rs5884400; rs17290350; rs17336198; rs36231681; rs17336177; rs35583802; rs17290267; rs17337177; rs35451379; rs17289788; rs17337500; rs13227565; rs3063039; rs2330950; rs11769870; rs17337324; rs17337030; rs28634290; rs17336212; rs17290503; rs34834666; rs35370311; rs3735060; rs17336191; rs36003468; rs6952965; rs28374832; rs17336947; rs35327977; rs41445246; rs35129851; rs35548632; rs7787051; rs28533424; rs17336863; rs17290664; rs17337205; rs13230678; rs17289554; rs34396811; rs17336226; rs17336619; rs3832476; rs28384374; rs10668776; rs17336338; rs2286962; rs35091605; rs35324931; rs34869938; rs13226762; rs2041648; rs41445047; rs10560613; rs41318645; rs41320254; rs4947965; rs11278025; rs10255899; rs17336400; rs6979667; rs17337149; rs6150121; rs36217273; rs17337282; rs17336772; rs6959684; rs36113077; rs13245120; rs17289851; rs10660950; rs41499254; rs17289914; rs17289456; rs34572421; rs35226721; rs17336612; rs17290287; rs17336570; rs41494445; rs34086818; rs35171442; rs17289392; rs34997281; rs41413244; rs34074299; rs17336472; rs17336967; rs17585650; rs17337128; rs34576937; rs17289225; rs28811354; rs11379797; rs6967929; rs17290068; rs768149; rs36101265; rs17289183; rs17290685; rs17337086; rs17336793; rs41373948; rs41344244; rs41488147; rs41364648; rs6954838; rs34753194; rs36017894; rs34687671; rs17290211; rs17289753; rs17289399; rs13240461; rs17336359; rs35199203; rs35876689; rs13228158; rs17336003; rs10233078; rs17289644; rs17337388; rs36114151; rs41424746; rs17289113; rs17336716; rs3063035; rs17337044; rs34638247; rs17289127; rs2110288; rs34041671; rs17335815; rs17336156; rs34119598; rs28557040; rs36074076; rs12718938; rs35822325; rs13310186; rs17337037; rs17290315; rs17289260; rs17336219; rs5884398; rs41498449; rs17336514; rs10252081; rs7808726; rs35243230; rs17289610; rs34617505; rs11337454; rs41462945; rs10609272; rs17336261; rs35419699; rs36025525; rs17335871; rs718836; rs28421208; rs10240870; rs10081281; rs10618345; rs845549; rs35969369; rs34724121; rs35462899; rs34808391; rs34755969; rs34751800; rs41298767; rs17289169; rs17290482; rs17289295; rs35958465; rs17336115; rs17336891; rs10229098; rs2110286; rs34072530; rs11280908; rs12536919; rs41362846; rs12535614; rs35008934; rs17290040; rs13243914; rs17289617; rs41368044; rs34737166; rs4947969; rs41344849; rs17290475; rs17336591; rs17337458; rs7781757; rs17335947; rs17336416; rs35951148; rs41492046; rs34254662; rs11762067; rs6962134; rs10564333; rs17335933; rs10046549; rs10259122; rs17289085; rs17337479; rs10618989; rs41395746; rs35679531; rs41474451; rs28552843; rs34723095; rs845547; rs17289935; rs17289427; rs11772099; rs17290204; rs5884403; rs11276204; rs17289998; rs41407249; rs17290190; rs17290082; rs17335829; rs41387647; rs41323247; rs36086067; rs17289120; rs2692453; rs28737319; rs35778067; rs10243865; rs1558545; rs17289357; rs17337416; rs34848679; rs34696698; rs35261409; rs35001050; rs41366547; rs17336324; rs17290594; rs34648195; rs10578460; rs4319040; rs34693985; rs34610296; rs17336486; rs5884397; rs17289050; rs17290622; rs28653292; rs17289281; rs17336038; rs3063038; rs17289309; rs17336380; rs4473992; rs17337430; rs2877259; rs10235245; rs17336373; rs34687896; rs35396623; rs17336898; rs1024747; rs11372886; rs17336905; rs35392351; rs17172453; rs41323746; rs13237127; rs35578833; rs7787060; rs41384551; rs17289631; rs17289942; rs17289239; rs17335731; rs17290138; rs28701637; rs36085258; rs17290089; rs10246420; rs36095339; rs17289956; rs17336066; rs17335836; rs2692455; rs845545; rs6969716; rs17289057; rs28505666; rs6967251; rs17336521; rs2472521; rs7784637; rs17289519; rs34118553; rs17289441; rs34720965; rs34101842; rs28444301; rs41341644; rs5015842; rs28704705; rs35450636; rs10241299; rs17290657; rs28728327; rs34022714; rs41421952; rs7789210; rs7787752; rs17290413; rs17289540; rs17289008; rs13234541; rs34807987; rs35633111; rs36002426; rs17336045; rs13237230; rs10543062; rs10631266; rs11405125; rs41491049; rs10225425; rs28384377; rs34139344; rs6970776; rs17289865; rs6947832; rs12718937; rs41446045; rs17336303; rs34580350; rs11396214; rs34059225; rs6954028; rs34783780; rs17288952; rs35892349; rs28683088; rs11381210; rs17289963; rs17337156; rs10227366; rs17337367; rs17289162; rs41323052; rs34619963; rs10540696; rs17288980; rs6948336; rs12667451; rs17290608; rs17290601; rs17336122; rs10650953; rs17288959; rs36045540; rs17289406; rs17336702; rs17336094; rs845548; rs17289204; rs17514371; rs17336884; rs7457993; rs34195760; rs17337374; rs17335989; rs35372285; rs11381480; rs10255134; rs28665309; rs41471148; rs17289624; rs17290096; rs17336247; rs13227700; rs17336275; rs17290026; rs1468725; rs13237226; rs2692450; rs17290454; rs10281594; rs34828355; rs1024745; rs41514345; rs3862854; rs17290420; rs1861006; rs17336366; rs17336646; rs35998188; rs5884402; rs34636342; rs41498945; rs34372589; rs13231202; rs17289568; rs34058394; rs36089840; rs10612331; rs17289211; rs17335794; rs726399; rs34760563; rs6971740; rs4487709; rs17336835; rs28628250; rs2110289; rs17335787; rs41367446; rs41402045; rs35999644; rs35004531; rs41399844; rs17336626; rs34287931; rs35701076; rs12538513; rs34259065; rs11347888; rs17335801; rs17289823; rs5884399; rs17336584; rs7787739; rs17335857; rs36031881; rs17336681; rs845546; rs6979621; rs28535343; rs940805; rs35056953; rs35957527; rs34383437; rs34384206; rs34784599; rs28573307; rs10273937; rs7808366; rs17289739; rs17289477; rs17336877; rs3173671; rs13237124; rs17290573; rs10279672; rs17290538; rs10572386; rs28411673; rs11376505; rs2692454; rs36124211; rs17290322; rs2110287; rs17289830; rs17289879; rs17337514; rs41519650; rs41466248; rs17290531; rs17337219; rs17335843; rs7800174; rs28416308; rs17289658; rs3063036; rs34478523; rs34594044; rs34282985; rs7800086; rs17289651; rs17290615; rs34291121; rs34758031; rs17336393; rs35456043; rs17289218; rs10268378; rs35225821; rs28656910; rs34533759; rs35184439; rs2192293; rs17337058; rs41436451; rs17336674; rs17288910; rs41359546; rs17288924; rs17290771; rs41371445; rs41399446; rs13228815; rs35782780; rs41509446; rs17335682; rs10215371; rs10277070; rs1107616; rs1107617; rs1107618; rs11761161; rs11971997; rs11973011; rs11977625; rs11978031; rs13242110; rs1357973; rs17151964; rs2280653; rs2330949; rs2331013; rs3088198; rs3800826; rs4051; rs4291223; rs6593211; rs6947902; rs6953202; rs6969537; rs7334; rs7776830; rs7784481; rs7790434; rs7792797; rs7809028; rs884419; rs884420; rs940806; rs940807; rs940810; rs940811

# Macromolecular_Interacting_Partner_2_General_References:
6328312; 7654368; 8918811; 9103388; 11161793; 6326261; 6330563; 6093780; 3329716; 1988448; 2991899; 6324343; 3138233; 2985580; 9556602; 6325948; 3039909; 2790960; 2543678; 8962717; 10731668; 11116146

# Macromolecular_Interacting_Partner_2_References:
15947891; 16543718

# Macromolecular_Interacting_Partner_3_ID:
7191

# Macromolecular_Interacting_Partner_3_Name:
Vasopressin-neurophysin 2-copeptin precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
AVP-NPII[Contains: Arg-vasopressin; Neurophysin 2; Neurophysin-II; Copeptin]

# Macromolecular_Interacting_Partner_3_Gene_Name:
AVP

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Vasopressinneurophysin 2copeptin precursor
MPDTMLPACFLGLLAFSSACYFQNCPRGGKRAMSDLELRQCLPCGPGGKGRCFGPSICCA
DELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAAFGVCCNDESCVTEPECREGF
HRRARASDRSNATQLDGPAGALLLRLVQLAGAPEPFEPAQPDAY

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
164

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
17325

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
4.94

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
Function:  neuropeptide hormone activity
Function:  neurohypophyseal hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00220:Hormone_4;
PF00184:Hormone_5

# Macromolecular_Interacting_Partner_3_Signals:
1-19

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
340303

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
NEU2_HUMAN (P01185)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
AVP

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
AVP

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:894

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>495 bp
ATGCCTGACACCATGCTGCCCGCCTGCTTCCCTGGCCTACTGGCCTTCTCCTCCGCGTGC
TACTTCCAGAACTGCCCGAGGGGCGGCAAGAGGGCCATGTCCGACCTGGAGCTGAGACAG
TGCCTCCCCTGCGGCCCCGGGGGCAAAGGCCGCTGCTTCGGGCCCAGCATCTGCTGCGCG
GACGAGCTGGGCTGCTTCGTGGGCACGGCTGAGGCGCTGCGCTGCCAGGAGGAGAACTAC
CTGCCGTCGCCCTGCCAGTCCGGCCAGAAGGCGTGCGGGAGCGGGGGCCGCTGCGCCGCC
TTCGGCGTTTGCTGCAACGACGAGAGCTGCGTGACCGAGCCCGAGTGCCGCGAGGGCTTT
CACCGCCGCGCCCGCGCCAGCGACCGGAGCAACGCCACGCAGCTGGACGGGCCGGCCGGG
GCCTTGCTGCTGCGGCTGGTGCAGCTGGCCGGGGCGCCCGAGCCCTTCGAGCCCGCCCAG
CCCGACGCCTACTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
M11166

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_3_Locus:
20p13

# Macromolecular_Interacting_Partner_3_SNPs:
rs5195; rs2282018; rs3787482; rs2740204; rs2770381; rs2740185; rs6037481; rs3761249; rs3729965; rs6115785; rs1887854; rs11697831; rs1051744; rs28934878; rs13041277; rs13041150; rs13041148; rs3729964; rs1051747; rs13041122; rs1051748; rs1051746; rs6115784; rs2740190; rs11482923; rs13037218; rs4815565; rs34852810; rs7362057; rs2770380; rs1410713; rs2740188; rs2740207; rs2740208; rs2740210; rs2770378; rs4813627; rs6037478; rs6051572; rs6051578; rs6084265

# Macromolecular_Interacting_Partner_3_General_References:
2991279; 3768139; 4065330; 1740104; 11780052; 6574452; 7271787; 8370682; 8103767; 8514868; 8045958; 7714110; 8554046; 9360520; 9580132; 9814475; 10369876; 11017955; 11150885; 10677561; 11748489; 11161827; 11980620; 12012274; 12107248; 12359138; 12519420

# Macromolecular_Interacting_Partner_3_References:
15722667; 15951481

# Macromolecular_Interacting_Partner_4_ID:
7197

# Macromolecular_Interacting_Partner_4_Name:
Corticotropin-lipotropin precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
Pro-opiomelanocortin; POMC[Contains: NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin]

# Macromolecular_Interacting_Partner_4_Gene_Name:
POMC

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Corticotropinlipotropin precursor
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
267

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
29424

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Beta-endorphin and Met-enkephalin are endogenous opiates

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00976:ACTH_domain;
PF08384:NPP;
PF08035:Op_neuropeptide

# Macromolecular_Interacting_Partner_4_Signals:
1-26

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
190188

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
COLI_HUMAN (P01189)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
POMC

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
POMC

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:9201

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>789 bp
TGCAGCCGCTCGGGGGCCCTGTTGCTGGCCTTGCTGCTTCAGGCCTCCATGGAAGTGCGT
GGCTGGTGCCTGGAGAGCAGCCAGTGTCAGGACCTCACCACGGAAAGCAACCTGCTGGAG
TGCATCCGGGCCTGCAAGCCCGACCTCTCGGCCGAGACTCCCATGTTCCCGGGAAATGGC
GACGAGCAGCCTCTGACCGAGAACCCCCGGAAGTACGTCATGGGCCACTTCCGCTGGGAC
CGATTCGGCCGCCGCAACAGCAGCAGCAGCGGCAGCAGCGGCGCAGGGCAGAAGCGCGAG
GACGTCTCAGCGGGCGAAGACTGCGGCCCGCTGCCTGAGGGCGGCCCCGAGCCCCGCAGC
GATGGTGCCAAGCCGGGCCCGCGCGAGGGCAAGCGCTCCTACTCCATGGAGCACTTCCGC
TGGGGCAAGCCGGTGGGCAAGAAGCGGCGCCCAGTGAAGGTGTACCCTAACGGCGCCGAG
GACGAGTCGGCCGAGGCCTTCCCCCTGGAGTTCAAGAGGGAGCTGACTGGCCAGCGACTC
CGGGAGGGAGATGGCCCCGACGGCCCTGCCGATGACGGCGCAGGGGCCCAGGCCGACCTG
GAGCACAGCCTGCTGGTGGCGGCCGAGAAGAAGGACGAGGGCCCCTACAGGATGGAGCAC
TTCCGCTGGGGCAGCCCGCCCAAGGACAAGCGCTACGGCGGTTTCATGACCTCCGAGAAG
AGCCAGACGCCCCTGGTGACGCTGTTCAAAAACGCCATCATCAAGAACGCCTACAAGAAG
GGCGAGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
M38297

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_4_Locus:
2p23.3

# Macromolecular_Interacting_Partner_4_SNPs:
rs28932472; rs8192606; rs28932471; rs35254395; rs8192605; rs28930368; rs2071345; rs34650613; rs1042571; rs11679531; rs6713532; rs7565877; rs6713396; rs12473543; rs6756695; rs6545975; rs6756566; rs28932474; rs28932476; rs28932475; rs28932473; rs10654394; rs28932470; rs3039380; rs35411223; rs35023083; rs33950052; rs7591899; rs15461; rs2071344; rs13388660; rs9973478; rs11353932; rs13404336; rs7565427; rs34619618; rs8192607; rs35639116; rs34526166; rs10188864; rs10195561; rs11892647; rs12472851; rs13418937; rs17046887; rs17046891; rs1866146; rs2071343; rs2118404; rs2164808; rs3769671; rs3795955; rs3820935; rs6545976; rs6719226; rs6734859; rs7589318; rs7605927; rs934778

# Macromolecular_Interacting_Partner_4_General_References:
6274691; 6299668; 6314261; 3606677; 6254047; 6945581; 6267033; 6272808; 4352834; 4334191; 4338630; 4347148; 1264228; 195688; 2424570; 2839146; 7828531; 9768693; 10193875; 11244459

# Macromolecular_Interacting_Partner_4_References:
15351948; 15761539; 15764080; 15826924

# Macromolecular_Interacting_Partner_5_ID:
7549

# Macromolecular_Interacting_Partner_5_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
INS

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_5_Signals:
1-24

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
INS

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_5_Locus:
11p15.5

# Macromolecular_Interacting_Partner_5_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_5_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_5_References:
15671919; 16043663; 16139686; 16318400

# Macromolecular_Interacting_Partner_6_ID:
7551

# Macromolecular_Interacting_Partner_6_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_6_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_6_Locus:
6p21.3

# Macromolecular_Interacting_Partner_6_SNPs:
Not Available

# Macromolecular_Interacting_Partner_6_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_6_References:
15754848; 15853966; 16298263; 17142138

# Macromolecular_Interacting_Partner_7_ID:
7555

# Macromolecular_Interacting_Partner_7_Name:
Fibronectin precursor

# Macromolecular_Interacting_Partner_7_Synonyms:
FN; Cold-insoluble globulin; CIG

# Macromolecular_Interacting_Partner_7_Gene_Name:
FN1

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Fibronectin precursor
MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQ
INQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMI
WDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCK
PIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSY
RIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHP
QPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPC
VLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTQGGNSNGALC
HFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRI
GDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHM
LNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQ
PLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIP
GHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSP
LVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDL
LPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITG
YRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTG
TPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNT
FAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWTPP
RAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATG
VFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVV
SGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTVSWERSTT
PDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPIS
DTIIPAVPPPTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSD
NAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIA
PRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLL
IGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSK
STATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISV
KWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGE
SQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAP
DGEEDTAELQGLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTDLKFTQVTPTSLSA
QWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLT
SRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANGQTPIQRT
IKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDASTAIDAPSNLRFLATTPNSLL
VSWQPPRARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ
KSEPLIGRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFVTHPGYDTGNGIQLPGTS
GQQPSVGQQMIFEEHGFRRTTPPTTATPIRHRPRPYPPNVGEEIQIGHIPREDVDYHLYP
HGPGLNPNASTGQEALSQTTISWAPFQDTSEYIISCHPVGTDEEPLQFRVPGTSTSATLT
GLTRGATYNIIVEALKDQQRHKVREEVVTVGNSVNEGLNQPTDDSCFDPYTVSHYAVGDE
WERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQMMSCTCLG
NGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGGEP
SPEGTTGQSYNQYSQRYHQRTNTNVNCPIECFMPLDVQADREDSRE

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
2386

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
262609

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
5.42

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00039:fn1;
PF00040:fn2;
PF00041:fn3

# Macromolecular_Interacting_Partner_7_Signals:
1-31

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
12053817

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
FINC_HUMAN (P02751)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
FN1

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
FN1

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:3778

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Secreted protein; extracellular space; extracellular matrix

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1929 bp
ATGCTTAGGGGTCCGGGGCCCGGGCTGCTGCTGCTGGCCGTCCAGTGCCTGGGGACAGCG
GTGCCCTCCACGGGAGCCTCGAAGAGCAAGAGGCAGGCTCAGCAAATGGTTCAGCCCCAG
TCCCCGGTGGCTGTCAGTCAAAGCAAGCCCGGTTGTTATGACAATGGAAAACACTATCAG
ATAAATCAACAGTGGGAGCGGACCTACCTAGGCAATGCGTTGGTTTGTACTTGTTATGGA
GGAAGCCGAGGTTTTAACTGCGAGAGTAAACCTGAAGCTGAAGAGACTTGCTTTGACAAG
TACACTGGGAACACTTACCGAGTGGGTGACACTTATGAGCGTCCTAAAGACTCCATGATC
TGGGACTGTACCTGCATCGGGGCTGGGCGAGGGAGAATAAGCTGTACCATCGCAAACCGC
TGCCATGAAGGGGGTCAGTCCTACAAGATTGGTGACACCTGGAGGAGACCACATGAGACT
GGTGGTTACATGTTAGAGTGTGTGTGTCTTGGTAATGGAAAAGGAGAATGGACCTGCAAG
CCCATAGCTGAGAAGTGTTTTGATCATGCTGCTGGGACTTCCTATGTGGTCGGAGAAACG
TGGGAGAAGCCCTACCAAGGCTGGATGATGGTAGATTGTACTTGCCTGGGAGAAGGCAGC
GGACGCATCACTTGCACTTCTAGAAATAGATGCAACGATCAGGACACAAGGACATCCTAT
AGAATTGGAGACACCTGGAGCAAGAAGGATAATCGAGGAAACCTGCTCCAGTGCATCTGC
ACAGGCAACGGCCGAGGAGAGTGGAAGTGTGAGAGGCACACCTCTGTGCAGACCACATCG
AGCGGATCTGGCCCCTTCACCGATGTTCGTGCAGCTGTTTACCAACCGCAGCCTCACCCC
CAGCCTCCTCCCTATGGCCACTGTGTCACAGACAGTGGTGTGGTCTACTCTGTGGGGATG
CAGTGGCTGAAGACACAAGGAAATAAGCAAATGCTTTGCACGTGCCTGGGCAACGGAGTC
AGCTGCCAAGAGACAGCTGTAACCCAGACTTACGGTGGCAACTCAAATGGAGAGCCATGT
GTCTTACCATTCACCTACAACGACAGGACGGACAGCACAACTTCGAATTATGAGCAGGAC
CAGAAATACTCTTTCTGCACAGACCACACTGTTTTGGTTCAGACTCGAGGAGGAAATTCC
AATGGTGCCTTGTGCCACTTCCCCTTCCTATACAACAACCACAATTACACTGATTGCACT
TCTGAGGGCAGAAGAGACAACATGAAGTGGTGTGGGACCACACAGAACTATGATGCCGAC
CAGAAGTTTGGGTTCTGCCCCATGGCTGCCCACGAGGAAATCTGCACAACCAATGAAGGG
GTCATGTACCGCATTGGAGATCAGTGGGATAAGCAGCATGACATGGGTCACATGATGAGG
TGCACGTGTGTTGGGAATGGTCGTGGGGAATGGACATGCATTGCCTACTCGCAGCTTCGA
GATCAGTGCATTGTTGATGACATCACTTACAATGTGAACGACACATTCCACAAGCGTCAT
GAAGAGGGGCACATGCTGAACTGTACATGCTTCGGTCAGGGTCGGGGCAGGTGGAAGTGT
GATCCCGTCGACCAATGCCAGGATTCAGAGACTGGGACGTTTTATCAAATTGGAGATTCA
TGGGAGAAGTATGTGCATGGTGTCAGATACCAGTGCTACTGCTATGGCCGTGGCATTGGG
GAGTGGCATTGCCAACCTTTACAGACCTATCCAAGCTCAAGTGGTCCTGTCGAAGTATTT
ATCACTGAGACTCCGAGTCAGCCCAACTCCCACCCCATCCAGTGGAATGCACCACAGCCA
TCTCACATTTCCAAGTACATTCTCAGGTGGAGACCTGTGAGTATCCCACCCAGAAACCTT
GGATACTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
AJ276395

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_7_Locus:
2q34

# Macromolecular_Interacting_Partner_7_SNPs:
rs6728999; rs17449032; rs1250259; rs1053238; rs7584505; rs13652; rs7596677; rs2289202; rs7589580; rs11651; rs34923683; rs1263; rs1264; rs1250215; rs1250270; rs2289199; rs1250249; rs2692228; rs1250250; rs1250238; rs724617; rs2888354; rs1250248; rs1250240; rs940739; rs1250239; rs1250241; rs1561301; rs1250210; rs1250269; rs7575234; rs1250268; rs7586990; rs10202483; rs10804242; rs7557114; rs7570208; rs1250203; rs1437799; rs2577290; rs7609476; rs6707530; rs10199059; rs1250242; rs2577297; rs1525351; rs7560662; rs6725958; rs2692230; rs7588661; rs1347694; rs7349218; rs2577302; rs1968510; rs12615520; rs10932613; rs6435906; rs1561302; rs13021377; rs6435903; rs7574485; rs6731557; rs1866155; rs1437798; rs1250204; rs6744921; rs7588830; rs10207245; rs7608342; rs2304573; rs7567647; rs4622720; rs6734955; rs1837121; rs2462591; rs13423742; rs3213885; rs13018173; rs13306359; rs2692234; rs10498037; rs7568287; rs1250247; rs1250245; rs940740; rs13432972; rs1975319; rs17517509; rs9288508; rs7560554; rs1250213; rs12466925; rs1898536; rs2577289; rs1437797; rs2289200; rs7594168; rs17457002; rs10172425; rs1250244; rs1437795; rs3796123; rs6709607; rs13004592; rs12105173; rs11693652; rs7575551; rs6435905; rs10498038; rs17457252; rs2372544; rs10201850; rs1250214; rs9288507; rs1250246; rs940738; rs11883812; rs7598634; rs17516906; rs2289198; rs13431081; rs1250258; rs1250201; rs17456939; rs2372545; rs4328631; rs1250243; rs1437796; rs13020766; rs2692224; rs13414859; rs1370561; rs12694363; rs2577298; rs10185587; rs17457029; rs1525352; rs1250211; rs17457391; rs11687442; rs12468524; rs17456054; rs3732355; rs2372542; rs17458018; rs16854055; rs10179882; rs6435904; rs16854041; rs13306373; rs13306365; rs7422428; rs10804241; rs11674123; rs3214671; rs2692223; rs13416478; rs16853839; rs7572169; rs1250212; rs7579867; rs13385786; rs2692227; rs1250256; rs10188325; rs7562453; rs13021679; rs1968509; rs6728950; rs7580800; rs12991003; rs11897708; rs12472383; rs6716361; rs1250264; rs17517928; rs34255697; rs7592898; rs33996776; rs1250267; rs6729052; rs17515300; rs7595740; rs7598545; rs12464459; rs2692222; rs11690611; rs16853986; rs7580569; rs13306364; rs11687611; rs1058361; rs1250209; rs13306372; rs34043251; rs2577301; rs28379061; rs11544109; rs2118413; rs11544105; rs34174607; rs11544106; rs6782; rs35223740; rs35151953; rs35525385; rs2692226; rs35343655; rs13394662; rs34228975; rs10605109; rs10170514; rs34300660; rs13008516; rs35292159; rs28464508; rs35819982; rs34685276; rs35762962; rs17514904; rs35800609; rs1063272; rs2028203; rs1250205; rs11367419; rs5838505; rs35913187; rs34978418; rs1250207; rs7556711; rs2438174; rs36086086; rs7422768; rs10203450; rs7598615; rs10599440; rs35126158; rs5838506; rs5838509; rs36097152; rs28564011; rs10181380; rs5838513; rs16853904; rs9749692; rs6743670; rs41347752; rs9751656; rs13026921; rs35976930; rs35034272; rs10534431; rs34066120; rs34085634; rs34576780; rs13017248; rs10648691; rs5838511; rs1250266; rs1968508; rs1250257; rs10542238; rs10559309; rs11897227; rs1250251; rs34656990; rs2577300; rs13306367; rs10168572; rs13394972; rs3832178; rs34162130; rs11889491; rs35639338; rs2372541; rs28631799; rs34087019; rs34317431; rs35609230; rs34325359; rs7606467; rs10179937; rs10202709; rs34595854; rs35492653; rs34345666; rs35754566; rs9751659; rs35780063; rs5838503; rs13431830; rs1313044; rs6729046; rs6727989; rs35233997; rs34645626; rs7565821; rs10524797; rs5838512; rs2438173; rs36098055; rs34156003; rs1250208; rs35545936; rs5838504; rs10648148; rs1250216; rs11411384; rs11376297; rs36066561; rs1250206; rs1250263; rs7556883; rs3051917; rs1250265; rs35437250; rs35258787; rs10679143; rs7558917; rs13306371; rs12621043; rs4393746; rs35494414; rs16853944; rs34173232; rs34314527; rs5838507; rs11358448; rs2177736; rs34245778; rs10649966; rs10614770; rs2577296; rs34947596; rs10577918; rs9751655; rs33963377; rs13306368; rs16853844; rs16853861; rs34147750; rs2372543; rs11315848; rs5838508; rs11350861; rs1437794; rs35440741; rs6712858; rs5838515; rs5838501; rs11897252; rs34140794; rs13427569; rs13015576; rs5838510; rs35967269; rs35143823; rs2289201; rs34196672; rs10611390; rs13001466; rs6738126; rs7562601; rs13409661; rs6738148; rs5838516; rs13023606; rs10599084; rs28365987; rs35118035; rs10180997; rs1250227; rs1250228; rs1250229; rs1250230; rs1250232; rs1250233; rs1250234; rs1250235; rs1250237; rs12999909; rs13027307; rs2577292; rs2692225; rs3910516; rs4473378; rs6706415; rs6725921; rs6735789; rs7562597; rs7588799; rs7596482; rs7604984

# Macromolecular_Interacting_Partner_7_General_References:
11737888; 3770189; 3031656; 2992939; 3900070; 6462919; 3375063; 2822387; 3478690; 7050098; 6688418; 3003095; 3593230; 2992573; 6200322; 3021206; 12127832; 2989004; 3770201; 4019516; 6304699; 6630202; 3024962; 2414772; 2012601; 1400330; 7989369; 9501082; 1311202; 1423622; 8308892; 7583666; 9514732; 10196121; 10647176; 11285216; 11775745; 12736686; 8120888; 8548820; 10075919

# Macromolecular_Interacting_Partner_7_References:
16876110

# Macromolecular_Interacting_Partner_8_ID:
7556

# Macromolecular_Interacting_Partner_8_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_8_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_8_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_8_Signals:
1-18

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_8_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_8_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_8_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_8_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_8_References:
16476848; 16572107; 16671338

# Macromolecular_Interacting_Partner_9_ID:
7297

# Macromolecular_Interacting_Partner_9_Name:
Glucocorticoid receptor

# Macromolecular_Interacting_Partner_9_Synonyms:
GR

# Macromolecular_Interacting_Partner_9_Gene_Name:
NR3C1

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Glucocorticoid receptor
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
777

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
85660

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
6.31

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  transcription factor activity
Function:  steroid binding
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  glucocorticoid receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Receptor for glucocorticoids (GC). Has a dual mode of action:as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF02155:GCR;
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_9_Signals:
None

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
31680

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
GCR_HUMAN (P04150)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
NR3C1

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
NR3C1

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:7978

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>2334 bp
ATGGACTCCAAAGAATCATTAACTCCTGGTAGAGAAGAAAACCCCAGCAGTGTGCTTGCT
CAGGAGAGGGGAGATGTGATGGACTTCTATAAAACCCTAAGAGGAGGAGCTACTGTGAAG
GTTTCTGCGTCTTCACCCTCACTGGCTGTCGCTTCTCAATCAGACTCCAAGCAGCGAAGA
CTTTTGGTTGATTTTCCAAAAGGCTCAGTAAGCAATGCGCAGCAGCCAGATCTGTCCAAA
GCAGTTTCACTCTCAATGGGACTGTATATGGGAGAGACAGAAACAAAAGTGATGGGAAAT
GACCTGGGATTCCCACAGCAGGGCCAAATCAGCCTTTCCTCGGGGGAAACAGACTTAAAG
CTTTTGGAAGAAAGCATTGCAAACCTCAATAGGTCGACCAGTGTTCCAGAGAACCCCAAG
AGTTCAGCATCCACTGCTGTGTCTGCTGCCCCCACAGAGAAGGAGTTTCCAAAAACTCAC
TCTGATGTATCTTCAGAACAGCAACATTTGAAGGGCCAGACTGGCACCAACGGTGGCAAT
GTGAAATTGTATACCACAGACCAAAGCACCTTTGACATTTTGCAGGATTTGGAGTTTTCT
TCTGGGTCCCCAGGTAAAGAGACGAATGAGAGTCCTTGGAGATCAGACCTGTTGATAGAT
GAAAACTGTTTGCTTTCTCCTCTGGCGGGAGAAGACGATTCATTCCTTTTGGAAGGAAAC
TCGAATGAGGACTGCAAGCCTCTCATTTTACCGGACACTAAACCCAAAATTAAGGATAAT
GGAGATCTGGTTTTGTCAAGCCCCAGTAATGTAACACTGCCCCAAGTGAAAACAGAAAAA
GAAGATTTCATCGAACTCTGCACCCCTGGGGTAATTAAGCAAGAGAAACTGGGCACAGTT
TACTGTCAGGCAAGCTTTCCTGGAGCAAATATAATTGGTAATAAAATGTCTGCCATTTCT
GTTCATGGTGTGAGTACCTCTGGAGGACAGATGTACCACTATGACATGAATACAGCATCC
CTTTCTCAACAGCAGGATCAGAAGCCTATTTTTAATGTCATTCCACCAATTCCCGTTGGT
TCCGAAAATTGGAATAGGTGCCAAGGATCTGGAGATGACAACTTGACTTCTCTGGGGACT
CTGAACTTCCCTGGTCGAACAGTTTTTTCTAATGGCTATTCAAGCCCCAGCATGAGACCA
GATGTAAGCTCTCCTCCATCCAGCTCCTCAACAGCAACAACAGGACCACCTCCCAAACTC
TGCCTGGTGTGCTCTGATGAAGCTTCAGGATGTCATTATGGAGTCTTAACTTGTGGAAGC
TGTAAAGTTTTCTTCAAAAGAGCAGTGGAAGGACAGCACAATTACCTATGTGCTGGAAGG
AATGATTGCATCATCGATAAAATTCGAAGAAAAAACTGCCCAGCATGCCGCTATCGAAAA
TGTCTTCAGGCTGGAATGAACCTGGAAGCTCGAAAAACAAAGAAAAAAATAAAAGGAATT
CAGCAGGCCACTACAGGAGTCTCACAAGAAACCTCTGAAAATCCTGGTAACAAAACAATA
GTTCCTGCAACGTTACCACAACTCACCCCTACCCTGGTGTCACTGTTGGAGGTTATTGAA
CCTGAAGTGTTATATGCAGGATATGATAGCTCTGTTCCAGACTCAACTTGGAGGATCATG
ACTACGCTCAACATGTTAGGAGGGCGGCAAGTGATTGCAGCAGTGAAATGGGCAAAGGCA
ATACCAGGTTTCAGGAACTTACACCTGGATGACCAAATGACCCTACTGCAGTACTCCTGG
ATGTTTCTTATGGCATTTGCTCTGGGGTGGAGATCATATAGACAATCAAGTGCAAACCTG
CTGTGTTTTGCTCCTGATCTGATTATTAATGAGCAGAGAATGACTCTACCCTGCATGTAC
GACCAATGTAAACACATGCTGTATGTTTCCTCTGAGTTACACAGGCTTCAGGTATCTTAT
GAAGAGTATCTCTGTATGAAAACCTTACTGCTTCTCTCTTCAGTTCCTAAGGACGGTCTG
AAGAGCCAAGAGCTATTTGATGAAATTAGAATGACCTACATCAAAGAGCTAGGAAAAGCC
ATTGTCAAGAGGGAAGGAAACTCCAGCCAGAACTGGCAGCGGTTTTATCAACTGACAAAA
CTCTTGGATTCTATGCATGAAGTGGTTGAAAATCTCCTTAACTATTGCTTCCAAACATTT
TTGGATAAGACCATGAGTATTGAATTCCCCGAGATGTTAGCTGAAATCATCACCAATCAG
ATACCAAAATATTCAAATGGAAATATCAAAAAACTTCTGTTTCATCAAAAGTGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
X03225

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_9_Locus:
5q31.3

# Macromolecular_Interacting_Partner_9_SNPs:
rs6192; rs6190; rs6195; rs6196; rs6189; rs6194; rs258751; rs6199; rs6193; rs4912910; rs6191; rs10052957; rs7701443; rs4912909; rs12656106; rs4607376; rs4244032; rs4403203; rs9324924; rs5871845; rs4912911; rs9324922; rs6198; rs10482605; rs10477211; rs13185164; rs13162395; rs4529231; rs4582314; rs4244031; rs10482611; rs10482620; rs12513857; rs6865292; rs4457111; rs9324923; rs4634384; rs11167811; rs6896209; rs4518434; rs12655166; rs10482609; rs4912912; rs10482616; rs11749561; rs13182800; rs10482603; rs10482617; rs10482707; rs17302697; rs10482610; rs10482714; rs4406157; rs7719514; rs17100289; rs6197; rs3806854; rs13186836; rs4518436; rs7723528; rs10482614; rs13170129; rs6882102; rs28364694; rs13153270; rs10482712; rs13155635; rs11747997; rs12653301; rs10043090; rs13184611; rs11167810; rs10482716; rs2301177; rs3806855; rs12054797; rs12515985; rs2918417; rs2918416; rs1866388; rs852980; rs33388; rs258813; rs6188; rs2963156; rs258750; rs852977; rs2918418; rs6877893; rs4986593; rs9324915; rs6866890; rs852982; rs1438732; rs2918419; rs9324914; rs10041520; rs12652915; rs10078410; rs4912905; rs10054283; rs852978; rs864082; rs33389; rs17209251; rs10482625; rs9324916; rs852976; rs10515522; rs2043840; rs10482655; rs2963145; rs9324918; rs12386466; rs11740792; rs11955803; rs9324917; rs2963152; rs9324921; rs4128428; rs10042644; rs258814; rs2118727; rs2398631; rs9324913; rs10482640; rs13355103; rs4912650; rs10482641; rs10482665; rs9324920; rs10482634; rs10482636; rs6871322; rs7716360; rs17100234; rs11745958; rs9324912; rs17339831; rs10482650; rs13358709; rs10482682; rs1438731; rs2963146; rs10515521; rs9324911; rs10482633; rs190488; rs852981; rs10482672; rs10482642; rs10482637; rs13306587; rs852979; rs10482630; rs13176292; rs2918415; rs10066267; rs10482646; rs10482668; rs17100236; rs10482669; rs10482654; rs10482679; rs10482704; rs10076665; rs2963155; rs11740747; rs10482631; rs17209258; rs4912907; rs10482676; rs10482681; rs2918421; rs10482701; rs10482688; rs10482638; rs10482689; rs13360865; rs1837262; rs17339455; rs10482686; rs13360160; rs10482667; rs13353867; rs10072193; rs10071869; rs10038016; rs852975; rs13171962; rs10482700; rs10482643; rs12109552; rs11750172; rs10045381; rs10482658; rs10055443; rs10041957; rs10042903; rs17399352; rs10482626; rs10482653; rs7730946; rs10076037; rs10482675; rs13178847; rs6861962; rs2963151; rs10040972; rs10042897; rs10042042; rs10053679; rs33380; rs10482659; rs2307674; rs3776216; rs10482690; rs13186482; rs10482628; rs10041040; rs13180461; rs2963154; rs12655424; rs9324919; rs10060545; rs10482645; rs1305061; rs11742942; rs3822376; rs34562334; rs10043707; rs10482698; rs10055444; rs10051482; rs10482693; rs10482623; rs10482683; rs17100237; rs13353891; rs13361140; rs10482639; rs2963149; rs10038464; rs860457; rs258747; rs6868190; rs17287758; rs258748; rs17209237; rs33391; rs1800445; rs10482622; rs13306589; rs13306588; rs13160969; rs11292842; rs10482621; rs10482618; rs35515833; rs13166252; rs10482608; rs13173940; rs10482606; rs35257270; rs10477210; rs5871844; rs5871846; rs34113205; rs13306586; rs4585488; rs34519266; rs6187; rs35726834; rs28546630; rs10482619; rs10482612; rs13306585; rs33978809; rs34580792; rs13166717; rs33968115; rs35132206; rs4244033; rs34123577; rs10482711; rs10482706; rs35956102; rs4441905; rs4075426; rs35159833; rs28392717; rs35174661; rs4912908; rs10577951; rs36208514; rs34471178; rs10482708; rs35314635; rs36028129; rs28635164; rs4367320; rs35715139; rs34248080; rs10482613; rs34027900; rs10482709; rs10482713; rs35555700; rs35500391; rs34449288; rs6894830; rs35728985; rs10482710; rs10482604; rs13178409; rs34207899; rs12652149; rs10482607; rs34226461; rs13176328; rs1803634; rs34861052; rs10440742; rs35224915; rs35722527; rs4434414; rs5871847; rs13169606; rs36029993; rs35296125; rs12189168; rs34569272; rs10482615; rs35612073; rs34961947; rs35290813; rs28609103; rs10043662; rs4388235; rs34396341; rs10482715; rs36208517; rs11552272; rs5871843; rs35572256; rs10482657; rs10482691; rs13158118; rs10038827; rs34523349; rs35918104; rs35271349; rs10043423; rs4912906; rs10477206; rs10482661; rs2398628; rs10482678; rs35786621; rs10482677; rs33963148; rs35947578; rs13358784; rs10482680; rs35598337; rs35023410; rs35592572; rs9654496; rs13169116; rs13359753; rs13356889; rs10053963; rs10477207; rs35020221; rs34756958; rs36027185; rs35396295; rs34641849; rs10037525; rs34808627; rs174050; rs2079687; rs34530390; rs10482644; rs3836768; rs28865014; rs4608948; rs34209560; rs10039663; rs10482647; rs10482670; rs10477208; rs860458; rs34841797; rs13169117; rs2963147; rs36008199; rs10042038; rs34427874; rs10482697; rs2963150; rs3861852; rs35245606; rs35176817; rs10062225; rs10477209; rs34535209; rs10482629; rs10073248; rs34319493; rs2022117; rs34780316; rs10482660; rs35624123; rs35302985; rs35299297; rs10482635; rs1140000; rs13306584; rs34194480; rs7715728; rs34260076; rs7734158; rs10482649; rs28822503; rs34638922; rs36090270; rs28453280; rs10045200; rs34152766; rs10482696; rs34346366; rs34743734; rs10055574; rs35527602; rs10035222; rs36010586; rs10037693; rs10482664; rs10482684; rs10482652; rs10482627; rs28821527; rs10482673; rs10482674; rs10482703; rs2963148; rs10060741; rs10482695; rs10053200; rs41423247; rs35655055; rs852974; rs10054713; rs10482624; rs34827388; rs34686112; rs10482692; rs35667604; rs10482694; rs35039262; rs2398629; rs34992369; rs10482687; rs35713866; rs10482685; rs2918420; rs10482666; rs35502804; rs10482648; rs10477204; rs33952897; rs36027730; rs34778988; rs10036278; rs2282800; rs11395012; rs33382; rs10042945; rs13361442; rs10036628; rs35923465; rs35999293; rs35241746; rs10214015; rs4912904; rs10041074; rs6882247; rs28791803; rs10482662; rs10482699; rs34186246; rs34494535; rs35434651; rs10482671; rs10482632; rs10482705; rs13355270; rs33944801; rs34632939; rs2963153; rs33381; rs35507823; rs34176759; rs34763421; rs10482656; rs34340042; rs10482702; rs10065326; rs6873841; rs36105398; rs10482651; rs35696265; rs185434; rs10079976; rs10036734; rs35335992; rs11378193; rs34911720; rs10482663; rs4437403; rs34019216; rs35067504; rs10482717; rs34876003; rs10041406; rs12519083; rs12521436; rs13190019; rs17287745; rs174048; rs258763; rs33383; rs4912913; rs7448383; rs7701582; rs7709864; rs7728835

# Macromolecular_Interacting_Partner_9_General_References:
2867473; 1707881; 2026589; 1958537; 11435610; 3841189; 9154805; 9590696; 10477749; 10566686; 8358712; 10902803; 10866662; 10639135; 11555652; 11238589; 12144530; 12000743; 12415108; 12151000; 12686538; 1704018; 8358735; 8445027; 7683692; 8316249; 9150737; 10391209; 10898924; 11589680; 11344238; 11701741; 11932321; 12050230

# Macromolecular_Interacting_Partner_9_References:
15919070

# Macromolecular_Interacting_Partner_10_ID:
7258

# Macromolecular_Interacting_Partner_10_Name:
Plasminogen activator inhibitor 1 precursor

# Macromolecular_Interacting_Partner_10_Synonyms:
PAI-1; Endothelial plasminogen activator inhibitor; PAI

# Macromolecular_Interacting_Partner_10_Gene_Name:
SERPINE1

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Plasminogen activator inhibitor 1 precursor
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
402

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
45061

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
7.22

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  protease inhibitor activity
Function:  endopeptidase inhibitor activity
Function:  serine-type endopeptidase inhibitor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00079:Serpin

# Macromolecular_Interacting_Partner_10_Signals:
1-23

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
35272

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
PAI1_HUMAN (P05121)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
SERPINE1

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
SERPINE1

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:8583

# Macromolecular_Interacting_Partner_10_PDB_ID:
1C5G

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>1209 bp
ATGCAGATGTCTCCAGCCCTCACCTGCCTAGTCCTGGGCCTGGCCCTTGTCTTTGGTGAA
GGGTCTGCTGTGCACCATCCCCCATCCTACGTGGCCCACCTGGCCTCAGACTTCGGGGTG
AGGGTGTTTCAGCAGGTGGCGCAGGCCTCCAAGGACCGCAACGTGGTTTTCTCACCCTAT
GGGGTGGCCTCGGTGTTGGCCATGCTCCAGCTGACAACAGGAGGAGAAACCCAGCAGCAG
ATTCAAGCAGCTATGGGATTCAAGATTGATGACAAGGGCATGGCCCCCGCCCTCCGGCAT
CTGTACAAGGAGCTCATGGGGCCATGGAACAAGGACGAGATCAGCACCACAGACGCGATC
TTCGTCCAGCGGGATCTGAAGCTGGTCCAGGGCTTCATGCCCCACTTCTTCAGGCTGTTC
CGGAGCACGGTCAAGCAAGTGGACTTTTCAGAGGTGGAGAGAGCCAGATTCATCATCAAT
GACTGGGTGAAGACACACACAAAAGGTATGATCAGCAACTTGCTTGGGAAAGGAGCCGTG
GACCAGCTGACACGGCTGGTGCTGGTGAATGCCCTCTACTTCAACGGCCAGTGGAAGACT
CCCTTCCCCGACTCCAGCACCCACCGCCGCCTCTTCCACAAATCAGACGGCAGCACTGTC
TCTGTGCCCATGATGGCTCAGACCAACAAGTTCAACTATACTGAGTTCACCACGCCCGAT
GGCCATTACTACGACATCCTGGAACTGCCCTACCACGGGGACACCCTCAGCATGTTCATT
GCTGCCCCTTATGAAAAAGAGGTGCCTCTCTCTGCCCTCACCAACATTCTGAGTGCCCAG
CTCATCAGCCACTGGAAAGGCAACATGACCAGGCTGCCCCGCCTCCTGGTTCTGCCCAAG
TTCTCCCTGGAGACTGAAGTCGACCTCAGGAAGCCCCTAGAGAACCTGGGAATGACCGAC
ATGTTCAGACAGTTTCAGGCTGACTTCACGAGTCTTTCAGACCAAGAGCCTCTCCACGTC
GCGCAGGCGCTGCAGAAAGTGAAGATCGAGGTGAACGAGAGTGGCACGGTGGCCTCCTCA
TCCACAGCTGTCATAGTCTCAGCCCGCATGGCCCCCGAGGAGATCATCATGGACAGACCC
TTCCTCTTTGTGGTCCGGCACAACCCCACAGGAACAGTCCTTTTCATGGGCCAAGTGATG
GAACCCTGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
X04429

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_10_Locus:
7q21.3-q22

# Macromolecular_Interacting_Partner_10_SNPs:
rs6090; rs6092; rs6091; rs1050813; rs11178; rs7242; rs2227636; rs2227714; rs2227698; rs2227716; rs2227700; rs7241; rs41423845; rs2227695; rs2227639; rs2227645; rs2227635; rs2227696; rs2227644; rs2227637; rs15196; rs2227699; rs1050766; rs2227692; rs2227683; rs2227657; rs2227674; rs2227673; rs2227690; rs2070682; rs2227677; rs2227663; rs2227711; rs2227694; rs2227672; rs2070683; rs2227682; rs2227667; rs2227684; rs2227691; rs2227660; rs2227693; rs1029528; rs2227678; rs2227686; rs2227654; rs2227648; rs2227658; rs2227653; rs2227659; rs2227662; rs2227710; rs2227676; rs2227679; rs6089; rs2227666; rs2227665; rs2227708; rs2227652; rs11976650; rs2227668; rs2227675; rs2227712; rs2227687; rs7788294; rs2227651; rs2227681; rs2227649; rs2227631; rs2227633; rs1050955; rs2227630; rs2227702; rs2227707; rs2227703; rs2227629; rs2227632; rs13306846; rs2227647; rs2227685; rs2227669; rs2227670; rs3177930; rs13306847; rs2854229; rs2227646; rs2854230; rs1801003; rs2227641; rs13230881; rs3209821; rs2227640; rs11553532; rs2227638; rs13306842; rs11553533; rs41334349; rs36228265; rs2227643; rs35674524; rs13306843; rs2227715; rs13306844; rs34950159; rs2227697; rs2227655; rs5886162; rs10274922; rs3020620; rs3071566; rs28503992; rs10563759; rs2227689; rs10249874; rs41281004; rs35391004; rs35447707; rs3020624; rs13306845; rs6959054; rs2227671; rs11279877; rs34817294; rs2227661; rs34814785; rs2227713; rs12535050; rs36172384; rs2227650; rs35467518; rs34384835; rs36051604; rs10600557; rs35764880; rs35459889; rs2227680; rs28460262; rs3020623; rs11409368; rs34132647; rs28695455; rs2854233; rs2227656; rs2854236; rs35399649; rs11375202; rs3020621; rs10265348; rs2227664; rs2227709; rs41432746; rs35952770; rs3020622; rs10577575; rs2527317; rs13240413; rs2227688; rs34472055; rs11272706; rs10563102; rs10582824; rs5886163; rs36227923; rs2227701; rs33997895; rs36228273; rs11553535; rs36114456; rs2227634; rs36228272; rs36228264; rs34857375; rs1799762; rs36228271; rs1799768; rs36228269; rs11416893; rs10228765; rs10243267; rs10281013; rs11560324; rs12534508; rs12536798; rs12540843; rs12673157; rs13238709; rs17135252; rs2227705; rs2854225; rs2854226; rs2854235; rs34144144; rs34699890; rs4727479; rs4729664; rs6465787; rs6950982; rs6956010; rs757716

# Macromolecular_Interacting_Partner_10_General_References:
2430793; 2820474; 3097076; 2612914; 3262512; 3132455; 12853948; 3092219; 3025016; 3026837; 7522053; 11384978; 1731226; 7552714; 9634700; 10368279; 10731421; 9194591; 10391209

# Macromolecular_Interacting_Partner_10_References:
15488878; 15576638; 17142138

# Macromolecular_Interacting_Partner_11_ID:
7570

# Macromolecular_Interacting_Partner_11_Name:
Endothelin-1 precursor

# Macromolecular_Interacting_Partner_11_Synonyms:
Preproendothelin-1; PPET1[Contains: Endothelin-1; ET-1; Big endothelin-1]

# Macromolecular_Interacting_Partner_11_Gene_Name:
EDN1

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Endothelin1 precursor
MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMD
KECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCW
NFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSE
TMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
212

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
24425

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
9.92

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  interaction between organisms
Process:  interspecies interaction between organisms
Process:  symbiosis, encompassing mutualism through parasitism
Process:  pathogenesis
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of organismal physiological process
Process:  regulation of vasoconstriction
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_11_General_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Specific_Function:
Endothelins are endothelium-derived vasoconstrictor peptides

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF00322:Endothelin

# Macromolecular_Interacting_Partner_11_Signals:
1-17

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
31255

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
EDN1_HUMAN (P05305)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
EDN1

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
EDN1

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:3176

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>639 bp
ATGGATTATTTGCTCATGATTTTCTCTCTGCTGTTTGTGGCTTGCCAAGGAGCTCCAGAA
ACAGCAGTCTTAGGCGCTGAGCTCAGCGCGGTGGGTGAGAACGGCGGGGAGAAACCCACT
CCCAGTCCACCCTGGCGGCTCCGCCGGTCCAAGCGCTGCTCCTGCTCGTCCCTGATGGAT
AAAGAGTGTGTCTACTTCTGCCACCTGGACATCATTTGGGTCAACACTCCCGAGCACGTT
GTTCCGTATGGACTTGGAAGCCCTAGGTCCAAGAGAGCCTTGGAGAATTTACTTCCCACA
AAGGCAACAGACCGTGAGAATAGATGCCAATGTGCTAGCCAAAAAGACAAGAAGTGCTGG
AATTTTTGCCAAGCAGGAAAAGAACTCAGGGCTGAAGACATTATGGAGAAAGACTGGAAT
AATCATAAGAAAGGAAAAGACTGTTCCAAGCTTGGGAAAAAGTGTATTTATCAGCAGTTA
GTGAGAGGAAGAAAAATCAGAAGAAGTTCAGAGGAACACCTAAGACAAACCAGGTCGGAG
ACCATGAGAAACAGCGTCAAATCATCTTTTCATGATCCCAAGCTGAAAGGCAAGCCCTCC
AGAGAGCGTTATGTGACCCACAACCGAGCACATTGGTGA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
Y00749

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_11_Locus:
6p24.1

# Macromolecular_Interacting_Partner_11_SNPs:
Not Available

# Macromolecular_Interacting_Partner_11_General_References:
3282927; 2670930; 2659594; 8450044; 14574404; 2649896; 1864385; 9284755; 1515112; 7664037; 1859417; 1736987; 1422154; 7773179; 10231710; 10334806; 10391210

# Macromolecular_Interacting_Partner_11_References:
15808081; 16313806; 16333235; 16915013

# Macromolecular_Interacting_Partner_12_ID:
7577

# Macromolecular_Interacting_Partner_12_Name:
Calcitonin gene-related peptide 1 precursor

# Macromolecular_Interacting_Partner_12_Synonyms:
Calcitonin gene-related peptide I; CGRP-I; Alpha-type CGRP

# Macromolecular_Interacting_Partner_12_Gene_Name:
CALCA

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Calcitonin generelated peptide 1 precursor
MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQ
MKASELEQEQEREGSRIIAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFG
RRRRDLQA

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
128

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
13899

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
9.40

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF00214:Calc_CGRP_IAPP

# Macromolecular_Interacting_Partner_12_Signals:
1-25

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
179828

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
CALCA_HUMAN (P06881)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
CALCA

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
CALCA

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:1437

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>387 bp
ATGGGCTTCCAAAAGTTCTCCCCCTTCCTGGCTCTCAGCATCTTGGTCCTGTTGCAGGCA
GGCAGCCTCCATGCAGCACCATTCAGGTCTGCCCTGGAGAGCAGCCCAGCAGACCCGGCC
ACGCTCAGTGAGGACGAAGCGCGCCTCCTGCTGGCTGCACTGGTGCAGGACTATGTGCAG
ATGAAGGCCAGTGAGCTGGAGCAGGAGCAAGAGAGAGAGGGCTCCAGAATCATTGCCCAG
AAGAGAGCCTGTGACACTGCCACCTGTGTGACTCATCGGCTGGCAGGCTTGCTGAGCAGA
TCAGGGGGTGTGGTGAAGAACAACTTTGTGCCCACCAATGTGGGTTCCAAAGCCTTTGGC
AGGCGCCGCAGGGACCTTCAAGCCTGA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
M12667

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_12_Locus:
11p15.2-p15.1

# Macromolecular_Interacting_Partner_12_SNPs:
rs13306224; rs5241; rs5239; rs5240; rs5242; rs2956; rs7110615; rs5237; rs5243; rs2644690; rs35815751; rs5238; rs11607133; rs34901084; rs7925191; rs34294892; rs35212698; rs35909067; rs34815547; rs35731970; rs3758761; rs11023401; rs3781719; rs3781718; rs1553005; rs35365543; rs924099; rs11826691; rs11023400; rs34414857; rs34164367; rs34587547; rs34670162; rs2644689; rs35709504; rs35425520; rs7124346; rs2644687; rs34896084; rs35943755; rs35096144; rs2644688; rs13306223; rs2856867; rs34200140; rs35996804; rs35356387; rs34603621; rs34488736; rs35780811; rs2856866; rs1010042; rs12576047; rs34252928; rs2071411; rs7114837; rs34692826; rs7128563; rs28420578; rs12361439; rs34468174; rs13306225; rs11821926; rs1908683; rs34166188; rs35006116; rs35676062; rs35096190; rs12800646; rs35955129; rs35481990; rs28494031; rs34691228; rs12800297; rs12225355; rs12800139; rs34596504; rs1027425; rs1027426; rs1027427; rs10832338; rs11023403; rs11608134; rs11821055; rs11825513; rs11827349; rs1496163; rs1496166; rs16930769; rs16930770; rs16930784; rs17503142; rs763363; rs7929159; rs7948017; rs903808

# Macromolecular_Interacting_Partner_12_General_References:
3872459; 2571128; 6148938; 2408883; 6610687; 3034287; 6609312; 3492492; 1318039; 1988044; 2039456

# Macromolecular_Interacting_Partner_12_References:
16458982

# Macromolecular_Interacting_Partner_13_ID:
7263

# Macromolecular_Interacting_Partner_13_Name:
Small inducible cytokine A2 precursor

# Macromolecular_Interacting_Partner_13_Synonyms:
CCL2; Monocyte chemotactic protein 1; MCP-1; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte secretory protein JE; HC11

# Macromolecular_Interacting_Partner_13_Gene_Name:
CCL2

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Small inducible cytokine A2 precursor
MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCP
KEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
99

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
11025

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
9.72

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  chemokine activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane
Component:  extracellular region

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF00048:IL8

# Macromolecular_Interacting_Partner_13_Signals:
1-23

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
307163

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
CCL2_HUMAN (P13500)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
CCL2

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
CCL2

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:10618

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>300 bp
ATGAAAGTCTCTGCCGCCCTTCTGTGCCTGCTGCTCATAGCAGCCACCTTCATTCCCCAA
GGGCTCGCTCAGCCAGATGCAATCAATGCCCCAGTCACCTGCTGTTATAACTTCACCAAT
AGGAAGATCTCAGTGCAGAGGCTCGCGAGCTATAGAAGAATCACCAGCAGCAAGTGTCCC
AAAGAAGCTGTGATCTTCAAGACCATTGTGGCCAAGGAGATCTGTGCTGACCCCAAGCAG
AAGTGGGTTCAGGATTCCATGGACCACCTGGACAAGCAAACCCAAACTCCGAAGACTTGA


# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
M24545

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_13_Locus:
17q11.2-q12

# Macromolecular_Interacting_Partner_13_SNPs:
rs4586; rs13900; rs2215182; rs2857657; rs3917887; rs28730833; rs2857656; rs2190971; rs2857655; rs3760399; rs3091332; rs3917886; rs11575012; rs11575011; rs3760396; rs13306749; rs13306748; rs13306750; rs41507946; rs3917888; rs34095515; rs3760398; rs11575010; rs2190972; rs36231142; rs3917904; rs1014542; rs3760397; rs1024610; rs1024611; rs1080327; rs11575013; rs11575018; rs11652475; rs11652585; rs11655761; rs11656026; rs11656271; rs11867200; rs11870347; rs17652343; rs1860188; rs1860189; rs1860190; rs1989055; rs2530797; rs2857653; rs2857654; rs3091315; rs3091316; rs3917878; rs3917883; rs3917891; rs3917894; rs3917895; rs4795893; rs4795894; rs6505402; rs7210316; rs7503519; rs8068314; rs8074043; rs8079288; rs991804

# Macromolecular_Interacting_Partner_13_General_References:
2923622; 2513477; 2465924; 2518726; 2357211; 1661560; 8107690; 10918580; 2648385; 2322286; 2071154; 8195247; 8627182; 8898111; 1857712; 8639605; 8989326

# Macromolecular_Interacting_Partner_13_References:
16174286; 16571782

# Macromolecular_Interacting_Partner_14_ID:
7620

# Macromolecular_Interacting_Partner_14_Name:
Natriuretic peptides B precursor [Contains: Gamma-brain natriuretic peptide; Brain natriuretic peptide 32

# Macromolecular_Interacting_Partner_14_Synonyms:
BNP-32]

# Macromolecular_Interacting_Partner_14_Gene_Name:
NPPB

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>Natriuretic peptides B precursor Contains: Gammabrain natriuretic peptide; Brain natriuretic peptide 32
MDPQTAPSRALLLLLFLHLAFLGGRSHPLGSPGSASDLETSGLQEQRNHLQGKLSELQVE
QTSLEPLQESPRPTGVWKSREVATEGIRGHRKMVLYTLRAPRSPKMVQGSGCFGRKMDRI
SSSSGLGCKVLRRH

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
134

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
14726

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
11.01

# Macromolecular_Interacting_Partner_14_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_14_General_Function:
Not Available

# Macromolecular_Interacting_Partner_14_Specific_Function:
Acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. Helps restore the body's salt and water balance. Improves heart function

# Macromolecular_Interacting_Partner_14_Pathway:
Not Available

# Macromolecular_Interacting_Partner_14_Reaction:
Not Available

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF00212:ANP

# Macromolecular_Interacting_Partner_14_Signals:
1-26

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
179515

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
ANFB_HUMAN (P16860)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
NPPB

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
NPPB

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:7940

# Macromolecular_Interacting_Partner_14_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>405 bp
ATGGATCCCCAGACAGCACCTTCCCGGGCGCTCCTGCTCCTGCTCTTCTTGCATCTGGCT
TTCCTGGGAGGTCGTTCCCACCCGCTGGGCAGCCCCGGTTCAGCCTCGGACTTGGAAACG
TCCGGGTTACAGGAGCAGCGCAACCATTTGCAGGGCAAACTGTCGGAGCTGCAGGTGGAG
CAGACATCCCTGGAGCCCCTCCAGGAGAGCCCCCGTCCCACAGGTGTCTGGAAGTCCCGG
GAGGTAGCCACCGAGGGCATCCGTGGGCACCGCAAAATGGTCCTCTACACCCTGCGGGCA
CCACGAAGCCCCAAGATGGTGCAAGGGTCTGGCTGCTTTGGGAGGAAGATGGACCGGATC
AGCTCCTCCAGTGGCCTGGGCTGCAAAGTGCTGAGGCGGCATTAA

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
M31776

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_14_Locus:
1p36.2

# Macromolecular_Interacting_Partner_14_SNPs:
rs5227; rs5229; rs35628673; rs5228; rs198389; rs198381; rs198388; rs6541007; rs3753581; rs198386; rs549596; rs198387; rs35640285; rs5230; rs35690395; rs13305989; rs35519114; rs35207557; rs35458601; rs3831247; rs34331786; rs13305990; rs616308; rs198380; rs12124640; rs13305991; rs35533748; rs12047640; rs12121986; rs12118667; rs35587340; rs1003632; rs1009591; rs1009592; rs1076626; rs11801879; rs11802855; rs11803049; rs12029160; rs12091159; rs12402363; rs12406089; rs12406383; rs12562819; rs12562952; rs12753716; rs1318408; rs13305986; rs17376426; rs1800773; rs198372; rs198373; rs198375; rs4846061; rs5063; rs5064; rs632793; rs6668352; rs6668659; rs6676300; rs6694164; rs6695740

# Macromolecular_Interacting_Partner_14_General_References:
2597152; 2522777; 2138890; 2136732

# Macromolecular_Interacting_Partner_14_References:
16298263

# Macromolecular_Interacting_Partner_15_ID:
6559

# Macromolecular_Interacting_Partner_15_Name:
Mitogen-activated protein kinase 3

# Macromolecular_Interacting_Partner_15_Synonyms:
Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAPK 1; p44-ERK1; ERT2; p44-MAPK; Microtubule- associated protein 2 kinase

# Macromolecular_Interacting_Partner_15_Gene_Name:
MAPK3

# Macromolecular_Interacting_Partner_15_Protein_Sequence:
>Mitogenactivated protein kinase 3
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP

# Macromolecular_Interacting_Partner_15_Number_of_Residues:
379

# Macromolecular_Interacting_Partner_15_Molecular_Weight:
43136

# Macromolecular_Interacting_Partner_15_Theoretical_pI:
6.74

# Macromolecular_Interacting_Partner_15_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_15_General_Function:
Not Available

# Macromolecular_Interacting_Partner_15_Specific_Function:
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1

# Macromolecular_Interacting_Partner_15_Pathway:
Not Available

# Macromolecular_Interacting_Partner_15_Reaction:
Not Available

# Macromolecular_Interacting_Partner_15_Pfam_Domain_Function:
PF00069:Pkinase

# Macromolecular_Interacting_Partner_15_Signals:
None

# Macromolecular_Interacting_Partner_15_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_15_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_15_EC_Link:
EC 2.7.11.24

# Macromolecular_Interacting_Partner_15_GenBank_ID_Protein:
31221

# Macromolecular_Interacting_Partner_15_SwissProt_ID:
MK03_HUMAN (P27361)

# Macromolecular_Interacting_Partner_15_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_15_Genecard_id:
MAPK3

# Macromolecular_Interacting_Partner_15_Geneatlas_id:
MAPK3

# Macromolecular_Interacting_Partner_15_hgnc_id:
HGNC:6877

# Macromolecular_Interacting_Partner_15_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_15_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_15_Gene_Sequence:
>1140 bp
ATGGCGGCGGCGGCGGCTCAGGGGGGCGGGGGCGGGGAGCCCCGTAGAACCGAGGGGGTC
GGCCCGGGGGTCCCGGGGGAGGTGGAGATGGTGAAGGGGCAGCCGTTCGACGTGGGCCCG
CGCTACACGCAGTTGCAGTACATCGGCGAGGGCGCGTACGGCATGGTCAGCTCGGCCTAT
GACCACGTGCGCAAGACTCGCGTGGCCATCAAGAAGATCAGCCCCTTCGAACATCAGACC
TACTGCCAGCGCACGCTCCGGGAGATCCAGATCCTGCTGCGCTTCCGCCATGAGAATGTC
ATCGGCATCCGAGACATTCTGCGGGCGTCCACCCTGGAAGCCATGAGAGATGTCTACATT
GTGCAGGACCTGATGGAGACTGACCTGTACAAGTTGCTGAAAAGCCAGCAGCTGAGCAAT
GACCATATCTGCTACTTCCTCTACCAGATCCTGCGGGGCCTCAAGTACATCCACTCCGCC
AACGTGCTCCACCGAGATCTAAAGCCCTCCAACCTGCTCAGCAACACCACCTGCGACCTT
AAGATTTGTGATTTCGGCCTGGCCCGGATTGCCGATCCTGAGCATGACCACACCGGCTTC
CTGACGGAGTATGTGGCTACGCGCTGGTACCGGGCCCCAGAGATCATGCTGAACTCCAAG
GGCTATACCAAGTCCATCGACATCTGGTCTGTGGGCTGCATTCTGGCTGAGATGCTCTCT
AACCGGCCCATCTTCCCTGGCAAGCACTACCTGGATCAGCTCAACCACATTCTGGGCATC
CTGGGCTCCCCATCCCAGGAGGACCTGAATTGTATCATCAACATGAAGGCCCGAAACTAC
CTACAGTCTCTGCCCTCCAAGACCAAGGTGGCTTGGGCCAAGCTTTTCCCCAAGTCAGAC
TCCAAAGCCCTTGACCTGCTGGACCGGATGTTAACCTTTAACCCCAATAAACGGATCACA
GTGGAGGAAGCGCTGGCTCACCCCTACCTGGAGCAGTACTATGACCCGACGGATGAGCCA
GTGGCCGAGGAGCCCTTCACCTTCGCCATGGAGCTGGATGACCTACCTAAGGAGCGGCTG
AAGGAGCTCATCTTCCAGGAGACAGCACGCTTCCAGCCCGGAGTGCTGGAGGCCCCCTAG


# Macromolecular_Interacting_Partner_15_GenBank_ID_Gene:
X60188

# Macromolecular_Interacting_Partner_15_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_15_Locus:
16p11.2

# Macromolecular_Interacting_Partner_15_SNPs:
rs1143695; rs11865086; rs11864737; rs9921806; rs12922100; rs11863765; rs9930013; rs11546680; rs41292376; rs41291696; rs41280862; rs35691465; rs41280866; rs41280860; rs41280864; rs35666305; rs11644927; rs7199920; rs12918285; rs36084237; rs34799400; rs34564246; rs9940575; rs9940581; rs28529403; rs1042404; rs1062543; rs12924137; rs12930241; rs13569; rs1561414; rs2005219; rs3751867; rs7542; rs7698; rs8061772

# Macromolecular_Interacting_Partner_15_General_References:
7687743; 1540184; 1319925; 8794306

# Macromolecular_Interacting_Partner_15_References:
15608389; 15637466; 15699469; 15761031

# Macromolecular_Interacting_Partner_16_ID:
7645

# Macromolecular_Interacting_Partner_16_Name:
Connective tissue growth factor precursor

# Macromolecular_Interacting_Partner_16_Synonyms:
Hypertrophic chondrocyte- specific protein 24

# Macromolecular_Interacting_Partner_16_Gene_Name:
CTGF

# Macromolecular_Interacting_Partner_16_Protein_Sequence:
>Connective tissue growth factor precursor
MTAASMGPVRVAFVVLLALCSRPAVGQNCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVC
AKQLGELCTERDPCDPHKGLFCHFGSPANRKIGVCTAKDGAPCIFGGTVYRSGESFQSSC
KYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALA
AYRLEDTFGPDPTMIRANCLVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVR
PCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTT
LPVEFKCPDGEVMKKNMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA

# Macromolecular_Interacting_Partner_16_Number_of_Residues:
349

# Macromolecular_Interacting_Partner_16_Molecular_Weight:
38092

# Macromolecular_Interacting_Partner_16_Theoretical_pI:
8.03

# Macromolecular_Interacting_Partner_16_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  growth factor binding
Function:  insulin-like growth factor binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of growth
Process:  regulation of cell growth
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_16_General_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Specific_Function:
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis

# Macromolecular_Interacting_Partner_16_Pathway:
Not Available

# Macromolecular_Interacting_Partner_16_Reaction:
Not Available

# Macromolecular_Interacting_Partner_16_Pfam_Domain_Function:
PF00007:Cys_knot;
PF00219:IGFBP;
PF00090:TSP_1;
PF00093:VWC

# Macromolecular_Interacting_Partner_16_Signals:
1-26

# Macromolecular_Interacting_Partner_16_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_16_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_16_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_16_GenBank_ID_Protein:
180924

# Macromolecular_Interacting_Partner_16_SwissProt_ID:
CTGF_HUMAN (P29279)

# Macromolecular_Interacting_Partner_16_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_16_Genecard_id:
CTGF

# Macromolecular_Interacting_Partner_16_Geneatlas_id:
CTGF

# Macromolecular_Interacting_Partner_16_hgnc_id:
HGNC:2500

# Macromolecular_Interacting_Partner_16_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_16_Subcellular_Location:
Secreted protein; extracellular space; extracellular matrix. Secreted protein (By similarity)

# Macromolecular_Interacting_Partner_16_Gene_Sequence:
>1050 bp
ATGACCGCCGCCAGTATGGGCCCCGTCCGCGTCGCCTTCGTGGTCCTCCTCGCCCTCTGC
AGCCGGCCGGCCGTCGGCCAGAACTGCAGCGGGCCGTGCCGGTGCCCGGACGAGCCGGCG
CCGCGCTGCCCGGCGGGCGTGAGCCTCGTGCTGGACGGCTGCGGCTGCTGCCGCGTCTGC
GCCAAGCAGCTGGGCGAGCTGTGCACCGAGCGCGACCCCTGCGACCCGCACAAGGGCCTC
TTCTGTGACTTCGGCTCCCCGGCCAACCGCAAGATCGGCGTGTGCACCGCCAAAGATGGT
GCTCCCTGCATCTTCGGTGGTACGGTGTACCGCAGCGGAGAGTCCTTCCAGAGCAGCTGC
AAGTACCAGTGCACGTGCCTGGACGGGGCGGTGGGCTGCATGCCCCTGTGCAGCATGGAC
GTTCGTCTGCCCAGCCCTGACTGCCCCTTCCCGAGGAGGGTCAAGCTGCCCGGGAAATGC
TGCGAGGAGTGGGTGTGTGACGAGCCCAAGGACCAAACCGTGGTTGGGCCTGCCCTCGCG
GCTTACCGACTGGAAGACACGTTTGGCCCAGACCCAACTATGATTAGAGCCAACTGCCTG
GTCCAGACCACAGAGTGGAGCGCCTGTTCCAAGACCTGTGGGATGGGCATCTCCACCCGG
GTTACCAATGACAACGCCTCCTGCAGGCTAGAGAAGCAGAGCCGCCTGTGCATGGTCAGG
CCTTGCGAAGCTGACCTGGAAGAGAACATTAAGAAGGGCAAAAAGTGCATCCGTACTCCC
AAAATCTCCAAGCCTATCAAGTTTGAGCTTTCTGGCTGCACCAGCATGAAGACATACCGA
GCTAAATTCTGTGGAGTATGTACCGACGGCCGATGCTGCACCCCCCACAGAACCACCACC
CTGCCGGTGGAGTTCAAGTGCCCTGACGGCGAGGTCATGAAGAAGAACATGATGTTCATC
AAGACCTGTGCCTGCCATTACAACTGTCCCGGAGACAATGACATCTTTGAATCGCTGTAC
TACAGGAAGATGTACGGAGACATGGCATGA

# Macromolecular_Interacting_Partner_16_GenBank_ID_Gene:
M92934

# Macromolecular_Interacting_Partner_16_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_16_Locus:
6q23.1

# Macromolecular_Interacting_Partner_16_SNPs:
Not Available

# Macromolecular_Interacting_Partner_16_General_References:
1654338; 1293144; 9054739; 14574404; 10614647; 12553878

# Macromolecular_Interacting_Partner_16_References:
15608389; 16723984

# Macromolecular_Interacting_Partner_17_ID:
5991

# Macromolecular_Interacting_Partner_17_Name:
Corticosteroid 11-beta-dehydrogenase isozyme 2

# Macromolecular_Interacting_Partner_17_Synonyms:
11-DH2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-beta-HSD2; NAD- dependent 11-beta-hydroxysteroid dehydrogenase

# Macromolecular_Interacting_Partner_17_Gene_Name:
HSD11B2

# Macromolecular_Interacting_Partner_17_Protein_Sequence:
>Corticosteroid 11betadehydrogenase isozyme 2
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV
LAAAGWIALS
RLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSP
GAIELRTCCSPRLRLLQMDLT
KPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAE
LSPVATFRSCMEVNFFGALELTKGLLPLLRSS
RGRIVTVGSPAGDMPYPCLGAYGTSKA
AVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRK
QLLLANLPQELLQAYG
KDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFI
HYYLP
EGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR

# Macromolecular_Interacting_Partner_17_Number_of_Residues:
405

# Macromolecular_Interacting_Partner_17_Molecular_Weight:
44127

# Macromolecular_Interacting_Partner_17_Theoretical_pI:
9.58

# Macromolecular_Interacting_Partner_17_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_17_General_Function:
Lipid transport and metabolism 

# Macromolecular_Interacting_Partner_17_Specific_Function:
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids

# Macromolecular_Interacting_Partner_17_Pathway:
Not Available

# Macromolecular_Interacting_Partner_17_Reaction:
Not Available

# Macromolecular_Interacting_Partner_17_Pfam_Domain_Function:
PF00106:adh_short

# Macromolecular_Interacting_Partner_17_Signals:
1-21

# Macromolecular_Interacting_Partner_17_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_17_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_17_EC_Link:
EC 1.1.1.146

# Macromolecular_Interacting_Partner_17_GenBank_ID_Protein:
565082

# Macromolecular_Interacting_Partner_17_SwissProt_ID:
DHI2_HUMAN (P80365)

# Macromolecular_Interacting_Partner_17_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_17_Genecard_id:
HSD11B2

# Macromolecular_Interacting_Partner_17_Geneatlas_id:
HSD11B2

# Macromolecular_Interacting_Partner_17_hgnc_id:
HGNC:5209

# Macromolecular_Interacting_Partner_17_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_17_Subcellular_Location:
Microsome

# Macromolecular_Interacting_Partner_17_Gene_Sequence:
>1218 bp

ATGGAGCGCTGGCCTTGGCCGTCGGGCGGCGCCTGGCTGCTCGTGGCTGCCCGCGCGCT
GCTGCAGCTGC
TGCGCTCAGACCTGCGTCTGGGCCGCCCGCTGCTGGCGGCGCTGGCGC
TGCTGGCCGCGCTCGACTGGCT
GTGCCAGCGCCTGCTGCCCCCGCCGGCCGCACTCGCC
GTGCTGGCCGCCGCCGGCTGGATCGCGTTGTCC
CGCCTGGCGCGCCCGCAGCGCCTGCC
GGTGGCCACTCGCGCGGTGCTCATCACCGGCTGTGACTCTGGTT
TTGGCAAGGAGACGG
CCAAGAAACTGGACTCCATGGGCTTCACGGTGCTGGCCACCGTATTGGAGTTGAA
CAGC
CCCGGTGCCATCGAGCTGCGTACCTGCTGCTCCCCTCGCCTAAGGCTGCTGCAGATGGAC
CTGACC
AAACCAGGAGACATTAGCCGCTTGCTAGAGTTCACCAAGGCCCACACCACCAG
CACCGGCCTGTGGGGCC
TCGTCAACAACGCAGGCCACAATGAAGTAGTTGCTGATGCGG
AGCTGTCTCCAGTGGCCACTTTCCGTAG
CTGCATGGAGGTGAATTTCTTTGGCGCGCTC
GAGCTGACCAAGGGCCTCCTGCCCCTGCTGCGCAGCTCA
AGGGGCCGCATCGTGACTGT
GGGGAGCCCAGCGGGGGACATGCCATATCCGTGCTTGGGGGCCTATGGAA
CCTCCAAAG
CGGCCGTGGCGCTACTCATGGACACATTCAGCTGTGAACTCCTTCCCTGGGGGGTCAAGG
T
CAGCATCATCCAGCCTGGCTGCTTCAAGACAGAGTCAGTGAGAAACGTGGGTCAGTGG
GAAAAGCGCAAG
CAATTGCTGCTGGCCAACCTGCCTCAAGAGCTGCTGCAGGCCTACGG
CAAGGACTACATCGAGCACTTGC
ATGGGCAGTTCCTGCACTCGCTACGCCTGGCCATGT
CCGACCTCACCCCAGTTGTAGATGCCATCACAGA
TGCGCTGCTGGCAGCTCGGCCCCGC
CGCCGCTATTACCCCGGCCAGGGCCTGGGGCTCATGTACTTCATC
CACTACTACCTGCC
TGAAGGCCTGCGGCGCCGCTTCCTGCAGGCCTTCTTCATCAGTCACTGTCTGCCTC
GAG
CACTGCAGCCTGGCCAGCCTGGCACTACCCCACCACAGGACGCAGCCCAGGACCCAAACC
TGAGCCC
CGGCCCTTCCCCAGCAGTGGCTCGGTGA

# Macromolecular_Interacting_Partner_17_GenBank_ID_Gene:
U14631

# Macromolecular_Interacting_Partner_17_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_17_Locus:
16q22

# Macromolecular_Interacting_Partner_17_SNPs:
rs5479; rs5480; rs9923709; rs13329942; rs17855911; rs28934592; rs28934594; rs13306425; rs17853703; rs28934591; rs28934593; rs1139495; rs2855410; rs5481; rs2549646; rs35257037; rs2855408; rs12935213; rs12919979; rs12934342; rs12934368; rs2549644; rs12935253; rs12919584; rs12934351; rs28464206; rs12933947; rs34076422; rs2549647; rs11413878; rs2549645; rs12934369; rs13306424; rs2855411; rs2855407; rs2549643; rs2549641; rs2855406; rs2911119; rs2855405; rs2549642; rs2925933; rs28373713; rs12918538; rs2911120; rs1053099; rs1053271; rs11860837; rs1213164; rs12596882; rs16957430; rs1802795; rs2279023; rs34389524; rs4360931; rs6499129; rs8056260; rs9922476; rs9922624; rs9936153; rs9936306; rs9940901

# Macromolecular_Interacting_Partner_17_General_References:
7859916; 8530071; 8611140; 11350956; 2889032; 7608290; 7593417; 7670488; 9398712; 9683587; 9661590; 9851783; 9707624; 10489390; 10523339; 11238516

# Macromolecular_Interacting_Partner_17_References:
16109662; 16320254

# Macromolecular_Interacting_Partner_18_ID:
6751

# Macromolecular_Interacting_Partner_18_Name:
Rho-associated protein kinase 1

# Macromolecular_Interacting_Partner_18_Synonyms:
Rho-associated, coiled- coil-containing protein kinase 1; p160 ROCK-1; p160ROCK; Renal carcinoma antigen NY-REN-35

# Macromolecular_Interacting_Partner_18_Gene_Name:
ROCK1

# Macromolecular_Interacting_Partner_18_Protein_Sequence:
>Rhoassociated protein kinase 1
MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK
DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF
FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY
ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP
DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNA
DKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST
VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKL
SQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTD
KDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLN
HSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKL
KEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQES
NKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMR
ELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAE
SEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENE
ELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRK
KANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQL
ASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSVPNRGNIKRYGWKK
QYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILY
ANEGECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALE
CRRCHVKCHRDHLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNP
PSGFVRASPRTLSTRSTANQSFRKVVKNTSGKTS

# Macromolecular_Interacting_Partner_18_Number_of_Residues:
1354

# Macromolecular_Interacting_Partner_18_Molecular_Weight:
158177

# Macromolecular_Interacting_Partner_18_Theoretical_pI:
5.67

# Macromolecular_Interacting_Partner_18_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  cell
Component:  intracellular

# Macromolecular_Interacting_Partner_18_General_Function:
Not Available

# Macromolecular_Interacting_Partner_18_Specific_Function:
Protein kinase that phosphorylates a large number of important signaling proteins, and thereby regulates the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Necessary for apoptotic membrane blebbing. Plays a role in smooth muscle contraction. Required for centromere positioning and centromere- dependent exit from mitosis

# Macromolecular_Interacting_Partner_18_Pathway:
Not Available

# Macromolecular_Interacting_Partner_18_Reaction:
Not Available

# Macromolecular_Interacting_Partner_18_Pfam_Domain_Function:
PF00130:C1_1;
PF02185:HR1;
PF00169:PH;
PF00069:Pkinase;
PF00433:Pkinase_C;
PF08912:Rho_Binding

# Macromolecular_Interacting_Partner_18_Signals:
None

# Macromolecular_Interacting_Partner_18_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_18_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_18_EC_Link:
EC 2.7.11.1

# Macromolecular_Interacting_Partner_18_GenBank_ID_Protein:
1276901

# Macromolecular_Interacting_Partner_18_SwissProt_ID:
ROCK1_HUMAN (Q13464)

# Macromolecular_Interacting_Partner_18_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_18_Genecard_id:
ROCK1

# Macromolecular_Interacting_Partner_18_Geneatlas_id:
ROCK1

# Macromolecular_Interacting_Partner_18_hgnc_id:
HGNC:10251

# Macromolecular_Interacting_Partner_18_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_18_Subcellular_Location:
Cytoplasm. Centrosome; centriole. Golgi apparatus; Golgi apparatus membrane; peripheral membrane protein. Note=Associated with the mother centriole and an intercentriolar linker (By similarity). A small proportion is associated with Golgi membranes

# Macromolecular_Interacting_Partner_18_Gene_Sequence:
>4065 bp
ATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACCTGCTGCGGGAT
CCCAAATCGGAAGTGAATTCGGATTGTTTGCTGGATGGATTGGATGCTTTGGTATATGAT
TTGGATTTTCCTGCCTTAAGAAAAAACAAAAATATTGACAACTTTTTAAGCAGATATAAA
GACACAATAAATAAAATCAGAGATTTACGAATGAAAGCTGAAGATTATGAAGTAGTGAAG
GTGATTGGTAGAGGTGCATTTGGAGAAGTTCAATTGGTAAGGCATAAATCCACCAGGAAG
GTATATGCTATGAAGCTTCTCAGCAAATTTGAAATGATAAAGAGATCTGATTCTGCTTTT
TTCTGGGAAGAAAGGGACATCATGGCTTTTGCCAACAGTCCTTGGGTTGTTCAGCTTTTT
TATGCATTCCAAGATGATCGTTATCTCTACATGGTGATGGAATACATGCCTGGTGGAGAT
CTTGTAAACTTAATGAGCAACTATGATGTGCCTGAAAAATGGGCACGATTCTATACTGCA
GAAGTAGTTCTTGCATTGGATGCAATCCATTCCATGGGTTTTATTCACAGAGATGTGAAG
CCTGATAACATGCTGCTGGATAAATCTGGACATTTGAAGTTAGCAGATTTTGGTACTTGT
ATGAAGATGAATAAGGAAGGCATGGTACGATGTGATACAGCGGTTGGAACACCTGATTAT
ATTTCCCCTGAAGTATTAAAATCCCAAGGTGGTGATGGTTATTATGGAAGAGAATGTGAC
TGGTGGTCGGTTGGGGTATTTTTATACGAAATGCTTGTAGGTGATACACCTTTTTATGCA
GATTCTTTGGTTGGAACTTACAGTAAAATTATGAACCATAAAAATTCACTTACCTTTCCT
GATGATAATGACATATCAAAAGAAGCAAAAAACCTTATTTGTGCCTTCCTTACTGACAGG
GAAGTGAGGTTAGGGCGAAATGGTGTAGAAGAAATCAAACGACATCTCTTCTTCAAAAAT
GACCAGTGGGCTTGGGAAACGCTCCGAGACACTGTAGCACCAGTTGTACCCGATTTAAGT
AGTGACATTGATACTAGTAATTTTGATGACTTGGAAGAAGATAAAGGAGAGGAAGAAACA
TTCCCTATTCCTAAAGCTTTCGTTGGCAATCAACTACCTTTTGTAGGATTTACATATTAT
AGCAATCGTAGATACTTATCTTCAGCAAATCCTAATGATAACAGAACTAGCTCCAATGCA
GATAAAAGCTTGCAGGAAAGTTTGCAAAAAACAATCTATAAGCTGGAAGAACAGCTGCAT
AATGAAATGCAGTTAAAAGATGAAATGGAGCAGAAGTGCAGAACCTCAAACATAAAACTA
GACAAGATAATGAAAGAATTGGATGAAGAGGGAAATCAAAGAAGAAATCTAGAATCTACA
GTGTCTCAGATTGAGAAGGAGAAAATGTTGCTACAGCATAGAATTAATGAGTACCAAAGA
AAAGCTGAACAGGAAAATGAGAAGAGAAGAAATGTAGAAAATGAAGTTTCTACATTAAAG
GATCAGTTGGAAGACTTAAAGAAAGTCAGTCAGAATTCACAGCTTGCTAATGAGAAGCTG
TCCCAGTTACAAAAGCAGCTAGAAGAAGCCAATGACTTACTTAGGACAGAATCGGACACA
GCTGTAAGATTGAGGAAGAGTCACACAGAGATGAGCAAGTCAATTAGTCAGTTAGAGTCC
CTGAACAGAGAGTTGCAAGAGAGAAATCGAATTTTAGAGAATTCTAAGTCACAAACAGAC
AAAGATTATTACCAGCTGCAAGCTATATTAGAAGCTGAACGAAGAGACAGAGGTCATGAT
TCTGAGATGATTGGAGACCTTCAAGCTCGAATTACATCTTTACAAGAGGAGGTGAAGCAT
CTCAAACATAATCTCGAAAAAGTGGAAGGAGAAAGAAAAGAGGCTCAAGACATGCTTAAT
CACTCAGAAAAGGAAAAGAATAATTTAGAGATAGATTTAAACTACAAACTTAAATCATTA
CAACAACGGTTAGAACAAGAGGTAAATGAACACAAAGTAACCAAAGCTCGTTTAACTGAC
AAACATCAATCTATTGAAGAGGCAAAGTCTGTGGCAATGTGTGAGATGGAAAAAAAGCTG
AAAGAAGAAAGAGAAGCTCGAGAGAAGGCTGAAAATCGGGTTGTTCAGATTGAGAAACAG
TGTTCCATGCTAGACGTTGATCTGAAGCAATCTCAGCAGAAACTAGAACATTTGACTGGA
AATAAAGAAAGGATGGAGGATGAAGTTAAGAATCTAACCCTGCAACTGGAGCAGGAATCA
AATAAGCGGCTGTTGTTACAAAATGAATTGAAGACTCAAGCATTTGAGGCAGACAATTTA
AAAGGTTTAGAAAAGCAGATGAAACAGGAAATAAATACTTTATTGGAAGCAAAGAGATTA
TTAGAATTTGAGTTAGCTCAGCTTACGAAACAGTATAGAGGAAATGAAGGACAGATGCGG
GAGCTACAAGATCAGCTTGAAGCTGAGCAATATTTCTCGACACTTTATAAAACCCAGGTA
AAGGAACTTAAAGAAGAAATTGAAGAAAAAAACAGAGAAAATTTAAAGAAAATACAGGAA
CTACAAAATGAAAAAGAAACTCTTGCTACTCAGTTGGATCTAGCAGAAACAAAAGCTGAG
TCTGAGCAGTTGGCGCGAGGCCTTCTGGAAGAACAGTATTTTGAATTGACGCAAGAAAGC
AAGAAAGCTGCTTCAAGAAATAGACAAGAGATTACAGATAAAGATCACACTGTTAGTCGG
CTTGAAGAAGCAAACAGCATGCTAACCAAAGATATTGAAATATTAAGAAGAGAGAATGAA
GAGCTAACAGAGAAAATGAAGAAGGCAGAGGAAGAATATAAACTGGAGAAGGAGGAGGAG
ATCAGTAATCTTAAGGCTGCCTTTGAAAAGAATATCAACACTGAACGAACCCTTAAAACA
CAGGCTGTTAACAAATTGGCAGAAATAATGAATCGAAAAGATTTTAAAATTGATAGAAAG
AAAGCTAATACACAAGATTTGAGAAAGAAAGAAAAGGAAAATCGAAAGCTGCAACTGGAA
CTCAACCAAGAAAGAGAGAAATTCAACCAGATGGTAGTGAAACATCAGAAGGAACTGAAT
GACATGCAAGCGCAATTGGTAGAAGAATGTGCACATAGGAATGAGCTTCAGATGCAGTTG
GCCAGCAAAGAGAGTGATATTGAGCAATTGCGTGCTAAACTTTTGGACCTCTCGGATTCT
ACAAGTGTTGCTAGTTTTCCTAGTGCTGATGAAACTGATGGTAACCTCCCAGAGTCAAGA
ATTGAAGGTTGGCTTTCAGTACCAAATAGAGGAAATATCAAACGATATGGCTGGAAGAAA
CAGTATGTTGTGGTAAGCAGCAAAAAAATTTTGTTCTATAATGACGAACAAGATAAGGAG
CAATCCAATCCATCTATGGTATTGGACATAGATAAACTGTTTCACGTTAGACCTGTAACC
CAAGGAGATGTGTATAGAGCTGAAACTGAAGAAATTCCTAAAATATTCCAGATACTATAT
GCAAATGAAGGTGAATGTAGAAAAGATGTAGAGATGGAACCAGTACAACAAGCTGAAAAA
ACTAATTTCCAAAATCACAAAGGCCATGAGTTTATTCCTACACTCTACCACTTTCCTGCC
AATTGTGATGCCTGTGCCAAACCTCTCTGGCATGTTTTTAAGCCACCCCCTGCCCTAGAG
TGTCGAAGATGCCATGTTAAGTGCCACAGAGATCACTTAGATAAGAAAGAGGACTTAATT
TGTCCATGTAAAGTAAGTTATGATGTAACATCAGCAAGAGATATGCTGCTGTTAGCATGT
TCTCAGGATGAACAAAAAAAATGGGTAACTCATTTAGTAAAGAAAATCCCTAAGAATCCA
CCATCTGGTTTTGTTCGTGCTTCCCCTCGAACGCTTTCTACAAGATCCACTGCAAATCAG
TCTTTCCGGAAAGTGGTCAAAAATACATCTGGAAAAACTAGTTAA

# Macromolecular_Interacting_Partner_18_GenBank_ID_Gene:
U43195

# Macromolecular_Interacting_Partner_18_Chromosome_Location:
Chromosome:18

# Macromolecular_Interacting_Partner_18_Locus:
18q11.1

# Macromolecular_Interacting_Partner_18_SNPs:
rs1045142; rs1481280; rs6507132; rs8089751; rs394715; rs431765; rs7244299; rs4800118; rs8094619; rs288980; rs1006881; rs7240577; rs2018403; rs7242932; rs7228948; rs720109; rs288985; rs7239317; rs7237677; rs4800119; rs4800367; rs2219950; rs7244278; rs7238386; rs8096762; rs8090088; rs8085654; rs1552110; rs10775457; rs288979; rs288990; rs11876799; rs167029; rs9966660; rs9949153; rs11873648; rs4800112; rs11877741; rs288981; rs1842609; rs4284728; rs11877273; rs17202361; rs17202375; rs6507131; rs9947681; rs17202347; rs2127958; rs11876032; rs7228804; rs9946327; rs8083275; rs9963775; rs9946941; rs8089184; rs9946192; rs9948357; rs16945468; rs10084016; rs7234943; rs12957846; rs8092199; rs9959590; rs8084725; rs12963497; rs8083580; rs8086381; rs4800803; rs288991; rs7407164; rs9952792; rs11876153; rs9950940; rs12454435; rs4095320; rs167030; rs9953703; rs9959737; rs2170343; rs16964623; rs7237099; rs10221433; rs8085504; rs9957177; rs288989; rs412957; rs16945048; rs288982; rs9955908; rs9953184; rs12458373; rs11665272; rs10164253; rs8097942; rs7231120; rs9965597; rs10853665; rs7227454; rs17202368; rs2136423; rs12956671; rs8085986; rs10221439; rs4800927; rs7241868; rs433301; rs16941481; rs9962144; rs9957055; rs427009; rs2663695; rs288986; rs288983; rs11874761; rs6507467; rs3810041; rs13381022; rs35810558; rs2292296; rs35881519; rs2271255; rs2663698; rs16977695; rs10221369; rs34420242; rs35502945; rs12961735; rs35839101; rs35571240; rs34259251; rs34513739; rs34919797; rs35989724; rs11663442; rs28542979; rs12958389; rs28712007; rs288984; rs3907851; rs377629; rs34307576; rs430919; rs28783679; rs2663692; rs188286; rs35993531; rs35231243; rs35001699; rs10594886; rs34205037; rs35541933; rs34539787; rs413304; rs2663699; rs7234154; rs34360056; rs35084641; rs35742013; rs7236166; rs35818888; rs10696723; rs7233330; rs34771086; rs35982785; rs288987; rs182315; rs34374162; rs28688499; rs34724806; rs35680498; rs28460186; rs9951807; rs35559179; rs35918484; rs36022881; rs34175330; rs10699060; rs35635723; rs28596492; rs33983077; rs9964200; rs2663696; rs34526425; rs35120121; rs1552111; rs34855015; rs34525612; rs409223; rs35308483; rs3914052; rs34260822; rs35127623; rs3907852; rs34950642; rs35852910; rs4007699; rs34517512; rs184087; rs191748; rs35477732; rs35101122; rs11876588; rs34530098; rs34422397; rs36048437; rs9945231; rs34217637; rs28805324; rs34178945; rs28554172; rs7228360; rs35855149; rs2663693; rs34675169; rs9966300; rs11334095; rs35799573; rs7231242; rs35473579; rs10552765; rs35778842; rs9955366; rs34128110; rs35069391; rs35371044; rs34251484; rs34153516; rs10468929; rs34394368; rs9962182; rs35484011; rs11420525; rs7233027; rs12955676; rs35843639; rs34825611; rs190836; rs288988; rs9956016; rs12959966; rs9954965; rs34237874; rs28628243; rs35017267; rs34391179; rs34550208; rs28401685; rs8099337; rs34978965; rs34360889; rs185970; rs176396; rs11367017; rs1552112; rs36028960; rs35585248; rs35633449; rs12957585; rs28532370; rs34203914; rs3838904; rs11344426; rs34574242; rs34734770; rs3914053; rs28656187; rs190837; rs34853602; rs12971060; rs34759565; rs11434159; rs35172134; rs35293147; rs16974954; rs34458918; rs8091263; rs34189792; rs7240394; rs35631259; rs35884206; rs8086115; rs34970736; rs35180891; rs35738276; rs12954030; rs33938715; rs35077728; rs34292703; rs36076192; rs36112524; rs34942095; rs420980; rs7243358; rs35353434; rs34934193; rs4414579; rs34310042; rs192624; rs5823294; rs8094951; rs7243774; rs16978270; rs34108991; rs10718814; rs10708353; rs35403307; rs28709741; rs8090829; rs35443203; rs176397; rs34885138; rs8098729; rs35294556; rs35565387; rs34217716; rs12969280; rs188287; rs12955714; rs34945520; rs3907850; rs3914054; rs34641736; rs9955452; rs11387860; rs2663703; rs4007700; rs34499105; rs2663702; rs7237731; rs2663701; rs28667053; rs28536090; rs35996865; rs12607616; rs1275227; rs2555396; rs373153; rs398528

# Macromolecular_Interacting_Partner_18_General_References:
8617235; 10508479; 11283607; 12773565

# Macromolecular_Interacting_Partner_18_References:
16555582

# Macromolecular_Interacting_Partner_19_ID:
7803

# Macromolecular_Interacting_Partner_19_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_19_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_19_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_19_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_19_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_19_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_19_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_19_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_19_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_19_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_19_Pathway:
Not Available

# Macromolecular_Interacting_Partner_19_Reaction:
Not Available

# Macromolecular_Interacting_Partner_19_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_19_Signals:
None

# Macromolecular_Interacting_Partner_19_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_19_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_19_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_19_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_19_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_19_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_19_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_19_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_19_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_19_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_19_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_19_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_19_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_19_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_19_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_19_SNPs:
Not Available

# Macromolecular_Interacting_Partner_19_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_19_References:
15872074; 16633090

# Macromolecular_Interacting_Partner_20_ID:
8108

# Macromolecular_Interacting_Partner_20_Name:
Angiotensinogen precursor

# Macromolecular_Interacting_Partner_20_Synonyms:
Serpin A8[Contains: Angiotensin-1; Angiotensin I; Ang I; Angiotensin-2; Angiotensin II; Ang II; Angiotensin-3; Angiotensin III; Ang III; Des-Asp[1]-angiotensin II]

# Macromolecular_Interacting_Partner_20_Gene_Name:
AGT

# Macromolecular_Interacting_Partner_20_Protein_Sequence:
>Angiotensinogen precursor
MRKRAPQSEMAPAGVSLRATILCLLAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAG
KPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGM
HSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKV
LSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLD
FTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEF
WVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLT
FQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIR
VGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVAN
PLSTA

# Macromolecular_Interacting_Partner_20_Number_of_Residues:
485

# Macromolecular_Interacting_Partner_20_Molecular_Weight:
53155

# Macromolecular_Interacting_Partner_20_Theoretical_pI:
6.27

# Macromolecular_Interacting_Partner_20_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  protease inhibitor activity
Function:  endopeptidase inhibitor activity
Function:  serine-type endopeptidase inhibitor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_20_General_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Specific_Function:
Angiotensin-3 stimulates aldosterone release

# Macromolecular_Interacting_Partner_20_Pathway:
Not Available

# Macromolecular_Interacting_Partner_20_Reaction:
Not Available

# Macromolecular_Interacting_Partner_20_Pfam_Domain_Function:
PF00079:Serpin

# Macromolecular_Interacting_Partner_20_Signals:
1-33

# Macromolecular_Interacting_Partner_20_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_20_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_20_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_20_GenBank_ID_Protein:
178640

# Macromolecular_Interacting_Partner_20_SwissProt_ID:
ANGT_HUMAN (P01019)

# Macromolecular_Interacting_Partner_20_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_20_Genecard_id:
AGT

# Macromolecular_Interacting_Partner_20_Geneatlas_id:
AGT

# Macromolecular_Interacting_Partner_20_hgnc_id:
HGNC:333

# Macromolecular_Interacting_Partner_20_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_20_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_20_Gene_Sequence:
>1458 bp
ATGCGGAAGCGAGCACCCCAGTCTGAGATGGCTCCTGCCGGTGTGAGCCTGAGGGCCACC
ATCCTCTGCCTCCTGGCCTGGGCTGGCCTGGCTGCAGGTGACCGGGTGTACATACACCCC
TTCCACCTCGTCATCCACAATGAGAGTACCTGTGAGCAGCTGGCAAAGGCCAATGCCGGG
AAGCCCAAAGACCCCACCTTCATACCTGCTCCAATTCAGGCCAAGACATCCCCTGTGGAT
GAAAAGGCCCTACAGGACCAGCTGGTGCTAGTCGCTGCAAAACTTGACACCGAAGACAAG
TTGAGGGCCGCAATGGTCGGGATGCTGGCCAACTTCTTGGGCTTCCGTATATATGGCATG
CACAGTGAGCTATGGGGCGTGGTCCATGGGGCCACCGTCCTCTCCCCAACGGCTGTCTTT
GGCACCCTGGCCTCTCTCTATCTGGGAGCCTTGGACCACACAGCTGACAGGCTACAGGCA
ATCCTGGGTGTTCCTTGGAAGGACAAGAACTGCACCTCCCGGCTGGATGCGCACAAGGTC
CTGTCTGCCCTGCAGGCTGTACAGGGCCTGCTAGTGGCCCAGGGCAGGGCTGATAGCCAG
GCCCAGCTGCTGCTGTCCACGGTGGTGGGCGTGTTCACAGCCCCAGGCCTGCACCTGAAG
CAGCCGTTTGTGCAGGGCCTGGCTCTCTATACCCCTGTGGTCCTCCCACGCTCTCTGGAC
TTCACAGAACTGGATGTTGCTGCTGAGAAGATTGACAGGTTCATGCAGGCTGTGACAGGA
TGGAAGACTGGCTGCTCCCTGATGGGAGCCAGTGTGGACAGCACCCTGGCTTTCAACACC
TACGTCCACTTCCAAGGGAAGATGAAGGGCTTCTCCCTGCTGGCCGAGCCCCAGGAGTTC
TGGGTGGACAACAGCACCTCAGTGTCTGTTCCCATGCTCTCTGGCATGGGCACCTTCCAG
CACTGGAGTGACATCCAGGACAACTTCTCGGTGACTCAAGTGCCCTTCACTGAGAGCGCC
TGCCTGCTGCTGATCCAGCCTCACTATGCCTCTGACCTGGACAAGGTGGAGGGTCTCACT
TTCCAGCAAAACTCCCTCAACTGGATGAAGAAACTGTCTCCCCGGACCATCCACCTGACC
ATGCCCCAACTGGTGCTGCAAGGATCTTATGACCTGCAGGACCTGCTCGCCCAGGCTGAG
CTGCCCGCCATTCTGCACACCGAGCTGAACCTGCAAAAATTGAGCAATGACCGCATCAGG
GTGGGGGAGGTGCTGAACAGCATTTTTTTTGAGCTTGAAGCGGATGAGAGAGAGCCCACA
GAGTCTACCCAACAGCTTAACAAGCCTGAGGTCTTGGAGGTGACCCTGAACCGCCCATTC
CTGTTTGCTGTGTATGATCAAAGCGCCACTGCCCTGCACTTCCTGGGCCGCGTGGCCAAC
CCGCTGAGCACAGCATGA

# Macromolecular_Interacting_Partner_20_GenBank_ID_Gene:
K02215

# Macromolecular_Interacting_Partner_20_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_20_Locus:
1q42-q43

# Macromolecular_Interacting_Partner_20_SNPs:
rs11568032; rs699; rs11568053; rs34829218; rs4762; rs11568041; rs2478522; rs5040; rs11568052; rs2004776; rs3789679; rs7539020; rs3789678; rs11568028; rs11568050; rs2493134; rs3889728; rs11568051; rs1078499; rs11568025; rs11568022; rs7539013; rs2148582; rs11568024; rs3827750; rs11568023; rs11568026; rs11122576; rs5050; rs5044; rs11568021; rs11568027; rs11568049; rs11568029; rs11122578; rs11568030; rs5051; rs4753; rs11122577; rs11568031; rs5043; rs5042; rs913147; rs1326883; rs5052; rs7079; rs2478539; rs2493132; rs2493129; rs3789671; rs1926722; rs11568055; rs10864772; rs11568044; rs3789669; rs11568036; rs11568034; rs3789664; rs11568040; rs3789666; rs11568045; rs2478543; rs2478545; rs6687360; rs1926723; rs2493133; rs11568039; rs2478544; rs2493131; rs11122575; rs11568054; rs3827749; rs11568056; rs2493130; rs3789677; rs11568038; rs11568042; rs2478523; rs11568035; rs11568037; rs3789670; rs3789667; rs11568043; rs3789672; rs11568033; rs7543316; rs10864771; rs10864770; rs943580; rs11568048; rs11568014; rs5046; rs6683321; rs7536290; rs2071404; rs5049; rs2067853; rs11568057; rs11568019; rs11568016; rs11122580; rs11122574; rs11568015; rs943581; rs2071406; rs2071405; rs2493136; rs11568018; rs11122573; rs5045; rs11568046; rs5048; rs2478524; rs5047; rs2493135; rs16852352; rs11568017; rs11568020; rs7533803; rs5039; rs1805090; rs5041; rs11557882; rs13306155; rs11557881; rs1803105; rs2229389; rs11557883; rs41271499; rs17856352; rs11557884; rs11557886; rs11557885; rs4029126; rs1803106; rs1803104; rs34099195; rs15022; rs1800585; rs1045464; rs11684; rs35680836; rs1803103; rs35832019; rs28730748; rs34041147; rs34069211; rs35937843; rs12125552; rs13306154; rs3789665; rs35832452; rs34924695; rs34433365; rs36218431; rs10545629; rs10593363; rs34758442; rs5781599; rs11445360; rs34933000; rs36218766; rs1051038; rs10864769; rs10864773; rs12042687; rs12059975; rs12083907; rs12723373; rs12746025; rs1326885; rs1326886; rs1410142; rs1410144; rs1854053; rs2296801; rs2478534; rs2493125; rs2493127; rs2493137; rs3789657; rs3789662; rs4028824; rs4284270; rs4628514; rs4846866; rs7524283; rs7549009; rs7555650; rs9804147

# Macromolecular_Interacting_Partner_20_General_References:
6089875; 2924688; 1692023; 2885106; 3579322; 7259779; 7539791; 4300938; 3934016; 1132082; 9492317; 1394429; 8513325; 7607642; 7744780; 8621667

# Macromolecular_Interacting_Partner_20_References:
15344688; 15492573; 15523303; 15526241

# Macromolecular_Interacting_Partner_21_ID:
8444

# Macromolecular_Interacting_Partner_21_Name:
Transforming growth factor beta-1 precursor

# Macromolecular_Interacting_Partner_21_Synonyms:
TGF-beta-1[Contains: Latency-associated peptide; LAP]

# Macromolecular_Interacting_Partner_21_Gene_Name:
TGFB1

# Macromolecular_Interacting_Partner_21_Protein_Sequence:
>Transforming growth factor beta1 precursor
MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI
YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR
YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT
TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI
DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA
LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

# Macromolecular_Interacting_Partner_21_Number_of_Residues:
390

# Macromolecular_Interacting_Partner_21_Molecular_Weight:
44342

# Macromolecular_Interacting_Partner_21_Theoretical_pI:
8.63

# Macromolecular_Interacting_Partner_21_GO_Classification:
>>>
Function:  growth factor activity
Function:  signal transducer activity
Function:  receptor binding
Function:  transforming growth factor beta receptor binding
 ||
>>>
Process:  growth
Process:  cell growth
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_21_General_Function:
Not Available

# Macromolecular_Interacting_Partner_21_Specific_Function:
Multifunctional protein that control proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGFB1 and essentially all of them have specific receptors for this protein. It regulates the actions of many other growth factors and determines a positive or negative direction of their effects. It plays an important role in bone remodelling. It is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts

# Macromolecular_Interacting_Partner_21_Pathway:
Not Available

# Macromolecular_Interacting_Partner_21_Reaction:
Not Available

# Macromolecular_Interacting_Partner_21_Pfam_Domain_Function:
PF00019:TGF_beta;
PF00688:TGFb_propeptide

# Macromolecular_Interacting_Partner_21_Signals:
1-29

# Macromolecular_Interacting_Partner_21_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_21_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_21_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_21_GenBank_ID_Protein:
1212989

# Macromolecular_Interacting_Partner_21_SwissProt_ID:
TGFB1_HUMAN (P01137)

# Macromolecular_Interacting_Partner_21_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_21_Genecard_id:
TGFB1

# Macromolecular_Interacting_Partner_21_Geneatlas_id:
TGFB1

# Macromolecular_Interacting_Partner_21_hgnc_id:
HGNC:11766

# Macromolecular_Interacting_Partner_21_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_21_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_21_Gene_Sequence:
>355 bp
ATGCCGCCCTCCGGGCTGCGGCTGCTGCTGCTGCTGCTACCGCTGCTGTGGCTACTGGTG
CTGACGCCTGGCCGGCCGGCCGCGGGACTATCCACCTGCAAGACTATCGACATGGAGCTG
GTGAAGCGGAAGCGCATCGAGGCCATCCGCGGCCAGATCCTGTCCAAGCTGCGGCTCGCC
AGCCCCCCGAGCCAGGGGGAGGTGCCGCCCGGCCCGCTGCCCGAGGCCGTGCTCGCCCTG
TACAACAGCACCCGCGACCGGGTGGCCGGGGAGAGTGCAGAACCGGAGCCCGAGCCTGAG
GCCGACTACTACGCCAAGGAGGTCACCCGCGTGCTAATGGTGGAAACCCACAACG

# Macromolecular_Interacting_Partner_21_GenBank_ID_Gene:
X05839

# Macromolecular_Interacting_Partner_21_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_21_Locus:
19q13.2|19q13.1

# Macromolecular_Interacting_Partner_21_SNPs:
rs1982073; rs1800472; rs1800471; rs9282871; rs11466316; rs11466315; rs2241717; rs7408955; rs2278422; rs13306709; rs7258445; rs2288873; rs747857; rs8110090; rs11466329; rs2288874; rs11466347; rs2241716; rs8179181; rs8102501; rs11466345; rs8105161; rs6508976; rs4803455; rs1989457; rs11466338; rs10405403; rs8108052; rs2241715; rs11466335; rs11466357; rs12461895; rs6508975; rs11466337; rs11466351; rs11466344; rs12462166; rs11466331; rs11466341; rs11466324; rs11466359; rs11466318; rs10420084; rs11466356; rs11466343; rs11466321; rs1549934; rs10406816; rs11466334; rs11466349; rs10416269; rs11466353; rs8179182; rs13447341; rs35383147; rs11466358; rs11551225; rs11551223; rs12977601; rs12985978; rs13306707; rs11551226; rs36102838; rs13306706; rs35025994; rs12977628; rs13306708; rs11466354; rs11466330; rs7249191; rs35169655; rs11466327; rs11466355; rs8102918; rs9749548; rs12983775; rs5828100; rs3061187; rs41275752; rs12979815; rs35276753; rs35019416; rs3061188; rs2288875; rs3061192; rs5828102; rs28730295; rs12976890; rs35312206; rs11466333; rs33950017; rs11403932; rs11466340; rs11331966; rs3061190; rs2014015; rs11466328; rs11672143; rs35976994; rs5828101; rs11466346; rs10418010; rs8108632; rs35676663; rs35197353; rs11466352; rs11307639; rs11347492; rs12980944; rs11367425; rs36050346; rs34368921; rs8103575; rs11466350; rs11466342; rs12978333; rs11466320; rs11466348; rs41333448; rs34971127; rs11673275; rs11466336; rs28769597; rs11466339; rs5828099; rs10406316; rs12976219; rs34233206; rs10417924; rs1054797; rs11083616; rs11304; rs11668109; rs11668308; rs11669342; rs11879777; rs12980298; rs12980942; rs12981053; rs12983047; rs16959007; rs1800468; rs1800469; rs1800820; rs1982072; rs2241712; rs2241713; rs2241714; rs2241718; rs2241719; rs2241720; rs34088631; rs35135271; rs3810173; rs4803454; rs6957; rs7257310; rs7257742

# Macromolecular_Interacting_Partner_21_General_References:
3470709; 3861940; 8471846; 2982829; 3162913; 9150447; 11746498; 8424942; 8424943; 8679613; 9783545; 10973241; 11062463; 12202987; 12493741; 12843182

# Macromolecular_Interacting_Partner_21_References:
16524053; 16790507

# Macromolecular_Interacting_Partner_22_ID:
8193

# Macromolecular_Interacting_Partner_22_Name:
Atrial natriuretic factor precursor

# Macromolecular_Interacting_Partner_22_Synonyms:
ANF; Atrial natriuretic peptide; ANP; Prepronatriodilatin; CDD-ANF[Contains: Cardiodilatin-related peptide; CDP]

# Macromolecular_Interacting_Partner_22_Gene_Name:
NPPA

# Macromolecular_Interacting_Partner_22_Protein_Sequence:
>Atrial natriuretic factor precursor
MSSFSTTTVSFLLLLAFQLLGQTRANPMYNAVSNADLMDFKNLLDHLEEKMPLEDEVVPP
QVLSEPNEEAGAALSPLPEVPPWTGEVSPAQRDGGALGRGPWDSSDRSALLKSKLRALLT
APRSLRRSSCFGGRMDRIGAQSGLGCNSFRYRR

# Macromolecular_Interacting_Partner_22_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_22_Molecular_Weight:
16708

# Macromolecular_Interacting_Partner_22_Theoretical_pI:
7.27

# Macromolecular_Interacting_Partner_22_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_22_General_Function:
Not Available

# Macromolecular_Interacting_Partner_22_Specific_Function:
A potent vasoactive substance which is thought to play a key role in cardiovascular homeostasis. Has a cGMP-stimulating activity

# Macromolecular_Interacting_Partner_22_Pathway:
Not Available

# Macromolecular_Interacting_Partner_22_Reaction:
Not Available

# Macromolecular_Interacting_Partner_22_Pfam_Domain_Function:
PF00212:ANP

# Macromolecular_Interacting_Partner_22_Signals:
1-25

# Macromolecular_Interacting_Partner_22_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_22_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_22_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_22_GenBank_ID_Protein:
178630

# Macromolecular_Interacting_Partner_22_SwissProt_ID:
ANF_HUMAN (P01160)

# Macromolecular_Interacting_Partner_22_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_22_Genecard_id:
NPPA

# Macromolecular_Interacting_Partner_22_Geneatlas_id:
NPPA

# Macromolecular_Interacting_Partner_22_hgnc_id:
HGNC:7939

# Macromolecular_Interacting_Partner_22_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_22_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_22_Gene_Sequence:
>456 bp
ATGAGCTCCTTCTCCACCACCACCGTGAGCTTCCTCCTTTTACTGGCATTCCAGCTCCTA
GGTCAGACCAGAGCTAATCCCATGTACAATGCCGTGTCCAACGCAGACCTGATGGATTTC
AAGAATTTGCTGGACCATTTGGAAGAAAAGATGCCTTTAGAAGATGAGGTCGTGCCCCCA
CAAGTGCTCAGTGAGCCGAATGAAGAAGCGGGGGCTGCTCTCAGCCCCCTCCCTGAGGTG
CCTCCCTGGACCGGGGAAGTCAGCCCAGCCCAGAGAGATGGAGGTGCCCTCGGGCGGGGC
CCCTGGGACTCCTCTGATCGATCTGCCCTCCTAAAAAGCAAGCTGAGGGCGCTGCTCACT
GCCCCTCGGAGCCTGCGGAGATCCAGCTGCTTCGGGGGCAGGATGGACAGGATTGGAGCC
CAGAGCGGACTGGGCTGTAACAGCTTCCGGTACTGA

# Macromolecular_Interacting_Partner_22_GenBank_ID_Gene:
K02043

# Macromolecular_Interacting_Partner_22_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_22_Locus:
1p36.21

# Macromolecular_Interacting_Partner_22_SNPs:
rs5063; rs5065; rs5067; rs5066; rs5068; rs5064; rs198368; rs198367; rs198365; rs198369; rs198366; rs12744433; rs198364; rs198359; rs198358; rs17376426; rs198361; rs198357; rs7552330; rs198372; rs198360; rs198373; rs13305986; rs1803268; rs13305987; rs3170926; rs12565; rs1049827; rs11121835; rs198370; rs12744757; rs35427399; rs41300100; rs12723768; rs41275508; rs41307784; rs6695740; rs35183869; rs5772478; rs17037488; rs1003632; rs12024265; rs1023252; rs11802855; rs12029160; rs12047640; rs12091159; rs12567204; rs14078; rs169158; rs171983; rs17350396; rs198375; rs198381; rs198387; rs198388; rs198402; rs198403; rs198404; rs198405; rs198406; rs198408; rs198409; rs198410; rs198411; rs198412; rs198413; rs198414; rs198415; rs2075538; rs2075539; rs2272802; rs2272803; rs632793; rs6541007; rs6668352; rs6694164; rs7412854

# Macromolecular_Interacting_Partner_22_General_References:
6203042; 6547996; 6095118; 6095119; 6542248; 3158606; 6097248; 6238331; 6230082; 1826098; 8043577

# Macromolecular_Interacting_Partner_22_References:
16212963; 16298263; 16533503

# Macromolecular_Interacting_Partner_23_ID:
8137

# Macromolecular_Interacting_Partner_23_Name:
Mineralocorticoid receptor

# Macromolecular_Interacting_Partner_23_Synonyms:
MR

# Macromolecular_Interacting_Partner_23_Gene_Name:
NR3C2

# Macromolecular_Interacting_Partner_23_Protein_Sequence:
>Mineralocorticoid receptor
METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST
QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE
QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAI
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN
AENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP
ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD
SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF
DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR
DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS
KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL
QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN
TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV
VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML
VEIISDQLPKVESGNAKPLYFHRK

# Macromolecular_Interacting_Partner_23_Number_of_Residues:
984

# Macromolecular_Interacting_Partner_23_Molecular_Weight:
107068

# Macromolecular_Interacting_Partner_23_Theoretical_pI:
7.42

# Macromolecular_Interacting_Partner_23_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_23_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_23_Specific_Function:
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels

# Macromolecular_Interacting_Partner_23_Pathway:
Not Available

# Macromolecular_Interacting_Partner_23_Reaction:
Not Available

# Macromolecular_Interacting_Partner_23_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_23_Signals:
None

# Macromolecular_Interacting_Partner_23_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_23_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_23_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_23_GenBank_ID_Protein:
307166

# Macromolecular_Interacting_Partner_23_SwissProt_ID:
MCR_HUMAN (P08235)

# Macromolecular_Interacting_Partner_23_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_23_Genecard_id:
NR3C2

# Macromolecular_Interacting_Partner_23_Geneatlas_id:
NR3C2

# Macromolecular_Interacting_Partner_23_hgnc_id:
HGNC:7979

# Macromolecular_Interacting_Partner_23_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_23_Subcellular_Location:
Cytoplasm. Nucleus. Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane

# Macromolecular_Interacting_Partner_23_Gene_Sequence:
>2955 bp
ATGGAGACCAAAGGCTACCACAGTCTCCCTGAAGGTCTAGATATGGAAAGACGGTGGGGT
CAAGTTTCTCAGGCTGTGGAGCGTTCTTCCCTGGGACCTACAGAGAGGACCGATGAGAAT
AACTACATGGAGATTGTCAACGTAAGCTGTGTTTCCGGTGCTATTCCAAACAACAGTACT
CAAGGAAGCAGCAAAGAAAAACAAGAACTACTCCCTTGCCTTCAGCAAGACAATAATCGG
CCTGGGATTTTAACATCTGATATTAAAACTGAGCTGGAATCTAAGGAACTTTCAGCAACT
GTAGCTGAGTCCATGGGTTTATATATGGATTCTGTAAGAGATGCTGACTATTCCTATGAG
CAGCAGAACCAACAAGGAAGCATGAGTCCAGCTAAGATTTATCAGAATGTTGAACAGCTG
GTGAAATTTTACAAAGGAAATGGCCATCGTCCTTCCACTCTAAGTTGTGTGAACACGCCC
TTGAGATCATTTATGTCTGACTCTGGGAGCTCCGTGAATGGTGGCGTCATGCGCGCCATT
GTTAAAAGCCCTATCATGTGTCATGAGAAAAGCCCGTCTGTTTGCAGCCCTCTGAACATG
ACATCTTCGGTTTGCAGCCCTGCTGGAATCAACTCTGTGTCCTCCACCACAGCCAGCTTT
GGCAGTTTTCCAGTGCACAGCCCAATCACCCAGGGAACTCCTCTGACATGCTCCCCTAAT
GCTGAAAATCGAGGCTCCAGGTCGCACAGCCCTGCACATGCTAGCAATGTGGGCTCTCCT
CTCTCAAGTCCGTTAAGTAGCATGAAATCCTCAATTTCCAGCCCTCCAAGTCACTGCAGT
GTAAAATCTCCAGTCTCCAGTCCCAATAATGTCACTCTGAGATCCTCTGTGTCTAGCCCT
GCAAATATTAACAACTCAAGGTGCTCTGTTTCCAGCCCTTCGAACACTAATAACAGATCC
ACGCTTTCCAGTCCGGCAGCCAGTACTGTGGGATCTATCTGTAGCCCTGTAAACAATGCC
TTCAGCTACACTGCTTCTGGCACCTCTGCTGGATCCAGTACATTGCGGGATGTGGTTCCC
AGTCCAGACACGCAGGAGAAAGGTGCTCAAGAGGTCCCTTTTCCTAAGACTGAGGAAGTA
GAGAGTGCCATCTCAAATGGTGTGACTGGCCAGCTTAATATTGTCCAGTACATAAAACCA
GAACCAGATGGAGCTTTTAGCAGCTCATGTCTAGGAGGAAATAGCAAAATAAATTCGGAT
TCTTCATTCTCAGTACCAATAAAGCAAGAATCAACCAAGCATTCATGTTCAGGCACCTCT
TTTAAAGGGAATCCAACAGTAAACCCGTTTCCATTTATGGATGGCTCGTATTTTTCCTTT
ATGGATGATAAAGACTATTATTCCCTATCAGGAATTTTAGGACCACCTGTGCCCGGCTTT
GATGGTAACTGTGAAGGCAGCGGATTCCCAGTGGGTATTAAACAAGAACCAGATGACGGG
AGCTATTACCCAGAGGCCAGCATCCCTTCCTCTGCTATTGTTGGGGTGAATTCAGGTGGA
CAGTCCTTCCACTACAGGATTGGTGCTCAAGGTACAATATCTTTATCACGATCGGCTAGA
GACCAATCTTTCCAACACCTGAGTTCCTTTCCTCCTGTCAATACTTTAGTGGAGTCATGG
AAATCACACGGCGACCTGTCGTCTAGAAGAAGTGATGGGTATCCGGTCTTAGAATACATT
CCAGAAAATGTATCAAGCTCTACTTTACGAAGTGTTTCTACTGGATCTTCAAGACCTTCA
AAAATATGTTTGGTGTGTGGGGATGAGGCTTCAGGATGCCATTATGGGGTAGTCACCTGT
GGCAGCTGCAAAGTTTTCTTCAAAAGAGCAGTGGAAGGGCAACACAACTATTTATGTGCT
GGAAGAAATGATTGCATCATTGATAAGATTCGACGAAAGAATTGTCCTGCTTGCAGACTT
CAGAAATGTCTTCAAGCTGGAATGAATTTAGGAGCACGAAAGTCAAAGAAGTTGGGAAAG
TTAAAAGGGATTCACGAGGAGCAGCCACAGCAGCAGCAGCCCCCACCCCCACCCCCACCC
CCGCAAAGCCCAGAGGAAGGGACAACGTACATCGCTCCTGCAAAAGAACCCTCGGTCAAC
ACAGCACTGGTTCCTCAGCTCTCCACAATCTCACGAGCGCTCACACCTTCCCCCGTTATG
GTCCTTGAAAACATTGAACCTGAAATTGTATATGCAGGCTATGACAGCTCAAAACCAGAT
ACAGCCGAAAATCTGCTCTCCACGCTCAACCGCTTAGCAGGCAAACAGATGATCCAAGTC
GTGAAGTGGGCAAAGGTACTTCCAGGATTTAAAAACTTGCCTCTTGAGGACCAAATTACC
CTAATCCAGTATTCTTGGATGTGTCTATCATCATTTGCCTTGAGCTGGAGATCGTACAAA
CATACGAACAGCCAATTTCTCTATTTTGCACCAGACCTAGTCTTTAATGAAGAGAAGATG
CATCAGTCTGCCATGTATGAACTATGCCAGGGGATGCACCAAATCAGCCTTCAGTTCGTT
CGACTGCAGCTCACCTTTGAAGAATACACCATCATGAAAGTTTTGCTGCTACTAAGCACA
ATTCCAAAGGATGGCCTCAAAAGCCAGGCTGCATTTGAAGAAATGAGGACAAATTACATC
AAAGAACTGAGGAAGATGGTAACTAAGTGTCCCAACAATTCTGGGCAGAGCTGGCAGAGG
TTCTACCAACTGACCAAGCTGCTGGACTCCATGCATGACCTGGTGAGCGACCTGCTGGAA
TTCTGCTTCTACACCTTCCGAGAGTCCCATGCGCTGAAGGTAGAGTTCCCCGCAATGCTG
GTGGAGATCATCAGCGACCAGCTGCCCAAGGTGGAGTCGGGGAACGCCAAGCCGCTCTAC
TTCCACCGGAAGTGA

# Macromolecular_Interacting_Partner_23_GenBank_ID_Gene:
M16801

# Macromolecular_Interacting_Partner_23_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_23_Locus:
4q31.1

# Macromolecular_Interacting_Partner_23_SNPs:
rs5522; rs5527; rs12509135; rs5523; rs13306592; rs5525; rs5529; rs5524; rs5528; rs2070949; rs2871; rs5534; rs7658048; rs5536; rs2070951; rs2070950; rs5530; rs17024360; rs6814934; rs5533; rs5535; rs5537; rs5532; rs6822758; rs1879828; rs1994624; rs1512327; rs1403142; rs1512341; rs1532890; rs1512342; rs2063009; rs1546529; rs1403143; rs907620; rs2137335; rs1546531; rs2137330; rs2163172; rs993386; rs1879829; rs6857487; rs7668847; rs3910047; rs4835514; rs1512329; rs3920217; rs4835479; rs6812904; rs6857011; rs6844155; rs6535594; rs1040288; rs6823544; rs2063556; rs878152; rs3846309; rs11724226; rs6840127; rs10012553; rs7693776; rs6840141; rs10032020; rs4835128; rs1913023; rs11723856; rs6848375; rs6844424; rs3910054; rs2883929; rs4835486; rs10026568; rs7695118; rs12649394; rs4835500; rs6535581; rs2884445; rs3846307; rs7438918; rs13133240; rs9993133; rs6820751; rs1512332; rs6535590; rs6856803; rs3857084; rs11099695; rs4835485; rs3752701; rs12499873; rs3910056; rs6810951; rs3843411; rs6850597; rs11736161; rs10857231; rs3843410; rs2356210; rs9997090; rs6811001; rs6535583; rs3846329; rs3846318; rs4835494; rs1512337; rs10010766; rs4835488; rs6832421; rs907618; rs2048546; rs1858416; rs6535599; rs4835478; rs2272089; rs3846319; rs879206; rs11099690; rs13133379; rs6847959; rs7677409; rs1818448; rs3846302; rs1512344; rs7661835; rs1879827; rs6831376; rs11099680; rs4835490; rs6535580; rs13105361; rs1355613; rs6535597; rs3846306; rs10434100; rs4027073; rs6856424; rs7665528; rs4635799; rs4835516; rs3846317; rs6535598; rs6832393; rs6535584; rs6815984; rs2293162; rs10011595; rs3846322; rs2063555; rs11929719; rs3910044; rs1512343; rs13103641; rs6535577; rs1490453; rs2048547; rs6820304; rs13116347; rs7696770; rs6535579; rs12512126; rs7670229; rs10023128; rs907619; rs6535602; rs4835519; rs3931397; rs2137334; rs7691663; rs6828665; rs2883930; rs907621; rs6825530; rs10519942; rs11099681; rs6828378; rs745019; rs17024708; rs11725509; rs13117325; rs1987969; rs3910052; rs11937655; rs12511893; rs12647605; rs6849127; rs6849903; rs12711259; rs6849862; rs3846316; rs11733930; rs6854515; rs17024387; rs17581884; rs6817983; rs6817925; rs7693171; rs12641471; rs6535588; rs11736713; rs4835133; rs13147775; rs6535593; rs10050229; rs10018805; rs17484259; rs3925570; rs4087964; rs3846328; rs1512326; rs4835508; rs10026226; rs4835506; rs12711260; rs6831034; rs13137823; rs12506077; rs2063554; rs3887856; rs7691250; rs11099679; rs17620160; rs7670069; rs12507494; rs17620330; rs16998733; rs4835491; rs6826213; rs7680420; rs745020; rs12506058; rs11945778; rs17024397; rs6846614; rs13116332; rs9996961; rs4513547; rs17620775; rs6535596; rs12651282; rs3916013; rs12498662; rs10021848; rs3846312; rs11734888; rs10519945; rs992556; rs9631756; rs17484454; rs12499208; rs17483854; rs6816503; rs10519959; rs10034789; rs3846305; rs10004472; rs4594704; rs4087965; rs4260521; rs1546044; rs12640639; rs7694064; rs12508913; rs17620822; rs2358243; rs13112423; rs3846325; rs6831887; rs10031992; rs7698302; rs10519952; rs10031538; rs7694706; rs17581311; rs6826471; rs11735947; rs6826594; rs3911846; rs3910046; rs13150372; rs10519955; rs7683540; rs7673644; rs13137836; rs1512330; rs4835493; rs10434130; rs12642178; rs4087963; rs7655438; rs1398269; rs11728254; rs6813167; rs7698307; rs4835504; rs17024456; rs2137331; rs4835482; rs17024654; rs13119790; rs2883917; rs11732490; rs2063553; rs3846320; rs17483391; rs6857716; rs7670173; rs11733686; rs4579099; rs1996025; rs3843413; rs3846301; rs17620105; rs9997336; rs6851669; rs4835131; rs17484357; rs11946576; rs10519951; rs3733421; rs7683313; rs6839414; rs17484671; rs3910051; rs10024999; rs11099692; rs17483979; rs6855032; rs4083100; rs10519963; rs17024482; rs2063557; rs13142954; rs7693077; rs4835138; rs6814226; rs10031194; rs1522451; rs13146357; rs17484873; rs3910053; rs6831212; rs11099678; rs3846326; rs12331321; rs6834935; rs6825048; rs6813869; rs11724292; rs6823323; rs11731398; rs10519954; rs17483833; rs9991002; rs3857079; rs10033040; rs10032250; rs6849817; rs4835484; rs7661326; rs1512331; rs4835503; rs10519958; rs4835483; rs6535600; rs3910057; rs3846321; rs17484678; rs11730274; rs13116524; rs11737660; rs13144030; rs6818452; rs7699349; rs6836191; rs1512335; rs2358336; rs17024443; rs11726964; rs3846299; rs1429915; rs7672951; rs4835136; rs17024479; rs10002896; rs17024514; rs1911120; rs2137332; rs10519962; rs13123626; rs4835497; rs2115800; rs10026826; rs6836072; rs11099677; rs17024718; rs17484783; rs13116099; rs12639977; rs7670121; rs6819635; rs17024666; rs17582206; rs11721992; rs10857232; rs11943992; rs10025629; rs11932750; rs12511415; rs6813390; rs3846300; rs12510074; rs13118475; rs17024611; rs17484811; rs17024683; rs17024380; rs3857083; rs11933180; rs17024408; rs4835512; rs12506066; rs17580772; rs6836246; rs17582031; rs11099688; rs11730626; rs17024706; rs6849327; rs9761994; rs3846313; rs17483701; rs17485033; rs7666711; rs11731400; rs9762822; rs6846738; rs17024633; rs9685254; rs6857339; rs17024541; rs13129830; rs3910058; rs7668671; rs11099686; rs12500487; rs7673925; rs765491; rs12499901; rs7686433; rs3910060; rs2172002; rs17581262; rs7690849; rs6833880; rs17024678; rs10034882; rs17581570; rs4560389; rs17484839; rs17024631; rs9994262; rs7698917; rs17581787; rs6816918; rs7687754; rs11736341; rs17484118; rs2137336; rs7694200; rs11099689; rs12647354; rs17024704; rs2137333; rs17484622; rs17581815; rs1964691; rs17484447; rs17484245; rs9995951; rs1398268; rs17024437; rs13146865; rs6822617; rs12502713; rs7665347; rs17024516; rs1512336; rs9994862; rs13148853; rs17007968; rs6843485; rs17484601; rs17024518; rs1429914; rs3846323; rs17581905; rs7698289; rs2883879; rs9685269; rs4091074; rs9760992; rs6850820; rs9683768; rs9685938; rs11099694; rs11931777; rs17024512; rs1512334; rs11939588; rs9761239; rs17581605; rs7700126; rs9992964; rs17024364; rs6829058; rs3846308; rs11729617; rs6535592; rs17024509; rs17024506; rs13137095; rs1858415; rs7442442; rs17024717; rs6840422; rs3846310; rs11932031; rs11722863; rs2056471; rs6858581; rs12504040; rs10026186; rs17581220; rs6535578; rs6841404; rs9990620; rs13133487; rs13109933; rs7690778; rs7689925; rs17621119; rs2356374; rs17024579; rs3857082; rs13150785; rs11099683; rs6846591; rs4835487; rs2048548; rs17024720; rs17024469; rs6832062; rs17581975; rs10034617; rs4835502; rs6846217; rs11721799; rs13108130; rs10012907; rs7688969; rs1512328; rs17024715; rs17024681; rs10857233; rs1877445; rs6854045; rs17484063; rs11099687; rs11099685; rs7682972; rs9685272; rs4835505; rs10010607; rs10033445; rs4301087; rs11931989; rs4835513; rs3846304; rs11732130; rs3910059; rs1033123; rs3910055; rs12508062; rs35644313; rs13118022; rs6855341; rs34861534; rs11727894; rs17580954; rs10001430; rs17024404; rs907617; rs17484991; rs7688209; rs12648444; rs17581996; rs12645409; rs1949169; rs6844150; rs6857670; rs11722067; rs3846315; rs13116551; rs17024560; rs11099696; rs7658039; rs11936376; rs878232; rs7698965; rs4835129; rs11725360; rs17024401; rs17024556; rs1980278; rs10009023; rs10434128; rs17376692; rs6856000; rs9995276; rs6841570; rs6842079; rs4835489; rs12509783; rs17676810; rs10519948; rs6853764; rs10011581; rs17581898; rs6851178; rs7690691; rs17581947; rs9998790; rs7692281; rs1522450; rs3857080; rs6854097; rs6846376; rs17483687; rs17024565; rs7674206; rs3910050; rs12506373; rs10029951; rs17581115; rs6812538; rs1873174; rs7696997; rs6836320; rs2301280; rs11936965; rs17024347; rs2248038; rs13306591; rs41511344; rs5526; rs34905604; rs5531; rs6848862; rs35832836; rs35396139; rs6823133; rs10708334; rs12643841; rs1062595; rs35360139; rs35586342; rs10028821; rs11292717; rs1062596; rs34293064; rs2070948; rs34347300; rs35771619; rs17580982; rs28549338; rs34802206; rs34026733; rs35713600; rs35258027; rs35789402; rs35606529; rs3054606; rs11730006; rs34476486; rs10562720; rs13138913; rs35132207; rs5862831; rs4505803; rs7668619; rs34734628; rs3910049; rs11939631; rs13144019; rs34471942; rs28647457; rs28594566; rs28656810; rs11384270; rs34886346; rs13139652; rs34030364; rs1946524; rs10021521; rs7699303; rs33936062; rs34054905; rs13149418; rs11381991; rs34431006; rs6815979; rs34953252; rs7674857; rs17580639; rs35590380; rs34165580; rs35135883; rs11940423; rs34244163; rs35978319; rs17024635; rs13112076; rs3887324; rs1512333; rs28672384; rs35224048; rs9993593; rs35237809; rs35378267; rs35436474; rs981372; rs3857081; rs13104218; rs5862829; rs35681362; rs13121960; rs34159127; rs3843414; rs9631755; rs36034042; rs5862838; rs7699209; rs35201774; rs36182734; rs35264279; rs11378484; rs35714983; rs35933180; rs35464072; rs35423790; rs28605213; rs11930469; rs35186171; rs1522449; rs11332546; rs10605309; rs6822304; rs9762356; rs6829009; rs4501202; rs35976575; rs2137338; rs11381917; rs1522452; rs9997290; rs35907005; rs35562931; rs11416123; rs13108703; rs34987101; rs34152444; rs34611880; rs35337326; rs34236655; rs35111299; rs3846330; rs28441385; rs7679518; rs33937448; rs3846303; rs35282722; rs35595748; rs17620469; rs28377603; rs35809828; rs4027074; rs6839408; rs11733477; rs5862833; rs34529215; rs35563216; rs17024667; rs34997890; rs34279352; rs4835515; rs35480965; rs3846327; rs11944891; rs2293163; rs33971837; rs28379421; rs35496556; rs34440852; rs6826827; rs28698626; rs6852036; rs35126311; rs35152746; rs28465033; rs11361774; rs36135256; rs1946523; rs10026777; rs7678106; rs35607293; rs2115798; rs35549271; rs7680091; rs34975695; rs7682465; rs35198554; rs13112089; rs34530174; rs10034839; rs34469488; rs10716270; rs28805917; rs35947630; rs4447838; rs4835501; rs28372032; rs7678425; rs35095537; rs6815139; rs28367185; rs3843412; rs35190729; rs34364416; rs35944210; rs35557372; rs4835137; rs1355612; rs6535591; rs10003237; rs1546530; rs7673832; rs35827730; rs11362297; rs34296798; rs35058866; rs35315376; rs33962250; rs28798239; rs34298854; rs28698266; rs11349017; rs34206536; rs2356394; rs11725517; rs13132072; rs7691775; rs13137655; rs34453040; rs28639664; rs13111594; rs36012041; rs34621287; rs13434549; rs11386119; rs33973334; rs28723458; rs35806661; rs11099682; rs13108682; rs11935760; rs28837820; rs13132300; rs6815356; rs17024561; rs3045289; rs35258207; rs35591475; rs28702892; rs35992616; rs36196281; rs28604902; rs34170216; rs13137039; rs34489084; rs4295241; rs6819902; rs34825669; rs28462077; rs36032097; rs4621409; rs10434129; rs11723538; rs12641579; rs35653840; rs11343039; rs926019; rs9997923; rs4122853; rs982076; rs13104030; rs35344401; rs12647673; rs13133177; rs35283376; rs35263055; rs6846848; rs6840172; rs28633715; rs6819706; rs35745299; rs34782286; rs5862834; rs5862828; rs7659754; rs7693371; rs35041849; rs6817070; rs12639699; rs34440621; rs36112050; rs34599173; rs28621626; rs11936509; rs10593353; rs35161508; rs35920138; rs3846311; rs35304305; rs34043561; rs28693507; rs4122851; rs28487903; rs13104472; rs9762359; rs35691150; rs13119744; rs11418057; rs34120297; rs11325949; rs965333; rs11326129; rs4026975; rs28869632; rs34643750; rs35003454; rs3846314; rs34966836; rs41510346; rs11444261; rs34113900; rs11303019; rs13138584; rs28482137; rs4027011; rs4293768; rs35554261; rs10528442; rs4835135; rs5862836; rs11459183; rs13118302; rs11440077; rs9992528; rs11323955; rs9654229; rs34090627; rs35633620; rs2102324; rs17304693; rs6838741; rs10586000; rs28789690; rs35476181; rs10654553; rs10624932; rs6833414; rs28645256; rs28834470; rs13132292; rs2358393; rs13139639; rs2358391; rs35101629; rs11724707; rs35649035; rs6831382; rs35957063; rs28367516; rs35414407; rs13105220; rs35574035; rs28408866; rs35013118; rs6535601; rs33924907; rs35672392; rs35706591; rs1033124; rs10023233; rs10025943; rs28377573; rs10650773; rs1911121; rs35087243; rs13104077; rs7670108; rs17024702; rs33913235; rs34874638; rs35954987; rs28663510; rs35637413; rs13120238; rs34771380; rs7678730; rs35697753; rs10008590; rs28593291; rs6535589; rs35210835; rs34273091; rs12507179; rs3053707; rs11363070; rs34012726; rs35945803; rs9993239; rs34416910; rs35504843; rs13145279; rs3927189; rs34311799; rs35146790; rs35181235; rs4835134; rs9992738; rs34374593; rs35318150; rs3752699; rs28588362; rs10607471; rs35749628; rs35992633; rs6854073; rs34815731; rs34799906; rs34810874; rs7668163; rs6535595; rs28711864; rs35264971; rs6814250; rs28369259; rs11940211; rs35083876; rs13144897; rs11320471; rs13127625; rs7438191; rs33955319; rs6148713; rs35899657; rs13129427; rs9994070; rs2137337; rs3910045; rs3045291; rs28408757; rs7375748; rs34408397; rs34019225; rs6852213; rs13136461; rs34980641; rs28802981; rs28542380; rs7661019; rs13132447; rs4835496; rs34189207; rs7685078; rs11365652; rs11947170; rs35303613; rs11324908; rs11731514; rs4613545; rs34201038; rs35227232; rs1039661; rs5862830; rs1913024; rs10019500; rs28886306; rs28505258; rs13123890; rs36193232; rs12650807; rs35870945; rs35700532; rs10050039; rs28376416; rs1057582; rs34880037; rs17024607; rs13149615; rs34890688; rs9994750; rs2884444; rs3857078; rs34704824; rs28648617; rs4122852; rs28612659; rs2356396; rs13104128; rs34636256; rs13136278; rs35441871; rs36048118; rs28657475; rs3846324; rs6823228; rs36084095; rs10857229; rs13107326; rs34499764; rs4027071; rs7670548; rs36145086; rs36150442; rs35832966; rs34625634; rs11330551; rs3041314; rs11363007; rs2115799; rs10648420; rs10008249; rs13142928; rs28464586; rs35591857; rs35550474; rs35903741; rs13146516; rs34946425; rs10564985; rs35545904; rs7377312; rs6854734; rs35593495; rs7668604; rs13119375; rs6818829; rs34936098; rs34272449; rs10434126; rs36036329; rs13112083; rs35000747; rs4611905; rs36084759; rs6827966; rs35940027; rs5862832; rs35659747; rs34400301; rs6831307; rs1512338; rs34618929; rs11324608; rs9999121; rs33928091; rs35667348; rs13109808; rs1506485; rs34896196; rs34217783; rs28407287; rs4835130; rs34576468; rs35162529; rs13133715; rs34220553; rs36127895; rs28368806; rs34718720; rs10593354; rs34580575; rs11727220; rs6854552; rs10026691; rs9995733; rs34168257; rs13115808; rs10608177; rs13134017; rs13103165; rs7438145; rs13106019; rs35504492; rs1512325; rs11384324; rs4560386; rs35925584; rs28696868; rs36041499; rs13137647; rs28897121; rs35642551; rs28507515; rs34868943; rs34430699; rs34051019; rs11722362; rs13132931; rs28622386; rs34346258; rs34696054; rs12511445; rs34317333; rs28391722; rs11386118; rs35741966; rs2356395; rs34642043; rs13109056; rs35311918; rs35979588; rs28529230; rs1429913; rs34163190; rs11335509; rs7656855; rs13104051; rs35367551; rs3045288; rs35932147; rs4835495; rs6839999; rs34372017; rs36114978; rs2358392; rs3906618; rs13125410; rs958785; rs13129690; rs4413384; rs36047772; rs35681147; rs995567; rs34623514; rs35762686; rs3902512; rs6846368; rs9993590; rs35118070; rs13139638; rs2037480; rs34918298; rs35694427; rs7682951; rs6852299; rs35541483; rs28851025; rs28498606; rs35070877; rs2356393; rs35820273; rs34948284; rs2174607; rs34358139; rs6841588; rs35325933; rs13133533; rs1398267; rs34152264; rs3910048; rs34438391; rs6840095; rs35756472; rs13114315; rs11377568; rs35022514; rs1512340; rs35079121; rs28500506; rs28398455; rs12331046; rs10542552; rs34209795; rs5862837; rs35441978; rs10012283; rs28696003; rs35542382; rs11726122; rs34294859; rs35115274; rs35534927; rs28770279; rs35338709; rs34927488; rs6854559; rs10034151; rs28452605; rs5862835; rs28848778; rs28607266; rs3216799; rs13306590; rs885859; rs34063900; rs6834026; rs7672177; rs34064829; rs885858; rs34022568; rs7671250; rs28742132; rs10689483; rs34706003; rs10213471; rs1039662; rs1039663; rs11099676; rs11728788; rs11933330; rs11933380; rs12499434; rs12641566; rs13111300; rs13141425; rs13148438; rs1490464; rs1490465; rs1546043; rs17024337; rs1907076; rs34158761; rs35815539; rs3884525; rs5521; rs6824449; rs7377816; rs906124; rs9307847; rs9724

# Macromolecular_Interacting_Partner_23_General_References:
3037703; 11518808; 9662404; 1655735; 7495694; 9141514; 9392437; 9724527; 10760050; 10935545; 11350956; 10391210; 11134129; 10884226; 12483305

# Macromolecular_Interacting_Partner_23_References:
15361767; 15479953; 15489962; 15511634

# Macromolecular_Interacting_Partner_24_ID:
8258

# Macromolecular_Interacting_Partner_24_Name:
ADM precursor [Contains: Adrenomedullin

# Macromolecular_Interacting_Partner_24_Synonyms:
AM; Proadrenomedullin N-20 terminal peptide; ProAM-N20; ProAM N-terminal 20 peptide; PAMP]

# Macromolecular_Interacting_Partner_24_Gene_Name:
ADM

# Macromolecular_Interacting_Partner_24_Protein_Sequence:
>ADM precursor Contains: Adrenomedullin
MKLVSVALMYLGSLAFLGADTARLDVASEFRKKWNKWALSRGKRELRMSSSYPTGLADVK
AGPAQTLIRPQDMKGASRSPEDSSPDAARIRVKRYRQSMNNFQGLRSFGCRFGTCTVQKL
AHQIYQFTDKDKDNVAPRSKISPQGYGRRRRRSLPEAGPGRTLVSSKPQAHGAPAPPSGS
APHFL

# Macromolecular_Interacting_Partner_24_Number_of_Residues:
185

# Macromolecular_Interacting_Partner_24_Molecular_Weight:
20421

# Macromolecular_Interacting_Partner_24_Theoretical_pI:
11.45

# Macromolecular_Interacting_Partner_24_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_24_General_Function:
Not Available

# Macromolecular_Interacting_Partner_24_Specific_Function:
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels

# Macromolecular_Interacting_Partner_24_Pathway:
Not Available

# Macromolecular_Interacting_Partner_24_Reaction:
Not Available

# Macromolecular_Interacting_Partner_24_Pfam_Domain_Function:
PF02039:Adrenomedullin

# Macromolecular_Interacting_Partner_24_Signals:
1-21

# Macromolecular_Interacting_Partner_24_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_24_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_24_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_24_GenBank_ID_Protein:
500612

# Macromolecular_Interacting_Partner_24_SwissProt_ID:
ADML_HUMAN (P35318)

# Macromolecular_Interacting_Partner_24_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_24_Genecard_id:
ADM

# Macromolecular_Interacting_Partner_24_Geneatlas_id:
ADM

# Macromolecular_Interacting_Partner_24_hgnc_id:
HGNC:259

# Macromolecular_Interacting_Partner_24_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_24_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_24_Gene_Sequence:
>558 bp
ATGAAGCTGGTTTCCGTCGCCCTGATGTACCTGGGTTCGCTCGCCTTCCTAGGCGCTGAC
ACCGCTCGGTTGGATGTCGCGTCGGAGTTTCGAAAGAAGTGGAATAAGTGGGCTCTGAGT
CGTGGGAAGAGGGAACTGCGGATGTCCAGCAGCTACCCCACCGGGCTCGCTGACGTGAAG
GCCGGGCCTGCCCAGACCCTTATTCGGCCCCAGGACATGAAGGGTGCCTCTCGAAGCCCC
GAAGACAGCAGTCCGGATGCCGCCCGCATCCGAGTCAAGCGCTACCGCCAGAGCATGAAC
AACTTCCAGGGCCTCCGGAGCTTTGGCTGCCGCTTCGGGACGTGCACGGTGCAGAAGCTG
GCACACCAGATCTACCAGTTCACAGATAAGGACAAGGACAACGTCGCCCCCAGGAGCAAG
ATCAGCCCCCAGGGCTACGGCCGCCGGCGCCGGCGCTCCCTGCCCGAGGCCGGCCCGGGT
CGGACTCTGGTGTCTTCTAAGCCACAAGCACACGGGGCTCCAGCCCCCCCGAGTGGAAGT
GCTCCCCACTTTCTTTAG

# Macromolecular_Interacting_Partner_24_GenBank_ID_Gene:
D14874

# Macromolecular_Interacting_Partner_24_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_24_Locus:
11p15.4

# Macromolecular_Interacting_Partner_24_SNPs:
rs5005; rs2228573; rs13306112; rs4698; rs34354539; rs5008; rs35440828; rs13306113; rs5010; rs5002; rs5000; rs11042725; rs35010473; rs5009; rs13306110; rs3814700; rs5004; rs11542824; rs5006; rs34779934; rs1126716; rs35527436; rs34570663; rs5003; rs1126517; rs5007; rs35385980; rs13306111; rs34056369; rs5001; rs34093904; rs11298480; rs11042726; rs11042727; rs11042728; rs11042730; rs12796499; rs1450265; rs1450266; rs1450268; rs17296765; rs2060658; rs4076050; rs4077089; rs4399321; rs4403799; rs4444073; rs4641466; rs4910118; rs7108385; rs7924631; rs7927874; rs7935242; rs7944706; rs9787937

# Macromolecular_Interacting_Partner_24_General_References:
7688224; 8074714; 8387282; 9578982; 10588445

# Macromolecular_Interacting_Partner_24_References:
15361767

# Macromolecular_Interacting_Partner_25_ID:
7752

# Macromolecular_Interacting_Partner_25_Name:
Amiloride-sensitive sodium channel subunit alpha

# Macromolecular_Interacting_Partner_25_Synonyms:
Epithelial Na(+channel subunit alpha; Alpha ENaC; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA; Alpha NaCH

# Macromolecular_Interacting_Partner_25_Gene_Name:
SCNN1A

# Macromolecular_Interacting_Partner_25_Protein_Sequence:
>Amiloridesensitive sodium channel subunit alpha
MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFE
FFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINL
NSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDL
RGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQT
YSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHP
MYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA
FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSC
FQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS
VTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESP
SVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGR
GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGAS
SSTCPLGGP

# Macromolecular_Interacting_Partner_25_Number_of_Residues:
669

# Macromolecular_Interacting_Partner_25_Molecular_Weight:
75704

# Macromolecular_Interacting_Partner_25_Theoretical_pI:
7.54

# Macromolecular_Interacting_Partner_25_GO_Classification:
>>>
Function:  transporter activity
Function:  ion transporter activity
Function:  ion channel activity
Function:  cation channel activity
Function:  sodium channel activity
Function:  amiloride-sensitive sodium channel activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  cation transport
Process:  monovalent inorganic cation transport
Process:  sodium ion transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_25_General_Function:
Not Available

# Macromolecular_Interacting_Partner_25_Specific_Function:
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception

# Macromolecular_Interacting_Partner_25_Pathway:
Not Available

# Macromolecular_Interacting_Partner_25_Reaction:
Not Available

# Macromolecular_Interacting_Partner_25_Pfam_Domain_Function:
PF00858:ASC

# Macromolecular_Interacting_Partner_25_Signals:
None

# Macromolecular_Interacting_Partner_25_Transmembrane_Regions:
86-106
563-583

# Macromolecular_Interacting_Partner_25_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_25_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_25_GenBank_ID_Protein:
452650

# Macromolecular_Interacting_Partner_25_SwissProt_ID:
SCNNA_HUMAN (P37088)

# Macromolecular_Interacting_Partner_25_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_25_Genecard_id:
SCNN1A

# Macromolecular_Interacting_Partner_25_Geneatlas_id:
SCNN1A

# Macromolecular_Interacting_Partner_25_hgnc_id:
HGNC:10599

# Macromolecular_Interacting_Partner_25_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_25_Subcellular_Location:
Cell membrane; apical cell membrane; multi- pass membrane protein. Note=Apical membrane of epithelial cells

# Macromolecular_Interacting_Partner_25_Gene_Sequence:
>2010 bp
ATGGAGGGGAACAAGCTGGAGGAGCAGGACTCTAGCCCTCCACAGTCCACTCCAGGGCTC
ATGAAGGGGAACAAGCGTGAGGAGCAGGGGCTGGGCCCCGAACCTGCGGCGCCCCAGCAG
CCCACGGCGGAGGAGGAGGCCCTGATCGAGTTCCACCGCTCCTACCGAGAGCTCTTCGAG
TTCTTCTGCAACAACACCACCATCCACGGCGCCATCCGCCTGGTGTGCTCCCAGCACAAC
CGCATGAAGACGGCCTTCTGGGCAGTGCTGTGGCTCTGCACCTTTGGCATGATGTACTGG
CAATTCGGCCTGCTTTTCGGAGAGTACTTCAGCTACCCCGTCAGCCTCAACATCAACCTC
AACTCGGACAAGCTCGTCTTCCCCGCAGTGACCATCTGCACCCTCAATCCCTACAGGTAC
CCGGAAATTAAAGAGGAGCTGGAGGAGCTGGACCGCATCACAGAGCAGACGCTCTTTGAC
CTGTACAAATACAGCTCCTTCACCACTCTCGTGGCCGGCTCCCGCAGCCGTCGCGACCTG
CGGGGGACTCTGCCGCACCCCTTGCAGCGCCTGAGGGTCCCGCCCCCGCCTCACGGGGCC
CGTCGAGCCCGTAGCGTGGCCTCCAGCTTGCGGGACAACAACCCCCAGGTGGACTGGAAG
GACTGGAAGATCGGCTTCCAGCTGTGCAACCAGAACAAATCGGACTGCTTCTACCAGACA
TACTCATCAGGGGTGGATGCGGTGAGGGAGTGGTACCGCTTCCACTACATCAACATCCTG
TCGAGGCTGCCAGAGACTCTGCCATCCCTGGAGGAGGACACGCTGGGCAACTTCATCTTC
GCCTGCCGCTTCAACCAGGTCTCCTGCAACCAGGCGAATTACTCTCACTTCCACCACCCG
ATGTATGGAAACTGCTATACTTTCAATGACAAGAACAACTCCAACCTCTGGATGTCTTCC
ATGCCTGGAATCAACAACGGTCTGTCCCTGATGCTGCGCGCAGAGCAGAATGACTTCATT
CCCCTGCTGTCCACAGTGACTGGGGCCCGGGTAATGGTGCACGGGCAGGATGAACCTGCC
TTTATGGATGATGGTGGCTTTAACTTGCGGCCTGGCGTGGAGACCTCCATCAGCATGAGG
AAGGAAACCCTGGACAGACTTGGGGGCGATTATGGCGACTGCACCAAGAATGGCAGTGAT
GTTCCTGTTGAGAACCTTTACCCTTCAAAGTACACACAGCAGGTGTGTATTCACTCCTGC
TTCCAGGAGAGCATGATCAAGGAGTGTGGCTGTGCCTACATCTTCTATCCGCGGCCCCAG
AACGTGGAGTACTGTGACTACAGAAAGCACAGTTCCTGGGGGTACTGCTACTATAAGCTC
CAGGTTGACTTCTCCTCAGACCACCTGGGCTGTTTCACCAAGTGCCGGAAGCCATGCAGC
GTGACCAGCTACCAGCTCTCTGCTGGTTACTCACGATGGCCCTCGGTGACATCCCAGGAA
TGGGTCTTCCAGATGCTATCGCGACAGAACAATTACACCGTCAACAACAAGAGAAATGGA
GTGGCCAAAGTCAACATCTTCTTCAAGGAGCTGAACTACAAAACCAATTCTGAGTCTCCC
TCTGTCACGATGGTCACCCTCCTGTCCAACCTGGGCAGCCAGTGGAGCCTGTGGTTCGGC
TCCTCGGTGTTGTCTGTGGTGGAGATGGCTGAGCTCGTCTTTGACCTGCTGGTCATCATG
TTCCTCATGCTGCTCCGAAGGTTCCGAAGCCGATACTGGTCTCCAGGCCGAGGGGGCAGG
GGTGCTCAGGAGGTAGCCTCCACCCTGGCATCCTCCCCTCCTTCCCACTTCTGCCCCCAC
CCCATGTCTCTGTCCTTGTCCCAGCCAGGCCCTGCTCCCTCTCCAGCCTTGACAGCCCCT
CCCCCTGCCTATGCCACCCTGGGCCCCCGCCCATCTCCAGGGGGCTCTGCAGGGGCCAGT
TCCTCCACCTGTCCTCTGGGGGGGCCCTGA

# Macromolecular_Interacting_Partner_25_GenBank_ID_Gene:
X76180

# Macromolecular_Interacting_Partner_25_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_25_Locus:
12p13

# Macromolecular_Interacting_Partner_25_SNPs:
rs2228576; rs5742912; rs3741913; rs3764873; rs10849447; rs6489713; rs11614164; rs4764585; rs6489712; rs3764875; rs2286600; rs7972292; rs3741914; rs3782722; rs6489711; rs3782726; rs7976804; rs13306613; rs7973914; rs7968695; rs2041375; rs4764587; rs3782724; rs10849445; rs4764586; rs7296922; rs10849446; rs7956915; rs3764874; rs2364468; rs10774426; rs3782727; rs17725256; rs12304937; rs7958135; rs2534691; rs7972942; rs11064151; rs7963228; rs2534692; rs12581183; rs3782721; rs3782728; rs10774429; rs12579898; rs2886081; rs11064148; rs12322266; rs10774428; rs7957162; rs2532487; rs4491294; rs11064149; rs13306614; rs10774427; rs3782725; rs3782723; rs11064145; rs3759324; rs7297961; rs11831941; rs16932569; rs11608320; rs3759323; rs2071244; rs2364476; rs11833597; rs879605; rs13306616; rs11542844; rs11542843; rs17846607; rs13306619; rs13306618; rs13306617; rs34602363; rs11064150; rs12810735; rs11609789; rs13306621; rs35965494; rs12424134; rs35041216; rs34021000; rs12315455; rs34164551; rs10612411; rs11612314; rs12582338; rs11366729; rs35065658; rs13306620; rs10650761; rs35673511; rs35431612; rs7981003; rs12320672; rs12582636; rs7302949; rs34075843; rs12422366; rs34080023; rs34772874; rs6489714; rs3831763; rs2364473; rs12825322; rs2268008; rs35451673; rs41279086; rs7964163; rs12826912; rs34910948; rs7954060; rs28639508; rs34138854; rs35937239; rs10677875; rs12312293; rs11608322; rs34933785; rs34112282; rs35215657; rs34140670; rs11064152; rs7978675; rs34067413; rs36100233; rs3834495; rs1042318; rs10849448; rs11064153; rs11608700; rs1860545; rs2234649; rs2302256; rs3759333; rs3759334; rs4149570; rs4149573; rs4149576; rs4149577; rs4149578; rs4149579; rs4149580; rs4149581; rs4149621; rs4149622; rs4149623; rs4149626; rs4149627; rs4149629; rs4285931; rs4441073; rs767455

# Macromolecular_Interacting_Partner_25_General_References:
8278374; 8023962; 9654208; 10447117; 9612219; 11266509; 9575806; 9169421; 12167593; 10404817; 10586178

# Macromolecular_Interacting_Partner_25_References:
15673309; 16236820; 16332930; 16613846

# Macromolecular_Interacting_Partner_26_ID:
8324

# Macromolecular_Interacting_Partner_26_Name:
Sodium/hydrogen exchanger 3

# Macromolecular_Interacting_Partner_26_Synonyms:
Na(+/H(+exchanger 3; NHE-3; Solute carrier family 9 member 3

# Macromolecular_Interacting_Partner_26_Gene_Name:
SLC9A3

# Macromolecular_Interacting_Partner_26_Protein_Sequence:
>Sodium/hydrogen exchanger 3
MWGLGARGPDRGLLLALALGGLARAGGVEVEPGGAHGESGGFQVVTFEWAHVQDPYVIAL
WILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLL
PPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLD
FLLFGSLMAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGD
NVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLT
SEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVN
PFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAF
ALVVLLDGDKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLH
GRAFDHILSAIEDISGQIGHNYLRDKWSHFDRKFLSRVLMRRSAQKSRDRILNVFHELNL
KDAISYVAEGERRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQS
LEQRRRSIRDAEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKR
LESFKSTKLGLNQNKKAAKLYKRERAQKRRNSSIPNGKLPMESPAQNFTIKEKDLELSDT
EEPPNYDEEMSGGIEFLASVTKDTASDSPAGIDNPVFSPDEALDRSLLARLPPWLSPGET
VVPSQRARTQIPYSPGTFRRLMPFRLSSKSVDSFLQADGPEERPPAALPESTHM

# Macromolecular_Interacting_Partner_26_Number_of_Residues:
834

# Macromolecular_Interacting_Partner_26_Molecular_Weight:
92909

# Macromolecular_Interacting_Partner_26_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_26_GO_Classification:
>>>
Function:  monovalent inorganic cation transporter activity
Function:  hydrogen ion transporter activity
Function:  monovalent cation:proton antiporter activity
Function:  sodium:hydrogen antiporter activity
Function:  transporter activity
Function:  ion transporter activity
Function:  cation transporter activity
Function:  solute:cation antiporter activity
Function:  solute:hydrogen antiporter activity
 ||
>>>
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  cation transport
Process:  monovalent inorganic cation transport
Process:  sodium ion transport
Process:  physiological process
Process:  homeostasis
Process:  ion homeostasis
Process:  regulation of pH
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_26_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_26_Specific_Function:
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction

# Macromolecular_Interacting_Partner_26_Pathway:
Not Available

# Macromolecular_Interacting_Partner_26_Reaction:
Not Available

# Macromolecular_Interacting_Partner_26_Pfam_Domain_Function:
PF00999:Na_H_Exchanger

# Macromolecular_Interacting_Partner_26_Signals:
1-25

# Macromolecular_Interacting_Partner_26_Transmembrane_Regions:
80-99
113-133
140-160
181-202
211-232
253-274
291-309
341-362
370-390
436-456

# Macromolecular_Interacting_Partner_26_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_26_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_26_GenBank_ID_Protein:
971209

# Macromolecular_Interacting_Partner_26_SwissProt_ID:
SL9A3_HUMAN (P48764)

# Macromolecular_Interacting_Partner_26_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_26_Genecard_id:
SLC9A3

# Macromolecular_Interacting_Partner_26_Geneatlas_id:
SLC9A3

# Macromolecular_Interacting_Partner_26_hgnc_id:
HGNC:11073

# Macromolecular_Interacting_Partner_26_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_26_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_26_Gene_Sequence:
>2505 bp
ATGTGGGGACTCGGGGCCCGGGGCCCCGACCGGGGGCTGCTGCTGGCGCTGGCGCTGGGC
GGGCTGGCGCGGGCCGGGGGCGTCGAGGTGGAGCCCGGCGGCGCGCACGGCGAGAGCGGG
GGCTTCCAGGTGGTCACCTTCGAGTGGGCCCACGTGCAGGATCCCTACGTCATCGCGCTC
TGGATCCTCGTGGCCAGCTTGGCCAAGATCGGGTTCCACCTGTCCCACAAGGTCACCAGC
GTGGTTCCCGAGAGCGCCCTGCTCATCGTGCTGGGCCTGGTGCTGGGCGGCATCGTCTGG
GCGGCCGACCACATCGCGTCCTTCACACTGACGCCCACCGTCTTCTTCTTCTACCTGCTG
CCCCCCATCGTGCTGGACGCCGGCTACTTCATGCCCAACCGCCTCTTCTTCGGCAACCTG
GGGACCATCCTGTTGTACGCCGTCGTGGGTACCGTGTGGAACGCGGCCACCACCGGGCTG
TCCCTCTACGGCGTCTTCCTCAGTGGGCTCATGGGCGACCTGCAGATTGGGCTGCTGGAC
TTCCTCCTGTTTGGCAGCCTCATGGCGGCTGTGGACCCGGTGGCCGTCCTGGCCGTGTTT
GAGGAGGTCCATGTCAACGAGGTCCTGTTCATCATCGTCTTCGGGGAGTCGCTGCTGAAC
GACGCAGTCACCGTGGTTCTGTACAATGTGTTTGAATCTTTCGTGGCGCTGGGAGGTGAC
AACGTGACTGGCGTGGACTGCGTGAAGGGCATAGTGTCCTTCTTCGTGGTGAGCCTGGGG
GGCACGCTGGTGGGGGTGGTCTTCGCCTTCCTGCTGTCGCTGGTGACGCGCTTCACCAAG
CATGTGCGTATCATCGAGCCCGGCTTCGTGTTCATCATCTCCTACCTGTCCTACCTGACG
TCCGAGATGCTGTCGCTGTCGGCCATCCTCGCCATCACCTTCTGTGGCATCTGCTGTCAG
AAGTATGTGAAGGCCAACATCTCGGAGCAGTCGGCCACCACCGTGCGCTACACCATGAAG
ATGCTGGCCAGCAGCGCCGAGACCATCATCTTCATGTTCCTGGGTATCTCGGCCGTGAAC
CCGTTCATCTGGACCTGGAACACGGCCTTCGTGCTCCTGACGCTGGTCTTCATCTCCGTG
TACCGGGCCATCGGTGTGGTCCTGCAGACCTGGCTTCTGAACCGCTACCGCATGGTGCAG
CTGGAGCCCATTGACCAGGTGGTCCTGTCCTACGGGGGCCTGCGCGGGGCCGTGGCCTTT
GCCCTGGTGGTGCTTCTGGATGGAGACAAGGTCAAGGAGAAGAACCTGTTCGTCAGCACC
ACCATCATCGTAGTGTTCTTCACCGTCATCTTCCAGGGCCTGACCATCAAGCCTCTGGTG
CAGTGGCTGAAGGTGAAGAGGAGCGAGCACCGGGAACCTCGGCTCAACGAGAAGCTGCAC
GGCCGCGCTTTCGACCACATCCTCTCGGCCATCGAGGACATATCCGGACAGATCGGGCAC
AATTATCTCAGAGACAAGTGGTCCCACTTCGACAGGAAGTTCCTCAGCAGGGTCCTCATG
AGACGGTCGGCCCAGAAGTCTCGAGACCGGATCCTGAATGTCTTCCACGAGCTGAACCTG
AAGGATGCCATCAGCTACGTGGCTGAGGGAGAGCGCCGCGGGTCCCTGGCCTTCATCCGC
TCCCCCAGCACCGACAACGTGGTCAACGTGGACTTCACGCCACGATCGTCCACCGTGGAG
GCCTCTGTCTCCTACCTCCTGAGAGAAAATGTCAGCGCTGTCTGCCTGGACATGCAGTCT
CTGGAGCAGCGACGGCGGAGCATCCGGGACGCGGAGGACATGGTCACGCACCACACGCTA
CAGCAGTACCTGTACAAGCCGCGGCAGGAGTACAAGCATCTGTACAGCCGACACGAGCTC
ACGCCCACGGAGGACGAGAAACAGGACCGGGAAATCTTCCACAGGACCATGCGGAAGCGC
CTGGAGTCCTTCAAGTCGACCAAGCTGGGGCTCAACCAGAACAAGAAGGCAGCCAAGCTG
TACAAGCGGGAGCGTGCCCAGAAGCGGAGAAACAGCAGCATCCCCAATGGGAAGCTGCCC
ATGGAGAGCCCTGCGCAGAATTTCACCATCAAGGAGAAAGACTTGGAACTTTCAGACACC
GAGGAGCCCCCCAACTATGATGAGGAGATGAGTGGGGGGATCGAGTTCCTGGCTAGTGTC
ACCAAGGACACAGCGTCCGACTCCCCTGCAGGAATTGACAACCCTGTGTTTTCTCCGGAC
GAGGCCCTGGACCGCAGCCTCCTGGCCAGGCTGCCGCCCTGGCTGTCTCCCGGGGAGACG
GTGGTCCCCTCGCAGAGGGCCCGCACGCAGATTCCCTACTCTCCCGGCACCTTCCGCCGC
CTGATGCCCTTCCGCCTCAGCAGCAAGTCCGTGGACTCCTTCCTGCAGGCAGACGGCCCC
GAGGAGCGGCCCCCCGCCGCCCTCCCCGAGTCCACACACATGTGA

# Macromolecular_Interacting_Partner_26_GenBank_ID_Gene:
U28043

# Macromolecular_Interacting_Partner_26_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_26_Locus:
5p15.3

# Macromolecular_Interacting_Partner_26_SNPs:
rs3777231; rs6870920; rs9885312; rs2230437; rs3777230; rs12657631; rs6555316; rs6864158; rs6891049; rs890979; rs10475279; rs4957059; rs2278252; rs3734141; rs6868535; rs10475268; rs12716164; rs890980; rs6891064; rs4345352; rs11748526; rs2241597; rs11746573; rs13165421; rs890985; rs11134081; rs10078774; rs4957061; rs2434389; rs2278254; rs13357643; rs890983; rs11134071; rs9764991; rs6879352; rs2244240; rs890981; rs12716163; rs10475276; rs13158034; rs3777234; rs890978; rs12652789; rs4263057; rs4957045; rs12522575; rs11738544; rs2244223; rs2278247; rs6869648; rs11134082; rs890984; rs925693; rs11134072; rs11134080; rs4956940; rs6555317; rs11740933; rs11743305; rs10475282; rs2247107; rs11134078; rs3777233; rs13436079; rs3756711; rs7443244; rs6872510; rs10462621; rs890977; rs2434377; rs11746373; rs12109836; rs12716166; rs4957043; rs3777226; rs12657794; rs7709376; rs6872583; rs13153157; rs3836908; rs4956947; rs13436080; rs11950405; rs3734137; rs6882664; rs11747348; rs10076162; rs12520842; rs12716167; rs4245971; rs12519017; rs3734139; rs2458820; rs4956949; rs12515615; rs890986; rs6869782; rs7444581; rs10475269; rs12521198; rs11957707; rs10475280; rs11955160; rs3734138; rs11748410; rs4957044; rs6892166; rs2303736; rs4502351; rs6894329; rs9885589; rs6859852; rs4271701; rs13359853; rs10462622; rs3836909; rs7445979; rs17563161; rs6420045; rs2458814; rs1043356; rs12521236; rs6869609; rs13177896; rs890976; rs4956939; rs6879351; rs7721583; rs6555303; rs13356700; rs11950404; rs890982; rs6863511; rs1560173; rs10475283; rs890973; rs1053247; rs13154302; rs41282627; rs3777232; rs34257190; rs41282629; rs36074164; rs34939525; rs35054464; rs34644402; rs10073235; rs34275631; rs11745923; rs4334924; rs28590222; rs7718175; rs34022500; rs35604682; rs28419449; rs12188162; rs36213761; rs35873489; rs10580563; rs7704351; rs7380218; rs4957046; rs10076947; rs35941359; rs12516111; rs5865334; rs34168120; rs10659788; rs34362833; rs13173342; rs11747879; rs7733384; rs33927212; rs4957042; rs11739047; rs13154119; rs36019395; rs35784759; rs34701766; rs34719061; rs12054954; rs11385632; rs34820209; rs34121997; rs34154349; rs41282631; rs10475270; rs6889955; rs34537509; rs10572355; rs7713070; rs11743825; rs4957047; rs33992584; rs938324; rs7378626; rs13170444; rs4957060; rs35227727; rs2303735; rs36161633; rs7725551; rs13359721; rs35697323; rs35710918; rs7445970; rs34406484; rs11950353; rs6555324; rs35600787; rs10078684; rs11338472; rs2458819; rs13360817; rs10053300; rs5865333; rs6888815; rs34293895; rs11741234; rs3734140; rs13168935; rs11955896; rs3211145; rs13152890; rs34562440; rs7736622; rs34834059; rs35878814; rs35145443; rs10062053; rs35346581; rs10065644; rs34033998; rs35159055; rs4520963; rs35051913; rs13186188; rs35858723; rs33925304; rs11954611; rs2721030; rs10475275; rs10551484; rs12188556; rs13174780; rs13359797; rs2303737; rs36083128; rs10475271; rs34004700; rs11385633; rs4956948; rs3832380; rs36124859; rs36160359; rs11747491; rs11956075; rs11269302; rs7735595; rs13181243; rs35715105; rs13189685; rs35671785; rs10067184; rs12109483; rs3214559; rs34590639; rs28619154; rs41282625; rs2278253; rs34160944; rs34358734; rs2303734; rs12110079; rs35004250; rs2560732; rs7700827; rs2672029; rs7723049; rs33997355; rs10073165; rs1035908; rs1035909; rs10474780; rs1053226; rs1053233; rs1053257; rs1053299; rs11169; rs1139706; rs13162508; rs2247114; rs2434695; rs2434697; rs2561667; rs2561676; rs2672028; rs2672032; rs2721014; rs3315; rs36111336; rs3777225; rs3815928; rs3815929; rs3853656; rs3867180; rs3915786; rs4591794; rs4957063; rs6896261; rs699644; rs7726057; rs772659; rs890974

# Macromolecular_Interacting_Partner_26_General_References:
7631746

# Macromolecular_Interacting_Partner_26_References:
16251474; 16543718; 16757729

# Macromolecular_Interacting_Partner_27_ID:
8440

# Macromolecular_Interacting_Partner_27_Name:
Amiloride-sensitive sodium channel subunit gamma

# Macromolecular_Interacting_Partner_27_Synonyms:
Epithelial Na(+channel subunit gamma; Gamma ENaC; Nonvoltage-gated sodium channel 1 subunit gamma; SCNEG; Gamma NaCH

# Macromolecular_Interacting_Partner_27_Gene_Name:
SCNN1G

# Macromolecular_Interacting_Partner_27_Protein_Sequence:
>Amiloridesensitive sodium channel subunit gamma
MAPGEKIKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFT
LTAVALILWQCALLVFSFYTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQE
TREALKSLYGFPESRKRREAESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKR
KVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQ
VPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMG
GSEYGLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLT
ESFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAA
NYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWL
LPVLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMS
CSVVCVIEIIEVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALDIDD
DLPTFNSALHLPPALGTQVPGTPPPKYNTLRLERAFSNQLTDTQMLDEL

# Macromolecular_Interacting_Partner_27_Number_of_Residues:
649

# Macromolecular_Interacting_Partner_27_Molecular_Weight:
74271

# Macromolecular_Interacting_Partner_27_Theoretical_pI:
7.54

# Macromolecular_Interacting_Partner_27_GO_Classification:
>>>
Function:  transporter activity
Function:  ion transporter activity
Function:  ion channel activity
Function:  cation channel activity
Function:  sodium channel activity
Function:  amiloride-sensitive sodium channel activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  cation transport
Process:  monovalent inorganic cation transport
Process:  sodium ion transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_27_General_Function:
Not Available

# Macromolecular_Interacting_Partner_27_Specific_Function:
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception

# Macromolecular_Interacting_Partner_27_Pathway:
Not Available

# Macromolecular_Interacting_Partner_27_Reaction:
Not Available

# Macromolecular_Interacting_Partner_27_Pfam_Domain_Function:
PF00858:ASC

# Macromolecular_Interacting_Partner_27_Signals:
None

# Macromolecular_Interacting_Partner_27_Transmembrane_Regions:
56-76
542-562

# Macromolecular_Interacting_Partner_27_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_27_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_27_GenBank_ID_Protein:
1004273

# Macromolecular_Interacting_Partner_27_SwissProt_ID:
SCNNG_HUMAN (P51170)

# Macromolecular_Interacting_Partner_27_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_27_Genecard_id:
SCNN1G

# Macromolecular_Interacting_Partner_27_Geneatlas_id:
SCNN1G

# Macromolecular_Interacting_Partner_27_hgnc_id:
HGNC:10602

# Macromolecular_Interacting_Partner_27_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_27_Subcellular_Location:
Cell membrane; apical cell membrane; multi- pass membrane protein. Note=Apical membrane of epithelial cells

# Macromolecular_Interacting_Partner_27_Gene_Sequence:
>1950 bp
ATGGCCCCCGGGGAGAAGATCAAAGCCAAAATCAAGAAGAATCTGCCCGTGACGGGCCCT
CAGGCGCCGACCATTAAAGAGCTGATGCGGTGGTACTGCCTCAACACCAACACCCATGGC
TGTCGCCGCATCGTGGTGTCCCGCGGCCGTCTGCGCCGCCTCCTCTGGATCGGGTTCACA
CTGACTGCCGTGGCCCTCATCCTCTGGCAGTGCGCCCTCCTCGTCTTCTCCTTCTATACT
GTCTCAGTTTCCATCAAAGTCCACTTCCGGAAGCTGGATTTTCCTGCAGTCACCATCTGC
AACATCAACCCCTACAAGTACAGCACCGTTCGCCACCTTCTAGCTGACTTGGAACAGGAG
ACCAGAGAGGCCCTGAAGTCCCTGTATGGCTTTCCAGAGTCCCGGAAGCGCCGAGAGGCG
GAGTCCTGGAACTCCGTCTCAGAGGGAAAGCAGCCTAGATTCTCCCACCGGATTCCGCTG
CTGATCTTTGATCAGGATGAGAAGGGCAAGGCCAGGGACTTCTTCACAGGGAGGAAGCGG
AAAGTCGGCGGTAGCATCATTCACAAGGCTTCAAATGTCATGCACATCGAGTCCAAGCAA
GTGGTGGGATTCCAACTGTGCTCAAATGACACCTCCGACTGTGCCACCTACACCTTCAGC
TCGGGAATCAATGCCATTCAGGAGTGGTATAAGCTACACTACATGAACATCATGGCACAG
GTGCCTCTGGAGAAGAAAATCAACATGAGCTATTCTGCTGAGGAGCTGCTGGTGACCTGC
TTCTTTGATGGAGTGTCCTGTGATGCCAGGAATTTCACGCTTTTCCACCACCCGATGCAT
GGGAATTGCTATACTTTCAACAACAGAGAAAATGAGACCATTCTCAGCACCTCCATGGGG
GGCAGCGAATATGGGCTGCAAGTCATTTTGTACATAAACGAAGAGGAATACAACCCATTC
CTCGTGTCCTCCACTGGAGCTAAGGTGATCATCCATCGGCAGGATGAGTATCCCTCCGTC
GAAGATGTGGGAACAGAGATTGAGACAACAATGGTCACCTCTATAGGAATGCACCTGACA
GAGTCCTTCAAGCTGAGTGAGCCCTCCAGTCAGTGCACGGAGGGCGGGAGTGACGTGCCA
ATCAGGAACATCTACAACGCTGCCTACTCGCTCCAGATCTGCCTTCATTCATGCTTCCAG
ACAAAGATGGTGGAGAAATGTGGGTGTGCCCAGTACAGCCAGCCTCTACCTCCTGCAGCC
AACTACTGCAACTACCAGCAGCACCCCAACTGGATGTATTGTTACTACCAACTGCATCGA
GCCTTTGTCCAGGAAGAGCTGGGCTGCCAGTCTGTGTGCAAGGAAGCCTGCCGCTTTAAA
GAGTGGACACTAACCACAAGCCTGGCACAATGGCCATCTGTGGTTTCGGAGAAGTGGTTG
CTGCCTGTTCTCACTTGGGACCAAGGCCGGCAAGTAAACAAAAAGCTCAACAAGACAGAC
TTGGCCAAACTCTTGATATTCTACAAAGACCTGAACCAGAGATCCATCATGGAGAGCCCA
GCCAACAGTATTGAGATGCTTCTGTCCAACTTCGGCGGTCAGCTGGGCCTGTGGATGAGC
TGCTCTGTTGTCTGCGTCATCGAGATCATCGAGGTCTTCTTCATTGACTTCTTCTCTATC
ATTGCCCGCCGCCAGTGGCAGAAAGCCAAGGAGTGGTGGGCCTGGAAACAGGCTCCCCCA
TGTCCAGAAGCTCCCCGTAGCCCACAGGGCCAGGACAATCCAGCCCTGGATATAGACGAT
GACCTACCCACTTTCAACTCTGCTTTGCACCTGCCTCCAGCCCTAGGAACCCAAGTGCCC
GGCACACCGCCCCCCAAATACAATACCTTGCGCTTGGAGAGGGCCTTTTCCAACCAGCTC
ACAGATACCCAGATGCTGGATGAGCTCTGA

# Macromolecular_Interacting_Partner_27_GenBank_ID_Gene:
X87160

# Macromolecular_Interacting_Partner_27_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_27_Locus:
16p12

# Macromolecular_Interacting_Partner_27_SNPs:
rs5736; rs5733; rs5738; rs5737; rs5735; rs5723; rs5734; rs16977041; rs4073931; rs4073290; rs7404408; rs4494543; rs5729; rs4073930; rs4073291; rs5728; rs4073289; rs9932505; rs3026; rs5727; rs5730; rs5726; rs9923016; rs5731; rs5732; rs5720; rs5724; rs12934362; rs9922851; rs5722; rs13306657; rs5725; rs5721; rs4302034; rs4328445; rs6497657; rs4260062; rs7200952; rs4516235; rs3922902; rs4247210; rs4486893; rs4335773; rs4281710; rs4470152; rs4499238; rs4341748; rs4297681; rs11643517; rs4967948; rs4347634; rs4309398; rs12708649; rs9941215; rs11649420; rs11643777; rs9931527; rs4407061; rs5740; rs11643416; rs8044686; rs11648257; rs13306653; rs4299163; rs11643449; rs7200183; rs13306654; rs4499239; rs12920681; rs4411498; rs12444767; rs9797088; rs13306665; rs4427805; rs13331086; rs13306659; rs9797083; rs4967991; rs11074553; rs11865345; rs12446988; rs13334616; rs4401050; rs4967949; rs4514682; rs9941210; rs4402571; rs9935983; rs9941128; rs12149898; rs13339277; rs9931080; rs9930846; rs7404738; rs8048419; rs5719; rs12449152; rs5718; rs12449201; rs13306664; rs1126944; rs12447209; rs1126945; rs13306656; rs12149882; rs9926460; rs13306655; rs34120924; rs13306658; rs8043698; rs35147789; rs9924110; rs34281156; rs34993339; rs28534405; rs28525080; rs8063500; rs28414871; rs33931492; rs4132521; rs34606639; rs4967990; rs12930318; rs13335711; rs34293887; rs34396524; rs5816207; rs34549501; rs34689994; rs35214659; rs34477151; rs13335714; rs35249946; rs28377309; rs11642037; rs34977406; rs28674154; rs35779418; rs10532422; rs12927470; rs10716781; rs28571200; rs4620962; rs12924188; rs35750366; rs34518110; rs3922903; rs34749237; rs8060363; rs34665561; rs10532423; rs9630615; rs35192085; rs35065417; rs35090401; rs35869863; rs4620961; rs28524519; rs28565031; rs12919793; rs34514330; rs28521352; rs28440017; rs35242583; rs13335645; rs13335767; rs4405556; rs28608825; rs9937430; rs35352485; rs7498202; rs35864119; rs35288984; rs4132520; rs28514915; rs13332042; rs4967989; rs35523227; rs11309873; rs28368330; rs34258695; rs12149033; rs28586979; rs28415503; rs28504067; rs34802827; rs9938519; rs11643078; rs34243485; rs4511539; rs4577093; rs4967986; rs7202243; rs7206022; rs7500507; rs9922642; rs9927161; rs9928041

# Macromolecular_Interacting_Partner_27_General_References:
7490094; 7762608; 8824247; 7550319; 9169421; 12167593; 10404817; 10391210

# Macromolecular_Interacting_Partner_27_References:
16204229; 16954160

# Macromolecular_Interacting_Partner_28_ID:
8202

# Macromolecular_Interacting_Partner_28_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_28_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_28_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_28_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_28_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_28_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_28_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_28_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_28_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_28_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_28_Pathway:
Not Available

# Macromolecular_Interacting_Partner_28_Reaction:
Not Available

# Macromolecular_Interacting_Partner_28_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_28_Signals:
None

# Macromolecular_Interacting_Partner_28_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_28_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_28_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_28_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_28_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_28_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_28_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_28_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_28_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_28_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_28_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_28_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_28_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_28_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_28_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_28_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_28_Locus:
10q22

# Macromolecular_Interacting_Partner_28_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_28_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_28_References:
15511634; 15529592; 15608836; 15834444

# Macromolecular_Interacting_Partner_29_ID:
8446

# Macromolecular_Interacting_Partner_29_Name:
Prostasin precursor

# Macromolecular_Interacting_Partner_29_Synonyms:
Serine protease 8[Contains: Prostasin light chain; Prostasin heavy chain]

# Macromolecular_Interacting_Partner_29_Gene_Name:
PRSS8

# Macromolecular_Interacting_Partner_29_Protein_Sequence:
>Prostasin precursor
MAQKGVLGPGQLGAVAILLYLGLLRSGTGAEGAEAPCGVAPQARITGGSSAVAGQWPWQV
SITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDI
IPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSV
SLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGG
PLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRVVPQTQESQ
PDSNLCGSHLAFSSAPAQGLLRPILFLPLGLALGLLSPWLSEH

# Macromolecular_Interacting_Partner_29_Number_of_Residues:
343

# Macromolecular_Interacting_Partner_29_Molecular_Weight:
36432

# Macromolecular_Interacting_Partner_29_Theoretical_pI:
5.72

# Macromolecular_Interacting_Partner_29_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_29_General_Function:
Not Available

# Macromolecular_Interacting_Partner_29_Specific_Function:
Possesses a trypsin-like cleavage specificity

# Macromolecular_Interacting_Partner_29_Pathway:
Not Available

# Macromolecular_Interacting_Partner_29_Reaction:
Not Available

# Macromolecular_Interacting_Partner_29_Pfam_Domain_Function:
PF00089:Trypsin

# Macromolecular_Interacting_Partner_29_Signals:
1-29

# Macromolecular_Interacting_Partner_29_Transmembrane_Regions:
320-340

# Macromolecular_Interacting_Partner_29_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_29_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_29_GenBank_ID_Protein:
862305

# Macromolecular_Interacting_Partner_29_SwissProt_ID:
PRSS8_HUMAN (Q16651)

# Macromolecular_Interacting_Partner_29_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_29_Genecard_id:
PRSS8

# Macromolecular_Interacting_Partner_29_Geneatlas_id:
PRSS8

# Macromolecular_Interacting_Partner_29_hgnc_id:
HGNC:9491

# Macromolecular_Interacting_Partner_29_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_29_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_29_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_29_Subcellular_Location:
Prostasin:Cell membrane; single-pass membrane protein. Prostasin light chain:Secreted protein; extracellular space. Prostasin heavy chain:Secreted protein; extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus

# Macromolecular_Interacting_Partner_29_Gene_Sequence:
>1032 bp
ATGGCCCAGAAGGGGGTCCTGGGGCCTGGGCAGCTGGGGGCTGTGGCCATTCTGCTCTAT
CTTGGATTACTCCGGTCGGGGACAGGAGCGGAAGGGGCAGAAGCTCCCTGCGGTGTGGCC
CCCCAAGCACGCATCACAGGTGGCAGCAGTGCAGTCGCCGGTCAGTGGCCCTGGCAGGTC
AGCATCACCTATGAAGGCGTCCATGTGTGTGGTGGCTCTCTCGTGTCTGAGCAGTGGGTG
CTGTCAGCTGCTCACTGCTTCCCCAGCGAGCACCACAAGGAAGCCTATGAGGTCAAGCTG
GGGGCCCACCAGCTAGACTCCTACTCCGAGGACGCCAAGGTCAGCACCCTGAAGGACATC
ATCCCCCACCCCAGCTACCTCCAGGAGGGCTCCCAGGGCGACATTGCACTCCTCCAACTC
AGCAGACCCATCACCTTCTCCCGCTACATCCGGCCCATCTGCCTCCCTGCAGCCAACGCC
TCCTTCCCCAACGGCCTCCACTGCACTGTCACTGGCTGGGGTCATGTGGCCCCCTCAGTG
AGCCTCCTGACGCCCAAGCCACTGCAGCAACTCGAGGTGCCTCTGATCAGTCGTGAGACG
TGTAACTGCCTGTACAACATCGACGCCAAGCCTGAGGAGCCGCACTTTGTCCAAGAGGAC
ATGGTGTGTGCTGGCTATGTGGAGGGGGGCAAGGACGCCTGCCAGGGTGACTCTGGGGGC
CCACTCTCCTGCCCTGTGGAGGGTCTCTGGTACCTGACGGGCATTGTGAGCTGGGGAGAT
GCCTGTGGGGCCCGCAACAGGCCTGGTGTGTACACTCTGGCCTCCAGCTATGCCTCCTGG
ATCCAAAGCAAGGTGACAGAACTCCAGCCTCGTGTGGTGCCCCAAACCCAGGAGTCCCAG
CCCGACAGCAACCTCTGTGGCAGCCACCTGGCCTTCAGCTCTGCCCCAGCCCAGGGCTTG
CTGAGGCCCATCCTTTTCCTGCCTCTGGGCCTGGCTCTGGGCCTCCTCTCCCCATGGCTC
AGCGAGCACTGA

# Macromolecular_Interacting_Partner_29_GenBank_ID_Gene:
L41351

# Macromolecular_Interacting_Partner_29_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_29_Locus:
16p11.2

# Macromolecular_Interacting_Partner_29_SNPs:
rs12597511; rs2855475; rs9972727; rs11645814; rs11558744; rs8049043; rs2550054; rs2550050; rs2855476; rs2550051; rs2550049; rs2550052; rs2855477; rs2550053; rs2550048; rs1047488; rs1060506; rs1549293; rs1549294; rs1549295; rs1549299; rs1549300; rs2550055; rs2550056; rs2855478; rs2855480; rs35208368; rs35319087; rs752148; rs8053474; rs889548; rs9936329

# Macromolecular_Interacting_Partner_29_General_References:
7768952; 8034638

# Macromolecular_Interacting_Partner_29_References:
15549446; 16941024

# Macromolecular_Interacting_Partner_30_ID:
7767

# Macromolecular_Interacting_Partner_30_Name:
E3 ubiquitin-protein ligase NEDD4-like protein

# Macromolecular_Interacting_Partner_30_Synonyms:
Nedd4-2; NEDD4.2

# Macromolecular_Interacting_Partner_30_Gene_Name:
NEDD4L

# Macromolecular_Interacting_Partner_30_Protein_Sequence:
>E3 ubiquitinprotein ligase NEDD4like protein
MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELAL
VQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDP
TMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSN
DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQI
NQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGS
RTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPA
GRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQL
AEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSP
QPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKT
SLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQK
YDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDY
GGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLA
VFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEE
NFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLI
KIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQ
FVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREK
LLMAVENAQGFEGVD

# Macromolecular_Interacting_Partner_30_Number_of_Residues:
975

# Macromolecular_Interacting_Partner_30_Molecular_Weight:
111933

# Macromolecular_Interacting_Partner_30_Theoretical_pI:
5.60

# Macromolecular_Interacting_Partner_30_GO_Classification:
>>>
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  acid-amino acid ligase activity
Function:  ubiquitin-protein ligase activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  cell
Component:  intracellular

# Macromolecular_Interacting_Partner_30_General_Function:
Not Available

# Macromolecular_Interacting_Partner_30_Specific_Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK

# Macromolecular_Interacting_Partner_30_Pathway:
Not Available

# Macromolecular_Interacting_Partner_30_Reaction:
Not Available

# Macromolecular_Interacting_Partner_30_Pfam_Domain_Function:
PF00168:C2;
PF00632:HECT;
PF00397:WW

# Macromolecular_Interacting_Partner_30_Signals:
None

# Macromolecular_Interacting_Partner_30_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_30_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_30_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_30_GenBank_ID_Protein:
12003318

# Macromolecular_Interacting_Partner_30_SwissProt_ID:
NED4L_HUMAN (Q96PU5)

# Macromolecular_Interacting_Partner_30_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_30_Genecard_id:
NEDD4L

# Macromolecular_Interacting_Partner_30_Geneatlas_id:
NEDD4L

# Macromolecular_Interacting_Partner_30_hgnc_id:
HGNC:7728

# Macromolecular_Interacting_Partner_30_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_30_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_30_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_30_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_30_Gene_Sequence:
>2565 bp
ATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGA
GTTAAGGGATTTTTGCGATTGAAAATGGCCTATATGCCAAAAAATGGAGGTCAAGATGAA
GAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATGAC
TCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAA
AAAGTGGACAATTTAGGCCGAACTTACTATGTCAACCACAACAACCGGACCACTCAGTGG
CACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATCAAC
CAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCC
GAGCCCTCGGAGGGCGGGGATGTCCCCGAGCCTTGGGAGACCATTTCAGAGGAAGTGAAT
ATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTCGG
ACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCC
AATGGGGAACAGTTCAGCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTGAGGTCATGC
AGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCCAGTGCCCCAGCTGGG
AGAGCGCGTTCATCAACTGTCACGGGTGGTGAGGAACCAACGCCATCAGTGGCCTATGTA
CATACCACGCCGGGTCTGCCTTCAGGCTGGGAAGAAAGAAAAGATGCTAAGGGGCGCACA
TACTATGTCAATCATAACAATCGAACCACAACTTGGACTCGACCTATCATGCAGCTTGCA
GAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATC
CGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCC
AAGGACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAGTCCCCACAG
CCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCC
GGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAG
ACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCAAAGACATCT
TTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGAT
GGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTG
CAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAATAT
GACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAA
CTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCA
GATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTTGACTATGGG
GGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGC
CTCTTTGAGTACTCTGCCACGGACAACTACACCCTTCAGATCAACCCTAATTCAGGCCTC
TGTAATGAGGATCATTTGTCCTACTTCACTTTTATTGGAAGAGTTGCTGGTCTGGCCGTA
TTTCATGGGAAGCTCTTAGATGGTTTCTTCATTAGACCATTTTACAAGATGATGTTGGGA
AAGCAGATAACCCTGAATGACATGGAATCTGTGGATAGTGAATATTACAACTCTTTGAAA
TGGATCCTGGAGAATGACCCTACTGAGCTGGACCTCATGTTCTGCATAGACGAAGAAAAC
TTTGGACAGACATATCAAGTGGATTTGAAGCCCAATGGGTCAGAAATAATGGTCACAAAT
GAAAACAAAAGGGAATATATCGACTTAGTCATCCAGTGGAGATTTGTGAACAGGGTCCAG
AAGCAGATGAACGCATTCTTGGAGGGATTCACAGAACTACTTCCTATTGATTTGATTAAA
ATTTTTGATGAAAATGAGCTGGAGTTGCTCATGTGCGGCCTCGGTGATGTGGATGTGAAT
GACTGGAGACAGCATTCTATTTACAAGAACGGCTACTGCCCAAACCACCCCGTCATTCAG
TGGTTCTGGAAGGCTGTGCTACTCATGGACGCCGAAAAGCGTATCCGGTTACTGCAGTTT
GTCACAGGGACATCGCGAGTACCTATGAATGGATTTGCCGAACTTTATGGTTCCAATGGT
CCTCAGCTGTTTACAATAGAGCAATGGGGCAGTCCTGAGAAACTGCCCAGAGCTCACACA
TGCTTTAATCGCCTTGACTTACCTCCATATGAAACCTTTGAAGATTTACGAGAGAAACTT
CTCATGGCCGTGGAAAATGCTCAAGGATTTGAAGGGGTGGATTAA

# Macromolecular_Interacting_Partner_30_GenBank_ID_Gene:
AF210730

# Macromolecular_Interacting_Partner_30_Chromosome_Location:
Chromosome:18

# Macromolecular_Interacting_Partner_30_Locus:
18q21

# Macromolecular_Interacting_Partner_30_SNPs:
rs4149616; rs158862; rs292447; rs1942565; rs497018; rs501370; rs1787777; rs499661; rs158865; rs734779; rs554192; rs2288772; rs569125; rs566032; rs158855; rs2075405; rs2288775; rs158866; rs292455; rs553525; rs504368; rs1787775; rs1787776; rs292449; rs1626076; rs486285; rs1787771; rs479131; rs158868; rs1864921; rs473776; rs483540; rs292457; rs2288774; rs472847; rs292450; rs292444; rs1626887; rs2043265; rs473727; rs565757; rs7240482; rs6566959; rs8094434; rs192659; rs8092749; rs8088164; rs8093462; rs4940665; rs8093302; rs8097018; rs8086848; rs158867; rs4058287; rs6566946; rs471143; rs4941367; rs9944964; rs522155; rs4941377; rs7237429; rs8092871; rs11152059; rs10871753; rs9953409; rs8086835; rs2075403; rs8098126; rs8087052; rs894798; rs8089678; rs4941384; rs4499324; rs6566949; rs571794; rs10513914; rs4340401; rs2105715; rs1942564; rs9957202; rs1005015; rs292451; rs4940387; rs9960278; rs1893480; rs4641835; rs4286186; rs7236804; rs4461163; rs4941382; rs512099; rs4302128; rs4940646; rs547560; rs752124; rs4600541; rs8094453; rs11660589; rs12458921; rs4940679; rs4941366; rs8092556; rs581326; rs8089511; rs8083963; rs9950996; rs9950141; rs1620958; rs8092866; rs1977948; rs4940385; rs9963986; rs4149592; rs7238511; rs1975145; rs9962071; rs1001685; rs8098336; rs3902163; rs4058294; rs4378687; rs4940659; rs4940661; rs6566953; rs7244444; rs4997300; rs485027; rs4941364; rs3865419; rs2075404; rs8090154; rs559840; rs495587; rs4371241; rs4149598; rs6566928; rs4375742; rs7506383; rs9952789; rs1942562; rs2075407; rs4941304; rs574218; rs9949716; rs7229644; rs8084325; rs8087657; rs533502; rs3865420; rs7235554; rs4058288; rs4940671; rs9950709; rs549595; rs4941349; rs12455173; rs8083516; rs7228980; rs1787778; rs579709; rs7239980; rs4419136; rs9948501; rs158856; rs3865414; rs894799; rs9675944; rs6566931; rs2075408; rs2075409; rs1620068; rs497254; rs2586979; rs8083578; rs7230600; rs8085125; rs7242929; rs7243899; rs10871754; rs7236597; rs9957844; rs11152062; rs11661447; rs9955824; rs7232823; rs504904; rs507008; rs476085; rs8098033; rs1573390; rs158857; rs4349234; rs4149601; rs535188; rs11660749; rs12457509; rs7231665; rs7242119; rs8085143; rs4329992; rs6566965; rs4149595; rs7229657; rs8093141; rs1942563; rs4149591; rs6566942; rs4940386; rs4941310; rs563435; rs564442; rs2075406; rs12605388; rs7241969; rs12456898; rs11152060; rs581332; rs4640267; rs4940651; rs7241218; rs571759; rs6566957; rs4940663; rs480230; rs4245310; rs471948; rs538257; rs6566938; rs6566939; rs4528665; rs5005280; rs504098; rs292445; rs7233436; rs563283; rs4940635; rs9962106; rs4058295; rs4941388; rs4940669; rs4149597; rs7231752; rs520210; rs4605249; rs11152065; rs3865415; rs8093609; rs10513913; rs4941348; rs7240603; rs9947545; rs7232273; rs500733; rs490271; rs6566955; rs3744865; rs4940667; rs6566964; rs8086364; rs4591235; rs158861; rs292456; rs4940660; rs9956458; rs11664018; rs9947040; rs182383; rs150385; rs7233294; rs4941378; rs3865418; rs12454098; rs7243662; rs12458971; rs10513916; rs9961411; rs4149605; rs1453082; rs12604234; rs7242486; rs564975; rs1573391; rs12605506; rs1551247; rs4940675; rs894800; rs17232701; rs9953918; rs9963876; rs17064344; rs17064502; rs8091354; rs7243360; rs9959337; rs6566954; rs8084983; rs9966466; rs540101; rs503703; rs520895; rs1008899; rs8092384; rs561126; rs7231823; rs17064338; rs17064589; rs6566940; rs9944723; rs8083107; rs4941312; rs17806239; rs17064925; rs7229171; rs4941389; rs549476; rs17235322; rs17064700; rs7242150; rs12604359; rs1943995; rs7243904; rs6566952; rs569176; rs573880; rs12454023; rs13381636; rs13381932; rs12604734; rs527251; rs17806462; rs576451; rs4149608; rs17833989; rs8085049; rs292443; rs6566933; rs17693592; rs17064800; rs4941375; rs1675; rs8097619; rs4383236; rs10513915; rs10513912; rs963421; rs12457194; rs8088506; rs12967110; rs9949561; rs6566944; rs12458881; rs8082759; rs9959499; rs7239275; rs11874316; rs11662707; rs158858; rs9954721; rs8087212; rs1624292; rs6566958; rs4941380; rs12608075; rs524815; rs13381214; rs7232633; rs513029; rs1975144; rs486997; rs8096809; rs158869; rs7242743; rs17064695; rs7234847; rs559046; rs6566956; rs6566937; rs17693882; rs17064643; rs11152070; rs1562029; rs12605282; rs13380982; rs11661951; rs4149607; rs11663227; rs7235620; rs17693689; rs574890; rs4358024; rs6566961; rs2304021; rs1573389; rs9951962; rs566343; rs17064729; rs9947412; rs9949342; rs11874572; rs9944842; rs4940650; rs11660199; rs7238687; rs17064577; rs4149589; rs4941347; rs4941379; rs536545; rs12606138; rs11664614; rs7236126; rs2051306; rs550737; rs6566951; rs12965133; rs3816005; rs13381620; rs6566935; rs552456; rs11664416; rs12051934; rs10513911; rs11663290; rs536222; rs11152064; rs11662225; rs292453; rs292448; rs9954295; rs7241822; rs1977947; rs2586982; rs878396; rs12455563; rs525839; rs12454199; rs9959537; rs3809969; rs4257288; rs8088201; rs1943994; rs732796; rs10503022; rs17064591; rs1573388; rs522864; rs4941383; rs7231348; rs513111; rs4149593; rs577837; rs12606637; rs6566941; rs7238829; rs6566934; rs12953449; rs12956511; rs9945040; rs9954157; rs482805; rs9965250; rs11152069; rs9955907; rs3852853; rs8094327; rs12456509; rs17064331; rs8091185; rs12373506; rs12457076; rs9964793; rs9948710; rs506784; rs7242074; rs529478; rs7230356; rs474743; rs6566943; rs9960869; rs7227501; rs11663936; rs4941332; rs4941373; rs9965270; rs8082897; rs12605327; rs7243164; rs8090150; rs10503020; rs11664664; rs559475; rs530899; rs9956206; rs4149609; rs8087044; rs17064669; rs4940677; rs4940662; rs9950627; rs11663320; rs11662999; rs4940647; rs2304020; rs502450; rs17064340; rs513563; rs8089173; rs1672; rs10439056; rs12960965; rs17064520; rs495437; rs557238; rs11660397; rs17064916; rs9965182; rs4940678; rs543347; rs3809967; rs571730; rs4941386; rs11152066; rs7244473; rs560894; rs6566962; rs17064378; rs4455056; rs7235668; rs11663307; rs572064; rs7235727; rs7235598; rs7240964; rs17064918; rs9989611; rs2586983; rs7239316; rs7232059; rs12959070; rs2083861; rs4941339; rs8094889; rs17064747; rs8096096; rs17064854; rs526730; rs7241583; rs8085142; rs8089275; rs4072562; rs9285377; rs9946135; rs2602167; rs4940657; rs12968965; rs7233421; rs7242102; rs576416; rs7229083; rs12456657; rs8091333; rs17064830; rs4940643; rs7243384; rs9807396; rs12605830; rs571570; rs12327065; rs8085894; rs12966139; rs531896; rs17064859; rs9959036; rs8094298; rs9957225; rs12961713; rs565576; rs10871751; rs7233095; rs7230539; rs17760597; rs541427; rs11874311; rs12955136; rs9989576; rs473197; rs4149594; rs17064913; rs4941351; rs559636; rs11152063; rs2277718; rs9989592; rs1663041; rs10503021; rs17064342; rs8091196; rs17231892; rs17064483; rs17064879; rs17693634; rs150384; rs8084648; rs531104; rs523986; rs6566929; rs12963674; rs158860; rs12963630; rs11874278; rs9989620; rs1864920; rs12958393; rs503310; rs17064888; rs17064946; rs4149610; rs12964776; rs17064950; rs10515976; rs17064328; rs17756323; rs10439057; rs17064944; rs12326982; rs8094712; rs4940672; rs8090870; rs17064625; rs532894; rs17833707; rs7236464; rs7227056; rs17064654; rs17808190; rs557036; rs12326405; rs4941333; rs9965998; rs9957740; rs11660748; rs17833671; rs12458981; rs8092126; rs7407205; rs8095085; rs12455559; rs17064939; rs12456846; rs8088889; rs17064735; rs477257; rs1787773; rs4941374; rs11665627; rs9954083; rs17064741; rs6566963; rs158864; rs8088115; rs17064935; rs17064952; rs17760402; rs11665546; rs7242397; rs17806115; rs9965313; rs7236010; rs2000855; rs9953645; rs8088474; rs2440193; rs642085; rs4940670; rs17064863; rs12970001; rs12954064; rs580471; rs7244907; rs17755337; rs1977945; rs12955484; rs7236132; rs17064855; rs1893750; rs12954457; rs503073; rs1977946; rs17064941; rs17755321; rs516354; rs17833599; rs17064948; rs11876334; rs508623; rs7235976; rs17693949; rs8092552; rs8086947; rs9807169; rs9950346; rs17064750; rs8097251; rs17064883; rs9807605; rs7239483; rs12957255; rs6566926; rs17693622; rs578084; rs11876767; rs12456045; rs6566930; rs8093023; rs7234852; rs4149603; rs9960929; rs486117; rs8095089; rs7231040; rs8096864; rs7243469; rs9748835; rs8085111; rs8088743; rs12606685; rs17064650; rs190010; rs896750; rs17064757; rs9989619; rs9319927; rs17064780; rs17064891; rs2288773; rs17064701; rs9955628; rs4940674; rs7239274; rs10083983; rs4941335; rs12967469; rs7243326; rs17064667; rs574626; rs12051999; rs8086905; rs10163777; rs9963992; rs9959043; rs17693604; rs12960902; rs9956242; rs11665115; rs12052001; rs9958896; rs7228829; rs7242262; rs4149614; rs12150766; rs11872836; rs8084158; rs4355014; rs9955426; rs9961191; rs502163; rs8099661; rs17064593; rs17808061; rs569277; rs7236193; rs292452; rs4941372; rs529445; rs8083106; rs8097163; rs9952299; rs17235782; rs17064505; rs11665288; rs2319609; rs12455904; rs4621061; rs476420; rs12456994; rs17693701; rs12963185; rs566087; rs480754; rs45448; rs158863; rs17064345; rs12454583; rs1787774; rs17062443; rs4149611; rs7243373; rs7227636; rs10163714; rs12960370; rs12456838; rs8094065; rs17064936; rs4340402; rs4072561; rs7226681; rs559951; rs6566927; rs12958178; rs10460144; rs17064503; rs9319926; rs9948817; rs8092805; rs17064596; rs950939; rs6650727; rs17807652; rs17064621; rs12456835; rs17064904; rs17233743; rs11659751; rs9807168; rs7240364; rs4381674; rs17064679; rs48000; rs12150702; rs7239848; rs11872262; rs9636032; rs7227001; rs17756149; rs17808031; rs4940642; rs17064706; rs7235250; rs8092818; rs6566945; rs2849214; rs7230985; rs17064791; rs11152056; rs646509; rs12968145; rs34792654; rs11152067; rs1943993; rs35265055; rs34029164; rs1044493; rs11433892; rs34842701; rs11353228; rs34594423; rs10660224; rs34040455; rs567226; rs36022323; rs1670326; rs12456990; rs13381917; rs11434919; rs4940668; rs497038; rs10706255; rs35819264; rs35066373; rs12963504; rs1031122; rs10666589; rs12956570; rs33923139; rs11376555; rs35550911; rs34227801; rs35525814; rs35418156; rs34639145; rs9947352; rs35172365; rs499500; rs9807785; rs11377224; rs34546456; rs176754; rs4149615; rs5825267; rs9989621; rs4149602; rs1285352; rs34658652; rs34622462; rs28638370; rs576109; rs8087059; rs188351; rs35030405; rs12604906; rs12959306; rs548320; rs7231889; rs35416657; rs28441489; rs7230229; rs9952515; rs35273931; rs507854; rs11443994; rs35953494; rs1663043; rs34280771; rs11439150; rs1787770; rs7232429; rs292454; rs11269772; rs34928650; rs7234313; rs12326838; rs2920494; rs8093767; rs35734390; rs5825265; rs11350356; rs5825272; rs8083748; rs693864; rs474911; rs34124678; rs561971; rs12970711; rs28462128; rs513435; rs582101; rs11665621; rs12966278; rs7235498; rs11343860; rs12604462; rs492691; rs11452407; rs11363730; rs562722; rs1670334; rs34164994; rs35976964; rs565257; rs191907; rs7240430; rs35812554; rs12968897; rs1670329; rs549531; rs34042427; rs8092006; rs12608173; rs36112838; rs34644275; rs36218819; rs12954778; rs9960340; rs35310744; rs34001228; rs35222707; rs190005; rs34381915; rs11875074; rs693750; rs34067523; rs11428475; rs4149600; rs9949110; rs34208996; rs34406608; rs35603239; rs2053963; rs34525242; rs8095660; rs35766513; rs575011; rs12970622; rs492648; rs13380918; rs5825260; rs34431035; rs1300136; rs33951095; rs1670327; rs11443274; rs11152068; rs11456666; rs503475; rs6566932; rs474322; rs35378668; rs12954787; rs8099132; rs8086810; rs28567712; rs35192183; rs10717406; rs475604; rs536970; rs9957282; rs11399898; rs4149612; rs527013; rs4940388; rs8093734; rs34965383; rs292441; rs10665833; rs34353138; rs35632443; rs176756; rs504286; rs176752; rs36023671; rs560824; rs520387; rs35314135; rs499820; rs506146; rs41537144; rs474924; rs13313677; rs35320308; rs9965372; rs505218; rs520132; rs5825274; rs7504229; rs558195; rs34259379; rs35111781; rs28625940; rs35683540; rs28532065; rs11364816; rs11152057; rs569264; rs28678259; rs12966283; rs191911; rs35003997; rs4941336; rs34559916; rs28568337; rs35246431; rs186035; rs1670336; rs479309; rs11288765; rs12960786; rs35001999; rs4424984; rs7227763; rs10649020; rs12960355; rs7227653; rs511342; rs1815885; rs34145756; rs35431664; rs1299853; rs566322; rs11280693; rs35755247; rs547603; rs9963750; rs12960340; rs11663373; rs12955992; rs35706122; rs11285323; rs10555499; rs13381995; rs503421; rs35132150; rs28393967; rs35025153; rs35044852; rs8086884; rs28644383; rs591608; rs533677; rs28435764; rs35509600; rs7232891; rs8098066; rs34336961; rs9319925; rs12966385; rs17064375; rs5825261; rs4940676; rs501313; rs520574; rs512414; rs5825269; rs34251792; rs17694201; rs11365674; rs35813484; rs544171; rs622598; rs11662229; rs1299367; rs9949775; rs549037; rs35525973; rs35757123; rs9954538; rs183304; rs35369118; rs35718137; rs191914; rs9965187; rs35874222; rs10538442; rs33993931; rs33930298; rs1539933; rs188350; rs33986394; rs550359; rs502437; rs34879628; rs1815886; rs28651872; rs524009; rs7230210; rs36080658; rs186033; rs33973111; rs182376; rs11344086; rs11878005; rs577337; rs172377; rs28683754; rs562021; rs538068; rs36036892; rs11152061; rs7228701; rs1298965; rs560761; rs34581009; rs35459784; rs36232990; rs9952093; rs11318354; rs506894; rs4335844; rs539938; rs533534; rs948945; rs33978271; rs190009; rs538730; rs35546653; rs7233451; rs35888707; rs34675886; rs8088074; rs28497993; rs34588316; rs11439394; rs497045; rs35193154; rs536362; rs36018036; rs35661011; rs28602712; rs608187; rs545086; rs28531887; rs33945462; rs8085301; rs12956423; rs487988; rs34993486; rs12962319; rs7230471; rs571843; rs35884073; rs551232; rs5825258; rs35834464; rs556313; rs35820126; rs35259439; rs34711494; rs12960361; rs34667085; rs560128; rs34369490; rs8093026; rs539500; rs5825263; rs34531441; rs7227871; rs10709413; rs9961344; rs504165; rs9966645; rs1145495; rs12961882; rs35796689; rs478249; rs7235725; rs1670331; rs580617; rs1787768; rs592444; rs10550828; rs292446; rs33941026; rs8093704; rs36074660; rs35095232; rs34159753; rs34296748; rs7233556; rs549472; rs35566593; rs34851743; rs34944629; rs35227822; rs628548; rs34372145; rs11364421; rs13339710; rs11322037; rs36048114; rs35457085; rs34120175; rs4941387; rs34978113; rs3865416; rs1297602; rs4149590; rs35084909; rs12955309; rs34935259; rs11268037; rs34033334; rs479726; rs550387; rs1970680; rs8095185; rs12326435; rs34307554; rs35614158; rs34147448; rs502430; rs7231139; rs474876; rs13381234; rs34517636; rs2167773; rs7233282; rs578722; rs2602161; rs1145493; rs34215861; rs11411331; rs36069538; rs35417180; rs1299534; rs536886; rs538092; rs28604973; rs7241638; rs1014633; rs34261657; rs191909; rs553916; rs487990; rs28680199; rs547297; rs35157719; rs10543922; rs190007; rs2586981; rs507688; rs36023807; rs609673; rs11364817; rs28549255; rs9955454; rs10164048; rs9945608; rs525612; rs12326452; rs9989622; rs34610139; rs35541695; rs34907503; rs504620; rs35971879; rs523321; rs5825275; rs35822067; rs12962018; rs581535; rs8084828; rs2920495; rs33977375; rs34387954; rs576252; rs34375334; rs478292; rs34784281; rs553885; rs5825264; rs667318; rs556828; rs7229050; rs33917490; rs491763; rs12971090; rs500583; rs9954318; rs10583562; rs150377; rs12965336; rs183305; rs555056; rs538105; rs34786093; rs35307691; rs35699329; rs566068; rs619733; rs35422628; rs529884; rs496477; rs33959315; rs9966824; rs498170; rs8092332; rs575337; rs10666590; rs5825257; rs12960363; rs10579186; rs8098960; rs11664507; rs34623575; rs502552; rs35195874; rs28426970; rs12966722; rs654935; rs491642; rs176755; rs2083862; rs12964041; rs526241; rs34601020; rs473740; rs34748671; rs35777699; rs36216804; rs529732; rs580727; rs35464364; rs539406; rs12954208; rs34597926; rs1299535; rs34407841; rs34853900; rs531975; rs494487; rs12961475; rs1670328; rs35807300; rs191910; rs523721; rs33931467; rs476351; rs4133478; rs496964; rs34075636; rs34488547; rs35540189; rs2849215; rs34697992; rs34046823; rs5825266; rs28721559; rs9653063; rs575946; rs3217371; rs1663045; rs35814739; rs8099743; rs9945429; rs11876361; rs35568292; rs517792; rs1663044; rs35634926; rs4940673; rs12970577; rs1670332; rs36056251; rs1670333; rs35881225; rs577353; rs12326249; rs176751; rs34222607; rs11659445; rs35048528; rs8087287; rs11314149; rs7242748; rs972106; rs7234292; rs529727; rs12608188; rs28665715; rs10664303; rs7236941; rs574490; rs9963386; rs34065701; rs34444130; rs35064565; rs12961340; rs35909789; rs507056; rs536747; rs539898; rs28452174; rs8092029; rs520348; rs1663042; rs8084442; rs28542880; rs557294; rs35427047; rs36055525; rs191912; rs505924; rs11444453; rs35045737; rs7230909; rs11659306; rs34308286; rs1670335; rs7229995; rs573785; rs12966582; rs553053; rs11442160; rs35114957; rs577183; rs28591615; rs35289750; rs512163; rs503239; rs562114; rs35532882; rs479865; rs10617839; rs183303; rs513849; rs488121; rs495921; rs9965831; rs36037019; rs4444412; rs10682442; rs34380629; rs11452302; rs483338; rs34103175; rs7239419; rs10641509; rs35567822; rs33913403; rs35371720; rs572794; rs188363; rs10535926; rs693528; rs7231855; rs35792725; rs176753; rs36091358; rs9958807; rs10541382; rs11378477; rs1654078; rs548502; rs11416348; rs34190027; rs35664268; rs623070; rs34220312; rs510542; rs35629078; rs5825268; rs12970589; rs33964439; rs559191; rs34027490; rs2304022; rs11399897; rs28804164; rs35937828; rs34668647; rs292442; rs35370991; rs35483920; rs1300135; rs4149613; rs33942672; rs172376; rs10673353; rs36109290; rs569974; rs491420; rs11394157; rs9963330; rs4940664; rs9807582; rs502134; rs35215280; rs565391; rs34137186; rs4245308; rs35077870; rs493621; rs10600171; rs557558; rs12162212; rs210422; rs3063155; rs12961145; rs7228264; rs471506; rs9953600; rs34947066; rs35625462; rs13381029; rs34787512; rs158859; rs7231470; rs12955022; rs8082726; rs4563113; rs11283530; rs186036; rs12150716; rs7227694; rs28584294; rs533674; rs35976441; rs4542741; rs529085; rs499522; rs499679; rs505202; rs182377; rs35351642; rs9958604; rs12970716; rs580239; rs482446; rs28549042; rs4941346; rs35024815; rs9789135; rs689200; rs34500074; rs11336440; rs34192374; rs550451; rs4149599; rs34979688; rs8084079; rs4941381; rs34257024; rs570737; rs10601865; rs2586980; rs9951941; rs524446; rs505828; rs534031; rs526652; rs494055; rs12104006; rs34671195; rs5825271; rs33911620; rs476984; rs34644761; rs5013567; rs11877770; rs36095321; rs519603; rs608189; rs7232726; rs566112; rs527586; rs35472016; rs34561920; rs34769922; rs35984985; rs12954780; rs35885246; rs577703; rs191908; rs7232756; rs512415; rs11425814; rs667365; rs568029; rs532485; rs34479059; rs1285353; rs549738; rs528329; rs17833779; rs35987145; rs11283426; rs11659354; rs548377; rs12604985; rs11437559; rs34769745; rs11405559; rs36121035; rs532679; rs11877731; rs12967665; rs12955988; rs4941376; rs11275898; rs9960771; rs34643985; rs579391; rs7242530; rs2602162; rs4149606; rs477350; rs17234871; rs34446805; rs578120; rs3865417; rs1789247; rs10600170; rs191913; rs693652; rs10578136; rs182375; rs35757799; rs473085; rs533315; rs34841803; rs7232411; rs576284; rs2440192; rs12964991; rs34217101; rs35334839; rs521877; rs7230023; rs3898787; rs494103; rs35125632; rs36035570; rs190006; rs622129; rs525969; rs186034; rs17807227; rs34607377; rs35888502; rs35874179; rs548990; rs549108; rs9956746; rs28465303; rs7243777; rs12966489; rs10164107; rs557341; rs34786147; rs28647359; rs34160501; rs35242976; rs508093; rs172390; rs36048037; rs1970681; rs2288776; rs5825273; rs191906; rs11296007; rs525453; rs28484910; rs34276141; rs12966466; rs543150; rs34960405; rs9964853; rs537955; rs169751; rs1294079; rs12959491; rs7235890; rs7235848; rs8093336; rs12970284; rs34905417; rs10547797; rs36046684; rs35848920; rs36023848; rs1944804; rs538981; rs34058561; rs2586978; rs35935231; rs9957736; rs536956; rs609727; rs580763; rs9989615; rs35453856; rs5825259; rs525733; rs506252; rs35641671; rs529627; rs34406078; rs562017; rs623490; rs36121232; rs28478239; rs568053; rs33980143; rs580012; rs12961884; rs35798011; rs34279885; rs10538443; rs1670330; rs5825262; rs4149604; rs35999182; rs1145496; rs474396; rs11664888; rs34591604; rs34750525; rs36058093; rs34204397; rs514576; rs573731; rs35844936; rs12955303; rs35636113; rs1787769; rs34466213; rs531534; rs503253; rs1299366; rs35716921; rs534158; rs8096649; rs9954077; rs35138154; rs11152055; rs11398377; rs4496245; rs9953520; rs35545013; rs34088423; rs12454716; rs12955342; rs12957320; rs13381441; rs13381443; rs13381672; rs17064956; rs17756406; rs1893859; rs3760545; rs3897657; rs4383235; rs4485450; rs4488539; rs4499325; rs4583344; rs4586538; rs4940680; rs4940681; rs4940682; rs4940683; rs4940685; rs6566922; rs6566966; rs7227349; rs7228326; rs7243190; rs7243671; rs7243958; rs7244027; rs7245352; rs8086017; rs9958167; rs9962179; rs9965842

# Macromolecular_Interacting_Partner_30_General_References:
11840194; 14556380; 14615060; 9455477; 11046148

# Macromolecular_Interacting_Partner_30_References:
15586017; 15958725; 16150899; 16571785

End of HMDB00037

Beginning of HMDB00038
# Accession_No:
HMDB00038

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-12 16:42:13

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Dihydrobiopterin

# Description:
Dihydrobiopterin is an oxidation product of tetrahydrobiopterin. Tetrahydrobiopterin is a natural occurring cofactor of the aromatic amino acid hydroxylase and is involved in the synthesis of tyrosine and the neurotransmitters dopamine and serotonin. Tetrahydrobiopterin is also essential for nitric oxide synthase catalyzed oxidation of L-arginine to L-citrulline and nitric oxide.

# Synonyms:
(S-(R*,S*))-2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-4(1H)-Pteridinone; 2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-7,8-dihydro-4(1H)-Pteridinone; 2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-4(1H)-Pteridinone; 7,8-Dihydro-L-biopterin; 7,8-Dihydrobiopterin; Dihydrobiopterin; L-erythro-1-(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)-1,2-Propanediol; L-erythro-7,8-Dihydrobiopterin; L-erythro-Dihydrobiopterin; L-erythro-q-Dihydrobiopterin; Quinonoid dihydrobiopterin

# Chemical_IUPAC_Name:
2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-1H-pteridin-4-one

# Chemical_Formula:
C9H13N5O3

# Chemical_Structure:
tbl_chemical:::HMDB00038_ZOOM.png:::119283148486928636

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00038_THUMB.png:::119283148283844926

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Vitamins

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
imine; secondary alcohol; 1,2-diol; primary amine; primary aromatic amine; secondary amine; secondary aliphatic/aromatic amine (alkylarylamine); oxo(het)arene; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of Folate biosynthesis

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
239.10184

# Molecular_Weight_Avg:
239.23122

# Smiles_String_isomeric:
CC(O)C(O)C1=NC2=C(NC1)N=C(N)NC2=O

# Smiles_String_canonical:
CC(O)C(O)C1=NC2=C(NC1)N=C(N)NC2=O

# KEGG_Compound_ID:
C02953

# BioCyc_ID:
BIOPTERIN

# PubChem_CID:
252

# PubChem_SID:
2171; 5871; 6577875; 6591724

# OMIM_ID:
182125; 261630; 261640

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Not Available

# METLIN_ID:
5106

# Ref_ID:
8626754; 84153; 15182855; 12032193; 11301319; 932231; 3665086; 9753429; 11443547; 11738280

# ChEBI_ID:
15375

# CAS_Registry_Number:
6779-87-9

# InChI:
InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3,6,15-16H,2H2,1H3,(H4,10,11,13,14,17)

# Synthesis_Reference:
Not Available

# Melting_Point:
Not Available

# Melting_Point_predicted:
129.6 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
1.63 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-1.65 [Predicted by ALOGPS]; -2.2 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C02953.mol:::1132723802859476765

# SDF_File_[Text]:
tbl_chemical:::HMDB00038.sdf:::119283147848238602

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00038.pdb:::119283148116026132

# PDB_ID:
1DCP

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1DCP.txt:::1132720899546636990

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::7,8-Dihydrobiopterin.gif:::1132732101484228036

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00038_peaks.txt:::115630950391411275

# Predicted_C_NMR_Spectrum:
tbl_chemical:::7,8-Dihydrobiopterin_C.gif:::1132737664487506285

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00038_peaks.txt:::1156310695560477413

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00038L.png:::119015613756853229

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Blood; CSF

# Concentration_[Normal]:
Blood	0.006 +/- 0.0003	uM	Adult:>18_yrs_old	Both	Normal	12032193
Cerebrospinal_Fluid(CSF)	0.0004-0.014	uM	Adult:>18_yrs_old	Both	Normal	12032193


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Deficiency of Various Neurotransmitters in the Central Nervous System; Hyperphenylalaninemia

# Pathway_Names:
Folate biosynthesis

# Pathway_Images:
Not Available

# KEGG_Images:
map00790

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5673

# Metabolic_Enzyme_1_Name:
Sepiapterin reductase

# Metabolic_Enzyme_1_Synonyms:
SPR

# Metabolic_Enzyme_1_Gene_Name:
SPR

# Metabolic_Enzyme_1_Protein_Sequence:
>Sepiapterin reductase
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSG
LRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV
NNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML
FQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQK
LLSLLEKDEFKSGAHVDFYDK

# Metabolic_Enzyme_1_Number_of_Residues:
261

# Metabolic_Enzyme_1_Molecular_Weight:
28049

# Metabolic_Enzyme_1_Theoretical_pI:
8.19

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  sepiapterin reductase activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  cellular metabolism
Process:  aromatic compound metabolism
Process:  aromatic compound biosynthesis
Process:  pteridine and derivative biosynthesis
Process:  tetrahydrobiopterin biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin

# Metabolic_Enzyme_1_Pathway:
map00790  Folate biosynthesis

# Metabolic_Enzyme_1_Reaction:
7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.1.1.153

# Metabolic_Enzyme_1_GenBank_ID_Protein:
338021

# Metabolic_Enzyme_1_SwissProt_ID:
SPRE_HUMAN (P35270)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
SPR

# Metabolic_Enzyme_1_Geneatlas_id:
SPR

# Metabolic_Enzyme_1_hgnc_id:
HGNC:11257

# Metabolic_Enzyme_1_PDB_ID:
1Z6Z

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>786 bp
ATGGAGGGCGGGCTGGGGCGTGCTGTGTGCTTGCTGACCGGGGCCTCCCGCGGCTTCGGC
CGGACGCTGGCCCCGCTCCTGGCCTCGCTGCTGTCGCCCGGCTCCGTGCTTGTCCTTAGC
GCCCGCAACGACGAGGCACTGCGCCAGCTGGAGGCCGAGCTGGGCGCCGAGCGGTCTGGC
CTGCGCGTGGTGCGGGTGCCCGCCGACCTGGGCGCCGAGGCCGGCTTGCAGCAGCTGCTC
GGCGCCCTGCGCGAGCTCCCCCGGCCCAAGGGGCTGCAGCGACTGCTGCTTATCAACAAC
GCGGGCTCTCTTGGGGATGTGTCCAAAGGCTTCGTGGACCTGAGTGACTCCACTCAAGTG
AACAACTACTGGGCACTGAACTTGACCTCCATGCTCTGCCTGACTTCCAGCGTCCTGAAG
GCCTTCCCGGACAGTCCTGGCCTCAACAGAACCGTGGTTAACATCTCGTCCCTCTGTGCC
CTGCAACCTTTCAAAGGCTGGGCGCTGTACTGTGCAGGAAAGGCTGCTCGTGATATGCTG
TTCCAGGTCCTGGCGCTGGAGGAACCTAATGTGAGGGTGCTGAACTATGCCCCAGGTCCT
CTGGACACAGACATGCAGCAGTTGGCCCGGGAGACCTCCGTGGACCCAGACATGCGAAAA
GGGCTGCAGGAGCTGAAGGCAAAGGGGAAGCTGGTGGATTGCAAGGTGTCAGCCCAGAAA
CTGCTGAGCTTACTGGAAAAGGACGAGTTCAAGTCTGGAGCCCACGTGGACTTCTATGAC
AAATAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M76231

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_1_Locus:
2p14-p12

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
1883349; 8440319; 11825621

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6070

# Metabolic_Enzyme_2_Name:
Dihydrofolate reductase

# Metabolic_Enzyme_2_Synonyms:
Not Available

# Metabolic_Enzyme_2_Gene_Name:
DHFR

# Metabolic_Enzyme_2_Protein_Sequence:
>Dihydrofolate reductase
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND

# Metabolic_Enzyme_2_Number_of_Residues:
187

# Metabolic_Enzyme_2_Molecular_Weight:
21453

# Metabolic_Enzyme_2_Theoretical_pI:
7.60

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NADP binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
Function:  dihydrofolate reductase activity
 ||
>>>
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
Process:  glycine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8- dihydrofolate + NADPH

# Metabolic_Enzyme_2_Pathway:
map00670  One carbon pool by folate;
 map00790  Folate biosynthesis

# Metabolic_Enzyme_2_Reaction:
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00186:DHFR_1

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.5.1.3

# Metabolic_Enzyme_2_GenBank_ID_Protein:
182724

# Metabolic_Enzyme_2_SwissProt_ID:
DYR_HUMAN (P00374)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
DHFR

# Metabolic_Enzyme_2_Geneatlas_id:
DHFR

# Metabolic_Enzyme_2_hgnc_id:
HGNC:2861

# Metabolic_Enzyme_2_PDB_ID:
1MVT

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>564 bp
ATGGTTGGTTCGCTAAACTGCATCGTCGCTGTGTCCCAGAACATGGGCATCGGCAAGAAC
GGGGACCTGCCCTGGCCACCGCTCAGGAATGAATTCAGATATTTCCAGAGAATGACCACA
ACCTCTTCAGTAGAAGGTAAACAGAATCTGGTGATTATGGGTAAGAAGACCTGGTTCTCC
ATTCCTGAGAAGAATCGACCTTTAAAGGGTAGAATTAATTTAGTTCTCAGCAGAGAACTC
AAGGAACCTCCACAAGGAGCTCATTTTCTTTCCAGAAGTCTAGATGATGCCTTAAAACTT
ACTGAACAACCAGAATTAGCAAATAAAGTAGACATGGTCTGGATAGTTGGTGGCAGTTCT
GTTTATAAGGAAGCCATGAATCACCCAGGCCATCTTAAACTATTTGTGACAAGGATCATG
CAAGACTTTGAAAGTGACACGTTTTTTCCAGAAATTGATTTGGAGAAATATAAACTTCTG
CCAGAATACCCAGGTGTTCTCTCTGATGTCCAGGAGGAGAAAGGCATTAAGTACAAATTT
GAAGTATATGAGAAGAATGATTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
J00140

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_2_Locus:
5q11.2-q13.2

# Metabolic_Enzyme_2_SNPs:
rs1643630; rs2618372; rs1643650; rs6875184; rs10072026; rs11951910; rs836818; rs1643638; rs1677693; rs1643658; rs10078190; rs836823; rs836821; rs1643659; rs1677691; rs1643635; rs1677694; rs1677634; rs13161245; rs865646; rs1677633; rs844370; rs10052238; rs966762; rs865647; rs1650709; rs2431221; rs10054574; rs34965641; rs865645; rs1643649; rs525054; rs245104; rs11951283; rs1650700; rs1650711; rs245099; rs1650710; rs6453522; rs1677700; rs372069; rs34563643; rs1677696; rs1650714; rs1643664; rs864133; rs1623489; rs1650701; rs35709834; rs1677661; rs11742668; rs836819; rs861373; rs1677692; rs836822; rs860717; rs34781740; rs1677701; rs1650706; rs1650713; rs2560424; rs863216; rs2897261; rs1643657; rs1643661; rs1643634; rs1677666; rs12517451; rs1650723; rs12109877; rs1650720; rs14435; rs11112; rs1053136; rs11550953; rs1129240; rs1129243; rs2431220; rs7387; rs190293; rs34764978; rs35262215; rs1129242; rs34087552; rs10685456; rs1650717; rs13182730; rs1677706; rs10474631; rs34268388; rs35740086; rs6863377; rs10076523; rs2545005; rs1677704; rs1643662; rs1643647; rs1677697; rs7706270; rs10557831; rs2560423; rs3958540; rs863217; rs1677699; rs1643637; rs165957; rs3991269; rs4406117; rs34545755; rs3991268; rs245101; rs11305000; rs1643656; rs1677636; rs1677684; rs11490741; rs1650712; rs34132382; rs1677705; rs2897260; rs1677688; rs3958541; rs34289983; rs863215; rs1677686; rs1650707; rs34468903; rs1650715; rs245103; rs34184316; rs1677702; rs34288321; rs35372305; rs34122957; rs1643660; rs7705115; rs34674884; rs2434329; rs10942929; rs2927911; rs1650716; rs7706404; rs3797876; rs2405873; rs1222967; rs245105; rs1677689; rs34359040; rs11749051; rs1643648; rs2560422; rs1650718; rs1677631; rs10942928; rs34504711; rs11952744; rs3958542; rs35633165; rs1643636; rs836820; rs1650708; rs245100; rs7725721; rs34141487; rs11491447; rs1643663; rs34540063; rs8180493; rs1677687; rs1677695; rs33948142; rs1677685; rs13165178; rs10077031; rs34143020; rs390975; rs12109309; rs10168; rs10474632; rs1105524; rs1222809; rs1232027; rs1382539; rs1382540; rs1382541; rs1382542; rs1478834; rs1478835; rs1643639; rs1643641; rs1643646; rs1643655; rs1650675; rs1650676; rs1650681; rs1650692; rs1650694; rs1650695; rs1650696; rs1650697; rs1677626; rs1677667; rs1677670; rs1677682; rs1677703; rs245102; rs380691; rs3822706; rs384925; rs408626; rs442767; rs453544; rs6878815; rs6897872; rs701383; rs861365

# Metabolic_Enzyme_2_General_References:
6323448; 6687716; 6235374; 3383852; 2248959; 9374868; 1731871

# Metabolic_Enzyme_2_References:
4004257; 759569; 8490294; 8569700

# Metabolic_Enzyme_3_ID:
5816

# Metabolic_Enzyme_3_Name:
Dihydropteridine reductase

# Metabolic_Enzyme_3_Synonyms:
HDHPR; Quinoid dihydropteridine reductase

# Metabolic_Enzyme_3_Gene_Name:
QDPR

# Metabolic_Enzyme_3_Protein_Sequence:
>Dihydropteridine reductase
MAAAAAAGEARRVLVYGGRGALGSRCVQAFRARNWWVASVDVVENEEASASIIVKMTDSF
TEQADQVTAEVGKLLGEEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSH
LATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAV
LPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGKNRPSSGSLIQVVTTEGRTELT
PAYF

# Metabolic_Enzyme_3_Number_of_Residues:
244

# Metabolic_Enzyme_3_Molecular_Weight:
25790

# Metabolic_Enzyme_3_Theoretical_pI:
7.45

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases

# Metabolic_Enzyme_3_Pathway:
map00790  Folate biosynthesis

# Metabolic_Enzyme_3_Reaction:
a 5,6,7,8-tetrahydropteridine + NAD(P)+ = a 6,7-dihydropteridine + NAD(P)H + H+

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.5.1.34

# Metabolic_Enzyme_3_GenBank_ID_Protein:
30819

# Metabolic_Enzyme_3_SwissProt_ID:
DHPR_HUMAN (P09417)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
QDPR

# Metabolic_Enzyme_3_Geneatlas_id:
QDPR

# Metabolic_Enzyme_3_hgnc_id:
HGNC:9752

# Metabolic_Enzyme_3_PDB_ID:
1HDR

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>735 bp
ATGGCGGCGGCGGCGGCTGCAGGCGAGGCGCGCCGGGTGCTGGTGTACGGCGGCAGGGGC
GCTCTGGGTTCTCGATGCGTGCAGGCTTTTCGGGCCCGCAACTGGTGGGTTGCCAGCGTT
GATGTGGTGGAGAATGAAGAGGCCAGCGCTACGATCATTGTTAAAATGACAGACTCGTTC
ACTGAGCAGGCTGACCAGGTGACTGCTGAGGTTGGAAAGCTCTTGGGTGAAGAGAAGGTG
GATGCAATTCTTTGCGTTGCTGGAGGATGGGCCGGGGGCAATGCCAAATCCAAGTCTCTC
TTTAAGAACTGTGACCTGATGTGGAAGCAGAGCATATGGACATCGACCATCTCCAGCCAT
CTGGCTACCAAGCATCTCAAGGAAGGAGGCCTCCTGACCTTGGCTGGCGCAAAGGCTGCC
CTGGATGGGACTCCTGGTATGATCGGGTACGGCATGGCCAAGGGTGCTGTTCACCAGCTC
TGCCAGAGCCTGGCTGGGAAGAACAGCGGCATGCCGCCCGGGGCAGCCGCCATCGCTGTG
CTCCCGGTTACCCTGGATACCCCGATGAACAGGAAATCAATGCCTGAGGCTGACTTCAGC
TCCTGGACACCCTTAGAATTCCTAGTTGAAACTTTCCATGACTGGATCACAGGGAAAAAC
CGACCGAGCTCAGGAAGCCTAATCCAGGTGGTAACCACAGAAGGAAGGACGGAACTCACC
CCAGCATATTTTTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X04882

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_3_Locus:
4p15.31

# Metabolic_Enzyme_3_SNPs:
rs3733570; rs12645938; rs3733569; rs2597775; rs1031327; rs1031326; rs1049581; rs1049600; rs699459; rs1049601; rs10604; rs699460; rs1049582; rs2597778; rs10008024; rs10006709; rs1411985; rs2315248; rs12644621; rs10939729; rs2518609; rs3822231; rs3733575; rs12512471; rs10004095; rs4698601; rs6819744; rs6827193; rs7660043; rs2518613; rs2518610; rs2597770; rs11722315; rs744729; rs2518616; rs731437; rs17458406; rs2253130; rs3796809; rs10013112; rs3094278; rs2252995; rs7696913; rs12647753; rs2518618; rs2597768; rs744731; rs2518615; rs7662925; rs9998021; rs10516314; rs10000532; rs10011038; rs2244804; rs12644449; rs12498807; rs9995626; rs3775922; rs10084995; rs11946133; rs3733572; rs2597777; rs12511229; rs13121927; rs3733573; rs28418409; rs10939724; rs10939725; rs7670743; rs3775921; rs3733574; rs3822234; rs2597767; rs744730; rs7676618; rs10030250; rs10020171; rs2518624; rs2518625; rs2597766; rs6449303; rs6811303; rs2244788; rs2597765; rs2305316; rs2597764; rs2597781; rs2518623; rs1031325; rs2315246; rs2315247; rs12512495; rs11556809; rs2518608; rs11556811; rs41268391; rs1803486; rs35601449; rs9995723; rs28407193; rs2305315; rs2518614; rs6841929; rs34374888; rs35810383; rs2597769; rs2518611; rs2597771; rs10027962; rs10031275; rs3733571; rs28678909; rs2597774; rs28587968; rs28465580; rs10008333; rs41268393; rs28547068; rs7436922; rs28394602; rs36202813; rs28548890; rs4083729; rs10028346; rs34235865; rs28391487; rs10050325; rs5856425; rs35863325; rs28375535; rs34319569; rs34528211; rs11736337; rs3822233; rs28435289; rs2597773; rs2518612; rs35068359; rs12498326; rs34914923; rs34012502; rs13137081; rs35469730; rs34100425; rs35826618; rs28449900; rs10632253; rs12647416; rs28580482; rs34858847; rs35314811; rs2597776; rs10598892; rs3217604; rs2597779; rs28621908; rs5856426; rs11351628; rs10022501; rs28425622; rs7685575; rs2518622; rs2597772; rs35054011; rs34311884; rs7660847; rs36094070; rs35198436; rs3066734; rs2597780; rs11935131; rs6823650; rs7672603; rs7694662; rs2518606; rs11556808; rs2597782; rs2518607; rs10026004; rs11733530; rs12499694; rs13128422; rs13128427; rs13128864; rs13131273; rs13138275; rs1473352; rs1551091; rs1551092; rs16895134; rs16895143; rs1868733; rs1868734; rs1868735; rs2122571; rs2247952; rs2518603; rs2518604; rs2518605; rs2518626; rs2597752; rs2597753; rs2597754; rs2597755; rs2597756; rs2597757; rs2597758; rs2597783; rs2597784; rs2597786; rs2697688; rs2697689; rs4698189; rs4698599; rs4698603; rs6817052; rs6835304; rs7661303

# Metabolic_Enzyme_3_General_References:
3031582; 3033643; 9744478; 8262916; 7627180; 8326489; 2116088; 10408783; 11153907

# Metabolic_Enzyme_3_References:
8490294

End of HMDB00038

Beginning of HMDB00039
# Accession_No:
HMDB00039

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-25 16:42:35

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Butyric acid

# Description:
Butyric acid, the four-carbon fatty acid, is formed in the human colon by bacterial fermentation of carbohydrates (including dietary fiber), and putatively suppresses colorectal cancer (CRC).  Butyrate has diverse and apparently paradoxical effects on cellular proliferation, apoptosis and differentiation that may be either pro-neoplastic or anti-neoplastic, depending upon factors such as the level of exposure, availability of other metabolic substrate and the intracellular milieu.  In humans, the relationship between luminal butyrate exposure and CRC has been examined only indirectly in case-control studies, by measuring fecal butyrate concentrations, although this may not accurately reflect effective butyrate exposure during carcinogenesis.  Perhaps not surprisingly, results of these investigations have been mutually contradictory.  The direct effect of butyrate on tumorigenesis has been assessed in a no. of in vivo animal models, which have also yielded conflicting results.  In part, this may be explained by methodology: differences in the amount and route of butyrate administration, which are likely to significantly influence delivery of butyrate to the distal colon.  (PMID 16460475) Butyric acid is a carboxylic acid found in rancid butter, parmesan cheese, and vomit, and has an unpleasant odor and acrid taste, with a sweetish aftertaste (similar to ether). Butyric acid is a fatty acid occurring in the form of esters in animal fats and plant oils. Interestingly, low-molecular-weight esters of butyric acid, such as methyl butyrate, have mostly pleasant aromas or tastes. As a consequence, they find use as food and perfume additives. Butyrate is produced as end-product of a fermentation process solely performed by obligate anaerobic bacteria.

# Synonyms:
1-Butyrate; 1-Butyric acid; 1-Propanecarboxylate; 1-Propanecarboxylic acid; 1-butanoate; 1-butanoic acid; Butanate; Butanic acid; Butanoate; Butanoic acid; Buttersaeure; Butyrate; Ethylacetate; Ethylacetic acid; Honey robber; Kyselina maselna; Propanecarboxylate; Propanecarboxylic acid; Propylformate; Propylformic acid; butyric acid; n-Butanoate; n-Butanoic acid; n-Butyrate; n-Butyric acid

# Chemical_IUPAC_Name:
Butanoic acid

# Chemical_Formula:
C4H8O2

# Chemical_Structure:
tbl_chemical:::HMDB00039_ZOOM.png:::119283149338870780

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00039_THUMB.png:::11928314916101480

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
carboxylic acid

# Taxonomy_Biofunction:
Energy source; DNA component

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
88.05243

# Molecular_Weight_Avg:
88.10513

# Smiles_String_isomeric:
CCCC(O)=O

# Smiles_String_canonical:
CCCC(O)=O

# KEGG_Compound_ID:
C00246

# BioCyc_ID:
Not Available

# PubChem_CID:
264

# PubChem_SID:
3545; 7886373; 11120324; 587668; 11447352; 7849658; 8145230; 639195; 584341; 829106; 11528267; 11405819; 10318186; 2182; 539318; 151005; 11120812; 10503556; 8150539; 841341; 10348531; 4802290; 7986037; 10318189; 833290; 563607; 7853006; 825651; 74110; 11121300; 8137924; 3132316

# OMIM_ID:
Not Available

# Metagene_ID:
GABA TRANSAMINASE DEFICIENCY: 32; HYPER BETA-ALANINEMIA: 204; 4-HYDROXYBUTYRIC ACIDURIA: 7; ARTEFACTS-PHARMACEUTICAL PRODUCTS, INTERFERENCE IN AMINOACID AND ORGANIC ACID ANALYSIS [DD]: 347; 3-HYDROXYISOBUTYRIC ACIDURIA: 307; 2-HYDROXYGLUTARIC ACIDURIA (D): 281; MAPLE SYRUP URINE DISEASE. BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE DEFICIENCY (MSUD): 1; PYRIDOXINE DEPENDENCY WITH SEIZURES: 360; 2-METHYL-3-HYDROXYBUTYRYL-CoA DEHYDROGENASE DEFICIENCY: 457; PERSISTANT HYPERINSULINEMIC HYPOGLYCEMIA OF INFANCY, PHHI: 255; FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY: 128; MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD): 39; GLUTARIC ACIDURIA II: 9; KETOSIS, UNSPECIFIC [DD]: 279; METHYLMALONIC ACIDURIA (MMA): 15; GLUTARIC ACIDURIA I: 8; ASPHYXIA [DD]: 408; LONG-CHAIN-3-HYDROXYACYL-CoA DEHYDROGENASE DEFICIENCY (LCHAD): 308; SHORT-CHAIN 3-HYDROXYACYL-CoA DEHYDROGENASE DEFICIENCY (SCHAD): 393; BIOTINIDASE DEFICIENCY: 73; ISOVALERIC ACIDEMIA: 10; BETA-KETOTHIOLASE DEFICIENCY: 5; METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY: 485

# BiGG_ID:
34376

# Wikipedia_ID:
Butyric acid

# METLIN_ID:
107

# Ref_ID:
12618885; 6826253; 12097436; 12663299; 12067385; 6288683; 15193738; 12004211; 15385498; 14745451; 6268944; 15703366; 15800932; 11953371; 9244653; 9361838; 6257378; 9071566

# ChEBI_ID:
30772

# CAS_Registry_Number:
107-92-6

# InChI:
InChI=1/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)

# Synthesis_Reference:
 Journal of the Chemical Society  (1934),     26-9.

# Melting_Point:
-5.7 oC

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
60.0 mg/mL [HEMPHILL,L & SWANSON,WS (1964)]

# H2O_Solubility_Predicted:
239.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Liquid

# LogP:
0.79 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
0.78 [Predicted by ALOGPS]; 0.7 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Butyric acid Na salt.htm:::1132562192618105579

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Butyric_acid.mol:::1132723802953871928

# SDF_File_[Text]:
tbl_chemical:::HMDB00039.sdf:::119283148874851826

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00039.pdb:::119283149028654015

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041004_P00_05_HW_1DP_PRESAT_expanded_2.gif:::11416824637978376

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041004_P00_05_HW_1DP_presat.zip:::1175124407386523404

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041004_P00_05_HW_1DP_Assigned.png:::114659877040280025

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::107-92-6-presat_JM.GIF:::1132883804765529763

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041004_P00_05_HW_1DP_PRESAT_1.zip:::11446078492841069

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
tbl_cnmr:::041004_P00_05_HW_1DC_17.jpg:::11443659266855339

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041004_P00_05_HW_1DC_17.zip:::114436592672920288

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041004_P00_05_HW_1DC_17_Assigned.jpg:::114488409548798836

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041004_P00_05_HW_2DHSQC_59.jpg:::11448841775699721

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041004_P00_05_HW_2DHSQC_59.zip:::114488417760476664

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041004_P00_05_HW_2DHSQC_59_Assigned.jpg:::114488417779319269

# Predicted_H_NMR_Spectrum:
tbl_chemical:::butyric acid.gif:::1132732101515281785

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00039_peaks.txt:::1156309504938619381

# Predicted_C_NMR_Spectrum:
tbl_chemical:::butyric acid_C.gif:::1132737664537530469

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00039_peaks.txt:::1156310696578392874

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00039L.png:::117555262540864016; Medium Energy:tbl_ms:::HMDB00039M.png:::117555267886184459; High Energy:tbl_ms:::HMDB00039H.png:::117555271486213415

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria

# Tissue_Location:
Fibroblasts; Intestine; Kidney; Large Intestine; Muscle; Neurons; Prostate

# deuterated:
No

# Biofluid_Location:
Bile; Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Urine	0.086 +/- 0.0085	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9071566
Blood	1.0 (0.3- 1.5)	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	1.4 (0-2.8)	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Saliva	1470 (0.00-2940)	umol/L	Adult:>18_yrs_old	Both	Normal	12097436


# Concentration_[Abnormal]:
Urine	0.18 +/- 0.044	umol/mmol_creatinine	Adult:>18_yrs_old	Both	AIDS	9071566


# Associated_Disorders:
AIDS; Crohn's Disease; Hypoglycemia; Ulcerative Colitis

# Pathway_Names:
Butanoate metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00650

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5823

# Metabolic_Enzyme_1_Name:
Middle-chain acyl-CoA synthetase1

# Metabolic_Enzyme_1_Synonyms:
Medium-chain acyl-CoA synthetase

# Metabolic_Enzyme_1_Gene_Name:
BUCS1

# Metabolic_Enzyme_1_Protein_Sequence:
>Middlechain acylCoA synthetase1
MQWLMRFRTLWGIHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLDYWA
QKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPR
VPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIASQCP
SLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHSH
GLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQFDTK
VIIQTLLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWKRRTG
LLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVIDDKGSILPPNTEGNIGIRI
KPVRPVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIG
PAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSV
TAPYKYPRNVEFVSELPKTITGKIERKELRKKETGQM

# Metabolic_Enzyme_1_Number_of_Residues:
577

# Metabolic_Enzyme_1_Molecular_Weight:
65260

# Metabolic_Enzyme_1_Theoretical_pI:
8.28

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Not Available

# Metabolic_Enzyme_1_Pathway:
Not Available

# Metabolic_Enzyme_1_Reaction:
Not Available

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 6.2.1.2

# Metabolic_Enzyme_1_GenBank_ID_Protein:
15706421

# Metabolic_Enzyme_1_SwissProt_ID:
Q96A20_HUMAN (Q96A20)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
BUCS1

# Metabolic_Enzyme_1_Geneatlas_id:
BUCS1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:18049

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1734 bp
ATGCAGTGGCTAATGAGGTTCCGGACCCTCTGGGGCATCCACAAATCCTTCCACAACATC
CACCCTGCCCCTTCACAGCTGCGCTGCCGGTCTTTATCAGAATTTGGAGCCCCAAGATGG
AATGACTATGAAGTACCGGAGGAATTTAACTTTGCAAGTTATGTACTGGACTACTGGGCT
CAAAAGGAGAAGGAGGGCAAGAGAGGTCCAAATCCAGCTTTTTGGTGGGTGAATGGCCAA
GGGGATGAAGTAAAGTGGAGCTTCAGAGAGATGGGAGACCTAACCCGCCGTGTAGCCAAC
GTCTTCACACAGACCTGTGGCCTACAACAGGGAGACCATCTGGCCTTGATGCTGCCTCGA
GTTCCTGAGTGGTGGCTGGTGGCTGTGGGCTGCATGCGAACAGGGATCATCTTCATTCCT
GCGACCATCCTGTTGAAGGCCAAAGACATTCTCTATCGACTACAGTTGTCTAAAGCCAAG
GGCATTGTGACCATAGATGCCCTTGCCTCAGAGGTGGACTCCATAGCTTCTCAGTGCCCC
TCTCTGAAAACCAAGCTCCTGGTGTCTGATCACAGCCGTGAAGGGTGGCTGGACTTCCGA
TCGCTGGTTAAATCAGCATCCCCAGAACACACCTGTGTTAAGTCAAAGACCTTGGACCCA
ATGGTCATCTTCTTCACCAGTGGGACCACAGGCTTCCCCAAGATGGCAAAACACTCCCAT
GGGTTGGCCTTACAACCCTCCTTCCCAGGAAGTAGGAAATTACGGAGCCTGAAGACATCT
GATGTCTCCTGGTGCCTGTCGGACTCAGGATGGATTGTGGCTACCATTTGGACCCTGGTA
GAACCATGGACAGCGGGTTGTACAGTCTTTATCCACCATCTGCCACAGTTTGACACCAAG
GTCATCATACAGACATTGTTGAAATACCCCATTAACCACTTTTGGGGGGTATCATCTATA
TATCGAATGATTCTGCAGCAGGATTTCACCAGCATCAGGTTCCCTGCCCTGGAGCACTGC
TATACTGGCGGGGAGGTCGTGTTGCCCAAGGATCAGGAGGAGTGGAAAAGACGGACGGGC
CTTCTGCTCTACGAGAACTATGGGCAGTCGGAAACGGGACTAATTTGTGCCACCTACTGG
GGAATGAAGATCAAGCCGGGTTTCATGGGGAAGGCCACTCCACCCTATGACGTCCAGGTC
ATTGATGACAAGGGCAGCATCCTGCCACCTAACACAGAAGGAAACATTGGCATCAGAATC
AAACCTGTCAGGCCTGTGAGCCTCTTCATGTGCTATGAGGGTGACCCAGAGAAGACAGCT
AAAGTGGAATGTGGGGACTTCTACAACACTGGGGACAGAGGAAAGATGGATGAAGAGGGC
TACATTTGTTTCCTGGGGAGGAGTGATGACATCATTAATGCCTCTGGGTATCGCATCGGG
CCTGCAGAGGTTGAAAGCGCTTTGGTGGAGCACCCAGCGGTGGCGGAGTCAGCCGTGGTG
GGCAGCCCAGACCCGATTCGAGGGGAGGTGGTGAAGGCCTTTATTGTCCTGACCCCACAG
TTCCTGTCCCATGACAAGGATCAGCTGACCAAGGAACTGCAGCAGCATGTCAAGTCAGTG
ACAGCCCCATACAAGTACCCAAGGAACGTGGAGTTTGTCTCAGAGCTGCCAAAAACCATC
ACTGGCAAGATTGAACGGAAGGAACTTCGGAAAAAGGAGACTGGTCAGATGTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AB062503

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_1_Locus:
16p12.2

# Metabolic_Enzyme_1_SNPs:
rs8056709; rs16970453; rs151328; rs3743690; rs2301672; rs1692729; rs3087812; rs6497510; rs1390818; rs7195380; rs3883991; rs1112308; rs6497512; rs7191240; rs3907531; rs3907532; rs1390819; rs7195927; rs2521576; rs9927979; rs10852245; rs4783410; rs9927872; rs433598; rs1551567; rs163236; rs151327; rs7498905; rs163235; rs163274; rs397132; rs163275; rs399499; rs163238; rs168102; rs163265; rs163269; rs163276; rs231921; rs163259; rs163273; rs396508; rs163277; rs1845919; rs395501; rs17688192; rs992381; rs231930; rs163278; rs180286; rs234280; rs3913150; rs1673057; rs16970493; rs163271; rs163234; rs4092390; rs163242; rs11643793; rs151309; rs11864505; rs16970500; rs9930741; rs234279; rs9930784; rs151310; rs231928; rs12928136; rs9930187; rs163237; rs7202947; rs163268; rs7187142; rs7198885; rs234288; rs163257; rs16970542; rs3743689; rs163239; rs9926662; rs1845918; rs13339208; rs163262; rs11866223; rs1673062; rs13334726; rs163256; rs10400933; rs9929412; rs151222; rs9937963; rs170897; rs151329; rs7203759; rs234276; rs11641336; rs163255; rs16970539; rs16970475; rs11643819; rs1673067; rs231927; rs2645264; rs163260; rs163272; rs231929; rs234993; rs16970506; rs9937871; rs163240; rs1473539; rs180149; rs1673071; rs163245; rs1673069; rs9922083; rs1673060; rs2524397; rs231923; rs163263; rs163241; rs12929282; rs234286; rs7189209; rs9933531; rs8046100; rs163267; rs9937753; rs163244; rs1673061; rs163246; rs234278; rs11860368; rs2935289; rs876106; rs1673070; rs2905825; rs1390811; rs1551568; rs9932231; rs9935309; rs937380; rs13337936; rs978161; rs7189675; rs1948567; rs870940; rs163251; rs870941; rs978160; rs13333421; rs16970511; rs2645266; rs4105168; rs4028210; rs34297096; rs35070485; rs5816128; rs34283792; rs7205700; rs1353560; rs11866514; rs11482245; rs3905816; rs2791579; rs9708612; rs4028209; rs6497509; rs34163951; rs36091171; rs35100724; rs5816129; rs2791578; rs2645267; rs2524395; rs2636952; rs34133125; rs338306; rs1692728; rs2645265; rs10696412; rs163270; rs163266; rs12928278; rs231926; rs34844087; rs193138; rs407385; rs34880359; rs12918948; rs553823; rs34392148; rs34719963; rs12928554; rs180031; rs12923779; rs36118125; rs551997; rs231931; rs2935290; rs34261689; rs28617427; rs35367768; rs13330264; rs36139670; rs34141030; rs163261; rs28407561; rs407115; rs13334424; rs34051844; rs34001827; rs234273; rs28504227; rs34600525; rs12928747; rs193137; rs7501250; rs12050994; rs3073712; rs35700474; rs420735; rs28502691; rs35210350; rs193136; rs231920; rs34430083; rs2524396; rs12443593; rs9927399; rs35868298; rs34164754; rs34630589; rs186824; rs10573087; rs9939024; rs151330; rs12444145; rs34734974; rs231932; rs28641656; rs35787577; rs1673068; rs34036026; rs234272; rs11866405; rs35427586; rs35998307; rs231924; rs163258; rs4102379; rs4783458; rs5816130; rs1692730; rs234275; rs28426994; rs231919; rs35083253; rs34512335; rs34183294; rs28412173; rs34043568; rs35383605; rs2645263; rs35604326; rs5816131; rs1258920; rs163264; rs34586953; rs12921149; rs34327518; rs34192117; rs163243; rs180033; rs34123913; rs12922706; rs407374; rs12923773; rs34679769; rs28835921; rs28704796; rs12929314; rs28682534; rs33995958; rs4102380; rs9923104; rs28419751; rs552941; rs4783459; rs10696411; rs28635930; rs12922692; rs34041438; rs34894022; rs36182498; rs12924069; rs13333306; rs5816133; rs170924; rs35122439; rs2880113; rs35868801; rs151307; rs231922; rs407376; rs12923216; rs36099382; rs12922571; rs231925; rs11649650; rs7500012; rs2355929; rs28648969; rs28460160; rs35087522; rs168103; rs231933; rs151308; rs1460; rs10613980; rs10564254; rs10613979; rs1464; rs35507753; rs28739281; rs10431893; rs11643502; rs11859792; rs1390812; rs1390816; rs1496759; rs1496763; rs163253; rs16970546; rs3073716; rs34661230; rs7202085; rs7498582; rs8047205; rs8048603; rs9925895; rs9937289; rs9938235

# Metabolic_Enzyme_1_General_References:
11470804

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
7792

# Metabolic_Enzyme_2_Name:
Mitogen-activated protein kinase 14

# Metabolic_Enzyme_2_Synonyms:
Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAX-interacting protein 2; MAP kinase MXI2; SAPK2A

# Metabolic_Enzyme_2_Gene_Name:
MAPK14

# Metabolic_Enzyme_2_Protein_Sequence:
>Mitogenactivated protein kinase 14
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES


# Metabolic_Enzyme_2_Number_of_Residues:
360

# Metabolic_Enzyme_2_Molecular_Weight:
41294

# Metabolic_Enzyme_2_Theoretical_pI:
5.58

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis

# Metabolic_Enzyme_2_Pathway:
Not Available

# Metabolic_Enzyme_2_Reaction:
Not Available

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00069:Pkinase

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.7.11.24

# Metabolic_Enzyme_2_GenBank_ID_Protein:
603917

# Metabolic_Enzyme_2_SwissProt_ID:
MK14_HUMAN (Q16539)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
MAPK14

# Metabolic_Enzyme_2_Geneatlas_id:
MAPK14

# Metabolic_Enzyme_2_hgnc_id:
HGNC:6876

# Metabolic_Enzyme_2_PDB_ID:
1W84

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm. Nucleus (By similarity)

# Metabolic_Enzyme_2_Gene_Sequence:
>1083 bp
ATGTCTCAGGAGAGGCCCACGTTCTACCGGCAGGAGCTGAACAAGACAATCTGGGAGGTG
CCCGAGCGTTACCAGAACCTGTCTCCAGTGGGCTCTGGCGCCTATGGCTCTGTGTGTGCT
GCTTTTGACACAAAAACGGGGTTACGTGTGGCAGTGAAGAAGCTCTCCAGACCATTTCAG
TCCATCATTCATGCGAAAAGAACCTACAGAGAACTGCGGTTACTTAAACATATGAAACAT
GAAAATGTGATTGGTCTGTTGGACGTTTTTACACCTGCAAGGTCTCTGGAGGAATTCAAT
GATGTGTATCTGGTGACCCATCTCATGGGGGCAGATCTGAACAACATTGTGAAATGTCAG
AAGCTTACAGATGACCATGTTCAGTTCCTTATCTACCAAATTCTCCGAGGTCTAAAGTAT
ATACATTCAGCTGACATAATTCACAGGGACCTAAAACCTAGTAATCTAGCTGTGAATGAA
GACTGTGAGCTGAAGATTCTGGATTTTGGACTGGCTCGGCACACAGATGATGAAATGACA
GGCTACGTGGCCACTAGGTGGTACAGGGCTCCTGAGATCATGCTGAACTGGATGCATTAC
AACCAGACAGTTGATATTTGGTCAGTGGGATGCATAATGGCCGAGCTGTTGACTGGAAGA
ACATTGTTTCCTGGTACAGACCATATTAACCAGCTTCAGCAGATTATGCGTCTGACAGGA
ACACCCCCCGCTTATCTCATTAACAGGATGCCAAGCCATGAGGCAAGAAACTATATTCAG
TCTTTGACTCAGATGCCGAAGATGAACTTTGCGAATGTATTTATTGGTGCCAATCCCCTG
GCTGTCGACTTGCTGGAGAAGATGCTTGTATTGGACTCAGATAAGAGAATTACAGCGGCC
CAAGCCCTTGCACATGCCTACTTTGCTCAGTACCACGATCCTGATGATGAACCAGTGGCC
GATCCTTATGATCAGTCCTTTGAAAGCAGGGACCTCCTTATAGATGAGTGGAAAAGCCTG
ACCTATGATGAAGTCATCAGCTTTGTGCCACCACCCCTTGACCAAGAAGAGATGGAGTCC
TGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
L35263

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_2_Locus:
6p21.3-p21.2

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
7997261; 7696354; 7479834; 10727080; 11866441; 14574404; 12665801; 7923354; 7493921; 10943842; 10838079; 8910361; 9095200; 9753691

# Metabolic_Enzyme_2_References:
12618885; 14745139; 16356138

# Macromolecular_Interacting_Partner_1_ID:
7549

# Macromolecular_Interacting_Partner_1_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
INS

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_1_Signals:
1-24

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
INS

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11p15.5

# Macromolecular_Interacting_Partner_1_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_1_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_1_References:
16320810; 16614387

# Macromolecular_Interacting_Partner_2_ID:
7551

# Macromolecular_Interacting_Partner_2_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_2_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_2_Locus:
6p21.3

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_2_References:
14512034; 14720504; 14978972; 15063780

# Macromolecular_Interacting_Partner_3_ID:
7552

# Macromolecular_Interacting_Partner_3_Name:
Interferon gamma precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
IFN-gamma; Immune interferon

# Macromolecular_Interacting_Partner_3_Gene_Name:
IFNG

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Interferon gamma precursor
MKYTSYILAFQLCIVLGSLGCYCQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWK
EESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTN
YSVTDLNVQRKAIHELIQVMAELSPAAKTGKRKRSQMLFRGRRASQ

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
166

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
19349

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
10.01

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interferon-gamma receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00714:IFN-gamma

# Macromolecular_Interacting_Partner_3_Signals:
1-23

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
32692

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
IFNG_HUMAN (P01579)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
IFNG

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
IFNG

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:5438

# Macromolecular_Interacting_Partner_3_PDB_ID:
1HIG

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>501 bp
ATGAAATATACAAGTTATATCTTGGCTTTTCAGCTCTGCATCGTTTTGGGTTCTCTTGGC
TGTTACTGCCAGGACCCATATGTAAAAGAAGCAGAAAACCTTAAGAAATATTTTAATGCA
GGTCATTCAGATGTAGCGGATAATGGAACTCTTTTCTTAGGCATTTTGAAGAATTGGAAA
GAGGAGAGTGACAGAAAAATAATGCAGAGCCAAATTGTCTCCTTTTACTTCAAACTTTTT
AAAAACTTTAAAGATGACCAGAGCATCCAAAAGAGTGTGGAGACCATCAAGGAAGACATG
AATGTCAAGTTTTTCAATAGCAACAAAAAGAAACGAGATGACTTCGAAAAGCTGACTAAT
TATTCGGTAACTGACTTGAATGTCCAACGCAAAGCAATACATGAACTCATCCAAGTGATG
GCTGAACTGTCGCCAGCAGCTAAAACAGGGAAGCGAAAAAGGAGTCAGATGCTGTTTCAA
GGTCGAAGAGCATCCCAGTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
X13274

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_3_Locus:
12q14

# Macromolecular_Interacting_Partner_3_SNPs:
rs2069723; rs2069734; rs2069722; rs2234687; rs1042274; rs2069721; rs2069718; rs1861493; rs2069719; rs2069714; rs2069716; rs2069720; rs1861494; rs2069713; rs2069717; rs9282708; rs2234685; rs3087272; rs2069715; rs2069733; rs2430561; rs2193049; rs2069728; rs2069705; rs2069724; rs2069731; rs2193050; rs2069725; rs2069709; rs3181034; rs2069727; rs2069736; rs2069707; rs7956940; rs7956720; rs2069706; rs2069732; rs9282709; rs2069729; rs2069726; rs2069730; rs2069710; rs7957366; rs35040375; rs35314021; rs34079299; rs2069712; rs10611634; rs2234686; rs34399538; rs2069711; rs28910281; rs10599707; rs35008976; rs35994963; rs2069737; rs35751061; rs7956688; rs2069735; rs35815094; rs3814242; rs4394909; rs2069708; rs10878762; rs10878763; rs11177072; rs11177073; rs11177074; rs11831576; rs12306852; rs12366912; rs12369470; rs2098395; rs2111059; rs2870953; rs3181032; rs3181033; rs3181035; rs6421227; rs6581791; rs6581794; rs6581795; rs7138107; rs7139169; rs7298719; rs7302488; rs7350604; rs7968411; rs7969745

# Macromolecular_Interacting_Partner_3_General_References:
6180322; 6173769; 2860101; 6329718; 6176945; 6427223; 3109913; 2504704; 1902591; 7617032; 10860730; 1525157

# Macromolecular_Interacting_Partner_3_References:
12875900; 14517348; 15025822; 15123634

# Macromolecular_Interacting_Partner_4_ID:
7569

# Macromolecular_Interacting_Partner_4_Name:
Interleukin-6 precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF

# Macromolecular_Interacting_Partner_4_Gene_Name:
IL6

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Interleukin6 precursor
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYI
LDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLL
EFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQ
AQNQWLQDMTTHLILRSFKEFLQSSLRALRQM

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
212

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
23718

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.52

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interleukin-6 receptor binding
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
IL-6 is a cytokine with a wide variety of biological functions:it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00489:IL6

# Macromolecular_Interacting_Partner_4_Signals:
1-29

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
32674

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
IL6_HUMAN (P05231)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
IL6

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
IL6

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:6018

# Macromolecular_Interacting_Partner_4_PDB_ID:
2IL6

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>639 bp
ATGAACTCCTTCTCCACAAGCGCCTTCGGTCCAGTTGCCTTCTCCCTGGGGCTGCTCCTG
GTGTTGCCTGCTGCCTTCCCTGCCCCAGTACCCCCAGGAGAAGATTCCAAAGATGTAGCC
GCCCCACACAGACAGCCACTCACCTCTTCAGAACGAATTGACAAACAAATTCGGTACATC
CTCGACGGCATCTCAGCCCTGAGAAAGGAGACATGTAACAAGAGTAACATGTGTGAAAGC
AGCAAAGAGGCACTGGCAGAAAACAACCTGAACCTTCCAAAGATGGCTGAAAAAGATGGA
TGCTTCCAATCTGGATTCAATGAGGAGACTTGCCTGGTGAAAATCATCACTGGTCTTTTG
GAGTTTGAGGTATACCTAGAGTACCTCCAGAACAGATTTGAGAGTAGTGAGGAACAAGCC
AGAGCTGTCCAGATGAGTACAAAAGTCCTGATCCAGTTCCTGCAGAAAAAGGCAAAGAAT
CTAGATGCAATAACCACCCCTGACCCAACCACAAATGCCAGCCTGCTGACGAAGCTGCAG
GCACAGAACCAGTGGCTGCAGGACATGACAACTCATCTCATTCTGCGCAGCTTTAAGGAG
TTCCTGCAGTCCAGCCTGAGGGCTCTTCGGCAAATGTAG

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
X04430

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_4_Locus:
7p21

# Macromolecular_Interacting_Partner_4_SNPs:
rs2069860; rs13306435; rs2069830; rs2069849; rs2069850; rs2069851; rs13306436; rs2069857; rs3087226; rs1474347; rs2069833; rs2069832; rs1554606; rs2069842; rs1548216; rs2069840; rs2066992; rs1474348; rs2069835; rs2069831; rs2069845; rs2069838; rs2069834; rs2069837; rs1524107; rs2069841; rs3087232; rs13306433; rs34277345; rs2069847; rs3087227; rs2069848; rs35361244; rs34249410; rs3087228; rs3087233; rs3087230; rs2069843; rs3087229; rs2069844; rs3087231; rs2069858; rs1800795; rs2069824; rs1800797; rs7802308; rs1800796; rs7802307; rs2069829; rs3087223; rs2069827; rs2069825; rs3087225; rs2069861; rs36215814; rs2234683; rs2069828; rs11544633; rs41477054; rs13306438; rs3915892; rs3915893; rs2069839; rs13306434; rs3087234; rs2069846; rs2069836; rs3087235; rs2069859; rs13447445; rs36215459; rs36215820; rs35081782; rs35178191; rs13447446; rs2069826; rs34328912; rs3087224; rs36215821; rs4335044; rs36215822; rs11973115; rs36215817; rs11445458; rs34224237; rs36215461; rs36215818; rs34280821; rs34012176; rs34709428; rs10242595; rs10499563; rs11766273; rs12700386; rs12700390; rs13438415; rs1546762; rs1546763; rs17147230; rs1880241; rs1880242; rs1880243; rs2069852; rs2069853; rs2069854; rs2069855; rs2069862; rs3087221; rs3087238; rs35610689; rs4398801; rs4719713; rs4719714; rs6461662; rs6946908; rs6963444; rs6963591; rs7458109; rs7784987; rs7801617; rs7805828; rs940367

# Macromolecular_Interacting_Partner_4_General_References:
3491322; 3500852; 3538015; 3023045; 3320204; 2789513; 3758081; 3266463; 1291290; 3279116; 2610854; 1883960; 7851440; 2472117; 2037043; 8555185; 9159484; 9118960

# Macromolecular_Interacting_Partner_4_References:
12637250; 12819385; 12963019; 15284182

# Macromolecular_Interacting_Partner_5_ID:
7571

# Macromolecular_Interacting_Partner_5_Name:
Intercellular adhesion molecule 1 precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
ICAM-1; Major group rhinovirus receptor; CD54 antigen

# Macromolecular_Interacting_Partner_5_Gene_Name:
ICAM1

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Intercellular adhesion molecule 1 precursor
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGI
ETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAP
LPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHH
GANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLD
GLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQE
TLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKA
TPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQ
AWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYE
IVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
532

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
57826

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
8.06

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular process
Process:  cell adhesion
Process:  cell-cell adhesion
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
ICAM proteins are ligands for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2)

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF03921:ICAM_N

# Macromolecular_Interacting_Partner_5_Signals:
1-27

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
481-503

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
758074

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
ICAM1_HUMAN (P05362)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
ICAM1

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
ICAM1

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:5344

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1599 bp
ATGGCTCCCAGCAGCCCCCGGCCCGCGCTGCCCGCACTCCTGGTCCTGCTCGGGGCTCTG
TTCCCAGGACCTGGCAATGCCCAGACATCTGTGTCCCCCTCAAAAGTCATCCTGCCCCGG
GGAGGCTCCGTGCTGGTGACATGCAGCACCTCCTGTGACCAGCCCAAGTTGTTGGGCATA
GAGACCCCGTTGCCTAAAAAGGAGTTGCTCCTGCCTGGGAACAACCGGAAGGTGTATGAA
CTGAGCAATGTGCAAGAAGATAGCCAACCAATGTGCTATTCAAACTGCCCTGATGGGCAG
TCAACAGCTAAAACCTTCCTCACCGTGTACTGGACTCCAGAACGGGTGGAACTGGCACCC
CTCCCCTCTTGGCAGCCAGTGGGCAAGAACCTTACCCTACGCTGCCAGGTGGAGGGTGGG
GCACCCCGGGCCAACCTCACCGTGGTGCTGCTCCGTGGGGAGAAGGAGCTGAAACGGGAG
CCAGCTGTGGGGGAGCCCGCTGAGGTCACGACCACGGTGCTGGTGAGGAGAGATCACCAT
GGAGCCAATTTCTCGTGCCGCACTGAACTGGACCTGCGGCCCCAAGGGCTGGAGCTGTTT
GAGAACACCTCGGCCCCCTACCAGCTCCAGACCTTTGTCCTGCCAGCGACTCCCCCACAA
CTTGTCAGCCCCCGGGTCCTAGAGGTGGACACGCAGGGGACCGTGGTCTGTTCCCTGGAC
GGGCTGTTCCCAGTCTCGGAGGCCCAGGTCCACCTGGCACTGGGGGACCAGAGGTTGAAC
CCCACAGTCACCTATGGCAACGACTCCTTCTCGGCCAAGGCCTCAGTCAGTGTGACCGCA
GAGGACGAGGGCACCCAGCGGCTGACGTGTGCAGTAATACTGGGGAACCAGAGCCAGGAG
ACACTGCAGACAGTGACCATCTACAGCTTTCCGGCGCCCAACGTGATTCTGACGAAGCCA
GAGGTCTCAGAAGGGACCGAGGTGACAGTGAAGTGTGAGGCCCACCCTAGAGCCAAGGTG
ACGCTGAATGGGGTTCCAGCCCAGCCACTGGGCCCGAGGGCCCAGCTCCTGCTGAAGGCC
ACCCCAGAGGACAACGGGCGCAGCTTCTCCTGCTCTGCAACCCTGGAGGTGGCCGGCCAG
CTTATACACAAGAACCAGACCCGGGAGCTTCGTGTCCTGTATGGCCCCCGACTGGACGAG
AGGGATTGTCCGGGAAACTGGACGTGGCCAGAAAATTCCCAGCAGACTCCAATGTGCCAG
GCTTGGGGGAACCCATTGCCCGAGCTCAAGTGTCTAAAGGATGGCACTTTCCCACTGCCC
ATCGGGGAATCAGTGACTGTCACTCGAGATCTTGAGGGCACCTACCTCTGTCGGGCCAGG
AGCACTCAAGGGGAGGTCACCCGCGAGGTGACCGTGAATGTGCTCTCCCCCCGGTATGAG
ATTGTCATCATCACTGTGGTAGCAGCCGCAGTCATAATGGGCACTGCAGGCCTCAGCACG
TACCTCTATAACCGCCAGCGGAAGATCAAGAAATACAGACTACAACAGGCCCAAAAAGGG
ACCCCCATGAAACCGAACACACAAGCCACGCCTCCCTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
X06990

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_5_Locus:
19p13.3-p13.2

# Macromolecular_Interacting_Partner_5_SNPs:
rs5491; rs1801714; rs5497; rs1799969; rs5494; rs5493; rs5030381; rs13306429; rs35956512; rs5490; rs13306427; rs36086415; rs281433; rs5030377; rs281432; rs281431; rs5030348; rs281430; rs5030351; rs5030362; rs5030352; rs5030340; rs5030370; rs3093035; rs5030391; rs5030365; rs5030347; rs5496; rs281434; rs281428; rs5030354; rs5030364; rs12462944; rs5030395; rs281429; rs5030368; rs5030393; rs11667983; rs5030380; rs5030343; rs5030398; rs5030376; rs5030353; rs5030366; rs5030367; rs11879117; rs5030341; rs5030344; rs5030356; rs5030397; rs5030346; rs12459133; rs3093033; rs5030390; rs2358581; rs5030379; rs7258215; rs5030339; rs5030388; rs5030386; rs35501657; rs422429; rs13306430; rs5495; rs34369517; rs5492; rs2071441; rs372336; rs1800019; rs41520346; rs41276880; rs5030363; rs35769997; rs35660845; rs5030355; rs5030349; rs5030345; rs5030392; rs5030374; rs11575070; rs33958632; rs34542691; rs5030394; rs41360047; rs34215251; rs35590890; rs34434348; rs5030361; rs5030357; rs5030378; rs13306428; rs3073809; rs5030371; rs11575071; rs5030359; rs5030369; rs35871840; rs5030360; rs5030358; rs5827095; rs28432861; rs10420063; rs5030342; rs5030350; rs5030396; rs5030372; rs5030375; rs5030399; rs34496081; rs11575072; rs5030387; rs35643518; rs36213467; rs34546385; rs34876098; rs36213469; rs41468345; rs10402760; rs1056536; rs1056538; rs1057981; rs11575074; rs11669397; rs12972990; rs17852402; rs2071440; rs2075741; rs2075742; rs2228615; rs2569693; rs2569694; rs2569695; rs2569697; rs2569698; rs2569700; rs2569701; rs2569702; rs2569703; rs2569704; rs2569706; rs2569708; rs2735439; rs2735440; rs2735442; rs281437; rs281438; rs281439; rs281440; rs2916058; rs2916060; rs3093030; rs3093032; rs34918248; rs35318566; rs36045754; rs3810159; rs5030384; rs5030385; rs5030400; rs5499; rs5501; rs710845; rs735747; rs885743; rs901886

# Macromolecular_Interacting_Partner_5_General_References:
3340213; 3349522; 2544880; 1680919; 1983003; 2538243; 9539702; 9539703; 10562537; 7525451; 8557254; 9259284; 10391210

# Macromolecular_Interacting_Partner_5_References:
12914760; 15068815; 16496611

# Macromolecular_Interacting_Partner_6_ID:
6105

# Macromolecular_Interacting_Partner_6_Name:
Glutathione S-transferase A2

# Macromolecular_Interacting_Partner_6_Synonyms:
GTH2; HA subunit 2; GST- gamma; GSTA2-2; GST class-alpha member 2

# Macromolecular_Interacting_Partner_6_Gene_Name:
GSTA2

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Glutathione Stransferase A2
MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKEKALIDMYIEGIADLGEMILLLPFSQPEEQDAK
LALIQEKTKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEESRKIFRF

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
222

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
25664

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
9.07

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  glutathione transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

# Macromolecular_Interacting_Partner_6_Pathway:
map00480  Glutathione metabolism

# Macromolecular_Interacting_Partner_6_Reaction:
RX + glutathione = HX + R-S-glutathione

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
EC 2.5.1.18

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
306811

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
GSTA2_HUMAN (P09210)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
GSTA2

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
GSTA2

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:4627

# Macromolecular_Interacting_Partner_6_PDB_ID:
1AGS

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>669 bp
ATGGCAGAGAAGCCCAAGCTCCACTACTCCAATATACGGGGCAGAATGGAGTCCATCCGG
TGGCTCCTGGCTGCAGCTGGAGTAGAGTTTGAAGAGAAATTTATAAAATCTGCAGAAGAT
TTGGACAAGTTAAGAAATGATGGATATTTGATGTTCCAGCAAGTGCCAATGGTTGAGATT
GATGGGATGAAGCTGGTGCAGACCAGAGCCATTCTCAACTACATTGCCAGCAAATACAAC
CTCTATGGGAAAGACATAAAGGAGAAAGCCCTGATTGATATGTATATAGAAGGTATAGCA
GATTTGGGTGAAATGATCCTTCTTCTGCCCTTTACTCAACCTGAGGAACAAGATGCCAAG
CTTGCCTTGATCCAAGAGAAAACAAAAAATCGCTACTTCCCTGCCTTTGAAAAAGTCTTA
AAGAGCCACGGACAAGACTACCTTGTTGGCAACAAGCTGAGCCGGGCTGACATTCACCTG
GTGGAACTTCTCTACTACGTGGAAGAGCTTGACTCTAGCCTTATTTCCAGCTTCCCTCTG
CTGAAGGCCCTGAAAACCAGAATCAGTAACCTGCCCACAGTGAAGAAGTTTCTACAGCCT
GGCAGCCCAAGGAAGCCTCCCATGGATGAGAAATCTTTAGAAGAATCAAGGAAGATTTTC
AGGTTTTAA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
M16594

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_6_Locus:
6p12.1

# Macromolecular_Interacting_Partner_6_SNPs:
Not Available

# Macromolecular_Interacting_Partner_6_General_References:
3036131; 1329668; 1497629; 14574404; 8431482; 2604726; 11668220

# Macromolecular_Interacting_Partner_6_References:
15870871; 16133571; 16213016

# Macromolecular_Interacting_Partner_7_ID:
5331

# Macromolecular_Interacting_Partner_7_Name:
Alkaline phosphatase, placental-like precursor

# Macromolecular_Interacting_Partner_7_Synonyms:
Alkaline phosphatase Nagao isozyme; Germ-cell alkaline phosphatase; GCAP; PLAP-like; ALP-1

# Macromolecular_Interacting_Partner_7_Gene_Name:
ALPPL2

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Alkaline phosphatase, placentallike precursor
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLG
DGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLC
GVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDY
SQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRD
STLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERA
GQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL
KDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHV
MAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
532

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
57378

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.31

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_7_Specific_Function:
A phosphate monoester + H(2)O = an alcohol + phosphate

# Macromolecular_Interacting_Partner_7_Pathway:
map00361  gamma-Hexachlorocyclohexane degradation;
 map00790  Folate biosynthesis

# Macromolecular_Interacting_Partner_7_Reaction:
A phosphate monoester + H2O = an alcohol + phosphate

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00245:Alk_phosphatase

# Macromolecular_Interacting_Partner_7_Signals:
1-19

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
EC 3.1.3.1

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
178428

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
PPBN_HUMAN (P10696)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
ALPPL2

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
ALPPL2

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:441

# Macromolecular_Interacting_Partner_7_PDB_ID:
1EW2

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1599 bp
ATGCAGGGGCCCTGGGTGCTGCTCCTGCTGGGCCTGAGGCTACAGCTCTCCCTGGGCATC
ATCCCAGTTGAGGAGGAGAACCCGGACTTCTGGAACCGCCAGGCAGCCGAGGCCCTGGGT
GCCGCCAAGAAGCTGCAGCCTGCACAGACAGCCGCCAAGAACCTCATCATGTTCCTGGGT
GACGGGATGGGGGTGTCTACGGTGACAGCTGCCAGGATCCTAAAAGGGCAGAAGAAGGAC
AAACTGGGGCCTGAGACCTTCCTGGCCATGGACCGCTTCCCGTACGTGGCTCTGTCCAAG
ACATACAGTGTAGACAAGCATGTGCCAGACAGTGGAGCCACAGCCACGGCCTACCTGTGC
GGGGTCAAGGGCAACTTCCAGACCATTGGCTTGAGTGCAGCCGCCCGCTTTAACCAGTGC
AACACGACACGCGGCAACGAGGTCATCTCCGTGGTGAATCGGGCCAAGAAAGCAGGAAAG
TCAGTGGGAGTGGTAACCACCACACGGGTGCAGCATGCCTCGCCAGCCGGCACCTACGCC
CACACGGTGAACCGCAACTGGTACTCGGATGCCGACGTGCCTGCCTCGGCCCGCCAGGAG
GGGTGCCAGGACATCGCCACGCAGCTCATCTCCAACATGGACATTGATGTGATCCTAGGT
GGAGGCCGAAAGTACATGTTTCCCATGGGGACCCCAGACCCTGAGTACCCAGATGACTAC
AGCCAAGGTGGGACCAGGCTGGACGGGAAGAATCTGGTGCAGGAATGGCTGGCGAAGCAC
CAGGGTGCCCGGTACGTGTGGAACCGCACTGAGCTCCTGCAGGCTTCCCTGGACCCGTCT
GTGACCCATCTCATGGGTCTCTTTGAGCCTGGAGACATGAAATACGAGATCCACCGAGAC
TCCACACTGGACCCCTCCCTGATGGAGATGACAGAGGCTGCCCTGCTCCTGCTGAGCAGG
AACCCCCGCGGCTTCTTCCTCTTCGTGGAGGGTGGTCGCATCGACCATGGTCATCATGAA
AGCAGGGCTTACCGGGCACTGACTGAGACGATCATGTTCGACGACGCCATTGAGAGGGCG
GGCCAGCTCACCAGCGAGGAGGACACGCTGAGCCTCGTCACTGCCGACCACTCCCACGTC
TTCTCCTTCGGAGGCTACCCCCTGCGAGGGAGCTCCATCTTCGGGCTGGCCCCTGGCAAG
GCCCGGGACAGGAAGGCCTACACGGTCCTCCTATACGGAAACGGTCCAGGCTATGTGCTC
AAGGACGGCGCCCGGCCGGATGTTACGGAGAGCGAGAGCGGGAGCCCCGAGTATCGGCAG
CAGTCAGCAGTGCCCCTGGACGGAGAGACCCACGCAGGCGAGGACGTGGCGGTGTTCGCG
CGCGGCCCGCAGGCGCACCTGGTTCACGGCGTGCAGGAGCAGACCTTCATAGCGCACGTC
ATGGCCTTCGCCGCCTGCCTGGAGCCCTACACCGCCTGCGACCTGGCGCCCCCCGCCGGC
ACCACCGACGCCGCGCACCCGGGGCCGTCCGTGGTCCCCGCGTTGCTTCCTCTGCTGGCA
GGGACCTTGCTGCTGCTGGGGACGGCCACTGCTCCCTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
J03252

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_7_Locus:
2q37

# Macromolecular_Interacting_Partner_7_SNPs:
rs1048983; rs1048999; rs17416141; rs2090543; rs1048997; rs1009934; rs2678519; rs2697781; rs3828248; rs3828254; rs2697767; rs3828249; rs2697768; rs1048995; rs16836187; rs3116148; rs1130334; rs41265119; rs41265117; rs3111340; rs41265115; rs1049002; rs1049001; rs3189080; rs3924351; rs1049003; rs1130348; rs1130351; rs3924352; rs3189077; rs6728119; rs2091555; rs2945420; rs2678518; rs41265113; rs3111339; rs3833560; rs2678517; rs2945421; rs41265111; rs2091556; rs3830644; rs3828251; rs3828253; rs2697769; rs11363206; rs3828250; rs3828252; rs11678251; rs1001868; rs10195918; rs13002718; rs13003189; rs13412526; rs1878691; rs2082841; rs2082842; rs2139026; rs2139027; rs2573208; rs2573209; rs2697766; rs2697790; rs2697791; rs2697792; rs2697793; rs2741321; rs2853380; rs732581; rs744873; rs744874; rs790050; rs790051

# Macromolecular_Interacting_Partner_7_General_References:
2834730; 2745460; 2297757; 2162249; 3387245

# Macromolecular_Interacting_Partner_7_References:
15703838; 16465285; 17084582

# Macromolecular_Interacting_Partner_8_ID:
7599

# Macromolecular_Interacting_Partner_8_Name:
Proliferating cell nuclear antigen

# Macromolecular_Interacting_Partner_8_Synonyms:
PCNA; Cyclin

# Macromolecular_Interacting_Partner_8_Gene_Name:
PCNA

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Proliferating cell nuclear antigen
MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTY
RCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMD
LDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNI
KLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYK
IADMGHLKYYLAPKIEDEEGS

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
261

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
28769

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
4.31

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed DNA polymerase activity
Function:  DNA polymerase processivity factor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of DNA metabolism
Process:  regulation of DNA replication
 ||
>>>
Component:  protein complex
Component:  delta-DNA polymerase cofactor complex
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_8_General_Function:
Replication, recombination and repair 

# Macromolecular_Interacting_Partner_8_Specific_Function:
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF02747:PCNA_C;
PF00705:PCNA_N

# Macromolecular_Interacting_Partner_8_Signals:
None

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
181272

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
PCNA_HUMAN (P12004)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
PCNA

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
PCNA

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:8729

# Macromolecular_Interacting_Partner_8_PDB_ID:
1U76

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>786 bp
ATGTTCGAGGCGCGCCTGGTCCAGGGCTCCATCCTCAAGAAGGTGTTGGAGGCACTCAAG
GACCTCATCAACGAGGCCTGCTGGGATATTAGCTCCAGCGGTGTAAACCTGCAGAGCATG
GACTCGTCCCACGTCTCTTTGGTGCAGCTCACCCTGCGGTCTGAGGGCTTCGACACCTAC
CGCTGCGACCGCAACCTGGCCATGGGCGTGAACCTCACCAGTATGTCCAAAATACTAAAA
TGCGCCGGCAATGAAGATATCATTACACTAAGGGCCGAAGATAACGCGGATACCTTGGCG
CTAGTATTTGAAGCACCAAACCAGGAGAAAGTTTCAGACTATGAAATGAAGTTGATGGAT
TTAGATGTTGAACAACTTGGAATTCCAGAACAGGAGTACAGCTGTGTAGTAAAGATGCCT
TCTGGTGAATTTGCACGTATATGCCGAGATCTCAGCCATATTGGAGATGCTGTTGTAATT
TCCTGTGCAAAAGACGGAGTGAAATTTTCTGCAAGTGGAGAACTTGGAAATGGAAACATT
AAATTGTCACAGACAAGTAATGTCGATAAAGAGGAGGAAGCTGTTACCATAGAGATGAAT
GAACCAGTTCAACTAACTTTTGCACTGAGGTACCTGAACTTCTTTACAAAAGCCACTCCA
CTCTCTTCAACGGTGACACTCAGTATGTCTGCAGATGTACCCCTTGTTGTAGAGTATAAA
ATTGCGGATATGGGACACTTAAAATACTACTTGGCTCCCAAGATCGAGGATGAAGAAGGA
TCTTAG

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
M15796

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_8_Locus:
20pter-p12

# Macromolecular_Interacting_Partner_8_SNPs:
rs17350; rs17353; rs3730415; rs3626; rs8632; rs3730416; rs3730414; rs6116655; rs6116656; rs34818603; rs3730417; rs3730428; rs3730426; rs17352; rs25405; rs17347; rs17351; rs3730441; rs3730436; rs3730438; rs25406; rs17349; rs3730434; rs3730423; rs3730435; rs3730433; rs3730440; rs17348; rs3730431; rs3730427; rs3730424; rs3730437; rs3730425; rs1050525; rs36228623; rs35106260; rs11482829; rs11700149; rs10712799; rs34987280; rs10712798; rs36228616; rs34188898; rs34672771; rs11469817; rs6139626; rs6139627; rs7263456; rs11543929; rs36228622; rs6139628; rs36228617; rs36228618; rs11481769; rs35623151; rs3730432; rs35240308; rs35258130; rs6139625; rs6107578; rs3730439; rs13037111; rs16990612; rs2083918; rs2423089; rs261345; rs3729558; rs3730445; rs3730446; rs3730447; rs3730448; rs3730449; rs3730450; rs3730453; rs3730455; rs3730456; rs3761241; rs4239761; rs6053127; rs6107576; rs6107577; rs6107581; rs6116651; rs6116652; rs6116653; rs6116654; rs6139624; rs6139635; rs7264821; rs7344137; rs8122586; rs8124482; rs8125170

# Macromolecular_Interacting_Partner_8_General_References:
2882507; 2565339; 11780052; 2882422; 9305916; 9302295; 11376153; 11784855; 12522211; 8861913

# Macromolecular_Interacting_Partner_8_References:
16007142; 16160080

# Macromolecular_Interacting_Partner_9_ID:
6443

# Macromolecular_Interacting_Partner_9_Name:
Proto-oncogene tyrosine-protein kinase Src

# Macromolecular_Interacting_Partner_9_Synonyms:
p60-Src; c- Src; pp60c-src

# Macromolecular_Interacting_Partner_9_Gene_Name:
SRC

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Protooncogene tyrosineprotein kinase Src
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
536

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
59835

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
7.47

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  protein-tyrosine kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF07714:Pkinase_Tyr;
PF00017:SH2;
PF00018:SH3_1

# Macromolecular_Interacting_Partner_9_Signals:
None

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
EC 2.7.10.2

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
10635153

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
SRC_HUMAN (P12931)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
SRC

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
SRC

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:11283

# Macromolecular_Interacting_Partner_9_PDB_ID:
2SRC

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>1629 bp
ATGGGTAGCAACAAGAGCAAGCCCAAGGATGCCAGCCAGCGGCGCCGCAGCCTGGAGCCC
GCCGAGAACGTGCACGGCGCTGGCGGGGGCGCTTTCCCCGCCTCGCAGACCCCCAGCAAG
CCAGCCTCGGCCGACGGCCACCGCGGCCCCAGCGCGGCCTTCGCCCCCGCGGCCGCCGAG
CCCAAGCTGTTCGGAGGCTTCAACTCCTCGGACACCGTCACCTCCCCGCAGAGGGCGGGC
CCGCTGGCCGGTGGAGTGACCACCTTTGTGGCCCTCTATGACTATGAGTCTAGGACGGAG
ACAGACCTGTCCTTCAAGAAAGGCGAGCGGCTCCAGATTGTCAACAACACGAGGAAGGTG
GATGTCAGAGAGGGAGACTGGTGGCTGGCCCACTCGCTCAGCACAGGACAGACAGGCTAC
ATCCCCAGCAACTACGTGGCGCCCTCCGACTCCATCCAGGCTGAGGAGTGGTATTTTGGC
AAGATCACCAGACGGGAGTCAGAGCGGTTACTGCTCAATGCAGAGAACCCGAGAGGGACC
TTCCTCGTGCGAGAAAGTGAGACCACGAAAGGTGCCTACTGCCTCTCAGTGTCTGACTTC
GACAACGCCAAGGGCCTCAACGTGAAGCACTACAAGATCCGCAAGCTGGACAGCGGCGGC
TTCTACATCACCTCCCGCACCCAGTTCAACAGCCTGCAGCAGCTGGTGGCCTACTACTCC
AAACACGCCGATGGCCTGTGCCACCGCCTCACCACCGTGTGCCCCACGTCCAAGCCGCAG
ACTCAGGGCCTGGCCAAGGATGCCTGGGAGATCCCTCGGGAGTCGCTGCGGCTGGAGGTC
AAGCTGGGCCAGGGCTGCTTTGGCGAGGTGTGGATGGGGACCTGGAACGGTACCACCAGG
GTGGCCATCAAAACCCTGAAGCCTGGCACGATGTCTCCAGAGGCCTTCCTGCAGGAGGCC
CAGGTCATGAAGAAGCTGAGGCATGAGAAGCTGGTGCAGTTGTATGCTGTGGTTTCAGAG
GAGCCCATTTACATCGTCACGGAGTACATGAGCAAGGGGAGTTTGCTGGACTTTCTCAAG
GGGGAGACAGGCAAGTACCTGCGGCTGCCTCAGCTGGTGGACATGGCTGCTCAGATCGCC
TCAGGCATGGCGTACGTGGAGCGGATGAACTACGTCCACCGGGACCTTCGTGCAGCCAAC
ATCCTGGTGGGAGAGAACCTGGTGTGCAAAGTGGCGGACTTTGGGCTGGCTCGGCTCATT
GAAGACAATGAGTACACGGCGCGGCAAGGTGCCAAATTCCCCATCAAGTGGACGGCTCCA
GAAGCTGCCCTCTATGGCCGCTTCACCATCAAGTCGGACGTGTGGTCCTTCGGGATCCTG
CTGACTGAGCTCACCACAAAGGGACGGGTGCCCTACCCTGGGATGGTGAACCGCGAGGTG
CTGGACCAGGTGGAGCGGGGCTACCGGATGCCCTGCCCGCCGGAGTGTCCCGAGTCCCTG
CACGACCTCATGTGCCAGTGCTGGCGGAAGGAGCCTGAGGAGCGGCCCACCTTCGAGTAC
CTGCAGGCCTTCCTGGAGGACTACTTCACGTCCACCGAGCCCCAGTACCAGCCCGGGGAG
AACCTCTAG

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
AL133293

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_9_Locus:
20q12-q13

# Macromolecular_Interacting_Partner_9_SNPs:
rs1885257; rs744285; rs6018000; rs6018156; rs6017996; rs12329503; rs6094509; rs6018027; rs7275012; rs8126089; rs6018088; rs911496; rs6018148; rs6018199; rs6018042; rs1547836; rs6018038; rs747182; rs6018161; rs11905180; rs11697568; rs12106024; rs6090573; rs16986606; rs6017944; rs6094508; rs8117415; rs6063022; rs17785475; rs6018031; rs12480646; rs3762203; rs6012089; rs11905079; rs1547837; rs11908679; rs6063029; rs3940202; rs6090575; rs6094425; rs11907753; rs17787897; rs11906741; rs6012064; rs6066129; rs17194717; rs3762205; rs11697215; rs6090585; rs6018140; rs11904904; rs6018107; rs7269342; rs6017943; rs6018091; rs6011996; rs6018131; rs6018153; rs6017962; rs6018154; rs6017938; rs6018128; rs11908137; rs6090529; rs12479921; rs7347850; rs11908547; rs6090576; rs1573162; rs6018284; rs6018257; rs6018256; rs1570209; rs6124933; rs754625; rs11906658; rs8120573; rs6018246; rs6018233; rs2273677; rs3790149; rs10854173; rs754626; rs6018290; rs6012117; rs12233271; rs6090599; rs3790150; rs6124914; rs6017916; rs6017917; rs6017919; rs7273386; rs6011987; rs35093452; rs6018260; rs34881773; rs13036519; rs6018259; rs6018100; rs11483840; rs6094386; rs6122526; rs34905200; rs6018208; rs10535931; rs6018114; rs6066069; rs6090528; rs11468816; rs6018138; rs36003615; rs6018207; rs6094417; rs6090530; rs35008342; rs11470839; rs6124957; rs11472640; rs6018046; rs6124899; rs35931930; rs34256652; rs6122523; rs35987579; rs35694770; rs11470429; rs34071321; rs35475646; rs11470840; rs6090527; rs6090521; rs35624849; rs35282943; rs6011991; rs11479944; rs6090579; rs6094421; rs12106037; rs6017997; rs12481364; rs6066087; rs41282798; rs34939572; rs6018191; rs11450067; rs6090580; rs34795353; rs6094413; rs6090526; rs6018003; rs6094476; rs7352195; rs11086198; rs35472502; rs35466362; rs35522786; rs6066139; rs6090522; rs6066074; rs4810567; rs6017991; rs33975289; rs6124884; rs3762206; rs6018074; rs8125374; rs36113326; rs35074236; rs3762207; rs11472642; rs6090577; rs7348051; rs6066073; rs11473947; rs6094412; rs6018189; rs6066037; rs35623563; rs3078007; rs6094475; rs35528854; rs34660457; rs6066048; rs6018083; rs5841263; rs7345405; rs35422797; rs13036724; rs8117148; rs6017971; rs34916450; rs6012058; rs11697728; rs7264770; rs6066140; rs36208532; rs6017990; rs6066038; rs35784949; rs35731780; rs6094491; rs6066028; rs41282796; rs6094387; rs11467467; rs35547944; rs35732924; rs35446893; rs13043913; rs4809610; rs6063072; rs28763883; rs13039797; rs35489398; rs6124920; rs3827968; rs4810601; rs4809611; rs13043912; rs33973567; rs6124911; rs2295747; rs11475404; rs6018224; rs8115993; rs6018255; rs13038224; rs11479945; rs6122545; rs35311974; rs6066167; rs6066215; rs33926499; rs6018236; rs10714592; rs33965411; rs6018254; rs6094563; rs11467123; rs6018273; rs6124932; rs11086187; rs6094579; rs35223630; rs11474889; rs6066155; rs28763884; rs2145792; rs4810600; rs35480354; rs28763882; rs4810582; rs35182938; rs34190038; rs6063004; rs35683688; rs6094378; rs11427827; rs35612430; rs10084513; rs10084517; rs11697275; rs11905013; rs11908417; rs11908486; rs16986596; rs16986599; rs4809629; rs4810624; rs6011973; rs6017880; rs6017882; rs6017889; rs6017901; rs6017913; rs6018348; rs6018387; rs6018390; rs6018391; rs6094357; rs6094358; rs6094363; rs6094373; rs6094643; rs6122566; rs6124810; rs7272779; rs8114109; rs8117951; rs8118277; rs8118377

# Macromolecular_Interacting_Partner_9_General_References:
11780052; 3299057; 2582238; 2681803; 2581127; 12415108; 9024657; 9174343; 7532003

# Macromolecular_Interacting_Partner_9_References:
16001424; 16094635

# Macromolecular_Interacting_Partner_10_ID:
7612

# Macromolecular_Interacting_Partner_10_Name:
Vascular endothelial growth factor A precursor

# Macromolecular_Interacting_Partner_10_Synonyms:
VEGF-A; Vascular permeability factor; VPF

# Macromolecular_Interacting_Partner_10_Gene_Name:
VEGF

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Vascular endothelial growth factor A precursor
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD
IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM
SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPG
PHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
232

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
27043

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
9.08

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00341:PDGF

# Macromolecular_Interacting_Partner_10_Signals:
1-26

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
181971

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
VEGFA_HUMAN (P15692)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
VEGF

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
VEGF

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:12680

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Secreted protein. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell- associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>576 bp
ATGAACTTTCTGCTGTCTTGGGTGCATTGGAGCCTCGCCTTGCTGCTCTACCTCCACCAT
GCCAAGTGGTCCCAGGCTGCACCCATGGCAGAAGGAGGAGGGCAGAATCATCACGAAGTG
GTGAAGTTCATGGATGTCTATCAGCGCAGCTACTGCCATCCAATCGAGACCCTGGTGGAC
ATCTTCCAGGAGTACCCTGATGAGATCGAGTACATCTTCAAGCCATCCTGTGTGCCCCTG
ATGCGATGCGGGGGCTGCTGCAATGACGAGGGCCTGGAGTGTGTGCCCACTGAGGAGTCC
AACATCACCATGCAGATTATGCGGATCAAACCTCACCAAGGCCAGCACATAGGAGAGATG
AGCTTCCTACAGCACAACAAATGTGAATGCAGACCAAAGAAAGATAGAGCAAGACAAGAA
AATCCCTGTGGGCCTTGCTCAGAGCGGAGAAAGCATTTGTTTGTACAAGATCCGCAGACG
TGTAAATGTTCCTGCAAAAACACAGACTCGCGTTGCAAGGCGAGGCAGCTTGAGTTAAAC
GAACGTACTTGCAGATGTGACAAGCCGAGGCGGTGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
M32977

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_10_Locus:
6p12

# Macromolecular_Interacting_Partner_10_SNPs:
Not Available

# Macromolecular_Interacting_Partner_10_General_References:
2479986; 2479987; 1711045; 1791831; 1567395; 9054410; 9878851; 9450968; 10464055; 14574404; 7678805; 2584205; 10067980; 9207067; 9351807; 9922142; 9336848; 9634701; 11427521

# Macromolecular_Interacting_Partner_10_References:
12622137; 14596920; 16105646

# Macromolecular_Interacting_Partner_11_ID:
7058

# Macromolecular_Interacting_Partner_11_Name:
CD44 antigen precursor

# Macromolecular_Interacting_Partner_11_Synonyms:
Phagocytic glycoprotein I; PGP-1; HUTCH-I; Extracellular matrix receptor-III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; Hermes antigen; Hyaluronate receptor; Heparan sulfate proteoglycan; Epican; CDw44

# Macromolecular_Interacting_Partner_11_Gene_Name:
CD44

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>CD44 antigen precursor
MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTL
PTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFN
ASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSS
GSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQE
TWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDD
EDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWN
PEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPREDS
HSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSTT
LQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDV
TGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNR
SLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLAL
ALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSET
PDQFMTADETRNLQNVDMKIGV

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
742

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
81554

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
5.00

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  binding
Function:  pattern binding
Function:  polysaccharide binding
Function:  glycosaminoglycan binding
Function:  hyaluronic acid binding
 ||
>>>
Process:  cellular process
Process:  cell adhesion
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_11_General_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Specific_Function:
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF00193:Xlink

# Macromolecular_Interacting_Partner_11_Signals:
1-20

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
650-670

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
180197

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
CD44_HUMAN (P16070)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
CD44

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
CD44

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:1681

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>1086 bp
ATGGACAAGTTTTGGTGGCACGCAGCCTGGGGACTCTGCCTCGTGCCGCTGAGCCTGGCG
CAGATCGATTTGAATATAACCTGCCGCTTTGCAGGTGTATTCCACGTGGAGAAAAATGGT
CGCTACAGCATCTCTCGGACGGAGGCCGCTGACCTCTGCAAGGCTTTCAATAGCACCTTG
CCCACAATGGCCCAGATGGAGAAAGCTCTGAGCATCGGATTTGAGACCTGCAGGTATGGG
TTCATAGAAGGGCATGTGGTGATTCCCCGGATCCACCCCAACTCCATCTGTGCAGCAAAC
AACACAGGGGTGTACATCCTCACATACAACACCTCCCAGTATGACACATATTGCTTCAAT
GCTTCAGCTCCACCTGAAGAAGATTGTACATCAGTCACAGACCTGCCCAATGCCTTTGAT
GGACCAATTACCATAACTATTGTTAACCGTGATGGCACCCGCTATGTCCAGAAAGGAGAA
TACAGAACGAATCCTGAAGACATCTACCCCAGCAACCCTACTGATGATGACGTGAGCAGC
GGCTCCTCCAGTGAAAGGAGCAGCACTTCAGGAGGTTACATCTTTTACACCTTTTCTACT
GTACACCCCATCCCAGACGAAGACAGTCCCTGGATCACCGACAGCACAGACAGAATCCCT
GCTACCAGAGACCAAGACACATTCCACCCCAGTGGGGGGTCCCATACCACTCATGAATCT
GAATCAGATGGACACTCACATGGGAGTCAAGAAGGTGGAGCAAACACAACCTCTGGTCCT
ATAAGGACACCCCAAATTCCAGAATGGCTGATCATCTTGGCATCCCTCTTGGCCTTGGCT
TTGATTCTTGCAGTTTGCATTGCAGTCAACAGTCGAAGAAGGTGTGGGCAGAAGAAAAAG
CTAGTGATCAACAGTGGCAATGGAGCTGTGGAGGACAGAAAGCCAAGTGGACTCAACGGA
GAGGCCAGCAAGTCTCAGGAAATGGTGCATTTGGTGAACAAGGAGTCGTCAGAAACTCCA
GACCAGTTTATGACAGCTGATGAGACAAGGAACCTGCAGAATGTGGACATGAAGATTGGG
GTGTAA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
M24915

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_11_Locus:
11p13

# Macromolecular_Interacting_Partner_11_SNPs:
rs1467558; rs11607491; rs9666607; rs11033026; rs1071695; rs13347; rs10836347; rs8193; rs11821102; rs2295755; rs353558; rs353623; rs1547059; rs2295756; rs2421826; rs353627; rs932703; rs353615; rs353639; rs193276; rs353612; rs353630; rs927335; rs353629; rs353626; rs1425803; rs353620; rs353647; rs1547058; rs7934770; rs11607862; rs353642; rs3794109; rs353640; rs353634; rs10128562; rs7126359; rs996076; rs10836340; rs353632; rs353638; rs10836344; rs7105890; rs353628; rs7930549; rs353635; rs187115; rs7116739; rs10836343; rs2785172; rs7930724; rs4756195; rs353631; rs353617; rs353636; rs353618; rs102518; rs2553808; rs10128586; rs1547060; rs7110737; rs12419062; rs6484768; rs7116432; rs353643; rs353648; rs713330; rs3794105; rs2553809; rs353641; rs353646; rs16927009; rs10488810; rs4756199; rs16927100; rs3794110; rs7947433; rs2785171; rs17445923; rs10488809; rs353625; rs10488811; rs7938811; rs12577824; rs3794113; rs4755391; rs10836346; rs16927061; rs12270356; rs3736812; rs3751031; rs17375044; rs3794116; rs10836342; rs4756196; rs7945310; rs11033031; rs353644; rs2180974; rs12275533; rs12577007; rs7115768; rs17445972; rs187116; rs7937602; rs353645; rs353614; rs16926995; rs3794125; rs7952514; rs10734436; rs353633; rs112762; rs12280375; rs11822487; rs353637; rs2065006; rs4141971; rs2065004; rs11033013; rs3794107; rs10768114; rs11033021; rs353619; rs11033008; rs353624; rs2295758; rs9943592; rs16927029; rs353621; rs1981153; rs3794126; rs724474; rs7110710; rs11033019; rs1981154; rs7127087; rs3794104; rs11033010; rs7115434; rs7130549; rs6484770; rs12280381; rs12283855; rs353622; rs12420308; rs12575828; rs11820975; rs7105972; rs16926993; rs3829268; rs1474996; rs11033014; rs17446448; rs7928464; rs12272373; rs16927073; rs3794118; rs2421825; rs7932149; rs10836341; rs6484769; rs7947941; rs11033028; rs17447734; rs16927089; rs10836345; rs11033030; rs16927081; rs17447755; rs353613; rs7131335; rs11033033; rs12282190; rs7938147; rs7945284; rs919041; rs12288926; rs11033012; rs16927042; rs7952493; rs17367744; rs17446000; rs10742333; rs11605479; rs2065005; rs7934647; rs16927033; rs353616; rs7941924; rs12275472; rs6416081; rs1407822; rs3794108; rs12291025; rs11033024; rs996075; rs16926942; rs16927055; rs4141970; rs1570483; rs12362973; rs11033025; rs17367609; rs12291116; rs7111731; rs1407823; rs4755392; rs12575005; rs7944409; rs7111018; rs12273397; rs35963728; rs1058200; rs35498342; rs35911720; rs35356320; rs3198807; rs35608218; rs16927157; rs34137404; rs12293021; rs11384802; rs367229; rs2295757; rs3209774; rs5791040; rs17446427; rs11332184; rs16927120; rs35130248; rs7110041; rs11033029; rs3215691; rs36032428; rs34076207; rs12286019; rs7944818; rs11033023; rs12800786; rs35702928; rs34443928; rs374201; rs35860001; rs7952338; rs10560626; rs35747418; rs5791037; rs241494; rs34048081; rs16927093; rs2785190; rs5791042; rs35505196; rs3838798; rs12270112; rs11033020; rs3794106; rs33986625; rs7941598; rs5791039; rs35861024; rs11366759; rs724473; rs34823633; rs35437849; rs35459892; rs34853532; rs11033022; rs34175178; rs12796766; rs35501119; rs12804343; rs28454562; rs35796444; rs1065270; rs12278428; rs28675257; rs10675782; rs10610762; rs12277192; rs12285721; rs12796689; rs34932141; rs1764340; rs11607814; rs5791035; rs11340143; rs28741987; rs35650007; rs2421824; rs35464422; rs12800555; rs35605320; rs7121622; rs35792607; rs7484034; rs34784484; rs11605504; rs35043907; rs1050794; rs3047476; rs12574690; rs12795998; rs35740489; rs35334525; rs11448430; rs35138175; rs35429509; rs3829269; rs36022557; rs34848601; rs35313251; rs34187833; rs34623865; rs16927102; rs35800173; rs35978972; rs3047471; rs1321699; rs34146255; rs35941133; rs11033018; rs3047478; rs10567300; rs35342604; rs11033032; rs12785683; rs35599324; rs11428995; rs35863501; rs1885937; rs7131664; rs35302120; rs11033027; rs12365903; rs11382248; rs35217950; rs34948864; rs34453969; rs12365962; rs16927067; rs5791036; rs35852050; rs34182601; rs4141969; rs5791043; rs35914016; rs5791038; rs2295760; rs2273690; rs35414303; rs28582665; rs12791889; rs35087350; rs35953520; rs11478829; rs34292272; rs4756197; rs10718079; rs11378695; rs34207613; rs16926939; rs1186243; rs16926997; rs11600650; rs12290471; rs12365919; rs34808104; rs35251986; rs35343317; rs35040129; rs34986068; rs12577058; rs16927116; rs17445902; rs3838797; rs11825862; rs2295759; rs35251438; rs12421708; rs34847145; rs5791034; rs12796688; rs11323103; rs34837817; rs3829267; rs35112146; rs10488808; rs10488812; rs10742334; rs10742337; rs10768116; rs10768117; rs10836349; rs10836351; rs11033007; rs11033036; rs11033037; rs11822963; rs11826767; rs1425802; rs17449131; rs2180973; rs2257171; rs2732571; rs2732572; rs2732573; rs2785173; rs2785174; rs353559; rs353560; rs353566; rs353567; rs353569; rs353570; rs353571; rs395563; rs398734; rs4756193; rs4756200; rs4756201; rs598725; rs7104704; rs7105037; rs7105418; rs7105545; rs7114332; rs7115638; rs7119757; rs7122374; rs7124327; rs7934471

# Macromolecular_Interacting_Partner_11_General_References:
2466575; 1840487; 1991450; 2056274; 1281868; 1465456; 7508842; 8352881; 2466576; 2007624; 1717145; 8148709; 1922057; 9580567; 12883358; 8636151

# Macromolecular_Interacting_Partner_11_References:
15385498; 15746573; 16115366

# Macromolecular_Interacting_Partner_12_ID:
7615

# Macromolecular_Interacting_Partner_12_Name:
cAMP response element-binding protein

# Macromolecular_Interacting_Partner_12_Synonyms:
CREB

# Macromolecular_Interacting_Partner_12_Gene_Name:
CREB1

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>cAMP response elementbinding protein
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN
GQTVQVHGVIQAAQPSVIQSPQVQTVQSSCKDLKRLFSGTQISTIAESEDSQESVDSVTD
SQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSG
QYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQV
VVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAAREC
RRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
341

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
36688

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
5.24

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  protein binding
Function:  transcription factor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF00170:bZIP_1;
PF02173:pKID

# Macromolecular_Interacting_Partner_12_Signals:
None

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
240429

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
CREB1_HUMAN (P16220)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
CREB1

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
CREB1

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:2345

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>984 bp
ATGACCATGGAATCTGGAGCCGAGAACCAGCAGAGTGGAGATGCAGCTGTAACAGAAGCT
GAAAACCAACAAATGACAGTTCAAGCCCAGCCACAGATTGCCACATTAGCCCAGGTATCT
ATGCCAGCAGCTCATGCAACATCATCTGCTCCCACCGTAACTCTAGTACAGCTGCCCAAT
GGGCAGACAGTTCAAGTCCATGGAGTCATTCAGGCGGCCCAGCCATCAGTTATTCAGTCT
CCACAAGTCCAAACAGTTCAGATTTCAACTATTGCAGAAAGTGAAGATTCACAGGAGTCA
GTGGATAGTGTAACTGATTCCCAAAAGCGAAGGGAAATTCTTTCAAGGAGGCCTTCCTAC
AGGAAAATTTTGAATGACTTATCTTCTGATGCACCAGGAGTGCCAAGGATTGAAGAAGAG
AAGTCTGAAGAGGAGACTTCAGCACCTGCCATCACCACTGTAACGGTGCCAACTCCAATT
TACCAAACTAGCAGTGGACAGTATATTGCCATTACCCAGGGAGGAGCAATACAGCTGGCT
AACAATGGTACCGATGGGGTACAGGGCCTGCAAACATTAACCATGACCAATGCAGCAGCC
ACTCAGCCGGGTACTACCATTCTACAGTATGCACAGACCACTGATGGACAGCAGATCTTA
GTGCCCAGCAACCAAGTTGTTGTTCAAGCTGCCTCTGGAGACGTACAAACATACCAGATT
CGCACAGCACCCACTAGCACTATTGCCCCTGGAGTTGTTATGGCATCCTCCCCAGCACTT
CCTACACAGCCTGCTGAAGAAGCAGCACGAAAGAGAGAGGTCCGTCTAATGAAGAACAGG
GAAGCAGCTCGAGAGTGTCGTAGAAAGAAGAAAGAATATGTGAAATGTTTAGAAAACAGA
GTGGCAGTGCTTGAAAATCAAAACAAGACATTGATTGAGGAGCTAAAAGCACTTAAGGAC
CTTTACTGCCACAAATCAGATTAA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
S72459

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_12_Locus:
2q34

# Macromolecular_Interacting_Partner_12_SNPs:
rs2709357; rs2709356; rs889895; rs2551917; rs2709400; rs2551640; rs2709360; rs2042486; rs2551642; rs4675682; rs2709359; rs2551639; rs11883511; rs7590024; rs2709355; rs2551641; rs2709398; rs2360970; rs2042485; rs12466352; rs2709399; rs2709387; rs2551920; rs2551923; rs2464978; rs6740584; rs2254137; rs2551921; rs2551919; rs9679258; rs9288383; rs3770704; rs13397461; rs12694087; rs2551922; rs16839883; rs2194430; rs11904814; rs2709393; rs3730300; rs2247053; rs10199872; rs2551924; rs2551644; rs2059336; rs17811997; rs7603049; rs11692041; rs7570673; rs3730276; rs13393250; rs2551645; rs2709402; rs2709388; rs2464977; rs17515722; rs2551926; rs13398837; rs10932201; rs2952766; rs12477957; rs2709392; rs2464976; rs2551638; rs35349697; rs34884247; rs35342276; rs12992351; rs12467170; rs13422727; rs13016095; rs10561230; rs10202862; rs35952037; rs35924297; rs35303892; rs3836057; rs1050641; rs2709354; rs35153918; rs4024317; rs35539388; rs11356093; rs12998737; rs11397523; rs35506841; rs9677382; rs35379208; rs12992752; rs12470697; rs13029939; rs12467171; rs13422622; rs35711096; rs35714520; rs34172985; rs10598911; rs4024318; rs35004775; rs3836058; rs10568689; rs13422714; rs35282925; rs35047346; rs34797824; rs7582473; rs35896795; rs6729764; rs12614101; rs7603975; rs2709385; rs13018430; rs34411431; rs2709403; rs34628133; rs2551647; rs7589804; rs34775277; rs35762508; rs2551646; rs28853093; rs17515729; rs13431009; rs2551918; rs7558859; rs34583259; rs2551648; rs34550164; rs2551925; rs6715664; rs2709404; rs35735523; rs7576411; rs4101544; rs34903544; rs3951781; rs34242417; rs1064176; rs4675684; rs6705627; rs11311967; rs13412269; rs34309640; rs10185283; rs11684107; rs36108540; rs35955521; rs5838079; rs35019306; rs35728983; rs2709389; rs34275460; rs34379142; rs2709362; rs35000643; rs35261053; rs35119018; rs13409275; rs2709381; rs34177886; rs12478868; rs34145676; rs2709378; rs2551643; rs7588606; rs34127936; rs35865443; rs12998128; rs2709377; rs11319861; rs11335782; rs35907148; rs34317727; rs35318842; rs1045780; rs1045790; rs12999688; rs13029936; rs13386109; rs1806584; rs1806585; rs2551928; rs2551931; rs2709371; rs2709373; rs2709374; rs2709376; rs2709396; rs6785; rs7569963

# Macromolecular_Interacting_Partner_12_General_References:
2142528; 2196176; 1966745; 2974179; 1831258; 8381074; 7608156

# Macromolecular_Interacting_Partner_12_References:
12603604; 12670506; 15647252; 16165221

# Macromolecular_Interacting_Partner_13_ID:
7623

# Macromolecular_Interacting_Partner_13_Name:
Insulin-like growth factor-binding protein 3 precursor

# Macromolecular_Interacting_Partner_13_Synonyms:
IGFBP-3; IBP- 3; IGF-binding protein 3

# Macromolecular_Interacting_Partner_13_Gene_Name:
IGFBP3

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Insulinlike growth factorbinding protein 3 precursor
MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAE
LVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAV
SRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHA
KDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNC
DKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
291

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
31674

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
8.78

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  growth factor binding
Function:  insulin-like growth factor binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of growth
Process:  regulation of cell growth
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF00219:IGFBP;
PF00086:Thyroglobulin_1

# Macromolecular_Interacting_Partner_13_Signals:
1-27

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
183116

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
IBP3_HUMAN (P17936)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
IGFBP3

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
IGFBP3

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:5472

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>876 bp
ATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGCTGGTGCTGCTCCGC
GGGCCGCCGGTGGCGCGGGCTGGCGCGAGCTCGGGGGGCTTGGGTCCCGTGGTGCGCTGC
GAGCCGTGCGACGCGCGTGCACTGGCCCAGTGCGCGCCTCCGCCCGCCGTGTGCGCGGAG
CTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGAGCGAGGGCCAGCCG
TGCGGCATCTACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAG
GCGCGACCGCTGCAGGCGCTGCTGGACGGCCGCGGGCTCTGCGTCAACGCTAGTGCCGTC
AGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGAAATGCTAGTGAGTCG
GAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTG
TCTGATCCCAAGTTCCACCCCCTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCT
AAAGACAGCCAGCGCTACAAAGTTGACTACGAGTCTCAGAGCACAGATACCCAGAACTTC
TCCTCCGAGTCCAAGCGGGAGACAGAATATGGTCCCTGCCGTAGAGAAATGGAAGACACA
CTGAATCACCTGAAGTTCCTCAATGTGCTGAGTCCCAGGGGTGTACACATTCCCAACTGT
GACAAGAAGGGATTTTATAAGAAAAAGCAGTGTCGCCCTTCCAAAGGCAGGAAGCGGGGC
TTCTGCTGGTGTGTGGATAAGTATGGGCAGCCTCTCCCAGGCTACACCACCAAGGGGAAG
GAGGACGTGCACTGCTACAGCATGCAGAGCAAGTAG

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
M31159

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_13_Locus:
7p13-p12

# Macromolecular_Interacting_Partner_13_SNPs:
rs9282734; rs2854746; rs6950868; rs6670; rs2453840; rs2453839; rs34505796; rs35496550; rs35751739; rs34460927; rs34835646; rs3110697; rs6413441; rs6950802; rs2854747; rs6953668; rs33979592; rs2471551; rs12540724; rs3793345; rs2453837; rs35890775; rs34508316; rs34678704; rs10255707; rs34091405; rs17847673; rs1800906; rs35052563; rs34876509; rs34463602; rs2854750; rs35440925; rs34672517; rs9282735; rs10282088; rs11765572; rs10252403; rs2132570; rs13223993; rs10238613; rs2132572; rs2132571; rs13241830; rs35709394; rs35258778; rs34087654; rs34122177; rs34480712; rs34077804; rs3763500; rs2854744; rs35712717; rs17847676; rs34257987; rs34239916; rs34663167; rs35925180; rs2471549; rs34735423; rs11537920; rs11537915; rs9911; rs11537916; rs11537919; rs1050566; rs34735308; rs11537917; rs35704214; rs34930524; rs35689043; rs2515697; rs2854749; rs34515169; rs34833729; rs17847674; rs2645039; rs34988007; rs3110696; rs35683959; rs5883949; rs34331516; rs34014638; rs2645038; rs34898986; rs35350851; rs2645037; rs13230567; rs35872082; rs34720178; rs2854751; rs34424795; rs2854748; rs35855621; rs35610649; rs11292609; rs34881353; rs34006338; rs4302754; rs34533777; rs34351332; rs35017224; rs2854745; rs34097876; rs34058026; rs34939676; rs35533791; rs35919935; rs2645036; rs35300175; rs11773396; rs10230447; rs12671457; rs12671484; rs12702181; rs2088300; rs2088301; rs2270628; rs2453836; rs2515696; rs885555; rs903889; rs924140

# Macromolecular_Interacting_Partner_13_General_References:
2464130; 1695633; 7508771; 12853948; 1697583; 14561895

# Macromolecular_Interacting_Partner_13_References:
12663497; 16456404

# Macromolecular_Interacting_Partner_14_ID:
7628

# Macromolecular_Interacting_Partner_14_Name:
Nuclear factor NF-kappa-B p105 subunit

# Macromolecular_Interacting_Partner_14_Synonyms:
DNA-binding factor KBF1; EBP- 1[Contains: Nuclear factor NF-kappa-B p50 subunit]

# Macromolecular_Interacting_Partner_14_Gene_Name:
NFKB1

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>Nuclear factor NFkappaB p105 subunit
MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV
CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED
GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA
EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY
DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF
SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ
RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH
PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE
VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD
ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED
LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM
SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT
TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT
SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG
LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ
AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ
EGPLEGKI

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
968

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
105357

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
5.05

# Macromolecular_Interacting_Partner_14_GO_Classification:
>>>
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
Function:  binding
Function:  protein binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_14_General_Function:
Not Available

# Macromolecular_Interacting_Partner_14_Specific_Function:
Appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur posttranslationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. Plays a role in the regulation of apoptosis

# Macromolecular_Interacting_Partner_14_Pathway:
Not Available

# Macromolecular_Interacting_Partner_14_Reaction:
Not Available

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF00023:Ank;
PF00531:Death;
PF00554:RHD;
PF01833:TIG

# Macromolecular_Interacting_Partner_14_Signals:
None

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
189180

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
NFKB1_HUMAN (P19838)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
NFKB1

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
NFKB1

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:7794

# Macromolecular_Interacting_Partner_14_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B)

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>2910 bp
ATGGCAGAAGATGATCCATATTTGGGAAGGCCTGAACAAATGTTTCATTTGGATCCTTCT
TTGACTCATACAATATTTAATCCAGAAGTATTTCAACCACAGATGGCACTGCCAACAGCA
GATGGCCCATACCTTCAAATATTAGAGCAACCTAAACAGAGAGGATTTCGTTTCCGTTAT
GTATGTGAAGGCCCATCCCATGGTGGACTACCTGGTGCCTCTAGTGAAAAGAACAAGAAG
TCTTACCCTCAGGTCAAAATCTGCAACTATGTGGGACCAGCAAAGGTTATTGTTCAGTTG
GTCACAAATGGAAAAAATATCCACCTGCATGCCCACAGCCTGGTGGGAAAACACTGTGAG
GATGGGATCTGCACTGTAACTGCTGGACCCAAGGACATGGTGGTCGGCTTCGCAAACCTG
GGTATACTTCATGTGACAAAGAAAAAAGTATTTGAAACACTGGAAGCACGAATGACAGAG
GCGTGTATAAGGGGCTATAATCCTGGACTCTTGGTGCACCCTGACCTTGCCTATTTGCAA
GCAGAAGGTGGAGGGGACCGGCAGCTGGGAGATCGGGAAAAAGAGCTAATCCGCCAAGCA
GCTCTGCAGCAGACCAAGGAGATGGACCTCAGCGTGGTGCGGCTCATGTTTACAGCTTTT
CTTCCGGATAGCACTGGCAGCTTCACAAGGCGCCTGGAACCCGTGGTATCAGACGCCATC
TATGACAGTAAAGCCCCCAATGCATCCAACTTGAAAATTGTAAGAATGGACAGGACAGCT
GGATGTGTGACTGGAGGGGAGGAAATTTATCTTCTTTGTGACAAAGTTCAGAAAGATGAC
ATCCAGATTCGATTTTATGAAGAGGAAGAAAATGGTGGAGTCTGGGAAGGATTTGGAGAT
TTTTCCCCCACAGATGTTCATAGACAATTTGCCATTGTCTTCAAAACTCCAAAGTATAAA
GATATTAATATTACAAAACCAGCCTCTGTGTTTGTCCAGCTTCGGAGGAAATCTGACTTG
GAAACTAGTGAACCAAAACCTTTCCTCTACTATCCTGAAATCAAAGATAAAGAAGAAGTG
CAGAGGAAACGTCAGAAGCTCATGCCCAATTTTTCGGATAGTTTCGGCGGTGGTAGTGGT
GCCGGAGCTGGAGGCGGAGGCATGTTTGGTAGTGGCGGTGGAGGAGGGGGCACTGGAAGT
ACAGGTCCAGGGTATAGCTTCCCACACTATGGATTTCCTACTTATGGTGGGATTACTTTC
CATCCTGGAACTACTAAATCTAATGCTGGGATGAAGCATGGAACCATGGACACTGAATCT
AAAAAGGACCCTGAAGGTTGTGACAAAAGTGATGACAAAAACACTGTAAACCTCTTTGGG
AAAGTTATTGAAACCACAGAGCAAGATCAGGAGCCCAGCGAGGCCACCGTTGGGAATGGT
GAGGTCACTCTAACGTATGCAACAGGAACAAAAGAAGAGAGTGCTGGAGTTCAGGATAAC
CTCTTTCTAGAGAAGGCTATGCAGCTTGCAAAGAGGCATGCCAATGCCCTTTTCGACTAC
GCGGTGACAGGAGACGTGAAGATGCTGCTGGCCGTCCAGCGCCATCTCACTGCTGTGCAG
GATGAGAATGGGGACAGTGTCTTACACTTAGCAATCATCCACCTTCATTCTCAACTTGTG
AGGGATCTACTAGAAGTCACATCTGGTTTGATTTCTGATGACATTATCAACATGAGAAAT
GATCTGTACCAGACGCCCTTGCACTTGGCAGTGATCACTAAGCAGGAAGATGTGGTGGAG
GATTTGCTGAGGGCTGGGGCCGACCTGAGCCTTCTGGACCGCTTGGGTAACTCTGTTTTG
CACCTAGCTGCCAAAGAAGGACATGATAAAGTTCTCAGTATCTTACTCAAGCACAAAAAG
GCAGCACTACTTCTTGACCACCCCAACGGGGACGGTCTGAATGCCATTCATCTAGCCATG
ATGAGCAATAGCCTGCCATGTTTGCTGCTGCTGGTGGCCGCTGGGGCTGACGTCAATGCT
CAGGAGCAGAAGTCCGGGCGCACAGCACTGCACCTGGCTGTGGAGCACGACAACATCTCA
TTGGCAGGCTGCCTGCTCCTGGAGGGTGATGCCCATGTGGACAGTACTACCTACGATGGA
ACCACACCCCTGCATATAGCAGCTGGGAGAGGGTCCACCAGGCTGGCAGCTCTTCTCAAA
GCAGCAGGAGCAGATCCCCTGGTGGAGAACTTTGAGCCTCTCTATGACCTGGATGACTCT
TGGGAAAATGCAGGAGAGGATGAAGGAGTTGTGCCTGGAACCACGCCTCTAGATATGGCC
ACCAGCTGGCAGGTATTTGACATATTAAATGGGAAACCATATGAGCCAGAGTTTACATCT
GATGATTTACTAGCACAAGGAGACATGAAACAGCTGGCTGAAGATGTGAAGCTGCAGCTG
TATAAGTTACTAGAAATTCCTGATCCAGACAAAAACTGGGCTACTCTGGCGCAGAAATTA
GGTCTGGGGATACTTAATAATGCCTTCCGGCTGAGTCCTGCTCCTTCCAAAACACTTATG
GACAACTATGAGGTCTCTGGGGGTACAGTCAGAGAGCTGGTGGAGGCCCTGAGACAAATG
GGCTACACCGAAGCAATTGAAGTGATCCAGGCAGCCTCCAGCCCAGTGAAGACCACCTCT
CAGGCCCACTCGCTGCCTCTCTCGCCTGCCTCCACAAGGCAGCAAATAGACGAGCTCCGA
GACAGTGACAGTGTCTGCGACACGGGCGTGGAGACATCCTTCCGCAAACTCAGCTTTACC
GAGTCTCTGACCAGTGGTGCCTCACTGCTAACTCTCAACAAAATGCCCCATGATTATGGG
CAGGAAGGACCTCTAGAAGGCAAAATTTAG

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
M55643

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_14_Locus:
4q24

# Macromolecular_Interacting_Partner_14_SNPs:
rs4648099; rs4648072; rs4648085; rs1609993; rs4648109; rs4648094; rs4648093; rs1599961; rs1585213; rs1585214; rs1585215; rs230537; rs1598857; rs3774932; rs230536; rs4647980; rs4647968; rs3774938; rs1598856; rs3774934; rs3774937; rs4647972; rs3774933; rs3774936; rs4647981; rs17032720; rs17032705; rs4648144; rs4647978; rs4647970; rs2168803; rs35630491; rs6841533; rs4647965; rs34802427; rs11934404; rs4235404; rs1120986; rs4648143; rs10013613; rs41275743; rs35566216; rs4647983; rs4647975; rs4647966; rs17032740; rs1801; rs230544; rs170731; rs230494; rs93059; rs118882; rs1609798; rs230505; rs230491; rs230547; rs1020760; rs230504; rs230498; rs230521; rs230492; rs230526; rs230510; rs1598859; rs4648141; rs230522; rs909332; rs4648058; rs230496; rs230535; rs230527; rs1005819; rs230541; rs230512; rs4235405; rs909331; rs3774960; rs4648135; rs4648050; rs4699031; rs230511; rs3821958; rs230525; rs3774967; rs230495; rs11722146; rs1598861; rs230534; rs3774963; rs230520; rs3774956; rs230493; rs230529; rs230517; rs4699030; rs230507; rs3755867; rs3774959; rs230499; rs3774964; rs4648002; rs1287; rs230530; rs230497; rs4235406; rs1020759; rs4648052; rs7683854; rs4647992; rs230539; rs2293970; rs4648116; rs4648069; rs230519; rs3817685; rs4648011; rs13117745; rs230500; rs728440; rs4648131; rs4648095; rs4648127; rs230509; rs12509403; rs4648016; rs4648101; rs4648036; rs4648079; rs3774957; rs4648068; rs9790601; rs230538; rs4648059; rs4648102; rs230523; rs7684888; rs1610152; rs4648013; rs4648018; rs35628038; rs4648064; rs4648024; rs4648055; rs4648073; rs230528; rs4648049; rs230540; rs11723120; rs4648082; rs230542; rs4648062; rs4648108; rs4648006; rs4648107; rs4648137; rs3774968; rs1598858; rs230532; rs10489114; rs4648034; rs4648104; rs4648045; rs4648132; rs7340881; rs4648090; rs3083182; rs7667496; rs4648133; rs4648051; rs4648110; rs12509517; rs3774965; rs17032779; rs4648022; rs4648056; rs4648004; rs4648057; rs230531; rs230533; rs4648125; rs4648142; rs230518; rs17032781; rs4648015; rs4648134; rs4648130; rs34670343; rs4648037; rs4648128; rs4648091; rs4648043; rs17032850; rs4698858; rs7679591; rs4648123; rs4647997; rs17032920; rs4648008; rs3774966; rs4648009; rs230506; rs4648047; rs17032763; rs230516; rs4648038; rs4648060; rs4648113; rs4648117; rs4647991; rs11097789; rs35226141; rs4648136; rs4648106; rs4648063; rs4648122; rs4648029; rs230543; rs4648044; rs7654805; rs4648032; rs4648087; rs12509950; rs41477752; rs230513; rs36205989; rs4648040; rs4648126; rs4647987; rs34263415; rs725200; rs4648103; rs4647995; rs4648121; rs12641009; rs4648080; rs4648046; rs17032830; rs10023807; rs4648023; rs4648083; rs35121130; rs230514; rs230502; rs35857972; rs4648075; rs35822193; rs4648010; rs4648035; rs4648138; rs4648115; rs9996972; rs4648088; rs17032815; rs4648092; rs4648098; rs230503; rs4648084; rs4648026; rs17032771; rs230501; rs230515; rs6819573; rs35750259; rs4648111; rs4648096; rs4648129; rs4648053; rs11940017; rs28362491; rs16996774; rs11944443; rs4648086; rs4648065; rs4648118; rs41341444; rs11556612; rs4648003; rs41452949; rs1804009; rs4648119; rs4648039; rs3938376; rs2272676; rs13132317; rs34257045; rs11303983; rs35129546; rs4647969; rs4648145; rs4647974; rs35726481; rs3774935; rs34381316; rs28673338; rs4623003; rs4647967; rs4380526; rs4299585; rs4647973; rs34401471; rs35477220; rs4647977; rs13131592; rs2926005; rs35136542; rs6834596; rs13137392; rs34333104; rs961296; rs2103487; rs28677850; rs13104462; rs35014169; rs34022549; rs4647976; rs11556613; rs13147479; rs4647979; rs4647971; rs4648146; rs28520385; rs28484580; rs13132517; rs4647982; rs34126565; rs11728039; rs17234923; rs13132318; rs34926856; rs4648019; rs34021443; rs7440719; rs36217876; rs33911444; rs7682845; rs11397781; rs34233927; rs33948657; rs35606145; rs11368940; rs35791621; rs4648112; rs4648021; rs4647984; rs35444371; rs41452347; rs41469748; rs7679842; rs230524; rs34439575; rs6836486; rs10031217; rs4538482; rs4648078; rs34308797; rs4648054; rs4648097; rs4648139; rs1902849; rs4648031; rs10024951; rs28595328; rs7692606; rs11451855; rs41487649; rs647424; rs28406704; rs4648074; rs35886550; rs3774944; rs3830689; rs4648020; rs4648025; rs4648081; rs41275741; rs35031468; rs34771751; rs34933613; rs11320580; rs13149243; rs230508; rs11723768; rs34299444; rs35449997; rs35215784; rs4647999; rs35715251; rs34384275; rs4647998; rs41430146; rs41520150; rs28557116; rs4648012; rs13124438; rs4648077; rs41341146; rs34651181; rs4698859; rs3796408; rs4648048; rs4648033; rs34879511; rs4648007; rs9942301; rs28610412; rs11452345; rs6833549; rs3774951; rs34029484; rs3836563; rs4648140; rs34646774; rs28450894; rs35186646; rs34757231; rs28485089; rs4647985; rs35340745; rs34837589; rs4648076; rs4648028; rs4648089; rs34134600; rs36017625; rs3836562; rs35795162; rs35153016; rs11724677; rs4647994; rs4648030; rs35906490; rs35429536; rs4648017; rs4648114; rs4648071; rs35323892; rs34467687; rs4648041; rs10428399; rs10013190; rs35022229; rs34779942; rs4647989; rs12645604; rs7687966; rs4648014; rs4647988; rs35342982; rs3836564; rs11296045; rs35504484; rs11336046; rs34028525; rs35698833; rs11931621; rs12510977; rs7693670; rs34092684; rs35680095; rs4648067; rs647417; rs6843970; rs230546; rs35803083; rs28491436; rs4648061; rs4647986; rs4648027; rs4648120; rs4647996; rs33930729; rs4647990; rs34074793; rs9790373; rs3796409; rs34122180; rs35185023; rs4648042; rs4648070; rs3836561; rs2125212; rs4648005; rs4647993; rs36051664; rs34587686; rs4648124; rs3774961; rs28440950; rs33964959; rs3834210; rs4648105; rs4648066; rs4648001; rs35157203; rs10711129; rs11449359; rs28566809; rs35037058; rs10585671; rs6834974; rs13129088; rs4648000; rs4648100; rs28591630; rs34726463; rs11726195; rs36226652; rs11940065; rs4648147; rs35897145; rs34425291; rs10647550; rs6819775; rs35040256; rs10489113; rs11733293; rs12505960; rs12644738; rs12648696; rs17032985; rs17032989; rs17032996; rs17033015; rs4698860; rs4698861; rs4698862; rs4698863; rs747559; rs7674640; rs980455; rs997476

# Macromolecular_Interacting_Partner_14_General_References:
2203531; 2234062; 1992489; 8825636; 8087845; 8628291; 9529257; 10469655; 9950430; 10970863; 11094166; 11468175; 11297557; 12393603; 7830764; 9865693

# Macromolecular_Interacting_Partner_14_References:
12917341; 15145607; 15950952

# Macromolecular_Interacting_Partner_15_ID:
6559

# Macromolecular_Interacting_Partner_15_Name:
Mitogen-activated protein kinase 3

# Macromolecular_Interacting_Partner_15_Synonyms:
Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAPK 1; p44-ERK1; ERT2; p44-MAPK; Microtubule- associated protein 2 kinase

# Macromolecular_Interacting_Partner_15_Gene_Name:
MAPK3

# Macromolecular_Interacting_Partner_15_Protein_Sequence:
>Mitogenactivated protein kinase 3
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP

# Macromolecular_Interacting_Partner_15_Number_of_Residues:
379

# Macromolecular_Interacting_Partner_15_Molecular_Weight:
43136

# Macromolecular_Interacting_Partner_15_Theoretical_pI:
6.74

# Macromolecular_Interacting_Partner_15_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_15_General_Function:
Not Available

# Macromolecular_Interacting_Partner_15_Specific_Function:
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1

# Macromolecular_Interacting_Partner_15_Pathway:
Not Available

# Macromolecular_Interacting_Partner_15_Reaction:
Not Available

# Macromolecular_Interacting_Partner_15_Pfam_Domain_Function:
PF00069:Pkinase

# Macromolecular_Interacting_Partner_15_Signals:
None

# Macromolecular_Interacting_Partner_15_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_15_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_15_EC_Link:
EC 2.7.11.24

# Macromolecular_Interacting_Partner_15_GenBank_ID_Protein:
31221

# Macromolecular_Interacting_Partner_15_SwissProt_ID:
MK03_HUMAN (P27361)

# Macromolecular_Interacting_Partner_15_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_15_Genecard_id:
MAPK3

# Macromolecular_Interacting_Partner_15_Geneatlas_id:
MAPK3

# Macromolecular_Interacting_Partner_15_hgnc_id:
HGNC:6877

# Macromolecular_Interacting_Partner_15_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_15_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_15_Gene_Sequence:
>1140 bp
ATGGCGGCGGCGGCGGCTCAGGGGGGCGGGGGCGGGGAGCCCCGTAGAACCGAGGGGGTC
GGCCCGGGGGTCCCGGGGGAGGTGGAGATGGTGAAGGGGCAGCCGTTCGACGTGGGCCCG
CGCTACACGCAGTTGCAGTACATCGGCGAGGGCGCGTACGGCATGGTCAGCTCGGCCTAT
GACCACGTGCGCAAGACTCGCGTGGCCATCAAGAAGATCAGCCCCTTCGAACATCAGACC
TACTGCCAGCGCACGCTCCGGGAGATCCAGATCCTGCTGCGCTTCCGCCATGAGAATGTC
ATCGGCATCCGAGACATTCTGCGGGCGTCCACCCTGGAAGCCATGAGAGATGTCTACATT
GTGCAGGACCTGATGGAGACTGACCTGTACAAGTTGCTGAAAAGCCAGCAGCTGAGCAAT
GACCATATCTGCTACTTCCTCTACCAGATCCTGCGGGGCCTCAAGTACATCCACTCCGCC
AACGTGCTCCACCGAGATCTAAAGCCCTCCAACCTGCTCAGCAACACCACCTGCGACCTT
AAGATTTGTGATTTCGGCCTGGCCCGGATTGCCGATCCTGAGCATGACCACACCGGCTTC
CTGACGGAGTATGTGGCTACGCGCTGGTACCGGGCCCCAGAGATCATGCTGAACTCCAAG
GGCTATACCAAGTCCATCGACATCTGGTCTGTGGGCTGCATTCTGGCTGAGATGCTCTCT
AACCGGCCCATCTTCCCTGGCAAGCACTACCTGGATCAGCTCAACCACATTCTGGGCATC
CTGGGCTCCCCATCCCAGGAGGACCTGAATTGTATCATCAACATGAAGGCCCGAAACTAC
CTACAGTCTCTGCCCTCCAAGACCAAGGTGGCTTGGGCCAAGCTTTTCCCCAAGTCAGAC
TCCAAAGCCCTTGACCTGCTGGACCGGATGTTAACCTTTAACCCCAATAAACGGATCACA
GTGGAGGAAGCGCTGGCTCACCCCTACCTGGAGCAGTACTATGACCCGACGGATGAGCCA
GTGGCCGAGGAGCCCTTCACCTTCGCCATGGAGCTGGATGACCTACCTAAGGAGCGGCTG
AAGGAGCTCATCTTCCAGGAGACAGCACGCTTCCAGCCCGGAGTGCTGGAGGCCCCCTAG


# Macromolecular_Interacting_Partner_15_GenBank_ID_Gene:
X60188

# Macromolecular_Interacting_Partner_15_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_15_Locus:
16p11.2

# Macromolecular_Interacting_Partner_15_SNPs:
rs1143695; rs11865086; rs11864737; rs9921806; rs12922100; rs11863765; rs9930013; rs11546680; rs41292376; rs41291696; rs41280862; rs35691465; rs41280866; rs41280860; rs41280864; rs35666305; rs11644927; rs7199920; rs12918285; rs36084237; rs34799400; rs34564246; rs9940575; rs9940581; rs28529403; rs1042404; rs1062543; rs12924137; rs12930241; rs13569; rs1561414; rs2005219; rs3751867; rs7542; rs7698; rs8061772

# Macromolecular_Interacting_Partner_15_General_References:
7687743; 1540184; 1319925; 8794306

# Macromolecular_Interacting_Partner_15_References:
12670506; 16854387

# Macromolecular_Interacting_Partner_16_ID:
7653

# Macromolecular_Interacting_Partner_16_Name:
Catenin beta-1

# Macromolecular_Interacting_Partner_16_Synonyms:
Beta-catenin

# Macromolecular_Interacting_Partner_16_Gene_Name:
CTNNB1

# Macromolecular_Interacting_Partner_16_Protein_Sequence:
>Catenin beta1
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTS
QVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPT
NVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSK
KEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL
VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC
LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEA
GGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA
AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM
AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLL
VRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFV
QLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF
RMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFH
SGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTD
L

# Macromolecular_Interacting_Partner_16_Number_of_Residues:
781

# Macromolecular_Interacting_Partner_16_Molecular_Weight:
85498

# Macromolecular_Interacting_Partner_16_Theoretical_pI:
5.71

# Macromolecular_Interacting_Partner_16_GO_Classification:
>>>
Function:  binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_16_General_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Specific_Function:
Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway

# Macromolecular_Interacting_Partner_16_Pathway:
Not Available

# Macromolecular_Interacting_Partner_16_Reaction:
Not Available

# Macromolecular_Interacting_Partner_16_Pfam_Domain_Function:
PF00514:Arm;
PF02985:HEAT

# Macromolecular_Interacting_Partner_16_Signals:
None

# Macromolecular_Interacting_Partner_16_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_16_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_16_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_16_GenBank_ID_Protein:
860988

# Macromolecular_Interacting_Partner_16_SwissProt_ID:
CTNB1_HUMAN (P35222)

# Macromolecular_Interacting_Partner_16_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_16_Genecard_id:
CTNNB1

# Macromolecular_Interacting_Partner_16_Geneatlas_id:
CTNNB1

# Macromolecular_Interacting_Partner_16_hgnc_id:
HGNC:2514

# Macromolecular_Interacting_Partner_16_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_16_Subcellular_Location:
Cytoplasm. Nucleus. Note=Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 promotes nuclear translocation

# Macromolecular_Interacting_Partner_16_Gene_Sequence:
>2346 bp
ATGGCTACTCAAGCTGATTTGATGGAGTTGGACATGGCCATGGAACCAGACAGAAAAGCG
GCTGTTAGTCACTGGCAGCAACAGTCTTACCTGGACTCTGGAATCCATTCTGGTGCCACT
ACCACAGCTCCTTCTCTGAGTGGTAAAGGCAATCCTGAGGAAGAGGATGTGGATACCTCC
CAAGTCCTGTATGAGTGGGAACAGGGATTTTCTCAGTCCTTCACTCAAGAACAAGTAGCT
GATATTGATGGACAGTATGCAATGACTCGAGCTCAGAGGGTACGAGCTGCTATGTTCCCT
GAGACATTAGATGAGGGCATGCAGATCCCATCTACACAGTTTGATGCTGCTCATCCCACT
AATGTCCAGCGTTTGGCTGAACCATCACAGATGCTGAAACATGCAGTTGTAAACTTGATT
AACTATCAAGATGATGCAGAACTTGCCACACGTGCAATCCCTGAACTGACAAAACTGCTA
AATGACGAGGACCAGGTGGTGGTTAATAAGGCTGCAGTTATGGTCCATCAGCTTTCTAAA
AAGGAAGCTTCCAGACACGCTATCATGCGTTCTCCTCAGATGGTGTCTGCTATTGTACGT
ACCATGCAGAATACAAATGATGTAGAAACAGCTCGTTGTACCGCTGGGACCTTGCATAAC
CTTTCCCATCATCGTGAGGGCTTACTGGCCATCTTTAAGTCTGGAGGCATTCCTGCCCTG
GTGAAAATGCTTGGTTCACCAGTGGATTCTGTGTTGTTTTATGCCATTACAACTCTCCAC
AACCTTTTATTACATCAAGAAGGAGCTAAAATGGCAGTGCGTTTAGCTGGTGGGCTGCAG
AAAATGGTTGCCTTGCTCAACAAAACAAATGTTAAATTCTTGGCTATTACGACAGACTGC
CTTCAAATTTTAGCTTATGGCAACCAAGAAAGCAAGCTCATCATACTGGCTAGTGGTGGA
CCCCAAGCTTTAGTAAATATAATGAGGACCTATACTTACGAAAAACTACTGTGGACCACA
AGCAGAGTGCTGAAGGTGCTATCTGTCTGCTCTAGTAATAAGCCGGCTATTGTAGAAGCT
GGTGGAATGCAAGCTTTAGGACTTCACCTGACAGATCCAAGTCAACGTCTTGTTCAGAAC
TGTCTTTGGACTCTCAGGAATCTTTCAGATGCTGCAACTAAACAGGAAGGGATGGAAGGT
CTCCTTGGGACTCTTGTTCAGCTTCTGGGTTCAGATGATATAAATGTGGTCACCTGTGCA
GCTGGAATTCTTTCTAACCTCACTTGCAATAATTATAAGAACAAGATGATGGTCTGCCAA
GTGGGTGGTATAGAGGCTCTTGTGCGTACTGTCCTTCGGGCTGGTGACAGGGAAGACATC
ACTGAGCCTGCCATCTGTGCTCTTCGTCATCTGACCAGCCGACACCAAGAAGCAGAGATG
GCCCAGAATGCAGTTCGCCTTCACTATGGACTACCAGTTGTGGTTAAGCTCTTACACCCA
CCATCCCACTGGCCTCTGATAAAGGCTACTGTTGGATTGATTCGAAATCTTGCCCTTTGT
CCCGCAAATCATGCACCTTTGCGTGAGCAGGGTGCCATTCCACGACTAGTTCAGTTGCTT
GTTCGTGCACATCAGGATACCCAGCGCCGTACGTCCATGGGTGGGACACAGCAGCAATTT
GTGGAGGGGGTCCGCATGGAAGAAATAGTTGAAGGTTGTACCGGAGCCCTTCACATCCTA
GCTCGGGATGTTCACAACCGAATTGTTATCAGAGGACTAAATACCATTCCATTGTTTGTG
CAGCTGCTTTATTCTCCCATTGAAAACATCCAAAGAGTAGCTGCAGGGGTCCTCTGTGAA
CTTGCTCAGGACAAGGAAGCTGCAGAAGCTATTGAAGCTGAGGGAGCCACAGCTCCTCTG
ACAGAGTTACTTCACTCTAGGAATGAAGGTGTGGCGACATATGCAGCTGCTGTTTTGTTC
CGAATGTCTGAGGACAAGCCACAAGATTACAAGAAACGGCTTTCAGTTGAGCTGACCAGC
TCTCTCTTCAGAACAGAGCCAATGGCTTGGAATGAGACTGCTGATCTTGGACTTGATATT
GGTGCCCAGGGAGAACCCCTTGGATATCGCCAGGATGATCCTAGCTATCGTTCTTTTCAC
TCTGGTGGATATGGCCAGGATGCCTTGGGTATGGACCCCATGATGGAACATGAGATGGGT
GGCCACCACCCTGGTGCTGACTATCCAGTTGATGGGCTGCCAGATCTGGGGCATGCCCAG
GACCTCATGGATGGGCTGCCTCCAGGTGACAGCAATCAGCTGGCCTGGTTTGATACTGAC
CTGTAA

# Macromolecular_Interacting_Partner_16_GenBank_ID_Gene:
X87838

# Macromolecular_Interacting_Partner_16_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_16_Locus:
3p21

# Macromolecular_Interacting_Partner_16_SNPs:
rs4135384; rs3856746; rs3856747; rs2293303; rs1800663; rs4135379; rs3856748; rs9813198; rs2953; rs4533622; rs4016435; rs1798794; rs6776881; rs9867787; rs4973927; rs3915129; rs2371452; rs2140090; rs4135367; rs6792748; rs4135368; rs1798802; rs3834205; rs12492719; rs13075993; rs1722845; rs13072632; rs11564437; rs11129892; rs11920550; rs11564443; rs4135387; rs4135370; rs17199505; rs2371453; rs4973928; rs9872966; rs4135243; rs17054111; rs13076290; rs5743390; rs9820313; rs11708064; rs16339; rs11928435; rs11564440; rs4135388; rs4974075; rs5743383; rs11564436; rs4135366; rs4135374; rs2293302; rs3774371; rs1880481; rs3774369; rs5743391; rs11564474; rs11564447; rs11564477; rs2276826; rs4135385; rs4135381; rs11564473; rs5743395; rs11564445; rs11564446; rs11564450; rs3774370; rs11564475; rs11564465; rs11564478; rs11564456; rs11564459; rs11564460; rs11564464; rs13096546; rs11564461; rs11564463; rs11564458; rs11564467; rs11564452; rs11564448; rs11564454; rs11564468; rs11564453; rs17266083; rs11564457; rs3864004; rs11564431; rs11564486; rs11564430; rs28931588; rs28931589; rs35288908; rs4135386; rs5743392; rs13086686; rs34343353; rs35901713; rs35025041; rs5743389; rs34565533; rs4135244; rs35003074; rs11564439; rs34243856; rs11564442; rs4135365; rs35024316; rs3207381; rs28531867; rs1798792; rs34745712; rs11720097; rs11457773; rs11564438; rs5743386; rs11564435; rs4135373; rs11425223; rs34534133; rs1722851; rs13067975; rs34854135; rs11914865; rs3207382; rs5743385; rs11564434; rs7372252; rs4135372; rs1058355; rs10576683; rs34653633; rs11564479; rs35012062; rs11564441; rs4135371; rs35801414; rs4135389; rs5743384; rs4135369; rs4135375; rs5743387; rs34341265; rs34212725; rs35952434; rs35584784; rs1057513; rs35164905; rs13067968; rs34283755; rs35313837; rs17050830; rs4135376; rs35166040; rs11720409; rs35334729; rs4135378; rs3836494; rs11377041; rs1628844; rs11564470; rs11564451; rs35461809; rs2691680; rs10574857; rs11564449; rs35570424; rs11564476; rs35907471; rs11564455; rs34525870; rs3038134; rs11564472; rs11564469; rs11564462; rs4135380; rs5743393; rs11564444; rs11423812; rs4135377; rs5743396; rs11564466; rs11564471; rs4135382; rs7629538; rs33960177; rs36114955; rs5743394; rs35433269; rs2177140; rs34864544; rs35071363; rs3821833; rs11564428; rs3841963; rs11564487; rs11564483; rs11564488; rs9848755; rs11564433; rs11564484; rs11564429; rs11564432; rs11564485; rs35523547; rs11129895; rs11564490; rs11564491; rs11564492; rs11708951; rs11711946; rs11713042; rs11716602; rs12488691; rs12492279; rs13317032; rs2228683; rs2272216; rs2293304; rs2293305; rs2371485; rs2653480; rs4974074; rs6769117; rs6803275; rs7634002; rs9311265; rs9824212; rs9859392; rs9870255; rs9872276; rs9872571; rs9883073; rs9883839

# Macromolecular_Interacting_Partner_16_General_References:
7806582; 12019147; 10187801; 10966653; 11751639; 11279024; 11590244; 11389839; 12051714; 12297051; 12027456; 11834740; 12077367; 12830000; 10679188; 11136974; 11713475; 11713476; 12408824

# Macromolecular_Interacting_Partner_16_References:
15930180; 16717102

# Macromolecular_Interacting_Partner_17_ID:
6214

# Macromolecular_Interacting_Partner_17_Name:
Nitric oxide synthase, inducible

# Macromolecular_Interacting_Partner_17_Synonyms:
NOS type II; Inducible NO synthase; Inducible NOS; iNOS; Hepatocyte NOS; HEP- NOS

# Macromolecular_Interacting_Partner_17_Gene_Name:
NOS2A

# Macromolecular_Interacting_Partner_17_Protein_Sequence:
>Nitric oxide synthase, inducible
MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPL
VETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIM
TPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ
LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNI
RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG
RFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVG
GLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINI
AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEM
LNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVT
ILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPG
NGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGD
ELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDL
SKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQ
PALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQ
LLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQL
PILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCF
VRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPD
EDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLY
VCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDR
VAVQPSSLEMSAL

# Macromolecular_Interacting_Partner_17_Number_of_Residues:
1153

# Macromolecular_Interacting_Partner_17_Molecular_Weight:
131119

# Macromolecular_Interacting_Partner_17_Theoretical_pI:
8.01

# Macromolecular_Interacting_Partner_17_GO_Classification:
>>>
Function:  cofactor binding
Function:  coenzyme binding
Function:  NADP binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  FAD binding
Function:  tetrapyrrole binding
Function:  heme binding
Function:  protein binding
Function:  calmodulin binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  monooxygenase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen
Function:  nitric-oxide synthase activity
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
Function:  transporter activity
Function:  electron transporter activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  biosynthesis
Process:  nitric oxide biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_17_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_17_Specific_Function:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions

# Macromolecular_Interacting_Partner_17_Pathway:
map00330  Arginine and proline metabolism

# Macromolecular_Interacting_Partner_17_Reaction:
L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+

# Macromolecular_Interacting_Partner_17_Pfam_Domain_Function:
PF00667:FAD_binding_1;
PF00258:Flavodoxin_1;
PF00175:NAD_binding_1;
PF02898:NO_synthase

# Macromolecular_Interacting_Partner_17_Signals:
None

# Macromolecular_Interacting_Partner_17_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_17_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_17_EC_Link:
EC 1.14.13.39

# Macromolecular_Interacting_Partner_17_GenBank_ID_Protein:
292242

# Macromolecular_Interacting_Partner_17_SwissProt_ID:
NOS2A_HUMAN (P35228)

# Macromolecular_Interacting_Partner_17_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_17_Genecard_id:
NOS2A

# Macromolecular_Interacting_Partner_17_Geneatlas_id:
NOS2A

# Macromolecular_Interacting_Partner_17_hgnc_id:
HGNC:7873

# Macromolecular_Interacting_Partner_17_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_17_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_17_Gene_Sequence:
>3462 bp
ATGGCCTGTCCTTGGAAATTTCTGTTCAAGACCAAATTCCACCAGTATGCAATGAATGGG
GAAAAAGACATCAACAACAATGTGGAGAAAGCCCCCTGTGCCACCTCCAGTCCAGTGACA
CAGGATGACCTTCAGTATCACAACCTCAGCAAGCAGCAGAATGAGTCCCCGCAGCCCCTC
GTGGAGACGGGAAAGAAGTCTCCAGAATCTCTGGTCAAGCTGGATGCAACCCCATTGTCC
TCCCCACGGCATGTGAGGATCAAAAACTGGGGCAGCGGGATGACTTTCCAAGACACACTT
CACCATAAGGCCAAAGGGATTTTAACTTGCAGGTCCAAATCTTGCCTGGGGTCCATTATG
ACTCCCAAAAGTTTGACCAGAGGACCCAGGGACAAGCCTACCCCTCCAGATGAGCTTCTA
CCTCAAGCTATCGAATTTGTCAACCAATATTACGGCTCCTTCAAAGAGGCAAAAATAGAG
GAACATCTGGCCAGGGTGGAAGCGGTAACAAAGGAGATAGAAACAACAGGAACCTACCAA
CTGACGGGAGATGAGCTCATCTTCGCCACCAAGCAGGCCTGGCGCAATGCCCCACGCTGC
ATTGGGAGGATCCAGTGGTCCAACCTGCAGGTCTTCGATGCCCGCAGCTGTTCCACTGCC
CGGGAAATGTTTGAACACATCTGCAGACACGTGCGTTACTCCACCAACAATGGCAACATC
AGGTCGGCCATCACCGTGTTCCCCCAGCGGAGTGATGGCAAGCACGACTTCCGGGTGTGG
AATGCTCAGCTCATCCGCTATGCTGGCTACCAGATGCCAGATGGCAGCATCAGAGGGGAC
CCTGCCAACGTGGAATTCACTCAGCTGTGCATCGACCTGGGCTGGAAGCCCAAGTACGGC
CGCTTCGATGTGGTCCCCCTGGTCCTGCAGGCCAATGGCCGTGACCCTGAGCTCTTCGAA
ATCCCACCTGACCTTGTGCTTGAGGTGGCCATGGAACATCCCAAATACGAGTGGTTTCGG
GAACTGGAGCTAAAGTGGTACGCCCTGCCTGCAGTGGCCAACATGCTGCTTGAGGTGGGC
GGCCTGGAGTTCCCAGGGTGCCCCTTCAATGGCTGGTACATGGGCACAGAGATCGGAGTC
CGGGACTTCTGTGACGTCCAGCGCTACAACATCCTGGAGGAAGTGGGCAGGAGAATGGGC
CTGGAAACGCACAAGCTGGCCTCGCTCTGGAAAGACCAGGCTGTCGTTGAGATCAACATT
GCTGTGATCCATAGTTTTCAGAAGCAGAATGTGACCATCATGGACCACCACTCGGCTGCA
GAATCCTTCATGAAGTACATGCAGAATGAATACCGGTCCCGTGGGGGCTGCCCGGCAGAC
TGGATTTGGCTGGTCCCTCCCATGTCTGGGAGCATCACCCCCGTGTTTCACCAGGAGATG
CTGAACTACGTCCTGTCCCCTTTCTACTACTATCAGGTAGAGGCCTGGAAAACCCATGTC
TGGCAGGACGAGAAGCGGAGACCCAAGAGAAGAGAGATTCCATTGAAAGTCTTGGTCAAA
GCTGTGCTCTTTGCCTGTATGCTGATGCGCAAGACAATGGCGTCCCGAGTCAGAGTCACC
ATCCTCTTTGCGACAGAGACAGGAAAATCAGAGGCGCTGGCCTGGGACCTGGGGGCCTTA
TTCAGCTGTGCCTTCAACCCCAAGGTTGTCTGCATGGATAAGTACAGGCTGAGCTGCCTG
GAGGAGGAACGGCTGCTGTTGGTGGTGACCAGTACGTTTGGCAATGGAGACTGCCCTGGC
AATGGAGAGAAACTGAAGAAATCGCTCTTCATGCTGAAAGAGCTCAACAACAAATTCAGG
TACGCTGTGTTTGGCCTCGGCTCCAGCATGTACCCTCGGTTCTGCGCCTTTGCTCATGAC
ATTGATCAGAAGCTGTCCCACCTGGGGGCCTCTCAGCTCACCCCGATGGGAGAAGGGGAT
GAGCTCAGTGGGCAGGAGGACGCCTTCCGCAGCTGGGCCGTGCAAACCTTCAAGGCAGCC
TGTGAGACGTTTGATGTCCGAGGCAAACAGCACATTCAGATCCCCAAGCTCTACACCTCC
AATGTGACCTGGGACCCGCACCACTACAGGCTCGTGCAGGACTCACAGCCTTTGGACCTC
AGCAAAGCCCTCAGCAGCATGCATGCCAAGAACGTGTTCACCATGAGGCTCAAATCTCGG
CAGAATCTACAAAGTCCGACATCCAGCCGTGCCACCATCCTGGTGGAACTCTCCTGTGAG
GATGGCCAAGGCCTGAACTACCTGCCGGGGGAGCACCTTGGGGTTTGCCCAGGCAACCAG
CCGGCCCTGGTCCAAGGCATCCTGGAGCGAGTGGTGGATGGCCCCACACCCCACCAGACA
GTGCGCCTGGAGGACCTGGATGAGAGTGGCAGCTACTGGGTCAGTGACAAGAGGCTGCCC
CCCTGCTCACTCAGCCAGGCCCTCACCTACTCCCCGGACATCACCACACCCCCAACCCAG
CTGCTGCTCCAAAAGCTGGCCCAGGTGGCCACAGAAGAGCCTGAGAGACAGAGGCTGGAG
GCCCTGTGCCAGCCCTCAGAGTACAGCAAGTGGAAGTTCACCAACAGCCCCACATTCCTG
GAGGTGCTAGAGGAGTTCCCGTCCCTGCGGGTGTCTGCTGGCTTCCTGCTTTCCCAGCTC
CCCATTCTGAAGCCCAGGTTCTACTCCATCAGCTCCTCCCGGGATCACACGCCCACGGAG
ATCCACCTGACTGTGGCCGTGGTCACCTACCACACCGGAGATGGCCAGGGTCCCCTGCAC
CACGGTGTCTGCAGCACATGGCTCAACAGCCTGAAGCCCCAAGACCCAGTGCCCTGCTTT
GTGCGGAATGCCAGCGCCTTCCACCTCCCCGAGGATCCCTCCCATCCTTGCATCCTCATC
GGGCCTGGCACAGGCATCGTGCCCTTCCGCAGTTTCTGGCAGCAACGGCTCCATGACTCC
CAGCACAAGGGAGTGCGGGGAGGCCGCATGACCTTGGTGTTTGGGTGCCGCCGCCCAGAT
GAGGACCACATCTACCAGGAGGAGATGCTGGAGATGGCCCAGAAGGGGGTGCTGCATGCG
GTGCACACAGCCTATTCCCGCCTGCCTGGCAAGCCCAAGGTCTATGTTCAGGACATCCTG
CGGCAGCAGCTGGCCAGCGAGGTGCTCCGTGTGCTCCACAAGGAGCCAGGCCACCTCTAT
GTTTGCGGGGATGTGCGCATGGCCCGGGACGTGGCCCACACCCTGAAGCAGCTGGTGGCT
GCCAAGCTGAAATTGAATGAGGAGCAGGTCGAGGACTATTTCTTTCAGCTCAAGAGCCAG
AAGCGCTATCACGAAGATATCTTCGGTGCTGTATTTCCTTACGAGGCGAAGAAGGACAGG
GTGGCGGTGCAGCCCAGCAGCCTGGAGATGTCAGCGCTCTGA

# Macromolecular_Interacting_Partner_17_GenBank_ID_Gene:
L09210

# Macromolecular_Interacting_Partner_17_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_17_Locus:
17q11.2-q12

# Macromolecular_Interacting_Partner_17_SNPs:
rs3730017; rs2297518; rs3729662; rs3730014; rs1137933; rs28999412; rs16966563; rs28730832; rs1060826; rs1060822; rs10459953; rs3730013; rs6505483; rs28998796; rs15782; rs28998799; rs3201742; rs28998798; rs2872753; rs944725; rs2314809; rs4795067; rs2297512; rs944724; rs9895831; rs3794763; rs3729966; rs4239250; rs8068149; rs3729508; rs4796052; rs944722; rs2297520; rs9904158; rs9797244; rs7208775; rs11080344; rs3729718; rs3794764; rs28450000; rs8080418; rs2297515; rs2297514; rs3730228; rs2297517; rs8065448; rs3794767; rs3794759; rs8070472; rs12452167; rs944723; rs17722851; rs3794756; rs4796040; rs2297511; rs3794765; rs4796034; rs8072199; rs10853180; rs2297510; rs3729507; rs16966545; rs2297513; rs8073631; rs9895453; rs17718148; rs2274894; rs7217335; rs3729719; rs2072324; rs2314812; rs3729720; rs3729727; rs2297516; rs8065817; rs3794766; rs8067880; rs3730234; rs9282801; rs9282800; rs3729661; rs4796080; rs2248814; rs6505445; rs9906835; rs9906122; rs28942375; rs11653716; rs3730232; rs1113283; rs28944194; rs28999408; rs3794761; rs8067177; rs28999370; rs41353546; rs28944186; rs2314813; rs11871315; rs28998815; rs6505469; rs28999387; rs28662210; rs28944196; rs28998832; rs28942968; rs28999414; rs28944190; rs28998809; rs28999393; rs28942373; rs16949; rs28944178; rs28999401; rs28998802; rs28999394; rs28944211; rs7213691; rs28998818; rs28998804; rs28944206; rs28998821; rs28944208; rs28998812; rs28944197; rs28999391; rs28999385; rs28944181; rs28999374; rs28998828; rs28999413; rs28999398; rs28998814; rs11870951; rs11871150; rs28998808; rs28944177; rs28998817; rs28999400; rs28944213; rs11657646; rs28999409; rs28942372; rs28999380; rs28998826; rs9890954; rs28942370; rs2255929; rs4796038; rs28944180; rs28998831; rs28944198; rs28999405; rs28942368; rs28944169; rs28999384; rs28944182; rs28999377; rs28998807; rs28998805; rs28944205; rs28998822; rs28999399; rs28944195; rs1962380; rs28944209; rs28944192; rs28999375; rs28944193; rs2314810; rs28999383; rs28999390; rs28999410; rs2779248; rs7406657; rs12450521; rs2779249; rs8081248; rs8078340; rs28943568; rs28944221; rs1800482; rs28998792; rs28944230; rs28998790; rs28944231; rs28944218; rs28973255; rs28944222; rs28944229; rs28944224; rs9282799; rs11080321; rs28998795; rs28944227; rs4795055; rs4796029; rs28944232; rs28944220; rs2314808; rs3730230; rs28944201; rs3729717; rs28944173; rs28999379; rs34719207; rs28944168; rs1137949; rs1060828; rs7223110; rs28944200; rs28944214; rs35834812; rs7359686; rs28998800; rs12453234; rs28944216; rs7359651; rs28998797; rs28944215; rs28944217; rs34749068; rs3794757; rs16948; rs34293265; rs28999411; rs41337547; rs28999396; rs28944202; rs34641676; rs3730231; rs28999403; rs7502274; rs4796055; rs10557822; rs28999368; rs9895077; rs34975273; rs28942378; rs28999407; rs28999372; rs3751971; rs9282802; rs28944171; rs34931287; rs35370851; rs28998816; rs28942369; rs28998825; rs28944184; rs28944212; rs11363739; rs28999404; rs34972969; rs28944176; rs28999376; rs28999415; rs28942379; rs28998811; rs11363740; rs28998827; rs41449853; rs28942376; rs35659482; rs3730015; rs28944185; rs28944188; rs28944191; rs28944172; rs28944174; rs10569534; rs28944179; rs28722995; rs3838879; rs28999371; rs28999389; rs28999382; rs28942374; rs28999397; rs34658875; rs7222398; rs28944170; rs28999416; rs3838880; rs28944183; rs28998824; rs4796041; rs41323846; rs28999386; rs28999378; rs28999406; rs34992777; rs28998829; rs28998833; rs3794760; rs28999373; rs35214201; rs28998810; rs3833855; rs28998806; rs28944189; rs34069634; rs28998803; rs28999369; rs28998830; rs41513847; rs28998823; rs12950084; rs28944199; rs28944203; rs35561933; rs11428460; rs34388532; rs5819821; rs35660190; rs35051118; rs28998813; rs35395276; rs28999392; rs28942377; rs34237194; rs28998801; rs3730016; rs28999395; rs28942371; rs3794758; rs11655101; rs28944210; rs28998819; rs34147660; rs28944175; rs28944207; rs10657353; rs28730831; rs3838881; rs28999388; rs28999402; rs28999381; rs28999417; rs28944187; rs34921306; rs3730229; rs28998820; rs28944223; rs28998794; rs35009352; rs28944228; rs34709845; rs28943570; rs28944226; rs1799765; rs28998793; rs28944233; rs28998791; rs28943569; rs28944225; rs28944219; rs12720460; rs28943571; rs34517795; rs11080358; rs12150211; rs12709500; rs16966425; rs2531860; rs2531861; rs2531862; rs2531863; rs2734299; rs2779251; rs2779252; rs2779253; rs2779254; rs2779255; rs4795050; rs4796018; rs4796028; rs7208420; rs7215373; rs8073782

# Macromolecular_Interacting_Partner_17_General_References:
7682706; 7692964; 7504305; 7522054; 7528017; 7531687; 7544004; 9160867; 7532248; 7558036; 9721329; 12080081; 10409685; 10074942

# Macromolecular_Interacting_Partner_17_References:
15087030; 16091294

# Macromolecular_Interacting_Partner_18_ID:
6263

# Macromolecular_Interacting_Partner_18_Name:
Prostaglandin G/H synthase 2 precursor

# Macromolecular_Interacting_Partner_18_Synonyms:
Cyclooxygenase- 2; COX-2; Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; PHS II

# Macromolecular_Interacting_Partner_18_Gene_Name:
PTGS2

# Macromolecular_Interacting_Partner_18_Protein_Sequence:
>Prostaglandin G/H synthase 2 precursor
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPT
PNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNAD
YGYKSWEAFSNLSYYTRALPP
VPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQ
GSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGL
GHGVDLNHIYGETLARQRKLRLFKDGK
MKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGL
VPGLMMYATIWLREHN
RVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPE
LLFNK
QFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQ
IAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMS
AELEALYGDIDAVELY
PALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKP
STFGGEVGFQIINTASIQSLICNNVKG
CPFTSFSVPDPELIKTVTINASSSRSGLDDIN
PTVLLKERSTEL

# Macromolecular_Interacting_Partner_18_Number_of_Residues:
604

# Macromolecular_Interacting_Partner_18_Molecular_Weight:
68997

# Macromolecular_Interacting_Partner_18_Theoretical_pI:
7.41

# Macromolecular_Interacting_Partner_18_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_18_General_Function:
Not Available

# Macromolecular_Interacting_Partner_18_Specific_Function:
May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity

# Macromolecular_Interacting_Partner_18_Pathway:
map00590  Prostaglandin and leukotriene metabolism

# Macromolecular_Interacting_Partner_18_Reaction:
arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

# Macromolecular_Interacting_Partner_18_Pfam_Domain_Function:
PF03098:An_peroxidase;
PF00008:EGF

# Macromolecular_Interacting_Partner_18_Signals:
1-17

# Macromolecular_Interacting_Partner_18_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_18_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_18_EC_Link:
EC 1.14.99.1

# Macromolecular_Interacting_Partner_18_GenBank_ID_Protein:
291988

# Macromolecular_Interacting_Partner_18_SwissProt_ID:
PGH2_HUMAN (P35354)

# Macromolecular_Interacting_Partner_18_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_18_Genecard_id:
PTGS2

# Macromolecular_Interacting_Partner_18_Geneatlas_id:
PTGS2

# Macromolecular_Interacting_Partner_18_hgnc_id:
HGNC:9605

# Macromolecular_Interacting_Partner_18_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_18_Subcellular_Location:
Microsome; microsomal membrane; peripheral membrane protein

# Macromolecular_Interacting_Partner_18_Gene_Sequence:
>1815 bp

ATGCTCGCCCGCGCCCTGCTGCTGTGCGCGGTCCTGGCGCTCAGCCATACAGCAAATCC
TTGCTGTTCCC
ACCCATGTCAAAACCGAGGTGTATGTATGAGTGTGGGATTTGACCAGT
ATAAGTGCGATTGTACCCGGAC
AGGATTCTATGGAGAAAACTGCTCAACACCGGAATTT
TTGACAAGAATAAAATTATTTCTGAAACCCACT
CCAAACACAGTGCACTACATACTTAC
CCACTTCAAGGGATTTTGGAACGTTGTGAATAACATTCCCTTCC
TTCGAAATGCAATTA
TGAGTTATGTGTTGACATCCAGATCACATTTGATTGACAGTCCACCAACTTACAA
TGCT
GACTATGGCTACAAAAGCTGGGAAGCCTTCTCTAACCTCTCCTATTATACTAGAGCCCTT
CCTCCT
GTGCCTGATGATTGCCCGACTCCCTTGGGTGTCAAAGGTAAAAAGCAGCTTCC
TGATTCAAATGAGATTG
TGGAAAAATTGCTTCTAAGAAGAAAGTTCATCCCTGATCCCC
AGGGCTCAAACATGATGTTTGCATTCTT
TGCCCAGCACTTCACGCATCAGTTTTTCAAG
ACAGATCATAAGCGAGGGCCAGCTTTCACCAACGGGCTG
GGCCATGGGGTGGACTTAAA
TCATATTTACGGTGAAACTCTGGCTAGACAGCGTAAACTGCGCCTTTTCA
AGGATGGAA
AAATGAAATATCAGATAATTGATGGAGAGATGTATCCTCCCACAGTCAAAGATACTCAGG
C
AGAGATGATCTACCCTCCTCAAGTCCCTGAGCATCTACGGTTTGCTGTGGGGCAGGAG
GTCTTTGGTCTG
GTGCCTGGTCTGATGATGTATGCCACAATCTGGCTGCGGGAACACAA
CAGAGTATGCGATGTGCTTAAAC
AGGAGCATCCTGAATGGGGTGATGAGCAGTTGTTCC
AGACAAGCAGGCTAATACTGATAGGAGAGACTAT
TAAGATTGTGATTGAAGATTATGTG
CAACACTTGAGTGGCTATCACTTCAAACTGAAATTTGACCCAGAA
CTACTTTTCAACAA
ACAATTCCAGTACCAAAATCGTATTGCTGCTGAATTTAACACCCTCTATCACTGGC
ATC
CCCTTCTGCCTGACACCTTTCAAATTCATGACCAGAAATACAACTATCAACAGTTTATCT
ACAACAA
CTCTATATTGCTGGAACATGGAATTACCCAGTTTGTTGAATCATTCACCAGG
CAAATTGCTGGCAGGGTT
GCTGGTGGTAGGAATGTTCCACCCGCAGTACAGAAAGTATC
ACAGGCTTCCACTGACCAGAGCAGGCAGA
TGAAATACCAGTCTTTTAATGAGTACCGCA
AACGCTTTATGCTGAAGCCCTATGAATCATTTGAAGAACT
TACAGGAGAAAAGGAAATG
TCTGCAGAGTTGGAAGCACTCTATGGTGACATCGATGCTGTGGAGCTGTAT
CCTGCCCT
TCTGGTAGAAAAGCCTCGGCCAGATGCCATCTTTGGTGAAACCATGGTAGAAGTTGGAGC
AC
CATTCTCCTTGAAAGGACTTATGGGTAATGTTATATGTTCTCCTGCCTACTGGAAGC
CAAGCACTTTTGG
TGGAGAAGTGGGTTTTCAAATCATCAACACTGCCTCAATTCAGTCT
CTCATCTGCAATAACGTGAAGGGC
TGTCCCTTTACTTCATTCAGTGTTCCAGATCCAGA
GCTCATTAAAACAGTCACCATCAATGCAAGTTCTT
CCCGCTCCGGACTAGATGATATCA
ATCCCACAGTACTACTAAAAGAACGTTCGACTGAACTGTAG

# Macromolecular_Interacting_Partner_18_GenBank_ID_Gene:
L15326

# Macromolecular_Interacting_Partner_18_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_18_Locus:
1q25.2-q25.3

# Macromolecular_Interacting_Partner_18_SNPs:
rs3218622; rs5272; rs5273; rs3218625; rs5279; rs5277; rs5278; rs5274; rs3218623; rs20429; rs4648265; rs5276; rs5275; rs2206593; rs4648292; rs689469; rs5271; rs3835508; rs689467; rs689470; rs689468; rs4648257; rs4648303; rs1051897; rs4648300; rs4648290; rs1051896; rs4648297; rs4648302; rs4648296; rs20432; rs2066826; rs4648268; rs4648287; rs20427; rs4648283; rs4648274; rs4648273; rs4648278; rs20430; rs4648284; rs20428; rs4648272; rs11567821; rs4648276; rs4648282; rs4648261; rs2745557; rs2066824; rs4648285; rs4648267; rs2066823; rs4648263; rs16825748; rs3218626; rs4648277; rs11567827; rs11567834; rs4648280; rs20434; rs2066822; rs4648271; rs4648262; rs4648258; rs16825745; rs20433; rs20424; rs4648306; rs20419; rs4648307; rs20415; rs4648308; rs689466; rs689465; rs20418; rs5270; rs4648251; rs4648256; rs4648304; rs4648310; rs20417; rs4648250; rs3918304; rs4648311; rs689462; rs20423; rs20420; rs2734779; rs11567815; rs11567831; rs11567814; rs4648309; rs20416; rs4648305; rs4648254; rs20426; rs4648279; rs4648264; rs4648288; rs3218624; rs3179567; rs4648295; rs36233646; rs3134592; rs3134591; rs4648299; rs4648298; rs13306032; rs11384450; rs11567830; rs13306038; rs3134589; rs13306033; rs2853804; rs3134590; rs2853805; rs11567829; rs11567819; rs4648289; rs4648301; rs13306035; rs34888870; rs4648294; rs13306031; rs4648293; rs2853803; rs4987012; rs12759220; rs11567822; rs4648260; rs4648269; rs11567826; rs13306034; rs4648259; rs11567820; rs4648266; rs11567825; rs4648281; rs11567824; rs11567823; rs4648286; rs4648270; rs4322189; rs35440347; rs11567835; rs689463; rs4648253; rs2223626; rs11567832; rs689464; rs20421; rs4648252; rs2745558; rs34901173; rs4648255; rs11567833; rs20422; rs11567837; rs11567836; rs12027712; rs10649972; rs10911902; rs10911905; rs10911907; rs10911908; rs1119064; rs1119065; rs11583191; rs12042763; rs12064238; rs12124257; rs12749248; rs2143416; rs2143417; rs2179555; rs2383515; rs2734776; rs2734777; rs2745559; rs4422959; rs6684912

# Macromolecular_Interacting_Partner_18_General_References:
8473346; 1380156; 8181472; 7945196

# Macromolecular_Interacting_Partner_18_References:
12963019; 14596920; 14971826; 15063780

# Macromolecular_Interacting_Partner_19_ID:
7657

# Macromolecular_Interacting_Partner_19_Name:
Peroxisome proliferator-activated receptor gamma

# Macromolecular_Interacting_Partner_19_Synonyms:
PPAR-gamma

# Macromolecular_Interacting_Partner_19_Gene_Name:
PPARG

# Macromolecular_Interacting_Partner_19_Protein_Sequence:
>Peroxisome proliferatoractivated receptor gamma
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY

# Macromolecular_Interacting_Partner_19_Number_of_Residues:
505

# Macromolecular_Interacting_Partner_19_Molecular_Weight:
57621

# Macromolecular_Interacting_Partner_19_Theoretical_pI:
5.77

# Macromolecular_Interacting_Partner_19_GO_Classification:
>>>
Function:  steroid hormone receptor activity
Function:  transcription factor activity
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_19_General_Function:
Not Available

# Macromolecular_Interacting_Partner_19_Specific_Function:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis

# Macromolecular_Interacting_Partner_19_Pathway:
Not Available

# Macromolecular_Interacting_Partner_19_Reaction:
Not Available

# Macromolecular_Interacting_Partner_19_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_19_Signals:
None

# Macromolecular_Interacting_Partner_19_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_19_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_19_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_19_GenBank_ID_Protein:
1711117

# Macromolecular_Interacting_Partner_19_SwissProt_ID:
PPARG_HUMAN (P37231)

# Macromolecular_Interacting_Partner_19_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_19_Genecard_id:
PPARG

# Macromolecular_Interacting_Partner_19_Geneatlas_id:
PPARG

# Macromolecular_Interacting_Partner_19_hgnc_id:
HGNC:9236

# Macromolecular_Interacting_Partner_19_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_19_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_19_Gene_Sequence:
>1518 bp
ATGGGTGAAACTCTGGGAGATTCTCCTATTGACCCAGAAAGCGATTCCTTCACTGATACA
CTGTCTGCAAACATATCACAAGAAATGACCATGGTTGACACAGAGATGCCATTCTGGCCC
ACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCACTCCTTT
GATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGAC
ATTCCATTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATGACCTGAAACTTCAA
GAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAGAAGACT
CAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGT
GTCTGTGGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAG
GGTTTCTTCCGGAGAACAATCAGATTGAAGCTTATCTATGACAGATGTGATCTTAACTGT
CGGATCCACAAAAAAAGTAGAAATAAATGTCAGTACTGTCGGTTTCAGAAATGCCTTGCA
GTGGGGATGTCTCATAATGCCATCAGGTTTGGGCGGATGCCACAGGCCGAGAAGGAGAAG
CTGTTGGCGGAGATCTCCAGTGATATCGACCAGCTGAATCCAGAGTCCGCTGACCTCCGG
GCCCTGGCAAAACATTTGTATGACTCATACATAAAGTCCTTCCCGCTGACCAAAGCAAAG
GCGAGGGCGATCTTGACAGGAAAGACAACAGACAAATCACCATTCGTTATCTATGACATG
AATTCCTTAATGATGGGAGAAGATAAAATCAAGTTCAAACACATCACCCCCCTGCAGGAG
CAGAGCAAAGAGGTGGCCATCCGCATCTTTCAGGGCTGCCAGTTTCGCTCCGTGGAGGCT
GTGCAGGAGATCACAGAGTATGCCAAAAGCATTCCTGGTTTTGTAAATCTTGACTTGAAC
GACCAAGTAACTCTCCTCAAATATGGAGTCCACGAGATCATTTACACAATGCTGGCCTCC
TTGATGAATAAAGATGGGGTTCTCATATCCGAGGGCCAAGGCTTCATGACAAGGGAGTTT
CTAAAGAGCCTGCGAAAGCCTTTTGGTGACTTTATGGAGCCCAAGTTTGAGTTTGCTGTG
AAGTTCAATGCACTGGAATTAGATGACAGCGACTTGGCAATATTTATTGCTGTCATTATT
CTCAGTGGAGACCGCCCAGGTTTGCTGAATGTGAAGCCCATTGAAGACATTCAAGACAAC
CTGCTACAAGCCCTGGAGCTCCAGCTGAAGCTGAACCACCCTGAGTCCTCACAGCTGTTT
GCCAAGCTGCTCCAGAAAATGACAGACCTCAGACAGATTGTCACGGAACACGTGCAGCTA
CTGCAGGTGATCAAGAAGACGGAGACAGACATGAGTCTTCACCCGCTCCTGCAGGAGATC
TACAAGGACTTGTACTAG

# Macromolecular_Interacting_Partner_19_GenBank_ID_Gene:
U79012

# Macromolecular_Interacting_Partner_19_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_19_Locus:
3p25

# Macromolecular_Interacting_Partner_19_SNPs:
rs1801282; rs3856806; rs4135352; rs13306747; rs1805151; rs2921188; rs2881654; rs6776454; rs12496005; rs2197423; rs4135307; rs4135315; rs4135316; rs880663; rs9829551; rs11128598; rs12636454; rs4135304; rs4135255; rs4135322; rs12631389; rs6800910; rs4135311; rs12487012; rs4135321; rs4135305; rs1064323; rs6800748; rs12496505; rs2120825; rs4135301; rs10510412; rs2028759; rs4135323; rs6802898; rs12629240; rs7647481; rs13095716; rs4135313; rs4684101; rs6805419; rs4135302; rs7627605; rs6809631; rs9310401; rs4135245; rs9817428; rs1899951; rs2938397; rs4135259; rs4135308; rs10865710; rs11715073; rs4684848; rs4135320; rs3885307; rs6778740; rs12629293; rs4135246; rs12636461; rs13433696; rs1373641; rs9812662; rs12639162; rs4135306; rs12633551; rs12497191; rs9858822; rs12629751; rs4135253; rs7648033; rs1596667; rs11128597; rs13083375; rs13070963; rs2007629; rs12630210; rs4135254; rs11128601; rs4135258; rs10510410; rs4135310; rs4145574; rs4135317; rs7646510; rs7636145; rs17036342; rs6768587; rs7620165; rs2012444; rs6798974; rs4135256; rs3892175; rs13073869; rs1122648; rs6782178; rs4145573; rs10510411; rs4135319; rs4135318; rs2938398; rs2972167; rs964232; rs4135247; rs2028760; rs17036328; rs10510418; rs9883281; rs11128603; rs4135312; rs6442311; rs12493718; rs9851767; rs2921189; rs11128599; rs17817276; rs6785890; rs13061415; rs2938396; rs4135248; rs4135257; rs4135303; rs6442310; rs12485478; rs7638903; rs7617488; rs28763893; rs4135250; rs17793693; rs12490265; rs17036326; rs7646425; rs4135249; rs2972164; rs1373640; rs17036263; rs4135251; rs4135314; rs12631819; rs11710969; rs7638788; rs17036321; rs11128596; rs4135309; rs12639094; rs17036188; rs6795085; rs12629497; rs3112395; rs6808179; rs2920505; rs12631028; rs6795946; rs13064760; rs6809832; rs35206526; rs7649970; rs17036314; rs11128600; rs4684845; rs10865711; rs12631322; rs7615916; rs9882725; rs9849386; rs2067819; rs11716748; rs17817469; rs17029006; rs4684846; rs2881479; rs17036242; rs6788489; rs11719186; rs6792284; rs4073770; rs12634544; rs2972168; rs2921190; rs9842021; rs13306745; rs11715016; rs11128602; rs13076055; rs12496413; rs7610055; rs9823137; rs9883193; rs17435731; rs2346795; rs4362702; rs10510417; rs6768049; rs12330440; rs12495364; rs9814788; rs17029008; rs2067820; rs6766920; rs11709077; rs2960422; rs17425935; rs17036163; rs17036281; rs17036160; rs6801982; rs4518111; rs17050719; rs3112393; rs4684847; rs17036174; rs17036282; rs10212597; rs34359034; rs17036165; rs35080475; rs17036333; rs17793951; rs1984669; rs17036170; rs12486170; rs9876942; rs12635309; rs4315668; rs11718775; rs9870196; rs3963364; rs1373642; rs1822825; rs2959273; rs2938394; rs2938392; rs1151998; rs709149; rs796313; rs709156; rs1175543; rs1175540; rs2959272; rs2972162; rs1875796; rs1151996; rs1151997; rs1797912; rs709154; rs796290; rs4135359; rs4135343; rs4135260; rs4135354; rs1152002; rs4135293; rs709157; rs4135327; rs709148; rs4135358; rs709152; rs4135329; rs4135344; rs2938395; rs4135263; rs4135330; rs1177809; rs4135345; rs4135296; rs4135264; rs1151999; rs2655259; rs4135324; rs4135332; rs4135276; rs709147; rs4135356; rs709151; rs4135362; rs6442313; rs709158; rs4135282; rs4135333; rs6442312; rs4135281; rs1175541; rs1175542; rs4135340; rs4135277; rs4135350; rs2938387; rs4135266; rs4135288; rs7626560; rs4135341; rs2921193; rs4135285; rs4135361; rs4135348; rs4135326; rs2938389; rs4135347; rs4135351; rs4135261; rs2972163; rs4135337; rs4135292; rs4135286; rs709155; rs2938388; rs10510420; rs4135299; rs4135283; rs2959271; rs4135273; rs4135294; rs7645903; rs4135284; rs4135335; rs4135280; rs709150; rs4135274; rs4135357; rs4135289; rs6794024; rs709153; rs4135331; rs1152001; rs7650895; rs4135336; rs1699337; rs2959269; rs4135346; rs4135265; rs4135275; rs4135278; rs4135297; rs6782475; rs4135295; rs4135355; rs10510419; rs4135334; rs4135338; rs4135290; rs2959268; rs4135360; rs4135298; rs2292101; rs4135349; rs4135287; rs895095; rs4135267; rs4135339; rs7634282; rs4135353; rs12489347; rs17036700; rs4135262; rs1175544; rs4135291; rs4135270; rs4135268; rs4135342; rs4135328; rs4135279; rs4135325; rs4135269; rs35724001; rs7639159; rs7636854; rs3105363; rs13099828; rs13099634; rs34611445; rs7636421; rs7636598; rs7616804; rs11293844; rs7639005; rs13099078; rs35125975; rs11128604; rs2307991; rs35812816; rs9282832; rs36073622; rs7623946; rs9871668; rs12632365; rs4684103; rs35995141; rs7635807; rs6784211; rs9836965; rs35520264; rs9876829; rs4135364; rs13077495; rs13076933; rs17029002; rs4135363; rs4135300; rs17425960; rs34577159; rs9880344; rs17028996; rs35138542; rs9714363; rs35204164; rs2920502; rs28936407; rs1805192; rs1800571; rs41516544; rs28763894; rs13306746; rs41415646; rs34462475; rs34797620; rs13085211; rs35324344; rs28675782; rs34047730; rs9812856; rs34861493; rs11558404; rs34251960; rs35459073; rs2972165; rs13316783; rs34091265; rs34108955; rs2347528; rs6802327; rs35658489; rs34391565; rs34034515; rs11718894; rs34727071; rs33992296; rs2921186; rs13067060; rs2197424; rs3031383; rs28469357; rs9812859; rs35649998; rs35590426; rs13090995; rs17036428; rs17029009; rs34665399; rs34694812; rs11323214; rs5846770; rs13088728; rs35004171; rs17036277; rs9860894; rs11712531; rs34096560; rs13097936; rs13082177; rs35917766; rs36001830; rs28684849; rs17425942; rs34598704; rs17036279; rs3910864; rs34915207; rs11319327; rs35408322; rs28435743; rs2972160; rs11921075; rs13095372; rs3112394; rs4438634; rs36035284; rs11450436; rs2921187; rs34758352; rs13091468; rs10620909; rs11360916; rs10665975; rs7614873; rs17029007; rs9858703; rs11321700; rs34832349; rs35958630; rs36009235; rs11712037; rs35256588; rs35816057; rs17050720; rs10212146; rs35562755; rs10212145; rs34295844; rs7650213; rs3112392; rs35763971; rs11719187; rs35248164; rs34914033; rs7627000; rs2972161; rs9282833; rs7430836; rs11718489; rs17036183; rs13082084; rs35305483; rs35986947; rs35944176; rs2972159; rs5846769; rs17036317; rs9813120; rs11293858; rs35196430; rs9824047; rs11458097; rs11394520; rs34762200; rs2920501; rs35224214; rs34258522; rs35431607; rs35830690; rs1064061; rs7641290; rs5846771; rs35240997; rs35824198; rs1984668; rs3963365; rs11712510; rs34850546; rs28783437; rs28683092; rs34001022; rs2920504; rs10619114; rs35788455; rs17036179; rs9827378; rs35586299; rs35112713; rs11456875; rs35000407; rs6787534; rs12106668; rs13091131; rs34856298; rs34132377; rs13095882; rs6795126; rs2938393; rs35403303; rs11373145; rs36052770; rs13316883; rs10587216; rs3773360; rs7612778; rs11451254; rs35474352; rs4371498; rs11324808; rs35789821; rs9837762; rs11372505; rs13071893; rs2921192; rs35942115; rs11287877; rs1152000; rs11280439; rs11337165; rs35434486; rs1797879; rs11346922; rs35190152; rs41311317; rs10540594; rs35649722; rs10049123; rs34692304; rs1699373; rs10602525; rs34493672; rs34334895; rs3821614; rs9837916; rs1797878; rs12629147; rs9843706; rs13064303; rs35491663; rs35258697; rs10643169; rs4684852; rs2938391; rs35632413; rs35218291; rs3127609; rs5846772; rs3105364; rs13095707; rs34897095; rs2938390; rs35121790; rs6147711; rs13075164; rs4684851; rs34151900; rs35880011; rs9833647; rs10614129; rs1987536; rs11427297; rs35082382; rs36025945; rs13095719; rs36121170; rs3836371; rs34898812; rs34318338; rs11914306; rs3127608; rs35948804; rs11344254; rs796289; rs11377897; rs35598149; rs10575755; rs36055981; rs11368226; rs11713869; rs10048953; rs11446342; rs1797895; rs35691895; rs41484149; rs1185785; rs11329101; rs3773357; rs3210577; rs41293379; rs28848197; rs34241217; rs7627540; rs3103310; rs4684102; rs35168570; rs41491647; rs10222537; rs1152003; rs1152004; rs1152005; rs1175545; rs1181795; rs13066537; rs13090265; rs1663813; rs17036753; rs1797877; rs2920500; rs2920503; rs2960421; rs4498025; rs4684104; rs6790976; rs709159; rs7609637; rs7616847; rs7622847; rs7643499; rs9827787; rs9831245; rs9831411; rs9833097; rs9837686; rs9868474

# Macromolecular_Interacting_Partner_19_General_References:
9065481; 8702406; 9144532; 7787419; 9356045; 8706692; 10681503; 11971969; 10882139; 9425261; 9753710; 10407229; 10394368; 10622252; 11788685

# Macromolecular_Interacting_Partner_19_References:
14739357; 16112107; 16927016

# Macromolecular_Interacting_Partner_20_ID:
7659

# Macromolecular_Interacting_Partner_20_Name:
Cyclin-dependent kinase inhibitor 1

# Macromolecular_Interacting_Partner_20_Synonyms:
p21; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6

# Macromolecular_Interacting_Partner_20_Gene_Name:
CDKN1A

# Macromolecular_Interacting_Partner_20_Protein_Sequence:
>Cyclindependent kinase inhibitor 1
MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLE
GDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLV
PRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP

# Macromolecular_Interacting_Partner_20_Number_of_Residues:
164

# Macromolecular_Interacting_Partner_20_Molecular_Weight:
18120

# Macromolecular_Interacting_Partner_20_Theoretical_pI:
8.50

# Macromolecular_Interacting_Partner_20_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  kinase inhibitor activity
Function:  protein kinase inhibitor activity
Function:  cyclin-dependent protein kinase inhibitor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of cellular physiological process
Process:  regulation of cell cycle
Process:  regulation of progression through cell cycle
Process:  negative regulation of progression through cell cycle
Process:  cell cycle arrest
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_20_General_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Specific_Function:
May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression

# Macromolecular_Interacting_Partner_20_Pathway:
Not Available

# Macromolecular_Interacting_Partner_20_Reaction:
Not Available

# Macromolecular_Interacting_Partner_20_Pfam_Domain_Function:
PF02234:CDI

# Macromolecular_Interacting_Partner_20_Signals:
None

# Macromolecular_Interacting_Partner_20_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_20_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_20_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_20_GenBank_ID_Protein:
425143

# Macromolecular_Interacting_Partner_20_SwissProt_ID:
CDN1A_HUMAN (P38936)

# Macromolecular_Interacting_Partner_20_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_20_Genecard_id:
CDKN1A

# Macromolecular_Interacting_Partner_20_Geneatlas_id:
CDKN1A

# Macromolecular_Interacting_Partner_20_hgnc_id:
HGNC:1784

# Macromolecular_Interacting_Partner_20_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_20_Subcellular_Location:
Cytoplasm. Nucleus

# Macromolecular_Interacting_Partner_20_Gene_Sequence:
>495 bp
ATGTCAGAACCGGCTGGGGATGTCCGTCAGAACCCATGCGGCAGCAAGGCCTGCCGCCGC
CTCTTCGGCCCAGTGGACAGCGAGCAGCTGAGCCGCGACTGTGATGCGCTAATGGCGGGC
TGCATCCAGGAGGCCCGTGAGCGATGGAACTTCGACTTTGTCACCGAGACACCACTGGAG
GGTGACTTCGCCTGGGAGCGTGTGCGGGGCCTTGGCCTGCCCAAGCTCTACCTTCCCACG
GGGCCCCGGCGAGGCCGGGATGAGTTGGGAGGAGGCAGGCGGCCTGGCACCTCACCTGCT
CTGCTGCAGGGGACAGCAGAGGAAGACCATGTGGACCTGTCACTGTCTTGTACCCTTGTG
CCTCGCTCAGGGGAGCAGGCTGAAGGGTCCCCAGGTGGACCTGGAGACTCTCAGGGTCGA
AAACGGCGGCAGACCAGCATGACAGATTTCTACCACTCCAAACGCCGGCTGATCTTCTCC
AAGAGGAAGCCCTAA

# Macromolecular_Interacting_Partner_20_GenBank_ID_Gene:
L25610

# Macromolecular_Interacting_Partner_20_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_20_Locus:
6p21.2

# Macromolecular_Interacting_Partner_20_SNPs:
Not Available

# Macromolecular_Interacting_Partner_20_General_References:
8242751; 8242752; 8259214; 8125163; 7655464; 14574404; 10753973; 11463845; 8861913

# Macromolecular_Interacting_Partner_20_References:
12806965; 14559818; 14690797; 14750171

# Macromolecular_Interacting_Partner_21_ID:
7661

# Macromolecular_Interacting_Partner_21_Name:
Thrombopoietin precursor

# Macromolecular_Interacting_Partner_21_Synonyms:
Megakaryocyte colony-stimulating factor; Myeloproliferative leukemia virus oncogene ligand; C-mpl ligand; ML; Megakaryocyte growth and development factor; MGDF

# Macromolecular_Interacting_Partner_21_Gene_Name:
THPO

# Macromolecular_Interacting_Partner_21_Protein_Sequence:
>Thrombopoietin precursor
MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT
AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL
DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP
TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG

# Macromolecular_Interacting_Partner_21_Number_of_Residues:
353

# Macromolecular_Interacting_Partner_21_Molecular_Weight:
37823

# Macromolecular_Interacting_Partner_21_Theoretical_pI:
9.86

# Macromolecular_Interacting_Partner_21_GO_Classification:
>>>
Function:  cytokine activity
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell proliferation
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_21_General_Function:
Not Available

# Macromolecular_Interacting_Partner_21_Specific_Function:
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets

# Macromolecular_Interacting_Partner_21_Pathway:
Not Available

# Macromolecular_Interacting_Partner_21_Reaction:
Not Available

# Macromolecular_Interacting_Partner_21_Pfam_Domain_Function:
PF00758:EPO_TPO

# Macromolecular_Interacting_Partner_21_Signals:
1-21

# Macromolecular_Interacting_Partner_21_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_21_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_21_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_21_GenBank_ID_Protein:
506827

# Macromolecular_Interacting_Partner_21_SwissProt_ID:
TPO_HUMAN (P40225)

# Macromolecular_Interacting_Partner_21_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_21_Genecard_id:
THPO

# Macromolecular_Interacting_Partner_21_Geneatlas_id:
THPO

# Macromolecular_Interacting_Partner_21_hgnc_id:
HGNC:11795

# Macromolecular_Interacting_Partner_21_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_21_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_21_Gene_Sequence:
>1062 bp
ATGGAGCTGACTGAATTGCTCCTCGTGGTCATGCTTCTCCTAACTGCAAGGCTAACGCTG
TCCAGCCCGGCTCCTCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCC
CATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTC
CTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAG
GCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGA
CAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTC
CTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACA
GCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTG
CGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGCGGGCCCCACCCACCACA
GCTGTCCCCAGCAGAACCTCTCTAGTCCTCACACTGAACGAGCTCCCAAACAGGACTTCT
GGATTGTTGGAGACAAACTTCACTGCCTCAGCCAGAACTACTGGCTCTGGGCTTCTGAAG
TGGCAGCAGGGATTCAGAGCCAAGATTCCTGGTCTGCTGAACCAAACCTCCAGGTCCCTG
GACCAAATCCCCGGATACCTGAACAGGATACACGAACTCTTGAATGGAACTCGTGGACTC
TTTCCTGGACCCTCACGCAGGACCCTAGGAGCCCCGGACATTTCCTCAGGAACATCAGAC
ACAGGCTCCCTGCCACCCAACCTCCAGCCTGGATATTCTCCTTCCCCAACCCATCCTCCT
ACTGGACAGTATACGCTCTTCCCTCTTCCACCCACCTTGCCCACCCCTGTGGTCCAGCTC
CACCCCCTGCTTCCTGACCCTTCTGCTCCAACGCCCACCCCTACCAGCCCTCTTCTAAAC
ACATCCTACACCCACTCCCAGAATCTGTCTCAGGAAGGGTAA

# Macromolecular_Interacting_Partner_21_GenBank_ID_Gene:
L33410

# Macromolecular_Interacting_Partner_21_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_21_Locus:
3q27

# Macromolecular_Interacting_Partner_21_SNPs:
rs956732; rs6141; rs13084750; rs3792299; rs3804618; rs2280740; rs10513797; rs6142; rs16858759; rs13091574; rs952982; rs1126665; rs1042346; rs1126664; rs35794435; rs1042348; rs35796121; rs13084357; rs2700319; rs34623301; rs2700322; rs2700320; rs34037653; rs2464115; rs10702924; rs9870912; rs36062626; rs28550009; rs13094594; rs16858778; rs16858780; rs1802869; rs2239856; rs2855306; rs34052076; rs34147749; rs35087408; rs35633216; rs35929225; rs3749228; rs3749229; rs4912484; rs4912485; rs4912486; rs4912487; rs7615189; rs885838

# Macromolecular_Interacting_Partner_21_General_References:
8202154; 8020099; 7809166; 7926023; 7849319; 8537317; 7822271

# Macromolecular_Interacting_Partner_21_References:
15903240; 16169764

# Macromolecular_Interacting_Partner_22_ID:
7666

# Macromolecular_Interacting_Partner_22_Name:
Signal transducer and activator of transcription 1-alpha/beta

# Macromolecular_Interacting_Partner_22_Synonyms:
Transcription factor ISGF-3 components p91/p84

# Macromolecular_Interacting_Partner_22_Gene_Name:
STAT1

# Macromolecular_Interacting_Partner_22_Protein_Sequence:
>Signal transducer and activator of transcription 1alpha/beta
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL
LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ
RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR
EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK
RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV
LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV
KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN
EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE
PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT
RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL
LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP
ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT
DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV

# Macromolecular_Interacting_Partner_22_Number_of_Residues:
750

# Macromolecular_Interacting_Partner_22_Molecular_Weight:
87336

# Macromolecular_Interacting_Partner_22_Theoretical_pI:
5.92

# Macromolecular_Interacting_Partner_22_GO_Classification:
>>>
Function:  signal transducer activity
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_22_General_Function:
Not Available

# Macromolecular_Interacting_Partner_22_Specific_Function:
Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state

# Macromolecular_Interacting_Partner_22_Pathway:
Not Available

# Macromolecular_Interacting_Partner_22_Reaction:
Not Available

# Macromolecular_Interacting_Partner_22_Pfam_Domain_Function:
PF00017:SH2;
PF01017:STAT_alpha;
PF02864:STAT_bind;
PF02865:STAT_int

# Macromolecular_Interacting_Partner_22_Signals:
None

# Macromolecular_Interacting_Partner_22_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_22_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_22_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_22_GenBank_ID_Protein:
2281071

# Macromolecular_Interacting_Partner_22_SwissProt_ID:
STAT1_HUMAN (P42224)

# Macromolecular_Interacting_Partner_22_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_22_Genecard_id:
STAT1

# Macromolecular_Interacting_Partner_22_Geneatlas_id:
STAT1

# Macromolecular_Interacting_Partner_22_hgnc_id:
HGNC:11362

# Macromolecular_Interacting_Partner_22_PDB_ID:
1YVL

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_22_Subcellular_Location:
Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta

# Macromolecular_Interacting_Partner_22_Gene_Sequence:
>2253 bp
ATGTCTCAGTGGTACGAACTTCAGCAGCTTGACTCAAAATTCCTGGAGCAGGTTCACCAG
CTTTATGATGACAGTTTTCCCATGGAAATCAGACAGTACCTGGCACAGTGGTTAGAAAAG
CAAGACTGGGAGCACGCTGCCAATGATGTTTCATTTGCCACCATCCGTTTTCATGACCTC
CTGTCACAGCTGGATGATCAATATAGTCGCTTTTCTTTGGAGAATAACTTCTTGCTACAG
CATAACATAAGGAAAAGCAAGCGTAATCTTCAGGATAATTTTCAGGAAGACCCAATCCAG
ATGTCTATGATCATTTACAGCTGTCTGAAGGAAGAAAGGAAAATTCTGGAAAACGCCCAG
AGATTTAATCAGGCTCAGTCGGGGAATATTCAGAGCACAGTGATGTTAGACAAACAGAAA
GAGCTTGACAGTAAAGTCAGAAATGTGAAGGACAAGGTTATGTGTATAGAGCATGAAATC
AAGAGCCTGGAAGATTTACAAGATGAATATGACTTCAAATGCAAAACCTTGCAGAACAGA
GAACACGAGACCAATGGTGTGGCAAAGAGTGATCAGAAACAAGAACAGCTGTTACTCAAG
AAGATGTATTTAATGCTTGACAATAAGAGAAAGGAAGTAGTTCACAAAATAATAGAGTTG
CTGAATGTCACTGAACTTACCCAGAATGCCCTGATTAATGATGAACTAGTGGAGTGGAAG
CGGAGACAGCAGAGCGCCTGTATTGGGGGGCCGCCCAATGCTTGCTTGGATCAGCTGCAG
AACTGGTTCACTATAGTTGCGGAGAGTCTGCAGCAAGTTCGGCAGCAGCTTAAAAAGTTG
GAGGAATTGGAACAGAAATACACCTACGAACATGACCCTATCACAAAAAACAAACAAGTG
TTATGGGACCGCACCTTCAGTCTTTTCCAGCAGCTCATTCAGAGCTCGTTTGTGGTGGAA
AGACAGCCCTGCATGCCAACGCACCCTCAGAGGCCGCTGGTCTTGAAGACAGGGGTCCAG
TTCACTGTGAAGTTGAGACTGTTGGTGAAATTGCAAGAGCTGAATTATAATTTGAAAGTC
AAAGTCTTATTTGATAAAGATGTGAATGAGAGAAATACAGTAAAAGGATTTAGGAAGTTC
AACATTTTGGGCACGCACACAAAAGTGATGAACATGGAGGAGTCCACCAATGGCAGTCTG
GCGGCTGAATTTCGGCACCTGCAATTGAAAGAACAGAAAAATGCTGGCACCAGAACGAAT
GAGGGTCCTCTCATCGTTACTGAAGAGCTTCACTCCCTTAGTTTTGAAACCCAATTGTGC
CAGCCTGGTTTGGTAATTGACCTCGAGACGACCTCTCTGCCCGTTGTGGTGATCTCCAAC
GTCAGCCAGCTCCCGAGCGGTTGGGCCTCCATCCTTTGGTACAACATGCTGGTGGCGGAA
CCCAGGAATCTGTCCTTCTTCCTGACTCCACCATGTGCACGATGGGCTCAGCTTTCAGAA
GTGCTGAGTTGGCAGTTTTCTTCTGTCACCAAAAGAGGTCTCAATGTGGACCAGCTGAAC
ATGTTGGGAGAGAAGCTTCTTGGTCCTAACGCCAGCCCCGATGGTCTCATTCCGTGGACG
AGGTTTTGTAAGGAAAATATAAATGATAAAAATTTTCCCTTCTGGCTTTGGATTGAAAGC
ATCCTAGAACTCATTAAAAAACACCTGCTCCCTCTCTGGAATGATGGGTGCATCATGGGC
TTCATCAGCAAGGAGCGAGAGCGTGCCCTGTTGAAGGACCAGCAGCCGGGGACCTTCCTG
CTGCGGTTCAGTGAGAGCTCCCGGGAAGGGGCCATCACATTCACATGGGTGGAGCGGTCC
CAGAACGGAGGCGAACCTGACTTCCATGCGGTTGAACCCTACACGAAGAAAGAACTTTCT
GCTGTTACTTTCCCTGACATCATTCGCAATTACAAAGTCATGGCTGCTGAGAATATTCCT
GAGAATCCCCTGAAGTATCTGTATCCAAATATTGACAAAGACCATGCCTTTGGAAAGTAT
TACTCCAGGCCAAAGGAAGCACCAGAGCCAATGGAACTTGATGGCCCTAAAGGAACTGGA
TATATCAAGACTGAGTTGATTTCTGTGTCTGAAGTTCACCCTTCTAGACTTCAGACCACA
GACAACCTGCTCCCCATGTCTCCTGAGGAGTTTGACGAGGTGTCTCGGATAGTGGGCTCT
GTAGAATTCGACAGTATGATGAACACAGTATAG

# Macromolecular_Interacting_Partner_22_GenBank_ID_Gene:
M97935

# Macromolecular_Interacting_Partner_22_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_22_Locus:
2q32.2

# Macromolecular_Interacting_Partner_22_SNPs:
rs34255470; rs2066802; rs13029532; rs36077929; rs11305; rs16833172; rs6745710; rs2066798; rs2030171; rs908598; rs2066804; rs1914408; rs4853536; rs1547550; rs12693590; rs7597768; rs10173099; rs13010343; rs7562024; rs4853535; rs10199181; rs13395505; rs2280232; rs2066805; rs6718902; rs2280235; rs12693591; rs41495745; rs41388645; rs2280234; rs16833155; rs11887394; rs11885069; rs11887698; rs41511150; rs41514544; rs41427447; rs16833157; rs41430444; rs4327257; rs3755312; rs16833143; rs13012785; rs17817076; rs41366946; rs11677408; rs11693463; rs9789700; rs3771300; rs3755311; rs2066795; rs1033248; rs11904548; rs2280233; rs16833141; rs10167514; rs2066797; rs6734110; rs2066799; rs2066806; rs2066794; rs16833144; rs41440051; rs10183196; rs16824035; rs13390894; rs12464143; rs9789428; rs11688154; rs4853533; rs16833160; rs41514553; rs16833147; rs2066800; rs4853537; rs13029247; rs17749316; rs12475993; rs4853532; rs13005843; rs7575823; rs34997637; rs7565237; rs16833164; rs10179199; rs6711082; rs2066793; rs16833142; rs11679212; rs41375144; rs2066803; rs7576984; rs7562400; rs2066801; rs16833146; rs10190333; rs11894425; rs1400657; rs12468579; rs1467198; rs12693589; rs4853455; rs11678454; rs17817900; rs12693588; rs1467199; rs10195683; rs36234015; rs10208033; rs36234022; rs11689880; rs11682932; rs16833126; rs11549696; rs41473544; rs1803838; rs41509946; rs35364817; rs35098579; rs41270237; rs41324145; rs41476445; rs41363648; rs34099150; rs3215260; rs5837214; rs35110557; rs41481847; rs34979992; rs34692732; rs3215258; rs11549697; rs11549698; rs41330944; rs41390345; rs11315624; rs41499444; rs35796119; rs41531551; rs4306740; rs4853538; rs41378045; rs41350748; rs41453045; rs41413547; rs41381545; rs41429347; rs41379748; rs41446247; rs34321682; rs7422639; rs41450049; rs41384345; rs41339847; rs11386507; rs41507345; rs41454144; rs41429349; rs41384750; rs41333947; rs2066796; rs41457547; rs41474144; rs7577007; rs13027303; rs41427344; rs36021646; rs12477076; rs35908641; rs41383548; rs41392944; rs41359252; rs41417844; rs41411149; rs41508653; rs41373544; rs41464253; rs5837215; rs41364950; rs41504347; rs1914407; rs41505447; rs41330646; rs7355231; rs34287013; rs41438845; rs41454245; rs41348952; rs41411249; rs41463952; rs41449550; rs41488044; rs7589233; rs3830526; rs34589515; rs41499349; rs10635466; rs35378485; rs34975356; rs41470846; rs41504449; rs41515945; rs4853534; rs41379347; rs35046975; rs41523450; rs41402551; rs36014758; rs34230248; rs34723079; rs13410645; rs11546470; rs41533248; rs35635960; rs10183400; rs41497045; rs34465916; rs41379447; rs36116009; rs35669756; rs5837216; rs35789081; rs35284787; rs35178261; rs35085810; rs35192272; rs41497448; rs952798; rs10166027; rs41484944; rs41421850; rs41411845; rs34945497; rs41371944; rs13027915; rs36234021; rs41325845; rs13027923; rs10174720; rs36234019; rs41385444; rs41452847; rs41457850; rs34480951; rs10437; rs1168; rs11690599; rs11692579; rs11884122; rs11885168; rs11899865; rs12469810; rs12987796; rs13000734; rs13020076; rs13035504; rs1400658; rs1546646; rs16833113; rs16833123; rs16833177; rs17748980; rs17817966; rs3088307; rs35890674; rs6712504; rs6751855; rs6752638; rs7558921; rs867637; rs883844

# Macromolecular_Interacting_Partner_22_General_References:
1502203; 7885841; 7657660; 7543024; 11442634; 10702714; 9630226

# Macromolecular_Interacting_Partner_22_References:
14517348

# Macromolecular_Interacting_Partner_23_ID:
7434

# Macromolecular_Interacting_Partner_23_Name:
Caspase-3 precursor

# Macromolecular_Interacting_Partner_23_Synonyms:
CASP-3; Apopain; Cysteine protease CPP32; Yama protein; CPP-32; SREBP cleavage activity 1; SCA-1[Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]

# Macromolecular_Interacting_Partner_23_Gene_Name:
CASP3

# Macromolecular_Interacting_Partner_23_Protein_Sequence:
>Caspase3 precursor
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

# Macromolecular_Interacting_Partner_23_Number_of_Residues:
277

# Macromolecular_Interacting_Partner_23_Molecular_Weight:
31608

# Macromolecular_Interacting_Partner_23_Theoretical_pI:
6.51

# Macromolecular_Interacting_Partner_23_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  cysteine-type endopeptidase activity
Function:  caspase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_23_General_Function:
Not Available

# Macromolecular_Interacting_Partner_23_Specific_Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin

# Macromolecular_Interacting_Partner_23_Pathway:
Not Available

# Macromolecular_Interacting_Partner_23_Reaction:
Not Available

# Macromolecular_Interacting_Partner_23_Pfam_Domain_Function:
PF00656:Peptidase_C14

# Macromolecular_Interacting_Partner_23_Signals:
None

# Macromolecular_Interacting_Partner_23_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_23_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_23_EC_Link:
EC 3.4.22.56

# Macromolecular_Interacting_Partner_23_GenBank_ID_Protein:
561666

# Macromolecular_Interacting_Partner_23_SwissProt_ID:
CASP3_HUMAN (P42574)

# Macromolecular_Interacting_Partner_23_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_23_Genecard_id:
CASP3

# Macromolecular_Interacting_Partner_23_Geneatlas_id:
CASP3

# Macromolecular_Interacting_Partner_23_hgnc_id:
HGNC:1504

# Macromolecular_Interacting_Partner_23_PDB_ID:
1CP3

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_23_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_23_Gene_Sequence:
>834 bp
ATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATC
ATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGAT
TATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGA
ATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAAC
TTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATG
CGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGC
CATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACA
AACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATT
CAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGAT
GACATGGCGTGTCATAAAATACCAGTGGATGCCGACTTCTTGTATGCATACTCCACAGCA
CCTGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGT
GCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAAC
CGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAA
CAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAA

# Macromolecular_Interacting_Partner_23_GenBank_ID_Gene:
U13737

# Macromolecular_Interacting_Partner_23_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_23_Locus:
4q34

# Macromolecular_Interacting_Partner_23_SNPs:
rs35578277; rs1049210; rs35566035; rs1049253; rs2720378; rs3087455; rs6948; rs4647640; rs4647610; rs4647617; rs4647642; rs4647634; rs4647611; rs4647620; rs1049216; rs4647641; rs4647618; rs4647609; rs4647694; rs8549; rs4647698; rs4647614; rs4647621; rs4647622; rs4647616; rs4647633; rs4647643; rs4647630; rs34184817; rs4647647; rs35422505; rs4647624; rs4647626; rs4647696; rs4647606; rs4647631; rs4647646; rs4647607; rs4647625; rs34022730; rs35439719; rs2720377; rs4647632; rs4647628; rs2310103; rs34309992; rs4647629; rs4647644; rs4647636; rs2019978; rs2705891; rs1830254; rs2720376; rs2696056; rs4241793; rs4647667; rs4647688; rs4647663; rs1405942; rs4647652; rs1405938; rs4647662; rs2705901; rs1405944; rs4647671; rs4647665; rs2696057; rs4647693; rs4647672; rs2705897; rs4647669; rs4647673; rs4647692; rs4647674; rs4647666; rs4647686; rs4647683; rs4647690; rs4647657; rs4987118; rs4647679; rs4647670; rs4987119; rs4647658; rs4647684; rs4647675; rs4647650; rs34319440; rs4647685; rs2696048; rs4647651; rs4647676; rs4647687; rs4647655; rs13128316; rs13435139; rs4647704; rs4647700; rs12646257; rs4647701; rs4647623; rs4647635; rs10028033; rs12641602; rs13101834; rs11380373; rs4647695; rs34119644; rs2705892; rs34858791; rs35063555; rs4647699; rs4647639; rs34095700; rs4647619; rs13102911; rs4647645; rs4647612; rs13101835; rs4647637; rs4647638; rs2705893; rs4647649; rs2696060; rs10028034; rs4647697; rs4647613; rs35978407; rs4647608; rs4647615; rs28418774; rs4647648; rs1802667; rs34568867; rs7442206; rs4647682; rs4647656; rs4647681; rs4647668; rs4647677; rs4647678; rs4647691; rs35261594; rs4647689; rs4647653; rs35966919; rs34740772; rs4647659; rs41314884; rs9997231; rs3215361; rs4647661; rs4647654; rs10014306; rs10660141; rs4647664; rs4647660; rs4647680; rs10034836; rs35094553; rs9715122; rs4647705; rs34083547; rs9715863; rs4647702; rs4647703; rs11930666; rs12108497; rs12507711; rs13108061; rs13435890; rs1405937; rs2696058; rs2696059; rs2705881; rs2705882; rs2705900; rs2720388; rs2720389; rs34605630; rs4647600; rs4647602; rs4647603; rs4647605; rs4861629; rs4862396; rs4862399; rs7673753; rs7674164; rs7687648; rs9685847

# Macromolecular_Interacting_Partner_23_General_References:
7983002; 7774019; 7596430; 8673606; 9045680; 10821855; 8755496; 8696339

# Macromolecular_Interacting_Partner_23_References:
12618885; 15504750; 15528887; 15583047

# Macromolecular_Interacting_Partner_24_ID:
6829

# Macromolecular_Interacting_Partner_24_Name:
Mitogen-activated protein kinase 10

# Macromolecular_Interacting_Partner_24_Synonyms:
Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3; MAP kinase p49 3F12

# Macromolecular_Interacting_Partner_24_Gene_Name:
MAPK10

# Macromolecular_Interacting_Partner_24_Protein_Sequence:
>Mitogenactivated protein kinase 10
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR

# Macromolecular_Interacting_Partner_24_Number_of_Residues:
464

# Macromolecular_Interacting_Partner_24_Molecular_Weight:
52586

# Macromolecular_Interacting_Partner_24_Theoretical_pI:
6.78

# Macromolecular_Interacting_Partner_24_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_24_General_Function:
Not Available

# Macromolecular_Interacting_Partner_24_Specific_Function:
Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity

# Macromolecular_Interacting_Partner_24_Pathway:
Not Available

# Macromolecular_Interacting_Partner_24_Reaction:
Not Available

# Macromolecular_Interacting_Partner_24_Pfam_Domain_Function:
PF00069:Pkinase

# Macromolecular_Interacting_Partner_24_Signals:
None

# Macromolecular_Interacting_Partner_24_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_24_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_24_EC_Link:
EC 2.7.11.24

# Macromolecular_Interacting_Partner_24_GenBank_ID_Protein:
468151

# Macromolecular_Interacting_Partner_24_SwissProt_ID:
MK10_HUMAN (P53779)

# Macromolecular_Interacting_Partner_24_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_24_Genecard_id:
MAPK10

# Macromolecular_Interacting_Partner_24_Geneatlas_id:
MAPK10

# Macromolecular_Interacting_Partner_24_hgnc_id:
HGNC:6872

# Macromolecular_Interacting_Partner_24_PDB_ID:
1JNK

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_24_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_24_Gene_Sequence:
>1269 bp
ATGAGCCTCCATTTCTTATACTACTGCAGTGAACCAACATTGGATGTGAAAATTGCCTTT
TGTCAGGGATTCGATAAACAAGTGGATGTGTCATATATTGCCAAACATTACAACATGAGC
AAAAGCAAAGTTGACAACCAGTTCTACAGTGTGGAAGTGGGAGACTCAACCTTCACAGTT
CTCAAGCGCTACCAGAATCTAAAGCCTATTGGCTCTGGGGCTCAGGGCATAGTTTGTGCC
GCGTATGATGCTGTCCTTGACAGAAATGTGGCCATTAAGAAGCTCAGCAGACCCTTTCAG
AACCAAACACATGCCAAGAGAGCGTACCGGGAGCTGGTCCTCATGAAGTGTGTGAACCAT
AAAAACATTATTAGTTTATTAAATGTCTTCACACCCCAGAAAACGCTGGAGGAGTTCCAA
GATGTTTACTTAGTAATGGAACTGATGGATGCCAACTTATGTCAAGTGATTCAGATGGAA
TTAGACCATGAGCGAATGTCTTACCTGCTGTACCAAATGTTGTGTGGCATTAAGCACCTC
CATTCTGCTGGAATTATTCACAGGGATTTAAAACCAAGTAACATTGTAGTCAAGTCTGAT
TGCACATTGAAAATCCTGGACTTTGGACTGGCCAGGACAGCAGGCACAAGCTTCATGATG
ACTCCATATGTGGTGACACGTTATTACAGAGCCCCTGAGGTCATCCTGGGGATGGGCTAC
AAGGAGAACGTGGATATATGGTCTGTGGGATGCATTATGGGAGAAATGGTTCGCCACAAA
ATCCTCTTTCCAGGAAGGGACTATATTGACCAGTGGAATAAGGTAATTGAACAACTAGGA
ACACCATGTCCAGAATTCATGAAGAAATTGCAACCCACAGTAAGAAACTATGTGGAGAAT
CGGCCCAAGTATGCGGGACTCACCTTCCCCAAACTCTTCCCAGATTCCCTCTTCCCAGCG
GACTCCGAGCACAATAAACTCAAAGCCAGCCAAGCCAGGGACTTGTTGTCAAAGATGCTA
GTGATTGACCCAGCAAAAAGAATATCAGTGGACGACGCCTTACAGCATCCCTACATCAAC
GTCTGGTATGACCCAGCCGAAGTGGAGGCGCCTCCACCTCAGATATATGACAAGCAGTTG
GATGAAAGAGAACACACAATTGAAGAATGGAAAGAACTTATCTACAAGGAAGTAATGAAT
TCAGAAGAAAAGACTAAAAATGGTGTAGTAAAAGGACAGCCTTCTCCTTCAGCACAGGTG
CAGCAGTGA

# Macromolecular_Interacting_Partner_24_GenBank_ID_Gene:
U07620

# Macromolecular_Interacting_Partner_24_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_24_Locus:
4q22.1-q23

# Macromolecular_Interacting_Partner_24_SNPs:
rs1460763; rs1460767; rs1031738; rs2869444; rs1460759; rs2199308; rs1460769; rs2199309; rs1108429; rs2904101; rs1031737; rs2869438; rs2869421; rs1460756; rs1460753; rs2290882; rs4611890; rs10008238; rs7670728; rs11097100; rs6810895; rs10010011; rs6825707; rs10029339; rs4693145; rs4693142; rs1903360; rs11097104; rs11097099; rs7655217; rs1599313; rs6531910; rs12499006; rs1460760; rs10213453; rs7349681; rs6531906; rs6855169; rs7694034; rs7666454; rs12650052; rs12505566; rs12512375; rs6531914; rs6825506; rs7699555; rs11932806; rs7687771; rs11943376; rs6810839; rs9884127; rs12507758; rs1460751; rs10004539; rs6531925; rs4132490; rs6817452; rs2904094; rs4385018; rs1903361; rs6858306; rs12641387; rs12509960; rs1031739; rs3926499; rs12498980; rs2869424; rs1460758; rs1460766; rs6829923; rs10021706; rs6531913; rs4693135; rs6531921; rs4235080; rs2904095; rs1599314; rs10213444; rs6531909; rs4693139; rs6839160; rs1460750; rs6845742; rs9999403; rs6531926; rs6531924; rs6531916; rs6852305; rs2290881; rs12646571; rs11097109; rs11938088; rs9990599; rs11736313; rs1460752; rs7654796; rs4608765; rs12505959; rs6832259; rs7666231; rs1460757; rs6829870; rs2904097; rs6811046; rs10856859; rs6531911; rs9307018; rs2904090; rs2869437; rs6531905; rs6828947; rs7678480; rs9994931; rs12513293; rs958; rs12513374; rs4235079; rs7680934; rs4693765; rs12648265; rs10010952; rs2904096; rs2199307; rs4597789; rs7669060; rs12511071; rs6823664; rs2869435; rs10011429; rs11939109; rs6531923; rs7656914; rs6844365; rs6531907; rs6827698; rs11097103; rs11097110; rs10213451; rs7665868; rs12505595; rs6845605; rs12640395; rs2869431; rs1460761; rs4693766; rs6531915; rs7695155; rs12512698; rs7667999; rs7690384; rs11946235; rs10516768; rs7669487; rs2869436; rs12507513; rs7684258; rs12505532; rs17451111; rs1466380; rs17409925; rs6825521; rs1460754; rs17253274; rs12505336; rs7694920; rs6826702; rs2904099; rs7684081; rs11930495; rs13115429; rs6822338; rs11941150; rs7674849; rs6531922; rs2869432; rs13115172; rs12508545; rs6531918; rs2035056; rs12503051; rs11097107; rs6851183; rs17011890; rs7695707; rs7688633; rs12508801; rs11097108; rs11941484; rs4114893; rs7699065; rs7669675; rs6531927; rs2904105; rs2869433; rs7677400; rs12646021; rs11929810; rs13129883; rs13146797; rs11929779; rs12498923; rs6821819; rs11726269; rs11942064; rs12513237; rs10516771; rs4693763; rs13111170; rs11097098; rs12511667; rs12640392; rs7699047; rs17011519; rs6842671; rs17449485; rs11947870; rs6531928; rs7684469; rs13104178; rs10516774; rs12508939; rs7683561; rs6852494; rs6531917; rs17417318; rs6851604; rs7657056; rs13132206; rs6844363; rs7699333; rs13138286; rs11944466; rs12501551; rs17409687; rs1380922; rs9654156; rs12510302; rs11929783; rs17011893; rs11935211; rs17011645; rs11946258; rs9997633; rs17011756; rs12645370; rs7685419; rs4488910; rs6829766; rs7668374; rs4693143; rs17011584; rs7688651; rs2126021; rs6856688; rs12508372; rs11725943; rs12505800; rs6531912; rs4693140; rs12511114; rs7684518; rs17011445; rs7683909; rs10516773; rs10003259; rs10516770; rs2035057; rs17409311; rs10030319; rs7655797; rs12502371; rs12508579; rs11097102; rs2904102; rs2869439; rs12508286; rs7678392; rs10026060; rs12644920; rs7678691; rs10516769; rs11932102; rs9654157; rs13130598; rs1599312; rs4693144; rs6844343; rs7691626; rs7699105; rs12500132; rs10034428; rs17449015; rs7440491; rs7656010; rs2869422; rs11737795; rs6849834; rs12510373; rs4613534; rs4389539; rs17011705; rs922195; rs17011617; rs12513122; rs6531904; rs12513353; rs1460755; rs7685683; rs10516772; rs2904093; rs7698274; rs10022904; rs4693141; rs11097106; rs12504127; rs7437117; rs12500543; rs9307016; rs4693761; rs16996040; rs12501743; rs17418062; rs17011654; rs7684570; rs7679269; rs6827098; rs12504929; rs13146802; rs17011479; rs17011870; rs17011564; rs4693764; rs11726550; rs17011659; rs7696982; rs12649297; rs17011402; rs4693137; rs17011489; rs10016847; rs11725624; rs6830872; rs17011568; rs17415651; rs17011516; rs7684758; rs17450224; rs7677251; rs12500319; rs6814005; rs17011467; rs6847300; rs12646076; rs17452273; rs17011913; rs3733367; rs17011621; rs10035072; rs7689808; rs1380923; rs769378; rs6853248; rs9715454; rs10019269; rs17011457; rs7687046; rs6827405; rs2869423; rs1841427; rs6843457; rs11097101; rs11943324; rs9762809; rs17409527; rs17449147; rs10010751; rs1460762; rs10009161; rs12504532; rs17011731; rs6836561; rs17011611; rs17011847; rs10025305; rs7687161; rs12651511; rs17011653; rs7696980; rs17011419; rs7661197; rs7663388; rs6827483; rs10028202; rs6826762; rs6816691; rs9762806; rs17011588; rs17011421; rs17011575; rs12331353; rs7687972; rs12505443; rs7693923; rs6832461; rs17011396; rs17011409; rs7662140; rs6851072; rs4449380; rs12499209; rs17011458; rs10030225; rs17011492; rs9997175; rs12511602; rs17011592; rs17011547; rs11943129; rs2869430; rs17011630; rs1841426; rs10031237; rs17418221; rs17409478; rs12509902; rs11931871; rs17011649; rs6831576; rs12507860; rs17011487; rs769377; rs9762814; rs17011843; rs17417758; rs17408832; rs17011623; rs12503520; rs6847482; rs10034589; rs17011472; rs7696316; rs12640131; rs7654907; rs17011607; rs17011400; rs1903362; rs17011460; rs12508926; rs6818726; rs1460765; rs4521313; rs13112020; rs12509769; rs17011577; rs17409637; rs17011875; rs10026338; rs12646706; rs10470881; rs17449582; rs7691172; rs13140626; rs12502087; rs17011410; rs11935348; rs6841973; rs12506828; rs6829684; rs12498902; rs7661679; rs17011397; rs11097105; rs7676652; rs17011432; rs3762915; rs17011590; rs17011459; rs11947620; rs13110630; rs10006563; rs17011551; rs6811435; rs7663763; rs1318492; rs6531908; rs1903363; rs6842530; rs17011526; rs7663773; rs6813859; rs6817640; rs10019871; rs10030197; rs17408881; rs12500023; rs6831589; rs7682129; rs17011803; rs12511499; rs7697017; rs7661809; rs6813724; rs9994380; rs7690323; rs17011537; rs4371581; rs17011522; rs4693753; rs17451306; rs10006000; rs1460764; rs13112340; rs1460749; rs17011533; rs10003756; rs17011428; rs12511135; rs9996693; rs7698396; rs6845334; rs6824346; rs17011556; rs2904100; rs10213302; rs17409904; rs17011821; rs17011407; rs6826951; rs17011655; rs7667204; rs13115030; rs4299551; rs13140948; rs17011573; rs2035058; rs17011540; rs2009855; rs6847635; rs12500076; rs9994303; rs2589506; rs1436527; rs2589514; rs1436524; rs1469869; rs1436521; rs2589518; rs1541998; rs2282596; rs1946733; rs6822478; rs7435363; rs4403040; rs4693754; rs10004712; rs4235078; rs1898248; rs12502902; rs4546235; rs3775187; rs4352468; rs4334746; rs4613557; rs10028075; rs2118044; rs2282598; rs10031752; rs6531898; rs1436529; rs4501213; rs3775169; rs4377581; rs4482754; rs4364253; rs6821745; rs12647176; rs10024003; rs4407492; rs12639693; rs10001480; rs9307015; rs6856450; rs3775166; rs9884282; rs3775184; rs7692508; rs6810413; rs4133139; rs11929863; rs4487330; rs12642887; rs4693757; rs6854208; rs3775181; rs9995879; rs6848433; rs12650286; rs2282597; rs3775168; rs6815306; rs3775182; rs7692460; rs12640230; rs3775164; rs10212744; rs4530621; rs3775183; rs11097091; rs2575673; rs17011341; rs10009993; rs12644947; rs3775170; rs4414944; rs13103374; rs9307014; rs12647506; rs12502934; rs1469870; rs7670470; rs10003556; rs4446299; rs13112959; rs2575672; rs3775173; rs1436522; rs9884770; rs3775180; rs4351013; rs7692676; rs10033283; rs3775167; rs10212952; rs11097094; rs6531897; rs2043649; rs1010778; rs10020650; rs3775171; rs10011390; rs1002484; rs6531892; rs746438; rs4693136; rs7684198; rs11934691; rs7689936; rs3775176; rs17011324; rs6842186; rs10027764; rs4414943; rs7670786; rs4499692; rs7696878; rs6822410; rs10516763; rs7670681; rs13142206; rs12644938; rs10023731; rs3822036; rs3775175; rs11733961; rs11097092; rs17008675; rs2043650; rs6531893; rs12643642; rs7659520; rs12648064; rs10001162; rs9684602; rs17011322; rs5004884; rs12642872; rs17011339; rs17011349; rs10006261; rs2043648; rs4382028; rs7691896; rs6855234; rs9760017; rs10034271; rs1561154; rs10018678; rs4693756; rs10025882; rs6811151; rs10002407; rs2282599; rs10776485; rs4560400; rs4522858; rs10009942; rs3775185; rs7654005; rs3755971; rs1898249; rs3822037; rs13114632; rs6531891; rs6846365; rs9996208; rs6854511; rs7697197; rs7686599; rs17011355; rs6840318; rs13103861; rs13121113; rs5006575; rs12512583; rs2282595; rs7439672; rs12648171; rs11934127; rs2575674; rs7699978; rs2589515; rs1201; rs2575675; rs1202; rs2589516; rs12512524; rs17011312; rs10032602; rs17011314; rs7660160; rs28760360; rs34414912; rs17450827; rs34255377; rs35547091; rs34168022; rs17011766; rs4458422; rs28536101; rs34262586; rs35517015; rs35294861; rs35501076; rs4608763; rs6849947; rs4129300; rs11435039; rs4269144; rs5860021; rs7436985; rs10534985; rs28896887; rs35116135; rs1115229; rs35217429; rs10671229; rs17416927; rs28839895; rs3527; rs7661648; rs17450910; rs13140380; rs35435792; rs34369854; rs17011858; rs34455560; rs9968336; rs35140130; rs3029315; rs35842829; rs12498558; rs7442188; rs28489900; rs28804774; rs28834688; rs7695670; rs35882077; rs35610513; rs34648043; rs34904465; rs6815085; rs28830848; rs17011643; rs34442411; rs35257599; rs35178184; rs11943866; rs34265383; rs28421956; rs4693769; rs17011682; rs34328856; rs35085432; rs35034762; rs7691277; rs33970548; rs35338513; rs35581530; rs11278816; rs34061649; rs34304791; rs35461035; rs13124817; rs34743167; rs35892134; rs7376405; rs17409269; rs11330422; rs35492319; rs36216983; rs17011720; rs13113317; rs10539886; rs13149041; rs6839310; rs28733919; rs17011696; rs34683010; rs10608638; rs4561895; rs4994993; rs36228436; rs7679167; rs28520822; rs28695505; rs34809402; rs34253891; rs34870954; rs28463620; rs28670086; rs28722990; rs7675381; rs9307017; rs34885616; rs17011700; rs28534721; rs34954949; rs35572072; rs34989577; rs35859687; rs35240319; rs10600798; rs35991788; rs4618275; rs35774265; rs13124872; rs11947890; rs28450091; rs9998205; rs33949420; rs3030118; rs35450214; rs3030160; rs12644976; rs13126246; rs6850992; rs35900214; rs33991102; rs34241060; rs28373627; rs34593390; rs28661214; rs7697335; rs34125064; rs35130751; rs35441446; rs6844636; rs35767206; rs35145865; rs13126021; rs13113315; rs6836359; rs35826931; rs7690940; rs28408117; rs9654155; rs35063332; rs34696102; rs17011690; rs6856862; rs33929180; rs7673423; rs35083678; rs35343868; rs12644859; rs36021595; rs2001612; rs10681488; rs28791572; rs13145464; rs13113328; rs35965801; rs34448816; rs5860022; rs28694187; rs28890938; rs34498673; rs28536743; rs10545105; rs9761579; rs12500128; rs13116387; rs35427609; rs10016000; rs28434311; rs10591715; rs28705770; rs3971920; rs7672563; rs3217717; rs28821771; rs35079757; rs12650508; rs3030142; rs13129988; rs3029313; rs7688495; rs34505400; rs10714569; rs35097345; rs12643272; rs34201683; rs17417827; rs35609863; rs10014678; rs28427030; rs34111505; rs11944190; rs34111165; rs36223042; rs2219590; rs34184989; rs13140549; rs2169232; rs9994347; rs36076697; rs34790740; rs28870188; rs34783569; rs10639041; rs1460768; rs34676161; rs28626971; rs35003006; rs35334656; rs5860019; rs34911547; rs13124881; rs5860023; rs4434210; rs10711609; rs35968542; rs34447604; rs35808523; rs2869434; rs11728235; rs10716571; rs17011853; rs36004445; rs13118244; rs34637756; rs28613556; rs34024985; rs11284646; rs10538760; rs34570949; rs35129937; rs34800738; rs35795436; rs13112890; rs10639042; rs34816270; rs34609132; rs35817774; rs34547847; rs9761874; rs28515691; rs11439209; rs6531899; rs28416998; rs35412018; rs33976873; rs35103650; rs35022866; rs17011806; rs36124809; rs11730779; rs34575399; rs11942108; rs28847910; rs35757767; rs28406787; rs34973055; rs34192441; rs35160765; rs3030124; rs28702698; rs34721708; rs2007976; rs28803851; rs35324025; rs35888867; rs7437697; rs13132706; rs28664010; rs34477595; rs34503531; rs28755839; rs6844802; rs6853290; rs4693762; rs34748597; rs4349565; rs17011815; rs35573944; rs35122643; rs4450887; rs33935168; rs33945648; rs28830922; rs13145461; rs3030114; rs28734891; rs11097095; rs10550573; rs13124525; rs35907363; rs28444287; rs34243707; rs6831733; rs13148508; rs28722583; rs35977040; rs28759971; rs35108904; rs34854999; rs34863847; rs13116803; rs13126094; rs10708095; rs6836163; rs4575960; rs35272630; rs10549069; rs9998829; rs28559713; rs4608764; rs13113779; rs12501090; rs34163860; rs17011764; rs6850605; rs4132491; rs35788198; rs34332756; rs35118208; rs7677406; rs35867435; rs35288754; rs34210154; rs34914334; rs36211477; rs28411373; rs36078401; rs10020888; rs34364808; rs28404815; rs35161743; rs28803213; rs13140707; rs35212998; rs36184857; rs7675359; rs11458660; rs28630852; rs17011897; rs35173052; rs28816476; rs35031715; rs9715449; rs34743978; rs17011767; rs17011845; rs17011819; rs12650517; rs5860024; rs34063796; rs34805580; rs34544666; rs35455450; rs34043435; rs13136303; rs35816063; rs11460057; rs36057902; rs10020889; rs35443953; rs13434575; rs11097096; rs13140740; rs11404211; rs36023771; rs34608518; rs34467283; rs6810953; rs36041399; rs35960605; rs34388593; rs35240246; rs28425193; rs17011774; rs3030110; rs35952969; rs11734792; rs17011872; rs11339874; rs36092105; rs35696959; rs17011708; rs28583812; rs28722082; rs13117193; rs34440566; rs35443845; rs6844573; rs11931070; rs34404446; rs35565125; rs34624037; rs11722341; rs17409562; rs11941923; rs7442324; rs10642552; rs35087395; rs10639063; rs28812808; rs13140361; rs35463589; rs35199525; rs28433471; rs8180149; rs28572764; rs28826941; rs28792132; rs2035055; rs13136895; rs28849082; rs4994992; rs34215628; rs13124639; rs11944647; rs34238796; rs13145457; rs34601352; rs28411372; rs13126019; rs5860025; rs9714693; rs35869982; rs11932859; rs7699144; rs10012013; rs34470194; rs13147005; rs11097097; rs13112497; rs34486987; rs34813710; rs36101511; rs6814123; rs34135924; rs34034936; rs11936320; rs28783973; rs12331772; rs28529458; rs34328097; rs13134099; rs13120126; rs33935094; rs10538012; rs6856365; rs17011354; rs17405567; rs7681267; rs34159031; rs35755826; rs6856155; rs35865395; rs28514916; rs9760243; rs10027225; rs1436523; rs1987599; rs35218486; rs5860017; rs13111648; rs3836594; rs10856856; rs34899473; rs28552906; rs3775186; rs35404583; rs41457050; rs28399149; rs34537730; rs5860013; rs35663996; rs34749448; rs34122764; rs36212057; rs7681951; rs34850141; rs13148731; rs34756998; rs13104555; rs35660849; rs35588497; rs34998174; rs35833770; rs34581941; rs4289439; rs7692668; rs34476895; rs5022021; rs13125713; rs28578870; rs34929575; rs36216172; rs12503688; rs4572869; rs28485608; rs34729900; rs4479697; rs34807837; rs34836858; rs4693755; rs34074833; rs34494584; rs34641637; rs13125729; rs11447293; rs4305506; rs34490730; rs13110593; rs36051698; rs28602213; rs17011338; rs5860016; rs33967580; rs28564356; rs35529605; rs6833404; rs13137708; rs33915987; rs28886577; rs733245; rs35534226; rs35394196; rs34038586; rs34324822; rs11413469; rs34699430; rs34770162; rs28538268; rs28516651; rs34050480; rs35076380; rs11360333; rs34741254; rs5860012; rs10538907; rs13104186; rs4345173; rs3841985; rs34825310; rs5860015; rs35211423; rs7667297; rs13353771; rs6823292; rs6813473; rs6531890; rs36085847; rs34949899; rs3775174; rs3822035; rs28660296; rs10635481; rs35495063; rs34886510; rs13146800; rs28895314; rs35606170; rs28709251; rs13104858; rs6818736; rs28435171; rs35225779; rs28576440; rs34300479; rs33962451; rs4419471; rs36047555; rs35893712; rs35915959; rs6813767; rs28398988; rs993593; rs11464313; rs34890849; rs28538338; rs35985560; rs35971482; rs983362; rs6821840; rs35438921; rs13434461; rs35278948; rs28754957; rs35080222; rs35280239; rs35466444; rs34937342; rs7667730; rs35320793; rs36047328; rs4382027; rs35279016; rs34751931; rs1436525; rs34439623; rs34952784; rs35891526; rs35823399; rs28409011; rs33977029; rs34155854; rs5860011; rs5860014; rs11721577; rs6531896; rs28846216; rs34180438; rs35107154; rs11432370; rs28594219; rs35490865; rs35333179; rs41279295; rs13138031; rs6825701; rs34158309; rs33990825; rs11309220; rs34791873; rs35136227; rs36132996; rs2060588; rs28639372; rs35568742; rs1436526; rs36133086; rs33951909; rs28756326; rs35187473; rs41282389; rs6857877; rs6843159; rs34188118; rs34534392; rs33979648; rs34789840; rs35273363; rs6816545; rs34498081; rs35358194; rs28865277; rs28562760; rs34934309; rs34060265; rs3775172; rs9762665; rs34562438; rs28625279; rs34725089; rs13104097; rs34757256; rs28642002; rs35270911; rs28684379; rs7681273; rs35485855; rs35867054; rs28360921; rs34134501; rs28394598; rs34008671; rs35473638; rs34307500; rs35112097; rs7660151; rs10034578; rs17011284; rs17011286; rs17011297; rs17011308; rs1946734; rs2164535; rs2575676; rs2589509; rs2589523; rs2589525; rs3755970; rs4640664; rs7438872; rs7439032; rs7677101

# Macromolecular_Interacting_Partner_24_General_References:
7826642; 8654373; 10715136; 9739089

# Macromolecular_Interacting_Partner_24_References:
16854387

# Macromolecular_Interacting_Partner_25_ID:
7682

# Macromolecular_Interacting_Partner_25_Name:
Interleukin-2 precursor

# Macromolecular_Interacting_Partner_25_Synonyms:
IL-2; T-cell growth factor; TCGF; Aldesleukin

# Macromolecular_Interacting_Partner_25_Gene_Name:
IL2

# Macromolecular_Interacting_Partner_25_Protein_Sequence:
>Interleukin2 precursor
MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRML
TFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSE
TTFMCEYADETATIVEFLNRWITFCQSIISTLT

# Macromolecular_Interacting_Partner_25_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_25_Molecular_Weight:
17628

# Macromolecular_Interacting_Partner_25_Theoretical_pI:
7.95

# Macromolecular_Interacting_Partner_25_GO_Classification:
>>>
Function:  growth factor activity
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interleukin-2 receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_25_General_Function:
Not Available

# Macromolecular_Interacting_Partner_25_Specific_Function:
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells

# Macromolecular_Interacting_Partner_25_Pathway:
Not Available

# Macromolecular_Interacting_Partner_25_Reaction:
Not Available

# Macromolecular_Interacting_Partner_25_Pfam_Domain_Function:
PF00715:IL2

# Macromolecular_Interacting_Partner_25_Signals:
1-20

# Macromolecular_Interacting_Partner_25_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_25_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_25_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_25_GenBank_ID_Protein:
5729676

# Macromolecular_Interacting_Partner_25_SwissProt_ID:
IL2_HUMAN (P60568)

# Macromolecular_Interacting_Partner_25_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_25_Genecard_id:
IL2

# Macromolecular_Interacting_Partner_25_Geneatlas_id:
IL2

# Macromolecular_Interacting_Partner_25_hgnc_id:
HGNC:6001

# Macromolecular_Interacting_Partner_25_PDB_ID:
1PW6

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_25_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_25_Gene_Sequence:
>462 bp
ATGTACAGGATGCAACTCCTGTCTTGCATTGCACTAAGTCTTGCACTTGTCACAAACAGT
GCACCTACTTCAAGTTCTACAAAGAAAACACAGCTACAACTGGAGCATTTACTGCTGGAT
TTACAGATGATTTTGAATGGAATTAATAATTACAAGAATCCCAAACTCACCAGGATGCTC
ACATTTAAGTTTTACATGCCCAAGAAGGCCACAGAACTGAAACATCTTCAGTGTCTAGAA
GAAGAACTCAAACCTCTGGAGGAAGTGCTAAATTTAGCTCAAAGCAAAAACTTTCACTTA
AGACCCAGGGACTTAATCAGCAATATCAACGTAATAGTTCTGGAACTAAAGGGATCTGAA
ACAACATTCATGTGTGAATATGCTGATGAGACAGCAACCATTGTAGAATTTCTGAACAGA
TGGATTACCTTTTGTCAAAGCATCATCTCAACACTGACTTGA

# Macromolecular_Interacting_Partner_25_GenBank_ID_Gene:
J00264

# Macromolecular_Interacting_Partner_25_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_25_Locus:
4q26-q27

# Macromolecular_Interacting_Partner_25_SNPs:
rs3087209; rs2069763; rs2069778; rs2069769; rs2069764; rs2069779; rs1479920; rs2069768; rs2069765; rs1479921; rs2069771; rs2069772; rs2069773; rs2069770; rs2069777; rs2069776; rs2069762; rs2067006; rs2069774; rs1479922; rs11575812; rs10019970; rs11575810; rs1051753; rs34762647; rs35084452; rs2069767; rs34501152; rs11575807; rs41304870; rs33988980; rs34863848; rs34419809; rs2448491; rs2069766; rs11575808; rs2069760; rs2069775; rs11575811; rs36215455; rs2069780; rs36215457; rs36215454; rs11575813; rs2069761; rs35007569; rs36215456; rs35104399; rs10027390; rs11932411; rs13435525; rs1479923; rs1479924; rs2219865; rs3136534; rs4833248

# Macromolecular_Interacting_Partner_25_General_References:
6330695; 6403867; 6312994; 6306584; 6608729; 6324170; 7722480; 8824916; 3264184; 3491296; 6333684; 2793860; 3500515; 1631562; 1510960; 7529123

# Macromolecular_Interacting_Partner_25_References:
12875900; 14686796; 16318858; 16725211

# Macromolecular_Interacting_Partner_26_ID:
7351

# Macromolecular_Interacting_Partner_26_Name:
Histone H4

# Macromolecular_Interacting_Partner_26_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_26_Gene_Name:
HIST1H4A

# Macromolecular_Interacting_Partner_26_Protein_Sequence:
>Histone H4
MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLK
VFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

# Macromolecular_Interacting_Partner_26_Number_of_Residues:
103

# Macromolecular_Interacting_Partner_26_Molecular_Weight:
11368

# Macromolecular_Interacting_Partner_26_Theoretical_pI:
11.91

# Macromolecular_Interacting_Partner_26_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  chromosome organization and biogenesis
Process:  chromosome organization and biogenesis (sensu Eukaryota)
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  protein complex assembly
Process:  nucleosome assembly
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus
Component:  protein complex
Component:  nucleosome

# Macromolecular_Interacting_Partner_26_General_Function:
Chromatin structure and dynamics 

# Macromolecular_Interacting_Partner_26_Specific_Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodelling

# Macromolecular_Interacting_Partner_26_Pathway:
Not Available

# Macromolecular_Interacting_Partner_26_Reaction:
Not Available

# Macromolecular_Interacting_Partner_26_Pfam_Domain_Function:
PF00125:Histone

# Macromolecular_Interacting_Partner_26_Signals:
None

# Macromolecular_Interacting_Partner_26_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_26_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_26_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_26_GenBank_ID_Protein:
32097

# Macromolecular_Interacting_Partner_26_SwissProt_ID:
H4_HUMAN (P62805)

# Macromolecular_Interacting_Partner_26_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_26_Genecard_id:
HIST1H4A

# Macromolecular_Interacting_Partner_26_Geneatlas_id:
HIST1H4A

# Macromolecular_Interacting_Partner_26_hgnc_id:
HGNC:4781

# Macromolecular_Interacting_Partner_26_PDB_ID:
1EQZ

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_26_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_26_Gene_Sequence:
>312 bp
ATGTCCGGCTGTGGAAAGGGCGGAAAGGGCTTAGGCAAAGGTGGCGCTAAGCGCCACCGC
AAGGTCTTGAGAGACAACATTCAGGGCATCACCAAGCCTGCCATTCGGCGTNTAGCTCGG
CGTGGCGGCGTTAAGCGGATCTCTGGCCTCATTTACGAGGAGACCCGCGGTGTGCTGAAA
GTGTTCTTGGAGAATGTGATTCGGGACGCAGTCACCTACACCGAGCACGCCAAGCGCAAG
ACCGTCACAGCCATGGATGTGGTGTACGCGCTCAAGCGNCAGGGGAGNACCCTCTACGGC
TTCGGAGGCTAG

# Macromolecular_Interacting_Partner_26_GenBank_ID_Gene:
X00038

# Macromolecular_Interacting_Partner_26_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_26_Locus:
6p21.3

# Macromolecular_Interacting_Partner_26_SNPs:
Not Available

# Macromolecular_Interacting_Partner_26_General_References:
6314274; 3035717; 1916825; 7626218; 9031620; 9439656; 9119399; 12408966; 14574404; 3340182; 2474456

# Macromolecular_Interacting_Partner_26_References:
15210580; 15261456; 16904069

# Macromolecular_Interacting_Partner_27_ID:
7113

# Macromolecular_Interacting_Partner_27_Name:
Cytochrome c

# Macromolecular_Interacting_Partner_27_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_27_Gene_Name:
CYCS

# Macromolecular_Interacting_Partner_27_Protein_Sequence:
>Cytochrome c
MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSYTAANKNKGIIW
GEDTLMEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNE

# Macromolecular_Interacting_Partner_27_Number_of_Residues:
105

# Macromolecular_Interacting_Partner_27_Molecular_Weight:
11749

# Macromolecular_Interacting_Partner_27_Theoretical_pI:
10.16

# Macromolecular_Interacting_Partner_27_GO_Classification:
>>>
Function:  binding
Function:  tetrapyrrole binding
Function:  heme binding
Function:  transporter activity
Function:  electron transporter activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_27_General_Function:
Energy production and conversion 

# Macromolecular_Interacting_Partner_27_Specific_Function:
Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases

# Macromolecular_Interacting_Partner_27_Pathway:
Not Available

# Macromolecular_Interacting_Partner_27_Reaction:
Not Available

# Macromolecular_Interacting_Partner_27_Pfam_Domain_Function:
PF00034:Cytochrom_C

# Macromolecular_Interacting_Partner_27_Signals:
None

# Macromolecular_Interacting_Partner_27_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_27_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_27_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_27_GenBank_ID_Protein:
181242

# Macromolecular_Interacting_Partner_27_SwissProt_ID:
CYC_HUMAN (P99999)

# Macromolecular_Interacting_Partner_27_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_27_Genecard_id:
CYCS

# Macromolecular_Interacting_Partner_27_Geneatlas_id:
CYCS

# Macromolecular_Interacting_Partner_27_hgnc_id:
HGNC:19986

# Macromolecular_Interacting_Partner_27_PDB_ID:
1J3S

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_27_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Macromolecular_Interacting_Partner_27_Gene_Sequence:
>318 bp
ATGGGTGATGTTGAGAAAGGCAAGAAGATTTTTATTATGAAGTGTTCCCAGTGCCACACC
GTTGAAAAGGGAGGCAAGCACAAGACTGGGCCAAATCTCCATGGTCTCTTTGGGCGGAAG
ACAGGTCAGGCCCCTGGATACTCTTACACAGCCGCCAATAAGAACAAAGGCATCATCTGG
GGAGAGGATACACTGATGGAGTATTTGGAGAATCCCAAGAAGTACATCCCTGGAACAAAA
ATGATCTTTGTCGGCATTAAGAAGAAGGAAGAAAGGGCAGACTTAATAGCTTATCTCAAA
AAAGCTACTAATGAGTAA

# Macromolecular_Interacting_Partner_27_GenBank_ID_Gene:
M22877

# Macromolecular_Interacting_Partner_27_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_27_Locus:
7p15.2

# Macromolecular_Interacting_Partner_27_SNPs:
rs11769363; rs7810784; rs1861525; rs12700584; rs10215217; rs4719799; rs12700583; rs12700582; rs3846998; rs2107123; rs11548785; rs11548815; rs11548798; rs11548802; rs11548799; rs11548820; rs11548772; rs11548783; rs11548796; rs11548816; rs11548795; rs3211452; rs11548791; rs11548818; rs11548805; rs3211451; rs11548807; rs11548778; rs17851278; rs11548812; rs11548776; rs11548797; rs11548779; rs11548806; rs11548774; rs11548777; rs11427893; rs1137513; rs3173604; rs11548775; rs1060389; rs1137505; rs1137510; rs11548804; rs1801082; rs1060388; rs1137506; rs11548773; rs41275976; rs1137512; rs1137508; rs13310377; rs13310456; rs34522469; rs35325343; rs1137507; rs11548787; rs1137511; rs10230102; rs11548792; rs28376346; rs1137509; rs36061386; rs6967260; rs3040291; rs16873757; rs5882962; rs34102874; rs34500218; rs10238032; rs17150957; rs10278815; rs10279024; rs10951046; rs11489282; rs12700580; rs2107121; rs2107122; rs2391087; rs2717885; rs2717886

# Macromolecular_Interacting_Partner_27_General_References:
2849112; 12853948; 9515723

# Macromolecular_Interacting_Partner_27_References:
14559818; 15177505; 15781658

# Macromolecular_Interacting_Partner_28_ID:
7694

# Macromolecular_Interacting_Partner_28_Name:
Peroxisome proliferator-activated receptor alpha

# Macromolecular_Interacting_Partner_28_Synonyms:
PPAR-alpha

# Macromolecular_Interacting_Partner_28_Gene_Name:
PPARA

# Macromolecular_Interacting_Partner_28_Protein_Sequence:
>Peroxisome proliferatoractivated receptor alpha
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY

# Macromolecular_Interacting_Partner_28_Number_of_Residues:
468

# Macromolecular_Interacting_Partner_28_Molecular_Weight:
52226

# Macromolecular_Interacting_Partner_28_Theoretical_pI:
6.20

# Macromolecular_Interacting_Partner_28_GO_Classification:
>>>
Function:  steroid hormone receptor activity
Function:  transcription factor activity
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_28_General_Function:
Not Available

# Macromolecular_Interacting_Partner_28_Specific_Function:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids

# Macromolecular_Interacting_Partner_28_Pathway:
Not Available

# Macromolecular_Interacting_Partner_28_Reaction:
Not Available

# Macromolecular_Interacting_Partner_28_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_28_Signals:
None

# Macromolecular_Interacting_Partner_28_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_28_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_28_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_28_GenBank_ID_Protein:
307341

# Macromolecular_Interacting_Partner_28_SwissProt_ID:
PPARA_HUMAN (Q07869)

# Macromolecular_Interacting_Partner_28_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_28_Genecard_id:
PPARA

# Macromolecular_Interacting_Partner_28_Geneatlas_id:
PPARA

# Macromolecular_Interacting_Partner_28_hgnc_id:
HGNC:9232

# Macromolecular_Interacting_Partner_28_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_28_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_28_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_28_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_28_Gene_Sequence:
>1407 bp
ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAG
AGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGGAAACATCCAAGAGATTTCGCAATCC
ATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT
CCTGGCTCAGATGGCTCGGTCATCACGGACACGCTTTCACCAGCTTCGAGCCCCTCCTCG
GTGACTTATCCTGTGGTCCCCGGCAGCGTGGACGAGTCTCCCAGTGGAGCATTGAACATC
GAATGTAGAATCTGCGGGGACAAGGCCTCAGGCTATCATTACGGAGTCCACGCGTGTGAA
GGCTGCAAGGGCTTCTTTCGGCGAACGATTCGACTCAAGCTGGTGTATGACAAGTGCGAC
CGCAGCTGCAAGATCCAGAAAAAGAACAGAAACAAATGCCAGTATTGTCGATTTCACAAG
TGCCTTTCTGTCGGGATGTCACACAACGCGATTCGTTTTGGACGAATGCCAAGATCTGAG
AAAGCAAAACTGAAAGCAGAAATTCTTACCTGTGAACATGACATAGAAGATTCTGAAACT
GCAGATCTCAAATCTCTGGCCAAGAGAATCTACGAGGCCTACTTGAAGAACTTCAACATG
AACAAGGTCAAAGCCCGGGTCATCCTCTCAGGAAAGGCCAGTAACAATCCACCTTTTGTC
ATACATGATATGGAGACACTGTGTATGGCTGAGAAGACGCTGGTGGCCAAGCTGGTGGCC
AATGGCATCCAGAACAAGGAGGTGGAGGTCCGCATCTTTCACTGCTGCCAGTGCACGTCA
GTGGAGACCGTCACGGAGCTCACGGAATTCGCCAAGGCCATCCCAGCGTTCGCAAACTTG
GACCTGAACGATCAAGTGACATTGCTAAAATACGGAGTTTATGAGGCCATATTCGCCATG
CTGTCTTCTGTGATGAACAAAGACGGGATGCTGGTAGCGTATGGAAATGGGTTTATAACT
CGTGAATTCCTAAAAAGCCTAAGGAAACCGTTCTGTGATATCATGGAACCCAAGTTTGAT
TTTGCCATGAAGTTCAATGCACTGGAACTGGATGACAGTGATATCTCCCTTTTTGTGGCT
GCTATCATTTGCTGTGGAGATCGTCCTGGCCTTCTAAACGTAGGACACATTGAAAAAATG
CAGGAGGGTATTGTACATGTGCTCAGACTCCACCTGCAGAGCAACCACCCGGACGATATC
TTTCTCTTCCCAAAACTTCTTCAAAAAATGGCAGACCTCCGGCAGCTGGTGACGGAGCAT
GCGCAGCTGGTGCAGATCATCAAGAAGACGGAGTCGGATGCTGCGCTGCACCCGCTACTG
CAGGAGATCTACAGGGACATGTACTGA

# Macromolecular_Interacting_Partner_28_GenBank_ID_Gene:
L02932

# Macromolecular_Interacting_Partner_28_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_28_Locus:
22q12-q13.1|22q13.31

# Macromolecular_Interacting_Partner_28_SNPs:
rs1800206; rs1800234; rs1800204; rs1800235; rs4253773; rs135547; rs129600; rs4253681; rs4253652; rs135552; rs135539; rs135542; rs4253655; rs12330015; rs9627046; rs135538; rs4253663; rs7364220; rs4253620; rs4253698; rs4253781; rs9626729; rs4253758; rs4253699; rs4253630; rs4253682; rs4253703; rs1555208; rs4253701; rs4253622; rs4253704; rs135549; rs4253665; rs4253686; rs4253792; rs6008259; rs4253702; rs4253669; rs135550; rs135543; rs4253621; rs4253788; rs4253678; rs4253695; rs4253791; rs5769177; rs4253674; rs4253671; rs4253641; rs4253624; rs5766696; rs4253639; rs4253618; rs7286168; rs4253786; rs4253784; rs4253651; rs4253757; rs4253800; rs8138102; rs4253635; rs4253670; rs4253789; rs11704856; rs4253660; rs4253645; rs9626736; rs4253797; rs135540; rs4253638; rs4253694; rs8135690; rs4253633; rs4253627; rs4253642; rs4253696; rs4253656; rs4253706; rs4253659; rs4253672; rs4253691; rs4253667; rs9306498; rs5766698; rs4253688; rs4253623; rs4253634; rs4253801; rs1055659; rs135548; rs4253687; rs4253707; rs4253646; rs6008970; rs4253664; rs4253643; rs4253700; rs4253668; rs135555; rs4253685; rs4253640; rs6008976; rs7287085; rs4253705; rs3892755; rs4253661; rs4253626; rs4253637; rs4253658; rs4253629; rs4253782; rs4253647; rs7289836; rs4253679; rs135551; rs4253793; rs4253617; rs4253692; rs4253631; rs4253644; rs4253625; rs9306499; rs4253790; rs4253787; rs4253683; rs4253619; rs4253662; rs4253657; rs5769178; rs4253756; rs4253684; rs4253636; rs135554; rs4253785; rs4253628; rs9626737; rs4253780; rs4253654; rs4253677; rs761543; rs4253783; rs4253648; rs11704979; rs4253680; rs4253616; rs9626814; rs4253653; rs4253693; rs4253673; rs4253632; rs4253650; rs4253689; rs11913649; rs4253666; rs4823902; rs11704508; rs5769243; rs10427717; rs8135547; rs9680739; rs8139731; rs17661656; rs3747246; rs41367645; rs17661718; rs9306500; rs5766804; rs135553; rs41388244; rs9615264; rs16994933; rs41427746; rs16994915; rs6007981; rs17241878; rs10154348; rs12162684; rs11705154; rs11703495; rs135541; rs12160659; rs7287027; rs4823586; rs6009111; rs41378347; rs12169296; rs135545; rs1134224; rs10775794; rs11703746; rs135536; rs9680676; rs12169290; rs9627268; rs5769366; rs17241885; rs7288994; rs9627100; rs7289495; rs1055657; rs6009081; rs135546; rs1800246; rs5767743; rs4253762; rs4253778; rs4253690; rs4823613; rs4253769; rs4253751; rs6008197; rs6519979; rs4253761; rs4253747; rs4253730; rs4253775; rs4253713; rs4253719; rs4253750; rs4253764; rs4253765; rs4253776; rs4253729; rs4253709; rs4253712; rs4253760; rs4253728; rs11090819; rs4253737; rs4253770; rs4253777; rs2336904; rs4253711; rs4253754; rs4253798; rs4253748; rs4253727; rs4253723; rs4253710; rs4253714; rs6008160; rs4253708; rs4253718; rs4253774; rs4253722; rs4253767; rs4253732; rs5766741; rs4253726; rs4253799; rs5767700; rs7364297; rs4253736; rs4253794; rs4253752; rs4253731; rs4253766; rs4253721; rs4253717; rs4253742; rs4253744; rs4253697; rs4253771; rs4253746; rs4253725; rs4253739; rs4253720; rs4253738; rs4253755; rs1800245; rs4253795; rs4253716; rs4253735; rs4253734; rs5766743; rs4253779; rs4253741; rs4253753; rs6007662; rs4253768; rs4253743; rs4253745; rs4253772; rs4253763; rs4253724; rs4253759; rs4253733; rs4253715; rs8139794; rs4253740; rs4253749; rs8139663; rs41397552; rs11090791; rs11702902; rs11090817; rs6008123; rs7291727; rs5769175; rs5767636; rs9615238; rs5767560; rs5766734; rs6008126; rs5767633; rs11090818; rs8140236; rs12170204; rs9626730; rs11705483; rs11913971; rs7292459; rs5767634; rs4823477; rs6413511; rs1800243; rs1800242; rs9615759; rs1042311; rs5767686; rs1800236; rs12167302; rs9615163; rs41418950; rs34666721; rs5769287; rs35328780; rs7292112; rs11383159; rs7364140; rs5769365; rs34148860; rs5845740; rs35404482; rs35249750; rs41403648; rs35988564; rs6009112; rs5845739; rs36096470; rs41532849; rs881740; rs9615524; rs7286871; rs12484245; rs13053358; rs11538240; rs35966870; rs34896841; rs35838035; rs10643430; rs13053293; rs5767779; rs12171095; rs41479847; rs28772875; rs6009058; rs4592961; rs9627007; rs34109484; rs12159525; rs12170381; rs5845741; rs135544; rs41406451; rs35398060; rs28369325; rs5769129; rs12160049; rs34857047; rs12159225; rs6008042; rs7364165; rs10561065; rs7289761; rs5769184; rs9626764; rs12159821; rs5766682; rs41362646; rs41465647; rs3840962; rs5769088; rs41371446; rs2238833; rs4823487; rs9626756; rs7290774; rs41368348; rs5769276; rs34001104; rs35552991; rs28716636; rs13055301; rs5767424; rs12167354; rs1055658; rs41477146; rs5769364; rs36096495; rs5769356; rs35281820; rs35038216; rs41371949; rs5769142; rs11703765; rs35808855; rs6009014; rs41489145; rs9626751; rs135537; rs41355347; rs34437230; rs9615534; rs6007965; rs12159097; rs9615784; rs11344804; rs5769219; rs9615523; rs16994976; rs9626716; rs28895660; rs41329344; rs35345592; rs41489148; rs1800244; rs13054427; rs11912612; rs11703766; rs36124248; rs12166902; rs6008974; rs13055320; rs5769112; rs41332048; rs12169623; rs5769206; rs36074474; rs35436527; rs13056945; rs8139926; rs9627217; rs6008089; rs10570542; rs34977841; rs11325484; rs35637220; rs9615694; rs17847852; rs4365564; rs5767667; rs8135879; rs12166737; rs5767617; rs5766714; rs9626745; rs2336905; rs6008193; rs9615695; rs7290878; rs1973929; rs28875881; rs41526048; rs35528985; rs12168403; rs34108706; rs34716781; rs9626811; rs41461946; rs12168939; rs6008129; rs34902389; rs12166868; rs10563623; rs10427969; rs8141725; rs4365565; rs5767650; rs34142992; rs9627047; rs7290473; rs5767708; rs6008149; rs34052175; rs11703314; rs6008161; rs10593071; rs35418581; rs11445888; rs35658961; rs34873839; rs10658167; rs41497148; rs35027666; rs6008116; rs34774436; rs11270575; rs34036883; rs35700219; rs6008093; rs6007639; rs13057868; rs28669215; rs11332243; rs41343752; rs28508200; rs2283673; rs5767618; rs28786744; rs10591809; rs12170430; rs12168830; rs12167549; rs34858419; rs13058348; rs8141442; rs6008191; rs6008096; rs5767763; rs35145000; rs28584795; rs6007673; rs7286742; rs12168937; rs28828403; rs35615646; rs34406573; rs13058552; rs6008130; rs12166556; rs13056831; rs9626742; rs34363509; rs9615487; rs5767320; rs34775146; rs9626709; rs12157295; rs10154668; rs1053332; rs11705226; rs12106599; rs12159251; rs135556; rs135557; rs135559; rs135560; rs135561; rs135562; rs14842; rs14843; rs16995065; rs16995067; rs16995069; rs5767842; rs6008923; rs717926; rs7284616; rs7289611; rs7291028; rs9626816; rs9626823; rs9627278; rs9627280; rs9627281; rs9627287

# Macromolecular_Interacting_Partner_28_General_References:
7684926; 7981125; 8993548; 10591208; 9238002; 10681503

# Macromolecular_Interacting_Partner_28_References:
12949056; 15068815; 16226051

# Macromolecular_Interacting_Partner_29_ID:
5240

# Macromolecular_Interacting_Partner_29_Name:
Histone acetyltransferase p300

# Macromolecular_Interacting_Partner_29_Synonyms:
E1A-associated protein p300

# Macromolecular_Interacting_Partner_29_Gene_Name:
EP300

# Macromolecular_Interacting_Partner_29_Protein_Sequence:
>Histone acetyltransferase p300
MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGD
INQLQTSLGMVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQVMASQAQQSSPGLGLINS
MVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGTNAGMNPGMLAA
GNGQGIMPNQVMNGSIGAGRGRQDMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQ
PLKMGMMNNPNPYGSPYTQNPGQQIGASGLGLQIQTKTVLSNNLSPFAMDKKAVPGGGMP
NMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGE
VRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNA
GDKRNQQPILTGAPVGLGNPSSLGVGQQSAPNLSTVSQIDPSSIERAYAALGLPYQVNQM
PTQPQVQAKNQQNQQPGQSPQGMRPMSNMSASPMGVNGGVGVQTPSLLSDSMLHSAINSQ
NPMMSENASVPSLGPMPTAAQPSTTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAAL
KDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRRTRLQKQNMLPN
AAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPNQMMPRITPQSGLNQFGQMSM
AQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTNI
PLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTP
TPHHTPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPS
LPAAPSADQPQQQPRSQQSTAASVPTPNAPLLPPQPATPLSQPAVSIEGQVSNPPSTSST
EVNSQAIAEKQPSQEVKMEAKMEVDQPEPADTQPEDISESKVEDCKMESTETEERSTELK
TEIKEEEDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVD
PQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYK
YCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHF
CEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVL
HHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGE
VTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQE
YGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPP
SEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKE
LPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKNNKKTSKNK
SSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIP
CDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVETR
WHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQ
SLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENK
CPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTG
QQPTTPQTPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPG
PPPTAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPPMTPMAPMGMNPPPMTRGPSGHL
EPGMGPTGMQQQPPWSQGGLPQPQQLQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGISP
LKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPI
PGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPPMGG
MSPQAQQMNMNHNTMPSQFRDILRRQQMMQQQQQQGAGPGIGPGMANHNQFQQPQGVGYP
PQPQQRMQHHMQQMQQGNMGQIGQLPQALGAEAGASLQAYQQRLLQQQMGSPVQPNPMSP
QQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHV
SPQTSSPHPGLVAAQANPMEQGHFASPDQNSMLSQLASNPGMANLHGASATDLGLSTDNS
DLNSNLSQSTLDIH

# Macromolecular_Interacting_Partner_29_Number_of_Residues:
2414

# Macromolecular_Interacting_Partner_29_Molecular_Weight:
264147

# Macromolecular_Interacting_Partner_29_Theoretical_pI:
8.56

# Macromolecular_Interacting_Partner_29_GO_Classification:
>>>
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  transcription coactivator activity
Function:  binding
Function:  protein binding
Function:  transcription factor binding
Function:  transcription cofactor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_29_General_Function:
Not Available

# Macromolecular_Interacting_Partner_29_Specific_Function:
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes

# Macromolecular_Interacting_Partner_29_Pathway:
Not Available

# Macromolecular_Interacting_Partner_29_Reaction:
acetyl-CoA + histone = CoA + acetylhistone

# Macromolecular_Interacting_Partner_29_Pfam_Domain_Function:
PF00439:Bromodomain;
PF09030:Creb_binding;
PF06001:DUF902;
PF06010:DUF906;
PF02172:KIX;
PF02135:zf-TAZ;
PF00569:ZZ

# Macromolecular_Interacting_Partner_29_Signals:
None

# Macromolecular_Interacting_Partner_29_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_29_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_29_EC_Link:
EC 2.3.1.48

# Macromolecular_Interacting_Partner_29_GenBank_ID_Protein:
495301

# Macromolecular_Interacting_Partner_29_SwissProt_ID:
EP300_HUMAN (Q09472)

# Macromolecular_Interacting_Partner_29_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_29_Genecard_id:
EP300

# Macromolecular_Interacting_Partner_29_Geneatlas_id:
EP300

# Macromolecular_Interacting_Partner_29_hgnc_id:
HGNC:3373

# Macromolecular_Interacting_Partner_29_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_29_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_29_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_29_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_29_Gene_Sequence:
>7245 bp
ATGGCCGAGAATGTGGTGGAACCGGGGCCGCCTTCAGCCAAGCGGCCTAAACTCTCATCT
CCGGCCCTCTCGGCGTCCGCCAGCGATGGCACAGATTTTGGCTCTCTATTTGACTTGGAG
CACGACTTACCAGATGAATTAATCAACTCTACAGAATTGGGACTAACCAATGGTGGTGAT
ATTAATCAGCTTCAGACAAGTCTTGGCATGGTACAAGATGCAGCTTCTAAACATAAACAG
CTGTCAGAATTGCTGCGATCTGGTAGTTCCCCTAACCTCAATATGGGAGTTGGTGGCCCA
GGTCAAGTCATGGCCAGCCAGGCCCAACAGAGCAGTCCTGGATTAGGTTTGATAAATAGC
ATGGTCAAAAGCCCAATGACACAGGCAGGCTTGACTTCTCCCAACATGGGGATGGGCACT
AGTGGACCAAATCAGGGTCCTACGCAGTCAACAGGTATGATGAACAGTCCAGTAAATCAG
CCTGCCATGGGAATGAACACAGGGACGAATGCGGGCATGAATCCTGGAATGTTGGCTGCA
GGCAATGGACAAGGGATAATGCCTAATCAAGTCATGAACGGTTCAATTGGAGCAGGCCGA
GGGCGACAGGATATGCAGTACCCAAACCCAGGCATGGGAAGTGCTGGCAACTTACTGACT
GAGCCTCTTCAGCAGGGCTCTCCCCAGATGGGAGGACAAACAGGATTGAGAGGCCCCCAG
CCTCTTAAGATGGGAATGATGAACAACCCCAATCCTTATGGTTCACCATATACTCAGAAT
CCTGGACAGCAGATTGGAGCCAGTGGCCTTGGTCTCCAGATTCAGACAAAAACTGTACTA
TCAAATAACTTATCTCCATTTGCTATGGACAAAAAGGCAGTTCCTGGTGGAGGAATGCCC
AACATGGGTCAACAGCCAGCCCCGCAGGTCCAGCAGCCAGGTCTGGTGACTCCAGTTGCC
CAAGGGATGGGTTCTGGAGCACATACAGCTGATCCAGAGAAGCGCAAGCTCATCCAGCAG
CAGCTTGTTCTCCTTTTGCATGCTCACAAGTGCCAGCGCCGGGAACAGGCCAATGGGGAA
GTGAGGCAGTGCAACCTTCCCCACTGTCGCACAATGAAGAATGTCCTAAACCACATGACA
CACTGCCAGTCAGGCAAGTCTTGCCAAGTGGCACACTGTGCATCTTCTCGACAAATCATT
TCACACTGGAAGAATTGTACAAGACATGATTGTCCTGTGTGTCTCCCCCTCAAAAATGCT
GGTGATAAGAGAAATCAACAGCCAATTTTGACTGGAGCACCCGTTGGACTTGGAAATCCT
AGCTCTCTAGGGGTGGGTCAACAGTCTGCCCCCAACCTAAGCACTGTTAGTCAGATTGAT
CCCAGCTCCATAGAAAGAGCCTATGCAGCTCTTGGACTACCCTATCAAGTAAATCAGATG
CCGACACAACCCCAGGTGCAAGCAAAGAACCAGCAGAATCAGCAGCCTGGGCAGTCTCCC
CAAGGCATGCGGCCCATGAGCAACATGAGTGCTAGTCCTATGGGAGTAAATGGAGGTGTA
GGAGTTCAAACGCCGAGTCTTCTTTCTGACTCAATGTTGCATTCAGCCATAAATTCTCAA
AACCCAATGATGAGTGAAAATGCCAGTGTGCCCTCCCTGGGTCCTATGCCAACAGCAGCT
CAACCATCCACTACTGGAATTCGGAAACAGTGGCACGAAGATATTACTCAGGATCTTCGA
AATCATCTTGTTCACAAACTCGTCCAAGCCATATTTCCTACGCCGGATCCTGCTGCTTTA
AAAGACAGACGGATGGAAAACCTAGTTGCATATGCTCGGAAAGTTGAAGGGGACATGTAT
GAATCTGCAAACAATCGAGCGGAATACTACCACCTTCTAGCTGAGAAAATCTATAAGATC
CAGAAAGAACTAGAAGAAAAACGAAGGACCAGACTACAGAAGCAGAACATGCTACCAAAT
GCTGCAGGCATGGTTCCAGTTTCCATGAATCCAGGGCCTAACATGGGACAGCCGCAACCA
GGAATGACTTCTAATGGCCCTCTACCTGACCCAAGTATGATCCGTGGCAGTGTGCCAAAC
CAGATGATGCCTCGAATAACTCCACAATCTGGTTTGAATCAATTTGGCCAGATGAGCATG
GCCCAGCCCCCTATTGTACCCCGGCAAACCCCTCCTCTTCAGCACCATGGACAGTTGGCT
CAACCTGGAGCTCTCAACCCGCCTATGGGCTATGGGCCTCGTATGCAACAGCCTTCCAAC
CAGGGCCAGTTCCTTCCTCAGACTCAGTTCCCATCACAGGGAATGAATGTAACAAATATC
CCTTTGGCTCCGTCCAGCGGTCAAGCTCCAGTGTCTCAAGCACAAATGTCTAGTTCTTCC
TGCCCGGTGAACTCTCCTATAATGCCTCCAGGGTCTCAGGGGAGCCACATTCACTGTCCC
CAGCTTCCTCAACCAGCTCTTCATCAGAATTCACCCTCGCCTGTACCTAGTCGTACCCCC
ACCCCTCACCATACTCCCCCAAGCATAGGGGCTCAGCAGCCACCAGCAACAACAATTCCA
GCCCCTGTTCCTACACCACCAGCCATGCCACCTGGGCCACAGTCCCAGGCTCTACATCCC
CCTCCAAGGCAGACACCTACACCACCAACAACACAACTTCCCCAACAAGTGCAGCCTTCA
CTTCCTGCTGCACCTTCTGCTGACCAGCCCCAGCAGCAGCCTCGCTCACAGCAGAGCACA
GCAGCGTCTGTTCCTACCCCAAACGCACCGCTGCTTCCTCCGCAGCCTGCAACTCCACTT
TCCCAGCCAGCTGTAAGCATTGAAGGACAGGTATCAAATCCTCCATCTACTAGTAGCACA
GAAGTGAATTCTCAGGCCATTGCTGAGAAGCAGCCTTCCCAGGAAGTGAAGATGGAGGCC
AAAATGGAAGTGGATCAACCAGAACCAGCAGATACGCAGCCGGAGGATATTTCAGAGTCT
AAAGTGGAAGACTGTAAAATGGAATCTACCGAAACAGAAGAGAGAAGCACTGAGTTAAAA
ACTGAAATAAAAGAGGAGGAAGACCAGCCAAGTACTTCAGCTACCCAGTCATCTCCGGCT
CCAGGACAGTCAAAGAAAAAGATTTTCAAACCAGAAGAACTACGACAGGCACTGATGCCA
ACATTGGAGGCACTTTACCGTCAGGATCCAGAATCCCTTCCCTTTCGTCAACCTGTGGAC
CCTCAGCTTTTAGGAATCCCTGATTACTTTGATATTGTGAAGAGCCCCATGGATCTTTCT
ACCATTAAGAGGAAGTTAGACACTGGACAGTATCAGGAGCCCTGGCAGTATGTCGATGAT
ATTTGGCTTATGTTCAATAATGCCTGGTTATATAACCGGAAAACATCACGGGTATACAAA
TACTGCTCCAAGCTCTCTGAGGTCTTTGAACAAGAAATTGACCCAGTGATGCAAAGCCTT
GGATACTGTTGTGGCAGAAAGTTGGAGTTCTCTCCACAGACACTGTGTTGCTACGGCAAA
CAGTTGTGCACAATACCTCGTGATGCCACTTATTACAGTTACCAGAACAGGTATCATTTC
TGTGAGAAGTGTTTCAATGAGATCCAAGGGGAGAGCGTTTCTTTGGGGGATGACCCTTCC
CAGCCTCAAACTACAATAAATAAAGAACAATTTTCCAAGAGAAAAAATGACACACTGGAT
CCTGAACTGTTTGTTGAATGTACAGAGTGCGGAAGAAAGATGCATCAGATCTGTGTCCTT
CACCATGAGATCATCTGGCCTGCTGGATTCGTCTGTGATGGCTGTTTAAAGAAAAGTGCA
CGAACTAGGAAAGAAAATAAGTTTTCTGCTAAAAGGTTGCCATCTACCAGACTTGGCACC
TTTCTAGAGAATCGTGTGAATGACTTTCTGAGGCGACAGAATCACCCTGAGTCAGGAGAG
GTCACTGTTAGAGTAGTTCATGCTTCTGACAAAACCGTGGAAGTAAAACCAGGCATGAAA
GCAAGGTTTGTGGACAGTGGAGAGATGGCAGAATCCTTTCCATACCGAACCAAAGCCCTC
TTTGCCTTTGAAGAAATTGATGGTGTTGACCTGTGCTTCTTTGGCATGCATGTTCAAGAG
TATGGCTCTGACTGCCCTCCACCCAACCAGAGGAGAGTATACATATCTTACCTCGATAGT
GTTCATTTCTTCCGTCCTAAATGCTTGAGGACTGCAGTCTATCATGAAATCCTAATTGGA
TATTTAGAATATGTCAAGAAATTAGGTTACACAACAGGGCATATTTGGGCATGTCCACCA
AGTGAGGGAGATGATTATATCTTCCATTGCCATCCTCCTGACCAGAAGATACCCAAGCCC
AAGCGACTGCAGGAATGGTACAAAAAAATGCTTGACAAGGCTGTATCAGAGCGTATTGTC
CATGACTACAAGGATATTTTTAAACAAGCTACTGAAGATAGATTAACAAGTGCAAAGGAA
TTGCCTTATTTCGAGGGTGATTTCTGGCCCAATGTTCTGGAAGAAAGCATTAAGGAACTG
GAACAGGAGGAAGAAGAGAGAAAACGAGAGGAAAACACCAGCAATGAAAGCACAGATGTG
ACCAAGGGAGACAGCAAAAATGCTAAAAAGAAGAATAATAAGAAAACCAGCAAAAATAAG
AGCAGCCTGAGTAGGGGCAACAAGAAGAAACCCGGGATGCCCAATGTATCTAACGACCTC
TCACAGAAACTATATGCCACCATGGAGAAGCATAAAGAGGTCTTCTTTGTGATCCGCCTC
ATTGCTGGCCCTGCTGCCAACTCCCTGCCTCCCATTGTTGATCCTGATCCTCTCATCCCC
TGCGATCTGATGGATGGTCGGGATGCGTTTCTCACGCTGGCAAGGGACAAGCACCTGGAG
TTCTCTTCACTCCGAAGAGCCCAGTGGTCCACCATGTGCATGCTGGTGGAGCTGCACACG
CAGAGCCAGGACCGCTTTGTCTACACCTGCAATGAATGCAAGCACCATGTGGAGACACGC
TGGCACTGTACTGTCTGTGAGGATTATGACTTGTGTATCACCTGCTATAACACTAAAAAC
CATGACCACAAAATGGAGAAACTAGGCCTTGGCTTAGATGATGAGAGCAACAACCAGCAG
GCTGCAGCCACCCAGAGCCCAGGCGATTCTCGCCGCCTGAGTATCCAGCGCTGCATCCAG
TCTCTGGTCCATGCTTGCCAGTGTCGGAATGCCAATTGCTCACTGCCATCCTGCCAGAAG
ATGAAGCGGGTTGTGCAGCATACCAAGGGTTGCAAACGGAAAACCAATGGCGGGTGCCCC
ATCTGCAAGCAGCTCATTGCCCTCTGCTGCTACCATGCCAAGCACTGCCAGGAGAACAAA
TGCCCGGTGCCGTTCTGCCTAAACATCAAGCAGAAGCTCCGGCAGCAACAGCTGCAGCAC
CGACTACAGCAGGCCCAAATGCTTCGCAGGAGGATGGCCAGCATGCAGCGGACTGGTGTG
GTTGGGCAGCAACAGGGCCTCCCTTCCCCCACTCCTGCCACTCCAACGACACCAACTGGC
CAACAGCCAACCACCCCGCAGACGCCCCAGCCCACTTCTCAGCCTCAGCCTACCCCTCCC
AATAGCATGCCACCCTACTTGCCCAGGACTCAAGCTGCTGGCCCTGTGTCCCAGGGTAAG
GCAGCAGGCCAGGTGACCCCTCCAACCCCTCCTCAGACTGCTCAGCCACCCCTTCCAGGG
CCCCCACCTACAGCAGTGGAAATGGCAATGCAGATTCAGAGAGCAGCGGAGACGCAGCGC
CAGATGGCCCACGTGCAAATTTTTCAAAGGCCAATCCAACACCAGATGCCCCCGATGACT
CCCATGGCCCCCATGGGTATGAACCCACCTCCCATGACCAGAGGTCCCAGTGGGCATTTG
GAGCCAGGGATGGGACCGACAGGGATGCAGCAACAGCCACCCTGGAGCCAAGGAGGATTG
CCTCAGCCCCAGCAACTACAGTCTGGGATGCCAAGGCCAGCCATGATGTCAGTGGCCCAG
CATGGTCAACCTTTGAACATGGCTCCACAACCAGGATTGGGCCAGGTAGGTATCAGCCCA
CTCAAACCAGGCACTGTGTCTCAACAAGCCTTACAAAACCTTTTGCGGACTCTCAGGTCT
CCCAGCTCTCCCCTGCAGCAGCAACAGGTGCTTAGTATCCTTCACGCCAACCCCCAGCTG
TTGGCTGCATTCATCAAGCAGCGGGCTGCCAAGTATGCCAACTCTAATCCACAACCCATC
CCTGGGCAGCCTGGCATGCCCCAGGGGCAGCCAGGGCTACAGCCACCTACCATGCCAGGT
CAGCAGGGGGTCCACTCCAATCCAGCCATGCAGAACATGAATCCAATGCAGGCGGGCGTT
CAGAGGGCTGGCCTGCCCCAGCAGCAACCACAGCAGCAACTCCAGCCACCCATGGGAGGG
ATGAGCCCCCAGGCTCAGCAGATGAACATGAACCACAACACCATGCCTTCACAATTCCGA
GACATCTTGAGACGACAGCAAATGATGCAACAGCAGCAGCAACAGGGAGCAGGGCCAGGA
ATAGGCCCTGGAATGGCCAACCATAACCAGTTCCAGCAACCCCAAGGAGTTGGCTACCCA
CCACAGCCGCAGCAGCGGATGCAGCATCACATGCAACAGATGCAACAAGGAAATATGGGA
CAGATAGGCCAGCTTCCCCAGGCCTTGGGAGCAGAGGCAGGTGCCAGTCTACAGGCCTAT
CAGCAGCGACTCCTTCAGCAACAGATGGGGTCCCCTGTTCAGCCCAACCCCATGAGCCCC
CAGCAGCATATGCTCCCAAATCAGGCCCAGTCCCCACACCTACAAGGCCAGCAGATCCCT
AATTCTCTCTCCAATCAAGTGCGCTCTCCCCAGCCTGTCCCTTCTCCACGGCCACAGTCC
CAGCCCCCCCACTCCAGTCCTTCCCCAAGGATGCAGCCTCAGCCTTCTCCACACCACGTT
TCCCCACAGACAAGTTCCCCACATCCTGGACTGGTAGCTGCCCAGGCCAACCCCATGGAA
CAAGGGCATTTTGCCAGCCCGGACCAGAATTCAATGCTTTCTCAGCTTGCTAGCAATCCA
GGCATGGCAAACCTCCATGGTGCAAGCGCCACGGACCTGGGACTCAGCACCGATAACTCA
GACTTGAATTCAAACCTCTCACAGAGTACACTAGACATACACTAG

# Macromolecular_Interacting_Partner_29_GenBank_ID_Gene:
U01877

# Macromolecular_Interacting_Partner_29_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_29_Locus:
22q13.2

# Macromolecular_Interacting_Partner_29_SNPs:
rs20551; rs1046088; rs4822012; rs20554; rs11912899; rs35560602; rs17002310; rs17002307; rs11704815; rs3210590; rs2076577; rs1569858; rs5751053; rs3818120; rs2057070; rs4822006; rs738628; rs4822011; rs5758231; rs7286979; rs5758238; rs2267424; rs5758242; rs9611510; rs5758235; rs1033611; rs4820429; rs4822004; rs5758251; rs766314; rs1983674; rs9611509; rs2064560; rs4820431; rs5758237; rs2144342; rs9619939; rs2207583; rs5751057; rs17002314; rs9623334; rs6002260; rs3818121; rs6002267; rs5751046; rs2273227; rs4822005; rs738629; rs9619941; rs9619950; rs738631; rs12167662; rs9611505; rs1569857; rs2294976; rs11090039; rs9623344; rs9611497; rs4820428; rs5758223; rs6002271; rs9623332; rs738632; rs2064558; rs5751048; rs5758241; rs2413637; rs2076578; rs12170811; rs17433014; rs2024717; rs2267426; rs5758247; rs12170429; rs17002284; rs12330117; rs4822014; rs9611503; rs7510675; rs8138205; rs730811; rs6002262; rs5751049; rs17002305; rs11912447; rs5758243; rs17002312; rs738630; rs5995996; rs5751056; rs17002318; rs5758240; rs2267425; rs2076581; rs7284319; rs5758236; rs17002301; rs5758239; rs17384028; rs4822008; rs4822010; rs8135637; rs9623331; rs11704042; rs17002304; rs8135084; rs5751058; rs17002308; rs9611500; rs4822007; rs9607772; rs4822013; rs5758228; rs5758246; rs79540; rs5751050; rs2899344; rs9607776; rs9619942; rs5751042; rs8137709; rs17002316; rs9611502; rs4822003; rs6002259; rs9623327; rs8141750; rs3788583; rs1033612; rs5758252; rs7285319; rs34013924; rs28937578; rs11350445; rs12628803; rs34985152; rs1802551; rs34842722; rs1062983; rs35530321; rs35508493; rs5845490; rs34217877; rs12158004; rs28579460; rs2076582; rs6002265; rs36083653; rs33937254; rs5751040; rs9611496; rs4820430; rs9623343; rs35609068; rs13058113; rs12168000; rs5751060; rs3216439; rs12160751; rs34818464; rs34424914; rs12169381; rs3216438; rs7285761; rs5751043; rs8142938; rs34299910; rs36012453; rs8136962; rs12628857; rs2273228; rs9623342; rs5758233; rs35609995; rs10529110; rs13057384; rs35333608; rs4822009; rs2413636; rs12160994; rs5758225; rs13057037; rs6002268; rs12165625; rs9619945; rs9607777; rs12163510; rs5758249; rs9611495; rs34942055; rs9619940; rs28391542; rs28514345; rs9619947; rs35823862; rs35350688; rs34731157; rs9607778; rs34149267; rs28477413; rs34868121; rs35121045; rs9611501; rs4605475; rs35497681; rs35669783; rs9623323; rs11362436; rs9623328; rs9623324; rs2064559; rs13056241; rs5758224; rs34711608; rs5758248; rs34509811; rs9607773; rs10854741; rs28733661; rs35616327; rs9611499; rs13053538; rs9623340; rs9611504; rs11415780; rs9623338; rs130087; rs33960382; rs5758234; rs9607774; rs5845489; rs9623339; rs9619946; rs9611508; rs34411551; rs35715259; rs11090041; rs5751041; rs11388493; rs5845488; rs12628137; rs2076579; rs5751055; rs7511178; rs35843389; rs35189661; rs34597174; rs2267427; rs34016471; rs35023864; rs5995997; rs36068453; rs11387442; rs35261244; rs1065580; rs34564005; rs34839216; rs2076580; rs9619937; rs6002274; rs9619943; rs35506286; rs13055654; rs3044636; rs5758230; rs10711010; rs35429134; rs6002266; rs130086; rs9623329; rs13055991; rs35304365; rs34339178; rs35082633; rs35403189; rs7291735; rs35343837; rs9607775; rs9611498; rs13055872; rs9619949; rs34914831; rs33917644; rs9611507; rs136393; rs28631247; rs12158776; rs13055866; rs6002269; rs13057044; rs13058482; rs34213429; rs5751051; rs35507631; rs10717148; rs3830876; rs34420363; rs11473253; rs5751045; rs35079921; rs5995998; rs17002286; rs34481158; rs5751054; rs35492332; rs11306415; rs2294977; rs9619944; rs12170320; rs5758245; rs13056242; rs35498541; rs10222217; rs9653841; rs9607779; rs13053662; rs10533459; rs28444825; rs9611506; rs35531014; rs9623336; rs4479527; rs5995993; rs7285973; rs35871884; rs12167653; rs9623335; rs9619938; rs35055551; rs34022257; rs35196722; rs1569856; rs28456102; rs5758226; rs36068041; rs35147987; rs34835519; rs34955001; rs35790144; rs35741493; rs34902876; rs12628695; rs136394; rs17002324; rs2143694; rs4822002; rs5751037; rs5758221; rs5758222; rs6002279; rs7287970

# Macromolecular_Interacting_Partner_29_General_References:
7523245; 11701890; 8945521; 8684459; 8917528; 9590696; 10823961; 11349124; 11481323; 11564735; 11744733; 12750254; 12446687; 11959990; 10700188

# Macromolecular_Interacting_Partner_29_References:
12840224; 15650166; 16456404

# Macromolecular_Interacting_Partner_30_ID:
7741

# Macromolecular_Interacting_Partner_30_Name:
Histone deacetylase 9

# Macromolecular_Interacting_Partner_30_Synonyms:
HD9; HD7B; HD7; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR

# Macromolecular_Interacting_Partner_30_Gene_Name:
HDAC9

# Macromolecular_Interacting_Partner_30_Protein_Sequence:
>Histone deacetylase 9
MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR
EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA
HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS
PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA
EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ
GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP
QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ
QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG
QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL
EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR
IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD
DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP
GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI
SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK
EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA
ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSMSLKFS

# Macromolecular_Interacting_Partner_30_Number_of_Residues:
1011

# Macromolecular_Interacting_Partner_30_Molecular_Weight:
111298

# Macromolecular_Interacting_Partner_30_Theoretical_pI:
6.88

# Macromolecular_Interacting_Partner_30_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_30_General_Function:
Not Available

# Macromolecular_Interacting_Partner_30_Specific_Function:
Isoform 3, called MITR/HDRP, lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting c-Jun phosphorylation by MAPK10 and by repressing c-Jun transcription via HDAC1 recruitment to c-Jun promoter

# Macromolecular_Interacting_Partner_30_Pathway:
Not Available

# Macromolecular_Interacting_Partner_30_Reaction:
Not Available

# Macromolecular_Interacting_Partner_30_Pfam_Domain_Function:
PF00850:Hist_deacetyl

# Macromolecular_Interacting_Partner_30_Signals:
None

# Macromolecular_Interacting_Partner_30_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_30_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_30_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_30_GenBank_ID_Protein:
15590680

# Macromolecular_Interacting_Partner_30_SwissProt_ID:
HDAC9_HUMAN (Q9UKV0)

# Macromolecular_Interacting_Partner_30_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_30_Genecard_id:
HDAC9

# Macromolecular_Interacting_Partner_30_Geneatlas_id:
HDAC9

# Macromolecular_Interacting_Partner_30_hgnc_id:
HGNC:14065

# Macromolecular_Interacting_Partner_30_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_30_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_30_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_30_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_30_Gene_Sequence:
>3036 bp
ATGCACAGTATGATCAGCTCAGTGGATGTGAAGTCAGAAGTTCCTGTGGGCCTGGAGCCC
ATCTCACCTTTAGACCTAAGGACAGACCTCAGGATGATGATGCCCGTGGTGGACCCTGTT
GTCCGTGAGAAGCAATTGCAGCAGGAATTACTTCTTATCCAGCAGCAGCAACAAATCCAG
AAGCAGCTTCTGATAGCAGAGTTTCAGAAACAGCATGAGAACTTGACACGGCAGCACCAG
GCTCAGCTTCAGGAGCATATCAAGGAACTTCTAGCCATAAAACAGCAACAAGAACTCCTA
GAAAAGGAGCAGAAACTGGAGCAGCAGAGGCAAGAACAGGAAGTAGAGAGGCATCGCAGA
GAACAGCAGCTTCCTCCTCTCAGAGGCAAAGATAGAGGACGAGAAAGGGCAGTGGCAAGT
ACAGAAGTAAAGCAGAAGCTTCAAGAGTTCCTACTGAGTAAATCAGCAACGAAAGACACT
CCAACTAATGGAAAAAATCATTCCGTGAGCCGCCATCCCAAGCTCTGGTACACGGCTGCC
CACCACACATCATTGGATCAAAGCTCTCCACCCCTTAGTGGAACATCTCCATCCTACAAG
TACACATTACCAGGAGCACAAGATGCAAAGGATGATTTCCCCCTTCGAAAAACTGCCTCT
GAGCCCAACTTGAAGGTGCGGTCCAGGTTAAAACAGAAAGTGGCAGAGAGGAGAAGCAGC
CCCTTACTCAGGCGGAAGGATGGAAATGTTGTCACTTCATTCAAGAAGCGAATGTTTGAG
GTGACAGAATCCTCAGTCAGTAGCAGTTCTCCAGGCTCTGGTCCCAGTTCACCAAACAAT
GGGCCAACTGGAAGTGTTACTGAAAATGAGACTTCGGTTTTGCCCCCTACCCCTCATGCC
GAGCAAATGGTTTCACAGCAACGCATTCTAATTCATGAAGATTCCATGAACCTGCTAAGT
CTTTATACCTCTCCTTCTTTGCCCAACATTACCTTGGGGCTTCCCGCAGTGCCATCCCAG
CTCAATGCTTCGAATTCACTCAAAGAAAAGCAGAAGTGTGAGACGCAGACGCTTAGGCAA
GGTGTTCCTCTGCCTGGGCAGTATGGAGGCAGCATCCCGGCATCTTCCAGCCACCCTCAT
GTTACTTTAGAGGGAAAGCCACCCAACAGCAGCCACCAGGCTCTCCTGCAGCATTTATTA
TTGAAAGAACAAATGCGACAGCAAAAGCTTCTTGTAGCTGGTGGAGTTCCCTTACATCCT
CAGTCTCCCTTGGCAACAAAAGAGAGAATTTCACCTGGCATTAGAGGTACCCACAAATTG
CCCCGTCACAGACCCCTGAACCGAACCCAGTCTGCACCTTTGCCTCAGAGCACGTTGGCT
CAGCTGGTCATTCAACAGCAACACCAGCAATTCTTGGAGAAGCAGAAGCAATACCAGCAG
CAGATCCACATGAACAAACTGCTTTCGAAATCTATTGAACAACTGAAGCAACCAGGCAGT
CACCTTGAGGAAGCAGAGGAAGAGCTTCAGGGGGACCAGGCGATGCAGGAAGACAGAGCG
CCCTCTAGTGGCAACAGCACTAGGAGCGACAGCAGTGCTTGTGTGGATGACACACTGGGA
CAAGTTGGGGCTGTGAAGGTCAAGGAGGAACCAGTGGACAGTGATGAAGATGCTCAGATC
CAGGAAATGGAATCTGGGGAGCAGGCTGCTTTTATGCAACAGCCTTTCCTGGAACCCACG
CACACACGTGCGCTCTCTGTGCGCCAAGCTCCGCTGGCTGCGGTTGGCATGGATGGATTA
GAGAAACACCGTCTCGTCTCCAGGACTCACTCTTCCCCTGCTGCCTCTGTTTTACCTCAC
CCAGCAATGGACCGCCCCCTCCAGCCTGGCTCTGCAACTGGAATTGCCTATGACCCCTTG
ATGCTGAAACACCAGTGCGTTTGTGGCAATTCCACCACCCACCCTGAGCATGCTGGACGA
ATACAGAGTATCTGGTCACGACTGCAAGAAACTGGGCTGCTAAATAAATGTGAGCGAATT
CAAGGTCGAAAAGCCAGCCTGGAGGAAATACAGCTTGTTCATTCTGAACATCACTCACTG
TTGTATGGCACCAACCCCCTGGACGGACAGAAGCTGGACCCCAGGATACTCCTAGGTGAT
GACTCTCAAAAGTTTTTTTCCTCATTACCTTGTGGTGGACTTGGGGTGGACAGTGACACC
ATTTGGAATGAGCTACACTCGTCCGGTGCTGCACGCATGGCTGTTGGCTGTGTCATCGAG
CTGGCTTCCAAAGTGGCCTCAGGAGAGCTGAAGAATGGGTTTGCTGTTGTGAGGCCCCCT
GGCCATCACGCTGAAGAATCCACAGCCATGGGGTTCTGCTTTTTTAATTCAGTTGCAATT
ACCGCCAAATACTTGAGAGACCAACTAAATATAAGCAAGATATTGATTGTAGATCTGGAT
GTTCACCATGGAAACGGTACCCAGCAGGCCTTTTATGCTGACCCCAGCATCCTGTACATT
TCACTCCATCGCTATGATGAAGGGAACTTTTTCCCTGGCAGTGGAGCCCCAAATGAGGTT
GGAACAGGCCTTGGAGAAGGGTACAATATAAATATTGCCTGGACAGGTGGCCTTGATCCT
CCCATGGGAGATGTTGAGTACCTTGAAGCATTCAGGACCATCGTGAAGCCTGTGGCCAAA
GAGTTTGATCCAGACATGGTCTTAGTATCTGCTGGATTTGATGCATTGGAAGGCCACACC
CCTCCTCTAGGAGGGTACAAAGTGACGGCAAAATGTTTTGGTCATTTGACGAAGCAATTG
ATGACATTGGCTGATGGACGTGTGGTGTTGGCTCTAGAAGGAGGACATGATCTCACAGCC
ATCTGTGATGCATCAGAAGCCTGTGTAAATGCCCTTCTAGGAAATGAGCTGGAGCCACTT
GCAGAAGATATTCTCCACCAAAGCCCGAATATGAATGCTGTTATTTCTTTACAGAAGATC
ATTGAAATTCAAAGTATGTCTTTAAAGTTCTCTTAA

# Macromolecular_Interacting_Partner_30_GenBank_ID_Gene:
AY032737

# Macromolecular_Interacting_Partner_30_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_30_Locus:
7p21.1

# Macromolecular_Interacting_Partner_30_SNPs:
rs1178127; rs17140166; rs34096894; rs2389998; rs35614472; rs7776735; rs7812296; rs706086; rs2526630; rs2074633; rs17139546; rs17348528; rs801524; rs17150251; rs2023938; rs2526631; rs957960; rs1178178; rs1178128; rs1726609; rs1178171; rs431; rs2188320; rs1178103; rs1178132; rs2028016; rs2695026; rs2520339; rs2588637; rs1178106; rs2520360; rs2520458; rs2520462; rs2073962; rs2588603; rs1178114; rs1178122; rs756789; rs212672; rs2519739; rs1178176; rs1629017; rs2073974; rs1034805; rs1178109; rs1726597; rs1726610; rs1178101; rs2106362; rs1178174; rs1178131; rs1557696; rs1178123; rs2588596; rs2257696; rs2016515; rs1178180; rs1018870; rs2588601; rs2519890; rs2588597; rs2588623; rs2073963; rs2520343; rs1548578; rs801540; rs2240281; rs212666; rs2853554; rs2189741; rs2588606; rs1178117; rs1178118; rs1178172; rs2526633; rs2023650; rs1178099; rs812395; rs2269923; rs1978191; rs1178111; rs723157; rs2526632; rs801541; rs1178164; rs2520355; rs2285431; rs212671; rs1178112; rs2106506; rs1726595; rs1178098; rs2526639; rs1726614; rs2588600; rs1011446; rs706087; rs1178165; rs2269924; rs2717351; rs1178179; rs2588635; rs9918514; rs12056043; rs6461396; rs6965278; rs1633789; rs6950979; rs2717342; rs801522; rs6948023; rs6461381; rs2269754; rs6967723; rs801539; rs2285438; rs2188321; rs726805; rs1615309; rs7788833; rs13438248; rs6461393; rs6954476; rs4721722; rs7807182; rs13241157; rs2285440; rs10276613; rs2023651; rs212664; rs2022090; rs2389995; rs813902; rs801767; rs768830; rs1859664; rs6954945; rs7806011; rs2519745; rs6969674; rs1076161; rs3901892; rs1178120; rs1178113; rs1633986; rs972400; rs801521; rs7456989; rs10272939; rs10268296; rs6946945; rs10250414; rs2526640; rs3213616; rs1178107; rs801760; rs2254993; rs4721717; rs10261942; rs1178119; rs3852257; rs801525; rs10280805; rs12533274; rs6951128; rs2286213; rs2389963; rs1178121; rs4721732; rs7779024; rs10281656; rs3852256; rs6461383; rs10252945; rs6979890; rs6972136; rs10228036; rs2390042; rs2157901; rs2588625; rs2717353; rs10272709; rs11765532; rs1178167; rs1178163; rs2239927; rs11983879; rs2249817; rs11977190; rs2695023; rs4721721; rs3852248; rs2717357; rs6965090; rs10268180; rs11767043; rs6461382; rs4721719; rs2269752; rs10271724; rs6952102; rs6461389; rs10950704; rs1918282; rs7808451; rs7794273; rs2528406; rs10269422; rs6963568; rs1178168; rs6980276; rs6977304; rs6461395; rs1178126; rs739457; rs2286003; rs7778211; rs2717356; rs2239926; rs7795433; rs6969316; rs7788972; rs1633779; rs7779555; rs4721720; rs2526641; rs6947529; rs10274006; rs10277631; rs7796939; rs6973063; rs1990115; rs957958; rs2073973; rs13230142; rs13241130; rs726116; rs6961943; rs2520348; rs10264011; rs6951522; rs2588633; rs1178102; rs7796078; rs2588605; rs801763; rs11505303; rs10274009; rs3852251; rs6979341; rs11764116; rs6461394; rs7798646; rs2190278; rs2254859; rs6950235; rs7809412; rs2588602; rs7808375; rs12535294; rs10223990; rs2526636; rs6968715; rs6959028; rs6973548; rs10237404; rs6951144; rs10226243; rs12540265; rs2695029; rs2066956; rs10486317; rs2214090; rs2717349; rs7787721; rs2285443; rs1178116; rs6461385; rs1178110; rs10253444; rs2269753; rs2853552; rs2520336; rs183325; rs801537; rs2528409; rs6967021; rs1476657; rs6461386; rs6950202; rs801758; rs1633987; rs4141402; rs11981267; rs10257046; rs10261390; rs3852253; rs2160543; rs1015407; rs756853; rs10266268; rs3807907; rs1178100; rs10225230; rs12056282; rs10237149; rs13245206; rs2073965; rs3910833; rs4721725; rs1554774; rs801519; rs10486318; rs1178170; rs2190276; rs7810384; rs4484585; rs2541318; rs6972607; rs7801849; rs801510; rs10237280; rs1178130; rs6960494; rs10227612; rs10280633; rs1726594; rs6962675; rs7811828; rs756790; rs11764843; rs1178108; rs801534; rs968842; rs10252839; rs13238389; rs6958865; rs2519889; rs6461384; rs11975297; rs10234134; rs2158768; rs2269748; rs2389992; rs2519746; rs10276724; rs3807917; rs4721729; rs4721715; rs3852254; rs2520345; rs6955959; rs6968777; rs3852255; rs17140345; rs10229723; rs10486293; rs11977090; rs12699984; rs10228341; rs10486323; rs17434924; rs2588627; rs9639321; rs17351069; rs17140251; rs6973918; rs10281987; rs17433319; rs2588609; rs7789752; rs2965026; rs1726602; rs10229062; rs17140423; rs11762171; rs6963748; rs17139975; rs17435661; rs1005139; rs12700005; rs10486312; rs2188495; rs1178143; rs1089358; rs13234273; rs10242218; rs9639319; rs1178105; rs801512; rs2588636; rs2588638; rs2520361; rs17140399; rs10282189; rs1633775; rs17139847; rs3807918; rs10278449; rs12670036; rs3814986; rs3823969; rs1918283; rs2024022; rs10486325; rs177080; rs10223954; rs10236906; rs7789378; rs10247238; rs12699985; rs801520; rs2520353; rs11761877; rs10282136; rs6949444; rs11973923; rs2704282; rs13231835; rs3807919; rs7811778; rs2285430; rs801516; rs12536081; rs1178155; rs11979779; rs2520358; rs2158495; rs1178156; rs10278707; rs10234485; rs13238305; rs17432977; rs6951745; rs9632592; rs1178177; rs1405618; rs3814985; rs1089357; rs6461392; rs2588599; rs1178129; rs1990116; rs7788731; rs17435702; rs801513; rs10249580; rs10245010; rs1633787; rs17432462; rs7782894; rs12700007; rs1624397; rs9648246; rs3814992; rs13243526; rs9655159; rs12536836; rs2301949; rs7802855; rs11972573; rs17139867; rs17140138; rs17350355; rs1178134; rs1726612; rs4721718; rs6967030; rs10265445; rs6977642; rs13231656; rs727851; rs3814993; rs2717339; rs10241099; rs6950598; rs13241957; rs3814989; rs6976460; rs10486330; rs12539715; rs13438582; rs2588604; rs929196; rs11977498; rs10266741; rs10242505; rs2519738; rs2157847; rs2520346; rs10245269; rs1178115; rs3757718; rs13232564; rs17140198; rs6972422; rs4141042; rs2285439; rs17139630; rs2588639; rs3852250; rs1178162; rs12669789; rs12535092; rs17150238; rs7808313; rs3887252; rs17349342; rs6974299; rs3807925; rs3864420; rs17139615; rs993082; rs11762829; rs7776786; rs17140017; rs10270954; rs3807909; rs11543651; rs7803715; rs11980610; rs10247184; rs4721726; rs10258770; rs7808621; rs801535; rs10270212; rs2520362; rs10254059; rs10253169; rs10486329; rs2519737; rs10249700; rs17139510; rs16872139; rs1178125; rs13241140; rs13221164; rs13234562; rs2704280; rs6954162; rs10259495; rs10246722; rs3901683; rs3910828; rs10486315; rs11982735; rs801768; rs1726596; rs2541321; rs3801986; rs11977467; rs12672843; rs11768780; rs2285442; rs10248565; rs17350236; rs2853556; rs9655161; rs6973029; rs2588634; rs1178166; rs1178148; rs11978963; rs3814991; rs2107596; rs12533489; rs7794241; rs10264621; rs3801985; rs10259213; rs6960766; rs10264832; rs10231651; rs11984282; rs2704281; rs17350431; rs2078869; rs6977299; rs17140193; rs2519891; rs1178133; rs706085; rs12669760; rs7807037; rs2240280; rs894978; rs2246313; rs11975390; rs17140170; rs17140363; rs10261308; rs3852252; rs6961395; rs3213615; rs7811991; rs2520354; rs10237366; rs10486314; rs4001107; rs2285437; rs17140086; rs10235067; rs10441039; rs10486310; rs10441038; rs12539764; rs2695027; rs4721728; rs1178160; rs3757717; rs11982970; rs7790924; rs968841; rs7801662; rs2240279; rs801508; rs3807922; rs12533452; rs3807920; rs17349860; rs2073964; rs12699995; rs6959501; rs1178150; rs7798677; rs801514; rs17140374; rs6956139; rs1089359; rs12113191; rs17139769; rs17432448; rs13246896; rs10486289; rs4721716; rs17139504; rs17350383; rs2519740; rs17349622; rs17140133; rs10243224; rs717982; rs11980192; rs12540774; rs13227668; rs801759; rs7788734; rs3757716; rs4445123; rs17140258; rs17140158; rs1178159; rs801523; rs10245874; rs10243888; rs3801983; rs10277107; rs9639320; rs6461387; rs801515; rs17139817; rs2717344; rs6461390; rs12540224; rs1178144; rs17139557; rs2301950; rs17139857; rs11984041; rs2078866; rs17139842; rs12699996; rs12700009; rs7783171; rs2190277; rs10224196; rs10486327; rs11975907; rs2520352; rs6461397; rs12531908; rs6950376; rs801511; rs4721723; rs3807901; rs11505418; rs1178149; rs2520460; rs17150249; rs10272295; rs17139913; rs11982807; rs169871; rs13233322; rs17139283; rs11982615; rs10258269; rs2704283; rs17139704; rs7789723; rs2588622; rs2188322; rs212665; rs10231336; rs10486292; rs17139544; rs6974604; rs17139278; rs17139316; rs1405615; rs1079954; rs1178142; rs10235695; rs10950705; rs4605958; rs17140418; rs1178169; rs6952297; rs7801553; rs6947318; rs10247766; rs2965027; rs2214850; rs2285433; rs10248443; rs2028013; rs13238221; rs17139763; rs10270210; rs801526; rs7780629; rs13238702; rs2519744; rs17350515; rs801538; rs17350397; rs7780397; rs11980989; rs2520359; rs7459007; rs2285436; rs10230491; rs2240419; rs17433123; rs17139344; rs10241929; rs2520351; rs13224833; rs2520344; rs10215410; rs1918284; rs7803518; rs2588628; rs10240305; rs2704289; rs10244193; rs17139516; rs1980368; rs6651064; rs6956490; rs6950420; rs12539449; rs2190275; rs212670; rs7801037; rs10228382; rs17139854; rs17140253; rs17139840; rs801517; rs2240278; rs9918521; rs12700010; rs7808698; rs3854289; rs10251998; rs13238035; rs801530; rs2853557; rs10274126; rs2157900; rs17350341; rs6974011; rs2526637; rs2190273; rs11763653; rs12669473; rs17435730; rs212663; rs10253478; rs7779171; rs17433095; rs2965029; rs2588607; rs10260390; rs10237177; rs17139789; rs10247256; rs2028014; rs17139571; rs12672635; rs2285435; rs17139365; rs11983126; rs801761; rs12539747; rs7777856; rs17150253; rs10265632; rs13224263; rs801507; rs11973076; rs2520457; rs10263618; rs1633791; rs17139554; rs2389997; rs17139508; rs10243892; rs212669; rs2704284; rs1182736; rs10277165; rs7455344; rs7780101; rs2520349; rs7803235; rs4721734; rs6968894; rs212673; rs12700012; rs2190274; rs2588631; rs10266607; rs13234557; rs2717352; rs212662; rs16872155; rs10261429; rs1405616; rs10281362; rs6955566; rs17139401; rs17350229; rs10251867; rs7781098; rs17139451; rs10276216; rs10272517; rs10236109; rs10486316; rs11982882; rs17139861; rs17140014; rs7793637; rs3823968; rs17139947; rs2520456; rs7455862; rs10253041; rs17348617; rs10224035; rs17139610; rs7785029; rs2285432; rs10240266; rs12113679; rs10224678; rs12700001; rs2526638; rs7784004; rs1178146; rs17140022; rs7455192; rs10237427; rs10253117; rs17150245; rs17139396; rs10266064; rs7789450; rs7806036; rs17432782; rs10215908; rs1178158; rs2520341; rs10273908; rs17139658; rs12700011; rs10252281; rs10267406; rs3807915; rs17140010; rs7780546; rs3814990; rs1554772; rs7780396; rs10225036; rs1178173; rs2541323; rs17139921; rs10244908; rs1554771; rs2839834; rs5011547; rs212674; rs7785216; rs706084; rs756854; rs11970952; rs17139319; rs1178124; rs10224266; rs2541316; rs2695028; rs6968045; rs212661; rs13235810; rs17349832; rs10232282; rs993083; rs2892905; rs801533; rs4721735; rs12056184; rs1117533; rs2717348; rs2243880; rs6946788; rs35827444; rs17139894; rs12668871; rs1405619; rs13229874; rs17140333; rs2520335; rs2520357; rs17140244; rs12699981; rs10256595; rs10247255; rs2308213; rs2588612; rs10241000; rs17140431; rs6944365; rs2541322; rs11973986; rs12700014; rs10268558; rs17433270; rs7804088; rs17139280; rs1726599; rs6958814; rs10235392; rs7780385; rs10263220; rs2853555; rs3901982; rs12699982; rs1989817; rs3852249; rs10251026; rs17140220; rs17140286; rs212668; rs12540872; rs7780668; rs801532; rs17139758; rs12530943; rs12530952; rs17139619; rs1726600; rs12539229; rs10234685; rs6955855; rs17139311; rs10261637; rs12171607; rs7799557; rs4413678; rs17140387; rs11765005; rs17140104; rs10242336; rs11977303; rs801529; rs7798921; rs1178147; rs6972767; rs7799349; rs12530969; rs10241413; rs3855596; rs10245511; rs7795954; rs12699991; rs7789261; rs10264800; rs6651065; rs2028015; rs2717358; rs10234468; rs2158494; rs2078867; rs2520337; rs10237624; rs6951973; rs7784812; rs11766784; rs10252543; rs12699983; rs10248070; rs10267142; rs2440598; rs801528; rs6461391; rs2717350; rs6973675; rs1178152; rs1405617; rs12700004; rs11974250; rs13239610; rs1726601; rs17139896; rs7777331; rs10249862; rs801765; rs10486291; rs2520363; rs2588621; rs13244868; rs7802878; rs4379363; rs2519747; rs7812153; rs801527; rs11973990; rs17140227; rs2024021; rs12535768; rs10281075; rs16872067; rs12539815; rs9886098; rs11978418; rs10230426; rs3807921; rs17140149; rs10249414; rs1918285; rs7782319; rs13239638; rs13237090; rs212667; rs17139675; rs10046476; rs7783209; rs212675; rs2028012; rs11970990; rs2519741; rs17139560; rs17140237; rs3757720; rs2023937; rs17347842; rs35691757; rs4607511; rs34282407; rs35409100; rs4391313; rs35201317; rs11459782; rs28368369; rs34279008; rs35157147; rs13233302; rs17150262; rs7786280; rs13228422; rs34931172; rs4719537; rs13229726; rs34720287; rs10716963; rs11767940; rs2588630; rs2204605; rs3841499; rs28559740; rs35497056; rs1527274; rs13225984; rs28634669; rs34163887; rs28711567; rs10707338; rs6961101; rs4721736; rs801764; rs801518; rs10614926; rs13242358; rs5882665; rs12699994; rs12056180; rs35444683; rs35812044; rs11308716; rs11337572; rs5882663; rs13312243; rs35203023; rs5882685; rs13240439; rs13227230; rs13235616; rs34082340; rs35959076; rs13230679; rs6978417; rs13240422; rs2965025; rs28463874; rs34482909; rs2158496; rs34388101; rs2520350; rs6969976; rs35330871; rs36047664; rs2588629; rs3891716; rs12539329; rs28636374; rs1178154; rs5882664; rs6947860; rs34409566; rs2588594; rs4043163; rs35016592; rs6959575; rs35967730; rs34574212; rs35576834; rs34956033; rs3216880; rs34309365; rs10280899; rs17139681; rs35812862; rs10224204; rs1178157; rs28379904; rs35296958; rs12539039; rs2301590; rs28477889; rs34605906; rs35094737; rs36039150; rs11451343; rs35351061; rs35933646; rs12699997; rs7458572; rs34511470; rs6461388; rs35278511; rs35255822; rs4043674; rs3840627; rs13235779; rs34633937; rs2695025; rs10156052; rs35248186; rs11418791; rs3085465; rs10245469; rs13240430; rs34797020; rs35092939; rs2301591; rs3084516; rs1527273; rs7807789; rs28600831; rs35229257; rs1980367; rs34240713; rs28636957; rs35711806; rs6946247; rs6952629; rs13239807; rs34787008; rs35994068; rs28562712; rs35848123; rs2717343; rs1726584; rs10229559; rs13225057; rs35993578; rs34688000; rs34979997; rs34196671; rs34341332; rs4719542; rs35678026; rs34977439; rs2588595; rs35752679; rs6969022; rs4719536; rs12154657; rs35924732; rs12700006; rs11388709; rs13222827; rs34162765; rs3854290; rs801509; rs4721737; rs12530778; rs35277570; rs2520461; rs28824774; rs36021638; rs28465160; rs2704295; rs2389994; rs35187226; rs2704292; rs10264358; rs35449622; rs3214108; rs34149953; rs6980191; rs35024729; rs35895317; rs35305527; rs34667664; rs13222822; rs10215803; rs34716480; rs34432130; rs34924821; rs12537096; rs34302776; rs36198663; rs13235460; rs35870846; rs34385627; rs35057182; rs1178153; rs2520347; rs11381401; rs13227916; rs35936891; rs5882679; rs35315535; rs35112564; rs1858903; rs12672380; rs34857064; rs3214116; rs717983; rs13243554; rs35587017; rs7458543; rs12671114; rs28497492; rs35454576; rs10277147; rs5882667; rs10253557; rs35340229; rs41273072; rs2526642; rs7795948; rs10261268; rs10268544; rs13226687; rs1476472; rs10671468; rs34262506; rs35296026; rs10275404; rs4043672; rs801531; rs5882676; rs5882682; rs35213806; rs2528407; rs28653029; rs28651961; rs34279083; rs1178140; rs2704286; rs34580817; rs6955525; rs3757719; rs28562781; rs1178104; rs17140231; rs4620175; rs4001106; rs35144869; rs34569140; rs12700000; rs28712504; rs34410437; rs36198766; rs35089454; rs34719027; rs34872310; rs2078868; rs35912823; rs5882680; rs34790980; rs5882690; rs10553612; rs5882687; rs34174659; rs10262002; rs13239170; rs35493266; rs35905914; rs28507946; rs10233694; rs28412143; rs35728273; rs36120359; rs28726229; rs34371333; rs36126241; rs4719535; rs13231902; rs35636834; rs1306444; rs34205559; rs35930688; rs4043670; rs10664010; rs35895810; rs36199570; rs212676; rs34366508; rs34618311; rs28562391; rs35041323; rs35437686; rs10226794; rs35499273; rs35692319; rs11767937; rs41273069; rs2588632; rs34379636; rs1178175; rs11327408; rs13238200; rs35689821; rs5882681; rs13231903; rs3084518; rs2588619; rs35622841; rs10713737; rs2157848; rs1726604; rs28597795; rs34800999; rs35536634; rs4573147; rs13241772; rs801766; rs35334608; rs11308990; rs11768313; rs10252885; rs13238092; rs34018423; rs10606383; rs35729003; rs34954969; rs2520364; rs2248166; rs34314311; rs35457342; rs2519743; rs34285752; rs28684496; rs8180760; rs3815193; rs34609070; rs35648258; rs4721727; rs1527275; rs35841351; rs3214216; rs2704290; rs34751779; rs13241874; rs5882666; rs4719538; rs34155355; rs28558591; rs6957711; rs35317563; rs36047659; rs3084722; rs28615740; rs13225982; rs4001105; rs35112815; rs28418568; rs35952151; rs34367677; rs10607388; rs10583381; rs1060644; rs12539520; rs34371245; rs10233651; rs3807898; rs13222773; rs169870; rs7776647; rs35354025; rs28436911; rs36109077; rs34326798; rs34165296; rs28444384; rs34209277; rs35274626; rs10667801; rs13239127; rs28464929; rs10599852; rs11394184; rs10613485; rs12699999; rs6966621; rs2695031; rs35113543; rs13243833; rs2704296; rs36219354; rs34559757; rs33953087; rs35271883; rs35839657; rs13244490; rs34707237; rs11306117; rs34574947; rs2588626; rs11443603; rs5882677; rs10573875; rs13241885; rs34383618; rs35476249; rs36036184; rs34620445; rs13223938; rs10561154; rs2520356; rs34236489; rs34790628; rs13231200; rs35242513; rs34258165; rs35922999; rs10276963; rs2695024; rs11298745; rs2389996; rs28490273; rs35824820; rs2588598; rs35807742; rs11982154; rs35240820; rs34065924; rs1726615; rs11768078; rs2717355; rs3216876; rs7797355; rs28565563; rs10275158; rs34349667; rs5022872; rs5882670; rs2269750; rs2520455; rs35673681; rs28558159; rs13239128; rs35623543; rs10580938; rs1125817; rs28465488; rs28413528; rs2704288; rs28459126; rs35753491; rs10274167; rs6150011; rs34173167; rs11976337; rs11351795; rs10566836; rs34376401; rs2695030; rs34685546; rs10275151; rs809045; rs10272035; rs13241480; rs10644628; rs10441036; rs34821051; rs34556374; rs35080681; rs1980366; rs34739935; rs3807924; rs11381062; rs2526635; rs1178137; rs13222762; rs2057821; rs11423578; rs34521762; rs34895513; rs7809331; rs2519742; rs28754411; rs35286474; rs13235348; rs35422354; rs6948613; rs4496866; rs36014102; rs35422133; rs34906576; rs957959; rs1527271; rs5882674; rs36075894; rs13245836; rs10696918; rs35167925; rs13310387; rs1622717; rs28633468; rs28709047; rs2520342; rs2853553; rs35056400; rs35820479; rs35338088; rs12539967; rs35977400; rs13230346; rs10587630; rs35147513; rs36100341; rs10252814; rs11352528; rs7797015; rs17140088; rs6150012; rs2106361; rs13308348; rs36050256; rs34512827; rs13224579; rs10243449; rs4478470; rs6974492; rs34594276; rs35353333; rs10280885; rs34032729; rs35378236; rs2965028; rs2301589; rs34921121; rs11543622; rs35526519; rs2717354; rs2051923; rs28587220; rs28539032; rs28498417; rs35458239; rs28459772; rs801762; rs11979465; rs12700002; rs769132; rs35706134; rs35767316; rs16872130; rs11410404; rs10246593; rs28652749; rs17139823; rs10275157; rs35015098; rs36216270; rs2695021; rs3857710; rs3807910; rs34987742; rs12055954; rs35185507; rs35857025; rs34048515; rs35599939; rs34114749; rs34646502; rs801536; rs2541320; rs5882675; rs172476; rs2695022; rs2285434; rs2704285; rs11348285; rs35779976; rs2588613; rs13228428; rs10230466; rs28410682; rs2588624; rs34814015; rs35528531; rs35426279; rs11385376; rs10573876; rs34896059; rs28811631; rs10567506; rs5882684; rs34805240; rs5882668; rs35289984; rs28631781; rs13242758; rs2853558; rs3807923; rs35088007; rs3214109; rs212677; rs35107667; rs28690889; rs1978072; rs34687639; rs11765209; rs28520008; rs35573809; rs10280856; rs13231304; rs34449742; rs2389999; rs12700003; rs34451381; rs28674699; rs3216881; rs36107809; rs1633982; rs34967225; rs28759229; rs34825618; rs34910827; rs13222043; rs34701409; rs10269572; rs10678670; rs13246595; rs28571726; rs6958369; rs34699073; rs28697972; rs11388242; rs10226245; rs35586562; rs34999300; rs2389993; rs10245337; rs11312304; rs34710369; rs34592963; rs12699998; rs1178139; rs6952549; rs34052960; rs35414332; rs12672415; rs2695020; rs35048169; rs1012658; rs35714495; rs2704297; rs6978681; rs33919260; rs1974489; rs13238644; rs2390041; rs4721738; rs2704291; rs28694625; rs34271373; rs35126547; rs34239413; rs28447433; rs41273075; rs10253743; rs28700157; rs3807916; rs35450308; rs5882672; rs28630018; rs28475856; rs28550369; rs2269747; rs28712749; rs2073975; rs4379362; rs6946886; rs10281766; rs12532942; rs5882673; rs34293829; rs3214107; rs28419057; rs41273078; rs35215030; rs36107669; rs13226069; rs34488992; rs35667102; rs17140226; rs36087105; rs34010659; rs28421316; rs10224198; rs2520340; rs11505416; rs10241581; rs13222764; rs11332205; rs10256357; rs1054178; rs2526634; rs3085467; rs28489181; rs16872149; rs13235453; rs3084755; rs5882683; rs4560704; rs1726608; rs1178222; rs3085431; rs6974469; rs28628267; rs13235553; rs28767930; rs35211946; rs35997540; rs35351919; rs7790376; rs17139884; rs5007139; rs17139923; rs13309163; rs35677313; rs1178138; rs35194159; rs2528408; rs1178141; rs35536284; rs36199448; rs28739368; rs5882671; rs34307478; rs13310264; rs34899469; rs34738573; rs2389927; rs1859663; rs34885265; rs10282165; rs3807908; rs13228580; rs36203178; rs12700013; rs11325618; rs36106556; rs1178151; rs3844320; rs34776880; rs11412900; rs2269751; rs751185; rs6951519; rs36074895; rs34854568; rs12055896; rs2906046; rs13239802; rs7458544; rs1633790; rs34358745; rs34840095; rs35395539; rs1178135; rs34025201; rs801757; rs9655160; rs11364088; rs1633993; rs10235499; rs34635798; rs35521033; rs10228641; rs34098679; rs1962774; rs36198668; rs10254903; rs12536615; rs10281822; rs10230371; rs35374719; rs10580574; rs5022871; rs10046581; rs35930288; rs35145987; rs28401174; rs1527272; rs1178136; rs10244626; rs10225951; rs35074349; rs10605389; rs11357950; rs35157772; rs4590333; rs10240128; rs35285583; rs35788528; rs34875036; rs2023652; rs5882686; rs1726585; rs13310129; rs34392281; rs12055953; rs11347832; rs35803639; rs34038989; rs10950703; rs6945057; rs34905635; rs13347372; rs10275281; rs5882669; rs34701084; rs2285441; rs4721724; rs2519725; rs34474069; rs11531457; rs34910054; rs10241753; rs10241964; rs10245779; rs10266369; rs13225078; rs13247382; rs2023936; rs2051920; rs2158493; rs2526619; rs2526621; rs2526622; rs2526623; rs2526624; rs2526625; rs2526626; rs2526627; rs2526629; rs2717346; rs4266547; rs432; rs433; rs434; rs7792656; rs7798197; rs7807970

# Macromolecular_Interacting_Partner_30_General_References:
11535832; 12706107; 12590135; 9872452; 12853948; 10523670; 10487760; 10487761; 12032081

# Macromolecular_Interacting_Partner_30_References:
12840228; 14750171; 14989149; 15093136

# Macromolecular_Interacting_Partner_31_ID:
8462

# Macromolecular_Interacting_Partner_31_Name:
Leukocyte antigen

# Macromolecular_Interacting_Partner_31_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_31_Gene_Name:
HLA-DRB5new

# Macromolecular_Interacting_Partner_31_Protein_Sequence:
>Leukocyte antigen
RFLQQDKYECHFFNGTERVRFLHRDIYNQEEDLRFDSDVGEYRAVTELGRPDAEYWNSQK
DILEQARAAVDTYCRHNYGAVESFTVQRR

# Macromolecular_Interacting_Partner_31_Number_of_Residues:
89

# Macromolecular_Interacting_Partner_31_Molecular_Weight:
10771

# Macromolecular_Interacting_Partner_31_Theoretical_pI:
5.17

# Macromolecular_Interacting_Partner_31_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_31_General_Function:
Not Available

# Macromolecular_Interacting_Partner_31_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_31_Pathway:
Not Available

# Macromolecular_Interacting_Partner_31_Reaction:
Not Available

# Macromolecular_Interacting_Partner_31_Pfam_Domain_Function:
PF00969:MHC_II_beta

# Macromolecular_Interacting_Partner_31_Signals:
None

# Macromolecular_Interacting_Partner_31_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_31_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_31_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_31_GenBank_ID_Protein:
1914731

# Macromolecular_Interacting_Partner_31_SwissProt_ID:
O00157_HUMAN (O00157)

# Macromolecular_Interacting_Partner_31_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_31_Genecard_id:
HLA-DRB5new

# Macromolecular_Interacting_Partner_31_Geneatlas_id:
HLA-DRB5new

# Macromolecular_Interacting_Partner_31_hgnc_id:
HGNC:4953

# Macromolecular_Interacting_Partner_31_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_31_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_31_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_31_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_31_Gene_Sequence:
>269 bp
CACGTTTCTTGCAGCAGGATAAGTATGAGTGTCATTTCTTCAACGGGACGGAGCGGGTGC
GGTTCCTGCACAGAGACATCTATAACCAAGAGGAGGACTTGCGCTTCGACAGCGACGTGG
GGGAGTACCGGGCGGTGACGGAGCTGGGGCGGCCTGACGCTGAGTACTGGAACAGCCAGA
AGGACATCCTGGAGCAGGCGCGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGG
CTGTGGAGAGCTTCACAGTGCAGCGGCGA

# Macromolecular_Interacting_Partner_31_GenBank_ID_Gene:
Z83201

# Macromolecular_Interacting_Partner_31_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_31_Locus:
Not Available

# Macromolecular_Interacting_Partner_31_SNPs:
Not Available

# Macromolecular_Interacting_Partner_31_General_References:
9226128

# Macromolecular_Interacting_Partner_31_References:
15142888; 15208660

# Macromolecular_Interacting_Partner_32_ID:
7975

# Macromolecular_Interacting_Partner_32_Name:
Tyrosine 3-monooxygenase

# Macromolecular_Interacting_Partner_32_Synonyms:
Tyrosine 3-hydroxylase; TH

# Macromolecular_Interacting_Partner_32_Gene_Name:
TH

# Macromolecular_Interacting_Partner_32_Protein_Sequence:
>Tyrosine 3monooxygenase
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTP
RSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPR
ATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVR
QVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEI
AFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNI
PQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCC
HELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQNGEVKAYG
AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYAS
RIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG

# Macromolecular_Interacting_Partner_32_Number_of_Residues:
528

# Macromolecular_Interacting_Partner_32_Molecular_Weight:
58525

# Macromolecular_Interacting_Partner_32_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_32_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  tyrosine 3-monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  catecholamine metabolism
Process:  catecholamine biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_32_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_32_Specific_Function:
Plays an important role in the physiology of adrenergic neurons

# Macromolecular_Interacting_Partner_32_Pathway:
map00350  Tyrosine metabolism

# Macromolecular_Interacting_Partner_32_Reaction:
L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin

# Macromolecular_Interacting_Partner_32_Pfam_Domain_Function:
PF00351:Biopterin_H

# Macromolecular_Interacting_Partner_32_Signals:
None

# Macromolecular_Interacting_Partner_32_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_32_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_32_EC_Link:
EC 1.14.16.2

# Macromolecular_Interacting_Partner_32_GenBank_ID_Protein:
37127

# Macromolecular_Interacting_Partner_32_SwissProt_ID:
TY3H_HUMAN (P07101)

# Macromolecular_Interacting_Partner_32_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_32_Genecard_id:
TH

# Macromolecular_Interacting_Partner_32_Geneatlas_id:
TH

# Macromolecular_Interacting_Partner_32_hgnc_id:
HGNC:11782

# Macromolecular_Interacting_Partner_32_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_32_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_32_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_32_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_32_Gene_Sequence:
>1575 bp
ATGCCCACCCCCGACGCCACCACGCCACAGGCCAAGGGCTTCCGCAGGGCCGTGTCTGAG
CTGGACGCCAAGCAGGCAGAGGCCATCATGGGCGCCCCGGGGCCCAGCCTCACAGGCTCT
CCGTGGCCTGGAACTGCAGCCCCAGCTGCATCCTACACCCCCACCCCAAGGTCCCCGCGG
TTCATTGGGCGCAGGCAGAGCCTCATCGAGGACGCCCGCAAGGAGCGGGAGGCGGCGGTG
GCAGCAGCGGCCGCTGCAGTCCCCTCGGAGCCCGGGGACCCCCTGGAGGCTGTGGCCTTT
GAGGAGAAGGAGGGGAAGGCCGTGCTAAACCTGCTCTTCTCCCCGAGGGCCACCAAGCCC
TCGGCGCTGTCCCGAGCTGTGAAGGTGTTTGAGACGTTTGAAGCCAAAATCCACCATCTA
GAGACCCGGCCCGCCCAGAGGCCGCGAGCTGGGGGCCCCCACCTGGAGTACTTCGTGCGC
CTCGAGGTGCGCCGAGGGGACCTGGCCGCCCTGCTCAGTGGTGTGCGCCAGGTGTCAGAG
GACGTGCGCAGCCCCGCGGGGCCCAAGGTCCCCTGGTTCCCAAGAAAAGTGTCAGAGCTG
GACAAGTGTCATCACCTGGTCACCAAGTTCGACCCTGACCTGGACTTGGACCACCCGGGC
TTCTCGGACCAGGTGTACCGCCAGCGCAGGAAGCTGATTGCTGAGATCGCCTTCCAGTAC
AGGCACGGCGACCCGATTCCCCGTGTGGAGTACACCGCCGAGGAGATTGCCACCTGGAAG
GAGGTCTACACCACGCTGAAGGGCCTCTACGCCACGCACGCCTGCGGGGAGCACCTGGAG
GCCTTTGCTTTGCTGGAGCGCTTCAGCGGCTACCGGGAAGACAATATCCCCCAGCTGGAG
GACGTCTCCCGCTTCCTGAAGGAGCGCACGGGCTTCCAGCTGCGGCCTGTGGCCGGCCTG
CTGTCCGCCCGGGACTTCCTGGCCAGCCTGGCCTTCCGCGTGTTCCAGTGCACCCAGTAT
ATCCGCCACGCGTCCTCGCCCATGCACTCCCCTGAGCCGGACTGCTGCCACGAGCTGCTG
GGGCACGTGCCCATGCTGGCCGACCGCACCTTCGCGCAGTTCTCGCAGGACATTGGCCTG
GCGTCCCTGGGGGCCTCGGATGAGGAAATTGAGAAGCTGTCCACGCTGTCATGGTTCACG
GTGGAGTTCGGGCTGTGTAAGCAGAACGGGGAGGTGAAGGCCTATGGTGCCGGGCTGCTG
TCCTCCTACGGGGAGCTCCTGCACTGCCTGTCTGAGGAGCCTGAGATTCGGGCCTTCGAC
CCTGAGGCTGCGGCCGTGCAGCCCTACCAAGACCAGACGTACCAGTCAGTCTACTTCGTG
TCTGAGAGCTTCAGTGACGCCAAGGACAAGCTCAGGAGCTATGCCTCACGCATCCAGCGC
CCCTTCTCCGTGAAGTTCGACCCGTACACGCTGGCCATCGACGTGCTGGACAGCCCCCAG
GCCGTGCGGCGCTCCCTGGAGGGTGTCCAGGATGAGCTGGACACCCTTGCCCATGCGCTG
AGTGCCATTGGCTAG

# Macromolecular_Interacting_Partner_32_GenBank_ID_Gene:
Y00414

# Macromolecular_Interacting_Partner_32_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_32_Locus:
11p15.5

# Macromolecular_Interacting_Partner_32_SNPs:
rs6356; rs7950050; rs6357; rs34510659; rs11826260; rs3842725; rs10840489; rs11825601; rs4074905; rs12419447; rs2070762; rs7482510; rs3842722; rs7925924; rs7942881; rs11826130; rs7483805; rs7483056; rs4072826; rs4072824; rs7925375; rs7479936; rs4072823; rs3842723; rs10743149; rs10770140; rs3842727; rs7119275; rs7115640; rs10840490; rs10770141; rs11564711; rs10840491; rs3842726; rs11042962; rs10770142; rs28934581; rs28934579; rs28934580; rs1800033; rs36097848; rs3842724; rs1799833; rs11564716; rs34723540; rs6578990; rs11042950; rs3842721; rs35596265; rs11564713; rs11564712; rs36009557; rs4930043; rs36010304; rs7925784; rs35996457; rs4072825; rs35125951; rs11564714; rs35444567; rs34965351; rs11564715; rs11564717; rs10734659; rs11564718; rs1800032; rs10743152; rs10770143; rs10840447; rs10840452; rs10840495; rs10840496; rs10840502; rs11042965; rs11042966; rs11042971; rs11042976; rs11042978; rs11042982; rs11042984; rs11042987; rs11564709; rs11564710; rs11564720; rs2000993; rs28494588; rs28933985; rs3842733; rs3842738; rs3842741; rs3842748; rs3842752; rs3842753; rs3842754; rs3842756; rs3842768; rs3842769; rs3842770; rs3842775; rs4929964; rs4929966; rs4930046; rs5505; rs5506; rs5507; rs6578993; rs689; rs7110099; rs7128097; rs7482891; rs7936868

# Macromolecular_Interacting_Partner_32_General_References:
2882428; 2888085; 2887169; 2902075; 2892893; 2896667; 7814018; 7789962; 8528210; 8817341; 9613851; 9754624; 9703425; 10391209; 11246459

# Macromolecular_Interacting_Partner_32_References:
14739357; 16165221

# Macromolecular_Interacting_Partner_33_ID:
8381

# Macromolecular_Interacting_Partner_33_Name:
Myc proto-oncogene protein

# Macromolecular_Interacting_Partner_33_Synonyms:
c-Myc; Transcription factor p64

# Macromolecular_Interacting_Partner_33_Gene_Name:
MYC

# Macromolecular_Interacting_Partner_33_Protein_Sequence:
>Myc protooncogene protein
MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPP
LSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD
DETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQD
LSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVL
HEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRC
HVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHN
VLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLL
RKRREQLKHKLEQLRNSCA

# Macromolecular_Interacting_Partner_33_Number_of_Residues:
439

# Macromolecular_Interacting_Partner_33_Molecular_Weight:
48804

# Macromolecular_Interacting_Partner_33_Theoretical_pI:
5.16

# Macromolecular_Interacting_Partner_33_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
Function:  transcription regulator activity
 ||
>>>
Process:  regulation of transcription, DNA-dependent
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_33_General_Function:
Not Available

# Macromolecular_Interacting_Partner_33_Specific_Function:
Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes

# Macromolecular_Interacting_Partner_33_Pathway:
Not Available

# Macromolecular_Interacting_Partner_33_Reaction:
Not Available

# Macromolecular_Interacting_Partner_33_Pfam_Domain_Function:
PF00010:HLH;
PF02344:Myc-LZ;
PF01056:Myc_N

# Macromolecular_Interacting_Partner_33_Signals:
None

# Macromolecular_Interacting_Partner_33_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_33_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_33_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_33_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_33_SwissProt_ID:
MYC_HUMAN (P01106)

# Macromolecular_Interacting_Partner_33_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_33_Genecard_id:
MYC

# Macromolecular_Interacting_Partner_33_Geneatlas_id:
MYC

# Macromolecular_Interacting_Partner_33_hgnc_id:
HGNC:7553

# Macromolecular_Interacting_Partner_33_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_33_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_33_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_33_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_33_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_33_GenBank_ID_Gene:
D10493

# Macromolecular_Interacting_Partner_33_Chromosome_Location:
Chromosome:8

# Macromolecular_Interacting_Partner_33_Locus:
8q24.12-q24.13

# Macromolecular_Interacting_Partner_33_SNPs:
rs4645961; rs4645959; rs4645968; rs4645960; rs4645969; rs2070582; rs2070583; rs4645970; rs35524866; rs4645955; rs3891248; rs4645966; rs4645962; rs4645956; rs4645958; rs4645967; rs10110283; rs4645963; rs4645957; rs4645954; rs28933407; rs14607; rs34219247; rs35291508; rs4645953; rs35168393; rs35015903; rs4645964; rs4645965; rs35084990; rs10706841; rs10706840; rs5894898; rs34682115; rs4645971; rs35631115; rs10108288; rs10505505; rs10956383; rs11782002; rs12680047; rs16902359; rs16902364; rs16902387; rs17187428; rs17773712; rs2071346; rs3808379; rs3824120; rs3895617; rs4645940; rs4645941; rs4645943; rs4645945; rs4645946; rs4645947; rs4645948; rs4645950; rs4645951; rs4645972; rs4645973; rs4645974; rs4645975; rs4733550; rs7003472; rs7013527; rs7462301; rs7818443

# Macromolecular_Interacting_Partner_33_General_References:
6714223; 6298632; 6304538; 6321164; 6419122; 6414718; 6304729; 6547209; 3540591; 8386367; 7642555; 9315742; 9680483

# Macromolecular_Interacting_Partner_33_References:
14568568; 15713675

# Macromolecular_Interacting_Partner_34_ID:
8444

# Macromolecular_Interacting_Partner_34_Name:
Transforming growth factor beta-1 precursor

# Macromolecular_Interacting_Partner_34_Synonyms:
TGF-beta-1[Contains: Latency-associated peptide; LAP]

# Macromolecular_Interacting_Partner_34_Gene_Name:
TGFB1

# Macromolecular_Interacting_Partner_34_Protein_Sequence:
>Transforming growth factor beta1 precursor
MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI
YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR
YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT
TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI
DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA
LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

# Macromolecular_Interacting_Partner_34_Number_of_Residues:
390

# Macromolecular_Interacting_Partner_34_Molecular_Weight:
44342

# Macromolecular_Interacting_Partner_34_Theoretical_pI:
8.63

# Macromolecular_Interacting_Partner_34_GO_Classification:
>>>
Function:  growth factor activity
Function:  signal transducer activity
Function:  receptor binding
Function:  transforming growth factor beta receptor binding
 ||
>>>
Process:  growth
Process:  cell growth
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_34_General_Function:
Not Available

# Macromolecular_Interacting_Partner_34_Specific_Function:
Multifunctional protein that control proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGFB1 and essentially all of them have specific receptors for this protein. It regulates the actions of many other growth factors and determines a positive or negative direction of their effects. It plays an important role in bone remodelling. It is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts

# Macromolecular_Interacting_Partner_34_Pathway:
Not Available

# Macromolecular_Interacting_Partner_34_Reaction:
Not Available

# Macromolecular_Interacting_Partner_34_Pfam_Domain_Function:
PF00019:TGF_beta;
PF00688:TGFb_propeptide

# Macromolecular_Interacting_Partner_34_Signals:
1-29

# Macromolecular_Interacting_Partner_34_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_34_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_34_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_34_GenBank_ID_Protein:
1212989

# Macromolecular_Interacting_Partner_34_SwissProt_ID:
TGFB1_HUMAN (P01137)

# Macromolecular_Interacting_Partner_34_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_34_Genecard_id:
TGFB1

# Macromolecular_Interacting_Partner_34_Geneatlas_id:
TGFB1

# Macromolecular_Interacting_Partner_34_hgnc_id:
HGNC:11766

# Macromolecular_Interacting_Partner_34_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_34_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_34_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_34_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_34_Gene_Sequence:
>355 bp
ATGCCGCCCTCCGGGCTGCGGCTGCTGCTGCTGCTGCTACCGCTGCTGTGGCTACTGGTG
CTGACGCCTGGCCGGCCGGCCGCGGGACTATCCACCTGCAAGACTATCGACATGGAGCTG
GTGAAGCGGAAGCGCATCGAGGCCATCCGCGGCCAGATCCTGTCCAAGCTGCGGCTCGCC
AGCCCCCCGAGCCAGGGGGAGGTGCCGCCCGGCCCGCTGCCCGAGGCCGTGCTCGCCCTG
TACAACAGCACCCGCGACCGGGTGGCCGGGGAGAGTGCAGAACCGGAGCCCGAGCCTGAG
GCCGACTACTACGCCAAGGAGGTCACCCGCGTGCTAATGGTGGAAACCCACAACG

# Macromolecular_Interacting_Partner_34_GenBank_ID_Gene:
X05839

# Macromolecular_Interacting_Partner_34_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_34_Locus:
19q13.2|19q13.1

# Macromolecular_Interacting_Partner_34_SNPs:
rs1982073; rs1800472; rs1800471; rs9282871; rs11466316; rs11466315; rs2241717; rs7408955; rs2278422; rs13306709; rs7258445; rs2288873; rs747857; rs8110090; rs11466329; rs2288874; rs11466347; rs2241716; rs8179181; rs8102501; rs11466345; rs8105161; rs6508976; rs4803455; rs1989457; rs11466338; rs10405403; rs8108052; rs2241715; rs11466335; rs11466357; rs12461895; rs6508975; rs11466337; rs11466351; rs11466344; rs12462166; rs11466331; rs11466341; rs11466324; rs11466359; rs11466318; rs10420084; rs11466356; rs11466343; rs11466321; rs1549934; rs10406816; rs11466334; rs11466349; rs10416269; rs11466353; rs8179182; rs13447341; rs35383147; rs11466358; rs11551225; rs11551223; rs12977601; rs12985978; rs13306707; rs11551226; rs36102838; rs13306706; rs35025994; rs12977628; rs13306708; rs11466354; rs11466330; rs7249191; rs35169655; rs11466327; rs11466355; rs8102918; rs9749548; rs12983775; rs5828100; rs3061187; rs41275752; rs12979815; rs35276753; rs35019416; rs3061188; rs2288875; rs3061192; rs5828102; rs28730295; rs12976890; rs35312206; rs11466333; rs33950017; rs11403932; rs11466340; rs11331966; rs3061190; rs2014015; rs11466328; rs11672143; rs35976994; rs5828101; rs11466346; rs10418010; rs8108632; rs35676663; rs35197353; rs11466352; rs11307639; rs11347492; rs12980944; rs11367425; rs36050346; rs34368921; rs8103575; rs11466350; rs11466342; rs12978333; rs11466320; rs11466348; rs41333448; rs34971127; rs11673275; rs11466336; rs28769597; rs11466339; rs5828099; rs10406316; rs12976219; rs34233206; rs10417924; rs1054797; rs11083616; rs11304; rs11668109; rs11668308; rs11669342; rs11879777; rs12980298; rs12980942; rs12981053; rs12983047; rs16959007; rs1800468; rs1800469; rs1800820; rs1982072; rs2241712; rs2241713; rs2241714; rs2241718; rs2241719; rs2241720; rs34088631; rs35135271; rs3810173; rs4803454; rs6957; rs7257310; rs7257742

# Macromolecular_Interacting_Partner_34_General_References:
3470709; 3861940; 8471846; 2982829; 3162913; 9150447; 11746498; 8424942; 8424943; 8679613; 9783545; 10973241; 11062463; 12202987; 12493741; 12843182

# Macromolecular_Interacting_Partner_34_References:
12823590; 14594506; 16408114; 16632996

# Macromolecular_Interacting_Partner_35_ID:
8353

# Macromolecular_Interacting_Partner_35_Name:
Heat-shock protein beta-1

# Macromolecular_Interacting_Partner_35_Synonyms:
HspB1; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein

# Macromolecular_Interacting_Partner_35_Gene_Name:
HSPB1

# Macromolecular_Interacting_Partner_35_Protein_Sequence:
>Heatshock protein beta1
MTERRVPFSLLRGPSWDPFRDWYPHSRLFDQAFGLPRLPEEWSQWLGGSSWPGYVRPLPP
AAIESPAVAAPAYSRALSRQLSSGVSEIRHTADRWRVSLDVNHFAPDELTVKTKDGVVEI
TGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMPKLATQSNEIT
IPVTFESRAQLGGPEAAKSDETAAK

# Macromolecular_Interacting_Partner_35_Number_of_Residues:
205

# Macromolecular_Interacting_Partner_35_Molecular_Weight:
22783

# Macromolecular_Interacting_Partner_35_Theoretical_pI:
6.36

# Macromolecular_Interacting_Partner_35_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_35_General_Function:
Not Available

# Macromolecular_Interacting_Partner_35_Specific_Function:
Involved in stress resistance and actin organization

# Macromolecular_Interacting_Partner_35_Pathway:
Not Available

# Macromolecular_Interacting_Partner_35_Reaction:
Not Available

# Macromolecular_Interacting_Partner_35_Pfam_Domain_Function:
PF00011:HSP20

# Macromolecular_Interacting_Partner_35_Signals:
None

# Macromolecular_Interacting_Partner_35_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_35_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_35_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_35_GenBank_ID_Protein:
662841

# Macromolecular_Interacting_Partner_35_SwissProt_ID:
HSPB1_HUMAN (P04792)

# Macromolecular_Interacting_Partner_35_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_35_Genecard_id:
HSPB1

# Macromolecular_Interacting_Partner_35_Geneatlas_id:
HSPB1

# Macromolecular_Interacting_Partner_35_hgnc_id:
HGNC:5246

# Macromolecular_Interacting_Partner_35_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_35_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_35_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_35_Subcellular_Location:
Cytoplasm. Nucleus. Note=Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock

# Macromolecular_Interacting_Partner_35_Gene_Sequence:
>600 bp
ATGACCGAGCGCCGCGTCCCCTTCTCGCTCCTGCGGGGCCCCAGCTGGGACCCCTTCCGC
GACTGGTACCCGCATAGCCGCCTCTTCGACCAGGCCTTCGGGCTGCCCCGGCTGCCGGAG
GAGTGGTCGCAGTGGTTAGGCGGCAGCAGCTGGCCAGGCTACGTGCGCCCCCTGCCCCCC
GCCGCCATCGAGAGCCCCGCAGTGGCCGCGCCCGCCTACAGCCGCGCGCTCAGCCGGCAA
CTCAGCAGCGGGGTCTCGGAGATCCGGCACACTGCGGACCGCTGGCGCGTGTCCCTGGAT
GTCAACCACTTCGCCCCGGACGAGCTGACGGTCAAGACCAAGGATGGCGTGGTGGAGATC
ACCGGCAAGCACGAGGAGCGGCAGGACGAGCATGGCTACATCTCCCGGTGCTTCACGCGG
AAATACACGCTGCCCCCCGGTGTGGACCCCACCCAAGTTTCCTCCTCCCTGTCCCCTGAG
GGCACACTGACCGTGGAGGCCCCCATGCCCAAGCTAGCCACGCAGTCCAACGAGATCACC
ATCCCAGTCACCTTCGAGTCGCGGGCCCAGCTTGGGGGCAGAAGCTGCAAAATCCGATGA


# Macromolecular_Interacting_Partner_35_GenBank_ID_Gene:
L39370

# Macromolecular_Interacting_Partner_35_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_35_Locus:
7q11.23

# Macromolecular_Interacting_Partner_35_SNPs:
rs7805625; rs35907174; rs7804492; rs28708645; rs34957294; rs11769502; rs34429571; rs2868371; rs6963310; rs2070804; rs34484713; rs2868370; rs2903814; rs2908199; rs2903813; rs34428939; rs2009836; rs2908198; rs10252296; rs1049850; rs17850892; rs28937568; rs11547167; rs17850893; rs11547165; rs1049324; rs11547163; rs1049345; rs28937569; rs11547168; rs3190199; rs11547166; rs11547164; rs1804841; rs34771861; rs6150170; rs3842186; rs35759978; rs1058872; rs33964165; rs3199775; rs1059692; rs6967273; rs11435582; rs36112129; rs36073761; rs36071791; rs35993682; rs35758543; rs2868372; rs3081056; rs35233076; rs34156885; rs7457776; rs3081054; rs35423129; rs35485732; rs34014633; rs35408134; rs10277170; rs10488574; rs1076436; rs11975763; rs11977849; rs11978285; rs11980593; rs12532935; rs12533836; rs17210045; rs2908201; rs2908203; rs7459185; rs757626

# Macromolecular_Interacting_Partner_35_General_References:
3714473; 2243808; 10777697; 9110174; 12853948; 2743305; 1763035; 2295696; 8325890; 10751411

# Macromolecular_Interacting_Partner_35_References:
16469826

# Macromolecular_Interacting_Partner_36_ID:
7867

# Macromolecular_Interacting_Partner_36_Name:
Interleukin-8 precursor

# Macromolecular_Interacting_Partner_36_Synonyms:
IL-8; CXCL8; Monocyte-derived neutrophil chemotactic factor; MDNCF; T-cell chemotactic factor; Neutrophil- activating protein 1; NAP-1; Protein 3-10C; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil-activating peptide; MONAP; Emoctakin[Contains: MDNCF-a; IL8/NAP1 form I; GCP/IL-8 protein IV; Interleukin-8; IL-8(1-77; MDNCF-b; IL8/NAP1 form II; GCP/IL-8 protein II; (Ala-IL-877; IL-8(5-77; IL-8(6-77; Lymphocyte-derived neutrophil-activating factor; LYNAP; Neutrophil- activating factor; NAF; MDNCF-c; IL8/NAP1 form III; GCP/IL-8 protein I; (Ser-IL-872; IL-8(7-77; IL8/NAP1 form IV; GCP/IL-8 protein V; IL-8(8-77; IL8/NAP1 form V; GCP/IL-8 protein VI; IL- 8(9-77; IL8/NAP1 form VI; GCP/IL-8 protein III]

# Macromolecular_Interacting_Partner_36_Gene_Name:
IL8

# Macromolecular_Interacting_Partner_36_Protein_Sequence:
>Interleukin8 precursor
MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPH
CANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS

# Macromolecular_Interacting_Partner_36_Number_of_Residues:
99

# Macromolecular_Interacting_Partner_36_Molecular_Weight:
11098

# Macromolecular_Interacting_Partner_36_Theoretical_pI:
9.09

# Macromolecular_Interacting_Partner_36_GO_Classification:
>>>
Function:  chemokine activity
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_36_General_Function:
Not Available

# Macromolecular_Interacting_Partner_36_Specific_Function:
IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively

# Macromolecular_Interacting_Partner_36_Pathway:
Not Available

# Macromolecular_Interacting_Partner_36_Reaction:
Not Available

# Macromolecular_Interacting_Partner_36_Pfam_Domain_Function:
PF00048:IL8

# Macromolecular_Interacting_Partner_36_Signals:
1-20

# Macromolecular_Interacting_Partner_36_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_36_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_36_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_36_GenBank_ID_Protein:
34519

# Macromolecular_Interacting_Partner_36_SwissProt_ID:
IL8_HUMAN (P10145)

# Macromolecular_Interacting_Partner_36_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_36_Genecard_id:
IL8

# Macromolecular_Interacting_Partner_36_Geneatlas_id:
IL8

# Macromolecular_Interacting_Partner_36_hgnc_id:
HGNC:6025

# Macromolecular_Interacting_Partner_36_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_36_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_36_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_36_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_36_Gene_Sequence:
>300 bp
ATGACTTCCAAGCTGGCCGTGGCTCTCTTGGCAGCCTTCCTGATTTCTGCAGCTCTGTGT
GAAGGTGCAGTTTTGCCAAGGAGTGCTAAAGAACTTAGATGTCAGTGCATAAAGACATAC
TCCAAACCTTTCCACCCCAAATTTATCAAAGAACTGAGAGTGATTGAGAGTGGACCACAC
TGCGCCAACACAGAAATTATTGTAAAGCTTTCTGATGGAAGAGAGCTCTGTCTGGACCCC
AAGGAAAACTGGGTGCAGAGGGTTGTGGAGAAGTTTTTGAAGAGGGCTGAGAATTCATAA


# Macromolecular_Interacting_Partner_36_GenBank_ID_Gene:
Y00787

# Macromolecular_Interacting_Partner_36_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_36_Locus:
4q13-q21

# Macromolecular_Interacting_Partner_36_SNPs:
rs1803205; rs1126647; rs2227537; rs2227538; rs34915905; rs2227545; rs2227546; rs12420; rs11733933; rs2227540; rs2227549; rs2227307; rs2227543; rs2227306; rs2227541; rs2227542; rs2227539; rs2227532; rs2227528; rs2227534; rs4073; rs2227531; rs7682639; rs2227527; rs2227544; rs3181685; rs35607711; rs16849942; rs11545234; rs2227550; rs2227548; rs3756069; rs34428214; rs2227536; rs41458346; rs10938092; rs2227530; rs10719080; rs2227533; rs2227535; rs2227529; rs36078377; rs13112910; rs41505147; rs11729759; rs11730284; rs11730667; rs11940656; rs11944402; rs13106097; rs13142454; rs16849925; rs16849928; rs16849934; rs16849958; rs17202249; rs1951236; rs1951237; rs1951239; rs1951240; rs1951242; rs1951699; rs1951700; rs1957661; rs2227517; rs2227518; rs2227524; rs2227525; rs2227526; rs4694178; rs4694635; rs4694636; rs4694637; rs7658422; rs7674884

# Macromolecular_Interacting_Partner_36_General_References:
3260265; 2953813; 2664463; 2663993; 2648135; 2655583; 2659722; 3279957; 3322281; 3480540; 2145175; 2523801; 2212672; 2007144; 11023497; 1639201; 2681204; 2184886; 8631339; 10368283; 2182630; 2005614; 1988949; 10707023

# Macromolecular_Interacting_Partner_36_References:
12608468; 15958071

# Macromolecular_Interacting_Partner_37_ID:
7936

# Macromolecular_Interacting_Partner_37_Name:
Apoptosis regulator Bcl-2

# Macromolecular_Interacting_Partner_37_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_37_Gene_Name:
BCL2

# Macromolecular_Interacting_Partner_37_Protein_Sequence:
>Apoptosis regulator Bcl2
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK

# Macromolecular_Interacting_Partner_37_Number_of_Residues:
239

# Macromolecular_Interacting_Partner_37_Molecular_Weight:
26266

# Macromolecular_Interacting_Partner_37_Theoretical_pI:
7.32

# Macromolecular_Interacting_Partner_37_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of cellular physiological process
Process:  regulation of programmed cell death
Process:  regulation of apoptosis
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_37_General_Function:
Not Available

# Macromolecular_Interacting_Partner_37_Specific_Function:
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)

# Macromolecular_Interacting_Partner_37_Pathway:
Not Available

# Macromolecular_Interacting_Partner_37_Reaction:
Not Available

# Macromolecular_Interacting_Partner_37_Pfam_Domain_Function:
PF00452:Bcl-2;
PF02180:BH4

# Macromolecular_Interacting_Partner_37_Signals:
None

# Macromolecular_Interacting_Partner_37_Transmembrane_Regions:
212-233

# Macromolecular_Interacting_Partner_37_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_37_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_37_GenBank_ID_Protein:
179367

# Macromolecular_Interacting_Partner_37_SwissProt_ID:
BCL2_HUMAN (P10415)

# Macromolecular_Interacting_Partner_37_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_37_Genecard_id:
BCL2

# Macromolecular_Interacting_Partner_37_Geneatlas_id:
BCL2

# Macromolecular_Interacting_Partner_37_hgnc_id:
HGNC:990

# Macromolecular_Interacting_Partner_37_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_37_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_37_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_37_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass membrane protein. Nucleus; nuclear membrane; single- pass membrane protein. Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein

# Macromolecular_Interacting_Partner_37_Gene_Sequence:
>720 bp
ATGGCGCACGCTGGGAGAACGGGGTACGACAACCGGGAGATAGTGATGAAGTACATCCAT
TATAAGCTGTCGCAGAGGGGCTACGAGTGGGATGCGGGAGATGTGGGCGCCGCGCCCCCG
GGGGCCGCCCCCGCACCGGGCATCTTCTCCTCCCAGCCCGGGCACACGCCCCATCCAGCC
GCATCCCGCGACCCGGTCGCCAGGACCTCGCCGCTGCAGACCCCGGCTGCCCCCGGCGCC
GCCGCGGGGCCTGCGCTCAGCCCGGTGCCACCTGTGGTCCACCTGGCCCTCCGCCAAGCC
GGCGACGACTTCTCCCGCCGCTACCGCGGCGACTTCGCCGAGATGTCCAGCCAGCTGCAC
CTGACGCCCTTCACCGCGCGGGGACGCTTTGCCACGGTGGTGGAGGAGCTCTTCAGGGAC
GGGGTGAACTGGGGGAGGATTGTGGCCTTCTTTGAGTTCGGTGGGGTCATGTGTGTGGAG
AGCGTCAACCGGGAGATGTCGCCCCTGGTGGACAACATCGCCCTGTGGATGACTGAGTAC
CTGAACCGGCACCTGCACACCTGGATCCAGGATAACGGAGGCTGGGATGCCTTTGTGGAA
CTGTACGGCCCCAGCATGCGGCCTCTGTTTGATTTCTCCTGGCTGTCTCTGAAGACTCTG
CTCAGTTTGGCCCTGGTGGGAGCTTGCATCACCCTGGGTGCCTATCTGAGCCACAAGTGA


# Macromolecular_Interacting_Partner_37_GenBank_ID_Gene:
M13994

# Macromolecular_Interacting_Partner_37_Chromosome_Location:
Chromosome:18

# Macromolecular_Interacting_Partner_37_Locus:
18q21.33|18q21.3

# Macromolecular_Interacting_Partner_37_SNPs:
rs1800477; rs1801018; rs1564483; rs1016860; rs4987853; rs4987861; rs4987843; rs4987852; rs3744935; rs4987864; rs4987856; rs4987854; rs4987855; rs4987846; rs4987851; rs4987858; rs4987850; rs4987859; rs4987865; rs4987845; rs4987869; rs3744937; rs4987847; rs1473418; rs4987867; rs720321; rs1383596; rs1944419; rs1531697; rs2046136; rs1545812; rs1481031; rs2332673; rs726510; rs899968; rs2062011; rs2850763; rs1381548; rs949037; rs2156192; rs2850761; rs7226979; rs1009726; rs4940576; rs2850762; rs6567334; rs2551397; rs2849377; rs2199937; rs4987792; rs11872403; rs11152377; rs4941195; rs4941183; rs2156190; rs2062010; rs8094489; rs11152375; rs12606418; rs8083946; rs726511; rs3810027; rs1542578; rs8094651; rs1462129; rs4941189; rs4941192; rs3810031; rs3943258; rs8088662; rs8096380; rs4940573; rs7228914; rs11661511; rs7240326; rs2156193; rs8086404; rs6567336; rs2849381; rs8094315; rs11876772; rs4987790; rs11152370; rs4987752; rs4940575; rs4456611; rs1893506; rs2046135; rs12457700; rs8088100; rs7242402; rs11661497; rs4940572; rs1944420; rs9955190; rs1944422; rs12454650; rs1977971; rs8089331; rs2850758; rs2046137; rs1573493; rs8084922; rs8089538; rs4987802; rs6567328; rs8095050; rs2156191; rs2849380; rs1481032; rs11875184; rs1807999; rs9807663; rs4940574; rs7230053; rs1982674; rs12457170; rs4941188; rs1344229; rs7234941; rs6567327; rs11152374; rs11152372; rs9965844; rs6567326; rs7239838; rs9962222; rs9959874; rs4940571; rs2187162; rs4987819; rs2051423; rs3810028; rs899966; rs4987739; rs6567329; rs4941185; rs4987718; rs10503079; rs8098548; rs3744933; rs3744948; rs17070798; rs4987760; rs8098848; rs4987788; rs7243201; rs4941187; rs12968517; rs4987772; rs4987722; rs4987803; rs731014; rs3744951; rs1982673; rs4987736; rs17070904; rs6567330; rs11659758; rs2850760; rs9967405; rs8099575; rs17757981; rs9630855; rs4987786; rs12454712; rs12457893; rs4987724; rs8099140; rs12970840; rs4987778; rs4987831; rs4987829; rs1026825; rs12458289; rs9972995; rs10503077; rs6567325; rs4987823; rs4987765; rs4987726; rs4987757; rs11152371; rs12605881; rs4987746; rs11875971; rs4987827; rs12961976; rs4987795; rs4987797; rs899965; rs7244617; rs1531695; rs9962656; rs12457831; rs11872329; rs4987838; rs4941184; rs2051424; rs2615200; rs7242542; rs8094630; rs7236090; rs6567324; rs7231914; rs1893806; rs4987768; rs17070959; rs1005793; rs8085707; rs17070739; rs11875686; rs17679032; rs4987721; rs4987808; rs765102; rs8097624; rs3744950; rs4987801; rs1009725; rs6567335; rs17070848; rs17685559; rs956572; rs12961672; rs11663275; rs744569; rs4987764; rs12457190; rs4941186; rs17070861; rs4941194; rs4987835; rs2170294; rs4987755; rs6567331; rs4987841; rs4987737; rs9959983; rs768058; rs7243091; rs8095077; rs4987725; rs4987733; rs17756073; rs11877475; rs8093973; rs4987839; rs4987759; rs4987783; rs960804; rs4987743; rs4987779; rs10503078; rs17757541; rs899964; rs7230970; rs4987716; rs7232625; rs9951943; rs9958550; rs8092560; rs4941190; rs12457371; rs4987828; rs3826622; rs8096471; rs8083727; rs4987821; rs2849382; rs9962051; rs17756365; rs17070913; rs8087120; rs2170295; rs4987810; rs6567332; rs899967; rs4987774; rs1381546; rs10460157; rs11873429; rs4987826; rs4987798; rs1473435; rs7242904; rs4987809; rs7242501; rs4987800; rs7232512; rs12957119; rs10164240; rs4987742; rs3948977; rs4987719; rs12458944; rs4987796; rs7231901; rs17678177; rs8099218; rs2551399; rs4987770; rs4987825; rs17070714; rs4987781; rs12962644; rs4987812; rs12963263; rs4987834; rs4987747; rs4987767; rs17758695; rs9963148; rs17841945; rs4987744; rs9959769; rs12457361; rs9946649; rs4987794; rs11152373; rs11872297; rs17070779; rs4987728; rs12963776; rs12958785; rs17686373; rs1976005; rs12457841; rs8092884; rs7240319; rs9946637; rs9961642; rs17759096; rs11877911; rs4987773; rs1944421; rs2170296; rs11877925; rs9961796; rs7230177; rs4987715; rs4987732; rs17070777; rs11874082; rs9965829; rs4987761; rs17758456; rs17062654; rs4987789; rs4987771; rs17070827; rs17758816; rs7232082; rs11661184; rs12962650; rs3842401; rs8098586; rs17678294; rs17677569; rs17070818; rs954954; rs9957149; rs1541298; rs4987717; rs9962421; rs17070841; rs4987730; rs8097918; rs8089306; rs12967026; rs7236202; rs4987750; rs17685987; rs2840358; rs4987787; rs4987780; rs17841946; rs4987723; rs7237139; rs1481030; rs12454618; rs12968867; rs9966563; rs17070877; rs17070809; rs9958905; rs6567333; rs3810030; rs4987741; rs12964150; rs9972996; rs7245234; rs1381547; rs17756248; rs4987807; rs12604822; rs17070735; rs17756266; rs4987824; rs12456572; rs2850755; rs17070943; rs4987749; rs17070946; rs17759659; rs12605858; rs4987791; rs4987815; rs9962963; rs3927911; rs8091529; rs4987822; rs8085473; rs4987731; rs17758403; rs4987745; rs4987818; rs9965425; rs4987793; rs1541295; rs4987832; rs12455492; rs4987720; rs4987817; rs2849379; rs17070750; rs4987830; rs4987873; rs2448799; rs8087606; rs4987872; rs2279115; rs41301945; rs5825508; rs2078303; rs4987849; rs17070680; rs41306972; rs34741396; rs4987866; rs34360708; rs34883036; rs1050618; rs34811186; rs4987707; rs4987868; rs4987844; rs4987862; rs34223591; rs4987842; rs4987870; rs4987848; rs4987710; rs4987860; rs34143126; rs4987706; rs3744936; rs4987863; rs4987857; rs11351478; rs35558540; rs36046351; rs34986306; rs11384331; rs12327138; rs34592237; rs34479040; rs35443488; rs35735146; rs4987738; rs35954402; rs9953797; rs11286497; rs34714510; rs34470267; rs2127872; rs34356346; rs10597397; rs7230110; rs5825509; rs4987769; rs11346802; rs35765197; rs35992365; rs28744646; rs35421280; rs7242051; rs7230703; rs3216124; rs11878084; rs3833192; rs9320014; rs34032861; rs10536242; rs28613776; rs35702853; rs35957660; rs11877270; rs36089071; rs11411155; rs34999271; rs28603232; rs8099362; rs11424742; rs34128466; rs4987740; rs36230193; rs35775563; rs34585115; rs9944895; rs4987754; rs34926393; rs35844118; rs4987753; rs4987763; rs9949240; rs4987751; rs7242531; rs11421019; rs28669125; rs28550381; rs28502762; rs28662060; rs34092929; rs28702921; rs35942763; rs35275357; rs35195646; rs2332672; rs7232179; rs11381388; rs34385891; rs34140806; rs28460613; rs2187163; rs35366804; rs28699603; rs4384687; rs35180138; rs12958555; rs4987713; rs4987805; rs35063180; rs28564323; rs9959358; rs4987837; rs596876; rs4987799; rs4987814; rs34360704; rs34927632; rs36074022; rs7232529; rs4987840; rs4987813; rs34603960; rs34737549; rs34810572; rs4987782; rs12956558; rs34724235; rs35832816; rs11396022; rs4987734; rs35916533; rs11426842; rs34422779; rs35788320; rs7243686; rs34269955; rs34821656; rs34331087; rs4987735; rs2615199; rs7245040; rs28537871; rs34628711; rs34530559; rs34280008; rs9946231; rs34246997; rs35618914; rs7504762; rs11285614; rs9955851; rs4987784; rs12454033; rs35117243; rs4987833; rs35832711; rs11876939; rs4987711; rs2085958; rs4987776; rs4987816; rs11271834; rs9807796; rs34929825; rs2849378; rs34498028; rs8094130; rs34272291; rs8089583; rs5825512; rs35786465; rs11437030; rs3810029; rs10560567; rs34392530; rs11875445; rs36010160; rs33935449; rs1870863; rs11874495; rs28566629; rs35829205; rs10604257; rs12327294; rs4987758; rs11407054; rs34122166; rs35501583; rs12454460; rs34597011; rs34215080; rs11664592; rs11330056; rs11348997; rs4987762; rs11346034; rs641060; rs35852603; rs34970907; rs7238198; rs35043985; rs10640757; rs35621103; rs34019962; rs4987820; rs11333396; rs12326606; rs11269260; rs36107927; rs34843082; rs35457535; rs12969008; rs10564352; rs4987748; rs35869219; rs1273018; rs28417258; rs17070962; rs34520768; rs34167266; rs34372247; rs34877412; rs1138828; rs12962685; rs12955832; rs28588396; rs12958518; rs33983598; rs4411604; rs2849374; rs8089784; rs1679896; rs12956104; rs35051109; rs28552905; rs3744949; rs34724758; rs7230557; rs4987811; rs34616260; rs34660120; rs34455531; rs7231840; rs4987766; rs11343409; rs11377778; rs11282101; rs11663364; rs12327297; rs12957272; rs34096346; rs12954887; rs35880134; rs8097683; rs7245041; rs11152376; rs11307145; rs11389759; rs34302549; rs35608542; rs34601248; rs35378587; rs34971240; rs7239903; rs4987727; rs34857794; rs34026129; rs36077676; rs34008827; rs11289698; rs28552745; rs35997590; rs36078664; rs10688243; rs35024611; rs35764546; rs34513836; rs34355655; rs720849; rs10718817; rs36027128; rs8092584; rs4987756; rs35555671; rs7242090; rs35771638; rs1789627; rs1271892; rs7236823; rs4987785; rs4987714; rs1462128; rs35032484; rs12605689; rs7239542; rs4941193; rs10537349; rs12970504; rs10642228; rs35689542; rs11393921; rs12962313; rs4987836; rs36095867; rs35696527; rs34059678; rs35046846; rs34022610; rs5825511; rs35369252; rs34870728; rs34960660; rs7244494; rs36099507; rs35770276; rs35956166; rs12964435; rs28562101; rs34051656; rs11271898; rs4987804; rs4987729; rs7231259; rs35818172; rs34831717; rs28464692; rs4987777; rs34298527; rs7504665; rs35161404; rs5825510; rs35593106; rs35291046; rs7230565; rs34430054; rs8098774; rs34875078; rs34683668; rs28484798; rs1531696; rs34596364; rs11399943; rs4987712; rs28431965; rs765479; rs34457708; rs36088248; rs12958359; rs2516293; rs34174534; rs35525138; rs2551400; rs35834230; rs4987705; rs4987871; rs2448798; rs2472571; rs35953169; rs34619379; rs10460159; rs11660715; rs17070659; rs17676919; rs17676949; rs17749561; rs1944423; rs2051422; rs2448800; rs2448804; rs2448805; rs2448806; rs2472572; rs2472574; rs2472576; rs2472577; rs2472578; rs2472579; rs2472581; rs2551402; rs2551404; rs2551405; rs2850764; rs698708; rs7243985; rs8086644; rs8094041; rs8099294; rs9320013; rs9945794; rs9957746; rs9989529

# Macromolecular_Interacting_Partner_37_General_References:
3523487; 1508712; 2875799; 2834197; 3285301; 1339299; 2250705; 8183370; 9395403; 8668206; 11368354; 10567572; 11463391; 12901880

# Macromolecular_Interacting_Partner_37_References:
12974082; 15934930

# Macromolecular_Interacting_Partner_38_ID:
8170

# Macromolecular_Interacting_Partner_38_Name:
Vascular cell adhesion protein 1 precursor

# Macromolecular_Interacting_Partner_38_Synonyms:
V-CAM 1; CD106 antigen; INCAM-100

# Macromolecular_Interacting_Partner_38_Gene_Name:
VCAM1

# Macromolecular_Interacting_Partner_38_Protein_Sequence:
>Vascular cell adhesion protein 1 precursor
MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR
TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE
IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV
TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG
SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN
RKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVR
SEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSS
VTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKA
LVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFP
APKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP
KDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQL
KDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFA
RKANMKGSYSLVEAQKSKV

# Macromolecular_Interacting_Partner_38_Number_of_Residues:
739

# Macromolecular_Interacting_Partner_38_Molecular_Weight:
81277

# Macromolecular_Interacting_Partner_38_Theoretical_pI:
4.87

# Macromolecular_Interacting_Partner_38_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular process
Process:  cell adhesion
Process:  cell-cell adhesion
 ||
>>>
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_38_General_Function:
Not Available

# Macromolecular_Interacting_Partner_38_Specific_Function:
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation

# Macromolecular_Interacting_Partner_38_Pathway:
Not Available

# Macromolecular_Interacting_Partner_38_Reaction:
Not Available

# Macromolecular_Interacting_Partner_38_Pfam_Domain_Function:
PF05790:C2-set;
PF07679:I-set;
PF00047:ig;
PF07686:V-set

# Macromolecular_Interacting_Partner_38_Signals:
1-24

# Macromolecular_Interacting_Partner_38_Transmembrane_Regions:
699-720

# Macromolecular_Interacting_Partner_38_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_38_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_38_GenBank_ID_Protein:
179886

# Macromolecular_Interacting_Partner_38_SwissProt_ID:
VCAM1_HUMAN (P19320)

# Macromolecular_Interacting_Partner_38_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_38_Genecard_id:
VCAM1

# Macromolecular_Interacting_Partner_38_Geneatlas_id:
VCAM1

# Macromolecular_Interacting_Partner_38_hgnc_id:
HGNC:12663

# Macromolecular_Interacting_Partner_38_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_38_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_38_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_38_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_38_Gene_Sequence:
>1944 bp
ATGCCTGGGAAGATGGTCGTGATCCTTGGAGCCTCAAATATACTTTGGATAATGTTTGCA
GCTTCTCAAGCTTTTAAAATCGAGACCACCCCAGAATCTAGATATCTTGCTCAGATTGGT
GACTCCGTCTCATTGACTTGCAGCACCACAGGCTGTGAGTCCCCATTTTTCTCTTGGAGA
ACCCAGATAGATAGTCCACTGAATGGGAAGGTGACGAATGAGGGGACCACATCTACGCTG
ACAATGAATCCTGTTAGTTTTGGGAACGAACACTCTTACCTGTGCACAGCAACTTGTGAA
TCTAGGAAATTGGAAAAAGGAATCCAGGTGGAGATCTACTCTTTTCCTAAGGATCCAGAG
ATTCATTTGAGTGGCCCTCTGGAGGCTGGGAAGCCGATCACAGTCAAGTGTTCAGTTGCT
GATGTATACCCATTTGACAGGCTGGAGATAGACTTACTGAAAGGAGATCATCTCATGAAG
AGTCAGGAATTTCTGGAGGATGCAGACAGGAAGTCCCTGGAAACCAAGAGTTTGGAAGTA
ACCTTTACTCCTGTCATTGAGGATATTGGAAAAGTTCTTGTTTGCCGAGCTAAATTACAC
ATTGATGAAATGGATTCTGTGCCCACAGTAAGGCAGGCTGTAAAAGAATTGCAAGTCTAC
ATATCACCCAAGAATACAGTTATTTCTGTGAATCCATCCACAAAGCTGCAAGAAGGTGGC
TCTGTGACCATGACCTGTTCCAGCGAGGGTCTACCAGCTCCAGAGATTTTCTGGAGTAAG
AAATTAGATAATGGGAATCTACAGCACCTTTCTGGAAATGCAACTCTCACCTTAATTGCT
ATGAGGATGGAAGATTCTGGAATTTATGTGTGTGAAGGAGTTAATTTGATTGGGAAAAAC
AGAAAAGAGGTGGAATTAATTGTTCAAGCATTCCCTAGAGATCCAGAAATCGAGATGAGT
GGTGGCCTCGTGAATGGGAGCTCTGTCACTGTAAGCTGCAAGGTTCCTAGCGTGTACCCC
CTTGACCGGCTGGAGATTGAATTACTTAAGGGGGAGACTATTCTGGAGAATATAGAGTTT
TTGGAGGATACGGATATGAAATCTCTAGAGAACAAAAGTTTGGAAATGACCTTCATCCCT
ACCATTGAAGATACTGGAAAAGCTCTTGTTTGTCAGGCTAAGTTACATATTGATGACATG
GAATTCGAACCCAAACAAAGGCAGAGTACGCAAACACTTTATGTCAATGTTGCCCCCAGA
GATACAACCGTCTTGGTCAGCCCTTCCTCCATCCTGGAGGAAGGCAGTTCTGTGAATATG
ACATGCTTGAGCCAGGGCTTTCCTGCTCCGAAAATCCTGTGGAGCAGGCAGCTCCCTAAC
GGGGAGCTACAGCCTCTTTCTGAGAATGCAACTCTCACCTTAATTTCTACAAAAATGGAA
GATTCTGGGGTTTATTTATGTGAAGGAATTAACCAGGCTGGAAGAAGCAGAAAGGAAGTG
GAATTAATTATCCAAGTTACTCCAAAAGACATAAAACTTACAGCTTTTCCTTCTGAGAGT
GTCAAAGAAGGAGACACTGTCATCATCTCTTGTACATGTGGAAATGTTCCAGAAACATGG
ATAATCCTGAAGAAAAAAGCGGAGACAGGAGACACAGTACTAAAATCTATAGATGGCGCC
TATACCATCCGAAAGGCCCAGTTGAAGGATGCGGGAGTATATGAATGTGAATCTAAAAAC
AAAGTTGGCTCACAATTAAGAAGTTTAACACTTGATGTTCAAGGAAGAGAAAACAACAAA
GACTATTTTTCTCCTGAGCTTCTCGTGCTCTATTTTGCATCCTCCTTAATAATACCTGCC
ATTGGAATGATAATTTACTTTGCAAGAAAAGCCAACATGAAGGGGTCATATAGTCTTGTA
GAAGCACAGAAATCAAAAGTGTAG

# Macromolecular_Interacting_Partner_38_GenBank_ID_Gene:
M30257

# Macromolecular_Interacting_Partner_38_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_38_Locus:
1p32-p31

# Macromolecular_Interacting_Partner_38_SNPs:
rs3783613; rs3783612; rs3783611; rs3783615; rs34100871; rs34228330; rs34199378; rs3176879; rs3176878; rs3783621; rs3783618; rs3783617; rs3783608; rs3783609; rs3783619; rs3783610; rs3783607; rs3176875; rs3176860; rs3176874; rs3176876; rs3917012; rs2392221; rs3181088; rs3765685; rs3819950; rs3917041; rs3176870; rs3917040; rs3176861; rs3917037; rs2209627; rs3176862; rs3917067; rs3176869; rs3917016; rs3917043; rs3917038; rs3917075; rs3917033; rs3917058; rs3917034; rs3917019; rs3917020; rs3917064; rs3917042; rs3176871; rs3176863; rs3917059; rs3917018; rs1476408; rs3176877; rs3917009; rs3917062; rs3176867; rs3917036; rs3181091; rs3917053; rs3181089; rs3917032; rs3917028; rs3917070; rs3917056; rs3917060; rs3917047; rs3917072; rs3917057; rs3917011; rs3917065; rs3917074; rs34186667; rs3917051; rs3176864; rs3917068; rs3917015; rs3917049; rs3917073; rs3917052; rs3917010; rs3176859; rs3917069; rs3917071; rs3917066; rs3917014; rs3176868; rs3917055; rs3917031; rs3917063; rs34599539; rs3917008; rs1041163; rs3181092; rs1409419; rs3917024; rs3181093; rs3170794; rs3181087; rs3783598; rs3783624; rs3783595; rs3783605; rs3917022; rs3917025; rs3783601; rs3783597; rs3917027; rs3917026; rs3783599; rs3783603; rs34708918; rs17123276; rs34682069; rs41287272; rs41402047; rs3194002; rs3783620; rs12740248; rs3917048; rs34736359; rs35831577; rs36046590; rs35811606; rs34871919; rs34681548; rs10680526; rs34203893; rs3917013; rs34484900; rs35625117; rs3176872; rs35904710; rs35377403; rs35668724; rs3917050; rs3917061; rs36115922; rs34602730; rs3917046; rs35885801; rs34934334; rs3917039; rs3917045; rs3181090; rs34552536; rs3917054; rs3917035; rs3917030; rs3176865; rs35026515; rs35742683; rs34768146; rs3917044; rs3917017; rs34577442; rs34037455; rs3917029; rs3783606; rs3783600; rs3917021; rs35200787; rs17109912; rs11420952; rs1800821; rs11302130; rs3834000; rs34900848; rs10493936; rs12080503; rs12129732; rs12240047; rs12403247; rs12409568; rs12732056; rs12747073; rs1571049; rs1582090; rs1582091; rs2050471; rs2094241; rs2209628; rs34853105; rs35964031; rs35978793; rs3917078; rs4520436; rs4584412; rs6660837; rs6680254

# Macromolecular_Interacting_Partner_38_General_References:
2688898; 1699207; 1707873; 1715583; 1379595; 1707234; 1377228; 7531291; 7539925

# Macromolecular_Interacting_Partner_38_References:
15068815; 15168812; 16496611

# Macromolecular_Interacting_Partner_39_ID:
8213

# Macromolecular_Interacting_Partner_39_Name:
Chymase precursor

# Macromolecular_Interacting_Partner_39_Synonyms:
Mast cell protease I

# Macromolecular_Interacting_Partner_39_Gene_Name:
CMA1

# Macromolecular_Interacting_Partner_39_Protein_Sequence:
>Chymase precursor
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN

# Macromolecular_Interacting_Partner_39_Number_of_Residues:
247

# Macromolecular_Interacting_Partner_39_Molecular_Weight:
27325

# Macromolecular_Interacting_Partner_39_Theoretical_pI:
9.71

# Macromolecular_Interacting_Partner_39_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_39_General_Function:
Not Available

# Macromolecular_Interacting_Partner_39_Specific_Function:
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion

# Macromolecular_Interacting_Partner_39_Pathway:
Not Available

# Macromolecular_Interacting_Partner_39_Reaction:
Preferential cleavage: Phe-|- > Tyr-|- > Trp-|- > Leu-|-

# Macromolecular_Interacting_Partner_39_Pfam_Domain_Function:
PF00089:Trypsin

# Macromolecular_Interacting_Partner_39_Signals:
1-19

# Macromolecular_Interacting_Partner_39_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_39_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_39_EC_Link:
EC 3.4.21.39

# Macromolecular_Interacting_Partner_39_GenBank_ID_Protein:
180542

# Macromolecular_Interacting_Partner_39_SwissProt_ID:
CMA1_HUMAN (P23946)

# Macromolecular_Interacting_Partner_39_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_39_Genecard_id:
CMA1

# Macromolecular_Interacting_Partner_39_Geneatlas_id:
CMA1

# Macromolecular_Interacting_Partner_39_hgnc_id:
HGNC:2097

# Macromolecular_Interacting_Partner_39_PDB_ID:
1NN6

# Macromolecular_Interacting_Partner_39_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_39_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_39_Subcellular_Location:
Secreted protein. Cytoplasmic granule. Note=Mast cell granules

# Macromolecular_Interacting_Partner_39_Gene_Sequence:
>744 bp
ATGCTGCTTCTTCCTCTCCCCCTGCTGCTCTTTCTCTTGTGCTCCAGAGCTGAAGCTGGG
GAGATCATCGGGGGCACAGAATGCAAGCCACATTCCCGCCCCTACATGGCCTACCTGGAA
ATTGTAACTTCCAACGGTCCCTCAAAATTTTGTGGTGGTTTCCTTATAAGACGGAACTTT
GTGCTGACGGCTGCTCATTGTGCAGGAAGGTCTATAACAGTCACCCTTGGAGCCCATAAC
ATAACAGAGGAAGAAGACACATGGCAGAAGCTTGAGGTTATAAAGCAATTCCGTCATCCA
AAATATAACACTTCTACTCTTCACCACGATATCATGTTACTAAAGTTGAAGGAGAAAGCC
AGCCTGACCCTGGCTGTGGGGACACTCCCCTTCCCATCACAATTCAACTTTGTCCCACCT
GGGAGAATGTGCCGGGTGGCTGGCTGGGGAAGAACAGGTGTGTTGAAGCCGGGCTCAGAC
ACTCTGCAAGAGGTGAAGCTGAGACTCATGGATCCCCAGGCCTGCAGCCACTTCAGAGAC
TTTGACCACAATCTTCAGCTGTGTGTGGGCAATCCCAGGAAGACAAAATCTGCATTTAAG
GGAGACTCTGGGGGCCCTCTTCTGTGTGCTGGGGTGGCCCAGGGCATCGTATCCTATGGA
CGGTCGGATGCAAAGCCCCCTGCTGTCTTCACCCGAATCTCCCATTACCGGCCCTGGATC
AACCAGATCCTGCAGGCAAATTAA

# Macromolecular_Interacting_Partner_39_GenBank_ID_Gene:
M64269

# Macromolecular_Interacting_Partner_39_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_39_Locus:
14q11.2

# Macromolecular_Interacting_Partner_39_SNPs:
rs5247; rs5249; rs1951133; rs1885108; rs2073335; rs12100565; rs10220622; rs10140250; rs5248; rs10135806; rs7153678; rs880678; rs1956923; rs5250; rs1800875; rs5244; rs1956922; rs11623993; rs12892955; rs12893439; rs3759635; rs1800876; rs5245; rs1956920; rs1885110; rs10138131; rs1956921; rs1885109; rs8008222; rs1956924; rs2104080; rs17104478; rs5246; rs13306252; rs13306254; rs7142020; rs13306251; rs13306253; rs35717389; rs5807257; rs8011230; rs34077376; rs10638524; rs2332395; rs2332392; rs34375143; rs8013075; rs2332393; rs12590297; rs5807259; rs2877666; rs34585765; rs34033540; rs2332394; rs5807258; rs34731130; rs4077943; rs35154295; rs36049344; rs2332396; rs11621180; rs11624048; rs12434912; rs12589088; rs17184822; rs17184843; rs1885107; rs1951134; rs1956917; rs1956918; rs1956925; rs1956926; rs1956927; rs1956928; rs1956929; rs1956930; rs1956931; rs1956932; rs1998229; rs1998230; rs2007316; rs2093257; rs2104081; rs2332353; rs2332354; rs34657109; rs4519248; rs4555074; rs4600392; rs4981533; rs4982956; rs6573840; rs7150627; rs7151943; rs7159825; rs8011895; rs911371; rs927278; rs927281

# Macromolecular_Interacting_Partner_39_General_References:
2071582; 1894611; 8495723; 2049082; 9400368; 9931257

# Macromolecular_Interacting_Partner_39_References:
15765403; 16042588; 16150873

# Macromolecular_Interacting_Partner_40_ID:
8081

# Macromolecular_Interacting_Partner_40_Name:
Leptin precursor

# Macromolecular_Interacting_Partner_40_Synonyms:
Obesity factor; Obese protein

# Macromolecular_Interacting_Partner_40_Gene_Name:
LEP

# Macromolecular_Interacting_Partner_40_Protein_Sequence:
>Leptin precursor
MHWGTLCGFLWLWPYLFYVQAVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGL
DFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLP
WASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC

# Macromolecular_Interacting_Partner_40_Number_of_Residues:
167

# Macromolecular_Interacting_Partner_40_Molecular_Weight:
18641

# Macromolecular_Interacting_Partner_40_Theoretical_pI:
6.34

# Macromolecular_Interacting_Partner_40_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_40_General_Function:
Not Available

# Macromolecular_Interacting_Partner_40_Specific_Function:
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass

# Macromolecular_Interacting_Partner_40_Pathway:
Not Available

# Macromolecular_Interacting_Partner_40_Reaction:
Not Available

# Macromolecular_Interacting_Partner_40_Pfam_Domain_Function:
PF02024:Leptin

# Macromolecular_Interacting_Partner_40_Signals:
1-21

# Macromolecular_Interacting_Partner_40_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_40_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_40_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_40_GenBank_ID_Protein:
623332

# Macromolecular_Interacting_Partner_40_SwissProt_ID:
LEP_HUMAN (P41159)

# Macromolecular_Interacting_Partner_40_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_40_Genecard_id:
LEP

# Macromolecular_Interacting_Partner_40_Geneatlas_id:
LEP

# Macromolecular_Interacting_Partner_40_hgnc_id:
HGNC:6553

# Macromolecular_Interacting_Partner_40_PDB_ID:
1AX8

# Macromolecular_Interacting_Partner_40_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_40_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_40_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_40_Gene_Sequence:
>504 bp
ATGCATTGGGGAACCCTGTGCGGATTCTTGTGGCTTTGGCCCTATCTTTTCTATGTCCAA
GCTGTGCCCATCCAAAAAGTCCAAGATGACACCAAAACCCTCATCAAGACAATTGTCACC
AGGATCAATGACATTTCACACACGCAGTCAGTCTCCTCCAAACAGAAAGTCACCGGTTTG
GACTTCATTCCTGGGCTCCACCCCATCCTGACCTTATCCAAGATGGACCAGACACTGGCA
GTCTACCAACAGATCCTCACCAGTATGCCTTCCAGAAACGTGATCCAAATATCCAACGAC
CTGGAGAACCTCCGGGATCTTCTTCACGTGCTGGCCTTCTCTAAGAGCTGCCACTTGCCC
TGGGCCAGTGGCCTGGAGACCTTGGACAGCCTGGGGGGTGTCCTGGAAGCTTCAGGCTAC
TCCACAGAGGTGGTGGCCCTGAGCAGGCTGCAGGGGTCTCTGCAGGACATGCTGTGGCAG
CTGGACCTCAGCCCTGGGTGCTGA

# Macromolecular_Interacting_Partner_40_GenBank_ID_Gene:
U18915

# Macromolecular_Interacting_Partner_40_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_40_Locus:
7q31.3

# Macromolecular_Interacting_Partner_40_SNPs:
rs17151919; rs13306517; rs28954113; rs11763517; rs4731426; rs10954173; rs11761556; rs4731427; rs2167270; rs7791621; rs10257175; rs12706832; rs11760956; rs7795794; rs28954116; rs11978419; rs10244329; rs17151922; rs2278814; rs28959471; rs10954174; rs4236625; rs7796202; rs28954117; rs28959470; rs28954095; rs28954101; rs28954086; rs28954099; rs28959468; rs3750034; rs28954093; rs2278815; rs2122627; rs28954379; rs28959474; rs28954082; rs41457646; rs28954114; rs28954096; rs28959476; rs28954084; rs28954102; rs28954100; rs2060713; rs28954090; rs28954098; rs28954105; rs28954118; rs11980266; rs28954091; rs12706831; rs28959475; rs28954094; rs28954083; rs28756049; rs11973652; rs3793162; rs17151913; rs17151914; rs6956510; rs2071045; rs3828942; rs7788818; rs10264361; rs28954109; rs28954110; rs28954108; rs28954111; rs791616; rs28954376; rs28954081; rs6976701; rs10262600; rs28954369; rs28954080; rs28954371; rs34104384; rs4728096; rs791620; rs28954372; rs28954373; rs28954375; rs35048003; rs28959478; rs10258300; rs12536535; rs28954378; rs13228377; rs1800564; rs1800583; rs28954097; rs11380467; rs35394014; rs28959469; rs10676401; rs28954106; rs1031340; rs28954115; rs1349398; rs34219283; rs28959472; rs28954088; rs10243710; rs6966536; rs28954104; rs10620014; rs34457895; rs13306516; rs33910507; rs28954107; rs41526944; rs41434248; rs28954087; rs34728887; rs28954103; rs28959473; rs41528456; rs17617757; rs28954089; rs28954092; rs34052732; rs10277407; rs28954112; rs41474844; rs13306518; rs35447711; rs34046133; rs36212573; rs28959477; rs36219262; rs791618; rs28954370; rs791619; rs34669250; rs10598051; rs28954377; rs36219261; rs28391558; rs791617; rs28954374; rs36219260; rs10249476; rs10264838; rs10276311; rs10487506; rs10954175; rs10954176; rs11770725; rs12535708; rs12535747; rs12537573; rs13245201; rs1349419; rs1376268; rs16871960; rs17151895; rs2060715; rs2167271; rs35854831; rs4731423; rs4731424; rs4731428; rs4731429; rs4731430; rs6949498; rs712722; rs7778154; rs7782257; rs7798338; rs7799039; rs7801674; rs7802530; rs791604; rs791606; rs791607; rs791608; rs791610; rs791611; rs791612; rs791613; rs791614; rs791615

# Macromolecular_Interacting_Partner_40_General_References:
7984236; 7789654; 8626726; 7499240; 8621021; 10428856; 9166907; 9144295; 9500540

# Macromolecular_Interacting_Partner_40_References:
15605705

# Macromolecular_Interacting_Partner_41_ID:
8227

# Macromolecular_Interacting_Partner_41_Name:
T-lymphocyte activation antigen CD86 precursor

# Macromolecular_Interacting_Partner_41_Synonyms:
Activation B7-2 antigen; CTLA-4 counter-receptor B7.2; B70; FUN-1; BU63

# Macromolecular_Interacting_Partner_41_Gene_Name:
CD86

# Macromolecular_Interacting_Partner_41_Protein_Sequence:
>Tlymphocyte activation antigen CD86 precursor
MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQ
ENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGM
IRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTI
EYDGIMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQ
PPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQTKKREK
IHIPERSDEAQRVFKSSKTSSCDKSDTCF

# Macromolecular_Interacting_Partner_41_Number_of_Residues:
329

# Macromolecular_Interacting_Partner_41_Molecular_Weight:
37697

# Macromolecular_Interacting_Partner_41_Theoretical_pI:
6.91

# Macromolecular_Interacting_Partner_41_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_41_General_Function:
Not Available

# Macromolecular_Interacting_Partner_41_Specific_Function:
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation

# Macromolecular_Interacting_Partner_41_Pathway:
Not Available

# Macromolecular_Interacting_Partner_41_Reaction:
Not Available

# Macromolecular_Interacting_Partner_41_Pfam_Domain_Function:
PF07686:V-set

# Macromolecular_Interacting_Partner_41_Signals:
1-23

# Macromolecular_Interacting_Partner_41_Transmembrane_Regions:
248-268

# Macromolecular_Interacting_Partner_41_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_41_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_41_GenBank_ID_Protein:
439839

# Macromolecular_Interacting_Partner_41_SwissProt_ID:
CD86_HUMAN (P42081)

# Macromolecular_Interacting_Partner_41_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_41_Genecard_id:
CD86

# Macromolecular_Interacting_Partner_41_Geneatlas_id:
CD86

# Macromolecular_Interacting_Partner_41_hgnc_id:
HGNC:1705

# Macromolecular_Interacting_Partner_41_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_41_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_41_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_41_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_41_Gene_Sequence:
>972 bp
ATGGGACTGAGTAACATTCTCTTTGTGATGGCCTTCCTGCTCTCTGGTGCTGCTCCTCTG
AAGATTCAAGCTTATTTCAATGAGACTGCAGACCTGCCATGCCAATTTGCAAACTCTCAA
AACCAAAGCCTGAGTGAGCTAGTAGTATTTTGGCAGGACCAGGAAAACTTGGTTCTGAAT
GAGGTATACTTAGGCAAAGAGAAATTTGACAGTGTTCATTCCAAGTATATGGGCCGCACA
AGTTTTGATTCGGACAGTTGGACCCTGAGACTTCACAATCTTCAGATCAAGGACAAGGGC
TTGTATCAATGTATCATCCATCACAAAAAGCCCACAGGAATGATTCGCATCCACCAGATG
AATTCTGAACTGTCAGTGCTTGCTAACTTCAGTCAACCTGAAATAGTACCAATTTCTAAT
ATAACAGAAAATGTGTACATAAATTTGACCTGCTCATCTATACACGGTTACCCAGAACCT
AAGAAGATGAGTGTTTTGCTAAGAACCAAGAATTCAACTATCGAGTATGATGGTATTATG
CAGAAATCTCAAGATAATGTCACAGAACTGTACGACGTTTCCATCAGCTTGTCTGTTTCA
TTCCCTGATGTTACGAGCAATATGACCATCTTCTGTATTCTGGAAACTGACAAGACGCGG
CTTTTATCTTCACCTTTCTCTATAGAGCTTGAGGACCCTCAGCCTCCCCCAGACCACATT
CCTTGGATTACAGCTGTACTTCCAACAGTTATTATATGTGTGATGGTTTTCTGTCTAATT
CTATGGAAATGGAAGAAGAAGAAGCGGCCTCGCAACTCTTATAAATGTGGAACCAACACA
ATGGAGAGGGAAGAGAGTGAACAGACCAAGAAAAGAGAAAAAATCCATATACCTGAAAGA
TCTGATGAAGCCCAGCGTGTTTTTAAAAGTTCGAAGACATCTTCATGCGACAAAAGTGAT
ACATGTTTTTAA

# Macromolecular_Interacting_Partner_41_GenBank_ID_Gene:
U04343

# Macromolecular_Interacting_Partner_41_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_41_Locus:
3q21

# Macromolecular_Interacting_Partner_41_SNPs:
rs2681417; rs1129055; rs9282642; rs9282648; rs9831894; rs2715261; rs11717893; rs6780894; rs2715262; rs17281995; rs2681422; rs2715279; rs1915087; rs6805035; rs2715280; rs11575853; rs3749202; rs9282641; rs9282646; rs9282644; rs2681426; rs2681408; rs2715273; rs2681411; rs2715259; rs2715274; rs2681406; rs4315642; rs2715271; rs6786977; rs2681413; rs2681404; rs2681410; rs2715276; rs2001791; rs2715275; rs2715268; rs6808869; rs2681400; rs2681414; rs6804964; rs2715278; rs4308217; rs2332096; rs2715260; rs2681416; rs2681420; rs13074706; rs17203439; rs2681415; rs3792285; rs9836399; rs2681409; rs13095010; rs1915092; rs1915091; rs10511408; rs9848900; rs11921048; rs17203397; rs17281953; rs13064913; rs35187120; rs9880031; rs13075281; rs11713851; rs9799128; rs9860244; rs13090719; rs3792287; rs2715256; rs11922347; rs2715270; rs6781910; rs16832682; rs2715263; rs12495492; rs3804588; rs2715258; rs17203418; rs2715277; rs2001750; rs9282643; rs2715257; rs13082681; rs16832688; rs2254911; rs16832684; rs9872483; rs13090103; rs4678186; rs16832687; rs9289187; rs2254909; rs11712647; rs11575855; rs35276006; rs34865701; rs34080512; rs34158795; rs12330615; rs10622189; rs10620302; rs5852292; rs36226545; rs10561530; rs35919036; rs10711632; rs9282647; rs9859708; rs9282645; rs36107436; rs4678194; rs10710310; rs2681405; rs36038203; rs10582753; rs5852291; rs11272713; rs35956394; rs35078137; rs11425812; rs2681412; rs6798227; rs41271423; rs35084274; rs16832666; rs36082374; rs36226551; rs34259868; rs1915089; rs35826672; rs5852290; rs34076269; rs34974842; rs34263779; rs35891398; rs34331291; rs7626829; rs35061302; rs9839555; rs11375248; rs35598890; rs11441404; rs9815492; rs2255017; rs34902179; rs6778942; rs35010283; rs34647267; rs1915090; rs36226874; rs34420369; rs36226553; rs34027270; rs12106776; rs41271425; rs34824004; rs36226548; rs35479648; rs3828358; rs10580127; rs2681407; rs1806623; rs34652460; rs35736887; rs35819494; rs36226549; rs35139209; rs28495824; rs11304672; rs35742296; rs34693048; rs10576484; rs2681421; rs35815615; rs34141864; rs13087981; rs7612850; rs1915088; rs3792286; rs36226875; rs2715255; rs34365367; rs4048621; rs35938587; rs34972450; rs35699129; rs4453794; rs35190602; rs34861031; rs35582595; rs5852289; rs10704212; rs3804589; rs34269845; rs28715970; rs10704317; rs2681418; rs2715269; rs11341158; rs35060876; rs2681399; rs13320942; rs5852293; rs4440072; rs10703820; rs13091051; rs2255214; rs2262495; rs2681401; rs2681402; rs2681403; rs2681423; rs2681424; rs2681425; rs2715265; rs2715266; rs2715267; rs2715272; rs2946792; rs6438696; rs9879600

# Macromolecular_Interacting_Partner_41_General_References:
7694153; 7694363; 11162656; 7541777; 7527824; 7520767

# Macromolecular_Interacting_Partner_41_References:
12603604

# Macromolecular_Interacting_Partner_42_ID:
7850

# Macromolecular_Interacting_Partner_42_Name:
Neuron-specific protein family member 1

# Macromolecular_Interacting_Partner_42_Synonyms:
Brain neuron cytoplasmic protein 1

# Macromolecular_Interacting_Partner_42_Gene_Name:
NSG1

# Macromolecular_Interacting_Partner_42_Protein_Sequence:
>Neuronspecific protein family member 1
MVKLGNNFAEKGTKQPLLEDGFDTIPLMTPLDVNQLQFPPPDKVVVKTKTEYEPDRKKGK
ARPPQIAEFTVSITEGVTERFKVSVLVLFALAFLTCVVFLVVYKVYKYDRACPDGFVLKN
TQCIPEGLESYYAEQDSSAREKFYTVINHYNLAKQSITRSVSPWMSVLSEEKLSEQETEA
AEKSA

# Macromolecular_Interacting_Partner_42_Number_of_Residues:
185

# Macromolecular_Interacting_Partner_42_Molecular_Weight:
20913

# Macromolecular_Interacting_Partner_42_Theoretical_pI:
5.40

# Macromolecular_Interacting_Partner_42_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  G-protein-coupled receptor binding
Function:  dopamine receptor binding
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
Process:  dopamine receptor signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_42_General_Function:
Not Available

# Macromolecular_Interacting_Partner_42_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_42_Pathway:
Not Available

# Macromolecular_Interacting_Partner_42_Reaction:
Not Available

# Macromolecular_Interacting_Partner_42_Pfam_Domain_Function:
PF06387:Calcyon

# Macromolecular_Interacting_Partner_42_Signals:
None

# Macromolecular_Interacting_Partner_42_Transmembrane_Regions:
83-103

# Macromolecular_Interacting_Partner_42_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_42_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_42_GenBank_ID_Protein:
190261

# Macromolecular_Interacting_Partner_42_SwissProt_ID:
NSG1_HUMAN (P42857)

# Macromolecular_Interacting_Partner_42_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_42_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_42_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_42_hgnc_id:
Not Available

# Macromolecular_Interacting_Partner_42_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_42_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_42_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_42_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_42_Gene_Sequence:
>558 bp
ATGGTGAAGTTGGGGAACAATTTCGCAGAGAAGGGCACCAAGCAGCCGCTGCTGGAGGAT
GGCTTCGACACCATTCCCCTGATGACGCCCCTCGATGTCAATCAGCTGCAGTTCCCGCCC
CCGGATAAGGTGGTCGTGAAAACTAAGACCGAGTATGAACCTGACCGCAAGAAAGGGAAA
GCACGTCCTCCCCAAATTGCTGAGTTCACCGTCAGCATCACGGAGGGTGTCACCGAGAGG
TTTAAGGTCTCCGTGTTGGTCCTCTTCGCCCTGGCCTTCCTCACCTGCGTCGTCTTCCTG
GTTGTCTACAAGGTGTACAAGTATGACCGCGCCTGCCCCGATGGGTTCGTCCTCAAGAAC
ACCCAGTGCATCCCAGAAGGCTTGGAGAGCTACTACGCGGAGCAAGACTCCAGTGCCCGG
GAGAAATTTTACACAGTCATAAACCACTACAACCTGGCCAAGCAGAGCATCACGCGCTCC
GTATCGCCCTGGATGTCAGTTCTGTCAGAAGAGAAGCTGTCCGAGCAGGAGACTGAAGCG
GCTGAGAAGTCAGCTTAG

# Macromolecular_Interacting_Partner_42_GenBank_ID_Gene:
M98529

# Macromolecular_Interacting_Partner_42_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_42_Locus:
Not Available

# Macromolecular_Interacting_Partner_42_SNPs:
Not Available

# Macromolecular_Interacting_Partner_42_General_References:
9013775

# Macromolecular_Interacting_Partner_42_References:
12806965; 12823590; 12840224; 12840228

# Macromolecular_Interacting_Partner_43_ID:
8000

# Macromolecular_Interacting_Partner_43_Name:
Tumor necrosis factor ligand superfamily member 10

# Macromolecular_Interacting_Partner_43_Synonyms:
TNF-related apoptosis-inducing ligand; Protein TRAIL; Apo-2 ligand; Apo-2L; CD253 antigen

# Macromolecular_Interacting_Partner_43_Gene_Name:
TNFSF10

# Macromolecular_Interacting_Partner_43_Protein_Sequence:
>Tumor necrosis factor ligand superfamily member 10
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE
DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ
RVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKG
FYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLY
SIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG

# Macromolecular_Interacting_Partner_43_Number_of_Residues:
281

# Macromolecular_Interacting_Partner_43_Molecular_Weight:
32509

# Macromolecular_Interacting_Partner_43_Theoretical_pI:
7.49

# Macromolecular_Interacting_Partner_43_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_43_General_Function:
Not Available

# Macromolecular_Interacting_Partner_43_Specific_Function:
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis

# Macromolecular_Interacting_Partner_43_Pathway:
Not Available

# Macromolecular_Interacting_Partner_43_Reaction:
Not Available

# Macromolecular_Interacting_Partner_43_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_43_Signals:
1-32

# Macromolecular_Interacting_Partner_43_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_43_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_43_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_43_GenBank_ID_Protein:
1149558

# Macromolecular_Interacting_Partner_43_SwissProt_ID:
TNF10_HUMAN (P50591)

# Macromolecular_Interacting_Partner_43_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_43_Genecard_id:
TNFSF10

# Macromolecular_Interacting_Partner_43_Geneatlas_id:
TNFSF10

# Macromolecular_Interacting_Partner_43_hgnc_id:
HGNC:11925

# Macromolecular_Interacting_Partner_43_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_43_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_43_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_43_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_43_Gene_Sequence:
>846 bp
ATGGCTATGATGGAGGTCCAGGGGGGACCCAGCCTGGGACAGACCTGCGTGCTGATCGTG
ATCTTCACAGTGCTCCTGCAGTCTCTCTGTGTGGCTGTAACTTACGTGTACTTTACCAAC
GAGCTGAAGCAGATGCAGGACAAGTACTCCAAAAGTGGCATTGCTTGTTTCTTAAAAGAA
GATGACAGTTATTGGGACCCCAATGACGAAGAGAGTATGAACAGCCCCTGCTGGCAAGTC
AAGTGGCAACTCCGTCAGCTCGTTAGAAAGATGATTTTGAGAACCTCTGAGGAAACCATT
TCTACAGTTCAAGAAAAGCAACAAAATATTTCTCCCCTAGTGAGAGAAAGAGGTCCTCAG
AGAGTAGCAGCTCACATAACTGGGACCAGAGGAAGAAGCAACACATTGTCTTCTCCAAAC
TCCAAGAATGAAAAGGCTCTGGGCCGCAAAATAAACTCCTGGGAATCATCAAGGAGTGGG
CATTCATTCCTGAGCAACTTGCACTTGAGGAATGGTGAACTGGTCATCCATGAAAAAGGG
TTTTACTACATCTATTCCCAAACATACTTTCGATTTCAGGAGGAAATAAAAGAAAACACA
AAGAACGACAAACAAATGGTCCAATATATTTACAAATACACAAGTTATCCTGACCCTATA
TTGTTGATGAAAAGTGCTAGAAATAGTTGTTGGTCTAAAGATGCAGAATATGGACTCTAT
TCCATCTATCAAGGGGGAATATTTGAGCTTAAGGAAAATGACAGAATTTTTGTTTCTGTA
ACAAATGAGCACTTGATAGACATGGACCATGAAGCCAGTTTTTTCGGGGCCTTTTTAGTT
GGCTAA

# Macromolecular_Interacting_Partner_43_GenBank_ID_Gene:
U37518

# Macromolecular_Interacting_Partner_43_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_43_Locus:
3q26

# Macromolecular_Interacting_Partner_43_SNPs:
rs16845759; rs6763816; rs1131532; rs1131535; rs1131542; rs17600346; rs1131580; rs1131579; rs1131568; rs3136602; rs231983; rs3136594; rs3181143; rs231981; rs3136587; rs1126161; rs3136608; rs3181139; rs3136597; rs3136601; rs3136598; rs3136606; rs7625589; rs3819773; rs6775921; rs6802485; rs2270418; rs3136599; rs3136600; rs3136603; rs3136596; rs4894559; rs3136589; rs3815496; rs3136607; rs231985; rs2270417; rs1823227; rs231982; rs3136605; rs3181140; rs6784241; rs3136591; rs3136604; rs3136609; rs3774314; rs3181141; rs3821821; rs231987; rs7643953; rs231984; rs231986; rs2241063; rs3774315; rs3181142; rs3136588; rs6802197; rs3774313; rs3774316; rs6801105; rs3136593; rs13076985; rs9865753; rs231979; rs16845780; rs3136592; rs179777; rs3216506; rs9852651; rs9879386; rs3136595; rs3819772; rs231980; rs6777176; rs388515; rs365238; rs9811650; rs9859259; rs9869255; rs3136586; rs3136581; rs9859809; rs432251; rs9811673; rs2860864; rs11720451; rs9811928; rs6783667; rs9859413; rs12696330; rs13089978; rs3136584; rs6807069; rs3136583; rs9873546; rs9869065; rs12488654; rs432821; rs9869551; rs9811646; rs9811639; rs4491934; rs11545817; rs41308132; rs17848014; rs41309772; rs36073561; rs33927039; rs17848022; rs35009921; rs35275903; rs6805054; rs34112044; rs11360845; rs11285482; rs6792667; rs17848027; rs36066568; rs35543813; rs17848018; rs11333712; rs35005998; rs35045041; rs10706597; rs17848023; rs10543824; rs34276385; rs10562888; rs11456314; rs11330298; rs35452093; rs5854474; rs9682939; rs17848024; rs3136590; rs17848019; rs11574670; rs36100137; rs35502466; rs10716802; rs3836481; rs5854475; rs17848021; rs3832247; rs33985142; rs11328072; rs11290814; rs17848025; rs9848845; rs10576110; rs35975099; rs17848015; rs9848839; rs11270839; rs34173943; rs7653559; rs11328471; rs6809850; rs11276567; rs10663063; rs7631904; rs6796310; rs13061406; rs7645745; rs16845791; rs10804846; rs11706116; rs11918343; rs11925997; rs12633330; rs1597086; rs16848052; rs17535790; rs17601515; rs1992868; rs2041691; rs2041692; rs2041693; rs2080199; rs232004; rs233998; rs3136610; rs9817507; rs9854603; rs9855107; rs9855144; rs9880475; rs9880799

# Macromolecular_Interacting_Partner_43_General_References:
8777713; 8663110; 10549288; 10542098; 10485660

# Macromolecular_Interacting_Partner_43_References:
15142888; 16007142; 16096370

# Macromolecular_Interacting_Partner_44_ID:
8452

# Macromolecular_Interacting_Partner_44_Name:
Lymphotoxin-beta

# Macromolecular_Interacting_Partner_44_Synonyms:
LT-beta; Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3

# Macromolecular_Interacting_Partner_44_Gene_Name:
LTB

# Macromolecular_Interacting_Partner_44_Protein_Sequence:
>Lymphotoxinbeta
MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD
PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS
DAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLE
GAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGA
VMVG

# Macromolecular_Interacting_Partner_44_Number_of_Residues:
244

# Macromolecular_Interacting_Partner_44_Molecular_Weight:
25390

# Macromolecular_Interacting_Partner_44_Theoretical_pI:
5.02

# Macromolecular_Interacting_Partner_44_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_44_General_Function:
Not Available

# Macromolecular_Interacting_Partner_44_Specific_Function:
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional

# Macromolecular_Interacting_Partner_44_Pathway:
Not Available

# Macromolecular_Interacting_Partner_44_Reaction:
Not Available

# Macromolecular_Interacting_Partner_44_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_44_Signals:
1-35

# Macromolecular_Interacting_Partner_44_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_44_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_44_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_44_GenBank_ID_Protein:
292279

# Macromolecular_Interacting_Partner_44_SwissProt_ID:
TNFC_HUMAN (Q06643)

# Macromolecular_Interacting_Partner_44_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_44_Genecard_id:
LTB

# Macromolecular_Interacting_Partner_44_Geneatlas_id:
LTB

# Macromolecular_Interacting_Partner_44_hgnc_id:
HGNC:6711

# Macromolecular_Interacting_Partner_44_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_44_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_44_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_44_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_44_Gene_Sequence:
>735 bp
ATGGGGGCACTGGGGCTGGAGGGCAGGGGTGGGAGGCTCCAGGGGAGGGGTTCCCTCCTG
CTAGCTGTGGCAGGAGCCACTTCTCTGGTGACCTTGTTGCTGGCGGTGCCTATCACTGTC
CTGGCTGTGCTGGCCTTAGTGCCCCAGGATCAGGGAGGACTGGTAACGGAGACGGCCGAC
CCCGGGGCACAGGCCCAGCAAGGACTGGGGTTTCAGAAGCTGCCAGAGGAGGAGCCAGAA
ACAGATCTCAGCCCCGGGCTCCCAGCTGCCCACCTCATAGGCGCTCCGCTGAAGGGGCAG
GGGCTAGGCTGGGAGACGACGAAGGAACAGGCGTTTCTGACGAGCGGGACGCAGTTCTCG
GACGCCGAGGGGCTGGCGCTCCCGCAGGACGGCCTCTATTACCTCTACTGTCTCGTCGGC
TACCGGGGCCGGGCGCCCCCTGGCGGCGGGGACCCCCAGGGCCGCTCGGTCACGCTGCGC
AGCTCTCTGTACCGGGCGGGGGGCGCCTACGGGCCGGGCACTCCCGAGCTGCTGCTCGAG
GGCGCCGAGACGGTGACTCCAGTGCTGGACCCGGCCAGGAGACAAGGGTACGGGCCTCTC
TGGTACACGAGCGTGGGGTTCGGCGGCCTGGTGCAGCTCCGGAGGGGCGAGAGGGTGTAC
GTCAACATCAGTCACCCCGATATGGTGGACTTCGCGAGAGGGAAGACCTTCTTTGGGGCC
GTGATGGTGGGGTGA

# Macromolecular_Interacting_Partner_44_GenBank_ID_Gene:
L11016

# Macromolecular_Interacting_Partner_44_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_44_Locus:
6p21.3

# Macromolecular_Interacting_Partner_44_SNPs:
Not Available

# Macromolecular_Interacting_Partner_44_General_References:
7916655; 9299492; 10202016

# Macromolecular_Interacting_Partner_44_References:
12570825; 14512034; 15068815; 15318170

# Macromolecular_Interacting_Partner_45_ID:
7962

# Macromolecular_Interacting_Partner_45_Name:
Trefoil factor 3 precursor

# Macromolecular_Interacting_Partner_45_Synonyms:
Intestinal trefoil factor; hP1.B

# Macromolecular_Interacting_Partner_45_Gene_Name:
TFF3

# Macromolecular_Interacting_Partner_45_Protein_Sequence:
>Trefoil factor 3 precursor
MAARALCMLGLVLALLSSSSAEEYVGLSANQCAVPAKDRVDCGYPHVTPKECNNRGCCFD
SRIPGVPWCFKPLQEAECTF

# Macromolecular_Interacting_Partner_45_Number_of_Residues:
80

# Macromolecular_Interacting_Partner_45_Molecular_Weight:
8641

# Macromolecular_Interacting_Partner_45_Theoretical_pI:
5.74

# Macromolecular_Interacting_Partner_45_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_45_General_Function:
Not Available

# Macromolecular_Interacting_Partner_45_Specific_Function:
May have a role in promoting cell migration (motogen)

# Macromolecular_Interacting_Partner_45_Pathway:
Not Available

# Macromolecular_Interacting_Partner_45_Reaction:
Not Available

# Macromolecular_Interacting_Partner_45_Pfam_Domain_Function:
PF00088:Trefoil

# Macromolecular_Interacting_Partner_45_Signals:
1-21

# Macromolecular_Interacting_Partner_45_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_45_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_45_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_45_GenBank_ID_Protein:
402483

# Macromolecular_Interacting_Partner_45_SwissProt_ID:
TFF3_HUMAN (Q07654)

# Macromolecular_Interacting_Partner_45_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_45_Genecard_id:
TFF3

# Macromolecular_Interacting_Partner_45_Geneatlas_id:
TFF3

# Macromolecular_Interacting_Partner_45_hgnc_id:
HGNC:11757

# Macromolecular_Interacting_Partner_45_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_45_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_45_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_45_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_45_Gene_Sequence:
>243 bp
ATGGCTGCCAGAGCGCTCTGCATGCTGGGGCTGGTCCTGGCCTTGCTGTCCTCCAGCTCT
GCTGAGGAGTACGTGGGCCTGTCTGCAAACCAGTGTGCCGTGCCAGCCAAGGACAGGGTG
GACTGCGGCTACCCCCATGTCACCCCCAAGGAGTGCAACAACCGGGGCTGCTGCTTTGAC
TCCAGGATCCCTGGAGTGCCTTGGTGTTTCAAGCCCCTGCAGGAAGCAGAATGCACCTTC
TGA

# Macromolecular_Interacting_Partner_45_GenBank_ID_Gene:
L15203

# Macromolecular_Interacting_Partner_45_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_45_Locus:
Not Available

# Macromolecular_Interacting_Partner_45_SNPs:
rs11701143; rs533093; rs2236705; rs225361; rs538407; rs225360; rs2236706; rs225362; rs576445; rs225438; rs225437; rs225363; rs9975547; rs11702422; rs11203194; rs225439; rs11203193; rs11203195; rs12626785; rs1788375; rs11546961; rs11546960; rs1804098; rs2282554; rs4920083; rs9976749; rs9975628; rs9754071; rs35033018; rs10687546; rs3838116; rs9975550; rs34315392; rs35770757; rs9980474; rs10084557; rs11203197; rs11701491; rs11909013; rs11910365; rs11910395; rs12483623; rs13046698; rs15661; rs17177760; rs178742; rs186528; rs186529; rs192011; rs225366; rs225367; rs225368; rs225369; rs225414; rs225415; rs225416; rs225417; rs225418; rs225419; rs225420; rs225434; rs225435; rs225436; rs2839485; rs419063; rs480289; rs480449; rs6586305; rs6586306; rs6586307; rs6586308; rs691567; rs692356; rs7275471; rs7276176; rs7277338; rs7277545; rs7280100; rs7281065; rs7281211; rs7282516; rs7283110; rs7283700; rs8128478; rs8130260; rs8130267; rs8131519; rs8133510; rs8133631; rs9981660

# Macromolecular_Interacting_Partner_45_General_References:
8346203; 9070946; 10950923; 10830953; 8454642

# Macromolecular_Interacting_Partner_45_References:
16254517

# Macromolecular_Interacting_Partner_46_ID:
7816

# Macromolecular_Interacting_Partner_46_Name:
Histone deacetylase 1

# Macromolecular_Interacting_Partner_46_Synonyms:
HD1

# Macromolecular_Interacting_Partner_46_Gene_Name:
HDAC1

# Macromolecular_Interacting_Partner_46_Protein_Sequence:
>Histone deacetylase 1
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA

# Macromolecular_Interacting_Partner_46_Number_of_Residues:
482

# Macromolecular_Interacting_Partner_46_Molecular_Weight:
55104

# Macromolecular_Interacting_Partner_46_Theoretical_pI:
5.16

# Macromolecular_Interacting_Partner_46_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Function:  histone deacetylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid deacetylation
Process:  histone deacetylation
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_46_General_Function:
Chromatin structure and dynamics 

# Macromolecular_Interacting_Partner_46_Specific_Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes

# Macromolecular_Interacting_Partner_46_Pathway:
Not Available

# Macromolecular_Interacting_Partner_46_Reaction:
Not Available

# Macromolecular_Interacting_Partner_46_Pfam_Domain_Function:
PF00850:Hist_deacetyl

# Macromolecular_Interacting_Partner_46_Signals:
None

# Macromolecular_Interacting_Partner_46_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_46_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_46_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_46_GenBank_ID_Protein:
1277084

# Macromolecular_Interacting_Partner_46_SwissProt_ID:
HDAC1_HUMAN (Q13547)

# Macromolecular_Interacting_Partner_46_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_46_Genecard_id:
HDAC1

# Macromolecular_Interacting_Partner_46_Geneatlas_id:
HDAC1

# Macromolecular_Interacting_Partner_46_hgnc_id:
HGNC:4852

# Macromolecular_Interacting_Partner_46_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_46_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_46_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_46_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_46_Gene_Sequence:
>1449 bp
ATGGCGCAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGGGATGTTGGA
AATTACTATTATGGACAAGGCCACCCAATGAAGCCTCACCGAATCCGCATGACTCATAAT
TTGCTGCTCAACTATGGTCTCTACCGAAAAATGGAAATCTATCGCCCTCACAAAGCCAAT
GCTGAGGAGATGACCAAGTACCACAGCGATGACTACATTAAATTCTTGCGCTCCATCCGT
CCAGATAACATGTCGGAGTACAGCAAGCAGATGCAGAGATTCAACGTTGGTGAGGACTGT
CCAGTATTCGATGGCCTGTTTGAGTTCTGTCAGTTGTCTACTGGTGGTTCTGTGGCAAGT
GCTGTGAAACTTAATAAGCAGCAGACGGACATCGCTGTGAATTGGGCTGGGGGCCTGCAC
CATGCAAAGAAGTCCGAGGCATCTGGCTTCTGTTACGTCAATGATATCGTCTTGGCCATC
CTGGAACTGCTAAAGTATCACCAGAGGGTGCTGTACATTGACATTGATATTCACCATGGT
GACGGCGTGGAAGAGGCCTTCTACACCACGGACCGGGTCATGACTGTGTCCTTTCATAAG
TATGGAGAGTACTTCCCAGGAACTGGGGACCTACGGGATATCGGGGCTGGCAAAGGCAAG
TATTATGCTGTTAACTACCCGCTCCGAGACGGGATTGATGACGAGTCCTATGAGGCCATT
TTCAAGCCGGTCATGTCCAAAGTAATGGAGATGTTCCAGCCTAGTGCGGTGGTCTTACAG
TGTGGCTCAGACTCCCTATCTGGGGATCGGTTAGGTTGCTTCAATCTAACTATCAAAGGA
CACGCCAAGTGTGTGGAATTTGTCAAGAGCTTTAACCTGCCTATGCTGATGCTGGGAGGC
GGTGGTTACACCATTCGTAACGTTGCCCGGTGCTGGACATATGAGACAGCTGTGGCCCTG
GATACGGAGATCCCTAATGAGCTTCCATACAATGACTACTTTGAATACTTTGGACCAGAT
TTCAAGCTCCACATCAGTCCTTCCAATATGACTAACCAGAACACGAATGAGTACCTGGAG
AAGATCAAACAGCGACTGTTTGAGAACCTTAGAATGCTGCCGCACGCACCTGGGGTCCAA
ATGCAGGCGATTCCTGAGGACGCCATCCCTGAGGAGAGTGGCGATGAGGACGAAGACGAC
CCTGACAAGCGCATCTCGATCTGCTCCTCTGACAAACGAATTGCCTGTGAGGAAGAGTTC
TCCGATTCTGAAGAGGAGGGAGAGGGGGGCCGCAAGAACTCTTCCAACTTCAAAAAAGCC
AAGAGAGTCAAAACAGAGGATGAAAAAGAGAAAGACCCAGAGGAGAAGAAAGAAGTCACC
GAAGAGGAGAAAACCAAGGAGGAGAAGCCAGAAGCCAAAGGGGTCAAGGAGGAGGTCAAG
TTGGCCTGA

# Macromolecular_Interacting_Partner_46_GenBank_ID_Gene:
U50079

# Macromolecular_Interacting_Partner_46_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_46_Locus:
1p34

# Macromolecular_Interacting_Partner_46_SNPs:
rs8176782; rs6697130; rs7543692; rs16834954; rs16834956; rs16834958; rs16834963; rs16834957; rs12133048; rs17507358; rs12096858; rs17255809; rs690334; rs2127246; rs10914548; rs1741981; rs1140658; rs1140673; rs11541185; rs11541183; rs11541184; rs1140660; rs8176783; rs10914552; rs690332; rs35808493; rs12026405; rs552686; rs7533676; rs6679175; rs34899445; rs7512341; rs10914547; rs10914551; rs12723325; rs552733; rs34315355; rs34267128; rs12758327; rs10914546; rs12734422; rs34371852; rs10652556; rs34065217; rs10465520; rs690520; rs35894142; rs28419695; rs471372; rs35770915; rs34386633; rs552732; rs34447178; rs12727854; rs35678923; rs34021057; rs34742550; rs28372816; rs11589444; rs35790615; rs10465522; rs12022567; rs690006; rs690525; rs2019923; rs34403317; rs7544100; rs9699564; rs35191653; rs35577659; rs35345816; rs10465521; rs34304672; rs36212114; rs11459069; rs36212119; rs36212122; rs36211753; rs35299850; rs36212118; rs36212115; rs36212123; rs36212121; rs36212117; rs12090734; rs36212116; rs34992032; rs35764672; rs1042546; rs10914545; rs11576036; rs11576040; rs11576043; rs11807976; rs11809371; rs12048924; rs8176768; rs8176777; rs8176781

# Macromolecular_Interacting_Partner_46_General_References:
8602529; 8646880; 10487760; 10898795; 10669754; 11602581; 11331609; 11102443; 11427533; 12032081; 12670868; 12493763; 12482978; 12724404; 10904264

# Macromolecular_Interacting_Partner_46_References:
15051827

# Macromolecular_Interacting_Partner_47_ID:
8202

# Macromolecular_Interacting_Partner_47_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_47_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_47_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_47_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_47_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_47_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_47_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_47_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_47_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_47_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_47_Pathway:
Not Available

# Macromolecular_Interacting_Partner_47_Reaction:
Not Available

# Macromolecular_Interacting_Partner_47_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_47_Signals:
None

# Macromolecular_Interacting_Partner_47_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_47_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_47_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_47_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_47_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_47_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_47_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_47_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_47_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_47_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_47_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_47_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_47_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_47_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_47_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_47_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_47_Locus:
10q22

# Macromolecular_Interacting_Partner_47_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_47_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_47_References:
12692060; 16541197

# Macromolecular_Interacting_Partner_48_ID:
7934

# Macromolecular_Interacting_Partner_48_Name:
Integrin alpha-11 precursor

# Macromolecular_Interacting_Partner_48_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_48_Gene_Name:
ITGA11

# Macromolecular_Interacting_Partner_48_Protein_Sequence:
>Integrin alpha11 precursor
MDLPRGLVVAWALSLWPGFTDTFNMDTRKPRVIPGSRTAFFGYTVQQHDISGNKWLVVGA
PLETNGYQKTGDVYKCPVIHGNCTKLNLGRVTLSNVSERKDNMRLGLSLATNPKDNSFLA
CSPLWSHECGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVE
VQHFLINILKKFYIGPGQIQVGVVQYGEDVVHEFHLNDYRSVKDVVEAASHIEQRGGTET
RTAFGIEFARSEAFQKGGRKGAKKVMIVITDGESHDSPDLEKVIQQSERDNVTRYAVAVL
GYYNRRGINPETFLNEIKYIASDPDDKHFFNVTDEAALKDIVDALGDRIFSLEGTNKNET
SFGLEMSQTGFSSHVVEDGVLLGAVGAYDWNGAVLKETSAGKVIPLRESYLKEFPEELKN
HGAYLGYTVTSVVSSRQGRVYVAGAPRFNHTGKVILFTMHNNRSLTIHQAMRGQQIGSYF
GSEITSVDIDGDGVTDVLLVGAPMYFNEGRERGKVYVYELRQNRFVYNGTLKDSHSYQNA
RFGSSIASVRDLNQDSYNDVVVGAPLEDNHAGAIYIFHGFRGSILKTPKQRITASELATG
LQYFGCSIHGQLDLNEDGLIDLAVGALGNAVILWSRPVVQINASLHFEPSKINIFHRDCK
RSGRDATCLAAFLCFTPIFLAPHFQTTTVGIRYNATMDERRYTPRAHLDEGGDRFTNRAV
LLSSGQELCERINFHVLDTADYVKPVTFSVEYSLEDPDHGPMLDDGWPTTLRVSVPFWNG
CNEDEHCVPDLVLDARSDLPTAMEYCQRVLRKPAQDCSAYTLSFDTTVFIIESTRQRVAV
EATLENRGENAYSTVLNISQSANLQFASLIQKEDSDGSIECVNEERRLQKQVCNVSYPFF
RAKAKVAFRLDFEFSKSIFLHHLEIELAAGSDSNERDSTKEDNVAPLRFHLKYEADVLFT
RSSSLSHYEVKLNSSLERYDGIGPPFSCIFRIQNLGLFPIHGIMMKITIPIATRSGNRLL
KLRDFLTDEVANTSCNIWGNSTEYRPTPVEEDLRRAPQLNHSNSDVVSINCNIRLVPNQE
INFHLLGNLWLRSLKALKYKSMKIMVNAALQRQFHSPFIFREEDPSRQIVFEISKQEDWQ
VPIWIIVGSTLGGLLLLALLVLALWKLGFFRSARRRREPGLDPTPKVLE

# Macromolecular_Interacting_Partner_48_Number_of_Residues:
1189

# Macromolecular_Interacting_Partner_48_Molecular_Weight:
133612

# Macromolecular_Interacting_Partner_48_Theoretical_pI:
6.74

# Macromolecular_Interacting_Partner_48_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cell-substrate adhesion
Process:  cell-matrix adhesion
Process:  cellular process
Process:  cell adhesion
 ||
>>>
Component:  protein complex
Component:  receptor complex
Component:  integrin complex

# Macromolecular_Interacting_Partner_48_General_Function:
Not Available

# Macromolecular_Interacting_Partner_48_Specific_Function:
Integrin alpha-11/beta-1 is a receptor for collagen

# Macromolecular_Interacting_Partner_48_Pathway:
Not Available

# Macromolecular_Interacting_Partner_48_Reaction:
Not Available

# Macromolecular_Interacting_Partner_48_Pfam_Domain_Function:
PF01839:FG-GAP;
PF08441:Integrin_alpha2;
PF00092:VWA

# Macromolecular_Interacting_Partner_48_Signals:
1-22

# Macromolecular_Interacting_Partner_48_Transmembrane_Regions:
1143-1165

# Macromolecular_Interacting_Partner_48_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_48_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_48_GenBank_ID_Protein:
6013141

# Macromolecular_Interacting_Partner_48_SwissProt_ID:
ITA11_HUMAN (Q9UKX5)

# Macromolecular_Interacting_Partner_48_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_48_Genecard_id:
ITGA11

# Macromolecular_Interacting_Partner_48_Geneatlas_id:
ITGA11

# Macromolecular_Interacting_Partner_48_hgnc_id:
HGNC:6136

# Macromolecular_Interacting_Partner_48_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_48_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_48_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_48_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_48_Gene_Sequence:
>3570 bp
ATGGACCTGCCCAGGGGCCTGGTGGTGGCCTGGGCGCTCAGCCTGTGGCCAGGGTTCACG
GACACCTTCAACATGGACACCAGGAAGCCCCGGGTCATCCCTGGCTCCAGGACCGCCTTC
TTTGGCTACACAGTGCAGCAGCACGACATCAGTGGCAATAAGTGGCTGGTCGTGGGCGCC
CCACTGGAAACCAATGGCTACCAGAAGACGGGAGACGTGTACAAGTGTCCAGTGATCCAC
GGGAACTGCACCAAACTCAACCTGGGAAGGGTCACCCTGTCCAACGTGTCCGAGCGGAAA
GACAACATGCGCCTCGGCCTTAGTCTCGCCACCAACCCCAAGGACAACAGCTTCCTGGCC
TGCAGCCCCCTCTGGTCTCATGAGTGTGGGAGCTCCTACTACACCACAGGGATGTGTTCA
AGAGTCAACTCCAACTTCAGGTTCTCCAAGACCGTGGCCCCAGCTCTCCAAAGGTGCCAG
ACCTACATGGACATCGTCATTGTCCTGGATGGCTCCAACAGCATCTACCCCTGGGTGGAG
GTTCAGCACTTCCTCATCAACATCCTGAAAAAGTTTTACATTGGCCCAGGGCAGATCCAG
GTTGGAGTTGTGCAGTATGGCGAAGATGTGGTGCATGAGTTTCACCTCAATGACTACAGG
TCTGTAAAAGATGTGGTGGAAGCTGCCAGCCACATTGAGCAGAGAGGAGGAACAGAGACC
CGGACGGCATTTGGCATTGAATTTGCACGCTCAGAGGCTTTCCAGAAGGGTGGAAGGAAA
GGAGCCAAGAAGGTGATGATTGTCATCACAGATGGGGAGTCCCACGACAGCCCAGACCTG
GAGAAGGTGATCCAGCAAAGCGAAAGAGACAACGTAACAAGATATGCGGTGGCCGTCCTG
GGCTACTACAACCGCAGGGGGATCAATCCAGAAACTTTTCTAAATGAAATCAAATACATC
GCCAGTGACCCTGATGACAAGCACTTCTTCAATGTCACTGATGAGGCTGCCTTGAAGGAC
ATTGTCGATGCCCTGGGGGACAGAATCTTCAGCCTGGAAGGCACCAACAAGAACGAGACC
TCCTTTGGGCTGGAGATGTCACAGACGGGCTTTTCCTCGCACGTGGTGGAGGATGGGGTT
CTGCTGGGAGCCGTCGGTGCCTATGACTGGAATGGAGCTGTGCTAAAGGAGACGAGTGCC
GGGAAGGTCATTCCTCTCCGCGAGTCCTACCTGAAAGAGTTCCCCGAGGAGCTCAAGAAC
CATGGTGCATACCTGGGGTACACAGTCACATCGGTCGTGTCCTCCAGGCAGGGGCGAGTG
TACGTGGCCGGAGCCCCCCGGTTCAACCACACGGGCAAGGTCATCCTGTTCACCATGCAC
AACAACCGGAGCCTCACCATCCACCAGGCTATGCGGGGCCAGCAGATAGGCTCTTACTTT
GGGAGTGAAATCACCTCGGTGGACATCGACGGCGACGGCGTGACTGATGTCCTGCTGGTG
GGCGCACCCATGTACTTCAACGAGGGCCGTGAGCGAGGCAAGGTGTACGTCTATGAGCTG
AGACAGAACCGGTTTGTTTATAACGGAACGCTAAAGGATTCACACAGTTACCAGAATGCC
CGATTTGGGTCCTCCATTGCCTCAGTTCGAGACCTCAACCAGGATTCCTACAATGACGTG
GTGGTGGGAGCCCCCCTGGAGGACAACCACGCAGGAGCCATCTACATCTTCCACGGCTTC
CGAGGCAGCATCCTGAAGACACCTAAGCAGAGAATCACAGCCTCAGAGCTGGCTACCGGC
CTCCAGTATTTTGGCTGCAGCATCCACGGGCAATTGGACCTCAATGAGGATGGGCTCATC
GACCTGGCAGTGGGAGCCCTTGGCAACGCTGTGATTCTGTGGTCCCGCCCAGTGGTTCAG
ATCAATGCCAGCCTCCACTTTGAGCCATCCAAGATCAACATCTTCCACAGAGACTGCAAG
CGCAGTGGCAGGGATGCCACCTGCCTGGCCGCCTTCCTCTGCTTCACGCCCATCTTCCTG
GCACCCCATTTCCAAACAACAACTGTTGGCATCAGATACAACGCCACCATGGATGAGAGG
CGGTATACACCGAGGGCCCACCTGGACGAGGGCGGGGACCGATTCACCAACAGAGCCGTA
CTGCTCTCCTCCGGCCAGGAGCTCTGTGAGCGGATCAACTTCCATGTCCTGGACACTGCT
GACTACGTGAAGCCAGTGACCTTCTCAGTCGAGTATTCCCTGGAGGACCCTGACCATGGC
CCCATGCTGGACGACGGCTGGCCCACCACTCTCAGAGTCTCGGTGCCCTTCTGGAACGGC
TGCAATGAGGATGAGCACTGTGTCCCTGACCTTGTGTTGGATGCCCGGAGTGACCTGCCC
ACGGCCATGGAGTACTGCCAGAGGGTGCTGAGGAAGCCTGCGCAGGACTGCTCCGCATAC
ACGCTGTCCTTCGACACCACAGTCTTCATCATAGAGAGCACACGCCAGCGAGTGGCGGTG
GAGGCCACACTGGAGAACAGGGGCGAGAACGCCTACAGCACGGTCCTAAATATCTCGCAG
TCAGCAAACCTGCAGTTTGCCAGCTTGATCCAGAAGGAGGACTCAGACGGTAGCATTGAG
TGTGTGAACGAGGAGAGGAGGCTCCAGAAGCAAGTCTGCAACGTCAGCTATCCCTTCTTC
CGGGCCAAGGCCAAGGTGGCTTTCCGTCTTGATTTTGAGTTCAGCAAATCCATCTTCCTA
CACCACCTGGAGATCGAGCTCGCTGCAGGCAGTGACAGTAATGAGCGGGACAGCACCAAG
GAAGACAACGTGGCCCCCTTACGCTTCCACCTCAAATACGAGGCTGACGTCCTCTTCACC
AGGAGCAGCAGCCTGAGCCACTACGAGGTCAAGCTCAACAGCTCGCTGGAGAGATACGAT
GGTATCGGGCCTCCCTTCAGCTGCATCTTCAGGATCCAGAACTTGGGCTTGTTCCCCATC
CACGGGATTATGATGAAGATCACCATTCCCATCGCCACCAGGAGCGGCAACCGCCTACTG
AAGCTGAGGGACTTCCTCACGGACGAGGTAGCGAACACGTCCTGTAACATCTGGGGCAAT
AGCACTGAGTACCGGCCCACCCCAGTGGAGGAAGACTTGCGTCGTGCTCCACAGCTGAAT
CACAGCAACTCTGATGTCGTCTCCATCAACTGCAATATACGGCTGGTCCCCAACCAGGAA
ATCAATTTCCATCTACTGGGGAACCTGTGGTTGAGGTCCCTAAAAGCACTCAAGTACAAA
TCCATGAAAATCATGGTCAACGCAGCCTTGCAGAGGCAGTTCCACAGCCCCTTCATCTTC
CGTGAGGAGGATCCCAGCCGCCAGATCGTGTTTGAGATCTCCAAGCAAGAGGACTGGCAG
GTCCCCATCTGGATCATTGTAGGCAGCACCCTGGGGGGCCTCCTACTGCTGGCCCTGCTG
GTCCTGGCACTGTGGAAGCTCGGCTTCTTTAGAAGTGCCAGGCGCAGGAGGGAGCCTGGT
CTGGACCCCACCCCCAAAGTGCTGGAGTGA

# Macromolecular_Interacting_Partner_48_GenBank_ID_Gene:
AF109681

# Macromolecular_Interacting_Partner_48_Chromosome_Location:
Chromosome:15

# Macromolecular_Interacting_Partner_48_Locus:
15q23

# Macromolecular_Interacting_Partner_48_SNPs:
rs2271725; rs4777035; rs2306022; rs2306024; rs7168069; rs3736493; rs2271724; rs2306023; rs9302249; rs2292745; rs2271728; rs2271720; rs12907890; rs11629460; rs3736494; rs1122247; rs12148843; rs3817330; rs10851784; rs754399; rs898586; rs967565; rs2279101; rs1460644; rs898581; rs8041260; rs11072020; rs7176267; rs4617801; rs8039349; rs3784351; rs12443350; rs4238412; rs8038368; rs8035431; rs8036698; rs11630897; rs7174755; rs1476222; rs3784350; rs898580; rs970264; rs895137; rs11629808; rs750158; rs8035990; rs7170808; rs2306021; rs8040014; rs11635082; rs7170403; rs4776398; rs967566; rs11630977; rs6494735; rs8043127; rs7176011; rs7169854; rs7179228; rs7172210; rs4777049; rs12595773; rs11072015; rs12050670; rs11857985; rs6494736; rs8036939; rs1007617; rs11631030; rs4777033; rs7162189; rs9920271; rs7182849; rs11858032; rs895135; rs11072016; rs1115528; rs4777051; rs11857615; rs4777037; rs3736491; rs898590; rs4777048; rs11632400; rs8024010; rs748892; rs8043152; rs964691; rs4408487; rs9972560; rs5016065; rs11072021; rs11634026; rs12441197; rs1982592; rs4776397; rs12442156; rs4777036; rs898579; rs7176145; rs11855593; rs2415008; rs898584; rs11637286; rs3784345; rs7180218; rs2415001; rs11853855; rs7165618; rs11634100; rs2306012; rs4776402; rs11853718; rs1077731; rs11637293; rs2271723; rs12591673; rs7176173; rs17252387; rs8029230; rs11630284; rs11072010; rs4517737; rs8025985; rs3816612; rs16952065; rs11630928; rs6494743; rs11639240; rs11638575; rs8029838; rs1516871; rs2061564; rs7162991; rs2415000; rs3784346; rs4777041; rs7174916; rs4777046; rs6494732; rs16952005; rs4777039; rs4356422; rs7171871; rs11072014; rs16951961; rs2306013; rs2271722; rs4776404; rs8029113; rs4477640; rs16951767; rs7179347; rs7163918; rs8036876; rs1380881; rs7169899; rs1460645; rs11858758; rs11637346; rs16952001; rs4500670; rs4777034; rs10162690; rs16952059; rs11072011; rs7161791; rs11633421; rs1350733; rs6494742; rs4777040; rs11636019; rs1380883; rs8029162; rs7183704; rs8028967; rs11857338; rs2169213; rs16951778; rs2271721; rs4419008; rs11856183; rs8043262; rs1125721; rs16951774; rs9672310; rs7161871; rs898577; rs2415006; rs11637411; rs8042664; rs748891; rs16951954; rs4238414; rs11072012; rs1075991; rs3736495; rs7497049; rs11858293; rs4776405; rs8041788; rs8042999; rs2415009; rs4776394; rs16952036; rs11633614; rs2415002; rs4776399; rs3784334; rs4777042; rs11635699; rs898582; rs898589; rs6494734; rs1516869; rs3784347; rs7182350; rs2306020; rs2169214; rs11630443; rs10851785; rs7167822; rs2125998; rs16951777; rs2306015; rs11072009; rs7168991; rs2415005; rs4777047; rs16951841; rs8042862; rs898576; rs16952052; rs11072013; rs12595779; rs8028971; rs17318470; rs3784348; rs11634499; rs4776396; rs7168997; rs11852504; rs1824478; rs1020842; rs2306018; rs1813565; rs11635643; rs10851786; rs1319223; rs11072008; rs2414994; rs7164150; rs4375610; rs12440936; rs12592461; rs11637463; rs3784335; rs6494731; rs4776403; rs2306014; rs8030538; rs8030178; rs898593; rs748971; rs10400907; rs7179545; rs16951819; rs895136; rs6494738; rs2306019; rs11636813; rs8042710; rs11855998; rs1380882; rs16951816; rs12591421; rs2306025; rs4777045; rs11856272; rs3784349; rs12914609; rs10851787; rs11634149; rs2306017; rs16951746; rs7164335; rs10444851; rs2415007; rs3784336; rs12441412; rs7179598; rs1020841; rs4776400; rs1077730; rs11858012; rs1563894; rs2305078; rs11632266; rs2415003; rs4536409; rs898575; rs11635776; rs1007615; rs16952041; rs11632656; rs1975874; rs11635712; rs11072018; rs8042332; rs1124577; rs898587; rs8030943; rs1516870; rs2414996; rs7178537; rs2125999; rs4299097; rs2125997; rs6494733; rs17320635; rs16951999; rs7173365; rs16951750; rs2414998; rs967567; rs1841405; rs4777038; rs4777050; rs2306016; rs2899736; rs898583; rs16951765; rs8031003; rs11858671; rs3784342; rs2125996; rs8039820; rs4605110; rs7165305; rs7173815; rs4776395; rs898594; rs1841404; rs11637375; rs16952056; rs898574; rs9783729; rs4454914; rs716379; rs6494740; rs3784344; rs2414997; rs8031936; rs7173564; rs11852717; rs1533469; rs2271726; rs3816611; rs16951835; rs7164172; rs1542473; rs2899735; rs2414995; rs898592; rs7403417; rs7176339; rs12443183; rs8029452; rs17266192; rs11630750; rs7496244; rs7181198; rs7166628; rs898585; rs967564; rs3784337; rs6494744; rs1470415; rs4426302; rs7176148; rs1445024; rs12915814; rs733574; rs3084584; rs12591263; rs34645431; rs28675010; rs1106706; rs28832076; rs12912332; rs28820967; rs34407903; rs28632038; rs33910742; rs34456821; rs1237911; rs4363820; rs11072017; rs2100003; rs1239019; rs16951868; rs35452602; rs4318156; rs28479079; rs35079218; rs8023993; rs11858232; rs34701287; rs8038774; rs28430608; rs28497433; rs34739598; rs35400299; rs11855056; rs10580084; rs12595520; rs11274413; rs7165603; rs10647873; rs4776401; rs9672383; rs8029186; rs35400442; rs34098259; rs2415004; rs34583165; rs28685790; rs11858237; rs11438057; rs28453743; rs4567653; rs1460643; rs28493712; rs28469639; rs34781411; rs5813485; rs10584732; rs10584731; rs34351994; rs35139299; rs35688044; rs5813489; rs12441591; rs8024015; rs35562050; rs13329519; rs34470974; rs35619732; rs3084640; rs34903160; rs34360809; rs34899976; rs28415078; rs33913338; rs5813482; rs34637773; rs11072007; rs8028080; rs11632946; rs35860391; rs4238413; rs35808090; rs8040548; rs28584322; rs7169698; rs28449432; rs898578; rs28620930; rs1077732; rs8028747; rs34800998; rs28517670; rs35874078; rs7164238; rs36078545; rs3084639; rs35280222; rs35325204; rs5813486; rs2271729; rs34438637; rs34704980; rs10574703; rs4777044; rs34297295; rs28669764; rs34222567; rs28695547; rs34278524; rs3084641; rs35584050; rs10618087; rs16952015; rs1542474; rs34822014; rs28740972; rs6494739; rs12591448; rs8032290; rs5813483; rs12898972; rs7174384; rs28442582; rs12902013; rs36216483; rs11858258; rs34660674; rs11632959; rs34338447; rs4777043; rs10565230; rs3837691; rs11858261; rs1824479; rs11854515; rs898591; rs16952019; rs28884935; rs34559605; rs2271727; rs34726895; rs28634234; rs35970041; rs898595; rs11072006; rs34588195; rs12593835; rs28434753; rs10580840; rs28522005; rs8029011; rs16951779; rs6494741; rs34224367; rs34119426; rs12914851; rs12442960; rs11424476; rs11428988; rs28401309; rs12912832; rs2084033; rs34918989; rs35499724; rs12899284; rs7181259; rs28665430; rs35325769; rs6145615; rs34136572; rs28363966; rs11638124; rs28394587; rs34001731; rs1870646; rs34840804; rs5813492; rs5813488; rs35178663; rs2414999; rs28711817; rs9630432; rs28713626; rs1996361; rs35284300; rs11380346; rs16951820; rs33914028; rs28436003; rs5813487; rs4533222; rs35094508; rs35035217; rs3837690; rs12441877; rs28768146; rs34640987; rs35071996; rs35051383; rs28672317; rs34079664; rs28491879; rs11072005; rs28735807; rs28613431; rs12050550; rs3084605; rs28723505; rs9672395; rs12593553; rs35634579; rs11853861; rs35666288; rs10569599; rs35025145; rs35900942; rs28591120; rs34501075; rs11855108; rs12592187; rs36096585; rs3084602; rs16952017; rs28461989; rs28460512; rs35426923; rs35952951; rs28566900; rs10567819; rs4402499; rs34030877; rs34618079; rs5813491; rs7177709; rs898588; rs28404208; rs7174690; rs35904581; rs12593571; rs4517738; rs28480552; rs34220669; rs35455543; rs28592619; rs36112980; rs34122553; rs7177979; rs5813484; rs34788905; rs12908869; rs35563812; rs28683053; rs34467259; rs34009804; rs10444850; rs11072002; rs11072003; rs11072004; rs11072022; rs11072025; rs12438807; rs12442355; rs12593610; rs12593620; rs12593625; rs12593626; rs12593634; rs12594282; rs12595056; rs12899005; rs12904888; rs12906388; rs12913105; rs12913467; rs12913696; rs12914614; rs1373699; rs1445022; rs1445023; rs2415015; rs2415016; rs2415017; rs2415018; rs28452190; rs2899738; rs34702468; rs35906516; rs4280184; rs4410025; rs4999936; rs4999937; rs6494730; rs6494745; rs7162348; rs7163188; rs7167102; rs7167465; rs7168990; rs7172173; rs7172500; rs8043066; rs8043202; rs920922; rs920923; rs920924

# Macromolecular_Interacting_Partner_48_General_References:
10486209; 10464311

# Macromolecular_Interacting_Partner_48_References:
12692060; 14566963; 14592659; 16019930

# Macromolecular_Interacting_Partner_49_ID:
8408

# Macromolecular_Interacting_Partner_49_Name:
Zinc finger protein 148

# Macromolecular_Interacting_Partner_49_Synonyms:
Zinc finger DNA-binding protein 89; Transcription factor ZBP-89

# Macromolecular_Interacting_Partner_49_Gene_Name:
ZNF148

# Macromolecular_Interacting_Partner_49_Protein_Sequence:
>Zinc finger protein 148
MNIDDKLEGLFLKCGGIDEMQSSRTMVVMGGVSGQSTVSGELQDSVLQDRSMPHQEILAA
DEVLQESEMRQQDMISHDELMVHEETVKNDEEQMETHERLPQGLQYALNVPISVKQEITF
TDVSEQLMRDKKQIREPVDLQKKKKRKQRSPAKILTINEDGSLGLKTPKSHVCEHCNAAF
RTNYHLQRHVFIHTGEKPFQCSQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGMRFIQKY
HMERHKRTHSGEKPYQCEYCLQYFSRTDRVLKHKRMCHENHDKKLNRCAIKGGLLTSEED
SGFSTSPKDNSLPKKKRQKTEKKSSGMDKESALDKSDLKKDKNDYLPLYSSSTKVKDEYM
VAEYAVEMPHSSVGGSHLEDASGEIHPPKLVLKKINSKRSLKQPLEQNQTISPLSTYEES
KVSKYAFELVDKQALLDSEGNADIDQVDNLQEGPSKPVHSSTNYDDAMQFLKKKRYLQAA
SNNSREYALNVGTIASQPSVTQAAVASVIDESTTASILESQALNVEIKSNHDKNVIPDEV
LQTLLDHYSHKANGQHEISFSVADTEVTSSISINSSEVPEVTPSENVGSSSQASSSDKAN
MLQEYSKFLQQALDRTSQNDAYLNSPSLNFVTDNQTLPNQPAFSSIDKQVYATMPINSFR
SGMNSPLRTTPDKSHFGLIVGDSQHSFPFSGDETNHASATSTQDFLDQVTSQKKAEAQPV
HQAYQMSSFEQPFRAPYHGSRAGIATQFSTANGQVNLRGPGTSAEFSEFPLVNVNDNRAG
MTSSPDATTGQTFG

# Macromolecular_Interacting_Partner_49_Number_of_Residues:
794

# Macromolecular_Interacting_Partner_49_Molecular_Weight:
88977

# Macromolecular_Interacting_Partner_49_Theoretical_pI:
6.46

# Macromolecular_Interacting_Partner_49_GO_Classification:
>>>
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  binding
Function:  nucleic acid binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_49_General_Function:
Not Available

# Macromolecular_Interacting_Partner_49_Specific_Function:
Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes

# Macromolecular_Interacting_Partner_49_Pathway:
Not Available

# Macromolecular_Interacting_Partner_49_Reaction:
Not Available

# Macromolecular_Interacting_Partner_49_Pfam_Domain_Function:
PF00096:zf-C2H2

# Macromolecular_Interacting_Partner_49_Signals:
None

# Macromolecular_Interacting_Partner_49_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_49_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_49_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_49_GenBank_ID_Protein:
2828110

# Macromolecular_Interacting_Partner_49_SwissProt_ID:
ZN148_HUMAN (Q9UQR1)

# Macromolecular_Interacting_Partner_49_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_49_Genecard_id:
ZNF148

# Macromolecular_Interacting_Partner_49_Geneatlas_id:
ZNF148

# Macromolecular_Interacting_Partner_49_hgnc_id:
HGNC:12933

# Macromolecular_Interacting_Partner_49_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_49_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_49_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_49_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_49_Gene_Sequence:
>2385 bp
ATGAACATTGACGACAAACTGGAAGGATTGTTTCTTAAATGTGGCGGCATAGACGAAATG
CAGTCTTCCAGGACAATGGTTGTAATGGGTGGAGTGTCTGGCCAGTCTACTGTGTCTGGA
GAGCTACAGGATTCAGTACTTCAAGATCGAAGTATGCCTCACCAGGAGATCCTTGCTGCA
GATGAAGTGTTACAAGAAAGTGAAATGAGACAACAGGATATGATATCACATGATGAACTC
ATGGTCCATGAGGAGACAGTGAAAAATGATGAAGAGCAGATGGAAACACATGAAAGACTT
CCTCAAGGACTACAGTATGCACTTAATGTCCCTATAAGCGTAAAGCAGGAAATTACTTTT
ACTGATGTATCTGAGCAACTGATGAGAGACAAAAAACAAATCAGAGAGCCAGTAGACTTA
CAGAAAAAGAAGAAGCGGAAACAACGTTCTCCCGCAAAAATCCTTACAATAAATGAGGAT
GGATCACTTGGTTTGAAAACCCCTAAATCTCACGTTTGTGAGCACTGCAATGCTGCCTTT
AGAACGAACTATCACTTACAGAGACATGTCTTCATTCATACAGGTGAAAAACCATTTCAA
TGTAGTCAATGTGACATGCGTTTCATACAGAAGTACCTGCTTCAGAGACATGAGAAGATT
CATACTGGTGAAAAACCATTTCGCTGTGATGAATGTGGTATGAGATTCATACAAAAATAT
CATATGGAAAGGCATAAGAGAACTCATAGTGGAGAAAAACCTTACCAGTGTGAATACTGT
TTACAGTATTTTTCCAGAACAGATCGTGTATTGAAACATAAACGTATGTGCCATGAAAAT
CATGACAAAAAACTAAATAGATGTGCCATCAAAGGTGGCCTTCTGACATCTGAGGAAGAT
TCTGGCTTTTCTACATCACCAAAAGACAACTCACTGCCAAAAAAGAAAAGGCAGAAAACG
GAGAAAAAATCATCTGGAATGGACAAAGAGAGTGCTTTGGACAAATCTGACCTGAAAAAA
GACAAAAATGATTACTTGCCTCTTTATTCTTCAAGTACTAAAGTAAAAGATGAGTATATG
GTTGCAGAATATGCTGTTGAAATGCCACATTCGTCAGTTGGGGGCTCGCATTTAGAAGAT
GCGTCAGGAGAAATACACCCACCTAAGTTAGTTCTCAAAAAAATTAATAGTAAGAGAAGT
CTGAAACAGCCACTGGAGCAAAATCAAACAATTTCACCTTTATCCACATATGAAGAGAGC
AAAGTTTCAAAGTATGCTTTTGAACTTGTGGATAAACAGGCTTTACTGGACTCAGAAGGC
AATGCTGACATTGATCAGGTTGATAATTTGCAGGAGGGGCCCAGTAAACCTGTGCATAGT
AGTACTAATTATGATGATGCCATGCAGTTTTTGAAGAAGAAGCGGTATCTTCAAGCAGCA
AGTAACAACAGCAGGGAATATGCGCTGAATGTGGGTACCATAGCTTCTCAGCCTTCTGTA
ACACAAGCAGCTGTGGCAAGTGTCATTGATGAAAGTACCACGGCATCCATATTAGAGTCA
CAGGCACTGAATGTGGAGATTAAGAGTAATCATGACAAAAATGTTATTCCAGATGAGGTA
CTGCAGACTCTGTTGGATCATTATTCCCACAAAGCTAATGGACAGCATGAGATATCCTTC
AGTGTTGCAGATACTGAAGTGACTTCTAGCATATCAATAAATTCTTCAGAAGTACCAGAG
GTCACCCCGTCAGAGAATGTTGGATCAAGCTCCCAAGCATCCTCATCAGATAAAGCCAAC
ATGTTGCAGGAATACTCCAAGTTTCTGCAGCAGGCTTTGGACAGAACTAGCCAAAATGAT
GCCTATTTGAATAGCCCGAGCCTTAACTTTGTGACTGATAACCAGACCCTCCCAAATCAG
CCAGCATTCTCTTCCATAGACAAGCAGGTCTATGCCACCATGCCCATCAATAGCTTTCGA
TCAGGAATGAATTCTCCACTAAGAACAACTCCAGATAAGTCCCACTTTGGACTAATAGTT
GGTGATTCACAGCACTCATTTCCCTTTTCAGGTGATGAGACAAACCATGCTTCTGCCACA
TCAACACAGGACTTTCTGGATCAAGTGACTTCTCAGAAGAAAGCTGAGGCCCAGCCTGTC
CACCAAGCTTACCAAATGAGCTCCTTTGAACAGCCCTTCCGTGCTCCCTATCATGGATCA
AGAGCTGGAATAGCTACTCAATTTAGCACTGCCAATGGACAGGTGAACCTTCGGGGACCA
GGGACAAGTGCTGAATTTTCAGAATTTCCCTTGGTGAATGTAAATGATAATAGAGCTGGG
ATGACATCTTCACCTGATGCCACAACTGGCCAGACTTTTGGCTAA

# Macromolecular_Interacting_Partner_49_GenBank_ID_Gene:
AF039019

# Macromolecular_Interacting_Partner_49_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_49_Locus:
3q21

# Macromolecular_Interacting_Partner_49_SNPs:
rs1053737; rs1053738; rs12695453; rs9877328; rs7609684; rs4679387; rs6438898; rs12637629; rs7643632; rs2333197; rs12485473; rs4679385; rs9882663; rs6438895; rs9855330; rs9857500; rs6804933; rs6438896; rs11711167; rs6787332; rs6780042; rs9835788; rs9851008; rs9844360; rs9289250; rs9849383; rs6438897; rs10048926; rs4303833; rs4386447; rs9289251; rs6767136; rs4679167; rs9851588; rs10512647; rs7609964; rs6808088; rs6808899; rs4508729; rs2333199; rs4679384; rs16836745; rs13086821; rs4679168; rs7609696; rs9883247; rs6807980; rs13098926; rs13074986; rs6773670; rs7620704; rs9853337; rs11708180; rs7647548; rs10049453; rs4679383; rs9814274; rs7431183; rs9289249; rs16836746; rs4679388; rs9855686; rs7647459; rs6792293; rs7635104; rs9815953; rs12695451; rs4679390; rs6787226; rs7620790; rs9880725; rs2333198; rs12636970; rs1982491; rs12487071; rs2333200; rs7642600; rs1850506; rs987956; rs2333196; rs1999921; rs7615139; rs9857356; rs9289245; rs4679163; rs2168237; rs9870428; rs1338543; rs7652521; rs2011442; rs1455050; rs9858110; rs4450756; rs1961457; rs9850300; rs6772299; rs6438885; rs7615040; rs2039718; rs4679162; rs1975760; rs1999919; rs7638240; rs6781706; rs4679373; rs4679382; rs17330607; rs7612285; rs9858524; rs6800532; rs9858336; rs9882766; rs6807163; rs1349972; rs1607238; rs2066042; rs6438892; rs1455049; rs6438887; rs9820507; rs1999920; rs4679380; rs7615035; rs4679160; rs1455051; rs9840737; rs4679161; rs6438893; rs7650116; rs6784650; rs4679375; rs1869673; rs2168238; rs9879936; rs7619480; rs11914990; rs17264366; rs7623450; rs9859543; rs9832629; rs9816308; rs6438890; rs6438888; rs4416340; rs6784613; rs11709450; rs9862499; rs7637986; rs12330741; rs9816044; rs9866637; rs13061044; rs9818938; rs16836696; rs4679378; rs13077440; rs1823937; rs6792807; rs1574955; rs13078585; rs12490924; rs12695449; rs17330495; rs9870577; rs2061085; rs6810205; rs9840709; rs9870660; rs16836673; rs11915021; rs9839414; rs4679379; rs6438886; rs13062873; rs9856122; rs9832089; rs16836687; rs1817183; rs2009385; rs9860377; rs9814573; rs9826108; rs9852389; rs6438889; rs897323; rs9876342; rs4679376; rs2124189; rs13063765; rs510232; rs13090865; rs9857232; rs35950048; rs28728401; rs4679389; rs9713555; rs34067371; rs34621131; rs13074969; rs35430872; rs11434686; rs6764137; rs34184012; rs34931859; rs35452665; rs34179909; rs2168240; rs9859881; rs1060677; rs13092518; rs35441943; rs35694328; rs28884867; rs35820239; rs35695528; rs28727333; rs34316893; rs35337513; rs10662690; rs34843090; rs6808922; rs11434687; rs36092446; rs35562223; rs36126015; rs10621610; rs35548970; rs6783614; rs35419054; rs13094075; rs36070409; rs35145293; rs35879999; rs34896111; rs11719317; rs35589189; rs11719535; rs35672726; rs35233433; rs13073553; rs12634008; rs13320826; rs35916755; rs4300967; rs35258657; rs35210971; rs34288521; rs7428004; rs35144076; rs13094901; rs2877871; rs35810148; rs9861092; rs9825838; rs10663485; rs34003819; rs35637240; rs10565589; rs34214611; rs1982492; rs9842209; rs11316937; rs11303817; rs11377888; rs9840035; rs13097753; rs35424904; rs34087588; rs11274826; rs10706935; rs34792480; rs10625384; rs12639336; rs35915240; rs3030724; rs13065790; rs11452294; rs34826461; rs11274143; rs28538016; rs35755172; rs11383689; rs33978796; rs35351859; rs11348713; rs35989620; rs28464853; rs11375767; rs34770537; rs11425391; rs35024355; rs11344103; rs34630272; rs34414126; rs35656114; rs13314322; rs35800258; rs9289248; rs35340375; rs36032396; rs35831798; rs35801712; rs35838836; rs35470190; rs35673839; rs35398611; rs35659393; rs4679386; rs9824581; rs12493676; rs13079615; rs34332871; rs34370274; rs35674201; rs35756256; rs34017965; rs35645862; rs34188004; rs11420317; rs10709074; rs6768561; rs11391406; rs10627611; rs34797795; rs13100611; rs35734762; rs12630804; rs34921303; rs35917851; rs11312460; rs34104281; rs35524011; rs35668096; rs4679377; rs10576530; rs34515779; rs10709075; rs11373915; rs33942993; rs4679374; rs10659643; rs34918292; rs36077089; rs13091801; rs34739205; rs35068331; rs2168239; rs34424875; rs28416214; rs3030721; rs9868362; rs34338575; rs12485955; rs34418638; rs35379059; rs35758679; rs11925389; rs35297197; rs34401724; rs35343498; rs28521594; rs34093385; rs35404141; rs11278645; rs10613321; rs35304183; rs34388942; rs34880801; rs35679388; rs7624547; rs7633384; rs35018622; rs34892309; rs11463727; rs35108764; rs34381138; rs11435462; rs35986994; rs34643582; rs34168423; rs10704518; rs9816482; rs34592713; rs34437717; rs9819774; rs35142216; rs6791415; rs5852454; rs36206841; rs9839400; rs28375751; rs1960105; rs11425970; rs10567631; rs2333195; rs13091911; rs13327822; rs10689484; rs34024592; rs9813844; rs10621538; rs35704064; rs10565566; rs7612355; rs36003000; rs10712959; rs9917630; rs34760585; rs9831954; rs10623312; rs28530557; rs34469920; rs13071312; rs28656952; rs34440978; rs10703884; rs2061086; rs35270198; rs11385803; rs34533587; rs34364842; rs36051348; rs7646487; rs7625154; rs9867262; rs5852453; rs35106221; rs13060274; rs34456399; rs35502723; rs9834163; rs1988178; rs35415615; rs11456933; rs34772918; rs33910439; rs10703127; rs34943558; rs5852452; rs34995896; rs35923292; rs34847960; rs34055193; rs34037323; rs35524024; rs35749016; rs13074468; rs34788281; rs35531442; rs11425971; rs11370338; rs34560368; rs11391775; rs9854879; rs35313913; rs35844943; rs11441831; rs34133011; rs11425236; rs35145256; rs13323832; rs34632630; rs36112318; rs1046752; rs11924106; rs13573; rs2292520; rs2292803; rs4679169; rs4679372; rs592528; rs592559; rs6801477; rs7623968; rs936078; rs936079; rs936080; rs9840783

# Macromolecular_Interacting_Partner_49_General_References:
9457682; 10359087

# Macromolecular_Interacting_Partner_49_References:
12622418

End of HMDB00039

Beginning of HMDB00042
# Accession_No:
HMDB00042

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-23 12:29:02

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Acetic acid

# Description:
Acetic acid is one of the simplest carboxylic acids. It is an important chemical reagent and industrial chemical that is used in the production of plastic soft drink bottles, photographic film; and polyvinyl acetate for wood glue, as well as many synthetic fibres and fabrics. In households diluted acetic acid is often used as a cleaning agent. In the food industry acetic acid is used as an acidity regulator. The acetyl group, derived from acetic acid, is fundamental to the biochemistry of virtually all forms of life. When bound to coenzyme A it is central to the metabolism of carbohydrates and fats. However, the concentration of free acetic acid in cells is kept at a low level to avoid disrupting the control of the pH of the cell contents. Acetic acid is produced and excreted by certain bacteria, notably the Acetobacter genus and Clostridium acetobutylicum. These bacteria are found universally in foodstuffs, water, and soil, and acetic acid is produced naturally as fruits and some other foods spoil. Acetic acid is also a component of the vaginal lubrication of humans and other primates, where it appears to serve as a mild antibacterial agent.

# Synonyms:
Acetate; Ethanoate; Ethanoic acid; Ethylate; Ethylic acid; Glacial acetate; Glacial acetic acid; Kyselina octova; Methanecarboxylate; Methanecarboxylic acid; Vinegar; Vinegar acid

# Chemical_IUPAC_Name:
acetic acid

# Chemical_Formula:
C2H4O2

# Chemical_Structure:
tbl_chemical:::HMDB00042_ZOOM.png:::119283150177790422

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00042_THUMB.png:::119283150004686336

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
carboxylic acid

# Taxonomy_Biofunction:
Component of Glycerophospholipid metabolism; Component of Propanoate metabolism; Component of Pyruvate metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
60.02113

# Molecular_Weight_Avg:
60.05196

# Smiles_String_isomeric:
CC(O)=O

# Smiles_String_canonical:
CC(O)=O

# KEGG_Compound_ID:
C00033

# BioCyc_ID:
ACET

# PubChem_CID:
176

# PubChem_SID:
11531946; 11538534; 554954; 10322696; 11528569; 11532670; 11538991; 11538264; 10322371; 11110076; 11531973; 11532070; 11538327; 11109921; 11110411; 10329217; 11538097; 11538202; 11532672; 550783; 10322442; 11448199; 10322636; 11110453; 566666; 11110170; 11538603; 557264; 10322927; 551159; 422198; 11532254; 555448; 554956; 554953; 3133677; 11538917; 11532383; 11538149; 554955; 554858; 11538367; 11110222; 11528326; 11539098; 11448177; 554951; 10322960; 10531526; 11109912; 11109881; 550995; 11532067; 10322507; 11538901; 577279; 550785; 10322836; 550786; 10322416; 550787; 476220; 11532794; 554952; 11539118; 11538538; 11532749; 10322364; 587335; 11538980; 10318536; 10322902; 11538438; 11538597; 550788; 11532554; 149048; 11538478; 10322373; 11532087; 11110245; 11539029; 550784; 551016; 10318673; 11532150; 11539054; 11532347; 11532288; 550782; 10318571; 10322505; 11538998; 557262; 11531941; 10322377; 11531950; 11532418; 10323025; 11538705

# OMIM_ID:
276100; 601705

# Metagene_ID:
HISTIDINEMIA: 181; HYPERPHENYLALANINEMIA DUE TO 6-PTS DEFICIENCY (PTPS): 71; MONOAMINE OXIDASE-A DEFICIENCY (MAO-A): 446; AROMATIC L-AMINO ACID DECARBOXYLASE DEFICIENCY: 354; TYROSINEMIA, TRANSIENT, OF THE NEWBORN: 318; HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY: 133; HYPERPHENYLALANIEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY: 355; BLUE DIAPER SYNDROME: 300; SEPIAPTERIN REDUCTASE DEFICIENCY: 471; KETOSIS, UNSPECIFIC [DD]: 279; DOPA-RESPONSIVE DYSTONIA: 451; PHENYLKETONURIA (PKU): 135; HAWKINSINURIA: 176; ARTEFACTS-BACTERIAL CONTAMINATION, EXCRETION OF ORGANIC ACIDS (ARTEFACTS) [DD]: 348; TYROSINEMIA III: 319; TYROSINEMIA I: 49; TYROSINEMIA II: 66; HARTNUP DISEASE. BEHAVIORAL DISTURBANCES, REVERSIBLE: 175; BETA-KETOTHIOLASE DEFICIENCY: 5

# BiGG_ID:
33590

# Wikipedia_ID:
Acetic acid

# METLIN_ID:
3206

# Ref_ID:
16005905; 12097436; 17060763; 16139280; 15627241; 7762816; 16029568; 7294941; 1931558; 16101231; 16086249; 16101165; 16314038

# ChEBI_ID:
15366

# CAS_Registry_Number:
64-19-7

# InChI:
InChI=1/C2H4O2/c1-2(3)4/h1H3,(H,3,4)

# Synthesis_Reference:
A new hydroxybenzoic acid.     Emmerling, O.; Oppenheim, A.    Berl. Univ.-Laborat.,  Germany.    Berichte der Deutschen Chemischen Gesellschaft  (1876),  9  326-332.

# Melting_Point:
16.6 oC

# Melting_Point_predicted:
19.4 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1000.0 mg/mL [MERCK INDEX (1996)]

# H2O_Solubility_Predicted:
323.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Liquid

# LogP:
-0.17 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-0.12 [Predicted by ALOGPS]; -0.1 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00042_msds.html:::1132562192898992873

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Acetic_acid.mol:::1132723803046998461

# SDF_File_[Text]:
tbl_chemical:::HMDB00042.sdf:::119283149735732402

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00042.pdb:::119283149872337478

# PDB_ID:
1AT5

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1AT5.txt:::1132720899671846606

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041201_P04_17_BA_1DP_presat.png:::114684438290356775

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041201_P04_17_BA_1DP_presat.zip:::114684438301265950

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041201_P04_17_BA_1DP_Assigned.png:::114684438307190719

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::041201_P04_17_BA_1DC_132.jpg:::114174734655214379

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041201_P04_17_BA_1DC_132.zip:::114174734661173899

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041201_P04_17_BA_1DC_132_Assigned.jpg:::114322759700291878

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041201_P04_17_BA_2DHSQC_519.jpg:::114617685182812404

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041201_P04_17_BA_2DHSQC_519.zip:::114617685183640505

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041201_P04_17_BA_2DHSQC_519_Assigned.PNG:::114781086158954728

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Acetic acid.gif:::1132732101781948

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00042_peaks.txt:::1156309505964703243

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Acetic acid_C.gif:::1132737665148471780

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00042_peaks.txt:::115631069760091561

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00042L.png:::11755526538265503; Medium Energy:tbl_ms:::HMDB00042M.png:::117555269955860745; High Energy:tbl_ms:::HMDB00042H.png:::117555272284322625

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000191.png:::116890828448475578

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000191.txt:::116890828468794299

# Cellular_Location:
Cytoplasm (Predicted from LogP); Extracellular; golgi apparatus; mitochondria

# Tissue_Location:
Most Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Feces; Mucus; Saliva; Urine

# Concentration_[Normal]:
Blood	47.7 +/- 50.6	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	2.61 +/- 0.08	umol/L	Adult:>18_yrs_old	Both	Normal	17544838
Cerebrospinal_Fluid(CSF)	116.0 +/- 55.0	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	100.0 +/- 30.0	umol/L	Adult:>18_yrs_old	N/A	Normal	1931558
Cerebrospinal_Fluid(CSF)	284.0 +/- 126.0	uM	Children:1-13_yrs_old	Both	Normal	15627241
Cerebrospinal_Fluid(CSF)	219.0 +/- 109.0	uM	Adult:>18_yrs_old	Both	Normal	HMP Experimental
Saliva	169200.0 (31400.0-307000.0)	uM	Adult:>18_yrs_old	Both	Normal	12097436


# Concentration_[Abnormal]:
Urine	53.0 +/- 71.0	umol/mmol_creatinine	N/A	Both	Lung Cancer	
Cerebrospinal_Fluid(CSF)	35.3 - 211.7	uM	Adult:>18_yrs_old	N/A	Multiple sclerosis	17611627


# Associated_Disorders:
Barrett's Esophagus; Blue Diaper Syndrome; Lung Cancer; Multiple sclerosis; Neoplasia; Prostate Cancer; Spina bifida

# Pathway_Names:
Glycerophospholipid metabolism;Glycolysis;Fatty acid metabolism;Bile acid biosynthesis;Valine, leucine and isoleucine degradation;Lysine degradation;Glycerolipid metabolism;Pyruvate metabolism;Propanoate metabolism;Butanoate metabolism;Reductive carboxylate cycle (CO2 fixation);Benzoate degradation via CoA ligation;Alanine and aspartate metabolism;gamma-Hexachlorocyclohexane degradation;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
;Glycolysis.jpg;;;valine,leucine,and_isoleucine_degradation.jpg;Lysine_degradation.jpg;;;;;;;Aspartate_and_Alanine_metabolism.jpg;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00564;map00010;map00071;map00120;map00280;map00310;map00561;map00620;map00640;map00650;map00720;map00632;map00252;map00361;map00280;map00280

# Pathway_Graphs:
;Glycolysis_Graph.jpg;;;valine,leucine,and_isoleucine_degradation_Graph.jpg;Lysine_degradation_Graph.jpg;;;;;;;Aspartate_and_Alanine_metabolism_Graph.jpg;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
;Glycolysis.xml;;;valine,leucine,and_isoleucine_degradation.xml;Lysine_degradation.xml;;;;;;;Aspartate_and_Alanine_metabolism.xml;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5771

# Metabolic_Enzyme_1_Name:
Platelet-activating factor acetylhydrolase precursor

# Metabolic_Enzyme_1_Synonyms:
PAF acetylhydrolase; PAF 2-acylhydrolase; LDL-associated phospholipase A2; LDL-PLA(2; 2-acetyl-1-alkylglycerophosphocholine esterase; 1-alkyl-2-acetylglycerophosphocholine esterase

# Metabolic_Enzyme_1_Gene_Name:
PLA2G7

# Metabolic_Enzyme_1_Protein_Sequence:
>Plateletactivating factor acetylhydrolase precursor
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN

# Metabolic_Enzyme_1_Number_of_Residues:
441

# Metabolic_Enzyme_1_Molecular_Weight:
50078

# Metabolic_Enzyme_1_Theoretical_pI:
7.61

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  1-alkyl-2-acetylglycerophosphocholine esterase activity
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  lipid catabolism
 ||
>>>
Component:  protein complex
Component:  unlocalized protein complex
Component:  2-acetyl-1-alkylglycerophosphocholine esterase complex

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids

# Metabolic_Enzyme_1_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_1_Reaction:
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF03403:PAF-AH_p_II

# Metabolic_Enzyme_1_Signals:
1-21

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.1.1.47

# Metabolic_Enzyme_1_GenBank_ID_Protein:
780133

# Metabolic_Enzyme_1_SwissProt_ID:
PAFA_HUMAN (Q13093)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
PLA2G7

# Metabolic_Enzyme_1_Geneatlas_id:
PLA2G7

# Metabolic_Enzyme_1_hgnc_id:
HGNC:9040

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_1_Gene_Sequence:
>1326 bp
ATGGTGCCACCCAAATTGCATGTGCTTTTCTGCCTCTGCGGCTGCCTGGCTGTGGTTTAT
CCTTTTGACTGGCAATACATAAATCCTGTTGCCCATATGAAATCATCAGCATGGGTCAAC
AAAATACAAGTACTGATGGCTGCTGCAAGCTTTGGCCAAACTAAAATCCCCCGGGGAAAT
GGGCCTTATTCCGTTGGTTGTACAGACTTAATGTTTGATCACACTAATAAGGGCACCTTC
TTGCGTTTATATTATCCATCCCAAGATAATGATCGCCTTGACACCCTTTGGATCCCAAAT
AAAGAATATTTTTGGGGTCTTAGCAAATTTCTTGGAACACACTGGCTTATGGGCAACATT
TTGAGGTTACTCTTTGGTTCAATGACAACTCCTGCAAACTGGAATTCCCCTCTGAGGCCT
GGTGAAAAATATCCACTTGTTGTTTTTTCTCATGGTCTTGGGGCATTCAGGACACTTTAT
TCTGCTATTGGCATTGACCTGGCATCTCATGGGTTTATAGTTGCTGCTGTAGAACACAGA
GATAGATCTGCATCTGCAACTTACTATTTCAAGGACCAATCTGCTGCAGAAATAGGGGAC
AAGTCTTGGCTCTACCTTAGAACCCTGAAACAAGAGGAGGAGACACATATACGAAATGAG
CAGGTACGGCAAAGAGCAAAAGAATGTTCCCAAGCTCTCAGTCTGATTCTTGACATTGAT
CATGGAAAGCCAGTGAAGAATGCATTAGATTTAAAGTTTGATATGGAACAACTGAAGGAC
TCTATTGATAGGGAAAAAATAGCAGTAATTGGACATTCTTTTGGTGGAGCAACGGTTATT
CAGACTCTTAGTGAAGATCAGAGATTCAGATGTGGTATTGCCCTGGATGCATGGATGTTT
CCACTGGGTGATGAAGTATATTCCAGAATTCCTCAGCCCCTCTTTTTTATCAACTCTGAA
TATTTCCAATATCCTGCTAATATCATAAAAATGAAAAAATGCTACTCACCTGATAAAGAA
AGAAAGATGATTACAATCAGGGGTTCAGTCCACCAGAATTTTGCTGACTTCACTTTTGCA
ACTGGCAAAATAATTGGACACATGCTCAAATTAAAGGGAGACATAGATTCAAATGTAGCT
ATTGATCTTAGCAACAAAGCTTCATTAGCATTCTTACAAAAGCATTTAGGACTTCATAAA
GATTTTGATCAGTGGGACTGCTTGATTGAAGGAGATGATGAGAATCTTATTCCAGGGACC
AACATTAACACAACCAATCAACACATCATGTTACAGAACTCTTCAGGAATAGAGAAATAC
AATTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U20157

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_1_Locus:
6p21.2-p12

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
7700381; 8624782; 7592717; 8675689; 9245731; 9412624; 9472966; 9759612; 10733466

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5527

# Metabolic_Enzyme_2_Name:
Aldehyde dehydrogenase, dimeric NADP-preferring

# Metabolic_Enzyme_2_Synonyms:
ALDH class 3; ALDHIII

# Metabolic_Enzyme_2_Gene_Name:
ALDH3A1

# Metabolic_Enzyme_2_Protein_Sequence:
>Aldehyde dehydrogenase, dimeric NADPpreferring
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH

# Metabolic_Enzyme_2_Number_of_Residues:
453

# Metabolic_Enzyme_2_Molecular_Weight:
50380

# Metabolic_Enzyme_2_Theoretical_pI:
6.52

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes

# Metabolic_Enzyme_2_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_2_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
178402

# Metabolic_Enzyme_2_SwissProt_ID:
AL3A1_HUMAN (P30838)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ALDH3A1

# Metabolic_Enzyme_2_Geneatlas_id:
ALDH3A1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:405

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1362 bp
ATGAGCAAGATCAGCGAGGCCGTGAAGCGCGCCCGCGCCGCCTTCAGCTCGGGCAGGACC
CGTCCGCTGCAGTTCCGATTCCAGCAGCTGGAGGCGCTGCAGCGCCTGATCCAGGAGCAG
GAGCAGGAGCTGGTGGGCGCGCTGGCCGCAGACCTGCACAAGAATGAATGGAACGCCTAC
TATGAGGAGGTGGTGTACGTCCTAGAGGAGATCGAGTACATGATCCAGAAGCTCCCTGAG
TGGGCCGCGGATGAGCCCGTGGAGAAGACGCCCCAGACTCAGCAGGACGAGCTCTACATC
CACTCGGAGCCACTGGGCGTGGTCCTCGTCATTGGCACCTGGAACTACCCCTTCAACCTC
ACCATCCAGCCCATGGTGGGCGCCATCGCTGCAGGGAACGCAGTGGTCCTCAAGCCCTCG
GAGCTGAGTGAGAACATGGCGAGCCTGCTGGCTACCATCATCCCCCAGTACCTGGACAAG
GATCTGTACCCAGTAATCAATGGGGGTGTCCCTGAGACCACGGAGCTGCTCAAGGAGAGG
TTCGACCATATCCTGTACACGGGCAGCACGGGGGTGGGGAAGATCATCATGACGGCTGCT
GCCAAGCACCTGACCCCTGTCACGCTGGAGCTGGGAGGGAAGAGTCCCTGCTACGTGGAC
AAGAACTGTGACCTGGACGTGGCCTGCCGACGCATCGCCTGGGGGAAATTCATGAACAGT
GGCCAGACCTGCGTGGCCCCAGACTACATCCTCTGTGACCCCTCGATCCAGAACCAAATT
GTGGAGAAGCTCAAGAAGTCACTGAAAGAGTTCTACGGGGAAGATGCTAAGAAATCCCGG
GACTATGGAAGAATCATTAGTGCCCGGCACTTCCAGAGGGTGATGGGCCTGATTGAGGGC
CAGAAGGTGGCTTATGGGGGCACCGGGGATGCCGCCACTCGCTACATAGCCCCCACCATC
CTCACGGACGTGGACCCCCAGTCCCCGGTGATGCAAGAGGAGATCTTCGGGCCTGTGCTG
CCCATCGTGTGCGTGCGCAGCCTGGAGGAGGCCATCCAGTTCATCAACCAGCGTGAGAAG
CCCCTGGCCCTCTACATGTTCTCCAGCAACGACAAGGTGATTAAGAAGATGATTGCAGAG
ACATCCAGTGGTGGGGTGGCGGCCAACGATGTCATCGTCCACATCACCTTGCACTCTCTG
CCCTTCGGGGGCGTGGGGAACAGCGGCATGGGATCCTACCATGGCAAGAAGAGCTTCGAG
ACTTTCTCTCACCGCCGCTCTTGCCTGGTGAGGCCTCTGATGAATGATGAAGGCCTGAAG
GTCAGATACCCCCCGAGCCCGGCCAAGATGACCCAGCACTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M74542

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_2_Locus:
17p11.2

# Metabolic_Enzyme_2_SNPs:
rs887241; rs2228100; rs3744692; rs2072330; rs4646787; rs1042183; rs917520; rs4646789; rs4646788; rs3786036; rs887240; rs2072329; rs4646790; rs3744693; rs9895030; rs3826507; rs3744695; rs3744694; rs2072328; rs1006556; rs4319825; rs1042172; rs11554977; rs11554978; rs11554975; rs11554974; rs34474118; rs3786037; rs35473971; rs4646792; rs35116940; rs4646791; rs35853488; rs887239; rs28531080; rs7216299; rs35009373; rs3786035; rs11385990; rs35308039; rs35128135; rs35885485; rs28552545; rs34438543; rs1006553; rs11650088; rs11651480; rs11870332; rs12948881; rs12949049; rs12951039; rs16960382; rs16960386; rs17793620; rs1989379; rs2016823; rs2052052; rs2072327; rs2108967; rs3760485; rs3760486; rs3760487; rs4646783; rs4646784; rs4646785; rs4646786; rs4924793; rs4925046; rs7214841; rs7221211; rs7225305; rs8075157; rs9898715; rs9900430

# Metabolic_Enzyme_2_General_References:
1737758; 8493892; 2037078; 9250352

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5528

# Metabolic_Enzyme_3_Name:
Alpha-aminoadipic semialdehyde dehydrogenase

# Metabolic_Enzyme_3_Synonyms:
Alpha-AASA dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenease; P6c dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1

# Metabolic_Enzyme_3_Gene_Name:
ALDH7A1

# Metabolic_Enzyme_3_Protein_Sequence:
>Alphaaminoadipic semialdehyde dehydrogenase
MSTLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADY
EETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQ
EYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIA
MICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVN
LLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQ
RCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEA
KKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWN
NEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRES
GSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ

# Metabolic_Enzyme_3_Number_of_Residues:
511

# Metabolic_Enzyme_3_Molecular_Weight:
55367

# Metabolic_Enzyme_3_Theoretical_pI:
6.86

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H

# Metabolic_Enzyme_3_Pathway:
map00300  Lysine biosynthesis;
 map00310  Lysine degradation

# Metabolic_Enzyme_3_Reaction:
L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.2.1.31

# Metabolic_Enzyme_3_GenBank_ID_Protein:
797410

# Metabolic_Enzyme_3_SwissProt_ID:
AL7A1_HUMAN (P49419)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ALDH7A1

# Metabolic_Enzyme_3_Geneatlas_id:
ALDH7A1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:877

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>1536 bp
ATGTCCACTCTCCTCATCAATCAGCCCCAGTATGCGTGGCTGAAAGAGCTGGGGCTCCGC
GAGGAAAACGAGGGCGTGTATAATGGAAGCTGGGGAGGCCGGGGAGAGGTTATTACGACC
TATTGCCCCGCTAACAACGAGCCAATAGCAAGAGTCCGACAGGCCAGTGTGGCAGACTAT
GAAGAAACTGTAAAGAAAGCAAGAGAAGCATGGAAAATCTGGGCAGATATTCCTGCTCCA
AAACGAGGAGAAATAGTAAGACAGATTGGCGATGCCTTGCGGGAGAAGATCCAAGTACTA
GGAAGCTTGGTGTCTTTGGAGATGGGGAAAATCTTAGTGGAAGGTGTGGGTGAAGTTCAG
GAGTATGTGGATATCTGTGACTATGCTGTTGGTTTATCAAGGATGATTGGAGGACCTATC
TTGCCTTCTGAAAGATCTGGCCATGCACTGATTGAGCAGTGGAATCCCGTAGGCCTGGTT
GGAATCATCACGGCATTCAATTTCCCTGTGGCAGTGTATGGTTGGAACAACGCCATCGCC
ATGATCTGTGGAAATGTCTGCCTCTGGAAAGGAGCTCCAACCACTTCCCTCATTAGTGTG
GCTGTCACAAAGATAATAGCCAAGGTTCTGGAGGACAACAAGCTGCCTGGTGCAATTTGT
TCCTTGACTTGTGGTGGAGCAGATATTGGCACAGCAATGGCCAAAGATGAACGAGTGAAC
CTGCTGTCCTTCACTGGGAGCACTCAGGTGGGAAAACAGGTGGGCCTGATGGTGCAGGAG
AGGTTTGGGAGAAGTCTGTTGGAACTTGGAGGAAACAATGCCATTATTGCCTTTGAAGAT
GCAGACCTCAGCTTAGTTGTTCCATCAGCTCTCTTCGCTGCTGTGGGAACAGCTGGCCAG
AGGTGTACCACTGCGAGGCGACTGTTTATACATGAAAGCATCCATGATGAGGTTGTAAAC
AGACTTAAAAAGGCCTATGCACAGATCCGAGTTGGGAACCCATGGGACCCTAATGTTCTC
TATGGGCCACTCCACACCAAGCAGGCAGTGAGCATGTTTCTTGGAGCAGTGGAAGAAGCA
AAGAAAGAAGGTGGCACAGTGGTCTATGGGGGCAAGGTTATGGATCGCCCTGGAAATTAT
GTAGAACCGACAATTGTGACAGGTCTTGGCCACGATGCGTCCATTGCACACACAGAGACT
TTCGCTCCGATTCTCTATGTCTTTAAATTCAAGAATGAAGAAGAGGTCTTTGCATGGAAT
AATGAAGTAAAACAGGGACTTTCAAGTAGCATCTTTACCAAAGATCTGGGCAGAATCTTT
CGCTGGCTTGGACCTAAAGGATCAGACTGTGGCATTGTAAATGTCAACATTCCAACAAGT
GGGGCTGAGATTGGAGGTGCCTTTGGAGGAGAAAAGCACACTGGTGGTGGCAGGGAGTCT
GGCAGTGATGCCTGGAAACAGTACATGAGAAGGTCTACTTGTACTATCAACTACAGTAAA
GACCTTCCTCTGGCCCAAGGAATCAAGTTTCAGTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
S74728

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_3_Locus:
5q31

# Metabolic_Enzyme_3_SNPs:
rs12514417; rs2306618; rs2775; rs1038381; rs6595719; rs4835912; rs1038378; rs1038380; rs2306617; rs4379190; rs4836276; rs11241901; rs4240406; rs12513847; rs7709115; rs4836272; rs7713264; rs6870785; rs11241902; rs7714044; rs1038379; rs10050642; rs7723008; rs4836277; rs3734175; rs6898430; rs17154671; rs4626334; rs13182402; rs17154679; rs4835914; rs12653605; rs2306619; rs7719675; rs10478743; rs7700981; rs2035472; rs11241903; rs6861395; rs7724875; rs2291295; rs10519915; rs7719712; rs6898559; rs4626335; rs17154676; rs11952752; rs13179664; rs4835913; rs11742214; rs3734174; rs11742381; rs7736031; rs7737529; rs10478744; rs4836275; rs17154666; rs34241005; rs10043987; rs7718426; rs2013986; rs10067785; rs7719091; rs17165056; rs13188450; rs900645; rs7708281; rs7703958; rs7723494; rs10050872; rs7702811; rs13171814; rs6897789; rs13177576; rs7704283; rs4526102; rs11741551; rs10038571; rs4836273; rs3736174; rs3736171; rs1483780; rs900641; rs744722; rs900640; rs7718710; rs1060856; rs744720; rs17165061; rs744721; rs1807; rs6865317; rs6884473; rs7447092; rs3189320; rs1049217; rs1049211; rs11542969; rs1049214; rs11269202; rs6898845; rs35027610; rs35284915; rs34275373; rs35570062; rs34674137; rs28429591; rs7730016; rs4612066; rs36058537; rs2408702; rs11406545; rs1142071; rs13356526; rs35492150; rs34697893; rs10539406; rs34825424; rs7703752; rs12187161; rs34949719; rs36125577; rs36077292; rs7719949; rs35736560; rs34201518; rs33926729; rs34250591; rs13185811; rs34323751; rs34907915; rs28865092; rs35559498; rs35109136; rs10630162; rs4836274; rs34972014; rs13173864; rs7709981; rs6870070; rs2408703; rs35118533; rs10532390; rs34517958; rs34069611; rs10629966; rs7706009; rs34496788; rs34935903; rs35115612; rs13174679; rs10609859; rs34995966; rs34074703; rs36120385; rs34424711; rs34537297; rs7737783; rs35457522; rs35367836; rs36017518; rs17597559; rs7730933; rs33954485; rs35196030; rs35930104; rs34575294; rs10666972; rs10676689; rs35010266; rs34035179; rs28629815; rs7704352; rs35797169; rs10044223; rs35622239; rs35960414; rs34959052; rs35342756; rs13154789; rs4836278; rs35617751; rs34731336; rs12656014; rs34305021; rs34684581; rs5871220; rs11951146; rs35290920; rs13166319; rs2408633; rs11290126; rs34862437; rs35992646; rs35110442; rs10609860; rs11742868; rs6896807; rs17531712; rs34770295; rs3080835; rs11387172; rs7737256; rs34601459; rs9765047; rs1060857; rs3736172; rs11458774; rs1138001; rs7447380; rs5871218; rs1138005; rs34410568; rs3736173; rs35569843; rs744723; rs5871219; rs34450389; rs34135005; rs3830274; rs11750167; rs1384880; rs17154635; rs2035471; rs2128931; rs2306620; rs2306621; rs2306622; rs2408700; rs28365789; rs3734173; rs4240405; rs4597966; rs4835911; rs4836271; rs6882015; rs730870; rs7715516; rs7726892

# Metabolic_Enzyme_3_General_References:
8088832; 9417906

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5785

# Metabolic_Enzyme_4_Name:
Platelet-activating factor acetylhydrolase 2, cytoplasmic

# Metabolic_Enzyme_4_Synonyms:
Serine-dependent phospholipase A2; HSD-PLA2

# Metabolic_Enzyme_4_Gene_Name:
PAFAH2

# Metabolic_Enzyme_4_Protein_Sequence:
>Plateletactivating factor acetylhydrolase 2, cytoplasmic
MGVNQSVGFPPVTGPHLVGCGDVMEGQNLQGSFFRLFYPCQKAEETMEQPLWIPRYEYCT
GLAEYLQFNKRCGGLLFNLAVGSCRLPVSWNGPFKTKDSGYPLIIFSHGLGAFRTLYSAF
CMELASRGFVVAVPEHRDRSAATTYFCKQAPEENQPTNESLQEEWIPFRRVEEGEKEFHV
RNPQVHQRVSECLRVLKILQEVTAGQTVFNILPGGLDLMTLKGNIDMSRVAVMGHSFGGA
TAILALAKETQFRCAVALDAWMFPLERDFYPKARGPVFFINTEKFQTMESVNLMKKICAQ
HEQSRIITVLGSVHRSQTDFAFVTGNLIGKFFSTETRGSLDPYEGQEVMVRAMLAFLQKH
LDLKEDYNQWNNLIEGIGPSLTPGAPHHLSSL

# Metabolic_Enzyme_4_Number_of_Residues:
392

# Metabolic_Enzyme_4_Molecular_Weight:
44036

# Metabolic_Enzyme_4_Theoretical_pI:
6.89

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  1-alkyl-2-acetylglycerophosphocholine esterase activity
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  lipid catabolism
 ||
>>>
Component:  protein complex
Component:  unlocalized protein complex
Component:  2-acetyl-1-alkylglycerophosphocholine esterase complex

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme

# Metabolic_Enzyme_4_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_4_Reaction:
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF03403:PAF-AH_p_II

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.1.1.47

# Metabolic_Enzyme_4_GenBank_ID_Protein:
1765864

# Metabolic_Enzyme_4_SwissProt_ID:
PAFA2_HUMAN (Q99487)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
PAFAH2

# Metabolic_Enzyme_4_Geneatlas_id:
PAFAH2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:8579

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_4_Gene_Sequence:
>1179 bp
ATGGGGGTCAACCAGTCTGTGGGCTTTCCACCTGTCACAGGACCCCACCTCGTAGGCTGT
GGGGATGTGATGGAGGGTCAGAATCTCCAGGGGAGCTTCTTTCGACTCTTCTACCCCTGC
CAAAAGGCAGAGGAGACCATGGAGCAGCCCCTGTGGATTCCCCGCTATGAGTACTGCACT
GGCCTGGCCGAGTACCTGCAGTTTAATAAGCGCTGCGGGGGCTTGCTGTTCAACCTGGCG
GTGGGATCTTGTCGCCTGCCTGTTAGCTGGAATGGCCCCTTTAAGACAAAGGACTCTGGA
TACCCCTTGATCATCTTCTCCCATGGCCTAGGAGCCTTCAGGACTTTGTATTCAGCCTTC
TGCATGGAGCTGGCCTCACGTGGCTTTGTGGTTGCTGTGCCAGAGCACAGGGACCGGTCA
GCGGCAACCACCTATTTCTGCAAGCAGGCCCCAGAAGAGAACCAGCCCACCAATGAATCG
CTGCAGGAGGAATGGATCCCTTTCCGTCGAGTTGAGGAAGGGGAGAAGGAATTTCATGTT
CGGAATCCCCAGGTGCATCAGCGGGTAAGCGAGTGTTTACGGGTGTTGAAGATCCTGCAA
GAGGTCACTGCTGGGCAGACTGTCTTCAACATCTTGCCTGGTGGCTTGGATCTGATGACT
TTGAAGGGCAACATTGACATGAGCCGTGTGGCTGTGATGGGACATTCATTTGGAGGGGCC
ACAGCTATTCTGGCTTTGGCCAAGGAGACCCAATTTCGGTGTGCGGTGGCTCTGGATGCT
TGGATGTTTCCTCTGGAACGTGACTTTTACCCCAAGGCCCGAGGACCTGTGTTCTTTATC
AATACTGAGAAATTCCAGACAATGGAGAGTGTCAATTTGATGAAGAAGATATGTGCCCAG
CATGAACAGTCTAGGATCATAACCGTTCTTGGTTCTGTTCATCGGAGTCAAACTGACTTT
GCTTTTGTGACTGGCAACTTGATTGGTAAATTCTTCTCCACTGAAACCCGTGGGAGCCTG
GACCCCTATGAAGGGCAGGAGGTTATGGTACGGGCCATGTTGGCCTTCCTGCAGAAGCAC
CTCGACCTGAAAGAAGACTATAATCAATGGAACAACCTTATTGAAGGCATTGGACCGTCG
CTCACCCCAGGGGCCCCCCACCATCTGTCCAGCCTGTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
D87845

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_4_Locus:
1p34.3

# Metabolic_Enzyme_4_SNPs:
rs34555067; rs1932067; rs12408803; rs3008423; rs11247841; rs2992056; rs6598938; rs11247840; rs6657145; rs2012311; rs933078; rs3738455; rs12042915; rs9438606; rs17163462; rs2992055; rs7355094; rs17163460; rs10794520; rs17163464; rs10794521; rs298442; rs2275102; rs1469511; rs6662751; rs1257156; rs3767929; rs6680265; rs3738458; rs1257155; rs298441; rs4659400; rs1257153; rs10902716; rs1469510; rs298443; rs7553386; rs11247834; rs1429936; rs11581726; rs2275101; rs7543346; rs1469512; rs6683366; rs298449; rs7536067; rs3767928; rs10751732; rs11247839; rs10902715; rs10794519; rs1889605; rs4507998; rs2257255; rs2914970; rs11247838; rs11580136; rs10794518; rs12136909; rs298448; rs1257152; rs12080982; rs298444; rs11247837; rs11582253; rs12565672; rs12030759; rs2245979; rs10902713; rs6696592; rs11247836; rs6598937; rs10902712; rs12240057; rs12138372; rs2039542; rs298445; rs2782814; rs298458; rs2992071; rs34317686; rs12410711; rs35020920; rs35335420; rs11590732; rs34512807; rs34273468; rs35710365; rs4659361; rs11327055; rs3008239; rs35480896; rs12041217; rs12757628; rs35497051; rs34534304; rs35383525; rs6678309; rs34108084; rs34937286; rs11289287; rs35777678; rs11325353; rs2914967; rs2992062; rs12078456; rs35304992; rs2992061; rs3738456; rs298446; rs12035930; rs12079021; rs12128156; rs298447; rs34894360; rs28699515; rs7529111; rs4659399; rs1272735; rs35755086; rs35753945; rs34522205; rs1269087; rs12092409; rs12239959; rs298450; rs4350193; rs12239914; rs34853555; rs35780536; rs34681521; rs5773141; rs10902714; rs9438538; rs3008422; rs34825646; rs34187194; rs35865072; rs35581219; rs35627679; rs12136914; rs35319124; rs2782821; rs182439; rs1257154; rs3008410; rs2914968; rs28757614; rs11247835; rs34882050; rs2992060; rs12406618; rs35441797; rs3008421; rs28433155; rs11577113; rs34878410; rs35739814; rs41334746; rs35864830; rs34043562; rs10751731; rs11247842; rs12074251; rs12744951; rs2914971; rs298454; rs298456; rs298457; rs2992064; rs3008236; rs3008240; rs3008241; rs3008412; rs35874022; rs4659401; rs5014395

# Metabolic_Enzyme_4_General_References:
8955149; 9494101; 9218411

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5529

# Metabolic_Enzyme_5_Name:
Aldehyde dehydrogenase 1A3

# Metabolic_Enzyme_5_Synonyms:
Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3

# Metabolic_Enzyme_5_Gene_Name:
ALDH1A3

# Metabolic_Enzyme_5_Protein_Sequence:
>Aldehyde dehydrogenase 1A3
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI
CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM
DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW
NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV
GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE
CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK
QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL
KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF
KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP

# Metabolic_Enzyme_5_Number_of_Residues:
512

# Metabolic_Enzyme_5_Molecular_Weight:
56109

# Metabolic_Enzyme_5_Theoretical_pI:
7.29

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_5_Specific_Function:
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system

# Metabolic_Enzyme_5_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_5_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_5_GenBank_ID_Protein:
544482

# Metabolic_Enzyme_5_SwissProt_ID:
AL1A3_HUMAN (P47895)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ALDH1A3

# Metabolic_Enzyme_5_Geneatlas_id:
ALDH1A3

# Metabolic_Enzyme_5_hgnc_id:
HGNC:409

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1539 bp
ATGGCCACCGCTAACGGGGCCGTGGAAAACGGGCAGCCGGACGGGAAGCCGCCGGCCCTG
CCGCGCCCCATCCGCAACCTGGAGGTCAAGTTCACCAAGATATTTATCAACAATGAATGG
CACGAATCCAAGAGTGGGAAAAAGTTTGCTACATGTAACCCTTCAACTCGGGAGCAAATA
TGTGAAGTGGAAGAAGGAGATAAGCCCGACGTGGACAAGGCTGTGGAGGCTGCACAGGTT
GCCTTCCAGAGGGGCTCGCCATGGCGCCGGCTGGATGCCCTGAGTCGTGGGCGGCTGCTG
CACCAGCTGGCTGACCTGGTGGAGAGGGACCGCGCCACCTTGGCCGCCCTGGAGACGATG
GATACAGGGAAGCCATTTCTTCATGCTTTTTTCATCGACCTGGAGGGCTGTATTAGAACC
CTCAGATACTTTGCAGGGTGGGCAGACAAAATCCAGGGCAAGACCATCCCCACAGATGAC
AACGTCGTATGCTTCACCAGGCATGAGCCCATTGGTGTCTGTGGGGCCATCACTCCATGG
AACTTCCCCCTGCTGATGCTGGTGTGGAAGCTGGCACCCGCCCTCTGCTGTGGGAACACC
ATGGTCCTGAAGCCTGCGGAGCAGACACCTCTCACCGCCCTTTATCTCGGCTCTCTGATC
AAAGAGGCCGGGTTCCCTCCAGGAGTGGTGAACATTGTGCCAGGATTCGGGCCCACAGTG
GGAGCAGCAATTTCTTCTCACCCTCAGATCAACAAGATCGCCTTCACCGGCTCCACAGAG
GTTGGAAAACTGGTTAAAGAAGCTGCGTCCCGGAGCAATCTGAAGCGGGTGACGCTGGAG
CTGGGGGGGAAGAACCCCTGCATCGTGTGTGCGGACGCTGACTTGGACTTGGCAGTGGAG
TGTGCCCATCAGGGAGTGTTCTTCAACCAAGGCCAGTGTTGCACGGCAGCCTCCAGGGTG
TTCGTGGAGGAGCAGGTCTACTCTGAGTTTGTCAGGCGGAGCGTGGAGTATGCCAAGAAA
CGGCCCGTGGGAGACCCCTTCGATGTCAAAACAGAACAGGGGCCTCAGATTGATCAAAAG
CAGTTCGACAAAATCTTAGAGCTGATCGAGAGTGGGAAGAAGGAAGGGGCCAAGCTGGAA
TGCGGGGGCTCAGCCATGGAAGACAAGGGGCTCTTCATCAAACCCACTGTCTTCTCAGAA
GTCACAGACAACATGCGGATTGCCAAAGAGGAGATTTTCGGGCCAGTGCAACCAATACTG
AAGTTCAAAAGTATCGAAGAAGTGATAAAAAGAGCGAATAGCACCGACTATGGACTCACA
GCAGCCGTGTTCACAAAAAATCTCGACAAAGCCCTGAAGTTGGCTTCTGCCTTAGAGTCT
GGAACGGTCTGGATCAACTGCTACAACGCCCTCTATGCACAGGCTCCATTTGGTGGCTTT
AAAATGTCAGGAAATGGCAGAGAACTAGGTGAATACGCTTTGGCCGAATACACAGAAGTG
AAAACTGTCACCATCAAACTTGGCGACAAGAACCCCTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U07919

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_5_Locus:
15q26.3

# Metabolic_Enzyme_5_SNPs:
rs3803430; rs2229183; rs1130738; rs14226; rs3803424; rs7045; rs3803426; rs7182089; rs4646690; rs7161860; rs4246328; rs4646688; rs4646668; rs4646670; rs3803428; rs4646671; rs6598396; rs4646675; rs9944290; rs7181897; rs4646684; rs4246323; rs4246327; rs4246329; rs4646674; rs8039374; rs4646678; rs4646653; rs4646655; rs7182884; rs3809521; rs11854028; rs3825926; rs3803433; rs6598397; rs4646662; rs4646685; rs4646651; rs4646672; rs3922685; rs4646654; rs3902902; rs4646683; rs7176046; rs3803432; rs4246324; rs4646661; rs8030776; rs12903828; rs4646687; rs4646680; rs3825925; rs7178221; rs3803427; rs7170197; rs4246325; rs8023972; rs4646681; rs7167278; rs4246326; rs1886; rs4646649; rs12908902; rs7171776; rs3803429; rs12914598; rs4646669; rs4646650; rs3803434; rs4646660; rs4646682; rs3809524; rs3809523; rs3809526; rs7179268; rs1130737; rs3803431; rs1130768; rs34302490; rs28760343; rs35300460; rs1802602; rs1802604; rs4288979; rs3803425; rs1802603; rs4646663; rs28691047; rs28731371; rs34655770; rs35165034; rs28509297; rs10400871; rs35129664; rs12905372; rs28405557; rs34486175; rs28546254; rs35055541; rs4646686; rs28441320; rs28410143; rs4646676; rs4646648; rs8029933; rs12910188; rs34182689; rs28504296; rs28449981; rs28507582; rs3825927; rs35310246; rs12910025; rs28384196; rs4343265; rs12910662; rs8028283; rs28475530; rs4392045; rs28369514; rs28377287; rs8035722; rs28480133; rs28707102; rs28583888; rs4646666; rs7173413; rs28472416; rs28673034; rs28668881; rs28711429; rs34837038; rs4646659; rs28452487; rs28712665; rs12910029; rs12902704; rs4646673; rs28689536; rs28431101; rs34431941; rs7178645; rs28454526; rs7170202; rs1889; rs4646647; rs4375646; rs11348272; rs4646656; rs28408085; rs28699556; rs28615197; rs28539744; rs28557216; rs28631565; rs34302839; rs3923499; rs4646664; rs35740226; rs28385499; rs3922686; rs28474807; rs28490217; rs12909825; rs10593974; rs28679806; rs28610999; rs7178553; rs35519561; rs35831758; rs35526807; rs4646658; rs28538652; rs28685242; rs10400842; rs4646667; rs35948146; rs4646677; rs7165217; rs10400872; rs28750207; rs3825924; rs7171453; rs34906846; rs4646665; rs9920154; rs36081993; rs11435500; rs28464660; rs4646679; rs12595234; rs4646689; rs3809522; rs35950557; rs3809527; rs7172149; rs7178931; rs8034153; rs7183889; rs3809525; rs4646646; rs11630601; rs11630691; rs11632820; rs11637204; rs11854709; rs12148466; rs12148493; rs12440023; rs12593839; rs12901792; rs12907776; rs12908105; rs12909230; rs12909791; rs28507591; rs3803435; rs4346184; rs4646694; rs7163108; rs7164136; rs7181644; rs8034686; rs8035036

# Metabolic_Enzyme_5_General_References:
7698756

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5266

# Metabolic_Enzyme_6_Name:
Acetyl-coenzyme A synthetase, cytoplasmic

# Metabolic_Enzyme_6_Synonyms:
Acetate--CoA ligase; Acyl-activating enzyme; Acetyl-CoA synthetase; ACS; AceCS; Acyl-CoA synthetase short-chain family member 2

# Metabolic_Enzyme_6_Gene_Name:
ACSS2

# Metabolic_Enzyme_6_Protein_Sequence:
>Acetylcoenzyme A synthetase, cytoplasmic
MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPRE
FWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDK
VAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLAC
ARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK
GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDEC
EPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIG
WITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFG
DEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPG
ATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTY
FKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVV
GHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSG
KIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ

# Metabolic_Enzyme_6_Number_of_Residues:
701

# Metabolic_Enzyme_6_Molecular_Weight:
78580

# Metabolic_Enzyme_6_Theoretical_pI:
6.43

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  AMP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-sulfur bonds
Function:  CoA-ligase activity
Function:  acetate-CoA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Activates acetate so that it can be used for lipid synthesis or for energy generation

# Metabolic_Enzyme_6_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_6_Reaction:
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 6.2.1.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
8439651

# Metabolic_Enzyme_6_SwissProt_ID:
ACSA_HUMAN (Q9NR19)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ACSS2

# Metabolic_Enzyme_6_Geneatlas_id:
ACSS2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:15814

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_6_Gene_Sequence:
>2106 bp
ATGGGGCTTCCTGAGGAGCGGGTCCGGAGCGGCAGCGGGAGCCGGGGCCAGGAGGAAGCT
GGAGCCGGAGGCCGGGCGCGGAGTTGGTCTCCGCCGCCCGAGGTCAGCCGCTCCGCGCAC
GTCCCCTCGCTGCAGCGCTACCGCGAGCTGCACCGGCGCTCCGTGGAGGAGCCGCGGGAA
TTCTGGGGAGACATTGCCAAGGAATTTTACTGGAAGACTCCATGCCCTGGCCCATTCCTT
CGGTACAACTTTGATGTGACTAAAGGGAAAATCTTCATTGAGTGGATGAAAGGAGCAACT
ACCAACATCTGCTACAATGTACTGGATCGAAATGTCCATGAGAAAAAGCTTGGAGATAAA
GTTGCTTTTTACTGGGAGGGCAATGAGCCAGGGGAGACCACTCAGATCACATACCATCAG
CTTCTGGTCCAAGTGTGTCAGTTCAGCAATGTTCTCCGAAAACAGGGCATTCAGAAGGGG
GACCGAGTGGCCATCTACATGCCTATGATCCCAGAGCTTGTGGTGGCCATGCTGGCATGT
GCCCGCATTGGGGCTTTGCACTCCATTGTGTTTGCAGGCTTCTCTTCAGAGTCTCTATGT
GAACGGATCTTGGATTCCAGCTGCAGTCTTCTCATCACTACAGATGCCTTCTACAGGGGG
GAAAAGCTTGTGAACCTGAAGGAGCTGGCTGACGAGGCCCTGCAGAAGTGTCAGGAGAAG
GGTTTCCCAGTAAGATGCTGCATTGTGGTCAAGCACCTGGGGCGGGCAGAGCTCGGCATG
GGTGACTCCACCAGCCAGTCCCCCCCAATTAAGAGGTCATGCCCAGATGTGCAGATCTCA
TGGAACCAAGGGATTGACTTGTGGTGGCATGAGCTCATGCAAGAGGCAGGGGATGAGTGT
GAGCCCGAGTGGTGTGATGCCGAGGACCCACTCTTCATCCTGTACACCAGTGGCTCCACA
GGCAAACCCAAGGGTGTGGTTCACACAGTTGGGGGCTACATGCTCTATGTAGCCACAACC
TTCAAGTATGTGTTTGACTTCCATGCAGAGGATGTGTTCTGGTGCACGGCAGACATTGGT
TGGATCACTGGTCATTCCTACGTCACCTATGGGCCACTGGCCAATGGTGCCACCAGTGTT
TTGTTTGAGGGGATTCCCACATATCCGGACGTGAACCGCCTGTGGAGCATTGTGGACAAA
TACAAGGTGACCAAGTTCTACACAGCACCCACAGCCATCCGTCTGCTCATGAAGTTTGGA
GATGAGCCTGTCACCAAGCATAGCCGGGCATCCTTGCAGGTGTTAGGCACAGTGGGTGAA
CCCATCAACCCTGAGGCCTGGCTATGGTACCACCGGGTGGTAGGTGCCCAGCGCTGCCCC
ATCGTGGACACCTTCTGGCAAACAGAGACAGGTGGCCACATGTTGACTCCCCTTCCTGGT
GCCACACCCATGAAACCCGGTTCTGCTACTTTCCCATTCTTTGGTGTAGCTCCTGCAATC
CTGAATGAGTCCGGGGAAGAGTTGGAAGGTGAAGCTGAAGGTTATCTGGTGTTCAAGCAG
CCCTGGCCAGGGATCATGCGCACAGTCTATGGGAACCACGAACGCTTTGAGACAACCTAC
TTTAAGAAGTTTCCTGGATACTATGTTACAGGAGATGGCTGCCAGCGGGACCAGGATGGC
TATTACTGGATCACTGGCAGGATTGATGACATGCTCAATGTATCTGGACACCTGCTGAGT
ACAGCAGAGGTGGAGTCAGCACTTGTGGAACATGAGGCTGTTGCAGAGGCAGCTGTGGTG
GGCCACCCTCATCCTGTGAAGGGTGAATGCCTCTACTGCTTTGTCACCTTGTGTGATGGC
CACACCTTCAGCCCCAAGCTCACCGAGGAGCTCAAGAAGCAGATTAGAGAAAAGATTGGC
CCCATTGCCACACCAGACTACATCCAGAATGCACCTGGCTTGCCTAAAACCCGCTCAGGG
AAAATCATGAGGCGAGTGCTTCGGAAGATTGCTCAGAATGACCATGACCTCGGGGACATG
TCTACTGTGGCTGACCCATCTGTCATCAGTCACCTCTTCAGCCACCGCTGCCTGACCATC
CAGTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AF263614

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_6_Locus:
20q11.22

# Metabolic_Enzyme_6_SNPs:
rs4911163; rs10485507; rs6120750; rs1013677; rs6088635; rs6579198; rs6058135; rs6087642; rs6087641; rs6088638; rs6088636; rs7509557; rs6088650; rs6087644; rs6120758; rs4911164; rs6060112; rs8119110; rs6120763; rs6087649; rs6058137; rs3746450; rs4911447; rs6088640; rs1060615; rs6119542; rs926734; rs8116657; rs4911451; rs6119543; rs6120757; rs4911449; rs6088646; rs2295097; rs6087643; rs2223881; rs6088642; rs8117380; rs2273683; rs8123210; rs11905770; rs2064454; rs2076667; rs12717838; rs3818273; rs3787215; rs2207147; rs6120754; rs4911450; rs7266550; rs4911448; rs2378294; rs8125240; rs2378291; rs17092174; rs2378292; rs6058142; rs6120756; rs3787214; rs6120753; rs17092163; rs17092169; rs6060107; rs6060113; rs2378293; rs8117491; rs6120759; rs6088647; rs17850882; rs6088649; rs4349415; rs13043365; rs2295096; rs34527271; rs13043347; rs35779501; rs3053923; rs35596631; rs6088637; rs8115733; rs7509556; rs2024634; rs11476807; rs6060105; rs11472785; rs2024633; rs11467604; rs6120749; rs35991119; rs1062891; rs2024632; rs11167247; rs17400522; rs11699241; rs11472114; rs36077883; rs13042631; rs34362920; rs35104294; rs6119540; rs11478163; rs6088651; rs2295095; rs9547; rs11299664; rs6142261; rs35620674; rs35540450; rs6060111; rs3054612; rs6120752; rs11479533; rs34171408; rs11425079; rs6142260; rs34872018; rs11697404; rs11481649; rs7268774; rs34951413; rs33930398; rs6087647; rs34277751; rs6119544; rs35456894; rs6120764; rs6087646; rs11476381; rs11479477; rs28878236; rs6142263; rs6058143; rs5841186; rs28802941; rs8119835; rs6058136; rs3054610; rs6120755; rs28434523; rs35234476; rs8184664; rs11474295; rs35208311; rs34525778; rs36108141; rs34213461; rs6142258; rs2378290; rs6088639; rs6060110; rs6088643; rs36102262; rs11699164; rs35470839; rs35962008; rs6142259; rs11421679; rs10542624; rs8183627; rs6142255; rs34682859; rs35504652; rs11474981; rs6060106; rs6060115; rs35655449; rs34939273; rs11482260; rs4588263; rs34590082; rs13038710; rs6120760; rs6058138; rs6058139; rs35212956; rs35067244; rs6088645; rs6060108; rs11483997; rs11477769; rs4600736; rs7260994; rs6142256; rs11479348; rs6120761; rs6141520; rs6087645; rs13044142; rs34680118; rs11481648; rs35773172; rs13339938; rs36019966; rs35404681; rs6142257; rs13038395; rs13040750; rs5841185; rs34109099; rs35829893; rs34032248; rs13041047; rs11476265; rs41287074; rs11469541; rs6088641; rs35102137; rs6142254; rs34578238; rs10554596; rs34807244; rs6119541; rs28694099; rs34675937; rs34401220; rs6120751; rs35359973; rs6060109; rs6060104; rs17309872; rs2064453; rs2236270; rs2236271; rs6060103; rs6087651; rs6088628; rs6088629; rs6088631; rs6088652; rs725521; rs7263157; rs7264920; rs7265109; rs7265992; rs7269682

# Metabolic_Enzyme_6_General_References:
10843999; 11780052

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5811

# Metabolic_Enzyme_7_Name:
Aldehyde dehydrogenase 3B1

# Metabolic_Enzyme_7_Synonyms:
Aldehyde dehydrogenase 7

# Metabolic_Enzyme_7_Gene_Name:
ALDH3B1

# Metabolic_Enzyme_7_Protein_Sequence:
>Aldehyde dehydrogenase 3B1
MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE
VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL
TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR
FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA
GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC
GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK
PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD
TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL

# Metabolic_Enzyme_7_Number_of_Residues:
468

# Metabolic_Enzyme_7_Molecular_Weight:
51840

# Metabolic_Enzyme_7_Theoretical_pI:
7.67

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_7_Specific_Function:
An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

# Metabolic_Enzyme_7_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_7_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_7_GenBank_ID_Protein:
601780

# Metabolic_Enzyme_7_SwissProt_ID:
AL3B1_HUMAN (P43353)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
ALDH3B1

# Metabolic_Enzyme_7_Geneatlas_id:
ALDH3B1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:410

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>1407 bp
ATGGACCCCCTTGGGGACACGCTGCGGCGACTGCGGGAGGCCTTCCACGCGGGGCGCACG
CGGCCAGCTGAGTTCCGGGCTGCGCAGCTCCAAGGCCTGGGCCGCTTCCTGCAAGAAAAC
AAGCAGCTTCTGCACGACGCACTGGCCCAGGACCTGCACAAGTCAGCCTTCGAGTCGGAG
GTGTCTGAGGTTGCCATCAGCCAGGGCGAGGTCACCCTGGCCCTCAGGAACCTCCGGGCC
TGGATGAAGGACGAGCGTGTGCCCAAGAACCTGGCCACGCAGCTGGACTCCGCCTTCATC
CGGAAGGAGCCCTTTGGCCTGGTCCTCATCATTGCGCCCTGGAACTATCCGCTGAACCTG
ACGCTGGTGCCCCTCGTGGGAGCCCTCGCTGCAGGGAACTGTGTGGTGCTGAAGCCATCG
GAGATTAGCAAGAACGTCGAGAAGATCCTGGCCGAGGTGCTGCCCCAATACGTGGACCAG
AGCTGCTTTGCTGTGGTGCTGGGCGGGCCCCAGGAGACGGGGCAGCTGCTAGAGCACAGG
TTCGACTACATCTTCTTCACAGGGAGCCCTCGTGTGGGCAAGATTGTTATGACTGCTGCC
GCCAAGCACCTGACACCTGTCACCCTGGAGCTGGGGGGCAAGAACCCTTGCTACGTGGAC
GACAACTGCGACCCCCAGACCGTGGCCAACCGCGTGGCCTGGTTCCGCTACTTCAACGCC
GGCCAGACCTGCGTGGCCCCCGACTACGTCCTATGCAGCCCTGAGATGCAGGAGAGGCTG
CTGCCTGCCCTGCAGAGCACCATCACCCGTTTCTATGGCGACGACCCCCAGAGCTCCCCA
AACCTGGGCCGCATCATCAACCAGAAACAGTTCCAGCGGCTGCGGGCATTGCTGGGCTGC
GGCCGTGTGGCCATTGGGGGCCAGAGCGATGAGAGCGATCGCTACATCGCCCCCACGGTG
CTGGTGGATGTGCAGGAGATGGAGCCTGTGATGCAGGAGGAGATCTTCGGGCCCATCCTG
CCCATCGTGAACGTGCAGAGCTTGGACGAGGCCATCGAGTTCATCAACCGGCGGGAGAAG
CCCCTGGCCCTGTACGCCTTCTCCAACAGCAGCCAGGTGGTCAAGCGGGTGCTGACCCAG
ACCAGCAGCGGGGGCTTCTGTGGGAACGACGGCTTCATGCACATGACCCTGGCCAGCCTG
CCTTTTGGAGGAGTGGGTGCCAGTGGGATGGGCCGGTACCATGGCAAGTTCTCCTTCGAC
ACCTTCTCCCACCATCGCGCCTGCCTCCTGCGCAGCCCGGGGATGGAGAAGCTCAACGCC
CTCCGCTACCCGCCGCAATCGCCGCGCCGCCTGAGGATGCTGCTGGTGGCCATGGAGGCC
CAAGGCTGCAGCTGCACACTGCTCTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
U10868

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_7_Locus:
11q13

# Metabolic_Enzyme_7_SNPs:
rs572574; rs3764821; rs172620; rs3794181; rs3751081; rs12281209; rs1703440; rs3764818; rs556601; rs2286170; rs1003777; rs308293; rs2286169; rs4646809; rs3764819; rs886702; rs2286163; rs2286164; rs3794177; rs2286165; rs105147; rs2286168; rs2286166; rs308342; rs7125916; rs2286171; rs3794176; rs581105; rs12574760; rs3751082; rs308341; rs34280013; rs475325; rs3764817; rs3751084; rs4244839; rs4646812; rs598156; rs3764816; rs1636207; rs886701; rs11228121; rs308336; rs2010404; rs308335; rs557098; rs308334; rs308338; rs308337; rs3763941; rs737265; rs308333; rs35738719; rs12794336; rs34580830; rs11607185; rs1636208; rs1793238; rs1636209; rs11605214; rs7108283; rs3815220; rs12286110; rs34494820; rs35406834; rs2286167; rs12789057; rs33945294; rs7116695; rs35785905; rs11436139; rs28584816; rs12799330; rs4646808; rs5792429; rs4646813; rs12284146; rs12806003; rs4646811; rs34109111; rs35256233; rs34526809; rs12277180; rs4646810; rs177812; rs34271562; rs8181582; rs11433668; rs7925460; rs34588975; rs34721102; rs7116941; rs3794179; rs12273237; rs34130972; rs5792428; rs7113328; rs34928150; rs7117605; rs35400021; rs11826595; rs1051806; rs1076558; rs10896288; rs1122731; rs11228120; rs11228122; rs11823975; rs11824781; rs11825872; rs12418774; rs12421254; rs12803743; rs1703438; rs1804688; rs191064; rs191065; rs2075626; rs2286172; rs28939679; rs308326; rs308339; rs308340; rs3115545; rs3115546; rs3115548; rs3133266; rs3133267; rs3133269; rs3751085; rs3763942; rs3808969; rs3808970; rs3808971; rs4147776; rs4147777; rs4147778; rs4147780; rs4147782; rs479763; rs7949541; rs7951010; rs7952122; rs884826; rs999571

# Metabolic_Enzyme_7_General_References:
7828891

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5772

# Metabolic_Enzyme_8_Name:
Acetylcholinesterase precursor

# Metabolic_Enzyme_8_Synonyms:
AChE

# Metabolic_Enzyme_8_Gene_Name:
ACHE

# Metabolic_Enzyme_8_Protein_Sequence:
>Acetylcholinesterase precursor
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL

# Metabolic_Enzyme_8_Number_of_Residues:
614

# Metabolic_Enzyme_8_Molecular_Weight:
67797

# Metabolic_Enzyme_8_Theoretical_pI:
6.24

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  cholinesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Rapidly hydrolyzes choline released into the synapse

# Metabolic_Enzyme_8_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_8_Reaction:
acetylcholine + H2O = choline + acetate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF08674:AChE_tetra;
PF00135:COesterase

# Metabolic_Enzyme_8_Signals:
1-31

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.1.1.7

# Metabolic_Enzyme_8_GenBank_ID_Protein:
177975

# Metabolic_Enzyme_8_SwissProt_ID:
ACES_HUMAN (P22303)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
ACHE

# Metabolic_Enzyme_8_Geneatlas_id:
ACHE

# Metabolic_Enzyme_8_hgnc_id:
HGNC:108

# Metabolic_Enzyme_8_PDB_ID:
1F8U

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_8_Gene_Sequence:
>1845 bp
ATGAGGCCCCCGCAGTGTCTGCTGCACACGCCTTCCCTGGCTTCCCCACTCCTTCTCCTC
CTCCTCTGGCTCCTGGGTGGAGGAGTGGGGGCTGAGGGCCGGGAGGATGCAGAGCTGCTG
GTGACGGTGCGTGGGGGCCGGCTGCGGGGCATTCGCCTGAAGACCCCCGGGGGCCCTGTC
TCTGCTTTCCTGGGCATCCCCTTTGCGGAGCCACCCATGGGACCCCGTCGCTTTCTGCCA
CCGGAGCCCAAGCAGCCTTGGTCAGGGGTGGTAGACGCTACAACCTTCCAGAGTGTCTGC
TACCAATATGTGGACACCCTATACCCAGGTTTTGAGGGCACCGAGATGTGGAACCCCAAC
CGTGAGCTGAGCGAGGACTGCCTGTACCTCAACGTGTGGACACCATACCCCCGGCCTACA
TCCCCCACCCCTGTCCTCGTCTGGATCTATGGGGGTGGCTTCTACAGTGGGGCCTCCTCC
TTGGACGTGTACGATGGCCGCTTCTTGGTACAGGCCGAGAGGACTGTGCTGGTGTCCATG
AACTACCGGGTGGGAGCCTTTGGCTTCCTGGCCCTGCCGGGGAGCCGAGAGGCCCCGGGC
AATGTGGGTCTCCTGGATCAGAGGCTGGCCCTGCAGTGGGTGCAGGAGAACGTGGCAGCC
TTCGGGGGTGACCCGACATCAGTGACGCTGTTTGGGGAGAGCGCGGGAGCCGCCTCGGTG
GGCATGCACCTGCTGTCCCCGCCCAGCCGGGGCCTGTTCCACAGGGCCGTGCTGCAGAGC
GGTGCCCCCAATGGACCCTGGGCCACGGTGGGCATGGGAGAGGCCCGTCGCAGGGCCACG
CAGCTGGCCCACCTTGTGGGCTGTCCTCCAGGCGGCACTGGTGGGAATGACACAGAGCTG
GTAGCCTGCCTTCGGACACGACCAGCGCAGGTCCTGGTGAACCACGAATGGCACGTGCTG
CCTCAAGAAAGCGTCTTCCGGTTCTCCTTCGTGCCTGTGGTAGATGGAGACTTCCTCAGT
GACACCCCAGAGGCCCTCATCAACGCGGGAGACTTCCACGGCCTGCAGGTGCTGGTGGGT
GTGGTGAAGGATGAGGGCTCGTATTTTCTGGTTTACGGGGCCCCAGGCTTCAGCAAAGAC
AACGAGTCTCTCATCAGCCGGGCCGAGTTCCTGGCCGGGGTGCGGGTCGGGGTTCCCCAG
GTAAGTGACCTGGCAGCCGAGGCTGTGGTCCTGCATTACACAGACTGGCTGCATCCCGAG
GACCCGGCACGCCTGAGGGAGGCCCTGAGCGATGTGGTGGGCGACCACAATGTCGTGTGC
CCCGTGGCCCAGCTGGCTGGGCGACTGGCTGCCCAGGGTGCCCGGGTCTACGCCTACGTC
TTTGAACACCGTGCTTCCACGCTCTCCTGGCCCCTGTGGATGGGGGTGCCCCACGGCTAC
GAGATCGAGTTCATCTTTGGGATCCCCCTGGACCCCTCTCGAAACTACACGGCAGAGGAG
AAAATCTTCGCCCAGCGACTGATGCGATACTGGGCCAACTTTGCCCGCACAGGGGATCCC
AATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAG
TACGTTAGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGC
GCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCCACCGACACGCTCGACGAGGCG
GAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAAC
CAGTTCGACCACTACAGCAAGCAGGATCGCTGCTCAGACCTGTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
M55040

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_8_Locus:
7q22

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
2263619; 12853948; 11239002; 8299725; 2714437; 1748670; 1517212; 9640563; 11053835; 8488842

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5824

# Metabolic_Enzyme_9_Name:
Acylphosphatase-2

# Metabolic_Enzyme_9_Synonyms:
Acylphosphate phosphohydrolase 2; Acylphosphatase, muscle type isozyme

# Metabolic_Enzyme_9_Gene_Name:
ACYP2

# Metabolic_Enzyme_9_Protein_Sequence:
>Acylphosphatase2
MSTAQSLKSVDYEVFGRVQGVCFRMYTEDEARKIGVVGWVKNTSKGTVTGQVQGPEDKVN
SMKSWLSKVGSPSSRIDRTNFSNEKTISKLEYSNFSIRY

# Metabolic_Enzyme_9_Number_of_Residues:
99

# Metabolic_Enzyme_9_Molecular_Weight:
11140

# Metabolic_Enzyme_9_Theoretical_pI:
10.01

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  acylphosphatase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_9_Specific_Function:
Its physiological role is not yet clear

# Metabolic_Enzyme_9_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00620  Pyruvate metabolism;
 map00632  Benzoate degradation via CoA ligation

# Metabolic_Enzyme_9_Reaction:
An acylphosphate + H2O = a carboxylate + phosphate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00708:Acylphosphatase

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 3.6.1.7

# Metabolic_Enzyme_9_GenBank_ID_Protein:
15341747

# Metabolic_Enzyme_9_SwissProt_ID:
ACYP2_HUMAN (P14621)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
ACYP2

# Metabolic_Enzyme_9_Geneatlas_id:
ACYP2

# Metabolic_Enzyme_9_hgnc_id:
HGNC:180

# Metabolic_Enzyme_9_PDB_ID:
1APS

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_9_Gene_Sequence:
>300 bp
ATGTCTACCGCCCAGTCACTCAAATCCGTGGACTACGAGGTGTTCGGAAGAGTGCAGGGT
GTTTGCTTCAGAATGTATACAGAAGATGAAGCTAGGAAAATAGGAGTGGTTGGCTGGGTG
AAGAATACCAGCAAAGGCACCGTGACAGGCCAAGTGCAGGGGCCAGAAGACAAAGTCAAT
TCCATGAAGTCCTGGCTGAGCAAGGTTGGAAGCCCTAGTTCTCGCATTGACCGCACAAAC
TTTTCTAATGAAAAAACCATCTCTAAGCTTGAATACTCTAATTTTAGTATTAGATACTAA


# Metabolic_Enzyme_9_GenBank_ID_Gene:
BC012290

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_9_Locus:
2p16.2

# Metabolic_Enzyme_9_SNPs:
rs13405053; rs11980; rs843762; rs1001296; rs843722; rs1399513; rs843716; rs698752; rs843748; rs843747; rs860057; rs843687; rs1484692; rs843730; rs843731; rs698755; rs843758; rs843752; rs843713; rs843671; rs843717; rs698750; rs843682; rs1358366; rs698756; rs843692; rs843765; rs843754; rs843657; rs843684; rs843714; rs843740; rs843767; rs843718; rs843755; rs843689; rs843656; rs1215145; rs843711; rs11894205; rs7574376; rs7586592; rs4671872; rs698751; rs977784; rs6751105; rs843749; rs10201710; rs11896279; rs843655; rs11680886; rs843696; rs11886559; rs843759; rs1727504; rs843763; rs6721970; rs10175251; rs7604464; rs1877908; rs10188489; rs843732; rs1682108; rs1421618; rs843653; rs1727506; rs10439478; rs843695; rs3915270; rs843678; rs11125528; rs13399590; rs6718204; rs7572559; rs1569086; rs843652; rs843651; rs6545388; rs11891079; rs1421619; rs843694; rs843751; rs3738855; rs7566894; rs10186140; rs11125529; rs7579722; rs10173565; rs843672; rs7574477; rs1727522; rs843726; rs843739; rs843675; rs843715; rs12615793; rs11884229; rs843673; rs843699; rs2357954; rs843677; rs843743; rs7562908; rs7594400; rs11125526; rs11884327; rs1872328; rs7573491; rs843764; rs11884435; rs1682109; rs1872329; rs1215152; rs1215146; rs843646; rs843737; rs6545387; rs7571660; rs12615749; rs6713088; rs843691; rs4553857; rs843741; rs1215147; rs843647; rs843679; rs10181332; rs7586074; rs843719; rs17045575; rs6732970; rs7559380; rs11678184; rs843649; rs7567556; rs843698; rs843686; rs860056; rs13390377; rs843756; rs10191400; rs843685; rs2695649; rs4671890; rs11892920; rs12614774; rs6717823; rs1877909; rs13407957; rs11899522; rs843735; rs12612860; rs843654; rs843710; rs13412967; rs7568345; rs1817557; rs10184018; rs7593450; rs2042143; rs6713993; rs843666; rs843725; rs1351881; rs4671891; rs6736179; rs7607826; rs12622470; rs10195704; rs1075265; rs843680; rs6744662; rs843733; rs1682102; rs1877907; rs7569743; rs17045654; rs11897209; rs964092; rs11890390; rs843724; rs2010461; rs11689599; rs11682807; rs1215154; rs1235407; rs2628197; rs11899551; rs7564849; rs10171521; rs1385273; rs7607209; rs843746; rs1877906; rs6545386; rs2112127; rs843723; rs843727; rs6706363; rs843659; rs2048749; rs13407991; rs843663; rs1872327; rs12465259; rs12615044; rs1215148; rs10496029; rs843664; rs843729; rs843650; rs13417267; rs13417493; rs843645; rs13423698; rs3850348; rs13411098; rs11889533; rs11690064; rs1727505; rs1913622; rs2357955; rs10207549; rs10206181; rs1727507; rs1727501; rs1215149; rs13407896; rs7592069; rs7593099; rs13424638; rs1385274; rs13410397; rs4671889; rs13420347; rs2112124; rs843760; rs9808326; rs843688; rs1215153; rs1727527; rs843728; rs1559039; rs12621747; rs6727644; rs843662; rs2287639; rs11125525; rs7567614; rs11902901; rs17045546; rs10184099; rs10171249; rs1682120; rs10206954; rs2287641; rs7567816; rs7593897; rs17045788; rs12621038; rs843697; rs10865281; rs843648; rs1215150; rs6721034; rs6545389; rs11885441; rs7584265; rs13426910; rs12619484; rs698753; rs1682121; rs13425449; rs10199041; rs12475488; rs843766; rs6743897; rs13400028; rs12616857; rs17045688; rs4588227; rs17045664; rs13384747; rs11895053; rs10180053; rs13406537; rs7584514; rs13396186; rs843709; rs6716768; rs17045711; rs11683930; rs6760158; rs13413363; rs12713254; rs17045536; rs7602930; rs12616744; rs13419158; rs12613693; rs10170925; rs17045773; rs17045645; rs4328670; rs843720; rs1682118; rs13407815; rs11125522; rs843661; rs11884867; rs10174714; rs6761289; rs2287640; rs12477919; rs3912428; rs13395449; rs17045765; rs13394772; rs1215157; rs1682113; rs1001297; rs11896604; rs843738; rs4302250; rs9309254; rs11689088; rs3738854; rs17045543; rs10193846; rs2090182; rs17045588; rs843753; rs13353360; rs1682119; rs17045680; rs13414565; rs11893929; rs13427743; rs10209379; rs843745; rs7592680; rs17045655; rs17045769; rs843690; rs6742463; rs2090183; rs17045792; rs7584399; rs17189820; rs1215156; rs1215155; rs11901576; rs843768; rs7595149; rs10172580; rs12618994; rs11886475; rs1569087; rs843674; rs7592819; rs10207316; rs7560496; rs17045803; rs17045585; rs7574651; rs843744; rs1682107; rs1035353; rs17045684; rs4133471; rs843676; rs7567646; rs13425290; rs843742; rs17045787; rs843658; rs13396318; rs17045690; rs1215151; rs17268381; rs11903579; rs17045704; rs10199945; rs10169755; rs843721; rs1099252; rs17045595; rs11893663; rs17268409; rs13421331; rs1986036; rs13413850; rs2449902; rs11902945; rs7579965; rs13417064; rs17045642; rs1215143; rs2080813; rs17045754; rs2112125; rs1580432; rs13001916; rs10207892; rs10194689; rs1843183; rs6757204; rs6747753; rs7559101; rs17189799; rs1215141; rs12623320; rs17045583; rs13423204; rs13416234; rs860058; rs10211315; rs17045755; rs17189659; rs13392879; rs843683; rs13393792; rs13386073; rs11125524; rs13407966; rs11125521; rs843761; rs13386287; rs17045696; rs11684075; rs7581283; rs17045660; rs7585336; rs17045569; rs13425337; rs13413198; rs4488701; rs9631060; rs843734; rs17045658; rs17189680; rs10181309; rs10182300; rs1099254; rs7589516; rs11895807; rs11889244; rs17045807; rs4671860; rs4671861; rs12617094; rs12620359; rs15136; rs843750; rs6726868; rs11338704; rs36006148; rs10670241; rs1727525; rs7605100; rs865816; rs865233; rs6723496; rs34214502; rs6723759; rs10205866; rs10195643; rs1099438; rs13412332; rs10192858; rs13432937; rs35814615; rs36119237; rs1843182; rs36030528; rs4619647; rs28376376; rs35623615; rs10649402; rs1236955; rs34121604; rs34918873; rs11125523; rs13001000; rs1727509; rs34162000; rs1514917; rs28679598; rs968260; rs7355768; rs11675579; rs866860; rs10195032; rs35059715; rs864579; rs34272855; rs34668689; rs6742557; rs7572767; rs7567531; rs3069007; rs34243306; rs1682133; rs13396362; rs34857873; rs7601410; rs13399915; rs698754; rs34122735; rs7589185; rs10210106; rs10695158; rs34136976; rs10180404; rs10616367; rs1727519; rs1601292; rs843757; rs1727524; rs11305602; rs13396310; rs11322993; rs35874994; rs34263169; rs4640424; rs35993761; rs35351322; rs9808489; rs35126790; rs13013288; rs844550; rs13028157; rs28445376; rs10673805; rs13420388; rs13403112; rs2358018; rs1682114; rs33926142; rs10185153; rs36071043; rs1727508; rs13393807; rs10680039; rs3069004; rs28559613; rs34894347; rs10207830; rs7605664; rs7603499; rs6728889; rs34432551; rs1237253; rs28558411; rs13395143; rs10571898; rs10193027; rs863621; rs3071186; rs13420248; rs1682094; rs13020565; rs13424470; rs36086569; rs13423617; rs13401548; rs6757372; rs11694461; rs34653284; rs10542497; rs5831291; rs35953014; rs1421620; rs17268276; rs10596948; rs1114007; rs13415762; rs6732104; rs11890605; rs28444585; rs11902367; rs13412139; rs36106602; rs13389240; rs34753426; rs1145513; rs13032125; rs34045950; rs1559040; rs864016; rs35174995; rs34429546; rs28489357; rs11310108; rs7355636; rs35951108; rs11903462; rs9807941; rs7592598; rs1682103; rs10172603; rs35068363; rs34379601; rs34195032; rs13432911; rs13423383; rs1905638; rs10607204; rs2930556; rs866859; rs6756174; rs843712; rs13390178; rs10172581; rs1682112; rs35990346; rs13383434; rs34110148; rs1682134; rs34344329; rs35424255; rs13008511; rs13004174; rs10184091; rs1099253; rs34202269; rs34632511; rs10172490; rs28376974; rs35932805; rs1238472; rs35426698; rs33976712; rs28492826; rs1682111; rs7607356; rs28599574; rs34469593; rs34644415; rs3916753; rs35962804; rs965109; rs2950569; rs3069029; rs10613395; rs35049240; rs34049474; rs13385032; rs7355635; rs10575339; rs35795352; rs10171734; rs34083989; rs35041614; rs5831290; rs2695648; rs7592484; rs35309943; rs11892194; rs1215138; rs34016483; rs35144373; rs7559709; rs1727500; rs843736; rs35334336; rs35812338; rs34258585; rs6741257; rs13397248; rs35347104; rs7558688; rs13392982; rs2161084; rs35908785; rs34803791; rs7606116; rs34731839; rs1215142; rs10531789; rs1682110; rs34440168; rs6732202; rs13415033; rs2018870; rs7355609; rs11886703; rs35216105; rs843660; rs1102808; rs34126566; rs952908; rs35433308; rs34014331; rs1075264; rs28544104; rs4671869; rs10611682; rs11432765; rs35145998; rs17189792; rs2695647; rs13412697; rs33952945; rs34494353; rs843665; rs34931097; rs35554061; rs2112126; rs843693; rs2463352; rs11295809; rs34846937; rs13400567; rs7570803; rs11459799; rs843681; rs35444317; rs34900505; rs34398621; rs10588789; rs13427038; rs2161085; rs35947065; rs7577156; rs13024714; rs34782040; rs34400204; rs34716415; rs35924164; rs2695646; rs13421534; rs5831292; rs1238469; rs7560189; rs6723912; rs4671916; rs7588179; rs34339832; rs13389469; rs13423343; rs34519856; rs2672671; rs28404178; rs12988218; rs866389; rs865234; rs11897951; rs10192952; rs35991339; rs7355466; rs3898888; rs11675345; rs34841607; rs35606644; rs35112914; rs10193885; rs2628196; rs34439903; rs1215144; rs34836192; rs35482637; rs3832035; rs13385842; rs34285007; rs13393594; rs10190498; rs34554365; rs6712502; rs4671917; rs34195465; rs34359444; rs34361625; rs6720696; rs10669711; rs34394331; rs35641543; rs1215139; rs34343315; rs10172798; rs35309455; rs13404903; rs28594245; rs28563086; rs35652253; rs3071218; rs1727526; rs34490974; rs10185189; rs35340218; rs13413118; rs35299326; rs35936212; rs35112731; rs34381809; rs34819287; rs7422723; rs7594550; rs13019605; rs1215140; rs13415920; rs34530011; rs7586755; rs35886675; rs9973583; rs698749; rs7558041; rs28481646; rs6746552; rs866858; rs35167194; rs35295105; rs11360655; rs35171056; rs34205094; rs7565453; rs11414020; rs11445871; rs34810157; rs10534567; rs10165485; rs10176342; rs10176406; rs11674614; rs11888384; rs13005618; rs13034077; rs13390991; rs13401799; rs13411458; rs13424808; rs13428453; rs17039541; rs17039547; rs17045513; rs17189743; rs2287642; rs2287643; rs2287644; rs2287645; rs34338213; rs34433964; rs34567788; rs6715177; rs6724542; rs6735998; rs6740641; rs7562055; rs843638; rs843639; rs843700; rs843701; rs843702; rs843704; rs843705; rs843706; rs843707; rs863622; rs865817; rs866390; rs866861; rs918356; rs918357; rs929733; rs929734

# Metabolic_Enzyme_9_General_References:
6100723; 7487897

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5825

# Metabolic_Enzyme_10_Name:
Acylphosphatase-1

# Metabolic_Enzyme_10_Synonyms:
Acylphosphate phosphohydrolase 1; Acylphosphatase, organ-common type isozyme; Acylphosphatase, erythrocyte isozyme

# Metabolic_Enzyme_10_Gene_Name:
ACYP1

# Metabolic_Enzyme_10_Protein_Sequence:
>Acylphosphatase1
MAEGNTLISVDYEIFGKVQGVFFRKHTQAEGKKLGLVGWVQNTDRGTVQGQLQGPISKVR
HMQEWLETRGSPKSHIDKANFNNEKVILKLDYSDFQIVK

# Metabolic_Enzyme_10_Number_of_Residues:
99

# Metabolic_Enzyme_10_Molecular_Weight:
11261

# Metabolic_Enzyme_10_Theoretical_pI:
9.94

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  acylphosphatase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_10_Specific_Function:
Its physiological role is not yet clear

# Metabolic_Enzyme_10_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00620  Pyruvate metabolism;
 map00632  Benzoate degradation via CoA ligation

# Metabolic_Enzyme_10_Reaction:
An acylphosphate + H2O = a carboxylate + phosphate

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00708:Acylphosphatase

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 3.6.1.7

# Metabolic_Enzyme_10_GenBank_ID_Protein:
1834464

# Metabolic_Enzyme_10_SwissProt_ID:
ACYP1_HUMAN (P07311)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
ACYP1

# Metabolic_Enzyme_10_Geneatlas_id:
ACYP1

# Metabolic_Enzyme_10_hgnc_id:
HGNC:179

# Metabolic_Enzyme_10_PDB_ID:
2ACY

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_10_Gene_Sequence:
>300 bp
ATGGCAGAGGGAAACACCCTGATATCAGTGGATTATGAAATTTTTGGGAAGGTGCAAGGG
GTGTTTTTCCGTAAGCATACTCAGGCTGAGGGTAAAAAGCTGGGATTGGTAGGCTGGGTC
CAGAACACTGACCGGGGCACAGTGCAAGGACAATTGCAAGGTCCAATCTCCAAGGTGCGT
CATATGCAGGAATGGCTTGAAACAAGAGGAAGTCCTAAATCACACATCGACAAAGCAAAC
TTCAACAATGAAAAAGTCATCTTGAAGTTGGATTACTCAGACTTCCAAATTGTAAAATAA


# Metabolic_Enzyme_10_GenBank_ID_Gene:
X84194

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_10_Locus:
14q24.3

# Metabolic_Enzyme_10_SNPs:
rs175505; rs175508; rs175512; rs10142770; rs10149551; rs10149362; rs10143132; rs10129657; rs10873275; rs175504; rs10438026; rs4312248; rs35265522; rs33946767; rs34696420; rs175509; rs34945501; rs35643666; rs4026176; rs35401825; rs175507; rs11623238; rs10549398; rs175513; rs175510; rs34805683; rs175506; rs175511; rs33920224; rs11845186; rs10136948; rs11546525; rs11556091; rs12050143; rs12432005; rs17102999; rs175080; rs175081; rs175082; rs175083; rs175084; rs175085; rs175498; rs175499; rs175500; rs175501; rs175502; rs17782839; rs2273162; rs28756977; rs28756981; rs28756986; rs28756987; rs28756988; rs28756991; rs28937870; rs28937871; rs3180779; rs34012003; rs34248766; rs3742778; rs4903278; rs7303

# Metabolic_Enzyme_10_General_References:
12508121; 3026468; 7796909

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5253

# Metabolic_Enzyme_11_Name:
Acyl-coenzyme A thioesterase 12

# Metabolic_Enzyme_11_Synonyms:
Acyl-CoA thioesterase 12; Acyl-CoA thioester hydrolase 12; Cytoplasmic acetyl-CoA hydrolase 1; CACH-1; hCACH-1; START domain-containing protein 12; StARD12

# Metabolic_Enzyme_11_Gene_Name:
ACOT12

# Metabolic_Enzyme_11_Protein_Sequence:
>Acylcoenzyme A thioesterase 12
MERPAPGEVVMSQAIQPAHATARGELSAGQLLKWIDTTACLAAEKHAGVSCVTASVDDIQ
FEETARVGQVITIKAKVTRAFSTSMEISIKVMVQDMLTGIEKLVSVAFSTFVAKPVGKEK
IHLKPVTLLTEQDHVEHNLAAERRKVRLQHEDTFNNLMKESSKFDDLIFDEEEGAVSTRG
TSVQSIELVLPPHANHHGNTFGGQIMAWMETVATISASRLCWAHPFLKSVDMFKFRGPST
VGDRLVFTAIVNNTFQTCVEVGVRVEAFDCQEWAEGRGRHINSAFLIYNAADDKENLITF
PRIQPISKDDFRRYRGAIARKRIRLGRKYVISHKEEVPLCIHWDISKQASLSDSNVEALK
KLAAKRGWEVTSTVEKIKIYTLEEHDVLSVWVEKHVGSPAHLAYRLLSDFTKRPLWDPHF
VSCEVIDWVSEDDQLYHITCPILNDDKPKDLVVLVSRRKPLKDGNTYTVAVKSVILPSVP
PSPQYIRSEIICAGFLIHAIDSNSCIVSYFNHMSASILPYFAGNLGGWSKSIEETAASCI
QFLENPPDDGFVSTF

# Metabolic_Enzyme_11_Number_of_Residues:
555

# Metabolic_Enzyme_11_Molecular_Weight:
62035

# Metabolic_Enzyme_11_Theoretical_pI:
6.76

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
Hydrolyzes acetyl-CoA to acetate and CoA

# Metabolic_Enzyme_11_Pathway:
map00620  Pyruvate metabolism

# Metabolic_Enzyme_11_Reaction:
acetyl-CoA + H2O = CoA + acetate

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF03061:4HBT;
PF01852:START

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 3.1.2.1

# Metabolic_Enzyme_11_GenBank_ID_Protein:
18307694

# Metabolic_Enzyme_11_SwissProt_ID:
ACO12_HUMAN (Q8WYK0)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
ACOT12

# Metabolic_Enzyme_11_Geneatlas_id:
ACOT12

# Metabolic_Enzyme_11_hgnc_id:
HGNC:24436

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_11_Gene_Sequence:
>1668 bp
ATGGAGCGGCCGGCGCCCGGCGAGGTGGTCATGAGCCAAGCCATCCAGCCGGCGCACGCC
ACTGCGCGCGGCGAGCTGAGCGCGGGGCAGCTGCTCAAGTGGATCGACACCACCGCCTGC
CTGGCGGCTGAGAAACATGCTGGAGTTTCCTGCGTTACAGCCTCAGTGGATGACATACAG
TTTGAGGAGACAGCTAGAGTTGGACAAGTTATAACCATCAAAGCAAAAGTTACTAGAGCA
TTCAGCACAAGCATGGAGATCAGTATCAAGGTCATGGTACAGGATATGCTCACTGGCATT
GAGAAGCTTGTTAGTGTGGCTTTCTCCACATTTGTAGCCAAACCAGTTGGAAAAGAAAAG
ATTCATTTAAAACCAGTCACACTTCTAACTGAACAAGATCATGTGGAACATAATCTGGCT
GCTGAGAGAAGGAAAGTTCGATTACAACATGAAGATACCTTTAACAATTTAATGAAGGAA
AGTAGCAAATTTGATGATCTCATTTTTGATGAAGAGGAAGGAGCGGTTTCCACAAGGGGC
ACCTCCGTTCAGAGCATTGAACTGGTCCTCCCACCCCATGCAAACCATCACGGAAATACA
TTTGGTGGCCAGATTATGGCGTGGATGGAGACAGTGGCTACTATTTCTGCAAGCCGCCTG
TGTTGGGCTCATCCCTTTCTGAAGTCCGTAGATATGTTTAAGTTCCGGGGACCATCTACA
GTTGGAGATCGTCTTGTCTTCACTGCCATTGTCAACAATACATTTCAGACCTGTGTTGAA
GTTGGAGTTCGCGTGGAGGCCTTTGACTGTCAGGAATGGGCCGAGGGCCGAGGGCGTCAC
ATCAACAGTGCTTTTCTCATTTACAATGCTGCTGATGATAAGGAAAATCTCATCACGTTT
CCCAGAATCCAACCCATTTCAAAGGATGATTTCAGACGCTATCGGGGAGCTATTGCACGC
AAGCGAATTCGCCTAGGCAGAAAATATGTTATTTCCCACAAAGAAGAGGTTCCACTTTGC
ATACACTGGGATATCAGCAAGCAGGCATCCCTGAGTGACAGCAATGTGGAGGCCCTCAAA
AAACTGGCAGCCAAAAGGGGTTGGGAGGTTACCAGCACTGTGGAAAAGATAAAAATATAT
ACTCTGGAAGAGCATGATGTTTTATCTGTTTGGGTTGAAAAGCACGTGGGAAGTCCAGCA
CATTTGGCTTATCGTCTCTTGTCTGACTTTACAAAGCGACCTTTGTGGGACCCCCATTTT
GTGTCCTGTGAAGTCATAGACTGGGTGAGTGAAGATGATCAGCTGTATCACATCACCTGT
CCTATACTGAATGATGACAAACCCAAAGACTTGGTAGTACTCGTATCACGAAGAAAACCC
CTCAAAGATGGTAACACTTACACAGTGGCAGTGAAGTCGGTCATTTTGCCATCGGTCCCC
CCGTCTCCACAGTACATCAGAAGTGAAATCATATGTGCCGGATTTCTCATCCATGCTATT
GACAGCAATTCATGCATCGTATCTTACTTTAACCATATGTCTGCTAGCATCCTTCCTTAC
TTTGCTGGAAATCTTGGTGGCTGGTCAAAATCCATTGAAGAAACAGCAGCCTCTTGTATA
CAGTTCTTAGAGAATCCTCCTGATGATGGGTTTGTAAGCACATTTTAA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
AB078619

# Metabolic_Enzyme_11_Chromosome_Location:
Not Available

# Metabolic_Enzyme_11_Locus:
Not Available

# Metabolic_Enzyme_11_SNPs:
Not Available

# Metabolic_Enzyme_11_General_References:
Not Available

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5271

# Metabolic_Enzyme_12_Name:
Acetyl-coenzyme A synthetase 2-like, mitochondrial precursor

# Metabolic_Enzyme_12_Synonyms:
Acetate--CoA ligase 2; Acetyl-CoA synthetase 2; Acyl- CoA synthetase short-chain family member 1

# Metabolic_Enzyme_12_Gene_Name:
ACSS1

# Metabolic_Enzyme_12_Protein_Sequence:
>Acetylcoenzyme A synthetase 2like, mitochondrial precursor
MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPGSYPA
LSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVR
KSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVA
AMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVK
HCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGM
PKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLF
ESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPI
NCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVL
MDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEG
GYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKD
SAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELG
DTTTLEDPSIIAEILSVYQKCKDKQAAAK

# Metabolic_Enzyme_12_Number_of_Residues:
689

# Metabolic_Enzyme_12_Molecular_Weight:
74857

# Metabolic_Enzyme_12_Theoretical_pI:
7.11

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  AMP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-sulfur bonds
Function:  CoA-ligase activity
Function:  acetate-CoA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_12_Specific_Function:
Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2)

# Metabolic_Enzyme_12_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_12_Reaction:
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_12_Signals:
1-22

# Metabolic_Enzyme_12_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 6.2.1.1

# Metabolic_Enzyme_12_GenBank_ID_Protein:
56203089

# Metabolic_Enzyme_12_SwissProt_ID:
ACS2L_HUMAN (Q9NUB1)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
ACSS1

# Metabolic_Enzyme_12_Geneatlas_id:
ACSS1

# Metabolic_Enzyme_12_hgnc_id:
HGNC:16091

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_12_Gene_Sequence:
>1439 bp
CCAAGTGCAAGGTGGTTATCACCTTCAACCAAGGACTCCGGGGTGGGCGCGTGGTGGAGC
TGAAGAAAATAGTGGATGAGGCTGTGAAGCACTGCCCCACCGTGCAGCATGTCCTGGTGG
CTCACAGGACAGACAACAAGGTCCACATGGGGGATCTGGACGTCCCGCTGGAGCAGGAAA
TGGCCAAGGAGGACCCTGTTTGCGCCCCAGAGAGCATGGGCAGTGAGGACATGCTCTTCA
TGCTGTACACCTCAGGGAGCACCGGAATGCCCAAGGGCATCGTCCATACCCAGGCAGGCT
ACCTGCTCTATGCCGCCCTGACTCACAAGCTTGTGTTTGACCACCAGCCAGGTGACATCT
TTGGCTGTGTGGCCGACATCGGTTGGATTACAGGACACAGCTACGTGGTGTATGGGCCTC
TCTGCAATGGTGCCACCAGCGTCCTTTTTGAGAGCACCCCAGTTTATCCCAATGCTGGTC
GGTACTGGGAGACAGTAGAGAGGTTGAAGATCAATCAGTTCTATGGCGCCCCAACGGCTG
TCCGGCTGTTGCTGAAATACGGTGATGCCTGGGTGAAGAAGTATGATCGCTCCTCCCTGC
GGACCCTGGGGTCAGTGGGAGAGCCCATCAACTGTGAGGCCTGGGAGTGGCTTCACAGGG
TGGTGGGGGACAGCAGGTGCACGCTGGTGGACACCTGGTGGCAGACAGAAACAGGTGGCA
TCTGCATCGCACCACGGCCCTCGGAAGAAGGGGCGGAAATCCTCCCTGCCATGGCGATGA
GGCCCTTCTTTGGCATCGTCCCCGTCCTCATGGATGAGAAGGGCAGCGTCGTGGAGGGCA
GCAACGTCTCCGGGGCCCTGTGCATCTCCCAGGCCTGGCCGGGCATGGCCAGGACCATCT
ATGGCGACCACCAGCGATTTGTGGACGCCTACTTCAAGGCCTACCCAGGCTATTACTTCA
CTGGAGACGGGGCTTACCGAACTGAGGGCGGCTATTACCAGATCACAGGGCGGATGGATG
ATGTCATCAACATCAGTGGCCACCGGCTGGGGACCGCAGAGATTGAGGACGCCATCGCCG
ACCACCCTGCAGTACCAGAAAGTGCTGTCATTGGCTACCCCCACGACATCAAAGGAGAAG
CTGCCTTTGCCTTCATTGTGGTGAAAGATAGTGCGGGTGACTCAGATGTGGTGGTGCAGG
AGCTCAAGTCCATGGTGGCCACCAAGATCGCCAAATATGCTGTGCCTGATGAGATCCTGG
TGGTGAAACGTCTTCCAAAAACCAGGTCTGGGAAGGTCATGCGGCGGCTCCTGAGGAAGA
TCATCACTAGTGAGGCCCAGGAGCTGGGAGACACTACCACCTTGGAGGACCCCAGCATCA
TCGCAGAGATCCTGAGTGTCTACCAGAAGTGCAAGGACAAGCAGGCTGCTGCTAAGTGA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
AL035661

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_12_Locus:
20p11.23-p11.21

# Metabolic_Enzyme_12_SNPs:
rs6050249; rs6115003; rs6050259; rs6115001; rs3746331; rs6114999; rs6132784; rs6083718; rs2294980; rs3646; rs3746332; rs8118803; rs6050261; rs6050266; rs7270236; rs6132785; rs11697253; rs11699487; rs6050255; rs8114108; rs910526; rs1007881; rs6138466; rs6115000; rs6083728; rs11908104; rs3746330; rs6050281; rs6138473; rs6050267; rs8124799; rs6115002; rs6115010; rs910527; rs4815363; rs6132792; rs11908037; rs6083725; rs761720; rs6050252; rs7263112; rs6132789; rs6115015; rs2144371; rs2179732; rs4815364; rs6106989; rs8121327; rs4815361; rs6050268; rs11698964; rs6083726; rs6037010; rs7271250; rs6076312; rs1015278; rs6138478; rs1985485; rs6037007; rs6515575; rs11699824; rs11907003; rs6050263; rs6106986; rs12624595; rs6138475; rs6050262; rs6083729; rs6083727; rs7273310; rs6050270; rs11907817; rs6138470; rs8119255; rs12481389; rs7268879; rs6138474; rs7273518; rs6050257; rs6115011; rs6083730; rs4813543; rs4392331; rs6115009; rs6115008; rs7265897; rs13039383; rs1960190; rs11698942; rs6115013; rs6050264; rs11907559; rs7262168; rs7266133; rs6106985; rs6050253; rs12480685; rs6037013; rs1555157; rs1555158; rs7273872; rs6138465; rs6138464; rs7268196; rs6114995; rs3928737; rs6050244; rs7273998; rs6037006; rs6114996; rs6114997; rs6050290; rs1973921; rs9967918; rs6083719; rs41308619; rs6050250; rs41315096; rs34418920; rs7265950; rs6050247; rs8118553; rs6050245; rs6050246; rs6050248; rs11349463; rs6114998; rs3746333; rs11556305; rs6138480; rs6037009; rs2024740; rs6083720; rs6050282; rs34106051; rs34040475; rs6138467; rs7265967; rs35754748; rs6106987; rs7347286; rs7268641; rs35918514; rs5841047; rs6050285; rs11908357; rs6132786; rs10667081; rs6050273; rs6050288; rs35440489; rs11475510; rs11087496; rs6050283; rs2235848; rs6083721; rs41315094; rs5841046; rs35370044; rs6132788; rs6050258; rs35022349; rs6132787; rs36083645; rs6037011; rs34821066; rs6138479; rs33974103; rs34478164; rs6138481; rs6083731; rs6115018; rs7363000; rs6138472; rs6050286; rs35714586; rs6115014; rs6083723; rs6050265; rs8123929; rs35559944; rs34768826; rs6050275; rs35187537; rs6132793; rs34248454; rs4813544; rs6050269; rs6115012; rs33947143; rs6083724; rs34068044; rs34114131; rs34202442; rs6050272; rs35419604; rs11474894; rs34478614; rs7272596; rs34772607; rs11696684; rs6132791; rs3086647; rs6106990; rs6138471; rs11469635; rs7265721; rs10701711; rs11699715; rs6050271; rs35841792; rs6050251; rs8114568; rs34766073; rs34911154; rs6050284; rs34012555; rs35888097; rs6132790; rs11472149; rs8123923; rs34740612; rs36081306; rs7270177; rs8182893; rs6037008; rs11473680; rs6050287; rs11480696; rs6138476; rs6050274; rs34340531; rs4815365; rs8184324; rs33955639; rs5841045; rs11482316; rs6050289; rs35994199; rs7271571; rs1005409; rs11905625; rs11905675; rs2207631; rs2387573; rs2387577; rs4239751; rs6050243; rs6050291; rs6083712; rs6083713; rs6083714; rs6114987; rs6114991; rs6138461; rs6138462; rs7274899

# Metabolic_Enzyme_12_General_References:
11780052; 11347906; 12168954

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5826

# Metabolic_Enzyme_13_Name:
Aminoacylase-1

# Metabolic_Enzyme_13_Synonyms:
N-acyl-L-amino-acid amidohydrolase; ACY-1

# Metabolic_Enzyme_13_Gene_Name:
ACY1

# Metabolic_Enzyme_13_Protein_Sequence:
>Aminoacylase1
MTSKGPEEEHPSVTLFRQYLRIRTVQPKPDYGAAVAFFEETARQLGLGCQKVEVAPGYVV
TVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQ
YLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANP
TDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSN
PHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEG
VTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPAL
GFSPMNRTPVLLHDHDERLHEAVFLRGVDIYTRLLPALASVPALPSDS

# Metabolic_Enzyme_13_Number_of_Residues:
408

# Metabolic_Enzyme_13_Molecular_Weight:
45885

# Metabolic_Enzyme_13_Theoretical_pI:
6.12

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  protein dimerization activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Function:  aminoacylase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  metallopeptidase activity
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_13_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_13_Specific_Function:
Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate)

# Metabolic_Enzyme_13_Pathway:
map00220  Urea cycle and metabolism of amino groups

# Metabolic_Enzyme_13_Reaction:
An N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF07687:M20_dimer;
PF01546:Peptidase_M20

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
None

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 3.5.1.14

# Metabolic_Enzyme_13_GenBank_ID_Protein:
178071

# Metabolic_Enzyme_13_SwissProt_ID:
ACY1_HUMAN (Q03154)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
ACY1

# Metabolic_Enzyme_13_Geneatlas_id:
ACY1

# Metabolic_Enzyme_13_hgnc_id:
HGNC:177

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_13_Gene_Sequence:
>1227 bp
ATGACCAGCAAGGGTCCCGAGGAGGAGCACCCATCGGTGACGCTCTTCCGCCAGTACCTG
CGTATCCGCACTGTCCAGCCCAAGCCTGACTATGGAGCTGCTGTGGCTTTCTTTGAGGAG
ACAGCCCGCCAGCTGGGCCTGGGCTGTCAGAAAGTAGAGGTGGCACCTGGCTATGTGGTG
ACCGTGTTGACCTGGCCAGGCACCAACCCTACACTCTCCTCCATCTTGCTCAACTCCCAC
ACGGATGTGGTGCCTGTCTTCAAGGAACATTGGAGTCACGACCCCTTTGAGGCCTTCAAG
GATTCTGAGGGCTACATCTATGCCAGGGGTGCCCAGGACATGAAGTGCGTCAGCATCCAG
TACCTGGAAGCTGTGAGGAGGCTGAAGGTGGAGGGCCACCGGTTCCCCAGAACCATCCAC
ATGACCTTTGTGCCTGATGAGGAGGTTGGGGGTCACCAAGGCATGGAGCTGTTCGTGCAG
CGGCCTGAGTTCCACGCCCTGAGGGCAGGCTTTGCCCTGGATGAGGGCATAGCCAATCCC
ACTGATGCCTTCACTGTCTTTTATAGTGAGCGGAGTCCCTGGTGGGTGCGGGTTACCAGC
ACTGGGAGGCCAGGCCATGCCTCACGCTTCATGGAGGACACAGCAGCAGAGAAGCTGCAC
AAGGTTGTAAACTCCATCCTGGCATTCCGGGAGAAGGAATGGCAGAGGCTGCAGTCAAAC
CCCCACCTGAAAGAGGGGTCCGTGACCTCCGTGAACCTGACTAAGCTAGAGGGTGGCGTG
GCCTATAACGTGATACCTGCCACCATGAGCGCCAGCTTTGACTTCCGTGTGGCACCGGAT
GTGGACTTCAAGGCTTTTGAGGAGCAGCTGCAGAGCTGGTGCCAGGCAGCTGGCGAGGGG
GTCACCCTAGAGTTTGCTCAGAAGTGGATGCACCCCCAAGTGACACCTACTGATGACTCA
AACCCTTGGTGGGCAGCTTTTAGCCGGGTCTGCAAGGATATGAACCTCACTCTGGAGCCT
GAGATCATGCCTGCTGCCACTGACAACCGCTATATCCGCGCGGTGGGGGTCCCAGCTCTA
GGCTTCTCACCCATGAACCGCACACCTGTGCTGCTGCACGACCACGATGAACGGCTGCAT
GAGGCTGTGTTCCTCCGTGGGGTGGACATATATACACGCCTGCTGCCTGCCCTTGCCAGT
GTGCCTGCCCTGCCCAGTGACAGCTGA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
L07548

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_13_Locus:
3p21.1

# Metabolic_Enzyme_13_SNPs:
rs887540; rs34017492; rs323894; rs323895; rs323892; rs323893; rs82854; rs887541; rs2229152; rs6804746; rs11544304; rs11457478; rs11442467; rs34491128; rs3211518; rs178917; rs41292352; rs35075916; rs34879976; rs11924757; rs35346203; rs34294622; rs34300686; rs34903202; rs323890; rs3178066; rs35275952; rs2015691; rs3178064; rs323858; rs323862; rs323863; rs323891; rs323896; rs323897; rs34118567; rs34149506; rs34991570; rs380788; rs3821828; rs404527; rs411209; rs433823; rs6446153; rs6768522; rs740923; rs7432986

# Metabolic_Enzyme_13_General_References:
8357837; 8394326

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5827

# Metabolic_Enzyme_14_Name:
Aspartoacylase

# Metabolic_Enzyme_14_Synonyms:
Aminoacylase-2; ACY-2

# Metabolic_Enzyme_14_Gene_Name:
ASPA

# Metabolic_Enzyme_14_Protein_Sequence:
>Aspartoacylase
MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK
CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS
NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG
PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA
AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK
LTLNAKSIRCCLH

# Metabolic_Enzyme_14_Number_of_Residues:
313

# Metabolic_Enzyme_14_Molecular_Weight:
35736

# Metabolic_Enzyme_14_Theoretical_pI:
6.51

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids

# Metabolic_Enzyme_14_Pathway:
map00252  Alanine and aspartate metabolism;
 map00340  Histidine metabolism

# Metabolic_Enzyme_14_Reaction:
N-acyl-L-aspartate + H2O = a carboxylate + L-aspartate

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF04952:AstE_AspA

# Metabolic_Enzyme_14_Signals:
None

# Metabolic_Enzyme_14_Transmembrane_Regions:
None

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 3.5.1.15

# Metabolic_Enzyme_14_GenBank_ID_Protein:
455834

# Metabolic_Enzyme_14_SwissProt_ID:
ACY2_HUMAN (P45381)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
ASPA

# Metabolic_Enzyme_14_Geneatlas_id:
ASPA

# Metabolic_Enzyme_14_hgnc_id:
HGNC:756

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_14_Gene_Sequence:
>942 bp
ATGACTTCTTGTCACATTGCTGAAGAACATATACAAAAGGTTGCTATCTTTGGAGGAACC
CATGGGAATGAGCTAACCGGAGTATTTCTGGTTAAGCATTGGCTAGAGAATGGCGCTGAG
ATTCAGAGAACAGGGCTGGAGGTAAAACCATTTATTACTAACCCCAGAGCAGTGAAGAAG
TGTACCAGATATATTGACTGTGACCTGAATCGCATTTTTGACCTTGAAAATCTTGGCAAA
AAAATGTCAGAAGATTTGCCATATGAAGTGAGAAGGGCTCAAGAAATAAATCATTTATTT
GGTCCAAAAGACAGTGAAGATTCCTATGACATTATTTTTGACCTTCACAACACCACCTCT
AACATGGGGTGCACTCTTATTCTTGAGGATTCCAGGAATAACTTTTTAATTCAGATGTTT
CATTACATTAAGACTTCTCTGGCTCCACTACCCTGCTACGTTTATCTGATTGAGCATCCT
TCCCTCAAATATGCGACCACTCGTTCCATAGCCAAGTATCCTGTGGGTATAGAAGTTGGT
CCTCAGCCTCAAGGGGTTCTGAGAGCTGATATCTTGGATCAAATGAGAAAAATGATTAAA
CATGCTCTTGATTTTATACATCATTTCAATGAAGGAAAAGAATTTCCTCCCTGCGCCATT
GAGGTCTATAAAATTATAGAGAAAGTTGATTACCCCCGGGATGAAAATGGAGAAATTGCT
GCTATCATCCATCCTAATCTGCAGGATCAAGACTGGAAACCACTGCATCCTGGGGATCCC
ATGTTTTTAACTCTTGATGGGAAGACGATCCCACTGGGCGGAGACTGTACCGTGTACCCC
GTGTTTGTGAATGAGGCCGCATATTACGAAAAGAAAGAAGCTTTTGCAAAGACAACTAAA
CTAACGCTCAATGCAAAAAGTATTCGCTGCTGTTTACATTAG

# Metabolic_Enzyme_14_GenBank_ID_Gene:
S67156

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_14_Locus:
17pter-p13

# Metabolic_Enzyme_14_SNPs:
rs12948217; rs28940279; rs9896885; rs1873061; rs2131517; rs1488688; rs1493282; rs9902120; rs2035939; rs2029352; rs2029350; rs2035938; rs923376; rs9889588; rs9902229; rs4790496; rs6502727; rs923375; rs11652568; rs9916804; rs11869485; rs2318036; rs9904040; rs9910285; rs4790495; rs8068225; rs3786009; rs7215891; rs2029351; rs12948872; rs11651636; rs9904168; rs9901015; rs9906620; rs8065488; rs17762979; rs2279567; rs11868193; rs6502726; rs8071141; rs6502728; rs3744670; rs11656291; rs17222495; rs8068239; rs16953070; rs3786010; rs12051797; rs8066886; rs17222551; rs8075119; rs9899946; rs12601330; rs1964623; rs12941620; rs12946424; rs9889604; rs16953074; rs1971292; rs35002210; rs17175228; rs7220559; rs9941396; rs11078450; rs3829957; rs11078451; rs3814886; rs28940574; rs17850703; rs1552830; rs35730123; rs10524882; rs12937166; rs3837856; rs5818896; rs34680506; rs36034906; rs9894622; rs36051310; rs3037735; rs2318038; rs34109510; rs12602137; rs11380439; rs35614631; rs12943481; rs8072059; rs12952852; rs35178659; rs2318040; rs34015272; rs2200728; rs2318037; rs8066628; rs8081562; rs34744839; rs12951114; rs35225782; rs12936895; rs35095578; rs35629100; rs34365618; rs36033666; rs34002091; rs2318039; rs34054576; rs3215041; rs12603718; rs34275920; rs12945398; rs5818897; rs36225687; rs6145956; rs8069497; rs3039623; rs10521121; rs11649929; rs11653068; rs11656519; rs11657794; rs12450574; rs12602543; rs12940665; rs12946429; rs16953091; rs17822693; rs34838258; rs3786011; rs4790142; rs4790500; rs7209613; rs7211452; rs7216314; rs7217800; rs7220982; rs7221929; rs7223710; rs8065143; rs8065249; rs8075699; rs8079320; rs9890041

# Metabolic_Enzyme_14_General_References:
8252036; 12706335; 8023850; 7668285; 7599639; 9452117; 10564886; 10909858; 12638939; 12205125

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5810

# Metabolic_Enzyme_15_Name:
Aldehyde dehydrogenase 3B2

# Metabolic_Enzyme_15_Synonyms:
Aldehyde dehydrogenase 8

# Metabolic_Enzyme_15_Gene_Name:
ALDH3B2

# Metabolic_Enzyme_15_Protein_Sequence:
>Aldehyde dehydrogenase 3B2
MKDEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGNCVVLKPSE
ISQGTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAAT
KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLL
PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVL
VDVQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERT
SSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEI
RYPPYTDWNQQLLRWGMGSQSCTLL

# Metabolic_Enzyme_15_Number_of_Residues:
385

# Metabolic_Enzyme_15_Molecular_Weight:
42670

# Metabolic_Enzyme_15_Theoretical_pI:
5.97

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_15_Specific_Function:
An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

# Metabolic_Enzyme_15_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_15_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_15_Signals:
None

# Metabolic_Enzyme_15_Transmembrane_Regions:
None

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_15_GenBank_ID_Protein:
1051281

# Metabolic_Enzyme_15_SwissProt_ID:
AL3B2_HUMAN (P48448)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
ALDH3B2

# Metabolic_Enzyme_15_Geneatlas_id:
ALDH3B2

# Metabolic_Enzyme_15_hgnc_id:
HGNC:411

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Not Available

# Metabolic_Enzyme_15_Gene_Sequence:
>1158 bp
ATGAAGGATGAACCACGGTCCACGAACCTGTTCATGAAGCTGGACTCGGTCTTCATCTGG
AAGGAACCCTTTGGCCTGGTCCTCATCATCGCACCCTGGAACTACCCATTGAACCTGACC
CTGGTGCTCCTGGTGGGCACCCTCCCCGCAGGGAATTGCGTGGTGCTGAAGCCGTCAGAA
ATCAGCCAGGGCACAGAGAAGGTCCTGGCTGAGGTGCTGCCCCAGTACCTGGACCAGAGC
TGCTTTGCCGTGGTGCTGGGCGGACCCCAGGAGACAGGGCAGCTGCTAGAGCACAAGTTG
GACTACATCTTCTTCACAGGGAGCCCTCGTGTGGGCAAGATTGTCATGACTGCTGCCACC
AAGCACCTGACGCCTGTCACCCTGGAGCTGGGGGGCAAGAACCCCTGCTACGTGGACGAC
AACTGCGACCCCCAGACCGTGGCCAACCGCGTGGCCTGGTTCTGCTACTTCAATGCCGGC
CAGACCTGCGTGGCCCCTGACTACGTCCTGTGCAGCCCCGAGATGCAGGAGAGGCTGCTG
CCCGCCCTGCAGAGCACCATCACCCGTTTCTATGGCGACGACCCCCAGAGCTCCCCAAAC
CTGGGCCGCATCATCAACCAGAAACAGTTCCAGCGGCTGCGGGCATTGCTGGGCTGCGGC
CGCGTGGCCATTGGGGGCCAGAGCAACGAGAGCGATCGCTACATCGCCCCCACGGTGCTG
GTGGACGTGCAGGAGACGGAGCCTGTGATGCAGGAGGAGATCTTCGGGCCCATCCTGCCC
ATCGTGAACGTGCAGAGCGTGGACGAGGCCATCAAGTTCATCAACCGGCAGGAGAAGCCC
CTGGCCCTGTACGCCTTCTCCAACAGCAGACAGGTTGTGAACCAGATGCTGGAGCGGACC
AGCAGCGGCAGCTTTGGAGGCAATGAGGGCTTCACCTACATATCTCTGCTGTCCGTGCCA
TTCGGGGGAGTCGGCCACAGTGGGATGGGCCGGTACCACGGCAAGTTCACCTTCGACACC
TTCTCCCACCACCGCACCTGCCTGCTCGCCCCCTCCGGCCTGGAGAAATTAAAGGAGATC
CGCTACCCACCCTATACCGACTGGAACCAGCAGCTGTTACGCTGGGGCATGGGCTCCCAG
AGCTGCACCCTCCTGTGA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
U37519

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_15_Locus:
11q13

# Metabolic_Enzyme_15_SNPs:
rs3741178; rs1551888; rs4646826; rs6591270; rs1551886; rs3741172; rs2279123; rs2279124; rs17510687; rs4313593; rs3127; rs1551885; rs3808972; rs2279125; rs1903829; rs866907; rs7947978; rs11823098; rs7114210; rs2514061; rs2251277; rs6591274; rs6591273; rs4646823; rs3825021; rs28372760; rs2279126; rs6591272; rs7947754; rs5019163; rs1871031; rs4930471; rs2514063; rs4569014; rs4930472; rs12295420; rs2251281; rs10791909; rs9787887; rs6591271; rs9736142; rs3741179; rs2514060; rs4930465; rs1551887; rs1871032; rs1979376; rs1979375; rs11603033; rs6591269; rs7934566; rs11821703; rs2514056; rs2514057; rs1140670; rs2447571; rs12292126; rs1131740; rs12278968; rs17856219; rs1051493; rs4646818; rs2514019; rs4587733; rs7483770; rs4646821; rs28887499; rs2447570; rs2514058; rs35431164; rs7944424; rs34589365; rs3191912; rs2514059; rs34763154; rs2514062; rs4930474; rs4646820; rs4581451; rs4646822; rs35843427; rs34926854; rs34057662; rs12361092; rs35632190; rs35691462; rs4646819; rs7483773; rs12288316; rs2447598; rs35605762; rs36154763; rs1131725; rs12272679; rs3928535; rs4930475; rs5019164; rs2447593; rs11227878; rs4646827; rs2126716; rs12285813; rs7943880; rs28819504; rs34264835; rs3741177; rs5792425; rs12807294; rs4244825; rs4646824; rs5792424; rs4646825; rs33990300; rs11826930; rs12574701; rs12294545; rs11824747; rs10736660; rs11828473; rs12272021; rs12288023; rs12363825; rs2054409; rs2447597; rs2509720; rs2514024; rs2514025; rs2885171; rs4930211; rs4930212; rs4930463; rs4930464; rs6591267; rs7108411

# Metabolic_Enzyme_15_General_References:
7484374; 8890755

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5321

# Metabolic_Enzyme_16_Name:
Serum paraoxonase/lactonase 3

# Metabolic_Enzyme_16_Synonyms:
Not Available

# Metabolic_Enzyme_16_Gene_Name:
PON3

# Metabolic_Enzyme_16_Protein_Sequence:
>Serum paraoxonase/lactonase 3
MGKLVALVLLGVGLSLVGEMFLAFRERVNASREVEPVEPENCHLIEELESGSEDIDILPS
GLAFISSGLKYPGMPNFAPDEPGKIFLMDLNEQNPRAQALEISGGFDKELFNPHGISIFI
DKDNTVYLYVVNHPHMKSTVEIFKFEEQQRSLVYLKTIKHELLKSVNDIVVLGPEQFYAT
RDHYFTNSLLSFFEMILDLRWTYVLFYSPREVKVVAKGFCSANGITVSADQKYVYVADVA
AKNIHIMEKHDNWDLTQLKVIQLGTLVDNLTVDPATGDILAGCHPNPMKLLNYNPEDPPG
SEVLRIQNVLSEKPRVSTVYANNGSVLQGTSVASVYHGKILIGTVFHKTLYCEL

# Metabolic_Enzyme_16_Number_of_Residues:
354

# Metabolic_Enzyme_16_Molecular_Weight:
39608

# Metabolic_Enzyme_16_Theoretical_pI:
5.10

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  arylesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Metabolic_Enzyme_16_General_Function:
Not Available

# Metabolic_Enzyme_16_Specific_Function:
Has very limited arylesterase and no paraoxonase activities but rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents

# Metabolic_Enzyme_16_Pathway:
Not Available

# Metabolic_Enzyme_16_Reaction:
Not Available

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF01731:Arylesterase

# Metabolic_Enzyme_16_Signals:
1-

# Metabolic_Enzyme_16_Transmembrane_Regions:
5-24

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 3.1.1.2;EC 3.1.8.1

# Metabolic_Enzyme_16_GenBank_ID_Protein:
12751374

# Metabolic_Enzyme_16_SwissProt_ID:
PON3_HUMAN (Q15166)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
PON3

# Metabolic_Enzyme_16_Geneatlas_id:
PON3

# Metabolic_Enzyme_16_hgnc_id:
HGNC:9206

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_16_Gene_Sequence:
>1064 bp
ATGGGGAAGCTCGTGGCGCTGGTCCTGCTGGGGGTCGGCCTGTCCTTAGTCGGGGAGATG
TTCCTGGCGTTTAGAGAAAGGGTGAATGCCTCTCGAGAAGTGGAGCCAGTAGAACCTGAA
AACTGCCACCTTATTGAGGAACTTGAAAGTGGCTCTGAAGATATTGATATATTCCTCAGT
GGGCTGGCTTTTATCTCCAGTGGATTAAAATATCCAGGCATGCCAAACTTTGCGCCAGAT
GAACCAGGAAAAATCTTCTTGATGGATCTGAATGAACAAAACCCAAGGGCACAAGCACTA
GAAATCAGTGGTGGATTTGACAAAGAATTATTTAATCCACATGGGATCAGTATTTTCATC
GACAAAGACAATACTGTGTATCTTTATGTTGTGAATCATCCCCACATGAAGTCCACTGTG
GAGATATTTAAATTTGAGGAACAACAACGTTCTCTGGTATACCTGAAAACTATAAAACAT
GAACTTCTCAAAAGTGTGAATGACATTGTGGTTCTTGGACCAGAACAGTTCTATGCCACC
AGAGACCACTATTTTACCAACTCCCTCCTGTCATTTTTTGAGATGATCTTGGATCTTCGC
TGGACTTATGTTCTTTTCTACAGCCCAAGGGAGGTTAAAGTGGTGGCCAAAGGATTTTGT
AGTGCCAATGGGATCACAGTCTCAGCAGACCAGAAGTATGTCTATGTAGCTGATGTAGCA
GCTAAGAACATTCACATAATGGAAAAACATGATAACTGGGATTTAACTCAACTGAAGGTG
ATACAGTTGGGCACCTTAGTGGATAACCTGACTGTCGATCCTGCCACAGGAGACATTTTG
GCAGGATGCCATCCTAATCCTATGAAGCTACTGAACTATAACCCTGAGGACCCTCCAGGA
TCAGAAGTACTTCGCATCCAGAATGTTTTGTCTGAGAAGCCCAGGGTGAGCACCGTGTAT
GCCAACAATGGCTCTGTGCTTCAGGGCACCTCTGTGGCTTCTGTGTACCATGGGAAAATT
CTCATAGGCACCGTATTTCACAAAACTCTGTACTGTGAGCTCTA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
AF320003

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_16_Locus:
7q21.3

# Metabolic_Enzyme_16_SNPs:
rs17883013; rs1053275; rs13226149; rs17879114; rs17885558; rs757905; rs2375002; rs740264; rs11980413; rs6977389; rs2074353; rs11970910; rs2057682; rs468; rs7779960; rs9641162; rs10808092; rs6946761; rs2074352; rs7807131; rs3757708; rs12534317; rs10487131; rs17884000; rs10953145; rs7778771; rs978903; rs3735587; rs10953143; rs10487132; rs7797694; rs10953146; rs17166859; rs11972988; rs17166861; rs7787187; rs11768074; rs17886518; rs17882874; rs17774169; rs17883750; rs17882656; rs17878595; rs17885520; rs17880412; rs17881310; rs17879649; rs17881183; rs17885341; rs10239444; rs7796605; rs17879692; rs17879725; rs17879891; rs17884104; rs17878798; rs1987726; rs17886074; rs7798025; rs17884044; rs17885396; rs17878924; rs17882417; rs17881155; rs17879131; rs17879949; rs10239294; rs17879761; rs17883791; rs17879931; rs17878619; rs17885715; rs17882644; rs9640632; rs17881059; rs17883258; rs17880289; rs2079444; rs17880600; rs17886059; rs17879480; rs2375004; rs17878661; rs17879129; rs17886092; rs2072199; rs17885294; rs17885614; rs17882955; rs17881085; rs17878952; rs17882519; rs17878448; rs11978302; rs17885157; rs17166860; rs2072200; rs11764079; rs11770903; rs11767787; rs17166858; rs17886036; rs17886586; rs17885453; rs17882539; rs17885439; rs17884226; rs1006522; rs17879866; rs17878827; rs2375003; rs17880470; rs17885576; rs17883235; rs17879616; rs35073929; rs4014704; rs17885577; rs17879584; rs11433699; rs12704793; rs17878647; rs17883838; rs17883824; rs13226415; rs17880986; rs4590372; rs17883077; rs17878893; rs7802498; rs17881614; rs4470943; rs10429065; rs4729188; rs35486199; rs35097770; rs35206180; rs17883761; rs36200982; rs17878638; rs17880217; rs36200976; rs17879939; rs17879079; rs17883823; rs17885861; rs17882341; rs35007097; rs34704069; rs17882691; rs1003504; rs34779716; rs17883276; rs17885214; rs17881251; rs12112856; rs17885374; rs4425687; rs34107793; rs17882562; rs17883078; rs34063317; rs17880176; rs2079443; rs17878870; rs17881120; rs35510461; rs34251122; rs34277693; rs17885966; rs34582490; rs17885651; rs28806617; rs17882411; rs11378129; rs17885907; rs17879069; rs17883550; rs17879912; rs34625078; rs17885924; rs12539168; rs34323584; rs13226339; rs17879836; rs11388951; rs17880498; rs17884011; rs17882643; rs17883723; rs10487130; rs10953142; rs11972564; rs11977702; rs11981299; rs13306702; rs17166845; rs17166850; rs17166854; rs17166856; rs17879277; rs17879517; rs34305047; rs3735586; rs4141217; rs7493; rs7785846; rs7794850; rs916864; rs9641161; rs9641164

# Metabolic_Enzyme_16_General_References:
12853948; 8661009

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5828

# Metabolic_Enzyme_17_Name:
Platelet-activating factor acetylhydrolase IB subunit alpha

# Metabolic_Enzyme_17_Synonyms:
PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha; Lissencephaly-1 protein; LIS-1

# Metabolic_Enzyme_17_Gene_Name:
PAFAH1B1

# Metabolic_Enzyme_17_Protein_Sequence:
>Plateletactivating factor acetylhydrolase IB subunit alpha
MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIR
LQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVF
SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ
GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV
RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE
TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK
TLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR

# Metabolic_Enzyme_17_Number_of_Residues:
410

# Metabolic_Enzyme_17_Molecular_Weight:
46638

# Metabolic_Enzyme_17_Theoretical_pI:
7.40

# Metabolic_Enzyme_17_GO_Classification:
Not Available

# Metabolic_Enzyme_17_General_Function:
Not Available

# Metabolic_Enzyme_17_Specific_Function:
Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing

# Metabolic_Enzyme_17_Pathway:
Not Available

# Metabolic_Enzyme_17_Reaction:
Not Available

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF08513:LisH;
PF00400:WD40

# Metabolic_Enzyme_17_Signals:
None

# Metabolic_Enzyme_17_Transmembrane_Regions:
None

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 3.1.1.47

# Metabolic_Enzyme_17_GenBank_ID_Protein:
349824

# Metabolic_Enzyme_17_SwissProt_ID:
LIS1_HUMAN (P43034)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
PAFAH1B1

# Metabolic_Enzyme_17_Geneatlas_id:
PAFAH1B1

# Metabolic_Enzyme_17_hgnc_id:
HGNC:8574

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Cytoplasm. Spindle. Nucleus; nuclear membrane (Potential). Note=Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes (By similarity). Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane

# Metabolic_Enzyme_17_Gene_Sequence:
>1233 bp
ATGGTGCTGTCCCAGAGACAACGAGATGAACTAAATCGAGCTATAGCAGATTATCTTCGT
TCAAATGGCTATGAAGAGGCATATTCAGTTTTTAAAAAGGAAGCTGAATTAGATGTGAAT
GAAGAATTAGATAAAAAGTATGCTGGTCTTTTGGAAAAAAAATGGACATCTGTTATTAGA
TTACAAAAGAAGGTTATGGAATTAGAATCAAAGCTAAATGAAGCAAAAGAAGAATTTACG
TCAGGTGGACCTCTTGGTCAGAAACGAGACCCAAAAGAATGGATTCCCCGTCCGCCAGAA
AAATATGCATTGAGTGGTCACAGGAGTCCAGTCACTCGAGTCATTTTCCATCCTGTGTTC
AGTGTTATGGTCTCTGCTTCAGAGGATGCTACAATTAAGGTGTGGGATTATGAGACTGGA
GATTTTGAACGAACTCTTAAAGGACATACAGACTCTGTACAGGACATTTCATTCGACCAC
AGCGGCAAGCTTCTGGCTTCCTGTTCTGCAGATATGACCATTAAACTATGGGATTTTCAG
GGCTTTGAATGCATCAGAACCATGCACGGCCATGACCACAATGTTTCTTCAGTAGCCATC
ATGCCCAATGGAGATCATATAGTGTCTGCCTCAAGGGATAAAACTATAAAAATGTGGGAA
GTGCAAACTGGCTACTGTGTGAAGACATTCACAGGACACAGAGAATGGGTACGTATGGTA
CGGCCAAATCAAGATGGCACTCTGATAGCCAGCTGTTCCAATGACCAGACTGTGCGTGTA
TGGGTCGTAGCAACAAAGGAATGCAAGGCTGAGCTCCGAGAGCATGAGCATGTGGTAGAA
TGCATTTCCTGGGCTCCAGAAAGCTCATATTCCTCCATCTCTGAAGCAACAGGATCTGAG
ACTAAAAAAAGTGGTAAACCTGGGCCATTCTTGCTGTCTGGATCCAGAGACAAGACTATT
AAGATGTGGGATGTCAGTACTGGCATGTGCCTTATGACCCTCGTGGGTCATGATAACTGG
GTACGTGGAGTTCTGTTCCATTCTGGGGGGAAGTTTATTTTGAGTTGTGCTGATGACAAG
ACCCTACGCGTATGGGATTACAAGAACAAGCGATGCATGAAGACCCTCAATGCGCATGAA
CACTTTGTTACCTCCTTGGATTTCCACAAGACGGCACCCTATGTCGTCACTGGCAGCGTA
GATCAAACAGTAAAAGTGTGGGAGTGCCGTTGA

# Metabolic_Enzyme_17_GenBank_ID_Gene:
L13385

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_17_Locus:
17p13.3

# Metabolic_Enzyme_17_SNPs:
rs1266475; rs6628; rs867092; rs7209748; rs11078280; rs9905797; rs1266470; rs9897253; rs2439998; rs16952324; rs9899704; rs11078281; rs7213173; rs6502385; rs10445281; rs9908889; rs4790356; rs9908626; rs9911447; rs7214105; rs11870877; rs12452637; rs7209407; rs12450893; rs8068673; rs7217392; rs8079534; rs12943652; rs9902409; rs9908610; rs12449668; rs12449535; rs8074698; rs6502400; rs8071069; rs1266471; rs1266474; rs2531855; rs2317293; rs11867265; rs2439997; rs8068571; rs7211338; rs7209087; rs10445259; rs9889349; rs12451340; rs9908515; rs2439996; rs8077856; rs4556824; rs7216462; rs7209580; rs7216860; rs8072378; rs12453353; rs2531856; rs11078273; rs8077732; rs2317297; rs1029743; rs1029744; rs7213463; rs2873426; rs12938775; rs7223411; rs7211841; rs758416; rs8081803; rs4790353; rs3213696; rs8064409; rs12602021; rs12453812; rs8077351; rs12941261; rs3785957; rs6502440; rs6502442; rs4790089; rs3785958; rs11078300; rs9910645; rs7207614; rs11078288; rs9894388; rs12450337; rs4790355; rs9910332; rs12450722; rs11078302; rs3213697; rs7213741; rs16952298; rs11871331; rs7223817; rs12603072; rs11078286; rs4790348; rs16952275; rs9908283; rs7225921; rs7207987; rs4790087; rs8067871; rs6502458; rs7211181; rs9908050; rs768064; rs7224765; rs4609889; rs12051777; rs16952294; rs9908658; rs8082331; rs7210936; rs8077138; rs12150218; rs9908064; rs12450481; rs7207159; rs11078285; rs7219436; rs6502460; rs8067353; rs12936143; rs7215780; rs7209145; rs7219416; rs12051858; rs8070018; rs4790352; rs6502449; rs7225738; rs7216704; rs4362427; rs16952308; rs1803915; rs11652104; rs10606544; rs12947002; rs34761973; rs12946581; rs8076702; rs1803914; rs8797; rs34116093; rs1063474; rs35041946; rs12941801; rs2873425; rs1050060; rs10712058; rs34513110; rs35382225; rs34471859; rs34224166; rs12939922; rs34932981; rs34032623; rs9897737; rs10690714; rs34683975; rs34083323; rs12946469; rs9900665; rs34068430; rs12944570; rs12942112; rs34432210; rs11361437; rs8065991; rs11867971; rs8064881; rs1803913; rs12452806; rs11432432; rs34280283; rs1266472; rs34818326; rs34817885; rs35852637; rs3213695; rs9674719; rs35954533; rs12939921; rs12103775; rs35847789; rs11445169; rs16952273; rs11867972; rs1050061; rs34411981; rs34442256; rs35408383; rs1266473; rs2317295; rs35496270; rs7224954; rs35849869; rs35567602; rs13343274; rs34898826; rs4790090; rs1803912; rs12452821; rs1049972; rs34840132; rs12944558; rs35434180; rs34641583; rs34435220; rs12945881; rs5818872; rs3029954; rs7221255; rs2317296; rs11396911; rs11394999; rs4790088; rs12950917; rs8068466; rs12947700; rs34079979; rs35854143; rs8080733; rs35831029; rs35081573; rs35905116; rs34643970; rs5818869; rs34948212; rs12946135; rs12051903; rs35907473; rs10599416; rs9797251; rs36008138; rs11434541; rs11428423; rs6502438; rs34838213; rs7223347; rs12943545; rs35332619; rs34972908; rs7219015; rs34997708; rs34038838; rs28583520; rs12943572; rs7212391; rs34591445; rs2301165; rs35801835; rs35391038; rs4790354; rs8080128; rs35632355; rs34267097; rs11445148; rs11868182; rs11385415; rs34302417; rs12944429; rs1142073; rs8070312; rs34241880; rs12951200; rs28423027; rs35673615; rs12948200; rs12947683; rs35191721; rs35722835; rs7212585; rs8075918; rs35847684; rs8074193; rs34291491; rs2058165; rs35065867; rs10639352; rs10582467; rs11394286; rs11439238; rs9908744; rs34334771; rs8067153; rs35904559; rs35463848; rs34088886; rs34493806; rs7221826; rs5818871; rs10688067; rs35740513; rs12051672; rs35606899; rs10667274; rs8074558; rs11354575; rs11397532; rs4790349; rs11299400; rs33938135; rs10580602; rs7218235; rs5818870; rs34906915; rs35556974; rs11653772; rs34069179; rs34857040; rs34276555; rs1003398; rs1003399; rs1045864; rs1109451; rs2240730; rs2240731; rs2240732; rs3210638; rs35509306; rs35994060; rs4790357; rs7212450; rs9635678; rs9893575; rs9900415

# Metabolic_Enzyme_17_General_References:
8355785; 9063735; 11163258; 11889140; 11940666; 10441340; 11502906

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5780

# Metabolic_Enzyme_18_Name:
Platelet-activating factor acetylhydrolase IB subunit beta

# Metabolic_Enzyme_18_Synonyms:
PAF acetylhydrolase 30 kDa subunit; PAF-AH 30 kDa subunit; PAF-AH subunit beta; PAFAH subunit beta

# Metabolic_Enzyme_18_Gene_Name:
PAFAH1B2

# Metabolic_Enzyme_18_Protein_Sequence:
>Plateletactivating factor acetylhydrolase IB subunit beta
MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWR
ELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEA
IVQLINTRQPQAKIIVLGLLPRGEKPNPLRQKNAKVNQLLKVSLPKLANVQLLDTDGGFV
HSDGAISCHDMFDFLHLTGGGYAKICKPLHELIMQLLEETPEEKQTTIA

# Metabolic_Enzyme_18_Number_of_Residues:
229

# Metabolic_Enzyme_18_Molecular_Weight:
25570

# Metabolic_Enzyme_18_Theoretical_pI:
5.80

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_18_Specific_Function:
Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit

# Metabolic_Enzyme_18_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_18_Reaction:
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF00657:Lipase_GDSL

# Metabolic_Enzyme_18_Signals:
None

# Metabolic_Enzyme_18_Transmembrane_Regions:
None

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 3.1.1.47

# Metabolic_Enzyme_18_GenBank_ID_Protein:
2081614

# Metabolic_Enzyme_18_SwissProt_ID:
PA1B2_HUMAN (P68402)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
PAFAH1B2

# Metabolic_Enzyme_18_Geneatlas_id:
PAFAH1B2

# Metabolic_Enzyme_18_hgnc_id:
HGNC:8575

# Metabolic_Enzyme_18_PDB_ID:
1FXW

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_18_Gene_Sequence:
>690 bp
ATGAGCCAAGGAGACTCAAACCCAGCAGCTATTCCGCATGCAGCAGAAGATATTCAAGGA
GATGACCGATGGATGTCTCAGCACAACAGATTTGTTTTGGACTGTAAAGACAAAGAGCCT
GATGTACTGTTCGTGGGAGACTCCATGGTGCAGTTAATGCAGCAATATGAGATATGGCGA
GAGCTTTTTTCCCCACTTCATGCACTGAATTTTGGAATTGGGGGAGATACAACAAGACAT
GTTTTGTGGAGACTAAAGAATGGAGAACTGGAGAATATTAAGCCTAAGGTCATTGTTGTC
TGGGTAGGAACAAATAACCACGAAAATACAGCAGAAGAAGTAGCAGGTGGGATCGAGGCC
ATTGTACAACTTATCAACACAAGGCAGCCACAGGCCAAAATCATTGTATTGGGTTTGTTA
CCTCGAGGTGAGAAACCCAATCCTTTGAGGCAAAAGAACGCCAAGGTGAACCAACTCCTC
AAGGTTTCGCTGCCGAAGCTTGCCAACGTGCAGCTCCTGGATACCGACGGGGGTTTTGTG
CACTCGGACGGTGCCATCTCCTGCCACGACATGTTTGATTTTCTGCATCTGACAGGAGGG
GGCTATGCAAAGATCTGCAAACCCCTGCATGAACTGATCATGCAGTTGTTGGAGGAAACA
CCTGAGGAGAAACAAACCACCATTGCCTGA

# Metabolic_Enzyme_18_GenBank_ID_Gene:
D63390

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_18_Locus:
11q23

# Metabolic_Enzyme_18_SNPs:
rs4938349; rs12419436; rs4938347; rs12420725; rs12419227; rs4938350; rs7116454; rs2008908; rs2306471; rs4938348; rs7115562; rs10466592; rs4936365; rs12417984; rs12275933; rs12287494; rs12419272; rs4938351; rs10892079; rs1871757; rs2127905; rs10790175; rs6589602; rs7122944; rs7112513; rs3736120; rs10790174; rs7940310; rs7123517; rs7950633; rs7128382; rs12291885; rs7931335; rs4936366; rs4938352; rs10892080; rs7924389; rs12420250; rs12418896; rs2622934; rs11216304; rs11216297; rs34452623; rs1842567; rs35697010; rs9971561; rs7938902; rs35565601; rs12279830; rs36063971; rs35147963; rs34339279; rs35795118; rs11420191; rs11464993; rs35543434; rs2735183; rs11449159; rs34799596; rs12281315; rs10466591; rs34729840; rs11448584; rs11463525; rs35084965; rs7109311; rs11216303; rs4288786; rs12271743; rs11216302; rs35139041; rs28606431; rs12800789; rs34086293; rs7940225; rs11327233; rs35065382; rs35641654; rs35812569; rs35900647; rs12281009; rs7940106; rs12794352; rs34309794; rs35090192; rs35520143; rs12420127; rs11216298; rs7482529; rs12287258; rs33974219; rs11216300; rs36017397; rs12418349; rs35039449; rs35412232; rs11343000; rs35500922; rs7939981; rs11418579; rs34197273; rs11216306; rs11216307; rs11216308; rs35312964; rs11216305; rs34713157; rs11216295; rs11216296; rs10892082; rs10892083; rs2622936; rs3741295; rs4936367; rs4938353; rs7112577

# Metabolic_Enzyme_18_General_References:
9144386

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5777

# Metabolic_Enzyme_19_Name:
Platelet-activating factor acetylhydrolase IB subunit gamma

# Metabolic_Enzyme_19_Synonyms:
PAF acetylhydrolase 29 kDa subunit; PAF-AH 29 kDa subunit; PAF-AH subunit gamma; PAFAH subunit gamma

# Metabolic_Enzyme_19_Gene_Name:
PAFAH1B3

# Metabolic_Enzyme_19_Protein_Sequence:
>Plateletactivating factor acetylhydrolase IB subunit gamma
MSGEENPASKPTPVQDVQGDGRWMSLHHRFVADSKDKEPEVVFIGDSLVQLMHQCEIWRE
LFSPLHALNFGIGGDGTQHVLWRLENGELEHIRPKIVVVWVGTNNHGHTAEQVTGGIKAI
VQLVNERQPQARVVVLGLLPRGQHPNPLREKNRQVNELVRAALAGHPRAHFLDADPGFVH
SDGTISHHDMYDYLHLSRLGYTPVCRALHSLLLRLLAQDQGQGAPLLEPAP

# Metabolic_Enzyme_19_Number_of_Residues:
231

# Metabolic_Enzyme_19_Molecular_Weight:
25735

# Metabolic_Enzyme_19_Theoretical_pI:
6.84

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Not Available

# Metabolic_Enzyme_19_Specific_Function:
Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain

# Metabolic_Enzyme_19_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_19_Reaction:
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF00657:Lipase_GDSL

# Metabolic_Enzyme_19_Signals:
None

# Metabolic_Enzyme_19_Transmembrane_Regions:
None

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 3.1.1.47

# Metabolic_Enzyme_19_GenBank_ID_Protein:
1122219

# Metabolic_Enzyme_19_SwissProt_ID:
PA1B3_HUMAN (Q15102)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
PAFAH1B3

# Metabolic_Enzyme_19_Geneatlas_id:
PAFAH1B3

# Metabolic_Enzyme_19_hgnc_id:
HGNC:8576

# Metabolic_Enzyme_19_PDB_ID:
1FXW

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_19_Gene_Sequence:
>696 bp
ATGAGTGGAGAGGAGAACCCAGCCAGCAAGCCCACGCCGGTGCAGGACGTACAGGGCGAC
GGGCGCTGGATGTCCCTGCACCATCGGTTCGTGGCTGACAGCAAAGATAAGGAACCCGAA
GTCGTCTTCATCGGGGACTCCTTGGTCCAGCTCATGCACCAGTGCGAGATCTGGCGCGAG
CTCTTCTCTCCTCTGCATGCACTTAACTTTGGCATTGGTGGTGACGGCACACAGCATGTA
CTGTGGCGGCTGGAGAATGGGGAGCTGGAACACATCCGGCCCAAGATTGTGGTGGTCTGG
GTGGGCACCAACAACCACGGACACACAGCAGAGCAGGTGACTGGTGGCATCAAGGCCATT
GTGCAACTGGTGAATGAGCGACAGCCCCAGGCCCGGGTTGTGGTGCTGGGCCTGCTTCCG
CGAGGCCAACATCCCAACCCACTTCGGGAGAAGAACCGACAGGTGAACGAGCTGGTACGG
GCGGCACTGGCTGGCCACCCTCGGGCCCACTTCCTAGATGCCGACCCTGGCTTTGTGCAC
TCAGATGGCACCATCAGCCATCATGACATGTATGATTACCTGCATCTGAGCCGCCTGGGC
TACACACCTGTTTGCCGGGCTCTGCACTCCCTGCTTCTGCGTCTGCTGGCCCAAGACCAG
GGCCAAGGTGCTCCCCTGCTGGAGCCCGCACCCTAA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
D63391

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_19_Locus:
19q13.1

# Metabolic_Enzyme_19_SNPs:
Not Available

# Metabolic_Enzyme_19_General_References:
7669037

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
5532

# Metabolic_Enzyme_20_Name:
Aldehyde dehydrogenase X, mitochondrial precursor

# Metabolic_Enzyme_20_Synonyms:
Aldehyde dehydrogenase family 1 member B1; ALDH class 2

# Metabolic_Enzyme_20_Gene_Name:
ALDH1B1

# Metabolic_Enzyme_20_Protein_Sequence:
>Aldehyde dehydrogenase X, mitochondrial precursor
MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT
TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNLLADLVERDRVYLA
SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCG
QIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITG
YGPTAGAAIAQHMDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADM
EHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGP
QVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP
VQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHT
PFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS

# Metabolic_Enzyme_20_Number_of_Residues:
517

# Metabolic_Enzyme_20_Molecular_Weight:
57239

# Metabolic_Enzyme_20_Theoretical_pI:
6.79

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_20_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_20_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation

# Metabolic_Enzyme_20_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_20_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_20_Signals:
1-22

# Metabolic_Enzyme_20_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_20_GenBank_ID_Protein:
1263008

# Metabolic_Enzyme_20_SwissProt_ID:
AL1B1_HUMAN (P30837)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
ALDH1B1

# Metabolic_Enzyme_20_Geneatlas_id:
ALDH1B1

# Metabolic_Enzyme_20_hgnc_id:
HGNC:407

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_20_Gene_Sequence:
>1554 bp
ATGCTGCGCTTCCTGGCACCCCGGCTGCTTAGCCTCCAGGGCAGGACCGCCCTCTACTCC
TCGGCAGCAGCCCTCCCAAGCCCCATTCTGAACCCAGACATCCCCTACAACCAGCTGTTC
ATCAACAATGAATGGCAAGATGCAGTCAGCAAGAAGACCTTCCCGACGGTCAACCCTACC
ACCGGGGAGGTCATCGGGCACGTGGCTGAAGGTGACCGGGCTGATGTGGATCGGGCCGTG
AAAGCAGCCCGGGAAGCCTTCCGCCTGGGGTCCCCATGGCGCCGGATGGATGCCTCTGAG
CGGGGCCGGCTGCTGAACCTCCTGGCAGACCTAGTGGAGCGGGATCGAGTCTACTTGGCC
TCACTCGAGACCTTGGACAATGGGAAGCCTTTCCAAGAGTCTTACGCCTTGGACTTGGAT
GAGGTCATCAAGGTGTATCGGTACTTTGCTGGCTGGGCTGACAAGTGGCATGGCAAGACC
ATCCCCATGCATGGCCAGCATTTCTGCTTCACCCGGCATGAGCCCGTTGGTGTCTGTGGC
CAGATCATCCCGTGGAACTTCCCCTTGGTCATGCAGGGTTGGAAACTTGCCCCGGCACTC
GCCACAGGCAACACTGTGGTTATGAAGGTGGCAGAGCAGACCCCCCTCTCTGCCCTGTAT
TTGGCCTCCCTCATCAAGGAGGCAGGCTTTCCCCCTGGGGTGGTGAACATCATCACGGGG
TATGGCCCAACAGCAGGTGCGGCCATCGCCCAGCACATGGATGTTGACAAAGTTGCCTTC
ACCGGTTCCACCGAGGTGGGCCACCTGATCCAGAAAGCAGCTGGCGATTCCAACCTCAAG
AGAGTCACCCTGGAGCTGGGTGGTAAGAGCCCCAGCATCGTGCTGGCCGATGCTGACATG
GAGCATGCCGTGGAGCAGTGCCACGAAGCCCTGTTCTTCAACATGGGCCAGTGCTGCTGT
GCTGGCTCCCGGACCTTCGTGGAAGAATCCATCTACAATGAGTTTCTCGAGAGAACCGTG
GAGAAAGCAAAGCAGAGGAAAGTGGGGAACCCCTTTGAGCTGGACACCCAGCAGGGGCCT
CAGGTGGACAAGGAGCAGTTTGAACGAGTCCTAGGCTACATCCAGCTTGGCCAGAAGGAG
GGCGCAAAACTCCTCTGTGGCGGAGAGCGTTTCGGGGAGCGTGGTTTCTTCATCAAGCCT
ACTGTCTTTGGTGGCGTGCAGGATGACATGAGAATTGCCAAAGAGGAGATCTTTGGGCCT
GTGCAGCCCCTGTTCAAGTTCAAGAAGATTGAGGAGGTGGTTGAGAGGGCCAACAACACC
AGGTATGGCCTGGCTGCGGCTGTGTTCACCCGGGATCTGGACAAGGCCATGTACTTCACC
CAGGCACTCCAGGCCGGGACCGTGTGGGTAAACACCTACAACATCGTCACCTGCCACACG
CCATTTGGAGGGTTTAAGGAATCTGGAAACGGGAGGGAGCTGGGTGAGGATGGGCTTAAG
GCCTACACAGAGGTAAAGACGGTCACCATCAAGGTTCCTCAGAAGAACTCGTAA

# Metabolic_Enzyme_20_GenBank_ID_Gene:
M63967

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_20_Locus:
9p11.1

# Metabolic_Enzyme_20_SNPs:
rs2228093; rs4878199; rs2073478; rs2073477; rs2228094; rs3043; rs6476701; rs10758494; rs10758495; rs7859877; rs4646772; rs4646774; rs4878802; rs10738997; rs11555705; rs4646773; rs41278335; rs11555706; rs10973781; rs10973782; rs12343271; rs41278337; rs10118683; rs10758496; rs10814687; rs10973774; rs10973779; rs10973783; rs10973785; rs10973786; rs10973787; rs10973789; rs10973792; rs11361; rs11790480; rs11791018; rs11791622; rs12001093; rs12336048; rs12352007; rs12378762; rs13285234; rs13290293; rs1555480; rs1923423; rs1923424; rs2038589; rs34183602; rs35950473; rs4142260; rs4242647; rs4878203; rs4878800; rs4878801; rs4878804; rs4878805; rs4878806; rs4878807; rs4878808; rs4878809; rs4878811; rs6476703; rs7021469; rs7031628; rs7045542; rs7046137; rs7853954; rs7865905; rs7866277; rs7867383; rs911757; rs911758

# Metabolic_Enzyme_20_General_References:
2061311; 8244338

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
5530

# Metabolic_Enzyme_21_Name:
Aldehyde dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_21_Synonyms:
ALDH class 2; ALDHI; ALDH-E2

# Metabolic_Enzyme_21_Gene_Name:
ALDH2

# Metabolic_Enzyme_21_Protein_Sequence:
>Aldehyde dehydrogenase, mitochondrial precursor
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS

# Metabolic_Enzyme_21_Number_of_Residues:
517

# Metabolic_Enzyme_21_Molecular_Weight:
56382

# Metabolic_Enzyme_21_Theoretical_pI:
7.05

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_21_Specific_Function:
An aldehyde + NAD(+) + H(2)O = an acid + NADH

# Metabolic_Enzyme_21_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_21_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_21_Signals:
1-24

# Metabolic_Enzyme_21_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_21_GenBank_ID_Protein:
28606

# Metabolic_Enzyme_21_SwissProt_ID:
ALDH2_HUMAN (P05091)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
ALDH2

# Metabolic_Enzyme_21_Geneatlas_id:
ALDH2

# Metabolic_Enzyme_21_hgnc_id:
HGNC:404

# Metabolic_Enzyme_21_PDB_ID:
1OF7

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_21_Gene_Sequence:
>1551 bp
ATGTTGCGCGCTGCCGCCGCTCGGGCCCCGCCTGGCCGCCGCCTCTTGTCAGCCGCCGCC
ACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTTCATA
AACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACT
GGAGAGGTCATCTGTCAGGTAGCTGAAGGGGACAAGGAAGATGTGGACAAGGCACGTGAA
GGCCGCCCGGGCGCCTTCCAGCTGGGCTCACCTTGGCGCCGCATGGACGCATCACACAGC
GGCCGGCTGCTGAACCGCCTGGCCGATCTGATCGAGCGGGACCGGACCTACCTGGCGGCC
TTGGAGACCCTGGACAATGGCAAGCCCTATGTCATCTCCTACCTGGTGGATTTGGACATG
GTCCTCAAATGTCTCCGGTATTATGCCGGCTGGGCTGATAAGTACCACGGGAAAACCATC
CCCATTGACGGAGACTTCTTCAGCTACACACGCCATGAACCTGTGGGGGTGTGCGGGCAG
ATCATTCCGTGGAATTTCCCGCTCCTGATGCAAGCATGGAAGCTGGGCCCAGCCTTGGCA
ACTGGAAACGTGGTTGTGATGAAGGTAGCTGAGCAGACACCCCTCACCGCCCTCTATGTG
GCCAACCTGATCAAGGAGGCTGGCTTTCCCCCTGGTGTGGTCAACATTGTGCCTGGATTT
GGCCCCACGGCTGGGGCCGCCATTGCCTCCCATGAGGATGTGGACAAAGTGGCATTCACA
GGCTCCACTGAGATTGGCCGCGTAATCCAGGTTGCTGCTGGGAGCAGCAACCTCAAGAGA
GTGACCTTGGAGCTGGGGGGGAAGAGCCCCAACATCATCATGTCAGATGCCGATATGGAT
TGGGCCGTGGAACAGGCCCACTTCGCCCTGTTCTTCAACCAGGGCCAGTGCTGCTGTGCC
GGCTCCCGGACCTTCGTGCAGGAGGACATCTATGATGAGTTTGTGGTGCGGAGCGTTGCC
CGGGCCAAGTCTCGGGTGGTCGGGAACCCCTTTGATAGCAAGACCGAGCAGGGGCCGCAG
GTGGATGAAACTCAGTTTAAGAAGATCCTCGGCTACATCAACACGGGGAAGCAAGAGGGG
GCGAAGCTGCTGTGTGGTGGGGGCATTGCTGCTGACCGTGGTTACTTCATCCAGCCCACT
GTGTTTGGAGATGTGCAGGATGGCATGACCATCGCCAAGGAGGAGATCTTCGGGCCAGTG
ATGCAGATCCTGAAGTTCAAGACCATAGAGGAGGTTGTTGGGAGAGCCAACAATTCCACG
TACGGGCTGGCCGCAGCTGTCTTCACAAAGGATTTGGACAAGGCCAATTACCTGTCCCAG
GCCCTCCAGGCGGGCACTGTGTGGGTCAACTGCTATGATGTGTTTGGAGCCCAGTCACCC
TTTGGTGGCTACAAGATGTCGGGGAGTGGCCGGGAGTTGGGCGAGTACGGGCTGCAGGCA
TACACTGAAGTGAAAACTGTCACAGTCAAAGTGCCTCAGAAGAACTCATAA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
X05409

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_21_Locus:
12q24.2

# Metabolic_Enzyme_21_SNPs:
rs671; rs1062136; rs6490301; rs886205; rs2238151; rs968529; rs7296651; rs441; rs4767939; rs10744777; rs4646778; rs4767944; rs10849970; rs2158029; rs4646776; rs7312055; rs7311852; rs2238152; rs4646777; rs2283354; rs10774637; rs4648328; rs10774638; rs11609628; rs11066028; rs4646779; rs16941669; rs440; rs7397491; rs11834780; rs16941667; rs4646775; rs11066029; rs35154896; rs11066024; rs2106696; rs11613231; rs2158028; rs4767035; rs13306166; rs34083959; rs7136890; rs13306164; rs1064933; rs34477327; rs34884061; rs28633753; rs11442381; rs11615695; rs11066023; rs35511855; rs35781311; rs13306163; rs7397456; rs35050853; rs35642129; rs12312867; rs12829533; rs11407827; rs34480430; rs12314397; rs35264878; rs12813835; rs12322000; rs34896918; rs35650885; rs7970477; rs11066025; rs13306167; rs11066027; rs12301347; rs11614684; rs35700215; rs35746295; rs34587287; rs13306165; rs35786282; rs11066022; rs7397469; rs11066030; rs10450717; rs35693865; rs11503169; rs35546929; rs33973376; rs34497874; rs12830829; rs35061167; rs11609093; rs36073646; rs34108639; rs12824249; rs11610258; rs35147079; rs11613713; rs11066026; rs7486832; rs12099590; rs3832868; rs34300515; rs35212101; rs7398472; rs35239056; rs35752199; rs5800933; rs11613351; rs5023470; rs34587619; rs4646781; rs4646780; rs11304348; rs12305979; rs4646782; rs10849969; rs10849971; rs11066032; rs14630; rs2339839; rs2339840; rs7133964; rs737280; rs739580; rs7974339; rs7978737; rs9971942

# Metabolic_Enzyme_21_General_References:
3582651; 3562250; 2838413; 4065146; 2987944; 4015823; 3610592; 3653404; 6582480; 8561277; 10631996

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
5531

# Metabolic_Enzyme_22_Name:
Fatty aldehyde dehydrogenase

# Metabolic_Enzyme_22_Synonyms:
Aldehyde dehydrogenase, microsomal; Aldehyde dehydrogenase family 3 member A2; Aldehyde dehydrogenase 10

# Metabolic_Enzyme_22_Gene_Name:
ALDH3A2

# Metabolic_Enzyme_22_Protein_Sequence:
>Fatty aldehyde dehydrogenase
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE
VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ
PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH
IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT
CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI
AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA
LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS
HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV
KAEYY

# Metabolic_Enzyme_22_Number_of_Residues:
485

# Metabolic_Enzyme_22_Molecular_Weight:
54849

# Metabolic_Enzyme_22_Theoretical_pI:
7.99

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_22_Specific_Function:
Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length

# Metabolic_Enzyme_22_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_22_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_22_Signals:
None

# Metabolic_Enzyme_22_Transmembrane_Regions:
464-480

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_22_GenBank_ID_Protein:
1082036

# Metabolic_Enzyme_22_SwissProt_ID:
AL3A2_HUMAN (P51648)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
ALDH3A2

# Metabolic_Enzyme_22_Geneatlas_id:
ALDH3A2

# Metabolic_Enzyme_22_hgnc_id:
HGNC:403

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein; cytoplasmic side

# Metabolic_Enzyme_22_Gene_Sequence:
>1458 bp
ATGGAGCTCGAAGTCCGGCGGGTCCGACAGGCGTTCCTGTCCGGCCGGTCGCGACCTCTG
CGGTTTCGGCTGCAGCAGCTGGAGGCCCTGCGGAGGATGGTGCAGGAGCGCGAGAAGGAT
ATCCTGACGGCCATCGCCGCCGACCTGTGCAAGAGTGAATTCAATGTGTACAGTCAGGAA
GTCATTACTGTCCTTGGGGAAATTGATTTTATGCTTGAGAATCTTCCTGAATGGGTTACT
GCTAAACCAGTTAAGAAGAACGTGCTCACCATGCTGGATGAGGCCTATATTCAGCCACAG
CCTCTGGGAGTGGTGCTGATAATCGGAGCTTGGAATTACCCCTTCGTTCTCACCATTCAG
CCACTGATAGGAGCCATCGCTGCAGGAAATGCTGTGATTATAAAGCCTTCTGAACTGAGT
GAAAATACAGCCAAGATCTTGGCAAAGCTTCTCCCTCAGTATTTAGACCAGGATCTCTAT
ATTGTTATTAATGGTGGTGTTGAGGAAACCACGGAGCTCCTGAAGCAGCGATTTGACCAC
ATTTTCTATACGGGAAACACTGCGGTTGGCAAAATTGTCATGGAAGCTGCTGCCAAGCAT
CTGACCCCTGTGACTCTTGAACTGGGAGGGAAAAGTCCATGTTATATTGATAAAGATTGT
GACCTGGACATTGTTTGCAGACGCATAACCTGGGGAAAATACATGAATTGTGGCCAAACC
TGCATTGCACCCGACTATATTCTCTGTGAAGCATCCCTCCAAAATCAAATTGTATGGAAG
ATTAAGGAAACAGTGAAGGAATTTTATGGAGAAAATATAAAAGAGTCTCCTGATTATGAA
AGGATCATCAATCTTCGTCATTTTAAGAGGATACTAAGTTTGCTTGAAGGACAAAAGATA
GCTTTTGGTGGGGAGACTGATGAGGCCACACGCTACATAGCCCCAACAGTACTTACCGAT
GTTGATCCTAAAACCAAGGTGATGCAAGAAGAAATTTTTGGACCAATTCTTCCAATAGTG
CCTGTGAAAAATGTAGATGAGGCCATAAATTTCATAAATGAACGTGAAAAGCCTCTGGCT
CTTTATGTATTTTCGCATAACCATAAGCTCATCAAACGGATGATTGATGAGACATCCAGT
GGAGGTGTCACAGGCAATGACGTCATTATGCACTTCACGCTCAACTCTTTCCCATTTGGA
GGAGTGGGTTCCAGTGGGATGGGAGCTTATCACGGAAAACATAGTTTTGATACTTTTTCT
CATCAGCGTCCCTGTTTATTAAAAAGTTTAAAGAGAGAAGGTGCTAACAAACTCAGATAT
CCTCCCAACAGCCAGTCAAAGGTGGATTGGGGGAAATTTTTTCTCTTGAAACGGTTCAAC
AAAGAAAAACTCGGTCTCCTGTTGCTCACTTTCCTGGGTATTGTAGCCGCTGTGCTTGTC
AAGGCAGAATATTACTGA

# Metabolic_Enzyme_22_GenBank_ID_Gene:
L47162

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_22_Locus:
17p11.2

# Metabolic_Enzyme_22_SNPs:
rs7216; rs7503517; rs7215; rs16420; rs11204408; rs3786038; rs962801; rs2072333; rs1034897; rs2072331; rs2108971; rs1004490; rs1004491; rs4244600; rs962800; rs8069576; rs4925036; rs2072332; rs16960280; rs4646797; rs8069478; rs2386145; rs1800869; rs11204407; rs4646798; rs4646794; rs4925038; rs4646800; rs4925037; rs4646795; rs4646804; rs4646802; rs8073767; rs12937946; rs9910300; rs4646801; rs9901895; rs1034896; rs3760489; rs4621031; rs3888642; rs1057405; rs11548343; rs12947169; rs34160909; rs35364675; rs7209322; rs35495378; rs12947168; rs12708; rs4646805; rs7215552; rs35965955; rs2386146; rs35716578; rs34082599; rs4646799; rs4646796; rs3034928; rs1800870; rs35581449; rs5819686; rs34567842; rs34350257; rs34642385; rs4646793; rs11652177; rs4646907; rs34471504; rs8073053; rs2386147; rs6146012; rs34945824; rs36031953; rs34327718; rs35797108; rs34664206; rs4646803; rs35265843; rs36025724; rs35053333; rs3841513; rs34368630; rs4646806; rs35604266; rs16960266; rs28375263; rs11868363; rs11871420; rs11871642; rs12937179; rs1804608; rs2386144; rs34399035; rs34416664; rs35526408; rs4646807; rs4925026; rs8065688; rs8074204; rs8074500

# Metabolic_Enzyme_22_General_References:
8528251; 9027499; 9070922; 9254849; 9829906

# Metabolic_Enzyme_22_References:
Not Available

# Metabolic_Enzyme_23_ID:
5526

# Metabolic_Enzyme_23_Name:
4-trimethylaminobutyraldehyde dehydrogenase

# Metabolic_Enzyme_23_Synonyms:
TMABADH; Aldehyde dehydrogenase 9A1; Aldehyde dehydrogenase E3 isozyme; Gamma-aminobutyraldehyde dehydrogenase; R- aminobutyraldehyde dehydrogenase

# Metabolic_Enzyme_23_Gene_Name:
ALDH9A1

# Metabolic_Enzyme_23_Protein_Sequence:
>4trimethylaminobutyraldehyde dehydrogenase
MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA
AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY
AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK
PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI
MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI
LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY
VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA
AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL
KTVCVEMGDVESAF

# Metabolic_Enzyme_23_Number_of_Residues:
494

# Metabolic_Enzyme_23_Molecular_Weight:
53802

# Metabolic_Enzyme_23_Theoretical_pI:
5.61

# Metabolic_Enzyme_23_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_23_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_23_Specific_Function:
Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction

# Metabolic_Enzyme_23_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_23_Reaction:
4-trimethylammoniobutanal + NAD+ = 4-trimethylammoniobutanoate + NADH + H+

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_23_Signals:
None

# Metabolic_Enzyme_23_Transmembrane_Regions:
None

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 1.2.1.47;EC 1.2.1.3;EC

# Metabolic_Enzyme_23_GenBank_ID_Protein:
1049219

# Metabolic_Enzyme_23_SwissProt_ID:
AL9A1_HUMAN (P49189)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
ALDH9A1

# Metabolic_Enzyme_23_Geneatlas_id:
ALDH9A1

# Metabolic_Enzyme_23_hgnc_id:
HGNC:412

# Metabolic_Enzyme_23_PDB_ID:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_23_Gene_Sequence:
>1482 bp
ATGAGCACTGGCACCTTCGTCGTGTCGCAGCCGCTCAATTACCGCGGCGGGGCCGCTGGA
GCCGGCGGACGCTCCGGTACCGAGAAAGCTTTCGAGCCAGCAACCGGCCGAGTGATAGCT
ACTTTCACATGTTCAGGAGAAAAGGAAGTAAATTTGGCTGTTCAAAATGCAAAGGCTGCT
TTTAAAATATGGAGTCAAAAATCTGGCATGGAGCGTTGCCGAATCCTTTTGGAGGCTGCC
AGGATAATAAGGGAACGGGAGGATGAAATTGCTACTATGGAGTGCATCAACAATGGCAAG
TCCATCTTTGAGGCCCGCTTGGACATTGACATTTCCTGGCAGTGCCTGGAGTATTATGCG
GGCTTGGCTGCATCCATGGCTGGTGAACACATCCAGCTCCCAGGTGGATCGTTTGGTTAT
ACCAGAAGAGAACCACTTGGGGTATGTGTGGGAATAGGAGCATGGAACTACCCCTTTCAG
ATTGCCTCTTGGAAGTCGGCTCCAGCATTAGCCTGTGGTAATGCCATGGTCTTTAAACCT
TCTCCCTTTACACCTGTTTCTGCATTGCTACTGGCTGAAATCTACAGTGAGGCTGGTGTA
CCTCCTGGGCTCTTCAATGTGGTGCAGGGAGGGGCTGCCACAGGCCAGTTTCTGTGTCAG
CATCCCGATGTGGCCAAAGTCTCCTTCACTGGAAGTGTGCCCACTGGCATGAAGATCATG
GAGATGTCAGCTAAAGGAATCAAACCTGTTACCTTGGAACTTGGAGGCAAATCTCCACTC
ATCATCTTCTCAGACTGTGATATGAACAATGCTGTAAAGGGGGCGCTGATGGCCAACTTC
CTCACACAAGGCCAGGTTTGCTGTAATGGCACAAGAGTATTTGTGCAGAAAGAAATTCTT
GATAAATTTACAGAGGAAGTGGTGAAACAGACCCAAAGGATTAAAATTGGAGATCCCCTT
CTGGAAGATACAAGGATGGGTCCACTCATCAACCGACCACACCTGGAGCGAGTCCTTGGG
TTTGTCAAAGTGGCAAAGGAGCAGGGTGCTAAAGTGTTATGTGGTGGAGATATATATGTA
CCTGAAGATCCCAAATTAAAGGATGGATATTACATGAGACCTTGTGTATTAACTAATTGC
AGAGACGACATGACCTGTGTGAAGGAAGAGATCTTTGGGCCTGTTATGTCCATTTTATCA
TTTGACACTGAAGCTGAGGTTCTAGAAAGAGCCAATGATACCACTTTTGGACTAGCAGCT
GGCGTCTTTACCAGGGACATCCAACGGGCTCATAGAGTGGTAGCTGAGCTTCAGGCTGGG
ACGTGCTTCATTAACAACTATAACGTCAGCCCAGTGGAGTTGCCCTTTGGTGGATATAAG
AAGTCAGGATTTGGCAGAGAGAACGGCCGTGTGACAATCGAATATTATTCACAGCTGAAG
ACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGA

# Metabolic_Enzyme_23_GenBank_ID_Gene:
U34252

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_23_Locus:
1q23.1

# Metabolic_Enzyme_23_SNPs:
rs1065756; rs11808728; rs1143659; rs11506; rs12670; rs12408101; rs1913844; rs2882006; rs10753688; rs4646891; rs4646889; rs7516126; rs12565874; rs3820362; rs10800129; rs10800128; rs7534437; rs12072634; rs4656457; rs1337442; rs2348728; rs4578194; rs12080699; rs7541817; rs10918239; rs2348727; rs3738192; rs6683969; rs12065621; rs2348734; rs16849230; rs6426930; rs12083232; rs7513998; rs12122497; rs7555787; rs4646886; rs10800127; rs10918252; rs2348729; rs4646883; rs7518869; rs10800133; rs2176151; rs4646882; rs1538115; rs10800131; rs4646897; rs6690818; rs2050619; rs10753689; rs7546084; rs12076579; rs17482717; rs4657463; rs10918235; rs11587760; rs4274037; rs12567331; rs4557947; rs1337443; rs10800130; rs10800132; rs4646895; rs16849238; rs17450889; rs12033254; rs12069198; rs6657651; rs10918245; rs3845537; rs10918237; rs11807857; rs11807866; rs884121; rs4657462; rs10918236; rs7543204; rs2184918; rs12070650; rs17417191; rs9970857; rs6662419; rs7367737; rs10918242; rs10918241; rs7546322; rs4646888; rs16849374; rs12409168; rs12037790; rs10918247; rs7537071; rs12084748; rs10918238; rs7368130; rs2348730; rs10918244; rs4233407; rs12123278; rs4646892; rs4657466; rs4576644; rs6683651; rs6667075; rs12021795; rs6683665; rs12081464; rs7546215; rs7519162; rs10918240; rs6667088; rs6669697; rs12081903; rs4646885; rs7542184; rs16849479; rs4646887; rs12072664; rs10753687; rs4646896; rs10157944; rs6668102; rs3753893; rs4657468; rs3753892; rs7553712; rs7511691; rs7554409; rs7544840; rs6426928; rs6667681; rs4646881; rs1415503; rs11555775; rs9164; rs4646902; rs6667510; rs11555774; rs4307543; rs11436915; rs34948330; rs12139219; rs34495301; rs10918248; rs1890080; rs35894201; rs4646884; rs28759374; rs12137604; rs28589393; rs34662022; rs12354157; rs10918246; rs35087657; rs34105906; rs35913333; rs34664103; rs12083492; rs2271658; rs34872122; rs7512816; rs4646893; rs7527514; rs12566251; rs1970286; rs3831954; rs2348731; rs10918249; rs35178491; rs36027739; rs35864611; rs17416948; rs4646894; rs11583089; rs12742656; rs12754903; rs12742657; rs41267568; rs4646890; rs12084651; rs4646900; rs34304173; rs13376536; rs12727801; rs41326750; rs28439296; rs12134617; rs12036561; rs35531113; rs3845536; rs36011778; rs12090132; rs7525102; rs10918250; rs3738191; rs12239517; rs4646898; rs34072474; rs34945812; rs10918251; rs1890079; rs35439339; rs36150573; rs1577847; rs12728137; rs34846458; rs4646901; rs36110991; rs12083091; rs34894576; rs6426927; rs11458950; rs1856143; rs35757606; rs41267564; rs41267566; rs35742388; rs10494446; rs10494447; rs10800123; rs10800125; rs10800126; rs10800135; rs10800136; rs10918228; rs10918229; rs10918231; rs10918254; rs10918255; rs10918256; rs11579160; rs11800476; rs11810856; rs12027066; rs12028588; rs12043815; rs12044709; rs12060366; rs12143472; rs12748251; rs1547725; rs16848876; rs16848958; rs16849041; rs16849616; rs1878074; rs1878075; rs2090281; rs2297762; rs2297763; rs2297764; rs2297765; rs3753894; rs3795540; rs4147602; rs4147604; rs4147605; rs4147610; rs4147611; rs4341347; rs7527279; rs7549511; rs7551594; rs8133; rs9333483; rs9333487; rs9919190

# Metabolic_Enzyme_23_General_References:
8786138; 10702312; 8645224; 8269919; 2925663

# Metabolic_Enzyme_23_References:
Not Available

# Metabolic_Enzyme_24_ID:
5324

# Metabolic_Enzyme_24_Name:
Serum paraoxonase/arylesterase 2

# Metabolic_Enzyme_24_Synonyms:
PON 2; Serum aryldialkylphosphatase 2; A-esterase 2; Aromatic esterase 2

# Metabolic_Enzyme_24_Gene_Name:
PON2

# Metabolic_Enzyme_24_Protein_Sequence:
>Serum paraoxonase/arylesterase 2
MGAWVGCGLAGDRAGFLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN
GLAFFSVGLK
FPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTF
IDNDDTVYLFVVNHPEFKNTV
EIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFY
ATNDHYFSDPFLKYLETYLNLHWANVVYYSPN
EVKVVAEGFDSANGINISPDDKYIYVA
DILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIW
VGCHPNGQKLFVYDPN
NPPSSEVLRIQNILCEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRAL
YCEL

# Metabolic_Enzyme_24_Number_of_Residues:
354

# Metabolic_Enzyme_24_Molecular_Weight:
39398

# Metabolic_Enzyme_24_Theoretical_pI:
5.21

# Metabolic_Enzyme_24_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  arylesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Metabolic_Enzyme_24_General_Function:
Not Available

# Metabolic_Enzyme_24_Specific_Function:
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis

# Metabolic_Enzyme_24_Pathway:
map00361  gamma-Hexachlorocyclohexane degradation

# Metabolic_Enzyme_24_Reaction:
An aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol

# Metabolic_Enzyme_24_Pfam_Domain_Function:
PF01731:Arylesterase

# Metabolic_Enzyme_24_Signals:
1-

# Metabolic_Enzyme_24_Transmembrane_Regions:
None

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 3.1.1.2;EC 3.1.8.1

# Metabolic_Enzyme_24_GenBank_ID_Protein:
1333632

# Metabolic_Enzyme_24_SwissProt_ID:
PON2_HUMAN (Q15165)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
PON2

# Metabolic_Enzyme_24_Geneatlas_id:
PON2

# Metabolic_Enzyme_24_hgnc_id:
HGNC:9205

# Metabolic_Enzyme_24_PDB_ID:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Membrane; peripheral membrane protein

# Metabolic_Enzyme_24_Gene_Sequence:
>1065 bp

ATGGGGGCCTGGGTGGGCTGTGGGCTTGCTGGGGATCGCGCTGGCTTCCTGGGCGAGAG
GCTTCTGGCAC
TCAGAAATCGACTTAAAGCCTCCAGAGAAGTAGAATCTGTAGACCTTC
CACACTGCCACCTGATTAAAGG
AATTGAAGCTGGCTCTGAAGATATTGACATACTTCCC
AATGGTCTGGCTTTTTTTAGTGTGGGTCTAAAA
TTCCCAGGACTCCACAGCTTTGCACC
AGATAAGCCTGGAGGAATACTAATGATGGATCTAAAAGAAGAAA
AACCAAGGGCACGGG
AATTAAGAATCAGTCGTGGGTTTGATTTGGCCTCATTCAATCCACATGGCATCAG
CACT
TTCATAGACAACGATGACACAGTTTATCTCTTTGTTGTAAACCACCCAGAATTCAAGAAT
ACAGTG
GAAATTTTTAAATTTGAAGAAGCAGAAAATTCTCTGTTGCATCTGAAAACAGT
CAAACATGAGCTTCTTC
CAAGTGTGAATGACATCACAGCTGTTGGACCGGCACATTTCT
ATGCCACAAATGACCACTACTTCTCTGA
TCCTTTCTTAAAGTATTTAGGAACATACTTG
AACTTACACTGGGCAAATGTTGTTTACTACAGTCCAAAT
GAAGTTAAAGTGGTAGCAGA
AGGATTTGATTCAGCAAATGGGATCAATATTTCACCTGATGATAAGTATA
TCTATGTTG
CTGACATATTGGCTCATGAAATTCATGTTTTGGAAAAACACACTAATATGAATTTAACTC
A
GTTGAAGGTACTTGAGCTGGATACACTGGTGGATAATTTATCTATTGATCCTTCCTCG
GGGGACATCTGG
GTAGGCTGTCATCCTAATGGCCAGAAGCTCTTCGTGTATGACCCGAA
CAATCCTCCCTCGTCAGAGGTTC
TCCGCATCCAGAACATTCTATGTGAGAAGCCTACAG
TGACTACAGTTTATGCCAACAATGGGTCTGTTCT
CCAAGGAAGTTCTGTAGCCTCAGTG
TATGATGGGAAGCTGCTCATAGGCACTTTATACCACAGAGCCTTG
TATTGTGAACTCTA
A

# Metabolic_Enzyme_24_GenBank_ID_Gene:
L48513

# Metabolic_Enzyme_24_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_24_Locus:
7q21.3

# Metabolic_Enzyme_24_SNPs:
rs7493; rs12026; rs3918; rs17876172; rs17876183; rs2299264; rs2237585; rs987539; rs730365; rs2286232; rs2068604; rs2375005; rs2299263; rs9640633; rs6968305; rs740265; rs4729189; rs2057965; rs6961624; rs12704794; rs6973380; rs10487133; rs7801803; rs1639; rs3779492; rs2299267; rs17166875; rs17876116; rs2158806; rs11770901; rs12669182; rs17166879; rs3831552; rs10261470; rs17774346; rs11982486; rs7803148; rs2299266; rs17876129; rs2374993; rs10249263; rs2299265; rs10259688; rs10273532; rs6970627; rs11979545; rs7802018; rs730364; rs3735586; rs6961773; rs3216252; rs11981433; rs13438526; rs11976060; rs2286233; rs17876083; rs9641164; rs7785039; rs1034809; rs12155103; rs12704795; rs12534274; rs17876144; rs17876080; rs17876190; rs13245169; rs17876092; rs17876061; rs17876154; rs17876125; rs17876143; rs17876195; rs2040993; rs17876198; rs17876078; rs17876196; rs17876191; rs17876106; rs17876100; rs17876062; rs17876141; rs17876132; rs11323880; rs17876148; rs17876124; rs17879936; rs17876150; rs17876187; rs17876073; rs17876090; rs17876133; rs17876094; rs17876065; rs17876197; rs17876123; rs2237586; rs2057964; rs17876082; rs17876186; rs17876158; rs17876162; rs17876202; rs17876093; rs17876188; rs7794650; rs17876193; rs17876054; rs5885909; rs5885910; rs17876189; rs17876201; rs7785846; rs7785705; rs13306702; rs17166868; rs7786401; rs17876207; rs17876182; rs12704796; rs17876174; rs17876205; rs17876177; rs13306699; rs11545942; rs17876152; rs13306701; rs11545945; rs17876170; rs28376783; rs35210485; rs34396360; rs34242940; rs35432158; rs6964976; rs17876136; rs34903539; rs10694604; rs17876164; rs6968413; rs17876107; rs6465465; rs17876138; rs17876068; rs17876063; rs17876096; rs3216253; rs10264677; rs17876149; rs34766260; rs17876153; rs35269697; rs17876200; rs17876117; rs6978409; rs17876052; rs17876051; rs11413689; rs17876071; rs17876126; rs11451805; rs17717505; rs17876055; rs3046691; rs35930446; rs2040994; rs3831551; rs35686517; rs34077651; rs35310147; rs17876203; rs35234425; rs13306700; rs35284743; rs17876147; rs17876167; rs17876128; rs17876085; rs17876192; rs17876184; rs17876114; rs34561655; rs17876102; rs17876145; rs17876113; rs1034808; rs13223805; rs36033819; rs17876120; rs17876137; rs28530741; rs17876050; rs11767136; rs17876199; rs17876069; rs17876204; rs35852389; rs11283397; rs2068515; rs17876058; rs17876103; rs34057625; rs17876077; rs17883881; rs10257156; rs17876168; rs10224756; rs17876108; rs6946563; rs13242985; rs36229209; rs17166881; rs17876181; rs35216848; rs17876206; rs7805636; rs10674344; rs36229207; rs17169554; rs17876180; rs13243633; rs13242987; rs34196943; rs13243101; rs17876179; rs34718179; rs10686867; rs11974483; rs1006522; rs10260134; rs10953147; rs11764079; rs11767787; rs11770903; rs11977702; rs11981299; rs12535571; rs13226149; rs13233527; rs17879277; rs17879517; rs2072199; rs2072200; rs34305047; rs3757707; rs43037; rs43038; rs43039; rs43040; rs43041; rs43042; rs43044; rs6946850; rs6973282; rs6978425; rs7811616

# Metabolic_Enzyme_24_General_References:
8661009; 9714608; 12853948; 11579088; 9329371; 9443862

# Metabolic_Enzyme_24_References:
Not Available

# Metabolic_Enzyme_25_ID:
5829

# Metabolic_Enzyme_25_Name:
N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

# Metabolic_Enzyme_25_Synonyms:
Phosphatidylinositol-glycan biosynthesis class L protein; PIG-L

# Metabolic_Enzyme_25_Gene_Name:
PIGL

# Metabolic_Enzyme_25_Protein_Sequence:
>Nacetylglucosaminylphosphatidylinositol deNacetylase
MEAMWLLCVALAVLAWGFLWVWDSSERMKSREQGGRLGAESRTLLVIAHPDDEAMFFAPT
VLGLARLRHWVYLLCFSAGNYYNQGETRKKELLQSCDVLGIPLSSVMIIDNRDFPDDPGM
QWDTEHVARVLLQHIEVNGINLVVTFDAGGVSGHSNHIALYAAVRALHSEGKLPKGCSVL
TLQSVNVLRKYISLLDLPLSLLHTQDVLFVLNSKEVAQAKKAMSCHRSQLLWFRRLYIIF
SRYMRINSLSFL

# Metabolic_Enzyme_25_Number_of_Residues:
252

# Metabolic_Enzyme_25_Molecular_Weight:
28532

# Metabolic_Enzyme_25_Theoretical_pI:
8.23

# Metabolic_Enzyme_25_GO_Classification:
Not Available

# Metabolic_Enzyme_25_General_Function:
Not Available

# Metabolic_Enzyme_25_Specific_Function:
Involved in the second step of GPI biosynthesis. De-N- acetylation of N-acetylglucosaminyl-phosphatidylinositol

# Metabolic_Enzyme_25_Pathway:
Not Available

# Metabolic_Enzyme_25_Reaction:
6-(N-acetyl-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate

# Metabolic_Enzyme_25_Pfam_Domain_Function:
PF02585:PIG-L

# Metabolic_Enzyme_25_Signals:
1-17

# Metabolic_Enzyme_25_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_25_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_25_EC_Link:
EC 3.5.1.89

# Metabolic_Enzyme_25_GenBank_ID_Protein:
4239986

# Metabolic_Enzyme_25_SwissProt_ID:
PIGL_HUMAN (Q9Y2B2)

# Metabolic_Enzyme_25_swissprot_Name:
Not Available

# Metabolic_Enzyme_25_Genecard_id:
PIGL

# Metabolic_Enzyme_25_Geneatlas_id:
PIGL

# Metabolic_Enzyme_25_hgnc_id:
HGNC:8966

# Metabolic_Enzyme_25_PDB_ID:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_25_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein

# Metabolic_Enzyme_25_Gene_Sequence:
>759 bp
ATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGG
GTTTGGGACTCCTCAGAACGAATGAAGAGTCGGGAGCAGGGAGGACGGCTGGGAGCCGAA
AGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCCATGTTTTTTGCTCCCACA
GTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAAT
TACTACAATCAAGGAGAGACTCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGG
ATTCCACTCTCCAGTGTAATGATTATTGACAACAGGGATTTCCCAGATGACCCAGGCATG
CAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATC
AATCTGGTGGTGACTTTCGATGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTCTG
TATGCAGCTGTGAGGGCCCTGCACTCAGAAGGGAAGTTACCTAAAGGGTGCTCTGTGCTC
ACGCTTCAGTCTGTGAATGTGCTGCGCAAGTACATCTCCCTTCTGGATCTGCCCTTGTCT
CTGCTTCATACGCAGGATGTCCTCTTCGTGCTCAACAGCAAAGAAGTGGCACAGGCCAAG
AAAGCCATGTCCTGCCACCGCAGCCAGCTCCTCTGGTTCCGCCGCCTCTACATTATCTTC
TCCCGGTACATGAGAATCAACTCACTGAGCTTCCTCTGA

# Metabolic_Enzyme_25_GenBank_ID_Gene:
AB017165

# Metabolic_Enzyme_25_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_25_Locus:
17p12-p11.2

# Metabolic_Enzyme_25_SNPs:
rs15739; rs2302314; rs2014604; rs8077885; rs4792731; rs178785; rs10852834; rs2109262; rs4792728; rs4792730; rs178788; rs3785626; rs7210224; rs3112513; rs7219687; rs11868284; rs7210990; rs11650427; rs1029809; rs178791; rs3112511; rs4791665; rs11078338; rs1005380; rs1018364; rs4470185; rs7219038; rs2074995; rs6502499; rs9909022; rs9944524; rs11651578; rs3095171; rs178790; rs9914734; rs178787; rs17779879; rs9893005; rs2005835; rs7224367; rs178794; rs3785625; rs7215071; rs3112512; rs4791664; rs8069679; rs9910148; rs7225920; rs178796; rs9797124; rs12948905; rs3785622; rs2013857; rs9890539; rs4792726; rs7218342; rs9903871; rs11655325; rs12150285; rs2324306; rs11078337; rs178795; rs7225926; rs4588022; rs7217230; rs3785620; rs12945959; rs2324307; rs9901194; rs7217418; rs11871194; rs178792; rs9908081; rs6502498; rs4792729; rs12936233; rs12948244; rs11656811; rs12946619; rs10221252; rs7225649; rs9896275; rs3112510; rs7212650; rs7212903; rs7211819; rs11650956; rs3785624; rs8070979; rs12938397; rs8065649; rs11652044; rs9747114; rs3785623; rs12938394; rs11654658; rs7223428; rs9303135; rs8074727; rs764984; rs7211754; rs3785621; rs178793; rs1963811; rs7215673; rs12945855; rs35803470; rs12946511; rs35172054; rs35568368; rs34416574; rs3034004; rs35565381; rs28566930; rs12952668; rs34456796; rs12103479; rs8076400; rs34777606; rs9897061; rs3112514; rs36070251; rs34657944; rs12939090; rs34414046; rs11299226; rs35676198; rs34243048; rs9909941; rs7216781; rs34629340; rs34940044; rs12937203; rs34698708; rs11653500; rs35030168; rs34187120; rs34748399; rs10522327; rs8076724; rs3033989; rs5819562; rs36009074; rs8078533; rs12951660; rs12600944; rs8077876; rs35572629; rs11078336; rs12939543; rs11298241; rs35973689; rs12937205; rs8073259; rs11422750; rs36103182; rs12950571; rs4352085; rs34325866; rs11460317; rs7214301; rs12936529; rs11364104; rs35852993; rs34184162; rs9897070; rs9916220; rs7209811; rs34784588; rs35271065; rs12939078; rs9789072; rs34426136; rs35781493; rs8067404; rs35883694; rs11429532; rs7215583; rs28575753; rs34927087; rs36044246; rs5819561; rs35814080; rs2109258; rs35787320; rs34707095; rs12937182; rs34470162; rs11382153; rs7223807; rs11078335; rs35319034; rs7219665; rs7503498; rs3112515; rs178786; rs28516015; rs35895483; rs35667387; rs12938458; rs12939072; rs35703186; rs8066726; rs28622079; rs33911414; rs11382150; rs7219795; rs12602140; rs34110087; rs34331598; rs8067000; rs12938878; rs34479966; rs12946929; rs5015580; rs12952882; rs11653650; rs5819563; rs34962159; rs8068254; rs33994669; rs11650940; rs7219810; rs35909942; rs35730395; rs34743037; rs35458445; rs34694974; rs1985977; rs11435438; rs7219980; rs35821817; rs35901849; rs178789; rs8075636; rs8075655; rs10578326; rs35285920; rs12935928; rs12103680; rs34952168; rs34518917; rs12150564; rs35504589; rs34566690; rs34204371; rs35578509; rs34827519; rs11415569; rs10048156; rs35594899; rs11379081; rs7211515; rs12452870; rs34289173; rs36030857; rs8071289; rs35328073; rs10578327; rs28551630; rs9898510; rs9889720; rs34639894; rs11350245; rs11870456; rs4791666; rs2324305; rs12951442; rs12103478; rs12938858; rs9783845; rs2533007; rs34133338; rs12952432; rs9789071; rs34019457; rs35751075; rs34851411; rs9900232; rs12951388; rs28577957; rs34410992; rs7219335; rs11651955; rs11867824; rs12945877; rs1476810; rs178797; rs178798; rs2272775; rs3095169; rs34475723; rs7210068; rs7212874; rs9890867

# Metabolic_Enzyme_25_General_References:
10085243

# Metabolic_Enzyme_25_References:
Not Available

# Metabolic_Enzyme_26_ID:
5323

# Metabolic_Enzyme_26_Name:
Serum paraoxonase/arylesterase 1

# Metabolic_Enzyme_26_Synonyms:
PON 1; Serum aryldialkylphosphatase 1; A-esterase 1; Aromatic esterase 1; K-45

# Metabolic_Enzyme_26_Gene_Name:
PON1

# Metabolic_Enzyme_26_Protein_Sequence:
>Serum paraoxonase/arylesterase 1
MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDMEILPN
GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTF
TDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYG
TNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAEL
LAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPP
ASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL

# Metabolic_Enzyme_26_Number_of_Residues:
355

# Metabolic_Enzyme_26_Molecular_Weight:
39750

# Metabolic_Enzyme_26_Theoretical_pI:
4.89

# Metabolic_Enzyme_26_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  arylesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Metabolic_Enzyme_26_General_Function:
Not Available

# Metabolic_Enzyme_26_Specific_Function:
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. May mediate an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation

# Metabolic_Enzyme_26_Pathway:
map00361  gamma-Hexachlorocyclohexane degradation

# Metabolic_Enzyme_26_Reaction:
An aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol

# Metabolic_Enzyme_26_Pfam_Domain_Function:
PF01731:Arylesterase

# Metabolic_Enzyme_26_Signals:
1-

# Metabolic_Enzyme_26_Transmembrane_Regions:
None

# Metabolic_Enzyme_26_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_26_EC_Link:
EC 3.1.1.2;EC 3.1.8.1

# Metabolic_Enzyme_26_GenBank_ID_Protein:
190192

# Metabolic_Enzyme_26_SwissProt_ID:
PON1_HUMAN (P27169)

# Metabolic_Enzyme_26_swissprot_Name:
Not Available

# Metabolic_Enzyme_26_Genecard_id:
PON1

# Metabolic_Enzyme_26_Geneatlas_id:
PON1

# Metabolic_Enzyme_26_hgnc_id:
HGNC:9204

# Metabolic_Enzyme_26_PDB_ID:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_26_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_26_Gene_Sequence:
>1068 bp
ATGGCGAAGCTGATTGCGCTCACCCTCTTGGGGATGGGACTGGCACTCTTCAGGAACCAC
CAGTCTTCTTACCAAACACGACTTAATGCTCTCCGAGAGGTACAACCCGTAGAACTTCCT
AACTGTAATTTAGTTAAAGGAATCGAAACTGGCTCTGAAGACATGGAGATACTGCCTAAT
GGACTGGCTTTCATTAGCTCTGGATTAAAGTATCCTGGAATAAAGAGCTTCAACCCCAAC
AGTCCTGGAAAAATACTTCTGATGGACCTGAATGAAGAAGATCCAACAGTGTTGGAATTG
GGGATCACTGGAAGTAAATTTGATGTATCTTCATTTAACCCTCATGGGATTAGCACATTC
ACAGATGAAGATAATGCCATGTACCTCCTGGTGGTGAACCATCCAGATGCCAAGTCCACA
GTGGAGTTGTTTAAATTTCAAGAAGAAGAAAAATCGCTTTTGCATCTAAAAACCATCAGA
CATAAACTTCTGCCTAATTTGAATGATATTGTTGCTGTGGGACCTGAGCACTTTTATGGC
ACAAATGATCACTATTTTCTTGACCCCTACTTACAATCCTGGGAGATGTATTTGGGTTTA
GCGTGGTCGTATGTTGTCTACTATAGTCCAAGTGAAGTTCGAGTGGTGGCAGAAGGATTT
GATTTTGCTAATGGAATCAACATTTCACCCGATGGCAAGTATGTCTATATAGCTGAGTTG
CTGGCTCATAAGATTCATGTGTATGAAAAGCATGCTAATTGGACTTTAACTCCATTGAAG
TCCCTTGACTTTAATACCCTCGTGGATAACATATCTGTGGATCCTGAGACAGGAGACCTT
TGGGTTGGATGCCATCCCAATGGCATGAAAATCTTCTTCTATGACTCAGAGAATCCTCCT
GCATCAGAGGTGCTTCGAATCCAGAACATTCTAACAGAAGAACCTAAAGTGACACAGGTT
TATGCAGAAAATGGCACAGTGTTGCAAGGCAGTACAGTTGCCTCTGTGTACAAAGGGAAA
CTGCTGATTGGCACAGTGTTTCACAAAGCTCTTTACTGTGAGCTCTAA

# Metabolic_Enzyme_26_GenBank_ID_Gene:
M63012

# Metabolic_Enzyme_26_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_26_Locus:
7q21.3

# Metabolic_Enzyme_26_SNPs:
rs662; rs3917594; rs854560; rs854552; rs854551; rs3917575; rs3917577; rs3735590; rs3917576; rs854550; rs3917582; rs3917581; rs3917579; rs3917580; rs3917578; rs854568; rs854566; rs854569; rs2299260; rs854562; rs2237582; rs2299262; rs2272365; rs2237583; rs3917534; rs2299261; rs854563; rs854556; rs3917503; rs2049647; rs2269829; rs2049646; rs854557; rs854558; rs1157745; rs3917469; rs3917478; rs3917473; rs2074351; rs854561; rs2299256; rs3917498; rs3917521; rs3917549; rs3917537; rs3917524; rs2049649; rs2299255; rs854564; rs3917555; rs3917472; rs2057681; rs3917556; rs2301711; rs3917569; rs3917551; rs3917476; rs2074354; rs854565; rs3917477; rs2237584; rs3917514; rs3917529; rs3917539; rs3917538; rs3917550; rs3917490; rs3917475; rs3917502; rs3917548; rs3917559; rs854570; rs3917485; rs3917572; rs2299259; rs705378; rs854567; rs3917518; rs2237581; rs854553; rs3917558; rs2237580; rs3917541; rs3917564; rs2299257; rs854559; rs3917481; rs3917561; rs3917468; rs3917527; rs3917542; rs2158155; rs854555; rs3917532; rs17166810; rs3917492; rs3917500; rs3917471; rs3917533; rs3917596; rs3917590; rs3917493; rs3917467; rs7809060; rs3917525; rs3917547; rs3917491; rs2049648; rs3917562; rs10215036; rs3917566; rs3917563; rs4344018; rs3917528; rs3917510; rs3917509; rs3917536; rs17166812; rs3917557; rs11771594; rs3917568; rs3917570; rs3917506; rs3917483; rs3917517; rs3917545; rs3917571; rs3917589; rs3917488; rs3917515; rs854554; rs3917499; rs3917531; rs3917573; rs3917574; rs3917484; rs3917519; rs3917567; rs3917599; rs7792044; rs35409956; rs3917482; rs3917479; rs3917592; rs3917520; rs3917543; rs12669112; rs3917552; rs3917595; rs3917474; rs854549; rs705381; rs854571; rs854572; rs757158; rs705380; rs3917586; rs854573; rs705379; rs705382; rs3917464; rs3917463; rs3917583; rs3917601; rs3917466; rs3917584; rs13236941; rs13306698; rs35431117; rs13306695; rs3917600; rs3832528; rs3917512; rs3917494; rs5885907; rs33941136; rs34824830; rs4565398; rs3917597; rs11343146; rs3917535; rs3917591; rs10548570; rs3917546; rs3046663; rs3917513; rs3917598; rs1527723; rs3917553; rs10684571; rs41364245; rs10215712; rs28699500; rs34459620; rs10593904; rs3917522; rs4527804; rs3917511; rs28396660; rs5885906; rs36015658; rs36115777; rs3917523; rs3917508; rs3917516; rs5885904; rs3917489; rs3917486; rs3917505; rs3917504; rs34550136; rs35181743; rs3216251; rs3917588; rs5885905; rs1997230; rs34551559; rs3917544; rs3046658; rs35193664; rs3917530; rs35974860; rs28564906; rs3917540; rs4997889; rs2299258; rs3917487; rs35511949; rs3917507; rs35582633; rs3917560; rs3917495; rs34569909; rs34612855; rs13306696; rs11292716; rs3917593; rs35687400; rs10638749; rs34948808; rs10226158; rs11355011; rs10692484; rs34622204; rs2079088; rs34546681; rs3917470; rs34709624; rs7806699; rs3917496; rs3917501; rs3917565; rs3046669; rs3917526; rs17881027; rs6972570; rs3917465; rs3917587; rs35388471; rs34851166; rs3917585; rs10227092; rs10232531; rs11764692; rs11981667; rs12533898; rs13228784; rs17166759; rs17166761; rs17166818; rs17773605; rs4727312; rs8491; rs854542; rs854543; rs854544; rs854546; rs854547; rs854548; rs854574

# Metabolic_Enzyme_26_General_References:
1657140; 7916578; 8393742; 8393745; 8812495; 12853948; 8382160; 1718413; 1673382; 7638166; 8098250; 12783936

# Metabolic_Enzyme_26_References:
Not Available

# Metabolic_Enzyme_27_ID:
5830

# Metabolic_Enzyme_27_Name:
Aspartoacylase-2

# Metabolic_Enzyme_27_Synonyms:
Aminoacylase-3; ACY-3; Acylase III; Hepatitis C virus core-binding protein 1; HCBP1

# Metabolic_Enzyme_27_Gene_Name:
ACY3

# Metabolic_Enzyme_27_Protein_Sequence:
>Aspartoacylase2
MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRASFSAVPVLANPAATSG
CRRYVDHDLNRTFTSSFLNSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVLDLHNTTA
NMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKNGLGLELG
PQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPRTEAGHLA
GTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGVAFVQTEK
FTFTVPAMPALTPAPSPAS

# Metabolic_Enzyme_27_Number_of_Residues:
319

# Metabolic_Enzyme_27_Molecular_Weight:
35241

# Metabolic_Enzyme_27_Theoretical_pI:
5.77

# Metabolic_Enzyme_27_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_27_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_27_Specific_Function:
N-acyl-L-aspartate + H(2)O = a carboxylate + L-aspartate

# Metabolic_Enzyme_27_Pathway:
map00252  Alanine and aspartate metabolism;
 map00340  Histidine metabolism

# Metabolic_Enzyme_27_Reaction:
N-acyl-L-aspartate + H2O = a carboxylate + L-aspartate

# Metabolic_Enzyme_27_Pfam_Domain_Function:
PF04952:AstE_AspA

# Metabolic_Enzyme_27_Signals:
None

# Metabolic_Enzyme_27_Transmembrane_Regions:
None

# Metabolic_Enzyme_27_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_27_EC_Link:
EC 3.5.1.15

# Metabolic_Enzyme_27_GenBank_ID_Protein:
21654856

# Metabolic_Enzyme_27_SwissProt_ID:
ACY3_HUMAN (Q96HD9)

# Metabolic_Enzyme_27_swissprot_Name:
Not Available

# Metabolic_Enzyme_27_Genecard_id:
ACY3

# Metabolic_Enzyme_27_Geneatlas_id:
ACY3

# Metabolic_Enzyme_27_hgnc_id:
HGNC:24104

# Metabolic_Enzyme_27_PDB_ID:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_27_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_27_Gene_Sequence:
>960 bp
ATGTGCTCACTGCCTGTGCCCCGGGAGCCCCTGCGTCGCGTGGCTGTGACTGGGGGCACG
CATGGCAACGAGATGTCGGGCGTCTACCTGGCCCGGCACTGGCTGCATGCCCCCGCAGAG
CTGCAGAGAGCCAGCTTCTCCGCTGTGCCTGTGCTGGCCAACCCGGCAGCCACATCCGGC
TGCCGCCGCTACGTGGACCATGACCTCAACCGCACCTTCACCAGCAGCTTCCTCAATTCC
AGGCCCACCCCGGACGACCCATATGAGGTGACAAGAGCCCGAGAGCTGAACCAGCTGCTG
GGGCCCAAGGCCTCGGGCCAGGCCTTTGACTTTGTCCTTGACCTGCACAACACCACGGCC
AACATGGGCACCTGCTTAATCGCGAAGTCCTCCCACGAAGTCTTTGCCATGCACCTGTGC
CGCCATCTGCAGCTGCAGTACCCCGAGCTGTCCTGCCAGGTCTTCCTGTACCAGCGGTCT
GGGGAGGAGAGCTACAACCTGGACTCTGTGGCCAAAAATGGACTGGGTCTGGAGCTGGGC
CCCCAGCCACAGGGTGTGCTGCGGGCTGACATTTTCTCAAGGATGAGGACCCTGGTGGCC
ACAGTTCTGGACTTCATCGAACTCTTCAACCAGGGTACGGCCTTTCCTGCCTTTGAGATG
GAAGCCTATAGACCCGTGGGCGTCGTGGACTTCCCCCGCACCGAGGCCGGGCACCTGGCA
GGCACTGTGCATCCTCAGCTGCAGGACCGAGACTTCCAGCCACTGCAGCCTGGTGCTCCC
ATCTTCCAGATGTTCAGTGGGGAGGACCTGCTCTATGAGGGAGAGTCCACGGTGTACCCC
GTGTTCATTAACGAGGCTGCCTACTATGAGAAGGGCGTTGCCTTTGTCCAGACTGAGAAG
TTCACATTCACCGTGCCTGCCATGCCCGCGCTGACCCCTGCCCCGAGCCCAGCTTCCTAA


# Metabolic_Enzyme_27_GenBank_ID_Gene:
AY040761

# Metabolic_Enzyme_27_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_27_Locus:
11q13.2

# Metabolic_Enzyme_27_SNPs:
rs2290959; rs948445; rs34796596; rs17148450; rs948446; rs2514037; rs2514035; rs3888976; rs2509717; rs2290960; rs1111928; rs2252577; rs2514036; rs2509715; rs2514039; rs2514042; rs2509714; rs2514032; rs2290958; rs2447587; rs2514033; rs948444; rs10736660; rs2514030; rs2252727; rs7127140; rs2509718; rs2509719; rs2514034; rs34667730; rs3029248; rs2361141; rs2361140; rs1871038; rs34786387; rs3029257; rs1871040; rs1871039; rs7108759; rs34976152; rs7108760; rs3029250; rs2514044; rs34146083; rs2509716; rs2514043; rs2361142; rs4520603; rs2514038; rs2361139; rs12281770; rs2447584; rs3029253; rs2514041; rs3029299; rs34783536; rs2250568; rs2361143; rs2447582; rs34359416; rs35110105; rs2447586; rs34892473; rs2514031; rs34790058; rs35512546; rs7108422; rs35960754; rs34968171; rs10716389; rs5792422; rs2514045; rs36075390; rs3029215; rs10160824; rs11378613; rs3029301; rs2054410; rs11378612; rs35317019; rs34917403; rs2447580; rs34428407; rs34190423; rs10896189; rs11227870; rs11227871; rs11607368; rs11820792; rs11828473; rs12274519; rs12288023; rs12363825; rs12421572; rs12787511; rs12799342; rs12800028; rs1317934; rs1993839; rs2054409; rs2126720; rs2447589; rs2447590; rs2447591; rs2447597; rs2509711; rs2509712; rs2509713; rs2509720; rs2514022; rs2514024; rs2514027; rs2514028; rs2514029; rs2885171; rs35212875; rs3758938; rs3758939; rs4608079; rs4930210; rs4930211; rs4930212; rs4930463; rs4930464; rs6591267

# Metabolic_Enzyme_27_General_References:
Not Available

# Metabolic_Enzyme_27_References:
Not Available

# Metabolic_Enzyme_28_ID:
8643

# Metabolic_Enzyme_28_Name:
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

# Metabolic_Enzyme_28_Synonyms:
Glucosaminyl N-deacetylase/N-sulfotransferase 4; NDST- 4; N-heparan sulfate sulfotransferase 4; N-HSST 4[Includes: Heparan sulfate N-deacetylase 4

# Metabolic_Enzyme_28_Gene_Name:
NDST4

# Metabolic_Enzyme_28_Protein_Sequence:
>Bifunctional heparan sulfate Ndeacetylase/Nsulfotransferase 4
MNLIVKLRRSFRTLIVLLATFCLVSIVISAYFLYSGYKQEMTLIETTAEAECTDIKILPY
RSMELKTVKPIDTSKTDPTVLLFVESQYSQLGQDIIAILESSRFQYHMVIAPGKGDIPPL
TDNGKGKYTLVIYENILKYVSMDSWNRELLEKYCVEYSVSIIGFHKANENSLPSTQLKGF
PLNLFNNLALKDCFVNPQSPLLHITKAPKVEKGPLPGEDWTIFQYNHSTYQPVLLTELQT
EKSLSSLSSKTLFATVIQDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLSL
DRYILVDIDDIFVGKEGTRMNVKDVKALLETQNLLRTQVANFTFNLGFSGKFYHTGTEEE
DEGDDLLLRSVDEFWWFPHMWSHMQPHLFHNESSLVEQMILNKEFALEHGIPINMGYAVA
PHHSGVYPVHIQLYAAWKKVWGIQVTSTEEYPHLKPARYRKGFIHNSIMVLPRQTCGLFT
HTIFYKEYPGGPQELDKSIRGGELFLTILLNPISIFMTHLSNYGNDRLGLYTFVNLVNFV
QSWTNLKLQTLPPVQLAHQYFELFPEQKDPLWQNPCDDKRHKDIWSREKTCDHLPKFLVI
GPQKTGTTALYLFLLMHPSIISNLPSPKTFEEVQFFNGNNYHKGIDWYMDFFPTPSNTTS
DFLFEKSANYFHSEEAPRRAASLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALRFNF
YEVISTGHWAPSDLKTLQRRCLVPGWYAVHIERWLTYFATSQLLIIDGQQLRSDPATVMD
EVQKFLGVTPRYNYSEALTFDPQKGFWCQLLEGGKTKCLGKSKGRKYPPMDPESRTFLSN
YYRDHNVELSKLLHRLGQPLPSWLRQELQKVR

# Metabolic_Enzyme_28_Number_of_Residues:
872

# Metabolic_Enzyme_28_Molecular_Weight:
100717

# Metabolic_Enzyme_28_Theoretical_pI:
7.59

# Metabolic_Enzyme_28_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_28_General_Function:
Not Available

# Metabolic_Enzyme_28_Specific_Function:
Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity

# Metabolic_Enzyme_28_Pathway:
Not Available

# Metabolic_Enzyme_28_Reaction:
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine

# Metabolic_Enzyme_28_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_28_Signals:
1-29

# Metabolic_Enzyme_28_Transmembrane_Regions:
14-34

# Metabolic_Enzyme_28_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_28_EC_Link:
EC 2.8.2.8

# Metabolic_Enzyme_28_GenBank_ID_Protein:
11414892

# Metabolic_Enzyme_28_SwissProt_ID:
NDST4_HUMAN (Q9H3R1)

# Metabolic_Enzyme_28_swissprot_Name:
Not Available

# Metabolic_Enzyme_28_Genecard_id:
NDST4

# Metabolic_Enzyme_28_Geneatlas_id:
NDST4

# Metabolic_Enzyme_28_hgnc_id:
HGNC:20779

# Metabolic_Enzyme_28_PDB_ID:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_28_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_28_Gene_Sequence:
>2619 bp
ATGAATCTTATTGTGAAACTTCGGAGAAGTTTTCGAACATTGATTGTTCTCTTAGCTACC
TTTTGCTTGGTGAGCATTGTCATTTCTGCCTATTTTCTCTACTCTGGCTACAAACAGGAA
ATGACACTTATTGAAACCACTGCAGAAGCAGAATGCACTGACATCAAAATTCTACCATAT
AGGTCAATGGAGCTGAAAACAGTTAAACCTATTGACACATCCAAAACGGACCCTACTGTC
CTTCTCTTCGTGGAGAGCCAATACTCTCAACTCGGTCAAGATATCATAGCTATTTTGGAG
TCCAGCCGATTTCAGTACCACATGGTTATTGCCCCTGGAAAGGGAGATATACCTCCTCTT
ACAGATAATGGCAAAGGGAAATATACTTTAGTTATTTATGAAAATATTCTGAAGTATGTC
AGCATGGACTCATGGAATCGAGAGCTTTTAGAAAAATACTGTGTGGAATACAGTGTTAGT
ATAATCGGTTTTCATAAAGCCAATGAGAACAGCTTACCAAGTACACAATTAAAAGGCTTT
CCGTTAAACCTTTTCAATAATCTAGCTCTAAAGGACTGTTTTGTTAACCCTCAATCTCCT
TTGCTGCATATTACCAAAGCCCCCAAGGTTGAGAAAGGCCCTCTTCCTGGGGAAGACTGG
ACTATTTTCCAATATAATCATTCAACCTACCAGCCTGTACTTTTAACTGAGTTACAGACA
GAAAAATCCCTGTCATCCTTGTCTAGCAAAACACTCTTTGCAACGGTGATTCAGGATCTG
GGGCTTCATGATGGAATTCAGAGAGTACTTTTTGGCAACAACTTGAACTTTTGGCTGCAC
AAGCTCATCTTCATAGATGCCATCTCCTTCTTGTCAGGGAAGAGGCTGACATTGTCCTTG
GACAGGTACATCCTTGTGGACATTGATGATATATTTGTTGGGAAAGAGGGAACAAGGATG
AATGTCAAAGATGTGAAGGCATTACTAGAGACTCAAAATTTACTGCGCACTCAGGTTGCA
AATTTTACCTTCAACCTTGGATTTTCAGGGAAGTTTTACCACACAGGGACTGAAGAGGAA
GATGAAGGAGATGACCTTTTACTTCGGTCTGTGGATGAGTTCTGGTGGTTTCCTCACATG
TGGAGCCACATGCAGCCCCACCTCTTCCACAACGAGTCATCTTTAGTAGAGCAGATGATT
CTCAACAAGGAATTTGCACTGGAACATGGAATACCAATCAACATGGGCTATGCTGTGGCC
CCACATCACTCAGGGGTCTACCCGGTTCACATTCAGCTGTATGCAGCTTGGAAGAAGGTC
TGGGGTATTCAAGTCACCAGCACTGAAGAATATCCACATCTGAAACCTGCCCGGTACAGA
AAGGGCTTCATTCACAATAGCATCATGGTCCTCCCTCGACAGACTTGTGGGTTGTTCACT
CACACTATTTTCTACAAAGAATATCCAGGAGGACCCCAAGAACTGGATAAAAGTATCAGA
GGAGGTGAACTTTTTCTCACAATCCTTCTAAACCCAATCAGCATTTTCATGACCCATTTA
TCAAACTATGGAAATGACCGCCTAGGGTTATATACCTTTGTGAACTTGGTCAACTTTGTG
CAGAGCTGGACCAACCTGAAATTGCAAACTCTGCCTCCAGTGCAACTGGCCCACCAGTAT
TTTGAGCTCTTCCCTGAGCAGAAAGACCCTCTATGGCAGAATCCATGTGATGATAAACGA
CACAAAGACATCTGGTCCAGAGAGAAAACTTGTGACCACTTACCAAAATTTCTAGTAATT
GGTCCACAAAAAACAGGAACAACTGCACTTTATTTATTTCTTCTTATGCATCCTTCAATC
ATCAGCAATCTCCCTAGTCCAAAGACATTTGAGGAAGTTCAGTTCTTTAATGGCAACAAC
TATCACAAAGGAATAGACTGGTATATGGACTTTTTCCCTACACCATCCAATACTACAAGT
GACTTTCTGTTTGAAAAGAGTGCTAATTACTTCCATTCGGAAGAAGCTCCAAGACGAGCC
GCATCTCTTGTCCCCAAAGCCAAGATCATCACCATCCTCATTGACCCCTCAGACAGGGCA
TACTCTTGGTACCAGCACCAACGATCACATGAAGATCCAGCTGCTCTGAGGTTCAATTTC
TATGAAGTTATTTCAACAGGACATTGGGCTCCATCTGACTTAAAAACTTTGCAGAGAAGA
TGCCTAGTACCTGGATGGTATGCAGTCCACATAGAAAGATGGCTAACTTACTTTGCTACT
TCTCAGTTGCTAATTATTGATGGACAGCAGCTGAGATCTGACCCAGCTACTGTGATGGAT
GAAGTCCAGAAGTTTCTGGGAGTTACACCTCGTTATAATTACTCTGAAGCACTAACGTTT
GATCCCCAAAAGGGTTTTTGGTGTCAATTACTGGAAGGAGGAAAGACAAAATGCCTTGGA
AAAAGCAAAGGCCGAAAATATCCACCTATGGATCCAGAGTCTAGAACGTTCCTCTCTAAT
TACTACCGAGATCATAATGTGGAACTATCCAAACTGCTACACAGACTGGGACAGCCTCTG
CCATCGTGGCTGAGACAGGAACTGCAGAAAGTGAGATAG

# Metabolic_Enzyme_28_GenBank_ID_Gene:
AB036429

# Metabolic_Enzyme_28_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_28_Locus:
4q25-q26

# Metabolic_Enzyme_28_SNPs:
rs6843860; rs35449662; rs475441; rs2127460; rs562049; rs528282; rs473989; rs1382999; rs511497; rs551248; rs509777; rs532923; rs578131; rs563820; rs3114034; rs477208; rs7679114; rs493304; rs1479796; rs512355; rs1893120; rs505154; rs496992; rs510657; rs1824954; rs7667960; rs503256; rs530974; rs569105; rs521110; rs550608; rs483240; rs474314; rs569917; rs479087; rs581288; rs566198; rs484404; rs481915; rs512349; rs525972; rs529078; rs6533832; rs511198; rs504346; rs505277; rs480693; rs554772; rs13105185; rs486186; rs476739; rs486441; rs9996306; rs13104877; rs481751; rs514133; rs493237; rs528793; rs532137; rs477076; rs567227; rs17584636; rs11938603; rs6533834; rs558717; rs562874; rs11721621; rs10471004; rs540954; rs482641; rs508357; rs577897; rs563857; rs554840; rs506851; rs530934; rs480995; rs537144; rs536446; rs17047634; rs561210; rs11938912; rs505967; rs10001216; rs10020287; rs557687; rs503229; rs493796; rs17047653; rs490103; rs6849060; rs2620407; rs564876; rs1561728; rs2620412; rs525465; rs2583513; rs1479797; rs1866941; rs482683; rs481922; rs541329; rs2389043; rs524021; rs561736; rs566096; rs2620411; rs1904480; rs2583516; rs516638; rs511357; rs2046050; rs479321; rs279536; rs2583517; rs998359; rs279517; rs575703; rs494047; rs1372298; rs1837800; rs481667; rs2620408; rs516109; rs2620418; rs1479799; rs279511; rs499404; rs10002221; rs11098270; rs11931706; rs2018486; rs4834448; rs11939954; rs528983; rs279534; rs9999383; rs2583515; rs10011213; rs498347; rs1020218; rs9991654; rs531435; rs6815981; rs175926; rs6820993; rs6819616; rs6813054; rs9994258; rs538932; rs530616; rs518195; rs2165543; rs580214; rs495797; rs2620413; rs1471500; rs1020219; rs495990; rs279540; rs4404563; rs1441631; rs548896; rs12642789; rs11938588; rs2389042; rs4368622; rs7668760; rs558868; rs483675; rs10005762; rs9993907; rs279520; rs7675371; rs1441638; rs7669112; rs6533830; rs6833579; rs10006039; rs517079; rs11098273; rs2620401; rs279512; rs10012243; rs566388; rs279508; rs7671429; rs10014745; rs533950; rs279537; rs7654560; rs2620409; rs1441630; rs2389040; rs1441637; rs10009553; rs505696; rs12645876; rs9998568; rs279526; rs10015390; rs2620417; rs12642484; rs2389044; rs508583; rs2583514; rs2620424; rs7695449; rs4834447; rs7666328; rs1036757; rs6830598; rs7680119; rs6825790; rs7668694; rs10033537; rs279516; rs6856543; rs1866942; rs500409; rs279538; rs7694381; rs11931643; rs1899334; rs11736926; rs10030514; rs1552025; rs279541; rs2165542; rs7674443; rs2046051; rs11930174; rs7434687; rs11937330; rs569630; rs10516606; rs279528; rs12648274; rs10022934; rs570741; rs11934279; rs11944967; rs17047540; rs1583924; rs1036758; rs536511; rs11938645; rs13128968; rs6810550; rs511927; rs1441639; rs6819065; rs523325; rs11944889; rs6810779; rs279510; rs2620415; rs6812977; rs12645885; rs11941012; rs1842264; rs279519; rs1842263; rs979513; rs17622486; rs4082347; rs498426; rs2620410; rs531594; rs6856510; rs489558; rs10001338; rs573588; rs7671596; rs7670771; rs516919; rs17047475; rs11939952; rs11098271; rs279529; rs11931484; rs12507001; rs7665509; rs11943929; rs10516607; rs17584238; rs529320; rs547928; rs10004817; rs11946779; rs533155; rs4557280; rs279524; rs559670; rs522307; rs17047428; rs2620416; rs6830279; rs10009402; rs1383002; rs526459; rs7689254; rs2892670; rs7670030; rs10007513; rs17679264; rs6811104; rs6849371; rs2583521; rs6810786; rs2028481; rs1530271; rs6843204; rs17047437; rs9884962; rs9998272; rs10516608; rs10000924; rs279505; rs9998848; rs537512; rs6533829; rs1866943; rs6836056; rs11945934; rs9992854; rs499218; rs2389041; rs479528; rs6836349; rs509127; rs279521; rs1583922; rs2620399; rs568713; rs279509; rs1383001; rs2028482; rs10516605; rs2620431; rs13120543; rs2620423; rs6849898; rs12640065; rs17047470; rs2197074; rs482935; rs4472155; rs11936553; rs6844769; rs10026970; rs17047425; rs1583923; rs7671475; rs6811143; rs750417; rs528678; rs279506; rs279522; rs471867; rs10003023; rs7673947; rs7659210; rs12648047; rs550019; rs7656008; rs530167; rs17486477; rs515976; rs11943439; rs2019200; rs9784565; rs4264850; rs12647287; rs17679144; rs12645955; rs7689395; rs11947913; rs11941001; rs4554098; rs11944811; rs6854144; rs502179; rs11736417; rs9991699; rs6811822; rs7679194; rs515070; rs7437758; rs17047468; rs10016617; rs13108625; rs7689327; rs12642116; rs2197075; rs17047537; rs7654894; rs17047524; rs6848957; rs12642139; rs1899335; rs3899756; rs920577; rs11940539; rs2019195; rs279514; rs2218251; rs11939806; rs11940470; rs10857036; rs17047495; rs6419194; rs2583523; rs6858472; rs543088; rs7696060; rs279539; rs10049937; rs4336245; rs9762896; rs279531; rs4090780; rs11734611; rs17047508; rs4530655; rs11946971; rs2083626; rs17679276; rs279518; rs10013031; rs531263; rs9762847; rs2620406; rs6856689; rs11735531; rs11935037; rs12503383; rs511901; rs10001879; rs7687949; rs9992947; rs557173; rs6824591; rs12505140; rs1441628; rs279525; rs554915; rs7663228; rs1383000; rs9997949; rs279532; rs10026976; rs6810389; rs10014430; rs9995811; rs11936530; rs10002405; rs279513; rs10006683; rs279535; rs6850601; rs13138975; rs10029337; rs17047545; rs1978938; rs17623036; rs10004858; rs573421; rs6836286; rs530485; rs899606; rs17047529; rs10222995; rs6849570; rs6844231; rs9762854; rs567976; rs17047492; rs17047419; rs17047463; rs7676598; rs2119664; rs9999215; rs10222706; rs1001815; rs1837802; rs11727410; rs17047534; rs17622677; rs6830803; rs1441633; rs6830396; rs6838296; rs7440344; rs10004337; rs11942204; rs517231; rs533585; rs10030883; rs17622627; rs17047479; rs11931244; rs6812189; rs17583437; rs17486843; rs17679753; rs1479798; rs13115130; rs10008361; rs13131064; rs547427; rs17583766; rs17047431; rs2119663; rs7674844; rs17622816; rs2620400; rs7679531; rs9684691; rs13150766; rs1441632; rs279515; rs17047542; rs11930181; rs6823958; rs6815070; rs11098276; rs4607240; rs12511884; rs11728589; rs10014003; rs1441627; rs11725345; rs11939941; rs7669788; rs17047484; rs16997326; rs7673354; rs1471499; rs10003387; rs17047410; rs13142670; rs7680862; rs17486233; rs12511801; rs482283; rs35181627; rs34847662; rs34134859; rs34045479; rs34623369; rs13128123; rs28783717; rs34597527; rs13128093; rs13152590; rs475668; rs13112177; rs10635710; rs10693090; rs34472301; rs12512835; rs13152038; rs28587893; rs34956339; rs35614861; rs35591411; rs13106842; rs35104189; rs33935748; rs34087427; rs28722150; rs33991012; rs34226280; rs34528236; rs5861203; rs34184149; rs7657227; rs33975225; rs11460236; rs11938344; rs35031671; rs6858866; rs11426438; rs477958; rs10025785; rs9991325; rs33981511; rs34574421; rs7657463; rs28687855; rs35819963; rs10016860; rs10470913; rs10025233; rs35757521; rs28678017; rs35747634; rs36059350; rs35707843; rs9685915; rs4508907; rs1600397; rs559307; rs28695346; rs35574225; rs513782; rs34883816; rs35484731; rs13131643; rs34684234; rs10033025; rs475646; rs34924132; rs28854031; rs13106858; rs2019437; rs28549159; rs35924727; rs5861202; rs33939574; rs34309563; rs491934; rs13152037; rs34452990; rs34598173; rs35164085; rs35761925; rs486615; rs13152177; rs7689538; rs34879124; rs35674542; rs3132822; rs33935242; rs13149623; rs28623688; rs13142564; rs13134223; rs34850904; rs28690869; rs34942096; rs33925339; rs10679782; rs33926517; rs2620419; rs2620425; rs6858653; rs542287; rs13112166; rs35715981; rs12640620; rs11098279; rs34741219; rs12233877; rs35081042; rs2620421; rs11460393; rs35124044; rs13144414; rs35758538; rs13149368; rs34863507; rs6848295; rs33948499; rs28596780; rs1837805; rs2620426; rs35262784; rs9760742; rs693155; rs34688407; rs34389569; rs509591; rs6810460; rs10555403; rs28602418; rs35492732; rs28622422; rs33969019; rs34614261; rs2620420; rs7340931; rs28496867; rs10008033; rs7663777; rs13152100; rs11441566; rs13133429; rs2389061; rs11435788; rs9998053; rs35971842; rs9307410; rs10651752; rs11940938; rs34190385; rs35469679; rs2583522; rs5861197; rs13124861; rs1441635; rs169416; rs34667506; rs34741350; rs11098272; rs28647687; rs33984444; rs35350644; rs7684881; rs4507381; rs17047543; rs28470302; rs6814738; rs28654828; rs28634928; rs28841108; rs33987124; rs28454168; rs534014; rs28714338; rs35061218; rs28648377; rs538924; rs17047536; rs13149624; rs8180156; rs35363930; rs6848302; rs34104366; rs10591934; rs28433013; rs35208794; rs2583519; rs34171851; rs35992236; rs6857099; rs28635970; rs36229502; rs11433054; rs35645731; rs34231121; rs36126200; rs28654447; rs28792405; rs12501272; rs34661550; rs7679175; rs9761718; rs34477080; rs34843969; rs520853; rs35529253; rs28538937; rs9995994; rs11098280; rs10529608; rs28640895; rs34863366; rs35134439; rs34398191; rs28696823; rs13104082; rs34177084; rs35327124; rs34592796; rs6848946; rs17047462; rs34866154; rs13109524; rs6848955; rs35588669; rs28396645; rs35497695; rs9760743; rs28879144; rs11405644; rs36080386; rs28563786; rs2620427; rs35088938; rs4345205; rs1899336; rs34349158; rs28457274; rs6837725; rs33953343; rs28549023; rs188089; rs11460392; rs28560246; rs28521052; rs28564632; rs2583520; rs10019977; rs279507; rs28646187; rs34479190; rs1441629; rs11396814; rs28420758; rs35979278; rs28758805; rs3077815; rs28401715; rs28523432; rs28719532; rs9762553; rs2620402; rs33951232; rs35899989; rs10446725; rs13126512; rs5861198; rs28485691; rs994218; rs34353236; rs28583163; rs34357319; rs2218250; rs34549028; rs34705577; rs35995859; rs11432779; rs5861200; rs28369395; rs13146230; rs36211109; rs530306; rs35066832; rs28727452; rs10682093; rs10615758; rs1837801; rs28433673; rs2583511; rs578285; rs6814955; rs35247707; rs35295440; rs4834449; rs35819730; rs28472632; rs35888388; rs34181479; rs2620422; rs6833754; rs11286132; rs34174566; rs6837715; rs13145875; rs4833469; rs6826385; rs10007433; rs28700231; rs33910952; rs10003921; rs33944193; rs28769381; rs35832883; rs11724358; rs34251892; rs35350731; rs28448721; rs28408781; rs34109567; rs34860647; rs10008694; rs35097855; rs35631339; rs13145278; rs34933883; rs11292247; rs1940295; rs4645229; rs1441634; rs36090257; rs28472459; rs28710395; rs36203738; rs28681493; rs13125045; rs33962515; rs11418590; rs2620414; rs35907948; rs9760755; rs10008192; rs193368; rs35095762; rs4100071; rs7665791; rs28680952; rs33921813; rs5861199; rs28806557; rs36055187; rs34780585; rs13122736; rs28496574; rs1000257; rs35605369; rs11462506; rs11441565; rs17047476; rs28533489; rs11483232; rs35442965; rs13149569; rs28719699; rs11433053; rs34037873; rs33934132; rs10010498; rs13135342; rs33929512; rs13115201; rs2389060; rs35651844; rs10526679; rs35797094; rs3077771; rs3043339; rs35075605; rs9761733; rs13122240; rs9714620; rs1837803; rs28635347; rs35146605; rs3849031; rs10020187; rs4519811; rs9761735; rs13150562; rs28393555; rs13131620; rs34072502; rs6848951; rs34196996; rs10007951; rs34055166; rs36008114; rs28434241; rs10016571; rs34139012; rs6818268; rs33988343; rs35726786; rs5861201; rs6853328; rs28521255; rs2389045; rs2859941; rs1971146; rs28633393; rs35039526; rs7671346; rs17679009; rs28668946; rs35801992; rs28569252; rs13124066; rs28493518; rs35955171; rs35597057; rs4476618; rs34354852; rs13132103; rs34793357; rs34143696; rs28611498; rs6828951; rs35423038; rs34314240; rs17679126; rs28457694; rs6855342; rs34768339; rs4001837; rs36094936; rs12639904; rs34789347; rs4361406; rs35233146; rs35705864; rs12643704; rs35967011; rs10029780; rs28548820; rs7696723; rs35633534; rs279533; rs11932147; rs33976211; rs28498191; rs35652473; rs28404350; rs34241103; rs13150826; rs28465489; rs34279473; rs28490277; rs28525562; rs35516569; rs33919888; rs35676486; rs4306976; rs5861195; rs1837799; rs28892914; rs34682679; rs13136365; rs13150779; rs10006890; rs13104087; rs28410117; rs510247; rs34569627; rs28509283; rs28812915; rs34516136; rs34776826; rs28560123; rs2583518; rs34408777; rs28464565; rs6533831; rs17047446; rs33977537; rs34602372; rs28677056; rs12650241; rs12507013; rs1837804; rs35346250; rs538817; rs35451664; rs28729973; rs2620429; rs34940157; rs35889965; rs36040898; rs35017501; rs12511633; rs6839057; rs13435021; rs35777600; rs1479802; rs3043338; rs279527; rs10018730; rs35366318; rs10030524; rs33922369; rs28612407; rs11931805; rs10654638; rs28434781; rs2127461; rs33917382; rs12641102; rs5861194; rs7663241; rs1561729; rs4834446; rs13152092; rs560680; rs486022; rs573772; rs35075359; rs35047155; rs279530; rs28730954; rs28874071; rs34412219; rs35890208; rs4361407; rs10593709; rs35536995; rs7690267; rs2583524; rs28727924; rs35903634; rs6844298; rs28412091; rs2620428; rs9759996; rs35995903; rs34207802; rs34265214; rs28773816; rs28488142; rs518872; rs13121181; rs10471002; rs35736377; rs9761726; rs28576070; rs35631469; rs36015004; rs33968646; rs6830220; rs4090781; rs34746303; rs34148880; rs17047442; rs6839089; rs279523; rs28622250; rs5861196; rs5027259; rs7693904; rs13150592; rs34909171; rs35749618; rs28587008; rs10591935; rs11350168; rs35830702; rs35473639; rs34275245; rs33922572; rs3840986; rs4299604; rs3840987; rs10013732; rs10013791; rs10013926; rs11936613; rs12640672; rs12646496; rs12646770; rs13103789; rs35438297; rs3898306; rs4512014; rs4574434; rs4640690; rs481502; rs483276; rs518645; rs528860; rs534254; rs547260; rs559777; rs560820; rs6533822; rs7682531

# Metabolic_Enzyme_28_General_References:
11087757

# Metabolic_Enzyme_28_References:
Not Available

# Metabolic_Enzyme_29_ID:
8700

# Metabolic_Enzyme_29_Name:
Hypothetical protein DKFZp666F229

# Metabolic_Enzyme_29_Synonyms:
Not Available

# Metabolic_Enzyme_29_Gene_Name:
DKFZp666F229

# Metabolic_Enzyme_29_Protein_Sequence:
>Hypothetical protein DKFZp666F229
DDLYHWSVESYSDFWAEFWKFSGIVFSRVYDEVVDTSKGIADVPEWFKGSRLNYAENLLR
HKENDRVALYIAREGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGDRVVGYLPNSEHAV
EAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHNHMEKLQQVV
KGLPDLKKVVVIPYVSSRENIDLSKIPNSVFLDDFLATGTSEQAPQLEFEQLPFSHPLFI
MFSSGTTGAPKCMVHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVGWMMWNWMVSLLAT
GAAMVLYDGSPLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEEKAMKPVETHSLQMLHTI
LSTGSPLKAQSYEYVYRCIKSSILLGSISGGTDIISCFMGHNFSLPVYKGEIQARNLGMA
VEAWNEEGKAVWGESGELVCTKPIPCQPTHFWNDENGNKYRKAYFSKFPGIWAHGDYCRI
NPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERVILFL
KMASGHAFQPDLVKRIRDAIRMGLSARHVPSLILETKGIPYTLNGKKVEVAVKQIIAGKA
VEQGGAFSNPETLDLYRDIPELQGF

# Metabolic_Enzyme_29_Number_of_Residues:
625

# Metabolic_Enzyme_29_Molecular_Weight:
69801

# Metabolic_Enzyme_29_Theoretical_pI:
6.37

# Metabolic_Enzyme_29_GO_Classification:
>>>
 Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-sulfur bonds
Function:  CoA-ligase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  isoprenoid metabolism
Process:  isoprenoid biosynthesis
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_29_General_Function:
Lipid transport and metabolism

# Metabolic_Enzyme_29_Specific_Function:
Not Available

# Metabolic_Enzyme_29_Pathway:
Not Available

# Metabolic_Enzyme_29_Reaction:
Not Available

# Metabolic_Enzyme_29_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_29_Signals:
1-303

# Metabolic_Enzyme_29_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_29_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_29_EC_Link:
EC 6.2.1.16

# Metabolic_Enzyme_29_GenBank_ID_Protein:
52545788

# Metabolic_Enzyme_29_SwissProt_ID:
Q658Q8_HUMAN (Q658Q8)

# Metabolic_Enzyme_29_swissprot_Name:
Not Available

# Metabolic_Enzyme_29_Genecard_id:
DKFZp666F229

# Metabolic_Enzyme_29_Geneatlas_id:
DKFZp666F229

# Metabolic_Enzyme_29_hgnc_id:
HGNC:21298

# Metabolic_Enzyme_29_PDB_ID:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_29_Subcellular_Location:
Not Available

# Metabolic_Enzyme_29_Gene_Sequence:
>1878 bp
GATGACTTGTACCATTGGTCCGTTGAGTCATATTCAGACTTCTGGGCAGAGTTCTGGAAA
TTCAGTGGAATTGTCTTCTCACGTGTGTATGATGAGGTTGTGGACACATCGAAAGGAATC
GCAGATGTCCCCGAGTGGTTCAAAGGCAGTCGGCTCAACTATGCAGAAAACCTCCTGCGG
CACAAAGAGAATGACAGAGTTGCCCTTTACATTGCAAGGGAAGGCAAAGAGGAAATTGTG
AAGGTGACTTTTGAAGAGCTGAGGCAAGAAGTGGCTTTGTTTGCAGCAGCAATGAGGAAA
ATGGGTGTGAAGAAAGGAGATCGGGTTGTTGGTTATTTACCCAACAGTGAGCACGCTGTC
GAGGCGATGCTGGCTGCGGCAAGCATTGGTGCCATCTGGAGCTCCACGTCCCCGGACTTC
GGTGTGAATGGTGTGCTGGACCGGTTTTCTCAAATTCAGCCAAAGCTCATCTTCTCTGTG
GAGGCTGTTGTCTATAATGGCAAAGAGCACAACCACATGGAAAAGCTGCAGCAGGTGGTT
AAAGGCCTACCAGACTTGAAGAAAGTGGTGGTGATTCCTTATGTGTCCTCCAGAGAGAAC
ATAGACCTTTCAAAGATTCCAAACAGTGTGTTTCTGGATGACTTTCTTGCCACCGGCACC
AGTGAGCAGGCCCCGCAGCTGGAGTTCGAGCAGCTGCCCTTCAGCCACCCACTGTTCATC
ATGTTCTCATCGGGCACCACGGGCGCACCCAAGTGCATGGTGCATTCCGCTGGGGGCACC
CTCATCCAGCATCTGAAGGAGCACCTGCTGCACGGCAACATGACCAGCAGTGACATCCTC
CTGTGCTACACCACGGTCGGCTGGATGATGTGGAACTGGATGGTGTCCCTTCTGGCCACA
GGAGCGGCCATGGTCTTGTACGATGGCTCCCCCCTGGTGCCCACGCCCAATGTGCTCTGG
GACCTGGTTGACAGGATAGGCATCACTGTCCTGGTAACTGGGGCCAAGTGGCTGTCAGTG
CTGGAAGAGAAGGCCATGAAGCCGGTGGAAACCCACAGTCTCCAGATGCTCCACACGATC
CTGTCCACTGGCTCCCCACTGAAAGCCCAGAGCTACGAGTATGTCTACAGGTGCATCAAG
AGCAGCATCCTCCTGGGCTCCATCTCAGGAGGCACCGACATCATCTCCTGCTTCATGGGC
CACAATTTTTCTCTTCCTGTGTATAAAGGGGAGATTCAGGCCCGGAACCTGGGCATGGCC
GTGGAAGCGTGGAACGAGGAAGGAAAGGCGGTCTGGGGAGAGAGCGGCGAGCTGGTGTGT
ACTAAGCCGATCCCTTGCCAGCCCACACACTTCTGGAACGATGAGAACGGCAACAAGTAC
AGGAAGGCGTATTTCTCCAAATTCCCAGGTATCTGGGCTCATGGCGACTACTGCAGAATC
AACCCCAAGACCGGGGGCATCGTCATGCTTGGCCGGAGTGACGGCACCCTCAACCCCAAC
GGGGTGCGGTTCGGCAGCTCGGAAATCTATAACATTGTGGAATCCTTCGAGGAGGTGGAG
GACAGCCTGTGTGTCCCCCAGTATAACAAGTACAGGGAGGAGAGGGTGATCCTCTTCCTG
AAGATGGCCTCCGGGCACGCCTTCCAGCCTGACTTGGTTAAGAGGATCCGTGACGCCATC
CGCATGGGCTTGTCTGCGCGACACGTGCCCAGCCTCATCCTGGAAACCAAGGGCATCCCG
TATACGCTCAACGGCAAGAAAGTGGAAGTTGCCGTCAAACAGATCATCGCTGGAAAAGCC
GTGGAGCAAGGAGGTGCTTTCTCGAACCCCGAGACCCTGGATCTGTACCGGGACATCCCT
GAGCTGCAGGGCTTCTGA

# Metabolic_Enzyme_29_GenBank_ID_Gene:
AL833047

# Metabolic_Enzyme_29_Chromosome_Location:
Not Available

# Metabolic_Enzyme_29_Locus:
Not Available

# Metabolic_Enzyme_29_SNPs:
Not Available

# Metabolic_Enzyme_29_General_References:
Not Available

# Metabolic_Enzyme_29_References:
Not Available

# Metabolic_Enzyme_30_ID:
8794

# Metabolic_Enzyme_30_Name:
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3

# Metabolic_Enzyme_30_Synonyms:
Glucosaminyl N-deacetylase/N-sulfotransferase 3; NDST- 3; hNDST-3; N-heparan sulfate sulfotransferase 3; N-HSST 3[Includes: Heparan sulfate N-deacetylase 3

# Metabolic_Enzyme_30_Gene_Name:
NDST3

# Metabolic_Enzyme_30_Protein_Sequence:
>Bifunctional heparan sulfate Ndeacetylase/Nsulfotransferase 3
MSFIMKLHRHFQRTVILLATFCMVSIIISAYYLYSGYKQENELSETASEVDCGDLQHLPY
QLMEVKAMKLFDASRTDPTVLVFVESQYSSLGQDIIMILESSRFQYHIEIAPGKGDLPVL
IDKMKGKYILIIYENILKYINMDSWNRSLLDKYCVEYGVGVIGFHKTSEKSVQSFQLKGF
PFSIYGNLAVKDCCINPHSPLIRVTKSSKLEKGSLPGTDWTVFQINHSAYQPVIFAKVKT
PENLSPSISKGAFYATIIHDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLS
LDRYILVDIDDIFVGKEGTRMNTNDVKALLDTQNLLRAQITNFTFNLGFSGKFYHTGTEE
EDEGDDCLLGSVDEFWWFPHMWSHMQPHLFHNESSLVEQMILNKKFALEHGIPTDMGYAV
APHHSGVYPVHVQLYEAWKKVWNIKITSTEEYPHLKPARYRRGFIHKNIMVLPRQTCGLF
THTIFYKEYPGGPKELDKSIQGGELFFTVVLNPISIFMTHLSNYGNDRLGLYTFVNLANF
VKSWTNLRLQTLPPVQLAHKYFELFPDQKDPLWQNPCDDKRHRDIWSKEKTCDRLPKFLV
IGPQKTGTTALYLFLVMHPSILSNSPSPKTFEEVQFFNRNNYHRGIDWYMDFFPVPSNVT
TDFLFEKSANYFHSEEAPKRAASLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALKFS
FYEVISAGPRAPSELRALQKRCLVPGWYASHIERWLVYFPPFQLLIIDGQQLRTDPATVM
DEVQKFLGVLPHYNYSEALTFDSHKGFWCQLLEEGKTKCLGKSKGRKYPPMDSDSRTFLS
SYYRDHNVELSKLLHKLGQPLPSWLRQELQKVR

# Metabolic_Enzyme_30_Number_of_Residues:
873

# Metabolic_Enzyme_30_Molecular_Weight:
100903

# Metabolic_Enzyme_30_Theoretical_pI:
8.17

# Metabolic_Enzyme_30_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_30_General_Function:
Not Available

# Metabolic_Enzyme_30_Specific_Function:
Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity

# Metabolic_Enzyme_30_Pathway:
Not Available

# Metabolic_Enzyme_30_Reaction:
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine

# Metabolic_Enzyme_30_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_30_Signals:
1-30

# Metabolic_Enzyme_30_Transmembrane_Regions:
14-34

# Metabolic_Enzyme_30_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_30_EC_Link:
EC 2.8.2.8

# Metabolic_Enzyme_30_GenBank_ID_Protein:
4322247

# Metabolic_Enzyme_30_SwissProt_ID:
NDST3_HUMAN (O95803)

# Metabolic_Enzyme_30_swissprot_Name:
Not Available

# Metabolic_Enzyme_30_Genecard_id:
NDST3

# Metabolic_Enzyme_30_Geneatlas_id:
NDST3

# Metabolic_Enzyme_30_hgnc_id:
HGNC:7682

# Metabolic_Enzyme_30_PDB_ID:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_30_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_30_Gene_Sequence:
>2622 bp
ATGAGTTTTATCATGAAGCTTCACAGACACTTTCAAAGAACAGTCATTCTGCTTGCCACT
TTTTGTATGGTGAGCATTATCATTTCTGCTTACTACCTGTACAGTGGCTACAAACAGGAA
AATGAACTCTCTGAGACGGCTTCAGAAGTTGACTGTGGCGACCTCCAACACCTACCATAT
CAACTAATGGAAGTGAAAGCAATGAAGCTTTTTGATGCCTCAAGGACAGACCCCACAGTC
CTAGTATTTGTAGAGAGCCAGTACTCATCTCTTGGTCAAGACATCATTATGATTCTAGAA
TCAAGTAGATTCCAGTATCACATTGAAATTGCCCCTGGAAAGGGAGATCTCCCAGTGCTT
ATAGACAAAATGAAAGGCAAATACATTCTCATTATTTATGAGAATATTTTAAAGTATATA
AATATGGATTCCTGGAATCGAAGCCTTCTAGATAAATACTGTGTAGAATATGGTGTGGGT
GTCATTGGATTCCACAAAACTAGTGAGAAGAGTGTACAGAGCTTTCAGTTAAAAGGTTTC
CCTTTTTCCATATATGGAAATCTTGCAGTAAAAGATTGTTGTATTAATCCTCATTCTCCA
TTGATTCGTGTGACCAAATCTTCCAAGCTTGAAAAAGGTTCTTTACCTGGAACTGACTGG
ACAGTTTTTCAGATTAATCATTCAGCCTATCAACCAGTAATATTTGCCAAAGTAAAGACC
CCAGAAAACCTTTCTCCTTCCATCTCTAAAGGTGCTTTTTATGCCACTATTATACATGAC
CTGGGGCTTCATGATGGAATTCAAAGGGTTCTTTTTGGCAACAACTTGAACTTTTGGCTG
CACAAGCTCATCTTCATAGATGCCATCTCCTTCTTATCAGGGAAGAGGCTGACATTGTCC
TTGGACAGGTACATTCTTGTGGATATTGATGATATATTTGTGGGAAAAGAGGGAACAAGA
ATGAACACCAATGATGTAAAGGCCCTGCTTGATACTCAGAATCTTTTGCGTGCACAAATC
ACAAATTTTACATTCAACCTGGGATTTTCAGGGAAATTTTACCATACAGGAACTGAAGAG
GAAGATGAAGGAGATGACTGTCTGTTGGGGTCTGTGGATGAGTTCTGGTGGTTTCCTCAC
ATGTGGAGCCATATGCAGCCCCACCTCTTCCACAATGAGTCATCTTTGGTGGAGCAGATG
ATTCTCAACAAAAAATTTGCCTTAGAGCACGGCATTCCAACGGACATGGGCTACGCTGTG
GCCCCTCACCATTCGGGCGTCTACCCTGTACATGTTCAGCTTTATGAGGCCTGGAAGAAG
GTCTGGAATATTAAAATCACCAGCACTGAAGAATATCCACATCTGAAGCCAGCTAGATAC
CGGAGGGGTTTTATCCACAAAAACATCATGGTTCTCCCAAGACAAACCTGTGGGCTTTTC
ACTCACACCATTTTCTACAAAGAATATCCAGGGGGTCCTAAAGAGCTGGATAAGAGTATC
CAAGGAGGAGAACTTTTCTTCACTGTCGTCCTCAACCCTATCAGCATTTTCATGACCCAT
TTGTCCAACTATGGGAATGACCGACTGGGATTATATACATTTGTTAATCTGGCCAACTTT
GTGAAGAGCTGGACCAACCTGCGACTTCAGACTCTGCCTCCAGTACAACTGGCCCACAAG
TATTTTGAGCTGTTTCCTGATCAGAAAGACCCTCTCTGGCAGAATCCTTGCGATGACAAA
CGCCACAGAGACATTTGGTCTAAAGAAAAAACTTGTGATCGCTTACCAAAATTCTTGGTA
ATAGGACCCCAGAAAACTGGTACCACTGCTTTGTATTTGTTCCTGGTTATGCATCCTTCC
ATCCTTAGTAACTCCCCCAGCCCAAAAACCTTTGAGGAGGTACAGTTCTTTAATAGAAAT
AACTACCACAGGGGGATTGATTGGTATATGGATTTCTTCCCAGTCCCATCTAATGTCACT
ACCGACTTTTTGTTTGAGAAGAGTGCCAATTACTTCCACTCAGAGGAAGCCCCTAAAAGA
GCTGCTTCTCTGGTTCCCAAAGCCAAGATTATCACCATTCTCATTGACCCTTCAGACCGA
GCATACTCCTGGTACCAGCATCAGCGATCACATGAAGACCCTGCAGCTCTGAAGTTTAGC
TTCTACGAAGTGATCTCAGCAGGGCCCCGTGCACCCTCGGAGCTCAGAGCCTTGCAGAAG
AGATGTTTGGTCCCGGGGTGGTATGCCAGCCACATCGAGAGATGGCTTGTTTATTTCCCC
CCATTTCAGTTGCTAATTATTGATGGGCAACAACTAAGAACTGATCCTGCTACAGTGATG
GATGAAGTACAGAAGTTTCTAGGAGTCTTGCCTCATTATAATTACTCAGAAGCTTTAACG
TTTGATTCTCATAAAGGTTTCTGGTGTCAGTTACTGGAAGAAGGTAAAACAAAATGCCTT
GGAAAGAGCAAAGGAAGAAAATACCCTCCAATGGATTCTGATAGCAGGACATTTCTGTCA
AGCTACTATCGAGATCACAACGTGGAACTCTCAAAGCTGCTGCACAAACTGGGTCAGCCT
CTGCCATCCTGGCTGAGACAGGAGCTGCAGAAAGTAAGATAG

# Metabolic_Enzyme_30_GenBank_ID_Gene:
AF074924

# Metabolic_Enzyme_30_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_30_Locus:
4q26

# Metabolic_Enzyme_30_SNPs:
rs617430; rs10028980; rs17049697; rs11934022; rs10012897; rs13138385; rs13152576; rs6534079; rs10857057; rs7657704; rs7656160; rs11098420; rs2389498; rs13149783; rs9999038; rs11737538; rs4328979; rs2389497; rs12500561; rs7683628; rs13125367; rs10029850; rs11734982; rs7683496; rs4569815; rs13149429; rs11731535; rs2389523; rs2892790; rs586224; rs2389527; rs2389519; rs615837; rs2389516; rs2204269; rs2389526; rs2389517; rs2030633; rs2030634; rs611659; rs11730541; rs4834672; rs2892800; rs633398; rs4834667; rs12711064; rs2389503; rs2389518; rs10026541; rs11931079; rs9999336; rs1829910; rs13134901; rs4240314; rs1589718; rs6855052; rs4834668; rs11098425; rs4616829; rs10028823; rs10018844; rs7669618; rs4833564; rs11947244; rs4428355; rs6534082; rs650460; rs11944227; rs2389520; rs1523748; rs6853879; rs6851494; rs678177; rs1996725; rs2389501; rs12642204; rs7689231; rs2389510; rs4327555; rs12506091; rs4240320; rs2389500; rs13435006; rs1872771; rs4833560; rs2389521; rs7655439; rs1589719; rs7664383; rs7655519; rs11933280; rs2389502; rs640713; rs6822996; rs10022145; rs6842491; rs788662; rs13119835; rs2389524; rs10030249; rs631271; rs11736688; rs6824418; rs6534084; rs3107483; rs1949760; rs7685455; rs1829911; rs11098424; rs4833561; rs11945921; rs17049695; rs2389512; rs586073; rs10028343; rs11933537; rs4834661; rs6842524; rs10008049; rs13127321; rs10014096; rs6816778; rs12506555; rs11940107; rs1403846; rs11934128; rs11098421; rs6823328; rs4240315; rs17049650; rs613083; rs6857232; rs788664; rs7661325; rs10020944; rs7654521; rs12508017; rs9685965; rs2389509; rs3817274; rs17593877; rs11947911; rs613443; rs17049656; rs4240319; rs687492; rs6820851; rs10023656; rs13104251; rs11727684; rs11727817; rs2892788; rs7654652; rs7689157; rs11945777; rs1319938; rs6857041; rs625546; rs6823295; rs4833563; rs11098422; rs11945329; rs17593919; rs4240318; rs10014957; rs2892799; rs11945958; rs17626497; rs2389515; rs2271577; rs607961; rs10015485; rs9992827; rs17594018; rs7671173; rs7688063; rs17049622; rs11098426; rs4240313; rs6534088; rs11946755; rs6820367; rs7687849; rs13123722; rs7435331; rs11946833; rs13114895; rs17049699; rs11098429; rs10019969; rs13142184; rs11940880; rs11726746; rs13123277; rs4318721; rs9995675; rs6818042; rs17049694; rs11947630; rs11945882; rs11944236; rs10012359; rs4558930; rs4834665; rs13114867; rs615517; rs17692850; rs11930405; rs7439663; rs2892791; rs6842393; rs6855536; rs11933599; rs7688443; rs11931769; rs6856076; rs13114621; rs6848301; rs11731179; rs10213280; rs4571408; rs11943650; rs10518291; rs10002634; rs11098430; rs6842651; rs17593793; rs2389567; rs4240316; rs2389506; rs11947605; rs6534089; rs2389508; rs4452509; rs609512; rs11098428; rs1403845; rs2271578; rs7679658; rs10033308; rs9637622; rs10021781; rs17049690; rs618177; rs17049700; rs10007553; rs10033678; rs788663; rs13139875; rs11727421; rs7695706; rs11730687; rs11728941; rs4834660; rs4147038; rs11947552; rs10015232; rs2049362; rs10020473; rs11934183; rs1916686; rs6842507; rs6822408; rs7671515; rs9996753; rs11930876; rs6842558; rs10024548; rs6820108; rs7671434; rs11942974; rs10001247; rs10004607; rs11937777; rs10440400; rs2140475; rs597881; rs6835860; rs11098427; rs11722698; rs11944865; rs13111697; rs581739; rs11934324; rs6837896; rs7678461; rs10016011; rs11945026; rs4834656; rs10025029; rs11946772; rs660905; rs6842719; rs11730611; rs11722962; rs9992747; rs3749506; rs17049570; rs6835510; rs17049627; rs6842372; rs11941660; rs6823125; rs11932087; rs7677274; rs2389513; rs6820061; rs4546313; rs17049706; rs17049693; rs10024459; rs6842557; rs13434652; rs10018706; rs10030269; rs2389504; rs593966; rs10008013; rs11931778; rs17594243; rs6813615; rs17049630; rs10016301; rs9790637; rs4397073; rs11935069; rs17049609; rs12641173; rs6825105; rs7671359; rs11940076; rs17049676; rs11942654; rs11723877; rs17515832; rs12374268; rs7671562; rs6848037; rs10023699; rs6852565; rs2892789; rs13104129; rs2892785; rs11931869; rs4834670; rs10023964; rs9996762; rs13138982; rs11931409; rs1523746; rs9637623; rs11930782; rs4833565; rs11937205; rs10001926; rs13434825; rs17049626; rs10001520; rs2389505; rs1608506; rs10016206; rs4576085; rs7687505; rs10016285; rs7699653; rs1523747; rs2389507; rs9998981; rs662581; rs11945537; rs2389514; rs7688806; rs631623; rs4131600; rs10033918; rs9684393; rs13130953; rs4147036; rs11098423; rs10031402; rs11938502; rs662086; rs9991787; rs4240317; rs6852469; rs7671232; rs10012196; rs10012051; rs2892786; rs4833566; rs10024837; rs2308027; rs4280816; rs17049625; rs17626479; rs13149888; rs17594054; rs12504529; rs10025690; rs7684275; rs16997442; rs11941062; rs17049648; rs7681830; rs10004592; rs17049698; rs17594257; rs10014055; rs9998199; rs7670397; rs6842689; rs4834673; rs10021970; rs12640268; rs13135646; rs11733562; rs13140433; rs11932297; rs13151098; rs4569819; rs10033927; rs13126882; rs12501122; rs13141841; rs7661522; rs17626520; rs2389525; rs17049588; rs4834666; rs11943088; rs1994384; rs11728724; rs2389522; rs11726838; rs11733528; rs641962; rs11939817; rs7685325; rs6534078; rs6534077; rs7671497; rs35086179; rs35147253; rs10011715; rs13118131; rs12648773; rs7436139; rs35238894; rs12648006; rs13110631; rs34916324; rs10006024; rs34883631; rs13134931; rs13144249; rs2892784; rs35050001; rs34646125; rs13110642; rs12502898; rs2389496; rs28812911; rs13134916; rs2389495; rs35267341; rs10020284; rs33930999; rs28729926; rs34730378; rs13119849; rs7683791; rs2389499; rs35245189; rs12501652; rs4001572; rs13110657; rs13123909; rs13133776; rs35257604; rs7662255; rs34893788; rs12501383; rs28648504; rs34795498; rs7436325; rs35359278; rs5861377; rs7435948; rs34835262; rs12498683; rs1608505; rs35263017; rs3080149; rs28847022; rs36035970; rs34812479; rs34623333; rs3830507; rs34564513; rs6853684; rs4833567; rs12505156; rs13131380; rs36227842; rs35826097; rs35938936; rs17049649; rs34302716; rs10027013; rs10607535; rs35776915; rs28848859; rs33922704; rs34143377; rs28715892; rs35580866; rs9991087; rs1523744; rs10702072; rs5861375; rs28697099; rs2892787; rs35491780; rs35821057; rs13121129; rs7666861; rs35683434; rs11335648; rs35034865; rs36208859; rs35573813; rs28562324; rs35216924; rs13149170; rs10628437; rs28734874; rs4833562; rs13134451; rs34452190; rs28781349; rs4566725; rs13134833; rs33985434; rs28669076; rs34924654; rs10633685; rs10002892; rs11416507; rs11722023; rs2271579; rs11448394; rs35054481; rs1343827; rs13131971; rs28706008; rs35094555; rs35218485; rs41278065; rs35704864; rs4834664; rs673682; rs17515651; rs12505418; rs28851582; rs34872510; rs35237651; rs36207620; rs28667401; rs13137083; rs4400066; rs36127253; rs28886020; rs11728964; rs35139409; rs34756619; rs1523749; rs35995808; rs35073718; rs34315750; rs11439726; rs12331617; rs676802; rs35375764; rs36006756; rs34255267; rs28789108; rs34909956; rs28500762; rs4546315; rs5742375; rs13127368; rs11298940; rs28723489; rs10004800; rs35754873; rs5861383; rs35715840; rs4147039; rs28847597; rs11384076; rs28576396; rs7356311; rs17515561; rs34008240; rs36117603; rs11281529; rs10003652; rs5861378; rs5861380; rs35988831; rs35960010; rs35910994; rs788661; rs13131623; rs11297151; rs28567841; rs13132331; rs9968544; rs28631338; rs34054720; rs4404621; rs34242038; rs10033412; rs34918708; rs35648060; rs6828552; rs35502256; rs28771156; rs34872625; rs28683619; rs35946502; rs34418586; rs35051708; rs35138500; rs11737224; rs5861376; rs6824718; rs28819697; rs13123381; rs11737229; rs33994401; rs34285969; rs34185290; rs34558995; rs34655188; rs34872487; rs35694467; rs34764099; rs28507199; rs9996857; rs35017662; rs28711393; rs28646146; rs28555974; rs6856765; rs11724386; rs35872631; rs11299569; rs4502754; rs28634983; rs5861382; rs35792741; rs34595271; rs34626006; rs11947071; rs35099667; rs36070709; rs13113258; rs10633686; rs28484271; rs10007959; rs17593863; rs13114249; rs35851865; rs35051152; rs28665669; rs11322429; rs28856120; rs28740899; rs34290697; rs28665169; rs28393351; rs33984401; rs35661296; rs35210682; rs28885399; rs11298939; rs34475822; rs4834657; rs33972233; rs9307452; rs28619162; rs34213306; rs10568846; rs28558085; rs10030449; rs13135500; rs35844977; rs10027893; rs4557347; rs28434240; rs35754081; rs34345840; rs35475347; rs28728238; rs6847359; rs34826732; rs33931637; rs33936644; rs10014402; rs11336961; rs10007381; rs35591587; rs28682376; rs34714560; rs34711397; rs34563259; rs28766305; rs12505582; rs11728950; rs12108668; rs10656718; rs28396926; rs28479964; rs28507472; rs35554727; rs28889086; rs10021128; rs35235550; rs35018183; rs34017200; rs11419568; rs11347319; rs11294350; rs28688245; rs4362895; rs4834658; rs35307549; rs7654695; rs10005348; rs34004725; rs34405308; rs28753894; rs10025515; rs35983699; rs28600918; rs33977562; rs10007918; rs34646523; rs10031257; rs35067389; rs4502667; rs35641856; rs28776305; rs41278063; rs28826087; rs35524586; rs10440401; rs34190534; rs28524963; rs28536042; rs28711185; rs36098020; rs34994076; rs28421577; rs35749089; rs36218730; rs13106276; rs28396217; rs34419266; rs33966390; rs10669730; rs36119137; rs28631152; rs28668316; rs7661076; rs34171033; rs35652422; rs28690846; rs28708693; rs36139871; rs13120016; rs35492744; rs34730310; rs10024910; rs34835669; rs7439873; rs34182759; rs666558; rs10681234; rs13132346; rs34872062; rs36219518; rs35381491; rs34782963; rs5861379; rs36229372; rs34176697; rs35789417; rs12511554; rs28589481; rs10025979; rs28498433; rs11380294; rs10027703; rs35876590; rs5861381; rs10535482; rs13125461; rs28667022; rs34850426; rs10005512; rs28515963; rs28768382; rs34238547; rs10030057; rs4437319; rs34834977; rs35294396; rs7665014; rs10004528; rs35238803; rs36053074; rs11729027; rs35816742; rs35254931; rs35528360; rs36214652; rs34466659; rs10050326; rs10014154; rs13136897; rs34463969; rs35137516; rs28399774; rs35650624; rs35112049; rs34804902; rs33926182; rs33979318; rs28603319; rs3838634; rs34835050; rs35641809; rs28378646; rs35077679; rs34248952; rs34101813; rs35192544; rs28687476; rs11408271; rs33927682; rs34723948; rs10006223; rs34660107; rs13109564; rs4519863; rs28374287; rs10011099; rs2389511; rs6845921; rs13129847; rs34639699; rs644797; rs1523745; rs10569298; rs10023858; rs35188223; rs2389566; rs13103629; rs35250714; rs35647802; rs36081446; rs28508556; rs28627299; rs34891564; rs36092065; rs12505642; rs35621837; rs35982667; rs13113193; rs10025340; rs28430981; rs28375657; rs4544776; rs34091625; rs35433749; rs28823876; rs35284850; rs13109168; rs35204114; rs10005659; rs10024765; rs34165051; rs34224588; rs7686670; rs613149; rs33953463; rs34004705; rs34525909; rs35754899; rs12499751; rs28630407; rs6848598; rs4147040; rs35472465; rs10213202; rs13125397; rs33923588; rs10613667; rs35760279; rs33971782; rs34293412; rs28882407; rs35553303; rs11396935; rs17049590; rs9993556; rs6148636; rs28369617; rs33928766; rs28667620; rs10682796; rs34548920; rs34644680; rs34915366; rs34436506; rs11934512; rs28656282; rs28625833; rs28478577; rs4526047; rs35943639; rs35276919; rs10000049; rs11727769; rs11935016; rs11946941; rs12509230; rs1318459; rs1319061; rs17594447; rs2138009; rs2254204; rs2254215; rs2254218; rs2291416; rs2389491; rs2389492; rs2389493; rs3134; rs34514948; rs35612621; rs4438821; rs4479780; rs4577651; rs582448; rs608228; rs6534074; rs656079; rs7687673; rs7688055

# Metabolic_Enzyme_30_General_References:
9915799; 12975309

# Metabolic_Enzyme_30_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7551

# Macromolecular_Interacting_Partner_1_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_1_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_1_Locus:
6p21.3

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_1_References:
16888030; 16888805; 16912650

# Macromolecular_Interacting_Partner_2_ID:
8490

# Macromolecular_Interacting_Partner_2_Name:
ACOT12 protein

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
ACOT12

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>ACOT12 protein
MERPAPGEVVMSQAIQPAHATARGELSAGQLLKWIDTTACLAAEKHAGVSCVTASVDDIQ
FEETARVGQVITIKAKVTRAFSTSMEISIKVMVQDMLTGIEKLVSVAFSTFVAKPVGKEK
IHLKPVTLLTEQDHVEHNLAAERRKVRLQHEDTFNNLMKESSKFDGQ

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
167

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
18327

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
7.15

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  catalytic activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Lipid transport and metabolism

# Macromolecular_Interacting_Partner_2_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF03061:4HBT

# Macromolecular_Interacting_Partner_2_Signals:
Not Available

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
58477543

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
Q5FWE9_HUMAN (Q5FWE9)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
ACOT12

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
ACOT12

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:24436

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>504 bp
ATGGAGCGGCCGGCGCCCGGCGAGGTGGTCATGAGCCAAGCCATCCAGCCGGCGCACGCC
ACTGCGCGCGGCGAGCTGAGCGCGGGGCAGCTGCTCAAGTGGATCGACACCACCGCCTGC
CTGGCGGCTGAGAAACATGCTGGAGTTTCCTGCGTTACAGCCTCAGTGGATGACATACAG
TTTGAGGAGACAGCTAGAGTTGGACAAGTTATAACCATCAAAGCAAAAGTTACTAGAGCA
TTCAGCACAAGCATGGAGATCAGTATCAAGGTCATGGTACAGGATATGCTCACTGGCATT
GAGAAGCTTGTTAGTGTGGCTTTCTCCACATTTGTAGCCAAACCAGTTGGAAAAGAAAAG
ATTCATTTAAAACCAGTCACACTTCTAACTGAACAAGATCATGTGGAACATAATCTGGCT
GCTGAGAGAAGGAAAGTTCGATTACAACATGAAGATACCTTTAACAATTTAATGAAGGAA
AGTAGCAAATTTGATGGTCAGTAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
BC089437

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_2_Locus:
5q14.1

# Macromolecular_Interacting_Partner_2_SNPs:
rs10371; rs34607174; rs6452403; rs4703517; rs11745197; rs4235653; rs7717804; rs7733558; rs4703520; rs11957050; rs6881927; rs1896775; rs7702227; rs6452399; rs7734127; rs6872459; rs7727053; rs6452406; rs10039986; rs6452402; rs4704723; rs11749621; rs4703516; rs10078088; rs7728156; rs7716302; rs4277893; rs10942262; rs6452401; rs7714558; rs6885431; rs10053334; rs4703518; rs6452405; rs6452400; rs11742598; rs3857368; rs10042996; rs6882140; rs12514594; rs7729671; rs13357760; rs6871569; rs6881492; rs11954685; rs11740623; rs4703834; rs6872684; rs7703082; rs17230425; rs7713774; rs4703835; rs6860593; rs6886158; rs6881271; rs4703836; rs4704722; rs7446307; rs11955415; rs13174473; rs10035223; rs10942261; rs12517108; rs13155682; rs11747702; rs11950107; rs10038566; rs13169852; rs11950658; rs13163821; rs12520468; rs6890955; rs12523386; rs11960480; rs12517153; rs13186206; rs6881812; rs7706593; rs10040901; rs9688138; rs6873953; rs10057287; rs6881478; rs12519060; rs7719033; rs4703519; rs11741065; rs12108697; rs13154060; rs6859712; rs7736224; rs13154467; rs10078484; rs7726536; rs7735423; rs11750649; rs7735449; rs13357762; rs9686517; rs7718935; rs7706867; rs2059894; rs6890483; rs2162974; rs11953727; rs13171460; rs11954484; rs9686399; rs12697702; rs9546; rs1366597; rs35316986; rs13178695; rs34577490; rs9885322; rs35612570; rs6872090; rs28714197; rs6873688; rs6881957; rs13181700; rs35550583; rs10617260; rs34743880; rs34766269; rs35219024; rs11313535; rs34955738; rs9885510; rs34729119; rs11741735; rs7720907; rs35132583; rs34443861; rs34138509; rs9885325; rs36123812; rs35339139; rs34126274; rs10058787; rs34394766; rs13181989; rs13157817; rs35452641; rs13176170; rs35476333; rs11343919; rs35917298; rs34385090; rs13186560; rs35627535; rs6879397; rs7446383; rs35604690; rs6890957; rs35626276; rs3052892; rs6874204; rs35315461; rs10533341; rs35810370; rs13186689; rs35863495; rs11443702; rs34070636; rs7717621; rs34905257; rs11271359; rs35532389; rs36052619; rs35399330; rs13170632; rs28874676; rs34235173; rs34804859; rs13157241; rs34764200; rs33997120; rs10058788; rs13155027; rs11343063; rs13170970; rs34892080; rs11739092; rs10058800; rs34623194; rs13355076; rs13181953; rs36197694; rs34921781; rs34307954; rs4133039; rs11291371; rs13181707; rs35675731; rs13185752; rs10037433; rs13154229; rs34714548; rs7737568; rs34817412; rs4704721; rs34896188; rs34513795; rs34115148; rs35399912; rs28515696; rs10626819; rs34655510; rs3052908; rs11385870; rs35003041; rs34760824; rs34588330; rs10626203; rs33957145; rs34521130; rs10053706; rs10056565; rs10063615; rs10076567; rs12188470; rs12519433; rs13190050; rs13190332; rs1366598; rs16878614; rs2042980; rs2059892; rs33989062; rs34094852; rs35367896; rs4502795; rs4703521; rs4703522; rs4703523; rs6868743; rs6875430; rs6889795; rs723045; rs723046; rs7734902

# Macromolecular_Interacting_Partner_2_General_References:
12477932

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8605

# Macromolecular_Interacting_Partner_3_Name:
Citrate lyase beta like

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
CLYBL

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Citrate lyase beta like
LQAIDLVYIDFRDGAGLLRQSREGAAMGFTGKQVIHPNQIAVVQEQFSPSPEKIKWAEEL
IAAFKEHQQLGKGAFTFQGSMIDMPLLKQAQNTVTLATSIKEK

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
103

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
11401

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
7.70

# Macromolecular_Interacting_Partner_3_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_3_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF03328:HpcH_HpaI

# Macromolecular_Interacting_Partner_3_Signals:
Not Available

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
57160623

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
Q5JVC0_HUMAN (Q5JVC0)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
CLYBL

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
CLYBL

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:18355

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>961 bp
GAAAGCGTCTCTAGCAGCTGATATCCCCAGACTTGGATATAGTTCCTCATCCCATCACAA
GTACATCCCCCGGAGGGCAGTGCTTTATGTACCTGGAAATGATGAAAAGAAAATAAAGAA
GATTCCATCCCTGAATGTAGATTGTGCAGTGCTCGACTGTGAGGATGGAGTGGCTGCAAA
CAAAAAGAATGAAGCTCGACTGAGAATTGTAAAAACTCTTGAAGACATTGATCTGGGCCC
TACTGAAAAATGTGTGAGAGTCAACTCAGTTTCCAGTGGTCTGGCGGAAGAAGACCTAGA
GACCCTTTTGCAATCCCGGGTCCTTCCTTCCAGCCTGATGCTACCAAAGGTGGAAAGTCC
TGAAGAAATCCAGTGGTTTGCAGACAAATTTTCATTCCACTTAAAAGGCCGAAAACTTGA
ACAACCAATGAATTTAATCCCTTTTGTGGAAACTGCAATGGGTTTGCTCAATTTTAAGGC
AGTGTGTGAAGAAACCCTGAAGGTCGGGCCTCAAGTAGGTCTCTTTCTAGATGCAGTCGT
TTTTGGAGGAGAAGACTTTCGAGCCAGCATAGGTGCAACAAGTAGTAAAGAAACCCTGGA
TATTCTCTACGCCCGGCAAAAGATTGTTGTCATAGCGAAAGCCTTTGGTCTCCAAGCCAT
AGATCTGGTGTACATTGACTTTCGAGATGGAGCTGGGCTGCTTAGACAGTCACGAGAAGG
AGCCGCCATGGGCTTCACTGGTAAGCAGGTGATTCACCCTAACCAAATTGCCGTGGTCCA
GGAGCAGTTTTCTCCTTCCCCTGAAAAAATTAAGTGGGCTGAAGAACTGATTGCTGCCTT
TAAAGAACATCAACAATTAGGAAAGGGGGCCTTTACTTTCCAAGGGAGTATGATCGACAT
GCCATTACTGAAGCAGGCCCAGAACACTGTTACGCTTGCCACCTCCATCAAGGAAAAATG
A

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AL137139

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:13

# Macromolecular_Interacting_Partner_3_Locus:
13q32

# Macromolecular_Interacting_Partner_3_SNPs:
rs3783185; rs17577293; rs35680839; rs1924104; rs11617041; rs2281757; rs8002438; rs7997714; rs12019809; rs9300573; rs2281756; rs12584825; rs1886033; rs9513680; rs7333559; rs9557330; rs6491538; rs2296117; rs7992643; rs7318415; rs7998712; rs7331251; rs11616403; rs12323012; rs6491539; rs9582352; rs1040997; rs9554647; rs7318038; rs12018767; rs7317993; rs2281755; rs7992592; rs9517908; rs9554648; rs9585264; rs6491536; rs2038695; rs9585263; rs11842450; rs9557333; rs1924105; rs6491537; rs7322872; rs7994827; rs2763950; rs725834; rs2039933; rs2793762; rs2763947; rs2761153; rs2057490; rs912284; rs1886031; rs1886035; rs2793760; rs912288; rs2763948; rs2038693; rs968535; rs2057489; rs912290; rs2390323; rs2761174; rs1028710; rs2806280; rs2806285; rs1000022; rs2793745; rs1886034; rs6491526; rs9554619; rs754003; rs2806295; rs9300571; rs2806281; rs912285; rs9585198; rs2806284; rs12866973; rs12184508; rs9557276; rs11838894; rs7328481; rs9554641; rs2761156; rs9517818; rs2793761; rs2761169; rs9557286; rs912289; rs1105576; rs9554620; rs6491534; rs7993372; rs2793749; rs12430063; rs4772245; rs2806290; rs7333752; rs7336903; rs3742254; rs8002555; rs4772238; rs2806283; rs9517847; rs1924099; rs2761163; rs2763940; rs754004; rs10775026; rs7984263; rs7994744; rs11069375; rs4592516; rs2761173; rs2793746; rs9585195; rs7986079; rs7982561; rs10508039; rs9557284; rs4771344; rs9513673; rs7989959; rs4772246; rs8002475; rs9517906; rs9513648; rs7982186; rs7327267; rs7326626; rs7333425; rs11069379; rs7334942; rs2390357; rs1022845; rs4772225; rs9585171; rs2038694; rs2806300; rs4772239; rs9517898; rs7981650; rs878418; rs912283; rs9557318; rs7334071; rs2761152; rs2298066; rs9517825; rs12427607; rs4511391; rs7338186; rs9513660; rs9585157; rs1107450; rs2153672; rs2806279; rs9557311; rs7336899; rs2806297; rs2390354; rs7331804; rs9554625; rs2761158; rs7991703; rs2761165; rs7327909; rs7996352; rs7999726; rs7995737; rs9300564; rs2761171; rs2761155; rs9554617; rs9517863; rs9300569; rs9585250; rs4340181; rs4772229; rs7323117; rs4525350; rs7317032; rs7984112; rs927596; rs7996792; rs9554636; rs2793748; rs9300565; rs9513675; rs6491521; rs17473570; rs9582350; rs16956874; rs6491531; rs4418926; rs7328417; rs7333886; rs9554624; rs12100265; rs17612226; rs9513658; rs9585169; rs2761154; rs7992587; rs2793758; rs17576658; rs7319374; rs2793787; rs12430038; rs10508040; rs9557309; rs7317678; rs17612198; rs7994564; rs8002591; rs9554618; rs7335639; rs11069374; rs4771343; rs12873858; rs4772240; rs9517814; rs17577167; rs9557290; rs9557321; rs7316944; rs9513664; rs12856441; rs9554639; rs2057488; rs7337354; rs2806278; rs2806307; rs1341399; rs12584570; rs8001493; rs4267173; rs6491525; rs9582351; rs2893010; rs9585252; rs9585161; rs2793769; rs9517885; rs7321513; rs6491532; rs9513653; rs7328387; rs9634449; rs2806298; rs7330733; rs4772222; rs721922; rs17612087; rs9554642; rs9517877; rs4334138; rs12584833; rs7326777; rs9557319; rs9300567; rs12431270; rs4771342; rs12877095; rs9557317; rs7330589; rs9517829; rs2806306; rs9517895; rs9557297; rs8000862; rs9557298; rs11620246; rs7328242; rs7995431; rs9513665; rs9517905; rs1924107; rs2806310; rs17612107; rs11616808; rs2806275; rs9585243; rs7335739; rs9554637; rs11840104; rs9557325; rs7994234; rs17657985; rs1555589; rs7323189; rs9513667; rs7991377; rs9585162; rs912659; rs9513672; rs9585211; rs9517869; rs7994919; rs11839315; rs2761167; rs1107382; rs4483710; rs9557308; rs7335678; rs10083230; rs12868139; rs2806302; rs9585226; rs11839716; rs2806309; rs9554634; rs4564437; rs9517871; rs9300570; rs7981201; rs2806286; rs12427494; rs9300561; rs12868090; rs9582329; rs11840327; rs7328023; rs4384480; rs4772236; rs912287; rs8000571; rs7326772; rs7998536; rs11839651; rs7323953; rs9517892; rs2761168; rs9517889; rs2057487; rs10083271; rs7332098; rs9517899; rs1125436; rs7319987; rs2282401; rs7139930; rs12430048; rs9513647; rs9585242; rs2250311; rs7330630; rs1886030; rs11842056; rs2793763; rs7319505; rs4772249; rs9557282; rs11839563; rs4771340; rs4290347; rs9554633; rs9585178; rs1028711; rs9517893; rs11069372; rs7139402; rs9513661; rs7999987; rs9513663; rs8000435; rs9517830; rs9557293; rs2806292; rs9585234; rs7994852; rs9554645; rs6491523; rs9585231; rs2793741; rs16956730; rs7987714; rs9670678; rs7995755; rs9517886; rs9517813; rs16956921; rs2181608; rs2793751; rs11839875; rs17576929; rs9585245; rs2182037; rs12875247; rs7324176; rs2390355; rs1987492; rs9582336; rs9517817; rs6491533; rs2761162; rs7986248; rs9300568; rs4772227; rs11839443; rs9517864; rs9634517; rs34667146; rs4772241; rs9517891; rs7318060; rs9513654; rs2806303; rs9517901; rs16956916; rs12429300; rs9513674; rs7332426; rs16956961; rs2390359; rs2761157; rs4377025; rs7995280; rs7993002; rs1028712; rs11616546; rs16956764; rs7988259; rs10851107; rs9585164; rs7985592; rs9585175; rs12877564; rs9517878; rs9557268; rs9585233; rs11069382; rs17658053; rs9585248; rs11839991; rs9585208; rs2763939; rs7326142; rs9513650; rs7319992; rs7333543; rs7985956; rs9670010; rs2763943; rs7987600; rs2793785; rs7984587; rs9517808; rs11069381; rs12869989; rs7338007; rs7998807; rs12866699; rs2763944; rs9517824; rs2000148; rs9557267; rs7983983; rs7993694; rs4411369; rs12018070; rs2181607; rs16957038; rs9582347; rs7986437; rs1111867; rs9300572; rs9517861; rs10454027; rs2027442; rs4439619; rs12585089; rs9513649; rs4505173; rs4772224; rs9300562; rs1544189; rs11616786; rs9517835; rs9585153; rs4772233; rs7317837; rs12184851; rs11843986; rs1555590; rs2793786; rs9557273; rs9554644; rs9517831; rs9557291; rs3831038; rs7989523; rs7988767; rs6491535; rs17611399; rs7329724; rs2793784; rs9557272; rs12427504; rs11840934; rs9557320; rs7982629; rs11842082; rs2761166; rs9517867; rs9517887; rs9585200; rs6491528; rs2793764; rs9582348; rs1125435; rs2761159; rs9554631; rs9585216; rs2390302; rs7335229; rs11619446; rs10851109; rs7987145; rs9517860; rs7318411; rs9513656; rs9557306; rs16957003; rs4772237; rs1924100; rs9517820; rs2806277; rs9585207; rs2806301; rs2806305; rs9585173; rs2761164; rs9585185; rs11842371; rs2763949; rs7986083; rs9582344; rs7490120; rs7981731; rs7321720; rs9517904; rs9557288; rs8002734; rs4771341; rs9554616; rs9517884; rs9517872; rs7317914; rs4288858; rs11840555; rs3033552; rs9517862; rs16956964; rs2806288; rs4772247; rs2236583; rs9557301; rs2763945; rs11841969; rs16956883; rs16957012; rs9517832; rs9513644; rs9557316; rs7320176; rs12429794; rs1924108; rs9557307; rs12584897; rs9517821; rs7995103; rs10454527; rs17473598; rs9517876; rs9517811; rs4360797; rs9517816; rs2761175; rs4771347; rs9585166; rs16956821; rs7986249; rs9582335; rs7319880; rs958764; rs9557304; rs9582345; rs12427647; rs10220173; rs9517897; rs17611302; rs2806293; rs8000012; rs9585186; rs9557271; rs2763938; rs9517837; rs9585244; rs9585172; rs11841056; rs7998088; rs1924110; rs9557323; rs9517827; rs9554646; rs2806304; rs9742582; rs2793754; rs9585206; rs17577153; rs2761161; rs912286; rs2390356; rs2806296; rs8000609; rs16956828; rs2793742; rs9513671; rs6491527; rs16956889; rs9557287; rs17657201; rs7995312; rs2806308; rs4424774; rs2761172; rs9557310; rs4400905; rs11843710; rs9557302; rs7328196; rs999631; rs2761170; rs4772235; rs7985416; rs7337811; rs2763946; rs7319139; rs11619680; rs11840467; rs7325119; rs9582331; rs1924109; rs9557269; rs12429830; rs13378481; rs9300557; rs9582338; rs7328521; rs869323; rs2763934; rs1886032; rs11616689; rs9582328; rs41281112; rs12873611; rs34411915; rs35611394; rs34078213; rs3742255; rs12873851; rs9585262; rs34625836; rs28642354; rs35177836; rs12869625; rs7995068; rs7986754; rs12017062; rs35024669; rs9585266; rs35061922; rs35546044; rs28698863; rs35358394; rs12018768; rs1924106; rs34875340; rs2209086; rs35968589; rs9585257; rs12874770; rs9585261; rs9517909; rs28660130; rs34773665; rs34896012; rs9585272; rs7992743; rs9517911; rs9557334; rs10707455; rs9557329; rs9585269; rs9585265; rs7327776; rs34366931; rs9585258; rs9582353; rs10635703; rs12017613; rs2209087; rs10598307; rs9585260; rs9517912; rs9557332; rs9585271; rs35025545; rs11435009; rs12872031; rs12561106; rs12873057; rs28592795; rs9585273; rs9557328; rs34151390; rs9585256; rs35912155; rs11362669; rs977610; rs2181610; rs9585267; rs2296116; rs9585270; rs9585259; rs7982619; rs9585205; rs35003302; rs10220015; rs35823298; rs34969571; rs11618807; rs9585147; rs12021159; rs7322953; rs11271366; rs7324313; rs7989192; rs9300563; rs9517874; rs9513677; rs9585160; rs7337684; rs35567603; rs36097438; rs34070975; rs11449148; rs9517804; rs13329008; rs9517823; rs9557322; rs12868239; rs11317797; rs12865200; rs34073523; rs9554643; rs28627688; rs9513639; rs35342610; rs12019528; rs35430864; rs34526549; rs9557283; rs12858482; rs36091331; rs7324907; rs35483940; rs7317490; rs8000287; rs10597168; rs9517881; rs11841929; rs9585154; rs9517846; rs9557270; rs34410535; rs35949973; rs34021200; rs10592053; rs34772610; rs34861520; rs9585152; rs34939381; rs35699728; rs7322521; rs9513642; rs1040996; rs35662060; rs35774183; rs9554635; rs34088240; rs7983817; rs9585224; rs34985378; rs2147624; rs7139645; rs9513651; rs9582346; rs3032477; rs34250062; rs10568410; rs3032445; rs12019531; rs12875806; rs34486737; rs34750084; rs12017299; rs11463686; rs7996829; rs9513669; rs11366826; rs9585230; rs4771345; rs2793765; rs9585227; rs4772234; rs2793766; rs41281114; rs10533615; rs9582332; rs12869202; rs35379429; rs12429721; rs34363176; rs5806134; rs34924763; rs28580696; rs9585220; rs11419450; rs9582339; rs1610001; rs9585217; rs7331354; rs7988332; rs7981233; rs12560998; rs2793737; rs9585149; rs35727678; rs12867987; rs4772226; rs10645961; rs34374186; rs12232034; rs10549994; rs36075018; rs2793755; rs9585194; rs35412408; rs5806131; rs11840479; rs9517855; rs35952137; rs35232603; rs12869622; rs35750065; rs10677584; rs9585201; rs35047223; rs35613958; rs7327405; rs12855403; rs9517850; rs35916895; rs12020709; rs9585183; rs9513679; rs34146197; rs34684474; rs34556034; rs11335800; rs36015545; rs11366362; rs9513662; rs35466928; rs35844376; rs35948793; rs9554627; rs11305509; rs12868722; rs4255648; rs12861278; rs2390358; rs36129096; rs34164127; rs9517851; rs35257355; rs34063235; rs9557314; rs35635065; rs7334733; rs9513646; rs34276188; rs10597169; rs35445984; rs10677824; rs9796290; rs35391365; rs2806291; rs28726082; rs927595; rs36015417; rs2793750; rs35508052; rs2806282; rs13378365; rs35423396; rs11278066; rs7994927; rs5806138; rs12016773; rs36044234; rs7984935; rs34500560; rs11309587; rs9585236; rs36145554; rs33916976; rs9557280; rs2793759; rs9517842; rs10642327; rs12875158; rs2806276; rs35128777; rs33929981; rs12866242; rs2793744; rs12021220; rs12867593; rs4771339; rs4772242; rs12856515; rs9557303; rs1963727; rs9513652; rs35624361; rs12862106; rs10645320; rs9585221; rs10648017; rs7325085; rs11343579; rs9557289; rs12873987; rs9582343; rs28373539; rs9585155; rs35229641; rs36013244; rs7992451; rs2806287; rs7986698; rs728604; rs35893746; rs9585204; rs28460044; rs10083293; rs34582077; rs2793747; rs12875920; rs9513641; rs10556030; rs5806135; rs9517812; rs34631016; rs9585219; rs9585212; rs9554638; rs9517873; rs34206687; rs9513659; rs36094711; rs9585144; rs9585177; rs7996041; rs34513643; rs7993488; rs34742862; rs35938901; rs12871842; rs9517852; rs2793743; rs34556416; rs12583116; rs12428299; rs28630466; rs5806132; rs9300559; rs34184534; rs35582976; rs35442779; rs35794092; rs12017446; rs28535907; rs35588884; rs36054864; rs11300050; rs35941109; rs11617836; rs9517807; rs7335906; rs12561426; rs35020187; rs9517870; rs9585156; rs35916119; rs28662865; rs9557326; rs12430026; rs35436226; rs9585253; rs34909317; rs35970090; rs7996371; rs16956897; rs11069380; rs12865204; rs9517880; rs35492194; rs2181606; rs34774913; rs35610893; rs9517843; rs9585228; rs7988250; rs34026761; rs4001025; rs34000442; rs9585176; rs9517865; rs9554628; rs33921953; rs9585191; rs10614481; rs9645897; rs9557264; rs7988572; rs12323058; rs5806139; rs11838666; rs35820957; rs9585184; rs35531654; rs9557300; rs7997298; rs33994560; rs7997104; rs11322280; rs7322080; rs9557275; rs35421489; rs35122845; rs36120094; rs2806294; rs10697990; rs5009289; rs9517836; rs9585150; rs12871547; rs9585241; rs35654270; rs9740926; rs34546130; rs9554622; rs9557274; rs1125310; rs10698265; rs28655761; rs7335847; rs34217364; rs7320067; rs34444426; rs9585222; rs12865205; rs9517822; rs12876701; rs34463702; rs11617075; rs34142988; rs28690058; rs35606459; rs7984121; rs4772232; rs11375965; rs10527051; rs34459686; rs4772243; rs2793757; rs10561602; rs35769084; rs2763937; rs9557279; rs34065607; rs35279065; rs28758716; rs9585255; rs35982336; rs11295981; rs35593548; rs9517833; rs9557285; rs2763941; rs12871537; rs34919433; rs34521848; rs35403713; rs34410635; rs4620824; rs9585145; rs4468465; rs34452564; rs9582334; rs4771338; rs7992348; rs35449822; rs34006709; rs5806136; rs9585238; rs35744796; rs7492046; rs7336931; rs13378364; rs9585196; rs10625169; rs10633371; rs35255826; rs9517858; rs28607319; rs10638638; rs9517848; rs12854991; rs34417938; rs35178164; rs9585235; rs28622077; rs34025247; rs7336414; rs12017577; rs35662106; rs34874271; rs34706273; rs12873782; rs9557294; rs9557265; rs35512772; rs35252192; rs11463227; rs9557299; rs35360400; rs12868198; rs10547821; rs35149509; rs35684540; rs10643696; rs11407509; rs2793740; rs10631675; rs34591731; rs11488858; rs35846449; rs9517828; rs11399409; rs9652119; rs11408587; rs4581571; rs4448786; rs9585180; rs9517894; rs2761160; rs9796140; rs2793739; rs10592189; rs9517839; rs9585232; rs9513676; rs36013148; rs11453486; rs12873787; rs9554630; rs11413739; rs2793768; rs17577328; rs9582330; rs11428657; rs11840697; rs10580515; rs12868144; rs34164966; rs9585254; rs12873329; rs34877692; rs4772228; rs13378360; rs9557292; rs9517853; rs34127469; rs5806140; rs34783138; rs34168768; rs36062611; rs9582349; rs7996029; rs9585215; rs34966114; rs2181611; rs9517868; rs34256215; rs34844714; rs35539387; rs9585229; rs2763936; rs4772231; rs34487469; rs12870132; rs4772244; rs10587468; rs9796139; rs7323206; rs12019527; rs9585214; rs35378080; rs5806137; rs35339021; rs1555592; rs9585158; rs9582341; rs34817821; rs12020266; rs34180901; rs34493491; rs11843458; rs35821572; rs9585192; rs2793788; rs11423267; rs35513599; rs35590185; rs9630323; rs35802185; rs9585174; rs34774349; rs34128794; rs9585237; rs7988847; rs5806133; rs12020817; rs34558107; rs9517849; rs9517826; rs9513657; rs10577448; rs9517806; rs9585197; rs2390303; rs1970474; rs34727243; rs9513668; rs5806130; rs10675151; rs9517834; rs2763942; rs9517883; rs9557278; rs10570896; rs7324908; rs9517840; rs2181609; rs7322341; rs12585649; rs9585181; rs12866164; rs9585163; rs9585179; rs35241030; rs10643154; rs35027014; rs35911559; rs28454189; rs9585146; rs9517890; rs12861546; rs34903136; rs12864654; rs12855629; rs11488857; rs4772248; rs7992906; rs9585218; rs4362246; rs34065473; rs34854735; rs12862668; rs2806289; rs35340874; rs2015510; rs35553024; rs35159870; rs9517809; rs9300560; rs36019690; rs10542003; rs28421311; rs7326701; rs3033587; rs9585182; rs34277836; rs35273988; rs34884800; rs9554640; rs12016925; rs9517859; rs9517882; rs9517845; rs9513643; rs9517903; rs28497020; rs34634591; rs10603999; rs11300591; rs34668722; rs11355981; rs35156803; rs10613474; rs9585209; rs35152575; rs5806141; rs7328182; rs4988681; rs4771346; rs9557281; rs9517841; rs7983978; rs9517854; rs9517875; rs34257176; rs35102124; rs35191910; rs12858356; rs28417881; rs9585202; rs4001024; rs9585193; rs9585151; rs34349227; rs36158602; rs34319588; rs34935488; rs12868025; rs35877939; rs12875051; rs35480092; rs12874188; rs36046210; rs1555591; rs11619740; rs7986124; rs4771337; rs17473738; rs11419451; rs2793767; rs2253561; rs2793753; rs9585247; rs35402626; rs35604496; rs7334160; rs2806299; rs7322262; rs9805698; rs9557324; rs34517548; rs11362747; rs34075621; rs7981210; rs9585148; rs2763935; rs869324; rs5806129; rs35113728; rs33913059; rs35215455; rs9513638; rs9517802; rs12876075; rs35123470; rs12874996; rs869325; rs35614015; rs1040998; rs10851106; rs11617237; rs12020463; rs12876007; rs17611025; rs1924102; rs1924103; rs2390337; rs2763932; rs2793783; rs35065101; rs4238223; rs4238224; rs4772250; rs4772253; rs6491518; rs7338383; rs7338818; rs7982361; rs8002910; rs9513637; rs9517914; rs9585276; rs9645895; rs9645896

# Macromolecular_Interacting_Partner_3_General_References:
Not Available

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8651

# Macromolecular_Interacting_Partner_4_Name:
OTTHUMP00000030471

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>
OTTHUMP00000030471MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPS
GSAPAVAAAAAQPGSYPALSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGW
FLGGQLNVSVNCLDQHVRKSPESVALIWERDEPGTEVRITYSPWLQMPCGP

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
16137

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.66

# Macromolecular_Interacting_Partner_4_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Lipid transport and metabolism

# Macromolecular_Interacting_Partner_4_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Signals:
Not Available

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
Q5TF43_HUMAN (Q5TF43)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
ACSS1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
ACSS1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:16091

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
AL080312

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_4_Locus:
Not Available

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
Not Available

# Macromolecular_Interacting_Partner_4_References:
Not Available

# Macromolecular_Interacting_Partner_5_ID:
8890

# Macromolecular_Interacting_Partner_5_Name:
CGI-14 protein variant

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>CGI14 protein variant
GAGSGWACLGDLGQVQSLNPGPAGHSVADLRAAEDAVWSGATFITHLFNAMLPFHHRDPG
IVGLLTSDRLPAGRCIFYGMIADGTHTNPAALRIAHRAHPQGLVLVTDAIPALGLGNGRH
TLGQQEVEVDGLTAYVAGERPDPLGPRSQPACQVAHDPPRACPLCSQGTKTLSGSIAPMD
VCVRHFLQATGQ

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
192

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
19973

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.84

# Macromolecular_Interacting_Partner_5_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_5_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Signals:
Not Available

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
62088282

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
Q59FV8_HUMAN (Q59FV8)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:24262

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>579 bp
GGGGCCGGCTCGGGGTGGGCCTGCTTGGGGGACCTGGGCCAGGTGCAAAGTCTGAATCCA
GGTCCCGCAGGGCACTCAGTGGCTGACCTGCGGGCGGCAGAGGATGCTGTGTGGAGCGGA
GCCACCTTCATCACCCACCTCTTCAACGCCATGCTGCCTTTCCACCACCGCGACCCAGGC
ATCGTGGGGCTCCTGACCAGCGACCGGCTGCCCGCAGGCCGCTGCATCTTCTATGGGATG
ATTGCAGATGGCACGCACACCAACCCCGCCGCCCTGCGGATCGCCCACCGTGCCCATCCC
CAGGGGCTGGTGCTGGTCACCGATGCCATCCCTGCCTTGGGCCTGGGCAACGGCCGGCAC
ACGCTGGGACAGCAGGAAGTGGAAGTGGACGGTCTGACGGCCTACGTGGCAGGTGAGCGC
CCTGACCCACTGGGTCCCAGGTCCCAGCCCGCATGCCAGGTGGCCCACGACCCCCCCAGA
GCCTGCCCTCTCTGCTCTCAAGGCACCAAGACGCTGAGTGGCAGCATAGCCCCAATGGAC
GTCTGTGTCCGGCACTTCCTGCAGGCCACAGGTCAGTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AB209351

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Locus:
Not Available

# Macromolecular_Interacting_Partner_5_SNPs:
Not Available

# Macromolecular_Interacting_Partner_5_General_References:
Not Available

# Macromolecular_Interacting_Partner_5_References:
Not Available

End of HMDB00042

Beginning of HMDB00043
# Accession_No:
HMDB00043

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-14 11:21:21

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Betaine

# Description:
Betaine or trimethylglycine is a methylated derivative of glycine.  It functions as a methyl donor in that it carries and donates methyl functional groups to facilitate necessary chemical processes. The donation of methyl groups is important to proper liver function, cellular replication, and detoxification reactions. Betaine also plays a role in the manufacture of carnitine and serves to protect the kidneys from damage. Betaine has also been of interest for its role in osmoregulation. As a drug, betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria. Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th Ed, p1341)

# Synonyms:
(Carboxymethyl)trimethylammonium hydroxide inner salt; (Trimethylammonio)acetate; 1-Carboxy-N,N,N-trimethylmethanaminium inner salt; 1-carboxy-N,N,N-trimethyl-Methanaminium; 1-carboxy-N,N,N-trimethyl-Methanaminium hydroxide; Abromine; Aminocoat; Betafin; Betafin BCR; Betafin BP; Betaine; Cystadane; Ektasolve EE; FinnStim; Glycine betaine; Glycocoll betaine; Glycylbetaine; Greenstim; Loramine AMB 13; Loramine AMB-13; Lycine; N,N,N-Trimethylglycine; Oxyneurine; Rubrine C; Trimethylaminoacetate; Trimethylaminoacetic acid; Trimethylglycine; Trimethylglycocoll; a-Earleine; alpha-Earleine; trimethylbetaine Glycine

# Chemical_IUPAC_Name:
2-trimethylammonioacetate

# Chemical_Formula:
C5H11NO2

# Chemical_Structure:
tbl_chemical:::HMDB00043_ZOOM.png:::119283151093782155

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00043_THUMB.png:::119283150910844650

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Salts

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
cation; anion; quaternary ammonium salt; carboxylic acid salt

# Taxonomy_Biofunction:
Osmolyte; Component of Glycine, serine and threonine metabolism; Component of Methionine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
117.07898

# Molecular_Weight_Avg:
117.14634

# Smiles_String_isomeric:
C[N+](C)(C)CC([O-])=O

# Smiles_String_canonical:
C[N+](C)(C)CC([O-])=O

# KEGG_Compound_ID:
C00719

# BioCyc_ID:
BETAINE

# PubChem_CID:
247

# PubChem_SID:
2165; 11537950; 7853805; 8145492; 10503467; 8150529; 150977; 12075420; 4422026; 841599; 3138572; 7978780; 7985507; 3985

# OMIM_ID:
250940

# Metagene_ID:
Not Available

# BiGG_ID:
35786

# Wikipedia_ID:
Betaine

# METLIN_ID:
287

# Ref_ID:
9357926; 12560353; 11522934; 12551843; 11569700; 11101581; 11737741; 12399266; 3546377; 9732980; 16082628; 16282556

# ChEBI_ID:
17750

# CAS_Registry_Number:
107-43-7

# InChI:
InChI=1/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3

# Synthesis_Reference:
Journal of Physical Chemistry  (1990),  94(5),  1768-74.

# Melting_Point:
293 oC ( Soicke, H., Fitoterapia 1988,  V59(1),  P73-5); 301 oC dec.

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
611.0 mg/mL at 19 oC [YALKOWSKY,SH & DANENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
1.86 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.69 [Predicted by ALOGPS]; -4.93 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Betaine.mol:::1132723803125187364

# SDF_File_[Text]:
tbl_chemical:::HMDB00043.sdf:::119283150576698389

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00043.pdb:::119283150743379361

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041001_P00_01_HW_1DP_PRESAT_expanded_2.gif:::114460751934022109

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041001_P00_01_HW_1DP_presat.zip:::117771063555967593

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041001_P00_01_HW_1DP_Assigned.png:::114659863448940034

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::107-43-7-presat_JM.GIF:::1132883787031709634

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041001_P00_01_HW_1DP_PRESAT_1.zip:::114460785426616486

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
tbl_cnmr:::041001_P00_01_HW_1DC_38.jpg:::114168476843860901

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041001_P00_01_HW_1DC_38.zip:::114168476840860186

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041001_P00_01_HW_1DC_38_Assigned.jpg:::114322768817422051

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041001_P00_01_HW_2DHSQC_29.jpg:::114495493377492504

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041001_P00_01_HW_2DHSQC_29.zip:::114495493416554525

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041001_P00_01_HW_2DHSQC_29_Assigned.jpg:::114495493433298286

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Betaine.gif:::1132732102000118802

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00043_peaks.txt:::1156309506995697027

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Betaine_C.gif:::1132737665729794101

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00043_peaks.txt:::1156310698608995963

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00043L.png:::117555262019868691; Medium Energy:tbl_ms:::HMDB00043M.png:::117555267104726345; High Energy:tbl_ms:::HMDB00043H.png:::117555270979784450

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000069.png:::116890825632897374

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000069.txt:::116890825660945219

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria

# Tissue_Location:
Adipose Tissue; Adrenal Cortex; Adrenal Gland; Bladder; Epidermis; Fibroblasts; Gonads; Gut; Intestine; Kidney; Liver; Liver Predominantly; Pancreas; Placenta; Platelet; Prostate; Skeletal Muscle; Skin; Spleen; Stratum Corneum; Testes; Testis

# deuterated:
No

# Biofluid_Location:
Blood; Breast Milk; Urine

# Concentration_[Normal]:
Urine	18.6 (4.868-32.4)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	3546377
Urine	49.6 (6.4-92.7)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9732980
Blood	82.0 (20.0-144.0)	umol/L	Adult:>18_yrs_old	Both	Normal	9732980 


# Concentration_[Abnormal]:
Urine	6.0 (0.0-16.0)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Lung Cancer	HMP experimental


# Associated_Disorders:
Lung Cancer; Prostate Cancer; Thalassemia Trait; Tumour Necrosis

# Pathway_Names:
Methionine metabolism

# Pathway_Images:
Methionine_Metabolism.jpg

# KEGG_Images:
map00271

# Pathway_Graphs:
Methionine_Metabolism_Graph.jpg

# Pathway_SBMLs:
Methionine_Metabolism.xml

# Metabolic_Enzyme_1_ID:
5831

# Metabolic_Enzyme_1_Name:
Betaine--homocysteine S-methyltransferase 1

# Metabolic_Enzyme_1_Synonyms:
Not Available

# Metabolic_Enzyme_1_Gene_Name:
BHMT

# Metabolic_Enzyme_1_Protein_Sequence:
>Betainehomocysteine Smethyltransferase 1
MPPVGGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLH
REFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIARQVADEGDALVAG
GVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKP
VAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARL
KAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCC
GFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASG
RPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFEKQKFKSQ

# Metabolic_Enzyme_1_Number_of_Residues:
406

# Metabolic_Enzyme_1_Molecular_Weight:
44999

# Metabolic_Enzyme_1_Theoretical_pI:
7.04

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  S-methyltransferase activity
Function:  homocysteine S-methyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline

# Metabolic_Enzyme_1_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00271  Methionine metabolism

# Metabolic_Enzyme_1_Reaction:
trimethylammonioacetate + L-homocysteine = dimethylglycine + L-methionine

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF02574:S-methyl_trans

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.1.1.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1522683

# Metabolic_Enzyme_1_SwissProt_ID:
BHMT1_HUMAN (Q93088)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
BHMT

# Metabolic_Enzyme_1_Geneatlas_id:
BHMT

# Metabolic_Enzyme_1_hgnc_id:
HGNC:1047

# Metabolic_Enzyme_1_PDB_ID:
1LT8

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1221 bp
ATGCCACCCGTTGGGGGCAAAAAGGCCAAGAAGGGCATCCTAGAACGTTTAAATGCTGGA
GAGATTGTGATTGGAGATGGAGGGTTTGTCTTTGCACTGGAGAAGAGGGGCTACGTAAAG
GCAGGACCCTGGACTCCTGAAGCTGCTGTGGAGCACCCAGAAGCAGTTCGCCAGCTTCAT
CGAGAGTTCCTCAGAGCTGGCTCAAACGTCATGCAGACCTTCACCTTCTATGCGAGTGAA
GACAAGCTGGAGAACAGGGGCAACTATGTCTTAGAGAAGATATCTGGGCAGGAAGTCAAT
GAAGCTGCTTGCGACATCGCCCGACAAGTGGCTGATGAAGGAGATGCTTTGGTAGCAGGA
GGAGTGAGTCAGACACCTTCATACCTTAGCTGCAAGAGTGAAACTGAAGTCAAAAAAGTA
TTTCTGCAACAGTTAGAGGTCTTTATGAAGAAGAACGTGGACTTCTTGATTGCAGAGTAT
TTTGAACACGTTGAAGAAGCTGTGTGGGCAGTTGAAACCTTGATAGCATCCGGTAAACCT
GTGGCAGCAACCATGTGCATTGGCCCAGAAGGAGATTTGCATGGCGTGCCCCCCGGCGAG
TGTGCAGTGCGCCTGGTGAAAGCAGGAGCATCCATCATTGGTGTGAACTGCCACTTTGAC
CCCACCATTAGTTTAAAAACAGTGAAGCTCATGAAGGAGGGCTTGGAGGCTGCCCAACTG
AAAGCTCACCTGATGAGCCAGCCCTTGGCTTACCACACTCCTGACTGCAACAAGCAGGGA
TTCATCGATCTCCCAGAATTCCCATTTGGACTGGAACCCAGAGTTGCCACCAGATGGGAT
ATTCAAAAATACGCCAGAGAGGCCTACAACCTGGGGGTCAGGTACATTGGCGGGTGCTGT
GGATTTGAGCCCTACCACATCAGGGCAATTGCAGAGGAGCTGGCCCCAGAAAGGGGCTTT
TTGCCACCAGCTTCAGAAAAACATGGCAGCTGGGGAAGTGGTTTGGACATGCACACCAAA
CCCTGGGTTAGAGCAAGGGCCAGGAAGGAATACTGGGAGAATCTTCGGATAGCCTCAGGC
CGGCCATACAACCCTTCAATGTCAAAGCCAGATGGCTGGGGAGTGACCAAAGGAACAGCC
GAGCTGATGCAGCAGAAAGAAGCCACAACTGAGCAGCAGCTGAAAGAGCTCTTTGAAAAA
CAAAAATTCAAATCACAGTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U50929

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_1_Locus:
5q13.1-q15

# Metabolic_Enzyme_1_SNPs:
rs3733890; rs585800; rs1002735; rs1050824; rs542852; rs649514; rs492842; rs651852; rs567754; rs6453430; rs10037045; rs506500; rs6862287; rs6875201; rs6894156; rs7700970; rs3797546; rs621678; rs622087; rs694290; rs16876548; rs4421087; rs10474577; rs573372; rs558133; rs612855; rs34504683; rs16876528; rs16876527; rs6893970; rs6860725; rs478667; rs16876547; rs34004238; rs686764; rs619100; rs1862227; rs11955042; rs35815247; rs3756548; rs562487; rs16876512; rs3756547; rs10037809; rs672347; rs1050825; rs672346; rs11541208; rs35041410; rs4703772; rs1804620; rs2909853; rs13164347; rs6893715; rs13160271; rs35064627; rs35826365; rs918417; rs34861837; rs34308482; rs35913757; rs34267463; rs35639243; rs1644005; rs35373899; rs5868950; rs35563215; rs4020527; rs35261961; rs35571558; rs10071440; rs35884202; rs34576335; rs7722216; rs10044894; rs35617181; rs11955653; rs1316776; rs1627316; rs16876498; rs16876500; rs16876503; rs1717566; rs1915705; rs1915706; rs2364596; rs2461248; rs2909854; rs490268; rs586199; rs600473; rs603896; rs617219; rs631305; rs644623; rs645112; rs7356530; rs7732845; rs955897; rs964320

# Metabolic_Enzyme_1_General_References:
8798461; 10075673; 9281325; 9681996; 12818402

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5433

# Metabolic_Enzyme_2_Name:
Choline dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_2_Synonyms:
CHD; CDH

# Metabolic_Enzyme_2_Gene_Name:
CHDH

# Metabolic_Enzyme_2_Protein_Sequence:
>Choline dehydrogenase, mitochondrial precursor
MWCLLRGLGRPGALARGALGQQQSLGARALASAGSESRDEYSYVVVGAGSAGCVLAGRLT
EDPAERVLLLEAGPKDVRAGSKRLSWKIHMPAALVANLCDDRYNWCYHTEVQRGLDGRVL
YWPRGRVWGGSSSLNAMVYVRGHAEDYERWQRQGARGWDYAHCLPYFRKAQGHELGASRY
RGADGPLRVSRGKTNHPLHCAFLEATQQAGYPLTEDMNGFQQEGFGWMDMTIHEGKRWSA
ACAYLHPALSRTNLKAEAETLVSRVLFEGTRAVGVEYVKNGQSHRAYASKEVILSGGAIN
SPQLLMLSGIGNADDLKKLGIPVVCHLPGVGQNLQDHLEIYIQQACTRPITLHSAQKPLR
KVCIGLEWLWKFTGEGATAHLETGGFIRSQPGVPHPDIQFHFLPSQVIDHGRVPTQQEAY
QVHVGPMRGTSVGWLKLRSANPQDHPVIQPNYLSTETDIEDFRLCVKLTREIFAQEALAP
FRGKELQPGSHIQSDKEIDAFVRAKADSAYHPSCTCKMGQPSDPTAVVDPQTRVLGVENL
RVVDASIMPSMVSGNLNAPTIMIAEKAADIIKGQPALWDKDVPVYKPRTLATQR

# Metabolic_Enzyme_2_Number_of_Residues:
594

# Metabolic_Enzyme_2_Molecular_Weight:
65402

# Metabolic_Enzyme_2_Theoretical_pI:
8.47

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  FAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  electron transport
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Choline + acceptor = betaine aldehyde + reduced acceptor

# Metabolic_Enzyme_2_Pathway:
map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_2_Reaction:
choline + acceptor = betaine aldehyde + reduced acceptor

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF05199:GMC_oxred_C;
PF00732:GMC_oxred_N

# Metabolic_Enzyme_2_Signals:
1-15

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.99.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
21759795

# Metabolic_Enzyme_2_SwissProt_ID:
CHDH_HUMAN (Q8NE62)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
CHDH

# Metabolic_Enzyme_2_Geneatlas_id:
CHDH

# Metabolic_Enzyme_2_hgnc_id:
HGNC:24288

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Mitochondrion (Potential)

# Metabolic_Enzyme_2_Gene_Sequence:
>1785 bp
ATGTGGTGTCTCCTACGAGGCCTGGGCCGGCCTGGAGCCCTGGCACGGGGAGCCCTGGGG
CAGCAGCAATCCCTGGGTGCCCGGGCCCTGGCCAGCGCAGGCTCTGAGAGCCGGGACGAG
TACAGCTATGTGGTGGTGGGCGCGGGCTCGGCGGGCTGCGTGCTGGCTGGGAGGCTCACG
GAGGACCCCGCCGAGCGCGTGCTGCTGCTGGAGGCCGGGCCCAAGGACGTGCGCGCGGGG
AGCAAGCGGCTCTCGTGGAAGATCCACATGCCCGCGGCCCTGGTGGCCAACCTGTGCGAC
GACAGGTACAACTGGTGCTACCACACAGAGGTGCAGCGGGGCCTGGACGGCCGCGTGCTG
TACTGGCCACGCGGCCGCGTCTGGGGTGGCTCCTCATCCCTCAATGCCATGGTCTACGTC
CGTGGGCACGCCGAGGACTACGAGCGCTGGCAGCGCCAGGGCGCCCGCGGCTGGGACTAC
GCGCACTGCCTGCCCTACTTCCGCAAGGCGCAGGGCCACGAGCTGGGCGCCAGCCGGTAC
CGGGGCGCCGATGGCCCGCTGCGGGTGTCCCGGGGCAAGACCAACCACCCGCTGCACTGC
GCATTCCTGGAGGCCACGCAGCAGGCCGGCTACCCGCTCACCGAGGACATGAATGGCTTC
CAGCAGGAGGGCTTCGGCTGGATGGACATGACCATCCATGAAGGCAAACGGTGGAGCGCA
GCCTGTGCCTACCTGCACCCAGCACTGAGCCGCACCAACCTCAAGGCCGAGGCCGAGACG
CTTGTGAGCAGGGTGCTATTTGAGGGCACCCGTGCAGTGGGCGTGGAGTATGTCAAGAAT
GGCCAGAGCCACAGGGCTTATGCCAGCAAGGAGGTGATTCTGAGTGGAGGTGCCATCAAC
TCTCCACAGCTGCTCATGCTCTCTGGCATCGGGAATGCTGATGACCTCAAGAAACTGGGC
ATCCCTGTGGTGTGCCACCTACCTGGGGTTGGCCAGAACCTGCAAGACCACCTGGAGATC
TACATTCAGCAGGCATGCACCCGCCCTATCACCCTCCATTCAGCACAGAAGCCCCTGCGG
AAGGTCTGCATTGGTCTGGAGTGGCTCTGGAAATTCACAGGGGAGGGAGCCACTGCCCAT
CTGGAAACAGGTGGGTTCATCCGCAGCCAGCCTGGGGTCCCCCACCCGGACATCCAGTTC
CATTTCCTGCCATCCCAAGTGATTGACCACGGGCGGGTCCCCACCCAGCAGGAGGCTTAC
CAGGTACATGTGGGGCCCATGCGGGGCACGAGTGTGGGCTGGCTCAAACTGAGAAGTGCC
AATCCCCAAGACCACCCTGTGATCCAGCCCAACTACTTGTCAACAGAAACTGATATTGAG
GATTTCCGTCTGTGTGTGAAGCTCACCAGAGAAATTTTTGCACAGGAAGCCCTGGCTCCG
TTCCGAGGGAAAGAGCTCCAGCCAGGAAGCCACATTCAGTCAGATAAAGAGATAGATGCC
TTTGTGCGGGCAAAAGCCGACAGCGCCTACCACCCCTCGTGCACCTGTAAGATGGGCCAG
CCCTCCGATCCCACTGCCGTGGTGGATCCGCAGACAAGGGTCCTCGGGGTGGAAAACCTC
AGGGTCGTCGATGCCTCCATCATGCCTAGCATGGTCAGCGGCAACCTGAACGCCCCCACA
ATCATGATCGCAGAGAAGGCAGCTGACATTATCAAGGGGCAGCCTGCACTCTGGGACAAA
GATGTCCCTGTCTACAAGCCCAGGACGCTGGCCACCCAGCGCTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
BC034502

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_2_Locus:
3p21.1

# Metabolic_Enzyme_2_SNPs:
rs9001; rs34974961; rs2241808; rs7641850; rs17053532; rs35375185; rs35064726; rs930367; rs4687590; rs6793451; rs6807783; rs4687591; rs9835128; rs2015498; rs6445607; rs4687747; rs920253; rs13317328; rs6445608; rs6801605; rs7643016; rs2118421; rs9812916; rs2289206; rs7620929; rs3774616; rs2289207; rs7647880; rs3774617; rs11718497; rs2276838; rs7632578; rs6804251; rs7626693; rs12634827; rs4687589; rs11716282; rs34500349; rs4687748; rs7634578; rs9855967; rs11914948; rs13321117; rs9854886; rs2884632; rs2196663; rs9824744; rs12637132; rs9877386; rs2289209; rs9836592; rs6445606; rs7625247; rs9863776; rs2241807; rs893368; rs2289208; rs11714712; rs4563403; rs4687744; rs11130381; rs4687588; rs12485507; rs4234642; rs17053530; rs12485510; rs12676; rs3209093; rs34336629; rs35642771; rs34905899; rs11391630; rs5849008; rs10663777; rs4687746; rs2118422; rs4687749; rs4687750; rs35580724; rs2164815; rs35890881; rs6807496; rs3079408; rs13080845; rs10636132; rs35892434; rs6782485; rs930366; rs10713985; rs10703989; rs34971544; rs35544897; rs11711312; rs9872403; rs13088829; rs35491417; rs9860224; rs13069101; rs13086547; rs9881815; rs34939200; rs34021192; rs34884918; rs11287903; rs9830723; rs34004134; rs35518479; rs34827407; rs9848701; rs7644115; rs34858459; rs28744591; rs28563804; rs34378181; rs10626142; rs3079411; rs10154841; rs1025689; rs10490844; rs11919668; rs14165; rs1561303; rs17641133; rs2232330; rs2232335; rs2232336; rs2232337; rs2232338; rs2276839; rs2289205; rs28385739; rs34241531; rs35403974; rs3733075; rs3755817; rs3774618; rs4261872; rs4364157; rs4371507; rs4687587; rs4687743; rs6445605; rs7614233; rs7620619; rs7627178; rs7636327; rs7637792; rs7650686; rs877483; rs877484; rs881883; rs893362; rs893363; rs9878562; rs999514; rs999515

# Metabolic_Enzyme_2_General_References:
Not Available

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5270

# Metabolic_Enzyme_3_Name:
Pyruvate dehydrogenase protein X component, mitochondrial precursor

# Metabolic_Enzyme_3_Synonyms:
Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; Lipoyl-containing pyruvate dehydrogenase complex component X; E3-binding protein; E3BP; proX

# Metabolic_Enzyme_3_Gene_Name:
PDHX

# Metabolic_Enzyme_3_Protein_Sequence:
>Pyruvate dehydrogenase protein X component, mitochondrial precursor
MAASWRLGCDPRLLRYLVGFPGRRSVGLVKGALGWSVSRGANWRWFHSTQWLRGDPIKIL
MPSLSPTMEEGNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDASDDGILAKIVVEEGSK
NIRLGSLIGLIVEEGEDWKHVEIPKDVGPPPPVSKPSEPRPSPEPQISIPVKKEHIPGTL
RFRLSPAARNILEKHSLDASQGTATGPRGIFTKEDALKLVQLKQTGKITESRPTPAPTAT
PTAPSPLQATAGPSYPRPVIPPVSTPGQPNAVGTFTEIPASNIRRVIAKRLTESKSTVPH
AYATADCDLGAVLKVRQDLVKDDIKVSVNDFIIKAAAVTLKQMPDVNVSWDGEGPKQLPF
IDISVAVATDKGLLTPIIKDAAAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNL
GMFGIDEFTAVINPPQACILAVGRFRPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDD
ELATRFLKSFKANLENPIRLA

# Metabolic_Enzyme_3_Number_of_Residues:
501

# Metabolic_Enzyme_3_Molecular_Weight:
54123

# Metabolic_Enzyme_3_Theoretical_pI:
9.09

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex

# Metabolic_Enzyme_3_Pathway:
Not Available

# Metabolic_Enzyme_3_Reaction:
Not Available

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00198:2-oxoacid_dh;
PF00364:Biotin_lipoyl;
PF02817:E3_binding

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.3.1.12

# Metabolic_Enzyme_3_GenBank_ID_Protein:
2316040

# Metabolic_Enzyme_3_SwissProt_ID:
ODPX_HUMAN (O00330)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
PDHX

# Metabolic_Enzyme_3_Geneatlas_id:
PDHX

# Metabolic_Enzyme_3_hgnc_id:
HGNC:21350

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_3_Gene_Sequence:
>1506 bp
ATGGCGGCCTCCTGGAGGCTGGGCTGTGATCCGCGGCTGCTGCGTTATCTTGTGGGCTTC
CCTGGCTGCCGAAGCGTAGGGCTGGTGAAGGGGGCTCTTGGGTGGTCCGTAAGCCGCGGA
GCTAATTGGAGATGGTTTCACAGCACGCAGTGGCTTCGGGGTGATCCCATTAAGATACTA
ATGCCATCACTGTCTCCTACAATGGAAGAAGGAAACATTGTGAAATGGCTGAAAAAGGAA
GGTGAAGCGGTGAGTGCTGGAGATGCATTATGTGAAATTGAGACTGACAAAGCTGTGGTT
ACCTTAGATGCAAGTGATGATGGAATCTTGGCCAAAATCGTGGTTGAAGAAGGAAGTAAA
AATATACGGCTAGGTTCACTAATTGGTTTGATAGTAGAAGAAGGAGAAGATTGGAAACAT
GTTGAAATTCCCAAAGACGTAGGTCCTCCACCACCAGTTTCAAAACCTTCAGAGCCTCGC
CCCTCACCAGAACCACAGATTTCCATCCCTGTCAAGAAGGAACACATACCCGGGACACTA
CGGTTCCGTTTAAGTCCAGCTGCCCGCAATATTCTGGAAAAACACTCACTGGATGCTAGC
CAGGGCACAGCCACTGGCCCTCGGGGGATATTCACTAAAGAGGATGCTCTCAAACTTGTC
CAGTTGAAACAAACGGGCAAGATTACCGAGTCCAGACCAACTCCAGCCCCCACAGCCACT
CCCACAGCACCTTCGCCCCTACAGGCCACATCTGGACCATCTTATCCCCGGCCTGTGATC
CCACCAGTATCAACTCCCGGACAACCCAATGCAGTGGGCACATTCACTGAAATCCCCGCC
AGCAATATTCGAAGAGTTATTGCCAAGAGATTAACTGAATCTAAAAGTACTGTACCTCAT
GCATATGCTACTGCTGACTGTGACCTTGGAGCTGTTTTAAAAGTTAGGCAAGATCTGGTC
AAAGATGACATTAAAGTATCAGTAAATGATTTTATCATCAAGGCAGCAGCTGTTACCCTT
AAACAAATGCCAGATGTTAATGTAAGCTGGGATGGAGAGGGCCCAAAGCAACTGCCATTT
ATTGACATTTCAGTGGCTGTGGCAACAGATAAAGGCTTACTTACTCCAATCATAAAAGAT
GCTGCTGCTAAAGGTATCCAGGAAATTGCTGACTCTGTAAAGGCTCTATCAAAGAAAGCA
AGAGATGGAAAATTGTTGCCTGAAGAATACCAAGGAGGATCTTTTAGTATTTCCAACTTG
GGGATGTTTGGCATCGACGAATTTACTGCAGTGATTAACCCTCCTCAGGCCTGCATTTTG
GCGGTTGGGAGGTTCCGACCTGTGCTGAAGCTCACTGAGGATGAAGAGGGAAATGCCAAA
CTGCAGCAGCGCCAGCTCATAACAGTCACAATGTCAAGTGACAGTCGAGTGGTTGATGAC
GAACTGGCAACCAGGTTTCTTAAAAGTTTTAAAGCAAACCTAGAGAATCCTATCCGACTT
GCCTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
AF001437

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_3_Locus:
11p13

# Metabolic_Enzyme_3_SNPs:
rs11539202; rs497582; rs34582941; rs7808; rs9326; rs3210067; rs16926653; rs3210066; rs3210064; rs3210065; rs2732555; rs2986408; rs2915205; rs2986412; rs2985149; rs2761820; rs2915197; rs2985150; rs2956105; rs2986406; rs511776; rs2956081; rs2956126; rs2243929; rs2956128; rs496653; rs2986404; rs2956077; rs1326945; rs2986409; rs504034; rs1991648; rs2985403; rs2732551; rs1998912; rs2762963; rs614668; rs2915203; rs2915202; rs733567; rs7940226; rs2956107; rs7938962; rs7115217; rs7947650; rs7950996; rs746124; rs2762954; rs11032937; rs2956106; rs2732557; rs2915190; rs496620; rs12294125; rs2025779; rs2915201; rs3852517; rs2767047; rs7925118; rs2986403; rs2762956; rs2915199; rs2956103; rs2915227; rs2915198; rs2986402; rs2025780; rs2915191; rs2732559; rs2762962; rs2915189; rs2762959; rs2915183; rs2762953; rs2986410; rs3794165; rs7941930; rs12279553; rs12274490; rs11032927; rs17435469; rs6484749; rs7119958; rs17348711; rs2732565; rs6484747; rs2767044; rs2986405; rs11032935; rs3794163; rs1326944; rs17433496; rs2915200; rs2956098; rs2243948; rs10488801; rs12292719; rs12286538; rs10836326; rs3852515; rs10488803; rs12270487; rs1011518; rs520658; rs2031686; rs2915193; rs7119807; rs2181876; rs17434946; rs10488804; rs724714; rs7104984; rs11608116; rs7479823; rs2732558; rs10488802; rs11032928; rs7117719; rs12294047; rs2985402; rs7952208; rs12275339; rs2956100; rs2767038; rs11605993; rs967505; rs2767043; rs2915204; rs2253128; rs2985405; rs11032963; rs2732562; rs6484748; rs2217479; rs3794166; rs967506; rs10836324; rs11600718; rs2767035; rs17348697; rs7114970; rs12283763; rs11032948; rs3794161; rs11032938; rs11032926; rs7119524; rs12099088; rs10742331; rs3932539; rs10836323; rs17363135; rs12275275; rs7941937; rs11032944; rs2956123; rs2915181; rs2985401; rs589626; rs568932; rs2732554; rs7932205; rs11032956; rs2732564; rs12288594; rs7117023; rs11032943; rs17434808; rs10768110; rs9666748; rs10768106; rs9666905; rs12295537; rs2031687; rs1011519; rs10836327; rs11032960; rs11032940; rs2956087; rs2767034; rs12270826; rs11032942; rs3118073; rs522436; rs2761819; rs12289996; rs10768105; rs9971607; rs2761821; rs17349298; rs12099276; rs12286412; rs9667504; rs2986413; rs2281809; rs12288628; rs7924969; rs12283472; rs7929287; rs2761822; rs16926479; rs2762960; rs2915187; rs11601737; rs2956102; rs10466392; rs7936426; rs10742332; rs2767039; rs10768108; rs1746940; rs12276735; rs9665797; rs17362114; rs2985151; rs7931814; rs2762957; rs10488805; rs12295452; rs2732560; rs12282098; rs1748073; rs12385808; rs11032941; rs2956099; rs11606580; rs2915195; rs3763924; rs10488807; rs4375465; rs1409717; rs2732563; rs7115153; rs12295408; rs7105901; rs4417241; rs2767042; rs9667348; rs7945524; rs2986407; rs2031685; rs16926457; rs2956101; rs2767037; rs3794157; rs2767036; rs11032969; rs3794162; rs12275911; rs2985404; rs10488806; rs10836322; rs11605972; rs956130; rs1049333; rs1049311; rs35560997; rs34398018; rs17850649; rs36047324; rs3210068; rs1063351; rs4756180; rs34358212; rs2956104; rs3980625; rs28677799; rs12294397; rs7936015; rs11032945; rs12282419; rs5791023; rs2767046; rs11032966; rs34108758; rs3980628; rs2767045; rs3045650; rs11032957; rs12283866; rs12292363; rs34547087; rs36061427; rs35950140; rs11032936; rs3831063; rs12279631; rs7924507; rs10734433; rs12800045; rs12792494; rs34160844; rs2915196; rs11347782; rs11032971; rs12789653; rs17349031; rs12281172; rs34095132; rs2986411; rs35979260; rs12799433; rs526240; rs2956124; rs34514805; rs502063; rs11032925; rs11291680; rs28450089; rs35931541; rs12292931; rs34104501; rs33992348; rs35384167; rs12417952; rs860731; rs2274134; rs28475621; rs12807481; rs28682443; rs7109473; rs35258745; rs679919; rs3841705; rs11603724; rs11032952; rs34466417; rs12282382; rs35802689; rs7948977; rs28626757; rs3118498; rs12275277; rs3044759; rs837014; rs10709327; rs5791024; rs12279549; rs11032934; rs7123633; rs3215780; rs12795625; rs34345153; rs3980627; rs12799276; rs35335444; rs2732556; rs11032954; rs3980692; rs34890448; rs35176869; rs11032967; rs12270152; rs11032962; rs11032950; rs12272825; rs36026065; rs34896834; rs33975041; rs494892; rs11824801; rs12286583; rs12804006; rs11032929; rs34570842; rs12292505; rs2915192; rs2477157; rs34797155; rs2767040; rs12291039; rs12294594; rs2732561; rs12099355; rs3118071; rs12281384; rs12273153; rs12279952; rs2761823; rs9630149; rs3852519; rs2956127; rs33982446; rs11032961; rs3891918; rs35345329; rs12276679; rs12280293; rs12274680; rs5791025; rs3852516; rs3118072; rs35425265; rs34867844; rs12805200; rs11032959; rs12288060; rs34515348; rs34937302; rs4756182; rs11032931; rs10734430; rs10742330; rs4486662; rs12289218; rs7936983; rs1430857; rs11032933; rs11032970; rs7938431; rs11600805; rs2915194; rs11032947; rs1409718; rs12385809; rs7123595; rs11296610; rs7945013; rs10633958; rs12274383; rs11032958; rs4756181; rs35740352; rs11032964; rs12286442; rs35362345; rs11032951; rs12789820; rs12283435; rs10742329; rs11032932; rs10580926; rs11032946; rs35919979; rs11032939; rs12416846; rs12269970; rs35371988; rs41512444; rs35227178; rs35090822; rs3852518; rs35664323; rs17364197; rs28675015; rs2732566; rs1049306; rs1049307; rs11605600; rs11606257; rs11606871; rs12226454; rs12273271; rs12281914; rs12285752; rs12293733; rs12293749; rs12361884; rs12574930; rs12785657; rs1326947; rs1326948; rs16926673; rs16926689; rs17347979; rs17436343; rs1887229; rs2016814; rs2016821; rs2025776; rs2025777; rs2116084; rs2762951; rs2762969; rs2767033; rs2915208; rs2956108; rs2956109; rs2956110; rs2956111; rs2956112; rs2956113; rs2956114; rs2956116; rs2956120; rs2986414; rs2986417; rs2986418; rs2986420; rs2986421; rs3763925; rs3763926; rs3763929; rs3763930; rs3763931; rs3763932; rs3763933; rs3763934; rs3763935; rs3763937; rs3794170; rs3794171; rs3794172; rs3818393; rs3818396; rs3818397; rs3818401; rs7109857; rs7110223; rs7113708; rs7116411; rs7126300; rs7126659; rs7129830; rs7484223; rs891546; rs984690

# Metabolic_Enzyme_3_General_References:
9242632; 9399911; 9467010; 9110174

# Metabolic_Enzyme_3_References:
11223528; 14612446; 7592481; 7898450

# Metabolic_Enzyme_4_ID:
6833

# Metabolic_Enzyme_4_Name:
Ephrin type-B receptor 2 precursor

# Metabolic_Enzyme_4_Synonyms:
Tyrosine-protein kinase receptor EPH-3; DRT; Receptor protein-tyrosine kinase HEK5; ERK; Renal carcinoma antigen NY-REN-47

# Metabolic_Enzyme_4_Gene_Name:
EPHB2

# Metabolic_Enzyme_4_Protein_Sequence:
>Ephrin typeB receptor 2 precursor
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQ
VCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADF
DSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLY
CNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGA
TNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNI
ICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPF
SPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSE
YNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIQEK
LPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPF
TYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYT
EKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTV
IQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTY
TSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIE
QDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGI
NLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTL
AGHQKKILNSIQVMRAQMNQIQSVEGQPLARRPRATGRTKRCQPRDVTKKTCNSNDGKKK
GMGKKKTDPGRGREIQGIFFKEDSHKESNDCSCGG

# Metabolic_Enzyme_4_Number_of_Residues:
1055

# Metabolic_Enzyme_4_Molecular_Weight:
117494

# Metabolic_Enzyme_4_Theoretical_pI:
6.51

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein-tyrosine kinase activity
Function:  transmembrane receptor protein tyrosine kinase activity
Function:  ephrin receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  enzyme linked receptor protein signaling pathway
Process:  transmembrane receptor protein tyrosine kinase signaling pathway
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Receptor for members of the ephrin-B family

# Metabolic_Enzyme_4_Pathway:
Not Available

# Metabolic_Enzyme_4_Reaction:
Not Available

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01404:Ephrin_lbd;
PF00041:fn3;
PF07714:Pkinase_Tyr;
PF00536:SAM_1

# Metabolic_Enzyme_4_Signals:
1-18

# Metabolic_Enzyme_4_Transmembrane_Regions:
544-564

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.7.10.1

# Metabolic_Enzyme_4_GenBank_ID_Protein:
495678

# Metabolic_Enzyme_4_SwissProt_ID:
EPHB2_HUMAN (P29323)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
EPHB2

# Metabolic_Enzyme_4_Geneatlas_id:
EPHB2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:3393

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Metabolic_Enzyme_4_Gene_Sequence:
>2946 bp
ATGTGGGTTCCAGTCCTAGCCCTGCCTGTGTGCACTTATGCAGAAACGCTAATGGACTCC
ACTACAGCGACTGCTGAGCTGGGCTGGATGGTGCATCCTCCATCAGGGTGGGAAGAGGTG
AGTGGCTACGATGAGAACATGAACACGATCCGCACGTACCAGGTGTGCAACGTGTTTGAG
TCAAGCCAGAACAACTGGCTACGGACCAAGTTTATCCGGCGCCGTGGCGCCCACCGCATC
CACGTGGAGATGAAGTTTTCGGTGCGTGACTGCAGCAGCATCCCCAGCGTGCCTGGCTCC
TGCAAGGAGACCTTCAACCTCTATTACTATGAGGCTGACTTTGACTCGGCCACCAAGACC
TTCCCCAACTGGATGGAGAATCCATGGGTGAAGGTGGATACCATTGCAGCCGACGAGAGC
TTCTCCCAGGTGGACCTGGGTGACCGCGTCATGAAAATCAACACCGAGGTGCGGAGCTTC
GGACCTGTGTCCCGCAGCGGCTTCTACCTGGCCTTCCAGGACTATGGCGGCTGCATGTCC
CTCATCGCCGTGCGTGTCTTCTACCGCAAGTGCCCCCGCATCATCCAGAATGGCGCCATC
TTCCAGGAAACCCTGTCGGGGGCTGAGAGCACATCGCTGGTGGCTGCCCGGGGCAGCTGC
ATCGCCAATGCGGAAGAGGTGGATGTACCCATCAAGCTCTACTGTAACGGGGACGGCGAG
TGGCTGGTGCCCATCGGGCGCTGCATGTGCAAAGCAGGCTTCGAGGCCGTTGAGAATGGC
ACCGTCTGCCGAGGTTGTCCATCTGGGACTTTCAAGGCCAACCAAGGGGATGAGGCCTGT
ACCCACTGTCCCATCAACAGCCGGACCACTTCTGAAGGGGCCACCAACTGTGTCTGCCGC
AATGGCTACTACAGAGCAGACCTGGACCCCCTGGACATGCCCTGCACAACCATCCCCTCC
GCGCCCCAGGCTGTGATTTCCAGTGTCAATGAGACCTCCCTCATGCTGGAGTGGACCCCT
CCCCGCGACTCCGGAGGCCGAGAGGACCTCGTCTACAACATCATCTGCAAGAGCTGTGGC
TCGGGCCGGGGTGCCTGCACCCGCTGCGGGGACAATGTACAGTACGCACCACGCCAGCTA
GGCCTGACCGAGCCACGCATTTACATCAGTGACCTGCTGGCCCACACCCAGTACACCTTC
GAGATCCAGGCTGTGAACGGCGTTACTGACCAGAGCCCCTTCTCGCCTCAGTTCGCCTCT
GTGAACATCACCACCAACCAGGCAGCTCCATCGGCAGTGTCCATCATGCATCAGGTGAGC
CGCACCGTGGACAGCATTACCCTGTCGTGGTCCCAGCCAGACCAGCCCAATGGCGTGATC
CTGGACTATGAGCTGCAGTACTATGAGAAGCAGGAGCTCAGTGAGTACAACGCCACAGCC
ATAAAAAGCCCCACCAACACGGTCACCGTGCAGGGCCTCAAAGCCGGCGCCATCTATGTC
TTCCAGGTGCGGGCACGCACCGTGGCAGGCTACGGGCGCTACAGCGGCAAGATGTACTTC
CAGACCATGACAGAAGCCGATTACCAGACAAGCATCCAGGAGAAGTTGCCACTCATCATC
GGCTCCTCGGCCGCTGGCCTGGTCTTCCTCATTGCTGTGGTTGTCATCGCCATCGTGTGT
AACAGACGGGGGTTTGAGCGTGCTGACTCGGAGTACACGGACAAGCTGCAACACTACACC
AGTGGCCACATGACCCCAGGCATGAAGATCTACATCGATCCTTTCACCTACGAGGACCCC
AACGAGGCAGTGCGGGAGTTTGCCAAGGAAATTGACATCTCCTGTGTCAAAATTGAGCAG
GTGATCGGAGCAGGGGAGTTTGGCGAGGTCTGCAGTGGCCACCTGAAGCTGCCAGGCAAG
AGAGAGATCTTTGTGGCCATCAAGACGCTCAAGTCGGGCTACACGGAGAAGCAGCGCCGG
GACTTCCTGAGCGAAGCCTCCATCATGGGCCAGTTCGACCATCCCAACGTCATCCACCTG
GAGGGTGTCGTGACCAAGAGCACACCTGTGATGATCATCACCGAGTTCATGGAGAATGGC
TCCCTGGACTCCTTTCTCCGGCAAAACGATGGGCAGTTCACAGTCATCCAGCTGGTGGGC
ATGCTTCGGGGCATCGCAGCTGGCATGAAGTACCTGGCAGACATGAACTATGTTCACCGT
GACCTGGCTGCCCGCAACATCCTCGTCAACAGCAACCTGGTCTGCAAGGTGTCGGACTTT
GGGCTCTCACGCTTTCTAGAGGACGATACCTCAGACCCCACCTACACCAGTGCCCTGGGC
GGAAAGATCCCCATCCGCTGGACAGCCCCGGAAGCCATCCAGTACCGGAAGTTCACCTCG
GCCAGTGATGTGTGGAGCTACGGCATTGTCATGTGGGAGGTGATGTCCTATGGGGAGCGG
CCCTACTGGGACATGACCAACCAGGATGTAATCAATGCCATTGAGCAGGACTATCGGCTG
CCACCGCCCATGGACTGCCCAGCTGCCCTGCACCAACTCATGCTGGACTGTTGGCAGAAG
GACCGCAACCACCGGCCCAAGTTCGGCCAAATTGTCAACACGCTAGACAAGATGATCCGC
AATCCCAACAGCCTCAAAGCCATGGCGCCCCTCTCCTCTGGCATCAACCTGCCGCTGCTG
GACCGCACGATCCCCGACTACACCAGCTTTAACACGGTGGACGAGTGGCTGAAGGCCATC
AAGATGGGGCAGTACAAGGAGAGCTTCGCCAATGCCGGCTTCACCTCCTTTGACGTCGTG
TCTCAGATGATGATGGAGGACATTCTCCGGGTTGGGGTCACTTTGGCTGGCCACCAGAAA
AAAATCCTGAACAGTATCCAGGTGATGCGGGCGCAGATGAACCAGATTCAGTCTGTGGAG
GTTTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
D31661

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_4_Locus:
1p36.1-p35

# Metabolic_Enzyme_4_SNPs:
rs35882952; rs36069879; rs309472; rs2295022; rs2229871; rs1982227; rs1561624; rs751022; rs2222111; rs309473; rs908503; rs2176273; rs882025; rs10753547; rs2165331; rs2817885; rs10917300; rs10917288; rs2817904; rs4612601; rs6426770; rs6426766; rs6703896; rs2817881; rs10917284; rs7521936; rs10917317; rs1318720; rs876685; rs6673115; rs963113; rs7536195; rs6426771; rs2582021; rs10799760; rs6670405; rs309479; rs1465889; rs6659914; rs6660612; rs4654814; rs2817903; rs1561625; rs6662622; rs6695566; rs6698922; rs6701399; rs10799764; rs2817907; rs893966; rs751024; rs309485; rs10753541; rs2817900; rs10799770; rs309499; rs2582022; rs116119; rs10917323; rs4655135; rs4654824; rs935039; rs10753545; rs893960; rs4655097; rs10799761; rs7530478; rs4233292; rs873296; rs10753539; rs12407525; rs4655107; rs4655128; rs6687094; rs3935109; rs7519206; rs893961; rs4655130; rs2817896; rs10799765; rs10917312; rs750012; rs6672700; rs4654819; rs2817901; rs10799769; rs7554093; rs4361967; rs4263970; rs7528104; rs6426763; rs7541752; rs751023; rs7413155; rs2165332; rs11578621; rs4655131; rs294231; rs2817876; rs10917283; rs882024; rs309475; rs2986657; rs10917325; rs10799766; rs893964; rs11803370; rs4654815; rs1561628; rs12043268; rs10917307; rs6667289; rs12562997; rs4655114; rs12028458; rs4654820; rs10733034; rs4506436; rs2869513; rs7340102; rs12410872; rs2138542; rs10465543; rs1516526; rs10917314; rs4655093; rs309480; rs6655962; rs12074571; rs309482; rs6683698; rs2119319; rs7535750; rs177927; rs10799771; rs6661718; rs4390147; rs4655123; rs4654818; rs893969; rs2904122; rs10799772; rs12076863; rs2582032; rs10442639; rs12076351; rs6664696; rs4347183; rs6687487; rs309503; rs309486; rs11808976; rs7521813; rs2817909; rs6695066; rs2675494; rs2817882; rs12131925; rs4655120; rs10917285; rs16827697; rs12090415; rs10917324; rs4654821; rs4655134; rs2817893; rs12723359; rs6426769; rs6694899; rs4654823; rs11807221; rs1122210; rs1866792; rs7516175; rs2582036; rs6426764; rs12723691; rs12404289; rs17488885; rs4655094; rs7549224; rs734445; rs2119320; rs6664926; rs12061624; rs12401695; rs12724658; rs893962; rs6426772; rs11801544; rs12410054; rs12045966; rs10917281; rs6700141; rs1866790; rs12410046; rs12033902; rs2817902; rs1010948; rs2869511; rs10917305; rs2817872; rs1440576; rs11811221; rs309502; rs6667416; rs4654817; rs12566963; rs16827672; rs1554211; rs10799759; rs2869512; rs309501; rs2043970; rs908502; rs4600017; rs10753544; rs4655121; rs11579491; rs1561622; rs6675651; rs4147362; rs6686970; rs4655100; rs11800828; rs4601555; rs309476; rs6426768; rs10917320; rs10917318; rs2043969; rs1866797; rs2582018; rs1440577; rs2176274; rs16827555; rs4654825; rs309500; rs2817912; rs6686906; rs893968; rs4654826; rs4503323; rs4291474; rs10799763; rs309497; rs12564658; rs16827678; rs1010011; rs16827699; rs4655111; rs4655117; rs4655099; rs16827484; rs6426767; rs4655136; rs2765852; rs10465531; rs6692683; rs309481; rs4655129; rs309488; rs17435718; rs2817913; rs6688933; rs4073886; rs11802208; rs2218194; rs309498; rs309504; rs17436065; rs16827686; rs309478; rs2582033; rs1002434; rs6685431; rs2582020; rs2746331; rs12746324; rs10732280; rs1440578; rs2817914; rs908500; rs4655133; rs6668788; rs4655105; rs10737467; rs10917313; rs309487; rs6426762; rs12405683; rs2582026; rs16827666; rs4297260; rs6700664; rs309543; rs10157808; rs4655132; rs6697530; rs4233294; rs11801383; rs991409; rs4654822; rs6700554; rs6658894; rs4655095; rs12730142; rs6675629; rs12239985; rs6426765; rs6703663; rs7541869; rs1866794; rs12730147; rs2817910; rs2817898; rs2765854; rs11589153; rs4655104; rs4655127; rs16827635; rs3122405; rs4589082; rs17435615; rs12093721; rs12143574; rs309495; rs3738296; rs10917322; rs10753546; rs4655101; rs12408248; rs170129; rs12039391; rs17488348; rs10917327; rs4233295; rs10917290; rs10917297; rs16827638; rs11581239; rs3935110; rs11585659; rs12411186; rs17436434; rs2165330; rs6689771; rs11587921; rs7546953; rs4655113; rs12133964; rs11589563; rs16827504; rs6697737; rs2176272; rs10917304; rs12086772; rs2817874; rs2817886; rs2582016; rs10917296; rs10917321; rs7521053; rs2582019; rs10917289; rs10917282; rs12049176; rs2203609; rs12131718; rs10753540; rs2675493; rs10799768; rs7545588; rs11802220; rs4655124; rs309471; rs16827538; rs12074138; rs2817887; rs2582035; rs6666706; rs1866791; rs16827646; rs10917319; rs4655119; rs309474; rs2817889; rs16827709; rs4655109; rs16827692; rs10799762; rs12731889; rs12062524; rs4610978; rs2746332; rs2582023; rs10917308; rs11576929; rs309464; rs12027585; rs16827653; rs4233296; rs4655110; rs1561627; rs12074315; rs4655125; rs4655098; rs12043267; rs10917306; rs4655102; rs10158095; rs2817888; rs12085307; rs10917287; rs10917280; rs12408669; rs7517616; rs6689527; rs309484; rs3934847; rs4427376; rs2817905; rs172417; rs10917295; rs6693330; rs12732926; rs6658621; rs4654816; rs12402508; rs6663298; rs4655106; rs7540682; rs1467416; rs12116772; rs10917286; rs4655108; rs908501; rs17487259; rs10753543; rs172635; rs16827476; rs6682233; rs4233293; rs16827502; rs12564000; rs2746336; rs10917309; rs7549431; rs4655103; rs12035865; rs6665618; rs10917299; rs309477; rs12062379; rs10917292; rs309465; rs2203608; rs309483; rs6679387; rs12562131; rs309505; rs6660673; rs2869056; rs294219; rs1054792; rs28936395; rs35847739; rs1371869; rs34273063; rs12083517; rs2675498; rs41266949; rs34626029; rs34608691; rs34306640; rs4654813; rs35500173; rs12746622; rs2493343; rs5773024; rs35435930; rs35842051; rs12731911; rs34657020; rs34763217; rs4644461; rs12749431; rs36212827; rs10917291; rs2493344; rs34345925; rs2817879; rs2817877; rs12751494; rs10799767; rs12039839; rs12064951; rs10917298; rs34123004; rs11581391; rs3971878; rs4488003; rs12141642; rs41266947; rs2817890; rs28649787; rs5773019; rs35001652; rs12027546; rs12723992; rs12730135; rs10442640; rs12567513; rs28445955; rs2582025; rs34057025; rs34956800; rs34765685; rs35802955; rs11351118; rs4654827; rs4655126; rs35231501; rs12125570; rs12751340; rs6669666; rs10599403; rs2817873; rs10917310; rs7529044; rs34217967; rs35864794; rs34240500; rs5773020; rs10667863; rs11272230; rs3971877; rs309468; rs11435992; rs36155921; rs4484898; rs12742143; rs12079256; rs35652771; rs28709833; rs34926160; rs35875853; rs34707209; rs35674202; rs34305335; rs10917303; rs9887784; rs1866796; rs2765853; rs10753542; rs28575426; rs12090702; rs5773015; rs12760811; rs2675496; rs35319777; rs12751344; rs34423675; rs35102609; rs12748866; rs34321396; rs34241415; rs4417035; rs12749670; rs35086321; rs2817878; rs34048979; rs10672820; rs12094975; rs893963; rs6699648; rs12755288; rs12142672; rs11338643; rs12746926; rs920483; rs12061829; rs35994351; rs34708969; rs4610979; rs34967134; rs5773025; rs10917293; rs7536952; rs2765849; rs34244599; rs10605593; rs2582027; rs12080301; rs28696733; rs35968324; rs35345582; rs12046210; rs35957296; rs34247144; rs12085654; rs35501059; rs309470; rs11433075; rs10917316; rs35244192; rs6661451; rs12066464; rs309467; rs12076355; rs1926233; rs12034943; rs12048514; rs12025232; rs12060512; rs41307781; rs34722490; rs12730314; rs2675497; rs35995262; rs36068535; rs12086938; rs12138477; rs12760781; rs28433939; rs1866795; rs35099386; rs34795220; rs28655115; rs35072143; rs35153237; rs5773016; rs2119318; rs35660411; rs2675495; rs2817897; rs33935213; rs12401904; rs2817911; rs1470136; rs7530437; rs35686583; rs34122990; rs6662444; rs10917294; rs16827649; rs4655096; rs12727687; rs34947049; rs12085264; rs34039353; rs35971603; rs35348742; rs11588572; rs33934364; rs4233291; rs3935111; rs34696131; rs7545400; rs2817883; rs34171889; rs6697948; rs34089016; rs35360906; rs35521278; rs10917315; rs34743995; rs2256554; rs2493341; rs5773014; rs11581431; rs9943047; rs12026627; rs35595257; rs12725821; rs35243071; rs34104306; rs35850344; rs28563955; rs2817908; rs2817875; rs35651467; rs893965; rs34633057; rs7514049; rs34101402; rs36090813; rs34886654; rs35189646; rs28493134; rs34809969; rs34809074; rs2165333; rs12116671; rs34582119; rs12409124; rs34790056; rs34009512; rs12731103; rs35800840; rs28536506; rs5773026; rs1561626; rs12068348; rs34093929; rs12730148; rs9659857; rs34659042; rs34987424; rs11579071; rs35816172; rs33977796; rs2817906; rs12065377; rs28420849; rs2083500; rs10583422; rs34735800; rs2817871; rs12562447; rs34300874; rs28538498; rs34715725; rs2582015; rs35711504; rs35203503; rs2817884; rs10711518; rs7524041; rs5773017; rs10917301; rs36050579; rs34699835; rs35994981; rs12070186; rs10583420; rs10917279; rs33973506; rs35329318; rs12760655; rs7515292; rs4654811; rs12730141; rs12751331; rs35445066; rs309466; rs35103352; rs2119317; rs968789; rs309496; rs1465890; rs12083803; rs34409047; rs12066569; rs35730992; rs2817892; rs34503312; rs12746187; rs5773022; rs35801029; rs12023962; rs34927145; rs41310408; rs4480326; rs11386948; rs3053666; rs10158017; rs12070853; rs34756320; rs34228242; rs35296875; rs12734389; rs12045243; rs35670137; rs35489986; rs7515300; rs34811855; rs12062913; rs12726813; rs6685103; rs35890332; rs34161880; rs10917326; rs28554002; rs35145214; rs874696; rs34942911; rs5773027; rs2493342; rs309469; rs12040097; rs34582528; rs10683795; rs12068351; rs35618079; rs12117711; rs10675382; rs2582034; rs35506920; rs28453916; rs34165268; rs12749566; rs12137587; rs12088757; rs2817880; rs6697383; rs34123232; rs36041857; rs4996341; rs5773018; rs34162616; rs12749445; rs35414054; rs12750256; rs11287437; rs34446692; rs10608016; rs5773023; rs4655122; rs10917302; rs2869057; rs34544278; rs12030428; rs10737468; rs10612497; rs12567110; rs28455953; rs34477804; rs35644005; rs6659910; rs35920905; rs35833273; rs12030616; rs36075209; rs35066330; rs12081762; rs34182895; rs2582024; rs34464314; rs2582028; rs6656394; rs2817891; rs7537713; rs12092809; rs309463; rs12120875; rs34062027; rs35358262; rs35219257; rs11361622; rs12747672; rs3032081; rs34956722; rs10917311; rs12409127; rs4654810; rs12045933; rs1866793; rs10442641; rs35606346; rs12066575; rs34256463; rs34500334; rs35046719; rs12744260; rs12759240; rs11420316; rs34902446; rs35262576; rs11800174; rs2675499; rs2817894; rs294217; rs294218; rs309490; rs309491; rs309492; rs309493; rs309494; rs309517; rs34957055; rs35520349; rs482273; rs6663671; rs6687402; rs744834; rs7520204; rs7555910

# Metabolic_Enzyme_4_General_References:
8589679; 9696046; 7898931; 7601466; 7688222; 1648701; 10508479; 9933164

# Metabolic_Enzyme_4_References:
12077486; 12535285; 15087176; 15111041

# Metabolic_Enzyme_5_ID:
7965

# Metabolic_Enzyme_5_Name:
Aldose reductase

# Metabolic_Enzyme_5_Synonyms:
AR; Aldehyde reductase

# Metabolic_Enzyme_5_Gene_Name:
AKR1B1

# Metabolic_Enzyme_5_Protein_Sequence:
>Aldose reductase
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF

# Metabolic_Enzyme_5_Number_of_Residues:
316

# Metabolic_Enzyme_5_Molecular_Weight:
35854

# Metabolic_Enzyme_5_Theoretical_pI:
6.99

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies

# Metabolic_Enzyme_5_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism

# Metabolic_Enzyme_5_Reaction:
alditol + NAD(P)+ = aldose + NAD(P)H + H+

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.1.1.21

# Metabolic_Enzyme_5_GenBank_ID_Protein:
178487

# Metabolic_Enzyme_5_SwissProt_ID:
ALDR_HUMAN (P15121)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
AKR1B1

# Metabolic_Enzyme_5_Geneatlas_id:
AKR1B1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:381

# Metabolic_Enzyme_5_PDB_ID:
1T40

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>951 bp
ATGGCAAGCCGTCTCCTGCTCAACAACGGCGCCAAGATGCCCATCCTGGGGTTGGGTACC
TGGAAGTCCCCTCCAGGGCAGGTGACTGAGGCCGTGAAGGTGGCCATTGACGTCGGGTAC
CGCCACATCGACTGTGCCCATGTGTACCAGAATGAGAATGAGGTGGGGGTGGCCATTCAG
GAGAAGCTCAGGGAGCAGGTGGTGAAGCGTGAGGAGCTCTTCATCGTCAGCAAGCTGTGG
TGCACGTACCATGAGAAGGGCCTGGTGAAAGGAGCCTGCCAGAAGACACTCAGCGACCTG
AAGCTGGACTACCTGGACCTCTACCTTATTCACTGGCCGACTGGCTTTAAGCCTGGGAAG
GAATTTTTCCCATTGGATGAGTCGGGCAATGTGGTTCCCAGTGACACCAACATTCTGGAC
ACGTGGGCGGCCATGGAAGAGCTGGTGGATGAAGGGCTGGTGAAAGCTATTGGCATCTCC
AACTTCAACCATCTCCAGGTGGAGATGATCTTAAACAAACCTGGCTTGAAGTATAAGCCT
GCAGTTAACCAGATTGAGTGCCACCCATATCTCACTCAGGAGAAGTTAATCCAGTACTGC
CAGTCCAAAGGCATCGTGGTGACCGCCTACAGCCCCCTCGGCTCTCCTGACAGGCCCTGG
GCCAAGCCCGAGGACCCTTCTCTCCTGGAGGATCCCAGGATCAAGGCGATCGCAGCCAAG
CACAATAAAACTACAGCCCAGGTCCTGATCCGGTTCCCCATGCAGAGGAACTTGGTGGTG
ATCCCCAAGTCTGTGACACCAGAACGCATTGCTGAGAACTTTAAGGTCTTTGACTTTGAA
CTGAGCAGCCAGGATATGACCACCTTACTCAGCTACAACAGGAACTGGAGGGTCTGTGCC
TTGTTGAGCTGTACCTCCCACAAGGATTACCCCTTCCATGAAGAGTTTTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
J04795

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_5_Locus:
7q35

# Metabolic_Enzyme_5_SNPs:
rs5054; rs5060; rs5059; rs2229543; rs3087630; rs5055; rs5053; rs1790999; rs1790998; rs1646640; rs4732027; rs2734653; rs3896278; rs2734650; rs10954455; rs1708432; rs10808275; rs17660462; rs2670227; rs11974100; rs2734657; rs2670232; rs1424426; rs2734649; rs2551472; rs2259458; rs17188118; rs12669537; rs2734655; rs7778371; rs1708434; rs11971263; rs2670230; rs10273906; rs17167854; rs2734665; rs969309; rs2701020; rs2734663; rs2734664; rs706207; rs759853; rs17167851; rs918825; rs918824; rs11975656; rs17856148; rs11544687; rs5057; rs4728325; rs5061; rs5062; rs5056; rs17849987; rs1803093; rs3210035; rs11544690; rs13306160; rs1803094; rs1803095; rs2852171; rs2854854; rs2551469; rs3749434; rs2734661; rs2670231; rs2551471; rs1791000; rs2670240; rs2734659; rs2852165; rs2551476; rs3216672; rs2854849; rs7801237; rs2269068; rs10588800; rs35880193; rs2734658; rs34559471; rs2691837; rs1732035; rs2852170; rs2854853; rs2670239; rs1646639; rs2854851; rs5058; rs2551470; rs2670233; rs13306159; rs2854848; rs2701019; rs2734660; rs1732037; rs2852164; rs11417418; rs35431624; rs2852163; rs2269069; rs35632302; rs2852173; rs2854850; rs2551473; rs35338055; rs2691840; rs2852172; rs2734652; rs2852167; rs2854852; rs6963238; rs1791006; rs34569487; rs2670229; rs2551475; rs2691838; rs13306161; rs3216673; rs2974975; rs2551474; rs34678793; rs2551467; rs33945153; rs2852169; rs2734656; rs2854846; rs2734651; rs2691839; rs2734662; rs2852166; rs2691841; rs2551468; rs2691835; rs2551477; rs2691836; rs13306162; rs1708427; rs2852168; rs2670226; rs1621922; rs2852174; rs2551465; rs2691845; rs2551466; rs918826; rs35706999; rs2852176; rs2691846; rs1708404; rs12532832; rs1732039; rs1646636; rs1646642; rs1646637; rs2852175; rs1646641; rs10228986; rs10236262; rs10236468; rs10241645; rs10244489; rs10252030; rs10263438; rs10275865; rs11973239; rs13225343; rs1708414; rs1708415; rs1708416; rs17167841; rs1722900; rs1722911; rs1732038; rs1791001; rs2347375; rs2670228; rs6977866; rs706206; rs7802421; rs782054

# Metabolic_Enzyme_5_General_References:
2498333; 2504709; 2510130; 2111143; 2112546; 1901857; 9195951; 8435445; 2492527; 8343525; 8281941; 8245005; 1621098; 1447221; 8234324; 9405046

# Metabolic_Enzyme_5_References:
10339620; 10733904; 11729242; 12482947

# Macromolecular_Interacting_Partner_1_ID:
5430

# Macromolecular_Interacting_Partner_1_Name:
Heme oxygenase 1

# Macromolecular_Interacting_Partner_1_Synonyms:
HO-1

# Macromolecular_Interacting_Partner_1_Gene_Name:
HMOX1

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Heme oxygenase 1
MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVA
LEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHE
VGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQ
LYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRA
SNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
288

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
32819

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
8.68

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  heme oxygenase (decyclizing) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  heterocycle metabolism
Process:  porphyrin metabolism
Process:  heme metabolism
Process:  heme oxidation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed

# Macromolecular_Interacting_Partner_1_Pathway:
map00860  Porphyrin and chlorophyll metabolism

# Macromolecular_Interacting_Partner_1_Reaction:
heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01126:Heme_oxygenase

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
265-287

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 1.14.99.3

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
35173

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
HMOX1_HUMAN (P09601)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
HMOX1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
HMOX1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:5013

# Macromolecular_Interacting_Partner_1_PDB_ID:
1T5P

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Microsome

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>867 bp
ATGGAGCGTCCGCAACCCGACAGCATGCCCCAGGATTTGTCAGAGGCCCTGAAGGAGGCC
ACCAAGGAGGTGCACACCCAGGCAGAGAATGCTGAGTTCATGAGGAACTTTCAGAAGGGC
CAGGTGACCCGAGACGGCTTCAAGCTGGTGATGGCCTCCCTGTACCACATCTATGTGGCC
CTGGAGGAGGAGATTGAGCGCAACAAGGAGAGCCCAGTCTTCGCCCCTGTCTACTTCCCA
GAAGAGCTGCACCGCAAGGCTGCCCTGGAGCAGGACCTGGCCTTCTGGTACGGGCCCCGC
TGGCAGGAGGTCATCCCCTACACACCAGCCATGCAGCGCTATGTGAAGCGGCTCCACGAG
GTGGGGCGCACAGAGCCCGAGCTGCTGGTGGCCCACGCCTACACCCGCTACCTGGGTGAC
CTGTCTGGGGGCCAGGTGCTCAAAAAGATTGCCCAGAAAGCCCTGGACCTGCCCAGCTCT
GGCGAGGGCCTGGCCTTCTTCACCTTCCCCAACATTGCCAGTGCCACCAAGTTCAAGCAG
CTCTACCGCTCCCGCATGAACTCCCTGGAGATGACTCCCGCAGTCAGGCAGAGGGTGATA
GAAGAGGCCAAGACTGCGTTCCTGCTCAACATCCAGCTCTTTGAGGAGTTGCAGGAGCTG
CTGACCCATGACACCAAGGACCAGAGCCCCTCACGGGCACCAGGGCTTCGCCAGCGGGCC
AGCAACAAAGTGCAAGATTCTGCCCCCGTGGAGACTCCCAGAGGGAAGCCCCCACTCAAC
ACCCGCTCCCAGGCTCCGCTTCTCCGATGGGTCCTTACACTCAGCTTTCTGGTGGCGACA
GTTGCTGTAGGGCTTTATGCCATGTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
X06985

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_1_Locus:
22q12|22q13.1

# Macromolecular_Interacting_Partner_1_SNPs:
rs2071747; rs9282702; rs5755713; rs11555832; rs9282701; rs8139532; rs8140370; rs5755720; rs5999815; rs8140669; rs11912889; rs6518952; rs9306300; rs5755719; rs3216831; rs9610292; rs5755718; rs2071748; rs17885185; rs5755717; rs2285112; rs5995100; rs2269533; rs11913097; rs5995099; rs17886055; rs16995662; rs5995097; rs7285877; rs2071749; rs2269534; rs17885522; rs12160711; rs17881086; rs5999816; rs17880614; rs2413346; rs4820192; rs8142390; rs17882597; rs17879082; rs5995098; rs9306301; rs5999814; rs9610291; rs9607267; rs5755716; rs17879606; rs11913209; rs17885902; rs17883018; rs5995101; rs9622194; rs17878790; rs17880294; rs17881147; rs17885925; rs2003038; rs17882565; rs2071746; rs9619536; rs3761439; rs17880288; rs12160039; rs17879895; rs5755712; rs17883752; rs9282700; rs35980144; rs11555830; rs11912348; rs17880056; rs5755721; rs36019273; rs35703925; rs36017314; rs35777199; rs5755715; rs17884268; rs13053677; rs17885296; rs12169444; rs12483783; rs17885538; rs28691814; rs9622192; rs12169485; rs35360540; rs17878771; rs34204969; rs35400739; rs13053402; rs9622193; rs17883936; rs34918147; rs34345283; rs17879027; rs9619539; rs9622191; rs10628026; rs12628401; rs17884230; rs34867836; rs13054865; rs13058638; rs17880184; rs5750104; rs36054326; rs35427263; rs9610290; rs3074372; rs35622428; rs9619534; rs35071398; rs5999811; rs5999813; rs5999810; rs9619537; rs9619535; rs34824930; rs13057211; rs5999812; rs17879594; rs12159977; rs1078979; rs12168789; rs12170872; rs2307334; rs2307335; rs2307337; rs3761438; rs4603883; rs4645726; rs4645729; rs4645731; rs4645741; rs4645742; rs4645746; rs4645747; rs5755722; rs5995096; rs5999817; rs5999819; rs713618; rs713688; rs713873; rs735266; rs735267; rs737777; rs743811; rs743813; rs743815; rs9306299; rs9619540

# Macromolecular_Interacting_Partner_1_General_References:
3345742; 10591208; 2911585; 2537723; 10467099

# Macromolecular_Interacting_Partner_1_References:
11368167

# Macromolecular_Interacting_Partner_2_ID:
6263

# Macromolecular_Interacting_Partner_2_Name:
Prostaglandin G/H synthase 2 precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Cyclooxygenase- 2; COX-2; Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; PHS II

# Macromolecular_Interacting_Partner_2_Gene_Name:
PTGS2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Prostaglandin G/H synthase 2 precursor
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPT
PNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNAD
YGYKSWEAFSNLSYYTRALPP
VPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQ
GSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGL
GHGVDLNHIYGETLARQRKLRLFKDGK
MKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGL
VPGLMMYATIWLREHN
RVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPE
LLFNK
QFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQ
IAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMS
AELEALYGDIDAVELY
PALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKP
STFGGEVGFQIINTASIQSLICNNVKG
CPFTSFSVPDPELIKTVTINASSSRSGLDDIN
PTVLLKERSTEL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
604

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
68997

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
7.41

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity

# Macromolecular_Interacting_Partner_2_Pathway:
map00590  Prostaglandin and leukotriene metabolism

# Macromolecular_Interacting_Partner_2_Reaction:
arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF03098:An_peroxidase;
PF00008:EGF

# Macromolecular_Interacting_Partner_2_Signals:
1-17

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
EC 1.14.99.1

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
291988

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
PGH2_HUMAN (P35354)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
PTGS2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
PTGS2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:9605

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Microsome; microsomal membrane; peripheral membrane protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1815 bp

ATGCTCGCCCGCGCCCTGCTGCTGTGCGCGGTCCTGGCGCTCAGCCATACAGCAAATCC
TTGCTGTTCCC
ACCCATGTCAAAACCGAGGTGTATGTATGAGTGTGGGATTTGACCAGT
ATAAGTGCGATTGTACCCGGAC
AGGATTCTATGGAGAAAACTGCTCAACACCGGAATTT
TTGACAAGAATAAAATTATTTCTGAAACCCACT
CCAAACACAGTGCACTACATACTTAC
CCACTTCAAGGGATTTTGGAACGTTGTGAATAACATTCCCTTCC
TTCGAAATGCAATTA
TGAGTTATGTGTTGACATCCAGATCACATTTGATTGACAGTCCACCAACTTACAA
TGCT
GACTATGGCTACAAAAGCTGGGAAGCCTTCTCTAACCTCTCCTATTATACTAGAGCCCTT
CCTCCT
GTGCCTGATGATTGCCCGACTCCCTTGGGTGTCAAAGGTAAAAAGCAGCTTCC
TGATTCAAATGAGATTG
TGGAAAAATTGCTTCTAAGAAGAAAGTTCATCCCTGATCCCC
AGGGCTCAAACATGATGTTTGCATTCTT
TGCCCAGCACTTCACGCATCAGTTTTTCAAG
ACAGATCATAAGCGAGGGCCAGCTTTCACCAACGGGCTG
GGCCATGGGGTGGACTTAAA
TCATATTTACGGTGAAACTCTGGCTAGACAGCGTAAACTGCGCCTTTTCA
AGGATGGAA
AAATGAAATATCAGATAATTGATGGAGAGATGTATCCTCCCACAGTCAAAGATACTCAGG
C
AGAGATGATCTACCCTCCTCAAGTCCCTGAGCATCTACGGTTTGCTGTGGGGCAGGAG
GTCTTTGGTCTG
GTGCCTGGTCTGATGATGTATGCCACAATCTGGCTGCGGGAACACAA
CAGAGTATGCGATGTGCTTAAAC
AGGAGCATCCTGAATGGGGTGATGAGCAGTTGTTCC
AGACAAGCAGGCTAATACTGATAGGAGAGACTAT
TAAGATTGTGATTGAAGATTATGTG
CAACACTTGAGTGGCTATCACTTCAAACTGAAATTTGACCCAGAA
CTACTTTTCAACAA
ACAATTCCAGTACCAAAATCGTATTGCTGCTGAATTTAACACCCTCTATCACTGGC
ATC
CCCTTCTGCCTGACACCTTTCAAATTCATGACCAGAAATACAACTATCAACAGTTTATCT
ACAACAA
CTCTATATTGCTGGAACATGGAATTACCCAGTTTGTTGAATCATTCACCAGG
CAAATTGCTGGCAGGGTT
GCTGGTGGTAGGAATGTTCCACCCGCAGTACAGAAAGTATC
ACAGGCTTCCACTGACCAGAGCAGGCAGA
TGAAATACCAGTCTTTTAATGAGTACCGCA
AACGCTTTATGCTGAAGCCCTATGAATCATTTGAAGAACT
TACAGGAGAAAAGGAAATG
TCTGCAGAGTTGGAAGCACTCTATGGTGACATCGATGCTGTGGAGCTGTAT
CCTGCCCT
TCTGGTAGAAAAGCCTCGGCCAGATGCCATCTTTGGTGAAACCATGGTAGAAGTTGGAGC
AC
CATTCTCCTTGAAAGGACTTATGGGTAATGTTATATGTTCTCCTGCCTACTGGAAGC
CAAGCACTTTTGG
TGGAGAAGTGGGTTTTCAAATCATCAACACTGCCTCAATTCAGTCT
CTCATCTGCAATAACGTGAAGGGC
TGTCCCTTTACTTCATTCAGTGTTCCAGATCCAGA
GCTCATTAAAACAGTCACCATCAATGCAAGTTCTT
CCCGCTCCGGACTAGATGATATCA
ATCCCACAGTACTACTAAAAGAACGTTCGACTGAACTGTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
L15326

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_2_Locus:
1q25.2-q25.3

# Macromolecular_Interacting_Partner_2_SNPs:
rs3218622; rs5272; rs5273; rs3218625; rs5279; rs5277; rs5278; rs5274; rs3218623; rs20429; rs4648265; rs5276; rs5275; rs2206593; rs4648292; rs689469; rs5271; rs3835508; rs689467; rs689470; rs689468; rs4648257; rs4648303; rs1051897; rs4648300; rs4648290; rs1051896; rs4648297; rs4648302; rs4648296; rs20432; rs2066826; rs4648268; rs4648287; rs20427; rs4648283; rs4648274; rs4648273; rs4648278; rs20430; rs4648284; rs20428; rs4648272; rs11567821; rs4648276; rs4648282; rs4648261; rs2745557; rs2066824; rs4648285; rs4648267; rs2066823; rs4648263; rs16825748; rs3218626; rs4648277; rs11567827; rs11567834; rs4648280; rs20434; rs2066822; rs4648271; rs4648262; rs4648258; rs16825745; rs20433; rs20424; rs4648306; rs20419; rs4648307; rs20415; rs4648308; rs689466; rs689465; rs20418; rs5270; rs4648251; rs4648256; rs4648304; rs4648310; rs20417; rs4648250; rs3918304; rs4648311; rs689462; rs20423; rs20420; rs2734779; rs11567815; rs11567831; rs11567814; rs4648309; rs20416; rs4648305; rs4648254; rs20426; rs4648279; rs4648264; rs4648288; rs3218624; rs3179567; rs4648295; rs36233646; rs3134592; rs3134591; rs4648299; rs4648298; rs13306032; rs11384450; rs11567830; rs13306038; rs3134589; rs13306033; rs2853804; rs3134590; rs2853805; rs11567829; rs11567819; rs4648289; rs4648301; rs13306035; rs34888870; rs4648294; rs13306031; rs4648293; rs2853803; rs4987012; rs12759220; rs11567822; rs4648260; rs4648269; rs11567826; rs13306034; rs4648259; rs11567820; rs4648266; rs11567825; rs4648281; rs11567824; rs11567823; rs4648286; rs4648270; rs4322189; rs35440347; rs11567835; rs689463; rs4648253; rs2223626; rs11567832; rs689464; rs20421; rs4648252; rs2745558; rs34901173; rs4648255; rs11567833; rs20422; rs11567837; rs11567836; rs12027712; rs10649972; rs10911902; rs10911905; rs10911907; rs10911908; rs1119064; rs1119065; rs11583191; rs12042763; rs12064238; rs12124257; rs12749248; rs2143416; rs2143417; rs2179555; rs2383515; rs2734776; rs2734777; rs2745559; rs4422959; rs6684912

# Macromolecular_Interacting_Partner_2_General_References:
8473346; 1380156; 8181472; 7945196

# Macromolecular_Interacting_Partner_2_References:
16282556; 8613062; 8764992

# Macromolecular_Interacting_Partner_3_ID:
7803

# Macromolecular_Interacting_Partner_3_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_3_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_3_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_3_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_3_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_3_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_3_SNPs:
Not Available

# Macromolecular_Interacting_Partner_3_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_3_References:
12231402; 8181468

# Macromolecular_Interacting_Partner_4_ID:
8319

# Macromolecular_Interacting_Partner_4_Name:
Sodium- and chloride-dependent GABA transporter 1

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC6A1

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Sodium and chloridedependent GABA transporter 1
MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLALKGSLKQRIQVMVQPSEDTVRPENGPEHAQAGSSTSKEAYI

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
599

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
67015

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.16

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
Function:  transporter activity
Function:  organic acid transporter activity
Function:  organic acid:sodium symporter activity
Function:  sodium:amino acid symporter activity
Function:  gamma-aminobutyric acid:sodium symporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
53-73
81-100
124-144
212-230
239-256
292-309
321-342
375-394
422-440
457-477
498-517
536-554

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
31658

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
SC6A1_HUMAN (P30531)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC6A1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC6A1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11042

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cell membrane; multi-pass membrane protein. Membrane; multi-pass membrane protein. Note=Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1800 bp
ATGGCGACCAACGGCAGCAAGGTGGCCGACGGGCAGATCTCCACCGAGGTCAGCGAGGCC
CCTGTGGCCAATGACAAGCCCAAAACCTTGGTGGTCAAGGTGCAGAAGAAGGCGGCAGAC
CTCCCCGACCGGGACACGTGGAAGGGCCGCTTCGACTTCCTCATGTCCTGTGTGGGCTAT
GCCATCGGCCTGGGCAACGTCTGGAGGTTCCCCTATCTCTGCGGGAAAAATGGTGGGGGA
GCCTTCCTGATCCCCTATTTCCTGACACTCATCTTTGCGGGGGTCCCACTCTTCCTGCTG
GAGTGCTCCCTGGGCCAGTACACCTCCATCGGGGGGCTAGGGGTATGGAAGCTGGCTCCT
ATGTTCAAGGGCGTGGGCCTTGCGGCTGCTGTGCTATCATTCTGGCTGAACATCTACTAC
ATCGTCATCATCTCCTGGGCCATTTACTACCTGTACAACTCCTTCACCACGACACTGCCG
TGGAAACAGTGCGACAACCCCTGGAACACAGACCGCTGCTTCTCCAACTACAGCATGGTC
AACACTACCAACATGACCAGCGCTGTGGTGGAGTTCTGGGAGCGCAACATGCATCAGATG
ACGGACGGGCTGGATAAGCCAGGTCAGATCCGCTGGCCACTGGCCATCACGCTGGCCATC
GCCTGGATCCTTGTGTATTTCTGTATCTGGAAGGGTGTTGGCTGGACTGGAAAGGTGGTC
TACTTTTCAGCCACATACCCCTACATCATGCTGATCATCCTGTTCTTCCGTGGAGTGACG
CTGCCCGGGGCCAAGGAGGGCATCCTCTTCTACATCACACCCAACTTCCGCAAGCTGTCT
GACTCCGAGGTGTGGCTGGATGCGGCAACCCAGATCTTCTTCTCATACGGGCTGGGCCTG
GGGTCCCTGATCGCTCTCGGGAGCTACAACTCTTTCCACAACAATGTCTACAGGGACTCC
ATCATCGTCTGCTGCATCAATTCGTGCACCAGCATGTTCGCAGGATTCGTCATCTTCTCC
ATCGTGGGCTTCATGGCCCATGTCACCAAGAGGTCCATTGCTGATGTGGCCGCCTCAGGC
CCCGGGCTGGCGTTCCTGGCATACCCAGAGGCGGTGACCCAGCTGCCTATCTCCCCACTC
TGGGCCATCCTCTTCTTCTCCATGCTGTTGATGCTGGGCATTGACAGCCAGTTCTGCACT
GTGGAGGGCTTCATCACAGCCCTGGTGGATGAGTACCCCAGGCTCCTCCGCAACCGCAGA
GAGCTCTTCATTGCTGCTGTCTGCATCATCTCCTACCTGATCGGTCTCTCTAACATCACT
CAGGGGGGTATTTATGTCTTCAAACTCTTTGACTACTACTCTGCCAGTGGCATGAGCCTG
CTGTTCCTCGTGTTCTTTGAATGTGTCTCTATTTCCTGGTTTTACGGTGTCAACCGATTC
TATGACAATATCCAAGAGATGGTTGGATCCAGGCCCTGCATCTGGTGGAAACTCTGCTGG
TCTTTCTTCACACCAATCATTGTGGCGGGCGTGTTCATTTTCAGTGCTGTGCAGATGACG
CCACTCACCATGGGAAACTATGTTTTCCCCAAGTGGGGCCAGGGTGTGGGCTGGCTGATG
GCTCTGTCTTCCATGGTCCTCATCCCCGGGTACATGGCCTACATGTTCCTCGCCCTAAAG
GGCTCCCTGAAGCAGCGCATCCAAGTCATGGTCCAGCCCAGCGAAGACACTGTTCGCCCA
GAGAATGGTCCTGAGCACGCCCAGGCGGGCAGCTCCACCAGCAAGGAGGCCTACATCTAG


# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
X54673

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_4_Locus:
3p25-p24

# Macromolecular_Interacting_Partner_4_SNPs:
rs2272404; rs33948309; rs6344; rs2272401; rs6343; rs1710887; rs2928079; rs1710891; rs2933308; rs2930154; rs2675166; rs2944367; rs1710898; rs2675165; rs1568074; rs720352; rs1062246; rs1710892; rs1170695; rs6766999; rs9863701; rs2933309; rs9855272; rs1728816; rs9821726; rs6778281; rs1710897; rs1710890; rs6780165; rs1728817; rs1728814; rs4684055; rs2601126; rs1710880; rs6442218; rs2933310; rs2950800; rs2697149; rs6766512; rs11707097; rs9821288; rs1919075; rs1728811; rs4684054; rs3732944; rs2675161; rs2697144; rs2675160; rs7613535; rs11718132; rs9990174; rs17466478; rs1728815; rs1728807; rs11710097; rs6342; rs1170694; rs1710881; rs1710886; rs11710497; rs2930138; rs2697146; rs17466644; rs2697142; rs41276505; rs17033824; rs1617523; rs7629093; rs1170696; rs2675159; rs6789420; rs6804165; rs2944366; rs13320265; rs1710885; rs2697145; rs1728806; rs7645218; rs2944365; rs11919775; rs2933311; rs1568073; rs17601884; rs17033808; rs34189945; rs2697148; rs6766500; rs2697150; rs2601125; rs2933307; rs4038396; rs9879137; rs3817585; rs2697136; rs17532365; rs3856786; rs2697135; rs1028152; rs3856787; rs6780064; rs9821628; rs2246543; rs11925331; rs2950798; rs11719645; rs2272403; rs9876005; rs1728803; rs11708202; rs9310373; rs2272402; rs6770472; rs2675163; rs1728802; rs10510403; rs1710888; rs9836017; rs9822125; rs17033838; rs2928077; rs11712912; rs17033829; rs10514669; rs2928078; rs3774070; rs2675164; rs2697134; rs3817584; rs11711646; rs9819882; rs11290120; rs6341; rs12107996; rs3841958; rs2697138; rs7643585; rs1728818; rs2675156; rs2928080; rs2067382; rs2675157; rs1400154; rs2928081; rs17855574; rs1139554; rs17853248; rs35513423; rs34201135; rs2675167; rs2933313; rs35456709; rs10696522; rs11425810; rs34389160; rs13076117; rs35265541; rs41293373; rs7431276; rs10710996; rs35119915; rs35964686; rs2675158; rs2077135; rs1062616; rs11710192; rs1062237; rs11280487; rs1568072; rs34884581; rs6766948; rs2933312; rs34937975; rs11706135; rs7650969; rs1105781; rs41429044; rs5846691; rs11319908; rs34458709; rs2077136; rs35997142; rs11923810; rs34408917; rs2930155; rs2601124; rs11319907; rs35743928; rs35862296; rs34236722; rs2944364; rs2204689; rs34990229; rs2930137; rs35322516; rs28562799; rs41362845; rs10711832; rs2697147; rs2944363; rs11288671; rs35849758; rs17033816; rs41510044; rs41293365; rs34530325; rs41391147; rs9869358; rs41517144; rs41497953; rs41444444; rs41293369; rs41422847; rs41381549; rs2697140; rs41370144; rs35486441; rs41293371; rs41426745; rs3774069; rs35910232; rs34536989; rs10702772; rs2928076; rs34939196; rs2697141; rs9878778; rs34279235; rs41506145; rs9827626; rs41308232; rs10663120; rs41537851; rs35855996; rs41388950; rs6799755; rs9825337; rs9874325; rs2697139; rs41486951; rs35518745; rs34543552; rs41386254; rs41276503; rs35731717; rs1710882; rs41436650; rs1710889; rs35278682; rs41293367; rs41524646; rs41478447; rs2697137; rs41323844; rs35244184; rs9874479; rs10662859; rs41335049; rs35504380; rs35994749; rs41480248; rs41342644; rs34428600; rs34937215; rs35296635; rs1710873; rs41338544; rs41469948; rs2697151; rs13092196; rs12019231; rs34317261; rs10470635; rs11719708; rs12185978; rs12186082; rs1400155; rs1630696; rs1710874; rs1710875; rs1710876; rs1710877; rs1710878; rs1710879; rs1728819; rs1728820; rs1728821; rs17467186; rs1919076; rs2343224; rs2928082; rs2930151; rs2930152; rs36034065; rs4282038; rs4572751; rs4684752; rs6794616; rs6794626; rs7650199; rs9682960; rs9814213; rs9844030

# Macromolecular_Interacting_Partner_4_General_References:
2387399

# Macromolecular_Interacting_Partner_4_References:
11049839; 11070414; 11380820; 15248296

# Macromolecular_Interacting_Partner_5_ID:
8198

# Macromolecular_Interacting_Partner_5_Name:
Sodium- and chloride-dependent betaine transporter

# Macromolecular_Interacting_Partner_5_Synonyms:
Na(+/Cl(-betaine/GABA transporter; BGT-1

# Macromolecular_Interacting_Partner_5_Gene_Name:
SLC6A12

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Sodium and chloridedependent betaine transporter
MDGKVAVQEYGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVW
RFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGL
ASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTP
FENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVY
FTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQG
CLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGP
GLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGR
RELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADR
FYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGW
FLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSP
TREGLIAGEKETHL

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
614

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
69429

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
Function:  transporter activity
Function:  organic acid transporter activity
Function:  organic acid:sodium symporter activity
Function:  sodium:amino acid symporter activity
Function:  gamma-aminobutyric acid:sodium symporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
45-65
73-92
117-137
211-229
238-255
291-308
320-341
374-393
423-441
458-478
499-518
538-556

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
881475

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
S6A12_HUMAN (P48065)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
SLC6A12

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
SLC6A12

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:11045

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1845 bp
ATGGACGGGAAGGTGGCAGTGCAAGAGCGTGGGCCTCCTGCGGTCTCCTGGGTCCCCGAG
GAGGGAGAGAAGTTGGACCAGGAAGACGAGGACCAGGTGAAGGATCGGGGCCAATGGACC
AACAAGATGGAGTTTGTGCTGTCAGTGGCCGGGGAGATCATTGGGCTGGGCAATGTCTGG
AGGTTTCCCTATCTCTGCTACAAAAACGGAGGTGGAGCCTTCTTCATCCCCTACTTCATC
TTCTTCTTTGTCTGCGGCATCCCGGTGTTCTTCCTGGAGGTGGCGTTGGGCCAATACACC
AGCCAAGGGAGTGTCACAGCCTGGAGGAAGATCTGCCCCCTCTTCCAGGGCATTGGTCTG
GCATCTGTGGTCATCGAGTCATATTTGAATGTCTACTACATCATCATCCTTGCCTGGGCT
CTCTTCTACCTGTTCAGCTCCTTCACTTCTGAGCTGCCCTGGACGACCTGCAACAACTTT
TGGAACACAGAGCATTGCACGGACTTTCTGAACCACTCAGGAGCCGGCACAGTGACCCCA
TTTGAGAATTTTACCTCACCTGTCATGGAATTCTGGGAGAGACGAGTTCTGGGCATCACC
TCGGGCATCCATGACCTGGGCTCCCTGCGCTGGGAGCTGGCCCTGTGCCTCCTGCTCGCC
TGGGTCATCTGCTATTTCTGCATCTGGAAGGGGGTCAAGTCCACAGGCAAGGTGGTTTAT
TTCACAGCCACGTTTCCGTACCTGATGCTTGTCATTTTGCTGATCAGAGGTGTCACCCTT
CCCGGAGCCTACCAGGGCATCATCTACTACTTGAAGCCAGATTTGTTCCGCCTCAAGGAC
CCTCAGGTGTGGATGGATGCGGGCACCCAGATCTTCTTCTCCTTTGCCATCTGCCAGGGG
TGCCTGACAGCCCTGGGCAGCTACAACAAGTATCACAACAACTGCTACAAGGACTGCATC
GCCCTCTGCTTCCTGAACAGTGCCACCAGCTTTGTGGCTGGGTTTGTTGTCTTCTCCATC
CTGGGCTTCATGTCCCAAGAGCAAGGGGTGCCCATTTCTGAAGTGGCCGAGTCAGGTCCT
GGGCTGGCCTTCATCGCCTTCCCCAAGGCTGTGACTATGATGCCCTTATCCCAGCTGTGG
TCCTGCCTGTTCTTTATCATGCTCATATTCCTAGGGCTGGACAGCCAGTTTGTCTGTGTG
GAGTGCCTGGTGACAGCCTCCATAGACATGTTCCCCAGGCAGCTCCGGAAGAGCGGGCGG
CGCGAGCTCCTCATCCTCACCATCGCCGTCATGTGCTACCTGATAGGGCTTTTCCTGGTC
ACCGAGGGCGGGATGTACATCTTCCAGCTGTTTGACTACTATGCTTCCAGTGGCATATGC
CTGCTGTTCCTGTCATTGTTTGAAGTGGTCTGCATAAGCTGGGTGTATGGGGCGGACCGT
TTCTATGACAACATTGAGGACATGATTGGCTACCGGCCATGGCCCCTGGTGAAGATCTCC
TGGCTCTTCCTGACCCCTGGACTTTGCCTGGCCACTTTCCTCTTCTCCTTGAGCAAGTAC
ACCCCCCTCAAGTACAACAACGTCTATGTGTACCCGCCCTGGGGATACTCCATTGGCTGG
TTCCTGGCTCTGTCCTCCATGGTCTGTGTCCCACTCTTCGTCGTCATCACCCTCCTGAAG
ACTCGGGGTCCTTTCAGGAAGCGTCTGCGTCACGTCATCACCCCTGACTCCAGTCTGCCA
CAGCCCAAGCAACATCCCTGCTTGGATGGCAGTGCTGGCCGGAACTTTGGGCCCTCCCCA
ACAAGGGAAGGACTGATAGCCGGGGAGAAGGAGACCCATTTGTAG

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
U27699

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_5_Locus:
12p13

# Macromolecular_Interacting_Partner_5_SNPs:
rs557881; rs216250; rs526690; rs188610; rs542736; rs1051104; rs2075228; rs16928441; rs499368; rs10848574; rs529395; rs1051102; rs530510; rs3759373; rs546465; rs2284329; rs522993; rs2284328; rs4980866; rs216243; rs216245; rs2284330; rs2072536; rs216244; rs797743; rs557930; rs2300127; rs646569; rs9783494; rs216242; rs216246; rs533572; rs4980865; rs797745; rs2300125; rs12318158; rs216252; rs11061978; rs188609; rs7303106; rs11061976; rs216248; rs4980863; rs216251; rs10773978; rs216255; rs2284331; rs216239; rs7967868; rs10848531; rs216241; rs216247; rs7303400; rs2300126; rs518685; rs216249; rs12424772; rs515932; rs495655; rs510714; rs10848520; rs7312189; rs12422447; rs7312186; rs11061915; rs11609900; rs629311; rs7138605; rs34185038; rs34265203; rs2075229; rs7135457; rs34701255; rs4994258; rs12311166; rs12298213; rs632325; rs12425688; rs10582500; rs34233015; rs4994259; rs10161151; rs2270337; rs7295053; rs35911251; rs12319731; rs10128942; rs11061911; rs3214377; rs3837517; rs12821712; rs34964706; rs9783527; rs12318264; rs35653444; rs3741968; rs4994257; rs216254; rs33929668; rs12315451; rs35671377; rs9783496; rs12367240; rs7315381; rs216253; rs35756516; rs216240; rs12816769; rs11836552; rs11061873; rs4994256; rs12308180; rs567487; rs584973; rs12302339; rs35708012; rs34988534; rs7306657; rs34042024; rs509877; rs35042967; rs10848483; rs11062011; rs216226; rs2289954; rs3847948; rs3890993; rs478455; rs478520; rs481219; rs495360; rs500844; rs502783; rs505387; rs529198; rs533112; rs558406; rs559759; rs570680; rs633159; rs647001; rs649277; rs797738; rs797739

# Macromolecular_Interacting_Partner_5_General_References:
7589472; 7861179

# Macromolecular_Interacting_Partner_5_References:
10400634; 10524210; 11380820; 12527556

# Macromolecular_Interacting_Partner_6_ID:
8262

# Macromolecular_Interacting_Partner_6_Name:
Sodium/myo-inositol cotransporter

# Macromolecular_Interacting_Partner_6_Synonyms:
Na(+/myo-inositol cotransporter

# Macromolecular_Interacting_Partner_6_Gene_Name:
SLC5A3

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Sodium/myoinositol cotransporter
MRAVLDTADIAIVALYFILVMCIGFFAMWKSNRSTVSGYFLAGRSMTWVTIGASLFVSNI
GSEHFIGLAGSGAASGFAVGAWEFNALLLLQLLGWVFIPIYIRSGVYTMPEYLSKRFGGH
RIQVYFAALSLILYIFTKLSVDLYSGALFIQESLGWNLYVSVILLIGMTALLTVTGGLVA
VIYTDTLQALLMIIGALTLMIISIMEIGGFEEVKRRYMLASPDVTSILLTYNLSNTNSCN
VSPKKEALKMLRNPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLAAKNIAHAKGSTL
MAGFLKLLPMFIIVVPGMISRILFTDDIACINPEHCMLVCGSRAGCSNIAYPRLVMKLVP
VGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYKLIRKSASSRELMIVGRIFVAFMVV
ISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFVL
GAVRLILAFAYRAPECDQPDNRPGFIKDIHYMYVATGLFWVTGLITVIVSLLTPPPTKEQ
IRTTTFWSKKNLVVKENCSPKEEPYQMQEKSILRCSENNETINHIIPNGKSEDSIKGLQP
EDVNLLVTCREEGNPVASLGHSEAETPVDAYSNGQAALMGEKERKKETDDGGRYWKFIDW
FCGFKSKSLSKRSLRDLMEEEAVCLQMLEETRQVKVILNIGLFAVCSLGIFMFVYFSL

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
718

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
79695

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
7.30

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00474:SSF

# Macromolecular_Interacting_Partner_6_Signals:
1-24

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
46253612

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
SC5A3_HUMAN (P53794)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SLC5A3

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SLC5A3

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:11038

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>2157 bp
ATGAGAGCTGTACTGGACACAGCAGACATTGCCATAGTGGCCCTGTATTTTATCCTGGTC
ATGTGCATTGGTTTTTTTGCCATGTGGAAATGTAATAGAAGCACCGTGAGTGGATACTTC
CTGGCGGGGCGCTCTATGACCTGGGTAGCAATTGGTGCCTCTCTGTTTGTGAGCAATATT
GGGAGTGAGCACTTCATTGGGCTGGCAGGATCTGGAGCTGCAAGTGGATTTGCAGTGGGC
GCATGGGAATTCAATGCCTTACTGCTTTTACAACTTCTGGGATGGGTTTTCATCCCAATT
TACATCCGGTCAGGGGTATATACCATGCCTGAATACTTGTCCAAGCGATTTGGTGGCCAT
AGGATTCAGGTCTATTTTGCAGCCTTGTCTCTGATTCTCTATATTTTCACCAAGCTCTCG
GTGGATCTGTATTCGGGTGCCCTTTTTATCCAGGAGTCTTTGGGTTGGAATCTTTATGTG
TCTGTCATCCTGCTCATTGGCATGACTGCTTTGCTGACTGTCACCGGAGGCCTTGTTGCA
GTGATCTACACAGACACTCTGCAGGCTCTGCTCATGATCATTGGGGCACTTACACTTATG
ATTATTAGCATAATGGAGATTGGCGGGTTTGAGGAAGTTAAGAGAAGGTACATGTTGGCC
TCACCCGATGTCACTTCCATCTTATTGACATACAACCTTTCCAACACAAATTCTTGTAAT
GTCTCCCCTAAGAAAGAAGCCCTGAAAATGCTGCGGAATCCAACAGATGAAGATGTTCCT
TGGCCTGGATTCATTCTTGGGCAGACCCCAGCTTCAGTATGGTACTGGTGTGCTGACCAA
GTCATCGTGCAGAGGGTCCTTGCAGCCAAAAACATTGCTCATGCCAAAGGCTCTACTCTT
ATGGCTGGCTTCTTAAAGCTCCTGCCAATGTTTATCATAGTTGTCCCAGGAATGATTTCC
AGGATACTGTTTACTGATGATATAGCTTGCATCAACCCAGAGCACTGCATGCTGGTGTGT
GGAAGCAGAGCTGGTTGCTCCAATATTGCTTACCCACGCCTGGTGATGAAGCTGGTTCCT
GTGGGCCTTCGGGGTTTAATGATGGCAGTGATGATTGCAGCTCTGATGAGTGACTTAGAC
TCTATCTTTAACAGTGCCAGTACCATATTCACCCTCGATGTGTACAAACTTATCCGCAAG
AGCGCAAGCTCCCGGGAGTTAATGATTGTGGGGAGGATATTTGTGGCATTTATGGTGGTG
ATCAGCATAGCATGGGTGCCAATCATCGTGGAGATGCAAGGAGGCCAGATGTACCTTTAC
ATTCAGGAGGTAGCAGATTACCTGACACCCCCAGTGGCAGCCTTGTTCCTGCTGGCAATT
TTCTGGAAGCGCTGCAATGAACAAGGGGCTTTCTATGGTGGAATGGCTGGCTTTGTTCTT
GGAGCAGTCCGTTTGATACTGGCCTTTGCCTACCGTGCCCCAGAATGTGACCAACCTGAT
AATAGGCCGGGCTTCATCAAAGACATCCATTATATGTATGTGGCCACAGGATTGTTTTGG
GTCACGGGACTCATTACTGTAATTGTGAGCCTTCTCACACCACCTCCCACAAAGGAACAG
ATTCGAACCACCACCTTTTGGTCTAAGAAGAACCTGGTGGTGAAGGAGAACTGCTCCCCA
AAAGAGGAACCATACAAAATGCAAGAAAAGAGCATTCTGAGATGCAGTGAGAATAATGAG
ACCATCAACCACATCATTCCCAACGGGAAATCTGAAGACAGCATTAAGGGCCTTCAGCCT
GAAGATGTTAATCTGTTGGTAACCTGCAGAGAGGAGGGCAACCCAGTGGCATCCTTAGGT
CATTCAGAGGCAGAAACACCAGTTGACGCTTACTCCAATGGGCAAGCAGCTCTCATGGGT
GAGAAAGAGAGAAAGAAAGAAACGGATGATGGAGGTCGGTACTGGAAGTTCATAGACTGG
TTTTGTGGCTTTAAAAGTAAGAGCCTCAGCAAGAGGAGTCTCAGAGACCTGATGGAAGAG
GAGGCTGTTTGTTTACAGATGCTAGAAGAGACTCGGCAAGTTAAAGTAATACTAAATATT
GGACTTTTTGCTGTGTGTTCACTTGGAATTTTCATGTTTGTTTATTTCTCCTTATGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
L38500

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_6_Locus:
Not Available

# Macromolecular_Interacting_Partner_6_SNPs:
Not Available

# Macromolecular_Interacting_Partner_6_General_References:
7789985; 9441750; 10830953

# Macromolecular_Interacting_Partner_6_References:
10051678; 8550845; 9633613

# Macromolecular_Interacting_Partner_7_ID:
8745

# Macromolecular_Interacting_Partner_7_Name:
CDNA FLJ20001 fis, clone ADKA01273

# Macromolecular_Interacting_Partner_7_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>CDNA FLJ20001 fis, clone ADKA01273
MEFLRAGSNVMQTFTFSASEDNMESKWEDVNAAACDLAREVAGKGDALVAGGICQTSIYK
YQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRPVAVTMCIGP
EGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPL
GFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRA
IAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSK
PDF

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
303

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
33907

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
5.28

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  S-methyltransferase activity
Function:  homocysteine S-methyltransferase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_7_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF02574:S-methyl_trans

# Macromolecular_Interacting_Partner_7_Signals:
Not Available

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
7019812

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
Q9NXX7_HUMAN (Q9NXX7)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
BHMT2

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
BHMT2

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:1048

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>912 bp
ATGGAATTCTTGAGAGCAGGATCAAATGTCATGCAGACTTTTACCTTTTCTGCCAGTGAG
GACAATATGGAAAGCAAGTGGGAAGATGTAAATGCTGCTGCCTGTGACCTCGCCAGGGAA
GTGGCTGGCAAAGGTGATGCTTTGGTAGCAGGGGGGATCTGCCAGACATCAATATACAAA
TACCAGAAGGATGAAGCTAGAATTAAAAAACTTTTTCGACAACAGCTAGAAGTTTTTGCC
TGGAAAAATGTGGACTTCTTGATTGCAGAGTATTTTGAGCACGTTGAAGAAGCTGTGTGG
GCTGTGGAAGTCTTAAAAGAATCAGATAGACCCGTGGCAGTTACCATGTGCATAGGCCCA
GAGGGAGACATGCATGATATAACCCCCGGAGAATGTGCTGTGAGGCTGGTGAAGGCAGGG
GCTTCCATCGTTGGCGTGAACTGCCGCTTTGGGCCCGACACCAGCTTGAAGACGATGGAG
CTCATGAAGGAGGGTCTTGAGTGGGCAGGGCTGAAAGCGCACCTCATGGTGCAGCCTCTG
GGGTTCCACGCGCCTGACTGTGGCAAAGAGGGGTTTGTGGATCTCCCAGAATATCCCTTT
GGACTGGAGTCCAGAGTTGCCACCAGATGGGATATTCAAAAATACGCCAGAGAGGCCTAC
AACCTGGGGGTCAGGTACATTGGCGGGTGCTGTGGATTTGAGCCCTACCACATCAGGGCA
ATTGCAGAGGAGCTGGCCCCAGAAAGGGGCTTTTTGCCACCAGCTTCAGAAAAACACGGC
AGCTGGGGAAGTGGTTTGGACATGCACACCAAACCCTGGATTAGAGCAAGGGCTCGAAGG
GAGTATTGGGAGAATCTGCTGCCAGCTTCAGGCAGACCTTTCTGTCCTTCGCTGTCAAAG
CCAGACTTCTAA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
AK000008

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Locus:
Not Available

# Macromolecular_Interacting_Partner_7_SNPs:
Not Available

# Macromolecular_Interacting_Partner_7_General_References:
Not Available

# Macromolecular_Interacting_Partner_7_References:
Not Available

End of HMDB00043

Beginning of HMDB00044
# Accession_No:
HMDB00044

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-09 11:56:06

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Ascorbic acid

# Description:
Ascorbic acid is an essential nutrient in human diets, and is necessary to maintain connective tissue and bone. Its biologically active form is vitamin C. Primates (including humans) and a few other species in all divisions of the animal kingdom, notably the guinea pig, have lost the ability to synthesize ascorbic acid and must obtain it in their food.  Ascorbic acid is an electron donor for enzymes involved in collagen hydroxylation, biosynthesis of carnitine and norepinephrine, tyrosine metabolism, and amidation of peptide hormones; its deficiency causes scurvy. The amount of vitamin C necessary to prevent scurvy may not be adequate to maintain optimal health. The ability of vitamin C to donate electrons also makes it a potent water-soluble antioxidant that readily scavenges free radicals such as molecular oxygen, superoxide, hydroxyl radical, and hypochlorous acid. In this setting, several mechanisms could account for a link between vitamin C and heart disease. One is the relation between LDL oxidation and vitamins C and E. Vitamin C in vitro can recycle vitamin E, which can donate electrons to prevent LDL oxidation in vitro. As the lipid-phase vitamin E is oxidized, it can be regenerated by aqueous vitamin C. Other possibilities are that vitamin C could decrease cholesterol by mechanisms not well characterized, or could improve vasodilatation and vascular reactivity, perhaps by decreasing the interactions of nitric oxide with oxidants. (PMID 10799361)

# Synonyms:
(+)-ascorbate; (+)-ascorbic acid; 3-Keto-L-gulofuranolactone; 3-Oxo-L-gulofuranolactone; AA; Adenex; Allercorb; Antiscorbic vitamin; Antiscorbutic vitamin; Arco-cee; Ascoltin; Ascor-B.I.D.; Ascorb; Ascorbajen; Ascorbate; Ascorbic acid; Ascorbicab; Ascorbicap; Ascorbicin; Ascorbin; Ascorbutina; Ascorin; Ascorteal; Ascorvit; C-level; C-long; C-quin; C-span; C-vimin; Cantan; Cantaxin; Catavin C; Ce lent; Ce-mi-lin; Ce-vi-sol; Cebicure; Cebid; Cebion; Cebione; Cecon; Cee-caps TD; Cee-vite; Cegiolan; Ceglion; Ceklin; Celaskon; Celin; Cell C; Cemagyl; Cemill; Cenetone; Cenolate; Cereon; Cergona; Cescorbat; Cetamid; Cetane; Cetane-caps TC; Cetane-caps TD; Cetebe; Cetemican; Cevalin; Cevatine; Cevex; Cevi-bid; Cevimin; Cevital; Cevitamate; Cevitamic acid; Cevitamin; Cevitan; Cevitex; Cewin; Chewcee; Ciamin; Cipca; Citriscorb; Citrovit; Colascor; Concemin; Davitamon C; Dora-C-500; Duoscorb; Ferrous ascorbate; HiCee; Hybrin; Ido-C; Juvamine; Kangbingfeng; Kyselina askorbova; L(+)-ascorbate; L(+)-ascorbic acid; L-(+)-ascorbate; L-(+)-ascorbic acid; L-3-Ketothreohexuronic acid lactone; L-Ascorbic acid; L-ascorbate; L-lyxoascorbate; L-lyxoascorbic acid; L-threo-ascorbic acid; L-xyloascorbate; L-xyloascorbic acid; Laroscorbine; Lemascorb; Liqui-cee; Meri-c; Natrascorb; Natrascorb injectable; Planavit C; Proscorbin; Redoxon; Ribena; Ronotec 100; Rontex 100; Roscorbic; Rovimix C; Scorbacid; Scorbu C; Scorbu-C; Secorbate; Sodascorbate; Suncoat VC 40; Testascorbic; VASC; Vicelat; Vicin; Vicomin C; Viforcit; Viscorin; Viscorin 100M; Vitace; Vitacee; Vitacimin; Vitacin; Vitamin C; Vitamisin; Vitascorbol; Xitix; gamma-lactone L-threo-Hex-2-enonate; gamma-lactone L-threo-Hex-2-enonic acid; (+)-Sodium L-ascorbate 

# Chemical_IUPAC_Name:
(2S)-2-[(1R)-1,2-dihydroxyethyl]-4,5-dihydroxy-furan-3-one

# Chemical_Formula:
C6H8O6

# Chemical_Structure:
tbl_chemical:::HMDB00044_ZOOM.png:::119283152112449081

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00044_THUMB.png:::119283151919155272

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Vitamins

# Taxonomy_Family:
Food Additive

# Taxonomy_Species:
1,2-diol; heterocyclic compound; ketone; primary alcohol; secondary alcohol

# Taxonomy_Biofunction:
Essential vitamins; Anti-oxidant; Enzyme co-factor; Component of Tyrosine metabolism

# Taxonomy_Source:
Exogenous

# Molecular_Weight:
176.03209

# Molecular_Weight_Avg:
176.12411

# Smiles_String_isomeric:
OC[C@@H](O)[C@@H]1OC(O)=C(O)C1=O

# Smiles_String_canonical:
OCC(O)C1OC(O)=C(O)C1=O

# KEGG_Compound_ID:
C00072

# BioCyc_ID:
ASCORBATE

# PubChem_CID:
644104

# PubChem_SID:
15971359; 3372; 841571

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
33747

# Wikipedia_ID:
Ascorbic acid

# METLIN_ID:
3753

# Ref_ID:
1529283; 11978879; 7711198; 11984597; 15917019; 15190049; 2026685; 16425787; 15925292; 15640471; 16725131; 11805243; 16872308; 8726814; 12180551; 8467348; 16611389; 10920885; 16522902

# ChEBI_ID:
29073

# CAS_Registry_Number:
50-81-7

# InChI:
InChI=1/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-8,10-11H,1H2/t2-,5+/m1/s1

# Synthesis_Reference:
Not Available

# Melting_Point:
191 oC

# Melting_Point_predicted:
93.4 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
400 mg/mL at 40 oC [MERCK INDEX (1996)]

# H2O_Solubility_Predicted:
257.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-1.85 [AVDEEF,A (1997)]

# LogP_predicted:
-0.5 [Predicted by PubChem via XLOGP]; -1.86 [Predicted by ALOGPS]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::1165972662.html:::119922412670520>>>tbl_chemical:::1165972521.pdf:::181994583902466

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::1165972667.mol:::220767058971676

# SDF_File_[Text]:
tbl_chemical:::HMDB00044.sdf:::119283151506633936

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00044.pdb:::119283151745911924

# PDB_ID:
1E71

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041006_P00_03_HW_1DP_PRESAT_expanded_2.gif:::114460751565281319

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041006_P00_03_HW_1DP_presat.zip:::1175124395811910950

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041006_P00_03_HW_1DP_Assigned.png:::118045649283220794

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041006_P00_03_HW_1DP_presat.png:::114857302878585889

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041006_P00_03_HW_1DP_presat.zip:::114857422569317711

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041006_P00_03_HW_2DHSQC_684.png:::114789845502657772

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041006_P00_03_HW_2DHSQC_684.zip:::114789845507845484

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041006_P00_03_HW_2DHSQC_684_Assigned.png:::115083184638692848

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Ascorbic acid.gif:::1132732102250142987

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00044_peaks.txt:::1156309508028431139

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Ascorbic acid_C.gif:::1132737666350346925

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00044_peaks.txt:::1156310699632397897

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00044L.png:::11755526205815134; Medium Energy:tbl_ms:::HMDB00044M.png:::117555267123411632; High Energy:tbl_ms:::HMDB00044H.png:::117555271008459939

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000182.png:::116907444473492105

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000182.txt:::116907444471835399

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000182.png:::116890830384352293

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000182.txt:::116890830409321134

# Cellular_Location:
Cytoplasm; Extracellular

# Tissue_Location:
Adipose Tissue; Adrenal Cortex; Adrenal Medulla; Bladder; Brain; Epidermis; Erythrocyte; Eye Lens; Fibroblasts; Gonads; Heart; Intestine; Liver; Lung; Lymphocyte; Most Tissues; Muscle; Myelin; Neurons; Placenta; Platelet; Prostate; Skeletal Muscle; Spleen

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Cellular Cytoplasm; Urine

# Concentration_[Normal]:
Urine	63.6 +/-142.9	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	2026685
Blood	88.6 (21.0 - 171.0)	umol/L	Children:1-13_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 132. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	60.8 +/- 15.9	umol/L	Adult:>18_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 132. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	51.0 (11.0 - 125.0)	umol/L	Newborn:0-30_days_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 132. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	34.0 (0 - 85.0)	umol/L	Children:1-13_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 132. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	36.0 +/- 18.0	uM	Adult:>18_yrs_old	Both	Normal	15640471
Blood	63.0 (11.0-114.0)	umol/L	Adult:>18_yrs_old	Both	Normal	Merck Manual
Blood	22.2 (14.0-40.0)	uM	Adult:>18_yrs_old	Both	Normal	16522902
Cerebrospinal_Fluid(CSF)	68.0 (17.0-119.0)	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	163.8 +/- 21	umol/L	Adult:>18_yrs_old	N/A	Normal	11978879
Cerebrospinal_Fluid(CSF)	164.0 (143.0-185.0)	uM	Adult:>18_yrs_old	Both	Normal	11978879
Cerebrospinal_Fluid(CSF)	144.0 (36.2-251.0)	umol/L	Adult:>18_yrs_old	Both	Normal	11805243
Cellular_Cytoplasm	68.0 +/- 43.0	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 132. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.


# Concentration_[Abnormal]:
Cerebrospinal_Fluid(CSF)	53.8 (45.8-61.8)	umol/L	Adult:>18_yrs_old	Both	Pediatric traumatic brain injury	11978879
Cerebrospinal_Fluid(CSF)	11.9 (0.0-24)	umol/L	Adult:>18_yrs_old	Both	Bacterial meningitis	11805243


# Associated_Disorders:
Antidiuresis; Bacterial meningitis; Cardiovascular Disease; Charcot-Marie-Tooth Disease; Iron Deficiency; Pediatric traumatic brain injury; Scurvy; Steoporosis; Uroporphyria

# Pathway_Names:
Lysine degradation

# Pathway_Images:
Lysine_degradation.jpg

# KEGG_Images:
map00310

# Pathway_Graphs:
Lysine_degradation_Graph.jpg

# Pathway_SBMLs:
Lysine_degradation.xml

# Metabolic_Enzyme_1_ID:
5700

# Metabolic_Enzyme_1_Name:
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 precursor

# Metabolic_Enzyme_1_Synonyms:
Lysyl hydroxylase 2; LH2

# Metabolic_Enzyme_1_Gene_Name:
PLOD2

# Metabolic_Enzyme_1_Protein_Sequence:
>Procollagenlysine,2oxoglutarate 5dioxygenase 2 precursor
MGGCTVKPQLLLLALVLHPWNPCLGADSEKPSSIPTDKLLVITVATKESDGFHRFMQSAK
YFNYTVKVLGQGEEWRGGDGINSIGGGQKVRLMKEVMEHYADQDDLVVMFTECFDVIFAG
GPEEVLKKFQKANHKVVFAADGILWPDKRLADKYPVVHIGKRYLNSGGFIGYAPYVNRIV
QQWNLQDNDDDQLFYTKVYIDPLKREAINITLDHKCKIFQTLNGAVDEVVLKFENGKARA
KNTFYETLPVAINGNGPTKILLNYFGNYVPNSWTQDNGCTLCEFDTVDLSAVDVHPNVSI
GVFIEQPTPFLPRFLDILLTLDYPKEALKLFIHNKEVYHEKDIKVFFDKAKHEIKTIKIV
GPEENLSQAEARNMGMDFCRQDEKCDYYFSVDADVVLTNPRTLKILIEQNRKIIAPLVTR
HGKLWSNFWGALSPDGYYARSEDYVDIVQGNRVGVWNVPYMANVYLIKGKTLRSEMNERN
YFVRDKLDPDMALCRNAREMGVFMYISNRHEFGRLLSTANYNTSHYNNDLWQIFENPVDW
KEKYINRDYSKIFTENIVEQPCPDVFWFPIFSEKACDELVEEMEHYGKWSGGKHHDSRIS
GGYENVPTDDIHMKQVDLENVWLHFIREFIAPVTLKVFAGYYTKGFALLNFVVKYSPERQ
RSLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIESPRKGWSFMHPGRLTHLHEG
LPVKNGTRYIAVSFIDP

# Metabolic_Enzyme_1_Number_of_Residues:
737

# Metabolic_Enzyme_1_Molecular_Weight:
84686

# Metabolic_Enzyme_1_Theoretical_pI:
6.69

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  procollagen-lysine 5-dioxygenase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  endoplasmic reticulum

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links

# Metabolic_Enzyme_1_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_1_Reaction:
procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF03171:2OG-FeII_Oxy

# Metabolic_Enzyme_1_Signals:
1-25

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.14.11.4

# Metabolic_Enzyme_1_GenBank_ID_Protein:
2138314

# Metabolic_Enzyme_1_SwissProt_ID:
PLOD2_HUMAN (O00469)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
PLOD2

# Metabolic_Enzyme_1_Geneatlas_id:
PLOD2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:9082

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Endoplasmic reticulum; rough endoplasmic reticulum; rough endoplasmic reticulum membrane; peripheral membrane protein; lumenal side

# Metabolic_Enzyme_1_Gene_Sequence:
>2214 bp
ATGGGGGGATGCACGGTGAAGCCTCAGCTGCTGCTCCTGGCGCTCGTCCTCCACCCCTGG
AATCCCTGTCTGGGTGCGGACTCGGAGAAGCCCTCGAGCATCCCCACAGATAAATTATTA
GTCATAACTGTAGCAACAAAAGAAAGTGATGGATTCCATCGATTTATGCAGTCAGCCAAA
TATTTCAATTATACTGTGAAGGTCCTTGGTCAAGGAGAAGAATGGAGAGGTGGTGATGGA
ATTAATAGTATTGGAGGGGGCCAGAAAGTGAGATTAATGAAAGAAGTCATGGAACACTAT
GCTGATCAAGATGATCTGGTTGTCATGTTTACTGAATGCTTTGATGTCATATTTGCTGGT
GGTCCAGAAGAAGTTCTAAAAAAATTCCAAAAGGCAAACCACAAAGTGGTCTTTGCAGCA
GATGGAATTTTGTGGCCAGATAAAAGACTAGCAGACAAGTATCCTGTTGTGCACATTGGG
AAACGCTATCTGAATTCAGGAGGATTTATTGGCTATGCTCCATATGTCAACCGTATAGTT
CAACAATGGAATCTCCAGGATAATGATGATGATCAGCTCTTTTACACTAAAGTTTACATT
GATCCACTGAAAAGGGAAGCTATTAACATCACATTGGATCACAAATGCAAAATTTTCCAG
ACCTTAAATGGAGCTGTAGATGAAGTTGTTTTAAAATTTGAAAATGGCAAAGCCAGAGCT
AAGAATACATTTTATGAAACATTACCAGTGGCAATTAATGGAAATGGACCCACCAAGATT
CTCCTGAATTATTTTGGAAACTATGTACCCAATTCATGGACACAGGATAATGGCTGCACT
CTTTGTGAATTCGATACAGTCGACTTGTCTGCAGTAGATGTCCATCCAAACGTATCAATA
GGTGTTTTTATTGAGCAACCAACCCCTTTTCTACCTCGGTTTCTGGACATATTGTTGACA
CTGGATTACCCAAAAGAAGCACTTAAACTTTTTATTCATAACAAAGAAGTTTATCATGAA
AAGGACATCAAGGTATTTTTTGATAAAGCTAAGCATGAAATCAAAACTATAAAAATAGTA
GGACCAGAAGAAAATCTAAGTCAAGCGGAAGCCAGAAACATGGGAATGGACTTTTGCCGT
CAGGATGAAAAGTGTGATTATTACTTTAGTGTGGATGCAGATGTTGTTTTGACAAATCCA
AGGACTTTAAAAATTTTGATTGAACAAAACAGAAAGATCATTGCTCCTCTTGTAACTCGT
CATGGAAAGCTGTGGTCCAATTTCTGGGGAGCATTGAGTCCTGATGGATACTATGCACGA
TCTGAAGATTATGTGGATATTGTTCAAGGGAATAGAGTAGGAGTATGGAATGTCCCATAT
ATGGCTAATGTGTACTTAATTAAAGGAAAGACACTCCGATCAGAGATGAATGAAAGGAAC
TATTTTGTTCGTGATAAACTGGATCCTGATATGGCTCTTTGCCGAAATGCTAGAGAAATG
GGTGTATTTATGTACATTTCTAATAGACATGAATTTGGAAGGCTATTATCCACTGCTAAT
TACAATACTTCCCATTATAACAATGACCTCTGGCAGATTTTTGAAAATCCTGTGGACTGG
AAGGAAAAGTATATAAACCGTGATTATTCAAAGATTTTCACTGAAAATATAGTTGAACAG
CCCTGTCCAGATGTCTTTTGGTTCCCCATATTTTCTGAAAAAGCCTGTGATGAATTGGTA
GAAGAAATGGAACATTACGGCAAATGGTCTGGGGGAAAACATCATGATAGCCGTATATCT
GGTGGTTATGAAAATGTCCCAACTGATGATATCCACATGAAGCAAGTTGATCTGGAGAAT
GTATGGCTTGATTTTATCCGGGAGTTCATTGCACCAGTTACACTGAAGGTCTTTGCAGGC
TATTATACGAAGGGATTTGCACTACTGAATTTTGTAGTAAAATACTCCCCTGAACGACAG
CGTTCTCTTCGTCCTCATCATGATGCTTCTACATTTACCATAAACATTGCACTTAATAAC
GTGGGAGAAGACTTTCAGGGAGGTGGTTGCAAATTTCTAAGGTACAATTGCTCTATTGAG
TCACCACGAAAAGGCTGGAGCTTCATGCATCCTGGGAGACTCACACATTTGCATGAAGGA
CTTCCTGTTAAAAATGGAACAAGATACATTGCAGTGTCATTTATAGATCCCTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U84573

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_1_Locus:
3q23-q24

# Metabolic_Enzyme_1_SNPs:
rs6710; rs1707469; rs1868541; rs959329; rs1170389; rs764755; rs1170391; rs10935606; rs1900926; rs4681299; rs1170388; rs1375591; rs7642940; rs6440417; rs1449444; rs3816399; rs965032; rs1707465; rs3792341; rs1170393; rs1349215; rs3804669; rs9852725; rs1170390; rs9289718; rs6802384; rs6801418; rs12496198; rs3804661; rs7613150; rs1349214; rs4681297; rs2029137; rs3792340; rs11718741; rs7614409; rs6783601; rs1707473; rs2864794; rs9289713; rs1512901; rs1512900; rs9289715; rs9865802; rs6800434; rs9836725; rs10935608; rs10935601; rs1449441; rs4681301; rs9862237; rs1375585; rs3762690; rs3804666; rs4681112; rs1375587; rs3792345; rs3762694; rs6793380; rs9878166; rs1707471; rs3804664; rs10935605; rs7639592; rs1613796; rs2864793; rs9842036; rs1375581; rs3804660; rs9877411; rs4681298; rs6783926; rs895930; rs9289716; rs9858095; rs10935604; rs9852153; rs7431590; rs10935607; rs9813047; rs9820945; rs3804665; rs1562699; rs9809099; rs12496358; rs12498084; rs3804663; rs4681300; rs3762691; rs9289717; rs895929; rs6799720; rs6787625; rs1170392; rs1375582; rs12695808; rs3804659; rs1375588; rs1449450; rs3792339; rs2669396; rs9289714; rs3804668; rs6787634; rs4681294; rs1375584; rs4681111; rs1449443; rs7650527; rs7628412; rs963591; rs1868540; rs6440415; rs9881251; rs7650652; rs1868539; rs9869137; rs12632001; rs11919284; rs16857897; rs2864792; rs9822426; rs10935603; rs11717610; rs16857900; rs12492656; rs1449451; rs1449440; rs9842560; rs6440420; rs2029138; rs17413767; rs9828112; rs6781300; rs6440419; rs12495057; rs6793224; rs11914531; rs3828381; rs3804667; rs1613698; rs1375583; rs4681113; rs1982381; rs9836521; rs16857938; rs7628210; rs9842865; rs17412259; rs7641322; rs895928; rs16857916; rs1707472; rs7628222; rs9881772; rs1449442; rs1982382; rs9823126; rs9811822; rs1707479; rs2864795; rs9874388; rs2067375; rs4681295; rs7626859; rs9840602; rs9882583; rs7617913; rs3804670; rs6800294; rs6780480; rs6440418; rs1707466; rs3840209; rs11927032; rs2305274; rs16857919; rs1375589; rs4611785; rs9289712; rs7613937; rs1063157; rs1061261; rs34957134; rs34042812; rs13079521; rs1061262; rs34991720; rs34009978; rs34741228; rs34640052; rs34540779; rs3792347; rs34708378; rs1061260; rs35029247; rs35160202; rs34335756; rs34341243; rs34636181; rs33983488; rs35302944; rs11337357; rs34056190; rs13094630; rs35704675; rs10663177; rs28451909; rs35520151; rs7619272; rs35706246; rs5853263; rs34232127; rs1900929; rs2197908; rs9880704; rs9856304; rs35461076; rs13074471; rs11457807; rs13094640; rs35692942; rs34803917; rs34092280; rs13094892; rs4681296; rs34298175; rs10703593; rs34588668; rs13063652; rs3059069; rs5853265; rs11456176; rs34509746; rs13088659; rs28648696; rs35941599; rs13088180; rs10576552; rs13094632; rs11458112; rs35299945; rs7652622; rs13095083; rs35030961; rs34302224; rs3804662; rs10622187; rs12171294; rs10621402; rs36037345; rs13067100; rs11420653; rs11456231; rs12485544; rs35687630; rs9862265; rs11456819; rs34551842; rs13094655; rs10663152; rs11425603; rs34382856; rs34798280; rs13092649; rs35140877; rs1375580; rs35607678; rs11360876; rs3838608; rs10704713; rs35399797; rs9858081; rs35125036; rs34255485; rs34143458; rs1530742; rs35821615; rs2669397; rs34735927; rs34940478; rs12494929; rs34592151; rs34240070; rs3840208; rs11927021; rs7639115; rs6148118; rs34898407; rs11328609; rs35069585; rs34528837; rs35104103; rs11425393; rs5853262; rs10663012; rs34054457; rs10672417; rs13095103; rs35423942; rs7649967; rs36193485; rs35017529; rs34106207; rs1707468; rs36168881; rs16857921; rs35399421; rs1900928; rs2197907; rs34589717; rs13088158; rs34955707; rs5853266; rs4681293; rs3975816; rs13075266; rs11336772; rs28560023; rs34589948; rs35587646; rs34738950; rs13075648; rs13063887; rs11425913; rs34661470; rs13327204; rs5853264; rs35329274; rs36160119; rs35961312; rs34092722; rs4290778; rs34177874; rs1375586; rs1562700; rs35973610; rs1982383; rs35762539; rs13095139; rs12171307; rs35683071; rs35208268; rs6794727; rs34715073; rs34695557; rs35893777; rs11456175; rs35080774; rs13066226; rs11425298; rs36070925; rs34390384; rs35880309; rs36090265; rs13093088; rs35274473; rs11435306; rs10620863; rs35766352; rs965031; rs35597003; rs10620702; rs35401598; rs1530741; rs35512942; rs34708065; rs35748974; rs13096811; rs3059043; rs10935602; rs35252566; rs9843118; rs3842573; rs34075030; rs34392701; rs35899444; rs10619980; rs6775684; rs34383803; rs35532167; rs921272; rs34722039; rs34901222; rs35969739; rs34464230; rs34717183; rs35269237; rs34471669; rs34583562; rs11721146; rs11916662; rs11917712; rs11917774; rs11917816; rs11919826; rs11923433; rs11925421; rs13087364; rs1375590; rs1449445; rs1449446; rs1449447; rs1512898; rs16857879; rs16857889; rs16857967; rs1900927; rs1913185; rs1913186; rs35880277; rs3749282; rs4342076; rs6768400; rs6768405; rs6771118; rs6792464; rs7623263; rs7645622; rs7646579; rs7646646; rs7646759; rs9853017

# Metabolic_Enzyme_1_General_References:
9054364; 10372558; 12881513

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5539

# Metabolic_Enzyme_2_Name:
Prolyl 4-hydroxylase subunit alpha-1 precursor

# Metabolic_Enzyme_2_Synonyms:
4-PH alpha-1; Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-1 subunit

# Metabolic_Enzyme_2_Gene_Name:
P4HA1

# Metabolic_Enzyme_2_Protein_Sequence:
>Prolyl 4hydroxylase subunit alpha1 precursor
MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA
EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY
FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY
YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR
ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKM
TPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRL
RRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANY
GVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG
TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE

# Metabolic_Enzyme_2_Number_of_Residues:
534

# Metabolic_Enzyme_2_Molecular_Weight:
61050

# Metabolic_Enzyme_2_Theoretical_pI:
5.84

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the posttranslational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins

# Metabolic_Enzyme_2_Pathway:
map00330  Arginine and proline metabolism

# Metabolic_Enzyme_2_Reaction:
procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF03171:2OG-FeII_Oxy;
PF08336:P4Ha_N;
PF07719:TPR_2

# Metabolic_Enzyme_2_Signals:
1-17

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.14.11.2

# Metabolic_Enzyme_2_GenBank_ID_Protein:
190786

# Metabolic_Enzyme_2_SwissProt_ID:
P4HA1_HUMAN (P13674)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
P4HA1

# Metabolic_Enzyme_2_Geneatlas_id:
P4HA1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:8546

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum lumen

# Metabolic_Enzyme_2_Gene_Sequence:
>1605 bp
ATGATCTGGTATATATTAATTATAGGAATTCTGCTTCCCCAGTCTTTGGCTCATCCAGGC
TTTTTTACTTCAATTGGTCAGATGACTGATTTGATCCATACTGAGAAAGATCTGGTGACT
TCTCTGAAAGATTATATTAAGGCAGAAGAGGACAAGTTAGAACAAATAAAAAAATGGGCA
GAGAAGTTAGATCGGCTAACTAGTACAGCGACAAAAGATCCAGAAGGATTTGTTGGGCAT
CCAGTAAATGCATTCAAATTAATGAAACGTCTGAATACTGAGTGGAGTGAGTTGGAGAAT
CTGGTCCTTAAGGATATGTCAGATGGCTTTATCTCTAACCTAACCATTCAGAGACCAGTA
CTTTCTAATGATGAAGATCAGGTTGGGGCAGCCAAAGCTCTGTTACGTCTCCAGGATACC
TACAATTTGGATACAGATACCATCTCAAAGGGTAATCTTCCAGGAGTGAAACACAAATCT
TTTCTAACGGCTGAGGACTGCTTTGAGTTGGGCAAAGTGGCCTATACAGAAGCAGATTAT
TACCATACGGAACTGTGGATGGAACAAGCCCTAAGGCAACTGGATGAAGGCGAGATTTCT
ACCATAGATAAAGTCTCTGTTCTAGATTATTTGAGCTATGCGGTATATCAGCAGGGAGAC
CTGGATAAGGCACTTTTGCTCACAAAGAAGCTTCTTGAACTAGATCCTGAACATCAGAGA
GCTAATGGTAACTTAAAATATTTTGAGTATATAATGGCTAAAGAAAAAGATGTCAATAAG
TCTGCTTCAGATGACCAATCTGATCAGAAAACTACACCAAAGAAAAAAGGGGTTGCTGTG
GATTACCTGCCAGAGAGACAGAAGTACGAAATGCTGTGCCGTGGGGAGGGTATCAAAATG
ACCCCTCGGAGACAGAAAAAACTCTTTTGCCGCTACCATGATGGAAACCGTAATCCTAAA
TTTATTCTGGCTCCAGCTAAACAGGAGGATGAATGGGACAAGCCTCGTATTATTCGCTTC
CATGATATTATTTCTGATGCAGAAATTGAAATCGTCAAAGACCTAGCAAAACCAAGGCTG
AGCCGAGCTACAGTACATGACCCTGAGACTGGAAAATTGACCACAGCACAGTACAGAGTA
TCTAAGAGTGCCTGGCTCTCTGGCTATGAAAATCCTGTGGTGTCTCGAATTAATATGAGA
ATACAAGATCTAACAGGACTAGATGTTTCCACAGCAGAGGAATTACAGGTAGCAAATTAT
GGAGTTGGAGGACAGTATGAACCCCATTTTGACTTTGCACGGAAAGATGAGCCAGATGCT
TTCAAAGAGCTGGGGACAGGAAATAGAATTGCTACATGGCTGTTTTATATGAGTGATGTG
TCTGCAGGAGGAGCCACTGTTTTTCCTGAAGTTGGAGCTAGTGTTTGGCCCAAAAAAGGA
ACTGCTGTTTTCTGGTATAATCTGTTTGCCAGTGGAGAAGGAGATTATAGTACACGGCAT
GCAGCCTGTCCAGTGCTAGTTGGCAACAAATGGGTATCCAATAAATGGCTCCATGAACGT
GGACAAGAATTTCGAAGACCTTGTACGTTGTCAGAATTGGAATGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M24486

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_2_Locus:
10q21.3-q23.1

# Metabolic_Enzyme_2_SNPs:
rs7920974; rs7078127; rs6480667; rs12570974; rs6480668; rs10823977; rs7905836; rs11000516; rs12242222; rs12260669; rs11000517; rs12242214; rs12571459; rs12573499; rs7095810; rs4405231; rs6480666; rs7095904; rs7088078; rs2394928; rs7072019; rs11000515; rs7915269; rs12217855; rs9787672; rs28384495; rs12261293; rs2394919; rs11597837; rs7077346; rs7077281; rs12766755; rs12573512; rs6480653; rs3736278; rs7094342; rs7072071; rs7904719; rs7076642; rs6480655; rs7085141; rs10823975; rs6480654; rs12253630; rs6480661; rs12244027; rs7908682; rs10762535; rs6480660; rs4572061; rs11000491; rs6480659; rs4387274; rs6480663; rs7078818; rs6480662; rs12253317; rs12261668; rs4366408; rs12255146; rs12249050; rs11000506; rs12248308; rs12262696; rs9663510; rs2394920; rs12260461; rs12253518; rs4469800; rs11000510; rs12244049; rs7095061; rs6480664; rs6480658; rs7911861; rs12247364; rs10458655; rs12249126; rs7912848; rs11000499; rs10823976; rs12241143; rs7903684; rs11000511; rs9787516; rs6480665; rs12258500; rs12243988; rs7898822; rs16930271; rs12769591; rs12249431; rs12243451; rs12571941; rs7918396; rs7901481; rs1140462; rs1130885; rs1130886; rs34567673; rs34312165; rs1130890; rs1130887; rs34845894; rs1130884; rs11000512; rs11559264; rs1130889; rs35382319; rs2894191; rs28679854; rs34584160; rs34990120; rs11334323; rs12764491; rs12264323; rs28548263; rs34903468; rs7913148; rs34088796; rs12259071; rs35281975; rs12778451; rs11000520; rs34996723; rs34701143; rs35214128; rs12253350; rs12777708; rs11000514; rs10823980; rs34645636; rs10691278; rs10674198; rs11000513; rs11340358; rs3065972; rs35159575; rs7072016; rs7076700; rs10700344; rs2894192; rs11336622; rs11000519; rs12764311; rs5786098; rs36056230; rs1804257; rs12764504; rs12780338; rs35811135; rs10561551; rs36105566; rs35838791; rs12572256; rs35462247; rs10674781; rs11400869; rs11000497; rs28692884; rs11599563; rs10649250; rs4745712; rs12416008; rs35466966; rs12164712; rs17658374; rs12769358; rs11000505; rs11393613; rs34854861; rs12262881; rs34399366; rs11000508; rs34610783; rs11389497; rs3830350; rs12771344; rs35884198; rs35112393; rs11275675; rs11814343; rs3998391; rs7896744; rs12248714; rs7913609; rs34379137; rs12255388; rs11000500; rs12262986; rs11000504; rs12246277; rs34457485; rs11527421; rs35176849; rs3065978; rs12416021; rs35875050; rs10603432; rs12258140; rs2894193; rs11498022; rs11000503; rs12258753; rs35527169; rs12240932; rs41307520; rs34420722; rs9663290; rs35435004; rs36107511; rs12570010; rs11000493; rs12411647; rs28853423; rs2394929; rs35190522; rs12246228; rs5786097; rs10539580; rs35067388; rs7921747; rs7902639; rs10584360; rs11000502; rs34461487; rs35914404; rs36080367; rs12251674; rs12253449; rs11498023; rs11398474; rs2394921; rs7908892; rs41315002; rs9732032; rs12262714; rs35537940; rs11000494; rs41307512; rs12248134; rs35484631; rs9787606; rs4745711; rs35199506; rs12243819; rs34565865; rs7095773; rs10634037; rs10661785; rs11497795; rs7912619; rs34677025; rs12263220; rs10698728; rs11000486; rs11000487; rs11000488; rs11000489; rs11000490; rs11813121; rs12573768; rs16930262; rs2394924; rs2394925; rs2394926; rs34162681; rs35323750; rs3998396; rs4258298; rs4522088; rs4529828; rs7071334; rs7076718; rs7077056; rs7078081; rs7082363; rs7094115; rs7894359; rs7896197; rs7897191; rs7906123; rs7907485; rs7922533

# Metabolic_Enzyme_2_General_References:
2543975; 7961714

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5484

# Metabolic_Enzyme_3_Name:
Peptidyl-glycine alpha-amidating monooxygenase precursor

# Metabolic_Enzyme_3_Synonyms:
PAM[Includes: Peptidylglycine alpha-hydroxylating monooxygenase; PHM; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase; Peptidylamidoglycolate lyase; PAL]

# Metabolic_Enzyme_3_Gene_Name:
PAM

# Metabolic_Enzyme_3_Protein_Sequence:
>Peptidylglycine alphaamidating monooxygenase precursor
MAGRVPSLLVLLVFPSSCLAFRSPLSVFKRFKETTRPFSNECLGTTRPVVPIDSSDFALD
IRMPGVTPKQSDTYFCMSMRIPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWF
CDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKD
CSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRVHTHH
LGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATH
IGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHE
HHKETEYKDKIPLLQQPKREEEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKAESES
DLVAEIANVVQKKDLGRSDAREGAEHERGNAILVRDRIHKFHRLVSTLRPPESRVFSLQQ
PPPGEGTWEPEHTGDFHMEEALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSF
DSKFVYQQIGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALH
QVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFS
PSGKFITQWGEESSGSSPLPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVR
EIKHSSFGRNVFAISYIPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFD
MPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEIKEAEAVVETKMEN
KPTSSELQKMQEKQKLIKEPGSGVPVVLITTLLVIPVVVLLAIAIFIRWKKSRAFGDSEH
KLETSSGRVLGRFRGKGSGGLNLGNFFASRKGYSRKGFDRLSTEGSDQEKEDDGSESEEE
YSAPLPALAPSSS

# Metabolic_Enzyme_3_Number_of_Residues:
973

# Metabolic_Enzyme_3_Molecular_Weight:
108333

# Metabolic_Enzyme_3_Theoretical_pI:
6.39

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
Function:  peptidylglycine monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  peptide metabolism
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Bifunctional enzyme that catalyzes 2 sequencial steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity

# Metabolic_Enzyme_3_Pathway:
Not Available

# Metabolic_Enzyme_3_Reaction:
peptidylamidoglycolate = peptidyl amide + glyoxylate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF03712:Cu2_monoox_C;
PF01082:Cu2_monooxygen;
PF01436:NHL

# Metabolic_Enzyme_3_Signals:
1-20

# Metabolic_Enzyme_3_Transmembrane_Regions:
864-887

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.14.17.3;EC 4.3.2.5

# Metabolic_Enzyme_3_GenBank_ID_Protein:
189595

# Metabolic_Enzyme_3_SwissProt_ID:
AMD_HUMAN (P19021)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
PAM

# Metabolic_Enzyme_3_Geneatlas_id:
PAM

# Metabolic_Enzyme_3_hgnc_id:
HGNC:8596

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Isoform 1:Membrane; single-pass type I membrane protein. Isoform 2:Membrane; single-pass type I membrane protein. Isoform 3:Secreted protein. Isoform 4:Secreted protein. Note=Secreted from secretory granules

# Metabolic_Enzyme_3_Gene_Sequence:
>2925 bp
ATGGCTGGCCGCGTCCCTAGCCTGCTAGTTCTCCTTGTTTTTCCAAGCAGCTGTTTGGCT
TTCCGAAGCCCACTTTCTGTCTTTAAGAGGTTTAAAGAAACTACCAGACCATTTTCCAAT
GAATGTCTTGGTACCACCAGACCCGTAGTTCCTATTGATTCATCAGATTTTGCATTGGAT
ATTCGCATGCCTGGGGTTACACCTAAACAGTCCGATACATACTTCTGCATGTCTATGCGA
ATACCAGTGGATGAGGAAGCCTTCGTGATTGACTTCAAGCCTCGAGCCAGCATGGATACT
GTCCATCACATGTTACTTTTTGGATGCAATATGCCTTCATCCACTGGAAGTTACTGGTTT
TGTGATGAAGGAACCTGTACAGATAAAGCCAATATTCTGTATGCCTGGGCGAGAAATGCT
CCCCCTACCCGGCTCCCCAAAGGTGTTGGATTCAGAGTTGGAGGAGAGACTGGAAGTAAA
TACTTTGTACTACAGGTACACTATGGGGATATTAGTGCTTTTAGAGATAATAACAAGGAC
TGTTCTGGTGTGTCCTTACACCTCACACGTCTGCCACAGCCTTTAATTGCTGGCATGTAC
CTTATGATGTCTGTTGACACTGTTATCCCAGCAGGAGAAAAAGTGGTGAATTCTGACATT
TCATGCCATTATAAAAATTATCCAATGCATGTCTTTGCCTATAGAGTTCACACTCACCAT
TTAGGTAAGGTAGTAAGTGGATACAGAGTAAGAAATGGACAGTGGACACTGATTGGACGG
CAGAGCCCTCAGCTGCCACAGGCTTTCTACCCTGTGGGGCATCCAGTTGATGTAAGTTTT
GGTGACCTACTGGCTGCAAGATGTGTATTCACTGGTGAAGGAAGGACAGAAGCCACACAC
ATTGGTGGCACGTCTAGTGATGAAATGTGCAACTTATACATTATGTATTACATGGAAGCC
AAGCATGCAGTTTCTTTCATGACCTGTACCCAGAATGTAGCTCCAGATATGTTCAGAACC
ATACCACCAGAGGCCAACATTCCAATTCCCGTGAAGTCTGATATGGTTATGATGCATGAA
CATCATAAAGAAACAGAATATAAAGATAAGATTCCTTTACTACAGCAGCCAAAACGAGAA
GAAGAAGAAGTGTTAGACCAGGGTGATTTCTATTCACTACTTTCCAAGCTGCTAGGAGAA
AGGGAAGATGTTGTTCATGTGCACAAATATAATCCTACAGAAAAGGCAGAATCAGAGTCA
GACCTGGTAGCTGAGATTGCAAATGTAGTCCAAAAAAAGGATCTTGGTCGATCTGATGCC
AGAGAGGGTGCAGAACATGAGAGGGGTAATGCTATTCTTGTCAGAGACAGAATTCACAAA
TTCCACAGACTAGTATCTACCTTGAGGCCACCAGAGAGCAGAGTTTTCTCATTACAGCAG
CCCCCACCTGGTGAAGGCACCTGGGAACCAGAACACACAGGAGATTTCCACATGGAAGAG
GCACTGGATTGGCCTGGAGTATACTTGTTACCAGGCCAGGTTTCTGGGGTGGCTCTAGAC
CCTAAGAATAACCTGGTGATTTTCCACAGAGGTGACCATGTCTGGGATGGAAACTCGTTT
GACAGCAAGTTTGTTTACCAGCAAATAGGACTCGGACCAATTGAAGAAGACACTATTCTT
GTCATAGATCCAAATAATGCTGCAGTACTCCAGTCCAGTGAAAAAAATCTGTTTTACTTG
CCACATGGCTTGAGTATAGATAAAGATGGGAATTATTGGGTCACAGACGTGGCTCTCCAT
CAGGTGTTCAAACTGGATCCAAACAATAAAGAAGGCCCTGTATTAATCCTGGGAAGGAGC
ATGCAACCAGGCAGTGACCAGAATCACTTCTGTCAACCCACTGATGTGGCTGTGGATCCA
GGCACTGGAGCCATTTATGTATCAGATGGTTACTGCAACAGCAGGATTGTGCAGTTTTCA
CCAAGTGGAAAGTTCATCACACAGTGGGGAGAAGAGTCTTCAGGGAGCAGTCCTCTGCCA
GGCCAGTTCACTGTTCCTCACAGCTTGGCTCTTGTGCCTCTTTTGGGCCAATTATGTGTG
GCAGACCGGGAAAATGGTCGGATCCAGTGTTTTAAAACTGACACCAAAGAATTTGTGAGA
GAGATTAAGCATTCATCATTTGGAAGAAATGTATTTGCAATTTCATATATACCAGGCTTG
CTCTTTGCAGTGAATGGGAAGCCTCATTTTGGGGACCAAGAACCTGTACAAGGATTTGTG
ATGAACTTTTCCAATGGGGAAATTATAGACATCTTCAAGCCAGTGCGCAAGCACTTTGAT
ATGCCTCATGATATTGTTGCATCTGAAGATGGGACCGTGTACATTGGAGATGCTCATACC
AACACCGTGTGGAAGTTCACCTTGACTGAGAAATTGGAACATCGATCAGTTAAAAAGGCT
GGCATTGAGGTCCAGGAAATCAAAGAAGCCGAGGCAGTTGTTGAAACCAAAATGGAGAAC
AAACCCACCTCCTCAGAATTGCAGAAGATGCAAGAGAAACAGAAGCTGATCAAAGAGCCA
GGCTCGGGAGTGCCTGTTGTTCTCATTACAACCCTTCTGGTTATTCCGGTGGTTGTCCTG
CTGGCCATTGCCATATTTATTCGGTGGAAAAAATCAAGGGCCTTTGGAGCAGATTCTGAA
CACAAACTCGAGACGAGTTCAGGAAGAGTACTGGGAAGATTTAGAGGAAAGGGAAGTGGA
GGCTTAAACCTTGGTAATTTCTTTGCAAGCCGTAAGGGCTACAGTCGAAAAGGGTTTGAC
CGGCTTAGCACTGAGGGCAGTGACCAAGAGAAAGAGGATGATGGAAGTGAATCAGAAGAG
GAGTATTCAGCACCTCTGCCTGCGCTCGCACCTTCCTCCTCCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M37721

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
2357221; 7999037; 8486658; 8144680

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5485

# Metabolic_Enzyme_4_Name:
Dopamine beta-hydroxylase precursor

# Metabolic_Enzyme_4_Synonyms:
Dopamine beta- monooxygenase

# Metabolic_Enzyme_4_Gene_Name:
DBH

# Metabolic_Enzyme_4_Protein_Sequence:
>Dopamine betahydroxylase precursor
MREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYHIPLDPEGSLELSWNVSYTQEAIHF
QLLVRRLKAG
VLFGMSDRGELENADLVVLWTDGDTAYFADAWSDQKGQIHLDPQQDYQL
LQVQRTPEGLTLLFKRPFGTC
DPKDYLIEDGTVHLVYGILEEPFRSLEAINGSGLQMGL
QRVQLLKPNIPEPELPSDACTMEVQAPNIQIP
SQETTYWCYIKELPKGFSRHHIIKYEP
IVTKGNEALVHHMEVFQCAPEMDSVPHFSGPCDSKMKPDRLNY
CRHVLAAWALGAKAFY
YPEEAGLAFGGPGSSRYLRLEVHYHNPLVIEGRNDSSGIRLYYTAKLRRFNAGI
MELGL
VYTPVMAIPPRETAFILTGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKVVTVLVRDGR
EWEIV
NQDNHYSPHFQEIRMLKKVVSVHPGDVLITSCTYNTEDRELATVGGFGILEEMC
VNYVHYYPQTQLELCK
SAVDAGFLQKYFHLINRFNNEDVCTCPQASVSQQFTSVPWNSF
NRDVLKALYSFAPISMHCNKSSAVRFQ
GEWNLQPLPKVISTLEEPTPQCPTSQGRSPAG
PTVVSIGGGKG

# Metabolic_Enzyme_4_Number_of_Residues:
603

# Metabolic_Enzyme_4_Molecular_Weight:
67614

# Metabolic_Enzyme_4_Theoretical_pI:
6.31

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
Function:  dopamine beta-monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  catecholamine metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  histidine family amino acid metabolism
Process:  histidine metabolism
Process:  histidine catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Conversion of dopamine to noradrenaline

# Metabolic_Enzyme_4_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_4_Reaction:
3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF03712:Cu2_monoox_C;
PF01082:Cu2_monooxygen;
PF03351:DOMON

# Metabolic_Enzyme_4_Signals:
1-25

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.14.17.1

# Metabolic_Enzyme_4_GenBank_ID_Protein:
30474

# Metabolic_Enzyme_4_SwissProt_ID:
DOPO_HUMAN (P09172)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
DBH

# Metabolic_Enzyme_4_Geneatlas_id:
DBH

# Metabolic_Enzyme_4_hgnc_id:
HGNC:2689

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasmic vesicle; secretory vesicle; chromaffin granule. Cytoplasmic vesicle; secretory vesicle; chromaffin granule; chromaffin granule membrane. Note=Exists both in a soluble form (in chromaffin granules) and as membrane bound (the membrane bound form is anchored by an uncleaved signal peptide)

# Metabolic_Enzyme_4_Gene_Sequence:
>1812 bp

ATGCGGGAGGCAGCCTTCATGTACAGCACAGCAGTGGCCATCTTCCTGGTCATCCTGGT
GGCCGCACTGC
AGGGCTCGGCTCCCCGTGAGAGCCCCCTCCCCTATCACATCCCCCTGG
ACCCGGAGGGGTCCCTGGAGCT
CTCATGGAATGTCAGCTACACCCAGGAGGCCATCCAT
TTCCAGCTCCTGGTGCGGAGGCTCAAGGCTGGC
GTCCTGTTTGGGATGTCCGACCGTGG
CGAGCTTGAGAACGCAGATCTCGTGGTGCTCTGGACCGATGGGG
ACACTGCCTATTTTG
CGGACGCCTGGAGTGACCAGAAGGGGCAGATCCACCTGGATCCCCAGCAGGACTA
CCAG
CTGCTGCAGGTGCAGAGGACCCCAGAAGGCCTGACCCTGCTTTTCAAGAGGCCCTTTGGC
ACCTGC
GACCCCAAGGATTACCTCATTGAAGACGGCACTGTCCACTTGGTCTACGGGAT
CCTGGAGGAGCCGTTCC
GGTCACTGGAGGCCATCAACGGCTCGGGCCTGCAGATGGGGC
TGCAGAGGGTGCAGCTCCTGAAGCCCAA
TATCCCCGAACCGGAGTTGCCCTCAGACGCG
TGCACCATGGAGGTCCAAGCTCCCAATATCCAGATCCCC
AGCCAGGAGACCACGTACTG
GTGCTACATTAAGGAGCTTCCAAAGGGCTTCTCTCGGCACCACATTATCA
AGTACGAGC
CCATCGTCACCAAGGGCAATGAGGCCCTTGTCCACCACATGGAAGTCTTCCAGTGCGCCC
C
CGAGATGGACAGCGTCCCCCACTTCAGCGGGCCCTGCGACTCCAAGATGAAACCCGAC
CGCCTCAACTAC
TGCCGCCACGTGCTGGCCGCCTGGGCCCTGGGTGCCAAGGCATTTTA
CTACCCAGAGGAAGCCGGCCTTG
CCTTCGGGGGTCCAGGGTCCTCCAGATATCTCCGCC
TGGAAGTTCACTACCACAACCCACTGGTGATAGA
AGGACGAAACGACTCCTCAGGCATC
CGCTTGTACTACACAGCCAAGCTGCGGCGCTTCAACGCGGGGATC
ATGGAGCTGGGACT
GGTGTACACGCCAGTGATGGCCATTCCACCACGGGAGACCGCCTTCATCCTCACTG
GCT
ACTGCACGGACAAGTGCACCCAGCTGGCACTGCCTCCCTCCGGGATCCACATCTTCGCCT
CTCAGCT
CCACACACACCTGACTGGGAGAAAGGTGGTCACAGTGCTGGTCCGGGACGGC
CGGGAGTGGGAGATCGTG
AACCAGGACAATCACTACAGCCCTCACTTCCAGGAGATCCG
CATGTTGAAGAAGGTCGTGTCGGTCCATC
CGGGAGATGTGCTCATCACCTCCTGCACGT
ACAACACGGAAGACCGGGAGCTGGCCACAGTGGGGGGCTT
CGGGATCCTGGAGGAGATG
TGTGTCAACTACGTGCACTACTACCCCCAGACGCAGCTGGAGCTCTGCAAG
ACGGCTGT
GGACGCCGGCTTCCTGCAGAAGTACTTCCACCTCATCAACAGGTTCAACAACGAGGATGT
CT
GCACCTGCCCTCAGGCGTCCGTGTCTCAGCAGTTCACCTCTGTTCCCTGGAACTCCT
TCAACCGCGACGT
ACTGAAGGCCCTGTACAGCTTCGCGCCCATCTCCATGCACTGCAAC
AAGTCCTCAGCCGTCCGCTTCCAG
GGTGAATGGAACCTGCAGCCCCTGCCCAAGGTCAT
CTCCACACTGGAAGAGCCCACCCCACAGTGCCCCA
CCAGCCAGGGCCGAAGCCCTGCTG
GCCCCACCGTTGTCAGCATTGGTGGGGGCAAAGGCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
X13255

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_4_Locus:
9q34

# Metabolic_Enzyme_4_SNPs:
rs5324; rs5320; rs4531; rs5325; rs1108580; rs77905; rs5322; rs5318; rs2519154; rs2797849; rs1541333; rs6479643; rs1611126; rs1108581; rs7035577; rs2797853; rs7876027; rs1611122; rs1611130; rs1611124; rs3025399; rs12343735; rs3025405; rs2797852; rs1541332; rs3025383; rs2519143; rs1611120; rs1611128; rs1611123; rs1611119; rs7862391; rs3025411; rs3025395; rs9657707; rs3025391; rs2519151; rs3025382; rs2007153; rs2797855; rs2283123; rs2283124; rs3025388; rs2519155; rs2873804; rs1548364; rs80858; rs1611125; rs2797851; rs739398; rs3025390; rs3025410; rs129911; rs10993947; rs2283122; rs129913; rs3025413; rs1548367; rs10121827; rs3025401; rs12003344; rs3025387; rs3025403; rs2519153; rs2797854; rs7870239; rs3025393; rs129910; rs7864658; rs2005663; rs3025404; rs3025406; rs1611127; rs2797850; rs3025408; rs3739885; rs129908; rs2519157; rs129909; rs1611118; rs2519152; rs13284520; rs3025392; rs2519144; rs1611114; rs1611115; rs129883; rs129915; rs12002610; rs3025379; rs1611116; rs13306301; rs41316996; rs2797848; rs5319; rs5323; rs3025380; rs13306306; rs5321; rs13306303; rs17851478; rs35465867; rs3025400; rs35043556; rs3739886; rs35067824; rs3025381; rs28419319; rs3025415; rs1548365; rs28481752; rs5901024; rs3081166; rs13306307; rs3025385; rs1611129; rs35246072; rs12001868; rs2519156; rs35528158; rs11278217; rs11283016; rs13293282; rs3025428; rs34469151; rs13306302; rs3025430; rs35806215; rs35682711; rs28662126; rs7032535; rs34932746; rs12003763; rs3025416; rs3025427; rs3025384; rs3025426; rs1548366; rs3025389; rs4333676; rs3025398; rs28738882; rs13306308; rs1548368; rs129912; rs3025386; rs7027680; rs28698922; rs1611121; rs35688529; rs12005180; rs3025396; rs5901023; rs3025414; rs28534474; rs3025407; rs13306305; rs3025402; rs3025429; rs3025409; rs35808071; rs3025394; rs3025412; rs34553440; rs34242880; rs13298385; rs34701710; rs34498190; rs3025377; rs1611117; rs12684659; rs3025433; rs10993904; rs3025432; rs13285918; rs3025378; rs2797847; rs1076150; rs1076153; rs10993885; rs10993886; rs10993948; rs10993949; rs10993950; rs12337651; rs129882; rs129884; rs129885; rs129888; rs129914; rs129916; rs129917; rs129918; rs129919; rs129921; rs129922; rs129923; rs129924; rs129925; rs129926; rs129928; rs129929; rs129930; rs129931; rs17150766; rs1989787; rs2073833; rs2073835; rs2073836; rs2073837; rs2097628; rs2519145; rs2519147; rs2519148; rs2519149; rs2519764; rs2519765; rs3025369; rs3025370; rs3025371; rs3025372; rs3025373; rs3025374; rs3025375; rs3025376; rs3025417; rs3025418; rs3025419; rs3025421; rs3025422; rs3025423; rs3025424; rs3025425; rs3025431; rs3025434; rs3025435; rs3025436; rs3025437; rs3025438; rs3025439; rs3025440; rs3025441; rs3025443; rs6271; rs7043939; rs732833; rs7851898; rs7859358; rs9409875

# Metabolic_Enzyme_4_General_References:
2922261; 3443096; 8546710; 10490716; 10391209; 10391210; 11857564

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5699

# Metabolic_Enzyme_5_Name:
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 precursor

# Metabolic_Enzyme_5_Synonyms:
Lysyl hydroxylase 1; LH1

# Metabolic_Enzyme_5_Gene_Name:
PLOD1

# Metabolic_Enzyme_5_Protein_Sequence:
>Procollagenlysine,2oxoglutarate 5dioxygenase 1 precursor
MRPLLLLALLGWLLLAEAKGDAKPEDNLLVLTVATKETEGFRRFKRSAQFFNYKIQALGL
GEDWNVEKGTSAGGGQKVRLLKKALEKHADKEDLVILFADSYDVLFASGPRELLKKFRQA
RSQVVFSAEELIYPDRRLETKYPVVSDGKRFLGSGGFIGYAPNLSKLVAEWEGQDSDSDQ
LFYTKIFLDPEKREQINITLDHRCRIFQNLDGALDEVVLKFEMGHVRARNLAYDTLPVLI
HGNGPTKLQLNYLGNYIPRFWTFETGCTVCDEGLRSLKGIGDEALPTVLVGVFIEQPTPF
VSLFFQRLLRLHYPQKHMRLFIHNHEQHHKAQVEEFLAQHGSEYQSVKLVGPEVRMANAD
ARNMGADLCRQDRSCTYYFSVDADVALTEPNSLRLLIQQNKNVIAPLMTRHGRLWSNFWG
ALSADGYYARSEDYVDIVQGRRVGVWNVPYISNIYLIKGSALRGELQSSDLFHHSKLDPD
MAFCANIRQQDVFMFLTNRHTLGHLLSLDSYRTTHLHNDLWEVFSNPEDWKEKYIHQNYT
KALAGKLVETPCPDVYWFPIFTEVACDELVEEMEHFGQWSLGNNKDNRIQGGYENVPTID
IHMNQIGFEREWHKFLLEYIAPMTEKLYPGYYTRAQFDLAFVVRYKPDEQPSLMPHHDAS
TFTINIALNRVGVDYEGGGCRFLRYNCSIRAPRKGWTLMHPGRLTHYHEGLPTTRGTRYI
AVSFVDP

# Metabolic_Enzyme_5_Number_of_Residues:
727

# Metabolic_Enzyme_5_Molecular_Weight:
83551

# Metabolic_Enzyme_5_Theoretical_pI:
6.94

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  procollagen-lysine 5-dioxygenase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  endoplasmic reticulum

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links

# Metabolic_Enzyme_5_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_5_Reaction:
procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF03171:2OG-FeII_Oxy

# Metabolic_Enzyme_5_Signals:
1-18

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.14.11.4

# Metabolic_Enzyme_5_GenBank_ID_Protein:
190074

# Metabolic_Enzyme_5_SwissProt_ID:
PLOD1_HUMAN (Q02809)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
PLOD1

# Metabolic_Enzyme_5_Geneatlas_id:
PLOD1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:9081

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Endoplasmic reticulum; rough endoplasmic reticulum; rough endoplasmic reticulum membrane; peripheral membrane protein; lumenal side

# Metabolic_Enzyme_5_Gene_Sequence:
>2184 bp
ATGCGGCCCCTGCTGCTACTGGCCCTGCTGGGCTGGCTGCTGCTGGCCGAAGCGAAGGGC
GACGCCAAGCCGGAGGACAACCTTTTAGTCCTCACGGTGGCCACTAAGGAGACCGAGGGA
TTCCGTCGCTTCAAGCGCTCAGCTCAGTTCTTCAACTACAAGATCCAGGCGCTTGGCCTA
GGGGAGGACTGGAATGTGGAGAAGGGGACGTCGGCAGGTGGAGGGCAGAAGGTCCGGCTG
CTGAAGAAAGCTCTGGAGAAGCACGCAGACAAGGAGGATCTGGTCATTCTCTTCACAGAC
AGCTATGACGTGCTGTTTGCATCGGGGCCCCGGGAGCTCCTGAAGAAGTTCCGGCAGGCC
AGGAGCCAGGTGGTCTTCTCTGCTGAGGAGCTCATCTACCCAGACCGCAGGCTGGAGACC
AAGTATCCGGTGGTGTCCGATGGCAAGAGGTTCCTGGGCTCTGGAGGCTTCATCGGTTAT
GCCCCCAACCTCAGCAAACTGGTGGCCGAGTGGGAGGGCCAGGACAGCGACAGCGATCAG
CTGTTTTACACCAAGATCTTCTTGGACCCGGAGAAGAGGGAGCAGATCAATATCACCCTG
GACCACCGCTGCCGTATCTTCCAGAACCTGGATGGAGCCTTGGATGAGGTCGTGCTCAAG
TTTGAAATGGGCCATGTGAGAGCGAGGAACCTGGCCTATGACACCCTCCCGGTCCTGATC
CATGGCAACGGGCCAACCAAGCTGCAGTTGAACTACCTGGGCAACTACATCCCGCGCTTC
TGGACCTTCGAAACAGGCTGCACCGTGTGTGACGAAGGCTTGCGCAGCCTCAAGGGCATT
GGGGATGAAGCTCTGCCCACGGTCCTGGTCGGCGTGTTCATCGAACAGCCCACGCCGTTT
GTGTCCCTGTTCTTCCAGCGGCTCCTGCGGCTCCACTACCCCCAGAAACACATGCGACTT
TTCATCCACAACCACGAGCAGCACCACAAGGCTCAGGTGGAAGAGTTCCTGGCACAGCAT
GGCAGCGAGTACCAGTCTGTGAAGCTGGTGGGCCCTGAGGTGCGGATGGCGAATGCAGAT
GCCAGGAACATGGGCGCAGACCTGTGCCGGCAGGACCGCAGCTGCACCTACTACTTCAGC
GTGGATGCTGACGTGGCCCTGACCGAGCCCAACAGCCTGCGGCTGCTGATCCAACAGAAC
AAGAATGTCATTGCCCCGCTGATGACCCGGCATGGGAGGCTGTGGTCGAACTTCTGGGGG
GCTCTCAGTGCAGATGGCTACTATGCCCGTTCCGAGGACTACGTGGACATTGTGCAGGGG
CGGCGTGTTGGTGTCTGGAATGTGCCCTATATTTCAAACATCTACTTGATCAAGGGCAGT
GCCCTGCGGGGTGAGCTGCAGTCCTCAGATCTCTTCCACCACAGCAAGCTGGACCCCGAC
ATGGCCTTCTGTGCCAACATCCGGCAGCAGGATGTGTTCATGTTCCTGACCAACCGGCAC
ACCCTTGGCCATCTGCTCTCCCTAGACAGCTACCGCACCACCCACCTGCACAACGACCTC
TGGGAGGTGTTCAGCAACCCCGAGGACTGGAAGGAGAAGTACATCCACCAGAACTACACC
AAAGCCCTGGCAGGGAAGCTGGTGGAGACGCCCTGCCCGGATGTCTATTGGTTCCCCATC
TTCACGGAGGTGGCCTGTGATGAGCTGGTGGAGGAGATGGAGCACTTTGGCCAGTGGTCT
CTGGGCAACAACAAGGACAACCGCATCCAGGGTGGCTACGAGAACGTGCCGACTATTGAC
ATCCACATGAACCAGATCGGCTTTGAGCGGGAGTGGCACAAATTCCTGCTGGAGTACATT
GCGCCCATGACGGAGAAGCTCTACCCCGGCTACTACACCAGGGCCCAGTTTGACCTGGCC
TTTGTCGTCCGCTACAAGCCTGATGAGCAGCCCTCACTGATGCCACACCATGATGCCTCC
ACCTTCACCATCAACATCGCCCTGAACCGAGTCGGGGTGGATTACGAGGGCGGGGGCTGT
CGGTTCCTGCGCTACAACTGTTCCATCCGAGCCCCAAGGAAGGGCTGGACCCTCATGCAC
CCTGGACGACTCACGCATTACCATGAGGGGCTCCCCACCACCAGGGGCACCCGCTACATC
GCAGTCTCCTTCGTCGATCCCTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
L06419

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_5_Locus:
1p36.3-p36.2

# Metabolic_Enzyme_5_SNPs:
rs7551175; rs34878020; rs7551068; rs2273285; rs879690; rs7514577; rs7529452; rs34032489; rs7541079; rs879691; rs35460537; rs2230898; rs2230899; rs2273289; rs1208984; rs3818157; rs2273286; rs6674558; rs1540923; rs7529028; rs2273293; rs6697996; rs2207751; rs4846080; rs3737961; rs2273291; rs3766746; rs6674770; rs7554458; rs760188; rs6665648; rs11585018; rs744754; rs11121846; rs11121845; rs1040669; rs2336381; rs6541011; rs11581068; rs2273290; rs11121844; rs2092857; rs6703931; rs6678553; rs2273288; rs1964839; rs12567779; rs736302; rs11802668; rs3820190; rs11121843; rs6690517; rs7513651; rs6658386; rs7538358; rs11799416; rs7521172; rs7543487; rs760189; rs2180180; rs6682230; rs2273287; rs1811858; rs2336379; rs7543471; rs7529312; rs11810010; rs1208985; rs11584187; rs1075579; rs7543484; rs7418108; rs12564031; rs1966174; rs11587948; rs12061195; rs11553672; rs3177759; rs11553674; rs11553676; rs36005914; rs35958757; rs11553679; rs11553677; rs35656581; rs1804187; rs15431; rs1049519; rs11553681; rs11553673; rs1063393; rs6685691; rs34974878; rs7514470; rs12737433; rs11809981; rs12130493; rs35648170; rs12404000; rs12037764; rs12752010; rs34390330; rs12079940; rs34115393; rs12753494; rs1806948; rs34499671; rs11585264; rs12037576; rs5772480; rs2336380; rs5772479; rs35059519; rs12743705; rs7414602; rs12094848; rs12749807; rs34636670; rs41278622; rs34707621; rs760190; rs35329388; rs6693015; rs35661025; rs33981344; rs2878680; rs12093915; rs4044690; rs2224103; rs35357427; rs1964840; rs35378361; rs3047221; rs34228351; rs35857830; rs35486766; rs6143123; rs4044691; rs35153449; rs35104601; rs12736906; rs34918895; rs34167429; rs6665708; rs35350400; rs35807940; rs11809682; rs41307745; rs4044692; rs12737438; rs35226154; rs12736958; rs6670260; rs12037575; rs3047155; rs12130497; rs35125262; rs34216020; rs12088157; rs34657615; rs1208983; rs12024161; rs35625768; rs12403086; rs1474868; rs2180181; rs2180182; rs2180183; rs2236053; rs2236054; rs2236055; rs34758260; rs3753579; rs3766744; rs4240897; rs4845891; rs4846082; rs6682554; rs7551289

# Metabolic_Enzyme_5_General_References:
1577494; 7713497; 8621606; 8163671; 9617436; 10686424

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5619

# Metabolic_Enzyme_6_Name:
Gamma-butyrobetaine dioxygenase

# Metabolic_Enzyme_6_Synonyms:
Gamma-butyrobetaine,2- oxoglutarate dioxygenase; Gamma-butyrobetaine hydroxylase; Gamma- BBH

# Metabolic_Enzyme_6_Gene_Name:
BBOX1

# Metabolic_Enzyme_6_Protein_Sequence:
>Gammabutyrobetaine dioxygenase
MACTIQKAEALDGAHLMQILWYDEEESLYPAVWLRDNCPCSDCYLDSAKARKLLVEALDV
NIGIKGLIFDRKKVYITWPDEHYSEFQADWLKKRCFSKQARAKLQRELFFPECQYWGSEL
QLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHT
WQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQK
LKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSKHKIIELDDKGQVVRINFNNATRDTIF
DVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISR
HLEGAYADWDVVMSRLRILRQRVENGN

# Metabolic_Enzyme_6_Number_of_Residues:
387

# Metabolic_Enzyme_6_Molecular_Weight:
44715

# Metabolic_Enzyme_6_Theoretical_pI:
6.73

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Catalyzes the formation of L-carnitine from gamma- butyrobetaine

# Metabolic_Enzyme_6_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_6_Reaction:
4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF02668:TauD

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.14.11.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
3746805

# Metabolic_Enzyme_6_SwissProt_ID:
BODG_HUMAN (O75936)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
BBOX1

# Metabolic_Enzyme_6_Geneatlas_id:
BBOX1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:964

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_6_Gene_Sequence:
>1164 bp
ATGGCTTGTACCATCCAAAAGGCAGAAGCACTTGACGGGGCTCATTTGATGCAGATCCTC
TGGTATGATGAGGAAGAGTCTCTCTACCCAGCTGTATGGTTGAGAGACAACTGTCCGTGC
TCTGATTGCTACCTGGATTCTGCAAAAGCACGGAAACTTCTAGTGGAAGCTCTTGATGTG
AACATTGGAATTAAAGGCTTGATATTTGACAGAAAAAAGGTGTACATCACATGGCCCGAT
GAGCATTACAGTGAATTCCAGGCTGATTGGCTGAAGAAAAGATGCTTTTCCAAGCAGGCC
AGAGCAAAGCTCCAAAGAGAATTGTTTTTTCCAGAATGCCAATACTGGGGCTCAGAGCTC
CAGCTACCCACTTTGGATTTTGAAGATGTTTTAAGATATGATGAACATGCATACAAGTGG
CTCTCCACCCTCAAGAAAGTAGGCATAGTAAGACTCACCGGAGCATCTGACAAACCAGGA
GAAGTTTCAAAACTTGGGAAAAGGATGGGTTTCCTCTATCTCACATTTTATGGACATACT
TGGCAAGTGCAAGACAAAATCGATGCAAACAATGTGGCTTACACAACTGGGAAGCTAAGC
TTTCACACTGATTATCCAGCCCTCCATCATCCACCTGGGGTTCAGCTTCTTCACTGCATA
AAGCAAACAGTCACAGGGGGTGATTCAGAAATTGTAGATGGGTTTAATGTGTGCCAAAAA
CTAAAGAAAAATAATCCTCAGGCATTCCAGATTTTGTCCTCTACCTTTGTGGACTTTACA
GACATTGGAGTGGATTACTGTGATTTTTCTGTACAATCAAAACATAAAATTATAGAGTTA
GATGATAAAGGCCAAGTGGTTCGCATCAACTTCAATAACGCAACTAGGGACACAATATTT
GATGTACCTGTTGAAAGAGTTCAGCCTTTTTATGCTGCTCTGAAGGAGTTTGTTGACCTC
ATGAACAGCAAAGAATCCAAGTTTACCTTCAAGATGAATCCAGGTGATGTGATTACTTTT
GATAACTGGCGCTTACTTCATGGCCGACGTAGCTATGAAGCAGGAACTGAGATATCCCGC
CATCTAGAAGGAGCTTATGCTGACTGGGATGTGGTCATGTCAAGGCTTCGTATCTTAAGG
CAGAGGGTGGAGAATGGAAACTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AF082868

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_6_Locus:
11p14.2

# Metabolic_Enzyme_6_SNPs:
rs3183973; rs1044273; rs12385796; rs11029801; rs10835105; rs10767595; rs10835108; rs4923415; rs7107938; rs1031176; rs1445329; rs7108209; rs1348655; rs9667425; rs10767594; rs1596713; rs11029799; rs1445317; rs2305095; rs7113488; rs7124309; rs11029803; rs7479320; rs11029798; rs1445316; rs11029797; rs11029802; rs4922782; rs10767596; rs1596711; rs4923413; rs1044281; rs11029810; rs1445318; rs1445328; rs7124431; rs10835106; rs10767593; rs11029805; rs987687; rs1317726; rs1442936; rs1550617; rs2015372; rs1470272; rs972904; rs12275053; rs7119888; rs7926773; rs4532991; rs4923423; rs1372902; rs7937175; rs10835118; rs7124821; rs7945305; rs1596252; rs7949619; rs7926376; rs4923424; rs11029818; rs1470270; rs1470271; rs1442924; rs7931643; rs11821389; rs1899506; rs7926257; rs1442934; rs16916562; rs2304912; rs7932626; rs11819947; rs7925797; rs1372903; rs2218317; rs1020269; rs7121579; rs4328173; rs3781677; rs11605939; rs10835109; rs10767609; rs11029819; rs996081; rs7930844; rs4923419; rs7926675; rs11029812; rs10835114; rs1442939; rs1445315; rs1126029; rs11029816; rs11824620; rs17309677; rs4278476; rs17243943; rs1584011; rs1372910; rs2099887; rs1442940; rs6484265; rs10767604; rs1442935; rs10501075; rs1900062; rs2165771; rs2165772; rs1899505; rs7942200; rs7129825; rs7124528; rs2165769; rs16916527; rs17309656; rs16925449; rs7111206; rs1117933; rs12292769; rs10835111; rs2016186; rs1442918; rs10767611; rs12294451; rs7934926; rs12271270; rs7925996; rs10835115; rs12270852; rs7105366; rs1596253; rs11029835; rs11029822; rs1442942; rs7949163; rs7124982; rs2083746; rs2351072; rs1596256; rs10835110; rs10767601; rs12269821; rs11029817; rs17309642; rs11029840; rs7927654; rs16916550; rs10501076; rs11511900; rs12282206; rs2083745; rs9666732; rs11828630; rs7951152; rs1838016; rs10767608; rs2351071; rs7103662; rs11029821; rs17243908; rs10767599; rs16916541; rs11029811; rs11029827; rs7936060; rs7101475; rs12786889; rs7113071; rs10835116; rs12288789; rs7926243; rs1550618; rs12277039; rs11029837; rs11602261; rs16916491; rs10767607; rs10742167; rs1348333; rs2351069; rs12285287; rs4539271; rs17243895; rs16916545; rs1442938; rs10767603; rs1813232; rs7939588; rs985597; rs11029833; rs1372904; rs11029795; rs11029796; rs10767592; rs979894; rs16916476; rs10767598; rs11029804; rs11029809; rs10719276; rs7117298; rs35636374; rs4923417; rs7105192; rs11029806; rs7128441; rs12576172; rs34097371; rs34660864; rs11029808; rs34766807; rs35376713; rs11029800; rs35917669; rs12283507; rs34065143; rs7126240; rs35189764; rs11029807; rs4345921; rs12276511; rs5790623; rs34538592; rs4923416; rs12223912; rs28541300; rs10835107; rs4145909; rs34110652; rs1596712; rs2351065; rs34027150; rs12806691; rs5790624; rs5790626; rs7948922; rs12270866; rs35004823; rs12795106; rs34667672; rs11029814; rs1155086; rs7939156; rs33920700; rs11029823; rs12281762; rs1900061; rs969853; rs7118962; rs2165770; rs1596257; rs1442941; rs34033631; rs7121302; rs2099886; rs4456220; rs34651018; rs34566186; rs35133358; rs7106871; rs12796032; rs1900064; rs12283762; rs10767602; rs996080; rs35379904; rs11029829; rs2351068; rs3858352; rs12798621; rs12285873; rs1442937; rs35762464; rs7124832; rs12290117; rs35689575; rs12280183; rs12795275; rs34531204; rs35556063; rs11029813; rs34883956; rs12417452; rs12797016; rs34406124; rs5790625; rs2218316; rs34886674; rs7933763; rs1899507; rs1596255; rs35869743; rs34503251; rs35209473; rs34621792; rs11336654; rs6484262; rs34420345; rs11354714; rs35233420; rs2351073; rs2120970; rs11396790; rs36115556; rs34989862; rs34990215; rs34914489; rs7930368; rs7128424; rs34552334; rs2351067; rs12281711; rs3077755; rs2197193; rs4923422; rs1900063; rs34309577; rs7126076; rs33933274; rs34717773; rs35737389; rs35645117; rs12291195; rs34595485; rs10597096; rs6484263; rs12419903; rs11029825; rs35248831; rs1822333; rs35620055; rs1156471; rs1126030; rs11820992; rs35105576; rs2351066; rs3077754; rs2304913; rs34317776; rs12795462; rs35203991; rs12803967; rs2351070; rs11373738; rs28635996; rs11029820; rs10589070; rs2197189; rs1126028; rs34754536; rs11371497; rs2197192; rs11029815; rs1596254; rs34399289; rs35655267; rs35671221; rs12282200; rs12049843; rs7478929; rs35821992; rs1900065; rs34920955; rs35825160; rs11029826; rs35329237; rs6484266; rs3214719; rs6484264; rs11442866; rs34255947; rs12796839; rs13377286; rs12796835; rs12277417; rs12291206; rs34851998; rs7358459; rs963185; rs34250561; rs12289983; rs5790630; rs7358458; rs35814179; rs2012032; rs5790629; rs4279971; rs12417081; rs5790628; rs5790627; rs11300902; rs35939379; rs1025879; rs10501077; rs10501078; rs10501079; rs10742166; rs11029792; rs11825838; rs11828263; rs12577769; rs1348331; rs1584010; rs16916608; rs1838009; rs2083743; rs3802783; rs4923411; rs4923412; rs4923425; rs7131593; rs7933314; rs7933773; rs7939644

# Metabolic_Enzyme_6_General_References:
9753662

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5701

# Metabolic_Enzyme_7_Name:
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 precursor

# Metabolic_Enzyme_7_Synonyms:
Lysyl hydroxylase 3; LH3

# Metabolic_Enzyme_7_Gene_Name:
PLOD3

# Metabolic_Enzyme_7_Protein_Sequence:
>Procollagenlysine,2oxoglutarate 5dioxygenase 3 precursor
MTSSGPGPRFLLLLPLLLPPAASASDRPRGRDPVNPEKLLVITVATAETEGYLRFLRSAE
FFNYTVRTLGLGEEWRGGDVARTVGGGQKVRWLKKEMEKYADREDMIIMFVDSYDVILAG
SPTELLKKFVQSGSRLLFSAESFCWPEWGLAEQYPEVGTGKRFLNSGGFIGFATTIHQIV
RQWKYKDDDDDQLFYTRLYLDPGLREKLSLNLDHKSRIFQNLNGALDEVVLKFDRNRVRI
RNVAYDTLPIVVHGNGPTKLQLNYLGNYVPNGWTPEGGCGFCNQDRRTLPGGQPPPRVFL
AVFVEQPTPFLPRFLQRLLLLDYPPDRVTLFLHNNEVFHEPHIADSWPQLQDHFSAVKLV
GPEEALSPGEARDMAMDLCRQDPECEFYFSLDADAVLTNLQTLRILIEENRKVIAPMLSR
HGKLWSNFWGALSPDEYYARSEDYVELVQRKRVGVWNVPYISQAYVIRGDTLRMELPQRD
VFSGSDTDPDMAFCKSFRDKGIFLHLSNQHEFGRLLATSRYDTEHLHPDLWQIFDNPVDW
KEQYIHENYSRALEGEGIVEQPCPDVYWFPLLSEQMCDELVAEMEHYGQWSGGRHEDSRL
AGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTESLFPGYHTKARAVMNFVVRYRPDE
QPSLRPHHDSSTFTLNVALNHKGLDYEGGGCRFLRYDCVISSPRKGWALLHPGRLTHYHE
GLPTTWGTRYIMVSFVDP

# Metabolic_Enzyme_7_Number_of_Residues:
738

# Metabolic_Enzyme_7_Molecular_Weight:
84786

# Metabolic_Enzyme_7_Theoretical_pI:
5.95

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  procollagen-lysine 5-dioxygenase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  endoplasmic reticulum

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links

# Metabolic_Enzyme_7_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_7_Reaction:
procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF03171:2OG-FeII_Oxy

# Metabolic_Enzyme_7_Signals:
1-24

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.14.11.4

# Metabolic_Enzyme_7_GenBank_ID_Protein:
3153235

# Metabolic_Enzyme_7_SwissProt_ID:
PLOD3_HUMAN (O60568)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
PLOD3

# Metabolic_Enzyme_7_Geneatlas_id:
PLOD3

# Metabolic_Enzyme_7_hgnc_id:
HGNC:9083

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Endoplasmic reticulum; rough endoplasmic reticulum; rough endoplasmic reticulum membrane; peripheral membrane protein; lumenal side

# Metabolic_Enzyme_7_Gene_Sequence:
>2217 bp
ATGACCTCCTCGGGGCCTGGACCCCGGTTCCTGCTGCTGCTGCCGCTGCTGCTGCCCCCT
GCGGCCTCAGCCTCCGACCGGCCCCGGGGCCGAGACCCGGTCAACCCAGAGAAGCTGCTG
GTGATCACTGTGGCCACAGCTGAAACCGAGGGGTACCTGCGTTTCCTGCGCTCTGCGGAG
TTCTTCAACTACACTGTGCGGACCCTGGGCCTGGGAGAGGAGTGGCGAGGGGGTGATGTG
GCTCGAACAGTTGGTGGAGGACAGAAGGTCCGGTGGTTAAAGAAGGAAATGGAGAAATAC
GCTGACCGGGAGGATATGATCATCATGTTTGTGGATAGCTACGACGTGATTCTGGCCGGC
AGCCCCACAGAGCTGCTGAAGAAGTTCGTCCAGAGTGGCAGCCGCCTGCTCTTCTCTGCA
GAGAGCTTCTGCTGGCCCGAGTGGGGGCTGGCGGAGCAGTACCCTGAGGTGGGCACGGGG
AAGCGCTTCCTCAATTCTGGTGGATTCATCGGTTTTGCCACCACCATCCACCAAATCGTG
CGCCAGTGGAAGTACAAGGATGATGACGACGACCAGCTGTTCTACACACGGCTCTACCTG
GACCCAGGACTGAGGGAGAAACTCAGCCTTAATCTGGATCATAAGTCTCGGATCTTTCAG
AACCTCAACGGGGCTTTAGATGAAGTGGTTTTAAAGTTTGATCGGAACCGTGTGCGTATC
CGGAACGTGGCCTACGACACGCTCCCCATTGTGGTCCATGGAAACGGTCCCACTAAGCTG
CAGCTCAACTACCTGGGAAACTACGTCCCCAATGGCTGGACTCCTGAGGGAGGCTGTGGC
TTCTGCAACCAGGACCGGAGGACACTCCCGGGGGGGCAGCCTCCCCCCCGGGTGTTTCTG
GCCGTGTTTGTGGAACAGCCTACTCCGTTTCTGCCCCGCTTCCTGCAGCGGCTGCTACTC
CTGGACTATCCCCCCGACAGGGTCACCCTTTTCCTGCACAACAACGAGGTCTTCCATGAA
CCCCACATCGCTGACTCCTGGCCGCAGCTCCAGGACCACTTCTCAGCTGTGAAGCTCGTG
GGGCCGGAGGAGGCTCTGAGCCCAGGCGAGGCCAGGGACATGGCCATGGACCTGTGTCGG
CAGGACCCCGAGTGTGAGTTCTACTTCAGCCTGGACGCCGACGCTGTCCTCACCAACCTG
CAGACCCTGCGTATCCTCATTGAGGAGAACAGGAAGGTGATCGCCCCCATGCTGTCCCGC
CACGGCAAGCTGTGGTCCAACTTCTGGGGCGCCCTGAGCCCCGATGAGTACTACGCCCGC
TCCGAGGACTACGTGGAGCTGGTGCAGCGGAAGCGAGTGGGTGTGTGGAATGTACCATAC
ATCTCCCAGGCCTATGTGATCCGGGGTGATACCCTGCGGATGGAGCTGCCCCAGAGGGAT
GTGTTCTCGGGCAGTGACACAGACCCGGACATGGCCTTCTGTAAGAGCTTTCGAGACAAG
GGCATCTTCCTCCATCTGAGCAATCAGCATGAATTTGGCCGGCTCCTGGCCACTTCCAGA
TACGACACGGAGCACCTGCACCCCGACCTCTGGCAGATCTTCGACAACCCCGTCGACTGG
AAGGAGCAGTACATCCACGAGAACTACAGCCGGGCCCTGGAAGGGGAAGGAATCGTGGAG
CAGCCATGCCCGGACGTGTACTGGTTCCCACTGCTGTCAGAACAAATGTGTGATGAGCTG
GTGGCAGAGATGGAGCACTACGGCCAGTGGTCAGGCGGCCGGCATGAGGATTCAAGGCTG
GCTGGAGGCTACGAGAATGTGCCCACCGTGGACATCCACATGAAGCAGGTGGGGTACGAG
GACCAGTGGCTGCAGCTGCTGCGGACGTATGTGGGCCCCATGACCGAGAGCCTGTTTCCC
GGTTACCACACCAAGGCGCGGGCGGTGATGAACTTTGTGGTTCGCTACCGGCCAGACGAG
CAGCCGTCTCTGCGGCCACACCACGACTCATCCACCTTCACCCTCAACGTTGCCCTCAAC
CACAAGGGCCTGGACTATGAGGGAGGTGGCTGCCGCTTCCTGCGCTACGACTGTGTGATC
TCCTCCCCGAGGAAGGGCTGGGCACTCCTGCACCCCGGCCGCCTCACCCACTACCACGAG
GGGCTGCCAACGACCTGGGGCACACGCTACATCATGGTGTCCTTTGTCGACCCCTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AF046889

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_7_Locus:
7q22

# Metabolic_Enzyme_7_SNPs:
rs1546841; rs1546840; rs7777930; rs1468358; rs9656066; rs2214708; rs4729671; rs917112; rs1546842; rs3213663; rs2301903; rs2286120; rs11973058; rs11975752; rs11975104; rs4729670; rs2301904; rs7802724; rs1972170; rs12667795; rs35929039; rs1134907; rs41281013; rs11546151; rs11546152; rs11546150; rs41281010; rs3779113; rs1811203; rs3988238; rs28373136; rs1972169; rs2107803; rs33991024; rs11971003; rs11973909; rs35647633; rs35513430; rs11525849; rs3988239; rs5886172; rs10233414; rs11525848; rs3779114; rs7799197; rs11295764; rs41281007; rs12670371; rs35753125; rs11525850; rs34242341; rs11974067; rs1811204; rs11977763; rs35607207; rs13244924; rs35664086; rs35159319; rs1004242; rs10215517; rs10246301; rs10260707; rs10265206; rs10487887; rs1056678; rs10953329; rs11769624; rs12410; rs12674140; rs13232135; rs17319250; rs2072168; rs2074685; rs34646598; rs35159414; rs35627324; rs3735337; rs3735338; rs4729669; rs6967483

# Metabolic_Enzyme_7_General_References:
9582318; 9724729; 10686427; 12853948

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5537

# Metabolic_Enzyme_8_Name:
Prolyl 4-hydroxylase subunit alpha-2 precursor

# Metabolic_Enzyme_8_Synonyms:
4-PH alpha-2; Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-2 subunit

# Metabolic_Enzyme_8_Gene_Name:
P4HA2

# Metabolic_Enzyme_8_Protein_Sequence:
>Prolyl 4hydroxylase subunit alpha2 precursor
MKLWVSALLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKS
WANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQR
QFFPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEG
DYYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSH
ERAGGNLRYFEQLLEEEREKTLTNQTEAELATPEGIYERPVDYLPERDVYESLCRGEGVK
LTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPK
LARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVAN
YGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKK
GTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGSTEVD

# Metabolic_Enzyme_8_Number_of_Residues:
535

# Metabolic_Enzyme_8_Molecular_Weight:
60903

# Metabolic_Enzyme_8_Theoretical_pI:
5.43

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
Catalyzes the posttranslational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins

# Metabolic_Enzyme_8_Pathway:
map00330  Arginine and proline metabolism

# Metabolic_Enzyme_8_Reaction:
procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF03171:2OG-FeII_Oxy;
PF08336:P4Ha_N;
PF07719:TPR_2

# Metabolic_Enzyme_8_Signals:
1-21

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.14.11.2

# Metabolic_Enzyme_8_GenBank_ID_Protein:
2439985

# Metabolic_Enzyme_8_SwissProt_ID:
P4HA2_HUMAN (O15460)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
P4HA2

# Metabolic_Enzyme_8_Geneatlas_id:
P4HA2

# Metabolic_Enzyme_8_hgnc_id:
HGNC:8547

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum lumen

# Metabolic_Enzyme_8_Gene_Sequence:
>1608 bp
ATGAAACTCTGGGTGTCTGCATTGCTGATGGCCTGGTTTGGTGTCCTGAGCTGTGTGCAG
GCCGAATTCTTCACCTCTATTGGGCACATGACTGACCTGATTTATGCAGAGAAAGAGCTG
GTGCAGTCTCTGAAAGAGTACATCCTTGTGGAGGAAGCCAAGCTTTCCAAGATTAAGAGC
TGGGCCAACAAAATGGAAGCCTTGACTAGCAAGTCAGCTGCTGATGCTGAGGGCTACCTG
GCTCACCCTGTGAATGCCTACAAACTGGTGAAGCGGCTAAACACAGACTGGCCTGCGCTG
GAGGACCTTGTCCTGCAGGACTCAGCTGCAGGTTTTATCGCCAACCTCTCTGTGCAGCGG
CAGTTCTTCCCCACTGATGAGGACGAGATAGGAGCTGCCAAAGCCCTGATGAGACTTCAG
GACACATACAGGCTGGACCCAGGCACAATTTCCAGAGGGGAACTTCCAGGAACCAAGTAC
CAGGCAATGCTGAGTGTGGATGACTGCTTTGGGATGGGCCGCTCGGCCTACAATGAAGGG
GACTATTATCATACGGTGTTGTGGATGGAGCAGGTGCTAAAGCAGCTTGATGCCGGGGAG
GAGGCCACCACAACCAAGTCACAGGTGCTGGACTACCTCAGCTATGCTGTCTTCCAGTTG
GGTGATCTGCACCGTGCCCTGGAGCTCACCCGCCGCCTGCTCTCCCTTGACCCAAGCCAC
GAACGAGCTGGAGGGAATCTGCGGTACTTTGAGCAGTTATTGGAGGAAGAGAGAGAAAAA
ACGTTAACAAATCAGACAGAAGCTGAGCTAGCAACCCCAGAAGGCATCTATGAGAGGCCT
GTGGACTACCTGCCTGAGAGGGATGTTTACGAGAGCCTCTGTCGTGGGGAGGGTGTCAAA
CTGACACCCCGTAGACAGAAGAGGCTTTTCTGTAGGTACCACCATGGCAACAGGGCCCCA
CAGCTGCTCATTGCCCCCTTCAAAGAGGAGGACGAGTGGGACAGCCCGCACATCGTCAGG
TACTACGATGTCATGTCTGATGAGGAAATCGAGAGGATCAAGGAGATCGCAAAACCTAAA
CTTGCACGAGCCACCGTTCGTGATCCCAAGACAGGAGTCCTCACTGTCGCCAGCTACCGG
GTTTCCAAAAGCTCCTGGCTAGAGGAAGATGATGACCCTGTTGTGGCCCGAGTAAATCGT
CGGATGCAGCATATCACAGGGTTAACAGTAAAGACTGCAGAATTGTTACAGGTTGCAAAT
TATGGAGTGGGAGGACAGTATGAACCGCACTTCGACTTCTCTAGGAATGATGAGCGAGAT
ACTTTCAAGCATTTAGGGACGGGGAATCGTGTGGCTACTTTCTTAAACTACATGAGTGAT
GTAGAAGCTGGTGGTGCCACCGTCTTCCCTGATCTGGGGGCTGCAATTTGGCCTAAGAAG
GGTACAGCTGTGTTCTGGTACAACCTCTTGCGGAGCGGGGAAGGTGACTACCGAACAAGA
CATGCTGCCTGCCCTGTGCTTGTGGGCTGCAAGTGGGTCTCCAATAAGTGGTTCCATGAA
CGAGGACAGGAGTTCTTGAGACCTTGTGGATCAACAGAAGTTGACTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
U90441

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_8_Locus:
5q31

# Metabolic_Enzyme_8_SNPs:
rs7733814; rs157578; rs154486; rs6596070; rs4705849; rs4705926; rs154487; rs7733502; rs11952765; rs128738; rs156029; rs283753; rs246107; rs152047; rs152051; rs156025; rs75189; rs3805681; rs3828675; rs154484; rs3749756; rs3805683; rs4361509; rs2278398; rs12653783; rs7703009; rs12657965; rs156023; rs17618350; rs3792894; rs10052046; rs152050; rs7701237; rs154483; rs156030; rs10075459; rs156027; rs283763; rs17165741; rs159903; rs152049; rs2301579; rs154485; rs188199; rs2081274; rs152048; rs17165762; rs17618604; rs10520127; rs3214098; rs152053; rs159899; rs157577; rs3805685; rs156032; rs246108; rs156033; rs156034; rs7702160; rs3805684; rs1126979; rs1126978; rs3211283; rs28752075; rs41298340; rs34435009; rs15826; rs35313991; rs1008564; rs35334449; rs34045212; rs35183308; rs392587; rs182092; rs185857; rs28692687; rs35974099; rs36094565; rs185858; rs3840353; rs10656798; rs176112; rs13186538; rs3991665; rs36046040; rs28542593; rs35791773; rs2048473; rs172231; rs34410092; rs35792165; rs1987404; rs184015; rs415986; rs175091; rs13166357; rs34132804; rs34157941; rs390763; rs5871448; rs182249; rs13166329; rs35884065; rs446415; rs13186642; rs13179264; rs10065782; rs424089; rs205547; rs34601928; rs35102688; rs13166927; rs166902; rs35194004; rs35497617; rs13166479; rs364504; rs34049016; rs13166932; rs156026; rs185616; rs6875603; rs34637952; rs35626181; rs35536064; rs10036208; rs10051679; rs10058655; rs11741341; rs11749843; rs11952065; rs11955347; rs13188221; rs13190293; rs1511675; rs152055; rs156031; rs156036; rs17165720; rs17165721; rs2077380; rs2089855; rs2405271; rs408931; rs6896703; rs743563; rs9791170

# Metabolic_Enzyme_8_General_References:
9211872; 11606192; 12975309

# Metabolic_Enzyme_8_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8548

# Macromolecular_Interacting_Partner_1_Name:
Glutaredoxin-2, mitochondrial precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
GLRX2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Glutaredoxin2, mitochondrial precursor
MIWRRAALAGTRLVWSRSGSAGWLDRAAGAAGAAAAAASGMESNTSSSLENLATAPVNQI
QETISDNCVVIFSKTSCSYCTMAKKLFHDMNVNYKVVELDLLEYGNQFQDALYKMTGERT
VPRIFVNGTFIGGATDTHRLHKEGKLLPLVHQCYLKKSKRKEFQ

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
164

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
18052

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
9.49

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
 Function:  transporter activity
Function:  electron transporter activity
 ||
>>>
 Process:  homeostasis
Process:  cell homeostasis
Process:  cell redox homeostasis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Posttranslational modification, protein turnover, chaperones

# Macromolecular_Interacting_Partner_1_Specific_Function:
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00462:Glutaredoxin

# Macromolecular_Interacting_Partner_1_Signals:
1-21

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
9507250

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
GLRX2_HUMAN (Q9NS18)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
GLRX2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
GLRX2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:16065

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Isoform 1:Mitochondrion. Isoform 2:Nucleus

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>495 bp
ATGATTTGGCGCCGCGCGGCGCTGGCGGGGACGCGGCTGGTTTGGAGCAGGAGCGGCTCG
GCAGGCTGGCTTGACAGGGCGGCGGGAGCTGCGGGAGCTGCGGCAGCTGCGGCCTCTGGG
ATGGAGAGCAATACATCATCATCTTTGGAGAATTTAGCGACGGCGCCTGTGAACCAGATC
CAAGAAACAATTTCTGATAATTGTGTGGTGATTTTCTCAAAAACATCCTGTTCTTACTGT
ACAATGGCAAAAAAGCTTTTCCATGACATGAATGTTAACTATAAAGTGGTGGAACTGGAC
CTGCTTGAATATGGAAACCAGTTCCAAGATGCTCTTTACAAAATGACTGGTGAAAGAACT
GTTCCAAGAATATTTGTCAATGGTACTTTTATTGGAGGTGCAACTGACACTCATAGGCTT
CACAAAGAAGGAAAATTGCTCCCACTAGTTCATCAGTGTTATTTAAAAAAAAGTAAGAGG
AAAGAATTTCAGTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AF132495

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_1_Locus:
1q31.2-q31.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs10921310; rs1075661; rs912071; rs34353394; rs10801174; rs4657845; rs34961778; rs10801175; rs35995477; rs34839556; rs34603073; rs35057393; rs34029525; rs35843003; rs35891969; rs34615282; rs35358794; rs35214819; rs34147192; rs34533242; rs34839876; rs35629623; rs34589675; rs34833502; rs34262844; rs35241972; rs7544830; rs7547615; rs912070; rs36120583; rs35070966; rs35221108; rs35686837; rs36087945; rs34552619; rs34084081; rs34237236; rs1075660; rs35090051; rs34475657; rs10690193; rs3079948; rs12724659; rs34778656; rs35831330; rs12118724; rs35434160; rs34014687; rs34692395; rs34575782; rs35982829; rs34547448; rs34721216; rs1221539; rs35923929; rs34048785; rs35558858; rs35024625; rs12089411; rs10733078; rs10737620; rs12083536; rs12097567; rs12123511; rs4657843; rs4657844; rs6665069; rs6703727; rs7519292; rs956164; rs9783104

# Macromolecular_Interacting_Partner_1_General_References:
11297543; 11397793; 10810093

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8602

# Macromolecular_Interacting_Partner_2_Name:
Hypothetical protein CYBRD1

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
CYBRD1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Hypothetical protein CYBRD1
MAMEGYWRFLALLGSALLVGFLSVIFALVWVLHYREGLGWDGSALEFNWHPVLMVTGFVF
IQGIAIIVYRLPWTWKCSKLLMKSIHAGLNAVAAILAIISVVAVFENHNVNNIANMYSLH
SWVGLIAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGLTE
KLIFSLRDPAYSTFPPEGVFVNTLGLLILVFGALIFWIVTRPQWKRPKEPNSTILHPNGG
TEQGARGSMPAYSGNNMDKSDSELNSEVAARKRNLALDEAGQRSTM

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
286

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
31642

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
9.02

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  Not Available
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF03188:Cytochrom_B561

# Macromolecular_Interacting_Partner_2_Signals:
1-27

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
9-31; 51-73; 85-107; 122-144; 157-179; 199-218

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
62822181

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
Q53TN4_HUMAN (Q53TN4)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
CYBRD1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
CYBRD1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:20797

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>861 bp
ATGGCCATGGAGGGCTACTGGCGCTTCCTGGCGCTGCTGGGGTCGGCACTGCTCGTCGGC
TTCCTGTCGGTGATCTTCGCCCTCGTCTGGGTCCTCCACTACCGAGAGGGGCTTGGCTGG
GATGGGAGCGCACTAGAGTTTAACTGGCACCCAGTGCTCATGGTCACCGGCTTCGTCTTC
ATCCAGGGCATCGCCATCATCGTCTACAGACTGCCGTGGACCTGGAAATGCAGCAAGCTC
CTGATGAAATCCATCCATGCAGGGTTAAATGCAGTTGCTGCCATTCTTGCAATTATCTCT
GTGGTGGCCGTGTTTGAGAACCACAATGTTAACAATATAGCCAATATGTACAGTCTGCAC
AGCTGGGTTGGACTGATAGCTGTCATATGCTATTTGTTACAGCTTCTTTCAGGTTTTTCA
GTCTTTCTGCTTCCATGGGCTCCGCTTTCTCTCCGAGCATTTCTCATGCCCATACATGTT
TATTCTGGAATTGTCATCTTTGGAACAGTGATTGCAACAGCACTTATGGGATTGACAGAG
AAACTGATTTTTTCCCTGAGAGATCCTGCATACAGTACATTCCCGCCAGAAGGTGTTTTC
GTAAATACGCTTGGCCTTCTGATCCTGGTGTTCGGGGCCCTCATTTTTTGGATAGTCACC
AGACCGCAATGGAAACGTCCTAAGGAGCCAAATTCTACCATTCTTCATCCAAATGGAGGC
ACTGAACAGGGAGCAAGAGGTTCCATGCCAGCCTACTCTGGCAACAACATGGACAAATCA
GATTCAGAGTTAAACAGTGAAGTAGCAGCAAGGAAAAGAAACTTAGCTCTGGATGAGGCT
GGGCAGAGATCTACCATGTAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AC007969

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_2_Locus:
2q31.1

# Macromolecular_Interacting_Partner_2_SNPs:
rs10455; rs950163; rs2542938; rs2542940; rs525; rs2542939; rs7585194; rs1047023; rs528; rs1060248; rs1047255; rs6758658; rs12999437; rs3821083; rs12328205; rs16859496; rs1047109; rs2542941; rs11675373; rs7596578; rs11684782; rs968379; rs17554; rs6749185; rs4467241; rs6730441; rs6743679; rs7586144; rs6759240; rs6734372; rs12472239; rs12692966; rs10930479; rs10171386; rs6726306; rs17288042; rs6734880; rs17288294; rs13392902; rs13430202; rs960748; rs16859447; rs10930480; rs16859443; rs960749; rs6751899; rs2356784; rs17288588; rs6731190; rs6710032; rs16859468; rs6741930; rs13024499; rs16859480; rs6730957; rs17222606; rs13009270; rs12475526; rs6704600; rs13418789; rs6706526; rs17288182; rs16859473; rs11687075; rs16823212; rs13428567; rs12999785; rs3049; rs17222641; rs960750; rs3806565; rs12621138; rs1558938; rs11889213; rs884409; rs12692965; rs3806566; rs12692964; rs2674485; rs868106; rs11889130; rs2356782; rs12617802; rs3731976; rs12614717; rs1606927; rs16859487; rs6759970; rs34421610; rs11297167; rs13025082; rs11558131; rs35678610; rs35005621; rs3770417; rs6746474; rs35380972; rs11274272; rs11681001; rs35581304; rs11304118; rs28427085; rs10623587; rs34470927; rs5836342; rs13019199; rs13403066; rs13017139; rs34116694; rs7598064; rs11675978; rs13020413; rs11885559; rs13406134; rs6751911; rs35154976; rs12617339; rs12476341; rs35050777; rs11680991; rs10690489; rs35421358; rs34403080; rs10707105; rs28480510; rs12996339; rs2111719; rs35411294; rs13008611; rs11680989; rs13008482; rs11675982; rs2160850; rs35117681; rs7557499; rs35349251; rs11463294; rs34765726; rs13406106; rs34401954; rs34470385; rs35813699; rs34532626; rs34186168; rs13414895; rs34029335; rs35880894; rs35382628; rs6704910; rs10618404; rs6747652; rs35498424; rs10183083; rs7585974; rs12614720; rs1850033; rs3806568; rs10200648; rs1850032; rs11685419; rs884408; rs10199858; rs7586174; rs10490602; rs10490603; rs11674142; rs11680268; rs11896718; rs12052537; rs12618506; rs13406777; rs13410165; rs1476110; rs16859549; rs17221848; rs17289223; rs2111720; rs2356783; rs2542944; rs2542945; rs2542946; rs2542947; rs2674489; rs2674490; rs2674491; rs2674492; rs2674493; rs2674494; rs2674495; rs2674498; rs2674499; rs2674500; rs3806562; rs3806563; rs3806564; rs4668390; rs6433294; rs6433298; rs6711792; rs6720267; rs6724344; rs6725897; rs6732719; rs7575788; rs7580094; rs918231

# Macromolecular_Interacting_Partner_2_General_References:
Not Available

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8667

# Macromolecular_Interacting_Partner_3_Name:
Solute carrier family 23 member 1

# Macromolecular_Interacting_Partner_3_Synonyms:
Sodium-dependent vitamin C transporter 1; hSVCT1; Na(+/L-ascorbic acid transporter 1; Yolk sac permease-like molecule 3

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC23A1

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Solute carrier family 23 member 1
MRAQEDLEGRTQHETTRDPSTPLPTEPKFDMLYKIEDVPPWYLCILLGFQHYLTCFSGTI
AVPFLLAEALCVGHDQHMVSQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKA
ILALERWKCPPEEEIYGNWSLPLNTSHIWHPRIREVQGAIMVSSVVEVVIGLLGLPGALL
NYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIILFSQYLRNLTFLLPVYRW
GKGLTLLRIQIFKMFPIMLAIMTVWLLCYVLTLTDVLPTDPKAYGFQARTDARGDIMAIA
PWIRIPYPCQWGLPTVTAAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGI
FTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKVGSRRVVQYGAAIMLVLGTIGKFTALF
ASLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLESNPG
AINTGILEVDQILIVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSDMSSS
LKSYDFPIGMGIVKRITFLKYIPICPVFKGFSSSSKDQIAIPEDTPENTETASVCTKV

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
598

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
64816

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.58

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
 Function:  transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Nucleotide transport and metabolism

# Macromolecular_Interacting_Partner_3_Specific_Function:
Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00860:Xan_ur_permease

# Macromolecular_Interacting_Partner_3_Signals:
1-274

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
53-73
82-102
104-124
160-180
208-228
251-271
313-333
359-379
403-423
427-447
458-478
491-511

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
3789785

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
S23A1_HUMAN (Q9UHI7)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC23A1

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC23A1

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:10974

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1797 bp
ATGAGGGCCCAGGAGGACCTCGAGGGCCGGACACAGCATGAAACCACCAGGGACCCCTCG
ACCCCGCTACCCACAGAGCCTAAGTTTGACATGTTGTACAAGATCGAGGACGTGCCACCT
TGGTACCTGTGCATCCTGCTAGGGTTCCAGCACATCCATGACTGCTTACGTGGTACCATC
GCCGTGCCCTTCCTGCTGGCTGAGGCGCTGTGTGTGGGCCACAGCCAGACACTCCATTGT
CAGCTCATCGGCACCATCTTCACGTGCGTGGGCATCACCACTCTCATCCAGACCACCGTG
GGCATCCGGCTGCCGCTGTTCCAGGCCAGTGCCTTTGCATTTCTGGTTCCAGCCAAAGCC
ATACTGGCTCTGGAGAGATGGAAATGCCCCCCGGAAGAGGAGATCTACGGTAACTCCAGT
CTGCCCCTGAACACCTCTCATATTTGGCACCCACGGAATCGGGAGGTCCAGGGTGCAATC
ATGGTGTCCAGCGTGGTGGAGGTGGTGATTGGCCTGCTGGGGCTGCCTGGGGCCCTGCTC
AACTCACTTGGGCCTCTCACAGTCACCCCCACTGTCTCCCTCATTGGCCTTTCTGTCTTC
CAAGCTGCTGGCGACCGACCTGGCTCCCACTGGGGCATCTCAGCTTGCTCCATTCTCCTG
ATCATCCTCTTCTCCCAGTACCTGCGCAACCTCACCTTCCTGCTGCCTGTCTACCGCTGG
GGCAAGGGGCTCACTCTCCTCCGCATCCAGATCTTCAAAATGTTTCCTATCATGCTGGCC
ATCATGACCGTGTGGCTGCTCTGCATTGTCCTGACCTTGACAGACGTGCTGCCCACAGAC
CCAAAAGCCATTGGCTTCCAGGCACGAACCGATGCCCGTGGTGACATCATGGCTATTGCA
CCCTGGATCCGCATCCCCTACCCCTGTCAGTGGGGCCTGCCCACGGTGACTGCGGCTGCT
GTCCTGGGAATGTTCAGCGCCACTCTGGCAGGCATCATTGAGTCCATCGGAGATTACTAC
GCCTGTGCCCGCCTGGCTGGTGCACCACCCCCTCCAGTACATGCTATCAACAGGGGCATC
TTCACCGAAGGCATTTGCTGCATCATCGCGGGGCTATTGGGCACGGGCAACGGGTCCACC
TCGTCCAGTCCCAACATTGGCGTCCTGGGAATTACCAAGGTGGGCAGCCGGCGCGTGGTG
CAGTATGGTGCGGCTATCATGCTGGTCCTGGGCACCATCGGCAAGTTCACGGCCCTCTTC
GCCTCGCTCCCTGACCCCATCCTGGGGGGCATGTTCTGCAGTCTCTTTGGCATGATTACA
GCTGTGGGGCTGTCCAACCTGCAATTTGTGGCACTGAACTCCTCTCGCAACCTCTTCGTG
CTGGGATTTTCCATGTTCTTCGGGCTCACGCTGCCCAATTACCTGGAGTCCAACCCTGGC
GCCATCAATACAGGCATTCTTGAAGTGGATCAGATTCTGATTGTGCTGCTGACCACGGAG
ATGTTTGTGGGCGGGTGCCTTGCTTTCATACTTGACAACACAGTGCCAGGGAGCCCAGAG
GAGCGTGGTCTGATACAGTGGAAAGCTGGGGCTCATGCCAACAGTGACATGTCTTCCAGC
CTGAAGAGCTACGATTTCCCATTTGGGATGGGCATAGTAAAAAGAATTACCTTTCTGAAA
TACATTCCTATCTGCCCAGTCTTCAAAGGATTTTCTTCAAGTTCAAAAGATCAGATTGCA
ATTCCAGAAGACACTCCAGAAAATACAGAAACTGCATCTGTGTGCACCAAGGTCTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF058317

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_3_Locus:
5q31.2-q31.3

# Macromolecular_Interacting_Partner_3_SNPs:
rs33972313; rs35817838; rs34521685; rs6886922; rs6596473; rs6876106; rs4257763; rs11950646; rs34277728; rs34686550; rs34494316; rs11242461; rs34302647; rs34063983; rs35721934; rs10063949; rs10056051; rs6596475; rs11242462; rs6596474; rs6874871; rs36035698; rs4274973; rs34167885; rs35559224; rs35252089; rs7380761; rs10058794; rs12514667; rs10065460; rs34460201; rs34557273; rs35074020; rs11744917; rs12515989; rs6596476; rs5871697; rs34054084; rs10063870; rs1063853; rs1063910; rs11743760; rs11954417; rs3763018; rs3828601; rs3898166; rs3898167; rs4509014; rs6596471; rs7448941; rs9327846; rs9327847

# Macromolecular_Interacting_Partner_3_General_References:
9804989; 10556483; 10556521; 10631088; 11584081; 11396616

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8682

# Macromolecular_Interacting_Partner_4_Name:
Solute carrier family 23 member 2

# Macromolecular_Interacting_Partner_4_Synonyms:
Sodium-dependent vitamin C transporter 2; hSVCT2; Na(+/L-ascorbic acid transporter 2; Yolk sac permease-like molecule 2; Nucleobase transporter-like 1 protein

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC23A2

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Solute carrier family 23 member 2
MMGIGKNTTSKSMEAGSSTEGKYEDEAKHPAFFTLPVVINGGATSSGEQDNEDTELMAIY
TTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAV
PFLLADAMCVGYDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAIL
SLDKWKCNTTDVSVANGTAELLHTEHIWYPRIREIQGAIIMSSLIEVVIGLLGLPGALLK
YIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSK
KGWTAYKLQLFKMFPIILAILVSWLLCFIFTVTDVFPPDSTKYGFYARTDARQGVLLVAP
WFKVPYPFQWGLPTVSAAGVIGMLSAVVASIIESIGDYYACARLSCAPPPPIHAINRGIF
VEGLSCVLDGIFGTGNGSTSSSPNIGVLGITKVGSRRVIQCGAALMLALGMIGKFSALFA
SLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSRNLFVLGFSIFFGLVLPSYLRQNPLV
TGITGIDQVLNVLLTTAMFVGGCVAFILDNTIPGTPEERGIRKWKKGVGKGNKSLDGMES
YNLPFGMNIIKKYRCFSYLPISPTFVGYTWKGLRKSDNSRSSDEDSQATG

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
650

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
70338

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
7.74

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
 Function:  transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Nucleotide transport and metabolism

# Macromolecular_Interacting_Partner_4_Specific_Function:
Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00860:Xan_ur_permease

# Macromolecular_Interacting_Partner_4_Signals:
1-333

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
103-123
140-160
162-182
219-239
242-262
267-287
313-333
372-392
462-482
486-506
514-534
548-568

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
3789789

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
S23A2_HUMAN (Q9UGH3)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC23A2

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC23A2

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:10973

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1953 bp
ATGATGGGTATTGGTAAGAATACCACATCCAAATCAATGGAGGCTGGAAGTTCAACAGAA
GGCAAATACGAAGACGAGGCAAAGCACCCAGCTTTCTTCACTCTTCCGGTGGTGATAAAT
GGAGGCGCCACCTCCAGCGGTGAGCAGGACAATGAGGACACTGAGCTCATGGCGATCTAC
ACTACGGAAAACGGCATTGCAGAAAAGAGCTCTCTCGCTGAGACCCTGGATAGCACTGGC
AGTCTGGACCCCCAGCGATCAGACATGATTTATACCATAGAAGATGTTCCTCCCTGGTAC
CTGTGTATATTTCTGGGGCTACAGCACTACCTGACATGCTTCAGCGGCACGATCGCAGTG
CCCTTCCTGTTGGCCGATGCCATGTGTGTGGGGTACGACCAGTGGGCCACCAGCCAGCTC
ATTGGGACCATTTTCTTCTGTGTGGGAATCACTACTTTGCTACAGACAACGTTTGGATGC
AGGTTACCCCTGTTTCAGACCAGTGCTTTTGCATTTTTGGCCCCTGCTCGAGCCATCCTG
TCTTTAGATAAATGGAAATGTAACACCACAGATGTTTCAGTTGCCAATGGAACAGCAGAG
CTGTTGCACACAGAACACATCTGGTATCCCCGGATCCGAGAGATCCAGGGGGCCATCATC
ATGTCCTCACTGATAGAAGTAGTCATCGGCCTCCTCGGCCTGCCTGGGGCTCTACTGAAG
TACATCGGTCCCTTGACCATTACACCCACGGTGGCCCTAATTGGCCTCTCTGGTTTCCAG
GCAGCGGGGGAGAGAGCCGGGAAGCACTGGGGCATTGCCATGCTGACAATATTCCTAGTA
TTACTGTTTTCTCAATACGCCAGAAATGTTAAATTTCCTCTCCCGATTTATAAATCCAAG
AAAGGATGGACTGCGTACAAGTTACAGCTGTTCAAAATGTTCCCTATCATCCTGGCCATC
CTGGTATCCTGGCTGCTCTGCTTCATCTTCACGGTGACAGATGTCTTCCCTCCCGACAGC
ACAAAGTATGGCTTCTATGCTCGCACAGATGCCAGGCAAGGCGTGCTTCTGGTAGCCCCG
TGGTTTAAGGTTCCATACCCATTTCAGTGGGGACTGCCCACCGTGTCTGCGGCCGGTGTC
ATCGGCATGCTCAGTGCCGTGGTCGCCAGCATCATCGAGTCTATTGGTGACTACTACGCC
TGTGCACGGCTGTCCTGTGCCCCACCCCCCCCCATCCACGCAATAAACAGGGGAATTTTC
GTGGAAGGCCTCTCCTGTGTTCTTGATGGCATATTTGGTACTGGGAATGGCTCTACTTCA
TCCAGTCCCAACATTGGAGTTTTGGGAATTACAAAGGTCGGCAGCCGCCGCGTGATACAG
TGCGGAGCAGCCCTCATGCTCGCTCTGGGCATGATCGGGAAGTTCAGCGCCCTCTTTGCG
TCCCTTCCGGATCCTGTGCTGGGAGCCCTGTTCTGCACGCTCTTTGGAATGATCACAGCT
GTTGGCCTCTCTAACCTGCAGTTCATTGATTTAAATTCTTCCCGGAACCTCTTTGTGCTT
GGATTTTCGATCTTCTTTGGGCTCGTCCTTCCAAGTTACCTCAGACAGAACCCTCTGGTC
ACAGGGATAACAGGAATCGATCAAGTGTTGAACGTCCTTCTCACAACTGCTATGTTTGTA
GGGGGCTGTGTGGCTTTTATCCTGGATAACACCATCCCAGGCACTCCAGAGGAAAGAGGA
ATCCGGAAATGGAAGAAGGGTGTGGGCAAAGGGAACAAATCACTCGACGGCATGGAGTCG
TACAATTTGCCATTTGGCATGAACATTATAAAAAAATACAGATGCTTCAGCTACTTACCC
ATCAGCCCAACCTTTGTGGGCTACACATGGAAAGGCCTCAGGAAGAGCGACAACAGCCGG
AGTTCAGATGAAGACTCCCAGGCCACGGGATAG

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
AF058319

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_4_Locus:
20p13

# Macromolecular_Interacting_Partner_4_SNPs:
rs1776964; rs1110277; rs35550945; rs34460747; rs34073337; rs34568477; rs1776948; rs1519862; rs1715395; rs1131382; rs1776947; rs6053022; rs1279683; rs6053018; rs2681118; rs6139601; rs7267986; rs4815759; rs6139587; rs2681117; rs1879176; rs6139593; rs1554379; rs4813726; rs1628664; rs3914810; rs2748897; rs6053005; rs6053021; rs6052988; rs1543452; rs4813725; rs1519864; rs6053019; rs1879177; rs1776979; rs2064842; rs6052937; rs6038025; rs1776950; rs7263163; rs6116600; rs16990455; rs6053012; rs1519860; rs11904987; rs2423086; rs6037991; rs2681116; rs6052994; rs16990314; rs6053017; rs6053003; rs1776982; rs6052995; rs2748901; rs2748899; rs2423079; rs7260796; rs6038038; rs6053016; rs1519861; rs6052974; rs12479919; rs1519865; rs6052996; rs1969715; rs16990312; rs6052984; rs2423084; rs4076098; rs6037992; rs6107559; rs6053020; rs13037458; rs6139606; rs6052997; rs1715392; rs7273306; rs1715360; rs16990309; rs1401828; rs6052936; rs6139568; rs2681110; rs6038022; rs6116605; rs6053024; rs1519866; rs6139591; rs12625071; rs6052998; rs6053030; rs16990301; rs2423085; rs12626128; rs6052993; rs6052972; rs3761240; rs13042903; rs1776954; rs6052935; rs2326576; rs6084957; rs35618917; rs6038016; rs1715361; rs1299655; rs6038020; rs12625464; rs34495360; rs2681113; rs34153342; rs6052990; rs6052981; rs35326200; rs12626067; rs34950233; rs6052991; rs6052999; rs2423076; rs2203907; rs6116596; rs35904898; rs1519867; rs12480138; rs6084944; rs6139600; rs1776952; rs7269939; rs6053006; rs11697446; rs34508882; rs6053013; rs7267995; rs35524897; rs35560557; rs6133183; rs6052992; rs35731094; rs6116606; rs13042023; rs2423077; rs35653337; rs6084953; rs6053002; rs6076757; rs8120319; rs6052970; rs2203908; rs1343095; rs16990453; rs6038017; rs1715396; rs6076763; rs6139588; rs34295827; rs2423082; rs6053010; rs6038023; rs34408933; rs6133178; rs11908556; rs1923094; rs6053008; rs11907992; rs34747363; rs6139592; rs6133182; rs35916431; rs1776953; rs2748898; rs6038027; rs6053011; rs6053001; rs1971573; rs2946682; rs1715397; rs12481301; rs6038026; rs2423083; rs1279682; rs2681114; rs17340965; rs6038021; rs6133181; rs6053029; rs6139609; rs6116608; rs34348255; rs2254964; rs1715372; rs1776955; rs1776956; rs1715378; rs1715366; rs1776957; rs1715367; rs2681107; rs1715380; rs2298174; rs1715381; rs1715364; rs1715376; rs1891649; rs1776963; rs1715385; rs1629176; rs1776960; rs6037994; rs1715379; rs1715382; rs11699954; rs4987220; rs6084932; rs6052943; rs3848824; rs1715365; rs1715386; rs1776962; rs3787455; rs12329577; rs6052954; rs6116569; rs4815755; rs4987219; rs1776965; rs6107542; rs6133175; rs4813723; rs2275783; rs6107546; rs1715384; rs1614554; rs6038005; rs6052956; rs3787458; rs6116558; rs1715373; rs3787459; rs17339942; rs11905515; rs11696241; rs3787456; rs8122118; rs6038007; rs8115867; rs6037998; rs2748896; rs12481275; rs1715362; rs6107541; rs6116565; rs1776959; rs8125299; rs3787457; rs939258; rs3787470; rs1715375; rs11907533; rs6116571; rs8126036; rs8125804; rs6052961; rs8114176; rs6038003; rs1776977; rs3737321; rs17339921; rs1776970; rs6038010; rs6052946; rs7263731; rs1715374; rs11698817; rs1935972; rs1776968; rs11907979; rs1832978; rs8125856; rs1776958; rs6116566; rs8123436; rs6052942; rs6116556; rs8124137; rs1715368; rs7265456; rs1776972; rs4813724; rs12105993; rs6052962; rs6116562; rs34702220; rs6052958; rs16990338; rs1776966; rs34132722; rs6116557; rs34993852; rs6116568; rs939257; rs35861107; rs6038011; rs1776973; rs6116559; rs11905445; rs13044374; rs1715383; rs6084918; rs17254239; rs1715371; rs11696721; rs1715363; rs1715387; rs4815754; rs6038004; rs6038002; rs13045713; rs4278995; rs35521555; rs6116570; rs8125737; rs34989880; rs6052950; rs11906868; rs16990350; rs16990317; rs1715370; rs6084933; rs1776961; rs8118604; rs33912998; rs35933069; rs6052941; rs17254623; rs6084920; rs11699324; rs2875965; rs1776967; rs17339746; rs6107547; rs3787469; rs6107545; rs36092232; rs1715377; rs6116567; rs8116601; rs7273438; rs6052949; rs6515964; rs12625874; rs12625078; rs6084959; rs7354664; rs2298173; rs41282100; rs34068132; rs34815279; rs35429615; rs11471369; rs12625783; rs36166773; rs6116586; rs6107560; rs6052987; rs2681112; rs6139599; rs11483735; rs6107563; rs35181918; rs11087663; rs11480214; rs6139608; rs12481495; rs6052969; rs36060486; rs34026255; rs35050366; rs1715394; rs6053000; rs6052975; rs6139611; rs35123258; rs6133184; rs6139586; rs34039922; rs6133179; rs7509166; rs33920836; rs6084956; rs6053007; rs34198373; rs11470987; rs6084939; rs3055956; rs6038036; rs7351148; rs34148722; rs11482615; rs34081931; rs6084958; rs6076765; rs10634743; rs6084948; rs36093605; rs7343820; rs6139590; rs6084952; rs34115530; rs2423078; rs6116607; rs6116603; rs6052971; rs35133806; rs13039880; rs7344232; rs7351669; rs34066480; rs6053028; rs2748905; rs2748904; rs11389980; rs11484083; rs35506258; rs35546835; rs6076758; rs11295599; rs6053027; rs6076759; rs34113914; rs1776951; rs35716452; rs6133180; rs6084916; rs36107804; rs4270422; rs35758430; rs34200051; rs35951917; rs2681111; rs34563130; rs2423081; rs6052985; rs6038031; rs35724620; rs1544045; rs11476705; rs35838565; rs7362712; rs6116598; rs6076761; rs34182294; rs35627245; rs13039899; rs6116593; rs6038019; rs11697164; rs34330456; rs13039517; rs6107558; rs11482448; rs36119942; rs13039282; rs6052978; rs6139598; rs1105838; rs7347969; rs11482034; rs13045405; rs2681115; rs6052989; rs34386903; rs7268804; rs6116602; rs6084940; rs35093137; rs41279442; rs6038035; rs6052980; rs6107564; rs11477394; rs35773321; rs13039857; rs6076766; rs6084947; rs35872510; rs7266587; rs11470317; rs6053026; rs35705776; rs11474681; rs11483936; rs6052979; rs6116590; rs6084943; rs11469774; rs34741335; rs6139595; rs11475838; rs10571189; rs35263820; rs11407994; rs4815756; rs2681108; rs2681109; rs13037855; rs6116587; rs35983102; rs10639211; rs34444485; rs34072253; rs7360681; rs33948580; rs6053009; rs6076762; rs10565827; rs6053025; rs33919618; rs11474342; rs11479614; rs11472482; rs33968763; rs3055922; rs34831448; rs12105990; rs8122900; rs11467487; rs6116584; rs6116599; rs34676568; rs34264067; rs11453508; rs13042680; rs6116594; rs6139604; rs6053031; rs11479811; rs35690228; rs6139583; rs36232509; rs10544474; rs35636166; rs6139594; rs2748902; rs34736998; rs2423080; rs1776981; rs11406406; rs11355760; rs11484117; rs6038030; rs11087665; rs6107556; rs35939096; rs6084942; rs12626153; rs6116553; rs2748900; rs35150774; rs3055958; rs6084917; rs6052938; rs6084949; rs34517267; rs35710976; rs2875978; rs8117200; rs6084954; rs13039303; rs6038018; rs7344484; rs11476601; rs11481639; rs6139589; rs34575753; rs7347341; rs11271718; rs11698148; rs6076764; rs4815757; rs6084955; rs6052934; rs6116595; rs11699437; rs34039314; rs34479327; rs34602551; rs6139610; rs35785559; rs6133185; rs6052976; rs6116588; rs6053015; rs13042159; rs11482505; rs35434421; rs6139605; rs6139602; rs35893158; rs35216569; rs13044231; rs1776978; rs6052983; rs4815760; rs3055921; rs6116601; rs8184698; rs11445561; rs34519143; rs6116585; rs34257293; rs35258524; rs6107557; rs10590453; rs6139585; rs35887804; rs6084951; rs6052977; rs6084941; rs1715393; rs2203906; rs6133177; rs11478053; rs6116592; rs35126993; rs12625385; rs6139603; rs6116597; rs10684173; rs11468338; rs36204798; rs11407993; rs6107561; rs11473512; rs35296546; rs6139584; rs6116589; rs6053014; rs35665533; rs35644296; rs34563953; rs13044890; rs4815758; rs35772595; rs6076755; rs35350494; rs35439649; rs6107553; rs6107548; rs6107550; rs6038012; rs11470418; rs11353402; rs6052952; rs34342291; rs11476253; rs11475191; rs6139581; rs6038006; rs11475731; rs5840058; rs35770104; rs6052955; rs2000246; rs6116572; rs6139577; rs6076747; rs33911734; rs11379695; rs6139570; rs6116555; rs6107549; rs11474285; rs6084926; rs2000245; rs6076751; rs11482735; rs34423826; rs6037995; rs6139574; rs7272986; rs9679961; rs6133176; rs4815753; rs35581026; rs35472475; rs6038000; rs6052968; rs11474495; rs1715369; rs35696861; rs6052947; rs34857934; rs6139573; rs3831355; rs6116554; rs6037993; rs1776969; rs6084936; rs7267316; rs6084930; rs6052945; rs34454908; rs34791882; rs6038015; rs6107551; rs11087662; rs6052951; rs9679790; rs35652886; rs6139576; rs35810005; rs6116561; rs6052959; rs6084937; rs6076748; rs11476599; rs11357881; rs6084929; rs6139582; rs16990319; rs11468735; rs6116564; rs6038008; rs7351192; rs1965445; rs7360072; rs3848825; rs6107554; rs35697484; rs35720329; rs36084071; rs35259157; rs6037997; rs6052944; rs35471145; rs6052939; rs11474556; rs6084925; rs6052965; rs6133172; rs34930002; rs35119293; rs6116582; rs6116579; rs35807926; rs12479984; rs6038001; rs35690852; rs11478264; rs2153967; rs41282104; rs6139569; rs35589475; rs34851677; rs1715388; rs35698334; rs11087661; rs7360110; rs11462307; rs6076749; rs12329596; rs6084938; rs2000248; rs6052953; rs34825834; rs6139579; rs6139572; rs7360092; rs35518083; rs6076754; rs35537410; rs35662510; rs11472731; rs6052948; rs6038014; rs34096124; rs6084931; rs6052960; rs6133174; rs35831646; rs6052967; rs6107543; rs6116563; rs6084928; rs6116581; rs35013259; rs11478254; rs35642385; rs11478988; rs6084924; rs35783969; rs3055035; rs11698507; rs35844701; rs35817778; rs3848826; rs11484363; rs6052964; rs13044373; rs11476144; rs3838044; rs7343946; rs939259; rs1113249; rs36004665; rs1776971; rs11467759; rs2000247; rs6084927; rs13037457; rs6133173; rs10537355; rs34483634; rs6139578; rs6139580; rs6139571; rs35229776; rs34817640; rs35881880; rs6076756; rs5840059; rs8123938; rs11474324; rs11479586; rs6052966; rs35101057; rs1539516; rs6037999; rs11431527; rs34853888; rs6052957; rs13043283; rs34292445; rs6116577; rs6038009; rs6116580; rs36040597; rs41282106; rs6139575; rs6037996; rs6107544; rs6076746; rs34104667; rs34651616; rs6052963; rs7360077; rs6107540; rs35519362; rs41282102; rs3848827; rs6076753; rs34779913; rs34953915; rs35749892; rs6084934; rs10536260; rs11482734; rs11478222; rs6116551; rs11087667; rs34618933; rs6133171; rs6139612; rs6037990; rs6084960; rs7352940; rs6037989; rs35031870; rs6076745; rs8115580; rs11467247; rs11290761; rs11469364; rs34330388; rs33990681; rs35688103; rs13037041; rs6116552; rs6133170; rs11469365; rs35708304; rs13042717; rs2423073; rs6037988; rs6053034; rs6084910; rs6116549; rs7262788; rs8119069; rs8126456

# Macromolecular_Interacting_Partner_4_General_References:
9804989; 10471399; 10556521; 10395795; 11396616; 9039502; 12168954; 11780052

# Macromolecular_Interacting_Partner_4_References:
Not Available

# Macromolecular_Interacting_Partner_5_ID:
8799

# Macromolecular_Interacting_Partner_5_Name:
Monooxygenase, DBH-like 1

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
MOXD1

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Monooxygenase, DBHlike 1
MNSFLSVFRYPDFSFPYFPQDYFTNANRELKKDAQQDYHLEYAMENSTHTIIEFTRELHT
CDINDKSITDSTVRVIWAYHHEDAGEAGPKYHDSNRGTKSLRLLNPEKTSVLSTALPYFD
LVNQDVPIPNKDTTYWCQMFKIPVFQEKHHVIKVEPVIQRGHESLVHHILLYQCSNNFND
SVLESGHECYHPNMPDAFLTCETVIFAWAIGGEGFSYPPHVGLSLGTPLDPHYVLLEVHY
DNPTYEEGLIDNSGLRLFYTMDIRKYDAGVIEAGLWVSLFHTIPPGMPEFQSEGHCTLEC
LEEALEAEKPSGIHVFAVLLHAHLAGRGIRLRHFRKGKEMKLLAYDDDFDFNFQEFQYLK
EEQTILPGDNLITECRYNTKDRAEMTWGGLSTRSEMCLSYLLYYPRINLTRCASIPDIME
QLQFIGVKEIYRPVTTWPFIIKSPKQYKNLSFMDAMNKFKWTKKEGLSFNKLVLSLPVNV
RCSKTDNAEWSIQGMTALPPDIERPYKAEPLVCGTSSSSSLHRDFSINLLVCLLLLSCTL
STKSL

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
545

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
62701

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.01

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
 Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
Function:  dopamine beta-monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  catecholamine metabolism
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF03712:Cu2_monoox_C
PF01082:Cu2_monooxygen

# Macromolecular_Interacting_Partner_5_Signals:
Not Available

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
56202500

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
Q5THU6_HUMAN (Q5THU6)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
MOXD1

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
MOXD1

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:21063

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1179 bp
GTTGAGCCAGTGATACAGAGAGGCCATGAGAGTCTGGTGCACCACATCCTGCTCTATCAG
TGCAGCAACAACTTTAACGACAGCGTTCTGGAGTCCGGCCACGAGTGCTATCACCCCAAC
ATGCCCGATGCATTCCTCACCTGTGAAACTGTGATTTTTGCCTGGGCTATTGGTGGAGAG
GGCTTTTCTTATCCACCTCATGTTGGATTATCCCTTGGCACTCCATTAGATCCGCATTAT
GTGCTCCTAGAAGTCCATTATGATAATCCCACTTATGAGGAAGGCTTAATAGATAATTCT
GGACTGAGGTTATTTTACACAATGGATATAAGGAAATATGATGCTGGGGTGATTGAGGCT
GGCCTCTGGGTGAGCCTCTTCCATACCATCCCTCCAGGGATGCCTGAGTTCCAGTCTGAG
GGTCACTGCACTTTGGAGTGCCTGGAAGAGGCTCTGGAAGCCGAAAAGCCAAGTGGAATT
CATGTGTTTGCTGTTCTTCTCCATGCTCACCTGGCTGGCAGAGGCATCAGGCTGCGTCAT
TTTCGAAAAGGGAAGGAAATGAAATTACTTGCCTATGATGATGATTTTGACTTCAATTTC
CAGGAGTTTCAGTATCTAAAGGAAGAACAAACAATCTTACCAGGAGATAACCTAATTACT
GAGTGTCGCTACAACACGAAAGATAGAGCTGAGATGACTTGGGGAGGACTAAGCACCAGG
AGTGAAATGTGTCTCTCATACCTTCTTTATTACCCAAGAATTAATCTTACTCGATGTGCA
AGTATTCCAGACATTATGGAACAACTTCAGTTCATTGGGGTTAAGGAGATCTACAGACCA
GTCACGACCTGGCCTTTCATTATCAAAAGTCCCAAGCAATATAAAAACCTTTCTTTCATG
GATGCTATGAATAAGTTTAAATGGACTAAAAAGGAAGGTCTCTCCTTCAACAAGCTGGTC
CTCAGCCTGCCAGTGAATGTGAGATGTTCCAAGACAGACAATGCTGAGTGGTCGATTCAA
GGAATGACAGCATTACCTCCAGATATAGAAAGACCCTATAAAGCAGAACCTTTGGTGTGT
GGCACGTCTTCTTCCTCTTCCCTGCACAGAGATTTCTCCATCAACTTGCTTGTTTGCCTT
CTGCTACTCAGCTGCACGCTGAGCACCAAGAGCTTGTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AL023578

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_5_Locus:
6q23.1-23.3

# Macromolecular_Interacting_Partner_5_SNPs:
Not Available

# Macromolecular_Interacting_Partner_5_General_References:
Not Available

# Macromolecular_Interacting_Partner_5_References:
Not Available

End of HMDB00044

Beginning of HMDB00045
# Accession_No:
HMDB00045

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-25 13:11:19

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Adenosine monophosphate

# Description:
Adenosine monophosphate, also known as 5'-adenylic acid and abbreviated AMP, is a nucleotide that is found in RNA. It is an ester of phosphoric acid with the nucleoside adenosine. AMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase adenine. AMP can be produced during ATP synthesis by the enzyme adenylate kinase. AMP has recently been approved as a 'Bitter Blocker' additive to foodstuffs. When AMP is added to bitter foods or foods with a bitter aftertaste it makes them seem   'sweeter'.  This potentially makes lower calorie food products more palatable

# Synonyms:
5'-AMP; 5'-adenosine monophosphate; 5'-adenylate; 5'-adenylic acid; AMP; Adenosine 5'-monophosphate; Adenosine 5'-phosphate; Adenosine 5'-phosphorate; Adenosine 5'-phosphoric acid; Adenosine phosphate; Adenosine-5'-monophosphorate; Adenosine-5'-monophosphoric acid; Adenosine-5-monophosphorate; Adenosine-5-monophosphoric acid; Adenovite; Adenylate; Adenylic acid; Cardiomone; Lycedan; Muscle adenylate; Muscle adenylic acid; My-B-Den; Phosaden; Phosphaden; Phosphentaside; adenosine-monophosphate; adenosine-phosphate; My-beta-Den

# Chemical_IUPAC_Name:
[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid

# Chemical_Formula:
C10H14N5O7P

# Chemical_Structure:
tbl_chemical:::HMDB00045_ZOOM.png:::119283153184821191

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00045_THUMB.png:::119283152969282657

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; secondary alcohol; 1,2-diol; primary amine; primary aromatic amine; phosphoric acid ester; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of Alanine and aspartate metabolism; Component of Aminoacyl-tRNA biosynthesis; Component of Arginine and proline metabolism; Component of Biotin metabolism; Component of Fatty acid metabolism; Component of Glutamate metabolism; Component of Glycine, serine and threonine metabolism; Component of Histidine metabolism; Component of Lysine biosynthesis; Component of Methionine metabolism; Component of Nitrogen metabolism; Component of Phenylalanine, tyrosine and tryptophan biosynthesis; Component of Porphyrin and chlorophyll metabolism; Component of Propanoate metabolism; Component of Purine metabolism; Component of Pyrimidine metabolism; Component of Pyruvate metabolism; Component of Selenoamino acid metabolism; Component of Sulfur metabolism; Component of Thiamine metabolism; Component of Tryptophan metabolism; Component of Valine, leucine and isoleucine biosynthesis

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
347.06308

# Molecular_Weight_Avg:
347.22125

# Smiles_String_isomeric:
NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O

# Smiles_String_canonical:
NC1=NC=NC2=C1N=CN2C3OC(COP(O)(O)=O)C(O)C3O

# KEGG_Compound_ID:
C00020

# BioCyc_ID:
AMP

# PubChem_CID:
6083

# PubChem_SID:
11538455; 828450; 836432; 10322529; 831601; 854574; 830458; 836112; 584487; 11486108; 836581; 11109937; 833159; 3131852; 833690; 832885; 10322530; 10322141; 11110215; 7886002; 831649; 11466384; 7885576; 583977; 584452; 838177; 829938; 855346; 832329; 832865; 10584902; 834879; 8025337; 8028526; 836514; 837323; 584776; 585427; 8153801; 855061; 584422; 828448; 830720; 838251; 854578; 834397; 828368; 584440; 585299; 827983; 583923; 838656; 584442; 10317426; 8024258; 583720; 10317432; 841545; 828361; 828458; 838245; 828899; 838945; 7885868; 584455; 11110211; 11109936; 854624; 830875; 831651; 831590; 832127; 7853713; 828366; 11467504; 834616; 828365; 855059; 838654; 584571; 11567806; 829825; 11110505; 174663; 832477; 8028095; 830789; 8145706; 11110499; 8028180; 855182; 854577; 8021128; 837134; 838977; 10322918; 833361; 8026909; 832884; 148970

# OMIM_ID:
102770; 103000

# Metagene_ID:
Not Available

# BiGG_ID:
33534

# Wikipedia_ID:
Adenosine monophosphate

# METLIN_ID:
5111

# Ref_ID:
15882454; 13654353; 6304612; 1781403; 184364; 14965188; 15937757; 4155962; 6656991; 201957

# ChEBI_ID:
16027

# CAS_Registry_Number:
61-19-8

# InChI:
InChI=1/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

# Synthesis_Reference:
Not Available

# Melting_Point:
195 oC

# Melting_Point_predicted:
162.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
10 mg/mL at 20 oC [BEILSTEIN]; 801 mg/mL (sodium salt, HMP expt)

# H2O_Solubility_Predicted:
3.31 mg/mL [Predicted by ALOGPS]

# phys_charge:
-2

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-3.12 [Predicted by ALOGPS]; -3.1 [Predicted by PubChem via XLOGP]; -1.68 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00020.mol:::1132723803281681232

# SDF_File_[Text]:
tbl_chemical:::HMDB00045.sdf:::119283152513315763

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00045.pdb:::119283152796628327

# PDB_ID:
12AS

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::12AS.txt:::1132720900031335382

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::050106_P00_08_IS_1DP_presat.png:::114807184473291564

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::050106_P00_08_IS_1DP_presat.zip:::114807223635179858

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::050106_P00_08_IS_1DP_Assigned.png:::115635152347724532

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050106_P00_08_IS_2DHSQC_1004.png:::114807633954431682

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050106_P00_08_IS_2DHSQC_1004.zip:::114807633955157188

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050106_P00_08_IS_2DHSQC_1004_Assigned.png:::116199095478524546

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Adenosine 5'-monophosphate.gif:::1132732102500775595

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00045_peaks.txt:::115630950906152240

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Adenosine 5'-monophosphate_C.gif:::1132737666951461387

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00045_peaks.txt:::115631070065685825

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000005.png:::116890821710964723

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000005.txt:::116890821710912563

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000005.png:::11689082168759998

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000005.txt:::116890821710961753

# Cellular_Location:
Cytoplasm (Predicted from LogP); Nucleus; endoplasmic reticulum; Extracellular; golgi apparatus; lysosome; mitochondria; peroxisome

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Cellular Cytoplasm

# Concentration_[Normal]:
Blood	51.0 (10.0-92.0)	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	14.0 +/- 3.0	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	6.2	uM	Adult:>18_yrs_old	Male	Normal	13654353
Blood	5.1	uM	Adult:>18_yrs_old	Female	Normal	13654353
Cerebrospinal_Fluid(CSF)	< 0.2	uM	Adult:>18_yrs_old	Both	Normal	6656991
Cellular_Cytoplasm	80.0 (71.0-89.0)	umol/L	Adult:>18_yrs_old	Both	Normal	15882454
Cellular_Cytoplasm	23	uM	Adult:>18_yrs_old	Both	Normal	1781403


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Bronchial Hyperresponsiveness; Coronary Artery Disease

# Pathway_Names:
Purine metabolism;Starch and sucrose metabolism;Nicotinate and nicotinamide metabolism;Pantothenate and CoA biosynthesis;Porphyrin and chlorophyll metabolism;Fatty acid metabolism;Alanine and aspartate metabolism;Valine, leucine and isoleucine biosynthesis;Methionine metabolism;Glycolysis;Pyruvate metabolism;Propanoate metabolism;Reductive carboxylate cycle (CO2 fixation)

# Pathway_Images:
Purine_Synthesis.jpg;;Nicotinamide_synthesis_(NADH).jpg;;;;Aspartate_and_Alanine_metabolism.jpg;Valine,leucine,and_isoleucine_biosynthesis.jpg;Methionine_Metabolism.jpg;Glycolysis.jpg;;;

# KEGG_Images:
map00230;map00500;map00760;map00770;map00860;map00071;map00252;map00290;map00271;map00010;map00620;map00640;map00720

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;;Nicotinamide_synthesis_(NADH)_Graph.jpg;;;;Aspartate_and_Alanine_metabolism_Graph.jpg;Valine,leucine,and_isoleucine_biosynthesis_Graph.jpg;Methionine_Metabolism_Graph.jpg;Glycolysis_Graph.jpg;;;

# Pathway_SBMLs:
Purine_Synthesis.xml;;Nicotinamide_synthesis_(NADH).xml;;;;Aspartate_and_Alanine_metabolism.xml;Valine,leucine,and_isoleucine_biosynthesis.xml;Methionine_Metabolism.xml;Glycolysis.xml;;;

# Metabolic_Enzyme_1_ID:
5832

# Metabolic_Enzyme_1_Name:
Ubiquitin-conjugating enzyme E2 A

# Metabolic_Enzyme_1_Synonyms:
Ubiquitin-protein ligase A; Ubiquitin carrier protein A; HR6A; hHR6A

# Metabolic_Enzyme_1_Gene_Name:
UBE2A

# Metabolic_Enzyme_1_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 
AMSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIMVWNAVIFGPEGTPFEDGTFKLTIEF
TEEYPNKPPTVRFVSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPN
SPANSQAAQLYQENKREYEKRVSAIVEQSWRDC

# Metabolic_Enzyme_1_Number_of_Residues:
152

# Metabolic_Enzyme_1_Molecular_Weight:
17316

# Metabolic_Enzyme_1_Theoretical_pI:
4.79

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA

# Metabolic_Enzyme_1_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_1_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_1_GenBank_ID_Protein:
184044

# Metabolic_Enzyme_1_SwissProt_ID:
UBE2A_HUMAN (P49459)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
UBE2A

# Metabolic_Enzyme_1_Geneatlas_id:
UBE2A

# Metabolic_Enzyme_1_hgnc_id:
HGNC:12472

# Metabolic_Enzyme_1_PDB_ID:
1JAS

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>459 bp
ATGTCCACCCCGGCTCGGCGGCGCCTCATGCGGGACTTCAAGAGGTTGCAGGAGGATCCT
CCAGCCGGAGTCAGCGGGGCTCCGTCCGAGAACAACATAATGGTGTGGAACGCGGTCATT
TTCGGGCCTGAAGGGACCCCGTTTGGGGATGGAACATTTAAACTTACAATAGAATTCACT
GAAGAATATCCAAATAAACCACCTACAGTTAGATTTGTCTCTAAGATGTTCCATCCAAAT
GTCTATGCAGATGGTAGTATATGTCTGGACATACTTCAGAACCGTTGGAGTCCAACCTAT
GATGTGTCTTCCATTCTAACATCCATACAGTCTCTGTTGGATGAACCCAATCCCAATAGT
CCAGCAAACAGCCAGGCTGCTCAGCTGTACCAGGAGAACAAACGGGAATATGAAAAGCGT
GTTTCTGCAATAGTAGAACAAAGCTGGCGTGATTGTTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M74524

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_1_Locus:
Xq24-q25

# Metabolic_Enzyme_1_SNPs:
rs35570533; rs35068848; rs34138874; rs5957190; rs7879933; rs6603535; rs7892285; rs7876612; rs34228798; rs5957188; rs2239005; rs35604136; rs34190757; rs5909640; rs5910619; rs35826268; rs35829336; rs4234; rs35554236; rs14982; rs1803724; rs1803723; rs35317457; rs1803722; rs1803726; rs34146345; rs1803725; rs11373415; rs33999935; rs35923694; rs12835850; rs34720011; rs34118163; rs11380086; rs5957189; rs10633866; rs34149894; rs35955727; rs12833577; rs5909639; rs35701130; rs33997434; rs5910620; rs34712158; rs35506002; rs1057043; rs35217896; rs7058905; rs34326834; rs28614024; rs28716292; rs12863747; rs34782802; rs5903559; rs34147813; rs11423460; rs3031136; rs35707286; rs12850449; rs16995567; rs16995570; rs2018358; rs2233497; rs2233498; rs4825655; rs5910616; rs5956133; rs6645577; rs6645579

# Metabolic_Enzyme_1_General_References:
1717990

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5318

# Metabolic_Enzyme_2_Name:
Ectonucleoside triphosphate diphosphohydrolase 3

# Metabolic_Enzyme_2_Synonyms:
NTPDase 3; Ecto-ATP diphosphohydrolase; ATPDase; Ecto-apyrase; CD39 antigen-like 3; HB6

# Metabolic_Enzyme_2_Gene_Name:
ENTPD3

# Metabolic_Enzyme_2_Protein_Sequence:
>Ectonucleoside triphosphate diphosphohydrolase 3
MFTVLTRQPCEQAGLKALYRTPTIIALVVLLVSIVVLVSITVIQIHKQEVLPPGLKYGIV
LDAGSSRTTVYVYQWPAEKENNTGVVSQTFKCSVKGSGISSYGNNPQDVPRAFEECMQKV
KGQVPSHLHGSTPIHLGATAGMRLLRLQNETAANEVLESIQSYFKSQPFDFRGAQIISGQ
EEGVYGWITANYLMGNFLEKNLWHMWVHPHGVETTGALDLGGASTQISFVAGEKMDLNTS
DIMQVSLYGYVYTLYTHSFQCYGRNEAEKKFLAMLLQNSPTKNHLTNPCYPRDYSISFTM
GHVFDSLCTVDQRPESYNPNDVITFEGTGDPSLCKEKVASIFDFKACHDQETCSFDGVYQ
PKIKGPFVAFAGFYYTASALNLSGSFSLDTFNSSTWNFCSQNWSQLPLLLPKFDEVYARS
YCFSANYIYHLFVNGYKFTEETWPQIHFEKEVGNSSIAWSLGYMLSLTNQIPAESPLIRL
PIEPPVFVGTLAFFTAAALLCLAFLAYLCSATRRKRHSEHAFDHAVDSD

# Metabolic_Enzyme_2_Number_of_Residues:
529

# Metabolic_Enzyme_2_Molecular_Weight:
59106

# Metabolic_Enzyme_2_Theoretical_pI:
6.40

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Has a threefold preference for the hydrolysis of ATP over ADP

# Metabolic_Enzyme_2_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_2_Reaction:
ATP + 2 H2O = AMP + 2 phosphate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01150:GDA1_CD39

# Metabolic_Enzyme_2_Signals:
1-37

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.6.1.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
3335100

# Metabolic_Enzyme_2_SwissProt_ID:
ENTP3_HUMAN (O75355)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ENTPD3

# Metabolic_Enzyme_2_Geneatlas_id:
ENTPD3

# Metabolic_Enzyme_2_hgnc_id:
HGNC:3365

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential)

# Metabolic_Enzyme_2_Gene_Sequence:
>1590 bp
ATGTTCACTGTGCTGACCCGCCAACCATGTGAGCAAGCAGGCCTCAAGGCCCTCTACCGA
ACTCCAACCATCATTGCCTTGGTGGTCTTGCTTGTGAGTATTGTGGTACTTGTGAGTATC
ACTGTCATCCAGATCCACAAGCAAGAGGTCCTCCCTCCAGGACTGAAGTATGGTATTGTG
CTGGATGCCGGGTCTTCAAGAACCACAGTCTACGTGTATCAATGGCCAGCAGAAAAAGAG
AATAATACCGGAGTGGTCAGTCAAACCTTCAAATGTAGTGTGAAAGGCTCTGGAATCTCC
AGCTATGGAAATAACCCCCAAGATGTCCCCAGAGCCTTTGAGGAGTGTATGCAAAAAGTC
AAGGGGCAGGTTCCATCCCACCTCCACGGATCCACCCCCATTCACCTGGGAGCCACGGCT
GGGATGCGCTTGCTGAGGTTGCAAAATGAAACAGCAGCTAATGAAGTCCTTGAAAGCATC
CAAAGCTACTTCAAGTCCCAGCCCTTTGACTTTAGGGGTGCTCAAATCATTTCTGGGCAA
GAAGAAGGGGTATATGGATGGATTACAGCCAACTATTTAATGGGAAATTTCCTGGAGAAG
AACCTGTGGCACATGTGGGTGCACCCGCATGGAGTGGAAACCACGGGTGCCCTGGACTTA
GGTGGTGCCTCCACCCAAATATCCTTCGTGGCAGGAGAGAAGATGGATCTGAACACCAGC
GACATCATGCAGGTGTCCCTGTATGGCTACGTATACACGCTCTACACACACAGCTTCCAG
TGCTATGGCCGGAATGAGGCTGAGAAGAAGTTTCTGGCAATGCTCCTGCAGAATTCTCCT
ACCAAAAACCATCTCACCAATCCCTGTTACCCTCGGGATTATAGCATCAGCTTCACCATG
GGCCATGTATTTGATAGCCTGTGCACTGTGGACCAGAGGCCAGAAAGTTATAACCCCAAT
GATGTCATCACTTTTGAAGGAACTGGGGACCCATCTCTGTGTAAGGAGAAGGTGGCTTCC
ATATTTGACTTCAAAGCTTGCCATGATCAAGAAACCTGTTCTTTTGATGGGGTTTATCAG
CCAAAGATTAAAGGGCCATTTGTGGCTTTTGCAGGATTCTACTACACAGCCAGTGCTTTA
AATCTTTCAGGTAGCTTTTCCCTGGACACCTTCAACTCCAGCACCTGGAATTTCTGCTCA
CAGAATTGGAGTCAGCTCCCACTGCTGCTCCCCAAATTTGATGAGGTATATGCCCGCTCT
TACTGCTTCTCAGCCAACTACATCTACCACTTGTTTGTGAACGGTTACAAATTCACAGAG
GAGACTTGGCCCCAAATACACTTTGAAAAAGAAGTGGGGAATAGCAGCATAGCCTGGTCT
CTTGGCTACATGCTCAGCCTGACCAACCAGATCCCAGCTGAAAGCCCTCTGATCCGTCTG
CCCATAGAACCACCTGTCTTTGTGGGCACCCTCGCTTTCTTCACAGTGGCAGCCTTGCTG
TGTCTGGCATTTCTTGCATACCTGTGTTCAGCAACCAGAAGAAAGAGGCACTCCGAGCAT
GCCTTTGACCATGCAGTGGATTCTGACTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF039917

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_2_Locus:
3p21.3

# Metabolic_Enzyme_2_SNPs:
rs1047855; rs2305521; rs9858868; rs11714871; rs17078798; rs2305522; rs12493020; rs897117; rs1466236; rs6599101; rs6808095; rs9332450; rs6599102; rs954589; rs6783755; rs9848083; rs951560; rs7645864; rs7636719; rs4973999; rs9829800; rs4973997; rs4973898; rs7648952; rs12490249; rs13324109; rs17079011; rs9849348; rs9873394; rs17078941; rs17078813; rs1466237; rs7634375; rs1105745; rs7631893; rs9822909; rs9859026; rs1466238; rs7625736; rs4283549; rs17078812; rs9857824; rs6793596; rs11707673; rs11714032; rs11720360; rs6599100; rs9875245; rs2371185; rs6804157; rs17078914; rs11921197; rs17078916; rs12492035; rs4973994; rs17078921; rs4973989; rs17078959; rs13099333; rs1037516; rs12490275; rs3774805; rs4973998; rs12492777; rs6796122; rs4973993; rs13326389; rs13321169; rs12491944; rs12634013; rs13081891; rs11920596; rs9848049; rs13066971; rs12636697; rs6807397; rs9864380; rs34266806; rs4470483; rs17852714; rs3733167; rs41286046; rs35071108; rs6773917; rs10671439; rs35839072; rs35836679; rs9874499; rs10551054; rs13073943; rs10565031; rs13094752; rs10620040; rs11351492; rs34255517; rs34665572; rs3774806; rs10575365; rs5848563; rs951561; rs13082239; rs3064608; rs11445995; rs9809377; rs35636349; rs35489659; rs4560275; rs6798459; rs10620057; rs13316488; rs13082375; rs6797651; rs6795906; rs13073946; rs3064609; rs41286044; rs35641310; rs35870509; rs13082222; rs13090979; rs9836330; rs34726619; rs28465354; rs10650731; rs9883218; rs9863737; rs9829324; rs1105746; rs5848564; rs9833430; rs9880286; rs9864423; rs3774807; rs28621801; rs34065066; rs6767610; rs11415995; rs3064615; rs35700770; rs5848565; rs9882941; rs34145192; rs34654655; rs10658778; rs11360523; rs9843979; rs36074810; rs9843965; rs13072002; rs35267876; rs41286048; rs9860002; rs9863679; rs13433935; rs35860386; rs9882954; rs11371152; rs9809378; rs28671141; rs28508335; rs34934417; rs6808552; rs10594515; rs9828299; rs1119179; rs12488805; rs12492578; rs12494022; rs2371184; rs6762997; rs6795066; rs7610586; rs7616273; rs7642552; rs9813231; rs9817233; rs9822644; rs9835219; rs9841335; rs9846606; rs9871825; rs9874006; rs9882464

# Metabolic_Enzyme_2_General_References:
9676430; 9675246; 10231536; 11300774

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5833

# Metabolic_Enzyme_3_Name:
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

# Metabolic_Enzyme_3_Synonyms:
GMP-PDE gamma

# Metabolic_Enzyme_3_Gene_Name:
PDE6H

# Metabolic_Enzyme_3_Protein_Sequence:
>Retinal cone rhodopsinsensitive cGMP 3',5'cyclic phosphodiesterase subunit gamma
MSDNTTLPAPASNQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVKGFGDDIPGMEGLGTDI
TVICPWEAFSHLELHELAQFGII

# Metabolic_Enzyme_3_Number_of_Residues:
83

# Metabolic_Enzyme_3_Molecular_Weight:
9074

# Metabolic_Enzyme_3_Theoretical_pI:
9.98

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  cGMP-specific phosphodiesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_3_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF04868:PDE6_gamma

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1311544

# Metabolic_Enzyme_3_SwissProt_ID:
CNCG_HUMAN (Q13956)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
PDE6H

# Metabolic_Enzyme_3_Geneatlas_id:
PDE6H

# Metabolic_Enzyme_3_hgnc_id:
HGNC:8790

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_3_Gene_Sequence:
>252 bp
ATGAGTGACAACACTACTCTGCCTGCTCCAGCTTCAAACCAGGGTCCTACCACCCCACGC
AAAGGCCCTCCCAAGTTCAAGCAGAGGCAGACTCGCCAATTCAAGAGTAAACCTCCAAAG
AAAGGTGTGAAAGGATTTGGAGATGACATTCCAGGAATGGAGGGGCTAGGAACAGATATC
ACAGTGATTTGTCCATGGGAGGCATTCAGCCACCTGGAATTGCATGAGCTCGCTCAGTTT
GGGATTATCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
D45399

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_3_Locus:
12p13

# Metabolic_Enzyme_3_SNPs:
rs2233628; rs10846103; rs10505783; rs12305014; rs3748304; rs11056268; rs11056266; rs11056264; rs11056267; rs10505784; rs11056265; rs11832908; rs16910453; rs16910452; rs12228166; rs12422943; rs10744079; rs12306284; rs2233623; rs2233624; rs12832328; rs2233627; rs11833894; rs10846101; rs7954788; rs4764144; rs12579539; rs2233615; rs11835506; rs7953827; rs7301508; rs11056262; rs11056263; rs12228802; rs11611992; rs2233614; rs11450989; rs11314271; rs11346506; rs12817970; rs12817527; rs12822730; rs34043026; rs35679948; rs2233626; rs2233625; rs11608901; rs11608900; rs35657741; rs4616093; rs2233619; rs2233617; rs2233618; rs2233620; rs2233616; rs34917153; rs34417895; rs2233622; rs2233621; rs10744080; rs10846096; rs10846097; rs11056256; rs11056257; rs11056258; rs11056259; rs11056260; rs11056261; rs11056269; rs11056271; rs11056272; rs11056273; rs11056274; rs11056275; rs11832957; rs11834072; rs11835380; rs11835890; rs12298310; rs12298374; rs12307651; rs12308864; rs12322752; rs12424815; rs12425797; rs12425846; rs12426974; rs12821630; rs2024506; rs2430717; rs2430718; rs2430719; rs2430720; rs2430722; rs2445431; rs36114797; rs3983696; rs4429114; rs4764145; rs4764146; rs7300467; rs7301780; rs7311989; rs7313555; rs7954364; rs7954390; rs7955907; rs7966504; rs7968954; rs7976617; rs7977013; rs7978415

# Metabolic_Enzyme_3_General_References:
8786098

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5834

# Metabolic_Enzyme_4_Name:
Adenylate kinase isoenzyme 1

# Metabolic_Enzyme_4_Synonyms:
ATP-AMP transphosphorylase; AK1; Myokinase

# Metabolic_Enzyme_4_Gene_Name:
AK1

# Metabolic_Enzyme_4_Protein_Sequence:
>Adenylate kinase isoenzyme 1
MEEKLKKTKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEI
MEKGQLVPLETVLDMLRDAMVAKVNTSKGFLIDGYPREVQQGEEFERRIGQPTLLLYVDA
GPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVD
SVFSQVCTHLDALK

# Metabolic_Enzyme_4_Number_of_Residues:
194

# Metabolic_Enzyme_4_Molecular_Weight:
21635

# Metabolic_Enzyme_4_Theoretical_pI:
8.99

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  adenylate kinase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleotide kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleoside triphosphate metabolism
Process:  purine ribonucleoside triphosphate metabolism
Process:  ATP metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_4_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
This small ubiquitous enzyme is essential for maintenance and cell growth

# Metabolic_Enzyme_4_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_4_Reaction:
ATP + AMP = 2 ADP

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00406:ADK

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.7.4.3

# Metabolic_Enzyme_4_GenBank_ID_Protein:
178322

# Metabolic_Enzyme_4_SwissProt_ID:
KAD1_HUMAN (P00568)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
AK1

# Metabolic_Enzyme_4_Geneatlas_id:
AK1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:361

# Metabolic_Enzyme_4_PDB_ID:
1Z83

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_4_Gene_Sequence:
>585 bp
ATGGAAGAGAAGCTGAAGAAAACCAAGATCATCTTTGTGGTGGGTGGGCCTGGCTCAGGG
AAGGGCACCCAGTGTGAGAAGATCGTGCAGAAGTATGGCTACACCCACCTCTCCACCGGG
GACCTCCTGCGGTCCGAGGTCAGCTCAGGCTCGGCCAGGGGCAAGAAGCTGTCGGAAATC
ATGGAGAAGGGGCAGCTGGTTCCACTGGAGACAGTGTTGGACATGCTCCGGGATGCCATG
GTGGCCAAAGTCAATACTTCCAAAGGCTTCCTGATTGATGGCTACCCGCGGGAGGTGCAG
CAAGGAGAAGAGTTTGAGCGACGGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCA
GGCCCTGAGACCATGACCCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGAC
GACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATTACAAGGCCACAGAACCCGTC
ATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGAC
AGTGTCTTCTCCCAGGTCTGCACCCACCTGGACGCCCTAAAGTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
J04809

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_4_Locus:
9q34.1

# Metabolic_Enzyme_4_SNPs:
rs8192462; rs913987; rs4226; rs1005362; rs10987762; rs1009935; rs1556246; rs3780663; rs2094332; rs743539; rs743537; rs3780662; rs2070692; rs968463; rs913984; rs913985; rs743540; rs743538; rs7031929; rs3780661; rs2070690; rs10987766; rs2070689; rs10987765; rs6478799; rs3758323; rs3758321; rs3758322; rs7032134; rs35902264; rs913986; rs35834000; rs10987763; rs762490; rs2767397; rs11288755; rs5900774; rs34340582; rs2249308; rs2070693; rs11350563; rs2767396; rs5900775; rs762492; rs35738186; rs2767400; rs2010424; rs2767399; rs35921099; rs36059128; rs34076212; rs2767398; rs7018806; rs2070691; rs13290260; rs3842223; rs34920249; rs41305503; rs34525266; rs12342060; rs2767401; rs1009937; rs2010640; rs762491; rs7019406; rs34357982; rs2854237; rs4989853; rs2774265; rs13290737; rs2767395; rs2900257; rs2900258; rs913988; rs13291054; rs1041382; rs35534101; rs2854238; rs13291025; rs13290745; rs5900773; rs35466810; rs12339436; rs35452223; rs1053520; rs10819315; rs11998795; rs1537034; rs1887266; rs1887267; rs2031696; rs3178243; rs4837194; rs4837196; rs4837197; rs4837202; rs7865146; rs913981; rs913982; rs913983; rs9919018

# Metabolic_Enzyme_4_General_References:
183954; 2542324

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5426

# Metabolic_Enzyme_5_Name:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

# Metabolic_Enzyme_5_Synonyms:
E- NPP 3; Phosphodiesterase I/nucleotide pyrophosphatase 3; Phosphodiesterase I beta; PD-Ibeta; CD203c antigen[Includes: Alkaline phosphodiesterase I; NPPase]

# Metabolic_Enzyme_5_Gene_Name:
ENPP3

# Metabolic_Enzyme_5_Protein_Sequence:
>Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFD
ASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCL
QKKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTL
MPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLS
SKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERIS
TLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRN
LHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNS
EEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGG
GNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLN
HLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEI
TATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPT
VPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEE
FRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHY
FVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVR
DVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI

# Metabolic_Enzyme_5_Number_of_Residues:
875

# Metabolic_Enzyme_5_Molecular_Weight:
100097

# Metabolic_Enzyme_5_Theoretical_pI:
6.55

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  nuclease activity
Function:  endonuclease activity
Function:  binding
Function:  nucleic acid binding
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD

# Metabolic_Enzyme_5_Pathway:
map00230  Purine metabolism;
 map00500  Starch and sucrose metabolism;
 map00740  Riboflavin metabolism;
 map00760  Nicotinate and nicotinamide metabolism;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_5_Reaction:
A dinucleotide + H2O = 2 mononucleotides

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01663:Phosphodiest;
PF01033:Somatomedin_B

# Metabolic_Enzyme_5_Signals:
1-38

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.1.4.1;EC 3.6.1.9

# Metabolic_Enzyme_5_GenBank_ID_Protein:
2465540

# Metabolic_Enzyme_5_SwissProt_ID:
ENPP3_HUMAN (O14638)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ENPP3

# Metabolic_Enzyme_5_Geneatlas_id:
ENPP3

# Metabolic_Enzyme_5_hgnc_id:
HGNC:3358

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential). Note=Located to the apical surface in intestinal and kidney epithelial cells. Located to the cell surface of basophils, and to the apical plasma membrane of bile duct cells. Secreted protein. Note=Secreted in serum, and in lumen of epithelial cells

# Metabolic_Enzyme_5_Gene_Sequence:
>2628 bp
ATGGAATCTACGTTGACTTTAGCAACGGAACAACCTGTTAAGAAGAACACTCTTAAGAAA
TATAAAATAGCTTGCATTGTTCTTCTTGCTTTGCTGGTGATCATGTCACTTGGATTAGGC
CTGGGGCTTGGACTCAGGAAACTGGAAAAGCAAGGCAGCTGCAGGAAGAAGTGCTTTGAT
GCATCATTTAGAGGACTGGAGAACTGCCGGTGTGATGTGGCATGTAAAGACCGAGGTGAT
TGCTGCTGGGATTTTGAAGACACCTGTGTGGAATCAACTCGAATATGGATGTGCAATAAA
TTTCGTTGTGGAGAGACCAGATTAGAGGCCAGCCTTTGCTCTTGTTCAGATGACTGTTTG
CAGAAGAAAGATTGCTGTGCTGACTATAAGAGTGTTTGCCAAGGAGAAACCTCATGGCTG
GAAGAAAACTGTGACACAGCCCAGCAGTCTCAGTGCCCAGAAGGGTTTGACCTGCCACCA
GTTATCTTGTTTTCTATGGATGGATTTAGAGCTGAATATTTATACACATGGGATACTTTA
ATGCCAAATATCAATAAACTGAAAACATGTGGAATTCATTCAAAATACATGAGAGCTATG
TATCCTACCAAAACCTTCCCAAATCATTACACCATTGTCACGGGCTTGTATCCAGAGTCA
CATGGCATCATTGACAATAATATGTATGATGTAAATCTCAACAAGAATTTTTCACTTTCT
TCAAAGGAACAAAATAATCCAGCCTGGTGGCATGGGCAACCAATGTGGCTGACAGCAATG
TATCAAGGTTTAAAAGCCGCTACCTACTTTTGGCCCGGATCAGAAGTGGCTATAAATGGC
TCCTTTCCTTCCATATACATGCCTTACAACGGAAGTGTCCCATTTGAAGAGAGGATTTCT
ACACTGTTAAAATGGCTGGACCTGCCCAAAGCTGAAAGACCCAGGTTTTATACCATGTAT
TTTGAAGAACCTGATTCCTCTGGACATGCAGGTGGACCAGTCAGTGCCAGAGTAATTAAA
GCCTTACAGGTAGTAGATCATGCTTTTGGGATGTTGATGGAAGGCCTGAAGCAGCGGAAT
TTGCACAACTGTGTCAATATCATCCTTCTGGCTGACCATGGAATGGACCAGACTTATTGT
AACAAGATGGAATACATGACTGATTATTTTCCCAGAATAAACTTCTTCTACATGTACGAA
GGGCCTGCCCCCCGCATCCGAGCTCATAATATACCTCATGACTTTTTTAGTTTTAATTCT
GAGGAAATTGTTAGAAACCTCAGTTGCCGAAAACCTGATCAGCATTTCAAGCCCTATTTG
ACTCCTGATTTGCCAAAGCGACTGCACTATGCCAAGAACGTCAGAATCGACAAAGTTCAT
CTCTTTGTGGATCAACAGTGGCTGGCTGTTAGGAGTAAATCAAATACAAATTGTGGAGGA
GGCAACCATGGTTATAACAATGAGTTTAGGAGCATGGAGGCTATCTTTCTGGCACATGGA
CCCAGTTTTAAAGAGAAGACTGAAGTTGAACCATTTGAAAATATTGAAGTCTATAACCTA
ATGTGTGATCTTCTACGCATTCAACCAGCACCAAACAATGGAACCCATGGTAGTTTAAAC
CATCTTCTGAAGGTGCCTTTTTATGAGCCATCCCATGCAGAGGAGGTGTCAAAGTTTTCT
GTTTGTGGCTTTGCTAATCCATTGCCCACAGAGTCTCTTGACTGTTTCTGCCCTCACCTA
CAAAATAGTACTCAGCTGGAACAAGTGAATCAGATGCTAAATCTCACCCAAGAAGAAATA
ACAGCAACAGTGAAAGTAAATTTGCCATTTGGGAGGCCTAGGGTACTGCAGAAGAACGTG
GACCACTGTCTCCTTTACCACAGGGAATATGTCAGTGGATTTGGAAAAGCTATGAGGATG
CCCATGTGGAGTTCATACACAGTCCCCCAGTTGGGAGACACATCGCCTCTGCCTCCCACT
GTCCCAGACTGTCTGCGGGCTGATGTCAGGGTTCCTCCTTCTGAGAGCCAAAAATGTTCC
TTCTATTTAGCAGACAAGAATATCACCCACGGCTTCCTCTATCCTCCTGCCAGCAATAGA
ACATCAGATAGCCAATATGATGCTTTAATTACTAGCAATTTGGTACCTATGTATGAAGAA
TTCAGAAAAATGTGGGACTACTTCCACAGTGTTCTTCTTATAAAACATGCCACAGAAAGA
AATGGAGTAAATGTGGTTAGTGGACCAATATTTGATTATAATTATGATGGCCATTTTGAT
GCTCCAGATGAAATTACCAAACATTTAGCCAACACTGATGTTCCCATCCCAACACACTAC
TTTGTGGTGCTGACCAGTTGTAAAAACAAGAGCCACACACCGGAAAACTGCCCTGGGTGG
CTGGATGTCCTACCCTTTATCATCCCTCACCGACCTACCAACGTGGAGAGCTGTCCTGAA
GGTAAACCAGAAGCTCTTTGGGTTGAAGAAAGATTTACAGCTCACATTGCCCGGGTCCGT
GATGTAGAACTTCTCACTGGGCTTGACTTCTATCAGGATAAAGTGCAGCCTGTCTCTGAA
ATTTTGCAACTAAAGACATATTTACCAACATTTGAAACCACTATTTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AF005632

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_5_Locus:
6q22

# Metabolic_Enzyme_5_SNPs:
Not Available

# Metabolic_Enzyme_5_General_References:
9344668; 14574404

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5713

# Metabolic_Enzyme_6_Name:
Beta-Ala-His dipeptidase precursor

# Metabolic_Enzyme_6_Synonyms:
Carnosine dipeptidase 1; CNDP dipeptidase 1; Serum carnosinase; Glutamate carboxypeptidase-like protein 2

# Metabolic_Enzyme_6_Gene_Name:
CNDP1

# Metabolic_Enzyme_6_Protein_Sequence:
>BetaAlaHis dipeptidase precursor
MDPKLGRMAASLLAVLLLLLERGMFSSPSPPPALLEKVFQYIDLHQDEFVQTLKEWVAIE
SDSVQPVPRFRQELFRMMAVAADTLQRLGARVASVDMGPQQLPDGQSLPIPPVILAELGS
DPTKGTVCFYGHLDVQPADRGDGWLTDPYVLTEVDGKLYGRGATDNKGPVLAWINAVSAF
RALEQDLPVNIKFIIEGMEEAGSVALEELVEKEKDRFFSGVDYIVISDNLWISQRKPAIT
YGTRGNSYFMVEVKCRDQDFHSGTFGGILHEPMADLVALLGSLVDSSGHILVPGIYDEVV
PLTEEEINTYKAIHLDLEEYRNSSRVEKFLFDTKEEILMHLWRYPSLSIHGIEGAFDEPG
TKTVIPGRVIGKFSIRLVPHMNVSAVEKQVTRHLEDVFSKRNSSNKMVVSMTLGLHPWIA
NIDDTQYLAAKRAIRTVFGTEPDMIRDGSTIPIAKMFQEIVHKSVVLIPLGAVDDGEHSQ
NEKINRWNYIEGTKLFAAFFLEMAQLH

# Metabolic_Enzyme_6_Number_of_Residues:
507

# Metabolic_Enzyme_6_Molecular_Weight:
56693

# Metabolic_Enzyme_6_Theoretical_pI:
4.95

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  protein dimerization activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  metallopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_6_Pathway:
map00340  Histidine metabolism;
 map00410  beta-Alanine metabolism

# Metabolic_Enzyme_6_Reaction:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF07687:M20_dimer;
PF01546:Peptidase_M20

# Metabolic_Enzyme_6_Signals:
1-26

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.4.13.20

# Metabolic_Enzyme_6_GenBank_ID_Protein:
16555792

# Metabolic_Enzyme_6_SwissProt_ID:
CNDP1_HUMAN (Q96KN2)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
CNDP1

# Metabolic_Enzyme_6_Geneatlas_id:
CNDP1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:20675

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_6_Gene_Sequence:
>1527 bp
ATGGATCCCAAACTCGGGAGAATGGCTGCGTCCCTGCTGGCTGTGCTGCTGCTGCTGCTG
CTGGAGCGCGGCATGTTCTCCTCACCCTCCCCGCCCCCGGCGCTGTTAGAGAAAGTCTTC
CAGTACATTGACCTCCATCAGGATGAATTTGTGCAGACGCTGAAGGAGTGGGTGGCCATC
GAGAGCGACTCTGTCCAGCCTGTGCCTCGCTTCAGACAAGAGCTCTTCAGAATGATGGCC
GTGGCTGCGGACACGCTGCAGCGCCTGGGGGCCCGTGTGGCCTCGGTGGACATGGGTCCT
CAGCAGCTGCCCGATGGTCAGAGTCTTCCAATACCTCCCGTCATCCTGGCCGAACTGGGG
AGCGATCCCACGAAAGGCACCGTGTGCTTCTACGGCCACTTGGACGTGCAGCCTGCTGAC
CGGGGCGATGGGTGGCTCACGGACCCCTATGTGCTGACGGAGGTAGGCGGGAAACTTTAT
GGACGAGGAGCGACCGACAACAAAGGCCCTGTCTTGGCTTGGATCAATGCTGTGAGCGCC
TTCAGAGCCCTGGAGCAAGATCTTCCTGTGAATATCAAATTCATCATTGAGGGGATGGAA
GAGGCTGGCTCTGTTGCCCTGGAGGAACTTGTGGAAAAAGAAAAGGACCGATTCTTCTCT
GGTGTGGACTACATTGTAATTTCAGATAACCTGTGGATCAGCCAAAGGAAGCTAGCAATC
ACTTACGGAACCCGGGGGAACAGCTACTTCATGGTGGAGGTGAAATGCAGAGACCAGGAT
TTTCACTCAGGAACCTTTGGTGGCATCCTTCATGAACTAATGGCTGATCTGGTTGCTCTT
CTCGGTAGCCTGGTAGACTCGTCTGGTCATATCCTGGTCCCTGGAATCTATGATGAAGTG
GTTCCTCTTACAGAAGAGGAAATAAATACATACAAAGCCATCCATCTAGACCTAGAAGAA
TACCGGAATAGCAGCCGGGTTGAGAAATTTCTGTTCGATACTAAGGAGGAGATTCTAATG
CACCTCTGGAGGTACCCATCTCTTTCTATTCATGGGATCGAGGGCGCGTTTGATGAGCCT
GGAACTAAAACAGTCATACCTGGCCGAGTTATAGGAAAATTTTCAATCCGTCTAGTCCCT
CACATGAATGTGTCTGCGGTGGAAAAACAGGTGACACGACATCTTGAAGATGTGTTCTCC
AAAAGAAATAGTTCCAACAAGATGGTTGTTTCCATGACTCTAGGACTACACCCGTGGATT
GCAAATATTGATGACACTCAGTATCTCGCAGCAAAAAGAGCGATCAGAACAGTGTTTGGA
ACAGAACCAGATATGATCCGGGATGGATCCACCATTCCAATTGCCAAAATGTTCCAGGAG
ATCGTCCACAAGAGCGTGGTGCTAATTCCGCTGGGAGCTGTTGATGATGGAGAACATTCG
CAGAATGAGAAAATCAACAGGTGGAACTACATAGAGGGAACCAAATTATTTGCTGCCTTT
TTCTTAGAGATGGCCCAGCTCCATTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AJ417564

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:18

# Metabolic_Enzyme_6_Locus:
18q22.3

# Metabolic_Enzyme_6_SNPs:
rs4263028; rs11151964; rs9807352; rs12960862; rs2887; rs4891564; rs2346064; rs1004453; rs7239132; rs12604675; rs10469123; rs10469203; rs12607796; rs12605490; rs8087768; rs9319909; rs4892246; rs7506171; rs4329999; rs7242384; rs8085167; rs11876996; rs7244370; rs7506929; rs4892243; rs7231312; rs4892242; rs12605520; rs733686; rs9967490; rs7229005; rs7232853; rs1426256; rs7506957; rs17817095; rs11875756; rs7506825; rs17817180; rs12961730; rs12964027; rs12456406; rs12964208; rs7506760; rs12956997; rs12456388; rs12964454; rs11873844; rs17817345; rs7505047; rs17089382; rs17089414; rs17089390; rs7233066; rs9953129; rs9960024; rs11659237; rs9807248; rs11662276; rs17816861; rs11873901; rs10469124; rs17089403; rs1559809; rs17817077; rs9949100; rs4891563; rs11661606; rs2881289; rs7228575; rs9957229; rs9955944; rs17089375; rs4892244; rs17089411; rs4892239; rs17238585; rs7505555; rs12326826; rs9946796; rs11876764; rs9949990; rs34570315; rs12957330; rs7506936; rs4892241; rs7506258; rs9952652; rs4355018; rs9957885; rs11664748; rs4133234; rs17238285; rs1974965; rs11659364; rs4892238; rs11875122; rs7237549; rs9948919; rs12959707; rs12457983; rs12964810; rs1974963; rs4891562; rs11873542; rs12962343; rs2881288; rs17089378; rs12954161; rs9959794; rs7504932; rs12327522; rs11664535; rs7230673; rs12455650; rs1974964; rs7244647; rs9989559; rs11875810; rs12954438; rs2098910; rs2346061; rs2346063; rs890333; rs2346062; rs2081548; rs890332; rs11538620; rs34522443; rs11538622; rs11538624; rs11538623; rs35604255; rs10533212; rs35771415; rs34713611; rs9967349; rs33922160; rs34365714; rs34526667; rs11875787; rs28448542; rs28871039; rs35084313; rs10549931; rs10685765; rs34874693; rs4891561; rs12606902; rs34117300; rs12959038; rs36228963; rs5826336; rs35735348; rs34499247; rs35885130; rs35388041; rs28713380; rs11151965; rs34138697; rs35204551; rs9966983; rs7505007; rs35096494; rs33950634; rs33981863; rs34142328; rs12959706; rs9955580; rs9947243; rs34869467; rs35788286; rs10624462; rs34283867; rs6566813; rs34962477; rs34335073; rs5826332; rs36060345; rs34573470; rs35682790; rs35362460; rs35860275; rs35365788; rs12964034; rs10522670; rs12959748; rs4892245; rs36111704; rs12969794; rs5826335; rs4891560; rs9965945; rs34070364; rs10624665; rs5826334; rs34842524; rs35877440; rs34785330; rs17089373; rs7233122; rs10596720; rs9948674; rs34189472; rs10562152; rs10649703; rs34321505; rs35707511; rs9949211; rs35368997; rs35691581; rs35734110; rs9953867; rs34563384; rs35469246; rs8087111; rs34726849; rs35932028; rs12969795; rs12969769; rs34799288; rs35234907; rs28800835; rs34646410; rs10685766; rs34895018; rs35597919; rs12961586; rs6566814; rs28877095; rs4892240; rs33911381; rs8088199; rs11872770; rs36206459; rs7350982; rs34145828; rs11447097; rs12104001; rs4892247; rs3080879; rs10663835; rs10871736; rs10871737; rs1130046; rs11664131; rs12327049; rs12456405; rs12954579; rs12966495; rs12967519; rs12970020; rs17089369; rs2114228; rs28534519; rs35248661; rs4353545; rs4891565; rs4891566; rs4892233; rs4892248; rs4892249; rs6566815; rs7238101; rs7504377; rs7506051; rs7506112; rs8096427; rs8099458; rs9319908

# Metabolic_Enzyme_6_General_References:
12975309

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5836

# Metabolic_Enzyme_7_Name:
Ubiquitin/ISG15-conjugating enzyme E2 L6

# Metabolic_Enzyme_7_Synonyms:
Ubiquitin- protein ligase L6; Ubiquitin carrier protein L6; UbcH8; Retinoic acid-induced gene B protein; RIG-B

# Metabolic_Enzyme_7_Gene_Name:
UBE2L6

# Metabolic_Enzyme_7_Protein_Sequence:
>Ubiquitin/ISG15conjugating enzyme E2 L6
MASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPEY
PFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREPL
RMDLADLLTQNPELFRKNAEEFTLRFGVDRPS

# Metabolic_Enzyme_7_Number_of_Residues:
152

# Metabolic_Enzyme_7_Molecular_Weight:
17638

# Metabolic_Enzyme_7_Theoretical_pI:
8.06

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53

# Metabolic_Enzyme_7_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_7_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_7_GenBank_ID_Protein:
2623260

# Metabolic_Enzyme_7_SwissProt_ID:
UB2L6_HUMAN (O14933)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
UBE2L6

# Metabolic_Enzyme_7_Geneatlas_id:
UBE2L6

# Metabolic_Enzyme_7_hgnc_id:
HGNC:12490

# Metabolic_Enzyme_7_PDB_ID:
1WZW

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>459 bp
ATGGCGAGCATGCGAGTGGTGAAGGAGCTGGAGGATCTTCAGAAGAAGCCTCCCCCATAC
CTGCGGAACCTGTCCAGCGATGATGCCAATGTCCTGGTGTGGCACGCTCTCCTCCTACCC
GACCAACCTCCCTACCACCTGAAAGCCTTCAACCTGCGCATCAGCTTCCCGCCGGAGTAT
CCGTTCAAGCCTCCCATGATCAAATTCACAACCAAGATCTACCACCCCAACGTGGACGAG
AACGGACAGATTTGCCTGCCCATCATCAGCAGTGAGAACTGGAAGCCTTGCACCAAGACT
TGCCAAGTCCTGGAGGCCCTCAATGTGCTGGTGAATAGACCGAATATCAGGGAGCCCCTG
CGGATGGACCTCGCTGACCTGCTGACACAGAATCCGGAGCTGTTCAGAAAGAATGCCGAA
GAGTTCACCCTCCGATTCGGAGTGGACCGGCCCTCCTAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AF031141

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_7_Locus:
11q12

# Metabolic_Enzyme_7_SNPs:
rs2649649; rs5847; rs2729374; rs2729372; rs4938871; rs2848621; rs1115172; rs2649650; rs2649651; rs2848624; rs2234405; rs11604188; rs1115173; rs2848623; rs4939152; rs12291920; rs3741083; rs2729375; rs7482188; rs7105312; rs4939151; rs11229057; rs10792104; rs2729373; rs10896626; rs12364489; rs2234412; rs2649656; rs2234409; rs2649655; rs2729371; rs11603817; rs2729370; rs35921478; rs1802110; rs2234408; rs3741082; rs12292224; rs2649652; rs35985517; rs11554063; rs34890600; rs1798164; rs475215; rs11605528; rs34002509; rs568190; rs2649653; rs35614262; rs2848625; rs10624657; rs35528044; rs2270765; rs34323359; rs11301277; rs11605571; rs12800738; rs35413834; rs34749631; rs2649654; rs35011093; rs11229056; rs1115174; rs11604761; rs11554065; rs35993405; rs2234406; rs2649647; rs14889; rs2234407; rs11554064; rs12800733; rs1058468; rs2649648; rs2234410; rs2234411; rs35662521; rs5792049; rs17525265; rs10680002; rs2234404; rs35789692; rs34156168; rs2234402; rs2649646; rs2234403; rs10657575; rs10629551; rs12291337; rs35305272; rs2234401; rs10792106; rs1124942; rs12223229; rs2649658; rs2729364; rs2729367; rs2729368; rs2729382; rs2848639; rs7124330

# Metabolic_Enzyme_7_General_References:
9153201; 10894956

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5837

# Metabolic_Enzyme_8_Name:
Glycyl-tRNA synthetase

# Metabolic_Enzyme_8_Synonyms:
Glycine--tRNA ligase; GlyRS

# Metabolic_Enzyme_8_Gene_Name:
GARS

# Metabolic_Enzyme_8_Protein_Sequence:
>GlycyltRNA synthetase
MPSPRPVLLRGARAALLLLLPPRLLARPSLLLRRSLSAASCAPISLPAAASRSSMDGAGA
EEVLAPLRLAVRQQGDLVRKLKEDKAPQVDVDKAVAELKARKRVLEAKELALQPKDDIVD
RAKMEDTLKRRFFYDQAFAIYGGVSGLYDFGPVGCALKNNIIQTWRQHFIQEEQILEIDC
TMLTPEPVLKTSGHVDKFADFMVKDVKNGECFRADHLLKAHLQKLMSDKKCSVEKKSEME
SVLAQLDNYGQQELADLFVNYNVKSPITGNDLSPPVSFNLMFKTFIGPGGNMPGYLRPET
AQGIFLNFKRLLEFNQGKLPFAAAQIGNSFRNEISPRSGLIRVREFTMAEIEHFVDPSEK
DHPKFQNVADLHLYLYSAKAQVSGQSARKMRLGDAVEQGVINNTVLGYFIGRIYLYLTKV
GISPDKLRFRQHMENEMAHYACDCWDAESKTSYGWIEIVGCADRSCYDLSCHARATKVPL
VAEKPLKEPKTVNVVQFEPSKGAIGKAYKKDAKLVMEYLAICDECYITEMEMLLNEKGEF
TIETEGKTFQLTKDMINVKRFQKTLYVEEVVPNVIEPSFGLGRIMYTVFEHTFHVREGDE
QRTFFSFPAVVAPFKCSVLPLSQNQEFMPFVKELSEALTRHGVSHKVDDSSGSIGRRYAR
TDEIGVAFGVTIDFDTVNKTPHTATLRDRDSMRQIRAEISELPSIVQDLANGNITWADVE
ARYPLFEGQETGKKETIEE

# Metabolic_Enzyme_8_Number_of_Residues:
739

# Metabolic_Enzyme_8_Molecular_Weight:
83140

# Metabolic_Enzyme_8_Theoretical_pI:
7.04

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  glycine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  glycyl-tRNA aminoacylation
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  protein biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_8_Specific_Function:
ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)

# Metabolic_Enzyme_8_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_8_Reaction:
ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF03129:HGTP_anticodon;
PF00587:tRNA-synt_2b;
PF00458:WHEP-TRS

# Metabolic_Enzyme_8_Signals:
1-26

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 6.1.1.14

# Metabolic_Enzyme_8_GenBank_ID_Protein:
1311463

# Metabolic_Enzyme_8_SwissProt_ID:
SYG_HUMAN (P41250)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
GARS

# Metabolic_Enzyme_8_Geneatlas_id:
GARS

# Metabolic_Enzyme_8_hgnc_id:
HGNC:4162

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Not Available

# Metabolic_Enzyme_8_Gene_Sequence:
>2220 bp
ATGCCCTCTCCGCGTCCAGTGCTGCTTAGAGGTGCTCGCGCCGCTCTGCTGCTGCTGCTG
CCGCCCCGGCTCTTAGCCCGACCCTCGCTCCTGCTCCGCCGGTCCCTCAGCGCGGCCTCC
TGCGCCCCGATCTCCTTGCCCGCCGCCGCCTCCCGGAGCAGCATGGACGGCGCGGGGGCT
GAGGAGGTGCTGGCACCTCTGAGGCTAGCAGTGCGCCAGCAGGGAGATCTTGTGCGAAAA
CTCAAAGAAGATAAAGCACCCCAAGTAGACGTAGACAAAGCAGTGGCTGAGCTCAAAGCC
CGCAAGAGGGTTCTGGAAGCAAAGGAGCTGGCGTTACAGCCCAAAGATGATATTGTAGAC
CGAGCAAAAATGGAAGATACCCTGAAGAGGAGGTTTTTCTATGATCAAGCTTTTGCTATT
TATGGAGGTGTTAGTGGTCTGTATGACTTTGGGCCAGTTGGCTGTGCTTTGAAGAACAAT
ATTATTCAGACCTGGAGGCAGCACTTTATCCAAGAGGAACAGATCCTGGAGATCGATTGC
ACCATGCTCACCCCTGAGCCAGTTTTAAAGACCTCTGGCCATGTAGACAAATTTGCTGAC
TTCATGGTGAAAGACGTAAAAAATGGAGAATGTTTTCGTGCTGACCATCTATTAAAAGCT
CATTTACAGAAATTGATGTCTGATAAGAAGTGTTCTGTCGAAAAGAAATCAGAAATGGAA
AGTGTTTTGGCCCAGCTTGATAACTATGGACAGCAAGAACTTGCGGATCTTTTTGTGAAC
TATAATGTAAAATCTCCCATTACTGGAAATGATCTATCCCCTCCAGTGTCTTTTAACTTA
ATGTTCAAGACTTTCATTGGGCCTGGAGGAAACATGCCTGGGTACTTGAGACCAGAAACT
GCACAGGGGATTTTCTTGAATTTCAAACGACTTTTGGAGTTCAACCAAGGAAAGTTGCCT
TTTGCTGCTGCCCAGATTGGAAATTCTTTTAGAAATGAGATCTCCCCTCGATCTGGACTG
ATCAGAGTCAGAGAATTCACAATGGCAGAAATTGAGCACTTTGTAGATCCCAGTGAGAAA
GACCACCCCAAGTTCCAGAATGTGGCAGACCTTCACCTTTATTTGTATTCAGCAAAAGCC
CAGGTCAGCGGACAGTCCGCTCGGAAAATGCGCCTGGGAGATGCTGTTGAACAGGGTGTG
ATTAATAACACAGTATTAGGCTATTTCATTGGCCGCATCTACCTCTACCTCACGAAGGTT
GGAATATCTCCAGATAAACTCCGCTTCCGGCAGCACATGGAGAATGAGATGGCCCATTAT
GCCTGTGACTGTTGGGATGCAGAATCCAAAACATCCTACGGTTGGATTGAGATTGTTGGA
TGTGCTGATCGTTCCTGTTATGACCTCTCCTGTCATGCACGAGCCACCAAAGTCCCACTT
GTAGCTGAGAAACCTCTGAAAGAACCCAAAACAGTCAATGTTGTTCAGTTTGAACCCAGT
AAGGGAGCAATTGGTAAGGCATATAAGAAGGATGCAAAACTGGTGATGGAGTATCTTGCC
ATTTGTGATGAGTGCTACATTACAGAAATGGAGATGCTGCTGAATGAGAAAGGGGAATTC
ACAATTGAAACTGAAGGGAAAACATTTCAGTTAACAAAAGACATGATCAATGTGAAGAGA
TTCCAGAAAACACTATATGTGGAAGAAGTTGTTCCGAATGTAATTGAACCTTCCTTCGGC
CTGGGTAGGATCATGTATACGGTATTTGAACATACATTCCATGTACGAGAAGGAGATGAA
CAGAGAACATTCTTCAGTTTCCCTGCTGTAGTTGCTCCATTCAAATGTTCCGTCCTCCCA
CTGAGCCAAAACCAGGAGTTCATGCCATTTGTCAAGGAATTATCGGAAGCCCTGACCAGG
CATGGAGTATCTCACAAAGTAGACGATTCCTCTGGGTCAATCGGAAGGCGCTATGCCAGG
ACTGATGAGATTGGCGTGGCTTTTGGTGTCACCATTGACTTTGACACAGTGAACAAGACC
CCCCACACTGCAACTCTGAGGGACCGTGACTCAATGCGGCAGATAAGAGCAGAGATCTCT
GAGCTGCCCAGCATAGTCCAAGACCTAGCCAATGGCAACATCACATGGGCTGATGTGGAG
GCCAGGTATCCTCTGTTTGAAGGGCAAGAGACTGGTAAAAAAGAGACAATCGAGGAATGA


# Metabolic_Enzyme_8_GenBank_ID_Gene:
D30658

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_8_Locus:
7p15

# Metabolic_Enzyme_8_SNPs:
rs17159287; rs34886142; rs17159306; rs7808770; rs3886641; rs11553502; rs1049402; rs2970504; rs2529438; rs1468402; rs2709806; rs2527880; rs728539; rs12532057; rs2709778; rs2529439; rs11981106; rs2709809; rs2240401; rs11979352; rs6945035; rs722423; rs10951271; rs758000; rs10239660; rs2527878; rs2527879; rs10249885; rs6462214; rs1558064; rs10487699; rs2893390; rs10487700; rs3807632; rs10265589; rs1986756; rs13228758; rs6970807; rs17159291; rs10280491; rs2240400; rs2709772; rs16875290; rs10233132; rs13228097; rs17159273; rs17159275; rs6950015; rs11980069; rs2072236; rs17159267; rs10239537; rs11982890; rs6947982; rs17159289; rs2074779; rs11976576; rs17159279; rs17159296; rs11761080; rs2529441; rs17159280; rs2529442; rs2952804; rs6945223; rs17159272; rs2270025; rs2214837; rs11553498; rs1049399; rs11553503; rs17159262; rs35302357; rs3807633; rs35241091; rs3840589; rs34230821; rs11465024; rs35711502; rs34957085; rs34725384; rs13228094; rs2240501; rs41275991; rs34457367; rs6945546; rs10229836; rs35151755; rs34785207; rs2709771; rs34149226; rs10264469; rs6945475; rs1986757; rs3840588; rs6945586; rs41275988; rs36125163; rs35425165; rs34885661; rs13226718; rs35821025; rs2952805; rs35482863; rs34495080; rs11454228; rs13228006; rs34668775; rs2893388; rs35045679; rs2190241; rs2893389; rs4000210; rs10243040; rs10249882; rs11983525; rs12667790; rs13232935; rs16875282; rs16875285; rs1859644; rs2529437; rs38494; rs38497; rs38498; rs39739; rs4266550; rs4526262; rs6956054; rs7791663; rs7809256; rs7810227

# Metabolic_Enzyme_8_General_References:
7962006; 7753621; 7961834

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5838

# Metabolic_Enzyme_9_Name:
Ribose-phosphate pyrophosphokinase III

# Metabolic_Enzyme_9_Synonyms:
Phosphoribosyl pyrophosphate synthetase III; PRS-III; Phosphoribosyl pyrophosphate synthetase 1-like 1

# Metabolic_Enzyme_9_Gene_Name:
PRPS1L1

# Metabolic_Enzyme_9_Protein_Sequence:
>Ribosephosphate pyrophosphokinase 
IIIMPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIDESVRGEDVYIVQ
SGCGEINDSLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRSPISAKLVANMLS
IAGADHIITMDLHASQIQGFFDIPVDNLYAEPTVLKWIRENIPEWKNCIIVSPDAGGAKR
VTSIADQLNVDFALIHKERKKANEVDCIVLVGDVNDRVAILVDDMADTCVTICLAADKLL
SAGATRVYAILTHGIFSGPAISRINTACFEAVVVTNTIPQDEKMKHCSKIRVIDISMILA
EAIRRTHNGESVSYLFSHVPL

# Metabolic_Enzyme_9_Number_of_Residues:
318

# Metabolic_Enzyme_9_Molecular_Weight:
34840

# Metabolic_Enzyme_9_Theoretical_pI:
6.31

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  lipoate-protein ligase activity
Function:  lipoate-protein ligase B activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  diphosphotransferase activity
Function:  ribose phosphate diphosphokinase activity
 ||
>>>
Process:  nucleotide biosynthesis
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleoside monophosphate metabolism
Process:  nucleoside monophosphate biosynthesis
Process:  ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
ATP + D-ribose 5-phosphate = AMP + 5-phospho- alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_9_Pathway:
map00030  Pentose phosphate pathway;
 map00230  Purine metabolism

# Metabolic_Enzyme_9_Reaction:
ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00156:Pribosyltran

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.7.6.1

# Metabolic_Enzyme_9_GenBank_ID_Protein:
190522

# Metabolic_Enzyme_9_SwissProt_ID:
PRPS3_HUMAN (P21108)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
PRPS1L1

# Metabolic_Enzyme_9_Geneatlas_id:
PRPS1L1

# Metabolic_Enzyme_9_hgnc_id:
HGNC:9463

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Not Available

# Metabolic_Enzyme_9_Gene_Sequence:
>957 bp
ACGCCGAATATCAAAATCTTCAGCGGCAGCTCCCACCAGGACTTATCCCAGAAAATTGCT
GACCGCCTGGGCCTGGAGCTAGGCAAGGTGGTGACTAAGAAATTCAGCAACCAGGAGACC
TGCGTGGAAATTGATGAGAGTGTGCGTGGAGAGGATGTCTACATCGTTCAGAGTGGTTGT
GGCGAAATCAACGACAGTCTAATGGAGCTTTTGATCATGATTAATGCCTGCAAGATTGCT
TCAGCTAGCCGAGTTACTGCAGTCATCCCATGCTTCCCTTATGCCCGACAGGATAAGAAG
GATAAGAGCCGGTCCCCAATCTCTGCCAAGCTTGTTGCAAATATGCTCTCTATAGCAGGT
GCGGATCATATCATCACCATGGACCTACATGCTTCTCAAATTCAGGGCTTTTTTGATATC
CCAGTAGACAACTTGTATGCAGAGCCAACTGTCCTGAAGTGGATAAGGGAGAATATCCCT
GAGTGGAAGAACTGCATTATTGTCTCGCCAGATGCTGGTGGAGCTAAAAGAGTGACCTCC
ATTGCAGACCAGTTGAATGTGGACTTTGCTTTGATTCATAAAGAACGGAAGAAGGCCAAT
GAAGTGGACTGCATAGTGCTAGTGGGAGATGTGAATGATCGTGTGGCTATCCTTGTAGAT
GACATGGCAGACACTTGTGTTACAATCTGCCTCGCAGCTGACAAACTTCTCTCAGCTGGA
GCAACCAGAGTTTATGCTATCTTGACTCATGGAATCTTTTCTGGCCCAGCCATTTCTCGC
ATCAACACTGCATGCTTTGAAGCAGTGGTAGTCACCAATACCATACCTCAAGATGAGAAG
ATGAAGCATTGCTCCAAAATACGAGTAATTGACATCTCCATGATCCTTGCAGAAGCCATA
AGGAGAACTCATAATGGGGAATCTGTTTCCTACCTGTTCAGCCATGTTCCTTTATAA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
M57423

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_9_Locus:
7p21.1

# Metabolic_Enzyme_9_SNPs:
rs3800962; rs3800961; rs7780180; rs7803591; rs12668788; rs12699957; rs12666668; rs12672880; rs12673527; rs6461371; rs13231261; rs1126434; rs1126437; rs13231476; rs35708479; rs35797266; rs6946658; rs6978339; rs35289138; rs6946544; rs7800497; rs7784246; rs10950697; rs13226748; rs4236293; rs4555993; rs4555994; rs4618585; rs6953082; rs6962130; rs6962299; rs6963707; rs6974404; rs6975848; rs6976627; rs6976951; rs7781217; rs7781290; rs7800421

# Metabolic_Enzyme_9_General_References:
2168892

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5839

# Metabolic_Enzyme_10_Name:
Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase

# Metabolic_Enzyme_10_Synonyms:
Glutamate--tRNA ligase; Prolyl-tRNA synthetase; Proline--tRNA ligase]

# Metabolic_Enzyme_10_Gene_Name:
EPRS

# Metabolic_Enzyme_10_Protein_Sequence:
>Bifunctional aminoacyltRNA synthetase Includes: GlutamyltRNA synthetase
MEHTEIDHWLEFSATKLSSCDSFTSTINELNHCLSLRTYLVGNSLSLADLCVWATLKGNA
AWQEQLKQKKAPVHVKRWFGFLEAQQAFQSVGTKWDVSTTKARVAPEKKQDVGKFVELPG
AEMGKVTVRFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEKEDFEKVI
LEDVAMLHIKPDQFTYTSDHFETIMKYAEKLIQEGKAYVDDTPAEQMKAEREQRIESKHR
KNPIEKNLQMWEEMKKGSQFGHSCCLRAKIDMSSNNGCMRDPTLYRCKIQPHPRTGNKYN
VYPTYDFACPIVDSIEGVTHALRTTEYHDRDEQFYWIIEALGIRKPYIWEYSRLNLNNTV
LSKRKLTWFVNEGLVDGWDDPRFPTVRGVLRRGMTVEGLKQFIAAQGSSRSVVNMEWDKI
WAFNKKVIDPVAPRYVALLKKEVIPVNVPEAQEEMKEVAKHPKNPEVGLKPVWYSPKVFI
EGADAETFSEGEMVTFINWGNLNITKIHKNADGKIISLDAKFNLENKDYKKTTKVTWLAE
TTHALPIPVICVTYEHLITKPVLGKDEDFKQYVNKNSKHEELMLGDPCLKDLKKGDIIQL
QRRGFFICDQPYEPVSPYSCKEAPCVLIYIPDGHTKEMPTSGSKEKTKVEATKNETSAPF
KERPTPSLNNNCTTSEDSLVLYNRVAVQGDVVRELKAKKAPKEDVDAAVKQLLSLKAEYK
EKTGQEYKPGNPPAEIGQNISSNSSASILESKSLYDEVAAQGEVVRKLKAEKSPKAKINE
AVECLLSLKAQYKEKTGKEYIPGQPPLSQSSDSSPTRNSEPAGLETPEAKVLFDKVASQG
EVVRKLKTEKAPKDQVDIAVQELLQLKAQYKSLIGVEYKPVSATGAEDKDKKKKEKENKS
EKQNKPQKQNDGQRKDPSKNQGGGLSSSGAGEGQGPKKQTRLGLEAKKEENLADWYSQVI
TKSEMIEYHDISGCYILRPWAYAIWEAIKDFFDAEIKKLGVENCYFPMFVSQSALEKEKT
HVADFAPEVAWVTRSGKTELAEPIAIRPTSETVMYPAYAKWVQSHRDLPIKLNQWCNVVR
WEFKHPQPFLRTREFLWQEGHSAFATMEEAAEEVLQILDLYAQVYEELLAIPVVKGRKTE
KEKFAGGDYTTTIEAFISASGRAIQGGTSHHLGQNFSKMFEIVFEDPKIPGEKQFAYQNS
WGLTTRTIGVMTMVHGDNMGLVLPPRVACVQVVIIPCGITNALSEEDKEALIAKCNDYRR
RLLSVNIRVRADLRDNYSPGWKFNHWELKGVPIRLEVGPRDMKSCQFVAVRRDTGEKLTV
AENEAETKLQAILEDIQVTLFTRASEDLKTHMVVANTMEDFQKILDSGKIVQIPFCGEID
CEDWIKKTTARDQDLEPGAPSMGAKSLCIPFKPLCELQPGAKCVCGKNPAKYYTLFGRSY


# Metabolic_Enzyme_10_Number_of_Residues:
1440

# Metabolic_Enzyme_10_Molecular_Weight:
163028

# Metabolic_Enzyme_10_Theoretical_pI:
7.75

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  proline-tRNA ligase activity
Function:  glutamate-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  prolyl-tRNA aminoacylation
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  glutamyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  protein biosynthesis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_10_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_10_Specific_Function:
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)

# Metabolic_Enzyme_10_Pathway:
map00251  Glutamate metabolism;
 map00860  Porphyrin and chlorophyll metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_10_Reaction:
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF03129:HGTP_anticodon;
PF09180:ProRS-C_1;
PF00749:tRNA-synt_1c;
PF03950:tRNA-synt_1c_C;
PF00587:tRNA-synt_2b;
PF00458:WHEP-TRS

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 6.1.1.17;EC 6.1.1.15

# Metabolic_Enzyme_10_GenBank_ID_Protein:
31958

# Metabolic_Enzyme_10_SwissProt_ID:
SYEP_HUMAN (P07814)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
EPRS

# Metabolic_Enzyme_10_Geneatlas_id:
EPRS

# Metabolic_Enzyme_10_hgnc_id:
HGNC:3418

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Not Available

# Metabolic_Enzyme_10_Gene_Sequence:
>4323 bp
ATGGAACATACTGAGATTGATCACTGGTTGGAGTTCAGTGCTACAAAATTATCTTCATGT
GATTCCTTTACTTCTACAATTAATGAACTCAATCATTGCCTGTCTCTGAGAACATACTTA
GTTGGAAACTCCTTGAGTTTAGCAGATTTATGTGTTTGGGCCACCCTAAAAGGAAATGCT
GCCTGGCAAGAACAGTTGAAACAGAAGAAAGCTCCAGTTCATGTAAAACGTTGGTTTGGC
TTTCTTGAAGCCCAGCAGGCCTTCCAGTCAGTAGGTACCAAGTGGGATGTTTCAACAACC
AAAGCTCGAGTGGCACCTGAGAAAAAGCAAGATGTTGGGAAATTTGTTGAGCTTCCAGGT
GCGGAGATGGGAAAGGTTACCGTCAGATTTCCTCCAGAGGCCAGTGGTTACTTACACATT
GGGCATGCAAAAGCTGCTCTTCTGAACCAGCACTACCAGGTTAACTTTAAAGGGAAACTG
ATCATGAGATTTGATGACACAAATCCTGAAAAAGAAAAGGAAGATTTTGAGAAGGTTATC
TTGGAAGATGTTGCAATGTTGCATATCAAACCAGATCAATTTACTTATACTTCGGATCAT
TTTGAAACTATAATGAAGTATGCAGAGAAGCTAATTCAAGAAGGGAAGGCTTATGTGGAT
GATACTCCTGCTGAACAGATGAAAGCAGAACGTGAGCAGAGGATAGAATCTAAACATAGA
AAAAACCCTATTGAGAAGAATCTACAAATGTGGGAAGAAATGAAAAAAGGGAGCCAGTTT
GGTCACTCCTGTTGTTTGCGAGCAAAAATTGACATGAGTAGTAACAATGGATGCATGAGA
GATCCAACCCTTTATCGCTGCAAAATTCAACCACATCCAAGAACTGGAAATAAATACAAT
GTTTATCCAACATATGATTTTGCCTGCCCCATAGTTGACAGCATCGAAGGTGTTACACAT
GCCCTGAGAACAACAGAATACCATGACAGAGATGAGCAGTTTTACTGGATTATTGAAGCT
TTAGGCATAAGAAAACCATATATTTGGGAATATAGTCGGCTAAATCTCAACAACACAGTG
CTATCCAAAAGAAAACTCACATGGTTTGTCAATGAAGGACTAGTAGATGGATGGGATGAC
CCAAGATTTCCTACGGTTCGTGGTGTACTGAGAAGAGGGATGACAGTTGAAGGACTGAAA
CAGTTTATTGCTGCTCAGGGCTCCTCACGTTCAGTCGTGAACATGGAGTGGGACAAAATC
TGGGCGTTTAACAAAAAGGTTATTGACCCAGTGGCTCCACGATATGTTGCATTACTGAAG
AAAGAAGTGATCCCAGTGAATGTACCTGAAGCTCAGGAGGAGATGAAAGAAGTAGCCAAA
CACCCAAAGAATCCTGAGGTTGGCTTGAAGCCTGTGTGGTATAGTCCCAAAGTTTTCATT
GAAGGTGCTGATGCAGAGACTTTTTCGGAGGGTGAGATGGTTACATTTATAAATTGGGGC
AACCTCAACATTACAAAAATACACAAAAATGCAGATGGAAAAATCATATCTCTTGATGCA
AAGTTTAATTTGGAAAACAAAGACTACAAGAAAACCACTAAGGTCACTTGGCTTGCAGAG
ACTACACATGCTCTTCCTATTCCAGTAATCTGTGTCACTTATGAGCACTTGATCACAAAG
CCAGTGCTAGGAAAAGACGAGGACTTTAAGCAGTATGTCAACAAGAACAGTAAGCATGAA
GAGCTAATGCTAGGGGATCCCTGCCTTAAGGATTTGAAAAAAGGAGATATTATACAACTC
CAGAGAAGAGGATTCTTCATATGTGATCAACCTTATGAACCTGTTAGCCCATATAGTTGC
AAGGAAGCCCCGTGTGTTTTGATATACATTCCTGATGGGCACACAAAGGAAATGCCAACA
TCAGGGTCAAAGGAAAAGACCAAAGTAGAAGCCACAAAAAATGAGACCTCTGCTCCTTTT
AAGGAAAGACCAACACCTTCTCTGAATAATAATTGTACTACATCTGAGGATTCCTTGGTC
CTTTACAATAGAGTGGCTGTTCAAGGAGATGTGGTTCGTGAATTAAAAGCCAAGAAAGCA
CCAAAGGAAGATGTAGATGCAGCTGTAAAACAGCTTTTGTCTTTGAAAGCTGAATATAAG
GAGAAAACTGGCCAGGAATATAAACCTGGAAACCCTCCTGCTGAAATAGGACAGAATATT
TCTTCTAATTCCTCAGCAAGTATTCTGGAAAGTAAATCTCTGTATGATGAAGTTGCTGCA
CAAGGGGAGGTGGTTCGTAAGCTAAAAGCTGAAAAATCCCCTAAGGCTAAAATAAATGAA
GCTGTAGAATGCTTACTGTCCCTGAAGGCTCAGTATAAAGAAAAAACTGGGAAGGAGTAC
ATACCTGGTCAGCCCCCATTATCTCAAAGTTCGGATTCAAGCCCAACCAGAAATTCTGAA
CCTGCTGGTTTAGAAACACCAGAAGCGAAAGTACTTTTTGACAAAGTAGCTTCTCAAGGG
GAAGTAGTTCGGAAACTTAAAACTGAAAAAGCCCCTAAGGATCAAGTAGATATAGCTGTT
CAAGAACTCCTTCAGCTAAAGGCACAGTACAAGTCTTTGATAGGAGTAGAGTATAAGCCT
GTGTCGGCCACTGGAGCTGAGGACAAAGATAAGAAGAAGAAAGAAAAAGAAAATAAATCT
GAAAAGCAGAATAAGCCTCAGAAACAAAATGATGGCCAAAGGAAAGACCCTTCTAAAAAC
CAAGGAGGTGGGCTCTCATCAAGTGGAGCAGGAGAAGGGCAGGGGCCTAAGAAACAGACC
AGGTTGGGTCTTGAGGCAAAAAAAGAAGAAAATCTTGCTGATTGGTATTCTCAGGTCATC
ACAAAGTCAGAAATGATTGAATACCATGACATAAGTGGCTGTTATATTCTTCGTCCCTGG
GCCTATGCCATTTGGGAAGCCATCAAGGACTTTTTTGATGCTGAGATCAAGAAACTTGGT
GTTGAAAACTGCTACTTCCCCATGTTTGTGTCTCAAAGTGCATTAGAGAAAGAGAAGACT
CATGTTGCTGACTTTGCCCCAGAGGTTGCTTGGGTTACAAGATCTGGCAAAACCGAGCTG
GCAGAACCAATTGCCATTCGTCCTACTAGTGAAACAGTAATGTATCCTGCATATGCAAAA
TGGGTACAATCACACAGAGACCTGCCCATCAAGCTCAATCAGTGGTGCAATGTGGTGCGT
TGGGAATTCAAGCATCCTCAGCCTTTCCTACGTACTCGTGAATTTCTTTGGCAGGAAGGG
CACAGTGCTTTTGCTACCATGGAAGAGGCAGCGGAAGAGGTCTTGCAGATACTTGACTTA
TATGCTCAGGTATATGAAGAACTCCTGGCAATTCCTGTTGTTAAAGGAAGAAAGACGGAA
AAGGAAAAATTTGCAGGAGGAGACTATACAACTACAATAGAAGCATTTATATCTGCTAGT
GGAAGAGCTATCCAGGGAGGAACATCACATCATTTAGGGCAGAATTTTTCCAAAATGTTT
GAAATCGTTTTTGAAGATCCAAAGATACCAGGAGAGAAGCAATTTGCCTATCAAAACTCC
TGGGGCCTGACAACTCGAACTATTGGTGTTATGACCATGGTTCATGGGGACAACATGGGT
TTAGTATTACCACCCCGTGTAGCATGTGTTCAGGTGGTGATTATTCCTTGTGGCATTACC
AATGCACTTTCTGAAGAAGACAAAGAAGCGCTGATTGCAAAATGCAATGATTATCGAAGG
CGATTACTCAGTGTTAACATCCGCGTTAGAGCTGATTTACGAGATAATTATTCTCCAGGT
TGGAAATTCAATCACTGGGAGCTCAAGGGAGTTCCCATTAGACTTGAAGTTGGGCCACGT
GATATGAAGAGCTGTCAGTTTGTAGCCGTCAGACGAGATACTGGAGAAAAGCTGACAGTT
GCTGAAAATGAGGCAGAGACTAAACTTCAAGCTATTTTGGAAGACATCCAGGTCACCCTT
TTCACAAGGGCTTCTGAAGACCTTAAGACTCATATGGTTGTGGCTAATACAATGGAAGAC
TTTCAGAAGATACTAGATTCTGGAAAGATTGTTCAGATTCCATTCTGTGGGGAAATTGAC
TGTGAGGACTGGATCAAAAAGACCACTGCCAGGGATCAAGATCTTGAACCTGGTGCTCCA
TCCATGGGAGCTAAAAGCCTTTGCATCCCCTTCAAACCACTCTGTGAACTGCAGCCTGGA
GCCAAATGTGTCTGTGGCAAGAACCCTGCCAAGTACTACACCTTATTTGGTCGCAGCTAC
TGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
X54326

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_10_Locus:
1q41-q42

# Metabolic_Enzyme_10_SNPs:
rs5030752; rs2230301; rs35999099; rs34559775; rs5030751; rs1061160; rs5030754; rs36122746; rs1061242; rs1061248; rs6695781; rs2577138; rs1768672; rs2647468; rs1694601; rs2647447; rs2577144; rs2647459; rs2133194; rs2577150; rs1498393; rs2789797; rs2795314; rs2291838; rs2647435; rs2173403; rs2577145; rs1694576; rs2647462; rs2133195; rs2647469; rs1768673; rs2577137; rs1624678; rs2270710; rs2795310; rs2789816; rs2577136; rs2577159; rs7535767; rs1391566; rs10779396; rs7550249; rs1611961; rs7553236; rs2577149; rs2647430; rs6541124; rs10495143; rs3820457; rs3767671; rs6697041; rs6686451; rs1630386; rs2270711; rs10746395; rs1982985; rs7535773; rs12080607; rs6699641; rs6669906; rs1982986; rs2647470; rs2248479; rs2577148; rs2789798; rs4846612; rs2577146; rs2270712; rs1694577; rs2577140; rs2647445; rs2647461; rs2789793; rs10779393; rs6541120; rs1874811; rs2789794; rs2647464; rs7535650; rs2647463; rs6690630; rs3816993; rs2254494; rs2647457; rs2789817; rs2647454; rs2789796; rs11806631; rs2647420; rs2647428; rs2253521; rs2647458; rs2577141; rs1658227; rs2248466; rs2577158; rs6681471; rs2647436; rs2577156; rs2270709; rs7536968; rs2577163; rs10779395; rs11118485; rs3767661; rs4846611; rs2647479; rs11118490; rs7521682; rs6660598; rs2291836; rs2647429; rs3767670; rs1694599; rs2789809; rs6681055; rs1658226; rs2789813; rs12057663; rs10779394; rs10442684; rs12079635; rs2789810; rs11118488; rs10746396; rs2647453; rs10779391; rs7548397; rs2647467; rs3767669; rs2577142; rs10863524; rs10863528; rs11118486; rs10863523; rs7524619; rs7527659; rs1768665; rs10863521; rs7517173; rs4531301; rs2454326; rs12084571; rs3767675; rs1982987; rs7521388; rs2647478; rs7539385; rs6672134; rs17007062; rs10863527; rs4846610; rs6683340; rs7537559; rs7527749; rs12126940; rs12142009; rs2577147; rs2789799; rs4536003; rs949866; rs2789812; rs12022181; rs2789802; rs6703042; rs1768675; rs2647446; rs10863525; rs17007011; rs2248717; rs1612144; rs12032898; rs1557130; rs1846254; rs12032866; rs10442692; rs17006978; rs12123041; rs10863522; rs2647444; rs2647460; rs1694600; rs1768677; rs3767668; rs7537058; rs11118487; rs11118480; rs1768668; rs1622508; rs12073836; rs3767657; rs6674466; rs2647425; rs1566252; rs3820456; rs1768671; rs2789811; rs11118489; rs1768670; rs2647433; rs1768666; rs1498394; rs1874813; rs2486328; rs1874810; rs2577151; rs4379680; rs12069364; rs12726890; rs2248719; rs2577143; rs10863526; rs6692978; rs1982984; rs2245457; rs6681474; rs1694575; rs12048112; rs2577160; rs2789795; rs12140664; rs7545314; rs11811749; rs7531703; rs2577139; rs2647431; rs2789815; rs2647432; rs11118483; rs6690280; rs1874812; rs2577165; rs3767663; rs1768669; rs1874814; rs9988498; rs12117454; rs1846255; rs3767658; rs2647438; rs17007084; rs2647474; rs1768676; rs2647448; rs7534891; rs17006931; rs2577161; rs3816994; rs2027504; rs2030078; rs2030079; rs11118477; rs5030753; rs1063236; rs35325299; rs35055527; rs12144752; rs35578666; rs10987; rs41274786; rs2270713; rs2789804; rs5781162; rs12097519; rs11322745; rs28758924; rs10543617; rs35970586; rs2647424; rs35064558; rs35228542; rs34101093; rs12737399; rs35193743; rs12128043; rs12141517; rs3215088; rs1768667; rs35845125; rs12080935; rs35917562; rs2577164; rs5781163; rs12068478; rs7545874; rs6669531; rs35942761; rs36078678; rs1768674; rs12126592; rs12754826; rs6677609; rs2647423; rs35420771; rs12098052; rs34415535; rs2291837; rs10582505; rs2647434; rs2577157; rs12057468; rs10551734; rs2789806; rs12091960; rs35440326; rs33962064; rs34070653; rs2789800; rs3835619; rs34052861; rs35525846; rs34510927; rs35952109; rs3830400; rs1614719; rs10698600; rs7544184; rs35962858; rs953756; rs12031429; rs6670629; rs12080610; rs28609698; rs3830399; rs33914465; rs2647449; rs34314894; rs12090303; rs10570178; rs36181278; rs35341641; rs12736674; rs7414048; rs2647450; rs10569658; rs2789819; rs35995726; rs35247222; rs7548301; rs12084196; rs12059479; rs34224725; rs35329556; rs2647437; rs3767673; rs2647475; rs35539406; rs11414713; rs11340220; rs11323724; rs10547980; rs11118482; rs3767667; rs12060231; rs35015102; rs35656997; rs2647452; rs12145391; rs35659781; rs11808639; rs12097441; rs12141971; rs10157133; rs7525311; rs10612871; rs12071984; rs35469644; rs34084629; rs2789808; rs34084372; rs12238988; rs12059527; rs12754990; rs2647427; rs34218503; rs9786983; rs10645019; rs12747650; rs2789807; rs11284910; rs35194885; rs34320023; rs12062082; rs11325774; rs10697205; rs10638364; rs2789805; rs10697206; rs35018508; rs10465680; rs35938749; rs10554810; rs5781161; rs12090804; rs11118478; rs6680671; rs34316201; rs35787330; rs2795315; rs41304103; rs10656420; rs34626963; rs1614384; rs12071410; rs12059273; rs11291617; rs35145633; rs2647451; rs2647456; rs34170326; rs12040930; rs2647422; rs36089275; rs34459588; rs35449773; rs35391458; rs12045445; rs7539406; rs1542840; rs34090474; rs1614585; rs41274788; rs2011624; rs12095669; rs34544630; rs6702241; rs2647421; rs28612895; rs7524382; rs10442691; rs12081205; rs34917248; rs2133196; rs10551735; rs34309222; rs35204038; rs3835618; rs6667964; rs35446521; rs35241194; rs41304101; rs17007032; rs11278281; rs2647426; rs10595099; rs11382775; rs12049352; rs35440314; rs10570179; rs12058150; rs3055587; rs34026037; rs34537346; rs34343274; rs12076227; rs12046562; rs34094913; rs3835617; rs34000580; rs34321649; rs35060859; rs35108914; rs2647455; rs1909199; rs3916109; rs36065087; rs28570471; rs12072662; rs11286771; rs11118481; rs2789803; rs2577162; rs11317813; rs5781164; rs35421250; rs10157645; rs5781160; rs35984976; rs11355174; rs35879695; rs35533895; rs10611128; rs11590370; rs10779390; rs11118476; rs12734813; rs2789784; rs4846608; rs6663868; rs6663947; rs7516830; rs7549576

# Metabolic_Enzyme_10_General_References:
1988429; 3290852; 1756734; 1556743; 11123902

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5840

# Metabolic_Enzyme_11_Name:
Ubiquitin-conjugating enzyme E2-25 kDa

# Metabolic_Enzyme_11_Synonyms:
Ubiquitin- protein ligase; Ubiquitin carrier protein; E2(25K; Huntingtin- interacting protein 2; HIP-2

# Metabolic_Enzyme_11_Gene_Name:
HIP2

# Metabolic_Enzyme_11_Protein_Sequence:
>Ubiquitinconjugating enzyme E225 kDa
MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEI
KIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAA
EPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVI
VALSSKSWDVETATELLLSN

# Metabolic_Enzyme_11_Number_of_Residues:
200

# Metabolic_Enzyme_11_Molecular_Weight:
22407

# Metabolic_Enzyme_11_Theoretical_pI:
5.10

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Not Available

# Metabolic_Enzyme_11_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53

# Metabolic_Enzyme_11_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_11_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00627:UBA;
PF00179:UQ_con

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_11_GenBank_ID_Protein:
1381164

# Metabolic_Enzyme_11_SwissProt_ID:
UBC1_HUMAN (P61086)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
HIP2

# Metabolic_Enzyme_11_Geneatlas_id:
HIP2

# Metabolic_Enzyme_11_hgnc_id:
HGNC:4914

# Metabolic_Enzyme_11_PDB_ID:
1YLA

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_11_Gene_Sequence:
>603 bp
ATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAG
GAGACGAGCAAAAATCAAATTAAAGTAGATCTTGTAGATGAGAATTTTACAGAATTAAGA
GGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGATACCAACTAGAGATA
AAAATACCAGAAACATACCCATTTAATCCCCCTAAGGTCCGGTTTATCACTAAAATATGG
CATCCTAATATTAGTTCCGTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAATGG
GCAGCTGCAATGACTCTCCGCACGGTATTATTGTCATTGCAAGCACTATTGGCAGCTGCA
GAGCCAGATGATCCACAGGATGCTGTAGTAGCAAATCAGTACAAACAAAATCCCGAAATG
TTCAAACAGACAGCTCGACTTTGGGCACATGTGTATGCTGGAGCACCAGTTTCTAGTCCA
GAATACACCAAAAAAATAGAAAACCTATGTGCTATGGGCTTTGATAGGAATGCAGTAATA
GTGGCCTTGTCTTCAAAATCATGGGATGTAGAGACTGCAACAGAATTGCTTCTGAGTAAC
TGA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
U58522

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_11_Locus:
4p14

# Metabolic_Enzyme_11_SNPs:
rs438344; rs725856; rs463918; rs417393; rs459274; rs2054718; rs302948; rs7687557; rs467032; rs302931; rs4975036; rs877075; rs7697939; rs305121; rs305826; rs215399; rs6830937; rs302946; rs302949; rs2381428; rs305825; rs725857; rs302935; rs456157; rs305827; rs302938; rs305125; rs10440307; rs302952; rs12645606; rs6828986; rs383020; rs13129403; rs302937; rs3806739; rs12644528; rs6531738; rs6810434; rs7684747; rs652162; rs11945490; rs305124; rs11939222; rs9996105; rs12648825; rs431419; rs7663847; rs10517528; rs1384531; rs12641379; rs159987; rs10856850; rs11933569; rs7678527; rs11942087; rs9683743; rs302932; rs12647535; rs188566; rs418876; rs4512005; rs2279850; rs7693996; rs465233; rs12646744; rs10004937; rs13121644; rs12506764; rs10015357; rs35401248; rs12642132; rs13108390; rs302941; rs302947; rs167360; rs1055582; rs17510894; rs7665965; rs4974947; rs411556; rs13147205; rs12507502; rs7690684; rs17585617; rs4403062; rs7441133; rs6531741; rs13435632; rs7656037; rs7683797; rs724256; rs4974948; rs461962; rs11947610; rs302950; rs602049; rs9306975; rs10029519; rs13150753; rs10022877; rs440105; rs7697286; rs7656723; rs7661070; rs4362831; rs12505675; rs302936; rs6814847; rs12645756; rs614180; rs10005267; rs13122400; rs4377601; rs7441135; rs12649966; rs12648483; rs302945; rs2170613; rs13139884; rs305123; rs10014622; rs12648906; rs6818053; rs302940; rs4314294; rs6848230; rs12513088; rs3912392; rs7658679; rs3912391; rs9996828; rs17439268; rs34945144; rs3839130; rs1064268; rs458618; rs34388979; rs34643475; rs10022177; rs28664181; rs35905641; rs2381427; rs415625; rs11406192; rs35852990; rs12641284; rs34711359; rs28650183; rs11315878; rs191002; rs34394500; rs28394846; rs17439205; rs7695000; rs35605027; rs36032554; rs10007588; rs10683010; rs35095660; rs34373308; rs13103577; rs28567992; rs35461119; rs13140152; rs34508184; rs28752210; rs6848232; rs6531740; rs28727931; rs10032541; rs28379845; rs28475675; rs34603997; rs34513146; rs28475266; rs305122; rs10033569; rs34406402; rs13123105; rs10659004; rs28651273; rs28626946; rs11393049; rs9799379; rs28495663; rs35360114; rs12643005; rs28519425; rs11727635; rs35230099; rs28379059; rs3839129; rs446539; rs35941407; rs36211815; rs28459348; rs11407762; rs28670201; rs16995470; rs28666528; rs12647701; rs7437985; rs462069; rs188565; rs463322; rs28668414; rs388277; rs28469340; rs4543121; rs4975037; rs34121884; rs28449607; rs302934; rs13137353; rs35785999; rs35484323; rs28610924; rs33949384; rs35850563; rs35596173; rs7377134; rs10650873; rs403338; rs13103375; rs35490777; rs9993641; rs160096; rs28702416; rs11726696; rs9998102; rs34796394; rs35768449; rs10027513; rs10006221; rs36004717; rs457198; rs13113031; rs7654219; rs35064302; rs36215155; rs35488035; rs34812049; rs458114; rs3070777; rs11947966; rs401797; rs10674974; rs13113029; rs34238835; rs34434032; rs10007152; rs10716637; rs36232683; rs401196; rs35121528; rs34700981; rs11452198; rs35251652; rs28637149; rs28645678; rs35599030; rs404985; rs33946386; rs12643916; rs28567929; rs28612080; rs7437980; rs12646741; rs35355790; rs34112267; rs34201270; rs11295454; rs33925862; rs7679042; rs28465426; rs465113; rs35733561; rs442644; rs11323808; rs6825216; rs35957337; rs10440308; rs167328; rs33911981; rs28588288; rs28602495; rs11389468; rs33973834; rs302933; rs35468992; rs10538309; rs10001359; rs28582996; rs41282377; rs36046193; rs462108; rs35470056; rs9995971; rs28695490; rs11276965; rs28366560; rs34608829; rs35696651; rs3841980; rs28628754; rs160088; rs7657535; rs33995934; rs7440233; rs34679528; rs35547843; rs7688345; rs36214079; rs33977990; rs28438631; rs36098911; rs6531739; rs35004843; rs33914257; rs35647476; rs28749267; rs2381431; rs455159; rs466169; rs28629917; rs34218534; rs34727929; rs28370449; rs461918; rs11364737; rs34509777; rs34820330; rs159986; rs3932978; rs13134745; rs13123425; rs11936326; rs35173955; rs28435721; rs10009932; rs35183095; rs35646853; rs34417192; rs167327; rs28620307; rs28719817; rs11407158; rs28742000; rs35367181; rs2381429; rs10015234; rs413452; rs5857700; rs10639345; rs34133576; rs35972302; rs149477; rs33916064; rs7694944; rs35127944; rs4502689; rs28600929; rs28407484; rs6857873; rs34258469; rs35532814; rs35022888; rs35287077; rs419332; rs7668685; rs191001; rs28526586; rs10541441; rs28529766; rs13118375; rs34597587; rs10017303; rs35240266; rs35637004; rs11931904; rs7685348; rs12641923; rs33928368; rs463979; rs34859728; rs34462851; rs35210500; rs12643006; rs10699520; rs33918227; rs2627640; rs35005914; rs3069986; rs13142225; rs28575253; rs28361492; rs34401637; rs33959570; rs172552; rs9884353; rs35691398; rs34937270; rs5857698; rs28665570; rs614244; rs28849716; rs10012529; rs35370194; rs10540741; rs7674430; rs7685711; rs36120820; rs34132162; rs36213849; rs28680293; rs11417002; rs35215180; rs33944466; rs2381430; rs302951; rs650776; rs4975038; rs12510135; rs35586404; rs34069872; rs34032249; rs28469239; rs7685905; rs28730991; rs462088; rs458130; rs35635575; rs35078805; rs28479189; rs585756; rs28587078; rs28407810; rs34362070; rs4974946; rs13117685; rs6531737; rs35286645; rs4008351; rs7657126; rs302943; rs9999915; rs302942; rs1057047; rs35805800; rs35966248; rs28450192; rs7657502; rs35005579; rs1057048; rs4008350; rs10050182; rs10517530; rs1531897; rs192779; rs2128106; rs305135; rs305136; rs4263408; rs4388095; rs7670291; rs7680474; rs7681867

# Metabolic_Enzyme_11_General_References:
8702625; 10634809; 10675012; 12665801

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5351

# Metabolic_Enzyme_12_Name:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

# Metabolic_Enzyme_12_Synonyms:
E- NPP 1; Phosphodiesterase I/nucleotide pyrophosphatase 1; Plasma-cell membrane glycoprotein PC-1[Includes: Alkaline phosphodiesterase I; NPPase]

# Metabolic_Enzyme_12_Gene_Name:
ENPP1

# Metabolic_Enzyme_12_Protein_Sequence:
>Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPL
EKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNC
RCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINY
SSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKK
CGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEW
YKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLP
KDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLIL
ISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSC
REPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNV
FSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVY
TPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYG
RPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPL
SPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTL
LRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKD
TSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSF
YQQRKEPVSDILKLKTHLPTFSQED

# Metabolic_Enzyme_12_Number_of_Residues:
925

# Metabolic_Enzyme_12_Molecular_Weight:
104925

# Metabolic_Enzyme_12_Theoretical_pI:
7.14

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  nuclease activity
Function:  endonuclease activity
Function:  binding
Function:  nucleic acid binding
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Not Available

# Metabolic_Enzyme_12_Specific_Function:
Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity

# Metabolic_Enzyme_12_Pathway:
map00230  Purine metabolism;
 map00500  Starch and sucrose metabolism;
 map00740  Riboflavin metabolism;
 map00760  Nicotinate and nicotinamide metabolism;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_12_Reaction:
A dinucleotide + H2O = 2 mononucleotides

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF01663:Phosphodiest;
PF01033:Somatomedin_B

# Metabolic_Enzyme_12_Signals:
None

# Metabolic_Enzyme_12_Transmembrane_Regions:
77-97

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 3.1.4.1;EC 3.6.1.9

# Metabolic_Enzyme_12_GenBank_ID_Protein:
189650

# Metabolic_Enzyme_12_SwissProt_ID:
ENPP1_HUMAN (P22413)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
ENPP1

# Metabolic_Enzyme_12_Geneatlas_id:
ENPP1

# Metabolic_Enzyme_12_hgnc_id:
HGNC:3356

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Membrane; single-pass type II membrane protein. Note=Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts. In bile duct cells and cancer cells, located to the apical cytoplasmic side

# Metabolic_Enzyme_12_Gene_Sequence:
>2622 bp
ATGGACGTGGGGGAGGAGCCGCTGGAGAAGGCGGCGCGCGCCCGCACTGCCAAGGACCCC
AACACCTATAAAGTACTCTCGCTGGTATTGTCAGTATGTGTGTTAACAACAATACTTGGT
TGTATATTTGGGTTGAAACCAAGCTGTGCCAAAGAAGTTAAAAGTTGCAAAGGTCGCTGT
TTCGAGAGAACATTTGGGAACTGTCGCTGTGATGCTGCCTGTGTTGAGCTTGGAAACTGC
TGTTTAGATTACCAGGAGACGTGCATAGAACCAGAACATATATGGACTTGCAACAAATTC
AGGTGTGGTGAGAAAAGGTTGACCAGAAGCCTCTGTGCCTGTTCAGATGACTGCAAGGAC
AAGGGCGACTGCTGCATCAACTACAGTTCTGTGTGTCAAGGTGAGAAAAGTTGGGTAGAA
GAACCATGTGAGAGCATTAATGAGCCACAGTGCCCAGCAGGGTTTGAAACGCCTCCTACC
CTCTTATTTTCTTTGGATGGATTCAGGGCAGAATATTTACACACTTGGGGTGGACTTCTT
CCTGTTATTAGCAAACTAAAAAAATGTGGAACATATACTAAAAACATGAGACCGGTATAT
CCAACAAAAACTTTCCCCAATCACTACAGCATTGTCACCGGATTGTATCCAGAATCTCAT
GGCATAATCGACAATAAAATGTATGATCCCAAAATGAATGCTTCCTTTTCACTTAAAAGT
AAAGAGAAATTTAATCCTGAGTGGTACAAAGGAGAACCAATTTGGGTCACAGCTAAGTAT
CAAGGCCTCAAGTCTGGCACATTTTTCTGGCCAGGATCAGATGTGGAAATTAACGGAATT
TTCCCAGACATCTATAAAATGTATAATGGTTCAGTACCATTTGAAGAAAGGATTTTAGCT
GTTCTTCAGTGGCTACAGCTTCCTAAAGATGAAAGACCACACTTTTACACTCTGTATTTA
GAAGAACCAGATTCTTCAGGTCATTCATATGGACCAGTCAGCAGTGAAGTCATCAAAGCC
TTGCAGAGGGTTGATGGTATGGTTGGTATGCTGATGGATGGTCTGAAAGAGCTGAACTTG
CACAGATGCCTGAACCTCATCCTTATTTCAGATCATGGCATGGAACAAGGCAGTTGTAAG
AAATACATATATCTGAATAAATATTTGGGGGATGTTAAAAATATTAAAGTTATCTATGGA
CCTGCAGCTCGATTGAGACCCTCTGATGTCCCAGATAAATACTATTCATTTAACTATGAA
GGCATTGCCCGAAATCTTTCTTGCCGGGAACCAAACCAGCACTTCAAACCTTACCTGAAA
CATTTCTTACCTAAGCGTTTGCACTTTGCTAAGAGTGATAGAATTGAGCCCTTGACATTC
TATTTGGACCCTCAGTGGCAACTTGCATTGAATCCCTCAGAAAGGAAATATTGTGGAAGT
GGATTTCATGGCTCTGACAATGTATTTTCAAATATGCAAGCCCTCTTTGTTGGCTATGGA
CCTGGATTCAAGCATGGCATTGAGGCTGACACCTTTGAAAACATTGAAGTCTATAACTTA
ATGTGTGATTTACTGAATTTGACACCGGCTCCTAATAACGGAACTCATGGAAGTCTTAAC
CACCTTCTAAAGAATCCTGTTTATACGCCAAAGCATCCCAAAGAAGTGCACCCCCTGGTA
CAGTGCCCCTTCACAAGAAACCCCAGAGATAACCTTGGCTGCTCATGTAACCCTTCGATT
TTGCCGATTGAGGATTTTCAAACACAGTTCAATCTGACTGTGGCAGAAGAGAAGATTATT
AAGCATGAAACTTTACCCTATGGAAGACCTAGAGTTCTCCAGAAGGAAAACACCATCTGT
CTTCTTTCCCAGCACCAGTTTATGAGTGGATACAGCCAAGACATCTTAATGCCCCTTTGG
ACATCCTATACCGTGGACAGAAATGACAGTTTCTCTACGGAAGACTTCTCCAACTGTCTG
TACCAGGACTTTAGAATTCCTCTTAGTCCTGTCCATAAATGTTCATTTTATAAAAATAAC
ACCAAAGTGAGTTACGGGTTCCTCTCCCCACCACAACTAAATAAAAATTCAAGTGGAATA
TATTCTGAAGCTTTGCTTACTACAAATATAGTGCCAATGTACCAGAGTTTTCAAGTTATA
TGGCGCTACTTTCATGACACCCTACTGCGAAAGTATGCTGAAGAAAGAAATGGTGTCAAT
GTCGTCAGTGGTCCTGTGTTTGACTTTGATTATGATGGACGTTGTGATTCCTTAGAGAAT
CTGAGGCAAAAAAGAAGAGTCATCCGTAACCAAGAAATTTTGATTCCAACTCACTTCTTT
ATTGTGCTAACAAGCTGTAAAGATACATCTCAGACGCCTTTGCACTGTGAAAACCTAGAC
ACCTTAGCTTTCATTTTGCCTCACAGGACTGATAACAGCGAGAGCTGTGTGCATGGGAAG
CATGACTCCTCATGGGTTGAAGAATTGTTAATGTTACACAGAGCACGGATCACAGATGTT
GAGCACATCACTGGACTCAGCTTCTATCAACAAAGAAAAGAGCCAGTTTCAGACATTTTA
AAGTTGAAAACACATTTGCCAACCTTTAGCCAAGAAGACTGA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
M57736

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_12_Locus:
6q22-q23

# Metabolic_Enzyme_12_SNPs:
Not Available

# Metabolic_Enzyme_12_General_References:
2211644; 1315502; 14574404; 10480624; 8001561; 7737162; 9344668; 10453738

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5229

# Metabolic_Enzyme_13_Name:
5'-nucleotidase precursor

# Metabolic_Enzyme_13_Synonyms:
Ecto-5'-nucleotidase; 5'-NT; CD73 antigen

# Metabolic_Enzyme_13_Gene_Name:
NT5E

# Metabolic_Enzyme_13_Protein_Sequence:
>5'nucleotidase precursor
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ

# Metabolic_Enzyme_13_Number_of_Residues:
574

# Metabolic_Enzyme_13_Molecular_Weight:
63368

# Metabolic_Enzyme_13_Theoretical_pI:
7.04

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  hydrolase activity, acting on ester bonds
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_13_Specific_Function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides

# Metabolic_Enzyme_13_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_13_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF02872:5_nucleotid_C;
PF00149:Metallophos

# Metabolic_Enzyme_13_Signals:
1-26

# Metabolic_Enzyme_13_Transmembrane_Regions:
556-573

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_13_GenBank_ID_Protein:
23897

# Metabolic_Enzyme_13_SwissProt_ID:
5NTD_HUMAN (P21589)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
NT5E

# Metabolic_Enzyme_13_Geneatlas_id:
NT5E

# Metabolic_Enzyme_13_hgnc_id:
HGNC:8021

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Metabolic_Enzyme_13_Gene_Sequence:
>1725 bp
ATGTGTCCCCGAGCCGCGCGGGCGCCCGCGACGCTACTCCTCGCCCTGGGCGCGGTGCTG
TGGCCTGCGGCTGGCGCCTGGGAGCTTACGATTTTGCACACCAACGACGTGCACAGCCGG
CTGGAGCAGACCAGCGAGGACTCCAGCAAGTGCGTCAACGCCAGCCGCTGCATGGGTGGC
GTGGCTCGGCTCTTCACCAAGGTTCAGCAGATCCGCCGCGCCGAACCCAACGTGCTGCTG
CTGGACGCCGGCGACCAGTACCAGGGCACTATCTGGTTCACCGTGTACAAGGGCGCCGAG
GTGGCGCACTTCATGAACGCCCTGCGCTACGATGCCATGGCACTGGGAAATCATGAATTT
GATAATGGTGTGGAAGGACTGATCGAGCCACTCCTCAAAGAGGCCAAATTTCCAATTCTG
AGTGCAAACATTAAAGCAAAGGGGCCACTAGCATCTCAAATATCAGGACTTTATTTGCCA
TATAAAGTTCTTCCTGTTGGTGATGAAGTTGTGGGAATCGTTGGATACACTTCCAAAGAA
ACCCCTTTTCTCTCAAATCCAGGGACAAATTTAGTGTTTGAAGATGAAATCACTGCATTA
CAACCTGAAGTAGATAAGTTAAAAACTCTAAATGTGAACAAAATTATTGCACTGGGACAT
TCGGGTTTTGAAATGGATAAACTCATCGCTCAGAAAGTGAGGGGTGTGGACGTCGTGGTG
GGAGGACACTCCAACACATTTCTTTACACAGGCAATCCACCTTCCAAAGAGGTGCCTGCT
GGGAAGTACCCATTCATAGTCACTTCTGATGATGGGCGGAAGGTTCCTGTAGTCCAGGCC
TATGCTTTTGGCAAATACCTAGGCTATCTGAAGATCGAGTTTGATGAAAGAGGAAACGTC
ATCTCTTCCCATGGAAATCCCATTCTTCTAAACAGCAGCATTCCTGAAGATCCAAGCATA
AAAGCAGACATTAACAAATGGAGGATAAAATTGGATAATTATTCTACCCAGGAATTAGGG
AAAACAATTGTCTATCTGGATGGCTCCTCTCAATCATGCCGCTTTAGAGAATGCAACATG
GGCAACCTGATTTGTGATGCAATGATTAACAACAACCTGAGACACACGGATGAAATGTTC
TGGAACCACGTATCCATGTGCATTTTAAATGGAGGTGGTATCCGGTCGCCCATTGATGAA
CGCAACAATGGCACAATTACCTGGGAGAACCTGGCTGCTGTATTGCCCTTTGGAGGCACA
TTTGACCTAGTCCAGTTAAAAGGTTCCACCCTGAAGAAGGCCTTTGAGCATAGCGTGCAC
CGCTACGGCCAGTCCACTGGAGAGTTCCTGCAGGTGGGCGGAATCCATGTGGTGTATGAT
CTTTCCCGAAAACCTGGAGACAGAGTAGTCAAATTAGATGTTCTTTGCACCAAGTGTCGA
GTGCCCAGTTATGACCCTCTCAAAATGGACGAGGTATATAAGGTGATCCTCCCAAACTTC
CTGGCCAATGGTGGAGATGGGTTCCAGATGATAAAAGATGAATTATTAAGACATGACTCT
GGTGACCAAGATATCAACGTGGTTTCTACATATATCTCCAAAATGAAAGTAATTTATCCA
GCAGTTGAAGGTCGGATCAAGTTTTCCACAGGAAGTCACTGCCATGGAAGCTTTTCTTTA
ATATTTCTTTCACTTTGGGCAGTGATCTTTGTTTTATACCAATAG

# Metabolic_Enzyme_13_GenBank_ID_Gene:
X55740

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_13_Locus:
6q14-q21

# Metabolic_Enzyme_13_SNPs:
Not Available

# Metabolic_Enzyme_13_General_References:
2129526; 8566797; 2173922; 9651114

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5841

# Metabolic_Enzyme_14_Name:
Adenylate kinase isoenzyme 2, mitochondrial

# Metabolic_Enzyme_14_Synonyms:
ATP-AMP transphosphorylase

# Metabolic_Enzyme_14_Gene_Name:
AK2

# Metabolic_Enzyme_14_Protein_Sequence:
>Adenylate kinase isoenzyme 2, mitochondrial
MAPSVPAAEPEYPKGIRAVLLGPPGAGKGTQAPRLAENFCVCHLATGDMLRAMVASGSEL
GKKLKATMDAGKLVSDEMVVELIEKNLETPLCKNGFLLDGFPRTVRQAEMLDDLMEKRKE
KLDSVIEFSIPDSLLIRRITGRLIHPKSGRSYHEEFNPPKEPMKDDITGEPLIRRSDDNE
KALKIRLQAYHTQTTPLIEYYRKRGIHSAIDASQTPDVVFASILAAFSKATCKDLVMFI

# Metabolic_Enzyme_14_Number_of_Residues:
239

# Metabolic_Enzyme_14_Molecular_Weight:
26478

# Metabolic_Enzyme_14_Theoretical_pI:
7.97

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  adenylate kinase activity
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleotide kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
This small ubiquitous enzyme is essential for maintenance and cell growth

# Metabolic_Enzyme_14_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_14_Reaction:
ATP + AMP = 2 ADP

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00406:ADK;
PF05191:ADK_lid

# Metabolic_Enzyme_14_Signals:
None

# Metabolic_Enzyme_14_Transmembrane_Regions:
None

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 2.7.4.3

# Metabolic_Enzyme_14_GenBank_ID_Protein:
1209687

# Metabolic_Enzyme_14_SwissProt_ID:
KAD2_HUMAN (P54819)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
AK2

# Metabolic_Enzyme_14_Geneatlas_id:
AK2

# Metabolic_Enzyme_14_hgnc_id:
HGNC:362

# Metabolic_Enzyme_14_PDB_ID:
2AK2

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Mitochondrion; mitochondrial intermembrane space

# Metabolic_Enzyme_14_Gene_Sequence:
>720 bp
ATGGCTCCCAGCGTGCCAGCGGCAGAACCCGAGTATCCTAAAGGCATCCGGGCCGTGCTG
CTGGGGCCTCCCGGGGCCGGTAAAGGGACCCAGGCACCCAGATTGGCTGAAAACTTCTGT
GTCTGCCATTTAGCTACTGGGGACATGCTGAGGGCCATGGTGGCTTCTGGCTCAGAGCTA
GGAAAAAAGCTGAAGGCAACTATGGATGCTGGGAAACTGGTGAGTGATGAAATGGTAGTG
GAGCTCATTGAGAAGAATTTGGAGACCCCCTTGTGCAAAAATGGTTTTCTTCTGGATGGC
TTCCCTCGGACTGTGAGGCAGGCAGAAATGCTCGATGACCTCATGGAGAAGAGGAAAGAG
AAGCTTGATTCTGTGATTGAATTCAGCATCCCAGACTCTCTGCTGATCCGAAGAATCACA
GGAAGGCTGATTCACCCCAAGAGTGGCCGTTCCTACCACGAGGAGTTCAACCCTCCAAAA
GAGCCCATGAAAGATGACATCACCGGGGAACCCTTGATCCGTCGATCAGATGATAATGAA
AAGGCCTTGAAAATCCGCCTGCAAGCCTACCACACTCAAACCACCCCACTCATAGAGTAC
TACAGGAAACGGGGGATCCACTCCGCCATCGATGCATCCCAGACCCCCGATGTCGTGTTC
GCAAGCATCCTAGCAGCCTTCTCCAAAGCCACATGTAAAGACTTGGTTATGTTTATCTAA


# Metabolic_Enzyme_14_GenBank_ID_Gene:
U39945

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_14_Locus:
1p34

# Metabolic_Enzyme_14_SNPs:
rs12116440; rs998664; rs6884; rs2075986; rs2268691; rs3766810; rs2268692; rs10914643; rs2268693; rs10798924; rs13376642; rs10914647; rs1012884; rs10914649; rs11799675; rs11591185; rs10914645; rs7521588; rs10753271; rs10914642; rs3766811; rs10914646; rs11799809; rs12409924; rs12082671; rs2038023; rs10914644; rs11576688; rs10914648; rs7523652; rs16835243; rs10399832; rs9970553; rs12095142; rs1534892; rs1534893; rs1804813; rs35731438; rs41301072; rs1003961; rs11015; rs4045165; rs34560906; rs4045171; rs1058771; rs34574865; rs11509; rs4045169; rs41265879; rs3958633; rs12568596; rs34253212; rs4045170; rs2335940; rs41265877; rs12137139; rs35960731; rs12041090; rs35607181; rs35955745; rs34516962; rs10218504; rs34219707; rs34411166; rs10399747; rs34489539; rs34651021; rs35543633; rs34048886; rs34760662; rs4951776; rs35310810; rs35291940; rs28546883; rs2284806; rs35111200; rs34622889; rs12117130; rs12116791; rs2300663; rs12096662; rs12096720; rs34804406; rs12117444; rs35815280; rs35303597; rs35256792; rs36095882; rs35769076; rs10753272; rs10914641; rs10914650; rs11810032; rs16835240; rs34118272; rs35604827; rs4561002; rs6660919; rs9633313

# Metabolic_Enzyme_14_General_References:
8843353; 9504408; 9434148

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5842

# Metabolic_Enzyme_15_Name:
Long-chain-fatty-acid--CoA ligase 4

# Metabolic_Enzyme_15_Synonyms:
Long-chain acyl-CoA synthetase 4; LACS 4

# Metabolic_Enzyme_15_Gene_Name:
ACSL4

# Metabolic_Enzyme_15_Protein_Sequence:
>LongchainfattyacidCoA ligase 4
MKLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYR
SVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLIL
GNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTL
YATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPE
GFEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMT
GQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSK
GDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLC
NLLLFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEV
TDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAED
YSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDN
ICAFAKSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANAM
KLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMYGGK

# Metabolic_Enzyme_15_Number_of_Residues:
711

# Metabolic_Enzyme_15_Molecular_Weight:
79189

# Metabolic_Enzyme_15_Theoretical_pI:
8.51

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_15_Specific_Function:
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates

# Metabolic_Enzyme_15_Pathway:
map00071  Fatty acid metabolism

# Metabolic_Enzyme_15_Reaction:
ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_15_Signals:
1-23

# Metabolic_Enzyme_15_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 6.2.1.3

# Metabolic_Enzyme_15_GenBank_ID_Protein:
3158351

# Metabolic_Enzyme_15_SwissProt_ID:
ACSL4_HUMAN (O60488)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
ACSL4

# Metabolic_Enzyme_15_Geneatlas_id:
ACSL4

# Metabolic_Enzyme_15_hgnc_id:
HGNC:3571

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type III membrane protein. Peroxisome; peroxisomal membrane; single-pass type III membrane protein (By similarity). Microsome; microsomal membrane; single-pass type III membrane protein (By similarity)

# Metabolic_Enzyme_15_Gene_Sequence:
>2013 bp
ATGGCAAAGAGAATAAAAGCTAAGCCCACTTCAGACAAACCTGGAAGTCCATATCGCTCT
GTCACACACTTCGACTCACTAGCTGTAATAGACATCCCTGGAGCAGATACTCTGGATAAA
TTATTTGACCATGCTGTATCCAAGTTTGGGAAGAAGGACAGCCTTGGGACCAGGGAAATC
CTAAGTGAAGAAAATGAAATGCAGCCAAATGGAAAAGTTTTTAAGAAGTTAATTCTTGGG
AATTATAAATGGATGAACTATCTTGAAGTGAATCGCAGAGTGAATAACTTTGGTAGTGGA
CTCACTGCACTGGGACTAAAACCAAAGAACACCATTGCCATCTTCTGTGAGACCAGGGCC
GAATGGATGATTGCAGCACAGACCTGCTTTAAGTACAACTTTCCTCTTGTGACTTTATAT
GCCACACTTGGCAAAGAAGCAGTAGTTCATGGGCTAAATGAATCTGAGGCTTCCTATCTG
ATTACCAGTGTTGAACTTCTGGAAAGTAAACTTAAGACTGCATTGTTAGATATCAGTTGT
GTTAAACATATCATTTATGTGGACAATAAGGCTATCAATAAAGCAGAGTACCCTGAAGGA
TTTGAGATTCACAGCATGCAATCAGTAGAAGAGTTGGGATCTAACCCAGAAAACTTGGGC
ATTCCTCCAAGTAGACCAACGCCTTCAGACATGGCCATTGTTATGTATACTAGTGGTTCT
ACTGGCCGACCTAAGGGAGTGATGATGCATCATAGCAATTTGATAGCTGGAATGACAGGC
CAGTGTGAAAGAATACCTGGACTGGGACCGAAGGACACATATATTGGCTACTTGCCTTTG
GCTCATGTGCTAGAACTGACAGCAGAGATATCTTGCTTTACCTATGGCTGCAGGATTGGA
TATTCTTCTCCGCTTACACTCTCTGACCAGTCCAGCAAAATTAAAAAAGGAAGCAAAGGA
GACTGTACTGTACTGAAGCCCACACTTATGGCTGCTGTTCCGGAAATCATGGATAGAATT
TATAAGAATGTTATGAGCAAAGTCCAAGAGATGAATTATATTCAGAAAACTCTGTTCAAG
ATAGGGTATGATTACAAATTGGAACAGATCAAAAAGGGATATGATGCACCTCTTTGCAAT
CTGTTACTGTTTAAAAAGGTCAAGGCCCTGCTGGGAGGGAATGTCCGCATGATGCTGTCT
GGAGGGGCCCCGCTATCTCCTCAGACACACCGATTCATGAATGTCTGCTTCTGCTGCCCA
ATTGGCCAGGGTTATGGACTGACAGAATCATGTGGTGCTGGGACAGTTACTGAAGTAACT
GACTATACTACTGGCAGAGTTGGAGCACCTCTTATTTGCTGTGAAATTAAGCTAAAAGAC
TGGCAAGAAGGCGGTTATACAATTAATGACAAGCCAAACCCCAGAGGTGAAATCGTAATT
GGTGGACAGAACATCTCCATGGGATATTTTAAAAATGAAGAGAAAACAGCAGAAGATTAT
TCTGTGGATGAAAATGGACAAAGGTGGTTTTGCACTGGTGATATTGGAGAATTCCATCCC
GATGGATGTTTACAGATTATAGATCGTAAGAAAGATCTAGTGAAGTTACAAGCAGGAGAG
TATGTATCTCTTGGGAAAGTAGAAGCTGCACTGAAGAATTGTCCACTTATTGACAACATC
TGTGCTTTTGCCAAAAGTGATCAGTCCTATGTGATCAGTTTTGTGGTTCCTAACCAGAAA
AGGTTGACACTTTTGGCACAACAGAAAGGGGTAGAAGGAACTTGGGTTGATATCTGCAAT
AATCCTGCTATGGAAGCTGAAATACTGAAAGAAATTCGAGAAGCTGCAAATGCCATGAAA
TTGGAGCGATTTGAAATTCCAATCAAGGTTCGATTAAGCCCAGAGCCATGGACCCCTGAA
ACTGGTTTGGTAACTGATGCTTTCAAACTGAAAAGGAAGGAGCTGAGGAACCATTACCTC
AAAGACATTGAACGAATGTATGGGGGCAAATAA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
AF030555

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_15_Locus:
Xq22.3-q23

# Metabolic_Enzyme_15_SNPs:
rs2147518; rs5943421; rs4893538; rs5943427; rs1324805; rs1802109; rs5985760; rs5942832; rs4893536; rs5943418; rs6568270; rs5985761; rs5943414; rs5943423; rs10127341; rs5943420; rs7056314; rs5943425; rs4520340; rs5943416; rs5943426; rs5985400; rs10126612; rs5985404; rs5943424; rs12856122; rs5943419; rs5985403; rs5942830; rs839406; rs5943413; rs5985752; rs5985753; rs839407; rs11795780; rs5985399; rs7886473; rs5985398; rs7887981; rs11798398; rs866799; rs7888546; rs839408; rs5985751; rs839409; rs839402; rs5943408; rs5985754; rs839405; rs5985750; rs12156713; rs5943428; rs34221826; rs17853346; rs6655223; rs12835747; rs34702145; rs34583814; rs6643466; rs34685485; rs35513711; rs5985406; rs5943415; rs34231190; rs34571782; rs10574554; rs35928030; rs2038802; rs35191659; rs34694513; rs12847335; rs4893537; rs5985405; rs12010735; rs35077907; rs6643469; rs1063544; rs35736807; rs6643468; rs34379159; rs6643470; rs28663608; rs7057123; rs35038796; rs34773820; rs9699192; rs12383143; rs5943422; rs1555729; rs34867628; rs11552088; rs34826689; rs6643467; rs12844283; rs6643472; rs5985402; rs11322335; rs6643471; rs34058667; rs35186119; rs35218038; rs12389738; rs35144454; rs35175681; rs12011532; rs12857092; rs12856802; rs12857086; rs5985755; rs5943411; rs12856751; rs35072231; rs28624880; rs4442305; rs839403; rs41307405; rs839404; rs1103679; rs12834982; rs36115643; rs3831071; rs5943412; rs3788761; rs12687434; rs3886256; rs5985756; rs7884086; rs28567470; rs5985759; rs6655222; rs12688079; rs34597417; rs12846737; rs12835879; rs12687117; rs5985757; rs34910449; rs34210031; rs35262228; rs12689515; rs2281822; rs5942833; rs5943429; rs6568268; rs6643465; rs6655225; rs7057160; rs7881846; rs839401

# Metabolic_Enzyme_15_General_References:
9598324; 9480748; 11889465

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5843

# Metabolic_Enzyme_16_Name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

# Metabolic_Enzyme_16_Synonyms:
Cam-PDE 1A; 61 kDa Cam-PDE; hCam-1

# Metabolic_Enzyme_16_Gene_Name:
PDE1A

# Metabolic_Enzyme_16_Protein_Sequence:
>Calcium/calmodulindependent 3',5'cyclic nucleotide phosphodiesterase 1
AMGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYA
ASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFR
SIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFM
IYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTG
IMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRL
MQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMS
LILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIG
FIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKG
SMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ

# Metabolic_Enzyme_16_Number_of_Residues:
535

# Metabolic_Enzyme_16_Molecular_Weight:
61253

# Metabolic_Enzyme_16_Theoretical_pI:
6.02

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Not Available

# Metabolic_Enzyme_16_Specific_Function:
Has a higher affinity for cGMP than for cAMP

# Metabolic_Enzyme_16_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_16_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF00233:PDEase_I;
PF08499:PDEase_I_N

# Metabolic_Enzyme_16_Signals:
None

# Metabolic_Enzyme_16_Transmembrane_Regions:
None

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_16_GenBank_ID_Protein:
1151109

# Metabolic_Enzyme_16_SwissProt_ID:
PDE1A_HUMAN (P54750)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
PDE1A

# Metabolic_Enzyme_16_Geneatlas_id:
PDE1A

# Metabolic_Enzyme_16_hgnc_id:
HGNC:8774

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_16_Gene_Sequence:
>1608 bp
ATGGGGTCTAGTGCCACAGAGATTGAAGAATTGGAAAACACCACTTTTAAGTATCTTACA
GGAGAACAGACTGAAAAAATGTGGCAGCGCCTGAAAGGAATACTAAGATGCTTGGTGAAG
CAGCTGGAAAGAGGTGATGTTAACGTCGTCGACTTAAAGAAGAATATTGAATATGCGGCA
TCTGTGCTGGAAGCAGTTTATATCGATGAAACAAGAAGACTTCTGGATACTGAAGATGAG
CTCAGTGACATTCAGACTGACTCAGTCCCATCTGAAGTCCGGGACTGGTTGGCTTCTACC
TTTACACGGAAAATGGGGATGACAAAAAAGAAACCTGAGGAAAAACCAAAATTTCGGAGC
ATTGTGCATGCTGTTCAAGCTGGAATTTTTGTGGAAAGAATGTACCGAAAAACATATCAT
ATGGTTGGTTTGGCATATCCAGCAGCTGTCATCGTAACATTAAAGGATGTTGATAAATGG
TCTTTCGATGTATTTGCCCTAAATGAAGCAAGTGGAGAGCATAGTCTGAAGTTTATGATT
TATGAACTGTTTACCAGATATGATCTTATCAACCGTTTCAAGATTCCTGTTTCTTGCCTA
ATCACCTTTGCAGAAGCTTTAGAAGTTGGTTACAGCAAGTACAAAAATCCATATCACAAT
TTGATTCATGCAGCTGATGTCACTCAAACTGTGCATTACATAATGCTTCATACAGGTATC
ATGCACTGGCTCACTGAACTGGAAATTTTAGCAATGGTCTTTGCTGCTGCCATTCATGAT
TATGAGCATACAGGGACAACAAACAACTTTCACATTCAGACAAGGTCAGATGTTGCCATT
TTGTATAATGATCGCTCTGTCCTTGAGAATCACCACGTGAGTGCAGCTTATCGACTTATG
CAAGAAGAAGAAATGAATATCTTGATAAATTTATCCAAAGATGACTGGAGGGATCTTCGG
AACCTAGTGATTGAAATGGTTTTATCTACAGACATGTCAGGTCACTTCCAGCAAATTAAA
AATATAAGAAACAGTTTGCAGCAGCCTGAAGGGATTGACAGAGCCAAAACCATGTCCCTG
ATTCTCCACGCAGCAGACATCAGCCACCCAGCCAAATCCTGGAAGCTGCATTATCGGTGG
ACCATGGCCCTAATGGAGGAGTTTTTCCTGCAGGGAGATAAAGAAGCTGAATTAGGGCTT
CCATTTTCCCCACTTTGTGATCGGAAGTCAACCATGGTGGCCCAGTCACAAATAGGTTTC
ATCGATTTCATAGTAGAGCCAACATTTTCTCTTCTGACAGACTCAACAGAGAAAATTGTT
ATTCCTCTTATAGAGGAAGCCTCAAAAGCCGAAACTTCTTCCTATGTGGCAAGCAGCTCA
ACCACCATTGTGGGGTTACACATTGCTGATGCACTAAGACGATCAAATACAAAAGGCTCC
ATGAGTGATGGGTCCTATTCCCCAGACTACTCCCTTGCAGCAGTGGACCTGAAGAGTTTC
AAGAACAACCTGGTGGACATCATTCAGCAGAACAAAGAGAGGTGGAAAGAGTTAGCTGCA
CAAGAAGCAAGAACCAGTTCACAGAAGTGTGAGTTTATTCATCAGTAA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
U40370

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_16_Locus:
2q32.1

# Metabolic_Enzyme_16_SNPs:
rs6749969; rs6734868; rs1432531; rs1999; rs28364747; rs2368253; rs1196064; rs1430163; rs833149; rs2623431; rs964758; rs833182; rs1430143; rs2623423; rs1432534; rs964757; rs833166; rs833142; rs1864852; rs1430142; rs718448; rs1196065; rs1383898; rs1438072; rs1432520; rs833175; rs2623421; rs1430145; rs2368252; rs1367201; rs1347079; rs2568664; rs1367202; rs1196062; rs1988750; rs2368301; rs1864850; rs1432523; rs1991765; rs2128043; rs1196060; rs833152; rs1370666; rs1370669; rs1196058; rs1430162; rs1835881; rs1864849; rs1432517; rs2568672; rs2623436; rs1196059; rs2860078; rs2887202; rs1432521; rs1864855; rs1946815; rs2623438; rs2568675; rs833178; rs2568667; rs1432522; rs833123; rs833115; rs1564542; rs2170403; rs833122; rs833179; rs1560371; rs10931010; rs12474760; rs2128046; rs10931015; rs1992183; rs2887217; rs7598327; rs994155; rs1864847; rs833134; rs11690832; rs833125; rs4629124; rs10930998; rs12468232; rs1864853; rs10497604; rs2368296; rs1432533; rs3769801; rs833148; rs10931009; rs1432515; rs12466618; rs11683479; rs2118484; rs1438065; rs3769806; rs1196074; rs12624259; rs1560370; rs2568663; rs4666828; rs1595450; rs12465662; rs1946602; rs833124; rs2368294; rs12328342; rs4503956; rs10931016; rs7583421; rs6741055; rs2887218; rs10930999; rs6433976; rs4644985; rs10181526; rs2577659; rs3769788; rs11689230; rs1125184; rs7597711; rs1991596; rs300885; rs6740124; rs6706326; rs7589989; rs6759303; rs2128042; rs6760317; rs833118; rs7581210; rs10931002; rs1344772; rs833145; rs6719036; rs13034133; rs2368255; rs12693302; rs12474820; rs11891890; rs10193166; rs1430144; rs4643498; rs10930997; rs7593755; rs12468743; rs12693301; rs10931013; rs11884886; rs13036034; rs1430160; rs6759413; rs9789764; rs6433974; rs1481630; rs6740244; rs7597380; rs1370668; rs4666585; rs833126; rs2164861; rs1346775; rs6721984; rs833130; rs2887200; rs11679657; rs6759450; rs3769809; rs991927; rs10931022; rs10178586; rs833113; rs1196067; rs10930993; rs1594615; rs10197295; rs4666836; rs12996836; rs2623437; rs2368298; rs10184548; rs1430157; rs10931008; rs2368256; rs6718589; rs10206828; rs753289; rs1991766; rs1430159; rs12612546; rs6433959; rs833119; rs934260; rs10206325; rs1438069; rs1370667; rs4666835; rs3754929; rs11902391; rs1594304; rs1438071; rs724851; rs1864445; rs4666819; rs6758334; rs9653242; rs2577661; rs11899043; rs833141; rs2623409; rs11676337; rs1594617; rs10930991; rs6736414; rs7558737; rs3769791; rs1196066; rs7569537; rs4666815; rs1021090; rs833168; rs7585752; rs1438070; rs833140; rs2082135; rs9784041; rs4666582; rs1370665; rs2195878; rs12473534; rs12475647; rs10169102; rs11883669; rs10931012; rs12622714; rs2368295; rs12477696; rs13400536; rs12474371; rs10204284; rs4666817; rs833156; rs6433973; rs12477494; rs11892984; rs6734447; rs13406145; rs12693300; rs934261; rs1594305; rs7606428; rs7557419; rs1368216; rs17343416; rs2568681; rs1367203; rs11674335; rs11692649; rs16823044; rs13400054; rs4572561; rs7592850; rs934264; rs833135; rs6715692; rs1367204; rs1210652; rs6750552; rs11684934; rs1560372; rs7571503; rs11690257; rs2128045; rs16823102; rs833176; rs11686025; rs6433958; rs833138; rs3769803; rs4496292; rs12693299; rs17356152; rs11887327; rs10497605; rs12467240; rs2623432; rs12693308; rs12475048; rs12468346; rs13410344; rs13392487; rs7562805; rs12616214; rs6747821; rs12621579; rs7599577; rs4666827; rs4335909; rs11682598; rs11898512; rs11894978; rs17265405; rs1432518; rs2368278; rs1560375; rs10197136; rs11691411; rs11886669; rs2082136; rs1564543; rs11887703; rs17343395; rs6728410; rs1897104; rs1864851; rs4666587; rs10931020; rs16823124; rs833162; rs2368299; rs864417; rs2368300; rs17265322; rs833154; rs833146; rs12479259; rs12617420; rs6760364; rs6433964; rs11900878; rs16823319; rs833117; rs6728235; rs10186868; rs1196069; rs10803955; rs1432519; rs2368254; rs2623410; rs9288080; rs1594618; rs1967008; rs13417045; rs16823047; rs2368277; rs12469500; rs3769796; rs2623430; rs3769800; rs11684406; rs6757164; rs2170400; rs10174383; rs12989198; rs7574051; rs2170402; rs16823122; rs1021092; rs6724256; rs11892848; rs10931000; rs10497601; rs16822799; rs11884145; rs1471587; rs2368297; rs16823179; rs12693305; rs1583112; rs6726121; rs17356200; rs3769802; rs17356207; rs10497597; rs6740401; rs16823171; rs13432152; rs10497595; rs13417404; rs10171703; rs1842640; rs6433960; rs6433963; rs3769811; rs7585427; rs12467526; rs11895738; rs1347732; rs1196072; rs3769789; rs3769810; rs12617844; rs9288081; rs2368302; rs2568673; rs17366198; rs11675519; rs12994855; rs12477627; rs1549870; rs10207132; rs10497600; rs6740226; rs12693304; rs4666584; rs7595025; rs16823163; rs10497602; rs1430146; rs10930995; rs11678230; rs1595448; rs6740889; rs4666851; rs7567023; rs3820963; rs7563753; rs7578466; rs10931014; rs1196070; rs12693303; rs12466937; rs10169895; rs11681840; rs3769792; rs17356303; rs12470644; rs3940474; rs833174; rs1594614; rs11891405; rs11677155; rs13420620; rs833180; rs2276612; rs833128; rs11895090; rs2099185; rs10931017; rs11888602; rs833177; rs17356166; rs17265294; rs10209382; rs10497603; rs11690037; rs16823254; rs12693307; rs833170; rs7567423; rs7597921; rs1346773; rs16823201; rs1438068; rs1595449; rs1897472; rs2368280; rs4666846; rs1430141; rs4666578; rs12616751; rs10497599; rs17366503; rs4480955; rs7578703; rs10206152; rs10931011; rs9332425; rs3856410; rs833160; rs2195611; rs16823011; rs7422491; rs10497598; rs16823106; rs3769794; rs17264929; rs833158; rs833120; rs11677310; rs833181; rs10174618; rs7606875; rs12693306; rs1595445; rs2623435; rs6733603; rs6733935; rs6751445; rs11686989; rs1864854; rs17457136; rs2887199; rs11687469; rs11678901; rs10196288; rs6720739; rs4666845; rs2568674; rs2196695; rs11893572; rs7601804; rs4666583; rs10930992; rs7561341; rs10180233; rs1594306; rs11678804; rs13410259; rs7591292; rs833114; rs4666579; rs2368276; rs833159; rs1196073; rs2128047; rs16823207; rs17457303; rs6729400; rs833116; rs2448980; rs13385209; rs2577649; rs2623418; rs12990168; rs13399478; rs12470722; rs1898591; rs833155; rs2887207; rs4666844; rs2568677; rs7597403; rs2118485; rs7591416; rs6720942; rs2623422; rs2053270; rs1121403; rs12612357; rs13020976; rs16822749; rs2577658; rs12616179; rs4594404; rs6760589; rs16823184; rs16822776; rs10197132; rs6747822; rs11678948; rs7606009; rs16823203; rs12468333; rs1438073; rs2623417; rs16823235; rs9711046; rs1383899; rs16823222; rs2568661; rs12622605; rs2368279; rs6726324; rs6718641; rs2568684; rs16823233; rs16823317; rs17265027; rs16823287; rs6728985; rs6761081; rs10198076; rs4091077; rs16823182; rs1481629; rs16822886; rs833165; rs34053285; rs6709051; rs12616229; rs16823234; rs4666834; rs16823275; rs3820962; rs6730984; rs2623412; rs2568670; rs9753060; rs16823678; rs16822961; rs12475637; rs16822915; rs11690853; rs12987958; rs16823010; rs4666841; rs833147; rs2217614; rs2438288; rs1837167; rs4630732; rs1196068; rs4666850; rs1438075; rs2118487; rs833139; rs13030388; rs16823686; rs17265041; rs6751461; rs16823220; rs11687076; rs2448982; rs17265061; rs11685463; rs1432525; rs10165500; rs9753059; rs16823199; rs17343304; rs1430150; rs12988258; rs10182266; rs17343311; rs34103461; rs17356331; rs11677543; rs6744832; rs16823243; rs4555308; rs13388594; rs16822745; rs7578481; rs6433970; rs6714282; rs16823257; rs4383292; rs833127; rs17265166; rs13428559; rs11681620; rs1438074; rs17264796; rs1344773; rs300884; rs12470801; rs17457344; rs1196063; rs1560374; rs3769778; rs13400663; rs13397213; rs6729405; rs2448981; rs10188331; rs2568687; rs13388711; rs833144; rs833163; rs17356296; rs12470124; rs4666586; rs10200242; rs16822895; rs6717783; rs3769805; rs12465755; rs1583114; rs12478553; rs13388735; rs2577651; rs10181570; rs13383296; rs12472694; rs4583416; rs833173; rs17265189; rs16822899; rs12615015; rs16823227; rs17343318; rs724376; rs17356463; rs10209868; rs2568665; rs7589555; rs17595927; rs6754260; rs2568680; rs1430161; rs6725769; rs17265350; rs17410250; rs866732; rs1430147; rs10199957; rs10185985; rs3769790; rs1432516; rs2623426; rs4666820; rs6705950; rs4666824; rs4666829; rs11677136; rs2082134; rs1430148; rs2623420; rs17265203; rs6718531; rs12469046; rs711807; rs6741105; rs2099184; rs4666840; rs6720671; rs833151; rs16823249; rs7592388; rs10209197; rs4583421; rs2577663; rs13024682; rs13398665; rs7588289; rs2170401; rs2887215; rs11695445; rs10171911; rs12478132; rs11674733; rs4318355; rs4666823; rs4632308; rs12614214; rs2568666; rs16823156; rs10930996; rs17264887; rs10201929; rs17264880; rs1542584; rs2577652; rs2623427; rs10185590; rs1988751; rs7595111; rs6721940; rs11677709; rs1430158; rs11899588; rs7567112; rs833131; rs2568671; rs711806; rs11903131; rs13407156; rs833153; rs1595446; rs17356214; rs10189043; rs2568683; rs16823229; rs12473820; rs4018737; rs865001; rs17457323; rs13035314; rs12465757; rs833157; rs17595863; rs6758298; rs10803956; rs11683084; rs16823120; rs16822892; rs833167; rs16822918; rs2438290; rs16823168; rs6747766; rs4666580; rs7589514; rs4666830; rs16823151; rs1864848; rs10202082; rs3769797; rs10195640; rs2568676; rs11685510; rs4666838; rs4666822; rs4666826; rs16823150; rs17264894; rs16822889; rs10931018; rs833172; rs11887150; rs10497596; rs16823277; rs3769786; rs7561075; rs11676559; rs13394418; rs16823285; rs4018730; rs167284; rs833171; rs2623439; rs17457164; rs9798118; rs16823236; rs6734150; rs13403591; rs10207047; rs2577660; rs964756; rs16822768; rs711808; rs17265384; rs12621190; rs4666837; rs10198216; rs13406342; rs17366218; rs10200025; rs833150; rs16823158; rs1438067; rs9711070; rs4666825; rs6720583; rs2568660; rs10175845; rs1351492; rs2128044; rs10931021; rs865578; rs7560332; rs13003148; rs3769779; rs4666577; rs2303890; rs3754928; rs1921153; rs12105839; rs17649281; rs1057945; rs5836825; rs3210428; rs2276613; rs34657010; rs1484; rs34392771; rs1560373; rs35704530; rs13016087; rs2568662; rs28870438; rs1142499; rs7591196; rs3063101; rs10204911; rs13021857; rs35927091; rs10195097; rs10184869; rs1438066; rs35087060; rs34269574; rs5836832; rs34206320; rs34200314; rs7608624; rs34318365; rs36099854; rs11376015; rs35771061; rs3835906; rs13404757; rs13410703; rs13397815; rs34744930; rs13391931; rs10667573; rs35084880; rs35321986; rs34436167; rs35061201; rs34978102; rs16823159; rs35932804; rs34981789; rs35467151; rs34523452; rs35075463; rs36067516; rs34934382; rs13025145; rs28369479; rs33922098; rs16822795; rs11336735; rs13418736; rs11376014; rs9712068; rs35204121; rs34884579; rs35019955; rs10432427; rs35032256; rs833164; rs34538059; rs2118486; rs33987953; rs35764937; rs4544391; rs6728245; rs4505483; rs35247872; rs35851840; rs5836827; rs3769787; rs13411042; rs13402461; rs16822784; rs2577648; rs34602848; rs6707322; rs35760311; rs1196075; rs34257247; rs16822812; rs4666818; rs35372886; rs3835908; rs1142496; rs5004861; rs17264817; rs34418595; rs2217424; rs36079245; rs34716524; rs5836830; rs13403996; rs1346774; rs35239912; rs33944928; rs34241797; rs3835905; rs13405173; rs10546002; rs10182192; rs13020356; rs10679939; rs2163695; rs35081866; rs35642510; rs9752179; rs6736660; rs11329645; rs12623018; rs34497200; rs10661926; rs13012803; rs6720202; rs34799454; rs35092643; rs12995785; rs34735471; rs13015852; rs16823072; rs6712992; rs34157460; rs7581170; rs6759207; rs35485908; rs34120183; rs11351148; rs34225086; rs35394100; rs6740676; rs35825733; rs35806345; rs34219838; rs3209104; rs28569979; rs4666581; rs28701896; rs34165544; rs11677223; rs35777140; rs12991791; rs3835907; rs11333920; rs34505391; rs35030431; rs28420082; rs2195880; rs6729094; rs833132; rs35600244; rs10649015; rs6147058; rs36120860; rs13028649; rs13413938; rs36047430; rs35608334; rs3062171; rs35164921; rs34487617; rs12988815; rs1196061; rs35122269; rs13012388; rs35843666; rs7601239; rs34665608; rs4666833; rs34868101; rs13410842; rs35797263; rs5836834; rs13001576; rs6734332; rs35829416; rs34388968; rs11675803; rs11348029; rs300882; rs1816654; rs3209105; rs35327523; rs35226392; rs16822851; rs5836829; rs9798131; rs13416498; rs34670464; rs34307690; rs35470057; rs28807785; rs35161948; rs34156888; rs34185607; rs34636057; rs11394200; rs34019486; rs10632753; rs13393694; rs16822739; rs35085933; rs12470794; rs35219304; rs35928664; rs34461539; rs6433975; rs9678854; rs35176528; rs6748063; rs11349101; rs11442872; rs10173255; rs13017441; rs34780932; rs34850993; rs3940475; rs6761344; rs12104898; rs35169307; rs28439754; rs35840738; rs34929129; rs10529301; rs34483465; rs34669140; rs36010429; rs833133; rs2887208; rs36059127; rs866733; rs5836833; rs9712067; rs833136; rs13035123; rs34344623; rs3769795; rs35131293; rs16822753; rs35577192; rs2577654; rs36212772; rs12053027; rs833143; rs34167707; rs28820373; rs10595375; rs13033301; rs922732; rs2568682; rs35196240; rs4369824; rs4666852; rs34173972; rs10176807; rs34393660; rs13402892; rs34377459; rs10626467; rs11349102; rs34133532; rs34963796; rs34609810; rs11420985; rs34296220; rs11681511; rs34674764; rs28773524; rs34846500; rs10691371; rs28520932; rs35187563; rs16822777; rs34224743; rs300883; rs34172306; rs34236186; rs35764684; rs11379999; rs13025112; rs11375672; rs10590540; rs16823164; rs13399931; rs34299616; rs2577655; rs2577664; rs36121688; rs1835880; rs3062169; rs34348001; rs300887; rs4144788; rs12991955; rs34933688; rs13407411; rs41371048; rs34592316; rs34213407; rs34146836; rs12474205; rs16822938; rs922731; rs35256698; rs11688020; rs35022988; rs12104910; rs34388312; rs35336295; rs10209574; rs13410856; rs34087191; rs35208422; rs13387701; rs1432532; rs10601832; rs13430558; rs5836836; rs35607749; rs34346085; rs34057444; rs28408366; rs28836623; rs35242356; rs13004142; rs28828218; rs11340321; rs2368275; rs6755854; rs35361731; rs833169; rs16822963; rs10552886; rs36094848; rs34164863; rs13008937; rs4018725; rs1469638; rs1142494; rs7423835; rs300881; rs34889222; rs35002581; rs13013571; rs34988767; rs13424576; rs35852909; rs1595447; rs16822803; rs28666451; rs4144787; rs1070197; rs10688734; rs2438291; rs16823231; rs35368292; rs34226756; rs35220243; rs6760081; rs9711065; rs11399196; rs2082137; rs34920104; rs34966344; rs10713794; rs3209106; rs35811506; rs10931019; rs13400207; rs36105371; rs10177393; rs35509004; rs1978701; rs13415219; rs6760333; rs35831447; rs1142493; rs12999222; rs7606819; rs35650373; rs35320184; rs10557808; rs12996626; rs11408095; rs35174498; rs34076997; rs34640250; rs16822975; rs5836835; rs7423272; rs34245450; rs10203701; rs3063250; rs10188098; rs6147057; rs2436223; rs34863201; rs34103776; rs35115213; rs1196071; rs16822843; rs34713018; rs34586550; rs7425918; rs3835909; rs13013920; rs34863701; rs35574967; rs13424577; rs6761816; rs300886; rs10710872; rs34237746; rs35357239; rs16822827; rs300889; rs3769798; rs10586379; rs2116637; rs866238; rs35885421; rs3063230; rs13384332; rs34509021; rs34758055; rs833121; rs34957815; rs35323523; rs28409316; rs1595444; rs11319157; rs34530868; rs11296923; rs35392282; rs28715871; rs12991803; rs4018724; rs34681555; rs34371581; rs35441240; rs2577653; rs36076255; rs34984539; rs35111823; rs10664174; rs34245807; rs28584604; rs35648980; rs34968173; rs6759848; rs34116983; rs2116636; rs7579614; rs35587614; rs35425419; rs300888; rs34132592; rs35774261; rs34921672; rs34853053; rs35202585; rs36010777; rs35453967; rs2623424; rs10716042; rs11314814; rs34710050; rs34134272; rs35055482; rs35368132; rs7424126; rs34034865; rs13387603; rs13388823; rs35927887; rs36032833; rs11431216; rs35840080; rs10549191; rs28483774; rs9789594; rs13387691; rs13421087; rs34661945; rs10592313; rs34302168; rs34157620; rs34107698; rs28627441; rs4497838; rs11444937; rs12053043; rs2887216; rs12991790; rs3948378; rs5836826; rs34010252; rs862914; rs35884831; rs10170443; rs34823032; rs3063102; rs35502150; rs1837166; rs35617426; rs4992784; rs1871805; rs34343334; rs34450309; rs9653243; rs13420210; rs9798127; rs16823040; rs36202824; rs10597484; rs13013738; rs3830245; rs11300978; rs35182213; rs11351500; rs35809203; rs34641892; rs34558843; rs6725460; rs2116635; rs35245337; rs10617879; rs13026153; rs6719467; rs34326436; rs34145505; rs1142495; rs10668596; rs35156194; rs12472990; rs34384812; rs35828806; rs833161; rs34841932; rs1842639; rs11405472; rs6731653; rs34878038; rs35827784; rs4666821; rs11420821; rs2438289; rs16823144; rs5836837; rs1430149; rs4425048; rs16822903; rs34934165; rs34382403; rs34234948; rs9678855; rs6736970; rs11414637; rs35139583; rs3769799; rs6759212; rs1383900; rs2568686; rs35067674; rs6747943; rs34461180; rs35248394; rs34181578; rs10197337; rs11676428; rs1196057; rs12464556; rs13001068; rs13027181; rs1347081; rs1368217; rs1368218; rs1368219; rs1368220; rs1368221; rs1432528; rs1432529; rs17649232; rs2115863; rs2217616; rs4257360; rs6711862; rs6726543; rs6756014; rs720245; rs7580253; rs7584728; rs7592780

# Metabolic_Enzyme_16_General_References:
8557689; 11342109; 11747989

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5844

# Metabolic_Enzyme_17_Name:
Ubiquitin-conjugating enzyme E2 D1

# Metabolic_Enzyme_17_Synonyms:
Ubiquitin-protein ligase D1; Ubiquitin carrier protein D1; UbcH5; Ubiquitin- conjugating enzyme E2-17 kDa 1; E2(17KB 1

# Metabolic_Enzyme_17_Gene_Name:
UBE2D1

# Metabolic_Enzyme_17_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 D1
MALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDY
PFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLV
PDIAQIYKSDKEKYNRHAREWTQKYAM

# Metabolic_Enzyme_17_Number_of_Residues:
147

# Metabolic_Enzyme_17_Molecular_Weight:
16602

# Metabolic_Enzyme_17_Theoretical_pI:
7.50

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Not Available

# Metabolic_Enzyme_17_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53

# Metabolic_Enzyme_17_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_17_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_17_Signals:
None

# Metabolic_Enzyme_17_Transmembrane_Regions:
None

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_17_GenBank_ID_Protein:
460810

# Metabolic_Enzyme_17_SwissProt_ID:
UB2D1_HUMAN (P51668)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
UBE2D1

# Metabolic_Enzyme_17_Geneatlas_id:
UBE2D1

# Metabolic_Enzyme_17_hgnc_id:
HGNC:12474

# Metabolic_Enzyme_17_PDB_ID:
1Z2U

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Not Available

# Metabolic_Enzyme_17_Gene_Sequence:
>444 bp
ATGGCGCTGAAGAGGATTCAGAAAGAATTGAGTGATCTACAGCGCGATCCACCTGCTCAC
TGTTCAGCTGGACCTGTGGGAGATGACTTGTTCCACTGGCAAGCCACTATTATGGGGCCT
CCTGATAGCGCATATCAAGGTGGAGTCTTCTTTCTCACTGTACATTTTCCGACAGATTAT
CCTTTTAAACCACCAAAGATTGCTTTCACAACAAAAATTTACCATCCAAACATAAACAGT
AATGGAAGTATTTGTCTCGATATTCTGAGGTCACAATGGTCACCAGCTCTGACTGTATCA
AAAGTTTTATTGTCCATATGTTCTCTACTTTGTGATCCTAATCCAGATGACCCCTTAGTA
CCAGATATTGCACAAATCTATAAATCAGACAAAGAAAAATACAACAGACATGCAAGAGAA
TGGACTCAGAAATATGCAATGTAA

# Metabolic_Enzyme_17_GenBank_ID_Gene:
X78140

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_17_Locus:
10q11.2-q21

# Metabolic_Enzyme_17_SNPs:
rs7084674; rs1905455; rs1963927; rs10826174; rs11006121; rs4948291; rs10733980; rs4145785; rs11593650; rs3802699; rs10509089; rs11599360; rs7907725; rs10826172; rs9663811; rs7907716; rs10826173; rs11006122; rs7912527; rs16912161; rs16912155; rs2306605; rs11006113; rs11006120; rs7069613; rs12250046; rs16912166; rs11818745; rs16912153; rs11597042; rs16912160; rs12255735; rs7067670; rs28365823; rs34913574; rs11336978; rs34415625; rs12768363; rs35713196; rs35409288; rs12259285; rs11285375; rs36085642; rs34565317; rs10708236; rs34044230; rs34007991; rs34893503; rs35112740; rs11006115; rs12358567; rs34101372; rs11006123; rs11006117; rs33976064; rs11595502; rs35745962; rs11597039; rs7080053; rs35662901; rs34658838; rs11284386; rs3885750; rs41307530; rs34305911; rs35324479; rs34832174; rs41307528; rs5785315; rs7905938; rs12245963; rs1905456; rs12358693; rs34790413; rs12766129; rs11301989; rs34574089; rs34350845; rs1007915; rs10826175; rs11006111; rs11006112; rs11006124; rs12241885; rs12262648; rs16912171; rs16912172; rs1994174; rs4439463; rs7085229; rs7085740; rs7086017

# Metabolic_Enzyme_17_General_References:
8090726; 11389839

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5507

# Metabolic_Enzyme_18_Name:
Phenylalanyl-tRNA synthetase, mitochondrial precursor

# Metabolic_Enzyme_18_Synonyms:
Phenylalanine--tRNA ligase; PheRS

# Metabolic_Enzyme_18_Gene_Name:
FARS2

# Metabolic_Enzyme_18_Protein_Sequence:
>PhenylalanyltRNA synthetase, mitochondrial precursor
MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQ
DDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVV
TTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRR
DQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVE
FDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVN
SAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKY
PAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRH
MERTLSQREVRHIHQALQEAAVQLLGVEGRF

# Metabolic_Enzyme_18_Number_of_Residues:
451

# Metabolic_Enzyme_18_Molecular_Weight:
52357

# Metabolic_Enzyme_18_Theoretical_pI:
7.48

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  phenylalanine-tRNA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  phenylalanyl-tRNA aminoacylation
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_18_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_18_Specific_Function:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

# Metabolic_Enzyme_18_Pathway:
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_18_Reaction:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF03147:FDX-ACB;
PF01409:tRNA-synt_2d

# Metabolic_Enzyme_18_Signals:
None

# Metabolic_Enzyme_18_Transmembrane_Regions:
None

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 6.1.1.20

# Metabolic_Enzyme_18_GenBank_ID_Protein:
3983103

# Metabolic_Enzyme_18_SwissProt_ID:
SYFM_HUMAN (O95363)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
FARS2

# Metabolic_Enzyme_18_Geneatlas_id:
FARS2

# Metabolic_Enzyme_18_hgnc_id:
HGNC:21062

# Metabolic_Enzyme_18_PDB_ID:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Mitochondrion; mitochondrial matrix (Potential)

# Metabolic_Enzyme_18_Gene_Sequence:
>1356 bp
ATGGTGGGCTCAGCTCTCAGGAGAGGTGCCCATGCATATGTCTACCTGGTGAGTAAGGCC
AGTCACATCTCCAGAGGCCATCAGCACCAGGCCTGGGGATCGAGGCCTCCTGCAGCAGAG
TGTGCCACCCAAAGAGCTCCAGGCAGTGTGGTGGAGCTGCTGGGCAAATCCTACCCTCAG
GACGACCACAGCAACCTCACCCGGAAGGTCCTCACCAGAGTTGGCAGGAACCTGCACAAC
CAGCAGCATCACCCTCTGTGGCTGATCAAGGAGAGGGTGAAGGAGCACTTCTACAAGCAG
TATGTGGGCCGCTTTGGGACCCCGTTGTTCTCGGTCTACGACAACCTTTCTCCAGTGGTC
ACGACCTGGCAGAACTTTGACAGCCTGCTCATCCCAGCTGATCACCCCAGCAGGAAGAAG
GGGGACAACTATTACCTGAATCGGACTCACATGCTGAGAGCGCACACGTCTGCACACCAG
TGGGACTTGCTGCACGCGGGACTGGATGCCTTCCTGGTGGTGGGTGATGTCTACAGGCGT
GACCAGATCGACTCCCAGCACTACCCTATTTTCCACCAGCTGGAGGCCGTGCGGCTCTTC
TCCAAGCATGAGTTATTTGCTGGTATAAAGGATGGAGAAAGCCTGCAGCTCTTTGAACAA
AGTTCTCGCTCTGCGCATAAACAAGAGACACACACCATGGAGGCCGTGAAGCTTGTAGAG
TTTGATCTTAAGCAAACGCTTACCAGGCTCATGGCACATCTTTTTGGAGATGAGCTGGAG
ATAAGATGGGTAGACTGCTACTTCCCTTTTACACATCCTTCCTTTGAGATGGAGATCAAC
TTTCATGGAGAATGGCTGGAAGTTCTTGGCTGCGGGGTGATGGAACAACAACTGGTCAAT
TCAGCTGGTGCTCAAGACCGAATCGGCTGGGCTTTTGGCCTAGGATTAGAAAGGCTAGCC
ATGATCCTCTACGACATCCCTGATATCCGTCTCTTCTGGTGTGAGGACGAGCGCTTCCTG
AAGCAGTTCTGTGTATCCAACATTAATCAGAAGGTGAAGTTTCAGCCTCTTAGCAAATAT
CCGGCTGTGATCAATGATATTTCATTCTGGTTGCCCTCTGAGAATTACGCAGAAAATGAT
TTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATCTCATAGAC
AAGTTTGTACATCCAAAGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCAC
ATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCCTTGCAGGAGGCT
GCAGTCCAGCTGTTGGGTGTGGAGGGCAGGTTCTGA

# Metabolic_Enzyme_18_GenBank_ID_Gene:
AF097441

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_18_Locus:
6p25.1

# Metabolic_Enzyme_18_SNPs:
Not Available

# Metabolic_Enzyme_18_General_References:
10329163; 14574404

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5845

# Metabolic_Enzyme_19_Name:
GTP:AMP phosphotransferase mitochondrial

# Metabolic_Enzyme_19_Synonyms:
Adenylate kinase 3; AK3; Adenylate kinase 3 alpha-like 1

# Metabolic_Enzyme_19_Gene_Name:
AK3

# Metabolic_Enzyme_19_Protein_Sequence:
>GTP:AMP phosphotransferase mitochondrial
MGASARLLRAVIMGAPGSGKGTVSSRITTHFELKHLSSGDLLRDNMLRGTEIGVLAKAFI
DQGKLIPDDVMTRLALHELKNLTQYSWLLDGFPRTLPQAEALDRAYQIDTVINLNVPFEV
IKQRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQREDDKPETVIKRLKAYEDQT
KPVLEYYQKKGVLETFSGTETNKIWPYVYAFLQTKVPQRSQKASVTP

# Metabolic_Enzyme_19_Number_of_Residues:
227

# Metabolic_Enzyme_19_Molecular_Weight:
25566

# Metabolic_Enzyme_19_Theoretical_pI:
9.64

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  adenylate kinase activity
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleotide kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_19_Specific_Function:
NTP + AMP = NDP + ADP

# Metabolic_Enzyme_19_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_19_Reaction:
nucleoside triphosphate + AMP = nucleoside diphosphate + ADP

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF00406:ADK;
PF05191:ADK_lid

# Metabolic_Enzyme_19_Signals:
None

# Metabolic_Enzyme_19_Transmembrane_Regions:
None

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 2.7.4.10

# Metabolic_Enzyme_19_GenBank_ID_Protein:
6518533

# Metabolic_Enzyme_19_SwissProt_ID:
KAD3_HUMAN (Q9UIJ7)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
AK3

# Metabolic_Enzyme_19_Geneatlas_id:
AK3

# Metabolic_Enzyme_19_hgnc_id:
HGNC:17376

# Metabolic_Enzyme_19_PDB_ID:
2AK3

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_19_Gene_Sequence:
>684 bp
ATGGGGGCGTCGGGGCGGCTGCTGCGAGCGGTGATCATGGGGGCCCCGGGCTCGGGCAAG
GGCACCGTGTCGTCCCGCATCACTACACACTTCGAGCTGAAGCACCTCTCCCGCGGGGAC
CTGCTCCGGGACAACATGCTGCGGGGCACAGAAATTGGCGTGTTAGCCCAGGCTTTCATT
GACCAAGGGAAACTCATCCCAGATTATGTCACGACTCGGCTGGCCCTTCATGAGCTGAAA
AACCTCACCCAGTATAGCTGGCTGTTGGATGGTTTTCCAAGGACACTTCCACAGGCAGAA
GCCCTAGATAGAGCTTATCAGATCGACACAGTGATTAACCTGAATGTGCCCTTTGAGGTC
ATTAAACAACGCCTTACTGCTCGCTGGATTCATCCCGCCAGTGGCCGAGTCTATAACATT
GAATTCAACCCTCCCAAAACTGTGGGCATTGATGACCTGACTGGGGAGCCTCTCATTCAG
CGTGAGGATGATAAACCAGAGACGGTTATCAAGAGACTAAAGGCTTATGAAGACCAAACA
AAGCCAGTCCTGGAATATTACCAGAAAAAAGGGGTGTTGGAAACATTCTCCGGAACAGAA
ACCAACAAGATTTGGCCCTATGTATATGCTTTCCTACAAACTAAAGTTCCACAAAGAAGC
CAGAAAGCTTCAGTTACTCCATGA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
AB021870

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_19_Locus:
9p24.1-p24.3

# Metabolic_Enzyme_19_SNPs:
rs6915; rs7839; rs296826; rs611315; rs458853; rs387413; rs461283; rs465793; rs456374; rs6476897; rs10758645; rs6476896; rs7025342; rs7042425; rs407603; rs2274820; rs425797; rs439786; rs7029401; rs465514; rs412523; rs7025999; rs464159; rs2274821; rs12684274; rs407872; rs10815060; rs9299003; rs7874642; rs12685446; rs3847259; rs3858043; rs296827; rs499012; rs10116645; rs2989447; rs10118317; rs11795106; rs7033866; rs10118863; rs12684167; rs3847258; rs12683352; rs10758646; rs1756867; rs439021; rs403860; rs2150614; rs16921966; rs10122675; rs12684173; rs2039300; rs467215; rs3818669; rs435100; rs429491; rs6476904; rs10815062; rs2989446; rs2183668; rs382034; rs10122182; rs12683953; rs7850522; rs378470; rs7033631; rs296882; rs10974756; rs7862134; rs7036553; rs10122575; rs463684; rs466740; rs7036255; rs17761666; rs468822; rs12378955; rs393097; rs2183670; rs10974751; rs7029742; rs10974754; rs406632; rs7856334; rs10121986; rs10974761; rs371053; rs10117047; rs10124194; rs6476903; rs1756865; rs13295366; rs382481; rs10974746; rs7034145; rs456549; rs431438; rs9918953; rs4286995; rs7875108; rs10815063; rs296881; rs393421; rs525055; rs413530; rs10118925; rs10122113; rs7872160; rs10124193; rs10974749; rs4484749; rs10974759; rs6476898; rs403873; rs7871915; rs12156500; rs466300; rs10121478; rs4500134; rs459122; rs35554426; rs12341359; rs410951; rs16921989; rs10115632; rs12350463; rs10118291; rs439486; rs439660; rs434892; rs10124574; rs10974747; rs6476902; rs378117; rs1048020; rs389445; rs1009447; rs1556362; rs159878; rs377430; rs414762; rs12003384; rs376680; rs17717946; rs296823; rs440497; rs375743; rs3808855; rs3808857; rs301490; rs301491; rs301492; rs403347; rs370932; rs11539608; rs14887; rs11539606; rs10262; rs12351140; rs14886; rs1047899; rs10974744; rs8525; rs28809001; rs7861716; rs34206656; rs10974748; rs10122613; rs28522705; rs10974760; rs415732; rs35166076; rs34481130; rs376367; rs34529377; rs33948374; rs12686844; rs1272932; rs35843737; rs12376372; rs34826468; rs443706; rs374981; rs10124593; rs13292541; rs12379614; rs34480399; rs12347371; rs10121108; rs35845464; rs2776772; rs445641; rs384562; rs33935556; rs447785; rs417364; rs35400602; rs4394450; rs413085; rs12555579; rs28848001; rs35846560; rs34098407; rs12683000; rs28670065; rs10974755; rs412899; rs28848329; rs388886; rs395423; rs2183669; rs4615632; rs10974758; rs7469985; rs36018610; rs34927825; rs12683859; rs33963986; rs13286573; rs439241; rs4373574; rs35637803; rs12686842; rs7852798; rs439239; rs10120222; rs12348423; rs5896090; rs35865338; rs12349358; rs12377935; rs11525119; rs12380629; rs34296493; rs397673; rs452333; rs451496; rs691770; rs35562986; rs35812152; rs4615631; rs34432519; rs12551243; rs385952; rs28478331; rs35405123; rs28503502; rs426575; rs12379929; rs364618; rs439835; rs384599; rs13440206; rs4442190; rs375090; rs489533; rs35121164; rs1756866; rs445285; rs10974757; rs13292115; rs12377966; rs1756864; rs12686158; rs7857582; rs13285417; rs7038082; rs376373; rs12380644; rs376684; rs12379674; rs35711809; rs10974762; rs7028711; rs34013706; rs1011115; rs10114246; rs1044706; rs10815058; rs10974742; rs10974763; rs11790285; rs12337281; rs12341356; rs12352353; rs12352385; rs12376425; rs1331191; rs1331192; rs14731; rs16921872; rs16921873; rs16921877; rs1888639; rs2026916; rs2181341; rs2183654; rs296820; rs296870; rs296871; rs296872; rs296873; rs296875; rs296876; rs296877; rs296879; rs3174298; rs3736839; rs395927; rs396861; rs409801; rs415094; rs4742045; rs4742046; rs692523; rs7024121; rs7029336; rs7029799; rs7036014; rs7040759; rs7468066; rs7852137; rs914285

# Metabolic_Enzyme_19_General_References:
Not Available

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
5846

# Metabolic_Enzyme_20_Name:
Tryptophanyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_20_Synonyms:
Tryptophan-- tRNA ligase; TrpRS; IFP53; hWRS

# Metabolic_Enzyme_20_Gene_Name:
WARS

# Metabolic_Enzyme_20_Protein_Sequence:
>TryptophanyltRNA synthetase, cytoplasmic
MPNSEPASLLELFNSIATQGELVRSLKAGNASKDEIDSAVKMLVSLKMSYKAAAGEDYKA
DCPPGNPAPTSNHGPDATEAEEDFVDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELINRI
ERATGQRPHHFLRRGIFFSHRDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFT
KWLQDVFNVPLVIQMTDDEKYLWKDLTLDQAYSYAVENAKDIIACGFDINKTFIFSDLDY
MGMSSGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDR
TDIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIF
LTDTAKQIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQIRKDY
TSGAMLTGELKKALIEVLQPLIAEHQARRKEVTDEIVKEFMTPRKLSFDFQ

# Metabolic_Enzyme_20_Number_of_Residues:
471

# Metabolic_Enzyme_20_Molecular_Weight:
53166

# Metabolic_Enzyme_20_Theoretical_pI:
6.15

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  tryptophan-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  tryptophanyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_20_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_20_Specific_Function:
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)

# Metabolic_Enzyme_20_Pathway:
map00380  Tryptophan metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_20_Reaction:
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00579:tRNA-synt_1b;
PF00458:WHEP-TRS

# Metabolic_Enzyme_20_Signals:
None

# Metabolic_Enzyme_20_Transmembrane_Regions:
None

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 6.1.1.2

# Metabolic_Enzyme_20_GenBank_ID_Protein:
184657

# Metabolic_Enzyme_20_SwissProt_ID:
SYWC_HUMAN (P23381)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
WARS

# Metabolic_Enzyme_20_Geneatlas_id:
WARS

# Metabolic_Enzyme_20_hgnc_id:
HGNC:12729

# Metabolic_Enzyme_20_PDB_ID:
1R6T

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_20_Gene_Sequence:
>1416 bp
ATGCCCAACAGTGAGCCCGCATCTCTGCTGGAGCTGTTCAACAGCATCGCCACACAAGGG
GAGCTCGTAAGGTCCCTCAAAGCGGGAAATGCGTCAAAGGATGAAATTGATTCTGCAGTA
AAGATGTTGGTGTCATTAAAAATGAGCTACAAAGCTGCCGCGGGGGAGGATTACAAGGCT
GACTGTCCTCCAGGGAACCCAGCACCTACCAGTAATCATGGCCCAGATGCCACAGAAGCT
GAAGAGGATTTTGTGGACCCATGGACAGTACAGACAAGCAGTGCAAAAGGCATAGACTAC
GATAAGCTCATTGTTCGGTTTGGAAGTAGTAAAATTGACAAAGAGCTAATAAACCGAATA
GAGAGAGCCACCGGCCAAAGACCACACCACTTCCTGCGCAGAGGCATCTTCTTCTCACAC
AGAGATATGAATCAGGTTCTTGATGCCTATGAAAATAAGAAGCCATTTTATCTGTACACG
GGCCGGGGCCCCTCTTCTGAAGCAATGCATGTAGGTCACCTCATTCCATTTATTTTCACA
AAGTGGCTCCAGGATGTATTTAACGTGCCCTTGGTGATCCAGATGACGGATGACGAGAAG
TATCTGTGGAAGGACCTGACCCTGGACCAGGCCTATAGCTATGCTGTGGAGAATGCCAAG
GACATCATCGCCTGTGGCTTTGACATCAACAAGACTTTCATATTCTCTGACCTGGACTAC
ATGGGGATGAGCTCAGGTTTCTACAAAAATGTGGTGAAGATTCAAAAGCATGTTACCTTC
AACCAAGTGAAAGGCATTTTCGGCTTCACTGACAGCGACTGCATTGGGAAGATCAGTTTT
CCTGCCATCCAGGCTGCTCCCTCCTTCAGCAACTCATTCCCACAGATCTTCCGAGACAGG
ACGGATATCCAGTGCCTTATCCCATGTGCCATTGACCAGGATCCTTACTTTAGAATGACA
AGGGACGTCGCCCCCAGGATCGGCTATCCTAAACCAGCCCTGTTGCACTCCACCTTCTTC
CCAGCCCTGCAGGGCGCCCAGACCAAAATGAGTGCCAGCGACCCCAACTCCTCCATCTTC
CTCACCGACACGGCCAAGCAGATCAAAACCAAGGTCAATAAGCATGCGTTTTCTGGAGGG
AGAGACACCATCGAGGAGCACAGGCAGTTTGGGGGCAACTGTGATGTGGACGTGTCTTTC
ATGTACCTGACCTTCTTCCTCGAGGACGACGACAAGCTCGAGCAGATCAGGAAGGATTAC
ACCAGCGGAGCCATGCTCACCGGTGAGCTCAAGAAGGCACTCATAGAGGTTCTGCAGCCC
TTGATCGCAGAGCACCAGGCCCGGCGCAAGGAGGTCACGGATGAGATAGTGAAAGAGTTC
ATGACTCCCCGGAAGCTGTCCTTCGACTTTCAGTAG

# Metabolic_Enzyme_20_GenBank_ID_Gene:
M77804

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_20_Locus:
14q32.31

# Metabolic_Enzyme_20_SNPs:
rs9453; rs2234529; rs941928; rs8012938; rs8022027; rs2400898; rs2400899; rs941927; rs4905956; rs941929; rs941930; rs941931; rs3994912; rs6575775; rs3783346; rs10149239; rs2301240; rs3783347; rs12888855; rs7150701; rs4905957; rs10149438; rs1887198; rs10438233; rs11622361; rs941923; rs1009812; rs9324020; rs2146106; rs2146107; rs7154151; rs11160582; rs10438234; rs2234532; rs10438232; rs1373; rs10142340; rs4905953; rs2234528; rs4905954; rs1570305; rs1983770; rs4900463; rs7144866; rs10141823; rs732625; rs11624738; rs9671761; rs7156157; rs8009897; rs8009435; rs10141847; rs11620717; rs8010851; rs10873516; rs12882639; rs4905952; rs8008560; rs11626703; rs11624974; rs2234523; rs8009578; rs8009443; rs7155068; rs11626882; rs2234530; rs4905951; rs2234533; rs10142580; rs7154999; rs2234525; rs10141925; rs732626; rs11627197; rs11629422; rs7157522; rs3783345; rs2234524; rs11629457; rs11623879; rs8022658; rs8009765; rs11160581; rs3742384; rs8012062; rs6575773; rs3742383; rs12887559; rs2234520; rs2234521; rs2234522; rs11541753; rs1803791; rs11541754; rs3825556; rs34312584; rs34511223; rs2247044; rs34255137; rs34903259; rs2400915; rs12887392; rs2400906; rs2400916; rs1051002; rs1051043; rs12888583; rs2400905; rs34428908; rs2400904; rs6575774; rs13885; rs3838956; rs2400913; rs1131344; rs35551916; rs33915530; rs8018305; rs2246904; rs2400914; rs7906; rs1131345; rs2400902; rs2400911; rs2400918; rs2400909; rs5810994; rs1051022; rs11271487; rs2478493; rs3809407; rs8021207; rs1051051; rs2400917; rs2400912; rs10612736; rs2400903; rs2478492; rs35916618; rs2246905; rs34107388; rs35100722; rs2400907; rs2400900; rs2400910; rs34966278; rs2400908; rs2400901; rs34345611; rs12887608; rs34304748; rs3783341; rs35102588; rs12896648; rs34231621; rs11279498; rs28633946; rs12882218; rs28651775; rs11626328; rs35384251; rs35863763; rs12880435; rs2234526; rs12892068; rs3842315; rs12880834; rs3783342; rs10636945; rs34070753; rs12896107; rs5810992; rs8004957; rs34657918; rs28708874; rs35136309; rs10593205; rs12888911; rs34115089; rs35387609; rs2234531; rs11383055; rs8020597; rs4520782; rs36210845; rs8004757; rs35594168; rs12880110; rs34489833; rs11160583; rs11624811; rs12882363; rs2281893; rs12880803; rs7142222; rs35725702; rs33934327; rs7141631; rs8020087; rs2400879; rs9707505; rs12880761; rs33939310; rs3783343; rs2234527; rs4900461; rs12892489; rs34040257; rs10148928; rs10619515; rs35202616; rs12881475; rs12887585; rs11276770; rs3783344; rs34113960; rs35520638; rs33952550; rs11394611; rs34924236; rs35032026; rs34256537; rs10144242; rs10147903; rs11160584; rs11622502; rs12882934; rs12897338; rs12897688; rs17554326; rs1951519; rs1957453; rs2146104; rs2146105; rs2181170; rs2234517; rs2234518; rs2234519; rs2273800; rs2273801; rs2273802; rs2273803; rs2273804; rs2475486; rs3117689; rs34007610; rs34184867; rs34205276; rs34277171; rs34331240; rs35007880; rs35097172; rs35966201; rs36056565; rs3736951; rs3736952; rs3742380; rs3742381; rs3742382; rs3742387; rs3764786; rs4905950; rs7143025; rs7147511; rs7155877; rs724392; rs732898; rs8007184; rs8015259; rs9324019; rs941926; rs9972137

# Metabolic_Enzyme_20_General_References:
1761529; 1763065; 1765274; 1537332; 8724762; 7685728; 1286667; 1373391

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
5847

# Metabolic_Enzyme_21_Name:
High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

# Metabolic_Enzyme_21_Synonyms:
Not Available

# Metabolic_Enzyme_21_Gene_Name:
PDE8A

# Metabolic_Enzyme_21_Protein_Sequence:
>Highaffinity cAMPspecific and IBMXinsensitive 3',5'cyclic phosphodiesterase 8
AMGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGS
GKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLAC
FLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAG
FTRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQY
ANPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDN
IQQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGS
LDVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVL
EILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPI
SLDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLR
SWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVD
HPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQ
GIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKR
MLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQI
SFIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE

# Metabolic_Enzyme_21_Number_of_Residues:
829

# Metabolic_Enzyme_21_Molecular_Weight:
93305

# Metabolic_Enzyme_21_Theoretical_pI:
6.03

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  two-component response regulator activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein histidine kinase activity
Function:  two-component sensor molecule activity
Function:  signal transducer activity
Function:  catalytic activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
Process:  two-component signal transduction system (phosphorelay)
Process:  two-component signal transduction system (phosphorelay)
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Signal transduction mechanisms 

# Metabolic_Enzyme_21_Specific_Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase, which has a high affinity for cAMP, may be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development

# Metabolic_Enzyme_21_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_21_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF00989:PAS;
PF08629:PDE8;
PF00233:PDEase_I;
PF00072:Response_reg

# Metabolic_Enzyme_21_Signals:
None

# Metabolic_Enzyme_21_Transmembrane_Regions:
None

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_21_GenBank_ID_Protein:
16417190

# Metabolic_Enzyme_21_SwissProt_ID:
PDE8A_HUMAN (O60658)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
PDE8A

# Metabolic_Enzyme_21_Geneatlas_id:
PDE8A

# Metabolic_Enzyme_21_hgnc_id:
HGNC:8793

# Metabolic_Enzyme_21_PDB_ID:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_21_Gene_Sequence:
>2490 bp
ATGGGCTGTGCCCCGAGCATCCACATTTCCGAGCGCCTGGTGGCCGAGGACGCGCCTAGC
CCCGCGGCACCGCCGCTGTCGTCCGGCGGGCCGCGCCTCCCGCAGGGCCAGAAGACGGCC
GCCTTGCCCCGGACCCGCGGCGCCGGCCTCTTGGAGTCGGAGCTTCGCGACGGCAGCGGC
AAGAAGGTAGCAGTAGCTGATGTGCAGTTTGGCCCCATGAGATTTCATCAAGATCAACTT
CAGGTACTTTTAGTGTTTACCAAAGAAGATAACCAATGTAATGGATTCTGCAGGGCATGT
GAAAAAGCAGGGTTTAAGTGTACAGTTACCAAGGAGGCTCAGGCTGTCCTTGCCTGTTTC
CTGGACAAACATCATGACATTATCATCATAGACCACAGAAATCCTCGACAGCTGGATGCA
GAGGCACTGTGCAGGTCTATCAGATCATCAAAACTCTCAGAAAACACAGTTATTGTTGGT
GTAGTACGCAGGGTGGATAGAGAAGAGTTGTCCGTAATGCCTTTCATTTCTGCTGGATTT
ACAAGGAGGTATGTAGAAAACCCCAACATCATGGCCTGCTACAATGAACTGCTCCAGCTG
GAGTTTGGAGAGGTGCGATCACAACTGAAACTCAGGGCTTGTAACTCAGTATTCACTGCA
TTAGAAAACAGTGAAGATGCAATTGAAATTACAAGCGAAGACCGTTTTATACAGTATGCA
AATCCTGCATTTGAAACAACAATGGGCTATCAGTCAGGTGAATTAATAGGGAAGGAGTTA
GGAGAAGTGCCTATAAATGAAAAAAAGGCTGACTTGCTCGATACTATAAATTCATGCATC
AGGATAGGCAAGGAGTGGCAAGGAATTTACTATGCAAAAAAGAAAAACGGAGATAATATA
CAACAAAATGTGAAGATAATACCTGTCATTGGACAGGGAGGAAAAATTAGACACTATGTG
TCCATTATCAGAGTGTGCAATGGCAACAATAAGGCTGAGAAAATATCCGAATGTGTTCAG
TCTGACACTCATACAGATAATCAGACAGGCAAACATAAAGACAGGAGAAAAGGCTCACTA
GACGTCAAAGCTGTTGCCTCCCGTGCAACTGAAGTTTCCAGCCAGAGACGACACTCTTCC
ATGGCCCGGATACATTCCATGACAATTGAGGCGCCCATCACCAAGGTAATCAATATTATC
AATGCTGCCCAGGAAAGTAGTCCCATGCCTGTGACAGAAGCCCTAGACCGTGTGCTGGAA
ATTCTAAGAACCACTGAGTTATATTCACCACAGTTTGGTGCTAAAGATGATGATCCCCAT
GCCAATGACCTTGTTGGGGGCTTAATGTCTGATGGTTTGCGAAGACTATCAGGGAATGAA
TATGTTCTTTCAACAAAAAACACTCAAATGGTTTCAAGCAATATAATCACTCCCATCTCC
CTTGATGATGTCCCACCACGGATAGCTCGGGCCATGGAAAATGAGGAATACTGGGACTTT
GATATTTTTGAACTGGAGGCTGCCACCCACAATAGGCCTTTGATTTATCTTGGTCTCAAA
ATGTTTGCTCGCTTTGGAATCTGTGAATTCTTACACTGCTCCGAGTCAACGCTAAGATCA
TGGTTACAAATTATCGAAGCCAATTATCATTCCTCCAATCCCTACCACAATTCTACACAT
TCTGCTGATGTGCTTCATGCCACTGCCTATTTTCTCTCCAAGGAGAGGATAAAGGAAACT
TTAGATCCAATTGATGAGGTCGCTGCACTCATCGCAGCCACCATTCATGATGTGGATCAC
CCTGGGAGAACCAACTCCTTCCTGTGTAATGCTGGAAGTGAGCTGGCCATTTTGTACAAT
GACACTGCTGTGCTGGAGAGCCACCATGCGGCCTTGGCCTTCCAGCTGACCACTGGAGAT
GATAAATGCAATATATTTAAAAACATGGAGAGGAATGATTATCGGACACTGCGCCAGGGG
ATTATCGACATGGTCTTAGCCACAGAAATGACAAAGCACTTTGAGCATGTCAACAAATTT
GTCAACAGCATCAACAAACCCTTGGCAACACTAGAAGAAAATGGGGAAACTGATAAAAAC
CAGGAAGTGATAAACACTATGCTTAGGACTCCAGAGAACCGGACCCTAATCAAACGAATG
CTGATTAAATGTGCTGATGTGTCCAATCCCTGCCGACCCCTGCAGTACTGCATCGAGTGG
GCTGCACGCATTTCGGAAGAATATTTTTCTCAGACTGATGAAGAGAAGCAGCAGGGCTTA
CCTGTGGTGATGCCAGTGTTTGACAGAAATACCTGCAGCATCCCCAAATCCCAAATCTCT
TTCATTGATTACTTCATCACAGACATGTTTGATGCTTGGGATGCCTTTGTAGACCTGCCT
GATTTAATGCAGCATCTTGACAACAACTTTAAATACTGGAAAGGACTGGACGAAATGAAG
CTGCGGAACCTCCGACCACCTCCTGAATAG

# Metabolic_Enzyme_21_GenBank_ID_Gene:
AF388183

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_21_Locus:
15q25.3

# Metabolic_Enzyme_21_SNPs:
rs16974908; rs289392; rs2304422; rs289412; rs289389; rs734495; rs1973516; rs1014543; rs289374; rs289417; rs2342974; rs1868921; rs930716; rs289400; rs289390; rs12904386; rs289383; rs289393; rs12904890; rs12437935; rs289414; rs289411; rs6496586; rs3816106; rs289405; rs7402176; rs2290273; rs289387; rs7402932; rs289410; rs8026543; rs379799; rs12903975; rs4843019; rs289386; rs3816104; rs11073916; rs3816103; rs289418; rs11856330; rs2304416; rs4842864; rs7174722; rs2304417; rs11073917; rs8032301; rs289399; rs7182533; rs971804; rs185972; rs418676; rs11073939; rs8038149; rs2304420; rs7402770; rs9920027; rs2304419; rs409211; rs7403474; rs2122858; rs289416; rs7163965; rs208966; rs7175477; rs2304418; rs744422; rs10852130; rs12440719; rs11631548; rs12912134; rs190840; rs11632658; rs12232314; rs12102045; rs10520586; rs289419; rs11854452; rs2923731; rs1011436; rs2015233; rs2304421; rs289381; rs289388; rs12904238; rs7182328; rs289401; rs12438909; rs17540307; rs2938354; rs3816105; rs289380; rs289406; rs12902942; rs17611396; rs4842865; rs16974823; rs17541051; rs1011437; rs289402; rs17610201; rs289396; rs289375; rs11631171; rs2304415; rs289403; rs1969101; rs17611171; rs17612860; rs11856097; rs8032954; rs12441196; rs7174762; rs11632899; rs1023844; rs16974676; rs16974785; rs12592539; rs16974197; rs12910668; rs2174218; rs12909971; rs7402179; rs289404; rs12913859; rs4843014; rs289391; rs380185; rs289373; rs289413; rs289409; rs289379; rs4842863; rs16974804; rs12910060; rs4843015; rs11634975; rs11858363; rs12905036; rs12904615; rs16974868; rs12903145; rs289378; rs289407; rs16974819; rs7182132; rs4980356; rs17841204; rs16974764; rs16974757; rs8039136; rs17611290; rs7170598; rs12909111; rs12900736; rs12438541; rs377369; rs16974726; rs395573; rs11634877; rs12900012; rs9302348; rs16974846; rs13380056; rs7359256; rs12904766; rs11637237; rs4980340; rs289376; rs289382; rs17610265; rs4842866; rs16974870; rs11632175; rs11856381; rs12899693; rs7403468; rs16974769; rs12904410; rs12906544; rs289420; rs35000527; rs12908535; rs12908400; rs11629962; rs17611075; rs167036; rs1532776; rs8029977; rs12912860; rs12911330; rs8039116; rs10083650; rs2599365; rs4843018; rs16974820; rs8028550; rs12908252; rs2599364; rs188296; rs8040352; rs7402299; rs11852878; rs8025202; rs12916129; rs16974844; rs16974793; rs16974867; rs8029936; rs289415; rs7178852; rs9796658; rs11629963; rs289397; rs8035204; rs16974732; rs7178157; rs17540501; rs16974775; rs12440263; rs12324252; rs16974842; rs16974673; rs12909130; rs439307; rs289398; rs8023667; rs8041380; rs11073905; rs11637512; rs4296226; rs7403597; rs11629967; rs3850985; rs11854185; rs16974759; rs439313; rs16974194; rs12591070; rs10852131; rs11073915; rs12439284; rs16974777; rs11630697; rs7183199; rs16974791; rs16974827; rs11631184; rs11073955; rs6496733; rs994989; rs11073962; rs8041624; rs7167692; rs11073952; rs4843020; rs4842868; rs16974899; rs13379959; rs12592211; rs1606119; rs7171410; rs907260; rs3743157; rs6496728; rs3862411; rs17541572; rs10520585; rs11852268; rs11073951; rs12899508; rs7177110; rs16974896; rs16974907; rs12324715; rs10152707; rs16974898; rs12594377; rs16974913; rs4842867; rs12324638; rs12904058; rs11633076; rs12914674; rs12324243; rs12148170; rs16974889; rs11638610; rs2063441; rs11540803; rs17855018; rs35666574; rs35134026; rs28517708; rs34477344; rs289377; rs34139398; rs3835084; rs12905238; rs36160047; rs11633746; rs35038078; rs35476219; rs34096140; rs28583919; rs36146722; rs16974849; rs28599738; rs11447909; rs34187163; rs35529308; rs10683452; rs34026921; rs10686479; rs28393234; rs12912097; rs3042715; rs35843593; rs35816571; rs7496602; rs35835700; rs34212320; rs34978449; rs10596049; rs12593868; rs12903901; rs5814181; rs35668291; rs4980341; rs35902872; rs34345801; rs35287208; rs12443441; rs36226498; rs182326; rs28432948; rs4038084; rs35024665; rs28626509; rs28674753; rs4038603; rs10714340; rs35613655; rs12899359; rs16974740; rs12899190; rs9920206; rs12904958; rs34715649; rs12916821; rs28703945; rs34741081; rs12908865; rs16974874; rs7163704; rs2654915; rs3077007; rs16974881; rs34743976; rs13379950; rs35119272; rs28481453; rs10551825; rs28871662; rs35955528; rs16974781; rs35060961; rs35991556; rs35159041; rs34039117; rs28522595; rs35051517; rs34571125; rs12595013; rs34431228; rs28422178; rs35472864; rs2599366; rs35885781; rs34623053; rs13379744; rs289394; rs35224089; rs10583862; rs12910192; rs11279216; rs9920260; rs35985534; rs28460774; rs34072250; rs12910966; rs11300943; rs2134701; rs12915883; rs28821898; rs16974754; rs28718705; rs8040568; rs35204319; rs35155549; rs16974851; rs3947198; rs34868660; rs12911951; rs35362357; rs11408402; rs12905230; rs8031544; rs35835007; rs35886421; rs12593499; rs289395; rs16974834; rs5814184; rs35127646; rs34005057; rs7181707; rs35924887; rs11302685; rs12913418; rs34900320; rs11315378; rs12911275; rs11335223; rs34941017; rs36184157; rs28624247; rs12324120; rs34578731; rs35013304; rs35704021; rs34919315; rs35100589; rs28451934; rs12910937; rs28515053; rs35850143; rs35495694; rs35661908; rs34450665; rs28887294; rs35165347; rs3029849; rs3076299; rs12912264; rs28660426; rs36210492; rs1466166; rs28408242; rs4843016; rs3042743; rs188295; rs35845738; rs35782842; rs16974722; rs28401313; rs35332444; rs8033951; rs28635537; rs289408; rs4461049; rs34347191; rs3752716; rs7167955; rs34224590; rs28380121; rs2134700; rs28836780; rs34928221; rs11444714; rs13379486; rs289385; rs28567794; rs12913075; rs34585903; rs35932936; rs13380094; rs28435132; rs5814182; rs35818984; rs28438405; rs3042699; rs34054841; rs7496012; rs3042742; rs4843017; rs34703175; rs34493704; rs185973; rs5814185; rs11300141; rs28406814; rs11439217; rs16974713; rs33996207; rs34731527; rs34127115; rs28369034; rs28765192; rs34366010; rs12909357; rs28669942; rs35249102; rs35710429; rs12913985; rs10656480; rs28614128; rs3947199; rs28767827; rs34363361; rs3076297; rs5814183; rs16974847; rs289384; rs35525107; rs11286200; rs28584329; rs28878517; rs35570249; rs34684329; rs34469124; rs35150470; rs35148427; rs34262848; rs2060785; rs35187382; rs11362736; rs905600; rs28523473; rs12906040; rs11308498; rs12904056; rs34105012; rs2015030; rs4843013; rs11438322; rs35349728; rs34790691; rs2005228; rs28715864; rs8032061; rs28483160; rs35094470; rs6496597; rs34376876; rs35007697; rs34486009; rs16974680; rs28599761; rs35166229; rs10525874; rs34787669; rs34946321; rs12914463; rs34343213; rs35264353; rs3214641; rs35094035; rs35490949; rs2060784; rs35548176; rs4980357; rs12917019; rs28540038; rs35668265; rs28679569; rs3743158; rs10152517; rs6145662; rs35865189; rs34076898; rs28762802; rs35054546; rs16974903; rs1272789; rs16974914; rs34339351; rs35533990; rs35045545; rs28463717; rs1260127; rs28445014; rs12324052; rs34889576; rs35457936; rs34655030; rs16974894; rs8032913; rs34002838; rs35114584; rs36097427; rs34969758; rs1109065; rs1109066; rs11635139; rs12439802; rs12899275; rs12900078; rs35966827; rs7175160; rs7177863; rs7178415; rs8035516; rs8037886; rs896364

# Metabolic_Enzyme_21_General_References:
11738832; 9618252

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
5848

# Metabolic_Enzyme_22_Name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

# Metabolic_Enzyme_22_Synonyms:
Cam-PDE 1B; 63 kDa Cam-PDE

# Metabolic_Enzyme_22_Gene_Name:
PDE1B

# Metabolic_Enzyme_22_Protein_Sequence:
>Calcium/calmodulindependent 3',5'cyclic nucleotide phosphodiesterase 1
BMELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKN
LEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEK
PKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHA
LRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFL
LRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISS
VFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKP
KALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQ
SQIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVV
SFRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD

# Metabolic_Enzyme_22_Number_of_Residues:
536

# Metabolic_Enzyme_22_Molecular_Weight:
61380

# Metabolic_Enzyme_22_Theoretical_pI:
5.22

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Not Available

# Metabolic_Enzyme_22_Specific_Function:
Has a preference for cGMP as a substrate

# Metabolic_Enzyme_22_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_22_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF00233:PDEase_I;
PF08499:PDEase_I_N

# Metabolic_Enzyme_22_Signals:
None

# Metabolic_Enzyme_22_Transmembrane_Regions:
None

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_22_GenBank_ID_Protein:
1621592

# Metabolic_Enzyme_22_SwissProt_ID:
PDE1B_HUMAN (Q01064)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
PDE1B

# Metabolic_Enzyme_22_Geneatlas_id:
PDE1B

# Metabolic_Enzyme_22_hgnc_id:
HGNC:8775

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_22_Gene_Sequence:
>1611 bp
ATGGAGCTGTCCCCCCGCAGTCCTCCGGAGATGCTGGAGGAGTCGGATTGCCCGTCACCC
CTGGAGCTGAAGTCAGCCCCCAGCAAGAAGATGTGGATTAAGCTTCGGTCTCTGCTGCGC
TACATGGTGAAGCAGTTGGAGAATGGGGAGATAAACATTGAGGAGCTGAAGAAAAATCTG
GAGTACACAGCTTCTCTGCTGGAAGCCGTCTACATAGATGAGACACGGCAAATCTTGGAC
ACGGAGGACGAGCTGCAGGAGCTGCGGTCAGATGCCGTGCCTTCGGAGGTGCGGGACTGG
CTGGCCTCCACCTTCACCCAGCAGGCCCGGGCCAAAGGCCGCCGAGCAGAGGAGAAGCCC
AAGTTCCGAAGCATTGTGCACGCTGTGCAGGCTGGGATCTTCGTGGAACGGATGTTCCGG
AGAACATACACCTCTGTGGGCCCCACTTACTCTACTGCGGTTCTCAACTGTCTCAAGAAC
CTGGATCTCTGGTGCTTTGATGTCTTTTCCTTGAACCAGGCAGCAGATGACCATGCCCTG
AGGACCATTGTTTTTGAGTTGCTGACTCGGCATAACCTCATCAGCCGCTTCAAGATTCCC
ACTGTGTTTTTGATGAGTTTCCTGGATGCCTTGGAGACAGGCTATGGGAAGTACAAGAAT
CCTTACCACAACCAGATCCACGCAGCCGATGTTACCCAGACAGTCCATTGCTTCTTGCTC
CGCACAGGGATGGTGCACTGCCTGTCGGAGATTGAGCTCCTGGCCATCATCTTTGCTGCA
GCTATCCATGATTATGAGCACACGGGCACTACCAACAGCTTCCACATCCAGACCAAGTCA
GAATGTGCCATCGTGTACAATGATCGTTCAGTGCTGGAGAATCACCACATCAGCTCTGTT
TTCCGATTGATGCAGGATGATGAGATGAACATTTTCATCAACCTCACCAAGGATGAGTTT
GTAGAACTCCGAGCCCTGGTCATTGAGATGGTGTTGGCCACAGACATGTCCTGCCATTTC
CAGCAAGTGAAGACCATGAAGACAGCCTTGCAACAGCTGGAGAGGATTGACAAGCCCAAG
GCCCTGTCTCTACTGCTCCATGCTGCTGACATCAGCCACCCAACCAAGCAGTGGTTGGTC
CACAGCCGTTGGACCAAGGCCCTCATGGAGGAATTCTTCCGTCAGGGTGACAAGGAGGCA
GAGTTGGGCCTGCCCTTTTCTCCACTCTGTGACCGCACTTCCACTCTAGTGGCACAGTCT
CAGATAGGGTTCATCGACTTCATTGTGGAGCCCACATTCTCTGTGCTGACTGACGTGGCA
GAGAAGAGTGTTCAGCCCCTGGCGGATGAGGACTCCAAGTCTAAAAACCAGCCCAGCTTT
CAGTGGCGCCAGCCCTCTCTGGATGTGGAAGTGGGAGACCCCAACCCTGATGTGGTCAGC
TTTCGTTCCACCTGGGTCAAGCGCATTCAGGAGAACAAGCAGAAATGGAAGGAACGGGCA
GCAAGTGGCATCACCAACCAGATGTCCATTGACGAGCTGTCCCCCTGTGAAGAAGAGGCC
CCCCCATCCCCTGCCGAAGATGAACACAACCAGAATGGGAATCTGGATTAG

# Metabolic_Enzyme_22_GenBank_ID_Gene:
U56976

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_22_Locus:
12q13

# Metabolic_Enzyme_22_SNPs:
rs1249950; rs884510; rs1249951; rs1022232; rs3782403; rs1976823; rs1153138; rs11170969; rs1874308; rs7954532; rs7308435; rs1874309; rs3782404; rs1153137; rs1249949; rs4759090; rs3782411; rs11170973; rs11170974; rs2280426; rs3782410; rs11170976; rs10747699; rs1874305; rs1619029; rs1874307; rs1826728; rs1795814; rs3782405; rs10876566; rs1826729; rs7300897; rs12315671; rs4759091; rs1153136; rs1144995; rs7297522; rs9668037; rs7953703; rs10161382; rs4759092; rs12580297; rs12423459; rs3782409; rs3741670; rs7134688; rs3741671; rs7980139; rs11615709; rs12811737; rs12811532; rs12812036; rs2887906; rs35108378; rs11170978; rs34320482; rs5798310; rs2669404; rs4016630; rs35584396; rs11384809; rs1716335; rs12817930; rs35953387; rs35083639; rs34945831; rs4016629; rs1249684; rs10574598; rs36106145; rs2669406; rs34139185; rs2643610; rs34082972; rs5798309; rs1153139; rs11170971; rs34681049; rs1874306; rs34490177; rs5798308; rs34981158; rs3953265; rs4016627; rs35412225; rs10537588; rs3036634; rs34955742; rs1552957; rs1623252; rs35999388; rs12817736; rs11170972; rs12811907; rs3953266; rs3953264; rs4016628; rs3825194; rs35888172; rs35726390; rs3782407; rs10747698; rs12315672; rs35023953; rs1795817; rs3782408; rs35120300; rs1249948; rs34237967; rs3837464; rs35818150; rs35203189; rs7960002; rs35068189; rs34815974; rs35136005; rs12814787; rs12297247; rs3832832; rs11616154; rs10783631; rs10876567; rs11170968; rs11170979; rs11170980; rs11170981; rs1143960; rs1144996; rs1144997; rs1144998; rs1144999; rs1145000; rs1153140; rs1153141; rs11836274; rs1249499; rs1249682; rs1249683; rs1512905; rs1533235; rs1707483; rs2271981; rs2271982; rs2292490; rs2370971; rs3209081; rs34071274; rs34376731; rs35146181; rs3817412; rs3825195; rs7297136; rs7971175; rs8407

# Metabolic_Enzyme_22_General_References:
8855339; 9419816; 1326532

# Metabolic_Enzyme_22_References:
Not Available

# Metabolic_Enzyme_23_ID:
5849

# Metabolic_Enzyme_23_Name:
Long-chain-fatty-acid--CoA ligase 1

# Metabolic_Enzyme_23_Synonyms:
Long-chain acyl-CoA synthetase 1; LACS 1; Palmitoyl-CoA ligase 1; Long-chain fatty acid CoA ligase 2; Long-chain acyl-CoA synthetase 2; LACS 2; Acyl-CoA synthetase 1; ACS1; Palmitoyl-CoA ligase 2

# Metabolic_Enzyme_23_Gene_Name:
ACSL1

# Metabolic_Enzyme_23_Protein_Sequence:
>LongchainfattyacidCoA ligase 1
MQAHELFRYFRMPELVDFRQYVRTLPTNTLMGFGAFAALTTFWYATRPKPLKPPCDLSMQ
SVEVAGSGGARRSALLDSDEPLVYFYDDVTTLYEGFQRGIQVSNNGPCLGSRKPDQPYEW
LSYKQVAELSECIGSALIQKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSMVIVPLYDT
LGNEAITYIVNKAELSLVFVDKPEKAKLLLEGVENKLIPGLKIIVVMDAYGSELVERGQR
CGVEVTSMKAMEDLGRANRRKPKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAF
VKATENTVNPCPDDTLISFLPLAHMFERVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQP
TVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKV
QSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHV
GAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGD
IGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAI
VVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRLGKDSGLKPFEQVKGITLHP
ELFSIDNGLLTPTMKAKRPELRNYFRSQIDDLYSTIKV

# Metabolic_Enzyme_23_Number_of_Residues:
698

# Metabolic_Enzyme_23_Molecular_Weight:
77944

# Metabolic_Enzyme_23_Theoretical_pI:
7.16

# Metabolic_Enzyme_23_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_23_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_23_Specific_Function:
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate

# Metabolic_Enzyme_23_Pathway:
map00071  Fatty acid metabolism

# Metabolic_Enzyme_23_Reaction:
ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_23_Signals:
None

# Metabolic_Enzyme_23_Transmembrane_Regions:
25-45

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 6.2.1.3

# Metabolic_Enzyme_23_GenBank_ID_Protein:
219900

# Metabolic_Enzyme_23_SwissProt_ID:
ACSL1_HUMAN (P33121)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
ACSL1

# Metabolic_Enzyme_23_Geneatlas_id:
ACSL1

# Metabolic_Enzyme_23_hgnc_id:
HGNC:3569

# Metabolic_Enzyme_23_PDB_ID:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type III membrane protein. Peroxisome; peroxisomal membrane; single-pass type III membrane protein (By similarity). Microsome; microsomal membrane; single-pass type III membrane protein (By similarity)

# Metabolic_Enzyme_23_Gene_Sequence:
>2097 bp
ATGCAAGCCCATGAGCTGTTCCGGTATTTTCGAATGCCAGAGCTGGTTGACTTCCGACAG
TACGTGCGTACTCTTCCGACCAACACGCTTATGGGCTTCGGAGCTTTTGCAGCACTCACC
ACCTTCTGGTACGCCACGAGACCCAAACCCCTGAAGCCGCCATGCGACCTCTCCATGCAG
TCAGTGGAAGTGGCGGGTAGTGGTGGTGCACGAAGATCCGCACTACTTGACAGCGACGAG
CCCTTGGTGTATTTCTATGATGATGTCACAACATTATACGAAGGTTTCCAGAGGGGAATA
CAGGTGTCAAATAATGGCCCTTGTTTAGGCTCTCGGAAACCAGACCAACCCTATGAATGG
CTTTCATATAAACAGGTTGCAGAATTGTCGGAGTGCATAGGCTCAGCACTGATCCAGAAG
GGCTTCAAGACTGCCCCAGATCAGTTCATTGGCATCTTTGCTCAAAATAGACCTGAGTGG
GTGATTATTGAACAAGGATGCTTTGCTTATTCGATGGTGATCGTTCCACTTTATGATACC
CTTGGAAATGAAGCCATCACGTACATAGTCAACAAAGCTGAACTCTCTCTGGTTTTTGTT
GACAAGCCAGAGAAGGCCAAACTCTTATTAGAGGGTGTAGAAAATAAGTTAATACCAGGC
CTTAAAATCATAGTTGTCATGGATGCCTACGGCAGTGAACTGGTGGAACGAGGCCAGAGG
TGTGGGGTGGAAGTCACCAGCATGAAGGCGATGGAGGACCTGGGAAGAGCCAACAGACGG
AAGCCCAAGCCTCCAGCACCTGAAGATCTTGCAGTAATTTGTTTCACAAGTGGAACTACA
GGCAACCCCAAAGGAGCAATGGTCACTCACCGAAACATAGTGAGCGATTGTTCAGCTTTT
GTGAAAGCAACAGAGAATACAGTCAATCCTTGCCCAGATGATACTTTGATATCTTTCTTG
CCTCTCGCCCATATGTTTGAGAGAGTTGTAGAGTGTGTAATGCTGTGTCATGGAGCTAAA
ATCGGATTTTTCCAAGGAGATATCAGGCTGCTCATGGATGACCTCAAGGTGCTTCAACCC
ACTGTCTTCCCCGTGGTTCCAAGACTGCTGAACCGGATGTTTGACCGAATTTTCGGACAA
GCAAACACCACGCTGAAGCGATGGCTCTTGGACTTTGCCTCCAAGAGGAAAGAAGCAGAG
CTTCGCAGCGGCATCATCAGAAACAACAGCCTGTGGGACCGGCTGATCTTCCACAAAGTA
CAGTCGAGCCTGGGCGGAAGAGTCCGGCTGATGGTGACAGGAGCCGCCCCGGTGTCTGCC
ACTGTGCTGACGTTCCTCAGAGCAGCCCTGGGCTGTCAGTTTTATGAAGGATACGGACAG
ACAGAGTGCACTGCCGGGTGCTGCCTAACCATGCCTGGAGACTGGACCGCAGGCCATGTT
GGGGCCCCGATGCCGTGCAATTTGATAAAACTTGTTGATGTGGAAGAAATGAATTACATG
GCTGCCGAGGGCGAGGGCGAGGTGTGTGTGAAAGGGCCAAATGTATTTCAGGGCTACTTG
AAGGACCCAGCGAAAACAGCAGAAGCTTTGGACAAAGACGGCTGGTTACACACAGGGGAC
ATTGGAAAATGGTTACCAAATGGCACCTTGAAAATTATCGACCGGAAAAAGCACATATTT
AAGCTGGCACAAGGAGAATACATAGCCCCTGAAAAGATTGAAAATATCTACATGCGAAGT
GAGCCTGTTGCTCAGGTGTTTGTCCACGGAGAAAGCCTGCAGGCATTTCTCATTGCAATT
GTGGTACCAGATGTTGAGACATTATGTTCCTGGGCCCAAAAGAGAGGATTTGAAGGGTCG
TTTGAGGAACTGTGCAGAAATAAGGATGTCAAAAAAGCTATCCTCGAAGATATGGTGAGA
CTTGGGAAGGATTCTGGTCTGAAACCATTTGAACAGGTCAAAGGCATCACATTGCACCCT
GAATTATTTTCTATCGACAATGGCCTTCTGACTCCAACAATGAAGGCGAAAAGGCCAGAG
CTGCGGAACTATTTCAGGTCGCAGATAGATGACCTCTATTCCACTATCAAGGTTTAG

# Metabolic_Enzyme_23_GenBank_ID_Gene:
D10040

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_23_Locus:
4q34-q35

# Metabolic_Enzyme_23_SNPs:
rs1803898; rs11727009; rs2292898; rs34107464; rs8086; rs2292899; rs9997745; rs902177; rs10471180; rs12503643; rs13120078; rs6552828; rs7657313; rs4862424; rs1056896; rs7437957; rs1554336; rs2139178; rs6832247; rs10471181; rs6853210; rs13126272; rs11726327; rs3806795; rs4862425; rs11932648; rs6858297; rs6855716; rs12499544; rs2280297; rs13112568; rs6858762; rs12504478; rs11724755; rs7676928; rs4862413; rs4862423; rs4862412; rs28372689; rs12639729; rs745805; rs7683514; rs4069938; rs11931086; rs7681334; rs7691972; rs6816777; rs1996546; rs3792311; rs4862417; rs7660927; rs3749233; rs4861631; rs2102862; rs4862415; rs7659090; rs7695270; rs4260575; rs4862416; rs11132255; rs12504996; rs1809661; rs6856120; rs1873227; rs12504993; rs4862419; rs3792312; rs12500973; rs4861632; rs11933776; rs3749232; rs7659849; rs735949; rs7680850; rs6552822; rs2046814; rs7695530; rs10024294; rs10022018; rs7674704; rs4862414; rs7654302; rs7673894; rs7679499; rs3762647; rs12508858; rs7669535; rs10022124; rs3792316; rs7680011; rs10034312; rs7679890; rs7658194; rs6835270; rs7657787; rs7680088; rs7660128; rs12500940; rs4862418; rs12374289; rs7674420; rs11942616; rs7656414; rs12650102; rs3792313; rs7654285; rs4862420; rs7661585; rs10155154; rs7653899; rs1532126; rs12648552; rs13105565; rs11724266; rs1873226; rs7683525; rs7678719; rs11931782; rs6552823; rs6854220; rs4862421; rs1968957; rs6833829; rs6856693; rs6857027; rs10034931; rs12644905; rs9686055; rs1809663; rs35300241; rs41278585; rs11550466; rs7691497; rs34405073; rs10010777; rs11132256; rs28728235; rs35762679; rs10538881; rs28701695; rs13114314; rs13148384; rs35019674; rs10471182; rs11940804; rs3208919; rs34348426; rs35492164; rs6831456; rs10003568; rs28562837; rs9884883; rs1212632; rs10011975; rs11430387; rs13124672; rs6845030; rs35340636; rs34859453; rs13148929; rs1803899; rs7668458; rs6845017; rs34777946; rs9993625; rs34202162; rs12510622; rs28535270; rs36106681; rs35357283; rs13149718; rs10009339; rs1803900; rs6817429; rs13126874; rs34065103; rs34391801; rs939040; rs902172; rs5864900; rs41278587; rs11309893; rs35591478; rs28454355; rs34632049; rs35626120; rs34359988; rs11277994; rs2139180; rs7677878; rs35061702; rs2139179; rs10571387; rs34639885; rs28641704; rs35819308; rs34735694; rs34635480; rs34197776; rs35213333; rs9331559; rs6836024; rs28505088; rs28448828; rs34416324; rs11462454; rs11356929; rs10673308; rs34185049; rs34910932; rs1212963; rs35248610; rs6823198; rs13144160; rs28595757; rs34341754; rs5864899; rs28522296; rs11389928; rs35617684; rs6852479; rs35057394; rs35677827; rs13137179; rs6825554; rs6841747; rs13137387; rs11450168; rs41278583; rs36059531; rs35983670; rs7686479; rs6855063; rs28654407; rs3792314; rs7669004; rs7679708; rs13127985; rs35397890; rs28711309; rs3792315; rs35479277; rs11321925; rs1878873; rs34103839; rs34392146; rs34772558; rs735948; rs35565140; rs10002538; rs35180310; rs879779; rs4862422; rs34311553; rs3840201; rs35698174; rs11323129; rs35994035; rs6828290; rs36077190; rs33938195; rs3840200; rs11412087; rs4577621; rs35487731; rs34084432; rs34360556; rs41278581; rs34032660; rs4861633; rs10536708; rs35746022; rs28582376; rs6857505; rs28526229; rs2020016; rs34309875; rs4861634; rs28709399; rs11325509; rs2090591; rs11457984; rs10005356; rs10018054; rs10021219; rs10021290; rs10027540; rs10033885; rs11732302; rs11934173; rs11934462; rs11935201; rs11936062; rs11938887; rs12512574; rs13127359; rs1387678; rs2171838; rs36080963; rs6552824; rs6827693; rs6854996; rs755534; rs755535; rs755536; rs7675463; rs7675780; rs7676174; rs902179

# Metabolic_Enzyme_23_General_References:
1607358; 8584017; 10548543

# Metabolic_Enzyme_23_References:
Not Available

# Metabolic_Enzyme_24_ID:
5850

# Metabolic_Enzyme_24_Name:
cGMP-inhibited 3',5'-cyclic phosphodiesterase B

# Metabolic_Enzyme_24_Synonyms:
Cyclic GMP-inhibited phosphodiesterase B; CGI-PDE B; CGIPDE1; CGIP1

# Metabolic_Enzyme_24_Gene_Name:
PDE3B

# Metabolic_Enzyme_24_Protein_Sequence:
>cGMPinhibited 3',5'cyclic phosphodiesterase 
BMRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVEL
RPPPASPQQPRRCSPFCRARLSLGALAAFVLALLLGAEPESWAAGAAWLRTLLSVCSHSL
SPLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDG
DAGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGS
LPSALRPLLSGLVGGAGCLLALGLDHFFQIREAPLHPRLSSAAEEKVPVIRPRRRSSCVS
LGETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLSVLNEA
RNMVSDLLTDPSLPPQVISSLRSISSLMGAFSGSCRPKINPLTPFPGFYPCSEIEDPAEK
GDRKLNKGLNRNSLPTPQLRRSSGTSGLLPVEQSSRWDRNNGKRPHQEFGISSQGCYLNG
PFNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPD
TADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCS
GKSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSL
DLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQ
FMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRI
NHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAP
QAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHF
DFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEF
YEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEED
NDTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEE
EKCKADGNKLQVENSSLPQADEIQVIEEADEEE

# Metabolic_Enzyme_24_Number_of_Residues:
1112

# Metabolic_Enzyme_24_Molecular_Weight:
124335

# Metabolic_Enzyme_24_Theoretical_pI:
5.75

# Metabolic_Enzyme_24_GO_Classification:
Not Available

# Metabolic_Enzyme_24_General_Function:
Not Available

# Metabolic_Enzyme_24_Specific_Function:
May play a role in fat metabolism

# Metabolic_Enzyme_24_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_24_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_24_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_24_Signals:
None

# Metabolic_Enzyme_24_Transmembrane_Regions:
88-108
117-137
152-172
192-212
220-240
247-267

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_24_GenBank_ID_Protein:
1145302

# Metabolic_Enzyme_24_SwissProt_ID:
PDE3B_HUMAN (Q13370)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
PDE3B

# Metabolic_Enzyme_24_Geneatlas_id:
PDE3B

# Metabolic_Enzyme_24_hgnc_id:
HGNC:8779

# Metabolic_Enzyme_24_PDB_ID:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential)

# Metabolic_Enzyme_24_Gene_Sequence:
>3339 bp
ATGAGGAGGGACGAGCGAGACGCCAAAGCCATGCGGTCCCTGCAGCCGCCGGATGGGGCC
GGCTCGCCCCCCGAGAGTCTGAGGAACGGCTACGTGAAGAGCTGCGTGAGCCCCTTGCGG
CAGGACCCTCCGCGCGGCTTCTTCTTCCACCTCTGCCGCTTCTGCAACGTGGAGCTGCGG
CCGCCGCCGGCCTCTCCCCAGCAGCCGCGGCGCTGCTCCCCCTTCTGCCGGGCGCGCCTC
TCGCTGGGCGACCTGGCTGCCTTTGTCCTCGCCCTGCTGCTGGGAGCGGAACCCGAGAGC
TGGGCTGCCGGGGCCGCCTGGCTGCGGACGCTGCTGAGCGTGTGTTCGCACAGCTTGAGC
CCCCTCTTCAGCATCGCCTGTGCCTTCTTCTTCCTCACCTGCTTCCTCACCCGGACCAAG
CGGGGACCCGGCCCGGGCCGGAGCTGCGGCTCCTGGTGGCTGCTGGCGCTGCCCGCCTGC
TGTTACCTGGGGGACTTCTTGGTGTGGCAGTGGTGGTCTTGGCCTTGGGGGGATGGCGAC
GCAGGGTCCGCGGCCCCGCACACGCCCCCGGAGGCGGCAGCGGGCAGGTTGCTGCTGGTG
CTGAGCTGCGTAGGGCTGCTGCTGACGCTCGCGCACCCGCTGCGGCTCCGGCACTGCGTT
CTGGTGCTGCTCCTGGCCAGCTTCGTCTGGTGGGTCTCCTTCACCAGCCTCGGGTCGCTG
CCCTCCGCCCTCAGGCCGCTGCTCTCCGGCCTGGTGGGGGGCGCTGGCTGCCTGCTGGCC
CTGGGGTTGGATCACTTCTTTCAAATCAGGGAAGCGCCTCTTCATCCTCGACTGTCCAGT
GCCGCCGAAGAAAAAGTGCCTGTGATCCGACCCCGGAGGAGGTCCAGCTGCGTGTCGTTA
GGAGAAACTGCAGCCAGTTACTATGGCAGTTGCAAAATATTCAGGAGACCGTCGTTGCCT
TGTATTTCCAGAGAACAGATGATTCTTTGGGATTGGGACTTAAAACAATGGTATAAGCCT
CATTATCAAAATTCTGGAGGTGGAAATGGAGTTGATCTTTCAGTGCTAAATGAGGCTCGC
AATATGGTGTCAGATCTTCTGACTGATCCAAGCCTTCCACCACAAGTCATTTCCTCTCTA
CGGAGTATTAGTAGCTTAATGGGTGCTTTCTCAGGTTCCTGTAGGCCAAAGATTAATCCT
CTCACACCATTTCCTGGATTTTACCCCTGTTCTGAAATAGAGGACCCAGCTGAGAAAGGG
GATAGAAAACTTAACAAGGGACTAAATAGGAATAGTTTGCCAACTCCACAGCTGAGGAGA
AGCTCAGGAACTTCAGGATTGCTACCTGTTGAACAGTCTTCAAGGTGGGATCGTAATAAT
GGCAAAAGGCCTCACCAAGAATTTGGCATTTCAAGTCAAGGATGCTATCTAAATGGGCCT
TTTAATTCAAATCTACTGACTATCCCGAAGCAAAGGTCATCTTCTGTATCACTGACTCAC
CATGTAGGTCTCAGAAGAGCTGGTGTTTTGTCCAGTCTGAGTCCTGTGAATTCTTCCAAC
CATGGACCAGTGTCTACTGGCTCTCTAACTAATCGATCACCCATAGAATTTCCTGATACT
GCTGATTTTCTTAATAAGCCAAGCGTTATCTTGCAGAGATCTCTGGGCAATGCACCTAAT
ACTCCAGATTTTTATCAGCAACTTAGAAATTCTGATAGCAATCTGTGTAACAGCTGTGGA
CATCAAATGCTGAAATATGTTTCAACATCTGAATCAGATGGTACAGATTGCTGCAGTGGA
AAATCAGGTGAAGAAGAAAACATTTTCTCGAAAGAATCATTCAAACTTATGGAAACTCAA
CAAGAAGAGGAAACAGAGAAGAAAGACAGCAGAAAATTATTTCAGGAAGGTGATAAGTGG
CTAACAGAAGAGGCACAGAGTGAACAGCAAACAAATATTGAACAGGAAGTATCACTGGAC
CTGATTTTAGTAGAAGAGTATGACTCATTAATAGAAAAGATGAGCAACTGGAATTTTCCA
ATTTTTGAACTTGTAGAAAAGATGGGAGAGAAATCAGGAAGGATTCTCAGTCAGGTTATG
TATACCTTATTTCAAGACACTGGTTTATTGGAAATATTTAAAATTCCCACTCAACAATTT
ATGAACTATTTTCGTGCATTAGAAAATGGCTATCGAGACATTCCTTATCACAATCGTATA
CATGCCACAGATGTGCTACATGCAGTTTGGTATCTGACAACACGGCCAGTTCCTGGCTTA
CAGCAGATCCACAATGGTTGTGGAACAGGAAATGAAACAGATTCTGATGGTAGAATTAAC
CATGGGCGAATTGCTTATATTTCTTCGAAGAGCTGCTCTAATCCTGATGAGAGTTATGGC
TGCCTGTCTTCAAACATTCCTGCATTAGAATTGATGGCTCTATACGTGGCAGCTGCCATG
CATGATTATGATCACCCAGGGAGGACAAATGCATTTCTAGTGGCTACAAATGCCCCTCAG
GCAGTTTTATACAATGACAGATCTGTTCTGGAAAATCATCATGCTGCGTCAGCTTGGAAT
CTATATCTTTCTCGCCCAGAATACAACTTCCTTCTTCATCTTGATCATGTGGAATTCAAG
CGCTTTCGTTTTTTAGTCATTGAAGCAATCCTTGCTACGGATCTTAAAAAGCATTTTGAT
TTTCTCGCAGAATTCAATGCCAAGGCAAATGATGTAAATAGTAATGGCATAGAATGGAGT
AATGAAAATGATCGCCTCTTGGTATGCCAGGTGTGCATCAAACTGGCAGATATAAATGGC
CCAGCAAAAGTTCGAGACTTGCATTTGAAATGGACAGAAGGCATTGTCAATGAATTTTAT
GAGCAGGGAGATGAAGAAGCAAATCTTGGTCTGCCCATCAGTCCATTCATGGATCGTTCT
TCTCCTCAACTAGCAAAACTCCAAGAATCTTTTATCACCCACATAGTGGGTCCCCTGTGT
AACTCCTATGATGCTGCTGGTTTGCTACCAGGTCAGTGGTTAGAAGCAGAAGAGGATAAT
GATACTGAAAGTGGTGATGATGAAGACGGTGAAGAATTAGATACAGAAGATGAAGAAATG
GAAAACAATCTAAATCCAAAACCACCAAGAAGGAAAAGCAGACGGCGAATATTTTGTCAG
CTAATGCACCACCTCACTGAAAACCACAAGATATGGAAGGAAATCGTAGAGGAAGAAGAA
AAATGTAAAGCTGATGGGAATAAACTGCAGGTGGAGAATTCCTCCTTACCTCAAGCAGAT
GAGATTCAGGTAATTGAAGAGGCAGATGAAGAGGAATAG

# Metabolic_Enzyme_24_GenBank_ID_Gene:
U38178

# Metabolic_Enzyme_24_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_24_Locus:
11p15.1

# Metabolic_Enzyme_24_SNPs:
rs4757268; rs1247719; rs1247720; rs2060794; rs6486205; rs10832310; rs10832302; rs7952393; rs1403249; rs10219313; rs2177197; rs1007392; rs2167453; rs1037379; rs7942142; rs7117383; rs10766195; rs10832312; rs10832297; rs7117967; rs4144487; rs7109368; rs2350239; rs1879888; rs7947041; rs10734227; rs10732460; rs4757261; rs10832296; rs1403248; rs1879890; rs10832299; rs7102741; rs10741656; rs4757262; rs16930498; rs11023310; rs11023315; rs10128681; rs11023294; rs731042; rs4344519; rs10832309; rs7113970; rs11821089; rs11493371; rs10832306; rs7116978; rs10832294; rs7103015; rs12577507; rs10430883; rs3206554; rs1879889; rs12419818; rs7119073; rs11826363; rs9971395; rs1496167; rs7125781; rs1451677; rs1037378; rs10741653; rs1451678; rs16930448; rs11023350; rs7939648; rs12416696; rs11827089; rs10832304; rs11023322; rs1542291; rs12283049; rs11023332; rs7944633; rs10766192; rs3740823; rs7938266; rs16930437; rs6486201; rs7118016; rs2349789; rs12295371; rs7483120; rs10160291; rs7108484; rs11023333; rs7102037; rs4757266; rs12788030; rs2122942; rs12575877; rs7119320; rs11600656; rs11600815; rs10832311; rs2349790; rs10832298; rs11023298; rs10741655; rs7109892; rs6486202; rs16930520; rs994953; rs10832291; rs11023314; rs12577302; rs7101755; rs1812422; rs12226716; rs11605452; rs1839834; rs11023307; rs11023293; rs4757264; rs10832303; rs2122941; rs11023338; rs7108485; rs11023312; rs7120890; rs7937511; rs11023341; rs10832308; rs7108996; rs10832290; rs11600054; rs10832307; rs2349792; rs12577984; rs16930516; rs6486203; rs10766189; rs11023301; rs10832289; rs1996845; rs11827484; rs10832293; rs11602976; rs17409116; rs6486200; rs11607383; rs2350240; rs11828362; rs12281928; rs7114131; rs4356261; rs11023295; rs4373971; rs16930500; rs7108085; rs1597689; rs7941356; rs17487995; rs7124234; rs10734226; rs16930417; rs11822044; rs11825595; rs12419657; rs7109324; rs11023366; rs11023299; rs12275997; rs10832301; rs2349793; rs4757269; rs10741654; rs11820798; rs7941282; rs17847308; rs17847305; rs3758762; rs35435795; rs12797647; rs11023300; rs28553464; rs5789854; rs11454337; rs34804824; rs5789848; rs11333119; rs12275731; rs12788403; rs11023317; rs11355203; rs11023367; rs12281621; rs11023323; rs11023306; rs10676187; rs35362268; rs11820859; rs11023348; rs12788556; rs1011649; rs34241017; rs34596529; rs34786278; rs34303741; rs35055334; rs7103459; rs11023331; rs35327317; rs10430881; rs11828911; rs4294593; rs3059191; rs11023352; rs36116790; rs11023364; rs34059683; rs2088266; rs11023343; rs12226160; rs34954349; rs34189385; rs35321904; rs11023360; rs1357333; rs12797253; rs34662834; rs10832292; rs35712723; rs11023327; rs35949086; rs10766193; rs11821380; rs34687016; rs34466563; rs34654813; rs2060795; rs34154564; rs1451675; rs10710184; rs35606970; rs5789853; rs11606533; rs34360743; rs34041254; rs35440758; rs34572489; rs10766194; rs34555721; rs11023356; rs12787596; rs35283294; rs3834439; rs34905422; rs11023325; rs7938369; rs12795812; rs1065539; rs35596025; rs10832295; rs5789851; rs11510168; rs11309629; rs35166452; rs35021133; rs12576750; rs36115886; rs35568417; rs12270174; rs12574319; rs11023320; rs11023349; rs35024500; rs34706114; rs35887203; rs34644033; rs28825106; rs9735337; rs11602179; rs36072943; rs10047458; rs10534250; rs4757263; rs28689801; rs28523396; rs11023344; rs12360598; rs11601586; rs10666771; rs35969978; rs35595332; rs10766190; rs35637093; rs7483046; rs12362671; rs12576508; rs4367976; rs4757267; rs5789846; rs7109801; rs11023351; rs36006283; rs11023359; rs34641133; rs34945945; rs12803117; rs11023330; rs11529568; rs4492851; rs4589330; rs34954991; rs12788363; rs12797543; rs11023368; rs5010969; rs7931505; rs1996844; rs4275651; rs12290200; rs35913217; rs11023296; rs11023326; rs34552938; rs12797650; rs7928396; rs34175247; rs12808918; rs11419989; rs12281550; rs36114974; rs5789852; rs11023361; rs34924724; rs34083172; rs35572071; rs11023319; rs12785496; rs12575421; rs7925742; rs11023329; rs2204135; rs2349791; rs10590358; rs35494855; rs11023321; rs4281505; rs11600046; rs12366054; rs34569843; rs11023335; rs35823303; rs10430882; rs11408185; rs3834440; rs35648670; rs7924479; rs34862859; rs35211975; rs35820244; rs34813284; rs4575307; rs35895679; rs4356262; rs12795858; rs35700152; rs3758763; rs11023354; rs11023324; rs34139819; rs5789847; rs11023365; rs11023345; rs12795794; rs11023313; rs11023309; rs11529569; rs35730548; rs1115248; rs10626907; rs11023358; rs35212472; rs12224911; rs35104590; rs35926137; rs11023308; rs12362090; rs4283008; rs11023337; rs34129246; rs11023342; rs11023357; rs4477466; rs11023311; rs12792463; rs35291929; rs4757265; rs34509621; rs34966272; rs12417206; rs12805859; rs11023347; rs7342234; rs11820820; rs35577691; rs11023362; rs35185862; rs36069287; rs34106565; rs10555077; rs11023316; rs11023305; rs7396747; rs35012534; rs11023318; rs34974264; rs35972023; rs11023353; rs34427806; rs7127312; rs1376692; rs12418776; rs12419521; rs34365112; rs11313201; rs12364493; rs34567179; rs12362122; rs7944149; rs12801860; rs10610728; rs1451676; rs12361595; rs11023292; rs11023336; rs7945265; rs5789850; rs11023363; rs35483173; rs34959387; rs35827559; rs12788203; rs35535425; rs11604119; rs35573904; rs1349535; rs12576554; rs11023346; rs11421967; rs4281506; rs36089212; rs7105853; rs35098776; rs35938275; rs35535548; rs1056584; rs10766188; rs10832288; rs11023291; rs11023302; rs11023304; rs11023370; rs11023371; rs11600307; rs11820826; rs12417788; rs1270458; rs12796659; rs1533852; rs1868997; rs1879891; rs2291781; rs6486207; rs7104901; rs7109770

# Metabolic_Enzyme_24_General_References:
8884271; 8921398

# Metabolic_Enzyme_24_References:
Not Available

# Metabolic_Enzyme_25_ID:
5606

# Metabolic_Enzyme_25_Name:
Glycogen phosphorylase, liver form

# Metabolic_Enzyme_25_Synonyms:
Not Available

# Metabolic_Enzyme_25_Gene_Name:
PYGL

# Metabolic_Enzyme_25_Protein_Sequence:
>Glycogen phosphorylase, liver form
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTV
RDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEA
DDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN
TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL
PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP
KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF
QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQ
ENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV
PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPA
TDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA
ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA
YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE
SNKVNGN

# Metabolic_Enzyme_25_Number_of_Residues:
847

# Metabolic_Enzyme_25_Molecular_Weight:
97150

# Metabolic_Enzyme_25_Theoretical_pI:
7.17

# Metabolic_Enzyme_25_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
Function:  phosphorylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_25_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_25_Specific_Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

# Metabolic_Enzyme_25_Pathway:
map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_25_Reaction:
(1,4-alpha-D-glucosyl)n + phosphate = (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate

# Metabolic_Enzyme_25_Pfam_Domain_Function:
PF00343:Phosphorylase

# Metabolic_Enzyme_25_Signals:
None

# Metabolic_Enzyme_25_Transmembrane_Regions:
None

# Metabolic_Enzyme_25_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_25_EC_Link:
EC 2.4.1.1

# Metabolic_Enzyme_25_GenBank_ID_Protein:
183353

# Metabolic_Enzyme_25_SwissProt_ID:
PYGL_HUMAN (P06737)

# Metabolic_Enzyme_25_swissprot_Name:
Not Available

# Metabolic_Enzyme_25_Genecard_id:
PYGL

# Metabolic_Enzyme_25_Geneatlas_id:
PYGL

# Metabolic_Enzyme_25_hgnc_id:
HGNC:9725

# Metabolic_Enzyme_25_PDB_ID:
1L7X

# Metabolic_Enzyme_25_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_25_Subcellular_Location:
Not Available

# Metabolic_Enzyme_25_Gene_Sequence:
>2544 bp
ATGGGCGAACCGCTGACAGACCAGGAGAAGCGGCGGCAGATCAGCATCCGCGGCATCGTG
GGCGTGGAGAACGTGGCAGAGCTGAAGAAGAGTTTCAACCGGCACCTGCACTTCACGCTG
GTCAAGGACCGCAACGTGGCCACCACCCGCGACTACTACTTCGCGCTGGCGCACACGGTG
CGGGACCACCTGGTGGGGCGCTGGATCCGCACGCAGCAGCACTACTACGACAAGTGCCCC
AAGAGGGAATATTACCTCTCTCTGGAATTTTACATGGGCCGAACATTACAGAACACCATG
ATCAACCTCGGTCTGCAAAATGCCTGTGATGAGGCCATTTACCAGCTTGGATTGGATATA
GAAGAGTTAGAAGAAATTGAAGAAGATGCTGGACTTGGCAATGGTGGTCTTGGGAGACTT
GCTGCCTGCTTCTTGGATTCCATGGCAACCCTGGGACTTGCAGCCTATGGATACGGCATT
CGGTATGAATATGGGATTTTCAATCAGAAGATCCGAGATGGATGGCAGGTAGAAGAAGCA
GATGATTGGCTCAGATATGGAAACCCTTGGGAGAAGTCCCGCCCAGAATTCATGCTGCCT
GTGCACTTCTATGGAAAAGTAGAACACACCAACACCGGGACCAAGTGGATTGACACTCAA
GTGGTCCTGGCTCTGCCATATGACACCCCCGAGCCCGGCTACATGAATAACACTGTCAAC
ACCATGCGCCTCTGGTCTGCTCGGGCACCAAATGACTTTAACCTCAGAGACTTTAATGTT
GGAGACTACATTCAGGCTGTGCTGGACCGAAACCTGGCCGAGAACATCTCCCGGGTCCTC
TATCCCAATGACAATTTTTTTGAAGGGAAGGAGCTAAGATTGAAGCAGGAATACTTTGTG
GTGGCTGCAACCTTGCAAGATATCATCCGCCGTTTCAAAGCCTCCAAGTTTGGCTCCACC
CGTGGTCAAGGAACTGTGTTTGATGCCTTCCCGGATCAGGTGGCCATCCAGCTGAATGAT
ACTCACCCTCGCATCGCGATCCCTGAGCTGATGAGGATTTTTGTGGATATTGAAAAACTG
CCCTGGTCCAAGGCATGGGAGCTCAACCAGAAGACCTTCGCCTACACCAACCACACAGTG
CTCCCGGAAGCCCTGGAGCGCTGGCCCGTGGACCTGGTGGAGAAGCTGCTCCCTCGACAT
TTGGAAATCATTTATGAGATAAATCAGAAGCATTTAGATAGAATTGTGGCCTTGTTTCCT
AAAGATGTGGACCCTCTGAGAAGGATGTCTCTGATAGAAGAGGAAGGAAGCAAAAGGATC
AACATGGCCCATCTCTGCATTGTCGGTTCCCATGCTGTGAATGGCGTGGCTAAAATCCAC
TCAGACATCGTGAAGACTAAAGTATTCAAGGACTTCAGTGAGCTAGAACCTGACAAGTTT
CAGAATAAAACCAATGGGATCACTCCAAGGCGCTGGCTCCTACTCTGCAACCCAGGACTT
GCAGAGCTCATAGCAGAGAAAATTGGAGAAGACTATGTGAAAGACCTGAGCCAGCTGACG
AAGCTCCACAGCTTCCTGGGTGATGATGTCTTCCTCCGGGAACTCGCCAAGGTGAAGCAG
GAGAATAAGCTGAAGTTTTCTCAGTTCCTGGAGACGGAGTACAAAGTGAAGATCAACCCA
TCCTCCATGTTTGATGTCCAGGTGAAGAGGATACATGAGTACAAGCGACAGCTCTTGAAC
TGTCTGCATGTGATCACGATGTACAACCGCATTAAGAAAGACCCTAAGAAGTTATTCGTG
CCAAGGACAGTTATCATTGGTGGTAAAGCTGCCCCAGGATATCACATGGCCAAAATGATC
ATAAAGCTGATCACTTCAGTGGCAGATGTGGTGAACAATGACCCTATGGTTGGAAGCAAG
TTGAAAGTCATCTTCTTGGAGAACTACAGAGTATCTCTTGCTGAAAAAGTCATTCCAGCC
ACAGATCTGTCAGAGCAGATTTCCACTGCAGGCACCGAAGCCTCGGGGACAGGCAATATG
AAGTTCATGCTAAATGGGGCCCTAACTATCGGGACCATGGATGGGGCCAATGTGGAAATG
GCAGAAGAAGCTGGGGAAGAGAACCTGTTCATCTTTGGCATGAGCATAGATGATGTGGCT
GCTTTGGACAAGAAAGGGTACGAGGCAAAAGAATACTATGAGGCACTTCCAGAGCTGAAG
CTGGTCATTGATCAAATTGACAATGGCTTTTTTTCTCCCAAGCAGCCTGACCTCTTCAAA
GATATCATCAACATGCTATTTTATCATGACAGGTTTAAAGTCTTTGCAGACTACGAAGCC
TATGTCAAGTGTCAAGATAAAGTGAGTCAGCTGTACATGAATCCAAAGGCCTGGAACACA
ATGGTACTCAAAAACATAGCTGCCTCGGGGAAATTCTCCAGTGACCGAACAATTAAAGAA
TATGCCCAAAACATCTGGAACGTGGAACCTTCAGATCTAAAGATTTCTCTATCCAATGAA
TCTAACAAAGTCAATGGAAATTGA

# Metabolic_Enzyme_25_GenBank_ID_Gene:
M14636

# Metabolic_Enzyme_25_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_25_Locus:
14q21-q22

# Metabolic_Enzyme_25_SNPs:
rs946616; rs2228499; rs35831273; rs34313873; rs2275465; rs17123244; rs1042193; rs2027342; rs2277456; rs1959527; rs2356729; rs1890706; rs1953875; rs946618; rs946617; rs1890705; rs883699; rs1890707; rs8004768; rs10143053; rs11157783; rs2275464; rs6572712; rs7160537; rs2075646; rs6572710; rs10132049; rs3825542; rs11852047; rs3783275; rs11846565; rs8021270; rs11846180; rs8022952; rs2027341; rs1953872; rs10149867; rs11851644; rs3783273; rs3825541; rs2356535; rs3783274; rs8004788; rs11851482; rs17123189; rs11851115; rs8014291; rs2275466; rs7142143; rs12432519; rs11845307; rs7149936; rs17123178; rs1953873; rs10138493; rs10140858; rs3818871; rs8005400; rs17123235; rs11844515; rs11850411; rs3783276; rs7154048; rs8019788; rs12436081; rs12717412; rs10146041; rs8003312; rs8003460; rs882860; rs8022363; rs17123173; rs9635167; rs6572711; rs17123125; rs10142003; rs17123232; rs8005931; rs4901066; rs11845548; rs11623430; rs12878997; rs8008832; rs17123223; rs8006455; rs8019957; rs17123216; rs17123180; rs8020787; rs17123242; rs3783277; rs8019817; rs11849348; rs11851406; rs8009460; rs8019779; rs11846533; rs11850468; rs10130689; rs8020100; rs9635221; rs12887698; rs2297890; rs7159436; rs3759524; rs2297891; rs8005560; rs7159221; rs1126549; rs35026927; rs34096980; rs11541446; rs1042210; rs1042195; rs17721570; rs35110875; rs1042191; rs11356035; rs8018727; rs10539449; rs11420723; rs35650221; rs28419360; rs34660650; rs34764341; rs35154208; rs5808582; rs33962723; rs7157107; rs36014565; rs8021856; rs3837582; rs10140029; rs34040095; rs28584430; rs10146475; rs5808583; rs34267914; rs35765728; rs4540982; rs11849168; rs12888774; rs12881770; rs12882746; rs8006359; rs9788547; rs17123214; rs8009028; rs34052455; rs35565564; rs35049468; rs35657235; rs17123129; rs34648049; rs3783278; rs5808581; rs10145332; rs35116945; rs17123212; rs28497027; rs11308384; rs4027576; rs12882737; rs35955629; rs35236069; rs34707370; rs11351672; rs12887874; rs35638781; rs17123170; rs11414268; rs12881559; rs10674203; rs34456437; rs10133328; rs1890701; rs12882740; rs41317304; rs33993827; rs11846857; rs8005878; rs35069435; rs35098001; rs7141901; rs3082637; rs35620941; rs35195741; rs8016466; rs17123239; rs12882739; rs12879826; rs4898677; rs28540603; rs34592047; rs34351109; rs28407049; rs28707425; rs12880288; rs28759343; rs1005689; rs1042266; rs11157780; rs11157781; rs11157782; rs11847031; rs11847533; rs11850729; rs11850781; rs12431674; rs12431737; rs12434792; rs12589201; rs12589665; rs12880129; rs12889552; rs12891106; rs1538615; rs17123097; rs17123103; rs17123116; rs1890700; rs1890704; rs2075643; rs2075644; rs2075645; rs2185303; rs2356730; rs28564871; rs34204001; rs34240348; rs34800262; rs35501326; rs3759519; rs3759520; rs3759521; rs4901064; rs4901065; rs4901067; rs7154732; rs7159068; rs885375

# Metabolic_Enzyme_25_General_References:
2877458; 9536091; 9529348; 3509980; 10980448; 10949035; 12204691

# Metabolic_Enzyme_25_References:
Not Available

# Metabolic_Enzyme_26_ID:
5851

# Metabolic_Enzyme_26_Name:
Ubiquitin-conjugating enzyme E2 G1

# Metabolic_Enzyme_26_Synonyms:
Ubiquitin-protein ligase G1; Ubiquitin carrier protein G1; E217K; UBC7

# Metabolic_Enzyme_26_Gene_Name:
UBE2G1

# Metabolic_Enzyme_26_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 G1
MTELQSALLLRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVFKAHLT
FPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIHTVETI
MISVISMLADPNGDSPANVDAAKEWREDRNGEFKRKVARCVRKSQETAFE

# Metabolic_Enzyme_26_Number_of_Residues:
170

# Metabolic_Enzyme_26_Molecular_Weight:
19509

# Metabolic_Enzyme_26_Theoretical_pI:
4.95

# Metabolic_Enzyme_26_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_26_General_Function:
Not Available

# Metabolic_Enzyme_26_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of muscle-specific proteins

# Metabolic_Enzyme_26_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_26_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_26_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_26_Signals:
None

# Metabolic_Enzyme_26_Transmembrane_Regions:
None

# Metabolic_Enzyme_26_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_26_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_26_GenBank_ID_Protein:
1741957

# Metabolic_Enzyme_26_SwissProt_ID:
UB2G1_HUMAN (P62253)

# Metabolic_Enzyme_26_swissprot_Name:
Not Available

# Metabolic_Enzyme_26_Genecard_id:
UBE2G1

# Metabolic_Enzyme_26_Geneatlas_id:
UBE2G1

# Metabolic_Enzyme_26_hgnc_id:
HGNC:12482

# Metabolic_Enzyme_26_PDB_ID:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_26_Subcellular_Location:
Not Available

# Metabolic_Enzyme_26_Gene_Sequence:
>513 bp
ATGACGGAGCTGCAGTCGGCACTGCTACTGCGAAGACAGCTGGCAGAACTCAACAAAAAT
CCAGTGGAAGGCTTTTCTGCAGGTTTAATAGATGACAATGATCTCTACCGATGGGAAGTC
CTTATTATTGGCCCTCCAGATACACTTTATGAAGGTGGTGTTTTTAAGGCTCATCTTACT
TTCCCAAAAGATTATCCCCTCCGACCTCCTAAAATGAAATTCATTACAGAAATCTGGCAC
CCAAATGTTGATAAAAATGGTGATGTGTGCATTTCTATTCTTCATGAGCCTGGGGAAGAT
AAGTATGGTTATGAAAAGCCAGAGGAACGCTGGCTCCCTATCCACACTGTGGAAACCATC
ATGATTAGTGTCATTTCTATGCTGGCAGACCCTAATGGAGACTCACCTGCTAATGTTGAT
GCTGCGAAAGAATGGAGGGAAGATAGAAATGGAGAATTTAAAAGAAAAGTTGCCCGCTGT
GTAAGAAAAAGCCAAGAGACTGCTTTTGAGTGA

# Metabolic_Enzyme_26_GenBank_ID_Gene:
D78514

# Metabolic_Enzyme_26_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_26_Locus:
1q42|17p13.2

# Metabolic_Enzyme_26_SNPs:
rs733622; rs1045738; rs11868068; rs1437808; rs11654273; rs4790603; rs2013283; rs12600975; rs9893691; rs2013273; rs11078493; rs9913489; rs28362547; rs9912854; rs9906446; rs7216966; rs16953866; rs4790604; rs12150283; rs1866176; rs2325941; rs12950048; rs2325989; rs8074770; rs7218234; rs4508454; rs8065280; rs4790605; rs4790613; rs8068219; rs11870158; rs4322703; rs2006762; rs7221915; rs8078739; rs9913013; rs6502780; rs12453940; rs6502779; rs2325987; rs2053255; rs2325988; rs7216130; rs8072251; rs934785; rs9303185; rs3966810; rs12946119; rs9894596; rs16953890; rs7212235; rs4790191; rs4456561; rs6502778; rs4467138; rs7218432; rs9889739; rs1113856; rs8066855; rs9897057; rs12600470; rs8067579; rs2325939; rs7222362; rs8078117; rs4790189; rs8078831; rs4790611; rs12937759; rs11654774; rs3902168; rs11871841; rs4790614; rs11656664; rs12709337; rs8067977; rs12600527; rs9891845; rs1113857; rs11868498; rs8068080; rs7215376; rs9915202; rs7214808; rs8067816; rs17764251; rs8073862; rs8072296; rs7224388; rs2325979; rs2006757; rs7211833; rs2325942; rs8071716; rs16953893; rs2325986; rs12944289; rs4790609; rs1866175; rs8071520; rs8064474; rs8070435; rs2304585; rs12603692; rs4790606; rs8075310; rs11078497; rs4790192; rs11078494; rs11868844; rs8079112; rs8069251; rs12452478; rs11868577; rs11078498; rs2053258; rs12937318; rs986939; rs8077918; rs9904325; rs1866174; rs8068359; rs8068360; rs8076429; rs9891357; rs17764245; rs8075852; rs8068520; rs7214726; rs8078345; rs4790190; rs8070770; rs7207791; rs12945402; rs11869527; rs893380; rs12601676; rs8065534; rs9890023; rs8064596; rs9989459; rs9989438; rs8065822; rs4790602; rs11433380; rs35977240; rs34762028; rs34472070; rs35306814; rs34739171; rs41408848; rs36095612; rs11552811; rs34829074; rs5818942; rs12150539; rs11554619; rs1045734; rs35144534; rs28692508; rs6145959; rs35110702; rs35514092; rs28665988; rs12938587; rs10593474; rs36062523; rs7221389; rs13200; rs9912524; rs28756069; rs12451452; rs3169614; rs28460112; rs11426758; rs35121541; rs34166093; rs34120182; rs1137718; rs8078322; rs34973529; rs11552810; rs9890897; rs11871948; rs28577048; rs35886530; rs8568; rs33950725; rs5003080; rs4790612; rs9901888; rs35044180; rs34014821; rs5818947; rs35066726; rs34732602; rs28524071; rs36099482; rs9674701; rs9910193; rs9674837; rs5818952; rs2325981; rs11078496; rs8078393; rs10713986; rs35264067; rs8069612; rs35897766; rs41356550; rs7208636; rs28536065; rs5003079; rs35288114; rs35123697; rs9941393; rs8082123; rs35482444; rs9907368; rs11657111; rs8073190; rs11410197; rs5818946; rs35550125; rs9897965; rs9907880; rs35412900; rs5818951; rs4357975; rs34190346; rs34209253; rs7220341; rs35005458; rs8182295; rs2006746; rs2325980; rs34334033; rs11437680; rs8064744; rs893381; rs35006294; rs35048765; rs10669832; rs10536668; rs35669810; rs36076476; rs35867792; rs35618711; rs35860249; rs7219792; rs7224148; rs2325985; rs3859211; rs35466443; rs1806893; rs6145961; rs8073409; rs9904114; rs35112203; rs9900787; rs8075151; rs35774067; rs2325940; rs34344004; rs1017445; rs1814417; rs8075816; rs11312770; rs747018; rs35329682; rs34499321; rs28718128; rs2875769; rs35054040; rs35451246; rs9674759; rs35543042; rs34074223; rs35383082; rs34558166; rs10648352; rs8077526; rs7219610; rs35538704; rs7214818; rs8070832; rs35513053; rs7219326; rs2325984; rs10646759; rs5818944; rs12450394; rs11331976; rs1806894; rs4527054; rs9909517; rs35809414; rs5818953; rs35491296; rs2004167; rs34357475; rs35700313; rs34756703; rs34262221; rs35681890; rs35697454; rs10713987; rs35129977; rs34464833; rs11458832; rs7504037; rs34402771; rs35118148; rs12945770; rs34675132; rs8070343; rs2325983; rs8182323; rs28667146; rs28580153; rs4790608; rs35213299; rs2875767; rs35969540; rs34313850; rs5818943; rs35778646; rs34315189; rs35792021; rs35390166; rs4448984; rs33942951; rs35941094; rs4790607; rs10635540; rs4605199; rs3050966; rs5818948; rs35683129; rs10671865; rs35249889; rs35666067; rs4464134; rs4790601; rs7215309; rs7216134; rs8069769; rs924026; rs9906760

# Metabolic_Enzyme_26_General_References:
8893823; 12665801

# Metabolic_Enzyme_26_References:
Not Available

# Metabolic_Enzyme_27_ID:
5852

# Metabolic_Enzyme_27_Name:
Glutaminyl-tRNA synthetase

# Metabolic_Enzyme_27_Synonyms:
Glutamine--tRNA ligase; GlnRS

# Metabolic_Enzyme_27_Gene_Name:
QARS

# Metabolic_Enzyme_27_Protein_Sequence:
>GlutaminyltRNA synthetase
MAALDSLSLFTSLGLSEQKARETLKNSALSAQLREAATQAQQTLGSTIDKATGILLYGLA
SRLRDTRRLSFLVSYIASKKIHTEPQLSAALEYVRSHPLDPIDTVDFERECGVGVIVTPE
QIEEAVEAAINRHRPQLLVERYHFNMGLLMGEARAVLKWADGKMIKNEVDMQVLHLLGPK
LEADLEKKFKVAKARLEETDRRTAKDVVENGETADQTLSLMEQLRGEALKFHKPGENYKT
PGYVVTPHTMNLLKQHLEITGGQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFL
RFDDTNPEKEEAKFFTAICDMVAWLGYTPYKVTYASDYFDQLYAWAVELIRRGLAYVCHQ
RGEELKGHNTLPSPWRDRPMEESLLLFEAMRKGKFSEGEATLRMKLVMEDGKMDPVAYRV
KYTPHHRTGDKWCIYPTYDYTHCLCDSIEHITHSLCTKEFQARRSSYFWLCNALDVYCPV
QWEYGRLNLHYAVVSKRKILQLVATGAVRDWDDPRLFTLTALRRRGFPPEAINNFCARVG
VTVAQTTMEPHLLEACVRDVLNDTAPRAMAVLESLRVIITNFPAAKSLDIQVPNFPADET
KGFHQVPFAPIVFIERTDFKEEPEPGFKRLAWGQPVGLRHTGYVIELQHVVKGPSGCVES
LEVTCRRADAGEKPKAFIHWVSQPLMCEVRLYERLFQHKNPEDPTEVPGGFLSDLNLASL
HVVDAALVDCSVALAKPFDKFQFERLGYFSVDPDSHQGKLVFNRTVTLKEDPGKV

# Metabolic_Enzyme_27_Number_of_Residues:
775

# Metabolic_Enzyme_27_Molecular_Weight:
87800

# Metabolic_Enzyme_27_Theoretical_pI:
7.16

# Metabolic_Enzyme_27_GO_Classification:
>>>
Function:  glutamate-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  glutamine-tRNA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  glutamyl-tRNA aminoacylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_27_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_27_Specific_Function:
ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)

# Metabolic_Enzyme_27_Pathway:
map00251  Glutamate metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_27_Reaction:
ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)

# Metabolic_Enzyme_27_Pfam_Domain_Function:
PF00749:tRNA-synt_1c;
PF03950:tRNA-synt_1c_C;
PF04558:tRNA_synt_1c_R1;
PF04557:tRNA_synt_1c_R2

# Metabolic_Enzyme_27_Signals:
None

# Metabolic_Enzyme_27_Transmembrane_Regions:
None

# Metabolic_Enzyme_27_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_27_EC_Link:
EC 6.1.1.18

# Metabolic_Enzyme_27_GenBank_ID_Protein:
558586

# Metabolic_Enzyme_27_SwissProt_ID:
SYQ_HUMAN (P47897)

# Metabolic_Enzyme_27_swissprot_Name:
Not Available

# Metabolic_Enzyme_27_Genecard_id:
QARS

# Metabolic_Enzyme_27_Geneatlas_id:
QARS

# Metabolic_Enzyme_27_hgnc_id:
HGNC:9751

# Metabolic_Enzyme_27_PDB_ID:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_27_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_27_Gene_Sequence:
>2328 bp
ATGGCGGCTCTAGACTCCCTGTCGCTCTTCACTAGCCTCGGCCTGAGCGAGCAGAAGGCC
CGCGAGACGCTCAAGAACTCGGCTCTGAGCGCGCAGCTGCGCGAGGCCGCTACTCAGGCT
CAGCAGACCCTGGGTTCCACCATTGACAAAGCTACCGGGATCCTGTTATATGGCTTGGCC
TCCCGACTCAGGGATACCCGGCGTCTCTCCTTCCTTGTAAGCTACATAGCCAGTAAGAAG
ATCCACACTGAGCCCCAGCTAAGCGCTGCCCTTGAGTATGTGCGGAGTCACCCCTTGGAC
CCCATCGACACTGTGGACTTCGAGCGGGAATGTGGCGTGGGTGTCATTGTGACCCCAGAG
CAGATTGAGGAGGCTGTGGAGGCTGCTATTAACAGGCACCGGCCCCAGCTCCTGGTGGAA
CGTTACCATTTCAACATGGGGCTGCTGATGGGAGAGGCTCGGGCTGTGCTGAAGTGGGCA
GATGGCAAAATGATCAAGAATGAAGTGGACATGCAGGTCCTCCACCTTCTGGGCCCCAAG
TTGGAGGCTGATCTGGAGAAGAAGTTCAAGGTGGCAAAAGCTCGGCTAGAAGAAACAGAC
CGGAGGACGGCAAAGGATGTGGTGGAGAATGGCGAGACTGCTGACCAGACCCTGTCTCTG
ATGGAGCAGCTCCGGGGGGAGGCCCTTAAGTTCCACAAGCCTGGTGAGAACTACAAGACC
CCAGGCTATGTGGTCACTCCACACACCATGAATCTACTAAAGCAGCACCTGGAGATTACT
GGTGGGCAGGTACGTACCCGGTTCCCGCCAGAACCCAATGGAATCCTGCATATTGGACAT
GCCAAAGCCATCAATTTCAACTTTGGCTATGCCAAGGCCAACAATGGCATCTGTTTTCTG
CGTTTTGATGACACCAACCCTGAGAAGGAGGAAGCAAAGTTCTTCACGGCCATCTGTGAC
ATGGTAGCCTGGCTAGGCTACACACCTTACAAAGTCACATATGCGTCTGACTATTTTGAC
CAGCTATATGCGTGGGCTGTGGAGCTCATCCGCAGGGGTCTGGCTTATGTGTGCCACCAG
CGAGGAGAGGAGCTCAAAGGCCATAATACTCTGCCTTCACCCTGGAGAGACCGTCCCATG
GAGGAGTCACTGCTGCTCTTTGAGGCAATGCGCAAGGGCAAGTTTTCAGAGGGCGAGGCC
ACACTACGGATGAAGCTGGTGATGGAGGATGGCAAGATGGACCCTGTAGCCTATCGAGTC
AAGTATACACCACACCACCGCACAGGGGACAAATGGTGCATCTATCCCACCTACGACTAC
ACACACTGCCTCTGTGACTCCATCGAGCACATCACTCACTCACTCTGCACCAAGGAATTC
CAGGCCCGACGCTCTTCCTACTTCTGGCTTTGCAATGCACTGGACGTCTATTGCCCTGTG
CAGTGGGAGTATGGCCGCCTCAACCTGCACTATGCTGTTGTCTCTAAGAGGAAGATCCTC
CAGCTTGTAGCAACTGGTGCTGTGCGGGACTGGGATGACCCACGGCTCTTTACACTCACG
GCCCTGCGACGGCGGGGCTTCCCACCTGAGGCCATCAACAACTTCTGTGCCCGGGTGGGA
GTGACTGTGGCACAAACCACAATGGAGCCACATCTTCTAGAAGCCTGTGTGCGTGATGTG
CTGAATGACACAGCCCCACGAGCCATGGCTGTGCTGGAGTCACTACGGGTCATCATCACC
AACTTTCCTGCTGCCAAGTCCTTGGACATCCAGGTGCCCAACTTCCCAGCTGATGAGACC
AAAGGCTTCCATCAGGTTCCCTTTGCACCCATTGTCTTCATTGAGAGGACTGACTTCAAG
GAGGAGCCAGAGCCAGGATTTAAGCGCCTGGCTTGGGGCCAGCCTGTGGGCCTGAGGCAT
ACAGGCTACGTCATTGAGCTGCAGCATGTTGTCAAGGGCCCCAGTGGTTGTGTAGAGAGT
CTGGAGGTGACCTGCAGACGGGCAGATGCTGGAGAGAAGCCAAAGGCCTTTATTCACTGG
GTGTCACAGCCTTTGATGTGTGAGGTTCGCCTCTATGAGCGACTATTCCAGCACAAGAAC
CCTGAAGATCCTACTGAGGTGCCTGGTGGATTTTTAAGTGACCTGAACCTGGCATCACTA
CACGTGGTGGATGCAGCATTAGTGGACTGCTCTGTGGCCCTGGCAAAACCCTTCGACAAG
TTCCAGTTTGAGCGTCTTGGATATTTCTCCGTGGATCCAGACAGCCATCAGGGAAAGCTT
GTCTTTAACCGAACTGTCACACTGAAGGAAGACCCAGGAAAGGTGTGA

# Metabolic_Enzyme_27_GenBank_ID_Gene:
X76013

# Metabolic_Enzyme_27_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_27_Locus:
3p21.3-p21.1

# Metabolic_Enzyme_27_SNPs:
rs5030795; rs4521268; rs4513485; rs13064784; rs4955426; rs11539148; rs5008949; rs1131331; rs1140525; rs13081176; rs35281792; rs35083448; rs34326553; rs13059023; rs35796732; rs13100657; rs35673421; rs4128204; rs34333933; rs7613975; rs13321689; rs14644; rs3212; rs4292260; rs4292261; rs4355315; rs4955411; rs6780307; rs6782515; rs6782540; rs9840050; rs9857248; rs9863398; rs9877045

# Metabolic_Enzyme_27_General_References:
8078941

# Metabolic_Enzyme_27_References:
Not Available

# Metabolic_Enzyme_28_ID:
5853

# Metabolic_Enzyme_28_Name:
Threonyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_28_Synonyms:
Threonine--tRNA ligase; ThrRS

# Metabolic_Enzyme_28_Gene_Name:
TARS

# Metabolic_Enzyme_28_Protein_Sequence:
>ThreonyltRNA synthetase, cytoplasmic
MFEEKASSPSGKMGGEEKPIGAGEEKQKEGGKKKNKEGSGDGGRAELNPWPEYIYTRLEM
YNILKAEHDSILAEKAEKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVIA
KVNNVVWDLDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIE
NGFYYDMYLEEGGVSSNDFSSLEALCKKIIKEKQAFERLEVKKETLLAMFKYNKFKCRIL
NEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKALKIHKNSSTYWEGKADMETLQRIYGI
SFPDPKMLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFI
RSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMF
DHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCL
DFLRTVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFY
GPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERM
IAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNK
KIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAE
EEF

# Metabolic_Enzyme_28_Number_of_Residues:
723

# Metabolic_Enzyme_28_Molecular_Weight:
83436

# Metabolic_Enzyme_28_Theoretical_pI:
6.64

# Metabolic_Enzyme_28_GO_Classification:
>>>
Function:  threonine-tRNA ligase activity
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  transporter activity
Function:  electron transporter activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  threonyl-tRNA aminoacylation
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  protein biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_28_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_28_Specific_Function:
ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)

# Metabolic_Enzyme_28_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_28_Reaction:
ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)

# Metabolic_Enzyme_28_Pfam_Domain_Function:
PF03129:HGTP_anticodon;
PF02824:TGS;
PF00587:tRNA-synt_2b;
PF07973:tRNA_SAD

# Metabolic_Enzyme_28_Signals:
None

# Metabolic_Enzyme_28_Transmembrane_Regions:
None

# Metabolic_Enzyme_28_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_28_EC_Link:
EC 6.1.1.3

# Metabolic_Enzyme_28_GenBank_ID_Protein:
1464742

# Metabolic_Enzyme_28_SwissProt_ID:
SYTC_HUMAN (P26639)

# Metabolic_Enzyme_28_swissprot_Name:
Not Available

# Metabolic_Enzyme_28_Genecard_id:
TARS

# Metabolic_Enzyme_28_Geneatlas_id:
TARS

# Metabolic_Enzyme_28_hgnc_id:
HGNC:11572

# Metabolic_Enzyme_28_PDB_ID:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_28_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_28_Gene_Sequence:
>2139 bp
ATGGGAGGCGAGGAGAAGCCGATTGGTGCTGGTGAAGAGAAGCAAAAGGAAGGAGGCAAA
AAGAAGAACAAAGAAGGATCTGGAGATGGAGGTCGAGCTGAGTTGAATCCTTGGCCTGAA
TATATTTACACACGTCTTGAGATGTATAATATACTAAAAGCAGAACATGATTCCATTCTG
GCAGAAAAGGCAGAAAAAGATAGCAAGCCAATTAAAGTCACTTTGCCTGATGGTAAACAG
GTTGATGCGGAATCTTGGAAAACTACACCATATCAAATTGCCTGTGGAATTAGTCAAGGC
CTGGCCGACAACACCGTTATTGCTAAAGTAAATAATGTTGTGTGGGACCTGGACCGCCCT
CTGGAAGAAGATTGTACCTTGGAGCTTCTCAAGTTTGAGGATGAGGAAGCTCAGGCAGTG
TATTGGCACTCTAGTGCTCACATAATGGGTGAAGGCATGGAAAGAGTCTATGGTGGATGT
TTATGCTACGGTCCGCCAATAGAAAATGGATTCTATTATGACATGTACCTCGAAGAAGGG
GGTGTGTCTAGCAATGATTTCTCTTCTCTGGAGGCTTTGTGTAAGAAAATCATTAAAGAA
AAACAAGCTTTTGAAAGACTGGAAGTTAAGAAAGAAACTTTACTGGCAATGTTTAAGTAC
AACAAGTTCAAATGCCGGATATTGAATGAAAAGGTGAATACTCCAACTACCACAGTCTAT
AGATGTGGCCCTTTGATAGATCTCTGCCGGGGTCCTCATGTTAGACACACGGGCAAAATT
AAGGCTTTAAAAATACACAAAAATTCCTCCACGTACTGGGAAGGCAAAGCAGATATGGAG
ACTCTCCAGAGAATTTATGGCATTTCATTCCCAGATCCTAAAATGTTGAAAGAGTGGGAG
AAGTTCCAAGAGGAAGCTAAAAACCGAGATCATAGGAAAATTGGCAGGGACCAAGAACTA
TATTTCTTTCATGAACTCAGCCCTGGAAGTTGCTTTTTTCTGCCAAAAGGAGTCTATATT
TATAATGCACTTATTGAATTCATTAGGAGCGAATATAGGAAAAGAGGATTCCAGGAGGTA
GTCACCCCAAACATCTTCAACAGCCGACTCTGGATGACCTCGGGCCACTGGCAGCACTAC
AGCGAGAACATGTTCTCCTTTGAGGTGGAGAAGGAGCTGTTTGCCCTGAAACCCATGAAC
TGCCCAGGACACTCCCTTATGTTTGATCATCGGCCAAGGTCCTGGCGAGAACTGCCTCTG
CGGCTAGCTGATTTTGGGGGTCTTCATAGGAACGAGCTGTCTGGAGCACTCACAGGACTC
ACCCGGGTACGAAGATTCCAACAGGATGATGCTCACATATTCTGTGCCATGGAGCAGATT
GAAGATGAAATAAAAGGTTGTTTGGATTTTCTACGTACGGTATATAGCGTATTTGGATTT
TCTTTTAAACTAAACCTTTCTACTCGCCCGGAAAAATTCCTTGGAGATATCGAAGTATGG
GATCAAGCTGAGAAACAACTTGAAAACAGTCTGAATGAATTTGGTGAAAAGTGGGAGTTA
AACTCTGGAGATGGAGCTTTCTATGGCCCAAAGATTGACATACAGATTAAAGATGCGATT
GGGCGGTACCACCAGTGTGCAACCATCCAGCTGGATTTCCAGTTGCCCATCAGATTTAAT
CTTACTTATGTAAGCCATGATGGTGAGGATAAGAAAAGGCCAGTGATTGTTCATCGAGCC
ATCTTGGGATCAGTGGAAAGAATGATTGCTATCCTCACAGAAAACTATGGGGGCAAATTG
GCCCCCTTTTGGCTGTCCCCTCGCCAGGTAATGGTAGTTCCAGTGGGACCAACCTGTGAT
GAATATGCCCAAAACGTACGACAACAATTCCACGATGCCAAATTCATGGCAGACATTGAT
CTGGATCCAGGCTGTACATTGAATAAAAAGATTCGAAATGCACAGTTAGCACAGTATAAC
TTCATTTTAGTTGTTGGTGAAAAAGAGAAAATCACTGGCACTGTTAATATCCGCACAAGA
GACAATAAGGTCCACGGGGAACGCACCATTTCTGAAACTATCGAGCGGCTACAGCAGCTC
AAAGAGTTCCGCAGCAAACAGGCAGAAGAAGAATTTTAA

# Metabolic_Enzyme_28_GenBank_ID_Gene:
M63180

# Metabolic_Enzyme_28_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_28_Locus:
5p13.2

# Metabolic_Enzyme_28_SNPs:
rs16891129; rs34334786; rs2270902; rs3736393; rs2270905; rs7261; rs2304621; rs28362597; rs3765145; rs1003000; rs6450990; rs893551; rs2292015; rs3849682; rs3777083; rs3777081; rs3777079; rs7705177; rs6887261; rs6884566; rs3765146; rs2270903; rs3777077; rs3777076; rs3777082; rs6893613; rs16891189; rs10941055; rs9686398; rs12659798; rs6450991; rs3777075; rs11955272; rs11955289; rs3777074; rs3849683; rs3765144; rs3765147; rs3777078; rs6885094; rs12522185; rs6866808; rs16891141; rs6880623; rs3830415; rs12517884; rs4867513; rs4421109; rs3215116; rs6880616; rs16891180; rs2270904; rs4867512; rs16891143; rs2292014; rs3777073; rs7734078; rs12520517; rs3756661; rs3756664; rs3756663; rs3756662; rs6870521; rs11742862; rs16891125; rs1804513; rs1051213; rs11541416; rs1051210; rs1131566; rs1051211; rs34715628; rs16891192; rs34673293; rs33932086; rs17565038; rs12187755; rs5867191; rs35931457; rs5022546; rs10583985; rs11356243; rs12187715; rs2642668; rs34875186; rs28475744; rs3842066; rs35121278; rs34630295; rs9885230; rs12187727; rs12188515; rs35817175; rs11747025; rs11457738; rs13154531; rs4267874; rs34910729; rs34725061; rs4398642; rs1687511; rs2642669; rs35375523; rs13184927; rs34596299; rs11952399; rs3777080; rs11414360; rs11383852; rs11422595; rs13164529; rs11960553; rs34580645; rs34374932; rs17455135; rs5867190; rs35331115; rs35079782; rs5867189; rs2453288; rs2164991; rs6889780; rs36102914; rs35558849; rs1080; rs11950608; rs12054982; rs12514530; rs1438728; rs1542031; rs1542998; rs16891198; rs16891202; rs4867143; rs6885517; rs7702124; rs925210

# Metabolic_Enzyme_28_General_References:
2033077

# Metabolic_Enzyme_28_References:
Not Available

# Metabolic_Enzyme_29_ID:
5610

# Metabolic_Enzyme_29_Name:
Glycogen phosphorylase, muscle form

# Metabolic_Enzyme_29_Synonyms:
Myophosphorylase

# Metabolic_Enzyme_29_Gene_Name:
PYGM

# Metabolic_Enzyme_29_Protein_Sequence:
>Glycogen phosphorylase, muscle form
MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTV
RDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDM
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEA
DDWLRYGNPWEKARPEFTLPVHFYGHVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVN
TMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERM
DWDKAWDVTVRTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFP
GDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKF
QNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLDQLRKLLSFVDDEAFIRDVAKVKQ
ENKLKFAAYLEREYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKREPNKFFV
PRTVMIGGKAAPGYHMAKMIIRLVTAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPA
ADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVD
KLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYED
YIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE
AI

# Metabolic_Enzyme_29_Number_of_Residues:
842

# Metabolic_Enzyme_29_Molecular_Weight:
97093

# Metabolic_Enzyme_29_Theoretical_pI:
7.03

# Metabolic_Enzyme_29_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
Function:  phosphorylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_29_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_29_Specific_Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

# Metabolic_Enzyme_29_Pathway:
map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_29_Reaction:
(1,4-alpha-D-glucosyl)n + phosphate = (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate

# Metabolic_Enzyme_29_Pfam_Domain_Function:
PF00343:Phosphorylase

# Metabolic_Enzyme_29_Signals:
None

# Metabolic_Enzyme_29_Transmembrane_Regions:
None

# Metabolic_Enzyme_29_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_29_EC_Link:
EC 2.4.1.1

# Metabolic_Enzyme_29_GenBank_ID_Protein:
190784

# Metabolic_Enzyme_29_SwissProt_ID:
PYGM_HUMAN (P11217)

# Metabolic_Enzyme_29_swissprot_Name:
Not Available

# Metabolic_Enzyme_29_Genecard_id:
PYGM

# Metabolic_Enzyme_29_Geneatlas_id:
PYGM

# Metabolic_Enzyme_29_hgnc_id:
HGNC:9726

# Metabolic_Enzyme_29_PDB_ID:
1XL1

# Metabolic_Enzyme_29_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_29_Subcellular_Location:
Not Available

# Metabolic_Enzyme_29_Gene_Sequence:
>2529 bp
ATGTCCCGGCCCCTGTCAGACCAAGAGAAAAGAAAGCAAATCAGTGTGCGTGGCCTGGCC
GGCGTGGAGAACGTGACTGAGCTGAAAAAGAACTTCAACCGGCACCTGCATTTCACACTC
GTAAAGGACCGCAATGTGGCCACCCCACGAGACTACTACTTTGCTCTGGCCCATACCGTG
CGCGACCACCTCGTGGGGCGGTGGATCCGCACGCAGCAGCACTACTATGAGAAGGACCCC
AAGAGGATCTACTACCTGTCTTTAGAGTTCTATATGGGACGGACGCTACAGAACACCATG
GTGAACCTGGCCTTAGAGAATGCCTGTGACGAGGCCACCTACCAGCTGGGCCTGGACATG
GAGGAGCTGGAGGAAATTGAGGAGGATGCGGGGCTGGGCAACGGGGGCCTGGGCCGGCTG
GCAGCCTGCTTTCTTGACTCCATGGCAACACTGGGCCTGGCTGCCTATGGCTACGGGATT
CGCTATGAGTTTGGGATTTTTAACCAGAAGATCTCCGGGGGCTGGCAGATGGAGGAGGCC
GATGACTGGCTTCGCTACGGCAACCCCTGGGAGAAGGCCCGGCCCGAGTTCACGCTACCT
GTGCACTTCTACGGCCATGTGGAGCACACCAGCCAGGGTGCCAAGTGGGTGGACACACAG
GTGGTACTGGCCATGCCCTACGATACCCCGGTGCCTGGCTATCGCAACAATGTTGTCAAC
ACCATGCGCCTCTGGTCTGCCAAGGCTCCCAATGACTTCAACCTCAAGGACTTCAATGTC
GGTGGCTACATCCAGGCTGTGTTGGACCGAAACCTGGCGGAGAACATCTCTCGTGTCCTG
TACCCCAATGATAATTTCTTCGAAGGGAAGGAGCTGCGGCTGAAGCAGGAGTATTTCGTG
GTGGCTGCCACCCTCCAGGACATCATCCGTCGCTTCAAGTCTTCCAAGTTCGGCTGCCGT
GATCCCGTGCGCACGAACTTCGATGCCTTCCCAGATAAGGTGGCCATCCAGCTCAATGAC
ACCCACCCCTCCCTGGCCATCCCCGAGCTGATGAGGATCCTGGTGGACCTGGAACGGATG
GACTGGGACAAGGCGTGGGATGTGACAGTGAGGACCTGTGCCTACACCAACCACACGGTG
CTGCCCGAGGCCCTGGAGCGCTGGCCGGTGCACCTCTTGGAGACGCTGCTGCCGCGGCAC
CTCCAGATCATCTACGAGATCAACCAGCGCTTCCTCAACCGGGTGGCGGCCGCATTCCCA
GGGGACGTAGACCGGCTGCGGCGCATGTCGCTGGTGGAGGAGGGCGCAGTGAAGCGCATC
AACATGGCACACCTGTGCATCGCGGGGTCGCACGCCGTCAACGGTGTGGCCCGCATCCAC
TCGGAGATCCTCAAGAAGACCATCTTCAAAGACTTCTATGAGCTGGAGCCTCATAAGTTC
CAGAATAAGACCAACGGCATCACCCCTCGGCGCTGGCTGGTTCTGTGTAACCCCGGGCTG
GCAGAGGTCATTGCTGAGCGCATCGGGGAGGACTTCATCTCTGACCTGGACCAGCTGCGC
AAACTGCTCTCCTTTGTGGATGATGAAGCTTTCATTCGGGATGTGGCCAAAGTGAAGCAG
GAAAACAAGTTGAAGTTTGCTGCCTACCTAGAGAGGGAATACAAAGTCCACATCAACCCC
AACTCACTCTTCGACATCCAGGTGAAGCGGATTCACGAATATAAACGACAGCTCCTCAAC
TGCCTCCATGTCATCACCCTGTACAACCGCATCAAGAGGGAGCCCAATAAGTTTTTTGTG
CCTCGGACTGTGATGATTGGAGGGAAGGCTGCACCTGGGTACCACATGGCCAAGATGATC
ATCAGACTCGTCACAGCCATCGGGGATGTGGTCAACCATGACCCGGCAGTGGGTGACCGC
CTCCGTGTCATCTTCCTGGAGAACTACCGAGTCTCACTGGCCGAGAAAGTGATCCCAGCT
GCAGACCTCTCTGAGCAGATCTCCACTGCGGGCACTGAAGCCTCAGGCACCGGCAACATG
AAGTTCATGCTCAACGGGGCTCTGACCATTGGCACCATGGACGGGGCCAATGTGGAGATG
GCAGAAGAGGCGGGAGAGGAAAACTTCTTCATCTTTGGCATGCGGGTGGAGGATGTGGAT
AAGCTTGACCAAAGAGGGTACAATGCCCAGGAGTACTACGATCGCATTCCTGAGCTTCGG
CAGGTCATTGAGCAGCTGAGCAGTGGCTTCTTCTCCCCCAAACAACCCGACCTGTTCAAG
GACATTGTCAATATGCTCATGCACCATGACCGGTTTAAAGTCTTCGCAGATTATGAAGAC
TACATTAAATGCCAGGAGAAAGTCAGCGCCTGGTACAAGAACCCAAGAGAGTGGACGCGG
ATGGTGATCCGGAACATAGCCACTTCTGGCAAGTTCTCCAGTGACCGCACCATTGCCCAG
TATGCCCGGGAGATCTGGGGTGTGGAGCCTTCCCGCCAGCGCCTGCCAGCCCCGGATGAG
GCCATCTGA

# Metabolic_Enzyme_29_GenBank_ID_Gene:
M32598

# Metabolic_Enzyme_29_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_29_Locus:
11q12-q13.2

# Metabolic_Enzyme_29_SNPs:
rs483962; rs489192; rs686171; rs547066; rs477549; rs565688; rs490980; rs7938455; rs592521; rs589691; rs625172; rs592532; rs506354; rs532747; rs592546; rs474006; rs7126110; rs2959652; rs566653; rs630966; rs637332; rs11821081; rs604595; rs11231866; rs2230309; rs1212604; rs11231865; rs1056780; rs28940587; rs669572; rs12278323; rs9704315; rs34267133; rs3202054; rs576632; rs34991365; rs2071320; rs34447097; rs34154523; rs608261; rs28398896; rs1207113; rs550545; rs555974; rs7114931; rs569200; rs608257; rs7104895; rs34195091; rs35447888; rs34978393; rs2071318; rs11308610; rs12364023; rs2284302; rs34338262; rs35958437; rs35091627; rs35071540; rs1803954; rs1804549; rs2073797; rs2073798; rs2277308; rs2277309; rs2301563; rs2904961; rs2959650; rs3168088; rs3759049; rs3759051; rs3759052; rs3891505; rs484886; rs523200; rs546323; rs547280; rs550930; rs561158; rs588139; rs610637; rs620006; rs637732; rs681791

# Metabolic_Enzyme_29_General_References:
3447177; 3840433; 3466902; 8316268; 8535454; 7603523; 9506549; 10417800; 10382911; 10382912; 10681080; 10590419; 10714589; 10899452; 11706962; 12031624

# Metabolic_Enzyme_29_References:
Not Available

# Metabolic_Enzyme_30_ID:
5854

# Metabolic_Enzyme_30_Name:
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

# Metabolic_Enzyme_30_Synonyms:
cGMP phosphodiesterase 6C

# Metabolic_Enzyme_30_Gene_Name:
PDE6C

# Metabolic_Enzyme_30_Protein_Sequence:
>Cone cGMPspecific 3',5'cyclic phosphodiesterase subunit alpha'
MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESA
LCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPT
SKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLL
ATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRS
QILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGE
VEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICN
MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEY
ITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVD
VIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKV
PVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF
CHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET
VIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMT
ACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFI
DFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKA
AEDSGGGDDKKSKTCLML

# Metabolic_Enzyme_30_Number_of_Residues:
858

# Metabolic_Enzyme_30_Molecular_Weight:
99148

# Metabolic_Enzyme_30_Theoretical_pI:
5.45

# Metabolic_Enzyme_30_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_30_General_Function:
Not Available

# Metabolic_Enzyme_30_Specific_Function:
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate

# Metabolic_Enzyme_30_Pathway:
Not Available

# Metabolic_Enzyme_30_Reaction:
guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate

# Metabolic_Enzyme_30_Pfam_Domain_Function:
PF01590:GAF;
PF00233:PDEase_I

# Metabolic_Enzyme_30_Signals:
None

# Metabolic_Enzyme_30_Transmembrane_Regions:
None

# Metabolic_Enzyme_30_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_30_EC_Link:
EC 3.1.4.35

# Metabolic_Enzyme_30_GenBank_ID_Protein:
940231

# Metabolic_Enzyme_30_SwissProt_ID:
PDE6C_HUMAN (P51160)

# Metabolic_Enzyme_30_swissprot_Name:
Not Available

# Metabolic_Enzyme_30_Genecard_id:
PDE6C

# Metabolic_Enzyme_30_Geneatlas_id:
PDE6C

# Metabolic_Enzyme_30_hgnc_id:
HGNC:8787

# Metabolic_Enzyme_30_PDB_ID:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_30_Subcellular_Location:
Cell membrane; lipid-anchor; cytoplasmic side (Potential)

# Metabolic_Enzyme_30_Gene_Sequence:
>2577 bp
ATGGGTGAGATCAACCAAGTTGCCGTGGAGAAATACCTGGAGGAGAACCCTCAGTTTGCC
AAGGAGTACTTTGACAGGAAGTTGCGGGTGGAGGTGCTGGGAGAAATCTTCAAGAACAGC
CAGGTGCCAGTCCAGTCCAGCATGTCCTTCTCTGAGCTGACCCAGGTGGAGGAGTCAGCC
CTGTGCTTGGAGCTGCTGTGGACCGTGCAGGAGGAGGGGGGCACCCCAGAGCAGGGGGTT
CACAGGGCCCTACAGAGGCTGGCCCACCTGCTCCAGGCTGACCGCTGCAGCATGTTCCTG
TGCCGGTCCCGGAACGGCATACCTGAGGTGGCCTCTAGGTTGCTGGTAGTCACCCCCACC
TCCAAGTTTGAGGACAACCTGGTGGGCCCTGACAAAGAAGTTGTGTTTCCATTGGACATT
GGGATAGTGGGTTGGGCTGCTCACACGAAGAAAACTCATAATGTCCCAGATGTGAAAAAG
AACAGCCATTTTTCTGACTTCATGGACAAGCAAACTGGGTATGTCACTAAGAACCTGCTG
GCAACCCCGATCGTGGTGGGCAAGGAGGTTCTTGCTGTGATCATGGCAGTTAACAAAGTA
AATGCATCTGAATTTTCCAAACAGGATGAAGAGGTCTTTTCCAAATACCTCAACTTTGTG
TCTATCATCCTAAGGCTTCATCACACCAGCTACATGTACAATATTGAATCCCGAAGAAGC
CAGATCCTTATGTGGTCAGCCAATAAAGTATTTGAAGAACTCACAGATGTTGAGCGACAG
TTTCACAAAGCGCTCTACACGGTTAGATCATATCTGAACTGTGAACGATACTCCATTGGA
CTGCTGGACATGACCAAGGAGAAGGAATTCTACGATGAATGGCCAATCAAGCTTGGAGAA
GTAGAGCCTTATAAAGGTCCAAAGACACCTGATGGCAGGGAAGTCAACTTTTATAAAATC
ATTGATTACATTTTACATGGAAAAGAAGAGATCAAAGTGATTCCGACGCCTCCTGCAGAC
CACTGGACACTCATTAGTGGGTTGCCAACATATGTTGCTGAAAATGGATTTATCTGTAAC
ATGATGAATGCCCCTGCGGATGAATACTTCACATTTCCGAAAGGACCTGTAGACGAAACT
GGTTGGGTCATTAAGAATGTTTTGTCCCTGCCTATTGTCAACAAGAAAGAAGATATTGTG
GGAGTGGCTACATTTTACAACAGGAAGGATGGAAAACCTTTCGATGAGCATGATGAATAC
ATTACCGAGACTCTCACACAATTTCTTGGATGGTCTCTTTTAAATACTGACACCTACGAT
AAGATGAATAAGCTAGAAAACAGAAAGGACATTGCTCAGGAAATGCTCATGAACCAAACC
AAAGCCACTCTTGAAGAAATTAAGTCCATTTTGAAATTTCAAGAGAAGTTAAATGTTGAT
GTAATTGACGACTGTGAAGAAAAACAACTTGTTGCAATTTTGAAAGAGGACTTGCCAGAC
CCACGCTCAGCAGAACTGTACGAATTCCGCTTCAGTGACTTCCCCCTTACAGAGCACGGA
TTGATTAAATGTGGAATACGACTGTTTTTTGAAATAAATGTGGTGGAGAAATTCAAAGTA
CCTGTAGAGGTTCTTACCAGATGGATGTACACTGTGAGGAAAGGGTACCGAGCTGTCACT
TACCACAATTGGCAGCATGGGTTCAACGTGGGGCAGACCATGTTTACTTTGCTGATGACA
GGAAGATTAAAGAAGTACTACACAGATCTCGAAGCCTTTGCCATGCTTGCTGCTGCTTTC
TGCCATGATATTGACCACAGAGGCACCAATAATTTGTACCAGATGAAATCCACGTCTCCA
TTAGCAAGACTTCATGGTTCTTCTATTTTGGAGAGGCACCACCTGGAGTACAGTAAGACT
CTGTTGCAGGATGAGAGTTTAAACATCTTCCAGAACCTAAATAAGCGGCAGTTTGAAACA
GTTATTCATTTGTTCGAGGTCGCAATAATAGCAACTGACCTGGCTTTATATTTCAAGAAG
AGGACCATGTTTCAAAAAATTGTTGATGCCTGTGAACAAATGCAAACGGAAGAAGAAGCC
ATCAAATATGTAACTGTTGATCCAACCAAGAAAGAGATTATCATGGCAATGATGATGACG
GCATGTGACTTGTCTGCTATTACCAAGCCCTGGGAGGTGCAAAGTCAGGTAGCACTTATG
GTTGCAAATGAATTTTGGGAACAAGGAGATCTGGAGAGAACAGTGTTGCAGCAACAACCC
ATTCCTATGATGGACAGAAACAAAAGAGATGAATTACCTAAACTTCAAGTTGGATTTATT
GATTTTGTTTGTACTTTTGTATATAAGGAGTTCTCACGGTTTCACAAAGAAATCACACCT
ATGCTGAGTGGTCTTCAGAATAACAGAGTAGAATGGAAATCACTAGCTGATGAGTATGAT
GCAAAGATGAAGGTCATTGAAGAGGAGGCAAAAAAGCAAGAAGGAGGAGCCGAAAAAGCT
GCTGAAGATTCAGGAGGTGGTGATGACAAAAAGTCCAAAACATGTTTAATGTTGTAA

# Metabolic_Enzyme_30_GenBank_ID_Gene:
U31973

# Metabolic_Enzyme_30_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_30_Locus:
10q24

# Metabolic_Enzyme_30_SNPs:
rs701865; rs714550; rs3737228; rs1131978; rs12781149; rs554062; rs650058; rs588912; rs2077733; rs616522; rs637959; rs1326217; rs1223306; rs2422324; rs487161; rs1409332; rs716333; rs2104497; rs2422326; rs591392; rs2857300; rs1147644; rs1018634; rs913046; rs7080485; rs829107; rs2785137; rs6583900; rs720298; rs725888; rs10786119; rs4917871; rs10882289; rs503758; rs11187554; rs2857293; rs604489; rs12266365; rs10748607; rs481031; rs3781273; rs2901714; rs7903947; rs620043; rs1147645; rs677517; rs7095788; rs1147643; rs640090; rs3824752; rs1326219; rs583830; rs1223308; rs10786121; rs10882291; rs714549; rs12249716; rs716332; rs2275227; rs473934; rs517785; rs4919340; rs829109; rs7919662; rs7080650; rs1409334; rs11187570; rs17485621; rs559590; rs618951; rs659145; rs564626; rs547759; rs10882294; rs1326218; rs3781279; rs620890; rs10882288; rs1764322; rs7076251; rs714551; rs10882292; rs11187574; rs6583901; rs2422327; rs11187573; rs2765828; rs12412552; rs12264082; rs590226; rs1409335; rs10882293; rs1409333; rs1223307; rs17109153; rs10882297; rs17109017; rs2148295; rs2094210; rs9419777; rs12260939; rs10882298; rs12265671; rs1856563; rs1147642; rs2148296; rs515656; rs17109134; rs12252727; rs4919314; rs2184777; rs2014325; rs7476647; rs10882287; rs11187560; rs17109081; rs11187575; rs17407606; rs17109131; rs2785140; rs10882296; rs12261871; rs7075895; rs10882290; rs7097667; rs7095955; rs11814998; rs7917510; rs11187566; rs11187572; rs11187555; rs7893369; rs12217346; rs12261990; rs11187578; rs6583903; rs2857302; rs2422325; rs2785144; rs11187571; rs7910799; rs4454655; rs11187577; rs11187563; rs12217337; rs11187556; rs2009687; rs11814382; rs4919339; rs1223305; rs7094543; rs1223295; rs12246423; rs11187561; rs11187569; rs4282926; rs11187564; rs10786120; rs7893372; rs1223309; rs12251269; rs11187562; rs1096025; rs6583902; rs4919344; rs12252137; rs12266501; rs12260671; rs11597224; rs12261131; rs41290222; rs1051925; rs1051926; rs2785143; rs34556446; rs35991228; rs2785136; rs1934332; rs12244942; rs7091068; rs12780304; rs35383563; rs2857298; rs35646712; rs2857296; rs685932; rs11458791; rs12220088; rs1223296; rs11187559; rs11187568; rs2184776; rs2785142; rs10576959; rs2859742; rs3781276; rs2859743; rs12784096; rs2857297; rs11187576; rs4322325; rs7901817; rs2857295; rs12246400; rs3781272; rs3831275; rs7100627; rs11187553; rs2785138; rs5787071; rs35142602; rs35544970; rs35302473; rs7897417; rs7084398; rs36000137; rs35178949; rs2765830; rs10691352; rs11187565; rs514120; rs1934333; rs2785139; rs7900772; rs34173771; rs2765831; rs10680592; rs4919390; rs35484151; rs1750634; rs34507085; rs7903992; rs12049686; rs35175655; rs7909769; rs34414687; rs4539248; rs4590795; rs35868180; rs10666338; rs36102645; rs35822924; rs7904127; rs10699606; rs2484928; rs587034; rs1096027; rs5787069; rs12254107; rs34756107; rs3904734; rs3085185; rs35818357; rs11364728; rs2857301; rs34861265; rs1096026; rs2765829; rs7907905; rs11187557; rs11418985; rs10548834; rs34919813; rs4558100; rs11187552; rs12220915; rs34008461; rs634750; rs34327978; rs4917865; rs34108261; rs2857299; rs35656775; rs3085187; rs474709; rs41303821; rs12412251; rs1326216; rs1013889; rs11187558; rs2785134; rs35245452; rs7475724; rs12779737; rs12260900; rs2857294; rs2785133; rs12260745; rs9419778; rs12260744; rs10159893; rs10786117; rs1108197; rs11187549; rs11187579; rs11187580; rs12219497; rs12255765; rs12265776; rs12415773; rs12573026; rs1326215; rs1547173; rs1572772; rs1572773; rs17108993; rs17108996; rs17486669; rs34803976; rs35180415; rs3740369; rs3765581; rs4144098; rs7904844; rs913045

# Metabolic_Enzyme_30_General_References:
7490077

# Metabolic_Enzyme_30_References:
Not Available

# Metabolic_Enzyme_31_ID:
5233

# Metabolic_Enzyme_31_Name:
Cytosolic 5'-nucleotidase 1A

# Metabolic_Enzyme_31_Synonyms:
Cytosolic 5'-nucleotidase IA; cN1A; cN-IA; cN-I

# Metabolic_Enzyme_31_Gene_Name:
NT5C1A

# Metabolic_Enzyme_31_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
AMEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSR
ALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSED
VFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKV
REAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKA
HENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSW
GLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTA
PAKQAPSAQ

# Metabolic_Enzyme_31_Number_of_Residues:
368

# Metabolic_Enzyme_31_Molecular_Weight:
41021

# Metabolic_Enzyme_31_Theoretical_pI:
6.52

# Metabolic_Enzyme_31_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_31_General_Function:
Not Available

# Metabolic_Enzyme_31_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia

# Metabolic_Enzyme_31_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_31_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_31_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_31_Signals:
None

# Metabolic_Enzyme_31_Transmembrane_Regions:
None

# Metabolic_Enzyme_31_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_31_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_31_GenBank_ID_Protein:
12659324

# Metabolic_Enzyme_31_SwissProt_ID:
5NT1A_HUMAN (Q9BXI3)

# Metabolic_Enzyme_31_swissprot_Name:
Not Available

# Metabolic_Enzyme_31_Genecard_id:
NT5C1A

# Metabolic_Enzyme_31_Geneatlas_id:
NT5C1A

# Metabolic_Enzyme_31_hgnc_id:
HGNC:17819

# Metabolic_Enzyme_31_PDB_ID:
Not Available

# Metabolic_Enzyme_31_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_31_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_31_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_31_Gene_Sequence:
>1107 bp
ATGGAACCTGGGCAGCCCCGGGAGCCCCAGGAGCCCCGCGAGCCCGGGCCAGGAGCGGAG
ACCGCTGCGGCCCCGGTCTGGGAGGAAGCCAAGATTTTCTACGACAACCTCGCGCCCAAG
AAGAAACCCAAATCGCCCAAGCCTCAGAATGCAGTCACCATCGCTGTGTCCTCCCGAGCC
TTGTTTCGCATGGACGAGGAGCAGCAGATCTACACGGAGCAGGGCGTGGAGGAGTACGTG
CGCTACCAGCTGGAACATGAGAACGAACCCTTCAGTCCCGGGCCAGCCTTCCCTTTTGTG
AAGGCTCTGGAGGCCGTGAACAGGCGGCTGCGGGAGCTGTACCCTGATAGTGAGGACGTC
TTCGACATCGTCCTCATGACTAACAACCATGCTCAAGTGGGTGTCCGCCTCATCAACAGT
ATCAACCACTATGACCTGTTCATCGAGAGGTTCTGCATGACAGGTGGGAACAGCCCGATC
TGCTACCTCAAGGCCTATCACACCAACCTCTACTTGTCAGCCGATGCGGAAAAAGTGCGA
GAAGCCATTGATGAGGGGATCGCAGCTGCCACCATCTTCAGCCCCAGCAGGGATGTGGTT
GTGTCCCAGAGTCAGCTGCGCGTGGCCTTCGATGGGGACGCCGTGCTCTTCTCGGACGAG
TCGGAGCGCATCGTCAAGGCCCACGGGCTGGACCGATTCTTCGAGCATGAGAAGGCCCAC
GAGAACAAGCCTCTGGCTCAGGGCCCCTTAAAGGGCTTTCTGGAGGCACTGGGTAGGTTG
CAGAAGAAGTTCTACTCCAAAGGCCTGCGGCTGGAGTGCCCAATTCGTACCTACTTGGTG
ACAGCACGCAGTGCAGCCAGTTCCGGGGCCCGGGCTCTCAAGACCCTGCGCAGCTGGGGC
CTGGAGACAGATGAAGCCTTGTTCCTTGCTGGAGCGCCCAAGGGCCCTCTCCTTGAGAAG
ATCCGCCCACACATCTTCTTTGATGACCAGATGTTCCATGTGGCTGGGGCTCAGGAGATG
GGCACTGTGGCCGCCCATGTGCCTTATGGTGTGGCACAGACACCCCGGCGGACTGCACCT
GCAAAGCAGGCCCCATCTGCACAGTAG

# Metabolic_Enzyme_31_GenBank_ID_Gene:
AF331801

# Metabolic_Enzyme_31_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_31_Locus:
1p34.3-p33

# Metabolic_Enzyme_31_SNPs:
rs4660340; rs784611; rs752667; rs1180272; rs1180271; rs784595; rs873917; rs1568146; rs1535031; rs3851911; rs17264901; rs784596; rs12566856; rs12406284; rs11807200; rs784597; rs784610; rs734497; rs3806428; rs784600; rs11809004; rs7553293; rs3806433; rs16826428; rs9660121; rs784599; rs3806429; rs784612; rs1533479; rs2871601; rs41264507; rs34479837; rs12035327; rs1180270; rs9439008; rs35574502; rs34779558; rs36025518; rs36123767; rs35625235; rs28507686; rs35550484; rs11206573; rs41264509; rs784598; rs34604809; rs1535030; rs5773668; rs1517187; rs12039176; rs28592113; rs784594; rs9438930; rs11306359; rs35355327; rs6684666; rs34908371; rs28667717; rs3806432; rs5773667; rs7416372; rs34045723; rs6672154; rs35002774; rs35256759; rs3806431; rs12042601; rs10465833; rs1062103; rs10839; rs10888919; rs10888929; rs11206525; rs1180275; rs1180277; rs12039225; rs12042356; rs12565281; rs13315; rs16826440; rs17501838; rs17560858; rs2281302; rs2746057; rs3207766; rs3806434; rs3916165; rs6663003; rs6703320; rs704769; rs736009; rs7419080; rs784601; rs784602; rs784613; rs784615; rs784616; rs784627; rs784629; rs784630; rs813052

# Metabolic_Enzyme_31_General_References:
11133996

# Metabolic_Enzyme_31_References:
Not Available

# Metabolic_Enzyme_32_ID:
5855

# Metabolic_Enzyme_32_Name:
Asparagine synthetase [glutamine-hydrolyzing]

# Metabolic_Enzyme_32_Synonyms:
Glutamine- dependent asparagine synthetase; Cell cycle control protein TS11

# Metabolic_Enzyme_32_Gene_Name:
ASNS

# Metabolic_Enzyme_32_Protein_Sequence:
>Asparagine synthetase glutaminehydrolyzing
MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRLAVVDPLFGMQ
PIRVKKYPYLWLCYNGEIYNHKKMQQHFEFEYQTKVDGEIILHLYDKGGIEQTICMLDGV
FAFVLLDTANKKVFLGRDTYGVRPLFKAMTEDGFLAVCSEAKGLVTLKHSATPFLKVEPF
LPGHYEVLDLKPNGKVASVEMVKYHHCRDVPLHALYDNVEKLFPGFEIETVKNNLRILFN
NAVKKRLMTDRRIGCLLSGGLDSSLVAATLLKQLKEAQVQYPLQTFAIGMEDSPDLLAAR
KVADHIGSEHYEVLFNSEEGIQALDEVIFSLETYDITTVRASVGMYLISKYIRKNTDSVV
IFSGEGSDELTQGYIYFHKAPSPEKAEEESERLLRELYLFDVLRADRTTAAHGLELRVPF
LDHRFSSYYLSLPPEMRIPKNGIEKHLLRETFEDSNLIPKEILWRPKEAFSDGITSVKNS
WFKILQEYVEHQVDDAMMANAAQKFPFNTPKTKEGYYYRQVFERHYPGRADWLSHYWMPK
WINATDPSARTLTHYKSAVKA

# Metabolic_Enzyme_32_Number_of_Residues:
561

# Metabolic_Enzyme_32_Molecular_Weight:
64371

# Metabolic_Enzyme_32_Theoretical_pI:
6.85

# Metabolic_Enzyme_32_GO_Classification:
>>>
Function:  asparagine synthase (glutamine-hydrolyzing) activity
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Function:  asparagine synthase (glutamine-hydrolyzing) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aspartate family amino acid metabolism
Process:  asparagine metabolism
Process:  asparagine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_32_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_32_Specific_Function:
ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate

# Metabolic_Enzyme_32_Pathway:
map00252  Alanine and aspartate metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_32_Reaction:
ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate

# Metabolic_Enzyme_32_Pfam_Domain_Function:
PF00733:Asn_synthase;
PF00310:GATase_2

# Metabolic_Enzyme_32_Signals:
None

# Metabolic_Enzyme_32_Transmembrane_Regions:
None

# Metabolic_Enzyme_32_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_32_EC_Link:
EC 6.3.5.4

# Metabolic_Enzyme_32_GenBank_ID_Protein:
179100

# Metabolic_Enzyme_32_SwissProt_ID:
ASNS_HUMAN (P08243)

# Metabolic_Enzyme_32_swissprot_Name:
Not Available

# Metabolic_Enzyme_32_Genecard_id:
ASNS

# Metabolic_Enzyme_32_Geneatlas_id:
ASNS

# Metabolic_Enzyme_32_hgnc_id:
HGNC:753

# Metabolic_Enzyme_32_PDB_ID:
Not Available

# Metabolic_Enzyme_32_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_32_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_32_Subcellular_Location:
Not Available

# Metabolic_Enzyme_32_Gene_Sequence:
>1686 bp
ATGTGTGGCATTTGGGCGCTGTTTGGCAGTGATGATTGCCTTTCTGTTCAGTGTCTGAGT
GCTATGAAGATTGCACACAGAGGTCCAGATGCATTCCGTTTTGAGAATGTCAATGGATAC
ACCAACTGCTGCTTTGGATTTCACCGGTTGGCGGTAGTTGACCCGCTGTTTGGAATGCAG
CCAATTCGAGTGAAGAAATATCCGTATTTGTGGCTCTGTTACAATGGTGAAATCTACAAC
CATAAGAAGATGCAACAGCATTTTGAATTTGAATACCAGACCAAAGTGGATGGTGAGATA
ATCCTTCATCTTTATGACAAAGGAGGAATTGAGCAAACAATTTGTATGTTGGATGGTGTG
TTTGCATTTGTTTTACTGGATACTGCCAATAAGAAAGTGTTCCTGGGTAGAGATACATAT
GGAGTCAGACCTTTGTTTAAAGCAATGACAGAAGATGGATTTTTGGCTGTATGTTCAGAA
GCTAAAGGTCTTGTTACATTGAAGCACTCCGCGACTCCCTTTTTAAAAGTGGAGCCTTTT
CTTCCTGGACACTATGAAGTTTTGGATTTAAAGCCAAATGGCAAAGTTGCATCCGTGGAA
ATGGTTAAATATCATCACTGTCGGGATGTACCCCTGCACGCCCTCTATGACAATGTGGAG
AAACTCTTTCCAGGTTTTGAGATAGAAACTGTGAAGAACAACCTCAGGATCCTTTTTAAT
AATGCTGTAAAGAAACGTTTGATGACAGACAGAAGGATTGGCTGCCTTTTATCAGGGGGC
TTGGACTCCAGCTTGGTTGCTGCCACTCTGTTGAAGCAGCTGAAAGAAGCCCAAGTACAG
TATCCTCTCCAGACATTTGCAATTGGCATGGAAGACAGCCCCGATTTACTGGCTGCTAGA
AAGGTGGCAGATCATATTGGAAGTGAACATTATGAAGTCCTTTTTAACTCTGAGGAAGGC
ATTCAGGCTCTGGATGAAGTCATATTTTCCTTGGAAACTTATGACATTACAACAGTTCGT
GCTTCAGTAGGTATGTATTTAATTTCCAAGTATATTCGGAAGAACACAGATAGCGTGGTG
ATCTTCTCTGGAGAAGGATCAGATGAACTTACGCAGGGTTACATATATTTTCACAAGGCT
CCTTCTCCTGAAAAAGCCGAGGAGGAGAGTGAGAGGCTTCTGAGGGAACTCTATTTGTTT
GATGTTCTCCGCGCAGATCGAACTACTGCTGCCCATGGTCTTGAACTGAGAGTCCCATTT
CTAGATCATCGATTTTTTTCCTATTACTTGTCTCTGCCACCAGAAATGAGAATTCCAAAG
AATGGGATAGAAAAACATCTCCTGAGAGAGACGTTTGAGGATTCCAATCTGATACCCAAA
GAGATTCTCTGGCGACCAAAAGAAGCCTTCAGTGATGGAATAACTTCAGTTAAGAATTCC
TGGTTTAAGATTTTACAGGAATACGTTGAACATCAGGTTGATGATGCAATGATGGCAAAT
GCAGCCCAGAAATTTCCCTTCAATACTCCTAAAACCAAAGAAGGATATTACTACCGTCAA
GTCTTTGAACGCCATTACCCAGGCCGGGCTGACTGGCTGAGCCATTACTGGATGCCCAAG
TGGATCAATGCCACTGACCCTTCTGCCCGCACGCTGACCCACTACAAGTCAGCTGTCAAA
GCTTAG

# Metabolic_Enzyme_32_GenBank_ID_Gene:
M27396

# Metabolic_Enzyme_32_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_32_Locus:
7q21.3

# Metabolic_Enzyme_32_SNPs:
rs1049674; rs6465630; rs7800135; rs4727378; rs7790127; rs11486966; rs11771498; rs17345759; rs17169191; rs3735557; rs11767463; rs17169211; rs17169200; rs3832527; rs17169208; rs2237287; rs7810919; rs7781469; rs10253639; rs12704947; rs7792744; rs1017070; rs7811643; rs2074891; rs7797354; rs2394741; rs4729386; rs4727377; rs17169185; rs4729388; rs17279084; rs2237289; rs17344752; rs12113193; rs4568556; rs1986082; rs10486011; rs10263979; rs2302088; rs11768092; rs13239311; rs10278321; rs17169184; rs7779490; rs12669125; rs4634561; rs17345286; rs7810492; rs17131823; rs11773753; rs4729387; rs17169186; rs11976728; rs1974562; rs3757674; rs10447748; rs3757676; rs3757675; rs17169214; rs7803055; rs12670261; rs12672215; rs13224424; rs2070159; rs11554428; rs3179866; rs1803163; rs11554429; rs11554431; rs1049677; rs3735556; rs34050735; rs11554430; rs35467050; rs34856818; rs3832526; rs13227174; rs34170799; rs28525152; rs10261245; rs6959868; rs28505181; rs36063366; rs13437661; rs10231594; rs35910902; rs28393117; rs13240259; rs28681292; rs41278833; rs2237288; rs12704948; rs13227443; rs41278827; rs10281896; rs28576085; rs10277835; rs36021744; rs13227408; rs41278830; rs10261265; rs41278824; rs13227432; rs35525774; rs12671902; rs13227317; rs13227319; rs34781568; rs13235208; rs35358974; rs35190368; rs34980123; rs28568790; rs13237150; rs36101543; rs36145892; rs13311082; rs12668015; rs28675065; rs35939272; rs34857173; rs10486009; rs10486010; rs11975817; rs13230541; rs2530121; rs6966699; rs7798362; rs7800746; rs9641216

# Metabolic_Enzyme_32_General_References:
2886907; 2565875; 12853948; 3470743; 2569668; 2564390; 2573597

# Metabolic_Enzyme_32_References:
Not Available

# Metabolic_Enzyme_33_ID:
5676

# Metabolic_Enzyme_33_Name:
Adenine phosphoribosyltransferase

# Metabolic_Enzyme_33_Synonyms:
APRT

# Metabolic_Enzyme_33_Gene_Name:
APRT

# Metabolic_Enzyme_33_Protein_Sequence:
>Adenine phosphoribosyltransferase
MADSELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDY
IAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTLWASYSLEYGKAELEIQKDALEPG
QRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSLKGREKLAPVPFFSLLQYE


# Metabolic_Enzyme_33_Number_of_Residues:
180

# Metabolic_Enzyme_33_Molecular_Weight:
19608

# Metabolic_Enzyme_33_Theoretical_pI:
5.82

# Metabolic_Enzyme_33_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
Function:  adenine phosphoribosyltransferase activity
 ||
>>>
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  purine base metabolism
Process:  purine base salvage
Process:  adenine salvage
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_33_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_33_Specific_Function:
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

# Metabolic_Enzyme_33_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_33_Reaction:
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_33_Pfam_Domain_Function:
PF00156:Pribosyltran

# Metabolic_Enzyme_33_Signals:
None

# Metabolic_Enzyme_33_Transmembrane_Regions:
None

# Metabolic_Enzyme_33_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_33_EC_Link:
EC 2.4.2.7

# Metabolic_Enzyme_33_GenBank_ID_Protein:
28819

# Metabolic_Enzyme_33_SwissProt_ID:
APT_HUMAN (P07741)

# Metabolic_Enzyme_33_swissprot_Name:
Not Available

# Metabolic_Enzyme_33_Genecard_id:
APRT

# Metabolic_Enzyme_33_Geneatlas_id:
APRT

# Metabolic_Enzyme_33_hgnc_id:
HGNC:626

# Metabolic_Enzyme_33_PDB_ID:
1ORE

# Metabolic_Enzyme_33_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_33_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_33_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_33_Gene_Sequence:
>543 bp
ATGGCCGACTCCGAGCTGCAGCTGGTTGAGCAGCGGATCCGCAGCTTCCCCGACTTCCCC
ACCCCAGGCGTGGTATTCAGGGACATCTCGCCCGTCCTGAAGGACCCCGCCTCCTTCCGC
GCCGCCATCGGCCTCCTGGCGCGACACCTGAAGGCGACCCACGGGGGCCGCATCGACTAC
ATCGCAGGCCTAGACTCCCGAGGCTTCCTCTTTGGCCCCTCCCTGGCCCAGGAGCTTGGA
CTGGGCTGCGTGCTCATCCGAAAGCGGGGGAAGCTGCCAGGCCCCACTCTGTGGGCCTCC
TATTCCCTGGAGTACGGGAAGGCTGAGCTGGAGATTCAGAAAGACGCCCTGGAGCCAGGA
CAGAGGGTGGTCGTCGTGGATGATCTGCTGGCCACTGGTGGAACCATGAACGCTGCCTGT
GAGCTGCTGGGCCGCCTGCAGGCTGAGGTCCTGGAGTGCGTGAGCCTGGTGGAGCTGACC
TCGCTTAAGGGCAGGGAGAAGCTGGCACCTGTACCCTTCTTCTCTCTCCTGCAGTATGAG
TGA

# Metabolic_Enzyme_33_GenBank_ID_Gene:
Y00486

# Metabolic_Enzyme_33_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_33_Locus:
16q24

# Metabolic_Enzyme_33_SNPs:
rs8191472; rs8191473; rs2242172; rs8191478; rs8191483; rs3214057; rs8191477; rs8191489; rs8191488; rs8191480; rs8191492; rs2242173; rs8191470; rs8191487; rs8191484; rs8191493; rs8191475; rs8191471; rs537641; rs3826075; rs564235; rs535070; rs8191463; rs3759950; rs541276; rs3759952; rs3759951; rs8191468; rs8191460; rs8191465; rs3826074; rs8191464; rs8191469; rs8191466; rs8191461; rs8191458; rs8191494; rs28999113; rs35148077; rs35095508; rs3169258; rs2911456; rs34926513; rs8191476; rs8191491; rs8191482; rs8191495; rs8191486; rs8191481; rs8191479; rs8191474; rs8191485; rs8191490; rs8191457; rs35132384; rs8191459; rs12929472; rs28712013; rs12929307; rs8191467; rs11076715; rs11076716; rs11076718; rs1141390; rs11640595; rs12932340; rs12935469; rs15829; rs1799825; rs1834065; rs2070256; rs2303271; rs2303272; rs2303273; rs3177509; rs3218720; rs3218721; rs3218722; rs3218723; rs3218724; rs3218725; rs3218726; rs3218727; rs3218728; rs3218729; rs3218730; rs3743548; rs3784890; rs3826065; rs3826066; rs3826067; rs3826068; rs3826069; rs3826070; rs3826071; rs4356464; rs4503779; rs4695; rs475667; rs480727; rs507329; rs510862; rs550269; rs555812; rs559678; rs565211; rs572275; rs8059203; rs8191502; rs8191504; rs8191509

# Metabolic_Enzyme_33_General_References:
3684585; 3554238; 3531209; 12665801; 1746557; 7915931; 3680503; 3343350; 1353080; 11243733

# Metabolic_Enzyme_33_References:
Not Available

# Metabolic_Enzyme_34_ID:
5856

# Metabolic_Enzyme_34_Name:
Ubiquitin-conjugating enzyme E2 E2

# Metabolic_Enzyme_34_Synonyms:
Ubiquitin-protein ligase E2; Ubiquitin carrier protein E2; UbcH8

# Metabolic_Enzyme_34_Gene_Name:
UBE2E2

# Metabolic_Enzyme_34_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 E2
MSTEAQRVDDSPSTSGGSSDGDQRESVQQEPEREQVQPKKKEGKISSKTAAKLSTSAKRI
QKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSPDYPFKPPK
VTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQ
YMTNRAEHDRMARQWTKRYAT

# Metabolic_Enzyme_34_Number_of_Residues:
201

# Metabolic_Enzyme_34_Molecular_Weight:
22255

# Metabolic_Enzyme_34_Theoretical_pI:
7.84

# Metabolic_Enzyme_34_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_34_General_Function:
Not Available

# Metabolic_Enzyme_34_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins (Probable)

# Metabolic_Enzyme_34_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_34_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_34_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_34_Signals:
None

# Metabolic_Enzyme_34_Transmembrane_Regions:
None

# Metabolic_Enzyme_34_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_34_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_34_GenBank_ID_Protein:
16553859

# Metabolic_Enzyme_34_SwissProt_ID:
UB2E2_HUMAN (Q96LR5)

# Metabolic_Enzyme_34_swissprot_Name:
Not Available

# Metabolic_Enzyme_34_Genecard_id:
UBE2E2

# Metabolic_Enzyme_34_Geneatlas_id:
UBE2E2

# Metabolic_Enzyme_34_hgnc_id:
HGNC:12478

# Metabolic_Enzyme_34_PDB_ID:
Not Available

# Metabolic_Enzyme_34_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_34_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_34_Subcellular_Location:
Not Available

# Metabolic_Enzyme_34_Gene_Sequence:
>606 bp
ATGTCCACTGAGGCACAAAGAGTTGATGACAGTCCAAGCACTAGTGGAGGAAGTTCCGAT
GGAGATCAACGTGAAAGTGTTCAGCAAGAACCAGAAAGAGAACAAGTTCAGCCCAAGAAA
AAGGAGGGAAAAATATCCAGCAAAACCGCTGCTAAATTGTCAACTAGTGCTAAAAGAATT
CAGAAGGAACTTGCAGAAATCACATTGGACCCTCCTCCCAACTGTAGTGCTGGACCCAAA
GGAGACAACATTTATGAATGGAGGTCAACTATATTGGGACCCCCAGGATCTGTCTATGAA
GGAGGGGTGTTCTTTCTTGACATTACCTTTTCACCAGACTATCCGTTTAAACCCCCTAAG
GTTACCTTCCGAACAAGAATCTATCACTGTAATATTAACAGCCAAGGTGTGATCTGTCTG
GACATCTTAAAGGACAACTGGAGTCCGGCTTTAACTATTTCTAAAGTTCTCCTCTCCATC
TGCTCACTTCTTACAGATTGCAACCCTGCTGACCCTCTGGTGGGCAGCATCGCCACACAG
TACATGACCAACAGAGCAGAGCATGACCGGATGGCCAGACAGTGGACCAAGCGGTACGCC
ACATAG

# Metabolic_Enzyme_34_GenBank_ID_Gene:
AK057886

# Metabolic_Enzyme_34_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_34_Locus:
3p24.2

# Metabolic_Enzyme_34_SNPs:
rs1552931; rs9848077; rs4858483; rs1498809; rs3111311; rs2132148; rs778501; rs1874913; rs1973400; rs1495135; rs778524; rs952134; rs3111310; rs2047339; rs903519; rs704533; rs778503; rs778522; rs778489; rs778459; rs2036226; rs778466; rs1692619; rs1353322; rs778514; rs1391756; rs2173460; rs6795968; rs4241511; rs7629327; rs4858506; rs6780388; rs4858065; rs6784771; rs9814419; rs1495131; rs1692620; rs12330479; rs2359763; rs11720461; rs903520; rs13064035; rs7612463; rs778520; rs1995175; rs9836135; rs778468; rs1463835; rs1692617; rs6550761; rs1692622; rs6796840; rs1498812; rs2173058; rs4858502; rs875443; rs778500; rs7640458; rs11708160; rs6808488; rs2172828; rs7634565; rs9809176; rs7613969; rs6792370; rs7641764; rs4858062; rs1495133; rs1695203; rs778462; rs9847027; rs2359759; rs7617072; rs2884731; rs6804123; rs9826647; rs11916411; rs9880889; rs4858507; rs778486; rs4858505; rs903518; rs9757330; rs6780787; rs1985664; rs6769173; rs6767599; rs778476; rs1692649; rs1552930; rs6780723; rs3817002; rs7636536; rs11711072; rs6808513; rs4858501; rs2055154; rs11926646; rs778517; rs9869171; rs778527; rs4327331; rs9310716; rs9873329; rs9821419; rs778471; rs6797907; rs7609845; rs9826877; rs7640308; rs1011754; rs6775907; rs9812300; rs6776424; rs7429470; rs778508; rs9758590; rs778494; rs1692646; rs2132145; rs6806387; rs4858504; rs4858484; rs1695183; rs7627380; rs4340647; rs801277; rs6550756; rs9874082; rs778521; rs778470; rs9848331; rs4384902; rs6775891; rs3104243; rs13081371; rs7628949; rs778525; rs6792462; rs9310715; rs1498811; rs778515; rs7636705; rs6763535; rs6805889; rs12715048; rs9853489; rs2173461; rs778460; rs9859651; rs6771206; rs4858077; rs4858074; rs2133331; rs2055307; rs11715035; rs9825835; rs11129112; rs6799234; rs7617659; rs1463836; rs6799861; rs4858496; rs6807390; rs7610906; rs1495134; rs2055156; rs778483; rs1908475; rs12330262; rs2359637; rs13323077; rs778523; rs6775232; rs4858508; rs718331; rs12486880; rs2047340; rs9857217; rs17345745; rs778485; rs778461; rs1695181; rs2359638; rs13063986; rs6802465; rs13074192; rs9819788; rs778496; rs6800822; rs10510537; rs1027379; rs11918529; rs2359766; rs9864908; rs9830388; rs11711630; rs9847958; rs6798328; rs4858499; rs6798153; rs11922172; rs4858069; rs13087234; rs9841308; rs778457; rs1695205; rs778484; rs2201481; rs9856169; rs11914363; rs12636682; rs7631334; rs17012905; rs778472; rs11708040; rs6763329; rs778492; rs716456; rs11922562; rs6550765; rs12634459; rs778469; rs11921580; rs10451986; rs6550760; rs11926494; rs13093140; rs6550759; rs2132144; rs11926217; rs12637722; rs11129114; rs2036042; rs12715046; rs9877182; rs2201484; rs6804201; rs778511; rs9862734; rs6762615; rs7645209; rs6770091; rs778507; rs2173057; rs1692652; rs1695170; rs1995174; rs11129120; rs7641437; rs6550755; rs13098494; rs9825778; rs2132149; rs11712500; rs2359761; rs17013383; rs1695188; rs6797467; rs2359765; rs17401815; rs6771053; rs778499; rs4368441; rs1692612; rs1013460; rs6774214; rs6550751; rs1874235; rs9844723; rs778510; rs10510539; rs17194786; rs17402378; rs778480; rs13321359; rs6788900; rs17013390; rs4858498; rs778475; rs17013457; rs1826847; rs11713090; rs9873317; rs9830742; rs17013152; rs6766166; rs17342904; rs704534; rs9836574; rs11713392; rs778487; rs6550748; rs9865602; rs778516; rs2884787; rs1695171; rs6790185; rs7646028; rs7644666; rs1874503; rs6786085; rs13095887; rs11707450; rs778464; rs9854590; rs4858497; rs17012812; rs7613091; rs9839738; rs2055155; rs1692651; rs4858500; rs9852053; rs13326048; rs4399836; rs9883870; rs923996; rs6790327; rs7627525; rs1692647; rs7646541; rs4858492; rs11712582; rs4642064; rs6792915; rs7613733; rs9816895; rs778493; rs4999998; rs10510538; rs13087861; rs4858513; rs7610971; rs931609; rs9861614; rs11718111; rs6782079; rs9631541; rs778467; rs6550752; rs2101811; rs11715841; rs2132146; rs6784195; rs9873979; rs17012869; rs7638278; rs11715107; rs1496653; rs17342980; rs10510536; rs2132147; rs9840808; rs17012959; rs12629848; rs6763074; rs17012829; rs1390083; rs13062101; rs9849176; rs7617725; rs7635784; rs778497; rs13319402; rs6550758; rs778490; rs6764047; rs11129116; rs9815299; rs7634117; rs9854488; rs17013322; rs9681506; rs12493361; rs9846398; rs9713229; rs4858512; rs7630344; rs7636532; rs6795492; rs9681372; rs9875521; rs6799132; rs17013268; rs11916447; rs13082311; rs4858063; rs716457; rs17013412; rs778473; rs7621680; rs11708176; rs9822422; rs13092830; rs2359755; rs13062360; rs9820922; rs17012861; rs778513; rs6550754; rs9840017; rs9832340; rs13066741; rs17343818; rs17013099; rs9810378; rs12490726; rs7644280; rs17013266; rs9853736; rs17013128; rs17013344; rs7639224; rs12715047; rs12637498; rs4858495; rs17013439; rs9873147; rs12633613; rs13073761; rs4578972; rs5023615; rs13072325; rs9835324; rs17013406; rs9631544; rs1695180; rs1695185; rs9844558; rs9853847; rs2036045; rs6795583; rs1532355; rs9882384; rs9830392; rs9879132; rs12630883; rs17012998; rs12630765; rs3104242; rs13100499; rs17013348; rs4538320; rs13063185; rs9809364; rs17013003; rs13090335; rs13089963; rs17013425; rs17012819; rs17013320; rs4858510; rs12630776; rs17194751; rs1874234; rs17013433; rs4858064; rs7624969; rs1908772; rs9816634; rs1692621; rs9874822; rs9824359; rs13094957; rs9840820; rs4858070; rs17013107; rs9829711; rs12386394; rs12497974; rs1542802; rs17013429; rs17013241; rs11715736; rs9848652; rs17013035; rs6807788; rs9841123; rs999764; rs17013245; rs11717397; rs7614195; rs4858515; rs11719401; rs13060251; rs17013356; rs6802488; rs13060112; rs9821681; rs7632099; rs17013029; rs7642713; rs11129113; rs1692648; rs778465; rs7643705; rs17013125; rs17012972; rs3111309; rs12106681; rs17341838; rs17013329; rs7374774; rs9849679; rs6550746; rs4858491; rs9815921; rs17405137; rs1874502; rs17012927; rs13084870; rs778463; rs13090303; rs7628372; rs778458; rs13087416; rs11708117; rs6767954; rs13087563; rs9875910; rs17012823; rs7632814; rs9845536; rs4289304; rs6776770; rs9881808; rs17012991; rs4581996; rs9845372; rs9845340; rs17013009; rs7648425; rs7374592; rs17401836; rs17012988; rs17081034; rs1908773; rs13095736; rs17012844; rs6780897; rs9843539; rs13067919; rs17012897; rs11920019; rs4293660; rs6800930; rs17013409; rs11712991; rs17013219; rs13076527; rs4325868; rs35024744; rs17403650; rs12496355; rs7649682; rs17012966; rs12635274; rs6795584; rs778491; rs7620266; rs9861803; rs13084327; rs9826089; rs35892300; rs1695192; rs2133330; rs17013116; rs4314113; rs9863465; rs778519; rs9879217; rs13325204; rs7652287; rs13065375; rs1027380; rs9681373; rs778498; rs9836787; rs7430428; rs17013333; rs34504120; rs9854148; rs7614667; rs9845368; rs9828922; rs13314364; rs12715045; rs6550747; rs2055310; rs9831159; rs17013104; rs17411757; rs9862557; rs4858493; rs17013314; rs17012969; rs17013049; rs17012852; rs11708225; rs4293659; rs17013393; rs17013286; rs4858509; rs11129119; rs4858490; rs778506; rs2359760; rs7634699; rs17013023; rs17012834; rs7632520; rs6795043; rs13083654; rs9310718; rs13087238; rs778502; rs13070136; rs4858489; rs17013346; rs778488; rs11712012; rs17013026; rs6799167; rs17013422; rs4334589; rs12638508; rs704535; rs9823684; rs11711549; rs17013223; rs17012943; rs17404982; rs13067514; rs9942016; rs778518; rs17029562; rs1390084; rs17013398; rs12630773; rs6796927; rs17342342; rs17013216; rs12636299; rs7613185; rs13085173; rs4858066; rs4858485; rs9859244; rs9823960; rs13316118; rs11915691; rs12185989; rs3104244; rs1695200; rs2036044; rs2359768; rs9831176; rs6801824; rs9849424; rs7612666; rs778505; rs7636683; rs6778478; rs9990072; rs1692650; rs9848389; rs1007332; rs17013418; rs9819566; rs4241512; rs13096187; rs7651175; rs7643270; rs4574222; rs1695172; rs13063451; rs6762546; rs7627151; rs778526; rs9809246; rs7631705; rs11554196; rs2055157; rs6550745; rs35744259; rs34801964; rs34655379; rs34513914; rs34004449; rs35559434; rs13067453; rs7645478; rs13080824; rs34019786; rs13100986; rs9835256; rs28756798; rs6774590; rs13099586; rs34294210; rs35917039; rs34805565; rs13084953; rs4553929; rs35346188; rs35288442; rs35613382; rs34927279; rs36066660; rs35067315; rs35273607; rs34171096; rs6766072; rs28564523; rs35241601; rs10627218; rs778504; rs35281456; rs34644259; rs35994150; rs34882744; rs28370926; rs2359762; rs34972244; rs4858071; rs13059557; rs34514727; rs1495132; rs5847231; rs2133332; rs34732257; rs13091634; rs34740022; rs3059396; rs13076847; rs11719751; rs10692605; rs34969537; rs36182019; rs11437235; rs34225647; rs6807859; rs34311158; rs36143719; rs34135249; rs9828660; rs34447431; rs34029414; rs13076672; rs10703250; rs11399749; rs13315798; rs13323100; rs34248315; rs4858073; rs34339205; rs11356321; rs34758087; rs5847226; rs6774574; rs34322396; rs10704031; rs778479; rs35156003; rs10630330; rs34619482; rs6779406; rs10562289; rs2201485; rs2036227; rs28631180; rs9841336; rs35339492; rs35209889; rs35096750; rs28367247; rs35405803; rs34067122; rs35314441; rs4488778; rs35236373; rs34004175; rs13064211; rs9810035; rs36150838; rs35320722; rs35169377; rs11397342; rs10704606; rs11425389; rs13100962; rs35603984; rs1908476; rs34258016; rs10559253; rs9878638; rs6765542; rs13065734; rs778495; rs35245309; rs1845901; rs13084987; rs35963028; rs7432884; rs34532662; rs35152860; rs13099582; rs35016740; rs11442997; rs1973399; rs35401876; rs4858075; rs9866739; rs35743404; rs6774928; rs3086989; rs7622784; rs34827773; rs5847239; rs7628003; rs34090967; rs13063813; rs9865397; rs9839409; rs34013055; rs11707094; rs9755356; rs28897461; rs36174165; rs35813986; rs34111484; rs1845899; rs7628135; rs11928344; rs11718082; rs35230557; rs11333992; rs34425323; rs2884789; rs13067287; rs7432467; rs34199335; rs7635882; rs6782723; rs3086987; rs9842035; rs2055308; rs11456761; rs34011862; rs11715598; rs35179250; rs35060672; rs6805391; rs35177750; rs11347961; rs1967172; rs34164749; rs13077333; rs36123979; rs11381346; rs28805096; rs9863419; rs12639123; rs34108997; rs35383024; rs35811102; rs11713457; rs11391548; rs13065646; rs34224623; rs7612874; rs9820931; rs35334059; rs1995173; rs36063633; rs36073188; rs12108063; rs35702053; rs7614926; rs7428484; rs34099028; rs35990123; rs724020; rs35778452; rs12631216; rs13096102; rs35136459; rs11447339; rs34368478; rs35778968; rs13098798; rs12634773; rs36183743; rs35074611; rs34916096; rs7611684; rs13072930; rs7611624; rs35351742; rs35883244; rs34830837; rs13072992; rs35027557; rs13085266; rs11354616; rs12496983; rs34810863; rs4858072; rs9842159; rs35413534; rs34713363; rs778509; rs4858487; rs35408638; rs5847225; rs5847232; rs11705812; rs9882514; rs9815359; rs13083473; rs34983674; rs9857085; rs6774185; rs36140837; rs35266274; rs34371006; rs6790215; rs778481; rs36086737; rs11372402; rs12488422; rs6795813; rs11308326; rs13080837; rs36060079; rs11713613; rs35901544; rs34760619; rs13095960; rs34057009; rs35381236; rs4599240; rs35485787; rs778512; rs13083617; rs35161626; rs35066637; rs34317095; rs34765409; rs34476802; rs9827507; rs13062619; rs13087203; rs983288; rs28835332; rs11916781; rs34755696; rs34262865; rs7611132; rs9855653; rs10578696; rs6788095; rs7639266; rs6769951; rs34080387; rs10610153; rs34954186; rs1617948; rs35190363; rs4858516; rs36021750; rs13090125; rs36093333; rs35657558; rs34459823; rs9757785; rs34928302; rs35420157; rs35817947; rs35063383; rs35021696; rs35907941; rs11359887; rs9866889; rs1532356; rs875442; rs34549973; rs3087043; rs4399835; rs1498813; rs34880366; rs35928592; rs35028631; rs13064903; rs34138117; rs10662592; rs9874519; rs13095737; rs11384608; rs34843352; rs36173426; rs34275104; rs36044544; rs36041959; rs13066171; rs9883963; rs35218978; rs36124326; rs5847233; rs6778020; rs2055309; rs35988401; rs4858068; rs35121170; rs13093554; rs35326512; rs11445285; rs11360897; rs36132862; rs6774454; rs9834737; rs2088129; rs9829336; rs13076699; rs34439066; rs11924465; rs9829861; rs1498810; rs34296828; rs36183485; rs4025924; rs34161839; rs28597758; rs34708529; rs6774587; rs11357167; rs34356234; rs4524226; rs7637485; rs13083439; rs4858511; rs13100605; rs11392947; rs9809298; rs12638194; rs35587093; rs35455231; rs778478; rs36037043; rs34317788; rs34873925; rs11320868; rs13324677; rs35156717; rs9810575; rs4361229; rs34284238; rs9821101; rs13078970; rs11333459; rs35038477; rs2220886; rs6773311; rs10717256; rs7618910; rs1994953; rs5847228; rs34255787; rs13068781; rs11457219; rs28412415; rs34410150; rs7612812; rs35282362; rs35360888; rs35067578; rs28408542; rs34541947; rs35325265; rs923995; rs13319311; rs4858488; rs34214070; rs13064776; rs34208918; rs13075300; rs13096458; rs13069028; rs9822891; rs13067459; rs1553131; rs11429585; rs9830853; rs35587590; rs34064548; rs11352255; rs13099381; rs4858078; rs7622178; rs13059155; rs13067927; rs35439686; rs28871023; rs13080401; rs13080261; rs35799553; rs13067463; rs5847236; rs12488524; rs34883078; rs2201482; rs11708887; rs13067292; rs9829577; rs36160278; rs34259979; rs6768277; rs34141165; rs6804376; rs2036043; rs10620901; rs35712816; rs34578427; rs2047338; rs7634494; rs10534830; rs34710747; rs35305944; rs9845888; rs35098118; rs13097879; rs13323350; rs13076490; rs41380744; rs13072903; rs9755698; rs34495480; rs34370439; rs34474714; rs28641973; rs34968174; rs35194124; rs3086984; rs9840015; rs7646505; rs11381775; rs13063183; rs34134134; rs5847234; rs35708850; rs9837894; rs35442948; rs34443476; rs36136020; rs11328464; rs2201483; rs9832647; rs7622913; rs35497505; rs13076412; rs35833677; rs35966355; rs13088756; rs35443771; rs12054273; rs34377610; rs13073593; rs9840130; rs2036229; rs778482; rs36118618; rs4476456; rs35513866; rs34532882; rs13073524; rs12638406; rs11406000; rs9840140; rs34899111; rs6781388; rs7653868; rs11712656; rs35700342; rs1692645; rs4327332; rs11352500; rs6801946; rs35038414; rs778477; rs4025942; rs12485849; rs17402608; rs34928966; rs35287004; rs35902312; rs35903137; rs13067467; rs35323293; rs34376193; rs11433089; rs35513038; rs34051258; rs13067920; rs34825213; rs34680912; rs34525850; rs2359754; rs1695182; rs34047841; rs34305655; rs35788274; rs28582435; rs13067297; rs28842243; rs34584255; rs35513677; rs9811442; rs34564428; rs36016917; rs11433498; rs1692638; rs9841518; rs35403338; rs13100586; rs5019982; rs35538160; rs6769959; rs34011881; rs35778846; rs13065739; rs34474308; rs34962134; rs28656359; rs35220572; rs12638196; rs7614862; rs4513393; rs28787705; rs34644980; rs5847230; rs34528386; rs34646795; rs34830958; rs34258354; rs36004369; rs28567933; rs34896901; rs35795978; rs36082634; rs6765562; rs10700726; rs35105861; rs35084497; rs34775715; rs35614844; rs35347265; rs13071171; rs35003468; rs34334389; rs34087203; rs35449120; rs13085800; rs34528594; rs9841944; rs10428163; rs36173746; rs35402533; rs9868679; rs35163126; rs10662118; rs6765758; rs34743949; rs13086699; rs13067621; rs35776486; rs5847229; rs34362283; rs4558694; rs7429584; rs35869522; rs1695191; rs12490674; rs34036254; rs35240920; rs10701454; rs7638405; rs11349385; rs35762193; rs34536134; rs35404470; rs10212447; rs34239585; rs41400550; rs11401214; rs9867046; rs13088503; rs36005105; rs13101148; rs6764347; rs36123653; rs11456309; rs13067462; rs11299451; rs9842014; rs13073294; rs35322237; rs35802594; rs11721206; rs4072269; rs4361228; rs2088581; rs4858503; rs9845667; rs12632993; rs34367049; rs1054048; rs5847237; rs13076698; rs809640; rs13091625; rs9755696; rs34919006; rs13084967; rs12498004; rs5847235; rs11363428; rs2017065; rs9873929; rs35102034; rs35404820; rs4568058; rs35806683; rs7614479; rs35458447; rs11274063; rs34402532; rs5847240; rs4858076; rs36174845; rs11369768; rs2036228; rs35055753; rs12488059; rs1692614; rs34421575; rs7624174; rs10704575; rs13090633; rs5847238; rs12489408; rs11706072; rs10663571; rs10718748; rs13089479; rs35755640; rs13084250; rs35649850; rs34743793; rs9826103; rs1845900; rs4635650; rs4405859; rs17013336; rs4318497; rs35922435; rs11276620; rs1695197; rs35961001; rs11348019; rs10662177; rs35059447; rs35975795; rs34120479; rs34970044; rs11391624; rs13326380; rs35054154; rs9822244; rs35763885; rs9862673; rs35572661; rs13080692; rs10682310; rs13059775; rs34916962; rs10575820; rs778474; rs12632777; rs28548892; rs11422553; rs11456235; rs35072406; rs7628132; rs9870906; rs34804976; rs11705847; rs35630756; rs9861406; rs35982877; rs35530129; rs6550757; rs35954718; rs35646138; rs4383456; rs34229526; rs12637703; rs35902301; rs7429529; rs34894979; rs13073916; rs35294789; rs2172827; rs28889973; rs13070865; rs6769167; rs13096103; rs35306746; rs35352848; rs11915870; rs35200912; rs35093619; rs34599085; rs6786467; rs34672958; rs36078559; rs36079547; rs12487364; rs34139654; rs35155584; rs35890221; rs34304041; rs10049448; rs1032499; rs1032500; rs1032501; rs10440129; rs11706875; rs11717508; rs11914576; rs11917849; rs11919065; rs13325299; rs1495130; rs17012800; rs2291720; rs34970845; rs4324429; rs4383458; rs4456808; rs4484143; rs6550767; rs7431560; rs7624207; rs7627325; rs7648443; rs7649176; rs7651893; rs9847733; rs9859515; rs9859950; rs9881332

# Metabolic_Enzyme_34_General_References:
Not Available

# Metabolic_Enzyme_34_References:
Not Available

# Metabolic_Enzyme_35_ID:
5857

# Metabolic_Enzyme_35_Name:
Adenylosuccinate lyase

# Metabolic_Enzyme_35_Synonyms:
Adenylosuccinase; ASL; ASASE

# Metabolic_Enzyme_35_Gene_Name:
ADSL

# Metabolic_Enzyme_35_Protein_Sequence:
>Adenylosuccinate lyase
MAAGGDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDE
QIQEMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTD
LIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLC
MDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITG
QTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMR
SERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISE
GLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGD
NDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKA
ELCL

# Metabolic_Enzyme_35_Number_of_Residues:
484

# Metabolic_Enzyme_35_Molecular_Weight:
54890

# Metabolic_Enzyme_35_Theoretical_pI:
7.12

# Metabolic_Enzyme_35_GO_Classification:
>>>
Function:  lyase activity
Function:  carbon-nitrogen lyase activity
Function:  amidine-lyase activity
Function:  adenylosuccinate lyase activity
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine ribonucleotide biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_35_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_35_Specific_Function:
6-N-(1,2-dicarboxyethyl)AMP = fumarate + AMP

# Metabolic_Enzyme_35_Pathway:
map00230  Purine metabolism;
 map00252  Alanine and aspartate metabolism

# Metabolic_Enzyme_35_Reaction:
(1) N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP; (2) (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

# Metabolic_Enzyme_35_Pfam_Domain_Function:
PF00206:Lyase_1

# Metabolic_Enzyme_35_Signals:
None

# Metabolic_Enzyme_35_Transmembrane_Regions:
None

# Metabolic_Enzyme_35_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_35_EC_Link:
EC 4.3.2.2

# Metabolic_Enzyme_35_GenBank_ID_Protein:
28904

# Metabolic_Enzyme_35_SwissProt_ID:
PUR8_HUMAN (P30566)

# Metabolic_Enzyme_35_swissprot_Name:
Not Available

# Metabolic_Enzyme_35_Genecard_id:
ADSL

# Metabolic_Enzyme_35_Geneatlas_id:
ADSL

# Metabolic_Enzyme_35_hgnc_id:
HGNC:291

# Metabolic_Enzyme_35_PDB_ID:
Not Available

# Metabolic_Enzyme_35_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_35_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_35_Subcellular_Location:
Not Available

# Metabolic_Enzyme_35_Gene_Sequence:
>1455 bp
ATGGCGGCTGGAGGCGATCATGGTTCGCCCGACAGCTACCGCTCACCTCTTGCCTCCCGC
TATGCCAGCCCGGAGATGTGCTTCGTGTTTAGCGACAGGTATAAATTCCGGACATGGCGG
CAGCTGTGGCTGTGGCTGGCGGAGGCCGAGCAGACATTGGGTTTGCCTATCACAGATGAA
CAAATCCAGGAGATGAAATCAAACCTGGAGAACATAGACTTCAAGATGGCAGCTGAGGAA
GAGAAACGTTTACGACATGATGTGATGGCTCACGTGCACACATTTGGCCACTGCTGTCCA
AAAGCTGCAGGCATTATTCACCTTGGTGCTACTTCTTGCTATGTTGGAGACAATACTGAC
TTGATTATTCTTAGAAATGCACTTGACCTGCTTTTGCCAAAGCTTGCCAGAGTGATCTCT
CGGCTTGCCGACTTTGCTAAGGAACGAGCCAGTCTACCCACATTAGGTTTCACACATTTC
CAGCCTGCACAGCTGACCACAGTTGGGAAACGTTGCTGTCTTTGGATTCAGGATCTTTGC
ATGGATCTCCAGAACTTGAAGCGTGTCCGAGATGACCTGCGCTTCCGGGGAGTAAAGGGT
ACCACTGGCACTCAGGCCAGTTTCCTGCAGCTCTTTGAGGGAGATGACCATAAGGTAGAG
CAGCTTGACAAGATGGTGACAGAAAAGGCAGGATTTAAGAGAGCTTTCATCATCACAGGG
CAGACATATACACGAAAAGTGGATATTGAAGTACTGTCTGTGCTGGCTAGCTTGGGGGCA
TCAGTGCACAAGATTTGCACCGACATACGCCTCCTGGCAAACCTCAAGGAGATGGAGGAA
CCCTTTGAAAAACAGCAGATTGGCTCAAGTGCGATGCCATATAAGCGGAATCCCATGCGT
TCAGAACGTTGCTGCAGTCTTGCCCGCCACCTGATGACCCTTGTCATGGACCCGCTACAG
ACAGCATCTGTCCAGTGGTTTGAACGCACACTGGATGATAGTGCCAACCGACGGATCTGT
TTGGCCGAGGCATTTCTTACCGCAGATACTATATTGAATACGCTGCAGAACATTTCTGAA
GGATTGGTCGTGTACCCCAAAGTAATTGAACGGCGCATTCGGCAAGAGCTGCCTTTCATG
GCCACAGAGAACATCATCATGGCCATGGTCAAAGCTGGAGGTAGCCGCCAGGATTGCCAT
GAGAAAATCAGAGTGCTTTCTCAGCAGGCAGCTTCTGTGGTTAAGCAGGAAGGGGGTGAC
AATGACCTCATAGAGCGTATCCAGGTTGATGCCTACTTCAGTCCCATTCACTCCCAGTTG
GATCATTTACTGGATCCTTCTTCTTTCACTGGTCGTGCCTCCCAGCAGGTGCAGAGATTC
TTAGAAGAGGAGGTGTATCCCCTGTTAAAACCATATGAAAGCGTGATGAAGGTGAAAGCA
GAATTATGTCTGTAG

# Metabolic_Enzyme_35_GenBank_ID_Gene:
X65867

# Metabolic_Enzyme_35_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_35_Locus:
22q13.1|22q13.2

# Metabolic_Enzyme_35_SNPs:
rs2068470; rs3788578; rs3788579; rs3788577; rs9611321; rs8135371; rs7291418; rs17001846; rs10854729; rs11913275; rs2280790; rs2075764; rs12160297; rs5757922; rs17001863; rs17001848; rs17001857; rs4321458; rs2006965; rs909669; rs12484610; rs5757921; rs8192461; rs11089991; rs8192457; rs34396910; rs8192454; rs2735668; rs11703124; rs8192453; rs8192458; rs2743718; rs17001854; rs5995848; rs2743725; rs2735660; rs2735669; rs34476033; rs2735672; rs4820411; rs2743716; rs6001886; rs35043528; rs35572733; rs5995847; rs2743723; rs2735665; rs10427931; rs11089990; rs2743721; rs12170384; rs2743728; rs2743719; rs8192455; rs2735667; rs8192460; rs1882824; rs5757924; rs36099663; rs2735663; rs2735673; rs2743717; rs10427911; rs28699192; rs2743726; rs3830737; rs2743724; rs7285719; rs6001887; rs8192452; rs28642715; rs9611322; rs5750935; rs2735664; rs2735666; rs8192459; rs11431892; rs9611323; rs1882823; rs35553188; rs8142978; rs2743729; rs2743722; rs5757923; rs2735661; rs8192456; rs35401769; rs2743727; rs17001850; rs2743720; rs35128658; rs3044501; rs2743731; rs742139; rs2006961; rs909205; rs5995846; rs9607708; rs5757920; rs2743714; rs751367; rs5995845; rs5757918; rs16985898; rs9611320; rs2743732; rs35992774; rs909204; rs11320845; rs2743730; rs2743715; rs10650685; rs5757919; rs2743713; rs12484697; rs4619722; rs5995844; rs6001883; rs6001888; rs9611310; rs9611311; rs9611312; rs9611314; rs9611316; rs9611318; rs9623170

# Metabolic_Enzyme_35_General_References:
10888601; 10591208; 1302001; 9545543; 10090474; 10958654; 12368987

# Metabolic_Enzyme_35_References:
Not Available

# Metabolic_Enzyme_36_ID:
5858

# Metabolic_Enzyme_36_Name:
Adenylate kinase isoenzyme 4, mitochondrial

# Metabolic_Enzyme_36_Synonyms:
Adenylate kinase 3-like 1; ATP-AMP transphosphorylase

# Metabolic_Enzyme_36_Gene_Name:
AK3L1

# Metabolic_Enzyme_36_Protein_Sequence:
>Adenylate kinase isoenzyme 4, mitochondrial
MASKLLRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEK
SLLVPDHVITRLMMSELENRRGQHWLLDGFPRTLGQAEALDKICEVDLVISLNIPFETLK
DRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKP
VIELYKSRGVLHQFSGTETNKIWPYVYTLFSNKITPIQSKEAY

# Metabolic_Enzyme_36_Number_of_Residues:
223

# Metabolic_Enzyme_36_Molecular_Weight:
25268

# Metabolic_Enzyme_36_Theoretical_pI:
8.66

# Metabolic_Enzyme_36_GO_Classification:
>>>
Function:  adenylate kinase activity
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleotide kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_36_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_36_Specific_Function:
ATP + AMP = 2 ADP

# Metabolic_Enzyme_36_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_36_Reaction:
ATP + AMP = 2 ADP

# Metabolic_Enzyme_36_Pfam_Domain_Function:
PF00406:ADK;
PF05191:ADK_lid

# Metabolic_Enzyme_36_Signals:
None

# Metabolic_Enzyme_36_Transmembrane_Regions:
None

# Metabolic_Enzyme_36_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_36_EC_Link:
EC 2.7.4.3

# Metabolic_Enzyme_36_GenBank_ID_Protein:
28577

# Metabolic_Enzyme_36_SwissProt_ID:
KAD4_HUMAN (P27144)

# Metabolic_Enzyme_36_swissprot_Name:
Not Available

# Metabolic_Enzyme_36_Genecard_id:
AK3L1

# Metabolic_Enzyme_36_Geneatlas_id:
AK3L1

# Metabolic_Enzyme_36_hgnc_id:
HGNC:363

# Metabolic_Enzyme_36_PDB_ID:
Not Available

# Metabolic_Enzyme_36_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_36_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_36_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_36_Gene_Sequence:
>672 bp
ATGGCTTCCAAACTCCTGCGCGCGGTCATCCTCGGGCCGCCCGGCTCGGGCAAGGGCACC
GTGTGCCAGAGGATCGCCCAGAACTTTGGTCTCCAGCATCTCTCCAGCGGCCACTTCTTG
CGGGAGAACATCAAGGCCAGCACCGAAGTTGGTGAGATGGCAAAGCAGTATATAGAGAAA
AGTCTTTTGGTTCCAGACCATGTGATCACACGCCTAATGATGTCCGAGTTGGAGAACAGG
CGTGGACAGCACTGGCTCCTTGATGGTTTTCCTAGGACATTAGGACAAGCCGAAGCCCTG
GACAAAATCTGTGAAGTGGATCTAGTGATCAGTTTGAATATTCCATTTGAAACACTTAAA
GATCGTCTCAGCCGCCGTTGGATTCACCCTCCTAGCGGAAGGGTATATAACCTGGACTTC
AATCCACCTCATGTACATGGTATTGATGACGTCACTGGTGAACCGTTAGTCCAGCAGGAG
GATGATAAACCCGAAGCAGTTGCTGCCAGGCTAAGACAGTACAAAGACGTGGCAAAGCCA
GTCATTGAATTATACAAGAGCCGAGGAGTGCTCCACCAATTTTCCGGAACGGAGACGAAC
AAAATCTGGCCCTACGTTTACACACTTTTCTCAAACAAGATCACACCTATTCAGTCCAAA
GAAGCATATTGA

# Metabolic_Enzyme_36_GenBank_ID_Gene:
X60673

# Metabolic_Enzyme_36_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_36_Locus:
1p31.3

# Metabolic_Enzyme_36_SNPs:
rs9092; rs2375754; rs4916021; rs2889183; rs4915681; rs12410079; rs12089221; rs12068872; rs10583751; rs5029884; rs35775264; rs10047101; rs10465849; rs10465850; rs1072864; rs10749750; rs10789170; rs10789171; rs10789175; rs10789176; rs10889523; rs10889525; rs10889527; rs10889529; rs1109374; rs11208596; rs11208599; rs11208604; rs11208605; rs11208607; rs11208609; rs11208610; rs11208611; rs1122651; rs1125091; rs11579215; rs11581070; rs11581072; rs11803130; rs11807827; rs12022787; rs12030227; rs12048066; rs12060525; rs12074520; rs12088806; rs12091763; rs12091953; rs12093622; rs12094960; rs12119363; rs12124886; rs12133650; rs12401887; rs12403808; rs12404018; rs12404708; rs12409392; rs12561779; rs12563060; rs12565315; rs12568459; rs12747074; rs1336472; rs1336474; rs13374371; rs1539551; rs1573168; rs17127364; rs17127378; rs17127422; rs17400019; rs1855981; rs1855982; rs1889925; rs1889926; rs1891674; rs2051092; rs2226173; rs2375596; rs2375597; rs2375598; rs2889130; rs34248479; rs35832978; rs3934817; rs4291532; rs4372299; rs4453083; rs4511159; rs4915683; rs4915684; rs4915685; rs4916026; rs4916030; rs4916031; rs4916032; rs6588125; rs6588126; rs6588127; rs6656147; rs6677191; rs6677316; rs6680983; rs6689998; rs6690851; rs6691933; rs6699614; rs6702163; rs6702993; rs6704305; rs7416515; rs7511787; rs7521374; rs7526688; rs7529834; rs7545094; rs7547221; rs7548127; rs7550324; rs7553495; rs955255

# Metabolic_Enzyme_36_General_References:
1639383

# Metabolic_Enzyme_36_References:
Not Available

# Metabolic_Enzyme_37_ID:
5236

# Metabolic_Enzyme_37_Name:
5'(3')-deoxyribonucleotidase, mitochondrial precursor

# Metabolic_Enzyme_37_Synonyms:
5',3'-nucleotidase, mitochondrial; Deoxy-5'-nucleotidase 2; dNT-2

# Metabolic_Enzyme_37_Gene_Name:
NT5M

# Metabolic_Enzyme_37_Protein_Sequence:
>5'3'deoxyribonucleotidase, mitochondrial precursor
MIRLGGWCARRLCSAAVPAGRRGAAGGLGLAGGRALRVLVDMDGVLADFEGGFLRKFRAR
FPDQPFIALEDRRGFWVSEQYGRLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMAS
LQNTDVFICTSPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDI
TGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRPC

# Metabolic_Enzyme_37_Number_of_Residues:
228

# Metabolic_Enzyme_37_Molecular_Weight:
25862

# Metabolic_Enzyme_37_Theoretical_pI:
8.12

# Metabolic_Enzyme_37_GO_Classification:
Not Available

# Metabolic_Enzyme_37_General_Function:
Not Available

# Metabolic_Enzyme_37_Specific_Function:
Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP

# Metabolic_Enzyme_37_Pathway:
Not Available

# Metabolic_Enzyme_37_Reaction:
Not Available

# Metabolic_Enzyme_37_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_37_Signals:
1-15

# Metabolic_Enzyme_37_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_37_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_37_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_37_GenBank_ID_Protein:
9408106

# Metabolic_Enzyme_37_SwissProt_ID:
NT5M_HUMAN (Q9NPB1)

# Metabolic_Enzyme_37_swissprot_Name:
Not Available

# Metabolic_Enzyme_37_Genecard_id:
NT5M

# Metabolic_Enzyme_37_Geneatlas_id:
NT5M

# Metabolic_Enzyme_37_hgnc_id:
HGNC:15769

# Metabolic_Enzyme_37_PDB_ID:
1Q92

# Metabolic_Enzyme_37_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_37_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_37_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_37_Gene_Sequence:
>687 bp
ATGATCCGGCTGGGCGGCTGGTGTGCGCGGCGGCTCTGCAGCGCGGCGGTTCCCGCGGGG
CGGCGCGGGGCGGCGGGCGGGCTGGGCCTGGCGGGAGGCCGCGCCCTACGGGTGCTGGTG
GACATGGACGGCGTGCTGGCTGACTTCGAGGGCGGATTCCTCAGGAAGTTCCGCGCGCGC
TTTCCCGACCAGCCCTTCATCGCGCTGGAGGACCGGCGCGGCTTCTGGGTGTCGGAGCAG
TACGGCCGCCTGCGGCCAGGGCTGAGCGAGAAGGCCATCAGCATTTGGGAGTCAAAGAAT
TTCTTTTTTGAACTTGAGCCTCTGCCAGGGGCCGTGGAAGCTGTCAAGGAGATGGCCAGC
CTACAAAACACTGACGTCTTCATCTGCACAAGCCCCATCAAGATGTTCAAGTACTGTCCC
TATGAGAAGTATGCCTGGGTGGAGAAGTACTTTGGCCCTGACTTTCTGGAGCAGATTGTG
CTGACCAGAGACAAGACCGTGGTCTCTGCTGACCTTCTCATAGACGACCGGCCGGACATC
ACAGGGGCCGAGCCAACCCCCAGCTGGGAGCATGTCCTCTTCACCGCCTGCCACAACCAG
CACCTGCAGCTGCAGCCCCCCCGCCGCAGGCTGCACTCGTGGGCGGACGACTGGAAGGCC
ATTCTGGACAGCAAGCGGCCCTGCTGA

# Metabolic_Enzyme_37_GenBank_ID_Gene:
AJ277557

# Metabolic_Enzyme_37_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_37_Locus:
17p11.2

# Metabolic_Enzyme_37_SNPs:
rs2240876; rs758742; rs1860553; rs242243; rs6502579; rs7223473; rs11078384; rs7226068; rs10468464; rs12948296; rs1860552; rs9912109; rs9898622; rs7211968; rs17726703; rs9914692; rs3785502; rs11867932; rs3785504; rs17726673; rs11654778; rs16942153; rs17726858; rs11078382; rs3826302; rs2064060; rs6502580; rs7217503; rs9912172; rs3785506; rs9908168; rs11652902; rs9902505; rs4985707; rs6502576; rs6502578; rs16961564; rs7210344; rs16961516; rs242242; rs171394; rs12600778; rs9909111; rs7219752; rs6502577; rs12601631; rs11869054; rs17726924; rs9891799; rs11870836; rs11869507; rs11078383; rs4985706; rs7217162; rs9889738; rs9908338; rs7222555; rs9915883; rs7211243; rs9916133; rs9907857; rs9905836; rs11657817; rs9889298; rs7220829; rs9903425; rs9908360; rs9914424; rs9908124; rs11650700; rs11869079; rs7212369; rs9889367; rs7217114; rs9896977; rs9916676; rs16961561; rs12602026; rs9896970; rs9904396; rs9909850; rs10852849; rs11078385; rs6502575; rs242244; rs16961576; rs3203918; rs8082383; rs7212012; rs36114962; rs9889834; rs7226045; rs12602003; rs9894669; rs35712658; rs12941075; rs7210625; rs35320589; rs11655849; rs35470335; rs34668117; rs12943271; rs34446504; rs35945070; rs34219219; rs12951176; rs35554631; rs34408375; rs28825184; rs7218566; rs35917484; rs28880443; rs9904393; rs12601106; rs34579357; rs4985765; rs9907711; rs11343472; rs35579933; rs3087093; rs12951985; rs34993127; rs36088408; rs36091965; rs34100977; rs7220057; rs8080335; rs9901325; rs35720826; rs34886391; rs12949216; rs9898993; rs34121330; rs34513135; rs12936127; rs8067236; rs8081939; rs10617184; rs7211790; rs9914209; rs12951519; rs12603230; rs9913775; rs8068408; rs12452455; rs9901373; rs3063349; rs9913682; rs3785503; rs34156759; rs34776810; rs10574223; rs34836173; rs12951434; rs9709057; rs28813401; rs36146846; rs34709982; rs28616155; rs8082379; rs35267848; rs12951289; rs12948357; rs12950577; rs35861887; rs12948747; rs35096596; rs8080408; rs9898042; rs35930947; rs12948751; rs5741757; rs9889355; rs35575792; rs34018072; rs34407368; rs4985764; rs11395505; rs34676851; rs12951504; rs12950929; rs34025151; rs3837806; rs34247865; rs12946386; rs34209605; rs7219953; rs12951983; rs11400183; rs9912599; rs36056059; rs8071972; rs35039203; rs35326975; rs8071718; rs12946113; rs1009720; rs10852850; rs11078381; rs11078386; rs11871699; rs12450758; rs12451886; rs12452946; rs12602578; rs16961593; rs16961599; rs17648393; rs183596; rs190261; rs2041393; rs2058292; rs2191383; rs242246; rs242247; rs242249; rs242250; rs242251; rs624242; rs6502572; rs8067390; rs9892592; rs9899615; rs9905458; rs9909800; rs9914113

# Metabolic_Enzyme_37_General_References:
10899995; 12352955

# Metabolic_Enzyme_37_References:
Not Available

# Metabolic_Enzyme_38_ID:
5859

# Metabolic_Enzyme_38_Name:
Ubiquitin-conjugating enzyme E2 D2

# Metabolic_Enzyme_38_Synonyms:
Ubiquitin-protein ligase D2; Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2-17 kDa 2; E2(17KB 2

# Metabolic_Enzyme_38_Gene_Name:
UBE2D2

# Metabolic_Enzyme_38_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 D2
MALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDY
PFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLV
PEIARIYKTDREKYNRIAREWTQKYAM

# Metabolic_Enzyme_38_Number_of_Residues:
147

# Metabolic_Enzyme_38_Molecular_Weight:
16735

# Metabolic_Enzyme_38_Theoretical_pI:
7.96

# Metabolic_Enzyme_38_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_38_General_Function:
Not Available

# Metabolic_Enzyme_38_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53

# Metabolic_Enzyme_38_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_38_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_38_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_38_Signals:
None

# Metabolic_Enzyme_38_Transmembrane_Regions:
None

# Metabolic_Enzyme_38_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_38_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_38_GenBank_ID_Protein:
1145689

# Metabolic_Enzyme_38_SwissProt_ID:
UB2D2_HUMAN (P62837)

# Metabolic_Enzyme_38_swissprot_Name:
Not Available

# Metabolic_Enzyme_38_Genecard_id:
UBE2D2

# Metabolic_Enzyme_38_Geneatlas_id:
UBE2D2

# Metabolic_Enzyme_38_hgnc_id:
HGNC:12475

# Metabolic_Enzyme_38_PDB_ID:
1UR6

# Metabolic_Enzyme_38_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_38_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_38_Subcellular_Location:
Not Available

# Metabolic_Enzyme_38_Gene_Sequence:
>444 bp
ATGGCTCTGAAGAGAATCCACAAGGAATTGAATGATCTGGCACGGGACCCTCCAGCACAG
TGTTCAGCAGGTCCTGTTGGAGATGATATGTTCCATTGGCAAGCTACAATAATGGGGCCA
AATGACAGTCCCTATCAGGGTGGAGTATTTTTCTTGACAATTCATTTCCCAACAGATTAC
CCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGT
AATGGCAGCATTTGTCTTGATATTCTACGATCACAGTGGTCTCCAGCACTAACTATTTCA
AAAGTACTCTTGTCCATCTGTTCTCTGTTGTGTGATCCCAATCCAGATGATCCTTTAGTG
CCTGAGATTGCTCGGATCTACAAAACAGATAGAGAAAAGTACAACAGAATAGCTCGGGAA
TGGACTCAGAAGTATGCGATGTAA

# Metabolic_Enzyme_38_GenBank_ID_Gene:
U39317

# Metabolic_Enzyme_38_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_38_Locus:
5q31.2

# Metabolic_Enzyme_38_SNPs:
rs769052; rs355148; rs261534; rs261532; rs355163; rs355161; rs11742182; rs431184; rs355151; rs261530; rs355147; rs11739735; rs355160; rs11745986; rs436308; rs355159; rs10080073; rs13160670; rs432021; rs401870; rs191642; rs355162; rs10041009; rs355158; rs6863230; rs165179; rs356428; rs356427; rs7735780; rs173335; rs403583; rs440662; rs355157; rs446588; rs12522684; rs356426; rs12516628; rs35329113; rs11745287; rs13173105; rs11446242; rs11418234; rs13359150; rs261531; rs34077929; rs34069884; rs35426398; rs35539143; rs166363; rs34197355; rs10070662; rs35586007; rs28829083; rs34181052; rs34848313; rs13340360; rs35460912; rs10051828; rs861110; rs36027909; rs173313; rs355164; rs3052716; rs1053439; rs5871700; rs11425354; rs34582513; rs35656160; rs34558950; rs13187063; rs11399868; rs11748952; rs13171900; rs4912705; rs10642044; rs11960270; rs34037453; rs34066792; rs13360691; rs34697798; rs5871699; rs33998713; rs34262724; rs261533; rs400752; rs35460807; rs35791838; rs34654005; rs13156781; rs34508985; rs34864079; rs35070538; rs10576440; rs35250928; rs34719091; rs35008393; rs10241; rs149308; rs11746982; rs406234; rs13161515; rs34999200; rs11557558; rs10069891; rs35023106; rs10077827; rs34444899; rs4044316; rs824159; rs11167511; rs1132734; rs187780; rs34295586; rs403719; rs10642043; rs35529886; rs169015; rs11957802; rs187144; rs10050552; rs4519969; rs34260351; rs6863764; rs430284; rs34313106; rs11341390; rs10621546; rs165180; rs28666809; rs12518658; rs7734338; rs10065372; rs12520710; rs36025157; rs9324839; rs191643; rs28606386; rs10068179; rs34610126; rs35630520; rs355154; rs622355; rs36010124; rs41391051; rs28402246; rs677275; rs41393145; rs638202; rs3777111; rs34693140; rs355153; rs13159515; rs28492801; rs10056652; rs28477768; rs34687149; rs12653982; rs3777110; rs4044317; rs591830; rs355152; rs655674; rs34199267; rs355156; rs355146; rs7729523; rs13361425; rs9324838; rs12652179; rs28622416; rs355155; rs12513420; rs7442849; rs181494; rs11421613; rs34150521; rs12517275; rs13178050; rs13357137; rs261537; rs356456; rs356458; rs356459; rs356460; rs356461; rs356462; rs356463; rs4912730; rs629831; rs678176; rs7448830

# Metabolic_Enzyme_38_General_References:
8530467; 7724550; 10918611

# Metabolic_Enzyme_38_References:
Not Available

# Metabolic_Enzyme_39_ID:
5860

# Metabolic_Enzyme_39_Name:
DNA ligase 4

# Metabolic_Enzyme_39_Synonyms:
DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4

# Metabolic_Enzyme_39_Gene_Name:
LIG4

# Metabolic_Enzyme_39_Protein_Sequence:
>DNA ligase 4
MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDV
TDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHG
DAGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSA
LEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSDISI
TLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTD
QFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDL
QTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNE
AIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRGGMM
SHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILC
GTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLE
QLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFE
DVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDV
VKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSG
IKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAI
KALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDK
CELQEENQYLI

# Metabolic_Enzyme_39_Number_of_Residues:
911

# Metabolic_Enzyme_39_Molecular_Weight:
103972

# Metabolic_Enzyme_39_Theoretical_pI:
8.04

# Metabolic_Enzyme_39_GO_Classification:
>>>
Function:  DNA ligase (ATP) activity
Function:  nucleic acid binding
Function:  DNA binding
Function:  DNA ligase (ATP) activity
Function:  DNA ligase (ATP) activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  DNA ligase activity
Function:  DNA ligase (ATP) activity
 ||
>>>
Process:  DNA recombination
Process:  DNA repair
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  DNA metabolism
Process:  DNA replication
 ||
>>>
Component:  cell
Component:  intracellular

# Metabolic_Enzyme_39_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_39_Specific_Function:
Efficiently joins single-strand breaks in a double- stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA- dependent protein kinase complex DNA-PK to these DNA ends

# Metabolic_Enzyme_39_Pathway:
Not Available

# Metabolic_Enzyme_39_Reaction:
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m

# Metabolic_Enzyme_39_Pfam_Domain_Function:
PF00533:BRCT;
PF04679:DNA_ligase_A_C;
PF01068:DNA_ligase_A_M;
PF04675:DNA_ligase_A_N

# Metabolic_Enzyme_39_Signals:
None

# Metabolic_Enzyme_39_Transmembrane_Regions:
None

# Metabolic_Enzyme_39_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_39_EC_Link:
EC 6.5.1.1

# Metabolic_Enzyme_39_GenBank_ID_Protein:
860937

# Metabolic_Enzyme_39_SwissProt_ID:
DNL4_HUMAN (P49917)

# Metabolic_Enzyme_39_swissprot_Name:
Not Available

# Metabolic_Enzyme_39_Genecard_id:
LIG4

# Metabolic_Enzyme_39_Geneatlas_id:
LIG4

# Metabolic_Enzyme_39_hgnc_id:
HGNC:6601

# Metabolic_Enzyme_39_PDB_ID:
Not Available

# Metabolic_Enzyme_39_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_39_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_39_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_39_Gene_Sequence:
>2535 bp
ATGAGACTAATTCTTCCTCAGCTAGAAAGAGAGAGAATGGCCTATGGAATTAAAGAAACT
ATGCTTGCTAAGCTTTATATTGAGTTGCTTAATTTACCTAGAGATGGAAAAGATGCCCTC
AAACTTTTAAACTACAGAACACCCACTGGAACTCATGGAGATGCTGGAGACTTTGCAATG
ATTGCATATTTTGTGTTGAAGCCAAGATGTTTACAGAAAGGAAGTTTAACCATACAGCAA
GTAAACGACCTTTTAGACTCAATTGCCAGCAATAATTCTGCTAAAAGAAAAGACCTAATA
AAAAAGAGCCTTCTTCAACTTATAACTCAGAGTTCAGCACTTGAGCAAAAGTGGCTTATA
CGGATGATCATAAAGGATTTAAAGCTTGGTGTTAGTCAGCAAACTATCTTTTCTGTTTTT
CATAATGATGCTGCTGAGTTGCATAATGTCACTACAGATCTGGAAAAAGTCTGTAGGCAA
CTGCATGATCCTTCTGTAGGACTCAGTGATATTTCTATCACTTTATTTTCTGCATCAAAA
CCAATGCTAGCTGCTATTGCAGATATTGAGCACATTGAGAAGGATATGAAACATCAGAGT
TTCTACATAGAAACCAAGCTAGATGGTGAACGTATGCAAATGCACAAAGATGGAGATGTA
TATAAATACTTCTCTCGAAATGGATATAACTACACTGATCAGTTTGGTGCTTCTCCTACT
GAAGGTTCTCTTACCCCATTCATTCATAATGCATTCAAAGCAGATATACAAATCTGTATT
CTTGATGGTGAGATGATGGCCTATAATCCTAATACACAAACTTTCATGCAAAAGGGAACT
AAGTTTGATATTAAAAGAATGGTAGAGGATTCTGATCTGCAAACTTGTTATTGTGTTTTT
GATGTATTGATGGTTAATAATAAAAAGCTAGGGCATGAGACTCTGAGAAAGAGGTATGAG
ATTCTTAGTAGTATTTTTACACCAATTCCAGGTAGAATAGAAATAGTGCAGAAAACACAA
GCTCATACTAAGAATGAAGTAATTGATGCATTGAATGAAGCAATAGATAAAAGAGAAGAG
GGAATTATGGTAAAACAACCTCTATCCATCTACAAGCCAGACAAAAGAGGTGAAGGGTGG
TTAAAAATTAAACCAGAGTATGTCAGTGGACTAATGGATGAATTGGACATTTTAATTGTT
GGAGGATATTGGGGTAAAGGATCACGGGGTGGAATGATGTCTCATTTTCTGTGTGCAGTA
GCAGAGAAGCCCCCTCCTGGTGAGAAGCCATCTGTGTTTCATACTCTCTCTCGTGTTGGG
TCTGGCTGCACCATGAAAGAACTGTATGATCTGGGTTTGAAATTGGCCAAGTATTGGAAG
CCTTTTCATAGAAAAGCTCCACCAAGCAGCATTTTATGTGGAACAGAGAAGCCAGAAGTA
TACATTGAACCTTGTAATTCTGTCATTGTTCAGATTAAAGCAGCAGAGATCGTACCCAGT
GATATGTATAAAACTGGCTGCACCTTGCGTTTTCCACGAATTGAAAAGATAAGAGATGAC
AAGGAGTGGCATGAGTGCATGACCCTGGACGACCTAGAACAACTTAGGGGGAAGGCATCT
GGTAAGCTCGCATCTAAACACCTTTATATAGGTGGTGATGATGAACCACAAGAAAAAAAG
CGGAAAGCTGCCCCAAAGATGAAGAAAGTTATTGGAATTATTGAGCACTTAAAAGCACCT
AACCTTACTAACGTTAACAAAATTTCTAATATATTTGAAGATGTAGAGTTTTGTGTTATG
AGTGGAACAGATAGCCAGCCAAAGCCTGACCTGGAGAACAGAATTGCAGAATTTGGTGGT
TATATAGTACAAAATCCAGGCCCAGACACGTACTGTGTAATTGCAGGGTCTGAGAACATC
AGAGTGAAAAACATAATTTTGTCAAATAAACATGATGTTGTCAAGCCTGCATGGCTTTTA
GAATGTTTTAAGACCAAAAGCTTTGTACCATGGCAGCCTCGCTTTATGATTCATATGTGC
CCATCAACCAAAGAACATTTTGCCCGTGAATATGATTGCTATGGTGATAGTTATTTCATT
GATACAGACTTGAACCAACTGAAGGAAGTATTCTCAGGAATTAAAAATTCTAACGAGCAG
ACTCCTGAAGAAATGGCTTCTCTGATTGCTGATTTAGAATATCGGTATTCCTGGGATTGC
TCTCCTCTCAGTATGTTTCGACGCCACACCGTTTATTTGGACTCGTATGCTGTTATTAAT
GACCTGAGTACCAAAAATGAGGGGACAAGGTTAGCTATTAAAGCCTTGGAGCTTCGGTTT
CATGGAGCAAAAGTAGTTTCTTGTTTAGCTGAGGGAGTGTCTCATGTAATAATTGGGGAA
GATCATAGTCGTGTTGCAGATTTTAAAGCTTTTAGAAGAACTTTTAAGAGAAAGTTTAAA
ATCCTAAAAGAAAGTTGGGTAACTGATTCAATAGACAAGTGTGAATTACAAGAAGAAAAC
CAGTATTTGATTTAA

# Metabolic_Enzyme_39_GenBank_ID_Gene:
X83441

# Metabolic_Enzyme_39_Chromosome_Location:
Chromosome:13

# Metabolic_Enzyme_39_Locus:
13q33-q34

# Metabolic_Enzyme_39_SNPs:
rs1805388; rs2232642; rs1805389; rs2232641; rs2232636; rs2232638; rs1805386; rs2232639; rs3093764; rs3093772; rs3093748; rs10131; rs3093740; rs3093747; rs3093758; rs1805387; rs3093739; rs3093743; rs4987182; rs3093769; rs3093741; rs3093759; rs1805385; rs2232643; rs3093744; rs1805383; rs3093742; rs3093768; rs3093770; rs3093751; rs2232644; rs3093756; rs3093745; rs3093767; rs1805384; rs3093755; rs3093753; rs3093762; rs3093746; rs3093750; rs3093761; rs3093757; rs1151403; rs1151402; rs3093773; rs3093774; rs3093775; rs9587529; rs1151404; rs2776776; rs2232640; rs3093763; rs3093765; rs35469724; rs3742212; rs35874133; rs3093766; rs2232637; rs3093754; rs3093752; rs34383855; rs9706945; rs12875874; rs3093749; rs35399798; rs3093760; rs3093771; rs12875994; rs41308566; rs41315050; rs35417825; rs9520822; rs12016880; rs36219967; rs34562001; rs12866542; rs36219968; rs12866214; rs35961345; rs36219969; rs1105451; rs1151400; rs1151401; rs1151405; rs11620361; rs11841388; rs12428162; rs12428765; rs12429577; rs12429583; rs12430753; rs12874628; rs1473792; rs1555902; rs17497319; rs1853976; rs34214453; rs3809347; rs4772958; rs7322498; rs868284; rs915047; rs928550; rs9514825; rs9520820; rs9520823; rs9559281; rs9587525; rs9587526; rs9587527; rs9587528

# Metabolic_Enzyme_39_General_References:
7760816; 8798671; 9809069; 12547193; 10395545; 11349135; 11779494

# Metabolic_Enzyme_39_References:
Not Available

# Metabolic_Enzyme_40_ID:
5861

# Metabolic_Enzyme_40_Name:
Ubiquitin-conjugating enzyme E2 H

# Metabolic_Enzyme_40_Synonyms:
Ubiquitin-protein ligase H; Ubiquitin carrier protein H; UbcH2; E2-20K

# Metabolic_Enzyme_40_Gene_Name:
UBE2H

# Metabolic_Enzyme_40_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 
HMSSPSPGKRRMDTDVVKLIESKHEVTILGGLNEFVVKFYGPQGTPYEGGVWKVRVDLPD
KYPFKSPSIGFMNKIFHPNIDEASGTVCLDVINQTWTALYDLTNIFESFLPQLLAYPNPI
DPLNGDAAAMYLHRPEEYKQKIKEYIQKYATEEALKEQEEGTGDSSSESSMSDFSEDEAQ
DMEL

# Metabolic_Enzyme_40_Number_of_Residues:
183

# Metabolic_Enzyme_40_Molecular_Weight:
20655

# Metabolic_Enzyme_40_Theoretical_pI:
4.29

# Metabolic_Enzyme_40_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_40_General_Function:
Not Available

# Metabolic_Enzyme_40_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Capable, in vitro, to ubiquitinate histone H2A

# Metabolic_Enzyme_40_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_40_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_40_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_40_Signals:
None

# Metabolic_Enzyme_40_Transmembrane_Regions:
None

# Metabolic_Enzyme_40_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_40_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_40_GenBank_ID_Protein:
474827

# Metabolic_Enzyme_40_SwissProt_ID:
UBE2H_HUMAN (P62256)

# Metabolic_Enzyme_40_swissprot_Name:
Not Available

# Metabolic_Enzyme_40_Genecard_id:
UBE2H

# Metabolic_Enzyme_40_Geneatlas_id:
UBE2H

# Metabolic_Enzyme_40_hgnc_id:
HGNC:12484

# Metabolic_Enzyme_40_PDB_ID:
1YH6

# Metabolic_Enzyme_40_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_40_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_40_Subcellular_Location:
Not Available

# Metabolic_Enzyme_40_Gene_Sequence:
>552 bp
ATGTCATCTCCCAGTCCGGGCAAGAGGCGGATGGACACGGACGTGGTCAAGCTCATCGAG
AGTAAACATGAGGTTACGATCCTGGGAGGACTTAATGAATTTGTAGTGAAGTTTTATGGA
CCACAAGGAACACCATATGAAGGCGGAGTATGGAAAGTTAGAGTGGACCTACCTGATAAA
TACCCTTTCAAATCTCCATCTATAGGATTCATGAATAAAATTTTCCATCCCAACATTGAT
GAAGCGTCAGGAACTGTGTGTCTAGATGTAATTAATCAAACTTGGACAGCTCTCTATGAT
CTTACCAATATATTTGAGTCCTTCCTGCCTCAGTTATTGGCCTATCCTAACCCCATAGAT
CCTCTCAATGGTGACGCTGCAGCCATGTACCTCCACCGACCAGAAGAATACAAGCAGAAA
ATTAAAGAGTACATCCAGAAATACGCCACGGAGGAGGCGCTGAAAGAACAGGAAGAGGGT
ACCGGGGACAGCTCATCGGAGAGCTCTATGTCTGACTTTTCCGAAGATGAGGCCCAGGAT
ATGGAGTTGTAG

# Metabolic_Enzyme_40_GenBank_ID_Gene:
Z29328

# Metabolic_Enzyme_40_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_40_Locus:
7q32

# Metabolic_Enzyme_40_SNPs:
rs12539800; rs1046691; rs7639; rs1045897; rs2727500; rs1471876; rs2708637; rs1464973; rs1486831; rs2727487; rs12538787; rs2693741; rs7783328; rs718925; rs12537150; rs10215972; rs9656387; rs3807120; rs1471877; rs2727464; rs1725078; rs2727495; rs6467267; rs923231; rs3807121; rs12534043; rs12534061; rs12531936; rs2727476; rs6979056; rs12536424; rs2280680; rs2727499; rs12537660; rs3817530; rs3736214; rs3807118; rs12537576; rs12540517; rs17559596; rs2708653; rs17558874; rs10500121; rs12536978; rs2727480; rs12531622; rs2631601; rs12535347; rs2693747; rs2693722; rs10268712; rs7801603; rs12537782; rs2727507; rs12532959; rs10273782; rs2693721; rs11760945; rs2727492; rs12540541; rs1723728; rs1464972; rs12533528; rs12533033; rs7803795; rs1725077; rs2727482; rs2693740; rs2727479; rs10246707; rs1464971; rs12540479; rs12533290; rs17639187; rs6960765; rs7789191; rs12665878; rs17639487; rs2727461; rs2631603; rs10216153; rs2708649; rs10261367; rs16873739; rs2708651; rs2631602; rs11765073; rs17559441; rs10216157; rs17559301; rs7805042; rs7777157; rs7806091; rs2631606; rs2727490; rs9656386; rs7805384; rs2727494; rs2255639; rs7788714; rs10265243; rs1471874; rs10253233; rs7805717; rs3807119; rs6962745; rs1725079; rs7809265; rs2466981; rs17162295; rs11978225; rs2727497; rs10227968; rs2727506; rs13242512; rs1471875; rs7805045; rs2727458; rs12533464; rs7808987; rs1405239; rs12539145; rs7805736; rs2727477; rs2727460; rs12532612; rs17162123; rs2727466; rs2402980; rs2727488; rs12537336; rs12537604; rs17162050; rs7783474; rs2693724; rs7805552; rs6959075; rs3800561; rs12530557; rs2708641; rs7788461; rs718926; rs10249037; rs2631604; rs3807122; rs17162136; rs10240142; rs4731636; rs12534320; rs2727467; rs12535722; rs12535728; rs6963861; rs6964187; rs2727501; rs8485; rs1045896; rs1062977; rs11548945; rs11548944; rs34456570; rs17162882; rs8673; rs10486; rs1045894; rs34965300; rs1965568; rs34568839; rs7808364; rs35898647; rs35356388; rs2727489; rs11356893; rs34859314; rs34926272; rs11760768; rs35884790; rs5887456; rs36003769; rs35482241; rs11299056; rs17559568; rs34648726; rs34034618; rs28473687; rs11765213; rs11773785; rs2727485; rs35586367; rs4728180; rs10271802; rs2727475; rs1464970; rs6970225; rs35239982; rs2727462; rs11422674; rs11421202; rs5887452; rs34547874; rs6952373; rs34057112; rs2727481; rs34362444; rs7793305; rs35048152; rs28539366; rs3043708; rs2631607; rs34594241; rs1965567; rs34695655; rs7782413; rs13241892; rs35945331; rs2708648; rs2693725; rs13238461; rs3807115; rs1526323; rs35463166; rs2727478; rs34198937; rs2727484; rs10642301; rs5887455; rs2727498; rs10677960; rs11438278; rs35429139; rs11297139; rs35140578; rs11430559; rs35596978; rs13241340; rs34089543; rs13221952; rs4731638; rs35996659; rs2693742; rs11297393; rs36093184; rs34279042; rs34199011; rs7804954; rs34673682; rs2727463; rs7790079; rs1486830; rs1132932; rs35447763; rs13240058; rs35723763; rs3839653; rs12665979; rs4256541; rs34001143; rs10525494; rs34482065; rs34072997; rs34488741; rs2037720; rs34582657; rs5887451; rs35577888; rs5887454; rs34087329; rs34093190; rs1057928; rs2631605; rs11347186; rs13234123; rs35265871; rs2708642; rs35074582; rs34403102; rs7778053; rs11308308; rs28510253; rs3891318; rs28604351; rs11430560; rs10275798; rs2693743; rs2708650; rs3891319; rs35963787; rs11448310; rs2692443; rs34490269; rs3840552; rs3832461; rs12533468; rs35964242; rs2727496; rs34297290; rs35207398; rs34930431; rs35916150; rs13228286; rs6962972; rs3807116; rs2693746; rs35189138; rs34941204; rs2727483; rs35167740; rs34227624; rs34182980; rs2727491; rs2727486; rs5028472; rs12535857; rs13238782; rs11405982; rs34262631; rs35326390; rs2464894; rs28444603; rs34571747; rs5887453; rs2727459; rs34701981; rs34412294; rs1723727; rs35043856; rs34258788; rs2693744; rs10239779; rs3886312; rs10243840; rs35268874; rs6957308; rs10261345; rs34767129; rs12539653; rs3043701; rs11766498; rs2466987; rs35874993; rs10637757; rs34045760; rs11291694; rs7789336; rs2727493; rs34675108; rs13241012; rs35808448; rs34454670; rs11347187; rs35593803; rs4612285; rs10545721; rs10242002; rs35021353; rs34924795; rs11269421; rs6964169; rs2693723; rs3840551; rs35710137; rs11334941; rs35716732; rs34730487; rs35097197; rs11401650; rs2692442; rs1063296; rs34351192; rs35008319; rs3734927; rs13312322; rs34782630; rs3832460; rs10678531; rs34198617; rs12533953; rs12690; rs13238927; rs2631608; rs2693748; rs2727456; rs2727465; rs34629832; rs3734926; rs4728179; rs6980213; rs873664

# Metabolic_Enzyme_40_General_References:
8132613

# Metabolic_Enzyme_40_References:
Not Available

# Metabolic_Enzyme_41_ID:
5862

# Metabolic_Enzyme_41_Name:
High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A

# Metabolic_Enzyme_41_Synonyms:
HCP1; TM22

# Metabolic_Enzyme_41_Gene_Name:
PDE7A

# Metabolic_Enzyme_41_Protein_Sequence:
>Highaffinity cAMPspecific 3',5'cyclic phosphodiesterase 7
AMEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQT
ALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLR
SSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFS
LHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTP
WDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLF
SHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALK
CADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTY
LVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQEN
RLS

# Metabolic_Enzyme_41_Number_of_Residues:
482

# Metabolic_Enzyme_41_Molecular_Weight:
55506

# Metabolic_Enzyme_41_Theoretical_pI:
7.53

# Metabolic_Enzyme_41_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_41_General_Function:
Not Available

# Metabolic_Enzyme_41_Specific_Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase is highly specific for cAMP and may have a role in muscle signal transduction

# Metabolic_Enzyme_41_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_41_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_41_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_41_Signals:
None

# Metabolic_Enzyme_41_Transmembrane_Regions:
None

# Metabolic_Enzyme_41_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_41_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_41_GenBank_ID_Protein:
5566609

# Metabolic_Enzyme_41_SwissProt_ID:
PDE7A_HUMAN (Q13946)

# Metabolic_Enzyme_41_swissprot_Name:
Not Available

# Metabolic_Enzyme_41_Genecard_id:
PDE7A

# Metabolic_Enzyme_41_Geneatlas_id:
PDE7A

# Metabolic_Enzyme_41_hgnc_id:
HGNC:8791

# Metabolic_Enzyme_41_PDB_ID:
Not Available

# Metabolic_Enzyme_41_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_41_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_41_Subcellular_Location:
Note=PDE7A1 (57 kDa) is located mostly to soluble cellular fractions. PDE7A2 (50 kDa) is located to particulate cellular fractions

# Metabolic_Enzyme_41_Gene_Sequence:
>1449 bp
ATGGAAGTGTGTTACCAGCTGCCGGTACTGCCCCTGGACAGGCCGGTCCCCCAGCACGTC
CTCAGCCGCCGAGGAGCCATCAGCTTCAGCTCCAGCTCCGCTCTCTTCGGCTGCCCCAAT
CCCCGGCAGCTCTCTCAGAGGCGTGGAGCTATTTCCTATGACAGTTCTGATCAGACTGCA
TTATACATTCGTATGCTAGGAGATGTACGTGTAAGGAGCCGAGCAGGATTTGAATCAGAA
AGAAGAGGTTCTCACCCATATATTGATTTTCGTATTTTCCACTCTCAATCTGAAATTGAA
GTGTCTGTCTCTGCAAGGAATATCAGAAGGCTACTAAGTTTCCAGCGATATCTTAGATCT
TCACGCTTTTTTCGTGGTACTGCGGTTTCAAATTCCCTAAACATTTTAGATGATGATTAT
AATGGACAAGCCAAGTGTATGCTGGAAAAAGTTGGAAATTGGAATTTTGATATCTTTCTA
TTTGATAGACTAACAAATGGAAATAGTCTAGTAAGCTTAACCTTTCATTTATTTAGTCTT
CATGGATTAATTGAGTACTTCCATTTAGATATGATGAAACTTCGTAGATTTTTAGTTATG
ATTCAAGAAGATTACCACAGTCAAAATCCTTACCATAACGCAGTCCACGCTGCGGATGTT
ACTCAGGCCATGCACTGTTACTTAAAGGAACCTAAGCTTGCCAATTCTGTAACTCCTTGG
GATATCTTGCTGAGCTTAATTGCAGCTGCCACTCATGATCTGGATCATCCAGGTGTTAAT
CAACCTTTCCTTATTAAAACTAACCATTACTTGGCAACTTTATACAAGAATACCTCAGTA
CTGGAAAATCACCACTGGAGATCTGCAGTGGGCTTATTGAGAGAATCAGGCTTATTCTCA
CATCTGCCATTAGAAAGCAGGCAACAAATGGAGACACAGATAGGTGCTCTGATACTAGCC
ACAGACATCAGTCGCCAGAATGAGTATCTGTCTTTGTTTAGGTCCCATTTGGATAGAGGT
GATTTATGCCTAGAAGACACCAGACACAGACATTTGGTTTTACAGATGGCTTTGAAATGT
GCTGATATTTGTAACCCATGTCGGACGTGGGAATTAAGCAAGCAGTGGAGTGAAAAAGTA
ACGGAGGAATTCTTCCATCAAGGAGATATAGAAAAAAAATATCATTTGGGTGTGAGTCCA
CTTTGCGATCGTCACACTGAATCTATTGCCAACATCCAGATTGGTTTTATGACTTACCTA
GTGGAGCCTTTATTTACAGAATGGGCCAGGTTTTCCAATACAAGGCTATCCCAGACAATG
CTTGGACACGTGGGGCTGAATAAAGCCAGCTGGAAGGGACTGCAGAGAGAACAGTCGAGC
AGTGAGGACACTGATGCTGCATTTGAGTTGAACTCACAGTTATTACCTCAGGAAAATCGG
TTATCATAA

# Metabolic_Enzyme_41_GenBank_ID_Gene:
L12052

# Metabolic_Enzyme_41_Chromosome_Location:
Not Available

# Metabolic_Enzyme_41_Locus:
Not Available

# Metabolic_Enzyme_41_SNPs:
Not Available

# Metabolic_Enzyme_41_General_References:
8389765; 9195912

# Metabolic_Enzyme_41_References:
Not Available

# Metabolic_Enzyme_42_ID:
5756

# Metabolic_Enzyme_42_Name:
Biotin--protein ligase

# Metabolic_Enzyme_42_Synonyms:
Biotin apo-protein ligase[Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase; Holocarboxylase synthetase; HCS; Biotin-- [methylcrotonoyl-CoA-carboxylase] ligase

# Metabolic_Enzyme_42_Gene_Name:
HLCS

# Metabolic_Enzyme_42_Protein_Sequence:
>Biotinprotein ligase
MEDRLHMDNGLVPQKIVSVHLQDSTLKEVKDQVSNKQAQILEPKPEPSLEIKPEQDGMEH
VGRDDPKALGEEPKQRRGSASGSEPAGDSDRGGGPVEHYHLHLSSCHECLELENSTIESV
KFASAENIPDLPYDYSSSLESVADETSPEREGRRVNLTGKAPNILLYVGSDSQEALGRFH
EVRSVLADCVDIDSYILYHLLEDSALRDPWTDNCLLLVIATRESIPEDLYQKFMAYLSQG
GKVLGLSSSFTFGGFQVTSKGALHKTVQNLVFSKADQSEVKLSVLSSGCRYQEGPVRLSP
GRLQGHLENEDKDRMIVHVPFGTRGGEAVLCQVHLELPPSSNIVQTPEDFNLLKSSNFRR
YEVLREILTTLGLSCDMKQVPALTPLYLLSAAEEIRDPLMQWLGKHVDSEGEIKSGQLSL
RFVSSYVSEVEITPSCIPVVTNMEAFSSEHFNLEIYRQNLQTKQLGKVILFAEVTPTTMR
LLDGLMFQTPQEMGLIVIAARQTEGKGRGGNVWLSPVGCALSTLLISIPLRSQLGQRIPF
VQHLMSVAVVEAVRSIPEYQDINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYILIGC
GFNVTNSNPTICINDLITEYNKQHKAELKPLRADYLIARVVTVLEKLIKEFQDKGPNSVL
PLYYRYWVHSGQQVHLGSAEGPKVSIVGLDDSGFLQVHQEGGEVVTVHPDGNSFDMLRNL
ILPKRR

# Metabolic_Enzyme_42_Number_of_Residues:
726

# Metabolic_Enzyme_42_Molecular_Weight:
80761

# Metabolic_Enzyme_42_Theoretical_pI:
5.34

# Metabolic_Enzyme_42_GO_Classification:
>>>
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  biotin-protein ligase activity
Function:  biotin-[acetyl-CoA-carboxylase] ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_42_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_42_Specific_Function:
Posttranslational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase

# Metabolic_Enzyme_42_Pathway:
map00780  Biotin metabolism

# Metabolic_Enzyme_42_Reaction:
ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

# Metabolic_Enzyme_42_Pfam_Domain_Function:
PF02237:BPL_C;
PF03099:BPL_LipA_LipB

# Metabolic_Enzyme_42_Signals:
None

# Metabolic_Enzyme_42_Transmembrane_Regions:
None

# Metabolic_Enzyme_42_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_42_EC_Link:
EC 6.3.4.9;EC 6.3.4.10;EC

# Metabolic_Enzyme_42_GenBank_ID_Protein:
577625

# Metabolic_Enzyme_42_SwissProt_ID:
BPL1_HUMAN (P50747)

# Metabolic_Enzyme_42_swissprot_Name:
Not Available

# Metabolic_Enzyme_42_Genecard_id:
HLCS

# Metabolic_Enzyme_42_Geneatlas_id:
HLCS

# Metabolic_Enzyme_42_hgnc_id:
HGNC:4976

# Metabolic_Enzyme_42_PDB_ID:
Not Available

# Metabolic_Enzyme_42_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_42_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_42_Subcellular_Location:
Cytoplasm. Mitochondrion

# Metabolic_Enzyme_42_Gene_Sequence:
>2181 bp
ATGGAAGATAGACTCCACATGGATAATGGACTGGTACCCCAAAAGATTGTGTCGGTGCAC
TTGCAGGACTCCACTCTGAAGGAAGTTAAGGATCAGGTCTCAAACAAGCAAGCCCAGATC
CTAGAGCCGAAGCCTGAACCTTCTCTTGAGATTAAGCCTGAGCAGGACGGTATGGAGCAT
GTTGGCAGAGATGACCCAAAGGCTCTTGGTGAAGAACCCAAACAAAGGAGAGGCAGTGCC
TCTGGGAGTGAGCCTGCTGGGGACAGTGACAGGGGAGGGGGCCCCGTTGAGCATTATCAC
CTCCATCTGTCTAGTTGCCACGAGTGTCTGGAACTTGAGAACAGCACCATTGAGTCAGTC
AAGTTTGCGTCTGCCGAGAACATTCCAGACCTTCCCTACGATTATAGCAGCAGTTTGGAG
AGTGTTGCTGATGAGACCTCCCCCGAAAGAGAAGGGAGGAGAGTCAACCTCACGGGAAAG
GCACCCAACATCCTCCTCTATGTGGGCTCCGACTCCCAGGAAGCCCTCGGCCGGTTCCAC
GAGGTCCGGTCTGTGCTGGCCGACTGTGTGGACATTGACAGTTATATTCTCTACCACCTG
CTGGAGGACAGTGCTCTCAGAGACCCGTGGACGGACAACTGTCTGCTGTTGGTCATTGCT
ACCAGGGAGTCCATTCCCGAAGACCTGTACCAGAAGTTCATGGCCTATCTTTCTCAGGGA
GGGAAGGTGTTGGGCCTGTCTTCATCCTTCACCTTTGGTGGCTTTCAGGTGACAAGCAAG
GGTGCACTGCACAAGACAGTCCAGAACTTGGTTTTCTCCAAGGCTGACCAGAGCGAGGTG
AAGCTCAGCGTCTTGAGCAGTGGCTGCAGGTACCAGGAAGGCCCCGTCCGGCTCAGCCCC
GGCAGGCTCCAGGGCCACCTGGAGAATGAGGACAAGGACAGGATGATTGTGCATGTGCCT
TTTGGAACTCGCGGGGGAGAAGCTGTTCTTTGCCAGGTGCACTTAGAACTACCTCCCAGC
TCCAACATAGTGCAAACTCCAGAAGATTTTAACTTGCTCAAGTCAAGCAATTTTAGAAGA
TACGAAGTCCTTAGAGAGATTCTGACAACCCTTGGCCTCAGCTGTGACATGAAACAAGTT
CCTGCCTTAACTCCTCTTTACTTGCTGTCAGCTGCGGAGGAAATCAGGGATCCTCTTATG
CAGTGGCTTGGGAAACATGTGGACTCCGAGGGAGAAATAAAATCCGGCCAGCTCTCTCTT
AGATTTGTTTCATCCTACGTGTCTGAAGTAGAAATAACCCCATCTTGTATACCTGTGGTG
ACCAACATGGAGGCCTTCTCATCAGAACATTTCAACTTAGAGATCTATCGCCAAAATCTG
CAGACCAAGCAGTTGGGGAAAGTAATTTTGTTTGCCGAAGTGACCCCCACAACGATGCGT
CTCCTGGATGGGCTGATGTTTCAGACACCGCAGGAAATGGGCTTAATAGTGATCGCGGCC
CGGCAGACCGAGGGCAAAGGACGGGGAGGGAATGTGTGGCTGAGCCCTGTGGGATGTGCT
CTTTCTACTCTGCTCATCTCCATTCCACTGAGATCCCAGCTGGGACAGAGGATCCCGTTT
GTCCAGCATCTGATGTCCGTGGCTGTCGTGGAAGCAGTGAGGTCCATTCCCGAGTATCAG
GATATCAACTTACGAGTGAAGTGGCCCAACGATATTTATTACAGTGACCTCATGAAGATC
GGCGGAGTTCTGGTTAACTCAACACTCATGGGAGAAACATTTTATATACTTATTGGCTGT
GGATTTAATGTGACTAACAGTAACCCTACCATCTGCATCAACGACCTCATCACAGAATAC
AATAAACAACACAAGGCAGAACTGAAGCCCTTAAGAGCCGATTATCTCATCGCCAGAGTC
GTGACTGTGCTGGAGAAACTGATCAAAGAGTTTCAGGACAAAGGGCCCAACAGCGTCCTT
CCCCTTTATTACCGATACTGGGTCCACAGTGGTCAGCAAGTCCATCTGGGCAGCGCAGAG
GGACCAAAGGTGTCCATCGTTGGCCTGGACGATTCTGGCTTCCTCCAGGTTCACCAGGAG
GGCGGCGAGGTTGTGACTGTGCACCCGGACGGCAACTCCTTCGACATGCTGAGAAACCTC
ATCCTCCCCAAACGGCGGTAA

# Metabolic_Enzyme_42_GenBank_ID_Gene:
D23672

# Metabolic_Enzyme_42_Chromosome_Location:
Not Available

# Metabolic_Enzyme_42_Locus:
Not Available

# Metabolic_Enzyme_42_SNPs:
rs1065759; rs1065758; rs2230182; rs2835547; rs2835543; rs2835554; rs2835544; rs1892916; rs2835553; rs2835545; rs2016215; rs2835557; rs2835546; rs2835552; rs9636908; rs2835548; rs2835555; rs1893653; rs2835550; rs2843637; rs3827189; rs2835549; rs2835541; rs4817839; rs12626528; rs8126588; rs8127595; rs2835551; rs11910240; rs12627541; rs6517397; rs369888; rs2835556; rs10084553; rs2845814; rs4816551; rs2409871; rs12483284; rs1571702; rs4817840; rs762373; rs445437; rs997627; rs2032087; rs12483456; rs762376; rs1893654; rs7277523; rs1893655; rs1571700; rs9978381; rs727961; rs6517396; rs3827190; rs3179477; rs6517395; rs4816557; rs7281321; rs14407; rs7276605; rs7283846; rs2409870; rs7277447; rs3819154; rs7282108; rs7280331; rs13052315; rs8127236; rs2835542; rs762374; rs12626531; rs1050706; rs7281251; rs2154530; rs13048613; rs13049125; rs11700650; rs9636909; rs8129634; rs11909178; rs11702480; rs9981774; rs9983516; rs1007423; rs11701986; rs8131277; rs7509886; rs7276406; rs4817832; rs2154533; rs762375; rs12482985; rs4817835; rs11909152; rs2154532; rs8126740; rs4816553; rs2843627; rs7276518; rs1012962; rs7280892; rs1986063; rs9981407; rs16997934; rs7509870; rs1055700; rs2016219; rs8130063; rs3191054; rs7276371; rs9967991; rs412162; rs2154529; rs7282422; rs1050707; rs4817838; rs12626619; rs1055699; rs2032086; rs1007421; rs10084551; rs4817834; rs12626945; rs2843633; rs9974970; rs9976131; rs2835520; rs2835489; rs2835535; rs2835505; rs2835472; rs2835531; rs2835463; rs2073425; rs2835516; rs765321; rs1984020; rs2835537; rs2835511; rs2835506; rs745147; rs2835532; rs2835480; rs2256034; rs2245447; rs2835515; rs2835483; rs2835455; rs2835454; rs2245524; rs2835474; rs2835510; rs2835487; rs1041437; rs2835538; rs2000550; rs2835539; rs2835534; rs2835486; rs2835465; rs2835485; rs2835519; rs2835513; rs2245349; rs2835525; rs2073424; rs3827185; rs3787749; rs2835508; rs2835467; rs7280984; rs2835491; rs2073420; rs2236435; rs2835499; rs762369; rs1892913; rs2156419; rs8134067; rs999373; rs1010385; rs3787755; rs2835500; rs2835458; rs8129544; rs3787759; rs7280602; rs2835527; rs6517385; rs2000549; rs2835484; rs2835471; rs8127309; rs999372; rs2835461; rs6517394; rs3787741; rs2835478; rs2835488; rs2835498; rs6517390; rs2835468; rs8130819; rs2835481; rs2835495; rs2835477; rs2245353; rs3787756; rs8134742; rs11088366; rs12627703; rs2835497; rs2835482; rs2835517; rs2835529; rs2835493; rs2835533; rs2835464; rs1015017; rs9978519; rs743429; rs2835503; rs2835509; rs8134293; rs2835514; rs2835473; rs8133376; rs8129637; rs762370; rs2835502; rs3787771; rs1467857; rs2835476; rs9981318; rs2835466; rs3787751; rs2835526; rs3787764; rs6517386; rs2835528; rs766212; rs928845; rs2835504; rs8131323; rs8133029; rs9977855; rs2835459; rs2187305; rs2835479; rs2156420; rs7282868; rs2835530; rs12627271; rs2835501; rs6517384; rs11702761; rs1009778; rs2845810; rs3787739; rs2845805; rs8131621; rs3787752; rs9941899; rs7278038; rs9981513; rs4402840; rs2835524; rs2845811; rs1023409; rs12627285; rs11910692; rs8134448; rs2850120; rs2835507; rs2835496; rs6517392; rs8130179; rs2073421; rs6517389; rs11701858; rs3787748; rs11088368; rs16994604; rs12627666; rs9981651; rs2835475; rs2073419; rs2835494; rs2016223; rs12151959; rs2845804; rs2835518; rs2845812; rs6517391; rs9977488; rs7279278; rs2835470; rs8132538; rs7275269; rs2276230; rs9680246; rs10483036; rs2835523; rs2835490; rs10154119; rs6517388; rs13047304; rs1029248; rs8131480; rs11088367; rs7276758; rs2070523; rs3827187; rs8134687; rs12481910; rs2835453; rs743430; rs2409842; rs2073422; rs16994521; rs7276082; rs2835457; rs7276265; rs12627662; rs762367; rs9977769; rs3787757; rs2835536; rs13050480; rs2835469; rs2409865; rs2850104; rs2850106; rs11910768; rs7275322; rs725719; rs2105752; rs11702134; rs2236434; rs8134083; rs2845817; rs1029247; rs2835492; rs2835521; rs13052249; rs6517387; rs2073423; rs4817822; rs9636905; rs9647169; rs8127553; rs13047322; rs3787754; rs732252; rs1041832; rs8130235; rs8132874; rs16994508; rs3827188; rs2835462; rs7276185; rs2898312; rs7278981; rs8133818; rs999374; rs11911767; rs16994519; rs11701035; rs3787750; rs2073418; rs2850118; rs3787765; rs7277563; rs2835460; rs17228878; rs11701632; rs13050751; rs8131510; rs8129230; rs8132327; rs7278075; rs6517381; rs2245325; rs3842450; rs4817828; rs7283004; rs16997932; rs12627476; rs7281419; rs16994573; rs11700783; rs2065303; rs17192962; rs11700880; rs8129291; rs8131843; rs11088365; rs4501027; rs8132225; rs3838087; rs7278053; rs12627335; rs933159; rs762368; rs3787767; rs7280590; rs12481800; rs8130004; rs3787753; rs12483475; rs17814272; rs10451759; rs8129887; rs2282501; rs9647072; rs7510213; rs8132547; rs12482724; rs3787768; rs4817823; rs1968034; rs16994591; rs12626955; rs9977713; rs8126803; rs7279810; rs12626368; rs16994424; rs2845819; rs11702434; rs8129140; rs8132325; rs960498; rs11702727; rs8130658; rs1968035; rs12627519; rs3787740; rs17814278; rs13052574; rs9978312; rs4817821; rs8134086; rs11909707; rs8131697; rs16994586; rs4146071; rs3787760; rs7509790; rs7280746; rs11909766; rs2835522; rs2850119; rs2845813; rs7279818; rs16994438; rs2409867; rs11911648; rs7283401; rs17228899; rs1892912; rs17284196; rs16994530; rs2835456; rs9305605; rs11701958; rs11910919; rs7283417; rs16994503; rs2835512; rs7283871; rs16994435; rs8130485; rs8130689; rs9985116; rs10154239; rs7280597; rs2850105; rs16994594; rs2850103; rs7280357; rs7283538; rs13045992; rs11088364; rs2898305; rs2032320; rs2096494; rs28934602; rs10586592; rs7280923; rs11393391; rs4817837; rs3035109; rs10555694; rs6147500; rs28593435; rs2010867; rs13050516; rs4816555; rs35275580; rs11911628; rs3035147; rs13047776; rs10439668; rs2250250; rs9976746; rs35410170; rs34322027; rs11088370; rs9978378; rs34080483; rs4817833; rs5843777; rs34917953; rs12481939; rs35414914; rs7283304; rs8130102; rs35626237; rs4817836; rs34507014; rs3035114; rs11911653; rs35627163; rs35955622; rs35662085; rs35497414; rs2154531; rs12627081; rs9975027; rs13046475; rs9980304; rs7281145; rs10714466; rs35614243; rs9979522; rs11327894; rs35458660; rs34562090; rs28690635; rs33973072; rs28429232; rs34401947; rs11446217; rs11386640; rs8131045; rs35291269; rs28650072; rs1571701; rs4816552; rs34710014; rs12627106; rs2848944; rs28694191; rs28530; rs11326506; rs3031056; rs34107101; rs10572120; rs35365431; rs10658878; rs28873986; rs35392286; rs35583976; rs2845823; rs35174119; rs34036236; rs35269254; rs11345329; rs7276359; rs7280124; rs2848945; rs7276076; rs13050356; rs5843783; rs13049535; rs35601107; rs34807872; rs2845822; rs1540010; rs2843959; rs34377311; rs12626655; rs35868871; rs35980239; rs35710980; rs4816554; rs35634082; rs13049080; rs34220466; rs35662012; rs35520036; rs34080155; rs13046468; rs13050438; rs3035105; rs7280358; rs13050355; rs35779811; rs36112603; rs28610288; rs13050617; rs8128381; rs12481773; rs3787776; rs35700333; rs3035112; rs33951816; rs13051338; rs9984942; rs13052725; rs34357006; rs8133111; rs36042341; rs9983255; rs35509622; rs2850116; rs35869521; rs11294369; rs35182597; rs4437044; rs11297044; rs12483583; rs9305606; rs9680205; rs35822038; rs5843781; rs11702621; rs13053024; rs35796252; rs35095559; rs34254252; rs2845809; rs34407031; rs34091454; rs12152092; rs11701245; rs34788426; rs11390960; rs1892914; rs2409866; rs10533053; rs13050215; rs34132309; rs1080320; rs11367391; rs34296856; rs4817819; rs34750859; rs7510407; rs10222039; rs10222041; rs34494258; rs36115487; rs10527838; rs7281668; rs10675191; rs12482385; rs36094571; rs34518438; rs11700970; rs7280703; rs35996984; rs34580139; rs11701954; rs4816549; rs36030626; rs35066001; rs7278768; rs35736294; rs28433522; rs34042688; rs10667373; rs34834985; rs35033735; rs28420273; rs34614171; rs4817826; rs13048483; rs10578979; rs34474993; rs9978513; rs35086153; rs7281557; rs35055957; rs28717023; rs34606135; rs34108918; rs34352427; rs9305607; rs4817820; rs10673271; rs34525201; rs11464249; rs10671954; rs34011883; rs34569598; rs13048364; rs35780817; rs3787762; rs1807005; rs7277291; rs35188541; rs2850117; rs35393537; rs34364909; rs11297456; rs34450454; rs6517380; rs34753772; rs2845818; rs34057978; rs8128030; rs34115036; rs7276860; rs35778622; rs2845808; rs11384058; rs12626778; rs10701851; rs35753864; rs13049458; rs9980828; rs8127419; rs35751606; rs11909879; rs11297170; rs35402890; rs34791770; rs35945376; rs34814328; rs28478303; rs2850107; rs34260234; rs10660857; rs12482621; rs34247489; rs34777766; rs11306825; rs36038593; rs34292112; rs34938617; rs11418922; rs34340177; rs8133296; rs11317768; rs7278191; rs2898307; rs9975316; rs11701120; rs34199456; rs36086662; rs11291576; rs35352430; rs35493457; rs8130859; rs34541224; rs2845815; rs9979967; rs35818278; rs8134476; rs35808041; rs33933191; rs34276663; rs17461392; rs13047682; rs7283722; rs28837399; rs2845807; rs2845816; rs13047748; rs12627632; rs34836716; rs7281692; rs34141324; rs8134223; rs35389223; rs8127533; rs35468614; rs8128099; rs35329905; rs11908840; rs12627303; rs10460714; rs7278010; rs34602439; rs34203769; rs2409864; rs1023151; rs28393024; rs34954888; rs34016490; rs35012674; rs8134332; rs35663376; rs35419478; rs13047923; rs35436718; rs4146072; rs34087473; rs36053269; rs34963503; rs9305608; rs9636906; rs34820991; rs35737292; rs35524379; rs7277631; rs3787747; rs34722227; rs11464248; rs34473124; rs34498809; rs5843779; rs4817824; rs11344082; rs10683958; rs766213; rs36004832; rs35877361; rs36071670; rs10601692; rs8127710; rs35854823; rs34695780; rs2898306; rs34861975; rs11445706; rs3787763; rs35372493; rs35181716; rs4817829; rs35148498; rs13052306; rs34623773; rs9982979; rs34491680; rs8128357; rs765322; rs12627215; rs35114323; rs34254349; rs7279029; rs5843780; rs4817825; rs6517382; rs8134282; rs3838088; rs35086549; rs35178355; rs36094620; rs2845806; rs34601566; rs16994535; rs34372660; rs2409841; rs7276595; rs34045793; rs35693831; rs9636907; rs33997626; rs35529573; rs13049750; rs9631176; rs35395049; rs35754533; rs34877069; rs35184977; rs28625302; rs11701876; rs34016299; rs3840081; rs2409868; rs11287408; rs35744528; rs11908847; rs35420087; rs11290275; rs11323079; rs35056286; rs10699749; rs35246209; rs11464250; rs7280002; rs5843778; rs35247519; rs11353178; rs36000333; rs11088363; rs34153712; rs34389255; rs16994517; rs35042573; rs36027016; rs35323345; rs11701088; rs11464247; rs34592171; rs35050680; rs34390839; rs10696901; rs8127560; rs34392668; rs9680178; rs34427088; rs9984754; rs36040380; rs34908465; rs7282396; rs34792541; rs3132398; rs2843630; rs3094305; rs2843629; rs35788112; rs1005404; rs12627480; rs13050453; rs13052602; rs16994660; rs1892915; rs1893656; rs1970053; rs2002799; rs2051397; rs2070519; rs2070520; rs2073416; rs2073417; rs2073601; rs2073602; rs2073603; rs2186335; rs2187102; rs2409872; rs2835451; rs2835540; rs2843961; rs7281817; rs8131293; rs8132470; rs877686; rs9982519

# Metabolic_Enzyme_42_General_References:
7842009; 11735028; 10830953; 9503011; 8541348; 8817339; 9396568; 10190325

# Metabolic_Enzyme_42_References:
Not Available

# Metabolic_Enzyme_43_ID:
5863

# Metabolic_Enzyme_43_Name:
Arginyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_43_Synonyms:
Arginine--tRNA ligase; ArgRS

# Metabolic_Enzyme_43_Gene_Name:
RARS

# Metabolic_Enzyme_43_Protein_Sequence:
>ArginyltRNA synthetase, cytoplasmic
MDVLVSECSARLLQQEEEIKSLTAEIDRLKNCGCLGASPNLEQLQEENLKLKYRLNILRK
SLQAERNKPTKNMINIISRLQEVFGHAIKAAYPDLENPPLLVTPSQQAKFGDYQCNSAMG
ISQMLKTKEQKVNPREIAENITKHLPDNECIEKVEIAGPGFINVHLRKDFVSEQLTSLLV
NGVQLPALGENKKVIVDFSSPNIAKEMHVGHLRSTIIGESISRLFEFAGYDVLRLNHVGD
WGTQFGMLIAHLQDKFPDYLTVSPPIGDLQVFYKESKKRFDTEEEFKKRAYQCVVLLQGK
NPDITKAWKLICDVSRQELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRGFVQVDDG
RKIVFVPGCSIPLTIVKSDGGYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQSVHFQTIF
AAAQMIGWYDPKVTRVFHAGFGVVLGEDKKKFKTRSGETVRLMDLLGEGLKRSMDKLKEK
ERDKVLTAEELNAAQTSVAYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTR
IRSIARLANIDEEMLQKAARETKILLDHEKEWKLGRCILRFPEILQKILDDLFLHTLCDY
IYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM


# Metabolic_Enzyme_43_Number_of_Residues:
660

# Metabolic_Enzyme_43_Molecular_Weight:
75380

# Metabolic_Enzyme_43_Theoretical_pI:
6.65

# Metabolic_Enzyme_43_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  arginine-tRNA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  arginyl-tRNA aminoacylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_43_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_43_Specific_Function:
ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)

# Metabolic_Enzyme_43_Pathway:
map00330  Arginine and proline metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_43_Reaction:
ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)

# Metabolic_Enzyme_43_Pfam_Domain_Function:
PF03485:Arg_tRNA_synt_N;
PF05746:DALR_1;
PF00750:tRNA-synt_1d

# Metabolic_Enzyme_43_Signals:
None

# Metabolic_Enzyme_43_Transmembrane_Regions:
None

# Metabolic_Enzyme_43_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_43_EC_Link:
EC 6.1.1.19

# Metabolic_Enzyme_43_GenBank_ID_Protein:
1217668

# Metabolic_Enzyme_43_SwissProt_ID:
SYRC_HUMAN (P54136)

# Metabolic_Enzyme_43_swissprot_Name:
Not Available

# Metabolic_Enzyme_43_Genecard_id:
RARS

# Metabolic_Enzyme_43_Geneatlas_id:
RARS

# Metabolic_Enzyme_43_hgnc_id:
HGNC:9870

# Metabolic_Enzyme_43_PDB_ID:
Not Available

# Metabolic_Enzyme_43_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_43_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_43_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_43_Gene_Sequence:
>1980 bp
ATGGACGTACTGGTGTCTGAGTGCTCCGCGCGGCTGCTGCAGCAGGAAGAAGAGATTAAA
TCTCTGACTGCTGAAATTGACCGGTTGAAAAACTGTGGCTGTTTAGGAGCTTCTTCAAAT
TTGGAGCAGTTACAAGAAGAAAATTTAAAATTAAAGTATCGACTGAATATTCTTCGAAAG
AGTCTTCAGGCAGAAAGGAACAAACCAACTAAAAATATGATTAACATTATTAGCCGCCTA
CAAGAGGTCTTTGGTCATGCAATTAAGGCTGCATATCCAGATTTGGAAAATCCTCCTCTG
CTAGTGACACCAAGTCAGCAGGCCAAGTTTGGGGACTATCAGTGTAATAGTGCTATGGGT
ATTTCTCAGATGCTTAAAACCAAGGAACCGGAAGTTAATCCAGGGGAATTTGCTGAAAAC
ATTACCAAACACCTCCCGGCCATGGATGTTTTGAAAAGAGTTGAATTTGCTGGCCCTGGC
TTTATTAATGGCCACTTAAGAAAGGATTTTGTATCAGAACAATTGACCAGTCTTCTAGTG
AATGGAGTTCAACTACCTGCTCTGGGAGAGAATAAAAAGGTTATAGTTGACTTTTCCTCC
CCTAATATAGCTAAAGAGATGCATGTAGGCCACCTGAGGTCAACTATCATAGGAGAGAGT
ATAAGCCGCCTCTTTGAATTTGCAGGGTATGACGTGCTCAGGTTAAATCATGTAGGAGAC
TGGGGGACCCAGTTTGGCATGCTCATCGCTCACCTGCAAGACAAATTTCCAGATTATCTA
ACAGTTTCACCTCCTATTGGGGATCTTCAGGTCTTTTATAAGGAATCTAAGAAGAGGTTT
GATACTGAGGAGGAATTTAAGAAGCGAGCATATCAGTGTGTAGTTCTGCTCCAGGGTAAA
AACCCAGATATTACAAAAGCTTATCTGCTGATGTCTGATGTCTCCCGCCAAGAGTTAAAT
AAAATCTATGATGCATTGGACGTCTCTTTAATAGAGAGAGGGGAATCCTTCTATCAAGAT
AGGATGAATGATATTGTAAAGGAATTTGAAGATAGAGGATTTGTGCAGGTGGATGATGGC
AGAAAGATTGTATTTGTCCCAGGGTGTTCCATACCATTAACCATAGTAAAATCAGATGGA
GGTTATACCTATGATACATCTGACCTGGCTGCTATTAAACAAAGACTATTTGAGGAAAAA
GCAGATATGATTATCTATGTTGTGGACAATGGACAATCTGTGCACTTCCAGACAATATTT
GCTGCTGCTCAAATGATTGGTTGGTATGACCCTAAAGTAACTCGAGTCTTCCATGCTGGA
TTTGGTGTGGTGCTAGGGGAAGACAAGAAAAAGTTTAAAACACGTTCGGGTGAAACAGTG
CGCCTCATGGATCTTCTGGGAGAAGGACTAAAACGATCCATGGACAAGTTGAAGGAAAAA
GAAAGAGACAAGGTCTTAACTGCAGAGGAATTGAATGCTGCTCAGACATCCGTTGCATAT
GGCTGCATCAAATATGCTGACCTTTCCCATAACCGGTTGAATGACTACATCTTCTCCTTT
GACAAAATGCTAGATGACAGAGGAAATACAGCTGCTTACTTGTTGTATGCCTTCACTAGA
ATCAGGTCTATTGCACGTCTGGCCAATATTGATGAAGAAATGCTCCAAAAAGCTGCTCGA
GAAACCAAGATTCTTTTGGTTCATGAGAAGGAATGGAAACTAGGCCGGTGCATTTTACGG
TTCCCTGAGATTCTGCAAAAGATTTTAGATGACTTATTTCTCCACACTCTCTGTGATTAT
ATATATGAGCTGGCAACTGCTTTCACAGAGTTCTATGATAGCTGCTACTGTGTGGAGAAA
GATAGACAGACTGGGAAAATATTGAAGGTGAACATGTGGCGTATCTTGTGTGAAACAGTA
GCTGCTGTCATGGCCAAGGGGTTTGATACCCTGGGGATAAAACCTGGCCCAAGGGTGTAA


# Metabolic_Enzyme_43_GenBank_ID_Gene:
S80343

# Metabolic_Enzyme_43_Chromosome_Location:
Not Available

# Metabolic_Enzyme_43_Locus:
Not Available

# Metabolic_Enzyme_43_SNPs:
Not Available

# Metabolic_Enzyme_43_General_References:
7590355; 12665801

# Metabolic_Enzyme_43_References:
Not Available

# Metabolic_Enzyme_44_ID:
5864

# Metabolic_Enzyme_44_Name:
GMP synthase [glutamine-hydrolyzing]

# Metabolic_Enzyme_44_Synonyms:
Glutamine amidotransferase; GMP synthetase

# Metabolic_Enzyme_44_Gene_Name:
GMPS

# Metabolic_Enzyme_44_Protein_Sequence:
>GMP synthase glutaminehydrolyzing
MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETP
AFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHK
KSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANE
SKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVL
VLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAA
HSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPE
EVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVR
ILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPH
TLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDW
ESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILR
ESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVE
VVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE

# Metabolic_Enzyme_44_Number_of_Residues:
693

# Metabolic_Enzyme_44_Molecular_Weight:
76716

# Metabolic_Enzyme_44_Theoretical_pI:
6.86

# Metabolic_Enzyme_44_GO_Classification:
>>>
Function:  GMP synthase (glutamine-hydrolyzing) activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Function:  GMP synthase (glutamine-hydrolyzing) activity
Function:  molecular function unknown
Function:  catalytic activity
 ||
>>>
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
Process:  GMP biosynthesis
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_44_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_44_Specific_Function:
Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division

# Metabolic_Enzyme_44_Pathway:
map00230  Purine metabolism;
 map00251  Glutamate metabolism

# Metabolic_Enzyme_44_Reaction:
ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate

# Metabolic_Enzyme_44_Pfam_Domain_Function:
PF06508:ExsB;
PF00117:GATase;
PF00958:GMP_synt_C

# Metabolic_Enzyme_44_Signals:
None

# Metabolic_Enzyme_44_Transmembrane_Regions:
None

# Metabolic_Enzyme_44_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_44_EC_Link:
EC 6.3.5.2

# Metabolic_Enzyme_44_GenBank_ID_Protein:
595410

# Metabolic_Enzyme_44_SwissProt_ID:
GUAA_HUMAN (P49915)

# Metabolic_Enzyme_44_swissprot_Name:
Not Available

# Metabolic_Enzyme_44_Genecard_id:
GMPS

# Metabolic_Enzyme_44_Geneatlas_id:
GMPS

# Metabolic_Enzyme_44_hgnc_id:
HGNC:4378

# Metabolic_Enzyme_44_PDB_ID:
Not Available

# Metabolic_Enzyme_44_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_44_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_44_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_44_Gene_Sequence:
>2082 bp
ATGGCTCTGTGCAACGGAGACTCCAAGCTGGAGAATGCTGGAGGAGACCTTAAGGATGGC
CACCACCACTATGAAGGAGCTGTTGTCATTCTGGATGCTGGTGCTCAGTACGGGAAAGTC
ATAGACCGAAGAGTGAGGGAACTGTTCGTGCAGTCTGAAATTTTCCCCTTGGAAACACCA
GCATTTGCTATAAAGGAACAAGGATTCCGTGCTATTATCATCTCTGGAGGACCTAATTCT
GTGTATGCTGAAGATGCTCCCTGGTTTGATCCAGCAATATTCACTATTGGCAAGCCTGTT
CTTGGAATTTGCTATGGTATGCAGATGATGAATAAGGTATTTGGAGGTACTGTGCACAAA
AAAAGTGTCAGAGAAGATGGAGTTTTCAACATTAGTGTGGATAATACATGTTCATTATTC
AGGGGCCTTCAGAAGGAAGAAGTTGTTTTGCTTACACATGGAGATAGTGTAGACAAAGTA
GCTGATGGATTCAAGGTTGTGGCACGTTCTGGAAACATAGTAGCAGGCATAGCAAATGAA
TCTAAAAAGTTATATGGAGCACAGTTCCACCCTGAAGTTGGCCTTACAGAAAATGGAAAA
GTAATACTGAAGAATTTCCTTTATGATATAGCTGGATGCAGTGGAACCTTCACCGTGCAG
AACAGAGAACTTGAGTGTATTCGAGAGATCAAAGAGAGAGTAGGCACGTCAAAAGTTTTG
GTTTTACTCAGTGGTGGAGTAGACTCAACAGTTTGTACAGCTTTGCTAAATCGTGCTTTG
AACCAAGAACAAGTCATTGCTGTGCACATTGATAATGGCTTTATGAGAAAACGAGAAAGC
CAGTCTGTTGAAGAGGCCCTCAAAAAGCTTGGAATTCAGGTCAAAGTGATAAATGCTGCT
CATTCTTTCTACAATGGAACAACAACCCTACCAATATCAGATGAAGATAGAACCCCACGG
AAAAGAATTAGCAAAACGTTAAATATGACCACAAGTCCTGAAGAGAAAAGAAAAATCATT
GGGGATACTTTTGTTAAGATTGCCAATGAAGTAATTGGAGAAATGAACTTGAAACCAGAG
GAGGTTTTCCTTGCCCAAGGTACTTTACGGCCTGATCTAATTGAAAGTGCATCCCTTGTT
GCAAGTGGCAAAGCTGAACTCATCAAAACCCATCACAATGACACAGAGCTCATCAGAAAG
TTGAGAGAGGAGGGAAAAGTAATAGAACCTCTGAAAGATTTTCATAAAGATGAAGTGAGA
ATTTTGGGCAGAGAACTTGGACTTCCAGAAGAGTTAGTTTCCAGGCATCCATTTCCAGGT
CCTGGCCTGGCAATCAGAGTAATATGTGCTGAAGAACCTTATATTTGTAAGGACTTTCCT
GAAACCAACAATATTTTGAAAATAGTAGCTGATTTTTCTGCAAGTGTTAAAAAGCCACAT
ACCCTATTACAGAGAGTCAAAGCCTGCACAACAGAAGAGGATCAGGAGAAGCTGATGCAA
ATTACCAGTCTGCATTCACTGAATGCCTTCTTGCTGCCAATTAAAACTGTAGGTGTGCAG
GGTGACTGTCGTTCCTACAGTTACGTGTGTGGAATCTCCAGTAAAGATGAACCTGACTGG
GAATCACTTATTTTTCTGGCTAGGCTTATACCTCGCATGTGTCACAACGTTAACAGAGTT
GTTTATATATTTGGCCCACCAGTTAAAGAACCTCCTACAGATGTTACTCCCACTTTCTTG
ACAACAGGGGTGCTCAGTACTTTACGCCAAGCTGATTTTGAGGCCCATAACATTCTCAGG
GAGTCTGGGTATGCTGGGAAAATCAGCCAGATGCCGGTGATTTTGACACCATTACATTTT
GATCGGGACCCACTTCAAAAGCAGCCTTCATGCCAGAGATCTGTGGTTATTCGAACCTTT
ATTACTAGTGACTTCATGACTGGTATACCTGCAACACCTGGCAATGAGATCCCTGTAGAG
GTGGTATTAAAGATGGTCACTGAGATTAAGAAGATTCCTGGTATTTCTCGAATTATGTAT
GACTTAACATCAAAGCCCCCAGGAACTACTGAGTGGGAGTAA

# Metabolic_Enzyme_44_GenBank_ID_Gene:
U10860

# Metabolic_Enzyme_44_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_44_Locus:
3q24

# Metabolic_Enzyme_44_SNPs:
rs7637292; rs10936021; rs12496896; rs12634592; rs4680220; rs401514; rs7617878; rs4108611; rs3772117; rs7615287; rs7636930; rs6441023; rs4679757; rs2067877; rs6766927; rs12491178; rs1356252; rs7633168; rs6799267; rs12493764; rs3821365; rs6441028; rs9825321; rs2320318; rs12489430; rs7619976; rs6441027; rs12491537; rs6775044; rs7643525; rs12494730; rs6441024; rs6806109; rs6441026; rs12634282; rs12492258; rs3772116; rs6441022; rs6797289; rs7651038; rs12636569; rs2068601; rs9882341; rs3772112; rs10804774; rs12490114; rs11716272; rs12638836; rs4679756; rs406701; rs7430851; rs12497968; rs9883153; rs3772115; rs9819269; rs11712694; rs12495418; rs2874232; rs410042; rs9820541; rs6800992; rs7652005; rs6441025; rs11714133; rs9820534; rs6791517; rs3732399; rs12485735; rs10804773; rs12493422; rs12494104; rs12496313; rs1878213; rs9840456; rs13060931; rs7650106; rs1878211; rs12496006; rs3772113; rs10936020; rs9868194; rs12491896; rs11706359; rs6777776; rs35910218; rs11547948; rs35848656; rs11915364; rs34537819; rs28438758; rs12107883; rs13324534; rs35759331; rs12386360; rs386067; rs445758; rs35973380; rs4680221; rs12386362; rs35962523; rs35285447; rs11334499; rs35811525; rs13327285; rs10640770; rs6768724; rs7633729; rs12386359; rs4399846; rs3772114; rs35321137; rs34337666; rs7620397; rs35275341; rs12633671; rs33927918; rs11437800; rs35876194; rs35954197; rs9855091; rs35651046; rs35140614; rs4057812; rs34658682; rs35475067; rs9631467; rs35494199; rs9846097; rs13061643; rs9862051; rs35510283; rs34118890; rs35377438; rs11716666; rs36101569; rs35285525; rs12497735; rs34117696; rs34290186; rs34712245; rs34327298; rs35833112; rs35357023; rs41267913; rs35724165; rs12638792; rs35031753; rs34182099; rs11430855; rs1878212; rs12486102; rs10691429; rs9864005; rs35664957; rs11425774; rs34609350; rs10548751; rs7625201; rs36079607; rs7645121; rs7620712; rs12493409; rs10704428; rs35628034; rs9832621; rs7428956; rs4680219; rs34125997; rs28655132; rs35440885; rs34101828; rs4383470; rs12633670; rs11391424; rs5853733; rs11410318; rs35247619; rs35984925; rs12486189; rs35552128; rs35402685; rs10613824; rs11411886; rs35667159; rs5853732; rs35386649; rs33978589; rs12485698; rs12485701; rs12485742; rs12485802; rs12486864; rs12488351; rs12493934; rs12493963; rs12494143; rs12497838; rs1533443; rs16825554; rs2063903; rs2292716; rs4679758; rs4680222; rs819846

# Metabolic_Enzyme_44_General_References:
8089153

# Metabolic_Enzyme_44_References:
Not Available

# Metabolic_Enzyme_45_ID:
5865

# Metabolic_Enzyme_45_Name:
Ubiquitin-conjugating enzyme E2 E3

# Metabolic_Enzyme_45_Synonyms:
Ubiquitin-protein ligase E3; Ubiquitin carrier protein E3; Ubiquitin-conjugating enzyme E2-23 kDa; UbcH9; UbcM2

# Metabolic_Enzyme_45_Gene_Name:
UBE2E3

# Metabolic_Enzyme_45_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 E3
MSSDRQRSDDESPSTSSGSSDADQRDPAAPEPEEQEERKPSATQQKKNTKLSSKTTAKLS
TSAKRIQKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSSDY
PFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLV
GSIATQYLTNRAEHDRIARQWTKRYAT

# Metabolic_Enzyme_45_Number_of_Residues:
207

# Metabolic_Enzyme_45_Molecular_Weight:
22913

# Metabolic_Enzyme_45_Theoretical_pI:
7.25

# Metabolic_Enzyme_45_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_45_General_Function:
Not Available

# Metabolic_Enzyme_45_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest

# Metabolic_Enzyme_45_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_45_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_45_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_45_Signals:
None

# Metabolic_Enzyme_45_Transmembrane_Regions:
None

# Metabolic_Enzyme_45_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_45_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_45_GenBank_ID_Protein:
4586930

# Metabolic_Enzyme_45_SwissProt_ID:
UB2E3_HUMAN (Q969T4)

# Metabolic_Enzyme_45_swissprot_Name:
Not Available

# Metabolic_Enzyme_45_Genecard_id:
UBE2E3

# Metabolic_Enzyme_45_Geneatlas_id:
UBE2E3

# Metabolic_Enzyme_45_hgnc_id:
HGNC:12479

# Metabolic_Enzyme_45_PDB_ID:
Not Available

# Metabolic_Enzyme_45_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_45_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_45_Subcellular_Location:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner

# Metabolic_Enzyme_45_Gene_Sequence:
>624 bp
ATGTCCAGTGATAGGCAAAGGTCCGATGATGAGAGCCCCAGCACCAGCAGTGGCAGTTCA
GATGCGGACCAGCGAGACCCAGCCGCTCCAGAGCCTGAAGAACAAGAGGAAAGAAAACCT
TCTGCCACCCAGCAGAAGAAAAACACCAAACTCTCTAGCAAAACCACTGCTAAGTTATCC
ACTAGTGCTAAAAGAATTCAGAAGGAGCTAGCTGAAATAACCCTTGATCCTCCTCCTAAT
TGCAGTGCTGGGCCTAAAGGAGATAACATTTATGAATGGAGATCAACTATACTTGGTCCA
CCGGGTTCTGTATATGAAGGTGGTGTGTTTTTTCTGGATATCACATTTTCATCAGATTAT
CCATTTAAGCCACCAAAGGTTACTTTCCGCACCAGAATCTATCACTGCAACATCAACAGT
CAGGGAGTCATCTGTCTGGACATCCTTAAAGACAACTGGAGTCCCGCTTTGACTATTTCA
AAGGTTTTGCTGTCTATTTGTTCCCTTTTGACAGACTGCAACCCTGCGGATCCTCTGGTT
GGAAGCATAGCCACTCAGTATTTGACCAACAGAGCAGAACACGACAGGATAGCCAGACAG
TGGACCAAGAGATACGCAACATAA

# Metabolic_Enzyme_45_GenBank_ID_Gene:
AB017644

# Metabolic_Enzyme_45_Chromosome_Location:
Not Available

# Metabolic_Enzyme_45_Locus:
Not Available

# Metabolic_Enzyme_45_SNPs:
Not Available

# Metabolic_Enzyme_45_General_References:
10343118

# Metabolic_Enzyme_45_References:
Not Available

# Metabolic_Enzyme_46_ID:
5867

# Metabolic_Enzyme_46_Name:
Ubiquitin-conjugating enzyme E2 B

# Metabolic_Enzyme_46_Synonyms:
Ubiquitin-protein ligase B; Ubiquitin carrier protein B; HR6B; hHR6B; E2-17 kDa

# Metabolic_Enzyme_46_Gene_Name:
UBE2B

# Metabolic_Enzyme_46_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 
BMSTPARRRLMRDFKRLQEDPPVGVSGAPSENNIMQWNAVIFGPEGTPFEDGTFKLVIEF
SEEYPNKPPTVRFLSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPN
SPANSQAAQLYQENKREYEKRVSAIVEQSWNDS

# Metabolic_Enzyme_46_Number_of_Residues:
152

# Metabolic_Enzyme_46_Molecular_Weight:
17312

# Metabolic_Enzyme_46_Theoretical_pI:
4.64

# Metabolic_Enzyme_46_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_46_General_Function:
Not Available

# Metabolic_Enzyme_46_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA- associated PCNA on 'Lys-164'. May be involved in neurite outgrowth

# Metabolic_Enzyme_46_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_46_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_46_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_46_Signals:
None

# Metabolic_Enzyme_46_Transmembrane_Regions:
None

# Metabolic_Enzyme_46_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_46_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_46_GenBank_ID_Protein:
184046

# Metabolic_Enzyme_46_SwissProt_ID:
UBE2B_HUMAN (P63146)

# Metabolic_Enzyme_46_swissprot_Name:
Not Available

# Metabolic_Enzyme_46_Genecard_id:
UBE2B

# Metabolic_Enzyme_46_Geneatlas_id:
UBE2B

# Metabolic_Enzyme_46_hgnc_id:
HGNC:12473

# Metabolic_Enzyme_46_PDB_ID:
1JAS

# Metabolic_Enzyme_46_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_46_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_46_Subcellular_Location:
Cell membrane. Nucleus (By similarity). Note=In peripheral neurons, expressed both at the plasma membrane and in nuclei (By similarity)

# Metabolic_Enzyme_46_Gene_Sequence:
>459 bp
ATGTCGACCCCGGCCCGGAGGAGGCTCATGCGGGATTTCAAGCGGTTACAAGAGGACCCA
CCTGTGGGTGTCAGTGGCGCACCATCTGAAAACAACATCATGCAGTGGAATGCAGTTATA
TTTGGACCAGAAGGGACACCTTTTGAAGATGGTACTTTTAAACTAGTAATAGAATTTTCT
GAAGAATATCCAAATAAACCACCAACTGTTAGGTTTTTATCCAAAATGTTTCATCCAAAT
GTGTATGCTGATGGTAGCATATGTTTAGATATCCTTCAGAATCGATGGAGTCCAACATAT
GATGTATCTTCTATCTTAACATCAATTCAGTCTCTGCTGGATGAACCGAATCCTAACAGT
CCAGCCAATAGCCAGGCAGCACAGCTTTATCAGGAAAACAAACGAGAATATGAGAAAAGA
GTTTCGGCCATTGTTGAACAAAGCTGGAATGATTCATAA

# Metabolic_Enzyme_46_GenBank_ID_Gene:
M74525

# Metabolic_Enzyme_46_Chromosome_Location:
Not Available

# Metabolic_Enzyme_46_Locus:
Not Available

# Metabolic_Enzyme_46_SNPs:
Not Available

# Metabolic_Enzyme_46_General_References:
2158443; 1717990; 10908344

# Metabolic_Enzyme_46_References:
Not Available

# Metabolic_Enzyme_47_ID:
5605

# Metabolic_Enzyme_47_Name:
ADP-dependent glucokinase

# Metabolic_Enzyme_47_Synonyms:
ADPGK; ADP-GK; RbBP-35

# Metabolic_Enzyme_47_Gene_Name:
ADPGK

# Metabolic_Enzyme_47_Protein_Sequence:
>ADPdependent glucokinase
MALWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPPGPVSPEGRLAAA
WDALIVRPVRRWRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSILHSRNDLEEAFI
HFMGKGAAAERFFSDKETFHDIAQVASEFPGAQHYVGGNAALIGQKFAANSDLKVLLCGP
VGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWGQLKAPHANRFIFSHDLSNGAM
NMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVVTSISDIPTGIPVHLELAS
MTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLSSWNGVPDVGMVSDILF
WILKEHGRSKSRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETI
DTSRVSLRAPQEFMTSHSEAGSRIVLNPNKPVVEWHREGISFHFTPVLVCKDPIRTVGLG
DAISAEGLFYSEVHPHY

# Metabolic_Enzyme_47_Number_of_Residues:
497

# Metabolic_Enzyme_47_Molecular_Weight:
54089

# Metabolic_Enzyme_47_Theoretical_pI:
6.17

# Metabolic_Enzyme_47_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
 ||
>>>
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_47_General_Function:
Not Available

# Metabolic_Enzyme_47_Specific_Function:
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency

# Metabolic_Enzyme_47_Pathway:
Not Available

# Metabolic_Enzyme_47_Reaction:
ADP + D-glucose = AMP + D-glucose 6-phosphate

# Metabolic_Enzyme_47_Pfam_Domain_Function:
PF04587:ADP_PFK_GK

# Metabolic_Enzyme_47_Signals:
1-22

# Metabolic_Enzyme_47_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_47_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_47_EC_Link:
EC 2.7.1.147

# Metabolic_Enzyme_47_GenBank_ID_Protein:
16923351

# Metabolic_Enzyme_47_SwissProt_ID:
ADPGK_HUMAN (Q9BRR6)

# Metabolic_Enzyme_47_swissprot_Name:
Not Available

# Metabolic_Enzyme_47_Genecard_id:
ADPGK

# Metabolic_Enzyme_47_Geneatlas_id:
ADPGK

# Metabolic_Enzyme_47_hgnc_id:
HGNC:25250

# Metabolic_Enzyme_47_PDB_ID:
Not Available

# Metabolic_Enzyme_47_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_47_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_47_Subcellular_Location:
Not Available

# Metabolic_Enzyme_47_Gene_Sequence:
>1044 bp
ATGGGGAAGGGAGCAGCTGCTGAGCGCTTCTTCAGTGATAAGGAAACTTTTCACGACATT
GCCCAGGTTGCGTCAGAGTTCCCAGGAGCCCAGCACTATGTAGGAGGAAATGCAGCTTTA
ATTGGACAGAAATTTGCAGCCAACTCAGATTTAAAGGTTCTTCTTTGCGGTCCAGTTGGT
CCAAAGCTACATGAGCTTCTTGATGACAATGTCTTTGTTCCACCAGAGTCATTGCAGGAA
GTGGATGAGTTCCACCTCATTTTAGAGTATCAAGCAGGGGAGGAGTGGGGCCAGTTAAAA
GCTCCCCATGCCAACCGATTCATCTTCTCTCACGACCTCTCCAACGGGGCCATGAATATG
CTGGAGGTGTTTGTGTCTAGCCTGGAGGAGTTTCAGCCAGACCTGGTGGTCCTCTCTGGA
TTGCACATGATGGAGGGACAAAGCAAGGAGCTCCAGAGGAAGAGACTCTTGGAGGTTGTA
ACCTCCATTTCTGACATCCCCACTGGTATTCCAGTTCACCTAGAGCTGGCCAGTATGACT
AACAGGGAGCTCATGAGCAGCATTGTCCATCAGCAGGTCTTTCCCGCGGTGACTTCCCTT
GGGCTGAATGAACAGGAGCTGTTATTTCTCACCCAGTCAGCCTCTGGACCTCACTCTTCT
CTCTCTTCCTGGAACGGTGTTCCTGATGTGGGCATGGTCAGTGACATCCTCTTCTGGATC
TTGAAAGAACATGGGAGGAGTAAAAGCAGAGCCTCGGATCTCACCAGGATCCATTTCCAC
ACGCTGGTCTACCACATCCTGGCAACTGTGGATGGACACTGGGCCAACCAGCTGGCAGCC
GTGTTAGGAAGCTCGTGTGGCTGGGACACAGGCCTGCGCCACAGAAACCATAGACACCAG
CCGAGTGTCTCTGAGGGCACCCCAAGAGTTCATGACTTCCCATTCGGAGGCAGGCTCCAG
GATTGTATTAAACCCAAACAAGCCAGTAGTAGAATGGCACAGAGAGGGAATATCCTTCCA
CTTCACACCAGTATTGGTGTGTAA

# Metabolic_Enzyme_47_GenBank_ID_Gene:
AF204270

# Metabolic_Enzyme_47_Chromosome_Location:
Not Available

# Metabolic_Enzyme_47_Locus:
Not Available

# Metabolic_Enzyme_47_SNPs:
Not Available

# Metabolic_Enzyme_47_General_References:
11230166

# Metabolic_Enzyme_47_References:
Not Available

# Metabolic_Enzyme_48_ID:
5868

# Metabolic_Enzyme_48_Name:
Probable leucyl-tRNA synthetase, mitochondrial precursor

# Metabolic_Enzyme_48_Synonyms:
Leucine--tRNA ligase; LeuRS

# Metabolic_Enzyme_48_Gene_Name:
LARS2

# Metabolic_Enzyme_48_Protein_Sequence:
>Probable leucyltRNA synthetase, mitochondrial precursor
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVE
KWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGM
QVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPD
YYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQ
WFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYT
ATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVI
LAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQ
DAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVT
LPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPH
SPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIK
GQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGID
TIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNK
EKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDA
LCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQ
MAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFL
VQD

# Metabolic_Enzyme_48_Number_of_Residues:
903

# Metabolic_Enzyme_48_Molecular_Weight:
101977

# Metabolic_Enzyme_48_Theoretical_pI:
8.32

# Metabolic_Enzyme_48_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  leucine-tRNA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  leucyl-tRNA aminoacylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_48_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_48_Specific_Function:
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)

# Metabolic_Enzyme_48_Pathway:
map00290  Valine, leucine and isoleucine biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_48_Reaction:
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)

# Metabolic_Enzyme_48_Pfam_Domain_Function:
PF08264:Anticodon_1;
PF00133:tRNA-synt_1;
PF09334:tRNA-synt_1g

# Metabolic_Enzyme_48_Signals:
None

# Metabolic_Enzyme_48_Transmembrane_Regions:
None

# Metabolic_Enzyme_48_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_48_EC_Link:
EC 6.1.1.4

# Metabolic_Enzyme_48_GenBank_ID_Protein:
40788954

# Metabolic_Enzyme_48_SwissProt_ID:
SYLM_HUMAN (Q15031)

# Metabolic_Enzyme_48_swissprot_Name:
Not Available

# Metabolic_Enzyme_48_Genecard_id:
LARS2

# Metabolic_Enzyme_48_Geneatlas_id:
LARS2

# Metabolic_Enzyme_48_hgnc_id:
HGNC:17095

# Metabolic_Enzyme_48_PDB_ID:
Not Available

# Metabolic_Enzyme_48_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_48_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_48_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_48_Gene_Sequence:
>2715 bp
AGAATGGCTTCTGTTTGGCAGAGATTGGGTTTTTATGCCTCTCTTCTGAAAAGACAGCTA
AATGGTGGGCCAGATGTCATCAAGTGGGAAAGGAGAGTAATTCCCGGATGTACCAGAAGC
ATCTACAGTGCCACGGGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTT
GAGAAATGGTGGCATCAACGAATAAAAGAACAGGCCTCCAAAATTTCAGAAGCTGATAAA
TCGAAGCCAAAATTTTACGTGCTTTCCATGTTCCCTTATCCTTCTGGTAAGCTGCACATG
GGCCATGTGCGTGTCTACACCATCAGCGACACCATAGCACGGTTCCAGAAGATGAGAGGG
ATGCAGGTCATCAACCCCATGGGATGGGATGCTTTTGGATTGCCTGCTGAAAATGCCGCA
GTCGAGAGGAATCTACATCCACAAAGTTGGACACAAAGTAATATTAAACACATGAGGAAA
CAGCTTGATCGTCTGGGCCTGTGTTTCAGCTGGGATAGGGAAATAACTACGTGTTTGCCA
GATTACTACAAGTGGACTCAGTATCTCTTTATTAAACTGTATGAGGCTGGGCTGGCCTAT
CAAAAGGAGGCCCTGGTTAACTGGGACCCAGTGGATCAAACAGTGCTTGCCAATGAGCAG
GTGGATGAACATGGCTGTTCATGGCGTTCTGGAGCAAAGGTGGAACAGAAGTACCTCAGA
CAATGGTTTATTAAGACAACCGCTTATGCAAAGGCCATGCAGGACGCGTTGGCAGACCTT
CCAGAATGGTATGGAATAAAAGGCATGCAAGCCCACTGGATTGGGGACTGTGTGGGCTGC
CACCTGGACTTCACATTAAAGGTTCATGGGCAAGCCACGGGCGAAAAGCTGACTGCCTAT
ACGGCCACCCCTGAAGCCATTTATGGCACCTCCCACGTGGCCATCTCGCCCAGCCACAGA
CTCCTACATGGGCACAGCTCTCTGAAGGAAGCCTTGAGGATGGCCCTTGTCCCTGGCAAA
GATTGCCTCACGCCTGTAATGGCTGTGAACATGCTTACCCAGCAGGAGGTCCCTGTCGTT
ATTTTGGCCAAAGCTGACTTGGAAGGCTCTCTGGATTCAAAAATAGGAATTCCCAGTACT
AGCTCAGAGGACACCATCTTAGCCCAAACCCTGGGCCTGGCCTACTCTGAAGTCATTGAA
ACTTTGCCAGATGGCACAGAGAGACTGAGCAGCTCTGCTGAGTTCACAGGTATGACCCGG
CAGGATGCTTTTCTAGCCCTGACTCAGAAAGCCCGGGGGAAGAGAGTGGGTGGAGACGTG
ACAAGTGATAAACTGAAAGACTGGCTGATTTCACGGCAGCGGTACTGGGGCACACCAATC
CCCATTGTCCACTGCCCAGTCTGTGGCCCCACACCTGTGCCCCTGGAGGACTTGCCTGTG
ACCCTGCCCAACATCGCGTCTTTCACTGGCAAGGGAGGCCCCCCACTGGCCATGGCTTCA
GAGTGGGTGAACTGCTCCTGCCCAAGGTGCAAGGGAGCAGCCAAGAGAGAGACAGACACG
ATGGATACCTTTGTTGATTCTGCTTGGTACTACTTCAGATACACTGACCCTCATAATCCA
CACAGCCCTTTTAACACAGCAGTGGCCGATTACTGGATGCCTGTGGATTTGTACATTGGA
GGGAAAGAACATGCCGTCATGCACTTGTTCTATGCAAGATTCTTTAGTCATTTTTGCCAT
GATCAAAAAATGGTTAAACATAGGGAGCCTTTTCATAAGCTGCTGGCCCAAGGCCTTATC
AAGGGGCAGACATTCCGCCTACCATCTGGACAGTATCTACAGAGAGAGGAAGTGGATCTC
ACAGGTTCCGTTCCTGTTCATGCAAAAACGAAAGAGAAGTTAGAGGTGACGTGGGAGAAG
ATGAGTAAGTCCAAACACAACGGGGTGGACCCAGAGGAAGTTGTGGAGCAGTATGGGATC
GACACGATTCGGCTCTACATCCTTTTTGCTGCCCCTCCTGAGAAGGATATCTTGTGGGAT
GTGAAAACTGATGCTCTCCCTGGGGTGCTGAGATGGCAACAACGACTGTGGACCTTGACA
ACTCGGTTTATTGAGGCCAGGGCTTCTGGGAAGTCTCCCCAGCCTCAGCTGCTGAGTAAC
AAGGAGAAAGCTGAGGCCAGGAAGCTCTGGGAGTACAAGAACTCCGTCATCTCTCAGGTG
ACCACCCATTTCACAGAGGACTTCTCACTGAATTCTGCAATTTCTCAGCTGATGGGACTC
AGCAATGCCCTCTCGCAAGCCTCTCAGAGCGTCATTCTCCACAGCCCCGAGTTTGAGGAT
GCTTTGTGTGCCCTGATGGTAATGGCTGCTCCACTGGCCCCTCATGTAACCTCAGAGATC
TGGGCAGGCCTGGCGCTGGTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCAGT
GTGCTGCTCCAGGCATGGCCTGCTGTGGACCCGGAGTTCCTGCAGCAGCCTGAGGTTGTC
CAGATGGCAGTTCTGATCAACAATAAAGCTTGTGGCAAAATTCCTGTGCCCCAACAAGTT
GCCCGGGACCAGGACAAAGTCCACGAATTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTT
TTGCAAGGACGAAGCATCAAGAAGTCCTTCCTTTCCCCGAGAACTGCCCTCATCAACTTC
CTGGTGCAAGATTGA

# Metabolic_Enzyme_48_GenBank_ID_Gene:
D21851

# Metabolic_Enzyme_48_Chromosome_Location:
Not Available

# Metabolic_Enzyme_48_Locus:
Not Available

# Metabolic_Enzyme_48_SNPs:
Not Available

# Metabolic_Enzyme_48_General_References:
7584026

# Metabolic_Enzyme_48_References:
Not Available

# Metabolic_Enzyme_49_ID:
5869

# Metabolic_Enzyme_49_Name:
AMP deaminase 3

# Metabolic_Enzyme_49_Synonyms:
AMP deaminase isoform E; Erythrocyte AMP deaminase

# Metabolic_Enzyme_49_Gene_Name:
AMPD3

# Metabolic_Enzyme_49_Protein_Sequence:
>AMP deaminase 3
MPRQFPKLNISEVDEQVRLLAEKVFAKVLREEDSKDALSLFTVPEDCPIGQKEAKERELQ
KELAEQKSVETAKRKKSFKMIRSQSLSLQMPPQQDWKGPPAASPAMSPTTPVVTGATSLP
TPAPYAMPEFQRVTISGDYCAGITLEDYEQAAKSLAKALMIREKYARLAYHRFPRITSQY
LGHPRADTAPPEEGLPDFHPPPLPQEDPYCLDDAPPNLDYLVHMQGGILFVYDNKKMLEH
QEPHSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKEL
KSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFD
GLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARM
VKEVARELEESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKVYSPNMRWIIQVPRIYDIF
RSKKLLPNFGKMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDK
SPNPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAF
LTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSL
STDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYY
KEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITALTN

# Metabolic_Enzyme_49_Number_of_Residues:
767

# Metabolic_Enzyme_49_Molecular_Weight:
88813

# Metabolic_Enzyme_49_Theoretical_pI:
6.98

# Metabolic_Enzyme_49_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  AMP deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_49_General_Function:
Not Available

# Metabolic_Enzyme_49_Specific_Function:
AMP deaminase plays a critical role in energy metabolism

# Metabolic_Enzyme_49_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_49_Reaction:
AMP + H2O = IMP + ammonia

# Metabolic_Enzyme_49_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_49_Signals:
None

# Metabolic_Enzyme_49_Transmembrane_Regions:
None

# Metabolic_Enzyme_49_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_49_EC_Link:
EC 3.5.4.6

# Metabolic_Enzyme_49_GenBank_ID_Protein:
219457

# Metabolic_Enzyme_49_SwissProt_ID:
AMPD3_HUMAN (Q01432)

# Metabolic_Enzyme_49_swissprot_Name:
Not Available

# Metabolic_Enzyme_49_Genecard_id:
AMPD3

# Metabolic_Enzyme_49_Geneatlas_id:
AMPD3

# Metabolic_Enzyme_49_hgnc_id:
HGNC:470

# Metabolic_Enzyme_49_PDB_ID:
Not Available

# Metabolic_Enzyme_49_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_49_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_49_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_49_Gene_Sequence:
>2304 bp
ATGCCGCGGCAGTTTCCCAAGCTGAACATCTCTGAAGTGGATGAGCAAGTCCGGCTCCTG
GCGGAGAAGGTGTTTGCTAAAGTGCTCCGAGAAGAGGACAGCAAAGATGCCCTGTCCCTG
TTCACTGTCCCAGAGGACTGCCCCATCGGGCAAAAGGAAGCCAAGGAGAGGGAGCTGCAG
AAGGAGCTGGCAGAGCAGAAGTCTGTGGAGACCGCAAAAAGAAAGAAAAGTTTCAAGATG
ATTCGGTCCCAGTCCCTGTCTCTGCAAATGCCGCCACAGCAAGATTGGAAGGGCCCCCCG
GCAGCCAGTCCGGCCATGTCTCCCACAACCCCTGTGGTCACTGGAGCCACTTCCCTGCCC
ACGCCAGCACCCTATGCCATGCCTGAGTTCCAGCGGGTCACCATCAGCGGAGATTACTGT
GCCGGGATCACTTTGGAGGACTATGAGCAGGCAGCCAAGAGTCTGGCCAAGGCCCTAATG
ATCCGGGAGAAGTATGCGCGGCTCGCCTACCACCGCTTCCCGCGGATCACATCCCAGTAC
CTGGGTCATCCGCGGGCGGATACTGCACCTCCGGAAGAGGGCCTTCCAGACTTCCACCCT
CCTCCACTGCCCCAGGAAGACCCCTACTGCCTGGATGATGCACCCCCCAACCTGGATTAC
TTGGTCCACATGCAGGGGGGCATCCTCTTTGTGTATGATAACAAGAAGATGCTGGAGCAC
CAGGAGCCGCACAGCCTACCCTACCCCGACCTGGAGACCTACACGGTGGACATGAGCCAC
ATCCTGGCTCTCATCACCGATGGCCCCACGAAAACCTATTGTCACCGGCGACTGAACTTT
CTGGAATCCAAGTTCAGCCTTCATGAGATGTTAAACGAAATGTCCGAGTTCAAAGAGTTG
AAGAGTAACCCCCACCGGGACTTCTATAACGTGAGAAAGGTGGACACACACATCCATGCG
GCCGCCTGCATGAACCAAAAGCATCTGCTGCGCTTCATCAAGCACACATACCAGACGGAG
CCTGACAGGACTGTGGCAGAGAAGCGGGGCCGGAAGATCACCCTGCGGCAGGTGTTTGAC
GGCCTGCACATGGACCCCTACGACCTCACTGTGGACTCACTGGATGTCCACGCGGGCCGG
CAGACATTCCACCGCTTTGACAAGTTCAACTCCAAATACAACCCTGTGGGGGCCAGTGAG
CTGCGTGACCTGTATTTGAAAACTGAAAACTATCTGGGAGGAGAGTACTTTGCTCGGATG
GTCAAGGAGGTTGCCCGGGAGCTGGAGGAGAGCAAGTACCAGTACTCAGAGCCACGGCTC
TCCATCTACGGCCGCAGTCCTGAGGAGTGGCCCAACCTGGCCTACTGGTTCATCCAGCAC
AAGGTCTACTCTCCCAACATGCGCTGGATCATCCAGGTGCCCCGGATTTATGACATATTT
AGGTCAAAGAAGCTGCTGCCAAACTTTGGGAAGATGCTGGAGAACATCTTCCTGCCCCTT
TTCAAGGCCACTATCAACCCCCAAGATCATCGAGAGCTTCACCTCTTCCTTAAATATGTG
ACGGGGTTTGACAGCGTGGATGATGAGTCCAAGCACAGCGACCACATGTTTTCCGACAAG
AGCCCAAACCCGGACGTCTGGACCAGTGAGCAGAACCCACCCTACAGCTACTACCTGTAC
TACATGTATGCCAACATCATGGTGCTCAACAACCTCCGCAGGGAGCGCGGCCTGAGCACG
TTCCTGTTCCGGCCGCACTGTGGGGAAGCCGGCTCCATCACCCACCTGGTGTCTGCCTTC
CTCACTGCTGACAACATTTCCCACGGGCTGCTCCTCAAGAAGAGTCCGGTATTGCAGTAT
CTCTACTACCTTGCTCAGATCCCCATTGCCATGTCTCCTCTTAGCAACAACAGTTTGTTC
CTCGAATATTCCAAGAACCCTCTGAGGGAATTCCTACACAAGGGACTGCATGTTTCTCTT
TCCACCGATGACCCCATGCAGTTCCACTACACGAAGGAAGCACTTATGGAAGAATATGCC
ATTGCAGCTCAAGTGTGGAAGCTGAGCACCTGCGACCTGTGTGAGATCGCCAGGAACAGC
GTGCTGCAGAGCGGCCTCTCGCATCAGGAAAAGCAAAAGTTTCTGGGACAAAATTATTAT
AAAGAAGGACCTGAAGGAAATGATATTCGAAAGACAAATGTGGCTCAGATCCGGATGGCA
TTCCGATATGAGACCTTATGCAATGAGCTCAGCTTCCTGTCTGATGCTATGAAATCAGAA
GAGATCACCGCCTTGACCAACTAG

# Metabolic_Enzyme_49_GenBank_ID_Gene:
D12775

# Metabolic_Enzyme_49_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_49_Locus:
11p15

# Metabolic_Enzyme_49_SNPs:
rs11042836; rs36003153; rs3741041; rs16907852; rs34319136; rs11820856; rs899013; rs899011; rs899010; rs1037998; rs936513; rs936514; rs9292; rs1545743; rs7109334; rs11822997; rs930672; rs7416; rs2071020; rs7123980; rs7124144; rs2071019; rs1466426; rs2071018; rs7113101; rs1001118; rs7122280; rs11042840; rs10840419; rs3741037; rs10437597; rs10840427; rs3891547; rs2071017; rs11826750; rs10840429; rs11042854; rs12419888; rs12795565; rs11042830; rs10770120; rs11042841; rs3802917; rs11042846; rs3741038; rs11602933; rs11042853; rs7943804; rs11042849; rs17401498; rs7105307; rs11601268; rs7128132; rs12271597; rs11042855; rs11042833; rs4910146; rs7107588; rs7125606; rs12416948; rs6484336; rs4910140; rs10840424; rs11042850; rs16907878; rs11042842; rs10840425; rs11042834; rs16907858; rs11042828; rs11042848; rs899014; rs11042856; rs7127884; rs1466427; rs7124537; rs10770122; rs7934278; rs2071016; rs7125888; rs10840431; rs4910143; rs11042832; rs11042851; rs12800954; rs12284970; rs4910141; rs11042864; rs6484302; rs7934815; rs11042839; rs16907891; rs12421214; rs16907836; rs16907914; rs16907919; rs10840428; rs3741043; rs7110563; rs3741039; rs11042831; rs4910144; rs4909930; rs10770119; rs7114333; rs17310342; rs11042852; rs12290824; rs7949917; rs10840420; rs11042859; rs11042843; rs7944154; rs4909932; rs10840430; rs11042847; rs16907868; rs7101748; rs10840422; rs922360; rs10770118; rs10840421; rs16907909; rs16907896; rs7130140; rs16907917; rs7101934; rs11042835; rs12418145; rs11042844; rs11042863; rs10840423; rs7932321; rs4909931; rs7950039; rs4909928; rs7929999; rs4909929; rs7111970; rs12161765; rs6484290; rs7112321; rs6484291; rs4910139; rs3741040; rs12418097; rs1803101; rs416372; rs11278140; rs10592594; rs34205084; rs10666578; rs376859; rs35285382; rs35234722; rs34276239; rs2403330; rs433847; rs35548473; rs922359; rs35027484; rs5029459; rs34686247; rs11042817; rs2169594; rs36117985; rs28403593; rs12360830; rs35815414; rs28403594; rs35417007; rs34947038; rs11042816; rs34448488; rs34793322; rs11455471; rs7120456; rs12804742; rs35753139; rs12789944; rs12295824; rs35307925; rs35469290; rs11042827; rs11042815; rs12285554; rs10770121; rs11042837; rs10437667; rs389793; rs4909933; rs12291731; rs411593; rs12291443; rs7937616; rs11042857; rs12295125; rs5789638; rs11042813; rs34796012; rs34400211; rs10466517; rs11327316; rs35172583; rs12284303; rs10466406; rs12287821; rs36106536; rs7107965; rs11042812; rs35535464; rs36075284; rs12271609; rs446512; rs11042826; rs10466515; rs12221503; rs12293113; rs10840426; rs11042845; rs10743142; rs11042862; rs403952; rs34388590; rs34972496; rs34843534; rs12790244; rs7119606; rs11522665; rs10466514; rs12292471; rs35410520; rs12575256; rs12786914; rs12224969; rs12287504; rs35022461; rs35501680; rs34957142; rs4910142; rs12184411; rs11042860; rs16907904; rs35803105; rs34769794; rs34045306; rs35148074; rs11346179; rs11042838; rs34159907; rs4910147; rs11279688; rs34735568; rs35724616; rs10466404; rs35916834; rs7937988; rs35909829; rs12803441; rs4909934; rs4369398; rs7951269; rs11042861; rs34779745; rs34942282; rs11530493; rs11820349; rs9736934; rs11042829; rs35114038; rs10466516; rs12802491; rs12284175; rs10709823; rs11042818; rs36119682; rs35629432; rs11042858; rs12291294; rs34456454; rs36120251; rs11042814; rs11042811; rs11042825; rs36032769; rs7107565; rs7937289; rs7107698; rs7124271; rs10643285; rs36206458; rs8181594; rs7938316; rs11042810; rs10590775; rs1043778; rs10500725; rs1074375; rs10770123; rs10840415; rs10840416; rs10840417; rs10840418; rs11042805; rs11042806; rs11042865; rs11042866; rs11042867; rs11042868; rs11602469; rs11607008; rs12164827; rs12225339; rs12280618; rs12290357; rs12363993; rs12448; rs12789639; rs16907826; rs1870951; rs3177103; rs3741036; rs374925; rs382044; rs383090; rs394242; rs411783; rs4146830; rs428325; rs446762; rs4910149; rs4910150; rs570362; rs6484281; rs677322; rs7119498; rs7939845; rs7948437; rs899012; rs9971562

# Metabolic_Enzyme_49_General_References:
1420359; 1400401; 8611627; 8004104

# Metabolic_Enzyme_49_References:
Not Available

# Metabolic_Enzyme_50_ID:
5870

# Metabolic_Enzyme_50_Name:
Ubiquitin-conjugating enzyme E2 J2

# Metabolic_Enzyme_50_Synonyms:
Non-canonical ubiquitin-conjugating enzyme 2; NCUBE2

# Metabolic_Enzyme_50_Gene_Name:
UBE2J2

# Metabolic_Enzyme_50_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 J2
MNSTSSKRAPTTATQRLKQDYLRIKKDPVPYICAEPLPSNILEWHYVVRGPEMTPYEGGY
YHGKLIFPREFPFKPPSIYMITPNGRFKCNTRLCLSITDFHPDTWNPAWSVSTILTGLLS
FMVEKGPTLGSIETSDFTKRQLAVQSLAFNLKDKVFCELFPEVVEEIKQKQKAQDELSSR
PQTLPLPDVVPDGETHLVQNGIQLLNGHAPGAVPNLAGLQQANRHHGLLGGALANLFVIV
GFAAFAYTVKYVLRSIAQE

# Metabolic_Enzyme_50_Number_of_Residues:
259

# Metabolic_Enzyme_50_Molecular_Weight:
28926

# Metabolic_Enzyme_50_Theoretical_pI:
8.59

# Metabolic_Enzyme_50_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_50_General_Function:
Not Available

# Metabolic_Enzyme_50_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum

# Metabolic_Enzyme_50_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_50_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_50_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_50_Signals:
None

# Metabolic_Enzyme_50_Transmembrane_Regions:
227-247

# Metabolic_Enzyme_50_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_50_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_50_GenBank_ID_Protein:
14029267

# Metabolic_Enzyme_50_SwissProt_ID:
UB2J2_HUMAN (Q8N2K1)

# Metabolic_Enzyme_50_swissprot_Name:
Not Available

# Metabolic_Enzyme_50_Genecard_id:
UBE2J2

# Metabolic_Enzyme_50_Geneatlas_id:
UBE2J2

# Metabolic_Enzyme_50_hgnc_id:
HGNC:19268

# Metabolic_Enzyme_50_PDB_ID:
Not Available

# Metabolic_Enzyme_50_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_50_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_50_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass type IV membrane protein

# Metabolic_Enzyme_50_Gene_Sequence:
>777 bp
ATGAGCAGCACCAGCAGTAAGAGGGCTCCGACCACGGCAACCCAGAGGCTGAAGCAGGAC
TACCTTCGCATTAAGAAAGACCCGGTGCCTTACATCTGTGCCGAGCCCCTCCCTTCGAAT
ATTCTCGAGTGGCACTATGTCGTCCGAGGCCCAGAGATGACCCCTTATGAAGGTGGCTAT
TATCATGGAAAACTAATTTTTCCCAGAGAATTTCCTTTCAAACCTCCCAGTATCTATATG
ATCACTCCCAACGGGAGGTTTAAGTGCAACACCAGGCTGTGTCTTTCTATCACGGATTTC
CACCCGGACACGTGGAACCCGGCCTGGTCTGTCTCCACCATCCTGACTGGGCTCCTGAGC
TTCATGGTGGAGAAGGGCCCCACCCTGGGCAGTATAGAGACGTCGGACTTCACGAAAAGA
CAACTGGCAGTGCAGAGTTTAGCATTTAATTTGAAAGATAAAGTCTTTTGTGAATTATTT
CCTGAAGTCGTGGAGGAGATTAAACAAAAACAGAAAGCACAAGACGAACTCAGTAGCAGA
CCCCAGACTCTCCCCTTGCCAGACGTGGTTCCAGACGGGGAGACGCACCTCGTCCAGAAC
GGGATTCAGCTGCTCAACGGGCATGCGCCGGGGGCCGTCCAAACCTCGCAGGGCTCCAGC
AGGCCAACCGGCACCACGGACTCTGGGTGGCGCCCTGGCGAACTTGTTTGTATAGTTGGG
TTTGCAGCCTTTGCTTACACGGTCAAGTACGTGCTGAGGAGCATCGCGCAGGAGTGA

# Metabolic_Enzyme_50_GenBank_ID_Gene:
AF296658

# Metabolic_Enzyme_50_Chromosome_Location:
Not Available

# Metabolic_Enzyme_50_Locus:
Not Available

# Metabolic_Enzyme_50_SNPs:
Not Available

# Metabolic_Enzyme_50_General_References:
11278356

# Metabolic_Enzyme_50_References:
Not Available

# Metabolic_Enzyme_51_ID:
5871

# Metabolic_Enzyme_51_Name:
AMP deaminase 2

# Metabolic_Enzyme_51_Synonyms:
AMP deaminase isoform L

# Metabolic_Enzyme_51_Gene_Name:
AMPD2

# Metabolic_Enzyme_51_Protein_Sequence:
>AMP deaminase 2
MRNRGQGLFRLRSRCFLHQSLPLGAGRRKGLDVAEPGPSRCRSDSPAVAAVVPAMASYPS
GSGKPKAKYPFKKRASLQASTAAPEARGGLGAPPLQSARSLPGPAPCLKHFPLDLRTSMD
GKCKEIAEELFTRSLAESELRSAPYEFPEESPIEQLEERRQRLERQISQDVKLEPDILLR
AKQDFLKTDSDSDLQLYKEQGEGQGDRSLRERDVLEREFQRVTISGEEKCGVPFTDLLDA
AKSVVRALFIREKYMALSLQSFCPTTRRYLQQLAEKPLETRTYEQGPDTPVSADAPVHPP
ALEQHPYEHCEPSTMPGDLGLGLRMVRGVVHVYTRREPDEHCSEVELPYPDLQEFVADVN
VLMALIINGPIKSFCYRRLQYLSSKFQMHVLLNEMKELAAQKKVPHRDFYNIRKVDTHIH
ASSCMNQKHLLRFIKRAMKRHLEEIVHVEQGREQTLREVFESMNLTAYDLSVDTLDVHAD
RNTFHRFDKFNAKYNPIGESVLREIFIKTDNRVSGKYFAHIIKEVMSDLEESKYQNAELR
LSIYGRSRDEWDKLARWAVMHRVHSPNVRWLVQVPRLFDVYRTKGQLANFQEMLENIFLP
LFEATVHPASHPELHLFLEHVDGFDSVDDESKPENHVFNLESPLPEAWVEEDNPPYAYYL
YYTFANMAMLNHLRRQRGFHTFVLRPHCGEAGPIHHLVSAFMLAENISHGLLLRKAPVLQ
YLYYLAQIGIAMSPLSNNSLFLSYHRNPLPEYLSRGLMVSLSTDDPLQFHFTKEPLMEEY
SIATQVWKLSSCDMCELARNSVLMSGFSHKVKSHWLGPNYTKEGPEGNDIRRTNVPDIRV
GYRYETLCQELALITQAVQSEMLETIPEEAGITMSPGPQ

# Metabolic_Enzyme_51_Number_of_Residues:
879

# Metabolic_Enzyme_51_Molecular_Weight:
100689

# Metabolic_Enzyme_51_Theoretical_pI:
6.93

# Metabolic_Enzyme_51_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  AMP deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_51_General_Function:
Not Available

# Metabolic_Enzyme_51_Specific_Function:
AMP deaminase plays a critical role in energy metabolism

# Metabolic_Enzyme_51_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_51_Reaction:
AMP + H2O = IMP + ammonia

# Metabolic_Enzyme_51_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_51_Signals:
None

# Metabolic_Enzyme_51_Transmembrane_Regions:
None

# Metabolic_Enzyme_51_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_51_EC_Link:
EC 3.5.4.6

# Metabolic_Enzyme_51_GenBank_ID_Protein:
644509

# Metabolic_Enzyme_51_SwissProt_ID:
AMPD2_HUMAN (Q01433)

# Metabolic_Enzyme_51_swissprot_Name:
Not Available

# Metabolic_Enzyme_51_Genecard_id:
AMPD2

# Metabolic_Enzyme_51_Geneatlas_id:
AMPD2

# Metabolic_Enzyme_51_hgnc_id:
HGNC:469

# Metabolic_Enzyme_51_PDB_ID:
Not Available

# Metabolic_Enzyme_51_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_51_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_51_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_51_Gene_Sequence:
>2263 bp
CGCCGAGGAGCTGTTCACCCGCTCACTGGCTGAGAGCGAGCTCCGTAGTGCCCCGTATGA
GTTCCCCGAGGAGAGCCCCATTGAACAGCTGGAGGAGCGGCGGCAGCGGCTGGAGCGGCA
GATCAGCCAGGATGTCAAGCTGGAGCCAGACATCCTGCTTCGGGCCAAGCAAGATTTCCT
GAAGACGGACAGTGACTCGGACCTACAGCTCTACAAGGAACAGGGTGAGGGGCAGGGTGA
CCGGAGCCTGCGGGAGCGTGATGTGCTGGAACGGGAGTTTCAGCGGGTCACCATCTCTGG
GGAGGAGAAGTGTGGGGTGCCGTTCACAGACCTGCTGGATGCAGCCAAGAGTGTGGTGCG
GGCGCTCTTCATCCGGGAGAAGTACATGGCCCTGTCCCTGCAGAGCTTCTGCCCCACCAC
CCGCCGCTACCTGCAGCAGCTGGCTGAAAAGCCTCTGGAGACCCGGACCTATGAACAGGG
CCCCGACACCCCTGTGTCTGCTGATGCCCCGGTGCACCCCCCTGCGCTGGAGCAGCACCC
GTATGAGCACTGTGAGCCAAGCACCATGCCTGGGGACCTGGGCTTGGGTCTGCGCATGGT
GCGGGGTGTGGTGCACGTCTACACCCGCAGGGAACCCGACGAGCATTGCTCAGAGGTGGA
GCTGCCATACCCTGACCTGCAGGAATTTGTGGCTGACGTCAATGTGCTGATGGCCCTGAT
TATCAATGGCCCCATAAAGTCATTCTGCTACCGCCGGCTGCAGTACCTGAGCTCCAAGTT
CCAGATGCATGTGCTACTCAATGAGATGAAGGAGCTGGCCGCCCAGAAGAAAGTGCCACA
CCGAGATTTCTACAACATCCGCAAGGTGGACACCCACATCCATGCCTCGTCCTGCATGAA
CCAGAAGCATCTGCTGCGCTTCATCAAGCGGGCAATGAAGCGGCACCTGGAGGAGATCGT
GCACGTGGAGCAGGGCCGTGAACAGACGCTGCGGGAGGTCTTTGAGAGCATGAATCTCAC
GGCCTACGACCTGAGTGTGGACACGCTGGATGTGCATGCGGACAGGAACACTTTCCATCG
CTTTGACAAGTTTAATGCCAAATACAACCCTATTGGGGAGTCCGTCCTCCGAGAGATCTT
CATCAAGACGGACAACAGGGTATCTGGGAAGTACTTTGCTCACATCATCAAGGAGGTGAT
GTCAGACCTGGAGGAGAGCAAATACCAGAATGCAGAGCTGCGGCTCTCCATTTACGGGCG
CTCGAGGGATGAGTGGGACAAGCTGGCGCGCTGGGCCGTCATGCACCGCGTGCACTCCCC
CAACGTGCGCTGGCTGGTGCAGGTGCCCCGCCTCTTTGATGTGTACCGTACCAAGGGCCA
GCTGGCCAACTTCCAGGAGATGCTGGAGAACATCTTCCTGCCACTGTTCGAGGCCACTGT
GCACCCTGCCAGCCACCCGGAACTGCATCTCTTCTTAGAGCACGTGGATGGTTTTGACAG
CGTGGATGATGAGTCCAAGCCTGAAAACCATGTCTTCAACCTGGAGAGCCCCCTGCCTGA
GGCGTGGGTGGAGGAGGACAACCCACCCTATGCCTACTACCTGTACTACACCTTTGCCAA
CATGGCCATGTTGAACCACCTGCGCAGGCAGAGGGGCTTCCACACGTTTGTGCTGAGGCC
ACACTGTGGGGAGGCTGGGCCCATCCACCACCTGGTGTCAGCCTTCATGCTGGCTGAGAA
CATTTCCCACGGGCTCCTTCTGCGCAAGGCCCCCGTCCTGCAGTACCTGTACTACCTGGC
CCAGATCGGCATCGCCATGTCTCCGCTCAGCAACAACAGCCTCTTCCTCAGCTATCACCG
GAATCCGCTACCGGAGTACCTGTCCCGCGGCCTCATGGTCTCCCTGTCCACTGATGATCC
CTTGCAGTTCCACTTCACCAAGGAGCCGCTGATGGAGGAGTACAGCATCGCCACCCAGGT
GTGGAAGCTCAGCTCCTGCGATATGTGTGAGCTGGCCCGCAACAGCGTGCTCATGAGCGG
CTTCTCGCACAAGGTAAAGAGCCACTGGCTGGGACCCAACTATACCAAGGAAGGCCCTGA
GGGGAATGACATCCGCCGGACCAATGTGCCAGACATCCGCGTGGGCTACCGCTACGAGAC
CCTGTGCCAGGAGCTGGCGCTCATCACGCAGGCAGTCCAGAGTGAGATGCTGGAGACCAT
TCCAGAGGAGGCGGGTATCACCATGAGCCCAGGGCCTCAATGA

# Metabolic_Enzyme_51_GenBank_ID_Gene:
M91029

# Metabolic_Enzyme_51_Chromosome_Location:
Not Available

# Metabolic_Enzyme_51_Locus:
Not Available

# Metabolic_Enzyme_51_SNPs:
Not Available

# Metabolic_Enzyme_51_General_References:
1429593; 8526848; 8764830

# Metabolic_Enzyme_51_References:
Not Available

# Metabolic_Enzyme_52_ID:
5872

# Metabolic_Enzyme_52_Name:
cGMP-inhibited 3',5'-cyclic phosphodiesterase A

# Metabolic_Enzyme_52_Synonyms:
Cyclic GMP-inhibited phosphodiesterase A; CGI-PDE A

# Metabolic_Enzyme_52_Gene_Name:
PDE3A

# Metabolic_Enzyme_52_Protein_Sequence:
>cGMPinhibited 3',5'cyclic phosphodiesterase 
AMAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSR
KLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGA
PGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLG
VGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPY
LAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAE
MSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITD
LLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKL
AIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSW
NNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLV
SKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPAD
EPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTY
APETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLF
EDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVI
NDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYD
HPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRF
LVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKE
LHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSA
GLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHL
LQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKP
DQ

# Metabolic_Enzyme_52_Number_of_Residues:
1141

# Metabolic_Enzyme_52_Molecular_Weight:
124980

# Metabolic_Enzyme_52_Theoretical_pI:
5.87

# Metabolic_Enzyme_52_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_52_General_Function:
Not Available

# Metabolic_Enzyme_52_Specific_Function:
Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP)

# Metabolic_Enzyme_52_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_52_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_52_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_52_Signals:
None

# Metabolic_Enzyme_52_Transmembrane_Regions:
61-83; 129-151; 158-180; 184-206; 238-255

# Metabolic_Enzyme_52_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_52_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_52_GenBank_ID_Protein:
38201493

# Metabolic_Enzyme_52_SwissProt_ID:
PDE3A_HUMAN (Q14432)

# Metabolic_Enzyme_52_swissprot_Name:
Not Available

# Metabolic_Enzyme_52_Genecard_id:
PDE3A

# Metabolic_Enzyme_52_Geneatlas_id:
PDE3A

# Metabolic_Enzyme_52_hgnc_id:
HGNC:8778

# Metabolic_Enzyme_52_PDB_ID:
Not Available

# Metabolic_Enzyme_52_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_52_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_52_Subcellular_Location:
Membrane; peripheral membrane protein (Potential)

# Metabolic_Enzyme_52_Gene_Sequence:
>3426 bp
ATGGCAGTGCCCGGCGACGCTGCACGAGTCAGGGACAAGCCCGTCCACAGTGGGGTGAGT
CAAGCCCCCACGGCGGGCCGGGACTGCCACCATCGTGCGGACCCCGCATCGCCGCGGGAC
TCGGGCTGCCGTGGCTGCTGGGGAGACCTGGTGCTGCAGCCGCTCCGGAGCTCTCGGAAA
CTTTCCTCCGCGCTGTGCGCGGGCTCCCTATCCTTTCTGCTGGCGCTGCTGGTGAGGCTG
GTCCGCGGGGAGGTCGGCTGTGACCTGGAGCAGTGTAAGGAGGCGGCGGCGGCGGAGGAG
GAGGAAGCAGCCCCGGGAGCAGAAGGGGGCGTCTTCCCGGGGCCTCGGGGAGGTGCTCCC
GGGGGCGGTGCGCGGCTCAGCCCCTGGCTGCAGCCCTCGGCGCTGCTCTTCAGTCTCCTG
TGTGCCTTCTTCTGGATGGGCTTGTACCTCCTGCGCGCCGGGGTGCGCCTGCCTCTGGCT
GTCGCGCTGCTGGCCGCCTGCTGCGGGGGGGAAGCGCTCGTCCAGATTGGGCTGGGCGTC
GGGGAGGATCACTTACTCTCACTCCCCGCTGCGGGGGTGGTGCTCAGCTGCTTGGCCGCC
GCGACATGGCTGGTGCTGAGGCTGAGGCTGGGCGTCCTCATGATCGCCTTGACTAGCGCG
GTCAGGACCGTGTCCCTCATTTCCTTAGAGAGGTTCAAGGTCGCCTGGAGACCTTACCTG
GCGTACCTGGCCGGCGTGCTGGGGATCCTCTTGGCCAGGTACGTGGAACAAATCTTGCCG
CAGTCCGCGGAGGCGGCTCCAAGGGAGCATTTGGGGTCCCAGCTGATTGCTGGGACCAAG
GAAGATATCCCGGTGTTTAAGAGGAGGAGGCGGTCCAGCTCCGTCGTGTCCGCCGAGATG
TCCGGCTGCAGCAGCAAGTCCCATCGGAGGACCTCCCTGCCCTGTATACCGAGGGAACAG
CTCATGGGGCATTCAGAATGGGACCACAAACGAGGGCCAAGAGGATCACAGTCTTCAGGA
ACCAGTATTACTGTGGACATCGCCGTCATGGGCGAAGCCCACGGCCTCATTACCGACCTC
CTGGCAGACCCTTCTCTTCCACCAAACGTGTGCACATCCTTGAGAGCCGTGAGCAACTTG
CTCAGCACACAGCTCACCTTCCAGGCCATTCACAAGCCCAGAGTGAATCCCGTTACTTCG
CTCAGTGAAAACTATACCTGTTCTGACTCTGAAGAGAGCTCTGAAAAAGACAAGCTTGCT
ATTCCAAAGCGCCTGAGAAGGAGTTTGCCTCCTGGCTTGTTGAGACGAGTTTCTTCCACT
TGGACCACCACCACCTCGGCCACAGGTCTACCCACCTTGGAGCCTGCACCAGTACGGAGA
GACCGCAGCACCAGCATCAAACTGCAGGAAGCACCTTCATCCAGTCCTGATTCTTGGAAT
AATCCAGTGATGATGACCCTCACCAAAAGCAGATCCTTTACTTCATCCTATGCTATTTCT
GCAGCTAACCATGTAAAGGCTAAAAAGCAAAGTCGACCAGGTGCCCTCGCTAAAATTTCA
CCTCTTTCATCGCCCTGCTCCTCACCTCTCCAAGGGACTCCTGCCAGCAGCCTGGTCAGC
AAAATTTCTGCAGTGCAGTTTCCAGAATCTGCTGACACAACTGCCAAACAAAGCCTAGGT
TCTCACAGGGCCTTAACTTACACTCAGAGTGCCCCAGACCTATCCCCTCAAATCCTGACT
CCACCTGTTATATGTAGCAGCTGTGGCAGACCATATTCCCAAGGGAATCCTGCTGATGAG
CCCCTGGAGAGAAGTGGGGTAGCCACTCGGACACCAAGTCGAACAGATGACACTGCTCAA
GTTACCTCTGATTATGAAACCAATAACAACAGTGACAGCAGTGACATTGTACAGAATGAA
GATGAAACAGAGTGCCTGAGAGAGCCTCTGAGGAAAGCATCGGCTTGCAGCACCTATGCT
CCTGAGACCATGATGTTTCTGGACAAACCAATTCTTGCTCCCGAACCTCTTGTCATGGAT
AACCTGGACTCAATTATGGAGCAGCTAAATACTTGGAATTTTCCAATTTTTGATTTAGTG
GAAAATATAGGAAGAAAATGTGGCCGTATTCTTAGTCAGGTATCTTACAGACTTTTTGAA
GACATGGGCCTCTTTGAAGCTTTTAAAATTCCAATTAGGGAATTTATGAATTATTTTCAT
GCTTTGGAGATTGGATATAGGGATATTCCTTATCATAACAGAATCCATGCCACTGATGTT
TTACATGCTGTTTGGTATCTTACTACACAGCCTATTCCAGGCCTCTCAACTGTGATTAAT
GATCATGGTTCAACCAGTGATTCAGATTCTGACAGTGGATTTACACATGGACATATGGGA
TATGTATTCTCAAAAACGTATAATGTGACAGATGATAAATACGGATGTCTGTCTGGGAAT
ATCCCTGCCTTGGAGTTGATGGCGCTGTATGTGGCTGCAGCCATGCACGATTATGATCAT
CCAGGAAGGACTAATGCTTTCCTGGTTGCAACTAGTGCTCCTCAGGCGGTGCTATATAAC
GATCGTTCAGTTTTGGAGAATCATCACGCAGCTGCTGCATGGAATCTTTTCATGTCCCGG
CCAGAGTATAACTTCTTAATTAACCTTGACCATGTGGAATTTAAGCATTTCCGTTTCCTT
GTCATTGAAGCAATTTTGGCCACTGACCTGAAGAAACACTTTGACTTCGTAGCCAAATTT
AATGGCAAGGTAAATGATGATGTTGGAATAGATTGGACCAATGAAAATGATCGTCTACTG
GTTTGTCAAATGTGTATAAAGTTGGCTGATATCAATGGTCCAGCTAAATGTAAAGAACTC
CATCTTCAGTGGACAGATGGTATTGTCAATGAATTTTATGAACAGGGTGATGAAGAGGCC
AGCCTTGGATTACCCATAAGCCCCTTCATGGATCGTTCTGCTCCTCAGCTGGCCAACCTT
CAGGAATCCTTCATCTCTCACATTGTGGGGCCTCTGTGCAACTCCTATGATTCAGCAGGA
CTAATGCCTGGAAAATGGGTGGAAGACAGCGATGAGTCAGGAGATACTGATGACCCAGAA
GAAGAGGAGGAAGAAGCACCAGCACCAAATGAAGAGGAAACCTGTGAAAATAATGAATCT
CCAAAAAAGAAGACTTTCAAAAGGAGAAAAATCTACTGCCAAATAACTCAGCACCTCTTA
CAGAACCACAAGATGTGGAAGAAAGTCATTGAAGAGGAGCAACGGTTGGCAGGCATAGAA
AATCAATCCCTGGACCAGACCCCTCAGTCGCACTCTTCAGAACAGATCCAGGCTATCAAG
GAAGAAGAAGAAGAGAAAGGGAAACCAAGAGGCGAGGAGATACCAACCCAAAAGCCAGAC
CAGTGA

# Metabolic_Enzyme_52_GenBank_ID_Gene:
M91667

# Metabolic_Enzyme_52_Chromosome_Location:
Not Available

# Metabolic_Enzyme_52_Locus:
Not Available

# Metabolic_Enzyme_52_SNPs:
Not Available

# Metabolic_Enzyme_52_General_References:
1315035; 8695850

# Metabolic_Enzyme_52_References:
Not Available

# Metabolic_Enzyme_53_ID:
5873

# Metabolic_Enzyme_53_Name:
Ubiquitin-conjugating enzyme E2 L3

# Metabolic_Enzyme_53_Synonyms:
Ubiquitin-protein ligase L3; Ubiquitin carrier protein L3; UbcH7; E2-F1; L-UBC

# Metabolic_Enzyme_53_Gene_Name:
UBE2L3

# Metabolic_Enzyme_53_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 L3
MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAE
YPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHP
LRADLAEEYSKDRKKFCKNAEEFTKKYGEKRPVD

# Metabolic_Enzyme_53_Number_of_Residues:
154

# Metabolic_Enzyme_53_Molecular_Weight:
17862

# Metabolic_Enzyme_53_Theoretical_pI:
8.79

# Metabolic_Enzyme_53_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_53_General_Function:
Not Available

# Metabolic_Enzyme_53_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53

# Metabolic_Enzyme_53_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_53_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_53_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_53_Signals:
None

# Metabolic_Enzyme_53_Transmembrane_Regions:
None

# Metabolic_Enzyme_53_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_53_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_53_GenBank_ID_Protein:
1488377

# Metabolic_Enzyme_53_SwissProt_ID:
UB2L3_HUMAN (P68036)

# Metabolic_Enzyme_53_swissprot_Name:
Not Available

# Metabolic_Enzyme_53_Genecard_id:
UBE2L3

# Metabolic_Enzyme_53_Geneatlas_id:
UBE2L3

# Metabolic_Enzyme_53_hgnc_id:
HGNC:12488

# Metabolic_Enzyme_53_PDB_ID:
1FBV

# Metabolic_Enzyme_53_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_53_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_53_Subcellular_Location:
Not Available

# Metabolic_Enzyme_53_Gene_Sequence:
>465 bp
ATGGCGGCCAGCAGGAGGCTGATGAAGGAGCTTGAAGAAATCCGCAAATGTGGGATGAAA
AACTTCCGTAACATCCAGGTTGATGAAGCTAATTTATTGACTTGGCAAGGGCTTATTGTT
CCTGACAACCCTCCATATGATAAGGGAGCCTTCAGAATCGAAATCAACTTTCCAGCAGAG
TACCCATTCAAACCACCGAAGATCACATTTAAAACAAAGATCTATCACCCAAACATCGAC
GAAAAGGGGCAGGTCTGTCTGCCAGTAATTAGTGCCGAAAACTGGAAGCCAGCAACCAAA
ACCGACCAAGTAATCCAGTCCCTCATAGCACTGGTGAATGACCCCCAGCCTGAGCACCCG
CTTCGGGCTGACCTAGCTGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGAATGCT
GAAGAGTTTACAAAGAAATATGGGGAAAAGCGACCTGTGGACTAA

# Metabolic_Enzyme_53_GenBank_ID_Gene:
S81003

# Metabolic_Enzyme_53_Chromosome_Location:
Not Available

# Metabolic_Enzyme_53_Locus:
Not Available

# Metabolic_Enzyme_53_SNPs:
Not Available

# Metabolic_Enzyme_53_General_References:
8563171; 8576257; 9693040; 8144544; 10760570; 10558980; 10966114; 12612082

# Metabolic_Enzyme_53_References:
Not Available

# Metabolic_Enzyme_54_ID:
5874

# Metabolic_Enzyme_54_Name:
RNA 3'-terminal phosphate cyclase

# Metabolic_Enzyme_54_Synonyms:
RNA-3'-phosphate cyclase; RNA cyclase

# Metabolic_Enzyme_54_Gene_Name:
RTCD1

# Metabolic_Enzyme_54_Protein_Sequence:
>RNA 3'terminal phosphate cyclase
MAGPRVEVDGSIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIR
DLCDGQLEGAEIGSTEITFTPEKIKGGIHTADTKTAGSVCLLMQVSMPCVLFAASPSELH
LKGGTNAEMAPQIDYTVMVFKPIVEKFGFIFNCDIKTRGYYPKGGGEVIVRMSPVKQLNP
INLTERGCVTKIYGRAFVAGVLPFKVAKDMAAAAVRCIRKEIRDLYVNIQPVQEPKDQAF
GNGNGIIIIAETSTGCLFAGSSLGKRGVNADKVGIEAAEMLLANLRHGGTVDEYLQDQLI
VFMALANGVSRIKTGPVTLHTQTAIHFAEQIAKAKFIVKKSEDEEDAAKDTYIIECQGIG
MTNPNL

# Metabolic_Enzyme_54_Number_of_Residues:
366

# Metabolic_Enzyme_54_Molecular_Weight:
39337

# Metabolic_Enzyme_54_Theoretical_pI:
7.94

# Metabolic_Enzyme_54_GO_Classification:
>>>
Function:  catalytic activity
Function:  cyclase activity
Function:  RNA-3'-phosphate cyclase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_54_General_Function:
RNA processing and modification 

# Metabolic_Enzyme_54_Specific_Function:
Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps:(A) adenylation of the enzyme by ATP; (B) the enzyme acts on RNA-N3'P to produce RNA-N3'PP5'A; (C) a non catalytic nucleophilic attack by the adjacent 2'hydroxyl on the phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing

# Metabolic_Enzyme_54_Pathway:
Not Available

# Metabolic_Enzyme_54_Reaction:
ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate

# Metabolic_Enzyme_54_Pfam_Domain_Function:
PF01137:RTC;
PF05189:RTC_insert

# Metabolic_Enzyme_54_Signals:
None

# Metabolic_Enzyme_54_Transmembrane_Regions:
None

# Metabolic_Enzyme_54_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_54_EC_Link:
EC 6.5.1.4

# Metabolic_Enzyme_54_GenBank_ID_Protein:
2125812

# Metabolic_Enzyme_54_SwissProt_ID:
RTC1_HUMAN (O00442)

# Metabolic_Enzyme_54_swissprot_Name:
Not Available

# Metabolic_Enzyme_54_Genecard_id:
RTCD1

# Metabolic_Enzyme_54_Geneatlas_id:
RTCD1

# Metabolic_Enzyme_54_hgnc_id:
HGNC:17981

# Metabolic_Enzyme_54_PDB_ID:
Not Available

# Metabolic_Enzyme_54_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_54_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_54_Subcellular_Location:
Nucleus; nucleoplasm

# Metabolic_Enzyme_54_Gene_Sequence:
>1101 bp
ATGGCGGGGCCGCGGGTGGAGGTCGATGGCAGCATCATGGAAGGGGGCGGCCAGATCCTG
AGAGTCTCTACGGCCTTGAGCTGTCTCCTAGGCCTCCCCTTGCGGGTGCAGAAGATCCGA
GCCGGCCGGAGCACGCCAGGCCTGAGGCCTCAACATTTATCTGGACTGGAAATGATTCGA
GATTTGTGTGATGGGCAACTGGAGGGGGCAGAAATTGGCTCAACAGAAATAACCTTTACA
CCAGAGAAGATCAAAGGTGGAATCCACACAGCAGATACCAAGACAGCAGGGAGTGTGTGC
CTCTTGATGCAGGTCTCAATGCCGTGTGTTCTCTTTGCTGCTTCTCCATCAGAACTTCAT
TTGAAAGGTGGAACTAATGCTGAAATGGCACCACAGATCGATTATACAGTGATGGTCTTC
AAGCCAATTGTTGAAAAATTTGGTTTCATATTTAATTGTGACATTAAAACAAGGGGATAT
TACCCAAAAGGGGGTGGTGAAGTGATTGTTCGAATGTCACCAGTTAAACAATTGAACCCT
ATAAATTTAACTGAGCGTGGCTGTGTGACTAAGATATATGGAAGAGCTTTCGTTGCTGGT
GTTTTGCCATTTAAAGTAGCAAAAGATATGGCAGCGGCAGCAGTTAGATGCATCAGAAAG
GAGATCCGGGATTTGTATGTTAACATCCAGCCTGTTCAAGAACCTAAAGACCAAGCATTT
GGCAATGGAAATGGAATAATAATTATTGCTGAGACCTCCACTGGCTGTTTGTTTGCTGGA
TCATCGCTTGGTAAACGAGGTGTAAATGCAGACAAAGTTGGAATTGAAGCTGCCGAAATG
CTATTAGCAAATCTTAGACATGGTGGTACTGTGGATGAGTATCTGCAAGACCAGCTGATT
GTTTTCATGGCATTAGCCAATGGAGTTTCCAGAATAAAAACAGGACCAGTTACACTCCAT
ACGCAAACCGCGATACATTTTGCTGAACAAATAGCAAAGGCTAAATTTATTGTGAAGAAA
TCAGAAGATGAAGAAGACGCCGCTAAAGATACTTATATTATTGAATGCCAAGGAATTGGG
ATGACAAATCCAAATCTATAG

# Metabolic_Enzyme_54_GenBank_ID_Gene:
Y11651

# Metabolic_Enzyme_54_Chromosome_Location:
Not Available

# Metabolic_Enzyme_54_Locus:
Not Available

# Metabolic_Enzyme_54_SNPs:
Not Available

# Metabolic_Enzyme_54_General_References:
9184239; 2199762

# Metabolic_Enzyme_54_References:
Not Available

# Metabolic_Enzyme_55_ID:
5875

# Metabolic_Enzyme_55_Name:
Putative adenylate kinase 7

# Metabolic_Enzyme_55_Synonyms:
Not Available

# Metabolic_Enzyme_55_Gene_Name:
AK7

# Metabolic_Enzyme_55_Protein_Sequence:
>Putative adenylate kinase 7
MAEEEETAALTEKVIRTQRVFINLLDSYSSGNIGKFLSNCVVGASLEEITEEEEEEDENK
SAMLEASSTKVKEGTFQIVGTLSKPDSPRPDFAVETYSAISREDLLMRLLECDVIIYNIT
ESSQQMEEAIWAVSALSEEVSHFEKRKLFILLSTVMTWARSKALDPEDSEVPFTEEDYRR
RKSHPNFLDHINAEKMVLKFGKKARKFAAYVVAAGLQYGAEGGMLHTFFKMAWLGEIPAL
PVFGDGTNVIPTIHVLDLAGVIQNVIDHVPKPHYLVAVDESVHTLEDIVKCISKNTGPGK
IQKIPRENAYLTKDLTQDCLDHLLVNLRMEALFVKENFNIRWAAQTGFVENINTILKEYK
QSRGLMPIKICILGPPAVGKSSIAKELAKYYKLHHIQLKDVISEAIAKLEAIVAPNDVGE
GEEEVEEEEEEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEKLKSMPCRNQGYIL
DGFPKTYDQAKDLFNQEDEEEEDDVRGRMFPFDKLIIPEFVCALDASDEFLKERVINLPE
SIVAGTHYSQDRFLRALSNYRDINIDDETVFNYFDELEIHPIHIDVGKLEDAQNRLAIKQ
LIKEIGEPRNYGLTDEEKAEEERKAAEERLAREAAEEAEREHQEAVEMAEKIARWEEWNK
RLEEVKREERELLEAQSIPLRNYLMTYVMPTLIQGLNECCNVRPEDPVDFLAEYLFKNNP
EAQ

# Metabolic_Enzyme_55_Number_of_Residues:
723

# Metabolic_Enzyme_55_Molecular_Weight:
82673

# Metabolic_Enzyme_55_Theoretical_pI:
4.40

# Metabolic_Enzyme_55_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleotide kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_55_General_Function:
Not Available

# Metabolic_Enzyme_55_Specific_Function:
ATP + AMP = 2 ADP

# Metabolic_Enzyme_55_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_55_Reaction:
ATP + AMP = 2 ADP

# Metabolic_Enzyme_55_Pfam_Domain_Function:
PF05186:Dpy-30

# Metabolic_Enzyme_55_Signals:
None

# Metabolic_Enzyme_55_Transmembrane_Regions:
None

# Metabolic_Enzyme_55_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_55_EC_Link:
EC 2.7.4.3

# Metabolic_Enzyme_55_GenBank_ID_Protein:
16553126

# Metabolic_Enzyme_55_SwissProt_ID:
KAD7_HUMAN (Q96M32)

# Metabolic_Enzyme_55_swissprot_Name:
Not Available

# Metabolic_Enzyme_55_Genecard_id:
AK7

# Metabolic_Enzyme_55_Geneatlas_id:
AK7

# Metabolic_Enzyme_55_hgnc_id:
HGNC:20091

# Metabolic_Enzyme_55_PDB_ID:
Not Available

# Metabolic_Enzyme_55_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_55_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_55_Subcellular_Location:
Not Available

# Metabolic_Enzyme_55_Gene_Sequence:
>2172 bp
ATGGCTGAAGAAGAGGAAACTGCTGCTCTCACGGAGAAGGTTATCCGGACCCAGAGGGTG
TTTATAAACCTGTTGGATTCCTACAGCAGCGGAAACATCGGGAAGTTTCTATCTAACTGT
GTAGTTGGGGCTTCGCTTGAAGAAATTACAGAGGAAGAGGAAGAGGAAGATGAAAATAAG
TCAGCTATGCTGGAAGCTTCCTCAACCAAAGTGAAGGAAGGCACATTCCAGATTGTGGGC
ACGCTGTCCAAGCCTGACAGCCCGCGGCCTGACTTTGCGGTGGAGACGTACTCTGCCATC
TCTCAAGAAGACCTTCTCATGCGCCTGCTGGAGTGTGATGTTATTATTTATAACATCACT
GAGAGCTCACAGCAAATGGAGGAAGCCATCTGGGCAGTCTCTGCACTCAGTGAAGAAGTC
AGCCACTTTGAAAAGCGAAAGCTATTTATTTTACTGTCGACGGTGATGACTTGGGCGCGC
TCCAAAGCCCTGGACCCCGAGGATTCTGAGGTTCCATTCACTGAAGAAGATTATCGAAGA
AGAAAGTCTCATCCTAATTTTCTGGACCACATAAATGCTGAAAAAATGGTTCTCAAATTT
GGAAAAAAGGCCAGAAAATTTGCAGCATACGTAGTTGCTGCTGGACTCCAGTATGGAGCG
GAAGGAGGCATGTTACACACATTTTTTAAGATGGCTTGGTTGGGCGAGATTCCTGCATTA
CCAGTTTTTGGCGATGGAACAAATGTAATTCCAACAATCCATGTTCTTGATCTAGCAGGA
GTGATACAAAACGTCATAGATCACGTGCCAAAGCTTCACTACCTGGTTGCTGTGGATGAG
TCTGTTCATACCCTGGAAGACATAGTCAAGTGTATCAGTAAAAATACTGGCCCTGGGAAA
ATCCAGAAAATACCCAGAGAAAATGCATACCTAACCAAGGACTTAACGCAAGATTGTCTT
GACCATTTACTGGTCAACTTAAGAATGGAAGCGCTCTTTGTGAAGGAGAATTTTAATATT
CGATGGGCTGCCCAAACAGGATTTGTGGAAAATATCAACACTATCCTCAAGGAGTACAAG
CAAAGCAGAGGATTGATGCCAATCAAGATCTGCATTCTTGGTCCCCCTGCTGTGGGAAAA
TCCAGTATTGCTAAAGAATTGGCCAAGTACTACAAACTGCATCACATCCAACTGAAGGAT
GTCATTTCTGAAGCCATAGCAAAACTGGGGGCGATTGTTGCCCCTAACGATGTAGGGGAA
GGAGAAGAAGAAGTCGAAGAGGAAGAGGAGGAGGAGAATGTGGAAGATGCACAGGAGCTC
CTAGATGGCATCAAGGAGAGCATGGAGCAGAATGCAGGTCAACTAGACGATCAATATATA
ATTAGATTTATGAAAGAAAAGCTAAAATCAATGCCTTGCAGGAATCAAGGTTATATTTTG
GATGGATTCCCAAAGACCTATGATCAAGCAAAAGACCTGTTCAATCAGGAAGATGAGGAG
GAGGAAGATGATGTCAGAGGCAGAATGTTTCCCTTTGATAAATTAATTATACCTGAATTC
GTTTGTGCACTGGATGCTTCGGATGAGTTTCTGAAGGAGCGTGTGATAAACCTTCCTGAG
AGCATCGTGGCGGGGACCCACTACAGCCAAGACCGATTCCTCCGGGCTCTGAGCAACTAC
CGGGACATCAATATCGACGATGAGACTGTCTTCAACTATTTTGATGAACTTGAAATTCAC
CCGATACATATTGATGTAGGAAAACTTGAAGATGCTCAGAATAGACTTGCTATCAAACAG
CTCATCAAAGAGATTGGGGAGCCTCGAAATTATGGTTTAACAGACGAAGAAAAGGCAGAA
GAGGAGCGGAAGGCTGCGGAGGAGCGGCTGGCCAGGGAGGCTGCTGAGGAAGCAGAACGC
GAGCACCAGGAGGCCGTGGAGATGGCAGAGAAGATAGCTCGCTGGGAGGAGTGGAATAAA
CGACTGGAGGAAGTGAAAAGAGAAGAAAGAGAATTACTGGAGGCTCAGTCAATTCCCCTG
AGAAACTATTTAATGACCTATGTGATGCCAACTCTTATTCAGGGCCTGAATGAATGTTGC
AACGTCCGACCCGAAGACCCTGTTGATTTTCTGGCAGAATATCTCTTCAAGAACAATCCT
GAAGCACAGTGA

# Metabolic_Enzyme_55_GenBank_ID_Gene:
AK057426

# Metabolic_Enzyme_55_Chromosome_Location:
Not Available

# Metabolic_Enzyme_55_Locus:
Not Available

# Metabolic_Enzyme_55_SNPs:
Not Available

# Metabolic_Enzyme_55_General_References:
12508121

# Metabolic_Enzyme_55_References:
Not Available

# Metabolic_Enzyme_56_ID:
5876

# Metabolic_Enzyme_56_Name:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

# Metabolic_Enzyme_56_Synonyms:
Not Available

# Metabolic_Enzyme_56_Gene_Name:
PDE10A

# Metabolic_Enzyme_56_Protein_Sequence:
>cAMP and cAMPinhibited cGMP 3',5'cyclic phosphodiesterase 10
AMRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESA
PKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGE
CNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGL
ESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQV
CRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKEL
YSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLY
TGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYH
RIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGI
FVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFT
DLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHN
IFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLM
MTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGF
YNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED


# Metabolic_Enzyme_56_Number_of_Residues:
779

# Metabolic_Enzyme_56_Molecular_Weight:
88413

# Metabolic_Enzyme_56_Theoretical_pI:
6.57

# Metabolic_Enzyme_56_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_56_General_Function:
Not Available

# Metabolic_Enzyme_56_Specific_Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This enzyme can hydrolyze both cAMP and cGMP, having a higher affinity for cAMP

# Metabolic_Enzyme_56_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_56_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_56_Pfam_Domain_Function:
PF01590:GAF;
PF00233:PDEase_I

# Metabolic_Enzyme_56_Signals:
None

# Metabolic_Enzyme_56_Transmembrane_Regions:
None

# Metabolic_Enzyme_56_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_56_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_56_GenBank_ID_Protein:
4958858

# Metabolic_Enzyme_56_SwissProt_ID:
PDE10_HUMAN (Q9Y233)

# Metabolic_Enzyme_56_swissprot_Name:
Not Available

# Metabolic_Enzyme_56_Genecard_id:
PDE10A

# Metabolic_Enzyme_56_Geneatlas_id:
PDE10A

# Metabolic_Enzyme_56_hgnc_id:
HGNC:8772

# Metabolic_Enzyme_56_PDB_ID:
Not Available

# Metabolic_Enzyme_56_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_56_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_56_Subcellular_Location:
Note=Located mostly to soluble cellular fractions

# Metabolic_Enzyme_56_Gene_Sequence:
>2340 bp
ATGAGGATAGAAGAGAGGAAATCCCAACATTTAACAGGTTTGACAGATGAAAAAGTGAAG
GCATATCTTTCTCTTCACCCCCAGGTATTAGATGAATTTGTATCTGAAAGTGTTAGTGCA
GAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGATGAATCAGCTCCT
AAGGAAGTCAGCAGGTACCAAGATACGAATATGCAGGGAGTTGTATATGAACTAAACAGC
TATATAGAACAACGGTTGGACACAGGAGGAGACAACCAGCTACTCCTCTATGAACTGAGC
AGCATCATTAAAATAGCCACAAAAGCCGATGGATTTGCACTGTATTTCCTTGGAGAGTGC
AATAATAGCCTGTGTATATTCACGCCACCTGGGATAAAGGAAGGAAAACCCCGCCTCATC
CCTGCTGGGCCCATCACTCAGGGCACCACCGTCTCTGCTTATGTGGCCAAGTCCAGGAAA
ACACTGCTAGTAGAAGACATCCTTGGAGATGAACGATTTCCAAGAGGTACTGGACTGGAA
TCAGGGACTCGTATCCAGTCTGTTCTTTGCTTACCAATTGTCACTGCAATTGGTGACTTG
ATTGGTATTCTCGAGCTGTATCGGCACTGGGGCAAAGAAGCCTTCTGTCTTAGTCACCAG
GAGGTTGCAACAGCAAATCTTGCCTGGGCTTCAGTAGCAATACATCAGGTGCAGGTATGC
AGAGGCCTTGCCAAACAGACAGAATTGAATGACTTCCTACTCGACGTATCAAAAACATAT
TTTGATAACATAGTTGCAATAGATTCTCTACTTGAACACATAATGATATATGCAAAAAAC
CTGGTGAATGCCGATCGTTGTGCGCTTTTCCAGGTGGACCATAAGAACAAGGAGTTATAT
TCAGACCTTTTTGATATTGGAGAGGAAAAGGAAGGAAAACCTGTCTTCAAGAAGACCAAA
GAGATAAGATTTTCAATTGAGAAAGGAATTGCTGGCCAAGTAGCAAGAACAGGGGAAGTC
CTGAACATTCCAGATGCCTATGCAGACCCACGCTTTAACAGAGAAGTAGACTTGTACACA
GGCTACACCACGCGGAACATCCTGTGCATGCCCATCGTCAGCCGAGGCAGCGTGATAGGT
GTGGTGCAGATGGTCAACAAAATCAGTGGCAGTGCCTTCTCTAAAACAGATGAAAACAAC
TTCAAAATGTTTGCCGTCTTTTGTGCTTTAGCCTTACACTGTGCTAATATGTATCATAGA
ATTCGCCACTCAGAGTGCATTTACCGGGTAACGATGGAAAAGCTGTCCTACCATAGCATT
TGTACTTCAGAAGAGTGGCAAGGTCTCATGCAATTCACCCTTCCCGTGCGTCTCTGCAAA
GAAATTGAATTATTCCACTTTGACATTGGTCCTTTTGAAAACATGTGGCCTGGAATTTTT
GTCTACATGGTTCATCGGTCCTGTGGGACATCCTGCTTTGAGCTTGAAAAGTTGTGTCGT
TTTATTATGTCTGTGAAGAAGAACTATCGGCGGGTTCCTTATCACAACTGGAAGCATGCG
GTCACTGTAGCACACTGCATGTATGCCATACTTCAGAACAATCACACGCTTTTCACAGAC
CTTGAGCGCAAAGGACTGCTGATTGCGTGTCTGTGTCATGACCTGGACCACAGGGGCTTC
AGTAACAGCTACCTGCAGAAGTTCGACCACCCTCTGGCCGCTCTCTACTCCACTTCCACC
ATGGAGCAGCACCACTTCTCCCAGACTGTGTCCATCCTTCAGTTGGAAGGGCACAATATC
TTCTCCACTCTGAGCTCCAGTGAATATGAGCAGGTGCTTGAGATCATCCGCAAAGCCATC
ATTGCCACAGACCTTGCTTTATACTTTGGAAACAGGAAGCAGTTGGAAGAGATGTACCAG
ACCGGATCACTAAACCTTAATAATCAATCACATAGAGACCGTGTAATTGGTTTGATGATG
ACTGCCTGTGACCTTTGTTCTGTGACAAAACTGTGGCCCGTTACAAAATTGACGGCAAAT
GATATATATGCAGAATTCTGGGCTGAGGGTGATGAAATGAAGAAATTGGGAATACAGCCT
ATTCCTATGATGGACAGAGACAAGAAGGATGAAGTCCCCCAAGGCCAGCTTGGGTTCTAC
AATGCCGTGGCCATTCCCTGCTATACAACCCTTACCCAGATCCTCCCTCCCACGGAGCCT
CTTCTGAAAGCATGCAGGGATAATCTCAGTCAGTGGGAGAAGGTGATTCGAGGGGAGGAG
ACTGCAACCTGGATTTCATCCCCATCCGTGGCTCAGAAGGCAGCTGCATCTGAAGATTGA


# Metabolic_Enzyme_56_GenBank_ID_Gene:
AB020593

# Metabolic_Enzyme_56_Chromosome_Location:
Not Available

# Metabolic_Enzyme_56_Locus:
Not Available

# Metabolic_Enzyme_56_SNPs:
Not Available

# Metabolic_Enzyme_56_General_References:
10373451; 10393245; 14574404

# Metabolic_Enzyme_56_References:
Not Available

# Metabolic_Enzyme_57_ID:
5877

# Metabolic_Enzyme_57_Name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

# Metabolic_Enzyme_57_Synonyms:
Cam-PDE 1C; hCam-3

# Metabolic_Enzyme_57_Gene_Name:
PDE1C

# Metabolic_Enzyme_57_Protein_Sequence:
>Calcium/calmodulindependent 3',5'cyclic nucleotide phosphodiesterase 1
CMESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVV
DLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLR
RSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEA
SGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQT
VHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLEN
HHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQP
EAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRK
STMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAK
RSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKA
RLAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSG
EQQQNGDFKDGKNKTDKKDHSNIGNDSKKTDGTKQRSHGSPAPSTSSTCRLTLPVIKPPL
RHFKRPAYASSSYAPSVSKKTDEHPARYKMLDQRIKMKKIQNISHNWNRK

# Metabolic_Enzyme_57_Number_of_Residues:
709

# Metabolic_Enzyme_57_Molecular_Weight:
80761

# Metabolic_Enzyme_57_Theoretical_pI:
9.31

# Metabolic_Enzyme_57_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_57_General_Function:
Not Available

# Metabolic_Enzyme_57_Specific_Function:
Has a high affinity for both cAMP and cGMP

# Metabolic_Enzyme_57_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_57_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_57_Pfam_Domain_Function:
PF00233:PDEase_I;
PF08499:PDEase_I_N

# Metabolic_Enzyme_57_Signals:
None

# Metabolic_Enzyme_57_Transmembrane_Regions:
None

# Metabolic_Enzyme_57_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_57_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_57_GenBank_ID_Protein:
1151111

# Metabolic_Enzyme_57_SwissProt_ID:
PDE1C_HUMAN (Q14123)

# Metabolic_Enzyme_57_swissprot_Name:
Not Available

# Metabolic_Enzyme_57_Genecard_id:
PDE1C

# Metabolic_Enzyme_57_Geneatlas_id:
PDE1C

# Metabolic_Enzyme_57_hgnc_id:
HGNC:8776

# Metabolic_Enzyme_57_PDB_ID:
Not Available

# Metabolic_Enzyme_57_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_57_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_57_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_57_Gene_Sequence:
>1905 bp
ATGGAGTCGCCAACCAAGGAGATTGAAGAATTTGAGAGCAACTCTCTGAAATACCTGCAA
CCGGAACAGATCGAGAAAATCTGGCTTCGGCTCCGCGGGCTGAGGAAATATAAGAAAACG
TCCCAGAGATTACGGTCTTTGGTCAAACAATTAGAGAGAGGGGAAGCTTCAGTGGTAGAT
CTTAAGAAGAATTTGGAATATGCAGCCACAGTGCTTGAATCTGTGTATATTGATGAAACA
AGGAGACTCCTGGATACAGAGGATGAGCTCAGTGACATTCAGTCAGATGCTGTGCCTTCT
GAGGTCCGAGACTGGCTGGCCTCCACCTTCACGCGGCAGATGGGGATGATGCTCAGGAGG
AGCGACGAGAAGCCCCGGTTCAAGAGCATCGTTCACGCAGTGCAGGCTGGGATATTTGTG
GAGAGAATGTATAGACGGACATCAAACATGGTTGGACTGAGCTATCCACCAGCTGTTATT
GAGGCATTAAAGGATGTGGACAAGTGGTCCTTTGACGTCTTTTCCCTCAATGAGGCCAGT
GGGGATCATGCACTGAAATTTATTTTCTATGAACTACTCACACGTTATGATCTGATCAGC
CGTTTCAAGATCCCCATTTCTGCACTTGTCTCATTTGTGGAGGCCCTGGAAGTGGGATAC
AGCAAGCACAAAAATCCTTACCATAACTTAATGCACGCTGCCGATGTTACACAGACAGTG
CATTACCTCCTCTATAAGACAGGAGTGGCGAACTGGCTGACGGAGCTGGAGATCTTTGCT
ATAATCTTCTCAGCTGCCATCCATGACTACGAGCATACCGGAACCACCAACAATTTCCAC
ATTCAGACTCGGTCTGATCCAGCTATTCTGTATAATGACAGATCTGTACTGGAGAATCAC
CATTTAAGTGCAGCTTATCGCCTTCTGCAAGATGACGAGGAAATGAATATTTTGATTAAC
CTCTCAAAGGATGACTGGAGGGAGTTTCGAACCTTGGTAATTGAAATGGTGATGGCCACA
GATATGTCTTGTCACTTCCAACAAATCAAAGCAATGAAGACTGCTCTGCAGCAGCCAGAA
GCCATTGAAAAGCCAAAAGCCTTATCCCTTATGCTGCATACAGCAGATATTAGCCATCCA
GCAAAAGCATGGGACCTCCATCATCGCTGGACAATGTCACTCCTGGAGGAGTTCTTCAGA
CAGGGTGACAGAGAAGCAGAGCTGGGGCTGCCTTTTTCTCCTCTGTGTGACCGAAAGTCC
ACTATGGTTGCTCAGTCACAAGTAGGTTTCATTGATTTCATCGTGGAACCCACCTTCACT
GTGCTTACGGACATGACCGAGAAGATTGTGAGTCCATTAATCGATGAAACCTCTCAAACT
GGTGGGACAGGACAGAGGCGTTCGAGTTTGAATAGCATCAGCTCGTCAGATGCCAAGCGA
TCAGGTGTCAAGACCTCTGGTTCAGAGGGAAGTGCCCCGATCAACAATTCTGTCATCTCC
GTTGACTATAAGAGCTTTAAAGCTACTTGGACGGAAGTGGTGCACATCAATCGGGAGAGA
TGGAGGGCCAAGGTACCCAAAGAGGAGAAGGCCAAGAAGGAAGCAGAGGAAAAGGCTCGC
CTGGCCGCAGAGGAGCAGCAAAAGGAAATGGAAGCCAAAAGCCAGGCTGAAGAAGGCGCA
TCTGGCAAAGCTGAGAAAAAGACGTCTGGAGAAACTAAGAATCAAGTCAATGGAACACGG
GCAAACAAAAGTGACAACCCTCGTGGGAAAAATTCCAAAGCCGAGAAGTCATCAGGAGAA
CAGCAACAGAATGGTGACTTCAAAGATGGTAAAAATAAGACAGACAAGAAGGATCACTCT
AACATCGGAAATGATTCAAAGAAAACAGATGATTCACAAGAGTAA

# Metabolic_Enzyme_57_GenBank_ID_Gene:
U40371

# Metabolic_Enzyme_57_Chromosome_Location:
Not Available

# Metabolic_Enzyme_57_Locus:
Not Available

# Metabolic_Enzyme_57_SNPs:
Not Available

# Metabolic_Enzyme_57_General_References:
8557689

# Metabolic_Enzyme_57_References:
Not Available

# Metabolic_Enzyme_58_ID:
5878

# Metabolic_Enzyme_58_Name:
Tyrosyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_58_Synonyms:
Tyrosyl--tRNA ligase; TyrRS

# Metabolic_Enzyme_58_Gene_Name:
YARS

# Metabolic_Enzyme_58_Protein_Sequence:
>TyrosyltRNA synthetase, cytoplasmic
MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIA
DFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKG
TDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVD
AQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKED
VKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFA
AEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEP
EEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLV
VVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEE
LKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS

# Metabolic_Enzyme_58_Number_of_Residues:
528

# Metabolic_Enzyme_58_Molecular_Weight:
59144

# Metabolic_Enzyme_58_Theoretical_pI:
7.05

# Metabolic_Enzyme_58_GO_Classification:
>>>
Function:  tyrosine-tRNA ligase activity
Function:  nucleic acid binding
Function:  RNA binding
Function:  tRNA binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  tyrosyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_58_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_58_Specific_Function:
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)

# Metabolic_Enzyme_58_Pathway:
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_58_Reaction:
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)

# Metabolic_Enzyme_58_Pfam_Domain_Function:
PF00579:tRNA-synt_1b;
PF01588:tRNA_bind

# Metabolic_Enzyme_58_Signals:
None

# Metabolic_Enzyme_58_Transmembrane_Regions:
None

# Metabolic_Enzyme_58_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_58_EC_Link:
EC 6.1.1.1

# Metabolic_Enzyme_58_GenBank_ID_Protein:
1184699

# Metabolic_Enzyme_58_SwissProt_ID:
SYYC_HUMAN (P54577)

# Metabolic_Enzyme_58_swissprot_Name:
Not Available

# Metabolic_Enzyme_58_Genecard_id:
YARS

# Metabolic_Enzyme_58_Geneatlas_id:
YARS

# Metabolic_Enzyme_58_hgnc_id:
HGNC:12840

# Metabolic_Enzyme_58_PDB_ID:
Not Available

# Metabolic_Enzyme_58_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_58_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_58_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_58_Gene_Sequence:
>1167 bp
ATGGGGGACGCTCCCAGCCCTGAAGAGAAACTGCACCTTATCACCCGGAACCTGCAGGAG
GTTCTGGGGGAAGAGAAGCTGAAGGAGATACTGAAGGAGCGGGAACTTAAAATTTACTGG
GGAACGGCAACCACGGGCAAACCACATGTGGCTTACTTTGTGCCCATGTCAAAGATTGCA
GACTTCTTAAAGGCAGGGTGTGAGGTAACAATTCTGTTTGCGGACCTCCACGCATACCTG
GATAACATGAAAGCCCCATGGGAACTTCTAGAACTCCGAGTCAGTTACTATGAGAATGTG
ATCAAAGCAATGCTGGAGAGCATTGGTGTGCCCTTGGAGAAGCTCAAGTTCATCAAAGGC
ACTGATTACCAGCTCAGCAAAGAGTACACACTAGATGTGTACAGACTCTCCTCCGTGGTC
ACACAGCACGATTCCAAGAAGGCTGGAGCTGAGGTGGTAAAGCAGGTGGAGCACCCTTTG
CTGAGTGGCCTCTTATACCCCGGACTGCAGGCTTTGGATGAAGAGTATTTAAAAGTAGAT
GCCCAATTTGGAGGCATTGATCAGAGAAAGATTTTCACCTTTGCAGAGAAGTACCTCCCT
GCACTTGGCTATTCAAAACGGGTCCATCTGATGAATCCTATGGTTCCAGGATTAACAGGC
AGCAAAATGAGCTCTTCAGAAGAGGAGTCCAAGATTGATCTCCTTGATCGGAAGGAGGAT
GTGAAGAAAAAACTGAAGAAGGCCTTCTGTGAGCCAGGAAATGTGGAGAACAATGGGGTT
CTGTCCTTCATCAAGCATGTCCTTTTTCCCCTTAAGTCCGAGTTTGTGATCCTACGAGAT
GAGAAATGGGGTGGAAACAAAACCTACACAGCTTACGTGGACCTGGAAAAGGACTTTGCT
GCTGAGGTTGTACATCCTGGAGACCTGAAGAATTCTGTTGAAGTCGCACTGAACAAGTTG
CTGGATCCAATCCGGGAAAAGTTTAATACCCCTGCCCTGAAAAAACTGGCCAGCGCTGCC
TACCCAGATCCCTCAAAGCAGAAGCCAATGGCCAAAGGCCTGCCAAGAATTCAGAACCAG
AGGAGGTCATCCCATCCCGGCTGGATATCCGTGTGGGGAAAATCATCACTGTGGAGAAGC
ACCCAGATGCAGACAGCCTGTATGTAG

# Metabolic_Enzyme_58_GenBank_ID_Gene:
U40714

# Metabolic_Enzyme_58_Chromosome_Location:
Not Available

# Metabolic_Enzyme_58_Locus:
Not Available

# Metabolic_Enzyme_58_SNPs:
Not Available

# Metabolic_Enzyme_58_General_References:
8552597; 9162081; 12665801

# Metabolic_Enzyme_58_References:
Not Available

# Metabolic_Enzyme_59_ID:
5879

# Metabolic_Enzyme_59_Name:
DNA ligase 3

# Metabolic_Enzyme_59_Synonyms:
DNA ligase III; Polydeoxyribonucleotide synthase [ATP] 3

# Metabolic_Enzyme_59_Gene_Name:
LIG3

# Metabolic_Enzyme_59_Protein_Sequence:
>DNA ligase 3
MAEQRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKL
ERARATTKKIEDLTELEGWEELEDNEKEQITQHIADLSSKAAGTPKKKAVVQAKLTTTGQ
VTSPVKGASFVTSTNPRKFSGFSAKPNNSGEAPSSPTPKRSLSSSKCDPRHKDCLLREFR
KLCAMVADNPSYNTKTQIIQDFLRKGSAGDGFHGDVYLTVKLLLPGVIKTVYNLNDKQIV
KLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQSKSFPPAAKSLLTIQEVDEFLLRLSKL
TKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNL
QDVVERVLHNAQEVEKEPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEI
KYDGERVQVHKNGDHFSYFSRSLKPVLPHKVAHFKDYIPQAFPGGHSMILDSEVLLIDNK
TGKPLPFGTLGVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIPNR
IMFSEMKRVTKALDLADMITRVIQEGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMA
DTADLVVLGAFYGQGSKGGMMSIFLMGCYDPGSQKWCTVTKCAGGHDDATLARLQNELDM
VKISKDPSKIPSWLKVNKIYYPDFIVPDPKKAAVWEITGAEFSKSEAHTADGISIRFPRC
TRIRDDKDWKSATNLPQLKELYQLSKEKADFTVVAGDEGSSTTGGSSEENKGPSGSAVSR
KAPSKPSASTKKAEGKLSNSNSKDGNMQTAKPSAMKVGEKLATKSSPVKVGEKRKAADET
LCQTKVLLDIFTGVRLYLPPSTPDFSRLRRYFVAFDGDLVQEFDMTSATHVLGSRDKNPA
AQQVSPEWIWACIRKRRLVAPC

# Metabolic_Enzyme_59_Number_of_Residues:
922

# Metabolic_Enzyme_59_Molecular_Weight:
102692

# Metabolic_Enzyme_59_Theoretical_pI:
9.17

# Metabolic_Enzyme_59_GO_Classification:
>>>
Function:  DNA ligase (ATP) activity
Function:  nucleic acid binding
Function:  DNA binding
Function:  DNA ligase (ATP) activity
Function:  DNA ligase (ATP) activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  DNA ligase activity
Function:  DNA ligase (ATP) activity
 ||
>>>
Process:  DNA recombination
Process:  DNA repair
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  DNA metabolism
Process:  DNA replication
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus
Component:  cell
Component:  intracellular

# Metabolic_Enzyme_59_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_59_Specific_Function:
Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents

# Metabolic_Enzyme_59_Pathway:
Not Available

# Metabolic_Enzyme_59_Reaction:
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m

# Metabolic_Enzyme_59_Pfam_Domain_Function:
PF04679:DNA_ligase_A_C;
PF01068:DNA_ligase_A_M;
PF04675:DNA_ligase_A_N;
PF00645:zf-PARP

# Metabolic_Enzyme_59_Signals:
None

# Metabolic_Enzyme_59_Transmembrane_Regions:
None

# Metabolic_Enzyme_59_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_59_EC_Link:
EC 6.5.1.1

# Metabolic_Enzyme_59_GenBank_ID_Protein:
860963

# Metabolic_Enzyme_59_SwissProt_ID:
DNL3_HUMAN (P49916)

# Metabolic_Enzyme_59_swissprot_Name:
Not Available

# Metabolic_Enzyme_59_Genecard_id:
LIG3

# Metabolic_Enzyme_59_Geneatlas_id:
LIG3

# Metabolic_Enzyme_59_hgnc_id:
HGNC:6600

# Metabolic_Enzyme_59_PDB_ID:
Not Available

# Metabolic_Enzyme_59_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_59_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_59_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_59_Gene_Sequence:
>2769 bp
ATGGCTGAGCAACGGTTCTGTGTGGACTATGCCAAGCGTGGCACAGCTGGCTGCAAAAAA
TGCAAGGAAAAGATTGTGAAGGGCGTATGCCGAATTGGCAAAGTGGTGCCCAATCCCTTC
TCAGAGTCTGGGGGTGATATGAAAGAGTGGTACCACATTAAATGCATGTTTGAGAAACTA
GAGCGGGCCCGGGCCACCACAAAAAAAATCGAGGACCTCACAGAGCTGGAAGGCTGGGAA
GAGCTGGAAGATAATGAGAAGGAACAGATAACCCAGCACATTGCAGATCTGTCTTCTAAG
GCAGCAGGTACACCAAAGAAGAAAGCTGTTGTCCAGGCTAAGTTGACAACCACTGGCCAG
GTGACTTCTCCAGTGAAAGGCGCCTCATTTGTCACCAGTACCAATCCCCGGAAATTTTCT
GGCTTTTCAGCCAAGCCCAACAACTCTGGGGAAGCCCCCTCGAGCCCCACCCCTAAGAGA
AGTCTGTCTTCAAGCAAATGTGACCCCAGGCATAAGGACTGTCTGCTACGGGAGTTTCGA
AAGTTATGCGCCATGGTGGCCGATAATCCTAGCTACAACACGAAGACCCAGATCATCCAG
GACTTCCTTCGGAAAGGCTCAGCAGGAGATGGTTTCCACGGTGATGTGTACCTAACAGTG
AAGCTGCTGCTGCCAGGAGTCATTAAGACTGTTTACAACTTGAACGATAAGCAGATTGTG
AAGCTTTTCAGTCGCATTTTTAACTGCAACCCAGATGATATGGCACGGGACCTAGAGCAG
GGTGACGTGTCAGAGACAATCAGAGTCTTCTTTGAGCAGAGCAAGTCTTTCCCCCCAGCT
GCCAAGAGCCTCCTTACCATCCAGGAAGTGGATGAGTTCCTTCTGCGGCTGTCCAAGCTC
ACCAAGGAGGATGAGCAGCAACAGGCCCTACAGGACATTGCCTCCAGGTGTACAGCCAAT
GACCTTAAATGCATCATCAGGTTGATCAAACATGATCTGAAGATGAACTCAGGTGCAAAA
CATGTGTTAGACGCCCTTGACCCCAATGCCTATGAAGCCTTCAAAGCCTCGCGCAACCTG
CAGGATGTGGTGGAGCGGGTCCTTCACAACGCGCAGGAGGTGGAGAAGGAGCCGGGCCAG
AGACGAGCTCTGAGCGTCCAGGCCTCGCTGATGACACCTGTGCAGCCCATGTTGGCGGAG
GCCTGCAAGTCCGTTGAGTATGCAATGAAGAAATGTCCCAATGGCATGTTCTCTGAGATC
AAGTACGATGGAGAGCGAGTCCAGGTGCATAAGAATGGAGACCACTTCAGCTACTTCAGC
CGCAGTCTCAAGCCCGTCCTTCCTCACAAGGTGGCCCACTTTAAGGACTACATTCCCCAG
GCTTTTCCTGGGGGCCACAGCATGATCTTGGATTCTGAAGTGCTTCTGATTGACAACAAG
ACAGGCAAACCACTGCCCTTTGGGACTCTGGGAGTACACAAGAAAGCAGCCTTCCAGGAT
GCTAATGTCTGCCTGTTTGTTTTTGATTGTATCTACTTTAATGATGTCAGCTTGATGGAC
AGACCTCTGTGTGAGCGGCGGAAGTTTCTTCATGACAACATGGTTGAAATTCCAAACCGG
ATCATGTTCTCAGAAATGAAGCGAGTCACAAAAGCTTTGGACTTGGCTGACATGATAACC
CGGGTGATCCAGGAGGGATTGGAGGGGCTGGTGCTGAAGGATGTGAAGGGTACATATGAG
CCTGGGAAGCGGCACTGGCTGAAAGTGAAGAAAGACTATTTGAACGAGGGGGCCATGGCC
GACACAGCTGACCTGGTGGTCCTTGGAGCCTTCTATGGGCAAGGGAGCAAAGGCGGCATG
ATGTCAATCTTCCTCATGGGCTGCTACGACCCTGGCAGCCAGAAGTGGTGCACAGTCACC
AAGTGTGCAGGAGGCCATGATGATGCCACGCTTGCCCGCCTGCAGAATGAACTAGACATG
GTGAAGATCAGCAAGGACCCCAGCAAAATACCCAGCTGGTTGAAGGTCAACAAGATCTAC
TATCCTGACTTCATCGTCCCAGACCCAAAGAAAGCTGCCGTGTGGGAGATCACAGGGGCT
GAATTCTCCAAATCGGAGGCTCATACAGCTGACGGGATCTCCATCCGATTCCCTCGCTGC
ACCCGAATCCGAGATGATAAGGACTGGAAATCTGCCACTAACCTTCCCCAACTCAAGGAA
CTGTACCAGTTGTCCAAGGAGAAGGCAGACTTCACTGTAGTGGCTGGAGATGAGGGGAGC
TCCACTACAGGGGGTAGCAGTGAAGAGAATAAGGGTCCCTCAGGGTCTGCTGTGTCCCGC
AAGGCCCCCAGCAAGCCCTCAGCCAGTACCAAGAAAGCAGAAGGGAAGCTGAGTAACTCC
AACAGCAAAGATGGCAACATGCAGACTGCAAAGCCTTCCGCTATGAAGGTGGGGGAGAAG
CTGGCCACAAAGTCTTCTCCAGTGAAAGTAGGGGAGAAGCGGAAAGCTGCTGATGAGACG
CTGTGCCAAACAAAGGTATTGCTGGACATCTTCACTGGGGTGCGGCTTTACTTGCCACCC
TCCACACCAGACTTCAGCCGTCTCAGACGCTACTTTGTGGCATTCGACGGGGACCTGGTA
CAGGAATTTGATATGACTTCAGCCACGCACGTGCTGGGTAGCAGGGACAAGAACCCTGCG
GCCCAGCAGGTCTCCCCAGAGTGGATTTGGGCATGTATCCGGAAACGGAGACTGGTAGCT
CCCTGCTAG

# Metabolic_Enzyme_59_GenBank_ID_Gene:
X84740

# Metabolic_Enzyme_59_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_59_Locus:
17q11.2-q12

# Metabolic_Enzyme_59_SNPs:
rs4986973; rs3136025; rs3744356; rs1076992; rs3136022; rs4986976; rs3135988; rs4796030; rs1052536; rs9898719; rs3135960; rs16970536; rs12945428; rs3135958; rs3135998; rs2066505; rs3135989; rs3135992; rs2074522; rs3135980; rs11868699; rs3136011; rs2074517; rs3135972; rs2074521; rs3136000; rs3135977; rs3135986; rs3136026; rs3136001; rs3136024; rs3136031; rs2074516; rs3135993; rs3136027; rs3136005; rs3135968; rs3135983; rs3135966; rs2074518; rs3135984; rs3135974; rs3135967; rs3136002; rs3135962; rs3136018; rs3135965; rs3135985; rs16970512; rs3135981; rs3136003; rs3136034; rs3135964; rs3136023; rs3135996; rs3136007; rs3136014; rs3136035; rs3135963; rs3135982; rs3136032; rs3135990; rs3136020; rs3136009; rs3135970; rs3135991; rs3136028; rs4986975; rs3136006; rs1003918; rs9895135; rs1802880; rs4986974; rs36021499; rs35501315; rs35956074; rs2066504; rs3084117; rs9910720; rs5820097; rs3135959; rs34885824; rs35202391; rs3136033; rs3135973; rs34608528; rs3135999; rs3136029; rs34029311; rs3135995; rs3136030; rs2074514; rs3136004; rs3136013; rs3785753; rs3136008; rs34258855; rs35262612; rs3135969; rs12150248; rs3136017; rs2879347; rs3136010; rs12941420; rs35195908; rs16970494; rs35406467; rs3135997; rs3135976; rs3135971; rs3136016; rs3135979; rs2014060; rs3135975; rs34568492; rs3135987; rs36027201; rs3136015; rs3136021; rs3135994; rs35610965; rs3136019; rs2074515; rs3136012; rs3135978; rs12952527; rs35071763; rs12325783; rs12947086; rs12948362; rs16970540; rs1859248; rs2074519; rs2074520; rs35426973; rs35744965; rs35903939; rs3744357; rs3744358; rs3744359; rs8077161; rs8079452; rs9167; rs978202; rs9915258

# Metabolic_Enzyme_59_General_References:
7760816; 7565692

# Metabolic_Enzyme_59_References:
Not Available

# Metabolic_Enzyme_60_ID:
5880

# Metabolic_Enzyme_60_Name:
Aspartyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_60_Synonyms:
Aspartate--tRNA ligase; AspRS; Cell proliferation-inducing gene 40 protein

# Metabolic_Enzyme_60_Gene_Name:
DARS

# Metabolic_Enzyme_60_Protein_Sequence:
>AspartyltRNA synthetase, cytoplasmic
MPSASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVV
WVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVV
RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRL
DNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYF
KNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYH
EVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGV
EMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFM
RGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLF
LGLHNVRQTSMFPRDPKRLTP

# Metabolic_Enzyme_60_Number_of_Residues:
501

# Metabolic_Enzyme_60_Molecular_Weight:
57137

# Metabolic_Enzyme_60_Theoretical_pI:
6.52

# Metabolic_Enzyme_60_GO_Classification:
>>>
Function:  nucleic acid binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  aspartate-tRNA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  aspartyl-tRNA aminoacylation
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_60_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_60_Specific_Function:
ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)

# Metabolic_Enzyme_60_Pathway:
map00252  Alanine and aspartate metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_60_Reaction:
ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)

# Metabolic_Enzyme_60_Pfam_Domain_Function:
PF00152:tRNA-synt_2;
PF01336:tRNA_anti

# Metabolic_Enzyme_60_Signals:
None

# Metabolic_Enzyme_60_Transmembrane_Regions:
None

# Metabolic_Enzyme_60_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_60_EC_Link:
EC 6.1.1.12

# Metabolic_Enzyme_60_GenBank_ID_Protein:
179102

# Metabolic_Enzyme_60_SwissProt_ID:
SYDC_HUMAN (P14868)

# Metabolic_Enzyme_60_swissprot_Name:
Not Available

# Metabolic_Enzyme_60_Genecard_id:
DARS

# Metabolic_Enzyme_60_Geneatlas_id:
DARS

# Metabolic_Enzyme_60_hgnc_id:
HGNC:2678

# Metabolic_Enzyme_60_PDB_ID:
Not Available

# Metabolic_Enzyme_60_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_60_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_60_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_60_Gene_Sequence:
>1503 bp
ATGCCCAGCGCCACGCAGCGCAAGAGTCAGGAGAAGCCGCGGGAGATCATGGACGCGGCG
GAAGATTATGCTAAAGAGAGATATGGAATATCTTCAATGATACAATCACAAGAAAAACCA
GATCGAGTTTTGGTTCGGGTTAGAGACTTGACAATACAAAAAGCTGATGAAGTTGTTTGG
GTACGTGCAAGAGTTCATACAAGCAGAGCTAAAGGGAAACAGTGCTTCTTAGTCCTACGT
CAGCAGCAGTTTAATGTCCAGGCTCTTGTGGCGGTGGGAGACCATGCAAGCAAGCAGATG
GTTAAATTTGCTGCCAACATCAACAAAGAGAGCATTGTGGATGTAGAAGGTGTTGTGAGA
AAAGTGAATCAGAAAATTGGAAGCTGTACACAGCAAGACGTTGAGTTACATGTTCAGAAG
ATTTATGTGATCAGTTTGGCTGAACCCCGTCTGCCCCTGCAGCTGGATGATGCTGTTCGG
CCTGAGCAAGAAGGAGAAGAGGAAGGAAGAGCTACTGTTAACCAGGATACAAGATTAGAC
AACAGAGTCATTGATCTTAGGACATCAACTAGTCAGGCAGTCTTCCGTCTCCAGTCTGGC
ATCTGCCATCTCTTCCGAGAAACTTTAATTAACAAAGGTTTTGTGGAAATCCAAACTCCT
AAAATTATTTCAGCTGCCAGTGAAGGAGGAGCCAATGTTTTTACTGTGTCATATTTTAAA
AATAATGCATACCTGGCTCAGTCCCCACAGCTATATAAGCAAATGTGCATTTGTGCTGAT
TTTGAGAAGGTTTTCTCTATTGGACCAGTATTCAGAGCGGAAGACTCTAATACCCATAGA
CATCTAACTGAGTTTGTTGGTTTGGACATTGAAATGGCTTTTAATTACCATTACCACGAA
GTTATGGAAGAAATTGCTGACACCATGGTACAAATATTCAAAGGACTTCAAGAAAGGTTT
CAGACTGAAATTCAAACAGTGAATAAACAGTTCCCATGTGAGCCATTCAAATTTTTGGAG
CCAACTCTAAGACTAGAATATTGTGAAGCATTGGCTATGCTTAGGGAAGCTGGAGTCGAA
ATGGGAGATGAAGACGATCTGAGCACACCAAATGAAAAGCTGTTGGGTCATTTGGTAAAG
GAAAAGTATGATACAGATTTTTATATTCTTGATAAATATCCATTGGCTGTAAGACCTTTC
TATACCATGCCTGACCCAAGAAATCCCAAACAGTCCAAGTCTTACGATATGTTCATGAGA
GGAGAAGAAATATTGTCAGGAGCTCAAAGAATACATGATCCTCAACTGCTAACAGAGAGA
GCTTTACATCATGGAAATGATTTGGAGAAAATTAAGGCTTACATTGATTCCTTCCGCTTT
GGAGCCCCTCCTCATGCTGGTGGAGGCATTGGATTGGAACGAGTTACTATGCTGTTTCTG
GGATTGCATAATGTTCGTCAGACCTCCATGTTCCCTCGTGATCCCAAACGACTCACTCCT
TAA

# Metabolic_Enzyme_60_GenBank_ID_Gene:
J05032

# Metabolic_Enzyme_60_Chromosome_Location:
Not Available

# Metabolic_Enzyme_60_Locus:
Not Available

# Metabolic_Enzyme_60_SNPs:
Not Available

# Metabolic_Enzyme_60_General_References:
2674137

# Metabolic_Enzyme_60_References:
Not Available

# Metabolic_Enzyme_61_ID:
5881

# Metabolic_Enzyme_61_Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B

# Metabolic_Enzyme_61_Synonyms:
DPDE4; PDE32

# Metabolic_Enzyme_61_Gene_Name:
PDE4B

# Metabolic_Enzyme_61_Protein_Sequence:
>cAMPspecific 3',5'cyclic phosphodiesterase 4
BMKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQ
SERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLV
LHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSV
RNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTY
RSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKK
KKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYS
HNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTH
VLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH
LAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVT
SSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGME
ISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQS
PSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSL
GETDIDIATEDKSPVDT

# Metabolic_Enzyme_61_Number_of_Residues:
736

# Metabolic_Enzyme_61_Molecular_Weight:
83344

# Metabolic_Enzyme_61_Theoretical_pI:
4.89

# Metabolic_Enzyme_61_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_61_General_Function:
Not Available

# Metabolic_Enzyme_61_Specific_Function:
May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents

# Metabolic_Enzyme_61_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_61_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_61_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_61_Signals:
None

# Metabolic_Enzyme_61_Transmembrane_Regions:
None

# Metabolic_Enzyme_61_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_61_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_61_GenBank_ID_Protein:
347122

# Metabolic_Enzyme_61_SwissProt_ID:
PDE4B_HUMAN (Q07343)

# Metabolic_Enzyme_61_swissprot_Name:
Not Available

# Metabolic_Enzyme_61_Genecard_id:
PDE4B

# Metabolic_Enzyme_61_Geneatlas_id:
PDE4B

# Metabolic_Enzyme_61_hgnc_id:
HGNC:8781

# Metabolic_Enzyme_61_PDB_ID:
Not Available

# Metabolic_Enzyme_61_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_61_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_61_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_61_Gene_Sequence:
>2211 bp
ATGAAGAAAAGCAGGAGTGTGATGACGGTGATGGCTGATGATAATGTTAAAGATTATTTT
GAATGTAGCTTGAGTAAATCCTACAGTTCTTCCAGTAACACACTTGGGATCGACCTCTGG
AGAGGGAGAAGGTGTTGCTCAGGAAACTTACAGTTACCACCACTGTCTCAAAGACAGAGT
GAAAGGGCAAGGACTCCTGAGGGAGATGGTATTTCCAGGCCGACCACACTGCCTTTGACA
ACGCTTCCAAGCATTGCTATTACAACTGTAAGCCAGGAGTGCTTTGATGTGGAAAATGGC
CCTTCCCCAGGTCGGAGTCCACTGGATCCCCAGGCCAGCTCTTCCGCTGGGCTGGTACTT
CACGCCACCTTTCCTGGGCACAGCCAGCGCAGAGAGTCATTTCTCTACAGATCAGACAGC
GACTATGACTTGTCACCAAAGGCGATGTCGAGAAACTCTTCTCTTCCAAGCGAGCAACAC
GGCGATGACTTGATTGTAACTCCTTTTGCCCAGGTCCTTGCCAGCTTGCGAAGTGTGAGA
AACAACTTCACTATACTGACAAACCTTCATGGTACATCTAACAAGAGGTCCCCAGCTGCT
AGTCAGCCTCCTGTCTCCAGAGTCAACCCACAAGAAGAATCTTATCAAAAATTAGCAATG
GAAACGCTGGAGGAATTAGACTGGTGTTTAGACCAGCTAGAGACCATACAGACCTACCGG
TCTGTCAGTGAGATGGCTTCTAACAAGTTCAAAAGAATGCTGAACCGGGAGCTGACACAC
CTCTCAGAGATGAGCCGATCAGGGAACCAGGTGTCTGAATACATTTCAAATACTTTCTTA
GACAAGCAGAATGATGTGGAGATCCCATCTCCTACCCAGAAAGACAGGGAGAAAAAGAAA
AAGCAGCAGCTCATGACCCAGATAAGTGGAGTGAAGAAATTAATGCATAGTTCAAGCCTA
AACAATACAAGCATCTCACGCTTTGGAGTCAACACTGAAAATGAAGATCACCTGGCCAAG
GAGCTGGAAGACCTGAACAAATGGGGTCTTAACATCTTTAATGTGGCTGGATATTCTCAC
AATAGACCCCTAACATGCATCATGTATGCTATATTCCAGGAAAGAGACCTCCTAAAGACA
TTCAGAATCTCATCTGACACATTTATAACCTACATGATGACTTTAGAAGACCATTACCAT
TCTGACGTGGCATATCACAACAGCCTGCACGCTGCTGATGTAGCCCAGTCGACCCATGTT
CTCCTTTCTACACCAGCATTAGACGCTGTCTTCACAGATTTGGAGATCCTGGCTGCCATT
TTTGCAGCTGCCATCCATGACGTTGATCATCCTGGAGTCTCCAATCAGTTTCTCATCAAC
ACAAATTCAGAACTTGCTTTGATGTATAATGATGAATCTGTGTTGGAAAATCATCACCTT
GCTGTGGGTTTCAAACTGCTGCAAGAAGAACACTGTGACATCTTCATGAATCTCACCAAG
AAGCAGCGTCAGACACTCAGGAAGATGGTTATTGACATGGTGTTAGCAACTGATATGTCT
AAACATATGAGCCTGCTGGCAGACCTGAAGACAATGGTAGAAACGAAGAAAGTTACAAGT
TCAGGCGTTCTTCTCCTAGACAACTATACCGATCGCATTCAGGTCCTTCGCAACATGGTA
CACTGTGCAGACCTGAGCAACCCCACCAAGTCCTTGGAATTGTATCGGCAATGGACAGAC
CGCATCATGGAGGAATTTTTCCAGCAGGGAGACAAAGAGCGGGAGAGGGGAATGGAAATT
AGCCCAATGTGTGATAAACACACAGCTTCTGTGGAAAAATCCCAGGTTGGTTTCATCGAC
TACATTGTCCATCCATTGTGGGAGACATGGGCAGATTTGGTACAGCCTGATGCTCAGGAC
ATTCTCGATACCTTAGAAGATAACAGGAACTGGTATCAGAGCATGATACCTCAAAGTCCC
TCACCACCACTGGACGAGCAGAACAGGGACTGCCAGGGTCTGATGGAGAAGTTTCAGTTT
GAACTGACTCTCGATGAGGAAGATTCTGAAGGACCTGAGAAGGAGGGAGAGGGACACAGC
TATTTCAGCAGCACAAAGACGCTTTGTGTGATTGATCCAGAAAACAGAGATTCCCTGGGA
GAGACTGACATAGACATTGCAACAGAAGACAAGTCCCCCGTGGATACATAA

# Metabolic_Enzyme_61_GenBank_ID_Gene:
L20966

# Metabolic_Enzyme_61_Chromosome_Location:
Not Available

# Metabolic_Enzyme_61_Locus:
Not Available

# Metabolic_Enzyme_61_SNPs:
Not Available

# Metabolic_Enzyme_61_General_References:
8413254; 9371714; 8384210

# Metabolic_Enzyme_61_References:
Not Available

# Metabolic_Enzyme_62_ID:
5578

# Metabolic_Enzyme_62_Name:
3'(2'),5'-bisphosphate nucleotidase 1

# Metabolic_Enzyme_62_Synonyms:
Bisphosphate 3'- nucleotidase 1; PAP-inositol-1,4-phosphatase; PIP

# Metabolic_Enzyme_62_Gene_Name:
BPNT1

# Metabolic_Enzyme_62_Protein_Sequence:
>3'2',5'bisphosphate nucleotidase 1
MASSNTVLMRLVASAYSIAQKAGMIVRRVIAEGDLGIVEKTCATDLQTKADRLAQMSICS
SLARKFPKLTIIGEEDLPSEEVDQELIEDSQWEEILKQPCPSQYSAIKEEDLVVWVDPLD
GTKEYTEGLLDNVTVLIGIAYEGKAIAGVINQPYYNYEAGPDAVLGRTIWGVLGLGAFGF
QLKEVPAGKHIITTTRSHSNKLVTDCVAAMNPDAVLRVGGAGNKIIQLIEGKASAYVFAS
PGCKKWDTCAPEVILHAVGGKLTDIHGNVLQYHKDVKHMNSAGVLATLRNYDYYASRVPE
SIKNALVP

# Metabolic_Enzyme_62_Number_of_Residues:
308

# Metabolic_Enzyme_62_Molecular_Weight:
33393

# Metabolic_Enzyme_62_Theoretical_pI:
5.41

# Metabolic_Enzyme_62_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  inositol or phosphatidylinositol phosphatase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_62_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_62_Specific_Function:
Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4- trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6

# Metabolic_Enzyme_62_Pathway:
map00920  Sulfur metabolism

# Metabolic_Enzyme_62_Reaction:
adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate

# Metabolic_Enzyme_62_Pfam_Domain_Function:
PF00459:Inositol_P

# Metabolic_Enzyme_62_Signals:
1-19

# Metabolic_Enzyme_62_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_62_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_62_EC_Link:
EC 3.1.3.7

# Metabolic_Enzyme_62_GenBank_ID_Protein:
4325316

# Metabolic_Enzyme_62_SwissProt_ID:
BPNT1_HUMAN (O95861)

# Metabolic_Enzyme_62_swissprot_Name:
Not Available

# Metabolic_Enzyme_62_Genecard_id:
BPNT1

# Metabolic_Enzyme_62_Geneatlas_id:
BPNT1

# Metabolic_Enzyme_62_hgnc_id:
HGNC:1096

# Metabolic_Enzyme_62_PDB_ID:
1JP4

# Metabolic_Enzyme_62_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_62_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_62_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_62_Gene_Sequence:
>927 bp
ATGGCTTCCAGTAACACTGTGTTGATGCGGTTGGTAGCCTCCGCATATTCTATTGCTCAA
AAGGCAGGAATGATAGTCAGACGTGTTATTGCTGAAGGAGACCTGGGTATTGTGGAGAAG
ACCTGTGCAACAGACCTGCAGACCAAAGCTGACCGATTGGCACAGATGAGCATATGTTCT
TCATTGGCCCGGAAATTCCCCAAACTCACAATTATAGGGGAAGAGGATCTGCCTTCTGAG
GAAGTGGATCAAGAGCTGATTGAAGACAGTCAGTGGGAAGAAATACTGAAGCAACCATGC
CCATCGCAGTACAGTGCTATTAAAGAAGAAGATCTCGTGGTCTGGGTTGATCCTCTGGAT
GGAACCAAGGAATATACCGAAGGTCTTCTTGACAATGTAACAGTTCTTATTGGAATTGCT
TATGAAGGAAAAGCCATAGCAGGAGTTATTAACCAGCCATATTACAACTATGAGGCAGGA
CCAGATGCTGTGTTGGGGAGGACAATCTGGGGAGTTTTAGGTTTAGGCGCCTTTGGGTTT
CAGCTGAAAGAAGTCCCTGCTGGGAAACACATTATCACAACTACTCGATCCCATAGCAAC
AAGTTGGTTACTGACTGTGTTGCTGCTATGAACCCCGATGCTGTGCTGCGAGTAGGAGGA
GCAGGAAATAAGATTATTCAGCTGATTGAAGGCAAAGCCTCTGCTTATGTATTTGCAAGT
CCTGGTTGTAAGAAGTGGGATACTTGTGCTCCAGAAGTTATTTTACATGCTGTGGGAGGC
AAGTTAACCGATATCCATGGGAATGTTCTTCAGTACCACAAGGATGTGAAGCATATGAAC
TCTGCAGGAGTCCTGGCCACACTGAGGAATTATGACTACTATGCAAGCCGAGTTCCAGAA
TCTATTAAAAATGCACTTGTTCCTTAA

# Metabolic_Enzyme_62_GenBank_ID_Gene:
AF125042

# Metabolic_Enzyme_62_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_62_Locus:
1q41

# Metabolic_Enzyme_62_SNPs:
rs904327; rs2647471; rs2647472; rs2789785; rs12133210; rs2647465; rs2889876; rs12568334; rs6661761; rs6704420; rs12136801; rs1146773; rs904328; rs2053250; rs1146774; rs17563262; rs12116864; rs1611863; rs6673800; rs12145672; rs12135677; rs34406824; rs7524161; rs11586452; rs2577152; rs11803960; rs2647466; rs7538757; rs12734813; rs12407434; rs35038735; rs12404973; rs12086370; rs34887640; rs3201549; rs12138628; rs12408053; rs12410587; rs35675420; rs1137752; rs34639450; rs12046760; rs1137753; rs2577132; rs3055553; rs9431224; rs12081255; rs2577133; rs10702348; rs3201546; rs2577131; rs12037811; rs3055555; rs34628672; rs2789786; rs17856551; rs1051435; rs35221551; rs11118493; rs35619743; rs12033581; rs12038562; rs6667047; rs12726102; rs35685939; rs12757995; rs7516345; rs7530481; rs11292010; rs34257886; rs41274792; rs9430910; rs4268361; rs17856552; rs35431487; rs9969996; rs2486327; rs41274790; rs9430911; rs34136285; rs34674672; rs34025792; rs2247212; rs41274794; rs35600968; rs2577135; rs35546692; rs11405609; rs9430912; rs1612813; rs34118944; rs7515463; rs2789787; rs7531190; rs35894683; rs34255218; rs10648388; rs28445890; rs9430913; rs34672561; rs12066555; rs12026465; rs7531770; rs35677563; rs34649864; rs34638408; rs12127171; rs10157645; rs17007107; rs34116851; rs34980841; rs7516830; rs7549576

# Metabolic_Enzyme_62_General_References:
10224133

# Metabolic_Enzyme_62_References:
Not Available

# Metabolic_Enzyme_63_ID:
5232

# Metabolic_Enzyme_63_Name:
Cytosolic 5'-nucleotidase 1B

# Metabolic_Enzyme_63_Synonyms:
Cytosolic 5'-nucleotidase IB; cN1B; cN-IB; Autoimmune infertility-related protein

# Metabolic_Enzyme_63_Gene_Name:
NT5C1B

# Metabolic_Enzyme_63_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
BMSQTSLKQKKNEPGMRSSKESLEAEKRKESDKTGVRLSNQMRRAVNPNHSLRCCPFQGH
SSCRRCLCAAEGTALGPCHTIRIYIHMCLLWEQGQQITMMRGSQESSLRKTDSRGYLVRS
QWSRISRSPSTKAPSIDEPRSRNTSAKLPSSSTSSRTPSTSPSLHDSSPPPLSGQPSLQP
PASPQLPRSLDSRPPTPPEPDPGSRRSTKMQENPEAWAQGIVREIRQTRDSQPLEYSRTS
PTEWKSSSQRRGIYPASTQLDRNSLSEQQQQQREDEDDYEAAYWASMRSFYEKNPSCSRP
WPPKPKNAITIALSSCALFNMVDGRKIYEQEGLEKYMEYQLTNENVILTPGPAFRFVKAL
QYVNARLRDLYPDEQDLFDIVLMTNNHAQVGVRLINSVNHYGLLIDRFCLTGGKDPIGYL
KAYLTNLYIAADSEKVQEAIQEGIASATMFDGAKDMAYCDTQLRVAFDGDAVLFSDESEH
FTKEHGLDKFFQYDTLCESKPLAQGPLKGFLEDLGRLQKKFYAKNERLLCPIRTYLVTAR
SAASSGARVLKTLRRWGLEIDEALFLAGAPKSPILVKIRPHIFFDDHMFHIEGAQRLGSI
AAYGFNKKFSS

# Metabolic_Enzyme_63_Number_of_Residues:
610

# Metabolic_Enzyme_63_Molecular_Weight:
68804

# Metabolic_Enzyme_63_Theoretical_pI:
9.03

# Metabolic_Enzyme_63_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_63_General_Function:
Not Available

# Metabolic_Enzyme_63_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels

# Metabolic_Enzyme_63_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_63_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_63_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_63_Signals:
None

# Metabolic_Enzyme_63_Transmembrane_Regions:
None

# Metabolic_Enzyme_63_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_63_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_63_GenBank_ID_Protein:
13774961

# Metabolic_Enzyme_63_SwissProt_ID:
5NT1B_HUMAN (Q96P26)

# Metabolic_Enzyme_63_swissprot_Name:
Not Available

# Metabolic_Enzyme_63_Genecard_id:
NT5C1B

# Metabolic_Enzyme_63_Geneatlas_id:
NT5C1B

# Metabolic_Enzyme_63_hgnc_id:
HGNC:17818

# Metabolic_Enzyme_63_PDB_ID:
Not Available

# Metabolic_Enzyme_63_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_63_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_63_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_63_Gene_Sequence:
>1699 bp
GGGCAAAAATGTGGATAACAACAAAAGAATTTCAACAGGTAAAAAAATGAGTCAAACATC
TCTCAAACAGAAAAAGAATGAGCCCGGAATGAGGTCCTCAAAAGAGAGTCTAGAAGCAGA
AAAAAGAAAGGAATCTGACAAAACAGGAGTTCGTCTGAGCAATCAGGGATCACAAGAATC
ATCACTGCGGAAGACAGACTCTCGAGGGTACCTTGTGCGCAGTCAATGGTCTAGAATATC
CCGGAGCCCATCCACCAAGGCTCCATCCATAGATGAGCCTAGAAGCAGGAACACCAGTGC
TAAGCTCCCCAGCAGCTCCACGAGCTCCCGGACTCCATCCACCTCCCCAAGCCTGCATGA
CTCCTCACCGCCGCCGCTGTCCGGGCAGCCCTCGCTCCAGCCACCCGCGTCGCCCCAGCT
GCCCCGGTCGCTGGACTCGCGGCCTCCCACGCCCCCAGAGCCCGATCCTGGCTCCCGGCG
CAGCACCAAAATGCAAGAAAATCCGGAGGCCTGGGCCCAAGGCATCGTGCGGGAAATCCG
CCAGACCCGGGACTCGCAGCCGCTGGAATATTCGCGCACGTCCCCCACCGAGTGGAAGTC
CTCCAGCCAGCGCAGGGGGATCTACCCCGCCTCCACCCAGCTGGACCGCAACTCTCTGTC
CGAGCAGCAGCAGCAGCAGCGGGAGGACGAAGACGACTACGAAGCTGCCTACTGGGCATC
CATGAAGTCGTTCTACGAAAAGAACCCGAGCTGCTGGCGCCCCTGGCCGCCCAAACCCAA
GAACGCCATCACCATTGCTCTCTCATCCTGCGCGCTCTTCAACATGGTGGACGGCAGGAA
AATCTACGAGCAAGAGGGTCTGGAAAAGTACATGGAGTATCAGCTCACCAATGAGAACGT
CATCCTGACCCCGGGCCCGGCGTTCCGTTTCGTCAAGGCACTACAGTATGTCAATGCTAG
ACTCCGTGATCTATATCCTGATGAACAGGACTTATTTGATATTGTACTGATGACTAATAA
CCATGCCCAAGTGGGAGTGCGGCTTATAAACAGCGTCAATCACTACGGCTTACTGATTGA
CCGCTTCTGTCTGACCGGGGGAAAAGACCCCATTGGCTATTTGAAGGCATATCTTACCAA
CTTGTATATTGCTGCAGATTCTGAAAAAGTGCAAGAGGCAATACAAGAAGGTATTGCCTC
TGCGACAATGTTTGATGGAGCCAAAGACATGGCTTACTGTGACACTCAGCTCCGTGTAGC
CTTTGATGGGGATGCTGTCCTCTTCTCTGATGAGTCTGAACATTTTACCAAGGAGCATGG
GCTGGACAAATTCTTCCAGTATGATACATTATGTGAAAGTAAGCCTCTTGCTCAGGGTCC
CCTAAAAGGCTTTCTGGAAGATTTAGGCAGACTGCAAAAGAAGTTCTATGCCAAAAATGA
ACGGTTACTTTGTCCTATCAGGACCTACCTGGTTACAGCTAGGAGTGCAGCCAGTTCAGG
CGCCCGTGTGCTGAAAACCTTCCGACGCTGGGGTCTAGAGATAGACGAAGCTCTTTTCCT
TGCTGGAGCCCCCAAAAGTCCCATCTTGGTGAAGATCCGGCCCCACATCTTCTTTGATGA
CCACATGTTCCACATTGAAGGGGCACAGAGGTTAGGTTCCATCGCAGCTTATGGCTTTAA
TAAAAAATTCAGTAGTTAG

# Metabolic_Enzyme_63_GenBank_ID_Gene:
AF356185

# Metabolic_Enzyme_63_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_63_Locus:
2p24.2

# Metabolic_Enzyme_63_SNPs:
rs3902946; rs16985301; rs16985306; rs3747660; rs2346137; rs6720633; rs7594728; rs6531109; rs6710367; rs7557821; rs4832608; rs11893074; rs16985296; rs7561652; rs2317857; rs16985292; rs16985290; rs6741218; rs11096544; rs35590292; rs10183289; rs17752103; rs11885013; rs17701334; rs16985293; rs11903725; rs7604190; rs4832609; rs7592099; rs16985311; rs16985310; rs3810839; rs17852342; rs34254789; rs7594519; rs34129467; rs7605480; rs35165251; rs7603601; rs34836771; rs34186303; rs35711606; rs35729409; rs34953851; rs11291136; rs28474708; rs3046807; rs34660980; rs35519366; rs3046840; rs35419885; rs7557722; rs4300829; rs7592233; rs13020403; rs36121694; rs34127788; rs11889898; rs13403096; rs13411442; rs1373776; rs16985281; rs16985284; rs17751951; rs2346135; rs2346136; rs34722188; rs35805648; rs3810838; rs3910894

# Metabolic_Enzyme_63_General_References:
11690631

# Metabolic_Enzyme_63_References:
Not Available

# Metabolic_Enzyme_64_ID:
5882

# Metabolic_Enzyme_64_Name:
Ubiquitin-conjugating enzyme E2 D3

# Metabolic_Enzyme_64_Synonyms:
Ubiquitin-protein ligase D3; Ubiquitin carrier protein D3; Ubiquitin-conjugating enzyme E2-17 kDa 3; E2(17KB 3

# Metabolic_Enzyme_64_Gene_Name:
UBE2D3

# Metabolic_Enzyme_64_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 D3
MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDY
PFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLV
PEIARIYKTDRDKYNRISREWTQKYAM

# Metabolic_Enzyme_64_Number_of_Residues:
147

# Metabolic_Enzyme_64_Molecular_Weight:
16687

# Metabolic_Enzyme_64_Theoretical_pI:
7.95

# Metabolic_Enzyme_64_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_64_General_Function:
Not Available

# Metabolic_Enzyme_64_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53

# Metabolic_Enzyme_64_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_64_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_64_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_64_Signals:
None

# Metabolic_Enzyme_64_Transmembrane_Regions:
None

# Metabolic_Enzyme_64_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_64_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_64_GenBank_ID_Protein:
1145691

# Metabolic_Enzyme_64_SwissProt_ID:
UB2D3_HUMAN (P61077)

# Metabolic_Enzyme_64_swissprot_Name:
Not Available

# Metabolic_Enzyme_64_Genecard_id:
UBE2D3

# Metabolic_Enzyme_64_Geneatlas_id:
UBE2D3

# Metabolic_Enzyme_64_hgnc_id:
HGNC:12476

# Metabolic_Enzyme_64_PDB_ID:
1X23

# Metabolic_Enzyme_64_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_64_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_64_Subcellular_Location:
Not Available

# Metabolic_Enzyme_64_Gene_Sequence:
>444 bp
ATGGCGCTGAAACGGATTAATAAGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAA
TGTTCTGCAGGTCCAGTTGGGGATGATATGTTTCATTGGCAAGCCACAATTATGGGACCT
AATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAATTCATTTTCCTACAGACTAC
CCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGT
AATGGCAGCATTTGTCTCGATATTCTAAGATCACAGTGGTCGCCTGCTTTAACAATTTCT
AAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAACCCAGATGACCCCCTAGTG
CCAGAGATTGCACGGATCTATAAAACAGACAGAGATAAGTACAACAGAATATCTCGGGAA
TGGACTCAGAAGTATGCCATGTGA

# Metabolic_Enzyme_64_GenBank_ID_Gene:
U39318

# Metabolic_Enzyme_64_Chromosome_Location:
Not Available

# Metabolic_Enzyme_64_Locus:
Not Available

# Metabolic_Enzyme_64_SNPs:
Not Available

# Metabolic_Enzyme_64_General_References:
8530467

# Metabolic_Enzyme_64_References:
Not Available

# Metabolic_Enzyme_65_ID:
5883

# Metabolic_Enzyme_65_Name:
Asparaginyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_65_Synonyms:
Asparagine-- tRNA ligase; AsnRS

# Metabolic_Enzyme_65_Gene_Name:
NARS

# Metabolic_Enzyme_65_Protein_Sequence:
>AsparaginyltRNA synthetase, cytoplasmic
MVLAELYVSDREGSDATGDGTKEKPFKTGLKALMTVGKEPFPTIYVDSQKENERWNVISK
SQLKNIKKMWHREQMKSESREKKEAEDSLRREKNLEEAKKITIKNDPSLPEPKCVKIGAL
EGYRGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLADELCQCYNGVLLSTESSVA
VYGMLNLTPKGKQAPGGHELSCDFWELIGLAPAGGADNLINEESDVDVQLNNRHMMIRGE
NMSKILKARSMVTRCFRDHFFDRGYYEVTPPTLVQTQVEGGATLFKLDYFGEEAFLTQSS
QLYLETCLPALGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFLTFDDLLNRLEDLVCD
VVDRILKSPAGSIVHELNPNFQPPKRPFKRMNYSDAIVWLKEHDVKKEDGTFYEFGEDIP
EAPERLMTDTINEPILLCRFPVEIKSFYMQRCPEDSRLTESVDVLMPNVGEIVGGSMRIF
DSEEILAGYKREGIDPTPYYWYTDQRKYGTCPHGGYGLGLERFLTWILNRYHIRDVCLYP
RFVQRCTP

# Metabolic_Enzyme_65_Number_of_Residues:
548

# Metabolic_Enzyme_65_Molecular_Weight:
62944

# Metabolic_Enzyme_65_Theoretical_pI:
6.17

# Metabolic_Enzyme_65_GO_Classification:
>>>
Function:  aspartate-tRNA ligase activity
Function:  nucleic acid binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  asparagine-tRNA ligase activity
 ||
>>>
Process:  aspartyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  asparaginyl-tRNA aminoacylation
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_65_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_65_Specific_Function:
ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)

# Metabolic_Enzyme_65_Pathway:
map00252  Alanine and aspartate metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_65_Reaction:
ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)

# Metabolic_Enzyme_65_Pfam_Domain_Function:
PF00152:tRNA-synt_2;
PF01336:tRNA_anti

# Metabolic_Enzyme_65_Signals:
None

# Metabolic_Enzyme_65_Transmembrane_Regions:
None

# Metabolic_Enzyme_65_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_65_EC_Link:
EC 6.1.1.22

# Metabolic_Enzyme_65_GenBank_ID_Protein:
2764505

# Metabolic_Enzyme_65_SwissProt_ID:
SYNC_HUMAN (O43776)

# Metabolic_Enzyme_65_swissprot_Name:
Not Available

# Metabolic_Enzyme_65_Genecard_id:
NARS

# Metabolic_Enzyme_65_Geneatlas_id:
NARS

# Metabolic_Enzyme_65_hgnc_id:
HGNC:7643

# Metabolic_Enzyme_65_PDB_ID:
Not Available

# Metabolic_Enzyme_65_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_65_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_65_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_65_Gene_Sequence:
>1647 bp
ATGGTGCTAGCAGAGCTGTACGTCTCTGACCGAGAGGGAAGCGATGCCACGGGAGATGGA
ACCAAGGAGAAACCATTTAAAACAGGTCTAAAGGCTTTGATGACAGTAGGGAAAGAACCA
TTTCCTACCATTTACGTAGATTCACAAAAAGAAAATGAGAGGTGGAATGTTATTTCTAAA
TCACAGTTGAAGAACATTAAAAAGATGTGGCATAGGGAACAAATGAAGAGTGAATCCCGG
GAAAAGAAAGAGGCAGAAGATAGTTTACGAAGAGAAAAGAACCTGGAAGAAGCAAAGAAG
ATTACCATTAAAAATGATCCAAGTCTCCCAGAGCCAAAATGTGTGAAGATTGGTGCGTTA
GAAGGATATAGAGGCCAAAGAGTAAAGGTGTTTGGCTGGGTCCACAGGCTGCGCAGGCAA
GGAAAGAATTTAATGTTTCTGGTGTTGCGAGATGGTACAGGTTATCTTCAGTGTGTCTTG
GCGGATGAGTTGTGTCAGTGCTACAATGGAGTTCTCTTGTCCACGGAGAGCAGTGTTGCA
GTGTATGGAATGCTAAATCTTACCCCAAAGGGCAAGCAGGCTCCAGGTGGCCATGAGCTG
AGTTGTGACTTCTGGGAACTAATTGGGTTGGCCCCTGCTGGAGGAGCTGACAACCTGATC
AATGAGGAGTCTGACGTTGATGTCCAGCTCAACAACAGACACATGATGATCCGAGGAGAA
AACATGTCCAAAATCCTAAAAGCACGATCCATGGTCACCAGGTGCTTTAGAGATCACTTC
TTTGATAGGGGGTACTATGAAGTTACTCCTCCAACATTAGTGCAAACACAAGTAGAAGGT
GGTGCCACACTCTTCAAGCTTGACTATTTTGGGGAAGAGGCATTTTTGACTCAATCCTCT
CAGTTGTACTTGGAGACCTGCCTCCCAGCCCTGGGAGATGTTTTTTGTATTGCTCAGTCA
TACCGGGCAGAGCAGTCCAGAACACGAAGGCACCTGGCTGAGTACACTCACGTGGAAGCT
GAGTGTCCTTTCCTGACTTTTGACGACCTCCTGAACCGGTTGGAGGACTTGGTTTGTGAT
GTGGTAGATCGAATATTGAAGTCACCTGCAGGGAGCATAGTGCATGAGCTCAACCCGAAC
TTTCAGCCCCCCAAACGGCCTTTCAAACGGATGAACTATTCAGATGCTATCGTTTGGCTA
AAAGAACATGATGTAAAGAAAGAAGATGGAACTTTCTATGAATTTGGAGAAGATATCCCA
GAAGCTCCTGAGAGACTGATGACAGACACCATTAATGAACCAATCTTGCTGTGTCGATTT
CCTGTGGAGATCAAGTCCTTCTACATGCAGCGATGTCCTGAGGATTCCCGTCTTACTGAA
TCTGTCGACGTGTTGATGCCCAATGTTGGTGAGATTGTGGGAGGCTCAATGCGTATCTTT
GATAGTGAAGAAATACTGGCAGGTTATAAAAGGGAAGGGATTGACCCCACTCCCTATTAC
TGGTATACGGATCAGAGAAAATACGGTACATGTCCCCATGGAGGATATGGCTTGGGCTTG
GAACGATTCTTAACGTGGATTCTGAATAGGTATCACATCCGAGACGTGTGCTTATACCCT
CGATTTGTCCAGCGTTGCACGCCATAA

# Metabolic_Enzyme_65_GenBank_ID_Gene:
AJ000334

# Metabolic_Enzyme_65_Chromosome_Location:
Not Available

# Metabolic_Enzyme_65_Locus:
Not Available

# Metabolic_Enzyme_65_SNPs:
Not Available

# Metabolic_Enzyme_65_General_References:
9421509; 9801298

# Metabolic_Enzyme_65_References:
Not Available

# Metabolic_Enzyme_66_ID:
5884

# Metabolic_Enzyme_66_Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 7B

# Metabolic_Enzyme_66_Synonyms:
Not Available

# Metabolic_Enzyme_66_Gene_Name:
PDE7B

# Metabolic_Enzyme_66_Protein_Sequence:
>cAMPspecific 3',5'cyclic phosphodiesterase 7
BMSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTY
SGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDI
FLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAA
DVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNM
SVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLH
NKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEI
SPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPR
QHRSRGSSGSGPDHDHAGQGTESEEQEGDSP

# Metabolic_Enzyme_66_Number_of_Residues:
450

# Metabolic_Enzyme_66_Molecular_Weight:
51836

# Metabolic_Enzyme_66_Theoretical_pI:
7.03

# Metabolic_Enzyme_66_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_66_General_Function:
Not Available

# Metabolic_Enzyme_66_Specific_Function:
May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain

# Metabolic_Enzyme_66_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_66_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_66_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_66_Signals:
None

# Metabolic_Enzyme_66_Transmembrane_Regions:
None

# Metabolic_Enzyme_66_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_66_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_66_GenBank_ID_Protein:
8439497

# Metabolic_Enzyme_66_SwissProt_ID:
PDE7B_HUMAN (Q9NP56)

# Metabolic_Enzyme_66_swissprot_Name:
Not Available

# Metabolic_Enzyme_66_Genecard_id:
PDE7B

# Metabolic_Enzyme_66_Geneatlas_id:
PDE7B

# Metabolic_Enzyme_66_hgnc_id:
HGNC:8792

# Metabolic_Enzyme_66_PDB_ID:
Not Available

# Metabolic_Enzyme_66_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_66_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_66_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_66_Gene_Sequence:
>1353 bp
ATGTCTTGTTTAATGGTTGAGAGGTGTGGCGAAATCTTGTTTGAGAACCCCGATCAGAAT
GCCAAATGTGTTTGCATGCTGGGAGATATACGACTAAGGGGTCAGACGGGGGTTCGTGCT
GAACGCCGTGGCTCCTACCCATTCATTGACTTCCGCCTACTTAACAGTACAACATACTCA
GGGGAGATTGGCACCAAGAAAAAGGTGAAAAGACTATTAAGCTTTCAAAGATACTTCCAT
GCATCAAGGCTGCTTCGTGGAATTATACCACAAGCCCCTCTGCACCTGCTGGATGAAGAC
TACCTTGGACAAGCAAGGCATATGCTCTCCAAAGTGGGAATGTGGGATTTTGACATTTTC
TTGTTTGATCGCTTGACAAATGGAAACAGCCTGGTAACACTGTTGTGCCACCTCTTCAAT
ACCCATGGACTCATTCACCATTTCAAGTTAGATATGGTGACCTTACACCGATTTTTAGTC
ATGGTTCAAGAAGATTACCACAGCCAAAACCCGTATCACAATGCTGTTCACGCAGCCGAC
GTCACCCAGGCCATGCACTGCTACCTGAAAGAGCCAAAGCTTGCCAGCTTCCTCACGCCT
CTGGACATCATGCTTGGACTGCTGGCTGCAGCAGCACACGATGTGGACCACCCAGGGGTG
AACCAGCCATTTTTGATAAAAACTAACCACCATCTTGCAAACCTATATCAGAATATGTCT
GTGCTGGAGAATCATCACTGGCGATCTACAATTGGCATGCTTCGAGAATCAAGGCTTCTT
GCTCATTTGCCAAAGGAAATGACACAGGATATTGAACAGCAGCTGGGCTCCTTGATCTTG
GCAACAGACATCAACAGGCAGAATGAATTTTTGACCAGATTGAAAGCTCACCTCCACAAT
AAAGACTTAAGACTGGAGGATGCACAGGACAGGCACTTTATGCTTCAGATCGCCTTGAAG
TGTGCTGACATTTGCAATCCTTGTAGAATCTGGGAGATGAGCAAGCAGTGGAGTGAAAGG
GTCTGTGAAGAATTCTACAGGCAAGGTGAACTTGAACAGAAATTTGAACTGGAAATCAGT
CCTCTTTGTAATCAACAGAAAGATTCCATCCCTAGTATACAAATTGGTTTCATGAGCTAC
ATCGTGGAGCCGCTCTTCCGGGAATGGGCCCATTTCACGGGTAACAGCACCCTGTCGGAG
AACATGCTGGGCCACCTCGCACACAACAAGGCCCAGTGGAAGAGCCTGTTGCCCAGGCAG
CACAGAAGCAGGGGCAGCAGTGGCAGCGGGCCTGACCACGACCACGCAGGCCAAGGGACT
GAGAGCGAGGAGCAGGAAGGCGACAGCCCCTAG

# Metabolic_Enzyme_66_GenBank_ID_Gene:
AB038040

# Metabolic_Enzyme_66_Chromosome_Location:
Not Available

# Metabolic_Enzyme_66_Locus:
Not Available

# Metabolic_Enzyme_66_SNPs:
Not Available

# Metabolic_Enzyme_66_General_References:
10814504; 10872825

# Metabolic_Enzyme_66_References:
Not Available

# Metabolic_Enzyme_67_ID:
5234

# Metabolic_Enzyme_67_Name:
5'(3')-deoxyribonucleotidase, cytosolic type

# Metabolic_Enzyme_67_Synonyms:
Cytosolic 5',3'-pyrimidine nucleotidase; Deoxy-5'-nucleotidase 1; dNT-1

# Metabolic_Enzyme_67_Gene_Name:
NT5C

# Metabolic_Enzyme_67_Protein_Sequence:
>5'3'deoxyribonucleotidase, cytosolic type
MARSVRVLVDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADK
VASVYEAPGFFLDLEPIPGALDAVREMNDLPDTQVFICTSPLLKYHHCVGEKYRWVEQHL
GPQFVERIILTRDKTVVLGDLLIDDKDTVRGQEETPSWEHILFTCCHNRHLVLPPTRRRL
LSWSDNWREILDSKRGAAQRE

# Metabolic_Enzyme_67_Number_of_Residues:
201

# Metabolic_Enzyme_67_Molecular_Weight:
23383

# Metabolic_Enzyme_67_Theoretical_pI:
6.63

# Metabolic_Enzyme_67_GO_Classification:
Not Available

# Metabolic_Enzyme_67_General_Function:
Not Available

# Metabolic_Enzyme_67_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP

# Metabolic_Enzyme_67_Pathway:
Not Available

# Metabolic_Enzyme_67_Reaction:
Not Available

# Metabolic_Enzyme_67_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_67_Signals:
None

# Metabolic_Enzyme_67_Transmembrane_Regions:
None

# Metabolic_Enzyme_67_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_67_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_67_GenBank_ID_Protein:
7524492

# Metabolic_Enzyme_67_SwissProt_ID:
NT5C_HUMAN (Q8TCD5)

# Metabolic_Enzyme_67_swissprot_Name:
Not Available

# Metabolic_Enzyme_67_Genecard_id:
NT5C

# Metabolic_Enzyme_67_Geneatlas_id:
NT5C

# Metabolic_Enzyme_67_hgnc_id:
HGNC:17144

# Metabolic_Enzyme_67_PDB_ID:
Not Available

# Metabolic_Enzyme_67_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_67_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_67_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_67_Gene_Sequence:
>606 bp
ATGGCGCGGAGCGTGCGCGTGCTGGTGGACATGGACGGCGTCCTGGCCGACTTCGAGGCC
GGCCTCCTGCGGGGCTTCCGCCGCCGCTTCCCTGAGGAGCCGCACGTGCCGCTGGAGCAA
CGCCGCGGCTTCCTGGCCCGCGAGCAGTACCGCGCCCTGCGGCCCGACCTGGCGGATAAA
GTGGCCAGTGTGTACGAAGCCCCGGGCTTTTTCCTGGACCTGGAGCCCATCCCGGGAGCC
TTGGACGCTGTGCGGGAGATGAACGACCTACCGGACACGCAGGTCTTCATCTGCACCAGC
CCCCTGCTGAAGTACCACCACTGTGTGGGTGAGAAGTACCGCTGGGTGGAGCAGCACCTG
GGGCCCCAGTTCGTAGAACGAATTATCCTGACAAGGGACAAGACGGTGGTCTTGGGGGAC
CTGCTCATTGATGACAAGGACACAGTTCGAGGCCAGGAGGAGACCCCAAGCTGGGAGCAC
ATCTTGTTCACCTGCTGCCACAATCGGCACCTGGTCCTGCCCCCGACAAGGAGACGGCTG
CTCTCCTGGAGTGACAACTGGAGGGAGATCTTAGATAGCAAGCGCGGAGCTGCGCAGCGG
GAATGA

# Metabolic_Enzyme_67_GenBank_ID_Gene:
AF154829

# Metabolic_Enzyme_67_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_67_Locus:
17q25.1

# Metabolic_Enzyme_67_SNPs:
rs4788867; rs11868451; rs3736076; rs3736075; rs12453556; rs4789144; rs11652099; rs4789143; rs11541956; rs12945569; rs3188816; rs12946860; rs1048779; rs12943507; rs34746270; rs11541955; rs12945517; rs9910084; rs34454120; rs7406461; rs4788868; rs11868212; rs1551966; rs2291027; rs2291028; rs34338273; rs3752801; rs4412997; rs4789145; rs750843; rs750844; rs899316; rs899317

# Metabolic_Enzyme_67_General_References:
10681516; 12234672

# Metabolic_Enzyme_67_References:
Not Available

# Metabolic_Enzyme_68_ID:
5885

# Metabolic_Enzyme_68_Name:
Lysyl-tRNA synthetase

# Metabolic_Enzyme_68_Synonyms:
Lysine--tRNA ligase; LysRS

# Metabolic_Enzyme_68_Gene_Name:
KARS

# Metabolic_Enzyme_68_Protein_Sequence:
>LysyltRNA synthetase
MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTT
DNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH
LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD
IIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFV
RQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAP
ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSG
MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR
KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE
GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG
LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV

# Metabolic_Enzyme_68_Number_of_Residues:
597

# Metabolic_Enzyme_68_Molecular_Weight:
68049

# Metabolic_Enzyme_68_Theoretical_pI:
6.31

# Metabolic_Enzyme_68_GO_Classification:
>>>
Function:  lysine-tRNA ligase activity
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  binding
Function:  nucleic acid binding
 ||
>>>
Process:  lysyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_68_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_68_Specific_Function:
ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)

# Metabolic_Enzyme_68_Pathway:
map00300  Lysine biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_68_Reaction:
ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)

# Metabolic_Enzyme_68_Pfam_Domain_Function:
PF00152:tRNA-synt_2;
PF01336:tRNA_anti

# Metabolic_Enzyme_68_Signals:
None

# Metabolic_Enzyme_68_Transmembrane_Regions:
None

# Metabolic_Enzyme_68_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_68_EC_Link:
EC 6.1.1.6

# Metabolic_Enzyme_68_GenBank_ID_Protein:
505108

# Metabolic_Enzyme_68_SwissProt_ID:
SYK_HUMAN (Q15046)

# Metabolic_Enzyme_68_swissprot_Name:
Not Available

# Metabolic_Enzyme_68_Genecard_id:
KARS

# Metabolic_Enzyme_68_Geneatlas_id:
KARS

# Metabolic_Enzyme_68_hgnc_id:
HGNC:6215

# Metabolic_Enzyme_68_PDB_ID:
Not Available

# Metabolic_Enzyme_68_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_68_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_68_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_68_Gene_Sequence:
>1808 bp
GGCCCTCCGGGAAGATGGCGGCCGTGCAGGCGGCCGAGGTGAAAGTGGATGGCAGCGAGC
CGAAACTGAGCAAGAATGAGCTGAAGAGACGCCTGAAAGCTGAGAAGAAAGTAGCAGAGA
AGGAGGCCAAACAGAAAGAGCTCAGTGAGAAACAGCTAAGCCAAGCCACTGCTGCTGCCA
CCAACCACACCACTGATAATGGTGTGGGTCCTGAGGAAGAGAGCGTGGACCCAAATCAAT
ACTACAAAATCCGCAGTCAAGCAATTCATCAGCTGAAGGTCAATGGGGAAGACCCATACC
CACACAAGTTCCATGTAGACATCTCACTCACTGACTTCATCCAAAAATATAGTCACCTGC
AGCCTGGGGATCACCTGACTGACATCACCTTAAAGGTGGCAGGTAGGATCCATGCCAAAA
GAGCTTCTGGGGGAAAGCTCATCTTCTATGATCTTCGAGGAGAGGGGGTGAAGTTGCAAG
TCATGGCCAATTCCAGAAATTATAAATCAGAAGAAGAATTTATTCATATTAATAACAAAC
TGCGTCGGGGAGACATAATTGGAGTTCAGGGGAATCCTGGTAAAACCAAGAAGGGTGAGC
TGAGCATCATTCCGTATGAGATCACACTGCTGTCTCCCTGTTTGCATATGTTACCTCATC
TTCACTTTGGCCTCAAAGACAAGGAAACAAGGTATCGCCAGAGATACTTGGACTTGATCC
TGAATGACTTTGTGAGGCAGAAATTTATCATCCGCTCTAAGATCATCACATATATAAGAA
GTTTCTTAGATGAGCTGGGATTCCTAGAGATTGAAACTCCCATGATGAACATCATCCCAG
GGGGAGCCGTGGCCAAGCCTTTCATCACTTATCACAACGAGCTGGACATGAACTTATATA
TGAGAATTGCTCCAGAACTCTATCATAAGATGCTTGTGGTTGGTGGCATCGACCGGGTTT
ATGAAATTGGACGCCAGTTCCGGAATGAGGGGATTGATTTGACGCACAATCCTGAGTTCA
CCACCTGTGAGTTCTACATGGCCTATGCAGACTATCACGATCTCATGGAAATCACGGAGA
AGATGGTTTCAGGGATGGTGAAGCATATTACAGGCAGTTACAAGGTCACCTACCACCCAG
ATGGCCCAGAGGGCCAAGCCTACGATGTTGACTTCACCCCACCCTTCCGGCGAATCAACA
TGGTAGAAGAGCTTGAGAAAGCCCTGGGGATGAAGCTGCCAGAAACGAACCTCTTTGAAA
CTGAAGAAACTCGCAAAATTCTTGATGATATCTGTGTGGCAAAAGCTGTTGAATGCCCTC
CACCTCGGACCACAGCCAGGCTCCTTGACAAGCTTGTTGGGGAGTTCCTGGAAGTGACTT
GCATCAATCCTACATTCATCTGTGATCACCCACAGATAATGAGCCCTTTGGCTAAATGGC
ACCGCTCTAAAGAGGGTCTGACTGAGCGCTTTGAGCTGTTTGTCATGAAGAAAGAGATAT
GCAATGCGTATACTGAGCTGAATGATCCCATGCGGCAGCGGCAGCTTTTTGAAGAACAGG
CCAAGGCCAAGGCTGCAGGTGATGATGAGGCCATGTTCATAGATGAAAACTTCTGTACTG
CCCTGGAATATGGGCTGCCCCCCACAGCTGGCTGGGGCATGGGCATTGATCGAGTCGCCA
TGTTTCTCACGGACTCCAACAACATCAAGGAAGTACTTCTGTTTCCTGCCATGAAACCCG
AAGACAAGAAGGAGAATGTAGCAACCACTGATACACTGGAAAGCACAACAGTTGGCAGTT
CTGTCTAG

# Metabolic_Enzyme_68_GenBank_ID_Gene:
D31890

# Metabolic_Enzyme_68_Chromosome_Location:
Not Available

# Metabolic_Enzyme_68_Locus:
Not Available

# Metabolic_Enzyme_68_SNPs:
Not Available

# Metabolic_Enzyme_68_General_References:
7584044; 9278442

# Metabolic_Enzyme_68_References:
Not Available

# Metabolic_Enzyme_69_ID:
5886

# Metabolic_Enzyme_69_Name:
Isoleucyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_69_Synonyms:
Isoleucine--tRNA ligase; IleRS; IRS

# Metabolic_Enzyme_69_Gene_Name:
IARS

# Metabolic_Enzyme_69_Protein_Sequence:
>IsoleucyltRNA synthetase, cytoplasmic
MSNKMLQQVPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHY
GHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEY
NNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGV
KVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAV
CVNPEMQYVKIKDVARGRLLILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFDYF
LKCKENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASG
CFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWF
VRVENMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFE
EVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGKGSLHRISEVFDCWFESGSMPYA
QVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLAS
DGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPW
YNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRL
YTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFL
TELMYQNLKVLIDPVSVQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIR
DRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGIRLRAEP
DHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDIRLMYTFDQATG
GTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAK
SEGTYLNSVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELEITLTRGSSLP
GPACAYVNLNICANGSEQGGVLLLENPKGDNRLDLLKLKSVVTSIFGVKNTELAVFHDET
EIQNQTDLLSLSGKTLCVTAGSAPSLINSSSTLLCQYINLQLLNAKPQECLMGTVGTLLL
ENPLGQNGLTHQGLLYEAAKVFGLRSRKLKLFLNETQTQEITEDIPVKTLNMKTVYVSVL
PTTADF

# Metabolic_Enzyme_69_Number_of_Residues:
1266

# Metabolic_Enzyme_69_Molecular_Weight:
144960

# Metabolic_Enzyme_69_Theoretical_pI:
6.10

# Metabolic_Enzyme_69_GO_Classification:
>>>
Function:  isoleucine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  isoleucyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_69_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_69_Specific_Function:
ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)

# Metabolic_Enzyme_69_Pathway:
map00290  Valine, leucine and isoleucine biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_69_Reaction:
ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)

# Metabolic_Enzyme_69_Pfam_Domain_Function:
PF08264:Anticodon_1;
PF00133:tRNA-synt_1

# Metabolic_Enzyme_69_Signals:
None

# Metabolic_Enzyme_69_Transmembrane_Regions:
None

# Metabolic_Enzyme_69_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_69_EC_Link:
EC 6.1.1.5

# Metabolic_Enzyme_69_GenBank_ID_Protein:
551622

# Metabolic_Enzyme_69_SwissProt_ID:
SYIC_HUMAN (P41252)

# Metabolic_Enzyme_69_swissprot_Name:
Not Available

# Metabolic_Enzyme_69_Genecard_id:
IARS

# Metabolic_Enzyme_69_Geneatlas_id:
IARS

# Metabolic_Enzyme_69_hgnc_id:
HGNC:5330

# Metabolic_Enzyme_69_PDB_ID:
Not Available

# Metabolic_Enzyme_69_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_69_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_69_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_69_Gene_Sequence:
>3801 bp
ATGAGCAACAAAATGCTTCAACAAGTTCCAGAAAACATAAATTTTCCTGCTGAAGAAGAG
AAAATCTTGGAGTTTTGGACTGAATTTAATTGTTTTCAGGAATGCTTAAAGCAATCAAAA
CATAAACCAAAATTTACCTTCTATGATGGTCCTCCTTTTGCAACTGGACTGCCTCACTAT
GGACATATACTTGCGGGTACAATTAAAGATATAGTTACAAGATATGCTCACCAGAGTGGG
TTTCATGTTGACAGAAGATTTGGATGGGATTGCCATGGCTTACCTGTGGAATATGAAATT
GATAAGACACTGGGAATCAGAGGACCAGAGGATGTGGCCAAAATGGGGATTACAGAGTAT
AACAATCAGTGCCGAGCAATTGTGATGAGATATTCTGCTGAGTGGAAGTCTACTGTTAGC
AGACTTGGCCGATGGATTGACTTTGACAATGACTATAAAACTCTGTATCCACAATTCATG
GAATCAGTCTGGTGGGTCTTCAAACAACTCTATGATAAAGGCCTTGTTTATAGAGGTGTG
AAAGTCATGCCCTTCTCTACGGCATGTAACACTCCACTTTCCAACTTCGAGTCACACCAG
AATTATAAGGATGTTCAAGATCCTTCAGTATTTGTAACTTTCCCTTTGGAAGAAGATGAA
ACTGTATCTTTAGTTGCTTGGACAACCACTCCCTGGACTCTACCTAGTAACCTTGCTGTG
TGTGTTAATCCAGAAATGCAATATGTGAAAATTAAAGATGTTGCCAGAGGACGATTACTC
ATTTTAATGGAAGCCAGATTGTCAGCCCTCTATAAATTGGAGAGTGACTATGAGATCCTT
GAAAGATTTCCTGGTGCCTATCTTAAAGGCAAGAAGTACAGGCCCCTGTTTGACTATTTC
CTGAAGTGTAAAGAGAATGGCGCTTTCACTGTGCTTGTTGACAACTATGTGAAGGAAGAA
GAAGGCACAGGGGTTGTCCACCAAGCTCCTTACTTCGGTGCTGAGGACTATCGGGTCTGT
ATGGACTTTAACATTATTCGGAAAGACTCACTCCCTGTTTGCCCTGTGGATGCTTCAGGC
TGCTTCACAACGGAGGTGACAGATTTCGCAGGACAGTATGTGAAGGATGCTGACAAAAGT
ATCATCAGGACTTTGAAGGAACAAGGCCGACTTCTGGTTGCCACCACCTTCACTCACAGC
TACCCTTTTTGCTGGAGATCAGACACTCCTCTAATTTACAAAGCAGTGCCCAGCTGGTTT
GTGCGAGTGGAGAACATGGTGGACCAGCTCCTAAGGAACAATGACCTGTGCTACTGGGTC
CCAGAGTTGGTACGAGAAAAACGATTTGGAAATTGGCTGAAAGATGCACGTGACTGGACA
ATTTCCAGAAACAGATACTGGGGCACCCCCATCCCACTGTGGGTCAGCGATGACTTTGAG
GAGGTGGTATGCATTGGGTCAGTGGCGGAACTTGAAGAACTGTCAGGAGCAAAGATCTCA
GATCTCCACAGAGAGAGTGTTGACCACCTGACCATTCCTTCACGCTGTGGGAAGGGATCC
TTGCACCGCATCTCTGAAGTGTTTGACTGTTGGTTTGAGAGTGGCAGCATGCCCTATGCT
CAGGTTCATTACCCGTTTGAAAACAAGAGGGAGTTTGAGGATGCTTTTCCTGCAGATTTC
ATTGCCGAGGGCATCGACCAAACCAGAGGATGGTTTTATACCCTGCTGGTGCTGGCCACG
GCCCTCTTTGGACAACCGCCTTTCAAGAACGTAATTGTGAATGGGCTTGTCCTGGCAAGT
GATGGCCAAAAAATGAGCAAACGGAAAAAGAATTATCCAGATCCAGTTTCCATCATCCAG
AAGTATGGTGCTGATGCCCTCAGATTATATCTGATTAACTCCCCTGTGGTGAGAGCAGAA
AACCTCCGCTTTAAAGAAGAGGGTGTGCGGGACGTCCTTAAGGATGTACTGCTCCCATGG
TACAATGCCTATCGCTTCTTAATCCAGAACGTTCTGAGGCTCCAGAAGGAGGAAGAAATA
GAATTTCTCTACAATGAGAACACGGTTAGAGAAAGCCCCAACATTACAGACCGGTGGATC
CTGTCCTTCATGCAGTCTCTCATTGGCTTCTTTGAGACTGAAATGGCAGCTTATAGGCTT
TATACTGTGGTGCCTCGCCTGGTCAAGTTTGTAGATATTCTGACCAATTGGTATGTTAGA
ATGAACCGCAGAAGATTAAAGGGTGAAAATGGGATGGAGGATTGTGTCATGGCCCTAGAA
ACCTTGTTTAGTGTTCTGCTTTCTCTTTGCAGACTTATGGCTCCCTACACACCTTTTCTC
ACTGAATTGATGTACCAGAATCTAAAGGTGCTGATTGACCCTGTTTCTGTTCAGGACAAG
GACACACTCAGCATTCACTACCTCATGCTGCCCCGTGTTCGAGAAGAATTGATTGACAAG
AAAACAGAGAGTGCAGTATCTCAGATGCAGTCTGTGATTGAACTTGGAAGAGTGATCAGA
GACCGAAAAACTATTCCCATAAAGTATCCTTTGAAAGAAATTGTGGTTATCCATCAAGAT
CCAGAAGCTCTTAAAGATATCAAGTCTTTGGAGAAGTATATCATTGAGGAACTCAATGTT
CGAAAAGTTACACTGTCTACAGATAAAAACAAGTATGGCATTCGGCTAAGGGCAGAACCA
GATCACATGGTCCTGGGGAAGCGTCTGAAGGGAGCCTTTAAGGCAGTGATGACGTCCATC
AAGCAGTTGAGCAGTGAGGAGCTGGAGCAGTTCCAGAAGACTGGGACCATTGTTGTGGAA
GGCCATGAATTGCACGATGAAGACATCCGCCTCATGTACACCTTTGATCAGGCCACAGGT
GGGACTGCGCAATTTGAAGCACACTCAGATGCTCAGGCTTTGGTCCTCTTAGATGTCACT
CCTGACCAGTCAATGGTAGATGAAGGAATGGCTCGGGAAGTCATCAATCGCATACAGAAA
CTTCGCAAAAAGTGCAATCTGGTTCCAACTGATGAAATCACAGTGTACTATAAAGCAAAG
TCTGAAGGAACATATCTGAATAGTGTTATTGAAAGCCACACAGAGTTCATATTTACCACC
ATAAAGGCTCCCTTGAAACCATATCCAGTTTCTCCATCGGATAAAGTCCTTATTCAAGAA
AAAACACAGTTGAAGGGATCTGAACTGGAAATTACACTCACCAGAGGATCTTCCCTTCCT
GGTCCTGCTTGTGCATATGTCAATCTTAACATTTGTGCAAATGGCAGTGAACAAGGTGGA
GTATTGCTCCTGGAAAATCCAAAAGGTGACAATAGGTTGGACCTTTTAAAGCTGAAGAGT
GTTGTCACTAGCATTTTTGGTGTGAAAAATACAGAGCTGGCTGTCTTCCATGATGAAACA
GAAATACAAAACCAAACTGACTTACTGAGTCTTAGTGGAAAAACACTTTGTGTGACTGCA
GGATCGGCTCCCTCTCTGATCAACAGTTCTAGTACTCTTCTTTGTCAGTATATCAACCTA
CAGCTCCTGAATGCAAAGCCACAAGAGTGTTTAATGGGGACAGTGGGCACTCTCCTGCTT
GAAAACCCACTTGGGCAGAATGGACTCACCCACCAAGGTCTTCTGTATGAAGCAGCCAAG
GTGTTTGGCCTTCGGAGCAGGAAGCTAAAGCTGTTTCTGAATGAGACCCAAACGCAGGAA
ATTACAGAAGACATCCCCGTGAAGACTTTGAATATGAAGACTGTGTATGTTTCTGTGTTA
CCAACAACAGCAGACTTCTAG

# Metabolic_Enzyme_69_GenBank_ID_Gene:
D28473

# Metabolic_Enzyme_69_Chromosome_Location:
Not Available

# Metabolic_Enzyme_69_Locus:
Not Available

# Metabolic_Enzyme_69_SNPs:
Not Available

# Metabolic_Enzyme_69_General_References:
8052601; 7721108

# Metabolic_Enzyme_69_References:
Not Available

# Metabolic_Enzyme_70_ID:
5612

# Metabolic_Enzyme_70_Name:
Glycogen phosphorylase, brain form

# Metabolic_Enzyme_70_Synonyms:
Not Available

# Metabolic_Enzyme_70_Gene_Name:
PYGB

# Metabolic_Enzyme_70_Protein_Sequence:
>Glycogen phosphorylase, brain form
MAKPLTDSEKRKQISVRGLAGLGDVAEVRKSFNRHLHFTLVKDRNVATPRDYFFALAHTV
RDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTMVNLGLQNACDEAIYQLGLDL
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKIVNGWQVEEA
DDWLRYGNPWEKARPEYMLPVHFYGRVEHTPDGVKWLDTQVVLAMPYDTPVPGYKNNTVN
TMRLWSAKAPNDFKLQDFNVGDYIEAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTCFETFPDKVAIQLNDTHPALSIPELMRILVDVEKV
DWDKAWEITKKTCAYTNHTVLPEALERWPVSMFEKLLPRHLEIIYAINQRHLDHVAALFP
GDVDRLRRMSVIEEGDCKRINMAHLCVIGSHAVNGVARIHSEIVKQSVFKDFYELEPEKF
QNKTNGITPRRWLLLCNPGLADTIVEKIGEEFLTDLSQLKKLLPLVSDEVFIRDVAKVKQ
ENKLKFSAFLEKEYKVKINPSSMFDVHVKRIHEYKRQLLNCLHVVTLYNRIKRDPAKAFV
PRTVMIGGKAAPGYHMAKLIIKLVTSIGDVVNHDPVVGDRLKVIFLENYRVSLAEKVIPA
ADLSQQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGAENLFIFGLRVEDVE
ALDRKGYNAREYYDHLPELKQAVDQISSGFFSPKEPDCFKDIVNMLMHHDRFKVFADYEA
YMQCQAQVDQLYRNPKEWTKKVIRNIACSGKFSSDRTITEYAREIWGVEPSDLQIPPPNI
PRD

# Metabolic_Enzyme_70_Number_of_Residues:
843

# Metabolic_Enzyme_70_Molecular_Weight:
96697

# Metabolic_Enzyme_70_Theoretical_pI:
6.85

# Metabolic_Enzyme_70_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
Function:  phosphorylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_70_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_70_Specific_Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

# Metabolic_Enzyme_70_Pathway:
map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_70_Reaction:
(1,4-alpha-D-glucosyl)n + phosphate = (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate

# Metabolic_Enzyme_70_Pfam_Domain_Function:
PF00343:Phosphorylase

# Metabolic_Enzyme_70_Signals:
None

# Metabolic_Enzyme_70_Transmembrane_Regions:
None

# Metabolic_Enzyme_70_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_70_EC_Link:
EC 2.4.1.1

# Metabolic_Enzyme_70_GenBank_ID_Protein:
307200

# Metabolic_Enzyme_70_SwissProt_ID:
PYGB_HUMAN (P11216)

# Metabolic_Enzyme_70_swissprot_Name:
Not Available

# Metabolic_Enzyme_70_Genecard_id:
PYGB

# Metabolic_Enzyme_70_Geneatlas_id:
PYGB

# Metabolic_Enzyme_70_hgnc_id:
HGNC:9723

# Metabolic_Enzyme_70_PDB_ID:
Not Available

# Metabolic_Enzyme_70_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_70_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_70_Subcellular_Location:
Not Available

# Metabolic_Enzyme_70_Gene_Sequence:
>2592 bp
ATGGGCGAACCGCTGACGGACAGCGAGAAGCGGAAGCAGATCAGCGTGCGCGGCCTGGCG
GGGCTAGGCGACGTGGCCGAGGTGCGGAAGAGCTTCAACCGGCACTTGCACTTCACGCTG
GTCAAGGACCGCAATGTGGCCACGCCCCGCGACTACTTCTTCGCGCTGGCGCACACGGTG
CGCGACCACCTCGTGGGCCGCTGGATCCGCACGCAGCAGCACTACTACGAGCGCGACCCC
AAGCGAATTTATTATCTTTCCCTGGAATTCTACATGGGTCGCACGCTGCAGAACACGATG
GTGAACCTGGGCCTTCAGAATGCCTGCGATGAAGCCATCTATCAGTTGGGGTTAGACTTG
GAGGAACTCGAGGAGATAGAAGAAGATGCTGGCCTTGGGAATGGAGGCCTGGGGAGGCTG
GCAGCGTGTTTCCTTGACTCAATGGCTACCTTGGGCCTGGCAGCATACGGCTATGGAATC
CGCTATGAATTTGGGATTTTTAACCAGAAGATTGTCAATGGCTGGCAGGTAGAGGAGGCC
GATGACTGGCTGCGCTACGGCAACCCCTGGGAGAAAGCGCGGCCTGAGTATATGCTTCCC
GTGCACTTCTACGGACGCGTGGAGCACACCCCCGACGGCGTGAAGTGGCTGGACACACAG
GTGGTGCTGGCCATGCCCTACGACACCCCAGTGCCCGGCTACAAGAACAACACCGTCAAC
ACCATGCGGCTGTGGTCCGCAAGGGCTCCCAACGACTTCAAGCTGCAGGACTTCAACGTG
GGAGACTACATCGAGGCGGTCCTGGACCGGAACTTGGCTGAGAACATCTCCAGGGTCCTG
TATCCAAATGATAACTTCTTTGAGGGGAAGGAGCTGCGGCTGAAGCAGGAGTACTTCGTG
GTGGGCGCCACGCTCCAGGACATCATCCGCCGCTTCAAGTCGTCCAAGTTCGGCTGCCGG
GACCCTGTGAGAACCTGTTTCGAGACGTTCCCAGACAAGGTGGCCATCCAGCTGAACGAC
ACCCACCCCGCCCTCTCCATCCCTGAGCTCATGCGGATCCTGGTGGACGTGGAGAAGGTG
GACTGGGACAAGGCCTGGGAAATCACGAAGAAGACCTGTGCATACACCAACCACACTGTG
CTGCCTGAGGCCTTGGAGCGCTGGCCCGTGTCCATGTTTGAGAAGCTGCTGCCGCGGCAC
CTGGAGATAATCTATGCCATCAACCAGCGGCACCTGGACCACGTGGCCGCGCTGTTTCCC
GGCGATGTGGACCGCCTGCGCAGGATGTCTGTGATCGAGGAGGGGGACTGCAAGCGGATC
AACATGGCCCACCTGTGTGTGATTGGGTCCCATGCTGTCAATGGTGTGGCGAGGATCCAC
TCGGAGATCGTGAAACAGTCGGTCTTTAAGGATTTTTATGAACTGGAGCCAGAGAAGTTC
CAGAATAAGACCAATGGCATCACCCCCCGCCGGTGGCTGCTGCTGTGCAACCCGGGGCTG
GCCGATACCATCGTGGAGAAAATTGGGGAGGAGTTCCTGACTGACCTGAGCCAGCTGAAG
AAGCTGCTGCCGCTGGTCAGTGACGAGGTGTTCATCAGGGACGTGGCCAAGGTCAAACAG
GAGAACAAGCTCAAGTTCTCGGCCTTCCTGGAGAAGGAGTACAAGGTGAAGATCAACCCC
TCCTCCATGTTCGATGTGCATGTGAAGAGGATCCACGAGTACAAGCGGCAGCTGCTCAAC
TGCCTGCACGTCGTCACCCTGTACAATCGAATCAAGAGAGACCCGGCCAAGGCTTTTGTG
CCCAGGACTGTTATGATTGGGGGCAAGGCAGCGCCCGGTTACCACATGGCCAAGCTGATC
ATCAAGTTGGTCACCTCCATCGGCGACGTCGTCAATCATGACCCAGTTGTGGGTGACAGG
TTGAAAGTGATCTTCCTGGAGAACTACCGTGTGTCCTTGGCTGAGAAAGTGATCCCGGCC
GCTGATCTGTCGCAGCAGATCTCCACTGCAGGCACCGAGGCCTCAGGCACAGGCAACATG
AAGTTCATGCTCAACGGGGCCCTCACCATCGGCACCATGGACGGCGCCAACGTGGAGATG
GCCGAGGAGGCCGGGGCCGAGAACCTCTTCATCTTCGGCCTGCGGGTGGAGGATGTCGAG
GCCTTGGACCGGAAAGGGTACAATGCCAGGGAGTACTACGACCACCTGCCCGAGCTGAAG
CAGGCCGTGGACCAGATCAGCAGTGGCTTTTTTTCTCCCAAGGAGCCAGACTGCTTCAAG
GACATCGTGAACATGCTGATGCACCATGACAGGTTCAAGGTGTTTGCAGACTATGAAGCC
TACATGCAGTGCCAGGCACAGGTGGACCAGCTGTACCGGAACCCCAAGGAGTGGACCAAG
AAGGTCATCAGGAACATCGCCTGCTCGGGCAAGTTCTCCAGTGACCGGACCATCACGGAG
TATGCACGGGAGATCTGGGGTGTGGAGCCCTCCGACCTGCAGCTTCAGCACCTGCCCCAC
CCAGAGTGGGAGTCAGGTGGAGCCACCTGCTGGGCTCCCCCAGAACTTTGCACACATCTT
GCTATGTATTAG

# Metabolic_Enzyme_70_GenBank_ID_Gene:
J03544

# Metabolic_Enzyme_70_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_70_Locus:
20p11.2-p11.1

# Metabolic_Enzyme_70_SNPs:
rs2227891; rs2228976; rs2227892; rs2227890; rs2228977; rs16987612; rs6515626; rs6050486; rs2261720; rs2257808; rs2261109; rs910996; rs2424698; rs6050510; rs2261785; rs2424699; rs2257233; rs2261794; rs2257705; rs2261115; rs2261698; rs2257809; rs2281562; rs2257464; rs2261784; rs2260997; rs2474772; rs2257461; rs2424700; rs2261795; rs7269045; rs6050512; rs2261790; rs2261753; rs2261747; rs2257712; rs2474769; rs2257370; rs6050511; rs6037075; rs1555329; rs2258052; rs6115107; rs2281558; rs3787078; rs2258053; rs2145125; rs2258201; rs6107024; rs11697384; rs6115109; rs2257991; rs8118763; rs753009; rs910997; rs1555331; rs6107023; rs6115118; rs2258563; rs6050509; rs6050502; rs6037070; rs4813555; rs7273544; rs6115115; rs2257432; rs6115101; rs2281559; rs8184820; rs2474767; rs3787082; rs2424704; rs8116542; rs6050487; rs2424701; rs3787081; rs6138555; rs3787080; rs1555330; rs8124539; rs8114792; rs2500411; rs2258135; rs2474777; rs6115117; rs2257982; rs8120601; rs6115114; rs6107017; rs2474763; rs12624460; rs2257988; rs11087508; rs2474770; rs6037071; rs13038092; rs2500410; rs6050513; rs11087511; rs6132824; rs2474773; rs2424703; rs6050501; rs2387734; rs11699953; rs6076328; rs6050488; rs12624693; rs2145126; rs12625357; rs12625045; rs2474766; rs11697736; rs6107021; rs6132825; rs6115121; rs2500413; rs7274919; rs6037069; rs6115106; rs3002702; rs2474762; rs2257649; rs8115188; rs2180597; rs6115116; rs6050515; rs4815398; rs2257985; rs12624472; rs8125980; rs6107022; rs6107019; rs2258066; rs2258617; rs2273473; rs6138553; rs7274104; rs6132822; rs11549036; rs6037077; rs6115125; rs6115124; rs35481467; rs6050484; rs35073849; rs2228978; rs6115120; rs35669741; rs35189278; rs6083789; rs2474764; rs11474310; rs34233544; rs4619688; rs34170256; rs11483996; rs34871259; rs12625447; rs7272247; rs11472555; rs6083794; rs6115113; rs6115108; rs8125437; rs6050485; rs11472504; rs11471241; rs35760653; rs2254046; rs3838000; rs6050503; rs7274130; rs11473890; rs6050520; rs6083790; rs6050507; rs2180596; rs6115102; rs10582106; rs6115129; rs6037079; rs7353137; rs11466827; rs6050493; rs2474774; rs6050491; rs6107018; rs35358504; rs11468635; rs11468776; rs13043218; rs34067778; rs34827380; rs11475816; rs41282330; rs6138556; rs5841050; rs34496209; rs6050498; rs13043643; rs34360139; rs35375864; rs13044624; rs6107020; rs6138551; rs11699652; rs2474776; rs6115123; rs2474768; rs6050508; rs11312793; rs35716293; rs6115104; rs35058859; rs36105797; rs6050494; rs13433150; rs11470476; rs34346429; rs6050492; rs11471520; rs6115128; rs6115103; rs12106151; rs2983489; rs6050504; rs11468520; rs6083788; rs41282328; rs6050490; rs11087510; rs28770021; rs35286896; rs4364079; rs6050521; rs11475085; rs6138558; rs6037068; rs7352961; rs11480235; rs33973694; rs7269584; rs6115130; rs2983490; rs11350552; rs6115110; rs5841051; rs35988788; rs35243193; rs2281561; rs6050495; rs6138552; rs6076330; rs35609563; rs12626048; rs7363911; rs6083793; rs6115122; rs34299454; rs6115105; rs34646441; rs2474775; rs35264724; rs33964550; rs6050505; rs12625048; rs2474771; rs11477346; rs2500426; rs6050522; rs6050519; rs34336965; rs6138559; rs8114789; rs36117882; rs11470854; rs35760227; rs3841696; rs5841052; rs13433144; rs2281560; rs6050523; rs1118963; rs33999482; rs35370770; rs34672197; rs13038488; rs35258354; rs34316192; rs34427422; rs35256912; rs11479739; rs6037073; rs13043662; rs3787079; rs34204571; rs6083791; rs6115111; rs11908154; rs34776023; rs7272959; rs1077889; rs28881233; rs6083792; rs11480711; rs6138554; rs13037005; rs2474765; rs35263526; rs6050483; rs34955390; rs1046073; rs10966; rs1130694; rs11905042; rs2258719; rs2258769; rs2259873; rs2260197; rs2261796; rs2474779; rs2474780; rs6050471; rs6050473; rs6050475; rs6050476; rs6050477; rs6050481; rs6107016; rs6107027; rs6115098; rs6115100; rs7019; rs7344105; rs746748; rs8119343; rs9927

# Metabolic_Enzyme_70_General_References:
3346228; 2615594; 11780052; 12665801

# Metabolic_Enzyme_70_References:
Not Available

# Metabolic_Enzyme_71_ID:
5887

# Metabolic_Enzyme_71_Name:
Bis(5'-adenosyl)-triphosphatase

# Metabolic_Enzyme_71_Synonyms:
Diadenosine 5',5'''- P1,P3-triphosphate hydrolase; Dinucleosidetriphosphatase; AP3A hydrolase; AP3AASE; Fragile histidine triad protein

# Metabolic_Enzyme_71_Gene_Name:
FHIT

# Metabolic_Enzyme_71_Protein_Sequence:
>Bis5'adenosyltriphosphatase
MSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQ
TTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDFHRNDSIYEELQKH
DKEDFPASWRSEEEMAAEAAALRVYFQ

# Metabolic_Enzyme_71_Number_of_Residues:
147

# Metabolic_Enzyme_71_Molecular_Weight:
16858

# Metabolic_Enzyme_71_Theoretical_pI:
7.09

# Metabolic_Enzyme_71_GO_Classification:
Not Available

# Metabolic_Enzyme_71_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_71_Specific_Function:
Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues

# Metabolic_Enzyme_71_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_71_Reaction:
P1-P3-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP

# Metabolic_Enzyme_71_Pfam_Domain_Function:
PF01230:HIT

# Metabolic_Enzyme_71_Signals:
1-24

# Metabolic_Enzyme_71_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_71_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_71_EC_Link:
EC 3.6.1.29

# Metabolic_Enzyme_71_GenBank_ID_Protein:
1203836

# Metabolic_Enzyme_71_SwissProt_ID:
FHIT_HUMAN (P49789)

# Metabolic_Enzyme_71_swissprot_Name:
Not Available

# Metabolic_Enzyme_71_Genecard_id:
FHIT

# Metabolic_Enzyme_71_Geneatlas_id:
FHIT

# Metabolic_Enzyme_71_hgnc_id:
HGNC:3701

# Metabolic_Enzyme_71_PDB_ID:
1FHI

# Metabolic_Enzyme_71_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_71_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_71_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_71_Gene_Sequence:
>444 bp
ATGTCGTTCAGATTTGGCCAACATCTCATCAAGCCCTCTGTAGTGTTTCTCAAAACAGAA
CTGTCCTTCGCTCTTGTGAATAGGAAACCTGTGGTACCAGGACATGTCCTTGTGTGCCCG
CTGCGGCCAGTGGAGCGCTTCCATGACCTGCGTCCTGATGAAGTGGCCGATTTGTTTCAG
ACGACCCAGAGAGTCGGGACAGTGGTGGAAAAACATTTCCATGGGACCTCTCTCACCTTT
TCCATGCAGGATGGCCCCGAAGCCGGACAGACTGTGAAGCACGTTCACGTCCATGTTCTT
CCCAGGAAGGCTGGAGACTTTCACAGGAATGACAGCATCTATGAGGAGCTCCAGAAACAT
GACAAGGAGGACTTTCCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCA
GCTCTGCGGGTCTACTTTCAGTGA

# Metabolic_Enzyme_71_GenBank_ID_Gene:
U46922

# Metabolic_Enzyme_71_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_71_Locus:
3p14.2

# Metabolic_Enzyme_71_SNPs:
rs1385816; rs17255497; rs2077774; rs1569346; rs1735457; rs1385717; rs1550343; rs1009947; rs2682966; rs1716745; rs2205343; rs2118809; rs1562525; rs1735444; rs1001788; rs1447918; rs1716718; rs812965; rs1374916; rs1623091; rs2856071; rs1347852; rs967318; rs1735468; rs2856042; rs2736736; rs741891; rs1735469; rs2083264; rs2205352; rs2256806; rs1439006; rs1029277; rs2682931; rs939497; rs1439004; rs2365057; rs1371095; rs241697; rs1916801; rs180992; rs1524020; rs1735471; rs1447924; rs986687; rs721207; rs2682956; rs2594257; rs2736737; rs2886377; rs2044613; rs1880218; rs1735443; rs1898748; rs926139; rs2594135; rs967319; rs180994; rs1447926; rs2856036; rs1735460; rs1716748; rs2856072; rs2142294; rs2856056; rs1470035; rs762693; rs2856025; rs2856038; rs1966136; rs1839075; rs717228; rs2205353; rs2064012; rs2594159; rs939496; rs2885865; rs1447925; rs717762; rs2365045; rs760314; rs2682968; rs10866041; rs6782531; rs9876185; rs9843949; rs181003; rs7642017; rs4515043; rs2856034; rs6804627; rs241663; rs4679483; rs6776499; rs7649991; rs7653382; rs6445197; rs1562519; rs7648833; rs7651468; rs4688324; rs9841152; rs2682970; rs6787292; rs2856044; rs4974227; rs6446140; rs1350636; rs10510851; rs6803394; rs9840822; rs6786213; rs13098348; rs9882477; rs1554599; rs6446170; rs1439008; rs2049799; rs9857606; rs9821406; rs1562523; rs9879376; rs11130815; rs11130802; rs2856030; rs7641604; rs9878766; rs9754605; rs11917930; rs6783059; rs181349; rs11130807; rs9846267; rs2594145; rs7642143; rs7609861; rs2142296; rs9826128; rs1980309; rs6807877; rs2044611; rs2682954; rs6446179; rs9844741; rs9877396; rs4974255; rs6792544; rs11926787; rs11925038; rs9862895; rs1716753; rs4974235; rs11130777; rs6765136; rs2205351; rs2205360; rs928945; rs9311778; rs13070504; rs4309721; rs1868220; rs1972855; rs2365491; rs13320646; rs6765028; rs1007220; rs1371091; rs9851485; rs4974249; rs11130821; rs1821943; rs9836987; rs6773741; rs9849262; rs6769544; rs12492010; rs9828898; rs7610484; rs9311773; rs12107532; rs11130775; rs1597101; rs2682963; rs4688135; rs9811973; rs9832173; rs10451993; rs6789015; rs6797329; rs3937353; rs4688142; rs2100152; rs9827976; rs12635622; rs10510854; rs9852628; rs7649096; rs7616887; rs9850777; rs7653771; rs6788585; rs11130794; rs6791911; rs1447930; rs6774839; rs9879276; rs12107530; rs10866044; rs2736742; rs6763300; rs2856027; rs11130812; rs7645482; rs180995; rs11706821; rs2178808; rs9826800; rs2682967; rs6445192; rs1447921; rs1916800; rs1627302; rs7638403; rs9311790; rs6446149; rs9819076; rs1562524; rs11720214; rs7613542; rs6794160; rs6791496; rs11130813; rs7636370; rs2594123; rs7426804; rs7647122; rs2682971; rs9827069; rs10510852; rs2142041; rs1868225; rs6446175; rs13323296; rs7632868; rs11915345; rs2363667; rs11130804; rs9811235; rs6774194; rs6762641; rs6445194; rs11130816; rs9844497; rs7618351; rs1347853; rs6779985; rs1898750; rs1916802; rs6793385; rs5016304; rs6807748; rs9866844; rs4974236; rs4132221; rs6809125; rs7640756; rs9311768; rs7641177; rs7615191; rs9311777; rs9850125; rs1447919; rs2856055; rs2594130; rs9815092; rs11710207; rs940337; rs12054041; rs2121845; rs4129352; rs6773775; rs4679482; rs9832938; rs9842587; rs7629382; rs780375; rs7638130; rs9811056; rs9875844; rs9884072; rs7631246; rs9849709; rs7618762; rs7644694; rs9816087; rs9845743; rs4974256; rs9814846; rs7636357; rs1735461; rs6446157; rs9879362; rs6445196; rs2205350; rs9857754; rs2205349; rs3920477; rs6775612; rs9311775; rs6808414; rs1122667; rs939495; rs13100357; rs9823902; rs9311795; rs9863683; rs1900669; rs7371876; rs9814327; rs1978865; rs1447923; rs7616675; rs9875365; rs9754838; rs2594144; rs724025; rs1866433; rs9879848; rs9820332; rs9859201; rs1716734; rs9819588; rs11130776; rs2218088; rs9868891; rs11924304; rs2734368; rs4688310; rs9833215; rs7650937; rs6783115; rs10866046; rs9823013; rs6765371; rs241672; rs1623349; rs9861551; rs9870560; rs6777567; rs7619721; rs1716749; rs11926400; rs9820155; rs1349031; rs12107509; rs7640496; rs1716752; rs6772782; rs11916720; rs2363669; rs2734369; rs7644380; rs6772346; rs11130803; rs7617530; rs6775705; rs7636178; rs7652163; rs9311774; rs11130822; rs1821942; rs9853124; rs181001; rs2736741; rs10866045; rs6446173; rs180998; rs7617424; rs6445198; rs9820971; rs1980310; rs12107512; rs6446174; rs4974248; rs10510855; rs6446143; rs2165041; rs2255772; rs717291; rs11130782; rs1868226; rs1965143; rs12638248; rs9990051; rs9875228; rs6445191; rs2226972; rs1898752; rs9815151; rs6771383; rs7630291; rs1880213; rs9311779; rs12629814; rs6787897; rs7640419; rs2734365; rs2594134; rs1403968; rs6805412; rs7624678; rs12107986; rs2121858; rs4974239; rs7621722; rs11130820; rs12489758; rs6777650; rs10510849; rs6805796; rs6791644; rs2886257; rs7651235; rs9861707; rs6446150; rs2736745; rs6785030; rs6767314; rs9845774; rs4974241; rs2040378; rs2736740; rs2223084; rs6802326; rs1439001; rs1029276; rs1447927; rs7619248; rs11130800; rs12633258; rs9839019; rs9821525; rs9990356; rs12632664; rs7611169; rs9813580; rs9871451; rs7646223; rs11919495; rs17063911; rs7609667; rs2682930; rs9855931; rs9852553; rs17624325; rs1447914; rs11922368; rs17687956; rs2682979; rs7627621; rs11130785; rs12494672; rs9860076; rs12491463; rs9831324; rs4679481; rs9871598; rs7650309; rs2365059; rs9880554; rs1716705; rs1584341; rs1898749; rs17670088; rs6766713; rs6781958; rs9811304; rs11924124; rs12715562; rs4296587; rs2682984; rs1530093; rs2736738; rs9818351; rs2301156; rs17063986; rs10049287; rs7372683; rs4688293; rs12496064; rs2262951; rs1969420; rs12487370; rs10510858; rs2251707; rs9833533; rs9838172; rs9826649; rs735667; rs1947158; rs6446159; rs2736754; rs6805296; rs11716874; rs2247359; rs6777895; rs2736756; rs2594233; rs9832404; rs17681785; rs9819985; rs6797228; rs2594165; rs17063904; rs2006807; rs9880496; rs17683604; rs7627137; rs2734370; rs7616671; rs9832387; rs11712250; rs6785095; rs9819311; rs17064252; rs1735440; rs2594125; rs2856032; rs10049007; rs1123706; rs11925380; rs12489627; rs6792606; rs9840107; rs2856057; rs12631370; rs11711523; rs2682960; rs7631101; rs6802718; rs13087102; rs11130791; rs13098466; rs1735478; rs7432066; rs7610478; rs2856017; rs12630435; rs6782382; rs4688295; rs721779; rs9875504; rs1735462; rs2364295; rs1735475; rs9850400; rs2205345; rs6446165; rs4974229; rs6772819; rs6790615; rs11709041; rs1716747; rs9865619; rs11921290; rs17064029; rs9854653; rs4974230; rs4974254; rs10510856; rs2178809; rs11130798; rs4688352; rs11130817; rs2365052; rs9862715; rs2856068; rs11920498; rs7639157; rs6414609; rs9842471; rs181002; rs9856186; rs1716724; rs17064329; rs2736744; rs9845331; rs7650786; rs6446164; rs2252742; rs2594163; rs12492901; rs1839069; rs11130809; rs13317838; rs9857057; rs6792962; rs2736734; rs11917807; rs6794439; rs9816911; rs1554601; rs2594129; rs13060659; rs7650320; rs6793580; rs7652906; rs9836639; rs2682946; rs13093744; rs6446172; rs17679400; rs9819092; rs760315; rs11923137; rs9860669; rs12637393; rs2365054; rs6445190; rs2856037; rs2105829; rs10049454; rs9311769; rs11707666; rs6762099; rs9850904; rs1716737; rs11709918; rs7637553; rs1584337; rs6765479; rs12492395; rs6799902; rs17627738; rs1371093; rs11922845; rs9311792; rs6414610; rs1880212; rs2736755; rs9876579; rs7643970; rs2251704; rs17063920; rs6801782; rs2594158; rs7610999; rs17695525; rs11716931; rs11130796; rs6805904; rs9880898; rs2856021; rs17669863; rs6768933; rs4260356; rs11711479; rs2734366; rs9840473; rs17687542; rs7646749; rs9827045; rs6806667; rs1562520; rs6446136; rs6798786; rs13096204; rs9878801; rs2594161; rs10222378; rs17064630; rs6784732; rs17064395; rs10222544; rs9834435; rs1629179; rs6787313; rs2121857; rs11923145; rs12107589; rs10866043; rs1980311; rs11915333; rs2156974; rs9839778; rs6772523; rs9816492; rs11920478; rs9827591; rs11130833; rs1880214; rs6783370; rs6801658; rs9837947; rs7633853; rs12493259; rs7630746; rs2594141; rs10510864; rs13099522; rs9859690; rs2682951; rs1716722; rs11711708; rs4688350; rs1839070; rs7612949; rs12715565; rs6445195; rs9828177; rs12498118; rs17684830; rs12496007; rs2594157; rs9311771; rs7611737; rs1562522; rs6782022; rs7432943; rs6806415; rs9878020; rs9845200; rs11919041; rs1716714; rs9845837; rs6792330; rs241682; rs12487188; rs1716739; rs17031633; rs9864191; rs17669257; rs2121844; rs9846073; rs2044612; rs9871875; rs7429680; rs753662; rs6799513; rs17064093; rs2365485; rs6786392; rs6779150; rs2165040; rs7622298; rs753661; rs12715561; rs4574237; rs6790097; rs9875984; rs11130834; rs2594122; rs7627303; rs12493219; rs17064607; rs1839068; rs6446133; rs9849413; rs9827764; rs2205342; rs1595603; rs7642546; rs17632419; rs6446160; rs6762126; rs9878477; rs6786508; rs6789174; rs1839065; rs17628405; rs6809101; rs7640076; rs11130795; rs9843237; rs1735439; rs6795855; rs2226971; rs17637930; rs7639167; rs1716720; rs2736748; rs11712505; rs9856262; rs9839082; rs6801370; rs6809666; rs1980308; rs9311788; rs13065371; rs12638023; rs2886261; rs9816826; rs2594265; rs940338; rs10510848; rs7646887; rs9311772; rs17680010; rs7638831; rs13095530; rs17063507; rs9827340; rs11130811; rs9850713; rs12489122; rs17064094; rs7631974; rs6793095; rs6809331; rs7612453; rs13315187; rs9758127; rs1716732; rs9311781; rs17064337; rs13093215; rs12053964; rs11707984; rs9883165; rs11130818; rs2856018; rs2205344; rs7636682; rs11713112; rs1447959; rs4679480; rs7644525; rs12107501; rs13323679; rs6765664; rs6785709; rs2594132; rs10510857; rs171351; rs1584336; rs9860195; rs2856041; rs9864812; rs9841468; rs12487847; rs6446135; rs7653468; rs13093016; rs17063870; rs9820046; rs7645257; rs6772719; rs17063899; rs11921459; rs9847604; rs12498001; rs2365051; rs1439002; rs9311786; rs11707813; rs151737; rs2736743; rs6446178; rs9876711; rs6791680; rs2594164; rs9818734; rs9878248; rs9827254; rs1716717; rs11918370; rs12487927; rs17063778; rs4535219; rs11130825; rs2594137; rs9882068; rs11130789; rs9812158; rs1540263; rs6786595; rs7634868; rs2594166; rs6804478; rs13070093; rs1447928; rs17064185; rs7642109; rs12053817; rs6785140; rs2736749; rs9862122; rs9866904; rs180987; rs180999; rs10510859; rs2736732; rs11130790; rs9311770; rs9823201; rs9860640; rs6775908; rs6446171; rs9834766; rs7634073; rs12637792; rs9879191; rs1625810; rs7617867; rs9866093; rs17063532; rs2594152; rs13324938; rs2594139; rs2734350; rs6780515; rs9845479; rs2064011; rs11923043; rs9881065; rs4688351; rs6779250; rs1439005; rs2003793; rs2365058; rs17634797; rs2736733; rs13094165; rs9849474; rs9831680; rs2156973; rs12632698; rs11130793; rs241671; rs2856067; rs9861400; rs7653719; rs12152491; rs17670198; rs9853818; rs2736758; rs12633494; rs2365389; rs7625928; rs9826570; rs720000; rs11925426; rs12185984; rs7615687; rs9843007; rs9311776; rs241669; rs1823239; rs2682944; rs7651431; rs9834182; rs7633325; rs2165044; rs9869954; rs6791272; rs10048949; rs11130772; rs9811478; rs2682945; rs1716721; rs11715589; rs2682962; rs11926529; rs17064561; rs6788110; rs4688332; rs13063937; rs4974250; rs1716744; rs17064527; rs9861713; rs6793737; rs7631028; rs9860681; rs9825823; rs11712757; rs4315681; rs4974251; rs11705999; rs17064099; rs9837996; rs1530092; rs12492742; rs6768425; rs13088130; rs11929245; rs2856029; rs9830298; rs1665; rs1627398; rs7640909; rs9827312; rs10049452; rs9875651; rs12491786; rs12638171; rs11927024; rs7624552; rs17063990; rs13319380; rs1562521; rs9808931; rs17680697; rs1447917; rs6803624; rs11914567; rs10510853; rs2886260; rs13322666; rs11130780; rs9856859; rs11130805; rs7432088; rs2594254; rs9876863; rs2856045; rs17064259; rs9311791; rs17063517; rs7650123; rs1868223; rs1866434; rs11923899; rs10866042; rs9851616; rs6772800; rs9877318; rs1716709; rs2734367; rs9870497; rs12631593; rs11717799; rs7645898; rs10510850; rs9917755; rs9829212; rs9876876; rs12497257; rs12486280; rs9836897; rs180993; rs6788545; rs2205359; rs7646851; rs6446169; rs9851572; rs1158425; rs1524021; rs17064285; rs2363683; rs9819641; rs2118811; rs11711938; rs7626688; rs17624475; rs4974234; rs6446183; rs2682977; rs12495226; rs11922889; rs9842407; rs17064628; rs1618561; rs11130835; rs2856059; rs9857131; rs9859004; rs17064433; rs6799836; rs13068378; rs17668477; rs17063959; rs2028279; rs7645096; rs17063923; rs11929123; rs6768495; rs7645256; rs2855998; rs7651494; rs2594143; rs13322787; rs2856077; rs6788916; rs9311780; rs9831013; rs13074044; rs9942059; rs6783304; rs4571197; rs17686365; rs1595602; rs4688311; rs1716738; rs9867960; rs9814044; rs11130810; rs1374918; rs9825739; rs9829855; rs17063700; rs17064324; rs9820462; rs9849678; rs7652525; rs12491168; rs7618423; rs9840160; rs2856005; rs9880152; rs12492140; rs13079016; rs241683; rs7627681; rs939498; rs7645767; rs17064253; rs6793104; rs9809234; rs7637834; rs7630972; rs12629959; rs2003794; rs13078149; rs9848948; rs7637810; rs10510860; rs9829886; rs9847651; rs9821316; rs6776937; rs9871579; rs17632681; rs9839793; rs9872457; rs1735466; rs13323037; rs6798559; rs2367086; rs9840901; rs9682902; rs6762120; rs9850978; rs11710387; rs9311796; rs1839066; rs11923434; rs7618714; rs9839509; rs780374; rs7642882; rs1447929; rs12493843; rs11130819; rs6772308; rs11130826; rs7610879; rs6793486; rs9842893; rs13320670; rs9837423; rs7434129; rs7621451; rs17064381; rs9849061; rs9838335; rs12492551; rs9847761; rs11718033; rs9868814; rs13326569; rs11923559; rs1916799; rs12495145; rs9854694; rs6789900; rs9843597; rs9816751; rs1716733; rs4405865; rs6772908; rs715382; rs7626618; rs12490370; rs35143592; rs4688348; rs9799246; rs1716735; rs17063922; rs2736747; rs17635382; rs2213215; rs9868716; rs17063578; rs9846375; rs4974240; rs6797098; rs741892; rs6770423; rs11714760; rs2736731; rs1439003; rs7643144; rs9311794; rs13075102; rs17063883; rs13319645; rs2594167; rs9865739; rs9809371; rs12494967; rs7642517; rs12374031; rs17064507; rs2682949; rs242187; rs7641486; rs17064320; rs9864918; rs9828175; rs1473644; rs13088635; rs17031618; rs1898751; rs241674; rs6787511; rs4402933; rs2156969; rs7631695; rs12496920; rs11130783; rs12492849; rs13059280; rs17064615; rs9841262; rs7643503; rs12491629; rs13099398; rs17624499; rs11719227; rs1882897; rs7612963; rs17063617; rs6762122; rs2205348; rs9866066; rs2856039; rs9843759; rs2594138; rs9817302; rs6791660; rs6796003; rs9829652; rs9858680; rs241664; rs13314067; rs6809918; rs9848914; rs9879770; rs11706094; rs715381; rs4679549; rs2682981; rs11714398; rs17064510; rs1900668; rs17064090; rs7374200; rs7621672; rs12330767; rs7372419; rs9882800; rs1735445; rs9867019; rs6805291; rs13076604; rs17685850; rs9881274; rs2365050; rs7641121; rs17064336; rs9881340; rs12491965; rs9820533; rs2594147; rs12497528; rs9868743; rs2166814; rs2040377; rs241670; rs9831193; rs2594253; rs9814616; rs717292; rs9857165; rs9832941; rs2121859; rs1447922; rs17063813; rs9816956; rs9834262; rs2250114; rs9864149; rs9827546; rs1374919; rs2886256; rs7626576; rs4393862; rs2736750; rs4402886; rs6762597; rs1735449; rs2856076; rs2365042; rs17686275; rs1735453; rs9816210; rs13094263; rs9826131; rs9868863; rs13087545; rs12632702; rs2682969; rs4453834; rs17686079; rs17624439; rs13325669; rs13060326; rs13080485; rs11914648; rs6776343; rs17064521; rs9878383; rs9820196; rs9849906; rs11719785; rs17685796; rs4679555; rs13099811; rs6809031; rs17063494; rs7629014; rs6446182; rs9877774; rs2594119; rs17634592; rs6797229; rs17064044; rs9836650; rs9825016; rs3915074; rs13085845; rs2364300; rs17627239; rs9849318; rs9854360; rs9877573; rs6767530; rs12633756; rs2594273; rs2077099; rs11130792; rs7631312; rs6796455; rs2856033; rs241673; rs9818475; rs9829453; rs9858247; rs2736752; rs241677; rs17063973; rs6776129; rs11706057; rs9871813; rs11720347; rs17064394; rs11130836; rs7646138; rs13093251; rs9875066; rs1716729; rs1868222; rs7374239; rs4679548; rs7618397; rs13061562; rs9880620; rs17637725; rs9837219; rs1716726; rs9754707; rs12488640; rs1967348; rs2594149; rs6772360; rs17689493; rs2205358; rs13086399; rs12491075; rs2736746; rs11715779; rs17670946; rs9880322; rs6773644; rs9838372; rs7611105; rs11716427; rs12494269; rs17668356; rs17064660; rs17630955; rs17668266; rs9311799; rs13068401; rs7624473; rs2682976; rs9682234; rs12489644; rs17064663; rs13068278; rs1880216; rs7611232; rs7640515; rs7373003; rs17064482; rs961374; rs9876966; rs751252; rs2064013; rs6763941; rs13314073; rs34412028; rs4558709; rs12488704; rs7610473; rs17064608; rs11130781; rs9846162; rs6446138; rs6782953; rs17064657; rs6782111; rs2365049; rs7622539; rs13067370; rs9845924; rs6787793; rs2736759; rs1447916; rs4688361; rs9917837; rs7633753; rs9827827; rs7643657; rs13087596; rs6446161; rs12108196; rs13326701; rs2594151; rs9680926; rs17063998; rs502739; rs17064007; rs17630913; rs6808935; rs241685; rs7639878; rs7610331; rs11927051; rs17063678; rs12495135; rs9881064; rs6764320; rs7622729; rs11918601; rs9864410; rs7638707; rs9880158; rs6808123; rs9864591; rs17064309; rs9856644; rs7609688; rs12491171; rs17064303; rs1868221; rs9839700; rs6775530; rs9869424; rs11921624; rs9813886; rs12638876; rs7636351; rs17064187; rs13087524; rs11130799; rs6804167; rs1947159; rs9311797; rs9815842; rs11708288; rs2121843; rs2365492; rs6787911; rs17063868; rs1623840; rs7653023; rs4974246; rs2736753; rs12497605; rs34894181; rs9851252; rs6797465; rs11921411; rs4458323; rs6791206; rs1614618; rs7612282; rs9848705; rs13099397; rs4600784; rs7613524; rs2594142; rs1868228; rs6797125; rs7638056; rs11130801; rs17064638; rs17064508; rs9830950; rs1620446; rs6768016; rs7653005; rs6769253; rs3772442; rs17064318; rs6764332; rs1716719; rs11130806; rs7428745; rs1014856; rs9856559; rs17064511; rs1374917; rs7612462; rs17064323; rs13097786; rs13100376; rs9876067; rs7638932; rs9859251; rs9871619; rs13063948; rs1584340; rs6446162; rs10866040; rs1716706; rs4414847; rs17064379; rs4688146; rs9847513; rs1716710; rs9853773; rs180983; rs17063917; rs13085258; rs13084123; rs1005463; rs9882247; rs17063933; rs9880965; rs9819146; rs17064624; rs17685826; rs13071895; rs9855482; rs9865526; rs9844774; rs9827752; rs12487914; rs6797903; rs2166823; rs9858841; rs9853053; rs12486043; rs12491946; rs13074513; rs13066622; rs11921857; rs13090600; rs7636450; rs1735467; rs9880233; rs11130797; rs17063967; rs7626939; rs17063914; rs17063928; rs6808912; rs13067083; rs9847131; rs9871232; rs2118812; rs9843941; rs17064316; rs1735448; rs2156968; rs7643983; rs11715778; rs6787595; rs9820776; rs9881646; rs17064083; rs13073028; rs17063950; rs12498136; rs9850114; rs17063921; rs6768800; rs9879312; rs7640288; rs34045993; rs11714293; rs9755687; rs11921597; rs13323456; rs9868708; rs13093294; rs9875292; rs9840977; rs11715674; rs2594170; rs2213216; rs4256080; rs17063781; rs1735458; rs1735477; rs9823919; rs4117970; rs2886255; rs13100872; rs2246924; rs7633805; rs17685772; rs17063886; rs13095410; rs9838678; rs2142295; rs11926163; rs12497047; rs241675; rs11715704; rs2364293; rs7648908; rs9819767; rs11921655; rs11922545; rs7649286; rs9870639; rs7632682; rs1735479; rs6446184; rs12491421; rs9835901; rs1716740; rs9879049; rs2594171; rs7636127; rs9830935; rs17637774; rs9851218; rs1735470; rs9827553; rs7633027; rs12492639; rs13099063; rs2856040; rs2205347; rs17064357; rs11718931; rs9842721; rs1357639; rs13074190; rs13067855; rs9863189; rs9867295; rs2856047; rs2682974; rs17064182; rs4974253; rs2363670; rs11914311; rs4425247; rs1868224; rs17064314; rs17064653; rs9831393; rs6805502; rs12486851; rs9757313; rs9842102; rs9857504; rs9855480; rs9871019; rs6785032; rs4533645; rs1716723; rs9872622; rs9831698; rs6804218; rs9860688; rs9874458; rs17064376; rs6801955; rs9842547; rs6774523; rs9851737; rs1716713; rs1997582; rs17064028; rs242186; rs7613634; rs9852160; rs2083265; rs2091955; rs11711696; rs9863908; rs9868283; rs13085356; rs2856058; rs13080291; rs9856189; rs6446152; rs9311793; rs2118813; rs2594162; rs11927658; rs17064327; rs6445193; rs1447920; rs1123707; rs2682961; rs9866509; rs7612078; rs6764497; rs7636568; rs1447958; rs9834070; rs11706267; rs9838669; rs6794059; rs9853958; rs9714003; rs11926008; rs4974228; rs11917858; rs12492939; rs2365055; rs12715564; rs1716751; rs13314853; rs9866842; rs17670154; rs1868219; rs241684; rs9877106; rs2856008; rs7649524; rs9871584; rs9859800; rs1716736; rs11721114; rs13087353; rs7627230; rs4679552; rs13078972; rs12630519; rs17635515; rs1716711; rs6763084; rs9311789; rs12489480; rs9875827; rs7622334; rs2594150; rs1439007; rs1735472; rs1735473; rs17063746; rs9833913; rs11130814; rs11716669; rs3952441; rs12488010; rs6777641; rs1716725; rs241681; rs11927450; rs2856028; rs2594148; rs1947160; rs2594160; rs6763967; rs11130774; rs17634713; rs17063916; rs12107926; rs6799687; rs9758573; rs9817183; rs13079949; rs11720254; rs9850221; rs7610986; rs2682982; rs17633748; rs9836068; rs7374366; rs9849492; rs6785481; rs17064396; rs9812794; rs13087160; rs6777715; rs6767142; rs2156975; rs6802913; rs12632090; rs7619351; rs12497501; rs6446132; rs6766863; rs9850579; rs9876522; rs9311798; rs9820783; rs1447960; rs2594140; rs2736796; rs212016; rs1040337; rs212034; rs720285; rs1797563; rs213386; rs242209; rs2611414; rs213385; rs1523115; rs2734380; rs213408; rs1447981; rs213328; rs744192; rs2630206; rs994929; rs294457; rs2736784; rs931321; rs1569348; rs681119; rs675411; rs2687165; rs294459; rs591934; rs213388; rs242213; rs969562; rs1040335; rs639244; rs2736821; rs294461; rs172492; rs963685; rs1014595; rs1546817; rs213318; rs1666066; rs2736777; rs2367106; rs2049849; rs1472369; rs810525; rs1882898; rs1485734; rs212003; rs169913; rs1546830; rs1026989; rs213316; rs213309; rs687069; rs2630184; rs1353546; rs1352021; rs610766; rs400475; rs2630186; rs398322; rs183322; rs213336; rs809710; rs760322; rs213323; rs1569351; rs212066; rs736934; rs2121866; rs294453; rs802778; rs213400; rs213347; rs212051; rs612759; rs780366; rs2687163; rs390523; rs2121862; rs2630207; rs1385814; rs2132608; rs213322; rs1447974; rs2017941; rs2121865; rs294458; rs1874500; rs212023; rs2630173; rs810615; rs1357320; rs242171; rs445057; rs1474525; rs241693; rs212065; rs1496651; rs1353545; rs213384; rs984757; rs394509; rs212058; rs1947162; rs213342; rs1117870; rs213387; rs426569; rs624225; rs1882904; rs1569352; rs2736823; rs213306; rs49411; rs294454; rs492836; rs182418; rs213319; rs2687170; rs646372; rs1817587; rs1973780; rs2361341; rs2734361; rs213389; rs213394; rs1546831; rs2142301; rs1569349; rs780345; rs213401; rs780358; rs1485730; rs241706; rs760323; rs242197; rs1447976; rs2736764; rs923141; rs2121867; rs398105; rs1569354; rs2630172; rs732380; rs2687194; rs1057504; rs983946; rs2121863; rs2594250; rs51549; rs2361336; rs213392; rs750793; rs7634921; rs151749; rs2736760; rs1038516; rs741898; rs1882899; rs9835300; rs4679533; rs7634772; rs9311738; rs677703; rs2253211; rs2142302; rs11711026; rs12636057; rs9878446; rs6794056; rs2734389; rs9819920; rs9850852; rs242222; rs213398; rs6789538; rs385483; rs4566489; rs7615466; rs1022418; rs4468936; rs1496652; rs2687169; rs212040; rs4393860; rs11915344; rs6764575; rs452392; rs481165; rs213370; rs7624537; rs9810994; rs594063; rs3845973; rs6446122; rs609891; rs453951; rs2049848; rs13088111; rs9839662; rs993000; rs6773500; rs9854540; rs397227; rs17493; rs728519; rs9844365; rs212060; rs3732551; rs6787664; rs9284900; rs213315; rs6802584; rs7433793; rs213354; rs4679478; rs12487617; rs378022; rs3772475; rs684584; rs4679650; rs213418; rs212004; rs12636081; rs1569353; rs9815526; rs2173056; rs9311755; rs391844; rs7638558; rs2064017; rs722070; rs3843360; rs375127; rs7615052; rs212014; rs6764498; rs186153; rs9881736; rs1569355; rs6446117; rs534185; rs931317; rs1349019; rs294455; rs6784469; rs1485723; rs1496649; rs213308; rs6446102; rs6777599; rs4679526; rs12486718; rs2383; rs213373; rs2630181; rs11130754; rs169915; rs12633119; rs212009; rs9841239; rs1825630; rs9877486; rs6764256; rs685970; rs9846213; rs2197751; rs6764060; rs4638920; rs2687167; rs926143; rs213396; rs6800973; rs1569350; rs11130745; rs7635477; rs2736794; rs7618479; rs1385812; rs1385715; rs13314734; rs4679647; rs213348; rs802774; rs6781354; rs9837070; rs12638426; rs1882903; rs4679639; rs9881070; rs2293212; rs7631068; rs1947161; rs2687181; rs767000; rs2064019; rs7624360; rs983947; rs9311756; rs7644138; rs7621114; rs986651; rs430036; rs6446101; rs994930; rs7616694; rs212027; rs213352; rs7615959; rs6446097; rs2366964; rs11130752; rs1905866; rs1385716; rs7616955; rs6779494; rs809098; rs2611403; rs741753; rs7611775; rs6768883; rs7642268; rs1380466; rs212044; rs2049846; rs9829607; rs4679524; rs410351; rs9311749; rs9880343; rs213368; rs12494639; rs780362; rs6807027; rs4679511; rs640115; rs212064; rs7622441; rs9813457; rs13323989; rs2630149; rs213376; rs9856574; rs400747; rs780359; rs2171130; rs4679618; rs11707031; rs2736778; rs6807624; rs9848065; rs6797780; rs3907341; rs212015; rs294451; rs7619422; rs2734376; rs4679643; rs2885639; rs7647621; rs6786862; rs726692; rs7643828; rs13316872; rs9814467; rs213414; rs4413275; rs7641743; rs2361335; rs213395; rs575614; rs212032; rs7651340; rs11130746; rs9311746; rs4485674; rs212031; rs4295132; rs213366; rs11718208; rs368926; rs6771886; rs177139; rs2101339; rs2361340; rs7643604; rs6446089; rs7642167; rs3856668; rs9842521; rs6772047; rs7646666; rs9311758; rs7637894; rs12638728; rs802772; rs6799964; rs6764937; rs11717200; rs953480; rs212055; rs809097; rs6782631; rs4679476; rs780364; rs6801889; rs926140; rs6808467; rs242195; rs386348; rs212018; rs1496650; rs3772448; rs7626928; rs6808645; rs452203; rs6446129; rs6797046; rs3845970; rs1813201; rs11130751; rs2142300; rs13077692; rs10510839; rs213304; rs678981; rs11130756; rs3912493; rs9867642; rs2736783; rs12489534; rs7636619; rs4679520; rs1874501; rs1996829; rs6800393; rs3821487; rs213382; rs1447971; rs4679516; rs1057501; rs2687159; rs6780483; rs4679615; rs11130767; rs6768755; rs9874387; rs7621132; rs213407; rs2049847; rs727476; rs6446085; rs7627449; rs212061; rs6778218; rs3772476; rs2251216; rs242214; rs9851189; rs11720615; rs384530; rs212006; rs9311754; rs3772500; rs9826530; rs3915504; rs7651806; rs7627398; rs11130770; rs717821; rs2736766; rs3912494; rs7426703; rs213344; rs6797203; rs931322; rs11708562; rs10780042; rs7640460; rs12489018; rs2366968; rs430815; rs684753; rs186154; rs213299; rs1038517; rs741897; rs11926112; rs3845972; rs212063; rs1983535; rs3911035; rs7609578; rs6780146; rs6446104; rs6780613; rs213333; rs9311733; rs6786100; rs812964; rs241698; rs9829623; rs1390763; rs673870; rs6776575; rs4679545; rs177138; rs7645600; rs2142305; rs6777402; rs7649971; rs7625937; rs6446103; rs10510833; rs12152244; rs4679507; rs1006901; rs9871368; rs2629877; rs9682976; rs411076; rs6783802; rs2687168; rs6773849; rs4679651; rs780354; rs213320; rs9809480; rs9311741; rs4679648; rs12636197; rs1390765; rs7648865; rs6446090; rs7616124; rs2205361; rs213364; rs2736830; rs9817995; rs2630161; rs9311739; rs6775757; rs1597103; rs393593; rs2630182; rs213339; rs722071; rs12330869; rs212020; rs12492065; rs4679614; rs6768625; rs6781130; rs9825594; rs1967997; rs7626003; rs12638410; rs3772506; rs12632711; rs7623130; rs9817116; rs6788821; rs2736801; rs212048; rs969561; rs802780; rs12633077; rs936823; rs6783655; rs9813516; rs972795; rs3821480; rs7644852; rs6776005; rs10510845; rs212036; rs1485731; rs6763524; rs1447973; rs9839805; rs4679626; rs2736779; rs3915503; rs562516; rs3772482; rs2736812; rs1823242; rs2630183; rs241704; rs9853482; rs6802679; rs7629068; rs7626208; rs2366952; rs2736808; rs6807084; rs4234288; rs2736795; rs2630148; rs2734377; rs7643511; rs2220227; rs373730; rs6762886; rs151739; rs11721188; rs1872494; rs213411; rs7625787; rs9868281; rs9868156; rs7629400; rs1385815; rs11130753; rs378346; rs2064016; rs12487051; rs9816955; rs6795869; rs7610403; rs4679631; rs6762119; rs9814637; rs6446100; rs2885254; rs1485727; rs2166824; rs926141; rs6446130; rs615542; rs9311747; rs1996828; rs191927; rs49413; rs9865672; rs802771; rs6779529; rs9874888; rs7647196; rs10866034; rs7612797; rs9311748; rs6804909; rs2630165; rs6808129; rs802933; rs3732552; rs6773826; rs9830999; rs241701; rs3772445; rs4375999; rs12633138; rs4615035; rs7649040; rs1879996; rs7643424; rs1579912; rs9814351; rs9882907; rs213317; rs377319; rs440450; rs11130769; rs6801030; rs385245; rs12715550; rs741896; rs802777; rs2049845; rs9878437; rs995633; rs7615700; rs662910; rs381217; rs3845971; rs7640107; rs2736780; rs151743; rs9882944; rs10510847; rs3772505; rs1550925; rs13071758; rs213324; rs12636662; rs6804216; rs677264; rs996174; rs4083381; rs4679627; rs565226; rs9867241; rs6784012; rs9819258; rs2734363; rs9828226; rs3856669; rs734156; rs6766789; rs3772484; rs1079196; rs7613687; rs6769366; rs6795591; rs172454; rs2736765; rs143017; rs11711589; rs3856654; rs605545; rs11130741; rs7643042; rs10866033; rs582381; rs212043; rs2736825; rs3772447; rs9829514; rs212057; rs11718018; rs11920657; rs12637099; rs6795827; rs6446119; rs6778312; rs1485732; rs13061155; rs683809; rs9311745; rs13324247; rs6446096; rs17366680; rs9883016; rs212049; rs11711468; rs760316; rs13090091; rs2630143; rs9832192; rs7645258; rs17062179; rs2361337; rs6771732; rs4679640; rs659205; rs12490525; rs294463; rs9311750; rs9822030; rs17314469; rs2630174; rs17061792; rs7636374; rs9813806; rs12496632; rs633798; rs7630823; rs9822070; rs2736791; rs17063058; rs9835376; rs212062; rs9818696; rs12492267; rs12493170; rs17364716; rs10510826; rs10510834; rs650905; rs7623479; rs7627604; rs9879860; rs17061573; rs6793324; rs1006902; rs6808530; rs6446083; rs9863826; rs9868373; rs7611670; rs2629883; rs9881133; rs17254765; rs9809345; rs1447970; rs633189; rs9881653; rs550626; rs213423; rs17031569; rs11130747; rs17062796; rs17399247; rs2077587; rs2629884; rs6446125; rs17063425; rs7427130; rs11708661; rs11925321; rs17062101; rs13315808; rs10510842; rs521388; rs11706778; rs2630199; rs212011; rs11919455; rs12498050; rs9860090; rs12485388; rs6764230; rs17258256; rs10084745; rs212028; rs10510821; rs6810051; rs17063477; rs381450; rs13067835; rs3772468; rs213343; rs9823838; rs11924368; rs6792176; rs9828971; rs7619137; rs17061789; rs1683366; rs6806175; rs7637396; rs9852328; rs9869160; rs6766477; rs6789978; rs9985431; rs650215; rs9861525; rs7640017; rs810616; rs6791718; rs17061321; rs17395220; rs9827643; rs13088717; rs213295; rs6791450; rs12497400; rs6446127; rs3931996; rs11928100; rs1905865; rs6766262; rs3772487; rs11708751; rs10510836; rs11130736; rs521599; rs7625421; rs9879175; rs6797839; rs9851038; rs9877074; rs213351; rs17661314; rs241705; rs780360; rs6779755; rs1983536; rs12637950; rs6765826; rs11714243; rs9311762; rs12492234; rs3772501; rs2611410; rs12330253; rs9819930; rs7645058; rs12494319; rs6768598; rs6785232; rs7644970; rs9867348; rs17062609; rs12629710; rs17061180; rs9879807; rs212053; rs2362881; rs13075135; rs7647923; rs13064036; rs9874674; rs17336290; rs17062405; rs12495052; rs9861715; rs2736818; rs7653425; rs655011; rs17063156; rs9881669; rs11718994; rs17063427; rs6792440; rs9848465; rs623014; rs17061728; rs1882901; rs7615432; rs587959; rs510794; rs1683354; rs2736767; rs6804301; rs17062850; rs11715925; rs9820238; rs995467; rs17061763; rs9311767; rs11707595; rs9820066; rs9857010; rs7628950; rs6791049; rs13101027; rs6778206; rs6778121; rs7638267; rs17302837; rs12638665; rs965033; rs3772497; rs2630190; rs104795; rs13317306; rs17254574; rs9864403; rs12496532; rs2687189; rs9882551; rs17061708; rs4679628; rs12495450; rs643629; rs191926; rs213410; rs11924823; rs2611411; rs3772444; rs11707816; rs10490808; rs672802; rs212038; rs11917585; rs1349021; rs477697; rs6803131; rs3772464; rs4679630; rs11718957; rs932273; rs10510832; rs4432588; rs2687193; rs6789565; rs6797901; rs410072; rs9812269; rs7610652; rs12632865; rs6771240; rs412104; rs3772446; rs425036; rs11709255; rs12486972; rs17396765; rs6782148; rs9865813; rs670592; rs9831415; rs10510844; rs526773; rs9860107; rs11718430; rs213375; rs17061650; rs213381; rs9865210; rs13072228; rs13081934; rs17322850; rs2630166; rs9875624; rs6803449; rs2736816; rs4679530; rs2605432; rs10510831; rs12632178; rs6783454; rs2594264; rs2366953; rs9811336; rs13094437; rs17062824; rs6763641; rs17061182; rs9985430; rs17062524; rs3772498; rs9868731; rs3915502; rs2630170; rs9881224; rs6797938; rs1872495; rs11916155; rs17061844; rs2630203; rs9637471; rs3772483; rs17061377; rs17062497; rs9822178; rs17061346; rs7628314; rs6807405; rs7636129; rs11717164; rs6801817; rs6788677; rs688947; rs9311753; rs12497746; rs10510837; rs6783428; rs213325; rs12488124; rs492695; rs13066837; rs2734372; rs6806167; rs13070872; rs13434180; rs17061331; rs2630200; rs13098396; rs3821484; rs12634148; rs2736781; rs2630177; rs3856663; rs3772479; rs2088311; rs2629879; rs9825867; rs9837246; rs11928015; rs780368; rs652105; rs17296168; rs7652771; rs9877256; rs2205042; rs1882735; rs4679642; rs11715441; rs213391; rs10510829; rs12630887; rs1485717; rs3821477; rs9868048; rs10510841; rs9847570; rs12489929; rs13090962; rs6772201; rs606415; rs7622148; rs9841531; rs9823026; rs17062981; rs637820; rs9830224; rs17062882; rs11926935; rs7616522; rs17063416; rs242225; rs9681919; rs1683347; rs6772278; rs3856665; rs780348; rs10510822; rs17062963; rs11922239; rs3772508; rs9311736; rs7632050; rs17397398; rs17062799; rs17062892; rs143018; rs760317; rs12487096; rs9311737; rs2736826; rs17061897; rs17668453; rs4679527; rs6800257; rs213406; rs6789112; rs6446115; rs492234; rs11130739; rs9682987; rs9311744; rs620113; rs6782294; rs17061494; rs17061880; rs369161; rs2064020; rs604398; rs994928; rs11717293; rs17295070; rs12493207; rs13078190; rs885737; rs6446120; rs3772503; rs241700; rs9862380; rs6806748; rs169840; rs10510846; rs6800951; rs13058814; rs7631389; rs6775598; rs3912495; rs3772474; rs17362486; rs213307; rs9876685; rs17061388; rs9846621; rs9846216; rs12498046; rs9862811; rs9884086; rs213363; rs6789802; rs11924342; rs3890406; rs1666057; rs17299801; rs11922668; rs17062005; rs2049850; rs9820943; rs9853451; rs812445; rs1390766; rs17379746; rs6807277; rs13059195; rs6791776; rs17258872; rs213416; rs11707783; rs6776721; rs11923964; rs7633785; rs17361653; rs9847063; rs17338297; rs9842655; rs12485617; rs2262979; rs7653008; rs213359; rs2687177; rs383111; rs7641930; rs11924551; rs7433134; rs3821479; rs1666058; rs3772504; rs12715552; rs17062315; rs11716358; rs17062579; rs2594248; rs9834844; rs931318; rs9311751; rs1447980; rs12172960; rs6784057; rs17061328; rs11714913; rs2629882; rs590581; rs212017; rs9877140; rs7621056; rs213357; rs17061825; rs10510843; rs11714533; rs7641937; rs12492663; rs10510820; rs4142702; rs11715245; rs6765124; rs11711227; rs212033; rs974035; rs6446126; rs17325940; rs2630191; rs6446113; rs11917112; rs13063836; rs2736782; rs212042; rs13100448; rs3856659; rs11130763; rs6789642; rs9881093; rs17610429; rs9876544; rs2276732; rs734291; rs409484; rs11916801; rs606735; rs368553; rs213390; rs3772462; rs4679531; rs6766165; rs1995067; rs659193; rs7627733; rs1040336; rs4679544; rs17746541; rs6798840; rs9838143; rs10433635; rs6768733; rs11921348; rs17609699; rs2687161; rs1569347; rs369278; rs6784545; rs9826111; rs2630144; rs9863246; rs12486710; rs169841; rs2361338; rs2630180; rs17061847; rs213399; rs12629469; rs11916042; rs9834447; rs17062363; rs9814915; rs213371; rs1580457; rs11719244; rs9813494; rs2361339; rs17061683; rs6802153; rs17063335; rs6773600; rs802779; rs9875546; rs9877008; rs7642242; rs6768904; rs17062113; rs17062633; rs3856667; rs17257269; rs7653872; rs17253376; rs10510825; rs11708404; rs2736810; rs9810084; rs13090516; rs995468; rs11921834; rs213377; rs17361780; rs11916072; rs17302363; rs11921436; rs3772453; rs1350638; rs12493686; rs9855384; rs9824412; rs2630198; rs242192; rs212001; rs11130761; rs12488398; rs17061893; rs493783; rs6807325; rs17301211; rs632140; rs1882900; rs213412; rs7615522; rs12492175; rs9311752; rs585448; rs3772471; rs7349527; rs9883913; rs11920587; rs172456; rs760324; rs607730; rs11917125; rs17301008; rs17256369; rs9875209; rs7650052; rs6792218; rs9831397; rs9815054; rs2630154; rs7649422; rs12487545; rs9878583; rs411734; rs17658463; rs391770; rs1843399; rs294464; rs6764133; rs780361; rs2594239; rs9813549; rs1447972; rs780369; rs12635040; rs9821428; rs17395248; rs13064050; rs991783; rs3772467; rs12495662; rs4679477; rs6794055; rs9816428; rs4679541; rs9681598; rs9853628; rs4679542; rs10510835; rs2630187; rs11918446; rs7644699; rs9825541; rs9866142; rs9843313; rs9872356; rs212041; rs10490773; rs11917733; rs2734387; rs12487741; rs13074132; rs9817793; rs11706898; rs10510827; rs9855046; rs2253303; rs213300; rs4393861; rs4679523; rs7619114; rs3772502; rs9867457; rs17394135; rs7635514; rs9838518; rs17061239; rs9824750; rs213420; rs642214; rs10049216; rs433401; rs9827257; rs12638086; rs410552; rs13066381; rs4679606; rs242172; rs13092167; rs7634961; rs12489848; rs12486936; rs3772473; rs741751; rs7645607; rs3772489; rs2178929; rs11720966; rs623032; rs9868816; rs1016450; rs17314091; rs589522; rs659664; rs3845974; rs3772499; rs13314184; rs12374046; rs12638206; rs12636241; rs1084008; rs13100563; rs17379551; rs802775; rs213415; rs10510838; rs12487526; rs13098699; rs17061712; rs213326; rs602197; rs11130766; rs212039; rs6783772; rs408164; rs9821564; rs9833203; rs4679538; rs780370; rs9311726; rs6788803; rs6779785; rs981852; rs687342; rs9814473; rs9825234; rs6800049; rs10428174; rs10212340; rs4679521; rs1905863; rs471011; rs6446114; rs9876121; rs9881474; rs3772496; rs3845976; rs17295225; rs11715209; rs17256807; rs17062503; rs12633994; rs2734373; rs12635633; rs4468937; rs17062647; rs7615407; rs628404; rs212059; rs213353; rs2687182; rs3772454; rs11716199; rs11708236; rs6773303; rs9862817; rs9311742; rs17061176; rs2630194; rs1485733; rs12487204; rs3796193; rs2630202; rs2629880; rs17061478; rs434054; rs6789183; rs1597104; rs1349020; rs6446121; rs7635362; rs6446087; rs213297; rs1385713; rs9823903; rs2205038; rs2605434; rs213402; rs11706913; rs9311757; rs169914; rs17061982; rs4596100; rs2630168; rs13061510; rs9881795; rs9879616; rs9856634; rs11709440; rs9871183; rs17600182; rs11707726; rs13095141; rs9862176; rs212046; rs6762611; rs17375746; rs7614540; rs9844132; rs9681146; rs3772460; rs6779107; rs9818349; rs17599845; rs9849664; rs9827995; rs9860134; rs212050; rs7646323; rs675774; rs6794968; rs6800603; rs2611415; rs7645880; rs6446109; rs9852627; rs17255936; rs2736793; rs17339157; rs17374239; rs9827176; rs17062684; rs183330; rs17061746; rs597224; rs9862003; rs9870612; rs9849539; rs13096138; rs11921950; rs780712; rs12493494; rs17061173; rs780714; rs6769478; rs3901943; rs2734390; rs213346; rs2064018; rs12715549; rs809076; rs9848952; rs874239; rs9836899; rs6784140; rs9810520; rs6804914; rs7612646; rs3912492; rs2630201; rs505780; rs213383; rs17302202; rs616503; rs17062321; rs12490649; rs7615233; rs17323271; rs241688; rs4024131; rs6446128; rs2687158; rs4679610; rs9882623; rs736935; rs4679608; rs4145506; rs9837820; rs2687176; rs10510828; rs780365; rs6771484; rs2088310; rs780343; rs7623993; rs2367105; rs9824900; rs10510840; rs11926327; rs2630179; rs3772509; rs3856662; rs9841314; rs9878487; rs726693; rs7644933; rs6803403; rs9830740; rs12636019; rs6787076; rs1566056; rs7647491; rs17062116; rs9826272; rs2687899; rs12497472; rs293605; rs11719292; rs11717136; rs11711608; rs3821478; rs9856484; rs11715172; rs7641023; rs212052; rs9847855; rs9852001; rs9815786; rs10510823; rs6446099; rs213335; rs11924296; rs598678; rs9837060; rs3772507; rs213380; rs2605442; rs11707269; rs213356; rs953479; rs9813412; rs1948560; rs931320; rs1021227; rs6446123; rs17061923; rs741895; rs17376767; rs12493462; rs13087782; rs2064021; rs517644; rs4679475; rs6771504; rs213298; rs7637895; rs17374441; rs400620; rs780716; rs11915972; rs7634619; rs213302; rs17062557; rs3772485; rs12494512; rs17254231; rs1872531; rs6780176; rs13101214; rs2736819; rs13097687; rs213313; rs552676; rs1979076; rs17061246; rs423629; rs6771698; rs13067992; rs9832961; rs13070338; rs13434177; rs7648665; rs17062460; rs2446705; rs11130731; rs17365142; rs17374559; rs17600161; rs13063413; rs17296496; rs17063191; rs12490126; rs9855582; rs213311; rs2611408; rs760318; rs12496762; rs11130765; rs17061776; rs212007; rs393930; rs13098406; rs17061684; rs6797474; rs2594258; rs12492390; rs3856664; rs17398712; rs2228695; rs11130762; rs151747; rs7611309; rs17061248; rs1385710; rs17061368; rs17061932; rs213301; rs9809808; rs13086424; rs4679635; rs11925272; rs17366548; rs12632371; rs2605437; rs493345; rs1447975; rs6783730; rs242193; rs1352020; rs780372; rs241692; rs17301647; rs213358; rs1948562; rs780346; rs17061336; rs17063405; rs9845306; rs11720903; rs11923919; rs2461613; rs7650150; rs2734404; rs9829234; rs2121864; rs6797140; rs2086977; rs9870292; rs17062419; rs9872138; rs13434367; rs17062510; rs9875864; rs1038515; rs9879753; rs446714; rs7627676; rs12638815; rs3856658; rs7373797; rs9824566; rs9837647; rs6446110; rs12636523; rs13062399; rs3772466; rs9839495; rs17061231; rs9851805; rs2736803; rs2046455; rs11928686; rs6793429; rs6808425; rs2629894; rs151740; rs9851655; rs17062206; rs621666; rs615832; rs2630175; rs17063479; rs379394; rs17061517; rs9812704; rs2611401; rs2201649; rs6784936; rs11925432; rs213421; rs17062527; rs6803162; rs2630205; rs9819370; rs9853194; rs11130733; rs6806511; rs9877308; rs17063011; rs972794; rs294452; rs13069706; rs13325381; rs7648380; rs17063104; rs6781028; rs13081936; rs17296701; rs11916728; rs1683349; rs591947; rs3911036; rs2594246; rs212047; rs242174; rs7622382; rs17400084; rs7646022; rs2736786; rs13322304; rs2630167; rs9876417; rs9812396; rs6792115; rs17302746; rs6790477; rs12715551; rs12486471; rs3112498; rs555026; rs4679629; rs17061241; rs612947; rs400870; rs11130760; rs3772477; rs213365; rs6798364; rs11130748; rs213404; rs11920482; rs9311729; rs6776435; rs2594266; rs7615352; rs9826469; rs430270; rs17061744; rs7625054; rs413942; rs17062458; rs7636422; rs415832; rs13060068; rs7623184; rs7644553; rs9875448; rs9812343; rs584551; rs17061475; rs17063325; rs17254898; rs3772452; rs17061910; rs6786355; rs17061366; rs6779703; rs17062691; rs9873291; rs213369; rs17061540; rs9826315; rs9843907; rs675743; rs3772470; rs2736761; rs4234290; rs583363; rs4479546; rs12490629; rs6793471; rs17295332; rs1809540; rs17063126; rs7638091; rs926142; rs17062563; rs9842626; rs10470622; rs17061316; rs401810; rs9824783; rs6793646; rs13070475; rs213338; rs10154846; rs2630196; rs17062346; rs2630189; rs17061164; rs424675; rs2611409; rs17063428; rs17400197; rs4455289; rs17061197; rs17063024; rs1447968; rs17254065; rs9860649; rs1908771; rs17061250; rs10866035; rs13316416; rs17061895; rs9831509; rs17062148; rs17062372; rs7642732; rs212000; rs2103474; rs2629896; rs780344; rs17062361; rs1380467; rs9871450; rs11130742; rs11926030; rs17363039; rs11717219; rs17061342; rs9835058; rs7628063; rs17063090; rs7631677; rs2366965; rs11711525; rs9877688; rs3836268; rs9818726; rs7645950; rs9844074; rs242198; rs9826614; rs9846395; rs13316980; rs2736763; rs213349; rs17062003; rs17063095; rs2630147; rs2293211; rs13316171; rs4426638; rs7614564; rs7649027; rs6809984; rs1531334; rs13327150; rs2223086; rs213355; rs213341; rs4679518; rs4679609; rs4024129; rs6765570; rs17062553; rs526389; rs17061699; rs17062150; rs17062662; rs12633701; rs11715564; rs7615116; rs6787059; rs3821485; rs11708267; rs6779449; rs2736807; rs17062415; rs13319697; rs9833555; rs6776492; rs17061765; rs6807483; rs17031605; rs17668326; rs17063248; rs7639576; rs2734379; rs423336; rs2736792; rs17063200; rs4679529; rs17258709; rs17062578; rs9823129; rs4632501; rs17062603; rs17397822; rs7620217; rs294462; rs606168; rs241687; rs293604; rs669229; rs9851197; rs2594251; rs9849856; rs17063484; rs4679522; rs689497; rs1905864; rs541960; rs497767; rs17062506; rs212013; rs545783; rs12107407; rs11718220; rs17063443; rs7616359; rs9836506; rs9817691; rs12493585; rs213310; rs1843538; rs7648647; rs13070051; rs9820356; rs2605441; rs17061837; rs17031558; rs874238; rs17062353; rs242212; rs2629891; rs11715819; rs6446093; rs9818342; rs9839754; rs6792533; rs6763743; rs2734354; rs13064561; rs586011; rs12490626; rs2630164; rs293606; rs9879843; rs2605435; rs3772491; rs622875; rs1159236; rs17062454; rs7645438; rs242241; rs2687152; rs9818182; rs13318087; rs17062392; rs17061162; rs12635905; rs6781179; rs6773713; rs3845977; rs17606826; rs7610005; rs17319929; rs572459; rs12172945; rs13087386; rs7610087; rs6778142; rs4679625; rs411122; rs17061988; rs2171077; rs3772458; rs2630145; rs2121861; rs2362456; rs9863244; rs4679623; rs3856670; rs17061653; rs11130768; rs12638903; rs6446086; rs13314141; rs2687185; rs17061392; rs17257241; rs17061484; rs3856655; rs242196; rs17309998; rs9860752; rs11924684; rs780715; rs6774343; rs12637710; rs17365525; rs17061814; rs9860502; rs3821476; rs9867596; rs1040338; rs6776501; rs6790844; rs17061318; rs17061961; rs7634079; rs17061381; rs6777011; rs2734391; rs6792761; rs11130732; rs9874832; rs11712381; rs13060029; rs6767126; rs17061767; rs13099584; rs9847503; rs6782804; rs13075410; rs17061726; rs741752; rs213345; rs17765996; rs6782393; rs4679607; rs17062413; rs11927427; rs17061302; rs17609783; rs11929596; rs499323; rs13322587; rs17062284; rs17061186; rs2687895; rs9831022; rs2734383; rs17061689; rs11927585; rs10428177; rs17320834; rs3920478; rs242194; rs11925198; rs17061716; rs1485904; rs10154851; rs7373803; rs650197; rs13092173; rs17062953; rs17062786; rs17062707; rs17061373; rs9813727; rs12488248; rs7641720; rs2736817; rs17061428; rs10155027; rs1523116; rs2594268; rs1385811; rs9881665; rs12486187; rs675758; rs1683344; rs17063215; rs12633953; rs9870279; rs9851955; rs17063482; rs17063100; rs17063050; rs17062605; rs17375293; rs9815524; rs1948561; rs242201; rs10866032; rs213405; rs17062141; rs17325451; rs9809877; rs294460; rs4679505; rs17061335; rs2687150; rs12632643; rs11720196; rs9865027; rs7621164; rs4502542; rs211999; rs9833389; rs17062600; rs1374858; rs9817210; rs12639423; rs11713599; rs242226; rs212029; rs4679515; rs9855365; rs2736785; rs9867576; rs9856092; rs7629424; rs11719552; rs2594252; rs4679622; rs726409; rs563600; rs6806516; rs12495543; rs17062390; rs9311765; rs17061479; rs17061380; rs7653314; rs17062567; rs2630176; rs2046454; rs6784354; rs11715559; rs13095971; rs17061193; rs12629117; rs11920301; rs1970842; rs17061766; rs683908; rs213329; rs17061312; rs1564912; rs9834956; rs13096288; rs6776604; rs17320006; rs17609762; rs17061210; rs9882201; rs9813221; rs12152416; rs2736827; rs12630463; rs17061295; rs2629895; rs11720480; rs294450; rs7630255; rs212030; rs4289309; rs7622777; rs5014208; rs6784446; rs17062509; rs1843539; rs7646225; rs9855874; rs17607715; rs17658860; rs17061919; rs17062756; rs812444; rs11720431; rs17061408; rs9876422; rs13082004; rs12486873; rs12629886; rs6785656; rs17255191; rs11130734; rs17063018; rs9829333; rs7641907; rs9849125; rs6805528; rs1016449; rs17080828; rs6802579; rs17031575; rs4679637; rs213409; rs6783062; rs241665; rs9847443; rs17061812; rs10510830; rs9853625; rs415175; rs4679619; rs17063274; rs780347; rs17062344; rs213361; rs6772159; rs17063250; rs9829738; rs7643359; rs212008; rs12498126; rs7616500; rs17061326; rs3772450; rs6787894; rs12629851; rs780371; rs7626522; rs11130749; rs2734378; rs17061320; rs11928062; rs1022445; rs213327; rs7625055; rs17061338; rs1447962; rs9866689; rs971866; rs12497397; rs11916661; rs17061337; rs9880771; rs17062502; rs17063073; rs17255873; rs13084717; rs9871827; rs11717976; rs6806145; rs2736769; rs2178927; rs6771883; rs7628184; rs17817118; rs4605500; rs13088815; rs3772451; rs17324031; rs212025; rs9817092; rs2736787; rs4327338; rs4019443; rs17302126; rs13317933; rs17062272; rs17610098; rs2736824; rs9869016; rs9311730; rs6446111; rs2630178; rs17061232; rs6803318; rs6789121; rs13313901; rs17061269; rs11716313; rs9819455; rs575388; rs2687192; rs1845898; rs4608644; rs17254835; rs13072187; rs12486822; rs13324046; rs17301396; rs6446116; rs9311743; rs6791403; rs213294; rs6777815; rs2630204; rs9816712; rs17061678; rs213350; rs17301106; rs12635331; rs6777241; rs9813638; rs7643955; rs9858972; rs3112505; rs4679611; rs3112497; rs11130755; rs213374; rs2362889; rs2611404; rs7616806; rs17061972; rs2166790; rs9825127; rs3843359; rs626988; rs995466; rs151746; rs241695; rs9817027; rs17063438; rs9815796; rs17061181; rs17061385; rs9882078; rs2362888; rs9820451; rs7630991; rs17365190; rs2205041; rs17062519; rs9866478; rs2629899; rs4411839; rs12492524; rs10212612; rs11921963; rs17062191; rs7644751; rs17061398; rs12330860; rs9871341; rs9881466; rs9863289; rs17062269; rs13070349; rs13061158; rs12493500; rs17062513; rs9789989; rs7432036; rs7614251; rs11917122; rs7653300; rs1666064; rs517711; rs986015; rs17063317; rs11914464; rs1403200; rs242189; rs17062604; rs4284938; rs17062093; rs1352022; rs1456157; rs7646126; rs9863137; rs17061755; rs213340; rs9758551; rs4679617; rs7634622; rs9845099; rs478899; rs440692; rs4679508; rs13075738; rs7648572; rs9837503; rs1485725; rs9862666; rs17061546; rs17062890; rs2736762; rs17608587; rs4679512; rs7653213; rs9840704; rs12106924; rs213426; rs1485729; rs241694; rs12494015; rs212037; rs1629023; rs12635236; rs780935; rs17062350; rs17061780; rs213427; rs6805337; rs213337; rs2629889; rs17062324; rs2734375; rs473944; rs17062793; rs17062966; rs242224; rs9849524; rs1683356; rs4679479; rs17063275; rs17061900; rs17599894; rs167140; rs11710814; rs6795784; rs6765672; rs294456; rs213367; rs1380465; rs11130743; rs9883950; rs6776220; rs2736802; rs9861820; rs2687179; rs212045; rs17061705; rs11918355; rs17061444; rs9855768; rs9881503; rs9869623; rs12630613; rs9831755; rs7638084; rs6446092; rs34841206; rs11707548; rs2611417; rs17063396; rs492308; rs2611416; rs6806074; rs1564914; rs9876035; rs17061864; rs17061480; rs6767115; rs1038501; rs9834515; rs589792; rs633577; rs9311766; rs17061912; rs11921817; rs212019; rs9825503; rs6787176; rs2629875; rs11130764; rs2276733; rs9825153; rs4679624; rs17062367; rs2178930; rs10049212; rs213305; rs17063440; rs11708700; rs4679510; rs6786186; rs17063329; rs9829628; rs2734352; rs17061544; rs6765614; rs17062560; rs12638610; rs9863279; rs9819347; rs2687157; rs12163583; rs4124061; rs17061598; rs9876434; rs9873339; rs17063320; rs17062508; rs17061244; rs11720016; rs17300987; rs6780740; rs12107689; rs780367; rs212010; rs1385813; rs3772480; rs293603; rs241691; rs7642454; rs11922503; rs6804014; rs34600946; rs17296363; rs9829244; rs10470699; rs9837929; rs17063086; rs9822080; rs1485718; rs13319467; rs12638226; rs2629886; rs6802928; rs17050840; rs12629288; rs12629475; rs9828114; rs17299290; rs7636416; rs10470623; rs7646720; rs17606882; rs17062198; rs9816031; rs5012855; rs17061340; rs608582; rs4277641; rs9862819; rs9839118; rs125634; rs2362892; rs17062785; rs2200453; rs17362087; rs213424; rs17062611; rs689498; rs3821482; rs6801616; rs7636381; rs2605436; rs17061352; rs17061493; rs17609657; rs17658293; rs2629893; rs12633251; rs2736789; rs430766; rs9815985; rs11130750; rs439087; rs9828649; rs11922717; rs9862806; rs12495046; rs2687151; rs212054; rs17062360; rs17395576; rs7626013; rs7646420; rs4679641; rs7616048; rs17061253; rs2361333; rs17061322; rs9865682; rs12488566; rs9857624; rs12632676; rs13059601; rs7622557; rs2366966; rs970045; rs4679528; rs2736814; rs10222349; rs6446112; rs11917913; rs9883296; rs3772459; rs17599363; rs17062072; rs9838966; rs1996958; rs1628424; rs9866051; rs293602; rs9880846; rs9862543; rs12487811; rs1485724; rs35396167; rs2363674; rs28616691; rs28697197; rs35428632; rs1880215; rs34379697; rs10711092; rs9812744; rs35087705; rs10621998; rs11425388; rs7626047; rs35736825; rs36000584; rs11328354; rs1716731; rs34146546; rs6807024; rs10711853; rs7640222; rs7372992; rs13080876; rs180997; rs3037241; rs6764687; rs34955737; rs2594169; rs11324131; rs13074919; rs35267117; rs35545161; rs11359825; rs34626574; rs35710425; rs36022571; rs2682965; rs1584339; rs11420680; rs35093190; rs5029083; rs11276347; rs36071434; rs34674979; rs2364297; rs34462323; rs2594136; rs2682952; rs2856026; rs5849383; rs13091017; rs13077491; rs11329027; rs28797588; rs9683009; rs35626537; rs35583705; rs7633467; rs13073875; rs28393609; rs13098868; rs13096673; rs13315117; rs13076157; rs35763529; rs9856487; rs11468684; rs36054860; rs5849386; rs34365732; rs36121511; rs9875027; rs180988; rs34357389; rs35159710; rs180982; rs35356066; rs35640781; rs10534410; rs9883535; rs28548787; rs34703671; rs35164152; rs1716702; rs1898753; rs10698531; rs11283138; rs2682948; rs35026899; rs35599983; rs11915678; rs6446163; rs2856063; rs3074239; rs4688335; rs5849298; rs35367446; rs35422497; rs34649848; rs2682973; rs28420864; rs2121856; rs10461040; rs17063619; rs28581589; rs34166354; rs35388402; rs11712260; rs35601438; rs35005491; rs3060321; rs34226189; rs11357438; rs13073857; rs13075230; rs2859551; rs2856015; rs13065918; rs12054454; rs10576224; rs10694115; rs1974441; rs10575989; rs9871638; rs10669228; rs2121855; rs36045711; rs34766905; rs11130827; rs1735452; rs35513066; rs34436810; rs6446134; rs36058743; rs2156977; rs34706873; rs28448819; rs28550945; rs2594155; rs6787285; rs35166009; rs10703932; rs9637480; rs13081222; rs11712122; rs34276190; rs35463727; rs13064251; rs2040376; rs11456532; rs36150634; rs28670997; rs402064; rs35390919; rs13096823; rs34031319; rs34157668; rs36084042; rs5849393; rs9874497; rs12633777; rs2734347; rs11705843; rs35100604; rs9755753; rs34999446; rs2363672; rs9874571; rs11920919; rs13086168; rs13083532; rs36147560; rs11708561; rs34376484; rs35076933; rs36187720; rs34516655; rs34356910; rs9828263; rs13096211; rs34818699; rs1716728; rs1880217; rs6802917; rs151738; rs5849376; rs3074255; rs13069540; rs34877133; rs13074038; rs34391198; rs13100739; rs34800096; rs4688353; rs34628640; rs13316028; rs28411760; rs35171141; rs34207541; rs35871635; rs13063492; rs35871234; rs2856061; rs4974247; rs13078372; rs34944382; rs34196389; rs34108453; rs4435637; rs10621898; rs34744734; rs9844031; rs11927785; rs34870709; rs35499339; rs1965145; rs7643636; rs35150240; rs2734345; rs2226976; rs11337326; rs34551612; rs35582164; rs34271784; rs28551500; rs35012631; rs35311139; rs2682936; rs13090450; rs7609794; rs6782282; rs10704323; rs35565079; rs9990004; rs34986622; rs35245111; rs4688465; rs2218652; rs2040379; rs181005; rs9868595; rs13317696; rs9842782; rs34174974; rs34401538; rs9831418; rs33965820; rs34773072; rs35373770; rs11928502; rs13060732; rs34895617; rs9825246; rs2187634; rs6769291; rs11370683; rs13097091; rs2687154; rs180986; rs13081364; rs1735455; rs6806308; rs34700535; rs34070618; rs34673526; rs28783473; rs13083707; rs28418480; rs28448293; rs11344395; rs34686536; rs10707963; rs6775224; rs34478170; rs2594146; rs1735450; rs11272366; rs9878337; rs10568757; rs35343967; rs35359990; rs35787121; rs6801528; rs11425470; rs11915490; rs9990336; rs34287614; rs7649527; rs28884878; rs1716704; rs28491152; rs10576663; rs35911874; rs2856023; rs7629955; rs34252907; rs34739265; rs35788475; rs1823243; rs4020780; rs6773491; rs13086671; rs35863141; rs12492105; rs13070030; rs11720919; rs7625573; rs35858490; rs11472546; rs9813447; rs10653205; rs36128949; rs35501970; rs961997; rs13314035; rs2365486; rs2364294; rs9877613; rs9837041; rs35643303; rs35434242; rs13101168; rs35136364; rs34064157; rs36179040; rs180979; rs35008199; rs34162767; rs721206; rs13091994; rs10212384; rs12487887; rs10706478; rs35156110; rs13066650; rs1524017; rs12491230; rs11427587; rs35381011; rs35636925; rs2594131; rs11707631; rs2860193; rs28508111; rs35016129; rs569112; rs34022190; rs34897753; rs34099300; rs10626854; rs13067953; rs28658327; rs9819526; rs4129351; rs2682957; rs9829848; rs34824573; rs34335317; rs36180064; rs5849400; rs4474995; rs2856053; rs3037209; rs34348154; rs34903967; rs2682975; rs13072770; rs7433409; rs7649297; rs17063581; rs10533881; rs11401294; rs6775312; rs11425154; rs34515346; rs17063488; rs9858465; rs10704615; rs35873528; rs9812327; rs4688358; rs171352; rs9877087; rs34916589; rs11718094; rs34749460; rs9681765; rs9837018; rs9873789; rs34115573; rs35617200; rs34709345; rs6445199; rs2856051; rs35551227; rs6802461; rs241668; rs13065516; rs35908550; rs2855999; rs34811988; rs35386733; rs9820875; rs9850790; rs10621306; rs7431478; rs1839076; rs7372733; rs2856079; rs11715419; rs28478282; rs35883178; rs4688333; rs4020380; rs34418330; rs34956027; rs9833340; rs34525181; rs6780422; rs28525348; rs34032172; rs35502892; rs34559466; rs5012715; rs4688507; rs2856009; rs1735463; rs36004430; rs2856050; rs10704764; rs11130824; rs11925681; rs34455205; rs7617339; rs34572867; rs2682983; rs4021312; rs9835422; rs1055673; rs35250637; rs9826449; rs35348354; rs2105830; rs28816764; rs35919545; rs11282211; rs5849372; rs12054388; rs181007; rs28576434; rs34516750; rs13060811; rs2856073; rs1735442; rs35029951; rs4974242; rs4479544; rs2682934; rs11280805; rs2165043; rs2156976; rs10641935; rs10664594; rs11445450; rs13100037; rs180990; rs2226974; rs34618598; rs35744933; rs35401166; rs4599253; rs5849374; rs9829538; rs181000; rs34933857; rs34412023; rs9817744; rs34983593; rs9852481; rs28584187; rs1716716; rs34431077; rs13065530; rs9834789; rs2594235; rs6769615; rs36069838; rs4561778; rs7626938; rs34363503; rs9864174; rs7609788; rs241679; rs11355861; rs4688297; rs2594133; rs7641879; rs17063583; rs35834727; rs28748014; rs5849296; rs11359494; rs35873241; rs35487435; rs10575654; rs9836264; rs2856000; rs34401856; rs2118810; rs4974252; rs242188; rs11387609; rs10686970; rs28755000; rs17063650; rs13080777; rs4688338; rs35734369; rs11391400; rs12629280; rs13084385; rs9869679; rs9871663; rs28430306; rs34746589; rs4688354; rs2156971; rs4605538; rs2594241; rs12631103; rs34920274; rs4679551; rs9868796; rs10576295; rs7634630; rs34539792; rs35948190; rs13323714; rs28735912; rs5849405; rs34936297; rs34942224; rs35773630; rs7651656; rs34591582; rs28885672; rs1794073; rs13079703; rs34600947; rs9841737; rs11405504; rs4542972; rs11438531; rs36136303; rs28750168; rs180985; rs10619770; rs11710155; rs36022063; rs2885866; rs35689847; rs241666; rs10702654; rs28575473; rs1623711; rs35974843; rs13088864; rs5849379; rs11716189; rs34805544; rs35239751; rs9872213; rs34236976; rs10689165; rs6768510; rs2363671; rs10695073; rs1716750; rs34229498; rs11430868; rs34283247; rs6795921; rs4688469; rs28537075; rs9870929; rs9811948; rs28496326; rs35007610; rs35892825; rs10691156; rs11716726; rs2734362; rs35145550; rs3046744; rs11434661; rs11916130; rs2205354; rs11303821; rs11928556; rs12488246; rs36001340; rs9875360; rs34066354; rs35704934; rs11712204; rs35403191; rs9837499; rs35411656; rs7632898; rs2734364; rs1735451; rs10656054; rs5849398; rs2734349; rs6801067; rs9869618; rs34725164; rs28605691; rs765434; rs35675677; rs35681055; rs13086029; rs1716707; rs10670228; rs10663822; rs13319932; rs13087179; rs242185; rs34684512; rs13087014; rs9819916; rs35250444; rs35746862; rs17063529; rs34341542; rs6762023; rs7651928; rs10622214; rs6773927; rs2734412; rs34962341; rs35912845; rs13096705; rs5849377; rs34430551; rs28728310; rs34320797; rs35699949; rs1583702; rs9849983; rs727346; rs35696878; rs10703194; rs2594117; rs9810266; rs11425787; rs7618698; rs149288; rs2363682; rs35789205; rs34412484; rs2856035; rs11382712; rs13060457; rs34225061; rs34640191; rs34673542; rs11392485; rs34957475; rs35183529; rs35766255; rs28753768; rs2682938; rs10533880; rs13069537; rs10695129; rs979312; rs12632616; rs11348608; rs6766427; rs34832921; rs180981; rs35149801; rs9821492; rs36013056; rs10562060; rs10625111; rs2363676; rs34654439; rs9647383; rs13066763; rs2856007; rs34822388; rs36052683; rs34495897; rs2856078; rs1716712; rs34292145; rs34485211; rs35960525; rs13091058; rs3832204; rs35204675; rs10662568; rs11278628; rs2856013; rs35432601; rs2594120; rs34951126; rs2856049; rs13321408; rs35072941; rs3037275; rs6804992; rs12491542; rs181004; rs2205346; rs11462420; rs36063715; rs9828871; rs9856646; rs34723569; rs5849399; rs34396410; rs13066447; rs2859662; rs6766677; rs11293623; rs35245268; rs11365015; rs11328245; rs36117889; rs9820481; rs35254240; rs2856011; rs2250969; rs35650409; rs34552943; rs6777603; rs2856066; rs9874852; rs34620163; rs7617938; rs5849407; rs12632475; rs6782381; rs13090237; rs35799828; rs12639089; rs35064699; rs11714964; rs2594127; rs35631111; rs1569345; rs13315448; rs35303160; rs2364298; rs11708181; rs28649296; rs11439512; rs9829239; rs34095991; rs4688134; rs4501070; rs34590329; rs13323559; rs34483377; rs2736757; rs9830059; rs35348304; rs35927692; rs34446077; rs4131084; rs35173173; rs34399107; rs9830759; rs13086837; rs9713179; rs9830615; rs11706083; rs13323578; rs2856016; rs36081877; rs6793716; rs35800632; rs9851716; rs12629536; rs241680; rs1735474; rs36092451; rs34944499; rs35407960; rs13086900; rs13318799; rs28867979; rs1735446; rs34747779; rs4688292; rs7429202; rs2097245; rs33996943; rs9815870; rs35059482; rs35280964; rs1735465; rs35582986; rs28856691; rs2856019; rs34439911; rs11439537; rs10664035; rs35555910; rs4688194; rs12330455; rs6791869; rs28738855; rs12488069; rs34367227; rs34938634; rs11293951; rs4688379; rs2856020; rs34296525; rs1821944; rs34170228; rs6783289; rs34923529; rs9843764; rs35073498; rs6786603; rs35559858; rs34758574; rs35899453; rs13077540; rs9861349; rs2121854; rs34494286; rs17063907; rs11714472; rs11130828; rs2856054; rs35657114; rs35105245; rs13319364; rs5849392; rs34450737; rs34980096; rs13326349; rs10662562; rs4266142; rs2156970; rs12491643; rs10621225; rs33937609; rs34103921; rs17063575; rs13068391; rs1716746; rs35995776; rs4472047; rs10574931; rs9809726; rs5849406; rs13321403; rs1524018; rs28555532; rs35002792; rs34629540; rs34490290; rs181006; rs9825775; rs28868951; rs10546180; rs34055249; rs35694637; rs17031631; rs13322395; rs181009; rs11130786; rs5849375; rs2363673; rs28830835; rs17063926; rs35183064; rs10707795; rs34385578; rs28873069; rs13086117; rs11344435; rs35426147; rs7614509; rs11336775; rs2594168; rs6802143; rs34818520; rs34911543; rs34979014; rs1540264; rs1965144; rs36196206; rs28583267; rs7648601; rs241676; rs2594259; rs9869632; rs34972944; rs741890; rs11710325; rs2856069; rs6762101; rs1130978; rs36105469; rs35035467; rs5029084; rs35505617; rs28666776; rs7622067; rs34827609; rs6793331; rs2142297; rs35650631; rs6794099; rs36021215; rs35869445; rs7433194; rs34345610; rs34891541; rs180989; rs34782322; rs36152415; rs34095404; rs35363602; rs9815205; rs13087718; rs36086848; rs10621855; rs151744; rs2056834; rs6801372; rs28482301; rs2856046; rs10656019; rs35509555; rs36059042; rs34218648; rs34306015; rs2682953; rs6414611; rs28560409; rs6446177; rs2083266; rs28506184; rs11446370; rs9814803; rs2856064; rs13073765; rs11714170; rs34982675; rs35545949; rs28707531; rs2682941; rs35221092; rs35828098; rs35312000; rs10703190; rs9870453; rs35455823; rs13094274; rs9853325; rs2365487; rs2594255; rs2682972; rs34451030; rs10653206; rs11716097; rs9850949; rs1823244; rs11438506; rs11387424; rs6794021; rs13099255; rs11317231; rs5849385; rs4974238; rs9820935; rs9869626; rs1125285; rs12330305; rs2856052; rs13098867; rs35000370; rs17689244; rs13327793; rs35916380; rs28715912; rs11425572; rs1630653; rs2594128; rs13096643; rs1716754; rs2364296; rs2364299; rs35570778; rs36077598; rs9845813; rs35009509; rs6804386; rs4688336; rs13073732; rs1319373; rs2736735; rs34706798; rs35935535; rs13075178; rs7429700; rs13068091; rs35626086; rs13073213; rs12490432; rs12489327; rs2682958; rs28449422; rs2165042; rs11717185; rs9813137; rs34614721; rs1794074; rs5849395; rs34126057; rs9815486; rs34153115; rs35195170; rs5849394; rs5849408; rs11130832; rs6762109; rs7432473; rs10577229; rs34615883; rs6772343; rs34268864; rs34327357; rs6795548; rs5849380; rs34918994; rs35581450; rs5849401; rs35398590; rs10662932; rs34958501; rs9754560; rs4991694; rs13080382; rs6770111; rs28626240; rs13067776; rs7622829; rs4688359; rs9851860; rs1716727; rs34696094; rs2856024; rs11717364; rs34708949; rs4508731; rs180996; rs2682935; rs10575380; rs7651882; rs6773042; rs34260769; rs34427728; rs34909377; rs7356048; rs1716715; rs7620934; rs7651100; rs4596101; rs17063570; rs9833598; rs11351593; rs9823985; rs2856062; rs7431422; rs34005146; rs34647274; rs35971675; rs36191215; rs34954847; rs28705379; rs9854994; rs10577548; rs35786965; rs2056565; rs2682964; rs35708329; rs35713747; rs35035484; rs35950756; rs35979959; rs6779695; rs35683398; rs9827429; rs3952592; rs13068405; rs9809084; rs2855997; rs35666586; rs35256219; rs10588513; rs11370343; rs9849480; rs11359451; rs181008; rs1716703; rs2856060; rs13068446; rs36143644; rs11130808; rs34537487; rs35281998; rs35808939; rs12629072; rs9990003; rs34909493; rs11297542; rs34416041; rs11430739; rs34066804; rs2682955; rs28414779; rs13060497; rs2594124; rs5849373; rs28702371; rs35722852; rs34665072; rs36197522; rs180978; rs35247212; rs11396147; rs2594115; rs33987194; rs10702598; rs9853572; rs34100153; rs28726379; rs28367502; rs9873803; rs13098545; rs7638374; rs2856031; rs35809328; rs35558909; rs35937942; rs10596787; rs35438702; rs1272210; rs6446137; rs6793381; rs2886247; rs11130778; rs34057836; rs12635701; rs765271; rs2118814; rs9876426; rs35320264; rs36176490; rs9868561; rs34371463; rs1371092; rs34287266; rs3046704; rs6782546; rs35795196; rs4021313; rs35443634; rs6764919; rs35357854; rs4688355; rs33915401; rs4290800; rs35254708; rs13099227; rs2594263; rs11318342; rs34320086; rs11714429; rs10620746; rs180984; rs28790402; rs34316880; rs34918702; rs11337159; rs2856012; rs35595048; rs10576845; rs35198002; rs34779032; rs7638316; rs13088848; rs13074216; rs1735456; rs34606948; rs4679550; rs11456762; rs2856001; rs28472466; rs2594118; rs35013109; rs11281807; rs10706485; rs36033536; rs34430584; rs2594256; rs35938215; rs12487490; rs35059096; rs36140477; rs9862956; rs35047197; rs12492454; rs12494251; rs35534615; rs10562335; rs35585287; rs34163614; rs34696953; rs13323742; rs2594126; rs241667; rs9833028; rs4605537; rs34259904; rs35424414; rs6780451; rs9838956; rs1156587; rs5849402; rs13073737; rs34657304; rs2682959; rs35814395; rs11341318; rs180991; rs34255725; rs4501071; rs2856074; rs13073974; rs34294936; rs9864593; rs35858922; rs2226975; rs2682939; rs4974237; rs9814914; rs35308129; rs13327442; rs35910658; rs5012716; rs4378928; rs34363177; rs2856010; rs9808941; rs36184836; rs11434662; rs5849397; rs9842786; rs2097246; rs34609167; rs35037932; rs13326903; rs34821431; rs2734348; rs35121432; rs34393705; rs4991695; rs9755626; rs35010280; rs9826292; rs11379500; rs34253135; rs9839366; rs11278323; rs34110394; rs11918956; rs35294523; rs35530282; rs3037240; rs34943127; rs34565354; rs13087175; rs4688334; rs3037212; rs35637630; rs34683848; rs35361297; rs34501669; rs34515056; rs35784749; rs2099668; rs28703924; rs28766341; rs35169228; rs35299226; rs36213301; rs10711619; rs5849404; rs7640548; rs34929328; rs13094360; rs9866819; rs2859794; rs35269423; rs2682933; rs34470378; rs34201817; rs28680515; rs10616921; rs10620327; rs9839960; rs28660311; rs34914862; rs33939225; rs35479217; rs35166731; rs35242657; rs35093010; rs35481618; rs11414933; rs1447913; rs1554600; rs5849390; rs34731310; rs28856934; rs11456269; rs1735447; rs17063530; rs10620887; rs6770159; rs13096774; rs2682947; rs2226973; rs4458366; rs12632940; rs2859663; rs11130787; rs17031623; rs10586440; rs1735459; rs28845848; rs2856070; rs11279188; rs28768455; rs34338152; rs9836556; rs11711795; rs9790016; rs34116159; rs6797158; rs5849297; rs2363668; rs35353442; rs11297153; rs180980; rs9833603; rs2856014; rs9873238; rs28604875; rs17063930; rs9871498; rs34511828; rs13091033; rs35222818; rs2251572; rs11342311; rs35110807; rs2156972; rs13100732; rs12632429; rs2859552; rs34220367; rs13323863; rs35478265; rs2142299; rs4524236; rs13076525; rs13082796; rs36036534; rs28678424; rs13091132; rs2594116; rs9654008; rs2187635; rs9754679; rs34136528; rs35115252; rs2594121; rs11391685; rs9882869; rs9830971; rs6786356; rs34247297; rs10530745; rs7356063; rs35802292; rs35408658; rs2856065; rs3074256; rs36089312; rs2363675; rs9822578; rs28590688; rs35313207; rs11921965; rs11710373; rs11446362; rs10617295; rs28708759; rs34243612; rs10653812; rs35675876; rs4292193; rs35881955; rs35082108; rs10707340; rs13076939; rs13083049; rs34111196; rs35599254; rs9869553; rs9834653; rs34473180; rs4519689; rs2166813; rs13084713; rs7646798; rs35033038; rs35673396; rs13060670; rs11391529; rs28459374; rs9883990; rs2736751; rs10637926; rs6774890; rs9870642; rs1447915; rs241696; rs5849389; rs35527583; rs35527648; rs241678; rs35436653; rs5849391; rs28819530; rs11130829; rs13096718; rs9869204; rs34126858; rs35161045; rs13061677; rs13084163; rs35731128; rs11459342; rs11283815; rs10622213; rs11426035; rs4688207; rs3054020; rs11710413; rs3037236; rs2734346; rs34895944; rs2734411; rs6806749; rs11358547; rs2856022; rs1716708; rs9827853; rs34970155; rs35166973; rs9868836; rs11369125; rs9810275; rs35217802; rs34790838; rs9837071; rs2682937; rs1371094; rs34802371; rs35941471; rs1735441; rs5849382; rs12107612; rs13060737; rs6777395; rs11923398; rs12493853; rs35557543; rs34423892; rs11328983; rs35270643; rs11378635; rs7433800; rs11711494; rs5849384; rs35513480; rs35140567; rs1597100; rs35454787; rs35093806; rs34374881; rs35353184; rs5849378; rs13096315; rs28818630; rs12639018; rs6784990; rs35388697; rs2682932; rs2205355; rs107342; rs1267318; rs35129876; rs35300348; rs35451480; rs35996920; rs2682940; rs4688337; rs35825854; rs36064104; rs12637231; rs34327253; rs34499190; rs13098952; rs2856075; rs13083701; rs33999627; rs9819332; rs13316031; rs694338; rs34967661; rs680467; rs9809946; rs36012115; rs28762764; rs34879293; rs520737; rs10709109; rs151745; rs909110; rs635904; rs7624854; rs212022; rs34373315; rs190892; rs34579384; rs10222574; rs598508; rs35066861; rs35912433; rs36175120; rs28373656; rs13079397; rs34197269; rs9682326; rs35207762; rs192667; rs28538294; rs13095634; rs6764821; rs2736828; rs1474308; rs11400200; rs35231588; rs34005341; rs9829898; rs35397730; rs2629892; rs11313024; rs36014753; rs427263; rs1485715; rs2362236; rs11392233; rs5849314; rs34560933; rs5849355; rs10702893; rs13088666; rs10621041; rs2630169; rs13088034; rs11456216; rs13088055; rs35693946; rs33978427; rs36023952; rs17062655; rs2687187; rs35692822; rs35297861; rs9869351; rs34140915; rs6803420; rs9851823; rs13084152; rs35830544; rs11437244; rs2178928; rs12172955; rs35082528; rs9844975; rs34244389; rs598164; rs11401440; rs34108188; rs5849335; rs2594247; rs10678623; rs2687174; rs10622117; rs1385818; rs6772276; rs9851678; rs10662862; rs34867216; rs2736774; rs1825632; rs4019407; rs9856764; rs4020068; rs2594267; rs2629901; rs931319; rs34420724; rs33979600; rs35924713; rs695074; rs34529886; rs28563777; rs35569650; rs9829103; rs13094765; rs28552937; rs5849367; rs10648497; rs680884; rs9968157; rs11337847; rs2630155; rs6765281; rs241703; rs5849329; rs5849364; rs11414516; rs35603990; rs35010131; rs4257500; rs550271; rs28680683; rs4679649; rs35866265; rs1683642; rs658563; rs36206456; rs10599323; rs34629260; rs1630608; rs35658638; rs35282656; rs502074; rs3047601; rs13316266; rs4679543; rs34684433; rs34388117; rs35734112; rs12630039; rs6773712; rs2630208; rs11353060; rs28472615; rs644301; rs2594240; rs2223087; rs4679514; rs2629881; rs2142304; rs2166791; rs34420878; rs570987; rs398084; rs11435467; rs994931; rs5849309; rs936822; rs6801035; rs11456924; rs11307941; rs13321394; rs17340442; rs7432575; rs34059157; rs6771497; rs11294820; rs17062681; rs11304366; rs35907783; rs9812818; rs558799; rs35068382; rs643121; rs511829; rs34077326; rs33926480; rs1817615; rs11394238; rs34808738; rs35607317; rs11408566; rs2630197; rs2629878; rs4083119; rs11339957; rs802773; rs11369122; rs11459796; rs515208; rs13095234; rs10612042; rs6763702; rs13070067; rs34836199; rs655196; rs242215; rs599423; rs11292700; rs11291510; rs4679506; rs13092827; rs10702128; rs34543324; rs13091891; rs1485903; rs1719827; rs6802911; rs7641733; rs34335070; rs623612; rs34152522; rs10154943; rs3856661; rs242229; rs17062548; rs651665; rs6791382; rs34217736; rs600427; rs34276482; rs34267930; rs13095796; rs11298082; rs34606853; rs2734407; rs11401556; rs10702694; rs35536041; rs11452248; rs10716077; rs660097; rs11357385; rs11391965; rs1319341; rs9867252; rs35057861; rs34190482; rs570366; rs34087679; rs242190; rs34118312; rs35755790; rs3060314; rs674930; rs190891; rs2630160; rs34284077; rs11712298; rs28579930; rs34476489; rs655222; rs34748094; rs3112504; rs7636540; rs13085067; rs35746727; rs17062213; rs35509233; rs6762036; rs28735681; rs383180; rs35823785; rs35781602; rs41397044; rs9852879; rs34819971; rs36022402; rs970883; rs11302357; rs34984537; rs36145405; rs2687166; rs35174234; rs11300360; rs2687173; rs4441611; rs28387016; rs212056; rs13060660; rs560357; rs6769523; rs2611402; rs10540921; rs35153236; rs35959468; rs629627; rs9872805; rs2197750; rs13092798; rs35304624; rs2687901; rs391000; rs35840730; rs7612775; rs212026; rs10576463; rs35992738; rs2687188; rs9874226; rs35289739; rs2594234; rs13099360; rs13093788; rs5849328; rs6791176; rs34574670; rs17062607; rs17062298; rs13088637; rs9834305; rs7636133; rs35543838; rs41460748; rs34429390; rs11130758; rs35402912; rs2630151; rs11296303; rs475675; rs242210; rs34221661; rs35803418; rs3894422; rs10621942; rs34459199; rs34351487; rs34107042; rs604791; rs10576674; rs2605446; rs11457865; rs33935811; rs172455; rs12635180; rs1057503; rs11441945; rs34590310; rs34532632; rs35825158; rs11294007; rs588866; rs35651687; rs7622342; rs2687156; rs1964583; rs34531974; rs35240844; rs35714610; rs494368; rs13327466; rs802776; rs17298728; rs2450224; rs6798836; rs7610776; rs2630158; rs33937348; rs9857422; rs5849361; rs11299448; rs2687898; rs12633772; rs400030; rs10621786; rs570672; rs10620271; rs3894423; rs11420708; rs35015506; rs9846004; rs5849359; rs41505547; rs3836263; rs529626; rs35618987; rs35668749; rs5849339; rs13077273; rs34333733; rs9843458; rs442760; rs11385769; rs2611407; rs35245215; rs35428356; rs13092800; rs5849303; rs213331; rs5849305; rs5849344; rs34577004; rs34290422; rs9880785; rs1126268; rs11308405; rs10672242; rs2629888; rs17256383; rs35826777; rs34377485; rs10556979; rs9809679; rs35165735; rs28699278; rs35565582; rs10575548; rs17362276; rs10621464; rs2594237; rs34476175; rs34769124; rs9836175; rs213425; rs6789228; rs35034017; rs35438812; rs414751; rs1474524; rs4124060; rs34902177; rs17376950; rs34892552; rs35957311; rs11375265; rs439531; rs2629885; rs9814126; rs34919399; rs12492752; rs35546407; rs213334; rs901166; rs12163553; rs4679632; rs35294469; rs36031158; rs35370996; rs34436887; rs213417; rs213296; rs10553757; rs440337; rs7650713; rs13067663; rs28532353; rs5849319; rs36087881; rs10702961; rs35230709; rs34939144; rs7638538; rs28590559; rs35022605; rs6803991; rs35700900; rs167160; rs2611418; rs34922025; rs13068840; rs1683637; rs2885637; rs4446177; rs11299074; rs12106838; rs3100804; rs10716252; rs34559994; rs550237; rs3060310; rs1817616; rs11388787; rs10585061; rs17061245; rs34503855; rs5849311; rs35288900; rs2734382; rs2630171; rs34068812; rs11714457; rs34970137; rs213314; rs28716988; rs1683635; rs41384746; rs34816043; rs35688444; rs5849352; rs409432; rs671920; rs11369368; rs35303895; rs1038500; rs35443610; rs2736809; rs2630193; rs34668808; rs35773776; rs9878244; rs28610194; rs11293631; rs4021919; rs4021920; rs5849370; rs34184253; rs6147838; rs2736799; rs9876439; rs11436091; rs35417374; rs2472012; rs242220; rs34262673; rs34837102; rs35033374; rs11349315; rs34196742; rs9809756; rs615501; rs213362; rs10662742; rs510015; rs13065824; rs35019677; rs34059017; rs34113926; rs11425921; rs728518; rs2687190; rs558732; rs35928440; rs34956621; rs13085634; rs7630676; rs34862516; rs11918011; rs13321569; rs12053887; rs11359834; rs2630192; rs2629900; rs35292125; rs6446158; rs9858300; rs17062653; rs35909447; rs695144; rs5015378; rs11708941; rs34137642; rs34400019; rs1983425; rs2736813; rs1666065; rs525709; rs2734353; rs2736775; rs2594238; rs28490895; rs11331230; rs34440332; rs34775476; rs13088669; rs34272009; rs3112501; rs36123588; rs35975975; rs9865860; rs5742127; rs9832932; rs35666962; rs1628506; rs33954362; rs2734410; rs936821; rs34893282; rs2220240; rs35745922; rs10637442; rs2450225; rs4679636; rs34032310; rs2064015; rs901164; rs2450227; rs10662718; rs35898751; rs650697; rs11720828; rs10702573; rs4024132; rs35067946; rs5849315; rs2687164; rs34420035; rs35867997; rs34538996; rs378177; rs34336496; rs36019591; rs167159; rs242228; rs3052772; rs35122656; rs608341; rs4022385; rs34180760; rs1318329; rs34877048; rs4679540; rs10646479; rs3112503; rs35724062; rs11360780; rs34995397; rs406364; rs34732137; rs34673563; rs6790458; rs242219; rs11328401; rs12635117; rs35605213; rs1485726; rs592763; rs17062490; rs13313997; rs3891656; rs2362883; rs17322285; rs35717946; rs1485716; rs12107679; rs404404; rs10680391; rs34974981; rs5849354; rs17061422; rs1683348; rs34970290; rs11313847; rs1111567; rs35283824; rs1485722; rs10619871; rs2605440; rs394261; rs2736822; rs11433582; rs11391601; rs9831468; rs2687186; rs6785349; rs242191; rs6446124; rs13096724; rs9857445; rs36067393; rs1825631; rs35007946; rs10702693; rs35601814; rs2366962; rs654791; rs34307116; rs34886888; rs11360937; rs3856660; rs10716376; rs35209666; rs41276483; rs2101322; rs13069875; rs623645; rs2472009; rs41358048; rs663274; rs9829427; rs34797911; rs3856657; rs3100801; rs2736768; rs9819123; rs11368905; rs2687172; rs10527581; rs10633871; rs5849347; rs41532848; rs34615685; rs615275; rs666445; rs5849343; rs35531886; rs9881435; rs34318256; rs35933553; rs5849340; rs34783282; rs11288782; rs10718005; rs34136457; rs620783; rs13076427; rs6765946; rs1613046; rs410775; rs11298083; rs13093024; rs13081317; rs11345934; rs666083; rs34595821; rs9879525; rs35739707; rs644087; rs34966988; rs11293550; rs11456344; rs151748; rs13095523; rs35739482; rs11418936; rs447643; rs11280475; rs34479858; rs6762271; rs213413; rs5849351; rs9824749; rs35830310; rs4395357; rs35366562; rs17061294; rs3772449; rs17062091; rs17062818; rs10663373; rs11715784; rs28451006; rs36117888; rs693495; rs441410; rs13087174; rs6787887; rs34596023; rs34361915; rs28538229; rs9682843; rs5849368; rs10709070; rs34917954; rs10597353; rs34858537; rs7647647; rs3836262; rs28566813; rs583560; rs3047602; rs28511287; rs3047575; rs11304071; rs35278876; rs34412225; rs9823629; rs11422969; rs34390680; rs9864038; rs2734388; rs34692050; rs7649319; rs28538005; rs11288129; rs35203172; rs17400606; rs17062219; rs9839717; rs34285374; rs34858155; rs4019408; rs7349556; rs4679536; rs2687905; rs35316814; rs17378007; rs35211850; rs5849322; rs10653458; rs35599982; rs9838029; rs3836266; rs6809898; rs213303; rs13061151; rs637319; rs13066026; rs34901097; rs2173055; rs35968635; rs34074007; rs35450027; rs11328658; rs35378512; rs12634693; rs3894421; rs386599; rs35707726; rs241686; rs9823263; rs586389; rs35606091; rs36008750; rs33913871; rs34382742; rs35302096; rs413761; rs35062001; rs35514185; rs4024128; rs2630152; rs2594242; rs28588365; rs35941668; rs652508; rs28481934; rs2362894; rs35674510; rs2687155; rs35014839; rs5849362; rs34717494; rs35450706; rs10688853; rs9819602; rs11369408; rs17062781; rs34687640; rs3836265; rs9868436; rs3821483; rs35599458; rs9833497; rs35653867; rs17061223; rs35401835; rs12630992; rs7639761; rs17062038; rs35704552; rs533740; rs35397711; rs35500094; rs10609396; rs13089872; rs34424783; rs2605439; rs12108078; rs35601823; rs36022455; rs13088038; rs2630159; rs6794069; rs17061347; rs11276616; rs599589; rs34975359; rs12492513; rs11456777; rs11715442; rs12487808; rs242240; rs484579; rs2687180; rs2611412; rs35486781; rs35318702; rs6766022; rs663874; rs17063054; rs9841213; rs7646436; rs35711659; rs11455284; rs213422; rs6782781; rs3772478; rs35592181; rs594055; rs36105967; rs35869378; rs12107577; rs35324781; rs1485902; rs13085511; rs35861160; rs35693379; rs35899156; rs9874243; rs7614321; rs598616; rs10561160; rs9874381; rs34661857; rs35270205; rs11305354; rs34350602; rs212012; rs599459; rs2734384; rs650247; rs6794136; rs5849332; rs242218; rs172491; rs13077792; rs12632279; rs34417630; rs35890518; rs2223085; rs11292764; rs13066659; rs11429625; rs11359347; rs9682165; rs35901722; rs13316429; rs36005132; rs35598923; rs582313; rs35231061; rs13076244; rs33999758; rs415353; rs12494457; rs11278637; rs11717308; rs35216768; rs35387531; rs41347345; rs9869159; rs3905395; rs9856850; rs34028777; rs650696; rs9810924; rs34377896; rs34518686; rs34691260; rs17063076; rs7647341; rs28562950; rs5849312; rs36102608; rs28459515; rs34264470; rs398107; rs35620788; rs7647522; rs608981; rs1813833; rs580362; rs1683636; rs9882591; rs4124059; rs5849371; rs11375093; rs6769239; rs3821486; rs11360020; rs35256799; rs34226567; rs12491492; rs34752418; rs9838705; rs11410877; rs2736798; rs11425928; rs10428261; rs979986; rs11715167; rs415879; rs34971963; rs2594262; rs36035542; rs10154941; rs17062138; rs34176966; rs11385307; rs11437945; rs688567; rs621837; rs34737256; rs34744520; rs35212164; rs5849302; rs34603508; rs3943174; rs34945868; rs13069932; rs34681331; rs35296431; rs34872452; rs10663256; rs35848405; rs9846543; rs11317328; rs35287454; rs10470624; rs28452132; rs4021917; rs13068123; rs28644278; rs35158575; rs5849320; rs35247746; rs10539229; rs10703110; rs12054281; rs6803872; rs13087855; rs34384407; rs34034432; rs6446106; rs679085; rs17062253; rs11301238; rs10703540; rs13079850; rs34559077; rs1719824; rs687447; rs11446703; rs11719706; rs34884636; rs242223; rs11293630; rs11329851; rs212002; rs34944550; rs11293701; rs17062486; rs671754; rs11293601; rs10585949; rs11445812; rs6794044; rs35438044; rs3772457; rs34724960; rs2736800; rs34863679; rs35996382; rs1882736; rs3772461; rs13080521; rs10553845; rs664722; rs35417967; rs213330; rs213393; rs9827718; rs7613262; rs17311592; rs35879691; rs406667; rs9813260; rs11400256; rs35789112; rs12330818; rs213332; rs34397808; rs28602951; rs9858462; rs17062817; rs28594929; rs670885; rs34453102; rs28378638; rs4024133; rs35699027; rs151736; rs9817511; rs34832555; rs3060316; rs6797791; rs36002497; rs11288598; rs9837685; rs418428; rs1485720; rs34895232; rs7650092; rs34687143; rs9870841; rs36071604; rs17062124; rs11711514; rs169842; rs9827078; rs35103208; rs241699; rs34668248; rs28557335; rs670469; rs35104072; rs36095441; rs10662436; rs36125400; rs1580456; rs4465902; rs9878319; rs13076237; rs13327071; rs35178232; rs2630188; rs5849326; rs814296; rs694466; rs34992762; rs11347048; rs5849317; rs9861642; rs13325477; rs9812351; rs2611405; rs35787292; rs550738; rs35251804; rs34671935; rs4453800; rs2132607; rs35209040; rs33969323; rs11425227; rs10691937; rs11715317; rs35335356; rs13060801; rs12492537; rs34147843; rs6789385; rs11289210; rs34594149; rs5849336; rs34787563; rs2205039; rs2630162; rs34006407; rs12487671; rs17062571; rs6809115; rs34375145; rs669497; rs213293; rs11293551; rs11323557; rs3075168; rs35015822; rs186060; rs242227; rs4679504; rs13096007; rs28385511; rs34491079; rs34254319; rs34103158; rs35629879; rs6784116; rs9852972; rs34712565; rs34816113; rs34791252; rs1485905; rs28397568; rs212024; rs974513; rs3772492; rs11456264; rs3884255; rs11288438; rs34499848; rs35169596; rs9880557; rs1666095; rs5849357; rs3102827; rs212021; rs599542; rs6791372; rs34488580; rs9850880; rs35731034; rs427057; rs9799361; rs35102526; rs34555513; rs34907688; rs35447167; rs6788207; rs410322; rs35402597; rs34754005; rs11391580; rs6778314; rs4679646; rs34685557; rs35147013; rs2885642; rs17061527; rs3112502; rs5849316; rs901163; rs34768947; rs28704738; rs34237399; rs36107455; rs409769; rs9871322; rs34680230; rs35560846; rs34095596; rs35782604; rs1683343; rs13324099; rs6801047; rs9827193; rs2594249; rs11457779; rs11719596; rs34781790; rs9872055; rs2362882; rs2362897; rs11369935; rs10719245; rs2736770; rs2220239; rs7616889; rs35199648; rs11408869; rs11298084; rs10604761; rs9874945; rs7616984; rs10718750; rs34471619; rs9835872; rs35776137; rs7629735; rs2629890; rs7647658; rs2687904; rs10715035; rs431150; rs28582870; rs34741389; rs17062836; rs17061437; rs680939; rs596938; rs6780851; rs176921; rs11359385; rs35037895; rs3772456; rs213378; rs3112500; rs35480699; rs35966319; rs35722700; rs35571653; rs10553211; rs11347167; rs11324509; rs1022444; rs28607768; rs13060974; rs35363213; rs34704516; rs35096012; rs6793899; rs2734386; rs6147840; rs1485721; rs35598501; rs3060261; rs35602079; rs35682010; rs679533; rs5849369; rs608878; rs41355450; rs9818283; rs35625793; rs10688852; rs34462181; rs1683644; rs370716; rs5849342; rs35153948; rs6769666; rs3060269; rs6766857; rs182417; rs2687896; rs34364126; rs12106780; rs35485080; rs35501653; rs12490488; rs13080038; rs9862809; rs686915; rs2734406; rs2736776; rs41495354; rs660050; rs10565469; rs34187428; rs2630195; rs13318262; rs5849349; rs3845975; rs1683355; rs13073897; rs35803265; rs34222091; rs5849350; rs9825408; rs9833268; rs608935; rs17062820; rs34100509; rs11921987; rs28652838; rs10539228; rs13065959; rs1485901; rs213403; rs125635; rs35675156; rs213397; rs35148673; rs13434176; rs7632624; rs7648302; rs35818352; rs1719825; rs694462; rs1564913; rs2885641; rs9837222; rs10557569; rs35411457; rs7634421; rs1566057; rs10621462; rs2605433; rs6446108; rs13066298; rs2734385; rs188398; rs17062625; rs5849333; rs9838465; rs10596417; rs12107346; rs13066009; rs9864838; rs35576259; rs7638262; rs35317846; rs657207; rs11293702; rs13092735; rs6446091; rs1125547; rs34558815; rs35241371; rs35086063; rs34937181; rs2629887; rs1612985; rs11440050; rs28895693; rs35191236; rs35842023; rs242173; rs13318597; rs35226385; rs2362887; rs36039530; rs9855887; rs35454666; rs1016448; rs11425296; rs2687171; rs34222977; rs34131703; rs33984761; rs33921357; rs34251639; rs34352051; rs35596941; rs35154871; rs35168480; rs2734409; rs936824; rs35011630; rs599096; rs1683639; rs992999; rs41313173; rs3100802; rs11411394; rs34116820; rs3856666; rs1352023; rs9876202; rs10575967; rs34836848; rs1390764; rs7432041; rs28369447; rs2687160; rs3836264; rs11130788; rs2361334; rs453526; rs13315124; rs4679509; rs34717174; rs35840648; rs34542104; rs183595; rs901168; rs4234287; rs6800898; rs6804813; rs9844452; rs28584323; rs34443383; rs34908488; rs11293904; rs36087359; rs34261055; rs34372764; rs36048815; rs1719823; rs10575278; rs10620609; rs241690; rs10621266; rs34865159; rs4257502; rs177035; rs3112506; rs34891258; rs184149; rs3060319; rs36017586; rs750794; rs2687903; rs4020064; rs9823066; rs13092858; rs2034336; rs372819; rs11432014; rs36106720; rs2605438; rs17340935; rs13089005; rs4428132; rs4679532; rs7629854; rs9872043; rs17063118; rs35124652; rs1960248; rs678729; rs34721052; rs35237584; rs186120; rs10619441; rs34655159; rs10574873; rs10691217; rs35461722; rs9869448; rs181448; rs13091743; rs17061587; rs17062694; rs212005; rs13317216; rs615143; rs5849330; rs17061447; rs4679633; rs2736811; rs10617567; rs12494254; rs35203627; rs242217; rs10642737; rs2629898; rs35487806; rs35755244; rs9847682; rs35342045; rs35171599; rs11721192; rs11328477; rs664695; rs7622712; rs11328478; rs41455050; rs35144644; rs7630156; rs2885253; rs1683643; rs11315084; rs11390620; rs9859075; rs11715794; rs7623812; rs17061913; rs34291859; rs662836; rs10048930; rs10155038; rs7433715; rs5007870; rs3894425; rs11441829; rs11293926; rs213360; rs1843398; rs694089; rs35507066; rs17310854; rs6794630; rs34836495; rs10575196; rs35667740; rs2091956; rs11346328; rs3836261; rs10662971; rs13079963; rs35203845; rs11344854; rs35840475; rs35289918; rs682689; rs35286558; rs409440; rs35122696; rs34220971; rs11288556; rs35512291; rs34764324; rs635527; rs505355; rs9843529; rs35931298; rs171353; rs35183377; rs1905941; rs13094560; rs17062857; rs17312006; rs9843548; rs2450226; rs2594271; rs35182472; rs5849365; rs13070077; rs393749; rs13101019; rs616604; rs28444511; rs34260904; rs13092255; rs28473445; rs11711739; rs6147839; rs13322831; rs35249308; rs3772469; rs1683641; rs17377293; rs10613771; rs11359384; rs7621737; rs4626048; rs3772455; rs5849337; rs2630163; rs34397608; rs665161; rs36082003; rs7632784; rs17363144; rs13061337; rs11926900; rs169916; rs576299; rs35167546; rs2687184; rs11922149; rs33997839; rs34613417; rs7648721; rs34774265; rs1882737; rs11368244; rs35313787; rs17062229; rs34381141; rs9815504; rs9838914; rs3821481; rs11411678; rs34126302; rs9814255; rs592876; rs28583724; rs11352722; rs5849300; rs9831864; rs35797840; rs9853585; rs492530; rs11708143; rs34195406; rs17298532; rs4597671; rs34480512; rs213292; rs11425767; rs34512636; rs11373882; rs34511232; rs10574937; rs12496431; rs13069732; rs11288370; rs679107; rs34034610; rs9859836; rs34274889; rs34330024; rs213419; rs10704758; rs13062945; rs28857786; rs34074099; rs6786852; rs4679534; rs6772747; rs34697759; rs35284351; rs7614891; rs5849366; rs34365876; rs509409; rs5849345; rs423910; rs242221; rs11403324; rs11362725; rs6779716; rs35534111; rs34862093; rs639705; rs34648748; rs4465903; rs2736797; rs13092997; rs34502195; rs35494038; rs35546821; rs13080137; rs11706993; rs597790; rs213312; rs11337340; rs13076409; rs6781046; rs34935769; rs35117438; rs13098599; rs34024916; rs34894656; rs2630142; rs11453296; rs35799137; rs5849356; rs9856748; rs7636213; rs7628285; rs7628136; rs11280943; rs34927902; rs5849307; rs909111; rs13069384; rs17062066; rs2630209; rs11371698; rs9820577; rs35607543; rs658725; rs35450604; rs10621849; rs35657144; rs2472011; rs901167; rs11324331; rs13088031; rs17062762; rs35488359; rs13060426; rs2594270; rs17062584; rs4093061; rs35917078; rs10662268; rs28494615; rs35246442; rs2736820; rs34799137; rs2611406; rs34256222; rs4021916; rs213379; rs10714504; rs35138137; rs35496987; rs35748189; rs35011379; rs1967641; rs17374699; rs35044128; rs4679525; rs213372; rs1882902; rs13070073; rs34918586; rs35552116; rs9881953; rs2734381; rs36036988; rs4019410; rs17062788; rs9842228; rs34593763; rs35350097; rs35345892; rs5849324; rs2736815; rs2687175; rs241689; rs242216; rs192675; rs437784; rs11310399; rs9867334; rs35849740; rs482814; rs11915829; rs17062710; rs17062463; rs34796045; rs35693926; rs190890; rs2734405; rs1719826; rs13060999; rs7616516; rs5849363; rs241702; rs439788; rs438501; rs17062052; rs34914890; rs11332615; rs17062068; rs35184553; rs9862243; rs34443264; rs3037458; rs10683236; rs35095248; rs242200; rs34893205; rs35532909; rs35916775; rs9824052; rs3887229; rs13077292; rs11339166; rs35332698; rs9809998; rs34810460; rs36032107; rs6767414; rs12486475; rs9882855; rs9863027; rs35775328; rs2736829; rs28472960; rs36203945; rs813608; rs34008895; rs11371406; rs4024134; rs35192595; rs17062536; rs13094466; rs35465254; rs190899; rs34648704; rs9828120; rs41347853; rs2046456; rs35740143; rs2736771; rs4679513; rs621855; rs13060988; rs34564498; rs441395; rs629300; rs10656986; rs17061940; rs4365581; rs35379090; rs13325133; rs410326; rs13061330; rs13314418; rs10695874; rs13070043; rs9847591; rs694423; rs35909623; rs13093023; rs35058364; rs35536483; rs587775; rs35953173; rs6782693; rs17063381; rs36075870; rs5849334; rs2734360; rs694576; rs1485714; rs10548266; rs10662389; rs35561334; rs6650906; rs10713144; rs35196912; rs13063683; rs11438598; rs34413493; rs454914; rs212035; rs582805; rs36223393; rs5849310; rs509412; rs672759; rs11458053; rs34925009; rs2630146; rs607731; rs35122152; rs35774308; rs35191621; rs2362239; rs34023165; rs242199; rs34269369; rs7628257; rs11305308; rs12107521; rs13088505; rs35343343; rs1817617; rs3102826; rs7626705; rs28495306; rs2886820; rs13076222; rs34144150; rs34536694; rs3100803; rs651177; rs35881306; rs2367088; rs2734408; rs12629645; rs34914689; rs11441692; rs528473; rs1683638; rs35612371; rs11440270; rs33987270; rs570702; rs17062204; rs13062539; rs34278984; rs7427388; rs35825465; rs35886433; rs405371; rs612707; rs34539132; rs2450165; rs35511149; rs9826481; rs35717439; rs9826192; rs2450223; rs4622857; rs2367084; rs41467656; rs34884909; rs35885387; rs2366963; rs651680; rs652995; rs9862311; rs35048042; rs403985; rs6769064; rs5849327; rs2461814; rs2594236; rs35130369; rs5849304; rs1447969; rs11303865; rs34045548; rs5849353; rs5849338; rs2687153; rs3836267; rs13098273; rs33954692; rs2736772; rs35803823; rs36152393; rs33999420; rs34523561; rs4093062; rs36100330; rs35688021; rs9820087; rs9851914; rs3772463; rs9856567; rs4345028; rs598667; rs10621207; rs11391493; rs13066408; rs17062079; rs12630462; rs41464544; rs34416528; rs35886908; rs5849331; rs11409205; rs13059468; rs17062608; rs7429694; rs11306382; rs10539248; rs5849306; rs5849341; rs35444265; rs35595242; rs926051; rs2471813; rs12636054; rs661793; rs35582169; rs2734357; rs596484; rs672225; rs35579400; rs2736773; rs35035916; rs11459824; rs13087298; rs7609900; rs1157725; rs9833904; rs10575171; rs35607797; rs9826037; rs34056992; rs35302219; rs13314508; rs5849299; rs35179858; rs17062867; rs378987; rs35969709; rs419378; rs2630157; rs17061862; rs11293927; rs34821370; rs419289; rs11317928; rs11447360; rs34706556; rs34305760; rs11432702; rs2362886; rs41528049; rs2630150; rs13321570; rs35003645; rs614379; rs2078287; rs35308092; rs35828639; rs34971218; rs2885638; rs192674; rs663259; rs9861639; rs673756; rs33957118; rs35230052; rs10614391; rs36226341; rs171354; rs17321950; rs525882; rs36101680; rs4426639; rs6765118; rs35745980; rs13061672; rs12107803; rs10530242; rs13088112; rs34878050; rs3894424; rs2687162; rs28709472; rs13069256; rs678205; rs35543812; rs35086778; rs550155; rs35788291; rs2886861; rs4019406; rs35452876; rs5849348; rs35510391; rs10212368; rs7642636; rs7647555; rs4368451; rs7340590; rs1683346; rs661807; rs409069; rs11438335; rs10575692; rs28562847; rs34188830; rs425711; rs2687902; rs28522697; rs12629110; rs1683640; rs615553; rs11716940; rs242211; rs10621463; rs35524867; rs28635962; rs2611413; rs1683345; rs11456273; rs11334849; rs11276736; rs5029598; rs9818923; rs35292894; rs34289599; rs11719378; rs34507740; rs633638; rs35508599; rs1825633; rs5849318; rs9828307; rs169838; rs2594243; rs34799084; rs34944059; rs1038518; rs34514881; rs17062159; rs381660; rs401985; rs9875995; rs688311; rs35261444; rs9848288; rs34408566; rs6766813; rs35064454; rs6791055; rs4679634; rs7616798; rs9881424; rs615356; rs6804443; rs11276292; rs36220407; rs34924899; rs615964; rs35520149; rs36059015; rs5849313; rs2981569; rs35903040; rs4679503; rs6785999; rs13069423; rs34997506; rs5849295; rs11401439; rs1155530; rs11917500; rs11918782; rs11921025; rs11926456; rs11928674; rs12489342; rs12632717; rs12632761; rs13314029; rs13321532; rs13324900; rs13324942; rs1385718; rs1632176; rs1683361; rs17061148; rs17061153; rs17063890; rs1716730; rs1716741; rs172407; rs17274570; rs1735454; rs1735476; rs186059; rs1868227; rs213321; rs2363681; rs2605444; rs293600; rs293601; rs2949013; rs2981568; rs34491188; rs4343583; rs4542973; rs4688167; rs503665; rs6445200; rs6764043; rs6774103; rs6785875; rs6790549; rs6797892; rs689364; rs7619791; rs7623666; rs7629722; rs780373; rs780710; rs970387; rs9824756; rs9858223; rs9860907; rs9865712; rs9873085; rs9880069; rs9990332

# Metabolic_Enzyme_71_General_References:
8598045; 9012482; 8794732; 9261067; 9323207; 9576908

# Metabolic_Enzyme_71_References:
Not Available

# Metabolic_Enzyme_72_ID:
5888

# Metabolic_Enzyme_72_Name:
High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

# Metabolic_Enzyme_72_Synonyms:
Not Available

# Metabolic_Enzyme_72_Gene_Name:
PDE9A

# Metabolic_Enzyme_72_Protein_Sequence:
>Highaffinity cGMPspecific 3',5'cyclic phosphodiesterase 9
AMGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDA
MVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRR
EGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVAN
HLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRD
VPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWL
FCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGY
NNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITL
ILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDC
LLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIM
LQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA

# Metabolic_Enzyme_72_Number_of_Residues:
593

# Metabolic_Enzyme_72_Molecular_Weight:
68493

# Metabolic_Enzyme_72_Theoretical_pI:
6.10

# Metabolic_Enzyme_72_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_72_General_Function:
Not Available

# Metabolic_Enzyme_72_Specific_Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase has a high affinity for cGMP

# Metabolic_Enzyme_72_Pathway:
Not Available

# Metabolic_Enzyme_72_Reaction:
guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate

# Metabolic_Enzyme_72_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_72_Signals:
None

# Metabolic_Enzyme_72_Transmembrane_Regions:
None

# Metabolic_Enzyme_72_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_72_EC_Link:
EC 3.1.4.35

# Metabolic_Enzyme_72_GenBank_ID_Protein:
3242777

# Metabolic_Enzyme_72_SwissProt_ID:
PDE9A_HUMAN (O76083)

# Metabolic_Enzyme_72_swissprot_Name:
Not Available

# Metabolic_Enzyme_72_Genecard_id:
PDE9A

# Metabolic_Enzyme_72_Geneatlas_id:
PDE9A

# Metabolic_Enzyme_72_hgnc_id:
HGNC:8795

# Metabolic_Enzyme_72_PDB_ID:
Not Available

# Metabolic_Enzyme_72_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_72_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_72_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_72_Gene_Sequence:
>1782 bp
ATGGGATCCGGCTCCTCCAGCTACCGGCCCAAGGCCATCTACCTGGACATCGATGGACGC
ATTCAGAAGGTAATCTTCAGCAAGTACTGCAACTCCAGCGACATCATGGACCTGTTCTGC
ATCGCCACCGGCCTGCCTCGGAACACGACCATCTCCCTGCTGACCACCGACGACGCCATG
GTCTCCATCGACCCCACCATGCCCGCGAATTCAGAACGCACTCCGTACAAAGTGAGACCT
GTGGCCATCAAGCAACTCTCCGCTGGTGTCGAGGACAAGAGAACCACAAGCCGTGGCCAG
TCTGCTGAGAGACCACTGAGGGACAGACGGGTTGTGGGCCTGGAGCAGCCCCGGAGGGAA
GGAGCATTTGAAAGTGGACAGGTAGAGCCCAGGCCCAGAGAGCCCCAGGGCTGCTACCAG
GAAGGCCAGCGCATCCCTCCAGAGAGAGAAGAATTAATCCAGAGCGTGCTGGCGCAGGTT
GCAGAGCAGTTCTCAAGAGCATTCAAAATCAATGAACTGAAAGCTGAAGTTGCAAATCAC
TTGGCTGTCCTAGAGAAACGCGTGGAATTGGAAGGACTAAAAGTGGTGGAGATTGAGAAA
TGCAAGAGTGACATTAAGAAGATGAGGGAGGAGCTGGCGGCCAGAAGCAGCAGGACCAAC
TGCCCCTGTAAGTACAGTTTTTTGGATAACCACAAGAAGTTGACTCCTCGACGCGATGTT
CCCACTTACCCCAAGTACCTGCTCTCTCCAGAGACCATCGAGGCCCTGCGGAAGCCGACC
TTTGACGTCTGGCTTTGGGAGCCCAATGAGATGCTGAGCTGCCTGGAGCACATGTACCAC
GACCTCGGGCTGGTCAGGGACTTCAGCATCAACCCTGTCACCCTCAGGAGGTGGCTGTTC
TGTGTCCACGACAACTACAGAAACAACCCCTTCCACAACTTCCGGCACTGCTTCTGCGTG
GCCCAGATGATGTACAGCATGGTCTGGCTCTGCAGTCTCCAGGAGAAGTTCTCACAAACG
GATATCCTGATCCTAATGACAGCGGCCATCTGCCACGATCTGGACCATCCCGGCTACAAC
AACACGTACCAGATCAATGCCCGCACAGAGCTGGCGGTCCGCTACAATGACATCTCACCG
CTGGAGAACCACCACTGCGCCGTGGCCTTCCAGATCCTCGCCGAGCCTGAGTGCAACATC
TTCTCCAACATCCCACCTGATGGGTTCAAGCAGATCCGACAGGGAATGATCACATTAATC
TTGGCCACTGACATGGCAAGACATGCAGAAATTATGGATTCTTTCAAAGAGAAAATGGAG
AATTTTGACTACAGCAACGAGGAGCACATGACCCTGCTGAAGATGATTTTGATAAAATGC
TGTGATATCTCTAACGAGGTCCGTCCAATGGAAGTCGCAGAGCCTTGGGTGGACTGTTTA
TTAGAGGAATATTTTATGCAGAGCGACCGTGAGAAGTCAGAAGGCCTTCCTGTGGCACCG
TTCATGGACCGAGACAAAGTGACCAAGGCCACAGCCCAGATTGGGTTCATCAAGTTTGTC
CTGATCCCAATGTTTGAAACAGTGACCAAGCTCTTCCCCATGGTTGAGGAGATCATGCTG
CAGCCACTTTGGGAATCCCGAGATCGCTACGAGGAGCTGAAGCGGATAGATGACGCCATG
AAAGAGTTACAGAAGAAGACTGACAGCTTGACGTCTGGGGCCACCGAGAAGTCCAGAGAG
AGAAGCAGAGATGTGAAAAACAGTGAAGGAGACTGTGCCTGA

# Metabolic_Enzyme_72_GenBank_ID_Gene:
AF048837

# Metabolic_Enzyme_72_Chromosome_Location:
Not Available

# Metabolic_Enzyme_72_Locus:
Not Available

# Metabolic_Enzyme_72_SNPs:
Not Available

# Metabolic_Enzyme_72_General_References:
9624146; 9856478; 12565835; 14527714; 10830953

# Metabolic_Enzyme_72_References:
Not Available

# Metabolic_Enzyme_73_ID:
5889

# Metabolic_Enzyme_73_Name:
cGMP-dependent 3',5'-cyclic phosphodiesterase

# Metabolic_Enzyme_73_Synonyms:
Cyclic GMP-stimulated phosphodiesterase; CGS-PDE; cGSPDE

# Metabolic_Enzyme_73_Gene_Name:
PDE2A

# Metabolic_Enzyme_73_Protein_Sequence:
>cGMPdependent 3',5'cyclic phosphodiesterase
MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN
GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV
EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL
DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV
EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD
EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE
ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD
AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF
SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF
ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH
AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS
SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL
QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM
GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH
KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE

# Metabolic_Enzyme_73_Number_of_Residues:
941

# Metabolic_Enzyme_73_Molecular_Weight:
105718

# Metabolic_Enzyme_73_Theoretical_pI:
5.08

# Metabolic_Enzyme_73_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_73_General_Function:
Not Available

# Metabolic_Enzyme_73_Specific_Function:
Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP)

# Metabolic_Enzyme_73_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_73_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_73_Pfam_Domain_Function:
PF01590:GAF;
PF00233:PDEase_I

# Metabolic_Enzyme_73_Signals:
None

# Metabolic_Enzyme_73_Transmembrane_Regions:
None

# Metabolic_Enzyme_73_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_73_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_73_GenBank_ID_Protein:
2108052

# Metabolic_Enzyme_73_SwissProt_ID:
PDE2A_HUMAN (O00408)

# Metabolic_Enzyme_73_swissprot_Name:
Not Available

# Metabolic_Enzyme_73_Genecard_id:
PDE2A

# Metabolic_Enzyme_73_Geneatlas_id:
PDE2A

# Metabolic_Enzyme_73_hgnc_id:
HGNC:8777

# Metabolic_Enzyme_73_PDB_ID:
Not Available

# Metabolic_Enzyme_73_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_73_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_73_Subcellular_Location:
Membrane; peripheral membrane protein (Potential)

# Metabolic_Enzyme_73_Gene_Sequence:
>2826 bp
ATGGGGCAGGCATGCGGCCACTCCATCCTCTGCAGGAGCCAGCAGTACCCGGCAGCGCGA
CCGGCTGAGCCGCGGGGCCAGCAGGTCTTCCTCAAGCCGGACGAGCCGCCGCCGCCGCCG
CAGCCATGCGCCGACAGCCTGCAGGACGCCTTGCTGAGTCTGGGCTCTGTCATCGACATT
TCAGGCCTGCAACGTGCTGTCAAGGAGGCCCTGTCAGCTGTGCTCCCCCGAGTGGAAACT
GTCTACACCTACCTACTGGATGGTGAGTCCCAGCTGGTGTGTGAGGACCCCCCACATGAG
CTGCCCCAGGAGGGGAAAGTCCGGGAGGCTATCATCTCCCAGAAGCGGCTGGGCTGCAAT
GGGCTGGGCTTCTCAGACCTGCCAGGGAAGCCCTTGGCCAGGCTGGTGGCTCCACTGGCT
CCTGATACCCAAGTGCTGGTCATGCCGCTAGCGGACAAGGAGGCTGGGGCCGTGGCAGCT
GTCATCTTGGTGCACTGTGGCCAGCTGAGTGATAATGAGGAATGGAGCCTGCAGGCGGTG
GAGAAGCATACCCTGGTCGCCCTGCGGAGGGTGCAGGTCCTGCAGCAGCGCGGGCCCAGG
GAGGCTCCCCGAGCCGTCCAGAACCCCCCGGAGGGGACGGCGGAAGACCAGAAGGGCGGG
GCGGCGTACACCGACCGCGACCGCAAGATCCTCCAACTGTGCGGGGAACTCTACGACCTG
GATGCCTCTTCCCTGCAGCTCAAAGTGCTCCAATACCTGCAGCAGGAGACCCGGGCATCC
CGCTGCTGCCTCCTGCTGGTGTCGGAGGACAATCTCCAGCTTTCTTGCAAGGTCATCGGA
GACAAAGTGCTCGGGGAAGAGGTCAGCTTTCCCTTGACAGGATGCCTGGGCCAGGTGGTG
GAAGACAAGAAGTCCATCCAGCTGAAGGACCTCACCTCCGAGGATGTACAACAGCTGCAG
AGCATGTTGGGCTGTGAGCTGCAGGCCATGCTCTGTGTCCCTGTCATCAGCCGGGCCACT
GACCAGGTGGTGGCCTTGGCCTGCGCCTTCAACAAGCTAGAAGGAGACTTGTTCACCGAC
GAGGACGAGCATGTGATCCAGCACTGCTTCCACTACACCAGCACCGTGCTCACCAGCACC
CTGGCCTTCCAGAAGGAACAGAAACTCAAGTGTGAGTGCCAGGCTCTTCTCCAAGTGGCA
AAGAACCTCTTCACCCACCTGGATGACGTCTCTGTCCTGCTCCAGGAGATCATCACGGAG
GCCAGAAACCTCAGCAACGCAGAGATCTGCTCTGTGTTCCTGCTGGATCAGAATGAGCTG
GTGGCCAAGGTGTTCGACGGGGGCGTGGTGGATGATGAGAGCTATGAGATCCGCATCCCG
GCCGATCAGGGCATCGCGGGACACGTGGCGACCACGGGCCAGATCCTGAACATCCCTGAC
GCATATGCCCATCCGCTTTTCTACCGCGGCGTGGACGACAGCACCGGCTTCCGCACGCGC
AACATCCTCTGCTTCCCCATCAAGAACGAGAACCAGGAGGTCATCGGTGTGGCCGAGCTG
GTGAACAAGATCAATGGGCCATGGTTCAGCAAGTTCGACGAGGACCTGGCGACGGCCTTC
TCCATCTACTGCGGCATCAGCATCGCCCATTCTCTCCTATACAAAAAAGTGAATGAGGCT
CAGTATCGCAGCCACCTGGCCAATGAGATGATGATGTACCACATGAAGGTCTCCGACGAT
GAGTATACCAAACTTCTCCATGATGGGATCCAGCCTGTGGCTGCCATTGACTCCAATTTT
GCAAGTTTCACCTATACCCCTCGTTCCCTGCCCGAGGATGACACGTCCATGGCCATCCTG
AGCATGCTGCAGGACATGAATTTCATCAACAACTACAAAATTGACTGCCCGACCCTGGCC
CGGTTCTGTTTGATGGTGAAGAAGGGCTACCGGGATCCCCCCTACCACAACTGGATGCAC
GCCTTTTCTGTCTCCCACTTCTGCTACCTGCTCTACAAGAACCTGGAGCTCACCAACTAC
CTCGAGGACATCGAGATCTTTGCCTTGTTTATTTCCTGCATGTGTCATGACCTGGACCAC
AGAGGCACAAACAACTCTTTCCAGGTGGCCTCGAAATCTGTGCTGGCTGCGCTCTACAGC
TCTGAGGGCTCCGTCATGGAGAGGCACCACTTTGCTCAGGCCATCGCCATCCTCAACACC
CACGGCTGCAACATCTTTGATCATTTCTCCCGGAAGGACTATCAGCGCATGCTGGATCTG
ATGCGGGACATCATCTTGGCCACAGACCTGGCCCACCATCTCCGCATCTTCAAGGACCTC
CAGAAGATGGCTGAGGTGGGCTACGACCGAAACAACAAGCAGCACCACAGACTTCTCCTC
TGCCTCCTCATGACCTCCTGTGACCTCTCTGACCAGACCAAGGGCTGGAAGACTACGAGA
AAGATCGCGGAGCTGATCTACAAAGAATTCTTCTCCCAGGGAGACCTGGAGAAGGCCATG
GGCAACAGGCCGATGGAGATGATGGACCGGGAGAAGGCCTATATCCCTGAGCTGCAAATC
AGCTTCATGGAGCACATTGCAATGCCCATCTACAAGCTGTTGCAGGACCTGTTCCCCAAA
GCGGCAGAGCTGTACGAGCGCGTGGCCTCCAACCGTGAGCACTGGACCAAGGTGTCCCAC
AAGTTCACCATCCGCGGCCTCCCAAGTAACAACTCGCTGGACTTCCTGGATGAGGAGTAC
GAGGTGCCTGATCTGGATGGCACTAGGGCCCCCATCAATGGCTGCTGCAGCCTTGATGCT
GAGTGA

# Metabolic_Enzyme_73_GenBank_ID_Gene:
U67733

# Metabolic_Enzyme_73_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_73_Locus:
11q13.4

# Metabolic_Enzyme_73_SNPs:
rs341047; rs1135029; rs4944557; rs392565; rs1980091; rs392818; rs11824084; rs458575; rs341087; rs366068; rs371862; rs467139; rs3781913; rs7111188; rs4944584; rs2047506; rs1513780; rs1009708; rs4944643; rs458275; rs11235555; rs341061; rs746399; rs907857; rs11822008; rs189332; rs2035467; rs904469; rs341086; rs11820891; rs11235551; rs907851; rs458437; rs3781931; rs184654; rs426907; rs7934444; rs405851; rs755933; rs11235543; rs7105428; rs376724; rs429075; rs370013; rs907856; rs4943939; rs401801; rs459546; rs4944591; rs462491; rs3825009; rs12363065; rs3781926; rs1038377; rs932074; rs433270; rs455611; rs401999; rs4944608; rs382163; rs7119321; rs11826028; rs10898860; rs10898857; rs755932; rs459309; rs341088; rs676911; rs456405; rs932075; rs1513781; rs676845; rs342326; rs907858; rs4944563; rs341049; rs907850; rs1467135; rs1877652; rs4944639; rs3781916; rs4944635; rs2365774; rs424234; rs1391888; rs342321; rs4943961; rs11603497; rs11828329; rs3781939; rs11235548; rs457556; rs341085; rs460633; rs2365769; rs399874; rs168173; rs90409; rs3781923; rs7930245; rs10793036; rs377432; rs754042; rs458360; rs462177; rs11821068; rs171021; rs3781932; rs341052; rs11235559; rs10898861; rs402250; rs572421; rs428355; rs7115561; rs408269; rs342322; rs1980090; rs7126790; rs341048; rs10898855; rs1980089; rs341059; rs11235557; rs11823678; rs12804316; rs4944599; rs11602224; rs10898856; rs3842265; rs11235558; rs341051; rs10793037; rs878277; rs12290945; rs1513779; rs10898858; rs342327; rs7108786; rs163692; rs7108477; rs455631; rs17162381; rs341050; rs11604837; rs236034; rs877133; rs907849; rs459886; rs163693; rs2365773; rs12797791; rs12797368; rs3781938; rs644698; rs462720; rs464853; rs341089; rs12146545; rs11604034; rs577536; rs3741159; rs11235550; rs11605051; rs4944589; rs11600831; rs11235547; rs17162383; rs1079117; rs11602616; rs11601122; rs371903; rs341039; rs466023; rs341060; rs11235546; rs7924891; rs371412; rs409816; rs907854; rs168175; rs11235552; rs17162385; rs12289096; rs2280098; rs414178; rs466929; rs12797628; rs7946369; rs7926573; rs151449; rs10751207; rs342323; rs11824863; rs11826928; rs907853; rs3781934; rs7111810; rs452228; rs11235549; rs1391887; rs341035; rs7123699; rs3781933; rs415399; rs341058; rs402479; rs3758936; rs3758935; rs443510; rs17857242; rs17854062; rs1056864; rs34999278; rs1299161; rs35034069; rs1056859; rs36006389; rs35330308; rs1695326; rs10629768; rs35374828; rs10599676; rs11235556; rs11235563; rs2648427; rs11235544; rs34217943; rs465873; rs11235560; rs180539; rs3842266; rs34273765; rs34673418; rs1467134; rs35973297; rs34219591; rs379638; rs415603; rs12276767; rs34845765; rs7111915; rs11235542; rs36088997; rs163608; rs2037030; rs7110834; rs35791363; rs12800996; rs341084; rs12291404; rs3825011; rs11235562; rs35209015; rs34659576; rs390130; rs34678444; rs5792598; rs34885656; rs631552; rs28435513; rs35457068; rs34561755; rs34903353; rs1079116; rs33965768; rs34055117; rs7941968; rs28681095; rs367195; rs341062; rs3781937; rs7930640; rs3837412; rs3781915; rs34720752; rs366711; rs236908; rs12362256; rs35491439; rs34815390; rs10751208; rs35179366; rs10577236; rs34468837; rs341038; rs7110760; rs1513782; rs3741160; rs11235545; rs11421754; rs34212074; rs34648431; rs3741158; rs7933910; rs459854; rs33948641; rs12787971; rs341037; rs7128760; rs12805517; rs34992676; rs34755048; rs35351102; rs4944570; rs5792597; rs12420120; rs34958282; rs3781924; rs12796885; rs384892; rs12223388; rs36025018; rs7482093; rs34346276; rs12789554; rs11824399; rs34173798; rs12275807; rs12293769; rs10552751; rs7935955; rs34927568; rs35642115; rs12276624; rs4944566; rs35534137; rs11603077; rs12790170; rs465512; rs34193719; rs3832776; rs35014697; rs168174; rs12280849; rs7110717; rs438969; rs2271524; rs3837413; rs342320; rs907855; rs36022812; rs35320110; rs12279246; rs10533778; rs35814877; rs35309746; rs12287467; rs7123937; rs7115954; rs379276; rs12276229; rs10666854; rs2128913; rs3062165; rs6144389; rs394903; rs10706560; rs12099061; rs341036; rs34274987; rs34893653; rs4990737; rs1681502; rs35905219; rs11605720; rs34977751; rs7951461; rs34098578; rs10636062; rs35667827; rs35562683; rs11235553; rs5792596; rs11362512; rs34720227; rs35148742; rs456119; rs12281128; rs11235561; rs35057014; rs34150026; rs35365831; rs12290975; rs12786089; rs34706617; rs35360874; rs341057; rs186882; rs11235541; rs35255183; rs11235540; rs11235565; rs11604811; rs11823971; rs12421911; rs12576046; rs12576058; rs12787293; rs12799451; rs1473885; rs163694; rs341054; rs341056; rs34285624; rs35730889; rs365274; rs366066; rs3758934; rs380126; rs387354; rs393479; rs393561; rs409512; rs433640; rs433837; rs6592481; rs670066; rs7104461; rs7117518; rs7952279

# Metabolic_Enzyme_73_General_References:
9210593

# Metabolic_Enzyme_73_References:
Not Available

# Metabolic_Enzyme_74_ID:
5890

# Metabolic_Enzyme_74_Name:
Ubiquitin-activating enzyme E1

# Metabolic_Enzyme_74_Synonyms:
A1S9 protein

# Metabolic_Enzyme_74_Gene_Name:
UBE1

# Metabolic_Enzyme_74_Protein_Sequence:
>Ubiquitinactivating enzyme E1
MSSSPLSKKRRVSGPDPKPGSNCSPAQSVLSEVPSVPTNGMAKNGSEADIDEGLYSRQLY
VLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLRE
EDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNTPLEDQLRVGEFCH
NRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARH
GFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKK
ISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCAQHGRPPRPRNEEDAAELVA
LAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPI
MQWLYFDALECLPEDKEVLTEDKCLQRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIG
CELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMN
PHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGT
LGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPA
ENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHTQYSN
NIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNPLHLDYVMAAANLFAQTYGLTG
SQDRAAVATFLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLP
GFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAA
VVGLVCLELYKVVQGHRQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEV
QGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVS
RVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR

# Metabolic_Enzyme_74_Number_of_Residues:
1058

# Metabolic_Enzyme_74_Molecular_Weight:
117850

# Metabolic_Enzyme_74_Theoretical_pI:
5.50

# Metabolic_Enzyme_74_GO_Classification:
>>>
Function:  ubiquitin-like activating enzyme activity
Function:  small protein activating enzyme activity
Function:  ubiquitin activating enzyme activity
Function:  catalytic activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_74_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_74_Specific_Function:
Activates ubiquitin by first adenylating with ATP its carboxy-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP

# Metabolic_Enzyme_74_Pathway:
Not Available

# Metabolic_Enzyme_74_Reaction:
Not Available

# Metabolic_Enzyme_74_Pfam_Domain_Function:
PF00899:ThiF;
PF02134:UBACT

# Metabolic_Enzyme_74_Signals:
None

# Metabolic_Enzyme_74_Transmembrane_Regions:
None

# Metabolic_Enzyme_74_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_74_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_74_GenBank_ID_Protein:
35830

# Metabolic_Enzyme_74_SwissProt_ID:
UBE1_HUMAN (P22314)

# Metabolic_Enzyme_74_swissprot_Name:
Not Available

# Metabolic_Enzyme_74_Genecard_id:
UBE1

# Metabolic_Enzyme_74_Geneatlas_id:
UBE1

# Metabolic_Enzyme_74_hgnc_id:
HGNC:12469

# Metabolic_Enzyme_74_PDB_ID:
Not Available

# Metabolic_Enzyme_74_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_74_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_74_Subcellular_Location:
Not Available

# Metabolic_Enzyme_74_Gene_Sequence:
>3177 bp
ATGTCCAGCTCGCCGCTGTCCAAGAAACGTCGCGTGTCCGGGCCTGATCCAAAGCCGGGT
TCTAACTGCTCCCCTGCCCAGTCCGTGTTGTCCGAAGTGCCCTCGGTGCCAACCAACGGA
ATGGCCAAGAACGGCAGTGAAGCAGACATAGACGAGGGCCTTTACTCCCGGCAGCTGTAT
GTGTTGGGCCATGAGGCAATGAAGCGGCTCCAGACATCCAGTGTCCTGGTATCAGGCCTG
CGGGGCCTGGGCGTGGAGATCGCTAAGAACATCATCCTTGGTGGGGTCAAGGCTGTTACC
CTACATGACCAGGGCACTGCCCAGTGGGCTGATCTTTCCTCCCAGTTCTACCTGCGGGAG
GAGGACATCGGTAAAAACCGGGCCGAGGTATCACAGCCCCGCCTCGCTGAGCTCAACAGC
TATGTGCCTGTCACTGCCTACACTGGACCCCTCGTTGAGGACTTCCTTAGTGGTTTCCAG
GTGGTGGTGCTCACCAACACCCCCCTGGAGGACCAGCTGCGAGTGGGTGAGTTCTGTCAC
AACCGTGGCATCAAGCTGGTGGTGGCAGGCACGCGGGGCCTGTTTGGGCAGCTCTTCTGT
GACTTTGGAGAGGAAATGATCCTCACAGATTCCAATGGGGAGCAGCCACTCAGTGCTATG
GTTTCTATGGTTACCAAGGACAACCCCGGTGTGGTTACCTGCCTGGATGAGGCCCGACAC
GGGTTTGAGAGCGGGGACTTTGTCTCCTTTTCAGAAGTACAGGGCATGGTTGAACTCAAC
GGAAATCAGCCCATGGAGATCAAAGTCCTGGGTCCTTATACCTTTAGCATCTGTGACACC
TCCAACTTCTCCGACTACATCCGTGGAGGCATCGTCAGTCAGGTCAAAGTACCTAAGAAG
ATTAGCTTTAAATCCTTGGTGGCCTCACTGGCAGAACCTGACTTTGTGGTGACGGACTTC
GCCAAGTTTTCTCGCCCTGCCCAGCTGCACATTGGCTTCCAGGCCCTGCACCAGTTCTGT
GCTCAGCATGGCCGGCCACCTCGGCCCCGCAATGAGGAGGATGCAGCAGAACTGGTAGCC
TTAGCACAGGCTGTGAATGCTCGAGCCCTGCCAGCAGTGCAGCAAAATAACCTGGACGAG
GACCTCATCCGGAAGCTGGCATATGTGGCTGCTGGGGATCTGGCACCCATAAACGCCTTC
ATTGGGGGCCTGGCTGCCCAGGAAGTCATGAAGGCCTGCTCCGGGAAGTTCATGCCCATC
ATGCAGTGGCTATACTTTGATGCCCTTGAGTGTCTCCCTCAGGACAAAGAGGTCCTCACA
GAGGACAAGTGCCTCCAGCGCCAGAACCGTTATGACGGGCAAGTGGCTGTGTTTGGCTCA
GACCTGCAAGAGAAGCTGGGCAAGCAGAAGTATTTCCTGGTGGGTGCGGGGGCCATTGGC
TGTGAGCTGCTCAAGAACTTTGCCATGATTGGGCTGGGCTGCGGGGAGGGTGGAGAAATC
ATCGTTACAGACATGGACACCATTGAGAAGTCAAATCTGAATCGACAGTTTCTTTTCCGG
CCCTGGGATGTCACGAAGTTAAAGTCTGACACGGCTGCTGCAGCTGTGCGCCAAATGAAT
CCACATATCCGGGTGACAAGCCACCAGAACCGTGTGGGTCCTGACACGGAGCGCATCTAT
GATGACGATTTTTTCCAAAACCTAGATGGCGTGGCCAATGCCCTGGACAACGTGGATGCC
CGCATGTACATGGACCGCCGCTGTGTCTACTACCGGAAGCCACTGCTGGAGTCAGGCACA
CTGGGCACCAAAGGCAATGTGCAGGTGGTGATCCCCTTCCTGACAGAGTCGTACAGTTCC
AGCCAGGACCCACCTGAGAAGTCCATCCCCATCTGTACCCTGAAGAACTTCCCTAATGCC
ATCGAGCACACCCTGCAGTGGGCTCGGGATGAGTTTGAAGGCCTCTTCAAGCAGCCAGCA
GAAAATGTCAACCAGTACCTCACAGACCCCAAGTTTGTGGAGCGAACACTGCGGCTGGCA
GGCACTCAGCCCTTGGAGGTGCTGGAGGCTGTGCAGCGCAGCCTGGTGCTGCAGCGACCA
CAGACCTGGGCTGACTGCGTGACCTGGGCCTGCCACCACTGGCACACCCAGTACTCGAAC
AACATCCGGCAGCTGCTGCACAACTTCCCTCCTGACCAGCTCACAAGCTCAGGAGCGCCG
TTCTGGTCTGGGCCCAAACGCTGTCCACACCCGCTCACCTTTGATGTCAACAATCCCCTG
CATCTGGACTATGTGATGGCTGCTGCCAACCTGTTTGCCCAGACCTACGGGCTGACAGGC
TCTCAGGACCGAGCTGCTGTGGCCACATTCCTGCAGTCTGTGCAGGTCCCCGAATTCACC
CCCAAGTCTGGCGTCAAGATCCATGTTTCTGACCAGGAGCTGCAGAGCGCCAATGCCTCT
GTTGATGACAGTCGTCTAGAGGAGCTCAAAGCCACTCTGCCCAGCCCAGACAAGCTCCCT
GGATTCAAGATGTACCCCATTGACTTTGAGAAGGATGATGACAGCAACTTTCATATGGAT
TTCATCGTGGCTGCATCCAACCTCCGGGCAGAAAACTATGACATTCCTTCTGCAGACCGG
CACAAGAGCAAGCTGATTGCAGGGAAGATCATCCCAGCCATTGCCACGACCACAGCAGCC
GTGGTTGGCCTTGTGTGTCTGGAGCTGTACAAGGTTGTGCAGGGGCACCGACAGCTTGAC
TCCTACAAGAATGGTTTCCTCAACTTGGCCCTGCCTTTCTTTGGTTTCTCTGAACCCCTT
GCCGCACCACGTCACCAGTACTATAACCAAGAGTGGACATTGTGGGATCGCTTTGAGGTA
CAAGGGCTGCAGCCTAATGGTGAGGAGATGACCCTCAAACAGTTCCTCGACTATTTTAAG
ACAGAGCACAAATTAGAGATCACCATGCTGTCCCAGGGCGTGTCCATGCTCTATTCCTTC
TTCATGCCAGCTGCCAAGCTCAAGGAACGGTTGGATCAGCCGATGACAGAGATTGTGAGC
CGTGTGTCGAAGCGAAAGCTGGGCCGCCACGTGCGGGCGCTGGTGCTTGAGCTGTGCTGT
AACGACGAGAGCGGCGAGGATGTCGAGGTTCCCTATGTCCGATACACCATCCGCTGA

# Metabolic_Enzyme_74_GenBank_ID_Gene:
X56976

# Metabolic_Enzyme_74_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_74_Locus:
Xp11.23

# Metabolic_Enzyme_74_SNPs:
rs2230147; rs2228658; rs7891904; rs4239963; rs7877968; rs4529579; rs12006836; rs5953011; rs6611347; rs7053477; rs17144858; rs7064703; rs12556965; rs12007789; rs5906354; rs11558782; rs34590238; rs1804872; rs4468050; rs35305529; rs14952; rs1127319; rs34255007; rs28633931; rs41310655; rs4347097; rs34770292; rs4239964; rs7886193; rs41312161; rs5953012; rs34440828; rs5906356; rs12688907; rs34299503; rs34304680; rs6611345; rs35869841; rs11558783; rs12391384; rs2273272; rs36107410; rs4824601; rs5906352; rs5906355; rs5952422; rs5953007; rs5953008; rs5953009; rs5953014; rs5953015; rs6611344; rs7056407; rs7887940

# Metabolic_Enzyme_74_General_References:
1606621; 1986373; 1871145; 2390975

# Metabolic_Enzyme_74_References:
Not Available

# Metabolic_Enzyme_75_ID:
5891

# Metabolic_Enzyme_75_Name:
Tyrosyl-tRNA synthetase, mitochondrial precursor

# Metabolic_Enzyme_75_Synonyms:
Tyrosine--tRNA ligase; TyrRS

# Metabolic_Enzyme_75_Gene_Name:
YARS2

# Metabolic_Enzyme_75_Protein_Sequence:
>TyrosyltRNA synthetase, mitochondrial precursor
MAAPILRSFSWGRWSGTLNLSVLLPLGLRKAHSGAQGLLAAQKARGLFKDFFPETGTKIE
LPELFDRGTASFPQTIYCGFDPTADSLHVGHLLALLGLFHLQRAGHNVIALVGGATARLG
DPSGRTKEREALETERVRANARALRLGLEALAANHQQLFTDGRSWGSFTVLDNSAWYQKQ
HLVDFLAAVGGHFRMGTLLSRQSVQLRLKSPEGMSLAEFFYQVLQAYDFYYLFQRYGCRV
QLGGSDQLGNIMSGYEFINKLTGEDVFGITVPLITSTTGAKLGKSAGNAVWLNRDKTSPF
ELYQFFVRQPDDSVERYLKLFTFLPLPEIDHIMQLHVKEPERRGPQKRLAAEVTKLVHGR
EGLDSAKRCTQALYHSSIDALEVMSDQELKELFKEAPFSEFFLDPGTSVLDTCRKANAIP
DGPRGYRMITEGGVSINHQQVTNPESVLIVGQHILKNGLSLLKIGKRNFYIIKWLQL

# Metabolic_Enzyme_75_Number_of_Residues:
477

# Metabolic_Enzyme_75_Molecular_Weight:
53200

# Metabolic_Enzyme_75_Theoretical_pI:
9.34

# Metabolic_Enzyme_75_GO_Classification:
>>>
Function:  tyrosine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  tyrosyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_75_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_75_Specific_Function:
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)

# Metabolic_Enzyme_75_Pathway:
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_75_Reaction:
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)

# Metabolic_Enzyme_75_Pfam_Domain_Function:
PF00579:tRNA-synt_1b

# Metabolic_Enzyme_75_Signals:
1-33

# Metabolic_Enzyme_75_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_75_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_75_EC_Link:
EC 6.1.1.1

# Metabolic_Enzyme_75_GenBank_ID_Protein:
4680649

# Metabolic_Enzyme_75_SwissProt_ID:
SYYM_HUMAN (Q9Y2Z4)

# Metabolic_Enzyme_75_swissprot_Name:
Not Available

# Metabolic_Enzyme_75_Genecard_id:
YARS2

# Metabolic_Enzyme_75_Geneatlas_id:
YARS2

# Metabolic_Enzyme_75_hgnc_id:
HGNC:24249

# Metabolic_Enzyme_75_PDB_ID:
Not Available

# Metabolic_Enzyme_75_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_75_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_75_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_75_Gene_Sequence:
>1431 bp
ATGGGCGCCATCTTGCGGTCCTTTTCCTGGGGCCGGTGGTCTGGTACCCTAAATCTCTCA
GTATTGTTGCCCTTGGGGCTGCGTAAGGCCCACTCGGGCGCTCAGGGGTTACTGGCAGCG
CAGAAGGCTCGAGGTCTGTTCAAGGACTTCTTCCCGGAGACGGGGACGAAAATAGAGCTC
CCAGAGCTCTTCGACCGTGGCACGGCGAGTTTTCCCCAAACCATTTACTGTGGCTTCGAC
CCCACGGCAGACTCGCTTCATGTGGGTCATCTACTTGCGCTGCTGGGTCTGTTTCATTTG
CAGCGAGCGGGCCACAACGTGATCGCGCTGGTGGGAGGCGCCACGGCGGCCCTGGGAGAC
CCGAGCGGCCGTACCAAGGAACGCGAGGCGCTGGAGACAGAGCGCGTGCGAGCCAACGCG
CGAGCTCTGCGCCTAGGGCTTGAGGCCCTGGCGGCTAATCACCAGCAGCTTTTCACTGAT
GGGCGCTCCTGGGGCAGCTTCACTGTGCTGGACAACTCGGCCTGGTACCAGAAGCAGCAC
CTGGTGGACTTCCTGGCGGCAGTGGGGGTTCACTTCCGCATGGGGACGCTGCTGAGCCGG
CAGAGCGTGCAGCTGCGGCTCAAGAGCCCCGAGGGCATGAGCTTGGCCGAGTTCTTTTAC
CAGGTGCTCCAGGCCTATGACTTCTATTACCTCTTCCAGCGTTATGGATGCAGGGTCCAG
CTGGGCGGATCTGATCAACTAGGCAACATCATGTCCGGATATGAGTTCATCAACAAGTTG
ACTGGAGAAGATGTATTTGGAATCACCGTTACTCTAATTACAAGTACAACTGGAGCAAAG
CTGGGAAAGTCTGCTGGCAACGCTGTTTGGCTAAACAGAGATAAGACATCTCCATTTGAA
TTGTATCAATTCTTTGTCAGACAACCCGAGGATTCAGTGGAAAGGTACCTGAAGCTGTTC
ACTTTCCTGCCCCTCCCAGAGATTGATCATATCATGCAGCTGCATGTCAAAGAGCCAGAA
AGGCGGGGTCCTCAGAAACGACTGGCAGCAGAAGTAACAAAGCTTGTTCATGGACGAGAA
GGATTGGATTCTGCTAAAAGGTGTACACAAGCCCTTTATCACAGTAGCATAGATGCACTG
GAGGTCATGTCTGATCAGGAGTTAAAAGAGTTGTTTAAAGAAGCTCCATTTTCTGAATTT
TTTCTCGATCCTGGAACAAGTGTCCTAGATACTTGCCGCAAAGCAAATGCCATTCCAGAT
GGTCCCCGAGGGTATCGAATGATAACAGAAGGCGGAGTCAGCATAAATCACCAACAAGTA
ACAAATCCTGAGAGTGTTTTAATTGTTGGACAACATATTCTCAAGAATGGACTTTCCTTA
CTTAAAATAGGAAAAAGAAATTTCTACATTATAAAATGGCTTCAGTTGTGA

# Metabolic_Enzyme_75_GenBank_ID_Gene:
AF132939

# Metabolic_Enzyme_75_Chromosome_Location:
Not Available

# Metabolic_Enzyme_75_Locus:
Not Available

# Metabolic_Enzyme_75_SNPs:
Not Available

# Metabolic_Enzyme_75_General_References:
10810093

# Metabolic_Enzyme_75_References:
Not Available

# Metabolic_Enzyme_76_ID:
5892

# Metabolic_Enzyme_76_Name:
Ubiquitin-conjugating enzyme E2 E1

# Metabolic_Enzyme_76_Synonyms:
Ubiquitin-protein ligase E1; Ubiquitin carrier protein E1; UbcH6

# Metabolic_Enzyme_76_Gene_Name:
UBE2E1

# Metabolic_Enzyme_76_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 E1
MSDDDSRASTSSSSSSSSNQQTEKETNTPKKKESKVSMSKNSKLLSTSAKRIQKELADIT
LDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIY
HCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEH
DRMARQWTKRYAT

# Metabolic_Enzyme_76_Number_of_Residues:
193

# Metabolic_Enzyme_76_Molecular_Weight:
21404

# Metabolic_Enzyme_76_Theoretical_pI:
8.71

# Metabolic_Enzyme_76_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_76_General_Function:
Not Available

# Metabolic_Enzyme_76_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins

# Metabolic_Enzyme_76_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_76_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_76_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_76_Signals:
None

# Metabolic_Enzyme_76_Transmembrane_Regions:
None

# Metabolic_Enzyme_76_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_76_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_76_GenBank_ID_Protein:
1064914

# Metabolic_Enzyme_76_SwissProt_ID:
UB2E1_HUMAN (P51965)

# Metabolic_Enzyme_76_swissprot_Name:
Not Available

# Metabolic_Enzyme_76_Genecard_id:
UBE2E1

# Metabolic_Enzyme_76_Geneatlas_id:
UBE2E1

# Metabolic_Enzyme_76_hgnc_id:
HGNC:12477

# Metabolic_Enzyme_76_PDB_ID:
Not Available

# Metabolic_Enzyme_76_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_76_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_76_Subcellular_Location:
Not Available

# Metabolic_Enzyme_76_Gene_Sequence:
>582 bp
ATGTCGGATGACGATTCGAGGGCCAGCACCAGCTCCTCCTCATCTTCGTCCTCCAACCAG
CAAACCGAGAAAGAAACAAACACCCCCAAGAAGAAGGAGAGTAAAGTCAGCATGAGCAAA
AACTCCAAACTCCTCTCCACCAGCGCCAAGAGAATTCAGAAGGAGCTGGCGGACATCACT
TTAGACCCTCCACCTAATTGCAGTGCTGGTCCCAAAGGCGATAACATCTATGAATGGAGA
TCAACCATTCTAGGGCCTCCAGGATCCGTGTATGAGGGTGGTGTATTCTTTCTCGATATC
ACTTTTACACCAGAATATCCCTTCAAGCCTCCAAAGGTTACATTTCGGACAAGAATCTAT
CATTGTAATATTAACAGTCAAGGTGTTATTTGCTTGGACATATTGAAAGATAATTGGAGT
CCAGCACTAACCATTTCTAAAGTCCTCCTTTCTATCTGCTCACTTCTTACAGACTGTAAT
CCTGCCGACCCCTTGGTGGGAAGTATTGCCACTCAGTATATGACCAACAGAGCAGAACAT
GACAGAATGGCCAGACAGTGGACCAAGAGATACGCTACATAA

# Metabolic_Enzyme_76_GenBank_ID_Gene:
X92963

# Metabolic_Enzyme_76_Chromosome_Location:
Not Available

# Metabolic_Enzyme_76_Locus:
Not Available

# Metabolic_Enzyme_76_SNPs:
Not Available

# Metabolic_Enzyme_76_General_References:
8576257

# Metabolic_Enzyme_76_References:
Not Available

# Metabolic_Enzyme_77_ID:
5893

# Metabolic_Enzyme_77_Name:
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

# Metabolic_Enzyme_77_Synonyms:
Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; Diadenosine tetraphosphatase; Ap4A hydrolase; Ap4Aase; Nucleoside diphosphate-linked moiety X motif 2; Nudix motif 2

# Metabolic_Enzyme_77_Gene_Name:
NUDT2

# Metabolic_Enzyme_77_Protein_Sequence:
>Bis5'nucleosyltetraphosphatase asymmetrical
MALRACGLIIFRRCLIPKVDNNAIEFLLLQASDGIHHWTPPKGHVEPGEDDLETALRETQ
EEAGIEAGQLTIIEGFKRELNYVARNKPKTVIYWLAEVKDYDVEIRLSHEHQAYRWLGLE
EACQLAQFKEMKAALQEGHQFLCSIEA

# Metabolic_Enzyme_77_Number_of_Residues:
147

# Metabolic_Enzyme_77_Molecular_Weight:
16829

# Metabolic_Enzyme_77_Theoretical_pI:
5.06

# Metabolic_Enzyme_77_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleotide diphosphatase activity
Function:  bis(5'-nucleosyl)-tetraphosphatase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_77_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_77_Specific_Function:
Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis

# Metabolic_Enzyme_77_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_77_Reaction:
P1,P4-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP

# Metabolic_Enzyme_77_Pfam_Domain_Function:
PF00293:NUDIX

# Metabolic_Enzyme_77_Signals:
None

# Metabolic_Enzyme_77_Transmembrane_Regions:
None

# Metabolic_Enzyme_77_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_77_EC_Link:
EC 3.6.1.17

# Metabolic_Enzyme_77_GenBank_ID_Protein:
1050960

# Metabolic_Enzyme_77_SwissProt_ID:
AP4A_HUMAN (P50583)

# Metabolic_Enzyme_77_swissprot_Name:
Not Available

# Metabolic_Enzyme_77_Genecard_id:
NUDT2

# Metabolic_Enzyme_77_Geneatlas_id:
NUDT2

# Metabolic_Enzyme_77_hgnc_id:
HGNC:8049

# Metabolic_Enzyme_77_PDB_ID:
1XSC

# Metabolic_Enzyme_77_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_77_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_77_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_77_Gene_Sequence:
>60 bp
ATGCCAGCCCTGTTTTACAGGGAGCCCTGGAGGAGTTGGGATAGAGGCCACATTGACTGA


# Metabolic_Enzyme_77_GenBank_ID_Gene:
U30313

# Metabolic_Enzyme_77_Chromosome_Location:
Not Available

# Metabolic_Enzyme_77_Locus:
Not Available

# Metabolic_Enzyme_77_SNPs:
Not Available

# Metabolic_Enzyme_77_General_References:
7487923

# Metabolic_Enzyme_77_References:
Not Available

# Metabolic_Enzyme_78_ID:
5894

# Metabolic_Enzyme_78_Name:
Long-chain-fatty-acid--CoA ligase 6

# Metabolic_Enzyme_78_Synonyms:
Long-chain acyl-CoA synthetase 6; LACS 6

# Metabolic_Enzyme_78_Gene_Name:
ACSL6

# Metabolic_Enzyme_78_Protein_Sequence:
>LongchainfattyacidCoA ligase 6
MQTQEILRILRLPELGDLGQFFRSLSATTLVSMGALAAILAYWFTHRPKALQPPCNLLMQ
SEEVEDSGGARRSVIGSGPQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPKQPYQW
LSYQEVADRAEFLGSGLLQHNCKACTDQFIGVFAQNRPEWIIVELACYTYSMVVVPLYDT
LGPGAIRYIINTADISTVIVDKPQKAVLLLEHVERKETPGLKLIILMDPFEEALKERGQK
CGVVIKSMQAVEDCGQENHQAPVPPQPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGF
LKVTEKVIFPRQDDVLISFLPLAHMFERVIQSVVYCHGGRVGFFQGDIRLLSDDMKALCP
TIFPVVPRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKI
QASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHV
GAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGD
IGKWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGI
VVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQVKAIHIHS
DMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM

# Metabolic_Enzyme_78_Number_of_Residues:
697

# Metabolic_Enzyme_78_Molecular_Weight:
77753

# Metabolic_Enzyme_78_Theoretical_pI:
7.46

# Metabolic_Enzyme_78_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_78_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_78_Specific_Function:
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid

# Metabolic_Enzyme_78_Pathway:
map00071  Fatty acid metabolism

# Metabolic_Enzyme_78_Reaction:
ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

# Metabolic_Enzyme_78_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_78_Signals:
1-37

# Metabolic_Enzyme_78_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_78_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_78_EC_Link:
EC 6.2.1.3

# Metabolic_Enzyme_78_GenBank_ID_Protein:
5702202

# Metabolic_Enzyme_78_SwissProt_ID:
ACSL6_HUMAN (Q9UKU0)

# Metabolic_Enzyme_78_swissprot_Name:
Not Available

# Metabolic_Enzyme_78_Genecard_id:
ACSL6

# Metabolic_Enzyme_78_Geneatlas_id:
ACSL6

# Metabolic_Enzyme_78_hgnc_id:
HGNC:16496

# Metabolic_Enzyme_78_PDB_ID:
Not Available

# Metabolic_Enzyme_78_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_78_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_78_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type III membrane protein. Peroxisome; peroxisomal membrane; single-pass type III membrane protein (By similarity). Microsome; microsomal membrane; single-pass type III membrane protein (By similarity)

# Metabolic_Enzyme_78_Gene_Sequence:
>2094 bp
ATGCAGACACAGGAGATCCTGAGGATACTGCGACTGCCTGAGCTAGGTGACTTGGAACAG
TTTTTCCGCAGCCTCTCGGCCACCACCCTCGTGAGTATGGGTGCCCTGGCTGCCATCCTT
GCCTACTGGTTCACTCAGCGGCCAAAGGCCTTGCAGCCGCCATGCAACCTCCTGATGCAG
TCAGAAGAAGTAGAGGACAGTGGCGGGGCACGGCGATCTGTGATTGGGTCTGGCCCTCAG
CTACTTACCCACTACTATGATGATGCCCGGACCATGTACCAGGTGTTCCGCCGTGGGCTT
AGCATCTCAGGGAATGGGCCCTGTCTTGGTTTCAGGAAGCCTAAGCAGCCTTACCAGTGG
CTGTCCTACCAGGAGGTGGCCGACAGGGCTGAATTTCTGGGGTCCGGACTTCTCCAGCAC
AATTGTAAAGCATGCACTGATCAGTTTATTGGTGTTTTTGCACAAAATCGGCCAGAGTGG
ATCATTGTGGAGCTGGCCTGCTACACATATTCCATGGTGGTGGTCCCGCTCTATGACACC
CTGGGCCCTGGGGCTATCCGCTACATCATCAATACAGCGGACATCAGCACCGTGATTGTG
GACAAACCTCAGAAGGCTGTGCTTCTGCTAGAGCATGTGGAGAGGAAGGAGACTCCAGGC
CTCAAGCTGATCATCCTCATGGACCCATTCGAAGAAGCCCTGAAAGAGAGAGGGCAGAAG
TGCGGGGTGGTCATTAAGTCCATGCAGGCCGTGGAGGACTGTGGCCAAGAGAATCACCAG
GCTCCTGTGCCCCCGCAGCCTGATGACCTCTCCATTGTGTGTTTCACAAGCGGCACGACA
GGGAACCCAAAAGGTGCGATGCTCACCCATGGGAACGTGGTGGCTGATTTCTCAGGCTTT
CTGAAAGTGACAGAGAGTCAGTGGGCTCCCACTTGTGCGGATGTGCACATTTCCTATTTG
CCTTTAGCACACATGTTTGAGCGAATGGTGCAGTCTGTCGTCTATTGCCACGGAGGGCGT
GTTGGCTTCTTCCAGGGAGATATCCGCCTTCTCTCAGATGACATGAAGGCTCTATGCCCC
ACCATCTTCCCTGTGGTCCCACGACTGCTGAACCGGATGTACGACAAGATCTTCAGCCAG
GCAAACACACCATTAAAGCGCTGGCTCCTGGAGTTTGCAGCAAAGCGTAAGCAAGCCGAG
GTCCGGAGTGGAATCATCAGGAATGATAGTATCTGGGATGAACTCTTCTTTAATAAGATT
CAGGCCAGTCTTGGTGGGTGTGTGCGGATGATTGTTACTGGAGCAGCCCCAGCATCACCA
ACAGTTCTGGGATTTCTCCGGGCAGCTCTAGGGTGCCAGGTTTATGAAGGTTATGGCCAA
ACTGAGTGCACAGCTGGATGTACCTTCACCACTCCTGGCGACTGGACCTCAGGGCACGTA
GGGGCGCCACTTCCCTGCAATCATATCAAGCTCGTTGATGTTGAGGAACTGAACTACTGG
GCCTGCAAAGGAGAGGGAGAGATATGTGTGAGAGGACCAAATGTGTTCAAAGGCTACTTG
AAAGATCCAGACAGGACGAAGGAGGCCCTGGACAGCGATGGCTGGCTTCACACTGGAGAC
ATCGGAAAATGGCTGCCGGCAGGAACTCTTAAAATTATTGATCGGAAAAAGCATATATTT
AAACTTGCTCAGGGAGAATATGTTGCACCCGAGAAGATTGAGAACATCTACATCCGGAGC
CAACCTGTGGCGCAAATCTATGTCCATGGGGACAGCTTAAAGGCCTTTTTGGTAGGCATT
GTTGTGCCTGACCCTGAAGTTATGCCCTCCTGGGCCCAGAAGAGAGGAATTGAAGGAACA
TATGCAGATCTCTGCACAAATAAGGATCTGAAGAAAGCCATTTTGGAAGATATGGTGAGG
TTAGGAAAAGAAAGTGGACTCCATTCTTTTGAGCAGGTTAAAGCCATTCACATCCATTCT
GACATGTTCTCAGTTCAAAATGGCTTGCTGACCCCAACACTAAAAGCTAAGAGACCTGAG
CTGAGAGAGTACTTCAAAAAACAAATAGAAGAGCTTTACTCAATCCCCATGTGA

# Metabolic_Enzyme_78_GenBank_ID_Gene:
AF129166

# Metabolic_Enzyme_78_Chromosome_Location:
Not Available

# Metabolic_Enzyme_78_Locus:
Not Available

# Metabolic_Enzyme_78_SNPs:
Not Available

# Metabolic_Enzyme_78_General_References:
10548543; 10502316; 10048485

# Metabolic_Enzyme_78_References:
Not Available

# Metabolic_Enzyme_79_ID:
5895

# Metabolic_Enzyme_79_Name:
Methionyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_79_Synonyms:
Methionine--tRNA ligase; MetRS

# Metabolic_Enzyme_79_Gene_Name:
MARS

# Metabolic_Enzyme_79_Protein_Sequence:
>MethionyltRNA synthetase, cytoplasmic
MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLF
STSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRA
LTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQE
PCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAW
EKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRL
RQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTP
QQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDK
CGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQF
ITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWW
KNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGV
GVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMF
VSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQ
VNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSI
LLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQ
QIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK


# Metabolic_Enzyme_79_Number_of_Residues:
900

# Metabolic_Enzyme_79_Molecular_Weight:
101117

# Metabolic_Enzyme_79_Theoretical_pI:
6.05

# Metabolic_Enzyme_79_GO_Classification:
>>>
Function:  methionine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  methionyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_79_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_79_Specific_Function:
ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)

# Metabolic_Enzyme_79_Pathway:
map00271  Methionine metabolism;
 map00450  Selenoamino acid metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_79_Reaction:
ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)

# Metabolic_Enzyme_79_Pfam_Domain_Function:
PF00043:GST_C;
PF09334:tRNA-synt_1g;
PF00458:WHEP-TRS

# Metabolic_Enzyme_79_Signals:
None

# Metabolic_Enzyme_79_Transmembrane_Regions:
None

# Metabolic_Enzyme_79_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_79_EC_Link:
EC 6.1.1.10

# Metabolic_Enzyme_79_GenBank_ID_Protein:
1702932

# Metabolic_Enzyme_79_SwissProt_ID:
SYMC_HUMAN (P56192)

# Metabolic_Enzyme_79_swissprot_Name:
Not Available

# Metabolic_Enzyme_79_Genecard_id:
MARS

# Metabolic_Enzyme_79_Geneatlas_id:
MARS

# Metabolic_Enzyme_79_hgnc_id:
HGNC:6898

# Metabolic_Enzyme_79_PDB_ID:
Not Available

# Metabolic_Enzyme_79_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_79_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_79_Subcellular_Location:
Cytoplasm (Probable)

# Metabolic_Enzyme_79_Gene_Sequence:
>2703 bp
ATGAGACTGTTCGTGAGTGATGGCGTCCCGGGTTGCTTGCCGGTGCTGGCCGCCGCCGGG
AGAGCCCGGGGCAGAGCAGAGGTGCTGATCAGCACTGTAGGCCCGGAAGATTGTGTGGTC
CCGTTCCTGACCCGGCCTAAGGTCCCTGTCTTGCAGGTGGATAGCGGCAACTACCTCTTC
TCCACTAGTGCAATCTGCCGATATTTTTTTTTGTTATCTGGCTGGGAGCAAGATGACCTC
ACTAACCAGTGGCTGGAATGGGAAGCGACAGAGCTGCAGCCAGCTTTGTCTGCTCCCCTG
TACTATTTAGTGGTCCAAGGCAAGAAGGGGGAAGATGTTCTTGGTTCAGTGCGGAGAGCC
CTGACTCACATTGACCACAGCTTGAGTCGTCAGAACTGTCCTTTCCTGGCTGGGGAGACA
GAATCTCTAGCCGACATTGTTTTGTGGGGAGCCCAATACCCATTACTGCAAGATCCCGCC
TACCTCCCTGAGGAGCTGAGTGCCCTGCACAGCTGGTTCCAGACACTGAGTACCCAGGAA
CCATGTCAGCGAGCTGCAGAGACTGTACTGAAACAGCAAGGTGTCCTGGCTCTCCGGCCT
TACCTCCAAAAGCAGCCCCAGCCCAGCCCCGCTGAGGGAAGGGCTGTCACCAATGAGCCT
GAGGAGGAGGAGCTGGCTACCCTATCTGAGGAGGAGATTGCTATGGCTGTTACTGCTTGG
GAGAAGGGCCTAGAAAGTTTGCCCCCGCTGCGGCCCCAGCAGAATCCAGTGTTGCCTGTG
GCTGGAGAAAGGAATGTGCTCATCACCAGTGCCCTCCCTTACGTCAACAATGTCCCCCAC
CTTGGGAACATCATTGGTTGTGTGCTCAGTGCCGATGTCTTTGCCAGGTACTCTCGCCTC
CGCCAGTGGAACACCCTCTATCTGTGTGGGACAGATGAGTATGGTACAGCAACAGAGACC
AAGGCTCTGGAGGAGGGACTAACCCCCCAGGAGATCTGCGACAAGTACCACATCATCCAT
GCTGACATCTACCGCTGGTTTAACATTTCGTTTGATATTTTTGGTCGCACCACCACTCCA
CAGCAGACCAAAATCACCCAGGACATTTTCCAGCAGTTGCTGAAACGAGGTTTTGTGCTG
CAAGATACTGTGGAGCAACTGCGATGTGAGCACTGTGCTCGCTTCCTGGCTGACCGCTTC
GTGGAGGGCGTGTGTCCCTTCTGTGGCTATGAGGAGGCTCGGGGTGACCAGTGTGACAAG
TGTGGCAAGCTCATCAATGCTGTCGAGCTTAAGAAGCCTCAGTGTAAAGTCTGCCGATCA
TGCCCTGTGGTGCAGTCGAGCCAGCACCTGTTTCTGGACCTGCCTAAGCTGGAGAAGCGA
CTGGAGGAGTGGTTGGGGAGGACATTGCCTGGCAGTGACTGGACACCCAATGCCCAGTTT
ATCACCCGTTCTTGGCTTCGGGATGGCCTCAAGCCACGCTGCATAACCCGAGACCTCAAA
TGGGGAACCCCTGTACCCTTAGAAGGTTTTGAAGACAAGGTATTCTATGTCTGGTTTGAT
GCCACTATTGGCTATCTGTCCATCACAGCCAACTACACAGACCAGTGGGAGAGATGGTGG
AAGAACCCAGAGCAAGTGGACCTGTATCAGTTCATGGCCAAAGACAATGTTCCTTTCCAT
AGCTTAGTCTTTCCTTGCTCAGCCCTAGGAGCTGAGGATAACTATACCTTGGTCAGCCAC
CTCATTGCTACAGAGTACCTGAACTATGAGGATGGGAAATTCTCTAAGAGCCGCGGTGTG
GGAGTGTTTGGGGACATGGCCCAGGACACGGGGATCCCTGCTGACATCTGGCGCTTCTAT
CTGCTGTACATTCGGCCTGAGGGCCAGGACAGTGCTTTCTCCTGGACGGACCTGCTGCTG
AAGAATAATTCTGAGCTGCTTAACAACCTGGGCAACTTCATCAACAGAGCTGGGATGTTT
GTGTCTAAGTTCTTTGGGGGCTATGTGCCTGAGATGGTGCTCACCCCTGATGATCAGCGC
CTGCTGGGCCATGTCACCCTGGAGCTCCAGCACTATCACCAGCTACTTGAGAAGGTTCGG
ATCCGGGATGCCTTGCGCAGTATCCTCACCATATCTCGACATGGCAACCAATATATTCAG
GTGAATGAGCCCTGGAAGCGGATTAAAGGCAGTGAGGCTGACAGGCAACGGGCAGGAACA
GTGACTGGCTTGGCAGTGAATATAGCTGCCTTGCTCTCTGTCATGCTTCAGCCTTACATG
CCCACGGTTAGTGCCACAATCCAGGCCCAGCTGCAGCTCCCACCTCCAGCCTGCAGTATC
CTGCTGACAAACTTCCTGTGTACCTTACCAGCAGGACACCAGATTGGCACAGTCAGTCCC
TTGTTCCAAAAATTGGAAAATGACCAGATTGAAAGTTTAAGGCAGCGCTTTGGAGGGGGC
CAGGCAAAAACGTCCCCGAAGCCAGCAGTTGTAGAGACTGTTACAACAGCCAAGCCACAG
CAGATACAAGCGCTGATGGATGAAGTGACAAAACAAGGAAACATTGTCCGAGAACTGAAA
GCACAAAAGGCAGACAAGAACGAGGTTGCTGCGGAGGTGGCGAAACTCTTGGATCTAAAG
AAACAGTTGGCTGTAGCTGAGGGGAAACCCCCTGAAGCCCCTAAAGGCAAGAAGAAAAAG
TAA

# Metabolic_Enzyme_79_GenBank_ID_Gene:
X94754

# Metabolic_Enzyme_79_Chromosome_Location:
Not Available

# Metabolic_Enzyme_79_Locus:
Not Available

# Metabolic_Enzyme_79_SNPs:
Not Available

# Metabolic_Enzyme_79_General_References:
8921912

# Metabolic_Enzyme_79_References:
Not Available

# Metabolic_Enzyme_80_ID:
5896

# Metabolic_Enzyme_80_Name:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

# Metabolic_Enzyme_80_Synonyms:
GMP-PDE alpha; PDE V-B1

# Metabolic_Enzyme_80_Gene_Name:
PDE6A

# Metabolic_Enzyme_80_Protein_Sequence:
>Rod cGMPspecific 3',5'cyclic phosphodiesterase subunit alpha
MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFSNYHSPSSMEESEI
IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV
LEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS
PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKWYHLSYLHNCETRRGQI
LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVP
PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIM
NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM
ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW
ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE
ALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD
IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH
MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACD
LSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV
CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGN
QPGGNPSPGGATTSKSCCIQ

# Metabolic_Enzyme_80_Number_of_Residues:
860

# Metabolic_Enzyme_80_Molecular_Weight:
99636

# Metabolic_Enzyme_80_Theoretical_pI:
5.48

# Metabolic_Enzyme_80_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_80_General_Function:
Not Available

# Metabolic_Enzyme_80_Specific_Function:
This protein participates in processes of transmission and amplification of the visual signal

# Metabolic_Enzyme_80_Pathway:
Not Available

# Metabolic_Enzyme_80_Reaction:
guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate

# Metabolic_Enzyme_80_Pfam_Domain_Function:
PF01590:GAF;
PF00233:PDEase_I

# Metabolic_Enzyme_80_Signals:
None

# Metabolic_Enzyme_80_Transmembrane_Regions:
None

# Metabolic_Enzyme_80_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_80_EC_Link:
EC 3.1.4.35

# Metabolic_Enzyme_80_GenBank_ID_Protein:
2366987

# Metabolic_Enzyme_80_SwissProt_ID:
PDE6A_HUMAN (P16499)

# Metabolic_Enzyme_80_swissprot_Name:
Not Available

# Metabolic_Enzyme_80_Genecard_id:
PDE6A

# Metabolic_Enzyme_80_Geneatlas_id:
PDE6A

# Metabolic_Enzyme_80_hgnc_id:
HGNC:8785

# Metabolic_Enzyme_80_PDB_ID:
Not Available

# Metabolic_Enzyme_80_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_80_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_80_Subcellular_Location:
Cell membrane; lipid-anchor; cytoplasmic side (Potential)

# Metabolic_Enzyme_80_Gene_Sequence:
>2583 bp
ATGGGCGAGGTGACAGCAGAGGAGGTGGAGAAGTTCCTGGACTCGAATATTGGCTTTGCC
AAACAGTACTACAACCTCCACTACCGGGCCAAGCTCATCTCCGACCTCCTTGGGGCCAAG
GAGGCTGCCGTGGACTTCAGCAACTACCACTCCCCGAGCAGCATGGAGGAGAGCGAAATC
ATCTTTGATCTCCTGCGGGACTTTCAGGAGAATTTACAGACAGAGAAATGCATCTTCAAT
GTCATGAAGAAGCTGTGCTTCCTCCTGCAGGCAGACCGCATGAGCCTGTTCATGTACCGG
ACCCGCAATGGCATCGCAGAGCTGGCCACCAGGCTTTTCAATGTCCACAAGGATGCTGTC
CTCGAGGACTGCCTGGTGATGCCCGACCAAGAGATCGTCTTCCCTTTGGACATGGGCATC
GTGGGCCATGTCGCACACTCTAAGAAGATTGCTAACGTCCCCAACACAGAGGAGGATGAG
CATTTCTGTGACTTTGTGGACATCCTCACAGAGTACAAGACCAAGAACATCTTGGCTTCC
CCCATAATGAATGGGAAGGATGTGGTGGCCATAATCATGGCTGTGAATAAAGTGGATGGA
TCCCACTTCACCAAGAGAGATGAAGAGATTCTTCTCAAGTACCTCAATTTTGCAAATCTA
ATCATGAAGTGGTACCACCTGAGTTACCTGCACAACTGTGAAACTCGACGTGGCCAGATA
CTGCTGTGGTCTGGGAGCAAAGTCTTTGAAGAACTTACGGACATCGAACGACAGTTCCAC
AAAGCCCTGTACACAGTCCGTGCTTTCCTCAACTGTGACAGATACTCTGTGGGTCTCTTA
GACATGACCAAGCAGAAGGAATTTTTTGATGTGTGGCCGGTTCTGATGGGTGAAGTTCCA
CCTTACTCTGGTCCCAGGACTCCGGATGGAAGAGAAATTAACTTTTACAAGGTCATTGAC
TACATCCTGCATGGCAAAGAGGACATCAAAGTCATCCCGAATCCACCTCCTGACCATTGG
GCTTTAGTAAGCGGTCTCCCCGCTTATGTTGCCCAGAATGGCCTGATTTGCAACATCATG
AACGCGCCTGCGGAGGACTTTTTTGCATTTCAGAAAGAACCTCTGGATGAGTCTGGATGG
ATGATTAAAAATGTGCTTTCAATGCCGATTGTGAACAAGAAGGAAGAAATTGTTGGAGTG
GCCACATTTTACAATCGTAAAGATGGGAAGCCCTTTGATGAAATGGATGAGACGCTCATG
GAGTCTTTGACTCAATTTCTGGGCTGGTCTGTCTTAAATCCTGACACCTATGAGTCAATG
AATAAACTTGAAAATAGGAAGGATATTTTCCAGGACATAGTAAAATATCATGTGAAGTGT
GACAATGAAGAAATTCAGAAAATCTTGAAAACCAGAGAGGTGTATGGGAAGGAGCCATGG
GAGTGTGAGGAAGAGGAGCTGGCTGAGATCCTGCAAGCGGAGCTGCCAGATGCAGATAAA
TACGAAATTAATAAATTTCACTTCAGTGACTTACCCCTAACAGAACTGGAGCTGGTAAAA
TGTGGAATACAGATGTATTATGAGCTCAAAGTGGTGGATAAATTTCACATTCCACAAGAG
GCCCTGGTGCGGTTCATGTACTCCCTGAGTAAGGGCTACCGCAAGATCACCTACCACAAC
TGGCGGCACGGCTTCAACGTGGGGCAGACCATGTTCTCCCTGCTGGTGACGGGAAAGCTG
AAGCGCTACTTCACGGACCTAGAGGCCTTGGCCATGGTCACTGCTGCTTTCTGCCATGAC
ATTGACCACAGAGGCACCAATAACCTCTACCAGATGAAATCCCAGAACCCACTGGCCAAG
CTCCATGGGTCCTCTATCTTGGAAAGACACCACTTGGAGTTTGGCAAAACACTGCTCAGA
GACGAGAGCCTGAATATCTTTCAAAACCTCAATCGTCGACAGCATGAGCATGCCATCCAC
ATGATGGACATTGCAATCATTGCCACAGACCTCGCCCTGTATTTCAAGAAGAGGACGATG
TTCCAAAAGATCGTGGATCAGTCTAAGACATATGAGAGTGAACAGGAGTGGACACAGTAC
ATGATGCTGGAGCAGACACGGAAGGAAATCGTTATGGCCATGATGATGACCGCCTGTGAT
CTCTCAGCCATCACCAAACCCTGGGAGGTGCAGAGCCAGGTAGCTCTGCTGGTGGCTGCT
GAATTCTGGGAACAAGGTGACCTGGAGCGCACGGTGCTGCAACAGAATCCCATTCCCATG
ATGGACAGAAACAAAGCAGATGAACTCCCTAAGCTTCAAGTCGGCTTCATTGACTTTGTT
TGCACCTTCGTCTACAAGGAATTCTCCCGTTTCCACGAGGAGATCACCCCAATGTTGGAC
GGGATCACCAACAATCGCAAGGAGTGGAAGGCGCTTGCTGATGAGTACGATGCCAAGATG
AAGGTGCAGGAGGAGAAGAAGCAGAAACAGCAGTCGGCCAAGTCAGCAGCCGCAGGAAAT
CAGCCGGGGGGAAACCCCAGCCCAGGGGGTGCAACTACATCCAAGTCCTGCTGCATCCAG
TAA

# Metabolic_Enzyme_80_GenBank_ID_Gene:
M26061

# Metabolic_Enzyme_80_Chromosome_Location:
Not Available

# Metabolic_Enzyme_80_Locus:
Not Available

# Metabolic_Enzyme_80_SNPs:
Not Available

# Metabolic_Enzyme_80_General_References:
2155175; 7493036

# Metabolic_Enzyme_80_References:
Not Available

# Metabolic_Enzyme_81_ID:
5897

# Metabolic_Enzyme_81_Name:
Alanyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_81_Synonyms:
Alanine--tRNA ligase; AlaRS; Renal carcinoma antigen NY-REN-42

# Metabolic_Enzyme_81_Gene_Name:
AARS

# Metabolic_Enzyme_81_Protein_Sequence:
>AlanyltRNA synthetase, cytoplasmic
MDSTLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPS
HPMAKLSRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALE
LLTQEFGIPIERLYVTYFGGDEAAGLEADLECKQIWQNLGLDDTKILPGNMKDNFWEMGD
TGPCGPCSEIHYDRIGGRDAAHLVNQDDPNVLEIWNLVFIQYNREADGILKPLPKKSIDT
GMGLERLVSVLQNKMSNYDTDLFVPYFEAIQKGTGARPYTGKVGAEDADGIDMAYRVLAD
HARTITVALADGGRPDNTGRGYVLRRILRRAVRYAHEKLNASRGFFATLVDVVVQSLGDA
FPELKKDPDMVKDIINEEEVQFLKTLSRGRRILDRKIQSLGDSKTIPGDTAWLLYDTYGF
PVDLTGLIAEEKGLVVDMDGFEEERKLAQLKSQGKGAGGEDLIMLDIYAIEELRARGLEV
TDDSPKYNYHLDSSGSYVFENTVATVMALRREKMFVEEVSTGQECGVVLDKTCFYAEQGG
QIYDEGYLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYGDLKVGDQVWLFIDEPRRRP
IMSNHTATHILNFALRSVLGEADQKGSLVAPDRLRFDFTAKGAMSTQQIKKAEEIANEMI
EAAKAVYTQDCPLAAAKAIQGLRAVFDETYPDPVRVVSIGVPVSELLDDPSGPAGSLTSV
EFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKAESLKKCLSVMEAK
VKAQTAPNKDVQREIADLGEALATAVIPQWQKDELRETLKSLKKVMDDLDRASKADVQKR
VLEKTKQFIDSNPNQPLVILEMESGASAKALNEALKLFKMHSPQTSAMLFTVDNEAGKIT
CLCQVPQNAANRGLKASEWVQQVSGLMDGKGGGKDVSAQATGKNVGCLQEALQLATSFAQ
LRLGDVKN

# Metabolic_Enzyme_81_Number_of_Residues:
968

# Metabolic_Enzyme_81_Molecular_Weight:
106812

# Metabolic_Enzyme_81_Theoretical_pI:
5.18

# Metabolic_Enzyme_81_GO_Classification:
>>>
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  alanine-tRNA ligase activity
Function:  binding
Function:  nucleic acid binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  alanyl-tRNA aminoacylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_81_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_81_Specific_Function:
ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)

# Metabolic_Enzyme_81_Pathway:
map00252  Alanine and aspartate metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_81_Reaction:
ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)

# Metabolic_Enzyme_81_Pfam_Domain_Function:
PF02272:DHHA1;
PF01411:tRNA-synt_2c;
PF07973:tRNA_SAD

# Metabolic_Enzyme_81_Signals:
None

# Metabolic_Enzyme_81_Transmembrane_Regions:
None

# Metabolic_Enzyme_81_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_81_EC_Link:
EC 6.1.1.7

# Metabolic_Enzyme_81_GenBank_ID_Protein:
1015321

# Metabolic_Enzyme_81_SwissProt_ID:
SYAC_HUMAN (P49588)

# Metabolic_Enzyme_81_swissprot_Name:
Not Available

# Metabolic_Enzyme_81_Genecard_id:
AARS

# Metabolic_Enzyme_81_Geneatlas_id:
AARS

# Metabolic_Enzyme_81_hgnc_id:
HGNC:20

# Metabolic_Enzyme_81_PDB_ID:
Not Available

# Metabolic_Enzyme_81_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_81_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_81_Subcellular_Location:
Cytoplasm (Potential)

# Metabolic_Enzyme_81_Gene_Sequence:
>2907 bp
ATGGACTCTACTCTAACAGCAAGTGAAATCCGGCAGCGATTTATAGATTTCTTCAAGAGG
AACGAGCATACGTATGTTCACTCGTCTGCCACCATCCCATTGGATGACCCCACTTTGCTC
TTTGCCAATGCAGGCATGAACCAGTTTAAACCCATTTTCCTGAACACAATTGACCCATCT
CACCCCATGGCAAAGCTGAGCAGAGCTGCCAATACCCAGAAGTGCATCCGGGCTGGGGGC
AAACAAAATGACCTGGACGATGTGGGCAAGGATGTCTATCATCACACCTTCTTCGAGATG
CTGGGCTCTTGGTCTTTTGGAGATTACTTTAAGGAATTGGCATGTAAGATGGCTCTGGAA
CTCCTCACCCAAGAGTTTGGCATTCCCATTGAAAGACTTTATGTTACTTACTTTGGCGGG
GATGAAGCAGCTGGCTTAGAAGCAGATCTGGAATGCAAACAGATCTGGCAAAATTTGGGG
CTGGATGACACCAAAATCCTCCCAGGCAACATGAAGGATAACTTCTGGGAGATGGGTGAC
ACGGGCCCCTGTGGTCCTTGCAGTGAGATCCACTACGACCGGATTGGTGGTCGGGACGCC
GCACATCTTGTCAACCAGGACGACCCTAATGTGCTGGAGATCTGGAACCTTGTGTTCATC
CAGTATAACAGGGAAGCTGATGGCATTCTGAAACCTCTTCCCAAGAAAAGCATTGACACA
GGGATGGGCCTGGAACGACTGGTATCTGTGCTGCAGAATAAGATGTCCAACTATGACACT
GACCTTTTTGTCCCTTACTTTGAAGCCATTCAGAAGGGCACAGGTGCCCGACCATACACT
GGGAAAGTTGGTGCTGAGGATGCCGATGGGATTGACATGGCCTACCGGGTGCTGGCTGAC
CATGCTCGGACCATCACTGTGGCACTGGCTGATGGTGGCCGGCCTGACAACACAGGGCGT
GGATATGTGTTGAGACGGATTCTCCGCCGAGCTGTCCGATACGCCCATGAAAAGCTCAAT
GCCAGCAGGGGCTTCTTTGCTACGTTAGTGGATGTTGTCGTCCAGTCCCTGGGAGATGCA
TTTCCTGAGCTGAAGAAGGACCCAGACATGGTGAAGGACATCATTAATGAAGAAGAGGTG
CAGTTTCTCAAGACTCTCAGCAGAGGGCGTCGCATCCTGGACAGGAAAATTCAGAGCCTG
GGAGACAGCAAGACCATTCCCGGAGACACTGCTTGGCTCCTCTATGACACCTATGGGTTT
CCAGTGGATCTGACTGGACTGATTGCTGAAGAGAAGGGCCTGGTGGTAGACATGGATGGC
TTTGAAGAGGAGAGGAAACTGGCCCAGCTGAAATCACAGGGCAAGGGAGCTGGTGGGGAA
GACCTCATTATGCTGGACATTTACGCTATCGAAGAGCTCCGGGCACGGGGTCTGGAGGTC
ACAGATGATTCCCCAAAGTACAATTACCATTTGGACTCCAGTGGTAGCTATGTATTTGAG
AACACAGTGGCTACGGTGATGGCTCTGCGCAGGGAGAAGATGTTCGTGGAAGAGGTGTCC
ACAGGCCAGGAGTGTGGAGTGGTGCTGGACAAGACCTGTTTCTATGCTGAGCAAGGAGGC
CAGATCTATGACGAAGGCTACCTGGTGAAGGTGGATGACAGCAGTGAAGATAAAACAGAG
TTTACAGTGAAGAATGCTCAGGTCCGAGGAGGGTATGTGCTACACATTGGAACCATCTAC
GGTGACCTGAAAGTGGGGGATCAGGTCTGGCTGTTTATTGATGAGCCCCGACGAAGACCC
ATCATGAGCAACCACACAGCTACGCACATTCTGAACTTCGCCCTGCGCTCAGTGCTTGGG
GAAGCTGACCAGAAAGGCTCATTGGTTGCTCCTGACCGCCTCAGATTTGACTTTACTGCC
AAGGGAGCCATGTCCACCCAACAGATCAAGAAGGCTGAAGAGATTGCTAATGAGATGATT
GAGGCAGCCAAGGCCGTCTATACCCAGGATTGCCCCCTGGCAGCAGCGAAAGCCATCCAG
GGCCTACGGGCTGTGTTTGATGAGACCTATCCTGACCCTGTGCGAGTCGTCTCCATTGGG
GTCCCGGTGTCCGAGTTGCTGGATGACCCCTCTGGGCCTGCTGGCTCCCTGACTTCTGTT
GAGTTCTGTGGGGGAACGCACCTGCGGAACTCGAGTCATGCAGGAGCTTTTGTGATCGTG
ACGGAAGAAGCCATTGCCAAGGGTATCCGGAGGATTGTGGCTGTCACAGGTGCCGAGGCC
CAGAAGGCCCTCAGGAAAGCAGAGAGCTTGAAGAAATGTCTCTCTGTCATGGAAGCCAAA
GTGAAGGCTCAGACTGCTCCAAACAAGGATGTGCAGAGGGAGATCGCTGACCTTGGAGAG
GCCCTGGCCACTGCAGTCATCCCCCAGTGGCAGAAGGATGAATTGCGGGAGACTCTCAAA
TCCCTAAAGAAGGTCATGGATGACTTGGACCGAGCCAGCAAAGCCGATGTCCAGAAACGA
GTGTTAGAGAAGACGAAGCAGTTCATCGACAGCAACCCCAACCAGCCTCTTGTCATCCTG
GAGATGGAGAGCGGCGCCTCAGCCAAGGCCCTGAATGAAGCCTTGAAGCTCTTCAAGATG
CACTCCCCTCAGACTTCTGCCATGCTCTTCACGGTGGACAATGAGGCTGGCAAGATCACG
TGCCTGTGTCAAGTCCCCCAGAATGCAGCCAATCGGGGCTTAAAAGCCAGCGAGTGGGTG
CAGCAGGTGTCAGGCTTGATGGACGGTAAAGGTGGTGGCAAGGATGTGTCTGCACAGGCC
ACAGGCAAGAACGTTGGCTGCCTGCAGGAGGCGCTGCAGCTGGCCACTTCCTTCGCCCAG
CTGCGCCTCGGGGATGTAAAGAACTGA

# Metabolic_Enzyme_81_GenBank_ID_Gene:
D32050

# Metabolic_Enzyme_81_Chromosome_Location:
Not Available

# Metabolic_Enzyme_81_Locus:
Not Available

# Metabolic_Enzyme_81_SNPs:
Not Available

# Metabolic_Enzyme_81_General_References:
7654687; 10508479

# Metabolic_Enzyme_81_References:
Not Available

# Metabolic_Enzyme_82_ID:
5898

# Metabolic_Enzyme_82_Name:
Tryptophanyl-tRNA synthetase, mitochondrial precursor

# Metabolic_Enzyme_82_Synonyms:
Tryptophan--tRNA ligase; TrpRS; (MtTrpRS

# Metabolic_Enzyme_82_Gene_Name:
WARS2

# Metabolic_Enzyme_82_Protein_Sequence:
>TryptophanyltRNA synthetase, mitochondrial precursor
MALHSMRKARERWSFIRALHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWV
RLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEH
TQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGE
DQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRI
TDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTA
RYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL


# Metabolic_Enzyme_82_Number_of_Residues:
360

# Metabolic_Enzyme_82_Molecular_Weight:
40147

# Metabolic_Enzyme_82_Theoretical_pI:
9.82

# Metabolic_Enzyme_82_GO_Classification:
>>>
Function:  tryptophan-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  tryptophanyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_82_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_82_Specific_Function:
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)

# Metabolic_Enzyme_82_Pathway:
map00380  Tryptophan metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_82_Reaction:
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)

# Metabolic_Enzyme_82_Pfam_Domain_Function:
PF00579:tRNA-synt_1b

# Metabolic_Enzyme_82_Signals:
None

# Metabolic_Enzyme_82_Transmembrane_Regions:
None

# Metabolic_Enzyme_82_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_82_EC_Link:
EC 6.1.1.2

# Metabolic_Enzyme_82_GenBank_ID_Protein:
6572289

# Metabolic_Enzyme_82_SwissProt_ID:
SYWM_HUMAN (Q9UGM6)

# Metabolic_Enzyme_82_swissprot_Name:
Not Available

# Metabolic_Enzyme_82_Genecard_id:
WARS2

# Metabolic_Enzyme_82_Geneatlas_id:
WARS2

# Metabolic_Enzyme_82_hgnc_id:
HGNC:12730

# Metabolic_Enzyme_82_PDB_ID:
Not Available

# Metabolic_Enzyme_82_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_82_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_82_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_82_Gene_Sequence:
>1083 bp
ATGGCGCTGCACTCAATGCGGAAAGCGCGTGAGCGCTGGAGCTTCATCCGGGCACTTCAT
AAGGGATCCGCAGCTGCTCCCGCTCTCCAGAAAGACAGCAAGAAGCGAGTATTTTCCGGC
ATTCAACCTACAGGAATCCTCCACCTGGGCAATTACCTGGGAGCCATTGAGAGCTGGGTG
AGGTTACAGGATGAATATGACTCTGTATTATACAGCATTGTTGACCTCCACTCCATTACT
GTCCCCCAAGACCCAGCTGTCCTTCGGCAGAGCATCCTGGACATGACTGCTGTTCTTCTT
GCCTGTGGCATAAACCCGGAAAAAAGCATCCTTTTCCAACAATCTCAGGTGTCTGAACAC
ACACAATTAAGTTGGATCCTTTCCTGCATGGTCAGACTACCTCGATTACAACATTTACAT
CAGTGGAAGGCAAAGACTACCAAGCAGAAGCACGATGGCACGGTGGGCCTGCTCACATAC
CCAGTACTCCAGGCAGCCGACATTCTGTTGTACAAGTCCACACACGTTCCTGTTGGGGAG
GATCAAGTCCAGCACATGGAACTAGTTCAGGATCTAGCACAAGGTTTCAACAAGAAGTAT
GGGGAGTTCTTTCCAGTGCCCGAGTCCATTCTCACATCCATGAAGAAGGTAAAATCCCTA
CGTGATCCTTCTGCCAAAATGTCGAAATCAGACCCTGACAAACTGGCCACCGTCCGAATA
ACAGACAGCCCAGAGGAGATAGTGCAGAAATTCCGCAAGGCTGTGACAGACTTCACCTCG
GAGGTCACCTATGACCCGGCTGGCCGCGCTGGCGTGTCCAACATAGTGGCGGTGCATGCC
GCGGTGACGGGGCTCTCCGTGGAGGAAGTGGTGCGCCGCAGCGCGGGCATGAACACTGCT
CGCTACAAGCTGGCCGTGGCAGATGCTGTGATTGAGAAGTTTGCCCCAATTAAGCGTGAA
ATTGAAAAACTGAAGCTGGACAAGGACCATTTAGAGAAGGTTTTACAAATTGGATCAGCA
AAAGCCAAAGAATTAGCATACACTGTGTGCCAGGAGGTGAAGAAATTGGTGGGTTTTCTA
TAG

# Metabolic_Enzyme_82_GenBank_ID_Gene:
AJ242739

# Metabolic_Enzyme_82_Chromosome_Location:
Not Available

# Metabolic_Enzyme_82_Locus:
Not Available

# Metabolic_Enzyme_82_SNPs:
Not Available

# Metabolic_Enzyme_82_General_References:
10828066

# Metabolic_Enzyme_82_References:
Not Available

# Metabolic_Enzyme_83_ID:
5899

# Metabolic_Enzyme_83_Name:
ADP-sugar pyrophosphatase

# Metabolic_Enzyme_83_Synonyms:
Nucleoside diphosphate-linked moiety X motif 5; Nudix motif 5; YSA1H

# Metabolic_Enzyme_83_Gene_Name:
NUDT5

# Metabolic_Enzyme_83_Protein_Sequence:
>ADPsugar pyrophosphatase
MESQEPTESSQNGKQYIISEELISEGKWVKLEKTTYMDPTGKTRTWESVKRTTRKEQTAD
GVAVIPVLQRTLHYECIVLVKQFRPPMGGYCIEFPAGLIDDGETPEAAALRELEEETGYK
GDIAECSPAVCMDPGLSNCTIHIVTVTINGDDAENARPKPKPGDGEFVEVISLPKNDLLQ
RLDALVAEEHLTVDARVYSYALALKHANAKPFEVPFLKF

# Metabolic_Enzyme_83_Number_of_Residues:
219

# Metabolic_Enzyme_83_Molecular_Weight:
24328

# Metabolic_Enzyme_83_Theoretical_pI:
4.59

# Metabolic_Enzyme_83_GO_Classification:
Not Available

# Metabolic_Enzyme_83_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_83_Specific_Function:
Hydrolyzes with similar activities ADP-ribose, ADP- mannose, and ADP-glucose. Can also hydrolyze other nucleotide sugars with low activity

# Metabolic_Enzyme_83_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_83_Reaction:
ADP-ribose + H2O = AMP + D-ribose 5-phosphate

# Metabolic_Enzyme_83_Pfam_Domain_Function:
PF00293:NUDIX

# Metabolic_Enzyme_83_Signals:
None

# Metabolic_Enzyme_83_Transmembrane_Regions:
None

# Metabolic_Enzyme_83_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_83_EC_Link:
EC 3.6.1.13

# Metabolic_Enzyme_83_GenBank_ID_Protein:
6288769

# Metabolic_Enzyme_83_SwissProt_ID:
NUDT5_HUMAN (Q9UKK9)

# Metabolic_Enzyme_83_swissprot_Name:
Not Available

# Metabolic_Enzyme_83_Genecard_id:
NUDT5

# Metabolic_Enzyme_83_Geneatlas_id:
NUDT5

# Metabolic_Enzyme_83_hgnc_id:
HGNC:8052

# Metabolic_Enzyme_83_PDB_ID:
Not Available

# Metabolic_Enzyme_83_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_83_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_83_Subcellular_Location:
Not Available

# Metabolic_Enzyme_83_Gene_Sequence:
>660 bp
ATGGAGAGCCAAGAACCAACGGAATCTTCTCAGAATGGCAAACAGTATATCATTTCAGAG
GAGTTAATTTCAGAAGGAAAATGGGTCAAGCTTGAAAAAACAACGTACATGGATCCTACT
GGTAAAACTAGAACTTGGGAATCAGTGAAACGTACAACCAGGAAAGAGCAGACTGCGGAT
GGTGTCGCGGTCATCCCCGTGCTGCAGAGAACACTTCACTATGAGTGTATCGTTCTGGTG
AAACAGTTCCGACCACCAATGGGGGGCTACTGCATAGAGTTCCCTGCAGGTCTCATAGAT
GATGGTGAAACCCCAGAAGCAGCTGCTCTCCGGGAGCTTGAAGAAGAAACTGGCTACAAA
GGGGACATTGCCGAATGTTCTCCAGCGGTCTGTATGGACCCAGGCTTGTCAAACTGTACT
ATACACATCGTGACAGTCACCATTAACGGAGATGATGCCGAAAACGCAAGGCCGAAGCCA
AAGCCAGGGGATGGAGAGTTTGTGGAAGTCATTTCTTTACCCAAGAATGACCTGCTGCAG
AGACTTGATGCTCTGGTAGCTGAAGAACATCTCACAGTGGACGCCAGGGTCTATTCCTAC
GCTCTAGCGCTGAAACATGCAAATGCAAAGCCATTTGAAGTGCCCTTCTTGAAATTTTAA


# Metabolic_Enzyme_83_GenBank_ID_Gene:
AF155832

# Metabolic_Enzyme_83_Chromosome_Location:
Not Available

# Metabolic_Enzyme_83_Locus:
Not Available

# Metabolic_Enzyme_83_SNPs:
Not Available

# Metabolic_Enzyme_83_General_References:
10567213; 10722730; 11042152

# Metabolic_Enzyme_83_References:
Not Available

# Metabolic_Enzyme_84_ID:
5900

# Metabolic_Enzyme_84_Name:
Ribose-phosphate pyrophosphokinase I

# Metabolic_Enzyme_84_Synonyms:
Phosphoribosyl pyrophosphate synthetase I; PRS-I; PPRibP

# Metabolic_Enzyme_84_Gene_Name:
PRPS1

# Metabolic_Enzyme_84_Protein_Sequence:
>Ribosephosphate pyrophosphokinase 
IMPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSG
CGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVA
GADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVT
SIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSA
GATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEA
IRRTHNGESVSYLFSHVPL

# Metabolic_Enzyme_84_Number_of_Residues:
318

# Metabolic_Enzyme_84_Molecular_Weight:
34835

# Metabolic_Enzyme_84_Theoretical_pI:
6.98

# Metabolic_Enzyme_84_GO_Classification:
>>>
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  lipoate-protein ligase activity
Function:  lipoate-protein ligase B activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  diphosphotransferase activity
Function:  ribose phosphate diphosphokinase activity
 ||
>>>
Process:  nucleotide biosynthesis
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleoside monophosphate metabolism
Process:  nucleoside monophosphate biosynthesis
Process:  ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_84_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_84_Specific_Function:
ATP + D-ribose 5-phosphate = AMP + 5-phospho- alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_84_Pathway:
map00030  Pentose phosphate pathway;
 map00230  Purine metabolism

# Metabolic_Enzyme_84_Reaction:
ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_84_Pfam_Domain_Function:
PF00156:Pribosyltran

# Metabolic_Enzyme_84_Signals:
None

# Metabolic_Enzyme_84_Transmembrane_Regions:
None

# Metabolic_Enzyme_84_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_84_EC_Link:
EC 2.7.6.1

# Metabolic_Enzyme_84_GenBank_ID_Protein:
35702

# Metabolic_Enzyme_84_SwissProt_ID:
PRPS1_HUMAN (P60891)

# Metabolic_Enzyme_84_swissprot_Name:
Not Available

# Metabolic_Enzyme_84_Genecard_id:
PRPS1

# Metabolic_Enzyme_84_Geneatlas_id:
PRPS1

# Metabolic_Enzyme_84_hgnc_id:
HGNC:9462

# Metabolic_Enzyme_84_PDB_ID:
Not Available

# Metabolic_Enzyme_84_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_84_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_84_Subcellular_Location:
Not Available

# Metabolic_Enzyme_84_Gene_Sequence:
>957 bp
ATGCCGAATATCAAAATCTTCAGCGGCAGTTCCCACCAGGACTTATCTCAGAAAATTGCT
GACCGCCTGGGCCTGGAGCTAGGCAAGGTGGTGACTAAGAAGTTCAGCAACCAGGAGACC
TGTGTGGAAATCGGTGAAAGTGTACGTGGAGAGGATGTCTACATTGTTCAGAGTGGTTGT
GGCGAAATCAATGACAATTTAATGGAGCTTTTGATCATGATTAATGCCTGCAAGATTGCT
TCAGCCAGCCGGGTTACTGCAGTCATCCCATGCTTCCCTTATGCCCGGCAGGATAAGAAG
GATAAGAGCCGGGCGCCAATCTCAGCCAAGCTTGTTGCAAATATGCTATCTGTAGCAGGT
GCAGATCATATTATCACCATGGACCTACATGCTTCTCAAATTCAGGGCTTTTTTGATATC
CCAGTAGACAATTTGTATGCAGAGCCGGCTGTCCTAAAGTGGATAAGGGAGAATATCTCT
GAGTGGAGGAACTGCACTATTGTCTCACCTGATGCTGGTGGAGCTAAGAGAGTGACCTCC
ATTGCAGACAGGCTGAATGTGGACTTTGCCTTGATTCACAAAGAACGGAAGAAGGCCAAT
GAAGTGGACCGCATGGTGCTTGTGGGAGATGTGAAGGATCGGGTGGCCATCCTTGTGGAT
GACATGGCTGACACTTGTGGCACAATCTGCCATGCAGCTGACAAACTTCTCTCAGCTGGC
GCCACCAGAGTTTATGCCATCTTGACTCATGGAATCTTCTCCGGTCCTGCTATTTCTCGC
ATCAACAACGCATGCTTTGAGGCAGTAGTAGTCACCAATACCATACCTCAGGAGGACAAG
ATGAAGCATTGCTCCAAAATACAGGTGATTGACATCTCTATGATCCTTGCAGAAGCCATC
AGGAGAACTCACAATGGAGAATCCGTTTCTTACCTATTCAGCCATGTCCCTTTATAA

# Metabolic_Enzyme_84_GenBank_ID_Gene:
X15331

# Metabolic_Enzyme_84_Chromosome_Location:
Not Available

# Metabolic_Enzyme_84_Locus:
Not Available

# Metabolic_Enzyme_84_SNPs:
Not Available

# Metabolic_Enzyme_84_General_References:
2155397; 1650777; 1314091; 7593598

# Metabolic_Enzyme_84_References:
Not Available

# Metabolic_Enzyme_85_ID:
5901

# Metabolic_Enzyme_85_Name:
Seryl-tRNA synthetase, mitochondrial precursor

# Metabolic_Enzyme_85_Synonyms:
Seryl- tRNA(Ser/Secsynthetase; Serine--tRNA ligase; SerRSmt

# Metabolic_Enzyme_85_Gene_Name:
SARS2

# Metabolic_Enzyme_85_Protein_Sequence:
>SeryltRNA synthetase, mitochondrial precursor
MAASMARRLWPLLTRRGFRPRGGCISNDSPRRSFTTEKRNRNLLYEYAREGYSALPQLDI
ERFCACPEEAAHALELRKGELRSADLPAIISTWQELRQLQEQIRSLEEEKAAVTEAVRAL
LANQDSGEVQQDPKYQGLRARGREIRKELVHLYPREAQLEEQFYLQALKLPNQTHPDVPV
GDESQARVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQH
GLVNFTFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNIDPARFKDLNLAGTA
EVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNTGQEPRGLYRVHHFTKVEMFGVTGPG
LEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRFGEVT
SASNCTDFQSRRLHIMFQTEAGELQFAHTVNATACAVPRLLIALLESNQQKDGSVLVPPA
LQSYLGTDRITAPTHVPLQYIGPNQPRKPGLPGQPAVS

# Metabolic_Enzyme_85_Number_of_Residues:
518

# Metabolic_Enzyme_85_Molecular_Weight:
58283

# Metabolic_Enzyme_85_Theoretical_pI:
8.22

# Metabolic_Enzyme_85_GO_Classification:
>>>
Function:  serine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  seryl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_85_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_85_Specific_Function:
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

# Metabolic_Enzyme_85_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_85_Reaction:
ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)

# Metabolic_Enzyme_85_Pfam_Domain_Function:
PF02403:Seryl_tRNA_N;
PF00587:tRNA-synt_2b

# Metabolic_Enzyme_85_Signals:
1-24

# Metabolic_Enzyme_85_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_85_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_85_EC_Link:
EC 6.1.1.11

# Metabolic_Enzyme_85_GenBank_ID_Protein:
9188535

# Metabolic_Enzyme_85_SwissProt_ID:
SYSM_HUMAN (Q9NP81)

# Metabolic_Enzyme_85_swissprot_Name:
Not Available

# Metabolic_Enzyme_85_Genecard_id:
SARS2

# Metabolic_Enzyme_85_Geneatlas_id:
SARS2

# Metabolic_Enzyme_85_hgnc_id:
HGNC:17697

# Metabolic_Enzyme_85_PDB_ID:
Not Available

# Metabolic_Enzyme_85_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_85_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_85_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_85_Gene_Sequence:
>1557 bp
ATGGCTGCGTCCATGGCGCGGCGCTTGTGGCCTTTGCTGACTCGTCGGGGGTTCCGGCCC
CGGGGAGGCTGCATCTCCAACGATAGTCCAAGGAGAAGTTTCACTACAGAGAAACGAAAC
CGGAACCTCCTGTACGAGTATGCGCGCGAGGGCTACAGCGCACTCCCTCAGCTGGACATA
GAGCGGTTCTGCGCATGCCCAGAAGAGGCCGCACACGCCCTGGAGCTCCGCAAGGGGGAG
CTGCGCTCGGCGGACCTGCCCGCGATCATCTCGACATGGCAGGAGCTGAGGCAGCTGCAG
GAGCAGATCCGGAGCCTGGAGGAAGAGAAGGCAGCTGTGACTGAGGCAGTGCGGGCCCTG
CTGGCAAACCAGGACAGTGGTGAAGTGCAGCAGGACCCCAAGTACCAGGGTCTGCGGGCA
CGTGGCCGGGAGATCCGGAAGGAGCTTGTTCACCTGTACCCCAGGGAGGCCCAGCTTGAG
GAGCAGTTCTACCTGCAGGCGCTGAAGCTGCCCAACCAGACCCACCCAGACGTGCCCGTC
GGGGATGAGAGCCAGGCTCGAGTGCTCCACATGGTCGGAGACAAGCCAGTTTTCTCCTTC
CAACCTCGGGGCCACCTGGAAATTGGCGAGAAACTCGACATCATCCGTCAGAAGCGCCTG
TCCCACGTGTCTGGCCACCGGTCCTATTACCTGCGCGGGGCTGGAGCCCTCCTGCAGCAC
GGCCTGGTCAACTTCACATTCAACAAGCTTCTCCGCCGGGGCTTCACCCCCATGACGGTG
CCAGACCTTCTCCGCGGAGCAGTGTTTGAAGGCTGTGGGATGACACCAAATGCCAACCCA
TCCCAAATTTACAACATCGACCCTGCCCGCTTCAAAGATCTCAACCTGGCTGGAACAGCG
GAGGTGGGGCTTGCAGGCTACTTCATGGACCACACCGTGGCCTTCAGGGACCTGCCAGTC
AGGATGGTTTGCTCCAGCACCTGCTACCGGGCAGAGACAAACACGGGACAGGAACCCCGG
GGGCTGTATCGAGTACACCACTTCACCAAGGTGGAGATGTTTGGGGTGACAGGCCCTGGG
CTGGAGCAGAGCTCACAGCTGCTGGAGGAGTTCCTGTCCCTTCAGATGGAGATCTTGACA
GAGCTGGGCTTGCACTTCCGGGTCCTGGATATGCCCACCCAAGAACTGGGCCTCCCCGCC
TACCGCAAGTTTGACATTGAGGCCTGGATGCCAGGCCGAGGCCGCTTTGGAGAGGTCACC
AGTGCTTCCAACTGCACAGACTTCCAGAGCCGCCGCCTCCACATCATGTTCCAGACCGAG
GCTGGGGAGCTGCAGTTTGCCCACACGGTGAACGCCACCGCCTGTGCTGTCCCCCGCCTT
CTCATCGCGCTCCTGGAGAGTAACCAGCAGAAGGACGGCTCAGTGCTCGTGCCCCCTGCC
CTCCAGTCCTACCTCGGCACTGATCGGATCACAGCCCCTACCCACGTGCCTCTCCAGTAC
ATCGGCCCCAACCAGCCCCGGAAGCCTGGGCTGCCTGGCCAGCCTGCTGTAAGCTAA

# Metabolic_Enzyme_85_GenBank_ID_Gene:
AB029948

# Metabolic_Enzyme_85_Chromosome_Location:
Not Available

# Metabolic_Enzyme_85_Locus:
Not Available

# Metabolic_Enzyme_85_SNPs:
Not Available

# Metabolic_Enzyme_85_General_References:
10764807

# Metabolic_Enzyme_85_References:
Not Available

# Metabolic_Enzyme_86_ID:
5902

# Metabolic_Enzyme_86_Name:
High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

# Metabolic_Enzyme_86_Synonyms:
HSPDE8B

# Metabolic_Enzyme_86_Gene_Name:
PDE8B

# Metabolic_Enzyme_86_Protein_Sequence:
>Highaffinity cAMPspecific and IBMXinsensitive 3',5'cyclic phosphodiesterase 8
BMGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRAS
GPPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAE
VRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEI
IVIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFM
ENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFE
RMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHV
KITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESID
VKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVL
EILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPIT
INDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRA
WFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDH
PGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQA
IIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC
ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY
FITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS

# Metabolic_Enzyme_86_Number_of_Residues:
885

# Metabolic_Enzyme_86_Molecular_Weight:
98980

# Metabolic_Enzyme_86_Theoretical_pI:
6.81

# Metabolic_Enzyme_86_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  two-component response regulator activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  signal transducer activity
Function:  catalytic activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
Process:  two-component signal transduction system (phosphorelay)
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_86_General_Function:
Signal transduction mechanisms 

# Metabolic_Enzyme_86_Specific_Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase has high affinity for cAMP and may be involved in specific signaling in the thyroid gland

# Metabolic_Enzyme_86_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_86_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_86_Pfam_Domain_Function:
PF00989:PAS;
PF08629:PDE8;
PF00233:PDEase_I;
PF00072:Response_reg

# Metabolic_Enzyme_86_Signals:
None

# Metabolic_Enzyme_86_Transmembrane_Regions:
None

# Metabolic_Enzyme_86_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_86_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_86_GenBank_ID_Protein:
32261241

# Metabolic_Enzyme_86_SwissProt_ID:
PDE8B_HUMAN (O95263)

# Metabolic_Enzyme_86_swissprot_Name:
Not Available

# Metabolic_Enzyme_86_Genecard_id:
PDE8B

# Metabolic_Enzyme_86_Geneatlas_id:
PDE8B

# Metabolic_Enzyme_86_hgnc_id:
HGNC:8794

# Metabolic_Enzyme_86_PDB_ID:
Not Available

# Metabolic_Enzyme_86_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_86_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_86_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_86_Gene_Sequence:
>2517 bp
ATGGGCTGCGCCCCCAGCATCCATGTCTCGCAGAGCGGCGTGATCTACTGCCGGGACTCG
GACGAGTCCAGCTCGCCCCGCCAGACCACCAGCGTGTCGCAGGGCCCGGCGGCACCCCTG
CCCGGCCTCTTCGTCCAGACCGACGCCGCCGACGCCATCCCCCCGAGCCGCGCGTCGGGA
CCCCCCAGCGTAGCCCGCGTCCGCAGGGCCCGCACCGAGCTGGGCAGCGGTAGCAGCGCG
GGTTCCGCAGCCCCCGCCGCGACCACCAGCAGGGGCCGGAGGCGCCACTGCTGCAGCAGC
GCCGAGGCCGAGACTCAGACCTGCTACACCAGCGTGAAGCAGGTGTCTTCTGCGGAGGTG
CGCATCGGGCCCATGAGACTGACGCAGGACCCTATTCAGGTTTTGCTGATCTTTGCAAAG
GAAGATAGTCAGAGCGATGGCTTCTGGTGGGCCTGCGACAGAGCTGGTTATAGATGCAAT
ATTGCTCGGACTCCAGAGTCAGCCCTTGAATGCTTTCTTGATAAGCATCATGAAATTATT
GTAATTGATCATAGACAAACTCAGAACTTCGATGCAGAAGCAGTGTGCAGGTCGATCCGG
GCCACAAATCCCTCCGAGCACACGGTGATCCTCGCAGTGGTTTCGCGAGTATCGGATGAC
CATGAAGAGGCGTCAGTCCTTCCTCTTCTCCACGCAGGCTTCAACAGGAGATTTATGGAG
AATAGCAGCATAATTGCTTGCTATAATGAACTGATTCAAATAGAACATGGGGAAGTTCGC
TCCCAGTTCAAATTACGGGCCTGTAATTCAGTGTTTACAGCATTAGATCACTGTCATGAA
GCCATAGAAATAACAAGCGATGACCACGTGATTCAGGAGTGGCAGGGGGTTTACTATGCC
AGACGGAAATCCGGGGACAGCATCCAACAGCACGTGAAGATCACCCCAGTGATTGGCCAA
GGAGGGAAAATTAGGCATTTTGTCTCGCTCAAGAAACTGTGTTGTACCACTGACAATAAT
AAGCAGATTCACAAGATTCATCGTGATTCAGGAGATAATTCTCAGACAGAGCCTCATTCA
TTCAGATATAAGAACAGGAGGAAAGAGTCCATTGACGTGAAATCGATATCATCTCGAGGC
AGTGATGCACCAAGCCTGCAGAATCGTCGCTATCCGTCCATGGCGAGGATCCACTCCATG
ACCATCGAGGCTCCCATCACAAAGGTTATAAATATAATCAATGCAGCCCAAGAAAACAGC
CCAGTCACAGTAGCGGAAGCCTTGGACAGAGTTCTAGAGATTTTACGGACCACAGAACTG
TACTCCCCTCAGCTGGGTACCAAAGATGAAGATCCCCACACCAGTGATCTTGTTGGAGGC
CTGATGACTGACGGCTTGAGAAGACTGTCAGGAAACGAGTATGTGTTTACTAAGAATGTG
CACCAGAGTCACAGTCACCTTGCAATGCCAATAACCATCAATGATGTTCCCCCTTGTATC
TCTCAATTACTTGATAATGAGGAGAGTTGGGACTTCAACATCTTTGAATTGGAAGCCATT
ACGCATAAAAGGCCATTGGTTTATCTGGGCTTAAAGGTCTTCTCTCGGTTTGGAGTATGT
GAGTTTTTAAACTGTTCTGAAACCACTCTTCGGGCCTGGTTCCAAGTGATCGAAGCCAAC
TACCACTCTTCCAATGCCTACCACAACTCCACCCATGCTGCCGACGTCCTGCACGCCACC
GCTTTCTTTCTTGGAAAGGAAAGAGTAAAGGGAAGCCTCGATCAGTTGGATGAGGTGGCA
GCCCTCATTGCTGCCACAGTCCATGACGTGGATCACCCGGGAAGGACCAACTCTTTCCTC
TGCAATGCAGGCAGTGAGCTTGCTGTGCTCTACAATGACACTGCTGTTCTGGAGAGTCAC
CACACCGCCCTGGCCTTCCAGCTCACGGTCAAGGACACCAAATGCAACATTTTCAAGAAT
ATTGACAGGAACCATTATCGAACGCTGCGCCAGGCTATTATTGACATGGTTTTGGCAACA
GAGATGACAAAACACTTTGAACATGTGAATAAGTTTGTGAACAGCATCAACAAGCCAATG
GCAGCTGAGATTGAAGGCAGCGACTGTGAATGCAACCCTGCTGGGAAGAACTTCCCTGAA
AACCAAATCCTGATCAAACGCATGATGATTAAGTGTGCTGACGTGGCCAACCCATGCCGC
CCCTTGGACCTGTGCATTGAATGGGCTGGGAGGATCTCTGAGGAGTATTTTGCACAGACT
GATGAAGAGAAGAGACAGGGACTACCTGTGGTGATGCCAGTGTTTGACCGGAATACCTGT
AGCATCCCCAAGTCTCAGATCTCTTTCATTGACTACTTCATAACAGACATGTTTGATGCT
TGGGATGCCTTTGCACATCTACCAGCCCTGATGCAACATTTGGCTGACAACTACAAACAC
TGGAAGACACTAGATGACCTAAAGTGCAAAAGTTTGAGGCTTCCATCTGACAGCTAA

# Metabolic_Enzyme_86_GenBank_ID_Gene:
AY129948

# Metabolic_Enzyme_86_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_86_Locus:
5q14.1

# Metabolic_Enzyme_86_SNPs:
rs335614; rs971647; rs40594; rs459366; rs1061405; rs3733953; rs460267; rs16874261; rs832790; rs1479564; rs2046045; rs1479594; rs1479563; rs251421; rs335605; rs335643; rs844274; rs335644; rs875214; rs1531615; rs832788; rs832787; rs1904441; rs141331; rs890717; rs251420; rs2242159; rs884162; rs1096752; rs832785; rs251419; rs1479600; rs1871467; rs10473990; rs3797462; rs6867654; rs3733952; rs1545774; rs7715119; rs7717046; rs12697864; rs10056404; rs9686527; rs12521494; rs163017; rs11739402; rs4704402; rs1382879; rs7720828; rs6863296; rs922540; rs11960749; rs6887019; rs4704403; rs10066037; rs1560024; rs6885282; rs335599; rs1479598; rs6885813; rs335640; rs6860843; rs4704410; rs1382893; rs6893108; rs6453304; rs1479565; rs10942816; rs6874493; rs10474498; rs7717216; rs251426; rs12523314; rs374003; rs12516568; rs4704412; rs6864050; rs2242160; rs6453298; rs6453305; rs11953611; rs7729842; rs7732963; rs7714529; rs7705337; rs251418; rs922539; rs181851; rs4704417; rs4704397; rs12697863; rs6864358; rs7731628; rs7727976; rs11738226; rs1124742; rs11949597; rs13160107; rs3101867; rs1382894; rs1545775; rs10064824; rs2359877; rs7728597; rs4704414; rs10036386; rs251422; rs2279095; rs7733908; rs6860674; rs6453299; rs251416; rs1479562; rs6885099; rs10061629; rs10066802; rs10942819; rs4704409; rs12187512; rs10942817; rs16874184; rs7703993; rs7707719; rs951275; rs90684; rs11951639; rs335638; rs11956168; rs3816609; rs9293713; rs4704408; rs9686526; rs10213867; rs17683162; rs11738541; rs7718685; rs6453302; rs12520862; rs10474500; rs17570409; rs6886144; rs9687206; rs11745130; rs11738313; rs7702192; rs2359875; rs16874127; rs2859576; rs4704399; rs16874252; rs13436203; rs2359876; rs11747913; rs6453303; rs398509; rs251425; rs10942815; rs10514095; rs11744930; rs6453300; rs1982661; rs4704411; rs2359797; rs7723920; rs13355167; rs181852; rs6453296; rs11738417; rs11750528; rs2619770; rs6887671; rs6884413; rs16874241; rs11742966; rs7719378; rs11741219; rs10514096; rs970114; rs6892518; rs9687030; rs11957189; rs4596357; rs11742730; rs4704400; rs17671296; rs11959854; rs13158658; rs2306344; rs9942368; rs3101866; rs11748011; rs12515504; rs13361710; rs11749728; rs4704416; rs6861787; rs10045589; rs7448368; rs11748861; rs1479596; rs11741458; rs13164603; rs723374; rs335597; rs11749079; rs13178853; rs2884816; rs2359874; rs2306345; rs13158164; rs4703730; rs7713259; rs10514098; rs12514694; rs12515498; rs7716880; rs1479567; rs251428; rs10076794; rs10474493; rs1351283; rs335598; rs1479597; rs11750342; rs6453297; rs251414; rs2242161; rs1351284; rs11750661; rs11950697; rs251429; rs11956845; rs10514099; rs13182395; rs2046046; rs4703731; rs2061909; rs2359872; rs12522076; rs6896093; rs17750669; rs7711488; rs12513677; rs335618; rs90682; rs9686502; rs11750710; rs251430; rs7706106; rs1962690; rs90683; rs1479595; rs17671243; rs2170021; rs11741983; rs7704000; rs6870257; rs335616; rs6873924; rs989758; rs10037599; rs10069775; rs12658216; rs6862335; rs251417; rs13159632; rs7732150; rs12516965; rs6453301; rs6881121; rs12514649; rs12188039; rs864109; rs11949070; rs1993945; rs335642; rs13179491; rs1871466; rs183142; rs13186963; rs17683175; rs12658665; rs12189200; rs13179191; rs7710193; rs6871774; rs12652928; rs1479601; rs6881859; rs1993946; rs410656; rs13167306; rs13186807; rs6897771; rs11738860; rs9293711; rs16874254; rs4470750; rs10474499; rs11742634; rs6882455; rs2279094; rs35317395; rs7723017; rs16874217; rs4703732; rs6884627; rs11955381; rs13183278; rs16874125; rs2127387; rs10942818; rs11958816; rs16874147; rs1479599; rs6887282; rs9293716; rs9293712; rs4704398; rs13166933; rs13179196; rs6859326; rs10085063; rs3214046; rs7724067; rs10045594; rs17570416; rs6875758; rs10037785; rs7724077; rs2359873; rs16874198; rs6877581; rs11744847; rs17750729; rs2011799; rs7721608; rs4704401; rs6453295; rs13180935; rs10043551; rs9784696; rs251427; rs13186178; rs12515919; rs11749959; rs10474497; rs11741955; rs251413; rs11740409; rs12188903; rs6867719; rs13356848; rs7702923; rs2306343; rs16874239; rs7702029; rs6870261; rs7710509; rs13163022; rs173706; rs12188035; rs7719566; rs10474496; rs4704413; rs251431; rs7726487; rs17570031; rs1971620; rs6897909; rs13182285; rs6883526; rs6888919; rs17671405; rs6866018; rs6865817; rs13159287; rs7726243; rs335615; rs16874258; rs395882; rs17671389; rs12514448; rs10055027; rs10474495; rs13167302; rs6870862; rs10074631; rs13436637; rs12655629; rs6879904; rs17750688; rs6896812; rs10038311; rs10805909; rs11748016; rs335639; rs3816608; rs384871; rs7710224; rs10474494; rs7709849; rs12519528; rs186753; rs10536220; rs35454325; rs3733956; rs3733954; rs3733955; rs2017194; rs35747735; rs13163675; rs35577468; rs12153049; rs7714995; rs4704404; rs7735605; rs34790629; rs28409208; rs34299034; rs5868866; rs7714678; rs10039955; rs35428698; rs35884509; rs11745026; rs10474501; rs4432867; rs35554951; rs989759; rs10589971; rs36123024; rs35500936; rs1075970; rs13179037; rs11342716; rs251423; rs33976034; rs34191327; rs12233968; rs10474491; rs35235250; rs10591556; rs36022309; rs34566085; rs6858922; rs4704405; rs3926515; rs4521449; rs10608700; rs35742497; rs34717093; rs7717513; rs35601934; rs34988409; rs12520774; rs34128451; rs35350477; rs35358557; rs35681195; rs35858417; rs7714055; rs28622161; rs12515456; rs7356782; rs10085113; rs251424; rs35094296; rs1678771; rs36015907; rs34047268; rs17570395; rs11294329; rs34098762; rs34208297; rs3217712; rs34818611; rs34990832; rs3031820; rs33948936; rs34014902; rs34156142; rs5868864; rs34885670; rs34414970; rs35345614; rs11395504; rs16874135; rs12153424; rs11429258; rs35966684; rs13179071; rs6892493; rs28681499; rs3031818; rs28710929; rs35022674; rs34802194; rs11746782; rs11295108; rs35070029; rs11351004; rs35116180; rs34537187; rs34646527; rs1678770; rs35065656; rs1479566; rs34923412; rs10053760; rs35315780; rs35794220; rs11959580; rs34650604; rs33989497; rs10538529; rs5868867; rs35232100; rs35318083; rs2127393; rs35382869; rs34744319; rs2011227; rs34891839; rs335641; rs34698234; rs11316141; rs34336462; rs34713301; rs992807; rs11291697; rs10570712; rs34595584; rs335620; rs34465374; rs35914326; rs2359798; rs35785414; rs11284931; rs28431869; rs35786402; rs35981544; rs10552319; rs34318585; rs35164635; rs36052225; rs28527260; rs35776739; rs34491745; rs35910383; rs34720163; rs12521742; rs10645799; rs6860861; rs2306342; rs35407074; rs33938742; rs9687054; rs35870926; rs34731275; rs6871708; rs335617; rs7726528; rs41361846; rs35749456; rs34999521; rs28684701; rs35812985; rs1479568; rs13176017; rs34047237; rs35330679; rs35596621; rs6883469; rs35327743; rs13184182; rs5868865; rs3101235; rs6888937; rs34079916; rs35814560; rs35864749; rs10054725; rs3087185; rs34282242; rs6866209; rs34721887; rs13170449; rs34215321; rs6873097; rs35635069; rs33982217; rs832789; rs6875032; rs34708007; rs6894516; rs35839801; rs35156526; rs11422456; rs10036431; rs34725176; rs11418983; rs35535651; rs34142462; rs989757; rs36012253; rs35049636; rs34634450; rs6884434; rs35105712; rs34161143; rs4704406; rs11351800; rs33935667; rs3101236; rs34478659; rs34868740; rs34295093; rs11750129; rs35571993; rs173705; rs36011566; rs13158646; rs34152352; rs13179039; rs10076967; rs35309506; rs5868868; rs34081668; rs35776933; rs36021489; rs10589970; rs35120441; rs34017471; rs13159463; rs13174807; rs35159916; rs35280028; rs11405343; rs10602643; rs10573022; rs34410098; rs7443262; rs35717428; rs34922408; rs34773470; rs13158363; rs34420432; rs35470878; rs951276; rs35287095; rs34667262; rs251415; rs13170957; rs3031840; rs35452272; rs5868861; rs13166828; rs11958889; rs35160422; rs6866832; rs10710933; rs5868863; rs4704407; rs10552320; rs34684475; rs34735760; rs34540880; rs13166832; rs34008487; rs34960472; rs35010340; rs17671075; rs35522982; rs12523516; rs6884022; rs35185692; rs35363643; rs34748700; rs11413850; rs3031815; rs35838065; rs36085912; rs34764404; rs34648561; rs10639131; rs35674495; rs9942364; rs36120983; rs13166110; rs953375; rs35689253; rs34089667; rs13183146; rs5868860; rs7730446; rs5868862; rs13179043; rs35262504; rs35174935; rs12523538; rs35201094; rs35997618; rs35295164; rs35798710; rs35028488; rs35515495; rs35812799; rs9763156; rs2884817; rs4133658; rs2619784; rs34034632; rs34093656; rs35449293; rs13178574; rs34937443; rs35968667; rs335619; rs12110072; rs34525889; rs35052848; rs1045094; rs1111991; rs11739698; rs12652987; rs1382880; rs14368; rs1580; rs16874264; rs17671842; rs1982658; rs1982659; rs2114950; rs251411; rs251412; rs2928173; rs2972333; rs2972336; rs3149; rs335621; rs335622; rs335623; rs335624; rs335625; rs335627; rs335628; rs335629; rs335630; rs335631; rs335632; rs335633; rs335634; rs335635; rs335636; rs34489686; rs35189891; rs35774719; rs3797461; rs3797632; rs3797633; rs3797634; rs4704396; rs4704421; rs6864606; rs6891339; rs6898325; rs7726419; rs7737666; rs922538; rs972629; rs974280

# Metabolic_Enzyme_86_General_References:
12372422; 12681444; 9784418

# Metabolic_Enzyme_86_References:
Not Available

# Metabolic_Enzyme_87_ID:
5903

# Metabolic_Enzyme_87_Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C

# Metabolic_Enzyme_87_Synonyms:
DPDE1; PDE21

# Metabolic_Enzyme_87_Gene_Name:
PDE4C

# Metabolic_Enzyme_87_Protein_Sequence:
>cAMPspecific 3',5'cyclic phosphodiesterase 4
CMENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRER
DLSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRES
FLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLG
AAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKR
ILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHS
ASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDL
LKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEIL
AALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQN
LSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQ
NLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVG
FIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFE
LTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT

# Metabolic_Enzyme_87_Number_of_Residues:
712

# Metabolic_Enzyme_87_Molecular_Weight:
79902

# Metabolic_Enzyme_87_Theoretical_pI:
4.84

# Metabolic_Enzyme_87_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_87_General_Function:
Not Available

# Metabolic_Enzyme_87_Specific_Function:
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate

# Metabolic_Enzyme_87_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_87_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_87_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_87_Signals:
None

# Metabolic_Enzyme_87_Transmembrane_Regions:
None

# Metabolic_Enzyme_87_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_87_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_87_GenBank_ID_Protein:
727223

# Metabolic_Enzyme_87_SwissProt_ID:
PDE4C_HUMAN (Q08493)

# Metabolic_Enzyme_87_swissprot_Name:
Not Available

# Metabolic_Enzyme_87_Genecard_id:
PDE4C

# Metabolic_Enzyme_87_Geneatlas_id:
PDE4C

# Metabolic_Enzyme_87_hgnc_id:
HGNC:8782

# Metabolic_Enzyme_87_PDB_ID:
Not Available

# Metabolic_Enzyme_87_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_87_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_87_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_87_Gene_Sequence:
>2139 bp
ATGGAGAACCTGGGGGTCGGCGAAGGGGCAGAGGCTTGCAGCAGGTTGAGTCGCTCTCGC
GGCCGCCACAGCATGACCAGAGCCCCGAAGCACCTGTGGCGGCAACCCCGGCGCCCCATC
CGCATCCAACAGCGCTTCTATTCGGATCCGGACAAGTCCGCGGGCTGCCGCGAGAGGGAC
CTGAGCCCGCGGCCGGAGCTCAGGAAGTCGCGGCTCTCCTGGCCCGTTTCCTCCTGCAGG
CGCTTTGACCTGGAAAATGGGCTCTCGTGTGGGAGGAGGGCCCTGGACCCTCAGTCCAGC
CCTGGCCTGGGCCGGATTATGCAGGCTCCAGTCCCGCACAGCCAGCGGCGCGAGTCCTTC
CTGTACCGCTCAGATAGCGACTATGAACTCTCGCCCAAGGCCATGTCTCGGAACTCCTCT
GTGGCCAGCGACCTACATGGAGAGGACATGATTGTGACGCCCTTTGCCCAGGTCCTGGCC
AGTCTGCGGACCGTTCGGAGCAACGTGGCGGCCCTTGCCCGCCAGCAATGCCTAGGAGCA
GCCAAGCAGGGACCCGTCGGAAACCCTTCATCCAGCAATCAGCTCCCTCCTGCAGAGGAC
ACGGGGCAGAAGCTGGCATTGGAGACGCTAGACGAGCTGGACTGGTGCCTGGATCAGTTG
GAGACGCTGCAGACCCGGCACTCGGTGGGGGAGATGGCCTCCAACAAGTTCAAGCGGATC
CTGAACCGGGAGTTGACCCACCTGTCCGAAACCAGCCGCTCCGGGAACCAGGTGTCCGAG
TACATCTCCCGGACCTTCCTGGACCAGCAGACCGAGGTGGAGCTGCCCAAGGTGACCGCT
GAGGAGGCCCCACAGCCCATGTCCCGGATCAGTGGCCTACATGGGCTCTGCCACAGTGCC
AGCCTCTCCTCAGCCACTGTCCCACGCTTTGGGGTCCAGACTGACCAGGAGGAGCAACTG
GCCAAGGAGCTAGAAGACACCAACAAGTGGGGACTTGATGTGTTCAAGGTGGCGGACGTA
AGTGGGAACCGGCCCCTCACAGCTATCATATTCAGCATTTTTCAGGAGCGGGACCTGCTG
AAGACATTCCAGATCCCAGCAGACACACTGGCCACCTACCTGCTGATGCTGGAGGGTCAC
TACCACGCCAATGTGGCCTACCACAACAGCCTACATGCCGCCGACGTGGCCCAGTCCACG
CATGTGCTGCTGGCTACGCCCGCCCTCGAGGCTGTGTTCACAGACTTGGAAATCCTGGCT
GCCCTCTTTGCAAGCGCCATCCACGACGTGGACCATCCTGGGGTCTCCAACCAGTTTCTG
ATTAACACCAACTCAGACGTGGCGCTTATGTACAACGACGCCTCGGTGCTGGAGAACCAT
CACCTGGCTGTGGGCTTCAAGCTGCTGCAGGCAGAGAACTGCGATATCTTCCAGAACCTC
AGCGCCAAGCAGCGACTGAGTCTGCGCAGGATGGTCATTGACATGGTGCTGGCCACAGAC
ATGTCCAAACACATGAACCTCCTGGCCGACCTCAAGACCATGGTGGAGACCAAGAAGGTG
ACAAGCCTCGGTGTCCTCCTCCTGGACAACTATTCCGACCGAATCCAGGTCTTGCAGAAC
CTGGTGCACTGTGCTGATCTGAGCAACCCCACCAAGCCGCTGCCCCTGTACCGCCAGTGG
ACGGACCGCATCATGGCCGAGTTCTTCCAGCAGGGAGACCGCGAGCGTGAGTCGGGCCTG
GACATCAGTCCCATGTGTGACAAGCATACGGCCTCAGTGGAGAAGTCCCAGGTGGGTTTC
ATTGACTACATTGCTCACCCACTGTGGGAGACTTGGGCTGACCTGGTCCACCCAGATGCA
CAGGACCTGCTGGACACGCTGGAGGACAATCGAGAGTGGTACCAGAGCAAGATCCCCCGA
AGTCCCTCAGACCTCACCAACCCCGAGCGGGACGGGCCTGACAGATTCCAGTTTGAACTG
ACTCTGGAGGAGGCAGAGGAAGAGGATGAGGAGGAAGAAGAGGAGGGGGAAGAGACAGCT
TTAGCCAAAGAGGCCTTGGAGTTGCCTGACACTGAACTCCTGTCCCCTGAAGCCGGCCCA
GACCCTGGGGACTTACCCCTCGACAACCAGAGGACTTAG

# Metabolic_Enzyme_87_GenBank_ID_Gene:
Z46632

# Metabolic_Enzyme_87_Chromosome_Location:
Not Available

# Metabolic_Enzyme_87_Locus:
Not Available

# Metabolic_Enzyme_87_SNPs:
Not Available

# Metabolic_Enzyme_87_General_References:
7843419; 10574328; 8413254

# Metabolic_Enzyme_87_References:
Not Available

# Metabolic_Enzyme_88_ID:
5904

# Metabolic_Enzyme_88_Name:
Ribose-phosphate pyrophosphokinase II

# Metabolic_Enzyme_88_Synonyms:
Phosphoribosyl pyrophosphate synthetase II; PRS-II; PPRibP

# Metabolic_Enzyme_88_Gene_Name:
PRPS2

# Metabolic_Enzyme_88_Protein_Sequence:
>Ribosephosphate pyrophosphokinase 
IIMPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQS
GCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSV
AGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRV
TSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLS
AGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAE
AIRRTHNGESVSYLFSHVPL

# Metabolic_Enzyme_88_Number_of_Residues:
318

# Metabolic_Enzyme_88_Molecular_Weight:
34770

# Metabolic_Enzyme_88_Theoretical_pI:
6.60

# Metabolic_Enzyme_88_GO_Classification:
>>>
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  lipoate-protein ligase activity
Function:  lipoate-protein ligase B activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  diphosphotransferase activity
Function:  ribose phosphate diphosphokinase activity
 ||
>>>
Process:  nucleotide biosynthesis
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleoside monophosphate metabolism
Process:  nucleoside monophosphate biosynthesis
Process:  ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_88_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_88_Specific_Function:
ATP + D-ribose 5-phosphate = AMP + 5-phospho- alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_88_Pathway:
map00030  Pentose phosphate pathway;
 map00230  Purine metabolism

# Metabolic_Enzyme_88_Reaction:
ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_88_Pfam_Domain_Function:
PF00156:Pribosyltran

# Metabolic_Enzyme_88_Signals:
None

# Metabolic_Enzyme_88_Transmembrane_Regions:
None

# Metabolic_Enzyme_88_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_88_EC_Link:
EC 2.7.6.1

# Metabolic_Enzyme_88_GenBank_ID_Protein:
35700

# Metabolic_Enzyme_88_SwissProt_ID:
PRPS2_HUMAN (P11908)

# Metabolic_Enzyme_88_swissprot_Name:
Not Available

# Metabolic_Enzyme_88_Genecard_id:
PRPS2

# Metabolic_Enzyme_88_Geneatlas_id:
PRPS2

# Metabolic_Enzyme_88_hgnc_id:
HGNC:9465

# Metabolic_Enzyme_88_PDB_ID:
Not Available

# Metabolic_Enzyme_88_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_88_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_88_Subcellular_Location:
Not Available

# Metabolic_Enzyme_88_Gene_Sequence:
>957 bp
ATGCCCAACATCGTGCTGTTCAGCGGCAGCTCGCATCAGGACCTATCCCAGCGCGTGGCC
GACCGCCTGGGCCTGGAGCTGGGCAAGGTGGTCACGAAGAAGTTCAGCAACCAGGAGACC
AGCGTGGAGATTGGTGAAAGCGTGAGAGGGGAAGATGTCTACATCATCCAGAGCGGCTGC
GGGGAAATTAACGACAACCTGATGGAACTCCTCATCATGATCAATGCCTGCAAGATTGCG
TCATCATCCAGAGTAACTGCCGTGATCCCGTGTTTCCCATACGCCCGACAAGATAAAAAG
GACAAGAGTCGTGCCCCAATTTCTGCAAAACTTGTGGCCAATATGCTGTCGGTGGCTGGG
GCGGATCACATCATCACCATGGACCTGCATGCTTCTCAGATACAGGGATTCTTTGATATT
CCTGTGGATAATTTGTATGCGGAGCCCGCAGTCCTGCAGTGGATTCGGGAAAACATTGCC
GAGTGGAAGAACTGTATCATTGTTTCACCTGACGCAGGGGGAGCCAAAAGGGTTACATCA
ATTGCAGACAGGTTGAATGTGGAATTTGCTTTGATCCACAAAGAGAGGAAGAAGGCGAAT
GAAGTGGACCGGATGGTCCTGGTGGGCGACGTGAAGGACCGTGTGGCCATCCTCGTGGAT
GACATGGCTGACACTTGCGGCACCATCTGCCATGCTGCGGACAAGCTGCTGTCAGCTGGA
GCCACCAAAGTGTATGCTATCCTTACCCATGGGATCTTCTCTGGACCAGCTATTTCCAGA
ATAAATAATGCCGCCTTTGAGGCTGTTGTCGTCACAAACACAATTCCGCAAGAGGACAAA
ATGAAACACTGCACCAAGATTCAGGTCATTGACATTTCCATGATCTTGGCCGAAGCAATC
CGAAGGACACACAATGGGGAATCCGTGTCCTACCTGTTCAGCCATGTCCCGCTATAA

# Metabolic_Enzyme_88_GenBank_ID_Gene:
Y00971

# Metabolic_Enzyme_88_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_88_Locus:
Xp22.3-p22.2

# Metabolic_Enzyme_88_SNPs:
rs1731469; rs2239490; rs917580; rs1638614; rs7062536; rs1266347; rs4830803; rs1638616; rs2284110; rs2239489; rs5935399; rs1266348; rs1731463; rs1269016; rs1731460; rs5979742; rs3815366; rs1638615; rs6639224; rs2699997; rs5979739; rs5934038; rs1632295; rs10521629; rs6639223; rs1638617; rs5979741; rs17281523; rs12558125; rs1731468; rs2284108; rs6641111; rs1638619; rs6641108; rs764646; rs2267489; rs2284106; rs12008243; rs7881129; rs6641109; rs2267488; rs4639691; rs16998972; rs2284105; rs7878770; rs4118335; rs1638613; rs17256004; rs2284102; rs5935397; rs6639222; rs2284101; rs7892586; rs1638612; rs1731470; rs11542625; rs11542626; rs1062629; rs16998976; rs6641113; rs41304713; rs5978578; rs7059565; rs12836621; rs2407939; rs10559509; rs12690195; rs5901489; rs34145657; rs5979740; rs1627037; rs35240522; rs12689006; rs7059902; rs2897808; rs2407938; rs10643414; rs1266349; rs3216443; rs5978580; rs2284104; rs12687586; rs6641101; rs35158521; rs12854516; rs36065243; rs5979737; rs7050147; rs6641100; rs41305175; rs6641102; rs10126562; rs7055278; rs6654965; rs2302266; rs2284109; rs5978579; rs7892044; rs35045468; rs5979738; rs34239644; rs35450855; rs3932785; rs12862297; rs12396877; rs12116138; rs41311801; rs34397079; rs1266365; rs1406788; rs1638607; rs1638608; rs1638610; rs1731471; rs1731474; rs1731475; rs17328218; rs2162; rs5934039; rs5979734; rs5979744; rs5979746; rs5979748; rs6641115; rs6641116

# Metabolic_Enzyme_88_General_References:
2538352; 2560337; 1314091

# Metabolic_Enzyme_88_References:
Not Available

# Metabolic_Enzyme_89_ID:
5266

# Metabolic_Enzyme_89_Name:
Acetyl-coenzyme A synthetase, cytoplasmic

# Metabolic_Enzyme_89_Synonyms:
Acetate--CoA ligase; Acyl-activating enzyme; Acetyl-CoA synthetase; ACS; AceCS; Acyl-CoA synthetase short-chain family member 2

# Metabolic_Enzyme_89_Gene_Name:
ACSS2

# Metabolic_Enzyme_89_Protein_Sequence:
>Acetylcoenzyme A synthetase, cytoplasmic
MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPRE
FWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDK
VAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLAC
ARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK
GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDEC
EPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIG
WITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFG
DEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPG
ATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTY
FKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVV
GHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSG
KIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ

# Metabolic_Enzyme_89_Number_of_Residues:
701

# Metabolic_Enzyme_89_Molecular_Weight:
78580

# Metabolic_Enzyme_89_Theoretical_pI:
6.43

# Metabolic_Enzyme_89_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  AMP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-sulfur bonds
Function:  CoA-ligase activity
Function:  acetate-CoA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_89_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_89_Specific_Function:
Activates acetate so that it can be used for lipid synthesis or for energy generation

# Metabolic_Enzyme_89_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_89_Reaction:
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

# Metabolic_Enzyme_89_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_89_Signals:
None

# Metabolic_Enzyme_89_Transmembrane_Regions:
None

# Metabolic_Enzyme_89_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_89_EC_Link:
EC 6.2.1.1

# Metabolic_Enzyme_89_GenBank_ID_Protein:
8439651

# Metabolic_Enzyme_89_SwissProt_ID:
ACSA_HUMAN (Q9NR19)

# Metabolic_Enzyme_89_swissprot_Name:
Not Available

# Metabolic_Enzyme_89_Genecard_id:
ACSS2

# Metabolic_Enzyme_89_Geneatlas_id:
ACSS2

# Metabolic_Enzyme_89_hgnc_id:
HGNC:15814

# Metabolic_Enzyme_89_PDB_ID:
Not Available

# Metabolic_Enzyme_89_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_89_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_89_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_89_Gene_Sequence:
>2106 bp
ATGGGGCTTCCTGAGGAGCGGGTCCGGAGCGGCAGCGGGAGCCGGGGCCAGGAGGAAGCT
GGAGCCGGAGGCCGGGCGCGGAGTTGGTCTCCGCCGCCCGAGGTCAGCCGCTCCGCGCAC
GTCCCCTCGCTGCAGCGCTACCGCGAGCTGCACCGGCGCTCCGTGGAGGAGCCGCGGGAA
TTCTGGGGAGACATTGCCAAGGAATTTTACTGGAAGACTCCATGCCCTGGCCCATTCCTT
CGGTACAACTTTGATGTGACTAAAGGGAAAATCTTCATTGAGTGGATGAAAGGAGCAACT
ACCAACATCTGCTACAATGTACTGGATCGAAATGTCCATGAGAAAAAGCTTGGAGATAAA
GTTGCTTTTTACTGGGAGGGCAATGAGCCAGGGGAGACCACTCAGATCACATACCATCAG
CTTCTGGTCCAAGTGTGTCAGTTCAGCAATGTTCTCCGAAAACAGGGCATTCAGAAGGGG
GACCGAGTGGCCATCTACATGCCTATGATCCCAGAGCTTGTGGTGGCCATGCTGGCATGT
GCCCGCATTGGGGCTTTGCACTCCATTGTGTTTGCAGGCTTCTCTTCAGAGTCTCTATGT
GAACGGATCTTGGATTCCAGCTGCAGTCTTCTCATCACTACAGATGCCTTCTACAGGGGG
GAAAAGCTTGTGAACCTGAAGGAGCTGGCTGACGAGGCCCTGCAGAAGTGTCAGGAGAAG
GGTTTCCCAGTAAGATGCTGCATTGTGGTCAAGCACCTGGGGCGGGCAGAGCTCGGCATG
GGTGACTCCACCAGCCAGTCCCCCCCAATTAAGAGGTCATGCCCAGATGTGCAGATCTCA
TGGAACCAAGGGATTGACTTGTGGTGGCATGAGCTCATGCAAGAGGCAGGGGATGAGTGT
GAGCCCGAGTGGTGTGATGCCGAGGACCCACTCTTCATCCTGTACACCAGTGGCTCCACA
GGCAAACCCAAGGGTGTGGTTCACACAGTTGGGGGCTACATGCTCTATGTAGCCACAACC
TTCAAGTATGTGTTTGACTTCCATGCAGAGGATGTGTTCTGGTGCACGGCAGACATTGGT
TGGATCACTGGTCATTCCTACGTCACCTATGGGCCACTGGCCAATGGTGCCACCAGTGTT
TTGTTTGAGGGGATTCCCACATATCCGGACGTGAACCGCCTGTGGAGCATTGTGGACAAA
TACAAGGTGACCAAGTTCTACACAGCACCCACAGCCATCCGTCTGCTCATGAAGTTTGGA
GATGAGCCTGTCACCAAGCATAGCCGGGCATCCTTGCAGGTGTTAGGCACAGTGGGTGAA
CCCATCAACCCTGAGGCCTGGCTATGGTACCACCGGGTGGTAGGTGCCCAGCGCTGCCCC
ATCGTGGACACCTTCTGGCAAACAGAGACAGGTGGCCACATGTTGACTCCCCTTCCTGGT
GCCACACCCATGAAACCCGGTTCTGCTACTTTCCCATTCTTTGGTGTAGCTCCTGCAATC
CTGAATGAGTCCGGGGAAGAGTTGGAAGGTGAAGCTGAAGGTTATCTGGTGTTCAAGCAG
CCCTGGCCAGGGATCATGCGCACAGTCTATGGGAACCACGAACGCTTTGAGACAACCTAC
TTTAAGAAGTTTCCTGGATACTATGTTACAGGAGATGGCTGCCAGCGGGACCAGGATGGC
TATTACTGGATCACTGGCAGGATTGATGACATGCTCAATGTATCTGGACACCTGCTGAGT
ACAGCAGAGGTGGAGTCAGCACTTGTGGAACATGAGGCTGTTGCAGAGGCAGCTGTGGTG
GGCCACCCTCATCCTGTGAAGGGTGAATGCCTCTACTGCTTTGTCACCTTGTGTGATGGC
CACACCTTCAGCCCCAAGCTCACCGAGGAGCTCAAGAAGCAGATTAGAGAAAAGATTGGC
CCCATTGCCACACCAGACTACATCCAGAATGCACCTGGCTTGCCTAAAACCCGCTCAGGG
AAAATCATGAGGCGAGTGCTTCGGAAGATTGCTCAGAATGACCATGACCTCGGGGACATG
TCTACTGTGGCTGACCCATCTGTCATCAGTCACCTCTTCAGCCACCGCTGCCTGACCATC
CAGTGA

# Metabolic_Enzyme_89_GenBank_ID_Gene:
AF263614

# Metabolic_Enzyme_89_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_89_Locus:
20q11.22

# Metabolic_Enzyme_89_SNPs:
rs4911163; rs10485507; rs6120750; rs1013677; rs6088635; rs6579198; rs6058135; rs6087642; rs6087641; rs6088638; rs6088636; rs7509557; rs6088650; rs6087644; rs6120758; rs4911164; rs6060112; rs8119110; rs6120763; rs6087649; rs6058137; rs3746450; rs4911447; rs6088640; rs1060615; rs6119542; rs926734; rs8116657; rs4911451; rs6119543; rs6120757; rs4911449; rs6088646; rs2295097; rs6087643; rs2223881; rs6088642; rs8117380; rs2273683; rs8123210; rs11905770; rs2064454; rs2076667; rs12717838; rs3818273; rs3787215; rs2207147; rs6120754; rs4911450; rs7266550; rs4911448; rs2378294; rs8125240; rs2378291; rs17092174; rs2378292; rs6058142; rs6120756; rs3787214; rs6120753; rs17092163; rs17092169; rs6060107; rs6060113; rs2378293; rs8117491; rs6120759; rs6088647; rs17850882; rs6088649; rs4349415; rs13043365; rs2295096; rs34527271; rs13043347; rs35779501; rs3053923; rs35596631; rs6088637; rs8115733; rs7509556; rs2024634; rs11476807; rs6060105; rs11472785; rs2024633; rs11467604; rs6120749; rs35991119; rs1062891; rs2024632; rs11167247; rs17400522; rs11699241; rs11472114; rs36077883; rs13042631; rs34362920; rs35104294; rs6119540; rs11478163; rs6088651; rs2295095; rs9547; rs11299664; rs6142261; rs35620674; rs35540450; rs6060111; rs3054612; rs6120752; rs11479533; rs34171408; rs11425079; rs6142260; rs34872018; rs11697404; rs11481649; rs7268774; rs34951413; rs33930398; rs6087647; rs34277751; rs6119544; rs35456894; rs6120764; rs6087646; rs11476381; rs11479477; rs28878236; rs6142263; rs6058143; rs5841186; rs28802941; rs8119835; rs6058136; rs3054610; rs6120755; rs28434523; rs35234476; rs8184664; rs11474295; rs35208311; rs34525778; rs36108141; rs34213461; rs6142258; rs2378290; rs6088639; rs6060110; rs6088643; rs36102262; rs11699164; rs35470839; rs35962008; rs6142259; rs11421679; rs10542624; rs8183627; rs6142255; rs34682859; rs35504652; rs11474981; rs6060106; rs6060115; rs35655449; rs34939273; rs11482260; rs4588263; rs34590082; rs13038710; rs6120760; rs6058138; rs6058139; rs35212956; rs35067244; rs6088645; rs6060108; rs11483997; rs11477769; rs4600736; rs7260994; rs6142256; rs11479348; rs6120761; rs6141520; rs6087645; rs13044142; rs34680118; rs11481648; rs35773172; rs13339938; rs36019966; rs35404681; rs6142257; rs13038395; rs13040750; rs5841185; rs34109099; rs35829893; rs34032248; rs13041047; rs11476265; rs41287074; rs11469541; rs6088641; rs35102137; rs6142254; rs34578238; rs10554596; rs34807244; rs6119541; rs28694099; rs34675937; rs34401220; rs6120751; rs35359973; rs6060109; rs6060104; rs17309872; rs2064453; rs2236270; rs2236271; rs6060103; rs6087651; rs6088628; rs6088629; rs6088631; rs6088652; rs725521; rs7263157; rs7264920; rs7265109; rs7265992; rs7269682

# Metabolic_Enzyme_89_General_References:
10843999; 11780052

# Metabolic_Enzyme_89_References:
Not Available

# Metabolic_Enzyme_90_ID:
5905

# Metabolic_Enzyme_90_Name:
Thiamin pyrophosphokinase 1

# Metabolic_Enzyme_90_Synonyms:
Thiamine pyrophosphokinase 1; hTPK1; Placental protein 20; PP20

# Metabolic_Enzyme_90_Gene_Name:
TPK1

# Metabolic_Enzyme_90_Protein_Sequence:
>Thiamin pyrophosphokinase 1
MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGER
ESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVD
VIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEG
DWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMA
IKS

# Metabolic_Enzyme_90_Number_of_Residues:
243

# Metabolic_Enzyme_90_Molecular_Weight:
27266

# Metabolic_Enzyme_90_Theoretical_pI:
4.82

# Metabolic_Enzyme_90_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  thiamin diphosphokinase activity
 ||
>>>
Process:  cofactor metabolism
Process:  coenzyme metabolism
Process:  coenzyme biosynthesis
Process:  thiamin diphosphate biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  vitamin metabolism
Process:  water-soluble vitamin metabolism
Process:  thiamin and derivative metabolism
Process:  thiamin metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_90_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_90_Specific_Function:
Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate

# Metabolic_Enzyme_90_Pathway:
map00730  Thiamine metabolism

# Metabolic_Enzyme_90_Reaction:
ATP + thiamine = AMP + thiamine diphosphate

# Metabolic_Enzyme_90_Pfam_Domain_Function:
PF04265:TPK_B1_binding;
PF04263:TPK_catalytic

# Metabolic_Enzyme_90_Signals:
None

# Metabolic_Enzyme_90_Transmembrane_Regions:
None

# Metabolic_Enzyme_90_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_90_EC_Link:
EC 2.7.6.2

# Metabolic_Enzyme_90_GenBank_ID_Protein:
12248915

# Metabolic_Enzyme_90_SwissProt_ID:
TPK1_HUMAN (Q9H3S4)

# Metabolic_Enzyme_90_swissprot_Name:
Not Available

# Metabolic_Enzyme_90_Genecard_id:
TPK1

# Metabolic_Enzyme_90_Geneatlas_id:
TPK1

# Metabolic_Enzyme_90_hgnc_id:
HGNC:17358

# Metabolic_Enzyme_90_PDB_ID:
1IG3

# Metabolic_Enzyme_90_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_90_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_90_Subcellular_Location:
Not Available

# Metabolic_Enzyme_90_Gene_Sequence:
>732 bp
ATGGAGCATGCCTTTACCCCGTTGGAGCCCCTGCTTTCCACTGGGAATTTGAAGTACTGC
CTTGTAATTCTTAATCAGCCTTTGGACAACTATTTTCGTCATCTTTGGAACAAAGCTCTT
TTAAGAGCCTGTGCCGATGGAGGTGCCAACCGCTTATATGATATCACCGAAGGAGAGAGA
GAAAGCTTTTTGCCTGAATTCATCAATGGAGACTTTGATTCTATTAGGCCTGAAGTCAGA
GAATACTATGCTACTAAGGGATGTGAGCTCATTTCAACTCCTGATCAAGACCACACTGAC
TTTACTAAGTGCCTTAAAATGCTCCAAAAGAAGATAGAAGAAAAAGACTTAAAGGTTGAT
GTGATCGTGACACTGGGAGGCCTTGCTGGGCGTTTTGACCAGATTATGGCATCTGTGAAT
ACCTTGTTCCAAGCGACTCACATCACTCCTTTTCCAATTATAATAATCCAAGAGGAATCG
CTGATCTACCTGCTCCAACCAGGAAAGCACAGGTTGCATGTAGACACTGGAATGGAGGGT
GATTGGTGTGGCCTTATTCCTGTTGGACAGCCTTGTATGCAGGTTACAACCACAGGCCTC
AAGTGGAACCTCACAAATGATGTGCTTGCTTTTGGAACATTGGTCAGTACTTCCAATACC
TACGACGGGTCTGGTGTTGTGACTGTGGAAACTGACCACCCACTCCTCTGGACCATGGCC
ATCAAAAGCTAA

# Metabolic_Enzyme_90_GenBank_ID_Gene:
AB028138

# Metabolic_Enzyme_90_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_90_Locus:
7q34-q35

# Metabolic_Enzyme_90_SNPs:
rs1731108; rs726068; rs228582; rs1731095; rs1635363; rs2371549; rs41242; rs969356; rs1731096; rs714429; rs1860265; rs994418; rs41244; rs1476612; rs1406720; rs1987569; rs228581; rs2057868; rs1406719; rs228587; rs1635357; rs962779; rs1635359; rs1629687; rs1731119; rs40228; rs1621146; rs2056811; rs1731098; rs6464587; rs6979902; rs1612172; rs7788824; rs1635349; rs6953870; rs7778973; rs765811; rs6464609; rs41238; rs10250170; rs12535171; rs7810658; rs6976763; rs2371551; rs11981245; rs7781839; rs6961123; rs1731114; rs6963694; rs10085379; rs7807524; rs228578; rs4563807; rs6464610; rs7805109; rs41241; rs7802389; rs10265577; rs11983652; rs2189529; rs4726716; rs6946827; rs6959326; rs10952584; rs4141299; rs6960462; rs10276866; rs886469; rs6973206; rs6958347; rs1635354; rs9640426; rs41237; rs6973145; rs6949066; rs6464592; rs6464603; rs1635355; rs1635352; rs41243; rs5000945; rs7793227; rs7785647; rs7791540; rs10275875; rs6464588; rs6946690; rs6964237; rs10231525; rs721492; rs1406717; rs10247371; rs2371550; rs11972593; rs7804157; rs1406721; rs1731091; rs7792485; rs10233851; rs1625341; rs1074710; rs10272083; rs12703604; rs6965642; rs6464602; rs6464607; rs10231147; rs1622877; rs6464595; rs10249863; rs1635344; rs6954594; rs10952581; rs7455032; rs2158370; rs228584; rs6946166; rs7788339; rs6951723; rs6464598; rs7779534; rs11772094; rs1731101; rs10261806; rs6973390; rs10248004; rs1320822; rs757387; rs10257572; rs1731109; rs6954373; rs10952579; rs7807442; rs6951849; rs717885; rs7805061; rs6464608; rs7793033; rs6966303; rs4725658; rs4726707; rs6948399; rs1731105; rs2888075; rs6974629; rs10268309; rs7806323; rs11980724; rs6967455; rs7803486; rs6942497; rs2040898; rs1476625; rs885680; rs4726719; rs2371641; rs10241699; rs1618538; rs10952582; rs6977069; rs1860266; rs6464589; rs10237837; rs228577; rs10155925; rs6956531; rs4725653; rs11977858; rs6464590; rs7784291; rs4329196; rs2189909; rs7787855; rs10245384; rs7787183; rs11977126; rs7781953; rs6464605; rs10274162; rs6945905; rs6962350; rs6464597; rs13226218; rs992007; rs7796878; rs7801499; rs6946458; rs7777827; rs6979644; rs1406718; rs1635329; rs10251353; rs10258069; rs10487633; rs6464611; rs1320824; rs7357183; rs9648815; rs1731100; rs12703608; rs13437960; rs6957904; rs1320820; rs4726713; rs10487637; rs11975166; rs6464617; rs6464606; rs11983252; rs6957154; rs1623765; rs10500141; rs962778; rs10487634; rs7811469; rs4016354; rs10251902; rs6464616; rs17171057; rs6950704; rs7778089; rs7790675; rs7781909; rs1074318; rs6946454; rs17170969; rs194201; rs1731117; rs17169931; rs6464600; rs1635364; rs6976400; rs7802963; rs10224675; rs2056809; rs1074317; rs6968395; rs17169957; rs6464601; rs6972416; rs6464613; rs17170719; rs13228902; rs2189738; rs2189910; rs10487627; rs17170035; rs1635336; rs6945036; rs16883123; rs6464599; rs7808484; rs11977606; rs6967058; rs11976010; rs17170233; rs17170200; rs6951021; rs6961444; rs12703600; rs17170231; rs10952580; rs7798810; rs10255314; rs11975203; rs2699471; rs4446660; rs10243407; rs6961679; rs10234573; rs7810222; rs6978100; rs9648817; rs17170003; rs4371917; rs17170146; rs11970836; rs10230359; rs10266203; rs10952585; rs6943480; rs717884; rs6975998; rs6464615; rs4726706; rs10269062; rs17170034; rs11976655; rs6969058; rs12673185; rs13438549; rs13225630; rs17170295; rs4726711; rs17170078; rs17169930; rs11976835; rs11971703; rs11979362; rs10155967; rs3779088; rs10487631; rs7801694; rs17287011; rs4377875; rs994417; rs10487628; rs7781216; rs1320821; rs6946391; rs6464612; rs10487629; rs7801925; rs2189528; rs6976745; rs885679; rs2699469; rs11980517; rs10247940; rs11762292; rs7795072; rs7777512; rs17170270; rs10487635; rs11983061; rs7779949; rs17286117; rs11983686; rs7792518; rs12674073; rs12703605; rs11973993; rs228580; rs10232406; rs13228129; rs6946334; rs10223964; rs2158371; rs4725657; rs7791450; rs6956364; rs1406715; rs6954142; rs13232295; rs10487639; rs11977370; rs11768341; rs10253585; rs17171133; rs6957906; rs7779650; rs4726712; rs1320823; rs10280828; rs6464619; rs6974413; rs10224766; rs1731102; rs10268282; rs13240754; rs17171050; rs1635353; rs7781374; rs194200; rs228579; rs17170428; rs6942964; rs7801730; rs10231234; rs7791757; rs17170937; rs6966886; rs10271250; rs13223054; rs12703602; rs6972897; rs7780527; rs10487636; rs1547941; rs194202; rs6464618; rs2016609; rs1320825; rs10952583; rs10155825; rs6464593; rs964543; rs10281363; rs11762493; rs13245975; rs7803779; rs17170239; rs17169940; rs11978358; rs13438381; rs1635337; rs10229938; rs11978026; rs7790937; rs6975570; rs17170241; rs6956805; rs1635330; rs11766638; rs11974303; rs9640427; rs6955318; rs10247508; rs4726708; rs6464604; rs6464614; rs11979143; rs6968016; rs1007808; rs10234455; rs6958412; rs17169892; rs12671701; rs7783309; rs10241043; rs4392812; rs17209471; rs10230676; rs17169947; rs10272856; rs34724570; rs1635327; rs3779087; rs7809233; rs10264530; rs11765297; rs17209934; rs6969194; rs10215525; rs12533896; rs12703603; rs6464596; rs11973750; rs17170268; rs7785771; rs11976994; rs10250843; rs7799129; rs6973189; rs9648818; rs2699470; rs10215110; rs10260560; rs7784829; rs17170503; rs13237512; rs6952569; rs7810675; rs10231848; rs6975789; rs17170427; rs12666981; rs17170186; rs17170132; rs17170974; rs17170570; rs2005737; rs11773654; rs17170294; rs11769730; rs10247674; rs6974568; rs10240509; rs13228589; rs17170947; rs10225456; rs17170023; rs10215993; rs17170343; rs964544; rs1731111; rs6955032; rs7785284; rs11978854; rs1731099; rs7801322; rs17170507; rs6970944; rs1731118; rs12703607; rs10215445; rs10248143; rs7792383; rs10239036; rs6960039; rs12703620; rs11981756; rs6945262; rs10257344; rs10272207; rs13239232; rs11765254; rs7804254; rs10253185; rs2191034; rs10271239; rs10228971; rs10266578; rs12703597; rs10272031; rs10251905; rs6949326; rs7811618; rs7803304; rs12531082; rs17170766; rs990282; rs10227041; rs10261059; rs12667412; rs10280074; rs10225702; rs11975258; rs17170559; rs10257169; rs11978625; rs35105540; rs13438458; rs11979997; rs2888111; rs9691233; rs13438291; rs6951713; rs228583; rs17170990; rs6974499; rs7779856; rs6972950; rs10281473; rs7785126; rs10267573; rs41239; rs17170938; rs10215111; rs10280337; rs6973103; rs7800275; rs7806373; rs6976709; rs12667225; rs1611032; rs1635346; rs17291130; rs11974334; rs7799740; rs9632633; rs7809179; rs1731103; rs1731110; rs13437950; rs11982835; rs17170383; rs17170347; rs10242149; rs17170388; rs1635360; rs1731113; rs10227237; rs6959699; rs2371637; rs17170235; rs10234583; rs17170275; rs10952586; rs7785427; rs7797321; rs6959248; rs10241983; rs34833212; rs10241064; rs1635334; rs12703621; rs6971870; rs10253757; rs11973170; rs2888081; rs6954171; rs17288242; rs7807606; rs10229168; rs17170147; rs10155929; rs1731106; rs17170707; rs6963794; rs11977307; rs10269087; rs7805891; rs11761020; rs1731097; rs11772882; rs12540950; rs6962462; rs1731116; rs10252412; rs17170582; rs1635331; rs7805122; rs7798962; rs11974301; rs17170536; rs10225581; rs10267437; rs6975988; rs6977886; rs10231108; rs11983131; rs10273397; rs7792324; rs10235829; rs10278788; rs1635347; rs6953807; rs886470; rs185268; rs7789621; rs10270534; rs10265933; rs7792794; rs1635345; rs10271097; rs10257797; rs7782138; rs10256458; rs10232425; rs6942765; rs7805437; rs10246963; rs4726714; rs10487641; rs17170274; rs12535518; rs6946929; rs7798949; rs228585; rs7802449; rs6973229; rs11975020; rs6962117; rs6964316; rs7794078; rs10266099; rs17170148; rs11760287; rs6954906; rs2016558; rs2056810; rs6946570; rs6962884; rs7804957; rs12155485; rs11772321; rs17169932; rs17170311; rs10270978; rs10487632; rs10241869; rs17170259; rs17170980; rs7791623; rs2107374; rs38047; rs2371642; rs2699468; rs4726717; rs17169952; rs10215691; rs12538024; rs13437693; rs6943693; rs10155999; rs1635362; rs11971183; rs12667944; rs38048; rs11983207; rs16882757; rs10238191; rs7785036; rs7805299; rs12703599; rs10215790; rs10281315; rs7795655; rs7804252; rs7811587; rs10225287; rs10257071; rs11762567; rs6974646; rs10269305; rs10253203; rs10248365; rs17170302; rs6942512; rs6971371; rs17170557; rs6979603; rs12703606; rs10225412; rs12112819; rs7788575; rs13224460; rs1612175; rs1635348; rs6957602; rs10235794; rs11763621; rs12703626; rs1024482; rs35199404; rs35296397; rs34413035; rs35979683; rs35323247; rs36198471; rs34028342; rs6953564; rs28380423; rs6974579; rs6968218; rs28413104; rs10233334; rs34081525; rs35608653; rs17170323; rs10270434; rs35884064; rs6955338; rs7791310; rs2371639; rs28571028; rs6974902; rs35339555; rs1635351; rs34944933; rs16882877; rs12669269; rs28694858; rs28579156; rs10238513; rs10629073; rs11464025; rs12672821; rs7809533; rs35756383; rs28479418; rs13309788; rs11422807; rs4577879; rs34930119; rs35674701; rs7457749; rs35566802; rs10269206; rs7785422; rs38046; rs34531513; rs34738180; rs11971469; rs6969108; rs28500750; rs34144974; rs35184499; rs6967551; rs7776547; rs35482667; rs13232304; rs11317716; rs1548575; rs36198319; rs35519609; rs10273497; rs13247723; rs2888112; rs2888077; rs12540744; rs10241824; rs7776761; rs1635342; rs34094997; rs10694465; rs6943850; rs10249761; rs35035774; rs10260046; rs3042327; rs7800284; rs13230714; rs40449; rs35779190; rs28678413; rs1635343; rs35855148; rs7798791; rs34599911; rs1635332; rs28588904; rs5888135; rs6978711; rs28570563; rs9690136; rs28398209; rs36200340; rs28460839; rs34378654; rs3040230; rs34900846; rs10239447; rs34277149; rs28707604; rs10231535; rs1635339; rs35756798; rs6966100; rs35405843; rs35845182; rs28569289; rs10280947; rs2371635; rs11452942; rs13310276; rs10262120; rs10452883; rs34186186; rs34832014; rs10256622; rs28811933; rs10270637; rs11305202; rs36000797; rs36199082; rs6957482; rs36111540; rs12672805; rs34794877; rs6971947; rs35207726; rs34163873; rs35303317; rs5888143; rs12535732; rs34377801; rs34681993; rs35315060; rs34159734; rs2371554; rs10274473; rs35037991; rs6976076; rs35996306; rs35014628; rs28837141; rs35800302; rs4726709; rs34760157; rs35369530; rs34346934; rs34911080; rs10281612; rs34204932; rs10250234; rs10256565; rs34094760; rs36200486; rs6951872; rs28536068; rs194199; rs12534453; rs34330120; rs6975960; rs1055453; rs11435034; rs35644156; rs35978701; rs28775953; rs6957471; rs34314577; rs34182425; rs28427458; rs13230159; rs28510201; rs34038262; rs10240789; rs6976587; rs17170470; rs28692603; rs2371636; rs13311747; rs3040234; rs11362341; rs36209911; rs6970520; rs35470246; rs34021822; rs13234053; rs35415710; rs35938048; rs10593775; rs6967950; rs1548574; rs10238737; rs13310390; rs2189737; rs35554801; rs34141808; rs34192766; rs34238625; rs34948287; rs10232358; rs6956274; rs2057866; rs13230156; rs10085603; rs12538029; rs12538712; rs34988092; rs17170892; rs4262256; rs6943976; rs469; rs10265951; rs6977297; rs5888137; rs10658437; rs36116998; rs13308436; rs28639532; rs11489444; rs34894024; rs10655130; rs35217619; rs36199514; rs35300949; rs28835313; rs11428871; rs6964024; rs39735; rs10249039; rs4333506; rs10243867; rs6955193; rs10244709; rs35976110; rs34008497; rs6975937; rs35198172; rs11459424; rs34389743; rs35859259; rs34628831; rs34859474; rs11980885; rs34687078; rs5888134; rs35271069; rs10232281; rs10268498; rs6942661; rs34097180; rs28850986; rs11426233; rs17286328; rs13311753; rs35778131; rs35560423; rs13311623; rs5888144; rs35792643; rs35118178; rs35768955; rs10271182; rs11771584; rs34480903; rs35493620; rs36200202; rs34670673; rs6958138; rs34927725; rs12666545; rs12668441; rs34835858; rs34757054; rs28373706; rs34545047; rs34209356; rs11323491; rs12333969; rs36199564; rs28457759; rs7793564; rs35341680; rs28706735; rs10567168; rs35157162; rs28739475; rs34520276; rs41363945; rs33976824; rs28757305; rs35132271; rs28522992; rs10632503; rs35033973; rs1731112; rs13311804; rs7811412; rs35041655; rs2888110; rs13222470; rs2107704; rs2371553; rs28734052; rs35751974; rs6963103; rs35206140; rs10244564; rs34930287; rs35978858; rs7778979; rs2888078; rs28558557; rs35331491; rs10589255; rs10281906; rs34588679; rs35286552; rs17170954; rs34106076; rs28795378; rs4295579; rs34027991; rs3044348; rs10543167; rs13222495; rs11426234; rs28409990; rs1548573; rs35804126; rs2888080; rs10546043; rs2057867; rs721493; rs28416581; rs34364330; rs1635340; rs10259099; rs34751464; rs35781071; rs6961469; rs6976586; rs10259003; rs6955704; rs35534367; rs28446438; rs10228841; rs13226290; rs10617992; rs34973340; rs35046308; rs3042361; rs7801990; rs34293334; rs13244027; rs34996473; rs13310266; rs7783226; rs39734; rs10557050; rs35719032; rs34585243; rs33910286; rs34241727; rs35877047; rs41390745; rs11458445; rs35809882; rs13224012; rs9691696; rs35312120; rs2107594; rs34096470; rs35400271; rs12333550; rs36073499; rs34128452; rs34252477; rs35175758; rs34032314; rs13438550; rs13226835; rs13311636; rs6944562; rs13309846; rs10567204; rs35209194; rs35690993; rs34161706; rs34153786; rs13242178; rs11308799; rs6966035; rs10232022; rs28786814; rs6951096; rs13244177; rs3042322; rs35103734; rs10558709; rs35086397; rs35849498; rs7777606; rs11765957; rs34987667; rs28442063; rs7798112; rs28522580; rs10238330; rs2215219; rs17169737; rs35563476; rs10228708; rs34979900; rs28449706; rs1635361; rs34800357; rs13310271; rs12703598; rs34993548; rs7457429; rs41414146; rs190431; rs13222795; rs34597425; rs6964422; rs35013318; rs6952616; rs7779535; rs35541550; rs28552544; rs28542660; rs35165109; rs34897822; rs35476062; rs28699201; rs5888141; rs34185081; rs35382979; rs181894; rs35945248; rs40368; rs35818347; rs35523161; rs10604976; rs35570697; rs28725366; rs13229070; rs13225873; rs6971096; rs11411012; rs2286114; rs4131050; rs13247895; rs35339919; rs35852163; rs6969529; rs10557051; rs6950852; rs13246358; rs6953773; rs35296036; rs13232152; rs34729838; rs6977355; rs17170517; rs38045; rs28459424; rs13309945; rs34369030; rs28460679; rs35737363; rs35634524; rs9692511; rs34393220; rs2214659; rs28488966; rs34768056; rs35482339; rs10268690; rs35207416; rs35284407; rs11376814; rs34973552; rs6960537; rs2888079; rs35394584; rs10260761; rs34441284; rs34593661; rs2371552; rs28812608; rs7802782; rs34839054; rs12531270; rs13235615; rs10253653; rs2888076; rs1852920; rs35508316; rs11317717; rs34305365; rs35290006; rs34287334; rs36123752; rs34262669; rs13311683; rs765812; rs4725654; rs1635341; rs3898399; rs2107373; rs28408177; rs34484688; rs34901202; rs35730928; rs13244051; rs10238761; rs34704697; rs35554770; rs5888136; rs28823046; rs35218248; rs13311749; rs34679766; rs10540369; rs28379884; rs34607788; rs34830524; rs34689761; rs13222135; rs7789947; rs35349541; rs34752041; rs185267; rs2888113; rs13311798; rs35959153; rs7797325; rs10602923; rs17170998; rs13226427; rs35633085; rs28817333; rs34841600; rs35314913; rs13238731; rs35167828; rs28623518; rs13238741; rs9785003; rs34917325; rs2371640; rs13310293; rs13243114; rs28577219; rs28537713; rs35025705; rs13222577; rs17170992; rs6953169; rs2371638; rs35155664; rs2371555; rs1635333; rs5888139; rs1635338; rs11274078; rs34015229; rs34216477; rs28651346; rs35356645; rs35342492; rs6975790; rs4141300; rs35628627; rs6976124; rs35154558; rs34787271; rs12703601; rs35896011; rs12670718; rs12531380; rs228576; rs13311613; rs28627969; rs13228305; rs11324716; rs34396105; rs28526582; rs40369; rs10244181; rs10251258; rs13311628; rs10675570; rs28576380; rs13310451; rs6952749; rs10568701; rs13246072; rs10614981; rs34638493; rs34617104; rs34594490; rs34055045; rs13235696; rs28465013; rs6943869; rs35368759; rs35104700; rs5888140; rs35054445; rs35656270; rs35455933; rs10666264; rs35148952; rs34902799; rs35410191; rs6947050; rs11976889; rs13309656; rs34151594; rs3042378; rs3042375; rs7790338; rs5888142; rs35159296; rs10248366; rs3757473; rs35903043; rs12666684; rs10239406; rs10239416; rs11765140; rs11978900; rs17173040; rs4725652; rs4726701; rs4726702; rs4726705; rs6957884; rs7780224

# Metabolic_Enzyme_90_General_References:
11342117

# Metabolic_Enzyme_90_References:
Not Available

# Metabolic_Enzyme_91_ID:
5906

# Metabolic_Enzyme_91_Name:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor

# Metabolic_Enzyme_91_Synonyms:
GMP-PDE beta

# Metabolic_Enzyme_91_Gene_Name:
PDE6B

# Metabolic_Enzyme_91_Protein_Sequence:
>Rod cGMPspecific 3',5'cyclic phosphodiesterase subunit beta precursor
MSLSEEQARSFLDQNPDFARQYFGKKLSPENVGRGCEDGCPPDCDSLRDLCQVEESTALL
ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE
DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI
MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL
WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY
SGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA
SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES
LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC
DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL
VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID
HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM
DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS
AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT
FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTEIC
NGGPAPKSSTCCIL

# Metabolic_Enzyme_91_Number_of_Residues:
854

# Metabolic_Enzyme_91_Molecular_Weight:
98408

# Metabolic_Enzyme_91_Theoretical_pI:
4.91

# Metabolic_Enzyme_91_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_91_General_Function:
Not Available

# Metabolic_Enzyme_91_Specific_Function:
This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme

# Metabolic_Enzyme_91_Pathway:
Not Available

# Metabolic_Enzyme_91_Reaction:
guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate

# Metabolic_Enzyme_91_Pfam_Domain_Function:
PF01590:GAF;
PF00233:PDEase_I

# Metabolic_Enzyme_91_Signals:
None

# Metabolic_Enzyme_91_Transmembrane_Regions:
None

# Metabolic_Enzyme_91_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_91_EC_Link:
EC 3.1.4.35

# Metabolic_Enzyme_91_GenBank_ID_Protein:
252253

# Metabolic_Enzyme_91_SwissProt_ID:
PDE6B_HUMAN (P35913)

# Metabolic_Enzyme_91_swissprot_Name:
Not Available

# Metabolic_Enzyme_91_Genecard_id:
PDE6B

# Metabolic_Enzyme_91_Geneatlas_id:
PDE6B

# Metabolic_Enzyme_91_hgnc_id:
HGNC:8786

# Metabolic_Enzyme_91_PDB_ID:
Not Available

# Metabolic_Enzyme_91_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_91_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_91_Subcellular_Location:
Membrane; lipid-anchor

# Metabolic_Enzyme_91_Gene_Sequence:
>2565 bp
ATGAGCCTCAGTGAGGAGCAGGCCCGGAGCTTTCTGGACCAGAACCCCGATTTTGCCCGC
CAGTACTTTGGGAAGAAACTGAGCCCTGAGAATGTTGGCCGCGGCTGCGAGGACGGGTGC
CCGCCGGACTGCGACAGCCTCCGGGACCTCTGCCAGGTGGAGGAGAGCACGGCGCTGCTG
GAGCTGGTGCAGGATATGCAGGAGAGCATCAACATGGAGCGCGTGGTCTTCAAGGTCCTG
CGGCGCCTCTGCACCCTCCTGCAGGCCGACCGCTGCAGCCTCTTCATGTACCGCCAGCGC
AACGGCGTGGCCGAGCTGGCCACCAGGCTTTTCAGCGTGCAGCCGGACAGCGTCCTGGAG
GACTGCCTGGTGCCCCCCGACTCCGAGATCGTCTTCCCACTGGACATCGGGGTCGTGGGC
CACGTGGCTCAGACCAAAAAGATGGTGAACGTCGAGGACGTGGCCGAGTGCCCTCACTTC
AGCTCATTTGCTGACGAGCTCACTGACTACAAGACAAAGAATATGCTGGCCACACCCATC
ATGAATGGCAAAGACGTCGTGGCGGTGATCATGGCAGTGAACAAGCTCAACGGCCCATTC
TTCACCAGCGAAGACGAAGATGTGTTCTTGAAGTACCTGAATTTTGCCACGTTGTACCTG
AAGATCTATCACCTGAGCTACCTCCACAACTGCGAGACGCGCCGCGGCCAGGTGCTGCTG
TGGTCGGCCAACAAGGTGTTTGAGGAGCTGACGGACATCGAGAGGCAGTTCCACAAGGCC
TTCTACACGGTGCGGGCCTACCTCAACTGCGAGCGGTACTCCGTGGGCCTCCTGGACATG
ACCAAGGAGAAGGAATTTTTTGACGTGTGGTCTGTGCTGATGGGAGAGTCCCAGCCGTAC
TCGGGCCCACGCACGCCTGATGGCCGGGAAATTGTCTTCTACAAAGTGATCGACTACATC
CTCCACGGCAAGGAGGAGATCAAGGTCATTCCCACACCCTCAGCCGATCACTGGGCCCTG
GCCAGCGGCCTTCCAAGCTACGTGGCAGAAAGCGGCTTTATTTGTAACATCATGAATGCT
TCCGCTGACGAAATGTTCAAATTTCAGGAAGGGGCCCTGGACGACTCCGGGTGGCTCATC
AAGAATGTGCTGTCCATGCCCATCGTCAACAAGAAGGAGGAGATTGTGGGAGTCGCCACA
TTTTACAACAGGAAAGACGGGAAGCCCTTTGACGAACAGGACGAGGTTCTCATGGAGTCC
CTGACACAGTTCCTGGGCTGGTCAGTGATGAACACCGACACCTACGACAAGATGAACAAG
CTGGAGAACCGCAAGGACATCGCACAGGACATGGTCCTTTACCACGTGAAGTGCGACAGG
GACGAGATCCAGCTCATCCTGCCAACCAGAGCGCGCCTGGGGAAGGAGCCTGCTGACTGC
GATGAGGACGAGCTGGGCGAAATCCTGAAGGAGGAGCTGCCAGGGCCCACCACATTTGAC
ATCTACGAATTCCACTTCTCTGACCTGGAGTGCACCGAACTGGACCTGGTCAAATGTGGC
ATCCAGATGTACTACGAGCTGGGCGTGGTCCGAAAGTTCCAGATCCCCCAGGAGGTCCTG
GTGCGGTTCCTGTTCTCCATCAGCAAAGGGTACCGGAGAATCACCTACCACAACTGGCGC
CACGGCTTCAACGTGGCCCAGACGATGTTCACGCTGCTCATGACCGGCAAACTGAAGAGC
TACTACACGGACCTGGAGGCCTTCGCCATGGTGACAGCCGGCCTGTGCCATGACATCGAC
CACCGCGGCACCAACAACCTGTACCAGATGAAGTCCCAGAACCCCTTGGCTAAGCTCCAC
GGCTCCTCGATTTTGGAGCGGCACCACCTGGAGTTTGGGAAGTTCCTGCTCTCGGAGGAG
ACCCTGAACATCTACCAGAACCTGAACCGGCGGCAGCACGAGCACGTGATCCACCTGATG
GACATCGCCATCATCGCCACGGACCTGGCCCTGTACTTCAAGAAGAGAGCGATGTTTCAG
AAGATCGTGGATGAGTCCAAGAACTACCAGGACAAGAAGAGCTGGGTGGAGTACCTGTCC
CTGGAGACGACCCGGAAGGAGATCGTCATGGCCATGATGATGACAGCCTGCGACCTGTCT
GCCATCACCAAGCCCTGGGAAGTCCAGAGCAAGGTCGCACTTCTCGTGGCTGCTGAGTTC
TGGGAGCAAGGTGACTTGGAAAGGACAGTCTTGGATCAGCAGCCCATTCCTATGATGGAC
CGGAACAAGGCGGCCGAGCTCCCCAAGCTGCAAGTGGGCTTCATCGACTTCGTGTGCACA
TTCGTGTACAAGGAGTTCTCTCGTTTCCACGAAGAGATCCTGCCCATGTTCGACCGACTG
CAGAACAATAGGAAAGAGTGGAAGGCGCTGGCTGATGAGTATGAGGCCAAAGTGAAGGCT
CTGGAGGAGAAGGAGGAGGAGGAGAGGGTGGCAGCCAAGAAAGTAGGCACAGAAATTTGC
AATGGCGGCCCAGCACCCAAGTCTTCAACCTGCTGTATCCTGTGA

# Metabolic_Enzyme_91_GenBank_ID_Gene:
S41458

# Metabolic_Enzyme_91_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_91_Locus:
4p16.3

# Metabolic_Enzyme_91_SNPs:
rs10029928; rs10007497; rs13101691; rs10030020; rs10023472; rs10029924; rs4075653; rs9994679; rs13133935; rs7438471; rs10031968; rs9997286; rs13116523; rs9998466; rs10033239; rs10017347; rs7669178; rs9999833; rs35925646; rs11734693; rs9991058; rs13127213; rs1135375; rs10031745; rs12501038; rs4426719; rs9995112; rs3895658; rs9996400; rs3888807; rs4690185; rs28568555; rs9992641; rs13139089; rs10027866; rs3891250; rs12331186; rs9998594; rs13117283; rs9998967; rs9996316; rs9998776; rs10027392; rs13107358; rs28414606; rs17849286; rs10902758; rs35792756; rs28510278; rs34380508; rs34749277; rs13106957; rs28675771; rs28710261; rs35513604; rs28862677; rs28538930; rs35535457; rs6858313; rs4292282; rs34281091; rs35498946; rs35714333; rs10010598; rs34698095; rs35621580; rs35691873; rs28711586; rs5021192; rs3934456; rs5855674; rs11945763; rs10050278; rs28588872; rs28569875; rs5021190; rs28583078; rs28483058; rs3929990; rs9985747; rs35214302; rs35436502; rs28438722; rs34845372; rs34165278; rs28573204; rs28459140; rs10028526; rs34477049; rs28600205; rs34953355; rs10018607; rs34587890; rs10014936; rs34149873; rs13133489; rs28520978; rs3929992; rs10028537; rs34992186; rs4690283; rs5021193; rs4505760; rs35207129; rs36117387; rs34568772; rs10027549; rs34524643; rs13143262; rs28374488; rs35935310; rs3929994; rs13143260; rs13103955; rs28476575; rs36060793; rs10024023; rs34096984; rs28742899; rs3934458; rs28754797; rs4690184; rs13143415; rs28502612; rs34328631; rs13140649; rs35564967; rs35134635; rs34549884; rs34177362; rs13119631; rs35732782; rs10011154; rs28615478; rs34101587; rs28438498; rs34391278; rs28478159; rs10001451; rs3934457; rs28469188; rs35448666; rs13114329; rs28380593; rs11932953; rs4690287; rs34415705; rs3934459; rs9990446; rs28742266; rs28399001; rs28485445; rs4549330; rs35694609; rs28407346; rs10017435; rs28818828; rs10023609; rs35649145; rs34902595; rs5021189; rs34612826; rs34585712; rs28605120; rs5021195; rs3864131; rs28706206; rs35669257; rs3864130; rs35400657; rs28514424; rs13114327; rs3929991; rs34363025; rs28413992; rs35584659; rs34366493; rs34907702; rs10002807; rs7436737; rs35137658; rs35978649; rs34721231; rs36093261; rs34421911; rs13109818; rs35972513; rs28483373; rs28630797; rs33997822; rs13104193; rs3929993; rs34756574; rs35958508; rs34358706; rs35847945; rs35894204; rs28687729; rs10035021; rs28436699; rs5021194; rs13119162; rs35853545; rs5021191; rs34801629; rs35556851; rs28586910; rs28504161; rs13140494; rs28488910; rs10007206; rs35869797; rs34290798; rs7699579; rs4446259; rs13115440; rs28477853; rs28535694; rs5021196; rs34094325; rs28665728; rs35199616; rs9998968; rs13107385; rs13128568; rs13147797; rs13128747; rs13104878; rs13145071; rs1802515; rs28525003; rs34268219; rs34307246; rs35091443; rs4463020; rs4690183; rs7665160

# Metabolic_Enzyme_91_General_References:
8394243; 1338685; 1322354; 1720239; 8768262; 8394174; 8075643; 7951329; 8595886; 8698075; 8557257; 8956055; 9543643

# Metabolic_Enzyme_91_References:
Not Available

# Metabolic_Enzyme_92_ID:
5908

# Metabolic_Enzyme_92_Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D

# Metabolic_Enzyme_92_Synonyms:
DPDE3; PDE43

# Metabolic_Enzyme_92_Gene_Name:
PDE4D

# Metabolic_Enzyme_92_Protein_Sequence:
>cAMPspecific 3',5'cyclic phosphodiesterase 4
DMEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPP
PPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCR
AMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQ
ANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNN
FAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHS
VSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKR
PMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRP
LTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLS
TPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVG
FKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGV
LLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPM
CDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPA
PDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIP
LDEQVEEEAVGEEEESQPEACVIDDRSPDT

# Metabolic_Enzyme_92_Number_of_Residues:
809

# Metabolic_Enzyme_92_Molecular_Weight:
91116

# Metabolic_Enzyme_92_Theoretical_pI:
5.25

# Metabolic_Enzyme_92_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_92_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_92_Specific_Function:
Regulates the levels of cAMP in the cell

# Metabolic_Enzyme_92_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_92_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_92_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_92_Signals:
None

# Metabolic_Enzyme_92_Transmembrane_Regions:
None

# Metabolic_Enzyme_92_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_92_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_92_GenBank_ID_Protein:
347130

# Metabolic_Enzyme_92_SwissProt_ID:
PDE4D_HUMAN (Q08499)

# Metabolic_Enzyme_92_swissprot_Name:
Not Available

# Metabolic_Enzyme_92_Genecard_id:
PDE4D

# Metabolic_Enzyme_92_Geneatlas_id:
PDE4D

# Metabolic_Enzyme_92_hgnc_id:
HGNC:8783

# Metabolic_Enzyme_92_PDB_ID:
Not Available

# Metabolic_Enzyme_92_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_92_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_92_Subcellular_Location:
Cytoplasm. Membrane (By similarity). Cytoplasm; cytoskeleton (By similarity). Centrosome (By similarity). Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity)

# Metabolic_Enzyme_92_Gene_Sequence:
>2024 bp
ACATGATGCACGTGAATAATTTTCCCTTTAGAAGGCATTCCTGGATATGTTTTGATGTGG
ACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGC
TAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCG
ACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATA
TACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTG
TACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCAC
CCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAAC
TGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGA
CCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGTTTAAAAGGATGCTTAATCGGGAGC
TCACCCATCTCTCTGAAATGAGTCGGTCTGGAAATCAAGTGTCAGAGTTTATATCAAACA
CATTCTTAGATAAGCAACATGAAGTGGAAATTCCTTCTCCAACTCAGAAGGAAAAGGAGA
AAAAGAAAAGACCAATGTCTCAGATCAGTGGAGTCAAGAAATTGATGCACAGCTCTAGTC
TGACTAATTCAAGTATCCCAAGGTTTGGAGTTAAAACTGAACAAGAAGATGTCCTTGCCA
AGGAACTAGAAGATGTGAACAAATGGGGTCTTCATGTTTTCAGAATAGCAGAGTTGTCTG
GTAACCGGCCCTTGACTGTTATCATGCACACCATTTTTCAGGAACGGGATTTATTAAAAA
CATTTAAAATTCCAGTAGATACTTTAATTACATATCTTATGACTCTCGAAGACCATTACC
ATGCTGATGTGGCCTATCACAACAATATCCATGCTGCAGATGTTGTCCAGTCTACTCATG
TGCTATTATCTACACCTGCTTTGGAGGCTGTGTTTACAGATTTGGAGATTCTTGCAGCAA
TTTTTGCCAGTGCAATACATGATGTAGATCATCCTGGTGTGTCCAATCAATTTCTGATCA
ATACAAACTCTGAACTTGCCTTGATGTACAATGATTCCTCAGTCTTAGAGAACCATCATT
TGGCTGTGGGCTTTAAATTGCTTCAGGAAGAAAACTGTGACATTTTCCAGAATTTGACCA
AAAAACAAAGACAATCTTTAAGGAAAATGGTCATTGACATCGTACTTGCAACAGATATGT
CAAAACACATGAATCTACTGGCTGATTTGAAGACTATGGTTGAAACTAAGAAAGTGACAA
GCTCTGGAGTTCTTCTTCTTGATAATTATTCCGATAGGATTCAGGTTCTTCAGAATATGG
TGCACTGTGCAGATCTGAGCAACCCAACAAAGCCTCTCCAGCTGTACCGCCAGTGGACGG
ACCGGATAATGGAGGAGTTCTTCCGCCAAGGAGACCGAGAGAGGGAACGTGGCATGGAGA
TAAGCCCCATGTGTGACAAGCACAATGCTTCCGTGGAAAAATCACAGGTGGGCTTCATAG
ACTATATTGTTCATCCCCTCTGGGAGACATGGGCAGACCTCGTCCACCCTGACGCCCAGG
ATATTTTGGACACTTTGGAGGACAATCGTGAATGGTACCAGAGCACAATCCCTCAGAGCC
CCTCTCCTGCACCTGATGACCCAGAGGAGGGCCGGCAGGGTCAAACTGAGAAATTCCAGT
TTGAACTAACTTTAGAGGAAGATGGTGAGTCAGACACGGAAAAGGACAGTGGCAGTCAAG
TGGAAGAAGACACTAGCTGCAGTGACTCCAAGACTCTTTGTACTCAAGACTCAGAGTCTA
CTGAAATTCCCCTTGATGAACAGGTTGAAGAGGAGGCAGTAGGGGAAGAAGAGGAAAGCC
AGCCTGAAGCCTGTGTCATAGATGATCGTTCTCCTGACACGTAA

# Metabolic_Enzyme_92_GenBank_ID_Gene:
L20970

# Metabolic_Enzyme_92_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_92_Locus:
5q12

# Metabolic_Enzyme_92_SNPs:
rs7736186; rs702530; rs702531; rs10075508; rs10036063; rs10940636; rs829259; rs10035437; rs829260; rs17719258; rs3839219; rs12658211; rs1471430; rs35285; rs1961; rs702543; rs1374028; rs1824159; rs1014317; rs1391651; rs244574; rs383444; rs2607347; rs244593; rs992726; rs27727; rs159195; rs2910642; rs40125; rs2409625; rs1498599; rs35286; rs1867724; rs702544; rs1348710; rs1395336; rs27957; rs171800; rs258125; rs35260; rs455969; rs1348709; rs35309; rs258110; rs27183; rs40126; rs27548; rs1498611; rs27549; rs441817; rs2702372; rs37569; rs1445918; rs716908; rs372309; rs149084; rs27949; rs27170; rs35255; rs1031197; rs40122; rs35310; rs1445948; rs294485; rs35265; rs26701; rs244577; rs28054; rs2968012; rs2968019; rs149106; rs167161; rs1345793; rs153968; rs986067; rs35281; rs40215; rs37353; rs294478; rs154222; rs35262; rs2936190; rs2014012; rs35282; rs1391649; rs2968009; rs35279; rs1078368; rs26712; rs1559251; rs2910641; rs1471429; rs1038080; rs889231; rs294482; rs35289; rs28044; rs922434; rs424839; rs187716; rs2591825; rs2547917; rs2968015; rs1391650; rs37575; rs377451; rs35277; rs988828; rs525099; rs2968011; rs929820; rs670169; rs1838733; rs921942; rs181736; rs1345792; rs2968003; rs154224; rs26708; rs27184; rs35274; rs35280; rs26711; rs988827; rs765182; rs159196; rs26705; rs154223; rs1579846; rs2409629; rs11958956; rs1023814; rs185333; rs26694; rs1423308; rs370891; rs9968728; rs258105; rs3805554; rs6892369; rs9292197; rs7724713; rs244590; rs2168649; rs4700316; rs1445952; rs2968014; rs35278; rs7707541; rs6861969; rs10043357; rs6450505; rs294494; rs2702373; rs2968006; rs258109; rs27172; rs1541672; rs255648; rs2409630; rs6886495; rs1498600; rs11744761; rs433565; rs6886854; rs244587; rs187645; rs6450496; rs27898; rs244566; rs7727206; rs1823068; rs10059053; rs26700; rs3763083; rs427433; rs6874460; rs10062176; rs1553114; rs1824788; rs2409627; rs27547; rs2194210; rs26695; rs889229; rs10056754; rs1870077; rs11951359; rs7703022; rs153980; rs1990985; rs7703658; rs10061553; rs27395; rs10062397; rs4618401; rs37576; rs255650; rs294496; rs35287; rs10067048; rs6450521; rs153966; rs7700365; rs159197; rs7717802; rs35267; rs1874859; rs258128; rs7724786; rs997421; rs27171; rs2910643; rs10038704; rs26709; rs171801; rs1824154; rs401013; rs165940; rs736736; rs10052657; rs464311; rs6886791; rs6450502; rs4700328; rs256752; rs7728050; rs37572; rs244575; rs6861992; rs6893655; rs154031; rs9292200; rs1551938; rs2013979; rs294500; rs1156029; rs4551023; rs2968005; rs1156028; rs35258; rs1445947; rs26710; rs6875727; rs7723432; rs11952840; rs12654005; rs294483; rs6879949; rs172362; rs721826; rs6877743; rs10461656; rs26687; rs153978; rs7713369; rs244570; rs1947090; rs1817248; rs7712329; rs291122; rs6874089; rs6869400; rs1077183; rs7719441; rs4700317; rs1506557; rs7730070; rs10805513; rs10940644; rs6895685; rs2607343; rs10071163; rs1867711; rs27168; rs151802; rs154024; rs153982; rs12697177; rs35275; rs6450515; rs9292202; rs6450518; rs154028; rs6450512; rs255633; rs12697173; rs10041021; rs258107; rs37574; rs1350298; rs11746896; rs153985; rs1353748; rs9292195; rs1848060; rs10037973; rs258121; rs10062340; rs371775; rs10075104; rs291118; rs2968004; rs4700325; rs12697171; rs7443333; rs154025; rs2028842; rs13176291; rs378858; rs244573; rs2409631; rs6450498; rs153961; rs6883834; rs10064744; rs6887017; rs1457145; rs255649; rs7728286; rs2098699; rs1551564; rs10035950; rs2028836; rs40328; rs1553113; rs6897568; rs7735228; rs6877508; rs1862563; rs1445954; rs7735376; rs153979; rs149108; rs26688; rs1551939; rs4699932; rs244592; rs40444; rs1498601; rs1395337; rs27773; rs7734053; rs6450514; rs3852147; rs6450519; rs6867240; rs6450516; rs13356883; rs258111; rs4700315; rs6881054; rs1876209; rs244594; rs1457110; rs11957770; rs26714; rs7734070; rs244595; rs26715; rs6885378; rs6867053; rs12652499; rs378970; rs294484; rs244596; rs11958928; rs3805553; rs9292198; rs6877927; rs10066573; rs9283720; rs368538; rs181915; rs1345791; rs10223103; rs294492; rs392901; rs26689; rs1971061; rs1391648; rs244591; rs255647; rs12055306; rs1353749; rs7712076; rs6898374; rs7735572; rs1546221; rs1971940; rs10037958; rs37571; rs1445953; rs1035321; rs2702363; rs2112957; rs10940638; rs153981; rs6893668; rs10055769; rs464787; rs6870632; rs26702; rs10055954; rs2968018; rs35307; rs13328162; rs4699935; rs16889904; rs6450510; rs258112; rs35263; rs10040847; rs255557; rs256750; rs6450517; rs294497; rs17720639; rs16888990; rs10514861; rs16889611; rs13185828; rs1498608; rs11743194; rs27179; rs6450506; rs12518641; rs12655617; rs244571; rs3891334; rs10461657; rs11959801; rs16889427; rs974766; rs39672; rs7735570; rs7724814; rs10514864; rs1120303; rs4699941; rs10068543; rs11954668; rs16889885; rs6892860; rs153949; rs2607340; rs2936193; rs7729339; rs2591750; rs6896121; rs2591744; rs17797781; rs381755; rs13362239; rs10045879; rs10472081; rs10058478; rs1363882; rs9292205; rs7733296; rs10051287; rs10472105; rs11747104; rs13358738; rs10070436; rs2055297; rs17589766; rs9292186; rs295936; rs7701455; rs11740402; rs35259; rs6450522; rs428059; rs2547918; rs6869149; rs10065303; rs17528473; rs13155290; rs9292182; rs1874857; rs6891130; rs12186707; rs1838721; rs27175; rs10072367; rs6889851; rs7707392; rs6859139; rs27185; rs27695; rs2591749; rs13185063; rs17795692; rs28055; rs16889920; rs244581; rs17444185; rs244579; rs7712725; rs16889849; rs1909294; rs12514190; rs2081106; rs11738043; rs11952875; rs2081093; rs35305; rs2036220; rs13176475; rs7716276; rs16889805; rs154027; rs27181; rs35283; rs17589633; rs1813481; rs27187; rs10064893; rs433161; rs12109774; rs16889518; rs1541673; rs10471467; rs7717819; rs1960; rs4700314; rs7714707; rs10039312; rs187644; rs2034894; rs1823070; rs258106; rs255579; rs13160617; rs6450501; rs35284; rs13176940; rs2059191; rs11739293; rs13180599; rs6864156; rs255655; rs10472093; rs244582; rs1848059; rs27182; rs10069146; rs10065334; rs12697170; rs13354437; rs1975533; rs6888644; rs174039; rs11952011; rs17796734; rs35261; rs9292189; rs6867591; rs10041537; rs2216699; rs16889682; rs17528543; rs931855; rs37573; rs16888998; rs6450513; rs2547920; rs3816996; rs27174; rs6888474; rs10068836; rs12187079; rs10472106; rs16889508; rs1439; rs2055298; rs2702365; rs7714708; rs17528285; rs669240; rs17726292; rs258127; rs6450497; rs7703702; rs10085076; rs17721878; rs414746; rs16889796; rs17727615; rs4700321; rs2591748; rs10514871; rs11747413; rs2112910; rs11957827; rs10055095; rs4699939; rs6861842; rs10045878; rs11744488; rs209983; rs11951879; rs16889853; rs1115728; rs4321723; rs7717303; rs7719347; rs13355884; rs10075067; rs378869; rs16889280; rs16889907; rs244583; rs7723695; rs37579; rs9292185; rs12654485; rs27641; rs9292199; rs2591651; rs255652; rs10514863; rs10074854; rs17780175; rs2591826; rs13355401; rs10058672; rs2021384; rs1579848; rs2112956; rs294479; rs12517657; rs17444059; rs10471463; rs7733716; rs7730574; rs10471466; rs291119; rs487029; rs12656462; rs16889906; rs294491; rs10070294; rs10514860; rs6876934; rs651576; rs10038599; rs7737685; rs6871710; rs6862702; rs12657171; rs294481; rs12187448; rs12658554; rs2034893; rs13161623; rs7703452; rs573336; rs10472102; rs467300; rs16889874; rs11948651; rs6897015; rs16889512; rs7711639; rs11748392; rs6858946; rs16889175; rs6890598; rs697076; rs17778950; rs10058681; rs10461659; rs7707065; rs1542842; rs7701945; rs6896497; rs1605275; rs172363; rs11959132; rs10063540; rs6865647; rs1823066; rs13180690; rs10051847; rs42470; rs1105577; rs6891161; rs4700322; rs434422; rs10491352; rs9292188; rs27188; rs13361218; rs11957151; rs16889495; rs387647; rs6895550; rs193447; rs1498606; rs12518773; rs244568; rs294498; rs10491353; rs12658429; rs7730750; rs10514866; rs17782374; rs17776879; rs2441091; rs10073507; rs10055884; rs10065699; rs826435; rs16889883; rs10056637; rs10051191; rs6450509; rs12522563; rs153948; rs294476; rs12519611; rs16889129; rs17777413; rs16889248; rs6875867; rs17782969; rs27176; rs10071881; rs17796040; rs1395335; rs10514865; rs427748; rs7717821; rs16889810; rs11750426; rs7706227; rs427740; rs10514870; rs12514658; rs10058823; rs444552; rs10059709; rs17776825; rs1078369; rs1874858; rs244588; rs1445950; rs10044687; rs16889869; rs17780213; rs17780860; rs16889126; rs9292194; rs10056492; rs2968010; rs294474; rs950446; rs16889615; rs10043404; rs10038299; rs6450504; rs545611; rs2055296; rs10472082; rs6875027; rs4631140; rs17783275; rs26703; rs10440630; rs27178; rs10074426; rs10514862; rs10940642; rs9292206; rs1867725; rs13357758; rs9292184; rs17782238; rs35306; rs11948070; rs6892879; rs3805557; rs10036406; rs6858964; rs2968013; rs12653844; rs244580; rs6898269; rs6889456; rs10068809; rs6872134; rs6862564; rs11949561; rs10038855; rs17528634; rs17727092; rs7700870; rs2081092; rs13153653; rs6898082; rs2702369; rs12186633; rs3805556; rs16889412; rs3763084; rs425384; rs27670; rs13362115; rs2702371; rs35276; rs11960438; rs154221; rs255635; rs186078; rs7736808; rs10805515; rs27180; rs10058676; rs40216; rs918583; rs10079396; rs13160457; rs10036199; rs1457146; rs3901540; rs16889921; rs16889276; rs10077993; rs17443709; rs255654; rs7717248; rs11948356; rs1559252; rs6888028; rs10471465; rs17797996; rs16889876; rs6866342; rs6872808; rs17740767; rs454702; rs13162275; rs7735375; rs953302; rs10069009; rs389324; rs9918228; rs1457111; rs11738454; rs10077018; rs26704; rs244565; rs13173038; rs7715956; rs11949324; rs6871806; rs17723785; rs4479801; rs2059175; rs4699930; rs13355507; rs6896337; rs7707043; rs13189127; rs3903515; rs6894694; rs9918111; rs16889882; rs2547921; rs12656663; rs7728221; rs11956680; rs171729; rs10052856; rs6859693; rs6871410; rs10155628; rs17795596; rs10070295; rs1840838; rs16889912; rs153965; rs6884572; rs294503; rs10042425; rs16877155; rs13354210; rs17796824; rs6869578; rs6893986; rs11952435; rs13186012; rs17528453; rs6875497; rs17721311; rs697075; rs10073292; rs16889254; rs443191; rs11950805; rs1579845; rs10461660; rs11952527; rs1115729; rs13167220; rs16889908; rs294486; rs258123; rs6896519; rs7733300; rs9292193; rs244576; rs17741863; rs364528; rs7714403; rs10035390; rs11951025; rs17780740; rs13328175; rs682796; rs13362242; rs16889892; rs10940645; rs6876057; rs17719378; rs10472089; rs11955850; rs294499; rs9647533; rs10042606; rs931856; rs2968002; rs9918215; rs13189942; rs16889307; rs10514859; rs17528578; rs17777280; rs17721133; rs17722929; rs1644948; rs10043994; rs10061786; rs27532; rs2702375; rs12656132; rs2936201; rs13188077; rs13176997; rs10072637; rs6877740; rs7708183; rs1579849; rs2409628; rs2968001; rs16889901; rs1353747; rs34738; rs11749543; rs11954898; rs10077198; rs9687424; rs9292196; rs17528550; rs9292190; rs7729722; rs17725522; rs3805555; rs6877256; rs10056526; rs12521370; rs10472084; rs10055446; rs13177192; rs17720871; rs17721860; rs2409646; rs7726987; rs256120; rs6894618; rs7732124; rs11742439; rs958851; rs255651; rs6871017; rs10044336; rs12658004; rs922437; rs6892534; rs9292201; rs10039006; rs10058483; rs7707566; rs13357723; rs10042726; rs10472101; rs2409614; rs16889948; rs10062858; rs13187670; rs11747358; rs2061282; rs13360359; rs7716261; rs11956820; rs244586; rs17780584; rs16877169; rs17779217; rs1846369; rs10059809; rs291117; rs10042103; rs490105; rs6879216; rs13178514; rs258108; rs13360195; rs33927508; rs6870929; rs13154145; rs13361668; rs35308; rs7444432; rs950447; rs159194; rs13328174; rs16889167; rs2112959; rs13361223; rs1077978; rs6882204; rs13188962; rs4629551; rs2702361; rs10940640; rs10069187; rs17628114; rs11739354; rs10039990; rs6875884; rs17777617; rs2936199; rs7729776; rs17740749; rs10061320; rs1498609; rs1463816; rs10214048; rs13154828; rs2021776; rs1823067; rs380993; rs9918225; rs9292192; rs12522220; rs16889606; rs13165581; rs2968021; rs16889521; rs35288; rs244569; rs190433; rs1973450; rs4700335; rs16889919; rs10472107; rs12187317; rs16889274; rs153983; rs294477; rs403695; rs4699931; rs10155599; rs16889903; rs10051456; rs11955452; rs10070138; rs258120; rs1947095; rs6872107; rs16889913; rs10062986; rs34739; rs5010782; rs244585; rs387997; rs1108916; rs1909295; rs26713; rs10035257; rs6868963; rs10037978; rs419953; rs2161513; rs10035719; rs2936202; rs17528257; rs10040394; rs391377; rs2607349; rs149506; rs573230; rs7710479; rs244597; rs10055869; rs7704805; rs2702377; rs294495; rs13355229; rs16889484; rs11950544; rs35266; rs16889865; rs466978; rs11738525; rs1974839; rs17528522; rs6450520; rs403687; rs10063703; rs6890168; rs4700318; rs1532520; rs7701758; rs10068715; rs12521279; rs36064814; rs7713345; rs7719732; rs6874473; rs4326095; rs13183985; rs16889392; rs13328160; rs10155544; rs10940641; rs10052063; rs10065078; rs6870927; rs4395595; rs1463817; rs10045258; rs168641; rs17796399; rs6883494; rs153967; rs17776777; rs12186492; rs434274; rs10042733; rs10452450; rs16889499; rs1902609; rs10065206; rs371398; rs2591751; rs11959567; rs10471470; rs7729912; rs10044298; rs28385324; rs3087748; rs16889925; rs17740844; rs11955845; rs17797601; rs12188859; rs13169097; rs12697174; rs2591747; rs10054429; rs10079544; rs34235034; rs380118; rs6895303; rs6891589; rs13190249; rs8180396; rs10064468; rs10079614; rs11957508; rs1379297; rs4699937; rs6883346; rs10051023; rs6897538; rs12108729; rs13358203; rs16877156; rs12188029; rs16889878; rs258122; rs13328226; rs7716975; rs931857; rs11747768; rs16889896; rs10059338; rs2021775; rs13164981; rs17724250; rs2059174; rs258104; rs11746579; rs27173; rs7711904; rs244584; rs16889696; rs6875906; rs403672; rs16889190; rs10043671; rs10036287; rs294501; rs17798241; rs10065540; rs17798319; rs10040395; rs17741233; rs9292181; rs17589745; rs9686835; rs255812; rs6876050; rs13173495; rs10039572; rs10067196; rs10472098; rs10038321; rs16889743; rs16889161; rs17721564; rs10042327; rs16889846; rs2702360; rs10155627; rs13354657; rs16889478; rs6881137; rs10075364; rs10214073; rs13161585; rs10061206; rs4395596; rs382411; rs2216687; rs16889733; rs17781354; rs6863716; rs10057278; rs374713; rs1160958; rs16889227; rs9918223; rs419744; rs4700329; rs291120; rs258129; rs40203; rs10065498; rs9687262; rs9716722; rs17728654; rs7736385; rs1598740; rs8180419; rs10035212; rs6897504; rs1902610; rs6874662; rs6892252; rs10075171; rs13174180; rs11746624; rs27189; rs9292187; rs154023; rs13362296; rs10077672; rs12656944; rs13178315; rs10060200; rs16889258; rs3815764; rs10078763; rs6891288; rs153969; rs2277014; rs11739601; rs17725949; rs35264; rs16889181; rs16889479; rs4469166; rs4618402; rs154026; rs168834; rs10053330; rs2291851; rs2936200; rs17720311; rs7735133; rs6450508; rs1498612; rs10078754; rs11744259; rs7706044; rs466376; rs2409626; rs7702291; rs27723; rs17780836; rs4699938; rs12655844; rs11950492; rs13160982; rs10071088; rs11959349; rs10472110; rs11956001; rs829258; rs17291089; rs11950495; rs1058458; rs17853590; rs17853589; rs1058459; rs35684984; rs35839600; rs12187668; rs34530754; rs35859095; rs34835493; rs3839217; rs3839218; rs10718401; rs35914743; rs34128632; rs34115255; rs922435; rs34848147; rs35818307; rs27186; rs10574102; rs1209433; rs13169163; rs11365445; rs28505532; rs2034895; rs28725359; rs6149040; rs35851251; rs649476; rs34677469; rs35617728; rs13162482; rs35860266; rs11365791; rs35776313; rs258117; rs11413392; rs1143233; rs33950471; rs34854664; rs34187013; rs35879110; rs211670; rs35244458; rs2409613; rs7727032; rs33976406; rs1871181; rs34207840; rs294480; rs35785066; rs10660174; rs35366471; rs10079826; rs10586960; rs28461689; rs16889366; rs34060514; rs33991327; rs11418242; rs34996240; rs11436951; rs35078554; rs2936197; rs34455241; rs11401918; rs7700296; rs10056649; rs34563226; rs1813483; rs10603279; rs36048558; rs2591743; rs35264771; rs11429076; rs2702362; rs34153401; rs34555936; rs447261; rs1867712; rs10045441; rs10656770; rs159393; rs34567562; rs374691; rs12517094; rs11305111; rs5868184; rs10682149; rs35798154; rs3061653; rs13165285; rs36227655; rs6882478; rs7716631; rs6880249; rs12659081; rs34058811; rs34126067; rs12521516; rs34154445; rs6886569; rs7734463; rs1202161; rs13171241; rs35731466; rs34984294; rs2409648; rs2936189; rs34935059; rs4558950; rs13170796; rs11383327; rs7737978; rs34726071; rs1075641; rs35098298; rs7723289; rs13184217; rs35011298; rs6864694; rs4513648; rs10536982; rs11444928; rs34296140; rs36019972; rs35561012; rs35182475; rs2936203; rs5868170; rs10693866; rs5868155; rs34492945; rs1974836; rs36226812; rs3061616; rs13176721; rs34863757; rs1498610; rs10056619; rs11448342; rs1143230; rs33969423; rs34222623; rs35643183; rs34682234; rs35037415; rs36121613; rs34924381; rs190486; rs5868182; rs35842486; rs35507986; rs13156498; rs35924466; rs35092276; rs2936191; rs3989138; rs10472097; rs11447857; rs13177495; rs34301317; rs34696511; rs10581563; rs295934; rs10563874; rs5868157; rs2001663; rs34033893; rs34118182; rs34733788; rs34838287; rs34660223; rs28568571; rs28688372; rs35238877; rs7701039; rs3061422; rs13165299; rs34596458; rs35985169; rs3060393; rs34138345; rs34991840; rs34493562; rs13358946; rs4604141; rs35802681; rs28427182; rs35854938; rs34714025; rs1840846; rs10626836; rs17444108; rs3061651; rs2409645; rs34310135; rs13359304; rs10587602; rs244567; rs34120574; rs7700594; rs458953; rs7731885; rs13179931; rs2702364; rs3061709; rs35613781; rs34091391; rs33952315; rs34508989; rs35205837; rs1038079; rs35260023; rs34651837; rs11746156; rs5868167; rs34523714; rs34074485; rs977465; rs35035421; rs33915770; rs34756714; rs13357070; rs34505227; rs7731299; rs34047116; rs7445308; rs28403116; rs35338151; rs34172825; rs34418802; rs35926698; rs10672523; rs13154098; rs35376564; rs166261; rs34339765; rs2591752; rs13178411; rs1973451; rs28696115; rs17528223; rs34612377; rs35425879; rs6898554; rs34234985; rs10053177; rs35406293; rs2291852; rs7723589; rs35238842; rs34018147; rs1974840; rs34088870; rs28595613; rs255459; rs13159623; rs722010; rs35119819; rs1143231; rs185320; rs4426880; rs13359998; rs13171236; rs4619980; rs28713675; rs35883616; rs5868186; rs381332; rs28372523; rs36228173; rs13189436; rs34571539; rs34740; rs35047246; rs11461880; rs35450213; rs35253855; rs34686327; rs35126822; rs34685247; rs17443688; rs34086576; rs10472091; rs13190508; rs2547919; rs7738023; rs13157164; rs34990310; rs34269653; rs11371708; rs5868177; rs36172625; rs3061656; rs34308828; rs35455534; rs2607345; rs13159548; rs187368; rs13157341; rs4700323; rs1824157; rs1075640; rs35021239; rs1031198; rs3061658; rs35903843; rs13156940; rs11338647; rs13187400; rs2054443; rs3061710; rs34235697; rs3061308; rs35151567; rs440664; rs34472588; rs36088481; rs1813482; rs7711649; rs34084892; rs13360916; rs10572313; rs11349021; rs34207293; rs5868174; rs28424104; rs7715430; rs33940460; rs294502; rs13354612; rs7713258; rs5868152; rs36027270; rs3060391; rs10562385; rs28647633; rs35687752; rs7735196; rs35969214; rs10078108; rs36003579; rs33946616; rs7712922; rs2898243; rs432879; rs13362039; rs28620612; rs35979851; rs27691; rs35491995; rs10058612; rs13178256; rs10617961; rs35622981; rs35490549; rs11412067; rs35651411; rs185417; rs35939103; rs6884220; rs35476254; rs35234690; rs34662839; rs41405750; rs7713801; rs35584387; rs27169; rs35127834; rs34298707; rs11954741; rs34598563; rs35656102; rs34575207; rs34551750; rs13170793; rs35855221; rs35895437; rs3061409; rs34422101; rs13361043; rs34751449; rs35598166; rs35676156; rs2135480; rs36089178; rs4699936; rs28876414; rs35500271; rs34200989; rs13356176; rs3061708; rs10551360; rs6883912; rs28885736; rs6874847; rs1909296; rs35499758; rs7705352; rs35501358; rs2028841; rs35189950; rs28531774; rs13162317; rs173887; rs35943594; rs35339520; rs13184036; rs2968020; rs34379829; rs34769858; rs722923; rs7735649; rs34233597; rs28369243; rs35329504; rs13186000; rs2607341; rs6873109; rs258116; rs34624326; rs35259546; rs36072354; rs2607348; rs3061467; rs34344560; rs35448373; rs10035396; rs9716593; rs34680701; rs34453807; rs34593368; rs13179144; rs13328098; rs28648858; rs35735511; rs11373971; rs6871100; rs10063724; rs11955117; rs17797035; rs35227733; rs35304; rs7731607; rs17777238; rs36153134; rs34209888; rs33911877; rs13180196; rs258119; rs7713808; rs34533703; rs3061702; rs10040742; rs34501738; rs13158325; rs255656; rs431645; rs13159276; rs11351473; rs190432; rs10062189; rs35516422; rs35073004; rs34862762; rs34468745; rs35509503; rs34768031; rs35587177; rs33941389; rs6869945; rs35243888; rs2968016; rs10633205; rs2055295; rs1143236; rs35453725; rs11348414; rs3061706; rs6450503; rs3061457; rs35943112; rs13347326; rs35868304; rs35959609; rs35147554; rs6895251; rs33922784; rs35913935; rs28705844; rs7705784; rs34217990; rs10581664; rs7444132; rs2174624; rs5868163; rs1838720; rs10052704; rs10573988; rs35692333; rs34507601; rs11280004; rs34873380; rs255460; rs4441841; rs35943702; rs35966656; rs28571683; rs35925966; rs28735903; rs13163857; rs13177851; rs7710901; rs13178378; rs34209564; rs35365611; rs6149041; rs26686; rs34351758; rs35671080; rs6880654; rs154029; rs7710055; rs35190866; rs33949395; rs28490233; rs7735819; rs2607346; rs34621496; rs10070588; rs35836561; rs13187778; rs35343334; rs10471469; rs35526059; rs34709522; rs5868179; rs34649343; rs35231519; rs34555200; rs10699804; rs10041815; rs12188999; rs7737269; rs35954639; rs13181587; rs34314412; rs1506562; rs28508065; rs34879089; rs7737071; rs154220; rs10704376; rs6879049; rs13178988; rs35597897; rs7731419; rs9942415; rs6870989; rs34249657; rs10472095; rs5868168; rs11737993; rs34949154; rs28406753; rs35020719; rs1498607; rs3061415; rs34785566; rs745813; rs34276144; rs5868172; rs7717793; rs34592041; rs36157268; rs6877826; rs34084254; rs35818881; rs34669732; rs35063826; rs1472456; rs35069329; rs34248179; rs35027879; rs5868150; rs35837060; rs13154094; rs10472092; rs28529077; rs1350297; rs11420361; rs6875864; rs35399502; rs34554235; rs34907429; rs36034409; rs4700326; rs11948460; rs35459588; rs35553072; rs35979928; rs36074437; rs11325874; rs11953985; rs34017676; rs28415294; rs36098200; rs166260; rs35505239; rs16888929; rs9292191; rs10044159; rs10052007; rs10658576; rs34876197; rs176705; rs10041861; rs13358675; rs34131200; rs10472096; rs35653778; rs10641798; rs5868173; rs34683467; rs5868154; rs34275268; rs3061615; rs5868181; rs294475; rs34549454; rs35720109; rs35500652; rs34532597; rs34815381; rs166249; rs956180; rs10551181; rs10549903; rs34591489; rs10664902; rs531511; rs153984; rs153647; rs28430615; rs35326955; rs10079932; rs28544243; rs35500676; rs2112911; rs2936192; rs36121052; rs34681204; rs3061414; rs34943144; rs35494444; rs13175289; rs34715930; rs1143229; rs2702370; rs28429524; rs34211584; rs34992012; rs702545; rs11425003; rs34025440; rs34636836; rs4099231; rs35728243; rs7721436; rs13190507; rs34671126; rs34688238; rs34422882; rs12518035; rs531105; rs34206938; rs5868161; rs13181967; rs35194865; rs10085037; rs33953218; rs7709897; rs35838554; rs10434567; rs34521304; rs35496140; rs13177540; rs365223; rs35050580; rs10624686; rs12187491; rs36125698; rs36086955; rs7710053; rs258118; rs10471464; rs10626837; rs12108992; rs4700324; rs34457252; rs34449506; rs34490359; rs3061711; rs10085136; rs1143232; rs28657905; rs10595185; rs34098961; rs34550093; rs33951927; rs33964029; rs4699940; rs7711648; rs35355640; rs11744760; rs12110099; rs2409640; rs33945017; rs7707469; rs33923129; rs35342625; rs255634; rs7725632; rs13164719; rs34249117; rs35218911; rs922436; rs34795725; rs12514095; rs34539185; rs35356120; rs35388375; rs2044419; rs27722; rs1065494; rs528422; rs35473646; rs10587603; rs34797165; rs12522944; rs7443305; rs10641593; rs34734362; rs10717217; rs530656; rs34648106; rs35578341; rs1391652; rs11412476; rs10039838; rs10661060; rs13159605; rs1186170; rs10701223; rs35561822; rs13161215; rs7707404; rs10058671; rs10561334; rs34665636; rs4621516; rs7705360; rs12656432; rs34331472; rs35150172; rs5008690; rs34569783; rs35898879; rs2277013; rs383046; rs35182359; rs10223254; rs11324683; rs13179935; rs34433570; rs34156880; rs5868185; rs36203538; rs7443891; rs10533055; rs13359805; rs295933; rs34818966; rs5868171; rs11740671; rs10472090; rs11412487; rs33920644; rs2306292; rs1974841; rs28505210; rs34029569; rs6894319; rs12521263; rs11738599; rs34389985; rs13360907; rs6860418; rs35697600; rs13161103; rs2607344; rs5868176; rs7713069; rs34116835; rs10061600; rs34917776; rs36029168; rs28430839; rs34730535; rs10044993; rs10554068; rs682823; rs6891238; rs35187858; rs11366994; rs7712717; rs27177; rs10565535; rs16889147; rs12656961; rs28706428; rs7715622; rs611540; rs186079; rs13173458; rs34049029; rs13154123; rs35987304; rs35410510; rs11457080; rs1445951; rs37570; rs36131717; rs11955408; rs34206672; rs924998; rs5868164; rs11745169; rs34793823; rs35543326; rs35971368; rs11354852; rs17628143; rs35338164; rs33989667; rs10472087; rs34415724; rs7714489; rs434183; rs34085161; rs35163676; rs5868156; rs10707669; rs16889662; rs34615918; rs5868153; rs10056025; rs34029709; rs34252655; rs5868183; rs5868159; rs6892851; rs6896215; rs9717124; rs255653; rs35606632; rs28555377; rs28680208; rs1506558; rs11748888; rs34497390; rs11356537; rs6872782; rs34203891; rs6867393; rs1960757; rs34680150; rs7725779; rs28460862; rs34071921; rs35039897; rs6871694; rs34280879; rs36062192; rs34141079; rs1816081; rs35900836; rs35005183; rs13178213; rs34372825; rs34584672; rs34161581; rs34283365; rs7709565; rs34130701; rs2936196; rs34261138; rs9716000; rs258124; rs11447636; rs4379155; rs35516815; rs13162130; rs1870078; rs10461658; rs35251595; rs34842927; rs6890180; rs13158460; rs34183853; rs34298212; rs10076635; rs41447947; rs34297420; rs35948623; rs34729847; rs35112587; rs255458; rs12153416; rs35519507; rs36068157; rs11746769; rs4700320; rs2067346; rs12152794; rs10639186; rs33913249; rs13358027; rs10555061; rs10579840; rs1133158; rs35082015; rs34052142; rs34646492; rs34322052; rs34424874; rs35684548; rs11952286; rs35106150; rs1870076; rs7736448; rs36158560; rs34985394; rs5868169; rs35746970; rs5868166; rs10600245; rs35116914; rs10472100; rs256128; rs34054950; rs1457112; rs28513138; rs28562290; rs35131890; rs258114; rs258113; rs13185873; rs33937382; rs34060150; rs34916796; rs2702374; rs34357376; rs3061418; rs11952118; rs2607342; rs33993022; rs7715325; rs36030058; rs11387250; rs2548039; rs462930; rs35501009; rs34877183; rs10616440; rs35413991; rs35142413; rs35633619; rs36124270; rs10074406; rs34564012; rs34873866; rs13155404; rs34086583; rs34107557; rs34665834; rs34337000; rs10653014; rs10054481; rs34398584; rs34537847; rs34575928; rs10035258; rs10058539; rs10042414; rs34642374; rs28604386; rs6888386; rs13154271; rs6883563; rs12656245; rs5868175; rs6885690; rs12517745; rs13154277; rs35705115; rs35604134; rs10652340; rs28398197; rs466742; rs34265208; rs36014965; rs35585210; rs13186140; rs7341134; rs6450507; rs721784; rs258126; rs2591745; rs13161395; rs10648089; rs2702376; rs40121; rs28540859; rs35963925; rs12187338; rs35952598; rs611541; rs35797347; rs11738575; rs11350151; rs34092633; rs13358942; rs6149042; rs35450986; rs11346574; rs12516263; rs34285029; rs10698730; rs4627950; rs6898408; rs13185996; rs149107; rs7704141; rs34918657; rs11958824; rs7737908; rs10626977; rs35689772; rs34983709; rs35917605; rs1974838; rs10672522; rs10560642; rs11421072; rs3061408; rs35036216; rs35943533; rs12187142; rs10472088; rs11349022; rs11277625; rs34876134; rs10600503; rs7733370; rs35302311; rs10686252; rs34315041; rs36011948; rs185325; rs35273659; rs10556090; rs28660597; rs34506272; rs34254880; rs34072469; rs575045; rs35859105; rs7444519; rs12109436; rs12189022; rs34982318; rs954740; rs34256357; rs13179611; rs11949985; rs11953154; rs35801943; rs34306611; rs28862729; rs1664886; rs35950250; rs34024693; rs7733884; rs11952378; rs13359707; rs11413820; rs36080031; rs5868178; rs11951378; rs13181969; rs33910828; rs34629419; rs5868160; rs441683; rs7715975; rs34908081; rs28694209; rs3061472; rs7356672; rs34856947; rs4551022; rs34711969; rs6888059; rs35274311; rs34353158; rs36019773; rs35964845; rs28539646; rs10472094; rs1138029; rs28666954; rs13357540; rs13158346; rs4279300; rs3060388; rs7445460; rs10562252; rs13167988; rs13186015; rs34031021; rs1065495; rs35457740; rs3061466; rs7728853; rs258115; rs429191; rs13161214; rs7710342; rs36051277; rs10710659; rs5868151; rs1579316; rs6898386; rs34023059; rs10701279; rs10045150; rs34631941; rs11347219; rs9942390; rs35890577; rs34153724; rs28435484; rs6887956; rs34405862; rs35225834; rs11414841; rs34553923; rs34424978; rs1202160; rs10940639; rs10039319; rs6877904; rs36094087; rs7716117; rs28703107; rs13167038; rs35859367; rs35535163; rs5868180; rs34329719; rs34410141; rs13182805; rs1143234; rs35334435; rs34738106; rs7707973; rs35479721; rs9686434; rs35782047; rs13357023; rs35465707; rs6861588; rs9716677; rs1445949; rs28458370; rs11437091; rs12188697; rs694160; rs13171057; rs34683548; rs34220408; rs34129672; rs36013923; rs530284; rs1143235; rs6888675; rs28508224; rs34811771; rs34216373; rs11425439; rs34621078; rs3061713; rs13172552; rs11749523; rs35530997; rs1974837; rs1506560; rs35291504; rs10043736; rs10036938; rs35614028; rs34852844; rs34886659; rs3989118; rs28729916; rs13187814; rs3840338; rs35004795; rs34244304; rs4493634; rs10636912; rs34445163; rs28373501; rs1506559; rs12374472; rs10704375; rs13355311; rs10056445; rs41404047; rs1809012; rs28435556; rs549097; rs35716104; rs35148987; rs34763664; rs2572933; rs13180070; rs13157337; rs35770645; rs11302070; rs10546090; rs829257; rs36047924; rs11451313; rs11402131; rs10057562; rs1006431; rs10069162; rs10071774; rs10077740; rs10471462; rs10472078; rs10472079; rs10472080; rs10491440; rs10491441; rs10491442; rs11740523; rs11950308; rs12653432; rs12655332; rs12655347; rs13173189; rs13173224; rs13177216; rs13177592; rs13185339; rs13190178; rs13190308; rs1395334; rs1498602; rs1498603; rs1498604; rs1498605; rs17439074; rs17775453; rs1948651; rs1995166; rs2279737; rs295943; rs295944; rs295945; rs295946; rs295947; rs296404; rs296405; rs2968017; rs34791515; rs4143654; rs4279299; rs4699934; rs4700319; rs702521; rs702522; rs702524; rs702525; rs702526; rs702527; rs702528; rs7706419

# Metabolic_Enzyme_92_General_References:
8413254; 8797812; 8125310; 9371713; 10913353; 12834813; 14517540

# Metabolic_Enzyme_92_References:
Not Available

# Metabolic_Enzyme_93_ID:
5909

# Metabolic_Enzyme_93_Name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

# Metabolic_Enzyme_93_Synonyms:
GMP-PDE gamma

# Metabolic_Enzyme_93_Gene_Name:
PDE6G

# Metabolic_Enzyme_93_Protein_Sequence:
>Retinal rod rhodopsinsensitive cGMP 3',5'cyclic phosphodiesterase subunit gamma
MNLEPPKAEFRSATRVAGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGL
GTDITVICPWEAFNHLELHELAQYGII

# Metabolic_Enzyme_93_Number_of_Residues:
87

# Metabolic_Enzyme_93_Molecular_Weight:
9643

# Metabolic_Enzyme_93_Theoretical_pI:
10.16

# Metabolic_Enzyme_93_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  cGMP-specific phosphodiesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_93_General_Function:
Not Available

# Metabolic_Enzyme_93_Specific_Function:
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones

# Metabolic_Enzyme_93_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_93_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_93_Pfam_Domain_Function:
PF04868:PDE6_gamma

# Metabolic_Enzyme_93_Signals:
None

# Metabolic_Enzyme_93_Transmembrane_Regions:
None

# Metabolic_Enzyme_93_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_93_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_93_GenBank_ID_Protein:
189703

# Metabolic_Enzyme_93_SwissProt_ID:
CNRG_HUMAN (P18545)

# Metabolic_Enzyme_93_swissprot_Name:
Not Available

# Metabolic_Enzyme_93_Genecard_id:
PDE6G

# Metabolic_Enzyme_93_Geneatlas_id:
PDE6G

# Metabolic_Enzyme_93_hgnc_id:
HGNC:8789

# Metabolic_Enzyme_93_PDB_ID:
Not Available

# Metabolic_Enzyme_93_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_93_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_93_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_93_Gene_Sequence:
>264 bp
ATGAACCTGGAACCGCCCAAGGCTGAGTTCCGGTCAGCCACCAGGGTGGCCGGGGGACCT
GTCACCCCCAGGAAAGGGCCCCCTAAATTTAAGCAGCGACAGACCAGGCAGTTCAAGAGC
AAGCCCCCAAAGAAAGGCGTTCAAGGGTTTGGGGACGACATCCCTGGAATGGAAGGCCTG
GGAACAGACATCACAGTCATCTGCCCTTGGGAGGCCTTCAACCACCTGGAGCTGCACGAG
CTGGCCCAATATGGCATCATCTAG

# Metabolic_Enzyme_93_GenBank_ID_Gene:
M36476

# Metabolic_Enzyme_93_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_93_Locus:
17q25

# Metabolic_Enzyme_93_SNPs:
rs3830068; rs1126818; rs8477; rs8908; rs3432; rs13372; rs11150803; rs7405790; rs7405798; rs7405870; rs1126835; rs12603868; rs7217415; rs7406825; rs11871837; rs7406828; rs8065526; rs11867395; rs12938981; rs11431043; rs7405799; rs34483867; rs35479959; rs36111499; rs7405655; rs12948839; rs3842709; rs12948797; rs35452055; rs12946993; rs12946445; rs2071451; rs34794441; rs35763415; rs11270790; rs8067026; rs7406904; rs34410653; rs8074225; rs35624022; rs7406891; rs12940128; rs12950388; rs11870066; rs8069538; rs8065141; rs11150804; rs11868728; rs34896443; rs35665020; rs35842897; rs6420484; rs6565616; rs6565617; rs7210026; rs7210043; rs7210193; rs7405629; rs7406678; rs7406705; rs7502320; rs7502869; rs9890264; rs9905410; rs9905639; rs9906358; rs9910935

# Metabolic_Enzyme_93_General_References:
2161380; 1965799; 8125719

# Metabolic_Enzyme_93_References:
Not Available

# Metabolic_Enzyme_94_ID:
5910

# Metabolic_Enzyme_94_Name:
Ubiquitin-conjugating enzyme E2 G2

# Metabolic_Enzyme_94_Synonyms:
Ubiquitin-protein ligase G2; Ubiquitin carrier protein G2

# Metabolic_Enzyme_94_Gene_Name:
UBE2G2

# Metabolic_Enzyme_94_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 G2
MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPAILSF
PLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSVEKIL
LSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQIVQKSLGL

# Metabolic_Enzyme_94_Number_of_Residues:
165

# Metabolic_Enzyme_94_Molecular_Weight:
18566

# Metabolic_Enzyme_94_Theoretical_pI:
4.34

# Metabolic_Enzyme_94_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_94_General_Function:
Not Available

# Metabolic_Enzyme_94_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Involved in endoplasmic reticulum-associated degradation (ERAD)

# Metabolic_Enzyme_94_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_94_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_94_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_94_Signals:
None

# Metabolic_Enzyme_94_Transmembrane_Regions:
None

# Metabolic_Enzyme_94_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_94_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_94_GenBank_ID_Protein:
3004909

# Metabolic_Enzyme_94_SwissProt_ID:
UB2G2_HUMAN (P60604)

# Metabolic_Enzyme_94_swissprot_Name:
Not Available

# Metabolic_Enzyme_94_Genecard_id:
UBE2G2

# Metabolic_Enzyme_94_Geneatlas_id:
UBE2G2

# Metabolic_Enzyme_94_hgnc_id:
HGNC:12483

# Metabolic_Enzyme_94_PDB_ID:
Not Available

# Metabolic_Enzyme_94_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_94_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_94_Subcellular_Location:
Not Available

# Metabolic_Enzyme_94_Gene_Sequence:
>498 bp
ATGGCGGGGACCGCGCTCAAGAGGCTGATGGCCGTGTACAAACAATTAACACTGAATCCT
CCGGAAGGAATTGTAGCAGGCCCCATGAATGAAGAGAACTTTTTTGAATGGGAGGCATTG
ATCATGGGCCCAGAAGACACCTGCTTTGAGTTTGGTGTTTTTCCTGCCATCCTGAGTTTC
CCACTTGATTACCCGTTAAGTCCCCCAAAGATGAGATTTACCTGTGAGATGTTTCATCCC
AACATCTACCCTGATGGGAGAGTCTGCATTTCCATCCTCCACGCCCCAGGCGATGACCCC
CATGGGCTACGAGAGCAGCCGGAGCGGTGGAGTCCTGTGCAGAGTGTGGAGAAGATCCTG
CTGTCGGTGGTGAGCATGCTGGCAGAGCCCAATGACGAAAGTGGAGCTAACGTGGATGCG
TCCAAAATGTGGCGCGATGACCGGGAGCAGTTCTATAAGATTGCCAAGCAGATCGTCCAG
AAGTCTCTGGGACTGTGA

# Metabolic_Enzyme_94_GenBank_ID_Gene:
AF032456

# Metabolic_Enzyme_94_Chromosome_Location:
Not Available

# Metabolic_Enzyme_94_Locus:
Not Available

# Metabolic_Enzyme_94_SNPs:
rs2838677; rs2838689; rs1060564; rs2838678; rs1141; rs2838687; rs235271; rs2838676; rs760431; rs4818975; rs235275; rs11569; rs235356; rs760432; rs8131092; rs9981344; rs7281735; rs235355; rs173097; rs9978131; rs235354; rs9984290; rs8103; rs11908708; rs2838688; rs186848; rs8131444; rs235269; rs235270; rs235267; rs235273; rs235274; rs235268; rs184634; rs13433413; rs17289578; rs4818734; rs13049333; rs235369; rs184633; rs8132961; rs235272; rs235358; rs235359; rs2838683; rs2838686; rs2838681; rs2329900; rs2838679; rs235360; rs2838685; rs2838684; rs235362; rs1368991; rs7364120; rs1109280; rs235361; rs2838682; rs2329899; rs876812; rs3788140; rs235367; rs2294157; rs4239838; rs183518; rs1821431; rs8132011; rs235357; rs11702743; rs235364; rs1347324; rs180317; rs2294158; rs235352; rs235353; rs2838691; rs84188; rs6518204; rs2838690; rs235351; rs4818731; rs3788138; rs2274803; rs8126509; rs9977676; rs235291; rs3179387; rs11545486; rs35242981; rs1071792; rs34837820; rs2570974; rs35406176; rs35546235; rs13052399; rs34048289; rs34361555; rs428428; rs34942803; rs2008604; rs35849580; rs13051414; rs13051406; rs34142774; rs1137677; rs34632868; rs13051415; rs28680339; rs35144858; rs7509916; rs170959; rs12626275; rs11088963; rs34887102; rs36028785; rs11545488; rs35868008; rs28728356; rs3838126; rs235368; rs34716840; rs11391154; rs4569556; rs235365; rs34633573; rs11442914; rs727608; rs35209090; rs11373620; rs35371924; rs28668706; rs11448217; rs4818976; rs235363; rs34662670; rs33935066; rs7510415; rs35437707; rs8133388; rs7510280; rs35933313; rs5844198; rs13051119; rs35627976; rs35453630; rs235366; rs10535511; rs170964; rs173095; rs3788137; rs235350; rs34869097; rs34800103; rs1004997; rs10483079; rs1051331; rs11702874; rs17289745; rs180313; rs2016874; rs2017089; rs2329902; rs235292; rs235293; rs2838673; rs2838674; rs2838675; rs2838692; rs2838693; rs2838694; rs2838695; rs3746969; rs3788132; rs3788133; rs3788134; rs3788135; rs3788136; rs3827259; rs434608; rs4437050; rs4818973; rs4818977; rs657730; rs658657; rs674696; rs733161; rs741948; rs760430; rs8130842; rs8133039; rs8645; rs873301; rs885655; rs885656; rs9984357

# Metabolic_Enzyme_94_General_References:
9693041; 10830953

# Metabolic_Enzyme_94_References:
Not Available

# Metabolic_Enzyme_95_ID:
5911

# Metabolic_Enzyme_95_Name:
ADP-ribose pyrophosphatase, mitochondrial precursor

# Metabolic_Enzyme_95_Synonyms:
ADP-ribose diphosphatase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase; ADP-ribose phosphohydrolase; Nucleoside diphosphate- linked moiety X motif 9; Nudix motif 9

# Metabolic_Enzyme_95_Gene_Name:
NUDT9

# Metabolic_Enzyme_95_Protein_Sequence:
>ADPribose pyrophosphatase, mitochondrial precursor
MAGRLLGKALAAVSLSLALASVTIRSSRCRGIQAFRNSFSSSWFHLNTNVMSGSNGSKEN
SHNKARTSPYPGSKVERSQVPNEKVGWLVEWQDYKPVEYTAVSVLAGPRWADPQISESNF
SPKFNEKDGHVERKSKNGLYEIENGRPRNPAGRTGLVGRGLLGRWGPNHAADPIITRWKR
DSSGNKIMHPVSGKHILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKREFGEEALNSLQ
KTSAEKREIEEKLHKLFSQDHLVIYKGYVDDPRNTDNAWMETEAVNYHDETGEIMDNLML
EAGDDAGKVKWVDINDKLKLYASHSQFIKLVAEKRDAHWSEDSEADCHAL

# Metabolic_Enzyme_95_Number_of_Residues:
350

# Metabolic_Enzyme_95_Molecular_Weight:
39125

# Metabolic_Enzyme_95_Theoretical_pI:
8.45

# Metabolic_Enzyme_95_GO_Classification:
Not Available

# Metabolic_Enzyme_95_General_Function:
Not Available

# Metabolic_Enzyme_95_Specific_Function:
Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'- phosphate

# Metabolic_Enzyme_95_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_95_Reaction:
ADP-ribose + H2O = AMP + D-ribose 5-phosphate

# Metabolic_Enzyme_95_Pfam_Domain_Function:
PF00293:NUDIX

# Metabolic_Enzyme_95_Signals:
1-20

# Metabolic_Enzyme_95_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_95_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_95_EC_Link:
EC 3.6.1.13

# Metabolic_Enzyme_95_GenBank_ID_Protein:
14160858

# Metabolic_Enzyme_95_SwissProt_ID:
NUDT9_HUMAN (Q9BW91)

# Metabolic_Enzyme_95_swissprot_Name:
Not Available

# Metabolic_Enzyme_95_Genecard_id:
NUDT9

# Metabolic_Enzyme_95_Geneatlas_id:
NUDT9

# Metabolic_Enzyme_95_hgnc_id:
HGNC:8056

# Metabolic_Enzyme_95_PDB_ID:
1QVJ

# Metabolic_Enzyme_95_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_95_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_95_Subcellular_Location:
Isoform 1:Mitochondrion

# Metabolic_Enzyme_95_Gene_Sequence:
>1053 bp
ATGGCGGGACGCCTCCTGGGAAAGGCTTTAGCCGCGGTGTCTCTCTCTCTGGCCTTGGCC
TCTGTGACTATCAGGTCCTCGCGCTGCCGCGGCATCCAGGCGTTCAGAAACTCGTTTTCA
TCTTCTTGGTTTCATCTTAATACCAACGTCATGTCTGGTTCTAATGGTTCCAAAGAAAAT
TCTCACAATAAGGCTCGGACGTCTCCTTACCCAGGTTCAAAAGTTGAACGAAGCCAGGTT
CCTAATGAGAAAGTGGGCTGGCTTGTTGAGTGGCAAGACTATAAGCCTGTGGAATACACT
GCAGTCTCTGTCTTGGCTGGACCCAGGTGGGCAGATCCTCAGATCAGTGAAAGTAATTTT
TCTCCCAAGTTTAACGAAAAGGATGGGCATGTTGAGAGAAAGAGCAAGAATGGCCTGTAT
GAGATTGAAAATGGAAGACCGAGAAATCCTGCAGGACGGACTGGACTGGTGGGCCGGGGG
CTTTTGGGGCGATGGGGCCCAAATCACGCTGCAGATCCCATTATAACCAGATGGAAAAGG
GATAGCAGTGGAAATAAAATCATGCATCCTGTTTCTGGGAAGCATATCTTACAATTTGTT
GCAATAAAAAGGAAAGACTGTGGAGAATGGGCAATCCCAGGGGGGATGGTGGATCCAGGA
GAGAAGATTAGTGCCACACTGAAAAGAGAATTTGGTGAGGAAGCTCTCAACTCCTTACAG
AAAACCAGTGCTGAGAAGAGAGAAATAGAGGAAAAGTTGCACAAACTCTTCAGCCAAGAC
CACCTAGTGATATATAAGGGATATGTTGATGATCCTCGAAACACTGATAATGCATGGATG
GAGACAGAAGCTGTGAACTACCATGACGAAACAGGTGAGATAATGGATAATCTTATGCTA
GAAGCTGGAGATGATGCTGGAAAAGTGAAATGGGTGGACATCAATGATAAACTGAAGCTT
TATGCCAGTCACTCTCAATTCATCAAACTTGTGGCTGAGAAACGAGATGCACACTGGAGC
GAGGACTCTGAAGCTGACTGCCATGCGTTGTAG

# Metabolic_Enzyme_95_GenBank_ID_Gene:
AY026252

# Metabolic_Enzyme_95_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_95_Locus:
4q22.1

# Metabolic_Enzyme_95_SNPs:
rs11937770; rs4693163; rs7660018; rs7673763; rs10027786; rs10017282; rs11097154; rs34208894; rs28372776; rs7680878; rs4493500; rs1128060; rs13143153; rs10034240; rs6837468; rs10025902; rs7673045; rs11097155; rs7666886; rs6816562; rs7665109; rs6816563; rs13136775; rs10213468; rs6816224; rs6531994; rs6531997; rs10008963; rs4324526; rs6855378; rs11936844; rs12650763; rs4642210; rs12640894; rs10015443; rs7668956; rs28624955; rs13104303; rs7690728; rs13119333; rs9994244; rs13130945; rs7660608; rs9654160; rs7665115; rs13122902; rs10035024; rs12651034; rs6531995; rs12498189; rs11935226; rs11945232; rs11936545; rs6844206; rs28372775; rs35647956; rs34378436; rs13143137; rs13136486; rs35385711; rs35766207; rs28516874; rs35340619; rs13151503; rs34532341; rs35703219; rs33962420; rs7681421; rs28439403; rs10030035; rs6842852; rs13134914; rs35991122; rs13129115; rs9995987; rs28493315; rs35968928; rs10155178; rs28502849; rs34908201; rs35914458; rs28736552; rs10002390; rs28762371; rs11398519; rs6148559; rs35889524; rs35974628; rs35045058; rs10553683; rs7677249; rs34022733; rs34893260; rs11321653; rs35763051; rs28712618; rs6827567; rs11408760; rs6829145; rs35132503; rs7674852; rs7688288; rs33947753; rs13145111; rs4693817; rs35076796; rs28437709; rs9654159; rs35991708; rs11310721; rs35050437; rs34737452; rs35679067; rs34006658; rs35607673; rs28529046; rs13124614; rs35652878; rs28535549; rs35738171; rs35189488; rs35137978; rs11938995; rs34764635; rs34861438; rs34248291; rs11097156; rs33924039; rs9999899; rs35766329; rs5860073; rs34697941; rs34367002; rs34414336; rs28493566; rs9998212; rs35649088; rs34596563; rs35531610; rs13115687; rs35364531; rs34608747; rs36055576; rs28609242; rs28406846; rs35227897; rs10084883; rs6831350; rs6831120; rs10009948; rs10013990; rs10017783; rs10024099; rs10032572; rs11936273; rs11936366; rs11947959; rs12503328; rs12640451; rs12648606; rs12651667; rs13111348; rs13133003; rs34485767; rs4314250; rs4364226; rs4405983; rs6531988; rs6531990; rs6818444; rs6825532; rs6826257; rs6833270; rs6833835; rs6838776; rs6839314; rs6854710; rs7691533; rs9307036; rs9968511; rs9990749; rs9998007; rs9998122

# Metabolic_Enzyme_95_General_References:
11385575; 12975309

# Metabolic_Enzyme_95_References:
Not Available

# Metabolic_Enzyme_96_ID:
5237

# Metabolic_Enzyme_96_Name:
Cytosolic purine 5'-nucleotidase

# Metabolic_Enzyme_96_Synonyms:
5'-nucleotidase cytosolic II

# Metabolic_Enzyme_96_Gene_Name:
NT5C2

# Metabolic_Enzyme_96_Protein_Sequence:
>Cytosolic purine 5'nucleotidase
MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVY
KSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLV
CAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTS
CETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMK
EVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGT
VLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKS
KKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQ
RRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAA
HVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLA
PQEITHCHDEDDDEEEEEEEE

# Metabolic_Enzyme_96_Number_of_Residues:
561

# Metabolic_Enzyme_96_Molecular_Weight:
64970

# Metabolic_Enzyme_96_Theoretical_pI:
6.05

# Metabolic_Enzyme_96_GO_Classification:
Not Available

# Metabolic_Enzyme_96_General_Function:
Not Available

# Metabolic_Enzyme_96_Specific_Function:
May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides

# Metabolic_Enzyme_96_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_96_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_96_Pfam_Domain_Function:
PF05761:5_nucleotid

# Metabolic_Enzyme_96_Signals:
None

# Metabolic_Enzyme_96_Transmembrane_Regions:
None

# Metabolic_Enzyme_96_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_96_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_96_GenBank_ID_Protein:
633071

# Metabolic_Enzyme_96_SwissProt_ID:
5NTC_HUMAN (P49902)

# Metabolic_Enzyme_96_swissprot_Name:
Not Available

# Metabolic_Enzyme_96_Genecard_id:
NT5C2

# Metabolic_Enzyme_96_Geneatlas_id:
NT5C2

# Metabolic_Enzyme_96_hgnc_id:
HGNC:8022

# Metabolic_Enzyme_96_PDB_ID:
Not Available

# Metabolic_Enzyme_96_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_96_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_96_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_96_Gene_Sequence:
>1686 bp
ATGTCGACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGAT
AAGCATGCCCTGAAAAAGTATCGTCGAGAAGCCTATCATCGGGTGTTTGTGAACCGAAGT
TTAGCAATGGAAAAGATAAAGTGTTTTGGTTTTGATATGGATTATACCCTTGCTGTGTAC
AAGTCCCCAGAGTATGAGTCCCTTGGTTTTGAGCTTACTGTGGAGAGATTAGTTTCTATT
GGCTATCCCCAGGAGTTGCTCAGCTTTGCTTATGATTCTACATTCCCTACCAGGGGACTT
GTCTTTGACACACTGTATGGAAATCTTTTGAAAGTCGATGCCTATGGAAACCTCTTGGTC
TGTGCACATGGATTTAACTTTATAAGGGGACCAGAAACTAGAGAACAGTATCCAAATAAA
TTTATCCAGCGAGATGATACTGAAAGATTTTACATTCTGAACACACTATTCAACCTACCA
GAGACCTACCTGTTGGCCTGCCTAGTAGATTTTTTTACTAATTGTCCCAGATATACCAGT
TGTGAAACAGGATTTAAAGATGGGGACCTCTTCATGTCCTACCGGAGTATGTTCCAGGAT
GTAAGAGATGCTGTTGACTGGGTTCATTACAAGGGCTCCCTTAAGGAAAAGACAGTTGAA
AATCTTGAGAAGTATGTAGTCAAAGATGGAAAACTGCCTTTGCTTCTGAGCCGGATGAAG
GAAGTAGGGAAAGTATTTCTTGCTACCAACAGTGACTATAAATATACAGATAAAATTATG
ACTTACCTGTTTGACTTCCCACATGGCCCCAAGCCTGGGAGCTCCCATCGACCATGGCAG
TCCTACTTTGACTTGATCTTGGTGGATGCACGGAAACCACTCTTTTTTGGAGAAGGCACA
GTACTGCGTCAGGTGGATACTAAAACTGGCAAGCTGAAAATTGGTACCTACACAGGGCCC
CTACAGCATGGTATCGTCTACTCAGGAGGTTCTTCTGATACGATCTGTGACCTGTTGGGA
GCCAAGGGAAAAGACATTTTGTATATTGGAGATCACATTTTTGGGGACATTTTAAAATCA
AAGAAACGGCAAGGGTGGCGAACTTTTTTGGTGATTCCTGAACTCGCACAGGAGCTACAT
GTCTGGACTGACAAGAGTTCACTTTTCGAAGAACTTCAGAGCTTGGATATTTTCTTGGCT
GAACTCTACAAGCATCTTGACAGCAGTAGCAATGAGCGTCCAGACATCAGTTCCATCCAG
AGACGTATTAAGAAAGTAACTCATGACATGGACATGTGCTATGGGATGATGGGAAGCCTG
TTTCGCAGTGGCTCCCGGCAGACCCTTTTTGCCAGTCAAGTGATGCGTTATGCTGACCTC
TATGCAGCATCTTTCATCAACCTGCTGTATTACCCTTTCAGCTACCTCTTCAGGGCTGCC
CATGTCTTGATGCCTCATGAATCAACGGTGGAGCACACACACGTAGATATCAATGAGATG
GAGTCTCCTCTTGCCACCCGGAACCGCACATCAGTGGATTTCAAAGACACTGACTACAAG
CGGCACCAGCTGACACGGTCAATTAGTGAGATTAAACCTCCCAACCTCTTCCCACTGGCC
CCCCAGGAAATTACACACTGCCATGACGAAGATGATGATGAAGAGGAGGAGGAGGAGGAA
GAATAA

# Metabolic_Enzyme_96_GenBank_ID_Gene:
D38524

# Metabolic_Enzyme_96_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_96_Locus:
10q24.32-q24.33

# Metabolic_Enzyme_96_SNPs:
rs12262171; rs3740387; rs12253627; rs10786736; rs8139; rs7917650; rs10786741; rs7920251; rs10430665; rs7916854; rs12573199; rs11191598; rs1163238; rs12573200; rs10883843; rs7092407; rs12573221; rs4917997; rs11191593; rs11191596; rs10786744; rs1163236; rs10883842; rs10786742; rs10786743; rs7075552; rs7077097; rs2863728; rs3758543; rs7077291; rs10748838; rs3087681; rs12240508; rs732998; rs10883830; rs7899084; rs2274340; rs2182348; rs2066322; rs7908960; rs7912517; rs7067970; rs3740386; rs7896547; rs11191554; rs1163249; rs2281877; rs2863727; rs3781281; rs2274341; rs2148198; rs7897663; rs3781282; rs10883832; rs1926029; rs1935323; rs1926030; rs746293; rs6584539; rs2066323; rs9919482; rs3740385; rs12773916; rs12414232; rs10786737; rs12413046; rs12412038; rs2274339; rs11598702; rs1541213; rs11191580; rs11191553; rs10509765; rs10509766; rs3977751; rs12220375; rs4917996; rs7896433; rs6584540; rs1926037; rs3736922; rs11191577; rs2148197; rs11191561; rs7080935; rs11191555; rs10883833; rs12219304; rs1926036; rs7913920; rs10883834; rs11191558; rs11191582; rs11191589; rs10883831; rs12220743; rs10786738; rs11191560; rs10748837; rs11191578; rs3781280; rs7896519; rs12217501; rs11191573; rs7067741; rs6584541; rs7067663; rs2148200; rs10883840; rs11191583; rs12415199; rs9919485; rs11191557; rs17094683; rs7895154; rs12355120; rs2153774; rs10786739; rs7915816; rs7081075; rs1807298; rs3861984; rs11191572; rs12571568; rs12416331; rs11191586; rs10883839; rs12766205; rs1163239; rs10883837; rs11191584; rs1163247; rs17115452; rs11191556; rs7909022; rs12775302; rs9633712; rs11191581; rs11191576; rs10883836; rs11191549; rs7095304; rs10883845; rs11191550; rs11191548; rs11191602; rs10748839; rs1141101; rs1055812; rs1141100; rs1141098; rs1141099; rs34351688; rs34394526; rs34058246; rs11191594; rs35224704; rs34747231; rs12774207; rs11191595; rs34699185; rs11280184; rs1163237; rs7073259; rs34064597; rs11191601; rs35525740; rs35291480; rs12264098; rs35978588; rs12241986; rs7091462; rs12774182; rs34756486; rs35695488; rs12252236; rs3834416; rs11191600; rs34136949; rs7080242; rs12763243; rs34003851; rs11191585; rs11191551; rs36111455; rs34966121; rs35464534; rs35541240; rs11191571; rs35913488; rs34223002; rs11440429; rs41287482; rs35653865; rs34963818; rs11191559; rs11191568; rs35436872; rs17795366; rs1163246; rs34060908; rs34963563; rs34915846; rs12780509; rs2153773; rs34211645; rs3736924; rs34758128; rs36059537; rs35302704; rs12255989; rs34104646; rs11191574; rs11191564; rs35745742; rs34644789; rs5787481; rs34863357; rs11191590; rs12774840; rs2148196; rs12763944; rs3215816; rs34207290; rs35752695; rs34445719; rs28419708; rs4421684; rs28516969; rs12265498; rs12767422; rs12772228; rs34908445; rs11191570; rs17115449; rs35195396; rs12243923; rs10883835; rs12779263; rs11302933; rs7091173; rs11375439; rs7071103; rs35146429; rs35338839; rs34268365; rs34130454; rs35898850; rs3861983; rs28404041; rs35621207; rs3736923; rs5787482; rs7075048; rs34307431; rs35348020; rs34349473; rs1773930; rs11191566; rs34870452; rs35078544; rs35123178; rs12265545; rs1163241; rs3949893; rs7904067; rs12775841; rs35821867; rs12775904; rs7915032; rs5028036; rs35254502; rs1163248; rs35365027; rs34876862; rs11191565; rs12772280; rs10709724; rs35085852; rs35351555; rs12774513; rs10710371; rs11296588; rs12243903; rs28605898; rs34241930; rs34549427; rs11451961; rs34403968; rs12761657; rs34397864; rs3062737; rs36092020; rs35109679; rs34011916; rs34435560; rs11191562; rs4917383; rs34067380; rs34202831; rs11191563; rs2148199; rs34133379; rs35763505; rs12414385; rs1163240; rs12262258; rs11191588; rs34664715; rs12414374; rs35133717; rs3837340; rs10614009; rs2153772; rs11191587; rs11403586; rs11191575; rs1060240; rs34588165; rs11191552; rs41317254; rs1163245; rs1064099; rs12268552; rs34833988; rs11191603; rs12253716; rs12412924; rs3841710; rs34551510; rs12246784; rs12781668; rs1064098; rs10458729; rs10786740; rs10786745; rs10883829; rs10883841; rs11191547; rs1163235; rs12261294; rs12571345; rs12785223; rs17115427; rs4307650; rs4917382; rs4917995; rs7074395; rs7092200; rs726010; rs763914; rs7921996; rs943035

# Metabolic_Enzyme_96_General_References:
7999131

# Metabolic_Enzyme_96_References:
Not Available

# Metabolic_Enzyme_97_ID:
5912

# Metabolic_Enzyme_97_Name:
Adenosine kinase

# Metabolic_Enzyme_97_Synonyms:
AK; Adenosine 5'-phosphotransferase

# Metabolic_Enzyme_97_Gene_Name:
ADK

# Metabolic_Enzyme_97_Protein_Sequence:
>Adenosine kinase
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAED
KHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKA
AEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKAR
VCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGN
ETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFA
VLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPD
FH

# Metabolic_Enzyme_97_Number_of_Residues:
362

# Metabolic_Enzyme_97_Molecular_Weight:
40546

# Metabolic_Enzyme_97_Theoretical_pI:
6.67

# Metabolic_Enzyme_97_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleoside kinase activity
Function:  adenosine kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  purine salvage
Process:  purine ribonucleoside salvage
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_97_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_97_Specific_Function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides

# Metabolic_Enzyme_97_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_97_Reaction:
ATP + adenosine = ADP + AMP

# Metabolic_Enzyme_97_Pfam_Domain_Function:
PF00294:PfkB

# Metabolic_Enzyme_97_Signals:
None

# Metabolic_Enzyme_97_Transmembrane_Regions:
None

# Metabolic_Enzyme_97_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_97_EC_Link:
EC 2.7.1.20

# Metabolic_Enzyme_97_GenBank_ID_Protein:
1224125

# Metabolic_Enzyme_97_SwissProt_ID:
ADK_HUMAN (P55263)

# Metabolic_Enzyme_97_swissprot_Name:
Not Available

# Metabolic_Enzyme_97_Genecard_id:
ADK

# Metabolic_Enzyme_97_Geneatlas_id:
ADK

# Metabolic_Enzyme_97_hgnc_id:
HGNC:257

# Metabolic_Enzyme_97_PDB_ID:
1BX4

# Metabolic_Enzyme_97_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_97_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_97_Subcellular_Location:
Not Available

# Metabolic_Enzyme_97_Gene_Sequence:
>1038 bp
ATGACGTCAGTCAGAGAAAATATTCTCTTTGGAATGGGAAATCCTCTGCTTGACATCTCT
GCTGTAGTGGACAAAGATTTCCTTGATAAGTATTCTCTGAAACCAAATGACCAAATCTTG
GCTGAAGACAAACACAAGGAACTGTTTGATGAACTTGTGAAAAAATTCAAAGTCGAATAT
CATGCTGGTGGCTCTACCCAGAATTCAATTAAAGTGGCTCAGTGGATGATTCAACAGCCA
CACAAAGCAGCAACATTTTTTGGATGCATTGGGATAGATAAATTTGGGGAGATCCTGAAG
AGAAAAGCTGCTGAAGCCCATGTGGATGCTCATTACTACGAGCAGAATGAGCAGCCAACA
GGAACTTGTGCTGCATGCATCACTGGTGACAACAGGTCCCTCATAGCTAATCTTGCTGCT
GCCAATTGTTATAAAAAGGAAAAACATCTTGATCTGGAGAAAAACTGGATGTTGGTAGAA
AAAGCAAGAGTTTGTTATATAGCAGGCTTTTTTCTTCACGTTTCCCCAGAGTCAGTATTA
AAGGTGGCTCACCATGCTTCTGAAAACAACAGGATTTTCACTTTGAATCTATCTGCACCG
TTTATTAGCCAGTTCTACAAGGAATCATTGATGAAAGTTATGCCTTATGTTGATATACTT
TTTGGAAATGAGACAGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGAC
ATTAAAGAGATAGCCAAAAAGACACAAGCCCTGCCAAAGATGAACTCAAAGAGGCAGCGA
ATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACT
GCTTTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGAT
GCATTTGTTGGAGGTTTTCTGTCTCAACTGGTCTCTGACAAGCCTCTGACTGAATGTATC
CGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAG
AAGCCAGACTTCCACTGA

# Metabolic_Enzyme_97_GenBank_ID_Gene:
U50196

# Metabolic_Enzyme_97_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_97_Locus:
10q22|10q11-q24

# Metabolic_Enzyme_97_SNPs:
rs16931480; rs1189553; rs10824095; rs2169682; rs2894236; rs1904060; rs1904067; rs1904066; rs1871088; rs1908335; rs719624; rs1871085; rs1871087; rs2894234; rs1904064; rs871267; rs10824166; rs7350403; rs10824172; rs7090732; rs10824087; rs7894466; rs2395096; rs1898057; rs6480741; rs10740440; rs6480745; rs7098277; rs10509348; rs7079515; rs7909197; rs7899674; rs6480721; rs11597563; rs10740439; rs4451661; rs1898055; rs7079633; rs2126768; rs4390292; rs10824163; rs6480734; rs7083427; rs2169683; rs2395092; rs7072264; rs7092245; rs7922519; rs4746191; rs10824183; rs10762587; rs7100452; rs7094239; rs4564273; rs1898056; rs7096553; rs4237279; rs7087566; rs11000920; rs10762595; rs7068789; rs7100550; rs6480733; rs10762582; rs4323810; rs7098200; rs2306161; rs10824170; rs7084786; rs10824165; rs10762621; rs7923414; rs10824182; rs7916445; rs6480742; rs7082003; rs961321; rs10762624; rs10824094; rs7093532; rs7908160; rs2395095; rs6480749; rs4320897; rs10762606; rs9665468; rs10733903; rs10762601; rs11001022; rs10824133; rs10824119; rs4077282; rs10509350; rs10762640; rs4746181; rs10824195; rs7918318; rs4459229; rs6480739; rs4261231; rs10762605; rs7082872; rs3862535; rs6480727; rs7918927; rs2395087; rs10824120; rs10824186; rs7078351; rs7087368; rs7914902; rs4746214; rs1904061; rs11001105; rs10762615; rs7083534; rs10824177; rs7085940; rs10740437; rs4746182; rs10740436; rs11001043; rs2126760; rs11818050; rs6480726; rs10762612; rs7895133; rs7075643; rs7095850; rs10740443; rs4746221; rs10824185; rs4353215; rs2395097; rs2126763; rs7924176; rs7910153; rs7919277; rs7072220; rs10762636; rs10762622; rs11000931; rs4745739; rs3781255; rs10762588; rs10824138; rs10824218; rs10762638; rs2126765; rs6480731; rs4745749; rs4338470; rs7074939; rs7079709; rs4746207; rs7921187; rs11819334; rs11000960; rs11001089; rs4561146; rs11815260; rs10824193; rs10762629; rs10824135; rs7917790; rs10824105; rs11597376; rs11817779; rs7897750; rs11593868; rs4746216; rs7919166; rs11001052; rs12573619; rs10762620; rs10824197; rs7071324; rs10762596; rs11816566; rs7912162; rs7072504; rs11813905; rs10824161; rs2126767; rs10762603; rs10733895; rs7097320; rs11813953; rs7072012; rs10824122; rs7909915; rs12573590; rs4746177; rs10762639; rs726120; rs10824188; rs7913606; rs4745743; rs10740423; rs11001020; rs7075393; rs4746212; rs7923626; rs4746190; rs1556822; rs946186; rs7899920; rs10762630; rs10824134; rs12784355; rs16931294; rs2117791; rs2078036; rs12571088; rs10762607; rs10824192; rs10824137; rs11001028; rs7477710; rs10824098; rs946185; rs11814981; rs11001046; rs7916143; rs6480732; rs4745750; rs7914995; rs10509347; rs7069460; rs10740441; rs7075956; rs10762591; rs4376843; rs4281434; rs10824208; rs7901031; rs11000964; rs11818752; rs10824101; rs7099494; rs1904062; rs10762635; rs11813032; rs10824106; rs10824160; rs2126766; rs11001002; rs10762611; rs11000925; rs6480724; rs10762599; rs16931395; rs11000911; rs7917666; rs7896617; rs11816554; rs11000939; rs958620; rs12416316; rs10762641; rs10824130; rs7073742; rs12355686; rs11813815; rs2164367; rs11001109; rs9665469; rs7098337; rs10824124; rs10762619; rs10824092; rs1904065; rs12772532; rs10824174; rs7901055; rs4639878; rs1556821; rs11814426; rs6480723; rs12360119; rs10824152; rs11813920; rs10824164; rs7073340; rs10824143; rs10824103; rs4489684; rs10824210; rs12570185; rs16931536; rs1993861; rs10824151; rs12571589; rs16931460; rs11001005; rs10824144; rs7923592; rs11598232; rs10762626; rs10824128; rs10762581; rs7084139; rs1556820; rs1904058; rs10509351; rs7100084; rs11000924; rs11001018; rs12569971; rs7895587; rs2395078; rs12416497; rs10762631; rs11001053; rs11814705; rs11814063; rs10762593; rs9971034; rs16931332; rs11815536; rs11001111; rs11001007; rs4746196; rs7920097; rs16931462; rs7097778; rs12573807; rs11001099; rs11001092; rs11813221; rs7073139; rs11001034; rs12572721; rs10824102; rs1904063; rs11001004; rs10824108; rs10509349; rs10824194; rs10733904; rs10740432; rs6480740; rs3862536; rs12573198; rs7896660; rs11000922; rs10762600; rs7089391; rs12412109; rs10824096; rs10824153; rs7476181; rs11001047; rs6480729; rs10740420; rs4746192; rs7896152; rs7906603; rs7894143; rs10824221; rs2894235; rs10762608; rs7086014; rs10824129; rs11001096; rs7915999; rs7902519; rs4746188; rs11812862; rs2131955; rs2126769; rs6480722; rs11598022; rs10824146; rs10824090; rs12415957; rs11812826; rs12412071; rs4745751; rs7084204; rs7087290; rs13376718; rs10762577; rs7914783; rs10824154; rs12243059; rs7088329; rs11001029; rs11000921; rs10762586; rs1908333; rs11000928; rs7905039; rs35074621; rs12357589; rs11000948; rs10740431; rs11000997; rs11001006; rs7895292; rs11812696; rs12573068; rs11000914; rs7089625; rs7081350; rs7074449; rs11001045; rs4501938; rs7922635; rs7898073; rs7903786; rs10762637; rs12220238; rs12251845; rs12217890; rs12259556; rs6480748; rs11001115; rs16931364; rs11001059; rs10762583; rs11000899; rs11000966; rs10762613; rs4746194; rs4341485; rs6480744; rs9664463; rs12261738; rs12360399; rs12572648; rs7919517; rs11001102; rs10128407; rs10824097; rs11001085; rs12360087; rs4746180; rs6480728; rs12573347; rs11001014; rs11594742; rs11000977; rs10824107; rs10824198; rs11599616; rs10824147; rs16931492; rs10824212; rs4615968; rs12268556; rs11000996; rs4745738; rs12359456; rs16931504; rs11001003; rs956118; rs12415743; rs12261586; rs7091715; rs12356618; rs11001114; rs1871086; rs12241337; rs12569368; rs11001103; rs10740421; rs6480730; rs9299518; rs7900243; rs10824117; rs12254109; rs4746189; rs7897539; rs10762585; rs11000951; rs10824113; rs10824104; rs16931528; rs11817059; rs4745744; rs16931523; rs11597443; rs10824148; rs16931525; rs16931367; rs11000988; rs10762602; rs6480746; rs7905536; rs10762618; rs12256590; rs7069107; rs10824142; rs12098284; rs7091719; rs11819665; rs11000959; rs7091300; rs11819705; rs16931516; rs12252558; rs16931474; rs7919010; rs10824123; rs7913178; rs11000909; rs11000915; rs12243409; rs12572696; rs7920185; rs7897778; rs12569733; rs7067813; rs4746198; rs7096664; rs16931341; rs7094284; rs7903760; rs11000945; rs11001015; rs7088944; rs7897643; rs1908334; rs10824111; rs12415794; rs11001090; rs12217753; rs11591270; rs16931520; rs4745740; rs7088149; rs11000927; rs4746202; rs7076721; rs16931511; rs9651336; rs16931546; rs12779371; rs7902089; rs12569695; rs12253120; rs9664464; rs946184; rs10824116; rs10762614; rs12416580; rs4746209; rs11598266; rs4746210; rs7921832; rs16931468; rs11818734; rs10824169; rs11000992; rs7085860; rs11000936; rs11819396; rs4331029; rs10824136; rs10740442; rs1416101; rs10762594; rs11812834; rs12569856; rs12775658; rs10824171; rs7904939; rs10824140; rs7073432; rs16931449; rs12268312; rs10824110; rs11001112; rs11001078; rs7073227; rs10824099; rs12414029; rs4745747; rs7920006; rs4745745; rs12260506; rs12359289; rs12415761; rs11000990; rs11001087; rs4341483; rs11814484; rs11817882; rs11000901; rs11000980; rs11000946; rs12355188; rs7901569; rs10824112; rs10824100; rs16931465; rs10824149; rs2395091; rs10430473; rs11595136; rs11000999; rs10824109; rs10824168; rs1531; rs10430521; rs4745741; rs12242776; rs7895061; rs12773903; rs10762598; rs10824209; rs7905662; rs11815035; rs12354678; rs10824220; rs12098289; rs4746197; rs11000994; rs7099552; rs7069901; rs11000912; rs7071823; rs10824175; rs7083605; rs4746187; rs12569670; rs12356350; rs7918573; rs10824115; rs10824181; rs12570624; rs7092741; rs10824203; rs11819074; rs11001031; rs7910626; rs12415736; rs10762609; rs11001027; rs12268597; rs11001016; rs4746218; rs12570022; rs11000941; rs11000986; rs10824139; rs7086415; rs12354659; rs17747401; rs2126764; rs11599320; rs12414489; rs7080815; rs10824118; rs10824091; rs7901524; rs11812815; rs12572580; rs16931477; rs10762584; rs7904489; rs4745752; rs7906759; rs12572155; rs7084146; rs11516630; rs7901242; rs11001013; rs7074327; rs4746215; rs7898517; rs10824088; rs10824167; rs10824125; rs10824132; rs10824141; rs11599829; rs11000962; rs11594739; rs10824121; rs11813394; rs12357370; rs11000900; rs7904773; rs10824211; rs10762589; rs11000947; rs7091823; rs12252705; rs11000981; rs7087567; rs11001048; rs16931519; rs7918003; rs16931521; rs7085334; rs12265663; rs10762617; rs16931527; rs11001116; rs12411935; rs12779309; rs4746211; rs7898405; rs12242814; rs10762592; rs10762616; rs11001019; rs10430474; rs2395093; rs10824202; rs1538311; rs10824114; rs10740433; rs12573649; rs7907801; rs1529; rs11000934; rs10824150; rs10740438; rs16931538; rs11001001; rs7081573; rs11817959; rs11000987; rs7907267; rs6480743; rs7906779; rs11819130; rs16931490; rs10824190; rs2169684; rs11001008; rs11000954; rs11000916; rs7894697; rs16931472; rs1189552; rs2126762; rs1052039; rs28433006; rs12767624; rs10709030; rs7476928; rs10699958; rs35967107; rs4328165; rs12256125; rs35681751; rs6480750; rs34148029; rs35946213; rs34428151; rs36030657; rs34269690; rs3037403; rs28806480; rs34213308; rs35291653; rs12265290; rs10587775; rs11001010; rs10400100; rs5786147; rs35242280; rs34546969; rs35683991; rs10618104; rs34215048; rs35938247; rs768959; rs12769918; rs36029311; rs7909834; rs11000950; rs35036011; rs33912244; rs4746184; rs4369336; rs11000973; rs35746333; rs2027266; rs12264178; rs12768982; rs5786138; rs11427369; rs36100829; rs34310248; rs34469098; rs11470196; rs11000993; rs11310691; rs35270154; rs7392652; rs35240931; rs11001076; rs34868542; rs35677795; rs12253997; rs11001024; rs11361618; rs34483117; rs1016419; rs11001062; rs35389691; rs4746213; rs12770163; rs12242773; rs12250065; rs714446; rs7478561; rs11000983; rs35213595; rs35124446; rs12360425; rs11001041; rs7101087; rs12768640; rs34991446; rs11001107; rs34157587; rs34960972; rs11001063; rs6143984; rs11001033; rs10824216; rs7068038; rs11000963; rs12769277; rs12221297; rs34006036; rs35913987; rs35593805; rs11000958; rs35690083; rs12776428; rs12359909; rs35675013; rs34160937; rs17682987; rs11298231; rs28665887; rs34822835; rs10693309; rs12358321; rs11294383; rs35382240; rs11441752; rs11000932; rs3192342; rs10443948; rs34368934; rs16931389; rs4746219; rs7085007; rs16931551; rs12784339; rs34785655; rs35885564; rs34253447; rs34545592; rs35474264; rs35954951; rs12261116; rs1871083; rs4746220; rs12769928; rs35213605; rs34146097; rs11001025; rs1904059; rs35282438; rs34630297; rs35244559; rs36064398; rs12772349; rs35081895; rs10719538; rs12358053; rs12770150; rs10824219; rs4578321; rs11812645; rs11000944; rs11377985; rs9730888; rs11001039; rs35189522; rs11377715; rs10578956; rs12245560; rs11464387; rs11001088; rs1908336; rs2395089; rs11000918; rs7478196; rs11001093; rs35289591; rs35155141; rs10630238; rs11000935; rs11283273; rs11431842; rs11498031; rs12241229; rs12779690; rs35621346; rs35957820; rs11516631; rs35088225; rs28540400; rs35958238; rs3758511; rs11427347; rs35956325; rs11000905; rs12780859; rs34456914; rs12257326; rs11000910; rs2951091; rs11419041; rs35418682; rs35969519; rs34509827; rs34011472; rs11001073; rs13376894; rs16931407; rs11001066; rs3037448; rs34427535; rs12359976; rs11285474; rs28756681; rs34190731; rs11292901; rs34798510; rs12775686; rs7076019; rs12571515; rs35698592; rs10568623; rs7079178; rs35634749; rs35197598; rs11000998; rs34848917; rs7070345; rs35336446; rs35924345; rs34395307; rs35681211; rs34203173; rs7074078; rs11000949; rs12251148; rs11294980; rs34484828; rs7070707; rs5786139; rs35196181; rs7909032; rs34729493; rs34311007; rs35676834; rs34350496; rs35653353; rs35343842; rs35944635; rs34770422; rs35567434; rs11592151; rs34334128; rs4746208; rs12217863; rs12776780; rs10710680; rs34328974; rs11354070; rs35548449; rs35138612; rs11000937; rs5786136; rs34975658; rs11001051; rs5786148; rs12768637; rs12776762; rs11001032; rs35565783; rs35141788; rs5786145; rs34381749; rs34206298; rs16931588; rs11000972; rs34606636; rs35192408; rs11313699; rs11819453; rs12257167; rs35322063; rs34758567; rs11394734; rs4746193; rs34040400; rs12416047; rs7100239; rs35010757; rs11001050; rs35043540; rs35574014; rs35285241; rs12769920; rs11001077; rs35801937; rs9888065; rs12572719; rs12776511; rs11446202; rs11001023; rs4400738; rs34865824; rs3837336; rs12771556; rs35658711; rs11001042; rs9732237; rs34077396; rs12781732; rs12268885; rs16931430; rs34241739; rs11527234; rs11818880; rs12250504; rs12771964; rs4746185; rs11310513; rs7074915; rs35543329; rs7088493; rs34445084; rs12414124; rs10631417; rs35870828; rs35153697; rs12570068; rs2126761; rs11000976; rs12259418; rs35120068; rs34312133; rs4589228; rs34043389; rs34232307; rs11000965; rs34313197; rs12261108; rs12267421; rs35345171; rs12781539; rs1898054; rs34844657; rs12244479; rs11000933; rs12770253; rs1832436; rs35239000; rs4639879; rs35111858; rs11313781; rs12146408; rs7099493; rs36104559; rs12573253; rs12767938; rs34722640; rs35137924; rs35527525; rs35650817; rs34057132; rs34149159; rs11463660; rs11598404; rs2027265; rs41280418; rs34554027; rs12772421; rs11001068; rs11000961; rs10554301; rs11001113; rs10400099; rs35788249; rs11001074; rs11001049; rs35392498; rs11001079; rs11381604; rs34757853; rs11000984; rs10633386; rs28367539; rs35193175; rs5786149; rs36126508; rs11367583; rs34369353; rs12262949; rs35927711; rs949720; rs12769308; rs11001106; rs9733631; rs34985864; rs11527423; rs11289206; rs2894237; rs11320887; rs35035527; rs10596248; rs34829852; rs35566961; rs35148425; rs12259513; rs2395088; rs12777975; rs11001055; rs7078624; rs4746217; rs35385535; rs34440443; rs5786151; rs35822474; rs7478047; rs34684326; rs34778804; rs9731072; rs34447904; rs11458497; rs11361273; rs34029062; rs34301605; rs34969882; rs35062545; rs34668568; rs11596973; rs35067531; rs11000971; rs11000919; rs35038709; rs34848555; rs34943780; rs12775085; rs13376895; rs28550755; rs35630116; rs35480343; rs12358427; rs7476100; rs11001054; rs7916584; rs34117712; rs10646695; rs11001060; rs34025605; rs12782778; rs11000989; rs10550667; rs11001094; rs12254751; rs11001083; rs10592912; rs11001081; rs7914846; rs11001069; rs7083128; rs12771949; rs35844167; rs34807188; rs35351336; rs28798394; rs34628857; rs34464248; rs10653576; rs34498680; rs16931301; rs34644210; rs35318416; rs12357530; rs4506580; rs28886966; rs11527424; rs28711776; rs35836498; rs34575360; rs35138837; rs36106558; rs2894238; rs35333397; rs34945364; rs12261051; rs10546914; rs28705900; rs11000930; rs34022905; rs34369612; rs5786140; rs12415282; rs11001117; rs11451786; rs34788425; rs7476538; rs11000956; rs5786137; rs11000923; rs35465617; rs11001012; rs12355952; rs12267197; rs4303177; rs12254040; rs36070427; rs12770467; rs11000952; rs2027268; rs34323155; rs3037396; rs35856088; rs35278865; rs12357643; rs35046845; rs11434396; rs34777095; rs11597052; rs10667574; rs12763748; rs12414280; rs34427766; rs11498032; rs3037400; rs35287036; rs35285709; rs10710237; rs4746186; rs3037446; rs41405146; rs4746179; rs36119808; rs7072529; rs35194075; rs7094743; rs11300921; rs11000957; rs35630271; rs34844177; rs11597340; rs35918774; rs35774493; rs11599870; rs34794280; rs16931444; rs34535203; rs36041609; rs35654646; rs11357215; rs34600695; rs35167424; rs11000991; rs12764263; rs28620392; rs12765352; rs34417435; rs35499084; rs5786150; rs12771367; rs34006665; rs3957133; rs11000967; rs34878578; rs35302558; rs12255237; rs2395090; rs12098843; rs12220218; rs35091445; rs12251416; rs12764980; rs11598353; rs34605650; rs36016023; rs10693107; rs11596436; rs11000985; rs11492360; rs7100311; rs35008670; rs11001064; rs11000979; rs11001058; rs35705914; rs35798713; rs34320598; rs35102669; rs7090447; rs12261107; rs34385041; rs12267892; rs11593990; rs34053466; rs11312116; rs34287044; rs12767472; rs12359775; rs34820269; rs35056778; rs11000926; rs34396421; rs12355723; rs7083096; rs34992970; rs34064444; rs11000907; rs11001038; rs10578552; rs35152713; rs35733476; rs34480841; rs11001009; rs2395094; rs12775961; rs10558951; rs5786142; rs17744431; rs35872639; rs35658993; rs10535419; rs35203634; rs16931563; rs35781747; rs34577685; rs7082866; rs10527692; rs35945477; rs10565601; rs12248996; rs10657653; rs16931425; rs10612340; rs11000942; rs28673867; rs11001011; rs35803794; rs11000975; rs11380814; rs7093745; rs12782355; rs35927517; rs1140726; rs12262204; rs11000929; rs2027267; rs6480747; rs12247758; rs35796098; rs28457756; rs11000917; rs28599671; rs12767217; rs34601191; rs17746699; rs12098261; rs12255345; rs12250748; rs36073830; rs11297052; rs34377885; rs35708858; rs34454856; rs12241160; rs10669118; rs34336674; rs34920875; rs11001070; rs12415222; rs35421202; rs35759508; rs35249335; rs34947578; rs10400203; rs35521667; rs34161719; rs5786141; rs730660; rs11383205; rs34975150; rs2927517; rs7087005; rs11001021; rs3998213; rs12783210; rs35081179; rs10536957; rs34761801; rs11317030; rs11597174; rs35949478; rs7899397; rs12783738; rs17685047; rs11311986; rs35070470; rs28583797; rs35998695; rs11001095; rs12768800; rs34632561; rs7358249; rs34610545; rs719944; rs10559831; rs34130571; rs34419004; rs34492397; rs35960706; rs11000902; rs16931508; rs12356357; rs35369268; rs35568529; rs11000978; rs11368451; rs7909196; rs11596716; rs11591337; rs10612480; rs10710238; rs35423162; rs36067412; rs35503260; rs11001071; rs35720770; rs4746183; rs35744043; rs12250637; rs4448625; rs4746206; rs12772768; rs11377208; rs12781289; rs34033009; rs34705543; rs12770119; rs12261147; rs11510969; rs35092600; rs35989197; rs34809429; rs11001061; rs28588347; rs11356202; rs4745746; rs12221444; rs34137547; rs10534993; rs12765322; rs34589243; rs28891140; rs35036906; rs5786146; rs7101010; rs35057058; rs12763083; rs12241919; rs35010094; rs35210704; rs11001108; rs1131988; rs12776754; rs12764241; rs11285475; rs35913612; rs12773960; rs11000995; rs11279355; rs34842035; rs11592294; rs12219767; rs35370125; rs35785348; rs34133995; rs12243218; rs34631179; rs12763766; rs34123435; rs12251389; rs35116974; rs35655878; rs35281622; rs35717142; rs35955774; rs12249241; rs34740358; rs12261563; rs11492299; rs12767200; rs34775607; rs34490010; rs36042076; rs11447835; rs35273093; rs11402306; rs11814352; rs11388849; rs12241943; rs28422778; rs10689388; rs11000982; rs11597668; rs35085839; rs11278279; rs34137673; rs11001104; rs11000974; rs11001080; rs34027811; rs5786143; rs35689397; rs7898976; rs35973082; rs11001017; rs35190282; rs34346566; rs12775960; rs12769919; rs12267534; rs12251369; rs7071553; rs10698256; rs34893135; rs28612186; rs35236497; rs28842181; rs35388074; rs11000943; rs7081474; rs34535580; rs12269424; rs10682966; rs10670267; rs11000968; rs34357111; rs34359934; rs11001075; rs16931359; rs12356967; rs35233016; rs11001030; rs12255362; rs11372723; rs4638258; rs4341484; rs16931393; rs11001086; rs11000913; rs12243374; rs4745742; rs34770607; rs12778270; rs34660792; rs11000906; rs11001026; rs28473266; rs4746200; rs7089267; rs12764238; rs11001037; rs12359146; rs3837337; rs1051938; rs1051939; rs10824083; rs10824085; rs10824086; rs11000888; rs11000889; rs11000892; rs11000893; rs11000894; rs11000897; rs11817132; rs1189549; rs1189550; rs1189551; rs12256105; rs12358614; rs12572479; rs12778712; rs1338389; rs1766711; rs1766713; rs17676126; rs1774692; rs1871084; rs1874147; rs1908330; rs2788148; rs2894228; rs3812639; rs3829129; rs4638254; rs4746176; rs6480720; rs7071701; rs7079959; rs7099159; rs733350; rs7896323

# Metabolic_Enzyme_97_General_References:
8577746; 8917457; 9070863; 9843365; 12112843

# Metabolic_Enzyme_97_References:
Not Available

# Metabolic_Enzyme_98_ID:
5715

# Metabolic_Enzyme_98_Name:
Hypoxanthine-guanine phosphoribosyltransferase

# Metabolic_Enzyme_98_Synonyms:
HGPRT; HGPRTase

# Metabolic_Enzyme_98_Gene_Name:
HPRT1

# Metabolic_Enzyme_98_Protein_Sequence:
>Hypoxanthineguanine phosphoribosyltransferase
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA

# Metabolic_Enzyme_98_Number_of_Residues:
218

# Metabolic_Enzyme_98_Molecular_Weight:
24580

# Metabolic_Enzyme_98_Theoretical_pI:
6.67

# Metabolic_Enzyme_98_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
Function:  hypoxanthine phosphoribosyltransferase activity
 ||
>>>
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  purine salvage
Process:  purine ribonucleoside salvage
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_98_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_98_Specific_Function:
IMP + diphosphate = hypoxanthine + 5-phospho- alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_98_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_98_Reaction:
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_98_Pfam_Domain_Function:
PF00156:Pribosyltran

# Metabolic_Enzyme_98_Signals:
None

# Metabolic_Enzyme_98_Transmembrane_Regions:
None

# Metabolic_Enzyme_98_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_98_EC_Link:
EC 2.4.2.8

# Metabolic_Enzyme_98_GenBank_ID_Protein:
306885

# Metabolic_Enzyme_98_SwissProt_ID:
HPRT_HUMAN (P00492)

# Metabolic_Enzyme_98_swissprot_Name:
Not Available

# Metabolic_Enzyme_98_Genecard_id:
HPRT1

# Metabolic_Enzyme_98_Geneatlas_id:
HPRT1

# Metabolic_Enzyme_98_hgnc_id:
HGNC:5157

# Metabolic_Enzyme_98_PDB_ID:
1BZY

# Metabolic_Enzyme_98_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_98_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_98_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_98_Gene_Sequence:
>657 bp
ATGGCGACCCGCAGCCCTGGCGTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGAT
TTATTTTGCATACCTAATCATTATGCTGAGGATTTGGAAAGGGTGTTTATTCCTCATGGA
CTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCAT
CACATTGTAGCCCTCTGTGTGCTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGAT
TACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACTGTAGATTTTATC
AGACTGAAGAGCTATTGTAATGACCAGTCAACAGGGGACATAAAAGTAATTGGTGGAGAT
GATCTCTCAACTTTAACTGGAAAGAATGTCTTGATTGTGGAAGATATAATTGACACTGGC
AAAACAATGCAGACTTTGCTTTCCTTGGTCAGGCAGTATAATCCAAAGATGGTCAAGGTC
GCAAGCTTGCTGGTGAAAAGGACCCCACGAAGTGTTGGATATAAGCCAGACTTTGTTGGA
TTTGAAATTCCAGACAAGTTTGTTGTAGGATATGCCCTTGACTATAATGAATACTTCAGG
GATTTGAATCATGTTTGTGTCATTAGTGAAACTGGAAAAGCAAAATACAAAGCCTAA

# Metabolic_Enzyme_98_GenBank_ID_Gene:
M31642

# Metabolic_Enzyme_98_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_98_Locus:
Xq26.1

# Metabolic_Enzyme_98_SNPs:
rs17882614; rs17324664; rs1468266; rs6638240; rs6638244; rs629; rs12687175; rs2070888; rs17882706; rs17879768; rs6638243; rs6634993; rs2283774; rs2515695; rs17324671; rs17000619; rs17879343; rs17881098; rs17883992; rs17882148; rs6634992; rs17885981; rs17879832; rs17879883; rs17882974; rs17879054; rs6654281; rs17885745; rs17878776; rs17885116; rs17882408; rs17883944; rs17879655; rs17879788; rs17885487; rs17879062; rs12383909; rs17882655; rs6638248; rs17879889; rs6638241; rs17880246; rs17879587; rs12008402; rs17885587; rs17879537; rs17885351; rs17879338; rs17886003; rs17884897; rs17879126; rs17884671; rs17878519; rs17885249; rs17878726; rs17882575; rs630; rs17879579; rs17885481; rs17882577; rs17882724; rs17880173; rs17882449; rs17878366; rs17883719; rs17882059; rs17885063; rs17878341; rs17885117; rs17882713; rs17882954; rs17878494; rs17882387; rs17879006; rs17886404; rs17879389; rs17885867; rs17883942; rs17878843; rs17885455; rs17882760; rs17884775; rs6634990; rs6634995; rs17878582; rs17878883; rs17882358; rs17879110; rs17881011; rs35095771; rs41299094; rs17879494; rs17878772; rs11369747; rs12839009; rs17880167; rs17882944; rs17881023; rs374290; rs35009311; rs17883755; rs12861067; rs17882363; rs34425749; rs34838035; rs366687; rs6638242; rs17879610; rs28478865; rs17887208; rs405630; rs12380958; rs5903878; rs17878547; rs35869442; rs387714; rs35585686; rs6634994; rs17882487; rs17879085; rs5978009; rs5933415; rs17883196; rs116493; rs5933416; rs12836923; rs12381664; rs35238558; rs17882186; rs373901; rs35653185; rs17881003; rs6638245; rs35325865; rs35834777; rs11406107; rs17884978; rs17885259; rs17882884; rs17883708; rs12836918; rs391918; rs34619253; rs377106; rs35538011; rs17884910; rs398712; rs5933414; rs35832135; rs17885490; rs12381784; rs377103; rs5903877; rs17880051; rs12838998; rs17878536; rs11344152; rs2503983; rs36109224; rs17884854; rs17878792; rs17878589; rs7472760; rs28663133; rs117407; rs17881034; rs12381662; rs17886030; rs6638246; rs17885101; rs17879848; rs17879532; rs17882283; rs417522; rs17878403; rs414365; rs5978007; rs398716; rs7357883; rs10482430; rs12689866; rs12847109; rs437849; rs4829768; rs6634997; rs6638238

# Metabolic_Enzyme_98_General_References:
6300847; 2341149; 7107641; 3023844; 8044844; 10360366; 10338013; 1487231; 6853490; 6853716; 6572373; 6706936; 3358423; 3384338; 3265398; 2896620; 3198771; 3148064; 2572141; 2909537; 2910902; 2738157; 2928313; 2347587; 2358296; 2246854; 2018042; 2071157; 1937471; 1840476; 1551676; 1301916; 7627191; 9003484; 9452051

# Metabolic_Enzyme_98_References:
Not Available

# Metabolic_Enzyme_99_ID:
5913

# Metabolic_Enzyme_99_Name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

# Metabolic_Enzyme_99_Synonyms:
GMP-PDE delta; p17 protein

# Metabolic_Enzyme_99_Gene_Name:
PDE6D

# Metabolic_Enzyme_99_Protein_Sequence:
>Retinal rod rhodopsinsensitive cGMP 3',5'cyclic phosphodiesterase subunit delta
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVS
RELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPA
SVLTGNVIIETKFFDDDLLVSTSRVRLFYV

# Metabolic_Enzyme_99_Number_of_Residues:
150

# Metabolic_Enzyme_99_Molecular_Weight:
17420

# Metabolic_Enzyme_99_Theoretical_pI:
5.35

# Metabolic_Enzyme_99_GO_Classification:
Not Available

# Metabolic_Enzyme_99_General_Function:
Not Available

# Metabolic_Enzyme_99_Specific_Function:
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate

# Metabolic_Enzyme_99_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_99_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_99_Pfam_Domain_Function:
PF05351:GMP_PDE_delta

# Metabolic_Enzyme_99_Signals:
None

# Metabolic_Enzyme_99_Transmembrane_Regions:
None

# Metabolic_Enzyme_99_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_99_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_99_GenBank_ID_Protein:
2896020

# Metabolic_Enzyme_99_SwissProt_ID:
PDE6D_HUMAN (O43924)

# Metabolic_Enzyme_99_swissprot_Name:
Not Available

# Metabolic_Enzyme_99_Genecard_id:
PDE6D

# Metabolic_Enzyme_99_Geneatlas_id:
PDE6D

# Metabolic_Enzyme_99_hgnc_id:
HGNC:8788

# Metabolic_Enzyme_99_PDB_ID:
1KSG

# Metabolic_Enzyme_99_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_99_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_99_Subcellular_Location:
Not Available

# Metabolic_Enzyme_99_Gene_Sequence:
>453 bp
ATGTCAGCCAAGGACGAGCGGGCCAGGGAGATCCTGAGGGGCTTCAAACTAAATTGGATG
AACCTTCGGGATGCTGAGACAGGGAAGATACTCTGGCAAGGAACAGAAGACCTGTCTGTC
CCTGGTGTGGAGCATGAAGCCCGTGTTCCCAAGAAAATCCTCAAGTGCAAGGCAGTGTCT
CGAGAACTTAATTTTTCTTCGACAGAACAAATGGAAAAATTCCGCCTGGAACAAAAAGTT
TACTTCAAAGGGCAATGCCTAGAAGAATGGTTCTTCGAGTTTGGCTTTGTGATCCCTAAC
TCCACAAATACCTGGCAGTCCTTGATAGAGGCAGCACCCGAGTCCCAGATGATGCCAGCA
AGCGTCTTAACTGGGAACGTTATCATAGAAACAAAGTTTTTTGACGACGATCTTCTTGTA
AGCACATCCAGAGTGAGACTTTTCTATGTTTGA

# Metabolic_Enzyme_99_GenBank_ID_Gene:
AF045999

# Metabolic_Enzyme_99_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_99_Locus:
2q35-q36

# Metabolic_Enzyme_99_SNPs:
rs8165; rs838447; rs1464974; rs838424; rs2570991; rs838448; rs6719408; rs7564574; rs838421; rs838446; rs6437035; rs6437036; rs4479418; rs1464976; rs865706; rs6727769; rs2340510; rs17271824; rs7564057; rs2693781; rs11682986; rs1055300; rs3912020; rs11691808; rs11886088; rs3748922; rs7578649; rs838459; rs1246073; rs838460; rs17271838; rs1986882; rs4973479; rs6729974; rs1246074; rs838442; rs838443; rs838423; rs4134454; rs4017857; rs838450; rs10208197; rs838445; rs10175192; rs16828383; rs11680005; rs11886978; rs2693782; rs10192111; rs11694559; rs1097849; rs17199642; rs1246072; rs11673810; rs1965569; rs865123; rs12466215; rs13425658; rs11687347; rs1097850; rs1464975; rs1246075; rs10174681; rs13412329; rs16828376; rs16828400; rs6437034; rs3830625; rs12468852; rs28364600; rs13424754; rs838425; rs35244888; rs838418; rs1246076; rs13388804; rs35193628; rs34916848; rs13017826; rs35427226; rs2340509; rs838444; rs35025339; rs11457200; rs2570994; rs34130127; rs3074725; rs34460175; rs1246067; rs6712578; rs866305; rs13392795; rs35343404; rs34916207; rs13020381; rs35633303; rs838420; rs2693778; rs838451; rs13416010; rs35413921; rs7574492; rs10164942; rs838415; rs3038045; rs13385970; rs36126237; rs11685411; rs10933382; rs34007857; rs34039711; rs13405908; rs34036079; rs838414; rs3887889; rs6745121; rs36043938; rs36094785; rs13412333; rs13029089; rs11413975; rs12620711; rs838449; rs12996166; rs1246069; rs2570990; rs34957131; rs36062317; rs34051193; rs35115820; rs955400; rs838417; rs13415801; rs3074722; rs13005798; rs1246068; rs34278996; rs34172773; rs838452; rs33924844; rs838416; rs7606479; rs12613234; rs838422; rs9973802; rs10168868; rs13020414; rs36006197; rs35042825; rs35145561; rs34036232; rs13417992; rs11679847; rs34089848; rs838419; rs13392965; rs13392413; rs838426; rs3210343; rs28642731; rs7607294; rs3210342; rs34031981; rs11557625; rs11682745; rs11689891; rs13392019; rs1554731; rs16825960; rs16828434; rs17199663; rs17271845; rs3748921; rs6437033; rs6732581; rs7598298; rs838427; rs838428; rs838429; rs838432

# Metabolic_Enzyme_99_General_References:
9570951; 9533031; 9781033; 10518933; 11980706

# Metabolic_Enzyme_99_References:
Not Available

# Metabolic_Enzyme_100_ID:
5271

# Metabolic_Enzyme_100_Name:
Acetyl-coenzyme A synthetase 2-like, mitochondrial precursor

# Metabolic_Enzyme_100_Synonyms:
Acetate--CoA ligase 2; Acetyl-CoA synthetase 2; Acyl- CoA synthetase short-chain family member 1

# Metabolic_Enzyme_100_Gene_Name:
ACSS1

# Metabolic_Enzyme_100_Protein_Sequence:
>Acetylcoenzyme A synthetase 2like, mitochondrial precursor
MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPGSYPA
LSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVR
KSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVA
AMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVK
HCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGM
PKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLF
ESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPI
NCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVL
MDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEG
GYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKD
SAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELG
DTTTLEDPSIIAEILSVYQKCKDKQAAAK

# Metabolic_Enzyme_100_Number_of_Residues:
689

# Metabolic_Enzyme_100_Molecular_Weight:
74857

# Metabolic_Enzyme_100_Theoretical_pI:
7.11

# Metabolic_Enzyme_100_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  AMP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-sulfur bonds
Function:  CoA-ligase activity
Function:  acetate-CoA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_100_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_100_Specific_Function:
Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2)

# Metabolic_Enzyme_100_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_100_Reaction:
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

# Metabolic_Enzyme_100_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_100_Signals:
1-22

# Metabolic_Enzyme_100_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_100_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_100_EC_Link:
EC 6.2.1.1

# Metabolic_Enzyme_100_GenBank_ID_Protein:
56203089

# Metabolic_Enzyme_100_SwissProt_ID:
ACS2L_HUMAN (Q9NUB1)

# Metabolic_Enzyme_100_swissprot_Name:
Not Available

# Metabolic_Enzyme_100_Genecard_id:
ACSS1

# Metabolic_Enzyme_100_Geneatlas_id:
ACSS1

# Metabolic_Enzyme_100_hgnc_id:
HGNC:16091

# Metabolic_Enzyme_100_PDB_ID:
Not Available

# Metabolic_Enzyme_100_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_100_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_100_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_100_Gene_Sequence:
>1439 bp
CCAAGTGCAAGGTGGTTATCACCTTCAACCAAGGACTCCGGGGTGGGCGCGTGGTGGAGC
TGAAGAAAATAGTGGATGAGGCTGTGAAGCACTGCCCCACCGTGCAGCATGTCCTGGTGG
CTCACAGGACAGACAACAAGGTCCACATGGGGGATCTGGACGTCCCGCTGGAGCAGGAAA
TGGCCAAGGAGGACCCTGTTTGCGCCCCAGAGAGCATGGGCAGTGAGGACATGCTCTTCA
TGCTGTACACCTCAGGGAGCACCGGAATGCCCAAGGGCATCGTCCATACCCAGGCAGGCT
ACCTGCTCTATGCCGCCCTGACTCACAAGCTTGTGTTTGACCACCAGCCAGGTGACATCT
TTGGCTGTGTGGCCGACATCGGTTGGATTACAGGACACAGCTACGTGGTGTATGGGCCTC
TCTGCAATGGTGCCACCAGCGTCCTTTTTGAGAGCACCCCAGTTTATCCCAATGCTGGTC
GGTACTGGGAGACAGTAGAGAGGTTGAAGATCAATCAGTTCTATGGCGCCCCAACGGCTG
TCCGGCTGTTGCTGAAATACGGTGATGCCTGGGTGAAGAAGTATGATCGCTCCTCCCTGC
GGACCCTGGGGTCAGTGGGAGAGCCCATCAACTGTGAGGCCTGGGAGTGGCTTCACAGGG
TGGTGGGGGACAGCAGGTGCACGCTGGTGGACACCTGGTGGCAGACAGAAACAGGTGGCA
TCTGCATCGCACCACGGCCCTCGGAAGAAGGGGCGGAAATCCTCCCTGCCATGGCGATGA
GGCCCTTCTTTGGCATCGTCCCCGTCCTCATGGATGAGAAGGGCAGCGTCGTGGAGGGCA
GCAACGTCTCCGGGGCCCTGTGCATCTCCCAGGCCTGGCCGGGCATGGCCAGGACCATCT
ATGGCGACCACCAGCGATTTGTGGACGCCTACTTCAAGGCCTACCCAGGCTATTACTTCA
CTGGAGACGGGGCTTACCGAACTGAGGGCGGCTATTACCAGATCACAGGGCGGATGGATG
ATGTCATCAACATCAGTGGCCACCGGCTGGGGACCGCAGAGATTGAGGACGCCATCGCCG
ACCACCCTGCAGTACCAGAAAGTGCTGTCATTGGCTACCCCCACGACATCAAAGGAGAAG
CTGCCTTTGCCTTCATTGTGGTGAAAGATAGTGCGGGTGACTCAGATGTGGTGGTGCAGG
AGCTCAAGTCCATGGTGGCCACCAAGATCGCCAAATATGCTGTGCCTGATGAGATCCTGG
TGGTGAAACGTCTTCCAAAAACCAGGTCTGGGAAGGTCATGCGGCGGCTCCTGAGGAAGA
TCATCACTAGTGAGGCCCAGGAGCTGGGAGACACTACCACCTTGGAGGACCCCAGCATCA
TCGCAGAGATCCTGAGTGTCTACCAGAAGTGCAAGGACAAGCAGGCTGCTGCTAAGTGA

# Metabolic_Enzyme_100_GenBank_ID_Gene:
AL035661

# Metabolic_Enzyme_100_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_100_Locus:
20p11.23-p11.21

# Metabolic_Enzyme_100_SNPs:
rs6050249; rs6115003; rs6050259; rs6115001; rs3746331; rs6114999; rs6132784; rs6083718; rs2294980; rs3646; rs3746332; rs8118803; rs6050261; rs6050266; rs7270236; rs6132785; rs11697253; rs11699487; rs6050255; rs8114108; rs910526; rs1007881; rs6138466; rs6115000; rs6083728; rs11908104; rs3746330; rs6050281; rs6138473; rs6050267; rs8124799; rs6115002; rs6115010; rs910527; rs4815363; rs6132792; rs11908037; rs6083725; rs761720; rs6050252; rs7263112; rs6132789; rs6115015; rs2144371; rs2179732; rs4815364; rs6106989; rs8121327; rs4815361; rs6050268; rs11698964; rs6083726; rs6037010; rs7271250; rs6076312; rs1015278; rs6138478; rs1985485; rs6037007; rs6515575; rs11699824; rs11907003; rs6050263; rs6106986; rs12624595; rs6138475; rs6050262; rs6083729; rs6083727; rs7273310; rs6050270; rs11907817; rs6138470; rs8119255; rs12481389; rs7268879; rs6138474; rs7273518; rs6050257; rs6115011; rs6083730; rs4813543; rs4392331; rs6115009; rs6115008; rs7265897; rs13039383; rs1960190; rs11698942; rs6115013; rs6050264; rs11907559; rs7262168; rs7266133; rs6106985; rs6050253; rs12480685; rs6037013; rs1555157; rs1555158; rs7273872; rs6138465; rs6138464; rs7268196; rs6114995; rs3928737; rs6050244; rs7273998; rs6037006; rs6114996; rs6114997; rs6050290; rs1973921; rs9967918; rs6083719; rs41308619; rs6050250; rs41315096; rs34418920; rs7265950; rs6050247; rs8118553; rs6050245; rs6050246; rs6050248; rs11349463; rs6114998; rs3746333; rs11556305; rs6138480; rs6037009; rs2024740; rs6083720; rs6050282; rs34106051; rs34040475; rs6138467; rs7265967; rs35754748; rs6106987; rs7347286; rs7268641; rs35918514; rs5841047; rs6050285; rs11908357; rs6132786; rs10667081; rs6050273; rs6050288; rs35440489; rs11475510; rs11087496; rs6050283; rs2235848; rs6083721; rs41315094; rs5841046; rs35370044; rs6132788; rs6050258; rs35022349; rs6132787; rs36083645; rs6037011; rs34821066; rs6138479; rs33974103; rs34478164; rs6138481; rs6083731; rs6115018; rs7363000; rs6138472; rs6050286; rs35714586; rs6115014; rs6083723; rs6050265; rs8123929; rs35559944; rs34768826; rs6050275; rs35187537; rs6132793; rs34248454; rs4813544; rs6050269; rs6115012; rs33947143; rs6083724; rs34068044; rs34114131; rs34202442; rs6050272; rs35419604; rs11474894; rs34478614; rs7272596; rs34772607; rs11696684; rs6132791; rs3086647; rs6106990; rs6138471; rs11469635; rs7265721; rs10701711; rs11699715; rs6050271; rs35841792; rs6050251; rs8114568; rs34766073; rs34911154; rs6050284; rs34012555; rs35888097; rs6132790; rs11472149; rs8123923; rs34740612; rs36081306; rs7270177; rs8182893; rs6037008; rs11473680; rs6050287; rs11480696; rs6138476; rs6050274; rs34340531; rs4815365; rs8184324; rs33955639; rs5841045; rs11482316; rs6050289; rs35994199; rs7271571; rs1005409; rs11905625; rs11905675; rs2207631; rs2387573; rs2387577; rs4239751; rs6050243; rs6050291; rs6083712; rs6083713; rs6083714; rs6114987; rs6114991; rs6138461; rs6138462; rs7274899

# Metabolic_Enzyme_100_General_References:
11780052; 11347906; 12168954

# Metabolic_Enzyme_100_References:
Not Available

# Metabolic_Enzyme_101_ID:
5914

# Metabolic_Enzyme_101_Name:
Probable histidyl-tRNA synthetase, mitochondrial precursor

# Metabolic_Enzyme_101_Synonyms:
Histidine--tRNA ligase; HisRS; Histidine--tRNA ligase-like

# Metabolic_Enzyme_101_Gene_Name:
HARSL

# Metabolic_Enzyme_101_Protein_Sequence:
>Probable histidyltRNA synthetase, mitochondrial precursor
MPLLGLLPRRAWASLLSQLLRPPCASCTGAVRCQSQVAEAVLTSQLKAHQEKPNFIIKTP
KGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGLMYDLKD
QGGELLSLRYDLTVPFARYLAMNKVKKMKRYHVGKVWRRESPTIVQGRYREFCQCDFDIA
GQFDPMIPDAECLKIMCEILSGLQLGDFLIKVNDRRIVDGMFAVCGVPESKFRAICSSID
KLDKMAWKDVRHEMVVKKGLAPEVADRIGDYVQCHGGVSLVEQMFQDPRLSQNKQALEGL
GDLKLLFEYLTLFGIADKISFDLSLARGLDYYTGVIYEAVLLQTPTQAGEEPLNVGSVAA
GGRYDGLVGMFDPKGHKVPCVGLSIGVERIFYIVEQRMKTKGEKVRTTETQVFVATPQKN
FLQERLKLIAELWDSGIKAEMLYKNNPKLLTQLHYCESTGIPLVVIIGEQELKEGVIKIR
SVASREEVAIKRENFVAEIQKRLSES

# Metabolic_Enzyme_101_Number_of_Residues:
506

# Metabolic_Enzyme_101_Molecular_Weight:
56889

# Metabolic_Enzyme_101_Theoretical_pI:
8.35

# Metabolic_Enzyme_101_GO_Classification:
>>>
Function:  histidine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  histidyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  protein biosynthesis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_101_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_101_Specific_Function:
ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)

# Metabolic_Enzyme_101_Pathway:
map00340  Histidine metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_101_Reaction:
ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)

# Metabolic_Enzyme_101_Pfam_Domain_Function:
PF03129:HGTP_anticodon;
PF00587:tRNA-synt_2b

# Metabolic_Enzyme_101_Signals:
1-13

# Metabolic_Enzyme_101_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_101_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_101_EC_Link:
EC 6.1.1.21

# Metabolic_Enzyme_101_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_101_SwissProt_ID:
SYHM_HUMAN (P49590)

# Metabolic_Enzyme_101_swissprot_Name:
Not Available

# Metabolic_Enzyme_101_Genecard_id:
HARSL

# Metabolic_Enzyme_101_Geneatlas_id:
HARSL

# Metabolic_Enzyme_101_hgnc_id:
HGNC:4817

# Metabolic_Enzyme_101_PDB_ID:
Not Available

# Metabolic_Enzyme_101_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_101_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_101_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_101_Gene_Sequence:
Not Available

# Metabolic_Enzyme_101_GenBank_ID_Gene:
U18936

# Metabolic_Enzyme_101_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_101_Locus:
5q31.3

# Metabolic_Enzyme_101_SNPs:
Not Available

# Metabolic_Enzyme_101_General_References:
7755634

# Metabolic_Enzyme_101_References:
Not Available

# Metabolic_Enzyme_102_ID:
5399

# Metabolic_Enzyme_102_Name:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 precursor

# Metabolic_Enzyme_102_Synonyms:
E-NPP 2; Extracellular lysophospholipase D; LysoPLD; Autotaxin

# Metabolic_Enzyme_102_Gene_Name:
ENPP2

# Metabolic_Enzyme_102_Protein_Sequence:
>Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 precursor
MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCK
GRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHC
SEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDA
TFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHER
PSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDH
GMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQH
FKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNK
VNSMQTVFVGYGPTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTF
RPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEERHLLYG
RPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVS
PSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVL
VKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQ
PADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFR
KTSRSYPEILTLKTYLHTYESEI

# Metabolic_Enzyme_102_Number_of_Residues:
863

# Metabolic_Enzyme_102_Molecular_Weight:
99004

# Metabolic_Enzyme_102_Theoretical_pI:
7.39

# Metabolic_Enzyme_102_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  nuclease activity
Function:  endonuclease activity
Function:  binding
Function:  nucleic acid binding
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_102_General_Function:
Not Available

# Metabolic_Enzyme_102_Specific_Function:
Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility- related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development Tumor cell motility-stimulating factor

# Metabolic_Enzyme_102_Pathway:
Not Available

# Metabolic_Enzyme_102_Reaction:
1-alkyl-sn-glycero-3-phosphoethanolamine + H2O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine

# Metabolic_Enzyme_102_Pfam_Domain_Function:
PF01223:Endonuclease_NS;
PF01663:Phosphodiest;
PF01033:Somatomedin_B

# Metabolic_Enzyme_102_Signals:
1-27

# Metabolic_Enzyme_102_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_102_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_102_EC_Link:
EC 3.1.4.39

# Metabolic_Enzyme_102_GenBank_ID_Protein:
537906

# Metabolic_Enzyme_102_SwissProt_ID:
ENPP2_HUMAN (Q13822)

# Metabolic_Enzyme_102_swissprot_Name:
Not Available

# Metabolic_Enzyme_102_Genecard_id:
ENPP2

# Metabolic_Enzyme_102_Geneatlas_id:
ENPP2

# Metabolic_Enzyme_102_hgnc_id:
HGNC:3357

# Metabolic_Enzyme_102_PDB_ID:
Not Available

# Metabolic_Enzyme_102_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_102_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_102_Subcellular_Location:
Secreted protein. Note=Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells

# Metabolic_Enzyme_102_Gene_Sequence:
>2748 bp
ATGGCAAGGAGGAGCTCGTTCCAGTCGTGTCAGATAATATCCCTGTTCACTTTTGCCGTT
GGAGTCAGTATCTGCTTAGGATTCACTGCACATCGAATTAAGAGAGCAGAAGGATGGGAG
GAAGGTCCTCCTACAGTGCTATCAGACTCCCCCTGGACCAACATCTCCGGATCTTGCAAG
GGCAGGTGCTTTGAACTTCAAGAGGCTGGACCTCCTGATTGTCGCTGTGACAACTTGTGT
AAGAGCTATACCAGTTGCTGCCATGACTTTGATGAGCTGTGTTTGAAGACAGCCCGTGGC
TGGGAGTGTACTAAGGACAGATGTGGAGAAGTCAGAAATGAAGAAAATGCCTGTCACTGC
TCAGAGGACTGCTTGGCCAGGGGAGACTGCTGTACCAATTACCAAGTGGTTTGCAAAGGA
GAGTCGCATTGGGTTGATGATGACTGTGAGGAAATAAAGGCCGCAGAATGCCCTGCAGGG
TTTGTTCGCCCTCCATTAATCATCTTCTCCGTGGATGGCTTCCGTGCATCATACATGAAG
AAAGGCAGCAAAGTCATGCCTAATATTGAAAAACTAAGGTCTTGTGGCACACACTCTCCC
TACATGAGGCCGGTGTACCCAACTAAAACCTTTCCTAACTTATACACTTTGGCCACTGGG
CTATATCCAGAATCACATGGAATTGTTGGCAATTCAATGTATGATCCTGTATTTGATGCC
ACTTTTCATCTGCGAGGGCGAGAGAAATTTAATCATAGATGGTGGGGAGGTCAACCGCTA
TGGATTACAGCCACCAAGCAAGGGGTGAAAGCTGGAACATTCTTTTGGTCTGTTGTCATC
CCTCACGAGCGGAGAATATTAACCATATTGCGGTGGCTCACCCTGCCAGATCATGAGAGG
CCTTCGGTCTATGCCTTCTATTCTGAGCAACCTGATTTCTCTGGACACAAATATGGCCCT
TTCGGCCCTGAGGAGAGTAGTTATGGCTCACCTTTTACTCCGGCTAAGAGACCTAAGAGG
AAAGTTGCCCCTAAGAGGAGACAGGAAAGACCAGTTGCTCCTCCAAAGAAAAGAAGAAGA
AAAATACATAGGATGGATCATTATGCTGCGGAAACTCGTCAGGACAAAATGACAAATCCT
CTGAGGGAAATCGACAAAATTGTGGGGCAATTAATGGATGGACTGAAACAACTAAAACTG
CGTCGGTGTGTCAACGTCATCTTTGTCGGAGACCATGGAATGGAAGATGTCACATGTGAT
AGAACTGAGTTCTTGAGTAATTACCTAACTAATGTGGATGATATTACTTTAGTGCCTGGA
ACTCTAGGAAGAATTCGATCCAAATTTAGCAACAATGCTAAATATGACCCCAAAGCCATT
ATTGCCAATCTCACGTGTAAAAAACCAGATCAGCACTTTAAGCCTTACTTGAAACAGCAC
CTTCCCAAACGTTTGCACTATGCCAACAACAGAAGAATTGAGGATATCCATTTATTGGTG
GAACGCAGATGGCATGTTGCAAGGAAACCTTTGGATGTTTATAAGAAACCATCAGGAAAA
TGCTTTTTCCAGGGAGACCACGGATTTGATAACAAGGTCAACAGCATGCAGACTGTTTTT
GTAGGTTATGGCCCAACATTTAAGTACAAGACTAAAGTGCCTCCATTTGAAAACATTGAA
CTTTACAATGTTATGTGTGATCTCCTGGGATTGAAGCCAGCTCCTAATAATGGGACCCAT
GGAAGTTTGAATCATCTCCTGCGCACTAATACCTTCAGGCCAACCATGCCAGAGGAAGTT
ACCAGACCCAATTATCCAGGGATTATGTACCTTCAGTCTGATTTTGACCTGGGCTGCACT
TGTGATGATAAGGTAGAGCCAAAGAACAAGTTGGATGAACTCAACAAACGGCTTCATACA
AAAGGGTCTACAGAAGAGAGACACCTCCTCTATGGGCGACCTGCAGTGCTTTATCGGACT
AGATATGATATCTTATATCACACTGACTTTGAAAGTGGTTATAGTGAAATATTCCTAATG
CTACTCTGGACATCATATACTGTTTCCAAACAGGCTGAGGTTTCCAGCGTTCCTGACCAT
CTGACCAGTTGCGTCCGGCCTGATGTCCGTGTTTCTCCGAGTTTCAGTCAGAACTGTTTG
GCCTACAAAAATGATAAGCAGATGTCCTACGGATTCCTCTTTCCTCCTTATCTGAGCTCT
TCACCAGAGGCTAAATATGATGCATTCCTTGTAACCAATATGGTTCCAATGTATCCTGCT
TTCAAACGGGTCTGGAATTATTTCCAAAGGGTATTGGTGAAGAAATATGCTTCGGAAAGA
AATGGAGTTAACGTGATAAGTGGACCAATCTTCGACTATGACTATGATGGCTTACATGAC
ACAGAAGACAAAATAAAACAGTACGTGGAAGGCAGTTCCATTCCTGTTCCAACTCACTAC
TACAGCATCATCACCAGCTGTCTGGATTTCACTCAGCCTGCCGACAAGTGTGACGGCCCT
CTCTCTGTGTCCTCCTTCATCCTGCCTCACCGGCCTGACAACGAGGAGAGCTGCAATAGC
TCAGAGGACGAATCAAAATGGGTAGAAGAACTCATGAAGATGCACACAGCTAGGGTGCGT
GACATTGAACATCTCACCAGCCTGGACTTCTTCCGAAAGACCAGCCGCAGCTACCCAGAA
ATCCTGACACTCAAGACATACCTGCATACATATGAGAGCGAGATTTAA

# Metabolic_Enzyme_102_GenBank_ID_Gene:
L35594

# Metabolic_Enzyme_102_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_102_Locus:
8q24.1

# Metabolic_Enzyme_102_SNPs:
rs2289886; rs16892767; rs10283100; rs2305129; rs1058913; rs4871364; rs11985985; rs1374099; rs965670; rs745383; rs1374101; rs976423; rs2289889; rs2289888; rs2289885; rs2249015; rs755175; rs2305126; rs6986760; rs6469834; rs7012314; rs6469836; rs3793375; rs2305127; rs714607; rs7464710; rs7017581; rs11778951; rs7822457; rs10808504; rs10097147; rs11782782; rs7007302; rs7002854; rs6469833; rs6989212; rs6987232; rs4304355; rs7842699; rs4871360; rs6982484; rs4871420; rs6982863; rs4520196; rs2875905; rs2305125; rs989569; rs11786983; rs6469835; rs2289887; rs6987751; rs3793378; rs6986021; rs4404943; rs6987103; rs16892849; rs7001006; rs11784229; rs2305128; rs7842627; rs16892786; rs10505369; rs9297599; rs4871419; rs16892742; rs13277188; rs7813069; rs1374100; rs16892826; rs2243749; rs16892741; rs10505367; rs7008865; rs16892902; rs2326304; rs16892872; rs10098410; rs17194431; rs4871401; rs7007970; rs3793376; rs11775668; rs16892820; rs10505366; rs6988706; rs17803228; rs12676315; rs11775064; rs16892900; rs16892852; rs16892887; rs10112316; rs3816330; rs11776051; rs7823511; rs7341607; rs10505368; rs16892827; rs12678907; rs7832704; rs16892751; rs921044; rs17801314; rs1992721; rs16892771; rs2875906; rs12545361; rs16892790; rs2326306; rs16892846; rs10110878; rs16892773; rs16892758; rs16892862; rs16892856; rs11991811; rs3765048; rs10097368; rs7014683; rs7012371; rs7824058; rs965669; rs16892746; rs12544233; rs16892855; rs4870862; rs16892839; rs7837894; rs16892869; rs16892860; rs9297600; rs16892858; rs7012253; rs13249947; rs17192692; rs16892861; rs2326303; rs10097501; rs16892873; rs16892761; rs16892739; rs935360; rs16892821; rs16892807; rs6996637; rs17195493; rs6996969; rs16892857; rs11783720; rs3793377; rs2875904; rs16892899; rs16892776; rs930605; rs16892789; rs16892753; rs16892841; rs16892745; rs935359; rs7823839; rs4871352; rs10505370; rs1803184; rs1058906; rs16892735; rs11553603; rs12114595; rs34702922; rs33924986; rs11453074; rs28668309; rs34146810; rs7007883; rs11385263; rs34550309; rs3086095; rs10651155; rs13252721; rs35384858; rs13276243; rs36111215; rs34238300; rs35324801; rs35114182; rs35211061; rs28545338; rs11330516; rs35914708; rs10651072; rs35785012; rs34251243; rs13276659; rs12114608; rs2164020; rs36112518; rs13263113; rs33994893; rs35227070; rs3838711; rs33956494; rs36108971; rs2326305; rs5894487; rs34087519; rs34647615; rs33962227; rs1865292; rs35332847; rs36157726; rs35136821; rs5894486; rs34846612; rs11385264; rs35287985; rs35074738; rs11453075; rs34149540; rs35057967; rs5894490; rs6988878; rs34069990; rs11779231; rs11314064; rs12678024; rs16892865; rs3765047; rs13252311; rs12114603; rs12680671; rs35328333; rs34249912; rs28719904; rs11994348; rs13252720; rs12386860; rs34044773; rs36023475; rs34746070; rs4871386; rs10602946; rs5894485; rs28424130; rs5024451; rs28627521; rs34894575; rs34497035; rs13265442; rs12114895; rs35853660; rs36108877; rs11424718; rs35516242; rs11784273; rs33940123; rs35601421; rs35132277; rs12114601; rs3217556; rs5894491; rs34469483; rs13266547; rs28401282; rs34795457; rs34309572; rs11474049; rs35694268; rs28430495; rs35109858; rs35459102; rs3835102; rs28528985; rs34900958; rs28687495; rs10110618; rs35805857; rs35384459; rs34294314; rs34078353; rs10660917; rs7829304; rs34745934; rs28500566; rs12114602; rs34896929; rs11300090; rs33942871; rs34042284; rs6986623; rs35656304; rs41408746; rs41524345; rs13281228; rs1529780; rs1529781; rs16892878; rs16892912; rs17215053; rs2028849; rs6469837; rs7008680; rs7839329; rs7840386; rs965301; rs994392

# Metabolic_Enzyme_102_General_References:
7982964; 8579579; 8586446

# Metabolic_Enzyme_102_References:
Not Available

# Metabolic_Enzyme_103_ID:
5915

# Metabolic_Enzyme_103_Name:
Ubiquitin-conjugating enzyme E2 J1

# Metabolic_Enzyme_103_Synonyms:
Non-canonical ubiquitin-conjugating enzyme 1; NCUBE1; Yeast ubiquitin-conjugating enzyme UBC6 homolog E; HSUBC6e

# Metabolic_Enzyme_103_Gene_Name:
UBE2J1

# Metabolic_Enzyme_103_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 J1
METRYNLKSPAVKRLMKEAAELKDPTDHYHAQPLEDNLFEWHFTVRGPPDSDFDGGVYHG
RIVLPPEYPMKPPSIILLTANGRFEVGKKICLSISGHHPETWQPSWSIRTALLAIIGFMP
TKGEGAIGSLDYTPEERRALAKKSQDFCCEGCGSAMKDVLLPLKSGSDSSQADQEAKELA
RQISFKAEVNSSGKTISESDLNHSFSLTDLQDDIPTTFQGATASTSYGLQNSSAASFHQP
TQPVAKNTSMSPRQRRAQQQSQRRLSTSPDVIQGHQPRDNHTDHGGSAVLIVILTLALAA
LIFRRIYLANEYIFDFEL

# Metabolic_Enzyme_103_Number_of_Residues:
318

# Metabolic_Enzyme_103_Molecular_Weight:
35199

# Metabolic_Enzyme_103_Theoretical_pI:
6.74

# Metabolic_Enzyme_103_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_103_General_Function:
Not Available

# Metabolic_Enzyme_103_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum

# Metabolic_Enzyme_103_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_103_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_103_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_103_Signals:
None

# Metabolic_Enzyme_103_Transmembrane_Regions:
283-303

# Metabolic_Enzyme_103_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_103_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_103_GenBank_ID_Protein:
7362973

# Metabolic_Enzyme_103_SwissProt_ID:
UB2J1_HUMAN (Q9Y385)

# Metabolic_Enzyme_103_swissprot_Name:
Not Available

# Metabolic_Enzyme_103_Genecard_id:
UBE2J1

# Metabolic_Enzyme_103_Geneatlas_id:
UBE2J1

# Metabolic_Enzyme_103_hgnc_id:
HGNC:17598

# Metabolic_Enzyme_103_PDB_ID:
Not Available

# Metabolic_Enzyme_103_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_103_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_103_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass type IV membrane protein

# Metabolic_Enzyme_103_Gene_Sequence:
>957 bp
ATGGAGACCCGCTACAACCTGAAGAGTCCGGCTGTTAAACGTTTAATGAAAGAAGCGGCA
GAATTGAAAGATCCAACAGATCATTACCATGCGCAGCCTTTAGAGGATAACCTTTTTGAA
TGGCACTTCACGGTTAGAGGGCCCCCAGACTCCGATTTTGATGGAGGAGTTTATCACGGG
CGGATAGTACTGCCACCAGAGTATCCCATGAAACCACCAAGCATTATTCTCCTAACGGCT
AATGGTCGATTTGAAGTGGGCAAGAAAATCTGTTTGAGCATCTCAGGCCATCATCCTGAA
ACTTGGCAGCCTTCGTGGAGTATAAGGACAGCATTATTAGCCATCATTGGGTTTATGCCA
ACAAAAGGAGAGGGAGCCATAGGTTCTCTAGATTACACTCCTGAGGAAAGAAGAGCACTT
GCCAAAAAATCACAAGATTTCTGTTGTGAAGGATGTGGCTCTGCCATGAAGGATGTCCTG
TTGCCTTTAAAATCTGGAAGCGATTCAAGCCAAGCTGACCAAGAAGCCAAAGAACTGGCT
AGGCAAATAAGCTTTAAGGCAGAAGTCAATTCATCTGGAAAGACTATCTCTGAGTCAGAC
TTAAACCACTCTTTTTCACTAACTGATTTACAAGATGATATACCTACAACATTCCAGGGT
GCTACGGCCAGTACATCGTACGGACTCCAGAATTCCTCAGCAGCATCCTTTCATCAACCT
ACCCAACCTGTAGCTAAGAATACCTCCATGAGCCCTCGACAGCGCCGGGCCCAGCAGCAG
AGTCAGAGAAGGTTGTCTACTTCACCAGATGTAATCCAGGGCCACCAGCCAAGAGACAAC
CACACTGATCATGGTGGGTCAGCTGTACTGATTGTCATCCTGACTTTGGCATTGGCAGCT
CTTATATTCCGACGAATATATCTGGCAAACGAATACATATTTGACTTTGAGTTATAA

# Metabolic_Enzyme_103_GenBank_ID_Gene:
AJ245898

# Metabolic_Enzyme_103_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_103_Locus:
6q15

# Metabolic_Enzyme_103_SNPs:
Not Available

# Metabolic_Enzyme_103_General_References:
10708578; 12082160; 10810093; 11042152; 14574404

# Metabolic_Enzyme_103_References:
Not Available

# Metabolic_Enzyme_104_ID:
5916

# Metabolic_Enzyme_104_Name:
Long-chain-fatty-acid--CoA ligase 5

# Metabolic_Enzyme_104_Synonyms:
Long-chain acyl-CoA synthetase 5; LACS 5

# Metabolic_Enzyme_104_Gene_Name:
ACSL5

# Metabolic_Enzyme_104_Protein_Sequence:
>LongchainfattyacidCoA ligase 5
MLFIFNFLFSPLPTPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIEGGARKGVS
QKNNDLTSCCFSDAKTMYEVFQRGLAVSDNGPCLGYRKPNQPYRWLSYKQVSDRAEYLGS
CLLHKGYKSSPDQFVGIFAQNRPEWIISELACYTYSMVAVPLYDTLGPEAIVHIVNKADI
AMVICDTPQKALVLIGNVEKGFTPSLKVIILMDPFDDDLKQRGEKSGIEILSLYDAENLG
KEHFRKPVPPSPEDLSVICFTSGTTGDPKGAMITHQNIVSNAAAFLKCVEHAYEPTPDDV
AISYLPLAHMFERIVQAVVYSCGARVGFFQGDIRLLADDMKTLKPTLFPAVPRLLNRIYD
KVQNEAKTPLKKFLLKLAVSSKFKELQKGIIRHDSFWDKLIFAKIQDSLGGRVRVIVTGA
APMSTSVMTFFRAAMGCQVYEAYGQTECTGGCTFTLPGDWTSGHVGVPLACNYVKLEDVA
DMNYFTVNNEGEVCIKGTNVFKGYLKDPEKTQEALDSDGWLHTGDIGRWLPNGTLKIIDR
KKNIFKLAQGEYIAPEKIENIYNRSQPVLQIFVHGESLRSSLVGVVVPDTDVLPSFAAKL
GVKGSFEELCQNQVVREAILEDLQKIGKESGLKTFEQVKAIFLHPEPFSIENGLLTPTLK
AKRGELSKYFRTQIDSLYEHIQD

# Metabolic_Enzyme_104_Number_of_Residues:
683

# Metabolic_Enzyme_104_Molecular_Weight:
75992

# Metabolic_Enzyme_104_Theoretical_pI:
6.91

# Metabolic_Enzyme_104_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_104_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_104_Specific_Function:
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids

# Metabolic_Enzyme_104_Pathway:
map00071  Fatty acid metabolism

# Metabolic_Enzyme_104_Reaction:
ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

# Metabolic_Enzyme_104_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_104_Signals:
1-35

# Metabolic_Enzyme_104_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_104_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_104_EC_Link:
EC 6.2.1.3

# Metabolic_Enzyme_104_GenBank_ID_Protein:
6174680

# Metabolic_Enzyme_104_SwissProt_ID:
ACSL5_HUMAN (Q9ULC5)

# Metabolic_Enzyme_104_swissprot_Name:
Not Available

# Metabolic_Enzyme_104_Genecard_id:
ACSL5

# Metabolic_Enzyme_104_Geneatlas_id:
ACSL5

# Metabolic_Enzyme_104_hgnc_id:
HGNC:16526

# Metabolic_Enzyme_104_PDB_ID:
Not Available

# Metabolic_Enzyme_104_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_104_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_104_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type III membrane protein. Peroxisome; peroxisomal membrane; single-pass type III membrane protein (By similarity). Microsome; microsomal membrane; single-pass type III membrane protein (By similarity)

# Metabolic_Enzyme_104_Gene_Sequence:
>2052 bp
ATGCTTTTTATCTTTAACTTTTTGTTTTCCCCACTTCCGACCCCGGCGTTGATCTGCATC
CTGACATTTGGAGCTGCCATCTTCTTGTGGCTGATCACCAGACCTCAACCCGTCTTACCT
CTTCTTGACCTGAACAATCAGTCTGTGGGAATTGAGGGAGGAGCACGGAAGGGGGTTTCC
CAGAAGAACAATGACCTAACAAGTTGCTGCTTCTCAGATGCCAAGACTATGTATGAGGTT
TTCCAAAGAGGACTCGCTGTGTCTGACAATGGGCCCTGCTTGGGATATAGAAAACCAAAC
CAGCCCTACAGATGGCTATCTTACAAACAGGTGTCTGATAGAGCAGAGTACCTGGGTTCC
TGTCTCTTGCATAAAGGTTATAAATCATCACCAGACCAGTTTGTCGGCATCTTTGCTCAG
AATAGGCCAGAGTGGATCATCTCCGAATTGGCTTGTTACACGTACTCTATGGTAGCTGTA
CCTCTGTATGACACCTTGGGACCAGAAGCCATCGTACATATTGTCAACAAGGCTGATATC
GCCATGGTGATCTGTGACACACCCCAAAAGGCATTGGTGCTGATAGGGAATGTAGAGAAA
GGCTTCACCCCGAGCCTGAAGGTGATCATCCTTATGGACCCCTTTGATGATGACCTGAAG
CAAAGAGGGGAGAAGAGTGGAATTGAGATCTTATCCCTATATGATGCTGAGAACCTAGGC
AAAGAGCACTTCAGAAAACCTGTGCCTCCTAGCCCAGAAGACCTGAGCGTCATCTGCTTC
ACCAGTGGGACCACAGGTGACCCCAAAGGAGCCATGATAACCCATCAAAATATTGTTTCA
AATGCTGCTGCCTTTCTCAAATGTGTGGAGCATGCTTATGAGCCCACTCCTGATGATGTG
GCCATATCCTACCTCCCTCTGGCTCATATGTTTGAGAGGATTGTACAGGCTGTTGTGTAC
AGCTGTGGAGCCAGAGTTGGATTCTTCCAAGGGGATATTCGGTTGCTGGCTGACGACATG
AAGACTTTGAAGCCCACATTGTTTCCCGCGGTGCCTCGACTCCTTAACAGGATCTACGAT
AAGGTACAAAATGAGGCCAAGACACCCTTGAAGAAGTTCTTGTTGAAGCTGGCTGTTTCC
AGTAAATTCAAAGAGCTTCAAAAGGGTATCATCAGGCATGATAGTTTCTGGGACAAGCTC
ATCTTTGCAAAGATCCAGGACAGCCTGGGCGGAAGGGTTCGTGTAATTGTCACTGGAGCT
GCCCCCATGTCCACTTCAGTCATGACATTCTTCCGGGCAGCAATGGGATGTCAGGTGTAT
GAAGCTTATGGTCAAACAGAATGCACAGGTGGCTGTACATTTACATTACCTGGGGACTGG
ACATCAGGTCACGTTGGGGTGCCCCTGGCTTGCAATTACGTGAAGCTGGAAGATGTGGCT
GACATGAACTACTTTACAGTGAATAATGAAGGAGAGGTCTGCATCAAGGGTACAAACGTG
TTCAAAGGATACCTGAAGGACCCTGAGAAGACACAGGAAGCCCTGGACAGTGATGGCTGG
CTTCACACAGGAGACATTGGTCGCTGGCTCCCGAATGGAACTCTGAAGATCATCGACCGT
AAAAAGAACATTTTCAAGCTGGCCCAAGGAGAATACATTGCACCAGAGAAGATAGAAAAT
ATCTACAACAGGAGTCAACCAGTGTTACAAATTTTTGTACACGGGGAGAGCTTACGGTCA
TCCTTAGTAGGAGTGGTGGTTCCTGACACAGATGTACTTCCCTCATTTGCAGCCAAGCTT
GGGGTGAAGGGCTCCTTTGAGGAACTGTGCCAAAACCAAGTTGTAAGGGAAGCCATTTTA
GAAGACTTGCAGAAAATTGGGAAAGAAAGTGGCCTTAAAACTTTTGAACAGGTCAAAGCC
ATTTTTCTTCATCCAGAGCCATTTTCCATTGAAAATGGGCTCTTGACACCAACATTGAAA
GCAAAGCGAGGAGAGCTTTCCAAATACTTTCGGACCCAAATTGACAGCCTGTATGAGCAC
ATCCAGGATTAG

# Metabolic_Enzyme_104_GenBank_ID_Gene:
AB033899

# Metabolic_Enzyme_104_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_104_Locus:
10q25.1-q25.2

# Metabolic_Enzyme_104_SNPs:
rs3736946; rs12254915; rs11812261; rs11195943; rs1926564; rs11195936; rs2277208; rs8624; rs943260; rs11195938; rs7077197; rs7904386; rs10749118; rs3808920; rs4918747; rs10885342; rs9787487; rs7075592; rs7077060; rs4918744; rs12255316; rs2419621; rs11195940; rs17129748; rs11593532; rs17674469; rs11591311; rs11195942; rs4918745; rs7906445; rs11813362; rs10466200; rs4341465; rs11195939; rs3184349; rs12414442; rs7906780; rs7076991; rs4918748; rs11195949; rs876873; rs2900945; rs2419629; rs4333963; rs10885343; rs7904918; rs10787446; rs3736947; rs4501923; rs4351741; rs10885345; rs17129769; rs7919710; rs17129754; rs2419630; rs7904008; rs2419628; rs2256368; rs3740142; rs7068528; rs11598016; rs2255740; rs10885346; rs11195948; rs3780955; rs11195951; rs4918749; rs10787447; rs2419627; rs10885344; rs17129773; rs11195945; rs4439448; rs7477424; rs3981453; rs10885347; rs2419626; rs12779472; rs11195947; rs12258615; rs11195952; rs10509962; rs2419620; rs2256624; rs34719950; rs35183065; rs34585626; rs17129766; rs11195941; rs35907887; rs11484417; rs2148492; rs34575343; rs11195937; rs35808367; rs11368853; rs35383388; rs35865752; rs41292614; rs34055026; rs7097655; rs12773987; rs2234892; rs35583048; rs34096364; rs11312208; rs12218402; rs11556760; rs6144093; rs36000541; rs11195956; rs35482413; rs35032191; rs36047610; rs1887138; rs34852976; rs33994899; rs36038734; rs5787960; rs7097926; rs12242416; rs36108519; rs11389157; rs7093104; rs35097669; rs34088280; rs10614072; rs11286757; rs3840746; rs12778602; rs10736220; rs41292612; rs12768618; rs11385028; rs11195953; rs4572070; rs2290961; rs11420647; rs35238427; rs11195954; rs12769975; rs41292616; rs28559631; rs35942715; rs12769807; rs36089354; rs11195955; rs34258799; rs12768527; rs11195944; rs35708833; rs35777700; rs41306862; rs12768201; rs12768606; rs34850601; rs12221085; rs35770074; rs35514063; rs34659621; rs11195946; rs12769983; rs2616604; rs34678944; rs7899118; rs10635238; rs12266904; rs35166547; rs11385029; rs3831106; rs12769568; rs34341101; rs7097632; rs12570828; rs12249109; rs34684189; rs34799035; rs34129748; rs35529824; rs35568832; rs12769961; rs3830190; rs34709620; rs36004790; rs4918750; rs7477548; rs12769564; rs34464188; rs2251650; rs2234969; rs12249181; rs11311243; rs11311716; rs34021735; rs11382874; rs10509961; rs11598819; rs12098576; rs12268778; rs12356966; rs12414780; rs2094266; rs2290965; rs2306158; rs2419619; rs2419622; rs2900946; rs3180431; rs34823410; rs3736058; rs3736059; rs4314988; rs4550159; rs4917634; rs4917635; rs4918751; rs7070744; rs7100970; rs723373

# Metabolic_Enzyme_104_General_References:
12975309

# Metabolic_Enzyme_104_References:
Not Available

# Metabolic_Enzyme_105_ID:
5917

# Metabolic_Enzyme_105_Name:
Histidyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_105_Synonyms:
Histidine--tRNA ligase; HisRS

# Metabolic_Enzyme_105_Gene_Name:
HARS

# Metabolic_Enzyme_105_Protein_Sequence:
>HistidyltRNA synthetase, cytoplasmic
MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPK
GTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQ
GGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAG
NFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDK
LDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLG
DLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAG
GRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKL
LEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRS
VTSREEVDVRREDLVEEIKRRTGQPLCIC

# Metabolic_Enzyme_105_Number_of_Residues:
509

# Metabolic_Enzyme_105_Molecular_Weight:
57411

# Metabolic_Enzyme_105_Theoretical_pI:
5.56

# Metabolic_Enzyme_105_GO_Classification:
>>>
Function:  histidine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  histidyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  protein biosynthesis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_105_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_105_Specific_Function:
ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)

# Metabolic_Enzyme_105_Pathway:
map00340  Histidine metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_105_Reaction:
ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)

# Metabolic_Enzyme_105_Pfam_Domain_Function:
PF03129:HGTP_anticodon;
PF00587:tRNA-synt_2b;
PF00458:WHEP-TRS

# Metabolic_Enzyme_105_Signals:
None

# Metabolic_Enzyme_105_Transmembrane_Regions:
None

# Metabolic_Enzyme_105_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_105_EC_Link:
EC 6.1.1.21

# Metabolic_Enzyme_105_GenBank_ID_Protein:
32460

# Metabolic_Enzyme_105_SwissProt_ID:
SYHC_HUMAN (P12081)

# Metabolic_Enzyme_105_swissprot_Name:
Not Available

# Metabolic_Enzyme_105_Genecard_id:
HARS

# Metabolic_Enzyme_105_Geneatlas_id:
HARS

# Metabolic_Enzyme_105_hgnc_id:
HGNC:4816

# Metabolic_Enzyme_105_PDB_ID:
Not Available

# Metabolic_Enzyme_105_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_105_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_105_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_105_Gene_Sequence:
>1530 bp
ATGGCAGAGCGTGCGGCGCTGGAGGAGCTGGTGAAACTTCAGGGAGAGCGCGTGCGAGGC
CTCAAGCAGCAGAAGGCCAGCGCCGAGCTGATCGAGGAGGAGGTGGCGAAACTCCTGAAA
CTGAAGGCACAGCTGGGTCCTGATGAAAGCAAACAGAAATTTGTGCTCAAAACCCCCAAG
GGCACAAGAGACTATAGTCCCCGGCAGATGGCAGTTCGCGAGAAGGTGTTTGACGTAATC
ATCCGTTGCTTCAAGCGCCACGGTGCAGAAGTCATTGATACACCTGTATTTGAACTAAAG
GAAACACTGATGGGAAAGTATGGGGAAGACTCCAAGCTTATCTATGACCTGAAGGACCAG
GGCGGGGAGCTCCTGTCCCTTCGCTATGACCTCACTGTTCCTTTTGCTCGGTATTTGGCA
ATGAATAAACTGACCAACATTAAACGCTACCACATAGCAAAGGTATATCGGCGGGATAAC
CCAGCCATGACCCGTGGCCGATACCGGGAATTCTACCAGTGTGATTTTGACATTGCTGGG
AACTTTGATCCCATGATCCCTGATGCAGAGTGCCTGAAGATCATGTGCGAGATCCTGAGT
TCACTTCAGATAGGCGACTTCCTGGTCAAGGTAAACGATCGACGCATTCTAGATGGGATG
TTTGCTATCTGTGGTGTTTCTGACAGCAAGTTCCGTACCATCTGCTCCTCAGTAGACAAG
CTGGACAAGGTGTCCTGGGAAGAGGTGAAGAATGAGATGGTGGGAGAGAAGGGCCTTGCA
CCTGAGGTGGCTGACCGCATTGGGGACTATGTCCAGCAACATGGTGGGGTATCCCTGGTG
GAACAGCTGCTCCAGGATCCTAAACTATCCCAAAACAAGCAGGCCTTGGAGGGCCTGGGA
GACCTGAAGTTGCTCTTTGAGTACCTGACCCTATTTGGCATTGATGACAAAATCTCCTTT
GACCTGAGCCTTGCTCGAGGGCTGGATTACTACACTGGGGTGATCTATGAGGCAGTGCTG
CTACAGACCCCAGCCCAGGCAGGGGAAGAGCCCCTGGGTGTGGGCAGTGTGGCTGCTGGA
GGACGCTATGATGGGCTAGTGGGCATGTTCGACCCCAAAGGGCGCAAGGTGCCATGTGTG
GGGCTCAGCATTGGGGTGGAGCGGATTTTCTCCATCGTGGAACAGAGACTAGAGGCTTTG
GAGGAGAAGATACGGACCACGGAGACACAGGTGCTTGTGGCATCTGCACAGAAGAAGCTG
CTAGAGGAAAGACTAAAGCTTGTCTCAGAACTGTGGGATGCTGGGATCAAGGCTGAGCTG
CTGTACAAGAAGAACCCAAAGCTACTGAACCAGTTACAGTACTGTGAGGAGGCAGGCATC
CCACTGGTGGCTATCATCGGCGAGCAGGAACTCAAGGATGGGGTCATCAAGCTCCGTTCA
GTGACGAGCAGGGAAGAGGTGGATGTCCGAAGAGAAGACCTTGTGGAGGAAATCAAAAGG
AGAACAGGCCAGCCCCTCTGCATCTGCTGA

# Metabolic_Enzyme_105_GenBank_ID_Gene:
Z11518

# Metabolic_Enzyme_105_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_105_Locus:
5q31.3

# Metabolic_Enzyme_105_SNPs:
rs2230361; rs2073512; rs702396; rs11954514; rs811382; rs801185; rs801189; rs2530239; rs801186; rs1089305; rs812381; rs801187; rs6880190; rs11745372; rs1131045; rs1131041; rs1050250; rs1131042; rs1050246; rs1131040; rs1131035; rs1131034; rs1131039; rs1131046; rs1131036; rs1050247; rs1050249; rs1050251; rs1050248; rs1131032; rs1131043; rs1131038; rs1050245; rs1131033; rs1131044; rs1050252; rs11548124; rs1131037; rs35217222; rs6873628; rs1089304; rs34246519; rs34291233; rs35790592; rs2530240; rs10713463; rs10534451; rs4334930; rs7701545; rs5871749; rs801188; rs11344157; rs12653992; rs10534452; rs13180544; rs10300; rs1050222; rs10515510; rs1065342; rs12513490; rs12652092; rs13169368; rs17119056; rs2251860; rs2286394; rs2302104; rs2530234; rs2530241; rs2530242; rs2530243; rs2530245; rs2530246; rs2563302; rs2563304; rs2563305; rs2563312; rs2563314; rs2563335; rs3177856; rs3180057; rs34342435; rs34589480; rs34732372; rs34790864; rs35080423; rs35983033; rs3887397; rs6880619; rs6883035; rs7706544; rs7715879; rs801168

# Metabolic_Enzyme_105_General_References:
1549469; 3554142; 8406012; 7755634

# Metabolic_Enzyme_105_References:
Not Available

# Metabolic_Enzyme_106_ID:
5918

# Metabolic_Enzyme_106_Name:
Seryl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_106_Synonyms:
Seryl-tRNA(Ser/Secsynthetase; Serine--tRNA ligase; SerRS

# Metabolic_Enzyme_106_Gene_Name:
SARS

# Metabolic_Enzyme_106_Protein_Sequence:
>SeryltRNA synthetase, cytoplasmic
MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC
SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE
RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGF
EGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQL
SQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTC
FRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYH
IVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKV
EFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEP
SKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA

# Metabolic_Enzyme_106_Number_of_Residues:
514

# Metabolic_Enzyme_106_Molecular_Weight:
58778

# Metabolic_Enzyme_106_Theoretical_pI:
6.38

# Metabolic_Enzyme_106_GO_Classification:
>>>
Function:  serine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  seryl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_106_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_106_Specific_Function:
Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

# Metabolic_Enzyme_106_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_106_Reaction:
ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)

# Metabolic_Enzyme_106_Pfam_Domain_Function:
PF02403:Seryl_tRNA_N;
PF00587:tRNA-synt_2b

# Metabolic_Enzyme_106_Signals:
None

# Metabolic_Enzyme_106_Transmembrane_Regions:
None

# Metabolic_Enzyme_106_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_106_EC_Link:
EC 6.1.1.11

# Metabolic_Enzyme_106_GenBank_ID_Protein:
1050527

# Metabolic_Enzyme_106_SwissProt_ID:
SYSC_HUMAN (P49591)

# Metabolic_Enzyme_106_swissprot_Name:
Not Available

# Metabolic_Enzyme_106_Genecard_id:
SARS

# Metabolic_Enzyme_106_Geneatlas_id:
SARS

# Metabolic_Enzyme_106_hgnc_id:
HGNC:10537

# Metabolic_Enzyme_106_PDB_ID:
Not Available

# Metabolic_Enzyme_106_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_106_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_106_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_106_Gene_Sequence:
>1545 bp
ATGGTGCTGGATCTGGATTTGTTTCGGGTGGATAAAGGAGGGGACCCAGCCCTCATCCGA
GAGACGCAGGAGAAGCGCTTCAAGGACCCGGGACTAGTGGACCAGCTGGTGAAGGCAGAC
AGCGAGTGGCGACGATGTAGATTTCGGGCAGACAACTTGAGCAAGCTGAAGAACCTATGC
AGCAAGACAATCGGAGAGAAAATGAAGAAAAAAGAGCCAGTGGGAGATGATGAGTCTGTC
CCAGAGAATGTGCTGAGTTTCGATGACCTTACTGCAGACGCTTTAGCTAACCTGAAAGTC
TCACAAATCAAAAAAGTCCGACTCCTCATTGATGAAGCCATCCTGAAGTGTGACGCGGAG
CGGATAAAGTTGGAAGCAGAGCGGTTTGAGAACCTCCGAGAGATTGGGAACCTTCTGCAC
CCTTCTGTACCCATCAGTAACGATGAGGATGTGGACAACAAAGTAGAGAGGATTTGGGGC
GATTGTACAGTCAGGAAGAAGTACTCTCATGTGGACCTGGTGGTGATGGTAGATGGCTTT
GAAGGCGAAAAGGGGGCCGTGGTGGCTGGGAGTCGAGGGTACTTCTTGAAGGGGGTCCTG
GTGTTCCTGGAACAGGCTCTCATCCAGTATGCCCTTCGCACCTTGGGAAGTCGGGGCTAC
ATTCCCATTTATACCCCCTTTTTCATGAGGAAGGAGGTCATGCAGGAGGTGGCACAGCTC
AGCCAGTTTGATGAAGAACTTTATAAGGTGATTGGCAAAGGCAGTGAAAAGTCTGATGAC
AACTCCTATGATGAGAAGTACCTGATTGCCACCTCAGAGCAGCCCATTGCTGCCCTGCAC
CGGGATGAGTGGCTCCGGCCGGAGGACCTGCCCATCAAGTATGCTGGCCTGTCTACCTGC
TTCCGTCAGGAGGTGGGCTCCCATGGCCGTGACACCCGTGGCATCTTCCGAGTCCATCAG
TTTGAGAAGATTGAACAGTTTGTGTACTCATCACCCCATGACAACAAGTCATGGGAGATG
TTTGAAGAGATGATTACCACCGCAGAGGAGTTCTACCAGTCCCTGGGGATTCCTTACCAC
ATTGTGAATATTGTCTCAGGTTCTTTGAATCATGCTGCCAGTAAGAAGCTTGACCTGGAG
GCCTGGTTTCCGGGCTCAGGAGCCTTCCGTGAGTTGGTCTCCTGTTCTAATTGCACGGAT
TACCAGGCTCGCCGGCTTCGAATCCGATATGGGCAAACCAAGAAGATGATGGACAAGGTG
GAGTTTGTCCATATGCTCAATGCTACCATGTGCGCCACTACCCGTACCATCTGCGCCATC
CTGGAGAACTACCAGACAGAGAAGGGCATCACTGTGCCTGAGAAATTGAAGGAGTTCATG
CCGCCAGGACTGCAAGAACTGATCCCCTTTGTGAAGCCTGCGCCCATTGAGCAGGAGCCA
TCAAAGAAGCAGAAGAAGCAACATGAGGGCAGCAAAAAGAAAGCAGCAGCAAGAGACGTC
ACCCTAGAAAACAGGCTGCAGAACATGGAGGTCACCGATGCTTGA

# Metabolic_Enzyme_106_GenBank_ID_Gene:
X91257

# Metabolic_Enzyme_106_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_106_Locus:
1p13.3-p13.1

# Metabolic_Enzyme_106_SNPs:
rs608511; rs683182; rs3120625; rs669697; rs600711; rs658092; rs685653; rs7539716; rs4970832; rs2924; rs687074; rs584116; rs12028612; rs2182598; rs682612; rs642581; rs626704; rs11102960; rs4970831; rs4268379; rs626784; rs1277927; rs7552768; rs11102962; rs4970830; rs3118502; rs7537308; rs7547246; rs654040; rs9661235; rs12127592; rs3118501; rs17643426; rs17856306; rs11547491; rs11547492; rs1277925; rs2358959; rs12067741; rs11380452; rs41279696; rs12403825; rs35069915; rs34158040; rs12354027; rs34115802; rs657511; rs7539230; rs35425522; rs11339198; rs12749308; rs1556768; rs1277928; rs12075220; rs35018700; rs11311821; rs34647086; rs639608; rs2281895; rs12125002; rs5776968; rs639246; rs2485323; rs7544116; rs1556769; rs631927; rs34756917; rs12129083; rs4970829; rs11102959; rs34528252; rs11439617; rs607087; rs35694777; rs2358960; rs34812410; rs12128523; rs34133284; rs12130045; rs3120626; rs3834101; rs34159080; rs11375361; rs12754293; rs35376223; rs11436487; rs3203683; rs41279698; rs11306493; rs10624420; rs654469; rs35271870; rs11804423; rs12081406; rs35625457; rs7552765; rs1277926; rs34764041; rs6703402; rs11102955; rs11102957; rs11102964; rs11102965; rs12067069; rs1277921; rs17034539; rs17034541; rs17034619; rs17035415; rs17035443; rs3088350; rs3197233; rs4246519; rs4246520; rs4623734; rs4970827; rs585362; rs586254; rs587805; rs602265; rs603643; rs604500; rs607067; rs611060; rs611905; rs611945; rs663741; rs6656935; rs688386

# Metabolic_Enzyme_106_General_References:
9431993

# Metabolic_Enzyme_106_References:
Not Available

# Metabolic_Enzyme_107_ID:
5919

# Metabolic_Enzyme_107_Name:
Long-chain-fatty-acid--CoA ligase 3

# Metabolic_Enzyme_107_Synonyms:
Long-chain acyl-CoA synthetase 3; LACS 3

# Metabolic_Enzyme_107_Gene_Name:
ACSL3

# Metabolic_Enzyme_107_Protein_Sequence:
>LongchainfattyacidCoA ligase 3
MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPV
NSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPN
GKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACF
MYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGK
PPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMIS
HSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQ
SSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQI
SKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTES
AGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTMGYY
KNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAA
LKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLK
VLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK


# Metabolic_Enzyme_107_Number_of_Residues:
720

# Metabolic_Enzyme_107_Molecular_Weight:
80421

# Metabolic_Enzyme_107_Theoretical_pI:
8.51

# Metabolic_Enzyme_107_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_107_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_107_Specific_Function:
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates

# Metabolic_Enzyme_107_Pathway:
map00071  Fatty acid metabolism

# Metabolic_Enzyme_107_Reaction:
ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

# Metabolic_Enzyme_107_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_107_Signals:
1-31

# Metabolic_Enzyme_107_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_107_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_107_EC_Link:
EC 6.2.1.3

# Metabolic_Enzyme_107_GenBank_ID_Protein:
4165018

# Metabolic_Enzyme_107_SwissProt_ID:
ACSL3_HUMAN (O95573)

# Metabolic_Enzyme_107_swissprot_Name:
Not Available

# Metabolic_Enzyme_107_Genecard_id:
ACSL3

# Metabolic_Enzyme_107_Geneatlas_id:
ACSL3

# Metabolic_Enzyme_107_hgnc_id:
HGNC:3570

# Metabolic_Enzyme_107_PDB_ID:
Not Available

# Metabolic_Enzyme_107_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_107_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_107_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type III membrane protein. Peroxisome; peroxisomal membrane; single-pass type III membrane protein (By similarity). Microsome; microsomal membrane; single-pass type III membrane protein (By similarity)

# Metabolic_Enzyme_107_Gene_Sequence:
>2163 bp
ATGAATAACCACGTGTCTTCAAAACCATCTACCATGAAGCTAAAACATACCATCAACCCT
ATTCTTTTATATTTTATACATTTTCTAATATCACTTTATACTATTTTAACATACATTCCG
TTTTATTTTTTCTCCGAGTCAAGACAAGAAAAATCAAACCGAATTAAAGCAAAGCCTGTA
AATTCAAAACCTGATTCTGCATACAGATCTGTTAATAGTTTGGATGGTTTGGCTTCAGTA
TTATACCCTGGATGTGATACTTTAGATAAAGTTTTTACATATGCAAAAAACAAATTTAAG
AACAAAAGACTCTTGGGAACACGTGAAGTTTTAAATGAGGAAGATGAAGTACAACCAAAT
GGAAAAATTTTTAAAAAGGTTATTCTTGGACAGTATAATTGGCTTTCCTATGAAGATGTC
TTTGTTCGAGCCTTTAATTTTGGAAATGGATTACAGATGTTGGGTCAGAAACCAAAGACC
AACATCGCCATCTTCTGTGAGACCAGGGCCGAGTGGATGATAGCTGCACAGGCGTGTTTT
ATGTATAATTTTCAGCTTGTTACATTATATGCCACTCTAGGAGGTCCAGCCATTGTTCAT
GCATTAAATGAAACAGAGGTGACCAACATCATTACTAGTAAAGAACTCTTACAAACAAAG
TTGAAGGATATAGTTTCTTTGGTCCCACGCCTGCGGCACATCATCACTGTTGATGGAAAG
CCACCGACCTGGTCCGACTTCCCCAAGGGCATCATTGTGCATACCATGGCTGCAGTGGAG
GCCCTGGGAGCCAAGGCCAGCATGGAAAACCAACCTCATAGCAAACCATTGCCCTCAGAT
ATTGCAGTAATCATGTACACAAGTGGATCCACAGGACTTCCAAAGGGAGTCATGATCTCA
CATAGTAACATTATTGCTGGTATAACTGGGATGGCAGAAAGGATTCCAGAACTAGGAGAG
GAAGATGTCTACATTGGATATTTGCCTCTGGCCCATGTTCTAGAATTAAGTGCTGAGCTT
GTCTGTCTTTCTCACGGATGCCGCATTGGTTACTCTTCACCACAGACTTTAGCAGATCAG
TCTTCAAAAATTAAAAAAGGAAGCAAAGGGGATACATCCATGTTGAAACCAACACTGATG
GCAGCAGTTCCGGAAATCATGGATCGGATCTACAAAAATGTCATGAATAAAGTCAGTGAA
ATGAGTAGTTTTCAACGTAATCTGTTTATTCTGGCCTATAATTACAAAATGGAACAGATT
TCAAAAGGACGTAATACTCCACTGTGCGACAGCTTTGTTTTCCGGAAAGTTCGAAGCTTG
CTAGGGGGAAATATTCGTCTCCTGTTGTGTGGTGGCGCTCCACTTTCTGCAACCACGCAG
CGATTCATGAACATCTGTTTCTGCTGTCCTGTTGGTCAGGGATACGGGCTCACTGAATCT
GCTGGGGCTGGAACAATTTCCGAAGTGTGGGACTACAATACTGGCAGAGTGGGAGCACCA
TTAGTTTGCTGTGAAATCAAATTAAAAAACTGGGAGGAAGGTGGATACTTTAATACTGAT
AAGCCACACCCCAGGGGTGAAATTCTTATTGGGGGCCAAAGTGTGACAATGGGGTACTAC
AAAAATGAAGCAAAAACAAAAGCTGATTTCTCTGAAGATGAAAATGGACAAAGGTGGCTC
TGTACTGGGGATATTGGAGAGTTTGAACCCGATGGATGCTTAAAGATTATTGATCGTAAA
AAGGACCTTGTAAAACTACAGGCAGGGGAATATGTTTCTCTTGGGAAAGTAGAGGCAGCT
TTGAAGAATCTTCCACTAGTAGATAACATTTGTGCATATGCAAACAGTTATCATTCTTAT
GTCATTGGATTTGTTGTGCCAAATCAAAAGGAACTAACTGAACTAGCTCGAAAGAAAGGA
CTTAAAGGGACTTGGGAGGAGCTGTGTAACAGTTGTGAAATGGAAAATGAGGTACTTAAA
GTGCTTTCCGAAGCTGCTATTTCAGCAAGTCTGGAAAAGTTTGAAATTCCAGTAAAAATT
CGTTTGAGTCCTGAACCGTGGACCCCTGAAACTGGTCTGGTGACAGATGCCTTCAAGCTG
AAACGCAAAGAGCTTAAAACACATTACCAGGCGGACATTGAGCGAATGTATGGAAGAAAA
TAA

# Metabolic_Enzyme_107_GenBank_ID_Gene:
D89053

# Metabolic_Enzyme_107_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_107_Locus:
2q34-q35

# Metabolic_Enzyme_107_SNPs:
rs795876; rs12474230; rs795882; rs12998074; rs795888; rs6722420; rs4674719; rs10932977; rs795875; rs2119160; rs1011965; rs7561624; rs795884; rs795886; rs12105595; rs1046108; rs16864214; rs4477904; rs6719075; rs12471915; rs7596551; rs10439277; rs795892; rs10804309; rs12624299; rs795891; rs705727; rs10469668; rs7576552; rs12104813; rs6717500; rs4674730; rs795890; rs17780761; rs13031097; rs795881; rs795895; rs795894; rs1046109; rs795878; rs12620099; rs12468021; rs10183313; rs16864223; rs795883; rs2254744; rs795879; rs16864217; rs17838618; rs795887; rs4542842; rs12694584; rs795880; rs16864221; rs6718223; rs12694585; rs4674718; rs6718830; rs795889; rs11679363; rs2254743; rs16864237; rs16864201; rs17176871; rs16864206; rs13414173; rs17780803; rs4674729; rs4674720; rs795893; rs795874; rs1866661; rs6756107; rs3768979; rs1014280; rs2165231; rs1485; rs6726737; rs11689975; rs10932980; rs12694586; rs6756323; rs4674723; rs4674724; rs13393796; rs1440061; rs6734103; rs4674727; rs10202154; rs2028384; rs10755041; rs10195273; rs935025; rs1440060; rs6436359; rs10804310; rs4674721; rs2119161; rs6758680; rs6436362; rs2119157; rs6436361; rs13031981; rs10498144; rs7590226; rs6705231; rs10204692; rs11674966; rs17781935; rs2165235; rs11695891; rs11674961; rs3213905; rs11674416; rs1550419; rs6722786; rs4674722; rs7602022; rs13012131; rs6727725; rs36048754; rs935030; rs7606898; rs10755042; rs10755043; rs4273205; rs1046032; rs34626661; rs1802541; rs17854140; rs34336387; rs13000358; rs5838968; rs34577259; rs36065921; rs28656308; rs28699168; rs3997656; rs28493822; rs36096049; rs795877; rs11461046; rs35213364; rs8179626; rs10187725; rs28400352; rs3076926; rs35191505; rs2119159; rs35891556; rs33994644; rs28649204; rs2100065; rs28717371; rs35119789; rs35688859; rs13029225; rs13032040; rs795885; rs745246; rs4674714; rs10469669; rs35221740; rs11331027; rs33980054; rs10469670; rs28377223; rs28558419; rs8179628; rs28528808; rs35528989; rs34361522; rs4673042; rs10605018; rs28663659; rs28404973; rs34528925; rs35202862; rs28398302; rs6739444; rs13010036; rs6721226; rs28532346; rs28498974; rs28601880; rs8179629; rs28491161; rs28690910; rs10573099; rs34892893; rs34509695; rs35385155; rs28546181; rs13028279; rs13425612; rs11449718; rs13005650; rs7563167; rs34640732; rs13400287; rs28631212; rs35656414; rs35999325; rs34580617; rs10604823; rs3076928; rs10564643; rs13400197; rs10196623; rs34468357; rs5838967; rs35575997; rs35685810; rs35366410; rs34965512; rs5838965; rs28622494; rs10932976; rs1139961; rs11315051; rs28489259; rs13002795; rs11412579; rs35585948; rs10623105; rs13034896; rs5838966; rs33995774; rs1087865; rs35812917; rs7557653; rs10169861; rs10469667; rs28425616; rs28705099; rs35845392; rs3997652; rs28661727; rs5838969; rs13006287; rs9646876; rs13005876; rs1071621; rs28626732; rs34307763; rs28449223; rs13003291; rs28731005; rs11674956; rs6728234; rs35747682; rs16864233; rs5838970; rs6758013; rs11692000; rs7573347; rs28524829; rs11357504; rs4674726; rs35451327; rs35957788; rs35249874; rs34975444; rs1550420; rs5838972; rs10427163; rs11674957; rs35090606; rs34279120; rs34095647; rs5838973; rs34861997; rs4674725; rs11389330; rs36064590; rs1486; rs10607565; rs11460847; rs13413567; rs10932978; rs34262851; rs17177230; rs11402748; rs35079082; rs34016050; rs11675672; rs6436360; rs35177160; rs2165232; rs7573229; rs35356121; rs28718147; rs11891410; rs10932979; rs7595881; rs34431912; rs4521033; rs1550426; rs35965037; rs10172473; rs35381336; rs11691999; rs2165236; rs12623448; rs10804312; rs10174348; rs34942789; rs34403932; rs13413471; rs5838971; rs35545652; rs34031078; rs6739824; rs4353643; rs35350949; rs35644461; rs35218915; rs6744694; rs12233118; rs11397544; rs35724769; rs34054473; rs10170523; rs10183850; rs13009194; rs13388639; rs1473290; rs2034253; rs2053717; rs34780684; rs35355564; rs4330101; rs6436363; rs6436364; rs6547; rs6751070; rs7575760; rs7592063

# Metabolic_Enzyme_107_General_References:
9177793; 11707336

# Metabolic_Enzyme_107_References:
Not Available

# Metabolic_Enzyme_108_ID:
5920

# Metabolic_Enzyme_108_Name:
Leucyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_108_Synonyms:
Leucine--tRNA ligase; LeuRS

# Metabolic_Enzyme_108_Gene_Name:
LARS

# Metabolic_Enzyme_108_Protein_Sequence:
>LeucyltRNA synthetase, cytoplasmic
MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLH
LGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDE
EEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHW
LDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIY
SPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMF
GQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGA
SLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRD
DMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVD
GFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWK
KQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIY
MAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQ
EFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKS
TGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVAN
WDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAV
EGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQ
YLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFE
ANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVL
MENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGH
FSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTP
ISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH

# Metabolic_Enzyme_108_Number_of_Residues:
1176

# Metabolic_Enzyme_108_Molecular_Weight:
134468

# Metabolic_Enzyme_108_Theoretical_pI:
7.31

# Metabolic_Enzyme_108_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  leucine-tRNA ligase activity
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  protein biosynthesis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_108_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_108_Specific_Function:
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)

# Metabolic_Enzyme_108_Pathway:
map00290  Valine, leucine and isoleucine biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_108_Reaction:
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)

# Metabolic_Enzyme_108_Pfam_Domain_Function:
PF08264:Anticodon_1;
PF09334:tRNA-synt_1g

# Metabolic_Enzyme_108_Signals:
None

# Metabolic_Enzyme_108_Transmembrane_Regions:
None

# Metabolic_Enzyme_108_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_108_EC_Link:
EC 6.1.1.4

# Metabolic_Enzyme_108_GenBank_ID_Protein:
7804450

# Metabolic_Enzyme_108_SwissProt_ID:
SYLC_HUMAN (Q9P2J5)

# Metabolic_Enzyme_108_swissprot_Name:
Not Available

# Metabolic_Enzyme_108_Genecard_id:
LARS

# Metabolic_Enzyme_108_Geneatlas_id:
LARS

# Metabolic_Enzyme_108_hgnc_id:
HGNC:6512

# Metabolic_Enzyme_108_PDB_ID:
Not Available

# Metabolic_Enzyme_108_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_108_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_108_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_108_Gene_Sequence:
>3531 bp
ATGGCGGAAAGAAAAGGAACAGCCAAAGTGGACTTTTTGAAGAAGATTGAGAAAGAAATC
CAACAGAAATGGGATACTGAGAGAGTGTTTGAGGTCAATGCATCTAATTTAGAGAAACAG
ACCAGCAAGGGCAAGTATTTTGTAACCTTCCCATATCCATATATGAATGGACGCCTTCAT
TTGGGACACACGTTTTCTTTATCCAAATGTGAGTTTGCTGTAGGGTACCAGCGATTGAAA
GGAAAATGTTGTCTGTTTCCCTTTGGCCTGCACTGTACTGGAATGCCTATTAAGGCATGT
GCTGATAAGTTGAAAAGAGAAATAGAGCTGTATGGTTGCCCCCCTGATTTTCCAGATGAA
GAAGAGGAAGAGGAAGAAACCAGTGTTAAAACAGAAGATATAATAATTAAGGATAAAGCT
AAAGGAAAAAAGAGTAAAGCTGCTGCTAAAGCTGGATCTTCTAAATACCAGTGGGGCATT
ATGAAATCCCTTGGCCTGTCTGATGAAGAGATAGTAAAATTTTCTGAAGCAGAACATTGG
CTTGATTATTTCCCGCCACTGGCTATTCAGGATTTAAAAAGAATGGGTTTGAAGGTAGAC
TGGCGTCGTTCCTTCATCACCACTGATGTTAATCCTTACTATGATTCATTTGTCAGATGG
CAATTTTTAACATTAAGAGAAAGAAACAAAATTAAATTTGGGAAGCGGTATACAATTTAC
TCTCCGAAAGATGGACAGCCTTGCATGGATCATGATAGACAAACTGGAGAGGGTGTTGGA
CCTCAGGAATATACTTTACTCAAATTGAAGGCGCTTGAGCCATACCCATCTAAATTAAGT
GGCCTGAAAGGTAAAAATATTTTCTTGGTGGCTGCTACTCTCAGACCTGAGACCATGTTT
GGGCAGACAAATTGTTGGGTTCGTCCTGATATGAAGTACATTGGATTTGAGACGGTGAAT
GGTGATATATTCATCTGTACCCAAAAAGCAGCCAGGAATATGTCATACCAGGGCTTTACC
AAAGACAATGGCGTGGTGCCTGTTGTTAAGGAATTAATGGGGGAGGAAATTCTTGGTGCA
TCACTTTCTGCACCTTTAACATCATACAAGGTGATCTATGTTCTCCCAATGCTAACTATT
AAGGAGGATAAAGGCACTGGTGTGGTTACAAGTGTTCCTTCCGACTCCCCTGATGATATT
GCTGCCCTCAGAGACTTGAAGAAAAAGCAAGCCTTACGAGCAAAATATGGAATTAGAGAT
GACATGGTCTTGCCATTTGAGCCGGTGCCAGTCATTGAAATCCCAGGTTTTGGAAATCTT
TCTGCTGTAACCATTTGTGATGAGTTGAAAATTCAGAGCCAGAATGACCGGGAAAAACTT
GCAGAAGCAAAGGAGAAGATATATCTAAAAGGATTTTATGAGGGTATCATGTTGGTGGAT
GGATTTAAAGGACAGAAGGTTCAAGATGTAAAGAAGACTATTCAGAAAAAGATGATTGAC
GCTGGAGATGCACTTATTTACATGGAACCAGAGAAACAAGTGATGTCCAGGTCGTCAGAT
GAATGTGTTGTGGCTCTGTGTGACCAGTGGTACTTGGATTATGGAGAAGAGAATTGGAAG
AAACAGACATCTCAGTGCTTGAAGAACCTGGAAACATTCTGTGAGGAGACCAGGAGGAAT
TTTGAAGCCACCTTAGGTTGGCTACAAGAACATGCTTGCTCAAGAACTTATGGTCTAGGC
ACTCACCTGCCTTGGGATGAGCAGTGGCTGATTGAATCACTTTCTGACTCCACTATTTAC
ATGGCATTTTACACAGTTGCACACCTATTGCAGGGGGGTAACTTGCATGGACAGGCAGAG
TCTCCGCTGGGCATTAGACCGCAACAGATGACCAAGGAAGTTTGGGATTATGTTTTCTTC
AAGGAGGCTCCATTTCCTAAGACTCAGATTGCAAAGGAAAAATTAGATCAGTTAAAGCAG
GAGTTTGAATTCTGGTATCCTGTTGATCTTCGCGTCTCTGGCAAGGATCTTGTTCCAAAT
CATCTTTCATATTACCTTTATAATCATGTGGCTATGTGGCCGGAACAAAGTGATAAATGG
CCTACAGCTGTGAGAGCAAATGGACATCTCCTCCTGAACTCTGAGAAGATGTCAAAATCC
ACAGGCAACTTCCTCACTTTGACCCAAGCTATTGACAAATTTTCAGCAGATGGAATGCGT
TTGGCTCTGGCTGATGCTGGTGACACTGTAGAAGATGCCAACTTTGTGGAAGCCATGGCA
GATGCAGGTATTCTCCGTCTGTACACCTGGGTAGAGTGGGTGAAAGAAATGGTTGCCAAC
TGGGACAGCCTAAGAAGTGGTCCTGCCAGCACTTTCAATGATAGAGTTTTTGCCAGTGAA
TTGAATGCAGGAATTATAAAAACAGATCAAAACTATGAAAAGATGATGTTTAAAGAAGCT
TTGAAAACAGGGTTTTTTGAGTTTCAGGCCGCAAAAGATAAGTACCGTGAATTGGCTGTG
GAAGGGATGCACAGAGAACTTGTGTTCCGGTTTATTGAAGTTCAGACACTTCTCCTCGCT
CCATTCTGTCCACATTTGTGTGAGCACATCTGGACACTCCTGGGAAAGCCTGACTCAATT
ATGAATGCTTCATGGCCTGTGGCAGGTCCTGTGGATGAAGTTTTAATACACTCCTCACAG
TATCTTATGGAAGTAACACATGACCTTAGACTACGACTCAAGAACTATATGATGCCAGCT
AAAGGGAAGAAGACCGACAAACAACCCCTGCAGAAGCCCTCACATTGCACCATCTATGTG
GCAAAGAACTATCCACCTTGGCAACATACCACCCTGTCTGTTCTACGTAAACACTTTGAG
GCCAATAACGGAAAACTGCCTGACAACAAAGTCATTGCTAGTGAACTAGGCAGTATGCCA
GAACTGAAGAAATACATGAAGAAAGTCATGCCATTTGTTGCCATGATTAAGGAAAATCTG
GAGAAGATGGGGCCTCGTATTCTGGATTTGCAATTAGAATTTGATGAAAAGGCTGTGCTT
ATGGAGAATATAGTCTATCTGACTAATTCGCTTGAGCTAGAACACATAGAAGTCAAGTTT
GCCTCCGAAGCAGAAGATAAAATCAGGGAAGACTGCTGTCCTGGGAAACCACTTAATGTT
TTTAGAATAGAACCTGGTGTGTCCGTTTCTCTGGTGAATCCCCAGCCATCCAATGGCCAC
TTCTCAACCAAAATTGAAATCAAGCAAGGAGATAACTGTGATTCCATAATCAGGCGTTTA
ATGAAAATGAATCGAGGAATTAAAGACCTTTCCAAAGTGAAACTGATGAGATTTGATGAT
CCACTGTTGGGGCCTCGACGAGTTCCTGTCCTGGGAAAGGAGTACACCGAGAAGACCCCC
ATTTCTGAGCATGCTGTTTTCAATGTGGACCTCATGAGCAAGAAAATTCATCTGACTGAG
AATGGGATAAGGGTGGATATTGGCGATACAATAATCTATCTGGTTCATTAA

# Metabolic_Enzyme_108_GenBank_ID_Gene:
D84223

# Metabolic_Enzyme_108_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_108_Locus:
5q32

# Metabolic_Enzyme_108_SNPs:
rs10988; rs2895647; rs17104257; rs3763373; rs17493851; rs12188941; rs1395277; rs1054020; rs1395276; rs2963918; rs3828935; rs10515564; rs7728381; rs2962511; rs2963913; rs11951553; rs3822623; rs2939536; rs12153109; rs11948314; rs2963919; rs2063005; rs4413574; rs1911112; rs11167931; rs4705438; rs17104255; rs3797628; rs13178370; rs2963911; rs11952228; rs17492893; rs11167932; rs2962512; rs2292172; rs2939535; rs2962515; rs2895649; rs2939538; rs11954750; rs17492851; rs2963921; rs2292173; rs17492950; rs3749994; rs11958630; rs2962500; rs17426775; rs17427286; rs2962505; rs2400209; rs17428570; rs2963924; rs17500483; rs17428100; rs11948180; rs2962514; rs11953517; rs11954977; rs2400211; rs2895648; rs11954083; rs17500504; rs2963914; rs12186358; rs17426845; rs2963910; rs13153675; rs17428465; rs13161075; rs2963915; rs17427691; rs13161659; rs6871866; rs11955557; rs11949703; rs13171828; rs13162640; rs2963922; rs13178516; rs11948017; rs13161233; rs11954870; rs17104266; rs2962510; rs17500456; rs1911113; rs13182567; rs13161036; rs11167934; rs13154547; rs11955635; rs4705119; rs11955695; rs17104254; rs17104276; rs17104260; rs11954923; rs2939539; rs13176915; rs2939522; rs2895650; rs2963920; rs2939525; rs11949351; rs13186694; rs12189385; rs11167933; rs2962506; rs3812244; rs11957199; rs33914983; rs17104264; rs2939521; rs11741611; rs13162233; rs6884711; rs17493090; rs2962503; rs9686750; rs883639; rs2962513; rs11952281; rs12522922; rs17104268; rs13178840; rs2963923; rs11959805; rs13185805; rs2939520; rs2962507; rs13180113; rs10037835; rs2939527; rs2962502; rs2939537; rs11960724; rs11952340; rs12153238; rs17104250; rs2015248; rs17428724; rs4913065; rs17428647; rs16742; rs13186701; rs11540215; rs4913066; rs17104247; rs4913067; rs34823161; rs4549582; rs11540214; rs11540217; rs34192761; rs35861595; rs13171596; rs36005893; rs2108447; rs35008800; rs12055029; rs34774165; rs36095232; rs13159380; rs10225; rs12055173; rs6882243; rs35736365; rs10660135; rs2939530; rs2962509; rs1395275; rs11744010; rs35302388; rs34203668; rs2063004; rs2962504; rs10650026; rs35658996; rs13172010; rs3840516; rs34633760; rs13183171; rs2108448; rs34461274; rs2963917; rs3062189; rs11750558; rs34794547; rs2963916; rs35044843; rs2962508; rs34787435; rs6865204; rs13157279; rs13184702; rs34908228; rs35814921; rs28560221; rs10223249; rs34529192; rs34896615; rs35868039; rs2895651; rs34482773; rs35858532; rs34204322; rs2939528; rs12521535; rs34272709; rs35754955; rs35048686; rs35048100; rs35659985; rs34049009; rs13179517; rs7717715; rs35421875; rs4705398; rs2939531; rs2063003; rs34672485; rs2962501; rs13178755; rs34201197; rs11957830; rs6860704; rs11467105; rs33930619; rs2400210; rs34064705; rs11453686; rs35641727; rs2963908; rs35986267; rs34127596; rs3995492; rs13190467; rs35626574; rs10076614; rs4443471; rs11953039; rs35424128; rs10068337; rs34581962; rs35320822; rs35080569; rs2963909; rs4705440; rs35676277; rs36122632; rs10571244; rs35449023; rs36098188; rs10584471; rs34986741; rs2939526; rs35821418; rs34688497; rs36059140; rs34590254; rs4546439; rs13164711; rs35262581; rs35238125; rs12055030; rs9325003; rs13189448; rs2939529; rs34643439; rs6894533; rs34345997; rs35436549; rs13176784; rs10070154; rs13164882; rs7734517; rs4323275; rs34683303; rs34794113; rs2963907; rs10214195; rs35545858; rs35163711; rs35614174; rs33955938; rs35339866; rs35581472; rs6881275; rs36102990; rs36070404; rs35825928; rs35131794; rs28449376; rs35849077; rs34014355; rs11748295; rs4345358; rs34090359; rs34662124; rs28558310; rs34452275; rs28579770; rs34706167; rs11957888; rs35690977; rs35723465; rs35379206; rs34355060; rs34342344; rs11321164; rs11957745; rs35749752; rs34404385; rs34658033; rs35421100; rs35185759; rs10655743; rs10583489; rs35869904; rs34272346; rs4415127; rs28587686; rs7733143; rs34700156; rs34428386; rs13170112; rs33910134; rs11958216; rs13154735; rs13184596; rs13170127; rs2939532; rs5871957; rs13170115; rs10524796; rs33936514; rs3836839; rs34405762; rs3062188; rs7356532; rs35494851; rs11948951; rs11957998; rs12187128; rs12187913; rs12188066; rs12188581; rs13174055; rs17104298; rs17500927; rs2063002; rs2906815; rs2939534; rs2962516; rs2962544; rs2962545; rs2963935; rs2963937; rs34170515; rs34181648; rs35652702; rs4913064; rs6875971; rs7443214; rs7728631

# Metabolic_Enzyme_108_General_References:
10718198

# Metabolic_Enzyme_108_References:
Not Available

# Metabolic_Enzyme_109_ID:
5921

# Metabolic_Enzyme_109_Name:
Ubiquitin-conjugating enzyme E2 C

# Metabolic_Enzyme_109_Synonyms:
Ubiquitin-protein ligase C; Ubiquitin carrier protein C; UbcH10

# Metabolic_Enzyme_109_Gene_Name:
UBE2C

# Metabolic_Enzyme_109_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 
CMASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNL
FKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILK
EKWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP


# Metabolic_Enzyme_109_Number_of_Residues:
179

# Metabolic_Enzyme_109_Molecular_Weight:
19652

# Metabolic_Enzyme_109_Theoretical_pI:
7.50

# Metabolic_Enzyme_109_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_109_General_Function:
Not Available

# Metabolic_Enzyme_109_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Required for the destruction of mitotic cyclins

# Metabolic_Enzyme_109_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_109_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_109_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_109_Signals:
None

# Metabolic_Enzyme_109_Transmembrane_Regions:
None

# Metabolic_Enzyme_109_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_109_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_109_GenBank_ID_Protein:
2062373

# Metabolic_Enzyme_109_SwissProt_ID:
UBE2C_HUMAN (O00762)

# Metabolic_Enzyme_109_swissprot_Name:
Not Available

# Metabolic_Enzyme_109_Genecard_id:
UBE2C

# Metabolic_Enzyme_109_Geneatlas_id:
UBE2C

# Metabolic_Enzyme_109_hgnc_id:
HGNC:15937

# Metabolic_Enzyme_109_PDB_ID:
1I7K

# Metabolic_Enzyme_109_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_109_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_109_Subcellular_Location:
Not Available

# Metabolic_Enzyme_109_Gene_Sequence:
>540 bp
ATGGCTTCCCAAAACCGCGACCCAGCCGCCACTAGCGTCGCCGCCGCCCGTAAAGGAGCT
GAGCCGAGCGGGGGCGCCGCCCGGGGTCCGGTGGGCAAAAGGCTACAGCAGGAGCTGATG
ACCCTCATGATGTCTGGCGATAAAGGGATTTCTGCCTTCCCTGAATCAGACAACCTTTTC
AAATGGGTAGGGACCATCCATGGAGCAGCTGGAACAGTATATGAAGACCTGAGGTATAAG
CTCTCGCTAGAGTTCCCCAGTGGCTACCCTTACAATGCGCCCACAGTGAAGTTCCTCACG
CCCTGCTATCACCCCAACGTGGACACCCAGGGTAACATATGCCTGGACATCCTGAAGGAA
AAGTGGTCTGCCCTGTATGATGTCAGGACCATTCTGCTCTCCATCCAGAGCCTTCTAGGA
GAACCCAACATTGATAGTCCCTTGAACACACATGCTGCCGAGCTCTGGAAAAACCCCACA
GCTTTTAAGAAGTACCTGCAAGAAACCTACTCAAAGCAGGTCACCAGCCAGGAGCCCTGA


# Metabolic_Enzyme_109_GenBank_ID_Gene:
U73379

# Metabolic_Enzyme_109_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_109_Locus:
20q13.12

# Metabolic_Enzyme_109_SNPs:
rs440789; rs382494; rs6017695; rs4458269; rs910396; rs2868350; rs6104355; rs445503; rs368622; rs11537645; rs34158793; rs34343212; rs7352110; rs6065895; rs11537646; rs6124745; rs10644383; rs5841608; rs11697338; rs3080107; rs10688619; rs35875372; rs3080105; rs7346644; rs7344079; rs6017694; rs10644382; rs35855523; rs35590450; rs35674509; rs6130939; rs35783500; rs6094213; rs8122973; rs11086982; rs11906429; rs12624428; rs12625621; rs13038132; rs1804548; rs1966172; rs380973; rs3848711; rs3848712; rs389417; rs390386; rs399672; rs434227; rs4629; rs4812963; rs4812964; rs574268; rs6017697; rs6032552; rs6073920; rs6073923; rs6073924; rs6094214; rs6104356; rs6130938; rs6130940; rs6514062; rs6514063; rs7272593; rs7348743; rs8124479; rs8860

# Metabolic_Enzyme_109_General_References:
9122200; 11780052; 11927573

# Metabolic_Enzyme_109_References:
Not Available

# Metabolic_Enzyme_110_ID:
5922

# Metabolic_Enzyme_110_Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4A

# Metabolic_Enzyme_110_Synonyms:
DPDE2; PDE46

# Metabolic_Enzyme_110_Gene_Name:
PDE4A

# Metabolic_Enzyme_110_Protein_Sequence:
>cAMPspecific 3',5'cyclic phosphodiesterase 4
AMEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERER
QPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPG
RSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVT
PFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELD
WCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVE
IPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKT
DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM
LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG
VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVID
MVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPL
ELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD
LVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE
EISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYL
TQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGL
PSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT

# Metabolic_Enzyme_110_Number_of_Residues:
886

# Metabolic_Enzyme_110_Molecular_Weight:
98144

# Metabolic_Enzyme_110_Theoretical_pI:
4.87

# Metabolic_Enzyme_110_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_110_General_Function:
Not Available

# Metabolic_Enzyme_110_Specific_Function:
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate

# Metabolic_Enzyme_110_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_110_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_110_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_110_Signals:
None

# Metabolic_Enzyme_110_Transmembrane_Regions:
None

# Metabolic_Enzyme_110_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_110_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_110_GenBank_ID_Protein:
347120

# Metabolic_Enzyme_110_SwissProt_ID:
PDE4A_HUMAN (P27815)

# Metabolic_Enzyme_110_swissprot_Name:
Not Available

# Metabolic_Enzyme_110_Genecard_id:
PDE4A

# Metabolic_Enzyme_110_Geneatlas_id:
PDE4A

# Metabolic_Enzyme_110_hgnc_id:
HGNC:8780

# Metabolic_Enzyme_110_PDB_ID:
Not Available

# Metabolic_Enzyme_110_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_110_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_110_Subcellular_Location:
Isoform 4:Membrane; peripheral membrane protein. Note=Isoform 4 has propensity for association with membranes

# Metabolic_Enzyme_110_Gene_Sequence:
>2661 bp
ATGGAACCCCCGACCGTCCCCTCGGAAAGGAGCCTGTCTCTGTCACTGCCCGGGCCCCGG
GAGGGCCAGGCCACCCTGAAGCCTCCCCCGCAGCACCTGTGGCGGCAGCCTCGGACCCCC
ATCCGTATCCAGCAGCGCGGCTACTCCGACAGCGCGGAGCGCGCCGAGCGGGAGCGGCAG
CCGCACCGGCCCATAGAGCGCGCCGATGCCATGGACACCAGCGACCGGCCCGGCCTGCGC
ACGACCCGCATGTCCTGGCCCTCGTCCTTCCATGGCACTGGCACCGGCAGCGGCGGCGCG
GGCGGAGGCAGCAGCAGGCGCTTCGAGGCAGAGAATGGGCCGACACCATCTCCTGGCCGC
AGCCCCCTGGACTCGCAGGCGAGCCCAGGACTCGTGCTGCACGCCGGGGCGGCCACCAGC
CAGCGCCGGGAGTCCTTCCTGTACCGCTCAGACAGCGACTATGACATGTCACCCAAGACC
ATGTCCCGGAACTCATCGGTCACCAGCGAGGCGCACGCTGAAGACCTCATCGTAACACCA
TTTGCTCAGGTGCTGGCCAGCCTCCGGAGCGTCCGTAGCAACTTCTCACTCCTGACCAAT
GTGCCCGTTCCCAGTAACAAGCGGTCCCCGCTGGGCGGCCCCACCCCTGTCTGCAAGGCC
ACGCTGTCAGAAGAAACGTGTCAGCAGTTGGCCCGGGAGACTCTGGAGGAGCTGGACTGG
TGTCTGGAGCAGCTGGAGACCATGCAGACCTATCGCTCTGTCAGCGAGATGGCCTCGCAC
AAGTTCAAAAGGATGTTGAACCGTGAGCTCACACACCTGTCAGAAATGAGCAGGTCCGGA
AACCAGGTCTCAGAGTACATTTCCACAACATTCCTGGACAAACAGAATGAAGTGGAGATC
CCATCACCCACGATGAAGGAACGAGAAAAACAGCAAGCGCCGCGACCAAGACCCTCCCAG
CCGCCCCCGCCCCCTGTACCACACTTACAGCCCATGTCCCAAATCACAGGGTTGAAAAAG
TTGATGCATAGTAACAGCCTGAACAACTCTAACATTCCCCGATTTGGGGTGAAGACCGAT
CAAGAAGAGCTCCTGGCCCAAGAACTGGAGAACCTGAACAAGTGGGGCCTGAACATCTTT
TGCGTGTCGGATTACGCTGGAGGCCGCTCACTCACCTGCATCATGTACATGATATTCCAG
GAGCGGGACCTGCTGAAGAAATTCCGCATCCCGGTGGACACGATGGTGACATACATGCTG
ACGCTGGAGGATCACTACCACGCTGACGTGGCCTACCATAACAGCCTGCACGCAGCTGAC
GTGCTGCAGTCCACCCACGTACTGCTGGCCACGCCTGCACTAGATGCAGTGTTCACGGAC
CTGGAGATTCTCGCCGCCCTCTTCGCGGCTGCCATCCACGATGTGGATCACCCTGGGGTC
TCCAACCAGTTCCTCATCAACACCAATTCGGAGCTGGCGCTCATGTACAACGATGAGTCG
GTGCTCGAGAATCACCACCTGGCCGTGGGCTTCAAGCTGCTGCAGGAGGACAACTGCGAC
ATCTTCCAGAACCTCAGCAAGCGCCAGCGGCAGAGCCTACGCAAGATGGTCATCGACATG
GTGCTGGCCACGGACATGTCCAAGCACATGACCCTCCTGGCTGACCTGAAGACCATGGTG
GAGACCAAGAAAGTGACCAGCTCAGGGGTCCTCCTGCTAGATAACTACTCCGACCGCATC
CAGGTCCTCCGGAACATGGTGCACTGTGCCGACCTCAGCAACCCCACCAAGCCGCTGGAG
CTGTACCGCCAGTGGACAGACCGCATCATGGCCGAGTTCTTCCAGCAGGGTGACCGAGAG
CGCGAGCGTGGCATGGAAATCAGCCCCATGTGTGACAAGCACACTGCCTCCGTGGAGAAG
TCTCAGGTGGGTTTTATTGACTACATTGTGCACCCATTGTGGGAGACCTGGGCGGACCTT
GTCCACCCAGATGCCCAGGAGATCTTGGACACTTTGGAGGACAACCGGGACTGGTACTAC
AGCGCCATCCGGCAGAGCCCATCTCCGCCACCCGAGGAGGAGTCAAGGGGGCCAGGCCAC
CCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGAA
ATATCAATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCA
GGAGTCGAGGAAGCTCTGGATGCAACCATAGCCTGGGAGGCATCCCCGGCCCAGGAGTCG
TTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGACA
CAGCAGGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAG
GAATTCGTGGTTGCTGTAAGCCACAGCAGCCCCTCTGCCCTGGCTCTTCAAAGCCCCCTT
CTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCCC
TCCACGGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGT
GCCTGCGCAGGGACATTTGGGGAGGACACATCCGCACTCCCAGCTCCTGGTGGCGGGGGG
TCAGGTGGAGACCCTACCTGA

# Metabolic_Enzyme_110_GenBank_ID_Gene:
L20965

# Metabolic_Enzyme_110_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_110_Locus:
19p13.2

# Metabolic_Enzyme_110_SNPs:
rs1051738; rs2230190; rs2230189; rs7256672; rs3745258; rs4804134; rs2358681; rs10416143; rs7247481; rs7343073; rs1194098; rs11672021; rs1051736; rs3192116; rs35473931; rs35610871; rs3745260; rs3192124; rs3833220; rs7253115; rs12985883; rs3745259; rs34212445; rs2569755; rs35371416; rs12983959; rs2569756; rs2735389; rs5827100; rs11666164; rs10404367; rs12975524; rs34214178; rs35888394; rs10411816; rs34675916; rs12610073; rs35398762; rs34222169; rs33984348; rs34278258; rs35452057; rs12975511; rs34861232; rs12981823; rs12982685; rs1194097; rs4804504; rs35757023; rs12982917; rs35214617; rs34230915; rs4804503; rs35368894; rs12981546; rs12975530; rs3936362; rs35867809; rs2735390; rs10423080; rs2569758; rs2569765; rs12978292; rs2569766; rs12978315; rs2569757; rs2569763; rs12978301; rs2569759; rs2569761; rs12978366; rs2569764; rs2569762; rs12978582; rs2569760; rs12980133; rs35084366; rs12980191; rs12981218; rs35715070; rs34519818; rs35937838; rs10416653; rs11671269; rs2569767; rs2569768; rs4804505; rs8105602

# Metabolic_Enzyme_110_General_References:
8413254; 9677330; 2160582; 7772058; 7888306

# Metabolic_Enzyme_110_References:
Not Available

# Metabolic_Enzyme_111_ID:
5313

# Metabolic_Enzyme_111_Name:
Ectonucleoside triphosphate diphosphohydrolase 1

# Metabolic_Enzyme_111_Synonyms:
NTPDase 1; Ecto-ATP diphosphohydrolase; ATPDase; Lymphoid cell activation antigen; Ecto-apyrase; CD39 antigen

# Metabolic_Enzyme_111_Gene_Name:
ENTPD1

# Metabolic_Enzyme_111_Protein_Sequence:
>Ectonucleoside triphosphate diphosphohydrolase 1
MEDTKESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENVKYGIVLDAGSSHT
SLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQ
HQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWI
TINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFR
LYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTP
CTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAF
SAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYIL
SLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVFL
MVLFSLVLFTVAIIGLLIFHKPSYFWKDMV

# Metabolic_Enzyme_111_Number_of_Residues:
510

# Metabolic_Enzyme_111_Molecular_Weight:
57965

# Metabolic_Enzyme_111_Theoretical_pI:
6.29

# Metabolic_Enzyme_111_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_111_General_Function:
Not Available

# Metabolic_Enzyme_111_Specific_Function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation. Hydrolyzes ATP and ADP equally well

# Metabolic_Enzyme_111_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_111_Reaction:
ATP + 2 H2O = AMP + 2 phosphate

# Metabolic_Enzyme_111_Pfam_Domain_Function:
PF01150:GDA1_CD39

# Metabolic_Enzyme_111_Signals:
None

# Metabolic_Enzyme_111_Transmembrane_Regions:
17-37
479-499

# Metabolic_Enzyme_111_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_111_EC_Link:
EC 3.6.1.5

# Metabolic_Enzyme_111_GenBank_ID_Protein:
765256

# Metabolic_Enzyme_111_SwissProt_ID:
ENTP1_HUMAN (P49961)

# Metabolic_Enzyme_111_swissprot_Name:
Not Available

# Metabolic_Enzyme_111_Genecard_id:
ENTPD1

# Metabolic_Enzyme_111_Geneatlas_id:
ENTPD1

# Metabolic_Enzyme_111_hgnc_id:
HGNC:3363

# Metabolic_Enzyme_111_PDB_ID:
Not Available

# Metabolic_Enzyme_111_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_111_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_111_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential)

# Metabolic_Enzyme_111_Gene_Sequence:
>1533 bp
ATGGAAGATACAAAGGAGTCTAACGTGAAGACATTTTGCTCCAAGAATATCCTAGCCATC
CTTGGCTTCTCCTCTATCATAGCTGTGATAGCTTTGCTTGCTGTGGGGTTGACCCAGAAC
AAAGCATTGCCAGAAAACGTTAAGTATGGGATTGTGCTGGATGCGGGTTCTTCTCACACA
AGTTTATACATCTATAAGTGGCCAGCAGAAAAGGAGAATGACACAGGCGTGGTGCATCAA
GTAGAAGAATGCAGGGTTAAAGGTCCTGGAATCTCAAAATTTGTTCAGAAAGTAAATGAA
ATAGGCATTTACCTGACTGATTGCATGGAAAGAGCTAGGGAAGTGATTCCAAGGTCCCAG
CACCAAGAGACACCCGTTTACCTGGGAGCCACGGCAGGCATGCGGTTGCTCAGGATGGAA
AGTGAAGAGTTGGCAGACAGGGTTCTGGATGTGGTGGAGAGGAGCCTCAGCAACTACCCC
TTTGACTTCCAGGGTGCCAGGATCATTACTGGCCAAGAGGAAGGTGCCTATGGCTGGATT
ACTATCAACTATCTGCTGGGCAAATTCAGTCAGAAAACAAGGTGGTTCAGCATAGTCCCA
TATGAAACCAATAATCAGGAAACCTTTGGAGCTTTGGACCTTGGGGGAGCCTCTACACAA
GTCACTTTTGTACCCCAAAACCAGACTATCGAGTCCCCAGATAATGCTCTGCAATTTCGC
CTCTATGGCAAGGACTACAATGTCTACACACATAGCTTCTTGTGCTATGGGAAGGATCAG
GCACTCTGGCAGAAACTGGCCAAGGACATTCAGGTTGCAAGTAATGAAATTCTCAGGGAC
CCATGCTTTCATCCTGGATATAAGAAGGTAGTGAACGTAAGTGACCTTTACAAGACCCCC
TGCACCAAGAGATTTGAGATGACTCTTCCATTCCAGCAGTTTGAAATCCAGGGTATTGGA
AACTATCAACAATGCCATCAAAGCATCCTGGAGCTCTTCAACACCAGTTACTGCCCTTAC
TCCCAGTGTGCCTTCAATGGGATTTTCTTGCCACCACTCCAGGGGGATTTTGGGGCATTT
TCAGCTTTTTACTTTGTGATGAAGTTTTTAAACTTGACATCAGAGAAAGTCTCTCAGGAA
AAGGTGACTGAGATGATGAAAAAGTTCTGTGCTCAGCCTTGGGAGGAGATAAAAACATCT
TACGCTGGAGTAAAGGAGAAGTACCTGAGTGAATACTGCTTTTCTGGTACCTACATTCTC
TCCCTCCTTCTGCAAGGCTATCATTTCACAGCTGATTCCTGGGAGCACATCCATTTCATT
GGCAAGATCCAGGGCAGCGACGCCGGCTGGACTTTGGGCTACATGCTGAACCTGACCAAC
ATGATCCCAGCTGAGCAACCATTGTCCACACCTCTCTCCCACTCCACCTATGTCTTCCTC
ATGGTTCTATTCTCCCTGGTCCTTTTCACAGTGGCCATCATAGGCTTGCTTATCTTTCAC
AAGCCTTCATATTTCTGGAAAGATATGGTATAG

# Metabolic_Enzyme_111_GenBank_ID_Gene:
S73813

# Metabolic_Enzyme_111_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_111_Locus:
10q24

# Metabolic_Enzyme_111_SNPs:
rs3793744; rs3181132; rs1342790; rs3176883; rs3181124; rs1573112; rs3176891; rs2153913; rs3176890; rs10748643; rs7077566; rs4431963; rs6584033; rs4582902; rs10882665; rs6584026; rs2185818; rs10748649; rs4075310; rs3176881; rs5014871; rs7097489; rs7919196; rs4481960; rs4918968; rs10882664; rs1891534; rs7096610; rs10509686; rs7083960; rs4322324; rs3892344; rs3181123; rs4396219; rs4512761; rs4917715; rs7921242; rs7074403; rs1891536; rs4244321; rs2861152; rs1418709; rs3181131; rs2275759; rs4075311; rs10882671; rs4917714; rs1340837; rs6584027; rs3176885; rs7088952; rs12262943; rs11598475; rs4320886; rs17111156; rs11188486; rs10882676; rs7096248; rs3929900; rs4918969; rs4551688; rs7093453; rs3897983; rs2901874; rs10882673; rs4918971; rs2901873; rs2861153; rs6584031; rs10736092; rs7893677; rs3181129; rs4917707; rs11188497; rs7088961; rs7902190; rs10882660; rs2105359; rs6584028; rs7901116; rs7913082; rs10736093; rs3176884; rs7900927; rs4614366; rs10786236; rs2901872; rs7067762; rs11188485; rs7089668; rs4409759; rs7070507; rs11595122; rs10882670; rs10786235; rs1539433; rs7100137; rs7088584; rs11818540; rs10748648; rs4336964; rs10882675; rs1342791; rs4074424; rs4918970; rs3181122; rs12767650; rs3901451; rs11816167; rs11188475; rs3181121; rs7915345; rs3176887; rs2861151; rs6584030; rs4412693; rs11594340; rs7921000; rs7894940; rs3176882; rs7898379; rs11188496; rs3181118; rs3176886; rs10882661; rs10882666; rs7901386; rs2275760; rs7090320; rs12770849; rs3181125; rs7915682; rs3901450; rs11188501; rs10786237; rs7900546; rs10748644; rs10786234; rs7915087; rs7913018; rs7894676; rs7914736; rs1935816; rs1418710; rs10748645; rs10786233; rs7069234; rs4406763; rs10882662; rs11188502; rs7915308; rs3176889; rs7095489; rs11593761; rs7082531; rs7914286; rs2861154; rs7083411; rs3176888; rs10882663; rs7920372; rs10748647; rs12780375; rs12354848; rs7476775; rs11188484; rs11188495; rs12763743; rs10882668; rs4272738; rs11188488; rs7900841; rs7921302; rs11188492; rs10786238; rs12244606; rs7915499; rs10882669; rs11188498; rs7904990; rs11592584; rs12770313; rs10882674; rs11188504; rs3181127; rs7915380; rs3176894; rs3814159; rs3176893; rs3176895; rs3176892; rs1804825; rs12240959; rs4463786; rs34293555; rs34399092; rs35135296; rs11389794; rs3980180; rs10736091; rs11407296; rs11188487; rs11597953; rs11188493; rs5787157; rs4472866; rs4539246; rs34736818; rs34473397; rs35488296; rs35597960; rs4420188; rs35620983; rs5787162; rs9663685; rs35826614; rs7900437; rs34166835; rs10585205; rs11188508; rs34177114; rs36017526; rs3181128; rs10672739; rs4581382; rs5787158; rs12354620; rs12265109; rs11188494; rs11188482; rs4433506; rs34836127; rs34248770; rs35444953; rs35537802; rs3980181; rs34907927; rs35452058; rs34858625; rs7896855; rs35809029; rs11517041; rs11188479; rs35615283; rs34279173; rs12360382; rs34421483; rs34720050; rs34980662; rs35782220; rs11574649; rs11393527; rs7909739; rs7088411; rs12572063; rs34872816; rs12258207; rs5787161; rs11188481; rs11188511; rs28542865; rs35164560; rs4917705; rs7900229; rs11527887; rs35203111; rs3897464; rs34082135; rs34627984; rs35360884; rs11188509; rs34308669; rs35650706; rs11188506; rs4325249; rs35298724; rs35859772; rs11188510; rs5787159; rs1418711; rs11574648; rs34367283; rs34925455; rs34296389; rs11188480; rs11528098; rs34873600; rs7898964; rs34863917; rs11188489; rs34997042; rs3961946; rs35748815; rs35177231; rs12357414; rs11188490; rs12355114; rs34077465; rs35535706; rs35825117; rs35417010; rs9702308; rs4481957; rs35854596; rs11188505; rs7911911; rs5787163; rs34850860; rs12782273; rs11188477; rs11188491; rs12774334; rs3897465; rs11188473; rs9664384; rs11188503; rs33998152; rs11188483; rs4402217; rs35861909; rs35700869; rs3961947; rs35516259; rs11498722; rs5787160; rs34143181; rs10736094; rs11188466; rs11188469; rs11188471; rs11188512; rs11188513; rs11188514; rs12358481; rs12761960; rs12775598; rs12781189; rs17462179; rs17553401; rs1935815; rs2051052; rs2096218; rs2153914; rs2226163; rs3181114; rs3181115; rs3181116; rs3192654; rs34630379; rs34793678; rs4918966; rs6584022; rs6584023; rs7086986; rs7090630; rs7096317; rs7098750; rs7100644; rs7923971

# Metabolic_Enzyme_111_General_References:
7930580; 8996251; 10405171; 8529670; 9846014; 8955160; 8626624; 10636909

# Metabolic_Enzyme_111_References:
Not Available

# Metabolic_Enzyme_112_ID:
5923

# Metabolic_Enzyme_112_Name:
Valyl-tRNA synthetase

# Metabolic_Enzyme_112_Synonyms:
Valine--tRNA ligase; ValRS; Protein G7a

# Metabolic_Enzyme_112_Gene_Name:
VARS

# Metabolic_Enzyme_112_Protein_Sequence:
>ValyltRNA synthetase
MSTLYVSPHPDAFPSLRALIAARYGEAGEGPGWGGAHPRICLQPPPTSRTPFPPPRLPAL
EQGPGGLWVWGATAVAQLLWPAGLGGPGGSRAAVLVQQWVSYADTELIPAACGATLPALG
LRSSAQDPQAVLGALGRALSPLEEWLRLHTYLAGEAPTLADLAAVTALLLPFRYVLDPPA
RRIWNNVTRWFVTCVRQPEFRAVLGEVVLYSGARPLSHQPGPEAPALPKTAAQLKKEAKK
REKLEKFQQKQKIQQQQPPPGEKKPKPEKREKRDPGVITYDLPTPPGEKKDVSGPMPDSY
SPRYVEAAWYPWWEQQGFFKPEYGRPNVSAANPRGVFMMCIPPPNVTGSLHLGHALTNAI
QDSLTRWHRMRGETTLWNPGCDHAGIATQVVVEKKLWREQGLSRHQLGREAFLQEVWKWK
EEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSAAVTEAFVRLHEEGIIYRSTRLVNWSCT
LNSAISDIEVDKKELTGRTLLSVPGYKEKVEFGVLVSFAYKVQGSDSDEEVVVATTRIET
MLGDVAVAVHPKDTRYQHLKGKNVIHPFLSRSLPIVFDEFVDMDFGTGAVKITPAHDQND
YEVGQRHGLEAISIMDSRGALINVPPPFLGLPRFEARKAVLVALKERGLFRGIEDNPMVV
PLCNRSKDVVEPLLRPQWYVRCGEMAQAASAAVTRGDLRILPEAHQRTWHAWMDNIREWC
ISRQLWWGHRIPAYFVTVSDPAVPPGEDPDGRYWVSGRNEAEAREKAAKEFGVSPDKISL
QQDEDVLDTWFSSGLFPLSILGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKL
TGRLPFREVYLHAIVRDAHGRKMSKSLGNVIDPLDVIYGISLQGLHNQLLNSNLDPSEVE
KAKEGQKADFPAGIPECGTDALRFGLCAYMSQGRDINLDVNRILGYRHFCNKLWNATKFA
LRGLGKGFVPSPTSQPGGHESLVDRWIRSRLTEAVRLSNQGFQAYDFPAVTTAQYSFWLY
ELCDVYLECLKPVLNGVDQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRMP
QAPPSLCVTPYPEPSECSWKDPEAEAALELALSITRAVRSLRADYNLTRIRPDCFLEVAD
EATGALASAVSGYVQALASAGVVAVLALGAPAPQGCAVALASDRCSIHLQLQGLVDPARE
LGKLQAKRVEAQRQAQRLRERRAASGYPVKVPLEVQEADEAKLQQTEAELRKVDEAIALF
QKML

# Metabolic_Enzyme_112_Number_of_Residues:
1264

# Metabolic_Enzyme_112_Molecular_Weight:
140477

# Metabolic_Enzyme_112_Theoretical_pI:
7.63

# Metabolic_Enzyme_112_GO_Classification:
>>>
Function:  valine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  valyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_112_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_112_Specific_Function:
ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)

# Metabolic_Enzyme_112_Pathway:
map00290  Valine, leucine and isoleucine biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_112_Reaction:
ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)

# Metabolic_Enzyme_112_Pfam_Domain_Function:
PF08264:Anticodon_1;
PF00043:GST_C;
PF02798:GST_N;
PF00133:tRNA-synt_1

# Metabolic_Enzyme_112_Signals:
None

# Metabolic_Enzyme_112_Transmembrane_Regions:
None

# Metabolic_Enzyme_112_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_112_EC_Link:
EC 6.1.1.9

# Metabolic_Enzyme_112_GenBank_ID_Protein:
31545

# Metabolic_Enzyme_112_SwissProt_ID:
SYV_HUMAN (P26640)

# Metabolic_Enzyme_112_swissprot_Name:
Not Available

# Metabolic_Enzyme_112_Genecard_id:
VARS

# Metabolic_Enzyme_112_Geneatlas_id:
VARS

# Metabolic_Enzyme_112_hgnc_id:
HGNC:12651

# Metabolic_Enzyme_112_PDB_ID:
Not Available

# Metabolic_Enzyme_112_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_112_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_112_Subcellular_Location:
Not Available

# Metabolic_Enzyme_112_Gene_Sequence:
>3798 bp
ATGTCCACCCTCTACGTCTCCCCTCACCCAGATGCCTTCCCCAGCCTCCGAGCCCTCATA
GCCGCTCGCTATGGGGAGGCTGGGGAGGGTCCCGGATGGGGAGGAGCCCACCCCCGCATC
TGTCTCCAGCCACCCCCGACTAGCAGGACTAGCTTTCCCCCACCCCGCCTGCCGGCCCTG
GAGCAGGGGCCCGGTGGGCTCTGGGTGTGGGGGGCCACGGCTGTGGCCCAGCTGCTGTGG
CCAGCAGGCCTGGGGGGCCCAGGGGGCAGCCGGGCGGCTGTCCTTGTCCAACAGTGGGTC
AGTTACGCCGACACGGAGTTAATACCAGCTGCCTGTGGAGCAACGCTGCCGGCCCTGGGA
CTCCGAAGCTCGGCCCAGGACCCCCAGGCTGTGCTGGGGGCCCTGGGCAGGGCCCTGAGC
CCCTTGGAGGAGTGGCTTCGGCTGCACACCTACTTGGCCGGGGAGGCCCCCACTCTGGCT
GACCTGGCGGCTGTCACAGCCTTGCTGCTGCCTTTCCGATACGTCCTAGACCCACCTGCC
CGCCGGATCTGGAATAATGTGACTCGCTGGTTTGTCACGTGTGTCCGACAGCCAGAATTC
CGAGCCGTGCTAGGAGAAGTGGTTCTATACTCAGGAGCCAGGCCTCTCTCTCATCAGCCA
GGCCCCGAGGCTCCTGCCCTCCCAAAGACAGCTGCTCAGCTCAAGAAAGAGGCAAAGAAA
CGGGAGAAGCTAGAGAAATTCCAACAGAAGCAGAAGATCCAACAGCAGCAGCCACCTCCA
GGGGAGAAGAAACCAAAACCAGAGAAGAGGGAGAAACGGGATCCTGGGGTCATTACCTAT
GACCTCCCAACCCCACCCGGGGAAAAGAAAGATGTCAGTGGCCCCATGCCCGACTCCTAC
AGCCCTCGGTATGTGGAGGCTGCCTGGTACCCTTGGTGGGAGCAGCAGGGCTTCTTCAAG
CCAGAGTATGGGCGTCCTAATGTGTCAGCAGCAAATCCCCGAGGTGTCTTCATGATGTGC
ATCCCACCCCCCAATGTGACAGGCTCCCTGCACCTGGGCCATGCACTCACCAACGCCATC
CAGGACTCCCTGACTCGATGGCACCGCATGCGTGGGGAGACCACCCTGTGGAACCCTGGC
TGTGACCATGCAGGTATTGCCACCCAGGTGGTGGTGGAGAAGAAGCTATGGCGTGAGCAG
GGACTGAGCCGGCACCAGCTGGGCCGCGAGGCCTTTCTACAGGAAGTCTGGAAGTGGAAG
GAGGAGAAAGGTGACCGGATTTACCACCAGTTGAAGAAGCTTGGCAGCTCCTTGGACTGG
GATCGAGCCTGTTTCACCATGGACCCTAAACTCTCAGCAGCTGTGACAGAGGCCTTTGTC
CGGCTTCACGAGGAAGGCATCATCTATCGCAGTACCCGCCTTGTTAACTGGTCCTGCACC
CTCAACTCCGCCATCTCTGACATTGAGGTGGATAAGAAGGAGCTGACAGGTCGCACCCTG
CTCTCCGTGCCTGGCTACAAGGAGAAGGTGGAGTTCGGGGTCCTCGTGTCCTTTGCCTAT
AAGGTCCAAGGCTCAGATAGCGACGAGGAGGTGGTGGTGGCAACAACTCGGATCGAGACA
ATGCTGGGAGATGTGGCTGTAGCTGTGCACCCCAAAGATACCAGATACCAGCACCTGAAG
GGGAAGAACGTGATCCACCCATTCCTGTCTCGGAGCCTTCCCATTGTCTTCGATGAATTT
GTGGACATGGACTTTGGCACAGGTGCTGGGAAGATCACCCCCGCACATGACCAAAATGAC
TATGAAGTTGGGCAGCGGCACGGGCTGGAGGCCATCAGCATCATGGACTCCCGGGGGGGC
CCTCATCAATGTGCCTCCGCCTTTCCTGGGCCTGCCCAGGTTTTGAGGCCAGGAAAGCGG
TGCCTGGTGGCGCTGAAGGAGCGGGGACTGTTCCGTGGCATTGAGGACAACCCCATGGTG
GTGCCACTTTGCAACCGGTCGAAGGACGTGGTAGAGCCTCTGCTGCGGCCGCAGTGGTAC
GTTCGCTGCGGGGAGATGGCCCAGGCTGCCAGCGCCGCTGTGACTCGGGGTGACCTCCGC
ATCCTGCCTGAGGCCCATCAGCGCACATGGCATGCCTGGATGGACAACATCCGGGAGTGG
TGCATTTCCAGGCAGCTGTGGTGGGGCCATCGCATCCCAGCCTACTTTGTCACTGTCAGT
GACCCAGCGGTGCCCCCTGGGGAGGACCCTGATGGGCGGTACTGGGTGAGTGGACGCAAT
GAGGCGGAGGCCCGGGAGAAGGCAGCCAAGGAGTTCGGAGTGTCCCCTGACAAGATCAGT
CTCCAGCAAGATGAGGATGTATTGGATACCTGGTTCTTCTCTGGCCTCTTCCCCTTATCC
ATTTTGGGCTGGCCCAACCAGTCAGAAGACCTGAGTGTGTTCTACCCCGGGACACTGCTG
GAGACCGGTCATGACATCCTCTTCTTCTGGGTGGCCCGGATGGTCATGCTGGGCCTGAAG
CTCACGGGCAGGCTGCCCTTTAGAGAGGTCTACCTCCATGCCATCGTGCGAGATGCTCAC
GGCCGGAAGATGAGCAAGTCTCTAGGCAATGTCATCGATCCCCTGGACGTCATCTATGGA
ATCTCCCTGCAGGGCCTCCACAACCAGCTGCTGAACAGCAACCTGGATCCCAGCGAGGTG
GAGAAGGCCAAAGAAGGGCAGAAAGCTGACTTCCCAGCGGGGATTCCTGAATGTGGCACC
GATGCTCTCCGGTTTGGATTATGTGCCTACATGTCCCAGGGTCGTGACATCAACCTGGAT
GTGAACCGGATACTGGGTTACCGCCACTTCTGCAACAAGCTCTGGAATGCCACCAAGTTT
GCCCTTCGTGGCCTTGGGAAGGGTTTTGTGCCCTCACCCACCTCCCAGCCCGGAGGCCAT
GAGAGCCTGGTGGACCGCTGGATCCGCAGCCGCCTGACAGAGGCTGTGAGGCTCAGCAAT
CAAGGCTTCCAGGCCTACGACTTCCCGGCCGTCACCACTGCCCAGTACAGCTTCTGGCTC
TATGAGCTCTGTGATGTCTACTTGGAGTGCCTGAAACCTGTACTGAATGGGGTGGACCAG
GTGGCAGCTGAGTGTGCCCGCCAGACCCTGTACACTTGCCTGGACGTTGGCCTGCGGCTG
CTCTCACCCTTCATGCCCTTCGTGACGGAGGAGCTGTTCCAGAGGCTGCCCCGGAGGATG
CCGCAAGCTCCCCCTAGCCTCTGTGTTACCCCCTACCCGGAGCCCTCAGAGTGCTCCTGG
AAGGACCCCGAGGCAGAAGCCGCCCTTGAGCTGGCGCTAAGCATCACGCGAGCCGTGCGC
TCCCTGCGGGCCGACTACAACCTCACCCGGATCCGGCCTGACTGTTTCCTGGAAGTGGCG
GATGAGGCCACGGGCGCCCTGGCATCGGCGGTGTCGGGCTACGTGCAGGCCCTGGCCAGC
GCAGGTGTGGTGGCTGTTCTGGCCCTGGGGGCTCCCGCCCCCCAGGGTTGCGCTGTGGCT
CTGGCTTCTGATCGCTGCTCCATCCACCTGCAGCTTCAGGGGCTGGTGGACCCTGCACGG
GAGCTGGGCAAGCTGCAAGCCAAGCGAGTTGAGGCCCAGCGGCAGGCCCAGCGTCTGCGG
GAACGCCGTGCTGCCTCGGGCTATCCTGTCAAGGTGCCGCTCGAAGTCCAGGAGGCAGAT
GAAGCCAAGCTCCAACAGACAGAAGCAGAGCTCAGGAAGGTGGATGAGGCCATCGCCCTA
TTCCAGAAGATGCTGTGA

# Metabolic_Enzyme_112_GenBank_ID_Gene:
X59303

# Metabolic_Enzyme_112_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_112_Locus:
6p21.3

# Metabolic_Enzyme_112_SNPs:
Not Available

# Metabolic_Enzyme_112_General_References:
1898367; 14574404; 8428657

# Metabolic_Enzyme_112_References:
Not Available

# Metabolic_Enzyme_113_ID:
5924

# Metabolic_Enzyme_113_Name:
Adenylate kinase isoenzyme 5

# Metabolic_Enzyme_113_Synonyms:
ATP-AMP transphosphorylase

# Metabolic_Enzyme_113_Gene_Name:
AK5

# Metabolic_Enzyme_113_Protein_Sequence:
>Adenylate kinase isoenzyme 5
MGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLI
RDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVIC
MDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEG
TPEDVFLQLCTAIDSIIF

# Metabolic_Enzyme_113_Number_of_Residues:
198

# Metabolic_Enzyme_113_Molecular_Weight:
22088

# Metabolic_Enzyme_113_Theoretical_pI:
5.16

# Metabolic_Enzyme_113_GO_Classification:
>>>
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  adenylate kinase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleotide kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleoside triphosphate metabolism
Process:  purine ribonucleoside triphosphate metabolism
Process:  ATP metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_113_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_113_Specific_Function:
Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP

# Metabolic_Enzyme_113_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_113_Reaction:
ATP + AMP = 2 ADP

# Metabolic_Enzyme_113_Pfam_Domain_Function:
PF00406:ADK

# Metabolic_Enzyme_113_Signals:
None

# Metabolic_Enzyme_113_Transmembrane_Regions:
None

# Metabolic_Enzyme_113_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_113_EC_Link:
EC 2.7.4.3

# Metabolic_Enzyme_113_GenBank_ID_Protein:
4691541

# Metabolic_Enzyme_113_SwissProt_ID:
KAD5_HUMAN (Q9Y6K8)

# Metabolic_Enzyme_113_swissprot_Name:
Not Available

# Metabolic_Enzyme_113_Genecard_id:
AK5

# Metabolic_Enzyme_113_Geneatlas_id:
AK5

# Metabolic_Enzyme_113_hgnc_id:
HGNC:365

# Metabolic_Enzyme_113_PDB_ID:
Not Available

# Metabolic_Enzyme_113_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_113_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_113_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_113_Gene_Sequence:
>597 bp
ATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCCT
GGCTCTGGCAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTC
TCAACTGGCGAGCTCCTGCGTGAGGAACTGGCATCAGAATCTGAAAGAAGCAAATTGATC
AGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAAG
GAGGCCATGGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGG
GAGGTGAAGCAAGGGGAAGAGTTCGGACGCAGGATTGGAGACCCACAGTTGGTGATCTGT
ATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCTG
CCTGTGGACGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCC
ATCCCCGTGATCGCCTACTACGAGACAAAAACACAGCTACACAAGATAAATGCAGAGGGA
ACACCAGAGGACGTTTTTCTTCAACTCTGCACAGCTATTGACTCTATTATTTTCTGA

# Metabolic_Enzyme_113_GenBank_ID_Gene:
AF062595

# Metabolic_Enzyme_113_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_113_Locus:
1p31

# Metabolic_Enzyme_113_SNPs:
rs2803140; rs1167206; rs2815311; rs3509; rs10873950; rs2602946; rs4949811; rs2689680; rs6683829; rs10747353; rs1779173; rs7517796; rs2602945; rs1619903; rs4949788; rs12133976; rs6665543; rs6669724; rs2602944; rs7517698; rs7531431; rs2602943; rs6680763; rs3767031; rs4949660; rs7517717; rs3767030; rs7534033; rs11162308; rs2815313; rs2815324; rs1167214; rs1010195; rs1167202; rs2054020; rs1670617; rs2803152; rs2088518; rs1721163; rs2647486; rs1167205; rs2647497; rs1453982; rs2602936; rs2815319; rs1010196; rs1874817; rs2815325; rs2602934; rs1167201; rs1721165; rs1874819; rs2029768; rs1463324; rs2689683; rs1167212; rs1721166; rs936001; rs2602951; rs1909202; rs1377733; rs2647503; rs6672375; rs4949803; rs2251456; rs6696968; rs1874818; rs2803166; rs4949658; rs6681717; rs1377731; rs7547493; rs6680677; rs6675743; rs11808966; rs1721164; rs6603950; rs2815326; rs9324162; rs1498404; rs4949808; rs11162357; rs6667803; rs7545638; rs11162331; rs7514041; rs3911295; rs11162355; rs1167207; rs12564604; rs10873933; rs1823837; rs2815337; rs11162332; rs7517051; rs12049202; rs3844165; rs6684022; rs6658302; rs12079234; rs1993266; rs10873937; rs7524866; rs6663047; rs2803155; rs2803169; rs7514937; rs12044354; rs2054017; rs4949659; rs11162309; rs12040471; rs7537472; rs7518696; rs10873947; rs2815310; rs10493603; rs10873935; rs7545544; rs7512893; rs9324161; rs10782645; rs11162323; rs12567557; rs7531286; rs9787153; rs12565526; rs4949792; rs11162340; rs6662853; rs6691415; rs11162330; rs3844166; rs7546131; rs12079206; rs11162311; rs2647491; rs7522356; rs2647510; rs2815314; rs6696083; rs11162356; rs2247536; rs11810135; rs12074409; rs2034708; rs1532508; rs10747354; rs2803136; rs4949809; rs6704141; rs11162333; rs4949794; rs4245658; rs4033036; rs12076479; rs2803168; rs1616948; rs10782651; rs7515509; rs10782648; rs10873938; rs7537574; rs6703133; rs1823838; rs7542588; rs17100513; rs12142918; rs4351702; rs17100319; rs6668429; rs2351034; rs12130313; rs7534707; rs17100436; rs2689676; rs17100231; rs9633480; rs4949793; rs10873941; rs17100521; rs9633479; rs11162351; rs1779177; rs12136415; rs2349966; rs12568374; rs1498405; rs17100224; rs2647519; rs1670612; rs11806344; rs17100305; rs17100509; rs12132273; rs3767036; rs11584919; rs2815307; rs1603743; rs2799555; rs6673059; rs11162341; rs12125503; rs1167196; rs10493536; rs2882289; rs2198511; rs7546963; rs12140227; rs12093263; rs12141929; rs7514177; rs11583090; rs3112826; rs7529652; rs11585310; rs2803147; rs2799562; rs3896705; rs10518553; rs1498402; rs4949655; rs9439799; rs6695572; rs6603948; rs11162347; rs10873945; rs7512897; rs12568528; rs1616272; rs2647508; rs2133203; rs17379910; rs1377736; rs3112830; rs7551211; rs4600093; rs11162319; rs1453974; rs11806197; rs6695989; rs2349965; rs11162312; rs10518551; rs1532509; rs1565850; rs3738079; rs11588898; rs2815323; rs11162334; rs17100274; rs1874816; rs2647499; rs4033035; rs17098286; rs11585455; rs6698295; rs1167215; rs1670618; rs12069838; rs1377732; rs12030598; rs1167217; rs10493605; rs1377734; rs12095801; rs11162350; rs7549462; rs12037071; rs2256679; rs11590456; rs10493606; rs11809786; rs2799553; rs17380592; rs1869467; rs4949802; rs6667519; rs6661765; rs12407481; rs7521772; rs7536307; rs17100646; rs2799561; rs2247742; rs2602927; rs1670611; rs12564592; rs1565851; rs2246124; rs6702968; rs6697255; rs12724560; rs2803153; rs7536433; rs2172727; rs7537603; rs1840246; rs17100317; rs4033037; rs6685087; rs12404204; rs6675781; rs12070870; rs6689581; rs10782647; rs3911801; rs12568376; rs7531411; rs17380852; rs17100308; rs1551331; rs12569104; rs5018314; rs1353727; rs3767033; rs4949800; rs4949799; rs12124822; rs17380036; rs10493602; rs10873934; rs11162352; rs10873944; rs1779178; rs3767035; rs4949654; rs9324160; rs1498400; rs17100499; rs17098287; rs7536818; rs11162326; rs2602948; rs2602953; rs12022440; rs9787060; rs12123060; rs4949789; rs3896706; rs17100674; rs1498403; rs17380796; rs7528932; rs6659899; rs17100570; rs10782646; rs10493604; rs12402184; rs6703688; rs1498399; rs17100524; rs2133204; rs3767032; rs12760589; rs12079316; rs6687876; rs7554922; rs3121778; rs12030302; rs11162336; rs12565558; rs11583735; rs11807111; rs12079185; rs17100458; rs17378915; rs2245189; rs7519901; rs11800652; rs1498401; rs7367731; rs17384946; rs2647515; rs6603949; rs1498407; rs4491097; rs11162310; rs12062661; rs2602937; rs12080101; rs3767034; rs1869468; rs17100204; rs12071212; rs17100218; rs11162335; rs2647525; rs17100475; rs12133318; rs17098226; rs1167216; rs17380544; rs10735750; rs12030818; rs7516637; rs11162364; rs936004; rs12068040; rs1823840; rs11162324; rs17100654; rs2602932; rs6704312; rs12754926; rs6603951; rs1353726; rs7517486; rs1869466; rs2803144; rs2803164; rs4949798; rs12048207; rs7537639; rs12031867; rs10873936; rs17100731; rs4431892; rs12073309; rs12128049; rs2689684; rs12733666; rs11162348; rs2803149; rs3962875; rs1167200; rs7532748; rs4949656; rs4949791; rs12131772; rs12726963; rs6674790; rs17100672; rs2349964; rs2647523; rs11162362; rs2799550; rs2647487; rs17100422; rs12404374; rs7527150; rs12073962; rs6680888; rs2647517; rs1779175; rs3862893; rs12741939; rs2815335; rs6680716; rs11162339; rs7516300; rs4949807; rs10127564; rs2054019; rs17100172; rs17100677; rs11590086; rs2602940; rs12144794; rs1377737; rs7551729; rs12066994; rs17100185; rs12736701; rs1532511; rs17100655; rs9439800; rs10782654; rs12730089; rs2602942; rs6603940; rs12060669; rs3113637; rs12037848; rs11162327; rs2815305; rs7415865; rs2799554; rs12092582; rs2647512; rs7529083; rs2803139; rs4949797; rs2803162; rs6673604; rs12404342; rs1167198; rs2647522; rs11162337; rs2647484; rs12740982; rs2803157; rs11811611; rs7519476; rs7546116; rs12401953; rs12034899; rs1615404; rs2351032; rs4949805; rs2256735; rs1670616; rs17380099; rs1167209; rs7550626; rs2647520; rs12045755; rs11585860; rs2803160; rs1721167; rs2815309; rs4589153; rs4949653; rs2123799; rs1167213; rs6603943; rs2602949; rs2647514; rs1909203; rs12080110; rs4245657; rs11162363; rs11162329; rs7524147; rs10873949; rs12033923; rs12409322; rs12062754; rs11162358; rs2351033; rs12070567; rs2815331; rs12047928; rs1010061; rs9633478; rs2647504; rs17100377; rs7532803; rs17100440; rs6603941; rs11162342; rs17100692; rs2647493; rs2133202; rs7512141; rs1966873; rs12730972; rs17100476; rs2221084; rs2647498; rs12046197; rs17385141; rs12135843; rs2647526; rs17100241; rs12077615; rs12567785; rs2799551; rs17100198; rs17100556; rs12065923; rs4402168; rs12093881; rs1532507; rs12731886; rs17379082; rs2602931; rs2647516; rs3104461; rs2815317; rs2815306; rs17100694; rs11162317; rs6694630; rs13376422; rs2815327; rs17371324; rs10873939; rs2154090; rs6603952; rs10873942; rs4949790; rs17100478; rs17100364; rs12745549; rs17100425; rs12085340; rs12122210; rs1167210; rs6603953; rs1377738; rs17100530; rs17100456; rs7545096; rs12751064; rs12042177; rs2815320; rs12097089; rs12030606; rs2803163; rs1909204; rs11583934; rs2803156; rs2054018; rs2647494; rs1670609; rs2647521; rs3104467; rs2815334; rs1976334; rs10873930; rs2996486; rs17100463; rs2799563; rs6671137; rs6698996; rs2167994; rs1377735; rs1779181; rs7546409; rs4949806; rs11162338; rs2799552; rs11162313; rs1670605; rs2803148; rs12729914; rs12404245; rs2602941; rs12751884; rs10873946; rs7543460; rs11162318; rs2803161; rs12095064; rs1453981; rs11162325; rs2647496; rs2647485; rs2647513; rs2815312; rs12031094; rs17100429; rs6692369; rs1167204; rs17695152; rs17100304; rs2647506; rs1167197; rs10873932; rs2799560; rs2803150; rs1013399; rs6693999; rs7528552; rs4949804; rs7511768; rs1851736; rs2004962; rs2799568; rs6697938; rs12126361; rs3835545; rs12028798; rs41292256; rs35474678; rs35528982; rs10577779; rs34360007; rs28476720; rs3835546; rs28605112; rs12184282; rs34108682; rs2647490; rs34641015; rs41292264; rs5775404; rs35194423; rs3077577; rs28701620; rs34309381; rs5775392; rs4539179; rs3113636; rs3032910; rs5024339; rs34342162; rs10618389; rs35528361; rs12239674; rs34939965; rs6699414; rs35045554; rs34509475; rs12752648; rs12747320; rs2803171; rs10610715; rs12737543; rs12753797; rs10643921; rs34198954; rs35490046; rs4491099; rs4567326; rs2133205; rs2803146; rs33950044; rs2803137; rs36066707; rs41292268; rs34561659; rs12747609; rs12130867; rs34444999; rs10581719; rs5775400; rs35473006; rs34632021; rs35962579; rs34563024; rs28482266; rs1670614; rs35364802; rs34520920; rs11585233; rs34026852; rs34899933; rs34781584; rs34093068; rs11351073; rs2799558; rs35905985; rs3112828; rs36121999; rs11275907; rs5775406; rs35340213; rs12089562; rs1470898; rs34216425; rs35100611; rs6603942; rs2647492; rs12737982; rs3113639; rs35597576; rs6660312; rs34812657; rs5775394; rs3911296; rs11306378; rs12754946; rs5775386; rs12741407; rs6659799; rs6663792; rs34544896; rs35047787; rs10672519; rs34500185; rs35425557; rs34578405; rs11384873; rs11331001; rs2647502; rs41292266; rs34019719; rs2815328; rs12754430; rs34579463; rs4033046; rs2882564; rs4033034; rs1779180; rs12738950; rs12089711; rs35137146; rs34732222; rs1973057; rs35367032; rs34776258; rs4546964; rs3892546; rs1936437; rs3122396; rs2803154; rs35752791; rs11310843; rs34997978; rs11162328; rs10658959; rs5775396; rs1840247; rs34814131; rs34219620; rs41306633; rs9439784; rs34229344; rs12065811; rs34800536; rs12760955; rs10641799; rs12742485; rs4949801; rs5775408; rs35923030; rs35263113; rs2647488; rs1453975; rs12088702; rs7417258; rs1532510; rs3077617; rs11585641; rs34191126; rs3104462; rs12025030; rs35881426; rs2647524; rs5775388; rs35160863; rs34079169; rs3104466; rs6700151; rs2454328; rs11583478; rs12731521; rs34781573; rs28635212; rs1721168; rs12129136; rs11355323; rs35670415; rs35883964; rs41428048; rs17381128; rs12145231; rs6664497; rs5775409; rs3913229; rs12095237; rs4420134; rs28858546; rs35866723; rs34676920; rs2602929; rs36053089; rs35157453; rs34570834; rs2803142; rs28560013; rs11287373; rs5775390; rs34854145; rs2256812; rs12039708; rs35838303; rs4562674; rs6660313; rs35754175; rs1498409; rs7532905; rs1167211; rs3100632; rs11583481; rs12240043; rs35205007; rs12137455; rs17100210; rs34162977; rs35651270; rs35751413; rs10687945; rs34192042; rs34581049; rs721514; rs4317858; rs12741389; rs4033042; rs3104464; rs3121777; rs12753082; rs34374541; rs12059542; rs34624933; rs4342893; rs2803167; rs35029067; rs12079001; rs10635433; rs35612924; rs36055551; rs6670567; rs12732540; rs36024544; rs34721376; rs17100430; rs1779176; rs2803135; rs12034210; rs2647505; rs11387882; rs35916064; rs2018388; rs34276249; rs12406551; rs11162345; rs34517694; rs12731983; rs12024819; rs6657424; rs11577058; rs2602939; rs11455000; rs28878211; rs11356289; rs11585642; rs1779179; rs5775398; rs10873948; rs33942843; rs1179473; rs6668328; rs34038217; rs35032414; rs10651968; rs12746354; rs4604738; rs10589201; rs11428852; rs34783496; rs12140779; rs7411262; rs35038885; rs10625327; rs12563604; rs12743457; rs12022986; rs12732561; rs34335914; rs34567357; rs34828972; rs35304863; rs35393140; rs35973848; rs11290615; rs35239700; rs1167203; rs2799556; rs35844658; rs12756901; rs28823938; rs34391713; rs10673675; rs28608963; rs12133202; rs12071077; rs28541326; rs28395330; rs12035195; rs2803159; rs5775399; rs2803138; rs11411925; rs12757491; rs34996477; rs7520851; rs11305805; rs28890262; rs10873940; rs3112829; rs2803143; rs10700476; rs35298406; rs6699130; rs34919195; rs2799559; rs3100631; rs1453976; rs35412216; rs34463378; rs10568838; rs3104463; rs34277277; rs12057706; rs12735196; rs2088517; rs34167936; rs34565581; rs5775393; rs34710967; rs4033040; rs36008355; rs34131257; rs12070404; rs2803165; rs34141642; rs12046067; rs35729964; rs7416803; rs33994249; rs35251829; rs12068504; rs7549417; rs34395455; rs4949657; rs35480521; rs34496684; rs4351701; rs12135900; rs5775383; rs2647501; rs1936438; rs7417209; rs35272247; rs4556409; rs1498408; rs3851266; rs10586398; rs12731121; rs7417056; rs6700681; rs3077570; rs34667944; rs35282414; rs7411526; rs12043793; rs34360551; rs6670430; rs35772583; rs12126330; rs17381238; rs35427612; rs34979299; rs5775397; rs9439819; rs1177502; rs7546981; rs12137672; rs11162361; rs9661264; rs5775407; rs2647489; rs1183243; rs34506812; rs34623145; rs35352712; rs12172739; rs12404451; rs34996626; rs12132133; rs12034334; rs3921995; rs3077541; rs34619075; rs35087048; rs34407415; rs2815333; rs34865607; rs1823839; rs12756133; rs28483962; rs2647518; rs12041666; rs12737014; rs5775387; rs11380102; rs12753538; rs4033045; rs34103321; rs36089522; rs34975081; rs10712325; rs34855794; rs5024338; rs2602933; rs36075033; rs34140909; rs35254623; rs12125923; rs34652234; rs10587637; rs2647495; rs34326091; rs34568620; rs36051497; rs34404890; rs2123796; rs36083236; rs2803170; rs5775395; rs2803151; rs6664913; rs12752918; rs11324649; rs35305856; rs35569847; rs12738273; rs12072100; rs1670610; rs10526328; rs34679101; rs12088013; rs12139240; rs11162346; rs12748599; rs34775316; rs34657715; rs35836390; rs12568051; rs12042881; rs34907598; rs12732787; rs2803141; rs2815329; rs34425821; rs41292260; rs35060423; rs35692250; rs11364704; rs35126601; rs11350511; rs35709353; rs12566093; rs3862894; rs28631005; rs34206262; rs10547281; rs10637505; rs35587548; rs35216620; rs12144818; rs36098400; rs5775382; rs33980298; rs35783103; rs12728752; rs36087243; rs28644426; rs28369006; rs3112825; rs3113640; rs12742953; rs35463751; rs12737366; rs12041509; rs35548350; rs34365360; rs12036958; rs34291857; rs1670615; rs36057604; rs35886747; rs33929714; rs12062613; rs35328311; rs35478846; rs34396257; rs35475576; rs2088519; rs7410994; rs34155195; rs2602938; rs11162344; rs36116132; rs34186386; rs7524107; rs3122366; rs10625085; rs35690647; rs34506775; rs2815336; rs36099665; rs36120231; rs12735922; rs35335455; rs12061595; rs3113638; rs12125332; rs34783278; rs34235538; rs34221500; rs35740273; rs2123798; rs3112827; rs12069995; rs35413139; rs11440245; rs1167208; rs35185203; rs3104465; rs34818192; rs17100630; rs4638175; rs17100538; rs12078902; rs41292262; rs2647507; rs2799557; rs5775391; rs35635429; rs35462161; rs1167199; rs5775403; rs12097728; rs5775389; rs28776274; rs2454329; rs2803158; rs34422174; rs11347735; rs12747284; rs10700619; rs35500871; rs41301251; rs12239270; rs4033041; rs10524122; rs11345707; rs34298832; rs35111545; rs7416385; rs34178467; rs12130891; rs34646507; rs12030935; rs12094209; rs7413421; rs2602928; rs10647386; rs1670613; rs34698864; rs2351031; rs1869469; rs2029769; rs12066590; rs34451301; rs35009400; rs12030994; rs12136831; rs6685119; rs35260482; rs11807469; rs12135530; rs35930501; rs35487420; rs1851735; rs11580677; rs35371663; rs2272161; rs34538335; rs1027354; rs10493537; rs10493601; rs10518446; rs10735749; rs11162306; rs11162307; rs11162365; rs12062309; rs12065011; rs12076331; rs12126117; rs12132703; rs12142405; rs12759796; rs13806; rs1419247; rs17100141; rs17100143; rs17100758; rs1721160; rs17385707; rs17689089; rs1962523; rs2220835; rs2291689; rs2291690; rs2602930; rs2647511; rs35055337; rs35740293; rs4949787; rs4949812; rs4949813; rs6656443; rs6678173; rs6692366; rs728741; rs7552291

# Metabolic_Enzyme_113_General_References:
10215863

# Metabolic_Enzyme_113_References:
Not Available

# Metabolic_Enzyme_114_ID:
5925

# Metabolic_Enzyme_114_Name:
Selenide, water dikinase 1

# Metabolic_Enzyme_114_Synonyms:
Selenophosphate synthetase 1; Selenium donor protein 1

# Metabolic_Enzyme_114_Gene_Name:
SEPHS1

# Metabolic_Enzyme_114_Protein_Sequence:
>Selenide, water dikinase 1
MSTRESFNPESYELDKSFRLTRFTELKGTGCKVPQDVLQKLLESLQENHFQEDEQFLGAV
MPRLGIGMDTCVIPLRHGGLSLVQTTDYIYPIVDDPYMMGRIACANVLSDLYAMGVTECD
NMLMLLGVSNKMTDRERDKVMPLIIQGFKDAAEEAGTSVTGGQTVLNPWIVLGGVATTVC
QPNEFIMPDNAVPGDVLVLTKPLGTQVAVAVHQWLDIPEKWNKIKLVVTQEDVELAYQEA
MMNMARLNRTAAGLMHTFNAHAATDITGFGILGHAQNLAKQQRNEVSFVIHNLPVLAKMA
AVSKACGNMFGLMHGTCPETSGGLLICLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKG
NRTARIIDKPRIIEVAPQVATQNVNPTPGATS

# Metabolic_Enzyme_114_Number_of_Residues:
392

# Metabolic_Enzyme_114_Molecular_Weight:
42911

# Metabolic_Enzyme_114_Theoretical_pI:
5.84

# Metabolic_Enzyme_114_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  selenide, water dikinase activity
Function:  catalytic activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_114_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_114_Specific_Function:
Synthesizes selenophosphate from selenide and ATP

# Metabolic_Enzyme_114_Pathway:
map00450  Selenoamino acid metabolism

# Metabolic_Enzyme_114_Reaction:
ATP + selenide + H2O = AMP + selenophosphate + phosphate

# Metabolic_Enzyme_114_Pfam_Domain_Function:
PF00586:AIRS;
PF02769:AIRS_C

# Metabolic_Enzyme_114_Signals:
None

# Metabolic_Enzyme_114_Transmembrane_Regions:
None

# Metabolic_Enzyme_114_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_114_EC_Link:
EC 2.7.9.3

# Metabolic_Enzyme_114_GenBank_ID_Protein:
1000284

# Metabolic_Enzyme_114_SwissProt_ID:
SPS1_HUMAN (P49903)

# Metabolic_Enzyme_114_swissprot_Name:
Not Available

# Metabolic_Enzyme_114_Genecard_id:
SEPHS1

# Metabolic_Enzyme_114_Geneatlas_id:
SEPHS1

# Metabolic_Enzyme_114_hgnc_id:
HGNC:19685

# Metabolic_Enzyme_114_PDB_ID:
Not Available

# Metabolic_Enzyme_114_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_114_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_114_Subcellular_Location:
Not Available

# Metabolic_Enzyme_114_Gene_Sequence:
>1152 bp
ATGTCTACGCGGGAGTCCTTTAACCCGGAAAGTTACGAATTGGACAAAAGCTTCCGGCTA
ACCAGATTCACTGAACTGAAGGGCACAGGCTGCAAAGTGCCCCAAGATGTCCTGCAAAAA
TTGCTGGAATCTTTACAGGAGAACCACTTCCAAGAAGATGAGCAGTTTCTGGGAGCCGTT
ATGCCAAGGCTTGGCATTGGAATGGATACTTGTGTCATTCCTTTGAGGCACGGTGGGCTT
TCCTTGGTTCAAACCACAGATTACATTTACCCGATCGTAGACGACCCTTACATGATGGGC
AGGATAGCGTGTGCCAATGTCCTCAGTGACCTCTATGCAATGGGGGTCACGGAATGTGAC
AATATGCTGATGCTCCTTGGAGTCAGTAATAAAATGACCGACAGGGAAAGGGATAAAGTG
ATGCCTCTGATTATCCAAGGTTTTAAAGACGCAGCTGAGGAAGCAGGAACGTCTGTAACA
GGCGGCCAAACAGTACTAAACCCCTGGATTGTCCTGGGAGGAGTGGCTACCACTGTCTGC
CAACCCAATGAATTTATCATGCCAGACAATGCAGTGCCAGGGGACGTGCTGGTGCTGACA
AAACCCCTGGGGACACAGGTGGCAGTGGCTGTGCACCAGTGGCTGGATATCCCTGAGAAA
TGGAATAAGATTAAACTAGTGGTCACCCAAGAAGATGTAGAGCTGGCCTACCAGGAGGCG
ATGATGAACATGGCGAGGCTCAACAGGACAGCTGCAGGACTCATGCACACGTTCAATACC
CACGCCGCCACTGACATCACGGGCTTCGGGATTTTGGGCCATGCGCAGAACCTGGCCAAG
CAGCAGAGGAACGAGGTGTCGTTTGTAATTCACAACCTCCCGGTGCTGGCCAAGATGGCT
GCGGTGAGCAAGGCCTGCGGAAACATGTTCGGCCTCATGCACGGGACCTGCCCGGAGACT
TCAGGCGGCCTTCTGATCTGTTTACCACGTGAGCAAGCAGCTCGGTTCTGTGCAGAGATA
AAGTCCCCCAAATATGGTGAAGGCCACCAAGCATGGATTATTGGGATTGTAGAGAAGGGC
AACCGCACAGCCAGAATCATAGACAAACCCCGGATCATCGAGGTCGCACACAAGTGGCCA
CTCAAAACGTGA

# Metabolic_Enzyme_114_GenBank_ID_Gene:
U34044

# Metabolic_Enzyme_114_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_114_Locus:
10p14

# Metabolic_Enzyme_114_SNPs:
rs10752297; rs2275127; rs1005089; rs10752299; rs1556717; rs1004621; rs12569988; rs2254252; rs1747683; rs10508459; rs647253; rs2275129; rs10796060; rs10752296; rs7095230; rs2254154; rs7901303; rs7897851; rs2275128; rs3781087; rs2027167; rs7914142; rs10906347; rs10752294; rs1983830; rs10737069; rs3824655; rs6602648; rs10737070; rs2181839; rs17153117; rs3802584; rs7475361; rs10752298; rs4750346; rs1414399; rs10906348; rs3802583; rs7901525; rs11814895; rs11818582; rs7919509; rs17153110; rs2254157; rs7903477; rs3802582; rs11258334; rs10796059; rs9664303; rs17153104; rs7082928; rs3802585; rs10906352; rs10752295; rs10128408; rs10906353; rs11258325; rs3740211; rs7917549; rs584285; rs3781085; rs10906350; rs7918050; rs7894075; rs10796062; rs7916194; rs10906349; rs11595473; rs7100588; rs10737068; rs1547772; rs10796065; rs17153099; rs563564; rs2783648; rs11258324; rs1802843; rs7898477; rs28711667; rs7902331; rs2650; rs28649208; rs28410783; rs28422123; rs7901957; rs34626058; rs28451457; rs3864819; rs28756245; rs28670344; rs28682928; rs7901671; rs35862415; rs36108296; rs34242277; rs36072408; rs35387458; rs41291321; rs34648460; rs4475828; rs3215961; rs3802581; rs34658221; rs35446292; rs4278421; rs11816087; rs34027603; rs34774726; rs36025626; rs11258328; rs11258330; rs35535987; rs10552528; rs41291319; rs34933494; rs11258327; rs10546800; rs35582737; rs11258335; rs2001263; rs12247089; rs7902435; rs34946567; rs7919016; rs11818504; rs11258331; rs4474338; rs7083997; rs11258332; rs2265012; rs34250326; rs12265313; rs35635684; rs34167659; rs11258326; rs11591432; rs7095440; rs35840117; rs35374518; rs12255910; rs10128117; rs11258333; rs34788028; rs3802580; rs11258329; rs41302978; rs11345855; rs11442459; rs2253619; rs2253617; rs28742249; rs28468083; rs35249604; rs11430962; rs7088002; rs34467541; rs10752293; rs10796058; rs10906354; rs10906357; rs1095367; rs1095368; rs11258322; rs11258337; rs12765578; rs17529609; rs17602403; rs615497; rs7907912; rs7915089; rs7923713

# Metabolic_Enzyme_114_General_References:
7665581

# Metabolic_Enzyme_114_References:
Not Available

# Metabolic_Enzyme_115_ID:
5926

# Metabolic_Enzyme_115_Name:
Ubiquitin-conjugating enzyme E2 N

# Metabolic_Enzyme_115_Synonyms:
Ubiquitin-protein ligase N; Ubiquitin carrier protein N; Ubc13; Bendless-like ubiquitin-conjugating enzyme

# Metabolic_Enzyme_115_Gene_Name:
UBE2N

# Metabolic_Enzyme_115_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 
NMAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLP
EEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDD
PLANDVAEQWKTNEAQAIETARAWTRLYAMNNI

# Metabolic_Enzyme_115_Number_of_Residues:
152

# Metabolic_Enzyme_115_Molecular_Weight:
17138

# Metabolic_Enzyme_115_Theoretical_pI:
6.53

# Metabolic_Enzyme_115_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_115_General_Function:
Not Available

# Metabolic_Enzyme_115_Specific_Function:
The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys- 63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligase SHPRH in the poly- ubiquitination of PCNA 'Lys-164' upon genotoxic stress, which is required for DNA repair

# Metabolic_Enzyme_115_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_115_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_115_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_115_Signals:
None

# Metabolic_Enzyme_115_Transmembrane_Regions:
None

# Metabolic_Enzyme_115_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_115_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_115_GenBank_ID_Protein:
1181558

# Metabolic_Enzyme_115_SwissProt_ID:
UBE2N_HUMAN (P61088)

# Metabolic_Enzyme_115_swissprot_Name:
Not Available

# Metabolic_Enzyme_115_Genecard_id:
UBE2N

# Metabolic_Enzyme_115_Geneatlas_id:
UBE2N

# Metabolic_Enzyme_115_hgnc_id:
HGNC:12492

# Metabolic_Enzyme_115_PDB_ID:
1J7D

# Metabolic_Enzyme_115_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_115_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_115_Subcellular_Location:
Not Available

# Metabolic_Enzyme_115_Gene_Sequence:
>459 bp
ATGGCCGGGCTGCCCCGCAGGATCATCAAGGAAACCCAGCGTTTGCTGGCAGAACCAGTT
CCTGGCATCAAAGCCGAACCAGATGAGAGCAACGCCCGTTATTTTCATGTGGTCATTGCT
GGCCCTCAGGATTCCCCCTTTGAGGGAGGGACTTTTAAACTTGAACTATTCCTTCCAGAA
GAATACCCAATGGCAGCCCCTAAAGTACGTTTCATGACCAAAATTTATCATCCTAATGTA
GACAAGTTGGGAAGAATATGTTTAGATATTTTGAAAGATAAGTGGTCCCCAGCACTGCAG
ATCCGCACAGTTCTGCTATCGATCCAGGCCTTGTTAAGTGCTCCCAATCCAGATGATCCA
TTAGCAAATGATGTAGCGGAGCAGTGGAAGACCAACGAAGCCCAAGCCATAGAAACAGCT
AGAGCATGGACTAGGCTATATGCCATGAATAATATTTAA

# Metabolic_Enzyme_115_GenBank_ID_Gene:
D83004

# Metabolic_Enzyme_115_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_115_Locus:
12q22

# Metabolic_Enzyme_115_SNPs:
rs643247; rs1021136; rs7484825; rs7953247; rs12426990; rs7484824; rs7303325; rs7305670; rs7300607; rs7303274; rs7311222; rs11107025; rs11831401; rs17021218; rs17021226; rs17021223; rs17021220; rs1483003; rs2291266; rs4020454; rs7969431; rs7305153; rs17251787; rs12303259; rs11835441; rs11107020; rs7299705; rs11107024; rs7295796; rs11107018; rs4020453; rs12830302; rs6538418; rs17021224; rs7309933; rs12810300; rs11107022; rs11107017; rs7953721; rs12816436; rs7968453; rs3759169; rs3952508; rs7956793; rs12311641; rs11558876; rs13633; rs643258; rs35415779; rs11558877; rs34880795; rs11107016; rs11558873; rs574299; rs11558878; rs643636; rs11558874; rs34704075; rs11107021; rs34053448; rs641414; rs11833560; rs35091571; rs563966; rs7295360; rs607605; rs34525749; rs3782416; rs10437876; rs506911; rs531209; rs11107027; rs11835400; rs17021222; rs563933; rs607963; rs471862; rs35846559; rs664063; rs11107029; rs11835514; rs558419; rs35125903; rs657971; rs524497; rs35555714; rs4020452; rs563965; rs28641961; rs7303001; rs10459181; rs11107026; rs34720175; rs36018210; rs34530254; rs494999; rs7314146; rs35048677; rs34318510; rs11107028; rs35569740; rs35124423; rs3049603; rs11107023; rs524498; rs12809242; rs35343851; rs34065836; rs12821477; rs12312856; rs853669; rs10459180; rs10714261; rs34757750; rs12826404; rs1845371; rs596795; rs7132349; rs486398; rs35730071; rs7957305; rs7972279; rs12821933; rs34934936; rs7342330; rs12822459; rs12318501; rs12821957; rs7484994; rs535319; rs35097702; rs10859492; rs12597; rs12819043; rs35288079; rs668294; rs7306955; rs7962893; rs7973701; rs7973789

# Metabolic_Enzyme_115_General_References:
8902611; 10089880

# Metabolic_Enzyme_115_References:
Not Available

# Metabolic_Enzyme_116_ID:
5927

# Metabolic_Enzyme_116_Name:
cGMP-specific 3',5'-cyclic phosphodiesterase

# Metabolic_Enzyme_116_Synonyms:
CGB-PDE; cGMP-binding cGMP-specific phosphodiesterase

# Metabolic_Enzyme_116_Gene_Name:
PDE5A

# Metabolic_Enzyme_116_Protein_Sequence:
>cGMPspecific 3',5'cyclic phosphodiesterase
MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSVPGTPTRKISASEFDRPLRPIVVKDSEG
TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN

# Metabolic_Enzyme_116_Number_of_Residues:
875

# Metabolic_Enzyme_116_Molecular_Weight:
100014

# Metabolic_Enzyme_116_Theoretical_pI:
6.00

# Metabolic_Enzyme_116_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_116_General_Function:
Not Available

# Metabolic_Enzyme_116_Specific_Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP

# Metabolic_Enzyme_116_Pathway:
Not Available

# Metabolic_Enzyme_116_Reaction:
guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate

# Metabolic_Enzyme_116_Pfam_Domain_Function:
PF01590:GAF;
PF00233:PDEase_I

# Metabolic_Enzyme_116_Signals:
None

# Metabolic_Enzyme_116_Transmembrane_Regions:
None

# Metabolic_Enzyme_116_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_116_EC_Link:
EC 3.1.4.35

# Metabolic_Enzyme_116_GenBank_ID_Protein:
3420185

# Metabolic_Enzyme_116_SwissProt_ID:
PDE5A_HUMAN (O76074)

# Metabolic_Enzyme_116_swissprot_Name:
Not Available

# Metabolic_Enzyme_116_Genecard_id:
PDE5A

# Metabolic_Enzyme_116_Geneatlas_id:
PDE5A

# Metabolic_Enzyme_116_hgnc_id:
HGNC:8784

# Metabolic_Enzyme_116_PDB_ID:
Not Available

# Metabolic_Enzyme_116_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_116_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_116_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_116_Gene_Sequence:
>2628 bp
ATGGAGCGGGCCGGCCCCAGCTTCGGGCAGCAGCGACAGCAGCAGCAGCCCCAGCAGCAG
AAGCAGCAGCAGAGGGATCAGGACTCGGTCGAAGCATGGCTGGACGATCACTGGGACTTT
ACCTTCTCATACTTTGTTAGAAAAGCCACCAGAGAAATGGTCAATGCATGGTTTGCTGAG
AGAGTTCACACCATCCCTGTGTGCAAGGAAGGTATCAGAGGCCACACCGAATCTTGCTCT
TGTCCCTTGCAGCAGAGTCCTCGTGCAGATAACAGTGTCCCTGGAACACCAACCAGGAAA
ATCTCTGCCTCTGAATTTGACCGGCCTCTTAGACCCATTGTTGTCAAGGATTCTGAGGGA
ACTGTGAGCTTCCTCTCTGACTCAGAAAAGAAGGAACAGATGCCTCTAACCCCTCCAAGG
TTTGATCATGATGAAGGGGACCAGTGCTCAAGACTCTTGGAATTAGTGAAGGATATTTCT
AGTCATTTGGATGTCACAGCCTTATGTCACAAAATTTTCTTGCATATCCATGGACTGATA
TCTGCTGACCGCTATTCCCTGTTCCTTGTCTGTGAAGACAGCTCCAATGACAAGTTTCTT
ATCAGCCGCCTCTTTGATGTTGCTGAAGGTTCAACACTGGAAGAAGTTTCAAATAACTGT
ATCCGCTTAGAATGGAACAAAGGCATTGTGGGACATGTGGCAGCGCTTGGTGAGCCCTTG
AACATCAAAGATGCATATGAGGATCCTCGGTTCAATGCAGAAGTTGACCAAATTACAGGC
TACAAGACACAAAGCATTCTTTGTATGCCAATTAAGAATCATAGGGAAGAGGTTGTTGGT
GTAGCCCAGGCCATCAACAAGAAATCAGGAAACGGTGGGACATTTACTGAAAAAGATGAA
AAGGACTTTGCTGCTTATTTGGCATTTTGTGGTATTGTTCTTCATAATGCTCAGCTCTAT
GAGACTTCACTGCTGGAGAACAAGAGAAATCAGGTGCTGCTTGACCTTGCTAGTTTAATT
TTTGAAGAACAACAATCATTAGAAGTAATTTTGAAGAAAATAGCTGCCACTATTATCTCT
TTCATGCAAGTGCAGAAATGCACCATTTTCATAGTGGATGAAGATTGCTCCGATTCTTTT
TCTAGTGTGTTTCACATGGAGTGTGAGGAATTAGAAAAATCATCTGATACATTAACAAGG
GAACATGATGCAAACAAAATCAATTACATGTATGCTCAGTATGTCAAAAATACTATGGAA
CCACTTAATATCCCAGATGTCAGTAAGGATAAAAGATTTCCCTGGACAACTGAAAATACA
GGAAATGTAAACCAGCAGTGCATTAGAAGTTTGCTTTGTACACCTATAAAAAATGGAAAG
AAGAATAAAGTTATAGGGGTTTGCCAACTTGTTAATAAGATGGAGGAGAATACTGGCAAG
GTTAAGCCTTTCAACCGAAATGACGAACAGTTTCTGGAAGCTTTTGTCATCTTTTGTGGC
TTGGGGATCCAGAACACGCAGATGTATGAAGCAGTGGAGAGAGCCATGGCCAAGCAAATG
GTCACATTGGAGGTTCTGTCGTATCATGCTTCAGCAGCAGAGGAAGAAACAAGAGAGCTA
CAGTCGTTAGCGGCTGCTGTGGTGCCATCTGCCCAGACCCTTAAAATTACTGACTTTAGC
TTCAGTGACTTTGAGCTGTCTGATCTGGAAACAGCACTGTGTACAATTCGGATGTTTACT
GACCTCAACCTTGTGCAGAACTTCCAGATGAAACATGAGGTTCTTTGCAGATGGATTTTA
AGTGTTAAGAAGAATTATCGGAAGAATGTTGCCTATCATAATTGGAGACATGCCTTTAAT
ACAGCTCAGTGCATGTTTGCTGCTCTAAAAGCAGGCAAAATTCAGAACAAGCTGACTGAC
CTGGAGATACTTGCATTGCTGATTGCTGCACTAAGCCACGATTTGGATCACCGTGGTGTG
AATAACTCTTACATACAGCGAAGTGAACATCCACTTGCCCAGCTTTACTGCCATTCAATC
ATGGAACACCATCATTTTGACCAGTGCCTGATGATTCTTAATAGTCCAGGCAATCAGATT
CTCAGTGGCCTCTCCATTGAAGAATATAAGACCACGTTGAAAATAATCAAGCAAGCTATT
TTAGCTACAGACCTAGCACTGTACATTAAGAGGCGAGGAGAATTTTTTGAACTTATAAGA
AAAAATCAATTCAATTTGGAAGATCCTCATCAAAAGGAGTTGTTTTTGGCAATGCTGATG
ACAGCTTGTGATCTTTCTGCAATTACAAAACCCTGGCCTATTCAACAACGGATAGCAGAA
CTTGTAGCAACTGAATTTTTTGATCAAGGAGACAGAGAGAGAAAAGAACTCAACATAGAA
CCCACTGATCTAATGAACAGGGAGAAGAAAAACAAAATCCCAAGTATGCAAGTTGGGTTC
ATAGATGCCATCTGCTTGCAACTGTATGAGGCCCTGACCCACGTGTCAGAGGACTGTTTC
CCTTTGCTAGATGGCTGCAGAAAGAACAGGCAGAAATGGCAGGCCCTTGCAGAACAGCAG
GAGAAGATGCTGATTAATGGGGAAAGCGGCCAGGCCAAGCGGAACTGA

# Metabolic_Enzyme_116_GenBank_ID_Gene:
AF043731

# Metabolic_Enzyme_116_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_116_Locus:
4q25-q27

# Metabolic_Enzyme_116_SNPs:
rs3733526; rs17051276; rs11947234; rs6817975; rs4834789; rs10022664; rs4834790; rs4833622; rs6847164; rs17006190; rs7672961; rs6817738; rs10050092; rs4834788; rs6839165; rs4597811; rs11734241; rs6534146; rs11729521; rs11731568; rs13124532; rs4287988; rs2953294; rs6534145; rs2953293; rs3109370; rs12505735; rs4626181; rs6534147; rs1480938; rs28578366; rs12502511; rs11730798; rs6855918; rs6832740; rs17355550; rs8180147; rs28681016; rs7681796; rs6831062; rs1045177; rs2953290; rs4833620; rs2953295; rs2389885; rs4833621; rs17006236; rs7693919; rs7672519; rs6534148; rs13106925; rs28535956; rs1010740; rs2715021; rs2291185; rs1480939; rs2715018; rs1987179; rs1552095; rs1480940; rs1155576; rs1383532; rs2306456; rs2389869; rs1010739; rs3736115; rs7687843; rs7688802; rs2389866; rs3733523; rs11731756; rs11098531; rs12502423; rs11736416; rs12510138; rs12498599; rs11098532; rs3775844; rs3756157; rs7699064; rs2248236; rs12642735; rs13107334; rs3775847; rs12502389; rs2127822; rs3775854; rs9997631; rs10030660; rs3775852; rs12646525; rs2256645; rs1383533; rs10009626; rs7694856; rs2622499; rs2622500; rs10008791; rs4834779; rs1480933; rs13128602; rs3775845; rs6534140; rs6534139; rs10013305; rs1155577; rs2622496; rs2389868; rs7678400; rs2622497; rs2306455; rs3733520; rs1480936; rs6853998; rs2086450; rs13121569; rs10012485; rs13134665; rs3822191; rs7692994; rs12648259; rs2389863; rs3756156; rs2127823; rs11933966; rs10019674; rs3822194; rs10518333; rs3822192; rs7659250; rs10004484; rs11724055; rs3775856; rs2715020; rs10518336; rs3775848; rs7697823; rs10031665; rs3733525; rs3775843; rs10518335; rs6844263; rs7695620; rs10034450; rs10016736; rs3822190; rs3733524; rs3775858; rs7439678; rs3756155; rs17292047; rs13149407; rs7680748; rs7680063; rs7684899; rs3775846; rs17050695; rs12108288; rs17358524; rs11737395; rs17358860; rs9995026; rs4834784; rs13125819; rs7664986; rs4513554; rs3733521; rs3775850; rs1552092; rs11723090; rs2389864; rs2170276; rs13119104; rs3822193; rs3822195; rs7670921; rs10031483; rs3756154; rs10434031; rs2257018; rs6858592; rs7658561; rs3775851; rs3733519; rs4834787; rs6847818; rs6843229; rs2928991; rs7441716; rs10032392; rs10471013; rs6835635; rs34676199; rs6842674; rs17007201; rs4146266; rs10023384; rs4834786; rs10003953; rs13104219; rs11936555; rs2892869; rs7662636; rs6858777; rs6822275; rs13120581; rs10029882; rs2389867; rs11936841; rs7657515; rs17357499; rs12503853; rs11942898; rs6845402; rs3836705; rs9998919; rs17050700; rs10027735; rs9762527; rs10021460; rs4001175; rs2953292; rs2127827; rs12503809; rs12503898; rs7657849; rs17357002; rs3775842; rs10032993; rs9307478; rs2306457; rs1552094; rs3832310; rs11728616; rs2389870; rs10018280; rs10031328; rs17358475; rs3775841; rs6833334; rs12648182; rs17007576; rs17051261; rs1480934; rs2892867; rs2127826; rs10021823; rs12498539; rs13103899; rs6834347; rs9884402; rs4264816; rs2715022; rs11098533; rs17051262; rs6534141; rs6829903; rs2389865; rs9997423; rs12502531; rs17007472; rs7669520; rs2389871; rs3806808; rs17005698; rs6834796; rs13116789; rs35062994; rs2389884; rs11363700; rs10025536; rs13136462; rs35938775; rs8180145; rs10615829; rs28566610; rs10021469; rs28419430; rs9992502; rs11290659; rs35004652; rs6817317; rs13118388; rs13122502; rs5861435; rs7681980; rs10711029; rs35748413; rs35455771; rs13136296; rs35454723; rs34901236; rs35101570; rs34918444; rs12504983; rs28469881; rs34601943; rs1045157; rs35758637; rs11324618; rs35620864; rs28450144; rs35105657; rs35566617; rs35184157; rs34269739; rs34089664; rs3839163; rs33918643; rs34202789; rs12648652; rs28415331; rs10536068; rs11453574; rs35081967; rs10155235; rs35432148; rs35967840; rs35674158; rs9307480; rs11334790; rs10013852; rs3056860; rs3056797; rs5861432; rs11295209; rs10706998; rs34945097; rs35264119; rs13140497; rs11352066; rs34521874; rs3775849; rs35182804; rs13140391; rs35189456; rs28736368; rs36026032; rs3775855; rs11392885; rs35576199; rs3832309; rs4337718; rs35999787; rs33952829; rs3836709; rs2928994; rs33963018; rs11343673; rs34825792; rs28405434; rs28625289; rs36170021; rs5861429; rs10021318; rs10213498; rs35236680; rs35535411; rs35412284; rs9884290; rs12331661; rs2715015; rs34712759; rs34873286; rs5861431; rs11455919; rs2928995; rs34978491; rs28576329; rs35960124; rs35111518; rs3733522; rs35852479; rs10031926; rs10213673; rs36173322; rs28735358; rs13115778; rs33940010; rs28375929; rs13147578; rs35409170; rs41278071; rs34944084; rs36046509; rs36159601; rs11931723; rs13137511; rs7692325; rs34830431; rs34698887; rs41464847; rs28540362; rs4834783; rs28718422; rs35777352; rs35289699; rs7685157; rs34868248; rs34368241; rs10010096; rs35906047; rs5861433; rs5861434; rs34847681; rs2928992; rs7694813; rs36137103; rs28621505; rs34160653; rs10015714; rs35201113; rs34036667; rs12505618; rs33944872; rs4834782; rs12108603; rs28394116; rs12331968; rs28382361; rs12508098; rs33926198; rs7678973; rs11299247; rs12644001; rs35813548; rs11438089; rs28639494; rs13103510; rs10697082; rs13133969; rs4340778; rs35507637; rs2928993; rs34492508; rs2622501; rs2715019; rs34840968; rs35233299; rs28394320; rs17291073; rs10696044; rs10710194; rs28380652; rs35466933; rs28634062; rs35172283; rs6854072; rs28461667; rs13152138; rs10612127; rs33935566; rs3836706; rs35865360; rs35632964; rs2715016; rs11945344; rs35852065; rs36191671; rs10434030; rs34294229; rs10696018; rs9994195; rs34146690; rs9998244; rs33937429; rs3214947; rs34463475; rs33977085; rs41278067; rs35791145; rs3836707; rs34025740; rs36108275; rs34504999; rs4604044; rs4001176; rs35326039; rs2622495; rs7691391; rs34308924; rs28412979; rs28622960; rs28685688; rs34772207; rs35595874; rs36040693; rs36192830; rs34426121; rs11945339; rs34892273; rs34255091; rs13140409; rs28650385; rs2622498; rs35519053; rs34129926; rs10640351; rs9998095; rs9996803; rs10579225; rs10545059; rs34002300; rs34244089; rs35539932; rs13140150; rs2306458; rs9884862; rs34767405; rs3836710; rs35108769; rs17356245; rs36197915; rs36098810; rs2622503; rs4998488; rs5861430; rs34123358; rs35850447; rs34580725; rs3836708; rs35609470; rs34953413; rs28564258; rs4596225; rs2928996; rs2622502; rs33998714; rs13137618; rs33944547; rs722667; rs35361251; rs34473068; rs35151809; rs10028249; rs10641710; rs41278069; rs2892868; rs11289914; rs10003668; rs34910273; rs28678287; rs34575312; rs34309305; rs11356355; rs11269159; rs33990318; rs28590372; rs34347414; rs11297755; rs35585470; rs35298888; rs36195333; rs34672540; rs28626938; rs9307477; rs28372207; rs34804498; rs4146268; rs722668; rs1552093; rs11551967; rs36196342; rs1480935; rs10010097; rs12649367; rs5020222; rs34009787; rs34884781; rs33993326; rs36194561; rs28615474; rs34736985; rs11408932; rs3840504; rs33930936; rs34480487; rs33982542; rs11342908; rs13149629; rs28653590; rs2953291; rs35952089; rs10643383; rs10639733; rs11344214; rs35833768; rs10006525; rs10006706; rs10009566; rs10017842; rs11098530; rs11935596; rs11940028; rs11940549; rs12507964; rs12508504; rs13145352; rs2389878; rs4834792; rs6849171; rs6849561; rs7675276; rs7681544

# Metabolic_Enzyme_116_General_References:
9714779; 9716380; 9642111; 10393044; 12955149

# Metabolic_Enzyme_116_References:
Not Available

# Metabolic_Enzyme_117_ID:
5928

# Metabolic_Enzyme_117_Name:
Argininosuccinate synthase

# Metabolic_Enzyme_117_Synonyms:
Citrulline--aspartate ligase

# Metabolic_Enzyme_117_Gene_Name:
ASS1

# Metabolic_Enzyme_117_Protein_Sequence:
>Argininosuccinate synthase
MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVF
IEDVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATG
KGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWS
MDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKD
GTTHQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAF
TMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVLKGQVYI
LGRESPLSLYNEELVSMNVQGDYEPTDATGFININSLRLKEYHRLQSKVTAK

# Metabolic_Enzyme_117_Number_of_Residues:
412

# Metabolic_Enzyme_117_Molecular_Weight:
46531

# Metabolic_Enzyme_117_Theoretical_pI:
8.18

# Metabolic_Enzyme_117_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  argininosuccinate synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  urea cycle intermediate metabolism
Process:  arginine metabolism
Process:  arginine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_117_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_117_Specific_Function:
ATP + L-citrulline + L-aspartate = AMP + diphosphate + omega-N-(L-arginino)succinate

# Metabolic_Enzyme_117_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00252  Alanine and aspartate metabolism;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_117_Reaction:
ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate

# Metabolic_Enzyme_117_Pfam_Domain_Function:
PF00764:Arginosuc_synth

# Metabolic_Enzyme_117_Signals:
None

# Metabolic_Enzyme_117_Transmembrane_Regions:
None

# Metabolic_Enzyme_117_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_117_EC_Link:
EC 6.3.4.5

# Metabolic_Enzyme_117_GenBank_ID_Protein:
28872

# Metabolic_Enzyme_117_SwissProt_ID:
ASSY_HUMAN (P00966)

# Metabolic_Enzyme_117_swissprot_Name:
Not Available

# Metabolic_Enzyme_117_Genecard_id:
ASS1

# Metabolic_Enzyme_117_Geneatlas_id:
ASS1

# Metabolic_Enzyme_117_hgnc_id:
HGNC:758

# Metabolic_Enzyme_117_PDB_ID:
Not Available

# Metabolic_Enzyme_117_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_117_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_117_Subcellular_Location:
Not Available

# Metabolic_Enzyme_117_Gene_Sequence:
>1239 bp
ATGTCCAGCAAAGGCTCCGTGGTTCTGGCCTACAGTGGCGGCCTGGACACCTCGTGCATC
CTCGTGTGGCTGAAGGAACAAGGCTATGACGTCATTGCCTATCTGGCCAACATTGGCCAG
AAGGAAGACTTCGAGGAAGCCAGGAAGAAGGCACTGAAGCTTGGGGCCAAAAAGGTGTTC
ATTGAGGATGTCAGCAGGGAGTTTGTGGAGGAGTTCATCTGGCCGGCCATCCAGTCCAGC
GCACTGTATGAGGACCGCTACCTCCTGGGCACCTCTCTTGCCAGGCCCTGCATCGCCCGC
AAACAAGTGGAAATCGCCCAGCGGGAGGGGGCCAAGTATGTGTCCCACGGCGCCACAGGA
AAGGGGAACGATCAGGTCCGGTTTGAGCTCAGCTGCTACTCACTGGCCCCCCAGATAAAG
GTCATTGCTCCCTGGAGGATGCCTGAATTCTACAACCGGTTCAAGGGCCGCAATGACCTG
ATGGAGTACGCAAAGCAACACGGGATTCCCATCCCGGTCACTCCCAAGAACCCGTGGAGC
ATGGATGAGAACCTCATGCACATCAGCTACGAGGCTGGAATCCTGGAGAACCCCAAGAAC
CAAGCGCCTCCAGGTCTCTACACGAAGACCCAGGACCCAGCCAAAGCCCCCAACACCCCT
GACATTCTCGAGATCGAGTTCAAAAAAGGGGTCCCTGTGAAGGTGACCAACGTCAAGGAT
GGCACCACCCACCAGACCTCCTTGGAGCTCTTCATGTACCTGAACGAAGTCGCGGGCAAG
CATGGCGTGGGCCGTATTGACATCGTGGAGAACCGCTTCATTGGAATGAAGTCCCGAGGT
ATCTACGAGACCCCAGCAGGCACCATCCTTTACCATGCTCATTTAGACATCGAGGCCTTC
ACCATGGACCGGGAAGTGCGCAAAATCAAACAAGGCCTGGGCTTGAAATTTGCTGAGCTG
GTGTATACCGGTTTACGGCCTAGCCCTGAGTGTGAATTTGTCCGCCACTGCATCGCCAAG
TCCCAGGAGCGAGTGGAAGGGAAAGTGCAGGTGTCCGTCCTCAAGGGCCAGGTGTACATC
CTCGGCCGGGAGTCCCCACTGTCTCTCTACAATGAGGAGCTGGTGAGCATGAACGTGCAG
GGTGATTATGAGCCAACTGATGCCACCGGGTTCATCAACATCAATTCCCTCAGGCTGAAG
GAATATCATCGTCTCCAGAGCAAGGTCACTGCCAAATAG

# Metabolic_Enzyme_117_GenBank_ID_Gene:
X01630

# Metabolic_Enzyme_117_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_117_Locus:
9q34.1

# Metabolic_Enzyme_117_SNPs:
rs10901072; rs877326; rs4740158; rs6597680; rs7040665; rs11243372; rs12554609; rs12004384; rs10901047; rs914983; rs12380009; rs4740435; rs10121847; rs7042129; rs10123082; rs1760275; rs11244382; rs12685110; rs474330; rs553696; rs596317; rs506705; rs602924; rs504752; rs1215983; rs6597499; rs1215971; rs1215980; rs493389; rs543048; rs1215984; rs634432; rs666174; rs914971; rs1215970; rs1653332; rs10901080; rs590086; rs1215979; rs502901; rs666971; rs1215985; rs1215990; rs12555797; rs554629; rs7860909; rs3780588; rs1215986; rs12005118; rs1215972; rs7036163; rs2043189; rs2282219; rs914970; rs480313; rs1215988; rs12551145; rs17147029; rs2991273; rs12375699; rs641510; rs486889; rs7018779; rs17147023; rs506626; rs1215981; rs10114424; rs544701; rs618504; rs11243414; rs4322051; rs548262; rs1615006; rs11789315; rs1215982; rs12340606; rs529569; rs17147021; rs507351; rs1215991; rs7039110; rs7851267; rs1864708; rs1619401; rs652313; rs502166; rs10122141; rs668738; rs476067; rs2043191; rs10901085; rs580228; rs1215978; rs2043190; rs12003032; rs12553162; rs17147018; rs1215940; rs566037; rs640181; rs7847222; rs12000999; rs1760253; rs12343715; rs1215975; rs11243474; rs12377651; rs1215987; rs7040689; rs1215976; rs584157; rs4032; rs540140; rs4740430; rs928518; rs7854616; rs688430; rs35269064; rs11549769; rs1057484; rs35772983; rs3208841; rs2297599; rs13440219; rs13290196; rs35463800; rs11243377; rs12685093; rs3012668; rs35902422; rs5900898; rs11272909; rs3085579; rs10121464; rs28534724; rs11337242; rs28511880; rs13293193; rs35000413; rs5900899; rs12340634; rs41296095; rs35487019; rs1215977; rs35835384; rs34768057; rs3780589; rs34339017; rs11243481; rs34029710; rs34271203; rs11271310; rs11243542; rs13301636; rs12171726; rs34273046; rs4740317; rs35512453; rs1653340; rs34362653; rs34654848; rs1653334; rs11243500; rs35852270; rs12376592; rs35568745; rs12343078; rs11243395; rs28440121; rs34248043; rs12378416; rs1215941; rs12375712; rs28665572; rs11243405; rs35797527; rs4740239; rs2313201; rs884804; rs3030699; rs34037515; rs35769425; rs34790521; rs1215989; rs35976100; rs35015356; rs2297598; rs10114733; rs6151195; rs41302903; rs928517; rs12344308; rs2915535; rs28634784; rs35889473; rs884803; rs35476109; rs34850609; rs596698; rs13288900; rs34421800; rs35943966; rs534737; rs28530182; rs2116393; rs11243400; rs35581111; rs12553789; rs28633982; rs4740161; rs34599158; rs35204727; rs631908; rs13288740; rs7025952; rs1467802; rs11788148; rs35842179; rs11243523; rs11243545; rs7030804; rs34149601; rs7855232; rs35220375; rs28587006; rs11244367; rs12352216; rs11244364; rs7043097; rs34734822; rs36233815; rs2071367; rs35688375; rs10793902; rs10901110; rs11244343; rs12236605; rs12337532; rs12342208; rs12345660; rs2313079; rs3087691; rs4237122; rs7041914; rs7851772; rs7865294; rs7869828; rs928516

# Metabolic_Enzyme_117_General_References:
6194510; 6321498; 11941481; 2788888; 9150948; 2358466; 1943692; 7977368; 8792870; 11708871; 12815590

# Metabolic_Enzyme_117_References:
Not Available

# Metabolic_Enzyme_118_ID:
5929

# Metabolic_Enzyme_118_Name:
AMP deaminase 1

# Metabolic_Enzyme_118_Synonyms:
Myoadenylate deaminase; AMP deaminase isoform M

# Metabolic_Enzyme_118_Gene_Name:
AMPD1

# Metabolic_Enzyme_118_Protein_Sequence:
>AMP deaminase 1
MPLFKLPAEEKQIDDAMRNFAEKVFASEVKDEGGRQEISPFDVDEICPISHHEMQAHIFH
LETLSTSTEARRKKRFQGRKTVNLSIPLSETSSTKLSHIDEYISSSPTYQTVPDFQRVQI
TGDYASGVTVEDFEIVCKGLYRALCIREKYMQKSFQRFPKTPSKYLRNIDGEAWVANESF
YPVFTPPVKKGEDPFRTDNLPENLGYHLKMKDGVVYVYPNEAAVSKDEPKPLPYPNLDTF
LDDMNFLLALIAQGPVKTYTHRRLKFLSSKFQVHQMLNEMDELKELKNNPHRDFYNCRKV
DTHIHAAACMNQKHLLRFIKKSYQIDADRVVYSTKEKNLTLKELFAKLKMHPYDLTVDSL
DVHAGRQTFQRFDKFNDKYNPVGASELRDLYLKTDNYINGEYFATIIKEVGADLVEAKYQ
HAEPRLSIYGRSPDEWSKLSSWFVCNRIHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLE
NIFMPVFEATINPQADPELSVFLKHITGFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPS
YTYYAYYMYANIMVLNSLRKERGMNTFLFRPHCGEAGALTHLMTAFMIADDISHGLNLKK
SPVLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEP
LMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKVKFLGDNYLEEGPAGNDIRRTNV
AQIRMAYRYETWCYELNLIAEGLKSTE

# Metabolic_Enzyme_118_Number_of_Residues:
747

# Metabolic_Enzyme_118_Molecular_Weight:
86491

# Metabolic_Enzyme_118_Theoretical_pI:
6.89

# Metabolic_Enzyme_118_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  AMP deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_118_General_Function:
Not Available

# Metabolic_Enzyme_118_Specific_Function:
AMP deaminase plays a critical role in energy metabolism

# Metabolic_Enzyme_118_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_118_Reaction:
AMP + H2O = IMP + ammonia

# Metabolic_Enzyme_118_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_118_Signals:
None

# Metabolic_Enzyme_118_Transmembrane_Regions:
None

# Metabolic_Enzyme_118_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_118_EC_Link:
EC 3.5.4.6

# Metabolic_Enzyme_118_GenBank_ID_Protein:
10864686

# Metabolic_Enzyme_118_SwissProt_ID:
AMPD1_HUMAN (P23109)

# Metabolic_Enzyme_118_swissprot_Name:
Not Available

# Metabolic_Enzyme_118_Genecard_id:
AMPD1

# Metabolic_Enzyme_118_Geneatlas_id:
AMPD1

# Metabolic_Enzyme_118_hgnc_id:
HGNC:468

# Metabolic_Enzyme_118_PDB_ID:
Not Available

# Metabolic_Enzyme_118_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_118_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_118_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_118_Gene_Sequence:
>2244 bp
ATGCCTCTGTTCAAACTCCCAGCTGAAGAGAAACAAATTGATGATGCAATGCGCAACTTT
GCTGAAAAAGTGTTTGCCTCTGAAGTCAAAGATGAAGGAGGTCGTCAGGAGATTTCCCCC
TTTGATGTGGATGAGATCTGTCCGATTTCTCATCATGAGATGCAAGCACACATATTCCAT
CTGGAGACTCTGTCCACCTCCACAGAAGCCAGGAGAAAAAAGCGTTTCCAAGGACGGAAG
ACTGTTAATTTGTCCATTCCACTAAGTGAAACATCTTCCACCAAACTGTCCCACATTGAT
GAATACATTTCCTCATCTCCAACCTACCAGACCGTGCCTGATTTTCAGAGAGTGCAGATT
ACTGGTGACTATGCCTCTGGGGTTACAGTTGAAGATTTTGAAATTGTTTGCAAAGGTCTG
TATCGGGCACTATGCATACGTGAGAAATACATGCAGAAGTCGTTTCAGAGGTTCCCTAAA
ACCCCTTCCAAATACTTGCGGAACATTGATGGTGAGGCTTGGGTAGCAAATGAGAGCTTC
TATCCAGTCTTTACTCCTCCTGTGAAGAAGGGAGAGGACCCCTTCCGAACAGACAACCTT
CCTGAAAACCTGGGCTATCACCTCAAAATGAAGGACGGTGTAGTTTACGTCTATCCTAAT
GAAGCAGCAGTCAGCAAAGATGAGCCTAAGCCACTTCCTTACCCAAATCTGGACACCTTC
TTAGACGATATGAATTTTTTACTTGCTTTAATTGCTCAAGGACCTGTTAAGACCTATACC
CACCGGCGCCTGAAGTTCCTCTCCTCGAAGTTCCAGGTCCATCAGATGCTTAACGAGATG
GACGAGTTAAAGGAGCTGAAAAACAACCCCCACCGAGATTTTTATAACTGCAGGAAGGTG
GACACCCATATCCATGCAGCCGCTTGCATGAACCAGAAACATCTGCTGCGTTTTATTAAG
AAATCTTACCAAATTGATGCTGACAGAGTGGTCTATAGCACCAAAGAGAAGAATCTGACC
CTAAAGGAACTTTTTGCTAAATTAAAAATGCATCCTTATGACCTGACTGTTGATTCTCTG
GATGTTCATGCTGGACGCCAGACCTTCCAGCGTTTTGATAAGTTCAATGACAAATATAAT
CCTGTAGGAGCAAGTGAGCTACGGGACCTCTACTTGAAGACAGACAATTACATTAATGGG
GAATATTTTGCCACTATCATCAAGGAGGTAGGTGCGGACCTGGTGGAGGCCAAGTACCAG
CATGCTGAGCCCCGCCTGTCCATCTATGGCCGCAGTCCTGATGAGTGGAGCAAACTCTCC
TCCTGGTTCGTCTGCAATCGCATCCACTGCCCCAACATGACATGGATGATCCAGGTTCCC
AGGATCTATGATGTGTTCCGTTCCAAGAATTTCCTTCCACATTTTGGAAAAATGCTGGAG
AATATTTTCATGCCAGTGTTTGAGGCCACCATCAACCCCCAGGCTGACCCAGAACTCAGT
GTCTTCCTCAAGCATATCACTGGCTTTGACAGTGTGGATGATGAGTCCAAACACAGTGGC
CACATGTTCTCCTCCAAGAGTCCCAAGCCCCAGGAGTGGACATTGGAAAAGAATCCATCT
TACACTTACTATGCCTACTACATGTATGCAAACATCATGGTGCTCAACAGCCTGAGAAAG
GAACGAGGCATGAATACGTTTCTGTTCCGACCTCACTGTGGAGAAGCTGGAGCCCTCACC
CATCTCATGACAGCATTCATGATAGCAGATGATATCTCTCATGGCCTAAATTTAAAAAAG
AGTCCCGTGCTACAGTACTTGTTTTTCTTAGCCCAAATTCCCATCGCCATGTCACCACTA
AGTAACAATAGCCTATTTCTAGAGTATGCCAAAAATCCTTTTTTGGATTTCCTTCAGAAA
GGGCTAATGATCTCACTGTCTACAGATGACCCAATGCAATTCCACTTTACCAAGGAGCCC
CTAATGGAAGAATATGCTATTGCTGCACAAGTCTTCAAGCTGAGCACCTGTGATATGTGC
GAAGTGGCAAGGAACAGTGTCTTGCAGTGTGGAATTTCTCATGAGGAGAAAGTAAAGTTT
CTGGGCGACAATTACCTTGAGGAAGGCCCTGCTGGAAATGATATCCGGAGGACAAATGTA
GCCCAAATCCGCATGGCCTATCGCTATGAAACCTGGTGTTATGAACTCAATTTAATTGCT
GAGGGTCTTAAATCAACAGAATAA

# Metabolic_Enzyme_118_GenBank_ID_Gene:
M37931

# Metabolic_Enzyme_118_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_118_Locus:
1p13

# Metabolic_Enzyme_118_SNPs:
rs17602729; rs12566550; rs2268697; rs2010899; rs2268701; rs2336363; rs761755; rs2268700; rs2268699; rs2070986; rs743041; rs6679869; rs7531877; rs12407408; rs6683173; rs1884296; rs2268698; rs3789627; rs7515356; rs11585780; rs17032832; rs6678312; rs11102831; rs11589112; rs6697362; rs12132598; rs6663302; rs12038990; rs2268696; rs11588144; rs926938; rs6667218; rs34526199; rs35859650; rs2273268; rs34778674; rs34287100; rs949421; rs35197706; rs34257411; rs12096667; rs11451311; rs34245099; rs7518060; rs35468504; rs10698057; rs35746234; rs34418559; rs34741374; rs34355177; rs10601370; rs33984400; rs7541903; rs35241478; rs6656110; rs34630625; rs12036263; rs35985810; rs6685096; rs11412027; rs7543893; rs12354159; rs10645732; rs10611520; rs6701394; rs6701427; rs915955; rs737549; rs34909498; rs35027577; rs6697757; rs10776787; rs11577646; rs11587596; rs11799831; rs11801474; rs11803022; rs12564817; rs12753208; rs17032822; rs4537551; rs4839014; rs6537843; rs6695699; rs7516111

# Metabolic_Enzyme_118_General_References:
2345176; 1370861; 1631143; 11102975

# Metabolic_Enzyme_118_References:
Not Available

# Metabolic_Enzyme_119_ID:
5314

# Metabolic_Enzyme_119_Name:
Soluble calcium-activated nucleotidase 1

# Metabolic_Enzyme_119_Synonyms:
SCAN-1; Apyrase homolog; Putative NF-kappa-B-activating protein 107; Putative MAPK-activating protein PM09

# Metabolic_Enzyme_119_Gene_Name:
CANT1

# Metabolic_Enzyme_119_Protein_Sequence:
>Soluble calciumactivated nucleotidase 1
MPVQLSEHPEWNESMHSLRISVGGLPVLASMTKAADPRFRPRWKVILTFFVGAAILWLLC
SHRPAPGRPPTHNAHNWRLGQAPANWYNDTYPLSPPQRTPAGIRYRIAVIADLDTESRAQ
EENTWFSYLKKGYLTLSDSGDKVAVEWDKDHGVLESHLAEKGRGMELSDLIVFNGKLYSV
DDRTGVVYQIEGSKAVPWVILSDGDGTVEKGFKAEWLAVKDERLYVGGLGKEWTTTTGDV
VNENPEWVKVVGYKGSVDHENWVSNYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPR
RASQERYSEKDDERKGANLLLSASPDFGDIAVSHVGAVVPTHGFSSFKFIPNTDDQIIVA
LKSEEDSGRVASYIMAFTLDGRFLLPETKIGSVKYEGIEFI

# Metabolic_Enzyme_119_Number_of_Residues:
401

# Metabolic_Enzyme_119_Molecular_Weight:
44840

# Metabolic_Enzyme_119_Theoretical_pI:
5.98

# Metabolic_Enzyme_119_GO_Classification:
Not Available

# Metabolic_Enzyme_119_General_Function:
Not Available

# Metabolic_Enzyme_119_Specific_Function:
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP

# Metabolic_Enzyme_119_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_119_Reaction:
A nucleoside diphosphate + H2O = a nucleotide + phosphate

# Metabolic_Enzyme_119_Pfam_Domain_Function:
PF06079:Apyrase

# Metabolic_Enzyme_119_Signals:
None

# Metabolic_Enzyme_119_Transmembrane_Regions:
45-62

# Metabolic_Enzyme_119_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_119_EC_Link:
EC 3.6.1.6

# Metabolic_Enzyme_119_GenBank_ID_Protein:
22218108

# Metabolic_Enzyme_119_SwissProt_ID:
CANT1_HUMAN (Q8WVQ1)

# Metabolic_Enzyme_119_swissprot_Name:
Not Available

# Metabolic_Enzyme_119_Genecard_id:
CANT1

# Metabolic_Enzyme_119_Geneatlas_id:
CANT1

# Metabolic_Enzyme_119_hgnc_id:
HGNC:19721

# Metabolic_Enzyme_119_PDB_ID:
1S1D

# Metabolic_Enzyme_119_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_119_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_119_Subcellular_Location:
Intracytoplasmic membrane; single-pass type II membrane protein. Processed form:Secreted protein

# Metabolic_Enzyme_119_Gene_Sequence:
>1116 bp
ATGACCAAGGCCGCGGACCCCCGCTTCCGCCCCCGCTGGAAGGTGATCCTGACGTTCTTT
GTGGGTGCTGCCATCCTCTGGCTGCTCTGCTCCCACCGCCCGGCCCCCGGCAGGCCCCCC
ACCCACAATGCACACAACTGGAGGCTCGGCCAGGCGCCCGCCAACTGGTACAATGACACC
TACCCCCTGTCTCCCCCACAAAGGACACCGGCTGGGATTCGGTATCGAATCGCAGTTATC
GCAGACCTGGACACAGAGTCAAGGGCCCAAGAGGAAAACACCTGGTTCAGTTACCTGAAA
AAGGGCTACCTGACCCTGTCAGACAGTGGGGACAAGGTGGCCGTGGAATGGGACAAAGAC
CATGGGGTCCTGGAGTCCCACCTGGCGGAGAAGGGGAGAGGCATGGAGCTATCCGACCTG
ATTGTTTTCAATGGGAAACTCTACTCCGTGGATGACCGGACGGGGGTCGTCTACCAGATC
GAAGGCAGCAAAGCCGTGCCCTGGGTGATTCTGTCCGACGGCGACGGCACCGTGGAGAAA
GGCTTCAAGGCCGAATGGCTGGCAGTGAAGGACGAGCGTCTGTACGTGGGCGGCCTGGGC
AAGGAGTGGACGACCACTACGGGTGATGTGGTGAACGAGAACCCGGAGTGGGTGAAGGTG
GTGGGCTACAAGGGCAGCGTGGACCACGAGAACTGGGTGTCCAACTACAACGCCCTGCGG
GCTGCTGCCGGCATCCAGCCGCCAGGCTACCTCATCCATGAGTCTGCCTGCTGGAGTGAC
ACGCTGCAGCGCTGGTTCTTCCTGCCGCGCCGCGCCAGCCAGGAGCGCTACAGCGAGAAG
GACGACGAGCGCAAGGGCGCCAACCTGCTGCTGAGCGCCTCCCCTGACTTCGGCGACATC
GCTGTGAGCCACGTCGGGGCGGTGGTCCCCACTCACGGCTTCTCGTCCTTCAAGTTCATC
CCCAACACCGACGACCAGATCATTGTGGCCCTCAAATCCGAGGAGGACAGCGGCAGAGTC
GCCTCCTACATCATGGCCTTCACGCTGGACGGGCGCTTCCTGTTGCCGGAGACCAAGATC
GGAAGCGTGAAATACGAAGGCATCGAGTTCATTTAA

# Metabolic_Enzyme_119_GenBank_ID_Gene:
AF328554

# Metabolic_Enzyme_119_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_119_Locus:
17q25.3

# Metabolic_Enzyme_119_SNPs:
rs8077024; rs35290882; rs35324359; rs2377301; rs9916285; rs3744171; rs4789903; rs9896857; rs4789848; rs12450407; rs7214331; rs12450128; rs4789847; rs4861; rs11891; rs17739056; rs12452918; rs3744173; rs12949479; rs16971940; rs8079368; rs4789904; rs9904301; rs3744170; rs12452876; rs3744168; rs9915230; rs12452980; rs12451303; rs11546278; rs34082669; rs9903215; rs3803781; rs1127654; rs34461224; rs2377010; rs5017245; rs34435616; rs5017244; rs35308608; rs35755919; rs7219932; rs28627413; rs8078860; rs34996994; rs12936828; rs9899883; rs35356398; rs34938499; rs5017243; rs34572362; rs14791; rs4789849; rs34891215; rs2377009; rs34097366; rs35738150; rs5017242; rs3038740; rs35518955; rs9891726; rs3744169; rs12939358; rs12939350; rs12939399; rs4497730; rs6501274; rs9914188

# Metabolic_Enzyme_119_General_References:
12234496; 12761501; 12167635

# Metabolic_Enzyme_119_References:
Not Available

# Metabolic_Enzyme_120_ID:
5506

# Metabolic_Enzyme_120_Name:
Phenylalanyl-tRNA synthetase alpha chain

# Metabolic_Enzyme_120_Synonyms:
Phenylalanine--tRNA ligase alpha chain; PheRS; CML33

# Metabolic_Enzyme_120_Gene_Name:
FARSA

# Metabolic_Enzyme_120_Protein_Sequence:
>PhenylalanyltRNA synthetase alpha chain
MADGQVAELLLRRLEASDGGLDSAELAAELGMEHQAVVGAVKSLQALGEVIEAELRSTKH
WELTAEGEEIAREGSHEARVFRSIPPEGLAQSELMRLPSGKVGFSKAMSNKWIRVDKSAA
DGPRVFRVVDSMEDEVQRRLQLVRGGQAEKLGEKERSELRKRKLLAEVTLKTYWVSKGSA
FSTSISKQETELSPEMISSGSWRDRPFKPYNFLAHGVLPDSGHLHPLLKVRSQFRQIFLE
MGFTEMPTDNFIESSFWNFDALFQPQQHPARDQHDTFFLRDPAEALQLPMDYVQRVKRTH
SQGGYGSQGYKYNWKLDEARKNLLRTHTTSASARALYRLAQKKPFTPVKYFSIDRVFRNE
TLDATHLAEFHQIEGVVADHGLTLGHLMGVLREFFTKLGITQLRFKPAYNPYTEPSMEVF
SYHQGLKKWVEVGNSGVFRPEMLLPMGLPENVSVIAWGLSLERPTMIKYGINNIRELVGH
KVNLQMVYDSPLCRLDAEPRPPPTQEAA

# Metabolic_Enzyme_120_Number_of_Residues:
508

# Metabolic_Enzyme_120_Molecular_Weight:
57564

# Metabolic_Enzyme_120_Theoretical_pI:
7.96

# Metabolic_Enzyme_120_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  phenylalanine-tRNA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  phenylalanyl-tRNA aminoacylation
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_120_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_120_Specific_Function:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

# Metabolic_Enzyme_120_Pathway:
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_120_Reaction:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

# Metabolic_Enzyme_120_Pfam_Domain_Function:
PF08279:HTH_11;
PF01409:tRNA-synt_2d

# Metabolic_Enzyme_120_Signals:
None

# Metabolic_Enzyme_120_Transmembrane_Regions:
None

# Metabolic_Enzyme_120_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_120_EC_Link:
EC 6.1.1.20

# Metabolic_Enzyme_120_GenBank_ID_Protein:
2102679

# Metabolic_Enzyme_120_SwissProt_ID:
SYFA_HUMAN (Q9Y285)

# Metabolic_Enzyme_120_swissprot_Name:
Not Available

# Metabolic_Enzyme_120_Genecard_id:
FARSA

# Metabolic_Enzyme_120_Geneatlas_id:
FARSA

# Metabolic_Enzyme_120_hgnc_id:
HGNC:3592

# Metabolic_Enzyme_120_PDB_ID:
Not Available

# Metabolic_Enzyme_120_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_120_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_120_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_120_Gene_Sequence:
>1527 bp
ATGGCGGATGGTCAGGTGGCGGAACTGCTGCTCCGGCGGCTGGAGGCGTCTGATGGCGGC
CTGGACAGCGCCGAGTTGGCGGCTGAGCTGGGCATGGAGCACCAGGCGGTGGTGGGCGCC
GTGAAGAGCCTTCAGGCGCTGGGCGAGGTCATCGAGGCTGAACTTCGGTCCACCAAGCAC
TGGGAGCTTACTGCGGAGGGCGAGGAGATTGCCCGGGAGGGCAGCCATGAGGCCCGTGTG
TTTCGAAGCATTCCCCCAGAGGGCCTGGCCCAGAGCGAGCTTATGCGACTGCCCAGTGGC
AAAGTGGGCTTCAGCAAGGCCATGTCCAACAAGTGGATTCGGGTGGACAAGAGTGCGGCT
GACGGGCCCCGGGTGTTCCGAGTGGTGGACAGCATGGAGGATGAGGTGCAGCGGCGGCTC
CAGCTGGTCCGGGGGGGACAGGCTGAGAAGCTGGGGGAGAAGGAGAGGAGCGAGCTGAGG
AAGAGGAAGCTGTTGGCTGAAGTGACTCTGAAGACCTACTGGGTGAGCAAAGGCAGTGCC
TTTAGTACCAGCATCTCCAAGCAAGAGACAGAGCTGAGCCCAGAGATGATCTCCAGTGGC
TCTTGGCGGGACCGGCCCTTCAAGCCCTACAACTTCTTGGCCCACGGTGTCCTCCCCGAC
AGCGGCCACCTTCACCCGCTGCTCAAGGTCCGCTCCCAGTTCCGACAGATCTTCCTGGAG
ATGGGGTTCACCGAGATGCCGACTGATAACTTCATTGAGAGCTCCTTCTGGAACTTTGAC
GCCCTCTTCCAGCCCCAGCAGCACCCAGCCCGTGACCAGCACGACACCTTCTTCCTTCGA
GATCCAGCGGAGGCCCTGCAGCTCCCAATGGACTATGTCCAGCGGGTCAAGCGGACCCAC
TCTCAGGGCGGCTACGGCTCACAGGGGTACAAGTATAACTGGAAGCTGGACGAGGCCCGG
AAAAACCTACTGCGAACCCACACCACATCAGCCAGCGCCCGTGCGCTCTACCGCCTTGCC
CAGAAGAAGCCCTTCACTCCGGTCAAGTACTTCTCCATCGACCGCGTATTCCGGAATGAG
ACCCTGGACGCCACGCACCTGGCTGAGTTCCACCAGATCGAGGGCGTGGTGGCGGATCAT
GGTCTCACCTTGGGCCACCTCATGGGCGTTCTGCGGGAGTTCTTCACCAAGCTGGGTATC
ACGCAACTCCGCTTCAAGCCAGCCTACAACCCATACACAGAGCCCAGCATGGAGGTGTTC
AGCTACCACCAAGGCCTGAAGAAGTGGGTGGAGGTCGGAAACTCGGGGGTCTTCCGTCCA
GAGATGCTGCTGCCCATGGGGCTTCCCGAGAACGTGTCGGTCATTGCCTGGGGCCTCTCC
CTGGAGCGCCCAACGATGATCAAATATGGCATCAACAATATCCGGGAGCTGGTGGGCCAC
AAGGTGAACCTGCAGATGGTGTATGACAGTCCCCTGTGCCGCCTGGATGCCGAGCCGAGG
CCCCCTCCCACACAGGAGGCTGCGTGA

# Metabolic_Enzyme_120_GenBank_ID_Gene:
U07424

# Metabolic_Enzyme_120_Chromosome_Location:
Not Available

# Metabolic_Enzyme_120_Locus:
Not Available

# Metabolic_Enzyme_120_SNPs:
Not Available

# Metabolic_Enzyme_120_General_References:
9177188; 10049785; 12665801

# Metabolic_Enzyme_120_References:
Not Available

# Metabolic_Enzyme_121_ID:
5235

# Metabolic_Enzyme_121_Name:
Deoxycytidine kinase

# Metabolic_Enzyme_121_Synonyms:
dCK

# Metabolic_Enzyme_121_Gene_Name:
DCK

# Metabolic_Enzyme_121_Protein_Sequence:
>Deoxycytidine kinase
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
DFKDKYESLVEKVKEFLSTL

# Metabolic_Enzyme_121_Number_of_Residues:
260

# Metabolic_Enzyme_121_Molecular_Weight:
30519

# Metabolic_Enzyme_121_Theoretical_pI:
4.88

# Metabolic_Enzyme_121_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_121_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_121_Specific_Function:
Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents

# Metabolic_Enzyme_121_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_121_Reaction:
NTP + deoxycytidine = NDP + dCMP

# Metabolic_Enzyme_121_Pfam_Domain_Function:
PF01712:dNK

# Metabolic_Enzyme_121_Signals:
None

# Metabolic_Enzyme_121_Transmembrane_Regions:
None

# Metabolic_Enzyme_121_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_121_EC_Link:
EC 2.7.1.74

# Metabolic_Enzyme_121_GenBank_ID_Protein:
181510

# Metabolic_Enzyme_121_SwissProt_ID:
DCK_HUMAN (P27707)

# Metabolic_Enzyme_121_swissprot_Name:
Not Available

# Metabolic_Enzyme_121_Genecard_id:
DCK

# Metabolic_Enzyme_121_Geneatlas_id:
DCK

# Metabolic_Enzyme_121_hgnc_id:
HGNC:2704

# Metabolic_Enzyme_121_PDB_ID:
1P62

# Metabolic_Enzyme_121_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_121_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_121_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_121_Gene_Sequence:
>783 bp
ATGGCCACCCCGCCCAAGAGAAGCTGCCCGTCTTTCTCAGCCAGCTCTGAGGGGACCCGC
ATCAAGAAAATCTCCATCGAAGGGAACATCGCTGCAGGGAAGTCAACATTTGTGAATATC
CTTAAACAATTGTGTGAAGATTGGGAAGTGGTTCCTGAACCTGTTGCCAGATGGTGCAAT
GTTCAAAGTACTCAAGATGAATTTGAGGAACTTACAATGTCTCAGAAAAATGGTGGGAAT
GTTCTTCAGATGATGTATGAGAAACCTGAACGATGGTCTTTTACCTTCCAAACATATGCC
TGTCTCAGTCGAATAAGAGCTCAGCTTGCCTCTCTGAATGGCAAGCTCAAAGATGCAGAG
AAACCTGTATTATTTTTTGAACGATCTGTGTATAGTGACAGGTATATTTTTGCATCTAAT
TTGTATGAATCTGAATGCATGAATGAGACAGAGTGGACAATTTATCAAGACTGGCATGAC
TGGATGAATAACCAATTTGGCCAAAGCCTTGAATTGGATGGAATCATTTATCTTCAAGCC
ACTCCAGAGACATGCTTACATAGAATATATTTACGGGGAAGAAATGAAGAGCAAGGCATT
CCTCTTGAATATTTAGAGAAGCTTCATTATAAACATGAAAGCTGGCTCCTGCATAGGACA
CTGAAAACCAACTTCGATTATCTTCAAGAGGTGCCTATCTTAACACTGGATGTTAATGAA
GACTTTAAAGACAAATATGAAAGTCTGGTTGAAAAGGTCAAAGAGTTTTTGAGTACTTTG
TGA

# Metabolic_Enzyme_121_GenBank_ID_Gene:
M60527

# Metabolic_Enzyme_121_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_121_Locus:
4q13.3-q21.1

# Metabolic_Enzyme_121_SNPs:
rs4643786; rs16845677; rs1385986; rs936868; rs936869; rs1486271; rs6446999; rs4694362; rs6446988; rs10518080; rs10805074; rs7684954; rs12648166; rs4235090; rs2010401; rs7669445; rs4490428; rs7439745; rs1552381; rs16845668; rs11935198; rs4308342; rs3775289; rs7672935; rs6819369; rs12513206; rs1580469; rs7699819; rs2171195; rs7684573; rs7697366; rs13106279; rs17686997; rs11728260; rs7691350; rs7690840; rs7659473; rs9993633; rs6841923; rs9997995; rs6446989; rs11731434; rs12513202; rs6446998; rs2035576; rs2129173; rs12501375; rs11737567; rs7672339; rs16845626; rs7659998; rs1385987; rs7693891; rs7672954; rs4694360; rs4525938; rs1906021; rs11544786; rs34662212; rs5859247; rs13124044; rs13124045; rs3065775; rs35686785; rs1803484; rs13124290; rs5859246; rs28734949; rs10019874; rs4021444; rs34857131; rs34482223; rs36018698; rs11394166; rs11935525; rs35461637; rs28867977; rs12503595; rs7656043; rs35177789; rs34193080; rs13117017; rs34109101; rs35278579; rs35147498; rs11460671; rs7699712; rs28404918; rs11337561; rs34139336; rs4694363; rs3833976; rs34969740; rs34676003; rs35858453; rs35754685; rs35688113; rs36078513; rs28545112; rs9997790; rs4597793; rs35755135; rs34078875; rs4377559; rs7698012; rs2363439; rs12511143; rs11728201; rs35880082; rs11315015; rs35477149; rs28715337; rs11429170; rs7689110; rs34763060; rs2171194; rs35003502; rs34851032; rs11322673; rs7439562; rs4694361; rs35261981; rs34205711; rs2306744; rs7689093; rs28671303; rs28687395; rs12642438; rs1385985; rs3733399; rs6446977; rs6836323; rs7656269

# Metabolic_Enzyme_121_General_References:
1996353; 2013338; 9342341

# Metabolic_Enzyme_121_References:
Not Available

# Metabolic_Enzyme_122_ID:
5930

# Metabolic_Enzyme_122_Name:
Selenide, water dikinase 2

# Metabolic_Enzyme_122_Synonyms:
Selenophosphate synthetase 2; Selenium donor protein 2

# Metabolic_Enzyme_122_Gene_Name:
SEPHS2

# Metabolic_Enzyme_122_Protein_Sequence:
>Selenide, water dikinase 2
MAEASATGACGEAMAAAEGSSGPAGLTLGRSFSNYRPFEPQALGLSPSWRLTGFSGMKGC
GCKVPQEALLKLLAGLTRPDVRPPLGRGLVGGQEEASQEAGLPAGAGPSPTFPALGIGMD
SCVIPLRHGGLSLVQTTDFFYPLVEDPYMMGRIACANVLSDLYAMGITECDNMLMLLSVS
QSMSEEEREKVTPLMVKGFRDAAEEGGTAVTGGQTVVNPWIIIGGVATVVCQPNEFIMPD
SAVVGDVLVLTKPLGTQVAVNAHQWLDNPERWNKVKMVVSREEVELAYQEAMFNMATLNR
TAAGLMHTFNAHAATDITGFGILGHSQNLAKQQRNEVSFVIHNLPIIAKMAAVSKASGRF
GLLQGTSAETSGGLLICLPREQAARFCSEIKSSKYGEGHQAWIVGIVEKGNRTARIIDKP
RVIEVLPRGATAAVLAPDSSNASSEPSS

# Metabolic_Enzyme_122_Number_of_Residues:
448

# Metabolic_Enzyme_122_Molecular_Weight:
47259

# Metabolic_Enzyme_122_Theoretical_pI:
5.69

# Metabolic_Enzyme_122_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  selenide, water dikinase activity
Function:  catalytic activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_122_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_122_Specific_Function:
Synthesizes selenophosphate from selenide and ATP

# Metabolic_Enzyme_122_Pathway:
map00450  Selenoamino acid metabolism

# Metabolic_Enzyme_122_Reaction:
ATP + selenide + H2O = AMP + selenophosphate + phosphate

# Metabolic_Enzyme_122_Pfam_Domain_Function:
PF00586:AIRS;
PF02769:AIRS_C

# Metabolic_Enzyme_122_Signals:
None

# Metabolic_Enzyme_122_Transmembrane_Regions:
None

# Metabolic_Enzyme_122_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_122_EC_Link:
EC 2.7.9.3

# Metabolic_Enzyme_122_GenBank_ID_Protein:
14717790

# Metabolic_Enzyme_122_SwissProt_ID:
SPS2_HUMAN (Q99611)

# Metabolic_Enzyme_122_swissprot_Name:
Not Available

# Metabolic_Enzyme_122_Genecard_id:
SEPHS2

# Metabolic_Enzyme_122_Geneatlas_id:
SEPHS2

# Metabolic_Enzyme_122_hgnc_id:
HGNC:19686

# Metabolic_Enzyme_122_PDB_ID:
Not Available

# Metabolic_Enzyme_122_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_122_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_122_Subcellular_Location:
Not Available

# Metabolic_Enzyme_122_Gene_Sequence:
>1347 bp
ATGGCGGAAGCCTCGGCGACGGGCGCCTGCGGAGAGGCGATGGCAGCGGCGGAAGGCTCC
TCGGGCCCGGCGGGCTTGACTCTGGGCCGGAGCTTCTCGAACTACCGGCCCTTCGAGCCC
CAGGCGTTGGGCCTCAGCCCGAGCTGGCGGCTGACGGGCTTCTCCGGCATGAAGGGCTGA
GGCTGCAAGGTCCCGCAGGAGGCGCTGCTCAAACTCCTGGCGGGACTGACGCGGCCGGAC
GTGCGGCCCCCGCTGGGCCGGGGCCTGGTGGGTGGCCAGGAAGAGGCGTCCCAGGAAGCC
GGCCTGCCGGCAGGAGCGGGCCCCAGCCCCACCTTTCCAGCCCTGGGCATCGGGATGGAC
TCCTGCGTCATCCCCCTGAGGCACGGGGGCCTGTCACTGGTGCAGACCACGGACTTCTTT
TACCCCTTGGTAGAAGATCCCTACATGATGGGGCGCATAGCTTGTGCCAACGTGCTGAGT
GACCTCTACGCCATGGGGATTACTGAGTGTGACAACATGTTGATGTTACTCAGCGTCAGC
CAGAGTATGAGTGAGGAGGAACGCGAAAAGGTAACGCCACTCATGGTCAAAGGCTTTCGG
GATGCGGCTGAGGAAGGAGGGACGGCAGTGACCGGTGGGCAAACGGTGGTCAACCCTTGG
ATTATAATCGGTGGAGTTGCCACTGTAGTATGCCAACCAAATGAGTTCATAATGCCGGAC
AGCGCCGTCGTTGGGGACGTGCTGGTGTTAACCAAACCGTTAGGAACCCAGGTTGCTGTC
AATGCCCACCAATGGCTGGATAATCCTGAAAGATGGAATAAAGTAAAGATGGTGGTCTCC
AGAGAAGAGGTGGAGCTGGCCTATCAGGAAGCCATGTTCAATATGGCTACCCTCAACAGA
ACTGCTGCAGGTTTAATGCACACATTTAATGCCCATGCGGCCACAGATATCACAGGCTTT
GGCATTCTAGGACACTCCCAGAACCTTGCAAAACAACAAAGAAATGAAGTGTCCTTTGTT
ATTCATAATCTGCCAATAATTGCCAAGATGGCTGCCGTCAGCAAGGCCAGTGGACGGTTT
GGGCTTCTTCAAGGAACCTCAGCTGAAACCTCTGGGGGATTACTGATTTGTCTGCCAAGA
GAACAGGCGGCTCGCTTTTGTTCTGAAATCAAATCCTCCAAGTACGGAGAGGGTCACCAA
GCGTGGATCGTTGGCATTGTGGAAAAGGGAAACCGAACGGCCCGGATCATTGACAAGCCG
CGAGTTATTGAAGTCCTGCCTCGTGGGGCCACAGCTGCTGTTCTTGCTCCTGACAGTTCA
AATGCCTCCTCTGAGCCTAGCTCGTGA

# Metabolic_Enzyme_122_GenBank_ID_Gene:
U43286

# Metabolic_Enzyme_122_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_122_Locus:
16p11.2

# Metabolic_Enzyme_122_SNPs:
Not Available

# Metabolic_Enzyme_122_General_References:
7588067; 8986768

# Metabolic_Enzyme_122_References:
Not Available

# Metabolic_Enzyme_123_ID:
5931

# Metabolic_Enzyme_123_Name:
Ubiquitin-conjugating enzyme E2 R1

# Metabolic_Enzyme_123_Synonyms:
Ubiquitin-protein ligase R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; E2- CDC34

# Metabolic_Enzyme_123_Gene_Name:
CDC34

# Metabolic_Enzyme_123_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 R1
MARPLVPSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKA
RLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPVDDPQSGELPSERWNPTQNV
RTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRKQVLGTKVDAERDG
VKVPTTLAEYCVKTKAPAPDEGSDLFYDDYYEDGEVEEEADSCFGDDEDDSGTEES

# Metabolic_Enzyme_123_Number_of_Residues:
236

# Metabolic_Enzyme_123_Molecular_Weight:
26737

# Metabolic_Enzyme_123_Theoretical_pI:
4.15

# Metabolic_Enzyme_123_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_123_General_Function:
Not Available

# Metabolic_Enzyme_123_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of katenin

# Metabolic_Enzyme_123_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_123_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_123_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_123_Signals:
None

# Metabolic_Enzyme_123_Transmembrane_Regions:
None

# Metabolic_Enzyme_123_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_123_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_123_GenBank_ID_Protein:
388309

# Metabolic_Enzyme_123_SwissProt_ID:
UB2R1_HUMAN (P49427)

# Metabolic_Enzyme_123_swissprot_Name:
Not Available

# Metabolic_Enzyme_123_Genecard_id:
CDC34

# Metabolic_Enzyme_123_Geneatlas_id:
CDC34

# Metabolic_Enzyme_123_hgnc_id:
HGNC:1734

# Metabolic_Enzyme_123_PDB_ID:
Not Available

# Metabolic_Enzyme_123_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_123_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_123_Subcellular_Location:
Not Available

# Metabolic_Enzyme_123_Gene_Sequence:
>897 bp
ATTGCGGCGGCGCCAGAGCTGCTGGAGCGCTCGGGGTCCCCGGGCGGCGGCGGCGGCGCA
GAGGAGGAGGCAGGCGGCGGCCCCGGTGGCTCCCCCCCGGACGGTGCGCGGCCCGGCCCG
TCTCGCGAACTCGCGGTGGTCGCGCGGCCCCGCGCTGCTCCGACCCCGGGCCCCTCCGCC
GCCGCCATGGCTCGGCCGCTAGTGCCCAGCTCGCAGAAGGCGCTGCTGCTGGAGCTCAAG
GGGCTGCAGGAAGAGCCGGTCGAGGGATTCCGCGTGACACTGGTGGACGAGGGCGATCTA
TACAACTGGGAGGTGGCCATTTTCGGGCCCCCCAACACCTACTACGAGGGCGGCTACTTC
AAGGCGCGCCTCAAGTTCCCCATCGACTACCCATACTCTCCACCAGCCTTTCGGTTCCTG
ACCAAGATGTGGCACCCTAACATCTACGAGACGGGGGACGTGTGTATCTCCATCCTCCAC
CCGCCGGTGGACGACCCCCAGAGCGGGGAGCTGCCCTCAGAGAGGTGGAACCCCACGCAG
AACGTCAGGACCATTCTCCTGAGTGTGATCTCCCTCCTGAACGAGCCCAACACCTTCTCG
CCCGCAAACGTGGACGCCTCCGTGATGTACAGGAAGTGGAAAGAGAGCAAGGGGAAGGAT
CGGGAGTACACAGACATCATCCGGAAGCAGGTCCTGGGGACCAAGGTGGACGCGGAGCGT
GACGGCGTGAAGGTGCCCACCACGCTGGCCGAGTACTGCGTGAAGACCAAGGCGCCGGCG
CCCGACGAGGGCTCAGACCTCTTCTACGACGACTACTACGAGGACGGCGAGGTGGAGGAG
GAGGCCGACAGCTGCTTCGGGGACGATGAGGATGACTCTGGCACGGAGGAGTCCTGA

# Metabolic_Enzyme_123_GenBank_ID_Gene:
L22005

# Metabolic_Enzyme_123_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_123_Locus:
19p13.3

# Metabolic_Enzyme_123_SNPs:
rs6507; rs35573985; rs16990556; rs7150; rs7528; rs7529; rs16989752; rs16990665; rs16990659; rs892202; rs2396295; rs10402948; rs12976021; rs8104513; rs6510825; rs2011225; rs2011210; rs7254191; rs892204; rs892201; rs2011226; rs4919914; rs10415326; rs6510823; rs10853978; rs6510824; rs10853980; rs10853979; rs2011211; rs892203; rs11883123; rs1108113; rs17841746; rs17672563; rs2288952; rs11667548; rs17841766; rs7249135; rs7259421; rs4264506; rs12609463; rs10415110; rs12984645; rs16990634; rs2288956; rs11881685; rs2288951; rs12979110; rs3930364; rs12608630; rs10409849; rs1982084; rs12983064; rs2288955; rs1108115; rs2288954; rs16990625; rs17841738; rs3930363; rs10421502; rs7508345; rs16990590; rs7254483; rs1108114; rs2288953; rs16990597; rs12972025; rs12461965; rs17841732; rs4541184; rs8107361; rs7255072; rs12984443; rs16990500; rs2011204; rs16990648; rs17841733; rs17841729; rs16990626; rs17841735; rs16990622; rs12984468; rs16990508; rs16990539; rs16990638; rs17841752; rs16990510; rs16990893; rs16990550; rs12985200; rs16990600; rs16989782; rs17841737; rs17841748; rs10406729; rs10419323; rs16990506; rs16990502; rs17841731; rs17841750; rs7249253; rs3930365; rs17841754; rs10426138; rs16989793; rs16989750; rs16990493; rs16989748; rs17425549; rs16989726; rs17435422; rs16990498; rs16989712; rs16989728; rs17425535; rs16989724; rs16990494; rs16990650; rs16990554; rs11557525; rs16990654; rs11557524; rs16989755; rs16990656; rs1313711; rs7252421; rs11457359; rs11878756; rs7256168; rs12985246; rs16990532; rs12978889; rs5826698; rs16990585; rs11881969; rs16990583; rs16989783; rs7259097; rs12972728; rs16990571; rs17841765; rs7255299; rs12984199; rs17841742; rs17841759; rs12973414; rs34195292; rs41443449; rs16989771; rs16990628; rs16990514; rs16989788; rs12979793; rs17841747; rs16990568; rs17841736; rs16990517; rs11881961; rs1313710; rs5826699; rs16990605; rs17841762; rs12984708; rs17841751; rs17841758; rs28558712; rs36028188; rs12984899; rs16990594; rs16990610; rs16990522; rs1313713; rs16989781; rs34823529; rs34635182; rs16990537; rs17841775; rs36104500; rs17841760; rs12985216; rs16990616; rs17841755; rs12978637; rs28731438; rs28575072; rs16990545; rs16990608; rs12985212; rs12983594; rs16990892; rs34534471; rs3930362; rs12984900; rs34460804; rs16990542; rs28687356; rs12984950; rs12984940; rs17841761; rs17425573; rs35184527; rs16990530; rs12979642; rs5826700; rs12985201; rs17841749; rs12978802; rs12985264; rs1313712; rs17425542; rs16989733; rs16989717; rs16989721; rs11368160; rs16990496; rs16990492; rs16989730; rs16989741; rs16989739; rs5826697; rs16989736; rs34509095; rs16989743; rs11882673; rs12459388; rs12608511; rs12981692; rs1599882; rs1599883; rs1599884; rs1865117; rs2070794; rs2070795; rs2070796; rs2070797; rs2070798; rs2070799; rs2396293; rs2894583; rs3745923; rs3760874; rs3760879; rs3760880; rs3810355; rs3826891; rs4919841; rs4919846; rs745403; rs747354; rs892209

# Metabolic_Enzyme_123_General_References:
8248134; 10918611

# Metabolic_Enzyme_123_References:
Not Available

# Metabolic_Enzyme_124_ID:
5932

# Metabolic_Enzyme_124_Name:
DNA ligase 1

# Metabolic_Enzyme_124_Synonyms:
DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1

# Metabolic_Enzyme_124_Gene_Name:
LIG1

# Metabolic_Enzyme_124_Protein_Sequence:
>DNA ligase 1
MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKA
ARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPK
RRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQ
PTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVK
KEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIE
EVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQ
ATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSAST
AKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAM
VDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPL
KPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPD
IISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAF
DLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCE
GLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLL
ASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSA
VWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQ
SQIQNQQGEDSGSDPEDTY

# Metabolic_Enzyme_124_Number_of_Residues:
919

# Metabolic_Enzyme_124_Molecular_Weight:
101737

# Metabolic_Enzyme_124_Theoretical_pI:
5.30

# Metabolic_Enzyme_124_GO_Classification:
>>>
Function:  DNA ligase (ATP) activity
Function:  nucleic acid binding
Function:  DNA binding
Function:  DNA ligase (ATP) activity
Function:  DNA ligase (ATP) activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  DNA ligase activity
Function:  DNA ligase (ATP) activity
 ||
>>>
Process:  DNA recombination
Process:  DNA repair
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  DNA metabolism
Process:  DNA replication
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_124_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_124_Specific_Function:
This protein seals, during DNA replication, DNA recombination and DNA repair, nicks in double-stranded DNA

# Metabolic_Enzyme_124_Pathway:
Not Available

# Metabolic_Enzyme_124_Reaction:
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m

# Metabolic_Enzyme_124_Pfam_Domain_Function:
PF04679:DNA_ligase_A_C;
PF01068:DNA_ligase_A_M;
PF04675:DNA_ligase_A_N

# Metabolic_Enzyme_124_Signals:
None

# Metabolic_Enzyme_124_Transmembrane_Regions:
None

# Metabolic_Enzyme_124_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_124_EC_Link:
EC 6.5.1.1

# Metabolic_Enzyme_124_GenBank_ID_Protein:
187143

# Metabolic_Enzyme_124_SwissProt_ID:
DNL1_HUMAN (P18858)

# Metabolic_Enzyme_124_swissprot_Name:
Not Available

# Metabolic_Enzyme_124_Genecard_id:
LIG1

# Metabolic_Enzyme_124_Geneatlas_id:
LIG1

# Metabolic_Enzyme_124_hgnc_id:
HGNC:6598

# Metabolic_Enzyme_124_PDB_ID:
Not Available

# Metabolic_Enzyme_124_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_124_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_124_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_124_Gene_Sequence:
>2760 bp
ATGCAGCGAAGTATCATGTCATTTTTCCACCCCAAGAAAGAGGGTAAAGCAAAGAAGCCT
GAGAAGGAGGCATCCAATAGCAGCAGAGAGACGGAGCCCCCTCCAAAGGCGGCACTGAAG
GAGTGGAATGGAGTGGTGTCCGAGAGTGACTCTCCGGTGAAGAGGCCAGGGAGGAAGGCG
GCCCGGGTCCTGGGCAGCGAAGGGGAAGAGGAGGATGAAGCCCTTAGCCCTGCTAAAGGC
CAGAAGCCTGCCCTGGACTGCTCACAGGTCTCCCCGCCCCGTCCTGCCACATCTCCTGAG
AACAATGCTTCCCTCTCTGACACCTCTCCCATGGACAGTTCCCCATCAGGGATTCCGAAG
CGTCGCACAGCTCGGAAGCAGCTCCCGAAACGGACCATTCAGGAAGTCCTGGAAGAGCAG
AGTGAGGACGAGGACAGAGAAGCCAAGAGGAAGAAGGAGGAGGAAGAAGAGGAGACCCCG
AAAGAAAGCCTCACAGAGGCTGAAGTGGCAACAGAGAAGGAAGGAGAAGACGGGGACCAG
CCCACCACGCCTCCCAAGCCCCTAAAGACCTCCAAAGCAGAGACCCCGACGGAAAGCGTT
TCAGAGCCTGAGGTGGCCACGAAGCAGGAACTGCAGGAGGAGGAAGAGCAGACCAAGCCT
CCCCGCAGAGCTCCCAAGACGCTCAGCAGCTTCTTCACCCCCCGGAAGCCAGCAGTCAAA
AAAGAAGTGAAGGAAGAGGAGCCAGGGGCTCCAGGAAAGGAGGGAGCTGCTGAGGGACCC
CTGGATCCATCTGGTTACAATCCTGCCAAGAACAACTATCATCCCGTGGAAGATGCCTGC
TGGAAACCGGGCCAGAAGGTTCCTTACCTGGCTGTGGCCCGGACGTTTGAGAAGATCGAG
GAGGTGTCTGCTCGGCTCCGGATGGTGGAGACGCTGAGCAACTTGCTGCGCTCCGTGGTG
GCCCTGTCGCCTCCAGACCTCCTCCCTGTCCTCTACCTCAGCCTCAACCACCTTGGGCCA
CCCCAGCAGGGCCTGGAGCTTGGCGTGGGTGATGGTGTCCTTCTCAAGGCAGTGGCCCAG
GCCACAGGTCGGCAGCTGGAGTCCGTCCGGGCTGAGGCAGCCGAGAAAGGCGACGTGGGG
CTGGTGGCCGAGAACAGCCGCAGCACCCAGAGGCTCATGCTGCCACCACCTCCGCTCACT
GCCTCCGGGGTCTTCAGCAAGTTCCGCGACATCGCCAGGCTCACTGGCAGTGCTTCCACA
GCCAAGAAGATAGACATCATCAAAGGCCTCTTTGTGGCCTGCCGCCACTCAGAAGCCCGG
TTCATCGCTAGGTCCCTGAGCGGACGGCTGCGCCTTGGGCTGGCAGAGCAGTCGGTGCTG
GCTGCCCTCTCCCAGGCAGTGAGCCTCACGCCCCCGGGCCAAGAATTCCCACCAGCCATG
GTGGATGCTGGGAAGGGCAAGACAGCAGAGGCCAGAAAGACGTGGCTGGAGGAGCAAGGC
ATGATCCTGAAGCAGACGTTCTGCGAGGTTCCCGACCTGGACCGAATTATCCCCGTGCTG
CTGGAGCACGGCCTGGAACGTCTCCCGGAGCACTGCAAGCTGAGCCCAGGGATTCCCCTG
AAACCAATGTTGGCCCATCCCACCCGGGGCATCAGCGAGGTCCTGAAACGCTTTGAGGAG
GCAGCTTTCACCTGCGAATACAAATATGACGGGCAGAGGGCACAGATCCACGCCCTGGAA
GGCGGGGAGGTGAAGATCTTCAGCAGGAATCAGGAAGACAACACTGGGAAGTACCCGGAC
ATCATCAGCCGCATCCCCAAGATTAAACTCCCATCGGTCACATCCTTCATCCTGGACACC
GAAGCCGTGGCTTGGGACCGGGAAAAGAAGCAGATCCAGCCATTCCAAGTGCTCACCACC
CGCAAACGCAAGGAGGTGGATGCGTCTGAGATCCAGGTGCAGGTGTGTTTGTACGCCTTC
GACCTCATCTACCTCAATGGAGAGTCCCTGGTACGTGAGCCCCTTTCCCGGCGCCGGCAG
CTGCTCCGGGAGAACTTTGTGGAGACAGAGGGCGAGTTTGTCTTCGCCACCTCCCTGGAC
ACCAAGGACATCGAGCAGATCGCCGAGTTCCTGGAGCAGTCAGTGAAAGACTCCTGCGAG
GGGCTGATGGTGAAGACCCTGGATGTTGATGCCACCTACGAGATCGCCAAGAGATCGCAC
AACTGGCTCAAGCTGAAGAAGGACTACCTTGATGGCGTGGGTGACACCCTGGACCTGGTG
GTGATCGGCGCCTACCTGGGCCGGGGGAAGCGGGCCGGCCGGTACGGGGGCTTCCTGCTG
GCCTCCTACGACGAGGACAGTGAGGAGCTGCAGGCCATATGCAAGCTTGGAACTGGCTTC
AGTGATGAGGAGCTGGAGGAGCATCACCAGAGCCTCAAGGCGCTGGTGCTGCCCAGCCCA
CGCCCTTACGTGCGGATAGATGGCGCTGTGATTCCCGACCACTGGCTGGACCCCAGCGCT
GTGTGGGAGGTGAAGTGCGCTGACCTCTCCCTCTCTCCCATCTACCCTGCTGCGCGGGGC
CTGGTGGATAGTGACAAGGGCATCTCCCTTCGCTTCCCTCGGTTTATTCGAGTCCGTGAA
GACAAGCAGCCGGAGCAGGCCACCACCAGTGCTCAGGTGGCCTGTTTGTACCGGAAGCAA
AGTCAGATTCAGAACCAACAAGGCGAGGACTCAGGCTCTGACCCTGAAGATACCTACTAA


# Metabolic_Enzyme_124_GenBank_ID_Gene:
M36067

# Metabolic_Enzyme_124_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_124_Locus:
19q13.2-q13.3

# Metabolic_Enzyme_124_SNPs:
rs3730911; rs3730933; rs3730980; rs3731003; rs4987068; rs11668325; rs3730966; rs11666150; rs3731008; rs3730863; rs20580; rs1803907; rs3731027; rs3730982; rs13436; rs20581; rs35100567; rs4987069; rs439132; rs2386522; rs20579; rs251692; rs10426471; rs2386521; rs3730844; rs12611390; rs12463259; rs3730843; rs12463260; rs12611384; rs3731047; rs2386523; rs2116492; rs102347; rs2163619; rs274892; rs156640; rs274893; rs7246512; rs3730858; rs3730946; rs3731029; rs411073; rs436303; rs1971775; rs274889; rs156634; rs416844; rs3730945; rs3730862; rs3730940; rs2304136; rs3730954; rs274883; rs3786764; rs3731030; rs3730931; rs3730857; rs3730898; rs3730942; rs274885; rs3730849; rs754948; rs8100261; rs4801749; rs3730913; rs3730901; rs3730860; rs187998; rs3730850; rs3730938; rs274884; rs3730943; rs3730990; rs3730865; rs175628; rs16981560; rs3730994; rs3730939; rs3730989; rs156641; rs2288882; rs3730951; rs7247570; rs251690; rs2060233; rs156637; rs187999; rs3730905; rs3730974; rs274860; rs3729512; rs156646; rs274862; rs3730883; rs175627; rs3730912; rs156639; rs3729518; rs153023; rs3729519; rs3730880; rs3731011; rs3730900; rs380487; rs3730926; rs9304673; rs3730987; rs3730914; rs3730872; rs3730908; rs3730869; rs251691; rs3730944; rs3730924; rs156638; rs442670; rs274897; rs7248694; rs3730886; rs9304672; rs3786763; rs392891; rs3730959; rs2060234; rs3730976; rs12462811; rs3730986; rs3730894; rs3730919; rs12985215; rs6509360; rs3730910; rs10420285; rs3729520; rs3731007; rs156633; rs3730903; rs7246229; rs3730932; rs3730920; rs2288881; rs5025733; rs166683; rs3731034; rs2241721; rs2288878; rs156645; rs10500298; rs3730881; rs274861; rs274898; rs3730887; rs2067286; rs3731004; rs2288879; rs3731013; rs3731014; rs3730867; rs3731023; rs3730873; rs3730969; rs156648; rs153021; rs3730878; rs870231; rs251699; rs8108486; rs3731044; rs3730876; rs3730882; rs3730917; rs11672629; rs3730856; rs156644; rs3730977; rs3730902; rs3731002; rs3730995; rs2060235; rs2915637; rs3730895; rs3730958; rs8108407; rs274896; rs10445576; rs3730915; rs3730897; rs3731037; rs3730889; rs8113271; rs3730853; rs156647; rs3731009; rs16981368; rs3731022; rs3730859; rs3731032; rs10409171; rs3730868; rs3730851; rs3731012; rs3731020; rs3730870; rs274886; rs3730922; rs10423203; rs3730961; rs3731043; rs3731005; rs3731015; rs3730864; rs12986286; rs3730885; rs3731035; rs8104114; rs201186; rs3729517; rs3730888; rs16981519; rs10420093; rs3730877; rs7252139; rs2288880; rs3730988; rs156643; rs12610623; rs3731024; rs3730921; rs3730996; rs4987071; rs3730909; rs419664; rs3078278; rs3730852; rs153022; rs16981356; rs3731036; rs2288883; rs3730861; rs3731050; rs3731052; rs3731049; rs3731051; rs4987181; rs11879148; rs3730855; rs4987070; rs34087182; rs3730947; rs12981963; rs35485148; rs11273301; rs5828336; rs3730845; rs12463269; rs12978112; rs28490966; rs8109984; rs35239737; rs10424875; rs34246370; rs34824188; rs3730847; rs12980783; rs34115345; rs34864830; rs3730999; rs34060696; rs12461805; rs34350172; rs3730983; rs35538558; rs28674712; rs3730953; rs34623721; rs28549163; rs10418941; rs3833254; rs3730906; rs12980617; rs35469253; rs12461815; rs10625177; rs34337010; rs12461807; rs41561716; rs3730979; rs8112003; rs35546700; rs34430179; rs3730904; rs35879428; rs10405578; rs3730923; rs35056937; rs34833018; rs4987073; rs3731033; rs3730962; rs3786758; rs3731017; rs3731018; rs34280126; rs34777443; rs3730929; rs35408335; rs34073314; rs34904322; rs3730928; rs4987072; rs34289915; rs3731041; rs3731031; rs3745736; rs41543521; rs36185366; rs274888; rs11444392; rs3730964; rs3730941; rs190656; rs274882; rs3730937; rs34576382; rs12975748; rs3730890; rs41562612; rs2386965; rs10714747; rs8100102; rs36027045; rs34969875; rs35048967; rs274894; rs3730893; rs10567824; rs3730935; rs34148826; rs415465; rs34407762; rs274890; rs3730984; rs3731028; rs35880585; rs35127581; rs393404; rs35844660; rs35858886; rs35879443; rs3730971; rs3730866; rs34423539; rs10415947; rs35526649; rs35384174; rs156642; rs28759107; rs3730907; rs3730930; rs10533938; rs41562116; rs10413642; rs274895; rs34884434; rs870232; rs35976022; rs5828335; rs41545337; rs3730957; rs274863; rs3730892; rs36171813; rs3730963; rs10603723; rs3730950; rs12981414; rs3731010; rs28453888; rs41540714; rs3730936; rs2082319; rs3730975; rs41555716; rs34642096; rs34510630; rs41563420; rs41541014; rs3730965; rs3731039; rs34909809; rs3760813; rs34811835; rs34134727; rs35986724; rs12974614; rs12104196; rs11353435; rs12979997; rs3731040; rs274887; rs35936540; rs3730916; rs35691497; rs34448490; rs34430602; rs3730896; rs274891; rs3730967; rs3730981; rs35212188; rs34430527; rs35813149; rs420981; rs34967871; rs35061464; rs34123451; rs5828334; rs34584742; rs10405655; rs10407902; rs10409906; rs10411910; rs11083918; rs11564498; rs12462020; rs1654377; rs251693; rs274866; rs274867; rs274869; rs274870; rs274871; rs274873; rs274875; rs274876; rs34472427; rs3729527; rs3730842; rs380359; rs7250148

# Metabolic_Enzyme_124_General_References:
2204063; 1881902; 1581963

# Metabolic_Enzyme_124_References:
Not Available

# Metabolic_Enzyme_125_ID:
5977

# Metabolic_Enzyme_125_Name:
Adenylate cyclase type 7

# Metabolic_Enzyme_125_Synonyms:
Adenylate cyclase type VII; ATP pyrophosphate-lyase 7; Adenylyl cyclase 7

# Metabolic_Enzyme_125_Gene_Name:
ADCY7

# Metabolic_Enzyme_125_Protein_Sequence:
>Adenylate cyclase type 7
MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPS
RHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAA
CAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQL
LANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAH
ISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKEL
VVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQ
VREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT
LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRA
SVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRS
EDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACA
SLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISER
VETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLP
YYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKP
NGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFET
MENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKE
GLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAH
IGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVAS
RMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN


# Metabolic_Enzyme_125_Number_of_Residues:
1080

# Metabolic_Enzyme_125_Molecular_Weight:
120310

# Metabolic_Enzyme_125_Theoretical_pI:
8.16

# Metabolic_Enzyme_125_GO_Classification:
>>>
Function:  cyclase activity
Function:  adenylate cyclase activity
Function:  catalytic activity
Function:  lyase activity
Function:  phosphorus-oxygen lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  cyclic nucleotide biosynthesis
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Metabolic_Enzyme_125_General_Function:
Signal transduction mechanisms 

# Metabolic_Enzyme_125_Specific_Function:
This is a membrane-bound, calcium-inhibitable adenylyl cyclase

# Metabolic_Enzyme_125_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_125_Reaction:
ATP = 3',5'-cyclic AMP + diphosphate

# Metabolic_Enzyme_125_Pfam_Domain_Function:
PF06327:DUF1053;
PF00211:Guanylate_cyc

# Metabolic_Enzyme_125_Signals:
None

# Metabolic_Enzyme_125_Transmembrane_Regions:
34-54
63-83
95-117
122-142
147-167
176-196
595-615
620-640
669-688
718-737
746-773
794-814

# Metabolic_Enzyme_125_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_125_EC_Link:
EC 4.6.1.1

# Metabolic_Enzyme_125_GenBank_ID_Protein:
40788941

# Metabolic_Enzyme_125_SwissProt_ID:
ADCY7_HUMAN (P51828)

# Metabolic_Enzyme_125_swissprot_Name:
Not Available

# Metabolic_Enzyme_125_Genecard_id:
ADCY7

# Metabolic_Enzyme_125_Geneatlas_id:
ADCY7

# Metabolic_Enzyme_125_hgnc_id:
HGNC:238

# Metabolic_Enzyme_125_PDB_ID:
Not Available

# Metabolic_Enzyme_125_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_125_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_125_Subcellular_Location:
Membrane; multi-pass membrane protein

# Metabolic_Enzyme_125_Gene_Sequence:
>3267 bp
CGACACGCGTGCCAAGGGTGGAGGATGCCAGCCAAGGGGCGCTACTTCCTCAACGAGGGC
GAGGAGGGCCCTGACCAAGATGCGCTCTACGAGAAGTACCAGCTCACCAGCCAGCATGGG
CCGCTGCTGCTCACGCTCCTGCTGGTGGCCGCCACTGCCTGCGTGGCCCTCATCATCATT
GCCTTCAGCCAGGGGGACCCCTCCAGACACCAGGCCATTCTGGGCATGGCGTTCCTGGTG
CTGGCGGTGTTTGCGGCCCTCTCTGTGCTGATGTACGTCGAGTGTCTCCTGCGGCGCTGG
CTCAGGGCCTTGGCGCTGCTCACCTGGGCCTGCTTGGTGGCGCTGGGCTATGTGCTGGTG
TTCGACGCATGGACAAAGGCGGCCTGTGCGTGGGAGCAGGTGCCCTTCTTCCTGTTCATT
GTCTTCGTGGTGTACACACTACTGCCCTTCAGCATGCGGGGCGCTGTCGCCGTTGGGGCC
GTCTCCACTGCCTCCCACCTCCTGGTGCTCGGTTCTTTGATGGGAGGCTTCACGACACCC
AGTGTCCGGGTGGGGCTGCAGCTGCTGGCCAACGCAGTCATCTTCCTGTGTGGGAACCTG
ACAGGCGCCTTCCACAAGCACCAAATGCAGGATGCGTCCCGGGACCTCTTCACCTACACT
GTGAAGTGCATCCAGATCCGCCGGAAGCTGCGCATCGAGAAGCGCCAGCAGGAGAACCTG
CTGCTGTCAGTGCTTCCGGCCCACATCTCCATGGGCATGAAGCTGGCCATCATCGAACGG
CTCAAGGAGCATGGTGACCGTCGCTGCATGCCTGACAACAACTTCCACAGCCTCTACGTC
AAGAGGCACCAGAATGTCAGCATCCTCTATGCGGACATCGTGGGCTTCACGCAGCTGGCC
AGCGACTGTTCTCCCAAGGAGCTGGTGGTGGTGCTGAATGAGCTCTTTGGCAAGTTCGAC
CAGATCGCCAAGGCCAACGAGTGCATGCGAATCAAGATCCTCGGCGACTGCTACTACTGT
GTATCGGGCCTGCCCGTGTCGCTGCCTACCCACGCCCGGAACTGCGTGAAGATGGGGCTG
GACATGTGCCAGGCCATCAAGCAGGTGCGGGAGGCCACGGGCGTGGACATCAACATGCGT
GTGGGCATACACTCGGGGAATGTGCTGTGCGGGGTCATCGGGCTGCGCAAGTGGCAGTAT
GACGTGTGGTCCCACGACGTGTCCCTGGCCAACCGGATGGAGGCAGCCGGAGTACCCGGC
CGGGTGCACATCACGGAGGCCACGCTAAAGCACCTGGACAAGGCGTACGAGGTGGAGGAT
GGGCACGGGCAGCAGCGGGACCCCTACCTCAAGGAGATGAACATCCGCACCTACCTGGTC
ATCGACCCCCGGAGCCAGCAGCCACCCCCGCCCAGCCAACACCTCCCCAGGCCCAAGGGG
GACGCGGCCCTGAAGATGCGGGCGTCAGTGCGCATGACCCGGTACCTCGAGTCCTGGGGG
GCGGCACGGCCCTTTGCACATCTCAACCACCGTGAGAGCGTGAGCAGTGGTGAGACCCAC
GTCCCCAACGGGCGGAGGCCTAAGAGCGTTCCCCAGCGCCACCGCCGGACCCCAGACAGA
AGCATGTCCCCCAAGGGGCGGTCGGAGGATGACTCGTACGATGACGAGATGCTGTCAGCC
ATTGAGGGGCTCAGCTCCACGAGGCCCTGCTGCTCCAAGTCCGATGACTTCTACACCTTT
GGGTCCATCTTCCTGGAGAAGGGCTTTGAGCGCGAGTACCGCCTGGCACCCATCCCCCGG
GCCCGCCACGACTTTGCCTGCGCCAGCCTGATCTTCGTCTGCATCCTGCTCGTCCATGTC
CTGCTCATGCCCAGGACGGCGGCACTGGGTGTGTCCTTCGGGCTGGTGGCCTGTGTACTG
GGGCTGGTGCTGGGCCTGTGCTTTGCCACCAAGTTCTCGAGGTGCTGCCCAGCTCGGGGG
ACGCTCTGCACTATCTCTGAGAGGGTGGAGACACAGCCCCTGCTGAGGCTGACCCTGGCC
GTCCTGACCATCGGCAGCCTGCTCACTGTGGCCATCATCAACCTGCCCCTGATGCCTTTC
CAAGTTCCAGAGCTGCCTGTTGGCAATGAGACAGGCCTACTGGCCGCGAGCAGCAAGACA
AGAGCCCTGTGTGAGCCCCTCCCGTACTACACCTGCAGCTGTGTCCTGGGCTTCATCGCC
TGCTCGGTCTTCCTGAGGATGAGCCTGGAGCCAAAGGTTGTGCTGCTGACAGTGGCCCTG
GTGGCCTACCTGGTGCTCTTCAACCTCTCCCCATGCTGGCAGTGGGACTGCTGCGGCCAA
GGCCTGGGCAACCTCACCAAGCCCAACGGCACCACCAGTGGCACCCCTAGCTGTTCCTGG
AAGGACCTGAAGACCATGACCAATTTCTACCTGGTCCTGTTCTACATCACCCTGCTTACA
CTCTCCAGACAGATTGACTATTACTGCCGCTTGGACTGCCTATGGAAGAAGAAGTTCAAG
AAGGAGCACGAGGAGTTTGAGACCATGGAGAACGTGAACCGCCTTCTTCTGGAGAACGTC
CTGCCAGCCCACGTGGCTGCCCACTTTATCGGTGACAAGTTAAACGAGGACTGGTACCAT
CAGTCCTATGACTGCGTCTGTGTCATGTTTGCCTCCGTGCCGGACTTCAAAGTGTTCTAC
ACAGAGTGCGATGTCAACAAAGAAGGGCTGGAGTGCCTACGCCTGCTCAATGAGATCATT
GCCGACTTCGACGAGCTCCTACTGAAGCCCAAGTTCAGCGGCGTGGAGAAGATCAAGACC
ATCGGCAGCACGTACATGGCAGCTGCAGGGCTCAGCGTCGCCTCAGGGCACGAGAACCAG
GAGCTGGAGCGGCAGCATGCCCACATTGGTGTCATGGTGGAGTTCAGCATCGCCCTGATG
AGTAAGCTGGACGGCATCAACAGGCACTCCTTCAACTCCTTCCGCCTCCGCGTCGGCATA
AACCATGGGCCTGTGATTGCTGGAGTGATTGGGGCCCGAAAACCTCAGTATGACATCTGG
GGAAACACTGTCAATGTGGCCAGCCGAATGGAAAGCACTGGAGAACTTGGGAAAATCCAG
GTTACCGAGGAGACCTGCACCATCCTCCAGGGCCTCGGGTACTCTTGTGAATGCCGTGGC
CTGATCAACGTCAAAGGCAAAGGCGAGCTGAGGACTTACTTTGTCTGTACGGACACTGCC
AAGTTTCAGGGGCTGGGGCTGAACTGA

# Metabolic_Enzyme_125_GenBank_ID_Gene:
D25538

# Metabolic_Enzyme_125_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_125_Locus:
16q12-q13

# Metabolic_Enzyme_125_SNPs:
rs17289102; rs11861332; rs1064448; rs1872691; rs11644926; rs1540624; rs2302681; rs8052384; rs9939322; rs4785211; rs9936021; rs4785403; rs8061123; rs9926131; rs7191958; rs4785210; rs4785402; rs3813755; rs729229; rs2302712; rs11649380; rs9924714; rs8045659; rs8049122; rs2302680; rs7193839; rs11648839; rs7193875; rs2302717; rs2302715; rs12445243; rs11859417; rs728962; rs2302716; rs11861597; rs7202127; rs7186882; rs12444679; rs8056293; rs3833062; rs2302679; rs9927261; rs8060642; rs4082435; rs3826173; rs3892156; rs3760012; rs3760011; rs28514808; rs7359472; rs2230664; rs1064447; rs8051594; rs35787328; rs10589177; rs9940992; rs4785407; rs12918980; rs12444266; rs7500891; rs5816686; rs35969283; rs34860956; rs34493825; rs9937781; rs35262781; rs2302678; rs13332825; rs12932721; rs34996336; rs2302714; rs11640409; rs12932722; rs16948389; rs34039653; rs28510819; rs28432797; rs3841348; rs3214383; rs3815562; rs35078746; rs34191947; rs11403746; rs4502213; rs34381393; rs7197662; rs35284914; rs28403987; rs2302713; rs12919306; rs35003370; rs35732926; rs35829985; rs34216705; rs11352304; rs10577557; rs12444236; rs12924307; rs12598249; rs11417859; rs12443620; rs8048743; rs34009001; rs34686094; rs8053067; rs1078151; rs11644043; rs11645133; rs11649621; rs11860192; rs17216076; rs1872688; rs34176129; rs3760013; rs3760014; rs4497684; rs4785401; rs4785408; rs7184476; rs7184802; rs7196135; rs7204026; rs751127; rs8046783; rs8057103; rs8061808; rs9922362; rs9926720; rs9937029; rs9940619

# Metabolic_Enzyme_125_General_References:
7584026

# Metabolic_Enzyme_125_References:
16413094; 16648610; 17008420

# Metabolic_Enzyme_126_ID:
8700

# Metabolic_Enzyme_126_Name:
Hypothetical protein DKFZp666F229

# Metabolic_Enzyme_126_Synonyms:
Not Available

# Metabolic_Enzyme_126_Gene_Name:
DKFZp666F229

# Metabolic_Enzyme_126_Protein_Sequence:
>Hypothetical protein DKFZp666F229
DDLYHWSVESYSDFWAEFWKFSGIVFSRVYDEVVDTSKGIADVPEWFKGSRLNYAENLLR
HKENDRVALYIAREGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGDRVVGYLPNSEHAV
EAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHNHMEKLQQVV
KGLPDLKKVVVIPYVSSRENIDLSKIPNSVFLDDFLATGTSEQAPQLEFEQLPFSHPLFI
MFSSGTTGAPKCMVHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVGWMMWNWMVSLLAT
GAAMVLYDGSPLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEEKAMKPVETHSLQMLHTI
LSTGSPLKAQSYEYVYRCIKSSILLGSISGGTDIISCFMGHNFSLPVYKGEIQARNLGMA
VEAWNEEGKAVWGESGELVCTKPIPCQPTHFWNDENGNKYRKAYFSKFPGIWAHGDYCRI
NPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERVILFL
KMASGHAFQPDLVKRIRDAIRMGLSARHVPSLILETKGIPYTLNGKKVEVAVKQIIAGKA
VEQGGAFSNPETLDLYRDIPELQGF

# Metabolic_Enzyme_126_Number_of_Residues:
625

# Metabolic_Enzyme_126_Molecular_Weight:
69801

# Metabolic_Enzyme_126_Theoretical_pI:
6.37

# Metabolic_Enzyme_126_GO_Classification:
>>>
 Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-sulfur bonds
Function:  CoA-ligase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  isoprenoid metabolism
Process:  isoprenoid biosynthesis
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_126_General_Function:
Lipid transport and metabolism

# Metabolic_Enzyme_126_Specific_Function:
Not Available

# Metabolic_Enzyme_126_Pathway:
Not Available

# Metabolic_Enzyme_126_Reaction:
Not Available

# Metabolic_Enzyme_126_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_126_Signals:
1-303

# Metabolic_Enzyme_126_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_126_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_126_EC_Link:
EC 6.2.1.16

# Metabolic_Enzyme_126_GenBank_ID_Protein:
52545788

# Metabolic_Enzyme_126_SwissProt_ID:
Q658Q8_HUMAN (Q658Q8)

# Metabolic_Enzyme_126_swissprot_Name:
Not Available

# Metabolic_Enzyme_126_Genecard_id:
DKFZp666F229

# Metabolic_Enzyme_126_Geneatlas_id:
DKFZp666F229

# Metabolic_Enzyme_126_hgnc_id:
HGNC:21298

# Metabolic_Enzyme_126_PDB_ID:
Not Available

# Metabolic_Enzyme_126_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_126_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_126_Subcellular_Location:
Not Available

# Metabolic_Enzyme_126_Gene_Sequence:
>1878 bp
GATGACTTGTACCATTGGTCCGTTGAGTCATATTCAGACTTCTGGGCAGAGTTCTGGAAA
TTCAGTGGAATTGTCTTCTCACGTGTGTATGATGAGGTTGTGGACACATCGAAAGGAATC
GCAGATGTCCCCGAGTGGTTCAAAGGCAGTCGGCTCAACTATGCAGAAAACCTCCTGCGG
CACAAAGAGAATGACAGAGTTGCCCTTTACATTGCAAGGGAAGGCAAAGAGGAAATTGTG
AAGGTGACTTTTGAAGAGCTGAGGCAAGAAGTGGCTTTGTTTGCAGCAGCAATGAGGAAA
ATGGGTGTGAAGAAAGGAGATCGGGTTGTTGGTTATTTACCCAACAGTGAGCACGCTGTC
GAGGCGATGCTGGCTGCGGCAAGCATTGGTGCCATCTGGAGCTCCACGTCCCCGGACTTC
GGTGTGAATGGTGTGCTGGACCGGTTTTCTCAAATTCAGCCAAAGCTCATCTTCTCTGTG
GAGGCTGTTGTCTATAATGGCAAAGAGCACAACCACATGGAAAAGCTGCAGCAGGTGGTT
AAAGGCCTACCAGACTTGAAGAAAGTGGTGGTGATTCCTTATGTGTCCTCCAGAGAGAAC
ATAGACCTTTCAAAGATTCCAAACAGTGTGTTTCTGGATGACTTTCTTGCCACCGGCACC
AGTGAGCAGGCCCCGCAGCTGGAGTTCGAGCAGCTGCCCTTCAGCCACCCACTGTTCATC
ATGTTCTCATCGGGCACCACGGGCGCACCCAAGTGCATGGTGCATTCCGCTGGGGGCACC
CTCATCCAGCATCTGAAGGAGCACCTGCTGCACGGCAACATGACCAGCAGTGACATCCTC
CTGTGCTACACCACGGTCGGCTGGATGATGTGGAACTGGATGGTGTCCCTTCTGGCCACA
GGAGCGGCCATGGTCTTGTACGATGGCTCCCCCCTGGTGCCCACGCCCAATGTGCTCTGG
GACCTGGTTGACAGGATAGGCATCACTGTCCTGGTAACTGGGGCCAAGTGGCTGTCAGTG
CTGGAAGAGAAGGCCATGAAGCCGGTGGAAACCCACAGTCTCCAGATGCTCCACACGATC
CTGTCCACTGGCTCCCCACTGAAAGCCCAGAGCTACGAGTATGTCTACAGGTGCATCAAG
AGCAGCATCCTCCTGGGCTCCATCTCAGGAGGCACCGACATCATCTCCTGCTTCATGGGC
CACAATTTTTCTCTTCCTGTGTATAAAGGGGAGATTCAGGCCCGGAACCTGGGCATGGCC
GTGGAAGCGTGGAACGAGGAAGGAAAGGCGGTCTGGGGAGAGAGCGGCGAGCTGGTGTGT
ACTAAGCCGATCCCTTGCCAGCCCACACACTTCTGGAACGATGAGAACGGCAACAAGTAC
AGGAAGGCGTATTTCTCCAAATTCCCAGGTATCTGGGCTCATGGCGACTACTGCAGAATC
AACCCCAAGACCGGGGGCATCGTCATGCTTGGCCGGAGTGACGGCACCCTCAACCCCAAC
GGGGTGCGGTTCGGCAGCTCGGAAATCTATAACATTGTGGAATCCTTCGAGGAGGTGGAG
GACAGCCTGTGTGTCCCCCAGTATAACAAGTACAGGGAGGAGAGGGTGATCCTCTTCCTG
AAGATGGCCTCCGGGCACGCCTTCCAGCCTGACTTGGTTAAGAGGATCCGTGACGCCATC
CGCATGGGCTTGTCTGCGCGACACGTGCCCAGCCTCATCCTGGAAACCAAGGGCATCCCG
TATACGCTCAACGGCAAGAAAGTGGAAGTTGCCGTCAAACAGATCATCGCTGGAAAAGCC
GTGGAGCAAGGAGGTGCTTTCTCGAACCCCGAGACCCTGGATCTGTACCGGGACATCCCT
GAGCTGCAGGGCTTCTGA

# Metabolic_Enzyme_126_GenBank_ID_Gene:
AL833047

# Metabolic_Enzyme_126_Chromosome_Location:
Not Available

# Metabolic_Enzyme_126_Locus:
Not Available

# Metabolic_Enzyme_126_SNPs:
Not Available

# Metabolic_Enzyme_126_General_References:
Not Available

# Metabolic_Enzyme_126_References:
Not Available

# Metabolic_Enzyme_127_ID:
8813

# Metabolic_Enzyme_127_Name:
Glutamine-dependent NAD(+) synthetase

# Metabolic_Enzyme_127_Synonyms:
NAD(+synthase [glutamine-hydrolyzing]; NAD(+synthetase 1

# Metabolic_Enzyme_127_Gene_Name:
NADSYN1

# Metabolic_Enzyme_127_Protein_Sequence:
>Glutaminedependent NAD+ synthetase
MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYES
DTLLHSFQVLAALVESPVTQDIICDVGMPVMHRNVRYNCRVIFLNRKILLIRPKMALANE
GNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWT
PHSPHIDMGLDGVEIITNASGSHHVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRL
YYDGCAMIAMNGSVFAQGSQFSLDDVEVLTATLDLEDVRSYRAEISSRNLAASRASPYPR
VKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGV
DSAATACLIYSMCCQVCEAVRSGNEEVLADVRTIVNQISYTPQDPRDLCGRILTTCYMAS
KNSSQETCTRARELAQQIGSHHISLNIDPAVKAVMGIFSLVTGKSPLFAAHGGSSRENLA
LQNVQARIRMVLAYLFAQLSLWSRGVHGGLLVLGSANVDESLLGYLTKYDCSSADINPIG
GISKTDLRAFVQFCIQRFQLPALQSILLAPATAELEPLADGQVSQTDEEDMGMTYAELSV
YGKLRKVAKMGPYSMFCKLLGMWRHICTPRQVADKVKRFFSKYSMNRHKMTTLTPAYHAE
NYSPEDNRFDLRPFLYNTSWPWQFRCIENQVLQLERAEPQSLDGVD

# Metabolic_Enzyme_127_Number_of_Residues:
706

# Metabolic_Enzyme_127_Molecular_Weight:
79295

# Metabolic_Enzyme_127_Theoretical_pI:
6.46

# Metabolic_Enzyme_127_GO_Classification:
>>>
 Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Function:  NAD+ synthase (glutamine-hydrolyzing) activity
 ||
>>>
 Process:  nitrogen compound metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  cofactor metabolism
Process:  coenzyme metabolism
Process:  coenzyme biosynthesis
Process:  pyridine nucleotide biosynthesis
Process:  NAD biosynthesis
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_127_General_Function:
Coenzyme transport and metabolism

# Metabolic_Enzyme_127_Specific_Function:
ATP + deamido-NAD(+) + L-glutamine + H(2)O = AMP + diphosphate + NAD(+) + L-glutamate

# Metabolic_Enzyme_127_Pathway:
map00251  Glutamate metabolism
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_127_Reaction:
ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate

# Metabolic_Enzyme_127_Pfam_Domain_Function:
PF00795:CN_hydrolase
PF02540:NAD_synthase

# Metabolic_Enzyme_127_Signals:
Not Available

# Metabolic_Enzyme_127_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_127_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_127_EC_Link:
EC 6.3.5.1

# Metabolic_Enzyme_127_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_127_SwissProt_ID:
NADE1_HUMAN (Q6IA69)

# Metabolic_Enzyme_127_swissprot_Name:
Not Available

# Metabolic_Enzyme_127_Genecard_id:
NADSYN1

# Metabolic_Enzyme_127_Geneatlas_id:
NADSYN1

# Metabolic_Enzyme_127_hgnc_id:
HGNC:29832

# Metabolic_Enzyme_127_PDB_ID:
Not Available

# Metabolic_Enzyme_127_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_127_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_127_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_127_Gene_Sequence:
Not Available

# Metabolic_Enzyme_127_GenBank_ID_Gene:
AB091316

# Metabolic_Enzyme_127_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_127_Locus:
11q13.4

# Metabolic_Enzyme_127_SNPs:
rs2276360; rs7121106; rs12282060; rs35007971; rs2186778; rs2276354; rs11540018; rs1792226; rs4944957; rs732934; rs1792231; rs1540127; rs1790340; rs4402322; rs3794064; rs1893058; rs1792227; rs1790341; rs4944997; rs7129044; rs4944958; rs3814734; rs3814731; rs4944959; rs1792225; rs1790373; rs4944075; rs3794060; rs2017686; rs2276358; rs1792224; rs1790344; rs4423214; rs949178; rs1790339; rs1792316; rs4944955; rs1792229; rs2276361; rs4435028; rs1790343; rs2040323; rs4616066; rs4944956; rs1619577; rs3794062; rs3794057; rs1792235; rs7114525; rs2276362; rs3814733; rs12575605; rs2298776; rs3794067; rs7938885; rs1629220; rs3794061; rs12577807; rs10898203; rs3819215; rs11600569; rs1792234; rs6592154; rs7129099; rs12800438; rs10898210; rs12574206; rs4944076; rs3794065; rs10898193; rs4944998; rs3794068; rs2276353; rs7952035; rs3794059; rs12277408; rs4944062; rs2282619; rs12575622; rs10898211; rs7944926; rs7120029; rs7935125; rs2282618; rs12286616; rs11233747; rs12576621; rs3831470; rs7950778; rs2298773; rs12281892; rs7123973; rs4944979; rs10898191; rs12295554; rs12274363; rs7948770; rs2282617; rs3814732; rs11600355; rs7130038; rs7948898; rs2298772; rs12790558; rs10160536; rs12270619; rs7114825; rs1792319; rs12792306; rs3829251; rs12808368; rs10160376; rs1792315; rs11233789; rs12273154; rs7131218; rs41395047; rs1792233; rs11602942; rs4944063; rs4488226; rs7949129; rs7129788; rs11233901; rs4944999; rs12286569; rs3794063; rs3838792; rs11233754; rs2282620; rs12286997; rs10898201; rs1629304; rs10898186; rs2298775; rs3794066; rs11233746; rs12278461; rs12285168; rs3819214; rs12807718; rs2282621; rs3763860; rs7130479; rs12275636; rs12280406; rs4944064; rs12574554; rs10898200; rs11233933; rs4944996; rs12280295; rs12288906; rs12785878; rs751389; rs2002064; rs11546509; rs11600860; rs11606611; rs2002063; rs11606631; rs11606612; rs7950441; rs35588716; rs35279643; rs3192486; rs34989018; rs12282141; rs12791871; rs10466717; rs7117435; rs11233810; rs11233800; rs4414250; rs34354702; rs35349037; rs35043114; rs11233896; rs7950697; rs7123872; rs35799712; rs35611530; rs12795432; rs35482873; rs34432098; rs7117446; rs35741576; rs10625411; rs12795438; rs12275635; rs12792622; rs7943296; rs12269986; rs34316417; rs35072948; rs11233744; rs11354381; rs2298774; rs12793224; rs1123007; rs3838794; rs12285566; rs2276357; rs7120978; rs12793235; rs10751102; rs11825517; rs1894101; rs35877645; rs34693567; rs12806844; rs7938224; rs28823295; rs7130315; rs10717036; rs2511010; rs10667241; rs12284909; rs28722015; rs11451410; rs3838793; rs7947153; rs34147368; rs35670335; rs12800594; rs1790342; rs34130258; rs12790010; rs35262706; rs12275637; rs11820509; rs35809668; rs35106262; rs3763859; rs36007316; rs35713855; rs11233919; rs10160252; rs11233871; rs34587279; rs10466698; rs12800580; rs2276359; rs35816375; rs12793040; rs7946818; rs12274022; rs34267425; rs12225516; rs34448346; rs34566508; rs11233750; rs35149281; rs11233897; rs12224205; rs2276355; rs12289358; rs1052193; rs7113783; rs7114971; rs753352; rs28898287; rs34753851; rs12794668; rs732935; rs7107444; rs35150568; rs5792561; rs34591259; rs11607157; rs11233902; rs34864556; rs35880452; rs12794647; rs12789751; rs34966057; rs12278475; rs36056023; rs11233868; rs12807827; rs1626291; rs35865105; rs11233947; rs1002171; rs1044482; rs10792743; rs10898223; rs11233977; rs11823940; rs11824413; rs12283114; rs12283185; rs12283407; rs12289036; rs12289074; rs12360674; rs12422045; rs12573951; rs17161531; rs17161576; rs1790334; rs2155425; rs2155428; rs2186777; rs2851691; rs2851692; rs2851693; rs3750997; rs4245442; rs4316537; rs4944946; rs4944949; rs4945007; rs4945008; rs7926054; rs7928249; rs7940244; rs7950584; rs7950649

# Metabolic_Enzyme_127_General_References:
12547821

# Metabolic_Enzyme_127_References:
Not Available

# Metabolic_Enzyme_128_ID:
8856

# Metabolic_Enzyme_128_Name:
Gene with similarity to rat kidney-specific

# Metabolic_Enzyme_128_Synonyms:
KSgene

# Metabolic_Enzyme_128_Gene_Name:
A-923A4.2

# Metabolic_Enzyme_128_Protein_Sequence:
>Gene with similarity to rat kidneyspecific
MKIKPGFMGKATPPYDVQFHMEASVENCIIVSMNTADPGSQGITHSLLLQVIDDKGSILP
PNTEGNIGIRIKPVRPVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSD
DIINASGYRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQL
TKELQQHVKSVTAPYKYPRKVEFVSELPKTITGKIERKELRKKETGQM

# Metabolic_Enzyme_128_Number_of_Residues:
228

# Metabolic_Enzyme_128_Molecular_Weight:
25153

# Metabolic_Enzyme_128_Theoretical_pI:
6.04

# Metabolic_Enzyme_128_GO_Classification:
>>>
 Function:  catalytic activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_128_General_Function:
Lipid transport and metabolism

# Metabolic_Enzyme_128_Specific_Function:
Not Available

# Metabolic_Enzyme_128_Pathway:
Not Available

# Metabolic_Enzyme_128_Reaction:
Not Available

# Metabolic_Enzyme_128_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_128_Signals:
Not Available

# Metabolic_Enzyme_128_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_128_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_128_EC_Link:
EC 6.2.1.2

# Metabolic_Enzyme_128_GenBank_ID_Protein:
3219339

# Metabolic_Enzyme_128_SwissProt_ID:
O75203_HUMAN (O75203)

# Metabolic_Enzyme_128_swissprot_Name:
Not Available

# Metabolic_Enzyme_128_Genecard_id:
A-923A4.2

# Metabolic_Enzyme_128_Geneatlas_id:
A-923A4.2

# Metabolic_Enzyme_128_hgnc_id:
HGNC:18049

# Metabolic_Enzyme_128_PDB_ID:
Not Available

# Metabolic_Enzyme_128_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_128_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_128_Subcellular_Location:
Not Available

# Metabolic_Enzyme_128_Gene_Sequence:
>687 bp
ATGAAGATCAAGCCGGGTTTCATGGGGAAGGCCACTCCACCCTATGACGTCCAGTTTCAT
ATGGAGGCCTCAGTTGAAAACTGCATTATTGTGAGCATGAACACCGCTGACCCTGGCAGC
CAGGGCATCACACACAGCCTCTTGCTACAGGTCATTGATGACAAGGGCAGCATCCTGCCA
CCTAACACAGAAGGAAACATTGGCATCAGAATCAAACCTGTCAGGCCTGTGAGCCTCTTC
ATGTGCTATGAGGGTGACCCAGAGAAGACAGCTAAAGTGGAATGTGGGGACTTCTACAAC
ACTGGGGACAGAGGAAAGATGGATGAAGAGGGCTACATTTGTTTCCTGGGGAGGAGTGAT
GACATCATTAATGCCTCTGGGTATCGCATCGGGCCTGCAGAGGTTGAAAGCGCTTTGGTG
GAGCACCCAGCGGTGGCGGAGTCAGCCGTGGTGGGCAGCCCAGACCCGATTCGAGGGGAG
GTGGTGAAGGCCTTTATTGTCCTGACCCCACAGTTCCTGTCCCATGACAAGGATCAGCTG
ACCAAGGAACTGCAGCAGCATGTCAAGTCAGTGACAGCCCCATACAAGTACCCAAGGAAG
GTGGAGTTTGTCTCAGAGCTGCCAAAAACCATCACTGGCAAGATTGAACGGAAGGAACTT
CGGAAAAAGGAGACTGGTCAGATGTAA

# Metabolic_Enzyme_128_GenBank_ID_Gene:
AC003034

# Metabolic_Enzyme_128_Chromosome_Location:
Not Available

# Metabolic_Enzyme_128_Locus:
Not Available

# Metabolic_Enzyme_128_SNPs:
Not Available

# Metabolic_Enzyme_128_General_References:
10493829

# Metabolic_Enzyme_128_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
5835

# Macromolecular_Interacting_Partner_1_Name:
NEDD8-conjugating enzyme Ubc12

# Macromolecular_Interacting_Partner_1_Synonyms:
Ubiquitin-conjugating enzyme E2 M; NEDD8 protein ligase; NEDD8 carrier protein

# Macromolecular_Interacting_Partner_1_Gene_Name:
UBE2M

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>NEDD8conjugating enzyme Ubc12
MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCDISFSDPDDLLNF
KLVICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWK
PVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFER
CLK

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
183

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
20900

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.84

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Accepts the ubiquitin-like protein NEDD8 from the UBE1C- APPBP1 E1 complex and catalyzes its covalent attachment to other proteins. Involved in cell proliferation

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00179:UQ_con

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
3599674

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
UBC12_HUMAN (P61081)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
UBE2M

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
UBE2M

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:12491

# Macromolecular_Interacting_Partner_1_PDB_ID:
1Y8X

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>552 bp
ATGATCAAGCTGTTCTCGCTGAAGCAGCAGAAGAAGGAGGAGGAGTCGGCGGGCGGCACC
AAGGGCAGCAGCAAGAAGGCGTCGGCGGCGCAGCTGCGGATCCAGAAGGACATAAACGAG
CTGAACCTGCCCAAGACGTGTGATATCAGCTTCTCAGATCCAGACGACCTCCTCAACTTC
AAGCTGGTCATCTGTCCTGATGAGGGCTTCTACAAGAGTGGGAAGTTTGTGTTCAGTTTT
AAGGTGGGCCAGGGTTACCCGCATGATCCCCCCAAGGTGAAGTGTGAGACAATGGTCTAT
CACCCCAACATTGACCTCGAGGGCAACGTCTGCCTCAACATCCTCAGAGAGGACTGGAAG
CCAGTCCTTACGATAAACTCCATAATTTATGGCCTGCAGTATCTCTTCTTGGAGCCCAAC
CCCGAGGACCCACTGAACAAGGAGGCCGCAGAGGTCCTGCAGAACAACCGGCGGCTGTTT
GAGCAGAACGTGCAGCGCTCCATGCGGGGTGGCTACATCGGCTCCACCTACTTTGAGCGC
TGCCTGAAATAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AB012191

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_1_Locus:
19q13.43

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
9694792; 10207026; 10828074

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
5866

# Macromolecular_Interacting_Partner_2_Name:
RNA 3'-terminal phosphate cyclase-like protein

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
RCL1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>RNA 3'terminal phosphate cyclaselike protein
MATQAHSLSYAGCNFLRQRLVLSTLSGRPVKIRKIRARDDNPGLRDFEASFIRLLDKITN
GSRIEINQTGTTLYYQPGLLYGGSVEHDCSVLRGIGYYLESLLCLAPFMKHPLKIVLRGV
TNDQVDPSVDVLKATALPLLKQFGIDGESFELKIVRRGMPPGGGGEVVFSCPVRKVLKPI
QLTDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGVNSGKSPG
FGLSLVAETTSGTFLSAELASNPQGQGAAVLPEDLGRNCARLLLEEIYRGGCVDSTNQSL
ALLLMTLGQQDVSKVLLGPLSPYTIEFLRHLKSFFQIMFKIETKPCGEELKGGDKVLMTC
VGIGFSNLSKTLK

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
373

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
40843

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
9.67

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  cyclase activity
Function:  RNA-3'-phosphate cyclase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
RNA processing and modification 

# Macromolecular_Interacting_Partner_2_Specific_Function:
Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF01137:RTC;
PF05189:RTC_insert

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
7688192

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
RCL1_HUMAN (Q9Y2P8)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
RCL1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
RCL1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:17687

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Nucleus; nucleolus

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1122 bp
ATGGCGACTCAGGCGCACTCCCTCAGCTACGCAGGGTGCAACTTCTTGCGCCAACGTCTG
GTCCTGTCTACCCTGAGCGGGCGCCCCGTCAAAATCCGAAAGATTCGGGCCAGAGACGAC
AACCCGGGCCTCCGAGATTTTGAAGCCAGCTTCATAAGGCTATTGGACAAAATAACGAAT
GGTTCTCGAATTGAAATAAACCAAACAGGAACAACCTTATATTATCAGCCTGGCCTCCTG
TATGGTGGATCTGTGGAACATGACTGTAGCGTCCTTCGTGGCATTGGGTATTACCTGGAG
AGTCTTCTTTGCTTGGCTCCATTTATGAAGCACCCGTTAAAAATAGTTCTACGAGGAGTG
ACCAATGATCAGGTTGACCCTTCAGTTGATGTTCTTAAGGCAACAGCACTCCCTTTGTTG
AAACAATTTGGGATTGATGGTGAATCATTTGAACTGAAGATTGTGCGACGGGGAATGCCT
CCCGGAGGAGGAGGCGAAGTGGTTTTCTCATGTCCTGTGAGGAAGGTCTTGAAGCCCATT
CAACTCACAGATCCAGGAAAAATCAAACGTATTAGAGGAATGGCGTACTCTGTACGTGTG
TCACCTCAGATGGCGAACCGGATTGTGGATTCTGCAAGGAGCATCCTCAACAAGTTCATA
CCTGATATCTATATTTACACAGATCACATGAAAGGAGTCAACTCTGGGAAGTCTCCGGGC
TTTGGGTTGTCACTGGTTGCTGAGACCACCAGTGGCACCTTCCTCAGTGCTGAACTGGCC
TCCAACCCCCAGGGCCAGGGAGCAGCAGTACTTCCAGAGGACCTTGGCAGGAACTGTGCC
CGGCTGCTGCTGGAGGAAATCTACAGGGGTGGATGCGTAGACTCGACCAACCAAAGCCTG
GCGCTACTACTCATGACCCTTGGACAGCGGGATGTTTCCAAAGTCCTGCTAGGCCCTCTC
TCTCCCTACACGATAGAATTTTTGCGGCATTTGAAGAGCTTTTTCCAGATTATGTTTAAA
ATTGAAACCAAGCCATGTGGTGAAGAACTCAAGGGTGGGGATAAAGTGCTGATGACCTGT
GTTGGCATTGGTTTCTCCAACCTTAGCAAGACCCTCAAGTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AJ276894

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Locus:
Not Available

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
10790377; 11042152

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
5907

# Macromolecular_Interacting_Partner_3_Name:
SUMO-conjugating enzyme UBC9

# Macromolecular_Interacting_Partner_3_Synonyms:
SUMO-protein ligase; Ubiquitin-conjugating enzyme E2 I; Ubiquitin-protein ligase I; Ubiquitin carrier protein I; Ubiquitin carrier protein 9; p18

# Macromolecular_Interacting_Partner_3_Gene_Name:
UBE2I

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>SUMOconjugating enzyme UBC9
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKL
RMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELL
NEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
158

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
18007

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
8.90

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00179:UQ_con

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
1296801

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
UBC9_HUMAN (P63279)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
UBE2I

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
UBE2I

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:12485

# Macromolecular_Interacting_Partner_3_PDB_ID:
1KPS

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>477 bp
ATGTCGGGGATCGCCCTCAGCAGACTCGCCCAGGAGAGGAAAGCATGGAGGAAAGACCAC
CCATTTGGTTTCGTGGCTGTCCCAACAAAAAATCCCGATGGCACGATGAACCTCATGAAC
TGGGAGTGCGCCATTCCAGGAAAGAAAGGGACTCCGTGGGAAGGAGGCTTGTTTAAACTA
CGGATGCTTTTCAAAGATGATTATCCATCTTCGCCACCAAAATGTAAATTCGAACCACCA
TTATTTCACCCGAATGTGTACCCTTCGGGGACAGTGTGCCTGTCCATCTTAGAGGAGGAC
AAGGACTGGAGGCCAGCCATCACAATCAAACAGATCCTATTAGGAATACAGGAACTTCTA
AATGAACCAAATATCCAAGACCCAGCTCAAGCAGAGGCCTACACGATTTACTGCCAAAAC
AGAGTGGAGTACGAGAAAAGGGTCCGAGCACAAGCCAAGAAGTTTGCGCCCTCATAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
X96427

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_3_Locus:
16p13.3

# Macromolecular_Interacting_Partner_3_SNPs:
rs3169412; rs8063; rs8047332; rs7302; rs6600134; rs9926183; rs9597; rs8062854; rs9926094; rs6600135; rs8062881; rs12102342; rs2268049; rs8052688; rs4017713; rs12446893; rs8053875; rs4017714; rs11248866; rs2281226; rs2369842; rs761060; rs761058; rs761059; rs4984806; rs8062227; rs4017786; rs4984808; rs909916; rs2369700; rs909915; rs8058975; rs909917; rs8046527; rs12447051; rs11648216; rs8063596; rs17135320; rs7202125; rs8045459; rs8063770; rs8044721; rs11648215; rs11647760; rs4984809; rs11248868; rs9933497; rs11648562; rs8043720; rs2235633; rs8050313; rs9328917; rs11645809; rs11644706; rs11553473; rs2281225; rs11553471; rs2230152; rs8060742; rs11553472; rs8057293; rs8053263; rs4984805; rs35636012; rs34122288; rs12102374; rs33974350; rs8046903; rs5815088; rs10547297; rs12926261; rs35840411; rs8062442; rs8056919; rs10903004; rs12129; rs1575040; rs12920764; rs4638578; rs12103099; rs7198283; rs9928135; rs34689784; rs9673771; rs3078791; rs28631092; rs909919; rs5815089; rs8048776; rs34122945; rs35756062; rs7186045; rs11321641; rs4984807; rs8051743; rs35143301; rs28510571; rs33913982; rs11643527; rs9941160; rs7190309; rs28867488; rs34139034; rs909918; rs4984810; rs12927902; rs11248867; rs8046847; rs11274233; rs12449104; rs7195339; rs8060456; rs34839745; rs10677849; rs12927901; rs34342091; rs12918274; rs33983021; rs12444610; rs2982430; rs28457180; rs2974842; rs28971051; rs2974843; rs12933428; rs12930585; rs2982429; rs1061614; rs1061619; rs1061621; rs1061633; rs11248865; rs12925270; rs1883561; rs34250044; rs35702607; rs3759936; rs3759937; rs4261539; rs4984803; rs4984804; rs4984811; rs4984813; rs6600128; rs6600129; rs710902; rs7187167; rs7195012; rs7204003; rs731046; rs761061; rs761062; rs761063; rs761064; rs8048759; rs909914

# Macromolecular_Interacting_Partner_3_General_References:
8668529; 9067428; 8565643; 8668125; 8798754; 9333025; 11157797; 8824223; 9334332; 9261152

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
7549

# Macromolecular_Interacting_Partner_4_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
INS

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_4_Signals:
1-24

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
INS

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_4_Locus:
11p15.5

# Macromolecular_Interacting_Partner_4_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_4_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_4_References:
15930957

# Macromolecular_Interacting_Partner_5_ID:
7551

# Macromolecular_Interacting_Partner_5_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_5_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_5_Locus:
6p21.3

# Macromolecular_Interacting_Partner_5_SNPs:
Not Available

# Macromolecular_Interacting_Partner_5_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_5_References:
16357326; 16419651

# Macromolecular_Interacting_Partner_6_ID:
7615

# Macromolecular_Interacting_Partner_6_Name:
cAMP response element-binding protein

# Macromolecular_Interacting_Partner_6_Synonyms:
CREB

# Macromolecular_Interacting_Partner_6_Gene_Name:
CREB1

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>cAMP response elementbinding protein
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN
GQTVQVHGVIQAAQPSVIQSPQVQTVQSSCKDLKRLFSGTQISTIAESEDSQESVDSVTD
SQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSG
QYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQV
VVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAAREC
RRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
341

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
36688

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
5.24

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  protein binding
Function:  transcription factor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00170:bZIP_1;
PF02173:pKID

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
240429

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
CREB1_HUMAN (P16220)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
CREB1

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
CREB1

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:2345

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>984 bp
ATGACCATGGAATCTGGAGCCGAGAACCAGCAGAGTGGAGATGCAGCTGTAACAGAAGCT
GAAAACCAACAAATGACAGTTCAAGCCCAGCCACAGATTGCCACATTAGCCCAGGTATCT
ATGCCAGCAGCTCATGCAACATCATCTGCTCCCACCGTAACTCTAGTACAGCTGCCCAAT
GGGCAGACAGTTCAAGTCCATGGAGTCATTCAGGCGGCCCAGCCATCAGTTATTCAGTCT
CCACAAGTCCAAACAGTTCAGATTTCAACTATTGCAGAAAGTGAAGATTCACAGGAGTCA
GTGGATAGTGTAACTGATTCCCAAAAGCGAAGGGAAATTCTTTCAAGGAGGCCTTCCTAC
AGGAAAATTTTGAATGACTTATCTTCTGATGCACCAGGAGTGCCAAGGATTGAAGAAGAG
AAGTCTGAAGAGGAGACTTCAGCACCTGCCATCACCACTGTAACGGTGCCAACTCCAATT
TACCAAACTAGCAGTGGACAGTATATTGCCATTACCCAGGGAGGAGCAATACAGCTGGCT
AACAATGGTACCGATGGGGTACAGGGCCTGCAAACATTAACCATGACCAATGCAGCAGCC
ACTCAGCCGGGTACTACCATTCTACAGTATGCACAGACCACTGATGGACAGCAGATCTTA
GTGCCCAGCAACCAAGTTGTTGTTCAAGCTGCCTCTGGAGACGTACAAACATACCAGATT
CGCACAGCACCCACTAGCACTATTGCCCCTGGAGTTGTTATGGCATCCTCCCCAGCACTT
CCTACACAGCCTGCTGAAGAAGCAGCACGAAAGAGAGAGGTCCGTCTAATGAAGAACAGG
GAAGCAGCTCGAGAGTGTCGTAGAAAGAAGAAAGAATATGTGAAATGTTTAGAAAACAGA
GTGGCAGTGCTTGAAAATCAAAACAAGACATTGATTGAGGAGCTAAAAGCACTTAAGGAC
CTTTACTGCCACAAATCAGATTAA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
S72459

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_6_Locus:
2q34

# Macromolecular_Interacting_Partner_6_SNPs:
rs2709357; rs2709356; rs889895; rs2551917; rs2709400; rs2551640; rs2709360; rs2042486; rs2551642; rs4675682; rs2709359; rs2551639; rs11883511; rs7590024; rs2709355; rs2551641; rs2709398; rs2360970; rs2042485; rs12466352; rs2709399; rs2709387; rs2551920; rs2551923; rs2464978; rs6740584; rs2254137; rs2551921; rs2551919; rs9679258; rs9288383; rs3770704; rs13397461; rs12694087; rs2551922; rs16839883; rs2194430; rs11904814; rs2709393; rs3730300; rs2247053; rs10199872; rs2551924; rs2551644; rs2059336; rs17811997; rs7603049; rs11692041; rs7570673; rs3730276; rs13393250; rs2551645; rs2709402; rs2709388; rs2464977; rs17515722; rs2551926; rs13398837; rs10932201; rs2952766; rs12477957; rs2709392; rs2464976; rs2551638; rs35349697; rs34884247; rs35342276; rs12992351; rs12467170; rs13422727; rs13016095; rs10561230; rs10202862; rs35952037; rs35924297; rs35303892; rs3836057; rs1050641; rs2709354; rs35153918; rs4024317; rs35539388; rs11356093; rs12998737; rs11397523; rs35506841; rs9677382; rs35379208; rs12992752; rs12470697; rs13029939; rs12467171; rs13422622; rs35711096; rs35714520; rs34172985; rs10598911; rs4024318; rs35004775; rs3836058; rs10568689; rs13422714; rs35282925; rs35047346; rs34797824; rs7582473; rs35896795; rs6729764; rs12614101; rs7603975; rs2709385; rs13018430; rs34411431; rs2709403; rs34628133; rs2551647; rs7589804; rs34775277; rs35762508; rs2551646; rs28853093; rs17515729; rs13431009; rs2551918; rs7558859; rs34583259; rs2551648; rs34550164; rs2551925; rs6715664; rs2709404; rs35735523; rs7576411; rs4101544; rs34903544; rs3951781; rs34242417; rs1064176; rs4675684; rs6705627; rs11311967; rs13412269; rs34309640; rs10185283; rs11684107; rs36108540; rs35955521; rs5838079; rs35019306; rs35728983; rs2709389; rs34275460; rs34379142; rs2709362; rs35000643; rs35261053; rs35119018; rs13409275; rs2709381; rs34177886; rs12478868; rs34145676; rs2709378; rs2551643; rs7588606; rs34127936; rs35865443; rs12998128; rs2709377; rs11319861; rs11335782; rs35907148; rs34317727; rs35318842; rs1045780; rs1045790; rs12999688; rs13029936; rs13386109; rs1806584; rs1806585; rs2551928; rs2551931; rs2709371; rs2709373; rs2709374; rs2709376; rs2709396; rs6785; rs7569963

# Macromolecular_Interacting_Partner_6_General_References:
2142528; 2196176; 1966745; 2974179; 1831258; 8381074; 7608156

# Macromolecular_Interacting_Partner_6_References:
16143450; 16164634; 16234845; 16240350

# Macromolecular_Interacting_Partner_7_ID:
8405

# Macromolecular_Interacting_Partner_7_Name:
Hypothetical protein

# Macromolecular_Interacting_Partner_7_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Hypothetical protein
MLFKAYMYLNEGQKLLKTLKKDKSWSQTFESATFYSLKGEVCFNMGQIVLAKKMLRKALK
LLNRIFPYNLISLFLHIHVEKNRHFHYVNRQAQESPPPGKKRLAQLYRQTVCLSLLWRIY
SYSYLFHCKYYAHLAVMMQMNTALETQNCFQIIKAYLDYSLYHHLAGYKGVWFKYEVMAM
EHIFNLPLKGEGIEIVAYVAETLVFNKLIMGHLDLAIELGSRALQMWALLQNPNRHYQSL
CRLSRCLLLNSRYPQLIQVLGRLWELSVTQEHIFSKAFFYFVCLDILLYSGFVYRTFEEC
LEFIHQYENNRILKFHSGLLLGLYSSVAIWECEAGVGRRLHTSRDPGMPDFRNGTTFTNF
PIELKIFCQEEP

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
372

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
43901

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
9.26

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
EC 4.6.1.1

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
4153951

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
O95558_HUMAN (O95558)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_7_hgnc_id:
Not Available

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1119 bp
ATGCTGTTCAAGGCATACATGTATTTGAATGAAGGACAGAAGTTGCTAAAAACTCTCAAG
AAGGACAAATCTTGGAGCCAGACATTTGAGTCTGCCACCTTTTACAGCCTCAAAGGTGAG
GTCTGTTTCAATATGGGCCAGATAGTGCTTGCCAAGAAAATGCTGAGGAAGGCACTGAAG
CTCCTCAACCGAATCTTTCCTTACAACTTAATCTCCTTGTTTCTCCATATCCATGTCGAG
AAAAACAGACACTTTCATTATGTGAATCGGCAGGCCCAAGAGAGCCCACCTCCAGGGAAG
AAGAGGCTGGCACAACTTTACCGGCAAACTGTCTGCCTTTCCTTGCTGTGGCGCATCTAT
AGCTACAGTTATCTTTTTCACTGCAAGTATTATGCCCACCTGGCAGTTATGATGCAAATG
AATACTGCACTGGAAACTCAAAATTGTTTCCAGATCATTAAGGCTTACCTAGACTATTCG
CTATACCACCACCTGGCTGGCTACAAAGGTGTGTGGTTCAAATATGAAGTCATGGCCATG
GAGCACATCTTCAACCTCCCCCTGAAAGGCGAGGGCATTGAAATCGTGGCATACGTGGCT
GAGACACTGGTCTTCAACAAGCTCATAATGGGACACCTGGATTTGGCCATTGAGTTAGGC
TCCCGAGCCCTTCAGATGTGGGCACTGCTCCAGAATCCCAACCGACATTATCAGTCCCTC
TGCAGACTTAGCAGATGTCTCCTTCTGAACAGCAGATACCCGCAATTGATCCAGGTGCTG
GGGCGGCTGTGGGAGCTTTCTGTAACACAGGAACACATCTTCAGCAAGGCATTTTTCTAT
TTTGTCTGCTTGGACATCCTGCTTTATTCTGGTTTTGTTTATAGAACATTTGAAGAATGT
TTGGAATTCATACACCAATACGAAAACAACAGAATCCTCAAGTTCCACAGTGGACTCCTC
CTGGGACTTTATTCCTCTGTAGCTATCTGGGAGTGTGAAGCAGGGGTAGGCAGGAGACTA
CACACTTCCAGAGACCCAGGTATGCCAGACTTCAGGAATGGGACAACTTTTACAAATTTT
CCAATAGAGCTAAAAATCTTTTGCCAAGAAGAACCATGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
AL035122

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Locus:
Not Available

# Macromolecular_Interacting_Partner_7_SNPs:
Not Available

# Macromolecular_Interacting_Partner_7_General_References:
Not Available

# Macromolecular_Interacting_Partner_7_References:
16098598; 16517146; 16527269

# Macromolecular_Interacting_Partner_8_ID:
7839

# Macromolecular_Interacting_Partner_8_Name:
5'-AMP-activated protein kinase subunit beta-1

# Macromolecular_Interacting_Partner_8_Synonyms:
AMPK beta-1 chain; AMPKb

# Macromolecular_Interacting_Partner_8_Gene_Name:
PRKAB1

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>5'AMPactivated protein kinase subunit beta1
MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEF
LAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPE
GEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELS
SSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLY
ALSIKDGVMVLSATHRYKKKYVTTLLYKPI

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
270

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
30383

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
6.37

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone- sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adaptor molecule for the catalytic alpha-subunit

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF04739:AMPKBI;
PF02922:Isoamylase_N

# Macromolecular_Interacting_Partner_8_Signals:
None

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
2916800

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
AAKB1_HUMAN (Q9Y478)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
PRKAB1

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
PRKAB1

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:9378

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>813 bp
ATGGGCAATACCAGCAGTGAGAGGGCGGCGCTGGAGCGGCATGCTGGCCATAAGACGCCC
CGGAGGGACAGCTCGGGGGGCACCAAGGACGGGGACAGGCCCAAGATCCTGATGGACAGC
CCCGAAGACGCCGACCTCTTCCACTCCGAGGAAATCAAGGCACCAGAGAAGGAGGAATTC
CTGGCCTGGCAGCATGATCTGGAAGTGAATGATAAAGCTCCCGCCCAGGCTCGGCCAACG
GTGTTTCGATGGACGGGGGGCGGAAAGGAAGTTTACTTATCTGGGTCCTTCAACAACTGG
AGTAAACTTCCCCTCACCAGAAGCCACAATAACTTTGTAGCCATCCTGGATCTGCCGGAA
GGAGAGCATCAGTACAAGTTCTTTGTGGATGGTCAGTGGACGCACGACCCTTCCGAGCCC
ATAGTAACCAGCCAGCTTGGCACAGTTAACAACATAATTCAAGTGAAGAAAACTGACTTT
GAGGTATTTGATGCTTTAATGGTGGATTCCCAAAAGTGCTCCGATGTGTCTGAGCTGTCC
AGTTCTCCCCCAGGACCCTACCATCAGGAGCCCTACGTCTGCAAACCCGAAGAGCGCTTT
CGGGCACCCCCTATTCTCCCCCCACATCTCCTCCAGGTCATCCTGAACAAGGACACGGGG
ATTTCCTGTGATCCAGCTTTGCTTCCTGAGCCCAATCACGTCATGCTGAACCACCTATAC
GCGCTGTCTATCAAGGATGGAGTGATGGTGCTCAGCGCAACCCACCGGTACAAGAAGAAG
TACGTCACCACCTTGTTATACAAGCCCATATGA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
AJ224515

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_8_Locus:
12q24.1

# Macromolecular_Interacting_Partner_8_SNPs:
rs4213; rs278148; rs278147; rs278149; rs278152; rs278143; rs6490267; rs278144; rs278145; rs10849690; rs17408578; rs278151; rs12314027; rs12304635; rs6490266; rs3759400; rs6490265; rs11064873; rs11546695; rs1043354; rs1062688; rs1043350; rs1043352; rs11064876; rs3182909; rs35934503; rs278146; rs278150; rs34309696; rs7312687; rs3999587; rs34549847; rs2285593; rs11832628; rs11064874; rs7953470; rs11064875; rs34516378; rs35524914; rs34062789; rs10774512; rs11064877; rs12305216; rs12425960; rs175878; rs1978107; rs1978108; rs2393550; rs278122; rs278123; rs278155; rs3742046; rs3930004; rs7300583; rs7310266; rs7953776; rs7960723

# Macromolecular_Interacting_Partner_8_General_References:
9224708

# Macromolecular_Interacting_Partner_8_References:
16151020; 16308421; 16434692; 16513051

# Macromolecular_Interacting_Partner_9_ID:
8529

# Macromolecular_Interacting_Partner_9_Name:
Novel protein

# Macromolecular_Interacting_Partner_9_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_9_Gene_Name:
RP11-163G10.1

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Novel protein
MFYLAAAVSDFYVPVSEMPEHKIQSSGGPLQITMKMVPKLLSPLVKDWAPKAFIISFKLE
TDPAIVINRARKALEIYQHQVVVANILESRQSFVFIVTKDSETKLLLSEEEIEKGVEIEE
KIVDNLQSRHTAFIGDRN

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
138

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
15645

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
5.71

# Macromolecular_Interacting_Partner_9_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_9_General_Function:
Coenzyme transport and metabolism

# Macromolecular_Interacting_Partner_9_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF04127:DFP

# Macromolecular_Interacting_Partner_9_Signals:
Not Available

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
55665116

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
Q5VVM0_HUMAN (Q5VVM0)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
RP11-163G10.1

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
RP11-163G10.1

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:25686

# Macromolecular_Interacting_Partner_9_PDB_ID:
1P9O

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>936 bp
ATGGCGGAAATGGATCCGGTAGCCGAGTTCCCCCAGCCTCCCGGTGCTGCGCGCTGGGCT
GAGGTTATGGCTCGCTTCGCGGCCAGGCTGGGCGCGCAGGGCCGGCGGGTGGTGTTGGTT
ACGTCAGGCGGCACCAAGGTCCCACTGGAAGCGCGGCCGGTGCGCTTCCTGGACAACTTC
AGCAGCGGGCGGCGCGGTGCAACCTCGGCCGAGGCCTTCCTAGCCGCCGGCTACGGGGTC
CTGTTCTTGTATCGCGCTCGCTCTGCCTTCCCCTATGCCCACCGCTTCCCACCCCAGACT
TGGCTGTCCGCTCTGCGGCCTTCGGGCCCAGCCCTTTCGGGCTTGCTGAGCCTGGAGGCC
GAGGAGAATGCACTTCCGGGTTTTGCTGAGGCTCTGAGGAGCTACCAGGAGGCTGCGGCT
GCAGGCACCTTCCTGGCAGTAGAGTTCACCACTTTGGCGGACTATTTGCATCTGTTGCAG
GCTGCGGCCCAGGCACTCAATCCGCTAGGCCCTTCTGCGATGTTTTACCTGGCTGCGGCT
GTGTCAGATTTCTATGTTCCTGTCTCTGAAATGCCTGAACACAAGATCCAGTCATCTGGG
GGCCCACTGCAGATAACAATGAAGATGGTGCCAAAACTGCTTTCTCCTTTGGTTAAAGAT
TGGGCTCCCAAAGCATTTATAATTTCCTTTAAGTTGGAGACTGACCCCGCCATTGTAATT
AATCGAGCTCGGAAGGCTTTGGAAATTTATCAGCATCAAGTGGTGGTGGCTAATATCCTT
GAGTCACGACAGTCCTTTGTGTTTATTGTAACCAAAGACTCGGAAACCAAGTTATTGCTA
TCAGAGGAAGAAATAGAAAAAGGCGTAGAGATAGAAGAGAAGATAGTGGATAATCTTCAG
TCTCGACACACAGCTTTTATAGGTGACAGAAACTGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
AL445669

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_9_Locus:
Not Available

# Macromolecular_Interacting_Partner_9_SNPs:
Not Available

# Macromolecular_Interacting_Partner_9_General_References:
Not Available

# Macromolecular_Interacting_Partner_9_References:
Not Available

# Macromolecular_Interacting_Partner_10_ID:
8595

# Macromolecular_Interacting_Partner_10_Name:
IL-6SAG

# Macromolecular_Interacting_Partner_10_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_10_Gene_Name:
IL-6SAG

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>IL6
SAGESQRRRSPCQPFIGSGTHEVQLVPGTVHSLKQLKGLSPDTDATLSRMHGPGLTLSME
EVGSARGGRMVARDTESLVLGLWPS

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
82

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
8796

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
8.56

# Macromolecular_Interacting_Partner_10_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Signals:
Not Available

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
3065755

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
O60670_HUMAN (O60670)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
IL-6SAG

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
IL-6SAG

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:3368

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>250 bp
GGAATCCCAGAGAAGGAGAAGCCCCTGTCAACCTTTTATTGGGAGTGGAACACATGAGGT
TCAGCTCGTGCCGGGCACTGTACATTCACTGAAGCAGCTCAAGGGGCTCAGCCCCGACAC
TGACGCCACACTGAGCAGGATGCACGGCCCGGGGCTCACACTGTCCATGGAGGAGGTGGG
GTCAGCCCGAGGTGGGCGGATGGTGGCCCGAGACACCGAGAGCTTGGTTCTGGGACTGTG
GCCCAGCTGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
AF058296

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_10_Locus:
Not Available

# Macromolecular_Interacting_Partner_10_SNPs:
Not Available

# Macromolecular_Interacting_Partner_10_General_References:
Not Available

# Macromolecular_Interacting_Partner_10_References:
Not Available

# Macromolecular_Interacting_Partner_11_ID:
8651

# Macromolecular_Interacting_Partner_11_Name:
OTTHUMP00000030471

# Macromolecular_Interacting_Partner_11_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_11_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>
OTTHUMP00000030471MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPS
GSAPAVAAAAAQPGSYPALSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGW
FLGGQLNVSVNCLDQHVRKSPESVALIWERDEPGTEVRITYSPWLQMPCGP

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
16137

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
8.66

# Macromolecular_Interacting_Partner_11_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_11_General_Function:
Lipid transport and metabolism

# Macromolecular_Interacting_Partner_11_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Signals:
Not Available

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
Q5TF43_HUMAN (Q5TF43)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
ACSS1

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
ACSS1

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:16091

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
AL080312

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_11_Locus:
Not Available

# Macromolecular_Interacting_Partner_11_SNPs:
Not Available

# Macromolecular_Interacting_Partner_11_General_References:
Not Available

# Macromolecular_Interacting_Partner_11_References:
Not Available

# Macromolecular_Interacting_Partner_12_ID:
8797

# Macromolecular_Interacting_Partner_12_Name:
Hypothetical protein PDE11A

# Macromolecular_Interacting_Partner_12_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_12_Gene_Name:
PDE11A

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Hypothetical protein PDE11
AVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQT
LLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAEN

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
98

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
11231

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
5.19

# Macromolecular_Interacting_Partner_12_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Signals:
Not Available

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
62988743

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
Q53S07_HUMAN (Q53S07)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
PDE11A

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
PDE11A

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:8773

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>296 bp
GTTATGCAGATGTATCTTCCATTTTGTGGAATCGCCATATCTAACGCTCAGCTCTTTGCT
GCCTCAAGGAAAGAATATGAAAGAAGCAGAGCTTTGCTAGAGGTGGTTAATGACCTCTTT
GAAGAACAGACTGACCTGGAGAAAATTGTCAAGAAAATAATGCATCGGGCCCAAACTCTG
CTGAAATGTGAACGCTGTTCTGTTTTACTCCTAGAGGACATCGAATCACCAGTGGTGAAA
TTTACCAAATCCTTTGAATTGATGTCCCCAAAGTGCAGTGCTGATGCTGAGAACAG

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
AC073892

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_12_Locus:
2q31.2

# Macromolecular_Interacting_Partner_12_SNPs:
rs6705405; rs6734426; rs6734528; rs6734683; rs13034886; rs13010396; rs1438035; rs966433; rs1852503; rs1866212; rs1561316; rs2573088; rs941271; rs2886498; rs2695743; rs2365889; rs1465830; rs1469973; rs1438046; rs1880916; rs2573082; rs1982131; rs934798; rs2695760; rs1370662; rs1347731; rs1561319; rs1405650; rs2252726; rs2695109; rs1438054; rs1546813; rs1405646; rs1469972; rs1358326; rs1997208; rs2695099; rs1527399; rs1438063; rs1821628; rs2164860; rs1527293; rs1997206; rs1358327; rs1997207; rs2573083; rs1534290; rs1544001; rs1405651; rs1370661; rs2695740; rs1004541; rs934809; rs2118482; rs1370656; rs2037757; rs1344925; rs744397; rs1405647; rs753346; rs2060490; rs1347441; rs959157; rs1438038; rs2222711; rs1344922; rs744398; rs934803; rs1405648; rs1438037; rs2695098; rs1438051; rs1534289; rs1438048; rs934802; rs3770044; rs10497478; rs9288011; rs1344923; rs10170290; rs2695757; rs3108476; rs2695115; rs7583817; rs1866211; rs1527294; rs1369519; rs2020213; rs12693147; rs4893844; rs1106074; rs6433694; rs4893975; rs10497483; rs2695735; rs2573087; rs3108453; rs3770034; rs714528; rs4893980; rs998059; rs7560514; rs4413189; rs2695097; rs3770009; rs2573079; rs2886499; rs10198681; rs6746845; rs7563242; rs7606084; rs6433691; rs6760930; rs10198111; rs7570423; rs3770023; rs6737254; rs2043546; rs6718702; rs7573755; rs1370663; rs1020010; rs1370658; rs6433705; rs2695738; rs6433708; rs1438064; rs2695741; rs7588973; rs6433698; rs6749088; rs1561320; rs7605493; rs1527292; rs1991994; rs13421315; rs4893994; rs6721360; rs7570981; rs6433710; rs7588062; rs2886651; rs2695728; rs3770045; rs7600368; rs11684634; rs3770051; rs3754996; rs7586934; rs7578325; rs1465831; rs7605091; rs13026481; rs6758442; rs12693133; rs10186239; rs3770007; rs7573622; rs9679090; rs10930820; rs1405649; rs2217839; rs1527410; rs12693128; rs5025340; rs6726321; rs13389574; rs3910519; rs7591796; rs1435573; rs4893839; rs7569984; rs1527400; rs6718860; rs2695104; rs6745743; rs2695756; rs1898012; rs4893840; rs6758543; rs1344916; rs1830209; rs1438039; rs6738614; rs1997209; rs2043548; rs1527291; rs10198877; rs3951527; rs6726477; rs1527401; rs7591897; rs6433695; rs941274; rs6734520; rs1866209; rs7598623; rs959792; rs1369520; rs13026012; rs7595479; rs1004542; rs1527407; rs9288009; rs2365895; rs2695724; rs13429220; rs4893972; rs4522644; rs2695746; rs7557283; rs10207459; rs7559765; rs6708869; rs2886424; rs1438040; rs6720891; rs1946814; rs6741976; rs6733229; rs6743821; rs7608073; rs1527295; rs12693151; rs1866210; rs6737872; rs6433693; rs6750238; rs10930814; rs13428806; rs6751656; rs3770003; rs934804; rs12693127; rs6760512; rs6433709; rs2573085; rs10174604; rs2033762; rs6718657; rs2695103; rs3770018; rs10497493; rs6745288; rs1530035; rs1435574; rs1438049; rs4893985; rs10192481; rs6757651; rs10201180; rs11887429; rs1527296; rs4335982; rs2695112; rs2222712; rs880899; rs13009350; rs2695091; rs12990719; rs3821010; rs1527405; rs7605757; rs10497482; rs13402629; rs16865524; rs10189134; rs10497485; rs17635934; rs2015183; rs3731809; rs2033763; rs12693148; rs2695111; rs1358328; rs732363; rs12468127; rs10221806; rs6756994; rs12616259; rs1438045; rs1898585; rs12693146; rs6705118; rs2099476; rs13412319; rs13431084; rs12619453; rs12612171; rs13017429; rs6740251; rs6714519; rs4893995; rs13008780; rs1975323; rs2886500; rs2366352; rs7594290; rs12693123; rs7575322; rs6716496; rs10497494; rs13426862; rs10221783; rs17400325; rs11695452; rs13386639; rs1816520; rs6433685; rs6729482; rs3770015; rs7578901; rs11889185; rs13028757; rs1317945; rs9808399; rs4144275; rs2365896; rs1405718; rs17329956; rs1530034; rs11674668; rs17400505; rs7584946; rs6724986; rs13034781; rs3770047; rs12693145; rs6759712; rs10497479; rs4468852; rs12612509; rs13030747; rs3821007; rs4893987; rs10930805; rs1370655; rs12994494; rs17635957; rs2695094; rs880898; rs13390014; rs2573080; rs6433688; rs2695730; rs11883602; rs3770016; rs13389525; rs16866032; rs7568068; rs4337505; rs13017473; rs934801; rs12475250; rs13025391; rs4423634; rs16865995; rs17401468; rs17330172; rs6433711; rs1405645; rs12693130; rs10497495; rs4144276; rs10754990; rs16865872; rs2033760; rs16865498; rs11677821; rs12478277; rs11904461; rs13396537; rs10168641; rs11886258; rs13427906; rs11680652; rs10175364; rs16865645; rs10164920; rs3770050; rs13402636; rs2695729; rs13022684; rs1527402; rs7560080; rs2033761; rs6752264; rs12618542; rs10190805; rs12618537; rs17636610; rs13003683; rs1469971; rs17401650; rs4893976; rs4893988; rs10497480; rs10201150; rs13032794; rs934800; rs10191328; rs11903134; rs880897; rs6705472; rs12471621; rs12987101; rs6753870; rs10178985; rs2365625; rs16865492; rs17400931; rs1866215; rs10165396; rs6759109; rs1547580; rs13411922; rs2695732; rs13426284; rs6752409; rs13405585; rs6756240; rs4541282; rs3731808; rs3770008; rs2365619; rs1561318; rs17329742; rs16865906; rs16865604; rs17635803; rs4567975; rs3770005; rs6709256; rs6717171; rs10202985; rs16865535; rs10180052; rs10174066; rs3754993; rs12693149; rs10497496; rs10497486; rs13427960; rs2366353; rs2695737; rs2164859; rs3108451; rs10194370; rs10171486; rs7422544; rs6433697; rs11892557; rs1865588; rs1438062; rs6733980; rs6746482; rs13392051; rs2695742; rs2091442; rs6739583; rs6750869; rs13419437; rs1527403; rs1866208; rs10197020; rs6726502; rs6433690; rs7422960; rs1547581; rs4893981; rs1898013; rs13429445; rs12612481; rs2164857; rs11686720; rs6712082; rs4243392; rs13410185; rs16866042; rs3770011; rs16865503; rs1837163; rs17329998; rs10211057; rs12151755; rs12613207; rs11679730; rs7604345; rs7591800; rs16865494; rs1358299; rs4470372; rs10497488; rs6736927; rs7567851; rs941276; rs9677333; rs7421260; rs10930809; rs6707034; rs10202989; rs3770048; rs934806; rs12693129; rs7597640; rs3915272; rs10208501; rs12693143; rs11678875; rs17400512; rs7588301; rs17687170; rs11687117; rs12616321; rs13025904; rs1821629; rs13008170; rs6715232; rs12995449; rs13425873; rs2695725; rs3770035; rs3770028; rs3821009; rs11680632; rs3770012; rs10192225; rs1837164; rs13015148; rs12618150; rs10170914; rs11896183; rs4893989; rs1527288; rs3770019; rs10172800; rs17401293; rs6704720; rs13017234; rs12693150; rs11904417; rs7562835; rs13386418; rs1946813; rs7559596; rs11690740; rs10175970; rs16865825; rs4341975; rs11687543; rs13009207; rs2886653; rs12463866; rs13017026; rs6755503; rs4893979; rs17401860; rs12693142; rs16865901; rs17402102; rs3821008; rs16865703; rs998060; rs7577552; rs6718206; rs10930815; rs10497487; rs13398310; rs4446096; rs12469388; rs2164858; rs11892483; rs7566399; rs6713981; rs1438060; rs4110134; rs17400121; rs6748696; rs3770053; rs13022805; rs7558310; rs12693131; rs3754991; rs7573345; rs7595951; rs10183144; rs10497492; rs2365620; rs10170607; rs7561059; rs10171247; rs1405716; rs1544003; rs749208; rs6718993; rs13398604; rs10197329; rs13003047; rs7593753; rs999218; rs1106075; rs10210259; rs3770010; rs1370657; rs6708025; rs1025598; rs12618596; rs1435575; rs12473461; rs934808; rs6709966; rs11674299; rs934799; rs959775; rs1370664; rs13000926; rs11893349; rs11883778; rs1544002; rs4893984; rs13411542; rs10497490; rs16865819; rs17330290; rs2117740; rs6756606; rs7579625; rs1554776; rs10497484; rs16865756; rs10191015; rs1405714; rs17401902; rs16866000; rs749207; rs7605744; rs4893847; rs11891283; rs12619506; rs2695092; rs13014883; rs2360221; rs17687590; rs12472886; rs13428032; rs10497491; rs2164330; rs13008833; rs13413095; rs1438036; rs1561317; rs17635875; rs1852497; rs13384920; rs13411527; rs6754385; rs12618606; rs6738831; rs9288008; rs2695726; rs13422276; rs13396065; rs10930817; rs13012431; rs7605609; rs13422706; rs1344917; rs934807; rs7596644; rs6724987; rs1852500; rs12693144; rs13411970; rs7570898; rs6433704; rs6739044; rs2009303; rs1898587; rs6433687; rs6727390; rs7592278; rs13395965; rs12994405; rs13002118; rs11899173; rs16865821; rs7609487; rs10186273; rs6758923; rs12620627; rs2365899; rs13034432; rs13419927; rs6750991; rs7584838; rs35625771; rs13427929; rs13006992; rs13427912; rs16865697; rs10165299; rs7598835; rs13427600; rs9808095; rs13422021; rs13429906; rs10930819; rs7420642; rs10169917; rs10168605; rs16865643; rs12474141; rs4893986; rs16865593; rs6734297; rs7595421; rs7424429; rs11884289; rs6721029; rs13394480; rs16865835; rs10930806; rs13007187; rs10178125; rs6724505; rs7598748; rs6758297; rs11695211; rs16865887; rs2365898; rs16865921; rs12478848; rs17330075; rs13008857; rs9283485; rs16865912; rs12477170; rs16865743; rs2695723; rs10165196; rs12151806; rs13014945; rs13391502; rs6716206; rs16865998; rs16865753; rs7558301; rs16865852; rs10192990; rs10181377; rs12611503; rs1438053; rs16865752; rs7577174; rs16865698; rs16865791; rs17400526; rs1975324; rs7574565; rs1534305; rs10181024; rs16866036; rs17400834; rs6747512; rs6433686; rs7577598; rs16865493; rs13010041; rs13410486; rs10183838; rs13021998; rs13021204; rs1918347; rs12105799; rs2695721; rs17330012; rs13392577; rs13007766; rs7569124; rs12988331; rs10200643; rs1595443; rs6737549; rs10202536; rs4508637; rs9288013; rs12465539; rs16865848; rs2695744; rs3770013; rs13004037; rs16866003; rs2365621; rs16865844; rs1898588; rs2695101; rs1975321; rs13393722; rs1986843; rs9679360; rs9646795; rs3754994; rs934569; rs4511758; rs6760949; rs4324348; rs10186678; rs10176232; rs7556748; rs6746962; rs12613904; rs12989020; rs2365618; rs16866031; rs2695720; rs13413635; rs10165192; rs16865933; rs13019660; rs3770043; rs7588304; rs2056715; rs7568082; rs12616288; rs9679242; rs3770014; rs16865642; rs4277559; rs16865772; rs7557136; rs13398395; rs12622125; rs9677101; rs13006098; rs10208589; rs4456736; rs13004202; rs6745398; rs6755382; rs7593744; rs6758473; rs11684363; rs2178018; rs1898589; rs10193299; rs10179500; rs13421432; rs13408518; rs13023939; rs13386827; rs13395151; rs10195518; rs10179821; rs1347730; rs16865748; rs13386657; rs1370660; rs6433700; rs6738098; rs12469884; rs16865706; rs7609350; rs7607094; rs2695747; rs16865850; rs12987515; rs6729216; rs10168715; rs17401951; rs12994913; rs10182150; rs2695752; rs13007759; rs1438055; rs11885059; rs13423503; rs6708449; rs7596360; rs10497477; rs16865527; rs10497489; rs4585066; rs1370659; rs1344924; rs10432481; rs11684953; rs10497481; rs12615564; rs16865651; rs10184562; rs11901841; rs10432482; rs3770036; rs1369518; rs2366354; rs13030321; rs11888049; rs16865771; rs1898590; rs941272; rs17329531; rs16865684; rs16865846; rs10165826; rs13014074; rs6747480; rs2695731; rs6761951; rs10168170; rs1946812; rs1866214; rs10930810; rs4893977; rs11694948; rs12612475; rs7423941; rs12990471; rs2695734; rs4893978; rs1438056; rs11682717; rs7570577; rs10176298; rs4893971; rs1547582; rs6731237; rs9653239; rs2695748; rs1527408; rs13421772; rs17636214; rs1344920; rs16865625; rs12467363; rs13384016; rs7557138; rs10211367; rs17329062; rs10469714; rs2695108; rs13018609; rs13408911; rs1949965; rs9679120; rs12475108; rs1527409; rs16865726; rs16865839; rs934567; rs13424417; rs7607529; rs1527406; rs10190199; rs3861373; rs1527290; rs10181136; rs10202419; rs10432483; rs11690583; rs1898586; rs2365622; rs13021356; rs10194612; rs12466205; rs2695745; rs2886422; rs998061; rs16865694; rs10930812; rs11683425; rs11896144; rs13413731; rs17401916; rs12615826; rs1918346; rs13399957; rs10195497; rs1405644; rs3770022; rs7578601; rs10171079; rs13406220; rs16823484; rs3214674; rs16865907; rs16865999; rs6433681; rs10803914; rs13411661; rs16865668; rs10166083; rs10203217; rs16865764; rs17687217; rs2950408; rs10164794; rs2695105; rs10187879; rs6735911; rs13385960; rs6714147; rs16865711; rs6714540; rs1405717; rs13403540; rs13395159; rs4893838; rs6712039; rs6735387; rs1438041; rs11894110; rs16866043; rs17401986; rs6709222; rs7562940; rs6743194; rs10173243; rs13012088; rs4893983; rs1561315; rs3770027; rs10202188; rs934568; rs10190154; rs10206282; rs10182386; rs16865670; rs2043547; rs2695096; rs6761540; rs1438058; rs13421135; rs10180071; rs10172247; rs17329811; rs11885795; rs13391629; rs16865533; rs6706739; rs9973525; rs2886423; rs16865951; rs10930811; rs1949966; rs764780; rs934805; rs7575717; rs16865647; rs13412181; rs13421415; rs7591504; rs10165089; rs9989817; rs11898798; rs13023495; rs6726253; rs1852498; rs6731843; rs7565183; rs3821011; rs16865869; rs16865868; rs10930822; rs1438059; rs10189110; rs12151805; rs16865940; rs16865591; rs1527297; rs7581861; rs11901771; rs1530036; rs10190066; rs7560737; rs2695750; rs714529; rs6433683; rs16865838; rs7592731; rs13396204; rs7563140; rs6704966; rs10930818; rs3770054; rs1344919; rs2695095; rs13397448; rs16865903; rs16865514; rs6731684; rs17401671; rs2365894; rs6726809; rs16865829; rs13423418; rs4143805; rs10178433; rs2695727; rs16865678; rs16865641; rs16865676; rs10167783; rs10168657; rs13425796; rs16865709; rs10192255; rs6711886; rs13396207; rs16865767; rs7588187; rs13395521; rs6713949; rs13409414; rs7592459; rs1438047; rs1527404; rs6709092; rs10176133; rs10930804; rs9989802; rs3770032; rs9677392; rs7565182; rs16865776; rs2365897; rs16865509; rs10930821; rs13400109; rs13400411; rs11899873; rs16865858; rs16865617; rs13414329; rs1358300; rs9288012; rs7585543; rs4377360; rs11902106; rs2020215; rs6717814; rs7573820; rs6433684; rs16865576; rs10166758; rs10211341; rs13394477; rs35397469; rs6756948; rs4893973; rs17687668; rs12469439; rs10186953; rs13387463; rs16865769; rs16865818; rs16865833; rs2060491; rs10177961; rs13028692; rs11674779; rs4893974; rs9677970; rs13386870; rs10169010; rs16865508; rs2365623; rs10930813; rs11890088; rs16865862; rs13002444; rs35987785; rs16865885; rs3952630; rs1344921; rs16865700; rs7581711; rs13392161; rs11682753; rs16866034; rs3821006; rs726985; rs16865689; rs10209050; rs3770046; rs7565179; rs3770029; rs16865701; rs6718100; rs9677090; rs934570; rs4474917; rs16865501; rs6723031; rs6730406; rs920092; rs6723063; rs920093; rs6722891; rs920094; rs1347440; rs920095; rs12468187; rs34839657; rs35253164; rs1946702; rs35210671; rs1982132; rs34365455; rs13005502; rs3056853; rs2695736; rs35071676; rs35669568; rs7421536; rs10167777; rs35607901; rs10201731; rs34374310; rs12994303; rs35897066; rs941366; rs35952531; rs34795277; rs35691085; rs7586771; rs10183014; rs28679800; rs34956941; rs34744300; rs34148524; rs13423344; rs34041168; rs6708473; rs35233809; rs34463789; rs10183536; rs34568807; rs35365213; rs34298599; rs3770031; rs35641196; rs13427473; rs41429950; rs35218489; rs35716038; rs35168006; rs35207489; rs35698274; rs34234621; rs34528505; rs3067363; rs2695100; rs5836630; rs10669353; rs41397549; rs35200915; rs12615720; rs13428260; rs1595442; rs35815103; rs11457930; rs35972715; rs35782989; rs35450676; rs33997655; rs35184228; rs11273279; rs34378430; rs35625068; rs13413922; rs35931940; rs12465589; rs34717744; rs34130310; rs12991811; rs13407054; rs956410; rs7567962; rs35810469; rs12998308; rs12992347; rs2886652; rs5836633; rs5836625; rs3813254; rs10174152; rs13409408; rs34459847; rs34543540; rs11421886; rs1438052; rs10654194; rs13011140; rs11457660; rs6433692; rs16865870; rs28380215; rs7600557; rs16865855; rs34233581; rs34509785; rs35068650; rs35319085; rs35244974; rs6741812; rs36180727; rs2366351; rs35894325; rs28700947; rs35793465; rs12990178; rs11352844; rs11304036; rs6147043; rs2695110; rs34434094; rs34839662; rs13409520; rs16865786; rs3056901; rs13013052; rs11895601; rs34245692; rs35699369; rs34622176; rs34326338; rs16866002; rs35267683; rs3056858; rs5836628; rs35020639; rs34909518; rs34605619; rs34338097; rs35391652; rs10195936; rs11290620; rs1852499; rs34327277; rs6758508; rs12989513; rs2695114; rs5836640; rs28496693; rs36051210; rs4302244; rs34025288; rs4110130; rs9677138; rs10167356; rs10622468; rs35391362; rs34677149; rs13408009; rs2695758; rs35268083; rs10558379; rs34921790; rs36186712; rs13399953; rs35319486; rs34242723; rs6710818; rs34632698; rs10167418; rs13383696; rs3905344; rs5836622; rs35615752; rs1123138; rs35635398; rs10654163; rs10527143; rs34093593; rs35892092; rs12989062; rs35775900; rs3835950; rs10187874; rs34928961; rs36003437; rs5836636; rs34403322; rs6756270; rs35443310; rs2695749; rs34356580; rs10686756; rs13018347; rs3835952; rs28498363; rs34698321; rs33980746; rs12999814; rs7575777; rs35723966; rs11400619; rs35537949; rs12151372; rs35063921; rs3073405; rs35277317; rs11460197; rs34661271; rs33952943; rs11297475; rs9679102; rs10209248; rs34358653; rs6739045; rs10193573; rs34678364; rs34644164; rs16823485; rs35134722; rs11365222; rs2573081; rs35105885; rs10176536; rs6433689; rs2695751; rs1020011; rs34334554; rs13409454; rs13426623; rs10546304; rs7569826; rs13024864; rs4417752; rs11357476; rs11423127; rs6753377; rs1438043; rs10697352; rs13426123; rs11374940; rs36043707; rs35875834; rs34479958; rs12328658; rs34144749; rs34283040; rs35610210; rs13002398; rs2695093; rs35805580; rs3841879; rs5836635; rs35486028; rs35969908; rs36121526; rs4893990; rs7584732; rs36197320; rs34088312; rs2695318; rs36130267; rs10190750; rs1866213; rs11304532; rs12466953; rs3056896; rs941273; rs13409258; rs34430258; rs36033403; rs11332498; rs34293348; rs34718493; rs34648335; rs35600620; rs35749062; rs13420280; rs34108864; rs35262842; rs13432633; rs35217344; rs7607438; rs13021169; rs13001148; rs10176527; rs34087687; rs28590730; rs35758079; rs13416761; rs35427161; rs13001447; rs10557532; rs4019842; rs12986929; rs3835949; rs16865485; rs36058776; rs11399942; rs36210065; rs6729893; rs5836632; rs35228328; rs6731331; rs13013706; rs941365; rs34385021; rs35391554; rs35885074; rs35323285; rs10168683; rs34952652; rs34444737; rs34330215; rs36118068; rs4464320; rs35219250; rs13382373; rs12992086; rs34973644; rs13018404; rs16865713; rs4893982; rs10211625; rs34035940; rs2950572; rs6758139; rs35812247; rs7421535; rs35011517; rs3067362; rs12995165; rs13430954; rs5836641; rs12999027; rs35046636; rs12612301; rs34596457; rs35254631; rs35906687; rs4297923; rs1975322; rs34035499; rs1527289; rs35862134; rs3770042; rs2091441; rs34406776; rs9677777; rs13007385; rs10556235; rs34486056; rs13029844; rs35102487; rs13023837; rs10692818; rs34464620; rs34330915; rs35517342; rs35848472; rs34582585; rs16865918; rs35288915; rs35902413; rs13389387; rs6433707; rs34369002; rs34417507; rs34790520; rs34510795; rs34612479; rs34602607; rs2365624; rs10209852; rs2695761; rs11457371; rs3056940; rs35549571; rs28791491; rs11892897; rs36013928; rs11887774; rs10176535; rs35290022; rs6725044; rs33984696; rs35420167; rs10172384; rs34505237; rs12997716; rs12994392; rs34366957; rs34210867; rs34772724; rs1852496; rs12618253; rs36180284; rs35305315; rs12992938; rs36003055; rs34392533; rs34682002; rs10685021; rs34595897; rs5836620; rs3830637; rs35655847; rs1438044; rs2573084; rs35231531; rs34945224; rs35156922; rs12472798; rs34934707; rs10669885; rs13009183; rs35939912; rs5836626; rs35688482; rs7571646; rs11310982; rs34365395; rs33967413; rs7421195; rs34327803; rs10572990; rs35642038; rs10175142; rs6433696; rs4893846; rs13007409; rs34717034; rs35462778; rs5836619; rs10432484; rs11333080; rs33971104; rs12993389; rs4487117; rs5836631; rs35217913; rs3037874; rs35797524; rs13031478; rs34142188; rs34917842; rs11685582; rs3037901; rs35338943; rs5836623; rs34767203; rs6712779; rs34682886; rs34206020; rs12472460; rs35337472; rs3073403; rs883171; rs13023528; rs10190560; rs3066395; rs35421971; rs13019139; rs35798690; rs13408844; rs11901207; rs34902120; rs34884047; rs34567061; rs1438042; rs10603345; rs13010993; rs34794477; rs35316377; rs35726367; rs13013319; rs35837681; rs35253854; rs5836638; rs5836629; rs13391481; rs6731280; rs34147365; rs3770021; rs34261053; rs28787871; rs35996255; rs13029944; rs13016598; rs2695722; rs35267698; rs28867487; rs13033904; rs36022334; rs11378638; rs34355087; rs34532538; rs12994400; rs34743754; rs12992244; rs13401710; rs10608828; rs34449576; rs13431317; rs13406131; rs35757742; rs35810822; rs36042877; rs1609094; rs2695739; rs2365891; rs34096798; rs959791; rs1467360; rs34758781; rs3770041; rs12998843; rs34556327; rs36035504; rs35120376; rs34413904; rs11898579; rs6708580; rs34448095; rs10178916; rs36005794; rs10187897; rs34650718; rs35691613; rs35343829; rs35952657; rs1438057; rs10178858; rs2717524; rs2118483; rs7602131; rs2695090; rs3056854; rs34059969; rs36021106; rs10185318; rs34216494; rs10211637; rs11680530; rs35104703; rs10690181; rs13017462; rs5025339; rs34171827; rs3770037; rs11333128; rs34330646; rs2695759; rs10185973; rs34484134; rs5015687; rs3031405; rs35765328; rs10684663; rs13031632; rs34503988; rs34692952; rs36088611; rs36161140; rs7605249; rs2695733; rs3770030; rs11333208; rs11457658; rs2196339; rs10700821; rs11409979; rs33971087; rs35212627; rs12476700; rs4464321; rs34302432; rs10194586; rs35611922; rs28408453; rs13007673; rs13415041; rs33957872; rs5836637; rs35064446; rs34364822; rs7571908; rs35531468; rs10613859; rs34995971; rs34148492; rs35924394; rs35678669; rs13405755; rs4487116; rs10614762; rs35194777; rs13028628; rs12473852; rs35134190; rs12990878; rs35887587; rs3948256; rs34381368; rs10182833; rs35525333; rs2573086; rs3067378; rs34721738; rs10534597; rs2365890; rs13405457; rs10183345; rs13394193; rs941275; rs4536679; rs35362919; rs10176643; rs13026166; rs13006712; rs13385419; rs12233175; rs13001444; rs2717525; rs33997176; rs11363547; rs28529577; rs12992252; rs10427227; rs35631376; rs11367453; rs35097265; rs12612164; rs34842463; rs6414096; rs10187884; rs35795321; rs35302466; rs13416636; rs13024861; rs35990574; rs2695754; rs7605985; rs10185145; rs10182353; rs3056942; rs13018132; rs34938001; rs35041048; rs10539109; rs13024254; rs11329681; rs34952215; rs2695106; rs13418653; rs13421345; rs5836627; rs34513757; rs35586165; rs3056937; rs13020684; rs34383497; rs6738358; rs7571919; rs5015686; rs10556225; rs12988281; rs13388218; rs34385779; rs34054341; rs35335000; rs10930808; rs11291265; rs28707296; rs2366350; rs34624647; rs12992249; rs2886425; rs34878348; rs35248478; rs13001522; rs34660521; rs34081471; rs4341976; rs35975029; rs35773107; rs13418469; rs34682348; rs35764219; rs10182017; rs10186697; rs6731030; rs35927962; rs34281475; rs34018298; rs35782761; rs12987271; rs7558482; rs1918345; rs34823486; rs4110136; rs11284596; rs34568974; rs34915755; rs13405581; rs34164632; rs35225617; rs3770017; rs3037903; rs13427846; rs34702209; rs9646739; rs4538242; rs35978357; rs35481440; rs1344918; rs34948302; rs10564225; rs35303018; rs10534752; rs13022267; rs3770020; rs35929026; rs41394144; rs13002209; rs13027484; rs2118481; rs10563932; rs35404128; rs34110195; rs6758644; rs34323062; rs2196340; rs35748044; rs41440047; rs34246439; rs13427452; rs34792403; rs12994590; rs35830357; rs13396582; rs10579905; rs13012298; rs13385424; rs35517887; rs11450947; rs35522885; rs1358301; rs6713660; rs35696051; rs10629866; rs35973852; rs35591668; rs28771225; rs12472515; rs34764794; rs34507449; rs13383409; rs34473216; rs34249286; rs10803913; rs4338993; rs35420534; rs1880915; rs2695113; rs35520979; rs34473720; rs6723691; rs35578521; rs35733927; rs13023390; rs13023494; rs4893836; rs35983142; rs5836639; rs2695107; rs35749582; rs34149684; rs13019623; rs1438050; rs36046079; rs28621588; rs13385949; rs2083156; rs10541503; rs6716288; rs34335666; rs3066392; rs35403482; rs34431240; rs35439189; rs35316735; rs3056898; rs5836624; rs28889598; rs7421650; rs10187888; rs11343355; rs28536016; rs6147041; rs7420029; rs2037758; rs10930807; rs7565114; rs34185358; rs10192928; rs35873373; rs3031403; rs13020834; rs5836618; rs10211632; rs16865909; rs35728831; rs13025164; rs36032173; rs6147042; rs36149489; rs35130337; rs34164917; rs34684690; rs35836349; rs34215270; rs12992250; rs34628381; rs7573440; rs13017254; rs41357848; rs10178473; rs2365892; rs10693827; rs9646738; rs35538692; rs35385829; rs33947390; rs36106717; rs34752624; rs7589980; rs34839058; rs35709030; rs34699522; rs6747137; rs13393975; rs34571198; rs36062129; rs2196694; rs34747248; rs6711034; rs12987107; rs35510151; rs34363929; rs10558072; rs5836634; rs34047994; rs1609095; rs13013724; rs34293884; rs13419130; rs2695755; rs934810; rs34044811; rs2196341; rs36094310; rs3770049; rs3056903; rs12993458; rs7594362; rs13002711; rs13002713; rs13027895; rs11694013; rs34941794; rs10174337; rs10209616; rs1047884; rs11676719; rs12620285; rs12990917; rs13023049; rs13032997; rs13033229; rs13397357; rs13419755; rs13421475; rs1369517; rs1405643; rs1435572; rs1527286; rs1527287; rs1534304; rs16865452; rs16865453; rs16865475; rs16865476; rs16865993; rs16866025; rs16866053; rs16866058; rs17330381; rs1836672; rs1982130; rs2117739; rs2293471; rs2293472; rs2293473; rs3829751; rs3829752; rs4436997; rs4893970; rs6710329; rs6720272; rs6726222; rs6740828; rs6752913; rs6754705; rs6756918; rs7574975

# Macromolecular_Interacting_Partner_12_General_References:
Not Available

# Macromolecular_Interacting_Partner_12_References:
Not Available

End of HMDB00045

Beginning of HMDB00048
# Accession_No:
HMDB00048

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-05-23 11:06:25

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Melibiose

# Description:
A disaccharide consisting of one galactose and one glucose moiety in an alpha (1-6) glycosidic linkage.  This sugar is produced and metabolized only by enteric and lactic acid bacteria and other microbes.  It is not an endogenous metabolite.  Antibodies to melibiose will appear in individuals affected by Chagas' disease (Trypanosoma cruzi infection).  Melibiose is not metabolized by humans.

# Synonyms:
6-(D-galactosido)-D-glucose; 6-(a-D-galactosido)-D-glucose; 6-O-Hexopyranosylhexose; 6-O-a-D-galactopyranosyl-D-Glucose; 6-O-alpha-D-galactopyranosyl-D-Glucose; D-(+)-Melibiose; D-Melibiose; Melibiose; Mellibiose; alpha-D-Melibiose; alpha-Melibiose; 6-(D-galactosido)-delta-glucose; 6-(a-delta-galactosido)-delta-glucose; 6-O-alpha-delta-galactopyranosyl-delta-Glucose; delta-(+)-Melibiose; delta-Melibiose; alpha-delta-Melibiose

# Chemical_IUPAC_Name:
2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hexanal

# Chemical_Formula:
C12H22O11

# Chemical_Structure:
tbl_chemical:::HMDB00048_ZOOM.png:::11928315440527966

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00048_THUMB.png:::119283154188120198

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Sugars; Disaccharides

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiacetal; acetal; primary alcohol; secondary alcohol; 1,2-diol; heterocyclic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
342.11621

# Molecular_Weight_Avg:
342.29651

# Smiles_String_isomeric:
OC[C@H]1O[C@H](OC[C@H]2OC(O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@H]1O

# Smiles_String_canonical:
OCC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1O

# KEGG_Compound_ID:
C05402

# BioCyc_ID:
MELIBIOSE

# PubChem_CID:
440658

# PubChem_SID:
7769; 10298632

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Not Available

# METLIN_ID:
3478

# Ref_ID:
1706399; 7795409; 7576587; 7524207; 10585631; 8919354; 528053; 7842233; 10799474; 809216; 8521444

# ChEBI_ID:
28053

# CAS_Registry_Number:
585-99-9

# InChI:
InChI=1/C12H22O11/c13-1-3-5(14)8(17)10(19)12(23-3)21-2-4-6(15)7(16)9(18)11(20)22-4/h3-20H,1-2H2/t3-,4-,5+,6-,7+,8+,9-,10-,11u,12+/m1/s1

# Synthesis_Reference:
Rapid oligosaccharide synthesis on a fluorous support.     Goto, Kohtaro; Miura, Tsuyoshi; Hosaka, Daisuke; Matsumoto, Hiroharu; Mizuno, Mamoru; Ishida, Hide-ki; Inazu, Toshiyuki.    Labolatry of Glycoorganic Chemistry,  The Noguchi Institute,  Itabashi-k

# Melting_Point:
84 oC

# Melting_Point_predicted:
141.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1000.0 mg/mL [MERCK INDEX (1996)]

# H2O_Solubility_Predicted:
511.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-3.00 [Predicted by ALOGPS]; -4.1 [Predicted by PubChem via XLOGP]; -5.30 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C05402.mol:::1132723803390481914

# SDF_File_[Text]:
tbl_chemical:::HMDB00048.sdf:::119283153632273721

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00048.pdb:::11928315401971620

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041026_P00_02_HW_1DP_presat.png:::114624884159485807

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041026_P00_02_HW_1DP_presat.zip:::11462488416009837

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041026_P00_02_HW_1DP_Assigned.png:::115635569859985468

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::041026_P00_02_HW_1DC_15.jpg:::114168459743453391

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041026_P00_02_HW_1DC_15.zip:::114168459740464338

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041026_P00_02_HW_1DC_15_Assigned.jpg:::114488011236360058

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041026_P00_02_HW_2DHSQC_114.jpg:::114495744616348812

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041026_P00_02_HW_2DHSQC_114.zip:::114495744618634631

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041026_P00_02_HW_2DHSQC_114_Assigned.jpg:::115929340085761096

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Melibiose.gif:::11532492327457031

# pred_hnmr_peaklist:
Not Available

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Melibiose_C.gif:::115324923277017534

# pred_cnmr_peaklist:
Not Available

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00048.png:::1165435230637597580; Medium Energy:tbl_ms:::HMDB00048.png:::116543466515143814; High Energy:tbl_ms:::HMDB00048.png:::1165434857212326714

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Extracellular; Cytoplasm (Predicted from LogP)

# Tissue_Location:
Spleen; Tissues Containing Microbial Flora

# deuterated:
No

# Biofluid_Location:
Urine

# Concentration_[Normal]:
Urine	< 0.1	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	10585631


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Chagas' Disease; Paediatric short-bowel syndrome

# Pathway_Names:
Galactose metabolism;Starch and sucrose metabolism;Glycerolipid metabolism;Glycosphingolipid metabolism

# Pathway_Images:
;;;

# KEGG_Images:
map00052;map00500;map00561;map00600

# Pathway_Graphs:
;;;

# Pathway_SBMLs:
;;;

# Metabolic_Enzyme_1_ID:
5997

# Metabolic_Enzyme_1_Name:
Alpha-galactosidase A precursor

# Metabolic_Enzyme_1_Synonyms:
Melibiase; Alpha-D- galactoside galactohydrolase; Alpha-D-galactosidase A; Agalsidase alfa

# Metabolic_Enzyme_1_Gene_Name:
GLA

# Metabolic_Enzyme_1_Protein_Sequence:
>Alphagalactosidase A precursor
MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEP
DSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQL
ANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENL
ADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIK
SILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDL
RHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIG
GPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENT
MQMSLKDLL

# Metabolic_Enzyme_1_Number_of_Residues:
429

# Metabolic_Enzyme_1_Molecular_Weight:
48767

# Metabolic_Enzyme_1_Theoretical_pI:
5.27

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Hydrolysis of terminal, non-reducing alpha-D- galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase

# Metabolic_Enzyme_1_Pathway:
map00052  Galactose metabolism;
 map00561  Glycerolipid metabolism;
 map00600  Glycosphingolipid metabolism;
 map00603  Globoside metabolism

# Metabolic_Enzyme_1_Reaction:
Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF02065:Melibiase

# Metabolic_Enzyme_1_Signals:
1-31

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.2.1.22

# Metabolic_Enzyme_1_GenBank_ID_Protein:
757912

# Metabolic_Enzyme_1_SwissProt_ID:
AGAL_HUMAN (P06280)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
GLA

# Metabolic_Enzyme_1_Geneatlas_id:
GLA

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4296

# Metabolic_Enzyme_1_PDB_ID:
1R47

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_1_Gene_Sequence:
>1290 bp
ATGCAGCTGAGGAACCCAGAACTACATCTGGGCTGCGCGCTTGCGCTTCGCTTCCTGGCC
CTCGTTTCCTGGGACATCCCTGGGGCTAGAGCACTGGACAATGGATTGGCAAGGACGCCT
ACCATGGGCTGGCTGCACTGGGAGCGCTTCATGTGCAACCTTGACTGCCAGGAAGAGCCA
GATTCCTGCATCAGTGAGAAGCTCTTCATGGAGATGGCAGAGCTCATGGTCTCAGAAGGC
TGGAAGGATGCAGGTTATGAGTACCTCTGCATTGATGACTGTTGGATGGCTCCCCAAAGA
GATTCAGAAGGCAGACTTCAGGCAGACCCTCAGCGCTTTCCTCATGGGATTCGCCAGCTA
GCTAATTATGTTCACAGCAAAGGACTGAAGCTAGGGATTTATGCAGATGTTGGAAATAAA
ACCTGCGCAGGCTTCCCTGGGAGTTTTGGATACTACGACATTGATGCCCAGACCTTTGCT
GACTGGGGAGTAGATCTGCTAAAATTTGATGGTTGTTACTGTGACAGTTTGGAAAATTTG
GCAGATGGTTATAAGCACATGTCCTTGGCCCTGAATAGGACTGGCAGAAGCATTGTGTAC
TCCTGTGAGTGGCCTCTTTATATGTGGCCCTTTCAAAAGCCCAATTATACAGAAATCCGA
CAGTACTGCAATCACTGGCGAAATTTTGCTGACATTGATGATTCCTGGAAAAGTATAAAG
AGTATCTTGGACTGGACATCTTTTAACCAGGAGAGAATTGTTGATGTTGCTGGACCAGGG
GGTTGGAATGACCCAGATATGTTAGTGATTGGCAACTTTGGCCTCAGCTGGAATCAGCAA
GTAACTCAGATGGCCCTCTGGGCTATCATGGCTGCTCCTTTATTCATGTCTAATGACCTC
CGACACATCAGCCCTCAAGCCAAAGCTCTCCTTCAGGATAAGGACGTAATTGCCATCAAT
CAGGACCCCTTGGGCAAGCAAGGGTACCAGCTTAGACAGGGAGACAACTTTGAAGTGTGG
GAACGACCTCTCTCAGGCTTAGCCTGGGCTGTAGCTATGATAAACCGGCAGGAGATTGGT
GGACCTCGCTCTTATACCATCGCAGTTGCTTCCCTGGGTAAAGGAGTGGCCTGTAATCCT
GCCTGCTTCATCACACAGCTCCTCCCTGTGAAAAGGAAGCTAGGGTTCTATGAATGGACT
TCAAGGTTAAGAAGTCACATAAATCCCACAGGCACTGTTTTGCTTCAGCTAGAAAATACA
ATGCAGATGTCATTAAAAGACTTACTTTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X05790

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_1_Locus:
Xq22

# Metabolic_Enzyme_1_SNPs:
rs2071228; rs2071397; rs5991933; rs3027588; rs2071396; rs11795552; rs1023431; rs2515901; rs5991931; rs12392549; rs28935493; rs28935495; rs28935488; rs28935486; rs28935492; rs28935489; rs28935485; rs28935487; rs28935490; rs28935494; rs28935491; rs28452934; rs2473815; rs5903184; rs34068797; rs3027591; rs12841946; rs41311559; rs1023432; rs36101431; rs34320747; rs34454314; rs11448515; rs3027589; rs36058885; rs35370748; rs35549513; rs35394408; rs34194580; rs1023433; rs41307413; rs35691745; rs3027590; rs3027592; rs34242315; rs12394005; rs34891827; rs35186437; rs35512527; rs35765403; rs34004522; rs5991932; rs7051126; rs35785460; rs10673283; rs34192850; rs35019768; rs1050058; rs2071226; rs2071227; rs2143597; rs2361007; rs3027575; rs3027576; rs3027577; rs3027578; rs3027579; rs3027580; rs3027581; rs3027582; rs3027583; rs3027584; rs3027586; rs3027593; rs3027594; rs3027595; rs3027596; rs3027597; rs3027598; rs3027599; rs3027600; rs5951308; rs6621053; rs6621054

# Metabolic_Enzyme_1_General_References:
3036505; 2542896; 7626884; 3014515; 2892762; 2836863; 7503918; 7911050; 2152885; 1846223; 2171331; 2539398; 1315715; 7504405; 8395937; 8069316; 7531540; 7575533; 7759078; 7599642; 7596372; 8875188; 8834244; 8931708; 8807334; 8863162; 9105656; 9100224; 9452068; 9452090; 9452111; 10208848; 10090526; 10666480; 11076046; 10916280; 11295840; 11668641

# Metabolic_Enzyme_1_References:
11526023; 1337134; 15582614; 1651679

# Macromolecular_Interacting_Partner_1_ID:
7948

# Macromolecular_Interacting_Partner_1_Name:
Galectin-4

# Macromolecular_Interacting_Partner_1_Synonyms:
Lactose-binding lectin 4; L-36 lactose-binding protein; L36LBP; Antigen NY-CO-27

# Macromolecular_Interacting_Partner_1_Gene_Name:
LGALS4

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Galectin4
MAYVPAPGYQPTYNPTLPYYQPIPGGLNVGMSVYIQGVASEHMKRFFVNFVVGQDPGSDV
AFHFNPRFDGWDKVVFNTLQGGKWGSEERKRSMPFKKGAAFELVFIVLAEHYKVVVNGNP
FYEYGHRLPLQMVTHLQVDGDLQLQSINFIGGQPLRPQGPPMMPPYPGPGHCHQQLNSLP
TMEGPPTFNPPVPYFGRLQGGLTARRTIIIKGYVPPTGKSFAINFKVGSSGDIALHINPR
MGNGTVVRNSLLNGSWGSEEKKITHNPFGPGQFFDLSIRCGLDRFKVYANGQHLFDFAHR
LSAFQRVDTLEIQGDVTLSYVQI

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
323

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
35942

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
9.48

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00337:Gal-bind_lectin

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
2385454

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
LEG4_HUMAN (P56470)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
LGALS4

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
LGALS4

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6565

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>972 bp
ATGGCCTATGTCCCCGCACCGGGCTACCAGCCCACCTACAACCCGACGCTGCCTTACTAC
CAGCCCATCCCGGGCGGGCTCAACGTGGGAATGTCTGTTTACATCCAAGGAGTGGCCAGC
GAGCACATGAAGCGGTTCTTCGTGAACTTTGTGGTTGGGCAGGATCCGGGCTCAGACGTC
GCCTTCCACTTCAATCCGCGGTTTGACGGCTGGGACAAGGTGGTCTTCAACACGTTGCAG
GGCGGGAAGTGGGGCAGCGAGGAGAGGAAGAGGAGCATGCCCTTCAAAAAGGGTGCCGCC
TTTGAGCTGGTCTTCATAGTCCTGGCTGAGCACTACAAGGTGGTGGTAAATGGAAATCCC
TTCTATGAGTACGGGCACCGGCTTCCCCTACAGATGGTCACCCACCTGCAAGTGGATGGG
GATCTGCAACTTCAATCAATCAACTTCATCGGAGGCCAGCCCCTCCGGCCCCAGGGACCC
CCGATGATGCCACCTTACCCTGGTCCCGGACATTGCCATCAACAGCTGAACAGCCTGCCC
ACCATGGAAGGACCCCCAACCTTCAACCCGCCTGTGCCATATTTCGGGAGGCTGCAAGGA
GGGCTCACAGCTCGAAGAACCATCATCATCAAGGGCTATGTGCCTCCCACAGGCAAGAGC
TTTGCTATCAACTTCAAGGTGGGCTCCTCAGGGGACATAGCTCTGCACATTAATCCCCGC
ATGGGCAACGGTACCGTGGTCCGGAACAGCCTTCTGAATGGCTCGTGGGGATCCGAGGAG
AAGAAGATCACCCACAACCCATTTGGTCCCGGACAGTTCTTTGATCTGTCCATTCGCTGT
GGCTTGGATCGCTTCAAGGTTTACGCCAATGGCCAGCACCTCTTTGACTTTGCCCATCGC
CTCTCGGCCTTCCAGAGGGTGGACACATTGGAAATCCAGGGTGATGTCACCTTGTCCTAT
GTCCAGATCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AB006781

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_1_Locus:
19q13.2

# Macromolecular_Interacting_Partner_1_SNPs:
rs8106404; rs1035524; rs8113319; rs7250734; rs1035525; rs4802887; rs4802888; rs4375781; rs12463099; rs12610990; rs10775532; rs12460812; rs8111357; rs7507803; rs12977453; rs2052569; rs4802886; rs4575642; rs12972114; rs10404489; rs10417292; rs12461466; rs884299; rs10403583; rs35631131; rs10441; rs4575640; rs34677297; rs11670263; rs3993040; rs10423776; rs11881973; rs10084119; rs2403781; rs3745866; rs2403782; rs10414466; rs35490470; rs2403780; rs5828018; rs34382537; rs11319100; rs4575641; rs34812797; rs34820201; rs35520148; rs10531431; rs3076964; rs4254434; rs3898955; rs7507286; rs28405800; rs4802890; rs35905844; rs12460580; rs10423065; rs10424620; rs10426289; rs1064972; rs1078733; rs1078734; rs10967; rs11669239; rs12980315; rs2017784; rs2075587; rs2075588; rs2229259; rs2229260; rs2287952; rs2287953; rs2287954; rs2303172; rs7247185; rs889327; rs9749397

# Macromolecular_Interacting_Partner_1_General_References:
9310382; 9162064

# Macromolecular_Interacting_Partner_1_References:
2944111; 6092916

End of HMDB00048

Beginning of HMDB00050
# Accession_No:
HMDB00050

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-16 13:04:10

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Adenosine

# Description:
A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. For instance, adenosine plays an important role in energy transfer - as adenosine triphosphate (ATP) and adenosine diphosphate (ADP).  It also plays a role in signal transduction as cyclic adenosine monophosphate, cAMP. Adenosine itself is both a neurotransmitter and potent vasodilator. When administered intravenously, adenosine causes transient heart block in the AV node. Because of the effects of adenosine on AV node-dependent supraventricular tachycardia, adenosine is considered a class V antiarrhythmic agent.

# Synonyms:
1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose; 6-Amino-9beta-D-ribofuranosyl-9H-purine; 9-beta-D-Arabinofuranosyladenine; 9-beta-D-Ribofuranosidoadenine; 9-beta-D-Ribofuranosyl-9H-purin-6-amine; 9-beta-d-Ribofuranosyladenine; 9beta-D-Ribofuranosyladenine; 9beta-D-ribofuranosyl-9H-Purin-6-amine; Adenine nucleoside; Adenine riboside; Adenocard; Adenocor; Adenoscan; Adenosin; Boniton; Myocol; Nucleocardyl; Sandesin; adenine-9beta-D-Ribofuranoside; b-D-Adenosine; beta-Adenosine; 1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-delta-Ribofuranose; 6-Amino-9beta-delta-ribofuranosyl-9H-purine; 9-beta-delta-Arabinofuranosyladenine; 9-beta-delta-Ribofuranosidoadenine; 9-beta-delta-Ribofuranosyl-9H-purin-6-amine; 9-beta-delta-Ribofuranosyladenine; 9beta-delta-Ribofuranosyladenine; 9beta-delta-ribofuranosyl-9H-Purin-6-amine; adenine-9beta-delta-Ribofuranoside; beta-delta-Adenosine; beta-D-Adenosine

# Chemical_IUPAC_Name:
2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

# Chemical_Formula:
C10H13N5O4

# Chemical_Structure:
tbl_chemical:::HMDB00050_ZOOM.png:::119283155504229090

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00050_THUMB.png:::119283155300386636

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; primary alcohol; secondary alcohol; 1,2-diol; primary amine; primary aromatic amine; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of Methionine metabolism; Component of Purine metabolism; Component of Selenoamino acid metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
267.09674

# Molecular_Weight_Avg:
267.24130

# Smiles_String_isomeric:
NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O

# Smiles_String_canonical:
NC1=NC=NC2=C1N=CN2C3OC(CO)C(O)C3O

# KEGG_Compound_ID:
C00212

# BioCyc_ID:
ADENOSINE

# PubChem_CID:
60961

# PubChem_SID:
828107; 197179; 597013; 825728; 11371396; 3512; 828519; 836875; 823399; 829493; 8027269; 837192; 821994; 11121293; 835338; 584490; 823450; 8023217; 11532674; 3136392; 7847113; 11489073; 584484; 585862; 12090919; 855932; 586357; 11120805; 7853711; 830178; 829606; 7978645; 207362; 11537606; 855078; 11490104; 825158; 833907; 830391; 10318629; 8143428; 11120317; 8187141; 823447; 8024149; 833174; 10322211; 826920; 11484930; 11532406; 819854; 836140; 11110168; 7885717

# OMIM_ID:
102800; 603005

# Metagene_ID:
ADENYLOSUCCINASE DEFICIENCY: 362

# BiGG_ID:
34273

# Wikipedia_ID:
Adenosine

# METLIN_ID:
86

# Ref_ID:
16178799; 15882454; 15116424; 16181820; 16177794; 16181825; 7686877; 15028034; 9869364; 6656991; 16177183; 12927681; 15455468

# ChEBI_ID:
16335

# CAS_Registry_Number:
58-61-7

# InChI:
InChI=1/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1

# Synthesis_Reference:
Ribonucleoside 2',3'-cyclic orthoformates.     Jarman, M.; Reese, C. B.    Univ. Chem. Lab.,  Cambridge,  UK.    Chemistry & Industry (London, United Kingdom)  (1964),   (34),  1493-4.

# Melting_Point:
235.5 oC

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
7 mg/mL [Adenocard product monograph]; 37 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
8.23 mg/mL [MEYLAN,WM et al. (1996)]; 14.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-1.05 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-1.20 [Predicted by ALOGPS]; -1.6 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Adenosine.htm:::1132562193449225054

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Adenosine.mol:::1132723803578811236

# SDF_File_[Text]:
tbl_chemical:::HMDB00050.sdf:::119283154839856646

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00050.pdb:::119283155127237773

# PDB_ID:
1BX4

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1BX4.txt:::1132720900171985498

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041007_P00_01_HW_1DP_PRESAT_expanded_2.gif:::114168246185697527

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041007_P00_01_HW_1DP_presat.zip:::1177710570027581246

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041007_P00_01_HW_1DP_Assigned.png:::117821566747616295

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041007_P00_01_HW_1DP_presat.png:::114850660506710030

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041007_P00_01_HW_1DP_presat.zip:::11485064510489875

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
tbl_cnmr:::041007_P00_01_HW_1DC_85.jpg:::114168476639054407

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041007_P00_01_HW_1DC_85.zip:::114168476635519197

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041007_P00_01_HW_1DC_85_Assigned.jpg:::115895131029442845

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041007_P00_01_HW_2DHSQC_43.jpg:::114617547584867838

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041007_P00_01_HW_2DHSQC_43.zip:::114617547585952726

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041007_P00_01_HW_2DHSQC_43_Assigned.jpg:::115895136188469363

# Predicted_H_NMR_Spectrum:
tbl_chemical:::adenosine.gif:::1132732102593132630

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00050_peaks.txt:::1156309510107736284

# Predicted_C_NMR_Spectrum:
tbl_chemical:::adenosine_C.gif:::1132737667071532436

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00050_peaks.txt:::115631070167940569

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00050L.png:::117555261872171441; Medium Energy:tbl_ms:::HMDB00050M.png:::117555267005464975; High Energy:tbl_ms:::HMDB00050H.png:::117555270873196920

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000061.png:::116899930860982513

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000061.txt:::116899930860929782

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000061.png:::116890825214023014

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000061.txt:::116890825242192968

# Cellular_Location:
Cytoplasm (Predicted from LogP); Extracellular; lysosome; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Cellular Cytoplasm; Urine

# Concentration_[Normal]:
Urine	4.7+/-7.0	umol/mmol_creatinine	Adult:>18_yrs_old	N/A	Normal	12927681
Urine	17.5+/-14.6	umol/mmol_creatinine	Children:1-13_yrs_old	N/A	Normal	12927681
Urine	0.50 (0.09-0.92)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	15116424
Blood	0.2 (0.1-0.3)	umol/L	Adult:>18_yrs_old	Both	Normal	6656991
Blood	0.025(0-0.050)	umol/L	Adult:>18_yrs_old	Both	Normal	17172976
Blood	0.31 +/- 0.29	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	0.01 +/- 0.002	umol/L	Adult:>18_yrs_old	N/A	Normal	15028034
Cerebrospinal_Fluid(CSF)	0 - 0.1	uM	Adult:>18_yrs_old	Both	Normal	6656991
Cellular_Cytoplasm	1.20 (0.90-1.50)	umol/L	Adult:>18_yrs_old	Both	Normal	15882454


# Concentration_[Abnormal]:
Urine	1.33	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Adenosine Deaminase (ADA) Deficiency	9869364
Blood	0.114 (0-0.228)	umol/L	Adult:>18_yrs_old	Both	Patients with septic shock	17172976


# Associated_Disorders:
Adenosine Deaminase (ADA) Deficiency; Asthma; Cachexia; Hyperhomocysteinemia; Immunodeficiency; Neurally Mediated Syncope; Patients with septic shock

# Pathway_Names:
Purine metabolism;Nicotinate and nicotinamide metabolism;Methionine metabolism

# Pathway_Images:
Purine_Synthesis.jpg;Nicotinamide_synthesis_(NADH).jpg;Methionine_Metabolism.jpg

# KEGG_Images:
map00230;map00760;map00271

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;Nicotinamide_synthesis_(NADH)_Graph.jpg;Methionine_Metabolism_Graph.jpg

# Pathway_SBMLs:
Purine_Synthesis.xml;Nicotinamide_synthesis_(NADH).xml;Methionine_Metabolism.xml

# Metabolic_Enzyme_1_ID:
5237

# Metabolic_Enzyme_1_Name:
Cytosolic purine 5'-nucleotidase

# Metabolic_Enzyme_1_Synonyms:
5'-nucleotidase cytosolic II

# Metabolic_Enzyme_1_Gene_Name:
NT5C2

# Metabolic_Enzyme_1_Protein_Sequence:
>Cytosolic purine 5'nucleotidase
MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVY
KSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLV
CAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTS
CETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMK
EVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGT
VLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKS
KKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQ
RRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAA
HVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLA
PQEITHCHDEDDDEEEEEEEE

# Metabolic_Enzyme_1_Number_of_Residues:
561

# Metabolic_Enzyme_1_Molecular_Weight:
64970

# Metabolic_Enzyme_1_Theoretical_pI:
6.05

# Metabolic_Enzyme_1_GO_Classification:
Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides

# Metabolic_Enzyme_1_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_1_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF05761:5_nucleotid

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
633071

# Metabolic_Enzyme_1_SwissProt_ID:
5NTC_HUMAN (P49902)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
NT5C2

# Metabolic_Enzyme_1_Geneatlas_id:
NT5C2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:8022

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1686 bp
ATGTCGACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGAT
AAGCATGCCCTGAAAAAGTATCGTCGAGAAGCCTATCATCGGGTGTTTGTGAACCGAAGT
TTAGCAATGGAAAAGATAAAGTGTTTTGGTTTTGATATGGATTATACCCTTGCTGTGTAC
AAGTCCCCAGAGTATGAGTCCCTTGGTTTTGAGCTTACTGTGGAGAGATTAGTTTCTATT
GGCTATCCCCAGGAGTTGCTCAGCTTTGCTTATGATTCTACATTCCCTACCAGGGGACTT
GTCTTTGACACACTGTATGGAAATCTTTTGAAAGTCGATGCCTATGGAAACCTCTTGGTC
TGTGCACATGGATTTAACTTTATAAGGGGACCAGAAACTAGAGAACAGTATCCAAATAAA
TTTATCCAGCGAGATGATACTGAAAGATTTTACATTCTGAACACACTATTCAACCTACCA
GAGACCTACCTGTTGGCCTGCCTAGTAGATTTTTTTACTAATTGTCCCAGATATACCAGT
TGTGAAACAGGATTTAAAGATGGGGACCTCTTCATGTCCTACCGGAGTATGTTCCAGGAT
GTAAGAGATGCTGTTGACTGGGTTCATTACAAGGGCTCCCTTAAGGAAAAGACAGTTGAA
AATCTTGAGAAGTATGTAGTCAAAGATGGAAAACTGCCTTTGCTTCTGAGCCGGATGAAG
GAAGTAGGGAAAGTATTTCTTGCTACCAACAGTGACTATAAATATACAGATAAAATTATG
ACTTACCTGTTTGACTTCCCACATGGCCCCAAGCCTGGGAGCTCCCATCGACCATGGCAG
TCCTACTTTGACTTGATCTTGGTGGATGCACGGAAACCACTCTTTTTTGGAGAAGGCACA
GTACTGCGTCAGGTGGATACTAAAACTGGCAAGCTGAAAATTGGTACCTACACAGGGCCC
CTACAGCATGGTATCGTCTACTCAGGAGGTTCTTCTGATACGATCTGTGACCTGTTGGGA
GCCAAGGGAAAAGACATTTTGTATATTGGAGATCACATTTTTGGGGACATTTTAAAATCA
AAGAAACGGCAAGGGTGGCGAACTTTTTTGGTGATTCCTGAACTCGCACAGGAGCTACAT
GTCTGGACTGACAAGAGTTCACTTTTCGAAGAACTTCAGAGCTTGGATATTTTCTTGGCT
GAACTCTACAAGCATCTTGACAGCAGTAGCAATGAGCGTCCAGACATCAGTTCCATCCAG
AGACGTATTAAGAAAGTAACTCATGACATGGACATGTGCTATGGGATGATGGGAAGCCTG
TTTCGCAGTGGCTCCCGGCAGACCCTTTTTGCCAGTCAAGTGATGCGTTATGCTGACCTC
TATGCAGCATCTTTCATCAACCTGCTGTATTACCCTTTCAGCTACCTCTTCAGGGCTGCC
CATGTCTTGATGCCTCATGAATCAACGGTGGAGCACACACACGTAGATATCAATGAGATG
GAGTCTCCTCTTGCCACCCGGAACCGCACATCAGTGGATTTCAAAGACACTGACTACAAG
CGGCACCAGCTGACACGGTCAATTAGTGAGATTAAACCTCCCAACCTCTTCCCACTGGCC
CCCCAGGAAATTACACACTGCCATGACGAAGATGATGATGAAGAGGAGGAGGAGGAGGAA
GAATAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
D38524

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_1_Locus:
10q24.32-q24.33

# Metabolic_Enzyme_1_SNPs:
rs12262171; rs3740387; rs12253627; rs10786736; rs8139; rs7917650; rs10786741; rs7920251; rs10430665; rs7916854; rs12573199; rs11191598; rs1163238; rs12573200; rs10883843; rs7092407; rs12573221; rs4917997; rs11191593; rs11191596; rs10786744; rs1163236; rs10883842; rs10786742; rs10786743; rs7075552; rs7077097; rs2863728; rs3758543; rs7077291; rs10748838; rs3087681; rs12240508; rs732998; rs10883830; rs7899084; rs2274340; rs2182348; rs2066322; rs7908960; rs7912517; rs7067970; rs3740386; rs7896547; rs11191554; rs1163249; rs2281877; rs2863727; rs3781281; rs2274341; rs2148198; rs7897663; rs3781282; rs10883832; rs1926029; rs1935323; rs1926030; rs746293; rs6584539; rs2066323; rs9919482; rs3740385; rs12773916; rs12414232; rs10786737; rs12413046; rs12412038; rs2274339; rs11598702; rs1541213; rs11191580; rs11191553; rs10509765; rs10509766; rs3977751; rs12220375; rs4917996; rs7896433; rs6584540; rs1926037; rs3736922; rs11191577; rs2148197; rs11191561; rs7080935; rs11191555; rs10883833; rs12219304; rs1926036; rs7913920; rs10883834; rs11191558; rs11191582; rs11191589; rs10883831; rs12220743; rs10786738; rs11191560; rs10748837; rs11191578; rs3781280; rs7896519; rs12217501; rs11191573; rs7067741; rs6584541; rs7067663; rs2148200; rs10883840; rs11191583; rs12415199; rs9919485; rs11191557; rs17094683; rs7895154; rs12355120; rs2153774; rs10786739; rs7915816; rs7081075; rs1807298; rs3861984; rs11191572; rs12571568; rs12416331; rs11191586; rs10883839; rs12766205; rs1163239; rs10883837; rs11191584; rs1163247; rs17115452; rs11191556; rs7909022; rs12775302; rs9633712; rs11191581; rs11191576; rs10883836; rs11191549; rs7095304; rs10883845; rs11191550; rs11191548; rs11191602; rs10748839; rs1141101; rs1055812; rs1141100; rs1141098; rs1141099; rs34351688; rs34394526; rs34058246; rs11191594; rs35224704; rs34747231; rs12774207; rs11191595; rs34699185; rs11280184; rs1163237; rs7073259; rs34064597; rs11191601; rs35525740; rs35291480; rs12264098; rs35978588; rs12241986; rs7091462; rs12774182; rs34756486; rs35695488; rs12252236; rs3834416; rs11191600; rs34136949; rs7080242; rs12763243; rs34003851; rs11191585; rs11191551; rs36111455; rs34966121; rs35464534; rs35541240; rs11191571; rs35913488; rs34223002; rs11440429; rs41287482; rs35653865; rs34963818; rs11191559; rs11191568; rs35436872; rs17795366; rs1163246; rs34060908; rs34963563; rs34915846; rs12780509; rs2153773; rs34211645; rs3736924; rs34758128; rs36059537; rs35302704; rs12255989; rs34104646; rs11191574; rs11191564; rs35745742; rs34644789; rs5787481; rs34863357; rs11191590; rs12774840; rs2148196; rs12763944; rs3215816; rs34207290; rs35752695; rs34445719; rs28419708; rs4421684; rs28516969; rs12265498; rs12767422; rs12772228; rs34908445; rs11191570; rs17115449; rs35195396; rs12243923; rs10883835; rs12779263; rs11302933; rs7091173; rs11375439; rs7071103; rs35146429; rs35338839; rs34268365; rs34130454; rs35898850; rs3861983; rs28404041; rs35621207; rs3736923; rs5787482; rs7075048; rs34307431; rs35348020; rs34349473; rs1773930; rs11191566; rs34870452; rs35078544; rs35123178; rs12265545; rs1163241; rs3949893; rs7904067; rs12775841; rs35821867; rs12775904; rs7915032; rs5028036; rs35254502; rs1163248; rs35365027; rs34876862; rs11191565; rs12772280; rs10709724; rs35085852; rs35351555; rs12774513; rs10710371; rs11296588; rs12243903; rs28605898; rs34241930; rs34549427; rs11451961; rs34403968; rs12761657; rs34397864; rs3062737; rs36092020; rs35109679; rs34011916; rs34435560; rs11191562; rs4917383; rs34067380; rs34202831; rs11191563; rs2148199; rs34133379; rs35763505; rs12414385; rs1163240; rs12262258; rs11191588; rs34664715; rs12414374; rs35133717; rs3837340; rs10614009; rs2153772; rs11191587; rs11403586; rs11191575; rs1060240; rs34588165; rs11191552; rs41317254; rs1163245; rs1064099; rs12268552; rs34833988; rs11191603; rs12253716; rs12412924; rs3841710; rs34551510; rs12246784; rs12781668; rs1064098; rs10458729; rs10786740; rs10786745; rs10883829; rs10883841; rs11191547; rs1163235; rs12261294; rs12571345; rs12785223; rs17115427; rs4307650; rs4917382; rs4917995; rs7074395; rs7092200; rs726010; rs763914; rs7921996; rs943035

# Metabolic_Enzyme_1_General_References:
7999131

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5933

# Metabolic_Enzyme_2_Name:
Putative adenosylhomocysteinase 3

# Metabolic_Enzyme_2_Synonyms:
S-adenosyl-L- homocysteine hydrolase 3; AdoHcyase 3

# Metabolic_Enzyme_2_Gene_Name:
KIAA0828

# Metabolic_Enzyme_2_Protein_Sequence:
>Putative adenosylhomocysteinase 3
MSVQVVSAAAAAKVPEVELKDLSPSEAESQLGLSTAAVGAMAPPAGGGDPEAPAPAAERP
PVPGPGSGPAAALSPAAGKVPQASAMKRSDPHHQHQRHRDGGEALVSPDGTVTEAPRTVK
KQIQFADQKQEFNKRPTKIGRRSLSRSISQSSTDSYSSAASYTDSSDDETSPRDKQQKNS
KGSSDFCVKNIKQAEFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQTA
VLMETLGALGAQCRWAACNIYSTLNEVAAALAESGFPVFAWKGESEDDFWWCIDRCVNVE
GWQPNMILDDGGDLTHWIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVN
DSVTKQKFDNLYCCRESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYV
TEIDPICALQACMDGFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGH
SNTEIDVASLRTPELTWERVRSQVDHVIWPDGKRIVLLAEGRLLNLSCSTVPTFVLSITA
TTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNK
NGPFKPNYYRY

# Metabolic_Enzyme_2_Number_of_Residues:
611

# Metabolic_Enzyme_2_Molecular_Weight:
66722

# Metabolic_Enzyme_2_Theoretical_pI:
7.39

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ether bonds
Function:  trialkylsulfonium hydrolase activity
Function:  adenosylhomocysteinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  one-carbon compound metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
S-adenosyl-L-homocysteine + H(2)O = L- homocysteine + adenosine

# Metabolic_Enzyme_2_Pathway:
map00271  Methionine metabolism;
 map00450  Selenoamino acid metabolism

# Metabolic_Enzyme_2_Reaction:
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF05221:AdoHcyase;
PF00670:AdoHcyase_NAD

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.3.1.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
4240145

# Metabolic_Enzyme_2_SwissProt_ID:
SAHH3_HUMAN (Q96HN2)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
Not Available

# Metabolic_Enzyme_2_Geneatlas_id:
Not Available

# Metabolic_Enzyme_2_hgnc_id:
Not Available

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_2_Gene_Sequence:
>1860 bp
GAGCCGGTGGTTGCAGCGGAGGCGGTGATGTCGGTGCAGGTTGTGTCAGCCGCGGCTGCC
GCCAAGGTGCCTGAGGTGGAGCTGAAGGACCTGAGCCCCTCCGAGGCGGAGTCGCAACTA
GGACTGAGCACGGCCGCCGTGGGCGCCATGGCCCCCCCGGCGGGCGGTGGAGACCCTGAG
GCTCCAGCTCCCGCCGCGGAGCGGCCCCCGGTCCCCGGCCCGGGCTCGGGGCCCGCCGCC
GCTCTCAGCCCCGCCGCCGGGAAGGTGCCTCAGGCGTCGGCCATGAAGCGGAGCGACCCA
CATCACCAGCACCAGCGGCACCGCGACGGCGGCGAGGCCCTGGTCAGCCCCGACGGCACC
GTCACCGAGGCGCCGCGCACAGTCAAGAAGATCCAGTTTGCTGACCAGAAGCAAGAATTC
AACAAACGTCCCACCAAAATTGGACGTCGCTCTTTGTCTCGTTCCATTTCTCAGTCATCT
ACTGACAGCTACAGCTCAGCGGCTTCATATACAGATAGCTCTGATGATGAGACATCGCCC
AGGGACAAGCAGCAAAAGAACTCTAAGGGAAGCAGTGACTTCTGTGTTAAGAACATCAAA
CAGGCAGAGTTTGGACGAAGAGAAATTGAAATTGCTGAACAAGAAATGCCTGCATTGATG
GCTTTGAGGAAGAGAGCTCAAGGAGAAAAGCCTTTGGCTGGAGCCAAAATCGTGGGTTGC
ACACACATCACTGCTCAGACTGCTGTGCTTATGGAAACTCTGGGTGCTCTGGGGGCCCAG
TGCCGATGGGCTGCCTGCAACATCTATTCCACTCTCAATGAAGTGGCTGCTGCTCTAGCA
GAAAGTGGATTTCCTGTTTTTGCCTGGAAGGGAGAGTCAGAAGATGACTTTTGGTGGTGT
ATCGATAGATGTGTGAATGTGGAGGGCTGGCAGCCAAACATGATCTTGGATGATGGAGGG
GATCTTACCCACTGGATTTATAAAAAGTATCCCAACATGTTTAAGAAAATCAAGGGCATA
GTAGAGGAGAGTGTTACTGGAGTTCACAGGCTGTACCAACTGTCCAAAGCTGGGAAGCTG
TGTGTTCCAGCCATGAATGTCAATGACTCAGTCACCAAACAGAAATTTGACAACCTCTAC
TGTTGCCGTGAATCAATTCTTGATGGACTTAAAAGGACAACAGACATGATGTTTGGTGGA
AAGCAAGTGGTAGTCTGTGGCTATGGAGAGGTGGGGAAAGGGTGCTGTGCTGCCCTGAAA
GCCATGGGCTCCATTGTGTATGTAACTGAAATTGACCCCATCTGTGCCCTGCAAGCCTGT
ATGGATGGATTTCGACTGGTGAAATTAAATGAGGTCATCCGACAAGTGGACATTGTTATT
ACCTGTACAGGTAACAAGAATGTGGTAACCAGAGAGCACTTGGACCGTATGAAGAATAGC
TGCATCGTTTGTAACATGGGACATTCCAACACAGAGATTGACGTGGCGAGTCTGCGGACA
CCAGAACTGACCTGGGAGCGAGTGAGATCTCAAGTTGACCATGTGATATGGCCTGATGGC
AAGAGGATAGTACTGCTGGCAGAGGGCCGCCTGCTGAACCTTAGCTGCTCCACAGTGCCT
ACATTTGTGCTCTCAATCACTGCTACTACTCAGGCTCTTGCCTTGATAGAGCTTTACAAT
GCTCCTGAGGGTCGCTATAAGCAGGATGTCTACCTGTTGCCCAAGAAGATGGATGAGTAT
GTGGCCAGCCTACACCTGCCTACCTTTGATGCCCACTTGACAGAGCTGACAGATGAACAG
GCCAAGTATCTGGGACTCAACAAGAATGGGCCCTTCAAGCCTAATTACTACAGGTATTAA


# Metabolic_Enzyme_2_GenBank_ID_Gene:
AB020635

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_2_Locus:
7q32.1

# Metabolic_Enzyme_2_SNPs:
rs4731575; rs4728164; rs1665105; rs12112383; rs1473236; rs1559486; rs1880854; rs2141075; rs2694572; rs822040; rs4731572; rs2718091; rs3734969; rs9641846; rs822038; rs6467240; rs6467233; rs891545; rs2566876; rs2718090; rs6953598; rs1000676; rs2718084; rs2402951; rs6467237; rs1526899; rs10954226; rs2012919; rs6969620; rs2402944; rs7794622; rs1541711; rs2896414; rs4728163; rs4731570; rs2566882; rs12667132; rs2694591; rs1526898; rs2718097; rs6966595; rs2896415; rs6974155; rs1609043; rs6467243; rs6467239; rs12540568; rs1526900; rs10248810; rs7800983; rs822039; rs2566879; rs17348939; rs17628482; rs6950279; rs11979476; rs6947322; rs10954231; rs9641849; rs7788327; rs10954227; rs1549788; rs2694570; rs2402945; rs2718100; rs17627941; rs17427959; rs2694574; rs7805353; rs4110091; rs13235749; rs12668958; rs7792317; rs6948252; rs2694585; rs11762085; rs2402947; rs10954230; rs2566885; rs10257620; rs6967464; rs6971917; rs4517061; rs7781902; rs17168214; rs6467241; rs2694576; rs6467236; rs974558; rs10954229; rs12534372; rs2566875; rs11773220; rs6949882; rs6980385; rs4731568; rs13245719; rs2718114; rs2566877; rs2303303; rs7789697; rs2566887; rs6467235; rs2718083; rs4731569; rs17552570; rs17552411; rs10249336; rs3928439; rs2718099; rs10954228; rs4338039; rs2718093; rs2718096; rs2103232; rs1991645; rs963465; rs9641847; rs17168734; rs6946288; rs9641850; rs7811141; rs6467234; rs12706872; rs11766298; rs2718085; rs9641851; rs1405475; rs10281269; rs10235589; rs10264209; rs2718089; rs2718086; rs10224011; rs17168750; rs12706879; rs10954224; rs12535502; rs12536256; rs9770833; rs4731567; rs12532192; rs7780886; rs13240723; rs2056694; rs17168512; rs6949950; rs7806089; rs7782348; rs11983827; rs10269495; rs13228005; rs2718098; rs6946270; rs7779572; rs7787531; rs10215998; rs10480492; rs13240872; rs11771587; rs4731571; rs2694589; rs4731566; rs2694586; rs7799667; rs12671820; rs2566881; rs721691; rs2694583; rs6944095; rs6946938; rs9649531; rs12154376; rs10255583; rs13235047; rs12706878; rs12112374; rs13243361; rs4460316; rs2463096; rs13225516; rs6953498; rs12706877; rs2718094; rs6958637; rs2718115; rs4440569; rs35381790; rs35695777; rs4728162; rs13226919; rs12536259; rs17168678; rs6944100; rs2402943; rs6942756; rs10237796; rs13246455; rs11770643; rs12533108; rs36033343; rs12706884; rs974557; rs10248733; rs6467242; rs2566878; rs9649530; rs2402946; rs7778993; rs7803052; rs10271956; rs2056693; rs2566883; rs2694571; rs2694590; rs12706880; rs1526897; rs11760275; rs10249742; rs2718088; rs13228930; rs4731565; rs1043148; rs1446314; rs34265960; rs2566884; rs34825108; rs13234716; rs5887417; rs10276667; rs13237450; rs35486062; rs2718092; rs13236141; rs11763340; rs10526470; rs13244886; rs2694584; rs12056066; rs35386880; rs10583733; rs12706873; rs35552948; rs2703097; rs28637615; rs35302708; rs35043755; rs5887423; rs35771438; rs35183043; rs10537645; rs2694578; rs13243489; rs13309956; rs9649533; rs35285871; rs35645930; rs11765453; rs13245699; rs35678215; rs34402215; rs34357178; rs10224918; rs34069719; rs11440633; rs35253341; rs34419391; rs5887420; rs2718117; rs13227401; rs34545127; rs13229264; rs2566889; rs34134186; rs2694588; rs11766893; rs34119954; rs36016296; rs13236139; rs9640854; rs34748419; rs35525446; rs11457350; rs13235721; rs34103750; rs12111832; rs34470956; rs13230585; rs2566880; rs34454055; rs34022136; rs13241934; rs13236035; rs35506900; rs10661940; rs13243483; rs10689917; rs10268256; rs13229015; rs34284898; rs35056717; rs13235668; rs34946923; rs35487046; rs35382981; rs10276901; rs12706881; rs12154848; rs7779327; rs35611732; rs10650322; rs35922521; rs34721141; rs6942616; rs2694577; rs13240434; rs11769045; rs34114985; rs6467238; rs10245502; rs35477492; rs11323551; rs35891284; rs35236990; rs12706874; rs13228836; rs10273064; rs34878710; rs28636722; rs35464810; rs34778910; rs2303304; rs34534484; rs35305688; rs13309724; rs35753023; rs13242624; rs34545652; rs35837581; rs35886223; rs35060087; rs28475451; rs36065880; rs9692086; rs2718116; rs34535486; rs35730873; rs28772714; rs12671819; rs35687709; rs10573827; rs34729253; rs13224964; rs34387388; rs3993423; rs34329339; rs35555009; rs35604507; rs12155238; rs10245510; rs13230006; rs35749606; rs13247394; rs5887419; rs35300462; rs34626657; rs2718095; rs34656052; rs34836433; rs35160763; rs35499576; rs35753672; rs35180865; rs10245484; rs13227798; rs35366945; rs36047105; rs35575921; rs1469554; rs34184431; rs34634565; rs34605112; rs35543406; rs34783919; rs13235827; rs34936807; rs34129720; rs34698607; rs10628531; rs7808914; rs10276656; rs34218104; rs5887416; rs10261099; rs34829322; rs34995893; rs35720899; rs4460315; rs34985505; rs35068503; rs34969591; rs13242524; rs34944147; rs34203815; rs4579470; rs13221770; rs13242637; rs5887425; rs12706882; rs2694573; rs11352933; rs13239013; rs13230002; rs35239026; rs34807363; rs34015816; rs28421993; rs35562807; rs12706883; rs34691806; rs13247573; rs3993422; rs6970267; rs2718113; rs35974655; rs36058920; rs34048833; rs11298188; rs34168159; rs13228824; rs34883234; rs1074590; rs35351067; rs4605985; rs34797175; rs35412146; rs11428994; rs35450194; rs13236334; rs7778277; rs13242723; rs34911717; rs10267792; rs34651338; rs11373631; rs7802713; rs34822917; rs35195965; rs34025224; rs12706870; rs28786973; rs28399138; rs1562290; rs13235928; rs4339576; rs34323262; rs35035148; rs35801870; rs35071037; rs34986300; rs2566888; rs5887426; rs35525239; rs7806246; rs10682674; rs35521435; rs2263406; rs11353507; rs10281707; rs11763056; rs1918166; rs35797517; rs11411466; rs36071728; rs34546094; rs10261662; rs34867290; rs11766497; rs11371543; rs11384557; rs35710833; rs35091143; rs34806898; rs7802714; rs13226007; rs9641848; rs34625300; rs13226649; rs36037913; rs5887415; rs36113794; rs34355222; rs10527531; rs36058039; rs13238821; rs28437865; rs11407963; rs28616609; rs35743744; rs12706875; rs35097530; rs6962787; rs34118673; rs12533541; rs11389356; rs35051098; rs2703095; rs10232890; rs11379395; rs34643315; rs34890000; rs34694658; rs35404531; rs7810723; rs34806455; rs34026893; rs35866593; rs10247803; rs11414828; rs5887424; rs11763325; rs35779079; rs34064858; rs12667455; rs2694575; rs2718112; rs34783708; rs10271957; rs11765864; rs34971920; rs34629871; rs11772187; rs35064108; rs3887099; rs36005479; rs4731573; rs2718101; rs13229872; rs36093290; rs9690544; rs34481793; rs35136112; rs10579412; rs35082865; rs35467311; rs13227656; rs10954225; rs7790641; rs13245810; rs33989909; rs34809861; rs34696153; rs3042852; rs35443669; rs12216567; rs35120382; rs13310010; rs34422629; rs34853082; rs34659337; rs35907574; rs10245503; rs2141074; rs34071272; rs11319368; rs13242529; rs972568; rs11375520; rs36100832; rs34285950; rs4731574; rs13242604; rs35756110; rs13241894; rs34071868; rs7808920; rs35775278; rs2566886; rs34100080; rs34134934; rs34719441; rs12706876; rs35640675; rs1918167; rs35859186; rs35654453; rs10653631; rs35112509; rs35782004; rs11975133; rs12248; rs35714254; rs4728160; rs587499; rs6467244; rs682299; rs691807; rs692686; rs6971551; rs6977752

# Metabolic_Enzyme_2_General_References:
10048485

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5934

# Metabolic_Enzyme_3_Name:
Adenosylhomocysteinase

# Metabolic_Enzyme_3_Synonyms:
S-adenosyl-L-homocysteine hydrolase; AdoHcyase

# Metabolic_Enzyme_3_Gene_Name:
AHCY

# Metabolic_Enzyme_3_Protein_Sequence:
>Adenosylhomocysteinase
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVET
AVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYF
KDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINV
NDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVI
ITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIG
HFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSN
SFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMS
CDGPFKPDHYRY

# Metabolic_Enzyme_3_Number_of_Residues:
432

# Metabolic_Enzyme_3_Molecular_Weight:
47717

# Metabolic_Enzyme_3_Theoretical_pI:
6.29

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ether bonds
Function:  trialkylsulfonium hydrolase activity
Function:  adenosylhomocysteinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  one-carbon compound metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine

# Metabolic_Enzyme_3_Pathway:
map00271  Methionine metabolism;
 map00450  Selenoamino acid metabolism

# Metabolic_Enzyme_3_Reaction:
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF05221:AdoHcyase;
PF00670:AdoHcyase_NAD

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.3.1.1

# Metabolic_Enzyme_3_GenBank_ID_Protein:
178277

# Metabolic_Enzyme_3_SwissProt_ID:
SAHH_HUMAN (P23526)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
AHCY

# Metabolic_Enzyme_3_Geneatlas_id:
AHCY

# Metabolic_Enzyme_3_hgnc_id:
HGNC:343

# Metabolic_Enzyme_3_PDB_ID:
1LI4

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Metabolic_Enzyme_3_Gene_Sequence:
>1299 bp
ATGTCTGACAAACTGCCCTACAAAGTCGCCGACATCGGCCTGGCTGCCTGGGGACGCAAG
GCCCTGGACATTGCTGAGAACGAGATGCCGGGCCTGATGCGTATGCGGGAGCGGTACTCG
GCCTCCAAGCCACTGAAGGGCGCCCGCATCGCTGGCTGCCTGCACATGACCGTGGAGACG
GCCGTCCTCATTGAGACCCTCGTCACCCTGGGTGCTGAGGTGCAGTGGTCCAGCTGCAAC
ATCTTCTCCACCCAGAACCATGCGGCGGCTGCCATTGCCAAGGCTGGCATTCCGGTGTAT
GCCTGGAAGGGCGAAACGGACGAGGAGTACCTGTGGTGCATTGAGCAGACCCTGTACTTC
AAGGACGGGCCCCTCAACATGATTCTGGACGACGGGGGCGACCTCACCAACCTCATCCAC
ACCAAGTACCCGCAGCTTCTGCCAGGCATCCGAGGCATCTCTGAGGAGACCACGACTGGG
GTCCACAACCTCTACAAGATGATGGCCAATGGGATCCTCAAGGTGCCTGCCATCAATGTC
AATGACTCCGTCACCAAGAGCAAGTTTGACAACCTCTATGGCTGCCGGGAGTCCCTCATA
GATGGCATCAAGCGGGCCACAGATGTGATGATTGCCGGCAAGGTAGCGGTGGTAGCAGGC
TATGGTGATGTGGGCAAGGGCTGTGCCCAGGCCCTGCGGGGTTTCGGAGCCCGCGTCATC
ATCACCGAGATTGACCCCATCAACGCACTGCAGGCTGCCATGGAGGGCTATGAGGTGACC
ACCATGGATGAGGCCTGTCAGGAGGGCAACATCTTTGTCACCACCACAGGCTGTATTGAC
ATCATCCTTGGCCGGCACTTTGAGCAGATGAAGGATGATGCCATTGTGTGTAACATTGGA
CACTTTGACGTGGAGATCGATGTCAAGTGGCTCAACGAGAACGCCGTGGAGAAGGTGAAC
ATCAAGCCGCAGGTGGACCGGTATCGGTTGAAGAATGGGCGCCGCATCATCCTGCTGGCC
GAGGGTCGGCTGGTCAACCTGGGTTGTGCCATGGGCCACCCCAGCTTCGTGATGAGTAAC
TCCTTCACCAACCAGGTGATGGCGCAGATCGAGCTGTGGACCCATCCAGACAAGTACCCC
GTTGGGGTTCATTTCCTGCCCAAGAAGCTGGATGAGGCAGTGGCTGAAGCCCACCTGGGC
AAGCTGAATGTGAAGTTGACCAAGCTAACTGAGAAGCAAGCCCAGTACCTGGGCATGTCC
TGTGATGGCCCCTTCAAGCCGGATCACTACCGCTACTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M61831

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_3_Locus:
20cen-q13.1

# Metabolic_Enzyme_3_SNPs:
rs13043752; rs4239; rs13245; rs35913265; rs819134; rs819147; rs864702; rs819159; rs7271501; rs866027; rs1205357; rs819155; rs6059756; rs1205352; rs1205366; rs819156; rs819158; rs819148; rs819157; rs17091705; rs819133; rs17091729; rs17091701; rs11906980; rs6059755; rs819151; rs4456777; rs3838022; rs6119486; rs1205354; rs17091698; rs819150; rs875650; rs35351212; rs17091693; rs819132; rs1205355; rs1205356; rs34602355; rs7273572; rs34906237; rs819171; rs819169; rs819175; rs819173; rs819146; rs819172; rs843902; rs819174; rs1093782; rs1093783; rs11552694; rs41312290; rs41301825; rs11552700; rs11552699; rs6088457; rs11552697; rs11552698; rs6058020; rs12506; rs3208589; rs3208572; rs1064500; rs35627251; rs1058794; rs1058802; rs14941; rs35038733; rs819154; rs34623965; rs11475294; rs6058019; rs819149; rs34897875; rs11479058; rs6119488; rs35828873; rs35598784; rs5841170; rs13036766; rs33975173; rs34804525; rs34481238; rs6142135; rs6120597; rs6088456; rs819152; rs41310000; rs6120599; rs6059753; rs34988314; rs11697391; rs819153; rs6141460; rs6119487; rs6141459; rs6142133; rs6059752; rs7354522; rs34053088; rs34858306; rs6088459; rs11475580; rs843900; rs6120595; rs11428878; rs36043935; rs35505406; rs6120598; rs6059751; rs6088458; rs35077167; rs2297750; rs11482163; rs8116219; rs34161456; rs6120601; rs6120594; rs6120596; rs6059758; rs6087569; rs7352962; rs34586407; rs2181683; rs13036969; rs34610457; rs13036959; rs819170; rs11467322; rs6120593; rs6088460; rs11473946; rs11458444; rs17091733; rs35234313; rs1205349; rs1205350; rs6059762; rs6120592; rs6120602; rs8118727; rs819142; rs819144; rs819145; rs819176; rs819177

# Metabolic_Enzyme_3_General_References:
2596825; 11780052; 9586999

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5235

# Metabolic_Enzyme_4_Name:
Deoxycytidine kinase

# Metabolic_Enzyme_4_Synonyms:
dCK

# Metabolic_Enzyme_4_Gene_Name:
DCK

# Metabolic_Enzyme_4_Protein_Sequence:
>Deoxycytidine kinase
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
DFKDKYESLVEKVKEFLSTL

# Metabolic_Enzyme_4_Number_of_Residues:
260

# Metabolic_Enzyme_4_Molecular_Weight:
30519

# Metabolic_Enzyme_4_Theoretical_pI:
4.88

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents

# Metabolic_Enzyme_4_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_4_Reaction:
NTP + deoxycytidine = NDP + dCMP

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01712:dNK

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.7.1.74

# Metabolic_Enzyme_4_GenBank_ID_Protein:
181510

# Metabolic_Enzyme_4_SwissProt_ID:
DCK_HUMAN (P27707)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
DCK

# Metabolic_Enzyme_4_Geneatlas_id:
DCK

# Metabolic_Enzyme_4_hgnc_id:
HGNC:2704

# Metabolic_Enzyme_4_PDB_ID:
1P62

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_4_Gene_Sequence:
>783 bp
ATGGCCACCCCGCCCAAGAGAAGCTGCCCGTCTTTCTCAGCCAGCTCTGAGGGGACCCGC
ATCAAGAAAATCTCCATCGAAGGGAACATCGCTGCAGGGAAGTCAACATTTGTGAATATC
CTTAAACAATTGTGTGAAGATTGGGAAGTGGTTCCTGAACCTGTTGCCAGATGGTGCAAT
GTTCAAAGTACTCAAGATGAATTTGAGGAACTTACAATGTCTCAGAAAAATGGTGGGAAT
GTTCTTCAGATGATGTATGAGAAACCTGAACGATGGTCTTTTACCTTCCAAACATATGCC
TGTCTCAGTCGAATAAGAGCTCAGCTTGCCTCTCTGAATGGCAAGCTCAAAGATGCAGAG
AAACCTGTATTATTTTTTGAACGATCTGTGTATAGTGACAGGTATATTTTTGCATCTAAT
TTGTATGAATCTGAATGCATGAATGAGACAGAGTGGACAATTTATCAAGACTGGCATGAC
TGGATGAATAACCAATTTGGCCAAAGCCTTGAATTGGATGGAATCATTTATCTTCAAGCC
ACTCCAGAGACATGCTTACATAGAATATATTTACGGGGAAGAAATGAAGAGCAAGGCATT
CCTCTTGAATATTTAGAGAAGCTTCATTATAAACATGAAAGCTGGCTCCTGCATAGGACA
CTGAAAACCAACTTCGATTATCTTCAAGAGGTGCCTATCTTAACACTGGATGTTAATGAA
GACTTTAAAGACAAATATGAAAGTCTGGTTGAAAAGGTCAAAGAGTTTTTGAGTACTTTG
TGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M60527

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_4_Locus:
4q13.3-q21.1

# Metabolic_Enzyme_4_SNPs:
rs4643786; rs16845677; rs1385986; rs936868; rs936869; rs1486271; rs6446999; rs4694362; rs6446988; rs10518080; rs10805074; rs7684954; rs12648166; rs4235090; rs2010401; rs7669445; rs4490428; rs7439745; rs1552381; rs16845668; rs11935198; rs4308342; rs3775289; rs7672935; rs6819369; rs12513206; rs1580469; rs7699819; rs2171195; rs7684573; rs7697366; rs13106279; rs17686997; rs11728260; rs7691350; rs7690840; rs7659473; rs9993633; rs6841923; rs9997995; rs6446989; rs11731434; rs12513202; rs6446998; rs2035576; rs2129173; rs12501375; rs11737567; rs7672339; rs16845626; rs7659998; rs1385987; rs7693891; rs7672954; rs4694360; rs4525938; rs1906021; rs11544786; rs34662212; rs5859247; rs13124044; rs13124045; rs3065775; rs35686785; rs1803484; rs13124290; rs5859246; rs28734949; rs10019874; rs4021444; rs34857131; rs34482223; rs36018698; rs11394166; rs11935525; rs35461637; rs28867977; rs12503595; rs7656043; rs35177789; rs34193080; rs13117017; rs34109101; rs35278579; rs35147498; rs11460671; rs7699712; rs28404918; rs11337561; rs34139336; rs4694363; rs3833976; rs34969740; rs34676003; rs35858453; rs35754685; rs35688113; rs36078513; rs28545112; rs9997790; rs4597793; rs35755135; rs34078875; rs4377559; rs7698012; rs2363439; rs12511143; rs11728201; rs35880082; rs11315015; rs35477149; rs28715337; rs11429170; rs7689110; rs34763060; rs2171194; rs35003502; rs34851032; rs11322673; rs7439562; rs4694361; rs35261981; rs34205711; rs2306744; rs7689093; rs28671303; rs28687395; rs12642438; rs1385985; rs3733399; rs6446977; rs6836323; rs7656269

# Metabolic_Enzyme_4_General_References:
1996353; 2013338; 9342341

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5232

# Metabolic_Enzyme_5_Name:
Cytosolic 5'-nucleotidase 1B

# Metabolic_Enzyme_5_Synonyms:
Cytosolic 5'-nucleotidase IB; cN1B; cN-IB; Autoimmune infertility-related protein

# Metabolic_Enzyme_5_Gene_Name:
NT5C1B

# Metabolic_Enzyme_5_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
BMSQTSLKQKKNEPGMRSSKESLEAEKRKESDKTGVRLSNQMRRAVNPNHSLRCCPFQGH
SSCRRCLCAAEGTALGPCHTIRIYIHMCLLWEQGQQITMMRGSQESSLRKTDSRGYLVRS
QWSRISRSPSTKAPSIDEPRSRNTSAKLPSSSTSSRTPSTSPSLHDSSPPPLSGQPSLQP
PASPQLPRSLDSRPPTPPEPDPGSRRSTKMQENPEAWAQGIVREIRQTRDSQPLEYSRTS
PTEWKSSSQRRGIYPASTQLDRNSLSEQQQQQREDEDDYEAAYWASMRSFYEKNPSCSRP
WPPKPKNAITIALSSCALFNMVDGRKIYEQEGLEKYMEYQLTNENVILTPGPAFRFVKAL
QYVNARLRDLYPDEQDLFDIVLMTNNHAQVGVRLINSVNHYGLLIDRFCLTGGKDPIGYL
KAYLTNLYIAADSEKVQEAIQEGIASATMFDGAKDMAYCDTQLRVAFDGDAVLFSDESEH
FTKEHGLDKFFQYDTLCESKPLAQGPLKGFLEDLGRLQKKFYAKNERLLCPIRTYLVTAR
SAASSGARVLKTLRRWGLEIDEALFLAGAPKSPILVKIRPHIFFDDHMFHIEGAQRLGSI
AAYGFNKKFSS

# Metabolic_Enzyme_5_Number_of_Residues:
610

# Metabolic_Enzyme_5_Molecular_Weight:
68804

# Metabolic_Enzyme_5_Theoretical_pI:
9.03

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels

# Metabolic_Enzyme_5_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_5_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_5_GenBank_ID_Protein:
13774961

# Metabolic_Enzyme_5_SwissProt_ID:
5NT1B_HUMAN (Q96P26)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
NT5C1B

# Metabolic_Enzyme_5_Geneatlas_id:
NT5C1B

# Metabolic_Enzyme_5_hgnc_id:
HGNC:17818

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1699 bp
GGGCAAAAATGTGGATAACAACAAAAGAATTTCAACAGGTAAAAAAATGAGTCAAACATC
TCTCAAACAGAAAAAGAATGAGCCCGGAATGAGGTCCTCAAAAGAGAGTCTAGAAGCAGA
AAAAAGAAAGGAATCTGACAAAACAGGAGTTCGTCTGAGCAATCAGGGATCACAAGAATC
ATCACTGCGGAAGACAGACTCTCGAGGGTACCTTGTGCGCAGTCAATGGTCTAGAATATC
CCGGAGCCCATCCACCAAGGCTCCATCCATAGATGAGCCTAGAAGCAGGAACACCAGTGC
TAAGCTCCCCAGCAGCTCCACGAGCTCCCGGACTCCATCCACCTCCCCAAGCCTGCATGA
CTCCTCACCGCCGCCGCTGTCCGGGCAGCCCTCGCTCCAGCCACCCGCGTCGCCCCAGCT
GCCCCGGTCGCTGGACTCGCGGCCTCCCACGCCCCCAGAGCCCGATCCTGGCTCCCGGCG
CAGCACCAAAATGCAAGAAAATCCGGAGGCCTGGGCCCAAGGCATCGTGCGGGAAATCCG
CCAGACCCGGGACTCGCAGCCGCTGGAATATTCGCGCACGTCCCCCACCGAGTGGAAGTC
CTCCAGCCAGCGCAGGGGGATCTACCCCGCCTCCACCCAGCTGGACCGCAACTCTCTGTC
CGAGCAGCAGCAGCAGCAGCGGGAGGACGAAGACGACTACGAAGCTGCCTACTGGGCATC
CATGAAGTCGTTCTACGAAAAGAACCCGAGCTGCTGGCGCCCCTGGCCGCCCAAACCCAA
GAACGCCATCACCATTGCTCTCTCATCCTGCGCGCTCTTCAACATGGTGGACGGCAGGAA
AATCTACGAGCAAGAGGGTCTGGAAAAGTACATGGAGTATCAGCTCACCAATGAGAACGT
CATCCTGACCCCGGGCCCGGCGTTCCGTTTCGTCAAGGCACTACAGTATGTCAATGCTAG
ACTCCGTGATCTATATCCTGATGAACAGGACTTATTTGATATTGTACTGATGACTAATAA
CCATGCCCAAGTGGGAGTGCGGCTTATAAACAGCGTCAATCACTACGGCTTACTGATTGA
CCGCTTCTGTCTGACCGGGGGAAAAGACCCCATTGGCTATTTGAAGGCATATCTTACCAA
CTTGTATATTGCTGCAGATTCTGAAAAAGTGCAAGAGGCAATACAAGAAGGTATTGCCTC
TGCGACAATGTTTGATGGAGCCAAAGACATGGCTTACTGTGACACTCAGCTCCGTGTAGC
CTTTGATGGGGATGCTGTCCTCTTCTCTGATGAGTCTGAACATTTTACCAAGGAGCATGG
GCTGGACAAATTCTTCCAGTATGATACATTATGTGAAAGTAAGCCTCTTGCTCAGGGTCC
CCTAAAAGGCTTTCTGGAAGATTTAGGCAGACTGCAAAAGAAGTTCTATGCCAAAAATGA
ACGGTTACTTTGTCCTATCAGGACCTACCTGGTTACAGCTAGGAGTGCAGCCAGTTCAGG
CGCCCGTGTGCTGAAAACCTTCCGACGCTGGGGTCTAGAGATAGACGAAGCTCTTTTCCT
TGCTGGAGCCCCCAAAAGTCCCATCTTGGTGAAGATCCGGCCCCACATCTTCTTTGATGA
CCACATGTTCCACATTGAAGGGGCACAGAGGTTAGGTTCCATCGCAGCTTATGGCTTTAA
TAAAAAATTCAGTAGTTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AF356185

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_5_Locus:
2p24.2

# Metabolic_Enzyme_5_SNPs:
rs3902946; rs16985301; rs16985306; rs3747660; rs2346137; rs6720633; rs7594728; rs6531109; rs6710367; rs7557821; rs4832608; rs11893074; rs16985296; rs7561652; rs2317857; rs16985292; rs16985290; rs6741218; rs11096544; rs35590292; rs10183289; rs17752103; rs11885013; rs17701334; rs16985293; rs11903725; rs7604190; rs4832609; rs7592099; rs16985311; rs16985310; rs3810839; rs17852342; rs34254789; rs7594519; rs34129467; rs7605480; rs35165251; rs7603601; rs34836771; rs34186303; rs35711606; rs35729409; rs34953851; rs11291136; rs28474708; rs3046807; rs34660980; rs35519366; rs3046840; rs35419885; rs7557722; rs4300829; rs7592233; rs13020403; rs36121694; rs34127788; rs11889898; rs13403096; rs13411442; rs1373776; rs16985281; rs16985284; rs17751951; rs2346135; rs2346136; rs34722188; rs35805648; rs3810838; rs3910894

# Metabolic_Enzyme_5_General_References:
11690631

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5935

# Metabolic_Enzyme_6_Name:
Putative adenosylhomocysteinase 2

# Metabolic_Enzyme_6_Synonyms:
S-adenosyl-L- homocysteine hydrolase 2; AdoHcyase 2; S-adenosylhomocysteine hydrolase-like 1; DC-expressed AHCY-like molecule

# Metabolic_Enzyme_6_Gene_Name:
AHCYL1

# Metabolic_Enzyme_6_Protein_Sequence:
>Putative adenosylhomocysteinase 2
MSMPDAMPLPGVGEELKQAKEIEDAEKYSFMATVTKAPKKQIQFADDMQEFTKFPTKTGR
RSLSRSISQSSTDSYSSAASYTDSSDDEVSPREKQQTNSKGSSNFCVKNIKQAEFGRREI
EIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVLIETLCALGAQCRWSACNIY
STQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTHWVYKK
YPNVFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDG
LKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGFRVVKL
NEVIRQVDVVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVR
SQVDHVIWPDGKRVVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQD
VYLLPKKMDEYVASLHLPSFDAHLTELTDDQAKYLGLNKNGPFKPNYYRY

# Metabolic_Enzyme_6_Number_of_Residues:
530

# Metabolic_Enzyme_6_Molecular_Weight:
58952

# Metabolic_Enzyme_6_Theoretical_pI:
6.87

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ether bonds
Function:  trialkylsulfonium hydrolase activity
Function:  adenosylhomocysteinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  one-carbon compound metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
S-adenosyl-L-homocysteine + H(2)O = L- homocysteine + adenosine

# Metabolic_Enzyme_6_Pathway:
map00271  Methionine metabolism;
 map00450  Selenoamino acid metabolism

# Metabolic_Enzyme_6_Reaction:
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF05221:AdoHcyase;
PF00670:AdoHcyase_NAD

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.3.1.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
16588687

# Metabolic_Enzyme_6_SwissProt_ID:
SAHH2_HUMAN (O43865)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
AHCYL1

# Metabolic_Enzyme_6_Geneatlas_id:
AHCYL1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:344

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Endoplasmic reticulum

# Metabolic_Enzyme_6_Gene_Sequence:
>1593 bp
ATGTCGATGCCTGACGCGATGCCGCTGCCCGGGGTCGGGGAGGAGCTGAAGCAGGCCAAG
GAGATCGAGGACGCCGAGAAGTACTCCTTCATGGCCACCGTCACCAAGGCGCCCAAGAAG
CAAATCCAGTTTGCTGATGACATGCAGGAGTTCACCAAATTCCCCACCAAAACTGGCCGA
AGATCTTTGTCTCGCTCGATCTCACAGTCCTCCACTGACAGCTACAGTTCAGCTGCATCC
TACACAGATAGCTCTGATGATGAGGTTTCTCCCCGAGAGAAGCAGCAAACCAACTCCAAG
GGCAGCAGCAATTTCTGTGTGAAGAACATCAAGCAGGCAGAATTTGGACGCCGGGAGATT
GAGATTGCAGAGCAAGACATGTCTGCTCTGATTTCACTCAGGAAACGTGCTCAGGGGGAG
AAGCCCTTGGCTGGTGCTAAAATAGTGGGCTGTACACACATCACAGCCCAGACAGCGGTG
TTGATTGAGACACTCTGTGCCCTGGGGGCTCAGTGCCGCTGGTCTGCTTGTAACATCTAC
TCAACTCAGAATGAAGTAGCTGCAGCACTGGCTGAGGCTGGAGTTGCAGTGTTCGCTTGG
AAGGGCGAGTCAGAAGATGACTTCTGGTGGTGTATTGACCGCTGTGTGAACATGGATGGG
TGGCAGGCCAACATGATCCTGGATGATGGGGGAGACTTAACCCACTGGGTTTATAAGAAG
TATCCAAACGTGTTTAAGAAGATCCGAGGCATTGTGGAAGAGAGCGTGACTGGTGTTCAC
AGGCTGTATCAGCTCTCCAAAGCTGGGAAGCTCTGTGTTCCGGCCATGAACGTCAATGAT
TCTGTTACCAAACAGAAGTTTGATAACTTGTACTGCTGCCGAGAATCCATTTTGGATGGC
CTGAAGAGGACCACAGATGTGATGTTTGGTGGGAAACAAGTGGTGGTGTGTGGCTATGGT
GAGGTAGGCAAGGGCTGCTGTGCTGCTCTCAAAGCTCTTGGAGCAATTGTCTACATTACC
GAAATCGACCCCATCTGTGCTCTGCAGGCCTGCATGGATGGGTTCAGGGTGGTAAAGCTA
AATGAAGTCATCCGGCAAGTCGATGTCGTAATAACTTGCACAGGAAATAAGAATGTAGTG
ACACGGGAGCACTTGGATCGCATGAAAAACAGTTGTATCGTATGCAATATGGGCCACTCC
AACACAGAAATCGATGTGACCAGCCTCCGCACTCCGGAGCTGACGTGGGAGCGAGTACGT
TCTCAGGTGGACCATGTCATCTGGCCAGATGGCAAACGAGTTGTCCTCCTGGCAGAGGGT
CGTCTACTCAATTTGAGCTGCTCCACAGTTCCCACCTTTGTTCTGTCCATCACAGCCACA
ACACAGGCTTTGGCACTGATAGAACTCTATAATGCACCCGAGGGGCGATACAAGCAGGAT
GTGTACTTGCTTCCTAAGAAAATGGATGAATACGTTGCCAGCTTGCATCTGCCATCATTT
GATGCCCACCTTACAGAGCTGACAGATGACCAAGCAAAATATCTGGGACTCAACAAAAAT
GGGCCATTCAAACCTAATTATTACAGATACTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AF315687

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_6_Locus:
1p13.2

# Metabolic_Enzyme_6_SNPs:
rs17551493; rs186724; rs3768480; rs7548583; rs720917; rs9429768; rs7538488; rs7514825; rs7553933; rs12077057; rs12075114; rs17025292; rs7550200; rs11102047; rs12566417; rs17025313; rs10857808; rs2298116; rs11588387; rs17668350; rs3754444; rs12084905; rs12090731; rs12077217; rs17025290; rs17025317; rs333074; rs167985; rs17025334; rs12089207; rs12093312; rs333082; rs6676611; rs17025345; rs12073761; rs12091710; rs17025328; rs7541329; rs3768478; rs333079; rs11102045; rs11544575; rs1418320; rs11544576; rs34932516; rs11424431; rs403648; rs404279; rs1804956; rs333078; rs34749267; rs193084; rs5776998; rs41280338; rs12076435; rs35533865; rs17025294; rs17611282; rs35263120; rs656878; rs11384766; rs6669183; rs17668509; rs34732614; rs417098; rs397017; rs34280839; rs34284174; rs34375964; rs377798; rs657325; rs34362438; rs12088989; rs396275; rs7517430; rs17611428; rs34585613; rs12408603; rs5776999; rs431097; rs35838523; rs179644; rs35658860; rs404275; rs12075746; rs35979464; rs34041834; rs387904; rs645979; rs34446452; rs443761; rs41280336; rs35423066; rs11428908; rs10159344; rs11349395; rs17025298; rs445885; rs443880; rs656499; rs36125467; rs333081; rs5777000; rs34394435; rs34617914; rs12044411; rs10715355; rs11102046; rs3737210; rs2173135; rs3806457; rs442976; rs1062657; rs34267468; rs11102043; rs11102048; rs12062571; rs12066280; rs12987; rs17025347; rs333075; rs35907078; rs394645; rs444477; rs450959; rs4838940; rs4839195; rs636380; rs7516357; rs7521290

# Metabolic_Enzyme_6_General_References:
11904675

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5805

# Metabolic_Enzyme_7_Name:
Purine nucleoside phosphorylase

# Metabolic_Enzyme_7_Synonyms:
Inosine phosphorylase; PNP

# Metabolic_Enzyme_7_Gene_Name:
NP

# Metabolic_Enzyme_7_Protein_Sequence:
>Purine nucleoside phosphorylase
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS

# Metabolic_Enzyme_7_Number_of_Residues:
289

# Metabolic_Enzyme_7_Molecular_Weight:
32118

# Metabolic_Enzyme_7_Theoretical_pI:
6.95

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  purine-nucleoside phosphorylase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_7_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_7_Reaction:
purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00896:Mtap_PNP

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.4.2.1

# Metabolic_Enzyme_7_GenBank_ID_Protein:
35565

# Metabolic_Enzyme_7_SwissProt_ID:
PNPH_HUMAN (P00491)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
NP

# Metabolic_Enzyme_7_Geneatlas_id:
NP

# Metabolic_Enzyme_7_hgnc_id:
HGNC:7892

# Metabolic_Enzyme_7_PDB_ID:
1RT9

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>870 bp
ATGGAGAACGGATACACCTATGAAGATTATAAGAACACTGCAGAATGGCTTCTGTCTCAT
ACTAAGCACCGACCTCAAGTTGCAATAATCTGTGGTTCTGGATTAGGAGGTCTGACTGAT
AAATTAACTCAGGCCCAGATCTTTGACTACAGTGAAATCCCCAACTTTCCTCGAAGTACA
GTGCCAGGTCATGCTGGCCGACTGGTGTTTGGGTTCCTGAATGGCAGGGCCTGTGTGATG
ATGCAGGGCAGGTTCCACATGTATGAAGGGTACCCACTCTGGAAGGTGACATTCCCAGTG
AGGGTTTTCCACCTTCTGGGTGTGGACACCCTGGTAGTCACCAATGCAGCAGGAGGGCTG
AACCCCAAGTTTGAGGTTGGAGATATCATGCTGATCCGTGACCATATCAACCTACCTGGT
TTCAGTGGTCAGAACCCTCTCAGAGGGCCCAATGATGAAAGGTTTGGAGATCGTTTCCCT
GCCATGTCTGATGCCTACGACCGGACTATGAGGCAGAGGGCTCTCAGTACCTGGAAACAA
ATGGGGGAGCAACGTGAGCTACAGGAAGGCACCTATGTGATGGTGGCAGGCCCCAGCTTT
GAGACTGTGGCAGAATGTCGTGTGCTGCAGAAGCTGGGAGCAGACGCTGTTGGCATGAGT
ACAGTACCAGAAGTTATCGTTGCACGGCACTGTGGACTTCGAGTCTTTGGCTTCTCACTC
ATCACTAACAAGGTCATCATGGATTATGAAAGCCTGGAGAAGGCCAACCATGAAGAAGTC
TTAGCAGCTGGCAAACAAGCTGCACAGAAATTGGAACAGTTTGTCTCCATTCTTATGGCC
AGCATTCCACTCCCTGACAAAGCCAGTTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
X00737

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_7_Locus:
14q13.1

# Metabolic_Enzyme_7_SNPs:
rs1049564; rs1130650; rs1049562; rs7785; rs1617940; rs1760940; rs1713420; rs1760935; rs1713422; rs1713421; rs3790064; rs3790065; rs1713429; rs17882804; rs17880405; rs1756369; rs12147688; rs8008133; rs17881431; rs17881345; rs7154909; rs17883821; rs17885781; rs1760934; rs17879107; rs17880844; rs17879913; rs17881184; rs17885714; rs17880480; rs17883253; rs17878900; rs1713426; rs17881356; rs1713427; rs1760933; rs3790062; rs17883795; rs17112168; rs17880290; rs12147906; rs17881554; rs17881206; rs1049700; rs17882836; rs12101049; rs17884106; rs12147035; rs34480769; rs3838361; rs3842517; rs1760939; rs17885917; rs17886095; rs1760938; rs17883294; rs17883604; rs8019880; rs17881280; rs35549071; rs35139440; rs17880503; rs7151666; rs10498268; rs1079375; rs1079376; rs11846743; rs11850059; rs11850069; rs12587218; rs12886203; rs12888804; rs12891271; rs13379232; rs13379234; rs1629478; rs17112384; rs17112385; rs1713459; rs1713460; rs1713461; rs1713462; rs17242655; rs17242662; rs17242669; rs1756365; rs1760930; rs1760931; rs1760941; rs1760942; rs2077153; rs2481768; rs35175606; rs35567022; rs7156659; rs755777

# Metabolic_Enzyme_7_General_References:
6087295; 3029074; 12928150; 2104852; 1384322; 8931706

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5229

# Metabolic_Enzyme_8_Name:
5'-nucleotidase precursor

# Metabolic_Enzyme_8_Synonyms:
Ecto-5'-nucleotidase; 5'-NT; CD73 antigen

# Metabolic_Enzyme_8_Gene_Name:
NT5E

# Metabolic_Enzyme_8_Protein_Sequence:
>5'nucleotidase precursor
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ

# Metabolic_Enzyme_8_Number_of_Residues:
574

# Metabolic_Enzyme_8_Molecular_Weight:
63368

# Metabolic_Enzyme_8_Theoretical_pI:
7.04

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  hydrolase activity, acting on ester bonds
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides

# Metabolic_Enzyme_8_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_8_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF02872:5_nucleotid_C;
PF00149:Metallophos

# Metabolic_Enzyme_8_Signals:
1-26

# Metabolic_Enzyme_8_Transmembrane_Regions:
556-573

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_8_GenBank_ID_Protein:
23897

# Metabolic_Enzyme_8_SwissProt_ID:
5NTD_HUMAN (P21589)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
NT5E

# Metabolic_Enzyme_8_Geneatlas_id:
NT5E

# Metabolic_Enzyme_8_hgnc_id:
HGNC:8021

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Metabolic_Enzyme_8_Gene_Sequence:
>1725 bp
ATGTGTCCCCGAGCCGCGCGGGCGCCCGCGACGCTACTCCTCGCCCTGGGCGCGGTGCTG
TGGCCTGCGGCTGGCGCCTGGGAGCTTACGATTTTGCACACCAACGACGTGCACAGCCGG
CTGGAGCAGACCAGCGAGGACTCCAGCAAGTGCGTCAACGCCAGCCGCTGCATGGGTGGC
GTGGCTCGGCTCTTCACCAAGGTTCAGCAGATCCGCCGCGCCGAACCCAACGTGCTGCTG
CTGGACGCCGGCGACCAGTACCAGGGCACTATCTGGTTCACCGTGTACAAGGGCGCCGAG
GTGGCGCACTTCATGAACGCCCTGCGCTACGATGCCATGGCACTGGGAAATCATGAATTT
GATAATGGTGTGGAAGGACTGATCGAGCCACTCCTCAAAGAGGCCAAATTTCCAATTCTG
AGTGCAAACATTAAAGCAAAGGGGCCACTAGCATCTCAAATATCAGGACTTTATTTGCCA
TATAAAGTTCTTCCTGTTGGTGATGAAGTTGTGGGAATCGTTGGATACACTTCCAAAGAA
ACCCCTTTTCTCTCAAATCCAGGGACAAATTTAGTGTTTGAAGATGAAATCACTGCATTA
CAACCTGAAGTAGATAAGTTAAAAACTCTAAATGTGAACAAAATTATTGCACTGGGACAT
TCGGGTTTTGAAATGGATAAACTCATCGCTCAGAAAGTGAGGGGTGTGGACGTCGTGGTG
GGAGGACACTCCAACACATTTCTTTACACAGGCAATCCACCTTCCAAAGAGGTGCCTGCT
GGGAAGTACCCATTCATAGTCACTTCTGATGATGGGCGGAAGGTTCCTGTAGTCCAGGCC
TATGCTTTTGGCAAATACCTAGGCTATCTGAAGATCGAGTTTGATGAAAGAGGAAACGTC
ATCTCTTCCCATGGAAATCCCATTCTTCTAAACAGCAGCATTCCTGAAGATCCAAGCATA
AAAGCAGACATTAACAAATGGAGGATAAAATTGGATAATTATTCTACCCAGGAATTAGGG
AAAACAATTGTCTATCTGGATGGCTCCTCTCAATCATGCCGCTTTAGAGAATGCAACATG
GGCAACCTGATTTGTGATGCAATGATTAACAACAACCTGAGACACACGGATGAAATGTTC
TGGAACCACGTATCCATGTGCATTTTAAATGGAGGTGGTATCCGGTCGCCCATTGATGAA
CGCAACAATGGCACAATTACCTGGGAGAACCTGGCTGCTGTATTGCCCTTTGGAGGCACA
TTTGACCTAGTCCAGTTAAAAGGTTCCACCCTGAAGAAGGCCTTTGAGCATAGCGTGCAC
CGCTACGGCCAGTCCACTGGAGAGTTCCTGCAGGTGGGCGGAATCCATGTGGTGTATGAT
CTTTCCCGAAAACCTGGAGACAGAGTAGTCAAATTAGATGTTCTTTGCACCAAGTGTCGA
GTGCCCAGTTATGACCCTCTCAAAATGGACGAGGTATATAAGGTGATCCTCCCAAACTTC
CTGGCCAATGGTGGAGATGGGTTCCAGATGATAAAAGATGAATTATTAAGACATGACTCT
GGTGACCAAGATATCAACGTGGTTTCTACATATATCTCCAAAATGAAAGTAATTTATCCA
GCAGTTGAAGGTCGGATCAAGTTTTCCACAGGAAGTCACTGCCATGGAAGCTTTTCTTTA
ATATTTCTTTCACTTTGGGCAGTGATCTTTGTTTTATACCAATAG

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X55740

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_8_Locus:
6q14-q21

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
2129526; 8566797; 2173922; 9651114

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5234

# Metabolic_Enzyme_9_Name:
5'(3')-deoxyribonucleotidase, cytosolic type

# Metabolic_Enzyme_9_Synonyms:
Cytosolic 5',3'-pyrimidine nucleotidase; Deoxy-5'-nucleotidase 1; dNT-1

# Metabolic_Enzyme_9_Gene_Name:
NT5C

# Metabolic_Enzyme_9_Protein_Sequence:
>5'3'deoxyribonucleotidase, cytosolic type
MARSVRVLVDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADK
VASVYEAPGFFLDLEPIPGALDAVREMNDLPDTQVFICTSPLLKYHHCVGEKYRWVEQHL
GPQFVERIILTRDKTVVLGDLLIDDKDTVRGQEETPSWEHILFTCCHNRHLVLPPTRRRL
LSWSDNWREILDSKRGAAQRE

# Metabolic_Enzyme_9_Number_of_Residues:
201

# Metabolic_Enzyme_9_Molecular_Weight:
23383

# Metabolic_Enzyme_9_Theoretical_pI:
6.63

# Metabolic_Enzyme_9_GO_Classification:
Not Available

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP

# Metabolic_Enzyme_9_Pathway:
Not Available

# Metabolic_Enzyme_9_Reaction:
Not Available

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_9_GenBank_ID_Protein:
7524492

# Metabolic_Enzyme_9_SwissProt_ID:
NT5C_HUMAN (Q8TCD5)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
NT5C

# Metabolic_Enzyme_9_Geneatlas_id:
NT5C

# Metabolic_Enzyme_9_hgnc_id:
HGNC:17144

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_9_Gene_Sequence:
>606 bp
ATGGCGCGGAGCGTGCGCGTGCTGGTGGACATGGACGGCGTCCTGGCCGACTTCGAGGCC
GGCCTCCTGCGGGGCTTCCGCCGCCGCTTCCCTGAGGAGCCGCACGTGCCGCTGGAGCAA
CGCCGCGGCTTCCTGGCCCGCGAGCAGTACCGCGCCCTGCGGCCCGACCTGGCGGATAAA
GTGGCCAGTGTGTACGAAGCCCCGGGCTTTTTCCTGGACCTGGAGCCCATCCCGGGAGCC
TTGGACGCTGTGCGGGAGATGAACGACCTACCGGACACGCAGGTCTTCATCTGCACCAGC
CCCCTGCTGAAGTACCACCACTGTGTGGGTGAGAAGTACCGCTGGGTGGAGCAGCACCTG
GGGCCCCAGTTCGTAGAACGAATTATCCTGACAAGGGACAAGACGGTGGTCTTGGGGGAC
CTGCTCATTGATGACAAGGACACAGTTCGAGGCCAGGAGGAGACCCCAAGCTGGGAGCAC
ATCTTGTTCACCTGCTGCCACAATCGGCACCTGGTCCTGCCCCCGACAAGGAGACGGCTG
CTCTCCTGGAGTGACAACTGGAGGGAGATCTTAGATAGCAAGCGCGGAGCTGCGCAGCGG
GAATGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AF154829

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_9_Locus:
17q25.1

# Metabolic_Enzyme_9_SNPs:
rs4788867; rs11868451; rs3736076; rs3736075; rs12453556; rs4789144; rs11652099; rs4789143; rs11541956; rs12945569; rs3188816; rs12946860; rs1048779; rs12943507; rs34746270; rs11541955; rs12945517; rs9910084; rs34454120; rs7406461; rs4788868; rs11868212; rs1551966; rs2291027; rs2291028; rs34338273; rs3752801; rs4412997; rs4789145; rs750843; rs750844; rs899316; rs899317

# Metabolic_Enzyme_9_General_References:
10681516; 12234672

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5912

# Metabolic_Enzyme_10_Name:
Adenosine kinase

# Metabolic_Enzyme_10_Synonyms:
AK; Adenosine 5'-phosphotransferase

# Metabolic_Enzyme_10_Gene_Name:
ADK

# Metabolic_Enzyme_10_Protein_Sequence:
>Adenosine kinase
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAED
KHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKA
AEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKAR
VCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGN
ETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFA
VLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPD
FH

# Metabolic_Enzyme_10_Number_of_Residues:
362

# Metabolic_Enzyme_10_Molecular_Weight:
40546

# Metabolic_Enzyme_10_Theoretical_pI:
6.67

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleoside kinase activity
Function:  adenosine kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  purine salvage
Process:  purine ribonucleoside salvage
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides

# Metabolic_Enzyme_10_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_10_Reaction:
ATP + adenosine = ADP + AMP

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00294:PfkB

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.7.1.20

# Metabolic_Enzyme_10_GenBank_ID_Protein:
1224125

# Metabolic_Enzyme_10_SwissProt_ID:
ADK_HUMAN (P55263)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
ADK

# Metabolic_Enzyme_10_Geneatlas_id:
ADK

# Metabolic_Enzyme_10_hgnc_id:
HGNC:257

# Metabolic_Enzyme_10_PDB_ID:
1BX4

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Not Available

# Metabolic_Enzyme_10_Gene_Sequence:
>1038 bp
ATGACGTCAGTCAGAGAAAATATTCTCTTTGGAATGGGAAATCCTCTGCTTGACATCTCT
GCTGTAGTGGACAAAGATTTCCTTGATAAGTATTCTCTGAAACCAAATGACCAAATCTTG
GCTGAAGACAAACACAAGGAACTGTTTGATGAACTTGTGAAAAAATTCAAAGTCGAATAT
CATGCTGGTGGCTCTACCCAGAATTCAATTAAAGTGGCTCAGTGGATGATTCAACAGCCA
CACAAAGCAGCAACATTTTTTGGATGCATTGGGATAGATAAATTTGGGGAGATCCTGAAG
AGAAAAGCTGCTGAAGCCCATGTGGATGCTCATTACTACGAGCAGAATGAGCAGCCAACA
GGAACTTGTGCTGCATGCATCACTGGTGACAACAGGTCCCTCATAGCTAATCTTGCTGCT
GCCAATTGTTATAAAAAGGAAAAACATCTTGATCTGGAGAAAAACTGGATGTTGGTAGAA
AAAGCAAGAGTTTGTTATATAGCAGGCTTTTTTCTTCACGTTTCCCCAGAGTCAGTATTA
AAGGTGGCTCACCATGCTTCTGAAAACAACAGGATTTTCACTTTGAATCTATCTGCACCG
TTTATTAGCCAGTTCTACAAGGAATCATTGATGAAAGTTATGCCTTATGTTGATATACTT
TTTGGAAATGAGACAGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGAC
ATTAAAGAGATAGCCAAAAAGACACAAGCCCTGCCAAAGATGAACTCAAAGAGGCAGCGA
ATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACT
GCTTTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGAT
GCATTTGTTGGAGGTTTTCTGTCTCAACTGGTCTCTGACAAGCCTCTGACTGAATGTATC
CGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAG
AAGCCAGACTTCCACTGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
U50196

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_10_Locus:
10q22|10q11-q24

# Metabolic_Enzyme_10_SNPs:
rs16931480; rs1189553; rs10824095; rs2169682; rs2894236; rs1904060; rs1904067; rs1904066; rs1871088; rs1908335; rs719624; rs1871085; rs1871087; rs2894234; rs1904064; rs871267; rs10824166; rs7350403; rs10824172; rs7090732; rs10824087; rs7894466; rs2395096; rs1898057; rs6480741; rs10740440; rs6480745; rs7098277; rs10509348; rs7079515; rs7909197; rs7899674; rs6480721; rs11597563; rs10740439; rs4451661; rs1898055; rs7079633; rs2126768; rs4390292; rs10824163; rs6480734; rs7083427; rs2169683; rs2395092; rs7072264; rs7092245; rs7922519; rs4746191; rs10824183; rs10762587; rs7100452; rs7094239; rs4564273; rs1898056; rs7096553; rs4237279; rs7087566; rs11000920; rs10762595; rs7068789; rs7100550; rs6480733; rs10762582; rs4323810; rs7098200; rs2306161; rs10824170; rs7084786; rs10824165; rs10762621; rs7923414; rs10824182; rs7916445; rs6480742; rs7082003; rs961321; rs10762624; rs10824094; rs7093532; rs7908160; rs2395095; rs6480749; rs4320897; rs10762606; rs9665468; rs10733903; rs10762601; rs11001022; rs10824133; rs10824119; rs4077282; rs10509350; rs10762640; rs4746181; rs10824195; rs7918318; rs4459229; rs6480739; rs4261231; rs10762605; rs7082872; rs3862535; rs6480727; rs7918927; rs2395087; rs10824120; rs10824186; rs7078351; rs7087368; rs7914902; rs4746214; rs1904061; rs11001105; rs10762615; rs7083534; rs10824177; rs7085940; rs10740437; rs4746182; rs10740436; rs11001043; rs2126760; rs11818050; rs6480726; rs10762612; rs7895133; rs7075643; rs7095850; rs10740443; rs4746221; rs10824185; rs4353215; rs2395097; rs2126763; rs7924176; rs7910153; rs7919277; rs7072220; rs10762636; rs10762622; rs11000931; rs4745739; rs3781255; rs10762588; rs10824138; rs10824218; rs10762638; rs2126765; rs6480731; rs4745749; rs4338470; rs7074939; rs7079709; rs4746207; rs7921187; rs11819334; rs11000960; rs11001089; rs4561146; rs11815260; rs10824193; rs10762629; rs10824135; rs7917790; rs10824105; rs11597376; rs11817779; rs7897750; rs11593868; rs4746216; rs7919166; rs11001052; rs12573619; rs10762620; rs10824197; rs7071324; rs10762596; rs11816566; rs7912162; rs7072504; rs11813905; rs10824161; rs2126767; rs10762603; rs10733895; rs7097320; rs11813953; rs7072012; rs10824122; rs7909915; rs12573590; rs4746177; rs10762639; rs726120; rs10824188; rs7913606; rs4745743; rs10740423; rs11001020; rs7075393; rs4746212; rs7923626; rs4746190; rs1556822; rs946186; rs7899920; rs10762630; rs10824134; rs12784355; rs16931294; rs2117791; rs2078036; rs12571088; rs10762607; rs10824192; rs10824137; rs11001028; rs7477710; rs10824098; rs946185; rs11814981; rs11001046; rs7916143; rs6480732; rs4745750; rs7914995; rs10509347; rs7069460; rs10740441; rs7075956; rs10762591; rs4376843; rs4281434; rs10824208; rs7901031; rs11000964; rs11818752; rs10824101; rs7099494; rs1904062; rs10762635; rs11813032; rs10824106; rs10824160; rs2126766; rs11001002; rs10762611; rs11000925; rs6480724; rs10762599; rs16931395; rs11000911; rs7917666; rs7896617; rs11816554; rs11000939; rs958620; rs12416316; rs10762641; rs10824130; rs7073742; rs12355686; rs11813815; rs2164367; rs11001109; rs9665469; rs7098337; rs10824124; rs10762619; rs10824092; rs1904065; rs12772532; rs10824174; rs7901055; rs4639878; rs1556821; rs11814426; rs6480723; rs12360119; rs10824152; rs11813920; rs10824164; rs7073340; rs10824143; rs10824103; rs4489684; rs10824210; rs12570185; rs16931536; rs1993861; rs10824151; rs12571589; rs16931460; rs11001005; rs10824144; rs7923592; rs11598232; rs10762626; rs10824128; rs10762581; rs7084139; rs1556820; rs1904058; rs10509351; rs7100084; rs11000924; rs11001018; rs12569971; rs7895587; rs2395078; rs12416497; rs10762631; rs11001053; rs11814705; rs11814063; rs10762593; rs9971034; rs16931332; rs11815536; rs11001111; rs11001007; rs4746196; rs7920097; rs16931462; rs7097778; rs12573807; rs11001099; rs11001092; rs11813221; rs7073139; rs11001034; rs12572721; rs10824102; rs1904063; rs11001004; rs10824108; rs10509349; rs10824194; rs10733904; rs10740432; rs6480740; rs3862536; rs12573198; rs7896660; rs11000922; rs10762600; rs7089391; rs12412109; rs10824096; rs10824153; rs7476181; rs11001047; rs6480729; rs10740420; rs4746192; rs7896152; rs7906603; rs7894143; rs10824221; rs2894235; rs10762608; rs7086014; rs10824129; rs11001096; rs7915999; rs7902519; rs4746188; rs11812862; rs2131955; rs2126769; rs6480722; rs11598022; rs10824146; rs10824090; rs12415957; rs11812826; rs12412071; rs4745751; rs7084204; rs7087290; rs13376718; rs10762577; rs7914783; rs10824154; rs12243059; rs7088329; rs11001029; rs11000921; rs10762586; rs1908333; rs11000928; rs7905039; rs35074621; rs12357589; rs11000948; rs10740431; rs11000997; rs11001006; rs7895292; rs11812696; rs12573068; rs11000914; rs7089625; rs7081350; rs7074449; rs11001045; rs4501938; rs7922635; rs7898073; rs7903786; rs10762637; rs12220238; rs12251845; rs12217890; rs12259556; rs6480748; rs11001115; rs16931364; rs11001059; rs10762583; rs11000899; rs11000966; rs10762613; rs4746194; rs4341485; rs6480744; rs9664463; rs12261738; rs12360399; rs12572648; rs7919517; rs11001102; rs10128407; rs10824097; rs11001085; rs12360087; rs4746180; rs6480728; rs12573347; rs11001014; rs11594742; rs11000977; rs10824107; rs10824198; rs11599616; rs10824147; rs16931492; rs10824212; rs4615968; rs12268556; rs11000996; rs4745738; rs12359456; rs16931504; rs11001003; rs956118; rs12415743; rs12261586; rs7091715; rs12356618; rs11001114; rs1871086; rs12241337; rs12569368; rs11001103; rs10740421; rs6480730; rs9299518; rs7900243; rs10824117; rs12254109; rs4746189; rs7897539; rs10762585; rs11000951; rs10824113; rs10824104; rs16931528; rs11817059; rs4745744; rs16931523; rs11597443; rs10824148; rs16931525; rs16931367; rs11000988; rs10762602; rs6480746; rs7905536; rs10762618; rs12256590; rs7069107; rs10824142; rs12098284; rs7091719; rs11819665; rs11000959; rs7091300; rs11819705; rs16931516; rs12252558; rs16931474; rs7919010; rs10824123; rs7913178; rs11000909; rs11000915; rs12243409; rs12572696; rs7920185; rs7897778; rs12569733; rs7067813; rs4746198; rs7096664; rs16931341; rs7094284; rs7903760; rs11000945; rs11001015; rs7088944; rs7897643; rs1908334; rs10824111; rs12415794; rs11001090; rs12217753; rs11591270; rs16931520; rs4745740; rs7088149; rs11000927; rs4746202; rs7076721; rs16931511; rs9651336; rs16931546; rs12779371; rs7902089; rs12569695; rs12253120; rs9664464; rs946184; rs10824116; rs10762614; rs12416580; rs4746209; rs11598266; rs4746210; rs7921832; rs16931468; rs11818734; rs10824169; rs11000992; rs7085860; rs11000936; rs11819396; rs4331029; rs10824136; rs10740442; rs1416101; rs10762594; rs11812834; rs12569856; rs12775658; rs10824171; rs7904939; rs10824140; rs7073432; rs16931449; rs12268312; rs10824110; rs11001112; rs11001078; rs7073227; rs10824099; rs12414029; rs4745747; rs7920006; rs4745745; rs12260506; rs12359289; rs12415761; rs11000990; rs11001087; rs4341483; rs11814484; rs11817882; rs11000901; rs11000980; rs11000946; rs12355188; rs7901569; rs10824112; rs10824100; rs16931465; rs10824149; rs2395091; rs10430473; rs11595136; rs11000999; rs10824109; rs10824168; rs1531; rs10430521; rs4745741; rs12242776; rs7895061; rs12773903; rs10762598; rs10824209; rs7905662; rs11815035; rs12354678; rs10824220; rs12098289; rs4746197; rs11000994; rs7099552; rs7069901; rs11000912; rs7071823; rs10824175; rs7083605; rs4746187; rs12569670; rs12356350; rs7918573; rs10824115; rs10824181; rs12570624; rs7092741; rs10824203; rs11819074; rs11001031; rs7910626; rs12415736; rs10762609; rs11001027; rs12268597; rs11001016; rs4746218; rs12570022; rs11000941; rs11000986; rs10824139; rs7086415; rs12354659; rs17747401; rs2126764; rs11599320; rs12414489; rs7080815; rs10824118; rs10824091; rs7901524; rs11812815; rs12572580; rs16931477; rs10762584; rs7904489; rs4745752; rs7906759; rs12572155; rs7084146; rs11516630; rs7901242; rs11001013; rs7074327; rs4746215; rs7898517; rs10824088; rs10824167; rs10824125; rs10824132; rs10824141; rs11599829; rs11000962; rs11594739; rs10824121; rs11813394; rs12357370; rs11000900; rs7904773; rs10824211; rs10762589; rs11000947; rs7091823; rs12252705; rs11000981; rs7087567; rs11001048; rs16931519; rs7918003; rs16931521; rs7085334; rs12265663; rs10762617; rs16931527; rs11001116; rs12411935; rs12779309; rs4746211; rs7898405; rs12242814; rs10762592; rs10762616; rs11001019; rs10430474; rs2395093; rs10824202; rs1538311; rs10824114; rs10740433; rs12573649; rs7907801; rs1529; rs11000934; rs10824150; rs10740438; rs16931538; rs11001001; rs7081573; rs11817959; rs11000987; rs7907267; rs6480743; rs7906779; rs11819130; rs16931490; rs10824190; rs2169684; rs11001008; rs11000954; rs11000916; rs7894697; rs16931472; rs1189552; rs2126762; rs1052039; rs28433006; rs12767624; rs10709030; rs7476928; rs10699958; rs35967107; rs4328165; rs12256125; rs35681751; rs6480750; rs34148029; rs35946213; rs34428151; rs36030657; rs34269690; rs3037403; rs28806480; rs34213308; rs35291653; rs12265290; rs10587775; rs11001010; rs10400100; rs5786147; rs35242280; rs34546969; rs35683991; rs10618104; rs34215048; rs35938247; rs768959; rs12769918; rs36029311; rs7909834; rs11000950; rs35036011; rs33912244; rs4746184; rs4369336; rs11000973; rs35746333; rs2027266; rs12264178; rs12768982; rs5786138; rs11427369; rs36100829; rs34310248; rs34469098; rs11470196; rs11000993; rs11310691; rs35270154; rs7392652; rs35240931; rs11001076; rs34868542; rs35677795; rs12253997; rs11001024; rs11361618; rs34483117; rs1016419; rs11001062; rs35389691; rs4746213; rs12770163; rs12242773; rs12250065; rs714446; rs7478561; rs11000983; rs35213595; rs35124446; rs12360425; rs11001041; rs7101087; rs12768640; rs34991446; rs11001107; rs34157587; rs34960972; rs11001063; rs6143984; rs11001033; rs10824216; rs7068038; rs11000963; rs12769277; rs12221297; rs34006036; rs35913987; rs35593805; rs11000958; rs35690083; rs12776428; rs12359909; rs35675013; rs34160937; rs17682987; rs11298231; rs28665887; rs34822835; rs10693309; rs12358321; rs11294383; rs35382240; rs11441752; rs11000932; rs3192342; rs10443948; rs34368934; rs16931389; rs4746219; rs7085007; rs16931551; rs12784339; rs34785655; rs35885564; rs34253447; rs34545592; rs35474264; rs35954951; rs12261116; rs1871083; rs4746220; rs12769928; rs35213605; rs34146097; rs11001025; rs1904059; rs35282438; rs34630297; rs35244559; rs36064398; rs12772349; rs35081895; rs10719538; rs12358053; rs12770150; rs10824219; rs4578321; rs11812645; rs11000944; rs11377985; rs9730888; rs11001039; rs35189522; rs11377715; rs10578956; rs12245560; rs11464387; rs11001088; rs1908336; rs2395089; rs11000918; rs7478196; rs11001093; rs35289591; rs35155141; rs10630238; rs11000935; rs11283273; rs11431842; rs11498031; rs12241229; rs12779690; rs35621346; rs35957820; rs11516631; rs35088225; rs28540400; rs35958238; rs3758511; rs11427347; rs35956325; rs11000905; rs12780859; rs34456914; rs12257326; rs11000910; rs2951091; rs11419041; rs35418682; rs35969519; rs34509827; rs34011472; rs11001073; rs13376894; rs16931407; rs11001066; rs3037448; rs34427535; rs12359976; rs11285474; rs28756681; rs34190731; rs11292901; rs34798510; rs12775686; rs7076019; rs12571515; rs35698592; rs10568623; rs7079178; rs35634749; rs35197598; rs11000998; rs34848917; rs7070345; rs35336446; rs35924345; rs34395307; rs35681211; rs34203173; rs7074078; rs11000949; rs12251148; rs11294980; rs34484828; rs7070707; rs5786139; rs35196181; rs7909032; rs34729493; rs34311007; rs35676834; rs34350496; rs35653353; rs35343842; rs35944635; rs34770422; rs35567434; rs11592151; rs34334128; rs4746208; rs12217863; rs12776780; rs10710680; rs34328974; rs11354070; rs35548449; rs35138612; rs11000937; rs5786136; rs34975658; rs11001051; rs5786148; rs12768637; rs12776762; rs11001032; rs35565783; rs35141788; rs5786145; rs34381749; rs34206298; rs16931588; rs11000972; rs34606636; rs35192408; rs11313699; rs11819453; rs12257167; rs35322063; rs34758567; rs11394734; rs4746193; rs34040400; rs12416047; rs7100239; rs35010757; rs11001050; rs35043540; rs35574014; rs35285241; rs12769920; rs11001077; rs35801937; rs9888065; rs12572719; rs12776511; rs11446202; rs11001023; rs4400738; rs34865824; rs3837336; rs12771556; rs35658711; rs11001042; rs9732237; rs34077396; rs12781732; rs12268885; rs16931430; rs34241739; rs11527234; rs11818880; rs12250504; rs12771964; rs4746185; rs11310513; rs7074915; rs35543329; rs7088493; rs34445084; rs12414124; rs10631417; rs35870828; rs35153697; rs12570068; rs2126761; rs11000976; rs12259418; rs35120068; rs34312133; rs4589228; rs34043389; rs34232307; rs11000965; rs34313197; rs12261108; rs12267421; rs35345171; rs12781539; rs1898054; rs34844657; rs12244479; rs11000933; rs12770253; rs1832436; rs35239000; rs4639879; rs35111858; rs11313781; rs12146408; rs7099493; rs36104559; rs12573253; rs12767938; rs34722640; rs35137924; rs35527525; rs35650817; rs34057132; rs34149159; rs11463660; rs11598404; rs2027265; rs41280418; rs34554027; rs12772421; rs11001068; rs11000961; rs10554301; rs11001113; rs10400099; rs35788249; rs11001074; rs11001049; rs35392498; rs11001079; rs11381604; rs34757853; rs11000984; rs10633386; rs28367539; rs35193175; rs5786149; rs36126508; rs11367583; rs34369353; rs12262949; rs35927711; rs949720; rs12769308; rs11001106; rs9733631; rs34985864; rs11527423; rs11289206; rs2894237; rs11320887; rs35035527; rs10596248; rs34829852; rs35566961; rs35148425; rs12259513; rs2395088; rs12777975; rs11001055; rs7078624; rs4746217; rs35385535; rs34440443; rs5786151; rs35822474; rs7478047; rs34684326; rs34778804; rs9731072; rs34447904; rs11458497; rs11361273; rs34029062; rs34301605; rs34969882; rs35062545; rs34668568; rs11596973; rs35067531; rs11000971; rs11000919; rs35038709; rs34848555; rs34943780; rs12775085; rs13376895; rs28550755; rs35630116; rs35480343; rs12358427; rs7476100; rs11001054; rs7916584; rs34117712; rs10646695; rs11001060; rs34025605; rs12782778; rs11000989; rs10550667; rs11001094; rs12254751; rs11001083; rs10592912; rs11001081; rs7914846; rs11001069; rs7083128; rs12771949; rs35844167; rs34807188; rs35351336; rs28798394; rs34628857; rs34464248; rs10653576; rs34498680; rs16931301; rs34644210; rs35318416; rs12357530; rs4506580; rs28886966; rs11527424; rs28711776; rs35836498; rs34575360; rs35138837; rs36106558; rs2894238; rs35333397; rs34945364; rs12261051; rs10546914; rs28705900; rs11000930; rs34022905; rs34369612; rs5786140; rs12415282; rs11001117; rs11451786; rs34788425; rs7476538; rs11000956; rs5786137; rs11000923; rs35465617; rs11001012; rs12355952; rs12267197; rs4303177; rs12254040; rs36070427; rs12770467; rs11000952; rs2027268; rs34323155; rs3037396; rs35856088; rs35278865; rs12357643; rs35046845; rs11434396; rs34777095; rs11597052; rs10667574; rs12763748; rs12414280; rs34427766; rs11498032; rs3037400; rs35287036; rs35285709; rs10710237; rs4746186; rs3037446; rs41405146; rs4746179; rs36119808; rs7072529; rs35194075; rs7094743; rs11300921; rs11000957; rs35630271; rs34844177; rs11597340; rs35918774; rs35774493; rs11599870; rs34794280; rs16931444; rs34535203; rs36041609; rs35654646; rs11357215; rs34600695; rs35167424; rs11000991; rs12764263; rs28620392; rs12765352; rs34417435; rs35499084; rs5786150; rs12771367; rs34006665; rs3957133; rs11000967; rs34878578; rs35302558; rs12255237; rs2395090; rs12098843; rs12220218; rs35091445; rs12251416; rs12764980; rs11598353; rs34605650; rs36016023; rs10693107; rs11596436; rs11000985; rs11492360; rs7100311; rs35008670; rs11001064; rs11000979; rs11001058; rs35705914; rs35798713; rs34320598; rs35102669; rs7090447; rs12261107; rs34385041; rs12267892; rs11593990; rs34053466; rs11312116; rs34287044; rs12767472; rs12359775; rs34820269; rs35056778; rs11000926; rs34396421; rs12355723; rs7083096; rs34992970; rs34064444; rs11000907; rs11001038; rs10578552; rs35152713; rs35733476; rs34480841; rs11001009; rs2395094; rs12775961; rs10558951; rs5786142; rs17744431; rs35872639; rs35658993; rs10535419; rs35203634; rs16931563; rs35781747; rs34577685; rs7082866; rs10527692; rs35945477; rs10565601; rs12248996; rs10657653; rs16931425; rs10612340; rs11000942; rs28673867; rs11001011; rs35803794; rs11000975; rs11380814; rs7093745; rs12782355; rs35927517; rs1140726; rs12262204; rs11000929; rs2027267; rs6480747; rs12247758; rs35796098; rs28457756; rs11000917; rs28599671; rs12767217; rs34601191; rs17746699; rs12098261; rs12255345; rs12250748; rs36073830; rs11297052; rs34377885; rs35708858; rs34454856; rs12241160; rs10669118; rs34336674; rs34920875; rs11001070; rs12415222; rs35421202; rs35759508; rs35249335; rs34947578; rs10400203; rs35521667; rs34161719; rs5786141; rs730660; rs11383205; rs34975150; rs2927517; rs7087005; rs11001021; rs3998213; rs12783210; rs35081179; rs10536957; rs34761801; rs11317030; rs11597174; rs35949478; rs7899397; rs12783738; rs17685047; rs11311986; rs35070470; rs28583797; rs35998695; rs11001095; rs12768800; rs34632561; rs7358249; rs34610545; rs719944; rs10559831; rs34130571; rs34419004; rs34492397; rs35960706; rs11000902; rs16931508; rs12356357; rs35369268; rs35568529; rs11000978; rs11368451; rs7909196; rs11596716; rs11591337; rs10612480; rs10710238; rs35423162; rs36067412; rs35503260; rs11001071; rs35720770; rs4746183; rs35744043; rs12250637; rs4448625; rs4746206; rs12772768; rs11377208; rs12781289; rs34033009; rs34705543; rs12770119; rs12261147; rs11510969; rs35092600; rs35989197; rs34809429; rs11001061; rs28588347; rs11356202; rs4745746; rs12221444; rs34137547; rs10534993; rs12765322; rs34589243; rs28891140; rs35036906; rs5786146; rs7101010; rs35057058; rs12763083; rs12241919; rs35010094; rs35210704; rs11001108; rs1131988; rs12776754; rs12764241; rs11285475; rs35913612; rs12773960; rs11000995; rs11279355; rs34842035; rs11592294; rs12219767; rs35370125; rs35785348; rs34133995; rs12243218; rs34631179; rs12763766; rs34123435; rs12251389; rs35116974; rs35655878; rs35281622; rs35717142; rs35955774; rs12249241; rs34740358; rs12261563; rs11492299; rs12767200; rs34775607; rs34490010; rs36042076; rs11447835; rs35273093; rs11402306; rs11814352; rs11388849; rs12241943; rs28422778; rs10689388; rs11000982; rs11597668; rs35085839; rs11278279; rs34137673; rs11001104; rs11000974; rs11001080; rs34027811; rs5786143; rs35689397; rs7898976; rs35973082; rs11001017; rs35190282; rs34346566; rs12775960; rs12769919; rs12267534; rs12251369; rs7071553; rs10698256; rs34893135; rs28612186; rs35236497; rs28842181; rs35388074; rs11000943; rs7081474; rs34535580; rs12269424; rs10682966; rs10670267; rs11000968; rs34357111; rs34359934; rs11001075; rs16931359; rs12356967; rs35233016; rs11001030; rs12255362; rs11372723; rs4638258; rs4341484; rs16931393; rs11001086; rs11000913; rs12243374; rs4745742; rs34770607; rs12778270; rs34660792; rs11000906; rs11001026; rs28473266; rs4746200; rs7089267; rs12764238; rs11001037; rs12359146; rs3837337; rs1051938; rs1051939; rs10824083; rs10824085; rs10824086; rs11000888; rs11000889; rs11000892; rs11000893; rs11000894; rs11000897; rs11817132; rs1189549; rs1189550; rs1189551; rs12256105; rs12358614; rs12572479; rs12778712; rs1338389; rs1766711; rs1766713; rs17676126; rs1774692; rs1871084; rs1874147; rs1908330; rs2788148; rs2894228; rs3812639; rs3829129; rs4638254; rs4746176; rs6480720; rs7071701; rs7079959; rs7099159; rs733350; rs7896323

# Metabolic_Enzyme_10_General_References:
8577746; 8917457; 9070863; 9843365; 12112843

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5937

# Metabolic_Enzyme_11_Name:
Adenosine deaminase

# Metabolic_Enzyme_11_Synonyms:
Adenosine aminohydrolase

# Metabolic_Enzyme_11_Gene_Name:
ADA

# Metabolic_Enzyme_11_Protein_Sequence:
>Adenosine deaminase
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL

# Metabolic_Enzyme_11_Number_of_Residues:
363

# Metabolic_Enzyme_11_Molecular_Weight:
40765

# Metabolic_Enzyme_11_Theoretical_pI:
5.80

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  adenosine deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_11_Specific_Function:
Adenosine + H(2)O = inosine + NH(3)

# Metabolic_Enzyme_11_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_11_Reaction:
adenosine + H2O = inosine + ammonia

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 3.5.4.4

# Metabolic_Enzyme_11_GenBank_ID_Protein:
28380

# Metabolic_Enzyme_11_SwissProt_ID:
ADA_HUMAN (P00813)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
ADA

# Metabolic_Enzyme_11_Geneatlas_id:
ADA

# Metabolic_Enzyme_11_hgnc_id:
HGNC:186

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_11_Gene_Sequence:
>1092 bp
ATGGCCCAGACGCCCGCCTTCGACAAGCCCAAAGTAGAACTGCATGTCCACCTAGACGGA
TCCATCAAGCCTGAAACCATCTTATACTATGGCAGGAGGAGAGGGATCGCCCTCCCAGCT
AACACAGCAGAGGGGCTGCTGAACGTCATTGGCATGGACAAGCCGCTCACCCTTCCAGAC
TTCCTGGCCAAGTTTGACTACTACATGCCTGCTATCGCGGGCTGCCGGGAGGCTATCAAA
AGGATCGCCTATGAGTTTGTAGAGATGAAGGCCAAAGAGGGCGTGGTGTATGTGGAGGTG
CGGTACAGTCCGCACCTGCTGGCCAACTCCAAAGTGGAGCCAATCCCCTGGAACCAGGCT
GAAGGGGACCTCACCCCAGACGAGGTGGTGGCCCTAGTGGGCCAGGGCCTGCAGGAGGGG
GAGCGAGACTTCGGGGTCAAGGCCCGGTCCATCCTGTGCTGCATGCGCCACCAGCCCAAC
TGGTCCCCCAAGGTGGTGGAGCTGTGTAAGAAGTACCAGCAGCAGACCGTGGTGGCCATT
GACCTGGCTGGAGATGAGACCATCCCAGGAAGCAGCCTCTTGCCTGGACATGTCCAGGCC
TACCAGGAGGCTGTGAAGAGCGGCATTCACCGTACTGTCCACGCCGGGGAGGTGGGCTCG
GCCGAAGTAGTAAAAGAGGCTGTGGACATACTCAAGACAGAGCGGCTGGGACACGGCTAC
CACACCCTGGAAGACCAGGCCCTTTATAACAGGCTGCGGCAGGAAAACATGCACTTCGAG
ATCTGCCCCTGGTCCAGCTACCTCACTGGTGCCTGGAAGCCGGACACGGAGCATGCAGTC
ATTCGGCTCAAAAATGACCAGGCTAACTACTCGCTCAACACAGATGACCCGCTCATCTTC
AAGTCCACCCTGGACACTGATTACCAGATGACCAAACGGGACATGGGCTTTACTGAAGAG
GAGTTTAAAAGGCTGAACATCAATGCGGCCAAATCTAGTTTCCTCCCAGAAGATGAAAAG
AGGGAGCTTCTCGACCTGCTCTATAAAGCCTATGGGATGCCACCTTCAGCCTCTGCAGGG
CAGAACCTCTGA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
X02994

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_11_Locus:
20q12-q13.11

# Metabolic_Enzyme_11_SNPs:
rs244076; rs11906526; rs427224; rs244078; rs2299686; rs2224999; rs379863; rs8119702; rs8119756; rs244075; rs2299691; rs2007515; rs2057637; rs762539; rs447833; rs2057638; rs6031682; rs6031690; rs6031686; rs2299688; rs6031689; rs371927; rs244079; rs2007720; rs1799880; rs2299692; rs395209; rs399159; rs2299690; rs11700291; rs929089; rs406383; rs2057639; rs967807; rs244073; rs2299694; rs452159; rs2157436; rs6031693; rs2299687; rs6017375; rs446125; rs2477898; rs6103795; rs6017378; rs445170; rs6031685; rs765215; rs6031695; rs1810751; rs2299697; rs433875; rs6031688; rs6094011; rs765216; rs244072; rs6031687; rs2299689; rs427483; rs427499; rs11907906; rs12480490; rs6103803; rs6031697; rs6017371; rs6031678; rs375379; rs384851; rs395896; rs450043; rs6094005; rs6031679; rs11698539; rs389308; rs11086932; rs6103804; rs6065738; rs1042360; rs11555566; rs7344760; rs6031698; rs394105; rs36216718; rs5841559; rs34853885; rs6017373; rs34665505; rs2765290; rs3831638; rs35553416; rs2515692; rs6031694; rs6103801; rs6103792; rs36222732; rs10561362; rs6103799; rs35009045; rs6094008; rs2007704; rs11474041; rs6103794; rs445725; rs11905649; rs6017376; rs457669; rs35383274; rs6103796; rs368253; rs6130653; rs6031691; rs11468750; rs8118045; rs6094004; rs455368; rs11484279; rs6031696; rs912912; rs6103800; rs6031684; rs445856; rs6094007; rs6017377; rs755144; rs6094009; rs11481765; rs382464; rs6103789; rs35712615; rs404898; rs6124654; rs929088; rs6031692; rs35863085; rs414146; rs6031681; rs413816; rs6103790; rs6031683; rs35436165; rs35935728; rs11698497; rs11373171; rs3091476; rs36013790; rs5841560; rs11907079; rs6103793; rs34344438; rs6017374; rs34081313; rs35535317; rs6130651; rs7353732; rs11484329; rs3041775; rs451499; rs3787359; rs11476459; rs7262528; rs6103797; rs34225524; rs11480982; rs34830340; rs6094010; rs6094006; rs3787360; rs6073497; rs11473840; rs13036408; rs34044957; rs244074; rs6103788; rs6017372; rs386512; rs35483396; rs11468701; rs2299695; rs244077; rs35505353; rs36102321; rs35545345; rs6103802; rs6103791; rs6103798; rs3831639; rs34833873; rs35784536; rs35587028; rs420183; rs6130652; rs10645831; rs36216716; rs435679; rs36216717; rs6031700; rs35153391; rs1061662; rs11699718; rs1886849; rs2071878; rs2148040; rs244081; rs244082; rs244086; rs244087; rs2664524; rs2664557; rs2664560; rs2664582; rs2664585; rs2868116; rs3180636; rs4810427; rs4810428; rs6017369; rs6031673; rs6031674; rs6031675; rs6031676; rs6031677; rs6031702; rs6031704; rs6065739; rs6094001; rs6094002; rs6094003; rs6094016; rs6094017; rs6103786; rs6103787; rs6103805; rs6103806; rs6130650; rs6130654; rs7266968; rs8118020; rs927784

# Metabolic_Enzyme_11_General_References:
6090454; 6546794; 3839456; 3028473; 11780052; 6688808; 8031011; 6208479; 3839802; 3182793; 2783588; 1284479; 8227344; 8299233; 8589684; 7599635; 9225964

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5236

# Metabolic_Enzyme_12_Name:
5'(3')-deoxyribonucleotidase, mitochondrial precursor

# Metabolic_Enzyme_12_Synonyms:
5',3'-nucleotidase, mitochondrial; Deoxy-5'-nucleotidase 2; dNT-2

# Metabolic_Enzyme_12_Gene_Name:
NT5M

# Metabolic_Enzyme_12_Protein_Sequence:
>5'3'deoxyribonucleotidase, mitochondrial precursor
MIRLGGWCARRLCSAAVPAGRRGAAGGLGLAGGRALRVLVDMDGVLADFEGGFLRKFRAR
FPDQPFIALEDRRGFWVSEQYGRLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMAS
LQNTDVFICTSPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDI
TGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRPC

# Metabolic_Enzyme_12_Number_of_Residues:
228

# Metabolic_Enzyme_12_Molecular_Weight:
25862

# Metabolic_Enzyme_12_Theoretical_pI:
8.12

# Metabolic_Enzyme_12_GO_Classification:
Not Available

# Metabolic_Enzyme_12_General_Function:
Not Available

# Metabolic_Enzyme_12_Specific_Function:
Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP

# Metabolic_Enzyme_12_Pathway:
Not Available

# Metabolic_Enzyme_12_Reaction:
Not Available

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_12_Signals:
1-15

# Metabolic_Enzyme_12_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_12_GenBank_ID_Protein:
9408106

# Metabolic_Enzyme_12_SwissProt_ID:
NT5M_HUMAN (Q9NPB1)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
NT5M

# Metabolic_Enzyme_12_Geneatlas_id:
NT5M

# Metabolic_Enzyme_12_hgnc_id:
HGNC:15769

# Metabolic_Enzyme_12_PDB_ID:
1Q92

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_12_Gene_Sequence:
>687 bp
ATGATCCGGCTGGGCGGCTGGTGTGCGCGGCGGCTCTGCAGCGCGGCGGTTCCCGCGGGG
CGGCGCGGGGCGGCGGGCGGGCTGGGCCTGGCGGGAGGCCGCGCCCTACGGGTGCTGGTG
GACATGGACGGCGTGCTGGCTGACTTCGAGGGCGGATTCCTCAGGAAGTTCCGCGCGCGC
TTTCCCGACCAGCCCTTCATCGCGCTGGAGGACCGGCGCGGCTTCTGGGTGTCGGAGCAG
TACGGCCGCCTGCGGCCAGGGCTGAGCGAGAAGGCCATCAGCATTTGGGAGTCAAAGAAT
TTCTTTTTTGAACTTGAGCCTCTGCCAGGGGCCGTGGAAGCTGTCAAGGAGATGGCCAGC
CTACAAAACACTGACGTCTTCATCTGCACAAGCCCCATCAAGATGTTCAAGTACTGTCCC
TATGAGAAGTATGCCTGGGTGGAGAAGTACTTTGGCCCTGACTTTCTGGAGCAGATTGTG
CTGACCAGAGACAAGACCGTGGTCTCTGCTGACCTTCTCATAGACGACCGGCCGGACATC
ACAGGGGCCGAGCCAACCCCCAGCTGGGAGCATGTCCTCTTCACCGCCTGCCACAACCAG
CACCTGCAGCTGCAGCCCCCCCGCCGCAGGCTGCACTCGTGGGCGGACGACTGGAAGGCC
ATTCTGGACAGCAAGCGGCCCTGCTGA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
AJ277557

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_12_Locus:
17p11.2

# Metabolic_Enzyme_12_SNPs:
rs2240876; rs758742; rs1860553; rs242243; rs6502579; rs7223473; rs11078384; rs7226068; rs10468464; rs12948296; rs1860552; rs9912109; rs9898622; rs7211968; rs17726703; rs9914692; rs3785502; rs11867932; rs3785504; rs17726673; rs11654778; rs16942153; rs17726858; rs11078382; rs3826302; rs2064060; rs6502580; rs7217503; rs9912172; rs3785506; rs9908168; rs11652902; rs9902505; rs4985707; rs6502576; rs6502578; rs16961564; rs7210344; rs16961516; rs242242; rs171394; rs12600778; rs9909111; rs7219752; rs6502577; rs12601631; rs11869054; rs17726924; rs9891799; rs11870836; rs11869507; rs11078383; rs4985706; rs7217162; rs9889738; rs9908338; rs7222555; rs9915883; rs7211243; rs9916133; rs9907857; rs9905836; rs11657817; rs9889298; rs7220829; rs9903425; rs9908360; rs9914424; rs9908124; rs11650700; rs11869079; rs7212369; rs9889367; rs7217114; rs9896977; rs9916676; rs16961561; rs12602026; rs9896970; rs9904396; rs9909850; rs10852849; rs11078385; rs6502575; rs242244; rs16961576; rs3203918; rs8082383; rs7212012; rs36114962; rs9889834; rs7226045; rs12602003; rs9894669; rs35712658; rs12941075; rs7210625; rs35320589; rs11655849; rs35470335; rs34668117; rs12943271; rs34446504; rs35945070; rs34219219; rs12951176; rs35554631; rs34408375; rs28825184; rs7218566; rs35917484; rs28880443; rs9904393; rs12601106; rs34579357; rs4985765; rs9907711; rs11343472; rs35579933; rs3087093; rs12951985; rs34993127; rs36088408; rs36091965; rs34100977; rs7220057; rs8080335; rs9901325; rs35720826; rs34886391; rs12949216; rs9898993; rs34121330; rs34513135; rs12936127; rs8067236; rs8081939; rs10617184; rs7211790; rs9914209; rs12951519; rs12603230; rs9913775; rs8068408; rs12452455; rs9901373; rs3063349; rs9913682; rs3785503; rs34156759; rs34776810; rs10574223; rs34836173; rs12951434; rs9709057; rs28813401; rs36146846; rs34709982; rs28616155; rs8082379; rs35267848; rs12951289; rs12948357; rs12950577; rs35861887; rs12948747; rs35096596; rs8080408; rs9898042; rs35930947; rs12948751; rs5741757; rs9889355; rs35575792; rs34018072; rs34407368; rs4985764; rs11395505; rs34676851; rs12951504; rs12950929; rs34025151; rs3837806; rs34247865; rs12946386; rs34209605; rs7219953; rs12951983; rs11400183; rs9912599; rs36056059; rs8071972; rs35039203; rs35326975; rs8071718; rs12946113; rs1009720; rs10852850; rs11078381; rs11078386; rs11871699; rs12450758; rs12451886; rs12452946; rs12602578; rs16961593; rs16961599; rs17648393; rs183596; rs190261; rs2041393; rs2058292; rs2191383; rs242246; rs242247; rs242249; rs242250; rs242251; rs624242; rs6502572; rs8067390; rs9892592; rs9899615; rs9905458; rs9909800; rs9914113

# Metabolic_Enzyme_12_General_References:
10899995; 12352955

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5233

# Metabolic_Enzyme_13_Name:
Cytosolic 5'-nucleotidase 1A

# Metabolic_Enzyme_13_Synonyms:
Cytosolic 5'-nucleotidase IA; cN1A; cN-IA; cN-I

# Metabolic_Enzyme_13_Gene_Name:
NT5C1A

# Metabolic_Enzyme_13_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
AMEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSR
ALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSED
VFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKV
REAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKA
HENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSW
GLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTA
PAKQAPSAQ

# Metabolic_Enzyme_13_Number_of_Residues:
368

# Metabolic_Enzyme_13_Molecular_Weight:
41021

# Metabolic_Enzyme_13_Theoretical_pI:
6.52

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_13_General_Function:
Not Available

# Metabolic_Enzyme_13_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia

# Metabolic_Enzyme_13_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_13_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
None

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_13_GenBank_ID_Protein:
12659324

# Metabolic_Enzyme_13_SwissProt_ID:
5NT1A_HUMAN (Q9BXI3)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
NT5C1A

# Metabolic_Enzyme_13_Geneatlas_id:
NT5C1A

# Metabolic_Enzyme_13_hgnc_id:
HGNC:17819

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_13_Gene_Sequence:
>1107 bp
ATGGAACCTGGGCAGCCCCGGGAGCCCCAGGAGCCCCGCGAGCCCGGGCCAGGAGCGGAG
ACCGCTGCGGCCCCGGTCTGGGAGGAAGCCAAGATTTTCTACGACAACCTCGCGCCCAAG
AAGAAACCCAAATCGCCCAAGCCTCAGAATGCAGTCACCATCGCTGTGTCCTCCCGAGCC
TTGTTTCGCATGGACGAGGAGCAGCAGATCTACACGGAGCAGGGCGTGGAGGAGTACGTG
CGCTACCAGCTGGAACATGAGAACGAACCCTTCAGTCCCGGGCCAGCCTTCCCTTTTGTG
AAGGCTCTGGAGGCCGTGAACAGGCGGCTGCGGGAGCTGTACCCTGATAGTGAGGACGTC
TTCGACATCGTCCTCATGACTAACAACCATGCTCAAGTGGGTGTCCGCCTCATCAACAGT
ATCAACCACTATGACCTGTTCATCGAGAGGTTCTGCATGACAGGTGGGAACAGCCCGATC
TGCTACCTCAAGGCCTATCACACCAACCTCTACTTGTCAGCCGATGCGGAAAAAGTGCGA
GAAGCCATTGATGAGGGGATCGCAGCTGCCACCATCTTCAGCCCCAGCAGGGATGTGGTT
GTGTCCCAGAGTCAGCTGCGCGTGGCCTTCGATGGGGACGCCGTGCTCTTCTCGGACGAG
TCGGAGCGCATCGTCAAGGCCCACGGGCTGGACCGATTCTTCGAGCATGAGAAGGCCCAC
GAGAACAAGCCTCTGGCTCAGGGCCCCTTAAAGGGCTTTCTGGAGGCACTGGGTAGGTTG
CAGAAGAAGTTCTACTCCAAAGGCCTGCGGCTGGAGTGCCCAATTCGTACCTACTTGGTG
ACAGCACGCAGTGCAGCCAGTTCCGGGGCCCGGGCTCTCAAGACCCTGCGCAGCTGGGGC
CTGGAGACAGATGAAGCCTTGTTCCTTGCTGGAGCGCCCAAGGGCCCTCTCCTTGAGAAG
ATCCGCCCACACATCTTCTTTGATGACCAGATGTTCCATGTGGCTGGGGCTCAGGAGATG
GGCACTGTGGCCGCCCATGTGCCTTATGGTGTGGCACAGACACCCCGGCGGACTGCACCT
GCAAAGCAGGCCCCATCTGCACAGTAG

# Metabolic_Enzyme_13_GenBank_ID_Gene:
AF331801

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_13_Locus:
1p34.3-p33

# Metabolic_Enzyme_13_SNPs:
rs4660340; rs784611; rs752667; rs1180272; rs1180271; rs784595; rs873917; rs1568146; rs1535031; rs3851911; rs17264901; rs784596; rs12566856; rs12406284; rs11807200; rs784597; rs784610; rs734497; rs3806428; rs784600; rs11809004; rs7553293; rs3806433; rs16826428; rs9660121; rs784599; rs3806429; rs784612; rs1533479; rs2871601; rs41264507; rs34479837; rs12035327; rs1180270; rs9439008; rs35574502; rs34779558; rs36025518; rs36123767; rs35625235; rs28507686; rs35550484; rs11206573; rs41264509; rs784598; rs34604809; rs1535030; rs5773668; rs1517187; rs12039176; rs28592113; rs784594; rs9438930; rs11306359; rs35355327; rs6684666; rs34908371; rs28667717; rs3806432; rs5773667; rs7416372; rs34045723; rs6672154; rs35002774; rs35256759; rs3806431; rs12042601; rs10465833; rs1062103; rs10839; rs10888919; rs10888929; rs11206525; rs1180275; rs1180277; rs12039225; rs12042356; rs12565281; rs13315; rs16826440; rs17501838; rs17560858; rs2281302; rs2746057; rs3207766; rs3806434; rs3916165; rs6663003; rs6703320; rs704769; rs736009; rs7419080; rs784601; rs784602; rs784613; rs784615; rs784616; rs784627; rs784629; rs784630; rs813052

# Metabolic_Enzyme_13_General_References:
11133996

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
7200

# Metabolic_Enzyme_14_Name:
Prothrombin precursor

# Metabolic_Enzyme_14_Synonyms:
Coagulation factor II[Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]

# Metabolic_Enzyme_14_Gene_Name:
F2

# Metabolic_Enzyme_14_Protein_Sequence:
>Prothrombin precursor
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE

# Metabolic_Enzyme_14_Number_of_Residues:
622

# Metabolic_Enzyme_14_Molecular_Weight:
70037

# Metabolic_Enzyme_14_Theoretical_pI:
5.70

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  thrombin activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
 ||
>>>
Process:  organismal physiological process
Process:  regulation of body fluids
Process:  hemostasis
Process:  blood coagulation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  extracellular region

# Metabolic_Enzyme_14_General_Function:
Not Available

# Metabolic_Enzyme_14_Specific_Function:
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C

# Metabolic_Enzyme_14_Pathway:
Not Available

# Metabolic_Enzyme_14_Reaction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00594:Gla;
PF00051:Kringle;
PF00089:Trypsin

# Metabolic_Enzyme_14_Signals:
1-24

# Metabolic_Enzyme_14_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 3.4.21.5

# Metabolic_Enzyme_14_GenBank_ID_Protein:
339641

# Metabolic_Enzyme_14_SwissProt_ID:
THRB_HUMAN (P00734)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
F2

# Metabolic_Enzyme_14_Geneatlas_id:
F2

# Metabolic_Enzyme_14_hgnc_id:
HGNC:3535

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_14_Gene_Sequence:
>1869 bp
ATGGCGCACGTCCGAGGCTTGCAGCTGCCTGGCTGCCTGGCCCTGGCTGCCCTGTGTAGC
CTTGTGCACAGCCAGCATGTGTTCCTGGCTCCTCAGCAAGCACGGTCGCTGCTCCAGCGG
GTCCGGCGAGCCAACACCTTCTTGGAGGAGGTGCGCAAGGGCAACCTAGAGCGAGAGTGC
GTGGAGGAGACGTGCAGCTACGAGGAGGCCTTCGAGGCTCTGGAGTCCTCCACGGCTACG
GATGTGTTCTGGGCCAAGTACACAGCTTGTGAGACAGCGAGGACGCCTCGAGATAAGCTT
GCTGCATGTCTGGAAGGTAACTGTGCTGAGGGTCTGGGTACGAACTACCGAGGGCATGTG
AACATCACCCGGTCAGGCATTGAGTGCCAGCTATGGAGGAGTCGCTACCCACATAAGCCT
GAAATCAACTCCACTACCCATCCTGGGGCCGACCTACAGGAGAATTTCTGCCGCAACCCC
GACAGCAGCACCACGGGACCCTGGTGCTACACTACAGACCCCACCGTGAGGAGGCAGGAA
TGCAGCATCCCTGTCTGTGGCCAGGATCAAGTCACTGTAGCGATGACTCCACGCTCCGAA
GGCTCCAGTGTGAATCTGTCACCTCCATTGGAGCAGTGTGTCCCTGATCGGGGGCAGCAG
TACCAGGGGCGCCTGGCGGTGACCACACATGGGCTCCCCTGCCTGGCCTGGGCCAGCGCA
CAGGCCAAGGCCCTGAGCAAGCACCAGGACTTCAACTCAGCTGTGCAGCTGGTGGAGAAC
TTCTGCCGCAACCCAGACGGGGATGAGGAGGGCGTGTGGTGCTATGTGGCCGGGAAGCCT
GGCGACTTTGGGTACTGCGACCTCAACTATTGTGAGGAGGCCGTGGAGGAGGAGACAGGA
GATGGGCTGGATGAGGACTCAGACAGGGCCATCGAAGGGCGTACCGCCACCAGTGAGTAC
CAGACTTTCTTCAATCCGAGGACCTTTGGCTCGGGAGAGGCAGACTGTGGGCTGCGACCT
CTGTTCGAGAAGAAGTCGCTGGAGGACAAAACCGAAAGAGAGCTCCTGGAATCCTACATC
GACGGGCGCATTGTGGAGGGCTCGGATGCAGAGATCGGCATGTCACCTTGGCAGGTGATG
CTTTTCCGGAAGAGTCCCCAGGAGCTGCTGTGTGGGGCCAGCCTCATCAGTGACCGCTGG
GTCCTCACCGCCGCCCACTGCCTCCTGTACCCGCCCTGGGACAAGAACTTCACCGAGAAT
GACCTTCTGGTGCGCATTGGCAAGCACTCCCGCACAAGGTACGAGCGAAACATTGAAAAG
ATATCCATGTTGGAAAAGATCTACATCCACCCCAGGTACAACTGGCGGGAGAACCTGGAC
CGGGACATTGCCCTGATGAAGCTGAAGAAGCCTGTTGCCTTCAGTGACTACATTCACCCT
GTGTGTCTGCCCGACAGGGAGACGGCAGCCAGCTTGCTCCAGGCTGGATACAAGGGGCGG
GTGACAGGCTGGGGCAACCTGAAGGAGACGTGGACAGCCAACGTTGGTAAGGGGCAGCCC
AGTGTCCTGCAGGTGGTGAACCTGCCCATTGTGGAGCGGCCGGTCTGCAAGGACTCCACC
CGGATCCGCATCACTGACAACATGTTCTGTGCTGGTTACAAGCCTGATGAAGGGAAACGA
GGGGATGCCTGTGAAGGTGACAGTGGGGGACCCTTTGTCATGAAGAGCCCCTTTAACAAC
CGCTGGTATCAAATGGGCATCGTCTCATGGGGTGAAGGCTGTGACCGGGATGGGAAATAT
GGCTTCTACACACATGTGTTCCGCCTGAAGAAGTGGATACAGAAGGTCATTGATCAGTTT
GGAGAGTAG

# Metabolic_Enzyme_14_GenBank_ID_Gene:
M17262

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_14_Locus:
11p11-q12

# Metabolic_Enzyme_14_SNPs:
rs5896; rs5898; rs3136452; rs3136532; rs5899; rs3136457; rs3136449; rs3136516; rs2282686; rs2070851; rs3136460; rs3136447; rs3136478; rs3136441; rs3136435; rs2070852; rs2282687; rs3136520; rs3136512; rs3136509; rs3136474; rs3136434; rs3136471; rs3136485; rs3136439; rs3136497; rs3136433; rs3136505; rs3136455; rs3136484; rs3136446; rs3136472; rs3136431; rs2070850; rs10838616; rs3136456; rs3136479; rs3136443; rs3136476; rs3136500; rs12574714; rs3136482; rs3136495; rs3136503; rs3136483; rs3136521; rs3136487; rs3136458; rs3136491; rs1799867; rs3136504; rs3136513; rs3136436; rs3136469; rs3136448; rs3136496; rs3136468; rs3136489; rs3136490; rs3136459; rs3136438; rs3136467; rs3136507; rs3136499; rs3136463; rs3136515; rs3136506; rs3136480; rs3136481; rs3136440; rs3136524; rs3136519; rs3136430; rs3136518; rs17854684; rs5897; rs1130873; rs5900; rs1799963; rs3136508; rs35768741; rs3136530; rs3136501; rs3136445; rs3136461; rs3136531; rs3136492; rs3891193; rs3136525; rs3136466; rs3136527; rs34428021; rs3136437; rs12787268; rs3136454; rs3136528; rs35690173; rs3136477; rs3136488; rs34747958; rs3136442; rs34204052; rs11038981; rs3926328; rs3136465; rs34647507; rs3136493; rs3136529; rs11038980; rs3136522; rs7123803; rs17847082; rs3136464; rs3136514; rs3926329; rs3136502; rs34284995; rs3136511; rs3136486; rs3136494; rs3136444; rs3136523; rs36050035; rs35150107; rs1129439; rs34296052; rs3136498; rs11438724; rs3136526; rs3136510; rs35817575; rs4752930; rs3136517; rs9794941; rs41275180; rs10838614; rs11038975; rs11038977; rs11038983; rs11038984; rs1130904; rs11604876; rs4076557; rs7938264

# Metabolic_Enzyme_14_General_References:
2825773; 6305407; 266717; 873923; 3759958; 2583108; 2374926; 8071320; 9214615; 10051558; 3771562; 7792730; 1421398; 7865694; 3242619; 2719946; 1354985; 3567158; 3801671; 1349838; 6405779; 10391209

# Metabolic_Enzyme_14_References:
16689530; 17150644

# Metabolic_Enzyme_15_ID:
8863

# Metabolic_Enzyme_15_Name:
CDNA FLJ27233 fis, clone SYN06481, highly similar to Adenosylhomocysteinase

# Metabolic_Enzyme_15_Synonyms:
Not Available

# Metabolic_Enzyme_15_Gene_Name:
Not Available

# Metabolic_Enzyme_15_Protein_Sequence:
>CDNA FLJ27233 fis, clone SYN06481, highly similar to Adenosylhomocysteinase
MYFLCFFCLFVSGRKWSRQFLLSFWCTVCSAHQGTIFLSLKIQFADQKQEFNKRPTKIGR
RSLSRSISQSSTDSYSSAASYTDSSDDETSPRDKQQKNSKGSSDFCVKNIKQAEFGRREI
EIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQTAVLMETLGALGAQCRWAACNIY
STLNEVAAALAESGFPVFAWKGESEDDFWWCIDRCVNVEGWQPNMILDDGGDLTHWIYKK
YPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDG
LKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDGFRLVKL
NEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVASLRTPELTWERVR
SQVDHVIWPDGKRIVLLAEGRLLNLSCSTMPTFVLSITATTQALALIELYNAPEGRYKQD
VYLLPKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNKNGPFKPNYYRY

# Metabolic_Enzyme_15_Number_of_Residues:
530

# Metabolic_Enzyme_15_Molecular_Weight:
59596

# Metabolic_Enzyme_15_Theoretical_pI:
8.05

# Metabolic_Enzyme_15_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ether bonds
Function:  trialkylsulfonium hydrolase activity
Function:  adenosylhomocysteinase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  one-carbon compound metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Coenzyme transport and metabolism

# Metabolic_Enzyme_15_Specific_Function:
S-adenosyl-L-homocysteine + H(2)O = L- homocysteine + adenosine

# Metabolic_Enzyme_15_Pathway:
map00271  Methionine metabolism
 map00450  Selenoamino acid metabolism

# Metabolic_Enzyme_15_Reaction:
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF05221:AdoHcyase
PF00670:AdoHcyase_NAD

# Metabolic_Enzyme_15_Signals:
1-31

# Metabolic_Enzyme_15_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 3.3.1.1

# Metabolic_Enzyme_15_GenBank_ID_Protein:
34527613

# Metabolic_Enzyme_15_SwissProt_ID:
Q6ZNS6_HUMAN (Q6ZNS6)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
Not Available

# Metabolic_Enzyme_15_Geneatlas_id:
Not Available

# Metabolic_Enzyme_15_hgnc_id:
Not Available

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_15_Gene_Sequence:
>1593 bp
ATGTATTTTCTCTGCTTTTTTTGTTTGTTTGTTTCAGGCAGGAAGTGGAGCCGTCAGTTC
CTGCTTTCATTCTGGTGTACTGTATGTTCTGCCCATCAAGGAACCATCTTTTTATCATTA
AAGATCCAGTTTGCTGACCAGAAGCAAGAATTCAACAAACGTCCCACCAAAATTGGACGT
CGCTCTTTGTCTCGTTCCATTTCTCAGTCATCTACTGACAGCTACAGCTCAGCGGCTTCA
TATACAGATAGCTCTGATGATGAGACATCGCCCAGGGACAAGCAGCAAAAGAACTCTAAG
GGAAGCAGTGACTTCTGTGTTAAGAACATCAAACAGGCAGAGTTTGGACGAAGAGAAATT
GAAATTGCTGAACAAGAAATGCCTGCATTGATGGCTTTGAGGAAGAGAGCTCAAGGAGAA
AAGCCTTTGGCTGGAGCCAAAATCGTGGGTTGCACACACATCACTGCTCAGACTGCTGTG
CTTATGGAAACTCTGGGTGCTCTGGGGGCCCAGTGCCGATGGGCTGCCTGCAACATCTAT
TCCACTCTCAATGAAGTGGCTGCTGCTCTAGCAGAAAGTGGATTTCCTGTTTTTGCCTGG
AAGGGAGAGTCAGAAGATGACTTTTGGTGGTGTATCGATAGATGTGTGAATGTGGAGGGC
TGGCAGCCAAACATGATCTTGGATGATGGAGGGGATCTTACCCACTGGATTTATAAAAAG
TATCCCAACATGTTTAAGAAAATCAAGGGCATAGTAGAGGAGAGTGTTACTGGAGTTCAC
AGGCTGTACCAACTGTCCAAAGCTGGGAAGCTGTGTGTTCCAGCCATGAATGTCAATGAC
TCAGTCACCAAACAGAAATTTGACAACCTCTACTGTTGCCGTGAATCAATTCTTGATGGA
CTTAAAAGGACAACAGACATGATGTTTGGTGGAAAGCAAGTGGTAGTCTGTGGCTATGGA
GAGGTGGGGAAAGGGTGCTGTGCTGCCCTGAAAGCCATGGGCTCCATTGTGTATGTAACT
GAAATTGACCCCATCTGTGCCCTGCAAGCCTGTATGGATGGATTTCGACTGGTGAAATTA
AATGAGGTCATCCGACAAGTGGACATTGTTATTACCTGTACAGGTAACAAGAATGTGGTA
ACCAGAGAGCACTTGGACCGTATGAAGAATAGCTGCATCGTTTGTAACATGGGACATTCC
AACACAGAGATTGACGTGGCGAGTCTGCGGACACCAGAACTGACCTGGGAGCGAGTGAGA
TCTCAAGTTGACCATGTGATATGGCCTGATGGCAAGAGGATAGTACTGCTGGCAGAGGGC
CGCCTGCTGAACCTTAGCTGCTCCACAATGCCTACATTTGTGCTCTCAATCACTGCTACT
ACTCAGGCTCTTGCCTTGATAGAGCTTTACAATGCTCCTGAGGGTCGCTATAAGCAGGAT
GTCTACCTGTTGCCCAAGAAGATGGATGAGTATGTGGCCAGCCTACACCTGCCTACCTTT
GATGCCCACTTGACAGAGCTGACAGATGAACAGGCCAAGTATCTGGGACTCAACAAGAAT
GGGCCCTTCAAGCCTAATTACTACAGGTATTAA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
AK130743

# Metabolic_Enzyme_15_Chromosome_Location:
Not Available

# Metabolic_Enzyme_15_Locus:
Not Available

# Metabolic_Enzyme_15_SNPs:
Not Available

# Metabolic_Enzyme_15_General_References:
Not Available

# Metabolic_Enzyme_15_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7549

# Macromolecular_Interacting_Partner_1_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
INS

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_1_Signals:
1-24

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
INS

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11p15.5

# Macromolecular_Interacting_Partner_1_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_1_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_1_References:
16873415

# Macromolecular_Interacting_Partner_2_ID:
7551

# Macromolecular_Interacting_Partner_2_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_2_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_2_Locus:
6p21.3

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_2_References:
16778150; 16788688; 16849509; 17021714

# Macromolecular_Interacting_Partner_3_ID:
7569

# Macromolecular_Interacting_Partner_3_Name:
Interleukin-6 precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF

# Macromolecular_Interacting_Partner_3_Gene_Name:
IL6

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Interleukin6 precursor
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYI
LDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLL
EFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQ
AQNQWLQDMTTHLILRSFKEFLQSSLRALRQM

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
212

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
23718

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.52

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interleukin-6 receptor binding
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
IL-6 is a cytokine with a wide variety of biological functions:it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00489:IL6

# Macromolecular_Interacting_Partner_3_Signals:
1-29

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
32674

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
IL6_HUMAN (P05231)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
IL6

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
IL6

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:6018

# Macromolecular_Interacting_Partner_3_PDB_ID:
2IL6

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>639 bp
ATGAACTCCTTCTCCACAAGCGCCTTCGGTCCAGTTGCCTTCTCCCTGGGGCTGCTCCTG
GTGTTGCCTGCTGCCTTCCCTGCCCCAGTACCCCCAGGAGAAGATTCCAAAGATGTAGCC
GCCCCACACAGACAGCCACTCACCTCTTCAGAACGAATTGACAAACAAATTCGGTACATC
CTCGACGGCATCTCAGCCCTGAGAAAGGAGACATGTAACAAGAGTAACATGTGTGAAAGC
AGCAAAGAGGCACTGGCAGAAAACAACCTGAACCTTCCAAAGATGGCTGAAAAAGATGGA
TGCTTCCAATCTGGATTCAATGAGGAGACTTGCCTGGTGAAAATCATCACTGGTCTTTTG
GAGTTTGAGGTATACCTAGAGTACCTCCAGAACAGATTTGAGAGTAGTGAGGAACAAGCC
AGAGCTGTCCAGATGAGTACAAAAGTCCTGATCCAGTTCCTGCAGAAAAAGGCAAAGAAT
CTAGATGCAATAACCACCCCTGACCCAACCACAAATGCCAGCCTGCTGACGAAGCTGCAG
GCACAGAACCAGTGGCTGCAGGACATGACAACTCATCTCATTCTGCGCAGCTTTAAGGAG
TTCCTGCAGTCCAGCCTGAGGGCTCTTCGGCAAATGTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
X04430

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_3_Locus:
7p21

# Macromolecular_Interacting_Partner_3_SNPs:
rs2069860; rs13306435; rs2069830; rs2069849; rs2069850; rs2069851; rs13306436; rs2069857; rs3087226; rs1474347; rs2069833; rs2069832; rs1554606; rs2069842; rs1548216; rs2069840; rs2066992; rs1474348; rs2069835; rs2069831; rs2069845; rs2069838; rs2069834; rs2069837; rs1524107; rs2069841; rs3087232; rs13306433; rs34277345; rs2069847; rs3087227; rs2069848; rs35361244; rs34249410; rs3087228; rs3087233; rs3087230; rs2069843; rs3087229; rs2069844; rs3087231; rs2069858; rs1800795; rs2069824; rs1800797; rs7802308; rs1800796; rs7802307; rs2069829; rs3087223; rs2069827; rs2069825; rs3087225; rs2069861; rs36215814; rs2234683; rs2069828; rs11544633; rs41477054; rs13306438; rs3915892; rs3915893; rs2069839; rs13306434; rs3087234; rs2069846; rs2069836; rs3087235; rs2069859; rs13447445; rs36215459; rs36215820; rs35081782; rs35178191; rs13447446; rs2069826; rs34328912; rs3087224; rs36215821; rs4335044; rs36215822; rs11973115; rs36215817; rs11445458; rs34224237; rs36215461; rs36215818; rs34280821; rs34012176; rs34709428; rs10242595; rs10499563; rs11766273; rs12700386; rs12700390; rs13438415; rs1546762; rs1546763; rs17147230; rs1880241; rs1880242; rs1880243; rs2069852; rs2069853; rs2069854; rs2069855; rs2069862; rs3087221; rs3087238; rs35610689; rs4398801; rs4719713; rs4719714; rs6461662; rs6946908; rs6963444; rs6963591; rs7458109; rs7784987; rs7801617; rs7805828; rs940367

# Macromolecular_Interacting_Partner_3_General_References:
3491322; 3500852; 3538015; 3023045; 3320204; 2789513; 3758081; 3266463; 1291290; 3279116; 2610854; 1883960; 7851440; 2472117; 2037043; 8555185; 9159484; 9118960

# Macromolecular_Interacting_Partner_3_References:
16788688; 16925466; 17065216

# Macromolecular_Interacting_Partner_4_ID:
7612

# Macromolecular_Interacting_Partner_4_Name:
Vascular endothelial growth factor A precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
VEGF-A; Vascular permeability factor; VPF

# Macromolecular_Interacting_Partner_4_Gene_Name:
VEGF

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Vascular endothelial growth factor A precursor
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD
IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM
SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPG
PHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
232

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
27043

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
9.08

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00341:PDGF

# Macromolecular_Interacting_Partner_4_Signals:
1-26

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
181971

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
VEGFA_HUMAN (P15692)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
VEGF

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
VEGF

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:12680

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell- associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>576 bp
ATGAACTTTCTGCTGTCTTGGGTGCATTGGAGCCTCGCCTTGCTGCTCTACCTCCACCAT
GCCAAGTGGTCCCAGGCTGCACCCATGGCAGAAGGAGGAGGGCAGAATCATCACGAAGTG
GTGAAGTTCATGGATGTCTATCAGCGCAGCTACTGCCATCCAATCGAGACCCTGGTGGAC
ATCTTCCAGGAGTACCCTGATGAGATCGAGTACATCTTCAAGCCATCCTGTGTGCCCCTG
ATGCGATGCGGGGGCTGCTGCAATGACGAGGGCCTGGAGTGTGTGCCCACTGAGGAGTCC
AACATCACCATGCAGATTATGCGGATCAAACCTCACCAAGGCCAGCACATAGGAGAGATG
AGCTTCCTACAGCACAACAAATGTGAATGCAGACCAAAGAAAGATAGAGCAAGACAAGAA
AATCCCTGTGGGCCTTGCTCAGAGCGGAGAAAGCATTTGTTTGTACAAGATCCGCAGACG
TGTAAATGTTCCTGCAAAAACACAGACTCGCGTTGCAAGGCGAGGCAGCTTGAGTTAAAC
GAACGTACTTGCAGATGTGACAAGCCGAGGCGGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
M32977

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_4_Locus:
6p12

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
2479986; 2479987; 1711045; 1791831; 1567395; 9054410; 9878851; 9450968; 10464055; 14574404; 7678805; 2584205; 10067980; 9207067; 9351807; 9922142; 9336848; 9634701; 11427521

# Macromolecular_Interacting_Partner_4_References:
16682012; 16799085; 17065216

# Macromolecular_Interacting_Partner_5_ID:
6982

# Macromolecular_Interacting_Partner_5_Name:
Adenosine A2a receptor

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
ADORA2A

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Adenosine A2a receptor
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
412

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
44708

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
8.05

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  nucleotide receptor activity, G-protein coupled
Function:  purinergic nucleotide receptor activity, G-protein coupled
Function:  adenosine receptor activity, G-protein coupled
Function:  A2A adenosine receptor activity, G-protein coupled
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_5_Signals:
1-30

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
177892

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
AA2AR_HUMAN (P29274)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
ADORA2A

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
ADORA2A

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:263

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1230 bp
ATGGGCTCCTCGGTGTACATCACGGTGGAGCTGGCCATTGCTGTGCTGGCCATCCTGGGC
AATGTGCTGGTGTGCTGGGCCGTGTGGCTCAACAGCAACCTGCAGAACGTCACCAACTAC
TTTGTGGTGTCACTGGCGGCGGCCGACATCGCAGTGGGTGTGCTCGCCATCCCCTTTGCC
ATCACCATCAGCACCGGGTTCTGCGCTGCCTGCCACGGCTGCCTCTTCATTGCCTGCTTC
GTCCTGGTCCTCACGCAGAGCTCCATCTTCAGTCTCCTGGCCATCGCCATTGACCGCTAC
ATTGCCATCCGCATCCCGCTCCGGTACAATGGCTTGGTGACCGGCACGAGGGCTAAGGGC
ATCATTGCCATCTGCTGGGTGCTGTCGTTTGCCATCGGCCTGACTCCCATGCTAGGTTGG
AACAACTGCGGTCAGCCAAAGGAGGGCAAGAACCACTCCCAGGGCTGCGGGGAGGGCCAA
GTGGCCTGTCTCTTTGAGGATGTGGTCCCCATGAACTACATGGTGTACTTCAACTTCTTT
GCCTGTGTGCTGGTGCCCCTGCTGCTCATGCTGGGTGTCTATTTGCGGATCTTCCTGGCG
GCGCGACGACAGCTGAAGCAGATGGAGAGCCAGCCTCTGCCGGGGGAGCGGGCACGGTCC
ACACTGCAGAAGGAGGTCCATGCTGCCAAGTCACTGGCCATCATTGTGGGGCTCTTTGCC
CTCTGCTGGCTGCCCCTACACATCATCAACTGCTTCACTTTCTTCTGCCCCGACTGCAGC
CACGCCCCTCTCTGGCTCATGTACCTGGCCATCGTCCTCTCCCACACCAATTCGGTTGTG
AATCCCTTCATCTACGCCTACCGTATCCGCGAGTTCCGCCAGACCTTCCGCAAGATCATT
CGCAGCCACGTCCTGAGGCAGCAAGAACCTTTCAAGGCAGCTGGCACCAGTGCCCGGGTC
TTGGCAGCTCATGGCAGTGACGGAGAGCAGGTCAGCCTCCGTCTCAACGGCCACCCGCCA
GGAGTGTGGGCCAACGGCAGTGCTCCCCACCCTGAGCGGAGGCCCAATGGCTATGCCCTG
GGGCTGGTGAGTGGAGGGAGTGCCCAAGAGTCCCAGGGGAACACGGGCCTCCCAGACGTG
GAGCTCCTTAGCCATGAGCTCAAGGGAGTGTGCCCAGAGCCCCCTGGCCTAGATGACCCC
CTGGCCCAGGATGGAGCAGGAGTGTCCTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
M97370

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_5_Locus:
22q11.23

# Macromolecular_Interacting_Partner_5_SNPs:
rs4990; rs17650937; rs4991; rs8192446; rs5751876; rs5996697; rs4822489; rs8184997; rs2236624; rs2267076; rs17004919; rs11704811; rs17004920; rs2236625; rs9624472; rs2330771; rs35327329; rs5760421; rs2533; rs35060421; rs35320474; rs4992; rs3211360; rs2532; rs4820587; rs5760420; rs35240883; rs17650801; rs4417803; rs34911378; rs28529486; rs4292176; rs5760418; rs7289199; rs35396475; rs34452689; rs3032740; rs10427623; rs35826617; rs13054761; rs13054390; rs34923252; rs13055638; rs13055629; rs13053574; rs1041749; rs1041750; rs11703436; rs12484115; rs13306115; rs13306116; rs17004921; rs17004922; rs17651129; rs17651189; rs2154609; rs2298382; rs2298383; rs3761421; rs3761422; rs3761423; rs3810617; rs4530; rs4822492; rs5751873; rs5751878; rs5760413; rs5760423; rs5760424; rs5760425; rs5760426; rs5760427; rs5760428; rs6004154; rs6004155; rs6004156; rs7285057; rs7287959; rs7290459; rs8141793; rs8142326; rs9612623; rs9612625; rs9624473

# Macromolecular_Interacting_Partner_5_General_References:
1331670; 8670304; 7775460; 10391209

# Macromolecular_Interacting_Partner_5_References:
16750892

# Macromolecular_Interacting_Partner_6_ID:
6980

# Macromolecular_Interacting_Partner_6_Name:
Adenosine A1 receptor

# Macromolecular_Interacting_Partner_6_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_6_Gene_Name:
ADORA1

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Adenosine A1 receptor
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
326

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
36512

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
8.75

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  nucleotide receptor activity, G-protein coupled
Function:  purinergic nucleotide receptor activity, G-protein coupled
Function:  adenosine receptor activity, G-protein coupled
Function:  A1 adenosine receptor activity, G-protein coupled
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_6_Signals:
1-33

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
256155

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
AA1R_HUMAN (P30542)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
ADORA1

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
ADORA1

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:262

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>981 bp
ATGCCGCCCTCCATCTCAGCTTTCCAGGCCGCCTACATCGGCATCGAGGTGCTCATCGCC
CTGGTCTCTGTGCCCGGGAACGTGCTGGTGATCTGGGCGGTGAAGGTGAACCAGGCGCTG
CGGGATGCCACCTTCTGCTTCATCGTGTCGCTGGCGGTGGCTGATGTGGCCGTGGGTGCC
CTGGTCATCCCCCTCGCCATCCTCATCAACATTGGGCCACAGACCTACTTCCACACCTGC
CTCATGGTTGCCTGTCCGGTCCTCATCCTCACCCAGAGCTCCATCCTGGCCCTGCTGGCA
ATTGCGGTGGACCGCTACCTCCGGGTCAAGATCCCTCTCCGGTACAAGATGGTGGTGACC
CCCCGGAGGGCGGCGGTGGCCATAGCCGGCTGCTGGATCCTCTCCTTCGTGGTGGGACTG
ACCCCTATGTTTGGCTGGAACAATCTGAGTGCGGTGGAGCGGGCCTGGGCAGCCAACGGC
AGCATGGGGGAGCCCGTGATCAAGTGCGAGTTCGAGAAGGTCATCAGCATGGAGTACATG
GTCTACTTCAACTTCTTTGTGTGGGTGCTCCCCCCGCTTCTCCTCATGGTCCTCATCTAC
CTGGAGGTCTTCTACCTAATCCGCAAGCAGCTCAACAAGAAGGTGTCGGCCTCCTCCGGC
GACCCGCAGAAGTACTATGGGAAGGAGCTGAAGATCGCCAAGTCGCTGGCCCTCATCCTC
TTCCTCTTTGCCCTCAGCTGGCTGCCTTTGCACATCCTCAACTGCATCACCCTCTTCTGC
CCGTCCTGCCACAAGCCCAGCATCCTTACCTACATTGCCATCTTCCTCACGCACGGCAAC
TCGGCCATGAACCCCATTGTCTATGCCTTCCGCATCCAGAAGTTCCGCGTCACCTTCCTT
AAGATTTGGAATGACCATTTCCGCTGCCAGCCTGCACCTCCCATTGACGAGGATCTCCCA
GAAGAGAGGCCTGATGACTAG

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
S45235

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_6_Locus:
1q32.1

# Macromolecular_Interacting_Partner_6_SNPs:
rs10920568; rs1874142; rs2364571; rs722915; rs903361; rs10800899; rs6427990; rs11582098; rs9660662; rs1494487; rs6702345; rs7555556; rs11590405; rs6677740; rs10920564; rs1494486; rs12411260; rs1494490; rs6696205; rs10920565; rs16851030; rs10800900; rs2886116; rs4570461; rs10920567; rs3898276; rs7538512; rs10920563; rs17510253; rs12023876; rs1494488; rs16851029; rs16850993; rs6674385; rs12047618; rs2131946; rs12072817; rs16850986; rs1874141; rs6427994; rs12744240; rs2014975; rs2201395; rs1845466; rs1494485; rs6427992; rs11585881; rs12757387; rs3766553; rs3766562; rs10920569; rs6686206; rs6427993; rs11576067; rs4950922; rs3766554; rs6677137; rs10920570; rs3753472; rs7549561; rs6683383; rs6701725; rs1417151; rs6698262; rs11579990; rs17465037; rs12135643; rs10158980; rs3766556; rs10920576; rs10158142; rs3753474; rs3766558; rs6688884; rs1587053; rs10800901; rs3766566; rs4423076; rs3753475; rs3766557; rs3766563; rs17464408; rs4950921; rs3753476; rs3766568; rs10399916; rs12026765; rs11587584; rs17511192; rs16851020; rs4950925; rs6413919; rs2172729; rs1890871; rs3766552; rs11800284; rs3766561; rs12138660; rs3766555; rs3766560; rs3753473; rs3766565; rs12566249; rs10158984; rs903364; rs16851008; rs12125460; rs4950920; rs11587032; rs12136486; rs17530497; rs12757371; rs12565957; rs17511046; rs7526646; rs5019958; rs7534251; rs3820147; rs16851017; rs12408764; rs10920573; rs12405501; rs10157751; rs11584369; rs3766564; rs12138603; rs11809836; rs6677396; rs10920574; rs17464968; rs1587054; rs16850997; rs3820150; rs12130154; rs3820148; rs12123037; rs11586408; rs4950924; rs6664108; rs1038984; rs7518889; rs11547175; rs11547176; rs17852405; rs2275349; rs11547177; rs11547174; rs1050284; rs35673121; rs12066195; rs35065380; rs5780143; rs12409721; rs16850994; rs954806; rs4950917; rs3079463; rs12067310; rs35610383; rs33912180; rs12127566; rs36111948; rs12724787; rs11373129; rs34147469; rs12093689; rs6692698; rs35323024; rs5780142; rs34713977; rs35936566; rs34408707; rs12026488; rs35845775; rs36123492; rs4430394; rs1494491; rs12759581; rs34405666; rs35650733; rs12135560; rs10598632; rs35617965; rs34874759; rs16850988; rs3079442; rs34476525; rs35760964; rs35557495; rs11806342; rs5780146; rs35159294; rs34893060; rs12742743; rs12044096; rs35981236; rs4020533; rs1389793; rs1961523; rs34201405; rs6676588; rs5780145; rs34657450; rs12026534; rs35286135; rs35480016; rs11590508; rs34794302; rs10574623; rs3079461; rs11429865; rs35004724; rs5780144; rs35885593; rs34166511; rs35283802; rs35483433; rs36047006; rs34682542; rs12143879; rs11315020; rs34723848; rs34191726; rs12729714; rs35155873; rs5780148; rs1417152; rs34083234; rs34589848; rs11351435; rs34898677; rs34326504; rs10712199; rs10920572; rs34426152; rs35145586; rs16851026; rs35824073; rs12119124; rs35696964; rs5780147; rs34844719; rs3834026; rs12403904; rs11280590; rs35960887; rs33933471; rs12064740; rs34639219; rs34226911; rs28855175; rs11580618; rs28666464; rs34431746; rs35195607; rs1106162; rs35699427; rs34779744; rs35070050; rs34636136; rs33996239; rs34723344; rs35689603; rs34372946; rs12726499; rs35038923; rs6427991; rs28605817; rs12025716; rs34162960; rs28721870; rs34583593; rs35927797; rs36070492; rs34920887; rs5780149; rs41264023; rs10525873; rs3841801; rs35504564; rs35517847; rs1494489; rs36047406; rs36073026; rs11589430; rs34228965; rs10638251; rs11412106; rs10920575; rs3835485; rs7544471; rs7534083; rs12095257; rs7544486; rs34457723; rs9659544; rs11373990; rs10753935; rs10920562; rs11588424; rs11807924; rs12028355; rs12070378; rs12087754; rs12097720; rs12139072; rs12145010; rs12724763; rs12737716; rs12743504; rs1532324; rs16851032; rs17465574; rs1999926; rs2071013; rs2071452; rs2250509; rs2642531; rs2642532; rs2788527; rs2788528; rs2788529; rs2791718; rs2791719; rs2791720; rs2814499; rs2855402; rs2855403; rs33945931; rs34702760; rs3737872; rs3737873; rs3737874; rs3737875; rs3737876; rs3737877; rs3737878; rs3753470; rs3753477; rs3753483; rs3766547; rs3766548; rs3766549; rs3766550; rs3766551; rs3820149; rs4950877; rs4950926; rs7514834; rs7538338; rs7545750; rs762625; rs883125; rs903356; rs923950

# Macromolecular_Interacting_Partner_6_General_References:
1530647; 1339301; 8300646

# Macromolecular_Interacting_Partner_6_References:
17039775; 17041727

# Macromolecular_Interacting_Partner_7_ID:
6985

# Macromolecular_Interacting_Partner_7_Name:
Adenosine A3 receptor

# Macromolecular_Interacting_Partner_7_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Name:
ADORA3

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Adenosine A3 receptor
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA
VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKR
VTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF
SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA
LSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC
VVCHPSDSLDTSIEKNSE

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
318

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
36185

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
9.04

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  nucleotide receptor activity, G-protein coupled
Function:  purinergic nucleotide receptor activity, G-protein coupled
Function:  adenosine receptor activity, G-protein coupled
Function:  A3 adenosine receptor activity, G-protein coupled
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
15-37
49-72
85-106
127-148
178-198
232-255
262-284

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
349449

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
AA3R_HUMAN (P33765)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
ADORA3

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
ADORA3

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:268

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>957 bp
ATGCCCAACAACAGCACTACTCTGTCATTGGCCAATGTTACCTACATCACCATGGAAATT
TTCATTGGACTCTGCGCCATAGTGGGCAACGTGCTGGTCATCTGCGTGGTCAAGCTGAAC
CCCAGCCTGCAGACCACCACCTTCTATTTCATTGTCTCTCTAGCCCTGGCTGACATTGCT
GTTGGGGTGCTGGTCATGCCTTTGGCCATTGTTGTCAGCCTGGGCATCACAATCCACTTC
TACAGCTGCCTTTTTATGACTTGCCTACTGCTTATCTTTACCCACGCCTCCATCATGTCC
TTGCTGGCCATCGCTGTGGACCGATACTTGCGGGTCAAGCTTACCGTCAGATACAAGAGG
GTCACCACTCACAGAAGAATATGGCTGGCCCTGGGCCTTTGCTGGCTGGTGTCATTCCTG
GTGGGATTGACCCCCATGTTTGGCTGGAACATGAAACTGACCTCAGAGTACCACAGAAAT
GTCACCTTCCTTTCATGCCAATTTGTTTCCGTCATGAGAATGGACTACATGGTATACTTC
AGCTTCCTCACCTGGATTTTCATCCCCCTGGTTGTCATGTGCGCCATCTATCTTGACATC
TTTTACATCATTCGGAACAAACTCAGTCTGAACTTATCTAACTCCAAAGAGACAGGTGCA
TTTTATGGACGGGAGTTCAAGACGGCTAAGTCCTTGTTTCTGGTTCTTTTCTTGTTTGCT
CTGTCATGGCTGCCTTTATCTATCATCAACTGCATCATCTACTTTAATGGTGAGGTACCA
CAGCTTGTGCTGTACATGGGCATCCTGCTGTCCCATGCCAACTCCATGATGAACCCTATC
GTCTATGCCTATAAAATAAAGAAGTTCAAGGAAACCTACCTTTTGATCCTCAAAGCCTGT
GTGGTCTGCCATCCCTCTGATTCTTTGGACACAAGCATTGAGAAGAATTCTGAGTAG

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
L20463

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_7_Locus:
1p13.2

# Macromolecular_Interacting_Partner_7_SNPs:
rs2800889; rs35511654; rs2275797; rs2229155; rs1415792; rs1415793; rs923; rs1544223; rs3394; rs1544224; rs3393; rs7737; rs9025; rs2252739; rs2800907; rs2065992; rs1361134; rs2798566; rs2800898; rs2800908; rs2095731; rs3767602; rs7547951; rs7544118; rs1361133; rs1780556; rs6684144; rs7517018; rs12127443; rs2275796; rs17027794; rs6672858; rs6537702; rs3767601; rs1361135; rs2789539; rs2252740; rs2800888; rs6659177; rs3767597; rs2032007; rs17027796; rs2789541; rs1628597; rs7549031; rs2262952; rs2252198; rs2800906; rs3767599; rs2252197; rs2032006; rs1962125; rs2800902; rs2786996; rs10857885; rs10857886; rs10857887; rs10776728; rs11102286; rs2298191; rs10776727; rs17027791; rs35986308; rs2789537; rs17852706; rs35789323; rs1417372; rs1591993; rs41282520; rs3908963; rs41282522; rs2298190; rs2789540; rs7512445; rs10697750; rs11434724; rs11434889; rs11434726; rs12137500; rs34799830; rs11434722; rs11804136; rs28651435; rs11311759; rs6660209; rs41282516; rs12125678; rs12126504; rs6678079; rs10697753; rs35262507; rs11321711; rs10602162; rs11434888; rs11337394; rs35344043; rs34457698; rs35537319; rs6668383; rs10686710; rs10697749; rs11434890; rs34492052; rs34460629; rs10596470; rs11434725; rs35259782; rs10686711; rs10602166; rs10602160; rs35611547; rs10697748; rs10618863; rs2486265; rs41290394; rs12136686; rs28528074; rs10614217; rs11434892; rs35767792; rs12126471; rs7548753; rs35584333; rs11434723; rs1780557; rs10602164; rs3831359; rs11273132; rs28760561; rs34567608; rs34093957; rs34272338; rs10686709; rs10602163; rs10686708; rs28757604; rs41282518; rs10614218; rs11434891; rs2488943; rs35689000; rs34693250; rs11314583; rs3835605; rs2265691; rs11102285; rs3216055; rs34273340; rs10711590; rs3904838; rs34622560; rs5777061; rs35606913; rs34225315; rs35077141; rs1054680; rs10857888; rs10857889; rs10857890; rs11102281; rs11102284; rs11102290; rs11102291; rs11102292; rs11576988; rs11810580; rs12039025; rs12042310; rs12142663; rs12566343; rs1361136; rs1419091; rs1538251; rs17027773; rs17027867; rs17027880; rs2211494; rs2298189; rs2786992; rs2786994; rs2786995; rs2800886; rs4593826; rs4839139; rs6537704; rs6537705; rs6692745; rs6703267

# Macromolecular_Interacting_Partner_7_General_References:
8399349; 8234299; 12975309; 11214319

# Macromolecular_Interacting_Partner_7_References:
16805847; 16956430

# Macromolecular_Interacting_Partner_8_ID:
7828

# Macromolecular_Interacting_Partner_8_Name:
Orexin precursor

# Macromolecular_Interacting_Partner_8_Synonyms:
Hypocretin; Hcrt[Contains: Orexin-A; Hypocretin- 1; Hcrt1; Orexin-B; Hypocretin-2; Hcrt2]

# Macromolecular_Interacting_Partner_8_Gene_Name:
HCRT

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Orexin precursor
MNLPSTKVSWAAVTLLLLLLLLPPALLSSGAAAQPLPDCCRQKTCSCRLYELLHGAGNHA
AGILTLGKRRSGPPGLQGRLQRLLQASGNHAAGILTMGRRAGAEPAPRPCLGRRCSAPAA
ASVAPGGQSGI

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
131

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
13363

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
11.35

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  response to stimulus
Process:  behavior
Process:  feeding behavior
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
Process:  neuropeptide signaling pathway
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF02072:Orexin

# Macromolecular_Interacting_Partner_8_Signals:
1-33

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
2897118

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
OREX_HUMAN (O43612)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
HCRT

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
HCRT

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:4847

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Endoplasmic reticulum; rough endoplasmic reticulum. Cytoplasmic vesicle (By similarity). Cell junction; synapse (By similarity). Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses (By similarity)

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>396 bp
ATGAACCTTCCTTCCACAAAGGTCTCCTGGGCCGCCGTGACGCTACTGCTGCTGCTGCTG
CTGCTGCCGCCCGCGCTGTTGTCGTCCGGGGCGGCTGCACAGCCCCTGCCCGACTGCTGT
CGTCAAAAGACTTGCTCTTGCCGCCTCTACGAGCTGCTGCACGGCGCGGGCAATCACGCG
GCCGGCATCCTCACGCTGGGCAAGCGGAGGTCCGGGCCCCCGGGCCTCCAGGGTCGGCTG
CAGCGCCTCCTGCAGGCCAGCGGCAACCACGCCGCGGGCATCCTGACCATGGGCCGCCGC
GCAGGCGCAGAGCCAGCGCCGCGCCCCTGCCTCGGGCGCCGCTGTTCCGCCCCGGCCGCC
GCCTCCGTCGCGCCCGGAGGACAGTCCGGGATCTGA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
AF041240

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_8_Locus:
17q21

# Macromolecular_Interacting_Partner_8_SNPs:
rs9902709; rs8072099; rs8072081; rs760282; rs41513044; rs4796777; rs34727363; rs3760391; rs748442; rs34801573; rs748443; rs28879196; rs28696012; rs12953110; rs35725938; rs748444; rs3760390; rs36046844; rs4796776; rs1453402; rs28863552; rs5820451; rs34171118; rs34640131; rs12450953; rs12603630; rs2293153; rs3744485; rs3785901; rs7226205; rs9896975; rs9905193

# Macromolecular_Interacting_Partner_8_General_References:
9491897; 10364220; 10583376; 11340621; 11283317; 10973318

# Macromolecular_Interacting_Partner_8_References:
17093123

# Macromolecular_Interacting_Partner_9_ID:
7916

# Macromolecular_Interacting_Partner_9_Name:
Interleukin-4 precursor

# Macromolecular_Interacting_Partner_9_Synonyms:
IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra

# Macromolecular_Interacting_Partner_9_Gene_Name:
IL4

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Interleukin4 precursor
MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAAS
KNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGL
NSCPVKEANQSTLENFLERLKTIMREKYSKCSS

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
17492

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
9.16

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  growth factor activity
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interleukin-4 receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00727:IL4

# Macromolecular_Interacting_Partner_9_Signals:
1-24

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
307061

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
IL4_HUMAN (P05112)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
IL4

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
IL4

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:6014

# Macromolecular_Interacting_Partner_9_PDB_ID:
1IAR

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>462 bp
ATGGGTCTCACCTCCCAACTGCTTCCCCCTCTGTTCTTCCTGCTAGCATGTGCCGGCAAC
TTTGTCCACGGACACAAGTGCGATATCACCTTACAGGAGATCATCAAAACTTTGAACAGC
CTCACAGAGCAGAAGACTCTGTGCACCGAGTTGACCGTAACAGACATCTTTGCTGCCTCC
AAGAACACAACTGAGAAGGAAACCTTCTGCAGGGCTGCGACTGTGCTCCGGCAGTTCTAC
AGCCACCATGAGAAGGACACTCGCTGCCTGGGTGCGACTGCACAGCAGTTCCACAGGCAC
AAGCAGCTGATCCGATTCCTGAAACGGCTCGACAGGAACCTCTGGGGCCTGGCGGGCTTG
AATTCCTGTCCTGTGAAGGAAGCCAACCAGAGTACGTTGGAAAACTTCTTGGAAAGGCTA
AAGACGATCATGAGAGAGAAATATTCAAAGTGTTCGAGCTGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
M13982

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_9_Locus:
5q31.1

# Macromolecular_Interacting_Partner_9_SNPs:
rs4986964; rs2243251; rs35648164; rs2070874; rs17772853; rs2227282; rs2227284; rs2243267; rs2243266; rs2243268; rs2243270; rs2243289; rs734244; rs2243258; rs2243253; rs9282745; rs2243290; rs2243274; rs2243288; rs2243261; rs2243279; rs2243252; rs2243276; rs2243259; rs2243285; rs2243269; rs2243277; rs2243260; rs2243255; rs2243283; rs2243281; rs2243263; rs2243264; rs2243286; rs2243256; rs2243275; rs9282746; rs2243284; rs2243282; rs2243250; rs2243248; rs2243247; rs2243246; rs2243249; rs4986963; rs2243238; rs2243243; rs10080170; rs2243242; rs2243245; rs2243307; rs2243240; rs2243244; rs2243257; rs35505814; rs2243262; rs2243308; rs2243271; rs2243272; rs34015525; rs2243280; rs2243278; rs34810562; rs12521281; rs9327637; rs2243309; rs2079102; rs35071211; rs6879348; rs10588641; rs28478089; rs7703922; rs9327636; rs11479198; rs34779821; rs3831509; rs35604055; rs41403547; rs2243287; rs2243265; rs2243273; rs35171620; rs4996002; rs41420944; rs34008602; rs2243241; rs10065221; rs34185442; rs10058157; rs34142320; rs35819063; rs2243239; rs34299499; rs2234648; rs2243306; rs11242122; rs11242123; rs1295682; rs2243202; rs2243204; rs2243205; rs2243206; rs2243207; rs2243208; rs2243209; rs2243210; rs2243211; rs2243212; rs2243213; rs2243217; rs2243218; rs2243219; rs2243220; rs2243222; rs2243225; rs2243226; rs2243231; rs2243232; rs2243235; rs2243291; rs2243292; rs2243298; rs2243299; rs2243300; rs2243301; rs2243302; rs2406539; rs36017530; rs4426908; rs743555

# Macromolecular_Interacting_Partner_9_General_References:
3016727; 2535858; 7806280; 3257560; 1993171; 1400355; 1511746; 10219247; 1932028; 1569578; 1567880; 1567881; 1609277; 1946344; 8151703; 7664036

# Macromolecular_Interacting_Partner_9_References:
16670768; 16707627

# Macromolecular_Interacting_Partner_10_ID:
8452

# Macromolecular_Interacting_Partner_10_Name:
Lymphotoxin-beta

# Macromolecular_Interacting_Partner_10_Synonyms:
LT-beta; Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3

# Macromolecular_Interacting_Partner_10_Gene_Name:
LTB

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Lymphotoxinbeta
MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD
PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS
DAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLE
GAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGA
VMVG

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
244

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
25390

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
5.02

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_10_Signals:
1-35

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
292279

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
TNFC_HUMAN (Q06643)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
LTB

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
LTB

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:6711

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>735 bp
ATGGGGGCACTGGGGCTGGAGGGCAGGGGTGGGAGGCTCCAGGGGAGGGGTTCCCTCCTG
CTAGCTGTGGCAGGAGCCACTTCTCTGGTGACCTTGTTGCTGGCGGTGCCTATCACTGTC
CTGGCTGTGCTGGCCTTAGTGCCCCAGGATCAGGGAGGACTGGTAACGGAGACGGCCGAC
CCCGGGGCACAGGCCCAGCAAGGACTGGGGTTTCAGAAGCTGCCAGAGGAGGAGCCAGAA
ACAGATCTCAGCCCCGGGCTCCCAGCTGCCCACCTCATAGGCGCTCCGCTGAAGGGGCAG
GGGCTAGGCTGGGAGACGACGAAGGAACAGGCGTTTCTGACGAGCGGGACGCAGTTCTCG
GACGCCGAGGGGCTGGCGCTCCCGCAGGACGGCCTCTATTACCTCTACTGTCTCGTCGGC
TACCGGGGCCGGGCGCCCCCTGGCGGCGGGGACCCCCAGGGCCGCTCGGTCACGCTGCGC
AGCTCTCTGTACCGGGCGGGGGGCGCCTACGGGCCGGGCACTCCCGAGCTGCTGCTCGAG
GGCGCCGAGACGGTGACTCCAGTGCTGGACCCGGCCAGGAGACAAGGGTACGGGCCTCTC
TGGTACACGAGCGTGGGGTTCGGCGGCCTGGTGCAGCTCCGGAGGGGCGAGAGGGTGTAC
GTCAACATCAGTCACCCCGATATGGTGGACTTCGCGAGAGGGAAGACCTTCTTTGGGGCC
GTGATGGTGGGGTGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
L11016

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_10_Locus:
6p21.3

# Macromolecular_Interacting_Partner_10_SNPs:
Not Available

# Macromolecular_Interacting_Partner_10_General_References:
7916655; 9299492; 10202016

# Macromolecular_Interacting_Partner_10_References:
16738813; 16832713; 16849509; 16885379

# Macromolecular_Interacting_Partner_11_ID:
8202

# Macromolecular_Interacting_Partner_11_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_11_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_11_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_11_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_11_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_11_Signals:
None

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_11_Locus:
10q22

# Macromolecular_Interacting_Partner_11_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_11_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_11_References:
16873415; 17053161

# Macromolecular_Interacting_Partner_12_ID:
7854

# Macromolecular_Interacting_Partner_12_Name:
Equilibrative nucleoside transporter 1

# Macromolecular_Interacting_Partner_12_Synonyms:
Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Equilibrative NBMPR-sensitive nucleoside transporter; Nucleoside transporter, es-type; Solute carrier family 29 member 1

# Macromolecular_Interacting_Partner_12_Gene_Name:
SLC29A1

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Equilibrative nucleoside transporter 1
MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDA
QASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAIL
LVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQ
GLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKL
EGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIF
TITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRW
LPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPK
KVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
456

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
50220

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
8.39

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs)

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_12_Signals:
1-24

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
1845345

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
S29A1_HUMAN (Q99808)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
SLC29A1

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
SLC29A1

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:11003

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>1371 bp
ATGACAACCAGTCACCAGCCTCAGGACAGATACAAAGCTGTCTGGCTTATCTTCTTCATG
CTGGGTCTGGGAACGCTGCTCCCGTGGAATTTTTTCATGACGGCCACTCAGTATTTCACA
AACCGCCTGGACATGTCCCAGAATGTGTCCTTGGTCACTGCTGAACTGAGCAAGGACGCC
CAGGCGTCAGCCGCCCCTGCAGCACCCTTGCCTGAGCGGAACTCTCTCAGTGCCATCTTC
AACAATGTCATGACCCTATGTGCCATGCTGCCCCTGCTGTTATTCACCTACCTCAACTCC
TTCCTGCATCAGAGGATCCCCCAGTCCGTACGGATCCTGGGCAGCCTGGTGGCCATCCTG
CTGGTGTTTCTGATCACTGCCATCCTGGTGAAGGTGCAGCTGGATGCTCTGCCCTTCTTT
GTCATCACCATGATCAAGATCGTGCTCATTAATTCATTTGGTGCCATCCTGCAGGGCAGC
CTGTTTGGTCTGGCTGGCCTTCTGCCTGCCAGCTACACGGCCCCCATCATGAGTGGCCAG
GGCCTAGCAGGCTTCTTTGCCTCCGTGGCCATGATCTGCGCTATTGCCAGTGGCTCGGAA
CTATCAGAAAGTGCCTTCGGCTACTTTATCACAGCCTGTGCTGTTATCATTTTGACCATC
ATCTGTTACCTGGGCCTGCCCCGCCTGGAATTCTACCGCTACTACCAGCAGCTCAAGCTT
GAAGGACCCGGGGAGCAGGAGACCAAGTTGGACCTCATTAGCAAAGGAGAGGAGCCAAGA
GCAGGCAAAGAGGAATCTGGAGTTTCAGTCTCCAACTCTCAGCCCACCAATGAAAGCCAC
TCTATCAAAGCCATCCTGAAAAATATCTCAGTCCTGGCTTTCTCTGTCTGCTTCATCTTC
ACTATCACCATTGGGATGTTTCCAGCCGTGACTGTTGAGGTCAAGTCCAGCATCGCAGGC
AGCAGCACCTGGGAACGTTACTTCATTCCTGTGTCCTGTTTCTTGACTTTCAATATCTTT
GACTGGTTGGGCCGGAGCCTCACAGCTGTATTCATGTGGCCTGGGAAGGACAGCCGCTGG
CTGCCAAGCCTGGTGCTGGCCCGGCTGGTGTTTGTGCCACTGCTGCTGCTGTGCAACATT
AAGCCCCGCCGCTACCTGACTGTGGTCTTCGAGCACGATGCCTGGTTCATCTTCTTCATG
GCTGCCTTTGCCTTCTCCAACGGCTACCTCGCCAGCCTCTGCATGTGCTTCGGGCCCAAG
AAAGTGAAGCCAGCTGAGGCAGAGACCGCAGGAGCCATCATGGCCTTCTTCCTGTGTCTG
GGTCTGGCACTGGGGGCTGTTTTCTCCTTCCTGTTCCGGGCAATTGTGTGA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
U81375

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_12_Locus:
6p21.2-p21.1

# Macromolecular_Interacting_Partner_12_SNPs:
Not Available

# Macromolecular_Interacting_Partner_12_General_References:
8986748; 10755314; 12384580

# Macromolecular_Interacting_Partner_12_References:
16688763; 16824629

# Macromolecular_Interacting_Partner_13_ID:
8758

# Macromolecular_Interacting_Partner_13_Name:
Equilibrative nucleoside transporter 2

# Macromolecular_Interacting_Partner_13_Synonyms:
Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter; Equilibrative NBMPR-insensitive nucleoside transporter; Nucleoside transporter, ei-type; Solute carrier family 29 member 2; 36 kDa nucleolar protein HNP36; Hydrophobic nucleolar protein, 36 kDa; Delayed-early response protein 12

# Macromolecular_Interacting_Partner_13_Gene_Name:
SLC29A2

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Equilibrative nucleoside transporter 2
MARGDAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGNSTARILSTNHTG
PEDAFNFNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGSLLAILLLFALTAALVKVD
MSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLL
SMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQELETKAE
LLQSDENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLV
FTVTLSVFPAITAMVTSSTSPGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRL
LPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPR
QVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
456

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
50114

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
6.02

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
 Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_13_Signals:
1-24

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
13-33
70-90
99-119
124-144
162-182
193-213
291-311
324-344
360-380
386-406
432-452

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
2811137

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
S29A2_HUMAN (Q14542)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
SLC29A2

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
SLC29A2

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:11004

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Isoform 1:Cell membrane; multi-pass membrane protein. Isoform 2:Nucleus; nuclear membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>1371 bp
ATGGCGCGAGGAGACGCCCCGCGGGACAGCTACCACCTGGTCGGGATCAGCTTCTTCATC
CTGGGGCTGGGCACCCTCCTTCCCTGGAACTTCTTCATCACCGCCATCCCGTACTTCCAG
GCGCGACTGGCCGGGGCCGGCAACAGCACAGCCAGGATCCTGAGCACCAACCACACGGGT
CCCGAGGATGCCTTCAACTTCAACAATTGGGTGACGCTGCTGTCCCAGCTGCCCCTGCTG
CTCTTCACCCTCCTCAACTCCTTCCTGTACCAGTGCGTCCCGGAGACGGTGCGCATTCTG
GGCAGCCTGCTGGCCATACTGCTGCTCTTTGCCCTGACAGCAGCGCTGGTCAAGGTGGAC
ATGAGCCCCGGACCCTTCTTCTCCATCACCATGGCCTCCGTCTGCTTCATCAACTCCTTC
AGTGCAGTCCTACAGGGCAGCCTCTTCGGGCAGCTGGGCACCATGCCCTCCACCTACAGC
ACCCTCTTCCTCAGCGGCCAGGGCCTGGCTGGGATCTTTGCTGCCCTTGCCATGCTCCTG
TCCATGGCCAGTGGCGTGGACGCCGAGACCTCTGCCCTGGGGTACTTTATCACGCCCTGT
GTGGGCATCCTCATGTCCATCGTGTGTTACCTGAGCCTGCCTCACCTGAAGTTTGCCCGC
TACTACCTGGCCAATAAATCATCCCAGGCCCAAGCTCAGGAGCTGGAGACCAAAGCTGAG
CTCCTCCAGTCTGATGAGAACGGGATTCCCAGTAGTCCCCAGAAAGTAGCTCTGACCCTG
GATCTTGACCTGGAGAAGGAGCCGGAATCAGAGCCAGATGAGCCCCAGAAGCCAGGAAAA
CCTTCAGTCTTCACTGTCTTCCAGAAGATCTGGCTGACAGCGCTGTGCCTTGTGTTGGTC
TTCACAGTCACCCTGTCCGTCTTCCCCGCCATCACAGCCATGGTGACCAGCTCCACCAGT
CCTGGGAAGTGGAGTCAGTTCTTCAACCCCATCTGCTGCTTCCTCCTCTTCAACATCATG
GACTGGCTGGGACGGAGCCTGACCTCTTACTTCCTGTGGCCAGACGAGGACAGCCGGCTG
CTGCCCCTGCTGGTCTGCCTGCGGTTCCTGTTCGTGCCCCTCTTCATGCTGTGCCACGTG
CCCCAGAGGTCCCGGCTGCCCATCCTCTTCCCACAGGATGCCTACTTCATCACCTTCATG
CTGCTCTTTGCCGTTTCTAATGGCTACCTGGTGTCCCTCACCATGTGCCTGGCGCCCAGG
CAGGTGCTGCCACACGAGAGGGAGGTGGCCGGCGCCCTCATGACCTTCTTCCTGGCCCTG
GGACTTTCCTGTGGAGCCTCCCTCTCCTTCCTCTTCAAGGCGCTGCTCTGA

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
AF034102

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_13_Locus:
11q13

# Macromolecular_Interacting_Partner_13_SNPs:
rs8187661; rs1039593; rs3177514; rs4930358; rs7126064; rs2292123; rs2279861; rs2279862; rs7125100; rs7126018; rs12416747; rs1039594; rs10791872; rs8187658; rs3867130; rs12576299; rs1344410; rs12576293; rs12577196; rs4930178; rs4930359; rs12281049; rs4244813; rs7107191; rs7104297; rs17850744; rs17855425; rs12801227; rs34186490; rs34124904; rs11227466; rs4554890; rs3741366; rs10605893; rs11403442; rs7111197; rs10632640; rs35639157; rs35962792; rs7946434; rs33943132; rs34029417; rs1815807; rs35659701; rs7103571; rs35791794; rs10648232; rs11423263; rs34482391; rs1566871; rs11298226; rs12800796; rs35509820; rs11461356; rs35457397; rs1201452; rs1210071; rs34585457; rs12360603; rs1047029; rs10791871; rs12794121; rs34272485; rs7130857; rs8187644; rs8187646; rs8187647; rs8187657; rs8187659; rs8187660

# Macromolecular_Interacting_Partner_13_General_References:
9478986; 9396714; 7639753

# Macromolecular_Interacting_Partner_13_References:
Not Available

# Macromolecular_Interacting_Partner_14_ID:
8857

# Macromolecular_Interacting_Partner_14_Name:
Equilibrative nucleoside transporter 3

# Macromolecular_Interacting_Partner_14_Synonyms:
Solute carrier family 29 member 3

# Macromolecular_Interacting_Partner_14_Gene_Name:
SLC29A3

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>Equilibrative nucleoside transporter 3
MAVVSEDDFQHSSNSTYRTTSSSLRADQEALLEKLLDRPPPGLQRPEDRFCGTYIIFFSL
GIGSLLPWNFFITAKEYWMFKLRNSSSPATGEDPEGSDILNYFESYLAVASTVPSMLCLV
ANFLLVNRVAVHIRVLASLTVILAIFMVITALVKVDTFSWTRGFFAVTIVCMVILSGAST
VFSSSIYGMTGSFPMRNSQALISGGAMGGTVSAVASLVDLAASSDVRNSALAFFLTATIF
LVLCMGLYLLLSRLEYARYYMRPVLAAHVFSGEEELPQDSLSAPSVASRFIDSHTPPLRP
ILKKTASLGFCVTYVFFITSLIYPAVCTNIESLNKGSGSLWTTKFFIPLTTFLLYNFADL
CGRQLTAWIQVPGPNSKALPGFVLLRTCLIPLFVLCNYQPRVHLKTVVFQSDVYPALLSS
LLGLSNGYLSTLALLYGPKIVPRELAEATGVVMSFYVCLGLTLGSACSTLLVHLI

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
475

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
51875

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
7.85

# Macromolecular_Interacting_Partner_14_GO_Classification:
>>>
 Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_14_General_Function:
Not Available

# Macromolecular_Interacting_Partner_14_Specific_Function:
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter)

# Macromolecular_Interacting_Partner_14_Pathway:
Not Available

# Macromolecular_Interacting_Partner_14_Reaction:
Not Available

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_14_Signals:
Not Available

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
50-72
107-126
131-153
163-185
198-220
230-252
308-330
340-357
378-395
415-437
450-472

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
12656639

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
S29A3_HUMAN (Q9BZD2)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
SLC29A3

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
SLC29A3

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:23096

# Macromolecular_Interacting_Partner_14_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>1428 bp
ATGGCCGTTGTCTCAGAGGACGACTTTCAGCACAGTTCAAACTCCACCTACAGAACCACA
AGCAGCAGTCTCCGAGCTGACCAGGAGGCACTGCTTGAGAAGCTGCTGGACCGCCCGCCC
CCTGGCCTGCAGAGGCCCGAGGACCGCTTCTGTGGCACATACATCATCTTCTTCAGCCTG
GGCATTGGCAGTCTACTGCCATGGAACTTCTTTATCACTGCCAAGGAGTACTGGATGTTC
AAACTCCGCAACTCCTCCAGCCCAGCCACCGGGGAGGACCCTGAGGGCTCAGACATCCTG
AACTACTTTGAGAGCTACCTTGCCGTTGCCTCCACCGTGCCCTCCATGCTGTGCCTGGTG
GCCAACTTCCTGCTTGTCAACAGGGTTGCAGTCCACATCCGTGTCCTGGCCTCACTGACG
GTCATCCTGGCCATCTTCATGGTGATAACTGCACTGGTGAAGGTGGACACTTTCTCCTGG
ACCCGTGGCTTTTTTGCGGTCACCATTGTCTGCATGGTGATCCTCAGCGGTGCCTCCACT
GTCTTCAGCAGCAGCATCTACGGCATGACCGGCTCCTTTCCTATGAGGAACTCCCAGGCA
CTGATATCAGGAGGAGCCATGGGCGGGACGGTCAGCGCCGTGGCCTCATTGGTGGACTTG
GCTGCATCCAGTGATGTGAGGAACAGCGCCCTGGCCTTCTTCCTGACGGCCACCATCTTC
CTCGTGCTCTGCATGGGACTCTACCTGCTGCTGTCCAGGCTGGAGTATGCCAGGTACTAC
ATGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGAAGAGGAGCTTCCCCAGGACTCC
CTCAGTGCCCCTTCGGTGGCCTCCAGATTCATTGATTCCCACACACCCCCTCTCCGCCCC
ATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGTCTTCTTCATCACCAGC
CTCATCTACCCCGCCGTCTGCACCAACATCGAGTCCCTCAACAAGGGCTCGGGCTCACTG
TGGACCACCAAGTTTTTCATCCCCCTCACTACCTTCCTCCTGTACAACTTTGCTGACCTA
TGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAATAGCAAGGCGCTCCCA
GGGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTTCGTGCTCTGTAACTACCAGCCC
CGCGTCCACCTGAAGACTGTGGTCTTCCAGTCCGATGTGTACCCCGCACTCCTCAGCTCC
CTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCTCTACGGGCCTAAGATT
GTGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGATGTCCTTTTATGTGTGCTTGGGC
TTAACACTGGGCTCAGCCTGCTCTACCCTCCTGGTGCACCTCATCTAG

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
AF326987

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_14_Locus:
10q22.1

# Macromolecular_Interacting_Partner_14_SNPs:
rs2487068; rs2252996; rs780668; rs2277257; rs999940; rs16928737; rs2252997; rs1084004; rs2275579; rs780680; rs780664; rs1538899; rs780660; rs780659; rs780666; rs703257; rs780654; rs946875; rs703256; rs2394793; rs7069807; rs1110399; rs780677; rs4600131; rs780675; rs2243460; rs780670; rs780676; rs6480510; rs2487067; rs6480511; rs809691; rs883764; rs7086724; rs12256138; rs2012500; rs780662; rs4494244; rs780672; rs780653; rs3781314; rs2249987; rs1538895; rs2066211; rs780655; rs10823723; rs1316421; rs11815656; rs3824770; rs7100381; rs2250002; rs6480513; rs12251921; rs12767108; rs16928705; rs10999773; rs10999778; rs1572810; rs7076329; rs6480514; rs780667; rs7090745; rs2249882; rs883763; rs780679; rs780674; rs7080325; rs3781316; rs2249989; rs780678; rs11812689; rs780669; rs2487066; rs2243496; rs7067629; rs10999776; rs7095417; rs11594628; rs780665; rs4430425; rs4348816; rs780661; rs3781311; rs3781313; rs2249753; rs10999770; rs7091983; rs884031; rs3781324; rs780658; rs10999775; rs7072838; rs780671; rs946973; rs10740374; rs12252326; rs3781310; rs10999771; rs3781309; rs3781312; rs1890885; rs2243540; rs3758570; rs3781317; rs2066209; rs780656; rs7900534; rs7083031; rs2066210; rs6480512; rs12220541; rs884681; rs3781327; rs16928722; rs7068179; rs7090777; rs12249513; rs10740375; rs7913673; rs780673; rs10999777; rs10999781; rs780657; rs7090611; rs884680; rs3781326; rs7086520; rs7071162; rs7071738; rs2249752; rs12252139; rs17525188; rs12252279; rs2243485; rs7071979; rs10999772; rs3781325; rs7087714; rs7084342; rs4747148; rs7924115; rs946979; rs780681; rs1572812; rs35065420; rs6650127; rs34069552; rs10716665; rs35206666; rs12263170; rs10625840; rs34905233; rs11376986; rs35919163; rs5786035; rs34110374; rs12356731; rs35335105; rs12269478; rs12243734; rs34152212; rs7913062; rs3059614; rs12762394; rs7911708; rs7914132; rs4746081; rs7094989; rs35701283; rs12267767; rs12220170; rs7068296; rs34294547; rs35368644; rs41281300; rs3781318; rs4641383; rs7916422; rs34315182; rs10999774; rs35720104; rs10999769; rs35239123; rs7077024; rs3837344; rs7913610; rs10552605; rs10999779; rs780663; rs35509882; rs3893272; rs3059612; rs35156362; rs1609652; rs35485497; rs34058912; rs12243650; rs4147262; rs7903407; rs35942216; rs12763826; rs3837345; rs34297699; rs34965758; rs3824768; rs34491538; rs41300554; rs36074226; rs7095479; rs7067937; rs11296364; rs35855172; rs7897272; rs34640546; rs3781315; rs34395748; rs12355187; rs12261581; rs10686987; rs12779065; rs10999783; rs36087675; rs12762772; rs5786034; rs10999782; rs34650529; rs34632350; rs10553895; rs34721394; rs12249991; rs11593088; rs3059610; rs28708771; rs35956296; rs10999768; rs28688626; rs35685893; rs10823722; rs10999766; rs10999784; rs10999785; rs10999786; rs10999788; rs11595617; rs11816935; rs12098507; rs12254223; rs12412201; rs12414898; rs1538898; rs1609651; rs17546494; rs2185416; rs2248674; rs34217506; rs35016944; rs35685474; rs7079524; rs780682; rs780683; rs780687; rs780688; rs780689; rs780690; rs780692; rs780693; rs780694; rs780695; rs780697; rs780698; rs7895122; rs7899555; rs869545; rs946879

# Macromolecular_Interacting_Partner_14_General_References:
11396612; 12384580; 12975309

# Macromolecular_Interacting_Partner_14_References:
Not Available

End of HMDB00050

Beginning of HMDB00051
# Accession_No:
HMDB00051

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-25 16:25:35

# biospider_lastupdate:
2007-07-25 09:17:15

# Common_Name:
Ammonia

# Description:
Ammonia is a colorless alkaline gas with a characteristic pungent smell; it is lighter than air, (density =0.589). It is easily liquefied and the liquid boils at -33.7 degree centigrade , and solidifies at -75 degree  centigrade to a mass of white crystals.  Ammonia is an important source of nitrogen for living systems.  Ammonia is formed in the body during decomposition of organic materials during a large number of metabolically important reactions.  Ammonia also plays a role in both normal and abnormal animal physiology. Ammonia is created through normal amino acid metabolism and is toxic in high concentrations. The liver converts ammonia to urea through a series of reactions known as the urea cycle. Liver dysfunction, such as that seen in cirrhosis, may lead to elevated amounts of ammonia in the blood (hyperammonemia).

# Synonyms:
Amine; Ammoniaca [italian]; Am-fol; Tertiaeres amin; Amino group; Tertiary amine; Liquid ammonia; Nitro-sil; Amoniak [polish]; NA; Terminal amide; NH; Nitrogen radical; Ammonia inhalant; Ammoniak [german]; Ammonia solution strong (NF); Ammonia gas; Ammonium bromide-81Br; Anhydrous ammonia;  Primary amines; Ammonia anhydrous; Ammonia (conc 20% or greater); Aromatic ammonia vaporole; Ammoniacum gummi; Primaeres amin; Ammonium ion; Sekundaeres amin; Secondary amines;  Ammoniak; Ammoniakgas; E Remark 999; Primary amine; Nitrogen atom; Ammonia solution; R-NH2; Primary monoamine; Ammonia water; Azane; Secondary amine; Ammonia solution strong [usan]; Spirit of hartshorn; Ammonia water (JP15); Ammoniac [french]; Ammoniak kconzentrierter; R2NH; Ammonia

# Chemical_IUPAC_Name:
ammonia

# Chemical_Formula:
NH3

# Chemical_Structure:
tbl_chemical:::HMDB00051_ZOOM.png:::119283156339788613

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00051_THUMB.png:::119283156166962311

# Taxonomy_Kingdom:
Inorganic

# Taxonomy_Class:
Nitrogenous Compounds

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
Not Available

# Taxonomy_Biofunction:
Component of Alanine and aspartate metabolism; Component of Aminosugars metabolism; Component of Arginine and proline metabolism; Component of beta-Alanine metabolism; Component of Cysteine metabolism; Component of D-Arginine and D-ornithine metabolism; Component of D-Glutamine and D-glutamate metabolism; Component of Glutamate metabolism; Component of Glycine, serine and threonine metabolism; Component of Histidine metabolism; Component of Methionine metabolism; Component of Nitrogen metabolism; Component of Peptidoglycan biosynthesis; Component of Phenylalanine metabolism; Component of Purine metabolism; Component of Pyrimidine metabolism; Component of Selenoamino acid metabolism; Component of Tryptophan metabolism; Component of Tyrosine metabolism; Component of Vitamin B6 metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
17.02655

# Molecular_Weight_Avg:
17.03052

# Smiles_String_isomeric:
N

# Smiles_String_canonical:
N

# KEGG_Compound_ID:
C00014

# BioCyc_ID:
AMMONIA

# PubChem_CID:
222

# PubChem_SID:
8014513; 594654; 24857750; 24873257; 8029108; 17422787; 10535283; 10317926; 17422543; 11538887; 24868666; 8012124; 17436446; 8017037; 8029533; 8020772; 8011146; 8010373; 24865474; 8027842; 3316; 8007867; 8007223; 8009405; 8028893; 8026010; 8026008; 8024133; 8018273; 10317931; 5257791; 8013167; 22394623; 8019657; 8020837; 8007773; 8026161; 14710328; 8150513; 8007244; 166832; 17397073; 8006866; 8021081; 24860942; 8028993; 8027841; 10323059; 8017829; 8029098; 23944516; 8007154; 8012764; 8021613; 8022912; 8010125; 14716551; 8017842; 24875167; 24902263; 24770310; 8029099; 8145302; 8007587; 8021080; 8145696; 15119548; 10318863; 8021176; 10318864; 14716925; 8011144; 8011141; 8010494; 8007247; 24770816; 8007249; 8021173; 10317925; 24770315; 24864477; 8017435; 8009335; 8013207; 24697563; 10511053; 17403736; 8019079; 8023899; 8026465; 24864476; 8029392; 8007409; 10317924; 10317928; 8013400; 8028825; 8007239; 8027987; 22394625; 8008747

# OMIM_ID:
102770; 237310; 238700; 238970

# Metagene_ID:
CARNITINE TRANSPORTER DEFECT. PRIMARY SYSTEMIC CARNITINE DEFICIENCY: 90; PATENT DUCTUS VENOSUS: 460; VALPROATE THERAPY: ANTICONVULASANT HYPERSENSITIVITY SYNDROME VALPROATE ASSOCIATED HEPATOTOXICITY: 324; PROPIONIC ACIDEMIA. KETOTIC HYPERGLYCINEMIA (PA): 18; 3-METHYLGLUTACONIC ACIDURIA (TYPE IV): 338; LIVER DISEASE, LIVER FAILURE, UNSPECIFIC: 264; ARGININOSUCCINIC ACIDURIA (ASL): 25; 3-METHYL-CROTONYL-GLYCINURIA: 27; PYRUVATE DEHYDROGENASE DEFICIENCY (E3): 333; SHORT CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD): 40; HYPERDIBASIC AMINOACIDURIA II. LYSINURIC PROTEIN INTOLERANCE: 61; METHYLMALONIC ACIDURIA, cblB TYPE: 517; REYE SYNDROME LIKE MANIFESTATIONS: 303; REYE SYNDROME: 268; CITRULLINEMIA TYPE I. ASS: 92; N-ACETYLGLUTAMATE SYNTHETASE DEFICIENCY. NAGS DEFICIENCY: 243; PYRUVATE CARBOXYLASE DEFICIENCY: 109; LONG-CHAIN-3-HYDROXYACYL-CoA DEHYDROGENASE DEFICIENCY (LCHAD): 308; HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]: 215; ISOVALERIC ACIDEMIA: 10; FUMARIC ACIDURIA: 31; ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC): 189; METHYLMALONIC ACIDURIA, cblA TYPE: 328; CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY: 342; CARNITINE DEFICIENCY, MYOPATHIC: 282; CARNITINE PALMITOYL TRANSFERASE DEFICIENCY (I): 263; MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM: 79; CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY (CPS): 77; DELTA-PYRROLIDINE-5-CARBOXYLATE SYNTHASE DEFICIENCY: 474; MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD): 39; CARNITINE PALMITOYL TRANSFERASE DEFICIENCY (II): 94; GLUTARIC ACIDURIA II: 9; METHYLMALONIC ACIDURIA (MMA): 15; CITRULLINEMIA TYPE II, ADULT-ONSET: 448; ARGININEMIA. HYPERARGININEMIA, ARGINASE DEFICIENCY: 60; 3-HYDROXY-3-METHYLGLUTARYL-CoA LYASE DEFICIENCY: 4; PYRUVATE DEHYDROGENASE DEFICIENCY (E2): 431; BIOTINIDASE DEFICIENCY: 73; ACRODERMATITIS ENTEROHEPATHICA: 411; HYPERINSULINISM-HYPERAMMONEMIA SYNDROME: 459; GLUTATHIONE SYNTHETASE DEFICIENCY: 19; BETA-KETOTHIOLASE DEFICIENCY: 5

# BiGG_ID:
Not Available

# Wikipedia_ID:
Ammonia

# METLIN_ID:
3189

# Ref_ID:
11779097; 10327416; 12445521; 12881593; 8579834; 11754523; 11842946; 15783019; 15611036; 10803116; 11388600; 12020613; 15058165; 10958815; 12553956; 10587497; 15005636; 10370701; 10356662; 10395620

# ChEBI_ID:
16134

# CAS_Registry_Number:
7664-41-7

# InChI:
InChI=1/H3N/h1H3

# Synthesis_Reference:
Not Available

# Melting_Point:
-77.7 oC

# Melting_Point_predicted:
13.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
482 mg/mL at 24 oC [DEAN,JA (1985)]

# H2O_Solubility_Predicted:
Not Available

# phys_charge:
0

# State:
Liquid

# LogP:
Not Available

# LogP_predicted:
0.23 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00051.pdf:::118537663644941172

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Ammonia.mol:::1132723803656136971

# SDF_File_[Text]:
tbl_chemical:::HMDB00051.sdf:::11928315590284364

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00051.pdb:::119283156033355981

# PDB_ID:
1D2U

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1D2U.txt:::1132720900312495045

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Ammonia.gif:::1132732102796550646

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00051_peaks.txt:::1156309511137847597

# Predicted_C_NMR_Spectrum:
Not Available

# pred_cnmr_peaklist:
Not Available

# Mass_Spectrum:
tbl_chemical:::HMDB00051.jpg:::1132798875875697869

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Bile; Blood; CSF; Cellular Cytoplasm; Feces; Saliva; Sweat; Urine

# Concentration_[Normal]:
Urine	1900.0 +/- 350.0	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	11842946
Urine	2330.0 (724.0-3950.0)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Blood	27.5 +/- 3.6	N/A	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	29.0 (10.0-47.0)	umol/L	Adult:>18_yrs_old	Both	Normal	Merck Manual
Blood	29.0 (13.0 - 46.0)	umol/L	Adult:>18_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 91. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	35.0 (20.0 - 58.0)	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 91. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	29.0 (17.0 - 51.0)	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 91. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	50.4 +/- 17.0	uM	Adult:>18_yrs_old	Both	Normal	12553956
Cerebrospinal_Fluid(CSF)	11.9	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cellular_Cytoplasm	800 (700-900)	umol/L	Adult:>18_yrs_old	Both	Normal	8579834


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
3-Hydroxy-3-Methylglutaric Acidemia; 3-Methyl-Crotonyl-Glycinuria; 3-Methylglutaconic Aciduria (Type IV); Acrodermatitis Enterohepathica; Adenosylcobalamin Deficiency (CBLA, CBLB); Anticonvulasant Hypersensitivity Syndrome Valproate Associated Hepatotoxicity (in valproate therapy); Argininemia, Hyperargininemia, Arginase Deficiency; Argininosuccinic Aciduria (ASL); Beta-Ketothiolase Deficiency; Biotinidase Deficiency; Carbamoyl Phosphate Synthetase Deficiency (CPS); Carnitine Deficiency, Myopathic; Carnitine Palmitoyl Transferase Deficiency (I); Carnitine Palmitoyl Transferase Deficiency (II); Carnitine-Acylcarnitine Translocase Deficiency; Citrullinemia Type I; Citrullinemia Type II, Adult-Onset; Delta-Pyrrolidine-5-Carboxylate Synthase Deficiency; Fumaric Aciduria; Gastritis; Glutaric Aciduria II; Glutathione Synthetase Deficiency; Hepatic Encephalopathy; Hyperdibasic Aminoaciduria II, Lysinuric Protein Intolerance; Hyperinsulinism-Hyperammonemia Syndrome; Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH-Syndrome); Hypopituitarism; Isovaleric Acidemia; Liver Disease, Liver Failure, Unspecific; Long-Chain-3-Hydroxyacyl-Coa Dehydrogenase Deficiency (LCHAD); Medium Chain Acyl-Coa Dehydrogenase Deficiency (MCAD); Methylmalonic Aciduria (MMA); Multiple Carboxylase Deficiency, Neonatal or Early Onset Form; N-Acetylglutamate Synthetase Deficiency (NAGS Deficiency); Ornithine Transcarbamylase Deficiency (OTC); Patent Ductus Venosus; Primary Systemic Carnitine Deficiency; Propionic Acidemia, Ketotic Hyperglycinemia (PA); Pyruvate Carboxylase Deficiency; Pyruvate Dehydrogenase Deficiency (E2); Pyruvate Dehydrogenase Deficiency (E3); Reye Syndrome; Reye Syndrome Like Manifestations; Short Chain Acyl-Coa Dehydrogenase Deficiency (SCAD)

# Pathway_Names:
Aminosugars metabolism;Type II secretion system;Purine metabolism;Vitamin B6 metabolism;Porphyrin and chlorophyll metabolism;Pantothenate and CoA biosynthesis;One carbon pool by folate;Glycolysis;Methionine metabolism;D-Arginine and D-ornithine metabolism;Alanine and aspartate metabolism

# Pathway_Images:
;Type II secretion system | map03090;Purine_Synthesis.jpg;;;;;Glycolysis.jpg;Methionine_Metabolism.jpg;;Aspartate_and_Alanine_metabolism.jpg

# KEGG_Images:
map00530;;map00230;map00750;map00860;map00770;map00670;map00010;map00271;map00472;map00252

# Pathway_Graphs:
;;Purine_Synthesis_Graph.jpg;;;;;Glycolysis_Graph.jpg;Methionine_Metabolism_Graph.jpg;;Aspartate_and_Alanine_metabolism_Graph.jpg

# Pathway_SBMLs:
;;Purine_Synthesis.xml;;;;;Glycolysis.xml;Methionine_Metabolism.xml;;Aspartate_and_Alanine_metabolism.xml

# Metabolic_Enzyme_1_ID:
5443

# Metabolic_Enzyme_1_Name:
Glucosamine-6-phosphate isomerase

# Metabolic_Enzyme_1_Synonyms:
Glucosamine-6- phosphate deaminase; GNPDA; GlcN6P deaminase; Oscillin

# Metabolic_Enzyme_1_Gene_Name:
GNPDA1

# Metabolic_Enzyme_1_Protein_Sequence:
>Glucosamine6phosphate isomerase
MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGD
LSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDA
FEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTK
VPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCD
EDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKEKETEKSQSSKKPYSD

# Metabolic_Enzyme_1_Number_of_Residues:
289

# Metabolic_Enzyme_1_Molecular_Weight:
32669

# Metabolic_Enzyme_1_Theoretical_pI:
6.91

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, interconverting aldoses and ketoses
Function:  glucosamine-6-phosphate deaminase activity
 ||
>>>
Process:  nitrogen compound metabolism
Process:  amine metabolism
Process:  amino sugar metabolism
Process:  glucosamine metabolism
Process:  N-acetylglucosamine metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3)

# Metabolic_Enzyme_1_Pathway:
map00530  Aminosugars metabolism

# Metabolic_Enzyme_1_Reaction:
D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + ammonia

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01182:Glucosamine_iso

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.5.99.6

# Metabolic_Enzyme_1_GenBank_ID_Protein:
2935438

# Metabolic_Enzyme_1_SwissProt_ID:
GNPI_HUMAN (P46926)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
GNPDA1

# Metabolic_Enzyme_1_Geneatlas_id:
GNPDA1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4417

# Metabolic_Enzyme_1_PDB_ID:
1NE7

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>870 bp
ATGAAGCTCATCATCCTGGAGCACTATTCTCAGGCGAGCGAGTGGGCGGCTAAATACATC
AGGAACCGTATCATCCAGTTTAACCCAGGGCCAGAGAAGTACTTCACCCTGGGGCTCCCC
ACTGGGAGTACCCCACTTGGCTGCTACAAGAAGCTGATTGAATACTATAAGAATGGGGAC
CTGTCCTTTAAATATGTGAAGACCTTCAACATGGATGAGTACGTGGGCCTTCCTCGAGAC
CACCCGGAGAGTTACCACTCCTTCATGTGGAACAACTTCTTCAAGCACATTGACATCCAC
CCAGAAAACACCCACATTCTGGATGGGAATGCAGTCGACCTACAGGCAGAATGTGATGCC
TTTGAAGAGAAGATCAAGGCTGCAGGTGGGATCGAGCTATTTGTTGGAGGCATCGGCCCT
GATGGACACATTGCCTTCAACGAGCCAGGCTCCAGTCTGGTGTCCAGGACCCGTGTGAAG
ACGCTGGCCATGGATACCATCCTGGCCAATGCTAGGTTCTTCGATGGAGAACTCACCAAG
GTGCCCACCATGGCCTTGACGGTGGGGGTGGGCACTGTCATGGATGCTAGAGAGGTGATG
ATCCTTATCACAGGTGCTCACAAGGCATTTGCTCTGTACAAGGCCATCGAGGAGGGAGTG
AACCACATGTGGACCGTGTCTGCCTTCCAGCAGCATCCCCGCACCGTGTTTGTGTGTGAC
GAGGATGCCACCTTGGAGCTGAAAGTGAAGACTGTCAAGTATTTCAAAGGTTTAATGCTT
GTTCATAACAAGTTGGTGGACCCCTTGTACAGTATCAAAGAGAAAGAAACTGAGAAAAGC
CAATCTTCGAAGAAACCATACAGCGATTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF048826

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_1_Locus:
5q21

# Metabolic_Enzyme_1_SNPs:
rs164080; rs7408; rs252120; rs2232193; rs252115; rs252111; rs252114; rs2232196; rs252112; rs1898679; rs252119; rs10214150; rs108593; rs351251; rs11746455; rs252118; rs252113; rs252117; rs7730740; rs252123; rs6887699; rs644639; rs252125; rs379285; rs252124; rs17524593; rs164501; rs644683; rs252122; rs428205; rs420547; rs11557800; rs2232198; rs1802147; rs1804084; rs2232192; rs11557799; rs4623179; rs35979770; rs449560; rs2232201; rs13175480; rs28672679; rs35914330; rs10628648; rs7708455; rs2232197; rs1134940; rs9986308; rs35408304; rs2232199; rs2232200; rs36114825; rs2232195; rs2232194; rs7733407; rs252094; rs189500; rs34467154; rs35952167; rs13187511; rs34537521; rs252116; rs41339846; rs3045628; rs35395011; rs426964; rs34709199; rs370150; rs12187204; rs11400936; rs6862017; rs6883498; rs13180040; rs164500; rs379553; rs33940540; rs12658433; rs10078983; rs153146; rs163920; rs164081; rs164498; rs164499; rs168331; rs252091; rs33992487; rs34476681; rs347525; rs366749; rs369592; rs379784; rs3910558; rs392582; rs403075; rs418921; rs439466; rs4912790; rs6580215; rs661944; rs665400

# Metabolic_Enzyme_1_General_References:
9438414; 7584044

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5802

# Metabolic_Enzyme_2_Name:
Cytidine deaminase

# Metabolic_Enzyme_2_Synonyms:
Cytidine aminohydrolase

# Metabolic_Enzyme_2_Gene_Name:
CDA

# Metabolic_Enzyme_2_Protein_Sequence:
>Cytidine deaminase
MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACY
PLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKP
DGTYIVMTVQELLPSSFGPEDLQKTQ

# Metabolic_Enzyme_2_Number_of_Residues:
146

# Metabolic_Enzyme_2_Molecular_Weight:
16185

# Metabolic_Enzyme_2_Theoretical_pI:
6.95

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  cytidine deaminase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleoside metabolism
Process:  pyrimidine nucleoside metabolism
Process:  pyrimidine ribonucleoside metabolism
Process:  cytidine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis

# Metabolic_Enzyme_2_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_2_Reaction:
cytidine + H2O = uridine + ammonia

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00383:dCMP_cyt_deam_1

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.5.4.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
598149

# Metabolic_Enzyme_2_SwissProt_ID:
CDD_HUMAN (P32320)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
CDA

# Metabolic_Enzyme_2_Geneatlas_id:
CDA

# Metabolic_Enzyme_2_hgnc_id:
HGNC:1712

# Metabolic_Enzyme_2_PDB_ID:
1MQ0

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_2_Gene_Sequence:
>441 bp
ATGGCCCAGAAGCGTCCTGCCTGCACCCTGAAGCCTGAGTGTGTCCAGCAGCTGCTGGTT
TGCTCCCAGGAGGCCAAGAAGTCAGCCTACTGCCCCTACAGTCACTTTCCTGTGGGGGCT
GCCCTGCTCACCCAGGAGGGGAGAATCTTCAAAGGGTGCAACATAGAAAATGCCTGCTAC
CCGCTGGGCATCTGTGCTGAACGGACCGCTATCCAGAAGGCCGTCTCAGAAGGGTACAAG
GATTTCAGGGCAATTGCTATCGCCAGTGACATGCAAGATGATTTTATCTCTCCATGTGGG
GCCTGCAGGCAAGTCATGAGAGAGTTTGGCACCAACTGGCCCGTGTACATGACCAAGCCG
GATGGTACGTATATTGTCATGACGGTCCAGGAGCTGCTGCCCTCCTCCTTTGGGCCTGAG
GACCTGCAGAAGACTCAGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
L27943

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_2_Locus:
1p36.2-p35

# Metabolic_Enzyme_2_SNPs:
rs2072671; rs1048977; rs602950; rs1781459; rs818194; rs12402391; rs818199; rs818196; rs558946; rs580032; rs818207; rs1689924; rs10916824; rs3738130; rs527912; rs10799647; rs577042; rs10916829; rs12404655; rs818193; rs498617; rs1253920; rs572529; rs818192; rs818197; rs477155; rs589942; rs12036993; rs517483; rs10916828; rs818198; rs11579252; rs471760; rs2985316; rs7523472; rs4655226; rs6659399; rs10916825; rs7548190; rs11579101; rs12407778; rs7534998; rs11578210; rs1781461; rs12068596; rs12119998; rs11583986; rs7535303; rs10799648; rs7523547; rs10916826; rs563329; rs12406106; rs11580375; rs818200; rs12072405; rs12120002; rs7523557; rs11801036; rs588485; rs7535200; rs7513317; rs1253921; rs7537463; rs488991; rs617782; rs10916827; rs7515668; rs500534; rs557219; rs818201; rs526987; rs10916830; rs12127536; rs506586; rs7537761; rs12072407; rs2320237; rs11582454; rs12401770; rs546692; rs11580377; rs542038; rs12072411; rs10916831; rs7545140; rs472629; rs573337; rs818202; rs1253904; rs532545; rs6690069; rs10916832; rs10916833; rs10916822; rs552722; rs603412; rs17854868; rs35163879; rs3215400; rs528031; rs1048980; rs34306899; rs602946; rs35247557; rs5772909; rs35125816; rs35859441; rs36002777; rs12131589; rs34293111; rs35045423; rs36106578; rs34634228; rs35916142; rs12123808; rs12145503; rs34652519; rs12029060; rs11584381; rs35668998; rs7414028; rs35869652; rs11589869; rs9970283; rs28646077; rs35735696; rs12030776; rs12036909; rs35182793; rs12141867; rs12075735; rs12722974; rs1253482; rs12022958; rs34008190; rs10628782; rs12737642; rs6676236; rs34347193; rs12072318; rs12059454; rs12119997; rs12125531; rs12401583; rs1152993; rs35187698; rs4655228; rs34809737; rs6679821; rs35806956; rs12039573; rs34822300; rs1253481; rs12024909; rs6657978; rs11272233; rs11579996; rs35088359; rs34840123; rs34904959; rs818206; rs12120392; rs35234793; rs34988653; rs6688783; rs41467355; rs12740823; rs11591189; rs9970233; rs6665553; rs35285740; rs1689925; rs34995697; rs12143372; rs28591485; rs34722632; rs11334996; rs3072072; rs9970226; rs12029033; rs35351279; rs12731069; rs11580211; rs28743049; rs12752560; rs692943; rs12123445; rs12135846; rs34901070; rs35637551; rs35770611; rs34861922; rs5772908; rs34862360; rs7531198; rs12092374; rs4259612; rs1689926; rs12744559; rs12737656; rs34715988; rs4655227; rs34918162; rs34185271; rs12045976; rs10916823; rs12240109; rs12726436; rs476790; rs12117048; rs33942385; rs10601038; rs12095662; rs10711308; rs12128671; rs10753504; rs10916836; rs10916837; rs1572487; rs1614627; rs1689916; rs1781457; rs485716; rs485833; rs540282; rs586422; rs650264; rs652536; rs6687370; rs6695655; rs678980; rs680748

# Metabolic_Enzyme_2_General_References:
7923172; 9878810; 9596658; 8422236

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5938

# Metabolic_Enzyme_3_Name:
Protein-glutamine gamma-glutamyltransferase E precursor

# Metabolic_Enzyme_3_Synonyms:
TGase E; TGE; TG(E; Transglutaminase-3[Contains: Protein- glutamine gamma-glutamyltransferase E 50 kDa non-catalytic chain; Protein-glutamine gamma-glutamyltransferase E 27 kDa catalytic chain]

# Metabolic_Enzyme_3_Gene_Name:
TGM3

# Metabolic_Enzyme_3_Protein_Sequence:
>Proteinglutamine gammaglutamyltransferase E precursor
MAALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGSNERLEFIVST
GPYPSESAMTKAVFPLSNGSSGGWSAVLQASNGNTLTISISSPASAPIGRYTMALQIFSQ
GGISSVKLGTFILLFNPWLNVDSVFMGNHAEREEYVQEDAGIIFVGSTNRIGMIGWNFGQ
FEEDILSICLSILDRSLNFRRDAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNWSGT
YTGGRDPRSWNGSVEILKNWKKSGFSPVRYGQCWVFAGTLNTALRSLGIPSRVITNFNSA
HDTDRNLSVDVYYDPMGNPLDKGSDSVWNFHVWNEGWFVRSDLGPSYGGWQVLDATPQER
SQGVFQCGPASVIGVREGDVQLNFDMPFIFAEVNADRITWLYDNTTGKQWKNSVNSHTIG
RYISTKAVGSNARMDVTDKYKYPEGSDQERQVFQKALGKLKPNTPFAATSSMGLETEEQE
PSIIGKLKVAGMLAVGKEVNLVLLLKNLSRDTKTVTVNMTAWTIIYNGTLVHEVWKDSAT
MSLDPEEEAEHPIKISYAQYEKYLKSDNMIRITAVCKVPDESEVVVERDIILDNPTLTLE
VLNEARVRKPVNVQMLFSNPLDEPVRDCVLMVEGSGLLLGNLKIDVPTLGPKEGSRVRFD
ILPSRSGTKQLLADFSCNKFPAIKAMLSIDVAE

# Metabolic_Enzyme_3_Number_of_Residues:
693

# Metabolic_Enzyme_3_Molecular_Weight:
76633

# Metabolic_Enzyme_3_Theoretical_pI:
5.60

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  peptide cross-linking
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. It is responsible for the later stages of cell envelope formation in the epidermis and the hair follicle

# Metabolic_Enzyme_3_Pathway:
Not Available

# Metabolic_Enzyme_3_Reaction:
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00927:Transglut_C;
PF01841:Transglut_core;
PF00868:Transglut_N

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.3.2.13

# Metabolic_Enzyme_3_GenBank_ID_Protein:
307504

# Metabolic_Enzyme_3_SwissProt_ID:
TGM3_HUMAN (Q08188)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
TGM3

# Metabolic_Enzyme_3_Geneatlas_id:
TGM3

# Metabolic_Enzyme_3_hgnc_id:
HGNC:11779

# Metabolic_Enzyme_3_PDB_ID:
1SGX

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>2082 bp
ATGGCTGCTCTAGGAGTCCAGAGTATCAACTGGCAGAAGGCCTTCAACCGACAAGCGCAT
CACACAGACAAGTTCTCCAGCCAGGAGCTCATCTTGCGGAGAGGCCAAAACTTCCAGGTC
TTAATGATCATGAACAAAGGCCTTGGCTCTAACGAAAGACTGGAGTTCATTGACACCACA
GGGCCTTACCCCTCAGAGTCGGCCATGACGAAGGCTGTGTTTCCACTCTCCAATGGCAGT
AGTGGTGGCTGGAGTGCGGTGCTTCAGGCCAGCAATGGCAATACTCTGACTATCAGCATC
TCCAGTCCTGCCAGCGCACCCATAGGACGGTACACAATGGCCCTCCAGATCTTCTCCCAG
GGCGGCATCTCCTCTGTGAAACTTGGGACGTTCATACTGCTTTTTAACCCCTGGCTGAAT
GTGGATAGCGTCTTTATGGGTAACCATGCTGAGAGAGAAGAGTATGTTCAGGAAGATGCC
GGCATCATCTTTGTGGGAAGCACAAACCGAATTGGCATGATTGGCTGGAACTTTGGACAG
TTTGAAGAAGACATTCTCAGCATCTGCCTCTCAATCTTGGATAGGAGTCTGAATTTCCGC
CGTGACGCTGCTACTGATGTGGCCAGCAGAAATGACCCCAAATACGTTGGCCGGGTGCTG
AGTGCCATGATCAATAGCAATGATGACAATGGTGTGCTTGCTGGGAATTGGAGCGGCACT
TACACCGGTGGCCGGGACCCAAGGAGCTGGGACGGCAGCGTGGAGATCCTCAAAAATTGG
AAAAAATCTGGCTTCAGCCCAGTCCGATATGGCCAGTGCTGGGTCTTTGCTGGGACCCTC
AACACAGCGCTGCGGTCTTTGGGGATTCCTTCCCGGGTGATCACCAACTTCAACTCAGCT
CATGACACAGACCGAAATCTCAGTGTGGATGTGTACTACGACCCCATGGGAAACCCCCTG
GACAAGGGTAGTGATAGCGTATGGAATTTCCATGTCTGGAATGAAGGCTGGTTTGTGAGG
TCTGACCTGGGCCCCCCGTACGGTGGATGGCAGGTGTTGGATGCTACCCCGCAGGAAAGA
AGCCAAGGGGTGTTCCAGTGCGGCCCCGCTTCGGTCATTGGTGTTCGAGAGGGTGATGTG
CAGCTGAACTTCGACATGCCCTTTATCTTCGCGGAGGTTAATGCCGACCGCATCACCTGG
CTGTACGACAACACCACTGGCAAACAGTGGAAGAATTCCGTGAACAGTCACACCATTGGC
AGGTACATCAGCACCAAGGCGGTGGGCAGCAATGCTCGCATGGACGTCACGGACAAGTAC
AAGTACCCAGAAGGCTCTGACCAGGAAAGACAAGTGTTCCAAAAGGCTTTGGGGAAACTT
AAACCCAACACGCCATTTGCCGCGACGTCTTCGATGGGTTTGGAAACAGAGGAACAGGAG
CCCAGCATCATCGGGAAGCTGAAGGTCGCTGGCATGCTGGCAGTAGGCAAAGAAGTCAAC
CTGGTCCTACTGCTCAAAAACCTGAGCAGGGATACGAAGACAGTGACAGTGAACATGACA
GCCTGGACCATCATCTACAACGGCACGCTTGTACATGAAGTGTGGAAGGACTCTGCCACA
ATGTCCCTGGACCCTGAGGAAGAGGCAGAACATCCCATAAAGATCTCGTACGCTCAGTAT
GAGAGGTACCTGAAGTCAGACAACATGATCCGGATCACAGCGGTGTGCAAGGTCCCAGAT
GAGTCTGAGGTGGTGGTGGAGCGGGACATCATCCTGGACAACCCCACCTTGACCCTGGAG
GTGCTGAACGAGGCTCGTGTGCGGAAGCCTGTGAACGTGCAGATGCTCTTCTCCAATCCA
CTGGATGAGCCGGTGAGGGACTGCGTGCTGATGGTGGAGGGAAGCGGCCTGCTGTTGGGT
AACCTGAAGATCGACGTGCCGACCCTAGGGCCCAAGGAGCGGTCCCGGGTCCGTTTTGAT
ATCCTGCCCTCCCGGAGTGGCACCAAGCAACTGCTCGCCGACTTCTCCTGCAACAAGTTC
CCTGCAATCAAGGCCATGTTGTCCATCGACGTAGCCGAATGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
L10386

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_3_Locus:
20q11.2

# Metabolic_Enzyme_3_SNPs:
rs214803; rs214814; rs6048066; rs214830; rs34234428; rs2228355; rs214831; rs214832; rs2013961; rs2422693; rs214819; rs214827; rs214806; rs1923099; rs1923101; rs214807; rs2076408; rs214776; rs3895160; rs214772; rs6036081; rs6048208; rs6106526; rs214764; rs214781; rs214774; rs214775; rs214818; rs6075897; rs2422687; rs214768; rs6048041; rs214766; rs6113720; rs214798; rs214763; rs6075916; rs214811; rs6132532; rs84825; rs2019155; rs214773; rs214812; rs6048154; rs214762; rs214828; rs214769; rs6106524; rs1012621; rs214783; rs16983952; rs11908614; rs214809; rs214793; rs214780; rs214804; rs214815; rs2014017; rs6417528; rs6048207; rs6048187; rs2014045; rs214765; rs214770; rs2012787; rs214784; rs6036162; rs11904869; rs214796; rs214799; rs2422690; rs11906667; rs1853092; rs214771; rs214801; rs2076406; rs214810; rs214786; rs6048053; rs214791; rs84823; rs6036147; rs214805; rs10485599; rs214782; rs214785; rs214817; rs214795; rs214792; rs6048188; rs11908571; rs6048070; rs2422691; rs2422692; rs7274152; rs214790; rs2076407; rs6048195; rs3865535; rs11907047; rs2076403; rs6137670; rs2422689; rs214794; rs7262933; rs6137695; rs11904909; rs214829; rs7263873; rs214823; rs6113756; rs6137668; rs6137716; rs84824; rs214797; rs4097062; rs8119589; rs6082720; rs6048122; rs6113688; rs2019184; rs2092378; rs214800; rs6036087; rs2013952; rs7353254; rs3838045; rs6137717; rs214824; rs214788; rs6036076; rs214813; rs6082659; rs6113687; rs8123507; rs3855686; rs1923100; rs11907640; rs6048182; rs214778; rs2019129; rs214789; rs6515233; rs4097063; rs6048037; rs16983963; rs13037722; rs214767; rs11907667; rs214820; rs6113629; rs214808; rs17312424; rs11906052; rs11907611; rs214787; rs11906430; rs214826; rs6036088; rs17312557; rs214821; rs214816; rs214777; rs6137715; rs214758; rs214833; rs214760; rs6106479; rs214757; rs214759; rs6047968; rs1126815; rs1042617; rs1126816; rs7262519; rs1042616; rs34742355; rs1042619; rs6137724; rs6048260; rs1062606; rs6048079; rs33929365; rs34552910; rs2013747; rs6082710; rs35613469; rs35684829; rs11473649; rs3787473; rs41279950; rs11467463; rs5839945; rs386361; rs6106537; rs5839946; rs35424996; rs214761; rs6113616; rs6036100; rs6075919; rs7352716; rs4815128; rs6113697; rs36069184; rs41279944; rs34227867; rs214779; rs7274208; rs6137600; rs5839949; rs34897899; rs34732762; rs11306743; rs6082722; rs6137617; rs36005182; rs126635; rs3046692; rs6132496; rs7266030; rs11475094; rs6137714; rs6137692; rs6137626; rs11480651; rs6137630; rs11480978; rs11477297; rs5839947; rs35229399; rs6113662; rs16983510; rs11408471; rs36098753; rs34389451; rs11087374; rs11480073; rs36058748; rs4077078; rs6082758; rs6137719; rs6082713; rs7362352; rs13041201; rs11308962; rs4815136; rs6048201; rs6132522; rs6137631; rs6137678; rs34217881; rs6137693; rs6036164; rs41306767; rs35904800; rs34536259; rs6048227; rs35246388; rs35225328; rs34774705; rs7272782; rs13039090; rs214825; rs6082768; rs6113659; rs6137720; rs6113661; rs6082703; rs2422688; rs6082760; rs11477461; rs35025891; rs5839950; rs7267044; rs33923737; rs12625643; rs33928865; rs34205972; rs11473001; rs8114748; rs41279946; rs214822; rs6047989; rs6048251; rs6082667; rs34969915; rs7347951; rs6137677; rs11905253; rs34926550; rs35785069; rs11087382; rs6048164; rs33957405; rs5839948; rs35046905; rs7265785; rs214802; rs8119361; rs34849269; rs35654167; rs6137686; rs7262802; rs7269873; rs6048266; rs2235610; rs1040789; rs13038817; rs1474682; rs1534979; rs214750; rs214751; rs214752; rs214755; rs214834; rs214835; rs214839; rs2422694; rs2422695; rs2422696; rs2422697; rs35729063; rs4813467; rs4815145; rs5022516; rs5022517; rs6036066; rs6047936; rs6047963; rs6048274; rs6048276; rs6048338; rs6048339; rs6048340; rs6082631; rs6082632; rs6082633; rs6082805; rs6082806; rs6082807; rs6106553; rs6106556; rs6113558; rs6113559; rs6113563; rs6113793; rs6137560; rs7266599; rs7274418

# Metabolic_Enzyme_3_General_References:
8099584; 11780052

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5939

# Metabolic_Enzyme_4_Name:
Glutamate dehydrogenase 2, mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
GDH

# Metabolic_Enzyme_4_Gene_Name:
GLUD2

# Metabolic_Enzyme_4_Protein_Sequence:
>Glutamate dehydrogenase 2, mitochondrial precursor
MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAARRHYSELVADR
EDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSF
PIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFG
GAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTY
ASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFR
DKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILG
FPKAKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLER
NILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGK
HGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYV
NAIEKVFKVYSEAGVTFT

# Metabolic_Enzyme_4_Number_of_Residues:
558

# Metabolic_Enzyme_4_Molecular_Weight:
61435

# Metabolic_Enzyme_4_Theoretical_pI:
8.67

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_4_Specific_Function:
Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission

# Metabolic_Enzyme_4_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00251  Glutamate metabolism;
 map00330  Arginine and proline metabolism;
 map00471  D-Glutamine and D-glutamate metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_4_Reaction:
L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + ammonia + NAD(P)H + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00208:ELFV_dehydrog;
PF02812:ELFV_dehydrog_N

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.4.1.3

# Metabolic_Enzyme_4_GenBank_ID_Protein:
31815

# Metabolic_Enzyme_4_SwissProt_ID:
DHE4_HUMAN (P49448)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
GLUD2

# Metabolic_Enzyme_4_Geneatlas_id:
GLUD2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:4336

# Metabolic_Enzyme_4_PDB_ID:
1L1F

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_4_Gene_Sequence:
>1677 bp
ATGTACCGCTACCTGGCCAAAGCGCTGCTGCCGTCCCGGGCCGGGCCCGCTGCCCTGGGC
TCCGCGGCCAACCACTCGGCCGCGTTGCTGGGCCGGGGCCGCGGACAGCCCGCCGCCGCC
TCGCAGCCGGGGCTCGCATTGGCCGCCCGGCGCCACTACAGCGAGTTGGTGGCCGACCGC
GAGGACGACCCCAACTTCTTCAAGATGGTGGAGGGCTTCTTCGATCGCGGCGCCAGCATC
GTGGAGGACAAGTTGGTGAAGGACCTGAGGACCCAGGAAAGCGAGGAGCAGAAGCGGAAC
CGGGTGCGCGGCATCCTGCGGATCATCAAGCCCTGCAACCATGTGCTGAGTCTCTCCTTC
CCCATCCGGCGCGACGACGGCTCCTGGGAGGTCATCGAAGGCTACCGGGCCCAGCACAGC
CAGCACCGCACGCCCTGCAAGGGAGGTATCCGTTACAGCACTGATGTGAGTGTAGATGAA
GTAAAAGCTTTGGCTTCTCTGATGACATACAAGTGTGCAGTGGTTGATGTGCCGTTTGGG
GGTGCTAAAGCTGGTGTTAAGATCAATCCCAAGAACTATACCGAAAATGAATTGGAAAAG
ATCACAAGGAGGTTCACCATGGAGCTAGCAAAGAAGGGCTTTATTGGTCCTGGCGTTGAT
GTGCCTGCTCCAGACATGAACACAGGTGAGCGGGAGATGTCCTGGATTGCTGATACCTAT
GCCAGCACCATAGGGCACTATGATATTAATGCACACGCCTGTGTTACTGGTAAACCCATC
AGCCAAGGGGGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGGGATT
GAAAACTTCATCAATCAAGCTTCTTACATGAGCATTTTAGGAATGACACCAGGGTTTAGA
GATAAAACATTTGTTGTTCAGGGATTTGGTAATGTGGGCCTACACTCTATGAGATATTTA
CATCGTTTTGGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAATCCA
GATGGTATTGACCCAAAGGAACTGGAAGACTTCAAATTGCAACATGGGTCCATTCTGGGC
TTCCCCAAGGCAAAGCCCTATGAAGGAAGCATCTTGGAGGTCGACTGTGACATACTGATC
CCAGCTGCCACTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAAGATC
ATTGCTGAAGGTGCCAATGGGCCAACAACTCCAGAAGCTGATAAGATCTTCCTGGAGAGA
AACATTTTGGTTATTCCAGATCTCTACTTGAATGCTGGAGGAGTGACAGTATCTTACTTT
GAGTGGCTGAAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGAAAGG
GATTCTAACTACCACTTGCTCCTGTCTGTTCAAGAGAGTTTAGAAAGAAAATTTGGAAAG
CATGGTGGAACTATTCCCATTGTACCCACGGCAGAGTTCCAAGACAGTATATCGGGTGCA
TCTGAGAAAGACATTGTGCACTCTGCCTTGGCATACACAATGGAGCGTTCTGCCAGGCAA
ATTATGCACACAGCCATGAAGTATAACCTGGGATTGGACCTGAGAACAGCTGCCTATGTC
AATGCCATTGAAAAAGTCTTCAAAGTGTACAGTGAAGCTGGTGTGACCTTCACATAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
X66310

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_4_Locus:
Xq24-q25

# Metabolic_Enzyme_4_SNPs:
rs9697983; rs9780362; rs5909779; rs5911062; rs10657; rs1131121; rs28928873; rs41304944; rs1131120; rs12834131; rs3861; rs5956266; rs34294265; rs5956265; rs9698227; rs12836242; rs17329546; rs2375484; rs5956268; rs9699235; rs9778349

# Metabolic_Enzyme_4_General_References:
8207021

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5630

# Metabolic_Enzyme_5_Name:
Membrane copper amine oxidase

# Metabolic_Enzyme_5_Synonyms:
Semicarbazide-sensitive amine oxidase; SSAO; Vascular adhesion protein 1; VAP-1; HPAO

# Metabolic_Enzyme_5_Gene_Name:
AOC3

# Metabolic_Enzyme_5_Protein_Sequence:
>Membrane copper amine oxidase
MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVW
AEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHP
RGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDF
SDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSA
DSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN

# Metabolic_Enzyme_5_Number_of_Residues:
763

# Metabolic_Enzyme_5_Molecular_Weight:
84623

# Metabolic_Enzyme_5_Theoretical_pI:
6.51

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_5_Specific_Function:
Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity

# Metabolic_Enzyme_5_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_5_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_5_Signals:
1-19

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_5_GenBank_ID_Protein:
1399032

# Metabolic_Enzyme_5_SwissProt_ID:
AOC3_HUMAN (Q16853)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
AOC3

# Metabolic_Enzyme_5_Geneatlas_id:
AOC3

# Metabolic_Enzyme_5_hgnc_id:
HGNC:550

# Metabolic_Enzyme_5_PDB_ID:
1PU4

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_5_Gene_Sequence:
>2292 bp
ATGAACCAGAAGACAATCCTCGTGCTCCTCATTCTGGCCGTCATCACCATCTTTGCCTTG
GTTTGTGTCCTGCTGGTGGGCAGGGGTGGAGATGGGGGTGAACCCAGCCAGCTTCCCCAT
TGCCCCTCTGTATCTCCCAGTGCCCAGCCTTGGACACACCCTGGCCAGAGCCAGCTGTTT
GCAGACCTGAGCCGAGAGGAGCTGACGGCTGTGATGCGCTTTCTGACCCAGCGGCTGGGG
CCAGGGCTGGTGGATGCAGCCCAGGCCCGGCCCTCGGACAACTGTGTCTTCTCAGTGGAG
TTGCAGCTGCCTCCCAAGGCTGCAGCCCTGGCTCACTTGGACAGGGGGAGCCCCCCACCT
GCCCGGGAGGCACTGGCCATCGTCTTCTTTGGCAGGCAACCCCAGCCCAACGTGAGTGAG
CTGGTGGTGGGGCCACTGCCTCACCCCTCCTACATGCGGGACGTGACTGTGGAGCGTCAT
GGAGGCCCCCTGCCCTATCACCGACGCCCCGTGCTGTTCCAAGAGTACCTGGACATAGAC
CAGATGATCTTCAACAGAGAGCTGCCCCAGGCTTCTGGGCTTCTCCACCACTGTTGCTTC
TACAAGCACCGGGGACGGAACCTGGTGACAATGACCACGGCTCCCCGTGGTCTGCAATCA
GGGGACCGGGCCACCTGGTTTGGCCTCTACTACAACATCTCGGGCGCTGGGTTCTTCCTG
CACCACGTGGGCTTGGAGCTGCTAGTGAACCACAAGGCCCTTGACCCTGCCCGCTGGACT
ATCCAGAAGGTGTTCTATCAAGGCCGCTACTACGACAGCCTGGCCCAGCTGGAGGCCCAG
TTTGAGGCCGGCCTGGTGAATGTGGTGCTGATCCCAGACAATGGCACAGGTGGGTCCTGG
TCCCTGAAGTCCCCTGTGCCCCCGGGTCCAGCTCCCCCTCTACAGTTCTATCCCCAAGGC
CCCCGCTTCAGTGTCCAGGGAAGTCGAGTGGCCTCCTCACTGTGGACTTTCTCCTTTGGC
CTCGGAGCATTCAGTGGCCCAAGGATCTTTGACGTTCGCTTCCAAGGAGAAAGACTAGTT
TATGAGATAAGCCTCCAAGAGGCCTTGGCCATCTATGGTGGAAATTCCCCAGCAGCAATG
ACGACCCGCTATGTGGATGGAGGCTTTGGCATGGGCAAGTACACCACGCCCCTGACCCGT
GGGGTGGACTGCCCCTACTTGGCCACCTACGTGGACTGGCACTTCCTTTTGGAGTCCCAG
GCCCCCAAGACAATACGTGATGCCTTTTGTGTGTTTGAACAGAACCAGGGCCTCCCCCTG
CGGCGACACCACTCAGATCTCTACTCGCACTACTTTGGGGGTCTTGCGGAAACGGTGCTG
GTCGTCAGATCTATGTCCACCTTGCTCAACTATGACTATGTGTGGGATACGGTCTTCCAC
CCCAGTGGGGCCATAGAAATACGATTCTATGCCACGGGCTACATCAGCTCGGCATTCCTC
TTTGGTGCTACTGGGAAGTACGGGAACCAAGTGTCAGAGCACACCCTGGGCACGGTCCAC
ACCCACAGCGCCCACTTCAAGGTGGATCTGGATGTAGCAGGACTGGAGAACTGGGTCTGG
GCCGAGGATATGGTCTTTGTCCCCATGGCTGTGCCCTGGAGCCCTGAGCACCAGCTGCAG
AGGCTGCAGGTGACCCGGAAGCTGCTGGAGATGGAGGAGCAGGCCGCCTTCCTCGTGGGA
AGCGCCACCCCTCGCTACCTGTACCTGGCCAGCAACCACAGCAACAAGTGGGGTCACCCC
CGGGGCTACCGCATCCAGATGCTCAGCTTTGCTGGAGAGCCGCTGCCCCAAAACAGCTCC
ATGGCGAGAGGCTTCAGCTGGGAGAGGTACCAGCTGGCTGTGACCCAGCGGAAGGAGGAG
GAGCCCAGTAGCAGCAGCGTTTTCAATCAGAATGACCCTTGGGCCCCCACTGTGGATTTC
AGTGACTTCATCAACAATGAGACCATTGCTGGAAAGGATTTGGTGGCCTGGGTGACAGCT
GGTTTTCTGCATATCCCACATGCAGAGGACATTCCTAACACAGTGACTGTGGGGAACGGC
GTGGGCTTCTTCCTCCGACCCTATAACTTCTTTGACGAAGACCCCTCCTTCTACTCTGCC
GACTCCATCTACTTCCGAGGGGACCAGGATGCTGGGGCCTGCGAGGTCAACCCCCTAGCT
TGCCTGCCCCAGGCTGCTGCCTGTGCCCCCGACCTCCCTGCCTTCTCCCACGGGGGCTTC
TCTCACAACTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U39447

# Metabolic_Enzyme_5_Chromosome_Location:
Not Available

# Metabolic_Enzyme_5_Locus:
Not Available

# Metabolic_Enzyme_5_SNPs:
Not Available

# Metabolic_Enzyme_5_General_References:
8972912; 9653080

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5940

# Metabolic_Enzyme_6_Name:
Protein-glutamine gamma-glutamyltransferase 2

# Metabolic_Enzyme_6_Synonyms:
Tissue transglutaminase; TGase C; TGC; TG(C; Transglutaminase-2; TGase- H

# Metabolic_Enzyme_6_Gene_Name:
TGM2

# Metabolic_Enzyme_6_Protein_Sequence:
>Proteinglutamine gammaglutamyltransferase 2
MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFS
VVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLE
ASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPW
NFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGR
WDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTN
YNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPT
PQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSL
IVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVG
QSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEK
SVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQK
RKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMG
LHKLVVNFESDKLKAVKGFRNVIIGPA

# Metabolic_Enzyme_6_Number_of_Residues:
687

# Metabolic_Enzyme_6_Molecular_Weight:
77330

# Metabolic_Enzyme_6_Theoretical_pI:
4.86

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  peptide cross-linking
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins

# Metabolic_Enzyme_6_Pathway:
Not Available

# Metabolic_Enzyme_6_Reaction:
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00927:Transglut_C;
PF01841:Transglut_core;
PF00868:Transglut_N

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.3.2.13

# Metabolic_Enzyme_6_GenBank_ID_Protein:
339521

# Metabolic_Enzyme_6_SwissProt_ID:
TGM2_HUMAN (P21980)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
TGM2

# Metabolic_Enzyme_6_Geneatlas_id:
TGM2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:11778

# Metabolic_Enzyme_6_PDB_ID:
1KV3

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>2064 bp
ATGGCCGAGGAGCTGGTCTTAGAGAGGTGTGATCTGGAGCTGGAGACCAATGGCCGAGAC
CACCACACGGCCGACCTGTGCCGGGAGAAGCTGGTGGTGCGACGGGGCCAGCCCTTCTGG
CTGACCCTGCACTTTGAGGGCCGCAACTACCAGGCCAGTGTAGACAGTCTCACCTTCAGT
GTCGTGACCGGCCCAGCCCCTAGCCAGGAGGCCGGGACCAAGGCCCGTTTTCCACTAAGA
GATGCTGTGGAGGAGGGTGACTGGACAGCCACCGTGGTGGACCAGCAAGACTGCACCCTC
TCGCTGCAGCTCACCACCCCGGCCAACGCCCCCATCGGCCTGTATCGCCTCAGCCTGGAG
GCCTCCACTGGCTACCAGGGATCCAGCTTTGTGCTGGGCCACTTCATTTTGCTCTTCAAC
GCCTGGTGCCCAGCGGATGCTGTGTACCTGGACTCGGAAGAGGAGCGGCAGGAGTATGTC
CTCACCCAGCAGGGCTTTATCTACCAGGGCTCGGCCAAGTTCATCAAGAACATACCTTGG
AATTTTGGGCAGTTTCAAGATGGGATCCTAGACATCTGCCTGATCCTTCTAGATGTCAAC
CCCAAGTTCCTGAAGAACGCCGGCCGTGACTGCTCCCGGCGCAGCAGCCCCGTCTACGTG
GGCCGGGTGGGTAGTGGCATGGTCAACTGCAACGATGACCAGGGTGTGCTGCTGGGACGC
TGGGACAACAACTACGGGGACGGCGTCAGCCCCATGTCCTGGATCGGCAGCGTGGACATC
CTGCGGCGCTGGAAGAACCACGGCTGCCAGCGCGTCAAGTATGGCCAGTGCTGGGTCTTC
GCCGCCGTGGCCTGCACAGTGCTGAGGTGCCTAGGCATCCCTACCCGCGTCGTGACCAAC
TACAACTCGGCCCATGACCAGAACAGCAACCTTCTCATCGAGTACTTCCGCAATGAGTTT
GGGGAGATCCAGGGTGACAAGAGCGAGATGATCTGGAACTTCCACTGCTGGGTGGAGTCG
TGGATGACCAGGCCGGACCTGCAGCCGGGGTACGAGGGCTGGCAGGCCCTGGACCCAACG
CCCCAGGAGAAGAGCGAAGGAACGTACTGCTGTGGCCCAGTTCCAGTTCGTGCCATCAAG
GAGGGCGACCTGAGCACCAAGTACGATGCGCCCTTTGTCTTTGCGGAGGTCAATGCCGAC
GTGGTAGACTGGATCCAGCAGGACGATGGGTCTGTGCACAAATCCATCAACCGTTCCCTG
ATCGTTGGGCTGAAGATCAGCACTAAGAGCGTGGGCCGAGACGAGCGGGAGGATATCACC
CACACCTACAAATACCCAGAGGGGTCCTCAGAGGAGAGGGAGGCCTTCACAAGGGCGAAC
CACCTGAACAAACTGGCCGAGAAGGAGGAGACAGGGATGGCCATGCGGATCCGTGTGGGC
CAGAGCATGAACATGGGCAGTGACTTTGACGTCTTTGCCCACATCACCAACAACACCGCT
GAGGAGTACGTCTGCCGCCTCCTGCTCTGTGCCCGCACCGTCAGCTACAATGGGATCTTG
GGGCCCGAGTGTGGCACCAAGTACCTGCTCAACCTAACCCTGGAGCCTTTCTCTGAGAAG
AGCGTTCCTCTTTGCATCCTCTATGAGAAATACCGTGACTGCCTTACGGAGTCCAACCTC
ATCAAGGTGCGGGCCCTCCTCGTGGAGCCAGTTATCAACAGCTACCTGCTGGCTGAGAGG
GACCTCTACCTGGAGAATCCAGAAATCAAGATCCGGATCCTTGGGGAGCCCAAGCAGAAA
CGCAAGCTGGTGGCTGAGGTGTCCCTGCAGAACCCGCTCCCTGTGGCCCTGGAAGGCTGC
ACCTTCACTGTGGAGGGGGCCGGCCTGACTGAGGAGCAGAAGACGGTGGAGATCCCAGAC
CCCGTGGAGGCAGGGGAGGAAGTTAAGGTGAGAATGGACCTCGTGCCGCTCCACATGGGC
CTCCACAAGCTGGTGGTGAACTTCGAGAGCGACAAGCTGAAGGCTGTGAAGGGCTTCCGG
AATGTCATCATTGGCCCCGCCTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M55153

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_6_Locus:
20q12

# Metabolic_Enzyme_6_SNPs:
rs2294545; rs2235581; rs2076390; rs1044932; rs2284879; rs6123388; rs7271155; rs4811529; rs2284881; rs2076385; rs2076378; rs6023526; rs6023476; rs2284877; rs2076380; rs6023511; rs4811528; rs1555074; rs6023533; rs2076387; rs16987150; rs2076383; rs7270785; rs7270898; rs11696730; rs6123394; rs2284878; rs2076389; rs2268909; rs2076391; rs2268912; rs12624511; rs2076388; rs2268910; rs2067027; rs6014121; rs6127224; rs2284882; rs2268911; rs16987159; rs11907951; rs2072951; rs6127225; rs2281197; rs2268908; rs2076386; rs8118753; rs2076377; rs17196913; rs7270605; rs17789803; rs17789815; rs17197018; rs6512993; rs2076379; rs13040190; rs7275079; rs2076384; rs6127240; rs7265437; rs6023527; rs8116393; rs6023418; rs7271165; rs12481711; rs6023525; rs17196927; rs2268907; rs2281198; rs2284880; rs17789761; rs2235583; rs6127200; rs2076381; rs2235582; rs2076382; rs7272112; rs41274720; rs35700485; rs1062735; rs41274716; rs2229470; rs6023252; rs2229471; rs2229472; rs35434048; rs1804502; rs11387; rs6097978; rs36046775; rs11550896; rs1804503; rs2281196; rs7270628; rs1062737; rs6097985; rs1062736; rs1044857; rs6068886; rs6023279; rs5018735; rs5841287; rs6091906; rs34548736; rs6023597; rs35284639; rs6127242; rs6091943; rs8117902; rs17787661; rs11469099; rs6023414; rs6127267; rs6098150; rs35780805; rs8114400; rs13040847; rs34739100; rs6068885; rs10699981; rs10699740; rs6098131; rs6023598; rs34654943; rs6091944; rs8124100; rs6068900; rs11471691; rs6091968; rs6098128; rs8183332; rs41274712; rs6091945; rs6068899; rs35004302; rs6023334; rs8123979; rs34607641; rs6098189; rs35565395; rs7363366; rs34321768; rs6023452; rs2268906; rs11468662; rs6098132; rs6098085; rs11269756; rs4811518; rs8121932; rs11468425; rs6023490; rs9636518; rs10616642; rs12481464; rs11470829; rs6091926; rs6014113; rs34897797; rs7268761; rs34622978; rs35107341; rs6127243; rs35785941; rs35526991; rs2294544; rs6098144; rs6098100; rs6023588; rs34046288; rs6023261; rs6023306; rs13041056; rs6098012; rs6068979; rs34211491; rs6068984; rs13045658; rs6068985; rs36103548; rs13037122; rs11469340; rs34175510; rs11086467; rs11086468; rs11698193; rs11698249; rs11698616; rs11698668; rs11700009; rs11700046; rs11700099; rs12480485; rs12624989; rs12626000; rs13040344; rs13040645; rs13043826; rs13045359; rs13045391; rs13045748; rs13045832; rs17197200; rs17197207; rs17790012; rs1883484; rs34773869; rs34784193; rs6013988; rs6013993; rs6014186; rs6014193; rs6023630; rs6023637; rs6023651; rs6023654; rs6023676; rs6064122; rs6069014; rs6069015; rs6097929; rs6098295; rs742414; rs760999; rs761001; rs761002; rs761003; rs8116328; rs8121713

# Metabolic_Enzyme_6_General_References:
1670766; 1358880; 8611626; 11780052

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5941

# Metabolic_Enzyme_7_Name:
Protein-arginine deiminase type-6

# Metabolic_Enzyme_7_Synonyms:
Protein-arginine deiminase type VI; Peptidylarginine deiminase VI

# Metabolic_Enzyme_7_Gene_Name:
PADI6

# Metabolic_Enzyme_7_Protein_Sequence:
>Proteinarginine deiminase type6
MSFQSIIHLSLDSPVHAVCVLGTEICLDLSGCAPQKCQCFTIHGSGRVLIDVANTVISEK
EDATIWWPLSDPTYATVKMTSPSPSVDADKVSVTYYGPNEDAPVGTAVLYLTGIEVSLEV
DIYRNGQVEMSSDKQAKKKWIWGPSGWGAILLVNCNPADVGQQLEDKKTKKVIFSEEITN
LSQMTLNVQGPSCILKKYRLVLHTSKEESKKARVYWPQKDNSSTFELVLGPDQHAYTLAL
LGNHLKETFYVEAIAFPSAEFSGLISYSVSLVEESQDPSIPETVLYKDTVVFRVAPCVFI
PCTQVPLEVYLCRELQLQGFVDTVTKLSEKSNSQVASVYEDPNRLGRWLQDEMAFCYTQA
PHKTTSLILDTPQAADLDEFPMKYSLSPGIGYMIQDTEDHKVASMDSIGNLMVSPPVKVQ
GKEYPLGRVLIGSSFYPSAEGRAMSKTLRDFLYAQQVQAPVELYSDWLMTGHVDEFMCFI
PTDDKNEGKKGFLLLLASPSACYKLFREKQKEGYGDALLFDELRADQLLSNGREAKTIDQ
LLADESLKKQNEYVEKCIHLNRDILKTELGLVEQDIIEIPQLFCLEKLTNIPSDQQPKRS
FARPYFPDLLRMIVMGKNLGIPKPFGPQIKGTCCLEEKICCLLEPLGFKCTFINDFDCYL
TEVGDICACANIRRVPFAFKWWKMVP

# Metabolic_Enzyme_7_Number_of_Residues:
686

# Metabolic_Enzyme_7_Molecular_Weight:
76898

# Metabolic_Enzyme_7_Theoretical_pI:
4.90

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Function:  protein-arginine deiminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Catalyzes the deimination of arginine residues of proteins. May be involved in cytoskeletal reorganization in the egg and early embryo

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
protein L-arginine + H2O = protein L-citrulline + NH3

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF03068:PAD;
PF08527:PAD_M;
PF08526:PAD_N

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.5.3.15

# Metabolic_Enzyme_7_GenBank_ID_Protein:
40068449

# Metabolic_Enzyme_7_SwissProt_ID:
PADI6_HUMAN (Q6TGC4)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
PADI6

# Metabolic_Enzyme_7_Geneatlas_id:
PADI6

# Metabolic_Enzyme_7_hgnc_id:
HGNC:20449

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm. Nucleus (By similarity)

# Metabolic_Enzyme_7_Gene_Sequence:
>2085 bp
ATGGTCAGCGTGGAGGGCCGAGCCATGTCCTTCCAGAGTATCATCCACCTGTCCCTGGAC
AGCCCTGTCCATGCCGTTTGTGTGTTGGGCACAGAAATCTGCTTGGATCTCAGCGGGTGT
GCCCCCCAGAAGTGCCAGTGCTTCACCATCCATGGCTCTGGGAGGGTCTTGATCGATGTG
GCCAACACGGTGATTTCTGAGAAGGAGGACGCCACCATCTGGTGGCCCCTGTCTGATCCC
ACGTACGCCACAGTGAAGATGACATCGCCCAGCCCTTCCGTGGATGCGGATAAGGTCTCG
GTCACATACTATGGGCCCAACGAGGATGCCCCCGTGGGCACAGCTGTGCTGTACCTCACT
GGCATTGAGGTCTCTCTAGAGGTAGACATCTACCGCAATGGGCAAGTTGAGATGTCAAGT
GACAAACAGGCTAAGAAAAAATGGATCTGGGGTCCCAGCGGTTGGGGTGCCATCCTGCTT
GTGAATTGCAACCCTGCTGATGTGGGCCAGCAACTTGAGGACAAGAAAACCAAGAAAGTG
ATCTTTTCAGAGGAAATAACGAATCTGTCCCAGATGACTCTGAATGTCCAAGGCCCCAGC
TGTATCTTAAAGAAATATCGGCTAGTCCTCCATACCTCCAAGGAAGAGTCGAAGAAGGCG
AGAGTCTACTGGCCCCAAAAAGACAACTCCAGTACCTTTGAGTTGGTGCTGGGGCCCGAC
CAGCACGCCTATACCTTGGCCCTCCTCGGGAACCACTTGAAGGAGACTTTCTACGTTGAA
GCTATAGCATTCCCATCTGCCGAATTCTCAGGCCTCATCTCCTACTCTGTGTCCCTGGTG
GAGGAGTCTCAAGACCCGTCAATTCCAGAGACTGTGCTGTACAAAGACACGGTGGTGTTC
CGGGTGGCTCCCTGTGTCTTCATTCCCTGTACCCAGGTGCCTCTGGAGGTTTACCTGTGC
AGGGAGCTGCAGCTGCAGGGTTTTGTGGACACAGTGACGAAGCTGAGTGAGAAGAGCAAC
AGCCAGGTGGCATCTGTCTATGAGGACCCCAACCGCCTGGGCAGGTGGCTCCAGGATGAG
ATGGCCTTCTGCTACACCCAGGCTCCCCACAAGACAACGTCCTTGATCCTCGACACACCT
CAGGCCGCCGATCTCGATGAGTTCCCCATGAAGTACTCACTGAGCCCTGGTATTGGCTAC
ATGATCCAGGACACTGAGGACCATAAAGTGGCCAGCATGGATTCCATTGGGAACCTGATG
GTGTCCCCACCTGTCAAGGTCCAAGGGAAAGAGTACCCGCTGGGCAGAGTCCTCATTGGC
AGCAGCTTTTACCCCAGCGCAGAGGGCCGGGCCATGAGTAAGACCCTCCGAGACTTCCTC
TATGCCCAGCAGGTCCAAGCGCCGGTGGAGCTCTACTCAGATTGGCTAATGACTGGCCAC
GTGGATGAGTTCATGTGCTTCATCCCCACAGATGACAAGAATGAGGGCAAAAAGGGCTTC
CTGCTGCTCCTGGCCAGCCCCAGTGCCTGCTATAAACTGTTCCGAGAGAAACAGAAGGAA
GGCTATGGCGACGCTCTTCTGTTTGATGAGCTTAGAGCAGATCAGCTCCTGTCTAATGGA
AGGGAAGCCAAAACCATCGACCAACTTCTGGCTGATGAAAGCCTGAAGAAGCAGAATGAA
TACGTGGAGAAGTGCATTCACCTGAACCGTGACATCCTGAAGACGGAGCTGGGCCTGGTG
GAACAGGACATCATCGAGATTCCCCAGCTGTTCTGCTTGGAGAAGCTGACTAACATCCCC
TCTGACCAGCAGCCCAAGAGGTCCTTTGCGAGGCCATACTTCCCTGACCTGTTGCGGATG
ATTGTGATAGGCAAGAACCTGGGGATCCCCAAGCCTTTTGGGCCCCAAATCAAGGGGACC
TGCTGCCTGGAAGAAAAGATTTGCTGCTTGCTGGAGCCCCTGGGCTTCAAGTGCACCTTC
ATCAATGACTTTGACTGTTACCTGACAGAGGTCGGAGACATCTGTGCCTGTGCCAACATC
CGCCGGGTGCCCTTTACCTTCAAATGGTGGAAGATGGTACCTTAG

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AY422079

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_7_Locus:
1p36.13

# Metabolic_Enzyme_7_SNPs:
rs2526830; rs1204873; rs11584277; rs1535876; rs2526844; rs2181867; rs2762895; rs2762894; rs2800688; rs1204871; rs2248453; rs2762896; rs7529038; rs1544066; rs6678552; rs2526839; rs2762893; rs2800691; rs12563231; rs10788668; rs4920602; rs2526840; rs1544067; rs1544068; rs7545115; rs11590561; rs7538876; rs7545226; rs6669650; rs6656582; rs2526842; rs6691485; rs2526836; rs7523430; rs942459; rs7513817; rs6695097; rs6678121; rs2762892; rs6695849; rs2526841; rs6666031; rs10458537; rs2800689; rs7545237; rs6678027; rs12737852; rs2526833; rs2265027; rs2526837; rs6696295; rs2800690; rs1535875; rs6678127; rs6695214; rs1204898; rs4920603; rs10158217; rs11803961; rs16826190; rs6687773; rs12068882; rs6666424; rs1204866; rs2248452; rs6703392; rs2248568; rs12124893; rs2800693; rs11203377; rs6658538; rs2526834; rs1555663; rs6663329; rs6695531; rs11803970; rs1204867; rs2248812; rs2800692; rs12073549; rs1204868; rs10458538; rs11577716; rs11203376; rs6695640; rs12025170; rs12127366; rs12239645; rs6664321; rs1535877; rs2800694; rs2248450; rs1204864; rs7519272; rs12752370; rs6586535; rs6700319; rs6687881; rs2308230; rs10888032; rs11800039; rs1204869; rs7556072; rs12127405; rs1924553; rs10888028; rs1204872; rs6657529; rs11583480; rs2489606; rs7523534; rs10888031; rs1204875; rs1204880; rs1204876; rs2526829; rs12760347; rs1204874; rs16825990; rs2107681; rs1204877; rs1204879; rs12753129; rs1204878; rs34167614; rs2489608; rs2762898; rs12023647; rs34009697; rs2526831; rs12128561; rs35174721; rs12031545; rs12129196; rs34553706; rs28449475; rs34042084; rs34037282; rs12736038; rs7533691; rs2265729; rs2526835; rs12132237; rs1204900; rs12129263; rs12071723; rs34308317; rs10690473; rs35811755; rs35164410; rs35274905; rs35046597; rs35288737; rs35197313; rs1924556; rs5772756; rs35871277; rs3035574; rs7553780; rs12132197; rs3094884; rs11338972; rs3035576; rs34171437; rs28416873; rs34761211; rs11584962; rs34548121; rs35317817; rs34383177; rs1555657; rs35411562; rs34724514; rs16826167; rs2800695; rs35226820; rs34852297; rs5772757; rs11584850; rs12134662; rs10709483; rs34075690; rs35726973; rs35213099; rs10158844; rs34586605; rs11309669; rs35317545; rs12028068; rs12023951; rs34944809; rs35968619; rs34543932; rs35163797; rs36067110; rs2477149; rs34438954; rs1924555; rs35154138; rs1204899; rs35775800; rs11584417; rs34518731; rs34520845; rs11800087; rs34330993; rs2526843; rs12079277; rs11410245; rs1555656; rs2489607; rs34766695; rs34018214; rs1204865; rs12033821; rs1555662; rs1211389; rs2526832; rs3074251; rs1204901; rs2265728; rs1924554; rs2762897; rs35813335; rs7541044; rs11203375; rs12743482; rs7540925; rs11203374; rs11583421; rs11801266; rs11809800; rs1204881; rs1204882; rs1204883; rs1204884; rs1204890; rs1204891; rs1204892; rs1204897; rs12059782; rs12096509; rs12098152; rs12732819; rs12760504; rs1408422; rs1408423; rs1555661; rs1969829; rs2244936; rs2477150; rs2526827; rs2762887; rs2762889; rs2762890; rs2800699; rs3094885; rs3752351; rs6690363; rs717612; rs7512868; rs7513051; rs7534816; rs7538597

# Metabolic_Enzyme_7_General_References:
Not Available

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5230

# Metabolic_Enzyme_8_Name:
Deoxycytidylate deaminase

# Metabolic_Enzyme_8_Synonyms:
dCMP deaminase

# Metabolic_Enzyme_8_Gene_Name:
DCTD

# Metabolic_Enzyme_8_Protein_Sequence:
>Deoxycytidylate deaminase
MSEVSCKKRDDYLEWPEYFMAVAFLSAQRSKDPNSQVGACIVNSENKIVGIGYNGMPNGC
SDDVLPWRRTAENKLDTKYPYVCHAELNAIMNKNSTDVKGCSMYVALFPCNECAKLIIQA
GIKEVIFMSDKYHDSDEATAARLLFNMAGVTFRKFIPKCSKIVIDFDSINSRPSQKLQ

# Metabolic_Enzyme_8_Number_of_Residues:
178

# Metabolic_Enzyme_8_Molecular_Weight:
20016

# Metabolic_Enzyme_8_Theoretical_pI:
7.65

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Supplies the nucleotide substrate for thymidylate synthetase

# Metabolic_Enzyme_8_Pathway:
map00240  Pyrimidine metabolism;
 map03090  Type II secretion system

# Metabolic_Enzyme_8_Reaction:
dCMP + H2O = dUMP + ammonia

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00383:dCMP_cyt_deam_1

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.5.4.12

# Metabolic_Enzyme_8_GenBank_ID_Protein:
181537

# Metabolic_Enzyme_8_SwissProt_ID:
DCTD_HUMAN (P32321)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
DCTD

# Metabolic_Enzyme_8_Geneatlas_id:
DCTD

# Metabolic_Enzyme_8_hgnc_id:
HGNC:2710

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_8_Gene_Sequence:
>537 bp
ATGAGTGAAGTTTCCTGCAAGAAACGGGACGACTATTTGGAATGGCCAGAGTATTTTATG
GCTGTGGCCTTCTTATCAGCACAGAGAAGCAAAGATCCAAATTCCCAGGTCGGCGCCTGC
ATCGTGAATTCAGAAAACAAGATTGTCGGGATTGGGTACAATGGGATGCCAAATGGGTGC
AGTGATGACGTGTTGCCTTGGAGAAGGACAGCAGAGAATAAGCTGGACACCAAATACCCG
TACGTGTGCCATGCGGAGCTGAATGCCATCATGAACAAAAATTCGACCGATGTGAAAGGC
TGTAGTATGTATGTCGCCTTGTTCCCTTGTAATGAATGCGCTAAGCTCATCATCCAGGCA
GGTATAAAAGAAGTGATTTTCACGTCTGATAAATACCATGATAGTGACGAGGCAACTGCT
GCGAGGCTCCTGTTTAATATGGCCGGGGTGACATTCCGGAAATTCATACCGAAGTGCAGC
AAGATTGTCATTGACTTTGATTCAATTAACAGCAGACCGAGTCAAAAGCTTCAGTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
L12136

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_8_Locus:
4q35.1

# Metabolic_Enzyme_8_SNPs:
rs7663494; rs6552619; rs35431896; rs7277; rs9542; rs7278; rs3190314; rs3088349; rs1130902; rs851; rs13114262; rs3811810; rs7662393; rs2515683; rs6834019; rs9993882; rs12499918; rs7688644; rs6552622; rs6552621; rs6552620; rs10016530; rs1960207; rs9990999; rs2464974; rs9993866; rs12507552; rs13116598; rs17074237; rs6831306; rs13139377; rs13148414; rs11730323; rs6823077; rs17331744; rs10520543; rs10009825; rs13143433; rs17331968; rs10017797; rs7688234; rs3886768; rs4546291; rs13119957; rs2709338; rs13125711; rs2854557; rs13117591; rs13150570; rs13101260; rs11944044; rs2854559; rs7695216; rs13147196; rs13111117; rs13114435; rs13116494; rs1960206; rs2070805; rs2709339; rs13143259; rs6854046; rs3886767; rs17074241; rs17272416; rs17272827; rs6834432; rs11943452; rs17074230; rs2006129; rs13117700; rs34691926; rs3895619; rs13137332; rs7677967; rs6835318; rs6829021; rs11132157; rs6829309; rs11132159; rs6834938; rs17271644; rs11945824; rs12644483; rs17074255; rs11132158; rs6834968; rs17271665; rs7670780; rs17074179; rs17849458; rs35932500; rs13115133; rs34258479; rs2854558; rs1803485; rs11542955; rs978; rs4371655; rs2854556; rs34601043; rs34694727; rs34180264; rs35991374; rs35657813; rs10001362; rs34737293; rs11378889; rs13130566; rs34191514; rs28395501; rs2709340; rs35619807; rs2464971; rs2464970; rs35369968; rs35677082; rs34615053; rs34446316; rs34895822; rs17331996; rs13132293; rs34832772; rs33980005; rs34915632; rs2709342; rs35309711; rs28433797; rs12498969; rs33920727; rs7678108; rs10547938; rs13143535; rs5864809; rs2709345; rs35975848; rs34083060; rs34254701; rs35058226; rs36106622; rs13106308; rs2854553; rs35733975; rs2464969; rs35563105; rs34342056; rs7440120; rs28373940; rs2854554; rs34429408; rs2709344; rs35792362; rs34577883; rs35582993; rs35092526; rs13105019; rs13131376; rs34891001; rs2709341; rs6838091; rs28666432; rs17332045; rs28490576; rs2515682; rs13136805; rs34675565; rs13123593; rs17074254; rs35418900; rs35317026; rs35537259; rs6856058; rs35212179; rs35709318; rs13137448; rs6852733; rs35337615; rs35515009; rs34709418; rs34162150; rs2854555; rs35175712; rs13131621; rs13117695; rs4541550; rs34952576; rs36086271; rs35583609; rs34090309; rs34860877; rs34272834; rs6811849; rs35549969; rs33954687; rs7678159; rs28579927; rs10005703; rs10011977; rs11726024; rs13116781; rs17074171; rs17074271; rs17074273; rs17074277; rs3924787; rs3924788; rs3924789; rs4073674; rs4073675; rs4073676; rs4266328; rs4421026; rs4518294; rs4522909; rs4579170; rs4861536; rs4862127; rs5016499; rs5024188; rs6842533; rs7663810; rs7663998; rs7698606

# Metabolic_Enzyme_8_General_References:
7685356; 7642519

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5942

# Metabolic_Enzyme_9_Name:
Coagulation factor XIII B chain precursor

# Metabolic_Enzyme_9_Synonyms:
Protein-glutamine gamma- glutamyltransferase B chain; Transglutaminase B chain; Fibrin- stabilizing factor B subunit

# Metabolic_Enzyme_9_Gene_Name:
F13B

# Metabolic_Enzyme_9_Protein_Sequence:
>Coagulation factor XIII B chain precursor
MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCL
AGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCAS
GYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYEC
ATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFF
CHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHI
ECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKV
TYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSS
VEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGD
LIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTV
DTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDF
DNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQSTLSYQEPLR
T

# Metabolic_Enzyme_9_Number_of_Residues:
661

# Metabolic_Enzyme_9_Molecular_Weight:
75511

# Metabolic_Enzyme_9_Theoretical_pI:
6.36

# Metabolic_Enzyme_9_GO_Classification:
Not Available

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin

# Metabolic_Enzyme_9_Pathway:
Not Available

# Metabolic_Enzyme_9_Reaction:
Not Available

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00084:Sushi

# Metabolic_Enzyme_9_Signals:
1-20

# Metabolic_Enzyme_9_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.3.2.13

# Metabolic_Enzyme_9_GenBank_ID_Protein:
179417

# Metabolic_Enzyme_9_SwissProt_ID:
F13B_HUMAN (P05160)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
F13B

# Metabolic_Enzyme_9_Geneatlas_id:
F13B

# Metabolic_Enzyme_9_hgnc_id:
HGNC:3534

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Not Available

# Metabolic_Enzyme_9_Gene_Sequence:
>1986 bp
ATGAGGTTGAAAAACCTGACTTTTATCATCATATTGATAATCTCAGGAGAACTCTATGCA
GAAGAGAAACCCTGTGGTTTTCCTCATGTGGAAAATGGAAGAATTGCCCAATATTACTAT
ACTTTTAAAAGCTTTTACTTTCCAATGAGCATAGACAAAAAATTGTCATTTTTCTGCTTG
GCTGGTTATACCACTGAAAGTGGAAGACAAGAAGAGCAAACCACGTGTACAACAGAAGGC
TGGTCTCCAGAGCCAAGGTGCTTCAAAAAATGCACTAAGCCTGACCTGAGTAATGGTTAC
ATCTCTGATGTAAAGTTATTGTATAAAATTCAAGAGAACATGCATTATGGTTGCGCTTCA
GGGTACAAAACCACTGGAGGGAAGGATGAAGAAGTGGTTCAATGTCTCTCTGATGGATGG
TCTTCTCAACCAACCTGTAGGAAAGAACATGAAACGTGTTTGGCTCCTGAATTATATAAT
GGAAATTATTCCACAACACAGAAAACATTCAAAGTGAAGGACAAAGTACAATACGAATGT
GCTACTGGCTACTACACAGCTGGAGGAAAGAAGACAGAGGAGGTAGAATGTCTCACATAC
GGATGGTCTCTCACACCAAAATGTACCAAATTAAAGTGCTCTTCTTTAAGATTAATTGAA
AATGGTTATTTTCATCCTGTAAAGCAAACCTATGAAGAAGGAGATGTCGTTCAGTTTTTC
TGTCATGAAAATTATTATCTAAGTGGATCTGATTTAATTCAATGCTATAACTTTGGTTGG
TACCCAGAATCTCCTGTATGCGAAGGAAGAAGAAACAGATGTCCTCCTCCACCTCTGCCC
ATAAACTCCAAAATTCAAACACATTCAACAACTTATCGTCATGGAGAAATAGTTCATATA
GAATGTGAACTTAATTTTGAGATCCATGGGTCAGCAGAAATACGTTGTGAAGATGGAAAA
TCGACAGAACCTCCAAAATGCATTGAAGGACAGGAGAAGGTAGCCTGTGAGGAACCACCC
TTCATTGAAAATGGTGCAGCAAATTTACACTCTAAGATTTATTACAATGGGGATAAAGTG
ACATATGCATGTAAAAGCGGCTACCTTCTCCATGGATCGAATGAGATAACTTGTAATCGT
GGAAAATGGACACTTCCTCCTGAGTGTGTTGAAAATAATGAGAATTGTAAGCATCCTCCT
GTTGTAATGAATGGGGCTGTTGCAGACGGGATATTGGCAAGCTATGCAACAGGATCCTCA
GTGGAATATAGATGCAATGAATATTACTTACTGAGGGGATCAAAAATATCTCGTTGCGAA
CAAGGAAAATGGTCATCCCCACCTGTTTGCTTGGAACCATGTACTGTTAATGTGGATTAC
ATGAACAGAAATAACATAGAAATGAAGTGGAAATATGAAGGGAAAGTCTTACATGGAGAT
TTAATAGATTTTGTATGTAAACAGGGATATGACTTATCTCCATTAACCCCATTGTCTGAA
TTATCTGTGCAGTGCAACAGAGGAGAAGTGAAATATCCTTTATGTACTAGAAAAGAATCT
AAAGGAATGTGCACATCTCCTCCTCTTATTAAACATGGAGTCATTATTAGTTCAACAGTA
GACACCTATGAAAATGGCTCTTCAGTAGAATACAGATGTTTTGATCACCATTTCCTAGAA
GGATCTAGGGAGGCCTATTGTTTAGATGGAATGTGGACTACACCACCATTGTGTTTAGAG
CCATGCACATTATCTTTTACTGAAATGGAAAAGAATAATTTACTTCTGAAATGGGATTTT
GACAACAGACCACACATTTTGCATGGTGAATATATTGAGTTTATTTGTAGAGGAGATACT
TATCCAGCTGAATTATATATTACTGGATCTATACTTAGAATGCAATGTGACAGAGGGCAG
TTAAAATATCCAAGATGTATTCCAAGACAAAGCACTCTGTCTTATCAAGAACCCTTAAGA
ACATAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
M64554

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_9_Locus:
1q31-q32.1

# Metabolic_Enzyme_9_SNPs:
rs6003; rs5999; rs6000; rs5998; rs5994; rs5997; rs698859; rs17549873; rs1759013; rs1615413; rs857026; rs5990; rs2990510; rs1611982; rs5996; rs857018; rs1627765; rs1412635; rs2298882; rs1412633; rs857020; rs10801586; rs10754211; rs10754210; rs7518773; rs1794003; rs1759006; rs1332661; rs2298883; rs5993; rs1759009; rs1412634; rs1759007; rs11587174; rs10640299; rs17514606; rs12134960; rs857024; rs1102176; rs865071; rs4915148; rs7517428; rs1759008; rs6669388; rs11586343; rs17549589; rs6669176; rs857017; rs11311263; rs10484502; rs17514514; rs857025; rs17549277; rs6669374; rs857027; rs10754209; rs17514662; rs17549603; rs17514324; rs17549657; rs17549381; rs17549755; rs17514507; rs17514528; rs17514570; rs17514556; rs17549540; rs17549769; rs17514591; rs17549430; rs17514802; rs17549547; rs17514577; rs17514382; rs17514274; rs17549624; rs17549734; rs17514396; rs17514355; rs17549776; rs17514795; rs17514362; rs17549312; rs17514627; rs17514634; rs17514669; rs11810678; rs17514403; rs17514521; rs17514309; rs17549650; rs17549617; rs17549664; rs17514535; rs17549582; rs17514732; rs10922158; rs17549797; rs17514760; rs17549360; rs17549818; rs17514823; rs17549596; rs17514584; rs17514739; rs17514781; rs17514725; rs17549866; rs17514767; rs17549859; rs17549256; rs17514676; rs17514317; rs1412632; rs1412631; rs13375369; rs857021; rs1115246; rs1115247; rs857023; rs17549514; rs17514851; rs5991; rs12752075; rs17549671; rs17514281; rs12732168; rs6001; rs6002; rs12752091; rs2990511; rs17514253; rs5992; rs36059396; rs35313992; rs10574253; rs35445601; rs17514288; rs17549783; rs17549790; rs17514480; rs1759012; rs17514232; rs17514746; rs13375546; rs17549388; rs35716835; rs17514704; rs7542706; rs17549643; rs17514542; rs17514697; rs17549706; rs1794007; rs17514376; rs1759010; rs17514648; rs1794004; rs17549416; rs17514239; rs17514809; rs12734951; rs17549575; rs17549465; rs17549762; rs17514487; rs12735136; rs17514302; rs17549748; rs17514816; rs17549533; rs17514641; rs17549554; rs12139015; rs17514369; rs34101135; rs17514753; rs1794009; rs17549839; rs17549713; rs17514620; rs17549699; rs17549631; rs17549853; rs17514613; rs12735137; rs17549561; rs17549741; rs17549804; rs17549568; rs17549846; rs17514683; rs857019; rs1759011; rs12753471; rs35806759; rs34632479; rs17514774; rs17549832; rs17514563; rs35750720; rs36007443; rs17514494; rs35523548; rs17549825; rs17549720; rs6670146; rs17514788; rs17549636; rs5995; rs17514549; rs17514655; rs10577078; rs6672693; rs17514424; rs17549374; rs17514501; rs17549685; rs1759020; rs17549811; rs17549228; rs11438239; rs11450625; rs17549214; rs17514191; rs17514466; rs7411133; rs17549521; rs857022; rs17514459; rs12724830; rs17514843; rs10643350; rs17549527; rs17514473; rs17549507; rs34488858; rs35493286; rs41265223; rs17514830; rs10719375; rs34232043; rs34690792; rs10737685; rs12075161; rs12077334; rs12140782; rs12724676; rs1332668; rs1332669; rs1412639; rs2336595; rs6661664; rs6691224; rs6693887; rs6702252; rs7418993; rs7545829; rs7554881

# Metabolic_Enzyme_9_General_References:
2271707; 3021194; 2339067; 8324218; 10391209

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5943

# Metabolic_Enzyme_10_Name:
Glutamine synthetase

# Metabolic_Enzyme_10_Synonyms:
Glutamate--ammonia ligase; GS

# Metabolic_Enzyme_10_Gene_Name:
GLUL

# Metabolic_Enzyme_10_Protein_Sequence:
>Glutamine synthetase
MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEW
NFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRI
MDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHY
RACLYAGVKIAGTNAEVMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDP
KPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRL
TGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCL
LNETGDEPFQYKN

# Metabolic_Enzyme_10_Number_of_Residues:
373

# Metabolic_Enzyme_10_Molecular_Weight:
42065

# Metabolic_Enzyme_10_Theoretical_pI:
6.88

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  acid-ammonia (or amide) ligase activity
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  acid-ammonia (or amide) ligase activity
Function:  ammonia ligase activity
Function:  glutamate-ammonia ligase activity
 ||
>>>
Process:  nitrogen compound metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
Process:  glutamine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine

# Metabolic_Enzyme_10_Pathway:
map00251  Glutamate metabolism;
 map00550  Peptidoglycan biosynthesis;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_10_Reaction:
ATP + L-glutamate + ammonia = ADP + phosphate + L-glutamine

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00120:Gln-synt_C;
PF03951:Gln-synt_N

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 6.3.1.2

# Metabolic_Enzyme_10_GenBank_ID_Protein:
31833

# Metabolic_Enzyme_10_SwissProt_ID:
GLNA_HUMAN (P15104)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
GLUL

# Metabolic_Enzyme_10_Geneatlas_id:
GLUL

# Metabolic_Enzyme_10_hgnc_id:
HGNC:4341

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_10_Gene_Sequence:
>1122 bp
ATGACCACCTCAGCAAGTTCCCACTTAAATAAAGGCATCAAGCAGGTGTACATGTCCCTG
CCTCAGGGTGAGAAAGTCCAGGCCATGTATATCTGGATCGATGGTACTGGAGAAGGACTG
CGCTGCAAGACCCGGACCCTGGACAGTGAGCCCAAGTGTGTGGAAGAGTTGCCTGAGTGG
AATTTCGATGGCTCCAGTACTTTACAGTCTGAGGGTTCCAACAGTGACATGTATCTCGTG
CCTGCTGCCATGTTTCGGGACCCCTTCCGTAAGGACCCTAACAAGCTGGTGTTATGTGAA
GTTTTCAAGTACAATCGAAGGCCTGCAGAGACCAATTTGAGGCACACCTGTAAACGGATA
ATGGACATGGTGAGCAACCAGCACCCCTGGTTTGGCATGGAGCAGGAGTATACCCTCATG
GGGACAGATGGGCACCCCTTTGGTTGGCCTTCCAACGGCTTCCCAGGGCCCCAGGGTCCA
TATTACTGTGGTGTGGGAGCAGACAGAGCCTATGGCAGGGACATCGTGGAGGCCCATTAC
CGGGCCTGCTTGTATGCTGGAGTCAAGATTGCGGGGACTAATGCCGAGGTCATGCCTGCC
CAGTGGGAATTTCAGATTGGACCTTGTGAAGGAATCAGCATGGGAGATCATCTCTGGGTG
GCCCGTTTCATCTTGCATCGTGTGTGTGAAGACTTTGGAGTGATAGCAACCTTTGATCCT
AAGCCCATTCCTGGGAACTGGAATGGTGCAGGCTGCCATACCAACTTCAGCACCAAGGCC
ATGCGGGAGGAGAATGGTCTGAAGTACATCGAGGAGGCCATTGAGAAACTAAGCAAGCGG
CACCAGTACCACATCCGTGCCTATGATCCCAAGGGAGGCCTGGACAATGCCCGACGTCTA
ACTGGATTCCATGAAACCTCCAACATCAACGACTTTTCTGGTGGTGTAGCCAATCGTAGC
GCCAGCATACGCATTCCCCGGACTGTTGGCCAGGAGAAGAAGGGTTACTTTGAAGATCGT
CGCCCCTCTGCCAACTGCGACCCCTTTTCGGTGACAGAAGCCCTCATCCGCACGTGTCTT
CTCAATGAAACCGGCGATGAGCCCTTCCAGTACAAAAATTAA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
Y00387

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_10_Locus:
1q31

# Metabolic_Enzyme_10_SNPs:
rs1058111; rs912900; rs9347; rs912901; rs4075941; rs4652704; rs7539686; rs7734; rs3895340; rs4652705; rs912902; rs12136955; rs12403634; rs4075940; rs1058788; rs16828882; rs8762; rs7543200; rs3795487; rs2296520; rs2296519; rs10494546; rs17462824; rs12735664; rs11577936; rs2296521; rs6691339; rs11577698; rs2296523; rs11577696; rs10797771; rs4652707; rs16858921; rs4652706; rs11585457; rs2296522; rs10429835; rs4517308; rs10797770; rs11541591; rs17855559; rs17852995; rs35378126; rs17852994; rs6666230; rs6684136; rs6679250; rs34809780; rs12082312; rs36115491; rs7548303; rs1058744; rs3199511; rs12757803; rs17509341; rs1058806; rs6703479; rs8527; rs1058719; rs10535077; rs4110992; rs6699943; rs35747237; rs35275813; rs35161314; rs35268520; rs10911069; rs10458354; rs34444584; rs34239448; rs12088820; rs3028837; rs35750497; rs1001403; rs10911070; rs10911071; rs11576932; rs12039934; rs12568730; rs12733426; rs12736387; rs12756106; rs17509572; rs17509621; rs1925829; rs2038891; rs2068781; rs2148030; rs4652708; rs6424853; rs6667958; rs6674281; rs6684297; rs6698722; rs7549329; rs7549498; rs7551829

# Metabolic_Enzyme_10_General_References:
2888076; 1681907; 7909780; 12387715

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5944

# Metabolic_Enzyme_11_Name:
L-serine dehydratase

# Metabolic_Enzyme_11_Synonyms:
L-serine deaminase

# Metabolic_Enzyme_11_Gene_Name:
SDS

# Metabolic_Enzyme_11_Protein_Sequence:
>Lserine dehydratase
MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAHF
VCSSAGNAGMAAAYAARQLGVPATIVVPGTTPALTIERLKNEGATCKVVGELLDEAFELA
KALAKNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEKPGAIALSVGGGGLLCGVVQGL
QECGWGDVPVIAMETFGAHSFHAATTAGKLVSLPKITSVAKALGVKTVGSQALKLFQEHP
IFSEVISDQEAVAAIEKFVDDEKILVEPAWGAALAAVYSHVIQKLQLEGNLRTPLPSLVV
IVCGGSNISLAQLRALKEQLGMTNRLPK

# Metabolic_Enzyme_11_Number_of_Residues:
328

# Metabolic_Enzyme_11_Molecular_Weight:
34703

# Metabolic_Enzyme_11_Theoretical_pI:
8.07

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
L-serine = pyruvate + NH(3)

# Metabolic_Enzyme_11_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00272  Cysteine metabolism

# Metabolic_Enzyme_11_Reaction:
L-serine = pyruvate + NH3

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00291:PALP

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 4.3.1.17

# Metabolic_Enzyme_11_GenBank_ID_Protein:
338030

# Metabolic_Enzyme_11_SwissProt_ID:
SDHL_HUMAN (P20132)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
SDS

# Metabolic_Enzyme_11_Geneatlas_id:
SDS

# Metabolic_Enzyme_11_hgnc_id:
HGNC:10691

# Metabolic_Enzyme_11_PDB_ID:
1P5J

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_11_Gene_Sequence:
>987 bp
ATGATGTCTGGAGAACCCCTGCACGTGAAGACCCCCATCCGTGACAGCATGGCCCTGTCC
AAAATGGCCGGCACCAGCGTCTACCTCAAGATGGACAGTGCCCAGCCCTCCGGCTCCTTC
AAGATCCGGGGCATTGGGCACTTCTGCAAGAGGTGGGCCAAGCAAGGCTGTGCACATTTT
GTCTGCTCCTCGGCGGGCAACGCAGGCATGGCGGCTGCATATGCGGCCAGGCAACTCGGC
GTCCCCGCCACCATCGTAGTGCCCGGCACCACACCTGCTCTCACCATTGAGCGCCTCAAG
AATGAAGGTGCCACATGCAAGGTGGTGGGTGAGTTATTGGATGAAGCCTTCGAGCTGGCC
AAGGCCCTAGCGAAGAACAACCCGGGTTGGGTCTACATTCCCCCCTTTGATGACCCCCTC
ATCTGGGAAGGCCACGCTTCCATCGTGAAAGAGCTGAAGGAGACACTGTGGGAAAAGCCG
GGGGCCATCGCGCTGTCAGTGGGCGGCGGGGGCCTGCTGTGTGGAGTGGTCCAGGGGCTG
CAGGAGTGTGGCTGGGGGGACGTGCCTGTCATCGCCATGGAGACTTTTGGTGCCCACAGC
TTCCACGCTGCCACCACCGCAGGCAAACTTGTCTCCCTGCCCAAGATCACCAGTGTTGCC
AAGGCCCTGGGCGTGAAGACTGTGGGGTCTCAGGCCCTGAAGCTGTTTCAGGAACACCCC
ATTTTCTCTGAAGTTATCTCGGACCAGGAGGCTGTGGCCGCCATTGAGAAGTTCGTGGAT
GATGAGAAGATCCTGGTGGAGCCCGCCTGGGGCGCAGCCCTGGCCGCTGTCTATAGCCAC
GTGATCCAGAAGCTCCAACTGGAGGGGAATCTCCGAACCCCGCTGCCATCCCTCGTGGTC
ATCGTCTGCGGGGGCAGCAACATCAGCCTGGCCCAGCTGCGGGCGCTCAAGGAACAGCTG
GGCATGACAAATAGGTTGCCCAAGTGA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
J05037

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_11_Locus:
12q24.13

# Metabolic_Enzyme_11_SNPs:
rs3812826; rs7960943; rs7980117; rs16942781; rs11609455; rs2069251; rs12820484; rs12832115; rs11829715; rs12833309; rs7135421; rs1050062; rs35465493; rs34607566; rs35638951; rs12306986; rs34954765; rs35429206; rs5800985; rs12824553; rs10624677; rs35911976; rs36075425; rs2303622; rs34218141; rs12824546; rs35764330; rs35270874; rs34219581; rs35190353; rs3794315; rs34550115; rs34835808; rs12766; rs7135290; rs13603; rs34921153; rs34099285; rs7135256; rs7135675; rs12304687; rs34839349; rs35942568; rs11420; rs34969035; rs34862362; rs34014624; rs11066549; rs11066552; rs11066553; rs11831414; rs11832103; rs12425042; rs12812648; rs12815112; rs12818674; rs34803330; rs35106464

# Metabolic_Enzyme_11_General_References:
2674117

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5595

# Metabolic_Enzyme_12_Name:
Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor

# Metabolic_Enzyme_12_Synonyms:
Carbamoyl-phosphate synthetase I; CPSase I

# Metabolic_Enzyme_12_Gene_Name:
CPS1

# Metabolic_Enzyme_12_Protein_Sequence:
>Carbamoylphosphate synthase ammonia, mitochondrial precursor
MTRILTAFKVVRTLKTGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHIVLEDGTKMKGYS
FGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALDELGLSKY
LESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKIIRDKGTML
GKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIRLLVKRGA
EVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGISTGNLIT
GLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNTLPAGWKPLFVNVNDQT
NEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPKPALVASRV
EVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQAD
TVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVES
IMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGIC
PNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHT
GDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLS
RSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDR
FHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEWPSNLDLR
KELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMT
EETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYV
TYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETV
STDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSP
LQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMN
VVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAG
VHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRA
SRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRLRD
ADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPRFLGVAEQ
LHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSIDLVINLPN
NNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQYSAGKAA


# Metabolic_Enzyme_12_Number_of_Residues:
1500

# Metabolic_Enzyme_12_Molecular_Weight:
164941

# Metabolic_Enzyme_12_Theoretical_pI:
6.71

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  carbamoyl-phosphate synthase activity
Function:  catalytic activity
 ||
>>>
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  pyrimidine base metabolism
Process:  pyrimidine base biosynthesis
Process:  urea cycle intermediate metabolism
Process:  arginine metabolism
Process:  arginine biosynthesis
Process:  physiological process
Process:  metabolism
Process:  nitrogen compound metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_12_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_12_Specific_Function:
Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell

# Metabolic_Enzyme_12_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00251  Glutamate metabolism;
 map00330  Arginine and proline metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_12_Reaction:
2 ATP + NH3 + CO2 + H2O = 2 ADP + phosphate + carbamoyl phosphate

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00289:CPSase_L_chain;
PF02786:CPSase_L_D2;
PF02787:CPSase_L_D3;
PF00988:CPSase_sm_chain;
PF00117:GATase;
PF02142:MGS

# Metabolic_Enzyme_12_Signals:
1-19

# Metabolic_Enzyme_12_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 6.3.4.16

# Metabolic_Enzyme_12_GenBank_ID_Protein:
219553

# Metabolic_Enzyme_12_SwissProt_ID:
CPSM_HUMAN (P31327)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
CPS1

# Metabolic_Enzyme_12_Geneatlas_id:
CPS1

# Metabolic_Enzyme_12_hgnc_id:
HGNC:2323

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_12_Gene_Sequence:
>4503 bp
ATGACGAGGATTTTGACAGCTTTCAAAGTGGTGAGGACACTGAAGACTGGTTTTGGCTTT
ACCAATGTGACTGCACACCAAAAATGGAAATTTTCAAGACCTGGCATCAGGCTCCTTTCT
GTCAAGGCACAGACAGCACACATTGTCCTGGAAGATGGAACTAAGATGAAAGGTTACTCC
TTTGGCCATCCATCCTCTGTTGCTGGTGAAGTGGTTTTTAATACTGGCCTGGGAGGGTAC
CCAGAAGCTATTACTGACCCTGCCTACAAAGGACAGATTCTCACAATGGCCAACCCTATT
ATTGGGAATGGTGGAGCTCCTGATACTACTTCTCTGGATGAACTGGGACTTAGCAAATAT
TTGGAGTCTAATGGAATCAAGGTTTCAGGTTTGCTGGTGCTGGATTATAGTAAAGACTAC
AACCACTGGCTGGCTACCAAGAGTTTAGGGCAATGGCTACAGGAAGAAAAGGTTCCTGCA
ATTTATGGAGTGGACACAAGAATGCTGACTAAAATAATTCGGGATAAGGGTACCATGCTT
GGGAAGATTGAATTTGAAGGTCAGCCTGTGGATTTTGTGGATCCAAATAAACAGAATTTG
ATTGCTGAGGTTTCAACCAAGGATGTCAAAGTGTACGGCAAAGGAAACCCCACAAAAGTG
GTAGCTGTAGACTGTGGGATTAAAAACAATGTAATCCGCCTGCTAGTAAAGCGAGGAGCT
GAAGTGCACTTAGTTCCCTGGAACCATGATTTCACCAAGATGGAGTATGATGGGATTTTG
ATCGCGGGAGGACCGGGGAACCCAGCTCTTGCAGAACCACTAATTCAGAATGTTCAGAAG
ATTTTGGAGAGTGATCGCAAGGAGCCATTGTTTGGAATCAGTACAGGAAACTTAATAACA
GGATTGGCTGCTGGTGCCAAAACCTACAAGATGTCCATGGCCAACAGAGGGCAGAATCAG
CCTGTTTTGAATATCACAAACAAACAGGCTTTCATTACTGCTCAGAATCATTGCTATGCC
TTGGACAACACCCTCCCTGCTGGCTGGAAACCACTTTTTGTGAATGTCAACGATCAAACA
AATGAGGGGATTATGCATGAGAGCAAACCCTTCTTCGCTGTGCAGTTCCACCCAGAGGTC
ACCCCGGGGCCAATAGACACTGAGTACCTGTTTGATTCCTTTTTCTCACTGATAAAGAAA
GGAAAAGCTACCACCATTACATCAGTCTTACCGAAGCCAGCACTAGTTGCATCTCGGGTT
GAGGTTTCCAAAGTCCTTATTCTAGGATCAGGAGGTCTGTCCATTGGTCAGGCTGGAGAA
TTTGATTACTCAGGATCTCAAGCTGTAAAAGCCATGAAGGAAGAAAATGTCAAAACTGTT
CTGATGAACCCAAACATTGCATCAGTCCAGACCAATGAGGTGGGCTTAAAGCAAGCGGAT
ACTGTCTACTTTCTTCCCATCACCCCTCAGTTTGTCACAGAGGTCATCAAGGCAGAACAG
CCAGATGGGTTAATTCTGGGCATGGGTGGCCAGACAGCTCTGAACTGTGGAGTAGAACTA
TTCAAGAGAGGTGTGCTCAAGGAATATGGTGTGAAAGTCCTGGGAACTTCAGTTGAGTCC
ATTATGGCTACGGAAGACAGGCAGCTGTTTTCAGATAAACTAAATGAGATCAATGAAAAG
ATTGCTCCAAGTTTTGCAGTGGAATCGATTGAGGATGCACTGAAGGCAGCAGACACCATT
GGCTACCCAGTGATGATCCGTTCCGCCTATGCACTGGGTGGGTTAGGCTCAGGCATCTGT
CCCAACAGAGAGACTTTGATGGACCTCAGCACAAAGGCCTTTGCTATGACCAACCAAATT
CTGGTGGAGAAGTCAGTGACAGGTTGGAAAGAAATAGAATATGAAGTGGTTCGAGATGCT
GATGACAATTGTGTCACTGTCTGTAACATGGAAAATGTTGATGCCATGGGTGTTCACACA
GGTGACTCAGTTGTTGTGGCTCCTGCCCAGACACTCTCCAATGCCGAGTTTCAGATGTTG
AGACGTACTTCAATCAATGTTGTTCGCCACTTGGGCATTGTGGGTGAATGCAACATTCAG
TTTGCCCTTCATCCTACCTCAATGGAATACTGCATCATTGAAGTGAATGCCAAGATGTCC
CCGAACTCTGCTCTGGCCTCCAAAACGACTGGCTACCCATTGGCATTCATTGCTGCAAAG
ATTGCCCTAGGAATCCCACTTCCAGGAATTAAGAACGTCGTATCCGGGAAGACATCAGCC
TGTTTTGAACCTAGCCTGGATTACATGGTCACCAAGATTCCCCGCTGGGATCTTGACCGT
TTTCATGGAACATCTAGCCGAATTGGTAGCTCTATGAAAAGTGTAGGAGAGGTCATGGCT
ATTGGTCGTACCTTTGAGGAGAGTTTCCAGAAAGCTTTACGGATGTGCCACCCATCTATA
GAGGGTTTCACTCCCCGTCTCCCAATGAACAAAGAATGGCCATCGAATTTAGATCTTAGA
AAAGAGTTGTCTGAACCAAGCAGCACGCGTATCTATGCCATTGCCAAGGCCATTGATGAC
AACATGTCCCTTGATGAGATTGAGAAGCTCACATACATTGACAAGTGGTTTTTGTATAAG
ATGCGTGATATTTTAAACATGGAAAAGACACTGAAAGGCCTCAACAGTGAGTCCATGACA
GAAGAAACCCTGAAAAGGGCAAAGGAGATTGGGTTCTCAGATAAGCAGATTTCAAAATGC
CTTGGGCTCACTGAGGCCCAGACAAGGGAGCTGAGGTTAAAGAAAAACATCCACCCTTGG
GTTAAACAGATTGATACACTGGCTGCAGAATACCCATCAGTAACAAACTATCTCTATGTT
ACCTACAATGGTCAGGAGCATGATGTCAATTTTGATGACCATGGAATGATGGTGCTAGGC
TGTGGTCCATATCACATTGGCAGCAGTGTGGAATTTGATTGGTGTGCTGTCTCTAGTATC
CGCACACTGCGTCAACTTGGCAAGAAGACGGTGGTGGTGAATTGCAATCCTGAGACTGTG
AGCACAGACTTTGATGAGTGTGACAAACTGTACTTTGAAGAGTTGTCCTTGGAGAGAATC
CTAGACATCTACCATCAGGAGGCATGTGGTGGCTGCATCATATCAGTTGGAGGCCAGATT
CCAAACAACCTGGCAGTTCCTCTATACAAGAATGGTGTCAAGATCATGGGCACAAGCCCC
CTGCAGATCGACAGGGCTGAGGATCGCTCCATCTTCTCAGCTGTCTTGGATGAGCTGAAG
GTGGCTCAGGCACCTTGGAAAGCTGTTAATACTTTGAATGAAGCACTGGAATTTGCAAAG
TCTGTGGACTACCCCTGCTTGTTGAGGCCTTCCTATGTTTTGAGTGGGTCTGCTATGAAT
GTGGTATTCTCTGAGGATGAGATGAAAAAATTCCTAGAAGAGGCGACTAGAGTTTCTCAG
GCCACGCCAGTGGTGCTGACAAAATTTGTTGAAGGGGCCCGAGAAGTAGAAATGGACGCT
GTTGGCAAAGATGGAAGGGTTATCTCTCATGCCATCTCTGAACATGTTGAAGATGCAGGT
GTCCACTCGGAGAATGCCACTCTGATGCTGCCCACACAAACCATCAGCCAAGGGGCCATT
GAAAAGGTGAAGGATGCTACCCGGAAGATTGCAAAGGCTTTTGCCATCTCTGGTCCATTC
AACGTCCAATTTCTTGTCAAAGGAAATGATGTCTTGGTGAATGAGTGTAACTTGAGAGCT
TCTCGATCCTTCCCCTCTGTTTCCAAGACTCTTGGGGTTGACTTCATTGATGTGGCCACC
AAGGTGTTGATTGGAGAGAATGTTGATGAGAAACATCTTCCAACATTGGACCATCCCATA
ATTCCTGTTGACTATGTTGCAATTAAGGCTCCCATGTTTTCCTGGCCCCGGTTGAGGGAT
GCTGACCCCATTCTGAGATGTGAGATGGCTTCCACTGGAGAGGTGGCTTGCTTTGGTGAA
GGTATTCATACAGCCTTCCTAAAGGCAATGCTTTCCACAGGATTTAAGATACCCCAGAAA
GGCATCCTGATAGGCATCCAGCAATCATTCCGGCCAAGATTCCTTGGTGTGGCTGAACAA
TTACACAATGAAGGTTTCAAGCTGTTTGCCACGGAAGCCACATCAGACTGGCTCAACGCC
AACAATGTCCCTGCCAACCCAGTGGCATGGCCGTCTCAAGAAGGACAGAATCCCAGCCTC
TCTTCCATCAGAAAATTGATTAGAGATGGCAGCATTGACCTAGTGATTAACCTTCCCAAC
AACAACACTAAATTTGTCCATGATAATTATGTGATTCGGAGGACAGCTGTTGATAGTGGA
ATCCCTCTCCTCACTAATTTTCAGGTGACCAAACTTTTTGCTGAAGCTGTGCAGAAATCT
CGCAAGGTGGACTCCAAGAGTCTTTTCCACTACAGGCAGTACAGTGCTGGAAAAGCAGCA
TAG

# Metabolic_Enzyme_12_GenBank_ID_Gene:
D90282

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_12_Locus:
2q35

# Metabolic_Enzyme_12_SNPs:
rs7422339; rs1047883; rs2229589; rs34022862; rs35678745; rs715; rs10932349; rs7684; rs12476133; rs2371001; rs2371013; rs2371000; rs2287598; rs10932348; rs4399666; rs7572146; rs12694205; rs6721477; rs9789405; rs6435577; rs6750325; rs4356603; rs7576225; rs7583733; rs7598448; rs2302910; rs7599931; rs6435580; rs10804185; rs2302911; rs3821135; rs11903254; rs10932343; rs12694206; rs2287603; rs2370998; rs13429886; rs6714124; rs6748782; rs12468557; rs7422569; rs2287596; rs2302908; rs10165443; rs2277909; rs6724941; rs4233981; rs7607412; rs6734696; rs2371002; rs10184633; rs2370997; rs7573258; rs7606346; rs13028752; rs7568329; rs7587791; rs2302909; rs7583822; rs4142154; rs7607205; rs4672587; rs4312427; rs10179039; rs13416810; rs10515951; rs13415932; rs2371009; rs2287602; rs11684318; rs7599172; rs6744672; rs13005552; rs13005394; rs10176085; rs10469763; rs13010668; rs2887914; rs4420657; rs12694201; rs13010236; rs2371010; rs7588072; rs6749137; rs9288418; rs16844777; rs12694202; rs4325692; rs11681045; rs16844779; rs4567871; rs3213785; rs12997383; rs12694204; rs12466705; rs6755648; rs7558276; rs11886625; rs10932347; rs16844773; rs4614865; rs11686101; rs4309518; rs10804186; rs4396646; rs4673543; rs4673539; rs3213784; rs2287604; rs2371007; rs11895303; rs6726148; rs4640325; rs12616596; rs2371011; rs12694203; rs2270476; rs12991680; rs16844647; rs13033773; rs7567836; rs2370996; rs2371003; rs7601962; rs12615486; rs954499; rs16844683; rs7563093; rs16844781; rs12995914; rs17774535; rs10427333; rs7603980; rs16844718; rs6742717; rs6760497; rs11902281; rs7593211; rs7587942; rs10183104; rs13013076; rs10179212; rs16844641; rs17825928; rs7563009; rs17825520; rs33949976; rs13016856; rs2371005; rs13020941; rs10170142; rs16844788; rs951122; rs16844728; rs7606750; rs16844659; rs10211372; rs7575403; rs10932346; rs2287600; rs7598012; rs9752757; rs10191702; rs2371006; rs13391067; rs16844782; rs13416489; rs2371008; rs17773661; rs16844625; rs12990908; rs13401425; rs4363965; rs11889880; rs17832175; rs16844619; rs7587701; rs11897497; rs17824552; rs2302912; rs7575473; rs7580149; rs6743156; rs4673544; rs13399140; rs6754909; rs3770682; rs7582951; rs7575474; rs11685955; rs11680040; rs13383683; rs10180357; rs13022335; rs17775057; rs16844644; rs11685945; rs34222197; rs2887913; rs4142155; rs6749355; rs13388400; rs6749597; rs4433943; rs1047887; rs34656466; rs1129687; rs1047886; rs28940283; rs1129682; rs35374255; rs41272667; rs3835047; rs34778124; rs12475907; rs6728169; rs1048028; rs6743023; rs13017216; rs12996727; rs35985992; rs13409266; rs6435579; rs4257337; rs35940992; rs28429417; rs13385991; rs13429579; rs3217218; rs34201679; rs35410721; rs10195256; rs35896974; rs4673540; rs3214427; rs6720137; rs35440985; rs13414563; rs35586985; rs35809524; rs12992801; rs13431322; rs1060191; rs5838216; rs13031200; rs34987020; rs34054260; rs11902018; rs13429555; rs10427325; rs34903716; rs35104362; rs35072654; rs6717187; rs34665278; rs4673542; rs35548644; rs13393388; rs28469042; rs13024706; rs35354688; rs34484159; rs34713753; rs11269184; rs34922875; rs10182484; rs7607234; rs34394524; rs10525194; rs13408918; rs11315919; rs35970365; rs2270477; rs12988297; rs35299943; rs41272671; rs36066680; rs5838214; rs36093319; rs7568096; rs13035785; rs3217217; rs10715074; rs34542668; rs34056540; rs7562168; rs10203439; rs34919632; rs35523666; rs13017144; rs34134708; rs34869171; rs35129622; rs41272673; rs5838212; rs11372499; rs13432514; rs4989049; rs6704874; rs34800242; rs3213783; rs13017275; rs11321061; rs34710033; rs883542; rs35087298; rs4482415; rs16844626; rs7601865; rs4297818; rs34449727; rs35898556; rs3060402; rs34972394; rs35369959; rs34299015; rs5838213; rs41272669; rs5838215; rs6743099; rs12993913; rs16844749; rs4673541; rs36106186; rs4450537; rs13025458; rs7580590; rs2371012; rs11384554; rs28499505; rs36071800; rs4490117; rs35175269; rs34676314; rs2287597; rs4672585; rs2370999; rs12998821; rs34972928; rs13409263; rs13017341; rs6712334; rs35672393; rs34291327; rs13027714; rs10167325; rs17831707; rs3217219; rs34976026; rs36067265; rs13409110; rs34983401; rs34829607; rs3060429; rs12998416; rs35010546; rs13391585; rs34287343; rs41272665; rs13396451; rs34334217; rs6435578; rs11372498; rs35833900; rs4482413; rs35170724; rs11340188; rs6721139; rs13411696; rs35644063; rs34228696; rs6732642; rs10654573; rs3060397; rs10172081; rs10192215; rs10194936; rs10932345; rs11887861; rs11903219; rs12475210; rs12620917; rs12623361; rs13386028; rs13386056; rs16844800; rs17773128; rs17775871; rs2287599; rs2371014; rs2371015; rs2371017; rs2544304; rs2664230; rs35863145; rs3770683; rs3770684; rs4142151; rs4142152; rs4142153; rs4672588; rs5002316; rs5009272; rs6727826; rs6752652; rs7571548; rs7572869; rs9288420

# Metabolic_Enzyme_12_General_References:
1840546; 9711878; 12955727; 11474210

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5393

# Metabolic_Enzyme_13_Name:
Amine oxidase [flavin-containing] B

# Metabolic_Enzyme_13_Synonyms:
Monoamine oxidase type B; MAO-B

# Metabolic_Enzyme_13_Gene_Name:
MAOB

# Metabolic_Enzyme_13_Protein_Sequence:
>Amine oxidase flavincontaining 
BMSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGS
YVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFW
RTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHE
VSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYID
QTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIV
YYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEE
RLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVD
RIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITT
TFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV

# Metabolic_Enzyme_13_Number_of_Residues:
520

# Metabolic_Enzyme_13_Molecular_Weight:
58764

# Metabolic_Enzyme_13_Theoretical_pI:
7.55

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_13_Specific_Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine

# Metabolic_Enzyme_13_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_13_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF01593:Amino_oxidase

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
490-516

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 1.4.3.4

# Metabolic_Enzyme_13_GenBank_ID_Protein:
398415

# Metabolic_Enzyme_13_SwissProt_ID:
AOFB_HUMAN (P27338)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
MAOB

# Metabolic_Enzyme_13_Geneatlas_id:
MAOB

# Metabolic_Enzyme_13_hgnc_id:
HGNC:6834

# Metabolic_Enzyme_13_PDB_ID:
2BK3

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type IV membrane protein; cytoplasmic side

# Metabolic_Enzyme_13_Gene_Sequence:
>1560 bp
ATGAGCAACAAATGCGACGTGGTCGTGGTGGGGGGCGGCATCTCAGGTATGGCAGCAGCC
AAACTTCTGCATGACTCTGGACTGAATGTGGTTGTTCTGGAAGCCCGGGACCGTGTGGGA
GGCAGGACTTACACTCTTAGGAACCAAAAGGTTAAATATGTGGACCTTGGAGGATCCTAT
GTTGGACCAACCCAGAATCGTATCTTGAGATTAGCCAAGGAGCTAGGATTGGAGACCTAC
AAAGTGAATGAGGTTGAGCGTCTGATCCACCATGTAAAGGGCAAATCATACCCCTTCAGG
GGGCCATTCCCACCTGTATGGAATCCAATTACCTACTTAGATCATAACAACTTTTGGAGG
ACAATGGATGACATGGGGCGAGAGATTCCGAGTGATGCCCCATGGAAGGCTCCCCTTGCA
GAAGAGTGGGACAACATGACAATGAAGGAGCTACTGGACAAGCTCTGCTGGACTGAATCT
GCAAAGCAGCTTGCCACTCTCTTTGTGAACCTGTGTGTCACTGCAGAGACCCATGAGGTC
TCTGCTCTCTGGTTCCTGTGGTATGTGAAGCAGTGTGGAGGCACAACAAGAATCATCTCG
ACAACAAATGGAGGACAGGAGAGGAAATTTGTGGGCGGATCTGGTCAAGTGAGTGAGCGG
ATAATGGACCTCCTTGGAGACCGAGTGAAGCTGGAGAGGCCTGTGATCTACATTGACCAG
ACAAGAGAAAATGTCCTTGTGGAGACCCTAAACCATGAGATGTATGAGGCTAAATATGTG
ATTAGTGCTATTCCTCCTACTCTGGGCATGAAGATTCACTTCAATCCCCCTCTGCCAATG
ATGAGAAACCAGATGATCACTCGTGTGCCTTTGGGTTCAGTCATCAAGTGTATAGTTTAT
TATAAAGAGCCTTTCTGGAGGAAAAAGGATTACTGTGGAACCATGATTATTGATGGAGAA
GAAGCTCCAGTTGCCTACACGTTGGATGATACCAAACCTGAAGGCAACTATGCTGCCATA
ATGGGATTTATCCTGGCCCACAAAGCCAGAAAACTGGCACGTCTTACCAAAGAGGAAAGG
TTGAAGAAACTTTGTGAACTCTATGCCAAGGTTCTGGGTTCCCTAGAAGCTCTGGAGCCA
GTGCATTATGAAGAAAAGAACTGGTGTGAGGAGCAGTACTCTGGGGGCTGCTACACAACT
TATTTCCCCCCTGGGATCCTGACTCAATATGGAAGGGTTCTACGCCAGCCAGTGGACAGG
ATTTACTTTGCAGGCACCGAGACTGCCACACACTGGAGCGGCTACATGGAGGGGGCTGTA
GAGGCCGGGGAGAGAGCAGCCCGAGAGATCCTGCATGCCATGGGGAAGATTCCAGAGGAT
GAAATCTGGCAGTCAGAACCAGAGTCTGTGGATGTCCCTGCACAGCCCATCACCACCACC
TTTTTGGAGAGACATTTGCCCTCCGTGCCAGGCCTGCTCAGGCTGATTGGATTGACCACC
ATCTTTTCAGCAACGGCTCTTGGCTTCCTGGCCCACAAAAGGGGGCTACTTGTGAGAGTC


# Metabolic_Enzyme_13_GenBank_ID_Gene:
S62734

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_13_Locus:
Xp11.23

# Metabolic_Enzyme_13_SNPs:
rs7879356; rs6324; rs12010260; rs2072745; rs17462; rs3027440; rs7066677; rs3027439; rs1799836; rs3027453; rs2311013; rs3027441; rs5905512; rs3027459; rs2239450; rs2239441; rs7890174; rs5952297; rs3027444; rs5952330; rs7883073; rs5952671; rs6520902; rs2239449; rs6651806; rs3027454; rs7057075; rs12394221; rs2238969; rs12008119; rs7888450; rs12388038; rs2283727; rs12013965; rs17310637; rs12008438; rs5952294; rs5952340; rs12008548; rs12014398; rs1014876; rs3027449; rs2283730; rs2283729; rs5952813; rs6520901; rs5952352; rs2205655; rs10521432; rs6610856; rs12006628; rs3027450; rs6610853; rs2283731; rs3027456; rs2283728; rs9887326; rs5952325; rs3027442; rs7879586; rs12389168; rs3817729; rs12851487; rs5952686; rs3736672; rs2056913; rs1569424; rs7053203; rs2092042; rs7876594; rs12010996; rs3027457; rs9887047; rs3027451; rs17146716; rs7061798; rs3027464; rs6609259; rs3027446; rs736944; rs2239442; rs6609260; rs7067187; rs3027466; rs12558324; rs7888462; rs3027452; rs2092040; rs4824562; rs17146721; rs7884044; rs3027461; rs12389234; rs12007768; rs17244906; rs5952795; rs17146719; rs5905449; rs5952799; rs12394863; rs3027458; rs3027443; rs9698576; rs2092041; rs7892217; rs7061088; rs12689868; rs7067027; rs3027448; rs12558614; rs7057957; rs1040398; rs1040400; rs3027435; rs1181252; rs1040399; rs3027434; rs17852046; rs12850496; rs12845773; rs17856663; rs12845783; rs5952696; rs3191382; rs1181251; rs35285191; rs1051000; rs1803940; rs3027438; rs1051003; rs1050990; rs4339787; rs28530533; rs3027468; rs5952754; rs5952690; rs12558961; rs12852985; rs34468176; rs2311012; rs5905428; rs34165496; rs34825602; rs7892394; rs5952812; rs11091124; rs5906017; rs28522648; rs5952677; rs11282093; rs5906045; rs3838196; rs3027455; rs28667959; rs3027463; rs35676271; rs12841775; rs35574902; rs3027447; rs28657720; rs6610848; rs28531879; rs4824563; rs6610854; rs7060566; rs12396954; rs3027469; rs35687186; rs5952736; rs35375952; rs7057164; rs34716997; rs7062993; rs7063171; rs11412800; rs6651629; rs12845848; rs12853563; rs12012179; rs28368734; rs12115950; rs35968321; rs3027460; rs12394356; rs35439218; rs36085366; rs34265248; rs35762562; rs2239451; rs34292051; rs3027445; rs11320541; rs10481834; rs12845568; rs4592179; rs3216388; rs34945383; rs34220802; rs6610855; rs34261731; rs28485908; rs7888867; rs11431011; rs4071606; rs12390352; rs10567219; rs35520175; rs28527225; rs36068670; rs5952687; rs7888857; rs5952777; rs34822523; rs12010683; rs7883563; rs5952814; rs36209687; rs5952751; rs2238970; rs5952744; rs35797631; rs12389578; rs7474005; rs3027465; rs5952768; rs5906031; rs28636832; rs34252524; rs7058426; rs12391346; rs12689072; rs35943983; rs12395246; rs11414517; rs3027467; rs12013925; rs3736671; rs28421767; rs7058949; rs35634965; rs28754429; rs1894610; rs36102775; rs9887081; rs5952817; rs12855578; rs10658111; rs7062575; rs4620438; rs28568938; rs35291347; rs11797733; rs35054600; rs5952335; rs3027462; rs5952712; rs34752122; rs3054011; rs3027437; rs28577261; rs3027433; rs3761584; rs3027436; rs3027432; rs12558036; rs3027418; rs3027419; rs3027420; rs3027421; rs3027423; rs3027424; rs3027425; rs3027426; rs3027427; rs3027428; rs3027429; rs3027430; rs3027431; rs4351544; rs7884135; rs7890899

# Metabolic_Enzyme_13_General_References:
2023912; 3387449; 8515265; 1432104; 11049757; 11753429

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5401

# Metabolic_Enzyme_14_Name:
Amine oxidase [flavin-containing] A

# Metabolic_Enzyme_14_Synonyms:
Monoamine oxidase type A; MAO-A

# Metabolic_Enzyme_14_Gene_Name:
MAOA

# Metabolic_Enzyme_14_Protein_Sequence:
>Amine oxidase flavincontaining 
AMENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEH
VDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPI
AYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVN
INVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVK
LNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLP
MGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKAD
RLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQY
GRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESK
DVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS

# Metabolic_Enzyme_14_Number_of_Residues:
527

# Metabolic_Enzyme_14_Molecular_Weight:
59682

# Metabolic_Enzyme_14_Theoretical_pI:
7.96

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine

# Metabolic_Enzyme_14_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_14_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF01593:Amino_oxidase

# Metabolic_Enzyme_14_Signals:
None

# Metabolic_Enzyme_14_Transmembrane_Regions:
498-518

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 1.4.3.4

# Metabolic_Enzyme_14_GenBank_ID_Protein:
187353

# Metabolic_Enzyme_14_SwissProt_ID:
AOFA_HUMAN (P21397)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
MAOA

# Metabolic_Enzyme_14_Geneatlas_id:
MAOA

# Metabolic_Enzyme_14_hgnc_id:
HGNC:6833

# Metabolic_Enzyme_14_PDB_ID:
1O5W

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type IV membrane protein; cytoplasmic side

# Metabolic_Enzyme_14_Gene_Sequence:
>1584 bp
ATGGAGAATCAAGAGAAGGCGAGTATCGCGGGCCACATGTTCGACGTAGTCGTGATCGGA
GGTGGCATTTCAGGACTATCTGCTGCCAAACTCTTGACTGAATATGGCGTTAGTGTTTTG
GTTTTAGAAGCTCGGGACAGGGTTGGAGGAAGAACATATACTATAAGGAATGAGCATGTT
GATTACGTAGATGTTGGTGGAGCTTATGTGGGACCAACCCAAAACAGAATCTTACGCTTG
TCTAAGGAGCTGGGCATAGAGACTTACAAAGTGAATGTCAGTGAGCGTCTCGTTCAATAT
GTCAAGGGGAAAACATATCCATTTCGGGGCGCCTTTCCACCAGTATGGAATCCCATTGCA
TATTTGGATTACAATAATCTGTGGAGGACAATAGATAACATGGGGAAGGAGATTCCAACT
GATGCACCCTGGGAGGCTCAACATGCTGACAAATGGGACAAAATGACCATGAAAGAGCTC
ATTGACAAAATCTGCTGGACAAAGACTGCTAGGCGGTTTGCTTATCTTTTTGTGAATATC
AATGTGACCTCTGAGCCTCACGAAGTGTCTGCCCTGTGGTTCTTGTGGTATGTGAAGCAG
TGCGGGGGCACCACTCGGATATTCTCTGTCACCAATGGTGGCCAGGAACGGAAGTTTGTA
GGTGGATCTGGTCAAGTGAGCGAACGGATAATGGACCTCCTCGGAGACCAAGTGAAGCTG
AACCATCCTGTCACTCACGTTGACCAGTCAAGTGACAACATCATCATAGAGACGCTGAAC
CATGAACATTATGAGTGCAAATACGTAATTAATGCGATCCCTCCGACCTTGACTGCCAAG
ATTCACTTCAGACCAGAGCTTCCAGCAGAGAGAAACCAGTTAATTCAGCGGCTTCCAATG
GGAGCTGTCATTAAGTGCATGATGTATTACAAGGAGGCCTTCTGGAAGAAGAAGGATTAC
TGTGGCTGCATGATCATTGAAGATGAAGATGCTCCAATTTCAATAACCTTGGATGACACC
AAGCCTGATGGGTCACTGCCTGCCATCATGGGCTTCATTCTTGCCCGGAAAGCTGATCGA
CTTGCTAAGCTACATAAGGAAATAAGGAAGAAGAAAATCTGTGAGCTCTATGCCAAAGTG
CTGGGATCCCAAGAAGCTTTACATCCAGTGCATTATGAAGAGAAGAACTGGTGTGAGGAG
CAGTACTCTGGGGGCTGCTACACGGCCTACTTCCCTCCTGGGATCATGACTCAATATGGA
AGGGTGATTCGTCAACCCGTGGGCAGGATTTTCTTTGCGGGCACAGAGACTGCCACAAAG
TGGAGCGGCTACATGGAAGGGGCAGTTGAGGCTGGAGAACGAGCAGCTAGGGAGGTCTTA
AATGGTCTCGGGAAGGTGACCGAGAAAGATATCTGGGTACAAGAACCTGAATCAAAGGAC
GTTCCAGCGGTAGAAATCACCCACACCTTCTGGGAAAGGAACCTGCCCTCTGTTTCTGGC
CTGCTGAAGATCATTGGATTTTCCACATCAGTAACTGCCCTGGGGTTTGTGCTGTACAAA
TACAAGCTCCTGCCACGGTCTTGA

# Metabolic_Enzyme_14_GenBank_ID_Gene:
M68840

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_14_Locus:
Xp11.3

# Metabolic_Enzyme_14_SNPs:
rs6323; rs1137070; rs1800464; rs3027407; rs2072743; rs1465107; rs979605; rs3027397; rs2205718; rs979606; rs909525; rs3788862; rs2283725; rs2235186; rs5906883; rs5906974; rs3027403; rs3027405; rs6520894; rs3027401; rs3788863; rs2235185; rs1465108; rs5953385; rs2310883; rs6609250; rs3027398; rs5906938; rs5906729; rs6520897; rs5906893; rs17146683; rs7885398; rs3027402; rs5905702; rs5906957; rs2072744; rs5906915; rs4824498; rs9723729; rs3027406; rs5906973; rs3027400; rs2064697; rs5906914; rs5906901; rs12689575; rs2239448; rs2064696; rs3027392; rs2238968; rs17146660; rs12688067; rs9723711; rs7051042; rs5905859; rs7887158; rs2064698; rs7882699; rs3027399; rs9330645; rs2283724; rs9723795; rs3027404; rs9724332; rs5953210; rs1803986; rs1799835; rs1800466; rs1803987; rs1800465; rs7065428; rs3027408; rs11544798; rs12839550; rs10545588; rs5952250; rs3027394; rs34390290; rs1800659; rs10560402; rs12854463; rs35759188; rs28375424; rs7059300; rs12687961; rs35784967; rs35254233; rs34894015; rs35215664; rs35546327; rs3027396; rs12556694; rs7057038; rs12687974; rs9780693; rs7892282; rs5902323; rs28593700; rs35600375; rs35488042; rs35200424; rs5902326; rs5905823; rs12843650; rs34941362; rs34841794; rs12833632; rs12863636; rs3030071; rs12398290; rs10548364; rs28401570; rs4604608; rs28449781; rs6609256; rs6610845; rs12833929; rs12843268; rs2310884; rs5905830; rs6610846; rs7054032; rs7880230; rs41303697; rs3810709; rs2179098; rs12399572; rs12840448; rs5902324; rs28556796; rs5905812; rs12847449; rs28619059; rs10652560; rs6610837; rs10548363; rs5905418; rs2283726; rs33910552; rs3027395; rs28637527; rs5906971; rs28439389; rs35235270; rs3027393; rs28583596; rs6610842; rs6520893; rs35336176; rs5906913; rs12849959; rs36036121; rs5905822; rs5902325; rs5905809; rs11471949; rs6610834; rs3838195; rs3216387; rs33946653; rs6609255; rs35445276; rs7061874; rs17436054; rs1181275; rs12843533; rs2064070; rs3027409; rs3027410; rs3027414; rs3027415; rs3027416; rs3027417; rs4301558; rs4570308; rs5905613; rs6609257; rs6609258; rs7052785; rs727884

# Metabolic_Enzyme_14_General_References:
3418353; 3387449; 1432104; 8584674; 7519662; 3178846; 2764901; 11812236

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5945

# Metabolic_Enzyme_15_Name:
Coagulation factor XIII A chain precursor

# Metabolic_Enzyme_15_Synonyms:
Coagulation factor XIIIa; Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain

# Metabolic_Enzyme_15_Gene_Name:
F13A1

# Metabolic_Enzyme_15_Protein_Sequence:
>Coagulation factor XIII A chain precursor
MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDT
NKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPV
PIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETD
TYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCL
YVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDIL
LEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGN
VNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKH
GHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITD
TYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITF
RNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLL
EQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVQFTNPLKET
LRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYG
ELDVQIQRRPSM

# Metabolic_Enzyme_15_Number_of_Residues:
732

# Metabolic_Enzyme_15_Molecular_Weight:
83268

# Metabolic_Enzyme_15_Theoretical_pI:
5.95

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  peptide cross-linking
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Not Available

# Metabolic_Enzyme_15_Specific_Function:
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin

# Metabolic_Enzyme_15_Pathway:
Not Available

# Metabolic_Enzyme_15_Reaction:
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00927:Transglut_C;
PF01841:Transglut_core;
PF00868:Transglut_N

# Metabolic_Enzyme_15_Signals:
None

# Metabolic_Enzyme_15_Transmembrane_Regions:
None

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 2.3.2.13

# Metabolic_Enzyme_15_GenBank_ID_Protein:
182309

# Metabolic_Enzyme_15_SwissProt_ID:
F13A_HUMAN (P00488)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
F13A1

# Metabolic_Enzyme_15_Geneatlas_id:
F13A1

# Metabolic_Enzyme_15_hgnc_id:
HGNC:3531

# Metabolic_Enzyme_15_PDB_ID:
1FIE

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Cytoplasm. Secreted protein. Note=Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma

# Metabolic_Enzyme_15_Gene_Sequence:
>2199 bp
ATGTCAGAAACTTCCAGGACCGCCTTTGGAGGCAGAAGAGCAGTTCCACCCAATAACTCT
AATGCAGCGGAAGATGACCTGCCCACAGTGGAGCTTCAGGGCGTGGTGCCCCGGGGCGTC
AACCTGCAAGAGTTTCTTAATGTCACGAGCGTTCACCTGTTCAAGGAGAGATGGGACACT
AACAAGGTGGACCACCACACTGACAAGTATGAAAACAACAAGCTGATTGTCCGCAGAGGG
CAGTCTTTCTATGTGCAGATTGACTTCAGTCGTCCATATGACCCCAGAAGGGATCTCTTC
AGGGTGGAATACGTCATTGGTCGCTACCCACAGGAGAACAAGGGAACCTACATCCCAGTG
CCTATAGTCTCAGAGTTACAAAGTGGAAAGTGGGGGGCCAAGATTGTCATGAGAGAGGAC
AGGTCTGTGCGGCTGTCCATCCAGTCTTCCCCCAAATGTATTGTGGGGAAATTCCGCATG
TATGTTGCTGTCTGGACTCCCTATGGCGTACTTCGAACCAGTCGAAACCCAGAAACAGAC
ACGTACATTCTCTTCAATCCTTGGTGTGAAGATGATGCTGTGTATCTGGACAATGAGAAA
GAAAGAGAAGAGTATGTCCTGAATGACATCGGGGTAATTTTTTATGGAGAGGTCAATGAC
ATCAAGACCAGAAGCTGGAGCTATGGTCAGTTTGAAGATGGCATCCTGGACACTTGCCTG
TATGTGATGGACAGAGCACAAATGGACCTCTCTGGAAGAGGGAATCCCATCAAAGTCAGC
CGTGTGGGGTCTGCAATGGTGAATGCCAAAGATGACGAAGGTGTCCTCGTTGGATCCTGG
GACAATATCTATGCCTATGGCGTCCCCCCATCGGCCTGGACTGGAAGCGTTGACATTCTA
TTGGAATACCGGAGCTCTGAGAATCCAGTCCGGTATGGCCAATGCTGGGTTTTTGCTGGT
GTCTTTAACACATTTTTACGATGCCTTGGAATACCAGCAAGAATTGTTACCAATTATTTC
TCTGCCCATGATAATGATGCCAATTTGCAAATGGACATCTTCCTGGAAGAAGATGGGAAC
GTGAATTCCAAACTCACCAAGGATTCAGTGTGGAACTACCACTGCTGGAATGAAGCATGG
ATGACAAGGCCTGACCTTCCTGTTGGATTTGGAGGCTGGCAAGCTGTGGACAGCACCCCC
CAGGAAAATAGCGATGGCATGTATCGGTGTGGCCCCGCCTCGGTTCAAGCCATCAAGCAC
GGCCATGTCTGCTTCCAATTTGATGCACCTTTTGTTTTTGCAGAGGTCAACAGCGACCTC
ATTTACATTACAGCTAAGAAAGATGGCACTCATGTGGTGGAAAATGTGGATGCCACCCAC
ATTGGGAAATTAATTGTGACCAAACAAATTGGAGGAGATGGCATGATGGATATTACTGAT
ACTTACAAATTCCAAGAAGGTCAAGAAGAAGAGAGATTGGCCCTAGAAACTGCCCTGATG
TACGGAGCTAAAAAGCCCCTCAACACAGAAGGTGTCATGAAATCAAGGTCCAACGTTGAC
ATGGACTTTGAAGTGGAAAATGCTGTGCTGGGAAAAGACTTCAAGCTCTCCATCACCTTC
CGGAACAACAGCCACAACCGTTACACCATCACAGCTTATCTCTCAGCCAACATCACCTTC
TACACCGGGGTCCTGAAGGCAGAATTCAAGAAGGAGACGTTCGACGTGACGCTGGAGCCC
TTGTCCTTCAAGAAAGAGGCGGTGCTGATCCAAGCCGGCGAGTACATGGGTCAGCTGCTG
GAACAAGCGTCCCTGCACTTCTTTGTCACAGCTCGCATCAATGAGACCAGGGATGTTCTG
GCCAAGCAAAAGTCCACCGTGCTAACCATCCCTGAGATCATCATCAAGGTCCGTGGCACT
CAGGTAGTTGGTTCTGACATGACTGTGACAGTTCAGTTTACCAATCCTTTAAAAGAAACC
CTGCGAAATGTCTGGGTACACCTGGATGGTCCTGGAGTAACAAGACCAATGAAGAAGATG
TTCCGTGAAATCCGGCCCAACTCCACCGTGCAGTGGGAAGAAGTGTGCCGGCCCTGGGTC
TCTGGGCATCGGAAGCTGATAGCCAGCATGAGCAGTGACTCCCTGAGACATGTGTATGGC
GAGCTGGACGTGCAGATTCAAAGACGACCTTCCATGTGA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
M22001

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_15_Locus:
6p25.3-p24.3

# Metabolic_Enzyme_15_SNPs:
Not Available

# Metabolic_Enzyme_15_General_References:
2901091; 3026437; 2877457; 2877456; 4811064; 7913750; 7660355; 9515726; 9988734; 7913909; 1353995; 9763561; 10391209

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5946

# Metabolic_Enzyme_16_Name:
Protein-arginine deiminase type-4

# Metabolic_Enzyme_16_Synonyms:
Protein-arginine deiminase type IV; Peptidylarginine deiminase IV; HL-60 PAD

# Metabolic_Enzyme_16_Gene_Name:
PADI4

# Metabolic_Enzyme_16_Protein_Sequence:
>Proteinarginine deiminase type4
MAQGTLIRVTPEQPTHAVCVLGTLTQLDICSSAPEDCTSFSINASPGVVVDIAHSPPAKK
KSTGSSTWPLDPGVEVTLTMKAASGSTGDQKVQISYYGPKTPPVKALLYLTAVEISLCAD
ITRTGKVKPTRAVKDQRTWTWGPCGQGAILLVNCDRDNLESSAMDCEDDEVLDSEDLQDM
SLMTLSTKTPKDFFTNHTLVLHVARSEMDKVRVFQATRGKLSSKCSVVLGPKWPSHYLMV
PGGKHNMDFYVEALAFPDTDFPGLITLTISLLDTSNLELPEAVVFQDSVVFRVAPWIMTP
NTQPPQEVYACSIFENEDFLKSVTTLAMKAKCKLTICPEEENMDDQWMQDEMEIGYIQAP
HKTLPVVFDSPRNRGLKEFPIKRVMGPDFGYVTRGPQTGGISGLDSFGNLEVSPPVTVRG
KEYPLGRILFGDSCYPSNDSRQMHQALQDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVP
APDRKGFRLLLASPRSCYKLFQEQQNEGHGEALLFEGIKKKKQQKIKNILSNKTLREHNS
FVERCIDWNRELLKRELGLAESDIIDIPQLFKLKEFSKAEAFFPNMVNMLVLGKHLGIPK
PFGPVINGRCCLEEKVCSLLEPLGLQCTFINDFFTYHIRHGEVHCGTNVRRKPFSFKWWN
MVP

# Metabolic_Enzyme_16_Number_of_Residues:
663

# Metabolic_Enzyme_16_Molecular_Weight:
74096

# Metabolic_Enzyme_16_Theoretical_pI:
6.56

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Function:  protein-arginine deiminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Not Available

# Metabolic_Enzyme_16_Specific_Function:
Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1

# Metabolic_Enzyme_16_Pathway:
Not Available

# Metabolic_Enzyme_16_Reaction:
protein L-arginine + H2O = protein L-citrulline + NH3

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF03068:PAD;
PF08527:PAD_M;
PF08526:PAD_N

# Metabolic_Enzyme_16_Signals:
None

# Metabolic_Enzyme_16_Transmembrane_Regions:
None

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 3.5.3.15

# Metabolic_Enzyme_16_GenBank_ID_Protein:
5913971

# Metabolic_Enzyme_16_SwissProt_ID:
PADI4_HUMAN (Q9UM07)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
PADI4

# Metabolic_Enzyme_16_Geneatlas_id:
PADI4

# Metabolic_Enzyme_16_hgnc_id:
HGNC:18368

# Metabolic_Enzyme_16_PDB_ID:
1WD8

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Cytoplasm. Nucleus. Note=Cytoplasmic granules of eosinophils and neutrophils

# Metabolic_Enzyme_16_Gene_Sequence:
>1992 bp
ATGGCCCAGGGGACATTGATCCGTGTGACCCCAGAGCAGCCCACCCATGCCGTGTGTGTG
CTGGGCACCTTGACTCAGCTTGACATCTGCAGCTCTGCCCCTGAGGACTGCACGTCCTTC
AGCATCAACGCCTCCCCAGGGGTGGTCGTGGATATTGCCCACAGCCCTCCAGCCAAGAAG
AAATCCACAGGTTCCTCCACATGGCCCCTGGACCCTGGGGTAGAGGTGACCCTGACGATG
AAAGCGGCCAGTGGTAGCACAGGCGACCAGAAGGTTCAGATTTCATACTACGGACCCAAG
ACTCCACCAGTCAAAGCTCTACTCTACCTCACCGCGGTGGAAATCTCCCTGTGCGCAGAC
ATCACCCGCACCGGCAAAGTGAAGCCAACCAGAGCTGTGAAAGATCAGAGGACCTGGACC
TGGGGCCCTTGTGGACAGGGTGCCATCCTGCTGGTGAACTGTGACAGAGACAATCTCGAA
TCTTCTGCCATGGACTGCGAGGATGATGAAGTGCTTGACAGCGAAGACCTGCAGGACATG
TCGCTGATGACCCTGAGCACGAAGACCCCCAAGGACTTCTTCACAAACCATACACTGGTG
CTCCACGTGGCCAGGTCTGAGATGGACAAAGTGAGGGTGTTTCAGGCCACACGGGGCAAA
CTGTCCTCCAAGTGCAGCGTAGTCTTGGGTCCCAAGTGGCCCTCTCACTACCTGATGGTC
CCCGGTGGAAAGCACAACATGGACTTCTACGTGGAGGCCCTCGCTTTCCCGGACACCGAC
TTCCCGGGGCTCATTACCCTCACCATCTCCCTGCTGGACACGTCCAACCTGGAGCTCCCC
GAGGCTGTGGTGTTCCAAGACAGCGTGGTCTTCCGCGTGGCGCCCTGGATCATGACCCCC
AACACCCAGCCCCCGCAGGAGGTGTACGCGTGCAGTATTTTTGAAAATGAGGACTTCCTG
AAGTCAGTGACTACTCTGGCCATGAAAGCCAAGTGCAAGCTGACCATCTGCCCTGAGGAG
GAGAACATGGATGACCAGTGGATGCAGGATGAAATGGAGATCGGCTACATCCAAGCCCCA
CACAAAACGCTGCCCGTGGTCTTCGACTCTCCAAGGAACAGAGGCCTGAAGGAGTTTCCC
ATCAAACGAGTGATGGGTCCAGATTTTGGCTATGTAACTCGAGGGCCCCAAACAGGGGGT
ATCAGTGGACTGGACTCCTTTGGGAACCTGGAAGTGAGCCCCCCAGTCACAGTCAGGGGC
AAGGAATACCCGCTGGGCAGGATTCTCTTCGGGGACAGCTGTTATCCCAGCAATGACAGC
CGGCAGATGCACCAGGCCCTGCAGGACTTCCTCAGTGCCCAGCAGGTGCAGGCCCCTGTG
AAGCTCTATTCTGACTGGCTGTCCGTGGGCCACGTGGACGAGTTCCTGAGCTTTGTGCCA
GCACCCGACAGGAAGGGCTTCCGGCTGCTCCTGGCCAGCCCCAGGTCCTGCTACAAACTG
TTCCAGGAGCAGCAGAATGAGGGCCACGGGGAGGCCCTGCTGTTCGAAGGGATCAAGAAA
AAAAAACAGCAGAAAATAAAGAACATTCTGTCAAACAAGACATTGAGAGAACATAATTCA
TTTGTGGAGAGATGCATCGACTGGAACCGCGAGCTGCTGAAGCGGGAGCTGGGCCTGGCC
GAGAGTGACATCATTGACATCCCGCAGCTCTTCAAGCTCAAAGAGTTCTCTAAGGCGGAA
GCTTTTTTCCCCAACATGGTGAACATGCTGGTGCTAGGGAAGCACCTGGGCATCCCCAAG
CCCTTCGGGCCCGTCATCAACGGCCGCTGCTGCCTGGAGGAGAAGGTGTGTTCCCTGCTG
GAGCCACTGGGCCTCCAGTGCACCTTCATCAACGACTTCTTCACCTACCACATCAGGCAT
GGGGAGGTGCACTGCGGCACCAACGTGCGCAGAAAGCCCTTCTCCTTCAAGTGGTGGAAC
ATGGTGCCCTGA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
AB017919

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_16_Locus:
1p36.13

# Metabolic_Enzyme_16_SNPs:
rs1748020; rs11588132; rs11203366; rs11203367; rs874881; rs35809521; rs35381732; rs35903413; rs33981382; rs12733102; rs16825565; rs1748033; rs2240335; rs2301887; rs2477152; rs1635561; rs2501806; rs1635580; rs2147333; rs2240336; rs2477131; rs1635571; rs1635594; rs1548323; rs2240337; rs1748031; rs1621005; rs11203354; rs766449; rs2147332; rs6673715; rs1886301; rs1635597; rs1748035; rs942460; rs882537; rs4920591; rs10888018; rs6673392; rs1748032; rs1924552; rs1748034; rs1635577; rs1555658; rs3795214; rs4920594; rs1886302; rs10788664; rs874882; rs1635565; rs1204895; rs1408424; rs1635586; rs1359303; rs1635592; rs1748038; rs4506507; rs7534455; rs2477129; rs6586526; rs11581515; rs2240338; rs12754590; rs10888017; rs1748028; rs12030939; rs1635583; rs1748015; rs4920600; rs1635584; rs1635567; rs1635579; rs10888020; rs10788662; rs2428736; rs11203359; rs6586520; rs11203360; rs3795213; rs1635593; rs1612843; rs2501808; rs1635590; rs2301888; rs2428735; rs10888023; rs11585797; rs4450060; rs2501801; rs1635578; rs1886300; rs1748030; rs12033604; rs1613229; rs1748021; rs11578027; rs16825533; rs1748039; rs1635591; rs2501804; rs11203361; rs4920601; rs10888019; rs1635596; rs1748027; rs6683201; rs11203358; rs1635570; rs1748029; rs10888024; rs11203368; rs1635564; rs2240339; rs4920598; rs6692262; rs4920592; rs1957879; rs1635574; rs1748025; rs11203370; rs1957880; rs10888021; rs1748022; rs1748041; rs1748014; rs1748036; rs4345840; rs12136589; rs7417937; rs2240340; rs3094881; rs2501799; rs12408893; rs11203363; rs6683037; rs11585594; rs3094882; rs4920363; rs1635576; rs12124732; rs1748011; rs12758919; rs12746451; rs11203356; rs4920597; rs1635599; rs11203362; rs11587827; rs1635569; rs1613767; rs10788666; rs1748023; rs1957878; rs12752914; rs6662651; rs9970772; rs12731545; rs4920595; rs10788665; rs6686220; rs1748010; rs1635589; rs11203369; rs4920368; rs11803423; rs12757498; rs1635595; rs12746252; rs11203371; rs1635587; rs10788663; rs10888022; rs6673924; rs12035527; rs1635566; rs1748040; rs4920593; rs13375202; rs1204893; rs12045971; rs12035646; rs1635598; rs6687815; rs2352842; rs1635585; rs1748013; rs2501803; rs11583124; rs11203364; rs2477130; rs1204894; rs12741565; rs2501798; rs4920596; rs34481461; rs11203365; rs12074670; rs2501800; rs6686575; rs12037914; rs12754450; rs1957881; rs1635581; rs10749618; rs12739518; rs1748012; rs2501807; rs11576537; rs1635588; rs16825849; rs11203357; rs3795212; rs1748019; rs11586805; rs12725408; rs4920370; rs11203355; rs1408422; rs11579504; rs2501795; rs1408423; rs2477134; rs2477133; rs2501796; rs2501797; rs34743635; rs34309058; rs41265997; rs41265995; rs17852287; rs2301886; rs35240185; rs34954650; rs28615821; rs35598859; rs35489932; rs12730340; rs34915552; rs34438787; rs35921803; rs12131500; rs7554069; rs7546502; rs35758312; rs34160027; rs4920366; rs4920367; rs34016518; rs12082954; rs1748017; rs2501802; rs12752201; rs34170018; rs12083954; rs12568981; rs34916684; rs12731357; rs10716965; rs11378800; rs12083961; rs34285885; rs12035959; rs28758219; rs11464953; rs7543168; rs34470277; rs12034419; rs34385095; rs7520664; rs1635572; rs6673284; rs3795215; rs41266005; rs35236764; rs12405468; rs1635568; rs11203372; rs9699928; rs34232443; rs12746706; rs34298414; rs12089685; rs1635582; rs1635562; rs35385422; rs12217055; rs41266003; rs12743026; rs34576251; rs6664430; rs2477150; rs12036010; rs1635575; rs1748037; rs11344957; rs35095098; rs4920599; rs34199675; rs35943476; rs11802787; rs34213328; rs35076930; rs35658272; rs12042078; rs34897407; rs35025070; rs12737739; rs12039455; rs35326089; rs35023063; rs2477132; rs1635573; rs12568975; rs12567171; rs34686723; rs11403728; rs35210719; rs7520570; rs12082953; rs4506506; rs1748016; rs12569317; rs11578712; rs6698443; rs12754248; rs34742148; rs35581887; rs12042081; rs10667653; rs36072593; rs34677561; rs35348318; rs28868072; rs36164094; rs35695252; rs35412937; rs12405467; rs34957305; rs10437048; rs2477151; rs34960180; rs10693700; rs34632931; rs11327771; rs34965359; rs35072789; rs11372157; rs34965564; rs36097026; rs13376691; rs11421885; rs35287029; rs12038068; rs12731347; rs28639685; rs34581837; rs2501805; rs7520668; rs36096227; rs12042956; rs11586295; rs1748024; rs1635563; rs34852999; rs7545194; rs11364408; rs35809798; rs35644008; rs7525199; rs36026330; rs6665305; rs12084035; rs1748018; rs35442836; rs6695312; rs28814405; rs36142431; rs11587622; rs12085761; rs36070985; rs7530463; rs34871124; rs35111705; rs12733748; rs12752435; rs34364752; rs34212819; rs16825114; rs11203374; rs11203375; rs11800039; rs11800688; rs11801266; rs11801319; rs11809800; rs12044826; rs1204868; rs1204869; rs1204871; rs1204872; rs1204874; rs1204875; rs1204876; rs1204878; rs1204880; rs1204881; rs1204882; rs1204883; rs1204884; rs1204890; rs1204891; rs1204892; rs12048953; rs12059782; rs12096509; rs12098152; rs12732819; rs12753129; rs12760347; rs12760504; rs2477136; rs2477137; rs2477138; rs2477141; rs2477142; rs2501778; rs2501779; rs2501781; rs2501782; rs2501785; rs2501786; rs2501787; rs2501788; rs2501789; rs2501793; rs2501794; rs2985375; rs2985376; rs2985377; rs3003449; rs3094885; rs4625336; rs6586516; rs6656582; rs6657142; rs6688265; rs6690363; rs6702029; rs6702779; rs7411021; rs7534816; rs7538597; rs877551; rs877552; rs877553; rs942459

# Metabolic_Enzyme_16_General_References:
10488123

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5869

# Metabolic_Enzyme_17_Name:
AMP deaminase 3

# Metabolic_Enzyme_17_Synonyms:
AMP deaminase isoform E; Erythrocyte AMP deaminase

# Metabolic_Enzyme_17_Gene_Name:
AMPD3

# Metabolic_Enzyme_17_Protein_Sequence:
>AMP deaminase 3
MPRQFPKLNISEVDEQVRLLAEKVFAKVLREEDSKDALSLFTVPEDCPIGQKEAKERELQ
KELAEQKSVETAKRKKSFKMIRSQSLSLQMPPQQDWKGPPAASPAMSPTTPVVTGATSLP
TPAPYAMPEFQRVTISGDYCAGITLEDYEQAAKSLAKALMIREKYARLAYHRFPRITSQY
LGHPRADTAPPEEGLPDFHPPPLPQEDPYCLDDAPPNLDYLVHMQGGILFVYDNKKMLEH
QEPHSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKEL
KSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFD
GLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARM
VKEVARELEESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKVYSPNMRWIIQVPRIYDIF
RSKKLLPNFGKMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDK
SPNPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAF
LTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSL
STDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYY
KEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITALTN

# Metabolic_Enzyme_17_Number_of_Residues:
767

# Metabolic_Enzyme_17_Molecular_Weight:
88813

# Metabolic_Enzyme_17_Theoretical_pI:
6.98

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  AMP deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Not Available

# Metabolic_Enzyme_17_Specific_Function:
AMP deaminase plays a critical role in energy metabolism

# Metabolic_Enzyme_17_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_17_Reaction:
AMP + H2O = IMP + ammonia

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_17_Signals:
None

# Metabolic_Enzyme_17_Transmembrane_Regions:
None

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 3.5.4.6

# Metabolic_Enzyme_17_GenBank_ID_Protein:
219457

# Metabolic_Enzyme_17_SwissProt_ID:
AMPD3_HUMAN (Q01432)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
AMPD3

# Metabolic_Enzyme_17_Geneatlas_id:
AMPD3

# Metabolic_Enzyme_17_hgnc_id:
HGNC:470

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_17_Gene_Sequence:
>2304 bp
ATGCCGCGGCAGTTTCCCAAGCTGAACATCTCTGAAGTGGATGAGCAAGTCCGGCTCCTG
GCGGAGAAGGTGTTTGCTAAAGTGCTCCGAGAAGAGGACAGCAAAGATGCCCTGTCCCTG
TTCACTGTCCCAGAGGACTGCCCCATCGGGCAAAAGGAAGCCAAGGAGAGGGAGCTGCAG
AAGGAGCTGGCAGAGCAGAAGTCTGTGGAGACCGCAAAAAGAAAGAAAAGTTTCAAGATG
ATTCGGTCCCAGTCCCTGTCTCTGCAAATGCCGCCACAGCAAGATTGGAAGGGCCCCCCG
GCAGCCAGTCCGGCCATGTCTCCCACAACCCCTGTGGTCACTGGAGCCACTTCCCTGCCC
ACGCCAGCACCCTATGCCATGCCTGAGTTCCAGCGGGTCACCATCAGCGGAGATTACTGT
GCCGGGATCACTTTGGAGGACTATGAGCAGGCAGCCAAGAGTCTGGCCAAGGCCCTAATG
ATCCGGGAGAAGTATGCGCGGCTCGCCTACCACCGCTTCCCGCGGATCACATCCCAGTAC
CTGGGTCATCCGCGGGCGGATACTGCACCTCCGGAAGAGGGCCTTCCAGACTTCCACCCT
CCTCCACTGCCCCAGGAAGACCCCTACTGCCTGGATGATGCACCCCCCAACCTGGATTAC
TTGGTCCACATGCAGGGGGGCATCCTCTTTGTGTATGATAACAAGAAGATGCTGGAGCAC
CAGGAGCCGCACAGCCTACCCTACCCCGACCTGGAGACCTACACGGTGGACATGAGCCAC
ATCCTGGCTCTCATCACCGATGGCCCCACGAAAACCTATTGTCACCGGCGACTGAACTTT
CTGGAATCCAAGTTCAGCCTTCATGAGATGTTAAACGAAATGTCCGAGTTCAAAGAGTTG
AAGAGTAACCCCCACCGGGACTTCTATAACGTGAGAAAGGTGGACACACACATCCATGCG
GCCGCCTGCATGAACCAAAAGCATCTGCTGCGCTTCATCAAGCACACATACCAGACGGAG
CCTGACAGGACTGTGGCAGAGAAGCGGGGCCGGAAGATCACCCTGCGGCAGGTGTTTGAC
GGCCTGCACATGGACCCCTACGACCTCACTGTGGACTCACTGGATGTCCACGCGGGCCGG
CAGACATTCCACCGCTTTGACAAGTTCAACTCCAAATACAACCCTGTGGGGGCCAGTGAG
CTGCGTGACCTGTATTTGAAAACTGAAAACTATCTGGGAGGAGAGTACTTTGCTCGGATG
GTCAAGGAGGTTGCCCGGGAGCTGGAGGAGAGCAAGTACCAGTACTCAGAGCCACGGCTC
TCCATCTACGGCCGCAGTCCTGAGGAGTGGCCCAACCTGGCCTACTGGTTCATCCAGCAC
AAGGTCTACTCTCCCAACATGCGCTGGATCATCCAGGTGCCCCGGATTTATGACATATTT
AGGTCAAAGAAGCTGCTGCCAAACTTTGGGAAGATGCTGGAGAACATCTTCCTGCCCCTT
TTCAAGGCCACTATCAACCCCCAAGATCATCGAGAGCTTCACCTCTTCCTTAAATATGTG
ACGGGGTTTGACAGCGTGGATGATGAGTCCAAGCACAGCGACCACATGTTTTCCGACAAG
AGCCCAAACCCGGACGTCTGGACCAGTGAGCAGAACCCACCCTACAGCTACTACCTGTAC
TACATGTATGCCAACATCATGGTGCTCAACAACCTCCGCAGGGAGCGCGGCCTGAGCACG
TTCCTGTTCCGGCCGCACTGTGGGGAAGCCGGCTCCATCACCCACCTGGTGTCTGCCTTC
CTCACTGCTGACAACATTTCCCACGGGCTGCTCCTCAAGAAGAGTCCGGTATTGCAGTAT
CTCTACTACCTTGCTCAGATCCCCATTGCCATGTCTCCTCTTAGCAACAACAGTTTGTTC
CTCGAATATTCCAAGAACCCTCTGAGGGAATTCCTACACAAGGGACTGCATGTTTCTCTT
TCCACCGATGACCCCATGCAGTTCCACTACACGAAGGAAGCACTTATGGAAGAATATGCC
ATTGCAGCTCAAGTGTGGAAGCTGAGCACCTGCGACCTGTGTGAGATCGCCAGGAACAGC
GTGCTGCAGAGCGGCCTCTCGCATCAGGAAAAGCAAAAGTTTCTGGGACAAAATTATTAT
AAAGAAGGACCTGAAGGAAATGATATTCGAAAGACAAATGTGGCTCAGATCCGGATGGCA
TTCCGATATGAGACCTTATGCAATGAGCTCAGCTTCCTGTCTGATGCTATGAAATCAGAA
GAGATCACCGCCTTGACCAACTAG

# Metabolic_Enzyme_17_GenBank_ID_Gene:
D12775

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_17_Locus:
11p15

# Metabolic_Enzyme_17_SNPs:
rs11042836; rs36003153; rs3741041; rs16907852; rs34319136; rs11820856; rs899013; rs899011; rs899010; rs1037998; rs936513; rs936514; rs9292; rs1545743; rs7109334; rs11822997; rs930672; rs7416; rs2071020; rs7123980; rs7124144; rs2071019; rs1466426; rs2071018; rs7113101; rs1001118; rs7122280; rs11042840; rs10840419; rs3741037; rs10437597; rs10840427; rs3891547; rs2071017; rs11826750; rs10840429; rs11042854; rs12419888; rs12795565; rs11042830; rs10770120; rs11042841; rs3802917; rs11042846; rs3741038; rs11602933; rs11042853; rs7943804; rs11042849; rs17401498; rs7105307; rs11601268; rs7128132; rs12271597; rs11042855; rs11042833; rs4910146; rs7107588; rs7125606; rs12416948; rs6484336; rs4910140; rs10840424; rs11042850; rs16907878; rs11042842; rs10840425; rs11042834; rs16907858; rs11042828; rs11042848; rs899014; rs11042856; rs7127884; rs1466427; rs7124537; rs10770122; rs7934278; rs2071016; rs7125888; rs10840431; rs4910143; rs11042832; rs11042851; rs12800954; rs12284970; rs4910141; rs11042864; rs6484302; rs7934815; rs11042839; rs16907891; rs12421214; rs16907836; rs16907914; rs16907919; rs10840428; rs3741043; rs7110563; rs3741039; rs11042831; rs4910144; rs4909930; rs10770119; rs7114333; rs17310342; rs11042852; rs12290824; rs7949917; rs10840420; rs11042859; rs11042843; rs7944154; rs4909932; rs10840430; rs11042847; rs16907868; rs7101748; rs10840422; rs922360; rs10770118; rs10840421; rs16907909; rs16907896; rs7130140; rs16907917; rs7101934; rs11042835; rs12418145; rs11042844; rs11042863; rs10840423; rs7932321; rs4909931; rs7950039; rs4909928; rs7929999; rs4909929; rs7111970; rs12161765; rs6484290; rs7112321; rs6484291; rs4910139; rs3741040; rs12418097; rs1803101; rs416372; rs11278140; rs10592594; rs34205084; rs10666578; rs376859; rs35285382; rs35234722; rs34276239; rs2403330; rs433847; rs35548473; rs922359; rs35027484; rs5029459; rs34686247; rs11042817; rs2169594; rs36117985; rs28403593; rs12360830; rs35815414; rs28403594; rs35417007; rs34947038; rs11042816; rs34448488; rs34793322; rs11455471; rs7120456; rs12804742; rs35753139; rs12789944; rs12295824; rs35307925; rs35469290; rs11042827; rs11042815; rs12285554; rs10770121; rs11042837; rs10437667; rs389793; rs4909933; rs12291731; rs411593; rs12291443; rs7937616; rs11042857; rs12295125; rs5789638; rs11042813; rs34796012; rs34400211; rs10466517; rs11327316; rs35172583; rs12284303; rs10466406; rs12287821; rs36106536; rs7107965; rs11042812; rs35535464; rs36075284; rs12271609; rs446512; rs11042826; rs10466515; rs12221503; rs12293113; rs10840426; rs11042845; rs10743142; rs11042862; rs403952; rs34388590; rs34972496; rs34843534; rs12790244; rs7119606; rs11522665; rs10466514; rs12292471; rs35410520; rs12575256; rs12786914; rs12224969; rs12287504; rs35022461; rs35501680; rs34957142; rs4910142; rs12184411; rs11042860; rs16907904; rs35803105; rs34769794; rs34045306; rs35148074; rs11346179; rs11042838; rs34159907; rs4910147; rs11279688; rs34735568; rs35724616; rs10466404; rs35916834; rs7937988; rs35909829; rs12803441; rs4909934; rs4369398; rs7951269; rs11042861; rs34779745; rs34942282; rs11530493; rs11820349; rs9736934; rs11042829; rs35114038; rs10466516; rs12802491; rs12284175; rs10709823; rs11042818; rs36119682; rs35629432; rs11042858; rs12291294; rs34456454; rs36120251; rs11042814; rs11042811; rs11042825; rs36032769; rs7107565; rs7937289; rs7107698; rs7124271; rs10643285; rs36206458; rs8181594; rs7938316; rs11042810; rs10590775; rs1043778; rs10500725; rs1074375; rs10770123; rs10840415; rs10840416; rs10840417; rs10840418; rs11042805; rs11042806; rs11042865; rs11042866; rs11042867; rs11042868; rs11602469; rs11607008; rs12164827; rs12225339; rs12280618; rs12290357; rs12363993; rs12448; rs12789639; rs16907826; rs1870951; rs3177103; rs3741036; rs374925; rs382044; rs383090; rs394242; rs411783; rs4146830; rs428325; rs446762; rs4910149; rs4910150; rs570362; rs6484281; rs677322; rs7119498; rs7939845; rs7948437; rs899012; rs9971562

# Metabolic_Enzyme_17_General_References:
1420359; 1400401; 8611627; 8004104

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5947

# Metabolic_Enzyme_18_Name:
Pyridoxine-5'-phosphate oxidase

# Metabolic_Enzyme_18_Synonyms:
Pyridoxamine-phosphate oxidase

# Metabolic_Enzyme_18_Gene_Name:
PNPO

# Metabolic_Enzyme_18_Protein_Sequence:
>Pyridoxine5'phosphate oxidase
MTCWLRGVTATFGRPAEWPGYLSHLCGRSAAMDLGPMRKSYRGDREAFEETHLTSLDPVK
QFAAWFEEAVQCPDIGEANAMCLATCTRDGKPSARMLLLKGFGKDGFRFFTNFESRKGKE
LDSNPFASLVFYWEPLNRQVRVEGPVKKLPEEEAECYFHSRPKSSQIGAVVSHQSSVIPD
REYLRKKNEELEQLYQDQEVPKPKSWGGYVLYPQVMEFWQGQTNRLHDRIVFRRGLPTGD
SPLGPMTHRGEEDWLYERLAP

# Metabolic_Enzyme_18_Number_of_Residues:
261

# Metabolic_Enzyme_18_Molecular_Weight:
29988

# Metabolic_Enzyme_18_Theoretical_pI:
7.09

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
Function:  pyridoxamine-phosphate oxidase activity
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  vitamin metabolism
Process:  water-soluble vitamin metabolism
Process:  vitamin B6 metabolism
Process:  pyridoxine metabolism
Process:  pyridoxine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_18_Specific_Function:
Oxidizes PNP and PMP into pyridoxal 5'-phosphate (PLP)

# Metabolic_Enzyme_18_Pathway:
map00750  Vitamin B6 metabolism

# Metabolic_Enzyme_18_Reaction:
pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + ammonia + H2O2

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF01243:Pyridox_oxidase

# Metabolic_Enzyme_18_Signals:
None

# Metabolic_Enzyme_18_Transmembrane_Regions:
None

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 1.4.3.5

# Metabolic_Enzyme_18_GenBank_ID_Protein:
21728336

# Metabolic_Enzyme_18_SwissProt_ID:
PNPO_HUMAN (Q9NVS9)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
PNPO

# Metabolic_Enzyme_18_Geneatlas_id:
PNPO

# Metabolic_Enzyme_18_hgnc_id:
HGNC:30260

# Metabolic_Enzyme_18_PDB_ID:
1NRG

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Not Available

# Metabolic_Enzyme_18_Gene_Sequence:
>786 bp
ATGACGTGCTGGCTGCGGGGCGTCACGGCGACGTTCGGGCGACCTGCCGAGTGGCCAGGC
TACCTCAGTCACCTGTGTGGTCGCAGTGCTGCCATGGACCTGGGACCCATGCGCAAGAGT
TACCGCGGGGACCGAGAGGCATTTGAGGAGACTCATCTGACCTCCCTTGACCCAGTGAAA
CAGTTTGCTGCCTGGTTTGAGGAGGCTGTTCAGTGTCCTGACATAGGGGAAGCCAATGCC
ATGTGTCTGGCTACCTGCACCAGAGATGGAAAACCCTCTGCTCGCATGTTGCTGCTGAAG
GGCTTCGGGAAAGATGGCTTCCGCTTCTTCACTAACTTCGAGAGTCGAAAAGGAAAAGAG
CTGGACTCTAATCCCTTTGCTTCCCTTGTCTTCTACTGGGAGCCACTTAACCGTCAGGTG
CGTGTGGAAGGCCCTGTGAAGAAACTGCCTGAGGAGGAGGCTGAGTGCTACTTCCACTCC
CGCCCCAAGAGCAGCCAGATTGGGGCTGTGGTCAGCCACCAGAGTTCTGTGATCCCTGAT
CGGGAGTATCTGAGAAAGAAAAATGAGGAACTGGAACAGCTCTACCAGGATCAAGAGGTG
CCCAAGCCAAAATCCTGGGGTGGCTATGTCCTGTACCCTCAGGTGATGGAGTTCTGGCAA
GGTCAAACCAACCGCCTGCATGACCGGATAGTCTTTCGGCGGGGCCTACCCACAGGAGAT
TCCCCTTTGGGGCCCATGACCCACCGCGGGGAGGAAGACTGGCTCTATGAGAGACTTGCA
CCTTAA

# Metabolic_Enzyme_18_GenBank_ID_Gene:
AF468030

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_18_Locus:
17q21.32

# Metabolic_Enzyme_18_SNPs:
rs17679445; rs11079804; rs4378657; rs7220104; rs7219707; rs2325749; rs16949676; rs2002136; rs16949651; rs11079803; rs2325750; rs9894340; rs2325751; rs1986694; rs7208554; rs3764398; rs35974730; rs1962201; rs35312568; rs34482109; rs34388466; rs10665680; rs35685159; rs7214659; rs35742801; rs3047638; rs11657774; rs28547560; rs4539646; rs7210233; rs11079802; rs11545723; rs11650043; rs11651753; rs11652185; rs11652827; rs12449469; rs12453525; rs12939788; rs12941340; rs12951323; rs16949720; rs16949737; rs16949761; rs17617250; rs1986693; rs2597169; rs2597170; rs2875735; rs3096; rs34428844; rs3764396; rs3764399; rs3826396; rs4538050; rs4793729; rs4793733; rs4793734; rs4794318; rs6503934; rs8065349; rs9896981; rs9908317; rs9909897

# Metabolic_Enzyme_18_General_References:
12824491

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5948

# Metabolic_Enzyme_19_Name:
Glutaminase liver isoform, mitochondrial precursor

# Metabolic_Enzyme_19_Synonyms:
GLS; L-glutamine amidohydrolase; L-glutaminase

# Metabolic_Enzyme_19_Gene_Name:
GLS2

# Metabolic_Enzyme_19_Protein_Sequence:
>Glutaminase liver isoform, mitochondrial precursor
MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQD
HDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQ
ESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVA
AYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHK
FVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAG
NEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESG
SVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGA
ILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGA
EIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIE
ACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLES
MV

# Metabolic_Enzyme_19_Number_of_Residues:
602

# Metabolic_Enzyme_19_Molecular_Weight:
66324

# Metabolic_Enzyme_19_Theoretical_pI:
7.32

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Function:  glutaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_19_Specific_Function:
Plays an important role in the regulation of glutamine catabolism

# Metabolic_Enzyme_19_Pathway:
map00251  Glutamate metabolism;
 map00471  D-Glutamine and D-glutamate metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_19_Reaction:
L-glutamine + H2O = L-glutamate + NH3

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF00023:Ank;
PF04960:Glutaminase

# Metabolic_Enzyme_19_Signals:
None

# Metabolic_Enzyme_19_Transmembrane_Regions:
None

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 3.5.1.2

# Metabolic_Enzyme_19_GenBank_ID_Protein:
6650606

# Metabolic_Enzyme_19_SwissProt_ID:
GLSL_HUMAN (Q9UI32)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
GLS2

# Metabolic_Enzyme_19_Geneatlas_id:
GLS2

# Metabolic_Enzyme_19_hgnc_id:
HGNC:29570

# Metabolic_Enzyme_19_PDB_ID:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_19_Gene_Sequence:
>1809 bp
ATGCGCTCCATGAAGGCTCTGCAGAAGGCCCTGAGCCGGGCTGGCAGTCACTGCGGGCGA
GGAGGCTGGGGTCACCCGAGCCGGAGCCCCCTCCTTGGCGGGGGCGTCCGGCACCACCTC
AGTGAGGCCGCGGCGCAGGGCAGAGAGACGCCACACAGCCACCAGCCGCAGCACCAGGAT
CATGATTCATCAGAAAGTGGCATGCTGTCCCGCCTGGGTGATTTGCTCTTTTACACTATT
GCTGAAGGACAGGAACGAACCCCTATCCACAAGTTCACCACTGCACTAAAGGCCACTGGA
CTGCAGACATCAGATCCTCGGCTCCGAGACTGCATGAGCGAGATGCACCGCGTGGTCCAA
GAGTCCAGTAGTGGTGGCCTCTTGGACCGAGATCTCTTCCGAAAGTGTGTGAGCAGCAGC
ATTGTGCTCCTGACCCAGGCATTCCGAAAGAAGTTTGTCATTCCTGATTTTGAGGAGTTC
ACGGGCCATGTGGATCGCATCTTTGAGGATGTCAAAGAGCTCACTGGAGGCAAAGTGGCA
GCCTACATCCCTCAGCTGGCCAAGTCAAACCCAGACCTGTGGGGTGTCTCCCTGTGCACT
GTGGATGGTCAACGGCACTCTGTGGGCCACACAAAGATCCCCTTCTGCCTGCAGTCCTGT
GTGAAGCCCCTCACCTATGCCATCTCCATAAGCACCCTAGGCACTGACTACGTGCACAAG
TTTGTGGGCAAAGAGCCAAGTGGCCTGCGCTACAACAAGCTCTCCCTCGATGAGGAAGGA
ATCCCCCATAACCCCATGGTCAATGCTGGTGCCATTGTTGTCAGCTCCCTGATCAAGATG
GACTGTAACAAAGCAGAGAAGTTTGATTTTGTGTTGCAGTATCTCAACAAAATGGCTGGG
AATGAATACATGGGTTTCAGCAATGCCACATTCCAGTCAGAGAAGGAAACAGGGGATCGG
AATTATGCCATCGGCTATTATCACGAGGAAAAGAAGTGCTTTCCTAAGGGGGTGGACATG
ATGGCTGCCCTTGATCTCTACTTCCAGCTGTGTTCTGTGGAGGTCACTTGTGAATCAGGC
AGTGTCATGGCAGCCACCCTCGCCAACGGTGGGATTTGCCCCATCACAGGCGAGAGTGTG
CTGAGTGCTGAAGCAGTGCGCAACACCCTCAGCCTCATGCATTCCTGCGGCATGTATGAC
TTCTCTGGCCAGTTTGCCTTCCACGTGGGCCTGCCAGCCAAGTCAGCTGTATCAGGAGCC
ATCCTCCTGGTGGTACCCAATGTCATGGGAATGATGTGCCTGTCACCCCCATTGGACAAG
CTGGGGAACAGCCATAGGGGGACCAGCTTCTGCCAGAAGTTGGTGTCTCTCTTCAATTTC
CACAACTATGACAACCTGAGGCACTGTGCTCGGAAGTTAGACCCACGGCGTGAAGGGGCA
GAAATTCGGAACAAGACTGTGGTCAACCTGTTATTTGCTGCCTATAGTGGCGATGTCTCA
GCTCTTCGAAGGTTTGCCTTGTCAGCCATGGATATGGAACAGAAAGACTATGACTCGCGC
ACAGCTCTGCATGTTGCTGCAGCTGAAGGACACATCGAAGTTGTTAAATTCCTGATCGAG
GCTTGCAAAGTGAATCCTTTTGCCAAGGACAGGTGGGGCAACATTCCCCTGGATGATGCT
GTGCAGTTCAACCATCTGGAGGTGGTCAAACTGCTTCAAGATTACCAGGACTCCTACACA
CTCTCTGAAACTCAGGCTGAGGCAGCAGCTGAGGCCCTGTCCAAAGAGAACTTAGAAAGC
ATGGTATGA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
AF110330

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_19_Locus:
12q13

# Metabolic_Enzyme_19_SNPs:
rs2657879; rs1043011; rs2638315; rs937115; rs7314242; rs937114; rs6581096; rs2638314; rs11171863; rs12299914; rs2638335; rs4759244; rs7137402; rs12304519; rs7306152; rs2638336; rs7312783; rs2657878; rs11171862; rs3809122; rs2638334; rs11834429; rs3211277; rs34265700; rs2279536; rs12229485; rs5798384; rs11439704; rs35400268; rs10876892; rs35894333; rs11171861; rs11441969; rs7314504; rs35171220; rs34950500; rs12819483; rs35762642; rs2657877; rs34325581; rs11414489; rs35090234; rs34646954; rs12811540; rs11171864; rs34647708; rs12811321; rs12809968; rs35530001; rs10124; rs10876891; rs12313841; rs2638285; rs2638317; rs2638318; rs2638319; rs2657880; rs2657881; rs2657914; rs7298079; rs7302925; rs765817

# Metabolic_Enzyme_19_General_References:
10620514; 11163757

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
5817

# Metabolic_Enzyme_20_Name:
Biotinidase precursor

# Metabolic_Enzyme_20_Synonyms:
Not Available

# Metabolic_Enzyme_20_Gene_Name:
BTD

# Metabolic_Enzyme_20_Protein_Sequence:
>Biotinidase precursor
MSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVAAVYEHPSILSLNPLALISRQ
EALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPQVVRW
NPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCHSSDPRCPKDGRYQFNTNVVF
SNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRFGIFTCFDILFFDPAIRVLRD
YKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAANVHHPVLGMTGSGIHTPLESF
WYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSKFLKILSGDPYCEKDAQEVHC
DEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSNGLCCYLLYERPTLSKELYAL
GVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATGIFEFHLWGNFSTSYIFPLFL
TSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLYERD

# Metabolic_Enzyme_20_Number_of_Residues:
523

# Metabolic_Enzyme_20_Molecular_Weight:
58914

# Metabolic_Enzyme_20_Theoretical_pI:
5.72

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  nitrogen compound metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_20_General_Function:
Not Available

# Metabolic_Enzyme_20_Specific_Function:
Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation

# Metabolic_Enzyme_20_Pathway:
map00780  Biotin metabolism

# Metabolic_Enzyme_20_Reaction:
biotin amide + H2O = biotin + NH3

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00795:CN_hydrolase

# Metabolic_Enzyme_20_Signals:
1-21

# Metabolic_Enzyme_20_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 3.5.1.12

# Metabolic_Enzyme_20_GenBank_ID_Protein:
468824

# Metabolic_Enzyme_20_SwissProt_ID:
BTD_HUMAN (P43251)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
BTD

# Metabolic_Enzyme_20_Geneatlas_id:
BTD

# Metabolic_Enzyme_20_hgnc_id:
HGNC:1122

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_20_Gene_Sequence:
>1632 bp
ATGGCGCATGCGCATATTCAGGGCGGAAGGCGCGCTAAGAGCAGATTTGTGGTCTGCATT
ATGTCTGGAGCCAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTG
GGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGAGGCTGAATATTATGTGGCT
GCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAA
GAGGCCTTGGAGCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCA
GCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGGCATTCATGGATTCAACTTT
ACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGG
AACCCATGCCTGGAGCCTCACCGCTTCAATGACACAGAGGTGCTCCAGCGCCTGAGTTGT
ATGGCCATCAGGGGAGATATGTTCTTGGTGGCCAATCTTGGGACAAAGGAGCCTTGTCAT
AGCAGTGACCCAAGGTGCCCAAAAGATGGGAGATACCAGTTCAACACAAATGTCGTGTTC
AGCAATAATGGAACCCTTGTTGACCGCTACCGTAAACACAACCTCTACTTTGAGGCAGCA
TTCGATGTTCCTCTTAAAGTGGATCTCATCACCTTTGATACCCCCTTTGCTGGCAGGTTT
GGCATCTTCACATGCTTTGATATATTGTTCTTTGACCCTGCCATCAGAGTCCTCAGAGAC
TACAAGGTGAAGCATGTTGTGTACCCAACTGCCTGGATGAACCAGCTCCCACTCTTGGCA
GCAATTGAGATTCAGAAAGCTTTTGCTGTTGCCTTTGGCATCAACGTTCTGGCAGCTAAT
GTCCACCACCCAGTTCTGGGGATGACAGGAAGTGGCATACACACCCCTCTGGAGTCCTTT
TGGTACCATGACATGGAAAATCCCAAAAGTCACCTTATAATTGCCCAGGTGGCCAAAAAT
CCAGTGGGTCTCATTGGTGCAGAGAATGCAACAGGTGAAACGGACCCATCCCATAGTAAG
TTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCACTGT
GATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTAT
GACAATTTCACCCTGGTCCCTGTCTGGGGAAAGGAAGGCTATCTCCACGTCTGTTCCAAT
GGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCCCTG
GGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTG
GTCAGGTGTGGGGGTCTTGGCTTCGACACCTGCGGACAGGAAATCACAGAGGCCACGGGG
ATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTTCTG
ACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTC
CTGAGGAAAAGTAGGCTGTCCTCTGGGCTGGTGACGGCGGCTCTCTATGGGCGCTTGTAT
GAGAGGGACTAG

# Metabolic_Enzyme_20_GenBank_ID_Gene:
U03274

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_20_Locus:
3p25

# Metabolic_Enzyme_20_SNPs:
rs35034250; rs13078881; rs3817641; rs924814; rs2471809; rs2455826; rs4094397; rs2455820; rs9853116; rs2455810; rs1021849; rs2455916; rs9880034; rs4478067; rs2280770; rs13320591; rs760066; rs2471807; rs11128749; rs7651039; rs6773682; rs2455827; rs2470526; rs12489825; rs2455823; rs2470529; rs2455915; rs10510441; rs13319547; rs741747; rs741748; rs9858977; rs9310480; rs9866477; rs1296433; rs2734308; rs9858784; rs7640807; rs34356435; rs9310481; rs9849809; rs10212184; rs12330387; rs7621332; rs4626087; rs9827673; rs4309707; rs9825546; rs2455828; rs9310479; rs9830528; rs17041367; rs2470551; rs12639040; rs6807875; rs9836533; rs2174267; rs28934601; rs35976361; rs13073139; rs34885143; rs35145938; rs28475858; rs28612795; rs2055564; rs9838247; rs13066152; rs12494340; rs11714810; rs34101231; rs34976221; rs11916854; rs2471806; rs4298027; rs2470528; rs2455918; rs6803821; rs12493340; rs35141065; rs35452512; rs2470541; rs2654647; rs12631444; rs2455825; rs13068169; rs9873582; rs13075998; rs35719864; rs4685254; rs2734309; rs35863533; rs35004427; rs10621505; rs28576968; rs36065590; rs11915606; rs12330789; rs4407396; rs11717801; rs13088542; rs9755; rs35369543; rs7620644; rs9825684; rs4582034; rs35742912; rs28450862; rs28758269; rs34826323; rs7429324; rs2470527; rs13099874; rs35741795; rs34655059; rs9867921; rs36018115; rs2455822; rs2455824; rs28374257; rs6800368; rs1504098; rs1875798; rs2455917; rs9882597; rs11369757; rs11405819; rs6773959; rs35402548; rs9838246; rs34597886; rs36078683; rs35244780; rs2455821; rs35735277; rs9847991; rs9840496; rs34143777; rs34795748; rs2280771; rs12488812; rs34408221; rs28553993; rs9868928; rs9870498; rs35638740; rs13061544; rs34718841; rs35175965; rs2470525; rs4684257; rs36053401; rs11918810; rs12490588; rs13076664; rs13076834; rs13076843; rs13099347; rs1504099; rs2004783; rs2014933; rs2019160; rs2089054; rs2134784; rs2279841; rs2455852; rs2455853; rs2455854; rs2470530; rs2470531; rs2470532; rs2734307; rs3732720; rs3796302; rs3796305; rs6773994; rs6784844; rs6804782; rs7626148; rs869569; rs905555; rs9647358; rs9830541; rs9834785; rs9879788

# Metabolic_Enzyme_20_General_References:
7509806; 9530634; 9099842; 9654207

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
5627

# Metabolic_Enzyme_21_Name:
Amiloride-sensitive amine oxidase [copper-containing] precursor

# Metabolic_Enzyme_21_Synonyms:
Diamine oxidase; DAO; Amiloride-binding protein; ABP; Histaminase; Kidney amine oxidase; KAO

# Metabolic_Enzyme_21_Gene_Name:
ABP1

# Metabolic_Enzyme_21_Protein_Sequence:
>Amiloridesensitive amine oxidase coppercontaining precursor
MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS
TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP
GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR
CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG
KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP
RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG
GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE
MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH
ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT
NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSM
ADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWDPPVVFEQFLHNNENI
ENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRD
NGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV

# Metabolic_Enzyme_21_Number_of_Residues:
751

# Metabolic_Enzyme_21_Molecular_Weight:
85342

# Metabolic_Enzyme_21_Theoretical_pI:
7.01

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_21_Specific_Function:
Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function

# Metabolic_Enzyme_21_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_21_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_21_Signals:
1-19

# Metabolic_Enzyme_21_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_21_GenBank_ID_Protein:
177960

# Metabolic_Enzyme_21_SwissProt_ID:
ABP1_HUMAN (P19801)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
ABP1

# Metabolic_Enzyme_21_Geneatlas_id:
ABP1

# Metabolic_Enzyme_21_hgnc_id:
HGNC:80

# Metabolic_Enzyme_21_PDB_ID:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_21_Gene_Sequence:
>2142 bp
ATGCCGGCCCTGGGCTGGGCCGTGGCTGCCATCCTGATGCTGCAGACGGCCATGGCGGAG
CCCTCCCCGGGGACTCTGCCCAGGAAGGCAGGGGTGTTTTCAGACCTAAGCAACCAAGAG
CTGAAGGCAGTGCACAGCTTCCTCTGGTCCAAGAAGGAGCTGAGGCTGCAGCCCTCCAGT
ACCACCACCATGGCCAAGAACACCGTGTTTCTCATCGAGATGCTGCTGCCCAAGAAGTAC
CATGTGCTGAGGTTTCTGGATAAAGGTGAAAGGCATCCTGTGCGGGAAGCCCGTGCCGTC
ATCTTCTTTGGTGACCAGGAGCATCCCAATGTCACCGAGTTTGCTGTGGGGCCCCTGCCA
GGGCCCTGCTACATGCGAGCACTGTCCCCCAGGCCTGGGTACCAGTCCTCCTGGGCATCG
AGGCCCATCTCCACAGCAGAGTATGCCCTCCTCTACCACACCCTGCAGGAAGCCACCAAG
CCCCTGCATCAGTTCTTCCTCAATACCACAGGCTTCTCATTCCAAGACTGCCATGACAGA
TGCCTGGCCTTCACCGATGTGGCCCCCCGGGGTGTGGCTTCTGGCCAGCGCCGCAGTTGG
CTTATCATACAGCGCTATGTAGAAGGCTACTTTCTGCACCCCACTGGGCTGGAGCTCCTC
GTGGATCATGGGAGCACAGATGCTGGGCACTGGGCCGTGGAGCAGGTGTGGTACAACGGG
AAGTTCTATGGGAGCCCAGAGGAACTGGCACGGAAGTATGCAGATGGAGAGGTGGACGTG
GTGGTCCTGGAGGACCGCTGCCTGGGGGCAAGGGGCATGACAGCACAGAGGAGCCGGCCC
TCTTCTCCTCCACAAGCCCCGCGGGACTTTCCCCAGCCCCATCCATGTGAGCGGCCCCCG
CTTGGTCCAGCCCCACGGCCCTCGCTTCAGGCTGGAGGGCAACGCTGTGCTCTACGGCGG
CTGGAGCTTTGCCTTCCGGTGCGCTCCTCCTCCGGGCTGCAGGTCCTGAACGTGCACTTC
GGCGGAGAGCGCATTGCCTATGAGGTCAGCGTGCAAGAGGCAGTGGCGCTGTATGGAGGA
CACACACCTGCAGGCATGCAGACCAAGTACCTCGATGTCGGCTGGGGCCTGGGCAGCGTC
ACTCATGAGTTAGCCCCCGGCATCGACTGCCCGGAGACCGCCACCTTCCTGGACACTTTC
CACTACTATGATGCCGATGACCCGGTCCATTATCCCCGAGCCCTCTGCCTCTTTGAAATG
CCCACAGGGGTGCCCCTTCGGCGGCACTTTAATTCCAACTTTAAAGGTGGCTTCAACTTC
TATGCAGGGCTGAAGGGCCAGGTGCTGGTGCTGCGGACAACTTCAACTGTCTACAATTAT
GATTACATTTGGGACTTTATCTTCTACCCCAACGGGGTGATGGAGGCCAAGATGCATGCC
ACTGGCTACGTCCACGCCACCTTCTACACCCCCGAGGGCTGCGCACGGCACTCGCCTGCA
CACCCACCTGATTGGCAACATACACACTCACTTGTGCACTACCGCGTAGACCTGGATGTG
GCAGGCACCAAGAACAGCTTCCAGACACTGCAGATGAAGCTAGAAAACATCACCAACCCC
TGGAGCCCGAGACACCGCGTGGTCCAGCCAACTCTGGAGCAGACGCAGTACTCCTGGGAG
CGCCAGGCGGCCTTCCGCTTCAAAAGGAGGCTGCCCAAGTACCTGCTCTTTACCAGCCCC
CAGGAGAACCCCTGGGGCCACAAGCGCAGCTACCGCCTGCAGATCCACTCCATGGCCGAC
CAGGTGCTGCCCCCAGGCTGGCAGGAGGAGCAGGCCATCACCTGGGCAAGGTACCCCCTG
GCAGTGACCAAGTACCGGGAGTCAGAGCTGTGCAGCAGCAGCATCTACCACCAGAACGAC
CCCTGGGACCCGCCCGTGGTCTTTGAGCAGTTTCTTCACAACAACGAGAACATTGAAAAT
GAGGACCTGGTGGCCTGGGTGACGGTGGGCTTCCTGCACATCCCCCACTCAGAGGACATT
CCCAACACAGCCACACCTGGGAACTCCGTGGGCTTCCTGCTCCGGCCATTCAACTTCTTC
CCAGAGGACCCCTCCCCTCCCTGGCATCCAGAGACACTGTGA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
M55602

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_21_Locus:
7q34-q36

# Metabolic_Enzyme_21_SNPs:
rs10156191; rs1049742; rs35070995; rs1049793; rs1049748; rs10893; rs2071514; rs4725373; rs10441169; rs2268998; rs2071513; rs10156189; rs2268999; rs7786439; rs12539; rs12540862; rs11771771; rs2071515; rs11981415; rs11981217; rs3735076; rs10952294; rs4725968; rs2301257; rs2373876; rs10273373; rs2052130; rs2052129; rs2071517; rs17173645; rs2301256; rs4725375; rs4725970; rs35929142; rs6943147; rs41465145; rs6943420; rs10441176; rs7787074; rs7786420; rs7786526; rs35730790; rs10281706; rs35773682; rs8180720; rs13235597; rs13235592; rs13235484; rs34532106; rs4725969; rs4725374; rs4431514; rs35724462; rs10273148; rs34459590; rs34090933; rs35411492; rs34502771; rs1005389; rs1005390; rs10230025; rs10236489; rs10240738; rs10249948; rs10250599; rs10250704; rs10254616; rs10254802; rs10268640; rs11760854; rs11771001; rs11971392; rs11976328; rs11978239; rs12374688; rs12374823; rs12375106; rs1476867; rs2215563; rs2215564; rs4725376; rs4725377; rs4725971; rs6977081; rs6977381; rs7793572; rs7798657; rs887587; rs887588

# Metabolic_Enzyme_21_General_References:
2217167; 8182053; 8595053; 8144586

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
5937

# Metabolic_Enzyme_22_Name:
Adenosine deaminase

# Metabolic_Enzyme_22_Synonyms:
Adenosine aminohydrolase

# Metabolic_Enzyme_22_Gene_Name:
ADA

# Metabolic_Enzyme_22_Protein_Sequence:
>Adenosine deaminase
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL

# Metabolic_Enzyme_22_Number_of_Residues:
363

# Metabolic_Enzyme_22_Molecular_Weight:
40765

# Metabolic_Enzyme_22_Theoretical_pI:
5.80

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  adenosine deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_22_Specific_Function:
Adenosine + H(2)O = inosine + NH(3)

# Metabolic_Enzyme_22_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_22_Reaction:
adenosine + H2O = inosine + ammonia

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_22_Signals:
None

# Metabolic_Enzyme_22_Transmembrane_Regions:
None

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 3.5.4.4

# Metabolic_Enzyme_22_GenBank_ID_Protein:
28380

# Metabolic_Enzyme_22_SwissProt_ID:
ADA_HUMAN (P00813)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
ADA

# Metabolic_Enzyme_22_Geneatlas_id:
ADA

# Metabolic_Enzyme_22_hgnc_id:
HGNC:186

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_22_Gene_Sequence:
>1092 bp
ATGGCCCAGACGCCCGCCTTCGACAAGCCCAAAGTAGAACTGCATGTCCACCTAGACGGA
TCCATCAAGCCTGAAACCATCTTATACTATGGCAGGAGGAGAGGGATCGCCCTCCCAGCT
AACACAGCAGAGGGGCTGCTGAACGTCATTGGCATGGACAAGCCGCTCACCCTTCCAGAC
TTCCTGGCCAAGTTTGACTACTACATGCCTGCTATCGCGGGCTGCCGGGAGGCTATCAAA
AGGATCGCCTATGAGTTTGTAGAGATGAAGGCCAAAGAGGGCGTGGTGTATGTGGAGGTG
CGGTACAGTCCGCACCTGCTGGCCAACTCCAAAGTGGAGCCAATCCCCTGGAACCAGGCT
GAAGGGGACCTCACCCCAGACGAGGTGGTGGCCCTAGTGGGCCAGGGCCTGCAGGAGGGG
GAGCGAGACTTCGGGGTCAAGGCCCGGTCCATCCTGTGCTGCATGCGCCACCAGCCCAAC
TGGTCCCCCAAGGTGGTGGAGCTGTGTAAGAAGTACCAGCAGCAGACCGTGGTGGCCATT
GACCTGGCTGGAGATGAGACCATCCCAGGAAGCAGCCTCTTGCCTGGACATGTCCAGGCC
TACCAGGAGGCTGTGAAGAGCGGCATTCACCGTACTGTCCACGCCGGGGAGGTGGGCTCG
GCCGAAGTAGTAAAAGAGGCTGTGGACATACTCAAGACAGAGCGGCTGGGACACGGCTAC
CACACCCTGGAAGACCAGGCCCTTTATAACAGGCTGCGGCAGGAAAACATGCACTTCGAG
ATCTGCCCCTGGTCCAGCTACCTCACTGGTGCCTGGAAGCCGGACACGGAGCATGCAGTC
ATTCGGCTCAAAAATGACCAGGCTAACTACTCGCTCAACACAGATGACCCGCTCATCTTC
AAGTCCACCCTGGACACTGATTACCAGATGACCAAACGGGACATGGGCTTTACTGAAGAG
GAGTTTAAAAGGCTGAACATCAATGCGGCCAAATCTAGTTTCCTCCCAGAAGATGAAAAG
AGGGAGCTTCTCGACCTGCTCTATAAAGCCTATGGGATGCCACCTTCAGCCTCTGCAGGG
CAGAACCTCTGA

# Metabolic_Enzyme_22_GenBank_ID_Gene:
X02994

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_22_Locus:
20q12-q13.11

# Metabolic_Enzyme_22_SNPs:
rs244076; rs11906526; rs427224; rs244078; rs2299686; rs2224999; rs379863; rs8119702; rs8119756; rs244075; rs2299691; rs2007515; rs2057637; rs762539; rs447833; rs2057638; rs6031682; rs6031690; rs6031686; rs2299688; rs6031689; rs371927; rs244079; rs2007720; rs1799880; rs2299692; rs395209; rs399159; rs2299690; rs11700291; rs929089; rs406383; rs2057639; rs967807; rs244073; rs2299694; rs452159; rs2157436; rs6031693; rs2299687; rs6017375; rs446125; rs2477898; rs6103795; rs6017378; rs445170; rs6031685; rs765215; rs6031695; rs1810751; rs2299697; rs433875; rs6031688; rs6094011; rs765216; rs244072; rs6031687; rs2299689; rs427483; rs427499; rs11907906; rs12480490; rs6103803; rs6031697; rs6017371; rs6031678; rs375379; rs384851; rs395896; rs450043; rs6094005; rs6031679; rs11698539; rs389308; rs11086932; rs6103804; rs6065738; rs1042360; rs11555566; rs7344760; rs6031698; rs394105; rs36216718; rs5841559; rs34853885; rs6017373; rs34665505; rs2765290; rs3831638; rs35553416; rs2515692; rs6031694; rs6103801; rs6103792; rs36222732; rs10561362; rs6103799; rs35009045; rs6094008; rs2007704; rs11474041; rs6103794; rs445725; rs11905649; rs6017376; rs457669; rs35383274; rs6103796; rs368253; rs6130653; rs6031691; rs11468750; rs8118045; rs6094004; rs455368; rs11484279; rs6031696; rs912912; rs6103800; rs6031684; rs445856; rs6094007; rs6017377; rs755144; rs6094009; rs11481765; rs382464; rs6103789; rs35712615; rs404898; rs6124654; rs929088; rs6031692; rs35863085; rs414146; rs6031681; rs413816; rs6103790; rs6031683; rs35436165; rs35935728; rs11698497; rs11373171; rs3091476; rs36013790; rs5841560; rs11907079; rs6103793; rs34344438; rs6017374; rs34081313; rs35535317; rs6130651; rs7353732; rs11484329; rs3041775; rs451499; rs3787359; rs11476459; rs7262528; rs6103797; rs34225524; rs11480982; rs34830340; rs6094010; rs6094006; rs3787360; rs6073497; rs11473840; rs13036408; rs34044957; rs244074; rs6103788; rs6017372; rs386512; rs35483396; rs11468701; rs2299695; rs244077; rs35505353; rs36102321; rs35545345; rs6103802; rs6103791; rs6103798; rs3831639; rs34833873; rs35784536; rs35587028; rs420183; rs6130652; rs10645831; rs36216716; rs435679; rs36216717; rs6031700; rs35153391; rs1061662; rs11699718; rs1886849; rs2071878; rs2148040; rs244081; rs244082; rs244086; rs244087; rs2664524; rs2664557; rs2664560; rs2664582; rs2664585; rs2868116; rs3180636; rs4810427; rs4810428; rs6017369; rs6031673; rs6031674; rs6031675; rs6031676; rs6031677; rs6031702; rs6031704; rs6065739; rs6094001; rs6094002; rs6094003; rs6094016; rs6094017; rs6103786; rs6103787; rs6103805; rs6103806; rs6130650; rs6130654; rs7266968; rs8118020; rs927784

# Metabolic_Enzyme_22_General_References:
6090454; 6546794; 3839456; 3028473; 11780052; 6688808; 8031011; 6208479; 3839802; 3182793; 2783588; 1284479; 8227344; 8299233; 8589684; 7599635; 9225964

# Metabolic_Enzyme_22_References:
Not Available

# Metabolic_Enzyme_23_ID:
5949

# Metabolic_Enzyme_23_Name:
CTP synthase 1

# Metabolic_Enzyme_23_Synonyms:
UTP--ammonia ligase 1; CTP synthetase 1

# Metabolic_Enzyme_23_Gene_Name:
CTPS

# Metabolic_Enzyme_23_Protein_Sequence:
>CTP synthase 1
MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFV
LDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDA
IQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHV
SLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQ
VICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCS
IALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSADLEPITSQEEPVRYHEAWQK
LCSAHGVLVPGGFGVRGTEGKIQAIAWARNQKKPFLGVCLGMQLAVVEFSRNVLGWQDAN
STEFDPTTSHPVVVDMPEHNPGQMGGTMRLGKRRTLFQTKNSVMRKLYGDADYLEERHRH
RFEVNPVWKKCLEEQGLKFVGQDVEGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPY
FGLLLASVGRLSHYLQKGCRLSPRDTYSDRSGSSSPDSEITELKFPSINHD

# Metabolic_Enzyme_23_Number_of_Residues:
591

# Metabolic_Enzyme_23_Molecular_Weight:
66691

# Metabolic_Enzyme_23_Theoretical_pI:
6.42

# Metabolic_Enzyme_23_GO_Classification:
>>>
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  CTP synthase activity
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  pyrimidine nucleotide metabolism
Process:  pyrimidine nucleotide biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_23_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_23_Specific_Function:
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

# Metabolic_Enzyme_23_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_23_Reaction:
ATP + UTP + NH3 = ADP + phosphate + CTP

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF06418:CTP_synth_N;
PF00117:GATase

# Metabolic_Enzyme_23_Signals:
None

# Metabolic_Enzyme_23_Transmembrane_Regions:
None

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 6.3.4.2

# Metabolic_Enzyme_23_GenBank_ID_Protein:
30293

# Metabolic_Enzyme_23_SwissProt_ID:
PYRG1_HUMAN (P17812)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
CTPS

# Metabolic_Enzyme_23_Geneatlas_id:
CTPS

# Metabolic_Enzyme_23_hgnc_id:
HGNC:2519

# Metabolic_Enzyme_23_PDB_ID:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Not Available

# Metabolic_Enzyme_23_Gene_Sequence:
>1776 bp
ATGAAGTACATTCTGGTTACTGGTGGTGTTATATCAGGAATTGGAAAAGGAATCATTGCC
AGCAGTGTGGGCACAATACTCAAGTCATGTGGTTTACATGTAACTTCAATCAAAATTGAC
CCCTACATTAACATTGATGCAGGAACATTCTCTCCTTATGAGCATGGTGAGGTTTTTGTG
CTGGATGATGGTGGGGAAGTAGACCTTGACCTGGGTAACTATGAGCGGTTCCTTGACATC
CGCCTCACCAAGGACAATAATCTGACCACTGGAAAGATATACCAGTATGTCATTAACAAG
GAACGGAAAGGAGATTACTTGGGGAAAACTGTCCAAGTTGTCCCTCATATCACAGATGCA
ATCCAGGAGTGGGTGATGAGACAGGCGTTAATACCTGTAGATGAAGATGGCCTGGAACCT
CAAGTGTGTGTTATTGAGCTTGGTGGAACCGTGGGGGACATAGAAAGCATGCCCTTTATT
GAGGCCTTCCGTCAGTTCCAATTCAAGGTCAAAAGAGAGAACTTTTGTAACATCCACGTC
AGTCTAGTTCCCCAGCCAAGTTCAACAGGGGAACAGAAGACTAAACCTACCCAGAATAGT
GTTCGGGAACTTAGAGGACTTGGGCTTTCCCCAGATCTGGTTGTATGCAGGTGCTCAAAT
CCACTTGACACATCAGTGAAGGAGAAAATATCAATGTTCTGCCATGTTGAGCCTGAACAA
GTGATCTGTGTCCACGATGTCTCATCCATCTACCGAGTCCCCTTGTTGTTAGAGGAGCAA
GGGGTTGTAGATTATTTTCTTCGAAGACTTGACCTTCCTATTGAGAGGCAGCCAAGAAAA
ATGCTGATGAAATGGAAAGAGATGGCTGACAGATATGATCGCTTGCTGGAGACCTGCTCT
ATTGCCCTTGTGGCGAAATACACCGAGTTCTCAGACTCCTATGCCTCTGTCATTAAGGCT
CTGGAGCATTCTGCACTGGCCATCAACCACAAATTGGAAATCAAGTACATAGATTCTGCG
GACTTGGAGCCCATCACCTCGCAAGAAGAGCCCGTGCGCTACCACGAAGCTTGGCAGAAG
CTCTGTAGTGCTCATGGAGTGCTGGTTCCAGGAGGATTTGGTGTTCGAGGAACAGAAGGA
AAAATCCAAGCAATTGCCTGGGCTCGGAATCAGAAAAAGCCTTTTTTGGGCGTGTGCTTA
GGGATGCAGTTGGCAGTGGTTGAATTCTCAAGAAACGTGCTGGGATGGCAAGATGCCAAT
TCTACAGAGTTTGACCCTACGACCAGTCATCCCGTGGTCGTAGACATGCCAGAACACAAC
CCAGGGCAGATGGGCGGAACCATGAGGCTGGGCAAGAGGAGAACCCTGTTCCAGACCAAG
AACTCAGTCATGAGGAAACTCTATGGAGACGCAGACTACTTGGAAGAGAGGCACCGCCAC
CGATTTGAGGTGAATCCAGTCTGGAAAAAGTGTTTGGAAGAACAAGGCTTGAAGTTTGTT
GGCCAAGATGTTGAAGGAGAGAGAATGGAAATTGTGGAGTTAGAAGATCATCCCTTTTTT
GTTGGGGTTCAGTACCACCCTGAGTTCCTGTCCAGGCCTATCAAGCCCTCCCCACCATAC
TTTGGCCTCCTCCTGGCCTCTGTGGGGCGGCTCTCACATTACCTCCAGAAAGGCTGCAGG
CTCTCACCCAGGGACACCTATAGTGACAGGAGTGGAAGCAGCTCCCCTGACTCTGAAATC
ACCGAACTGAAGTTTCCATCAATAAATCATGACTGA

# Metabolic_Enzyme_23_GenBank_ID_Gene:
X52142

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_23_Locus:
1p34.1

# Metabolic_Enzyme_23_SNPs:
rs4363414; rs16827810; rs7546898; rs11577910; rs11209315; rs7512775; rs12410005; rs12410096; rs12718433; rs11209342; rs12408576; rs4132438; rs6600363; rs4132440; rs7523029; rs6600362; rs7535802; rs11209331; rs3922676; rs4364871; rs7537689; rs4453027; rs12047657; rs12044786; rs35044078; rs4430318; rs12735455; rs12743340; rs13376450; rs12731155; rs4132439; rs12144160; rs11209347; rs12047078; rs12023079; rs2897231; rs2897230; rs12729920; rs3935871; rs35240983; rs17856308; rs11541594; rs36007898; rs34761170; rs5030799; rs33963815; rs11316628; rs12736067; rs5030801; rs35846227; rs34730648; rs5030800; rs7543690; rs11209312; rs4130828; rs12135912; rs6675122; rs12145744; rs12749196; rs34316011; rs34538426; rs12135364; rs35080169; rs34043964; rs35160190; rs12119675; rs4660497; rs5773721; rs35156226; rs35281195; rs28469640; rs11209349; rs12027691; rs4660496; rs12739052; rs4660182; rs11580414; rs35368773; rs34472412; rs41308258; rs11343566; rs28401673; rs34502739; rs12748235; rs6675165; rs12061505; rs34406683; rs4548429; rs36057096; rs41268101; rs12738189; rs12724936; rs12090358; rs1892553; rs12079825; rs12132595; rs3206609; rs34209541; rs10789262; rs11209361; rs11209363; rs1129661; rs1138293; rs11579483; rs11579485; rs11584051; rs12033893; rs12033917; rs12033920; rs12121539; rs12736566; rs17357905; rs17357954; rs34386830; rs35405087; rs36084778; rs3738368; rs3738369; rs4360513; rs4440845; rs4660498; rs6661890; rs6674450; rs6685430; rs7534059

# Metabolic_Enzyme_23_General_References:
2113467

# Metabolic_Enzyme_23_References:
Not Available

# Metabolic_Enzyme_24_ID:
5950

# Metabolic_Enzyme_24_Name:
Protein-arginine deiminase type-3

# Metabolic_Enzyme_24_Synonyms:
Protein-arginine deiminase type III; Peptidylarginine deiminase III

# Metabolic_Enzyme_24_Gene_Name:
PADI3

# Metabolic_Enzyme_24_Protein_Sequence:
>Proteinarginine deiminase type3
MSLQRIVRVSLEHPTSAVCVAGVETLVDIYGSVPEGTEMFEVYGTPGVDIYISPNMERGR
ERADTRRWRFDATLEIIVVMNSPSNDLNDSHVQISYHSSHEPLPLAYAVLYLTCVDISLD
CDLNCEGRQDRNFVDKRQWVWGPSGYGGILLVNCDRDDPSCDVQDNCDQHVHCLQDLEDM
SVMVLRTQGPAALFDDHKLVLHTSSYDAKRAQVFHICGPEDVCEAYRHVLGQDKVSYEVP
RLHGDEERFFVEGLSFPDAGFTGLISFHVTLLDDSNEDFSASPIFTDTVVFRVAPWIMTP
STLPPLEVYVCRVRNNTCFVDAVAELARKAGCKLTICPQAENRNDRWIQDEMELGYVQAP
HKTLPVVFDSPRNGELQDFPYKRILGPDFGYVTREPRDRSVSGLDSFGNLEVSPPVVANG
KEYPLGRILIGGNLPGSSGRRVTQVVRDFLHAQKVQPPVELFVDWLAVGHVDEFLSFVPA
PDGKGFRMLLASPGACFKLFQEKQKCGHGRALLFQGVVDDEQVKTISINQVLSNKDLINY
NKFVQSCIDWNREVLKRELGLAECDIIDIPQLFKTERKKATAFFPDLVNMLVLGKHLGIP
KPFGPIINGCCCLEEKVRSLLEPLGLHCTFIDDFTPYHMLHGEVHCGTNVCRKPFSFKWW
NMVP

# Metabolic_Enzyme_24_Number_of_Residues:
664

# Metabolic_Enzyme_24_Molecular_Weight:
74744

# Metabolic_Enzyme_24_Theoretical_pI:
5.22

# Metabolic_Enzyme_24_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Function:  protein-arginine deiminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_24_General_Function:
Not Available

# Metabolic_Enzyme_24_Specific_Function:
Catalyzes the deimination of arginine residues of proteins

# Metabolic_Enzyme_24_Pathway:
Not Available

# Metabolic_Enzyme_24_Reaction:
protein L-arginine + H2O = protein L-citrulline + NH3

# Metabolic_Enzyme_24_Pfam_Domain_Function:
PF03068:PAD;
PF08527:PAD_M;
PF08526:PAD_N

# Metabolic_Enzyme_24_Signals:
None

# Metabolic_Enzyme_24_Transmembrane_Regions:
None

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 3.5.3.15

# Metabolic_Enzyme_24_GenBank_ID_Protein:
6172379

# Metabolic_Enzyme_24_SwissProt_ID:
PADI3_HUMAN (Q9ULW8)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
PADI3

# Metabolic_Enzyme_24_Geneatlas_id:
PADI3

# Metabolic_Enzyme_24_hgnc_id:
HGNC:18337

# Metabolic_Enzyme_24_PDB_ID:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_24_Gene_Sequence:
>1995 bp
ATGTCGCTGCAGAGAATCGTGCGTGTGTCCCTGGAGCATCCCACCAGCGCGGTGTGTGTG
GCTGGCGTGGAGACCCTCGTGGACATTTATGGGTCAGTGCCTGAGGGCACAGAAATGTTT
GAGGTCTATGGGACGCCTGGCGTGGACATCTACATCTCTCCCAACATGGAGAGGGGCCGG
GAGCGTGCAGACACCAGGCGGTGGCGCTTTGACGCGACTTTGGAGATCATCGTGGTCATG
AACTCCCCCAGCAATGACCTCAACGACAGCCATGTTCAGATTTCCTACCACTCCAGCCAT
GAGCCTCTGCCCCTAGCCTATGCGGTGCTCTACCTCACCTGTGTTGACATCTCTCTGGAT
TGCGACCTGAACTGTGAGGGAAGGCAGGACAGGAACTTTGTAGACAAGCGGCAGTGGGTC
TGGGGGCCCAGTGGGTATGGCGGCATCTTGCTGGTGAACTGTGACCGTGATGATCCGAGC
TGTGATGTCCAGGACAATTGTGACCAGCACGTGCACTGCCTGCAAGACCTGGAAGACATG
TCTGTCATGGTCCTGCGGACGCAGGGCCCTGCAGCCCTCTTTGATGACCACAAACTTGTC
CTCCATACCTCCAGCTATGATGCCAAACGGGCACAGGTCTTCCACATCTGCGGTCCTGAG
GATGTGTGTGAGGCCTATAGGCATGTGCTGGGCCAAGATAAGGTGTCCTATGAGGTACCC
CGCTTGCATGGGGATGAGGAGCGCTTCTTCGTGGAAGGCCTGTCCTTCCCTGATGCCGGC
TTCACAGGACTCATCTCCTTCCATGTCACTCTGCTGGACGACTCCAACGAGGATTTCTCG
GCATCCCCTATCTTCACTGACACTGTGGTGTTCCGAGTGGCACCCTGGATCATGACGCCC
AGCACTCTGCCACCCCTAGAGGTGTATGTGTGCCGTGTGAGGAACAACACGTGTTTTGTG
GATGCGGTGGCAGAGCTGGCCAGGAAGGCCGGCTGCAAGCTGACCATCTGCCCACAGGCC
GAGAACCGCAACGACCGCTGGATCCAGGATGAGATGGAGCTGGGCTACGTTCAGGCGCCG
CACAAGACCCTCCCGGTGGTCTTTGACTCCCCAAGGAATGGGGAACTGCAGGATTTCCCT
TACAAAAGAATCCTGGGTCCAGATTTTGGTTACGTGACTCGGGAACCACGCGACAGGTCT
GTGAGTGGCCTGGACTCCTTTGGGAACCTGGAGGTCAGCCCTCCAGTGGTGGCCAATGGG
AAAGAGTACCCCCTGGGGAGGATCCTCATTGGGGGCAACCTGCCTGGGTCAAGTGGCCGC
AGGGTCACCCAGGTGGTGCGGGACTTCCTCCATGCCCAGAAGGTGCAGCCCCCCGTGGAG
CTCTTTGTGGACTGGTTGGCCGTGGGCCATGTGGATGAGTTTCTGAGCTTTGTCCCTGTC
CCCGATGGGAAGGGCTTCCGGATGCTCCTGGCCAGCCCTGGGGCCTGCTTCAAGCTCTTC
CAGGAAAAGCAGAAGTGTGGCCACGGGAGGGCCCTCCTGTTCCAGGGGGTTGTTGATGAT
GAGCAGGTCAAGACCATCTCCATCAACCAGGTGCTCTCCAATAAAGACCTCATCAACTAC
AATAAGTTTGTGCAGAGCTGCATCGACTGGAACCGTGAGGTGCTGAAGCGGGAGCTGGGC
CTGGCAGAGTGTGACATCATTGACATCCCACAGCTCTTCAAGACCGAGAGGAAAAAAGCA
ACGGCCTTCTTCCCTGACTTGGTGAACATGCTGGTGCTGGGGAAGCACCTGGGCATCCCC
AAGCCCTTTGGGCCCATCATCAATGGCTGCTGCTGCCTGGAGGAGAAGGTGCGGTCCCTG
CTGGAGCCTCTGGGCCTCCACTGCACCTTCATTGATGACTTCACTCCATACCACATGCTG
CATGGGGAGGTGCACTGTGGCACCAATGTGTGCAGAAAGCCCTTCTCTTTCAAGTGGTGG
AACATGGTGCCCTGA

# Metabolic_Enzyme_24_GenBank_ID_Gene:
AB026831

# Metabolic_Enzyme_24_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_24_Locus:
1p36.13

# Metabolic_Enzyme_24_SNPs:
rs2272629; rs3750300; rs34097903; rs35624745; rs2293916; rs11585357; rs2293920; rs11584781; rs3763589; rs2977300; rs2977301; rs16824888; rs12135399; rs3750303; rs17424382; rs2977229; rs2977230; rs3003434; rs2977269; rs2977228; rs4920579; rs3003423; rs3003435; rs3003440; rs4363467; rs2977293; rs10888013; rs6673643; rs4920361; rs2977262; rs6586512; rs3003438; rs4462198; rs2272630; rs10888012; rs4920362; rs11203343; rs7522439; rs4920580; rs3003429; rs2293917; rs12025184; rs2977295; rs2977299; rs12562867; rs4339902; rs2272628; rs2272627; rs6682638; rs2977264; rs3753375; rs12566659; rs3003424; rs4920585; rs11586393; rs10492991; rs3890176; rs2977292; rs4595409; rs17424167; rs11585119; rs11802379; rs4920584; rs11584287; rs17458091; rs11585118; rs4920582; rs3766301; rs3003426; rs3003432; rs6679788; rs12044550; rs9803868; rs16824388; rs11203346; rs11803680; rs3829052; rs3766298; rs2977296; rs12070008; rs3003427; rs11587458; rs4920360; rs3900818; rs2977227; rs11588043; rs2977268; rs3003428; rs12037653; rs3003436; rs2977266; rs2977294; rs4920581; rs17458002; rs7531565; rs16824578; rs12058442; rs4262593; rs12035310; rs17378462; rs3003437; rs12135984; rs3003425; rs13374860; rs4920583; rs12037558; rs16824705; rs11203345; rs3003439; rs12125585; rs16824443; rs4920578; rs16824389; rs4262594; rs3003433; rs12077122; rs7520753; rs16824440; rs3750304; rs2977226; rs3003419; rs2977302; rs12404500; rs3003421; rs3763587; rs2293918; rs12032160; rs34341567; rs3003430; rs35340855; rs34177351; rs12744056; rs12743888; rs35974923; rs12079310; rs3835470; rs13374866; rs3215408; rs35100768; rs34837071; rs12077035; rs12032104; rs35532821; rs12729982; rs34316986; rs34397530; rs10617336; rs36049065; rs12035084; rs3003422; rs2977297; rs35152903; rs34668130; rs12077117; rs34173303; rs12730111; rs2977267; rs3003431; rs6669280; rs13374868; rs2977298; rs36000793; rs28504120; rs12072671; rs35179407; rs12730112; rs35198407; rs12133221; rs5772753; rs2293919; rs35886575; rs4451590; rs34916627; rs28493448; rs11274291; rs12065629; rs12135460; rs11426940; rs11581115; rs34487635; rs12034584; rs35385289; rs7545176; rs34826223; rs12127898; rs35397237; rs3003420; rs34745182; rs10492990; rs11577718; rs11587669; rs11588418; rs11808782; rs12043098; rs12073445; rs12119803; rs12129306; rs12568771; rs12725491; rs16824215; rs2293921; rs2501776; rs2977222; rs2977223; rs2977224; rs2977225; rs2977303; rs2977304; rs2977305; rs2977311; rs2977312; rs2977313; rs3003414; rs3003445; rs3123529; rs3750299; rs735280; rs735281; rs745339; rs745340

# Metabolic_Enzyme_24_General_References:
11069618

# Metabolic_Enzyme_24_References:
Not Available

# Metabolic_Enzyme_25_ID:
5951

# Metabolic_Enzyme_25_Name:
GMP reductase 2

# Metabolic_Enzyme_25_Synonyms:
Guanosine 5'-monophosphate oxidoreductase 2; Guanosine monophosphate reductase 2

# Metabolic_Enzyme_25_Gene_Name:
GMPR2

# Metabolic_Enzyme_25_Protein_Sequence:
>GMP reductase 2
MPHIDNDVKLDFKDVLLRPKRSTLKSRSEVDLTRSFSFRNSKQTYSGVPIIAANMDTVGT
FEMAKVLCKFSLFTAVHKHYSLVQWQEFAGQNPDCLEHLAASSGTGSSDFEQLEQILEAI
PQVKYICLDVANGYSEHFVEFVKDVRKRFPQHTIMAGNVVTGEMVEELILSGADIIKVGI
GPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVM
LGGMLAGHSESGGELIERDGKKYKLFYGMSSEMAMKKYAGGVAEYRASEGKTVEVPFKGD
VEHTIRDILGGIRSTCTYVGAAKLKELSRRTTFIRVTQQVNPIFSEAC

# Metabolic_Enzyme_25_Number_of_Residues:
348

# Metabolic_Enzyme_25_Molecular_Weight:
37875

# Metabolic_Enzyme_25_Theoretical_pI:
7.25

# Metabolic_Enzyme_25_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on NADH or NADPH
Function:  oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor
Function:  GMP reductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_25_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_25_Specific_Function:
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation

# Metabolic_Enzyme_25_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_25_Reaction:
inosine 5'-phosphate + ammonia + NADP+ = guanosine 5'-phosphate + NADPH + H+

# Metabolic_Enzyme_25_Pfam_Domain_Function:
PF00478:IMPDH

# Metabolic_Enzyme_25_Signals:
None

# Metabolic_Enzyme_25_Transmembrane_Regions:
None

# Metabolic_Enzyme_25_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_25_EC_Link:
EC 1.7.1.7

# Metabolic_Enzyme_25_GenBank_ID_Protein:
23451216

# Metabolic_Enzyme_25_SwissProt_ID:
GMPR2_HUMAN (Q9P2T1)

# Metabolic_Enzyme_25_swissprot_Name:
Not Available

# Metabolic_Enzyme_25_Genecard_id:
GMPR2

# Metabolic_Enzyme_25_Geneatlas_id:
GMPR2

# Metabolic_Enzyme_25_hgnc_id:
HGNC:4377

# Metabolic_Enzyme_25_PDB_ID:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_25_Subcellular_Location:
Not Available

# Metabolic_Enzyme_25_Gene_Sequence:
>1047 bp
ATGCCTCATATTGACAACGATGTGAAACTGGACTTCAAGGATGTCCTTTTGAGGCCCAAA
CGCAGTACCCTTAAGTCTCGAAGTGAGGTGGATCTCACAAGATCCTTTTCATTTCGGAAC
TCAAAGCAGACATACTCTGGGGTTCCCATCATTGCTGCCAATATGGATACTGTGGGCACC
TTTGAGATGGCCAAGGTTCTCTGTAAGTTCTCTCTCTTCACTGCTGTCCATAAGCACTAT
AGCCTCGTTCAGTGGCAAGAGTTTGCTGGCCAGAATCCTGACTGTCTTGAGCATCTGGCT
GCCAGCTCAGGCACAGGCTCTTCTGACTTTGAGCAGCTGGAACAGATCCTGGAAGCTATT
CCCCAGGTGAAGTATATATGCCTGGATGTGGCAAATGGCTACTCTGAACACTTTGTTGAA
TTTGTAAAAGATGTACGGAAGCGCTTCCCCCAGCACACCATCATGGCAGGGAATGTGGTA
ACAGGAGAGATGGTAGAAGAGCTCATCCTTTCTGGGGCTGACATCATCAAAGTGGGAATT
GGGCCAGGCTCTGTGTGTACTACTCGGAAGAAAACTGGAGTGGGGTATCCACAGCTCAGC
GCAGTGATGGAGTGTGCAGATGCTGCTCATGGCCTCAAAGGCCACATCATTTCAGATGGA
GGTTGCAGCTGTCCTGGGGATGTGGCCAAGGCTTTTGGGGCAGGAGCTGACTTCGTGATG
CTGGGTGGCATGCTGGCTGGGCACAGTGAGTCAGGTGGTGAGCTCATCGAGAGGGATGGC
AAGAAGTACAAGCTCTTCTATGGAATGAGTTCTGAAATGGCCATGAAGAAGTATGCTGGG
GGCGTGGCTGAGTACAGAGCCTCAGAGGGAAAGACAGTGGAAGTTCCTTTTAAAGGAGAT
GTGGAACATACCATCCGAGACATCCTAGGAGGGATCCGCTCTACGTGTACCTATGTGGGA
GCAGCTAAGCTCAAAGAGTTGAGCAGGAGAACTACCTTCATCCGAGTCACCCAGCAGGTG
AATCCAATCTTCAGTGAGGCGTGCTAG

# Metabolic_Enzyme_25_GenBank_ID_Gene:
AF419346

# Metabolic_Enzyme_25_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_25_Locus:
14q12

# Metabolic_Enzyme_25_SNPs:
rs34354104; rs2273304; rs12891162; rs17102265; rs1950496; rs2273305; rs11540864; rs1142733; rs17102232; rs4624073; rs34469605; rs1950495; rs10134804; rs10138628; rs10141326; rs10148135; rs11158615; rs11625433; rs11844422; rs12883582; rs12897704; rs17102177; rs17102311; rs17102313; rs17794752; rs2144487; rs2295316; rs2332229; rs34113897; rs3814815; rs4982877; rs7145550; rs7152342; rs7157595; rs7158744; rs766601; rs766602; rs8193035

# Metabolic_Enzyme_25_General_References:
12009299

# Metabolic_Enzyme_25_References:
Not Available

# Metabolic_Enzyme_26_ID:
5594

# Metabolic_Enzyme_26_Name:
Porphobilinogen deaminase

# Metabolic_Enzyme_26_Synonyms:
Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase; PBG-D

# Metabolic_Enzyme_26_Gene_Name:
HMBS

# Metabolic_Enzyme_26_Protein_Sequence:
>Porphobilinogen deaminase
MSGNGNAAATAEENSPKMRVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTG
DKILDTALSKIGEKSLFTKELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPH
DAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQ
QEFSAIILATAGLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHD
PETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIH
VPAQHEDGPEDDPQLVGITARNIPRGPQLAAQNLGISLANLLLSKGAKNILDVARQLNDA
H

# Metabolic_Enzyme_26_Number_of_Residues:
361

# Metabolic_Enzyme_26_Molecular_Weight:
39331

# Metabolic_Enzyme_26_Theoretical_pI:
7.19

# Metabolic_Enzyme_26_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  hydroxymethylbilane synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  heterocycle metabolism
Process:  porphyrin metabolism
Process:  porphyrin biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_26_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_26_Specific_Function:
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

# Metabolic_Enzyme_26_Pathway:
map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_26_Reaction:
4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3

# Metabolic_Enzyme_26_Pfam_Domain_Function:
PF01379:Porphobil_deam;
PF03900:Porphobil_deamC

# Metabolic_Enzyme_26_Signals:
None

# Metabolic_Enzyme_26_Transmembrane_Regions:
None

# Metabolic_Enzyme_26_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_26_EC_Link:
EC 2.5.1.61

# Metabolic_Enzyme_26_GenBank_ID_Protein:
35307

# Metabolic_Enzyme_26_SwissProt_ID:
HEM3_HUMAN (P08397)

# Metabolic_Enzyme_26_swissprot_Name:
Not Available

# Metabolic_Enzyme_26_Genecard_id:
HMBS

# Metabolic_Enzyme_26_Geneatlas_id:
HMBS

# Metabolic_Enzyme_26_hgnc_id:
HGNC:4982

# Metabolic_Enzyme_26_PDB_ID:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_26_Subcellular_Location:
Cytoplasm (Probable)

# Metabolic_Enzyme_26_Gene_Sequence:
>1035 bp
ATGAGAGTGATTCGCGTGGGTACCCGCAAGAGCCAGCTTGCTCGCATACAGACGGACAGT
GTGGTGGCAACATTGAAAGCCTCGTACCCTGGCCTGCAGTTTGAAATCATTGCTATGTCC
ACCACAGGGGACAAGATTCTTGATACTGCACTCTCTAAGATTGGAGAGAAAAGCCTGTTT
ACCAAGGAGCTTGAACATGCCCTGGAGAAGAATGAAGTGGACCTGGTTGTTCACTCCTTG
AAGGACCTGCCCACTGTGCTTCCTCCTGGCTTCACCATCGGAGCCATCTGCAAGCGGGAA
AACCCTCATGATGCTGTTGTCTTTCACCCAAAATTTGTTGGGAAGACCCTAGAAACCCTG
CCAGAGAAGAGTGTGGTGGGAACCAGCTCCCTGCGAAGAGCAGCCCAGCTGCAGAGAAAG
TTCCCGCATCTGGAGTTCAGGAGTATTCGGGGAAACCTCAACACCCGGCTTCGGAAGCTG
GACGAGCAGCAGGAGTTCAGTGCCATCATCCTAGCAACAGCTGGCCTGCAGCGCATGGGC
TGGCACAACCGGGTTGGGCAGATCCTGCACCCTGAGGAATGCATGTATGCTGTGGGCCAG
GGGGCCTTGGGCGTGGAAGTGCGAGCCAAGGACCAGGACATCTTGGATCTGGTGGGTGTG
CTGCACGATCCCGAGACTCTGCTTCGCTGCATCGCTGAAAGGGCCTTCCTGAGGCACCTG
GAAGGAGGCTGCAGTGTGCCAGTAGCCGTGCATACAGCTATGAAGGATGGGCAACTGTAC
CTGACTGGAGGAGTCTGGAGTCTAGACGGCTCAGATAGCATACAAGAGACCATGCAGGCT
ACCATCCATGTCCCTGCCCAGCATGAAGATGGCCCTGAGGATGACCCACAGTTGGTAGGC
ATCACTGCTCGTAACATTCCACGAGGGCCCCAGTTGGCTGCCCAGAACTTGGGCATCAGC
CTGGCCAACTTGTTGCTGAGCAAAGGAGCCAAAACCATCCTGGATGTTGCACGGCAGCTT
AACGATGCCCATTAA

# Metabolic_Enzyme_26_GenBank_ID_Gene:
X04217

# Metabolic_Enzyme_26_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_26_Locus:
11q23.3

# Metabolic_Enzyme_26_SNPs:
rs1131488; rs1006195; rs589925; rs1784304; rs17075; rs616314; rs474201; rs11602791; rs28990985; rs494048; rs28990987; rs1799993; rs28990986; rs686624; rs592190; rs7479337; rs7952700; rs7952138; rs7938944; rs7942647; rs7924387; rs694328; rs11544979; rs34413634; rs762585; rs1051074; rs11544980; rs557253; rs28990984; rs1144041; rs1145225; rs35779756; rs2846282; rs34850583; rs2515706; rs4373940; rs7942009; rs7927752; rs11217149; rs549893; rs1799991; rs4272791; rs10618931; rs1799992; rs622846; rs12576807; rs1799994; rs34984714; rs11297272; rs12270687; rs34104555; rs4938625; rs11217148; rs4415775; rs35441227; rs35730078; rs34378932; rs34854067; rs603423; rs35182632; rs685241; rs1046374; rs1046375; rs1064180; rs1064193; rs10790282; rs1168568; rs1177562; rs1177563; rs1307145; rs15301; rs15818; rs1786687; rs1799997; rs2508948; rs2509049; rs2509704; rs2509850; rs28990980; rs3204606; rs34757931; rs35871971; rs36008744; rs3824944; rs4614; rs540261; rs565669; rs640603; rs643788; rs649870; rs7122226; rs7127212; rs7350; rs7759; rs8551

# Metabolic_Enzyme_26_General_References:
2875434; 3816774; 7916736; 3422427; 2609111; 7866402; 2243128; 1714233; 1496994; 1427766; 1301948; 8262523; 8401516; 8268934; 8270254; 8270256; 8081367; 7962538; 7757070; 8825929; 9199558; 9225970; 9654202; 9463797; 10494093; 10453740; 10502788; 10657149; 11030413; 10782018; 11013452

# Metabolic_Enzyme_26_References:
Not Available

# Metabolic_Enzyme_27_ID:
5952

# Metabolic_Enzyme_27_Name:
Protein-glutamine gamma-glutamyltransferase 5

# Metabolic_Enzyme_27_Synonyms:
Transglutaminase-5; TGase 5; Transglutaminase X; TGase X; TGX; TG(X

# Metabolic_Enzyme_27_Gene_Name:
TGM5

# Metabolic_Enzyme_27_Protein_Sequence:
>Proteinglutamine gammaglutamyltransferase 5
MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV
VETGPLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIH
IDSFQGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCP
WNYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNG
NWSENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVIT
NFDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLD
ATPQEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDT
SSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQP
SRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLK
VNLSAQSLLHDGSPLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALG
EEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGS
GLFKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL


# Metabolic_Enzyme_27_Number_of_Residues:
720

# Metabolic_Enzyme_27_Molecular_Weight:
80778

# Metabolic_Enzyme_27_Theoretical_pI:
6.39

# Metabolic_Enzyme_27_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  peptide cross-linking
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_27_General_Function:
Not Available

# Metabolic_Enzyme_27_Specific_Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes

# Metabolic_Enzyme_27_Pathway:
Not Available

# Metabolic_Enzyme_27_Reaction:
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3

# Metabolic_Enzyme_27_Pfam_Domain_Function:
PF00927:Transglut_C;
PF01841:Transglut_core;
PF00868:Transglut_N

# Metabolic_Enzyme_27_Signals:
None

# Metabolic_Enzyme_27_Transmembrane_Regions:
None

# Metabolic_Enzyme_27_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_27_EC_Link:
EC 2.3.2.13

# Metabolic_Enzyme_27_GenBank_ID_Protein:
2895530

# Metabolic_Enzyme_27_SwissProt_ID:
TGM5_HUMAN (O43548)

# Metabolic_Enzyme_27_swissprot_Name:
Not Available

# Metabolic_Enzyme_27_Genecard_id:
TGM5

# Metabolic_Enzyme_27_Geneatlas_id:
TGM5

# Metabolic_Enzyme_27_hgnc_id:
HGNC:11781

# Metabolic_Enzyme_27_PDB_ID:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_27_Subcellular_Location:
Cytoplasm. Note=Associated with intermediate filaments

# Metabolic_Enzyme_27_Gene_Sequence:
>2163 bp
ATGGCCCAAGGGCTAGAAGTGGCCCTCACAGACCTCCAGAGCTCCAGAAATAATGTGCGG
CACCACACGGAGGAGATCACTGTGGACCACCTGCTTGTTCGCCGGGGCCAGGCCTTCAAC
CTCACCCTGTACTTCAGGAACCGGAGCTTCCAGCCAGGCCTGGACAACATCATCTTCGTG
GTTGAAACTGGACCGCTGTCAGACCTGGCCTTGGGGACTCGGGCTGTGTTCAGCCTGGCA
CGCCATCACAGCCCCAGCCCCTGGATTGCCTGGCTGGAGACCAATGGGGCCACCTCCACA
GAGGTGAGCTTGTGCGCTCCTCCCACGGCGGCCGTGGGTCGGTACCTCTTGAAAATCCAC
ATCGACTCCTTCCAGGGGTCTGTGACGGCCTACCAGCTAGGGGAGTTCATCCTGCTTTTC
AATCCCTGGTGCCCAGAGGATGCTGTCTACTTGGACAGTGAACCCCAGAGGCAGGAGTAT
GTCATGAATGATTATGGCTTCATCTACCAAGGCAGCAAGAACTGGATCCGCCCATGTCCC
TGGAACTATGGACAGTTTGAAGACAAAATCATAGACATCTGCCTGAAGCTGCTAGACAAG
AGCCTGCACTTCCAGACTGACCCAGCCACAGACTGTGCTCTGCGGGGAAGCCCCGTCTAC
GTCAGCAGAGTGGTGTGTGCCATGATCAACAGCAATGATGATAATGGGGTGCTCAATGGA
AACTGGAGTGAGAATTACACAGACGGCGCCAACCCTGCGGAGTGGACGGGCAGCGTGGCC
ATCCTGAAGCAGTGGAACGCCACAGGCTGCCAGCCCGTGCGCTACGGGCAATGCTGGGTC
TTTGCTGCCGTCATGTGCACAGTGATGAGGTGTCTGGGGATCCCTACCCGTGTGATCACC
AACTTCGACTCTGGCCACGATACAGATGGAAACCTGATCATAGATGAGTATTATGACAAC
ACAGGCAGGATTTTGGGGAATAAGAAGAAGGATACTATCTGGAACTTCCATGTCTGGAAT
GAGTGCTGGATGGCCCGGAAGGATCTGCCCCCTGCATATGGAGGCTGGCAGGTGCTGGAC
GCCACACCTCAGGAGATGAGCAACGGCGTCTACTGCTGTGGCCCTGCCTCTGTCAGAGCC
ATCAAAGAAGGAGAAGTGGACCTGAACTATGACACGCCCTTTGTGTTTTCGATGGTGAAT
GCTGACTGCATGTCCTGGCTCGTCCAGGGAGGGAAGGAGCAGAAGCTTCACCAGGACACG
AGTTCTGTTGGCAATTTTATCAGCACAAAGAGCATCCAGAGTGACGAGCGGGATGACATC
ACAGAGAACTACAAGTATGAAGAAGGATCCCTCCAGGAGAGGCAGGTGTTTCTGAAGGCT
CTGCAGAAGCTGAAGGCTAGAAGCTTCCATGGCTCCCAAAGAGGAGCAGAGTTGCAACCT
TCCAGGCCCACATCACTGAGCCAGGACAGCCCTCGGAGCCTGCATACACCTTCCCTTCGA
CCCAGTGATGTGGTGCAAGTCTCCCTGAAATTCAAGCTGCTCGACCCGCCCAACATGGGC
CAGGATATATGCTTTGTCCTGCTGGCCCTCAACATGTCCTCCCAGTTCAAGGACCTCAAA
GTGAACCTGAGTGCCCAGTCTCTGCTGCACGATGGCAGCCCCCTGTCCCCATTCTGGCAG
GACACAGCGTTCATCACACTCTCTCCTAAAGAAGCAAAGACCTACCCCTGCAAAATCTCC
TATTCCCAGTACAGCCAGTACCTGTCAACAGACAAGCTGATCCGCATCAGTGCCCTGGGT
GAAGAGAAAAGCAGTCCTGAGAAAATCCTGGTGAACAAGATCATCACCTTATCTTATCCA
AGCATCACGATTAATGTTCTAGGAGCAGCCGTTGTGAACCAGCCACTCTCCATACAGGTG
ATATTTTCAAACCCCCTCTCGGAGCAGGTTGAGGACTGTGTGCTGACTGTGGAAGGAAGT
GGCCTCTTCAAGAAACAGCAGAAAGTCTTCCTTGGAGTCCTCAAACCCCAACACCAAGCA
AGCATCATTCTGGAGACCGTCCCCTTCAAGAGTGGACAAAGGCAGATCCAAGCTAATATG
AGAAGCAACAAGTTTAAGGACATTAAGGGTTACAGGAATGTTTATGTAGACTTTGCATTA
TAA

# Metabolic_Enzyme_27_GenBank_ID_Gene:
AF035960

# Metabolic_Enzyme_27_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_27_Locus:
15q15.2

# Metabolic_Enzyme_27_SNPs:
rs7171797; rs28756768; rs35985214; rs555001; rs34222269; rs502157; rs471122; rs542036; rs525403; rs574065; rs504417; rs545430; rs501884; rs579651; rs475261; rs530188; rs475227; rs493177; rs11070398; rs524547; rs16957507; rs825735; rs579178; rs16957511; rs573201; rs512431; rs572959; rs7183814; rs11855754; rs2241516; rs11853991; rs473016; rs16957502; rs565658; rs560134; rs3784267; rs7162827; rs12592795; rs3784268; rs564946; rs16957519; rs17778967; rs554001; rs573169; rs12909095; rs526292; rs16957521; rs752958; rs9652444; rs748404; rs11070397; rs7176183; rs513815; rs35578968; rs28465532; rs2241517; rs35025462; rs34973909; rs12901716; rs28544171; rs36041994; rs34646108; rs34092345; rs28705146; rs34978919; rs12911928; rs35535692; rs28444219; rs35852478; rs11430059; rs28505576; rs28670888; rs7162620; rs28669912; rs28445909; rs34922681; rs28393739; rs2412764; rs521681; rs12902267; rs34448188; rs28467179; rs34425851; rs34224662; rs34434330; rs12911633; rs13329564; rs34398515; rs34787120; rs34700701; rs34151953; rs34898259; rs2277527; rs34362734; rs35794888; rs11070396; rs12592725; rs12915538; rs2577057; rs28377745; rs35460126; rs35891068; rs3759788; rs473554; rs489964; rs491804; rs492743; rs493444; rs505249; rs530683; rs531910; rs537102; rs573774; rs6493080

# Metabolic_Enzyme_27_General_References:
9452468; 11390390

# Metabolic_Enzyme_27_References:
Not Available

# Metabolic_Enzyme_28_ID:
5953

# Metabolic_Enzyme_28_Name:
Glutaminase kidney isoform, mitochondrial precursor

# Metabolic_Enzyme_28_Synonyms:
GLS; L-glutamine amidohydrolase; K-glutaminase

# Metabolic_Enzyme_28_Gene_Name:
GLS

# Metabolic_Enzyme_28_Protein_Sequence:
>Glutaminase kidney isoform, mitochondrial precursor
MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVE
VVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQT
VHKNLDGLL

# Metabolic_Enzyme_28_Number_of_Residues:
669

# Metabolic_Enzyme_28_Molecular_Weight:
73462

# Metabolic_Enzyme_28_Theoretical_pI:
7.82

# Metabolic_Enzyme_28_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Function:  glutaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_28_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_28_Specific_Function:
Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine

# Metabolic_Enzyme_28_Pathway:
map00251  Glutamate metabolism;
 map00471  D-Glutamine and D-glutamate metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_28_Reaction:
L-glutamine + H2O = L-glutamate + NH3

# Metabolic_Enzyme_28_Pfam_Domain_Function:
PF00023:Ank;
PF04960:Glutaminase

# Metabolic_Enzyme_28_Signals:
1-23

# Metabolic_Enzyme_28_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_28_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_28_EC_Link:
EC 3.5.1.2

# Metabolic_Enzyme_28_GenBank_ID_Protein:
5690372

# Metabolic_Enzyme_28_SwissProt_ID:
GLSK_HUMAN (O94925)

# Metabolic_Enzyme_28_swissprot_Name:
Not Available

# Metabolic_Enzyme_28_Genecard_id:
GLS

# Metabolic_Enzyme_28_Geneatlas_id:
GLS

# Metabolic_Enzyme_28_hgnc_id:
HGNC:4331

# Metabolic_Enzyme_28_PDB_ID:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_28_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_28_Gene_Sequence:
>1797 bp
ATGATGCGGCTGCGAGGCTCGGGGATGCTGCGGGACCTGCTCCTGCGGTCGCCCGCCGGC
GTGAGCGNGACTCTGCGGCGGGCACAGCCCTTGGTCACCCTGTGCCGGCGTCCCCGAGGC
GGGGGACGGCCGGCCGCGGGCCCGGCTGCCGCCGCGCGACTCCACCCGTGGTGGGGCGGG
GGCGGCTGGCCGGCGGAGCCCCTCGCGCGGGGCCTGTCCAGCTCTCCTTCGGAGATCTTG
CAGGAGCTGGGCAAGGGGAGCACGCATCCCCAGCCCGGGGTGTCGCCACCCGCTGCCCCG
GCGGCGCCCGGCCCCAAGGACGGCCCCGGGGAGACGGACGCGTTTGGCAACAGCGAGGGC
AAAGAGCTGGTGGCCTCAGGTGAAAACAAAATAAAACAGGGTCTGTTACCTAGCTTGGAA
GATTTGCTGTTCTATACAATTGCTGAAGGACAAGAGAAAATACCTGTTCATAAATTTATT
ACAGCACTCAAATCTACAGGATTGCGAACGTCTGATCCCAGGTTGAAAGAGTGTATGGAT
ATGTTAAGATTAACTCTTCAAACAACATCAGATGGTGTCATGCTAGACAAAGATCTTTTT
AAAAAATGTGTTCAGAGCAACATTGTTTTGTTGACACAAGCATTTAGAAGAAAGTTTGTG
ATTCCTGACTTTATGTCTTTTACCTCACACATTGATGAGTTATATGAAAGTGCTAAAAAG
CAGTCTGGAGGAAAGGTTGCAGATTATATTCCTCAACTGGCCAAATTCAGTCCCGATTTG
TGGGGTGTGTCTGTTTGTACAGCAGATGGACAGAGGCATTCTACTGGAGATACCAAAGTT
CCCTTCTGTCTTCAGTCCTGTGTAAAACCTTTGAAATATGCCATTGCTGTTAATGATCTT
GGAACTGAATATGTGCATCGATATGTTGGAAAAGAGCCGAGTGGACTAAGATTCAACAAA
CTATTTTTGAATGAAGATGATAAACCACATAATCCTATGGTAAATGCTGGAGCAATTGTT
GTGACTTCACTAATAAAGCAAGGAGTAAATAATGCTGAAAAATTTGACTATGTCATGCAG
TTTTTGAATAAGATGGCTGGTAATGAATATGTTGGATTCAGTAATGCAACGTTTCAGTCT
GAAAGAGAAAGTGGAGATCGAAATTTTGCAATAGGATATTACTTAAAAGAAAAGAAGTGT
TTTCCAGAAGGCACAGACATGGTTGGTATATTAGACTTCTACTTCCAGCTGTGCTCCATT
GAAGTGACTTGTGAATCAGCCAGTGTGATGGCTGCGACACTGGCTAATGGTGGTTTCTGC
CCAATTACTGGTGAAAGAGTACTGAGCCCTGAAGCAGTTCGAAATACATTGAGTTTGATG
CATTCCTGTGGCATGTATGACTTCTCAGGGCAGTTTGCTTTCCATGTTGGTCTTCCTGCA
AAATCTGGAGTTGCTGGGGGCATTCTTTTAGTTGTCCCCAATGTTATGGGTATGATGTGC
TGGTCTCCTCCTCTGGATAAGATGGGCAACAGTGTTAAGGGAATTCACTTTTGTCACGAT
CTTGTTTCTCTGTGTAATTTCCATAACTATGATAATTTGAGACACTTTGCAAAAAAACTT
GATCCTCGAAGAGAAGGTGGTGATCAAAGGCATTCCTTTGGACCATTGGACTATGAAAGT
CTCCAACAAGAACTTGCTTTAAAAGAGACAGTATGGAAAAAAGTGTCACCTGAGTCAAAT
GAGGACATCTCTACAACTGTAGTATATAGAATGGAAAGTCTGGGAGAGAAAAGCTAA

# Metabolic_Enzyme_28_GenBank_ID_Gene:
AF158555

# Metabolic_Enzyme_28_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_28_Locus:
2q32-q34

# Metabolic_Enzyme_28_SNPs:
rs3732211; rs1168; rs1546646; rs3088307; rs1546647; rs10437; rs1546648; rs13035504; rs16833113; rs2883582; rs1921907; rs883844; rs1921914; rs867637; rs2203715; rs984610; rs11691127; rs1921915; rs4853454; rs1921912; rs3771316; rs4853531; rs6758866; rs6434429; rs6434430; rs2355570; rs4853530; rs11692579; rs1517356; rs4853528; rs6743496; rs932170; rs1921913; rs3771311; rs17815942; rs1517355; rs16833049; rs3771308; rs3771310; rs12998878; rs3771304; rs16833031; rs17748089; rs10931476; rs11683679; rs1607187; rs11693788; rs12987113; rs3771313; rs12185688; rs13001395; rs7564529; rs4597558; rs1517354; rs6713444; rs6721631; rs13384728; rs10497710; rs3732212; rs2355571; rs2883713; rs16833050; rs2108818; rs11894259; rs11681912; rs16833073; rs16833053; rs16833056; rs1033249; rs13000464; rs16833092; rs16833069; rs3087950; rs13414554; rs16833067; rs12992618; rs11674731; rs11677838; rs3771307; rs16833042; rs6712504; rs11688967; rs11889157; rs3771314; rs4853529; rs16833040; rs11675981; rs16833020; rs12467368; rs1921909; rs3755313; rs16833035; rs35890674; rs1801893; rs17853842; rs3199238; rs3207596; rs1136115; rs1058590; rs1136112; rs1136107; rs1136111; rs1058592; rs1801892; rs1058589; rs3207595; rs3199237; rs3207597; rs1136114; rs1058591; rs1136113; rs3836129; rs34962483; rs28930678; rs11268964; rs11272113; rs34913321; rs34693346; rs10645506; rs34009071; rs34646339; rs13024969; rs35753740; rs12620987; rs33957014; rs34322022; rs11386437; rs5837213; rs34719838; rs11306120; rs33998570; rs34470725; rs11547780; rs36064959; rs11547781; rs34687743; rs3217036; rs6751852; rs11886120; rs34219109; rs34101296; rs10198061; rs6713807; rs7586514; rs11368612; rs5837211; rs35376983; rs11299475; rs34298947; rs35621182; rs34999321; rs1045208; rs34287390; rs34660567; rs10529560; rs35016708; rs6729740; rs34844301; rs3771309; rs34841385; rs34809982; rs3821234; rs13399044; rs34359726; rs35122426; rs7602927; rs4511752; rs4853452; rs10532100; rs35048130; rs35360323; rs36013374; rs10623498; rs34798536; rs3215259; rs34801561; rs36074537; rs33972110; rs36025643; rs2292790; rs35915280; rs34900059; rs10590551; rs35272604; rs2355572; rs36008676; rs35542564; rs34419675; rs13414648; rs35034516; rs34717146; rs11363248; rs35910874; rs5837212; rs10716407; rs13391964; rs35968676; rs35712414; rs11377483; rs2178605; rs3771312; rs34752857; rs33958764; rs13012566; rs2292792; rs34312179; rs13017410; rs34466013; rs3039186; rs11370315; rs3036651; rs41270235; rs34914533; rs35453613; rs12990256; rs4853453; rs10221634; rs3771303; rs35957111; rs34053475; rs35745438; rs34321717; rs35868744; rs34901974; rs11547782; rs13414269; rs10665259; rs34793584; rs13000734; rs2292791; rs7558585; rs17816440; rs16833121; rs28362510; rs12997127; rs35314646; rs11305; rs11687659; rs11690599; rs11885168; rs11894425; rs11899865; rs12468579; rs12693589; rs12987796; rs13395505; rs1400657; rs16824035; rs16833123; rs16833126; rs17748980; rs1914407; rs1914408; rs2066793; rs2066803; rs2204859; rs35364817; rs3771300; rs4853526; rs4853533; rs6718902; rs6734110; rs7575823; rs9789700

# Metabolic_Enzyme_28_General_References:
11015561; 10048485; 10719215

# Metabolic_Enzyme_28_References:
Not Available

# Metabolic_Enzyme_29_ID:
5954

# Metabolic_Enzyme_29_Name:
Protein-glutamine gamma-glutamyltransferase 4

# Metabolic_Enzyme_29_Synonyms:
Transglutaminase-4; TGase-4; Prostate transglutaminase; TGP; TG(P; Prostate-specific transglutaminase; Fibrinoligase

# Metabolic_Enzyme_29_Gene_Name:
TGM4

# Metabolic_Enzyme_29_Protein_Sequence:
>Proteinglutamine gammaglutamyltransferase 4
MMDASKELQVLHIDFLNQDNAVSHHTWEFQTSSPVFRRGQVFHLRLVLNQPLQSYHQLKL
EFSTGPNPSIAKHTLVVLDPRTPSDHYNWQATLQNESGKEVTVAVTSSPNAILGKYQLNV
KTGNHILKSEENILYLLFNPWCKEDMVFMPDEDERKEYILNDTGCHYVGAARSIKCKPWN
FGQFEKNVLDCCISLLTESSLKPTDRRDPVLVCRAMCAMMSFEKGQGVLIGNWTGDYEGG
TAPYKWTGSAPILQQYYNTKQAVCFGQCWVFAGILTTVLRALGIPARSVTGFDSAHDTER
NLTVDTYVNENGEKITSMTHDSVWNFHVWTDAWMKRPDLPKGYDGWQAVDATPQERSQGV
FCCGPSPLTAIRKGDIFIVYDTRFVFSEVNGDRLIWLVKMVNGQEELHVISMETTSIGKN
ISTKAVGQDRRRDITYEYKYPEGSSEERQVMDHAFLLLSSEREHRRPVKENFLHMSVQSD
DVLLGNSVNFTVILKRKTAALQNVNILGSFELQLYTGKKMAKLCDLNKTSQIQGQVSEVT
LTLDSKTYINSLAILDDEPVIRGFIIAEIVESKEIMASEVFTSFQYPEFSIELPNTGRIG
QLLVCNCIFKNTLAIPLTDVKFSLESLGISSLQTSDHGTVQPGETIQSQIKCTPIKTGPK
KFIVKLSSKQVKEINAQKIVLITK

# Metabolic_Enzyme_29_Number_of_Residues:
684

# Metabolic_Enzyme_29_Molecular_Weight:
77146

# Metabolic_Enzyme_29_Theoretical_pI:
6.75

# Metabolic_Enzyme_29_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  peptide cross-linking
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_29_General_Function:
Not Available

# Metabolic_Enzyme_29_Specific_Function:
Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract

# Metabolic_Enzyme_29_Pathway:
Not Available

# Metabolic_Enzyme_29_Reaction:
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3

# Metabolic_Enzyme_29_Pfam_Domain_Function:
PF00927:Transglut_C;
PF01841:Transglut_core;
PF00868:Transglut_N

# Metabolic_Enzyme_29_Signals:
None

# Metabolic_Enzyme_29_Transmembrane_Regions:
None

# Metabolic_Enzyme_29_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_29_EC_Link:
EC 2.3.2.13

# Metabolic_Enzyme_29_GenBank_ID_Protein:
2766556

# Metabolic_Enzyme_29_SwissProt_ID:
TGM4_HUMAN (P49221)

# Metabolic_Enzyme_29_swissprot_Name:
Not Available

# Metabolic_Enzyme_29_Genecard_id:
TGM4

# Metabolic_Enzyme_29_Geneatlas_id:
TGM4

# Metabolic_Enzyme_29_hgnc_id:
HGNC:11780

# Metabolic_Enzyme_29_PDB_ID:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_29_Subcellular_Location:
Not Available

# Metabolic_Enzyme_29_Gene_Sequence:
>2055 bp
ATGATGGATGCATCAAAAGAGCTGCAAGTTCTCCACATTGACTTCTTGAATCAGGACAAC
GCCGTTTCTCACCACACATGGGAGTTCCAAACGAGCAGTCCTGTGTTCCGGCGAGGACAG
GTGTTTCACCTGCGGCTGGTGCTGAACCAGCCCCTACAATCCTACCACCAACTGAAACTG
GAATTCAGCACAGGGCCGAATCCTAGCATCGCCAAACACACCCTGGTGGTGCTCGACCCG
AGGACGCCCTCAGACCACTACAACTGGCAGGCAACCCTTCAAAATGAGTCTGGCAAAGAG
GTCACAGTGGCTGTCACCAGTTCCCCCAATGCCATCCTGGGCAAGTACCAACTAAACGTG
AAAACTGGAAACCACATCCTTAAGTCTGAAGAAAACATCCTATACCTTCTCTTCAACCCA
TGGTGTAAAGAGGACATGGTTTTCATGCCTGATGAGGACGAGCGCAAAGAGTACATCCTC
AATGACACGGGCTGCCATTACGTGGGGGCTGCCAGAAGTATCAAATGCAAACCCTGGAAC
TTTGGTCAGTTTGAGAAAAATGTCCTGGACTGCTGCATTTCCCTGCTGACTGAGAGCTCC
CTCAAGCCCACAGATAGGAGGGACCCCGTGCTGGTGTGCAGGGCCATGTGTGCTATGATG
AGCTTTGAGAAAGGCCAGGGCGTGCTCATTGGGAATTGGACTGGGGACTACGAAGGTGGC
ACAGCCCCATACAAGTGGACAGGCAGTGCCCCGATCCTGCAGCAGTACTACAACACGAAG
CAGGCTGTGTGCTTTGGCCAGTGCTGGGTGTTTGCTGGGATCCTGACTACAGTGCTGAGA
GCGTTGGGCATCCCAGCACGCAGTGTGACAGGCTTCGATTCAGCTCACGACACAGAAAGG
AACCTCACGGTGGACACCTATGTGAATGAGAATGGCGAGAAAATCACCAGTATGACCCAC
GACTCTGTCTGGAATTTCCATGTGTGGACGGATGCCTGGATGAAGCGACCGGATCTGCCC
AAGGGCTACGACGGCTGGCAGGCTGTGGACGCAACGCCGCAGGAGCGAAGCCAGGGTGTC
TTCTGCTGTGGGCCATCACCACTGACCGCCATCCGCAAAGGTGACATCTTTATTGTCTAT
GACACCAGATTCGTCTTCTCAGAAGTGAATGGTGACAGGCTCATCTGGTTGGTGAAGATG
GTGAATGGGCAGGAGGAGTTACACGTAATTTCAATGGAGACCACAAGCATCGGGAAAAAC
ATCAGCACCAAGGCAGTGGGCCAAGACAGGCGGAGAGATATCACCTATGAGTACAAGTAT
CCAGAAGGCTCCTCTGAGGAGAGGCAGGTCATGGATCATGCCTTCCTCCTTCTCAGTTCT
GAGAGGGAGCACAGACGACCTGTAAAAGAGAACTTTCTTCACATGTCGGTACAATCAGAT
GATGTGCTGCTGGGAAACTCTGTTAATTTCACCGTGATTCTTAAAAGGAAGACCGCTGCC
CTACAGAATGTCAACATCTTGGGCTCCTTTGAACTACAGTTGTACACTGGCAAGAAGATG
GCAAAACTGTGTGACCTCAATAAGACCTCGCAGATCCAAGGTCAAGTATCAGAAGTGACT
CTGACCTTGGACTCCAAGACCTACATCAACAGCCTGGCTATATTAGATGATGAGCCAGTT
ATCAGAGGTTTCATCATTGCGGAAATTGTGGAGTCTAAGGAAATCATGGCCTCTGAAGTA
TTCACGTCTTTCCAGTACCCTGAGTTCTCTATAGAGTTGCCTAACACAGGCAGAATTGGC
CAGCTACTTGTCTGCAATTGTATCTTCAAGAATACCCTGGCCATCCCTTTGACTGACGTC
AAGTTCTCTTTGGAAAGCCTGGGCATCTCCTCACTACAGACCTCTGACCATGGGACGGTG
CAGCCTGGTGAGACCATCCAATCCCAAATAAAATGCACCCCAATAAAAACTGGACCCAAG
AAATTTATCGTCAAGTTAAGTTCCAAACAAGTGAAAGAGATTAATGCTCAGAAGATTGTT
CTCATCACCAAGTAG

# Metabolic_Enzyme_29_GenBank_ID_Gene:
L34840

# Metabolic_Enzyme_29_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_29_Locus:
3p22-p21.33

# Metabolic_Enzyme_29_SNPs:
rs1995641; rs13326552; rs2271087; rs9818345; rs9876921; rs3749195; rs17077022; rs937838; rs1395388; rs1995640; rs34772357; rs34630572; rs34547377; rs1007; rs7642831; rs937837; rs1520082; rs1464296; rs4683005; rs1354767; rs13320377; rs4622937; rs6777798; rs6768893; rs6804037; rs1354768; rs6766025; rs6441872; rs1532898; rs937835; rs2242476; rs6784318; rs952662; rs4683007; rs3828354; rs4683001; rs6789626; rs2011446; rs12632450; rs4682756; rs9832678; rs9683370; rs9829341; rs6778676; rs1995639; rs937833; rs11916548; rs12634217; rs7340548; rs9823957; rs11130037; rs4683006; rs9683355; rs2089341; rs937836; rs4683009; rs4408902; rs4683010; rs4683000; rs7612574; rs13076123; rs12497045; rs4682759; rs9942026; rs7621750; rs9833819; rs2242475; rs3749194; rs4683004; rs9816639; rs1995638; rs1109412; rs2089340; rs877827; rs17076998; rs2036618; rs4683003; rs17077029; rs17077036; rs4683002; rs9823021; rs9828821; rs12632251; rs2135532; rs17077039; rs9811595; rs17850130; rs36081973; rs17850131; rs17850132; rs6650899; rs28633171; rs11707176; rs6441869; rs10620922; rs9834497; rs9822927; rs5848716; rs10580461; rs9942073; rs13072935; rs11719342; rs3082589; rs41289594; rs5848714; rs4682755; rs34004254; rs34569834; rs10531764; rs34199221; rs2372834; rs6765789; rs2372833; rs35425085; rs11369371; rs35781374; rs28666966; rs28705387; rs5848718; rs9871653; rs7373845; rs34936453; rs4683008; rs10614838; rs9836448; rs2372832; rs11387960; rs10622920; rs11708759; rs33981546; rs34205309; rs3804578; rs34193683; rs35054781; rs11928928; rs9798982; rs5848717; rs34801426; rs34860847; rs34268460; rs9811537; rs35980364; rs10429; rs1046827; rs12495512; rs12631990; rs1506659; rs1553606; rs17631716; rs1979946; rs2372849; rs2888422; rs34883405; rs3749193; rs6622; rs7621143; rs7622843; rs7644978; rs7645129; rs870950; rs937832; rs9826883; rs9848333; rs9857496; rs9863165

# Metabolic_Enzyme_29_General_References:
7916568; 8645175

# Metabolic_Enzyme_29_References:
Not Available

# Metabolic_Enzyme_30_ID:
5955

# Metabolic_Enzyme_30_Name:
Protein-glutamine gamma-glutamyltransferase K

# Metabolic_Enzyme_30_Synonyms:
Transglutaminase K; TGase K; TGK; TG(K; Transglutaminase-1; Epidermal TGase

# Metabolic_Enzyme_30_Gene_Name:
TGM1

# Metabolic_Enzyme_30_Protein_Sequence:
>Proteinglutamine gammaglutamyltransferase 
KMMDGPRSDVGRWGGNPLQPPTTPSPEPEPEPDGRSRRGGGRSFWARCCGCCSCRNAADD
DWGPEPSDSRGRGSSSGTRRPGSRGSDSRRPVSRGSGVNAAGDGTIREGMLVVNGVDLLS
SRSDQNRREHHTDEYEYDELIVRRGQPFHMLLLLSRTYESSDRITLELLIGNNPEVGKGT
HVIIPVGKGGSGGWKAQVVKASGQNLNLRVHTSPNAIIGKFQFTVRTQSDAGEFQLPFDP
RNEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWNYGQFDHGVLD
ACLYILDRRGMPYGGRGDPVNVSRVISAMVNSLDDNGVLIGNWSGDYSRGTNPSAWVGSV
EILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGLATRTVTNFNSAHDTDTSLTMDIYFDE
NMKPLEHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVDATPQETSSGIFCCGPCSVES
IKNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVEEKAIGTLIVTKAISSNMRED
ITYLYKHPEGSDAERKAVETAAAHGSKPNVYANRGSAEDVAMQVEAQDAVMGQDLMVSVM
LINHSSSRRTVKLHLYLSVTFYTGVSGTIFKETKKEVELAPGASDRVTMPVAYKEYRPHL
VDQGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQECEVQIVFKNPLPV
TLTNVVFRLEGSGLQRPKILNVGDIGGNETVTLRQSFVPVRPGPRQLIASLDSPQLSQVH
GVIQVDVAPAPGDGGFFSDAGGDSHLGETIPMASRGGA

# Metabolic_Enzyme_30_Number_of_Residues:
817

# Metabolic_Enzyme_30_Molecular_Weight:
89788

# Metabolic_Enzyme_30_Theoretical_pI:
5.92

# Metabolic_Enzyme_30_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  peptide cross-linking
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_30_General_Function:
Not Available

# Metabolic_Enzyme_30_Specific_Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum

# Metabolic_Enzyme_30_Pathway:
Not Available

# Metabolic_Enzyme_30_Reaction:
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3

# Metabolic_Enzyme_30_Pfam_Domain_Function:
PF00927:Transglut_C;
PF01841:Transglut_core;
PF00868:Transglut_N

# Metabolic_Enzyme_30_Signals:
None

# Metabolic_Enzyme_30_Transmembrane_Regions:
None

# Metabolic_Enzyme_30_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_30_EC_Link:
EC 2.3.2.13

# Metabolic_Enzyme_30_GenBank_ID_Protein:
1256959

# Metabolic_Enzyme_30_SwissProt_ID:
TGM1_HUMAN (P22735)

# Metabolic_Enzyme_30_swissprot_Name:
Not Available

# Metabolic_Enzyme_30_Genecard_id:
TGM1

# Metabolic_Enzyme_30_Geneatlas_id:
TGM1

# Metabolic_Enzyme_30_hgnc_id:
HGNC:11777

# Metabolic_Enzyme_30_PDB_ID:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_30_Subcellular_Location:
Membrane; lipid-anchor

# Metabolic_Enzyme_30_Gene_Sequence:
>2454 bp
ATGATGGATGGGCCACGTTCCGATGTGGGCCGTTGGGGTGGCAACCCCTTGCAGCCCCCT
ACCACGCCATCTCCAGAGCCAGAGCCAGAGCCAGACGGACGCTCTCGCAGAGGAGGAGGC
CGTTCCTTCTGGGCTCGCTGCTGTGGCTGCTGTTCATGCCGAAATGCGGCAGATGACGAC
TGGGGACCTGAACCCTCTGACTCCAGGGGTCGAGGGTCCAGCTCTGGCACTCGAAGACCT
GGCTCCCGGGGCTCAGACTCCCGCCGGCCTGTATCCCGGGGCAGCGGTGTCAATGCAGCT
GGAGATGGCACCATCCGAGAGGGCATGCTAGTAGTGAACGGTGTGGACTTGCTGAGCTCG
CGCTCGGACCAGAACCGCCGAGAGCACCACACAGACGAGTATGAGTACGACGAGCTGATA
GTGCGCCGCGGGCAGCCTTTCCATATGCTCCTCCTCCTGTCCCGGACCTATGAATCCTCT
GATCGCATCACCCTTGAGTTACTCATCGGAAACAACCCCGAGGTGGGCAAGGGCACGCAC
GTGATCATCCCAGTGGGCAAGGGGGGCAGTGGAGGCTGGAAAGCCCAGGTGGTCAAGGCC
AGTGGGCAGAATCTGAACCTGCGGGTCCACACTTCCCCCAACGCCATCATCGGCAAGTTT
CAGTTCACAGTCCGCACACAATCAGACGCTGGGGAGTTCCAGTTGCCCTTTGACCCCCGC
AATGAGATCTACATCCTCTTCAACCCCTGGTGCCCAGAGGACATTGTGTACGTGGACCAT
GAGGATTGGCGGCAGGAGTATGTTCTTAATGAGTCTGGGAGAATTTACTACGGGACCGAA
GCACAGATTGGTGAGCGGACCTGGAACTACGGCCAGTTTGACCACGGGGTGCTGGATGCC
TGCTTATACATCCTGGACCGGCGGGGGATGCCATATGGAGGCCGTGGAGACCCAGTCAAT
GTCTCCCGGGTCATCTCTGCCATGGTGAACTCCCTGGATGACAATGGAGTCCTGATTGGG
AACTGGTCTGGTGATTACTCCCGAGGCACCAACCCATCAGCGTGGGTGGGCAGCGTGGAG
ATCCTGCTTAGCTACCTACGCACGGGATATTCCGTCCCCTATGGCCAGTGCTGGGTCTTT
GCTGGCGTGACCACCACAGTGCTGCGCTGCCTGGGTCTGGCCACCCGTACTGTCACCAAC
TTCAACTCCGCCCACGACACAGACACATCCCTTACCATGGACATCTACTTCGACGAGAAC
ATGAAGCCCCTGGAGCACCTGAACCATGATTCTGTCTGGAACTTCCATGTGTGGAACGAC
TGCTGGATGAAGAGGCCGGATCTGCCCTCGGGCTTTGATGGGTGGCAGGTGGTGGATGCC
ACACCCCAAGAGACTAGCAGTGGCATCTTCTGCTGCGGCCCCTGCTCTGTGGAGTCCATC
AAGAATGGCCTGGTCTACATGAAGTACGACACGCCTTTCATTTTTGCTGAGGTGAATAGT
GACAAGGTGTACTGGCAGCGGCAGGATGATGGCAGCTTCAAGATTGTTTATGTGGAGGAG
AAGGCCATCGGCACACTCATTGTCACAAAGGCCATCAGCTCCAACATGCGGGAGGACATC
ACCTACCTCTATAAGCACCCAGAAGGCTCAGACGCAGAGCGGAAGGCAGTAGAGACAGCA
GCAGCCCACGGCAGCAAACCCAATGTGTATGCCAACCGGGGCTCAGCGGAGGATGTGGCC
ATGCAGGTGGAGGCACAGGACGCGGTGATGGGGCAGGATCTGATGGTCTCTGTGATGCTG
ATCAATCACAGCAGCAGCCGCCGCACAGTGAAACTGCACCTCTACCTCTCAGTCACTTTC
TATACTGGTGTCAGTGGTACCATCTTCAAGGAGACCAAGAAGGAAGTGGAGCTGGCACCA
GGGGCCTCGGACCGTGTGACCATGCCAGTGGCCTACAAGGAATACCGGCCCCATCTTGTG
GACCAGGGGGCCATGCTGCTCAATGTCTCAGGCCACGTCAAGGAGAGCGGGCAGGTGCTG
GCCAAGCAGCACACCTTCCGTCTGCGCACCCCAGACCTCTCCCTCACGTTACTGGGAGCA
GCAGTGGTTGGCCAGGAGTGTGAAGTACAGATTGTCTTCAAGAACCCCCTTCCCGTCACC
CTCACCAATGTCGTCTTCCGGCTCGAAGGCTCTGGGTTACAGAGGCCCAAGATCCTCAAC
GTTGGGGACATTGGAGGCAATGAAACAGTGACACTGCGCCAGTCGTTTGTGCCTGTGCGA
CCAGGCCCCCGCCAGCTCATTGCCAGCTTGGACAGCCCACAGCTCTCCCAGGTGCACGGT
GTCATCCAGGTGGATGTGGCCCCAGCCCCTGGGGATGGGGGCTTCTTCTCAGACGCTGGA
GGTGACAGTCACTTAGGAGAGACCATCCCTATGGCATCTCGAGGTGGAGCTTAG

# Metabolic_Enzyme_30_GenBank_ID_Gene:
M98447

# Metabolic_Enzyme_30_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_30_Locus:
14q11.2

# Metabolic_Enzyme_30_SNPs:
rs2228337; rs35312232; rs35926651; rs2229464; rs2229462; rs17102410; rs35755034; rs41295336; rs1126432; rs2273302; rs2229463; rs17256811; rs2748513; rs2748531; rs7151201; rs2273303; rs1950494; rs2855098; rs8193032; rs35692401; rs8193033; rs2277486; rs34597632; rs3783442; rs17794788; rs2855094; rs17102378; rs17102396; rs17102408; rs41293786; rs2256989; rs36114057; rs41293818; rs41293828; rs8193034; rs41293792; rs41295332; rs41293834; rs34955494; rs3742506; rs2277485; rs2748516; rs41293944; rs41293838; rs41293814; rs34987032; rs4982880; rs41293956; rs41293788; rs4982881; rs2748525; rs4982882; rs41293836; rs7158744; rs941505; rs11625433; rs2273301; rs3814814; rs41295322; rs41294732; rs41294728; rs3814813; rs41294730; rs941504; rs7147300; rs41293794; rs2855111; rs2748529; rs41295338; rs2855009; rs2855105; rs2855110; rs2855109; rs2748528; rs2228336; rs41295340; rs41295444; rs2855005; rs8193031; rs2855112; rs2854998; rs2144486; rs2855007; rs2748512; rs8003142; rs2748536; rs8193035; rs2748514; rs41294726; rs2855107; rs34774258; rs2855092; rs41293784; rs2748517; rs41293840; rs2855012; rs2855011; rs41293796; rs41293826; rs2748532; rs41293948; rs2854996; rs2855101; rs7147837; rs41293810; rs41293950; rs2855097; rs8012492; rs3832938; rs2748520; rs41295330; rs41293798; rs35902378; rs2748527; rs2748530; rs2855106; rs2855001; rs2748533; rs2855010; rs41295342; rs2855093; rs34038141; rs2854995; rs2748523; rs41293952; rs35813315; rs2855102; rs41293806; rs41293808; rs41293822; rs12435893; rs41293780; rs35367573; rs2855099; rs41293816; rs2748534; rs2855002; rs41293830; rs41295334; rs41293782; rs2748519; rs2748535; rs41293842; rs41293800; rs2748524; rs3216749; rs2855103; rs2855015; rs2855095; rs41293790; rs2855004; rs2855008; rs2748518; rs35101954; rs2748515; rs2748521; rs2854994; rs1950493; rs41293954; rs2855108; rs2855003; rs41293802; rs2748526; rs41293832; rs41293812; rs2855013; rs34794036; rs4456423; rs11432317; rs41293804; rs2855014; rs2855096; rs2854997; rs2855113; rs41293824; rs2855104; rs2855091; rs2854993; rs35504574; rs2748522; rs41293820; rs41293946; rs3841476; rs34714373; rs41295328; rs2075530; rs41295324; rs8004517; rs2332229; rs33931317; rs41295326; rs34282188; rs34491912; rs10141326; rs10148135; rs1050589; rs11626191; rs11844422; rs12883582; rs12886219; rs12897704; rs14193; rs17102311; rs17102313; rs2180196; rs2281473; rs2295311; rs2295313; rs2295314; rs2295315; rs2877612; rs34113897; rs34861984; rs34973999; rs3818161; rs3825585; rs4982877; rs6573652; rs7145550; rs729421; rs766601; rs766602; rs941503

# Metabolic_Enzyme_30_General_References:
1346394; 1670769; 1979171; 1673840; 1350092; 1381356; 1351505; 7824952; 7773290; 9326318; 11251583

# Metabolic_Enzyme_30_References:
Not Available

# Metabolic_Enzyme_31_ID:
5956

# Metabolic_Enzyme_31_Name:
Histidine ammonia-lyase

# Metabolic_Enzyme_31_Synonyms:
Histidase

# Metabolic_Enzyme_31_Gene_Name:
HAL

# Metabolic_Enzyme_31_Protein_Sequence:
>Histidine ammonialyase
MPRYTVHVRGEWLAVPCQDAQLTVGWLGREAVRRYIKNKPDNGGFTSVDDAHFLVRRCKG
LGLLDNEDRLEVALENNEFVEVVIEGDAMSPDFIPSQPEGVYLYSKYREPEKYIELDGDR
LTTEDLVNLGKGRYKIKLTPTAEKRVQKSREVIDSIIKEKTVVYGITTGFGKFARTVIPI
NKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIEMFNAS
CLPYVPEKGTVGASGDLAPLSHLALGLVGEGKMWSPKSGWADAKYVLEAHGLKPVILKPK
EGLALINGTQMITSLGCEAVERASAIARQADIVAALTLEVLKGTTKAFDTDIHALRPHRG
QIEVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKNIITT
ELNSATDNPMVFANRGETVSGGNFHGEYPAKALDYLAIGIHELAAISERRIERLCNPSLS
ELPAFLVAEGGLNSGFMIAHCTAAALVSENKALCHPSSVDSLSTSAATEDHVSMGGWAAR
KALRVIEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDI
EAAHRLLLEQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLQFLHKKSTKIPESEDL

# Metabolic_Enzyme_31_Number_of_Residues:
657

# Metabolic_Enzyme_31_Molecular_Weight:
72698

# Metabolic_Enzyme_31_Theoretical_pI:
6.95

# Metabolic_Enzyme_31_GO_Classification:
>>>
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  acid-ammonia (or amide) ligase activity
Function:  ammonia ligase activity
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-nitrogen lyase activity
Function:  ammonia-lyase activity
Function:  histidine ammonia-lyase activity
 ||
>>>
Process:  biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  histidine family amino acid metabolism
Process:  histidine metabolism
Process:  histidine catabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_31_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_31_Specific_Function:
L-histidine = urocanate + NH(3)

# Metabolic_Enzyme_31_Pathway:
map00340  Histidine metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_31_Reaction:
L-histidine = urocanate + NH3

# Metabolic_Enzyme_31_Pfam_Domain_Function:
PF00221:PAL

# Metabolic_Enzyme_31_Signals:
None

# Metabolic_Enzyme_31_Transmembrane_Regions:
None

# Metabolic_Enzyme_31_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_31_EC_Link:
EC 4.3.1.3

# Metabolic_Enzyme_31_GenBank_ID_Protein:
451210

# Metabolic_Enzyme_31_SwissProt_ID:
HUTH_HUMAN (P42357)

# Metabolic_Enzyme_31_swissprot_Name:
Not Available

# Metabolic_Enzyme_31_Genecard_id:
HAL

# Metabolic_Enzyme_31_Geneatlas_id:
HAL

# Metabolic_Enzyme_31_hgnc_id:
HGNC:4806

# Metabolic_Enzyme_31_PDB_ID:
Not Available

# Metabolic_Enzyme_31_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_31_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_31_Subcellular_Location:
Not Available

# Metabolic_Enzyme_31_Gene_Sequence:
>1974 bp
ATGCCCAGATACACGGTGCACGTACGTGGGGAATGGCTGGCAGTGCCCTGCCAGGACGCG
CAGCTCACTGTGGGCTGGCTGGGCCGGGAGGCCGTGAGGCGCTATATCAAGAATAAGCCC
GACAATGGTGGCTTCACCTCCGTGGATGACGCGCACTTCCTTGTGCGCCGGTGCAAGGGC
CTGGGCCTGCTGGACAACGAGGACCGGCTCGAGGTGGCCCTAGAGAACAACGAGTTCGTG
GAAGTGGTTATAGAGGGTGATGCCATGTCTCCTGACTTCATTCCATCTCAACCAGAAGGA
GTTTATCTATACAGCAAGTACCGGGAGCCTGAAAAGTACATCGAGTTAGATGGAGACCGT
CTGACCACGGAGGATCTGGTCAACTTGGGAAAGGGACGCTACAAAATAAAGCTCACCCCA
ACAGCTGAGAAGAGGGTGCAGAAATCCAGGGAGGTCATAGATAGCATCATAAAAGAGAAA
ACAGTTGTTTACGGTATTACTACAGGTTTTGGGAAATTTGCCAGAACTGTAATTCCTATC
AATAAGCTACAGGAGCTTCAGGTCAACTTAGTACGCTCACATTCTTCAGGTGTTGGGAAA
CCACTAAGTCCTGAGAGGTGTCGGATGCTCTTGGCTTTAAGGATCAATGTCTTAGCCAAA
GGATACAGTGGCATTTCCCTGGAGACCCTCAAACAAGTCATAGAAATGTTTAATGCCTCC
TGCCTGCCCTATGTCCCAGAGAAAGGAACCGTTGGTGCCAGTGGAGACCTTGCCCCACTC
TCTCATCTTGCTCTTGGGCTAGTTGGAGAAGGGAAGATGTGGTCTCCGAAGAGTGGCTGG
GCTGATGCTAAATACGTGCTAGAAGCCCATGGATTGAAACCAGTTATTTTAAAACCAAAA
GAGGGCCTGGCACTCATCAATGGGACGCAGATGATCACATCCCTGGGCTGTGAAGCTGTA
GAGCGAGCCAGTGCTATTGCACGGCAGGCTGACATTGTGGCAGCCCTGACCCTTGAGGTG
CTGAAGGGCACCACCAAAGCCTTTGACACTGACATTCATGCTCTTCGACCTCACCGTGGG
CAAATTGAAGTTGCTTTTCGGTTTCGGTCACTCTTGGACTCAGATCACCACCCATCAGAA
ATAGCAGAGAGTCACAGGTTCTGTGATCGCGTCCAGGATGCATACACCTTGCGCTGCTGT
CCACAGGTCCATGGTGTGGTGAATGATACAATAGCATTTGTGAAGAACATCATTACCACA
GAACTGAACAGCGCAACAGATAATCCTATGGTCTTTGCCAATAGGGGAGAGACAGTTTCT
GGAGGAAACTTCCATGGTGAATACCCAGCCAAAGCCCTAGACTACTTGGCCATTGGCATC
CATGAACTTGCTGCAATCAGTGAGAGAAGAATCGAGCGGCTCTGCAATCCCTCCCTCAGT
GAGCTGCCTGCCTTCCTGGTGGCTGAAGGTGGTCTGAACTCTGGGTTCATGATAGCTCAC
TGCACGGCAGCAGCCCTTGTTTCTGAGAACAAGGCTCTGTGCCATCCCTCGTCTGTTGAC
TCCCTCTCCACCAGCGCAGCCACGGAGGACCACGTCTCCATGGGAGGATGGGCAGCAAGG
AAAGCCCTCAGGGTCATCGAGCATGTGGAGCAAGTGCTGGCCATCGAGCTCCTTGCAGCC
TGCCAGGGCATAGAGTTTCTACGTCCCCTGAAAACAACCACTCCGCTGGAGAAGGTCTAT
GACCTGGTGCGCTCTGTTGTAAGGCCCTGGATAAAAGATCGCTTCATGGCCCCGGACATC
GAGGCAGCCCACAGGCTGCTCCTGGAGCAGAAGGTTTGGGAAGTAGCTGCTCCATACATT
GAAAAATACAGAATGGAGCATATTCCAGAATCAAGACCTCTTTCTCCAACAGCCTTTTCA
CTGCAATTTCTGCACAAGAAATCCACCAAAATCCCGGAGTCTGAGGACCTTTAA

# Metabolic_Enzyme_31_GenBank_ID_Gene:
D16626

# Metabolic_Enzyme_31_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_31_Locus:
12q22-q24.1

# Metabolic_Enzyme_31_SNPs:
rs7297245; rs17024973; rs2302628; rs11108364; rs36014288; rs2230885; rs11108369; rs2268520; rs2302629; rs2268518; rs10859996; rs11108366; rs2072511; rs2268517; rs3764038; rs11108368; rs2300560; rs3819817; rs10745747; rs2241136; rs3213737; rs10492227; rs10859995; rs7308827; rs17024981; rs17024935; rs7310419; rs12301817; rs2268519; rs2270318; rs17676826; rs10492228; rs10859997; rs17024956; rs7316786; rs11108356; rs12298414; rs721199; rs11108365; rs4762264; rs10745746; rs10777763; rs12318681; rs11108360; rs17024962; rs2068662; rs17024986; rs6538696; rs7133811; rs7966537; rs17676451; rs4762263; rs17024995; rs12427251; rs12319274; rs4762262; rs7308844; rs7137420; rs7136523; rs12307364; rs17024937; rs11108361; rs11108359; rs17677007; rs3741815; rs17733203; rs10859998; rs2241137; rs10777764; rs7308555; rs7136852; rs2070614; rs1059845; rs1059844; rs7134860; rs7970524; rs7134975; rs10859999; rs3829305; rs11835389; rs7956014; rs10777762; rs11108371; rs11108370; rs7306086; rs34457757; rs35643296; rs34268157; rs34541335; rs7304917; rs4418880; rs34738482; rs11108363; rs10708992; rs12814960; rs2287056; rs6538693; rs34148511; rs35249157; rs6538694; rs4451792; rs4595631; rs4762659; rs34975193; rs34466661; rs35532808; rs2270317; rs12810515; rs12809145; rs2287055; rs11108358; rs12298212; rs35351448; rs1108405; rs6538695; rs4995764; rs7137747; rs11108362; rs3214368; rs35963926; rs11108357; rs11108367; rs35777937; rs3764037; rs12297099; rs34515139; rs11454735; rs2287057; rs36054506; rs4995766; rs35144639; rs35152917; rs12810520; rs35559744; rs4995765; rs12822785; rs12809482; rs12297102; rs12309712; rs12298680; rs4325387; rs10537373; rs7975900; rs34539324; rs12310543; rs12824794; rs3812807; rs12231580; rs12826052; rs12826051; rs34149011; rs12231566; rs12826042; rs12826043; rs12231565; rs7976204; rs12826048; rs12826049; rs34600440; rs1025606; rs1025607; rs1025608; rs10507068; rs10507069; rs1050970; rs10777757; rs11108355; rs11108372; rs11108373; rs11613777; rs11614411; rs11826; rs11837995; rs12302993; rs12322336; rs12581429; rs17024904; rs17024908; rs17025016; rs17025023; rs17025026; rs17025028; rs17677343; rs1803916; rs2540499; rs2540500; rs4762258; rs4762657; rs4762658; rs5020450; rs7486464; rs7963056; rs7975895; rs7976105; rs7976535

# Metabolic_Enzyme_31_General_References:
7916645; 8530107

# Metabolic_Enzyme_31_References:
Not Available

# Metabolic_Enzyme_32_ID:
5631

# Metabolic_Enzyme_32_Name:
Retina-specific copper amine oxidase precursor

# Metabolic_Enzyme_32_Synonyms:
RAO; Amine oxidase [copper-containing]

# Metabolic_Enzyme_32_Gene_Name:
AOC2

# Metabolic_Enzyme_32_Protein_Sequence:
>Retinaspecific copper amine oxidase precursor
MHLKIVLAFLALSLITIFALAYVLLTSPGGSSQPPHCPSVSHRAQPWPHPGQSQLFADLS
REELTAVMRFLTQRLGPGLVDAAQAQPSDNCIFSVELQLPPKAAALAHLDRGSPPPAREA
LAIVLFGGQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLRAEFTQMWRHLK
EVELPKAPIFLSSTFNYNGSTLAAVHATPRGLRSGDRATWMALYHNISGVGLFLHPVGLE
LLLDHRALDPAHWTVQQVFYLGHYYADLGQLEREFKSGRLEVVRVPLPPPNGASSLRSRN
SPGPLPPLQFSPQGSQYSVQGNLVVSSLWSFTFGHGVFSGLRIFDVRFQGERIAYEVSVQ
ECVSIYGADSPKTMLTRYLDSSFGLGRNSRGLVRGVDCPYQATMVDIHILVGKGAVQLLP
GAVCVFEEAQGLPLRRHHNYLQNHFYGGLASSALVVRSVSSVGNYDYIWDFVLYPNGALE
GRVHATGYINTAFLKGGEEGLLFGNRVGERVLGTVHTHAFHFKLDLDVAGLKNWVVAEDV
VFKPVAAPWNPEHWLQRPQLTRQVLGKEDLTAFSLGSPLPRYLYLASNQTNAWGHQRGYR
IQIHSPLGIHIPLESDMERALSWGRYQLVVTQRKEEESQSSSIYHQNDIWTPTVTFADFI
NNETLLGEDLVAWVTASFLHIPHAEDIPNTVTLGNRVGFLLRPYNFFDEDPSIFSPGSVY
FEKGQDAGLCSINPVACLPDLAACVPDLPPFSYHGF

# Metabolic_Enzyme_32_Number_of_Residues:
756

# Metabolic_Enzyme_32_Molecular_Weight:
83674

# Metabolic_Enzyme_32_Theoretical_pI:
7.03

# Metabolic_Enzyme_32_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_32_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_32_Specific_Function:
May be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine

# Metabolic_Enzyme_32_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_32_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_32_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_32_Signals:
1-32

# Metabolic_Enzyme_32_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_32_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_32_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_32_GenBank_ID_Protein:
1906806

# Metabolic_Enzyme_32_SwissProt_ID:
AOC2_HUMAN (O75106)

# Metabolic_Enzyme_32_swissprot_Name:
Not Available

# Metabolic_Enzyme_32_Genecard_id:
AOC2

# Metabolic_Enzyme_32_Geneatlas_id:
AOC2

# Metabolic_Enzyme_32_hgnc_id:
HGNC:549

# Metabolic_Enzyme_32_PDB_ID:
Not Available

# Metabolic_Enzyme_32_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_32_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_32_Subcellular_Location:
Membrane

# Metabolic_Enzyme_32_Gene_Sequence:
>2190 bp
ATGCATCTCAAGATAGTCCTGGCGTTCCTGGCACTGTCCCTCATTACCATCTTTGCCCTG
GCCTATGTTTTGCTGACCAGCCCAGGTGGTTCCAGCCAGCCTCCCCACTGCCCCTCTGTA
TCCCATAGGGCCCAGCCCTGGCCACACCCTGGCCAGAGCCAGCTGTTTGCAGACCTGAGC
CGAGAGGAGTTGACAGCTGTGATGCGCTTTCTGACCCAGCGGCTGGGGCCAGGGCTGGTG
GACGCAGCCCAGGCTCAGCCCTCGGACAACTGCATCTTCTCAGTGGAGCTGCAGCTGCCC
CCCAAGGCTGCAGCCCTGGCCCACCTGGACAGGGGGAGCCCCCCACCTGCCCGGGAGGCA
CTGGCCATCGTCCTCTTTGGTGGACAACCCCAACCCAATGTGAGTGAGCTGGTGGTGGGG
CCGCTGCCTCACCCCTCGTACATGCGGGATGTGACTGTGGAGCGTCACGGCGGGCCCCTG
CCCTATCACCGTCGCCCGGTGCTGAGAGCTGAGTTTACACAGATGTGGAGGCATCTGAAA
GATGTGGAGCTACCCAAGGCACCCATCTTCCTGTCGTCCACCTTCAACTACAATGGCTCT
ACCCTGGCAGCTGTGCATGCCACCCCTCGGGGCTTGCGCTCAAGGGAACGAACTACCTGG
ATTGGCCTCTACCATAACATCTCAGGGGTTGGTCTTTTCCTTCACCCCGTGGGGCTGGAG
CTACTACTGGACCACAGGGCCCTGGACCCTGCCCACTGGACTGTCCAGCAGGTCTTCTAC
CTTGGGCACTACTATGCAGACTTGGGCCAGTTGGAACGGGAGTTTAAGTCTGGCCGGTTG
GAAGTGGTTAGAGTCCCTCTACCTCCACCAAATGGAGCTTCATCCCTGAGGTCTCGGAAC
TCTCCAGGTCCTCTTCCCCCTCTTCAGTTCTCGCCCCAGGGTTCCCAGTACAGTGTGCAA
GGAAACCTGGTGGTATCCTCCCTCTGGTCATTTACCTTTGGCCATGGGGTGTTCAGCGGC
CTGAGGATTTTTGATGTTCGGTTCCAGGGTGAGCGAATAGCCTATGAAGTCAGTGTCCAG
GAGTGTGTATCTATCTATGGTGCCGATTCACCCAAGACGATGCTGACTCGCTATTTGGAT
AGCAGCTTTGGACTCGGCCGTAACAGCCGAGGCTTGGTGCGGGGAGTGGACTGCCCCTAT
CAAGCCACGATGGTGGACATCCATATATTAGTGGGCAAAGGGGCAGTCCAGCTGCTTCCA
GGGGCTGTGTGTGTATTTGAGGAAGCCCAGGGACTGCCCCTTCGAAGGCACCACAATTAC
CTTCAAAATCATTTCTATGGTGGTTTGGCCAGCTCAGCCCTTGTGGTCAGGTCTGTGTCA
TCTGTGGGCAACTATGACTACATTTGGGACTTTGTGTTGTACCCAAATGGGGCACTTGAA
GGGCGGGTCCATGCCACGGGTTATATCAACACAGCTTTCCTGAAAGGGGGAGAGGAGGGC
CTCCTCTTTGGGAACCGTGTGGGGGAAAGAGTGCTGGGAACGGTGCACACACATGCCTTC
CACTTCAAGCTGGACCTGGATGTGGCAGGGCTGAAAAACTGGGTGGTAGCTGAAGACGTG
GTGTTTAAACCTGTGGCTGCCCCCTGGAACCCGGAGCACTGGCTACAGCGCCCACAGCTG
ACTCGGCAGGTCCTGGGAAAGGAGGACCTGACAGCTTTTTCCTTGGGAAGCCCCCTACCC
CGCTACCTCTACCTGGCTAGCAACCAGACTAATGCGTGGGGTCACCAGCGCGGATACCAG
CTTGTGGTGACCCAGAGAAAGGAGGAGGAGTCACAGAGCAGTAGCATCTATCACCAGAAT
GACATCTGGACACCCACAGTTACCTTTGCTGACTTCATCAACAATGAAACCCTCTTAGGA
GAGGATCTGGTGGCTTGGGTCACAGCCAGCTTCCTGCACATTCCCCATGCCGAGGACATC
CCAAACACAGTGACTCTGGGGAACAGAGTTGGCTTCTTGCTCCGACCCTATAACTTCTTT
GATGAGGACCCCTCCATCTTCTCCCCTGGCAGTGTGTACTTTGAGAAGGGCCAGGATGCT
GGGCTCTGCAGCATCAATCCTGTGGCCTGCCTCCCCGACCTGGCAGCCTGTGTCCCGGAC
TTACCCCCTTTCTCTTACCACGGCTTCTAG

# Metabolic_Enzyme_32_GenBank_ID_Gene:
D88213

# Metabolic_Enzyme_32_Chromosome_Location:
Not Available

# Metabolic_Enzyme_32_Locus:
Not Available

# Metabolic_Enzyme_32_SNPs:
Not Available

# Metabolic_Enzyme_32_General_References:
9119395; 9722954

# Metabolic_Enzyme_32_References:
Not Available

# Metabolic_Enzyme_33_ID:
5871

# Metabolic_Enzyme_33_Name:
AMP deaminase 2

# Metabolic_Enzyme_33_Synonyms:
AMP deaminase isoform L

# Metabolic_Enzyme_33_Gene_Name:
AMPD2

# Metabolic_Enzyme_33_Protein_Sequence:
>AMP deaminase 2
MRNRGQGLFRLRSRCFLHQSLPLGAGRRKGLDVAEPGPSRCRSDSPAVAAVVPAMASYPS
GSGKPKAKYPFKKRASLQASTAAPEARGGLGAPPLQSARSLPGPAPCLKHFPLDLRTSMD
GKCKEIAEELFTRSLAESELRSAPYEFPEESPIEQLEERRQRLERQISQDVKLEPDILLR
AKQDFLKTDSDSDLQLYKEQGEGQGDRSLRERDVLEREFQRVTISGEEKCGVPFTDLLDA
AKSVVRALFIREKYMALSLQSFCPTTRRYLQQLAEKPLETRTYEQGPDTPVSADAPVHPP
ALEQHPYEHCEPSTMPGDLGLGLRMVRGVVHVYTRREPDEHCSEVELPYPDLQEFVADVN
VLMALIINGPIKSFCYRRLQYLSSKFQMHVLLNEMKELAAQKKVPHRDFYNIRKVDTHIH
ASSCMNQKHLLRFIKRAMKRHLEEIVHVEQGREQTLREVFESMNLTAYDLSVDTLDVHAD
RNTFHRFDKFNAKYNPIGESVLREIFIKTDNRVSGKYFAHIIKEVMSDLEESKYQNAELR
LSIYGRSRDEWDKLARWAVMHRVHSPNVRWLVQVPRLFDVYRTKGQLANFQEMLENIFLP
LFEATVHPASHPELHLFLEHVDGFDSVDDESKPENHVFNLESPLPEAWVEEDNPPYAYYL
YYTFANMAMLNHLRRQRGFHTFVLRPHCGEAGPIHHLVSAFMLAENISHGLLLRKAPVLQ
YLYYLAQIGIAMSPLSNNSLFLSYHRNPLPEYLSRGLMVSLSTDDPLQFHFTKEPLMEEY
SIATQVWKLSSCDMCELARNSVLMSGFSHKVKSHWLGPNYTKEGPEGNDIRRTNVPDIRV
GYRYETLCQELALITQAVQSEMLETIPEEAGITMSPGPQ

# Metabolic_Enzyme_33_Number_of_Residues:
879

# Metabolic_Enzyme_33_Molecular_Weight:
100689

# Metabolic_Enzyme_33_Theoretical_pI:
6.93

# Metabolic_Enzyme_33_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  AMP deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_33_General_Function:
Not Available

# Metabolic_Enzyme_33_Specific_Function:
AMP deaminase plays a critical role in energy metabolism

# Metabolic_Enzyme_33_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_33_Reaction:
AMP + H2O = IMP + ammonia

# Metabolic_Enzyme_33_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_33_Signals:
None

# Metabolic_Enzyme_33_Transmembrane_Regions:
None

# Metabolic_Enzyme_33_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_33_EC_Link:
EC 3.5.4.6

# Metabolic_Enzyme_33_GenBank_ID_Protein:
644509

# Metabolic_Enzyme_33_SwissProt_ID:
AMPD2_HUMAN (Q01433)

# Metabolic_Enzyme_33_swissprot_Name:
Not Available

# Metabolic_Enzyme_33_Genecard_id:
AMPD2

# Metabolic_Enzyme_33_Geneatlas_id:
AMPD2

# Metabolic_Enzyme_33_hgnc_id:
HGNC:469

# Metabolic_Enzyme_33_PDB_ID:
Not Available

# Metabolic_Enzyme_33_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_33_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_33_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_33_Gene_Sequence:
>2263 bp
CGCCGAGGAGCTGTTCACCCGCTCACTGGCTGAGAGCGAGCTCCGTAGTGCCCCGTATGA
GTTCCCCGAGGAGAGCCCCATTGAACAGCTGGAGGAGCGGCGGCAGCGGCTGGAGCGGCA
GATCAGCCAGGATGTCAAGCTGGAGCCAGACATCCTGCTTCGGGCCAAGCAAGATTTCCT
GAAGACGGACAGTGACTCGGACCTACAGCTCTACAAGGAACAGGGTGAGGGGCAGGGTGA
CCGGAGCCTGCGGGAGCGTGATGTGCTGGAACGGGAGTTTCAGCGGGTCACCATCTCTGG
GGAGGAGAAGTGTGGGGTGCCGTTCACAGACCTGCTGGATGCAGCCAAGAGTGTGGTGCG
GGCGCTCTTCATCCGGGAGAAGTACATGGCCCTGTCCCTGCAGAGCTTCTGCCCCACCAC
CCGCCGCTACCTGCAGCAGCTGGCTGAAAAGCCTCTGGAGACCCGGACCTATGAACAGGG
CCCCGACACCCCTGTGTCTGCTGATGCCCCGGTGCACCCCCCTGCGCTGGAGCAGCACCC
GTATGAGCACTGTGAGCCAAGCACCATGCCTGGGGACCTGGGCTTGGGTCTGCGCATGGT
GCGGGGTGTGGTGCACGTCTACACCCGCAGGGAACCCGACGAGCATTGCTCAGAGGTGGA
GCTGCCATACCCTGACCTGCAGGAATTTGTGGCTGACGTCAATGTGCTGATGGCCCTGAT
TATCAATGGCCCCATAAAGTCATTCTGCTACCGCCGGCTGCAGTACCTGAGCTCCAAGTT
CCAGATGCATGTGCTACTCAATGAGATGAAGGAGCTGGCCGCCCAGAAGAAAGTGCCACA
CCGAGATTTCTACAACATCCGCAAGGTGGACACCCACATCCATGCCTCGTCCTGCATGAA
CCAGAAGCATCTGCTGCGCTTCATCAAGCGGGCAATGAAGCGGCACCTGGAGGAGATCGT
GCACGTGGAGCAGGGCCGTGAACAGACGCTGCGGGAGGTCTTTGAGAGCATGAATCTCAC
GGCCTACGACCTGAGTGTGGACACGCTGGATGTGCATGCGGACAGGAACACTTTCCATCG
CTTTGACAAGTTTAATGCCAAATACAACCCTATTGGGGAGTCCGTCCTCCGAGAGATCTT
CATCAAGACGGACAACAGGGTATCTGGGAAGTACTTTGCTCACATCATCAAGGAGGTGAT
GTCAGACCTGGAGGAGAGCAAATACCAGAATGCAGAGCTGCGGCTCTCCATTTACGGGCG
CTCGAGGGATGAGTGGGACAAGCTGGCGCGCTGGGCCGTCATGCACCGCGTGCACTCCCC
CAACGTGCGCTGGCTGGTGCAGGTGCCCCGCCTCTTTGATGTGTACCGTACCAAGGGCCA
GCTGGCCAACTTCCAGGAGATGCTGGAGAACATCTTCCTGCCACTGTTCGAGGCCACTGT
GCACCCTGCCAGCCACCCGGAACTGCATCTCTTCTTAGAGCACGTGGATGGTTTTGACAG
CGTGGATGATGAGTCCAAGCCTGAAAACCATGTCTTCAACCTGGAGAGCCCCCTGCCTGA
GGCGTGGGTGGAGGAGGACAACCCACCCTATGCCTACTACCTGTACTACACCTTTGCCAA
CATGGCCATGTTGAACCACCTGCGCAGGCAGAGGGGCTTCCACACGTTTGTGCTGAGGCC
ACACTGTGGGGAGGCTGGGCCCATCCACCACCTGGTGTCAGCCTTCATGCTGGCTGAGAA
CATTTCCCACGGGCTCCTTCTGCGCAAGGCCCCCGTCCTGCAGTACCTGTACTACCTGGC
CCAGATCGGCATCGCCATGTCTCCGCTCAGCAACAACAGCCTCTTCCTCAGCTATCACCG
GAATCCGCTACCGGAGTACCTGTCCCGCGGCCTCATGGTCTCCCTGTCCACTGATGATCC
CTTGCAGTTCCACTTCACCAAGGAGCCGCTGATGGAGGAGTACAGCATCGCCACCCAGGT
GTGGAAGCTCAGCTCCTGCGATATGTGTGAGCTGGCCCGCAACAGCGTGCTCATGAGCGG
CTTCTCGCACAAGGTAAAGAGCCACTGGCTGGGACCCAACTATACCAAGGAAGGCCCTGA
GGGGAATGACATCCGCCGGACCAATGTGCCAGACATCCGCGTGGGCTACCGCTACGAGAC
CCTGTGCCAGGAGCTGGCGCTCATCACGCAGGCAGTCCAGAGTGAGATGCTGGAGACCAT
TCCAGAGGAGGCGGGTATCACCATGAGCCCAGGGCCTCAATGA

# Metabolic_Enzyme_33_GenBank_ID_Gene:
M91029

# Metabolic_Enzyme_33_Chromosome_Location:
Not Available

# Metabolic_Enzyme_33_Locus:
Not Available

# Metabolic_Enzyme_33_SNPs:
Not Available

# Metabolic_Enzyme_33_General_References:
1429593; 8526848; 8764830

# Metabolic_Enzyme_33_References:
Not Available

# Metabolic_Enzyme_34_ID:
5815

# Metabolic_Enzyme_34_Name:
Beta-ureidopropionase

# Metabolic_Enzyme_34_Synonyms:
Beta-alanine synthase; N- carbamoyl-beta-alanine amidohydrolase; BUP-1

# Metabolic_Enzyme_34_Gene_Name:
UPB1

# Metabolic_Enzyme_34_Protein_Sequence:
>Betaureidopropionase
MAGAEWKSLEECLEKHLPLPDLQEVKRVLYGKELRKLDLPREAFEAASREDFELQGYAFE
AAEEQLRRPR
IVHVGLVQNRIPLPANAPVAEQVSALHRRIKAIVEVAAMCGVNIICFQE
AWTMPFAFCTREKLPWTEFAE
SAEDGPTTRFCQKLAKNHDMVVVSPILERDSEHGDVLW
NTAVVISNSGAVLGKTRKNHIPRVGDFNESTY
YMEGNLGHPVFQTQFGRIAVNICYGRH
HPLNWLMYSINGAEIIFNPSATIGALSESLWPIEARNAAIANH
CFTCAINRVGTEHFPN
EFTSGDGKKAHQDFGYFYGSSYVAAPDSSRTPGLSRSRDGLLVAKLDLNLCQQV
NDVWN
FKMTGRYEMYARELAEAVKSNYSPTIVKE

# Metabolic_Enzyme_34_Number_of_Residues:
384

# Metabolic_Enzyme_34_Molecular_Weight:
43166

# Metabolic_Enzyme_34_Theoretical_pI:
6.51

# Metabolic_Enzyme_34_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  nitrogen compound metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_34_General_Function:
Not Available

# Metabolic_Enzyme_34_Specific_Function:
Converts N-carbamyl-beta-aminoisobutyric acid and N- carbamyl-beta-alanine to, respectively, beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide

# Metabolic_Enzyme_34_Pathway:
map00240  Pyrimidine metabolism;
 map00410  beta-Alanine metabolism;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_34_Reaction:
N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3

# Metabolic_Enzyme_34_Pfam_Domain_Function:
PF00795:CN_hydrolase

# Metabolic_Enzyme_34_Signals:
None

# Metabolic_Enzyme_34_Transmembrane_Regions:
None

# Metabolic_Enzyme_34_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_34_EC_Link:
EC 3.5.1.6

# Metabolic_Enzyme_34_GenBank_ID_Protein:
6288771

# Metabolic_Enzyme_34_SwissProt_ID:
BUP1_HUMAN (Q9UBR1)

# Metabolic_Enzyme_34_swissprot_Name:
Not Available

# Metabolic_Enzyme_34_Genecard_id:
UPB1

# Metabolic_Enzyme_34_Geneatlas_id:
UPB1

# Metabolic_Enzyme_34_hgnc_id:
HGNC:16297

# Metabolic_Enzyme_34_PDB_ID:
Not Available

# Metabolic_Enzyme_34_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_34_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_34_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_34_Gene_Sequence:
>1155 bp

ATGGCGGGCGCTGAGTGGAAGTCGCTGGAGGAATGCTTGGAGAAGCACCTGCCGCTCCC
CGACTTGCAGG
AAGTGAAGCGCGTTCTCTATGGCAAGGAACTCAGGAAGCTTGATCTGC
CCAGGGAAGCTTTCGAAGCTGC
CTCCAGAGAAGACTTTGAACTGCAGGGATATGCCTTT
GAAGCAGCGGAGGAGCAGCTGAGACGACCCCGC
ATTGTGCACGTGGGGCTGGTTCAGAA
CAGAATCCCCCTCCCCGCAAATGCCCCTGTGGCAGAACAGGTCT
CTGCCCTTCATAGAC
GCATAAAGGCTATCGTAGAGGTGGCTGCAATGTGTGGAGTCAACATCATCTGTTT
CCAG
GAAGCATGGACTATGCCCTTTGCCTTCTGTACGAGAGAGAAGCTTCCTTGGACAGAATTT
GCTGAG
TCAGCAGAGGATGGGCCCACCACCAGATTCTGTCAGAAGCTGGCGAAGAACCA
TGACATGGTGGTGGTGT
CTCCCATCCTGGAACGAGACAGCGAGCATGGGGATGTTTTGT
GGAATACAGCCGTGGTGATCTCCAATTC
CGGAGCAGTCCTGGGAAAGACCAGGAAAAAC
CACATCCCCAGAGTGGGTGATTTCAACGAGTCAACTTAC
TACATGGAGGGAAACCTGGG
CCACCCCGTGTTCCAGACGCAGTTCGGAAGGATCGCGGTGAACATTTGCT
ACGGGCGGC
ACCACCCCCTCAACTGGCTTATGTACAGCATCAACGGGGCTGAGATCATCTTCAACCCCT
C
GGCCACGATAGGAGCACTCAGCGAGTCCCTGTGGCCCATCGAGGCCAGAAACGCAGCC
ATTGCCAATCAC
TGCTTCACCTGCGCCATCAATCGAGTGGGCACCGAGCACTTCCCGAA
CGAGTTTACCTCGGGAGATGGAA
AGAAAGCTCACCAGGACTTTGGCTACTTTTATGGCT
CGAGCTATGTGGCAGCCCCTGACAGCAGCCGGAC
TCCTGGGCTGTCCCGTAGCCGGGAT
GGACTGCTAGTTGCTAAGCTCGACCTAAACCTCTGCCAGCAGGTG
AATGATGTCTGGAA
CTTCAAGATGACGGGCAGGTATGAGATGTACGCACGGGAGCTCGCCGAAGCTGTCA
AGT
CCAACTACAGCCCCACCATCGTGAAAGAGTAG

# Metabolic_Enzyme_34_GenBank_ID_Gene:
AF163312

# Metabolic_Enzyme_34_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_34_Locus:
22q11.2

# Metabolic_Enzyme_34_SNPs:
rs34110964; rs2232867; rs1314; rs2070474; rs2232866; rs140330; rs6004171; rs1892721; rs2232868; rs738814; rs1015011; rs140324; rs5760464; rs140338; rs6004175; rs5996713; rs762279; rs8142051; rs140335; rs3788372; rs12159862; rs3788369; rs140337; rs131455; rs2298384; rs5760455; rs131456; rs1015050; rs12628029; rs6004167; rs5760467; rs175766; rs5996712; rs140334; rs4414772; rs35270298; rs2298385; rs3788370; rs5751894; rs9612646; rs3788371; rs8141985; rs5751893; rs140331; rs8139394; rs11912222; rs5760466; rs7290860; rs5760459; rs11704820; rs16978612; rs140332; rs2232865; rs6004174; rs5751892; rs7289159; rs2070473; rs34035085; rs9620392; rs2232870; rs35916595; rs2070475; rs34595756; rs33939150; rs6004176; rs175767; rs9608293; rs13055831; rs5760465; rs5760457; rs34272823; rs34212925; rs11704528; rs140339; rs5760461; rs5751891; rs9620394; rs34817009; rs35770800; rs5760458; rs5844593; rs9624489; rs131454; rs10428056; rs10427702; rs6004172; rs5760460; rs7290073; rs140326; rs12170801; rs41446544; rs11306738; rs8139687; rs35821245; rs140329; rs11912437; rs11704936; rs28588566; rs9612641; rs12159402; rs9624487; rs5751890; rs5996709; rs28793636; rs35606558; rs34346301; rs5760463; rs12168497; rs35350082; rs6004168; rs140327; rs5996711; rs34804666; rs12166299; rs140325; rs13056366; rs12170842; rs140328; rs131452; rs6004173; rs8137394; rs9624485; rs9624488; rs34688005; rs9624486; rs9612637; rs12159199; rs9608291; rs140333; rs10427760; rs5996710; rs12169955; rs2232864; rs6004169; rs3765615; rs11350644; rs140336; rs3032747; rs34577100; rs13056367; rs9624484; rs6004170; rs2232869; rs9612640; rs28461476; rs7289603; rs5760462; rs131453; rs4049935; rs34276962; rs5760456; rs11913979; rs9612643; rs34916208; rs34067128; rs41302573; rs2232863; rs2232862; rs2232858; rs2232860; rs5751889; rs7289016; rs2232861; rs2232859; rs2232857; rs11090327; rs131460; rs140342; rs1543757; rs17004940; rs4346492; rs4558681; rs4820592; rs4822501; rs4822502; rs5760449; rs5760450; rs5760451; rs5760452; rs5760469; rs5996707; rs5996715; rs9612648

# Metabolic_Enzyme_34_General_References:
10542323; 11508704

# Metabolic_Enzyme_34_References:
Not Available

# Metabolic_Enzyme_35_ID:
5957

# Metabolic_Enzyme_35_Name:
Protein-arginine deiminase type-2

# Metabolic_Enzyme_35_Synonyms:
Protein-arginine deiminase type II; Peptidylarginine deiminase II; PAD-H19

# Metabolic_Enzyme_35_Gene_Name:
PADI2

# Metabolic_Enzyme_35_Protein_Sequence:
>Proteinarginine deiminase type2
MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWVEVVRDGEAEE
VATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIEISL
DVDADRDGVVEKNNPKKASWTWGPEGQGAILLVNCDRETPWLPKEDCRDEKVYSKEDLKD
MSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGRRKLYHVVK
YTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQDIPLTPIFTDTVIFRIAPWIMT
PNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEA
PHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVN
GKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVP
IPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQE
NLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGI
PKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKW
WHMVP

# Metabolic_Enzyme_35_Number_of_Residues:
665

# Metabolic_Enzyme_35_Molecular_Weight:
75565

# Metabolic_Enzyme_35_Theoretical_pI:
5.28

# Metabolic_Enzyme_35_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Function:  protein-arginine deiminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_35_General_Function:
Not Available

# Metabolic_Enzyme_35_Specific_Function:
Catalyzes the deimination of arginine residues of proteins

# Metabolic_Enzyme_35_Pathway:
Not Available

# Metabolic_Enzyme_35_Reaction:
protein L-arginine + H2O = protein L-citrulline + NH3

# Metabolic_Enzyme_35_Pfam_Domain_Function:
PF03068:PAD;
PF08527:PAD_M;
PF08526:PAD_N

# Metabolic_Enzyme_35_Signals:
None

# Metabolic_Enzyme_35_Transmembrane_Regions:
None

# Metabolic_Enzyme_35_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_35_EC_Link:
EC 3.5.3.15

# Metabolic_Enzyme_35_GenBank_ID_Protein:
5572747

# Metabolic_Enzyme_35_SwissProt_ID:
PADI2_HUMAN (Q9Y2J8)

# Metabolic_Enzyme_35_swissprot_Name:
Not Available

# Metabolic_Enzyme_35_Genecard_id:
PADI2

# Metabolic_Enzyme_35_Geneatlas_id:
PADI2

# Metabolic_Enzyme_35_hgnc_id:
HGNC:18341

# Metabolic_Enzyme_35_PDB_ID:
Not Available

# Metabolic_Enzyme_35_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_35_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_35_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_35_Gene_Sequence:
>1998 bp
ATGCTGCGCGAGCGGACCGTGCGGCTGCAGTACGGGAGCCGCGTGGAGGCGGTGTACGTG
CTGGGCACCTACCTCTGGACCGATGTCTACAGCGCGGCCCCAGCCGGGGCCCAAACCTTC
AGCCTGAAGCACTCGGAACACGTGTGGGTGGAGGTGGTGCGTGATGGGGAGGCTGAGGAG
GTGGCCACCAATGGCAAGCAGCGCTGGCTTCTCTCGCCCAGCACCACCCTGCGGGTCACC
ATGAGCCAGGCGAGCACCGAGGCCAGCAGTGACAAGGTCACCGTCAACTACTATGACGAG
GAAGGGAGCATTCCCATCGACCAGGCGGGGCTCTTCCTCACAGCCATTGAGATCTCCCTG
GATGTGGACGCAGACCGGGATGGTGTGGTGGAGAAGAACAACCCAAAGAAGGCATCCTGG
ACCTGGGGCCCCGAGGGCCAGGGGGCCATCCTGCTGGTGAACTGTGACCGAGAGACACCC
TGGTTGCCCAAGGAGGACTGCCGTGATGAGAAGGTCTACAGCAAGGAAGATCTCAAGGAC
ATGTCCCAGATGATCCTGCGGACCAAAGGCCCCGACCGCCTCCCCGCCGGATACGAGATA
GTTCTGTACATTTCCATGTCAGACTCAGACAAAGTGGGCGTGTTCTACGTGGAGAACCCG
TTCTTCGGCCAACGCTATATCCACATCCTGGGCCGGCGGAAGCTCTACCATGTGGTCAAG
TACACGGGTGGCTCCGCGGAGCTGCTGTTCTTCGTGGAAGGCCTCTGTTTCCCCGACGAG
GGCTTCTCAGGCCTGGTCTCCATCCATGTCAGCCTGCTGGAGTACATGGCCCAGGACATT
CCCCTGACTCCCATCTTCACGGACACCGTGATATTCCGGATTGCTCCGTGGATCATGACC
CCCAACATCCTGCCTCCCGTGTCGGTGTTTGTGTGCTGCATGAAGGATAATTACCTGTTC
CTGAAAGAGGTGAAGAACCTTGTGGAGAAAACCAACTGTGAGCTGAAGGTCTGCTTCCAG
TACCTAAACCGAGGCGATCGCTGGATCCAGGATGAAATTGAGTTTGGCTACATCGAGGCC
CCCCATAAAGGCTTCCCCGTGGTGCTGGACTCTCCCCGAGATGGAAACCTAAAGGACTTC
CCTGTGAAGGAGCTCCTGGGCCCAGATTTTGGCTACGTGACCCGGGAGCCCCTCTTTGAG
TCTGTCACCAGCCTTGACTCATTTGGAAACCTGGAGGTCAGTCCCCCAGTGACCGTGAAC
GGCAAGACATACCCGCTTGGCCGCATCCTCATCGGGAGCAGCTTTCCTCTGTCTGGTGGT
CGGAGGATGACCAAGGTGGTGCGTGACTTCCTGAAGGCCCAGCAGGTGCAGGCACCCGTG
GAGCTCTACTCAGACTGGCTGACTGTGGGCCACGTGGATGAGTTCATGTCCTTTGTCCCC
ATCCCCGGCACAAAGAAATTCCTGCTACTCATGGCCAGCACCTCGGCCTGCTACAAGCTC
TTCCGAGAGAAGCAGAAGGACGGCCATGGAGAGGCCATCATGTTCAAAGGCTTGGGTGGG
ATGAGCAGCAAGCGAATCACCATCAACAAGATTCTGTCCAACGAGAGCCTTGTGCAGGAG
AACCTGTACTTCCAGCGCTGCCTGGACTGGAACCGTGACATCCTCAAGAAGGAGCTGGGA
CTGACAGAGCAGGACATCATTGACCTGCCCGCTCTGTTCAAGATGGACGAGGACCACCGT
GCCAGAGCCTTCTTCCCAAACATGGTGAACATGATCGTGCTGGACAAGGACCTGGGCATC
CCCAAGCCATTCGGGCCACAGGTTGAGGAGGAATGCTGCCTGGAGATGCACGTGCGTGGC
CTCCTGGAGCCCCTGGGCCTCGAATGCACCTTCATCGACGACATTTCTGCCTACCACAAA
TTTCTGGGGGAAGTCCACTGTGGCACCAACGTCCGCAGGAAGCCCTTCACCTTCAAGTGG
TTGCACATGGTGCCCTGA

# Metabolic_Enzyme_35_GenBank_ID_Gene:
AB030176

# Metabolic_Enzyme_35_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_35_Locus:
1p36.13

# Metabolic_Enzyme_35_SNPs:
rs2076595; rs2076615; rs11581590; rs3818032; rs2057096; rs11203297; rs35184728; rs2235926; rs2647176; rs2076598; rs2076599; rs2235917; rs2076611; rs2311483; rs2057092; rs742798; rs2076617; rs2295052; rs2076614; rs2235923; rs2235918; rs742797; rs2746515; rs2746510; rs2235910; rs2076607; rs1005753; rs2235925; rs2235913; rs1980509; rs2244949; rs2014725; rs2076616; rs2647174; rs2235920; rs1883912; rs4920337; rs2647190; rs2076597; rs2647189; rs2057095; rs1569755; rs3818040; rs2295050; rs2295053; rs910232; rs11203298; rs2235924; rs4448563; rs2235919; rs1022579; rs3818039; rs2235909; rs2057093; rs878270; rs910228; rs2143810; rs2076596; rs2295051; rs3818021; rs3818034; rs2014719; rs2647203; rs2647187; rs878269; rs2076609; rs2746529; rs875219; rs910229; rs2016693; rs6663485; rs3818037; rs2235914; rs730387; rs737428; rs2647192; rs2273111; rs875218; rs2076613; rs1980510; rs2076608; rs2746517; rs2243403; rs2076610; rs11587313; rs3818038; rs3818033; rs1883913; rs2647194; rs910233; rs2014718; rs3818042; rs910224; rs6701620; rs2076612; rs2235911; rs10788656; rs910230; rs11203295; rs9435751; rs733785; rs932454; rs9435753; rs1810519; rs11587487; rs9435752; rs2235922; rs3818031; rs910234; rs761426; rs2746495; rs2295046; rs3818036; rs16862492; rs2647197; rs3853182; rs12562528; rs10887996; rs910231; rs3818035; rs3818041; rs1980508; rs932453; rs2311481; rs2647184; rs2746508; rs2746500; rs2746509; rs2076594; rs3818029; rs2295045; rs11203299; rs7528156; rs2647198; rs7547459; rs761427; rs11203300; rs2244416; rs12759261; rs2746524; rs12138566; rs12134165; rs4920499; rs2746518; rs2295048; rs2647183; rs2746531; rs11203293; rs2057091; rs2018865; rs12750541; rs7514768; rs11588995; rs2057094; rs3818028; rs742796; rs2746493; rs2235915; rs2746506; rs2647199; rs11203301; rs2746523; rs2295054; rs2647172; rs2235912; rs2746496; rs2746504; rs2057090; rs6701159; rs11585299; rs7527697; rs11587943; rs12138461; rs12134154; rs2746501; rs12760512; rs761428; rs3818048; rs7530720; rs2281375; rs2647204; rs2295047; rs11805924; rs2746514; rs2647196; rs2746516; rs6675839; rs2746507; rs2143809; rs16862487; rs7523483; rs2647185; rs12411274; rs11576552; rs2647200; rs7523863; rs12134161; rs3830849; rs2235916; rs3818024; rs2281371; rs10887995; rs2235927; rs10157387; rs12133334; rs10157828; rs2746533; rs7516087; rs7515926; rs34847454; rs28537669; rs34737582; rs41306576; rs12747805; rs35341457; rs35674150; rs10649306; rs35108553; rs35030632; rs2746526; rs11203296; rs12748792; rs3036925; rs2746503; rs6684135; rs34902742; rs35540201; rs2647195; rs2746525; rs3215573; rs35413530; rs35821832; rs34454132; rs11378857; rs5772746; rs2746519; rs2746512; rs9435678; rs12085708; rs5772745; rs35004594; rs2235921; rs11811281; rs12734680; rs35155795; rs9730696; rs35828042; rs35113591; rs34076449; rs4989050; rs35342519; rs7534962; rs2746494; rs3036950; rs2647173; rs11368051; rs2746497; rs34270969; rs7511776; rs35868646; rs35960604; rs12058264; rs12754937; rs7528576; rs34687070; rs2746511; rs9435679; rs2295049; rs34532867; rs2647202; rs3036927; rs12138095; rs2647186; rs12130579; rs2647191; rs10562890; rs28396974; rs34818115; rs11380769; rs11382317; rs35136759; rs2647205; rs34698547; rs36117244; rs11415862; rs28580781; rs12094327; rs5772744; rs12741570; rs3036949; rs35779977; rs35961895; rs12090019; rs12024925; rs2647171; rs9725028; rs2281373; rs3036928; rs2746527; rs2295055; rs2092615; rs2647193; rs35040835; rs2647175; rs12760872; rs35479817; rs12062472; rs34849915; rs12081625; rs35030672; rs2647201; rs742795; rs35231839; rs2746522; rs6698353; rs35627406; rs12735968; rs2647206; rs12755767; rs35868287; rs2746502; rs35210292; rs2746505; rs9725030; rs35036779; rs2179794; rs34438749; rs2647170; rs28736624; rs11270306; rs7534768; rs2746499; rs11586592; rs12732522; rs2019192; rs33945320; rs2281372; rs34391605; rs6662829; rs34778293; rs5772747; rs41306574; rs35705744; rs3036954; rs36091753; rs34731873; rs3036923; rs35058101; rs2746492; rs7516094; rs34129774; rs35023393; rs34043625; rs1007282; rs11203290; rs11203292; rs12078020; rs12126285; rs12134582; rs12404121; rs12728190; rs1569753; rs2143811; rs2647177; rs2647180; rs2746534; rs2746535; rs2746542; rs2746543; rs2746544; rs34410889; rs4920442

# Metabolic_Enzyme_35_General_References:
10231032

# Metabolic_Enzyme_35_References:
Not Available

# Metabolic_Enzyme_36_ID:
5958

# Metabolic_Enzyme_36_Name:
GMP reductase 1

# Metabolic_Enzyme_36_Synonyms:
Guanosine 5'-monophosphate oxidoreductase 1; Guanosine monophosphate reductase 1

# Metabolic_Enzyme_36_Gene_Name:
GMPR

# Metabolic_Enzyme_36_Protein_Sequence:
>GMP reductase 1
MPRIDADLKLDFKDVLLRPKRSSLKSRAEVDLERTFTFRNSKQTYSGIPIIVANMDTVGT
FEMAAVMSQHSMFTAIHKHYSLDDWKLFATNHPECLQNVAVSSGSGQNDLEKMTSILEAV
PQVKFICLDVANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGV
GPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCPGDVAKAFGAGADFVM
LGGMFSGHTECAGEVFERNGRKLKLFYGMSSDTAMNKHAGGVAEYRASEGKTVEVPYKGD
VENTILDILGGLRSTCTYVGAAKLKELSRRATFIRVTQQHNTVFS

# Metabolic_Enzyme_36_Number_of_Residues:
345

# Metabolic_Enzyme_36_Molecular_Weight:
37419

# Metabolic_Enzyme_36_Theoretical_pI:
7.08

# Metabolic_Enzyme_36_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on NADH or NADPH
Function:  oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor
Function:  GMP reductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_36_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_36_Specific_Function:
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides

# Metabolic_Enzyme_36_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_36_Reaction:
inosine 5'-phosphate + ammonia + NADP+ = guanosine 5'-phosphate + NADPH + H+

# Metabolic_Enzyme_36_Pfam_Domain_Function:
PF00478:IMPDH

# Metabolic_Enzyme_36_Signals:
None

# Metabolic_Enzyme_36_Transmembrane_Regions:
None

# Metabolic_Enzyme_36_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_36_EC_Link:
EC 1.7.1.7

# Metabolic_Enzyme_36_GenBank_ID_Protein:
529232

# Metabolic_Enzyme_36_SwissProt_ID:
GMPR1_HUMAN (P36959)

# Metabolic_Enzyme_36_swissprot_Name:
Not Available

# Metabolic_Enzyme_36_Genecard_id:
GMPR

# Metabolic_Enzyme_36_Geneatlas_id:
GMPR

# Metabolic_Enzyme_36_hgnc_id:
HGNC:4376

# Metabolic_Enzyme_36_PDB_ID:
2BLE

# Metabolic_Enzyme_36_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_36_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_36_Subcellular_Location:
Not Available

# Metabolic_Enzyme_36_Gene_Sequence:
>87 bp
ATGCCCCGCATAGATGCGGACCTCAAGCTCGACTTCAAGGATGTCCTGCTCCGACCTAAG
CGGAGCAGCCTCAAGAGCCGAGCCGAG

# Metabolic_Enzyme_36_GenBank_ID_Gene:
L35304

# Metabolic_Enzyme_36_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_36_Locus:
6p23

# Metabolic_Enzyme_36_SNPs:
Not Available

# Metabolic_Enzyme_36_General_References:
2758468; 1661705; 14574404; 1757097

# Metabolic_Enzyme_36_References:
Not Available

# Metabolic_Enzyme_37_ID:
5959

# Metabolic_Enzyme_37_Name:
Formimidoyltransferase-cyclodeaminase

# Metabolic_Enzyme_37_Synonyms:
Formiminotransferase- cyclodeaminase; FTCD; LCHC1[Includes: Glutamate formimidoyltransferase; Glutamate formiminotransferase; Glutamate formyltransferase; Formimidoyltetrahydrofolate cyclodeaminase; Formiminotetrahydrofolate cyclodeaminase]

# Metabolic_Enzyme_37_Gene_Name:
FTCD

# Metabolic_Enzyme_37_Protein_Sequence:
>Formimidoyltransferasecyclodeaminase
MSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVE
GALNAARVASRLIDMSRHQGEHPRMGALDVCPFIPVRGVSVDECVLCAQAFGQRLAEELD
VPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGARK
FLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLD
FEVTALHTVYEETCREAQELSLPVVGSQLVGLVPLKALLDAAAFYCEKENLFILEEEQRI
RLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGSVA
AAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYL
EAMRLPKNTPEEKDRRTAALQEGLRRAVSVPLTLAETVASLWPALQELARCGNLACRSDL
QVAAKALEMGVFGAYFNVLINLRDITDEAFKDQIHHRVSSLLQEAKTQAALVLDCLETRQ
E

# Metabolic_Enzyme_37_Number_of_Residues:
541

# Metabolic_Enzyme_37_Molecular_Weight:
58927

# Metabolic_Enzyme_37_Theoretical_pI:
5.45

# Metabolic_Enzyme_37_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  binding
Function:  vitamin binding
Function:  folic acid binding
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_37_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_37_Specific_Function:
Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool

# Metabolic_Enzyme_37_Pathway:
map00670  One carbon pool by folate

# Metabolic_Enzyme_37_Reaction:
5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3

# Metabolic_Enzyme_37_Pfam_Domain_Function:
PF02971:FTCD;
PF04961:FTCD_C;
PF07837:FTCD_N

# Metabolic_Enzyme_37_Signals:
None

# Metabolic_Enzyme_37_Transmembrane_Regions:
None

# Metabolic_Enzyme_37_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_37_EC_Link:
EC 2.1.2.5;EC 4.3.1.4

# Metabolic_Enzyme_37_GenBank_ID_Protein:
6537208

# Metabolic_Enzyme_37_SwissProt_ID:
FTCD_HUMAN (O95954)

# Metabolic_Enzyme_37_swissprot_Name:
Not Available

# Metabolic_Enzyme_37_Genecard_id:
FTCD

# Metabolic_Enzyme_37_Geneatlas_id:
FTCD

# Metabolic_Enzyme_37_hgnc_id:
HGNC:3974

# Metabolic_Enzyme_37_PDB_ID:
Not Available

# Metabolic_Enzyme_37_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_37_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_37_Subcellular_Location:
Cytoplasm. Golgi apparatus (By similarity)

# Metabolic_Enzyme_37_Gene_Sequence:
>1626 bp
ATGTCCCAGCTGGTGGAATGCGTCCCCAACTTTTCGGAGGGGAAGAACCAGGAGGTGATC
GACGCCATCTCTGGAGCCATCACACAGACCCCGGGCTGCGTGCTGCTGGATGTGGACGCA
GGCCCTTCCACCAACCGCACCGTGTACACCTTCGTGGGGCCGCCGGAGTGCGTGGTGGAG
GGGGCCCTCAACGCTGCCCGGGTAGCTTCCCGACTTATCGACATGAGCAGGCACCAAGGA
GAGCACCCCCGCATGGGGGCCCTAGACGTCTGCCCCTTCATCCCCGTGAGGGGCGTCAGC
GTGGATGAGTGTGTGCTCTGCGCCCAGGCCTTTGGCCAGAGGCTGGCAGAGGAGCTGGAC
GTGCCAGTTTACCTGTACGGCGAGGCAGCCAGGATGGACAGTCGCCGGACCCTGCCGGCC
ATCCGGGCCGGGGAGTACGAGGCCCTCCCTAAGAAGCTCCAGCAGGCCGACTGGGCGCCC
GACTTTGGTCCCAGCTCCTTTGTCCCCAGTTGGGGGGCCACGGCCACGGGGGCGAGGAAG
TTCCTCATTGCTTTTAACATCAACCTGCTCGGCACAAAGGAGCAAGCCCACCGCATCGCG
CTCAACCTGCGGGAGCAGGGCCGCGGGAAGGACCAGCCAGGACGTCTGAAGAAAGTTCAG
GGCATTGGCTGGTACCTGGATGAGAAGAACCTGGCTCAGGTGTCCACCAATCTTCTGGAC
TTTGAGGTCACGGCACTGCACACGGTCTACGAGGAGACCTGCCGAGAAGCACAGGAGCTG
AGCCTCCCAGTGGTGGGCTCACAGCTGGTGGGCCTGGTGCCCCTGAAGGCTCTGCTGGAT
GCGGCCGCCTTCTACTGCGAGAAGGAGAACCTCTTCATCCTGGAGGAGGAGCAGCGGATC
AGGCTGGTGGTGAGCCGGCTGGGCCTGGACTCCCTGTGCCCCTTCAGCCCTAAGGAGCGG
ATCATCGAGTACCTGGTCCCTGAGCGCGGGCCTGAGCGAGGCCTGGGCAGCAAGTCCCTG
CGCGCCTTCGTGGGGGAGGTGGGTGCCCGCTCTGCGGCCCCCGGGGGCGGCTCGGTGGCG
GCGGCCGCTGCGGCCATGGGTGCGGCGCTGGGCTCCATGGTGGGCCTCATGACCTACGGG
CGGCGCCAATTCCAGTCCCTGGACACGACGATGCGGCGCCTGATCCCGCCCTTCCGCGAG
GCTTCGGCCAAGCTAACCACGCTGGTGGATGCCGACGCCGAGGCCTTCACCGCCTACCTG
GAAGCAATGAGGCTCCCCAAGAACACACCTGAGGAAAAGGACAGGCGCACGGCGGCCCTA
CAGGAGGGTCTGAGGCGGGCAGTCTCTGTGCCGCTGACGCTGGCGGAGACGGTGGCCTCG
CTGTGGCCGGCGCTGCAGGAACTGGCCCGGTGTGGGAACCTGGCCTGCCGGTCAGACCTC
CAGGTGGCGGCCAAAGCCCTGGAGATGGGCGTGTTTGGCGCATATTTCAACGTGCTCATC
AACCTGAGGGACATCACAGACGAGGCATTTAAGGACCAGATCCACCATCGTGTTTCCAGC
CTCCTGCAGGAAGCCAAGACCCAGGCTGCACTGGTGCTGGACTGCTTGGAGACCCGGCAG
GAGTGA

# Metabolic_Enzyme_37_GenBank_ID_Gene:
AF169017

# Metabolic_Enzyme_37_Chromosome_Location:
Not Available

# Metabolic_Enzyme_37_Locus:
Not Available

# Metabolic_Enzyme_37_SNPs:
rs10432965; rs2277821; rs12774; rs1047209; rs2839127; rs2839126; rs725976; rs2277820; rs7282864; rs9976772; rs2839124; rs1556341; rs1980983; rs9978174; rs7277617; rs11908960; rs2010958; rs7279849; rs9974320; rs17292975; rs2839125; rs4819208; rs17004505; rs8126678; rs11909944; rs17004504; rs8134417; rs16978935; rs4819207; rs11911736; rs9284510; rs1556340; rs16978930; rs9974226; rs3746999; rs17004506; rs11911593; rs16978932; rs4484116; rs1556339; rs11089051; rs4819209; rs914245; rs914246; rs8128111; rs8128270; rs7276274; rs28941768; rs8133955; rs1047179; rs34762382; rs35337947; rs9653792; rs9653793; rs33926654; rs2277819; rs8133080; rs4818824; rs34248722; rs34788232; rs35123061; rs7278881; rs9984474; rs28413731; rs7275864; rs9983829; rs34823397; rs4819206; rs3747000; rs35273895; rs4819205; rs9978647; rs36026689; rs12482309; rs9982796; rs2277818; rs9981364; rs7283985; rs5844255; rs13052919; rs34564917; rs12627256; rs3057182; rs8134628; rs3057172; rs4819204; rs3746998; rs34007993; rs8133524; rs4818825; rs8131374; rs28437812; rs8131105; rs10594439; rs11089050; rs11283939; rs9974540; rs8127720; rs11701284; rs35899631; rs35655527; rs11909099; rs11279411; rs35208133; rs10188; rs1042930; rs1044598; rs11908812; rs11908934; rs11909205; rs11910483; rs12329660; rs12329865; rs12482002; rs12626197; rs12626732; rs12626746; rs13050201; rs13050660; rs14378; rs16978878; rs16978880; rs16978895; rs16978897; rs16978913; rs17272947; rs17292141; rs2236492; rs2839115; rs2839116; rs2839117; rs2839118; rs2839119; rs2839120; rs2839121; rs2839122; rs2839123; rs34433115; rs35139588; rs35548026; rs35887009; rs3746997; rs3747001; rs3747002; rs3747003; rs4819210; rs559; rs6518273; rs6652; rs7280396; rs7280485; rs7281816; rs7282065; rs7717; rs8126854; rs9974913; rs9976171; rs9977394; rs9977572; rs9977766; rs9980548

# Metabolic_Enzyme_37_General_References:
10773664; 10029623; 12815595

# Metabolic_Enzyme_37_References:
Not Available

# Metabolic_Enzyme_38_ID:
5803

# Metabolic_Enzyme_38_Name:
Activation-induced cytidine deaminase

# Metabolic_Enzyme_38_Synonyms:
Cytidine aminohydrolase

# Metabolic_Enzyme_38_Gene_Name:
AICDA

# Metabolic_Enzyme_38_Protein_Sequence:
>Activationinduced cytidine deaminase
MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSLDFGYLRNKNGCHVELL
FLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTARLYFCEDRK
AEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFKAWEGLHENSVRLSRQLRRIL
LPLYEVDDLRDAFRTLGL

# Metabolic_Enzyme_38_Number_of_Residues:
198

# Metabolic_Enzyme_38_Molecular_Weight:
23954

# Metabolic_Enzyme_38_Theoretical_pI:
9.66

# Metabolic_Enzyme_38_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_38_General_Function:
Not Available

# Metabolic_Enzyme_38_Specific_Function:
RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses

# Metabolic_Enzyme_38_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_38_Reaction:
cytidine + H2O = uridine + ammonia

# Metabolic_Enzyme_38_Pfam_Domain_Function:
PF05240:APOBEC_C;
PF08210:APOBEC_N

# Metabolic_Enzyme_38_Signals:
None

# Metabolic_Enzyme_38_Transmembrane_Regions:
None

# Metabolic_Enzyme_38_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_38_EC_Link:
EC 3.5.4.5

# Metabolic_Enzyme_38_GenBank_ID_Protein:
9988410

# Metabolic_Enzyme_38_SwissProt_ID:
AICDA_HUMAN (Q9GZX7)

# Metabolic_Enzyme_38_swissprot_Name:
Not Available

# Metabolic_Enzyme_38_Genecard_id:
AICDA

# Metabolic_Enzyme_38_Geneatlas_id:
AICDA

# Metabolic_Enzyme_38_hgnc_id:
HGNC:13203

# Metabolic_Enzyme_38_PDB_ID:
Not Available

# Metabolic_Enzyme_38_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_38_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_38_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_38_Gene_Sequence:
>597 bp
ATGGACAGCCTCTTGATGAACCGGAGGAAGTTTCTTTACCAATTCAAAAATGTCCGCTGG
GCTAAGGGTCGGCGTGAGACCTACCTGTGCTACGTAGTGAAGAGGCGTGACAGTGCTACA
TCCTTTTCACTGGACTTTGGTTATCTTCGCAATAAGAACGGCTGCCACGTGGAATTGCTC
TTCCTCCGCTACATCTCGGACTGGGACCTAGACCCTGGCCGCTGCTACCGCGTCACCTGG
TTCACCTCCTGGAGCCCCTGCTACGACTGTGCCCGACATGTGGCCGACTTTCTGCGAGGG
AACCCCAACCTCAGTCTGAGGATCTTCACCGCGCGCCTCTACTTCTGTGAGGACCGCAAG
GCTGAGCCCGAGGGGCTGCGGCGGCTGCACCGCGCCGGGGTGCAAATAGCCATCATGACC
TTCAAAGATTATTTTTACTGCTGGAATACTTTTGTAGAAAACCATGAAAGAACTTTCAAA
GCCTGGGAAGGGCTGCATGAAAATTCAGTTCGTCTCTCCAGACAGCTTCGGCGCATCCTT
TTGCCCCTGTATGAGGTTGATGACTTACGAGACGCATTTCGTACTTTGGGACTTTGA

# Metabolic_Enzyme_38_GenBank_ID_Gene:
AB040431

# Metabolic_Enzyme_38_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_38_Locus:
12p13

# Metabolic_Enzyme_38_SNPs:
rs2028373; rs12307097; rs11046349; rs7304723; rs2580874; rs2518144; rs2580873; rs1561560; rs2580875; rs12306110; rs1561559; rs2580876; rs3794318; rs17792729; rs1347978; rs3794316; rs1439868; rs2165191; rs3794317; rs11613792; rs1561562; rs1561561; rs714629; rs7316523; rs9971686; rs1561557; rs12297074; rs2019057; rs9971703; rs714630; rs3205190; rs10601618; rs34604633; rs11324989; rs7138990; rs35273657; rs10623739; rs12310085; rs28681214; rs11614281; rs5796316; rs1439869; rs12307620; rs34730872; rs12312451; rs5796317; rs33998240; rs35699718; rs1982214; rs12321976; rs34030304; rs1561558; rs1345004; rs9971705; rs28835914; rs12321209; rs12824576; rs2889653; rs7305961; rs7306108

# Metabolic_Enzyme_38_General_References:
10950930; 11007475; 11544457

# Metabolic_Enzyme_38_References:
Not Available

# Metabolic_Enzyme_39_ID:
5960

# Metabolic_Enzyme_39_Name:
Protein-arginine deiminase type-1

# Metabolic_Enzyme_39_Synonyms:
Protein-arginine deiminase type I; Peptidylarginine deiminase I

# Metabolic_Enzyme_39_Gene_Name:
PADI1

# Metabolic_Enzyme_39_Protein_Sequence:
>Proteinarginine deiminase type1
MAPKRVVQLSLKMPTHAVCVVGVEAHVDIHSDVPKGANSFRVSGSSGVEVFMVYNRTRVK
EPIGKARWPLDTDADMVVSVGTASKELKDFKVRVSYFGEQEDQALGRSVLYLTGVDISLE
VDTGRTGKVKRSQGDKKTWRWGPEGYGAILLVNCDRDNHRSAEPDLTHSWLMSLADLQDM
SPMLLSCNGPDKLFDSHKLVLNVPFSDSKRVRVFCARGGNSLSDYKQVLGPQCLSYEVER
QPGEQEIKFYVEGLTFPDADFLGLVSLSVSLVDPGTLPEVTLFTDTVGFRMAPWIMTPNT
QPPEELYVCRVMDTHGSNEKFLEDMSYLTLKANCKLTICPQVENRNDRWIQDEMEFGYIE
APHKSFPVVFDSPRNRGLKDFPYKRILGPDFGYVTREIPLPGPSSLDSFGNLDVSPPVTV
GGTEYPLGRILIGSSFPKSGGRQMARAVRNFLKAQQVQAPVELYSDWLSVGHVDEFLTFV
PTSDQKGFRLLLASPSACLKLFQEKKEEGYGEAAQFDGLKHQAKRSINEMLADRHLQRDN
LHAQKCIDWNRNVLKRELGLAESDIVDIPQLFFLKNFYAEAFFPDMVNMVVLGKYLGIPK
PYGPIINGRCCLEEKVQSLLEPLGLHCIFIDDYLSYHELQGEIHCGTNVRRKPFPFKWWN
MVP

# Metabolic_Enzyme_39_Number_of_Residues:
663

# Metabolic_Enzyme_39_Molecular_Weight:
74666

# Metabolic_Enzyme_39_Theoretical_pI:
6.46

# Metabolic_Enzyme_39_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Function:  protein-arginine deiminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_39_General_Function:
Not Available

# Metabolic_Enzyme_39_Specific_Function:
Catalyzes the deimination of arginine residues of proteins

# Metabolic_Enzyme_39_Pathway:
Not Available

# Metabolic_Enzyme_39_Reaction:
protein L-arginine + H2O = protein L-citrulline + NH3

# Metabolic_Enzyme_39_Pfam_Domain_Function:
PF03068:PAD;
PF08527:PAD_M;
PF08526:PAD_N

# Metabolic_Enzyme_39_Signals:
1-17

# Metabolic_Enzyme_39_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_39_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_39_EC_Link:
EC 3.5.3.15

# Metabolic_Enzyme_39_GenBank_ID_Protein:
6116899

# Metabolic_Enzyme_39_SwissProt_ID:
PADI1_HUMAN (Q9ULC6)

# Metabolic_Enzyme_39_swissprot_Name:
Not Available

# Metabolic_Enzyme_39_Genecard_id:
PADI1

# Metabolic_Enzyme_39_Geneatlas_id:
PADI1

# Metabolic_Enzyme_39_hgnc_id:
HGNC:18367

# Metabolic_Enzyme_39_PDB_ID:
Not Available

# Metabolic_Enzyme_39_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_39_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_39_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_39_Gene_Sequence:
>1992 bp
ATGGCCCCAAAGAGAGTTGTGCAGCTGTCCCTGAAGATGCCTACCCATGCCGTGTGTGTG
GTGGGAGTCGAGGCACATGTGGACATTCACAGTGATGTGCCCAAGGGTGCCAACAGCTTC
AGGGTCTCTGGAAGCTCCGGGGTGGAGGTCTTCATGGTCTACAACCGCACACGTGTGAAA
GAGCCCATAGGCAAGGCCCGTTGGCCGCTAGACACTGATGCAGACATGGTCGTATCTGTG
GGCACAGCCAGTAAGGAATTAAAGGACTTCAAGGTGAGGGTCTCCTACTTTGGGGAGCAG
GAAGACCAAGCTCTGGGCCGCAGCGTGCTTTACCTCACTGGCGTCGATATTTCCCTTGAG
GTTGACACAGGCCGCACAGGCAAGGTGAAGAGGAGCCAAGGGGACAAGAAAACCTGGCGC
TGGGGCCCTGAGGGCTATGGGGCTATCTTGCTGGTGAACTGTGACCGGGACAATCACAGG
TCCGCGGAGCCTGACCTCACCCACAGCTGGCTGATGTCGCTGGCTGACCTGCAGGACATG
TCCCCAATGCTGCTGAGCTGCAATGGCCCCGACAAGCTCTTCGACAGCCACAAGCTTGTC
TTGAACGTGCCCTTTTCTGATTCCAAAAGAGTGAGGGTCTTCTGTGCCAGGGGTGGGAAT
TCTCTCTCGGACTACAAACAGGTGCTGGGGCCCCAGTGTCTGTCCTATGAAGTTGAGCGA
CAGCCAGGGGAGCAGGAGATCAAGTTCTATGTGGAGGGGCTGACCTTCCCCGATGCCGAT
TTCCTAGGGCTGGTTTCCCTCAGTGTCAGCCTGGTGGACCCGGGGACCCTGCCCGAGGTG
ACCCTCTTCACAGACACTGTGGGCTTCCGCATGGCCCCCTGGATCATGACGCCCAACACT
CAGCCTCCTGAGGAGCTGTATGTGTGCAGAGTGATGGACACTCATGGCTCCAATGAGAAA
TTCCTGGAGGACATGTCTTATCTGACATTGAAAGCCAACTGCAAGCTGACCATCTGCCCT
CAAGTTGAAAATCGAAATGACCGCTGGATCCAGGACGAGATGGAGTTTGGCTACATCGAG
GCCCCTCACAAATCCTTCCCCGTGGTCTTTGACTCCCCCAGGAACAGGGGCCTGAAAGAT
TTCCCCTATAAGAGGATCCTGGGTCCTGACTTTGGATATGTTACCCGGGAGATCCCGCTC
CCTGGTCCCTCCAGCCTTGACTCCTTCGGCAACCTGGACGTCAGCCCGCCCGTCACGGGG
GGCGGCACGGAATACCCCCTGGGCCGGATCCTCATCGGGAGCAGCTTCCCCAAGTCCGGT
GGGCGGCAGATGGCCAGGGCAGTGCGGAACTTCCTGAAGGCACAGCAGGTGCAGGCACCC
GTGGAGCTCTACTCGGACTGGCTCTCTGTGGGCCATGTGGACGAGTTTCTGACCTTTGTG
CCTACCTCTGACCAGAAGGGCTTCCGGCTGCTCCTGGCTAGCCCCAGCGCTTGCCCCAAA
CTCTTCCAAGAGAAGAAAGAAGAGGGTTATGGGGAGGCAGCCCAGTTTGATGGGTTAAAA
CACCAGGCAAAAAGAAGCATTAATGAGATGCTGGCAGACAGACACCTCCAGAGAGACAAT
CTTCATGCACAGAAATGCATTGACTGGAACCGTAATGTGCTGAAGCGGGAGCTGGGCCTG
GCAGAGAGTGACATCGTGGACATTCCCCAGCTCTTCTTCCTGAAAAACTTCTACGCGGAA
GCCTTCTTCCCAGACATGGTTAACATGGTGGTCTTAGGCAAGTACCTGGGCATCCCCAAG
CCCTACGGGCCCATCATCAATGGCCGCTGCTGCCTGGAGGAGAAGGTGCAGTCCCTGCTG
GAGCCTCTGGGCCTGCACTGCATCTTCATTGATGACTACTTGTCCTACCACGAGCTGCAG
GGGGAGATCCACTGTGGCACCAACGTGCGCAGGAAGCCCTTTCCCTTCAAATGGTGGAAC
ATGGTGCCCTGA

# Metabolic_Enzyme_39_GenBank_ID_Gene:
AB033768

# Metabolic_Enzyme_39_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_39_Locus:
1p36.13

# Metabolic_Enzyme_39_SNPs:
rs16824215; rs2293912; rs3003406; rs2977234; rs11590783; rs2293911; rs3750299; rs2293915; rs3003412; rs2977235; rs2977284; rs2977222; rs2977290; rs3003479; rs4309027; rs6667138; rs3750296; rs11203332; rs6687052; rs4920359; rs4384275; rs2293913; rs2977277; rs12096215; rs12024174; rs11203339; rs2977233; rs12030076; rs12057156; rs11203336; rs2293921; rs4268393; rs3763583; rs3003413; rs2977279; rs2293914; rs10888010; rs2977236; rs2977307; rs2977312; rs16823950; rs3003407; rs2977274; rs3003478; rs11203334; rs3123531; rs2008313; rs10127662; rs3750297; rs3003414; rs2977278; rs11589046; rs11588921; rs2977313; rs3123532; rs3003409; rs12028888; rs2977272; rs2977283; rs2977238; rs4920575; rs10749617; rs3115788; rs12091488; rs4920576; rs3003408; rs3003480; rs3003482; rs11577718; rs2977310; rs3750295; rs4920358; rs2977309; rs10888008; rs2977270; rs4244378; rs11800455; rs2977286; rs12026071; rs12138305; rs2977280; rs2977308; rs878508; rs4244377; rs2977237; rs4376784; rs12135995; rs6679572; rs16823620; rs12086890; rs2977285; rs12125350; rs6682569; rs2977273; rs6674583; rs6682573; rs16824005; rs12408716; rs12024177; rs11203340; rs3003481; rs3115789; rs12096884; rs2977271; rs12087943; rs12044142; rs16823615; rs12401313; rs12042390; rs2977306; rs9970134; rs6656786; rs16823998; rs10888009; rs3750292; rs12119803; rs2977282; rs10888007; rs2293910; rs12073445; rs6665128; rs4920571; rs28706570; rs41265071; rs11203335; rs41265069; rs41300110; rs3003415; rs6679574; rs12735518; rs34130414; rs2977291; rs41265067; rs12086331; rs4994417; rs35549923; rs2977223; rs35408430; rs12082617; rs6143143; rs35930248; rs34306509; rs12097011; rs3003411; rs34749160; rs3003418; rs12042325; rs34512660; rs34284844; rs12042639; rs11203337; rs35924964; rs12080690; rs35818130; rs9970436; rs11588976; rs3003477; rs11203338; rs41265091; rs35756262; rs35665599; rs34703588; rs12730578; rs2977288; rs1006624; rs34647130; rs41265085; rs3003410; rs12746163; rs9919187; rs12046183; rs34961969; rs2977289; rs6681682; rs11267550; rs35593058; rs35573454; rs11576788; rs41265087; rs12735533; rs12062009; rs12081883; rs3763581; rs2977287; rs3003405; rs35823191; rs35724119; rs10538547; rs34562036; rs3003417; rs12135648; rs34182672; rs12730593; rs34242337; rs12729847; rs12082663; rs34739449; rs12730570; rs12752579; rs2977311; rs41265089; rs11203341; rs35500545; rs35116152; rs34169516; rs3003416; rs35269235; rs11579051; rs12134684; rs35482193; rs35854535; rs34799498; rs35372998; rs1012858; rs1015082; rs11203343; rs11581288; rs11581367; rs11583460; rs11583594; rs11583629; rs11584147; rs12025184; rs12058442; rs12065629; rs12072538; rs12077061; rs12077067; rs12129306; rs12404500; rs12562867; rs16824388; rs16824389; rs2454181; rs2454182; rs2501820; rs2935940; rs2935941; rs2977224; rs2977225; rs2977227; rs2977228; rs2977229; rs2977230; rs2977256; rs2977257; rs2977259; rs2977262; rs3003419; rs3003422; rs3003423; rs3003424; rs3003470; rs3003471; rs3003472; rs3003473; rs3003474; rs3003476; rs3763587; rs3763589; rs4451590; rs4462198; rs4494184; rs4920570; rs4920578; rs4920579; rs4920580; rs4920581; rs4920582; rs4920583; rs4920584; rs6586512; rs6673643; rs6694161; rs7522439; rs754171; rs873319; rs873320; rs873321; rs9803868

# Metabolic_Enzyme_39_General_References:
Not Available

# Metabolic_Enzyme_39_References:
Not Available

# Metabolic_Enzyme_40_ID:
5961

# Metabolic_Enzyme_40_Name:
Aminomethyltransferase, mitochondrial precursor

# Metabolic_Enzyme_40_Synonyms:
Glycine cleavage system T protein; GCVT

# Metabolic_Enzyme_40_Gene_Name:
AMT

# Metabolic_Enzyme_40_Protein_Sequence:
>Aminomethyltransferase, mitochondrial precursor
MQRAVSVVARLGFRLQAFPPALCRPLSCAQEVLRRTPLYDFHLAHGGKMVAFAGWSLPVQ
YRDSHTDSHLHTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFT
NEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDNALL
ALQGPTAAQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPVAGA
VHLATAILKNPEVKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAM
DFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPILNMEGTKIGTVTSGCPSPSLKKNV
AMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLK

# Metabolic_Enzyme_40_Number_of_Residues:
403

# Metabolic_Enzyme_40_Molecular_Weight:
43947

# Metabolic_Enzyme_40_Theoretical_pI:
8.69

# Metabolic_Enzyme_40_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  aminomethyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
Process:  glycine catabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_40_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_40_Specific_Function:
The glycine cleavage system catalyzes the degradation of glycine

# Metabolic_Enzyme_40_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00670  One carbon pool by folate;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_40_Reaction:
protein-S-aminomethyldihydrolipoyllysine + tetrahydrofolate = protein-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3

# Metabolic_Enzyme_40_Pfam_Domain_Function:
PF01571:GCV_T;
PF08669:GCV_T_C

# Metabolic_Enzyme_40_Signals:
1-23

# Metabolic_Enzyme_40_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_40_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_40_EC_Link:
EC 2.1.2.10

# Metabolic_Enzyme_40_GenBank_ID_Protein:
391721

# Metabolic_Enzyme_40_SwissProt_ID:
GCST_HUMAN (P48728)

# Metabolic_Enzyme_40_swissprot_Name:
Not Available

# Metabolic_Enzyme_40_Genecard_id:
AMT

# Metabolic_Enzyme_40_Geneatlas_id:
AMT

# Metabolic_Enzyme_40_hgnc_id:
HGNC:473

# Metabolic_Enzyme_40_PDB_ID:
Not Available

# Metabolic_Enzyme_40_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_40_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_40_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_40_Gene_Sequence:
>1212 bp
ATGCAGAGGGCTGTAAGTGTGGTGGCCCGTCTGGGCTTTCGCCTGCAGGCATTCCCCCCG
GCCTTGTGTCGTCCACTTAGTTGCGCACAGGAGGTGCTCCGCAGGACACCGCTCTATGAC
TTCCACCTGGCCCACGGCGGGAAAATGGTGGCGTTTGCGGGTTGGAGTCTGCCAGTGCAG
TACCGGGACAGTCACACTGACTCGCACCTGCACACACGCCAGCACTGCTCGCTCTTTGAC
GTGTCTCATATGCTGCAGACCAAGATACTTGGTAGTGACCGGGTGAAGCTGATGGAGAGT
CTAGTGGTTGGAGACATTGCAGAGCTAAGACCAAACCAGGGGACACTGTCGCTGTTTACC
AACGAGGCTGGAGGCATCTTAGATGACTTGATTGTAACCAATACTTCTGAGGGCCACCTG
TATGTGGTGTCCAACGCTGGCTGCTGGGAGAAAGATTTGGCCCTCATGCAGGACAAGGTC
AGGGAGCTTCAGAACCAGGGCAGAGATGTGGGCCTGGAGGTGTTGGATAATGCCCTGCTA
GCTCTGCAAGGCCCCACTGCAGCCCAGGTACTACAGGCCGGCGTGGCAGATGACCTGAGG
AAACTGCCCTTCATGACCAGTGCTGTGATGGAGGTGTTTGGCGTGTCTGGCTGCCGCGTG
ACCCGCTGTGGCTACACAGGAGAGGATGGTGTGGAGATCTCGGTGCCGGTAGCGGGGGCA
GTTCACCTGGCAACAGCTATTCTGAAAAACCCAGAGGTGAAGCTGGCAGGGCTGGCAGCC
AGGGACAGCCTGCGCCTGGAGGCAGGCCTCTGCCTGTATGGGAATGACATTGATGAACAC
ACTACACCTGTGGAGGGCAGCCTCAGTTGGACACTGGGGAAGCGCCGCCGAGCTGCTATG
GACTTCCCTGGAGCCAAGGTCATTGTTCCCCAGCTGAAGGGCAGGGTGCAGCGGAGGCGT
GTGGGGTTGATGTGTGAGGGGGCCCCCATGCGGGCACACAGTCCCATCCTGAACATGGAG
GGTACCAAGATTGGTACTGTGACTAGTGGCTGCCCCTCCCCCTCTCTGAAGAAGAATGTG
GCGATGGGTTATGTGCCCTGCGAGTACAGTCGTCCAGGGACAATGCTGCTGGTAGAGGTG
CGGCGGAAGCAGCAGATGGCTGTAGTCAGCAAGATGCCCTTTGTGCCCACAAACTACTAT
ACCCTCAAGTGA

# Metabolic_Enzyme_40_GenBank_ID_Gene:
D13811

# Metabolic_Enzyme_40_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_40_Locus:
3p21.2-p21.1

# Metabolic_Enzyme_40_SNPs:
rs11715915; rs1464567; rs1464568; rs4855873; rs9859556; rs11922013; rs1041964; rs34568346; rs13095834; rs3049036; rs34457565; rs35024166; rs11425937; rs10640; rs11130192; rs11710609; rs1464566; rs1464569; rs1522929; rs1803637; rs1996874; rs34812788; rs4855874; rs4855877; rs6446272; rs6446273; rs6762593; rs6779432; rs6779524; rs6784820; rs6997; rs8897; rs940045; rs9814873

# Metabolic_Enzyme_40_General_References:
7916605; 8188235; 8005589; 9600239; 9621520; 10873393; 11286506

# Metabolic_Enzyme_40_References:
Not Available

# Metabolic_Enzyme_41_ID:
5962

# Metabolic_Enzyme_41_Name:
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

# Metabolic_Enzyme_41_Synonyms:
Spermatogenic glyceraldehyde-3-phosphate dehydrogenase; Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2; GAPDH-2

# Metabolic_Enzyme_41_Gene_Name:
GAPDHS

# Metabolic_Enzyme_41_Protein_Sequence:
>Glyceraldehyde3phosphate dehydrogenase, testisspecific
MSKRDIVLTNVTVVQLLRQPCPVTRAPPPPEPKAEVEPQPQPEPTPVREEIKPPPPPLPP
HPATPPPKMVSVARELTVGINGFGRIGRLVLRACMEKGVKVVAVNDPFIDPEYMVYMFKY
DSTHGRYKGSVEFRNGQLVVDNHEISVYQCKEPKQIPWRAVGSPYVVESTGVYLSIQAAS
DHISAGAQRVVISAPSPDAPMFVMGVNENDYNPGSMNIVSNASCTTNCLAPLAKVIHERF
GIVEGLMTTVHSYTATQKTVDGPSRKAWRDGRGAHQNIIPASTGAAKAVTKVIPELKGKL
TGMAFRVPTPDVSVVDLTCRLAQPAPYSAIKEAVKAAAKGPMAGILAYTEDEVVSTDFLG
DTHSSIFDAKAGIALNDNFVKLISWYDNEYGYSHRVVDLLRYMFSRDK

# Metabolic_Enzyme_41_Number_of_Residues:
408

# Metabolic_Enzyme_41_Molecular_Weight:
44502

# Metabolic_Enzyme_41_Theoretical_pI:
8.34

# Metabolic_Enzyme_41_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Function:  glyceraldehyde-3-phosphate dehydrogenase activity
Function:  glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_41_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_41_Specific_Function:
May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility

# Metabolic_Enzyme_41_Pathway:
map00010  Glycolysis / Gluconeogenesis

# Metabolic_Enzyme_41_Reaction:
D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+

# Metabolic_Enzyme_41_Pfam_Domain_Function:
PF02800:Gp_dh_C;
PF00044:Gp_dh_N

# Metabolic_Enzyme_41_Signals:
None

# Metabolic_Enzyme_41_Transmembrane_Regions:
None

# Metabolic_Enzyme_41_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_41_EC_Link:
EC 1.2.1.12

# Metabolic_Enzyme_41_GenBank_ID_Protein:
3046742

# Metabolic_Enzyme_41_SwissProt_ID:
G3PT_HUMAN (O14556)

# Metabolic_Enzyme_41_swissprot_Name:
Not Available

# Metabolic_Enzyme_41_Genecard_id:
GAPDHS

# Metabolic_Enzyme_41_Geneatlas_id:
GAPDHS

# Metabolic_Enzyme_41_hgnc_id:
HGNC:24864

# Metabolic_Enzyme_41_PDB_ID:
Not Available

# Metabolic_Enzyme_41_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_41_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_41_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_41_Gene_Sequence:
>1227 bp
ATGTCGAAGCGCGACATCGTCCTCACCAATGTCACCGTTGTCCAGTTGCTGCGACAGCCG
TGCCCGGTGACCAGAGCACCGCCCCCACCTGAGCCTAAGGCTGAAGTAGAGCCCCAGCCA
CAACCAGAGCCCACACCAGTCAGGGAGGAAATAAAGCCACCACCGCCACCACTGCCTCCT
CACCCCGCTACTCCTCCTCCTAAGATGGTGTCTGTGGCCCGGGAGCTGACTGTGGGCATC
AATGGATTTGGACGCATCGGTCGCCTGGTCCTGCGCGCCTGCATGGAGAAGGGTGTTAAG
GTGGTGGCTGTGAATGATCCATTCATTGACCCGGAATACATGGTGTACATGTTTAAGTAT
GACTCCACCCACGGCCGATACAAGGGAAGTGTGGAATTCAGGAATGGACAACTGGTCGTG
GACAACCATGAGATCTCTGTCTACCAGTGCAAAGAGCCCAAACAGATCCCCTGGAGGGCT
GTCGGGAGCCCCTACGTGGTGGAGTCCACAGGCGTGTACCTCTCCATACAGGCAGCTTCG
GACCACATCTCTGCAGGTGCTCAACGTGTGGTCATCTCCGCGCCCTCACCGGATGCACCA
ATGTTCGTCATGGGTGTCAATGAAAATGACTATAACCCTGGCTCCATGAACATTGTGAGC
AACGCGTCCTGCACCACCAACTGTTTGGCTCCCCTCGCCAAAGTCATCCACGAGCGATTT
GGGATCGTGGAAGGGTTGATGACCACAGTCCATTCCTACACGGCCACCCAGAAGACAGTG
GACGGGCCATCAAGGAAGGCCTGGCGAGATGGGCGGGGTGCCCACCAGAACATCATCCCA
GCCTCCACTGGGGCTGCGAAAGCTGTGACCAAAGTCATCCCAGAGCTCAAAGGGAAGCTG
ACAGGGATGGCGTTCCGGGTACCAACCCCGGATGTGTCTGTCGTGGACCTGACCTGCCGC
CTCGCCCAGCCTGCCCCCTACTCAGCCATCAAGGAGGCTGTAAAAGCAGCAGCCAAGGGG
CCCATGGCTGGCATCCTTGCCTACACCGAGGATGAGGTCGTCTCTACGGACTTCCTCGGT
GATACCCACTCGTCCATCTTCGATGCTAAGGCCGGCATTGCGCTCAATGACAATTTCGTG
AAGCTCATTTCATGGTACGACAACGAATATGGCTACAGTCACCGGGTGGTCGACCTCCTC
CGCTACATGTTCAGCCGAGACAAGTGA

# Metabolic_Enzyme_41_GenBank_ID_Gene:
AJ005371

# Metabolic_Enzyme_41_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_41_Locus:
19q13.1

# Metabolic_Enzyme_41_SNPs:
rs2239945; rs4806173; rs8100526; rs4806174; rs2239942; rs17705657; rs11882238; rs2293681; rs2239943; rs2871992; rs2239944; rs12984928; rs11668508; rs4806171; rs12608794; rs12151019; rs12151182; rs12150953; rs2285514; rs11882298; rs4442931; rs12985222; rs35758620; rs35395050; rs28590024; rs35558737; rs12985178; rs10532876; rs12978688; rs11084822; rs3216892; rs11403940; rs34411155; rs34297540; rs34305005; rs34495996; rs1029387; rs10420102; rs1044255; rs10775583; rs1127675; rs11878600; rs12611120; rs1269215; rs12977572; rs16970510; rs17638427; rs17705633; rs17776451; rs2251124; rs2251125; rs2285511; rs2285512; rs2285513; rs2301617; rs2733738; rs2733739; rs2733744; rs2854252; rs34044708; rs34081785; rs35486099; rs35586120; rs3815018; rs4805129; rs7599; rs759996; rs8112853

# Metabolic_Enzyme_41_General_References:
10714828

# Metabolic_Enzyme_41_References:
Not Available

# Metabolic_Enzyme_42_ID:
5789

# Metabolic_Enzyme_42_Name:
Cystathionine gamma-lyase

# Metabolic_Enzyme_42_Synonyms:
Gamma-cystathionase

# Metabolic_Enzyme_42_Gene_Name:
CTH

# Metabolic_Enzyme_42_Protein_Sequence:
>Cystathionine gammalyase
MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEY
SRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRY
FRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHG
DIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQ
NSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQH
ELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVL
KNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS

# Metabolic_Enzyme_42_Number_of_Residues:
405

# Metabolic_Enzyme_42_Molecular_Weight:
44508

# Metabolic_Enzyme_42_Theoretical_pI:
6.69

# Metabolic_Enzyme_42_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_42_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_42_Specific_Function:
L-cystathionine + H(2)O = L-cysteine + NH(3) + 2-oxobutanoate

# Metabolic_Enzyme_42_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00271  Methionine metabolism;
 map00272  Cysteine metabolism;
 map00450  Selenoamino acid metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_42_Reaction:
L-cystathionine + H2O = L-cysteine + ammonia + 2-oxobutanoate

# Metabolic_Enzyme_42_Pfam_Domain_Function:
PF01053:Cys_Met_Meta_PP

# Metabolic_Enzyme_42_Signals:
None

# Metabolic_Enzyme_42_Transmembrane_Regions:
None

# Metabolic_Enzyme_42_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_42_EC_Link:
EC 4.4.1.1

# Metabolic_Enzyme_42_GenBank_ID_Protein:
262476

# Metabolic_Enzyme_42_SwissProt_ID:
CGL_HUMAN (P32929)

# Metabolic_Enzyme_42_swissprot_Name:
Not Available

# Metabolic_Enzyme_42_Genecard_id:
CTH

# Metabolic_Enzyme_42_Geneatlas_id:
CTH

# Metabolic_Enzyme_42_hgnc_id:
HGNC:2501

# Metabolic_Enzyme_42_PDB_ID:
Not Available

# Metabolic_Enzyme_42_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_42_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_42_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_42_Gene_Sequence:
>1218 bp
ATGCAGGAAAAAGACGCCTCCTCACAAGGTTTCCTGCCACACTTCCAACATTTCGCCACG
CAGGCGATCCATGTGGGCCAGGATCCGGAGCAATGGACCTCCAGGGCTGTAGTGCCCCCC
ATCTCACTGTCCACCACGTTCAAGCAAGGGGCGCCTGGCCAGCACTCGGGTTTTGAATAT
AGCCGTTCTGGAAATCCCACTAGGAATTGCCTTGAAAAAGCAGTGGCAGCACTGGATGGG
GCTAAGTACTGTTTGGCCTTTGCTTCAGGTTTAGCAGCCACTGTAACTATTACCCATCTT
TTAAAAGCAGGAGACCAAATTATTTGTATGGATGATGTGTATGGAGGTACAAACAGGTAC
TTCAGGCAAGTGGCATCTGAATTTGGATTAAAGATTTCTTTTGTTGATTGTTCCAAAATC
AAATTACTAGAGGCAGCAATTACACCAGAAACCAAGCTTGTTTGGATCGAAACCCCCACA
AACCCCACCCAGAAGGTGATTGACATTGAAGGCTGTGCACATATTGTCCATAAGCATGGA
GACATTATTTTGGTCGTGGATAACACTTTTATGTCACCATATTTCCAGCGCCCTTTGGCT
CTGGGAGCTGATATTTCTATGTATTCTGCAACAAAATACATGAATGGCCACAGTGATGTT
GTAATGGGCCTGGTGTCTGTTAATTGTGAAAGCCTTCATAATAGACTTCGTTTCTTGCAA
AACTCTCTTGGAGCAGTTCCATCTCCTATTGATTGTTACCTCTGCAATCGAGGTCTGAAG
ACTCTACATGTCCGAATGGAAAAGCATTTCAAAAACGGAATGGCAGTTGCCCAGTTCCTG
GAATCTAATCCTTGGGTAGAAAAGGTTATTTATCCTGGGCTGCCCTCTCATCCACAGCAT
GAGTTGGTGAAGCGTCAGTGTACAGGTTGTACAGGGATGGTCACCTTTTATATTAAGGGC
ACTCTTCAGCATGCTGAGATTTTCCTCAAGAACCTAAAGCTATTTACTCTGGCCGAGAGC
TTGGGAGGATTCGAAAGCCTTGCTGAGCTTCCGGCAATCATGACTCATGCATCAGTTCTT
AAGAATGACAGAGATGTCCTTGGAATTAGTGACACACTGATTCGACTTTCTGTGGGCTTA
GAGGATGAGGAAGACCTACTGGAAGATCTAGATCAAGCTTTGAAGGCAGCACACCCTCCA
AGTGGAATTCACAGCTAG

# Metabolic_Enzyme_42_GenBank_ID_Gene:
S52784

# Metabolic_Enzyme_42_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_42_Locus:
1p31.1

# Metabolic_Enzyme_42_SNPs:
rs1021737; rs17131292; rs535112; rs672203; rs663649; rs515064; rs473334; rs681475; rs481654; rs1145920; rs525919; rs6413469; rs4650049; rs525276; rs475263; rs12723350; rs543860; rs1145919; rs487773; rs490574; rs559062; rs501939; rs577476; rs6413471; rs482291; rs3767205; rs11800827; rs12047791; rs12566819; rs35173672; rs6413472; rs1831868; rs34538135; rs35523269; rs35441160; rs828355; rs17131305; rs35356635; rs608609; rs35864483; rs35242276; rs10889869; rs12037405; rs12030275; rs36032119; rs34044393; rs6413470; rs7418870; rs17131304; rs35873591; rs1831869; rs17131302; rs6693082; rs663465; rs648743; rs6677781; rs583316; rs6413468; rs12733999; rs3806385; rs17131290; rs584229; rs28595301; rs41305638; rs28498802; rs12134794; rs4650048; rs11295998; rs10583561; rs17131300; rs6703826; rs7367528; rs5775007; rs34806645; rs41313347; rs12134791; rs35200485; rs11589868; rs12134763; rs35769653; rs6657511; rs10607278; rs12141277; rs34046663; rs11413197; rs34328255; rs6657715; rs34566720; rs34937471; rs34141704; rs35782843; rs5775006; rs4323657; rs13374865; rs12134858; rs12753345; rs562660; rs6413473; rs4649915; rs12133065; rs35606808; rs35199704; rs12134857; rs12124009; rs34612780; rs34825234; rs36059149; rs34311111; rs34465384; rs36065609; rs11590089; rs11803055; rs12026422; rs12063280; rs12093763; rs12561944; rs12728599; rs1697388; rs17131275; rs17131276; rs17131277; rs17131278; rs17131280; rs17131282; rs17131285; rs17131286; rs17131287; rs17131288; rs17131289; rs17131312; rs2151540; rs3856027; rs3856028; rs4650047; rs4650050; rs482843; rs508310; rs517500; rs555671; rs561926; rs618531; rs6424386; rs649346; rs664051; rs7515490; rs7537371; rs7549628

# Metabolic_Enzyme_42_General_References:
1339280; 12574942

# Metabolic_Enzyme_42_References:
Not Available

# Metabolic_Enzyme_43_ID:
5963

# Metabolic_Enzyme_43_Name:
Guanine deaminase

# Metabolic_Enzyme_43_Synonyms:
Guanase; Guanine aminase; Guanine aminohydrolase; GAH; p51-nedasin

# Metabolic_Enzyme_43_Gene_Name:
GDA

# Metabolic_Enzyme_43_Protein_Sequence:
>Guanine deaminase
MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF
KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA
EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY
KETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSH
ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH
CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE
KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI
SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV

# Metabolic_Enzyme_43_Number_of_Residues:
454

# Metabolic_Enzyme_43_Molecular_Weight:
51004

# Metabolic_Enzyme_43_Theoretical_pI:
5.45

# Metabolic_Enzyme_43_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_43_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_43_Specific_Function:
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia

# Metabolic_Enzyme_43_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_43_Reaction:
guanine + H2O = xanthine + ammonia

# Metabolic_Enzyme_43_Pfam_Domain_Function:
PF01979:Amidohydro_1

# Metabolic_Enzyme_43_Signals:
None

# Metabolic_Enzyme_43_Transmembrane_Regions:
None

# Metabolic_Enzyme_43_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_43_EC_Link:
EC 3.5.4.3

# Metabolic_Enzyme_43_GenBank_ID_Protein:
4588080

# Metabolic_Enzyme_43_SwissProt_ID:
GUAD_HUMAN (Q9Y2T3)

# Metabolic_Enzyme_43_swissprot_Name:
Not Available

# Metabolic_Enzyme_43_Genecard_id:
GDA

# Metabolic_Enzyme_43_Geneatlas_id:
GDA

# Metabolic_Enzyme_43_hgnc_id:
HGNC:4212

# Metabolic_Enzyme_43_PDB_ID:
Not Available

# Metabolic_Enzyme_43_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_43_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_43_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_43_Gene_Sequence:
>1365 bp
ATGTGTGCCGCTCAGATGCCGCCCCTGGCGCACATCTTCCGAGGGACGTTCGTCCACTCC
ACCTGGACCTGCCCCATGGAGGTGCTGCGGGATCACCTCCTCGGCGTGAGCGACAGCGGC
AAAATAGTGTTTTTAGAAGAAGCATCTCAACAGGAAAAACTGGCCAAAGAATGGTGCTTC
AAGCCGTGTGAAATAAGAGAACTGAGCCACCATGAGTTCTTCATGCCTGGGCTGGTTGAT
ACACACATCCATGCCTCTCAGTATTCCTTTGCTGGAAGTAGCATAGACCTGCCACTCTTG
GAGTGGCTGACCAAGTACACATTTCCTGCAGAACACAGATTCCAGAACATCGACTTTGCA
GAAGAAGTATATACCAGAGTTGTCAGGAGAACACTAAAGAATGGAACAACCACAGCTTGT
TACTTTGCAACAATTCACACTGACTCATCTCTGCTCCTTGCCGACATTACAGATAAATTT
GGACAGCGGGCATTTGTGGGCAAAGTTTGCATGGATTTGAATGACACTTTTCCAGAATAC
AAGGAGACCACTGAGGAATCGATCAAGGAAACTGAGAGATTTGTGTCAGAAATGCTCCAA
AAGAACTATTCTAGAGTGAAGCCCATAGTGACACCACGTTTTTCCCTCTCCTGCTCTGAG
ACTTTGATGGGTGAACTGGGCAACATTGCTAAAACCCGTGATTTGCACATTCAGAGCCAT
ATAAGTGAAAATCGTGATGAAGTTGAAGCTGTGAAAAACTTATACCCCAGTTATAAAAAC
TACACATCTGTGTATGATAAAAACAATCTTTTGACAAATAAGACAGTGATGGCACACGGC
TGCTACCTCTCTGCAGAAGAACTGAACGTATTCCATGAACGAGGAGCATCCATCGCACAC
TGTCCCAATTCTAATTTATCGCTCAGCAGTGGATTTCTAAATGTGCTAGAAGTCCTGAAA
CATGAAGTCAAGATAGGGCTGGGTACAGACGTGGCTGGTGGCTATTCATATTCCATGCTT
GATGCAATCAGAAGAGCAGTGATGGTTTCCAATATCCTTTTAATTAATAAGGTAAATGAG
AAAAGCCTCACCCTCAAAGAAGTCTTCAGACTAGCTACTCTTGGAGGAAGCCAAGCCCTG
GGGCTGGATGGTGAGATTGGAAACTTTGAAGTGGGCAAGGAATTTGATGCCATCCTGATC
AACCCCAAAGCATCCGACTCTCCCATTGACCTGTTTTATGGGGACTTTTTTGGTGATATT
TCTGAGGCTGTTATCCAGAAGTTCCTCTATCTAGGAGATGATCGAAATATTGAAGAGGTT
TATGTGGGCGGAAAGCAGGTGGTTCCGTTTTCCAGCTCAGTGTAA

# Metabolic_Enzyme_43_GenBank_ID_Gene:
AF095286

# Metabolic_Enzyme_43_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_43_Locus:
9q21.13

# Metabolic_Enzyme_43_SNPs:
rs2208744; rs1123; rs4484759; rs7029873; rs7038786; rs6560259; rs11143168; rs10869149; rs4579592; rs10869150; rs4744663; rs11143170; rs7030578; rs10869148; rs10781089; rs4314712; rs7862279; rs10781082; rs7031258; rs11143193; rs10781090; rs10869151; rs4130867; rs7874671; rs10781077; rs7023949; rs10781079; rs7030035; rs10869130; rs7853683; rs11143155; rs7019328; rs13298434; rs10869142; rs10781084; rs17494144; rs10781086; rs4130866; rs13284274; rs12338453; rs11143162; rs7019060; rs11143145; rs7861301; rs10781078; rs10735614; rs4545160; rs11143141; rs10746905; rs17494172; rs7025700; rs10781088; rs17057544; rs7048306; rs4745175; rs10869135; rs4503167; rs11143175; rs11143143; rs7862343; rs17579467; rs7867133; rs4540461; rs4427235; rs7857832; rs17494835; rs17579544; rs10781085; rs10781083; rs11143198; rs6560255; rs11143176; rs7032697; rs7849653; rs10869137; rs10781087; rs10869136; rs17057536; rs11143200; rs11143169; rs2295902; rs12343189; rs11143192; rs10869140; rs12347198; rs10869134; rs4745176; rs7847604; rs12380886; rs10122641; rs11143190; rs10869133; rs11143181; rs7048302; rs7036326; rs7862991; rs7868844; rs7019189; rs13292413; rs11143187; rs4618766; rs7043791; rs7847150; rs17579286; rs4287006; rs10869138; rs7873543; rs7863465; rs12379746; rs11143178; rs11143139; rs7872576; rs4607679; rs11143164; rs7024598; rs7872253; rs12000573; rs11143136; rs10869131; rs12684664; rs11143160; rs7851247; rs12555257; rs7866644; rs10735615; rs11143150; rs10746906; rs11143188; rs10869141; rs11143183; rs11790220; rs4745178; rs12000375; rs11143174; rs7027274; rs10869139; rs11143180; rs7023029; rs12341210; rs7863894; rs5025470; rs17057532; rs13295564; rs10869143; rs17057547; rs7039714; rs17494333; rs11143186; rs7034285; rs7847039; rs12551201; rs10781080; rs4347048; rs13439903; rs7862293; rs10869145; rs7870435; rs17057543; rs7034622; rs3802506; rs35577632; rs7023990; rs13298009; rs12551494; rs12684798; rs7848617; rs10869132; rs11143144; rs11143199; rs7863016; rs7848485; rs7036479; rs7021424; rs11143134; rs4745174; rs7042164; rs41287399; rs41310055; rs3830994; rs35479709; rs34771500; rs34826830; rs11143146; rs34464792; rs34994180; rs12340785; rs7030138; rs36108105; rs11143182; rs10120863; rs34896961; rs12236224; rs35055310; rs11143171; rs11143158; rs35815597; rs11143157; rs35560375; rs13286309; rs35376951; rs11143151; rs10544644; rs13289128; rs11143197; rs34517745; rs11143177; rs13301296; rs13285773; rs34453023; rs35580322; rs36066152; rs12336009; rs34935659; rs10869146; rs11143149; rs35080524; rs7868258; rs35540892; rs34401093; rs28894678; rs7023048; rs4132371; rs34172929; rs34039840; rs35534385; rs36023536; rs35976245; rs41287397; rs11143153; rs5898250; rs28595862; rs10588583; rs35929343; rs7868716; rs11310535; rs7028888; rs13286407; rs11143156; rs11327039; rs35402815; rs9695829; rs35490187; rs34627726; rs36053013; rs34208420; rs11793595; rs41287395; rs35963716; rs34340676; rs11143172; rs11442621; rs35458479; rs11143189; rs34611287; rs12347850; rs11143154; rs34151593; rs34139960; rs34656645; rs35345284; rs13294538; rs12683149; rs35587485; rs36095417; rs35458310; rs35936702; rs36057739; rs13292781; rs6560258; rs13301429; rs35524358; rs34395320; rs34584186; rs13299869; rs34271428; rs11143191; rs41287393; rs34922880; rs35383444; rs34193771; rs11143165; rs7041441; rs35909348; rs11143152; rs35111628; rs11143147; rs34847117; rs11143196; rs34236424; rs12339560; rs9696551; rs34248273; rs34537821; rs11411689; rs10566596; rs34979271; rs35740394; rs12339476; rs11143159; rs12238209; rs13299660; rs7046424; rs13299525; rs12376597; rs11143140; rs11310536; rs5898251; rs10588582; rs11143173; rs35059295; rs11143185; rs34971662; rs28735208; rs13299684; rs11143142; rs11143148; rs35948411; rs9775806; rs11788934; rs34554102; rs11794239; rs13290949; rs36110660; rs7862462; rs13284666; rs12237065; rs11143137; rs11143163; rs34354742; rs34021514; rs13290586; rs36027299; rs13283169; rs35528537; rs7861241; rs10548640; rs11143167; rs35547082; rs10614254; rs28723000; rs5898249; rs35288910; rs10714440; rs41287401; rs10116055; rs1040921; rs10511997; rs10781076; rs10781091; rs10869154; rs11143130; rs11143202; rs11143203; rs11143204; rs11143205; rs11788021; rs12001463; rs13283346; rs13287540; rs17057466; rs34380537; rs4745173; rs6560260; rs7029217; rs7030520; rs7047289; rs7849775; rs7850131; rs7850499; rs7863053; rs7863804; rs7868366; rs7868495; rs7869950; rs969460

# Metabolic_Enzyme_43_General_References:
10075721; 10542258

# Metabolic_Enzyme_43_References:
Not Available

# Metabolic_Enzyme_44_ID:
5964

# Metabolic_Enzyme_44_Name:
Protein-glutamine gamma-glutamyltransferase 6

# Metabolic_Enzyme_44_Synonyms:
Transglutaminase-3-like; TGase-3-like; Transglutaminase Y

# Metabolic_Enzyme_44_Gene_Name:
TGM6

# Metabolic_Enzyme_44_Protein_Sequence:
>Proteinglutamine gammaglutamyltransferase 6
MAGIRVTKVDWQRSRNGAAHHTQEYPCPELVVRRGQSFSLTLELSRALDCEEILIFTMET
GPRASEALHTKAVFQTSELERGEGWTAAREAQMEKTLTVSLASPPSAVIGRYLLSIRLSS
HRKHSNRRLGEFVLLFNPWCAEDDVFLASEEERQEYVLSDSGIIFRGVEKHIRAQGWNYG
QFEEDILNICLSILDRSPGHQNNPATDVSCRHNPIYVTRVISAMVNSNNDRGVVQGQWQG
KYGGGTSPLHWRGSVAILQKWLKGRYKPVKYGQCWVFAGVLCTVLRCLGIATRVVSNFNS
AHDTDQNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARQDLGPSYNGWQVLDATPQ
EESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWHEDESRERVYSNTKKI
GRCISTKAVGSDSRVDITDLYKYPEGSRKERQVYSKAVNRLFGVEASGRRIWIRRAGGRC
LWRDDLLEPATKPSIAGKFKVLEPPMLGHDLRLALCLANLTSRAQRVRVNLSGATILYTR
KPVAEILHESHAVRLGPQEEKRIPITISYSKYKEDLTEDKKILLAAMCLVTKGEKLLVEK
DITLEDFITIKVLGPAMVGVAVTVEVTVVNPLIERVKDCALMVEGSGLLQEQLSIDVPTL
EPQERASVQFDITPSKSGPRQLQVDLVSPHFPDIKGFVIVHVATAK

# Metabolic_Enzyme_44_Number_of_Residues:
706

# Metabolic_Enzyme_44_Molecular_Weight:
79313

# Metabolic_Enzyme_44_Theoretical_pI:
7.26

# Metabolic_Enzyme_44_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  peptide cross-linking
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_44_General_Function:
Not Available

# Metabolic_Enzyme_44_Specific_Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins

# Metabolic_Enzyme_44_Pathway:
Not Available

# Metabolic_Enzyme_44_Reaction:
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3

# Metabolic_Enzyme_44_Pfam_Domain_Function:
PF00927:Transglut_C;
PF01841:Transglut_core;
PF00868:Transglut_N

# Metabolic_Enzyme_44_Signals:
None

# Metabolic_Enzyme_44_Transmembrane_Regions:
None

# Metabolic_Enzyme_44_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_44_EC_Link:
EC 2.3.2.13

# Metabolic_Enzyme_44_GenBank_ID_Protein:
33331030

# Metabolic_Enzyme_44_SwissProt_ID:
TGM3L_HUMAN (O95932)

# Metabolic_Enzyme_44_swissprot_Name:
Not Available

# Metabolic_Enzyme_44_Genecard_id:
TGM6

# Metabolic_Enzyme_44_Geneatlas_id:
TGM6

# Metabolic_Enzyme_44_hgnc_id:
HGNC:16255

# Metabolic_Enzyme_44_PDB_ID:
Not Available

# Metabolic_Enzyme_44_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_44_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_44_Subcellular_Location:
Not Available

# Metabolic_Enzyme_44_Gene_Sequence:
>2121 bp
ATGGCAGGGATCAGAGTCACCAAGGTGGACTGGCAGCGGTCGAGGAATGGCGCTGCCCAC
CACACCCAGGAGTACCCCTGCCCTGAGCTGGTGGTTCGCAGGGGCCAGTCGTTCAGCCTC
ACGCTGGAGCTGAGCAGAGCCCTGGACTGTGAGGAGATCCTCATCTTCACGGTGGAGACA
GGACCCCGGGCTTCTGAGGCCCTCCACACCAAAGCTGTGTTCCAGACATCGGAGCTGGAG
CGGGGTGAGGGCTGGACAGCAGCAAGGGAGGCTCAGATGGAGAAAACTCTGACCGTCAGT
CTCGCCAGCCCTCCCAGTGCTGTCATTGGCCGCTACCTGCTGAGCATCAGGCTTTCCTCT
CACCGCAAACACAGCAACCGGAGGCTGGGCGAGTTTGTTCTCCTTTTCAACCCATGGTGT
GCAGAGGACGATGTGTTTCTGGCCTCAGAGGAGGAGAGACAGGAGTACGTGCTCAGCGAC
AGCGGCATCATCTTCCGAGGCGTGGAGAAGCACATACGAGCCCAGGGCTGGAACTACGGG
CAGTTTGAGGAGGACATCCTGAACATCTGCCTCTCCATCCTGGATCGAAGCCCCGGTCAC
CAAAACAACCCAGCCACCGACGTGTCCTGCCGCCACAACCCCATCTACGTCACCAGGGTC
ATCAGTGCCATGGTGAACAGCAACAACGACCGAGGTGTGGTGCAAGGACAGTGGCAGGGC
AAGTACGGCGGCGGCACCAGCCCGCTGCACTGGCGCGGCAGCGTGGCCATTCTGCAGAAG
TGGCTCAAGGGCAGGTACAAGCCAGTCAAGTACGGCCAGTGCTGGGTCTTCGCCGGAGTC
CTGTGCACAGTCCTCAGGTGCTTGGGGATAGCCACACGGGTCGTGTCCAACTTCAACTCA
GCCCACGACACAGACCAGAACCTGAGTGTGGACAAATACGTGGACTCCTTCGGGCGGACC
CTGGAGGACCTGACAGAAGACAGCATGTGGAATTTCCATGTCTGGAATGAGAGCTGGTTT
GCCCGGCAGGACCTAGGCCCCTCTTACAATGGCTGGCAGGTTCTGGATGCCACCCCCCAG
GAGGAGAGTGAAGGTGTGTTCCGGTGCGGCCCAGCCTCAGTCACCGCCATCCGCGAGGGT
GATGTGCACCTGGCTCACGATGGCCCCTTCGTGTTTGCGGAGGTCAACGCCGACTACATC
ACCTGGCTGTGGCACGAGGATGAGAGCCGGGAGCGTGTATACTCAAACACGAAGAAGATT
GGGAGATGCATCAGCACCAAGGCGGTGGGCAGTGACTCCCGCGTGGACATCACTGACCTC
TACAAGTATCCGGAAGGGTCCCGGAAAGAGAGGCAGGTGTACAGCAAGGCGGTGAACAGG
CTGTTCGGCGTGGAAGCCTCTGGAAGGAGAATCTGGATCCGCAGGGCTGGGGGTCGCTGT
CTCTGGCGTGACGACCTCCTGGAGCCTGCCACCAAGCCCAGCATCGCTGGCAAGTTCAAG
GTGCTAGAGCCTCCCATGCTGGGCCACGACCTGAGACTGGCCCTGTGCTTGGCCAACCTC
ACCTCCCGGGCCCAGCGGGTGAGGGTCAACCTGAGCGGTGCCACCATCCTCTATACCCGC
AAGCCAGTGGCAGAGATCCTGCATGAATCCCACGCCGTGAGGCTGGGGCCGCAAGAAGAG
AAGAGAATCCCAATTACAATATCTTACTCTAAGTATAAAGAAGACCTGACAGAGGACAAG
AAGATCCTGTTGGCTGCCATGTGCCTTGTCACCAAAGGAGAGAAGCTTCTGGTGGAGAAG
GACATTACTCTAGAGGACTTCATCACCATCAAGGTTCTGGGCCCAGCCATGGTGGGAGTG
GCAGTTACAGTGGAAGTGACAGTAGTCAACCCCCTCATAGAGAGAGTGAAGGACTGTGCG
CTGATGGTGGAGGGCAGCGGCCTTCTCCAGGAACAGCTCAGCATCGACGTGCCTACCCTG
GAGCCTCAGGAGAGGGCCTCAGTCCAGTTTGACATCACCCCCTCCAAAAGTGGCCCAAGG
CAGCTGCAGGTGGACCTTGTAAGCCCTCACTTCCCGGACATCAAGGGCTTTGTGATCGTC
CATGTGGCCACTGCCAAGTGA

# Metabolic_Enzyme_44_GenBank_ID_Gene:
AF540969

# Metabolic_Enzyme_44_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_44_Locus:
20p13

# Metabolic_Enzyme_44_SNPs:
rs2076405; rs6114033; rs2295077; rs16984872; rs2076652; rs2076650; rs7263876; rs3865538; rs6048846; rs6048642; rs2422767; rs2422771; rs8124987; rs1474678; rs2422770; rs2422761; rs2422768; rs3865537; rs8115012; rs13045470; rs2076649; rs2422764; rs6137978; rs6113988; rs2422773; rs4428078; rs6036442; rs6048754; rs8119282; rs6137955; rs2422765; rs2422758; rs2422763; rs6036398; rs6083123; rs2422766; rs6048869; rs6036342; rs6132633; rs2235609; rs2422762; rs2076653; rs1004269; rs6106641; rs2092632; rs6132596; rs2076654; rs11700175; rs2076404; rs6113950; rs6048587; rs2325847; rs4461332; rs2422753; rs6048880; rs6114060; rs6137994; rs6114061; rs742823; rs6132595; rs6137946; rs4404344; rs6036404; rs13037184; rs2092633; rs6036430; rs13040968; rs10485600; rs3865536; rs6048871; rs2422754; rs1967678; rs2422772; rs6036350; rs4441546; rs6048788; rs6106621; rs2179828; rs2092631; rs6114150; rs16984767; rs4053458; rs2325848; rs6036390; rs6106668; rs6083041; rs13045070; rs6083018; rs8115487; rs16984996; rs6106653; rs6113984; rs6137972; rs8126371; rs6048613; rs2422760; rs6114121; rs7269048; rs2422756; rs2422774; rs6114027; rs6132618; rs6114062; rs6137891; rs6137902; rs2223859; rs6137911; rs6048862; rs6076037; rs6137956; rs6113939; rs2422757; rs6048878; rs6106640; rs6048570; rs2076648; rs2092379; rs2422769; rs6048684; rs2875760; rs6137965; rs6132619; rs11696420; rs13433241; rs6048868; rs6137904; rs6048768; rs11696423; rs4053457; rs6137912; rs6114075; rs11700354; rs6106604; rs4349401; rs6048796; rs6048752; rs6137852; rs6106683; rs6048870; rs2422755; rs8123084; rs6083054; rs6106625; rs6048563; rs6132624; rs6113955; rs2422759; rs7271300; rs9680019; rs6083001; rs9680025; rs6113932; rs2422752; rs12106280; rs11478666; rs12106116; rs13044306; rs11477545; rs11474621; rs10548828; rs11477942; rs2103758; rs34159462; rs6036327; rs34934730; rs6114052; rs6132635; rs10599806; rs11481317; rs6083144; rs7266902; rs6114056; rs35094578; rs3050737; rs34909737; rs6036331; rs28605071; rs8113916; rs35498299; rs6106620; rs35135829; rs13037449; rs34445977; rs6114057; rs6114162; rs9679998; rs6137862; rs6076077; rs11470465; rs6114076; rs34245773; rs7361683; rs6114114; rs13039571; rs34249296; rs2103759; rs6048567; rs11483293; rs6083019; rs6076054; rs6048758; rs35319898; rs11480817; rs7361473; rs11426342; rs6036427; rs28603365; rs34341795; rs1004268; rs35294593; rs6048861; rs35121359; rs6137888; rs6083143; rs17222895; rs35384370; rs33948150; rs12106237; rs6036314; rs34902644; rs35864458; rs11482107; rs6036389; rs36106878; rs6106671; rs34418464; rs6048902; rs33998426; rs34573803; rs11482900; rs6083068; rs34170813; rs35843804; rs7360200; rs34384547; rs6132637; rs10626077; rs6132638; rs7264522; rs11442124; rs33919468; rs34097585; rs6036329; rs11469865; rs10626299; rs6137868; rs34190162; rs3050743; rs2325846; rs6137879; rs6048565; rs34261789; rs35409492; rs6036467; rs34127349; rs33957203; rs34073977; rs36028144; rs34105580; rs35732086; rs6114081; rs6048881; rs36055977; rs6048675; rs6036312; rs34084659; rs11469794; rs3050735; rs6036431; rs4632428; rs12106117; rs13045947; rs6083034; rs34972666; rs6114002; rs41301752; rs6083028; rs3050731; rs34739156; rs34572886; rs36209483; rs34262420; rs34077962; rs1003488; rs13037404; rs11468734; rs6113940; rs4473460; rs11468806; rs33943065; rs35260408; rs6048865; rs6138002; rs6048588; rs34074229; rs11481911; rs9789801; rs34941654; rs11482757; rs36006705; rs9917440; rs28429255; rs41301754; rs34282039; rs28475778; rs34636509; rs13041071; rs35174834; rs10677058; rs6113934; rs28505454; rs3925862; rs1008405; rs1040485; rs1040486; rs1040487; rs12624537; rs13043849; rs13045386; rs1474680; rs16984515; rs17315896; rs2143246; rs2325850; rs2422733; rs2422734; rs2422735; rs2422739; rs2422740; rs2422741; rs2422742; rs2422751; rs4813474; rs4813475; rs4813507; rs4815171; rs4815227; rs6036285; rs6036286; rs6036288; rs6036289; rs6036290; rs6048503; rs6048507; rs6048508; rs6048509; rs6048510; rs6048521; rs6048528; rs6048961; rs6048966; rs6048968; rs6048970; rs6076015; rs6082968; rs6082976; rs6082996; rs6083228; rs6114219; rs6114223; rs6132559; rs6132649; rs6138035; rs6138041; rs726600; rs7274316; rs763996; rs8118007; rs956328; rs991187; rs991189

# Metabolic_Enzyme_44_General_References:
11780052

# Metabolic_Enzyme_44_References:
Not Available

# Metabolic_Enzyme_45_ID:
5965

# Metabolic_Enzyme_45_Name:
Glutaminyl-peptide cyclotransferase precursor

# Metabolic_Enzyme_45_Synonyms:
QC; Glutaminyl-tRNA cyclotransferase; Glutaminyl cyclase

# Metabolic_Enzyme_45_Gene_Name:
QPCT

# Metabolic_Enzyme_45_Protein_Sequence:
>Glutaminylpeptide cyclotransferase precursor
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L

# Metabolic_Enzyme_45_Number_of_Residues:
361

# Metabolic_Enzyme_45_Molecular_Weight:
40877

# Metabolic_Enzyme_45_Theoretical_pI:
6.60

# Metabolic_Enzyme_45_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_45_General_Function:
Not Available

# Metabolic_Enzyme_45_Specific_Function:
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue

# Metabolic_Enzyme_45_Pathway:
Not Available

# Metabolic_Enzyme_45_Reaction:
L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3

# Metabolic_Enzyme_45_Pfam_Domain_Function:
PF04389:Peptidase_M28

# Metabolic_Enzyme_45_Signals:
1-28

# Metabolic_Enzyme_45_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_45_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_45_EC_Link:
EC 2.3.2.5

# Metabolic_Enzyme_45_GenBank_ID_Protein:
296949

# Metabolic_Enzyme_45_SwissProt_ID:
QPCT_HUMAN (Q16769)

# Metabolic_Enzyme_45_swissprot_Name:
Not Available

# Metabolic_Enzyme_45_Genecard_id:
QPCT

# Metabolic_Enzyme_45_Geneatlas_id:
QPCT

# Metabolic_Enzyme_45_hgnc_id:
HGNC:9753

# Metabolic_Enzyme_45_PDB_ID:
Not Available

# Metabolic_Enzyme_45_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_45_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_45_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_45_Gene_Sequence:
>1086 bp
ATGGCAGGCGGAAGACACCGGCGCGTCGTGGGCACCCTCCACCTGCTGCTGCTGGTGGCC
GCCCTGCCCTGGGCATCCAGGGGGGTCAGTCCGAGTGCCTCAGCCTGGCCAGAGGAGAAG
AATTACCACCAGCCAGCCATTTTGAATTCATCGGCTCTTCGGCAAATTGCAGAAGGCACC
AGTATCTCTGAAATGTGGCAAAATGACTTACAGCCATTGCTGATAGAGCGATACCCGGGA
TCCCCTGGAAGCTATGCTGCTCGTCAGCACATCATGCAGCGAATTCAGAGGCTTCAGGCT
GACTGGGTCTTGGAAATAGACACCTTCTTGAGTCAGACACCCTATGGGTACCGGTCTTTC
TCAAATATCATCAGCACCCTCAATCCCACTGCTAAACGACATTTGGTCCTCGCCTGCCAC
TATGACTCCAAGTATTTTTCCCACTGGAACAACAGAGTGTTTGTAGGAGCCACTGATTCA
GCCGTGCCATGTGCAATGATGTTGGAACTTGCTCGTGCCTTAGACAAGAAACTCCTTTCC
TTAAAGACTGTTTCAGACTCCAAGCCAGATTTGTCACTCCAGCTGATCTTCTTTGATGGT
GAAGAGGCTTTTCTTCACTGGTCTCCTCAAGATTCTCTCTATGGGTCTCGACACTTAGCT
GCAAAGATGGCATCGACCCCGCACCCACCTGGAGCGAGAGGCACCAGCCAACTGCATGGC
ATGGATTTATTGGTCTTATTGGATTTGATTGGAGCTCCAAACCCAACGTTTCCCAATTTT
TTTCCAAACTCAGCCAGGTGGTTCGAAAGACTTCAAGCAATTGAACATGAACTTCATGAA
TTGGGTTTGCTCAAGGATCACTCTTTGGAGGGGCGGTATTTCCAGAATTACAGTTATGGA
GGTGTGATTCAGGATGACCATATTCCATTTTTAAGAAGAGGTGTTCCAGTTCTGCATCTG
ATACCGTCTCCTTTCCCTGAAGTCTGGCACACCATGGATGACAATGAAGAAAATTTGGAT
GAATCAACCATTGACAATCTAAACAAAATCCTACAAGTCTTTGTGTTGGAATATCTTCAT
TTGTAA

# Metabolic_Enzyme_45_GenBank_ID_Gene:
X71125

# Metabolic_Enzyme_45_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_45_Locus:
2p22.2

# Metabolic_Enzyme_45_SNPs:
rs2255991; rs2302652; rs6708310; rs10724; rs4670697; rs2373001; rs2058718; rs2302651; rs6730342; rs4670196; rs7603787; rs3815555; rs4384764; rs3770751; rs1468816; rs10198567; rs3770749; rs3770747; rs2270331; rs3770744; rs2287094; rs2058719; rs2373000; rs3770752; rs3770748; rs5017961; rs3770743; rs7564929; rs3770745; rs11897920; rs7606760; rs3770755; rs17020575; rs10196818; rs11897397; rs12467820; rs12472984; rs2888464; rs10490448; rs3821141; rs4444500; rs3770742; rs10865124; rs3770754; rs11689966; rs7576265; rs12468307; rs17020573; rs11886606; rs7582749; rs3770753; rs7600995; rs7606958; rs2372999; rs3821142; rs11890834; rs11903018; rs11891757; rs3770756; rs6756313; rs6544068; rs6544071; rs6753973; rs3755192; rs10170761; rs6544069; rs6544070; rs28384455; rs7601156; rs11555863; rs4670696; rs34476437; rs35184928; rs11555864; rs11555868; rs11555866; rs11555867; rs10683912; rs6706962; rs5830468; rs5830472; rs34891857; rs34156721; rs28609229; rs34908408; rs5830470; rs6721456; rs4670692; rs5017958; rs34281820; rs11124580; rs11402827; rs35157042; rs34534488; rs7596533; rs35426724; rs5830469; rs35661618; rs34300100; rs33911187; rs2372998; rs13015398; rs6708524; rs5017957; rs13404955; rs4479412; rs34463193; rs10203892; rs6722596; rs35276025; rs5830471; rs10179447; rs5017959; rs34773159; rs4670693; rs6708822; rs33960638; rs41280633; rs7603448; rs13015242; rs35921229; rs3770750; rs5017960; rs10558124; rs34763736; rs36087946; rs11902200; rs35537217; rs28590119; rs34679162; rs34524888; rs34231434; rs10598967; rs11124581; rs10185381; rs5830467; rs7584351; rs10189564; rs4479411; rs35576045; rs7587371; rs6732590; rs6761908; rs3755191; rs10084460; rs1024815; rs1024816; rs10490446; rs10490447; rs1105965; rs1105966; rs11886889; rs13030789; rs13417425; rs17020604; rs17020611; rs17020620; rs17020624; rs17020628; rs2041841; rs4233922; rs4425058; rs4670197; rs7559558; rs7570974; rs7585826; rs7593887; rs7593932; rs888096; rs952711; rs952712

# Metabolic_Enzyme_45_General_References:
7999256

# Metabolic_Enzyme_45_References:
Not Available

# Metabolic_Enzyme_46_ID:
5966

# Metabolic_Enzyme_46_Name:
Protein-glutamine gamma-glutamyltransferase Z

# Metabolic_Enzyme_46_Synonyms:
TGase Z; TGZ; TG(Z; Transglutaminase 7

# Metabolic_Enzyme_46_Gene_Name:
TGM7

# Metabolic_Enzyme_46_Protein_Sequence:
>Proteinglutamine gammaglutamyltransferase 
ZMDQVATLRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSFSRPFQSQNDHIT
FVAETGPKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIGHYTLK
IEISQGQGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITS
WPWNYGQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVL
QGNWGEDYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRV
VSNFRSAHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQV
LDPTPQQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQEILA
HNTSSIGKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKASRKMLGPQRASLPFLDL
LESGGLRDQPAQLQLHLARIPEWGQDLQLLLRIQRVPDSTHPRGPIGLVVRFCAQALLHG
GGTQKPFWRHTVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVSGIAEVEETGRSMLV
LKDICLEPPHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLEGSGLINGQIAKDL
GTLVAGHTLQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFVTVAGAP

# Metabolic_Enzyme_46_Number_of_Residues:
710

# Metabolic_Enzyme_46_Molecular_Weight:
79942

# Metabolic_Enzyme_46_Theoretical_pI:
7.00

# Metabolic_Enzyme_46_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  peptide cross-linking
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_46_General_Function:
Not Available

# Metabolic_Enzyme_46_Specific_Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins

# Metabolic_Enzyme_46_Pathway:
Not Available

# Metabolic_Enzyme_46_Reaction:
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3

# Metabolic_Enzyme_46_Pfam_Domain_Function:
PF00927:Transglut_C;
PF01841:Transglut_core;
PF00868:Transglut_N

# Metabolic_Enzyme_46_Signals:
None

# Metabolic_Enzyme_46_Transmembrane_Regions:
None

# Metabolic_Enzyme_46_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_46_EC_Link:
EC 2.3.2.13

# Metabolic_Enzyme_46_GenBank_ID_Protein:
15425755

# Metabolic_Enzyme_46_SwissProt_ID:
TGM7_HUMAN (Q96PF1)

# Metabolic_Enzyme_46_swissprot_Name:
Not Available

# Metabolic_Enzyme_46_Genecard_id:
TGM7

# Metabolic_Enzyme_46_Geneatlas_id:
TGM7

# Metabolic_Enzyme_46_hgnc_id:
HGNC:30790

# Metabolic_Enzyme_46_PDB_ID:
Not Available

# Metabolic_Enzyme_46_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_46_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_46_Subcellular_Location:
Not Available

# Metabolic_Enzyme_46_Gene_Sequence:
>2133 bp
ATGGATCAGGTGGCAACCTTGCGGCTTGAGTCTGTCGACCTGCAGAGCTCCAGGAACAAC
AAGGAGCACCACACGCAGGAGATGGGCGTCAAGCGGCTCACTGTGCGCCGCGGCCAGCCC
TTCTACCTCCGGCTGAGCTTCAGCCGACCCTTCCAGTCCCAGAACGACCACATCACCTTT
GTGGCTGAGACCGGACCCAAGCCGTCAGAGCTGCTGGGGACCCGAGCCACATTCTTCCTC
ACCCGGGTCCAGCCCGGGAATGTCTGGAGCGCTTCTGATTTCACCATTGACTCCAACTCT
CTCCAAGTTTCCCTTTTCACACCAGCCAATGCAGTTATTGGCCATTACACTCTGAAAATA
GAGATCTCTCAGGGCCAAGGTCACAGTGTGACTTACCCGCTGGGAACTTTCATCCTACTT
TTTAACCCTTGGAGTCCAGAGGACGACGTCTACCTGCCAAGTGAAATACTGCTGCAGGAG
TATATCATGCGAGATTATGGCTTTGTTTACAAGGGTCATGAAAGATTCATCACCTCCTGG
CCCTGGAACTACGGGCAGTTTGAAGAGGACATCATAGACATCTGCTTTGAGATCCTGAAC
AAGAGCCTGTATCACTTAAAGAACCCGGCCAAAGACTGTTCCCAGCGGAACGACGTGGTG
TATGTGTGCAGGGTGGTGAGTGCCATGATCAACAGCAACGATGACAATGGCGTGCTGCAG
GGGAACTGGGGCGAGGACTACTCCAAAGGGGTCAGTCCTCTGGAGTGGAAGGGCAGTGTG
GCCATCCTACAGCAGTGGTCAGCCAGGGGCGGGCAGCCTGTGAAGTACGGACAGTGCTGG
GTCTTCGCCTCTGTTATGTGCACCGTAATGAGATGCTTAGGTGTTCCAACCCGTGTTGTT
TCCAATTTCCGTTCCGCGCACAACGTGGATAGGAACTTGACCATCGATACGTACTATGAC
CGAAATGCCGAGATGCTGTCAACTCAGAAACGAGACAAAATATGGAACTTCCACGTCTGG
AATGAGTGCTGGATGATCCGGAAAGATCTCCCACCAGGATACAACGGGTGGCAGGTTCTG
GACCCCACTCCCCAGCAGACCAGCAGTGGGCTGTTCTGCTGTGGCCCTGCCTCTGTGAAG
GCCATCAGGGAAGGGGATGTCCACCTGGCCTATGACACCCCTTTTGTGTATGCCGAGGTG
AACGCCGATGAAGTCATTTGGCTCCTTGGGGATGGCCAGGCCCAGGAAATCCTGGCCCAC
AACACCAGTTCCATCGGGAAGGAGATCAGCACTAAGATGGTGGGGTCAGACCAGCGCCAG
AGCATCACCAGCTCCTACAAGTACCCAGAAGGATCCCCTGAGGAGAGAGCTGTCTTCATG
AAGGCTTCTCGGAAAATGCTGGGCCCCCAAAGAGCTTCTTTGCCCTTCCTGGATCTCCTG
GAGTCTGGGGGTCTTAGGGATCAGCCAGCGCAGCTGCAGCTTCACCTGGCCAGGATACCC
GAGTGGGGCCAGGACCTGCAGCTGCTGCTGCGTATCCAGAGGGTGCCAGACAGCACCCAC
CCTCGGGGGCCCATCGGACTGGTGGTGCGCTTCTGTGCACAGGCCCTGCTGCATGGGGGT
GGTACCCAGAAGCCCTTCTGGAGGCACACAGTGCGGATGAACCTGGACTTTGGGAAGGAG
ACACAGTGGCCGCTCCTCCTGCCCTACAGCAATTACAGAAACAAGCTAACGGACGAAAAG
CTCATCCGCGTGTCTGGCATCGCGGAGGTTGAAGAGACAGGGAGGTCCATGCTGGTCCTA
AAAGATATCTGTCTGGAGCCTCCCCACTTGTCTATTGAGGTGTCTGAGAGGGCTGAGGTG
GGCAAGGCGCTGAGAGTCCATGTCACCCTCACCAACACCTTAATGGTGGCTCTGAGCAGC
TGCACGATGGTGCTGGAAGGAAGCGGCCTCATCAATGGGCAGATAGCAAAGGACCTTGGG
ACTCTGGTGGCCGGACACACCCTCCAAATTCAACTGGACCTCTACCCGACCAAAGCTGGA
CCCCGCCAGCTCCAGGTTCTCATCAGCAGCAACGAGGTCAAGGAGATCAAAGGCTACAAG
GACATATTCGTCACTGTGGCTGGGGCTCCCTGA

# Metabolic_Enzyme_46_GenBank_ID_Gene:
AF363393

# Metabolic_Enzyme_46_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_46_Locus:
15q15.2

# Metabolic_Enzyme_46_SNPs:
rs567357; rs513970; rs35228126; rs6493080; rs1108462; rs580469; rs825734; rs518261; rs489509; rs532672; rs556851; rs825740; rs825739; rs17779494; rs505276; rs485148; rs575304; rs825732; rs2412777; rs546722; rs491648; rs523737; rs518234; rs538238; rs498227; rs1896173; rs530683; rs491800; rs825733; rs8033666; rs12591919; rs8036632; rs12148735; rs478104; rs473554; rs1095389; rs4923962; rs7496049; rs558010; rs519926; rs35879868; rs35079211; rs34351037; rs7168979; rs34113528; rs519923; rs11335371; rs10697502; rs10654403; rs28448560; rs7171080; rs36122718; rs35603531; rs34502725; rs28673179; rs12909323; rs28496779; rs35571834; rs35782967; rs7171875; rs34776386; rs35891068; rs28446815; rs7169610; rs10668842; rs34487818; rs35430153; rs35119966; rs35387654; rs1095387; rs4923963; rs12901317; rs35005663; rs28641964; rs28525078; rs28594657; rs28600080; rs3038034; rs10661291; rs11637381; rs35124769; rs35863449; rs34647408; rs4923961; rs12185126; rs7173031; rs7180111; rs34927191; rs35220314; rs35393230; rs12915538; rs2277527; rs2577057; rs28377745; rs3759788; rs471122; rs473016; rs491804; rs492743; rs493444; rs505249; rs524527; rs526450; rs531910; rs573774; rs576557; rs748404

# Metabolic_Enzyme_46_General_References:
11390390

# Metabolic_Enzyme_46_References:
Not Available

# Metabolic_Enzyme_47_ID:
5967

# Metabolic_Enzyme_47_Name:
Glutamate dehydrogenase 1, mitochondrial precursor

# Metabolic_Enzyme_47_Synonyms:
GDH

# Metabolic_Enzyme_47_Gene_Name:
GLUD1

# Metabolic_Enzyme_47_Protein_Sequence:
>Glutamate dehydrogenase 1, mitochondrial precursor
MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPGLALAARRHYSEAVADR
EDDPNFFKMVEGFFDRGASIVEDKLVEDLRTRESEEQKRNRVRGILRIIKPCNHVLSLSF
PIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFG
GAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTY
ASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFG
DKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILG
FPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLER
NIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGK
HGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYV
NAIEKVFKVYNEAGVTFT

# Metabolic_Enzyme_47_Number_of_Residues:
558

# Metabolic_Enzyme_47_Molecular_Weight:
61399

# Metabolic_Enzyme_47_Theoretical_pI:
7.91

# Metabolic_Enzyme_47_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_47_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_47_Specific_Function:
May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate

# Metabolic_Enzyme_47_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00251  Glutamate metabolism;
 map00330  Arginine and proline metabolism;
 map00471  D-Glutamine and D-glutamate metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_47_Reaction:
L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + ammonia + NAD(P)H + H+

# Metabolic_Enzyme_47_Pfam_Domain_Function:
PF00208:ELFV_dehydrog;
PF02812:ELFV_dehydrog_N

# Metabolic_Enzyme_47_Signals:
1-20

# Metabolic_Enzyme_47_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_47_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_47_EC_Link:
EC 1.4.1.3

# Metabolic_Enzyme_47_GenBank_ID_Protein:
31707

# Metabolic_Enzyme_47_SwissProt_ID:
DHE3_HUMAN (P00367)

# Metabolic_Enzyme_47_swissprot_Name:
Not Available

# Metabolic_Enzyme_47_Genecard_id:
GLUD1

# Metabolic_Enzyme_47_Geneatlas_id:
GLUD1

# Metabolic_Enzyme_47_hgnc_id:
HGNC:4335

# Metabolic_Enzyme_47_PDB_ID:
1L1F

# Metabolic_Enzyme_47_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_47_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_47_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_47_Gene_Sequence:
>1677 bp
ATGTACCGCTACCTGGGCGAAGCGCTGTTGCTGTCCCGGGCCGGGCCCGCTGCCCTGGGC
TCGGCGTCCGCCGACTCGGCCGCGTTGCTGGGCTGGGCCCGGGGACAGCCCGCCGCCGCC
CCGCAGCCGGGGCTGGCATTGGCCGCCCGGCGCCACTACAGCGAGGCGGTGGCCGACCGC
GAGGACGACCCCAACTTCTTCAAGATGGTGGAGGGCTTCTTCGATCGCGGCGCCAGCATC
GTGGAGGACAAGCTGGTGGAGGACCTGAGGACCCGGGAGAGCGAGGAGCAGAAGCGGAAC
CGGGTGCGCGGCATCCTGCGGATCATCAAGCCCTGCAACCATGTGCTGAGTCTCTCCTTC
CCCATCCGGCGCGACGACGGCTCCTGGGAGGTCATCGAAGGCTACCGGGCCCAGCACAGC
CAGCACCGCACGCCCTGCAAGGGAGGTATCCGTTACAGCACTGATGTGAGTGTAGATGAA
GTAAAAGCTTTGGCTTCTCTGATGACATACAAGTGTGCAGTGGTTGATGTGCCGTTTGGG
GGTGCTAAAGCTGGTGTTAAGATCAATCCCAAGAACTATACTGATAATGAATTGGAAAAG
ATCACAAGGAGGTTCACCATGGAGCTAGCAAAAAAGGGCTTTATTGGTCCTGGCATTGAT
GTGCCTGCTCCAGACATGAGCACAGGTGAGCGGGAGATGTCCTGGATCGCTGATACCTAT
GCCAGCACCATAGGGCACTATGATATTAATGCACACGCCTGTGTTACTGGTAAACCCATC
AGCCAAGGGGGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGGGATT
GAAAATTTCATCAATGAAGCTTCTTACATGAGCATTTTAGGAATGACACCAGGGTTTGGA
GATAAAACATTTGTTGTTCAGGGATTTGGTAATGTGGGCCTACACTCTATGAGATATTTA
CATCGTTTTGGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAATCCA
GATGGTATTGACCCAAAGGAACTGGAAGACTTCAAATTGCAACATGGGTCCATTCTGGGC
TTCCCCAAGGCAAAGCCCTATGAAGGAAGCATCTTGGAGGCCGACTGTGACATACTGATC
CCAGCTGCCAGTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAAGATC
ATTGCTGAAGGTGCCAATGGGCCAACAACTCCAGAAGCTGACAAGATCTTCCTGGAGAGA
AACATTATGGTTATTCCAGATCTCTACTTGAATGCTGGAGGAGTGACAGTATCTTACTTT
GAGTGGCTGAAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGAAAGG
GATTCTAACTACCACTTGCTCATGTCTGTTCAAGAGAGTTTAGAAAGAAAATTTGGAAAG
CATGGTGGAACTATTCCCATTGTACCCACGGCAGAGTTCCAAGACAGGATATCGGGTGCA
TCTGAGAAAGACATCGTGCACTCTGGCTTGGCATACACAATGGAGCGTTCTGCCAGGCAA
ATTATGCGCACAGCCATGAAGTATAACCTGGGATTGGACCTGAGAACAGCTGCCTATGTT
AATGCCATTGAGAAAGTCTTCAAAGTGTACAATGAAGCTGGTGTGACCTTCACATAG

# Metabolic_Enzyme_47_GenBank_ID_Gene:
X07674

# Metabolic_Enzyme_47_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_47_Locus:
10q23.3

# Metabolic_Enzyme_47_SNPs:
rs2181522; rs1923939; rs2296061; rs7083075; rs6586053; rs9420432; rs2296063; rs7903935; rs7069764; rs12416157; rs7098123; rs4934292; rs7068848; rs9421580; rs7077790; rs9421571; rs10887689; rs17107329; rs9421579; rs9420431; rs4933427; rs9421573; rs7072835; rs2146720; rs7080134; rs4934294; rs4460731; rs12414004; rs12778953; rs7076542; rs9421574; rs17107324; rs17343630; rs4275529; rs10887688; rs7090928; rs11202313; rs4460730; rs6586054; rs1923933; rs7076857; rs11202328; rs7895873; rs9420434; rs4491135; rs4934295; rs12257719; rs10887690; rs7085236; rs11202311; rs17343324; rs745224; rs1050340; rs1050359; rs1050306; rs1050319; rs11548293; rs3190657; rs12980; rs1803640; rs9420433; rs11202315; rs3204151; rs33966755; rs11453443; rs11202318; rs7096113; rs9421575; rs9421578; rs34096944; rs34237834; rs41448647; rs34610047; rs4933426; rs11306284; rs7903094; rs11202326; rs34760005; rs4370842; rs9732169; rs12781507; rs35027759; rs11202314; rs5786757; rs12761256; rs28590183; rs3204153; rs1923935; rs1923934; rs11202321; rs7075538; rs11202316; rs5786756; rs7478413; rs7911871; rs4934293; rs10544932; rs28581586; rs11202327; rs35275424; rs9421577; rs11202320; rs12416344; rs34141032; rs36124172; rs7067639; rs10565916; rs11202323; rs12763774; rs7069518; rs11202319; rs7083943; rs11202324; rs9421576; rs1923937; rs9421581; rs4244974; rs35186250; rs12256112; rs7089351; rs34165463; rs9420430; rs11272037; rs1923936; rs11202322; rs28621802; rs12778122; rs4934296; rs12256919; rs9651489; rs3204150; rs36079084; rs10909633; rs12266578; rs10655872; rs12763347; rs10535860; rs11202317; rs7096107; rs11345875; rs7923785; rs35002136; rs34156521; rs11202325; rs35811908; rs11431413; rs1923938; rs35075180; rs11428350; rs34933272; rs5786753; rs9421569; rs9420429; rs35924180; rs34324523; rs34307641; rs34369587; rs1050156; rs11202310; rs12251095; rs2296062; rs4430417

# Metabolic_Enzyme_47_General_References:
3426581; 3377777; 3399399; 3368458; 8486350; 429360; 1286669; 3585334; 8314555; 11254391; 11903050; 12054821; 12653548; 10338089; 9571255; 10636977; 11214910; 11297618

# Metabolic_Enzyme_47_References:
Not Available

# Metabolic_Enzyme_48_ID:
5968

# Metabolic_Enzyme_48_Name:
Glyceraldehyde-3-phosphate dehydrogenase

# Metabolic_Enzyme_48_Synonyms:
GAPDH

# Metabolic_Enzyme_48_Gene_Name:
GAPDH

# Metabolic_Enzyme_48_Protein_Sequence:
>Glyceraldehyde3phosphate dehydrogenase
MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTV
KAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVI
ISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHA
ITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANV
SVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAG
IALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE

# Metabolic_Enzyme_48_Number_of_Residues:
335

# Metabolic_Enzyme_48_Molecular_Weight:
36054

# Metabolic_Enzyme_48_Theoretical_pI:
8.73

# Metabolic_Enzyme_48_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Function:  glyceraldehyde-3-phosphate dehydrogenase activity
Function:  glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_48_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_48_Specific_Function:
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH

# Metabolic_Enzyme_48_Pathway:
map00010  Glycolysis / Gluconeogenesis

# Metabolic_Enzyme_48_Reaction:
D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+

# Metabolic_Enzyme_48_Pfam_Domain_Function:
PF02800:Gp_dh_C;
PF00044:Gp_dh_N

# Metabolic_Enzyme_48_Signals:
None

# Metabolic_Enzyme_48_Transmembrane_Regions:
None

# Metabolic_Enzyme_48_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_48_EC_Link:
EC 1.2.1.12

# Metabolic_Enzyme_48_GenBank_ID_Protein:
31645

# Metabolic_Enzyme_48_SwissProt_ID:
G3P_HUMAN (P04406)

# Metabolic_Enzyme_48_swissprot_Name:
Not Available

# Metabolic_Enzyme_48_Genecard_id:
GAPDH

# Metabolic_Enzyme_48_Geneatlas_id:
GAPDH

# Metabolic_Enzyme_48_hgnc_id:
HGNC:4141

# Metabolic_Enzyme_48_PDB_ID:
1J0X

# Metabolic_Enzyme_48_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_48_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_48_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_48_Gene_Sequence:
>1008 bp
ATGGGGAAGGTGAAGGTCGGAGTCAACGGATTTGGTCGTATTGGGCGCCTGGTCACCAGG
GCTGCTTTTAACTCTGGTAAAGTGGATATTGTTGCCATCAATGACCCCTTCATTGACCTC
AACTACATGGTTTACATGTTCCAATATGATTCCACCCATGGCAAATTCCATGGCACCGTC
AAGGCTGAGAACGGGAAGCTTGTCATCAATGGAAATCCCATCACCATCTTCCAGGAGCGA
GATCCCTCCAAAATCAAGTGGGGCGATGCTGGCGCTGAGTACGTCGTGGAGTCCACTGGC
GTCTTCACCACCATGGAGAAGGCTGGGGCTCATTTGCAGGGGGGAGCCAAAAGGGTCATC
ATCTCTGCCCCCTCTGCTGATGCCCCCATGTTCGTCATGGGTGTGAACCATGAGAAGTAT
GACAACAGCCTCAAGATCATCAGCAATGCCTCCTGCACCACCAACTGCTTAGCACCCCTG
GCCAAGGTCATCCATGACAACTTTGGTATCGTGGAAGGACTCATGACCACAGTCCATGCC
ATCACTGCCACCCAGAAGACTGTGGATGGCCCCTCCGGGAAACTGTGGCGTGATGGCCGC
GGGGCTCTCCAGAACATCATCCCTGCCTCTACTGGCGCTGCCAAGGCTGTGGGCAAGGTC
ATCCCTGAGCTAGACGGGAAGCTCACTGGCATGGCCTTCCGTGTCCCCACTGCCAACGTG
TCAGTGGTGGACCTGACCTGCCGTCTAGAAAAACCTGCCAAATATGATGACATCAAGAAG
GTGGTGAAGCAGGCGTCGGAGGGCCCCCTCAAAGGCATCCTGGGCTACACTGAGCACCAG
GTGGTCTCCTCTGACTTCAACAGCGACACCCACTCCTCCACCTTTGACGCTGGGGCTGGC
ATTGCCCTCAACGACCACTTTGTCAAGCTCATTTCCTGGTATGACAACGAATTTGGCTAC
AGCAACAGGGTGGTGGACCTCATGGCCCACATGGCCTCCAAGGAGTAA

# Metabolic_Enzyme_48_GenBank_ID_Gene:
X01677

# Metabolic_Enzyme_48_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_48_Locus:
12p13

# Metabolic_Enzyme_48_SNPs:
rs1803621; rs1065691; rs1803622; rs1136666; rs3741918; rs3741917; rs1060619; rs1060620; rs1060621; rs2886093; rs41334949; rs7971637; rs6489721; rs11549346; rs11549333; rs11549340; rs1065740; rs11549329; rs11549351; rs11549345; rs1062442; rs3211600; rs1803625; rs1062429; rs1062436; rs11549361; rs11549327; rs11549316; rs11549338; rs11549348; rs11549373; rs11549343; rs11549336; rs11549325; rs11549350; rs11549371; rs11549355; rs3203507; rs11549347; rs11266742; rs11549318; rs3211592; rs11549319; rs3199979; rs11549332; rs3741915; rs11549320; rs3211599; rs3211598; rs11552253; rs35318117; rs35043201; rs3759342; rs36015908; rs34277306; rs12425927; rs7307229; rs7977806; rs36094914; rs1043262; rs1047792; rs1063206; rs10849482; rs10849483; rs10849484; rs10849485; rs10849488; rs11064250; rs16932751; rs2072374; rs2240871; rs2240875; rs2270176; rs2270177; rs35819349; rs7132183; rs7297283; rs7300366; rs7311174; rs7316224; rs733593; rs740850; rs740851; rs740852; rs758740; rs7979706

# Metabolic_Enzyme_48_General_References:
6096136; 6096821; 2987855; 3664468; 3027061; 3170585; 1924305; 10944468; 7030790; 12665801; 7498159; 1193541; 957435

# Metabolic_Enzyme_48_References:
Not Available

# Metabolic_Enzyme_49_ID:
5438

# Metabolic_Enzyme_49_Name:
D-amino-acid oxidase

# Metabolic_Enzyme_49_Synonyms:
DAMOX; DAO; DAAO

# Metabolic_Enzyme_49_Gene_Name:
DAO

# Metabolic_Enzyme_49_Protein_Sequence:
>Daminoacid oxidase
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPN
NPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPR
ELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVN
CTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGG
IFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGP
SNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL

# Metabolic_Enzyme_49_Number_of_Residues:
347

# Metabolic_Enzyme_49_Molecular_Weight:
39475

# Metabolic_Enzyme_49_Theoretical_pI:
6.84

# Metabolic_Enzyme_49_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
Function:  D-amino-acid oxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_49_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_49_Specific_Function:
Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids

# Metabolic_Enzyme_49_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00472  D-Arginine and D-ornithine metabolism

# Metabolic_Enzyme_49_Reaction:
a D-amino acid + H2O + O2 = a 2-oxo acid + ammonia + H2O2

# Metabolic_Enzyme_49_Pfam_Domain_Function:
PF01266:DAO

# Metabolic_Enzyme_49_Signals:
1-16

# Metabolic_Enzyme_49_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_49_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_49_EC_Link:
EC 1.4.3.3

# Metabolic_Enzyme_49_GenBank_ID_Protein:
30446

# Metabolic_Enzyme_49_SwissProt_ID:
OXDA_HUMAN (P14920)

# Metabolic_Enzyme_49_swissprot_Name:
Not Available

# Metabolic_Enzyme_49_Genecard_id:
DAO

# Metabolic_Enzyme_49_Geneatlas_id:
DAO

# Metabolic_Enzyme_49_hgnc_id:
HGNC:2671

# Metabolic_Enzyme_49_PDB_ID:
Not Available

# Metabolic_Enzyme_49_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_49_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_49_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_49_Gene_Sequence:
>1044 bp
ATGCGTGTGGTGGTGATTGGAGCAGGAGTCATCGGGCTGTCCACCGCCCTCTGCATCCAT
GAGCGCTACCACTCAGTCCTGCAGCCACTGCACATAAAGGTCTACGCGGACCGCTTCACC
CCACTCACCACCACCGACGTGGCTGCCGGCCTCTGGCAGCCCTACCTTTCTGACCCCAAC
AACCCACAGGAGGCGGACTGGAGCCAACAGACCTTTGACTATCTCCTGAGCCATGTCCAT
TCTCCCAACGCTGAAAACCTGGGCCTGTTCCTAATCTCGGGCTACAACCTCTTCCATGAA
GCCATTCCGGACCCTTCCTGGAAGGACACAGTTCTGGGATTTCGGAAGCTGACCCCCAGA
GAGCTGGATATGTTCCCAGATTACGGCTATGGCTGGTTCCACACAAGCCTAATTCTGGAG
GGAAAGAACTATCTACAGTGGCTGACTGAAAGGTTAACTGAGAGGGGAGTGAAGTTCTTC
CAGCGGAAAGTGGAGTCTTTTGAGGAGGTGGCAAGAGAAGGCGCAGACGTGATTGTCAAC
TGCACTGGGGTATGGGCTGGGGCGCTACAACGAGACCCCCTGCTGCAGCCAGGCCGGGGG
CAGATCATGAAGGTGGACGCCCCTTGGATGAAGCACTTCATTCTCACCCATGACCCAGAG
AGAGGCATCTACAATTCCCCGTACATCATCCCAGGGACCCAGACAGTTACTCTTGGAGGC
ATCTTCCAGTTGGGAAACTGGAGTGAACTAAACAATATCCAGGACCACAACACCATTTGG
GAAGGCTGCTGCAGACTGGAGCCCACACTGAAGAATGCAAGAATTATTGGTGAAGCAACT
GGCTTCCGGCCAGTACGCCCCCAGATTCGGCTAGAAAGAGAACAGCTTCGCACTGGACCT
TCAAACACAGAGGTCATCCACAACTATGGCCATGGAGGCTACGGGCTCACCATCCACTGG
GGATGTGCCCTGGAGGCAGCCAAGCTCTTTGGGAGAATCCTGGAAGAAAAGAAATTGTCC
AGAATGCCACCATCCCACCTCTGA

# Metabolic_Enzyme_49_GenBank_ID_Gene:
X13227

# Metabolic_Enzyme_49_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_49_Locus:
12q24

# Metabolic_Enzyme_49_SNPs:
rs7980427; rs2111902; rs7977762; rs4964767; rs17041020; rs12579920; rs4964766; rs2070588; rs11114083; rs9706062; rs2070586; rs4964765; rs7316889; rs2070585; rs2070587; rs1808351; rs11830725; rs3741775; rs11114086; rs11114085; rs6539458; rs3918347; rs6539460; rs10861974; rs4964281; rs11837302; rs3918346; rs7967441; rs11114084; rs11114087; rs12426462; rs6539459; rs6539462; rs2302882; rs3741774; rs4964280; rs17041050; rs17041074; rs9669254; rs3825251; rs12229954; rs6539461; rs17041058; rs7962665; rs17041040; rs7975723; rs10778658; rs3741776; rs17041039; rs7302245; rs4623951; rs10861973; rs7965821; rs35388422; rs4262766; rs35658778; rs4644682; rs35550859; rs34135554; rs11415772; rs762451; rs34780883; rs11417050; rs1053875; rs3741773; rs35481176; rs11611767; rs10689951; rs10696805; rs4989798; rs35363883; rs28868909; rs12810412; rs11301485; rs34552650; rs35324225; rs7134038; rs36013571; rs7967357; rs35521446; rs4989799; rs35572480; rs36104885; rs9668314; rs5800839; rs12811324; rs11420034; rs11335673; rs11464907; rs11402329; rs11356161; rs9668327; rs7138366; rs35258241; rs34666571; rs35167645; rs10599880; rs35681690; rs12810212; rs10778659; rs12830695; rs35356685; rs36032329; rs11114080; rs11114081; rs34178394; rs10861977; rs1129027; rs12308912; rs4964762; rs4964770; rs7294679; rs7308400; rs7958090

# Metabolic_Enzyme_49_General_References:
2901986; 1356107

# Metabolic_Enzyme_49_References:
Not Available

# Metabolic_Enzyme_50_ID:
5929

# Metabolic_Enzyme_50_Name:
AMP deaminase 1

# Metabolic_Enzyme_50_Synonyms:
Myoadenylate deaminase; AMP deaminase isoform M

# Metabolic_Enzyme_50_Gene_Name:
AMPD1

# Metabolic_Enzyme_50_Protein_Sequence:
>AMP deaminase 1
MPLFKLPAEEKQIDDAMRNFAEKVFASEVKDEGGRQEISPFDVDEICPISHHEMQAHIFH
LETLSTSTEARRKKRFQGRKTVNLSIPLSETSSTKLSHIDEYISSSPTYQTVPDFQRVQI
TGDYASGVTVEDFEIVCKGLYRALCIREKYMQKSFQRFPKTPSKYLRNIDGEAWVANESF
YPVFTPPVKKGEDPFRTDNLPENLGYHLKMKDGVVYVYPNEAAVSKDEPKPLPYPNLDTF
LDDMNFLLALIAQGPVKTYTHRRLKFLSSKFQVHQMLNEMDELKELKNNPHRDFYNCRKV
DTHIHAAACMNQKHLLRFIKKSYQIDADRVVYSTKEKNLTLKELFAKLKMHPYDLTVDSL
DVHAGRQTFQRFDKFNDKYNPVGASELRDLYLKTDNYINGEYFATIIKEVGADLVEAKYQ
HAEPRLSIYGRSPDEWSKLSSWFVCNRIHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLE
NIFMPVFEATINPQADPELSVFLKHITGFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPS
YTYYAYYMYANIMVLNSLRKERGMNTFLFRPHCGEAGALTHLMTAFMIADDISHGLNLKK
SPVLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEP
LMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKVKFLGDNYLEEGPAGNDIRRTNV
AQIRMAYRYETWCYELNLIAEGLKSTE

# Metabolic_Enzyme_50_Number_of_Residues:
747

# Metabolic_Enzyme_50_Molecular_Weight:
86491

# Metabolic_Enzyme_50_Theoretical_pI:
6.89

# Metabolic_Enzyme_50_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  AMP deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_50_General_Function:
Not Available

# Metabolic_Enzyme_50_Specific_Function:
AMP deaminase plays a critical role in energy metabolism

# Metabolic_Enzyme_50_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_50_Reaction:
AMP + H2O = IMP + ammonia

# Metabolic_Enzyme_50_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_50_Signals:
None

# Metabolic_Enzyme_50_Transmembrane_Regions:
None

# Metabolic_Enzyme_50_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_50_EC_Link:
EC 3.5.4.6

# Metabolic_Enzyme_50_GenBank_ID_Protein:
10864686

# Metabolic_Enzyme_50_SwissProt_ID:
AMPD1_HUMAN (P23109)

# Metabolic_Enzyme_50_swissprot_Name:
Not Available

# Metabolic_Enzyme_50_Genecard_id:
AMPD1

# Metabolic_Enzyme_50_Geneatlas_id:
AMPD1

# Metabolic_Enzyme_50_hgnc_id:
HGNC:468

# Metabolic_Enzyme_50_PDB_ID:
Not Available

# Metabolic_Enzyme_50_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_50_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_50_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_50_Gene_Sequence:
>2244 bp
ATGCCTCTGTTCAAACTCCCAGCTGAAGAGAAACAAATTGATGATGCAATGCGCAACTTT
GCTGAAAAAGTGTTTGCCTCTGAAGTCAAAGATGAAGGAGGTCGTCAGGAGATTTCCCCC
TTTGATGTGGATGAGATCTGTCCGATTTCTCATCATGAGATGCAAGCACACATATTCCAT
CTGGAGACTCTGTCCACCTCCACAGAAGCCAGGAGAAAAAAGCGTTTCCAAGGACGGAAG
ACTGTTAATTTGTCCATTCCACTAAGTGAAACATCTTCCACCAAACTGTCCCACATTGAT
GAATACATTTCCTCATCTCCAACCTACCAGACCGTGCCTGATTTTCAGAGAGTGCAGATT
ACTGGTGACTATGCCTCTGGGGTTACAGTTGAAGATTTTGAAATTGTTTGCAAAGGTCTG
TATCGGGCACTATGCATACGTGAGAAATACATGCAGAAGTCGTTTCAGAGGTTCCCTAAA
ACCCCTTCCAAATACTTGCGGAACATTGATGGTGAGGCTTGGGTAGCAAATGAGAGCTTC
TATCCAGTCTTTACTCCTCCTGTGAAGAAGGGAGAGGACCCCTTCCGAACAGACAACCTT
CCTGAAAACCTGGGCTATCACCTCAAAATGAAGGACGGTGTAGTTTACGTCTATCCTAAT
GAAGCAGCAGTCAGCAAAGATGAGCCTAAGCCACTTCCTTACCCAAATCTGGACACCTTC
TTAGACGATATGAATTTTTTACTTGCTTTAATTGCTCAAGGACCTGTTAAGACCTATACC
CACCGGCGCCTGAAGTTCCTCTCCTCGAAGTTCCAGGTCCATCAGATGCTTAACGAGATG
GACGAGTTAAAGGAGCTGAAAAACAACCCCCACCGAGATTTTTATAACTGCAGGAAGGTG
GACACCCATATCCATGCAGCCGCTTGCATGAACCAGAAACATCTGCTGCGTTTTATTAAG
AAATCTTACCAAATTGATGCTGACAGAGTGGTCTATAGCACCAAAGAGAAGAATCTGACC
CTAAAGGAACTTTTTGCTAAATTAAAAATGCATCCTTATGACCTGACTGTTGATTCTCTG
GATGTTCATGCTGGACGCCAGACCTTCCAGCGTTTTGATAAGTTCAATGACAAATATAAT
CCTGTAGGAGCAAGTGAGCTACGGGACCTCTACTTGAAGACAGACAATTACATTAATGGG
GAATATTTTGCCACTATCATCAAGGAGGTAGGTGCGGACCTGGTGGAGGCCAAGTACCAG
CATGCTGAGCCCCGCCTGTCCATCTATGGCCGCAGTCCTGATGAGTGGAGCAAACTCTCC
TCCTGGTTCGTCTGCAATCGCATCCACTGCCCCAACATGACATGGATGATCCAGGTTCCC
AGGATCTATGATGTGTTCCGTTCCAAGAATTTCCTTCCACATTTTGGAAAAATGCTGGAG
AATATTTTCATGCCAGTGTTTGAGGCCACCATCAACCCCCAGGCTGACCCAGAACTCAGT
GTCTTCCTCAAGCATATCACTGGCTTTGACAGTGTGGATGATGAGTCCAAACACAGTGGC
CACATGTTCTCCTCCAAGAGTCCCAAGCCCCAGGAGTGGACATTGGAAAAGAATCCATCT
TACACTTACTATGCCTACTACATGTATGCAAACATCATGGTGCTCAACAGCCTGAGAAAG
GAACGAGGCATGAATACGTTTCTGTTCCGACCTCACTGTGGAGAAGCTGGAGCCCTCACC
CATCTCATGACAGCATTCATGATAGCAGATGATATCTCTCATGGCCTAAATTTAAAAAAG
AGTCCCGTGCTACAGTACTTGTTTTTCTTAGCCCAAATTCCCATCGCCATGTCACCACTA
AGTAACAATAGCCTATTTCTAGAGTATGCCAAAAATCCTTTTTTGGATTTCCTTCAGAAA
GGGCTAATGATCTCACTGTCTACAGATGACCCAATGCAATTCCACTTTACCAAGGAGCCC
CTAATGGAAGAATATGCTATTGCTGCACAAGTCTTCAAGCTGAGCACCTGTGATATGTGC
GAAGTGGCAAGGAACAGTGTCTTGCAGTGTGGAATTTCTCATGAGGAGAAAGTAAAGTTT
CTGGGCGACAATTACCTTGAGGAAGGCCCTGCTGGAAATGATATCCGGAGGACAAATGTA
GCCCAAATCCGCATGGCCTATCGCTATGAAACCTGGTGTTATGAACTCAATTTAATTGCT
GAGGGTCTTAAATCAACAGAATAA

# Metabolic_Enzyme_50_GenBank_ID_Gene:
M37931

# Metabolic_Enzyme_50_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_50_Locus:
1p13

# Metabolic_Enzyme_50_SNPs:
rs17602729; rs12566550; rs2268697; rs2010899; rs2268701; rs2336363; rs761755; rs2268700; rs2268699; rs2070986; rs743041; rs6679869; rs7531877; rs12407408; rs6683173; rs1884296; rs2268698; rs3789627; rs7515356; rs11585780; rs17032832; rs6678312; rs11102831; rs11589112; rs6697362; rs12132598; rs6663302; rs12038990; rs2268696; rs11588144; rs926938; rs6667218; rs34526199; rs35859650; rs2273268; rs34778674; rs34287100; rs949421; rs35197706; rs34257411; rs12096667; rs11451311; rs34245099; rs7518060; rs35468504; rs10698057; rs35746234; rs34418559; rs34741374; rs34355177; rs10601370; rs33984400; rs7541903; rs35241478; rs6656110; rs34630625; rs12036263; rs35985810; rs6685096; rs11412027; rs7543893; rs12354159; rs10645732; rs10611520; rs6701394; rs6701427; rs915955; rs737549; rs34909498; rs35027577; rs6697757; rs10776787; rs11577646; rs11587596; rs11799831; rs11801474; rs11803022; rs12564817; rs12753208; rs17032822; rs4537551; rs4839014; rs6537843; rs6695699; rs7516111

# Metabolic_Enzyme_50_General_References:
2345176; 1370861; 1631143; 11102975

# Metabolic_Enzyme_50_References:
Not Available

# Metabolic_Enzyme_51_ID:
5379

# Metabolic_Enzyme_51_Name:
D-aspartate oxidase

# Metabolic_Enzyme_51_Synonyms:
DASOX; DDO

# Metabolic_Enzyme_51_Gene_Name:
DDO

# Metabolic_Enzyme_51_Protein_Sequence:
>Daspartate oxidase
MDTARIAVVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTSDVAAGMLIPHTYPDTP
IHTQKQWFRETFNHLFAIANSAEAGDAGVHLVSGWQIFQSTPTEEVPFWADVVLGFRKMT
EAELKKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGWTLTRRIEDLWELHPSFDIVV
NCSGLGSRQLAGDSKIFPVRGQVLQVQAPWVEHFIRDGSGLTYIYPGTSHVTLGGTRQKG
DWNLSPDAENSREILSRCCALEPSLHGACNIREKVGLRPYRPGVRLQTELLARDGQRLPV
VHHYGHGSGGISVHWGTALEAARLVSECVHALRTPIPKSNL

# Metabolic_Enzyme_51_Number_of_Residues:
341

# Metabolic_Enzyme_51_Molecular_Weight:
37535

# Metabolic_Enzyme_51_Theoretical_pI:
7.99

# Metabolic_Enzyme_51_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
Function:  D-amino-acid oxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_51_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_51_Specific_Function:
Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate

# Metabolic_Enzyme_51_Pathway:
map00252  Alanine and aspartate metabolism

# Metabolic_Enzyme_51_Reaction:
D-aspartate + H2O + O2 = oxaloacetate + ammonia + H2O2

# Metabolic_Enzyme_51_Pfam_Domain_Function:
PF01266:DAO

# Metabolic_Enzyme_51_Signals:
1-19

# Metabolic_Enzyme_51_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_51_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_51_EC_Link:
EC 1.4.3.1

# Metabolic_Enzyme_51_GenBank_ID_Protein:
1742024

# Metabolic_Enzyme_51_SwissProt_ID:
OXDD_HUMAN (Q99489)

# Metabolic_Enzyme_51_swissprot_Name:
Not Available

# Metabolic_Enzyme_51_Genecard_id:
DDO

# Metabolic_Enzyme_51_Geneatlas_id:
DDO

# Metabolic_Enzyme_51_hgnc_id:
HGNC:2727

# Metabolic_Enzyme_51_PDB_ID:
Not Available

# Metabolic_Enzyme_51_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_51_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_51_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_51_Gene_Sequence:
>1026 bp
ATGGACACAGCACGGATTGCAGTTGTCGGGGCAGGTGTGGTGGGGCTCTCCACGGCTGTG
TGCATCTCCAAACTGGTGCCCCGATGCTCCGTTACCATCATTTCAGACAAGTTTACTCCA
GATACCACCAGTGATGTGGCAGCCGGAATGCTTATTCCTCACACTTATCCAGATACACCC
ATTCACACGCAGAAGCAGTGGTTCAGAGAAACCTTTAATCACCTCTTTGCAATTGCCAAT
TCTGCAGAAGCTGGAGATGCTGGTGTTCATTTGGTATCAGGTTGGCAGATATTTCAGAGC
ACTCCGACTGAAGAAGTGCCATTCTGGGCTGACGTGGTTCTGGGATTTCGAAAGATGACT
GAGGCTGAGCTGAAGAAATTCCCCCAGTATGTGTTTGGTCAGGCTTTTACAACCCTGAAA
TGTGAATGCCCTGCCTACCTCCCGTGGTTGGAGAAAAGGATAAAGGGAAGTGGAGGCTGG
ACACTCACTCGGCGAATAGAAGACCTGTGGGAACTTCATCCGTCCTTTGACATCGTGGTC
AACTGTTCAGGCCTTGGAAGCAGACAGCTTGCAGGAGACTCAAAGATTTTCCCTGTAAGG
GGCCAAGTCCTCCAAGTTCAGGCTCCCTGGGTGGAGCATTTTATCCGAGATGGCAGTGGG
CTGACATATATTTATCCTGGTACATCCCATGTAACCCTAGGTGGAACTAGGCAAAAAGGG
GACTGGAATCTGTCCCCGGATGCAGAAAATAGCAGAGAGATTCTTTCCCGATGCTGTGCT
CTGGAGCCCTCCCTCCACGGAGCCTGCAACATCAGGGAGAAGGTGGGCTTGAGGCCCTAC
AGGCCAGGCGTGCGACTGCAGACAGAGCTCCTTGCGCGAGATGGACAGAGGCTGCCTGTA
GTCCACCACTATGGCCATGGGAGTGGGGGCATCTCAGTGCACTGGGGCACTGCTCTGGAG
GCCGCCAGGCTGGTGAGCGAGTGTGTCCATGCCCTCAGGACCCCCATTCCCAAGTCAAAC
CTGTAG

# Metabolic_Enzyme_51_GenBank_ID_Gene:
D89858

# Metabolic_Enzyme_51_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_51_Locus:
6q21

# Metabolic_Enzyme_51_SNPs:
Not Available

# Metabolic_Enzyme_51_General_References:
9163533; 14574404

# Metabolic_Enzyme_51_References:
Not Available

# Metabolic_Enzyme_52_ID:
5969

# Metabolic_Enzyme_52_Name:
Protein-lysine 6-oxidase precursor

# Metabolic_Enzyme_52_Synonyms:
Lysyl oxidase

# Metabolic_Enzyme_52_Gene_Name:
LOX

# Metabolic_Enzyme_52_Protein_Sequence:
>Proteinlysine 6oxidase precursor
MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSL
GSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPT
ARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDD
NPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAA
EENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDE
FSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADID
CQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY

# Metabolic_Enzyme_52_Number_of_Residues:
417

# Metabolic_Enzyme_52_Molecular_Weight:
46944

# Metabolic_Enzyme_52_Theoretical_pI:
8.14

# Metabolic_Enzyme_52_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
Function:  protein-lysine 6-oxidase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_52_General_Function:
Not Available

# Metabolic_Enzyme_52_Specific_Function:
Responsible for the posttranslational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression

# Metabolic_Enzyme_52_Pathway:
Not Available

# Metabolic_Enzyme_52_Reaction:
peptidyl-L-lysyl-peptide + O2 + H2O = peptidyl-allysyl-peptide + ammonia + H2O2

# Metabolic_Enzyme_52_Pfam_Domain_Function:
PF01186:Lysyl_oxidase

# Metabolic_Enzyme_52_Signals:
1-21

# Metabolic_Enzyme_52_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_52_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_52_EC_Link:
EC 1.4.3.13

# Metabolic_Enzyme_52_GenBank_ID_Protein:
244146

# Metabolic_Enzyme_52_SwissProt_ID:
LYOX_HUMAN (P28300)

# Metabolic_Enzyme_52_swissprot_Name:
Not Available

# Metabolic_Enzyme_52_Genecard_id:
LOX

# Metabolic_Enzyme_52_Geneatlas_id:
LOX

# Metabolic_Enzyme_52_hgnc_id:
HGNC:6664

# Metabolic_Enzyme_52_PDB_ID:
Not Available

# Metabolic_Enzyme_52_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_52_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_52_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_52_Gene_Sequence:
>1254 bp
ATGCGCTTCGCCTGGACCGTGCTCCTGCTCGGGCCTTTGCAGCTCTGCGCGCTAGTGCAC
TGCGCCCCTCCCGCCGCCGGCCAACAGCAGCCCCCGCGCGAGCCGCCGGCGGCTCCGGGC
GCCTGGCGCCAGCAGATCCAATGGGAGAACAACGGGCAGGTGTTCAGCTTGCTGAGCCTG
GGCTCACAGTACCAGCCTCAGCGCCGCCGGGACCCGGGCGCCGCCGTCCCTGGTGCAGCC
AACGCCTCCGCCCAGCAGCCCCGCACTCCGATCCTGCTGATCCGCGACAACCGCACCGCC
GCGGGGCGAACGCGGACGGCCGGCTCATCTGGAGTCACCGCTGGCCGCCCCAGGCCCACC
GCCCGTCACTGGTTCCAAGCTGGCTACTCGACATCTAGAGCCCGCGAAGCTGGGCCCTCG
CGCGCGGAGAACCAGACAGCGCCGGGAGAAGTTCCTGCTCTCAGTAACCTGCGGCCGCCC
AGCCGCGTGGACGGCATGGTGGGCGACGACCCTTACAACCCCTACAAGTACTCTGACGAC
AACCCTTATTACAACTACTACGATACTTATGAAAGGCCCAGACCTGGGGGCAGGTACCGG
CCCGGATACGGCACTGGCTACTTCCAGTACGGTCTCCCAGACCTGGTGGCCGACCCCTAC
TACATCCAGGCGTCCACGTACGTGCAGAAGATGTCCATGTACAACCTGAGATGCGCGGCG
GAGGAAAACTGTCTGGCCAGTACAGCATACAGGGCAGATGTCAGAGATTATGATCACAGG
GTGCTGCTCAGATTTCCCCAAAGAGTGAAAAACCAAGGGACATCAGATTTCTTACCCAGC
CGACCAAGATATTCCTGGGAATGGCACAGTTGTCATCAACATTACCACAGTATGGATGAG
TTTAGCCACTTGTACCTGCTTGATGCCAACACCCAGAGGAGATGGGCTGAAGGCCACAAA
GCAAGTTTCTGTCTTGAAGACACATCCTGTGACTATGGCTACCACAGGCGATTTGCATGT
ACTGCACACACACAGGGATTGAGTCCTGGCTGTTATGATACCTATGGTGCAGACATAGAC
TGCCAGTGGATTGATATTACAGATGTAAAACCTGGAAACTATATCCTAAAGGTCAGTGTA
AACCCCAGCTACCTGGTTCCTGAATCTGACTATACCAACAATGTTGTGCGCTGTGACATT
CGCTACACAGGACATCATGCGTATGCCTCAGGCTGCACAATTTCACCGTATTAG

# Metabolic_Enzyme_52_GenBank_ID_Gene:
S78694

# Metabolic_Enzyme_52_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_52_Locus:
5q23.2

# Metabolic_Enzyme_52_SNPs:
rs1800449; rs17352251; rs10053942; rs3792801; rs2956540; rs3792803; rs10040971; rs2288393; rs17148773; rs10519694; rs3805442; rs3792802; rs10059661; rs41296581; rs6879333; rs2303656; rs17148776; rs3805443; rs2979862; rs17148765; rs17148788; rs7711879; rs3763024; rs2914604; rs41407546; rs34226651; rs2434980; rs2434979; rs35146783; rs2278226; rs2956539; rs34428738; rs2979868; rs2956537; rs41478244; rs3835066; rs2979865; rs34043142; rs17352491; rs6897004; rs2979870; rs2914603; rs2979863; rs2914600; rs2979869; rs10650287; rs2914599; rs34480003; rs2979867; rs35356762; rs3805444; rs2914602; rs41407947; rs2913396; rs2979866; rs2914601; rs36044767; rs41529549; rs2979864; rs6863233; rs35544795; rs10058077; rs41485947; rs11547203; rs34478531; rs3834824; rs2913397; rs840467; rs2913399; rs840466; rs7447408; rs34696124; rs41367345; rs2913398; rs10519692; rs10519693; rs11956933; rs13173506; rs13184805; rs17352083; rs17352097; rs17352686; rs17431081; rs2731646; rs2731647; rs2913400; rs2913401; rs2913402; rs2913403; rs2913405; rs2913406; rs2913407; rs2914611; rs2956538; rs2979860; rs2979872; rs3853401; rs840460; rs840461; rs840462; rs840464; rs864548; rs995687; rs995688; rs995689

# Metabolic_Enzyme_52_General_References:
1685472; 1357535; 10391127; 7902322; 1352776; 9111998; 8100215

# Metabolic_Enzyme_52_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7556

# Macromolecular_Interacting_Partner_1_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_1_Signals:
1-18

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_1_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_1_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_1_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_1_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_1_References:
16094515; 16454356; 16962796

End of HMDB00051

Beginning of HMDB00052
# Accession_No:
HMDB00052

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2006-10-25 15:46:40

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Argininosuccinic acid

# Description:
Arginosuccinic acid is a chemical compound that belongs to the class of the amino acids. Some cells synthesize it from citrulline, aspartic acid and use it as a precursor for arginine in the urea cycle or Citrulline-NO cycle.

# Synonyms:
Argininosuccinate; Argininosuccinic acid; Arginosuccinate; Arginosuccinic acid; L-Argininosuccinate; L-Argininosuccinic acid; L-Arginosuccinate; L-Arginosuccinic acid; N-(((4-amino-4-carboxybutyl)amino)iminomethyl)-L-Aspartate; N-(((4-amino-4-carboxybutyl)amino)iminomethyl)-L-Aspartic acid; N-[(4-amino-4-carboxybutyl)amidino]-L-Aspartate; N-[(4-amino-4-carboxybutyl)amidino]-L-Aspartic acid; N-[[(4-amino-4-carboxybutyl)amino]iminomethyl]-L-Aspartate; N-[[(4-amino-4-carboxybutyl)amino]iminomethyl]-L-Aspartic acid

# Chemical_IUPAC_Name:
2-[amino-(4-amino-4-carboxy-butyl)imino-methyl]aminobutanedioic acid

# Chemical_Formula:
C10H18N4O6

# Chemical_Structure:
tbl_chemical:::HMDB00052_ZOOM.png:::119283157596975197

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00052_THUMB.png:::119283157365872920

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid; guanidine; alpha-aminoacid

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
290.12265

# Molecular_Weight_Avg:
290.27313

# Smiles_String_isomeric:
N[C@@H](CCCNN=CN[C@@H](CC(O)=O)C(O)=O)C(O)=O

# Smiles_String_canonical:
NC(CCCNN=CNC(CC(O)=O)C(O)=O)C(O)=O

# KEGG_Compound_ID:
C03406

# BioCyc_ID:
Not Available

# PubChem_CID:
439998

# PubChem_SID:
8144809; 824103; 6235; 7885973

# OMIM_ID:
207900; 222470

# Metagene_ID:
Not Available

# BiGG_ID:
41790

# Wikipedia_ID:
Argininosuccinic acid

# METLIN_ID:
5115

# Ref_ID:
624188; 174426; 9844057; 15465784; 12701806; 12686410; 12403252; 12559843; 12408190; 484552

# ChEBI_ID:
15682

# CAS_Registry_Number:
2387-71-5

# InChI:
InChI=1/C10H18N4O6/c11-6(9(17)18)2-1-3-13-14-5-12-7(10(19)20)4-8(15)16/h5-7,13H,1-4,11H2,(H,12,14)(H,15,16)(H,17,18)(H,19,20)/t6-,7-/m0/s1

# Synthesis_Reference:
Not Available

# Melting_Point:
Not Available

# Melting_Point_predicted:
69.3 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
0.853 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.28 [Predicted by ALOGPS]; -6.3 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Argininosuccinic acid.pdf:::1132562193760892318

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Argininosuccinic_acid.mol:::1132723803750823271

# SDF_File_[Text]:
tbl_chemical:::HMDB00052.sdf:::119283156802450062

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00052.pdb:::11928315715297187

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Argininosuccinic acid.gif:::1132732102843434527

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00052_peaks.txt:::1156309512158846098

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Argininosuccinic acid_C.gif:::1132737667682678492

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00052_peaks.txt:::115631070269761234

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Kidneys

# deuterated:
No

# Biofluid_Location:
Blood

# Concentration_[Normal]:
Not Available


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Argininosuccinase Deficiency; Argininosuccinic Acid Lyase Deficiency; Argininosuccinic Aciduria; Argininosuccinyl-CoA lyase deficiency; ASL Deficiency; Citrullinemia; Citrullinemia Type II

# Pathway_Names:
Alanine and aspartate metabolism

# Pathway_Images:
Aspartate_and_Alanine_metabolism.jpg

# KEGG_Images:
map00252

# Pathway_Graphs:
Aspartate_and_Alanine_metabolism_Graph.jpg

# Pathway_SBMLs:
Aspartate_and_Alanine_metabolism.xml

# Metabolic_Enzyme_1_ID:
5928

# Metabolic_Enzyme_1_Name:
Argininosuccinate synthase

# Metabolic_Enzyme_1_Synonyms:
Citrulline--aspartate ligase

# Metabolic_Enzyme_1_Gene_Name:
ASS1

# Metabolic_Enzyme_1_Protein_Sequence:
>Argininosuccinate synthase
MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVF
IEDVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATG
KGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWS
MDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKD
GTTHQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAF
TMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVLKGQVYI
LGRESPLSLYNEELVSMNVQGDYEPTDATGFININSLRLKEYHRLQSKVTAK

# Metabolic_Enzyme_1_Number_of_Residues:
412

# Metabolic_Enzyme_1_Molecular_Weight:
46531

# Metabolic_Enzyme_1_Theoretical_pI:
8.18

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  argininosuccinate synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  urea cycle intermediate metabolism
Process:  arginine metabolism
Process:  arginine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
ATP + L-citrulline + L-aspartate = AMP + diphosphate + omega-N-(L-arginino)succinate

# Metabolic_Enzyme_1_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00252  Alanine and aspartate metabolism;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_1_Reaction:
ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00764:Arginosuc_synth

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 6.3.4.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
28872

# Metabolic_Enzyme_1_SwissProt_ID:
ASSY_HUMAN (P00966)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ASS1

# Metabolic_Enzyme_1_Geneatlas_id:
ASS1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:758

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1239 bp
ATGTCCAGCAAAGGCTCCGTGGTTCTGGCCTACAGTGGCGGCCTGGACACCTCGTGCATC
CTCGTGTGGCTGAAGGAACAAGGCTATGACGTCATTGCCTATCTGGCCAACATTGGCCAG
AAGGAAGACTTCGAGGAAGCCAGGAAGAAGGCACTGAAGCTTGGGGCCAAAAAGGTGTTC
ATTGAGGATGTCAGCAGGGAGTTTGTGGAGGAGTTCATCTGGCCGGCCATCCAGTCCAGC
GCACTGTATGAGGACCGCTACCTCCTGGGCACCTCTCTTGCCAGGCCCTGCATCGCCCGC
AAACAAGTGGAAATCGCCCAGCGGGAGGGGGCCAAGTATGTGTCCCACGGCGCCACAGGA
AAGGGGAACGATCAGGTCCGGTTTGAGCTCAGCTGCTACTCACTGGCCCCCCAGATAAAG
GTCATTGCTCCCTGGAGGATGCCTGAATTCTACAACCGGTTCAAGGGCCGCAATGACCTG
ATGGAGTACGCAAAGCAACACGGGATTCCCATCCCGGTCACTCCCAAGAACCCGTGGAGC
ATGGATGAGAACCTCATGCACATCAGCTACGAGGCTGGAATCCTGGAGAACCCCAAGAAC
CAAGCGCCTCCAGGTCTCTACACGAAGACCCAGGACCCAGCCAAAGCCCCCAACACCCCT
GACATTCTCGAGATCGAGTTCAAAAAAGGGGTCCCTGTGAAGGTGACCAACGTCAAGGAT
GGCACCACCCACCAGACCTCCTTGGAGCTCTTCATGTACCTGAACGAAGTCGCGGGCAAG
CATGGCGTGGGCCGTATTGACATCGTGGAGAACCGCTTCATTGGAATGAAGTCCCGAGGT
ATCTACGAGACCCCAGCAGGCACCATCCTTTACCATGCTCATTTAGACATCGAGGCCTTC
ACCATGGACCGGGAAGTGCGCAAAATCAAACAAGGCCTGGGCTTGAAATTTGCTGAGCTG
GTGTATACCGGTTTACGGCCTAGCCCTGAGTGTGAATTTGTCCGCCACTGCATCGCCAAG
TCCCAGGAGCGAGTGGAAGGGAAAGTGCAGGTGTCCGTCCTCAAGGGCCAGGTGTACATC
CTCGGCCGGGAGTCCCCACTGTCTCTCTACAATGAGGAGCTGGTGAGCATGAACGTGCAG
GGTGATTATGAGCCAACTGATGCCACCGGGTTCATCAACATCAATTCCCTCAGGCTGAAG
GAATATCATCGTCTCCAGAGCAAGGTCACTGCCAAATAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X01630

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_1_Locus:
9q34.1

# Metabolic_Enzyme_1_SNPs:
rs10901072; rs877326; rs4740158; rs6597680; rs7040665; rs11243372; rs12554609; rs12004384; rs10901047; rs914983; rs12380009; rs4740435; rs10121847; rs7042129; rs10123082; rs1760275; rs11244382; rs12685110; rs474330; rs553696; rs596317; rs506705; rs602924; rs504752; rs1215983; rs6597499; rs1215971; rs1215980; rs493389; rs543048; rs1215984; rs634432; rs666174; rs914971; rs1215970; rs1653332; rs10901080; rs590086; rs1215979; rs502901; rs666971; rs1215985; rs1215990; rs12555797; rs554629; rs7860909; rs3780588; rs1215986; rs12005118; rs1215972; rs7036163; rs2043189; rs2282219; rs914970; rs480313; rs1215988; rs12551145; rs17147029; rs2991273; rs12375699; rs641510; rs486889; rs7018779; rs17147023; rs506626; rs1215981; rs10114424; rs544701; rs618504; rs11243414; rs4322051; rs548262; rs1615006; rs11789315; rs1215982; rs12340606; rs529569; rs17147021; rs507351; rs1215991; rs7039110; rs7851267; rs1864708; rs1619401; rs652313; rs502166; rs10122141; rs668738; rs476067; rs2043191; rs10901085; rs580228; rs1215978; rs2043190; rs12003032; rs12553162; rs17147018; rs1215940; rs566037; rs640181; rs7847222; rs12000999; rs1760253; rs12343715; rs1215975; rs11243474; rs12377651; rs1215987; rs7040689; rs1215976; rs584157; rs4032; rs540140; rs4740430; rs928518; rs7854616; rs688430; rs35269064; rs11549769; rs1057484; rs35772983; rs3208841; rs2297599; rs13440219; rs13290196; rs35463800; rs11243377; rs12685093; rs3012668; rs35902422; rs5900898; rs11272909; rs3085579; rs10121464; rs28534724; rs11337242; rs28511880; rs13293193; rs35000413; rs5900899; rs12340634; rs41296095; rs35487019; rs1215977; rs35835384; rs34768057; rs3780589; rs34339017; rs11243481; rs34029710; rs34271203; rs11271310; rs11243542; rs13301636; rs12171726; rs34273046; rs4740317; rs35512453; rs1653340; rs34362653; rs34654848; rs1653334; rs11243500; rs35852270; rs12376592; rs35568745; rs12343078; rs11243395; rs28440121; rs34248043; rs12378416; rs1215941; rs12375712; rs28665572; rs11243405; rs35797527; rs4740239; rs2313201; rs884804; rs3030699; rs34037515; rs35769425; rs34790521; rs1215989; rs35976100; rs35015356; rs2297598; rs10114733; rs6151195; rs41302903; rs928517; rs12344308; rs2915535; rs28634784; rs35889473; rs884803; rs35476109; rs34850609; rs596698; rs13288900; rs34421800; rs35943966; rs534737; rs28530182; rs2116393; rs11243400; rs35581111; rs12553789; rs28633982; rs4740161; rs34599158; rs35204727; rs631908; rs13288740; rs7025952; rs1467802; rs11788148; rs35842179; rs11243523; rs11243545; rs7030804; rs34149601; rs7855232; rs35220375; rs28587006; rs11244367; rs12352216; rs11244364; rs7043097; rs34734822; rs36233815; rs2071367; rs35688375; rs10793902; rs10901110; rs11244343; rs12236605; rs12337532; rs12342208; rs12345660; rs2313079; rs3087691; rs4237122; rs7041914; rs7851772; rs7865294; rs7869828; rs928516

# Metabolic_Enzyme_1_General_References:
6194510; 6321498; 11941481; 2788888; 9150948; 2358466; 1943692; 7977368; 8792870; 11708871; 12815590

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5970

# Metabolic_Enzyme_2_Name:
Argininosuccinate lyase

# Metabolic_Enzyme_2_Synonyms:
Arginosuccinase; ASAL

# Metabolic_Enzyme_2_Gene_Name:
ASL

# Metabolic_Enzyme_2_Protein_Sequence:
>Argininosuccinate lyase
MASESGKLWGGRFVGAVDPIMEKFNASIAYDRHLWEVDVQGSKAYSRGLEKAGLLTKAEM
DQILHGLDKVAEEWAQGTFKLNSNDEDIHTANERRLKELIGATAGKLHTGRSRNDQVVTD
LRLWMRQTCSTLSGLLWELIRTMVDRAEAERDVLFPGYTHLQRAQPIRWSHWILSHAVAL
TRDSERLLEVRKRINVLPLGSGAIAGNPLGVDRELLRAELNFGAITLNSMDATSERDFVA
EFLFWASLCMTHLSRMAEDLILYCTKEFSFVQLSDAYSTGSSLMPQKKNPDSLELIRSKA
GRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFEVSDTMSAVLQVATGVISTLQIHQENM
GQALSPDMLATDLAYYLVRKGMPFRQAHEASGKAVFMAETKGVALNQLSLQELQTISPLF
SGDVICVWDYGHSVEQYGALGGTARSSVDWQIRQVRALLQAQQA

# Metabolic_Enzyme_2_Number_of_Residues:
464

# Metabolic_Enzyme_2_Molecular_Weight:
51659

# Metabolic_Enzyme_2_Theoretical_pI:
6.45

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
2-(omega-N-L-arginino)succinate = fumarate + L-arginine

# Metabolic_Enzyme_2_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00252  Alanine and aspartate metabolism;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_2_Reaction:
(N(omega)-L-arginino)succinate = fumarate + L-arginine

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00206:Lyase_1

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 4.3.2.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
28878

# Metabolic_Enzyme_2_SwissProt_ID:
ARLY_HUMAN (P04424)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ASL

# Metabolic_Enzyme_2_Geneatlas_id:
ASL

# Metabolic_Enzyme_2_hgnc_id:
HGNC:746

# Metabolic_Enzyme_2_PDB_ID:
1K62

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>1395 bp
ATGGCCTCGGAGAGTGGGAAGCTTTGGGGTGGCCGGTTTGTGGGTGCAGTGGACCCCATC
ATGGAGAAGTTCAACGCGTCCATTGCCTACGACCGGCACCTTTGGGAGGTGGATGTTCAA
GGCAGCAAAGCCTACAGCAGGGGCCTGGAGAAGGCAGGGCTCCTCACCAAGGCCGAGATG
GACCAGATACTCCATGGCCTAGACAAGGTGGCTGAGGAGTGGGCCCAGGGCACCTTCAAA
CTGAACTCCAATGATGAGGACATCCACACAGCCAATGAGCGCCGCCTGAAGGAGCTCATT
GGTGCAACGGCAGGGAAGCTGCACACGGGACGGAGCCGGAATGACCAGGTGGTCACAGAC
CTCAGGCTGTGGATGCGGCAGACCTGCTCCACGCTCTCGGGCCTCCTCTGGGAGCTCATT
AGGACCATGGTGGATCGGGCAGAGGCGGAACGTGATGTTCTCTTCCCGGGGTACACCCAT
TTGCAGAGGGCCCAGCCCATCCGCTGGAGCCACTGGATTCTGAGCCACGCCGTGGCACTG
ACCCGAGACTCTGAGCGGCTGCTGGAGGTGCGGAAGCGGATCAATGTCCTGCCCCTGGGG
AGTGGGGCCATTGCAGGCAATCCCCTGGGTGTGGACCGAGAGCTGCTCCGAGCAGAACTC
AACTTTGGGGCCATCACTCTCAACAGCATGGATGCCACTAGTGAGCGGGACTTTGTGGCC
GAGTTCCTGTTCTGGCGTTCGCTGTGCATGACCCATCTCAGCAGGATGGCCGAGGACCTC
ATCCTCTACTGCACCAAGGAATTCAGCTTCGTGCAGCTCTCAGATGCCTACAGCACGGGA
AGCAGCCTGATGCCCCAGAAGAAAAACCCCGACAGTTTGGAGCTGATCCGGAGCAAGGCT
GGGCGTGTGTTTGGGCGGTGTGCCGGGCTCCTGATGACCCTCAAGGGACTTCCCAGCACC
TACAACAAAGACTTACAGGAGGACAAGGAAGCTGTGTTTGAAGTGTCAGACACTATGAGT
GCCGTGCTCCAGGTGGCCACTGGCGTCATCTCTACGCTGCAGATTCACCAAGAGAACATG
GGACAGGCTCTCAGCCCCGACATGCTGGCCACTGACCTTGCCTATTACCTGGTCCGCAAA
GGGATGCCATTCCGCCAGGCCCATGAGGCCTCCGGGAAAGCTGTGTTCATGGCCGAGACC
AAGGGGGTCGCCCTCAACCAGCTGTCACTGCAGGAGCTGCAGACCATCAGCCCCCTGTTC
TCGGGCGACGTGATCTGCGTGTGGGACTACCGGCACAGTGTGGAGCAGTATGGTGCCCTG
GGCGGCACTGCGCGCTCCAGCGTCGACTGGCAAATCCGCCAGGTGCGGGCGCTACTGCAG
GCACAGCAGGCCTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
Y00753

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_2_Locus:
7cen-q11.2

# Metabolic_Enzyme_2_SNPs:
rs465359; rs160644; rs462853; rs1167406; rs1144895; rs313830; rs313829; rs12530898; rs1167408; rs2460432; rs160648; rs1183245; rs780998; rs2220626; rs10276931; rs12536292; rs316336; rs160647; rs160657; rs160646; rs160645; rs313831; rs697969; rs7455802; rs7455801; rs3116476; rs28941472; rs3107306; rs28940585; rs160643; rs34720698; rs2292938; rs35348667; rs4281011; rs160649; rs35930194; rs313828; rs13247295; rs35529535; rs34583147; rs34661440; rs6955131; rs160656; rs1144894; rs35350184; rs6967430; rs313833; rs313832; rs10699464; rs28447397; rs28566023; rs160543; rs35718690; rs7812266; rs10247708; rs160642; rs35701961; rs1167411; rs10234562; rs12531358; rs12532327; rs160652; rs160654; rs697970; rs709609

# Metabolic_Enzyme_2_General_References:
3391281; 3463959; 2644168; 9256435; 11747432; 1705937; 2263616; 12408190

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5857

# Metabolic_Enzyme_3_Name:
Adenylosuccinate lyase

# Metabolic_Enzyme_3_Synonyms:
Adenylosuccinase; ASL; ASASE

# Metabolic_Enzyme_3_Gene_Name:
ADSL

# Metabolic_Enzyme_3_Protein_Sequence:
>Adenylosuccinate lyase
MAAGGDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDE
QIQEMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTD
LIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLC
MDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITG
QTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMR
SERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISE
GLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGD
NDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKA
ELCL

# Metabolic_Enzyme_3_Number_of_Residues:
484

# Metabolic_Enzyme_3_Molecular_Weight:
54890

# Metabolic_Enzyme_3_Theoretical_pI:
7.12

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  lyase activity
Function:  carbon-nitrogen lyase activity
Function:  amidine-lyase activity
Function:  adenylosuccinate lyase activity
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine ribonucleotide biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
6-N-(1,2-dicarboxyethyl)AMP = fumarate + AMP

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism;
 map00252  Alanine and aspartate metabolism

# Metabolic_Enzyme_3_Reaction:
(1) N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP; (2) (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00206:Lyase_1

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 4.3.2.2

# Metabolic_Enzyme_3_GenBank_ID_Protein:
28904

# Metabolic_Enzyme_3_SwissProt_ID:
PUR8_HUMAN (P30566)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ADSL

# Metabolic_Enzyme_3_Geneatlas_id:
ADSL

# Metabolic_Enzyme_3_hgnc_id:
HGNC:291

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>1455 bp
ATGGCGGCTGGAGGCGATCATGGTTCGCCCGACAGCTACCGCTCACCTCTTGCCTCCCGC
TATGCCAGCCCGGAGATGTGCTTCGTGTTTAGCGACAGGTATAAATTCCGGACATGGCGG
CAGCTGTGGCTGTGGCTGGCGGAGGCCGAGCAGACATTGGGTTTGCCTATCACAGATGAA
CAAATCCAGGAGATGAAATCAAACCTGGAGAACATAGACTTCAAGATGGCAGCTGAGGAA
GAGAAACGTTTACGACATGATGTGATGGCTCACGTGCACACATTTGGCCACTGCTGTCCA
AAAGCTGCAGGCATTATTCACCTTGGTGCTACTTCTTGCTATGTTGGAGACAATACTGAC
TTGATTATTCTTAGAAATGCACTTGACCTGCTTTTGCCAAAGCTTGCCAGAGTGATCTCT
CGGCTTGCCGACTTTGCTAAGGAACGAGCCAGTCTACCCACATTAGGTTTCACACATTTC
CAGCCTGCACAGCTGACCACAGTTGGGAAACGTTGCTGTCTTTGGATTCAGGATCTTTGC
ATGGATCTCCAGAACTTGAAGCGTGTCCGAGATGACCTGCGCTTCCGGGGAGTAAAGGGT
ACCACTGGCACTCAGGCCAGTTTCCTGCAGCTCTTTGAGGGAGATGACCATAAGGTAGAG
CAGCTTGACAAGATGGTGACAGAAAAGGCAGGATTTAAGAGAGCTTTCATCATCACAGGG
CAGACATATACACGAAAAGTGGATATTGAAGTACTGTCTGTGCTGGCTAGCTTGGGGGCA
TCAGTGCACAAGATTTGCACCGACATACGCCTCCTGGCAAACCTCAAGGAGATGGAGGAA
CCCTTTGAAAAACAGCAGATTGGCTCAAGTGCGATGCCATATAAGCGGAATCCCATGCGT
TCAGAACGTTGCTGCAGTCTTGCCCGCCACCTGATGACCCTTGTCATGGACCCGCTACAG
ACAGCATCTGTCCAGTGGTTTGAACGCACACTGGATGATAGTGCCAACCGACGGATCTGT
TTGGCCGAGGCATTTCTTACCGCAGATACTATATTGAATACGCTGCAGAACATTTCTGAA
GGATTGGTCGTGTACCCCAAAGTAATTGAACGGCGCATTCGGCAAGAGCTGCCTTTCATG
GCCACAGAGAACATCATCATGGCCATGGTCAAAGCTGGAGGTAGCCGCCAGGATTGCCAT
GAGAAAATCAGAGTGCTTTCTCAGCAGGCAGCTTCTGTGGTTAAGCAGGAAGGGGGTGAC
AATGACCTCATAGAGCGTATCCAGGTTGATGCCTACTTCAGTCCCATTCACTCCCAGTTG
GATCATTTACTGGATCCTTCTTCTTTCACTGGTCGTGCCTCCCAGCAGGTGCAGAGATTC
TTAGAAGAGGAGGTGTATCCCCTGTTAAAACCATATGAAAGCGTGATGAAGGTGAAAGCA
GAATTATGTCTGTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X65867

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_3_Locus:
22q13.1|22q13.2

# Metabolic_Enzyme_3_SNPs:
rs2068470; rs3788578; rs3788579; rs3788577; rs9611321; rs8135371; rs7291418; rs17001846; rs10854729; rs11913275; rs2280790; rs2075764; rs12160297; rs5757922; rs17001863; rs17001848; rs17001857; rs4321458; rs2006965; rs909669; rs12484610; rs5757921; rs8192461; rs11089991; rs8192457; rs34396910; rs8192454; rs2735668; rs11703124; rs8192453; rs8192458; rs2743718; rs17001854; rs5995848; rs2743725; rs2735660; rs2735669; rs34476033; rs2735672; rs4820411; rs2743716; rs6001886; rs35043528; rs35572733; rs5995847; rs2743723; rs2735665; rs10427931; rs11089990; rs2743721; rs12170384; rs2743728; rs2743719; rs8192455; rs2735667; rs8192460; rs1882824; rs5757924; rs36099663; rs2735663; rs2735673; rs2743717; rs10427911; rs28699192; rs2743726; rs3830737; rs2743724; rs7285719; rs6001887; rs8192452; rs28642715; rs9611322; rs5750935; rs2735664; rs2735666; rs8192459; rs11431892; rs9611323; rs1882823; rs35553188; rs8142978; rs2743729; rs2743722; rs5757923; rs2735661; rs8192456; rs35401769; rs2743727; rs17001850; rs2743720; rs35128658; rs3044501; rs2743731; rs742139; rs2006961; rs909205; rs5995846; rs9607708; rs5757920; rs2743714; rs751367; rs5995845; rs5757918; rs16985898; rs9611320; rs2743732; rs35992774; rs909204; rs11320845; rs2743730; rs2743715; rs10650685; rs5757919; rs2743713; rs12484697; rs4619722; rs5995844; rs6001883; rs6001888; rs9611310; rs9611311; rs9611312; rs9611314; rs9611316; rs9611318; rs9623170

# Metabolic_Enzyme_3_General_References:
10888601; 10591208; 1302001; 9545543; 10090474; 10958654; 12368987

# Metabolic_Enzyme_3_References:
282632; 6777600

End of HMDB00052

Beginning of HMDB00053
# Accession_No:
HMDB00053

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-25 16:29:25

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Androstenedione

# Description:
A delta-4 19-carbon steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX.  Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.  It is the common precursor of male and female sex hormones. Some androstenedione is also secreted into the plasma, and may be converted in peripheral tissues to testosterone and estrogens. Androstenedione originates either from the conversion of dehydroepiandrosterone or from 17-hydroxyprogesterone. It is further converted to either testosterone or estrone. The production of adrenal androstenedione is governed by ACTH, while production of gonadal androstenedione is under control by gonadotropins.

# Synonyms:
(4)-Androsten-3,17-dione; 17-Ketotestosterone; 3,17-Dioxoandrost-4-ene; 4-Androsten-3,17-dione; 4-Androstene-3,17-dione; 4-androstenedione; delta4-androstenedione; Androst-4-ene-3,17-dione; Androstenedione; androstendione; D4-Androstene-3,17-dione; Fecundin; [4-14C]-androstenedione; [4-14C]androst-4-ene-3,17-dione

# Chemical_IUPAC_Name:
10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione

# Chemical_Formula:
C19H26O2

# Chemical_Structure:
tbl_chemical:::HMDB00053_ZOOM.png:::11928315887757840

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00053_THUMB.png:::11928315867232208

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Steroids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
ketone; alkene

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
286.19327

# Molecular_Weight_Avg:
286.40854

# Smiles_String_isomeric:
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CCC2=O

# Smiles_String_canonical:
CC12CCC3C(CCC4=CC(=O)CCC34C)C1CCC2=O

# KEGG_Compound_ID:
C00280

# BioCyc_ID:
ANDROST4ENE

# PubChem_CID:
6128

# PubChem_SID:
7885977; 933828; 598429; 3575; 8145630; 75016; 3162127; 11076124; 149021; 841441; 7847119; 11076123; 855972; 8153839

# OMIM_ID:
139300; 146110; 169170; 184700; 201810; 264300

# Metagene_ID:
Not Available

# BiGG_ID:
2210012

# Wikipedia_ID:
Androstenedione

# METLIN_ID:
2795

# Ref_ID:
3924954; 16855166; 1620285; 12096825; 15522925; 7192922; 10863969; 10421267; 6100340; 10359391; 10356596; 8706310; 11762080; 16890572; 2758640; 8877606; 15878571; 16030098; 7055782

# ChEBI_ID:
16422

# CAS_Registry_Number:
63-05-8

# InChI:
InChI=1/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1

# Synthesis_Reference:
Journal of the American Chemical Society  (1945),  67  1728-20.

# Melting_Point:
170-173 oC

# Melting_Point_predicted:
121.6 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.0578 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
0.027 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
2.75 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
2.93 [Predicted by ALOGPS]; 3 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Androstenedione.pdf:::1132562194050625366

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Androstenedione.mol:::1132723803828452408

# SDF_File_[Text]:
tbl_chemical:::HMDB00053.sdf:::11928315799624453

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00053.pdb:::119283158484168880

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::050115_P00_02_IS_1DP.zip:::117104569203712001

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:


# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050115_P00_02_IS_2DHSQC_140.png:::116655945200365634

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050115_P00_02_IS_2DHSQC_140.zip:::116655945202777332

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050115_P00_02_IS_2DHSQC_140_Assigned.png:::116655945245975254

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Androstenedione.gif:::1132732103046722250

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00053_peaks.txt:::1156309513192192671

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Androstenedione_C.gif:::1132737668293616065

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00053_peaks.txt:::1156310703709458120

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00053L.png:::119015630226397208; Medium Energy:tbl_ms:::HMDB00053M.png:::119015630168993754; High Energy:tbl_ms:::HMDB00053H.png:::119015630282979457

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane; Cytoplasm; endoplasmic reticulum

# Tissue_Location:
Adipose Tissue; Adrenal Cortex; Adrenal Gland; Fibroblasts; Gonads; Kidneys; Liver; Muscle; Placenta; Prostate; Skin; Testes; Testis

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Synovial Fluid

# Concentration_[Normal]:
Blood	0.0059 (0.0023-0.0094)	umol/L	Adult:>18_yrs_old	Both	Normal	Merck Manual
Blood	0.0022 (0.001-0.0034)	uM	Children:1-13_yrs_old	Both	Normal	Mayo Medical Laboratories 2005 Test Catalog
Blood	0.0065 (0.004 - 0.009)	uM	Adult:>18_yrs_old	N/A	Normal	16890572
Blood	0.005 (0.0024-0.007)	uM	Adolescent:13-18_yrs_old	Female	Normal	Mayo Medical Laboratories 2005 Test Catalog
Blood	0.0040 (0.0013-0.0066)	uM	Children:1-13_yrs_old	Female	Normal	Mayo Medical Laboratories 2005 Test Catalog
Blood	0.001 (0.00034-0.0017)	uM	Children:1-13_yrs_old	Female	Normal	Mayo Medical Laboratories 2005 Test Catalog
Blood	0.0057 (0.00069-0.01)	uM	Adult:>18_yrs_old	Female	Normal	Mayo Medical Laboratories 2005 Test Catalog
Cerebrospinal_Fluid(CSF)	0.00101 (0.00002-0.002)	umol/L	Adult:>18_yrs_old	N/A	Normal	1620285


# Concentration_[Abnormal]:
Blood	0.00315 (0.0- 0.0063)	umol/L	Adult:>18_yrs_old	Female	 Post-menopausal	Merck Manual


# Associated_Disorders:
 Post-menopausal; Hydroxylase Deficiency; Oligomenorrhea; Polycystic Ovary Syndrome (PCOS); Prostatic Carcinoma

# Pathway_Names:
Bile acid biosynthesis;C21-Steroid hormone metabolism;Androgen and estrogen metabolism

# Pathway_Images:
;;

# KEGG_Images:
map00120;map00140;map00150

# Pathway_Graphs:
;;

# Pathway_SBMLs:
;;

# Metabolic_Enzyme_1_ID:
5822

# Metabolic_Enzyme_1_Name:
3-oxo-5-beta-steroid 4-dehydrogenase

# Metabolic_Enzyme_1_Synonyms:
Delta(4-3- ketosteroid 5-beta-reductase; Aldo-keto reductase family 1 member D1

# Metabolic_Enzyme_1_Gene_Name:
AKR1D1

# Metabolic_Enzyme_1_Protein_Sequence:
>3oxo5betasteroid 4dehydrogenase
MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN
EHEVGEAIRE
KIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYII
EVPMAFKPGDEIYPRDENGKW
LYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLEL
ILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQ
QHDIVITAYSPLGTSRNPIWVNVSSPP
LLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERI
KENFQIFDFSLTEEEM
KDIEALNKNVRFVELLMWRDHPEYPFHDEY

# Metabolic_Enzyme_1_Number_of_Residues:
326

# Metabolic_Enzyme_1_Molecular_Weight:
37377

# Metabolic_Enzyme_1_Theoretical_pI:
7.58

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates

# Metabolic_Enzyme_1_Pathway:
map00140  C21-Steroid hormone metabolism

# Metabolic_Enzyme_1_Reaction:
4,5beta-dihydrocortisone + NADP+ = cortisone + NADPH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.3.1.3

# Metabolic_Enzyme_1_GenBank_ID_Protein:
431857

# Metabolic_Enzyme_1_SwissProt_ID:
AK1D1_HUMAN (P51857)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
AKR1D1

# Metabolic_Enzyme_1_Geneatlas_id:
AKR1D1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:388

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>981 bp

ATGGATCTCAGTGCTGCAAGTCACCGCATACCTCTAAGTGATGGAAACAGCATTCCCAT
CATCGGACTTG
GTACCTACTCAGAACCTAAATCGACCCCTAAGGGAGCCTGTGCAACAT
CGGTGAAGGTTGCTATTGACAC
AGGGTACCGACATATTGATGGGGCCTACATCTACCAA
AATGAACACGAAGTTGGGGAGGCCATCAGGGAG
AAGATAGCAGAAGGAAAGGTGCGGAG
GGAAGATATCTTCTACTGTGGAAAGCTATGGGCTACAAATCATG
TCCCAGAGATGGTCC
GCCCAACCCTGGAGAGGACACTCAGGGTCCTCCAGCTAGATTATGTGGATCTTTA
CATC
ATTGAAGTACCCATGGCCTTTAAGCCAGGAGATGAAATATACCCTAGAGATGAGAATGGC
AAATGG
TTATATCACAAGTCAAATCTGTGTGCCACTTGGGAGGCGATGGAAGCTTGCAA
AGACGCTGGCTTGGTGA
AATCCCTGGGAGTGTCCAATTTTAACCGCAGGCAGCTGGAGC
TCATCCTGAACAAGCCAGGACTCAAACA
CAAGCCAGTCAGCAACCAGGTTGAGTGCCAT
CCGTATTTCACCCAGCCAAAACTCTTGAAATTTTGCCAA
CAACATGACATTGTCATTAC
TGCATATAGCCCTTTGGGGACCAGTAGGAATCCAATCTGGGTGAATGTTT
CTTCTCCAC
CTTTGTTAAAGGATGCACTTCTAAACTCATTGGGGAAAAGGTACAATAAGACAGCAGCTC
A
AATTGTTTTGCGTTTCAACATCCAGCGAGGGGTGGTTGTCATTCCTAAAAGCTTTAAT
CTTGAAAGGATC
AAAGAAAATTTTCAGATCTTTGACTTTTCTCTCACTGAAGAAGAAAT
GAAGGACATTGAAGCCTTGAATA
AAAATGTCCGCTTTGTAGAATTGCTCATGTGGCGCG
ATCATCCTGAATACCCATTTCATGATGAATACTG
A

# Metabolic_Enzyme_1_GenBank_ID_Gene:
Z28339

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_1_Locus:
7q32-q33

# Metabolic_Enzyme_1_SNPs:
rs34703687; rs1872929; rs7780066; rs3735023; rs1872930; rs11763625; rs7799169; rs17169523; rs12540339; rs12532715; rs7780438; rs11763063; rs17169522; rs2306847; rs3805361; rs2120846; rs6467736; rs2035648; rs11982192; rs6467734; rs7799130; rs10263205; rs10280818; rs2166188; rs10269530; rs10257928; rs3805360; rs7784881; rs7795946; rs6956827; rs10226024; rs10278929; rs4728430; rs10236161; rs10954603; rs12111721; rs10228704; rs8180809; rs10276854; rs6943498; rs17169518; rs12668157; rs6980334; rs2035736; rs10263802; rs17169521; rs10954602; rs2306845; rs3805362; rs10264658; rs9642091; rs6945659; rs7799647; rs3857868; rs7784424; rs6943935; rs6951769; rs12670660; rs17169511; rs12670239; rs7799469; rs2306846; rs17169513; rs7783021; rs10279265; rs10229533; rs7784068; rs1872928; rs7803336; rs17543126; rs7784561; rs7784275; rs10244249; rs7780347; rs1038626; rs6467735; rs6977075; rs10264216; rs10279757; rs7797080; rs10228366; rs10280628; rs11762514; rs2352140; rs2035647; rs7794061; rs10280600; rs17169512; rs7784563; rs7788077; rs2882947; rs6962195; rs3816829; rs10230440; rs7784075; rs10258807; rs10085803; rs10229164; rs10236488; rs4732288; rs10244250; rs3807332; rs10246884; rs7779865; rs10231078; rs11766258; rs2465921; rs12540340; rs2465920; rs35535735; rs10274304; rs13243518; rs28601801; rs35429213; rs4732290; rs10230015; rs192475; rs13239794; rs10271851; rs4141795; rs28533201; rs11378949; rs35063839; rs10276951; rs13243967; rs9642092; rs10230284; rs28853972; rs35402657; rs34205888; rs10276855; rs6975550; rs35473428; rs28698638; rs1186272; rs13228410; rs28378643; rs13243508; rs41274197; rs34060691; rs28479257; rs36119043; rs596658; rs13244061; rs13243992; rs13243602; rs10541658; rs10280394; rs7803480; rs10230507; rs35802315; rs2465083; rs13223644; rs9642093; rs41274194; rs35504713; rs34727188; rs28609414; rs34315519; rs3857869; rs34005857; rs5887865; rs35808917; rs13243764; rs1186273; rs10264483; rs10229138; rs7784629; rs34809975; rs10259579; rs35109728; rs34437071; rs28558091; rs34613519; rs35807033; rs35415283; rs13243510; rs7787591; rs3902226; rs28547527; rs34789634; rs28587485; rs10259580; rs11762575; rs11975510; rs4311613; rs11269285; rs35579520; rs35629548; rs34739493; rs35926233; rs10227099; rs10228772; rs10233399; rs10233624; rs10235317; rs10243853; rs10258577; rs1025967; rs10260689; rs10265064; rs10954601; rs11760991; rs11764114; rs11976842; rs1487999; rs1488000; rs1586497; rs1601823; rs17169507; rs17169524; rs17277937; rs1817686; rs1994462; rs2440798; rs2440799; rs2440801; rs2465911; rs2633359; rs2709984; rs2859828; rs34416298; rs3757393; rs4732285; rs6942538; rs6950501; rs6960318; rs7785557; rs7796011; rs7796171; rs7812287; rs9692029

# Metabolic_Enzyme_1_General_References:
7508385; 11342103

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5737

# Metabolic_Enzyme_2_Name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II

# Metabolic_Enzyme_2_Synonyms:
3- beta-HSD II[Includes: 3-beta-hydroxy-Delta(5-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta-isomerase; Delta- 5-3-ketosteroid isomerase]

# Metabolic_Enzyme_2_Gene_Name:
HSD3B2

# Metabolic_Enzyme_2_Protein_Sequence:
>3 betahydroxysteroid dehydrogenase/Delta 5>4isomerase type II
MGWSCLVTGAGGLLGQRIVRLLVEEKELKEIRALDKAFRPELREEFSKLQNRTKLTVLEG
DILDEPFLKR
ACQDVSVVIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVF
IYTSSIEVAGPNSYKEIIQNG
HEEEPLENTWPTPYPYSKKLAEKAVLAANGWNLKNGDT
LYTCALRPTYIYGEGGPFLSASINEALNNNGI
LSSVGKFSTVNPVYVGNVAWAHILALR
ALRDPKKAPSVRGQFYYISDDTPHQSYDNLNYILSKEFGLRLD
SRWSLPLTLMYWIGFL
LEVVSFLLSPIYSYQPPFNRHTVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQ
KTVEW
VGSLVDRHKETLKSKTQ

# Metabolic_Enzyme_2_Number_of_Residues:
372

# Metabolic_Enzyme_2_Molecular_Weight:
42053

# Metabolic_Enzyme_2_Theoretical_pI:
8.17

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, transposing C=C bonds
Function:  steroid delta-isomerase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  3-beta-hydroxy-delta5-steroid dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_2_Specific_Function:
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids

# Metabolic_Enzyme_2_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_2_Reaction:
A 3-oxo-delta5-steroid = a 3-oxo-delta4-steroid

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01073:3Beta_HSD

# Metabolic_Enzyme_2_Signals:
1-15

# Metabolic_Enzyme_2_Transmembrane_Regions:
287-307

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.1.145;EC 5.3.3.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
184401

# Metabolic_Enzyme_2_SwissProt_ID:
3BHS2_HUMAN (P26439)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
HSD3B2

# Metabolic_Enzyme_2_Geneatlas_id:
HSD3B2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:5218

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein. Mitochondrion; mitochondrial membrane; single-pass membrane protein

# Metabolic_Enzyme_2_Gene_Sequence:
>1119 bp

ATGGGCTGGAGCTGCCTTGTGACAGGAGCAGGAGGGCTTCTGGGTCAGAGGATCGTCCG
CCTGTTGGTGG
AAGAGAAGGAACTGAAGGAGATCAGGGCCTTGGACAAGGCCTTCAGAC
CAGAATTGAGAGAGGAATTTTC
TAAGCTCCAGAACAGGACCAAGCTGACTGTACTTGAA
GGAGACATTCTGGATGAGCCATTCCTGAAAAGA
GCCTGCCAGGACGTCTCGGTCGTCAT
CCACACCGCCTGTATCATTGATGTCTTTGGTGTCACTCACAGAG
AGTCCATCATGAATG
TCAATGTGAAAGGTACCCAGCTACTGTTGGAGGCCTGTGTCCAAGCCAGTGTGCC
AGTC
TTCATCTACACCAGTAGCATAGAGGTAGCCGGGCCCAACTCCTACAAGGAAATCATCCAG
AACGGC
CACGAAGAAGAGCCTCTGGAAAACACATGGCCCACTCCATACCCGTACAGCAA
AAAGCTTGCTGAGAAGG
CTGTGCTGGCGGCTAATGGGTGGAATCTAAAAAATGGTGATA
CCTTGTACACTTGTGCGTTAAGACCCAC
ATATATCTATGGGGAAGGAGGCCCATTCCTT
TCTGCCAGTATAAATGAGGCCCTGAACAACAATGGGATC
CTGTCAAGTGTTGGAAAGTT
CTCTACAGTCAACCCAGTCTATGTTGGCAACGTGGCCTGGGCCCACATTC
TGGCCTTGA
GGGCTCTGCGGGACCCCAAGAAGGCCCCAAGTGTCCGAGGTCAATTCTATTACATCTCAG
A
TGACACGCCTCACCAAAGCTATGATAACCTTAATTACATCCTGAGCAAAGAGTTTGGC
CTCCGCCTTGAT
TCCAGATGGAGCCTTCCTTTAACCCTGATGTACTGGATTGGCTTCCT
GCTGGAAGTAGTGAGCTTCCTAC
TCAGCCCAATTTACTCCTATCAACCCCCCTTCAACC
GCCACACAGTCACATTATCAAATAGTGTGTTCAC
CTTCTCTTACAAGAAGGCTCAGCGA
GATCTGGCGTATAAGCCACTCTACAGCTGGGAGGAAGCCAAGCAG
AAAACCGTGGAGTG
GGTTGGTTCCCTTGTGGACCGGCACAAGGAGACCCTGAAGTCCAAGACTCAGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M67466

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_2_Locus:
1p13.1

# Metabolic_Enzyme_2_SNPs:
rs4986954; rs6211; rs35887327; rs6207; rs33926546; rs34412477; rs33932258; rs1819698; rs1361530; rs9282704; rs6208; rs6210; rs9282703; rs3753258; rs12411115; rs2854961; rs33920337; rs17023577; rs12044792; rs2854964; rs10923817; rs3765948; rs12411080; rs2854963; rs2793133; rs7411891; rs2854962; rs2793132; rs6676988; rs4659174; rs12062744; rs33952871; rs33963971; rs4659175; rs35983269; rs34492690; rs34177617; rs35954381; rs35344469; rs35569514; rs9282705; rs28943871; rs35613222; rs28934880; rs35486059; rs34562248; rs714748; rs10591825; rs10616581; rs34234813; rs12741109; rs3057393; rs35081017; rs3820030; rs6692175; rs10616582; rs12742063; rs12404035; rs12741125; rs36021225; rs36022499; rs5777392; rs12723698; rs35507723; rs35448442; rs35847875; rs34282330; rs10754396; rs10923815; rs10923819; rs10923820; rs11579951; rs12022215; rs12403392; rs12404131; rs12405488; rs1341018; rs17023564; rs2185556; rs2185557; rs6661603; rs947129

# Metabolic_Enzyme_2_General_References:
1944309; 1741954; 8316254; 7833923; 8126127; 7962268; 8185809; 8060486; 7893703; 7633426; 7633460; 7608265; 9719627; 10599696; 10651755; 10843183; 12050213

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5738

# Metabolic_Enzyme_3_Name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I

# Metabolic_Enzyme_3_Synonyms:
3- beta-HSD I; Trophoblast antigen FDO161G[Includes: 3-beta-hydroxy- Delta(5-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta- isomerase; Delta-5-3-ketosteroid isomerase]

# Metabolic_Enzyme_3_Gene_Name:
HSD3B1

# Metabolic_Enzyme_3_Protein_Sequence:
>3 betahydroxysteroid dehydrogenase/Delta 5>4isomerase type I
MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELREEFSKLQNKTKLTVLE
GDILDEPFLK
RACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPV
FIYTSSIEVAGPNSYKEIIQN
GHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGG
TLYTCALRPMYIYGEGSRFLSASINEALNNNG
ILSSVGKFSTVNPVYVGNVAWAHILAL
RALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRL
DSRWSFPLSLMYWIGF
LLEIVSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAK
QKTVE
WVGSLVDRHKETLKSKTQ

# Metabolic_Enzyme_3_Number_of_Residues:
373

# Metabolic_Enzyme_3_Molecular_Weight:
42252

# Metabolic_Enzyme_3_Theoretical_pI:
8.98

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, transposing C=C bonds
Function:  steroid delta-isomerase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  3-beta-hydroxy-delta5-steroid dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_3_Specific_Function:
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids

# Metabolic_Enzyme_3_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_3_Reaction:
A 3-oxo-delta5-steroid = a 3-oxo-delta4-steroid

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01073:3Beta_HSD

# Metabolic_Enzyme_3_Signals:
1-13

# Metabolic_Enzyme_3_Transmembrane_Regions:
288-308

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.1.1.145;EC 5.3.3.1

# Metabolic_Enzyme_3_GenBank_ID_Protein:
306889

# Metabolic_Enzyme_3_SwissProt_ID:
3BHS1_HUMAN (P14060)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
HSD3B1

# Metabolic_Enzyme_3_Geneatlas_id:
HSD3B1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:5217

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein. Mitochondrion; mitochondrial membrane; single-pass membrane protein

# Metabolic_Enzyme_3_Gene_Sequence:
>1122 bp

ATGACGGGCTGGAGCTGCCTTGTGACAGGAGCAGGAGGGTTTCTGGGACAGAGGATCAT
CCGCCTCTTGG
TGAAGGAGAAGGAGCTGAAGGAGATCAGGGTCTTGGACAAGGCCTTCG
GACCAGAATTGAGAGAGGAATT
TTCTAAACTCCAGAACAAGACCAAGCTGACAGTGCTG
GAAGGAGACATTCTGGATGAGCCATTCCTGAAG
AGAGCCTGCCAGGACGTCTCGGTCAT
CATCCACACCGCCTGTATCATTGATGTCTTCGGTGTCACTCACA
GAGAGTCTATCATGA
ATGTCAATGTGAAAGGTACCCAGCTCCTGTTAGAGGCCTGTGTCCAAGCTAGTGT
GCCA
GTCTTCATCTACACCAGTAGCATAGAGGTAGCCGGGCCCAACTCCTACAAGGAAATCATC
CAGAAT
GGCCATGAAGAAGAGCCTCTGGAAAACACATGGCCCGCTCCATACCCACACAG
CAAAAAGCTTGCTGAGA
AGGCTGTACTGGCGGCTAACGGGTGGAATCTGAAAAACGGCG
GCACCCTGTACACTTGTGCCTTACGACC
CATGTATATCTATGGGGAAGGAAGCCGATTC
CTTTCTGCTAGTATAAACGAGGCCCTGAACAACAATGGG
ATCCTGTCAAGTGTTGGAAA
GTTCTCCACTGTTAACCCAGTCTATGTTGGCAATGTGGCCTGGGCCCACA
TTCTGGCCT
TGAGGGCCCTGCAGGACCCCAAGAAGGCCCCAAGCATCCGAGGACAGTTCTACTATATCT
C
AGATGACACGCCTCACCAAAGCTATGATAACCTTAATTACACCCTGAGCAAAGAGTTC
GGCCTCCGCCTT
GATTCCAGATGGAGCTTTCCTTTATCCCTGATGTATTGGATTGGCTT
CCTGCTGGAAATAGTGAGCTTCC
TACTCAGGCCAATTTACACCTATCGACCGCCCTTCA
ACCGCCACATAGTCACATTGTCAAATAGCGTATT
CACCTTCTCTTATAAGAAGGCTCAG
CGAGATCTGGCGTATAAGCCACTCTACAGCTGGGAGGAAGCCAAG
CAGAAAACGGTGGA
GTGGGTTGGTTCCCTTGTGGACCGGCACAAGGAGACCCTGAAGTCCAAGACTCAGT
GA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M27137

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
2779585; 2139411; 2082186; 2243100; 1920284; 1401999; 10391209

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5808

# Metabolic_Enzyme_4_Name:
Cytochrome P450 11B2, mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
CYPXIB2; P-450Aldo; Aldosterone synthase; ALDOS; Aldosterone-synthesizing enzyme; Steroid 18-hydroxylase; P-450C18

# Metabolic_Enzyme_4_Gene_Name:
CYP11B2

# Metabolic_Enzyme_4_Protein_Sequence:
>Cytochrome P450 11B2, mitochondrial precursor
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN

# Metabolic_Enzyme_4_Number_of_Residues:
503

# Metabolic_Enzyme_4_Molecular_Weight:
57561

# Metabolic_Enzyme_4_Theoretical_pI:
9.78

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_4_Specific_Function:
Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone

# Metabolic_Enzyme_4_Pathway:
map00140  C21-Steroid hormone metabolism;
GENES       HSA: 1584(CYP11B1) 1585(CYP11B2);
            MMU: 13072(Cyp11b2) 223628(LOC223628);
            RNO: 24293(Cyp11b1) 24294(Cyp11b2) 353498(Cyp11b3)

# Metabolic_Enzyme_4_Reaction:
corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.14.15.4;EC 1.14.15.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
181340

# Metabolic_Enzyme_4_SwissProt_ID:
C11B2_HUMAN (P19099)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CYP11B2

# Metabolic_Enzyme_4_Geneatlas_id:
CYP11B2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:2592

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_4_Gene_Sequence:
>1512 bp
ATGGCACTCAGGGCAAAGGCAGAGGTGTGCGTGGCAGCGCCCTGGCTGTGCCTGCAAAGG
GCACGGGCACTGGGCACTAGAGCCGCTCGGGCCCCTAGGACGGTGCTGCCGTTTGAAGCC
ATGCCCCAGCATCCAGGCAACAGGTGGCTGAGGCTGCTGCAGATGTGGAGGGAGCAGGGT
TATGAGCACCTGCACCTGGAGATGCACCAGACCTTCCAGGAGCTGGGGCCCATTTTCAGG
TACAACTTGGGAGGACCACGCATGGTGTGTGTGATGCTGCCGGAGGATGTGGAGAAGCTG
CAACAGGTGGACAGCCTGCATCCCTGCAGGATGATCCTGGAGCCCTGGGTGGCCATCAGA
CAACATCGTGGGCACAAATGTGGCGTGTTCTTGTTGAATGGGCCTGAATGGCGCTTCAAC
CGATTGCGGCTGAACCCAGATGTGCTGTCGCCCAAGGCCGTGCAGAGGTTCCTCCCGATG
GTGGATGCAGTGGCCAGGGACTTTTCCCAGGCCCTGAGGAAGAAGGTGCTGCAGAACGCC
CGGGGGAGCCTGACCCTGGACGTCCAGCCCAGCATCTTCCACTACACCATAGAAGCCAGC
AACTTAGCTCTTTTTGGAGAGCGGCTGGGCCTGGTTGGCCACAGCCCCAGTTCTGCCAGC
CTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCACCGTCCAGCTCATGTTCATG
CCCAGGAGCCTGTCTCGCTGGATCAGCCCCAAGGTGTGGAAGGAGCACTTTGAGGCCTGG
GACTGCATCTTCCAGTACGGTGACAACTGTATCCAGAAAATCTACCAGGAACTGGCCTTC
AACCGCCCTCAACACTACACAGGCATCGTGGCAGAGCTCCTGTTGAAGGCGGAACTGTCA
CTAGAAGCCATCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCGTGGACACGACAGCG
TTTCCGTTGCTGATGACGCTCTTTGAGCTGGCTCGGAACCCCGACGTGCAGCAGATCCTG
CGCAAGGAGAGCCTGGCCGCCGCAGCCAGCATCAGTGAACATCCCCAGAAGGCAACCACC
GAGCTGCCCTTGCTGCGGGCGGCCCTCAAGGAGACCTTGAGGCTCTACCCTGTGGGTCTG
TTTTTGGAGCGAGTGGTGAGCTCAGACTTGGTGCTTCAGAACTACCACATCCCAGCTGGG
ACATTGGTACAGGTTTTCCTCTACTCGCTGGGTCGCAATGCCGCCTTGTTCCCGAGGCCT
GAGCGGTATAATCCCCAGCGCTGGCTAGACATCAGGGGCTCCGGCAGGAACTTGCACCAC
GTGCCCTTTGGCTTTGGCATGCGCCAGTGCCTCGGGCGGCGCCTGGCAGAGGCAGAGATG
CTGCTGCTGCTGCACCACGTGCTGAAGCGCTTCCTGGTGGAGACACTAACTCAAGAGGAC
ATAAAGATGGTCTACAGCTTCATATTGAGGCCTGGCACGTCCCCCCTCCTCACTTTCAGA
GCGATTAACTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M32881

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_4_Locus:
8q21-q22

# Metabolic_Enzyme_4_SNPs:
rs4545; rs4544; rs6441; rs4537; rs4539; rs5312; rs6438; rs4536; rs4543; rs4538; rs5310; rs5313; rs5281; rs4546; rs3802230; rs3839864; rs3097; rs3802228; rs3201271; rs6431; rs6435; rs7461740; rs6397; rs6432; rs6429; rs11781816; rs6421; rs10107682; rs10090630; rs4072020; rs6399; rs10096239; rs6396; rs10099658; rs4736320; rs6433; rs7836572; rs13276226; rs5307; rs10099052; rs6418; rs6434; rs6416; rs10086846; rs12679242; rs6414; rs10110732; rs6415; rs11779229; rs6394; rs5306; rs6413; rs10090037; rs7463212; rs1799998; rs6471583; rs11781082; rs10087214; rs6992689; rs11991278; rs6440; rs12542987; rs5305; rs28931609; rs5315; rs5317; rs28930074; rs9297975; rs3201269; rs33921450; rs7463238; rs35574522; rs28390200; rs28491316; rs3201272; rs33936656; rs13257266; rs13268153; rs28531895; rs33911914; rs28361356; rs35733998; rs5895735; rs35490512; rs28526467; rs36018151; rs34144193; rs6436; rs28366703; rs13257680; rs1574565; rs5314; rs35909170; rs28394055; rs13263682; rs28615142; rs28497862; rs13252628; rs13257267; rs28659182; rs13268025; rs5895734; rs10956996; rs34951350; rs7463148; rs10623281; rs13254375; rs34884498; rs7464883; rs1800534; rs10096393; rs10108843; rs11775009; rs12546357; rs13267320; rs35431302; rs4379428; rs4736317; rs4736318; rs4736319; rs4736355; rs4736356; rs4736357; rs4736358; rs4736359; rs4736360; rs6471580; rs6471581; rs6471586; rs6651273; rs6981918; rs6987382; rs7004863; rs7011830; rs7011889; rs7011901; rs7016924; rs7460125; rs7819943; rs7820667; rs7821838; rs7824229; rs7828967; rs7831617; rs7844961; rs9643358

# Metabolic_Enzyme_4_General_References:
2592361; 2256920; 1594605; 1346492; 8439335; 9177280; 9625333; 9814506; 9931115; 10391209; 10391210; 11238478; 12788848

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5971

# Metabolic_Enzyme_5_Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2

# Metabolic_Enzyme_5_Synonyms:
Steroid 5- alpha-reductase 2; SR type 2; 5 alpha-SR2; Type II 5-alpha reductase

# Metabolic_Enzyme_5_Gene_Name:
SRD5A2

# Metabolic_Enzyme_5_Protein_Sequence:
>3oxo5alphasteroid 4dehydrogenase 2
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS
FAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCT
GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI
PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE
DYPKSRKALIPFIF

# Metabolic_Enzyme_5_Number_of_Residues:
254

# Metabolic_Enzyme_5_Molecular_Weight:
28394

# Metabolic_Enzyme_5_Theoretical_pI:
9.62

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology

# Metabolic_Enzyme_5_Pathway:
map00120  Bile acid biosynthesis;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_5_Reaction:
a 3-oxo-5alpha-steroid + acceptor = a 3-oxo-delta4-steroid + reduced acceptor

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF02544:Steroid_dh

# Metabolic_Enzyme_5_Signals:
1-34

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.3.99.5

# Metabolic_Enzyme_5_GenBank_ID_Protein:
338469

# Metabolic_Enzyme_5_SwissProt_ID:
S5A2_HUMAN (P31213)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
SRD5A2

# Metabolic_Enzyme_5_Geneatlas_id:
SRD5A2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:11285

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Microsome; microsomal membrane; multi-pass membrane protein

# Metabolic_Enzyme_5_Gene_Sequence:
>765 bp
ATGCAGGTTCAGTGCCAGCAGAGCCCAGTGCTGGCAGGCAGCGCCACTTTGGTCGCCCTT
GGGGCACTGGCCTTGTACGTCGCGAAGCCCTCCGGCTACGGGAAGCACACGGAGAGCCTG
AAGCCGGCGGCTACCCGCCTGCCAGCCCGCGCCGCCTGGTTCCTGCAGGAGCTGCCTTCC
TTCGCGGTGCCCGCGGGGATCCTCGCCCGGCAGCCCCTCTCCCTCTTCGGGCCACCTGGG
ACGGTACTTCTGGGCCTCTTCTGCGTACATTACTTCCACAGGACATTTGTGTACTCACTG
CTCAATCGAGGGAGGCCTTATCCAGCTATACTCATTCTCAGAGGCACTGCCTTCTGCACT
GGAAATGGAGTCCTTCAAGGCTACTATCTGATTTACTGTGCTGAATACCCTGATGGGTGG
TACACAGACATACGGTTTAGCTTGGGTGTCTTCTTATTTATTTTGGGAATGGGAATAAAC
ATTCATAGTGACTATATATTGCGCCAGCTCAGGAAGCCTGGAGAAATCAGCTACAGGATT
CCACAAGGTGGCTTGTTTACGTATGTTTCTGGAGCCAATTTCCTCGGTGAGATCATTGAA
TGGATCGGCTATGCCCTGGCCACTTGGTCCCTCCCAGCACTTGCATTTGCATTTTTCTCA
CTTTGTTTCCTTGGGCTGCGAGCTTTTCACCACCATAGGTTCTACCTCAAGATGTTTGAG
GACTACCCCAAATCTCGGAAAGCCCTTATTCCATTCATCTTTTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M74047

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_5_Locus:
2p23

# Metabolic_Enzyme_5_SNPs:
rs1042578; rs632148; rs9332975; rs10529926; rs28383085; rs2754530; rs2281546; rs7571644; rs2268796; rs2300701; rs11690596; rs11892064; rs12467911; rs11889731; rs413836; rs11675297; rs519704; rs2300700; rs6543634; rs2300699; rs2268794; rs522638; rs7599086; rs523349; rs2300698; rs2300697; rs12691180; rs2208532; rs6543633; rs12712320; rs13429955; rs4141419; rs7594951; rs17546253; rs765138; rs17011453; rs17011504; rs725631; rs12470143; rs9332964; rs11903331; rs6543632; rs7424544; rs4952220; rs2268797; rs9282858; rs6749019; rs9332965; rs7562326; rs13395648; rs2300702; rs2268799; rs28383036; rs10196388; rs4952197; rs4952221; rs372319; rs28745289; rs6740595; rs28383071; rs12470196; rs17011470; rs28382999; rs9332961; rs6727380; rs28383050; rs11890640; rs28383068; rs28382998; rs28383004; rs12712321; rs479847; rs28383017; rs28383018; rs28383007; rs28745302; rs28745296; rs28383054; rs2886560; rs2366065; rs7422695; rs4952222; rs28745295; rs28383078; rs28383031; rs10207755; rs1988909; rs11690694; rs11692999; rs10204002; rs28383051; rs2300703; rs28383049; rs28745303; rs28383003; rs28383038; rs9332963; rs28745281; rs28383037; rs28383047; rs28383041; rs7602349; rs28383032; rs28383014; rs28745298; rs28745291; rs6736809; rs28383005; rs2208531; rs12712322; rs28745290; rs2366060; rs28383081; rs11690495; rs28383030; rs28383025; rs28383023; rs12995898; rs12463458; rs28383076; rs28383079; rs28745283; rs2366062; rs3731586; rs1884722; rs806645; rs28383091; rs28382994; rs28382988; rs28382987; rs12468405; rs9332966; rs9332967; rs28383084; rs28383082; rs11547686; rs28383087; rs28383089; rs28383083; rs6761746; rs28383088; rs28383086; rs28383039; rs13021367; rs28383008; rs34746513; rs35284547; rs2366063; rs28383043; rs28383048; rs28383067; rs34255370; rs28383063; rs28383022; rs28383021; rs13425265; rs28383012; rs28383055; rs35977260; rs28383052; rs28383046; rs28383034; rs28383000; rs28745293; rs11904357; rs28383015; rs34454544; rs28383074; rs2268795; rs34841992; rs28383065; rs13021313; rs10200753; rs28383057; rs28745284; rs28383059; rs11892634; rs35159589; rs34361388; rs10699850; rs36115939; rs13432637; rs9332962; rs13422722; rs28383080; rs28383064; rs12477492; rs619857; rs28745287; rs34985990; rs10177204; rs6726725; rs17546042; rs28383033; rs11124263; rs28836273; rs2366061; rs28383045; rs2268798; rs28383077; rs34014922; rs13007814; rs28383066; rs28745282; rs28383053; rs28383027; rs28383011; rs28382996; rs10177203; rs28383024; rs35702549; rs28383073; rs11399152; rs34909509; rs11399151; rs28383061; rs493165; rs12994135; rs10587327; rs28383070; rs28745294; rs13432696; rs10542564; rs28383001; rs28383013; rs35847074; rs28383056; rs28383062; rs28383072; rs11421066; rs5830211; rs28383058; rs11682183; rs3831847; rs28383009; rs35741321; rs2224473; rs35752905; rs7590260; rs28383075; rs28745299; rs35208541; rs542070; rs34819358; rs12994686; rs34862482; rs34552434; rs28745285; rs9332960; rs33934330; rs35112319; rs28383029; rs6726572; rs28745300; rs34852406; rs35865269; rs10185314; rs13025727; rs28745292; rs11335627; rs6751111; rs28383040; rs28383028; rs34349298; rs28745297; rs34860585; rs7559265; rs12997007; rs34631603; rs33952006; rs2366064; rs28383044; rs28382997; rs28383035; rs28383016; rs34143326; rs28745286; rs1118795; rs28383026; rs28383060; rs34600093; rs10200758; rs28383006; rs28383069; rs34262589; rs28383042; rs3819844; rs28745288; rs36090156; rs28383010; rs494302; rs28745301; rs2666408; rs28383098; rs17605682; rs28382989; rs34082006; rs28383094; rs28383093; rs28382992; rs28382991; rs28383103; rs28383101; rs28383096; rs28383099; rs28383090; rs28382993; rs3731587; rs28383092; rs28383095; rs28383100; rs28382990; rs28383102; rs28383097; rs34507825; rs11403363; rs28382995; rs11885394; rs11894988; rs12475716; rs12712317; rs12997020; rs12997024; rs1475054; rs2224310; rs3754838; rs383806; rs4443038; rs499362; rs559555; rs599300; rs6543631; rs6732223; rs6760199; rs676033

# Metabolic_Enzyme_5_General_References:
1944596; 1505484; 1522235; 7554313; 8626825; 8768837; 9208814; 9843052; 9745434; 10501358; 10718838; 10999800; 11927504

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5683

# Metabolic_Enzyme_6_Name:
Cytochrome P450 11B1, mitochondrial precursor

# Metabolic_Enzyme_6_Synonyms:
CYPXIB1; P450C11; P-450c11; Steroid 11-beta-hydroxylase

# Metabolic_Enzyme_6_Gene_Name:
CYP11B1

# Metabolic_Enzyme_6_Protein_Sequence:
>Cytochrome P450 11B1, mitochondrial precursor
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPQRPGNRWLRLLQIWREQG
YEDLHLEVHQ
TFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAY
RQHRGHKCGVFLLNGPEWRFN
RLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQ
NARGSLTLDVQPSIFHYTIEASNLALFGERLG
LVGHSPSSASLNFLHALEVMFKSTVQL
MFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF
SRPQQYTSIVAELLLN
AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAAS
ISEHP
QKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVRVFLYSLGRNPA
LFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE
TLTQEDIKMVYSFILR
PSMCPLLTFRAIN

# Metabolic_Enzyme_6_Number_of_Residues:
503

# Metabolic_Enzyme_6_Molecular_Weight:
57530

# Metabolic_Enzyme_6_Theoretical_pI:
9.42

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_6_Specific_Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB

# Metabolic_Enzyme_6_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_6_Reaction:
a steroid + reduced adrenal ferredoxin + O2 = an 11beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_6_Signals:
1-23

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.14.15.4

# Metabolic_Enzyme_6_GenBank_ID_Protein:
181333

# Metabolic_Enzyme_6_SwissProt_ID:
C11B1_HUMAN (P15538)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
CYP11B1

# Metabolic_Enzyme_6_Geneatlas_id:
CYP11B1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:2591

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_6_Gene_Sequence:
>1512 bp

ATGGCACTCAGGGCAAAGGCAGAGGTGTGCATGGCAGTGCCCTGGCTGTCCCTGCAAAG
GGCACAGGCAC
TGGGCACGAGAGCCGCCCGGGTCCCCAGGACAGTGCTGCCCTTTGAAG
CCATGCCCCGGCGTCCAGGCAA
CAGGTGGCTGAGGCTGCTGCAGATCTGGAGGGAGCAG
GGTTATGAGGACCTGCACCTGGAAGTACACCAG
ACCTTCCAGGAACTGGGGCCCATTTT
CAGGTACGATTTGGGAGGAGCAGGCATGGTGTGTGTGATGCTGC
CGGAGGACGTGGAGA
AGCTGCAACAGGTGGACAGCCTGCATCCCCACAGGATGAGCCTGGAGCCCTGGGT
GGCC
TACAGACAACATCGTGGGCACAAATGTGGCGTGTTCTTGCTGAATGGGCCTGAATGGCGC
TTCAAC
CGATTGCGGCTGAATCCAGAAGTGCTGTCGCCCAACGCTGTGCAGAGGTTCCT
CCCGATGGTGGATGCAG
TGGCCAGGGACTTCTCCCAGGCCCTGAAGAAGAAGGTGCTGC
AGAACGCCCGGGGGAGCCTGACCCTGGA
CGTCCAGCCCAGCATCTTCCACTACACCATA
GAAGCCAGCAACTTGGCTCTTTTTGGAGAGCGGCTGGGC
CTGGTTGGCCACAGCCCCAG
TTCTGCCAGCCTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCA
CCGTCCAGC
TCATGTTCATGCCCAGGAGCCTGTCTCGCTGGACCAGCCCCAAGGTGTGGAAGGAGCACT
T
TGAGGCCTGGGACTGCATCTTCCAGTACGGCGACAACTGTATCCAGAAAATCTATCAG
GAACTGGCCTTC
AGCCGCCCTCAACAGTACACCAGCATCGTGGCGGAGCTCCTGTTGAA
TGCGGAACTGTCGCCAGATGCCA
TCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCG
TGGACACGACGGTGTTTCCCTTGCTGATGACGCT
CTTTGAGCTGGCTCGGAACCCCAAC
GTGCAGCAGGCCCTGCGCCAGGAGAGCCTGGCCGCCGCAGCCAGC
ATCAGTGAACATCC
CCAGAAGGCAACCACCGAGCTGCCCTTGCTGCGTGCGGCCCTCAAGGAGACCTTGC
GGC
TCTACCCTGTGGGTCTGTTTCTGGAGCGAGTGGCGAGCTCAGACTTGGTGCTTCAGAACT
ACCACAT
CCCAGCTGGGACATTGGTGCGCGTGTTCCTCTACTCTCTGGGTCGCAACCCC
GCCTTGTTCCCGAGGCCT
GAGCGCTATAACCCCCAGCGCTGGCTAGACATCAGGGGCTC
CGGCAGGAACTTCTACCACGTGCCCTTTG
GCTTTGGCATGCGCCAGTGCCTTGGGCGGC
GCCTGGCAGAGGCAGAGATGCTGCTGCTGCTGCACCATGT
GCTGAAACACCTCCAGGTG
GAGACACTAACCCAAGAGGACATAAAGATGGTCTACAGCTTCATATTGAGG
CCCAGCAT
GTGCCCCCTCCTCACCTTCAGAGCCATCAACTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M32879

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_6_Locus:
8q21

# Metabolic_Enzyme_6_SNPs:
rs4541; rs4534; rs5288; rs5294; rs6405; rs34620645; rs6410; rs5283; rs5290; rs6403; rs6419; rs34570566; rs5316; rs5284; rs5299; rs5301; rs7003319; rs5304; rs1134096; rs5303; rs1134095; rs5017238; rs5297; rs4736312; rs5300; rs3802229; rs6389; rs9657021; rs4310186; rs6388; rs7822986; rs6471570; rs6387; rs4535; rs4736315; rs10956991; rs5295; rs6393; rs7814006; rs7814020; rs7818826; rs4609179; rs7818953; rs11775687; rs6390; rs6398; rs10105643; rs6400; rs6392; rs12674916; rs7833415; rs6411; rs6391; rs12542799; rs6402; rs6395; rs6422; rs6409; rs5280; rs4736346; rs10093618; rs4736311; rs4471016; rs4313136; rs5292; rs28934586; rs5287; rs5282; rs4998901; rs5291; rs4998896; rs6407; rs4998898; rs4998902; rs4998900; rs4998899; rs4998903; rs4998897; rs9657022; rs5296; rs4998895; rs1137481; rs1137484; rs5302; rs35673190; rs5017237; rs1137480; rs1137485; rs12543598; rs5298; rs34274727; rs1137488; rs5017240; rs5027479; rs1137486; rs1137483; rs5027480; rs5017239; rs1137487; rs5027478; rs4998894; rs9657020; rs4999335; rs4236887; rs5286; rs13250178; rs4999334; rs35378570; rs28551743; rs36004897; rs5895733; rs34698173; rs12114482; rs28418310; rs10098023; rs4464947; rs4548164; rs4581033; rs4736308; rs4736309; rs4736310; rs4736349; rs4736350; rs6995180; rs7005638; rs7016088; rs7016594

# Metabolic_Enzyme_6_General_References:
2592361; 2401360; 7903314; 3499608; 1741400; 2022736; 9302260; 10599751; 10391209; 10391210

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5972

# Metabolic_Enzyme_7_Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1

# Metabolic_Enzyme_7_Synonyms:
Steroid 5- alpha-reductase 1; SR type 1; S5AR

# Metabolic_Enzyme_7_Gene_Name:
SRD5A1

# Metabolic_Enzyme_7_Protein_Sequence:
>3oxo5alphasteroid 4dehydrogenase 1
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF

# Metabolic_Enzyme_7_Number_of_Residues:
259

# Metabolic_Enzyme_7_Molecular_Weight:
29459

# Metabolic_Enzyme_7_Theoretical_pI:
9.07

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology

# Metabolic_Enzyme_7_Pathway:
map00120  Bile acid biosynthesis;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_7_Reaction:
a 3-oxo-5alpha-steroid + acceptor = a 3-oxo-delta4-steroid + reduced acceptor

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF02544:Steroid_dh

# Metabolic_Enzyme_7_Signals:
1-24

# Metabolic_Enzyme_7_Transmembrane_Regions:
111-131
151-171
209-229

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.3.99.5

# Metabolic_Enzyme_7_GenBank_ID_Protein:
177767

# Metabolic_Enzyme_7_SwissProt_ID:
S5A1_HUMAN (P18405)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
SRD5A1

# Metabolic_Enzyme_7_Geneatlas_id:
SRD5A1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:11284

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Microsome; microsomal membrane; multi-pass membrane protein

# Metabolic_Enzyme_7_Gene_Sequence:
>780 bp
ATGGCAACGGCGACGGGGGTGGCGGAGGAGCGCCTGCTGGCCGCGCTCGCCTACCTGCAG
TGCGCCGTGGGCTGCGCGGTCTTCGCGCGGAATCGTCAGACGAACTCAGTGTACGGCCGC
CACGCGCTGCCCAGCCACAGGCTCCGAGTGCCGGCGCGGGCCGCCTGGGTGGTGCAGGAG
CTGCCCTCGCTGGCCCTGCCGCTCTACCAGTACGCCAGCGAGTCCGCCCCGCGTCTCCGC
AGCGCGCCCAACTGCATCCTCCTGGCCATGTTCCTCGTCCACTACGGGCATCGGTGCTTA
ATTTACCCGTTTCTGATGCGAGGAGGAAAGCCTATGCCACTGTTGGCATGTACAATGGCG
ATTATGTTCTGTACCTGTAACGGCTATTTGCAAAGCAGATACTTGAGCCATTGTGCAGTG
TATGCTGATGACTGGGTAACAGATCCCCGTTTTCTAATAGGTTTTGGCTTGTGGTTAACA
GGCATGTTGATAAACATCCATTCAGATCATATCCTAAGGAATCTCAGAAAACCAGGAGAT
ACTGGATACAAAATACCAAGGGGAGGCTTATTTGAATACGTAACTGCAGCCAACTATTTT
GGAGAAATCATGGAGTGGTGTGGCTATGCCCTGGCCAGCTGGTCTGTCCAAGGCGCGGCT
TTTGCTTTCTTCACGTTTTGTTTTTTATCTGGTAGAGCAAAAGAGCATCATGAGTGGTAC
CTCCGGAAATTTGAAGAGTATCCAAAGTTCAGAAAAATTATAATTCCATTTTTGTTTTAA


# Metabolic_Enzyme_7_GenBank_ID_Gene:
M32313

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_7_Locus:
5p15

# Metabolic_Enzyme_7_SNPs:
rs8192186; rs523854; rs3822430; rs3736316; rs3297; rs8192257; rs13974; rs1042150; rs8192254; rs8192256; rs471604; rs1896670; rs693651; rs500182; rs531241; rs248805; rs566202; rs477755; rs6884552; rs494958; rs7707559; rs500058; rs8192139; rs527786; rs508415; rs248797; rs181807; rs193744; rs6872996; rs248803; rs482121; rs248806; rs501999; rs568509; rs7720479; rs1560149; rs3733773; rs1651075; rs2677933; rs7706809; rs11134173; rs540212; rs187470; rs10065299; rs11738248; rs472402; rs824809; rs6883294; rs524817; rs2307270; rs3797177; rs166050; rs4702374; rs3797179; rs477930; rs8192189; rs8192180; rs4702379; rs824810; rs8192250; rs2307268; rs6874555; rs8192131; rs8192228; rs1691052; rs7730680; rs248796; rs533251; rs484973; rs4702375; rs8192223; rs8192203; rs555257; rs7732907; rs248794; rs7707877; rs2434524; rs248799; rs10060745; rs8192178; rs494803; rs8192181; rs8192207; rs8192147; rs8192198; rs8192130; rs248798; rs168713; rs8192135; rs535981; rs8192165; rs248800; rs4702378; rs8192209; rs10055803; rs4702381; rs8192133; rs8192179; rs7714182; rs8192249; rs8192166; rs485614; rs7727273; rs248807; rs8192145; rs533109; rs8192160; rs8192213; rs8192193; rs8192224; rs530370; rs1651074; rs8192195; rs562461; rs248801; rs8192215; rs2677932; rs8192222; rs8192231; rs8192206; rs8192246; rs8192148; rs8192233; rs4702380; rs7711978; rs8192219; rs8192152; rs8192235; rs8192183; rs8192141; rs10050691; rs8192164; rs4702382; rs8192134; rs8192241; rs8192192; rs521293; rs8192232; rs8192212; rs8192154; rs8192177; rs8192242; rs8192144; rs7736897; rs8192214; rs8192142; rs3797178; rs2677947; rs8192149; rs8192210; rs8192227; rs8192184; rs8192194; rs248795; rs473262; rs824811; rs8192190; rs8192221; rs8192216; rs8192247; rs8192202; rs8192191; rs8192168; rs8192245; rs8192204; rs8192138; rs8192218; rs8192158; rs8192200; rs8192163; rs8192226; rs8192182; rs8192243; rs8192236; rs39848; rs8192208; rs1802949; rs3296; rs8192253; rs8192255; rs1802278; rs13185837; rs34666637; rs34554906; rs35245174; rs11308252; rs8192136; rs16877740; rs8192199; rs3996846; rs187469; rs8192238; rs34601393; rs524971; rs11955270; rs8192211; rs36004068; rs8192155; rs8192176; rs556181; rs33996513; rs34319431; rs13171416; rs6875453; rs183133; rs187260; rs8192156; rs8192217; rs8192167; rs11402127; rs8192150; rs8192159; rs8192185; rs8192201; rs36070666; rs173588; rs11343625; rs523584; rs2434527; rs11454295; rs8192244; rs11743462; rs8192248; rs8192162; rs8192197; rs8192146; rs248804; rs35510604; rs35595453; rs8192220; rs16877752; rs8192188; rs8192225; rs11134174; rs8192237; rs33958486; rs8192251; rs34459395; rs10044539; rs2677946; rs11357349; rs35377021; rs8192161; rs34248138; rs8192132; rs8192234; rs8192205; rs28567857; rs8192137; rs8192157; rs185092; rs8192230; rs34394317; rs35634286; rs13164181; rs11402128; rs8192239; rs472358; rs1799606; rs1651073; rs8192229; rs8192151; rs8192143; rs34105852; rs34173021; rs28393089; rs4395608; rs248802; rs16877731; rs8192240; rs8192140; rs11434052; rs7704431; rs496839; rs8192196; rs8192173; rs562705; rs34914467; rs181806; rs8192252; rs8192153; rs10037161; rs10512872; rs11948470; rs11951218; rs12716180; rs12716181; rs13166363; rs1651071; rs166049; rs16877779; rs1691053; rs193743; rs2288447; rs2434525; rs2677931; rs30434; rs39847; rs4133452; rs4702373; rs508491; rs518673; rs531290; rs571550; rs6874005; rs8192120; rs8192123; rs8192124

# Metabolic_Enzyme_7_General_References:
2339109; 1686016; 10931946; 11678334

# Metabolic_Enzyme_7_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7197

# Macromolecular_Interacting_Partner_1_Name:
Corticotropin-lipotropin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Pro-opiomelanocortin; POMC[Contains: NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin]

# Macromolecular_Interacting_Partner_1_Gene_Name:
POMC

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Corticotropinlipotropin precursor
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
267

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
29424

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Beta-endorphin and Met-enkephalin are endogenous opiates

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00976:ACTH_domain;
PF08384:NPP;
PF08035:Op_neuropeptide

# Macromolecular_Interacting_Partner_1_Signals:
1-26

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
190188

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
COLI_HUMAN (P01189)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
POMC

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
POMC

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9201

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>789 bp
TGCAGCCGCTCGGGGGCCCTGTTGCTGGCCTTGCTGCTTCAGGCCTCCATGGAAGTGCGT
GGCTGGTGCCTGGAGAGCAGCCAGTGTCAGGACCTCACCACGGAAAGCAACCTGCTGGAG
TGCATCCGGGCCTGCAAGCCCGACCTCTCGGCCGAGACTCCCATGTTCCCGGGAAATGGC
GACGAGCAGCCTCTGACCGAGAACCCCCGGAAGTACGTCATGGGCCACTTCCGCTGGGAC
CGATTCGGCCGCCGCAACAGCAGCAGCAGCGGCAGCAGCGGCGCAGGGCAGAAGCGCGAG
GACGTCTCAGCGGGCGAAGACTGCGGCCCGCTGCCTGAGGGCGGCCCCGAGCCCCGCAGC
GATGGTGCCAAGCCGGGCCCGCGCGAGGGCAAGCGCTCCTACTCCATGGAGCACTTCCGC
TGGGGCAAGCCGGTGGGCAAGAAGCGGCGCCCAGTGAAGGTGTACCCTAACGGCGCCGAG
GACGAGTCGGCCGAGGCCTTCCCCCTGGAGTTCAAGAGGGAGCTGACTGGCCAGCGACTC
CGGGAGGGAGATGGCCCCGACGGCCCTGCCGATGACGGCGCAGGGGCCCAGGCCGACCTG
GAGCACAGCCTGCTGGTGGCGGCCGAGAAGAAGGACGAGGGCCCCTACAGGATGGAGCAC
TTCCGCTGGGGCAGCCCGCCCAAGGACAAGCGCTACGGCGGTTTCATGACCTCCGAGAAG
AGCCAGACGCCCCTGGTGACGCTGTTCAAAAACGCCATCATCAAGAACGCCTACAAGAAG
GGCGAGTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M38297

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_1_Locus:
2p23.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs28932472; rs8192606; rs28932471; rs35254395; rs8192605; rs28930368; rs2071345; rs34650613; rs1042571; rs11679531; rs6713532; rs7565877; rs6713396; rs12473543; rs6756695; rs6545975; rs6756566; rs28932474; rs28932476; rs28932475; rs28932473; rs10654394; rs28932470; rs3039380; rs35411223; rs35023083; rs33950052; rs7591899; rs15461; rs2071344; rs13388660; rs9973478; rs11353932; rs13404336; rs7565427; rs34619618; rs8192607; rs35639116; rs34526166; rs10188864; rs10195561; rs11892647; rs12472851; rs13418937; rs17046887; rs17046891; rs1866146; rs2071343; rs2118404; rs2164808; rs3769671; rs3795955; rs3820935; rs6545976; rs6719226; rs6734859; rs7589318; rs7605927; rs934778

# Macromolecular_Interacting_Partner_1_General_References:
6274691; 6299668; 6314261; 3606677; 6254047; 6945581; 6267033; 6272808; 4352834; 4334191; 4338630; 4347148; 1264228; 195688; 2424570; 2839146; 7828531; 9768693; 10193875; 11244459

# Macromolecular_Interacting_Partner_1_References:
10409573; 10469007; 10599726; 10634362

# Macromolecular_Interacting_Partner_2_ID:
7546

# Macromolecular_Interacting_Partner_2_Name:
Prolactin precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
PRL

# Macromolecular_Interacting_Partner_2_Gene_Name:
PRL

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Prolactin precursor
MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN
EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG
LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
227

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
25876

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.99

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Prolactin acts primarily on the mammary gland by promoting lactation

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_2_Signals:
1-28

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
34211

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
PRL_HUMAN (P01236)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
PRL

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
PRL

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:9445

# Macromolecular_Interacting_Partner_2_PDB_ID:
1RW5

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>684 bp
ATGAACATCAAAGGATCGCCATGGAAAGGGTCCCTCCTGCTGCTGCTGGTGTCAAACCTG
CTGCTGTGCCAGAGCGTGGCCCCCTTGCCCATCTGTCCCGGCGGGGCTGCCCGATGCCAG
GTGACCCTTCGAGACCTGTTTGACCGCGCCGTCGTCCTGTCCCACTACATCCATAACCTC
TCCTCAGAAATGTTCAGCGAATTCGATAAACGGTATACCCATGGCCGGGGGTTCATTACC
AAGGCCATCAACAGCTGCCACACTTCTTCCCTTGCCACCCCCGAAGACAAGGAGCAAGCC
CAACAGATGAATCAAAAAGACTTTCTGAGCCTGATAGTCAGCATATTGCGATCCTGGAAT
GAGCCTCTGTATCATCTGGTCACGGAAGTACGTGGTATGCAAGAAGCCCCGGAGGCTATC
CTATCCAAAGCTGTAGAGATTGAGGAGCAAACCAAACGGCTTCTAGAGGGCATGGAGCTG
ATAGTCAGCCAGGTTCATCCTGAAACCAAAGAAAATGAGATCTACCCTGTCTGGTCGGGA
CTTCCATCCCTGCAGATGGCTGATGAAGAGTCTCGCCTTTCTGCTTATTATAACCTGCTC
CACTGCCTACGCAGGGATTCACATAAAATCGACAATTATCTCAAGCTCCTGAAGTGCCGA
ATCATCCACAACAACAACTGCTAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00566

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_2_Locus:
6p22.2-p21.3

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
6260780; 6325171; 2050267; 6146607; 9266104; 925136; 1126929

# Macromolecular_Interacting_Partner_2_References:
10362098; 10469684; 10530323; 10902292

# Macromolecular_Interacting_Partner_3_ID:
7549

# Macromolecular_Interacting_Partner_3_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
INS

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_3_Signals:
1-24

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
INS

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11p15.5

# Macromolecular_Interacting_Partner_3_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_3_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_3_References:
10645259; 10731533; 10902292; 10965205

# Macromolecular_Interacting_Partner_4_ID:
6946

# Macromolecular_Interacting_Partner_4_Name:
Sex hormone-binding globulin precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
SHBG; Sex steroid-binding protein; SBP; Testis-specific androgen-binding protein; ABP; Testosterone-estrogen-binding globulin; Testosterone-estradiol- binding globulin; TeBG

# Macromolecular_Interacting_Partner_4_Gene_Name:
SHBG

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Sex hormonebinding globulin precursor
MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMT
FDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGA
GPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPAS
NLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDI
PQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPL
VLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTS
FCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
402

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
43780

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.70

# Macromolecular_Interacting_Partner_4_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00054:Laminin_G_1

# Macromolecular_Interacting_Partner_4_Signals:
1-29

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
296673

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
SHBG_HUMAN (P04278)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SHBG

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SHBG

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:10839

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis (By similarity)

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1209 bp
ATGGAGAGCAGAGGCCCACTGGCTACCTCGCGCCTGCTGCTGTTGCTGCTGTTGCTACTA
CTGCGTCACACCCGCCAGGGATGGGCCCTGAGACCTGTTCTCCCCACCCAGAGTGCCCAC
GACCCTCCGGCTGTCCACCTCAGCAATGGCCCAGGACAAGAGCCTATCGCTGTCATGACC
TTTGACCTCACCAAGATCACAAAAACCTCCTCCTCCTTTGAGGTTCGAACCTGGGACCCA
GAGGGAGTGATTTTTTATGGGGATACCAACCCTAAGGATGACTGGTTTATGCTGGGACTT
CGAGACGGCAGGCCTGAGATCCAACTGCACAATCACTGGGCCCAGCTTACGGTGGGTGCT
GGACCACGGCTGGATGATGGGAGATGGCACCAGGTGGAAGTCAAGATGGAGGGGGACTCT
GTGCTGCTGGAGGTGGATGGGGAGGAGGTGCTGCGCCTGAGACAGGTCTCTGGGCCCCTG
ACCAGCAAACGCCATCCCATCATGAGGATTGCGCTTGGGGGGCTGCTCTTCCCCGCTTCC
AACCTTCGGTTGCCGCTGGTTCCTGCCCTGGATGGCTGCCTGCGCCGGGATTCCTGGCTG
GACAAACAGGCCGAGATCTCAGCATCTGCCCCCACTAGCCTCAGAAGCTGTGATGTAGAA
TCAAATCCCGGGATATTTCTCCCTCCAGGGACTCAGGCAGAATTCAATCTCCGAGACATT
CCCCAGCCTCATGCAGAGCCCTGGGCCTTCTCTTTGGACCTGGGACTCAAGCAGGCAGCA
GGCTCAGGCCACCTCCTTGCTCTTGGGACACCAGAGAACCCATCTTGGCTCAGTCTCCAC
CTCCAAGATCAAAAGGTGGTGTTGTCTTCTGGGTCGGGGCCAGGGCTGGATCTGCCCCTG
GTCTTGGGACTCCCTCTTCAGCTGAAGCTGAGTATGTCCAGGGTGGTCTTGAGCCAAGGG
TCGAAGATGAAGGCCCTTGCCCTGCCTCCCTTAGGCCTGGCTCCCCTCCTTAACCTCTGG
GCCAAGCCTCAAGGGCGTCTCTTCCTGGGGGCTTTACCAGGAGAAGACTCTTCCACCTCT
TTTTGCCTGAATGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAAC
AGAAGCCATGAGATCTGGACTCACAGCTGCCCCCAGAGCCCAGGCAATGGCACTGACGCT
TCCCATTAA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
X16349

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_4_Locus:
17p13-p12

# Macromolecular_Interacting_Partner_4_SNPs:
rs6260; rs6258; rs9282845; rs6259; rs6261; rs4987212; rs9282846; rs6257; rs9913778; rs858517; rs1799941; rs858516; rs35167070; rs34865989; rs34420533; rs35338190; rs3760213; rs8065089; rs5030659; rs13894; rs1641536; rs1641537; rs1641544; rs1642800; rs2543553; rs2955617; rs34780532; rs727428; rs858520; rs858521; rs9898876

# Macromolecular_Interacting_Partner_4_General_References:
2587256; 2608061; 3569533; 2956126; 2956125; 3702459; 3542030; 1400872; 10675319; 12065592; 7714097; 10391209

# Macromolecular_Interacting_Partner_4_References:
10362098; 10624701; 10868692; 10951152

# Macromolecular_Interacting_Partner_5_ID:
6332

# Macromolecular_Interacting_Partner_5_Name:
Cytochrome P450 17A1

# Macromolecular_Interacting_Partner_5_Synonyms:
CYPXVII; P450-C17; P450c17; Steroid 17-alpha-monooxygenase; Steroid 17-alpha-hydroxylase/17,20 lyase

# Macromolecular_Interacting_Partner_5_Gene_Name:
CYP17A1

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Cytochrome P450 17A1
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGT
KTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGA
HWQLHRRLAMATFALFKDGDQ
KLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNV
ISLICFNTSYKNGDPELNVIQNYNEGIIDNLS
KDSLVDLVPWLKIFPNKTLEKLKSHVK
IRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGP
DQDSELLSDNHILTTI
GDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRL
LLLEA
TIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPE
RFLNP
AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLP
SLEGIPKVVFLIDSFK
VKIKVRQAWREAQAEGST

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
508

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
57371

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
8.87

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Macromolecular_Interacting_Partner_5_Specific_Function:
Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty

# Macromolecular_Interacting_Partner_5_Pathway:
map00140  C21-Steroid hormone metabolism

# Macromolecular_Interacting_Partner_5_Reaction:
a steroid + AH2 + O2 = a 17alpha-hydroxysteroid + A + H2O

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00067:p450

# Macromolecular_Interacting_Partner_5_Signals:
1-24

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
EC 1.14.99.9

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
181342

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
CP17A_HUMAN (P05093)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
CYP17A1

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
CYP17A1

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:2593

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1527 bp

ATGTGGGAGCTCGTGGCTCTCTTGCTGCTTACCCTAGCTTATTTGTTTTGGCCCAAGAG
AAGGTGCCCTG
GTGCCAAGTACCCCAAGAGCCTCCTGTCCCTGCCCCTGGTGGGCAGCC
TGCCATTCCTCCCCAGACATGG
CCATATGCATAACAACTTCTTCAAGCTGCAGAAAAAA
TATGGCCCCATCTATTCTGTTCGTATGGGCACC
AAGACTACAGTGATTGTCGGCCACCA
CCAGCTGGCCAAGGAGGTGCTTATTAAGAAGGGCAAGGACTTCT
CTGGGCGGCCTCAAA
TGGCAACTCTAGACATCGCGTCCAACAACCGTAAGGGTATCGCCTTCGCTGACTC
TGGC
GCACACTGGCAGCTGCATCGAAGGCTGGCGATGGCCACCTTTGCCCTGTTCAAGGATGGC
GATCAG
AAGCTGGAGAAGATCATTTGTCAGGAAATCAGTACATTGTGTGATATGCTGGC
CACCCACAACGGACAGT
CCATAGACATCTCCTTTCCTGTCTTCGTGGCGGTAACCAATG
TCATCTCCTTGATCTGCTTCAATACCTC
CTACAAGAATGGGGACCCTGAGTTGAATGTC
ATACAGAATTACAATGAAGGCATCATAGACAACCTGAGC
AAAGACAGCCTGGTGGACCT
AGTCCCCTGGTTGAAGATTTTCCCCAACAAAACCCTGGAAAAATTAAAGA
GCCATGTTA
AAATACGAAATGATCTGCTGAATAAAATACTTGAAAATTACAAGGAGAAATTCCGGAGTG
A
CTCTATCACCAACATGCTGGACACACTGATGCAAGCCAAGATGAACTCAGATAATGGC
AATGCTGGCCCA
GATCAAGATTCAGAGCTGCTTTCAGATAACCACATTCTCACCACCAT
AGGGGACATCTTTGGGGCTGGCG
TGGAGACCACCACCTCTGTGGTTAAATGGACCCTGG
CCTTCCTGCTGCACAATCCTCAGGTGAAGAAGAA
GCTCTACGAGGAGATTGACCAGAAT
GTGGGTTTCAGCCGCACACCAACTATCAGTGACCGTAACCGTCTC
CTCCTGCTGGAGGC
CACCATCCGAGAGGTGCTTCGCCTCAGGCCCGTGGCCCCTATGCTCATCCCCCACA
AGG
CCAACGTTGACTCCAGCATCGGTGAGTTTGCTGTGGACAAGGGCACAGAAGTTATCATCA
ATCTGTG
GGCGCTGCATCACAATGAGAAGGAGTGGCACCAGCCGGATCAGTTCATGCCT
GAGCGTTTCTTGAATCCA
GCGGGGACCCAGCTCATCTCACCGTCAGTAAGCTATTTGCC
CTTCGGAGCAGGACCTCGCTCCTGTATAG
GTGAGATCCTGGCCCGCCAGGAGCTCTTCC
TCATCATGGCCTGGCTGCTGCAGAGGTTCGACCTGGAGGT
GCCAGATGATGGGCAGCTG
CCCTCCCTGGAAGGCATCCCCAAGGTGGTCTTTCTGATCGACTCTTTCAAA
GTGAAGAT
CAAGGTGCGCCAGGCCTGGAGGGAAGCCCAGGCTGAGGGTAGCACCTAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
M14564

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_5_Locus:
10q24.3

# Macromolecular_Interacting_Partner_5_SNPs:
rs762563; rs6163; rs6162; rs1042386; rs6164; rs743572; rs10883783; rs4919687; rs3781286; rs10786712; rs3781287; rs743575; rs1004467; rs4919686; rs17115100; rs3824755; rs284847; rs755443; rs17115104; rs3740397; rs284849; rs3020724; rs12254149; rs17855149; rs3211406; rs17115125; rs3020717; rs34343941; rs3020712; rs34132012; rs3020723; rs35403742; rs3020714; rs3020715; rs34431726; rs284848; rs3020719; rs3020721; rs284850; rs34983874; rs35538238; rs35144627; rs34713150; rs35165247; rs2911432; rs7922856; rs12219555; rs35745115; rs3020718; rs35115800; rs34846786; rs2911431; rs11191413; rs3020711; rs3020720; rs34485280; rs34620611; rs3020713; rs3020722; rs11191412; rs3890077; rs11191411; rs12775422; rs11191410; rs34005085; rs10509762; rs10883782; rs11191406; rs11191416; rs12242445; rs17115144; rs17115149; rs2486758; rs4919682; rs4919683; rs4919685; rs619824; rs7082755; rs7089422

# Macromolecular_Interacting_Partner_5_General_References:
3025870; 3500022; 3274893; 1964490; 2843762; 10406467; 2808364; 1714904; 1515452; 1740503; 8396144; 8245018; 8345056; 8027220; 8550762; 10720067; 11549685; 11836339; 12466376

# Macromolecular_Interacting_Partner_5_References:
15703266; 15711029

# Macromolecular_Interacting_Partner_6_ID:
6947

# Macromolecular_Interacting_Partner_6_Name:
Androgen receptor

# Macromolecular_Interacting_Partner_6_Synonyms:
Dihydrotestosterone receptor

# Macromolecular_Interacting_Partner_6_Gene_Name:
AR

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Androgen receptor
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQ
QQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSA
LECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLK
DILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELCKA
VSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAGKS
TEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQSR
DYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGP
GSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPY
GYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLE
TARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRND
CTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKLT
VSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRM
YSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDR
IIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIIS
VQVPKILSGKVKPIYFHTQ

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
919

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
98990

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
6.38

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  transcription factor activity
Function:  steroid binding
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  androgen receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Activated, but not phosphorylated, by HIPK3

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF02166:Androgen_recep;
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
178628

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
ANDR_HUMAN (P10275)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
AR

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
AR

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:644

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>2760 bp
ATGGAAGTGCAGTTAGGGCTGGGAAGGGTCTACCCTCGGCCGCCGTCCAAGACCTACCGA
GGAGCTTTCCAGAATCTGTTCCAGAGCGTGCGCGAAGTGATCCAGAACCCGGGCCCCAGG
CACCCAGAGGCCGCGAGCGCAGCACCTCCCGGCGCCAGTTTGCTGCTGCTGCAGCAGCAG
CAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAAGAGACT
AGCCCCAGGCAGCAGCAGCAGCAGCAGGGTGAGGATGGTTCTCCCCAAGCCCATCGTAGA
GGCCCCACAGGCTACCTGGTCCTGGATGAGGAACAGCAACCTTCACAGCCGCAGTCGGCC
CTGGAGTGCCACCCCGAGAGAGGTTGCGTCCCAGAGCCTGGAGCCGCCGTGGCCGCCAGC
AAGGGGCTGCCGCAGCAGCTGCCAGCACCTCCGGACGAGGATGACTCAGCTGCCCCATCC
ACGTTGTCCCTGCTGGGCCCCACTTTCCCCGGCTTAAGCAGCTGCTCCGCTGACCTTAAA
GACATCCTGAGCGAGGCCAGCACCATGCAACTCCTTCAGCAACAGCAGCAGGAAGCAGTA
TCCGAAGGCAGCAGCAGCGGGAGAGCGAGGGAGGCCTCGGGGGCTCCCACTTCCTCCAAG
GACAATTACTTAGGGGGCACTTCGACCATTTCTGACAACGCCAAGGAGTTGTGTAAGGCA
GTGTCGGTGTCCATGGGCCTGGGTGTGGAGGCGTTGGAGCATCTGAGTCCAGGGGAACAG
CTTCGGGGGGATTGCATGTACGCCCCACTTTTGGGAGTTCCACCCGCTGTGCGTCCCACT
CCTTGTGCCCCATTGGCCGAATGCAAAGGTTCTCTGCTAGACGACAGCGCAGGCAAGAGC
ACTGAAGATACTGCTGAGTATTCCCCTTTCAAGGGAGGTTACACCAAAGGGCTAGAAGGC
GAGAGCCTAGGCTGCTCTGGCAGCGCTGCAGCAGGGAGCTCCGGGACACTTGAACTGCCG
TCTACCCTGTCTCTCTACAAGTCCGGAGCACTGGACGAGGCAGCTGCGTACCAGAGTCGC
GACTACTACAACTTTCCACTGGCTCTGGCCGGACCGCCGCCCCCTCCGCCGCCTCCCCAT
CCCCACGCTCGCATCAAGCTGGAGAACCCGCTGGACTACGGCAGCGCCTGGGCGGCTGCG
GCGGCGCAGTGCCGCTATGGGGACCTGGCGAGCCTGCATGGCGCGGGTGCAGCGGGACCC
GGTTCTGGGTCACCCTCAGCCGCCGCTTCCTCATCCTGGCACACTCTCTTCACAGCCGAA
GAAGGCCAGTTGTATGGACCGTGTGGTGGTGGTGGGGGTGGTGGCGGCGGCGGCGGCGGC
GGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGAGGCGGGAGCTGTAGCCCCCTAC
GGCTACACTCGGCCCCCTCAGGGGCTGGCGGGCCAGGAAAGCGACTTCACCGCACCTGAT
GTGTGGTACCCTGGCGGCATGGTGAGCAGAGTGCCCTATCCCAGTCCCACTTGTGTCAAA
AGCGAAATGGGCCCCTGGATGGATAGCTACTCCGGACCTTACGGGGACATGCGTTTGGAG
ACTGCCAGGGACCATGTTTTGCCCATTGACTATTACTTTCCACCCCAGAAGACCTGCCTG
ATCTGTGGAGATGAAGCTTCTGGGTGTCACTATGGAGCTCTCACATGTGGAAGCTGCAAG
GTCTTCTTCAAAAGAGCCGCTGAAGGGAAACAGAAGTACCTGTGCGCCAGCAGAAATGAT
TGCACTATTGATAAATTCCGAAGGAAAAATTGTCCATCTTGTCGTCTTCGGAAATGTTAT
GAAGCAGGGATGACTCTGGGAGCCCGGAAGCTGAAGAAACTTGGTAATCTGAAACTACAG
GAGGAAGGAGAGGCTTCCAGCACCACCAGCCCCACTGAGGAGACAACCCAGAAGCTGACA
GTGTCACACATTGAAGGCTATGAATGTCAGCCCATCTTTCTGAATGTCCTGGAAGCCATT
GAGCCAGGTGTAGTGTGTGCTGGACACGACAACAACCAGCCCGACTCCTTTGCAGCCTTG
CTCTCTAGCCTCAATGAACTGGGAGAGAGACAGCTTGTACACGTGGTCAAGTGGGCCAAG
GCCTTGCCTGGCTTCCGCAACTTACACGTGGACGACCAGATGGCTGTCATTCAGTACTCC
TGGATGGGGCTCATGGTGTTTGCCATGGGCTGGCGATCCTTCACCAATGTCAACTCCAGG
ATGCTCTACTTCGCCCCTGATCTGGTTTTCAATGAGTACCGCATGCACAAGTCCCGGATG
TACAGCCAGTGTGTCCGAATGAGGCACCTCTCTCAAGAGTTTGGATGGCTCCAAATCACC
CCCCAGGAATTCCTGTGCATGAAAGCACTGCTACTCTTCAGCATTATTCCAGTGGATGGG
CTGAAAAATCAAAAATTCTTTGATGAACTTCGAATGAACTACATCAAGGAACTCGATCGT
ATCATTGCATGCAAAAGAAAAAATCCCACATCCTGCTCAAGACGCTTCTACCAGCTCACC
AAGCTCCTGGACTCCGTGCAGCCTATTGCGAGAGAGCTGCATCAGTTCACTTTTGACCTG
CTAATCAAGTCACACATGGTGAGCGTGGACTTTCCGGAAATGATGGCAGAGATCATCTCT
GTGCAAGTGCCCAAGATCCTTTCTGGGAAAGTCAAGCCCATCTATTTCCACACCCAGTGA


# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
M20132

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_6_Locus:
Xq11.2-q12

# Macromolecular_Interacting_Partner_6_SNPs:
rs9332970; rs9332971; rs9332968; rs6154; rs6153; rs6152; rs2767564; rs1926927; rs7065472; rs1337077; rs1337078; rs7064188; rs1337080; rs2255702; rs1204038; rs5918757; rs4827547; rs12007252; rs5918760; rs1204039; rs1337079; rs1926926; rs4827545; rs1572500; rs5919394; rs2361634; rs1572501; rs2207040; rs7061037; rs4827546; rs12014709; rs5919393; rs12011519; rs6624304; rs16989056; rs1361038; rs5919402; rs2361630; rs12009820; rs5918763; rs5031002; rs1337076; rs5965433; rs5918762; rs17217069; rs2361629; rs1204040; rs12010355; rs12009650; rs4827400; rs5919408; rs12862891; rs4618851; rs2885324; rs1926925; rs12009160; rs4261023; rs5918764; rs7053042; rs5919395; rs7053539; rs12007014; rs5919411; rs9282610; rs12011793; rs34899607; rs5919409; rs6625192; rs1337075; rs4993619; rs16989058; rs5919396; rs5919403; rs12396249; rs12011839; rs11795851; rs34135606; rs11797145; rs16990313; rs12011518; rs5918758; rs34070681; rs12014623; rs4393047; rs11798429; rs5919392; rs7474293; rs16990322; rs12007513; rs11497352; rs34769252; rs9332969; rs1800053; rs9332972; rs12394583; rs12558349; rs34279752; rs34542167; rs12850901; rs12835888; rs12353686; rs12855990; rs11300116; rs34908546; rs3070073; rs4281240; rs28753893; rs12856708; rs4451455; rs7061565; rs35645431; rs1577774; rs36064324; rs1361039; rs35122308; rs35099711; rs35535776; rs11461009; rs1577776; rs12833196; rs35625503; rs12846224; rs12836266; rs36110198; rs10706297; rs12834564; rs12836056; rs12849709; rs12848807; rs4827399; rs6624302; rs4500207; rs7054901; rs34043358; rs2885320; rs5016202; rs4540555; rs12833578; rs12013056; rs35809402; rs7060002; rs5918761; rs5919412; rs1577773; rs35044641; rs34070729; rs10856045; rs34434496; rs5919400; rs4489446; rs28402724; rs34642310; rs35624751; rs2361632; rs34878648; rs5965428; rs1204041; rs11380458; rs12864107; rs12837932; rs5965427; rs34951605; rs12393203; rs35953490; rs12835668; rs7055888; rs4459010; rs2878448; rs11094028; rs28580341; rs5919404; rs12832474; rs35888906; rs12864066; rs12847395; rs12395102; rs5919399; rs10622053; rs10553807; rs3070104; rs36168959; rs12840191; rs12837043; rs12848810; rs36099326; rs12009829; rs34077836; rs9699316; rs34754285; rs12851299; rs35747505; rs10564872; rs12835243; rs7052941; rs35098115; rs12859822; rs2878449; rs3795188; rs7062560; rs34742794; rs12851535; rs35630657; rs5964604; rs12849096; rs35546171; rs4497110; rs5965426; rs12401043; rs4827402; rs11799017; rs12843690; rs35819077; rs34792775; rs35617974; rs12838075; rs34664808; rs4292843; rs1577778; rs34997701; rs5918756; rs12857875; rs11428245; rs2361636; rs11424271; rs6653153; rs11367126; rs5919410; rs12843659; rs12835932; rs6625193; rs12851734; rs35316597; rs12851221; rs5016201; rs4413923; rs1577775; rs12836926; rs12856976; rs5919398; rs12851526; rs34418137; rs34604425; rs12689165; rs35377720; rs12863183; rs2361635; rs12857354; rs7065530; rs12835940; rs35020767; rs35774629; rs35847971; rs4827549; rs1577777; rs12857337; rs2223823; rs3795189; rs5919397; rs12837784; rs12836735; rs36063595; rs35442632; rs12833469; rs36075392; rs34317430; rs4446868; rs6625199; rs11316774; rs12862050; rs11094026; rs5965425; rs34851516; rs7474075; rs5965429; rs11351755; rs2070757; rs34566600; rs35506153; rs35025615; rs3032358; rs10060; rs17302090; rs1931537; rs2282289; rs2362520; rs5919413; rs5919414; rs7440

# Macromolecular_Interacting_Partner_6_General_References:
3216866; 2594783; 2342476; 3174628; 12361945; 2911578; 2293020; 2917688; 3353726; 3377788; 2546571; 3353727; 1775137; 1561105; 9096391; 10332029; 10400640; 10625666; 10930412; 12415108; 12612053; 10840043; 11906285; 1458719; 8339746; 8240973; 7937057; 7626493; 9016528; 2260966; 2082179; 1856263; 1999491; 2010552; 2062380; 1609793; 1424203; 1426313; 1487249; 1307250; 1569163; 1464650; 1430233; 1562539; 1316540; 1480178; 1303262; 1631125; 8213813; 8224266; 8103398; 8281139; 8281140; 8325932; 8325950; 8097257; 8096390; 8274409; 8446106; 8413310; 8145761; 7511268; 8292051; 8187068; 7910529; 7909256; 8205256; 8033918; 8162033; 7981687; 7981689; 8126121; 7962294; 8040309; 7929841; 7993455; 7970939; 8830623; 7712463; 7641413; 7671849; 7633398; 7537149; 7581399; 7591265; 7673412; 8530589; 7649358; 7723794; 8723113; 9816170; 9039340; 9001799; 8824883; 8550758; 8626869; 8768864; 8823308; 8918984; 8683794; 8647313; 8809734; 8628719; 8827083; 9106550; 9000575; 9196614; 9160185; 9007482; 8990010; 9438000; 9184448; 9255042; 9329414; 9252933; 9328206; 9302173; 9544375; 9698822; 9788719; 9610419; 9856504; 9554754; 9554755; 9543136; 9768671; 9851768; 9627582; 9607727; 10470409; 10363963; 10502786; 10571951; 10221692; 10404311; 10022458; 10629558; 10569618; 10543676; 10221770; 10598582; 10590024; 10458483; 10092153; 10706109; 10690872; 11587068; 11744994

# Macromolecular_Interacting_Partner_6_References:
10701889; 12007895; 16759873

# Macromolecular_Interacting_Partner_7_ID:
7623

# Macromolecular_Interacting_Partner_7_Name:
Insulin-like growth factor-binding protein 3 precursor

# Macromolecular_Interacting_Partner_7_Synonyms:
IGFBP-3; IBP- 3; IGF-binding protein 3

# Macromolecular_Interacting_Partner_7_Gene_Name:
IGFBP3

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Insulinlike growth factorbinding protein 3 precursor
MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAE
LVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAV
SRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHA
KDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNC
DKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
291

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
31674

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
8.78

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  growth factor binding
Function:  insulin-like growth factor binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of growth
Process:  regulation of cell growth
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00219:IGFBP;
PF00086:Thyroglobulin_1

# Macromolecular_Interacting_Partner_7_Signals:
1-27

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
183116

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
IBP3_HUMAN (P17936)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
IGFBP3

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
IGFBP3

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:5472

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>876 bp
ATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGCTGGTGCTGCTCCGC
GGGCCGCCGGTGGCGCGGGCTGGCGCGAGCTCGGGGGGCTTGGGTCCCGTGGTGCGCTGC
GAGCCGTGCGACGCGCGTGCACTGGCCCAGTGCGCGCCTCCGCCCGCCGTGTGCGCGGAG
CTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGAGCGAGGGCCAGCCG
TGCGGCATCTACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAG
GCGCGACCGCTGCAGGCGCTGCTGGACGGCCGCGGGCTCTGCGTCAACGCTAGTGCCGTC
AGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGAAATGCTAGTGAGTCG
GAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTG
TCTGATCCCAAGTTCCACCCCCTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCT
AAAGACAGCCAGCGCTACAAAGTTGACTACGAGTCTCAGAGCACAGATACCCAGAACTTC
TCCTCCGAGTCCAAGCGGGAGACAGAATATGGTCCCTGCCGTAGAGAAATGGAAGACACA
CTGAATCACCTGAAGTTCCTCAATGTGCTGAGTCCCAGGGGTGTACACATTCCCAACTGT
GACAAGAAGGGATTTTATAAGAAAAAGCAGTGTCGCCCTTCCAAAGGCAGGAAGCGGGGC
TTCTGCTGGTGTGTGGATAAGTATGGGCAGCCTCTCCCAGGCTACACCACCAAGGGGAAG
GAGGACGTGCACTGCTACAGCATGCAGAGCAAGTAG

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
M31159

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_7_Locus:
7p13-p12

# Macromolecular_Interacting_Partner_7_SNPs:
rs9282734; rs2854746; rs6950868; rs6670; rs2453840; rs2453839; rs34505796; rs35496550; rs35751739; rs34460927; rs34835646; rs3110697; rs6413441; rs6950802; rs2854747; rs6953668; rs33979592; rs2471551; rs12540724; rs3793345; rs2453837; rs35890775; rs34508316; rs34678704; rs10255707; rs34091405; rs17847673; rs1800906; rs35052563; rs34876509; rs34463602; rs2854750; rs35440925; rs34672517; rs9282735; rs10282088; rs11765572; rs10252403; rs2132570; rs13223993; rs10238613; rs2132572; rs2132571; rs13241830; rs35709394; rs35258778; rs34087654; rs34122177; rs34480712; rs34077804; rs3763500; rs2854744; rs35712717; rs17847676; rs34257987; rs34239916; rs34663167; rs35925180; rs2471549; rs34735423; rs11537920; rs11537915; rs9911; rs11537916; rs11537919; rs1050566; rs34735308; rs11537917; rs35704214; rs34930524; rs35689043; rs2515697; rs2854749; rs34515169; rs34833729; rs17847674; rs2645039; rs34988007; rs3110696; rs35683959; rs5883949; rs34331516; rs34014638; rs2645038; rs34898986; rs35350851; rs2645037; rs13230567; rs35872082; rs34720178; rs2854751; rs34424795; rs2854748; rs35855621; rs35610649; rs11292609; rs34881353; rs34006338; rs4302754; rs34533777; rs34351332; rs35017224; rs2854745; rs34097876; rs34058026; rs34939676; rs35533791; rs35919935; rs2645036; rs35300175; rs11773396; rs10230447; rs12671457; rs12671484; rs12702181; rs2088300; rs2088301; rs2270628; rs2453836; rs2515696; rs885555; rs903889; rs924140

# Macromolecular_Interacting_Partner_7_General_References:
2464130; 1695633; 7508771; 12853948; 1697583; 14561895

# Macromolecular_Interacting_Partner_7_References:
14763914; 15021445; 15590985; 15941949

# Macromolecular_Interacting_Partner_8_ID:
7844

# Macromolecular_Interacting_Partner_8_Name:
Insulin-like growth factor IA precursor

# Macromolecular_Interacting_Partner_8_Synonyms:
IGF-IA; Somatomedin C; Mechano growth factor; MGF

# Macromolecular_Interacting_Partner_8_Gene_Name:
IGF1

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Insulinlike growth factor IA precursor
MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD
ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS
VRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
17026

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
9.40

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
Function:  neuropeptide hormone activity
Function:  prothoracicotrophic hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_8_Signals:
1-21

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
183110

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
IGF1A_HUMAN (P01343)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
IGF1

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
IGF1

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:5464

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>462 bp
ATGGGAAAAATCAGCAGTCTTCCAACCCAATTATTTAAGTGCTGCTTTTGTGATTTCTTG
AAGGTGAAGATGCACACCATGTCCTCCTCGCATCTCTTCTACCTGGCGCTGTGCCTGCTC
ACCTTCACCAGCTCTGCCACGGCTGGACCGGAGACGCTCTGCGGGGCTGAGCTGGTGGAT
GCTCTTCAGTTCGTGTGTGGAGACAGGGGCTTTTATTTCAACAAGCCCACAGGGTATGGC
TCCAGCAGTCGGAGGGCGCCTCAGACAGGCATCGTGGATGAGTGCTGCTTCCGGAGCTGT
GATCTAAGGAGGCTGGAGATGTATTGCGCACCCCTCAAGCCTGCCAAGTCAGCTCGCTCT
GTCCGTGCCCAGCGCCACACCGACATGCCCAAGACCCAGAAGGAAGTACATTTGAAGAAC
GCAAGTAGAGGGAGTGCAGGAAACAAGAACTACAGGATGTAG

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
M14156

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_8_Locus:
12q22-q23

# Macromolecular_Interacting_Partner_8_SNPs:
rs17884626; rs3729846; rs6220; rs6219; rs5742714; rs6214; rs6216; rs5742707; rs6217; rs6222; rs3730192; rs3730205; rs5742711; rs3730204; rs5742705; rs6221; rs5742713; rs5742715; rs3730189; rs5742706; rs1063599; rs6218; rs5742700; rs6215; rs35528193; rs17881987; rs3209674; rs6212; rs3730201; rs3730190; rs5742704; rs1140655; rs17879349; rs5031032; rs978458; rs2373721; rs1019731; rs2195240; rs2288378; rs2195239; rs5742629; rs11111274; rs5742657; rs2033178; rs7314527; rs10860869; rs4764696; rs10778176; rs9989002; rs4764883; rs12310428; rs5009837; rs5742659; rs9308315; rs972936; rs5742683; rs4764886; rs10735380; rs4764887; rs7136446; rs5742632; rs7956547; rs5742692; rs17727519; rs6213; rs17880975; rs17882264; rs10047577; rs2072592; rs17879892; rs5742627; rs5742634; rs6539035; rs10860865; rs5742694; rs17032565; rs5742620; rs5742644; rs12821878; rs11831436; rs7957559; rs5742696; rs10745942; rs17032634; rs5742682; rs1520221; rs17727841; rs11829586; rs1549593; rs2195242; rs10860867; rs9651925; rs17884734; rs17884998; rs5742658; rs4764698; rs11111265; rs5742665; rs11831702; rs12305089; rs12423791; rs5742614; rs5742639; rs5742643; rs5742690; rs17885092; rs12299353; rs2162679; rs5742695; rs5742653; rs5742623; rs17032623; rs5742615; rs11837195; rs11111272; rs5742668; rs5742626; rs5742624; rs5742678; rs5742637; rs11111267; rs1520220; rs7132915; rs5742667; rs5742652; rs5742669; rs5742618; rs10778174; rs4764697; rs28682289; rs5742671; rs11111266; rs4764699; rs5742655; rs5742638; rs10778175; rs5742666; rs5742617; rs5742663; rs12833855; rs5742689; rs5742622; rs17885209; rs7300373; rs5742654; rs5742645; rs7971494; rs5742636; rs10745940; rs17796225; rs5742661; rs35996361; rs17886202; rs5742656; rs5742686; rs5742670; rs2373722; rs35524121; rs17882461; rs11111269; rs35626892; rs11111262; rs5742647; rs10860864; rs17882373; rs5742664; rs12313279; rs17884900; rs5742625; rs17878658; rs7296464; rs17879380; rs12426645; rs5742635; rs5742688; rs5742628; rs6539036; rs5742672; rs34300540; rs5742649; rs4764885; rs35897406; rs35349902; rs35209973; rs5742630; rs17882108; rs17878845; rs17885477; rs1520222; rs17886416; rs17881922; rs35437018; rs17879867; rs12316064; rs5742633; rs34291100; rs34311929; rs5742660; rs5742641; rs17878318; rs5742648; rs17884646; rs11608757; rs5742621; rs5742684; rs12425939; rs4764884; rs10860866; rs17032577; rs17878342; rs35767; rs5742722; rs5742723; rs2946834; rs11829707; rs5742720; rs5742612; rs11829693; rs2288377; rs5742716; rs3730195; rs3730193; rs35365615; rs5742702; rs3730211; rs3730224; rs5742712; rs3730210; rs4479044; rs3730207; rs5800508; rs34632512; rs17884961; rs5742698; rs3730206; rs3730203; rs35306040; rs35234844; rs3730188; rs3730226; rs17885397; rs5742703; rs5742701; rs2114911; rs3730218; rs5742708; rs3730221; rs28399924; rs35770817; rs1142050; rs3730200; rs35042457; rs1063600; rs14970; rs34621369; rs5742709; rs3032446; rs3730209; rs3730191; rs5742613; rs3730223; rs17847185; rs5742710; rs3730212; rs3730208; rs17847188; rs35359199; rs5800507; rs17886337; rs35249557; rs12817059; rs9282710; rs34903472; rs5742693; rs12299690; rs34647656; rs5742675; rs12810139; rs10745941; rs2373723; rs17879585; rs17880891; rs12320356; rs35140968; rs5800510; rs17879693; rs17882696; rs35437431; rs35174508; rs5742687; rs17885230; rs11608743; rs12368271; rs17882221; rs2373724; rs17886520; rs35775928; rs5742619; rs10860863; rs17885564; rs5742676; rs5742677; rs11421600; rs34805296; rs12816379; rs11608742; rs11111273; rs17879010; rs17886798; rs17882149; rs34599859; rs12817072; rs3032454; rs34813772; rs10860868; rs17879390; rs11111268; rs17885210; rs9282711; rs17886237; rs35222135; rs17878871; rs3729847; rs10557735; rs12320358; rs12819048; rs17878637; rs34545292; rs17882016; rs17878716; rs10614489; rs34568432; rs5742650; rs11111279; rs17881804; rs17878620; rs5742616; rs35813377; rs35403470; rs5742640; rs5742673; rs35865277; rs17879664; rs10685119; rs5742680; rs11111263; rs12314338; rs17878397; rs11111271; rs17880004; rs5742681; rs5742646; rs35004383; rs11111278; rs34817710; rs36103805; rs11111270; rs5742651; rs17881582; rs17885105; rs12816545; rs17882697; rs5742674; rs35123842; rs10161018; rs17882126; rs35993329; rs5742697; rs764911; rs11111277; rs35635523; rs12809983; rs5742631; rs1015693; rs17878818; rs12370356; rs11111276; rs35660465; rs7297946; rs11111281; rs11305762; rs34097393; rs34199594; rs5742662; rs17881697; rs36047405; rs36123817; rs4764882; rs17878303; rs36005419; rs17886265; rs17728444; rs12319588; rs17884880; rs34918171; rs11111264; rs35433913; rs5800512; rs17885262; rs17879785; rs17879563; rs17883650; rs34618338; rs34085295; rs34241965; rs17883689; rs34212937; rs17882244; rs17887104; rs34938746; rs35261849; rs12816586; rs17885578; rs17882564; rs17884984; rs17879080; rs17879837; rs12820619; rs11111280; rs12229818; rs17885158; rs5742691; rs34800889; rs12821533; rs11837097; rs5742679; rs17882237; rs12301183; rs34432139; rs17886964; rs34588740; rs5742685; rs10542027; rs35407198; rs5742642; rs17882333; rs10592539; rs5800511; rs17885342; rs35384466; rs3033405; rs12830260; rs2217241; rs3033407; rs17879774; rs35806302; rs17882374; rs5742717; rs10665874; rs5742719; rs5800513; rs7487728; rs5742718; rs17884864; rs5742721; rs10860860; rs10860861; rs10860862; rs11111259; rs11111260; rs11111261; rs11111282; rs11831864; rs12301163; rs12301559; rs12579077; rs12579108; rs1457601; rs17032483; rs17032487; rs17032648; rs2373720; rs2946831; rs2971575; rs2971577; rs35765; rs35766; rs7316439; rs7980083; rs855201; rs9919733

# Macromolecular_Interacting_Partner_8_General_References:
2937782; 6358902; 2935423; 3002851; 2018498; 1372070; 6382022; 632300; 6189745; 2036417; 1319992; 3242681; 8857020

# Macromolecular_Interacting_Partner_8_References:
14667889; 15021445; 16381008

# Macromolecular_Interacting_Partner_9_ID:
7973

# Macromolecular_Interacting_Partner_9_Name:
Inhibin beta A chain precursor

# Macromolecular_Interacting_Partner_9_Synonyms:
Activin beta-A chain; Erythroid differentiation protein; EDF

# Macromolecular_Interacting_Partner_9_Gene_Name:
INHBA

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Inhibin beta A chain precursor
MPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKK
HILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQT
SEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQK
HPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGKSSLDV
RIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQS
EDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAG
TSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIV
EECGCS

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
426

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
47443

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
8.10

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  growth factor activity
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  growth
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00019:TGF_beta;
PF00688:TGFb_propeptide

# Macromolecular_Interacting_Partner_9_Signals:
1-20

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
307069

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
INHBA_HUMAN (P08476)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
INHBA

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
INHBA

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:6066

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>1281 bp
ATGCCCTTGCTTTGGCTGAGAGGATTTCTGTTGGCAAGTTGCTGGATTATAGTGAGGAGT
TCCCCCACCCCAGGATCCGAGGGGCACAGCGCGGCCCCCGACTGTCCGTCCTGTGCGCTG
GCCGCCCTCCCAAAGGATGTACCCAACTCTCAGCCAGAGATGGTGGAGGCCGTCAAGAAG
CACATTTTAAACATGCTGCACTTGAAGAAGAGACCCGATGTCACCCAGCCGGTACCCAAG
GCGGCGCTTCTGAACGCGATCAGAAAGCTTCATGTGGGCAAAGTCGGGGAGAACGGGTAT
GTGGAGATAGAGGATGACATTGGAAGGAGGGCAGAAATGAATGAACTTATGGAGCAGACC
TCGGAGATCATCACGTTTGCCGAGTCAGGAACAGCCAGGAAGACGCTGCACTTCGAGATT
TCCAAGGAAGGCAGTGACCTGTCAGTGGTGGAGCGTGCAGAAGTCTGGCTCTTCCTAAAA
GTCCCCAAGGCCAACAGGACCAGGACCAAAGTCACCATCCGCCTCTTCCAGCAGCAGAAG
CACCCGCAGGGCAGCTTGGACACAGGGGAAGAGGCCGAGGAAGTGGGCTTAAAGGGGGAG
AGGAGTGAACTGTTGCTCTCTGAAAAAGTAGTAGACGCTCGGAAGAGCACCTGGCATGTC
TTCCCTGTCTCCAGCAGCATCCAGCGGTTGCTGGACCAGGGCAAGAGCTCCCTGGACGTT
CGGATTGCCTGTGAGCAGTGCCAGGAGAGTGGCGCCAGCTTGGTTCTCCTGGGCAAGAAG
AAGAAGAAAGAAGAGGAGGGGGAAGGGAAAAAGAAGGGCGGAGGTGAAGGTGGGGCAGGA
GCAGATGAGGAAAAGGAGCAGTCGCACAGACCTTTCCTCATGCTGCAGGCCCGGCAGTCT
GAAGACCACCCTCATCGCCGGCGTCGGCGGGGCTTGGAGTGTGATGGCAAGGTCAACATC
TGCTGTAAGAAACAGTTCTTTGTCAGTTTCAAGGACATCGGCTGGAATGACTGGATCATT
GCTCCCTCTGGCTATCATGCCAACTACTGCGAGGGTGAGTGCCCGAGCCATATAGCAGGC
ACGTCCGGGTCCTCACTGTCCTTCCACTCAACAGTCATCAACCACTACCGCATGCGGGGC
CATAGCCCCTTTGCCAACCTCAAATCGTGCTGTGTGCCCACCAAGCTGAGACCCATGTCC
ATGTTGTACTATGATGATGGTCAAAACATCATCAAAAAGGACATTCAGAACATGATCGTG
GAGGAGTGTGGGTGCTCATAG

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
M13436

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_9_Locus:
7p15-p13

# Macromolecular_Interacting_Partner_9_SNPs:
rs41294833; rs2237436; rs2237435; rs2237432; rs3801158; rs11770488; rs2282921; rs6958234; rs2237434; rs2877098; rs35168740; rs35118590; rs35239129; rs10263517; rs13230382; rs35784619; rs35446171; rs3030163; rs34094470; rs2330258; rs33937463; rs34410146; rs35954856; rs35515062; rs11388094; rs2237433; rs3030167; rs35205139; rs36006177; rs34883301; rs28536672; rs6961410; rs34617847; rs35332768; rs1003291; rs10261223; rs1046634; rs10486719; rs1122291; rs11522987; rs11772989; rs12333333; rs12333401; rs12532252; rs12701929; rs12701930; rs17705333; rs2007475; rs3735360; rs6977571; rs998190

# Macromolecular_Interacting_Partner_9_General_References:
3754442; 3267209; 1777673; 12853948; 3758355; 12660162

# Macromolecular_Interacting_Partner_9_References:
10775170; 11232020; 14668202

# Macromolecular_Interacting_Partner_10_ID:
8081

# Macromolecular_Interacting_Partner_10_Name:
Leptin precursor

# Macromolecular_Interacting_Partner_10_Synonyms:
Obesity factor; Obese protein

# Macromolecular_Interacting_Partner_10_Gene_Name:
LEP

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Leptin precursor
MHWGTLCGFLWLWPYLFYVQAVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGL
DFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLP
WASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
167

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
18641

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
6.34

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF02024:Leptin

# Macromolecular_Interacting_Partner_10_Signals:
1-21

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
623332

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
LEP_HUMAN (P41159)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
LEP

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
LEP

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:6553

# Macromolecular_Interacting_Partner_10_PDB_ID:
1AX8

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>504 bp
ATGCATTGGGGAACCCTGTGCGGATTCTTGTGGCTTTGGCCCTATCTTTTCTATGTCCAA
GCTGTGCCCATCCAAAAAGTCCAAGATGACACCAAAACCCTCATCAAGACAATTGTCACC
AGGATCAATGACATTTCACACACGCAGTCAGTCTCCTCCAAACAGAAAGTCACCGGTTTG
GACTTCATTCCTGGGCTCCACCCCATCCTGACCTTATCCAAGATGGACCAGACACTGGCA
GTCTACCAACAGATCCTCACCAGTATGCCTTCCAGAAACGTGATCCAAATATCCAACGAC
CTGGAGAACCTCCGGGATCTTCTTCACGTGCTGGCCTTCTCTAAGAGCTGCCACTTGCCC
TGGGCCAGTGGCCTGGAGACCTTGGACAGCCTGGGGGGTGTCCTGGAAGCTTCAGGCTAC
TCCACAGAGGTGGTGGCCCTGAGCAGGCTGCAGGGGTCTCTGCAGGACATGCTGTGGCAG
CTGGACCTCAGCCCTGGGTGCTGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
U18915

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_10_Locus:
7q31.3

# Macromolecular_Interacting_Partner_10_SNPs:
rs17151919; rs13306517; rs28954113; rs11763517; rs4731426; rs10954173; rs11761556; rs4731427; rs2167270; rs7791621; rs10257175; rs12706832; rs11760956; rs7795794; rs28954116; rs11978419; rs10244329; rs17151922; rs2278814; rs28959471; rs10954174; rs4236625; rs7796202; rs28954117; rs28959470; rs28954095; rs28954101; rs28954086; rs28954099; rs28959468; rs3750034; rs28954093; rs2278815; rs2122627; rs28954379; rs28959474; rs28954082; rs41457646; rs28954114; rs28954096; rs28959476; rs28954084; rs28954102; rs28954100; rs2060713; rs28954090; rs28954098; rs28954105; rs28954118; rs11980266; rs28954091; rs12706831; rs28959475; rs28954094; rs28954083; rs28756049; rs11973652; rs3793162; rs17151913; rs17151914; rs6956510; rs2071045; rs3828942; rs7788818; rs10264361; rs28954109; rs28954110; rs28954108; rs28954111; rs791616; rs28954376; rs28954081; rs6976701; rs10262600; rs28954369; rs28954080; rs28954371; rs34104384; rs4728096; rs791620; rs28954372; rs28954373; rs28954375; rs35048003; rs28959478; rs10258300; rs12536535; rs28954378; rs13228377; rs1800564; rs1800583; rs28954097; rs11380467; rs35394014; rs28959469; rs10676401; rs28954106; rs1031340; rs28954115; rs1349398; rs34219283; rs28959472; rs28954088; rs10243710; rs6966536; rs28954104; rs10620014; rs34457895; rs13306516; rs33910507; rs28954107; rs41526944; rs41434248; rs28954087; rs34728887; rs28954103; rs28959473; rs41528456; rs17617757; rs28954089; rs28954092; rs34052732; rs10277407; rs28954112; rs41474844; rs13306518; rs35447711; rs34046133; rs36212573; rs28959477; rs36219262; rs791618; rs28954370; rs791619; rs34669250; rs10598051; rs28954377; rs36219261; rs28391558; rs791617; rs28954374; rs36219260; rs10249476; rs10264838; rs10276311; rs10487506; rs10954175; rs10954176; rs11770725; rs12535708; rs12535747; rs12537573; rs13245201; rs1349419; rs1376268; rs16871960; rs17151895; rs2060715; rs2167271; rs35854831; rs4731423; rs4731424; rs4731428; rs4731429; rs4731430; rs6949498; rs712722; rs7778154; rs7782257; rs7798338; rs7799039; rs7801674; rs7802530; rs791604; rs791606; rs791607; rs791608; rs791610; rs791611; rs791612; rs791613; rs791614; rs791615

# Macromolecular_Interacting_Partner_10_General_References:
7984236; 7789654; 8626726; 7499240; 8621021; 10428856; 9166907; 9144295; 9500540

# Macromolecular_Interacting_Partner_10_References:
10076188; 10537117; 10965205; 11502810

End of HMDB00053

Beginning of HMDB00054
# Accession_No:
HMDB00054

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-25 16:36:57

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Bilirubin

# Description:
A bile pigment that is a degradation product of HEME. -- Pubchem; Bilirubin is a yellow breakdown product of normal heme catabolism. Its levels are elevated in certain diseases and it is responsible for the yellow color of bruises. Bilirubin is an excretion product, and the body does not control levels. Bilirubin levels reflect the balance between production and excretion. Thus, there is no "normal" level of bilirubin. Bilirubin consists of an open chain of four pyrroles (tetrapyrrole); by contrast, the heme molecule is a ring of four pyrroles, called porphyrin. -- Wikipedia

# Synonyms:
(4Z,15Z)-Bilirubin IXa; (Z,Z)-Bilirubin IXa; 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionate; 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionic acid; 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8,12-dipropanoate; 3-(2-((3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-1H-pyrrol-2-yl)methyl)-4-methyl-5-[(Z)-(4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene; 3-(2-((3-(2-carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoate; 3-[2-[[3-(2-carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate;  3-[2-[[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate; Bilirubin; Bilirubin IX-alpha; Cholerythrin; Hematoidin 

# Chemical_IUPAC_Name:
3-[2-[[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid

# Chemical_Formula:
C33H36N4O6

# Chemical_Structure:
tbl_chemical:::HMDB00054_ZOOM.png:::119283160047923892

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00054_THUMB.png:::119283159823284225

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Tetrapyrroles; Porphyrins

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
enamine; carboxylic acid; oxo(het)arene; alkene; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of Porphyrin and chlorophyll metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
584.26349

# Molecular_Weight_Avg:
584.66217

# Smiles_String_isomeric:
CC1=C(C=C)C(NC1=O)=CC2=C(C)C(CCC(O)=O)=C(CC3=C(CCC(O)=O)C(C)=C(N3)C=C4/NC(=O)C(C=C)=C4C)N2

# Smiles_String_canonical:
CC1=C(C=C)C(NC1=O)=CC2=C(C)C(CCC(O)=O)=C(CC3=C(CCC(O)=O)C(C)=C(N3)C=C4NC(=O)C(C=C)=C4C)N2

# KEGG_Compound_ID:
C00486

# BioCyc_ID:
BILIRUBIN

# PubChem_CID:
5280352

# PubChem_SID:
8144728; 8616233; 10319019; 10474149; 11537670; 10687731; 155796

# OMIM_ID:
Not Available

# Metagene_ID:
GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY. FAVISM: 149; PYRUVATE KINASE DEFICIENCY: 138; INTOXICATION ACETAMINOPHEN [DD]: 389; GLYCOGENOSIS, TYPE VII. TARUI DISEASE: 167; TRIHYDROXYCOPROSTANIC ACIDEMIA. COPROSTANIC ACIDEMIA: 20; PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS: 363; GALACTOSEMIA: 136; CRIGLER-NAJJAR SYNDROME TYPE II: 433; WILSON DISEASE: 178; CRIGLER-NAJJAR SYNDROME TYPE I: 432

# BiGG_ID:
35117

# Wikipedia_ID:
Bilirubin

# METLIN_ID:
81

# Ref_ID:
15858963; 2648917; 15245596; 15242029; 8903413; 15189696; 16100141; 12068294; 14761351; 15718382; 15173484; 16225094; 16163462; 15684703; 9262222; 16700327; 16440420; 15081641; 15249403; 15838745

# ChEBI_ID:
16990

# CAS_Registry_Number:
635-65-4

# InChI:
InChI=1/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-

# Synthesis_Reference:
Not Available

# Melting_Point:
Not Available

# Melting_Point_predicted:
179.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.009 mg/mL at 25 oC [BEILSTEIN]

# H2O_Solubility_Predicted:
9.64e-03 mg/mL [Predicted by ALOGPS]

# phys_charge:
-2

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
3.23 [Predicted by ALOGPS]; 1.945 [Predicted by PubChem via XLOGP]; 5.04 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Bilirubin.pdf:::1132562194340562996

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Bilirubin.mol:::1132723803906308575

# SDF_File_[Text]:
tbl_chemical:::HMDB00054.sdf:::119283159298774470

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00054.pdb:::11928315965041301

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Bilirubin.gif:::113273210326579170

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00054_peaks.txt:::1156309514237430094

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Bilirubin_C.gif:::1132737668914324871

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00054_peaks.txt:::1156310704725388124

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane (Predicted from LogP); Cytoplasm; endoplasmic reticulum; Extracellular

# Tissue_Location:
Bile Duct; Bone Marrow; Brain; Erythrocyte; Fibroblasts; Intestine; Kidney; Liver; Liver Predominantly; Lymph Node; Muscle; Myelin; Nerves; Neurons; Pancreas; Placenta; Platelet; Reticulocyte; Skin; Spleen; Thyroid Gland

# deuterated:
No

# Biofluid_Location:
Bile; Blood; CSF; Urine

# Concentration_[Normal]:
Urine	< 0.1	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Tietz Clinical Guide to Laboratory Tests 4th Ed., 2006.
Blood	13.0 (5.0-21.0)	umol/L	Adult:>18_yrs_old	Both	Normal	Tietz Clinical Guide to Laboratory Tests 4th Ed., 2006.
Blood	3400.0 +/- 11900.0	umol/L	Adult:>18_yrs_old	Both	Normal	Wikipedia
Cerebrospinal_Fluid(CSF)	0 - 0.2	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.


# Concentration_[Abnormal]:
Cerebrospinal_Fluid(CSF)	17.3 +/- 12.4	uM	Adult:>18_yrs_old	Both	Patients with cerebral vasospasm after subarachnoid hemorrhage	15789034 
Bile	5000 (4300-5700)	uM	Adult:>18_yrs_old	Both	Crohn's disease	16440420
Bile	2600 (2400-2800)	umol/L	Adult:>18_yrs_old	Both	Gallstone disease	16440420
Bile	4600 (3900-5300)	umol/L	Adult:>18_yrs_old	Both	Crohn's disease	16440420
Bile	5900 (4300-7500)	umol/L	Adult:>18_yrs_old	Both	Crohn's disease	16440420


# Associated_Disorders:
Colorectal Cancer; Coprostanic Acidemia; Crigler-Najjar Syndrome, Types I and II; Crohn's disease; Galactosemia; Gallstone disease; Glucose-6-Phosphate Dehydrogenase Deficiency (Favism); Glycogenosis, Type VII; Hyperbilirubinemia; Icterus; Intoxication Acetaminophen [DD]; Patients with cerebral vasospasm after subarachnoid hemorrhage; Progressive Familial Intrahepatic Cholestasis; Pyruvate Kinase Deficiency; Tarui Disease; Trihydroxycoprostanic Acidemia; Wilson Disease

# Pathway_Names:
Pentose and glucuronate interconversions;Androgen and estrogen metabolism;Starch and sucrose metabolism;Porphyrin and chlorophyll metabolism

# Pathway_Images:
;;;

# KEGG_Images:
map00040;map00150;map00500;map00860

# Pathway_Graphs:
;;;

# Pathway_SBMLs:
;;;

# Metabolic_Enzyme_1_ID:
5725

# Metabolic_Enzyme_1_Name:
UDP-glucuronosyltransferase 1-1 precursor

# Metabolic_Enzyme_1_Synonyms:
UDP- glucuronosyltransferase 1A1; UDPGT; UGT1*1; UGT1-01; UGT1.1; UGT- 1A; UGT1A; Bilirubin-specific UDPGT isozyme 1; HUG-BR1

# Metabolic_Enzyme_1_Gene_Name:
UGT1A1

# Metabolic_Enzyme_1_Protein_Sequence:
>UDPglucuronosyltransferase 11 precursor
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_1_Number_of_Residues:
533

# Metabolic_Enzyme_1_Molecular_Weight:
59592

# Metabolic_Enzyme_1_Theoretical_pI:
8.09

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

# Metabolic_Enzyme_1_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_1_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_1_Signals:
1-25

# Metabolic_Enzyme_1_Transmembrane_Regions:
491-507

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_1_GenBank_ID_Protein:
184473

# Metabolic_Enzyme_1_SwissProt_ID:
UD11_HUMAN (P22309)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
UGT1A1

# Metabolic_Enzyme_1_Geneatlas_id:
UGT1A1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:12530

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Microsome

# Metabolic_Enzyme_1_Gene_Sequence:
>1602 bp
ATGGCTGTGGAGTCCCAGGGCGGACGCCCACTTGTCCTGGGCCTGCTGCTGTGTGTGCTG
GGCCCAGTGGTGTCCCATGCTGGGAAGATACTGTTGATCCCAGTGGATGGCAGCCACTGG
CTGAGCATGCTTGGGGCCATCCAGCAGCTGCAGCAGAGGGGACATGAAATAGTTGTCCTA
GCACCTGACGCCTCGTTGTACATCAGAGACGGAGCATTTTACACCTTGAAGACGTACCCT
GTGCCATTCCAAAGGGAGGATGTGAAAGAGTCTTTTGTTAGTCTCGGGCATAATGTTTTT
GAGAATGATTCTTTCCTGCAGCGTGTGATCAAAACATACAAGAAAATAAAAAAGGACTCT
GCTATGCTTTTGTCTGGCTGTTCCCACTTACTGCACAACAAGGAGCTCATGGCCTCCCTG
GCAGAAAGCAGCTTTGATGTCATGCTGACGGACCCTTTCCTTCCTTGCAGCCCCATCGTG
GCCCAGTACCTGTCTCTGCCCACTGTATTCTTCTTGCATGCACTGCCATGCAGCCTGGAA
TTTGAGGCTACCCAGTGCCCCAACCCATTCTCCTACGTGCCCAGGCCTCTCTCCTCTCAT
TCAGATCACATGACCTTCCTGCAGCGGGTGAAGAACATGCTCATTGCCTTTTCACAGAAC
TTTCTGTGCGACGTGGTTTATTCCCCGTATGCAACCCTTGCCTCAGAATTCCTTCAGAGA
GAGGTGACTGTCCAGGACCTATTGAGCTCTGCATCTGTCTGGCTGTTTAGAAGTGACTTT
GTGAAGGATTACCCTAGGCCCATCATGCCCAATATGGTTTTTGTTGGTGGAATCAACTGC
CTTCACCAAAATCCACTATCCCAGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACAT
GGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATG
GCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACC
CGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTG
CTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAA
AGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAAT
GCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCT
GAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATC
ATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTC
TGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGAC
CTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTG
ACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAA
AAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M57899

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_1_Locus:
2q37

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
1898728; 1339448; 11434514; 1634050; 8280139; 8276413; 8226884; 7989045; 7989595; 7715297; 9621515; 9627603

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5720

# Metabolic_Enzyme_2_Name:
UDP-glucuronosyltransferase 2B10 precursor

# Metabolic_Enzyme_2_Synonyms:
UDPGT

# Metabolic_Enzyme_2_Gene_Name:
UGT2B10

# Metabolic_Enzyme_2_Protein_Sequence:
>UDPglucuronosyltransferase 2B10 precursor
MALKWTTVLLIQLSFYFSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSAS
ILFDPNDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEILWAIND
IIRNFCKDVVSNKKLMKKLQESRFDIVFADAYLPCGELLAELFNIPFVYSHSFSPGYSFE
RHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWFQIFNMKKWDQFYSEVLG
RPTTLSETMRKADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGE
NGVVVFSLGSMVSNMTEERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQND
LLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMS
STDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAH
NLTWFQYHSLDVIGFLLACVATVLFIITKCCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_2_Number_of_Residues:
528

# Metabolic_Enzyme_2_Molecular_Weight:
60775

# Metabolic_Enzyme_2_Theoretical_pI:
9.40

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_2_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_2_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_2_Signals:
1-23

# Metabolic_Enzyme_2_Transmembrane_Regions:
492-512

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_2_GenBank_ID_Protein:
516150

# Metabolic_Enzyme_2_SwissProt_ID:
UDB10_HUMAN (P36537)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
UGT2B10

# Metabolic_Enzyme_2_Geneatlas_id:
UGT2B10

# Metabolic_Enzyme_2_hgnc_id:
HGNC:12544

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Microsome

# Metabolic_Enzyme_2_Gene_Sequence:
>1587 bp
ATGGCTCTGAAATGGACTACAGTTCTGCTGATACAACTCAGTTTTTACTTTAGCTCTGGG
AGTTGTGGAAAGGTGCTGGTATGGGCCGCAGAATACAGCCTTTGGATGAATATGAAGACA
ATCCTGAAAGAACTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCTTCC
ATTCTTTTTGATCCCAACGACTCATCCACTCTTAAACTTGAAGTTTATCCTACATCTTTA
ACTAAAACTGAATTTGAGAATATCATCATGCAATTGGTTAAGAGATTGTCAGAAATTCAA
AAAGATACATTTTGGTTACCTTTTTCACAAGAACAAGAAATCCTGTGGGCAATTAATGAC
ATAATTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAACTTATGAAAAAACTACAA
GAGTCAAGATTTGACATCGTTTTTGCAGATGCTTATTTACCCTGTGGTGAGCTGCTGGCT
GAGCTATTTAACATACCCTTTGTGTACAGTCACAGCTTCAGTCCTGGCTACTCATTTGAA
AGGCACAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAAAATTA
AGTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGCTCTATGTGCTTTATTTTGAC
TTTTGGTTCCAAATATTTAATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTAGGA
AGACCCACTACATTATCTGAGACAATGAGGAAAGCTGACATATGGCTTATGCGAAACTCC
TGGAATTTTAAATTTCCTCATCCATTCTTACCAAATGTTGATTTTGTTGGAGGACTCCAC
TGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAGTTTGTACAGAGCTCTGGAGAA
AATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGGGCC
AACGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTTTGGAGATTTGATGGG
AATAAACCAGATGCCTTAGGTCTCAATACTCGACTGTACAAGTGGATACCCCAGAATGAC
CTTCTAGGTCATCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATCTAT
GAGGCAATCTACCATGGGATCCCTATGGTGGGCATTCCATTGTTTTTTGATCAACCTGAT
AATATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGAGTGGACTTCAACACAATGTCG
AGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTCATATAAAGAGAAT
ATTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCAGTC
TTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCCAAACATCTTCGAGTTGCAGCCCAC
AACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGCTTGTGTG
GCAACCGTGCTATTTATCATCACAAAGTGTTGTCTGTTTTGTTTCTGGAAGTTTGCTAGA
AAAGGAAAGAAGGGAAAAAGGGATTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X63359

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_2_Locus:
4q13.2

# Metabolic_Enzyme_2_SNPs:
rs3208727; rs17146903; rs17146904; rs835313; rs835316; rs835309; rs861340; rs844342; rs1841042; rs294778; rs835311; rs2670431; rs294777; rs835317; rs7676529; rs835310; rs11726322; rs11249509; rs1968764; rs7676146; rs1849533; rs17146894; rs835314; rs294772; rs9917967; rs2054221; rs3792628; rs1849534; rs1913316; rs7657958; rs1913315; rs2926036; rs835312; rs1913317; rs4694343; rs835319; rs7673996; rs2670430; rs835315; rs4694344; rs1913318; rs7670334; rs1913320; rs11940320; rs294776; rs4694358; rs294775; rs1976666; rs4095564; rs9917968; rs2942857; rs4116824; rs3215212; rs28563143; rs1902931; rs13111730; rs12506094; rs1979281; rs11347207; rs34334121; rs12511664; rs5859144; rs5859145; rs13141448; rs4116823; rs28377589; rs35887929; rs36003814; rs34999460; rs7678703; rs9917930; rs35390620; rs1902932; rs7674011; rs6839369; rs10007687; rs4095563; rs5859146; rs1902930; rs13148664; rs33938096; rs13110924; rs5859147; rs7685333; rs28586884; rs10428371; rs294771; rs13132114; rs6839806; rs34291505; rs13131461; rs13132118; rs13114078; rs4116825; rs13111722; rs835318; rs17146905; rs34183546; rs35690388; rs11725502; rs35525464; rs11729424; rs11737566; rs11737644; rs1379809; rs1458232; rs1458233; rs294765; rs294770; rs4450999; rs4694340; rs6816491; rs6836993; rs6843220

# Metabolic_Enzyme_2_General_References:
8333863

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5727

# Metabolic_Enzyme_3_Name:
UDP-glucuronosyltransferase 1-8 precursor

# Metabolic_Enzyme_3_Synonyms:
UDP- glucuronosyltransferase 1A8; UDPGT; UGT1*8; UGT1-08; UGT1.8; UGT- 1H; UGT1H

# Metabolic_Enzyme_3_Gene_Name:
UGT1A8

# Metabolic_Enzyme_3_Protein_Sequence:
>UDPglucuronosyltransferase 18 precursor
MARTGWTSPIPLCVSLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLGKSLNCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLF
FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDACGLIVAKYFSLPSVVFARGIACHYLEEG
AQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLFCQYFSKNALEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_3_Number_of_Residues:
530

# Metabolic_Enzyme_3_Molecular_Weight:
59742

# Metabolic_Enzyme_3_Theoretical_pI:
7.73

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_3_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_3_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_3_Signals:
1-25

# Metabolic_Enzyme_3_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_3_GenBank_ID_Protein:
2613044

# Metabolic_Enzyme_3_SwissProt_ID:
UD18_HUMAN (Q9HAW9)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
UGT1A8

# Metabolic_Enzyme_3_Geneatlas_id:
UGT1A8

# Metabolic_Enzyme_3_hgnc_id:
HGNC:12540

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Microsome

# Metabolic_Enzyme_3_Gene_Sequence:
>1593 bp
ATGGCTCGCACAGGGTGGACCAGCCCCATTCCCCTATGTGTTTCTCTGCTGCTGACCTGT
GGCTTTGCTGAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGTCACTGGTTCACC
ATGCAGTCGGTGGTGGAGAAACTTATCCTCAGGGGGCATGAGGTGGTTGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGGAAAATCACTGAATTGCACAGTGAAGACTTACTCAACCTCA
TACACTCTGGAGGATCTGGACCGGGAATTCATGGATTTCGCCGATGCTCAATGGAAAGCA
CAAGTACGAAGTTTGTTTTCTCTATTTCTGAGTTCATCCAATGGTTTTTTTAACTTATTT
TTTTCGCATTGCAGGAGTTTGTTTAATGACCGAAGATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCGGTGTTTCTTGATCCTTTTGATGCCTGTGCGTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCGCCAGGGGAATAGGTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGAATTCTCTTAGGGTTCTCAGATGCC
ATGGCTTTCAAGGAGAGAGTACGGAACCACATCTTGCACTTGGAGGAACATTTATTTTGC
CAGTATTTTTCCAAAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACACCTGTCACA
GCATATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACAGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAATATGATCTTCATTGGTGGTATCAACTGCCATCAGGGA
AAGCCATTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
AF030310

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
9535849; 11434514; 12042666

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5741

# Metabolic_Enzyme_4_Name:
UDP-glucuronosyltransferase 1-7 precursor

# Metabolic_Enzyme_4_Synonyms:
UDP- glucuronosyltransferase 1A7; UDPGT; UGT1*7; UGT1-07; UGT1.7; UGT- 1G; UGT1G

# Metabolic_Enzyme_4_Gene_Name:
UGT1A7

# Metabolic_Enzyme_4_Protein_Sequence:
>UDPglucuronosyltransferase 17 precursor
MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLF
FSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEG
AQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_4_Number_of_Residues:
530

# Metabolic_Enzyme_4_Molecular_Weight:
59819

# Metabolic_Enzyme_4_Theoretical_pI:
7.85

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_4_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_4_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_4_Signals:
1-25

# Metabolic_Enzyme_4_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_4_GenBank_ID_Protein:
2039360

# Metabolic_Enzyme_4_SwissProt_ID:
UD17_HUMAN (Q9HAW7)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
UGT1A7

# Metabolic_Enzyme_4_Geneatlas_id:
UGT1A7

# Metabolic_Enzyme_4_hgnc_id:
HGNC:12539

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Microsome

# Metabolic_Enzyme_4_Gene_Sequence:
>1593 bp
ATGGCTCGTGCAGGGTGGACTGGCCTCCTTCCCCTATATGTGTGTCTACTGCTGACCTGT
GGCTTTGCCAAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGCCACTGGTTCACC
ATGCAGTCGGTGGTGGAGAAACTCATCCTCAGGGGGCATGAGGTGGTCGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGGAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCA
TACACTCTGGAGGATCAGGACCGGGAGTTCATGGTTTTTGCCGATGCTCGCTGGACGGCA
CCATTGCGAAGTGCATTTTCTCTATTAACAAGTTCATCCAATGGTATTTTTGACTTATTT
TTTTCAAATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGT
TGTTTTGATGCAGTGTTTCTCGATCCTTTTGATGCCTGTGGCTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCGCCAGGGGAATATTTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGACTTCTCTTAGGGTTCTCAGACGCC
ATGACTTTCAAGGAGAGAGTATGGAACCACATCATGCACTTGGAGGAACATTTATTTTGC
CCCTATTTTTTCAAAAATGTCTTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACTGACTTTGTTTTGGAG
TATCCCAAACCCGTGATGCCCAATATGATCTTCATTGGTGGTATCAACTGTCATCAGGGA
AAGCCAGTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGCTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTTCAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
U89507

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_4_Locus:
2q37

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
9271343; 11434514; 11037804

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5731

# Metabolic_Enzyme_5_Name:
UDP-glucuronosyltransferase 2B17 precursor

# Metabolic_Enzyme_5_Synonyms:
UDPGT; C19- steroid-specific UDP-glucuronosyltransferase

# Metabolic_Enzyme_5_Gene_Name:
UGT2B17

# Metabolic_Enzyme_5_Protein_Sequence:
>UDPglucuronosyltransferase 2B17 precursor
MSLKWMSVFLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSA
SILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEY
SDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYT
VEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEV
LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
MSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVA
AHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLFCFRKLAKTGKKKKRD

# Metabolic_Enzyme_5_Number_of_Residues:
530

# Metabolic_Enzyme_5_Molecular_Weight:
61096

# Metabolic_Enzyme_5_Theoretical_pI:
8.73

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3alpha,17beta-diol (3alpha-diol) > testosterone > androsterone (ADT)

# Metabolic_Enzyme_5_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_5_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_5_Signals:
1-23

# Metabolic_Enzyme_5_Transmembrane_Regions:
495-515

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_5_GenBank_ID_Protein:
3287473

# Metabolic_Enzyme_5_SwissProt_ID:
UDB17_HUMAN (O75795)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
UGT2B17

# Metabolic_Enzyme_5_Geneatlas_id:
UGT2B17

# Metabolic_Enzyme_5_hgnc_id:
HGNC:12547

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Microsome

# Metabolic_Enzyme_5_Gene_Sequence:
>1593 bp
ATGTCTCTGAAATGGATGTCAGTCTTTCTGCTGATGCAGCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATACAGCCATTGGATAAATATGAAG
ACAATCCTGGAAGAGCTTGTTCAGAGGGGTCATGAGGTGATTGTGTTGACATCTTCGGCT
TCTATTCTTGTCAATGCCAGTAAATCATCTGCTATTAAATTAGAAGTTTATCCTACATCT
TTAACTAAAAATGATTTGGAAGATTTTTTTATGAAAATGTTCGATAGATGGACATATAGT
ATTTCAAAAAATACATTTTGGTCATATTTTTCACAACTACAAGAATTGTGTTGGGAATAT
TCTGACTATAATATAAAGCTCTGTGAAGATGCAGTTTTGAACAAGAAACTTATGAGAAAA
CTACAAGAGTCAAAATTTGATGTCCTTCTGGCAGATGCCGTTAATCCCTGTGGTGAGCTG
CTGGCTGAACTACTTAACATACCCTTTCTGTACAGTCTCCGCTTCTCTGTTGGCTACACA
GTTGAGAAGAATGGTGGAGGATTTCTGTTCCCTCCTTCCTATGTACCTGTTGTTATGTCA
GAATTAAGTGATCAAATGATTTTCATGGAGAGGATAAAAAATATGATATATATGCTTTAT
TTTGACTTTTGGTTTCAAGCATATGATCTGAAGAAGTGGGACCAGTTTTATAGTGAAGTT
CTAGGAAGACCCACTACATTATTTGAGACAATGGGGAAAGCTGAAATGTGGCTCATTCGA
ACCTATTGGGATTTTGAATTTCCTCGCCCATTCTTACCAAATGTTGATTTTGTTGGAGGA
CTTCACTGTAAACCAGCCAAACCCTTGCCTAAGGAAATGGAAGAGTTTGTGCAGAGCTCT
GGAGAAAATGGTATTGTGGTGTTTTCTCTGGGGTCGATGATCAGTAACATGTCAGAAGAA
AGTGCCAACATGATTGCATCAGCCCTTGCCCAGATCCCACAAAAGGTTCTATGGAGATTT
GATGGCAAGAAGCCAAATACTTTAGGTTCCAATACTCGACTGTATAAGTGGTTACCCCAG
AATGACCTTCTTGGTCATCCCAAAACCAAAGCTTTTATAACTCATGGTGGAACCAATGGC
ATCTATGAGGCGATCTACCATGGGATCCCTATGGTGGGCATTCCCTTGTTTGCGGATCAA
CATGATAACATTGCTCACATGAAAGCCAAGGGAGCAGCCCTCAGTGTGGACATCAGGACC
ATGTCAAGTAGAGATTTGCTCAATGCATTGAAGTCAGTCATTAATGACCCTATCTATAAA
GAGAATATCATGAAATTATCAAGAATTCATCATGATCAACCGGTGAAGCCCCTGGATCGA
GCAGTCTTCTGGATTGAGTTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTCGCA
GCCCACAACCTCACCTGGATCCAGTACCACTCTTTGGATGTGATAGCATTCCTGCTGGCC
TGCGTGGCAACTATGATATTTATGATCACAAAATGTTGCCTGTTTTGTTTCCGAAAGCTT
GCCAAAACAGGAAAGAAGAAGAAAAGGGATTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U59209

# Metabolic_Enzyme_5_Chromosome_Location:
Not Available

# Metabolic_Enzyme_5_Locus:
Not Available

# Metabolic_Enzyme_5_SNPs:
Not Available

# Metabolic_Enzyme_5_General_References:
8798464; 9364925

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5724

# Metabolic_Enzyme_6_Name:
UDP-glucuronosyltransferase 2A1 precursor

# Metabolic_Enzyme_6_Synonyms:
Not Available

# Metabolic_Enzyme_6_Gene_Name:
UGT2A1

# Metabolic_Enzyme_6_Protein_Sequence:
>UDPglucuronosyltransferase 2A1 precursor
MLNNLLLFSLQISLIGTTLGGNVLIWPMEGSHWLNVKIIIDELIKKEHNVTVLVASGALF
ITPTSNPSLTFEIYKVPFGKERIEGVIKDFVSTWLENRPSPSTIWRFYQEMAKVIKDFHM
VSQEICDGVLKNQQLMAKLKKSKFEVLVSDPVFPCGDIVALKLGIPFMYSLRFSPASTVE
KHCGKVPYPPSYVPAVLSELTDQMSFTDRIRNFISYHLQDYMFETLWKSWDSYYSKALGR
PTTLCETMGKAEIWLIRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFIQSSGKN
GVVVFSLGSMVKNLTEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDL
LGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTS
VDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHD
LTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKFGKIGKKKKRE

# Metabolic_Enzyme_6_Number_of_Residues:
527

# Metabolic_Enzyme_6_Molecular_Weight:
59873

# Metabolic_Enzyme_6_Theoretical_pI:
9.29

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform is active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium

# Metabolic_Enzyme_6_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_6_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_6_Signals:
1-20

# Metabolic_Enzyme_6_Transmembrane_Regions:
491-507

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_6_GenBank_ID_Protein:
4753766

# Metabolic_Enzyme_6_SwissProt_ID:
UDA1_HUMAN (Q9Y4X1)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
UGT2A1

# Metabolic_Enzyme_6_Geneatlas_id:
UGT2A1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:12542

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Membrane

# Metabolic_Enzyme_6_Gene_Sequence:
>1584 bp
ATGTTAAACAACCTTCTGCTGTTCTCCCTTCAGATAAGTCTCATAGGAACCACTCTTGGT
GGGAATGTTTTGATTTGGCCAATGGAAGGTAGTCATTGGCTAAATGTTAAGATAATTATA
GATGAGCTCATTAAAAAGGAGCATAATGTGACTGTCCTAGTTGCCTCTGGTGCACTTTTC
ATCACACCAACCTCTAACCCATCTCTGACATTTGAAATATATAAGGTGCCCTTTGGCAAA
GAAAGAATAGAAGGAGTAATTAAGGACTTCGTTTCGACATGGCTGGAAAATAGACCATCT
CCTTCAACCATTTGGAGATTCTATCAGGAGATGGCCAAAGTAATCAAGGACTTCCACATG
GTGTCTCAGGAGATCTGTGATGGCGTTCTTAAAAACCAACAGCTGATGGCAAAGCTAAAG
AAAAGCAAGTTTGAAGTCCTGGTGTCTGATCCAGTATTTCCTTGTGGCGATATAGTAGCT
TTAAAACTTGGAATTCCATTTATGTACTCCTTGAGGTTTTCTCCAGCCTCAACAGTGGAA
AAGCACTGTGGGAAGGTACCATACCCTCCTTCCTATGTTCCTGCTGTTTTATCAGAACTC
ACCGACCAAATGTCTTTCACTGACAGAATAAGAAATTTCATCTCCTACCACCTACAGGAC
TACATGTTTGAAACTCTTTGGAAATCATGGGATTCATACTATAGTAAAGCTTTAGGAAGA
CCCACTACGTTATGTGAGACTATGGGGAAAGCTGAAATTTGGTTAATCCGAACATATTGG
GATTTTGAATTTCCTCGTCCATACTTACCTAATTTTGAGTTTGTTGGAGGATTGCACTGC
AAACCTGCCAAACCTTTACCTAAGGAAATGGAAGAATTTATCCAGAGCTCAGGTAAAAAT
GGTGTTGTGGTGTTTTCTCTGGGATCAATGGTCAAAAACCTTACAGAAGAAAAGGCCAAT
CTTATTGCCTCAGCCCTTGCCCAGATTCCACAGAAGGTTTTATGGAGATACAAAGGAAAG
AAACCAGCCACATTAGGAAACAATACTCAGCTCTTTGATTGGATACCCCAGAATGATCTT
CTTGGACATCCCAAAACCAAAGCTTTTATCACTCATGGTGGAACTAATGGGATCTACGAA
GCTATTTACCACGGAGTCCCTATGGTGGGAGTTCCCATGTTTGCTGATCAGCCTGATAAC
ATTGCTCACATGAAGGCCAAAGGAGCAGCTGTGGAAGTGAACCTAAACACAATGACAAGT
GTGGATTTGCTTAGCGCTTTGAGAACAGTCATTAATGAACCTTCTTATAAAGAGAATGCT
ATGAGGTTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTGGATCGAGCAGTCTTC
TGGATCGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTTCGGGTTGCAGCCCATGAC
CTCACCTGGTTCCAGTACCACTCTTTGGATGTAATTGGGTTCTTGCTGGTCTGTGTGACA
ACGGCTATATTTTTGGTCATACAATGTTGTTTGTTTTCCTGTCAAAAATTTGGTAAGATA
GGAAAGAAGAAAAAAAGAGAATAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AJ006054

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_6_Locus:
4q13

# Metabolic_Enzyme_6_SNPs:
rs4148301; rs4148304; rs2163659; rs7668703; rs1432329; rs1432332; rs7659937; rs7672805; rs979363; rs10000435; rs4148279; rs10028495; rs7656541; rs6835972; rs4148276; rs1432330; rs4148277; rs6600796; rs1821185; rs1432335; rs1432336; rs1319811; rs7671313; rs10903210; rs7689493; rs10013528; rs9992698; rs988671; rs6842466; rs6825253; rs4148291; rs11728546; rs2331685; rs2017370; rs4694225; rs6832424; rs6600793; rs1432324; rs1560605; rs2163658; rs4148308; rs4401516; rs6600794; rs988672; rs3775783; rs1036160; rs7655867; rs6854350; rs1835826; rs4148295; rs2288740; rs2288741; rs1438537; rs1432316; rs6853543; rs11249451; rs1158439; rs4148281; rs10001991; rs11946382; rs10518063; rs2033798; rs6600792; rs4048747; rs1432314; rs10033801; rs7676249; rs10026988; rs10028954; rs7662867; rs1432315; rs11249452; rs1835821; rs10006049; rs4148289; rs10011630; rs7662309; rs4148298; rs10021575; rs17147507; rs9999694; rs6846404; rs4694219; rs17147542; rs7692074; rs10023821; rs11933160; rs7662915; rs1967984; rs6855271; rs4148292; rs11249454; rs10033879; rs1432313; rs7685874; rs17147532; rs7665571; rs11736315; rs4473712; rs10023782; rs4694222; rs7670819; rs7699881; rs6824954; rs11936310; rs11936130; rs6600795; rs1432327; rs10011912; rs3822178; rs1835829; rs9999430; rs6848997; rs1835822; rs11942157; rs4148290; rs17674565; rs17674511; rs10004306; rs6811810; rs4148297; rs17618404; rs1583243; rs6858314; rs10012508; rs6832784; rs2217587; rs3775782; rs12507278; rs6855294; rs17147530; rs11731188; rs10009530; rs6824830; rs13129549; rs6831807; rs11736373; rs10006483; rs17618520; rs17680131; rs7680856; rs4148286; rs11931365; rs10023877; rs17618178; rs11722780; rs10027493; rs6826237; rs17147521; rs11249453; rs7688383; rs4148299; rs4148302; rs9997689; rs6814603; rs7681367; rs17674648; rs9917881; rs4148296; rs11721934; rs4148283; rs6849110; rs12501520; rs4148307; rs11736353; rs13120401; rs4550998; rs4148309; rs6839067; rs6852329; rs7670238; rs7668967; rs11946584; rs10022954; rs6832167; rs2010207; rs12500392; rs7690649; rs17617467; rs10013712; rs9993182; rs6846030; rs4148305; rs17618230; rs10026603; rs4694027; rs4148288; rs6831951; rs11730451; rs10005934; rs1897441; rs4395582; rs11729544; rs4148312; rs4280808; rs10518065; rs11929943; rs11929908; rs10033854; rs17147557; rs1550292; rs13134357; rs11939884; rs1432334; rs1432333; rs17619211; rs17681080; rs10471252; rs1347046; rs41292307; rs4148310; rs41292305; rs35926238; rs4148275; rs7674020; rs35816431; rs34251717; rs11438429; rs4148311; rs4694226; rs1368116; rs35378505; rs34607614; rs4148278; rs10649712; rs10682826; rs188964; rs11732515; rs192970; rs11725441; rs28448316; rs33924396; rs28798793; rs17147492; rs324309; rs28413749; rs17147503; rs17147534; rs28404221; rs6600791; rs28570072; rs33943659; rs34090224; rs35971542; rs11460578; rs33999522; rs11441625; rs11323266; rs35281757; rs7677083; rs28776197; rs28782228; rs35910775; rs10583998; rs12644575; rs1967983; rs34446108; rs34142192; rs28544323; rs4148294; rs35582043; rs189787; rs4148285; rs11931171; rs2033801; rs11319385; rs11279957; rs5859193; rs324313; rs4148282; rs33938194; rs7377236; rs34704021; rs36106673; rs28818211; rs28532778; rs34265777; rs4148303; rs13119853; rs36003863; rs1583242; rs34513233; rs985040; rs7686386; rs10691812; rs34650072; rs13112999; rs11721725; rs28759827; rs28726183; rs34028035; rs324310; rs4409023; rs4148320; rs13131759; rs33953975; rs17147520; rs36051343; rs35795947; rs7672793; rs36163528; rs34021488; rs11733854; rs11721681; rs7669007; rs13149874; rs4148322; rs36083211; rs34789624; rs35333044; rs28560222; rs7693686; rs34698455; rs4148306; rs7657761; rs34909158; rs5859194; rs34670944; rs35243459; rs34139484; rs35400584; rs28689093; rs188966; rs11946796; rs11947056; rs11733907; rs28568390; rs34647023; rs10010846; rs6813494; rs7698372; rs28716091; rs10023818; rs35302832; rs34810925; rs34370025; rs4148313; rs4148287; rs34213902; rs35487350; rs35071017; rs10569499; rs33913173; rs28522985; rs34858243; rs28556671; rs34208726; rs34396917; rs4148284; rs11728785; rs28560191; rs28513556; rs28508252; rs36191379; rs4148316; rs4148280; rs4148293; rs7668214; rs2877457; rs34817437; rs2116564; rs11940905; rs10017134; rs28528833; rs35101874; rs33976214; rs34975164; rs34590689; rs34452487; rs2043241; rs3074345; rs35227598; rs34012364; rs34002846; rs28744454; rs34078716; rs34062331; rs5859195; rs35000204; rs33992705; rs10031145; rs33924614; rs11937993; rs13115454; rs1347047; rs1432317; rs1835830; rs4333255; rs6810459; rs7671030; rs7671041; rs7674562; rs7694939; rs9329029; rs9996459

# Metabolic_Enzyme_6_General_References:
10359671

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5719

# Metabolic_Enzyme_7_Name:
UDP-glucuronosyltransferase 1-4 precursor

# Metabolic_Enzyme_7_Synonyms:
UDP- glucuronosyltransferase 1A4; UDPGT; UGT1*4; UGT1-04; UGT1.4; UGT- 1D; UGT1D; Bilirubin-specific UDPGT isozyme 2; HUG-BR2

# Metabolic_Enzyme_7_Gene_Name:
UGT1A4

# Metabolic_Enzyme_7_Protein_Sequence:
>UDPglucuronosyltransferase 14 precursor
MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVV
LTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNV
SLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDL
DFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQ
REVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_7_Number_of_Residues:
534

# Metabolic_Enzyme_7_Molecular_Weight:
60026

# Metabolic_Enzyme_7_Theoretical_pI:
8.68

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

# Metabolic_Enzyme_7_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_7_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_7_Signals:
1-28

# Metabolic_Enzyme_7_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_7_GenBank_ID_Protein:
340137

# Metabolic_Enzyme_7_SwissProt_ID:
UD14_HUMAN (P22310)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
UGT1A4

# Metabolic_Enzyme_7_Geneatlas_id:
UGT1A4

# Metabolic_Enzyme_7_hgnc_id:
HGNC:12536

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Microsome

# Metabolic_Enzyme_7_Gene_Sequence:
>867 bp
ATGGCCAGAGGACTCCAGGTTCCCCTGCCGCGGCTGGCCACAGGACTGCTGCTCCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCACTGATGGCAGCCCC
TGGCTCAGCATGCGGGAGGCCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCGGTGGTC
CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAAATTTTTCACCCTGACAGCCTAT
GCTGTTCCATGGACCCAGAAGGAATTTGATCGCGTTACGCTGGGCTACACTCAAGGGTTC
TTTGAAACAGAACATCTTCTGAAGAGATATTCTAGAAGTATGGCAATTATGAACAATGTA
TCTTTGGCCCTTCATAGGTGTTGTGTGGAGCTACTGCATAATGAGGCCCTGATCAGGCAC
CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGTGGGGCGGTG
CTGGCTAAGTACCTGTCGATTCCTGCTGTGTTTTTTTGGAGGTACATTCCATGTGACTTA
GACTTTAAGGGCACACAGTGTCCAAATCCTTCCTCCTATATTCCTAAGTTACTAACGACC
AATTCAGACCACATGACATTCCTGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACATTTGCCATACTTTTTCTGCCCCTTATGCAAGTCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATCTTGTCAGCTATGCATCCGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGACTACCCCAGGCCGATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACGGGAAGCCACTATCTCAG

# Metabolic_Enzyme_7_GenBank_ID_Gene:
M84128

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_7_Locus:
2q37

# Metabolic_Enzyme_7_SNPs:
Not Available

# Metabolic_Enzyme_7_General_References:
1898728; 1339448; 11434514; 1634050; 8280139; 8276413

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5726

# Metabolic_Enzyme_8_Name:
UDP-glucuronosyltransferase 1-9 precursor

# Metabolic_Enzyme_8_Synonyms:
UDP- glucuronosyltransferase 1A9; UDPGT; UGT1*9; UGT1-9; UGT1.9; UGT- 1I; UGT1I; lugP4

# Metabolic_Enzyme_8_Gene_Name:
UGT1A9

# Metabolic_Enzyme_8_Protein_Sequence:
>UDPglucuronosyltransferase 19 precursor
MACTGWTSPLPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMRSVVEKLILRGHEVVVVMP
EVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLF
FSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNCGLIVAKYFSLPSVVFARGILCHYLEEG
AQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLLCHRFFKNALEIASEILQTPVT
EYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_8_Number_of_Residues:
530

# Metabolic_Enzyme_8_Molecular_Weight:
59942

# Metabolic_Enzyme_8_Theoretical_pI:
7.96

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols

# Metabolic_Enzyme_8_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_8_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_8_Signals:
1-25

# Metabolic_Enzyme_8_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_8_GenBank_ID_Protein:
7690346

# Metabolic_Enzyme_8_SwissProt_ID:
UD19_HUMAN (O60656)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
UGT1A9

# Metabolic_Enzyme_8_Geneatlas_id:
UGT1A9

# Metabolic_Enzyme_8_hgnc_id:
HGNC:12541

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Microsome

# Metabolic_Enzyme_8_Gene_Sequence:
>1593 bp
ATGGCTTGCACAGGGTGGACCAGCCCCCTTCCTCTATGTGTGTGTCTGCTGCTGACCTGT
GGCTTTGCCGAGGCAGGGAAGCTAGTGGTAGTGCCCATGGATGGGAGCCACTGGTTCACC
ATGAGGTCGGTGGTGGAGAAACTCATTCTCAGGGGGCATGAGGTGGTTGTAGTCAGTGCC
AGAGGTGAGTTGGCAACTGGGAAGATCAATGAATTGCACAGTGAAGACTTATTCAACTTC
ATATACCTGGAGGATCTGGACCGGGAGTTCAAGGCTTTTGCCCATGCTCAATGGAAAGCA
CAAGTACGAAGTATATATTCTCTATTAATGGGTTCATACAATGACATTTTTGACTTATTT
TTTTCAAATTGCAGGAGTTTGTTTAAAGACAAAAAATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCAGTGTTTCTCGATCCTTTTGATAACTGTGGCTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCCGTGGTCTTCGCCAGGGGAATACTTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGAATTCTCTTAGGGTTCTCAGATGAC
ATGACTTTCAAGGAGAGAGTACGGAACCACATCATGCACTTGGAGGAACATTTATTATGC
CACCGTTTTTTCAAAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACACCTGTTACG
GAGTATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACGGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAACATGATCTTCATTGGTGGTATCAACTGCCATGAGAGG
AAAGCGTTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GGTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATGC
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCAGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCATGAATGTTCTGGAAATGACTTCTGAAGAATTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTTATGAGGCACAAGGGCGCGACACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGCCGTGCTGACAGTGGCC
TTCATCACCTGTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
S55985

# Metabolic_Enzyme_8_Chromosome_Location:
Not Available

# Metabolic_Enzyme_8_Locus:
Not Available

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
1910331; 11434514

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5722

# Metabolic_Enzyme_9_Name:
UDP-glucuronosyltransferase 2B15 precursor

# Metabolic_Enzyme_9_Synonyms:
UDPGT; UDPGTh-3; HLUG4

# Metabolic_Enzyme_9_Gene_Name:
UGT2B15

# Metabolic_Enzyme_9_Protein_Sequence:
>UDPglucuronosyltransferase 2B15 precursor
MSLKWTSVFLLIQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVTVLTSSA
STLVNASKSSAIKLEVYPTSLTKNDLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEY
YDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGELLAELFNIPFLYSLRFSVGYT
FEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYSEV
LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
MSSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVA
AHNLTWIQYHSLDVIAFLLACVATVIFIITKFCLFCFRKLAKKGKKKKRD

# Metabolic_Enzyme_9_Number_of_Residues:
530

# Metabolic_Enzyme_9_Molecular_Weight:
60989

# Metabolic_Enzyme_9_Theoretical_pI:
9.04

# Metabolic_Enzyme_9_GO_Classification:
Not Available

# Metabolic_Enzyme_9_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens

# Metabolic_Enzyme_9_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_9_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_9_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_9_Signals:
1-23

# Metabolic_Enzyme_9_Transmembrane_Regions:
495-515

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_9_GenBank_ID_Protein:
23955933

# Metabolic_Enzyme_9_SwissProt_ID:
UDB15_HUMAN (P54855)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
UGT2B15

# Metabolic_Enzyme_9_Geneatlas_id:
UGT2B15

# Metabolic_Enzyme_9_hgnc_id:
HGNC:12546

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Microsome

# Metabolic_Enzyme_9_Gene_Sequence:
>1593 bp
ATGTCTCTGAAATGGACGTCAGTCTTTCTGCTGATACAGCTCAGTTGTTACTTTAGCTCT
GGAAGCTGTGGAAAGGTGCTAGTGTGGCCCACAGAATACAGCCATTGGATAAATATGAAG
ACAATCCTGGAAGAGCTTGTTCAGAGGGGTCATGAGGTGACTGTGTTGACATCTTCGGCT
TCTACTCTTGTCAATGCCAGTAAATCATCTGCTATTAAATTAGAAGTTTATCCTACATCT
TTAACTAAAAATGATTTGGAAGATTCTCTTCTGAAAATTCTCGATAGATGGATATATGGT
GTTTCAAAAAATACATTTTGGTCATATTTTTCACAATTACAAGAATTGTGTTGGGAATAT
TATGACTACAGTAACAAGCTCTGTAAAGATGCAGTTTTGAATAAGAAACTTATGATGAAA
CTACAAGAGTCAAAGTTTGATGTCATTCTGGCAGATGCCCTTAATCCCTGTGGTGAGCTA
CTGGCTGAACTATTTAACATACCCTTTCTGTACAGTCTTCGATTCTCTGTTGGCTACACA
TTTGAGAAGAATGGTGGAGGATTTCTGTTCCCTCCTTCCTATGTACCTGTTGTTATGTCA
GAATTAAGTGATCAAATGATTTTCATGGAGAGGATAAAAAATATGATACATATGCTTTAT
TTTGACTTTTGGTTTCAAATTTATGATCTGAAGAAGTGGGACCAGTTTTATAGTGAAGTT
CTAGGAAGACCCACTACATTATTTGAGACAATGGGGAAAGCTGAAATGTGGCTCATTCGA
ACCTATTGGGATTTTGAATTTCCTCGCCCATTCTTACCAAATGTTGATTTTGTTGGAGGA
CTTCACTGTAAACCAGCCAAACCCCTGCCTAAGGAAATGGAAGAGTTTGTGCAGAGCTCT
GGAGAAAATGGTATTGTGGTGTTTTCTCTGGGGTCGATGATCAGTAACATGTCAGAAGAA
AGTGCCAACATGATTGCATCAGCCCTTGCCCAGATCCCACAAAAGGTTCTATGGAGATTT
GATGGCAAGAAGCCAAATACTTTAGGTTCCAATACTCGACTGTACAAGTGGTTACCCCAG
AATGACCTTCTTGGTCATCCCAAAACCAAAGCTTTTATAACTCATGGTGGAACCAATGGC
ATCTATGAGGCGATCTACCATGGGATCCCTATGGTGGGCATTCCCTTGTTTGCGGATCAA
CATGATAACATTGCTCACATGAAAGCCAAGGGAGCAGCCCTCAGTGTGGACATCAGGACC
ATGTCAAGTAGAGATTTGCTCAATGCATTGAAGTCAGTCATTAATGACCCTGTCTATAAA
GAGAATGTCATGAAATTATCAAGAATTCATCATGACCAACCAATGAAGCCCCTGGATCGA
GCAGTCTTCTGGATTGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTTCGAGTCGCA
GCTCACAACCTCACCTGGATCCAGTACCACTCTTTGGATGTGATAGCATTCCTGCTGGCC
TGCGTGGCAACTGTGATATTTATCATCACAAAATTTTGCCTGTTTTGTTTCCGAAAGCTT
GCCAAAACAGGAAAGAAGAAGAAAAGAGATTAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AF548389

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_9_Locus:
4q13

# Metabolic_Enzyme_9_SNPs:
rs6825560; rs988562; rs1120265; rs1960773; rs7686914; rs988560; rs6839555; rs7682027; rs3100; rs9994887; rs1580083; rs7377952; rs7696472; rs6825748; rs13128530; rs1968719; rs1968718; rs7654523; rs1026337; rs1947435; rs1026338; rs2278917; rs1160212; rs12500760; rs4048844; rs7377954; rs12647504; rs4148271; rs2168050; rs2168051; rs6858676; rs35791822; rs13112099; rs7377950; rs34930215; rs17324486; rs5017546; rs2877378; rs1947434; rs5017549; rs17221777; rs35601514; rs6839657; rs11371462; rs5017544; rs2331421; rs2331422; rs6820752; rs4694747; rs12108552; rs34214136; rs4426857; rs35503231; rs5017548; rs35397066; rs5859136; rs2877377; rs10549990; rs2331423; rs5017545; rs34618890; rs5017547; rs5029385; rs1026339; rs5859137; rs34498614; rs34207963; rs3966095; rs1902023; rs4148269

# Metabolic_Enzyme_9_General_References:
7835232; 9295060; 2116769

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5734

# Metabolic_Enzyme_10_Name:
UDP-glucuronosyltransferase 2B11 precursor

# Metabolic_Enzyme_10_Synonyms:
UDPGT

# Metabolic_Enzyme_10_Gene_Name:
UGT2B11

# Metabolic_Enzyme_10_Protein_Sequence:
>UDPglucuronosyltransferase 2B11 precursor
MTLKWTSVLLLIHLSCYFSSGSCGKVLVWAAEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDASTLKFEVYPTSLTKTEFENIIMQQVKRWSDIRKDSFWLYFSQEQEILWELY
DIFRNFCKDVVSNKKVMKKLQESRFDIVFADAVFPCGELLAALLNIRFVYSLRFTPGYTI
ERHSGGLIFPPSYIPIVMSKLSDQMTFMERVKNMIYVLYFDFWFQMSDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNVDFVGGFHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRLDFNTM
SSTDLLNALKTVINDPLYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMPHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLACVATVIFIITKFCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_10_Number_of_Residues:
529

# Metabolic_Enzyme_10_Molecular_Weight:
61039

# Metabolic_Enzyme_10_Theoretical_pI:
9.29

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_10_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_10_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_10_Signals:
1-21

# Metabolic_Enzyme_10_Transmembrane_Regions:
493-513

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_10_GenBank_ID_Protein:
3360273

# Metabolic_Enzyme_10_SwissProt_ID:
UDB11_HUMAN (O75310)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
UGT2B11

# Metabolic_Enzyme_10_Geneatlas_id:
UGT2B11

# Metabolic_Enzyme_10_hgnc_id:
HGNC:12545

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Microsome

# Metabolic_Enzyme_10_Gene_Sequence:
>1590 bp
ATGACTCTGAAATGGACTTCAGTTCTTCTGCTGATACATCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAAGTGCTGGTGTGGGCCGCAGAATACAGCCATTGGATGAATATGAAG
ACAATCCTGAAAGAGCTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAATGATGCATCCACTCTTAAATTTGAAGTTTATCCTACATCT
TTAACTAAAACTGAATTTGAGAATATCATCATGCAACAGGTTAAGAGATGGTCAGACATT
CGAAAAGATAGCTTTTGGTTATATTTTTCACAAGAACAAGAAATCCTGTGGGAATTATAT
GACATATTTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAAGTTATGAAAAAACTA
CAAGAGTCAAGATTTGACATCGTTTTTGCAGATGCTGTTTTTCCCTGTGGTGAGCTGCTG
GCTGCGCTACTTAACATACGGTTTGTGTACAGTCTCCGCTTTACTCCTGGCTACACAATT
GAAAGGCACAGTGGAGGACTGATTTTCCCTCCTTCCTACATACCTATTGTTATGTCAAAA
TTAAGTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTATTTT
GACTTTTGGTTCCAAATGTCTGATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTA
GGAAGACCCACTACCTTATTTGAGACAATGGGAAAAGCTGACATATGGCTTATGCGAAAC
TCCTGGAGTTTTCAATTTCCTCATCCATTCTTACCAAACGTTGATTTTGTTGGAGGATTC
CACTGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAGTTTGTACAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAGTGATAAGTAACATGACAGCAGAAAGG
GCCAATGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAC
GGGAATAAACCAGATGCCTTAGGTCTCAATACTCGGCTGTACAAGTGGATACCCCAGAAT
GACCTTCTAGGTCATCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATGAGGCAATCTACCATGGGATCCCTATGGTGGGCATTCCATTGTTTTTTGATCAACCT
GATAACATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGATTGGACTTCAACACAATG
TCGAGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTTATATAAAGAG
AATATTATGAAATTATCAAGAATTCAACATGATCAACCAGTAAAGCCCCTGGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCCCCACAAAGGAGCCAAACACCTTCGAGTTGCAGCC
CATGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTTCTGCTGGCCTGT
GTGGCAACTGTGATATTTATCATCACAAAGTTTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGGGAAGAAGGGAAAAAGAGATTAG

# Metabolic_Enzyme_10_GenBank_ID_Gene:
AF016492

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_10_Locus:
4q13.2

# Metabolic_Enzyme_10_SNPs:
rs4694697; rs4415023; rs4400059; rs4543201; rs4283741; rs11945946; rs7436729; rs11947293; rs4463131; rs6833028; rs12500268; rs4608875; rs7688262; rs7697037; rs3890590; rs7697482; rs35248576; rs11340393; rs5859168; rs4485863; rs28743034; rs4619960; rs13148581; rs13113479; rs4406085; rs34519957; rs13119196; rs28561592; rs4406086; rs13134572; rs7660257; rs13148525; rs35902951; rs13148376; rs4386666; rs13134364; rs13113695; rs4485864; rs13107183; rs7660248; rs13119170; rs13103028; rs13134363; rs35555504; rs13139597; rs35443238; rs28470680; rs13113271; rs13119197; rs13107219; rs10007587; rs4466107; rs10434518; rs34416320; rs10007579; rs6847476; rs10012181; rs9996390; rs12502502; rs13123057; rs4526045; rs4694199; rs6817250; rs6825376; rs7672567; rs7682460; rs7695331

# Metabolic_Enzyme_10_General_References:
9675083

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5728

# Metabolic_Enzyme_11_Name:
UDP-glucuronosyltransferase 1-3 precursor

# Metabolic_Enzyme_11_Synonyms:
UDP- glucuronosyltransferase 1A3; UDPGT; UGT1*3; UGT1-03; UGT1.3; UGT- 1C; UGT1C

# Metabolic_Enzyme_11_Gene_Name:
UGT1A3

# Metabolic_Enzyme_11_Protein_Sequence:
>UDPglucuronosyltransferase 13 precursor
MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVV
LTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNM
SLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDL
DFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQ
REVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_11_Number_of_Residues:
534

# Metabolic_Enzyme_11_Molecular_Weight:
60339

# Metabolic_Enzyme_11_Theoretical_pI:
8.28

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_11_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_11_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_11_Signals:
1-28

# Metabolic_Enzyme_11_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_11_GenBank_ID_Protein:
340135

# Metabolic_Enzyme_11_SwissProt_ID:
UD13_HUMAN (P35503)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
UGT1A3

# Metabolic_Enzyme_11_Geneatlas_id:
UGT1A3

# Metabolic_Enzyme_11_hgnc_id:
HGNC:12535

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Microsome

# Metabolic_Enzyme_11_Gene_Sequence:
>867 bp
ATGGCCACAGGACTCCAGGTTCCCCTGCCGTGGCTGGCCACAGGACTGCTGCTTCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCATTGATGGCAGCCAC
TGGCTCAGCATGCGGGAGGTCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCAGTGGTC
CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAACTTTTTCACCCTGACAACCTAT
GCCATTTCGTGGACCCAGGATGAATTTGATCGCCATGTGCTGGGCCACACTCAACTGTAC
TTTGAAACAGAACATTTTCTGAAGAAATTTTTCAGAAGTATGGCAATGTTGAACAATATG
TCTTTGGTCTATCATAGGTCTTGTGTGGAGCTACTACATAATGAGGCCCTGATCAGGCAC
CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGCGCGGCAGTG
CTGGCTAAGTACCTGTCGATTCCTACTGTGTTTTTTTTGAGGAACATTCCATGTGATTTA
GACTTTAAGGGCACACAGTGTCCAAACCCTTCCTCCTATATTCCTAGATTACTAACAACC
AATTCAGACCACATGACATTCATGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACATTTGCCATGCTTTTTCTGCTCCTTATGCAAGCCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATATTCTCAGTCATGCATCTGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGACTACCCCAGGCCAATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACAGGAAGCCACTATCTCAG

# Metabolic_Enzyme_11_GenBank_ID_Gene:
M84127

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_11_Locus:
2q37

# Metabolic_Enzyme_11_SNPs:
Not Available

# Metabolic_Enzyme_11_General_References:
1339448; 11434514

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5732

# Metabolic_Enzyme_12_Name:
UDP-glucuronosyltransferase 1-6 precursor

# Metabolic_Enzyme_12_Synonyms:
UDP- glucuronosyltransferase 1A6; UDPGT; UGT1*6; UGT1-06; UGT1.6; UGT- 1F; UGT1F; Phenol-metabolizing UDP-glucuronosyltransferase

# Metabolic_Enzyme_12_Gene_Name:
UGT1A6

# Metabolic_Enzyme_12_Protein_Sequence:
>UDPglucuronosyltransferase 16 precursor
MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVV
PEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIG
LYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEH
TFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRD
VDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHG
IVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLL
GHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSE
DLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDL
TWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_12_Number_of_Residues:
532

# Metabolic_Enzyme_12_Molecular_Weight:
60751

# Metabolic_Enzyme_12_Theoretical_pI:
8.55

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_12_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols

# Metabolic_Enzyme_12_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_12_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_12_Signals:
1-26

# Metabolic_Enzyme_12_Transmembrane_Regions:
490-506

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_12_GenBank_ID_Protein:
340141

# Metabolic_Enzyme_12_SwissProt_ID:
UD16_HUMAN (P19224)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
UGT1A6

# Metabolic_Enzyme_12_Geneatlas_id:
UGT1A6

# Metabolic_Enzyme_12_hgnc_id:
HGNC:12538

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Microsome

# Metabolic_Enzyme_12_Gene_Sequence:
>861 bp
ATGGCCTGCCTCCTTCGCTCATTTCAGAGAATTTCTGCAGGGGTTTTCTTCTTAGCACTT
TGGGGCATGGTTGTAGGTGACAAGCTGCTGGTGGTCCCTCAGGACGGAAGCCACTGGCTT
AGTATGAAGGATATAGTTGAGGTTCTCAGTGACCGGGGTCATGAGATTGTAGTGGTGGTG
CCTGAAGTTAATTTGCTTTTGAAAGAATCCAAATACTACACAAGAAAAATCTATCCAGTG
CCGTATGACCAAGAAGAGCTGAAGAACCGTTACCAATCATTTGGAAACAATCACTTTGCT
GAGCGATCATTCCTAACTGCTCCTCAGACAGAGTACAGGAATAACATGATTGTTATTGGC
CTGTACTTCATCAACTGCCAGAGCCTCCTGCAGGACAGGGACACCCTGAACTTCTTTAAG
GAGAGCAAGTTTGATGCTCTTTTCACAGACCCAGCCTTACCCTGTGGGGTGATCCTGGCT
GAGTATTTGGGCCTACCATCTGTGTACCTCTTCAGGGGTTTTCCGTGTTCCCTGGAGCAT
ACATTCAGCAGAAGCCCAGACCCTGTGTCCTACATTCCCAGGTGCTACACAAAGTTTTCA
GACCACATGACTTTTTCCCAACGAGTGGCCAACTTCCTTGTTAATTTGTTGGAGCCCTAT
CTATTTTATTGTCTGTTTTCAAAGTATGAAGAACTCGCATCAGCTGTCCTCAAGAGAGAT
GTGGATATAATCACCTTATATCAGAAGGTCTCTGTTTGGCTGTTAAGATATGACTTTGTG
CTTGAATATCCTAGGCCGGTCATGCCCAACATGGTCTTCATTGGAGGTATCAACTGTAAG
AAGAGGAAAGACTTGTCTCAG

# Metabolic_Enzyme_12_GenBank_ID_Gene:
M84130

# Metabolic_Enzyme_12_Chromosome_Location:
Not Available

# Metabolic_Enzyme_12_Locus:
Not Available

# Metabolic_Enzyme_12_SNPs:
Not Available

# Metabolic_Enzyme_12_General_References:
1339448; 3141926; 11434514; 9466822; 9429234

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5733

# Metabolic_Enzyme_13_Name:
UDP-glucuronosyltransferase 1-5 precursor

# Metabolic_Enzyme_13_Synonyms:
UDP- glucuronosyltransferase 1A5; UDPGT; UGT1*5; UGT1-05; UGT1.5; UGT- 1E; UGT1E

# Metabolic_Enzyme_13_Gene_Name:
UGT1A5

# Metabolic_Enzyme_13_Protein_Sequence:
>UDPglucuronosyltransferase 15 precursor
MATGLQVPLPQLATGLLLLLSVQPWAESGKVLVVPTDGSHWLSMREALRDLHARGHQVVV
LTLEVNMYIKEENFFTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNM
SLIIHRSCVELLHNEALIRHLHATSFDVVLTDPFHLCAAVLAKYLSIPAVFFLRNIPCDL
DFKGTQCPNPSSYIPRLLTTNSDHMTFLQRVKNMLYPLALSYLCHAVSAPYASLASELFQ
REVSVVDLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_13_Number_of_Residues:
534

# Metabolic_Enzyme_13_Molecular_Weight:
60072

# Metabolic_Enzyme_13_Theoretical_pI:
8.14

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_13_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_13_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_13_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_13_Signals:
1-28

# Metabolic_Enzyme_13_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_13_GenBank_ID_Protein:
340139

# Metabolic_Enzyme_13_SwissProt_ID:
UD15_HUMAN (P35504)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
UGT1A5

# Metabolic_Enzyme_13_Geneatlas_id:
UGT1A5

# Metabolic_Enzyme_13_hgnc_id:
HGNC:12537

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Microsome

# Metabolic_Enzyme_13_Gene_Sequence:
>867 bp
ATGGCCACAGGACTCCAGGTTCCCCTGCCGCAGCTGGCCACAGGACTGCTGCTTCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGGAAGGTGCTGGTGGTGCCCACTGATGGCAGCCAC
TGGCTCAGCATGCGGGAGGCCTTGCGGGACCTCCATGCGAGAGGCCACCAGGTGGTGGTC
CTCACCCTGGAGGTGAATATGTACATCAAAGAAGAGAACTTTTTCACCCTGACAACGTAT
GCCATTTCATGGACCCAGGACGAATTTGATCGCCTTTTGCTGGGTCACACTCAATCGTTC
TTTGAAACAGAACATCTTCTGATGAAATTTTCTAGAAGAATGGCAATTATGAACAATATG
TCTTTGATCATACATAGGTCTTGTGTGGAGCTACTGCATAATGAGGCCCTGATCAGGCAC
CTGCATGCTACTTCCTTTGATGTGGTTCTAACAGACCCCTTTCACCTCTGCGCGGCGGTG
CTGGCTAAGTACCTGTCGATTCCTGCTGTGTTTTTCTTGAGGAACATTCCATGTGATTTA
GACTTTAAGGGCACACAGTGTCCAAACCCTTCCTCCTATATTCCTAGATTACTAACGACC
AATTCAGACCACATGACATTCCTGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACCTTTGCCATGCTGTTTCTGCTCCTTATGCAAGCCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATCTTGTCAGCCATGCATCTGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGATTACCCCAGGCCGATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACGGGAAGCCACTATCTCAG

# Metabolic_Enzyme_13_GenBank_ID_Gene:
M84129

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_13_Locus:
2q37

# Metabolic_Enzyme_13_SNPs:
Not Available

# Metabolic_Enzyme_13_General_References:
1339448; 11434514

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5973

# Metabolic_Enzyme_14_Name:
Biliverdin reductase A precursor

# Metabolic_Enzyme_14_Synonyms:
Biliverdin-IX alpha- reductase; BVR A

# Metabolic_Enzyme_14_Gene_Name:
BLVRA

# Metabolic_Enzyme_14_Protein_Sequence:
>Biliverdin reductase A precursor
MNAEPERKFGVVVVGVGRAGSVRMRDLRNPHPSSAFLNLIGFVSRRELGSIDGVQQISLE
DALSSQEVEVAYICSESSSHEDYIRQFLNAGKHVLVEYPMTLSLAAAQELWELAEQKGKV
LHEEHVELLMEEFAFLKKEVVGKDLLKGSLLFTAGPLEEERFGFPAFSGISRLTWLVSLF
GELSLVSATLEERKEDQYMKMTVCLETEKKSPLSWIEEKGPGLKRNRYLSFHFKSGSLEN
VPNVGVNKNIFLKDQNIFVQKLLGQFSEKELAAEKKRILHCLGLAEEIQKYCCSRK

# Metabolic_Enzyme_14_Number_of_Residues:
296

# Metabolic_Enzyme_14_Molecular_Weight:
33429

# Metabolic_Enzyme_14_Theoretical_pI:
6.41

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Not Available

# Metabolic_Enzyme_14_Specific_Function:
Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor

# Metabolic_Enzyme_14_Pathway:
map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_14_Reaction:
bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF09166:Biliv-reduc_cat;
PF01408:GFO_IDH_MocA

# Metabolic_Enzyme_14_Signals:
None

# Metabolic_Enzyme_14_Transmembrane_Regions:
None

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 1.3.1.24

# Metabolic_Enzyme_14_GenBank_ID_Protein:
1246749

# Metabolic_Enzyme_14_SwissProt_ID:
BIEA_HUMAN (P53004)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
BLVRA

# Metabolic_Enzyme_14_Geneatlas_id:
BLVRA

# Metabolic_Enzyme_14_hgnc_id:
HGNC:1062

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_14_Gene_Sequence:
>891 bp
ATGAATGCAGAGCCCGAGAGGAAGTTTGGCGTGGTGGTGGTTGGTGTTGGCCGAGCCGGC
TCCGTGCGGATGAGGGACTTGCGGAATCCACACCCTTCCTCAGCGTTCCTGAACCTGATT
GGCTTCGTGTCGAGAAGGGAGCTCGGGAGCATTGATGGAGTCCAGCAGATTTCTTTGGAG
GATGCTCTTTCCAGCCAAGAGGTGGAGGTCGCCTATATCTGCAGTGAGAGCTCCAGCCAT
GAGGACTACATCAGGCAGTTCCTTAATGCTGGCAAGCACGTCCTTGTGGAATACCCCATG
ACACTGTCATTGGCGGCCGCTCAGGAACTGTGGGAGCTGGCTGAGCAGAAAGGAAAAGTC
TTGCACGAGGAGCATGTTGAACTCTTGATGGAGGAATTCGCTTTCCTGAAAAAAGAAGTG
GTGGGGAAAGACCTGCTGAAAGGGTCGCTCCTCTTCACATCTGACCCGTTGGAAGAAGAC
CGGTTTGGCTTCCCTGCATTCAGCGGCATCTCTCGACTGACCTGGCTGGTCTCCCTCTTT
GGGGAGCTTTCTCTTGTGTCTGCCACTTTGGAAGAGCGAAAGGAAGATCAGTATATGAAA
ATGACAGTGTGTCTGGAGACAGAGAAGAAAAGTCCACTGTCATGGATTGAAGAAAAAGGA
CCTGGTCTAAAACGAAACAGATATTTAAGCTTCCATTTCAAGTCTGGGTCCTTGGAGAAT
GTGCCAAATGTAGGAGTGAATAAGAACATATTTCTGAAAGATCAAAATATATTTGTCCAG
AAACTCTTGGGCCAGTTCTCTGAGAAGGAACTGGCTGCTGAAAAGAAACGCATCCTGCAC
TGCCTGGGGCTTGCAGAAGAAATCCAGAAATATTGCTGTTCAAGGAAGTAA

# Metabolic_Enzyme_14_GenBank_ID_Gene:
X93086

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_14_Locus:
7p14-cen

# Metabolic_Enzyme_14_SNPs:
rs699512; rs1050916; rs17245918; rs7738; rs9632617; rs1131372; rs849184; rs699510; rs1181574; rs10245471; rs4724242; rs10225380; rs699511; rs1181573; rs1637532; rs10486752; rs2302032; rs10233867; rs7803741; rs7783986; rs7784427; rs7804430; rs7784710; rs7804638; rs10225808; rs7803722; rs17239460; rs2330921; rs7788416; rs7793236; rs17245841; rs7784666; rs10260060; rs7784876; rs7805033; rs7784790; rs7785115; rs10233888; rs6972339; rs10229363; rs2246171; rs2877262; rs849165; rs2282922; rs10229520; rs2730625; rs849163; rs2330952; rs1306742; rs3094951; rs849162; rs1317916; rs849161; rs1181576; rs2074795; rs3107888; rs17246016; rs11982143; rs10244587; rs17245981; rs849185; rs2690381; rs10268054; rs1181572; rs10234057; rs3107889; rs2299149; rs17239727; rs11306210; rs17239601; rs10695215; rs10280853; rs17246086; rs17239608; rs17239537; rs17245946; rs1181577; rs6978907; rs17245869; rs17246002; rs17245932; rs17246100; rs7785330; rs17246121; rs17239558; rs17239678; rs17239565; rs17239685; rs10254271; rs17239657; rs17239523; rs17239664; rs17246135; rs10250951; rs17239509; rs17239713; rs2158952; rs11973765; rs17239572; rs17239671; rs17239544; rs17239692; rs12673217; rs3094952; rs17246065; rs10240388; rs1799077; rs17245785; rs1637530; rs17239409; rs17856154; rs17245911; rs17850330; rs1802849; rs34027937; rs17245834; rs34953729; rs17239423; rs11419474; rs34085711; rs7805389; rs2690385; rs13222245; rs7805153; rs2730631; rs10583379; rs28707680; rs17239432; rs17245799; rs13222143; rs2730630; rs36008307; rs11760630; rs34298554; rs6966862; rs34787806; rs17239439; rs13241746; rs13222507; rs6951295; rs17245827; rs34256119; rs34361520; rs849183; rs34892644; rs2690384; rs34000003; rs4580947; rs36184743; rs36137441; rs17245897; rs17239495; rs2730606; rs17239622; rs28793411; rs35792323; rs3965475; rs35238622; rs17245876; rs17245883; rs17246023; rs36198504; rs17246072; rs35572942; rs36155448; rs36065452; rs17246044; rs34278744; rs17245925; rs17239481; rs17246009; rs17239720; rs17239530; rs34850514; rs5883874; rs13223183; rs36200736; rs12386638; rs28662150; rs10255811; rs28697916; rs36156479; rs17246114; rs1181575; rs17245890; rs13307958; rs34234974; rs17245988; rs35149435; rs17246030; rs5883875; rs28856095; rs1306743; rs35816005; rs34519492; rs36121270; rs34828844; rs35798806; rs17245939; rs17239516; rs1859871; rs17239628; rs36184468; rs17239615; rs34011643; rs17239593; rs10701241; rs28458462; rs17239488; rs34583169; rs34404101; rs36198252; rs17245967; rs36191968; rs35592453; rs1859872; rs6953918; rs17245974; rs36199636; rs11983551; rs10272931; rs849164; rs36200068; rs17245855; rs17245862; rs3063069; rs13241202; rs2529585; rs17239741; rs35579130; rs9692130; rs17245764; rs17239416; rs1637531; rs10650484; rs17239382; rs10665152; rs11767476; rs33964150; rs17239396; rs17239402; rs35368902; rs17245778; rs10227643; rs1181597; rs1181598; rs1181599; rs1181600; rs1181601; rs1181602; rs1181603; rs12672084; rs2529584; rs589570; rs645853; rs730584; rs734353

# Metabolic_Enzyme_14_General_References:
8631357; 12853948; 8424666; 7929092

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5696

# Metabolic_Enzyme_15_Name:
UDP-glucuronosyltransferase 2B4 precursor

# Metabolic_Enzyme_15_Synonyms:
UDPGT; Hyodeoxycholic acid; HLUG25; UDPGTh-1

# Metabolic_Enzyme_15_Gene_Name:
UGT2B4

# Metabolic_Enzyme_15_Protein_Sequence:
>UDPglucuronosyltransferase 2B4 precursor
MSMKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLASSA
SISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFN
DILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFGELLAELLKIPFVYSLRFSPGYAI
EKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVL
GRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSMVSNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTM
SSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVTGFLLACVATVIFIITKCLFCVWKFVRTGKKGKRD

# Metabolic_Enzyme_15_Number_of_Residues:
528

# Metabolic_Enzyme_15_Molecular_Weight:
60513

# Metabolic_Enzyme_15_Theoretical_pI:
8.75

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_15_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid

# Metabolic_Enzyme_15_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_15_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_15_Signals:
1-23

# Metabolic_Enzyme_15_Transmembrane_Regions:
493-509

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_15_GenBank_ID_Protein:
37589

# Metabolic_Enzyme_15_SwissProt_ID:
UDB4_HUMAN (P06133)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
UGT2B4

# Metabolic_Enzyme_15_Geneatlas_id:
UGT2B4

# Metabolic_Enzyme_15_hgnc_id:
HGNC:12553

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Microsome

# Metabolic_Enzyme_15_Gene_Sequence:
>1587 bp
ATGTCTATGAAATGGACTTCAGCTCTTCTGCTGATACAGCTGAGCTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATTCAGCCACTGGATGAATATAAAG
ACAATCCTGGATGAACTTGTCCAGAGAGGTCATGAGGTGACTGTATTGGCATCTTCAGCT
TCCATTTCTTTCGATCCCAACAGCCCATCTACTCTTAAATTTGAAGTTTATCCTGTATCT
TTAACTAAAACTGAGTTTGAGGATATTATCAAGCAGCTGGTTAAGAGATGGGCAGAACTT
CCAAAAGACACATTTTGGTCATATTTTTCACAAGTACAAGAAATCATGTGGACATTTAAT
GACATACTTAGAAAGTTCTGTAAGGATATAGTTTCAAATAAGAAACTTATGAAGAAACTA
CAGGAGTCAAGATTTGATGTTGTTCTTGCAGATGCTGTTTTCCCCTTTGGTGAGCTGCTG
GCCGAGTTACTTAAAATACCCTTTGTCTACAGGCCTCGCTTCTCTCCTGGCTACGCAATT
GAAAAGCATAGTGGAGGACTTCTGTTCCCTCCTTCCTATGTGCCTGTTGTTATGTCAGAA
CTAAGTGACCAAATGACTTTCATAGAGAGGGTAAAAAATATGATCTATGTGCTTTATTTT
GAATTTTGGTTCCAAATATTTGACATGAAGAAGTGGGATCAGTTCTACAGTGAAGTTCTA
GGAAGACCCACTACGTTATCTGAGACAATGGCAAAAGCTGACATATGGCTTATTCGAAAC
TACTGGGATTTTCAATTTCCTCACCCACTCTTACCAAATGTTGAGTTCGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTACCGAAGGAAATGGAAGAGTTTGTCCAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCGATGGTCAGTAACACGTCAGAAGAAAGG
GCCAATGTAATTGCATCAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATACTTTAGGACTCAATACTCGGCTGTACAAGTGGATACCCCAGAAT
GATCTTCTTGGTCACCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATAAGGCAATCTCTCCTAGAATCCCTATGGTGGGCGTTCCATTGTTTGCAGATCAACCT
GATAACATTGCACACATGAAGGCCAAGGGAGCAGCTGTTAGTTTGGACTTCCACACAATG
TCGAGTACAGACTTACTCAATGCACTGAAGACAGTAATTAATGATCCTTTATATAAAGAG
AATGCTATGAAATTATCAAGAATTCATCATGATCAACCAGTGAAGCCCCTTGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTTGCAGCC
CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGACTGGGTTCCTGCTGGCCTGT
GTGGCAACTGTGATATTCATCATCACAAAATGTCTGTTTTGTGTCTGGAAGTTTGTTAGA
ACAGGAAAGAAGGGGAAAAGAGATTAA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
Y00317

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_15_Locus:
4q13

# Metabolic_Enzyme_15_SNPs:
rs13119049; rs41297431; rs13142440; rs1131878; rs1966151; rs1051752; rs7662902; rs1389930; rs1826690; rs7441743; rs1039007; rs2220857; rs2013562; rs1845557; rs6833511; rs13116232; rs12645716; rs9997034; rs1994936; rs1039008; rs4554145; rs28542932; rs10030234; rs10518061; rs17614939; rs13104260; rs10010875; rs3822179; rs33914959; rs1845556; rs6848208; rs17671289; rs1977017; rs28361541; rs41297733; rs41297437; rs1997581; rs41297373; rs41299996; rs41297395; rs41297371; rs41300016; rs41297381; rs41297421; rs1908406; rs41297427; rs41297377; rs41297425; rs41297367; rs4557343; rs1845558; rs3075630; rs41297405; rs41297739; rs41297383; rs41297721; rs13151870; rs41297441; rs13145834; rs13104687; rs11249442; rs41297407; rs41297429; rs41297727; rs1121124; rs2013573; rs41299994; rs13139888; rs41297439; rs41297409; rs1494802; rs13111134; rs6600771; rs6820660; rs6821129; rs941389; rs2736446; rs1080755; rs2736442; rs28858389; rs2736441; rs41298271; rs41298263; rs41299972; rs41298261; rs41298251; rs13129471; rs41299970; rs6821910; rs41298253; rs41298259; rs41298265; rs41298245; rs41299978; rs41299976; rs41299974; rs41300004; rs17852375; rs1845555; rs41298247; rs28679647; rs324405; rs41300006; rs36048401; rs1432328; rs41297387; rs41299984; rs41299998; rs41299992; rs41297735; rs41297423; rs35143721; rs1370886; rs41299980; rs41297389; rs41297729; rs7441132; rs41297435; rs34002802; rs41297731; rs41300018; rs35138624; rs41297391; rs41297369; rs41297737; rs41297413; rs13141359; rs41292303; rs41300008; rs2736447; rs41300014; rs41297401; rs34874998; rs1370887; rs41297399; rs41297379; rs172861; rs41297375; rs10613760; rs41297433; rs41297723; rs41297403; rs41297741; rs1821190; rs34030380; rs324406; rs41299986; rs41297393; rs41297385; rs41297419; rs41297365; rs35471760; rs34861432; rs4515233; rs324408; rs41297411; rs2018304; rs41300012; rs13114834; rs41297415; rs28629208; rs41300002; rs41300000; rs41300010; rs41297743; rs41297397; rs41299990; rs28419590; rs983988; rs34164957; rs1370885; rs324407; rs34466016; rs41297725; rs41297417; rs34114694; rs41299988; rs41299982; rs41299966; rs34846583; rs35045255; rs35834953; rs34169605; rs1318156; rs2642856; rs35159034; rs41298257; rs41298249; rs2736445; rs3075626; rs41299968; rs28847667; rs34146174; rs36057237; rs28812576; rs941390; rs41298255; rs28894673; rs41298269; rs1080756; rs41298267; rs10000231; rs10015297; rs11725944; rs11725945; rs13141436; rs13143630; rs1569343; rs1569344; rs1594588; rs1603119; rs1948499; rs2010468; rs2642849; rs2642872; rs2736462; rs2736476; rs2736517; rs2736520; rs35347166; rs4694749; rs7657880; rs903445; rs903446; rs9996511

# Metabolic_Enzyme_15_General_References:
3109396; 8333863; 10376768

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5730

# Metabolic_Enzyme_16_Name:
UDP-glucuronosyltransferase 1-10 precursor

# Metabolic_Enzyme_16_Synonyms:
UDPGT; UGT1*10; UGT1-10; UGT1.10; UGT-1J; UGT1J

# Metabolic_Enzyme_16_Gene_Name:
UGT1A10

# Metabolic_Enzyme_16_Protein_Sequence:
>UDPglucuronosyltransferase 110 precursor
MARAGWTSPVPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLF
FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEG
AQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_16_Number_of_Residues:
530

# Metabolic_Enzyme_16_Molecular_Weight:
59810

# Metabolic_Enzyme_16_Theoretical_pI:
7.31

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_16_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_16_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_16_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_16_Signals:
1-25

# Metabolic_Enzyme_16_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_16_GenBank_ID_Protein:
2039362

# Metabolic_Enzyme_16_SwissProt_ID:
UD110_HUMAN (Q9HAW8)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
UGT1A10

# Metabolic_Enzyme_16_Geneatlas_id:
UGT1A10

# Metabolic_Enzyme_16_hgnc_id:
HGNC:12531

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Microsome

# Metabolic_Enzyme_16_Gene_Sequence:
>1593 bp
ATGGCTCCGCGCAGGGTGGACCAGCCCCGTTCCTTTATGTGTGTGTCTACTGCTGACCTG
TGGCTTTGCGAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGTCACTGGTTCGCC
ATGCAGTCGGTGGTGGAGAAACTTATCCTCAGGGGGCATGAGGTGGTTGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGAAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCG
TACACTCTGGAAGATCAGAACCGGGAATTCATGGTTTTCGCCCATGCTCAATGGAAAGCA
CAGGCACAAAGTATATTTTCTCTATTAATGAGTTCATCCAGTGGTTTTCTTGACTTATTT
TTTTCGCATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCAGTGTTTCTGGATCCTTTTGATACCTGTGGCTTAATTGTTGCTAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCACCAGGGGAATATTTTGCCGCCATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAATGATCTCTTAGGGTTCTCAGATGCC
ATGACTTTCAAGGAGAGAGTATGGAACCACATCGTGCACTTGGAGGACCATTTATTTTGC
CAGTATCTTTTAAGAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGTCACACATCAATTTGGTTGTTGCGAACGGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAACATGATCTTCATTGGTGGTATCAACTGTCATCAGGGA
AAGCCATTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
U89508

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_16_Locus:
2q37

# Metabolic_Enzyme_16_SNPs:
Not Available

# Metabolic_Enzyme_16_General_References:
9271343; 11434514

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5721

# Metabolic_Enzyme_17_Name:
UDP-glucuronosyltransferase 2B7 precursor

# Metabolic_Enzyme_17_Synonyms:
UDPGT; 3,4- catechol estrogen specific; UDPGTh-2

# Metabolic_Enzyme_17_Gene_Name:
UGT2B7

# Metabolic_Enzyme_17_Protein_Sequence:
>UDPglucuronosyltransferase 2B7 precursor
MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSA
SILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFG
DITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTF
EKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVL
GRPTTLSETMGKADVWLIRNSWNFQFPHPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSG
ENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTM
SSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND

# Metabolic_Enzyme_17_Number_of_Residues:
529

# Metabolic_Enzyme_17_Molecular_Weight:
60695

# Metabolic_Enzyme_17_Theoretical_pI:
8.45

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_17_Specific_Function:
Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites

# Metabolic_Enzyme_17_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_17_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_17_Signals:
1-23

# Metabolic_Enzyme_17_Transmembrane_Regions:
493-509

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_17_GenBank_ID_Protein:
340080

# Metabolic_Enzyme_17_SwissProt_ID:
UDB7_HUMAN (P16662)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
UGT2B7

# Metabolic_Enzyme_17_Geneatlas_id:
UGT2B7

# Metabolic_Enzyme_17_hgnc_id:
HGNC:12554

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Microsome

# Metabolic_Enzyme_17_Gene_Sequence:
>1590 bp
ATGTCTGTGAAATGGACTTCAGTAATTTTGCTAATACAACTGAGCTTTTGCTTTAGCTCT
GGGAATTGTGGAAAGGTGCTGGTGTGGGCAGCAGAATACAGCCATTGGATGAATATAAAG
ACAATCCTGGATGAGCTTATTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAACAACTCATCCGCTCTTAAAATTGAAATTTATCCCACATCT
TTAACTAAAACTGAGTTGGAGAATTTCATCATGCAACAGATTAAGAGATGGTCAGACCTT
CCAAAAGATACATTTTGGTTATATTTTTCACAAGTACAGGAAATCATGTCAATATTTGGT
GACATAACTAGAAAGTTCTGTAAAGATGTAGTTTCAAATAAGAAATTTATGAAAAAAGTA
CAAGAGTCAAGATTTGACGTCATTTTTGCAGATGCTATTTTTCCCTGTAGTGAGCTGCTG
GCTGAGCTATTTAACATACCCTTTGTGTACAGTCTCAGCTTCTCTCCTGGCTACACTTTT
GAAAAGCATAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAGAA
TTAACTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTACTTT
GACTTTTGGTTCGAAATATTTGACATGAAGAAGTGGGATCAGTTTTATAGTGAAGTTCTA
GGAAGACCCACTACGTTATCTGAGACAATGGGGAAAGCTGACGTATGGCTTATTCGAAAC
TCCTGGAATTTTCAGTTTCCTCATCCACTCTTACCAAATGTTGATTTTGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTGCCTAAGGAAATGGAAGACTTTGTACAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGG
GCCAACGTAATTGCATCAGCCCTGGCCCAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATACCTTAGGTCTCAATACTCGGCTGTATAAGTGGATACCCCAGAAT
GACCTTCTAGGTCATCCAAAGACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TACGAGGCAATCTACCATGGGATCCCTATGGTGGGGATTCCATTGTTTGCCGATCAACCT
GATAACATTGCTCACATGAAGGCCAGGGGAGCAGCTGTTAGAGTGGACTTCAACACAATG
TCGAGTACAGACTTGCTGAATGCATTGAAGAGAGTAATTAATGATCCTTCATATAAAGAG
AATGTTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCTAAACACCTTCGGGTTGCAGCC
CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGTCTGT
GTGGCAACTGTGATATTTATCGTCACAAAATGTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGCAAAGAAGGGAAAAAATGATTAG

# Metabolic_Enzyme_17_GenBank_ID_Gene:
J05428

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_17_Locus:
4q13

# Metabolic_Enzyme_17_SNPs:
rs7439366; rs12233719; rs35590824; rs7438284; rs4348159; rs4292394; rs28365062; rs5013211; rs7686056; rs6600884; rs7441750; rs7439152; rs12513195; rs4293848; rs3924192; rs7442453; rs7698846; rs7678656; rs12506962; rs7441774; rs6600888; rs6858558; rs6600885; rs6600891; rs7375178; rs7435335; rs6600890; rs6600887; rs7438244; rs4521414; rs6600889; rs12647682; rs7434332; rs12508257; rs4694628; rs6600886; rs4314347; rs12647681; rs7439326; rs7698645; rs12512526; rs10028494; rs9995928; rs3924194; rs6600892; rs4364327; rs3924193; rs12642938; rs4337789; rs7679184; rs12648462; rs10050146; rs4257713; rs4588522; rs4356975; rs7693957; rs7658752; rs4314345; rs7438942; rs4351080; rs4541594; rs10006452; rs6851533; rs6600880; rs7438135; rs11940316; rs6600879; rs7668282; rs7668258; rs4538548; rs6600883; rs6600893; rs7662029; rs4455491; rs11940220; rs4554144; rs5859163; rs34620993; rs34851008; rs34308305; rs34661811; rs35327868; rs35893826; rs10022440; rs13136922; rs34407256; rs35452834; rs34095769; rs5859161; rs34241812; rs34302283; rs34386959; rs35475910; rs34561399; rs28675300; rs34556519; rs28673873; rs35185848; rs28539948; rs34571475; rs34318523; rs35402056; rs5859162; rs34182209; rs4694177; rs28375964; rs35605246; rs11302069; rs10008743; rs5859160; rs4356974; rs34630750; rs7437605; rs6819882; rs34590280; rs11249527; rs11249528; rs12506592; rs13118991; rs13135225; rs28365063; rs4274916; rs4358465; rs4434330; rs4535394; rs4694169; rs6422323; rs6422324; rs6600876; rs6843382; rs7437174; rs7657423; rs7676472

# Metabolic_Enzyme_17_General_References:
2159463; 11186130

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5687

# Metabolic_Enzyme_18_Name:
UDP-glucuronosyltransferase 2B28 precursor

# Metabolic_Enzyme_18_Synonyms:
UDPGT

# Metabolic_Enzyme_18_Gene_Name:
UGT2B28

# Metabolic_Enzyme_18_Protein_Sequence:
>UDPglucuronosyltransferase 2B28 precursor
MALKWTSVLLLIHLGCYFSSGSCGKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDIQKDSFWLYFSQEQEILWEFH
DIFRNFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTI
ERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWFQMCDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTM
SSTDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAA
RDLTWFQYHSLDVIGFLLACVATVIFVVTKFCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_18_Number_of_Residues:
529

# Metabolic_Enzyme_18_Molecular_Weight:
60907

# Metabolic_Enzyme_18_Theoretical_pI:
8.80

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_18_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta- diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active

# Metabolic_Enzyme_18_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_18_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_18_Signals:
1-24

# Metabolic_Enzyme_18_Transmembrane_Regions:
495-517

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_18_GenBank_ID_Protein:
13603476

# Metabolic_Enzyme_18_SwissProt_ID:
UDB28_HUMAN (Q9BY64)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
UGT2B28

# Metabolic_Enzyme_18_Geneatlas_id:
UGT2B28

# Metabolic_Enzyme_18_hgnc_id:
HGNC:13479

# Metabolic_Enzyme_18_PDB_ID:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Microsome

# Metabolic_Enzyme_18_Gene_Sequence:
>1590 bp
ATGGCTCTGAAGTGGACTTCAGTTCTTCTGCTGATACATCTCGGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGACCGGTGAATACAGCCATTGGATGAATATGAAG
ACAATCCTGAAAGAGCTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAATGACGCATTCACTCTTAAACTCGAAGTTTATCCTACATCT
TTAACTAAAACTGAATTTGAGAATATCATCATGCAACAGGTTAAGAGATGGTCAGACATT
CAAAAAGATAGCTTTTGGTTATATTTTTCACAAGAACAAGAAATCCTGTGGGAATTTCAT
GACATATTTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAAGTTATGAAAAAACTA
CAAGAGTCAAGATTTGACATCATTTTTGCAGATGCTTTTTTTCCTTGTGGTGAGCTGCTG
GCTGCGCTACTTAACATACCGTTTGTGTACAGTCTCTGCTTCACTCCTGGCTACACAATT
GAAAGGCACAGTGGAGGACTGATTTTCCCTCCTTCCTACATACCTGTTGTTATGTCAAAA
TTAAGTGATCAAATGACTTTCATGGAGAGGGTAAAAAACATGATCTATGTGCTTTATTTT
GACTTTTGGTTCCAAATGTGTGATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTA
GGAAGACCCACTACCTTATTTGAGACAATGGGGAAAGCTGACATATGGCTTATGCGAAAC
TCCTGGAGTTTTCAATTTCCTCATCCATTCTTACCAAACATTGATTTTGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAATTTGTACAGAGCTCTGGT
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAGTGATAAGTAACATGACAGCAGAAAGG
GCCAACGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATGCCTTAGGTCTCAATACTCGGCTGTATAAGTGGATACCCCAGAAT
GACCTTCTAGGTCTTCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATGAGGCAATCTACCATGGGATCCCTATGGTAGGCATTCCATTGTTTTGGGATCAACCT
GATAACATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGACTGGACTTCCACACAATG
TCGAGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTCATATAAAGAG
AATGTTATGAAATTATCAATAATTCAACATGATCAACCAGTAAAGCCCCTGCATCGAGCA
GTCTTCTGGATTGAATTTGTGATGTGCCACAAAGGAGCCAAACACCTTCGAGTTGCAGCC
CGTGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTTCTGCTGGCCTGT
GTGGCAACTGTGATATTTGTCGTCACAAAGTTTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGGGAAGAAGGGAAAAAGAGATTAG

# Metabolic_Enzyme_18_GenBank_ID_Gene:
AF177272

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_18_Locus:
4q13.2

# Metabolic_Enzyme_18_SNPs:
rs4235127; rs4260604; rs4386668; rs11726210; rs10002503; rs4235126; rs3901337; rs4260603; rs10008843; rs4694712; rs4301173; rs4694711; rs2132039; rs9997242; rs4260602; rs4235125; rs4694713; rs7686786; rs10000077; rs7437560; rs7681187; rs10023367; rs7657406; rs41292949; rs6843900; rs6828191; rs41292951; rs10013145; rs7689398; rs41292341; rs13139691; rs13138824; rs4569811; rs6827801; rs34313836; rs5004177; rs28376412; rs13108235; rs5004180; rs4295327; rs4568294; rs4450998; rs33966513; rs5004176; rs35191928; rs13107778; rs4345242; rs34549399; rs4495113; rs5004183; rs41292945; rs41292947; rs35437714; rs35925451; rs13146763; rs28447469; rs35059283; rs5004182; rs7435249; rs5004175; rs5859170; rs4515230; rs6840320; rs35572829; rs5004178; rs5004179; rs4597901; rs41292339; rs5004181; rs13116501; rs10011666; rs41292343; rs7657045; rs13124875; rs9991645; rs35680160; rs6600920

# Metabolic_Enzyme_18_General_References:
11300766

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5974

# Metabolic_Enzyme_19_Name:
Flavin reductase

# Metabolic_Enzyme_19_Synonyms:
FR; NADPH-dependent diaphorase; NADPH-flavin reductase; FLR; Biliverdin reductase B; BVR-B; Biliverdin-IX beta-reductase; Green heme-binding protein; GHBP

# Metabolic_Enzyme_19_Gene_Name:
BLVRB

# Metabolic_Enzyme_19_Protein_Sequence:
>Flavin reductase
MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAAD
VDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTK
VPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHD
LGHFMLRCLTTDEYDGHSTYPSHQYQ

# Metabolic_Enzyme_19_Number_of_Residues:
206

# Metabolic_Enzyme_19_Molecular_Weight:
22120

# Metabolic_Enzyme_19_Theoretical_pI:
7.76

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide-sugar metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_19_Specific_Function:
Catalyzes electron transfer from reduced pyridine nucleotides to flavins as well as methylene blue, pyrroloquinoline quinone, riboflavin, or methemoglobin. Possible role in protecting cells from oxidative damage or in regulating iron metabolism. In the liver, converts biliverdin to bilirubin

# Metabolic_Enzyme_19_Pathway:
map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_19_Reaction:
reduced riboflavin + NADP+ = riboflavin + NADPH + H+

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF01370:Epimerase

# Metabolic_Enzyme_19_Signals:
None

# Metabolic_Enzyme_19_Transmembrane_Regions:
None

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 1.5.1.30;EC 1.3.1.24

# Metabolic_Enzyme_19_GenBank_ID_Protein:
1384068

# Metabolic_Enzyme_19_SwissProt_ID:
BLVRB_HUMAN (P30043)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
BLVRB

# Metabolic_Enzyme_19_Geneatlas_id:
BLVRB

# Metabolic_Enzyme_19_hgnc_id:
HGNC:1063

# Metabolic_Enzyme_19_PDB_ID:
1HE5

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Cytoplasm (Potential)

# Metabolic_Enzyme_19_Gene_Sequence:
>621 bp
ATGGCCGTCAAGAAGATCGCGATCTTCGGCGCCACTGGCCAGACCGGGCTCACCACCCTG
GCGCAGGCGGTGCAAGCAGGTTACGAAGTGACAGTGCTGGTGCGGGACTCCTCCAGGCTG
CCATCAGAGGGGCCCCGGCCGGCCCACGTGGTAGTGGGAGATGTTCTGCAGGCAGCCGAT
GTGGACAAGACCGTGGCTGGGCAGGACGCTGTCATCGTGCTGCTGGGCACCCGCAATGAC
CTCAGTCCCACGACAGTGATGTCCGAGGGCGCCCGGAACATTGTGGCAGCCATGAAGGCT
CATGGTGTGGACAAGGTCGTGGCCTGCACCTCGGCTTTCCTGCTCTGGGACCCTACCAAG
GTGCCCCCACGACTGCAGGCTGTGACTGATGACCACATCCGGATGCACAAGGTGCTGCGG
GAATCAGGCCTGAAGTACGTGGCTGTGATGCCGCCACACATAGGAGACCAGCCACTAACT
GGGGCGTACACAGTGACCCTGGATGGACGAGGGCCCTCAAGGGTCATCTCCAAACATGAC
CTGGGCCATTTCATGCTGCGCTGCCTCACCACCGATGAGTACGACGGACACAGCACCTAC
CCCTCCCACCAGTACCAGTAG

# Metabolic_Enzyme_19_GenBank_ID_Gene:
D26308

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_19_Locus:
19q13.1-q13.2

# Metabolic_Enzyme_19_SNPs:
rs1675404; rs1061197; rs268693; rs268692; rs268694; rs12459890; rs2169275; rs10421779; rs7255928; rs2613843; rs376112; rs9749496; rs10439101; rs41357045; rs12460618; rs268697; rs12981511; rs10439102; rs4803339; rs268696; rs10425814; rs268695; rs12460634; rs11878466; rs185593; rs268688; rs3745207; rs1804002; rs11547746; rs10281; rs1061340; rs7257546; rs7507689; rs34252952; rs34984704; rs36096038; rs28529139; rs35610866; rs10418696; rs35562498; rs35624785; rs34827058; rs34288924; rs35566164; rs34524101; rs28621979; rs4803340; rs12982125; rs426970; rs752212; rs2126121; rs28427504; rs12975787; rs28608147; rs34210692; rs4802078; rs444241; rs10698880; rs1058041; rs11667745; rs174865; rs183852; rs2168652; rs2368579; rs268690; rs268691; rs2887292; rs34004825; rs35314597; rs35754989; rs3745205; rs3745208; rs3760638; rs4803338; rs7259644

# Metabolic_Enzyme_19_General_References:
8117274; 8799475; 8280170; 7929092; 1286669; 8313871; 8687377; 11224564

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
7200

# Metabolic_Enzyme_20_Name:
Prothrombin precursor

# Metabolic_Enzyme_20_Synonyms:
Coagulation factor II[Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]

# Metabolic_Enzyme_20_Gene_Name:
F2

# Metabolic_Enzyme_20_Protein_Sequence:
>Prothrombin precursor
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE

# Metabolic_Enzyme_20_Number_of_Residues:
622

# Metabolic_Enzyme_20_Molecular_Weight:
70037

# Metabolic_Enzyme_20_Theoretical_pI:
5.70

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  thrombin activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
 ||
>>>
Process:  organismal physiological process
Process:  regulation of body fluids
Process:  hemostasis
Process:  blood coagulation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  extracellular region

# Metabolic_Enzyme_20_General_Function:
Not Available

# Metabolic_Enzyme_20_Specific_Function:
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C

# Metabolic_Enzyme_20_Pathway:
Not Available

# Metabolic_Enzyme_20_Reaction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00594:Gla;
PF00051:Kringle;
PF00089:Trypsin

# Metabolic_Enzyme_20_Signals:
1-24

# Metabolic_Enzyme_20_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 3.4.21.5

# Metabolic_Enzyme_20_GenBank_ID_Protein:
339641

# Metabolic_Enzyme_20_SwissProt_ID:
THRB_HUMAN (P00734)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
F2

# Metabolic_Enzyme_20_Geneatlas_id:
F2

# Metabolic_Enzyme_20_hgnc_id:
HGNC:3535

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_20_Gene_Sequence:
>1869 bp
ATGGCGCACGTCCGAGGCTTGCAGCTGCCTGGCTGCCTGGCCCTGGCTGCCCTGTGTAGC
CTTGTGCACAGCCAGCATGTGTTCCTGGCTCCTCAGCAAGCACGGTCGCTGCTCCAGCGG
GTCCGGCGAGCCAACACCTTCTTGGAGGAGGTGCGCAAGGGCAACCTAGAGCGAGAGTGC
GTGGAGGAGACGTGCAGCTACGAGGAGGCCTTCGAGGCTCTGGAGTCCTCCACGGCTACG
GATGTGTTCTGGGCCAAGTACACAGCTTGTGAGACAGCGAGGACGCCTCGAGATAAGCTT
GCTGCATGTCTGGAAGGTAACTGTGCTGAGGGTCTGGGTACGAACTACCGAGGGCATGTG
AACATCACCCGGTCAGGCATTGAGTGCCAGCTATGGAGGAGTCGCTACCCACATAAGCCT
GAAATCAACTCCACTACCCATCCTGGGGCCGACCTACAGGAGAATTTCTGCCGCAACCCC
GACAGCAGCACCACGGGACCCTGGTGCTACACTACAGACCCCACCGTGAGGAGGCAGGAA
TGCAGCATCCCTGTCTGTGGCCAGGATCAAGTCACTGTAGCGATGACTCCACGCTCCGAA
GGCTCCAGTGTGAATCTGTCACCTCCATTGGAGCAGTGTGTCCCTGATCGGGGGCAGCAG
TACCAGGGGCGCCTGGCGGTGACCACACATGGGCTCCCCTGCCTGGCCTGGGCCAGCGCA
CAGGCCAAGGCCCTGAGCAAGCACCAGGACTTCAACTCAGCTGTGCAGCTGGTGGAGAAC
TTCTGCCGCAACCCAGACGGGGATGAGGAGGGCGTGTGGTGCTATGTGGCCGGGAAGCCT
GGCGACTTTGGGTACTGCGACCTCAACTATTGTGAGGAGGCCGTGGAGGAGGAGACAGGA
GATGGGCTGGATGAGGACTCAGACAGGGCCATCGAAGGGCGTACCGCCACCAGTGAGTAC
CAGACTTTCTTCAATCCGAGGACCTTTGGCTCGGGAGAGGCAGACTGTGGGCTGCGACCT
CTGTTCGAGAAGAAGTCGCTGGAGGACAAAACCGAAAGAGAGCTCCTGGAATCCTACATC
GACGGGCGCATTGTGGAGGGCTCGGATGCAGAGATCGGCATGTCACCTTGGCAGGTGATG
CTTTTCCGGAAGAGTCCCCAGGAGCTGCTGTGTGGGGCCAGCCTCATCAGTGACCGCTGG
GTCCTCACCGCCGCCCACTGCCTCCTGTACCCGCCCTGGGACAAGAACTTCACCGAGAAT
GACCTTCTGGTGCGCATTGGCAAGCACTCCCGCACAAGGTACGAGCGAAACATTGAAAAG
ATATCCATGTTGGAAAAGATCTACATCCACCCCAGGTACAACTGGCGGGAGAACCTGGAC
CGGGACATTGCCCTGATGAAGCTGAAGAAGCCTGTTGCCTTCAGTGACTACATTCACCCT
GTGTGTCTGCCCGACAGGGAGACGGCAGCCAGCTTGCTCCAGGCTGGATACAAGGGGCGG
GTGACAGGCTGGGGCAACCTGAAGGAGACGTGGACAGCCAACGTTGGTAAGGGGCAGCCC
AGTGTCCTGCAGGTGGTGAACCTGCCCATTGTGGAGCGGCCGGTCTGCAAGGACTCCACC
CGGATCCGCATCACTGACAACATGTTCTGTGCTGGTTACAAGCCTGATGAAGGGAAACGA
GGGGATGCCTGTGAAGGTGACAGTGGGGGACCCTTTGTCATGAAGAGCCCCTTTAACAAC
CGCTGGTATCAAATGGGCATCGTCTCATGGGGTGAAGGCTGTGACCGGGATGGGAAATAT
GGCTTCTACACACATGTGTTCCGCCTGAAGAAGTGGATACAGAAGGTCATTGATCAGTTT
GGAGAGTAG

# Metabolic_Enzyme_20_GenBank_ID_Gene:
M17262

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_20_Locus:
11p11-q12

# Metabolic_Enzyme_20_SNPs:
rs5896; rs5898; rs3136452; rs3136532; rs5899; rs3136457; rs3136449; rs3136516; rs2282686; rs2070851; rs3136460; rs3136447; rs3136478; rs3136441; rs3136435; rs2070852; rs2282687; rs3136520; rs3136512; rs3136509; rs3136474; rs3136434; rs3136471; rs3136485; rs3136439; rs3136497; rs3136433; rs3136505; rs3136455; rs3136484; rs3136446; rs3136472; rs3136431; rs2070850; rs10838616; rs3136456; rs3136479; rs3136443; rs3136476; rs3136500; rs12574714; rs3136482; rs3136495; rs3136503; rs3136483; rs3136521; rs3136487; rs3136458; rs3136491; rs1799867; rs3136504; rs3136513; rs3136436; rs3136469; rs3136448; rs3136496; rs3136468; rs3136489; rs3136490; rs3136459; rs3136438; rs3136467; rs3136507; rs3136499; rs3136463; rs3136515; rs3136506; rs3136480; rs3136481; rs3136440; rs3136524; rs3136519; rs3136430; rs3136518; rs17854684; rs5897; rs1130873; rs5900; rs1799963; rs3136508; rs35768741; rs3136530; rs3136501; rs3136445; rs3136461; rs3136531; rs3136492; rs3891193; rs3136525; rs3136466; rs3136527; rs34428021; rs3136437; rs12787268; rs3136454; rs3136528; rs35690173; rs3136477; rs3136488; rs34747958; rs3136442; rs34204052; rs11038981; rs3926328; rs3136465; rs34647507; rs3136493; rs3136529; rs11038980; rs3136522; rs7123803; rs17847082; rs3136464; rs3136514; rs3926329; rs3136502; rs34284995; rs3136511; rs3136486; rs3136494; rs3136444; rs3136523; rs36050035; rs35150107; rs1129439; rs34296052; rs3136498; rs11438724; rs3136526; rs3136510; rs35817575; rs4752930; rs3136517; rs9794941; rs41275180; rs10838614; rs11038975; rs11038977; rs11038983; rs11038984; rs1130904; rs11604876; rs4076557; rs7938264

# Metabolic_Enzyme_20_General_References:
2825773; 6305407; 266717; 873923; 3759958; 2583108; 2374926; 8071320; 9214615; 10051558; 3771562; 7792730; 1421398; 7865694; 3242619; 2719946; 1354985; 3567158; 3801671; 1349838; 6405779; 10391209

# Metabolic_Enzyme_20_References:
16837801; 17006987; 17022748; 17058104

# Metabolic_Enzyme_21_ID:
5331

# Metabolic_Enzyme_21_Name:
Alkaline phosphatase, placental-like precursor

# Metabolic_Enzyme_21_Synonyms:
Alkaline phosphatase Nagao isozyme; Germ-cell alkaline phosphatase; GCAP; PLAP-like; ALP-1

# Metabolic_Enzyme_21_Gene_Name:
ALPPL2

# Metabolic_Enzyme_21_Protein_Sequence:
>Alkaline phosphatase, placentallike precursor
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLG
DGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLC
GVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDY
SQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRD
STLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERA
GQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL
KDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHV
MAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP

# Metabolic_Enzyme_21_Number_of_Residues:
532

# Metabolic_Enzyme_21_Molecular_Weight:
57378

# Metabolic_Enzyme_21_Theoretical_pI:
6.31

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_21_Specific_Function:
A phosphate monoester + H(2)O = an alcohol + phosphate

# Metabolic_Enzyme_21_Pathway:
map00361  gamma-Hexachlorocyclohexane degradation;
 map00790  Folate biosynthesis

# Metabolic_Enzyme_21_Reaction:
A phosphate monoester + H2O = an alcohol + phosphate

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF00245:Alk_phosphatase

# Metabolic_Enzyme_21_Signals:
1-19

# Metabolic_Enzyme_21_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 3.1.3.1

# Metabolic_Enzyme_21_GenBank_ID_Protein:
178428

# Metabolic_Enzyme_21_SwissProt_ID:
PPBN_HUMAN (P10696)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
ALPPL2

# Metabolic_Enzyme_21_Geneatlas_id:
ALPPL2

# Metabolic_Enzyme_21_hgnc_id:
HGNC:441

# Metabolic_Enzyme_21_PDB_ID:
1EW2

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Metabolic_Enzyme_21_Gene_Sequence:
>1599 bp
ATGCAGGGGCCCTGGGTGCTGCTCCTGCTGGGCCTGAGGCTACAGCTCTCCCTGGGCATC
ATCCCAGTTGAGGAGGAGAACCCGGACTTCTGGAACCGCCAGGCAGCCGAGGCCCTGGGT
GCCGCCAAGAAGCTGCAGCCTGCACAGACAGCCGCCAAGAACCTCATCATGTTCCTGGGT
GACGGGATGGGGGTGTCTACGGTGACAGCTGCCAGGATCCTAAAAGGGCAGAAGAAGGAC
AAACTGGGGCCTGAGACCTTCCTGGCCATGGACCGCTTCCCGTACGTGGCTCTGTCCAAG
ACATACAGTGTAGACAAGCATGTGCCAGACAGTGGAGCCACAGCCACGGCCTACCTGTGC
GGGGTCAAGGGCAACTTCCAGACCATTGGCTTGAGTGCAGCCGCCCGCTTTAACCAGTGC
AACACGACACGCGGCAACGAGGTCATCTCCGTGGTGAATCGGGCCAAGAAAGCAGGAAAG
TCAGTGGGAGTGGTAACCACCACACGGGTGCAGCATGCCTCGCCAGCCGGCACCTACGCC
CACACGGTGAACCGCAACTGGTACTCGGATGCCGACGTGCCTGCCTCGGCCCGCCAGGAG
GGGTGCCAGGACATCGCCACGCAGCTCATCTCCAACATGGACATTGATGTGATCCTAGGT
GGAGGCCGAAAGTACATGTTTCCCATGGGGACCCCAGACCCTGAGTACCCAGATGACTAC
AGCCAAGGTGGGACCAGGCTGGACGGGAAGAATCTGGTGCAGGAATGGCTGGCGAAGCAC
CAGGGTGCCCGGTACGTGTGGAACCGCACTGAGCTCCTGCAGGCTTCCCTGGACCCGTCT
GTGACCCATCTCATGGGTCTCTTTGAGCCTGGAGACATGAAATACGAGATCCACCGAGAC
TCCACACTGGACCCCTCCCTGATGGAGATGACAGAGGCTGCCCTGCTCCTGCTGAGCAGG
AACCCCCGCGGCTTCTTCCTCTTCGTGGAGGGTGGTCGCATCGACCATGGTCATCATGAA
AGCAGGGCTTACCGGGCACTGACTGAGACGATCATGTTCGACGACGCCATTGAGAGGGCG
GGCCAGCTCACCAGCGAGGAGGACACGCTGAGCCTCGTCACTGCCGACCACTCCCACGTC
TTCTCCTTCGGAGGCTACCCCCTGCGAGGGAGCTCCATCTTCGGGCTGGCCCCTGGCAAG
GCCCGGGACAGGAAGGCCTACACGGTCCTCCTATACGGAAACGGTCCAGGCTATGTGCTC
AAGGACGGCGCCCGGCCGGATGTTACGGAGAGCGAGAGCGGGAGCCCCGAGTATCGGCAG
CAGTCAGCAGTGCCCCTGGACGGAGAGACCCACGCAGGCGAGGACGTGGCGGTGTTCGCG
CGCGGCCCGCAGGCGCACCTGGTTCACGGCGTGCAGGAGCAGACCTTCATAGCGCACGTC
ATGGCCTTCGCCGCCTGCCTGGAGCCCTACACCGCCTGCGACCTGGCGCCCCCCGCCGGC
ACCACCGACGCCGCGCACCCGGGGCCGTCCGTGGTCCCCGCGTTGCTTCCTCTGCTGGCA
GGGACCTTGCTGCTGCTGGGGACGGCCACTGCTCCCTGA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
J03252

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_21_Locus:
2q37

# Metabolic_Enzyme_21_SNPs:
rs1048983; rs1048999; rs17416141; rs2090543; rs1048997; rs1009934; rs2678519; rs2697781; rs3828248; rs3828254; rs2697767; rs3828249; rs2697768; rs1048995; rs16836187; rs3116148; rs1130334; rs41265119; rs41265117; rs3111340; rs41265115; rs1049002; rs1049001; rs3189080; rs3924351; rs1049003; rs1130348; rs1130351; rs3924352; rs3189077; rs6728119; rs2091555; rs2945420; rs2678518; rs41265113; rs3111339; rs3833560; rs2678517; rs2945421; rs41265111; rs2091556; rs3830644; rs3828251; rs3828253; rs2697769; rs11363206; rs3828250; rs3828252; rs11678251; rs1001868; rs10195918; rs13002718; rs13003189; rs13412526; rs1878691; rs2082841; rs2082842; rs2139026; rs2139027; rs2573208; rs2573209; rs2697766; rs2697790; rs2697791; rs2697792; rs2697793; rs2741321; rs2853380; rs732581; rs744873; rs744874; rs790050; rs790051

# Metabolic_Enzyme_21_General_References:
2834730; 2745460; 2297757; 2162249; 3387245

# Metabolic_Enzyme_21_References:
15700767; 15756803

# Metabolic_Enzyme_22_ID:
6131

# Metabolic_Enzyme_22_Name:
Alanine aminotransferase 1

# Metabolic_Enzyme_22_Synonyms:
ALT1; Glutamic--pyruvic transaminase 1; GPT 1; Glutamic--alanine transaminase 1

# Metabolic_Enzyme_22_Gene_Name:
GPT

# Metabolic_Enzyme_22_Protein_Sequence:
>Alanine aminotransferase 1
MASSTGDRSQAVRHGLRAKVLTLDGMNPRVRRVEYAVRGPIVQRALELEQELRQGVKKPF
TEVIRANIGD
AQAMGQRPITFLRQVLALCVNPDLLSSPNFPDDAKKRAERILQACGGHS
LGAYSVSSGIQLIREDVARYI
ERRDGGIPADPNNVFLSTGASDAIVTVLKLLVAGEGHT
RTGVLIPIPQYPLYSATLAELGAVQVDYYLDE
ERAWALDVAELHRALGQARDHCRPRAL
CVINPGNPTGQVQTRECIEAVIRFAFEERLFLLADEVYQDNVY
AAGSQFHSFKKVLMEM
GPPYAGQQELASFHSTSKGYMGECGFRGGYVEVVNMDAAVQQQMLKLMSVRLCP
PVPGQ
ALLDLVVSPPAPTDPSFAQFQAEKQAVLAELAAKAKLTEQVFNEAPGISCNPVQGAMYSF
PRVQL
PPRAVERAQELGLAPDMFFCLRLLEETGICVVPGSGFGQREGTYHFRMTILPPL
EKLRLLLEKLSRFHAK
FTLEYS

# Metabolic_Enzyme_22_Number_of_Residues:
496

# Metabolic_Enzyme_22_Molecular_Weight:
54638

# Metabolic_Enzyme_22_Theoretical_pI:
7.20

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-sulfur lyase activity
Function:  1-aminocyclopropane-1-carboxylate synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_22_Specific_Function:
Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles

# Metabolic_Enzyme_22_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00710  Carbon fixation

# Metabolic_Enzyme_22_Reaction:
L-alanine + 2-oxoglutarate = pyruvate + L-glutamate

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_22_Signals:
None

# Metabolic_Enzyme_22_Transmembrane_Regions:
None

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 2.6.1.2

# Metabolic_Enzyme_22_GenBank_ID_Protein:
1763096

# Metabolic_Enzyme_22_SwissProt_ID:
ALAT1_HUMAN (P24298)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
GPT

# Metabolic_Enzyme_22_Geneatlas_id:
GPT

# Metabolic_Enzyme_22_hgnc_id:
HGNC:4552

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_22_Gene_Sequence:
>1491 bp

ATGGCCTCGAGCACAGGTGACCGGAGCCAGGCGGTGAGGCATGGACTGAGGGCGAAGGT
GCTGACGCTGG
ACGGCATGAACCCGCGTGTGCGGAGAGTGGAGTACGCAGTGCGTGGCC
CCATAGTGCAGCGAGCCTTGGA
GCTGGAGCAGGAGCTGCGCCAGGGTGTGAAGAAGCCT
TTCACCGAGGTCATCCGTGCCAACATCGGGGAC
GCACAGGCTATGGGGCAGAGGCCCAT
CACCTTCCTGCGCCAGGTCTTGGCCCTCTGTGTTAACCCTGATC
TTCTGAGCAGCCCCA
ACTTCCCTGACGATGCCAAGAAAAGGGCGGAGCGCATCTTGCAGGCGTGTGGGGG
CCAC
AGTCTGGGGGCCTACAGCGTCAGCTCCGGCATCCAGCTGATCCGGGAGGACGTGGCGCGG
TACATT
GAGAGGCGTGACGGAGGCATCCCTGCGGACCCCAACAACGTCTTCCTGTCCAC
AGGGGCCAGCGATGCCA
TCGTGACGGTGCTGAAGCTGCTGGTGGCCGGCGAGGGCCACA
CACGCACGGGTGTGCTCATCCCCATCCC
CCAGTACCCACTCTACTCGGCCACGCTGGCA
GAGCTGGGCGCAGTGCAGGTGGATTACTACCTGGACGAG
GAGCGTGCCTGGGCGCTGGA
CGTGGCCGAGCTTCACCGTGCACTGGGCCAGGCGCGTGACCACTGCCGCC
CTCGTGCGC
TCTGTGTCATCAACCCTGGCAACCCCACCGGGCAGGTGCAGACCCGCGAGTGCATCGAGG
C
CGTGATCCGCTTCGCCTTCGAAGAGCGGCTCTTTCTGCTGGCGGACGAGGTGTACCAG
GACAACGTGTAC
GCCGCGGGTTCGCAGTTCCACTCATTCAAGAAGGTGCTCATGGAGAT
GGGGCCGCCCTACGCCGGGCAGC
AGGAGCTTGCCTCCTTCCACTCCACCTCCAAGGGCT
ACATGGGCGAGTGCGGGTTCCGCGGCGGCTATGT
GGAGGTGGTGAACATGGACGCTGCA
GTGCAGCAGCAGATGCTGAAGCTGATGAGTGTGCGGCTGTGCCCG
CCGGTGCCAGGACA
GGCCCTGCTGGACCTGGTGGTCAGCCCGCCCGCGCCCACCGACCCCTCCTTTGCGC
AGT
TCCAGGCTGAGAAGCAGGCAGTGCTGGCAGAGCTGGCGGCCAAGGCCAAGCTCACCGAGC
AGGTCTT
CAATGAGGCTCCTGGCATCAGCTGCAACCCAGTGCAGGGCGCCATGTACTCC
TTCCCGCGCGTGCAGCTG
CCCCCGCGGGCGGTGGAGCGCGCTCAGGAGCTGGGCCTGGC
CCCCGATATGTTCTTCTGCCTGCGCCTCC
TGGAGGAGACCGGCATCTGCGTGGTGCCAG
GGAGCGGCTTTGGGCAGCGGGAAGGCACCTACCACTTCCG
GATGACCATTCTGCCCCCC
TTGGAGAAACTGCGGCTGCTGCTGGAGAAGCTGAGCAGGTTCCATGCCAAG
TTCACCCT
CGAGTACTCCTGA

# Metabolic_Enzyme_22_GenBank_ID_Gene:
U70732

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_22_Locus:
8q24.3

# Metabolic_Enzyme_22_SNPs:
Not Available

# Metabolic_Enzyme_22_General_References:
9119391; 1931970; 11863375

# Metabolic_Enzyme_22_References:
15621157; 16317669; 16824075

# Metabolic_Enzyme_23_ID:
5383

# Metabolic_Enzyme_23_Name:
Heme oxygenase 2

# Metabolic_Enzyme_23_Synonyms:
HO-2

# Metabolic_Enzyme_23_Gene_Name:
HMOX2

# Metabolic_Enzyme_23_Protein_Sequence:
>Heme oxygenase 2
MSAEVETSEGVDESEKKNSGALEKENQMRMADLSELLKEGTKEAHDRAENTQFVKDFLKG
NIKKELFKLATTALYFTYSALEEEMERNKDHPAFAPLYFPMELHRKEALTKDMEYFFGEN
WEEQVQCPKAAQKYVERIHYIGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPST
GEGTQFYLFENVDNAQQFKQLYRARMNALDLNMKTKERIVEEANKAFEYNMQIFNELDQA
GSTLARETLEDGFPVHDGKGDMRKCPFYAAEQDKGALEGSSCPFRTAMAVLRKPSLQFIL
AAGVALAAGLLAWYYM

# Metabolic_Enzyme_23_Number_of_Residues:
316

# Metabolic_Enzyme_23_Molecular_Weight:
36033

# Metabolic_Enzyme_23_Theoretical_pI:
5.09

# Metabolic_Enzyme_23_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  heme oxygenase (decyclizing) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  heterocycle metabolism
Process:  porphyrin metabolism
Process:  heme metabolism
Process:  heme oxidation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_23_General_Function:
Not Available

# Metabolic_Enzyme_23_Specific_Function:
Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter

# Metabolic_Enzyme_23_Pathway:
map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_23_Reaction:
heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF01126:Heme_oxygenase

# Metabolic_Enzyme_23_Signals:
None

# Metabolic_Enzyme_23_Transmembrane_Regions:
296-315

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 1.14.99.3

# Metabolic_Enzyme_23_GenBank_ID_Protein:
443771

# Metabolic_Enzyme_23_SwissProt_ID:
HMOX2_HUMAN (P30519)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
HMOX2

# Metabolic_Enzyme_23_Geneatlas_id:
HMOX2

# Metabolic_Enzyme_23_hgnc_id:
HGNC:5014

# Metabolic_Enzyme_23_PDB_ID:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Microsome

# Metabolic_Enzyme_23_Gene_Sequence:
>951 bp
ATGTCAGCGGAAGTGGAAACCTCAGAGGGGGTAGACGAGTCAGAAAAAAAGAACTCTGGG
GCCCTAGAAAAGGAGAACCAAATGAGAATGGCTGACCTCTCGGAGCTCCTGAAGGAAGGG
ACCAAGGAAGCACACGACCGGGCAGAAAACACCCAGTTTGTCAAGGACTTCTTGAAAGGC
AACATTAAGAAGGAGCTGTTTAAGCTGGCCACCACGGCACTTTACTTCACATACTCAGCC
CTCGAGGAGGAAATGGAGCGCAACAAGGACCATCCAGCCTTTGCCCCTTTGTACTTCCCC
ATGGAGCTGCACCGGAAGGAGGCGCTGACCAAGGACATGGAGTATTTCTTTGGTGAAAAC
TGGGAGGAGCAGGTGCAGTGCCCCAAGGCTGCCCAGAAGTACGTGGAGCGGATCCACTAC
ATAGGGCAGAACGAGCCGGAGCTACTGGTGGCCCATGCATACACCCGCTACATGGGGGAT
CTCTCGGGGGGCCAGGTGCTGAAGAAGGTGGCCCAGCGAGCACTGAAACTCCCCAGCACA
GGGGAAGGGACCCAGTTCTACCTGTTTGAGAATGTGGACAATGCCCAGCAGTTCAAGCAG
CTCTACCGGGCCAGGATGAACGCCCTGGACCTGAACATGAAGACCAAAGAGAGGATCGTG
GAGGAGGCCAACAAGGCTTTTGAGTATAACATGCAGATATTCAATGAACTGGACCAGGCC
GGCTCCACACTGGCCAGAGAGACCTTGGAGGATGGGTTCCCTGTACACGATGGGAAAGGA
GACATGCGTAAATGCCCTTTCTACGCTGCTGAACAAGACAAAGGTGCCCTGGAGGGCAGC
AGCTGTCCCTTCCGAACAGCTATGGCTGTGCTGAGGAAGCCCAGCCTCCAGTTCATCCTG
GCCGCTGGTGTGGCCCTAGCTGCTGGACTCTTGGCCTGGTACTACATGTGA

# Metabolic_Enzyme_23_GenBank_ID_Gene:
D21243

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_23_Locus:
16p13.3

# Metabolic_Enzyme_23_SNPs:
rs17137094; rs25686; rs1362626; rs1362627; rs2160567; rs4786501; rs8055559; rs13335503; rs9929475; rs7404191; rs8047271; rs4238849; rs11076834; rs6500610; rs11639998; rs4785968; rs11076833; rs8057858; rs3789038; rs8050010; rs9934267; rs8063084; rs8053770; rs10500325; rs7192051; rs17137075; rs9921781; rs9302781; rs9936357; rs17761816; rs7191664; rs7195782; rs11866840; rs11643057; rs4785969; rs8063956; rs9938228; rs8051695; rs11863671; rs8048958; rs7194436; rs12443748; rs8046295; rs17881650; rs17137089; rs9934024; rs11076835; rs17880819; rs8058798; rs17883666; rs17880954; rs17880631; rs7202353; rs7200280; rs17885807; rs4786502; rs7199029; rs17886618; rs17884379; rs17881736; rs17883218; rs7194923; rs11645519; rs13338199; rs17880489; rs17883698; rs17883481; rs17879252; rs7201171; rs17761715; rs17885842; rs17880596; rs17883466; rs17881499; rs17882082; rs2270366; rs11860985; rs17137096; rs9923062; rs17881522; rs17884752; rs9925402; rs17878588; rs17884975; rs17883627; rs17880805; rs11542539; rs11542540; rs17884623; rs34975267; rs2404579; rs11542537; rs8045851; rs34550494; rs17881972; rs17884959; rs34750458; rs17879388; rs17878449; rs35583508; rs17884921; rs35499558; rs34478572; rs17887038; rs7204979; rs4785970; rs13334050; rs4786504; rs17885045; rs11647103; rs17882072; rs7200713; rs17883431; rs17881609; rs7195361; rs36062436; rs17883661; rs34970627; rs13331982; rs17881433; rs36203331; rs17881904; rs17886279; rs17881667; rs35022675; rs17884444; rs36021777; rs35152645; rs17885794; rs13330134; rs17878404; rs4786505; rs13330679; rs17880377; rs12596749; rs12448777; rs34314976; rs17887260; rs17882207; rs12598836; rs11542538; rs35532266; rs34376283; rs36017534; rs35490281; rs17886990; rs4786503; rs34636850; rs35433748; rs17884812; rs17886231; rs17884609; rs1345430; rs35341418; rs17883388; rs17881802; rs11644559; rs34938664; rs34672778; rs17884189; rs17881875; rs17882121; rs17884735; rs17884246; rs34845930; rs7206454; rs35467800; rs17884406; rs9925623; rs17880855; rs17884699; rs35332500; rs17880706; rs35695989; rs17878386; rs17886494; rs17884856; rs34500287; rs17881977; rs35267109; rs28567382; rs17878340; rs11861375; rs17885831; rs17882331; rs35235100; rs17883378; rs1051308; rs11076836; rs11076837; rs11557236; rs11862204; rs12102873; rs12446765; rs13333389; rs1362625; rs1477124; rs17137051; rs17137053; rs17137056; rs17137098; rs17887050; rs1861653; rs2058812; rs2270363; rs2270364; rs2270365; rs2270367; rs28445339; rs28576729; rs35956136; rs3747585; rs3761680; rs3761682; rs3919551; rs4785966; rs4786500; rs4786506; rs4786508; rs4786509; rs7665; rs7702; rs8129

# Metabolic_Enzyme_23_General_References:
7890772; 1575508

# Metabolic_Enzyme_23_References:
16181104

# Macromolecular_Interacting_Partner_1_ID:
7527

# Macromolecular_Interacting_Partner_1_Name:
Orphan nuclear receptor PXR

# Macromolecular_Interacting_Partner_1_Synonyms:
Pregnane X receptor; Orphan nuclear receptor PAR1; Steroid and xenobiotic receptor; SXR

# Macromolecular_Interacting_Partner_1_Gene_Name:
NR1I2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Orphan nuclear receptor 
PXRMEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMT
CEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEA
VEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGV
LSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIF
SLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETG
TWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVL
QHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDI
HPFATPLMQELFGITGS

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
434

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
49762

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
8.44

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Orphan receptor; its natural ligand is probably pregnane. Binds to a response element in the CYP3A4 and ABCB1/MDR1 genes promoter. Activates its expression in response to a wide variety of endobiotics and xenobiotics

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
3511138

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
PXR_HUMAN (O75469)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
NR1I2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
NR1I2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:7968

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1305 bp
CTGGAGGTGAGACCCAAAGAAAGCTGGAACCATGCTGACTTTGTACACTGTGAGGACACA
GAGTCTGTTCCTGGAAAGCCCAGTGTCAACGCAGATGAGGAAGTCGGAGGTCCCCAAATC
TGCCGTGTATGTGGGGACAAGGCCACTGGCTATCACTTCAATGTCATGACATGTGAAGGA
TGCAAGGGCTTTTTCAGGAGGGCCATGAAACGCAACGCCCGGCTGAGGTGCCCCTTCCGG
AAGGGCGCCTGCGAGATCACCCGGAAGACCCGGCGACAGTGCCAGGCCTGCCGCCTGCGC
AAGTGCCTGGAGAGCGGCATGAAGAAGGAGATGATCATGTCCGACGAGGCCGTGGAGGAG
AGGCGGGCCTTGATCAAGCGGAAGAAAAGTGAACGGACAGGGACTCAGCCACTGGGAGTG
CAGGGGCTGACAGAGGAGCAGCGGATGATGATCAGGGAGCTGATGGACGCTCAGATGAAA
ACCTTTGACACTACCTTCTCCCATTTCAAGAATTTCCGGCTGCCAGGGGTGCTTAGCAGT
GGCTGCGAGTTGCCAGAGTCTCTGCAGGCCCCATCGAGGGAAGAAGCTGCCAAGTGGAGC
CAGGTCCGGAAAGATCTGTGCTCTTTGAAGGTCTCTCTGCAGCTGCGGGGGGAGGATGGC
AGTGTCTGGAACTACAAACCCCCAGCCGACAGTGGCGGGAAAGAGATCTTCTCCCTGCTG
CCCCACATGGCTGACATGTCAACCTACATGTTCAAAGGCATCATCAGCTTTGCCAAAGTC
ATCTCCTACTTCAGGGACTTGCCCATCGAGGACCAGATCTCCCTGCTGAAGGGGGCCGCT
TTCGAGCTGTGTCAACTGAGATTCAACACAGTGTTCAACGCGGAGACTGGAACCTGGGAG
TGTGGCCGGCTGTCCTACTGCTTGGAAGACACTGCAGGTGGCTTCCAGCAACTTCTACTG
GAGCCCATGCTGAAATTCCACTACATGCTGAAGAAGCTGCAGCTGCATGAGGAGGAGTAT
GTGCTGATGCAGGCCATCTCCCTCTTCTCCCCAGACCGCCCAGGTGTGCTGCAGCACCGC
GTGGTGGACCAGCTGCAGGAGCAATTCGCCATTACTCTGAAGTCCTACATTGAATGCAAT
CGGCCCCAGCCTGCTCATAGGTTCTTGTTCCTGAAGATCATGGCTATGCTCACCGAGCTC
CGCAGCATCAATGCTCAGCACACCCAGCGGCTGCTGCGCATCCAGGACATACACCCCTTT
GCTACGCCCCTCATGCAGGAGTTGTTCGGCATCACAGGTAGCTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AF061056

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_1_Locus:
3q12-q13.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs1063955; rs35761343; rs12721612; rs2229856; rs2461823; rs2461821; rs7643645; rs1054190; rs2276706; rs3732360; rs3814055; rs6438550; rs2276705; rs1357459; rs3814058; rs6773295; rs2472672; rs1403526; rs3814057; rs3732359; rs3732358; rs4687886; rs2472678; rs1403527; rs2472671; rs4472074; rs4687884; rs4687887; rs12488820; rs4234666; rs10934498; rs2472670; rs6438549; rs2472677; rs4687885; rs6771638; rs2461818; rs1523127; rs6438545; rs2873951; rs11712211; rs2461817; rs10511395; rs1523130; rs4688040; rs2056530; rs16830505; rs2472675; rs2037548; rs13059232; rs2461820; rs1523129; rs6438548; rs6438547; rs3814056; rs1054191; rs6772976; rs2461831; rs4440154; rs9856637; rs1523128; rs12107248; rs7623520; rs2472673; rs7642839; rs1879997; rs7617259; rs4566573; rs2461822; rs10934499; rs2472668; rs2472676; rs12492296; rs9843562; rs9828996; rs13071341; rs6775566; rs13323135; rs9826476; rs1464602; rs11929668; rs6784598; rs1464603; rs2276707; rs2472680; rs1464601; rs11917714; rs3732357; rs2472682; rs6785049; rs2461824; rs2472681; rs2461816; rs2461825; rs3732356; rs1464600; rs11928828; rs940087; rs4688038; rs9859568; rs4687883; rs2461826; rs954356; rs12107259; rs9813490; rs4058490; rs35326198; rs36126391; rs35486268; rs36125293; rs17203264; rs3842689; rs36003854; rs10594686; rs9881496; rs4688041; rs1049525; rs13066380; rs35110581; rs34255376; rs35707807; rs13087843; rs2472674; rs3030845; rs35576922; rs4267673; rs34253854; rs34919701; rs35571335; rs11328453; rs1960022; rs11443946; rs34403319; rs35339162; rs11389476; rs34973302; rs41271397; rs35827866; rs35810054; rs11421631; rs34524182; rs34344833; rs28692786; rs35080422; rs13085558; rs11717763; rs34919105; rs35190493; rs4521275; rs35100139; rs5852228; rs34673274; rs2280566; rs13091204; rs10460826; rs2472683; rs10585009; rs2461832; rs34745714; rs35539946; rs11388198; rs2472679; rs3030842; rs9851439; rs2472669; rs34874198; rs4688039; rs6793724; rs11346739; rs34037717; rs3841391; rs35705339; rs34846354; rs35466282; rs35382764; rs3030846; rs13080715; rs11409387; rs35221555; rs10714748; rs11303804; rs35556391; rs35982683; rs35621359; rs35261172; rs6797879; rs12630636; rs2461815; rs41271399; rs34946686; rs6762873; rs33966885; rs11282244; rs4334674; rs954357; rs11926554; rs12721596; rs12721597; rs12721598; rs12721599; rs12721600; rs12721602; rs12721604; rs12721607; rs12721609; rs12721611; rs12721613; rs12721614; rs12721615; rs1581451; rs1608331; rs2037547; rs2873950; rs3732361; rs4261913; rs4331699; rs4331700; rs4688035; rs4688036; rs7643038; rs9821892; rs9832958; rs9837710; rs9843196

# Macromolecular_Interacting_Partner_1_General_References:
9727070; 9770465; 11668216; 9784494; 12606758; 11408620

# Macromolecular_Interacting_Partner_1_References:
15726644

# Macromolecular_Interacting_Partner_2_ID:
7551

# Macromolecular_Interacting_Partner_2_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_2_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_2_Locus:
6p21.3

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_2_References:
16182740; 16822952

# Macromolecular_Interacting_Partner_3_ID:
7556

# Macromolecular_Interacting_Partner_3_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_3_Signals:
1-18

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_3_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_3_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_3_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_3_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_3_References:
15700767; 15777743; 15846681; 16015688

# Macromolecular_Interacting_Partner_4_ID:
5430

# Macromolecular_Interacting_Partner_4_Name:
Heme oxygenase 1

# Macromolecular_Interacting_Partner_4_Synonyms:
HO-1

# Macromolecular_Interacting_Partner_4_Gene_Name:
HMOX1

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Heme oxygenase 1
MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVA
LEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHE
VGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQ
LYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRA
SNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
288

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
32819

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.68

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  heme oxygenase (decyclizing) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  heterocycle metabolism
Process:  porphyrin metabolism
Process:  heme metabolism
Process:  heme oxidation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed

# Macromolecular_Interacting_Partner_4_Pathway:
map00860  Porphyrin and chlorophyll metabolism

# Macromolecular_Interacting_Partner_4_Reaction:
heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF01126:Heme_oxygenase

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
265-287

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
EC 1.14.99.3

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
35173

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
HMOX1_HUMAN (P09601)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
HMOX1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
HMOX1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:5013

# Macromolecular_Interacting_Partner_4_PDB_ID:
1T5P

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Microsome

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>867 bp
ATGGAGCGTCCGCAACCCGACAGCATGCCCCAGGATTTGTCAGAGGCCCTGAAGGAGGCC
ACCAAGGAGGTGCACACCCAGGCAGAGAATGCTGAGTTCATGAGGAACTTTCAGAAGGGC
CAGGTGACCCGAGACGGCTTCAAGCTGGTGATGGCCTCCCTGTACCACATCTATGTGGCC
CTGGAGGAGGAGATTGAGCGCAACAAGGAGAGCCCAGTCTTCGCCCCTGTCTACTTCCCA
GAAGAGCTGCACCGCAAGGCTGCCCTGGAGCAGGACCTGGCCTTCTGGTACGGGCCCCGC
TGGCAGGAGGTCATCCCCTACACACCAGCCATGCAGCGCTATGTGAAGCGGCTCCACGAG
GTGGGGCGCACAGAGCCCGAGCTGCTGGTGGCCCACGCCTACACCCGCTACCTGGGTGAC
CTGTCTGGGGGCCAGGTGCTCAAAAAGATTGCCCAGAAAGCCCTGGACCTGCCCAGCTCT
GGCGAGGGCCTGGCCTTCTTCACCTTCCCCAACATTGCCAGTGCCACCAAGTTCAAGCAG
CTCTACCGCTCCCGCATGAACTCCCTGGAGATGACTCCCGCAGTCAGGCAGAGGGTGATA
GAAGAGGCCAAGACTGCGTTCCTGCTCAACATCCAGCTCTTTGAGGAGTTGCAGGAGCTG
CTGACCCATGACACCAAGGACCAGAGCCCCTCACGGGCACCAGGGCTTCGCCAGCGGGCC
AGCAACAAAGTGCAAGATTCTGCCCCCGTGGAGACTCCCAGAGGGAAGCCCCCACTCAAC
ACCCGCTCCCAGGCTCCGCTTCTCCGATGGGTCCTTACACTCAGCTTTCTGGTGGCGACA
GTTGCTGTAGGGCTTTATGCCATGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
X06985

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_4_Locus:
22q12|22q13.1

# Macromolecular_Interacting_Partner_4_SNPs:
rs2071747; rs9282702; rs5755713; rs11555832; rs9282701; rs8139532; rs8140370; rs5755720; rs5999815; rs8140669; rs11912889; rs6518952; rs9306300; rs5755719; rs3216831; rs9610292; rs5755718; rs2071748; rs17885185; rs5755717; rs2285112; rs5995100; rs2269533; rs11913097; rs5995099; rs17886055; rs16995662; rs5995097; rs7285877; rs2071749; rs2269534; rs17885522; rs12160711; rs17881086; rs5999816; rs17880614; rs2413346; rs4820192; rs8142390; rs17882597; rs17879082; rs5995098; rs9306301; rs5999814; rs9610291; rs9607267; rs5755716; rs17879606; rs11913209; rs17885902; rs17883018; rs5995101; rs9622194; rs17878790; rs17880294; rs17881147; rs17885925; rs2003038; rs17882565; rs2071746; rs9619536; rs3761439; rs17880288; rs12160039; rs17879895; rs5755712; rs17883752; rs9282700; rs35980144; rs11555830; rs11912348; rs17880056; rs5755721; rs36019273; rs35703925; rs36017314; rs35777199; rs5755715; rs17884268; rs13053677; rs17885296; rs12169444; rs12483783; rs17885538; rs28691814; rs9622192; rs12169485; rs35360540; rs17878771; rs34204969; rs35400739; rs13053402; rs9622193; rs17883936; rs34918147; rs34345283; rs17879027; rs9619539; rs9622191; rs10628026; rs12628401; rs17884230; rs34867836; rs13054865; rs13058638; rs17880184; rs5750104; rs36054326; rs35427263; rs9610290; rs3074372; rs35622428; rs9619534; rs35071398; rs5999811; rs5999813; rs5999810; rs9619537; rs9619535; rs34824930; rs13057211; rs5999812; rs17879594; rs12159977; rs1078979; rs12168789; rs12170872; rs2307334; rs2307335; rs2307337; rs3761438; rs4603883; rs4645726; rs4645729; rs4645731; rs4645741; rs4645742; rs4645746; rs4645747; rs5755722; rs5995096; rs5999817; rs5999819; rs713618; rs713688; rs713873; rs735266; rs735267; rs737777; rs743811; rs743813; rs743815; rs9306299; rs9619540

# Macromolecular_Interacting_Partner_4_General_References:
3345742; 10591208; 2911585; 2537723; 10467099

# Macromolecular_Interacting_Partner_4_References:
15751016; 15803024; 16129699; 16181103

# Macromolecular_Interacting_Partner_5_ID:
7605

# Macromolecular_Interacting_Partner_5_Name:
Tissue factor precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
TF; Coagulation factor III; Thromboplastin; CD142 antigen

# Macromolecular_Interacting_Partner_5_Gene_Name:
F3

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Tissue factor precursor
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
295

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
33068

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
7.09

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  organismal physiological process
Process:  regulation of body fluids
Process:  hemostasis
Process:  blood coagulation
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF01108:Tissue_fac

# Macromolecular_Interacting_Partner_5_Signals:
1-32

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
252-274

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
339504

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
TF_HUMAN (P13726)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
F3

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
F3

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:3541

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>888 bp
ATGGAGACCCCTGCCTGGCCCCGGGTCCCGCGCCCCGAGACCGCCGTCGCTCGGACGCTC
CTGCTCGGCTGGGTCTTCGCCCAGGTGGCCGGCGCTTCAGGCACTACAAATACTGTGGCA
GCATATAATTTAACTTGGAAATCAACTAATTTCAAGACAATTTTGGAGTGGGAACCCAAA
CCCGTCAATCAAGTCTACACTGTTCAAATAAGCACTAAGTCAGGAGATTGGAAAAGCAAA
TGCTTTTACACAACAGACACAGAGTGTGACCTCACCGACGAGATTGTGAAGGATGTGAAG
CAGACGTACTTGGCACGGGTCTTCTCCTACCCGGCAGGGAATGTGGAGAGCACCGGTTCT
GCTGGGGAGCCTCTGTATGAGAACTCCCCAGAGTTCACACCTTACCTGGAGACAAACCTC
GGACAGCCAACAATTCAGAGTTTTGAACAGGTGGGAACAAAAGTGAATGTGACCGTAGAA
GATGAACGGACTTTAGTCAGAAGGAACAACACTTTCCTAAGCCTCCGGGATGTTTTTGGC
AAGGACTTAATTTATACACTTTATTATTGGAAATCTTCAAGTTCAGGAAAGAAAACAGCC
AAAACAAACACTAATGAGTTTTTGATTGATGTGGATAAAGGAGAAAACTACTGTTTCAGT
GTTCAAGCAGTGATTCCCTCCCGAACAGTTAACCGGAAGAGTACAGACAGCCCGGTAGAG
TGTATGGGCCAGGAGAAAGGGGAATTCAGAGAAATATTCTACATCATTGGAGCTGTGGCA
TTTGTGGTCATCATCCTTGTCATCATCCTGGCTATATCTCTACACAAGTGTAGAAAGGCA
GGAGTGGGGCAGAGCTGGAAGGAGAACTCCCCACTGAATGTTTCATAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
M16553

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_5_Locus:
1p22-p21

# Macromolecular_Interacting_Partner_5_SNPs:
rs5901; rs3917604; rs3789683; rs698946; rs3354; rs841691; rs3917632; rs3917633; rs841692; rs3917634; rs762485; rs1144301; rs841696; rs1146516; rs762484; rs2021962; rs3917611; rs725299; rs696619; rs1144302; rs610277; rs841695; rs3748017; rs725298; rs3748016; rs3917605; rs3917643; rs841697; rs3917606; rs2021963; rs2794470; rs1144300; rs1324214; rs592435; rs13306321; rs2391424; rs3917615; rs3917630; rs3917610; rs3917631; rs41346844; rs1034363; rs841693; rs3748015; rs3789685; rs3917620; rs3917628; rs5776224; rs3761955; rs958587; rs1361600; rs698948; rs3917637; rs3761953; rs3917627; rs28672143; rs13306322; rs41439746; rs1048528; rs11554414; rs3917635; rs34972976; rs3917603; rs3917621; rs3917616; rs3917626; rs3917608; rs337595; rs13306323; rs10537005; rs3917617; rs3917614; rs3917609; rs3917618; rs12047777; rs2794471; rs2762507; rs3917644; rs41457649; rs41439849; rs3917613; rs35889484; rs3917619; rs841694; rs2022061; rs3917607; rs3917625; rs337594; rs3917612; rs3917641; rs698947; rs3917636; rs10699909; rs10658583; rs3917638; rs958292; rs337593; rs34699197; rs3917642; rs1028736; rs587552; rs630382; rs644530; rs6692345; rs6700456; rs698942; rs698943; rs698944; rs7555399

# Macromolecular_Interacting_Partner_5_General_References:
2823875; 3297348; 3037536; 3424286; 2719931; 3166978; 8086403; 8609606; 8598903; 9925787

# Macromolecular_Interacting_Partner_5_References:
15812113; 15924639; 16504712; 17097984

# Macromolecular_Interacting_Partner_6_ID:
6988

# Macromolecular_Interacting_Partner_6_Name:
Canalicular multispecific organic anion transporter 1

# Macromolecular_Interacting_Partner_6_Synonyms:
ATP-binding cassette sub-family C member 2; Multidrug resistance-associated protein 2; Canalicular multidrug resistance protein

# Macromolecular_Interacting_Partner_6_Gene_Name:
ABCC2

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Canalicular multispecific organic anion transporter 1
MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSS
TTKLYLAKQVFVGFLLILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLVLLIQYS
RQWCVQKNSWFLSLFWILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILI
FSAFSENNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVS
KFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSG
TKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIG
YLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGET
VNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAIL
STKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFS
QLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMI
SSMLQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLD
IMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNIL
FGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLD
IYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIV
EKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAAS
ITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETG
KVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQR
DMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRI
VNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMF
YVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSW
ITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTS
EIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGI
TCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTII
PQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIG
QRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMD
SDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIENVNSTKF

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
1545

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
174194

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
8.46

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  transporter activity
Function:  ATPase activity
Function:  hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Function:  ATPase activity, coupled to transmembrane movement of substances
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_6_Specific_Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00664:ABC_membrane;
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
28-48
69-89
94-114
127-147
166-186
314-334
361-381
438-458
462-482
545-565
588-608
972-992
1034-1054
1098-1118
1120-1140
1212-1232
1235-1255

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
1764162

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
MRP2_HUMAN (Q92887)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
ABCC2

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
ABCC2

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:53

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>4638 bp
ATGCTGGAGAAGTTCTGCAACTCTACTTTTTGGAATTCCTCATTCCTGGACAGTCCGGAG
GCAGACCTGCCACTTTGTTTTGAGCAAACTGTTCTGGTGTGGATTCCCTTGGGCTTCCTA
TGGCTCCTGGCCCCCTGGCAGCTTCTCCACGTGTATAAATCCAGGACCAAGAGATCCTCT
ACCACCAAACTCTATCTTGCTAAGCAGGTATTCGTTGGTTTTCTTCTTATTCTAGCAGCC
ATAGAGCTGGCCCTTGTACTCACAGAAGACTCTGGACAAGCCACAGTCCCTGCTGTTCGA
TATACCAATCCAAGCCTCTACCTAGGCACATGGCTCCTGGTTTTGCTGATCCAATACAGC
AGACAATGGTGTGTACAGAAAAACTCCTGGTTCCTGTCCCTATTCTGGATTCTCTCGATA
CTCTGTGGCACTTTCCAATTTCAGACTCTGATCCGGACACTCTTACAGGGTGACAATTCT
AATCTAGCCTACTCCTGCCTGTTCTTCATCTCCTACGGATTCCAGATCCTGATCCTGATC
TTTTCAGCATTTTCAGAAAATAATGAGTCATCAAATAATCCATCATCCATAGCTTCATTC
CTGAGTAGCATTACCTACAGCTGGTATGACAGCATCATTCTGAAAGGCTACAAGCGTCCT
CTGACACTCGAGGATGTCTGGGAAGTTGATGAAGAGATGAAAACCAAGACATTAGTGAGC
AAGTTTGAAACGCACATGAAGAGAGAGCTGCAGAAAGCCAGGCGGGCACTCCAGAGACGG
CAGGAGAAGAGCTCCCAGCAGAACTCTGGAGCCAGGCTGCCTGGCTTGAACAAGAATCAG
AGTCAAAGCCAAGATGCCCTTGTCCTGGAAGATGTTGAAAAGAAAAAAAAGAAGTCTGGG
ACCAAAAAAGATGTTCCAAAATCCTGGTTGATGAAGGCTCTGTTCAAAACTTTCTACATG
GTGCTCCTGAAATCATTCCTACTGAAGCTAGTGAATGACATCTTCACGTTTGTGAGTCCT
CAGCTGCTGAAATTGCTGATCTCCTTTGCAAGTGACCGTGACACATATTTGTGGATTGGA
TATCTCTGTGCAATCCTCTTATTCACTGCGGCTCTCATTCAGTCTTTCTGCCTTCAGTGT
TATTTCCAACTGTGCTTCAAGCTGGGTGTAAAAGTACGGACAGCTATCATGGCTTCTGTA
TATAAGAAGGCATTGACCCTATCCAACTTGGCCAGGAAGGAGTACACCGTTGGAGAAACA
GTGAACCTGATGTCTGTGGATGCCCAGAAGCTCATGGATGTGACCAACTTCATGCACATG
CTGTGGTCAAGTGTTCTACAGATTGTCTTATCTATCTTCTTCCTATGGAGAGAGTTGGGA
CCCTCAGTCTTAGCAGGTGTTGGGGTGATGGTGCTTGTAATCCCAATTAATGCGATACTG
TCCACCAAGAGTAAGACCATTCAGGTCAAAAATATGAAGAATAAAGACAAACGTTTAAAG
ATCATGAATGAGATTCTTAGTGGAATCAAGATCCTGAAATATTTTGCCTGGGAACCTTCA
TTCAGAGACCAAGTACAAAACCTCCGGAAGAAAGAGCTCAAGAACCTGCTGGCCTTTAGT
CAACTACAGTGTGTAGTAATATTCGTCTTCCAGTTAACTCCAGTCCTGGTATCTGTGGTC
ACATTTTCTGTTTATGTCCTGGTGGATAGCAACAATATTTTGGATGCACAAAAGGCCTTC
ACCTCCATTACCCTCTTCAATATCCTGCGCTTTCCCCTGAGCATGCTTCCCATGATGATC
TCCTCCATGCTCCAGGCCAGTGTTTCCACAGAGCGGCTAGAGAAGTACTTGGGAGGGGAT
GACTTGGACACATCTGCCATTCGACATGACTGCAATTTTGACAAAGCCATGCAGTTTTCT
GAGGCCTCCTTTACCTGGGAACATGATTCGGAAGCCACAGTCCGAGATGTGAACCTGGAC
ATTATGGCAGGCCAACTTGTGGCTGTGATAGGCCCTGTCGGCTCTGGGAAATCCTCCTTG
ATATCAGCCATGCTGGGAGAAATGGAAAATGTCCACGGGCACATCACCATCAAGGGCACC
ACTGCCTATGTCCCACAGCAGTCCTGGATTCAGAATGGCACCATAAAGGACAACATCCTT
TTTGGAACAGAGTTTAATGAAAAGAGGTACCAGCAAGTACTGGAGGCCTGTGCTCTCCTC
CCAGACTTGGAAATGCTGCCTGGAGGAGATTTGGCTGAGATTGGAGAGAAGGGTATAAAT
CTTAGTGGGGGTCAGAAGCAGCGGATCAGCCTGGCCAGAGCTACCTACCAAAATTTAGAC
ATCTATCTTCTAGATGACCCCCTGTCTGCAGTGGATGCTCATGTAGGAAAACATATTTTT
AATAAGGTCTTGGGCCCCAATGGCCTGTTGAAAGGCAAGACTCGACTCTTGGTTACACAT
AGCATGCACTTTCTTCCTCAAGTGGATGAGATTGTAGTTCTGGGGAATGGAACAATTGTA
GAGAAAGGATCCTACAGTGCTCTCCTGGCCAAAAAAGGAGAGTTTGCTAAGAATCTGAAG
ACATTTCTAAGACATACAGGCCCTGAAGAGGAAGCCACAGTCCATGATGGCAGTGAAGAA
GAAGACGATGACTATGGGCTGATATCCAGTGTGGAAGAGATCCCCGAAGATGCAGCCTCC
ATAACCATGAGAAGAGAGAACAGCTTTCGTCGAACACTTAGCCGCAGTTCTAGGTCCAAT
GGCAGGCATCTGAAGTCCCTGAGAAACTCCTTGAAAACTCGGAATGTGAATAGCCTGAAG
GAAGACGAAGAACTAGTGAAAGGACAAAAACTAATTAAGAAGGAATTCATAGAAACTGGA
AAGGTGAAGTTCTCCATCTACCTGGAGTACCTACAAGCAATAGGATTGTTTTCGATATTC
TTCATCATCCTTGCGTTTGTGATGAATTCTGTGGCTTTTATTGGATCCAACCTCTGGCTC
AGTGCTTGGACCAGTGACTCTAAAATCTTCAATAGCACCGACTATCCAGCATCTCAGAGG
GACATGAGAGTTGGAGTCTACGGAGCTCTGGGATTAGCCCAAGGTATATTTGTGTTCATA
GCACATTTCTGGAGTGCCTTTGGTTTCGTCCATGCATCAAATATCTTGCACAAGCAACTG
CTGAACAATATCCTTCGAGCACCTATGAGATTTTTTGACACAACACCCACAGGCCGGATT
GTGAACAGGTTTGCCGGCGATATTTCCACAGTGGATGACACCCTGCCTCAGTCCTTGCGC
AGCTGGATTACATGCTTCCTGGGGATAATCAGCACCCTTGTCATGATCTGCATGGCCACT
CCTGTCTTCACCATCATCGTCATTCCTCTTGGCATTATTTATGTATCTGTTCAGATGTTT
TATGTGTCTACCTCCCGCCAGCTGAGGCGTCTGGACTCTGTCACCAGGTCCCCAATCTAC
TCTCACTTCAGCGAGACCGTATCAGGTTTGCCAGTTATCCGTGCCTTTGAGCACCAGCAG
CGATTTCTGAAACACAATGAGGTGAGGATTGACACCAACCAGAAATGTGTCTTTTCCTGG
ATCACCTCCAACAGGTGGCTTGCAATTCGCCTGGAGCTGGTTGGGAACCTGACTGTCTTC
TTTTCAGCCTTGATGATGGTTATTTATAGAGATACCCTAAGTGGGGACACTGTTGGCTTT
GTTCTGTCCAATGCACTCAATATCACACAAACCCTGAACTGGCTGGTGAGGATGACATCA
GAAATAGAGACCAACATTGTGGCTGTTGAGCGAATAACTGAGTACACAAAAGTGGAAAAT
GAGGCACCCTGGGTGACTGATAAGAGGCCTCCGCCAGATTGGCCCAGCAAAGGCAAGATC
CAGTTTAACAACTACCAAGTGCGGTACCGACCTGAGCTGGATCTGGTCCTCAGAGGGATC
ACTTGTGACATCGGTAGCATGGAGAAGATTGGTGTGGTGGGCAGGACAGGAGCTGGAAAG
TCATCCCTCACAAACTGCCTCTTCAGAATCTTAGAGGCTGCCGGTGGTCAGATTATCATT
GATGGAGTAGATATTGCTTCCATTGGGCTCCACGACCTCCGAGAGAAGCTGACCATCATC
CCCCAGGACCCCATCCTGTTCTCTGGAAGCCTGAGGATGAATCTCGACCCTTTCAACAAC
TACTCAGATGAGGAGATTTGGAAGGCCTTGGAGCTGGCTCACCTCAAGTCTTTTGTGGCC
AGCCTGCAACTTGGGTTATCCCACGAAGTGACAGAGGCTGGTGGCAACCTGAGCATAGGC
CAGAGGCAGCTGCTGTGCCTGGGCAGGGCTCTGCTTCGGAAATCCAAGATCCTGGTCCTG
GATGAGGCCACTGCTGCGGTGGATCTAGAGACAGACAACCTCATTCAGACGACCATCCAA
AACGAGTTCGCCCACTGCACAGTGATCACCATCGCCCACAGGCTGCACACCATCATGGAC
AGTGACAAGGTAATGGTCCTAGACAACGGGAAGATTATAGAGTGCGGCAGCCCTGAAGAA
CTGCTACAAATCCCTGGACCCTTTTACTTTATGGCTAAGGAAGCTGGCATTGAGAATGTG
AACAGCACAAAATTCTAG

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
U63970

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_6_Locus:
10q24

# Macromolecular_Interacting_Partner_6_SNPs:
rs2273697; rs927344; rs7080681; rs8187699; rs8187692; rs17216317; rs17222723; rs8187710; rs17222674; rs17222547; rs8187706; rs3740070; rs8187709; rs8187707; rs3740066; rs17216198; rs7899457; rs17216296; rs1137968; rs4267009; rs34937870; rs717620; rs17216156; rs2002042; rs2804400; rs2756109; rs2073337; rs2756114; rs8187674; rs3740065; rs2756104; rs4148396; rs4148397; rs7393105; rs3740063; rs6584327; rs3740073; rs4148398; rs2756106; rs2756112; rs7476245; rs3740064; rs3740074; rs17112266; rs4581377; rs2756103; rs9794323; rs11818057; rs3758395; rs7914602; rs4148399; rs2073336; rs2756113; rs4148391; rs11597282; rs10786571; rs4148384; rs4077146; rs4148394; rs2756105; rs2804398; rs2224506; rs3740067; rs11595888; rs35885490; rs2756108; rs7901377; rs10883416; rs4919395; rs3780882; rs7920591; rs9794324; rs2902299; rs34839727; rs10082440; rs3780880; rs4611137; rs3740069; rs35408364; rs7393085; rs7900740; rs12257125; rs10748792; rs7090621; rs34456559; rs7922379; rs9633711; rs4148395; rs34660705; rs11190291; rs11816875; rs10883417; rs2756111; rs2804399; rs34683029; rs7898096; rs7906080; rs35509621; rs3740068; rs9943464; rs12257158; rs10883413; rs11498758; rs10786572; rs2804397; rs7922376; rs10748791; rs1962102; rs9804274; rs4362077; rs2756110; rs10883414; rs9794322; rs9633710; rs7076773; rs7920448; rs1885301; rs7910642; rs2804402; rs12251995; rs3740071; rs3740072; rs41318029; rs4148400; rs41286890; rs4148401; rs11362742; rs35648207; rs12268545; rs35371064; rs11498759; rs12771624; rs28697226; rs11190289; rs10450371; rs35688626; rs2862689; rs35000277; rs35762771; rs33925378; rs35125216; rs4994144; rs3824610; rs10667377; rs12252945; rs35530113; rs34849284; rs35428269; rs34871071; rs4148392; rs34542394; rs10579032; rs34992254; rs3893194; rs9731882; rs10561194; rs35963473; rs33998610; rs34709093; rs2281637; rs35827068; rs11190286; rs9733831; rs3047481; rs34662003; rs35138969; rs34959207; rs9733799; rs9420768; rs4148393; rs10577917; rs9731254; rs35683214; rs11817399; rs4412694; rs34351781; rs36233263; rs41318033; rs1136912; rs12253584; rs35296652; rs10883415; rs34967745; rs7900969; rs11598792; rs7078268; rs41286888; rs3893193; rs11498760; rs35883614; rs4439452; rs41318031; rs28434545; rs4427497; rs35152927; rs7922864; rs33947178; rs10644836; rs28498571; rs10453988; rs34093243; rs33948136; rs34256643; rs11190288; rs9731258; rs3047477; rs11190290; rs11190294; rs11594329; rs36042666; rs35852420; rs3961715; rs4148383; rs34382900; rs35836893; rs3780881; rs28409805; rs35388339; rs10683821; rs7394179; rs34343354; rs34401027; rs9731264; rs35091989; rs12240781; rs3047479; rs10082536; rs5787360; rs35682621; rs5787361; rs4148402; rs34743267; rs12258415; rs34937591; rs28537453; rs34918146; rs5013873; rs28532665; rs11190287; rs12359960; rs7901067; rs10555122; rs11442349; rs35567746; rs41318025; rs36012424; rs35853830; rs10559742; rs4919397; rs34706355; rs7899330; rs12253129; rs41318027; rs34398741; rs35444155; rs41318023; rs11592017; rs2490765; rs34423076; rs34009725; rs34827047; rs34834811; rs35066717; rs3047475; rs34693955; rs34200720; rs35059917; rs11190295; rs11190297; rs11190298; rs1137675; rs11816708; rs12268782; rs12762549; rs12826; rs17216149; rs17216177; rs17216212; rs17216345; rs17222540; rs17222554; rs17222561; rs17222589; rs17222596; rs17222610; rs17222624; rs17222632; rs17222744; rs17580483; rs2145852; rs2145853; rs2180989; rs2180990; rs2249983; rs2756098; rs2756107; rs4148385; rs4148386; rs4148387; rs4148388; rs4148389; rs7067971; rs7068581; rs7476419; rs7898268; rs7899883; rs7903716

# Macromolecular_Interacting_Partner_6_General_References:
8797578; 8662992; 10464142; 11076395; 11500505; 9425227; 10053008; 11093739; 11477083; 11266082

# Macromolecular_Interacting_Partner_6_References:
15846474; 15901347; 16080518; 16083704

# Macromolecular_Interacting_Partner_7_ID:
8170

# Macromolecular_Interacting_Partner_7_Name:
Vascular cell adhesion protein 1 precursor

# Macromolecular_Interacting_Partner_7_Synonyms:
V-CAM 1; CD106 antigen; INCAM-100

# Macromolecular_Interacting_Partner_7_Gene_Name:
VCAM1

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Vascular cell adhesion protein 1 precursor
MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR
TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE
IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV
TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG
SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN
RKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVR
SEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSS
VTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKA
LVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFP
APKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP
KDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQL
KDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFA
RKANMKGSYSLVEAQKSKV

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
739

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
81277

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
4.87

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular process
Process:  cell adhesion
Process:  cell-cell adhesion
 ||
>>>
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF05790:C2-set;
PF07679:I-set;
PF00047:ig;
PF07686:V-set

# Macromolecular_Interacting_Partner_7_Signals:
1-24

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
699-720

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
179886

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
VCAM1_HUMAN (P19320)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
VCAM1

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
VCAM1

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:12663

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1944 bp
ATGCCTGGGAAGATGGTCGTGATCCTTGGAGCCTCAAATATACTTTGGATAATGTTTGCA
GCTTCTCAAGCTTTTAAAATCGAGACCACCCCAGAATCTAGATATCTTGCTCAGATTGGT
GACTCCGTCTCATTGACTTGCAGCACCACAGGCTGTGAGTCCCCATTTTTCTCTTGGAGA
ACCCAGATAGATAGTCCACTGAATGGGAAGGTGACGAATGAGGGGACCACATCTACGCTG
ACAATGAATCCTGTTAGTTTTGGGAACGAACACTCTTACCTGTGCACAGCAACTTGTGAA
TCTAGGAAATTGGAAAAAGGAATCCAGGTGGAGATCTACTCTTTTCCTAAGGATCCAGAG
ATTCATTTGAGTGGCCCTCTGGAGGCTGGGAAGCCGATCACAGTCAAGTGTTCAGTTGCT
GATGTATACCCATTTGACAGGCTGGAGATAGACTTACTGAAAGGAGATCATCTCATGAAG
AGTCAGGAATTTCTGGAGGATGCAGACAGGAAGTCCCTGGAAACCAAGAGTTTGGAAGTA
ACCTTTACTCCTGTCATTGAGGATATTGGAAAAGTTCTTGTTTGCCGAGCTAAATTACAC
ATTGATGAAATGGATTCTGTGCCCACAGTAAGGCAGGCTGTAAAAGAATTGCAAGTCTAC
ATATCACCCAAGAATACAGTTATTTCTGTGAATCCATCCACAAAGCTGCAAGAAGGTGGC
TCTGTGACCATGACCTGTTCCAGCGAGGGTCTACCAGCTCCAGAGATTTTCTGGAGTAAG
AAATTAGATAATGGGAATCTACAGCACCTTTCTGGAAATGCAACTCTCACCTTAATTGCT
ATGAGGATGGAAGATTCTGGAATTTATGTGTGTGAAGGAGTTAATTTGATTGGGAAAAAC
AGAAAAGAGGTGGAATTAATTGTTCAAGCATTCCCTAGAGATCCAGAAATCGAGATGAGT
GGTGGCCTCGTGAATGGGAGCTCTGTCACTGTAAGCTGCAAGGTTCCTAGCGTGTACCCC
CTTGACCGGCTGGAGATTGAATTACTTAAGGGGGAGACTATTCTGGAGAATATAGAGTTT
TTGGAGGATACGGATATGAAATCTCTAGAGAACAAAAGTTTGGAAATGACCTTCATCCCT
ACCATTGAAGATACTGGAAAAGCTCTTGTTTGTCAGGCTAAGTTACATATTGATGACATG
GAATTCGAACCCAAACAAAGGCAGAGTACGCAAACACTTTATGTCAATGTTGCCCCCAGA
GATACAACCGTCTTGGTCAGCCCTTCCTCCATCCTGGAGGAAGGCAGTTCTGTGAATATG
ACATGCTTGAGCCAGGGCTTTCCTGCTCCGAAAATCCTGTGGAGCAGGCAGCTCCCTAAC
GGGGAGCTACAGCCTCTTTCTGAGAATGCAACTCTCACCTTAATTTCTACAAAAATGGAA
GATTCTGGGGTTTATTTATGTGAAGGAATTAACCAGGCTGGAAGAAGCAGAAAGGAAGTG
GAATTAATTATCCAAGTTACTCCAAAAGACATAAAACTTACAGCTTTTCCTTCTGAGAGT
GTCAAAGAAGGAGACACTGTCATCATCTCTTGTACATGTGGAAATGTTCCAGAAACATGG
ATAATCCTGAAGAAAAAAGCGGAGACAGGAGACACAGTACTAAAATCTATAGATGGCGCC
TATACCATCCGAAAGGCCCAGTTGAAGGATGCGGGAGTATATGAATGTGAATCTAAAAAC
AAAGTTGGCTCACAATTAAGAAGTTTAACACTTGATGTTCAAGGAAGAGAAAACAACAAA
GACTATTTTTCTCCTGAGCTTCTCGTGCTCTATTTTGCATCCTCCTTAATAATACCTGCC
ATTGGAATGATAATTTACTTTGCAAGAAAAGCCAACATGAAGGGGTCATATAGTCTTGTA
GAAGCACAGAAATCAAAAGTGTAG

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
M30257

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_7_Locus:
1p32-p31

# Macromolecular_Interacting_Partner_7_SNPs:
rs3783613; rs3783612; rs3783611; rs3783615; rs34100871; rs34228330; rs34199378; rs3176879; rs3176878; rs3783621; rs3783618; rs3783617; rs3783608; rs3783609; rs3783619; rs3783610; rs3783607; rs3176875; rs3176860; rs3176874; rs3176876; rs3917012; rs2392221; rs3181088; rs3765685; rs3819950; rs3917041; rs3176870; rs3917040; rs3176861; rs3917037; rs2209627; rs3176862; rs3917067; rs3176869; rs3917016; rs3917043; rs3917038; rs3917075; rs3917033; rs3917058; rs3917034; rs3917019; rs3917020; rs3917064; rs3917042; rs3176871; rs3176863; rs3917059; rs3917018; rs1476408; rs3176877; rs3917009; rs3917062; rs3176867; rs3917036; rs3181091; rs3917053; rs3181089; rs3917032; rs3917028; rs3917070; rs3917056; rs3917060; rs3917047; rs3917072; rs3917057; rs3917011; rs3917065; rs3917074; rs34186667; rs3917051; rs3176864; rs3917068; rs3917015; rs3917049; rs3917073; rs3917052; rs3917010; rs3176859; rs3917069; rs3917071; rs3917066; rs3917014; rs3176868; rs3917055; rs3917031; rs3917063; rs34599539; rs3917008; rs1041163; rs3181092; rs1409419; rs3917024; rs3181093; rs3170794; rs3181087; rs3783598; rs3783624; rs3783595; rs3783605; rs3917022; rs3917025; rs3783601; rs3783597; rs3917027; rs3917026; rs3783599; rs3783603; rs34708918; rs17123276; rs34682069; rs41287272; rs41402047; rs3194002; rs3783620; rs12740248; rs3917048; rs34736359; rs35831577; rs36046590; rs35811606; rs34871919; rs34681548; rs10680526; rs34203893; rs3917013; rs34484900; rs35625117; rs3176872; rs35904710; rs35377403; rs35668724; rs3917050; rs3917061; rs36115922; rs34602730; rs3917046; rs35885801; rs34934334; rs3917039; rs3917045; rs3181090; rs34552536; rs3917054; rs3917035; rs3917030; rs3176865; rs35026515; rs35742683; rs34768146; rs3917044; rs3917017; rs34577442; rs34037455; rs3917029; rs3783606; rs3783600; rs3917021; rs35200787; rs17109912; rs11420952; rs1800821; rs11302130; rs3834000; rs34900848; rs10493936; rs12080503; rs12129732; rs12240047; rs12403247; rs12409568; rs12732056; rs12747073; rs1571049; rs1582090; rs1582091; rs2050471; rs2094241; rs2209628; rs34853105; rs35964031; rs35978793; rs3917078; rs4520436; rs4584412; rs6660837; rs6680254

# Macromolecular_Interacting_Partner_7_General_References:
2688898; 1699207; 1707873; 1715583; 1379595; 1707234; 1377228; 7531291; 7539925

# Macromolecular_Interacting_Partner_7_References:
15749910

End of HMDB00054

Beginning of HMDB00055
# Accession_No:
HMDB00055

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-05-23 11:12:38

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Cellobiose

# Description:
A disaccharide consisting of two glucose units in beta (1-4) glycosidic linkage. Obtained from the partial hydrolysis of cellulose, is commonly used as an indicator carbohydrate for intestinal permeability in Crohn's syndrome and malabsorption syndrome.  This carbohydrate is exogenous.  It is not produced by the body nor is it metabolized by the body, but may be found in some food products (vegetables, fruits, corn syrups, etc.).  Cellobiose is also an indispensable part of fabric especially cotton, jute, and other cellulosic material.

# Synonyms:
4-(b-D-Glucosido)-D-glucose; 4-(beta-D-Glucosido)-D-glucose; 4-Beta-D-Glucopyranosyl-D-glucopyranose; 4-O-b-D-Glucopyranosyl-D-glucose; 4-O-beta-D-Glucopyranosyl-D-glucose; Cellobiose; Cellose; D-(+)-Cellobiose; D-Cellobiose; D-Glucosyl-b-(1->4)-D-glucose; D-Glucosyl-beta-(1-4)-D-glucose; 4-(b-delta-Glucosido)-delta-glucose; 4-(beta-delta-Glucosido)-delta-glucose; 4-Beta-delta-Glucopyranosyl-delta-glucopyranose; 4-O-beta-delta-Glucopyranosyl-delta-glucose; delta-(+)-Cellobiose; delta-Cellobiose; delta-Glucosyl-beta-(1->4)-delta-glucose; delta-Glucosyl-beta-(1-4)-delta-glucose; D-Glucosyl-beta-(1->4)-D-glucose

# Chemical_IUPAC_Name:
6-(hydroxymethyl)-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-oxane-2,3,4-triol

# Chemical_Formula:
C12H22O11

# Chemical_Structure:
tbl_chemical:::HMDB00055_ZOOM.png:::119283161159880103

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00055_THUMB.png:::119283160956814287

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Sugars; Disaccharides

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiacetal; acetal; primary alcohol; secondary alcohol; 1,2-diol; heterocyclic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
342.11621

# Molecular_Weight_Avg:
342.29651

# Smiles_String_isomeric:
OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

# Smiles_String_canonical:
OCC1OC(OC2C(CO)OC(O)C(O)C2O)C(O)C(O)C1O

# KEGG_Compound_ID:
C00185

# BioCyc_ID:
CPD-1161

# PubChem_CID:
439178

# PubChem_SID:
3485; 10298232

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Cellobiose

# METLIN_ID:
3480

# Ref_ID:
9742462; 15561487; 16150825; 3924445; 15546811; 15980615; 15774668; 1476702; 241430; 10828724; 15881656; 15538836; 2497056

# ChEBI_ID:
17057

# CAS_Registry_Number:
528-50-7

# InChI:
InChI=1/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5-,6+,7-,8-,9-,10-,11-,12+/m1/s1

# Synthesis_Reference:
 Journal of the Indian Chemical Society  (1985),  62(8),  595-9

# Melting_Point:
Not Available

# Melting_Point_predicted:
140.9 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
111.0 mg/mL at 15 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
586.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-3.00 [Predicted by ALOGPS]; -4.3 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Cellobiose.mol:::1132723804000455879

# SDF_File_[Text]:
tbl_chemical:::HMDB00055.sdf:::119283160459191632

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00055.pdb:::11928316076673323

# PDB_ID:
1G0C

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1G0C.txt:::1132720900437696097

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::050121_P00_10_IS_1DP_presat_expanded_1.gif:::11416822039063890

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::050121_P00_10_IS_1DP_presat.zip:::1175124307425405870

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050121_P00_10_IS_1DP_Assigned.png:::116553216468177634

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050121_P00_10_IS_2DHSQC_1099.png:::114806902199085037

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050121_P00_10_IS_2DHSQC_1099.zip:::11480690219961951

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050121_P00_10_IS_2DHSQC_1099_Assigned.png:::116223096145086402

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Cellobiose.gif:::1132732103484600866

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00055_peaks.txt:::1156309515274690204

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Cellobiose_C.gif:::1132737669525744543

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00055_peaks.txt:::115631070574654044

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00055L.png:::117555263014224767; Medium Energy:tbl_ms:::HMDB00055M.png:::117555268403839696; High Energy:tbl_ms:::HMDB00055H.png:::117555271691941095

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000138.png:::116907444148457774

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000138.txt:::116907444148425493

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000138.png:::116890828520363410

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000138.txt:::11689082856099668

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Intestine; Spleen

# deuterated:
No

# Biofluid_Location:
Not Available

# Concentration_[Normal]:
Not Available


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Carotenemia; Coeliac Disease; Nephrosis

# Pathway_Names:
Glycosphingolipid metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00600

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5517

# Metabolic_Enzyme_1_Name:
Eosinophil peroxidase precursor

# Metabolic_Enzyme_1_Synonyms:
EPO[Contains: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain]

# Metabolic_Enzyme_1_Gene_Name:
EPX

# Metabolic_Enzyme_1_Protein_Sequence:
>Eosinophil peroxidase precursor
MHLLPALAGVLATLVLAQPCEGTDPASPGAVETSVLRDCIAEAKLLVDAAYNWTQKSIKQ
RLRSGSASPMDLLSYFKQPVAATRTVVRAADYMHVALGLLEEKLQPQRSGPFNVTDVLTE
PQLRLLSQASGCALRDQAERCSDKYRTITGRCNNKRRPLLGASNQALARWLPAEYEDGLS
LPFGWTPSRRRNGFLLPLVRAVSNQIVRFPNERLTSDRGRALMFMQWGQFIDHDLDFSPE
SPARVAFTAGVDCERTCAQLPPCFPIKIPPNDPRIKNQRDCIPFFRSAPSCPQNKNRVRN
QINALTSFVDASMVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGRALLPFDNLHDDPCL
LTNRSARIPCFLAGDTRSTETPKLAAMHTLFMREHNRLATELRRLNPRWNGDKLYNEARK
IMGAMVQIITYRDFLPLVLGKARARRTLGHYRGYCSNVDPRVANVFTLAFRFGHTMLQPF
MFRLDSQYRASAPNSHVPLSSAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDEL
RDRLFRQVRRIGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLAR
KFLNLYGTPDNIDIWIGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWWQKRGVFTK
RQRKALSRISLSRIICDNTGITTVSRDIFRANIYPRGFVNCSRIPRLNLSAWRGT

# Metabolic_Enzyme_1_Number_of_Residues:
715

# Metabolic_Enzyme_1_Molecular_Weight:
81042

# Metabolic_Enzyme_1_Theoretical_pI:
10.81

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Donor + H(2)O(2) = oxidized donor + 2 H(2)O

# Metabolic_Enzyme_1_Pathway:
map00360  Phenylalanine metabolism;
 map00590  Prostaglandin and leukotriene metabolism;
 map00680  Methane metabolism;
 map00940  Stilbene, coumarine and lignin biosynthesis

# Metabolic_Enzyme_1_Reaction:
donor + H2O2 = oxidized donor + 2 H2O

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF03098:An_peroxidase

# Metabolic_Enzyme_1_Signals:
1-17

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.11.1.7

# Metabolic_Enzyme_1_GenBank_ID_Protein:
182146

# Metabolic_Enzyme_1_SwissProt_ID:
PERE_HUMAN (P11678)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
EPX

# Metabolic_Enzyme_1_Geneatlas_id:
EPX

# Metabolic_Enzyme_1_hgnc_id:
HGNC:3423

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils

# Metabolic_Enzyme_1_Gene_Sequence:
>2148 bp
ATGCATCTGCTCCCAGCCCTGGCAGGGGTCCTGGCCACACTCGTCCTCGCCCAGCCCTGT
GAGGGCACTGACCCAGCCTCCCCTGGGGCAGTGGAGACCTCGGTCCTGCGAGACTGCATA
GCAGAGGCCAAGTTGCTGGTGGATGCTGCCTACAATTGGACCCAGAAGAGCATCAAGCAG
CGGCTTCGCAGCGGTTCAGCCAGCCCCATGGACCTCCTGTCCTACTTCAAACAACCGGTA
GCAGCCACCAGGACAGTTGTTCGGGCCGCAGATTATATGCATGTGGCTTTGGGGCTGCTT
GAAGAGAAGTTACAACCCCAGCGGTCCGGACCCTTCAATGTCACTGATGTGCTAACAGAA
CCACAGCTGCGGCTGCTGTCCCAGGCCAGTGGCTGTGCTCTCCGGGACCAGGCCGAGCGC
TGCAGCGACAAGTACCGCACCATCACTGGACGGTGCAACAACAAGAGGAGACCCTTGCTA
GGGGCCTCCAACCAGGCTCTGGCTCGCTGGCTGCCCGCCGAGTATGAGGATGGGCTGTCG
CTCCCCTTCGGCTGGACCCCCAGCAGGAGGCGCAATGGCTTCCTTCTCCCTCTTGTCCGG
GCTGTCTCCAACCAGATTGTGCGCTTCCCCAATGAGAGACTGACCTCCGACCGTGGCCGA
GCCCTCATGTTCATGCAGTGGGGCCAGTTCATTGACCATGACCTGGACTTCTCCCCGGAG
TCCCCGGCCAGAGTGGCCTTCACTGCAGGCGTTGACTGTGAGAGGACCTGCGCCCAGCTG
CCCCCCTGCTTTCCCATCAAGATCCCACCCAATGACCCCCGCATCAAGAACCAGCGTGAC
TGCATCCCTTTCTTCCGCTCGGCACCCTCATGCCCCCAAAACAAGAACAGAGTCCGCAAC
CAGATCAACGCGCTCACCTCCTTTGTGGACGCCAGCATGGTGTATGGCAGTGAGGTCTCC
CTCTCGCTGCGGCTCCGCAACCGGACCAACTACCTGGGGCTGCTGGCCATCAACCAGCGC
TTTCAAGACAACGGCCGGGCCCTGCTGCCCTTCGACAACCTGCACGATGACCCCTGTCTC
CTCACCAACCGCTCGGCGCGCATCCCCTGCTTCCTGGCAGGTGACACCCGATCAACGGAA
ACCCCCAAACTGGCAGCCATGCACACCCTCTTTATGCGAGAGCACAACCGGCTGGCCACC
GAGCTGAGACGCCTGAATCCCCGGTGGAATGGAGACAAACTGTACAATGAGGCTCGGAAG
ATCATGGGGGCCATGGTCCAGATCATCACCTACCGAGACTTTCTGCCCCTGGTTCTGGGC
AAGGCCCGGGCCAGGAGAACCCTGGGGCACTACAGGGGGTACTGCTCCAATGTGGACCCA
CGGGTGGCCAATGTCTTCACCCTGGCCTTCCGCTTTGGCCACACAATGCTCCAGCCCTTC
ATGTTCCGCTTGGACAGTCAGTACCGGGCCTCCGCACCCAACTCGCATGTCCCACTTAGC
TCTGCCTTCTTTGCCAGCTGGCGGATCGTGTATGAAGGGGGCATCGACCCCATCCTCCGG
GGCCTCATGGCCACCCCTGCCAAGCTGAACCGTCAGGATGCCATGTTAGTGGATGAGCTC
CGGGACCGGCTGTTTCGGCAAGTGAGGAGGATTGGGCTGGACCTGGCAGCTCTCAACATG
CAACGAAGCCGGGACCACGGCCTTCCAGGGTACAATGCTTGGAGGCGCTTCTGTGGGCTC
TCCCAGCCCCGGAATTTGGCACAGCTTAGCCGGGTGCTGAAAAACCAGGACTTGGCAAGG
AAGTTCCTGAATTTGTATGGAACACCTGACAACATTGACATCTGGATTGGGGCCATCGCT
GAGCCTCTTTTGCCGGGGGCTCGAGTGGGGCCTCTTCTGGCTTGTCTGTTCGAGAACCAG
TTCAGAAGAGCCCGAGACGGAGACAGGTTCTGGTGGCAGAAACGAGGTGTTTTCACCAAA
AGACAGCGCAAGGCCCTGAGCAGAATTTCCTTGTCTCGAATTATATGTGACAATACCGGT
ATCACCACGGTTTCAAGGGACATCTTCAGAGCCAACATCTACCCTCGGGGCTTTGTGAAC
TGCAGCCGTATCCCCAGGTTGAACCTATCAGCCTGGCGAGGGACATGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M29913

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_1_Locus:
17q23.1

# Metabolic_Enzyme_1_SNPs:
rs11079339; rs2302311; rs11652709; rs33971258; rs33955150; rs35135976; rs34817773; rs34553736; rs35750729; rs35617692; rs2240815; rs33979458; rs35979397; rs34607215; rs35419219; rs34599426; rs12602891; rs35844881; rs11079340; rs9892223; rs8077426; rs10853004; rs12602498; rs35620058; rs16942821; rs3785496; rs17222131; rs34415223; rs34489936; rs34621939; rs34467121; rs35601356; rs34225527; rs35892171; rs34409274; rs35700737; rs34630438; rs35005272; rs36066186; rs35706110; rs34137093; rs35352002; rs34630974; rs34421287; rs36098226; rs34139955; rs35974634; rs34270809; rs35223829; rs35707074; rs35219654; rs33954589; rs35212966; rs35209704; rs34212868; rs34898935; rs7224829; rs9891461; rs34102213; rs9895340; rs35074452; rs35832094; rs35896669; rs35232062; rs34883182; rs3922310; rs34444359; rs35584824; rs34519902; rs34433459; rs3785495; rs41561914; rs34021481; rs35062441; rs34704928; rs33963229; rs2333143; rs34555545; rs8078707; rs35755602; rs34441210; rs12952084; rs35552012; rs36011493; rs34390300; rs34570969; rs35143529; rs34209988; rs35036774; rs34141323; rs7222982; rs41544715; rs41558615; rs34820204; rs34999393; rs34554286; rs12947423; rs41541513; rs3760170; rs35722136; rs34702287; rs34690449; rs1045619; rs11548967; rs12103876; rs16942800; rs16942826; rs16942829; rs2191243; rs2191244; rs2302312; rs2302313; rs3213698; rs34560289; rs34631184; rs35184412; rs35464956; rs3744105; rs3760171; rs3785494; rs3826300; rs6503851; rs6503852; rs7210200; rs8067411; rs8067752; rs8068965; rs8071411; rs917606; rs9901765; rs9902640; rs9906421; rs9913536; rs9915578

# Metabolic_Enzyme_1_General_References:
2550461; 2541222; 10358043; 7809065

# Metabolic_Enzyme_1_References:
12114996; 1847342; 8369336

# Macromolecular_Interacting_Partner_1_ID:
7113

# Macromolecular_Interacting_Partner_1_Name:
Cytochrome c

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
CYCS

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Cytochrome c
MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSYTAANKNKGIIW
GEDTLMEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNE

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
105

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
11749

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
10.16

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  binding
Function:  tetrapyrrole binding
Function:  heme binding
Function:  transporter activity
Function:  electron transporter activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Energy production and conversion 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00034:Cytochrom_C

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
181242

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
CYC_HUMAN (P99999)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
CYCS

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
CYCS

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:19986

# Macromolecular_Interacting_Partner_1_PDB_ID:
1J3S

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>318 bp
ATGGGTGATGTTGAGAAAGGCAAGAAGATTTTTATTATGAAGTGTTCCCAGTGCCACACC
GTTGAAAAGGGAGGCAAGCACAAGACTGGGCCAAATCTCCATGGTCTCTTTGGGCGGAAG
ACAGGTCAGGCCCCTGGATACTCTTACACAGCCGCCAATAAGAACAAAGGCATCATCTGG
GGAGAGGATACACTGATGGAGTATTTGGAGAATCCCAAGAAGTACATCCCTGGAACAAAA
ATGATCTTTGTCGGCATTAAGAAGAAGGAAGAAAGGGCAGACTTAATAGCTTATCTCAAA
AAAGCTACTAATGAGTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M22877

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_1_Locus:
7p15.2

# Macromolecular_Interacting_Partner_1_SNPs:
rs11769363; rs7810784; rs1861525; rs12700584; rs10215217; rs4719799; rs12700583; rs12700582; rs3846998; rs2107123; rs11548785; rs11548815; rs11548798; rs11548802; rs11548799; rs11548820; rs11548772; rs11548783; rs11548796; rs11548816; rs11548795; rs3211452; rs11548791; rs11548818; rs11548805; rs3211451; rs11548807; rs11548778; rs17851278; rs11548812; rs11548776; rs11548797; rs11548779; rs11548806; rs11548774; rs11548777; rs11427893; rs1137513; rs3173604; rs11548775; rs1060389; rs1137505; rs1137510; rs11548804; rs1801082; rs1060388; rs1137506; rs11548773; rs41275976; rs1137512; rs1137508; rs13310377; rs13310456; rs34522469; rs35325343; rs1137507; rs11548787; rs1137511; rs10230102; rs11548792; rs28376346; rs1137509; rs36061386; rs6967260; rs3040291; rs16873757; rs5882962; rs34102874; rs34500218; rs10238032; rs17150957; rs10278815; rs10279024; rs10951046; rs11489282; rs12700580; rs2107121; rs2107122; rs2391087; rs2717885; rs2717886

# Macromolecular_Interacting_Partner_1_General_References:
2849112; 12853948; 9515723

# Macromolecular_Interacting_Partner_1_References:
10328816; 10816100; 11396923; 12686420

# Macromolecular_Interacting_Partner_2_ID:
7629

# Macromolecular_Interacting_Partner_2_Name:
Alpha-amylase 2B precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
1,4-alpha-D-glucan glucanohydrolase; Alpha-amylase carcinoid

# Macromolecular_Interacting_Partner_2_Gene_Name:
AMY2B

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Alphaamylase 2B precursor
MKFFLLLFTIGFCWAQYSPNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPP
NENVAIHNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMSGN
AVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLVGL
LDLALEKDYVRSKIAEYMNHLIDIGVAGFRLDASKHMWPGDIKAILDKLHNLNSNWFPAG
SKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWG
FMPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWP
RQFQNGNDVNDWVGPPNNNGVIKEVTINPDTTCGNDWVCEHRWRQIRNMVNFRNVVDGQP
FTNWYDNGSNQVAFGRGNRGFIVFNNDDWTFSLTLQTGLPAGTYCDVISGDKINGNCTGI
KIYVSDDGKAHFSISNSAEDPFIAIHAESKL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
511

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
57710

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
7.10

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  amylase activity
Function:  alpha-amylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_2_Specific_Function:
Endohydrolysis of 1,4-alpha-D-glucosidic linkages in oligosaccharides and polysaccharides

# Macromolecular_Interacting_Partner_2_Pathway:
map00500  Starch and sucrose metabolism

# Macromolecular_Interacting_Partner_2_Reaction:
Endohydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides containing three or more 1,4-alpha-linked D-glucose units

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00128:Alpha-amylase;
PF02806:Alpha-amylase_C

# Macromolecular_Interacting_Partner_2_Signals:
1-15

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
EC 3.2.1.1

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
537512

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
AMYC_HUMAN (P19961)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
AMY2B

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
AMY2B

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:478

# Macromolecular_Interacting_Partner_2_PDB_ID:
1B2Y

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1536 bp
ATGAAGTTCTTTCTGTTGCTTTTCACCATTGGGTTCTGCTGGGCTCAGTATTCCCCAAAT
ACACAACAAGGACGGACATCTATTGTTCATCTGTTTGAATGGCGATGGGTTGATATTGCT
CTTGAATGTGAGCGATATTTAGCTCCCAAGGGATTTGGAGGGGTTCAGGTCTCTCCACCA
AATGAAAATGTTGCAATTCACAACCCTTTCAGACCTTGGTGGGAAAGATACCAACCAGTT
AGCTATAAATTATGCACAAGATCTGGAAATGAAGATGAATTTAGAAACATGGTGACTAGA
TGTAACAATGTTGGGGTTCGTATTTATGTGGATGCTGTAATTAATCATATGTCTGGTAAT
GCTGTGAGTGCAGGAACAAGCAGTACCTGTGGAAGTTACTTCAACCCTGGAAGTAGGGAC
TTTCCAGCAGTCCCATATTCTGGATGGGATTTTAATGATGGTAAATGTAAAACTGGAAGT
GGAGATATCGAGAACTACAATGATGCTACTCAGGTCAGAGATTGTCGTCTGGTTGGTCTT
CTTGATCTTGCACTGGAGAAAGATTATGTGCGTTCCAAGATTGCCGAATATATGAATCAT
CTCATTGACATTGGTGTTGCAGGGTTCAGACTTGATGCTTCCAAGCACATGTGGCCTGGA
GACATAAAGGCAATTTTGGACAAACTGCATAATCTAAACAGTAACTGGTTCCCTGCAGGA
AGTAAACCTTTCATTTACCAGGAGGTAATTGATCTGGGTGGTGAGCCAATTAAAAGCAGT
GACTACTTTGGAAATGGCCGGGTGACAGAATTCAAGTATGGTGCAAAACTCGGCACAGTT
ATTCGCAAGTGGAATGGAGAGAAGATGTCTTACCTAAAGAACTGGGGAGAAGGTTGGGGT
TTCATGCCTTCTGACAGAGCACTTGTCTTTGTGGATAACCATGACAATCAACGAGGACAT
GGGGCTGGAGGAGCCTCTATTCTTACCTTCTGGGATGCTAGGCTGTATAAAATGGCAGTT
GGATTTATGCTTGCTCATCCTTATGGTTTTACACGAGTAATGTCAAGCTACCGTTGGCCA
AGACAGTTTCAAAATGGAAACGATGTTAATGATTGGGTTGGGCCACCAAATAATAATGGA
GTAATTAAAGAAGTTACTATTAATCCAGACACTACTTGTGGCAATGACTGGGTCTGTGAA
CATCGATGGCGCCAAATAAGGAACATGGTTAATTTCCGCAATGTAGTGGATGGCCAGCCT
TTTACAAACTGGTATGATAATGGGAGCAACCAAGTGGCTTTTGGGAGAGGAAACAGAGGA
TTCATTGTTTTCAACAATGATGACTGGACATTTTCTTTAACTTTGCAAACTGGTCTTCCT
GCTGGCACATACTGTGATGTCATTTCTGGAGATAAAATTAATGGCAATTGCACAGGCATT
AAAATCTACGTTTCTGACGATGGCAAAGCTCATTTTTCTATTAGTAACTCTGCTGAGGAT
CCATTTATTGCAATTCATGCTGAATCTAAATTATAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M24895

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_2_Locus:
1p21

# Macromolecular_Interacting_Partner_2_SNPs:
rs1827334; rs7515452; rs10159229; rs12132911; rs11802930; rs11807489; rs17014913; rs4847096; rs2050592; rs17014907; rs6690291; rs12127290; rs17014910; rs12071389; rs17014917; rs9435607; rs7537183; rs12075225; rs516220; rs1832272; rs12085609; rs12075462; rs4098273; rs12128421; rs17851840; rs12131520; rs12062800; rs34357254; rs34598188; rs34459366; rs35720318; rs10623601; rs35095529; rs17532330; rs35335626; rs35734672; rs12743236; rs10624009; rs11184461; rs34578057; rs35902835; rs35996562; rs10609513; rs35347903; rs3762407; rs34248329; rs2316139; rs41277630; rs34485152; rs1856085; rs518097; rs41277628; rs554640; rs35859599; rs1832274; rs2316142; rs2873083; rs2316144; rs35914204; rs1832273; rs41277632; rs12131720; rs12132040; rs2316140; rs1060309; rs11184430; rs11184556; rs11582747; rs12402008; rs12564834; rs17014930; rs17467099; rs3748782; rs484448; rs4847151; rs506047; rs509478; rs511231; rs533214; rs555665; rs556403; rs557287; rs561820; rs562769; rs563036; rs567373; rs6661612; rs6679172

# Macromolecular_Interacting_Partner_2_General_References:
2701942; 2401405; 2452973; 3260028; 8268204

# Macromolecular_Interacting_Partner_2_References:
10792656; 16347742; 3094447

# Macromolecular_Interacting_Partner_3_ID:
7556

# Macromolecular_Interacting_Partner_3_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_3_Signals:
1-18

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_3_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_3_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_3_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_3_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_3_References:
10828724; 10928270

# Macromolecular_Interacting_Partner_4_ID:
8369

# Macromolecular_Interacting_Partner_4_Name:
Oxidoreductase

# Macromolecular_Interacting_Partner_4_Synonyms:
Hydroxysteroid; 17-betadehydrogenase 6; 3- hydroxysteroid epimerase

# Macromolecular_Interacting_Partner_4_Gene_Name:
HSD17B6

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Oxidoreductase
MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC
LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT
LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK
YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ
QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS
LADYILTRSWPKPAQAV

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
317

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
35966

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.91

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Lipid transport and metabolism 

# Macromolecular_Interacting_Partner_4_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00106:adh_short

# Macromolecular_Interacting_Partner_4_Signals:
1-25

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
2338748

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
O14756_HUMAN (O14756)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
HSD17B6

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
HSD17B6

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:23316

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>954 bp
ATGTGGCTCTACCTGGCAGCCTTCGTGGGCCTGTACTACCTTCTGCACTGGTACCGGGAG
AGGCAGGTGGTGAGCCACCTCCAAGACAAGTATGTCTTTATCACGGGCTGTGACTCGGGC
TTTGGGAACCTACTGGCCAGACAGCTGGATGCACGAGGCTTGAGAGTGCTGGCTGCGTGT
CTGACGGAGAAGGGGGCCGAGCAGCTGAGGGGCCAGACGTCTGACAGGCTGGAGACGGTG
ACCCTGGATGTTACCAAGATGGAGAGCATCGCTGCAGCTACTCAGTGGGTGAAGGAGCAT
GTGGGGGACAGAGGACTCTGGGGACTGGTGAACAATGCAGGCATTCTTACACCAATTACC
TTATGTGAGTGGCTGAACACTGAGGACTCTATGAATATGCTCAAAGTGAACCTCATTGGT
GTGATCCAGGTGACCTTGAGCATGCTTCCTTTGGTGAGGAGAGCACGGGGAAGAATTGTC
AATGTCTCCAGCATTCTGGGAAGAGTTGCTTTCTTTGTAGGAGGCTACTGTGTCTCCAAG
TATGGAGTGGAAGCCTTTTCAGATATTCTGAGGCGTGAGATTCAACATTTTGGGGTGAAA
ATCAGCATAGTTGAACCTGGCTACTTCAGAACGGGAATGACAAACATGACACAGTCCTTA
GAGCGAATGAAGCAAAGTTGGAAAGAAGCCCCCAAGCATATTAAGGAGACCTATGGACAG
CAGTATTTTGATGCCCTTTACAATATCATGAAGGAAGGGCTGTTGAATTGTAGCACAAAC
CTGAACCTGGTCACTGACTGCATGGAACATGCTCTGACATCGGTGCATCCGCGAACTCGA
TATTCAGCTGGCTGGGATGCTAAATTTTTCTTCATCCCTCTATCTTATTTACCTACATCA
CTGGCAGACTACATTTTGACTAGATCTTGGCCCAAACCAGCCCAGGCAGTCTAA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
AF016509

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_4_Locus:
12q13

# Macromolecular_Interacting_Partner_4_SNPs:
rs898611; rs7967600; rs7980317; rs11835916; rs12229709; rs12227131; rs12809466; rs12227117; rs7295862; rs10876921; rs10459247; rs10459246; rs10876920; rs11830415; rs4277148; rs2371628; rs12229899; rs10747770; rs11832786; rs10876919; rs4759256; rs35174136; rs35329345; rs10538536; rs5798394; rs12366563; rs35348347; rs34561077; rs34270146; rs5798395; rs11171967; rs35753038; rs12828479; rs35374137; rs34769799; rs11171966; rs12229409; rs34937784; rs35897287; rs34249257; rs12317442; rs10876922; rs34522994; rs11171968; rs11171969; rs28564526; rs3816616; rs35988358; rs34194340; rs12300153; rs34050360; rs34383378; rs11407460; rs12826939; rs11835254; rs35582861; rs12827132; rs4578426; rs6581104; rs7313074

# Macromolecular_Interacting_Partner_4_General_References:
9188497; 11360992; 12477932; 10896656

# Macromolecular_Interacting_Partner_4_References:
11997012

# Macromolecular_Interacting_Partner_5_ID:
7887

# Macromolecular_Interacting_Partner_5_Name:
CDNA FLJ90651 fis, clone PLACE1004482, highly similar to Plasma glutamate carboxypeptidase

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>CDNA FLJ90651 fis, clone PLACE1004482, highly similar to Plasma glutamate carboxypeptidase
MKFLIFAFFGGVHLLSLCSGKAICKNGISKRTFEEIEEEIASCGDVAKAIINLAVYGKAQ
NRSYERLALLVDTVGPRLSGSKNLEKAIQIMYQNLQQDGLEKVHLEPVRIPHWERGGESA
VMLEPRIHKIAILGLGSSIGTPPEGITAEVLVVTSFDELQRRASEARGKIVVYNQPYINY
SRTVQYRTQGAVEAAKVGALASLIRSVASFSIYSPHTGIQEYQDGVPKIPTACITVEDAE
MMSRMASHGIKIVIQLKMGAKTYPDTDSFNTVAEITGSKYPEQVVLVSGHLDSWDVGQGA
MDDGGGAFISWEALSLIKDLGLRPKRTLRLVLWTAEEQGGVGAFQYYQLHKVNISNYSLV
MESDAGTFLPTGLQFTGSEKARAIVEEVMSLLQPLNITQVLSHGEGTDINFWIQAGVPGA
SLLDDLYKYFFFHHSHGDTMTVMDPKQMNVAAAVWAVVSYVVADMEEMLPRS

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
472

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
51785

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
5.95

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF04389:Peptidase_M28

# Macromolecular_Interacting_Partner_5_Signals:
1-20

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
22761023

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
Q8NBZ1_HUMAN (Q8NBZ1)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_5_hgnc_id:
Not Available

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1419 bp
ATGAAATTCCTTATCTTCGCATTTTTCGGTGGTGTTCACCTTTTATCCCTGTGCTCTGGG
AAAGCTATATGCAAGAATGGCATCTCTAAGAGGACTTTTGAAGAAATAGAAGAAGAAATA
GCCAGCTGTGGAGATGTTGCTAAAGCAATCATCAACCTAGCTGTTTATGGTAAAGCCCAG
AACAGATCCTATGAGCGATTGGCACTTCTGGTTGATACTGTTGGACCCAGACTGAGTGGC
TCCAAGAACCTAGAAAAAGCCATCCAAATTATGTACCAAAACCTGCAGCAAGATGGGCTG
GAGAAAGTTCACCTGGAGCCAGTGAGAATACCCCACTGGGAGAGGGGAGGAGAATCAGCT
GTGATGCTGGAGCCAAGAATTCATAAGATAGCCATCCTGGGTCTTGGCAGCAGCATTGGG
ACTCCTCCAGAAGGCATTACAGCAGAAGTTCTGGTGGTGACCTCTTTCGATGAACTGCAG
AGAAGGGCCTCAGAAGCAAGAGGGAAGATTGTTGTTTATAACCAACCTTACATCAACTAC
TCAAGGACGGTGCAATACCGAACGCAGGGGGCGGTGGAAGCTGCCAAGGTTGGGGCTTTG
GCATCTCTCATTCGATCCGTGGCCTCCTTCTCCATCTACAGTCCTCACACAGGTATTCAG
GAATACCAGGATGGCGTGCCCAAGATTCCAACAGCCTGTATTACGGTGGAAGATGCAGAA
ATGATGTCAAGAATGGCTTCTCATGGGATCAAAATTGTCATTCAGCTAAAGATGGGGGCA
AAGACCTACCCAGATACTGATTCCTTCAACACTGTAGCAGAGATCACTGGGAGCAAATAT
CCAGAACAGGTTGTACTGGTCAGTGGACATCTGGACAGCTGGGATGTTGGGCAGGGTGCC
ATGGATGATGGCGGTGGAGCCTTTATATCATGGGAAGCACTCTCACTTATTAAAGATCTT
GGGCTGCGTCCAAAGAGGACTCTGCGGCTGGTGCTCTGGACTGCAGAAGAACAAGGTGGA
GTTGGTGCCTTCCAGTATTATCAGTTACACAAGGTAAATATTTCCAACTACAGTCTGGTG
ATGGAGTCTGACGCAGGAACCTTCTTACCCACTGGGCTGCAATTCACTGGCAGTGAAAAG
GCCAGGGCCATCGTGGAGGAGGTTATGAGCCTGCTGCAGCCCCTCAATATCACTCAGGTC
CTGAGCCATGGAGAAGGGACAGACATCAACTTTTGGATCCAAGCTGGAGTGCCTGGAGCC
AGTCTACTTGATGACTTATACAAGTATTTCTTCTTCCATCACTCCCACGGAGACACCATG
ACTGTCATGGATCCAAAGCAGATGAATGTTGCTGCTGCTGTTTGGGCTGTTGTTTCTTAT
GTTGTTGCAGACATGGAAGAAATGCTGCCTAGGTCCTAG

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AK075132

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Locus:
Not Available

# Macromolecular_Interacting_Partner_5_SNPs:
Not Available

# Macromolecular_Interacting_Partner_5_General_References:
Not Available

# Macromolecular_Interacting_Partner_5_References:
10480331

End of HMDB00055

Beginning of HMDB00056
# Accession_No:
HMDB00056

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-19 10:17:25

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
beta-Alanine

# Description:
An amino acid formed in vivo by the degradation of dihydrouracil and carnosine.  It is a component of the naturally occurring peptides carnosine and anserine and also of pantothenic acid (Vitamin B-5) which itself is a component of coenzyme A. Under normal conditions, beta-alanine is metabolized into acetic acid. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. A rare genetic disorder, hyper-beta-alaninemia, has been reported.

# Synonyms:
2-Carboxyethylamine; 3-Aminopropanoate; 3-Aminopropanoic acid; 3-Aminopropionate; 3-Aminopropionic acid; 3-amino-Propanoate; 3-amino-Propanoic acid; Abufene; B-Alanine; b-Aminopropanoate; b-Aminopropanoic acid; b-Aminopropionate; b-Aminopropionic acid; beta Alanine; beta-Alanine; beta-Aminopropionate; beta-Aminopropionic acid; omega-Aminopropionate; omega-Aminopropionic acid; beta-Aminopropanoate; beta-Aminopropanoic acid

# Chemical_IUPAC_Name:
3-aminopropanoic acid

# Chemical_Formula:
C3H7NO2

# Chemical_Structure:
tbl_chemical:::HMDB00056_ZOOM.png:::119283162061634516

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00056_THUMB.png:::119283161888688981

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid

# Taxonomy_Biofunction:
Component of beta-Alanine metabolism; Component of Pantothenate and CoA biosynthesis; Component of Pyrimidine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
89.04768

# Molecular_Weight_Avg:
89.09318

# Smiles_String_isomeric:
NCCC(O)=O

# Smiles_String_canonical:
NCCC(O)=O

# KEGG_Compound_ID:
C00099

# BioCyc_ID:
B-ALANINE

# PubChem_CID:
239

# PubChem_SID:
11113405; 73438; 5337095; 841408; 589755; 8144745; 3136373; 151007; 10503561; 2158; 10317433; 827137; 10323899; 608061; 8137904; 827130; 7978774; 3399; 10517185; 7988276; 718545; 8150523; 7886061

# OMIM_ID:
109660; 137150; 237400; 274270; 603178

# Metagene_ID:
Not Available

# BiGG_ID:
33848

# Wikipedia_ID:
Not Available

# METLIN_ID:
5119

# Ref_ID:
14705962; 2894959; 9829262; 7179210; 15284084; 679461; 15385443; 3829006; 12067239; 3983897; 8203202; 16282220; 16554972; 2296474; 200005; 2119585

# ChEBI_ID:
16958

# CAS_Registry_Number:
107-95-9

# InChI:
InChI=1/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6)

# Synthesis_Reference:
Journal of the American Chemical Society  (1945),  67  92-4.

# Melting_Point:
200 oC

# Melting_Point_predicted:
25.4 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
545.0 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
494.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-3.05 [TSAI,RS ET AL. (1991)]

# LogP_predicted:
-3.25 [Predicted by ALOGPS]; -1 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::b-Alanine.pdf:::1132562194851615556

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::B-Alanine.mol:::1132723804078468029

# SDF_File_[Text]:
tbl_chemical:::HMDB00056.sdf:::119283161562121357

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00056.pdb:::11928316172591422

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::107-95-9presatB.gif:::114227101465794982

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::050110_P00_01_IS_1DP_PRESAT_1.zip:::114460782935038644

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::050110_P00_01_IS_1DP_Assigned.png:::114669000274233033

# C_NMR_Spectra:
tbl_cnmr:::050110_P00_01_IS_1DC_63.jpg:::114168392360822427

# C_NMR_FIDS_Spectra:
tbl_cnmr:::050110_P00_01_IS_1DC_63.zip:::114168392357690847

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::050110_P00_01_IS_1DC_63_Assigned.jpg:::114322782526890921

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050110_P00_01_IS_2DHSQC_204.jpg:::114495469196797638

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050110_P00_01_IS_2DHSQC_204.zip:::114495469199363139

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050110_P00_01_IS_2DHSQC_204_Assigned.jpg:::1144954692197149

# Predicted_H_NMR_Spectrum:
tbl_chemical:::B-Alanine.gif:::1132732103718703042

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00056_peaks.txt:::1156309516298982696

# Predicted_C_NMR_Spectrum:
tbl_chemical:::B-Alanine_C.gif:::1132737670165364965

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00056_peaks.txt:::115631070677042962

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00056L.png:::117555261909643648; Medium Energy:tbl_ms:::HMDB00056M.png:::11755526703831108; High Energy:tbl_ms:::HMDB00056H.png:::117555270900872606

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000159.png:::116907444260926749

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000159.txt:::116907444260973706

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000159.png:::116890829490651261

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000159.txt:::116890829515650776

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria

# Tissue_Location:
Kidney; Muscle; Pancreas; Placenta

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	2.4 +/- 3.0	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	14705962
Blood	3.8 +/- 2.9	uM	Adult:>18_yrs_old	Both	Normal	14705962
Blood	3.00 +/- 0.85	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 80-95. Edited by Cornelius Lentner. ; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. ; Basle, Switzerland c1981-1992.
Blood	1.76 +/- 0.74	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 80-95. Edited by Cornelius Lentner. ; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. ; Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	0.024 +/- 0.013	uM	Adult:>18_yrs_old	Both	Normal	14705962


# Concentration_[Abnormal]:
Urine	1.4 +/- 1.4	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Dihydropyrimidine dehydrogenase (DPD) deficiency	14705962
Blood	2.7 +/- 1.3	uM	Adult:>18_yrs_old	Both	Dihydropyrimidine dehydrogenase (DPD) deficiency	14705962
Cerebrospinal_Fluid(CSF)	0.036 +/- 0.034	uM	Adult:>18_yrs_old	Both	Dihydropyrimidine dehydrogenase (DPD) deficiency	14705962


# Associated_Disorders:
Alzheimer's Disease; Dihydropyrimidine dehydrogenase (DPD) deficiency; Hyper-Beta-Alaninemia; Startle Disease (Hyperekplexia)

# Pathway_Names:
Alanine and aspartate metabolism;Butanoate metabolism;Glycolysis;Fatty acid metabolism;Bile acid biosynthesis;Valine, leucine and isoleucine degradation;Lysine degradation;Glycerolipid metabolism;Pyruvate metabolism;Propanoate metabolism;Pantothenate and CoA biosynthesis;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
Aspartate_and_Alanine_metabolism.jpg;;Glycolysis.jpg;;;valine,leucine,and_isoleucine_degradation.jpg;Lysine_degradation.jpg;;;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00252;map00650;map00010;map00071;map00120;map00280;map00310;map00561;map00620;map00640;map00770;map00280;map00280

# Pathway_Graphs:
Aspartate_and_Alanine_metabolism_Graph.jpg;;Glycolysis_Graph.jpg;;;valine,leucine,and_isoleucine_degradation_Graph.jpg;Lysine_degradation_Graph.jpg;;;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
Aspartate_and_Alanine_metabolism.xml;;Glycolysis.xml;;;valine,leucine,and_isoleucine_degradation.xml;Lysine_degradation.xml;;;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5975

# Metabolic_Enzyme_1_Name:
Glutamate decarboxylase 2

# Metabolic_Enzyme_1_Synonyms:
Glutamate decarboxylase 65 kDa isoform; GAD-65; 65 kDa glutamic acid decarboxylase

# Metabolic_Enzyme_1_Gene_Name:
GAD2

# Metabolic_Enzyme_1_Protein_Sequence:
>Glutamate decarboxylase 2
MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGG
SQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQ
YVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFN
QLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFS
PGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVI
LIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIW
MHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQ
MHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEY
LYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEY
GTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL

# Metabolic_Enzyme_1_Number_of_Residues:
585

# Metabolic_Enzyme_1_Molecular_Weight:
65412

# Metabolic_Enzyme_1_Theoretical_pI:
6.89

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the production of GABA

# Metabolic_Enzyme_1_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00410  beta-Alanine metabolism;
 map00430  Taurine and hypotaurine metabolism;
 map00650  Butanoate metabolism

# Metabolic_Enzyme_1_Reaction:
L-glutamate = 4-aminobutanoate + CO2

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00282:Pyridoxal_deC

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 4.1.1.15

# Metabolic_Enzyme_1_GenBank_ID_Protein:
182934

# Metabolic_Enzyme_1_SwissProt_ID:
DCE2_HUMAN (Q05329)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
GAD2

# Metabolic_Enzyme_1_Geneatlas_id:
GAD2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4093

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm; cytosol. Cytoplasmic vesicle. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters

# Metabolic_Enzyme_1_Gene_Sequence:
>1758 bp
ATGGCATCTCCGGGCTCTGGCTTTTGGTCTTTCGGGTCGGAAGATGGCTCTGGGGATTCC
GAGAATCCCGGCACAGCGCGAGCCTGGTGCCAAGTGGCTCAGAAGTTCACGGGCGGCATC
GGAAACAAACTGTGCGCCCTGCTCTACGGAGACGCCGAGAAGCCGGCGGAGAGCGGCGGG
AGCCAACCCCCGCGGGCCGCCGCCCGGAAGGCCGCCTGCGCCTGCGACCAGAAGCCCTGC
AGCTGCTCCAAAGTGGATGTCAACTACGCGTTTCTCCATGCAACAGACCTGCTGCCGGCG
TGTGATGGAGAAAGGCCCACTTTGGCGTTTCTGCAAGATGTTATGAACATTTTACTTCAG
TATGTGGTGAAAAGTTTCGATAGATCAACCAAAGTGATTGATTTCCATTATCCTAATGAG
CTTCTCCAAGAATATAATTGGGAATTGGCAGACCAACCACAAAATTTGGAGGAAATTTTG
ATGCATTGCCAAACAACTCTAAAATATGCAATTAAAACAGGGCATCCTAGATACTTCAAT
CAACTTTCTACTGGTTTGGATATGGTTGGATTAGCAGCAGACTGGCTGACATCAACAGCA
AATACTAACATGTTCACCTATGAAATTGCTCCAGTATTTGTGCTTTTGGAATATGTCACA
CTAAAGAAAATGAGAGAAATCATTGGCTGGCCAGGGGGCTCTGGCGATGGGATATTTTCT
CCCGGTGGCGCCATATCTAACATGTATGCCATGATGATCGCACGCTTTAAGATGTTCCCA
GAAGTCAAGGAGAAAGGAATGGCTGCTCTTCCCAGGCTCATTGCCTTCACGTCTGAACAT
AGTCATTTTTCTCTCAAGAAGGGAGCTGCAGCCTTAGGGATTGGAACAGACAGCGTGATT
CTGATTAAATGTGATGAGAGAGGGAAAATGATTCCATCTGATCTTGAAAGAAGGATTCTT
GAAGCCAAACAGAAAGGGTTTGTTCCTTTCCTCGTGAGTGCCACAGCTGGAACCACCGTG
TACGGAGCATTTGACCCCCTCTTAGCTGTCGCTGACATTTGCAAAAAGTATAAGATCTGG
ATGCATGTGGATGCAGCTTGGGGTGGGGGATTACTGATGTCCCGAAAACACAAGTGGAAA
CTGAGTGGCGTGGAGAGGGCCAACTCTGTGACGTGGAATCCACACAAGATGATGGGAGTC
CCTTTGCAGTGCTCTGCTCTCCTGGTTAGAGAAGAGGGATTGATGCAGAATTGCAACCAA
ATGCATGCCTCCTACCTCTTTCAGCAAGATAAACATTATGACCTGTCCTATGACACTGGA
GACAAGGCCTTACAGTGCGGACGCCACGTTGATGTTTTTAAACTATGGCTGATGTGGAGG
GCAAAGGGGACTACCGGGTTTGAAGCGCATGTTGATAAATGTTTGGAGTTGGCAGAGTAT
TTATACAACATCATAAAAAACCGAGAAGGATATGAGATGGTGTTTGATGGGAAGCCTCAG
CACACAAATGTCTGCTTCTGGTACATTCCTCCAAGCTTGCGTACTCTGGAAGACAATGAA
GAGAGAATGAGTCGCCTCTCGAAGGTGGCTCCAGTGATTAAAGCCAGAATGATGGAGTAT
GGAACCACAATGGTCAGCTACCAACCCTTGGGAGACAAGGTCAATTTCTTCCGCATGGTC
ATCTCAAACCCAGCGGCAACTCACCAAGACATTGACTTCCTGATTGAAGAAATAGAACGC
CTTGGACAAGATTTATAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M81882

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_1_Locus:
10p11.23

# Metabolic_Enzyme_1_SNPs:
rs2839672; rs2839678; rs1805397; rs2229845; rs7919405; rs1556234; rs3781106; rs8190809; rs1335547; rs3781105; rs3781107; rs8190811; rs8190812; rs8190817; rs8190816; rs8190800; rs8190590; rs8190813; rs8190805; rs8190801; rs7073217; rs8190802; rs8190814; rs8190807; rs8190815; rs8190803; rs992990; rs2368160; rs2368159; rs913963; rs913964; rs1999241; rs870341; rs928197; rs8190604; rs7906725; rs3781109; rs6482551; rs1330581; rs8190764; rs4749108; rs6482541; rs7897510; rs8190780; rs7071922; rs3893052; rs6482537; rs7073119; rs7900739; rs2839671; rs3781108; rs11015008; rs12267286; rs4994426; rs7893400; rs1330582; rs8190754; rs7087663; rs7900976; rs12414701; rs7074534; rs4144102; rs7074235; rs7068224; rs3847380; rs3781113; rs7902107; rs7076544; rs6482540; rs7913676; rs7908975; rs6482550; rs3781117; rs4747548; rs8190748; rs4749105; rs8190706; rs8190704; rs7087011; rs3781114; rs4749101; rs3847378; rs7893194; rs4747550; rs7913524; rs4749102; rs8190798; rs4749107; rs7095327; rs4747547; rs4747549; rs3847379; rs6482538; rs8190598; rs3824694; rs17667367; rs8190658; rs3781111; rs7081084; rs11015015; rs8190694; rs7897355; rs8190734; rs3904297; rs10828963; rs928198; rs913962; rs11015025; rs8190624; rs7099569; rs7918935; rs7072964; rs8190628; rs11015024; rs8190714; rs4749103; rs8190690; rs8190635; rs3781112; rs2839676; rs7909909; rs8190720; rs8190645; rs16926761; rs8190770; rs11594057; rs870342; rs6482544; rs7898281; rs1935996; rs8190708; rs8190716; rs3904298; rs8190597; rs8190779; rs3781116; rs12253114; rs8190660; rs7089304; rs3893253; rs7074934; rs2839675; rs8190796; rs4749104; rs12098763; rs7080514; rs8190685; rs7067571; rs6482543; rs7068510; rs8190611; rs12242971; rs1805398; rs7072137; rs8190689; rs8190646; rs11015010; rs11015028; rs8190718; rs2298124; rs2839674; rs8190713; rs7100268; rs6482548; rs7903208; rs7078680; rs1805399; rs8190678; rs8190701; rs8190612; rs3781118; rs3904296; rs8190637; rs8190683; rs8190673; rs8190782; rs7079102; rs6482542; rs11015004; rs12258601; rs12263667; rs7909902; rs8190620; rs8190650; rs7911425; rs6482547; rs913965; rs8190794; rs8190741; rs8190621; rs7895479; rs1330579; rs8190786; rs8190665; rs8190594; rs8190778; rs8190656; rs16926784; rs8190618; rs8190675; rs8190711; rs8190739; rs7091779; rs8190616; rs8190648; rs8190763; rs8190661; rs11015012; rs8190773; rs12248404; rs8190641; rs8190746; rs8190757; rs8190668; rs12358823; rs8190776; rs8190750; rs8190697; rs11015016; rs7067786; rs8190695; rs8190623; rs12258107; rs6482539; rs8190723; rs8190797; rs8190738; rs8190765; rs8190787; rs7915657; rs7912687; rs12251044; rs10828964; rs8190608; rs8190667; rs8190596; rs16926747; rs8190781; rs8190642; rs8190639; rs8190751; rs8190784; rs8190627; rs3781110; rs8190696; rs8190703; rs12254792; rs8190593; rs8190715; rs8190737; rs8190634; rs8190727; rs10160178; rs12098764; rs8190771; rs8190736; rs8190682; rs2839677; rs8190651; rs8190785; rs11015018; rs4111544; rs7911393; rs10466096; rs7080693; rs11015003; rs8190709; rs7909127; rs7922748; rs8190733; rs11015017; rs8190602; rs8190672; rs8190789; rs3904299; rs8190692; rs8190626; rs8190632; rs8190774; rs11015002; rs12243085; rs8190768; rs8190722; rs8190617; rs7905275; rs8190752; rs8190595; rs8190728; rs1330580; rs7893528; rs11015011; rs12360108; rs8190607; rs8190772; rs8190766; rs8190693; rs8190647; rs7089218; rs6482549; rs10466098; rs8190756; rs8190775; rs8190744; rs7914135; rs12243037; rs12240863; rs8190758; rs8190670; rs7076905; rs12269473; rs8190721; rs8190606; rs8190615; rs8190649; rs2236418; rs3758446; rs4749111; rs8190582; rs2839669; rs2839670; rs4747553; rs4749110; rs7090727; rs4747551; rs7090581; rs4747552; rs2236417; rs8190586; rs1065239; rs8190588; rs8190825; rs8190585; rs8190587; rs8190584; rs8190823; rs2839673; rs8190730; rs8190671; rs8190600; rs8190591; rs8190729; rs8190799; rs8190804; rs34587935; rs41279918; rs8190818; rs1360845; rs8190821; rs17847106; rs8190806; rs8190819; rs8190820; rs8190810; rs8190808; rs2210118; rs35598312; rs35399576; rs8190609; rs8190724; rs11015005; rs11015026; rs8190753; rs8190747; rs11812646; rs11015007; rs8190731; rs16926771; rs34544929; rs8190783; rs8190680; rs8190742; rs7914958; rs11424034; rs34446027; rs10706901; rs8190687; rs8190795; rs8190792; rs12242900; rs7912720; rs12765251; rs8190638; rs17847108; rs35729928; rs35302027; rs8190674; rs28411087; rs36068216; rs11015021; rs12413327; rs41279916; rs8190760; rs3831349; rs35525470; rs8190702; rs12240533; rs8190759; rs7077030; rs35027140; rs8190657; rs8190743; rs35001308; rs35095406; rs8190664; rs35193512; rs8190676; rs7898671; rs34460749; rs7910714; rs8190610; rs8190601; rs11015029; rs34165540; rs10571094; rs34714031; rs17847113; rs8190655; rs10466097; rs8190691; rs34544347; rs8190788; rs34492981; rs11397236; rs8190640; rs8190767; rs34551923; rs11015013; rs12240390; rs17847119; rs958295; rs7896603; rs8190613; rs11351928; rs8190793; rs35560251; rs8190777; rs12258225; rs4749109; rs35466733; rs8190619; rs12764007; rs8190677; rs8190712; rs8190684; rs8190652; rs8190761; rs11015023; rs8190717; rs3925895; rs12780466; rs35967087; rs10691988; rs41279914; rs8190654; rs35473617; rs7906622; rs8190622; rs8190699; rs8190700; rs35554915; rs8190790; rs8190614; rs34282513; rs7904959; rs35460917; rs35692804; rs35701656; rs5783968; rs41304597; rs8190740; rs11015030; rs7910604; rs12258527; rs4749100; rs8190755; rs12265834; rs7906659; rs7911822; rs8190681; rs11382565; rs10550716; rs8190726; rs41304609; rs7900313; rs12258214; rs8190599; rs11015014; rs8190633; rs8190605; rs11594128; rs7084058; rs8190643; rs35046451; rs7897227; rs35449881; rs11015009; rs35322930; rs35856372; rs35871778; rs11389512; rs8190636; rs11437464; rs8190653; rs35327186; rs35218393; rs8190745; rs34436183; rs11015006; rs35900771; rs8190732; rs8190735; rs12252062; rs7074897; rs8190791; rs8190725; rs8190666; rs8190669; rs8190631; rs8190707; rs8190679; rs8190749; rs34964656; rs34166651; rs35778757; rs8190719; rs8190710; rs8190686; rs35829665; rs11407523; rs8190625; rs11417128; rs8190659; rs36008357; rs16926745; rs8190698; rs8190769; rs11014999; rs8190603; rs8190705; rs7078821; rs11015027; rs8190762; rs8190644; rs4589175; rs8190589; rs8190822; rs8190583; rs34861013; rs10508715; rs11014998; rs11015031; rs11015032; rs11591556; rs12248143; rs12256696; rs12264198; rs12265385; rs1330574; rs16926835; rs16926836; rs1888251; rs2150157; rs2150158; rs2150159; rs2150160; rs2839668; rs7899642; rs7915415; rs7922791; rs8190828; rs8190830; rs876845; rs876846; rs876847; rs876848; rs882138; rs994502

# Metabolic_Enzyme_1_General_References:
1924293; 1549570; 8088791; 7680313; 8243826; 8999827; 12356867

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5976

# Metabolic_Enzyme_2_Name:
Glutamate decarboxylase 1

# Metabolic_Enzyme_2_Synonyms:
Glutamate decarboxylase 67 kDa isoform; GAD-67; 67 kDa glutamic acid decarboxylase

# Metabolic_Enzyme_2_Gene_Name:
GAD1

# Metabolic_Enzyme_2_Protein_Sequence:
>Glutamate decarboxylase 1
MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEK
SRLVSAFKERQSSKNLLSCENSDRDARFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEV
VDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGV
RTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWS
SKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTSEQSHYSIKKAGAA
LGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDPIQEIA
DICEKYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKE
KGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQI
NKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAP
KIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL

# Metabolic_Enzyme_2_Number_of_Residues:
594

# Metabolic_Enzyme_2_Molecular_Weight:
66897

# Metabolic_Enzyme_2_Theoretical_pI:
7.67

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the production of GABA

# Metabolic_Enzyme_2_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00410  beta-Alanine metabolism;
 map00430  Taurine and hypotaurine metabolism;
 map00650  Butanoate metabolism

# Metabolic_Enzyme_2_Reaction:
L-glutamate = 4-aminobutanoate + CO2

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00282:Pyridoxal_deC

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 4.1.1.15

# Metabolic_Enzyme_2_GenBank_ID_Protein:
182936

# Metabolic_Enzyme_2_SwissProt_ID:
DCE1_HUMAN (Q99259)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
GAD1

# Metabolic_Enzyme_2_Geneatlas_id:
GAD1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:4092

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>1785 bp
ATGGCGTCTTCGACCCCATCTTCGTCCGCAACCTCCTCGAACGCGGGAGCGGACCCCAAT
ACCACTAACCTGCGCCCCACAACGTACGATACCTGGTGCGGCGTGGCCCATGGATGCACC
AGAAAACTGGGGCTCAAGATCTGCGGCTTCTTGCAAAGGACCAACAGCCTGGAAGAGAAG
AGTCGCCTTGTGAGTGCCTTCAGGGAGAGGCAATCCTCCAAGAACCTGCTTTCCTGTGAA
AACAGCGACCGGGATGCCCGCTTCCGGCGCACAGAGACTGACTTCTCTAATCTGTTTGCT
AGAGATCTGCTTCCGGCTAAGAACGGTGAGGAGCAAACCGTGCAATTCCTCCTGGAAGTG
GTGGACATACTCCTCAACTATGTCCGCAAGACATTTGATCGCTCCACCAAGGTGCTGGAC
TTTCATCACCCACACCAGTTGCTGGAAGGCATGGAGGGCTTCAACTTGGAGCTCTCTGAC
CACCCCGAGTCCCTGGAGCAGATCCTGGTTGACTGCAGAGACACCTTGAAGTATGGGGTT
CGCACAGGTCATCCTCGATTTTTCAACCAGCTCTCCACTGGATTGGATATTATTGGCCTA
GCTGGAGAATGGCTGACATCAACGGCCAATACCAACATGTTTACATATGAAATTGCACCA
GTGTTTGTCCTCATGGAACAAATAACACTTAAGAAGATGAGAGAGATAGTTGGATGGTCA
AGTAAAGATGGTGATGGGATATTTTCTCCTGGGGGCGCCATATCCAACATGTACAGCATC
ATGGCTGCTCGCTACAAGTACTTCCCGGAAGTTAAGACAAAGGGCATGGCGGCTGTGCCT
AAACTGGTCCTCTTCACCTCAGAACAGAGTCACTATTCCATAAAGAAAGCTGGGGCTGCA
CTTGGCTTTGGAACTGACAATGTGATTTTGATAAAGTGCAATGAAAGGGGGAAAATAATT
CCAGCTGATTTTGAGGCAAAAATTCTTGAAGCCAAACAGAAGGGATATGTTCCCTTTTAT
GTCAATGCAACTGCTGGCACGACTGTTTATGGAGCTTTTGATCCGATACAAGAGATTGCA
GATATATGTGAGAAATATAACCTTTGGTTGCATGTCGATGCTGCCTGGGGAGGTGGGCTG
CTCATGTCCAGGAAGCACCGCCATAAACTCAACGGCATAGAAAGGGCCAACTCAGTCACC
TGGAACCCTCACAAGATGATGGGCGTGCTGTTGCAGTGCTCTGCCATTCTCGTCAAGGAA
AAGGGTATACTCCAAGGATGCAACCAGATGTGTGCAGGATATCTCTTCCAGCCAGACAAG
CAGTATGATGTCTCCTACGACACCGGGGACAAGGCAATTCAGTGTGGCCGCCACGTGGAT
ATCTTCAAGTTCTGGCTGATGTGGAAAGCAAAGGGCACAGTGGGATTTGAAAACCAGATC
AACAAATGCCTGGAACTGGCTGAATACCTCTATGCCAAGATTAAAAACAGAGAAGAATTT
GAGATGGTTTTCAATGGCGAGCCTGAGCACACAAACGTCTGTTTTTGGTATATTCCACAA
AGCCTCAGGGGTGTGCCAGACAGCCCTCAACGACGGGAAAAGCTACACAAGGTGGCTCCA
AAAATCAAAGCCCTGATGATGGAGTCAGGTACGACCATGGTTGGCTACCAGCCCCAAGGG
GACAAGGCCAACTTCTTCCGGATGGTCATCTCCAACCCAGCCGCTACCCAGTCTGACATT
GACTTCCTCATTGAGGAGATAGAAAGACTGGGCCAGGATCTGTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M81883

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_2_Locus:
2q31

# Metabolic_Enzyme_2_SNPs:
rs769402; rs769403; rs41526346; rs769401; rs11542313; rs769395; rs2270335; rs769399; rs3749034; rs1049730; rs3762553; rs769406; rs769409; rs2058725; rs769391; rs769411; rs3791861; rs3791856; rs2270334; rs701492; rs4668331; rs3791857; rs769393; rs3791875; rs3791853; rs3791876; rs2302659; rs3791877; rs769390; rs3791862; rs10439259; rs2234728; rs4668329; rs2241164; rs3791860; rs7561581; rs3791850; rs6716794; rs3791865; rs3791858; rs2241165; rs3791851; rs7578661; rs3828275; rs6433253; rs16858977; rs3791866; rs16858988; rs6433252; rs3749033; rs34210682; rs12612498; rs769405; rs3791871; rs4668330; rs11900444; rs11896169; rs769408; rs3791874; rs3791859; rs4668327; rs41464547; rs41393845; rs1420385; rs1548902; rs41496949; rs1477061; rs11896015; rs701491; rs3791864; rs3791872; rs10930441; rs11890416; rs10191129; rs11895404; rs769407; rs3791855; rs2234727; rs11890409; rs3762556; rs3791878; rs6755370; rs3762557; rs3749035; rs3791879; rs6755371; rs3791880; rs2356236; rs3762554; rs4668324; rs872124; rs3762555; rs1049731; rs1049736; rs17857149; rs17857148; rs1049735; rs34856125; rs34100397; rs1049733; rs1049734; rs35426017; rs3049870; rs5836306; rs34510522; rs34365430; rs35367730; rs35542409; rs954947; rs17752543; rs13017667; rs35495756; rs3791868; rs10698625; rs3049892; rs11338558; rs11331088; rs41265947; rs3791852; rs13035478; rs769394; rs35089719; rs13018052; rs3838551; rs34072956; rs2160415; rs769389; rs34265473; rs13385854; rs2160414; rs11338557; rs34462898; rs13014614; rs35050499; rs3791867; rs4668332; rs13017665; rs3828274; rs35232338; rs34347776; rs13000989; rs35659093; rs4668325; rs10698618; rs34528852; rs3791873; rs7602684; rs12995992; rs35050304; rs6753612; rs35212610; rs10179059; rs35492651; rs3838552; rs7576933; rs41304175; rs34884445; rs10529529; rs13028093; rs35845895; rs41315874; rs28514878; rs3749032; rs3791854; rs35445717; rs769398; rs5836308; rs12991140; rs13014984; rs13033900; rs3791869; rs11333718; rs3791863; rs10605864; rs7594314; rs4667661; rs34291719; rs3791870; rs11314645; rs35495071; rs769410; rs4536622; rs10623405; rs35403424; rs4668326; rs3838550; rs10930442; rs3838553; rs35991368; rs4668328; rs13014595; rs7595288; rs11327360; rs35566565; rs35379843; rs41311313; rs5836305; rs1362492; rs4667659; rs3762558; rs4667660; rs6755102; rs6758358; rs33918896; rs34236419; rs10803852; rs10930443; rs11682957; rs11694200; rs11904485; rs12185692; rs12472230; rs12614879; rs12999141; rs13432752; rs16858996; rs17701824; rs1978340; rs2160413; rs2192987; rs28642888; rs3762560; rs3762561; rs4389303; rs4667662; rs4667663; rs6433254; rs6433255; rs6433256; rs6433257; rs6433261; rs6755814; rs7564761; rs7577421

# Metabolic_Enzyme_2_General_References:
1549570; 8088791; 1339255; 8507202; 8507203; 10671565; 2039509; 1697032

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5532

# Metabolic_Enzyme_3_Name:
Aldehyde dehydrogenase X, mitochondrial precursor

# Metabolic_Enzyme_3_Synonyms:
Aldehyde dehydrogenase family 1 member B1; ALDH class 2

# Metabolic_Enzyme_3_Gene_Name:
ALDH1B1

# Metabolic_Enzyme_3_Protein_Sequence:
>Aldehyde dehydrogenase X, mitochondrial precursor
MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT
TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNLLADLVERDRVYLA
SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCG
QIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITG
YGPTAGAAIAQHMDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADM
EHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGP
QVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP
VQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHT
PFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS

# Metabolic_Enzyme_3_Number_of_Residues:
517

# Metabolic_Enzyme_3_Molecular_Weight:
57239

# Metabolic_Enzyme_3_Theoretical_pI:
6.79

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation

# Metabolic_Enzyme_3_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_3_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_3_Signals:
1-22

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1263008

# Metabolic_Enzyme_3_SwissProt_ID:
AL1B1_HUMAN (P30837)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ALDH1B1

# Metabolic_Enzyme_3_Geneatlas_id:
ALDH1B1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:407

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_3_Gene_Sequence:
>1554 bp
ATGCTGCGCTTCCTGGCACCCCGGCTGCTTAGCCTCCAGGGCAGGACCGCCCTCTACTCC
TCGGCAGCAGCCCTCCCAAGCCCCATTCTGAACCCAGACATCCCCTACAACCAGCTGTTC
ATCAACAATGAATGGCAAGATGCAGTCAGCAAGAAGACCTTCCCGACGGTCAACCCTACC
ACCGGGGAGGTCATCGGGCACGTGGCTGAAGGTGACCGGGCTGATGTGGATCGGGCCGTG
AAAGCAGCCCGGGAAGCCTTCCGCCTGGGGTCCCCATGGCGCCGGATGGATGCCTCTGAG
CGGGGCCGGCTGCTGAACCTCCTGGCAGACCTAGTGGAGCGGGATCGAGTCTACTTGGCC
TCACTCGAGACCTTGGACAATGGGAAGCCTTTCCAAGAGTCTTACGCCTTGGACTTGGAT
GAGGTCATCAAGGTGTATCGGTACTTTGCTGGCTGGGCTGACAAGTGGCATGGCAAGACC
ATCCCCATGCATGGCCAGCATTTCTGCTTCACCCGGCATGAGCCCGTTGGTGTCTGTGGC
CAGATCATCCCGTGGAACTTCCCCTTGGTCATGCAGGGTTGGAAACTTGCCCCGGCACTC
GCCACAGGCAACACTGTGGTTATGAAGGTGGCAGAGCAGACCCCCCTCTCTGCCCTGTAT
TTGGCCTCCCTCATCAAGGAGGCAGGCTTTCCCCCTGGGGTGGTGAACATCATCACGGGG
TATGGCCCAACAGCAGGTGCGGCCATCGCCCAGCACATGGATGTTGACAAAGTTGCCTTC
ACCGGTTCCACCGAGGTGGGCCACCTGATCCAGAAAGCAGCTGGCGATTCCAACCTCAAG
AGAGTCACCCTGGAGCTGGGTGGTAAGAGCCCCAGCATCGTGCTGGCCGATGCTGACATG
GAGCATGCCGTGGAGCAGTGCCACGAAGCCCTGTTCTTCAACATGGGCCAGTGCTGCTGT
GCTGGCTCCCGGACCTTCGTGGAAGAATCCATCTACAATGAGTTTCTCGAGAGAACCGTG
GAGAAAGCAAAGCAGAGGAAAGTGGGGAACCCCTTTGAGCTGGACACCCAGCAGGGGCCT
CAGGTGGACAAGGAGCAGTTTGAACGAGTCCTAGGCTACATCCAGCTTGGCCAGAAGGAG
GGCGCAAAACTCCTCTGTGGCGGAGAGCGTTTCGGGGAGCGTGGTTTCTTCATCAAGCCT
ACTGTCTTTGGTGGCGTGCAGGATGACATGAGAATTGCCAAAGAGGAGATCTTTGGGCCT
GTGCAGCCCCTGTTCAAGTTCAAGAAGATTGAGGAGGTGGTTGAGAGGGCCAACAACACC
AGGTATGGCCTGGCTGCGGCTGTGTTCACCCGGGATCTGGACAAGGCCATGTACTTCACC
CAGGCACTCCAGGCCGGGACCGTGTGGGTAAACACCTACAACATCGTCACCTGCCACACG
CCATTTGGAGGGTTTAAGGAATCTGGAAACGGGAGGGAGCTGGGTGAGGATGGGCTTAAG
GCCTACACAGAGGTAAAGACGGTCACCATCAAGGTTCCTCAGAAGAACTCGTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M63967

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_3_Locus:
9p11.1

# Metabolic_Enzyme_3_SNPs:
rs2228093; rs4878199; rs2073478; rs2073477; rs2228094; rs3043; rs6476701; rs10758494; rs10758495; rs7859877; rs4646772; rs4646774; rs4878802; rs10738997; rs11555705; rs4646773; rs41278335; rs11555706; rs10973781; rs10973782; rs12343271; rs41278337; rs10118683; rs10758496; rs10814687; rs10973774; rs10973779; rs10973783; rs10973785; rs10973786; rs10973787; rs10973789; rs10973792; rs11361; rs11790480; rs11791018; rs11791622; rs12001093; rs12336048; rs12352007; rs12378762; rs13285234; rs13290293; rs1555480; rs1923423; rs1923424; rs2038589; rs34183602; rs35950473; rs4142260; rs4242647; rs4878203; rs4878800; rs4878801; rs4878804; rs4878805; rs4878806; rs4878807; rs4878808; rs4878809; rs4878811; rs6476703; rs7021469; rs7031628; rs7045542; rs7046137; rs7853954; rs7865905; rs7866277; rs7867383; rs911757; rs911758

# Metabolic_Enzyme_3_General_References:
2061311; 8244338

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5713

# Metabolic_Enzyme_4_Name:
Beta-Ala-His dipeptidase precursor

# Metabolic_Enzyme_4_Synonyms:
Carnosine dipeptidase 1; CNDP dipeptidase 1; Serum carnosinase; Glutamate carboxypeptidase-like protein 2

# Metabolic_Enzyme_4_Gene_Name:
CNDP1

# Metabolic_Enzyme_4_Protein_Sequence:
>BetaAlaHis dipeptidase precursor
MDPKLGRMAASLLAVLLLLLERGMFSSPSPPPALLEKVFQYIDLHQDEFVQTLKEWVAIE
SDSVQPVPRFRQELFRMMAVAADTLQRLGARVASVDMGPQQLPDGQSLPIPPVILAELGS
DPTKGTVCFYGHLDVQPADRGDGWLTDPYVLTEVDGKLYGRGATDNKGPVLAWINAVSAF
RALEQDLPVNIKFIIEGMEEAGSVALEELVEKEKDRFFSGVDYIVISDNLWISQRKPAIT
YGTRGNSYFMVEVKCRDQDFHSGTFGGILHEPMADLVALLGSLVDSSGHILVPGIYDEVV
PLTEEEINTYKAIHLDLEEYRNSSRVEKFLFDTKEEILMHLWRYPSLSIHGIEGAFDEPG
TKTVIPGRVIGKFSIRLVPHMNVSAVEKQVTRHLEDVFSKRNSSNKMVVSMTLGLHPWIA
NIDDTQYLAAKRAIRTVFGTEPDMIRDGSTIPIAKMFQEIVHKSVVLIPLGAVDDGEHSQ
NEKINRWNYIEGTKLFAAFFLEMAQLH

# Metabolic_Enzyme_4_Number_of_Residues:
507

# Metabolic_Enzyme_4_Molecular_Weight:
56693

# Metabolic_Enzyme_4_Theoretical_pI:
4.95

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  protein dimerization activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  metallopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_4_Pathway:
map00340  Histidine metabolism;
 map00410  beta-Alanine metabolism

# Metabolic_Enzyme_4_Reaction:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF07687:M20_dimer;
PF01546:Peptidase_M20

# Metabolic_Enzyme_4_Signals:
1-26

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.4.13.20

# Metabolic_Enzyme_4_GenBank_ID_Protein:
16555792

# Metabolic_Enzyme_4_SwissProt_ID:
CNDP1_HUMAN (Q96KN2)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CNDP1

# Metabolic_Enzyme_4_Geneatlas_id:
CNDP1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:20675

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_4_Gene_Sequence:
>1527 bp
ATGGATCCCAAACTCGGGAGAATGGCTGCGTCCCTGCTGGCTGTGCTGCTGCTGCTGCTG
CTGGAGCGCGGCATGTTCTCCTCACCCTCCCCGCCCCCGGCGCTGTTAGAGAAAGTCTTC
CAGTACATTGACCTCCATCAGGATGAATTTGTGCAGACGCTGAAGGAGTGGGTGGCCATC
GAGAGCGACTCTGTCCAGCCTGTGCCTCGCTTCAGACAAGAGCTCTTCAGAATGATGGCC
GTGGCTGCGGACACGCTGCAGCGCCTGGGGGCCCGTGTGGCCTCGGTGGACATGGGTCCT
CAGCAGCTGCCCGATGGTCAGAGTCTTCCAATACCTCCCGTCATCCTGGCCGAACTGGGG
AGCGATCCCACGAAAGGCACCGTGTGCTTCTACGGCCACTTGGACGTGCAGCCTGCTGAC
CGGGGCGATGGGTGGCTCACGGACCCCTATGTGCTGACGGAGGTAGGCGGGAAACTTTAT
GGACGAGGAGCGACCGACAACAAAGGCCCTGTCTTGGCTTGGATCAATGCTGTGAGCGCC
TTCAGAGCCCTGGAGCAAGATCTTCCTGTGAATATCAAATTCATCATTGAGGGGATGGAA
GAGGCTGGCTCTGTTGCCCTGGAGGAACTTGTGGAAAAAGAAAAGGACCGATTCTTCTCT
GGTGTGGACTACATTGTAATTTCAGATAACCTGTGGATCAGCCAAAGGAAGCTAGCAATC
ACTTACGGAACCCGGGGGAACAGCTACTTCATGGTGGAGGTGAAATGCAGAGACCAGGAT
TTTCACTCAGGAACCTTTGGTGGCATCCTTCATGAACTAATGGCTGATCTGGTTGCTCTT
CTCGGTAGCCTGGTAGACTCGTCTGGTCATATCCTGGTCCCTGGAATCTATGATGAAGTG
GTTCCTCTTACAGAAGAGGAAATAAATACATACAAAGCCATCCATCTAGACCTAGAAGAA
TACCGGAATAGCAGCCGGGTTGAGAAATTTCTGTTCGATACTAAGGAGGAGATTCTAATG
CACCTCTGGAGGTACCCATCTCTTTCTATTCATGGGATCGAGGGCGCGTTTGATGAGCCT
GGAACTAAAACAGTCATACCTGGCCGAGTTATAGGAAAATTTTCAATCCGTCTAGTCCCT
CACATGAATGTGTCTGCGGTGGAAAAACAGGTGACACGACATCTTGAAGATGTGTTCTCC
AAAAGAAATAGTTCCAACAAGATGGTTGTTTCCATGACTCTAGGACTACACCCGTGGATT
GCAAATATTGATGACACTCAGTATCTCGCAGCAAAAAGAGCGATCAGAACAGTGTTTGGA
ACAGAACCAGATATGATCCGGGATGGATCCACCATTCCAATTGCCAAAATGTTCCAGGAG
ATCGTCCACAAGAGCGTGGTGCTAATTCCGCTGGGAGCTGTTGATGATGGAGAACATTCG
CAGAATGAGAAAATCAACAGGTGGAACTACATAGAGGGAACCAAATTATTTGCTGCCTTT
TTCTTAGAGATGGCCCAGCTCCATTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AJ417564

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:18

# Metabolic_Enzyme_4_Locus:
18q22.3

# Metabolic_Enzyme_4_SNPs:
rs4263028; rs11151964; rs9807352; rs12960862; rs2887; rs4891564; rs2346064; rs1004453; rs7239132; rs12604675; rs10469123; rs10469203; rs12607796; rs12605490; rs8087768; rs9319909; rs4892246; rs7506171; rs4329999; rs7242384; rs8085167; rs11876996; rs7244370; rs7506929; rs4892243; rs7231312; rs4892242; rs12605520; rs733686; rs9967490; rs7229005; rs7232853; rs1426256; rs7506957; rs17817095; rs11875756; rs7506825; rs17817180; rs12961730; rs12964027; rs12456406; rs12964208; rs7506760; rs12956997; rs12456388; rs12964454; rs11873844; rs17817345; rs7505047; rs17089382; rs17089414; rs17089390; rs7233066; rs9953129; rs9960024; rs11659237; rs9807248; rs11662276; rs17816861; rs11873901; rs10469124; rs17089403; rs1559809; rs17817077; rs9949100; rs4891563; rs11661606; rs2881289; rs7228575; rs9957229; rs9955944; rs17089375; rs4892244; rs17089411; rs4892239; rs17238585; rs7505555; rs12326826; rs9946796; rs11876764; rs9949990; rs34570315; rs12957330; rs7506936; rs4892241; rs7506258; rs9952652; rs4355018; rs9957885; rs11664748; rs4133234; rs17238285; rs1974965; rs11659364; rs4892238; rs11875122; rs7237549; rs9948919; rs12959707; rs12457983; rs12964810; rs1974963; rs4891562; rs11873542; rs12962343; rs2881288; rs17089378; rs12954161; rs9959794; rs7504932; rs12327522; rs11664535; rs7230673; rs12455650; rs1974964; rs7244647; rs9989559; rs11875810; rs12954438; rs2098910; rs2346061; rs2346063; rs890333; rs2346062; rs2081548; rs890332; rs11538620; rs34522443; rs11538622; rs11538624; rs11538623; rs35604255; rs10533212; rs35771415; rs34713611; rs9967349; rs33922160; rs34365714; rs34526667; rs11875787; rs28448542; rs28871039; rs35084313; rs10549931; rs10685765; rs34874693; rs4891561; rs12606902; rs34117300; rs12959038; rs36228963; rs5826336; rs35735348; rs34499247; rs35885130; rs35388041; rs28713380; rs11151965; rs34138697; rs35204551; rs9966983; rs7505007; rs35096494; rs33950634; rs33981863; rs34142328; rs12959706; rs9955580; rs9947243; rs34869467; rs35788286; rs10624462; rs34283867; rs6566813; rs34962477; rs34335073; rs5826332; rs36060345; rs34573470; rs35682790; rs35362460; rs35860275; rs35365788; rs12964034; rs10522670; rs12959748; rs4892245; rs36111704; rs12969794; rs5826335; rs4891560; rs9965945; rs34070364; rs10624665; rs5826334; rs34842524; rs35877440; rs34785330; rs17089373; rs7233122; rs10596720; rs9948674; rs34189472; rs10562152; rs10649703; rs34321505; rs35707511; rs9949211; rs35368997; rs35691581; rs35734110; rs9953867; rs34563384; rs35469246; rs8087111; rs34726849; rs35932028; rs12969795; rs12969769; rs34799288; rs35234907; rs28800835; rs34646410; rs10685766; rs34895018; rs35597919; rs12961586; rs6566814; rs28877095; rs4892240; rs33911381; rs8088199; rs11872770; rs36206459; rs7350982; rs34145828; rs11447097; rs12104001; rs4892247; rs3080879; rs10663835; rs10871736; rs10871737; rs1130046; rs11664131; rs12327049; rs12456405; rs12954579; rs12966495; rs12967519; rs12970020; rs17089369; rs2114228; rs28534519; rs35248661; rs4353545; rs4891565; rs4891566; rs4892233; rs4892248; rs4892249; rs6566815; rs7238101; rs7504377; rs7506051; rs7506112; rs8096427; rs8099458; rs9319908

# Metabolic_Enzyme_4_General_References:
12975309

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5815

# Metabolic_Enzyme_5_Name:
Beta-ureidopropionase

# Metabolic_Enzyme_5_Synonyms:
Beta-alanine synthase; N- carbamoyl-beta-alanine amidohydrolase; BUP-1

# Metabolic_Enzyme_5_Gene_Name:
UPB1

# Metabolic_Enzyme_5_Protein_Sequence:
>Betaureidopropionase
MAGAEWKSLEECLEKHLPLPDLQEVKRVLYGKELRKLDLPREAFEAASREDFELQGYAFE
AAEEQLRRPR
IVHVGLVQNRIPLPANAPVAEQVSALHRRIKAIVEVAAMCGVNIICFQE
AWTMPFAFCTREKLPWTEFAE
SAEDGPTTRFCQKLAKNHDMVVVSPILERDSEHGDVLW
NTAVVISNSGAVLGKTRKNHIPRVGDFNESTY
YMEGNLGHPVFQTQFGRIAVNICYGRH
HPLNWLMYSINGAEIIFNPSATIGALSESLWPIEARNAAIANH
CFTCAINRVGTEHFPN
EFTSGDGKKAHQDFGYFYGSSYVAAPDSSRTPGLSRSRDGLLVAKLDLNLCQQV
NDVWN
FKMTGRYEMYARELAEAVKSNYSPTIVKE

# Metabolic_Enzyme_5_Number_of_Residues:
384

# Metabolic_Enzyme_5_Molecular_Weight:
43166

# Metabolic_Enzyme_5_Theoretical_pI:
6.51

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  nitrogen compound metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Converts N-carbamyl-beta-aminoisobutyric acid and N- carbamyl-beta-alanine to, respectively, beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide

# Metabolic_Enzyme_5_Pathway:
map00240  Pyrimidine metabolism;
 map00410  beta-Alanine metabolism;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_5_Reaction:
N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00795:CN_hydrolase

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.5.1.6

# Metabolic_Enzyme_5_GenBank_ID_Protein:
6288771

# Metabolic_Enzyme_5_SwissProt_ID:
BUP1_HUMAN (Q9UBR1)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
UPB1

# Metabolic_Enzyme_5_Geneatlas_id:
UPB1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:16297

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1155 bp

ATGGCGGGCGCTGAGTGGAAGTCGCTGGAGGAATGCTTGGAGAAGCACCTGCCGCTCCC
CGACTTGCAGG
AAGTGAAGCGCGTTCTCTATGGCAAGGAACTCAGGAAGCTTGATCTGC
CCAGGGAAGCTTTCGAAGCTGC
CTCCAGAGAAGACTTTGAACTGCAGGGATATGCCTTT
GAAGCAGCGGAGGAGCAGCTGAGACGACCCCGC
ATTGTGCACGTGGGGCTGGTTCAGAA
CAGAATCCCCCTCCCCGCAAATGCCCCTGTGGCAGAACAGGTCT
CTGCCCTTCATAGAC
GCATAAAGGCTATCGTAGAGGTGGCTGCAATGTGTGGAGTCAACATCATCTGTTT
CCAG
GAAGCATGGACTATGCCCTTTGCCTTCTGTACGAGAGAGAAGCTTCCTTGGACAGAATTT
GCTGAG
TCAGCAGAGGATGGGCCCACCACCAGATTCTGTCAGAAGCTGGCGAAGAACCA
TGACATGGTGGTGGTGT
CTCCCATCCTGGAACGAGACAGCGAGCATGGGGATGTTTTGT
GGAATACAGCCGTGGTGATCTCCAATTC
CGGAGCAGTCCTGGGAAAGACCAGGAAAAAC
CACATCCCCAGAGTGGGTGATTTCAACGAGTCAACTTAC
TACATGGAGGGAAACCTGGG
CCACCCCGTGTTCCAGACGCAGTTCGGAAGGATCGCGGTGAACATTTGCT
ACGGGCGGC
ACCACCCCCTCAACTGGCTTATGTACAGCATCAACGGGGCTGAGATCATCTTCAACCCCT
C
GGCCACGATAGGAGCACTCAGCGAGTCCCTGTGGCCCATCGAGGCCAGAAACGCAGCC
ATTGCCAATCAC
TGCTTCACCTGCGCCATCAATCGAGTGGGCACCGAGCACTTCCCGAA
CGAGTTTACCTCGGGAGATGGAA
AGAAAGCTCACCAGGACTTTGGCTACTTTTATGGCT
CGAGCTATGTGGCAGCCCCTGACAGCAGCCGGAC
TCCTGGGCTGTCCCGTAGCCGGGAT
GGACTGCTAGTTGCTAAGCTCGACCTAAACCTCTGCCAGCAGGTG
AATGATGTCTGGAA
CTTCAAGATGACGGGCAGGTATGAGATGTACGCACGGGAGCTCGCCGAAGCTGTCA
AGT
CCAACTACAGCCCCACCATCGTGAAAGAGTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AF163312

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_5_Locus:
22q11.2

# Metabolic_Enzyme_5_SNPs:
rs34110964; rs2232867; rs1314; rs2070474; rs2232866; rs140330; rs6004171; rs1892721; rs2232868; rs738814; rs1015011; rs140324; rs5760464; rs140338; rs6004175; rs5996713; rs762279; rs8142051; rs140335; rs3788372; rs12159862; rs3788369; rs140337; rs131455; rs2298384; rs5760455; rs131456; rs1015050; rs12628029; rs6004167; rs5760467; rs175766; rs5996712; rs140334; rs4414772; rs35270298; rs2298385; rs3788370; rs5751894; rs9612646; rs3788371; rs8141985; rs5751893; rs140331; rs8139394; rs11912222; rs5760466; rs7290860; rs5760459; rs11704820; rs16978612; rs140332; rs2232865; rs6004174; rs5751892; rs7289159; rs2070473; rs34035085; rs9620392; rs2232870; rs35916595; rs2070475; rs34595756; rs33939150; rs6004176; rs175767; rs9608293; rs13055831; rs5760465; rs5760457; rs34272823; rs34212925; rs11704528; rs140339; rs5760461; rs5751891; rs9620394; rs34817009; rs35770800; rs5760458; rs5844593; rs9624489; rs131454; rs10428056; rs10427702; rs6004172; rs5760460; rs7290073; rs140326; rs12170801; rs41446544; rs11306738; rs8139687; rs35821245; rs140329; rs11912437; rs11704936; rs28588566; rs9612641; rs12159402; rs9624487; rs5751890; rs5996709; rs28793636; rs35606558; rs34346301; rs5760463; rs12168497; rs35350082; rs6004168; rs140327; rs5996711; rs34804666; rs12166299; rs140325; rs13056366; rs12170842; rs140328; rs131452; rs6004173; rs8137394; rs9624485; rs9624488; rs34688005; rs9624486; rs9612637; rs12159199; rs9608291; rs140333; rs10427760; rs5996710; rs12169955; rs2232864; rs6004169; rs3765615; rs11350644; rs140336; rs3032747; rs34577100; rs13056367; rs9624484; rs6004170; rs2232869; rs9612640; rs28461476; rs7289603; rs5760462; rs131453; rs4049935; rs34276962; rs5760456; rs11913979; rs9612643; rs34916208; rs34067128; rs41302573; rs2232863; rs2232862; rs2232858; rs2232860; rs5751889; rs7289016; rs2232861; rs2232859; rs2232857; rs11090327; rs131460; rs140342; rs1543757; rs17004940; rs4346492; rs4558681; rs4820592; rs4822501; rs4822502; rs5760449; rs5760450; rs5760451; rs5760452; rs5760469; rs5996707; rs5996715; rs9612648

# Metabolic_Enzyme_5_General_References:
10542323; 11508704

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5530

# Metabolic_Enzyme_6_Name:
Aldehyde dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_6_Synonyms:
ALDH class 2; ALDHI; ALDH-E2

# Metabolic_Enzyme_6_Gene_Name:
ALDH2

# Metabolic_Enzyme_6_Protein_Sequence:
>Aldehyde dehydrogenase, mitochondrial precursor
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS

# Metabolic_Enzyme_6_Number_of_Residues:
517

# Metabolic_Enzyme_6_Molecular_Weight:
56382

# Metabolic_Enzyme_6_Theoretical_pI:
7.05

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_6_Specific_Function:
An aldehyde + NAD(+) + H(2)O = an acid + NADH

# Metabolic_Enzyme_6_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_6_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_6_Signals:
1-24

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_6_GenBank_ID_Protein:
28606

# Metabolic_Enzyme_6_SwissProt_ID:
ALDH2_HUMAN (P05091)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ALDH2

# Metabolic_Enzyme_6_Geneatlas_id:
ALDH2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:404

# Metabolic_Enzyme_6_PDB_ID:
1OF7

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_6_Gene_Sequence:
>1551 bp
ATGTTGCGCGCTGCCGCCGCTCGGGCCCCGCCTGGCCGCCGCCTCTTGTCAGCCGCCGCC
ACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTTCATA
AACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACT
GGAGAGGTCATCTGTCAGGTAGCTGAAGGGGACAAGGAAGATGTGGACAAGGCACGTGAA
GGCCGCCCGGGCGCCTTCCAGCTGGGCTCACCTTGGCGCCGCATGGACGCATCACACAGC
GGCCGGCTGCTGAACCGCCTGGCCGATCTGATCGAGCGGGACCGGACCTACCTGGCGGCC
TTGGAGACCCTGGACAATGGCAAGCCCTATGTCATCTCCTACCTGGTGGATTTGGACATG
GTCCTCAAATGTCTCCGGTATTATGCCGGCTGGGCTGATAAGTACCACGGGAAAACCATC
CCCATTGACGGAGACTTCTTCAGCTACACACGCCATGAACCTGTGGGGGTGTGCGGGCAG
ATCATTCCGTGGAATTTCCCGCTCCTGATGCAAGCATGGAAGCTGGGCCCAGCCTTGGCA
ACTGGAAACGTGGTTGTGATGAAGGTAGCTGAGCAGACACCCCTCACCGCCCTCTATGTG
GCCAACCTGATCAAGGAGGCTGGCTTTCCCCCTGGTGTGGTCAACATTGTGCCTGGATTT
GGCCCCACGGCTGGGGCCGCCATTGCCTCCCATGAGGATGTGGACAAAGTGGCATTCACA
GGCTCCACTGAGATTGGCCGCGTAATCCAGGTTGCTGCTGGGAGCAGCAACCTCAAGAGA
GTGACCTTGGAGCTGGGGGGGAAGAGCCCCAACATCATCATGTCAGATGCCGATATGGAT
TGGGCCGTGGAACAGGCCCACTTCGCCCTGTTCTTCAACCAGGGCCAGTGCTGCTGTGCC
GGCTCCCGGACCTTCGTGCAGGAGGACATCTATGATGAGTTTGTGGTGCGGAGCGTTGCC
CGGGCCAAGTCTCGGGTGGTCGGGAACCCCTTTGATAGCAAGACCGAGCAGGGGCCGCAG
GTGGATGAAACTCAGTTTAAGAAGATCCTCGGCTACATCAACACGGGGAAGCAAGAGGGG
GCGAAGCTGCTGTGTGGTGGGGGCATTGCTGCTGACCGTGGTTACTTCATCCAGCCCACT
GTGTTTGGAGATGTGCAGGATGGCATGACCATCGCCAAGGAGGAGATCTTCGGGCCAGTG
ATGCAGATCCTGAAGTTCAAGACCATAGAGGAGGTTGTTGGGAGAGCCAACAATTCCACG
TACGGGCTGGCCGCAGCTGTCTTCACAAAGGATTTGGACAAGGCCAATTACCTGTCCCAG
GCCCTCCAGGCGGGCACTGTGTGGGTCAACTGCTATGATGTGTTTGGAGCCCAGTCACCC
TTTGGTGGCTACAAGATGTCGGGGAGTGGCCGGGAGTTGGGCGAGTACGGGCTGCAGGCA
TACACTGAAGTGAAAACTGTCACAGTCAAAGTGCCTCAGAAGAACTCATAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
X05409

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_6_Locus:
12q24.2

# Metabolic_Enzyme_6_SNPs:
rs671; rs1062136; rs6490301; rs886205; rs2238151; rs968529; rs7296651; rs441; rs4767939; rs10744777; rs4646778; rs4767944; rs10849970; rs2158029; rs4646776; rs7312055; rs7311852; rs2238152; rs4646777; rs2283354; rs10774637; rs4648328; rs10774638; rs11609628; rs11066028; rs4646779; rs16941669; rs440; rs7397491; rs11834780; rs16941667; rs4646775; rs11066029; rs35154896; rs11066024; rs2106696; rs11613231; rs2158028; rs4767035; rs13306166; rs34083959; rs7136890; rs13306164; rs1064933; rs34477327; rs34884061; rs28633753; rs11442381; rs11615695; rs11066023; rs35511855; rs35781311; rs13306163; rs7397456; rs35050853; rs35642129; rs12312867; rs12829533; rs11407827; rs34480430; rs12314397; rs35264878; rs12813835; rs12322000; rs34896918; rs35650885; rs7970477; rs11066025; rs13306167; rs11066027; rs12301347; rs11614684; rs35700215; rs35746295; rs34587287; rs13306165; rs35786282; rs11066022; rs7397469; rs11066030; rs10450717; rs35693865; rs11503169; rs35546929; rs33973376; rs34497874; rs12830829; rs35061167; rs11609093; rs36073646; rs34108639; rs12824249; rs11610258; rs35147079; rs11613713; rs11066026; rs7486832; rs12099590; rs3832868; rs34300515; rs35212101; rs7398472; rs35239056; rs35752199; rs5800933; rs11613351; rs5023470; rs34587619; rs4646781; rs4646780; rs11304348; rs12305979; rs4646782; rs10849969; rs10849971; rs11066032; rs14630; rs2339839; rs2339840; rs7133964; rs737280; rs739580; rs7974339; rs7978737; rs9971942

# Metabolic_Enzyme_6_General_References:
3582651; 3562250; 2838413; 4065146; 2987944; 4015823; 3610592; 3653404; 6582480; 8561277; 10631996

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5531

# Metabolic_Enzyme_7_Name:
Fatty aldehyde dehydrogenase

# Metabolic_Enzyme_7_Synonyms:
Aldehyde dehydrogenase, microsomal; Aldehyde dehydrogenase family 3 member A2; Aldehyde dehydrogenase 10

# Metabolic_Enzyme_7_Gene_Name:
ALDH3A2

# Metabolic_Enzyme_7_Protein_Sequence:
>Fatty aldehyde dehydrogenase
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE
VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ
PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH
IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT
CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI
AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA
LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS
HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV
KAEYY

# Metabolic_Enzyme_7_Number_of_Residues:
485

# Metabolic_Enzyme_7_Molecular_Weight:
54849

# Metabolic_Enzyme_7_Theoretical_pI:
7.99

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_7_Specific_Function:
Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length

# Metabolic_Enzyme_7_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_7_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
464-480

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_7_GenBank_ID_Protein:
1082036

# Metabolic_Enzyme_7_SwissProt_ID:
AL3A2_HUMAN (P51648)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
ALDH3A2

# Metabolic_Enzyme_7_Geneatlas_id:
ALDH3A2

# Metabolic_Enzyme_7_hgnc_id:
HGNC:403

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein; cytoplasmic side

# Metabolic_Enzyme_7_Gene_Sequence:
>1458 bp
ATGGAGCTCGAAGTCCGGCGGGTCCGACAGGCGTTCCTGTCCGGCCGGTCGCGACCTCTG
CGGTTTCGGCTGCAGCAGCTGGAGGCCCTGCGGAGGATGGTGCAGGAGCGCGAGAAGGAT
ATCCTGACGGCCATCGCCGCCGACCTGTGCAAGAGTGAATTCAATGTGTACAGTCAGGAA
GTCATTACTGTCCTTGGGGAAATTGATTTTATGCTTGAGAATCTTCCTGAATGGGTTACT
GCTAAACCAGTTAAGAAGAACGTGCTCACCATGCTGGATGAGGCCTATATTCAGCCACAG
CCTCTGGGAGTGGTGCTGATAATCGGAGCTTGGAATTACCCCTTCGTTCTCACCATTCAG
CCACTGATAGGAGCCATCGCTGCAGGAAATGCTGTGATTATAAAGCCTTCTGAACTGAGT
GAAAATACAGCCAAGATCTTGGCAAAGCTTCTCCCTCAGTATTTAGACCAGGATCTCTAT
ATTGTTATTAATGGTGGTGTTGAGGAAACCACGGAGCTCCTGAAGCAGCGATTTGACCAC
ATTTTCTATACGGGAAACACTGCGGTTGGCAAAATTGTCATGGAAGCTGCTGCCAAGCAT
CTGACCCCTGTGACTCTTGAACTGGGAGGGAAAAGTCCATGTTATATTGATAAAGATTGT
GACCTGGACATTGTTTGCAGACGCATAACCTGGGGAAAATACATGAATTGTGGCCAAACC
TGCATTGCACCCGACTATATTCTCTGTGAAGCATCCCTCCAAAATCAAATTGTATGGAAG
ATTAAGGAAACAGTGAAGGAATTTTATGGAGAAAATATAAAAGAGTCTCCTGATTATGAA
AGGATCATCAATCTTCGTCATTTTAAGAGGATACTAAGTTTGCTTGAAGGACAAAAGATA
GCTTTTGGTGGGGAGACTGATGAGGCCACACGCTACATAGCCCCAACAGTACTTACCGAT
GTTGATCCTAAAACCAAGGTGATGCAAGAAGAAATTTTTGGACCAATTCTTCCAATAGTG
CCTGTGAAAAATGTAGATGAGGCCATAAATTTCATAAATGAACGTGAAAAGCCTCTGGCT
CTTTATGTATTTTCGCATAACCATAAGCTCATCAAACGGATGATTGATGAGACATCCAGT
GGAGGTGTCACAGGCAATGACGTCATTATGCACTTCACGCTCAACTCTTTCCCATTTGGA
GGAGTGGGTTCCAGTGGGATGGGAGCTTATCACGGAAAACATAGTTTTGATACTTTTTCT
CATCAGCGTCCCTGTTTATTAAAAAGTTTAAAGAGAGAAGGTGCTAACAAACTCAGATAT
CCTCCCAACAGCCAGTCAAAGGTGGATTGGGGGAAATTTTTTCTCTTGAAACGGTTCAAC
AAAGAAAAACTCGGTCTCCTGTTGCTCACTTTCCTGGGTATTGTAGCCGCTGTGCTTGTC
AAGGCAGAATATTACTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
L47162

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_7_Locus:
17p11.2

# Metabolic_Enzyme_7_SNPs:
rs7216; rs7503517; rs7215; rs16420; rs11204408; rs3786038; rs962801; rs2072333; rs1034897; rs2072331; rs2108971; rs1004490; rs1004491; rs4244600; rs962800; rs8069576; rs4925036; rs2072332; rs16960280; rs4646797; rs8069478; rs2386145; rs1800869; rs11204407; rs4646798; rs4646794; rs4925038; rs4646800; rs4925037; rs4646795; rs4646804; rs4646802; rs8073767; rs12937946; rs9910300; rs4646801; rs9901895; rs1034896; rs3760489; rs4621031; rs3888642; rs1057405; rs11548343; rs12947169; rs34160909; rs35364675; rs7209322; rs35495378; rs12947168; rs12708; rs4646805; rs7215552; rs35965955; rs2386146; rs35716578; rs34082599; rs4646799; rs4646796; rs3034928; rs1800870; rs35581449; rs5819686; rs34567842; rs34350257; rs34642385; rs4646793; rs11652177; rs4646907; rs34471504; rs8073053; rs2386147; rs6146012; rs34945824; rs36031953; rs34327718; rs35797108; rs34664206; rs4646803; rs35265843; rs36025724; rs35053333; rs3841513; rs34368630; rs4646806; rs35604266; rs16960266; rs28375263; rs11868363; rs11871420; rs11871642; rs12937179; rs1804608; rs2386144; rs34399035; rs34416664; rs35526408; rs4646807; rs4925026; rs8065688; rs8074204; rs8074500

# Metabolic_Enzyme_7_General_References:
8528251; 9027499; 9070922; 9254849; 9829906

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5526

# Metabolic_Enzyme_8_Name:
4-trimethylaminobutyraldehyde dehydrogenase

# Metabolic_Enzyme_8_Synonyms:
TMABADH; Aldehyde dehydrogenase 9A1; Aldehyde dehydrogenase E3 isozyme; Gamma-aminobutyraldehyde dehydrogenase; R- aminobutyraldehyde dehydrogenase

# Metabolic_Enzyme_8_Gene_Name:
ALDH9A1

# Metabolic_Enzyme_8_Protein_Sequence:
>4trimethylaminobutyraldehyde dehydrogenase
MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA
AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY
AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK
PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI
MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI
LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY
VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA
AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL
KTVCVEMGDVESAF

# Metabolic_Enzyme_8_Number_of_Residues:
494

# Metabolic_Enzyme_8_Molecular_Weight:
53802

# Metabolic_Enzyme_8_Theoretical_pI:
5.61

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_8_Specific_Function:
Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction

# Metabolic_Enzyme_8_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_8_Reaction:
4-trimethylammoniobutanal + NAD+ = 4-trimethylammoniobutanoate + NADH + H+

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.2.1.47;EC 1.2.1.3;EC

# Metabolic_Enzyme_8_GenBank_ID_Protein:
1049219

# Metabolic_Enzyme_8_SwissProt_ID:
AL9A1_HUMAN (P49189)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
ALDH9A1

# Metabolic_Enzyme_8_Geneatlas_id:
ALDH9A1

# Metabolic_Enzyme_8_hgnc_id:
HGNC:412

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_8_Gene_Sequence:
>1482 bp
ATGAGCACTGGCACCTTCGTCGTGTCGCAGCCGCTCAATTACCGCGGCGGGGCCGCTGGA
GCCGGCGGACGCTCCGGTACCGAGAAAGCTTTCGAGCCAGCAACCGGCCGAGTGATAGCT
ACTTTCACATGTTCAGGAGAAAAGGAAGTAAATTTGGCTGTTCAAAATGCAAAGGCTGCT
TTTAAAATATGGAGTCAAAAATCTGGCATGGAGCGTTGCCGAATCCTTTTGGAGGCTGCC
AGGATAATAAGGGAACGGGAGGATGAAATTGCTACTATGGAGTGCATCAACAATGGCAAG
TCCATCTTTGAGGCCCGCTTGGACATTGACATTTCCTGGCAGTGCCTGGAGTATTATGCG
GGCTTGGCTGCATCCATGGCTGGTGAACACATCCAGCTCCCAGGTGGATCGTTTGGTTAT
ACCAGAAGAGAACCACTTGGGGTATGTGTGGGAATAGGAGCATGGAACTACCCCTTTCAG
ATTGCCTCTTGGAAGTCGGCTCCAGCATTAGCCTGTGGTAATGCCATGGTCTTTAAACCT
TCTCCCTTTACACCTGTTTCTGCATTGCTACTGGCTGAAATCTACAGTGAGGCTGGTGTA
CCTCCTGGGCTCTTCAATGTGGTGCAGGGAGGGGCTGCCACAGGCCAGTTTCTGTGTCAG
CATCCCGATGTGGCCAAAGTCTCCTTCACTGGAAGTGTGCCCACTGGCATGAAGATCATG
GAGATGTCAGCTAAAGGAATCAAACCTGTTACCTTGGAACTTGGAGGCAAATCTCCACTC
ATCATCTTCTCAGACTGTGATATGAACAATGCTGTAAAGGGGGCGCTGATGGCCAACTTC
CTCACACAAGGCCAGGTTTGCTGTAATGGCACAAGAGTATTTGTGCAGAAAGAAATTCTT
GATAAATTTACAGAGGAAGTGGTGAAACAGACCCAAAGGATTAAAATTGGAGATCCCCTT
CTGGAAGATACAAGGATGGGTCCACTCATCAACCGACCACACCTGGAGCGAGTCCTTGGG
TTTGTCAAAGTGGCAAAGGAGCAGGGTGCTAAAGTGTTATGTGGTGGAGATATATATGTA
CCTGAAGATCCCAAATTAAAGGATGGATATTACATGAGACCTTGTGTATTAACTAATTGC
AGAGACGACATGACCTGTGTGAAGGAAGAGATCTTTGGGCCTGTTATGTCCATTTTATCA
TTTGACACTGAAGCTGAGGTTCTAGAAAGAGCCAATGATACCACTTTTGGACTAGCAGCT
GGCGTCTTTACCAGGGACATCCAACGGGCTCATAGAGTGGTAGCTGAGCTTCAGGCTGGG
ACGTGCTTCATTAACAACTATAACGTCAGCCCAGTGGAGTTGCCCTTTGGTGGATATAAG
AAGTCAGGATTTGGCAGAGAGAACGGCCGTGTGACAATCGAATATTATTCACAGCTGAAG
ACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
U34252

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_8_Locus:
1q23.1

# Metabolic_Enzyme_8_SNPs:
rs1065756; rs11808728; rs1143659; rs11506; rs12670; rs12408101; rs1913844; rs2882006; rs10753688; rs4646891; rs4646889; rs7516126; rs12565874; rs3820362; rs10800129; rs10800128; rs7534437; rs12072634; rs4656457; rs1337442; rs2348728; rs4578194; rs12080699; rs7541817; rs10918239; rs2348727; rs3738192; rs6683969; rs12065621; rs2348734; rs16849230; rs6426930; rs12083232; rs7513998; rs12122497; rs7555787; rs4646886; rs10800127; rs10918252; rs2348729; rs4646883; rs7518869; rs10800133; rs2176151; rs4646882; rs1538115; rs10800131; rs4646897; rs6690818; rs2050619; rs10753689; rs7546084; rs12076579; rs17482717; rs4657463; rs10918235; rs11587760; rs4274037; rs12567331; rs4557947; rs1337443; rs10800130; rs10800132; rs4646895; rs16849238; rs17450889; rs12033254; rs12069198; rs6657651; rs10918245; rs3845537; rs10918237; rs11807857; rs11807866; rs884121; rs4657462; rs10918236; rs7543204; rs2184918; rs12070650; rs17417191; rs9970857; rs6662419; rs7367737; rs10918242; rs10918241; rs7546322; rs4646888; rs16849374; rs12409168; rs12037790; rs10918247; rs7537071; rs12084748; rs10918238; rs7368130; rs2348730; rs10918244; rs4233407; rs12123278; rs4646892; rs4657466; rs4576644; rs6683651; rs6667075; rs12021795; rs6683665; rs12081464; rs7546215; rs7519162; rs10918240; rs6667088; rs6669697; rs12081903; rs4646885; rs7542184; rs16849479; rs4646887; rs12072664; rs10753687; rs4646896; rs10157944; rs6668102; rs3753893; rs4657468; rs3753892; rs7553712; rs7511691; rs7554409; rs7544840; rs6426928; rs6667681; rs4646881; rs1415503; rs11555775; rs9164; rs4646902; rs6667510; rs11555774; rs4307543; rs11436915; rs34948330; rs12139219; rs34495301; rs10918248; rs1890080; rs35894201; rs4646884; rs28759374; rs12137604; rs28589393; rs34662022; rs12354157; rs10918246; rs35087657; rs34105906; rs35913333; rs34664103; rs12083492; rs2271658; rs34872122; rs7512816; rs4646893; rs7527514; rs12566251; rs1970286; rs3831954; rs2348731; rs10918249; rs35178491; rs36027739; rs35864611; rs17416948; rs4646894; rs11583089; rs12742656; rs12754903; rs12742657; rs41267568; rs4646890; rs12084651; rs4646900; rs34304173; rs13376536; rs12727801; rs41326750; rs28439296; rs12134617; rs12036561; rs35531113; rs3845536; rs36011778; rs12090132; rs7525102; rs10918250; rs3738191; rs12239517; rs4646898; rs34072474; rs34945812; rs10918251; rs1890079; rs35439339; rs36150573; rs1577847; rs12728137; rs34846458; rs4646901; rs36110991; rs12083091; rs34894576; rs6426927; rs11458950; rs1856143; rs35757606; rs41267564; rs41267566; rs35742388; rs10494446; rs10494447; rs10800123; rs10800125; rs10800126; rs10800135; rs10800136; rs10918228; rs10918229; rs10918231; rs10918254; rs10918255; rs10918256; rs11579160; rs11800476; rs11810856; rs12027066; rs12028588; rs12043815; rs12044709; rs12060366; rs12143472; rs12748251; rs1547725; rs16848876; rs16848958; rs16849041; rs16849616; rs1878074; rs1878075; rs2090281; rs2297762; rs2297763; rs2297764; rs2297765; rs3753894; rs3795540; rs4147602; rs4147604; rs4147605; rs4147610; rs4147611; rs4341347; rs7527279; rs7549511; rs7551594; rs8133; rs9333483; rs9333487; rs9919190

# Metabolic_Enzyme_8_General_References:
8786138; 10702312; 8645224; 8269919; 2925663

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5527

# Metabolic_Enzyme_9_Name:
Aldehyde dehydrogenase, dimeric NADP-preferring

# Metabolic_Enzyme_9_Synonyms:
ALDH class 3; ALDHIII

# Metabolic_Enzyme_9_Gene_Name:
ALDH3A1

# Metabolic_Enzyme_9_Protein_Sequence:
>Aldehyde dehydrogenase, dimeric NADPpreferring
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH

# Metabolic_Enzyme_9_Number_of_Residues:
453

# Metabolic_Enzyme_9_Molecular_Weight:
50380

# Metabolic_Enzyme_9_Theoretical_pI:
6.52

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_9_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes

# Metabolic_Enzyme_9_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_9_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_9_GenBank_ID_Protein:
178402

# Metabolic_Enzyme_9_SwissProt_ID:
AL3A1_HUMAN (P30838)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
ALDH3A1

# Metabolic_Enzyme_9_Geneatlas_id:
ALDH3A1

# Metabolic_Enzyme_9_hgnc_id:
HGNC:405

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_9_Gene_Sequence:
>1362 bp
ATGAGCAAGATCAGCGAGGCCGTGAAGCGCGCCCGCGCCGCCTTCAGCTCGGGCAGGACC
CGTCCGCTGCAGTTCCGATTCCAGCAGCTGGAGGCGCTGCAGCGCCTGATCCAGGAGCAG
GAGCAGGAGCTGGTGGGCGCGCTGGCCGCAGACCTGCACAAGAATGAATGGAACGCCTAC
TATGAGGAGGTGGTGTACGTCCTAGAGGAGATCGAGTACATGATCCAGAAGCTCCCTGAG
TGGGCCGCGGATGAGCCCGTGGAGAAGACGCCCCAGACTCAGCAGGACGAGCTCTACATC
CACTCGGAGCCACTGGGCGTGGTCCTCGTCATTGGCACCTGGAACTACCCCTTCAACCTC
ACCATCCAGCCCATGGTGGGCGCCATCGCTGCAGGGAACGCAGTGGTCCTCAAGCCCTCG
GAGCTGAGTGAGAACATGGCGAGCCTGCTGGCTACCATCATCCCCCAGTACCTGGACAAG
GATCTGTACCCAGTAATCAATGGGGGTGTCCCTGAGACCACGGAGCTGCTCAAGGAGAGG
TTCGACCATATCCTGTACACGGGCAGCACGGGGGTGGGGAAGATCATCATGACGGCTGCT
GCCAAGCACCTGACCCCTGTCACGCTGGAGCTGGGAGGGAAGAGTCCCTGCTACGTGGAC
AAGAACTGTGACCTGGACGTGGCCTGCCGACGCATCGCCTGGGGGAAATTCATGAACAGT
GGCCAGACCTGCGTGGCCCCAGACTACATCCTCTGTGACCCCTCGATCCAGAACCAAATT
GTGGAGAAGCTCAAGAAGTCACTGAAAGAGTTCTACGGGGAAGATGCTAAGAAATCCCGG
GACTATGGAAGAATCATTAGTGCCCGGCACTTCCAGAGGGTGATGGGCCTGATTGAGGGC
CAGAAGGTGGCTTATGGGGGCACCGGGGATGCCGCCACTCGCTACATAGCCCCCACCATC
CTCACGGACGTGGACCCCCAGTCCCCGGTGATGCAAGAGGAGATCTTCGGGCCTGTGCTG
CCCATCGTGTGCGTGCGCAGCCTGGAGGAGGCCATCCAGTTCATCAACCAGCGTGAGAAG
CCCCTGGCCCTCTACATGTTCTCCAGCAACGACAAGGTGATTAAGAAGATGATTGCAGAG
ACATCCAGTGGTGGGGTGGCGGCCAACGATGTCATCGTCCACATCACCTTGCACTCTCTG
CCCTTCGGGGGCGTGGGGAACAGCGGCATGGGATCCTACCATGGCAAGAAGAGCTTCGAG
ACTTTCTCTCACCGCCGCTCTTGCCTGGTGAGGCCTCTGATGAATGATGAAGGCCTGAAG
GTCAGATACCCCCCGAGCCCGGCCAAGATGACCCAGCACTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
M74542

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_9_Locus:
17p11.2

# Metabolic_Enzyme_9_SNPs:
rs887241; rs2228100; rs3744692; rs2072330; rs4646787; rs1042183; rs917520; rs4646789; rs4646788; rs3786036; rs887240; rs2072329; rs4646790; rs3744693; rs9895030; rs3826507; rs3744695; rs3744694; rs2072328; rs1006556; rs4319825; rs1042172; rs11554977; rs11554978; rs11554975; rs11554974; rs34474118; rs3786037; rs35473971; rs4646792; rs35116940; rs4646791; rs35853488; rs887239; rs28531080; rs7216299; rs35009373; rs3786035; rs11385990; rs35308039; rs35128135; rs35885485; rs28552545; rs34438543; rs1006553; rs11650088; rs11651480; rs11870332; rs12948881; rs12949049; rs12951039; rs16960382; rs16960386; rs17793620; rs1989379; rs2016823; rs2052052; rs2072327; rs2108967; rs3760485; rs3760486; rs3760487; rs4646783; rs4646784; rs4646785; rs4646786; rs4924793; rs4925046; rs7214841; rs7221211; rs7225305; rs8075157; rs9898715; rs9900430

# Metabolic_Enzyme_9_General_References:
1737758; 8493892; 2037078; 9250352

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5528

# Metabolic_Enzyme_10_Name:
Alpha-aminoadipic semialdehyde dehydrogenase

# Metabolic_Enzyme_10_Synonyms:
Alpha-AASA dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenease; P6c dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1

# Metabolic_Enzyme_10_Gene_Name:
ALDH7A1

# Metabolic_Enzyme_10_Protein_Sequence:
>Alphaaminoadipic semialdehyde dehydrogenase
MSTLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADY
EETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQ
EYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIA
MICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVN
LLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQ
RCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEA
KKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWN
NEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRES
GSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ

# Metabolic_Enzyme_10_Number_of_Residues:
511

# Metabolic_Enzyme_10_Molecular_Weight:
55367

# Metabolic_Enzyme_10_Theoretical_pI:
6.86

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_10_Specific_Function:
L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H

# Metabolic_Enzyme_10_Pathway:
map00300  Lysine biosynthesis;
 map00310  Lysine degradation

# Metabolic_Enzyme_10_Reaction:
L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 1.2.1.31

# Metabolic_Enzyme_10_GenBank_ID_Protein:
797410

# Metabolic_Enzyme_10_SwissProt_ID:
AL7A1_HUMAN (P49419)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
ALDH7A1

# Metabolic_Enzyme_10_Geneatlas_id:
ALDH7A1

# Metabolic_Enzyme_10_hgnc_id:
HGNC:877

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Not Available

# Metabolic_Enzyme_10_Gene_Sequence:
>1536 bp
ATGTCCACTCTCCTCATCAATCAGCCCCAGTATGCGTGGCTGAAAGAGCTGGGGCTCCGC
GAGGAAAACGAGGGCGTGTATAATGGAAGCTGGGGAGGCCGGGGAGAGGTTATTACGACC
TATTGCCCCGCTAACAACGAGCCAATAGCAAGAGTCCGACAGGCCAGTGTGGCAGACTAT
GAAGAAACTGTAAAGAAAGCAAGAGAAGCATGGAAAATCTGGGCAGATATTCCTGCTCCA
AAACGAGGAGAAATAGTAAGACAGATTGGCGATGCCTTGCGGGAGAAGATCCAAGTACTA
GGAAGCTTGGTGTCTTTGGAGATGGGGAAAATCTTAGTGGAAGGTGTGGGTGAAGTTCAG
GAGTATGTGGATATCTGTGACTATGCTGTTGGTTTATCAAGGATGATTGGAGGACCTATC
TTGCCTTCTGAAAGATCTGGCCATGCACTGATTGAGCAGTGGAATCCCGTAGGCCTGGTT
GGAATCATCACGGCATTCAATTTCCCTGTGGCAGTGTATGGTTGGAACAACGCCATCGCC
ATGATCTGTGGAAATGTCTGCCTCTGGAAAGGAGCTCCAACCACTTCCCTCATTAGTGTG
GCTGTCACAAAGATAATAGCCAAGGTTCTGGAGGACAACAAGCTGCCTGGTGCAATTTGT
TCCTTGACTTGTGGTGGAGCAGATATTGGCACAGCAATGGCCAAAGATGAACGAGTGAAC
CTGCTGTCCTTCACTGGGAGCACTCAGGTGGGAAAACAGGTGGGCCTGATGGTGCAGGAG
AGGTTTGGGAGAAGTCTGTTGGAACTTGGAGGAAACAATGCCATTATTGCCTTTGAAGAT
GCAGACCTCAGCTTAGTTGTTCCATCAGCTCTCTTCGCTGCTGTGGGAACAGCTGGCCAG
AGGTGTACCACTGCGAGGCGACTGTTTATACATGAAAGCATCCATGATGAGGTTGTAAAC
AGACTTAAAAAGGCCTATGCACAGATCCGAGTTGGGAACCCATGGGACCCTAATGTTCTC
TATGGGCCACTCCACACCAAGCAGGCAGTGAGCATGTTTCTTGGAGCAGTGGAAGAAGCA
AAGAAAGAAGGTGGCACAGTGGTCTATGGGGGCAAGGTTATGGATCGCCCTGGAAATTAT
GTAGAACCGACAATTGTGACAGGTCTTGGCCACGATGCGTCCATTGCACACACAGAGACT
TTCGCTCCGATTCTCTATGTCTTTAAATTCAAGAATGAAGAAGAGGTCTTTGCATGGAAT
AATGAAGTAAAACAGGGACTTTCAAGTAGCATCTTTACCAAAGATCTGGGCAGAATCTTT
CGCTGGCTTGGACCTAAAGGATCAGACTGTGGCATTGTAAATGTCAACATTCCAACAAGT
GGGGCTGAGATTGGAGGTGCCTTTGGAGGAGAAAAGCACACTGGTGGTGGCAGGGAGTCT
GGCAGTGATGCCTGGAAACAGTACATGAGAAGGTCTACTTGTACTATCAACTACAGTAAA
GACCTTCCTCTGGCCCAAGGAATCAAGTTTCAGTAA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
S74728

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_10_Locus:
5q31

# Metabolic_Enzyme_10_SNPs:
rs12514417; rs2306618; rs2775; rs1038381; rs6595719; rs4835912; rs1038378; rs1038380; rs2306617; rs4379190; rs4836276; rs11241901; rs4240406; rs12513847; rs7709115; rs4836272; rs7713264; rs6870785; rs11241902; rs7714044; rs1038379; rs10050642; rs7723008; rs4836277; rs3734175; rs6898430; rs17154671; rs4626334; rs13182402; rs17154679; rs4835914; rs12653605; rs2306619; rs7719675; rs10478743; rs7700981; rs2035472; rs11241903; rs6861395; rs7724875; rs2291295; rs10519915; rs7719712; rs6898559; rs4626335; rs17154676; rs11952752; rs13179664; rs4835913; rs11742214; rs3734174; rs11742381; rs7736031; rs7737529; rs10478744; rs4836275; rs17154666; rs34241005; rs10043987; rs7718426; rs2013986; rs10067785; rs7719091; rs17165056; rs13188450; rs900645; rs7708281; rs7703958; rs7723494; rs10050872; rs7702811; rs13171814; rs6897789; rs13177576; rs7704283; rs4526102; rs11741551; rs10038571; rs4836273; rs3736174; rs3736171; rs1483780; rs900641; rs744722; rs900640; rs7718710; rs1060856; rs744720; rs17165061; rs744721; rs1807; rs6865317; rs6884473; rs7447092; rs3189320; rs1049217; rs1049211; rs11542969; rs1049214; rs11269202; rs6898845; rs35027610; rs35284915; rs34275373; rs35570062; rs34674137; rs28429591; rs7730016; rs4612066; rs36058537; rs2408702; rs11406545; rs1142071; rs13356526; rs35492150; rs34697893; rs10539406; rs34825424; rs7703752; rs12187161; rs34949719; rs36125577; rs36077292; rs7719949; rs35736560; rs34201518; rs33926729; rs34250591; rs13185811; rs34323751; rs34907915; rs28865092; rs35559498; rs35109136; rs10630162; rs4836274; rs34972014; rs13173864; rs7709981; rs6870070; rs2408703; rs35118533; rs10532390; rs34517958; rs34069611; rs10629966; rs7706009; rs34496788; rs34935903; rs35115612; rs13174679; rs10609859; rs34995966; rs34074703; rs36120385; rs34424711; rs34537297; rs7737783; rs35457522; rs35367836; rs36017518; rs17597559; rs7730933; rs33954485; rs35196030; rs35930104; rs34575294; rs10666972; rs10676689; rs35010266; rs34035179; rs28629815; rs7704352; rs35797169; rs10044223; rs35622239; rs35960414; rs34959052; rs35342756; rs13154789; rs4836278; rs35617751; rs34731336; rs12656014; rs34305021; rs34684581; rs5871220; rs11951146; rs35290920; rs13166319; rs2408633; rs11290126; rs34862437; rs35992646; rs35110442; rs10609860; rs11742868; rs6896807; rs17531712; rs34770295; rs3080835; rs11387172; rs7737256; rs34601459; rs9765047; rs1060857; rs3736172; rs11458774; rs1138001; rs7447380; rs5871218; rs1138005; rs34410568; rs3736173; rs35569843; rs744723; rs5871219; rs34450389; rs34135005; rs3830274; rs11750167; rs1384880; rs17154635; rs2035471; rs2128931; rs2306620; rs2306621; rs2306622; rs2408700; rs28365789; rs3734173; rs4240405; rs4597966; rs4835911; rs4836271; rs6882015; rs730870; rs7715516; rs7726892

# Metabolic_Enzyme_10_General_References:
8088832; 9417906

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5480

# Metabolic_Enzyme_11_Name:
4-aminobutyrate aminotransferase, mitochondrial precursor

# Metabolic_Enzyme_11_Synonyms:
(S-3-amino-2-methylpropionate transaminase; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA aminotransferase; GABA-AT; GABA-T; L-AIBAT

# Metabolic_Enzyme_11_Gene_Name:
ABAT

# Metabolic_Enzyme_11_Protein_Sequence:
>4aminobutyrate aminotransferase, mitochondrial precursor
MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMK
QLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQ
NASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYR
SKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPS
FDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGG
DNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMM
TGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLL
DLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVF
RDHHAHLFLNIFSDILADFK

# Metabolic_Enzyme_11_Number_of_Residues:
500

# Metabolic_Enzyme_11_Molecular_Weight:
56440

# Metabolic_Enzyme_11_Theoretical_pI:
8.04

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  4-aminobutyrate transaminase activity
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid derivative metabolism
Process:  gamma-aminobutyric acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine

# Metabolic_Enzyme_11_Pathway:
map00280  Valine, leucine and isoleucine degradation;
GENES       ECO: b2662(gabT);
            ECJ: JW2637(gabT);
            ECE: Z3960(gabT);
            ECS: ECs3523;
            ECC: c3210(gabT);
            STY: STY2912(gabT);
            STT: t2687(gabT);
            SPT: SPA2649(gabT);
            SEC: SC2724(gabT);
            STM: STM2792(gabT);
            YPE: YPO2844(goaG);
            YPK: y1390(goaG);
            YPM: YP2711(goaG);
            YPS: YPTB2810(goaG);
            SFL: SF2689(gabT);
            SFX: S2874(gabT);
            ECA: ECA2053(gabT);
            PLU: plu2347(goaG);
            VPA: VP1771;
            PAE: PA0266(gabT);
            PPU: PP0214(gabT);
            PST: PSPTO0301(gabT-2);
            PSB: Psyr_0090;
            ACI: ACIAD3446(gabT);
            SON: SO1276(gabT);
            CVI: CV3926(goaG);
            RSO: RSc0029(goaG);
            BMA: BMAA1480(gabT);
            BPS: BPSS0281(gabT);
            BPE: BP2298;
            BPA: BPP2431;
            BBR: BB1880;
            MLO: mlr5521;
            SME: SMb21186(gabT);
            RPA: RPA2323(goaT);
            SIL: SPOA0274(gabT);
            BAN: BA0325(gabT);
            BAR: GBAA0325(gabT);
            BAA: BA_0895;
            BAT: BAS0310;
            BCA: BCE0354(gabT);
            BCZ: BCZK0297(gabT)

# Metabolic_Enzyme_11_Reaction:
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00202:Aminotran_3

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.6.1.19;EC 2.6.1.22

# Metabolic_Enzyme_11_GenBank_ID_Protein:
602705

# Metabolic_Enzyme_11_SwissProt_ID:
GABT_HUMAN (P80404)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
ABAT

# Metabolic_Enzyme_11_Geneatlas_id:
ABAT

# Metabolic_Enzyme_11_hgnc_id:
HGNC:23

# Metabolic_Enzyme_11_PDB_ID:
1OHY

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_11_Gene_Sequence:
>1503 bp
ATGGCCTCCATGTTGCTCGCCCAGCGGCTGGCCTGCAGCTTCCAGCACACGTACCGCCTG
CTGGTGCCTGGATCCAGACACATTAGTCAAGCTGCAGCCAAAGTCGACGTTGAATTTGAT
TATGATGGGCCTCTGATGAAGACGGAAGTCCCAGGGCCTAGATCTCAGGAGTTAATGAAA
CAGCTGAATATAATTCAGAATGCAGAGGCTGTGCATTTTTTCTGCAATTACGAAGAGAGC
CGAGGCAATTACCTGGTTGATGTGGACGGCAACCGAATGCTGGATCTTTATTCCCAGATC
TCCTCTGTTCCCATAGGTTACAGCGACCCGGCCCTCGTGAAACTCATCCAACAGCCACAA
AATGCGAGCATGTTTGTCAACAGACCCGCCCTCGAAATCCTGCCTCCGGAGAACTTTGTG
GAGAAGCTCCGGCAGTCCTTGCTCTCGGTGGCTCCCAAAGGGATGTCCCAGCTCATCACC
ATGGCCTGCGGCTCCTGCTCCAATGAAAACGCCTTAAAGACCATCTTCATGTGGTACCGG
AGCAAGGAAAGAGGGCAGAGGGGATTCTCCAAAGAGGAGCTGGAGACGTGCATGATTAAC
CAGGCCCCCTGGTGCCCCGACTACAGCATCCTCTCCTTCATGGGTTCCTTCCATGGGAGG
ACCATGGGTTGCTTAGCGACCACGCACTCTAAAGCCATTCACAAGATCGATATCCCTTCC
TTTGACTGGCCCATCGCACCGTTCCCACGGCTGAAATACCCTCTGGAAGAGTTTGTGAAA
GAGAACCAACAGGAAGAGGCCGGCTGTCTGGAAGAGGTTGAGGATCTGATTGTGAAATAT
CGAAAAAAGAAGAAGACGGTGGCCGGGATCATCGTGGAGCCCATCCAGTCCGAGGGTGGA
GACAACCATGCATCCGATGACTTCTTTCGGAAGCTGAGAGACATCGCCAGGAAGCACTGC
TGCGCCTTCTTGGTGGACGAGGTCCAGACCGGAGGAGGCTGCACGGGCAAGTTCTGGGCC
CATGAGCACTGGGGCCTGGATGACCCAGCAGACGTGATGACCTTCAGCAAGAAGATGATG
ACTGGGGGCTTCTTCCTCAAGGAGGAGTTCAGGCCTAATGCTCCCTACCGGATCTTCAAC
ACGTGGCTGGGGGACCCGTCCAAGAACCTGTTGCTGGCTGAGGTCATCAACATCATCAAG
CGGGAGGACCTGCTAAATAATGCAGCCCATGCCGGGAAGGCCCTGCTCACAGGACTGCTG
GACCTCCAGGCCCGGTACCCCCAGTTCATCAGCAGGGTGAGAGGACGAGGCACCTTTTGC
TCCTTCGATACTCCCGATGATTCCATACGGAATAAGCTCATTTTAATTGCCAGAAACAAA
GGTGTGGTGTTGGGTGGCTGTGGTGACAAATCCATTCGTTTCCGTCCCACGCTGGTGTTC
AGGGATCACCACGCTCACCTGTTCCTCAATATTTTCAGTGACATCTTAGCAGACTTCAAG
TAA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
L32961

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_11_Locus:
16p13.2

# Metabolic_Enzyme_11_SNPs:
rs1731017; rs1641022; rs28687443; rs1731062; rs1006636; rs747329; rs1730951; rs1273350; rs1273394; rs1730948; rs4454975; rs3743801; rs1730946; rs6497519; rs1730941; rs2313427; rs1641113; rs1273364; rs4984996; rs1641107; rs747330; rs1273396; rs11075408; rs6497548; rs1730945; rs6497583; rs1295741; rs1641112; rs1273373; rs1640989; rs1273357; rs4985113; rs8062395; rs1730952; rs7205816; rs1641032; rs3108684; rs1730954; rs1273393; rs7199025; rs4985114; rs4985036; rs1730958; rs9935902; rs1641110; rs6497327; rs4985000; rs1273351; rs8055836; rs1641108; rs1344476; rs1730938; rs1730953; rs1730943; rs1641111; rs1730937; rs4984997; rs17566580; rs737695; rs3095512; rs1289964; rs1273360; rs1273397; rs9456; rs1273381; rs1273359; rs1731071; rs1273353; rs1640997; rs3743798; rs1273355; rs9935408; rs6498753; rs17674530; rs1273356; rs12933164; rs1273376; rs1730956; rs1273361; rs1273390; rs12447371; rs12596289; rs1731083; rs1641031; rs12445987; rs12597124; rs4445904; rs11648372; rs1640995; rs1730961; rs1273395; rs11645254; rs9935422; rs1295740; rs11647162; rs4984998; rs11646372; rs1273366; rs1640979; rs7499026; rs2313548; rs6498755; rs1640980; rs3095514; rs1273372; rs1273363; rs6497565; rs11074405; rs1273358; rs1731061; rs1273382; rs1730955; rs1273352; rs1273367; rs7499025; rs1640971; rs7201586; rs1730949; rs1640974; rs1641106; rs8052707; rs1612155; rs1273391; rs12596654; rs12448579; rs1641109; rs1807439; rs8056063; rs1273349; rs1731081; rs1731082; rs9923953; rs8059639; rs3095516; rs1730944; rs11642785; rs8061555; rs1061842; rs1641105; rs8056550; rs12149040; rs1731078; rs7194430; rs1730959; rs1420082; rs12448693; rs12597484; rs737696; rs1273380; rs1273370; rs8058062; rs1640973; rs1731069; rs1730947; rs1731085; rs1731079; rs2270289; rs3095515; rs1640978; rs1640981; rs1730962; rs1640996; rs9939980; rs1123891; rs8054014; rs1273369; rs1730957; rs9928478; rs8046210; rs12921061; rs2270288; rs7501036; rs11648678; rs1273383; rs1273362; rs11643667; rs1730939; rs1881828; rs1640988; rs2313596; rs12444390; rs1731080; rs17651562; rs16964282; rs9935013; rs7193087; rs11866675; rs8275; rs10261; rs12445958; rs1731070; rs737694; rs8048045; rs7192026; rs7197787; rs8050233; rs1640994; rs3095513; rs8049263; rs12447028; rs11643578; rs3095510; rs1641021; rs9674265; rs8057362; rs1273427; rs1641024; rs1273398; rs1273422; rs1273424; rs2091634; rs7196462; rs1273430; rs1640998; rs8053509; rs8049072; rs9673595; rs12708689; rs4985035; rs1641003; rs1641019; rs6497960; rs7197673; rs1273425; rs12447235; rs1273429; rs8055880; rs1641025; rs1273433; rs3815507; rs1079350; rs4482281; rs11863437; rs1273423; rs1731039; rs1731019; rs1640999; rs1641007; rs12446980; rs12925086; rs13337024; rs13336159; rs9937726; rs933481; rs1273431; rs1641014; rs12446169; rs8060255; rs1641002; rs1078509; rs1273417; rs1641027; rs1641016; rs1731027; rs12448959; rs6497959; rs1273428; rs1079348; rs11862060; rs11074631; rs2103340; rs753071; rs1731026; rs1731072; rs1299926; rs1273420; rs8055737; rs12448823; rs1079349; rs1731086; rs7203297; rs1273406; rs3815508; rs1641001; rs8061093; rs9937937; rs9302405; rs11640989; rs8056083; rs11866199; rs1273426; rs9924807; rs1273419; rs1273402; rs1641030; rs7206830; rs1273421; rs8053030; rs12596790; rs8046201; rs11865147; rs1731087; rs1731073; rs13338443; rs1273415; rs12918897; rs1641010; rs8055927; rs11074534; rs13335330; rs1731030; rs1641015; rs9929124; rs10775278; rs1641023; rs1420084; rs9673228; rs7193333; rs1990574; rs1894861; rs1965648; rs1078511; rs1731020; rs1641008; rs1731034; rs1273407; rs1612383; rs11647952; rs2464048; rs1731018; rs9673371; rs7193305; rs1641011; rs1273416; rs1273400; rs11074713; rs1641029; rs9673409; rs1465319; rs1965649; rs1420085; rs10775279; rs11860865; rs12445730; rs11641035; rs1273408; rs7200886; rs1630164; rs13332999; rs1731029; rs1273401; rs1616856; rs1273412; rs1273418; rs12445609; rs11074695; rs8057162; rs13336186; rs11074533; rs1075853; rs1273413; rs11074712; rs3217123; rs9673401; rs1641026; rs12922831; rs12445687; rs13332215; rs12102631; rs12598074; rs12444233; rs1731036; rs1641006; rs12930556; rs12325344; rs933482; rs13339338; rs1613314; rs1965647; rs8061716; rs4989413; rs2302608; rs1641013; rs8048375; rs1617601; rs12448478; rs1273410; rs1465318; rs8060512; rs1641017; rs12149331; rs13331042; rs8047293; rs4984999; rs11646271; rs10852271; rs9925620; rs10775277; rs8060323; rs9931017; rs1420083; rs7203550; rs1641104; rs1139523; rs1139520; rs35780038; rs41311264; rs1139522; rs1062593; rs1139525; rs34813662; rs1042495; rs1139521; rs1139519; rs8059762; rs35850996; rs1273386; rs1640972; rs34187437; rs12597184; rs28415910; rs7195521; rs36138946; rs28587720; rs1640985; rs12149146; rs1731059; rs34441266; rs28403171; rs9939846; rs1640993; rs1273377; rs34595424; rs35454761; rs1273378; rs7195079; rs35916063; rs1640987; rs1273371; rs9928667; rs4296259; rs13334372; rs28382303; rs35255805; rs33951087; rs1630895; rs1731084; rs1273388; rs16964376; rs34014796; rs35351214; rs1730950; rs7184890; rs34724138; rs1640977; rs4442807; rs1731064; rs17651173; rs7204053; rs1273374; rs1730960; rs2178371; rs1640975; rs3095511; rs2160182; rs13337410; rs35163930; rs28692588; rs8056066; rs34165726; rs1731075; rs35012807; rs35638621; rs1640986; rs5815494; rs28602865; rs1273368; rs1640992; rs28622536; rs1731058; rs12149145; rs7190843; rs28714127; rs35832558; rs8056594; rs1986108; rs33928355; rs1640984; rs34006471; rs8060892; rs28742255; rs9746220; rs12926736; rs35163795; rs1273365; rs34531177; rs3065947; rs1640991; rs34595884; rs34089650; rs35176944; rs34736230; rs2313428; rs10163233; rs1731057; rs8049522; rs730750; rs34452392; rs9941133; rs34403235; rs34698480; rs1640970; rs34686381; rs8056020; rs7196194; rs35069718; rs28581915; rs28589960; rs8046394; rs34733640; rs1640983; rs12446703; rs13337518; rs28609006; rs1730942; rs1731076; rs7187850; rs35596444; rs8046003; rs28864687; rs1640990; rs12325121; rs8046571; rs9931939; rs8044285; rs7203755; rs41312250; rs8062725; rs28618356; rs13338663; rs7195524; rs28650912; rs35853974; rs34216922; rs13333072; rs10163342; rs12925473; rs1273379; rs7499024; rs1273387; rs5815492; rs13338551; rs7498949; rs34887951; rs28397834; rs7196287; rs28568507; rs2052235; rs34327953; rs34516341; rs28679855; rs35724649; rs11861413; rs7206673; rs2160181; rs1627524; rs35141742; rs1731077; rs1641114; rs13336886; rs12149463; rs35336676; rs34655579; rs9934284; rs35896679; rs1730940; rs8046260; rs1273375; rs28430948; rs3069301; rs35773832; rs28483683; rs5815493; rs11642744; rs8052663; rs1273389; rs12445001; rs35804023; rs35621836; rs1273392; rs3108683; rs34943374; rs1640982; rs35771183; rs4985115; rs1640976; rs1731088; rs12932819; rs35772192; rs34403809; rs34264472; rs9931477; rs8063475; rs1731024; rs11862275; rs36095894; rs753070; rs1273403; rs1298679; rs1630161; rs34085775; rs28785577; rs7192987; rs33948976; rs13337697; rs3069345; rs12924611; rs1731068; rs1465317; rs13339388; rs28557212; rs34198010; rs6497761; rs7188839; rs13337020; rs12921235; rs28669991; rs12598010; rs1078510; rs1320812; rs35617486; rs13338915; rs12445356; rs9674283; rs36191361; rs1273404; rs11647647; rs34543657; rs7198302; rs12924829; rs34544015; rs36181426; rs1627098; rs1731038; rs9923086; rs1273411; rs36055711; rs10153069; rs1641004; rs1731033; rs1657081; rs35468187; rs13337062; rs7200508; rs7185579; rs35255659; rs11649570; rs34994165; rs35503372; rs12598506; rs1641018; rs1731037; rs34598069; rs34415556; rs41307917; rs11648982; rs34761392; rs1273405; rs1548863; rs1641000; rs34630251; rs2464049; rs28568366; rs12930438; rs7205552; rs1299925; rs9941328; rs28759346; rs34495251; rs1641012; rs34900184; rs1629364; rs11862270; rs9936820; rs9926653; rs34177196; rs41312254; rs7200724; rs9932833; rs35002036; rs12935717; rs28852097; rs1273409; rs35359682; rs753072; rs10852270; rs28427346; rs35691630; rs11640314; rs10775276; rs1731025; rs28495577; rs34651404; rs34982194; rs35248639; rs36034133; rs1078508; rs12149630; rs35745596; rs9926200; rs36000891; rs7187363; rs8060324; rs7189861; rs13339115; rs35414822; rs34346487; rs35585805; rs41303767; rs35010946; rs933480; rs12447747; rs41305755; rs35405936; rs28630033; rs9941032; rs41427146; rs9922301; rs7191001; rs2313560; rs41312252; rs41311266; rs13338171; rs13339497; rs1641005; rs34408519; rs13380503; rs34755382; rs7500881; rs13335619; rs1273432; rs9936647; rs35893143; rs1273414; rs34060423; rs1623647; rs34484640; rs11647644; rs35548548; rs28398424; rs1730964; rs35258023; rs1730963; rs35440533; rs28758216; rs1060784; rs11641192; rs11860988; rs11861249; rs12103329; rs12444391; rs12444975; rs12447079; rs1273384; rs1273385; rs12929416; rs13338256; rs1345300; rs1358692; rs1641098; rs1641099; rs1641100; rs1641101; rs1865805; rs1865806; rs2160180; rs2241103; rs2312957; rs2840195; rs34611261; rs35851221; rs3743811; rs3743812; rs4985110; rs4985111; rs7188782; rs7192702; rs7200823; rs7204765; rs7205295; rs876945; rs9928906

# Metabolic_Enzyme_11_General_References:
7721088; 7851425; 10407778

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5529

# Metabolic_Enzyme_12_Name:
Aldehyde dehydrogenase 1A3

# Metabolic_Enzyme_12_Synonyms:
Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3

# Metabolic_Enzyme_12_Gene_Name:
ALDH1A3

# Metabolic_Enzyme_12_Protein_Sequence:
>Aldehyde dehydrogenase 1A3
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI
CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM
DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW
NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV
GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE
CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK
QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL
KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF
KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP

# Metabolic_Enzyme_12_Number_of_Residues:
512

# Metabolic_Enzyme_12_Molecular_Weight:
56109

# Metabolic_Enzyme_12_Theoretical_pI:
7.29

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_12_Specific_Function:
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system

# Metabolic_Enzyme_12_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_12_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_12_Signals:
None

# Metabolic_Enzyme_12_Transmembrane_Regions:
None

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_12_GenBank_ID_Protein:
544482

# Metabolic_Enzyme_12_SwissProt_ID:
AL1A3_HUMAN (P47895)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
ALDH1A3

# Metabolic_Enzyme_12_Geneatlas_id:
ALDH1A3

# Metabolic_Enzyme_12_hgnc_id:
HGNC:409

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_12_Gene_Sequence:
>1539 bp
ATGGCCACCGCTAACGGGGCCGTGGAAAACGGGCAGCCGGACGGGAAGCCGCCGGCCCTG
CCGCGCCCCATCCGCAACCTGGAGGTCAAGTTCACCAAGATATTTATCAACAATGAATGG
CACGAATCCAAGAGTGGGAAAAAGTTTGCTACATGTAACCCTTCAACTCGGGAGCAAATA
TGTGAAGTGGAAGAAGGAGATAAGCCCGACGTGGACAAGGCTGTGGAGGCTGCACAGGTT
GCCTTCCAGAGGGGCTCGCCATGGCGCCGGCTGGATGCCCTGAGTCGTGGGCGGCTGCTG
CACCAGCTGGCTGACCTGGTGGAGAGGGACCGCGCCACCTTGGCCGCCCTGGAGACGATG
GATACAGGGAAGCCATTTCTTCATGCTTTTTTCATCGACCTGGAGGGCTGTATTAGAACC
CTCAGATACTTTGCAGGGTGGGCAGACAAAATCCAGGGCAAGACCATCCCCACAGATGAC
AACGTCGTATGCTTCACCAGGCATGAGCCCATTGGTGTCTGTGGGGCCATCACTCCATGG
AACTTCCCCCTGCTGATGCTGGTGTGGAAGCTGGCACCCGCCCTCTGCTGTGGGAACACC
ATGGTCCTGAAGCCTGCGGAGCAGACACCTCTCACCGCCCTTTATCTCGGCTCTCTGATC
AAAGAGGCCGGGTTCCCTCCAGGAGTGGTGAACATTGTGCCAGGATTCGGGCCCACAGTG
GGAGCAGCAATTTCTTCTCACCCTCAGATCAACAAGATCGCCTTCACCGGCTCCACAGAG
GTTGGAAAACTGGTTAAAGAAGCTGCGTCCCGGAGCAATCTGAAGCGGGTGACGCTGGAG
CTGGGGGGGAAGAACCCCTGCATCGTGTGTGCGGACGCTGACTTGGACTTGGCAGTGGAG
TGTGCCCATCAGGGAGTGTTCTTCAACCAAGGCCAGTGTTGCACGGCAGCCTCCAGGGTG
TTCGTGGAGGAGCAGGTCTACTCTGAGTTTGTCAGGCGGAGCGTGGAGTATGCCAAGAAA
CGGCCCGTGGGAGACCCCTTCGATGTCAAAACAGAACAGGGGCCTCAGATTGATCAAAAG
CAGTTCGACAAAATCTTAGAGCTGATCGAGAGTGGGAAGAAGGAAGGGGCCAAGCTGGAA
TGCGGGGGCTCAGCCATGGAAGACAAGGGGCTCTTCATCAAACCCACTGTCTTCTCAGAA
GTCACAGACAACATGCGGATTGCCAAAGAGGAGATTTTCGGGCCAGTGCAACCAATACTG
AAGTTCAAAAGTATCGAAGAAGTGATAAAAAGAGCGAATAGCACCGACTATGGACTCACA
GCAGCCGTGTTCACAAAAAATCTCGACAAAGCCCTGAAGTTGGCTTCTGCCTTAGAGTCT
GGAACGGTCTGGATCAACTGCTACAACGCCCTCTATGCACAGGCTCCATTTGGTGGCTTT
AAAATGTCAGGAAATGGCAGAGAACTAGGTGAATACGCTTTGGCCGAATACACAGAAGTG
AAAACTGTCACCATCAAACTTGGCGACAAGAACCCCTGA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
U07919

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_12_Locus:
15q26.3

# Metabolic_Enzyme_12_SNPs:
rs3803430; rs2229183; rs1130738; rs14226; rs3803424; rs7045; rs3803426; rs7182089; rs4646690; rs7161860; rs4246328; rs4646688; rs4646668; rs4646670; rs3803428; rs4646671; rs6598396; rs4646675; rs9944290; rs7181897; rs4646684; rs4246323; rs4246327; rs4246329; rs4646674; rs8039374; rs4646678; rs4646653; rs4646655; rs7182884; rs3809521; rs11854028; rs3825926; rs3803433; rs6598397; rs4646662; rs4646685; rs4646651; rs4646672; rs3922685; rs4646654; rs3902902; rs4646683; rs7176046; rs3803432; rs4246324; rs4646661; rs8030776; rs12903828; rs4646687; rs4646680; rs3825925; rs7178221; rs3803427; rs7170197; rs4246325; rs8023972; rs4646681; rs7167278; rs4246326; rs1886; rs4646649; rs12908902; rs7171776; rs3803429; rs12914598; rs4646669; rs4646650; rs3803434; rs4646660; rs4646682; rs3809524; rs3809523; rs3809526; rs7179268; rs1130737; rs3803431; rs1130768; rs34302490; rs28760343; rs35300460; rs1802602; rs1802604; rs4288979; rs3803425; rs1802603; rs4646663; rs28691047; rs28731371; rs34655770; rs35165034; rs28509297; rs10400871; rs35129664; rs12905372; rs28405557; rs34486175; rs28546254; rs35055541; rs4646686; rs28441320; rs28410143; rs4646676; rs4646648; rs8029933; rs12910188; rs34182689; rs28504296; rs28449981; rs28507582; rs3825927; rs35310246; rs12910025; rs28384196; rs4343265; rs12910662; rs8028283; rs28475530; rs4392045; rs28369514; rs28377287; rs8035722; rs28480133; rs28707102; rs28583888; rs4646666; rs7173413; rs28472416; rs28673034; rs28668881; rs28711429; rs34837038; rs4646659; rs28452487; rs28712665; rs12910029; rs12902704; rs4646673; rs28689536; rs28431101; rs34431941; rs7178645; rs28454526; rs7170202; rs1889; rs4646647; rs4375646; rs11348272; rs4646656; rs28408085; rs28699556; rs28615197; rs28539744; rs28557216; rs28631565; rs34302839; rs3923499; rs4646664; rs35740226; rs28385499; rs3922686; rs28474807; rs28490217; rs12909825; rs10593974; rs28679806; rs28610999; rs7178553; rs35519561; rs35831758; rs35526807; rs4646658; rs28538652; rs28685242; rs10400842; rs4646667; rs35948146; rs4646677; rs7165217; rs10400872; rs28750207; rs3825924; rs7171453; rs34906846; rs4646665; rs9920154; rs36081993; rs11435500; rs28464660; rs4646679; rs12595234; rs4646689; rs3809522; rs35950557; rs3809527; rs7172149; rs7178931; rs8034153; rs7183889; rs3809525; rs4646646; rs11630601; rs11630691; rs11632820; rs11637204; rs11854709; rs12148466; rs12148493; rs12440023; rs12593839; rs12901792; rs12907776; rs12908105; rs12909230; rs12909791; rs28507591; rs3803435; rs4346184; rs4646694; rs7163108; rs7164136; rs7181644; rs8034686; rs8035036

# Metabolic_Enzyme_12_General_References:
7698756

# Metabolic_Enzyme_12_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8896

# Macromolecular_Interacting_Partner_1_Name:
Vesicular inhibitory amino acid transporter

# Macromolecular_Interacting_Partner_1_Synonyms:
GABA and glycine transporter; Vesicular GABA transporter; hVIAAT; Solute carrier family 32 member 1

# Macromolecular_Interacting_Partner_1_Gene_Name:
SLC32A1

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Vesicular inhibitory amino acid transporter
MATLLRSKLSNVATSVSNKSQAKMSGMFARMGFQAATDEEAVGFAHCDDLDFEHRQGLQM
DILKAEGEPCGDEGAEAPVEGDIHYQRGSGAPLPPSGSKDQVGGGGEFGGHDKPKITAWE
AGWNVTNAIQGMFVLGLPYAILHGGYLGLFLIIFAAVVCCYTGKILIACLYEENEDGEVV
RVRDSYVAIANACCAPRFPTLGGRVVNVAQIIELVMTCILYVVVSGNLMYNSFPGLPVSQ
KSWSIIATAVLLPCAFLKNLKAVSKFSLLCTLAHFVINILVIAYCLSRARDWAWEKVKFY
IDVKKFPISIGIIVFSYTSQIFLPSLEGNMQQPSEFHCMMNWTHIAACVLKGLFALVAYL
TWADETKEVITDNLPGSIRAVVNIFLVAKALLSYPLPFFAAVEVLEKSLFQEGSRAFFPA
CYSGDGRLKSWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRL
LWRKLLWHQVFFDVAIFVIGGICSVSGFVHSLEGLIEAYRTNAED

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
525

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
57416

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.63

# Macromolecular_Interacting_Partner_1_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_1_Specific_Function:
Involved in the uptake of GABA and glycine into the synaptic vesicles

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_1_Signals:
Not Available

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
134-154
205-225
243-263
266-286
306-326
342-362
384-404
439-459
462-482
490-510

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
17975777

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
VIAAT_HUMAN (Q9H598)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
SLC32A1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
SLC32A1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:11018

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cytoplasmic vesicle; cytoplasmic vesicle membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1578 bp
ATGGCCACCTTGCTCCGCAGCAAGCTGTCCAACGTGGCCACGTCCGTGTCCAACAAGTCC
CAGGCCAAGATGAGCGGCATGTTCGCCAGGATGGGTTTTCAGGCGGCCACGGATGAGGAG
GCGGTGGGCTTCGCGCATTGCGACGACCTCGACTTTGAGCACCGCCAGGGCCTGCAGATG
GACATCCTGAAAGCCGAGGGAGAGCCCTGCGGGGACGAGGGCGCTGAAGCGCCCGTCGAG
GGAGACATCCATTATCAGCGAGGCAGCGGAGCTCCTCTGCCGCCCTCCGGCTCCAAGGAC
CAGGTGGGAGGTGGTGGCGAATTCGGGGGCCACGACAAGCCCAAAATCACGGCGTGGGAG
GCAGGCTGGAACGTGACCAACGCCATCCAGGGCATGTTCGTGCTGGGCCTACCCTACGCC
ATCCTGCACGGCGGCTACCTGGGGTTGTTTCTCATCATCTTCGCCGCCGTTGTGTGCTGC
TACACCGGCAAGATCCTCATCGCGTGCCTGTACGAGGAGAATGAAGACGGCGAGGTGGTG
CGCGTGCGGGACTCGTACGTGGCCATAGCCAACGCCTGCTGCGCCCCGCGCTTCCCAACG
CTGGGCGGCCGAGTGGTGAACGTAGCGCAGATCATCGAGCTGGTGATGACGTGCATCCTG
TACGTGGTGGTGAGTGGCAACCTCATGTACAACAGCTTCCCGGGGCTGCCCGTGTCGCAG
AAGTCCTGGTCCATTATCGCCACGGCCGTGCTGCTGCCTTGCGCCTTCCTTAAGAACCTC
AAGGCCGTGTCCAAGTTCAGTCTGCTGTGCACTCTGGCCCACTTCGTCATCAATATCCTG
GTCATAGCCTACTGTCTATCGCGGGCGCGCGACTGGGCCTGGGAGAAGGTCAAGTTCTAC
ATCGACGTCAAGAAGTTCCCCATCTCCATTGGCATCATCGTGTTCAGCTACACGTCTCAG
ATCTTCCTGCCTTCGCTGGAGGGCAATATGCAGCAGCCCAGCGAGTTCCACTGCATGATG
AACTGGACGCACATCGCAGCCTGCGTGCTCAAGGGCCTCTTCGCGCTCGTCGCCTACCTC
ACCTGGGCCGACGAGACCAAGGAGGTCATCACGGATAACCTGCCCGGCTCCATCCGCGCC
GTGGTCAACATCTTTCTGGTGGCCAAGGCGCTGTTGTCCTATCCTCTGCCATTCTTTGCC
GCTGTCGAGGTGCTGGAGAAGTCGCTCTTCCAGGAAGGCAGCCGCGCCTTTTTCCCGGCC
TGCTACAGCGGCGACGGGCGCCTGAAGTCCTGGGGGCTGACGCTGCGCTGCGCGCTCGTC
GTCTTCACGCTGCTCATGGCCATTTATGTGCCGCACTTCGCGCTGCTCATGGGCCTCACC
GGCAGCCTCACGGGCGCCGGCCTCTGTTTCTTGCTGCCCAGCCTCTTTCACCTGCGCCTG
CTCTGGCGCAAGCTGCTGTGGCACCAAGTCTTCTTCGACGTCGCCATCTTCGTCATCGGC
GGCATCTGCAGCGTGTCCGGCTTCGTGCACTCCCTCGAGGGCCTCATCGAAGCCTACCGA
ACCAACGCGGAGGACTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AY044836

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_1_Locus:
20q11.23

# Macromolecular_Interacting_Partner_1_SNPs:
rs34517228; rs16987520; rs16987519; rs6128821; rs6128822; rs8118790; rs6064926; rs4328688; rs6100927; rs6100928; rs6100926; rs2865; rs41304659; rs6100930; rs6027611; rs6027610; rs34068158; rs41311047; rs41305815; rs11477723; rs6027609; rs2867326; rs8125102; rs6071200; rs13042447; rs1010321; rs11700227; rs11906418; rs12624979; rs1321099; rs1322183; rs1406857; rs1406858; rs16987521; rs16987523; rs2180224; rs2246443; rs2246672; rs2246804; rs2247054; rs2263747; rs2757515; rs6027580; rs6064941; rs6071237; rs6092933; rs6092935; rs6092955; rs6100937; rs6100962; rs6128836; rs7274633; rs733549; rs911717; rs911718; rs911719; rs997848; rs998277

# Macromolecular_Interacting_Partner_1_General_References:
12031963; 11780052; 12115694

# Macromolecular_Interacting_Partner_1_References:
Not Available

End of HMDB00056

Beginning of HMDB00058
# Accession_No:
HMDB00058

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-08 11:29:49

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Cyclic AMP

# Description:
Cyclic AMP is an adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.  cAMP is synthesized from ATP by adenylate cyclase. Adenylate cyclase is located at the cell membranes. Adenylate cyclase is activated by the hormones glucagon and adrenaline and by G protein. Liver adenylate cyclase responds more strongly to glucagon, and muscle adenylate cyclase responds more strongly to adrenaline.  cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase.

# Synonyms:
Cyclic AMP; 3'5'-cyclic AMP; 6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide; Acrasin; Adenosine 3',5'-cyclic monophosphate; Adenosine 3',5'-cyclic phosphate; Adenosine 3',5'-cyclophosphate; Adenosine 3',5'-monophosphate; Adenosine 3,5'-cyclic monophosphorate; Adenosine 3,5'-cyclic monophosphoric acid; Adenosine cyclic monophosphate; Cyclic 3',5'-AMP; Cyclic 3',5'-adenylate; Cyclic 3',5'-adenylic acid; Cyclic adenosine 3',5'-phosphate; adenosine cyclic-monophosphate; adenosine-cyclic-phosphate; adenosine-cyclic-phosphoric-acid; cAMP

# Chemical_IUPAC_Name:
8-(6-aminopurin-9-yl)-4-hydroxy-4-oxo-3,5,9-trioxa-4$l^{5}-phosphabicyclo[4.3.0]nonan-7-ol

# Chemical_Formula:
C10H12N5O6P

# Chemical_Structure:
tbl_chemical:::HMDB00058_ZOOM.png:::119283163172764037

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00058_THUMB.png:::119283162945955144

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines; Nucleoside Phosphates

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; secondary alcohol; primary amine; primary aromatic amine; phosphoric acid ester; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Second messenger; Component of Purine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
329.05252

# Molecular_Weight_Avg:
329.20593

# Smiles_String_isomeric:
NC1=NC=NC2=C1N=CN2[C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O

# Smiles_String_canonical:
NC1=NC=NC2=C1N=CN2C3OC4COP(O)(=O)OC4C3O

# KEGG_Compound_ID:
C00575

# BioCyc_ID:
CAMP

# PubChem_CID:
6076

# PubChem_SID:
820438; 3882616; 148964; 3139529; 836189; 10322184; 831763; 603443; 855208; 827602; 828210; 825529; 835819; 3854; 11533120; 832027; 7886670; 822448; 828207; 832026; 10322185; 10322186; 584554; 841066; 828209; 10322127; 834521; 830091; 822436; 854687; 825879; 830055; 8153795; 828208; 10322183

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
1484809

# Wikipedia_ID:
Cyclic AMP

# METLIN_ID:
5120

# Ref_ID:
6311112; 16113412; 2982489; 9323090; 16299606; 16460680; 16028444; 6283833; 2846659; 16460956; 9637723; 15220017; 16098715; 180045; 16825601; 6326460; 6294426; 16026507; 6317236; 12973949

# ChEBI_ID:
17489

# CAS_Registry_Number:
60-92-4

# InChI:
InChI=1/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1

# Synthesis_Reference:
 Journal of the Chemical Society, Chemical Communications  (1985),   (18),  1225-6.

# Melting_Point:
219-220 oC

# Melting_Point_predicted:
162.2 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
4 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
136.0 mg/mL [MEYLAN,WM et al. (1996)]; 3.58 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
-2.96 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-2.28 [Predicted by ALOGPS]; -2.5 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00575.mol:::1132723804156849306

# SDF_File_[Text]:
tbl_chemical:::HMDB00058.sdf:::119283162455891663

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00058.pdb:::119283162778389665

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::050105_P00_02_IS_1DP_Presat.png:::116232086831576236

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::050105_P00_02_IS_1DP_1_PRESAT.fid .zip:::114658633330029280

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::050105_P00_02_IS_1DP_Assigned.png:::115635720691975976

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050105_P00_02_IS_2DHSQC_989.png:::114807690511734678

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050105_P00_02_IS_2DHSQC_989.zip:::114807690512430457

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050105_P00_02_IS_2DHSQC_989_Assigned.png:::115101444272060027

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Adenosine 3',5'-cyclic phosphate.gif:::1132732103921285372

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00058_peaks.txt:::1156309517322760385

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Adenosine 3',5'-cyclic phosphate_C.gif:::113273767080670300

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00058_peaks.txt:::1156310707795418722

# Mass_Spectrum:
tbl_chemical:::HMDB00058.jpg:::1132798876109408468

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000071.png:::116899931010938777

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000071.txt:::1168999310109743

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000071.png:::116890825717124915

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000071.txt:::116890825746844079

# Cellular_Location:
Cytoplasm; Extracellular; golgi apparatus

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Mucus; Saliva

# Concentration_[Normal]:
Blood	0.32	umol/L	Adult:>18_yrs_old	Both	Normal	15220017
Cerebrospinal_Fluid(CSF)	0.020 +/- 0.004	umol/L	Adult:>18_yrs_old	Both	Normal	6326460
Cerebrospinal_Fluid(CSF)	0.020+/- 0.004	umol/L	Adult:>18_yrs_old	N/A	Normal	6326460
Cerebrospinal_Fluid(CSF)	0.024 (0.022-0.026)	umol/L	Adult:>18_yrs_old	Both	Normal	12973949
Cerebrospinal_Fluid(CSF)	0.021 +/- 0.008	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	0.020 (0.016-0.024)	umol/L	Adult:>18_yrs_old	Both	Normal	6326460


# Concentration_[Abnormal]:
Cerebrospinal_Fluid(CSF)	0.0110 +/- 0.0028	umol/L	Adult:>18_yrs_old	Both	Idiopathic polyneuritis	6326460
Cerebrospinal_Fluid(CSF)	0.033 +/- 0.012	umol/L	Adult:>18_yrs_old	N/A	serious meningitis	6326460
Cerebrospinal_Fluid(CSF)	0.00860 (0.00620-0.0110)	umol/L	Adult:>18_yrs_old	Both	Hypoxic-ischemic encephalopathy	12973949
Cerebrospinal_Fluid(CSF)	0.014 (0.012-0.017)	umol/L	Adult:>18_yrs_old	Both	Hypoxic-ischemic encephalopathy	12973949
Cerebrospinal_Fluid(CSF)	0.034 (0.021-0.046)	umol/L	Adult:>18_yrs_old	Both	Serous meningitis	6326460
Cerebrospinal_Fluid(CSF)	0.011 (0.0082-0.014)	umol/L	Adult:>18_yrs_old	Both	Idiopathic polyneuritis	6326460


# Associated_Disorders:
Hyperparathyroidism; Hypoxic-ischemic encephalopathy; Idiopathic polyneuritis; Primary Hyperparathyroidism; serious meningitis; Serous meningitis

# Pathway_Names:
Purine metabolism

# Pathway_Images:
Purine_Synthesis.jpg

# KEGG_Images:
map00230

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg

# Pathway_SBMLs:
Purine_Synthesis.xml

# Metabolic_Enzyme_1_ID:
5848

# Metabolic_Enzyme_1_Name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

# Metabolic_Enzyme_1_Synonyms:
Cam-PDE 1B; 63 kDa Cam-PDE

# Metabolic_Enzyme_1_Gene_Name:
PDE1B

# Metabolic_Enzyme_1_Protein_Sequence:
>Calcium/calmodulindependent 3',5'cyclic nucleotide phosphodiesterase 1
BMELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKN
LEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEK
PKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHA
LRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFL
LRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISS
VFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKP
KALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQ
SQIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVV
SFRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD

# Metabolic_Enzyme_1_Number_of_Residues:
536

# Metabolic_Enzyme_1_Molecular_Weight:
61380

# Metabolic_Enzyme_1_Theoretical_pI:
5.22

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Has a preference for cGMP as a substrate

# Metabolic_Enzyme_1_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_1_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00233:PDEase_I;
PF08499:PDEase_I_N

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1621592

# Metabolic_Enzyme_1_SwissProt_ID:
PDE1B_HUMAN (Q01064)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
PDE1B

# Metabolic_Enzyme_1_Geneatlas_id:
PDE1B

# Metabolic_Enzyme_1_hgnc_id:
HGNC:8775

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1611 bp
ATGGAGCTGTCCCCCCGCAGTCCTCCGGAGATGCTGGAGGAGTCGGATTGCCCGTCACCC
CTGGAGCTGAAGTCAGCCCCCAGCAAGAAGATGTGGATTAAGCTTCGGTCTCTGCTGCGC
TACATGGTGAAGCAGTTGGAGAATGGGGAGATAAACATTGAGGAGCTGAAGAAAAATCTG
GAGTACACAGCTTCTCTGCTGGAAGCCGTCTACATAGATGAGACACGGCAAATCTTGGAC
ACGGAGGACGAGCTGCAGGAGCTGCGGTCAGATGCCGTGCCTTCGGAGGTGCGGGACTGG
CTGGCCTCCACCTTCACCCAGCAGGCCCGGGCCAAAGGCCGCCGAGCAGAGGAGAAGCCC
AAGTTCCGAAGCATTGTGCACGCTGTGCAGGCTGGGATCTTCGTGGAACGGATGTTCCGG
AGAACATACACCTCTGTGGGCCCCACTTACTCTACTGCGGTTCTCAACTGTCTCAAGAAC
CTGGATCTCTGGTGCTTTGATGTCTTTTCCTTGAACCAGGCAGCAGATGACCATGCCCTG
AGGACCATTGTTTTTGAGTTGCTGACTCGGCATAACCTCATCAGCCGCTTCAAGATTCCC
ACTGTGTTTTTGATGAGTTTCCTGGATGCCTTGGAGACAGGCTATGGGAAGTACAAGAAT
CCTTACCACAACCAGATCCACGCAGCCGATGTTACCCAGACAGTCCATTGCTTCTTGCTC
CGCACAGGGATGGTGCACTGCCTGTCGGAGATTGAGCTCCTGGCCATCATCTTTGCTGCA
GCTATCCATGATTATGAGCACACGGGCACTACCAACAGCTTCCACATCCAGACCAAGTCA
GAATGTGCCATCGTGTACAATGATCGTTCAGTGCTGGAGAATCACCACATCAGCTCTGTT
TTCCGATTGATGCAGGATGATGAGATGAACATTTTCATCAACCTCACCAAGGATGAGTTT
GTAGAACTCCGAGCCCTGGTCATTGAGATGGTGTTGGCCACAGACATGTCCTGCCATTTC
CAGCAAGTGAAGACCATGAAGACAGCCTTGCAACAGCTGGAGAGGATTGACAAGCCCAAG
GCCCTGTCTCTACTGCTCCATGCTGCTGACATCAGCCACCCAACCAAGCAGTGGTTGGTC
CACAGCCGTTGGACCAAGGCCCTCATGGAGGAATTCTTCCGTCAGGGTGACAAGGAGGCA
GAGTTGGGCCTGCCCTTTTCTCCACTCTGTGACCGCACTTCCACTCTAGTGGCACAGTCT
CAGATAGGGTTCATCGACTTCATTGTGGAGCCCACATTCTCTGTGCTGACTGACGTGGCA
GAGAAGAGTGTTCAGCCCCTGGCGGATGAGGACTCCAAGTCTAAAAACCAGCCCAGCTTT
CAGTGGCGCCAGCCCTCTCTGGATGTGGAAGTGGGAGACCCCAACCCTGATGTGGTCAGC
TTTCGTTCCACCTGGGTCAAGCGCATTCAGGAGAACAAGCAGAAATGGAAGGAACGGGCA
GCAAGTGGCATCACCAACCAGATGTCCATTGACGAGCTGTCCCCCTGTGAAGAAGAGGCC
CCCCCATCCCCTGCCGAAGATGAACACAACCAGAATGGGAATCTGGATTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U56976

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_1_Locus:
12q13

# Metabolic_Enzyme_1_SNPs:
rs1249950; rs884510; rs1249951; rs1022232; rs3782403; rs1976823; rs1153138; rs11170969; rs1874308; rs7954532; rs7308435; rs1874309; rs3782404; rs1153137; rs1249949; rs4759090; rs3782411; rs11170973; rs11170974; rs2280426; rs3782410; rs11170976; rs10747699; rs1874305; rs1619029; rs1874307; rs1826728; rs1795814; rs3782405; rs10876566; rs1826729; rs7300897; rs12315671; rs4759091; rs1153136; rs1144995; rs7297522; rs9668037; rs7953703; rs10161382; rs4759092; rs12580297; rs12423459; rs3782409; rs3741670; rs7134688; rs3741671; rs7980139; rs11615709; rs12811737; rs12811532; rs12812036; rs2887906; rs35108378; rs11170978; rs34320482; rs5798310; rs2669404; rs4016630; rs35584396; rs11384809; rs1716335; rs12817930; rs35953387; rs35083639; rs34945831; rs4016629; rs1249684; rs10574598; rs36106145; rs2669406; rs34139185; rs2643610; rs34082972; rs5798309; rs1153139; rs11170971; rs34681049; rs1874306; rs34490177; rs5798308; rs34981158; rs3953265; rs4016627; rs35412225; rs10537588; rs3036634; rs34955742; rs1552957; rs1623252; rs35999388; rs12817736; rs11170972; rs12811907; rs3953266; rs3953264; rs4016628; rs3825194; rs35888172; rs35726390; rs3782407; rs10747698; rs12315672; rs35023953; rs1795817; rs3782408; rs35120300; rs1249948; rs34237967; rs3837464; rs35818150; rs35203189; rs7960002; rs35068189; rs34815974; rs35136005; rs12814787; rs12297247; rs3832832; rs11616154; rs10783631; rs10876567; rs11170968; rs11170979; rs11170980; rs11170981; rs1143960; rs1144996; rs1144997; rs1144998; rs1144999; rs1145000; rs1153140; rs1153141; rs11836274; rs1249499; rs1249682; rs1249683; rs1512905; rs1533235; rs1707483; rs2271981; rs2271982; rs2292490; rs2370971; rs3209081; rs34071274; rs34376731; rs35146181; rs3817412; rs3825195; rs7297136; rs7971175; rs8407

# Metabolic_Enzyme_1_General_References:
8855339; 9419816; 1326532

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5922

# Metabolic_Enzyme_2_Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4A

# Metabolic_Enzyme_2_Synonyms:
DPDE2; PDE46

# Metabolic_Enzyme_2_Gene_Name:
PDE4A

# Metabolic_Enzyme_2_Protein_Sequence:
>cAMPspecific 3',5'cyclic phosphodiesterase 4
AMEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERER
QPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPG
RSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVT
PFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELD
WCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVE
IPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKT
DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM
LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG
VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVID
MVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPL
ELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD
LVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE
EISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYL
TQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGL
PSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT

# Metabolic_Enzyme_2_Number_of_Residues:
886

# Metabolic_Enzyme_2_Molecular_Weight:
98144

# Metabolic_Enzyme_2_Theoretical_pI:
4.87

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate

# Metabolic_Enzyme_2_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_2_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_2_GenBank_ID_Protein:
347120

# Metabolic_Enzyme_2_SwissProt_ID:
PDE4A_HUMAN (P27815)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
PDE4A

# Metabolic_Enzyme_2_Geneatlas_id:
PDE4A

# Metabolic_Enzyme_2_hgnc_id:
HGNC:8780

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Isoform 4:Membrane; peripheral membrane protein. Note=Isoform 4 has propensity for association with membranes

# Metabolic_Enzyme_2_Gene_Sequence:
>2661 bp
ATGGAACCCCCGACCGTCCCCTCGGAAAGGAGCCTGTCTCTGTCACTGCCCGGGCCCCGG
GAGGGCCAGGCCACCCTGAAGCCTCCCCCGCAGCACCTGTGGCGGCAGCCTCGGACCCCC
ATCCGTATCCAGCAGCGCGGCTACTCCGACAGCGCGGAGCGCGCCGAGCGGGAGCGGCAG
CCGCACCGGCCCATAGAGCGCGCCGATGCCATGGACACCAGCGACCGGCCCGGCCTGCGC
ACGACCCGCATGTCCTGGCCCTCGTCCTTCCATGGCACTGGCACCGGCAGCGGCGGCGCG
GGCGGAGGCAGCAGCAGGCGCTTCGAGGCAGAGAATGGGCCGACACCATCTCCTGGCCGC
AGCCCCCTGGACTCGCAGGCGAGCCCAGGACTCGTGCTGCACGCCGGGGCGGCCACCAGC
CAGCGCCGGGAGTCCTTCCTGTACCGCTCAGACAGCGACTATGACATGTCACCCAAGACC
ATGTCCCGGAACTCATCGGTCACCAGCGAGGCGCACGCTGAAGACCTCATCGTAACACCA
TTTGCTCAGGTGCTGGCCAGCCTCCGGAGCGTCCGTAGCAACTTCTCACTCCTGACCAAT
GTGCCCGTTCCCAGTAACAAGCGGTCCCCGCTGGGCGGCCCCACCCCTGTCTGCAAGGCC
ACGCTGTCAGAAGAAACGTGTCAGCAGTTGGCCCGGGAGACTCTGGAGGAGCTGGACTGG
TGTCTGGAGCAGCTGGAGACCATGCAGACCTATCGCTCTGTCAGCGAGATGGCCTCGCAC
AAGTTCAAAAGGATGTTGAACCGTGAGCTCACACACCTGTCAGAAATGAGCAGGTCCGGA
AACCAGGTCTCAGAGTACATTTCCACAACATTCCTGGACAAACAGAATGAAGTGGAGATC
CCATCACCCACGATGAAGGAACGAGAAAAACAGCAAGCGCCGCGACCAAGACCCTCCCAG
CCGCCCCCGCCCCCTGTACCACACTTACAGCCCATGTCCCAAATCACAGGGTTGAAAAAG
TTGATGCATAGTAACAGCCTGAACAACTCTAACATTCCCCGATTTGGGGTGAAGACCGAT
CAAGAAGAGCTCCTGGCCCAAGAACTGGAGAACCTGAACAAGTGGGGCCTGAACATCTTT
TGCGTGTCGGATTACGCTGGAGGCCGCTCACTCACCTGCATCATGTACATGATATTCCAG
GAGCGGGACCTGCTGAAGAAATTCCGCATCCCGGTGGACACGATGGTGACATACATGCTG
ACGCTGGAGGATCACTACCACGCTGACGTGGCCTACCATAACAGCCTGCACGCAGCTGAC
GTGCTGCAGTCCACCCACGTACTGCTGGCCACGCCTGCACTAGATGCAGTGTTCACGGAC
CTGGAGATTCTCGCCGCCCTCTTCGCGGCTGCCATCCACGATGTGGATCACCCTGGGGTC
TCCAACCAGTTCCTCATCAACACCAATTCGGAGCTGGCGCTCATGTACAACGATGAGTCG
GTGCTCGAGAATCACCACCTGGCCGTGGGCTTCAAGCTGCTGCAGGAGGACAACTGCGAC
ATCTTCCAGAACCTCAGCAAGCGCCAGCGGCAGAGCCTACGCAAGATGGTCATCGACATG
GTGCTGGCCACGGACATGTCCAAGCACATGACCCTCCTGGCTGACCTGAAGACCATGGTG
GAGACCAAGAAAGTGACCAGCTCAGGGGTCCTCCTGCTAGATAACTACTCCGACCGCATC
CAGGTCCTCCGGAACATGGTGCACTGTGCCGACCTCAGCAACCCCACCAAGCCGCTGGAG
CTGTACCGCCAGTGGACAGACCGCATCATGGCCGAGTTCTTCCAGCAGGGTGACCGAGAG
CGCGAGCGTGGCATGGAAATCAGCCCCATGTGTGACAAGCACACTGCCTCCGTGGAGAAG
TCTCAGGTGGGTTTTATTGACTACATTGTGCACCCATTGTGGGAGACCTGGGCGGACCTT
GTCCACCCAGATGCCCAGGAGATCTTGGACACTTTGGAGGACAACCGGGACTGGTACTAC
AGCGCCATCCGGCAGAGCCCATCTCCGCCACCCGAGGAGGAGTCAAGGGGGCCAGGCCAC
CCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGAA
ATATCAATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCA
GGAGTCGAGGAAGCTCTGGATGCAACCATAGCCTGGGAGGCATCCCCGGCCCAGGAGTCG
TTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGACA
CAGCAGGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAG
GAATTCGTGGTTGCTGTAAGCCACAGCAGCCCCTCTGCCCTGGCTCTTCAAAGCCCCCTT
CTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCCC
TCCACGGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGT
GCCTGCGCAGGGACATTTGGGGAGGACACATCCGCACTCCCAGCTCCTGGTGGCGGGGGG
TCAGGTGGAGACCCTACCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
L20965

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_2_Locus:
19p13.2

# Metabolic_Enzyme_2_SNPs:
rs1051738; rs2230190; rs2230189; rs7256672; rs3745258; rs4804134; rs2358681; rs10416143; rs7247481; rs7343073; rs1194098; rs11672021; rs1051736; rs3192116; rs35473931; rs35610871; rs3745260; rs3192124; rs3833220; rs7253115; rs12985883; rs3745259; rs34212445; rs2569755; rs35371416; rs12983959; rs2569756; rs2735389; rs5827100; rs11666164; rs10404367; rs12975524; rs34214178; rs35888394; rs10411816; rs34675916; rs12610073; rs35398762; rs34222169; rs33984348; rs34278258; rs35452057; rs12975511; rs34861232; rs12981823; rs12982685; rs1194097; rs4804504; rs35757023; rs12982917; rs35214617; rs34230915; rs4804503; rs35368894; rs12981546; rs12975530; rs3936362; rs35867809; rs2735390; rs10423080; rs2569758; rs2569765; rs12978292; rs2569766; rs12978315; rs2569757; rs2569763; rs12978301; rs2569759; rs2569761; rs12978366; rs2569764; rs2569762; rs12978582; rs2569760; rs12980133; rs35084366; rs12980191; rs12981218; rs35715070; rs34519818; rs35937838; rs10416653; rs11671269; rs2569767; rs2569768; rs4804505; rs8105602

# Metabolic_Enzyme_2_General_References:
8413254; 9677330; 2160582; 7772058; 7888306

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5850

# Metabolic_Enzyme_3_Name:
cGMP-inhibited 3',5'-cyclic phosphodiesterase B

# Metabolic_Enzyme_3_Synonyms:
Cyclic GMP-inhibited phosphodiesterase B; CGI-PDE B; CGIPDE1; CGIP1

# Metabolic_Enzyme_3_Gene_Name:
PDE3B

# Metabolic_Enzyme_3_Protein_Sequence:
>cGMPinhibited 3',5'cyclic phosphodiesterase 
BMRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVEL
RPPPASPQQPRRCSPFCRARLSLGALAAFVLALLLGAEPESWAAGAAWLRTLLSVCSHSL
SPLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDG
DAGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGS
LPSALRPLLSGLVGGAGCLLALGLDHFFQIREAPLHPRLSSAAEEKVPVIRPRRRSSCVS
LGETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLSVLNEA
RNMVSDLLTDPSLPPQVISSLRSISSLMGAFSGSCRPKINPLTPFPGFYPCSEIEDPAEK
GDRKLNKGLNRNSLPTPQLRRSSGTSGLLPVEQSSRWDRNNGKRPHQEFGISSQGCYLNG
PFNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPD
TADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCS
GKSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSL
DLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQ
FMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRI
NHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAP
QAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHF
DFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEF
YEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEED
NDTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEE
EKCKADGNKLQVENSSLPQADEIQVIEEADEEE

# Metabolic_Enzyme_3_Number_of_Residues:
1112

# Metabolic_Enzyme_3_Molecular_Weight:
124335

# Metabolic_Enzyme_3_Theoretical_pI:
5.75

# Metabolic_Enzyme_3_GO_Classification:
Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
May play a role in fat metabolism

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_3_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
88-108
117-137
152-172
192-212
220-240
247-267

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1145302

# Metabolic_Enzyme_3_SwissProt_ID:
PDE3B_HUMAN (Q13370)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
PDE3B

# Metabolic_Enzyme_3_Geneatlas_id:
PDE3B

# Metabolic_Enzyme_3_hgnc_id:
HGNC:8779

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential)

# Metabolic_Enzyme_3_Gene_Sequence:
>3339 bp
ATGAGGAGGGACGAGCGAGACGCCAAAGCCATGCGGTCCCTGCAGCCGCCGGATGGGGCC
GGCTCGCCCCCCGAGAGTCTGAGGAACGGCTACGTGAAGAGCTGCGTGAGCCCCTTGCGG
CAGGACCCTCCGCGCGGCTTCTTCTTCCACCTCTGCCGCTTCTGCAACGTGGAGCTGCGG
CCGCCGCCGGCCTCTCCCCAGCAGCCGCGGCGCTGCTCCCCCTTCTGCCGGGCGCGCCTC
TCGCTGGGCGACCTGGCTGCCTTTGTCCTCGCCCTGCTGCTGGGAGCGGAACCCGAGAGC
TGGGCTGCCGGGGCCGCCTGGCTGCGGACGCTGCTGAGCGTGTGTTCGCACAGCTTGAGC
CCCCTCTTCAGCATCGCCTGTGCCTTCTTCTTCCTCACCTGCTTCCTCACCCGGACCAAG
CGGGGACCCGGCCCGGGCCGGAGCTGCGGCTCCTGGTGGCTGCTGGCGCTGCCCGCCTGC
TGTTACCTGGGGGACTTCTTGGTGTGGCAGTGGTGGTCTTGGCCTTGGGGGGATGGCGAC
GCAGGGTCCGCGGCCCCGCACACGCCCCCGGAGGCGGCAGCGGGCAGGTTGCTGCTGGTG
CTGAGCTGCGTAGGGCTGCTGCTGACGCTCGCGCACCCGCTGCGGCTCCGGCACTGCGTT
CTGGTGCTGCTCCTGGCCAGCTTCGTCTGGTGGGTCTCCTTCACCAGCCTCGGGTCGCTG
CCCTCCGCCCTCAGGCCGCTGCTCTCCGGCCTGGTGGGGGGCGCTGGCTGCCTGCTGGCC
CTGGGGTTGGATCACTTCTTTCAAATCAGGGAAGCGCCTCTTCATCCTCGACTGTCCAGT
GCCGCCGAAGAAAAAGTGCCTGTGATCCGACCCCGGAGGAGGTCCAGCTGCGTGTCGTTA
GGAGAAACTGCAGCCAGTTACTATGGCAGTTGCAAAATATTCAGGAGACCGTCGTTGCCT
TGTATTTCCAGAGAACAGATGATTCTTTGGGATTGGGACTTAAAACAATGGTATAAGCCT
CATTATCAAAATTCTGGAGGTGGAAATGGAGTTGATCTTTCAGTGCTAAATGAGGCTCGC
AATATGGTGTCAGATCTTCTGACTGATCCAAGCCTTCCACCACAAGTCATTTCCTCTCTA
CGGAGTATTAGTAGCTTAATGGGTGCTTTCTCAGGTTCCTGTAGGCCAAAGATTAATCCT
CTCACACCATTTCCTGGATTTTACCCCTGTTCTGAAATAGAGGACCCAGCTGAGAAAGGG
GATAGAAAACTTAACAAGGGACTAAATAGGAATAGTTTGCCAACTCCACAGCTGAGGAGA
AGCTCAGGAACTTCAGGATTGCTACCTGTTGAACAGTCTTCAAGGTGGGATCGTAATAAT
GGCAAAAGGCCTCACCAAGAATTTGGCATTTCAAGTCAAGGATGCTATCTAAATGGGCCT
TTTAATTCAAATCTACTGACTATCCCGAAGCAAAGGTCATCTTCTGTATCACTGACTCAC
CATGTAGGTCTCAGAAGAGCTGGTGTTTTGTCCAGTCTGAGTCCTGTGAATTCTTCCAAC
CATGGACCAGTGTCTACTGGCTCTCTAACTAATCGATCACCCATAGAATTTCCTGATACT
GCTGATTTTCTTAATAAGCCAAGCGTTATCTTGCAGAGATCTCTGGGCAATGCACCTAAT
ACTCCAGATTTTTATCAGCAACTTAGAAATTCTGATAGCAATCTGTGTAACAGCTGTGGA
CATCAAATGCTGAAATATGTTTCAACATCTGAATCAGATGGTACAGATTGCTGCAGTGGA
AAATCAGGTGAAGAAGAAAACATTTTCTCGAAAGAATCATTCAAACTTATGGAAACTCAA
CAAGAAGAGGAAACAGAGAAGAAAGACAGCAGAAAATTATTTCAGGAAGGTGATAAGTGG
CTAACAGAAGAGGCACAGAGTGAACAGCAAACAAATATTGAACAGGAAGTATCACTGGAC
CTGATTTTAGTAGAAGAGTATGACTCATTAATAGAAAAGATGAGCAACTGGAATTTTCCA
ATTTTTGAACTTGTAGAAAAGATGGGAGAGAAATCAGGAAGGATTCTCAGTCAGGTTATG
TATACCTTATTTCAAGACACTGGTTTATTGGAAATATTTAAAATTCCCACTCAACAATTT
ATGAACTATTTTCGTGCATTAGAAAATGGCTATCGAGACATTCCTTATCACAATCGTATA
CATGCCACAGATGTGCTACATGCAGTTTGGTATCTGACAACACGGCCAGTTCCTGGCTTA
CAGCAGATCCACAATGGTTGTGGAACAGGAAATGAAACAGATTCTGATGGTAGAATTAAC
CATGGGCGAATTGCTTATATTTCTTCGAAGAGCTGCTCTAATCCTGATGAGAGTTATGGC
TGCCTGTCTTCAAACATTCCTGCATTAGAATTGATGGCTCTATACGTGGCAGCTGCCATG
CATGATTATGATCACCCAGGGAGGACAAATGCATTTCTAGTGGCTACAAATGCCCCTCAG
GCAGTTTTATACAATGACAGATCTGTTCTGGAAAATCATCATGCTGCGTCAGCTTGGAAT
CTATATCTTTCTCGCCCAGAATACAACTTCCTTCTTCATCTTGATCATGTGGAATTCAAG
CGCTTTCGTTTTTTAGTCATTGAAGCAATCCTTGCTACGGATCTTAAAAAGCATTTTGAT
TTTCTCGCAGAATTCAATGCCAAGGCAAATGATGTAAATAGTAATGGCATAGAATGGAGT
AATGAAAATGATCGCCTCTTGGTATGCCAGGTGTGCATCAAACTGGCAGATATAAATGGC
CCAGCAAAAGTTCGAGACTTGCATTTGAAATGGACAGAAGGCATTGTCAATGAATTTTAT
GAGCAGGGAGATGAAGAAGCAAATCTTGGTCTGCCCATCAGTCCATTCATGGATCGTTCT
TCTCCTCAACTAGCAAAACTCCAAGAATCTTTTATCACCCACATAGTGGGTCCCCTGTGT
AACTCCTATGATGCTGCTGGTTTGCTACCAGGTCAGTGGTTAGAAGCAGAAGAGGATAAT
GATACTGAAAGTGGTGATGATGAAGACGGTGAAGAATTAGATACAGAAGATGAAGAAATG
GAAAACAATCTAAATCCAAAACCACCAAGAAGGAAAAGCAGACGGCGAATATTTTGTCAG
CTAATGCACCACCTCACTGAAAACCACAAGATATGGAAGGAAATCGTAGAGGAAGAAGAA
AAATGTAAAGCTGATGGGAATAAACTGCAGGTGGAGAATTCCTCCTTACCTCAAGCAGAT
GAGATTCAGGTAATTGAAGAGGCAGATGAAGAGGAATAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U38178

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_3_Locus:
11p15.1

# Metabolic_Enzyme_3_SNPs:
rs4757268; rs1247719; rs1247720; rs2060794; rs6486205; rs10832310; rs10832302; rs7952393; rs1403249; rs10219313; rs2177197; rs1007392; rs2167453; rs1037379; rs7942142; rs7117383; rs10766195; rs10832312; rs10832297; rs7117967; rs4144487; rs7109368; rs2350239; rs1879888; rs7947041; rs10734227; rs10732460; rs4757261; rs10832296; rs1403248; rs1879890; rs10832299; rs7102741; rs10741656; rs4757262; rs16930498; rs11023310; rs11023315; rs10128681; rs11023294; rs731042; rs4344519; rs10832309; rs7113970; rs11821089; rs11493371; rs10832306; rs7116978; rs10832294; rs7103015; rs12577507; rs10430883; rs3206554; rs1879889; rs12419818; rs7119073; rs11826363; rs9971395; rs1496167; rs7125781; rs1451677; rs1037378; rs10741653; rs1451678; rs16930448; rs11023350; rs7939648; rs12416696; rs11827089; rs10832304; rs11023322; rs1542291; rs12283049; rs11023332; rs7944633; rs10766192; rs3740823; rs7938266; rs16930437; rs6486201; rs7118016; rs2349789; rs12295371; rs7483120; rs10160291; rs7108484; rs11023333; rs7102037; rs4757266; rs12788030; rs2122942; rs12575877; rs7119320; rs11600656; rs11600815; rs10832311; rs2349790; rs10832298; rs11023298; rs10741655; rs7109892; rs6486202; rs16930520; rs994953; rs10832291; rs11023314; rs12577302; rs7101755; rs1812422; rs12226716; rs11605452; rs1839834; rs11023307; rs11023293; rs4757264; rs10832303; rs2122941; rs11023338; rs7108485; rs11023312; rs7120890; rs7937511; rs11023341; rs10832308; rs7108996; rs10832290; rs11600054; rs10832307; rs2349792; rs12577984; rs16930516; rs6486203; rs10766189; rs11023301; rs10832289; rs1996845; rs11827484; rs10832293; rs11602976; rs17409116; rs6486200; rs11607383; rs2350240; rs11828362; rs12281928; rs7114131; rs4356261; rs11023295; rs4373971; rs16930500; rs7108085; rs1597689; rs7941356; rs17487995; rs7124234; rs10734226; rs16930417; rs11822044; rs11825595; rs12419657; rs7109324; rs11023366; rs11023299; rs12275997; rs10832301; rs2349793; rs4757269; rs10741654; rs11820798; rs7941282; rs17847308; rs17847305; rs3758762; rs35435795; rs12797647; rs11023300; rs28553464; rs5789854; rs11454337; rs34804824; rs5789848; rs11333119; rs12275731; rs12788403; rs11023317; rs11355203; rs11023367; rs12281621; rs11023323; rs11023306; rs10676187; rs35362268; rs11820859; rs11023348; rs12788556; rs1011649; rs34241017; rs34596529; rs34786278; rs34303741; rs35055334; rs7103459; rs11023331; rs35327317; rs10430881; rs11828911; rs4294593; rs3059191; rs11023352; rs36116790; rs11023364; rs34059683; rs2088266; rs11023343; rs12226160; rs34954349; rs34189385; rs35321904; rs11023360; rs1357333; rs12797253; rs34662834; rs10832292; rs35712723; rs11023327; rs35949086; rs10766193; rs11821380; rs34687016; rs34466563; rs34654813; rs2060795; rs34154564; rs1451675; rs10710184; rs35606970; rs5789853; rs11606533; rs34360743; rs34041254; rs35440758; rs34572489; rs10766194; rs34555721; rs11023356; rs12787596; rs35283294; rs3834439; rs34905422; rs11023325; rs7938369; rs12795812; rs1065539; rs35596025; rs10832295; rs5789851; rs11510168; rs11309629; rs35166452; rs35021133; rs12576750; rs36115886; rs35568417; rs12270174; rs12574319; rs11023320; rs11023349; rs35024500; rs34706114; rs35887203; rs34644033; rs28825106; rs9735337; rs11602179; rs36072943; rs10047458; rs10534250; rs4757263; rs28689801; rs28523396; rs11023344; rs12360598; rs11601586; rs10666771; rs35969978; rs35595332; rs10766190; rs35637093; rs7483046; rs12362671; rs12576508; rs4367976; rs4757267; rs5789846; rs7109801; rs11023351; rs36006283; rs11023359; rs34641133; rs34945945; rs12803117; rs11023330; rs11529568; rs4492851; rs4589330; rs34954991; rs12788363; rs12797543; rs11023368; rs5010969; rs7931505; rs1996844; rs4275651; rs12290200; rs35913217; rs11023296; rs11023326; rs34552938; rs12797650; rs7928396; rs34175247; rs12808918; rs11419989; rs12281550; rs36114974; rs5789852; rs11023361; rs34924724; rs34083172; rs35572071; rs11023319; rs12785496; rs12575421; rs7925742; rs11023329; rs2204135; rs2349791; rs10590358; rs35494855; rs11023321; rs4281505; rs11600046; rs12366054; rs34569843; rs11023335; rs35823303; rs10430882; rs11408185; rs3834440; rs35648670; rs7924479; rs34862859; rs35211975; rs35820244; rs34813284; rs4575307; rs35895679; rs4356262; rs12795858; rs35700152; rs3758763; rs11023354; rs11023324; rs34139819; rs5789847; rs11023365; rs11023345; rs12795794; rs11023313; rs11023309; rs11529569; rs35730548; rs1115248; rs10626907; rs11023358; rs35212472; rs12224911; rs35104590; rs35926137; rs11023308; rs12362090; rs4283008; rs11023337; rs34129246; rs11023342; rs11023357; rs4477466; rs11023311; rs12792463; rs35291929; rs4757265; rs34509621; rs34966272; rs12417206; rs12805859; rs11023347; rs7342234; rs11820820; rs35577691; rs11023362; rs35185862; rs36069287; rs34106565; rs10555077; rs11023316; rs11023305; rs7396747; rs35012534; rs11023318; rs34974264; rs35972023; rs11023353; rs34427806; rs7127312; rs1376692; rs12418776; rs12419521; rs34365112; rs11313201; rs12364493; rs34567179; rs12362122; rs7944149; rs12801860; rs10610728; rs1451676; rs12361595; rs11023292; rs11023336; rs7945265; rs5789850; rs11023363; rs35483173; rs34959387; rs35827559; rs12788203; rs35535425; rs11604119; rs35573904; rs1349535; rs12576554; rs11023346; rs11421967; rs4281506; rs36089212; rs7105853; rs35098776; rs35938275; rs35535548; rs1056584; rs10766188; rs10832288; rs11023291; rs11023302; rs11023304; rs11023370; rs11023371; rs11600307; rs11820826; rs12417788; rs1270458; rs12796659; rs1533852; rs1868997; rs1879891; rs2291781; rs6486207; rs7104901; rs7109770

# Metabolic_Enzyme_3_General_References:
8884271; 8921398

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5888

# Metabolic_Enzyme_4_Name:
High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

# Metabolic_Enzyme_4_Synonyms:
Not Available

# Metabolic_Enzyme_4_Gene_Name:
PDE9A

# Metabolic_Enzyme_4_Protein_Sequence:
>Highaffinity cGMPspecific 3',5'cyclic phosphodiesterase 9
AMGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDA
MVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRR
EGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVAN
HLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRD
VPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWL
FCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGY
NNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITL
ILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDC
LLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIM
LQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA

# Metabolic_Enzyme_4_Number_of_Residues:
593

# Metabolic_Enzyme_4_Molecular_Weight:
68493

# Metabolic_Enzyme_4_Theoretical_pI:
6.10

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase has a high affinity for cGMP

# Metabolic_Enzyme_4_Pathway:
Not Available

# Metabolic_Enzyme_4_Reaction:
guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.1.4.35

# Metabolic_Enzyme_4_GenBank_ID_Protein:
3242777

# Metabolic_Enzyme_4_SwissProt_ID:
PDE9A_HUMAN (O76083)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
PDE9A

# Metabolic_Enzyme_4_Geneatlas_id:
PDE9A

# Metabolic_Enzyme_4_hgnc_id:
HGNC:8795

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_4_Gene_Sequence:
>1782 bp
ATGGGATCCGGCTCCTCCAGCTACCGGCCCAAGGCCATCTACCTGGACATCGATGGACGC
ATTCAGAAGGTAATCTTCAGCAAGTACTGCAACTCCAGCGACATCATGGACCTGTTCTGC
ATCGCCACCGGCCTGCCTCGGAACACGACCATCTCCCTGCTGACCACCGACGACGCCATG
GTCTCCATCGACCCCACCATGCCCGCGAATTCAGAACGCACTCCGTACAAAGTGAGACCT
GTGGCCATCAAGCAACTCTCCGCTGGTGTCGAGGACAAGAGAACCACAAGCCGTGGCCAG
TCTGCTGAGAGACCACTGAGGGACAGACGGGTTGTGGGCCTGGAGCAGCCCCGGAGGGAA
GGAGCATTTGAAAGTGGACAGGTAGAGCCCAGGCCCAGAGAGCCCCAGGGCTGCTACCAG
GAAGGCCAGCGCATCCCTCCAGAGAGAGAAGAATTAATCCAGAGCGTGCTGGCGCAGGTT
GCAGAGCAGTTCTCAAGAGCATTCAAAATCAATGAACTGAAAGCTGAAGTTGCAAATCAC
TTGGCTGTCCTAGAGAAACGCGTGGAATTGGAAGGACTAAAAGTGGTGGAGATTGAGAAA
TGCAAGAGTGACATTAAGAAGATGAGGGAGGAGCTGGCGGCCAGAAGCAGCAGGACCAAC
TGCCCCTGTAAGTACAGTTTTTTGGATAACCACAAGAAGTTGACTCCTCGACGCGATGTT
CCCACTTACCCCAAGTACCTGCTCTCTCCAGAGACCATCGAGGCCCTGCGGAAGCCGACC
TTTGACGTCTGGCTTTGGGAGCCCAATGAGATGCTGAGCTGCCTGGAGCACATGTACCAC
GACCTCGGGCTGGTCAGGGACTTCAGCATCAACCCTGTCACCCTCAGGAGGTGGCTGTTC
TGTGTCCACGACAACTACAGAAACAACCCCTTCCACAACTTCCGGCACTGCTTCTGCGTG
GCCCAGATGATGTACAGCATGGTCTGGCTCTGCAGTCTCCAGGAGAAGTTCTCACAAACG
GATATCCTGATCCTAATGACAGCGGCCATCTGCCACGATCTGGACCATCCCGGCTACAAC
AACACGTACCAGATCAATGCCCGCACAGAGCTGGCGGTCCGCTACAATGACATCTCACCG
CTGGAGAACCACCACTGCGCCGTGGCCTTCCAGATCCTCGCCGAGCCTGAGTGCAACATC
TTCTCCAACATCCCACCTGATGGGTTCAAGCAGATCCGACAGGGAATGATCACATTAATC
TTGGCCACTGACATGGCAAGACATGCAGAAATTATGGATTCTTTCAAAGAGAAAATGGAG
AATTTTGACTACAGCAACGAGGAGCACATGACCCTGCTGAAGATGATTTTGATAAAATGC
TGTGATATCTCTAACGAGGTCCGTCCAATGGAAGTCGCAGAGCCTTGGGTGGACTGTTTA
TTAGAGGAATATTTTATGCAGAGCGACCGTGAGAAGTCAGAAGGCCTTCCTGTGGCACCG
TTCATGGACCGAGACAAAGTGACCAAGGCCACAGCCCAGATTGGGTTCATCAAGTTTGTC
CTGATCCCAATGTTTGAAACAGTGACCAAGCTCTTCCCCATGGTTGAGGAGATCATGCTG
CAGCCACTTTGGGAATCCCGAGATCGCTACGAGGAGCTGAAGCGGATAGATGACGCCATG
AAAGAGTTACAGAAGAAGACTGACAGCTTGACGTCTGGGGCCACCGAGAAGTCCAGAGAG
AGAAGCAGAGATGTGAAAAACAGTGAAGGAGACTGTGCCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF048837

# Metabolic_Enzyme_4_Chromosome_Location:
Not Available

# Metabolic_Enzyme_4_Locus:
Not Available

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
9624146; 9856478; 12565835; 14527714; 10830953

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5881

# Metabolic_Enzyme_5_Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B

# Metabolic_Enzyme_5_Synonyms:
DPDE4; PDE32

# Metabolic_Enzyme_5_Gene_Name:
PDE4B

# Metabolic_Enzyme_5_Protein_Sequence:
>cAMPspecific 3',5'cyclic phosphodiesterase 4
BMKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQ
SERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLV
LHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSV
RNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTY
RSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKK
KKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYS
HNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTH
VLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH
LAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVT
SSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGME
ISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQS
PSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSL
GETDIDIATEDKSPVDT

# Metabolic_Enzyme_5_Number_of_Residues:
736

# Metabolic_Enzyme_5_Molecular_Weight:
83344

# Metabolic_Enzyme_5_Theoretical_pI:
4.89

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents

# Metabolic_Enzyme_5_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_5_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_5_GenBank_ID_Protein:
347122

# Metabolic_Enzyme_5_SwissProt_ID:
PDE4B_HUMAN (Q07343)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
PDE4B

# Metabolic_Enzyme_5_Geneatlas_id:
PDE4B

# Metabolic_Enzyme_5_hgnc_id:
HGNC:8781

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_5_Gene_Sequence:
>2211 bp
ATGAAGAAAAGCAGGAGTGTGATGACGGTGATGGCTGATGATAATGTTAAAGATTATTTT
GAATGTAGCTTGAGTAAATCCTACAGTTCTTCCAGTAACACACTTGGGATCGACCTCTGG
AGAGGGAGAAGGTGTTGCTCAGGAAACTTACAGTTACCACCACTGTCTCAAAGACAGAGT
GAAAGGGCAAGGACTCCTGAGGGAGATGGTATTTCCAGGCCGACCACACTGCCTTTGACA
ACGCTTCCAAGCATTGCTATTACAACTGTAAGCCAGGAGTGCTTTGATGTGGAAAATGGC
CCTTCCCCAGGTCGGAGTCCACTGGATCCCCAGGCCAGCTCTTCCGCTGGGCTGGTACTT
CACGCCACCTTTCCTGGGCACAGCCAGCGCAGAGAGTCATTTCTCTACAGATCAGACAGC
GACTATGACTTGTCACCAAAGGCGATGTCGAGAAACTCTTCTCTTCCAAGCGAGCAACAC
GGCGATGACTTGATTGTAACTCCTTTTGCCCAGGTCCTTGCCAGCTTGCGAAGTGTGAGA
AACAACTTCACTATACTGACAAACCTTCATGGTACATCTAACAAGAGGTCCCCAGCTGCT
AGTCAGCCTCCTGTCTCCAGAGTCAACCCACAAGAAGAATCTTATCAAAAATTAGCAATG
GAAACGCTGGAGGAATTAGACTGGTGTTTAGACCAGCTAGAGACCATACAGACCTACCGG
TCTGTCAGTGAGATGGCTTCTAACAAGTTCAAAAGAATGCTGAACCGGGAGCTGACACAC
CTCTCAGAGATGAGCCGATCAGGGAACCAGGTGTCTGAATACATTTCAAATACTTTCTTA
GACAAGCAGAATGATGTGGAGATCCCATCTCCTACCCAGAAAGACAGGGAGAAAAAGAAA
AAGCAGCAGCTCATGACCCAGATAAGTGGAGTGAAGAAATTAATGCATAGTTCAAGCCTA
AACAATACAAGCATCTCACGCTTTGGAGTCAACACTGAAAATGAAGATCACCTGGCCAAG
GAGCTGGAAGACCTGAACAAATGGGGTCTTAACATCTTTAATGTGGCTGGATATTCTCAC
AATAGACCCCTAACATGCATCATGTATGCTATATTCCAGGAAAGAGACCTCCTAAAGACA
TTCAGAATCTCATCTGACACATTTATAACCTACATGATGACTTTAGAAGACCATTACCAT
TCTGACGTGGCATATCACAACAGCCTGCACGCTGCTGATGTAGCCCAGTCGACCCATGTT
CTCCTTTCTACACCAGCATTAGACGCTGTCTTCACAGATTTGGAGATCCTGGCTGCCATT
TTTGCAGCTGCCATCCATGACGTTGATCATCCTGGAGTCTCCAATCAGTTTCTCATCAAC
ACAAATTCAGAACTTGCTTTGATGTATAATGATGAATCTGTGTTGGAAAATCATCACCTT
GCTGTGGGTTTCAAACTGCTGCAAGAAGAACACTGTGACATCTTCATGAATCTCACCAAG
AAGCAGCGTCAGACACTCAGGAAGATGGTTATTGACATGGTGTTAGCAACTGATATGTCT
AAACATATGAGCCTGCTGGCAGACCTGAAGACAATGGTAGAAACGAAGAAAGTTACAAGT
TCAGGCGTTCTTCTCCTAGACAACTATACCGATCGCATTCAGGTCCTTCGCAACATGGTA
CACTGTGCAGACCTGAGCAACCCCACCAAGTCCTTGGAATTGTATCGGCAATGGACAGAC
CGCATCATGGAGGAATTTTTCCAGCAGGGAGACAAAGAGCGGGAGAGGGGAATGGAAATT
AGCCCAATGTGTGATAAACACACAGCTTCTGTGGAAAAATCCCAGGTTGGTTTCATCGAC
TACATTGTCCATCCATTGTGGGAGACATGGGCAGATTTGGTACAGCCTGATGCTCAGGAC
ATTCTCGATACCTTAGAAGATAACAGGAACTGGTATCAGAGCATGATACCTCAAAGTCCC
TCACCACCACTGGACGAGCAGAACAGGGACTGCCAGGGTCTGATGGAGAAGTTTCAGTTT
GAACTGACTCTCGATGAGGAAGATTCTGAAGGACCTGAGAAGGAGGGAGAGGGACACAGC
TATTTCAGCAGCACAAAGACGCTTTGTGTGATTGATCCAGAAAACAGAGATTCCCTGGGA
GAGACTGACATAGACATTGCAACAGAAGACAAGTCCCCCGTGGATACATAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
L20966

# Metabolic_Enzyme_5_Chromosome_Location:
Not Available

# Metabolic_Enzyme_5_Locus:
Not Available

# Metabolic_Enzyme_5_SNPs:
Not Available

# Metabolic_Enzyme_5_General_References:
8413254; 9371714; 8384210

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5977

# Metabolic_Enzyme_6_Name:
Adenylate cyclase type 7

# Metabolic_Enzyme_6_Synonyms:
Adenylate cyclase type VII; ATP pyrophosphate-lyase 7; Adenylyl cyclase 7

# Metabolic_Enzyme_6_Gene_Name:
ADCY7

# Metabolic_Enzyme_6_Protein_Sequence:
>Adenylate cyclase type 7
MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPS
RHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAA
CAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQL
LANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAH
ISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKEL
VVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQ
VREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT
LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRA
SVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRS
EDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACA
SLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISER
VETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLP
YYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKP
NGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFET
MENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKE
GLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAH
IGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVAS
RMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN


# Metabolic_Enzyme_6_Number_of_Residues:
1080

# Metabolic_Enzyme_6_Molecular_Weight:
120310

# Metabolic_Enzyme_6_Theoretical_pI:
8.16

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  cyclase activity
Function:  adenylate cyclase activity
Function:  catalytic activity
Function:  lyase activity
Function:  phosphorus-oxygen lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  cyclic nucleotide biosynthesis
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Metabolic_Enzyme_6_General_Function:
Signal transduction mechanisms 

# Metabolic_Enzyme_6_Specific_Function:
This is a membrane-bound, calcium-inhibitable adenylyl cyclase

# Metabolic_Enzyme_6_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_6_Reaction:
ATP = 3',5'-cyclic AMP + diphosphate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF06327:DUF1053;
PF00211:Guanylate_cyc

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
34-54
63-83
95-117
122-142
147-167
176-196
595-615
620-640
669-688
718-737
746-773
794-814

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 4.6.1.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
40788941

# Metabolic_Enzyme_6_SwissProt_ID:
ADCY7_HUMAN (P51828)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ADCY7

# Metabolic_Enzyme_6_Geneatlas_id:
ADCY7

# Metabolic_Enzyme_6_hgnc_id:
HGNC:238

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Membrane; multi-pass membrane protein

# Metabolic_Enzyme_6_Gene_Sequence:
>3267 bp
CGACACGCGTGCCAAGGGTGGAGGATGCCAGCCAAGGGGCGCTACTTCCTCAACGAGGGC
GAGGAGGGCCCTGACCAAGATGCGCTCTACGAGAAGTACCAGCTCACCAGCCAGCATGGG
CCGCTGCTGCTCACGCTCCTGCTGGTGGCCGCCACTGCCTGCGTGGCCCTCATCATCATT
GCCTTCAGCCAGGGGGACCCCTCCAGACACCAGGCCATTCTGGGCATGGCGTTCCTGGTG
CTGGCGGTGTTTGCGGCCCTCTCTGTGCTGATGTACGTCGAGTGTCTCCTGCGGCGCTGG
CTCAGGGCCTTGGCGCTGCTCACCTGGGCCTGCTTGGTGGCGCTGGGCTATGTGCTGGTG
TTCGACGCATGGACAAAGGCGGCCTGTGCGTGGGAGCAGGTGCCCTTCTTCCTGTTCATT
GTCTTCGTGGTGTACACACTACTGCCCTTCAGCATGCGGGGCGCTGTCGCCGTTGGGGCC
GTCTCCACTGCCTCCCACCTCCTGGTGCTCGGTTCTTTGATGGGAGGCTTCACGACACCC
AGTGTCCGGGTGGGGCTGCAGCTGCTGGCCAACGCAGTCATCTTCCTGTGTGGGAACCTG
ACAGGCGCCTTCCACAAGCACCAAATGCAGGATGCGTCCCGGGACCTCTTCACCTACACT
GTGAAGTGCATCCAGATCCGCCGGAAGCTGCGCATCGAGAAGCGCCAGCAGGAGAACCTG
CTGCTGTCAGTGCTTCCGGCCCACATCTCCATGGGCATGAAGCTGGCCATCATCGAACGG
CTCAAGGAGCATGGTGACCGTCGCTGCATGCCTGACAACAACTTCCACAGCCTCTACGTC
AAGAGGCACCAGAATGTCAGCATCCTCTATGCGGACATCGTGGGCTTCACGCAGCTGGCC
AGCGACTGTTCTCCCAAGGAGCTGGTGGTGGTGCTGAATGAGCTCTTTGGCAAGTTCGAC
CAGATCGCCAAGGCCAACGAGTGCATGCGAATCAAGATCCTCGGCGACTGCTACTACTGT
GTATCGGGCCTGCCCGTGTCGCTGCCTACCCACGCCCGGAACTGCGTGAAGATGGGGCTG
GACATGTGCCAGGCCATCAAGCAGGTGCGGGAGGCCACGGGCGTGGACATCAACATGCGT
GTGGGCATACACTCGGGGAATGTGCTGTGCGGGGTCATCGGGCTGCGCAAGTGGCAGTAT
GACGTGTGGTCCCACGACGTGTCCCTGGCCAACCGGATGGAGGCAGCCGGAGTACCCGGC
CGGGTGCACATCACGGAGGCCACGCTAAAGCACCTGGACAAGGCGTACGAGGTGGAGGAT
GGGCACGGGCAGCAGCGGGACCCCTACCTCAAGGAGATGAACATCCGCACCTACCTGGTC
ATCGACCCCCGGAGCCAGCAGCCACCCCCGCCCAGCCAACACCTCCCCAGGCCCAAGGGG
GACGCGGCCCTGAAGATGCGGGCGTCAGTGCGCATGACCCGGTACCTCGAGTCCTGGGGG
GCGGCACGGCCCTTTGCACATCTCAACCACCGTGAGAGCGTGAGCAGTGGTGAGACCCAC
GTCCCCAACGGGCGGAGGCCTAAGAGCGTTCCCCAGCGCCACCGCCGGACCCCAGACAGA
AGCATGTCCCCCAAGGGGCGGTCGGAGGATGACTCGTACGATGACGAGATGCTGTCAGCC
ATTGAGGGGCTCAGCTCCACGAGGCCCTGCTGCTCCAAGTCCGATGACTTCTACACCTTT
GGGTCCATCTTCCTGGAGAAGGGCTTTGAGCGCGAGTACCGCCTGGCACCCATCCCCCGG
GCCCGCCACGACTTTGCCTGCGCCAGCCTGATCTTCGTCTGCATCCTGCTCGTCCATGTC
CTGCTCATGCCCAGGACGGCGGCACTGGGTGTGTCCTTCGGGCTGGTGGCCTGTGTACTG
GGGCTGGTGCTGGGCCTGTGCTTTGCCACCAAGTTCTCGAGGTGCTGCCCAGCTCGGGGG
ACGCTCTGCACTATCTCTGAGAGGGTGGAGACACAGCCCCTGCTGAGGCTGACCCTGGCC
GTCCTGACCATCGGCAGCCTGCTCACTGTGGCCATCATCAACCTGCCCCTGATGCCTTTC
CAAGTTCCAGAGCTGCCTGTTGGCAATGAGACAGGCCTACTGGCCGCGAGCAGCAAGACA
AGAGCCCTGTGTGAGCCCCTCCCGTACTACACCTGCAGCTGTGTCCTGGGCTTCATCGCC
TGCTCGGTCTTCCTGAGGATGAGCCTGGAGCCAAAGGTTGTGCTGCTGACAGTGGCCCTG
GTGGCCTACCTGGTGCTCTTCAACCTCTCCCCATGCTGGCAGTGGGACTGCTGCGGCCAA
GGCCTGGGCAACCTCACCAAGCCCAACGGCACCACCAGTGGCACCCCTAGCTGTTCCTGG
AAGGACCTGAAGACCATGACCAATTTCTACCTGGTCCTGTTCTACATCACCCTGCTTACA
CTCTCCAGACAGATTGACTATTACTGCCGCTTGGACTGCCTATGGAAGAAGAAGTTCAAG
AAGGAGCACGAGGAGTTTGAGACCATGGAGAACGTGAACCGCCTTCTTCTGGAGAACGTC
CTGCCAGCCCACGTGGCTGCCCACTTTATCGGTGACAAGTTAAACGAGGACTGGTACCAT
CAGTCCTATGACTGCGTCTGTGTCATGTTTGCCTCCGTGCCGGACTTCAAAGTGTTCTAC
ACAGAGTGCGATGTCAACAAAGAAGGGCTGGAGTGCCTACGCCTGCTCAATGAGATCATT
GCCGACTTCGACGAGCTCCTACTGAAGCCCAAGTTCAGCGGCGTGGAGAAGATCAAGACC
ATCGGCAGCACGTACATGGCAGCTGCAGGGCTCAGCGTCGCCTCAGGGCACGAGAACCAG
GAGCTGGAGCGGCAGCATGCCCACATTGGTGTCATGGTGGAGTTCAGCATCGCCCTGATG
AGTAAGCTGGACGGCATCAACAGGCACTCCTTCAACTCCTTCCGCCTCCGCGTCGGCATA
AACCATGGGCCTGTGATTGCTGGAGTGATTGGGGCCCGAAAACCTCAGTATGACATCTGG
GGAAACACTGTCAATGTGGCCAGCCGAATGGAAAGCACTGGAGAACTTGGGAAAATCCAG
GTTACCGAGGAGACCTGCACCATCCTCCAGGGCCTCGGGTACTCTTGTGAATGCCGTGGC
CTGATCAACGTCAAAGGCAAAGGCGAGCTGAGGACTTACTTTGTCTGTACGGACACTGCC
AAGTTTCAGGGGCTGGGGCTGAACTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
D25538

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_6_Locus:
16q12-q13

# Metabolic_Enzyme_6_SNPs:
rs17289102; rs11861332; rs1064448; rs1872691; rs11644926; rs1540624; rs2302681; rs8052384; rs9939322; rs4785211; rs9936021; rs4785403; rs8061123; rs9926131; rs7191958; rs4785210; rs4785402; rs3813755; rs729229; rs2302712; rs11649380; rs9924714; rs8045659; rs8049122; rs2302680; rs7193839; rs11648839; rs7193875; rs2302717; rs2302715; rs12445243; rs11859417; rs728962; rs2302716; rs11861597; rs7202127; rs7186882; rs12444679; rs8056293; rs3833062; rs2302679; rs9927261; rs8060642; rs4082435; rs3826173; rs3892156; rs3760012; rs3760011; rs28514808; rs7359472; rs2230664; rs1064447; rs8051594; rs35787328; rs10589177; rs9940992; rs4785407; rs12918980; rs12444266; rs7500891; rs5816686; rs35969283; rs34860956; rs34493825; rs9937781; rs35262781; rs2302678; rs13332825; rs12932721; rs34996336; rs2302714; rs11640409; rs12932722; rs16948389; rs34039653; rs28510819; rs28432797; rs3841348; rs3214383; rs3815562; rs35078746; rs34191947; rs11403746; rs4502213; rs34381393; rs7197662; rs35284914; rs28403987; rs2302713; rs12919306; rs35003370; rs35732926; rs35829985; rs34216705; rs11352304; rs10577557; rs12444236; rs12924307; rs12598249; rs11417859; rs12443620; rs8048743; rs34009001; rs34686094; rs8053067; rs1078151; rs11644043; rs11645133; rs11649621; rs11860192; rs17216076; rs1872688; rs34176129; rs3760013; rs3760014; rs4497684; rs4785401; rs4785408; rs7184476; rs7184802; rs7196135; rs7204026; rs751127; rs8046783; rs8057103; rs8061808; rs9922362; rs9926720; rs9937029; rs9940619

# Metabolic_Enzyme_6_General_References:
7584026

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5978

# Metabolic_Enzyme_7_Name:
Adenylate cyclase type 4

# Metabolic_Enzyme_7_Synonyms:
Adenylate cyclase type IV; ATP pyrophosphate-lyase 4; Adenylyl cyclase 4

# Metabolic_Enzyme_7_Gene_Name:
ADCY4

# Metabolic_Enzyme_7_Protein_Sequence:
>Adenylate cyclase type 4
MARLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPS
FLTTVLCALGGFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSAWDQV
SYFLFVIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVL
FLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMK
AEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE
LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATG
VDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG
AYAVEDAGMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGLKMRPSLLMTR
YLESWGAAKPFAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRTPRGLDDELDTGDAK
FFQVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFI
IQMLVTNRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRP
GLRIALGTATILLVFAMAITSLFFFPTSSDCPFQAPNVSSMISNLSWELPGSLPLISVPY
SMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSECLIVRLYLGPLDS
RPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRL
LLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLR
LLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMV
EFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMEST
GVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGPPSATLG

# Metabolic_Enzyme_7_Number_of_Residues:
1077

# Metabolic_Enzyme_7_Molecular_Weight:
119796

# Metabolic_Enzyme_7_Theoretical_pI:
7.50

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  cyclase activity
Function:  adenylate cyclase activity
Function:  catalytic activity
Function:  lyase activity
Function:  phosphorus-oxygen lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  cyclic nucleotide biosynthesis
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Metabolic_Enzyme_7_General_Function:
Signal transduction mechanisms 

# Metabolic_Enzyme_7_Specific_Function:
This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

# Metabolic_Enzyme_7_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_7_Reaction:
ATP = 3',5'-cyclic AMP + diphosphate

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF06327:DUF1053;
PF00211:Guanylate_cyc

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
29-50
61-80
94-117
120-138
141-162
170-190
586-607
611-633
664-687
715-736
744-764
791-807

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 4.6.1.1

# Metabolic_Enzyme_7_GenBank_ID_Protein:
22212709

# Metabolic_Enzyme_7_SwissProt_ID:
ADCY4_HUMAN (Q8NFM4)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
ADCY4

# Metabolic_Enzyme_7_Geneatlas_id:
ADCY4

# Metabolic_Enzyme_7_hgnc_id:
HGNC:235

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Membrane; multi-pass membrane protein

# Metabolic_Enzyme_7_Gene_Sequence:
>3234 bp
ATGGCCCGCCTCTTCAGCCCCCGGCCGCCCCCCAGCGAAGACCTCTTCTACGAGACCTAC
TACAGCCTGAGCCAGCAGTACCCGCTGCTGCTGCTGCTGCTGGGGATCGTGCTCTGTGCG
CTCGCGGCGCTGCTCGCAGTGGCCTGGGCCAGCGGCAGGGAGCTGACCTCAGACCCGAGC
TTCCTGACCACTGTGCTGTGCGCGCTGGGCGGCTTCTCGCTGCTGCTGGGCCTCGCTTCC
CGGGAGCAGCGACTGCAGCGCTGGACGCGTCCCCTGTCCGGCTTGGTATGGGTCGCGCTG
CTAGCGCTAGGCCACGCCTTCCTGTTCACCGGGGGCGTGGTGAGCGCCTGGGACCAGGTG
TCCTATTTTCTCTTCGTCATCTTCACGGCGTATGCCATGCTGCCCTTGGGCATGCGGGAC
GCCGCCGTCGCGGGCCTCGCCTCCTCACTCTCGCATCTGCTGGTCCTCGGGCTGTATCTT
GGGCCACAGCCGGACTCACGGCCTGCACTGCTGCCGCAGTTGGCAGCAAACGCAGTGCTG
TTCCTGTGCGGGAACGTGGCAGGAGTGTACCACAAGGCGCTGATGGAGCGCGCCCTGCGG
GCCACGTTCCGGGAGGCACTCAGCTCCCTGCACTCACGCCGGCGGCTGGACACCGAGAAG
AAGCACCAGGAACACCTTCTCTTGTCCATCCTTCCTGCCTACCTGGCCCGAGAGATGAAG
GCAGAGATCATGGCACGGCTGCAGGCAGGACAGGGGTCACGGCCAGAGAGCACTAACAAT
TTCCACAGCCTCTATGTCAAGAGGCACCAGGGAGTCAGCGTGCTGTATGCTGACATCGTG
GGCTTCACGCGGCTGGCCAGCGAGTGTTCCCCTAAGGAGCTGGTGCTCATGCTCAATGAG
CTCTTTGGCAAGTTCGACCAGATTGCCAAGGAGCATGAATGCATGCGGATCAAGATCCTG
GGGGACTGTTACTACTGTGTCTCTGGGCTGCCACTCTCACTGCCAGACCATGCCATCAAC
TGCGTGCGCATGGGCCTGGACATGTGCCGGGCCATCAGGAAACTGCGGGCAGCCACTGGC
GTGGACATCAACATGCGTGTGGGCGTGCACTCAGGCAGCGTACTGTGTGGAGTCATCGGG
CTGCAGAAGTGGCAGTACGACGTTTGGTCACATGATGTCACACTGGCTAACCACATGGAG
GCAGGCGGTGTACCAGGGCGAGTGCACATCACAGGGGCTACCCTGGCCCTGCTGGCAGGG
GCTTATGCTGTGGAGGACGCAGGCATGGAGCATCGGGACCCCTACCTTCGGGAGCTAGGG
GAGCCTACCTATCTGGTCATCGATCCACGGGCAGAGGAGGAGGATGAGAAGGGCACTGCA
GGAGGCTTGCTGTCCTCGCTTGAGGGCCTCAAGATGCGTCCATCACTGCTGATGACCCGT
TACCTGGAGTCCTGGGGCGCAGCCAAGCCTTTTGCCCACCTGAGCCACGGAGACAGCCCT
GTGTCCACCTCCACCCCTCTCCCGGAGAAGACCCTGGCTTCCTTCAGCACCCAGTGGAGC
CTGGATCGGAGCCGTACCCCCCGGGGACTAGATGATGAACTGGACACCGGGGATGCCAAG
TTCTTCCAGGTCATTGAGCAGCTCAACTCGCAGAAACAGTGGAAGCAGTCGAAGGACTTC
AACCCACTGACACTGTACTTCAGAGAGAAGGAGATGGAGAAAGAGTACCGACTCTCTGCA
ATCCCCGCCTTCAAATACTATGAAGCCTGCACCTTCCTGGTTTTTCTCTCCAACTTCATC
ATCCAGATGCTAGTGACAAACAGGCCCCCAGCTCTGGCCATCACGTATAGCATCACCTTC
CTCCTCTTCCTCCTCATCCTTTTTGTCTGCTTCTCAGAGGACCTGATGAGGTGTGTCCTG
AAAGGCCCCAAGATGCTGCACTGGCTGCCTGCACTGTCTGGCCTGGTGGCCACACGACCA
GGACTGAGAATAGCCTTGGGCACCGCCACCATCCTCCTTGTCTTTGCCATGGCCATTACC
AGCCTGTTCTTCTTCCCAACATCATCAGACTGCCCTTTCCAAGCTCCCAATGTGTCCTCC
ATGATTTCCAACCTCTCCTGGGAGCTCCCTGGGTCTCTGCCTCTCATCAGTGTCCCATAC
TCCATGCACTGCTGCACGCTGGGCTTCCTCTCCTGCTCCCTCTTTCTGCACATGAGCTTC
GAGCTGAAGCTGCTGCTGCTCCTGCTGTGGCTGGCGGCATCCTGCTCCCTCTTCCTGCAC
TCCCATGCCTGGCTGTCGGAATGCCTCATCGTCCGCCTCTATCTGGGCCCCTTGGACTCC
AGGCCCGGAGTGCTGAAGGAGCCCAAACTGATGGGTGCTATCTCCTTCTTCATCTTCTTC
TTCACCCTCCTTGTCCTGGCTCGCCAGAATGAGTACTACTGCCGCCTGGACTTCCTGTGG
AAGAAGAAGCTGAGGCAGGAGAGGGAGGAGACAGAGACGATGGAGAACCTGACTCGGCTG
CTCTTGGAGAACGTGCTCCCTGCACACGTGGCCCCCCAGTTCATTGGCCAGAACCGGCGC
AACGAGGATCTCTACCACCAGTCCTATGAATGCGTTTGTGTCCTCTTCGCCTCAGTCCCA
GACTTCAAGGAGTTCTACTCTGAATCCAACATCAATCATGAGGGCCTAGAGTGTCTGAGG
CTGCTCAATGAGATAATTGCTGATTTTGATGAGCTGCTCTCCAAGCCCAAGTTCAGTGGG
GTGGAGAAGATCAAGACCATCGGCAGCACCTACATGGCAGCCACAGGCTTAAATGCCACC
TCTGGACAGGATGCACAACAGGATGCTGAACGGAGCTGCAGCCACCTTGGCACTATGGTG
GAATTTGCCGTGGCCCTGGGGTCTAAGCTGGACGTCATCAACAAGCATTCATTCAACAAC
TTCCGCCTGCGAGTGGGGTTGAACCATGGACCCGTAGTAGCTGGAGTTATTGGGGCCCAG
AAGCCGCAATATGACATTTGGGGCAACACAGTGAACGTGGCCAGCCGCATGGAGAGTACA
GGAGTCCTTGGCAAAATCCAAGTGACTGAGGAGACAGCATGGGCCCTACAGTCCCTGGGC
TACACCTGCTACAGCCGGGGTGTCATCAAGGTGAAAGGCAAAGGGCAGCTCTGCACCTAC
TTCCTGAACACAGACTTGACACGAACTGGACCTCCTTCAGCTACCCTAGGCTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AF497516

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_7_Locus:
14q12

# Metabolic_Enzyme_7_SNPs:
rs3181252; rs3181385; rs882726; rs6573722; rs4981504; rs2332322; rs12436417; rs12891732; rs11626704; rs751877; rs17102928; rs17184682; rs3181254; rs11622527; rs1109152; rs3181257; rs12886362; rs17102976; rs10483285; rs1109153; rs17256902; rs17184689; rs4982897; rs2295303; rs12896809; rs3181256; rs1884366; rs4982896; rs11622863; rs2295302; rs12435732; rs11622406; rs12431793; rs3181255; rs3181382; rs17102926; rs3212260; rs2332323; rs3181384; rs3212257; rs3212259; rs1124644; rs3212256; rs3212258; rs35380285; rs3181386; rs3078135; rs34455539; rs12879950; rs2332321; rs10459527; rs4981505; rs12878316; rs2877642; rs8006514; rs2092866; rs10459528; rs726702; rs1950502; rs8003158; rs28769707; rs3841475; rs1007380; rs1007381; rs1046584; rs1046587; rs11844732; rs12436194; rs12588469; rs17103128; rs17256916; rs1950501; rs1950503; rs1950504; rs1950505; rs2180197; rs2224122; rs2295299; rs2295300; rs2295301; rs2516564; rs2748543; rs28379107; rs3181246; rs3181247; rs3181248; rs3181251; rs3181387; rs3181393; rs3212240; rs3212242; rs3212243; rs3212244; rs3212245; rs3212246; rs3212247; rs3212249; rs3212250; rs3212251; rs3212252; rs3212253; rs3212254; rs35322717; rs3742508; rs3742509; rs3742510; rs3742511; rs3759625; rs3759630; rs4981503; rs7153640; rs724165; rs8008406; rs8010276; rs8010550; rs8014599

# Metabolic_Enzyme_7_General_References:
12503609

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5903

# Metabolic_Enzyme_8_Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C

# Metabolic_Enzyme_8_Synonyms:
DPDE1; PDE21

# Metabolic_Enzyme_8_Gene_Name:
PDE4C

# Metabolic_Enzyme_8_Protein_Sequence:
>cAMPspecific 3',5'cyclic phosphodiesterase 4
CMENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRER
DLSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRES
FLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLG
AAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKR
ILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHS
ASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDL
LKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEIL
AALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQN
LSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQ
NLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVG
FIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFE
LTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT

# Metabolic_Enzyme_8_Number_of_Residues:
712

# Metabolic_Enzyme_8_Molecular_Weight:
79902

# Metabolic_Enzyme_8_Theoretical_pI:
4.84

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate

# Metabolic_Enzyme_8_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_8_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_8_GenBank_ID_Protein:
727223

# Metabolic_Enzyme_8_SwissProt_ID:
PDE4C_HUMAN (Q08493)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
PDE4C

# Metabolic_Enzyme_8_Geneatlas_id:
PDE4C

# Metabolic_Enzyme_8_hgnc_id:
HGNC:8782

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_8_Gene_Sequence:
>2139 bp
ATGGAGAACCTGGGGGTCGGCGAAGGGGCAGAGGCTTGCAGCAGGTTGAGTCGCTCTCGC
GGCCGCCACAGCATGACCAGAGCCCCGAAGCACCTGTGGCGGCAACCCCGGCGCCCCATC
CGCATCCAACAGCGCTTCTATTCGGATCCGGACAAGTCCGCGGGCTGCCGCGAGAGGGAC
CTGAGCCCGCGGCCGGAGCTCAGGAAGTCGCGGCTCTCCTGGCCCGTTTCCTCCTGCAGG
CGCTTTGACCTGGAAAATGGGCTCTCGTGTGGGAGGAGGGCCCTGGACCCTCAGTCCAGC
CCTGGCCTGGGCCGGATTATGCAGGCTCCAGTCCCGCACAGCCAGCGGCGCGAGTCCTTC
CTGTACCGCTCAGATAGCGACTATGAACTCTCGCCCAAGGCCATGTCTCGGAACTCCTCT
GTGGCCAGCGACCTACATGGAGAGGACATGATTGTGACGCCCTTTGCCCAGGTCCTGGCC
AGTCTGCGGACCGTTCGGAGCAACGTGGCGGCCCTTGCCCGCCAGCAATGCCTAGGAGCA
GCCAAGCAGGGACCCGTCGGAAACCCTTCATCCAGCAATCAGCTCCCTCCTGCAGAGGAC
ACGGGGCAGAAGCTGGCATTGGAGACGCTAGACGAGCTGGACTGGTGCCTGGATCAGTTG
GAGACGCTGCAGACCCGGCACTCGGTGGGGGAGATGGCCTCCAACAAGTTCAAGCGGATC
CTGAACCGGGAGTTGACCCACCTGTCCGAAACCAGCCGCTCCGGGAACCAGGTGTCCGAG
TACATCTCCCGGACCTTCCTGGACCAGCAGACCGAGGTGGAGCTGCCCAAGGTGACCGCT
GAGGAGGCCCCACAGCCCATGTCCCGGATCAGTGGCCTACATGGGCTCTGCCACAGTGCC
AGCCTCTCCTCAGCCACTGTCCCACGCTTTGGGGTCCAGACTGACCAGGAGGAGCAACTG
GCCAAGGAGCTAGAAGACACCAACAAGTGGGGACTTGATGTGTTCAAGGTGGCGGACGTA
AGTGGGAACCGGCCCCTCACAGCTATCATATTCAGCATTTTTCAGGAGCGGGACCTGCTG
AAGACATTCCAGATCCCAGCAGACACACTGGCCACCTACCTGCTGATGCTGGAGGGTCAC
TACCACGCCAATGTGGCCTACCACAACAGCCTACATGCCGCCGACGTGGCCCAGTCCACG
CATGTGCTGCTGGCTACGCCCGCCCTCGAGGCTGTGTTCACAGACTTGGAAATCCTGGCT
GCCCTCTTTGCAAGCGCCATCCACGACGTGGACCATCCTGGGGTCTCCAACCAGTTTCTG
ATTAACACCAACTCAGACGTGGCGCTTATGTACAACGACGCCTCGGTGCTGGAGAACCAT
CACCTGGCTGTGGGCTTCAAGCTGCTGCAGGCAGAGAACTGCGATATCTTCCAGAACCTC
AGCGCCAAGCAGCGACTGAGTCTGCGCAGGATGGTCATTGACATGGTGCTGGCCACAGAC
ATGTCCAAACACATGAACCTCCTGGCCGACCTCAAGACCATGGTGGAGACCAAGAAGGTG
ACAAGCCTCGGTGTCCTCCTCCTGGACAACTATTCCGACCGAATCCAGGTCTTGCAGAAC
CTGGTGCACTGTGCTGATCTGAGCAACCCCACCAAGCCGCTGCCCCTGTACCGCCAGTGG
ACGGACCGCATCATGGCCGAGTTCTTCCAGCAGGGAGACCGCGAGCGTGAGTCGGGCCTG
GACATCAGTCCCATGTGTGACAAGCATACGGCCTCAGTGGAGAAGTCCCAGGTGGGTTTC
ATTGACTACATTGCTCACCCACTGTGGGAGACTTGGGCTGACCTGGTCCACCCAGATGCA
CAGGACCTGCTGGACACGCTGGAGGACAATCGAGAGTGGTACCAGAGCAAGATCCCCCGA
AGTCCCTCAGACCTCACCAACCCCGAGCGGGACGGGCCTGACAGATTCCAGTTTGAACTG
ACTCTGGAGGAGGCAGAGGAAGAGGATGAGGAGGAAGAAGAGGAGGGGGAAGAGACAGCT
TTAGCCAAAGAGGCCTTGGAGTTGCCTGACACTGAACTCCTGTCCCCTGAAGCCGGCCCA
GACCCTGGGGACTTACCCCTCGACAACCAGAGGACTTAG

# Metabolic_Enzyme_8_GenBank_ID_Gene:
Z46632

# Metabolic_Enzyme_8_Chromosome_Location:
Not Available

# Metabolic_Enzyme_8_Locus:
Not Available

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
7843419; 10574328; 8413254

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5909

# Metabolic_Enzyme_9_Name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

# Metabolic_Enzyme_9_Synonyms:
GMP-PDE gamma

# Metabolic_Enzyme_9_Gene_Name:
PDE6G

# Metabolic_Enzyme_9_Protein_Sequence:
>Retinal rod rhodopsinsensitive cGMP 3',5'cyclic phosphodiesterase subunit gamma
MNLEPPKAEFRSATRVAGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGL
GTDITVICPWEAFNHLELHELAQYGII

# Metabolic_Enzyme_9_Number_of_Residues:
87

# Metabolic_Enzyme_9_Molecular_Weight:
9643

# Metabolic_Enzyme_9_Theoretical_pI:
10.16

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  cGMP-specific phosphodiesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones

# Metabolic_Enzyme_9_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_9_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF04868:PDE6_gamma

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_9_GenBank_ID_Protein:
189703

# Metabolic_Enzyme_9_SwissProt_ID:
CNRG_HUMAN (P18545)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
PDE6G

# Metabolic_Enzyme_9_Geneatlas_id:
PDE6G

# Metabolic_Enzyme_9_hgnc_id:
HGNC:8789

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_9_Gene_Sequence:
>264 bp
ATGAACCTGGAACCGCCCAAGGCTGAGTTCCGGTCAGCCACCAGGGTGGCCGGGGGACCT
GTCACCCCCAGGAAAGGGCCCCCTAAATTTAAGCAGCGACAGACCAGGCAGTTCAAGAGC
AAGCCCCCAAAGAAAGGCGTTCAAGGGTTTGGGGACGACATCCCTGGAATGGAAGGCCTG
GGAACAGACATCACAGTCATCTGCCCTTGGGAGGCCTTCAACCACCTGGAGCTGCACGAG
CTGGCCCAATATGGCATCATCTAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
M36476

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_9_Locus:
17q25

# Metabolic_Enzyme_9_SNPs:
rs3830068; rs1126818; rs8477; rs8908; rs3432; rs13372; rs11150803; rs7405790; rs7405798; rs7405870; rs1126835; rs12603868; rs7217415; rs7406825; rs11871837; rs7406828; rs8065526; rs11867395; rs12938981; rs11431043; rs7405799; rs34483867; rs35479959; rs36111499; rs7405655; rs12948839; rs3842709; rs12948797; rs35452055; rs12946993; rs12946445; rs2071451; rs34794441; rs35763415; rs11270790; rs8067026; rs7406904; rs34410653; rs8074225; rs35624022; rs7406891; rs12940128; rs12950388; rs11870066; rs8069538; rs8065141; rs11150804; rs11868728; rs34896443; rs35665020; rs35842897; rs6420484; rs6565616; rs6565617; rs7210026; rs7210043; rs7210193; rs7405629; rs7406678; rs7406705; rs7502320; rs7502869; rs9890264; rs9905410; rs9905639; rs9906358; rs9910935

# Metabolic_Enzyme_9_General_References:
2161380; 1965799; 8125719

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5979

# Metabolic_Enzyme_10_Name:
Adenylate cyclase type 6

# Metabolic_Enzyme_10_Synonyms:
Adenylate cyclase type VI; ATP pyrophosphate-lyase 6; Adenylyl cyclase 6; Ca(2+-inhibitable adenylyl cyclase

# Metabolic_Enzyme_10_Gene_Name:
ADCY6

# Metabolic_Enzyme_10_Protein_Sequence:
>Adenylate cyclase type 6
MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLT
PADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA
MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF
LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS
EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG
YQLECRGVVKVKGKGEMTTYFLNGGPSS

# Metabolic_Enzyme_10_Number_of_Residues:
1168

# Metabolic_Enzyme_10_Molecular_Weight:
130617

# Metabolic_Enzyme_10_Theoretical_pI:
8.27

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  cyclase activity
Function:  adenylate cyclase activity
Function:  catalytic activity
Function:  lyase activity
Function:  phosphorus-oxygen lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  cyclic nucleotide biosynthesis
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Metabolic_Enzyme_10_General_Function:
Signal transduction mechanisms 

# Metabolic_Enzyme_10_Specific_Function:
Membrane-bound, calcium-inhibitable adenylyl cyclase

# Metabolic_Enzyme_10_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_10_Reaction:
ATP = 3',5'-cyclic AMP + diphosphate

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF06327:DUF1053;
PF00211:Guanylate_cyc

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
152-168
181-197
214-230
239-255
259-275
289-305
674-691
702-718
743-759
820-836
839-855
897-913

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 4.6.1.1

# Metabolic_Enzyme_10_GenBank_ID_Protein:
9049783

# Metabolic_Enzyme_10_SwissProt_ID:
ADCY6_HUMAN (O43306)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
ADCY6

# Metabolic_Enzyme_10_Geneatlas_id:
ADCY6

# Metabolic_Enzyme_10_hgnc_id:
HGNC:237

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Membrane; multi-pass membrane protein

# Metabolic_Enzyme_10_Gene_Sequence:
>3507 bp
ATGTCATGGTTTAGTGGCCTCCTGGTCCCTAAAGTGGATGAACGGAAAACAGCCTGGGGC
GAACGCAATGGGCAGAAGCGTTCGCGGCGCCGTGGCACTCGGGCAGGTGGCTTCTGCACG
CCCCGCTATATGAGCTGCCTCCGGGATGCAGAGCCACCCAGCCCCACCCCTGCCGGCCCC
CCTCGGTGCCCCTGGCAGGATGACGCCTTCATCCGGAGGGGCGGCCCAGGCAAGGGCAAG
GAGCTGGGGCTGCGGGCAGTGGCCCTGGGCTTCGAGGATACCGAGGTGACAACGACAGCG
GGCGGGACGGCTGAGGTGGCGCCCGACGCGGTGCCCAGGAGTGGGCGATCCTGCTGGCGC
CGTCTGGTGCAGGTGTTCCAGTCGAAGCAGTTCCGTTCGGCCAAGCTGGAGCGCCTGTAC
CAGCGGTACTTCTTCCAGATGAACCAGAGCAGCCTGACGCTGCTGATGGCGGTGCTGGTG
CTGCTCACAGCGGTGCTGCTGGCTTTCCACGCCGCACCCGCCCGCCCTCAGCCTGCCTAT
GTGGCACTGTTGGCCTGTGCCGCCGCCCTGTTCGTGGGGCTCATGGTGGTGTGTAACCGG
CATAGCTTCCGCCAGGACTCCATGTGGGTGGTGAGCTACGTGGTGCTGGGCATCCTGGCG
GCAGTGCAGGTCGGGGGCGCTCTCGCAGCAGACCCGCGCAGCCCCTCTGCGGGCCTCTGG
TGCCCTGTGTTCTTTGTCTACATCGCCTACACGCTCCTCCCCATCCGCATGCGGGCTGCC
GTCCTCAGCGGCCTGGGCCTCTCCACCTTGCATTTGATCTTGGCCTGGCAACTTAACCGT
GGTGATGCCTTCCTCTGGAAGCAGCTCGGTGCCAATGTGCTGCTGTTCCTCTGCACCAAC
GTCATTGGCATCTGCACACACTATCCAGCAGAGGTGTCTCAGCGCCAGGCCTTTCAGGAG
ACCCGCGGTTACATCCAGGCCCGGCTCCACCTGCAGCATGAGAATCGGCAGCAGGAGCGG
CTGCTGCTGTCGGTATTGCCCCAGCACGTTGCCATGGAGATGAAAGAAGACATCAACACA
AAAAAAGAAGACATGATGTTCCACAAGATCTACATACAGAAGCATGACAATGTCAGCATC
CTGTTTGCAGACATTGAGGGCTTCACCAGCCTGGCATCCCAGTGCACTGCGCAGGAGCTG
GTCATGACCCTGAATGAGCTCTTTGCCCGGTTTGACAAGCTGGCTGCGGAGAATCACTGC
CTGAGGATCAAGATCTTGGGGGACTGTTACTACTGTGTGTCAGGGCTGCCGGAGGCCCGG
GCCGACCATGCCCACTGCTGTGTGGAGATGGGGGTAGACATGATTGAGGCCATCTCGCTG
GTACGTGAGGTGACAGGTGTGAATGTGAACATGCGCGTGGGCATCCACAGCGGGCGCGTG
CACTGCGGCGTCCTTGGCTTGCGGAAATGGCAGTTCGATGTGTGGTCCAATGATGTGACC
CTGGCCAACCACATGGAGGCAGGAGGCCGGGCTGGCCGCATCCACATCACTCGGGCAACA
CTGCAGTACCTGAACGGGGACTACGAGGTGGAGCCAGGCCGTGGTGGCGAGCGCAACGCG
TACCTCAAGGAGCAGCACATTGAGACTTTCCTCATCCTGGGCGCCAGCCAGAAACGGAAA
GAGGAGAAGGCCATGCTGGCCAAGCTGCAGCGGACTCGGGCCAACTCCATGGAAGGGCTG
ATGCCGCGCTGGGTTCCTGATCGTGCCTTCTCCCGGACCAAGGACTCCAAGGCCTTCCGC
CAGATGGGCATTGATGATTCCAGCAAAGACAACCGGGGCACCCAAGATGCCCTGAACCCT
GAGGATGAGGTGGATGAGTTCCTGAGCCGTGCCATCGATGCCCGCAGCATTGATCAGCTG
CGGAAGGACCATGTGCGCCGGTTTCTGCTCACCTTCCAGAGAGAGGATCTTGAGAAGAAG
TACTCCCGGAAGGTGGATCCCCGCTTCGGAGCCTACGTTGCCTGTGCCCTGTTGGTCTTC
TGCTTCATCTGCTTCATCCAGCTTCTCATCTTCCCACACTCCACCCTGATGCTTGGGATC
TATGCCAGCATCTTCCTGCTGCTGCTAATCACCGTGCTGATCTGTGCTGTGTACTCCTGT
GGTTCTCTGTTCCCTAAGGCCCTGCAACGTCTGTCCCGCAGCATTGTCCGCTCACGGGCA
CATAGCACCGCAGTTGGCATCTTTTCCGTCCTGCTTGTGTTTACTTCTGCCATTGCCAAC
ATGTTCACCTGTAACCACACCCCCATACGGAGCTGTGCAGCCCGGATGCTGAATTTAACA
CCTGCTGACATCACTGCCTGCCACCTGCAGCAGCTCAATTACTCTCTGGGCCTGGATGCT
CCCCTGTGTGAGGGCACCATGCCCACCTGCAGCTTTCCTGAGTACTTCATCGGGAACATG
CTGCTGAGTCTCTTGGCCAGCTCTGTCTTCCTGCACATCAGCAGCATCGGGAAGTTGGCC
ATGATCTTTGTCTTGGGGCTCATCTATTTGGTGCTGCTTCTGCTGGGTCCCCCAGCCACC
ATCTTTGACAACTATGACCTACTGCTTGGCGTCCATGGCTTGGCTTCTTCCAATGAGACC
TTTGATGGGCTGGACTGTCCAGCTGCAGGGAGGGTGGCCCTCAAATATATGACCCCTGTG
ATTCTGCTGGTGTTTGCGCTGGCGCTGTATCTGCATGCTCAGCAGGTGGAGTCGACTGCC
CGCCTAGACTTCCTCTGGAAACTACAGGCAACAGGGGAGAAGGAGGAGATGGAGGAGCTA
CAGGCATACAACCGGAGGCTGCTGCATAACATTCTGCCCAAGGACGTGGCGGCCCACTTC
CTGGCCCGGGAGCGCCGCAATGATGAACTCTACTATCAGTCGTGTGAGTGTGTGGCTGTT
ATGTTTGCCTCCATTGCCAACTTCTCTGAGTTCTATGTGGAGCTGGAGGCAAACAATGAG
GGTGTCGAGTGCCTGCGGCTGCTCAACGAGATCATCGCTGACTTTGATGAGATTATCAGC
GAGGAGCGGTTCCGGCAGCTGGAAAAGATCAAGACGATTGGTAGCACCTACATGGCTGCC
TCAGGGCTGAACGCCAGCACCTACGATCAGGTGGGCCGCTCCCACATCACTGCCCTGGCT
GACTACGCCATGCGGCTCATGGAGCAGATGAAGCACATCAATGAGCACTCCTTCAACAAT
TTCCAGATGAAGATTGGGCTGAACATGGGCCCAGTCGTGGCAGGTGTCATCGGGGCTCGG
AAGCCACAGTATGACATCTGGGGGAACACAGTGAATGTCTCTAGTCGTATGGACAGCACG
GGGGTCCCCGACCGAATCCAGGTGACCACGGACCTGTACCAGGTTCTAGCTGCCAAGGGC
TACCAGCTGGAGTGTCGAGGGGTGGTCAAGGTGAAGGGCAAGGGGGAGATGACCACCTAC
TTCCTCAATGGGGGCCCCAGCAGTTAA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
AF250226

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_10_Locus:
12q12-q13

# Metabolic_Enzyme_10_SNPs:
rs3730071; rs2453486; rs3730068; rs3730064; rs3730067; rs2446997; rs11168740; rs11168739; rs35801460; rs11168738; rs11168737; rs10875875; rs3730069; rs3730070; rs3729969; rs3729980; rs9804777; rs3730074; rs7300155; rs11168733; rs35468640; rs2291727; rs12306165; rs881738; rs10219743; rs11168734; rs10875874; rs3730072; rs3729972; rs3730065; rs11168732; rs11168742; rs2446998; rs34090269; rs3730307; rs3730308; rs35796720; rs7961282; rs3729973; rs12814893; rs34275095; rs34591537; rs1044574; rs35455549; rs11168736; rs2453487; rs7300621; rs34681523; rs7969346; rs3730066; rs17123331; rs34047364; rs12422232; rs11168731; rs10219585; rs3729970; rs36119408; rs34863395; rs35784184; rs12427399; rs11609140; rs35248828; rs7306801; rs35765758; rs12301271; rs28555113; rs34653184; rs11168743; rs10711161; rs11341881; rs35681944; rs10783284; rs11168728; rs11168745; rs2446990; rs4760645; rs7132180; rs7135449; rs7956275; rs7975385; rs9706255

# Metabolic_Enzyme_10_General_References:
10978539; 9455477; 12168954

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5906

# Metabolic_Enzyme_11_Name:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor

# Metabolic_Enzyme_11_Synonyms:
GMP-PDE beta

# Metabolic_Enzyme_11_Gene_Name:
PDE6B

# Metabolic_Enzyme_11_Protein_Sequence:
>Rod cGMPspecific 3',5'cyclic phosphodiesterase subunit beta precursor
MSLSEEQARSFLDQNPDFARQYFGKKLSPENVGRGCEDGCPPDCDSLRDLCQVEESTALL
ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE
DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI
MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL
WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY
SGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA
SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES
LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC
DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL
VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID
HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM
DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS
AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT
FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTEIC
NGGPAPKSSTCCIL

# Metabolic_Enzyme_11_Number_of_Residues:
854

# Metabolic_Enzyme_11_Molecular_Weight:
98408

# Metabolic_Enzyme_11_Theoretical_pI:
4.91

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Not Available

# Metabolic_Enzyme_11_Specific_Function:
This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme

# Metabolic_Enzyme_11_Pathway:
Not Available

# Metabolic_Enzyme_11_Reaction:
guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF01590:GAF;
PF00233:PDEase_I

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 3.1.4.35

# Metabolic_Enzyme_11_GenBank_ID_Protein:
252253

# Metabolic_Enzyme_11_SwissProt_ID:
PDE6B_HUMAN (P35913)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
PDE6B

# Metabolic_Enzyme_11_Geneatlas_id:
PDE6B

# Metabolic_Enzyme_11_hgnc_id:
HGNC:8786

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Membrane; lipid-anchor

# Metabolic_Enzyme_11_Gene_Sequence:
>2565 bp
ATGAGCCTCAGTGAGGAGCAGGCCCGGAGCTTTCTGGACCAGAACCCCGATTTTGCCCGC
CAGTACTTTGGGAAGAAACTGAGCCCTGAGAATGTTGGCCGCGGCTGCGAGGACGGGTGC
CCGCCGGACTGCGACAGCCTCCGGGACCTCTGCCAGGTGGAGGAGAGCACGGCGCTGCTG
GAGCTGGTGCAGGATATGCAGGAGAGCATCAACATGGAGCGCGTGGTCTTCAAGGTCCTG
CGGCGCCTCTGCACCCTCCTGCAGGCCGACCGCTGCAGCCTCTTCATGTACCGCCAGCGC
AACGGCGTGGCCGAGCTGGCCACCAGGCTTTTCAGCGTGCAGCCGGACAGCGTCCTGGAG
GACTGCCTGGTGCCCCCCGACTCCGAGATCGTCTTCCCACTGGACATCGGGGTCGTGGGC
CACGTGGCTCAGACCAAAAAGATGGTGAACGTCGAGGACGTGGCCGAGTGCCCTCACTTC
AGCTCATTTGCTGACGAGCTCACTGACTACAAGACAAAGAATATGCTGGCCACACCCATC
ATGAATGGCAAAGACGTCGTGGCGGTGATCATGGCAGTGAACAAGCTCAACGGCCCATTC
TTCACCAGCGAAGACGAAGATGTGTTCTTGAAGTACCTGAATTTTGCCACGTTGTACCTG
AAGATCTATCACCTGAGCTACCTCCACAACTGCGAGACGCGCCGCGGCCAGGTGCTGCTG
TGGTCGGCCAACAAGGTGTTTGAGGAGCTGACGGACATCGAGAGGCAGTTCCACAAGGCC
TTCTACACGGTGCGGGCCTACCTCAACTGCGAGCGGTACTCCGTGGGCCTCCTGGACATG
ACCAAGGAGAAGGAATTTTTTGACGTGTGGTCTGTGCTGATGGGAGAGTCCCAGCCGTAC
TCGGGCCCACGCACGCCTGATGGCCGGGAAATTGTCTTCTACAAAGTGATCGACTACATC
CTCCACGGCAAGGAGGAGATCAAGGTCATTCCCACACCCTCAGCCGATCACTGGGCCCTG
GCCAGCGGCCTTCCAAGCTACGTGGCAGAAAGCGGCTTTATTTGTAACATCATGAATGCT
TCCGCTGACGAAATGTTCAAATTTCAGGAAGGGGCCCTGGACGACTCCGGGTGGCTCATC
AAGAATGTGCTGTCCATGCCCATCGTCAACAAGAAGGAGGAGATTGTGGGAGTCGCCACA
TTTTACAACAGGAAAGACGGGAAGCCCTTTGACGAACAGGACGAGGTTCTCATGGAGTCC
CTGACACAGTTCCTGGGCTGGTCAGTGATGAACACCGACACCTACGACAAGATGAACAAG
CTGGAGAACCGCAAGGACATCGCACAGGACATGGTCCTTTACCACGTGAAGTGCGACAGG
GACGAGATCCAGCTCATCCTGCCAACCAGAGCGCGCCTGGGGAAGGAGCCTGCTGACTGC
GATGAGGACGAGCTGGGCGAAATCCTGAAGGAGGAGCTGCCAGGGCCCACCACATTTGAC
ATCTACGAATTCCACTTCTCTGACCTGGAGTGCACCGAACTGGACCTGGTCAAATGTGGC
ATCCAGATGTACTACGAGCTGGGCGTGGTCCGAAAGTTCCAGATCCCCCAGGAGGTCCTG
GTGCGGTTCCTGTTCTCCATCAGCAAAGGGTACCGGAGAATCACCTACCACAACTGGCGC
CACGGCTTCAACGTGGCCCAGACGATGTTCACGCTGCTCATGACCGGCAAACTGAAGAGC
TACTACACGGACCTGGAGGCCTTCGCCATGGTGACAGCCGGCCTGTGCCATGACATCGAC
CACCGCGGCACCAACAACCTGTACCAGATGAAGTCCCAGAACCCCTTGGCTAAGCTCCAC
GGCTCCTCGATTTTGGAGCGGCACCACCTGGAGTTTGGGAAGTTCCTGCTCTCGGAGGAG
ACCCTGAACATCTACCAGAACCTGAACCGGCGGCAGCACGAGCACGTGATCCACCTGATG
GACATCGCCATCATCGCCACGGACCTGGCCCTGTACTTCAAGAAGAGAGCGATGTTTCAG
AAGATCGTGGATGAGTCCAAGAACTACCAGGACAAGAAGAGCTGGGTGGAGTACCTGTCC
CTGGAGACGACCCGGAAGGAGATCGTCATGGCCATGATGATGACAGCCTGCGACCTGTCT
GCCATCACCAAGCCCTGGGAAGTCCAGAGCAAGGTCGCACTTCTCGTGGCTGCTGAGTTC
TGGGAGCAAGGTGACTTGGAAAGGACAGTCTTGGATCAGCAGCCCATTCCTATGATGGAC
CGGAACAAGGCGGCCGAGCTCCCCAAGCTGCAAGTGGGCTTCATCGACTTCGTGTGCACA
TTCGTGTACAAGGAGTTCTCTCGTTTCCACGAAGAGATCCTGCCCATGTTCGACCGACTG
CAGAACAATAGGAAAGAGTGGAAGGCGCTGGCTGATGAGTATGAGGCCAAAGTGAAGGCT
CTGGAGGAGAAGGAGGAGGAGGAGAGGGTGGCAGCCAAGAAAGTAGGCACAGAAATTTGC
AATGGCGGCCCAGCACCCAAGTCTTCAACCTGCTGTATCCTGTGA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
S41458

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_11_Locus:
4p16.3

# Metabolic_Enzyme_11_SNPs:
rs10029928; rs10007497; rs13101691; rs10030020; rs10023472; rs10029924; rs4075653; rs9994679; rs13133935; rs7438471; rs10031968; rs9997286; rs13116523; rs9998466; rs10033239; rs10017347; rs7669178; rs9999833; rs35925646; rs11734693; rs9991058; rs13127213; rs1135375; rs10031745; rs12501038; rs4426719; rs9995112; rs3895658; rs9996400; rs3888807; rs4690185; rs28568555; rs9992641; rs13139089; rs10027866; rs3891250; rs12331186; rs9998594; rs13117283; rs9998967; rs9996316; rs9998776; rs10027392; rs13107358; rs28414606; rs17849286; rs10902758; rs35792756; rs28510278; rs34380508; rs34749277; rs13106957; rs28675771; rs28710261; rs35513604; rs28862677; rs28538930; rs35535457; rs6858313; rs4292282; rs34281091; rs35498946; rs35714333; rs10010598; rs34698095; rs35621580; rs35691873; rs28711586; rs5021192; rs3934456; rs5855674; rs11945763; rs10050278; rs28588872; rs28569875; rs5021190; rs28583078; rs28483058; rs3929990; rs9985747; rs35214302; rs35436502; rs28438722; rs34845372; rs34165278; rs28573204; rs28459140; rs10028526; rs34477049; rs28600205; rs34953355; rs10018607; rs34587890; rs10014936; rs34149873; rs13133489; rs28520978; rs3929992; rs10028537; rs34992186; rs4690283; rs5021193; rs4505760; rs35207129; rs36117387; rs34568772; rs10027549; rs34524643; rs13143262; rs28374488; rs35935310; rs3929994; rs13143260; rs13103955; rs28476575; rs36060793; rs10024023; rs34096984; rs28742899; rs3934458; rs28754797; rs4690184; rs13143415; rs28502612; rs34328631; rs13140649; rs35564967; rs35134635; rs34549884; rs34177362; rs13119631; rs35732782; rs10011154; rs28615478; rs34101587; rs28438498; rs34391278; rs28478159; rs10001451; rs3934457; rs28469188; rs35448666; rs13114329; rs28380593; rs11932953; rs4690287; rs34415705; rs3934459; rs9990446; rs28742266; rs28399001; rs28485445; rs4549330; rs35694609; rs28407346; rs10017435; rs28818828; rs10023609; rs35649145; rs34902595; rs5021189; rs34612826; rs34585712; rs28605120; rs5021195; rs3864131; rs28706206; rs35669257; rs3864130; rs35400657; rs28514424; rs13114327; rs3929991; rs34363025; rs28413992; rs35584659; rs34366493; rs34907702; rs10002807; rs7436737; rs35137658; rs35978649; rs34721231; rs36093261; rs34421911; rs13109818; rs35972513; rs28483373; rs28630797; rs33997822; rs13104193; rs3929993; rs34756574; rs35958508; rs34358706; rs35847945; rs35894204; rs28687729; rs10035021; rs28436699; rs5021194; rs13119162; rs35853545; rs5021191; rs34801629; rs35556851; rs28586910; rs28504161; rs13140494; rs28488910; rs10007206; rs35869797; rs34290798; rs7699579; rs4446259; rs13115440; rs28477853; rs28535694; rs5021196; rs34094325; rs28665728; rs35199616; rs9998968; rs13107385; rs13128568; rs13147797; rs13128747; rs13104878; rs13145071; rs1802515; rs28525003; rs34268219; rs34307246; rs35091443; rs4463020; rs4690183; rs7665160

# Metabolic_Enzyme_11_General_References:
8394243; 1338685; 1322354; 1720239; 8768262; 8394174; 8075643; 7951329; 8595886; 8698075; 8557257; 8956055; 9543643

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5980

# Metabolic_Enzyme_12_Name:
Adenylate cyclase type 5

# Metabolic_Enzyme_12_Synonyms:
Adenylate cyclase type V; ATP pyrophosphate-lyase 5; Adenylyl cyclase 5

# Metabolic_Enzyme_12_Gene_Name:
ADCY5

# Metabolic_Enzyme_12_Protein_Sequence:
>Adenylate cyclase type 5
MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGA
VTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRR
GAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEG
GEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQS
SLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGL
ACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSAL
HLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLH
SQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTS
LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM
GMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK
AGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMN
RQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFL
GRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQI
TIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVF
TITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSP
WPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADL
LVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKL
QATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANF
SEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTY
DKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWG
NTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPL
S

# Metabolic_Enzyme_12_Number_of_Residues:
1261

# Metabolic_Enzyme_12_Molecular_Weight:
138909

# Metabolic_Enzyme_12_Theoretical_pI:
7.25

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  cyclase activity
Function:  adenylate cyclase activity
Function:  catalytic activity
Function:  lyase activity
Function:  phosphorus-oxygen lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  cyclic nucleotide biosynthesis
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Metabolic_Enzyme_12_General_Function:
Signal transduction mechanisms 

# Metabolic_Enzyme_12_Specific_Function:
This is a membrane-bound, calcium-inhibitable adenylyl cyclase

# Metabolic_Enzyme_12_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_12_Reaction:
ATP = 3',5'-cyclic AMP + diphosphate

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF06327:DUF1053;
PF00211:Guanylate_cyc

# Metabolic_Enzyme_12_Signals:
None

# Metabolic_Enzyme_12_Transmembrane_Regions:
196-216
242-262
268-288
299-319
325-345
349-369
374-394
770-790
792-812
836-856
910-930
935-955
984-1004

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 4.6.1.1

# Metabolic_Enzyme_12_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_12_SwissProt_ID:
ADCY5_HUMAN (O95622)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
ADCY5

# Metabolic_Enzyme_12_Geneatlas_id:
ADCY5

# Metabolic_Enzyme_12_hgnc_id:
HGNC:236

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Membrane; multi-pass membrane protein

# Metabolic_Enzyme_12_Gene_Sequence:
Not Available

# Metabolic_Enzyme_12_GenBank_ID_Gene:
AC025571

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_12_Locus:
3q13.2-q21

# Metabolic_Enzyme_12_SNPs:
rs1456116; rs1000368; rs2877709; rs6784288; rs2009176; rs6807089; rs4677886; rs4234212; rs12487712; rs4678022; rs9856983; rs4630884; rs4073374; rs6795648; rs6764842; rs1018060; rs7641344; rs6797908; rs4678015; rs9840967; rs12636451; rs4678002; rs6774571; rs4677887; rs6777397; rs9844212; rs4678004; rs9822061; rs4677884; rs6806851; rs4678008; rs6783913; rs7636160; rs3935400; rs4474982; rs7614840; rs4678001; rs4678009; rs3934729; rs12631135; rs4467388; rs4596093; rs4450740; rs12631960; rs9289221; rs9879000; rs903574; rs6790286; rs7616545; rs4678005; rs4621278; rs9881951; rs7650902; rs9819254; rs12486065; rs931574; rs9841477; rs6766089; rs6438788; rs17361324; rs9289218; rs4677888; rs4678014; rs6778215; rs9857526; rs9289220; rs9847700; rs6799662; rs6801735; rs11923649; rs11923120; rs1018061; rs9865576; rs6790410; rs6438793; rs4678010; rs2332509; rs12633873; rs9861425; rs9881942; rs924018; rs9870651; rs6798189; rs10934647; rs9839740; rs2062432; rs7612096; rs11708067; rs2124499; rs6789820; rs11711950; rs903572; rs6438787; rs12633849; rs2055168; rs17360897; rs11717195; rs6790681; rs4678025; rs6770454; rs6781704; rs4678018; rs11927367; rs3845913; rs3935566; rs10049128; rs11715633; rs4678023; rs4677889; rs9826728; rs12634663; rs6794936; rs12631101; rs10451896; rs9829332; rs9861812; rs9883204; rs6770805; rs6800468; rs9856662; rs11711009; rs17295401; rs6762009; rs2877716; rs9839081; rs4482616; rs931575; rs9850375; rs4678021; rs4678017; rs9857544; rs6803327; rs4678003; rs903571; rs12631979; rs17295246; rs10934643; rs9862885; rs1378803; rs2124500; rs726835; rs6771801; rs6438790; rs6801416; rs1378805; rs7613951; rs9817715; rs9683290; rs4678024; rs16834219; rs6771700; rs4677881; rs1552352; rs4072922; rs10048968; rs16834258; rs6794202; rs9875087; rs4327330; rs10934646; rs9858150; rs9841543; rs7429365; rs1563425; rs6803102; rs4093840; rs9289222; rs9862767; rs2055169; rs11705759; rs12493479; rs4677882; rs12638918; rs7653529; rs16834218; rs13096385; rs6790843; rs6790540; rs1552353; rs6801826; rs10934645; rs4678016; rs4678007; rs6806529; rs9824181; rs7614016; rs6804055; rs9844840; rs9855635; rs9631459; rs13058985; rs10048957; rs4234214; rs9856467; rs9872683; rs11712805; rs4467387; rs2332540; rs1350151; rs17295582; rs13082514; rs4470442; rs4528887; rs9849919; rs9289219; rs2332510; rs9872572; rs1018059; rs4678020; rs1869860; rs903575; rs9875803; rs4072921; rs11714441; rs6794803; rs12637493; rs4677880; rs9851257; rs4383453; rs17295346; rs6793532; rs2055167; rs12496583; rs4328752; rs6806929; rs924017; rs6797915; rs9857714; rs11720108; rs11918432; rs11708903; rs9809236; rs12629585; rs6794886; rs6438792; rs9840752; rs7635110; rs34970607; rs9790301; rs9855969; rs7644737; rs6784930; rs13317079; rs9820928; rs9814496; rs9823553; rs11382207; rs35084402; rs11447355; rs35856404; rs13082029; rs34495292; rs35236560; rs9861119; rs10663031; rs34044696; rs13097534; rs9844230; rs35652838; rs13099469; rs6767514; rs9878646; rs11369461; rs34254316; rs11707746; rs35538838; rs6782131; rs34933523; rs12632353; rs35716967; rs34002432; rs34279288; rs11929679; rs34674742; rs10663844; rs9842504; rs35866067; rs1874310; rs34199986; rs35300881; rs6807239; rs7613109; rs1147742; rs28654158; rs4322948; rs34128140; rs5852331; rs10640874; rs34440281; rs34899301; rs6800813; rs34640453; rs34411635; rs35625292; rs931577; rs9817887; rs11428784; rs4678006; rs35626615; rs6764737; rs4437082; rs34128970; rs36088664; rs13327692; rs2055166; rs9868104; rs33929559; rs36118634; rs34613177; rs6799356; rs5852335; rs35662855; rs7615188; rs13081065; rs34579092; rs11924387; rs34756449; rs9854862; rs9631457; rs11712575; rs6148049; rs11425939; rs1814046; rs34160272; rs35864750; rs1456115; rs962534; rs11919374; rs34292178; rs13067899; rs41435846; rs3935734; rs10576520; rs34188304; rs13082039; rs9839264; rs10669335; rs11719201; rs35353708; rs10574810; rs34838297; rs10600840; rs9877581; rs34851367; rs5852334; rs35396016; rs11427256; rs9874390; rs764032; rs11317143; rs34170552; rs1872560; rs34855792; rs10709804; rs35432842; rs34060023; rs4234213; rs2171144; rs5852336; rs35673177; rs9844550; rs1968891; rs11382208; rs34008208; rs936845; rs34452014; rs11302598; rs13078718; rs35747919; rs9879597; rs13318890; rs35841686; rs11709065; rs10703519; rs9842029; rs28627009; rs35577835; rs10551109; rs11371880; rs35301865; rs9869970; rs28666839; rs35128014; rs5852330; rs13079140; rs5852337; rs35601238; rs3083332; rs34642857; rs34986941; rs7638579; rs34760561; rs9857506; rs9820168; rs35100974; rs11276119; rs34259505; rs10605876; rs10574811; rs6787408; rs10702584; rs35942678; rs35913161; rs35237562; rs35391409; rs1456117; rs35606005; rs35069338; rs6808619; rs2168433; rs10934644; rs28532846; rs9866917; rs11456981; rs5852333; rs9841404; rs4626035; rs12330631; rs34485840; rs9834282; rs11371694; rs9818519; rs931576; rs35534865; rs11706781; rs35888908; rs35511027; rs35628726; rs7429097; rs35543900; rs13074563; rs11307047; rs10704227; rs11393711; rs10612873; rs4677883; rs4375989; rs34114548; rs34315963; rs11280339; rs9815903; rs7633101; rs4473508; rs9865168; rs34293910; rs5852338; rs34520988; rs9882930; rs730521; rs3935735; rs28463650; rs6803960; rs7644532; rs6802207; rs10655771; rs34751648; rs28460207; rs6767844; rs9653920; rs35727728; rs35030930; rs35895488; rs35578459; rs9858997; rs35240092; rs10642355; rs35735057; rs9861647; rs35633798; rs34279262; rs13097463; rs35809254; rs35931380; rs1947509; rs36083285; rs4677885; rs13076594; rs9827483; rs11720702; rs9882534; rs6438789; rs6803100; rs10620836; rs35391513; rs34995665; rs34757995; rs34121007; rs11709978; rs11919083; rs1869861; rs10522987; rs35377407; rs34619521; rs35392858; rs35519015; rs35936901; rs11705774; rs11430377; rs10662985; rs9821530; rs6794611; rs13062818; rs7650886; rs28566141; rs28473505; rs28371826; rs11709983; rs7632879; rs11438345; rs11283039; rs1254642; rs34374347; rs34371859; rs6808040; rs35750360; rs2168434; rs13082030; rs35488886; rs11293802; rs35182468; rs10620477; rs2332541; rs9631460; rs9653919; rs35171060; rs34573753; rs11286842; rs28452594; rs11347100; rs11286843; rs33975833; rs35596775; rs11717793; rs4678019; rs34039268; rs33977316; rs5852332; rs11915884; rs9814758; rs9653895; rs10666762; rs9631458; rs9858285; rs4499546; rs11425663; rs34060574; rs11709386; rs11709903; rs13074111; rs4077111; rs4077386; rs4574219; rs4677999; rs4678028; rs4678030; rs6769660; rs6770459; rs6785344; rs6795343; rs6809407; rs7433523; rs7611988; rs7621302; rs7643648; rs9858598; rs9863932; rs9870120

# Metabolic_Enzyme_12_General_References:
12503609; 10481931

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5981

# Metabolic_Enzyme_13_Name:
Adenylate cyclase type 8

# Metabolic_Enzyme_13_Synonyms:
Adenylate cyclase type VIII; ATP pyrophosphate-lyase 8; Adenylyl cyclase 8; Ca(2+/calmodulin- activated adenylyl cyclase

# Metabolic_Enzyme_13_Gene_Name:
ADCY8

# Metabolic_Enzyme_13_Protein_Sequence:
>Adenylate cyclase type 8
MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGS
GSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASG
SGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRK
SEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHT
YLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTS
LLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEAR
LRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADV
KGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAH
CCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKL
ESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPED
IVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHV
QSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAF
IVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINE
TYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTG
VLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEV
SLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVA
RHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDE
LLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKH
SFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLIL
KDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLV
QSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP

# Metabolic_Enzyme_13_Number_of_Residues:
1251

# Metabolic_Enzyme_13_Molecular_Weight:
140124

# Metabolic_Enzyme_13_Theoretical_pI:
6.99

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  cyclase activity
Function:  adenylate cyclase activity
Function:  catalytic activity
Function:  lyase activity
Function:  phosphorus-oxygen lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  cyclic nucleotide biosynthesis
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Metabolic_Enzyme_13_General_Function:
Signal transduction mechanisms 

# Metabolic_Enzyme_13_Specific_Function:
This is a membrane-bound, calcium-inhibitable adenylyl cyclase. May be involved in learning, in memory and in drug dependence

# Metabolic_Enzyme_13_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_13_Reaction:
ATP = 3',5'-cyclic AMP + diphosphate

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF06327:DUF1053;
PF00211:Guanylate_cyc

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
183-203
212-232
247-267
274-294
296-316
321-341
716-736
738-758
787-807
831-851
861-881
894-914

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 4.6.1.1

# Metabolic_Enzyme_13_GenBank_ID_Protein:
516263

# Metabolic_Enzyme_13_SwissProt_ID:
ADCY8_HUMAN (P40145)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
ADCY8

# Metabolic_Enzyme_13_Geneatlas_id:
ADCY8

# Metabolic_Enzyme_13_hgnc_id:
HGNC:239

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Membrane; multi-pass membrane protein

# Metabolic_Enzyme_13_Gene_Sequence:
>3756 bp
ATGGAGCTCTCCGATGTGCGCTGCCTTACAGGCAGCGAGGAACTCTACACCATCCACCCG
ACGCCCCCGGCCGGCGACGGCAGGAGCGCCTCCCGGCCGCAGCGGCTGCTGTGGCAGACG
GCGGTGCGACACATCACGGAGCAGCGCTTCATTCACGGGCACCGGGGAGGCAGCGGCAGC
GGGAGTGGAGGCTCGGGCAAAGCCTCGGACCCTGCGGGCGGCGGCCCCAACCACCACGCG
CCGCAGCTGTCAGGCGACTCGGCGCTGCCCCTCTACTCGCTGGGCCCGGGAGAGCGAGCG
CACAGCACCTGCGGCACCAAAGTCTTCCCGGAACGCAGCGGGAGCGGCAGTGCCAGCGGC
AGCGGAGGCGGGGGCGACCTGGGCTTCCTGCACCTTGACTGTGCCCCTAGCAACTCGGAT
TTCTTTCTTAATGGGGGCTATAGCTACCGAGGGGTCATTTTCCCCACCCTGCGCAACTCC
TTCAAATCTCGGGATTTGGAACGCCTCTACCAGCGCTATTTCTTGGGCCAAAGGCGCAAA
TCGGAAGTGGTGATGAACGTGCTGGACGTGCTGACCAAACTCACTCTCTTGGTCCTACAC
TTGAGCCTGGCCTCGGCCCCCATGGACCCGCTCAAGGGCATCCTGCTGGGCTTCTTCACC
GGCATTGAGGTAGTGATCTGCGCCCTGGTGGTGGTCAGGAAGGACACCACCTCCCACACG
TACCTGCAGTACAGCGGCGTGGTCACCTGGGTGGCCATGACCACCCAGATCCTGGCAGCA
GGCCTCGGCTACGGGCTCCTGGGCGACGGCATAGGCTACGTGCTCTTCACGCTCTTCGCC
ACCTACAGTATGCTGCCGCTGCCGCTCACCTGGGCCATCCTGGCCGGCCTGGGCACCTCG
CTGCTGCAGGTCATCCTCCAAGTGGTCATACCCCGGCTGGCGGTCATTTCCATCAACCAG
GTTGTGGCCCAGGCAGTGCTATTCATGTGTATGAACACAGCTGGAATCTTCATCAGTTAC
CTGTCAGACCGGGCCCAGCGCCAAGCTTTCCTGGAGACTCGGAGGTGTGTGGAGGCCAGG
CTGCGCCTGGAGACAGAGAACCAAAGACAGGAGCGGCTCGTGCTTTCTGTGCTCCCCCGG
TTTGTTGTCCTGGAAATGATCAACGACATGACCAATGTGGAAGATGAGCACCTGCAGCAC
CAGTTCCATCGGATCTACATCCATCGCTATGAGAACGTCAGTATTCTTTTTGCAGATGTT
AAAGGATTTACCAACCTCTCCACGACCTTGTCTGCTCAGGAGCTGGTCAGGATGCTCAAC
GAGCTCTTTGCCAGATTTGATCGACTGGCCCATGAGCATCACTGCCTTCGTATTAAAATC
CTGGGGGACTGCTACTACTGCGTGTCTGGACTTCCTGAGCCCCGCCAGGACCATGCCCAC
TGCTGTGTTGAAATGGGTCTCAGCATGATCAAAACCATCAGGTATGTGCGGTCAAGGACA
AAACACGATGTTGACATGAGGATTGGAATCCACTCCGGCTCGGTGCTGTGCGGTGTTTTG
GGACTACGGAAGTGGCAGTTTGATGTCTGGTCTTGGGATGTGGATATTGCAAACAAACTC
GAATCTGGAGGAATCCCCGGGAGGATTCACATTTCCAAAGCCACGCTGGACTGTCTCAAC
GGTGACTATAACGTGGAAGAGGGCCATGGTAAAGAGAGGAATGAATTCCTGAGGAAGCAT
AATATCGAAACTTACTTAATTAAGCAGCCTGAGGACAGTCTGCTGTCCTTGCCTGAAGAT
ATCGTCAAGGAGTCAGTGAGCTCCTCAGACCGGAGAAACAGTGGGGCCACATTCACTGAA
GGATCCTGGAGCCCTGAACTGCCCTTTGATAATATCGTGGGGAAACAGAATACTCTGGCT
GCCCTAACAAGAAATTCAATAAATCTGCTTCCAAACCATCTTGCACAAGCTTTGCATGTC
CAGTCTGGGCCTGAGGAAATTAACAAGAGAATAGAACATACCATCGACTTGCGGAGTGGC
GATAAATTGAGAAGAGAGCATATCAAGCCATTCTCACTGATGTTTAAAGACTCCAGCCTG
GAGCACAAGTATTCTCAAATGAGGGATGAAGTGTTCAAGTCAAACTTGGTCTGTGCATTT
ATCGTTCTTCTATTTATCACGGCAATACAAAGTTTGCTTCCTTCTTCAAGAGTGATGCCA
ATGACCATCCAGTTCTCCATTCTGATTATGCTGCACTCGGCTCTGGTCCTCATCACCACA
GCAGAGGATTATAAATGTTTGCCCCTCATCCTCCGGAAAACTTGCTGTTGGATTAATGAG
ACCTATTTGGCCCGGAACGTCATCATCTTTGCATCCATTTTGATTAATTTCCTGGGTGCC
ATCTTAAATATCCTGTGGTGTGATTTTGACAAGTCGATACCCTTGAAGAACCTGACTTTC
AATTCCTCAGCTGTGTTTACAGATATCTGCTCCTACCCAGAGTACTTTGTCTTCACGGGG
GTGTTGGCCATGGTGACCTGTGCAGTTTTCCTCCGGCTGAACTCCGTCCTGAAGCTGGCA
GTGCTGCTGATCATGATTGCCATCTATGCCCTGCTCACTGAGACCGTCTACGCAGGCCTC
TTTCTGCGTTATGACAACCTCAACCACAGTGGAGAAGATTTCCTGGGGACCAAGGAGGTA
TCACTGCTACTGATGGCCATGTTCCTCCTGGCTGTGTTCTACCATGGACAGCAGCTGGAG
TACACAGCCCGCCTGGACTTCCTTTGGCGAGTACAGGCCAAAGAGGAGATCAATGAGATG
AAGGAGCTGAGGGAACACAATGAGAACATGCTCCGGAATATCTTACCCAGCCATGTGGCC
CGCCATTTCCTAGAGAAGGACCGAGACAATGAGGAGCTGTATTCTCAATCCTATGATGCT
GTTGGGGTGATGTTTGCCTCCATCCCAGGATTTGCGGACTTTTACTCTCAGACTGAAATG
AATAACCAGGGAGTGGAATGCCTGCGCTTGCTCAATGAGATCATTGCTGACTTCGATGAG
TTGCTTGGTGAAGACCGATTTCAAGACATTGAAAAGATTAAGACCATTGGCAGCACCTAC
ATGGCCGTGTCAGGCCTGTCACCTGAAAAACAGCAATGTGAAGACAAGTGGGGACATTTG
TGTGCTCTGGCTGACTTCTCACTCGCCCTGACAGAAAGCATACAGGAGATCAACAAGCAT
TCATTCAACAATTTTGAACTCCGGATTGGCATCAGCCACGGCTCAGTGGTAGCTGGCGTT
ATCGGCGCTAAGAAACCACAGTATGACATTTGGGGCAAAACTGTGAACCTGGCAAGCCGA
ATGGACAGCACGGGGGTTAGTGGCCGGATCCAAGTCCCAGAGGAGACCTATCTCATCCTG
AAGGACCAGGGCTTTGCCTTTGATTACCGAGGGGAGATCTATGTGAAGGGTATCAGTGAA
CAGGAAGGAAAAATCAAAACGTACTTTCTTCTGGGAAGAGTCCAACCCAACCCATTCATC
TTGCCCCCAAGAAGACTGCCTGGGCAGTACTCCCTGGCCGCGGTTGTCCTGGGACTTGTC
CAGTCCCTCAATAGGCAAAGGCAGAAGCAGCTACTCAATGAGAACAACAACACAGGAATC
ATCAAGGGTCATTACAACCGGCGGACTTTGTTGTCACCCAGCGGCACAGAGCCTGGAGCC
CAGGCTGAAGGCACCGACAAATCTGATTTGCCATAA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
Z35309

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_13_Locus:
8q24

# Metabolic_Enzyme_13_SNPs:
rs2228949; rs12547243; rs13278912; rs12545028; rs913818; rs3829210; rs867964; rs185510; rs430659; rs263252; rs873666; rs2060473; rs1411185; rs2664380; rs398267; rs959204; rs1435447; rs263241; rs263234; rs1836630; rs1329798; rs263256; rs263240; rs2917050; rs1888082; rs913819; rs1329803; rs166405; rs263232; rs263264; rs263274; rs263250; rs1435451; rs884102; rs2917048; rs263230; rs1411179; rs2164304; rs1411184; rs1157822; rs263248; rs1411186; rs365538; rs2917049; rs263269; rs2376823; rs1411180; rs1411187; rs2917065; rs2917051; rs1329804; rs10098645; rs12549193; rs263238; rs7828958; rs7012698; rs10097729; rs183801; rs6470869; rs1023096; rs4736688; rs6470861; rs4392877; rs6980820; rs4736707; rs6996688; rs4736727; rs873667; rs6997439; rs6998224; rs965815; rs10956569; rs263271; rs2196315; rs6470867; rs3923135; rs6993226; rs12674631; rs6470866; rs1396980; rs12682035; rs6470877; rs11783792; rs7831098; rs7832185; rs7830999; rs4736463; rs12540966; rs4736722; rs7010900; rs4736725; rs6986535; rs11777920; rs10108431; rs263261; rs7815277; rs6470874; rs6992043; rs10098660; rs6470859; rs6997190; rs7813291; rs7812946; rs7460412; rs263263; rs1411181; rs12545999; rs1329805; rs7016933; rs6997554; rs4736726; rs7461848; rs10108440; rs7838870; rs6470860; rs6980986; rs2917053; rs965814; rs6470878; rs2954690; rs7837610; rs10104127; rs7842798; rs6415523; rs7460024; rs1435446; rs10956551; rs10956568; rs6470864; rs2259296; rs932904; rs7461282; rs12546136; rs6470868; rs1023095; rs6470875; rs11991124; rs10103045; rs4130329; rs10956553; rs10090355; rs12680529; rs7014446; rs6470881; rs7465065; rs4736723; rs1509843; rs12549142; rs11995961; rs7461026; rs11776563; rs263253; rs190527; rs7459733; rs1369451; rs4128982; rs7459573; rs3793387; rs7460331; rs7843541; rs2860416; rs12680568; rs3793393; rs3914070; rs263249; rs6470873; rs1030787; rs1588369; rs4736730; rs7013860; rs7015079; rs263260; rs1509860; rs4474042; rs7461303; rs11989940; rs263255; rs7820412; rs6997744; rs6986870; rs10956570; rs7461448; rs12549392; rs2917052; rs12542315; rs7014917; rs13340584; rs1411177; rs166403; rs10106854; rs6991107; rs4341178; rs885381; rs7009351; rs7464362; rs6470863; rs4339660; rs412723; rs263262; rs2889477; rs10505566; rs17226545; rs7459542; rs12678910; rs16904392; rs11781742; rs6993838; rs1411183; rs10098452; rs1411182; rs12548835; rs263266; rs12678961; rs11776474; rs174493; rs12548296; rs7840509; rs13258076; rs976267; rs7829177; rs7015909; rs263231; rs2917054; rs7845934; rs6470865; rs10109100; rs4130328; rs12678691; rs6470872; rs448852; rs12156272; rs7846645; rs11995439; rs263236; rs6470883; rs724365; rs7001427; rs4736733; rs11989229; rs2210061; rs6415520; rs11776501; rs6986731; rs7813636; rs10956561; rs16904357; rs1560985; rs6470876; rs7009501; rs6987081; rs11774222; rs11992291; rs187815; rs16904374; rs397297; rs6992750; rs11786442; rs191736; rs11774077; rs12676386; rs7011132; rs6995900; rs17327900; rs17326441; rs6470870; rs7820461; rs13261265; rs11988309; rs10956567; rs1411178; rs70994; rs11784371; rs11779492; rs12545796; rs7843127; rs3829032; rs10108845; rs12679904; rs11779286; rs1831321; rs10956552; rs11781997; rs2304396; rs13278937; rs2217826; rs4736731; rs7011483; rs10755934; rs263237; rs3750889; rs11777206; rs12678403; rs12543858; rs11780690; rs928136; rs4376482; rs16904358; rs7840086; rs11786761; rs7001417; rs12544368; rs166402; rs1369450; rs885380; rs9297815; rs4736729; rs6415525; rs17324385; rs12545113; rs11990501; rs7463591; rs11779887; rs7824021; rs263242; rs4129258; rs12674666; rs1556163; rs11777051; rs1360208; rs1435449; rs7841164; rs11775091; rs6984014; rs744901; rs2954692; rs16904360; rs11998329; rs1590868; rs11777665; rs3793389; rs6980959; rs11775729; rs17248206; rs3793391; rs1509857; rs12540962; rs7460718; rs10956563; rs6470871; rs11776645; rs12550576; rs7463800; rs12546275; rs12375420; rs10090592; rs377711; rs724366; rs1605902; rs6986777; rs4389913; rs4736717; rs6993816; rs17327852; rs7825294; rs6470862; rs16904391; rs976266; rs263258; rs4736706; rs2917055; rs16904384; rs7465434; rs1590869; rs11987135; rs7824237; rs16904375; rs17226587; rs6987663; rs4736464; rs1543020; rs3914071; rs10090658; rs12550604; rs2164306; rs6997062; rs10505567; rs4389912; rs402620; rs5026644; rs6470884; rs384271; rs263254; rs3923136; rs263267; rs6415528; rs4736732; rs1509859; rs11776982; rs963215; rs263268; rs7461923; rs1028945; rs12675820; rs928138; rs7461315; rs10090411; rs10093375; rs7461547; rs12543363; rs7812586; rs11997802; rs4736728; rs2954691; rs12546036; rs10505565; rs10956564; rs4736462; rs10956566; rs263235; rs6987249; rs11776881; rs11774179; rs12547454; rs6986982; rs10103606; rs7009575; rs11995918; rs263272; rs166404; rs1831322; rs13276752; rs6991158; rs12680002; rs11777032; rs16904393; rs12155837; rs9649965; rs7821012; rs16904362; rs6470879; rs7835943; rs7001517; rs7465008; rs928137; rs11987978; rs976268; rs6415524; rs12680511; rs263233; rs1605901; rs9297816; rs6988204; rs263257; rs1509850; rs7007726; rs7824494; rs16904367; rs11781963; rs7000131; rs13274422; rs6987807; rs6983987; rs16904379; rs13248582; rs263259; rs190526; rs11784183; rs2572868; rs1119768; rs17225958; rs9942760; rs7460375; rs7001029; rs7459621; rs10956562; rs16904355; rs7832434; rs11986118; rs16904361; rs7839682; rs409934; rs9720531; rs4736735; rs6998875; rs3923137; rs7813405; rs16904399; rs9721185; rs12334868; rs192344; rs11785149; rs11993202; rs1509851; rs7462372; rs964560; rs11784418; rs16904363; rs7014133; rs13260940; rs7826893; rs12681775; rs11781295; rs7465009; rs10109398; rs6651256; rs11776361; rs7815264; rs3793392; rs10089947; rs6470882; rs2014815; rs9942751; rs16904387; rs10087086; rs12335232; rs11775974; rs17248988; rs16904397; rs7824132; rs263273; rs2664388; rs884423; rs2308221; rs10090182; rs16904376; rs7461461; rs7000804; rs7837721; rs190525; rs6982929; rs4504612; rs11782471; rs10956565; rs3849807; rs11780463; rs16904380; rs7813114; rs4736461; rs7009300; rs10103256; rs17226139; rs4736734; rs13268234; rs12543125; rs17227830; rs7841097; rs4388440; rs7815151; rs6988340; rs263239; rs16904371; rs6415522; rs9918819; rs7006754; rs4477040; rs7007107; rs7004104; rs1509858; rs7819655; rs10113163; rs16904364; rs6984097; rs4736724; rs10089835; rs10091502; rs1897982; rs7818971; rs12155944; rs11782328; rs16904373; rs17326567; rs2117692; rs16904394; rs263265; rs11778254; rs34572309; rs13278083; rs16929; rs4736465; rs989403; rs12334503; rs11777544; rs11989347; rs4131185; rs7000229; rs11780751; rs10088880; rs7841689; rs13265695; rs11782459; rs7838097; rs16904378; rs6415527; rs16904369; rs10103367; rs10956560; rs6984356; rs10100610; rs11784445; rs3833745; rs2304395; rs263270; rs2954689; rs7814878; rs7008910; rs7009510; rs4131186; rs16904370; rs6415526; rs7004930; rs7816914; rs11782951; rs11996141; rs10104692; rs11781972; rs10808586; rs16904395; rs11997256; rs16904386; rs11784937; rs16904398; rs7825741; rs7012204; rs16904366; rs6985687; rs16904372; rs17248420; rs12678370; rs6415521; rs16904356; rs12548651; rs5026643; rs10094213; rs10505568; rs11776888; rs11777147; rs11784784; rs174495; rs10111319; rs16904381; rs7009319; rs7461459; rs16904400; rs11998608; rs16904368; rs2954693; rs2164305; rs4403388; rs10956555; rs12547373; rs7845319; rs7002481; rs6998308; rs1509854; rs263247; rs11993878; rs11778567; rs1509856; rs1509855; rs11990557; rs7815654; rs13249674; rs4355788; rs11418327; rs11382893; rs34936684; rs34110742; rs3750886; rs35303855; rs34951827; rs6150817; rs28491358; rs5895059; rs34116734; rs34294045; rs34901430; rs13279731; rs10107328; rs10956557; rs36020360; rs35671214; rs28419668; rs28693644; rs28576995; rs6993336; rs11777293; rs34890820; rs13281804; rs34958539; rs17250143; rs35324849; rs34344106; rs5895063; rs34723108; rs35490866; rs3106092; rs34359920; rs35570520; rs34526776; rs5895075; rs35588945; rs10572208; rs13281814; rs34688343; rs1912273; rs1435445; rs35018594; rs7842857; rs35868088; rs10679053; rs35651333; rs10668266; rs3750887; rs35382013; rs5895066; rs11368798; rs36016316; rs28699083; rs35809897; rs34961824; rs9649966; rs28692964; rs35652412; rs10956559; rs34465511; rs35218184; rs11402511; rs12155610; rs3067432; rs35121882; rs13257796; rs7826283; rs33968868; rs35195692; rs368403; rs35843240; rs10481175; rs34193529; rs35123544; rs35177256; rs35261527; rs35086363; rs10611808; rs34478801; rs7461423; rs35272288; rs13267929; rs36076616; rs3922958; rs7833048; rs7463991; rs35874367; rs1329797; rs4612360; rs13279269; rs33998666; rs10659173; rs34070801; rs34339823; rs5895073; rs28687486; rs5895064; rs34673547; rs35028784; rs35714491; rs10585950; rs2149889; rs11426181; rs1435450; rs11459519; rs34195516; rs34393288; rs35755105; rs5742177; rs34050484; rs12549591; rs2026756; rs34815362; rs34697773; rs34424673; rs34885480; rs35799534; rs41356745; rs13264801; rs34009349; rs34659468; rs11315082; rs35027647; rs34564829; rs28452669; rs10571029; rs11331110; rs35199819; rs33998966; rs34829883; rs35779231; rs35647493; rs36109123; rs35699220; rs28380300; rs34721243; rs12334372; rs35234416; rs35721413; rs34853195; rs34131648; rs7820109; rs3922957; rs5895057; rs35848822; rs10611301; rs35810015; rs34805509; rs2376920; rs28508149; rs34427360; rs28525263; rs34608420; rs34659675; rs10607332; rs35806783; rs9694427; rs11443349; rs7464003; rs35007789; rs13269483; rs2664386; rs34163208; rs34200608; rs35806429; rs11446917; rs13271289; rs33915228; rs35578806; rs35161790; rs381196; rs4425774; rs34378349; rs5895069; rs12675824; rs7009806; rs401647; rs11268557; rs10956554; rs11410181; rs7836331; rs35392765; rs11367085; rs1160218; rs7010765; rs35104448; rs35266918; rs35357039; rs34250018; rs10637683; rs34152328; rs35140717; rs12334420; rs33958897; rs36028950; rs11783588; rs35981604; rs11406601; rs16904396; rs34085554; rs11368691; rs34922472; rs35231180; rs34556675; rs35146951; rs11785150; rs34976647; rs34346024; rs35687211; rs7011224; rs35026965; rs35000678; rs28404858; rs13281591; rs34163864; rs34057984; rs5895060; rs28621562; rs36185098; rs28485214; rs5895074; rs34938279; rs34059359; rs28751919; rs35633932; rs7460735; rs13251036; rs35551805; rs10098085; rs10956571; rs11785148; rs34559288; rs28803179; rs7836929; rs34055935; rs11417210; rs35042953; rs396105; rs10611300; rs28445446; rs10106144; rs13259311; rs7844745; rs10956558; rs35691280; rs10532518; rs36222610; rs34549758; rs34814893; rs28443477; rs11776259; rs33949474; rs35234466; rs10585951; rs3069786; rs34117777; rs12114354; rs13261396; rs35429212; rs10646748; rs13276850; rs959203; rs35919431; rs28373619; rs35904265; rs6993359; rs34088114; rs28577976; rs41543212; rs174494; rs2376921; rs36003888; rs34756934; rs3829031; rs10600050; rs28536655; rs35050296; rs34396484; rs7008094; rs34660831; rs10113476; rs13439383; rs35630768; rs1435448; rs10102467; rs11410180; rs34620076; rs1836631; rs13269356; rs35960116; rs2376919; rs28608189; rs34168179; rs11782721; rs12334512; rs35720678; rs35098464; rs28416041; rs35651136; rs5895072; rs34706837; rs34190963; rs34520718; rs35361060; rs28561486; rs10101829; rs35011711; rs34756612; rs6989230; rs10098561; rs36003544; rs34435115; rs5895067; rs925302; rs34048766; rs35571186; rs35694371; rs34716949; rs4736721; rs2117693; rs5026641; rs35408625; rs12155612; rs5000695; rs6982297; rs35763225; rs4407864; rs13277599; rs2664387; rs5895056; rs34522522; rs10594365; rs11988070; rs35814736; rs10103536; rs11438172; rs34117152; rs34950289; rs2007585; rs10578092; rs2149888; rs1329799; rs35408406; rs13277393; rs2917057; rs35816361; rs10090383; rs13340576; rs7843816; rs10102253; rs35642429; rs34853308; rs34544572; rs7838092; rs33934700; rs11279618; rs1576393; rs34269716; rs35009769; rs34441407; rs6997371; rs35633852; rs34676782; rs10100580; rs6995252; rs34473088; rs10594659; rs34680197; rs34238082; rs35069411; rs34341601; rs11776304; rs35701871; rs34024084; rs28469094; rs35450519; rs34352716; rs10645659; rs3922956; rs2026755; rs7008162; rs7835441; rs35033244; rs6985332; rs7465363; rs34421903; rs11417942; rs13250629; rs34751886; rs13262935; rs35984256; rs2664391; rs10956556; rs34184592; rs7836440; rs5895058; rs6992872; rs33949958; rs2572867; rs34633756; rs34421092; rs34808090; rs34057975; rs34900105; rs34774510; rs35457775; rs34700138; rs34737856; rs33927785; rs11407452; rs5895061; rs5895068; rs35392628; rs13269042; rs12682647; rs34093565; rs3891528; rs35202963; rs7831511; rs34390199; rs10435556; rs10435557; rs10505564; rs10956546; rs11785068; rs11787356; rs13258256; rs1509852; rs1509853; rs16904354; rs16904402; rs17225390; rs17330071; rs263244; rs6470852; rs6997501; rs7000140; rs7007094; rs7010990; rs7014884; rs7015398; rs7814990; rs7829589; rs7831104; rs7844356; rs7845976

# Metabolic_Enzyme_13_General_References:
8076676; 1715695

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5902

# Metabolic_Enzyme_14_Name:
High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

# Metabolic_Enzyme_14_Synonyms:
HSPDE8B

# Metabolic_Enzyme_14_Gene_Name:
PDE8B

# Metabolic_Enzyme_14_Protein_Sequence:
>Highaffinity cAMPspecific and IBMXinsensitive 3',5'cyclic phosphodiesterase 8
BMGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRAS
GPPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAE
VRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEI
IVIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFM
ENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFE
RMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHV
KITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESID
VKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVL
EILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPIT
INDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRA
WFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDH
PGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQA
IIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC
ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY
FITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS

# Metabolic_Enzyme_14_Number_of_Residues:
885

# Metabolic_Enzyme_14_Molecular_Weight:
98980

# Metabolic_Enzyme_14_Theoretical_pI:
6.81

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  two-component response regulator activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  signal transducer activity
Function:  catalytic activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
Process:  two-component signal transduction system (phosphorelay)
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Signal transduction mechanisms 

# Metabolic_Enzyme_14_Specific_Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase has high affinity for cAMP and may be involved in specific signaling in the thyroid gland

# Metabolic_Enzyme_14_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_14_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00989:PAS;
PF08629:PDE8;
PF00233:PDEase_I;
PF00072:Response_reg

# Metabolic_Enzyme_14_Signals:
None

# Metabolic_Enzyme_14_Transmembrane_Regions:
None

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_14_GenBank_ID_Protein:
32261241

# Metabolic_Enzyme_14_SwissProt_ID:
PDE8B_HUMAN (O95263)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
PDE8B

# Metabolic_Enzyme_14_Geneatlas_id:
PDE8B

# Metabolic_Enzyme_14_hgnc_id:
HGNC:8794

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_14_Gene_Sequence:
>2517 bp
ATGGGCTGCGCCCCCAGCATCCATGTCTCGCAGAGCGGCGTGATCTACTGCCGGGACTCG
GACGAGTCCAGCTCGCCCCGCCAGACCACCAGCGTGTCGCAGGGCCCGGCGGCACCCCTG
CCCGGCCTCTTCGTCCAGACCGACGCCGCCGACGCCATCCCCCCGAGCCGCGCGTCGGGA
CCCCCCAGCGTAGCCCGCGTCCGCAGGGCCCGCACCGAGCTGGGCAGCGGTAGCAGCGCG
GGTTCCGCAGCCCCCGCCGCGACCACCAGCAGGGGCCGGAGGCGCCACTGCTGCAGCAGC
GCCGAGGCCGAGACTCAGACCTGCTACACCAGCGTGAAGCAGGTGTCTTCTGCGGAGGTG
CGCATCGGGCCCATGAGACTGACGCAGGACCCTATTCAGGTTTTGCTGATCTTTGCAAAG
GAAGATAGTCAGAGCGATGGCTTCTGGTGGGCCTGCGACAGAGCTGGTTATAGATGCAAT
ATTGCTCGGACTCCAGAGTCAGCCCTTGAATGCTTTCTTGATAAGCATCATGAAATTATT
GTAATTGATCATAGACAAACTCAGAACTTCGATGCAGAAGCAGTGTGCAGGTCGATCCGG
GCCACAAATCCCTCCGAGCACACGGTGATCCTCGCAGTGGTTTCGCGAGTATCGGATGAC
CATGAAGAGGCGTCAGTCCTTCCTCTTCTCCACGCAGGCTTCAACAGGAGATTTATGGAG
AATAGCAGCATAATTGCTTGCTATAATGAACTGATTCAAATAGAACATGGGGAAGTTCGC
TCCCAGTTCAAATTACGGGCCTGTAATTCAGTGTTTACAGCATTAGATCACTGTCATGAA
GCCATAGAAATAACAAGCGATGACCACGTGATTCAGGAGTGGCAGGGGGTTTACTATGCC
AGACGGAAATCCGGGGACAGCATCCAACAGCACGTGAAGATCACCCCAGTGATTGGCCAA
GGAGGGAAAATTAGGCATTTTGTCTCGCTCAAGAAACTGTGTTGTACCACTGACAATAAT
AAGCAGATTCACAAGATTCATCGTGATTCAGGAGATAATTCTCAGACAGAGCCTCATTCA
TTCAGATATAAGAACAGGAGGAAAGAGTCCATTGACGTGAAATCGATATCATCTCGAGGC
AGTGATGCACCAAGCCTGCAGAATCGTCGCTATCCGTCCATGGCGAGGATCCACTCCATG
ACCATCGAGGCTCCCATCACAAAGGTTATAAATATAATCAATGCAGCCCAAGAAAACAGC
CCAGTCACAGTAGCGGAAGCCTTGGACAGAGTTCTAGAGATTTTACGGACCACAGAACTG
TACTCCCCTCAGCTGGGTACCAAAGATGAAGATCCCCACACCAGTGATCTTGTTGGAGGC
CTGATGACTGACGGCTTGAGAAGACTGTCAGGAAACGAGTATGTGTTTACTAAGAATGTG
CACCAGAGTCACAGTCACCTTGCAATGCCAATAACCATCAATGATGTTCCCCCTTGTATC
TCTCAATTACTTGATAATGAGGAGAGTTGGGACTTCAACATCTTTGAATTGGAAGCCATT
ACGCATAAAAGGCCATTGGTTTATCTGGGCTTAAAGGTCTTCTCTCGGTTTGGAGTATGT
GAGTTTTTAAACTGTTCTGAAACCACTCTTCGGGCCTGGTTCCAAGTGATCGAAGCCAAC
TACCACTCTTCCAATGCCTACCACAACTCCACCCATGCTGCCGACGTCCTGCACGCCACC
GCTTTCTTTCTTGGAAAGGAAAGAGTAAAGGGAAGCCTCGATCAGTTGGATGAGGTGGCA
GCCCTCATTGCTGCCACAGTCCATGACGTGGATCACCCGGGAAGGACCAACTCTTTCCTC
TGCAATGCAGGCAGTGAGCTTGCTGTGCTCTACAATGACACTGCTGTTCTGGAGAGTCAC
CACACCGCCCTGGCCTTCCAGCTCACGGTCAAGGACACCAAATGCAACATTTTCAAGAAT
ATTGACAGGAACCATTATCGAACGCTGCGCCAGGCTATTATTGACATGGTTTTGGCAACA
GAGATGACAAAACACTTTGAACATGTGAATAAGTTTGTGAACAGCATCAACAAGCCAATG
GCAGCTGAGATTGAAGGCAGCGACTGTGAATGCAACCCTGCTGGGAAGAACTTCCCTGAA
AACCAAATCCTGATCAAACGCATGATGATTAAGTGTGCTGACGTGGCCAACCCATGCCGC
CCCTTGGACCTGTGCATTGAATGGGCTGGGAGGATCTCTGAGGAGTATTTTGCACAGACT
GATGAAGAGAAGAGACAGGGACTACCTGTGGTGATGCCAGTGTTTGACCGGAATACCTGT
AGCATCCCCAAGTCTCAGATCTCTTTCATTGACTACTTCATAACAGACATGTTTGATGCT
TGGGATGCCTTTGCACATCTACCAGCCCTGATGCAACATTTGGCTGACAACTACAAACAC
TGGAAGACACTAGATGACCTAAAGTGCAAAAGTTTGAGGCTTCCATCTGACAGCTAA

# Metabolic_Enzyme_14_GenBank_ID_Gene:
AY129948

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_14_Locus:
5q14.1

# Metabolic_Enzyme_14_SNPs:
rs335614; rs971647; rs40594; rs459366; rs1061405; rs3733953; rs460267; rs16874261; rs832790; rs1479564; rs2046045; rs1479594; rs1479563; rs251421; rs335605; rs335643; rs844274; rs335644; rs875214; rs1531615; rs832788; rs832787; rs1904441; rs141331; rs890717; rs251420; rs2242159; rs884162; rs1096752; rs832785; rs251419; rs1479600; rs1871467; rs10473990; rs3797462; rs6867654; rs3733952; rs1545774; rs7715119; rs7717046; rs12697864; rs10056404; rs9686527; rs12521494; rs163017; rs11739402; rs4704402; rs1382879; rs7720828; rs6863296; rs922540; rs11960749; rs6887019; rs4704403; rs10066037; rs1560024; rs6885282; rs335599; rs1479598; rs6885813; rs335640; rs6860843; rs4704410; rs1382893; rs6893108; rs6453304; rs1479565; rs10942816; rs6874493; rs10474498; rs7717216; rs251426; rs12523314; rs374003; rs12516568; rs4704412; rs6864050; rs2242160; rs6453298; rs6453305; rs11953611; rs7729842; rs7732963; rs7714529; rs7705337; rs251418; rs922539; rs181851; rs4704417; rs4704397; rs12697863; rs6864358; rs7731628; rs7727976; rs11738226; rs1124742; rs11949597; rs13160107; rs3101867; rs1382894; rs1545775; rs10064824; rs2359877; rs7728597; rs4704414; rs10036386; rs251422; rs2279095; rs7733908; rs6860674; rs6453299; rs251416; rs1479562; rs6885099; rs10061629; rs10066802; rs10942819; rs4704409; rs12187512; rs10942817; rs16874184; rs7703993; rs7707719; rs951275; rs90684; rs11951639; rs335638; rs11956168; rs3816609; rs9293713; rs4704408; rs9686526; rs10213867; rs17683162; rs11738541; rs7718685; rs6453302; rs12520862; rs10474500; rs17570409; rs6886144; rs9687206; rs11745130; rs11738313; rs7702192; rs2359875; rs16874127; rs2859576; rs4704399; rs16874252; rs13436203; rs2359876; rs11747913; rs6453303; rs398509; rs251425; rs10942815; rs10514095; rs11744930; rs6453300; rs1982661; rs4704411; rs2359797; rs7723920; rs13355167; rs181852; rs6453296; rs11738417; rs11750528; rs2619770; rs6887671; rs6884413; rs16874241; rs11742966; rs7719378; rs11741219; rs10514096; rs970114; rs6892518; rs9687030; rs11957189; rs4596357; rs11742730; rs4704400; rs17671296; rs11959854; rs13158658; rs2306344; rs9942368; rs3101866; rs11748011; rs12515504; rs13361710; rs11749728; rs4704416; rs6861787; rs10045589; rs7448368; rs11748861; rs1479596; rs11741458; rs13164603; rs723374; rs335597; rs11749079; rs13178853; rs2884816; rs2359874; rs2306345; rs13158164; rs4703730; rs7713259; rs10514098; rs12514694; rs12515498; rs7716880; rs1479567; rs251428; rs10076794; rs10474493; rs1351283; rs335598; rs1479597; rs11750342; rs6453297; rs251414; rs2242161; rs1351284; rs11750661; rs11950697; rs251429; rs11956845; rs10514099; rs13182395; rs2046046; rs4703731; rs2061909; rs2359872; rs12522076; rs6896093; rs17750669; rs7711488; rs12513677; rs335618; rs90682; rs9686502; rs11750710; rs251430; rs7706106; rs1962690; rs90683; rs1479595; rs17671243; rs2170021; rs11741983; rs7704000; rs6870257; rs335616; rs6873924; rs989758; rs10037599; rs10069775; rs12658216; rs6862335; rs251417; rs13159632; rs7732150; rs12516965; rs6453301; rs6881121; rs12514649; rs12188039; rs864109; rs11949070; rs1993945; rs335642; rs13179491; rs1871466; rs183142; rs13186963; rs17683175; rs12658665; rs12189200; rs13179191; rs7710193; rs6871774; rs12652928; rs1479601; rs6881859; rs1993946; rs410656; rs13167306; rs13186807; rs6897771; rs11738860; rs9293711; rs16874254; rs4470750; rs10474499; rs11742634; rs6882455; rs2279094; rs35317395; rs7723017; rs16874217; rs4703732; rs6884627; rs11955381; rs13183278; rs16874125; rs2127387; rs10942818; rs11958816; rs16874147; rs1479599; rs6887282; rs9293716; rs9293712; rs4704398; rs13166933; rs13179196; rs6859326; rs10085063; rs3214046; rs7724067; rs10045594; rs17570416; rs6875758; rs10037785; rs7724077; rs2359873; rs16874198; rs6877581; rs11744847; rs17750729; rs2011799; rs7721608; rs4704401; rs6453295; rs13180935; rs10043551; rs9784696; rs251427; rs13186178; rs12515919; rs11749959; rs10474497; rs11741955; rs251413; rs11740409; rs12188903; rs6867719; rs13356848; rs7702923; rs2306343; rs16874239; rs7702029; rs6870261; rs7710509; rs13163022; rs173706; rs12188035; rs7719566; rs10474496; rs4704413; rs251431; rs7726487; rs17570031; rs1971620; rs6897909; rs13182285; rs6883526; rs6888919; rs17671405; rs6866018; rs6865817; rs13159287; rs7726243; rs335615; rs16874258; rs395882; rs17671389; rs12514448; rs10055027; rs10474495; rs13167302; rs6870862; rs10074631; rs13436637; rs12655629; rs6879904; rs17750688; rs6896812; rs10038311; rs10805909; rs11748016; rs335639; rs3816608; rs384871; rs7710224; rs10474494; rs7709849; rs12519528; rs186753; rs10536220; rs35454325; rs3733956; rs3733954; rs3733955; rs2017194; rs35747735; rs13163675; rs35577468; rs12153049; rs7714995; rs4704404; rs7735605; rs34790629; rs28409208; rs34299034; rs5868866; rs7714678; rs10039955; rs35428698; rs35884509; rs11745026; rs10474501; rs4432867; rs35554951; rs989759; rs10589971; rs36123024; rs35500936; rs1075970; rs13179037; rs11342716; rs251423; rs33976034; rs34191327; rs12233968; rs10474491; rs35235250; rs10591556; rs36022309; rs34566085; rs6858922; rs4704405; rs3926515; rs4521449; rs10608700; rs35742497; rs34717093; rs7717513; rs35601934; rs34988409; rs12520774; rs34128451; rs35350477; rs35358557; rs35681195; rs35858417; rs7714055; rs28622161; rs12515456; rs7356782; rs10085113; rs251424; rs35094296; rs1678771; rs36015907; rs34047268; rs17570395; rs11294329; rs34098762; rs34208297; rs3217712; rs34818611; rs34990832; rs3031820; rs33948936; rs34014902; rs34156142; rs5868864; rs34885670; rs34414970; rs35345614; rs11395504; rs16874135; rs12153424; rs11429258; rs35966684; rs13179071; rs6892493; rs28681499; rs3031818; rs28710929; rs35022674; rs34802194; rs11746782; rs11295108; rs35070029; rs11351004; rs35116180; rs34537187; rs34646527; rs1678770; rs35065656; rs1479566; rs34923412; rs10053760; rs35315780; rs35794220; rs11959580; rs34650604; rs33989497; rs10538529; rs5868867; rs35232100; rs35318083; rs2127393; rs35382869; rs34744319; rs2011227; rs34891839; rs335641; rs34698234; rs11316141; rs34336462; rs34713301; rs992807; rs11291697; rs10570712; rs34595584; rs335620; rs34465374; rs35914326; rs2359798; rs35785414; rs11284931; rs28431869; rs35786402; rs35981544; rs10552319; rs34318585; rs35164635; rs36052225; rs28527260; rs35776739; rs34491745; rs35910383; rs34720163; rs12521742; rs10645799; rs6860861; rs2306342; rs35407074; rs33938742; rs9687054; rs35870926; rs34731275; rs6871708; rs335617; rs7726528; rs41361846; rs35749456; rs34999521; rs28684701; rs35812985; rs1479568; rs13176017; rs34047237; rs35330679; rs35596621; rs6883469; rs35327743; rs13184182; rs5868865; rs3101235; rs6888937; rs34079916; rs35814560; rs35864749; rs10054725; rs3087185; rs34282242; rs6866209; rs34721887; rs13170449; rs34215321; rs6873097; rs35635069; rs33982217; rs832789; rs6875032; rs34708007; rs6894516; rs35839801; rs35156526; rs11422456; rs10036431; rs34725176; rs11418983; rs35535651; rs34142462; rs989757; rs36012253; rs35049636; rs34634450; rs6884434; rs35105712; rs34161143; rs4704406; rs11351800; rs33935667; rs3101236; rs34478659; rs34868740; rs34295093; rs11750129; rs35571993; rs173705; rs36011566; rs13158646; rs34152352; rs13179039; rs10076967; rs35309506; rs5868868; rs34081668; rs35776933; rs36021489; rs10589970; rs35120441; rs34017471; rs13159463; rs13174807; rs35159916; rs35280028; rs11405343; rs10602643; rs10573022; rs34410098; rs7443262; rs35717428; rs34922408; rs34773470; rs13158363; rs34420432; rs35470878; rs951276; rs35287095; rs34667262; rs251415; rs13170957; rs3031840; rs35452272; rs5868861; rs13166828; rs11958889; rs35160422; rs6866832; rs10710933; rs5868863; rs4704407; rs10552320; rs34684475; rs34735760; rs34540880; rs13166832; rs34008487; rs34960472; rs35010340; rs17671075; rs35522982; rs12523516; rs6884022; rs35185692; rs35363643; rs34748700; rs11413850; rs3031815; rs35838065; rs36085912; rs34764404; rs34648561; rs10639131; rs35674495; rs9942364; rs36120983; rs13166110; rs953375; rs35689253; rs34089667; rs13183146; rs5868860; rs7730446; rs5868862; rs13179043; rs35262504; rs35174935; rs12523538; rs35201094; rs35997618; rs35295164; rs35798710; rs35028488; rs35515495; rs35812799; rs9763156; rs2884817; rs4133658; rs2619784; rs34034632; rs34093656; rs35449293; rs13178574; rs34937443; rs35968667; rs335619; rs12110072; rs34525889; rs35052848; rs1045094; rs1111991; rs11739698; rs12652987; rs1382880; rs14368; rs1580; rs16874264; rs17671842; rs1982658; rs1982659; rs2114950; rs251411; rs251412; rs2928173; rs2972333; rs2972336; rs3149; rs335621; rs335622; rs335623; rs335624; rs335625; rs335627; rs335628; rs335629; rs335630; rs335631; rs335632; rs335633; rs335634; rs335635; rs335636; rs34489686; rs35189891; rs35774719; rs3797461; rs3797632; rs3797633; rs3797634; rs4704396; rs4704421; rs6864606; rs6891339; rs6898325; rs7726419; rs7737666; rs922538; rs972629; rs974280

# Metabolic_Enzyme_14_General_References:
12372422; 12681444; 9784418

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5927

# Metabolic_Enzyme_15_Name:
cGMP-specific 3',5'-cyclic phosphodiesterase

# Metabolic_Enzyme_15_Synonyms:
CGB-PDE; cGMP-binding cGMP-specific phosphodiesterase

# Metabolic_Enzyme_15_Gene_Name:
PDE5A

# Metabolic_Enzyme_15_Protein_Sequence:
>cGMPspecific 3',5'cyclic phosphodiesterase
MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSVPGTPTRKISASEFDRPLRPIVVKDSEG
TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN

# Metabolic_Enzyme_15_Number_of_Residues:
875

# Metabolic_Enzyme_15_Molecular_Weight:
100014

# Metabolic_Enzyme_15_Theoretical_pI:
6.00

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Not Available

# Metabolic_Enzyme_15_Specific_Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP

# Metabolic_Enzyme_15_Pathway:
Not Available

# Metabolic_Enzyme_15_Reaction:
guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF01590:GAF;
PF00233:PDEase_I

# Metabolic_Enzyme_15_Signals:
None

# Metabolic_Enzyme_15_Transmembrane_Regions:
None

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 3.1.4.35

# Metabolic_Enzyme_15_GenBank_ID_Protein:
3420185

# Metabolic_Enzyme_15_SwissProt_ID:
PDE5A_HUMAN (O76074)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
PDE5A

# Metabolic_Enzyme_15_Geneatlas_id:
PDE5A

# Metabolic_Enzyme_15_hgnc_id:
HGNC:8784

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_15_Gene_Sequence:
>2628 bp
ATGGAGCGGGCCGGCCCCAGCTTCGGGCAGCAGCGACAGCAGCAGCAGCCCCAGCAGCAG
AAGCAGCAGCAGAGGGATCAGGACTCGGTCGAAGCATGGCTGGACGATCACTGGGACTTT
ACCTTCTCATACTTTGTTAGAAAAGCCACCAGAGAAATGGTCAATGCATGGTTTGCTGAG
AGAGTTCACACCATCCCTGTGTGCAAGGAAGGTATCAGAGGCCACACCGAATCTTGCTCT
TGTCCCTTGCAGCAGAGTCCTCGTGCAGATAACAGTGTCCCTGGAACACCAACCAGGAAA
ATCTCTGCCTCTGAATTTGACCGGCCTCTTAGACCCATTGTTGTCAAGGATTCTGAGGGA
ACTGTGAGCTTCCTCTCTGACTCAGAAAAGAAGGAACAGATGCCTCTAACCCCTCCAAGG
TTTGATCATGATGAAGGGGACCAGTGCTCAAGACTCTTGGAATTAGTGAAGGATATTTCT
AGTCATTTGGATGTCACAGCCTTATGTCACAAAATTTTCTTGCATATCCATGGACTGATA
TCTGCTGACCGCTATTCCCTGTTCCTTGTCTGTGAAGACAGCTCCAATGACAAGTTTCTT
ATCAGCCGCCTCTTTGATGTTGCTGAAGGTTCAACACTGGAAGAAGTTTCAAATAACTGT
ATCCGCTTAGAATGGAACAAAGGCATTGTGGGACATGTGGCAGCGCTTGGTGAGCCCTTG
AACATCAAAGATGCATATGAGGATCCTCGGTTCAATGCAGAAGTTGACCAAATTACAGGC
TACAAGACACAAAGCATTCTTTGTATGCCAATTAAGAATCATAGGGAAGAGGTTGTTGGT
GTAGCCCAGGCCATCAACAAGAAATCAGGAAACGGTGGGACATTTACTGAAAAAGATGAA
AAGGACTTTGCTGCTTATTTGGCATTTTGTGGTATTGTTCTTCATAATGCTCAGCTCTAT
GAGACTTCACTGCTGGAGAACAAGAGAAATCAGGTGCTGCTTGACCTTGCTAGTTTAATT
TTTGAAGAACAACAATCATTAGAAGTAATTTTGAAGAAAATAGCTGCCACTATTATCTCT
TTCATGCAAGTGCAGAAATGCACCATTTTCATAGTGGATGAAGATTGCTCCGATTCTTTT
TCTAGTGTGTTTCACATGGAGTGTGAGGAATTAGAAAAATCATCTGATACATTAACAAGG
GAACATGATGCAAACAAAATCAATTACATGTATGCTCAGTATGTCAAAAATACTATGGAA
CCACTTAATATCCCAGATGTCAGTAAGGATAAAAGATTTCCCTGGACAACTGAAAATACA
GGAAATGTAAACCAGCAGTGCATTAGAAGTTTGCTTTGTACACCTATAAAAAATGGAAAG
AAGAATAAAGTTATAGGGGTTTGCCAACTTGTTAATAAGATGGAGGAGAATACTGGCAAG
GTTAAGCCTTTCAACCGAAATGACGAACAGTTTCTGGAAGCTTTTGTCATCTTTTGTGGC
TTGGGGATCCAGAACACGCAGATGTATGAAGCAGTGGAGAGAGCCATGGCCAAGCAAATG
GTCACATTGGAGGTTCTGTCGTATCATGCTTCAGCAGCAGAGGAAGAAACAAGAGAGCTA
CAGTCGTTAGCGGCTGCTGTGGTGCCATCTGCCCAGACCCTTAAAATTACTGACTTTAGC
TTCAGTGACTTTGAGCTGTCTGATCTGGAAACAGCACTGTGTACAATTCGGATGTTTACT
GACCTCAACCTTGTGCAGAACTTCCAGATGAAACATGAGGTTCTTTGCAGATGGATTTTA
AGTGTTAAGAAGAATTATCGGAAGAATGTTGCCTATCATAATTGGAGACATGCCTTTAAT
ACAGCTCAGTGCATGTTTGCTGCTCTAAAAGCAGGCAAAATTCAGAACAAGCTGACTGAC
CTGGAGATACTTGCATTGCTGATTGCTGCACTAAGCCACGATTTGGATCACCGTGGTGTG
AATAACTCTTACATACAGCGAAGTGAACATCCACTTGCCCAGCTTTACTGCCATTCAATC
ATGGAACACCATCATTTTGACCAGTGCCTGATGATTCTTAATAGTCCAGGCAATCAGATT
CTCAGTGGCCTCTCCATTGAAGAATATAAGACCACGTTGAAAATAATCAAGCAAGCTATT
TTAGCTACAGACCTAGCACTGTACATTAAGAGGCGAGGAGAATTTTTTGAACTTATAAGA
AAAAATCAATTCAATTTGGAAGATCCTCATCAAAAGGAGTTGTTTTTGGCAATGCTGATG
ACAGCTTGTGATCTTTCTGCAATTACAAAACCCTGGCCTATTCAACAACGGATAGCAGAA
CTTGTAGCAACTGAATTTTTTGATCAAGGAGACAGAGAGAGAAAAGAACTCAACATAGAA
CCCACTGATCTAATGAACAGGGAGAAGAAAAACAAAATCCCAAGTATGCAAGTTGGGTTC
ATAGATGCCATCTGCTTGCAACTGTATGAGGCCCTGACCCACGTGTCAGAGGACTGTTTC
CCTTTGCTAGATGGCTGCAGAAAGAACAGGCAGAAATGGCAGGCCCTTGCAGAACAGCAG
GAGAAGATGCTGATTAATGGGGAAAGCGGCCAGGCCAAGCGGAACTGA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
AF043731

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_15_Locus:
4q25-q27

# Metabolic_Enzyme_15_SNPs:
rs3733526; rs17051276; rs11947234; rs6817975; rs4834789; rs10022664; rs4834790; rs4833622; rs6847164; rs17006190; rs7672961; rs6817738; rs10050092; rs4834788; rs6839165; rs4597811; rs11734241; rs6534146; rs11729521; rs11731568; rs13124532; rs4287988; rs2953294; rs6534145; rs2953293; rs3109370; rs12505735; rs4626181; rs6534147; rs1480938; rs28578366; rs12502511; rs11730798; rs6855918; rs6832740; rs17355550; rs8180147; rs28681016; rs7681796; rs6831062; rs1045177; rs2953290; rs4833620; rs2953295; rs2389885; rs4833621; rs17006236; rs7693919; rs7672519; rs6534148; rs13106925; rs28535956; rs1010740; rs2715021; rs2291185; rs1480939; rs2715018; rs1987179; rs1552095; rs1480940; rs1155576; rs1383532; rs2306456; rs2389869; rs1010739; rs3736115; rs7687843; rs7688802; rs2389866; rs3733523; rs11731756; rs11098531; rs12502423; rs11736416; rs12510138; rs12498599; rs11098532; rs3775844; rs3756157; rs7699064; rs2248236; rs12642735; rs13107334; rs3775847; rs12502389; rs2127822; rs3775854; rs9997631; rs10030660; rs3775852; rs12646525; rs2256645; rs1383533; rs10009626; rs7694856; rs2622499; rs2622500; rs10008791; rs4834779; rs1480933; rs13128602; rs3775845; rs6534140; rs6534139; rs10013305; rs1155577; rs2622496; rs2389868; rs7678400; rs2622497; rs2306455; rs3733520; rs1480936; rs6853998; rs2086450; rs13121569; rs10012485; rs13134665; rs3822191; rs7692994; rs12648259; rs2389863; rs3756156; rs2127823; rs11933966; rs10019674; rs3822194; rs10518333; rs3822192; rs7659250; rs10004484; rs11724055; rs3775856; rs2715020; rs10518336; rs3775848; rs7697823; rs10031665; rs3733525; rs3775843; rs10518335; rs6844263; rs7695620; rs10034450; rs10016736; rs3822190; rs3733524; rs3775858; rs7439678; rs3756155; rs17292047; rs13149407; rs7680748; rs7680063; rs7684899; rs3775846; rs17050695; rs12108288; rs17358524; rs11737395; rs17358860; rs9995026; rs4834784; rs13125819; rs7664986; rs4513554; rs3733521; rs3775850; rs1552092; rs11723090; rs2389864; rs2170276; rs13119104; rs3822193; rs3822195; rs7670921; rs10031483; rs3756154; rs10434031; rs2257018; rs6858592; rs7658561; rs3775851; rs3733519; rs4834787; rs6847818; rs6843229; rs2928991; rs7441716; rs10032392; rs10471013; rs6835635; rs34676199; rs6842674; rs17007201; rs4146266; rs10023384; rs4834786; rs10003953; rs13104219; rs11936555; rs2892869; rs7662636; rs6858777; rs6822275; rs13120581; rs10029882; rs2389867; rs11936841; rs7657515; rs17357499; rs12503853; rs11942898; rs6845402; rs3836705; rs9998919; rs17050700; rs10027735; rs9762527; rs10021460; rs4001175; rs2953292; rs2127827; rs12503809; rs12503898; rs7657849; rs17357002; rs3775842; rs10032993; rs9307478; rs2306457; rs1552094; rs3832310; rs11728616; rs2389870; rs10018280; rs10031328; rs17358475; rs3775841; rs6833334; rs12648182; rs17007576; rs17051261; rs1480934; rs2892867; rs2127826; rs10021823; rs12498539; rs13103899; rs6834347; rs9884402; rs4264816; rs2715022; rs11098533; rs17051262; rs6534141; rs6829903; rs2389865; rs9997423; rs12502531; rs17007472; rs7669520; rs2389871; rs3806808; rs17005698; rs6834796; rs13116789; rs35062994; rs2389884; rs11363700; rs10025536; rs13136462; rs35938775; rs8180145; rs10615829; rs28566610; rs10021469; rs28419430; rs9992502; rs11290659; rs35004652; rs6817317; rs13118388; rs13122502; rs5861435; rs7681980; rs10711029; rs35748413; rs35455771; rs13136296; rs35454723; rs34901236; rs35101570; rs34918444; rs12504983; rs28469881; rs34601943; rs1045157; rs35758637; rs11324618; rs35620864; rs28450144; rs35105657; rs35566617; rs35184157; rs34269739; rs34089664; rs3839163; rs33918643; rs34202789; rs12648652; rs28415331; rs10536068; rs11453574; rs35081967; rs10155235; rs35432148; rs35967840; rs35674158; rs9307480; rs11334790; rs10013852; rs3056860; rs3056797; rs5861432; rs11295209; rs10706998; rs34945097; rs35264119; rs13140497; rs11352066; rs34521874; rs3775849; rs35182804; rs13140391; rs35189456; rs28736368; rs36026032; rs3775855; rs11392885; rs35576199; rs3832309; rs4337718; rs35999787; rs33952829; rs3836709; rs2928994; rs33963018; rs11343673; rs34825792; rs28405434; rs28625289; rs36170021; rs5861429; rs10021318; rs10213498; rs35236680; rs35535411; rs35412284; rs9884290; rs12331661; rs2715015; rs34712759; rs34873286; rs5861431; rs11455919; rs2928995; rs34978491; rs28576329; rs35960124; rs35111518; rs3733522; rs35852479; rs10031926; rs10213673; rs36173322; rs28735358; rs13115778; rs33940010; rs28375929; rs13147578; rs35409170; rs41278071; rs34944084; rs36046509; rs36159601; rs11931723; rs13137511; rs7692325; rs34830431; rs34698887; rs41464847; rs28540362; rs4834783; rs28718422; rs35777352; rs35289699; rs7685157; rs34868248; rs34368241; rs10010096; rs35906047; rs5861433; rs5861434; rs34847681; rs2928992; rs7694813; rs36137103; rs28621505; rs34160653; rs10015714; rs35201113; rs34036667; rs12505618; rs33944872; rs4834782; rs12108603; rs28394116; rs12331968; rs28382361; rs12508098; rs33926198; rs7678973; rs11299247; rs12644001; rs35813548; rs11438089; rs28639494; rs13103510; rs10697082; rs13133969; rs4340778; rs35507637; rs2928993; rs34492508; rs2622501; rs2715019; rs34840968; rs35233299; rs28394320; rs17291073; rs10696044; rs10710194; rs28380652; rs35466933; rs28634062; rs35172283; rs6854072; rs28461667; rs13152138; rs10612127; rs33935566; rs3836706; rs35865360; rs35632964; rs2715016; rs11945344; rs35852065; rs36191671; rs10434030; rs34294229; rs10696018; rs9994195; rs34146690; rs9998244; rs33937429; rs3214947; rs34463475; rs33977085; rs41278067; rs35791145; rs3836707; rs34025740; rs36108275; rs34504999; rs4604044; rs4001176; rs35326039; rs2622495; rs7691391; rs34308924; rs28412979; rs28622960; rs28685688; rs34772207; rs35595874; rs36040693; rs36192830; rs34426121; rs11945339; rs34892273; rs34255091; rs13140409; rs28650385; rs2622498; rs35519053; rs34129926; rs10640351; rs9998095; rs9996803; rs10579225; rs10545059; rs34002300; rs34244089; rs35539932; rs13140150; rs2306458; rs9884862; rs34767405; rs3836710; rs35108769; rs17356245; rs36197915; rs36098810; rs2622503; rs4998488; rs5861430; rs34123358; rs35850447; rs34580725; rs3836708; rs35609470; rs34953413; rs28564258; rs4596225; rs2928996; rs2622502; rs33998714; rs13137618; rs33944547; rs722667; rs35361251; rs34473068; rs35151809; rs10028249; rs10641710; rs41278069; rs2892868; rs11289914; rs10003668; rs34910273; rs28678287; rs34575312; rs34309305; rs11356355; rs11269159; rs33990318; rs28590372; rs34347414; rs11297755; rs35585470; rs35298888; rs36195333; rs34672540; rs28626938; rs9307477; rs28372207; rs34804498; rs4146268; rs722668; rs1552093; rs11551967; rs36196342; rs1480935; rs10010097; rs12649367; rs5020222; rs34009787; rs34884781; rs33993326; rs36194561; rs28615474; rs34736985; rs11408932; rs3840504; rs33930936; rs34480487; rs33982542; rs11342908; rs13149629; rs28653590; rs2953291; rs35952089; rs10643383; rs10639733; rs11344214; rs35833768; rs10006525; rs10006706; rs10009566; rs10017842; rs11098530; rs11935596; rs11940028; rs11940549; rs12507964; rs12508504; rs13145352; rs2389878; rs4834792; rs6849171; rs6849561; rs7675276; rs7681544

# Metabolic_Enzyme_15_General_References:
9714779; 9716380; 9642111; 10393044; 12955149

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5908

# Metabolic_Enzyme_16_Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D

# Metabolic_Enzyme_16_Synonyms:
DPDE3; PDE43

# Metabolic_Enzyme_16_Gene_Name:
PDE4D

# Metabolic_Enzyme_16_Protein_Sequence:
>cAMPspecific 3',5'cyclic phosphodiesterase 4
DMEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPP
PPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCR
AMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQ
ANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNN
FAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHS
VSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKR
PMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRP
LTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLS
TPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVG
FKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGV
LLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPM
CDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPA
PDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIP
LDEQVEEEAVGEEEESQPEACVIDDRSPDT

# Metabolic_Enzyme_16_Number_of_Residues:
809

# Metabolic_Enzyme_16_Molecular_Weight:
91116

# Metabolic_Enzyme_16_Theoretical_pI:
5.25

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_16_Specific_Function:
Regulates the levels of cAMP in the cell

# Metabolic_Enzyme_16_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_16_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_16_Signals:
None

# Metabolic_Enzyme_16_Transmembrane_Regions:
None

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_16_GenBank_ID_Protein:
347130

# Metabolic_Enzyme_16_SwissProt_ID:
PDE4D_HUMAN (Q08499)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
PDE4D

# Metabolic_Enzyme_16_Geneatlas_id:
PDE4D

# Metabolic_Enzyme_16_hgnc_id:
HGNC:8783

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Cytoplasm. Membrane (By similarity). Cytoplasm; cytoskeleton (By similarity). Centrosome (By similarity). Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity)

# Metabolic_Enzyme_16_Gene_Sequence:
>2024 bp
ACATGATGCACGTGAATAATTTTCCCTTTAGAAGGCATTCCTGGATATGTTTTGATGTGG
ACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGC
TAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCG
ACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATA
TACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTG
TACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCAC
CCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAAC
TGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGA
CCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGTTTAAAAGGATGCTTAATCGGGAGC
TCACCCATCTCTCTGAAATGAGTCGGTCTGGAAATCAAGTGTCAGAGTTTATATCAAACA
CATTCTTAGATAAGCAACATGAAGTGGAAATTCCTTCTCCAACTCAGAAGGAAAAGGAGA
AAAAGAAAAGACCAATGTCTCAGATCAGTGGAGTCAAGAAATTGATGCACAGCTCTAGTC
TGACTAATTCAAGTATCCCAAGGTTTGGAGTTAAAACTGAACAAGAAGATGTCCTTGCCA
AGGAACTAGAAGATGTGAACAAATGGGGTCTTCATGTTTTCAGAATAGCAGAGTTGTCTG
GTAACCGGCCCTTGACTGTTATCATGCACACCATTTTTCAGGAACGGGATTTATTAAAAA
CATTTAAAATTCCAGTAGATACTTTAATTACATATCTTATGACTCTCGAAGACCATTACC
ATGCTGATGTGGCCTATCACAACAATATCCATGCTGCAGATGTTGTCCAGTCTACTCATG
TGCTATTATCTACACCTGCTTTGGAGGCTGTGTTTACAGATTTGGAGATTCTTGCAGCAA
TTTTTGCCAGTGCAATACATGATGTAGATCATCCTGGTGTGTCCAATCAATTTCTGATCA
ATACAAACTCTGAACTTGCCTTGATGTACAATGATTCCTCAGTCTTAGAGAACCATCATT
TGGCTGTGGGCTTTAAATTGCTTCAGGAAGAAAACTGTGACATTTTCCAGAATTTGACCA
AAAAACAAAGACAATCTTTAAGGAAAATGGTCATTGACATCGTACTTGCAACAGATATGT
CAAAACACATGAATCTACTGGCTGATTTGAAGACTATGGTTGAAACTAAGAAAGTGACAA
GCTCTGGAGTTCTTCTTCTTGATAATTATTCCGATAGGATTCAGGTTCTTCAGAATATGG
TGCACTGTGCAGATCTGAGCAACCCAACAAAGCCTCTCCAGCTGTACCGCCAGTGGACGG
ACCGGATAATGGAGGAGTTCTTCCGCCAAGGAGACCGAGAGAGGGAACGTGGCATGGAGA
TAAGCCCCATGTGTGACAAGCACAATGCTTCCGTGGAAAAATCACAGGTGGGCTTCATAG
ACTATATTGTTCATCCCCTCTGGGAGACATGGGCAGACCTCGTCCACCCTGACGCCCAGG
ATATTTTGGACACTTTGGAGGACAATCGTGAATGGTACCAGAGCACAATCCCTCAGAGCC
CCTCTCCTGCACCTGATGACCCAGAGGAGGGCCGGCAGGGTCAAACTGAGAAATTCCAGT
TTGAACTAACTTTAGAGGAAGATGGTGAGTCAGACACGGAAAAGGACAGTGGCAGTCAAG
TGGAAGAAGACACTAGCTGCAGTGACTCCAAGACTCTTTGTACTCAAGACTCAGAGTCTA
CTGAAATTCCCCTTGATGAACAGGTTGAAGAGGAGGCAGTAGGGGAAGAAGAGGAAAGCC
AGCCTGAAGCCTGTGTCATAGATGATCGTTCTCCTGACACGTAA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
L20970

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_16_Locus:
5q12

# Metabolic_Enzyme_16_SNPs:
rs7736186; rs702530; rs702531; rs10075508; rs10036063; rs10940636; rs829259; rs10035437; rs829260; rs17719258; rs3839219; rs12658211; rs1471430; rs35285; rs1961; rs702543; rs1374028; rs1824159; rs1014317; rs1391651; rs244574; rs383444; rs2607347; rs244593; rs992726; rs27727; rs159195; rs2910642; rs40125; rs2409625; rs1498599; rs35286; rs1867724; rs702544; rs1348710; rs1395336; rs27957; rs171800; rs258125; rs35260; rs455969; rs1348709; rs35309; rs258110; rs27183; rs40126; rs27548; rs1498611; rs27549; rs441817; rs2702372; rs37569; rs1445918; rs716908; rs372309; rs149084; rs27949; rs27170; rs35255; rs1031197; rs40122; rs35310; rs1445948; rs294485; rs35265; rs26701; rs244577; rs28054; rs2968012; rs2968019; rs149106; rs167161; rs1345793; rs153968; rs986067; rs35281; rs40215; rs37353; rs294478; rs154222; rs35262; rs2936190; rs2014012; rs35282; rs1391649; rs2968009; rs35279; rs1078368; rs26712; rs1559251; rs2910641; rs1471429; rs1038080; rs889231; rs294482; rs35289; rs28044; rs922434; rs424839; rs187716; rs2591825; rs2547917; rs2968015; rs1391650; rs37575; rs377451; rs35277; rs988828; rs525099; rs2968011; rs929820; rs670169; rs1838733; rs921942; rs181736; rs1345792; rs2968003; rs154224; rs26708; rs27184; rs35274; rs35280; rs26711; rs988827; rs765182; rs159196; rs26705; rs154223; rs1579846; rs2409629; rs11958956; rs1023814; rs185333; rs26694; rs1423308; rs370891; rs9968728; rs258105; rs3805554; rs6892369; rs9292197; rs7724713; rs244590; rs2168649; rs4700316; rs1445952; rs2968014; rs35278; rs7707541; rs6861969; rs10043357; rs6450505; rs294494; rs2702373; rs2968006; rs258109; rs27172; rs1541672; rs255648; rs2409630; rs6886495; rs1498600; rs11744761; rs433565; rs6886854; rs244587; rs187645; rs6450496; rs27898; rs244566; rs7727206; rs1823068; rs10059053; rs26700; rs3763083; rs427433; rs6874460; rs10062176; rs1553114; rs1824788; rs2409627; rs27547; rs2194210; rs26695; rs889229; rs10056754; rs1870077; rs11951359; rs7703022; rs153980; rs1990985; rs7703658; rs10061553; rs27395; rs10062397; rs4618401; rs37576; rs255650; rs294496; rs35287; rs10067048; rs6450521; rs153966; rs7700365; rs159197; rs7717802; rs35267; rs1874859; rs258128; rs7724786; rs997421; rs27171; rs2910643; rs10038704; rs26709; rs171801; rs1824154; rs401013; rs165940; rs736736; rs10052657; rs464311; rs6886791; rs6450502; rs4700328; rs256752; rs7728050; rs37572; rs244575; rs6861992; rs6893655; rs154031; rs9292200; rs1551938; rs2013979; rs294500; rs1156029; rs4551023; rs2968005; rs1156028; rs35258; rs1445947; rs26710; rs6875727; rs7723432; rs11952840; rs12654005; rs294483; rs6879949; rs172362; rs721826; rs6877743; rs10461656; rs26687; rs153978; rs7713369; rs244570; rs1947090; rs1817248; rs7712329; rs291122; rs6874089; rs6869400; rs1077183; rs7719441; rs4700317; rs1506557; rs7730070; rs10805513; rs10940644; rs6895685; rs2607343; rs10071163; rs1867711; rs27168; rs151802; rs154024; rs153982; rs12697177; rs35275; rs6450515; rs9292202; rs6450518; rs154028; rs6450512; rs255633; rs12697173; rs10041021; rs258107; rs37574; rs1350298; rs11746896; rs153985; rs1353748; rs9292195; rs1848060; rs10037973; rs258121; rs10062340; rs371775; rs10075104; rs291118; rs2968004; rs4700325; rs12697171; rs7443333; rs154025; rs2028842; rs13176291; rs378858; rs244573; rs2409631; rs6450498; rs153961; rs6883834; rs10064744; rs6887017; rs1457145; rs255649; rs7728286; rs2098699; rs1551564; rs10035950; rs2028836; rs40328; rs1553113; rs6897568; rs7735228; rs6877508; rs1862563; rs1445954; rs7735376; rs153979; rs149108; rs26688; rs1551939; rs4699932; rs244592; rs40444; rs1498601; rs1395337; rs27773; rs7734053; rs6450514; rs3852147; rs6450519; rs6867240; rs6450516; rs13356883; rs258111; rs4700315; rs6881054; rs1876209; rs244594; rs1457110; rs11957770; rs26714; rs7734070; rs244595; rs26715; rs6885378; rs6867053; rs12652499; rs378970; rs294484; rs244596; rs11958928; rs3805553; rs9292198; rs6877927; rs10066573; rs9283720; rs368538; rs181915; rs1345791; rs10223103; rs294492; rs392901; rs26689; rs1971061; rs1391648; rs244591; rs255647; rs12055306; rs1353749; rs7712076; rs6898374; rs7735572; rs1546221; rs1971940; rs10037958; rs37571; rs1445953; rs1035321; rs2702363; rs2112957; rs10940638; rs153981; rs6893668; rs10055769; rs464787; rs6870632; rs26702; rs10055954; rs2968018; rs35307; rs13328162; rs4699935; rs16889904; rs6450510; rs258112; rs35263; rs10040847; rs255557; rs256750; rs6450517; rs294497; rs17720639; rs16888990; rs10514861; rs16889611; rs13185828; rs1498608; rs11743194; rs27179; rs6450506; rs12518641; rs12655617; rs244571; rs3891334; rs10461657; rs11959801; rs16889427; rs974766; rs39672; rs7735570; rs7724814; rs10514864; rs1120303; rs4699941; rs10068543; rs11954668; rs16889885; rs6892860; rs153949; rs2607340; rs2936193; rs7729339; rs2591750; rs6896121; rs2591744; rs17797781; rs381755; rs13362239; rs10045879; rs10472081; rs10058478; rs1363882; rs9292205; rs7733296; rs10051287; rs10472105; rs11747104; rs13358738; rs10070436; rs2055297; rs17589766; rs9292186; rs295936; rs7701455; rs11740402; rs35259; rs6450522; rs428059; rs2547918; rs6869149; rs10065303; rs17528473; rs13155290; rs9292182; rs1874857; rs6891130; rs12186707; rs1838721; rs27175; rs10072367; rs6889851; rs7707392; rs6859139; rs27185; rs27695; rs2591749; rs13185063; rs17795692; rs28055; rs16889920; rs244581; rs17444185; rs244579; rs7712725; rs16889849; rs1909294; rs12514190; rs2081106; rs11738043; rs11952875; rs2081093; rs35305; rs2036220; rs13176475; rs7716276; rs16889805; rs154027; rs27181; rs35283; rs17589633; rs1813481; rs27187; rs10064893; rs433161; rs12109774; rs16889518; rs1541673; rs10471467; rs7717819; rs1960; rs4700314; rs7714707; rs10039312; rs187644; rs2034894; rs1823070; rs258106; rs255579; rs13160617; rs6450501; rs35284; rs13176940; rs2059191; rs11739293; rs13180599; rs6864156; rs255655; rs10472093; rs244582; rs1848059; rs27182; rs10069146; rs10065334; rs12697170; rs13354437; rs1975533; rs6888644; rs174039; rs11952011; rs17796734; rs35261; rs9292189; rs6867591; rs10041537; rs2216699; rs16889682; rs17528543; rs931855; rs37573; rs16888998; rs6450513; rs2547920; rs3816996; rs27174; rs6888474; rs10068836; rs12187079; rs10472106; rs16889508; rs1439; rs2055298; rs2702365; rs7714708; rs17528285; rs669240; rs17726292; rs258127; rs6450497; rs7703702; rs10085076; rs17721878; rs414746; rs16889796; rs17727615; rs4700321; rs2591748; rs10514871; rs11747413; rs2112910; rs11957827; rs10055095; rs4699939; rs6861842; rs10045878; rs11744488; rs209983; rs11951879; rs16889853; rs1115728; rs4321723; rs7717303; rs7719347; rs13355884; rs10075067; rs378869; rs16889280; rs16889907; rs244583; rs7723695; rs37579; rs9292185; rs12654485; rs27641; rs9292199; rs2591651; rs255652; rs10514863; rs10074854; rs17780175; rs2591826; rs13355401; rs10058672; rs2021384; rs1579848; rs2112956; rs294479; rs12517657; rs17444059; rs10471463; rs7733716; rs7730574; rs10471466; rs291119; rs487029; rs12656462; rs16889906; rs294491; rs10070294; rs10514860; rs6876934; rs651576; rs10038599; rs7737685; rs6871710; rs6862702; rs12657171; rs294481; rs12187448; rs12658554; rs2034893; rs13161623; rs7703452; rs573336; rs10472102; rs467300; rs16889874; rs11948651; rs6897015; rs16889512; rs7711639; rs11748392; rs6858946; rs16889175; rs6890598; rs697076; rs17778950; rs10058681; rs10461659; rs7707065; rs1542842; rs7701945; rs6896497; rs1605275; rs172363; rs11959132; rs10063540; rs6865647; rs1823066; rs13180690; rs10051847; rs42470; rs1105577; rs6891161; rs4700322; rs434422; rs10491352; rs9292188; rs27188; rs13361218; rs11957151; rs16889495; rs387647; rs6895550; rs193447; rs1498606; rs12518773; rs244568; rs294498; rs10491353; rs12658429; rs7730750; rs10514866; rs17782374; rs17776879; rs2441091; rs10073507; rs10055884; rs10065699; rs826435; rs16889883; rs10056637; rs10051191; rs6450509; rs12522563; rs153948; rs294476; rs12519611; rs16889129; rs17777413; rs16889248; rs6875867; rs17782969; rs27176; rs10071881; rs17796040; rs1395335; rs10514865; rs427748; rs7717821; rs16889810; rs11750426; rs7706227; rs427740; rs10514870; rs12514658; rs10058823; rs444552; rs10059709; rs17776825; rs1078369; rs1874858; rs244588; rs1445950; rs10044687; rs16889869; rs17780213; rs17780860; rs16889126; rs9292194; rs10056492; rs2968010; rs294474; rs950446; rs16889615; rs10043404; rs10038299; rs6450504; rs545611; rs2055296; rs10472082; rs6875027; rs4631140; rs17783275; rs26703; rs10440630; rs27178; rs10074426; rs10514862; rs10940642; rs9292206; rs1867725; rs13357758; rs9292184; rs17782238; rs35306; rs11948070; rs6892879; rs3805557; rs10036406; rs6858964; rs2968013; rs12653844; rs244580; rs6898269; rs6889456; rs10068809; rs6872134; rs6862564; rs11949561; rs10038855; rs17528634; rs17727092; rs7700870; rs2081092; rs13153653; rs6898082; rs2702369; rs12186633; rs3805556; rs16889412; rs3763084; rs425384; rs27670; rs13362115; rs2702371; rs35276; rs11960438; rs154221; rs255635; rs186078; rs7736808; rs10805515; rs27180; rs10058676; rs40216; rs918583; rs10079396; rs13160457; rs10036199; rs1457146; rs3901540; rs16889921; rs16889276; rs10077993; rs17443709; rs255654; rs7717248; rs11948356; rs1559252; rs6888028; rs10471465; rs17797996; rs16889876; rs6866342; rs6872808; rs17740767; rs454702; rs13162275; rs7735375; rs953302; rs10069009; rs389324; rs9918228; rs1457111; rs11738454; rs10077018; rs26704; rs244565; rs13173038; rs7715956; rs11949324; rs6871806; rs17723785; rs4479801; rs2059175; rs4699930; rs13355507; rs6896337; rs7707043; rs13189127; rs3903515; rs6894694; rs9918111; rs16889882; rs2547921; rs12656663; rs7728221; rs11956680; rs171729; rs10052856; rs6859693; rs6871410; rs10155628; rs17795596; rs10070295; rs1840838; rs16889912; rs153965; rs6884572; rs294503; rs10042425; rs16877155; rs13354210; rs17796824; rs6869578; rs6893986; rs11952435; rs13186012; rs17528453; rs6875497; rs17721311; rs697075; rs10073292; rs16889254; rs443191; rs11950805; rs1579845; rs10461660; rs11952527; rs1115729; rs13167220; rs16889908; rs294486; rs258123; rs6896519; rs7733300; rs9292193; rs244576; rs17741863; rs364528; rs7714403; rs10035390; rs11951025; rs17780740; rs13328175; rs682796; rs13362242; rs16889892; rs10940645; rs6876057; rs17719378; rs10472089; rs11955850; rs294499; rs9647533; rs10042606; rs931856; rs2968002; rs9918215; rs13189942; rs16889307; rs10514859; rs17528578; rs17777280; rs17721133; rs17722929; rs1644948; rs10043994; rs10061786; rs27532; rs2702375; rs12656132; rs2936201; rs13188077; rs13176997; rs10072637; rs6877740; rs7708183; rs1579849; rs2409628; rs2968001; rs16889901; rs1353747; rs34738; rs11749543; rs11954898; rs10077198; rs9687424; rs9292196; rs17528550; rs9292190; rs7729722; rs17725522; rs3805555; rs6877256; rs10056526; rs12521370; rs10472084; rs10055446; rs13177192; rs17720871; rs17721860; rs2409646; rs7726987; rs256120; rs6894618; rs7732124; rs11742439; rs958851; rs255651; rs6871017; rs10044336; rs12658004; rs922437; rs6892534; rs9292201; rs10039006; rs10058483; rs7707566; rs13357723; rs10042726; rs10472101; rs2409614; rs16889948; rs10062858; rs13187670; rs11747358; rs2061282; rs13360359; rs7716261; rs11956820; rs244586; rs17780584; rs16877169; rs17779217; rs1846369; rs10059809; rs291117; rs10042103; rs490105; rs6879216; rs13178514; rs258108; rs13360195; rs33927508; rs6870929; rs13154145; rs13361668; rs35308; rs7444432; rs950447; rs159194; rs13328174; rs16889167; rs2112959; rs13361223; rs1077978; rs6882204; rs13188962; rs4629551; rs2702361; rs10940640; rs10069187; rs17628114; rs11739354; rs10039990; rs6875884; rs17777617; rs2936199; rs7729776; rs17740749; rs10061320; rs1498609; rs1463816; rs10214048; rs13154828; rs2021776; rs1823067; rs380993; rs9918225; rs9292192; rs12522220; rs16889606; rs13165581; rs2968021; rs16889521; rs35288; rs244569; rs190433; rs1973450; rs4700335; rs16889919; rs10472107; rs12187317; rs16889274; rs153983; rs294477; rs403695; rs4699931; rs10155599; rs16889903; rs10051456; rs11955452; rs10070138; rs258120; rs1947095; rs6872107; rs16889913; rs10062986; rs34739; rs5010782; rs244585; rs387997; rs1108916; rs1909295; rs26713; rs10035257; rs6868963; rs10037978; rs419953; rs2161513; rs10035719; rs2936202; rs17528257; rs10040394; rs391377; rs2607349; rs149506; rs573230; rs7710479; rs244597; rs10055869; rs7704805; rs2702377; rs294495; rs13355229; rs16889484; rs11950544; rs35266; rs16889865; rs466978; rs11738525; rs1974839; rs17528522; rs6450520; rs403687; rs10063703; rs6890168; rs4700318; rs1532520; rs7701758; rs10068715; rs12521279; rs36064814; rs7713345; rs7719732; rs6874473; rs4326095; rs13183985; rs16889392; rs13328160; rs10155544; rs10940641; rs10052063; rs10065078; rs6870927; rs4395595; rs1463817; rs10045258; rs168641; rs17796399; rs6883494; rs153967; rs17776777; rs12186492; rs434274; rs10042733; rs10452450; rs16889499; rs1902609; rs10065206; rs371398; rs2591751; rs11959567; rs10471470; rs7729912; rs10044298; rs28385324; rs3087748; rs16889925; rs17740844; rs11955845; rs17797601; rs12188859; rs13169097; rs12697174; rs2591747; rs10054429; rs10079544; rs34235034; rs380118; rs6895303; rs6891589; rs13190249; rs8180396; rs10064468; rs10079614; rs11957508; rs1379297; rs4699937; rs6883346; rs10051023; rs6897538; rs12108729; rs13358203; rs16877156; rs12188029; rs16889878; rs258122; rs13328226; rs7716975; rs931857; rs11747768; rs16889896; rs10059338; rs2021775; rs13164981; rs17724250; rs2059174; rs258104; rs11746579; rs27173; rs7711904; rs244584; rs16889696; rs6875906; rs403672; rs16889190; rs10043671; rs10036287; rs294501; rs17798241; rs10065540; rs17798319; rs10040395; rs17741233; rs9292181; rs17589745; rs9686835; rs255812; rs6876050; rs13173495; rs10039572; rs10067196; rs10472098; rs10038321; rs16889743; rs16889161; rs17721564; rs10042327; rs16889846; rs2702360; rs10155627; rs13354657; rs16889478; rs6881137; rs10075364; rs10214073; rs13161585; rs10061206; rs4395596; rs382411; rs2216687; rs16889733; rs17781354; rs6863716; rs10057278; rs374713; rs1160958; rs16889227; rs9918223; rs419744; rs4700329; rs291120; rs258129; rs40203; rs10065498; rs9687262; rs9716722; rs17728654; rs7736385; rs1598740; rs8180419; rs10035212; rs6897504; rs1902610; rs6874662; rs6892252; rs10075171; rs13174180; rs11746624; rs27189; rs9292187; rs154023; rs13362296; rs10077672; rs12656944; rs13178315; rs10060200; rs16889258; rs3815764; rs10078763; rs6891288; rs153969; rs2277014; rs11739601; rs17725949; rs35264; rs16889181; rs16889479; rs4469166; rs4618402; rs154026; rs168834; rs10053330; rs2291851; rs2936200; rs17720311; rs7735133; rs6450508; rs1498612; rs10078754; rs11744259; rs7706044; rs466376; rs2409626; rs7702291; rs27723; rs17780836; rs4699938; rs12655844; rs11950492; rs13160982; rs10071088; rs11959349; rs10472110; rs11956001; rs829258; rs17291089; rs11950495; rs1058458; rs17853590; rs17853589; rs1058459; rs35684984; rs35839600; rs12187668; rs34530754; rs35859095; rs34835493; rs3839217; rs3839218; rs10718401; rs35914743; rs34128632; rs34115255; rs922435; rs34848147; rs35818307; rs27186; rs10574102; rs1209433; rs13169163; rs11365445; rs28505532; rs2034895; rs28725359; rs6149040; rs35851251; rs649476; rs34677469; rs35617728; rs13162482; rs35860266; rs11365791; rs35776313; rs258117; rs11413392; rs1143233; rs33950471; rs34854664; rs34187013; rs35879110; rs211670; rs35244458; rs2409613; rs7727032; rs33976406; rs1871181; rs34207840; rs294480; rs35785066; rs10660174; rs35366471; rs10079826; rs10586960; rs28461689; rs16889366; rs34060514; rs33991327; rs11418242; rs34996240; rs11436951; rs35078554; rs2936197; rs34455241; rs11401918; rs7700296; rs10056649; rs34563226; rs1813483; rs10603279; rs36048558; rs2591743; rs35264771; rs11429076; rs2702362; rs34153401; rs34555936; rs447261; rs1867712; rs10045441; rs10656770; rs159393; rs34567562; rs374691; rs12517094; rs11305111; rs5868184; rs10682149; rs35798154; rs3061653; rs13165285; rs36227655; rs6882478; rs7716631; rs6880249; rs12659081; rs34058811; rs34126067; rs12521516; rs34154445; rs6886569; rs7734463; rs1202161; rs13171241; rs35731466; rs34984294; rs2409648; rs2936189; rs34935059; rs4558950; rs13170796; rs11383327; rs7737978; rs34726071; rs1075641; rs35098298; rs7723289; rs13184217; rs35011298; rs6864694; rs4513648; rs10536982; rs11444928; rs34296140; rs36019972; rs35561012; rs35182475; rs2936203; rs5868170; rs10693866; rs5868155; rs34492945; rs1974836; rs36226812; rs3061616; rs13176721; rs34863757; rs1498610; rs10056619; rs11448342; rs1143230; rs33969423; rs34222623; rs35643183; rs34682234; rs35037415; rs36121613; rs34924381; rs190486; rs5868182; rs35842486; rs35507986; rs13156498; rs35924466; rs35092276; rs2936191; rs3989138; rs10472097; rs11447857; rs13177495; rs34301317; rs34696511; rs10581563; rs295934; rs10563874; rs5868157; rs2001663; rs34033893; rs34118182; rs34733788; rs34838287; rs34660223; rs28568571; rs28688372; rs35238877; rs7701039; rs3061422; rs13165299; rs34596458; rs35985169; rs3060393; rs34138345; rs34991840; rs34493562; rs13358946; rs4604141; rs35802681; rs28427182; rs35854938; rs34714025; rs1840846; rs10626836; rs17444108; rs3061651; rs2409645; rs34310135; rs13359304; rs10587602; rs244567; rs34120574; rs7700594; rs458953; rs7731885; rs13179931; rs2702364; rs3061709; rs35613781; rs34091391; rs33952315; rs34508989; rs35205837; rs1038079; rs35260023; rs34651837; rs11746156; rs5868167; rs34523714; rs34074485; rs977465; rs35035421; rs33915770; rs34756714; rs13357070; rs34505227; rs7731299; rs34047116; rs7445308; rs28403116; rs35338151; rs34172825; rs34418802; rs35926698; rs10672523; rs13154098; rs35376564; rs166261; rs34339765; rs2591752; rs13178411; rs1973451; rs28696115; rs17528223; rs34612377; rs35425879; rs6898554; rs34234985; rs10053177; rs35406293; rs2291852; rs7723589; rs35238842; rs34018147; rs1974840; rs34088870; rs28595613; rs255459; rs13159623; rs722010; rs35119819; rs1143231; rs185320; rs4426880; rs13359998; rs13171236; rs4619980; rs28713675; rs35883616; rs5868186; rs381332; rs28372523; rs36228173; rs13189436; rs34571539; rs34740; rs35047246; rs11461880; rs35450213; rs35253855; rs34686327; rs35126822; rs34685247; rs17443688; rs34086576; rs10472091; rs13190508; rs2547919; rs7738023; rs13157164; rs34990310; rs34269653; rs11371708; rs5868177; rs36172625; rs3061656; rs34308828; rs35455534; rs2607345; rs13159548; rs187368; rs13157341; rs4700323; rs1824157; rs1075640; rs35021239; rs1031198; rs3061658; rs35903843; rs13156940; rs11338647; rs13187400; rs2054443; rs3061710; rs34235697; rs3061308; rs35151567; rs440664; rs34472588; rs36088481; rs1813482; rs7711649; rs34084892; rs13360916; rs10572313; rs11349021; rs34207293; rs5868174; rs28424104; rs7715430; rs33940460; rs294502; rs13354612; rs7713258; rs5868152; rs36027270; rs3060391; rs10562385; rs28647633; rs35687752; rs7735196; rs35969214; rs10078108; rs36003579; rs33946616; rs7712922; rs2898243; rs432879; rs13362039; rs28620612; rs35979851; rs27691; rs35491995; rs10058612; rs13178256; rs10617961; rs35622981; rs35490549; rs11412067; rs35651411; rs185417; rs35939103; rs6884220; rs35476254; rs35234690; rs34662839; rs41405750; rs7713801; rs35584387; rs27169; rs35127834; rs34298707; rs11954741; rs34598563; rs35656102; rs34575207; rs34551750; rs13170793; rs35855221; rs35895437; rs3061409; rs34422101; rs13361043; rs34751449; rs35598166; rs35676156; rs2135480; rs36089178; rs4699936; rs28876414; rs35500271; rs34200989; rs13356176; rs3061708; rs10551360; rs6883912; rs28885736; rs6874847; rs1909296; rs35499758; rs7705352; rs35501358; rs2028841; rs35189950; rs28531774; rs13162317; rs173887; rs35943594; rs35339520; rs13184036; rs2968020; rs34379829; rs34769858; rs722923; rs7735649; rs34233597; rs28369243; rs35329504; rs13186000; rs2607341; rs6873109; rs258116; rs34624326; rs35259546; rs36072354; rs2607348; rs3061467; rs34344560; rs35448373; rs10035396; rs9716593; rs34680701; rs34453807; rs34593368; rs13179144; rs13328098; rs28648858; rs35735511; rs11373971; rs6871100; rs10063724; rs11955117; rs17797035; rs35227733; rs35304; rs7731607; rs17777238; rs36153134; rs34209888; rs33911877; rs13180196; rs258119; rs7713808; rs34533703; rs3061702; rs10040742; rs34501738; rs13158325; rs255656; rs431645; rs13159276; rs11351473; rs190432; rs10062189; rs35516422; rs35073004; rs34862762; rs34468745; rs35509503; rs34768031; rs35587177; rs33941389; rs6869945; rs35243888; rs2968016; rs10633205; rs2055295; rs1143236; rs35453725; rs11348414; rs3061706; rs6450503; rs3061457; rs35943112; rs13347326; rs35868304; rs35959609; rs35147554; rs6895251; rs33922784; rs35913935; rs28705844; rs7705784; rs34217990; rs10581664; rs7444132; rs2174624; rs5868163; rs1838720; rs10052704; rs10573988; rs35692333; rs34507601; rs11280004; rs34873380; rs255460; rs4441841; rs35943702; rs35966656; rs28571683; rs35925966; rs28735903; rs13163857; rs13177851; rs7710901; rs13178378; rs34209564; rs35365611; rs6149041; rs26686; rs34351758; rs35671080; rs6880654; rs154029; rs7710055; rs35190866; rs33949395; rs28490233; rs7735819; rs2607346; rs34621496; rs10070588; rs35836561; rs13187778; rs35343334; rs10471469; rs35526059; rs34709522; rs5868179; rs34649343; rs35231519; rs34555200; rs10699804; rs10041815; rs12188999; rs7737269; rs35954639; rs13181587; rs34314412; rs1506562; rs28508065; rs34879089; rs7737071; rs154220; rs10704376; rs6879049; rs13178988; rs35597897; rs7731419; rs9942415; rs6870989; rs34249657; rs10472095; rs5868168; rs11737993; rs34949154; rs28406753; rs35020719; rs1498607; rs3061415; rs34785566; rs745813; rs34276144; rs5868172; rs7717793; rs34592041; rs36157268; rs6877826; rs34084254; rs35818881; rs34669732; rs35063826; rs1472456; rs35069329; rs34248179; rs35027879; rs5868150; rs35837060; rs13154094; rs10472092; rs28529077; rs1350297; rs11420361; rs6875864; rs35399502; rs34554235; rs34907429; rs36034409; rs4700326; rs11948460; rs35459588; rs35553072; rs35979928; rs36074437; rs11325874; rs11953985; rs34017676; rs28415294; rs36098200; rs166260; rs35505239; rs16888929; rs9292191; rs10044159; rs10052007; rs10658576; rs34876197; rs176705; rs10041861; rs13358675; rs34131200; rs10472096; rs35653778; rs10641798; rs5868173; rs34683467; rs5868154; rs34275268; rs3061615; rs5868181; rs294475; rs34549454; rs35720109; rs35500652; rs34532597; rs34815381; rs166249; rs956180; rs10551181; rs10549903; rs34591489; rs10664902; rs531511; rs153984; rs153647; rs28430615; rs35326955; rs10079932; rs28544243; rs35500676; rs2112911; rs2936192; rs36121052; rs34681204; rs3061414; rs34943144; rs35494444; rs13175289; rs34715930; rs1143229; rs2702370; rs28429524; rs34211584; rs34992012; rs702545; rs11425003; rs34025440; rs34636836; rs4099231; rs35728243; rs7721436; rs13190507; rs34671126; rs34688238; rs34422882; rs12518035; rs531105; rs34206938; rs5868161; rs13181967; rs35194865; rs10085037; rs33953218; rs7709897; rs35838554; rs10434567; rs34521304; rs35496140; rs13177540; rs365223; rs35050580; rs10624686; rs12187491; rs36125698; rs36086955; rs7710053; rs258118; rs10471464; rs10626837; rs12108992; rs4700324; rs34457252; rs34449506; rs34490359; rs3061711; rs10085136; rs1143232; rs28657905; rs10595185; rs34098961; rs34550093; rs33951927; rs33964029; rs4699940; rs7711648; rs35355640; rs11744760; rs12110099; rs2409640; rs33945017; rs7707469; rs33923129; rs35342625; rs255634; rs7725632; rs13164719; rs34249117; rs35218911; rs922436; rs34795725; rs12514095; rs34539185; rs35356120; rs35388375; rs2044419; rs27722; rs1065494; rs528422; rs35473646; rs10587603; rs34797165; rs12522944; rs7443305; rs10641593; rs34734362; rs10717217; rs530656; rs34648106; rs35578341; rs1391652; rs11412476; rs10039838; rs10661060; rs13159605; rs1186170; rs10701223; rs35561822; rs13161215; rs7707404; rs10058671; rs10561334; rs34665636; rs4621516; rs7705360; rs12656432; rs34331472; rs35150172; rs5008690; rs34569783; rs35898879; rs2277013; rs383046; rs35182359; rs10223254; rs11324683; rs13179935; rs34433570; rs34156880; rs5868185; rs36203538; rs7443891; rs10533055; rs13359805; rs295933; rs34818966; rs5868171; rs11740671; rs10472090; rs11412487; rs33920644; rs2306292; rs1974841; rs28505210; rs34029569; rs6894319; rs12521263; rs11738599; rs34389985; rs13360907; rs6860418; rs35697600; rs13161103; rs2607344; rs5868176; rs7713069; rs34116835; rs10061600; rs34917776; rs36029168; rs28430839; rs34730535; rs10044993; rs10554068; rs682823; rs6891238; rs35187858; rs11366994; rs7712717; rs27177; rs10565535; rs16889147; rs12656961; rs28706428; rs7715622; rs611540; rs186079; rs13173458; rs34049029; rs13154123; rs35987304; rs35410510; rs11457080; rs1445951; rs37570; rs36131717; rs11955408; rs34206672; rs924998; rs5868164; rs11745169; rs34793823; rs35543326; rs35971368; rs11354852; rs17628143; rs35338164; rs33989667; rs10472087; rs34415724; rs7714489; rs434183; rs34085161; rs35163676; rs5868156; rs10707669; rs16889662; rs34615918; rs5868153; rs10056025; rs34029709; rs34252655; rs5868183; rs5868159; rs6892851; rs6896215; rs9717124; rs255653; rs35606632; rs28555377; rs28680208; rs1506558; rs11748888; rs34497390; rs11356537; rs6872782; rs34203891; rs6867393; rs1960757; rs34680150; rs7725779; rs28460862; rs34071921; rs35039897; rs6871694; rs34280879; rs36062192; rs34141079; rs1816081; rs35900836; rs35005183; rs13178213; rs34372825; rs34584672; rs34161581; rs34283365; rs7709565; rs34130701; rs2936196; rs34261138; rs9716000; rs258124; rs11447636; rs4379155; rs35516815; rs13162130; rs1870078; rs10461658; rs35251595; rs34842927; rs6890180; rs13158460; rs34183853; rs34298212; rs10076635; rs41447947; rs34297420; rs35948623; rs34729847; rs35112587; rs255458; rs12153416; rs35519507; rs36068157; rs11746769; rs4700320; rs2067346; rs12152794; rs10639186; rs33913249; rs13358027; rs10555061; rs10579840; rs1133158; rs35082015; rs34052142; rs34646492; rs34322052; rs34424874; rs35684548; rs11952286; rs35106150; rs1870076; rs7736448; rs36158560; rs34985394; rs5868169; rs35746970; rs5868166; rs10600245; rs35116914; rs10472100; rs256128; rs34054950; rs1457112; rs28513138; rs28562290; rs35131890; rs258114; rs258113; rs13185873; rs33937382; rs34060150; rs34916796; rs2702374; rs34357376; rs3061418; rs11952118; rs2607342; rs33993022; rs7715325; rs36030058; rs11387250; rs2548039; rs462930; rs35501009; rs34877183; rs10616440; rs35413991; rs35142413; rs35633619; rs36124270; rs10074406; rs34564012; rs34873866; rs13155404; rs34086583; rs34107557; rs34665834; rs34337000; rs10653014; rs10054481; rs34398584; rs34537847; rs34575928; rs10035258; rs10058539; rs10042414; rs34642374; rs28604386; rs6888386; rs13154271; rs6883563; rs12656245; rs5868175; rs6885690; rs12517745; rs13154277; rs35705115; rs35604134; rs10652340; rs28398197; rs466742; rs34265208; rs36014965; rs35585210; rs13186140; rs7341134; rs6450507; rs721784; rs258126; rs2591745; rs13161395; rs10648089; rs2702376; rs40121; rs28540859; rs35963925; rs12187338; rs35952598; rs611541; rs35797347; rs11738575; rs11350151; rs34092633; rs13358942; rs6149042; rs35450986; rs11346574; rs12516263; rs34285029; rs10698730; rs4627950; rs6898408; rs13185996; rs149107; rs7704141; rs34918657; rs11958824; rs7737908; rs10626977; rs35689772; rs34983709; rs35917605; rs1974838; rs10672522; rs10560642; rs11421072; rs3061408; rs35036216; rs35943533; rs12187142; rs10472088; rs11349022; rs11277625; rs34876134; rs10600503; rs7733370; rs35302311; rs10686252; rs34315041; rs36011948; rs185325; rs35273659; rs10556090; rs28660597; rs34506272; rs34254880; rs34072469; rs575045; rs35859105; rs7444519; rs12109436; rs12189022; rs34982318; rs954740; rs34256357; rs13179611; rs11949985; rs11953154; rs35801943; rs34306611; rs28862729; rs1664886; rs35950250; rs34024693; rs7733884; rs11952378; rs13359707; rs11413820; rs36080031; rs5868178; rs11951378; rs13181969; rs33910828; rs34629419; rs5868160; rs441683; rs7715975; rs34908081; rs28694209; rs3061472; rs7356672; rs34856947; rs4551022; rs34711969; rs6888059; rs35274311; rs34353158; rs36019773; rs35964845; rs28539646; rs10472094; rs1138029; rs28666954; rs13357540; rs13158346; rs4279300; rs3060388; rs7445460; rs10562252; rs13167988; rs13186015; rs34031021; rs1065495; rs35457740; rs3061466; rs7728853; rs258115; rs429191; rs13161214; rs7710342; rs36051277; rs10710659; rs5868151; rs1579316; rs6898386; rs34023059; rs10701279; rs10045150; rs34631941; rs11347219; rs9942390; rs35890577; rs34153724; rs28435484; rs6887956; rs34405862; rs35225834; rs11414841; rs34553923; rs34424978; rs1202160; rs10940639; rs10039319; rs6877904; rs36094087; rs7716117; rs28703107; rs13167038; rs35859367; rs35535163; rs5868180; rs34329719; rs34410141; rs13182805; rs1143234; rs35334435; rs34738106; rs7707973; rs35479721; rs9686434; rs35782047; rs13357023; rs35465707; rs6861588; rs9716677; rs1445949; rs28458370; rs11437091; rs12188697; rs694160; rs13171057; rs34683548; rs34220408; rs34129672; rs36013923; rs530284; rs1143235; rs6888675; rs28508224; rs34811771; rs34216373; rs11425439; rs34621078; rs3061713; rs13172552; rs11749523; rs35530997; rs1974837; rs1506560; rs35291504; rs10043736; rs10036938; rs35614028; rs34852844; rs34886659; rs3989118; rs28729916; rs13187814; rs3840338; rs35004795; rs34244304; rs4493634; rs10636912; rs34445163; rs28373501; rs1506559; rs12374472; rs10704375; rs13355311; rs10056445; rs41404047; rs1809012; rs28435556; rs549097; rs35716104; rs35148987; rs34763664; rs2572933; rs13180070; rs13157337; rs35770645; rs11302070; rs10546090; rs829257; rs36047924; rs11451313; rs11402131; rs10057562; rs1006431; rs10069162; rs10071774; rs10077740; rs10471462; rs10472078; rs10472079; rs10472080; rs10491440; rs10491441; rs10491442; rs11740523; rs11950308; rs12653432; rs12655332; rs12655347; rs13173189; rs13173224; rs13177216; rs13177592; rs13185339; rs13190178; rs13190308; rs1395334; rs1498602; rs1498603; rs1498604; rs1498605; rs17439074; rs17775453; rs1948651; rs1995166; rs2279737; rs295943; rs295944; rs295945; rs295946; rs295947; rs296404; rs296405; rs2968017; rs34791515; rs4143654; rs4279299; rs4699934; rs4700319; rs702521; rs702522; rs702524; rs702525; rs702526; rs702527; rs702528; rs7706419

# Metabolic_Enzyme_16_General_References:
8413254; 8797812; 8125310; 9371713; 10913353; 12834813; 14517540

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5982

# Metabolic_Enzyme_17_Name:
Adenylate cyclase type 9

# Metabolic_Enzyme_17_Synonyms:
Adenylate cyclase type IX; ATP pyrophosphate-lyase 9; Adenylyl cyclase 9

# Metabolic_Enzyme_17_Gene_Name:
ADCY9

# Metabolic_Enzyme_17_Protein_Sequence:
>Adenylate cyclase type 9
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDS
GGVPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYAL
FYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHL
PLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFV
MSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLN
DLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEK
KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVS
SGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKN
STKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI
REKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTF
ASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIR
MVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGS
AALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSER
NPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTK
IQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKE
CYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFE
FAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTT
GVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISP
DIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEE
RGRFGKAIEKDDCDETGIEEANELTKLNVSKSV

# Metabolic_Enzyme_17_Number_of_Residues:
1353

# Metabolic_Enzyme_17_Molecular_Weight:
150702

# Metabolic_Enzyme_17_Theoretical_pI:
7.35

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  phosphorus-oxygen lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  cyclic nucleotide biosynthesis
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Signal transduction mechanisms 

# Metabolic_Enzyme_17_Specific_Function:
May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin

# Metabolic_Enzyme_17_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_17_Reaction:
ATP = 3',5'-cyclic AMP + diphosphate

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF00211:Guanylate_cyc

# Metabolic_Enzyme_17_Signals:
None

# Metabolic_Enzyme_17_Transmembrane_Regions:
118-138
142-162
172-192
216-235
242-259
281-301
787-807
819-839
868-888
892-912
921-941
976-996

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 4.6.1.1

# Metabolic_Enzyme_17_GenBank_ID_Protein:
3138932

# Metabolic_Enzyme_17_SwissProt_ID:
ADCY9_HUMAN (O60503)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
ADCY9

# Metabolic_Enzyme_17_Geneatlas_id:
ADCY9

# Metabolic_Enzyme_17_hgnc_id:
HGNC:240

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Membrane; multi-pass membrane protein

# Metabolic_Enzyme_17_Gene_Sequence:
>3885 bp
ATGGCTTCCCCGCCCCACCAGCAGCTGCTGCATCACCACAGCACCGAGGTGAGCTGCGAC
TCCAGCGGGGACAGCAACAGCGTGCGCGTCAAGATCAACCCCAAGCAGCTGTCCTCCAAC
AGCCACCCCAAGCACTGCAAATACAGCATCTCCTCTAGCTGCAGCAGCTCTGGGGACTCC
GGGGGCGTCCCCCGGCGAGTGGGCGGCGGAGGCCGGCTGCGCAGGCAGAAGAAGCTGCCC
CAGCTGTTCGAGAGGGCCTCCAGCCGCTGGTGGGACCCCAAGTTCGACTCGGTGAACCTG
GAGGAGGCCTGCCTGGAGCGCTGCTTCCCGCAGACCCAGCGCCGGTTCCGGTATGCGCTC
TTCTACATCGGCTTCGCCTGCCTTCTGTGGAGCATCTATTTTGCGGTCCACATGAGATCC
AGACTGATCGTCATGGTCGCCCCCGCGCTGTGCTTCCTCCTGGTGTGTGTGGGCTTCTTT
CTGTTTACCTTCACCAAGCTGTACGCCCGGCATTACGCGTGGACCTCGCTGGCTCTCACC
CTGCTGGTGTTCGCCCTGACCCTGGCTGCGCAGTTCCAGGTCTTGACGCCTGTCTCAGGA
CGCGGCGACAGCTCCAACCTTACGGCCACAGCCCGGCCCACAGATACTTGCTTATCTCAA
GTGGGGAGCTTCTCCATGTGCATCGAAGTGCTCTTTTTGCTCTATACCGTCATGCACTTA
CCTTTGTACCTGAGTTTGTGTCTGGGGGTGGCCTACTCTGTCCTTTTCGAGACCTTTGGC
TACCATTTCCGGGATGAAGCCTGCTTCCCCTCGCCCGGAGCCGGGGCCCTGCACTGGGAG
CTGCTGAGCAGGGGGCTGCTCCACGGCTGCATCCACGCCATCGGGGTCCACCTGTTCGTC
ATGTCCCAGGTGAGGTCCAGGAGCACCTTCCTCAAGGTGGGGCAATCCATTATGCACGGG
AAGGACCTGGAAGTGGAAAAAGCCCTCAAAGAGAGGATGATTCATTCCGTGATGCCAAGA
ATCATAGCCGATGACTTAATGAAGCAGGGAGATGAGGAGAGTGAGAATTCTGTCAAGAGG
CATGCCACCTCGAGCCCCAAGAACAGGAAGAAAAAGTCTTCCATCCAAAAAGCTCCTATA
GCCTTCCGCCCTTTTAAGATGCAGCAGATCGAAGAAGTCAGTATTTTATTTGCAGATATC
GTGGGCTTCACCAAGATGAGTGCCAACAAGTCTGCCCACGCCCTGGTGGGTCTCCTGAAC
GATCTGTTCGGTCGCTTCGACCGCCTGTGTGAGGAGACCAAGTGTGAGAAAATCAGCACC
CTGGGAGACTGTTACTACTGCGTGGCGGGCTGTCCCGAGCCCCGGGCCGACCATGCCTAC
TGCTGCATCGAGATGGGCCTGGGCATGATCAAGGCCATCGAGCAGTTCTGCCAGGAGAAG
AAGGAGATGGTGAACATGAGAGTCGGGGTGCACACGGGCACCGTCCTTTGCGGCATCCTG
GGCATGAGGAGGTTTAAATTTGACGTGTGGTCCAACGATGTGAACCTGGCCAATCTCATG
GAGCAGCTGGGAGTGGCCGGCAAAGTTCACATTTCTGAGGCCACCGCAAAATACTTAGAT
GACCGGTACGAAATGGAAGATGGGAAAGTTATTGAACGGCTGGGCCAGAGCGTGGTTGCT
GACCAGTTGAAAGGTTTGAAGACATACCTGATATCGGGTCAGAGAGCCAAGGAGTCTCGC
TGCAGCTGTGCAGAGGCCTTGCTTTCTGGCTTTGAGGTCATTGACGGCTCACAGGTGTCC
TCAGGCCCTAGGGGACAGGGGACAGCGTCATCAGGGAATGTCAGTGACTTGGCGCAGACT
GTCAAAACCTTTGATAACCTTAAGACCTGCCCTTCGTGCGGAATCACATTTGCTCCCAAA
TCTGAAGCCGGCGCCGAGGGAGGAGCACCTCAAAACGGCTGCCAAGACGAGCATAAAAAC
AGCACCAAGGCTTCTGGAGGACCTAATCCCAAAACTCAGAACGGGCTCCTCAGCCCTCCC
CAAGAGGAGAAGCTCACCAACAGTCAGACTTCTCTGTGTGAGATCTTGCAGGAGAAGGGA
AGGTGGGCAGGGGTGAGCCTGGACCAGTCGGCTCTCCTTCCGCTGAGGTTCAAGAACATC
CGGGAGAAAACGGACGCCCACTTTGTGGACGTTATCAAAGAAGACAGCCTGATGAAAGAT
TACTTTTTTAAGCCGCCCATTAATCAGTTCAGCCTGAACTTCCTGGATCAGGAGCTGGAG
CGATCCTACAGGACCAGCTATCAGGAAGAGGTCATAAAGAACTCCCCCGTGAAGACGTTT
GCTAGTCCCACCTTCAGCTCCCTCCTGGATGTGTTTCTGTCGACCACAGTGTTTCTGACG
CTGTCCACCACCTGCTTCCTGAAGTACGAGGCGGCCACCGTGCCTCCCCCGCCCGCCGCC
CTGGCGGTCTTCAGTGCAGCCCTGCTGCTGGAGGTGCTGTCCCTCGCGGTGTCCATCAGG
ATGGTGTTCTTCCTGGAGGACGTCATGGCCTGCACCAAGCGCCTGCTGGAGTGGATCGCC
GGCTGGCTACCACGTCACTGCATCGGGGCCATCCTGGTGTCGCTTCCCGCACTGGCCGTC
TACTCCCATGTCACCTCCGAATATGAGACCAACATACACTTCCCAGTGTTCACAGGCTCG
GCCGCACTGATTGCCGTCGTGCACTACTGTAACTTCTGCCAGCTCAGCTCCTGGATGAGG
TCCTCCCTCGCCACCGTCGTGGGGGCCGGGCCGCTGCTCCTGCTCTACGTCTCCCTGTGC
CCAGACAGTTCTGTATTAACTTCGCCCCTTGACGCAGTACAGAATTTCAGTTCCGAGAGG
AACCCGTGCAATAGTTCGGTGCCGCGTGACCTCCGGCGGCCCGCCAGCCTCATCGGCCAG
GAGGTGGTTCTCGTCTTCTTTCTCCTGCTCTTGTTGGTCTGGTTCCTGAATCGCGAATTT
GAAGTCAGCTACCGCCTCCACTACCACGGAGACGTGGAAGCGGATCTTCACCGCACCAAG
ATCCAGAGCATGCGGGACCAGGCAGACTGGCTGCTGAGGAACATCATCCCCTACCACGTG
GCTGAGCAGCTGAAGGTGTCCCAGACCTACTCCAAGAACCACGACAGCGGAGGGGTGATC
TTCGCCAGCATCGTCAACTTCAGCGAGTTCTACGAGGAGAACTACGAGGGCGGCAAGGAG
TGCTACCGGGTCCTCAACGAGCTCATCGGGGACTTTGACGAGCTCCTAAGCAAGCCGGAC
TACAGCAGCATCGAGAAGATCAAGACCATCGGAGCCACGTACATGGCGGCGTCAGGGCTG
AACACCGCGCAGGCCCAGGACGGCAGCCACCCGCAGGAGCACCTGCAGATCCTGTTCGAG
TTCGCCAAGGAGATGATGCGCGTGGTGGACGACTTCAACAACAACATGCTGTGGTTCAAC
TTCAAGCTCCGCGTCGGCTTCAACCATGGGCCCCTCACGGCCGGGGTCATCGGCACCACC
AAGCTGCTGTACGACATCTGGGGAGACACCGTCAACATCGCCAGCAGGATGGACACCACC
GGCGTGGAGTGCCGCATCCAGGTGAGCGAAGAGAGCTACCGCGTCTTGAGCAAGATGGGC
TATGACTTCGACTACAGAGGGACCGTGAATGTCAAGGGGAAAGGCCAGATGAAGACCTAC
CTGTACCCAAAGTGCACGGATCACAGGGTCATCCCAGCACCAGCTGTCCATCTCCCCAGA
CATCCGCGTCCAGGTGGATGGCAGCATCGGACGGTCTCCCACAGACGAGATTGCCAACCT
GGTGCCTTCTGTCCAGTATGTGGACAAGACATCTCTGGGTTCTGA

# Metabolic_Enzyme_17_GenBank_ID_Gene:
AF036927

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_17_Locus:
16p13.3

# Metabolic_Enzyme_17_SNPs:
rs2230739; rs3730096; rs3730095; rs3730098; rs2230738; rs2240735; rs887248; rs3730099; rs3730094; rs3730138; rs2230742; rs2238434; rs879620; rs1045475; rs2531995; rs710893; rs2238435; rs879619; rs2238432; rs2530897; rs2238433; rs3730097; rs2239310; rs2601813; rs2531989; rs2531969; rs2601828; rs2531988; rs2532018; rs2531967; rs1967308; rs378200; rs2601777; rs405470; rs2072346; rs2238436; rs2239308; rs1967309; rs2239309; rs2072341; rs2601791; rs2238449; rs2531990; rs8052751; rs6500575; rs442611; rs4786459; rs2601807; rs2239304; rs2238438; rs731471; rs4785947; rs409963; rs7204987; rs11647828; rs2041245; rs2601775; rs2255499; rs4786452; rs2072342; rs7203542; rs2239305; rs2531985; rs2238439; rs3730129; rs3730128; rs432166; rs11076806; rs1075581; rs2107605; rs12595857; rs2601804; rs2283499; rs6500567; rs6500566; rs2072340; rs387212; rs2283497; rs730242; rs2531992; rs11076804; rs8045426; rs8048306; rs2532007; rs732099; rs2531963; rs7200397; rs2531964; rs6500576; rs2072339; rs3730136; rs11076803; rs2239311; rs2601831; rs2238455; rs2012244; rs8061182; rs7203833; rs2283494; rs7203473; rs3730124; rs4786456; rs8052906; rs2532020; rs437187; rs2531977; rs7193552; rs9922384; rs2532015; rs2601789; rs8061430; rs2238441; rs2108985; rs7185966; rs2531961; rs2023374; rs2239314; rs2531972; rs2540034; rs12924035; rs2532012; rs2079731; rs4786450; rs2907272; rs7196832; rs2532019; rs9936342; rs2601803; rs6500579; rs2238443; rs2256156; rs12103309; rs2283498; rs7190128; rs3827526; rs13380497; rs9935343; rs2239313; rs2283496; rs2238457; rs2601824; rs8064151; rs11865741; rs2531960; rs11647778; rs11643596; rs7189884; rs384067; rs933391; rs2601782; rs11862728; rs2526655; rs11647979; rs17136692; rs2531973; rs4786454; rs2239307; rs8052716; rs437115; rs3730126; rs7187955; rs3730119; rs11076800; rs17136751; rs2601796; rs887245; rs3730130; rs10852639; rs10775349; rs2239312; rs7193369; rs12917711; rs12935810; rs11862162; rs7204629; rs8044049; rs2238454; rs11647570; rs11076807; rs2531968; rs12448453; rs8059988; rs13338895; rs9935335; rs10775350; rs8054483; rs11649287; rs2041247; rs917522; rs2108987; rs933392; rs2532017; rs6500574; rs2531966; rs2238450; rs7198704; rs13380478; rs2601781; rs13338087; rs11866059; rs2531987; rs2601774; rs11645655; rs11076797; rs8047038; rs2283492; rs8053600; rs885696; rs11866933; rs2238437; rs1981644; rs10775351; rs1076375; rs2386825; rs11645435; rs2239315; rs12444920; rs6500577; rs2077628; rs9926586; rs2601785; rs11076802; rs2532010; rs2058166; rs11861128; rs7202049; rs388430; rs365010; rs7193439; rs2601814; rs3789035; rs6500572; rs9937255; rs11642371; rs9928721; rs2531986; rs12596300; rs12926615; rs8053258; rs8059217; rs441786; rs2386823; rs12449284; rs2386824; rs2601784; rs758445; rs7199235; rs12920508; rs1076376; rs2532022; rs11076801; rs2072338; rs12596379; rs2002487; rs7192040; rs2239306; rs3730131; rs2532004; rs11641844; rs2531982; rs2601808; rs8044973; rs7206387; rs2531974; rs4785949; rs12917625; rs2540031; rs887246; rs8054439; rs17256322; rs2601786; rs964606; rs6500569; rs2531979; rs4785953; rs17136722; rs17136755; rs2532008; rs8047603; rs4785950; rs450054; rs12149274; rs11076805; rs2531978; rs13337675; rs12445047; rs447361; rs12448223; rs6500573; rs445746; rs9928553; rs2601800; rs12930820; rs17136760; rs2601818; rs415760; rs2005816; rs2238452; rs12921697; rs11865421; rs12920521; rs3216335; rs383422; rs12148974; rs2532024; rs2238445; rs3730137; rs17199128; rs12599912; rs8056300; rs11866846; rs887244; rs12598562; rs11867090; rs2299669; rs17794327; rs17136733; rs12449039; rs1034905; rs2238446; rs12102614; rs7185765; rs2601817; rs2444217; rs441906; rs3730135; rs2601787; rs6500570; rs12925070; rs12102739; rs2601805; rs17136754; rs4785945; rs399218; rs12598529; rs2429376; rs17794435; rs9929383; rs8048111; rs758443; rs17256260; rs2530899; rs9925674; rs2159296; rs8056526; rs3789036; rs12599911; rs2238444; rs8063303; rs1981643; rs17136664; rs12149923; rs17136757; rs2238448; rs8046563; rs2072343; rs13338031; rs2532021; rs12927791; rs445844; rs6500568; rs12447540; rs8048845; rs8049452; rs6500578; rs17136720; rs1966381; rs1034906; rs12933423; rs6500571; rs2532016; rs17136707; rs8044213; rs12932927; rs17136643; rs2892143; rs1035098; rs2532011; rs408781; rs11642198; rs2531976; rs8048356; rs11076799; rs10221058; rs2531971; rs12598654; rs9934657; rs7190663; rs12599013; rs11861193; rs2530894; rs2532003; rs2530898; rs11543317; rs2241074; rs5815188; rs2531993; rs2531994; rs887247; rs7187345; rs11359; rs1045476; rs28360728; rs2601780; rs2238456; rs35146612; rs8049116; rs2247580; rs9932760; rs35608510; rs8055731; rs12149721; rs2601770; rs8060680; rs2238458; rs732100; rs35174890; rs34826380; rs34856142; rs2041246; rs7201496; rs34733913; rs2531983; rs7202825; rs34338298; rs2601792; rs34480288; rs9783799; rs12933455; rs9806845; rs2386828; rs13334369; rs7187649; rs34980572; rs2532005; rs11865449; rs34394487; rs2601823; rs2601827; rs12373028; rs12918648; rs9939172; rs4785944; rs34329295; rs12933665; rs12917816; rs34453134; rs35732229; rs8047620; rs2601799; rs35512625; rs35310083; rs11076796; rs12927585; rs449848; rs35845989; rs35904968; rs35527952; rs35635601; rs2238451; rs12931665; rs2601819; rs35158886; rs7499605; rs885697; rs12149798; rs2532009; rs12922685; rs34159566; rs767611; rs35961808; rs35326038; rs35007309; rs34447848; rs4786458; rs2532014; rs13380599; rs35290140; rs12934682; rs28618112; rs11644600; rs757603; rs9932552; rs35449509; rs1981641; rs35708815; rs5815191; rs36031332; rs34102747; rs35147648; rs34241332; rs28621914; rs28429509; rs35822370; rs9935306; rs34868358; rs34658527; rs34040332; rs35757833; rs34580217; rs12920928; rs2238447; rs35985396; rs12923006; rs28400309; rs13331972; rs28645979; rs34939979; rs2530900; rs12934564; rs34526475; rs8046986; rs35703127; rs34756033; rs35110342; rs34342028; rs2387052; rs446805; rs2283500; rs2526656; rs35710851; rs2601795; rs35228171; rs446395; rs36158163; rs8054159; rs34049101; rs12927227; rs34581716; rs12599913; rs3789034; rs35850245; rs2238440; rs34805235; rs2601812; rs34971636; rs34717869; rs34724133; rs11640042; rs8052990; rs35824715; rs1967306; rs12928813; rs9936555; rs34120900; rs9932121; rs35420325; rs7198128; rs9926483; rs34996948; rs35311127; rs34683841; rs35591676; rs28830263; rs2601820; rs35756805; rs8058659; rs35555696; rs35038759; rs2238442; rs4786453; rs12933557; rs35583899; rs2386827; rs28618126; rs34195370; rs2532025; rs35053928; rs36013667; rs12927926; rs2386826; rs13338828; rs2601829; rs454569; rs35993109; rs8056142; rs7187461; rs7198278; rs2601790; rs35905846; rs34479285; rs378024; rs35255896; rs34135751; rs2540032; rs34780093; rs2601825; rs7187022; rs34374759; rs407642; rs12446547; rs2531984; rs2601809; rs34140544; rs34007164; rs35847017; rs2601783; rs5815192; rs35010918; rs9938757; rs5815189; rs8057378; rs2601816; rs8055604; rs2526654; rs34658406; rs34904907; rs34522888; rs4785952; rs35025726; rs11644097; rs34476259; rs34552459; rs35359235; rs11645825; rs370222; rs2531975; rs34350481; rs34033929; rs34024991; rs34041178; rs2041248; rs34494341; rs35803770; rs41336654; rs8044170; rs35275983; rs12933558; rs12325363; rs12446889; rs35603837; rs34373077; rs11644379; rs28533716; rs34224958; rs4786455; rs34017599; rs28756748; rs34517526; rs35876774; rs12933077; rs35024069; rs2601801; rs8043565; rs2238453; rs1967307; rs9938497; rs2531970; rs2531980; rs28553505; rs12929944; rs34052874; rs12928814; rs35986924; rs35689012; rs35443157; rs36095645; rs35714728; rs2601793; rs9939108; rs2601811; rs35519397; rs35704240; rs34333292; rs34323482; rs35484150; rs34879590; rs35983934; rs34946291; rs34452343; rs35300888; rs11076798; rs12325377; rs10221072; rs35849494; rs2601826; rs34655185; rs28637835; rs28669037; rs28482206; rs34561705; rs12325124; rs2540033; rs4786451; rs12932993; rs34884657; rs35421077; rs35342676; rs8053479; rs2386829; rs2601778; rs5815190; rs36009151; rs28612091; rs2601798; rs2601821; rs2532006; rs34417887; rs8059483; rs28497761; rs34902787; rs8046166; rs28606577; rs2601815; rs34461960; rs35384844; rs2531991; rs12923825; rs34323189; rs34011616; rs36043329; rs4785951; rs34929116; rs12933412; rs34347577; rs2601830; rs2601822; rs11646996; rs35681254; rs2531962; rs28562961; rs2601802; rs35292084; rs34452085; rs2108986; rs34344577; rs34498621; rs8052241; rs2601806; rs35426745; rs12148963; rs13331349; rs8051478; rs34520063; rs12933567; rs28546902; rs12921565; rs34656025; rs34527175; rs13329947; rs35882017; rs34248797; rs28418410; rs34039133; rs7205175; rs5815193; rs35354324; rs34287895; rs9924094; rs2530895; rs13332171; rs34916596; rs11645015; rs9927767; rs34508900; rs2530896; rs35942809; rs11642708; rs10852640; rs11076808; rs11643436; rs11859595; rs11860974; rs12596136; rs1966419; rs1981642; rs2238424; rs2238425; rs2238426; rs2238427; rs2238428; rs2238429; rs2238431; rs2526295; rs2526296; rs2526297; rs2530891; rs2530892; rs2531999; rs2532001; rs2532002; rs2532013; rs2601779; rs2601788; rs422955; rs432814; rs7195913; rs7206142; rs8046007

# Metabolic_Enzyme_17_General_References:
9628827; 12972952; 9628581; 12168954

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5913

# Metabolic_Enzyme_18_Name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

# Metabolic_Enzyme_18_Synonyms:
GMP-PDE delta; p17 protein

# Metabolic_Enzyme_18_Gene_Name:
PDE6D

# Metabolic_Enzyme_18_Protein_Sequence:
>Retinal rod rhodopsinsensitive cGMP 3',5'cyclic phosphodiesterase subunit delta
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVS
RELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPA
SVLTGNVIIETKFFDDDLLVSTSRVRLFYV

# Metabolic_Enzyme_18_Number_of_Residues:
150

# Metabolic_Enzyme_18_Molecular_Weight:
17420

# Metabolic_Enzyme_18_Theoretical_pI:
5.35

# Metabolic_Enzyme_18_GO_Classification:
Not Available

# Metabolic_Enzyme_18_General_Function:
Not Available

# Metabolic_Enzyme_18_Specific_Function:
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate

# Metabolic_Enzyme_18_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_18_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF05351:GMP_PDE_delta

# Metabolic_Enzyme_18_Signals:
None

# Metabolic_Enzyme_18_Transmembrane_Regions:
None

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_18_GenBank_ID_Protein:
2896020

# Metabolic_Enzyme_18_SwissProt_ID:
PDE6D_HUMAN (O43924)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
PDE6D

# Metabolic_Enzyme_18_Geneatlas_id:
PDE6D

# Metabolic_Enzyme_18_hgnc_id:
HGNC:8788

# Metabolic_Enzyme_18_PDB_ID:
1KSG

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Not Available

# Metabolic_Enzyme_18_Gene_Sequence:
>453 bp
ATGTCAGCCAAGGACGAGCGGGCCAGGGAGATCCTGAGGGGCTTCAAACTAAATTGGATG
AACCTTCGGGATGCTGAGACAGGGAAGATACTCTGGCAAGGAACAGAAGACCTGTCTGTC
CCTGGTGTGGAGCATGAAGCCCGTGTTCCCAAGAAAATCCTCAAGTGCAAGGCAGTGTCT
CGAGAACTTAATTTTTCTTCGACAGAACAAATGGAAAAATTCCGCCTGGAACAAAAAGTT
TACTTCAAAGGGCAATGCCTAGAAGAATGGTTCTTCGAGTTTGGCTTTGTGATCCCTAAC
TCCACAAATACCTGGCAGTCCTTGATAGAGGCAGCACCCGAGTCCCAGATGATGCCAGCA
AGCGTCTTAACTGGGAACGTTATCATAGAAACAAAGTTTTTTGACGACGATCTTCTTGTA
AGCACATCCAGAGTGAGACTTTTCTATGTTTGA

# Metabolic_Enzyme_18_GenBank_ID_Gene:
AF045999

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_18_Locus:
2q35-q36

# Metabolic_Enzyme_18_SNPs:
rs8165; rs838447; rs1464974; rs838424; rs2570991; rs838448; rs6719408; rs7564574; rs838421; rs838446; rs6437035; rs6437036; rs4479418; rs1464976; rs865706; rs6727769; rs2340510; rs17271824; rs7564057; rs2693781; rs11682986; rs1055300; rs3912020; rs11691808; rs11886088; rs3748922; rs7578649; rs838459; rs1246073; rs838460; rs17271838; rs1986882; rs4973479; rs6729974; rs1246074; rs838442; rs838443; rs838423; rs4134454; rs4017857; rs838450; rs10208197; rs838445; rs10175192; rs16828383; rs11680005; rs11886978; rs2693782; rs10192111; rs11694559; rs1097849; rs17199642; rs1246072; rs11673810; rs1965569; rs865123; rs12466215; rs13425658; rs11687347; rs1097850; rs1464975; rs1246075; rs10174681; rs13412329; rs16828376; rs16828400; rs6437034; rs3830625; rs12468852; rs28364600; rs13424754; rs838425; rs35244888; rs838418; rs1246076; rs13388804; rs35193628; rs34916848; rs13017826; rs35427226; rs2340509; rs838444; rs35025339; rs11457200; rs2570994; rs34130127; rs3074725; rs34460175; rs1246067; rs6712578; rs866305; rs13392795; rs35343404; rs34916207; rs13020381; rs35633303; rs838420; rs2693778; rs838451; rs13416010; rs35413921; rs7574492; rs10164942; rs838415; rs3038045; rs13385970; rs36126237; rs11685411; rs10933382; rs34007857; rs34039711; rs13405908; rs34036079; rs838414; rs3887889; rs6745121; rs36043938; rs36094785; rs13412333; rs13029089; rs11413975; rs12620711; rs838449; rs12996166; rs1246069; rs2570990; rs34957131; rs36062317; rs34051193; rs35115820; rs955400; rs838417; rs13415801; rs3074722; rs13005798; rs1246068; rs34278996; rs34172773; rs838452; rs33924844; rs838416; rs7606479; rs12613234; rs838422; rs9973802; rs10168868; rs13020414; rs36006197; rs35042825; rs35145561; rs34036232; rs13417992; rs11679847; rs34089848; rs838419; rs13392965; rs13392413; rs838426; rs3210343; rs28642731; rs7607294; rs3210342; rs34031981; rs11557625; rs11682745; rs11689891; rs13392019; rs1554731; rs16825960; rs16828434; rs17199663; rs17271845; rs3748921; rs6437033; rs6732581; rs7598298; rs838427; rs838428; rs838429; rs838432

# Metabolic_Enzyme_18_General_References:
9570951; 9533031; 9781033; 10518933; 11980706

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5833

# Metabolic_Enzyme_19_Name:
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

# Metabolic_Enzyme_19_Synonyms:
GMP-PDE gamma

# Metabolic_Enzyme_19_Gene_Name:
PDE6H

# Metabolic_Enzyme_19_Protein_Sequence:
>Retinal cone rhodopsinsensitive cGMP 3',5'cyclic phosphodiesterase subunit gamma
MSDNTTLPAPASNQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVKGFGDDIPGMEGLGTDI
TVICPWEAFSHLELHELAQFGII

# Metabolic_Enzyme_19_Number_of_Residues:
83

# Metabolic_Enzyme_19_Molecular_Weight:
9074

# Metabolic_Enzyme_19_Theoretical_pI:
9.98

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  cGMP-specific phosphodiesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Not Available

# Metabolic_Enzyme_19_Specific_Function:
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones

# Metabolic_Enzyme_19_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_19_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF04868:PDE6_gamma

# Metabolic_Enzyme_19_Signals:
None

# Metabolic_Enzyme_19_Transmembrane_Regions:
None

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_19_GenBank_ID_Protein:
1311544

# Metabolic_Enzyme_19_SwissProt_ID:
CNCG_HUMAN (Q13956)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
PDE6H

# Metabolic_Enzyme_19_Geneatlas_id:
PDE6H

# Metabolic_Enzyme_19_hgnc_id:
HGNC:8790

# Metabolic_Enzyme_19_PDB_ID:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_19_Gene_Sequence:
>252 bp
ATGAGTGACAACACTACTCTGCCTGCTCCAGCTTCAAACCAGGGTCCTACCACCCCACGC
AAAGGCCCTCCCAAGTTCAAGCAGAGGCAGACTCGCCAATTCAAGAGTAAACCTCCAAAG
AAAGGTGTGAAAGGATTTGGAGATGACATTCCAGGAATGGAGGGGCTAGGAACAGATATC
ACAGTGATTTGTCCATGGGAGGCATTCAGCCACCTGGAATTGCATGAGCTCGCTCAGTTT
GGGATTATCTGA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
D45399

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_19_Locus:
12p13

# Metabolic_Enzyme_19_SNPs:
rs2233628; rs10846103; rs10505783; rs12305014; rs3748304; rs11056268; rs11056266; rs11056264; rs11056267; rs10505784; rs11056265; rs11832908; rs16910453; rs16910452; rs12228166; rs12422943; rs10744079; rs12306284; rs2233623; rs2233624; rs12832328; rs2233627; rs11833894; rs10846101; rs7954788; rs4764144; rs12579539; rs2233615; rs11835506; rs7953827; rs7301508; rs11056262; rs11056263; rs12228802; rs11611992; rs2233614; rs11450989; rs11314271; rs11346506; rs12817970; rs12817527; rs12822730; rs34043026; rs35679948; rs2233626; rs2233625; rs11608901; rs11608900; rs35657741; rs4616093; rs2233619; rs2233617; rs2233618; rs2233620; rs2233616; rs34917153; rs34417895; rs2233622; rs2233621; rs10744080; rs10846096; rs10846097; rs11056256; rs11056257; rs11056258; rs11056259; rs11056260; rs11056261; rs11056269; rs11056271; rs11056272; rs11056273; rs11056274; rs11056275; rs11832957; rs11834072; rs11835380; rs11835890; rs12298310; rs12298374; rs12307651; rs12308864; rs12322752; rs12424815; rs12425797; rs12425846; rs12426974; rs12821630; rs2024506; rs2430717; rs2430718; rs2430719; rs2430720; rs2430722; rs2445431; rs36114797; rs3983696; rs4429114; rs4764145; rs4764146; rs7300467; rs7301780; rs7311989; rs7313555; rs7954364; rs7954390; rs7955907; rs7966504; rs7968954; rs7976617; rs7977013; rs7978415

# Metabolic_Enzyme_19_General_References:
8786098

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
5884

# Metabolic_Enzyme_20_Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 7B

# Metabolic_Enzyme_20_Synonyms:
Not Available

# Metabolic_Enzyme_20_Gene_Name:
PDE7B

# Metabolic_Enzyme_20_Protein_Sequence:
>cAMPspecific 3',5'cyclic phosphodiesterase 7
BMSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTY
SGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDI
FLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAA
DVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNM
SVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLH
NKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEI
SPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPR
QHRSRGSSGSGPDHDHAGQGTESEEQEGDSP

# Metabolic_Enzyme_20_Number_of_Residues:
450

# Metabolic_Enzyme_20_Molecular_Weight:
51836

# Metabolic_Enzyme_20_Theoretical_pI:
7.03

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_20_General_Function:
Not Available

# Metabolic_Enzyme_20_Specific_Function:
May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain

# Metabolic_Enzyme_20_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_20_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_20_Signals:
None

# Metabolic_Enzyme_20_Transmembrane_Regions:
None

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_20_GenBank_ID_Protein:
8439497

# Metabolic_Enzyme_20_SwissProt_ID:
PDE7B_HUMAN (Q9NP56)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
PDE7B

# Metabolic_Enzyme_20_Geneatlas_id:
PDE7B

# Metabolic_Enzyme_20_hgnc_id:
HGNC:8792

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_20_Gene_Sequence:
>1353 bp
ATGTCTTGTTTAATGGTTGAGAGGTGTGGCGAAATCTTGTTTGAGAACCCCGATCAGAAT
GCCAAATGTGTTTGCATGCTGGGAGATATACGACTAAGGGGTCAGACGGGGGTTCGTGCT
GAACGCCGTGGCTCCTACCCATTCATTGACTTCCGCCTACTTAACAGTACAACATACTCA
GGGGAGATTGGCACCAAGAAAAAGGTGAAAAGACTATTAAGCTTTCAAAGATACTTCCAT
GCATCAAGGCTGCTTCGTGGAATTATACCACAAGCCCCTCTGCACCTGCTGGATGAAGAC
TACCTTGGACAAGCAAGGCATATGCTCTCCAAAGTGGGAATGTGGGATTTTGACATTTTC
TTGTTTGATCGCTTGACAAATGGAAACAGCCTGGTAACACTGTTGTGCCACCTCTTCAAT
ACCCATGGACTCATTCACCATTTCAAGTTAGATATGGTGACCTTACACCGATTTTTAGTC
ATGGTTCAAGAAGATTACCACAGCCAAAACCCGTATCACAATGCTGTTCACGCAGCCGAC
GTCACCCAGGCCATGCACTGCTACCTGAAAGAGCCAAAGCTTGCCAGCTTCCTCACGCCT
CTGGACATCATGCTTGGACTGCTGGCTGCAGCAGCACACGATGTGGACCACCCAGGGGTG
AACCAGCCATTTTTGATAAAAACTAACCACCATCTTGCAAACCTATATCAGAATATGTCT
GTGCTGGAGAATCATCACTGGCGATCTACAATTGGCATGCTTCGAGAATCAAGGCTTCTT
GCTCATTTGCCAAAGGAAATGACACAGGATATTGAACAGCAGCTGGGCTCCTTGATCTTG
GCAACAGACATCAACAGGCAGAATGAATTTTTGACCAGATTGAAAGCTCACCTCCACAAT
AAAGACTTAAGACTGGAGGATGCACAGGACAGGCACTTTATGCTTCAGATCGCCTTGAAG
TGTGCTGACATTTGCAATCCTTGTAGAATCTGGGAGATGAGCAAGCAGTGGAGTGAAAGG
GTCTGTGAAGAATTCTACAGGCAAGGTGAACTTGAACAGAAATTTGAACTGGAAATCAGT
CCTCTTTGTAATCAACAGAAAGATTCCATCCCTAGTATACAAATTGGTTTCATGAGCTAC
ATCGTGGAGCCGCTCTTCCGGGAATGGGCCCATTTCACGGGTAACAGCACCCTGTCGGAG
AACATGCTGGGCCACCTCGCACACAACAAGGCCCAGTGGAAGAGCCTGTTGCCCAGGCAG
CACAGAAGCAGGGGCAGCAGTGGCAGCGGGCCTGACCACGACCACGCAGGCCAAGGGACT
GAGAGCGAGGAGCAGGAAGGCGACAGCCCCTAG

# Metabolic_Enzyme_20_GenBank_ID_Gene:
AB038040

# Metabolic_Enzyme_20_Chromosome_Location:
Not Available

# Metabolic_Enzyme_20_Locus:
Not Available

# Metabolic_Enzyme_20_SNPs:
Not Available

# Metabolic_Enzyme_20_General_References:
10814504; 10872825

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
5862

# Metabolic_Enzyme_21_Name:
High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A

# Metabolic_Enzyme_21_Synonyms:
HCP1; TM22

# Metabolic_Enzyme_21_Gene_Name:
PDE7A

# Metabolic_Enzyme_21_Protein_Sequence:
>Highaffinity cAMPspecific 3',5'cyclic phosphodiesterase 7
AMEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQT
ALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLR
SSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFS
LHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTP
WDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLF
SHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALK
CADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTY
LVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQEN
RLS

# Metabolic_Enzyme_21_Number_of_Residues:
482

# Metabolic_Enzyme_21_Molecular_Weight:
55506

# Metabolic_Enzyme_21_Theoretical_pI:
7.53

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Not Available

# Metabolic_Enzyme_21_Specific_Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase is highly specific for cAMP and may have a role in muscle signal transduction

# Metabolic_Enzyme_21_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_21_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_21_Signals:
None

# Metabolic_Enzyme_21_Transmembrane_Regions:
None

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_21_GenBank_ID_Protein:
5566609

# Metabolic_Enzyme_21_SwissProt_ID:
PDE7A_HUMAN (Q13946)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
PDE7A

# Metabolic_Enzyme_21_Geneatlas_id:
PDE7A

# Metabolic_Enzyme_21_hgnc_id:
HGNC:8791

# Metabolic_Enzyme_21_PDB_ID:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Note=PDE7A1 (57 kDa) is located mostly to soluble cellular fractions. PDE7A2 (50 kDa) is located to particulate cellular fractions

# Metabolic_Enzyme_21_Gene_Sequence:
>1449 bp
ATGGAAGTGTGTTACCAGCTGCCGGTACTGCCCCTGGACAGGCCGGTCCCCCAGCACGTC
CTCAGCCGCCGAGGAGCCATCAGCTTCAGCTCCAGCTCCGCTCTCTTCGGCTGCCCCAAT
CCCCGGCAGCTCTCTCAGAGGCGTGGAGCTATTTCCTATGACAGTTCTGATCAGACTGCA
TTATACATTCGTATGCTAGGAGATGTACGTGTAAGGAGCCGAGCAGGATTTGAATCAGAA
AGAAGAGGTTCTCACCCATATATTGATTTTCGTATTTTCCACTCTCAATCTGAAATTGAA
GTGTCTGTCTCTGCAAGGAATATCAGAAGGCTACTAAGTTTCCAGCGATATCTTAGATCT
TCACGCTTTTTTCGTGGTACTGCGGTTTCAAATTCCCTAAACATTTTAGATGATGATTAT
AATGGACAAGCCAAGTGTATGCTGGAAAAAGTTGGAAATTGGAATTTTGATATCTTTCTA
TTTGATAGACTAACAAATGGAAATAGTCTAGTAAGCTTAACCTTTCATTTATTTAGTCTT
CATGGATTAATTGAGTACTTCCATTTAGATATGATGAAACTTCGTAGATTTTTAGTTATG
ATTCAAGAAGATTACCACAGTCAAAATCCTTACCATAACGCAGTCCACGCTGCGGATGTT
ACTCAGGCCATGCACTGTTACTTAAAGGAACCTAAGCTTGCCAATTCTGTAACTCCTTGG
GATATCTTGCTGAGCTTAATTGCAGCTGCCACTCATGATCTGGATCATCCAGGTGTTAAT
CAACCTTTCCTTATTAAAACTAACCATTACTTGGCAACTTTATACAAGAATACCTCAGTA
CTGGAAAATCACCACTGGAGATCTGCAGTGGGCTTATTGAGAGAATCAGGCTTATTCTCA
CATCTGCCATTAGAAAGCAGGCAACAAATGGAGACACAGATAGGTGCTCTGATACTAGCC
ACAGACATCAGTCGCCAGAATGAGTATCTGTCTTTGTTTAGGTCCCATTTGGATAGAGGT
GATTTATGCCTAGAAGACACCAGACACAGACATTTGGTTTTACAGATGGCTTTGAAATGT
GCTGATATTTGTAACCCATGTCGGACGTGGGAATTAAGCAAGCAGTGGAGTGAAAAAGTA
ACGGAGGAATTCTTCCATCAAGGAGATATAGAAAAAAAATATCATTTGGGTGTGAGTCCA
CTTTGCGATCGTCACACTGAATCTATTGCCAACATCCAGATTGGTTTTATGACTTACCTA
GTGGAGCCTTTATTTACAGAATGGGCCAGGTTTTCCAATACAAGGCTATCCCAGACAATG
CTTGGACACGTGGGGCTGAATAAAGCCAGCTGGAAGGGACTGCAGAGAGAACAGTCGAGC
AGTGAGGACACTGATGCTGCATTTGAGTTGAACTCACAGTTATTACCTCAGGAAAATCGG
TTATCATAA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
L12052

# Metabolic_Enzyme_21_Chromosome_Location:
Not Available

# Metabolic_Enzyme_21_Locus:
Not Available

# Metabolic_Enzyme_21_SNPs:
Not Available

# Metabolic_Enzyme_21_General_References:
8389765; 9195912

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
5876

# Metabolic_Enzyme_22_Name:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

# Metabolic_Enzyme_22_Synonyms:
Not Available

# Metabolic_Enzyme_22_Gene_Name:
PDE10A

# Metabolic_Enzyme_22_Protein_Sequence:
>cAMP and cAMPinhibited cGMP 3',5'cyclic phosphodiesterase 10
AMRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESA
PKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGE
CNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGL
ESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQV
CRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKEL
YSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLY
TGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYH
RIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGI
FVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFT
DLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHN
IFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLM
MTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGF
YNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED


# Metabolic_Enzyme_22_Number_of_Residues:
779

# Metabolic_Enzyme_22_Molecular_Weight:
88413

# Metabolic_Enzyme_22_Theoretical_pI:
6.57

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Not Available

# Metabolic_Enzyme_22_Specific_Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This enzyme can hydrolyze both cAMP and cGMP, having a higher affinity for cAMP

# Metabolic_Enzyme_22_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_22_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF01590:GAF;
PF00233:PDEase_I

# Metabolic_Enzyme_22_Signals:
None

# Metabolic_Enzyme_22_Transmembrane_Regions:
None

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_22_GenBank_ID_Protein:
4958858

# Metabolic_Enzyme_22_SwissProt_ID:
PDE10_HUMAN (Q9Y233)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
PDE10A

# Metabolic_Enzyme_22_Geneatlas_id:
PDE10A

# Metabolic_Enzyme_22_hgnc_id:
HGNC:8772

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Note=Located mostly to soluble cellular fractions

# Metabolic_Enzyme_22_Gene_Sequence:
>2340 bp
ATGAGGATAGAAGAGAGGAAATCCCAACATTTAACAGGTTTGACAGATGAAAAAGTGAAG
GCATATCTTTCTCTTCACCCCCAGGTATTAGATGAATTTGTATCTGAAAGTGTTAGTGCA
GAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGATGAATCAGCTCCT
AAGGAAGTCAGCAGGTACCAAGATACGAATATGCAGGGAGTTGTATATGAACTAAACAGC
TATATAGAACAACGGTTGGACACAGGAGGAGACAACCAGCTACTCCTCTATGAACTGAGC
AGCATCATTAAAATAGCCACAAAAGCCGATGGATTTGCACTGTATTTCCTTGGAGAGTGC
AATAATAGCCTGTGTATATTCACGCCACCTGGGATAAAGGAAGGAAAACCCCGCCTCATC
CCTGCTGGGCCCATCACTCAGGGCACCACCGTCTCTGCTTATGTGGCCAAGTCCAGGAAA
ACACTGCTAGTAGAAGACATCCTTGGAGATGAACGATTTCCAAGAGGTACTGGACTGGAA
TCAGGGACTCGTATCCAGTCTGTTCTTTGCTTACCAATTGTCACTGCAATTGGTGACTTG
ATTGGTATTCTCGAGCTGTATCGGCACTGGGGCAAAGAAGCCTTCTGTCTTAGTCACCAG
GAGGTTGCAACAGCAAATCTTGCCTGGGCTTCAGTAGCAATACATCAGGTGCAGGTATGC
AGAGGCCTTGCCAAACAGACAGAATTGAATGACTTCCTACTCGACGTATCAAAAACATAT
TTTGATAACATAGTTGCAATAGATTCTCTACTTGAACACATAATGATATATGCAAAAAAC
CTGGTGAATGCCGATCGTTGTGCGCTTTTCCAGGTGGACCATAAGAACAAGGAGTTATAT
TCAGACCTTTTTGATATTGGAGAGGAAAAGGAAGGAAAACCTGTCTTCAAGAAGACCAAA
GAGATAAGATTTTCAATTGAGAAAGGAATTGCTGGCCAAGTAGCAAGAACAGGGGAAGTC
CTGAACATTCCAGATGCCTATGCAGACCCACGCTTTAACAGAGAAGTAGACTTGTACACA
GGCTACACCACGCGGAACATCCTGTGCATGCCCATCGTCAGCCGAGGCAGCGTGATAGGT
GTGGTGCAGATGGTCAACAAAATCAGTGGCAGTGCCTTCTCTAAAACAGATGAAAACAAC
TTCAAAATGTTTGCCGTCTTTTGTGCTTTAGCCTTACACTGTGCTAATATGTATCATAGA
ATTCGCCACTCAGAGTGCATTTACCGGGTAACGATGGAAAAGCTGTCCTACCATAGCATT
TGTACTTCAGAAGAGTGGCAAGGTCTCATGCAATTCACCCTTCCCGTGCGTCTCTGCAAA
GAAATTGAATTATTCCACTTTGACATTGGTCCTTTTGAAAACATGTGGCCTGGAATTTTT
GTCTACATGGTTCATCGGTCCTGTGGGACATCCTGCTTTGAGCTTGAAAAGTTGTGTCGT
TTTATTATGTCTGTGAAGAAGAACTATCGGCGGGTTCCTTATCACAACTGGAAGCATGCG
GTCACTGTAGCACACTGCATGTATGCCATACTTCAGAACAATCACACGCTTTTCACAGAC
CTTGAGCGCAAAGGACTGCTGATTGCGTGTCTGTGTCATGACCTGGACCACAGGGGCTTC
AGTAACAGCTACCTGCAGAAGTTCGACCACCCTCTGGCCGCTCTCTACTCCACTTCCACC
ATGGAGCAGCACCACTTCTCCCAGACTGTGTCCATCCTTCAGTTGGAAGGGCACAATATC
TTCTCCACTCTGAGCTCCAGTGAATATGAGCAGGTGCTTGAGATCATCCGCAAAGCCATC
ATTGCCACAGACCTTGCTTTATACTTTGGAAACAGGAAGCAGTTGGAAGAGATGTACCAG
ACCGGATCACTAAACCTTAATAATCAATCACATAGAGACCGTGTAATTGGTTTGATGATG
ACTGCCTGTGACCTTTGTTCTGTGACAAAACTGTGGCCCGTTACAAAATTGACGGCAAAT
GATATATATGCAGAATTCTGGGCTGAGGGTGATGAAATGAAGAAATTGGGAATACAGCCT
ATTCCTATGATGGACAGAGACAAGAAGGATGAAGTCCCCCAAGGCCAGCTTGGGTTCTAC
AATGCCGTGGCCATTCCCTGCTATACAACCCTTACCCAGATCCTCCCTCCCACGGAGCCT
CTTCTGAAAGCATGCAGGGATAATCTCAGTCAGTGGGAGAAGGTGATTCGAGGGGAGGAG
ACTGCAACCTGGATTTCATCCCCATCCGTGGCTCAGAAGGCAGCTGCATCTGAAGATTGA


# Metabolic_Enzyme_22_GenBank_ID_Gene:
AB020593

# Metabolic_Enzyme_22_Chromosome_Location:
Not Available

# Metabolic_Enzyme_22_Locus:
Not Available

# Metabolic_Enzyme_22_SNPs:
Not Available

# Metabolic_Enzyme_22_General_References:
10373451; 10393245; 14574404

# Metabolic_Enzyme_22_References:
Not Available

# Metabolic_Enzyme_23_ID:
5847

# Metabolic_Enzyme_23_Name:
High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

# Metabolic_Enzyme_23_Synonyms:
Not Available

# Metabolic_Enzyme_23_Gene_Name:
PDE8A

# Metabolic_Enzyme_23_Protein_Sequence:
>Highaffinity cAMPspecific and IBMXinsensitive 3',5'cyclic phosphodiesterase 8
AMGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGS
GKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLAC
FLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAG
FTRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQY
ANPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDN
IQQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGS
LDVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVL
EILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPI
SLDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLR
SWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVD
HPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQ
GIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKR
MLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQI
SFIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE

# Metabolic_Enzyme_23_Number_of_Residues:
829

# Metabolic_Enzyme_23_Molecular_Weight:
93305

# Metabolic_Enzyme_23_Theoretical_pI:
6.03

# Metabolic_Enzyme_23_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  two-component response regulator activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein histidine kinase activity
Function:  two-component sensor molecule activity
Function:  signal transducer activity
Function:  catalytic activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
Process:  two-component signal transduction system (phosphorelay)
Process:  two-component signal transduction system (phosphorelay)
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_23_General_Function:
Signal transduction mechanisms 

# Metabolic_Enzyme_23_Specific_Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase, which has a high affinity for cAMP, may be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development

# Metabolic_Enzyme_23_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_23_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF00989:PAS;
PF08629:PDE8;
PF00233:PDEase_I;
PF00072:Response_reg

# Metabolic_Enzyme_23_Signals:
None

# Metabolic_Enzyme_23_Transmembrane_Regions:
None

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_23_GenBank_ID_Protein:
16417190

# Metabolic_Enzyme_23_SwissProt_ID:
PDE8A_HUMAN (O60658)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
PDE8A

# Metabolic_Enzyme_23_Geneatlas_id:
PDE8A

# Metabolic_Enzyme_23_hgnc_id:
HGNC:8793

# Metabolic_Enzyme_23_PDB_ID:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_23_Gene_Sequence:
>2490 bp
ATGGGCTGTGCCCCGAGCATCCACATTTCCGAGCGCCTGGTGGCCGAGGACGCGCCTAGC
CCCGCGGCACCGCCGCTGTCGTCCGGCGGGCCGCGCCTCCCGCAGGGCCAGAAGACGGCC
GCCTTGCCCCGGACCCGCGGCGCCGGCCTCTTGGAGTCGGAGCTTCGCGACGGCAGCGGC
AAGAAGGTAGCAGTAGCTGATGTGCAGTTTGGCCCCATGAGATTTCATCAAGATCAACTT
CAGGTACTTTTAGTGTTTACCAAAGAAGATAACCAATGTAATGGATTCTGCAGGGCATGT
GAAAAAGCAGGGTTTAAGTGTACAGTTACCAAGGAGGCTCAGGCTGTCCTTGCCTGTTTC
CTGGACAAACATCATGACATTATCATCATAGACCACAGAAATCCTCGACAGCTGGATGCA
GAGGCACTGTGCAGGTCTATCAGATCATCAAAACTCTCAGAAAACACAGTTATTGTTGGT
GTAGTACGCAGGGTGGATAGAGAAGAGTTGTCCGTAATGCCTTTCATTTCTGCTGGATTT
ACAAGGAGGTATGTAGAAAACCCCAACATCATGGCCTGCTACAATGAACTGCTCCAGCTG
GAGTTTGGAGAGGTGCGATCACAACTGAAACTCAGGGCTTGTAACTCAGTATTCACTGCA
TTAGAAAACAGTGAAGATGCAATTGAAATTACAAGCGAAGACCGTTTTATACAGTATGCA
AATCCTGCATTTGAAACAACAATGGGCTATCAGTCAGGTGAATTAATAGGGAAGGAGTTA
GGAGAAGTGCCTATAAATGAAAAAAAGGCTGACTTGCTCGATACTATAAATTCATGCATC
AGGATAGGCAAGGAGTGGCAAGGAATTTACTATGCAAAAAAGAAAAACGGAGATAATATA
CAACAAAATGTGAAGATAATACCTGTCATTGGACAGGGAGGAAAAATTAGACACTATGTG
TCCATTATCAGAGTGTGCAATGGCAACAATAAGGCTGAGAAAATATCCGAATGTGTTCAG
TCTGACACTCATACAGATAATCAGACAGGCAAACATAAAGACAGGAGAAAAGGCTCACTA
GACGTCAAAGCTGTTGCCTCCCGTGCAACTGAAGTTTCCAGCCAGAGACGACACTCTTCC
ATGGCCCGGATACATTCCATGACAATTGAGGCGCCCATCACCAAGGTAATCAATATTATC
AATGCTGCCCAGGAAAGTAGTCCCATGCCTGTGACAGAAGCCCTAGACCGTGTGCTGGAA
ATTCTAAGAACCACTGAGTTATATTCACCACAGTTTGGTGCTAAAGATGATGATCCCCAT
GCCAATGACCTTGTTGGGGGCTTAATGTCTGATGGTTTGCGAAGACTATCAGGGAATGAA
TATGTTCTTTCAACAAAAAACACTCAAATGGTTTCAAGCAATATAATCACTCCCATCTCC
CTTGATGATGTCCCACCACGGATAGCTCGGGCCATGGAAAATGAGGAATACTGGGACTTT
GATATTTTTGAACTGGAGGCTGCCACCCACAATAGGCCTTTGATTTATCTTGGTCTCAAA
ATGTTTGCTCGCTTTGGAATCTGTGAATTCTTACACTGCTCCGAGTCAACGCTAAGATCA
TGGTTACAAATTATCGAAGCCAATTATCATTCCTCCAATCCCTACCACAATTCTACACAT
TCTGCTGATGTGCTTCATGCCACTGCCTATTTTCTCTCCAAGGAGAGGATAAAGGAAACT
TTAGATCCAATTGATGAGGTCGCTGCACTCATCGCAGCCACCATTCATGATGTGGATCAC
CCTGGGAGAACCAACTCCTTCCTGTGTAATGCTGGAAGTGAGCTGGCCATTTTGTACAAT
GACACTGCTGTGCTGGAGAGCCACCATGCGGCCTTGGCCTTCCAGCTGACCACTGGAGAT
GATAAATGCAATATATTTAAAAACATGGAGAGGAATGATTATCGGACACTGCGCCAGGGG
ATTATCGACATGGTCTTAGCCACAGAAATGACAAAGCACTTTGAGCATGTCAACAAATTT
GTCAACAGCATCAACAAACCCTTGGCAACACTAGAAGAAAATGGGGAAACTGATAAAAAC
CAGGAAGTGATAAACACTATGCTTAGGACTCCAGAGAACCGGACCCTAATCAAACGAATG
CTGATTAAATGTGCTGATGTGTCCAATCCCTGCCGACCCCTGCAGTACTGCATCGAGTGG
GCTGCACGCATTTCGGAAGAATATTTTTCTCAGACTGATGAAGAGAAGCAGCAGGGCTTA
CCTGTGGTGATGCCAGTGTTTGACAGAAATACCTGCAGCATCCCCAAATCCCAAATCTCT
TTCATTGATTACTTCATCACAGACATGTTTGATGCTTGGGATGCCTTTGTAGACCTGCCT
GATTTAATGCAGCATCTTGACAACAACTTTAAATACTGGAAAGGACTGGACGAAATGAAG
CTGCGGAACCTCCGACCACCTCCTGAATAG

# Metabolic_Enzyme_23_GenBank_ID_Gene:
AF388183

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_23_Locus:
15q25.3

# Metabolic_Enzyme_23_SNPs:
rs16974908; rs289392; rs2304422; rs289412; rs289389; rs734495; rs1973516; rs1014543; rs289374; rs289417; rs2342974; rs1868921; rs930716; rs289400; rs289390; rs12904386; rs289383; rs289393; rs12904890; rs12437935; rs289414; rs289411; rs6496586; rs3816106; rs289405; rs7402176; rs2290273; rs289387; rs7402932; rs289410; rs8026543; rs379799; rs12903975; rs4843019; rs289386; rs3816104; rs11073916; rs3816103; rs289418; rs11856330; rs2304416; rs4842864; rs7174722; rs2304417; rs11073917; rs8032301; rs289399; rs7182533; rs971804; rs185972; rs418676; rs11073939; rs8038149; rs2304420; rs7402770; rs9920027; rs2304419; rs409211; rs7403474; rs2122858; rs289416; rs7163965; rs208966; rs7175477; rs2304418; rs744422; rs10852130; rs12440719; rs11631548; rs12912134; rs190840; rs11632658; rs12232314; rs12102045; rs10520586; rs289419; rs11854452; rs2923731; rs1011436; rs2015233; rs2304421; rs289381; rs289388; rs12904238; rs7182328; rs289401; rs12438909; rs17540307; rs2938354; rs3816105; rs289380; rs289406; rs12902942; rs17611396; rs4842865; rs16974823; rs17541051; rs1011437; rs289402; rs17610201; rs289396; rs289375; rs11631171; rs2304415; rs289403; rs1969101; rs17611171; rs17612860; rs11856097; rs8032954; rs12441196; rs7174762; rs11632899; rs1023844; rs16974676; rs16974785; rs12592539; rs16974197; rs12910668; rs2174218; rs12909971; rs7402179; rs289404; rs12913859; rs4843014; rs289391; rs380185; rs289373; rs289413; rs289409; rs289379; rs4842863; rs16974804; rs12910060; rs4843015; rs11634975; rs11858363; rs12905036; rs12904615; rs16974868; rs12903145; rs289378; rs289407; rs16974819; rs7182132; rs4980356; rs17841204; rs16974764; rs16974757; rs8039136; rs17611290; rs7170598; rs12909111; rs12900736; rs12438541; rs377369; rs16974726; rs395573; rs11634877; rs12900012; rs9302348; rs16974846; rs13380056; rs7359256; rs12904766; rs11637237; rs4980340; rs289376; rs289382; rs17610265; rs4842866; rs16974870; rs11632175; rs11856381; rs12899693; rs7403468; rs16974769; rs12904410; rs12906544; rs289420; rs35000527; rs12908535; rs12908400; rs11629962; rs17611075; rs167036; rs1532776; rs8029977; rs12912860; rs12911330; rs8039116; rs10083650; rs2599365; rs4843018; rs16974820; rs8028550; rs12908252; rs2599364; rs188296; rs8040352; rs7402299; rs11852878; rs8025202; rs12916129; rs16974844; rs16974793; rs16974867; rs8029936; rs289415; rs7178852; rs9796658; rs11629963; rs289397; rs8035204; rs16974732; rs7178157; rs17540501; rs16974775; rs12440263; rs12324252; rs16974842; rs16974673; rs12909130; rs439307; rs289398; rs8023667; rs8041380; rs11073905; rs11637512; rs4296226; rs7403597; rs11629967; rs3850985; rs11854185; rs16974759; rs439313; rs16974194; rs12591070; rs10852131; rs11073915; rs12439284; rs16974777; rs11630697; rs7183199; rs16974791; rs16974827; rs11631184; rs11073955; rs6496733; rs994989; rs11073962; rs8041624; rs7167692; rs11073952; rs4843020; rs4842868; rs16974899; rs13379959; rs12592211; rs1606119; rs7171410; rs907260; rs3743157; rs6496728; rs3862411; rs17541572; rs10520585; rs11852268; rs11073951; rs12899508; rs7177110; rs16974896; rs16974907; rs12324715; rs10152707; rs16974898; rs12594377; rs16974913; rs4842867; rs12324638; rs12904058; rs11633076; rs12914674; rs12324243; rs12148170; rs16974889; rs11638610; rs2063441; rs11540803; rs17855018; rs35666574; rs35134026; rs28517708; rs34477344; rs289377; rs34139398; rs3835084; rs12905238; rs36160047; rs11633746; rs35038078; rs35476219; rs34096140; rs28583919; rs36146722; rs16974849; rs28599738; rs11447909; rs34187163; rs35529308; rs10683452; rs34026921; rs10686479; rs28393234; rs12912097; rs3042715; rs35843593; rs35816571; rs7496602; rs35835700; rs34212320; rs34978449; rs10596049; rs12593868; rs12903901; rs5814181; rs35668291; rs4980341; rs35902872; rs34345801; rs35287208; rs12443441; rs36226498; rs182326; rs28432948; rs4038084; rs35024665; rs28626509; rs28674753; rs4038603; rs10714340; rs35613655; rs12899359; rs16974740; rs12899190; rs9920206; rs12904958; rs34715649; rs12916821; rs28703945; rs34741081; rs12908865; rs16974874; rs7163704; rs2654915; rs3077007; rs16974881; rs34743976; rs13379950; rs35119272; rs28481453; rs10551825; rs28871662; rs35955528; rs16974781; rs35060961; rs35991556; rs35159041; rs34039117; rs28522595; rs35051517; rs34571125; rs12595013; rs34431228; rs28422178; rs35472864; rs2599366; rs35885781; rs34623053; rs13379744; rs289394; rs35224089; rs10583862; rs12910192; rs11279216; rs9920260; rs35985534; rs28460774; rs34072250; rs12910966; rs11300943; rs2134701; rs12915883; rs28821898; rs16974754; rs28718705; rs8040568; rs35204319; rs35155549; rs16974851; rs3947198; rs34868660; rs12911951; rs35362357; rs11408402; rs12905230; rs8031544; rs35835007; rs35886421; rs12593499; rs289395; rs16974834; rs5814184; rs35127646; rs34005057; rs7181707; rs35924887; rs11302685; rs12913418; rs34900320; rs11315378; rs12911275; rs11335223; rs34941017; rs36184157; rs28624247; rs12324120; rs34578731; rs35013304; rs35704021; rs34919315; rs35100589; rs28451934; rs12910937; rs28515053; rs35850143; rs35495694; rs35661908; rs34450665; rs28887294; rs35165347; rs3029849; rs3076299; rs12912264; rs28660426; rs36210492; rs1466166; rs28408242; rs4843016; rs3042743; rs188295; rs35845738; rs35782842; rs16974722; rs28401313; rs35332444; rs8033951; rs28635537; rs289408; rs4461049; rs34347191; rs3752716; rs7167955; rs34224590; rs28380121; rs2134700; rs28836780; rs34928221; rs11444714; rs13379486; rs289385; rs28567794; rs12913075; rs34585903; rs35932936; rs13380094; rs28435132; rs5814182; rs35818984; rs28438405; rs3042699; rs34054841; rs7496012; rs3042742; rs4843017; rs34703175; rs34493704; rs185973; rs5814185; rs11300141; rs28406814; rs11439217; rs16974713; rs33996207; rs34731527; rs34127115; rs28369034; rs28765192; rs34366010; rs12909357; rs28669942; rs35249102; rs35710429; rs12913985; rs10656480; rs28614128; rs3947199; rs28767827; rs34363361; rs3076297; rs5814183; rs16974847; rs289384; rs35525107; rs11286200; rs28584329; rs28878517; rs35570249; rs34684329; rs34469124; rs35150470; rs35148427; rs34262848; rs2060785; rs35187382; rs11362736; rs905600; rs28523473; rs12906040; rs11308498; rs12904056; rs34105012; rs2015030; rs4843013; rs11438322; rs35349728; rs34790691; rs2005228; rs28715864; rs8032061; rs28483160; rs35094470; rs6496597; rs34376876; rs35007697; rs34486009; rs16974680; rs28599761; rs35166229; rs10525874; rs34787669; rs34946321; rs12914463; rs34343213; rs35264353; rs3214641; rs35094035; rs35490949; rs2060784; rs35548176; rs4980357; rs12917019; rs28540038; rs35668265; rs28679569; rs3743158; rs10152517; rs6145662; rs35865189; rs34076898; rs28762802; rs35054546; rs16974903; rs1272789; rs16974914; rs34339351; rs35533990; rs35045545; rs28463717; rs1260127; rs28445014; rs12324052; rs34889576; rs35457936; rs34655030; rs16974894; rs8032913; rs34002838; rs35114584; rs36097427; rs34969758; rs1109065; rs1109066; rs11635139; rs12439802; rs12899275; rs12900078; rs35966827; rs7175160; rs7177863; rs7178415; rs8035516; rs8037886; rs896364

# Metabolic_Enzyme_23_General_References:
11738832; 9618252

# Metabolic_Enzyme_23_References:
Not Available

# Metabolic_Enzyme_24_ID:
5843

# Metabolic_Enzyme_24_Name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

# Metabolic_Enzyme_24_Synonyms:
Cam-PDE 1A; 61 kDa Cam-PDE; hCam-1

# Metabolic_Enzyme_24_Gene_Name:
PDE1A

# Metabolic_Enzyme_24_Protein_Sequence:
>Calcium/calmodulindependent 3',5'cyclic nucleotide phosphodiesterase 1
AMGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYA
ASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFR
SIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFM
IYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTG
IMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRL
MQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMS
LILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIG
FIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKG
SMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ

# Metabolic_Enzyme_24_Number_of_Residues:
535

# Metabolic_Enzyme_24_Molecular_Weight:
61253

# Metabolic_Enzyme_24_Theoretical_pI:
6.02

# Metabolic_Enzyme_24_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_24_General_Function:
Not Available

# Metabolic_Enzyme_24_Specific_Function:
Has a higher affinity for cGMP than for cAMP

# Metabolic_Enzyme_24_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_24_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_24_Pfam_Domain_Function:
PF00233:PDEase_I;
PF08499:PDEase_I_N

# Metabolic_Enzyme_24_Signals:
None

# Metabolic_Enzyme_24_Transmembrane_Regions:
None

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_24_GenBank_ID_Protein:
1151109

# Metabolic_Enzyme_24_SwissProt_ID:
PDE1A_HUMAN (P54750)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
PDE1A

# Metabolic_Enzyme_24_Geneatlas_id:
PDE1A

# Metabolic_Enzyme_24_hgnc_id:
HGNC:8774

# Metabolic_Enzyme_24_PDB_ID:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_24_Gene_Sequence:
>1608 bp
ATGGGGTCTAGTGCCACAGAGATTGAAGAATTGGAAAACACCACTTTTAAGTATCTTACA
GGAGAACAGACTGAAAAAATGTGGCAGCGCCTGAAAGGAATACTAAGATGCTTGGTGAAG
CAGCTGGAAAGAGGTGATGTTAACGTCGTCGACTTAAAGAAGAATATTGAATATGCGGCA
TCTGTGCTGGAAGCAGTTTATATCGATGAAACAAGAAGACTTCTGGATACTGAAGATGAG
CTCAGTGACATTCAGACTGACTCAGTCCCATCTGAAGTCCGGGACTGGTTGGCTTCTACC
TTTACACGGAAAATGGGGATGACAAAAAAGAAACCTGAGGAAAAACCAAAATTTCGGAGC
ATTGTGCATGCTGTTCAAGCTGGAATTTTTGTGGAAAGAATGTACCGAAAAACATATCAT
ATGGTTGGTTTGGCATATCCAGCAGCTGTCATCGTAACATTAAAGGATGTTGATAAATGG
TCTTTCGATGTATTTGCCCTAAATGAAGCAAGTGGAGAGCATAGTCTGAAGTTTATGATT
TATGAACTGTTTACCAGATATGATCTTATCAACCGTTTCAAGATTCCTGTTTCTTGCCTA
ATCACCTTTGCAGAAGCTTTAGAAGTTGGTTACAGCAAGTACAAAAATCCATATCACAAT
TTGATTCATGCAGCTGATGTCACTCAAACTGTGCATTACATAATGCTTCATACAGGTATC
ATGCACTGGCTCACTGAACTGGAAATTTTAGCAATGGTCTTTGCTGCTGCCATTCATGAT
TATGAGCATACAGGGACAACAAACAACTTTCACATTCAGACAAGGTCAGATGTTGCCATT
TTGTATAATGATCGCTCTGTCCTTGAGAATCACCACGTGAGTGCAGCTTATCGACTTATG
CAAGAAGAAGAAATGAATATCTTGATAAATTTATCCAAAGATGACTGGAGGGATCTTCGG
AACCTAGTGATTGAAATGGTTTTATCTACAGACATGTCAGGTCACTTCCAGCAAATTAAA
AATATAAGAAACAGTTTGCAGCAGCCTGAAGGGATTGACAGAGCCAAAACCATGTCCCTG
ATTCTCCACGCAGCAGACATCAGCCACCCAGCCAAATCCTGGAAGCTGCATTATCGGTGG
ACCATGGCCCTAATGGAGGAGTTTTTCCTGCAGGGAGATAAAGAAGCTGAATTAGGGCTT
CCATTTTCCCCACTTTGTGATCGGAAGTCAACCATGGTGGCCCAGTCACAAATAGGTTTC
ATCGATTTCATAGTAGAGCCAACATTTTCTCTTCTGACAGACTCAACAGAGAAAATTGTT
ATTCCTCTTATAGAGGAAGCCTCAAAAGCCGAAACTTCTTCCTATGTGGCAAGCAGCTCA
ACCACCATTGTGGGGTTACACATTGCTGATGCACTAAGACGATCAAATACAAAAGGCTCC
ATGAGTGATGGGTCCTATTCCCCAGACTACTCCCTTGCAGCAGTGGACCTGAAGAGTTTC
AAGAACAACCTGGTGGACATCATTCAGCAGAACAAAGAGAGGTGGAAAGAGTTAGCTGCA
CAAGAAGCAAGAACCAGTTCACAGAAGTGTGAGTTTATTCATCAGTAA

# Metabolic_Enzyme_24_GenBank_ID_Gene:
U40370

# Metabolic_Enzyme_24_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_24_Locus:
2q32.1

# Metabolic_Enzyme_24_SNPs:
rs6749969; rs6734868; rs1432531; rs1999; rs28364747; rs2368253; rs1196064; rs1430163; rs833149; rs2623431; rs964758; rs833182; rs1430143; rs2623423; rs1432534; rs964757; rs833166; rs833142; rs1864852; rs1430142; rs718448; rs1196065; rs1383898; rs1438072; rs1432520; rs833175; rs2623421; rs1430145; rs2368252; rs1367201; rs1347079; rs2568664; rs1367202; rs1196062; rs1988750; rs2368301; rs1864850; rs1432523; rs1991765; rs2128043; rs1196060; rs833152; rs1370666; rs1370669; rs1196058; rs1430162; rs1835881; rs1864849; rs1432517; rs2568672; rs2623436; rs1196059; rs2860078; rs2887202; rs1432521; rs1864855; rs1946815; rs2623438; rs2568675; rs833178; rs2568667; rs1432522; rs833123; rs833115; rs1564542; rs2170403; rs833122; rs833179; rs1560371; rs10931010; rs12474760; rs2128046; rs10931015; rs1992183; rs2887217; rs7598327; rs994155; rs1864847; rs833134; rs11690832; rs833125; rs4629124; rs10930998; rs12468232; rs1864853; rs10497604; rs2368296; rs1432533; rs3769801; rs833148; rs10931009; rs1432515; rs12466618; rs11683479; rs2118484; rs1438065; rs3769806; rs1196074; rs12624259; rs1560370; rs2568663; rs4666828; rs1595450; rs12465662; rs1946602; rs833124; rs2368294; rs12328342; rs4503956; rs10931016; rs7583421; rs6741055; rs2887218; rs10930999; rs6433976; rs4644985; rs10181526; rs2577659; rs3769788; rs11689230; rs1125184; rs7597711; rs1991596; rs300885; rs6740124; rs6706326; rs7589989; rs6759303; rs2128042; rs6760317; rs833118; rs7581210; rs10931002; rs1344772; rs833145; rs6719036; rs13034133; rs2368255; rs12693302; rs12474820; rs11891890; rs10193166; rs1430144; rs4643498; rs10930997; rs7593755; rs12468743; rs12693301; rs10931013; rs11884886; rs13036034; rs1430160; rs6759413; rs9789764; rs6433974; rs1481630; rs6740244; rs7597380; rs1370668; rs4666585; rs833126; rs2164861; rs1346775; rs6721984; rs833130; rs2887200; rs11679657; rs6759450; rs3769809; rs991927; rs10931022; rs10178586; rs833113; rs1196067; rs10930993; rs1594615; rs10197295; rs4666836; rs12996836; rs2623437; rs2368298; rs10184548; rs1430157; rs10931008; rs2368256; rs6718589; rs10206828; rs753289; rs1991766; rs1430159; rs12612546; rs6433959; rs833119; rs934260; rs10206325; rs1438069; rs1370667; rs4666835; rs3754929; rs11902391; rs1594304; rs1438071; rs724851; rs1864445; rs4666819; rs6758334; rs9653242; rs2577661; rs11899043; rs833141; rs2623409; rs11676337; rs1594617; rs10930991; rs6736414; rs7558737; rs3769791; rs1196066; rs7569537; rs4666815; rs1021090; rs833168; rs7585752; rs1438070; rs833140; rs2082135; rs9784041; rs4666582; rs1370665; rs2195878; rs12473534; rs12475647; rs10169102; rs11883669; rs10931012; rs12622714; rs2368295; rs12477696; rs13400536; rs12474371; rs10204284; rs4666817; rs833156; rs6433973; rs12477494; rs11892984; rs6734447; rs13406145; rs12693300; rs934261; rs1594305; rs7606428; rs7557419; rs1368216; rs17343416; rs2568681; rs1367203; rs11674335; rs11692649; rs16823044; rs13400054; rs4572561; rs7592850; rs934264; rs833135; rs6715692; rs1367204; rs1210652; rs6750552; rs11684934; rs1560372; rs7571503; rs11690257; rs2128045; rs16823102; rs833176; rs11686025; rs6433958; rs833138; rs3769803; rs4496292; rs12693299; rs17356152; rs11887327; rs10497605; rs12467240; rs2623432; rs12693308; rs12475048; rs12468346; rs13410344; rs13392487; rs7562805; rs12616214; rs6747821; rs12621579; rs7599577; rs4666827; rs4335909; rs11682598; rs11898512; rs11894978; rs17265405; rs1432518; rs2368278; rs1560375; rs10197136; rs11691411; rs11886669; rs2082136; rs1564543; rs11887703; rs17343395; rs6728410; rs1897104; rs1864851; rs4666587; rs10931020; rs16823124; rs833162; rs2368299; rs864417; rs2368300; rs17265322; rs833154; rs833146; rs12479259; rs12617420; rs6760364; rs6433964; rs11900878; rs16823319; rs833117; rs6728235; rs10186868; rs1196069; rs10803955; rs1432519; rs2368254; rs2623410; rs9288080; rs1594618; rs1967008; rs13417045; rs16823047; rs2368277; rs12469500; rs3769796; rs2623430; rs3769800; rs11684406; rs6757164; rs2170400; rs10174383; rs12989198; rs7574051; rs2170402; rs16823122; rs1021092; rs6724256; rs11892848; rs10931000; rs10497601; rs16822799; rs11884145; rs1471587; rs2368297; rs16823179; rs12693305; rs1583112; rs6726121; rs17356200; rs3769802; rs17356207; rs10497597; rs6740401; rs16823171; rs13432152; rs10497595; rs13417404; rs10171703; rs1842640; rs6433960; rs6433963; rs3769811; rs7585427; rs12467526; rs11895738; rs1347732; rs1196072; rs3769789; rs3769810; rs12617844; rs9288081; rs2368302; rs2568673; rs17366198; rs11675519; rs12994855; rs12477627; rs1549870; rs10207132; rs10497600; rs6740226; rs12693304; rs4666584; rs7595025; rs16823163; rs10497602; rs1430146; rs10930995; rs11678230; rs1595448; rs6740889; rs4666851; rs7567023; rs3820963; rs7563753; rs7578466; rs10931014; rs1196070; rs12693303; rs12466937; rs10169895; rs11681840; rs3769792; rs17356303; rs12470644; rs3940474; rs833174; rs1594614; rs11891405; rs11677155; rs13420620; rs833180; rs2276612; rs833128; rs11895090; rs2099185; rs10931017; rs11888602; rs833177; rs17356166; rs17265294; rs10209382; rs10497603; rs11690037; rs16823254; rs12693307; rs833170; rs7567423; rs7597921; rs1346773; rs16823201; rs1438068; rs1595449; rs1897472; rs2368280; rs4666846; rs1430141; rs4666578; rs12616751; rs10497599; rs17366503; rs4480955; rs7578703; rs10206152; rs10931011; rs9332425; rs3856410; rs833160; rs2195611; rs16823011; rs7422491; rs10497598; rs16823106; rs3769794; rs17264929; rs833158; rs833120; rs11677310; rs833181; rs10174618; rs7606875; rs12693306; rs1595445; rs2623435; rs6733603; rs6733935; rs6751445; rs11686989; rs1864854; rs17457136; rs2887199; rs11687469; rs11678901; rs10196288; rs6720739; rs4666845; rs2568674; rs2196695; rs11893572; rs7601804; rs4666583; rs10930992; rs7561341; rs10180233; rs1594306; rs11678804; rs13410259; rs7591292; rs833114; rs4666579; rs2368276; rs833159; rs1196073; rs2128047; rs16823207; rs17457303; rs6729400; rs833116; rs2448980; rs13385209; rs2577649; rs2623418; rs12990168; rs13399478; rs12470722; rs1898591; rs833155; rs2887207; rs4666844; rs2568677; rs7597403; rs2118485; rs7591416; rs6720942; rs2623422; rs2053270; rs1121403; rs12612357; rs13020976; rs16822749; rs2577658; rs12616179; rs4594404; rs6760589; rs16823184; rs16822776; rs10197132; rs6747822; rs11678948; rs7606009; rs16823203; rs12468333; rs1438073; rs2623417; rs16823235; rs9711046; rs1383899; rs16823222; rs2568661; rs12622605; rs2368279; rs6726324; rs6718641; rs2568684; rs16823233; rs16823317; rs17265027; rs16823287; rs6728985; rs6761081; rs10198076; rs4091077; rs16823182; rs1481629; rs16822886; rs833165; rs34053285; rs6709051; rs12616229; rs16823234; rs4666834; rs16823275; rs3820962; rs6730984; rs2623412; rs2568670; rs9753060; rs16823678; rs16822961; rs12475637; rs16822915; rs11690853; rs12987958; rs16823010; rs4666841; rs833147; rs2217614; rs2438288; rs1837167; rs4630732; rs1196068; rs4666850; rs1438075; rs2118487; rs833139; rs13030388; rs16823686; rs17265041; rs6751461; rs16823220; rs11687076; rs2448982; rs17265061; rs11685463; rs1432525; rs10165500; rs9753059; rs16823199; rs17343304; rs1430150; rs12988258; rs10182266; rs17343311; rs34103461; rs17356331; rs11677543; rs6744832; rs16823243; rs4555308; rs13388594; rs16822745; rs7578481; rs6433970; rs6714282; rs16823257; rs4383292; rs833127; rs17265166; rs13428559; rs11681620; rs1438074; rs17264796; rs1344773; rs300884; rs12470801; rs17457344; rs1196063; rs1560374; rs3769778; rs13400663; rs13397213; rs6729405; rs2448981; rs10188331; rs2568687; rs13388711; rs833144; rs833163; rs17356296; rs12470124; rs4666586; rs10200242; rs16822895; rs6717783; rs3769805; rs12465755; rs1583114; rs12478553; rs13388735; rs2577651; rs10181570; rs13383296; rs12472694; rs4583416; rs833173; rs17265189; rs16822899; rs12615015; rs16823227; rs17343318; rs724376; rs17356463; rs10209868; rs2568665; rs7589555; rs17595927; rs6754260; rs2568680; rs1430161; rs6725769; rs17265350; rs17410250; rs866732; rs1430147; rs10199957; rs10185985; rs3769790; rs1432516; rs2623426; rs4666820; rs6705950; rs4666824; rs4666829; rs11677136; rs2082134; rs1430148; rs2623420; rs17265203; rs6718531; rs12469046; rs711807; rs6741105; rs2099184; rs4666840; rs6720671; rs833151; rs16823249; rs7592388; rs10209197; rs4583421; rs2577663; rs13024682; rs13398665; rs7588289; rs2170401; rs2887215; rs11695445; rs10171911; rs12478132; rs11674733; rs4318355; rs4666823; rs4632308; rs12614214; rs2568666; rs16823156; rs10930996; rs17264887; rs10201929; rs17264880; rs1542584; rs2577652; rs2623427; rs10185590; rs1988751; rs7595111; rs6721940; rs11677709; rs1430158; rs11899588; rs7567112; rs833131; rs2568671; rs711806; rs11903131; rs13407156; rs833153; rs1595446; rs17356214; rs10189043; rs2568683; rs16823229; rs12473820; rs4018737; rs865001; rs17457323; rs13035314; rs12465757; rs833157; rs17595863; rs6758298; rs10803956; rs11683084; rs16823120; rs16822892; rs833167; rs16822918; rs2438290; rs16823168; rs6747766; rs4666580; rs7589514; rs4666830; rs16823151; rs1864848; rs10202082; rs3769797; rs10195640; rs2568676; rs11685510; rs4666838; rs4666822; rs4666826; rs16823150; rs17264894; rs16822889; rs10931018; rs833172; rs11887150; rs10497596; rs16823277; rs3769786; rs7561075; rs11676559; rs13394418; rs16823285; rs4018730; rs167284; rs833171; rs2623439; rs17457164; rs9798118; rs16823236; rs6734150; rs13403591; rs10207047; rs2577660; rs964756; rs16822768; rs711808; rs17265384; rs12621190; rs4666837; rs10198216; rs13406342; rs17366218; rs10200025; rs833150; rs16823158; rs1438067; rs9711070; rs4666825; rs6720583; rs2568660; rs10175845; rs1351492; rs2128044; rs10931021; rs865578; rs7560332; rs13003148; rs3769779; rs4666577; rs2303890; rs3754928; rs1921153; rs12105839; rs17649281; rs1057945; rs5836825; rs3210428; rs2276613; rs34657010; rs1484; rs34392771; rs1560373; rs35704530; rs13016087; rs2568662; rs28870438; rs1142499; rs7591196; rs3063101; rs10204911; rs13021857; rs35927091; rs10195097; rs10184869; rs1438066; rs35087060; rs34269574; rs5836832; rs34206320; rs34200314; rs7608624; rs34318365; rs36099854; rs11376015; rs35771061; rs3835906; rs13404757; rs13410703; rs13397815; rs34744930; rs13391931; rs10667573; rs35084880; rs35321986; rs34436167; rs35061201; rs34978102; rs16823159; rs35932804; rs34981789; rs35467151; rs34523452; rs35075463; rs36067516; rs34934382; rs13025145; rs28369479; rs33922098; rs16822795; rs11336735; rs13418736; rs11376014; rs9712068; rs35204121; rs34884579; rs35019955; rs10432427; rs35032256; rs833164; rs34538059; rs2118486; rs33987953; rs35764937; rs4544391; rs6728245; rs4505483; rs35247872; rs35851840; rs5836827; rs3769787; rs13411042; rs13402461; rs16822784; rs2577648; rs34602848; rs6707322; rs35760311; rs1196075; rs34257247; rs16822812; rs4666818; rs35372886; rs3835908; rs1142496; rs5004861; rs17264817; rs34418595; rs2217424; rs36079245; rs34716524; rs5836830; rs13403996; rs1346774; rs35239912; rs33944928; rs34241797; rs3835905; rs13405173; rs10546002; rs10182192; rs13020356; rs10679939; rs2163695; rs35081866; rs35642510; rs9752179; rs6736660; rs11329645; rs12623018; rs34497200; rs10661926; rs13012803; rs6720202; rs34799454; rs35092643; rs12995785; rs34735471; rs13015852; rs16823072; rs6712992; rs34157460; rs7581170; rs6759207; rs35485908; rs34120183; rs11351148; rs34225086; rs35394100; rs6740676; rs35825733; rs35806345; rs34219838; rs3209104; rs28569979; rs4666581; rs28701896; rs34165544; rs11677223; rs35777140; rs12991791; rs3835907; rs11333920; rs34505391; rs35030431; rs28420082; rs2195880; rs6729094; rs833132; rs35600244; rs10649015; rs6147058; rs36120860; rs13028649; rs13413938; rs36047430; rs35608334; rs3062171; rs35164921; rs34487617; rs12988815; rs1196061; rs35122269; rs13012388; rs35843666; rs7601239; rs34665608; rs4666833; rs34868101; rs13410842; rs35797263; rs5836834; rs13001576; rs6734332; rs35829416; rs34388968; rs11675803; rs11348029; rs300882; rs1816654; rs3209105; rs35327523; rs35226392; rs16822851; rs5836829; rs9798131; rs13416498; rs34670464; rs34307690; rs35470057; rs28807785; rs35161948; rs34156888; rs34185607; rs34636057; rs11394200; rs34019486; rs10632753; rs13393694; rs16822739; rs35085933; rs12470794; rs35219304; rs35928664; rs34461539; rs6433975; rs9678854; rs35176528; rs6748063; rs11349101; rs11442872; rs10173255; rs13017441; rs34780932; rs34850993; rs3940475; rs6761344; rs12104898; rs35169307; rs28439754; rs35840738; rs34929129; rs10529301; rs34483465; rs34669140; rs36010429; rs833133; rs2887208; rs36059127; rs866733; rs5836833; rs9712067; rs833136; rs13035123; rs34344623; rs3769795; rs35131293; rs16822753; rs35577192; rs2577654; rs36212772; rs12053027; rs833143; rs34167707; rs28820373; rs10595375; rs13033301; rs922732; rs2568682; rs35196240; rs4369824; rs4666852; rs34173972; rs10176807; rs34393660; rs13402892; rs34377459; rs10626467; rs11349102; rs34133532; rs34963796; rs34609810; rs11420985; rs34296220; rs11681511; rs34674764; rs28773524; rs34846500; rs10691371; rs28520932; rs35187563; rs16822777; rs34224743; rs300883; rs34172306; rs34236186; rs35764684; rs11379999; rs13025112; rs11375672; rs10590540; rs16823164; rs13399931; rs34299616; rs2577655; rs2577664; rs36121688; rs1835880; rs3062169; rs34348001; rs300887; rs4144788; rs12991955; rs34933688; rs13407411; rs41371048; rs34592316; rs34213407; rs34146836; rs12474205; rs16822938; rs922731; rs35256698; rs11688020; rs35022988; rs12104910; rs34388312; rs35336295; rs10209574; rs13410856; rs34087191; rs35208422; rs13387701; rs1432532; rs10601832; rs13430558; rs5836836; rs35607749; rs34346085; rs34057444; rs28408366; rs28836623; rs35242356; rs13004142; rs28828218; rs11340321; rs2368275; rs6755854; rs35361731; rs833169; rs16822963; rs10552886; rs36094848; rs34164863; rs13008937; rs4018725; rs1469638; rs1142494; rs7423835; rs300881; rs34889222; rs35002581; rs13013571; rs34988767; rs13424576; rs35852909; rs1595447; rs16822803; rs28666451; rs4144787; rs1070197; rs10688734; rs2438291; rs16823231; rs35368292; rs34226756; rs35220243; rs6760081; rs9711065; rs11399196; rs2082137; rs34920104; rs34966344; rs10713794; rs3209106; rs35811506; rs10931019; rs13400207; rs36105371; rs10177393; rs35509004; rs1978701; rs13415219; rs6760333; rs35831447; rs1142493; rs12999222; rs7606819; rs35650373; rs35320184; rs10557808; rs12996626; rs11408095; rs35174498; rs34076997; rs34640250; rs16822975; rs5836835; rs7423272; rs34245450; rs10203701; rs3063250; rs10188098; rs6147057; rs2436223; rs34863201; rs34103776; rs35115213; rs1196071; rs16822843; rs34713018; rs34586550; rs7425918; rs3835909; rs13013920; rs34863701; rs35574967; rs13424577; rs6761816; rs300886; rs10710872; rs34237746; rs35357239; rs16822827; rs300889; rs3769798; rs10586379; rs2116637; rs866238; rs35885421; rs3063230; rs13384332; rs34509021; rs34758055; rs833121; rs34957815; rs35323523; rs28409316; rs1595444; rs11319157; rs34530868; rs11296923; rs35392282; rs28715871; rs12991803; rs4018724; rs34681555; rs34371581; rs35441240; rs2577653; rs36076255; rs34984539; rs35111823; rs10664174; rs34245807; rs28584604; rs35648980; rs34968173; rs6759848; rs34116983; rs2116636; rs7579614; rs35587614; rs35425419; rs300888; rs34132592; rs35774261; rs34921672; rs34853053; rs35202585; rs36010777; rs35453967; rs2623424; rs10716042; rs11314814; rs34710050; rs34134272; rs35055482; rs35368132; rs7424126; rs34034865; rs13387603; rs13388823; rs35927887; rs36032833; rs11431216; rs35840080; rs10549191; rs28483774; rs9789594; rs13387691; rs13421087; rs34661945; rs10592313; rs34302168; rs34157620; rs34107698; rs28627441; rs4497838; rs11444937; rs12053043; rs2887216; rs12991790; rs3948378; rs5836826; rs34010252; rs862914; rs35884831; rs10170443; rs34823032; rs3063102; rs35502150; rs1837166; rs35617426; rs4992784; rs1871805; rs34343334; rs34450309; rs9653243; rs13420210; rs9798127; rs16823040; rs36202824; rs10597484; rs13013738; rs3830245; rs11300978; rs35182213; rs11351500; rs35809203; rs34641892; rs34558843; rs6725460; rs2116635; rs35245337; rs10617879; rs13026153; rs6719467; rs34326436; rs34145505; rs1142495; rs10668596; rs35156194; rs12472990; rs34384812; rs35828806; rs833161; rs34841932; rs1842639; rs11405472; rs6731653; rs34878038; rs35827784; rs4666821; rs11420821; rs2438289; rs16823144; rs5836837; rs1430149; rs4425048; rs16822903; rs34934165; rs34382403; rs34234948; rs9678855; rs6736970; rs11414637; rs35139583; rs3769799; rs6759212; rs1383900; rs2568686; rs35067674; rs6747943; rs34461180; rs35248394; rs34181578; rs10197337; rs11676428; rs1196057; rs12464556; rs13001068; rs13027181; rs1347081; rs1368217; rs1368218; rs1368219; rs1368220; rs1368221; rs1432528; rs1432529; rs17649232; rs2115863; rs2217616; rs4257360; rs6711862; rs6726543; rs6756014; rs720245; rs7580253; rs7584728; rs7592780

# Metabolic_Enzyme_24_General_References:
8557689; 11342109; 11747989

# Metabolic_Enzyme_24_References:
Not Available

# Metabolic_Enzyme_25_ID:
5872

# Metabolic_Enzyme_25_Name:
cGMP-inhibited 3',5'-cyclic phosphodiesterase A

# Metabolic_Enzyme_25_Synonyms:
Cyclic GMP-inhibited phosphodiesterase A; CGI-PDE A

# Metabolic_Enzyme_25_Gene_Name:
PDE3A

# Metabolic_Enzyme_25_Protein_Sequence:
>cGMPinhibited 3',5'cyclic phosphodiesterase 
AMAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSR
KLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGA
PGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLG
VGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPY
LAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAE
MSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITD
LLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKL
AIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSW
NNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLV
SKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPAD
EPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTY
APETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLF
EDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVI
NDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYD
HPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRF
LVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKE
LHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSA
GLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHL
LQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKP
DQ

# Metabolic_Enzyme_25_Number_of_Residues:
1141

# Metabolic_Enzyme_25_Molecular_Weight:
124980

# Metabolic_Enzyme_25_Theoretical_pI:
5.87

# Metabolic_Enzyme_25_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_25_General_Function:
Not Available

# Metabolic_Enzyme_25_Specific_Function:
Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP)

# Metabolic_Enzyme_25_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_25_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_25_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_25_Signals:
None

# Metabolic_Enzyme_25_Transmembrane_Regions:
61-83; 129-151; 158-180; 184-206; 238-255

# Metabolic_Enzyme_25_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_25_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_25_GenBank_ID_Protein:
38201493

# Metabolic_Enzyme_25_SwissProt_ID:
PDE3A_HUMAN (Q14432)

# Metabolic_Enzyme_25_swissprot_Name:
Not Available

# Metabolic_Enzyme_25_Genecard_id:
PDE3A

# Metabolic_Enzyme_25_Geneatlas_id:
PDE3A

# Metabolic_Enzyme_25_hgnc_id:
HGNC:8778

# Metabolic_Enzyme_25_PDB_ID:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_25_Subcellular_Location:
Membrane; peripheral membrane protein (Potential)

# Metabolic_Enzyme_25_Gene_Sequence:
>3426 bp
ATGGCAGTGCCCGGCGACGCTGCACGAGTCAGGGACAAGCCCGTCCACAGTGGGGTGAGT
CAAGCCCCCACGGCGGGCCGGGACTGCCACCATCGTGCGGACCCCGCATCGCCGCGGGAC
TCGGGCTGCCGTGGCTGCTGGGGAGACCTGGTGCTGCAGCCGCTCCGGAGCTCTCGGAAA
CTTTCCTCCGCGCTGTGCGCGGGCTCCCTATCCTTTCTGCTGGCGCTGCTGGTGAGGCTG
GTCCGCGGGGAGGTCGGCTGTGACCTGGAGCAGTGTAAGGAGGCGGCGGCGGCGGAGGAG
GAGGAAGCAGCCCCGGGAGCAGAAGGGGGCGTCTTCCCGGGGCCTCGGGGAGGTGCTCCC
GGGGGCGGTGCGCGGCTCAGCCCCTGGCTGCAGCCCTCGGCGCTGCTCTTCAGTCTCCTG
TGTGCCTTCTTCTGGATGGGCTTGTACCTCCTGCGCGCCGGGGTGCGCCTGCCTCTGGCT
GTCGCGCTGCTGGCCGCCTGCTGCGGGGGGGAAGCGCTCGTCCAGATTGGGCTGGGCGTC
GGGGAGGATCACTTACTCTCACTCCCCGCTGCGGGGGTGGTGCTCAGCTGCTTGGCCGCC
GCGACATGGCTGGTGCTGAGGCTGAGGCTGGGCGTCCTCATGATCGCCTTGACTAGCGCG
GTCAGGACCGTGTCCCTCATTTCCTTAGAGAGGTTCAAGGTCGCCTGGAGACCTTACCTG
GCGTACCTGGCCGGCGTGCTGGGGATCCTCTTGGCCAGGTACGTGGAACAAATCTTGCCG
CAGTCCGCGGAGGCGGCTCCAAGGGAGCATTTGGGGTCCCAGCTGATTGCTGGGACCAAG
GAAGATATCCCGGTGTTTAAGAGGAGGAGGCGGTCCAGCTCCGTCGTGTCCGCCGAGATG
TCCGGCTGCAGCAGCAAGTCCCATCGGAGGACCTCCCTGCCCTGTATACCGAGGGAACAG
CTCATGGGGCATTCAGAATGGGACCACAAACGAGGGCCAAGAGGATCACAGTCTTCAGGA
ACCAGTATTACTGTGGACATCGCCGTCATGGGCGAAGCCCACGGCCTCATTACCGACCTC
CTGGCAGACCCTTCTCTTCCACCAAACGTGTGCACATCCTTGAGAGCCGTGAGCAACTTG
CTCAGCACACAGCTCACCTTCCAGGCCATTCACAAGCCCAGAGTGAATCCCGTTACTTCG
CTCAGTGAAAACTATACCTGTTCTGACTCTGAAGAGAGCTCTGAAAAAGACAAGCTTGCT
ATTCCAAAGCGCCTGAGAAGGAGTTTGCCTCCTGGCTTGTTGAGACGAGTTTCTTCCACT
TGGACCACCACCACCTCGGCCACAGGTCTACCCACCTTGGAGCCTGCACCAGTACGGAGA
GACCGCAGCACCAGCATCAAACTGCAGGAAGCACCTTCATCCAGTCCTGATTCTTGGAAT
AATCCAGTGATGATGACCCTCACCAAAAGCAGATCCTTTACTTCATCCTATGCTATTTCT
GCAGCTAACCATGTAAAGGCTAAAAAGCAAAGTCGACCAGGTGCCCTCGCTAAAATTTCA
CCTCTTTCATCGCCCTGCTCCTCACCTCTCCAAGGGACTCCTGCCAGCAGCCTGGTCAGC
AAAATTTCTGCAGTGCAGTTTCCAGAATCTGCTGACACAACTGCCAAACAAAGCCTAGGT
TCTCACAGGGCCTTAACTTACACTCAGAGTGCCCCAGACCTATCCCCTCAAATCCTGACT
CCACCTGTTATATGTAGCAGCTGTGGCAGACCATATTCCCAAGGGAATCCTGCTGATGAG
CCCCTGGAGAGAAGTGGGGTAGCCACTCGGACACCAAGTCGAACAGATGACACTGCTCAA
GTTACCTCTGATTATGAAACCAATAACAACAGTGACAGCAGTGACATTGTACAGAATGAA
GATGAAACAGAGTGCCTGAGAGAGCCTCTGAGGAAAGCATCGGCTTGCAGCACCTATGCT
CCTGAGACCATGATGTTTCTGGACAAACCAATTCTTGCTCCCGAACCTCTTGTCATGGAT
AACCTGGACTCAATTATGGAGCAGCTAAATACTTGGAATTTTCCAATTTTTGATTTAGTG
GAAAATATAGGAAGAAAATGTGGCCGTATTCTTAGTCAGGTATCTTACAGACTTTTTGAA
GACATGGGCCTCTTTGAAGCTTTTAAAATTCCAATTAGGGAATTTATGAATTATTTTCAT
GCTTTGGAGATTGGATATAGGGATATTCCTTATCATAACAGAATCCATGCCACTGATGTT
TTACATGCTGTTTGGTATCTTACTACACAGCCTATTCCAGGCCTCTCAACTGTGATTAAT
GATCATGGTTCAACCAGTGATTCAGATTCTGACAGTGGATTTACACATGGACATATGGGA
TATGTATTCTCAAAAACGTATAATGTGACAGATGATAAATACGGATGTCTGTCTGGGAAT
ATCCCTGCCTTGGAGTTGATGGCGCTGTATGTGGCTGCAGCCATGCACGATTATGATCAT
CCAGGAAGGACTAATGCTTTCCTGGTTGCAACTAGTGCTCCTCAGGCGGTGCTATATAAC
GATCGTTCAGTTTTGGAGAATCATCACGCAGCTGCTGCATGGAATCTTTTCATGTCCCGG
CCAGAGTATAACTTCTTAATTAACCTTGACCATGTGGAATTTAAGCATTTCCGTTTCCTT
GTCATTGAAGCAATTTTGGCCACTGACCTGAAGAAACACTTTGACTTCGTAGCCAAATTT
AATGGCAAGGTAAATGATGATGTTGGAATAGATTGGACCAATGAAAATGATCGTCTACTG
GTTTGTCAAATGTGTATAAAGTTGGCTGATATCAATGGTCCAGCTAAATGTAAAGAACTC
CATCTTCAGTGGACAGATGGTATTGTCAATGAATTTTATGAACAGGGTGATGAAGAGGCC
AGCCTTGGATTACCCATAAGCCCCTTCATGGATCGTTCTGCTCCTCAGCTGGCCAACCTT
CAGGAATCCTTCATCTCTCACATTGTGGGGCCTCTGTGCAACTCCTATGATTCAGCAGGA
CTAATGCCTGGAAAATGGGTGGAAGACAGCGATGAGTCAGGAGATACTGATGACCCAGAA
GAAGAGGAGGAAGAAGCACCAGCACCAAATGAAGAGGAAACCTGTGAAAATAATGAATCT
CCAAAAAAGAAGACTTTCAAAAGGAGAAAAATCTACTGCCAAATAACTCAGCACCTCTTA
CAGAACCACAAGATGTGGAAGAAAGTCATTGAAGAGGAGCAACGGTTGGCAGGCATAGAA
AATCAATCCCTGGACCAGACCCCTCAGTCGCACTCTTCAGAACAGATCCAGGCTATCAAG
GAAGAAGAAGAAGAGAAAGGGAAACCAAGAGGCGAGGAGATACCAACCCAAAAGCCAGAC
CAGTGA

# Metabolic_Enzyme_25_GenBank_ID_Gene:
M91667

# Metabolic_Enzyme_25_Chromosome_Location:
Not Available

# Metabolic_Enzyme_25_Locus:
Not Available

# Metabolic_Enzyme_25_SNPs:
Not Available

# Metabolic_Enzyme_25_General_References:
1315035; 8695850

# Metabolic_Enzyme_25_References:
Not Available

# Metabolic_Enzyme_26_ID:
5889

# Metabolic_Enzyme_26_Name:
cGMP-dependent 3',5'-cyclic phosphodiesterase

# Metabolic_Enzyme_26_Synonyms:
Cyclic GMP-stimulated phosphodiesterase; CGS-PDE; cGSPDE

# Metabolic_Enzyme_26_Gene_Name:
PDE2A

# Metabolic_Enzyme_26_Protein_Sequence:
>cGMPdependent 3',5'cyclic phosphodiesterase
MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN
GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV
EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL
DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV
EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD
EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE
ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD
AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF
SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF
ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH
AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS
SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL
QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM
GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH
KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE

# Metabolic_Enzyme_26_Number_of_Residues:
941

# Metabolic_Enzyme_26_Molecular_Weight:
105718

# Metabolic_Enzyme_26_Theoretical_pI:
5.08

# Metabolic_Enzyme_26_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_26_General_Function:
Not Available

# Metabolic_Enzyme_26_Specific_Function:
Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP)

# Metabolic_Enzyme_26_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_26_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_26_Pfam_Domain_Function:
PF01590:GAF;
PF00233:PDEase_I

# Metabolic_Enzyme_26_Signals:
None

# Metabolic_Enzyme_26_Transmembrane_Regions:
None

# Metabolic_Enzyme_26_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_26_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_26_GenBank_ID_Protein:
2108052

# Metabolic_Enzyme_26_SwissProt_ID:
PDE2A_HUMAN (O00408)

# Metabolic_Enzyme_26_swissprot_Name:
Not Available

# Metabolic_Enzyme_26_Genecard_id:
PDE2A

# Metabolic_Enzyme_26_Geneatlas_id:
PDE2A

# Metabolic_Enzyme_26_hgnc_id:
HGNC:8777

# Metabolic_Enzyme_26_PDB_ID:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_26_Subcellular_Location:
Membrane; peripheral membrane protein (Potential)

# Metabolic_Enzyme_26_Gene_Sequence:
>2826 bp
ATGGGGCAGGCATGCGGCCACTCCATCCTCTGCAGGAGCCAGCAGTACCCGGCAGCGCGA
CCGGCTGAGCCGCGGGGCCAGCAGGTCTTCCTCAAGCCGGACGAGCCGCCGCCGCCGCCG
CAGCCATGCGCCGACAGCCTGCAGGACGCCTTGCTGAGTCTGGGCTCTGTCATCGACATT
TCAGGCCTGCAACGTGCTGTCAAGGAGGCCCTGTCAGCTGTGCTCCCCCGAGTGGAAACT
GTCTACACCTACCTACTGGATGGTGAGTCCCAGCTGGTGTGTGAGGACCCCCCACATGAG
CTGCCCCAGGAGGGGAAAGTCCGGGAGGCTATCATCTCCCAGAAGCGGCTGGGCTGCAAT
GGGCTGGGCTTCTCAGACCTGCCAGGGAAGCCCTTGGCCAGGCTGGTGGCTCCACTGGCT
CCTGATACCCAAGTGCTGGTCATGCCGCTAGCGGACAAGGAGGCTGGGGCCGTGGCAGCT
GTCATCTTGGTGCACTGTGGCCAGCTGAGTGATAATGAGGAATGGAGCCTGCAGGCGGTG
GAGAAGCATACCCTGGTCGCCCTGCGGAGGGTGCAGGTCCTGCAGCAGCGCGGGCCCAGG
GAGGCTCCCCGAGCCGTCCAGAACCCCCCGGAGGGGACGGCGGAAGACCAGAAGGGCGGG
GCGGCGTACACCGACCGCGACCGCAAGATCCTCCAACTGTGCGGGGAACTCTACGACCTG
GATGCCTCTTCCCTGCAGCTCAAAGTGCTCCAATACCTGCAGCAGGAGACCCGGGCATCC
CGCTGCTGCCTCCTGCTGGTGTCGGAGGACAATCTCCAGCTTTCTTGCAAGGTCATCGGA
GACAAAGTGCTCGGGGAAGAGGTCAGCTTTCCCTTGACAGGATGCCTGGGCCAGGTGGTG
GAAGACAAGAAGTCCATCCAGCTGAAGGACCTCACCTCCGAGGATGTACAACAGCTGCAG
AGCATGTTGGGCTGTGAGCTGCAGGCCATGCTCTGTGTCCCTGTCATCAGCCGGGCCACT
GACCAGGTGGTGGCCTTGGCCTGCGCCTTCAACAAGCTAGAAGGAGACTTGTTCACCGAC
GAGGACGAGCATGTGATCCAGCACTGCTTCCACTACACCAGCACCGTGCTCACCAGCACC
CTGGCCTTCCAGAAGGAACAGAAACTCAAGTGTGAGTGCCAGGCTCTTCTCCAAGTGGCA
AAGAACCTCTTCACCCACCTGGATGACGTCTCTGTCCTGCTCCAGGAGATCATCACGGAG
GCCAGAAACCTCAGCAACGCAGAGATCTGCTCTGTGTTCCTGCTGGATCAGAATGAGCTG
GTGGCCAAGGTGTTCGACGGGGGCGTGGTGGATGATGAGAGCTATGAGATCCGCATCCCG
GCCGATCAGGGCATCGCGGGACACGTGGCGACCACGGGCCAGATCCTGAACATCCCTGAC
GCATATGCCCATCCGCTTTTCTACCGCGGCGTGGACGACAGCACCGGCTTCCGCACGCGC
AACATCCTCTGCTTCCCCATCAAGAACGAGAACCAGGAGGTCATCGGTGTGGCCGAGCTG
GTGAACAAGATCAATGGGCCATGGTTCAGCAAGTTCGACGAGGACCTGGCGACGGCCTTC
TCCATCTACTGCGGCATCAGCATCGCCCATTCTCTCCTATACAAAAAAGTGAATGAGGCT
CAGTATCGCAGCCACCTGGCCAATGAGATGATGATGTACCACATGAAGGTCTCCGACGAT
GAGTATACCAAACTTCTCCATGATGGGATCCAGCCTGTGGCTGCCATTGACTCCAATTTT
GCAAGTTTCACCTATACCCCTCGTTCCCTGCCCGAGGATGACACGTCCATGGCCATCCTG
AGCATGCTGCAGGACATGAATTTCATCAACAACTACAAAATTGACTGCCCGACCCTGGCC
CGGTTCTGTTTGATGGTGAAGAAGGGCTACCGGGATCCCCCCTACCACAACTGGATGCAC
GCCTTTTCTGTCTCCCACTTCTGCTACCTGCTCTACAAGAACCTGGAGCTCACCAACTAC
CTCGAGGACATCGAGATCTTTGCCTTGTTTATTTCCTGCATGTGTCATGACCTGGACCAC
AGAGGCACAAACAACTCTTTCCAGGTGGCCTCGAAATCTGTGCTGGCTGCGCTCTACAGC
TCTGAGGGCTCCGTCATGGAGAGGCACCACTTTGCTCAGGCCATCGCCATCCTCAACACC
CACGGCTGCAACATCTTTGATCATTTCTCCCGGAAGGACTATCAGCGCATGCTGGATCTG
ATGCGGGACATCATCTTGGCCACAGACCTGGCCCACCATCTCCGCATCTTCAAGGACCTC
CAGAAGATGGCTGAGGTGGGCTACGACCGAAACAACAAGCAGCACCACAGACTTCTCCTC
TGCCTCCTCATGACCTCCTGTGACCTCTCTGACCAGACCAAGGGCTGGAAGACTACGAGA
AAGATCGCGGAGCTGATCTACAAAGAATTCTTCTCCCAGGGAGACCTGGAGAAGGCCATG
GGCAACAGGCCGATGGAGATGATGGACCGGGAGAAGGCCTATATCCCTGAGCTGCAAATC
AGCTTCATGGAGCACATTGCAATGCCCATCTACAAGCTGTTGCAGGACCTGTTCCCCAAA
GCGGCAGAGCTGTACGAGCGCGTGGCCTCCAACCGTGAGCACTGGACCAAGGTGTCCCAC
AAGTTCACCATCCGCGGCCTCCCAAGTAACAACTCGCTGGACTTCCTGGATGAGGAGTAC
GAGGTGCCTGATCTGGATGGCACTAGGGCCCCCATCAATGGCTGCTGCAGCCTTGATGCT
GAGTGA

# Metabolic_Enzyme_26_GenBank_ID_Gene:
U67733

# Metabolic_Enzyme_26_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_26_Locus:
11q13.4

# Metabolic_Enzyme_26_SNPs:
rs341047; rs1135029; rs4944557; rs392565; rs1980091; rs392818; rs11824084; rs458575; rs341087; rs366068; rs371862; rs467139; rs3781913; rs7111188; rs4944584; rs2047506; rs1513780; rs1009708; rs4944643; rs458275; rs11235555; rs341061; rs746399; rs907857; rs11822008; rs189332; rs2035467; rs904469; rs341086; rs11820891; rs11235551; rs907851; rs458437; rs3781931; rs184654; rs426907; rs7934444; rs405851; rs755933; rs11235543; rs7105428; rs376724; rs429075; rs370013; rs907856; rs4943939; rs401801; rs459546; rs4944591; rs462491; rs3825009; rs12363065; rs3781926; rs1038377; rs932074; rs433270; rs455611; rs401999; rs4944608; rs382163; rs7119321; rs11826028; rs10898860; rs10898857; rs755932; rs459309; rs341088; rs676911; rs456405; rs932075; rs1513781; rs676845; rs342326; rs907858; rs4944563; rs341049; rs907850; rs1467135; rs1877652; rs4944639; rs3781916; rs4944635; rs2365774; rs424234; rs1391888; rs342321; rs4943961; rs11603497; rs11828329; rs3781939; rs11235548; rs457556; rs341085; rs460633; rs2365769; rs399874; rs168173; rs90409; rs3781923; rs7930245; rs10793036; rs377432; rs754042; rs458360; rs462177; rs11821068; rs171021; rs3781932; rs341052; rs11235559; rs10898861; rs402250; rs572421; rs428355; rs7115561; rs408269; rs342322; rs1980090; rs7126790; rs341048; rs10898855; rs1980089; rs341059; rs11235557; rs11823678; rs12804316; rs4944599; rs11602224; rs10898856; rs3842265; rs11235558; rs341051; rs10793037; rs878277; rs12290945; rs1513779; rs10898858; rs342327; rs7108786; rs163692; rs7108477; rs455631; rs17162381; rs341050; rs11604837; rs236034; rs877133; rs907849; rs459886; rs163693; rs2365773; rs12797791; rs12797368; rs3781938; rs644698; rs462720; rs464853; rs341089; rs12146545; rs11604034; rs577536; rs3741159; rs11235550; rs11605051; rs4944589; rs11600831; rs11235547; rs17162383; rs1079117; rs11602616; rs11601122; rs371903; rs341039; rs466023; rs341060; rs11235546; rs7924891; rs371412; rs409816; rs907854; rs168175; rs11235552; rs17162385; rs12289096; rs2280098; rs414178; rs466929; rs12797628; rs7946369; rs7926573; rs151449; rs10751207; rs342323; rs11824863; rs11826928; rs907853; rs3781934; rs7111810; rs452228; rs11235549; rs1391887; rs341035; rs7123699; rs3781933; rs415399; rs341058; rs402479; rs3758936; rs3758935; rs443510; rs17857242; rs17854062; rs1056864; rs34999278; rs1299161; rs35034069; rs1056859; rs36006389; rs35330308; rs1695326; rs10629768; rs35374828; rs10599676; rs11235556; rs11235563; rs2648427; rs11235544; rs34217943; rs465873; rs11235560; rs180539; rs3842266; rs34273765; rs34673418; rs1467134; rs35973297; rs34219591; rs379638; rs415603; rs12276767; rs34845765; rs7111915; rs11235542; rs36088997; rs163608; rs2037030; rs7110834; rs35791363; rs12800996; rs341084; rs12291404; rs3825011; rs11235562; rs35209015; rs34659576; rs390130; rs34678444; rs5792598; rs34885656; rs631552; rs28435513; rs35457068; rs34561755; rs34903353; rs1079116; rs33965768; rs34055117; rs7941968; rs28681095; rs367195; rs341062; rs3781937; rs7930640; rs3837412; rs3781915; rs34720752; rs366711; rs236908; rs12362256; rs35491439; rs34815390; rs10751208; rs35179366; rs10577236; rs34468837; rs341038; rs7110760; rs1513782; rs3741160; rs11235545; rs11421754; rs34212074; rs34648431; rs3741158; rs7933910; rs459854; rs33948641; rs12787971; rs341037; rs7128760; rs12805517; rs34992676; rs34755048; rs35351102; rs4944570; rs5792597; rs12420120; rs34958282; rs3781924; rs12796885; rs384892; rs12223388; rs36025018; rs7482093; rs34346276; rs12789554; rs11824399; rs34173798; rs12275807; rs12293769; rs10552751; rs7935955; rs34927568; rs35642115; rs12276624; rs4944566; rs35534137; rs11603077; rs12790170; rs465512; rs34193719; rs3832776; rs35014697; rs168174; rs12280849; rs7110717; rs438969; rs2271524; rs3837413; rs342320; rs907855; rs36022812; rs35320110; rs12279246; rs10533778; rs35814877; rs35309746; rs12287467; rs7123937; rs7115954; rs379276; rs12276229; rs10666854; rs2128913; rs3062165; rs6144389; rs394903; rs10706560; rs12099061; rs341036; rs34274987; rs34893653; rs4990737; rs1681502; rs35905219; rs11605720; rs34977751; rs7951461; rs34098578; rs10636062; rs35667827; rs35562683; rs11235553; rs5792596; rs11362512; rs34720227; rs35148742; rs456119; rs12281128; rs11235561; rs35057014; rs34150026; rs35365831; rs12290975; rs12786089; rs34706617; rs35360874; rs341057; rs186882; rs11235541; rs35255183; rs11235540; rs11235565; rs11604811; rs11823971; rs12421911; rs12576046; rs12576058; rs12787293; rs12799451; rs1473885; rs163694; rs341054; rs341056; rs34285624; rs35730889; rs365274; rs366066; rs3758934; rs380126; rs387354; rs393479; rs393561; rs409512; rs433640; rs433837; rs6592481; rs670066; rs7104461; rs7117518; rs7952279

# Metabolic_Enzyme_26_General_References:
9210593

# Metabolic_Enzyme_26_References:
Not Available

# Metabolic_Enzyme_27_ID:
5854

# Metabolic_Enzyme_27_Name:
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

# Metabolic_Enzyme_27_Synonyms:
cGMP phosphodiesterase 6C

# Metabolic_Enzyme_27_Gene_Name:
PDE6C

# Metabolic_Enzyme_27_Protein_Sequence:
>Cone cGMPspecific 3',5'cyclic phosphodiesterase subunit alpha'
MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESA
LCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPT
SKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLL
ATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRS
QILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGE
VEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICN
MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEY
ITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVD
VIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKV
PVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF
CHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET
VIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMT
ACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFI
DFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKA
AEDSGGGDDKKSKTCLML

# Metabolic_Enzyme_27_Number_of_Residues:
858

# Metabolic_Enzyme_27_Molecular_Weight:
99148

# Metabolic_Enzyme_27_Theoretical_pI:
5.45

# Metabolic_Enzyme_27_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_27_General_Function:
Not Available

# Metabolic_Enzyme_27_Specific_Function:
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate

# Metabolic_Enzyme_27_Pathway:
Not Available

# Metabolic_Enzyme_27_Reaction:
guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate

# Metabolic_Enzyme_27_Pfam_Domain_Function:
PF01590:GAF;
PF00233:PDEase_I

# Metabolic_Enzyme_27_Signals:
None

# Metabolic_Enzyme_27_Transmembrane_Regions:
None

# Metabolic_Enzyme_27_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_27_EC_Link:
EC 3.1.4.35

# Metabolic_Enzyme_27_GenBank_ID_Protein:
940231

# Metabolic_Enzyme_27_SwissProt_ID:
PDE6C_HUMAN (P51160)

# Metabolic_Enzyme_27_swissprot_Name:
Not Available

# Metabolic_Enzyme_27_Genecard_id:
PDE6C

# Metabolic_Enzyme_27_Geneatlas_id:
PDE6C

# Metabolic_Enzyme_27_hgnc_id:
HGNC:8787

# Metabolic_Enzyme_27_PDB_ID:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_27_Subcellular_Location:
Cell membrane; lipid-anchor; cytoplasmic side (Potential)

# Metabolic_Enzyme_27_Gene_Sequence:
>2577 bp
ATGGGTGAGATCAACCAAGTTGCCGTGGAGAAATACCTGGAGGAGAACCCTCAGTTTGCC
AAGGAGTACTTTGACAGGAAGTTGCGGGTGGAGGTGCTGGGAGAAATCTTCAAGAACAGC
CAGGTGCCAGTCCAGTCCAGCATGTCCTTCTCTGAGCTGACCCAGGTGGAGGAGTCAGCC
CTGTGCTTGGAGCTGCTGTGGACCGTGCAGGAGGAGGGGGGCACCCCAGAGCAGGGGGTT
CACAGGGCCCTACAGAGGCTGGCCCACCTGCTCCAGGCTGACCGCTGCAGCATGTTCCTG
TGCCGGTCCCGGAACGGCATACCTGAGGTGGCCTCTAGGTTGCTGGTAGTCACCCCCACC
TCCAAGTTTGAGGACAACCTGGTGGGCCCTGACAAAGAAGTTGTGTTTCCATTGGACATT
GGGATAGTGGGTTGGGCTGCTCACACGAAGAAAACTCATAATGTCCCAGATGTGAAAAAG
AACAGCCATTTTTCTGACTTCATGGACAAGCAAACTGGGTATGTCACTAAGAACCTGCTG
GCAACCCCGATCGTGGTGGGCAAGGAGGTTCTTGCTGTGATCATGGCAGTTAACAAAGTA
AATGCATCTGAATTTTCCAAACAGGATGAAGAGGTCTTTTCCAAATACCTCAACTTTGTG
TCTATCATCCTAAGGCTTCATCACACCAGCTACATGTACAATATTGAATCCCGAAGAAGC
CAGATCCTTATGTGGTCAGCCAATAAAGTATTTGAAGAACTCACAGATGTTGAGCGACAG
TTTCACAAAGCGCTCTACACGGTTAGATCATATCTGAACTGTGAACGATACTCCATTGGA
CTGCTGGACATGACCAAGGAGAAGGAATTCTACGATGAATGGCCAATCAAGCTTGGAGAA
GTAGAGCCTTATAAAGGTCCAAAGACACCTGATGGCAGGGAAGTCAACTTTTATAAAATC
ATTGATTACATTTTACATGGAAAAGAAGAGATCAAAGTGATTCCGACGCCTCCTGCAGAC
CACTGGACACTCATTAGTGGGTTGCCAACATATGTTGCTGAAAATGGATTTATCTGTAAC
ATGATGAATGCCCCTGCGGATGAATACTTCACATTTCCGAAAGGACCTGTAGACGAAACT
GGTTGGGTCATTAAGAATGTTTTGTCCCTGCCTATTGTCAACAAGAAAGAAGATATTGTG
GGAGTGGCTACATTTTACAACAGGAAGGATGGAAAACCTTTCGATGAGCATGATGAATAC
ATTACCGAGACTCTCACACAATTTCTTGGATGGTCTCTTTTAAATACTGACACCTACGAT
AAGATGAATAAGCTAGAAAACAGAAAGGACATTGCTCAGGAAATGCTCATGAACCAAACC
AAAGCCACTCTTGAAGAAATTAAGTCCATTTTGAAATTTCAAGAGAAGTTAAATGTTGAT
GTAATTGACGACTGTGAAGAAAAACAACTTGTTGCAATTTTGAAAGAGGACTTGCCAGAC
CCACGCTCAGCAGAACTGTACGAATTCCGCTTCAGTGACTTCCCCCTTACAGAGCACGGA
TTGATTAAATGTGGAATACGACTGTTTTTTGAAATAAATGTGGTGGAGAAATTCAAAGTA
CCTGTAGAGGTTCTTACCAGATGGATGTACACTGTGAGGAAAGGGTACCGAGCTGTCACT
TACCACAATTGGCAGCATGGGTTCAACGTGGGGCAGACCATGTTTACTTTGCTGATGACA
GGAAGATTAAAGAAGTACTACACAGATCTCGAAGCCTTTGCCATGCTTGCTGCTGCTTTC
TGCCATGATATTGACCACAGAGGCACCAATAATTTGTACCAGATGAAATCCACGTCTCCA
TTAGCAAGACTTCATGGTTCTTCTATTTTGGAGAGGCACCACCTGGAGTACAGTAAGACT
CTGTTGCAGGATGAGAGTTTAAACATCTTCCAGAACCTAAATAAGCGGCAGTTTGAAACA
GTTATTCATTTGTTCGAGGTCGCAATAATAGCAACTGACCTGGCTTTATATTTCAAGAAG
AGGACCATGTTTCAAAAAATTGTTGATGCCTGTGAACAAATGCAAACGGAAGAAGAAGCC
ATCAAATATGTAACTGTTGATCCAACCAAGAAAGAGATTATCATGGCAATGATGATGACG
GCATGTGACTTGTCTGCTATTACCAAGCCCTGGGAGGTGCAAAGTCAGGTAGCACTTATG
GTTGCAAATGAATTTTGGGAACAAGGAGATCTGGAGAGAACAGTGTTGCAGCAACAACCC
ATTCCTATGATGGACAGAAACAAAAGAGATGAATTACCTAAACTTCAAGTTGGATTTATT
GATTTTGTTTGTACTTTTGTATATAAGGAGTTCTCACGGTTTCACAAAGAAATCACACCT
ATGCTGAGTGGTCTTCAGAATAACAGAGTAGAATGGAAATCACTAGCTGATGAGTATGAT
GCAAAGATGAAGGTCATTGAAGAGGAGGCAAAAAAGCAAGAAGGAGGAGCCGAAAAAGCT
GCTGAAGATTCAGGAGGTGGTGATGACAAAAAGTCCAAAACATGTTTAATGTTGTAA

# Metabolic_Enzyme_27_GenBank_ID_Gene:
U31973

# Metabolic_Enzyme_27_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_27_Locus:
10q24

# Metabolic_Enzyme_27_SNPs:
rs701865; rs714550; rs3737228; rs1131978; rs12781149; rs554062; rs650058; rs588912; rs2077733; rs616522; rs637959; rs1326217; rs1223306; rs2422324; rs487161; rs1409332; rs716333; rs2104497; rs2422326; rs591392; rs2857300; rs1147644; rs1018634; rs913046; rs7080485; rs829107; rs2785137; rs6583900; rs720298; rs725888; rs10786119; rs4917871; rs10882289; rs503758; rs11187554; rs2857293; rs604489; rs12266365; rs10748607; rs481031; rs3781273; rs2901714; rs7903947; rs620043; rs1147645; rs677517; rs7095788; rs1147643; rs640090; rs3824752; rs1326219; rs583830; rs1223308; rs10786121; rs10882291; rs714549; rs12249716; rs716332; rs2275227; rs473934; rs517785; rs4919340; rs829109; rs7919662; rs7080650; rs1409334; rs11187570; rs17485621; rs559590; rs618951; rs659145; rs564626; rs547759; rs10882294; rs1326218; rs3781279; rs620890; rs10882288; rs1764322; rs7076251; rs714551; rs10882292; rs11187574; rs6583901; rs2422327; rs11187573; rs2765828; rs12412552; rs12264082; rs590226; rs1409335; rs10882293; rs1409333; rs1223307; rs17109153; rs10882297; rs17109017; rs2148295; rs2094210; rs9419777; rs12260939; rs10882298; rs12265671; rs1856563; rs1147642; rs2148296; rs515656; rs17109134; rs12252727; rs4919314; rs2184777; rs2014325; rs7476647; rs10882287; rs11187560; rs17109081; rs11187575; rs17407606; rs17109131; rs2785140; rs10882296; rs12261871; rs7075895; rs10882290; rs7097667; rs7095955; rs11814998; rs7917510; rs11187566; rs11187572; rs11187555; rs7893369; rs12217346; rs12261990; rs11187578; rs6583903; rs2857302; rs2422325; rs2785144; rs11187571; rs7910799; rs4454655; rs11187577; rs11187563; rs12217337; rs11187556; rs2009687; rs11814382; rs4919339; rs1223305; rs7094543; rs1223295; rs12246423; rs11187561; rs11187569; rs4282926; rs11187564; rs10786120; rs7893372; rs1223309; rs12251269; rs11187562; rs1096025; rs6583902; rs4919344; rs12252137; rs12266501; rs12260671; rs11597224; rs12261131; rs41290222; rs1051925; rs1051926; rs2785143; rs34556446; rs35991228; rs2785136; rs1934332; rs12244942; rs7091068; rs12780304; rs35383563; rs2857298; rs35646712; rs2857296; rs685932; rs11458791; rs12220088; rs1223296; rs11187559; rs11187568; rs2184776; rs2785142; rs10576959; rs2859742; rs3781276; rs2859743; rs12784096; rs2857297; rs11187576; rs4322325; rs7901817; rs2857295; rs12246400; rs3781272; rs3831275; rs7100627; rs11187553; rs2785138; rs5787071; rs35142602; rs35544970; rs35302473; rs7897417; rs7084398; rs36000137; rs35178949; rs2765830; rs10691352; rs11187565; rs514120; rs1934333; rs2785139; rs7900772; rs34173771; rs2765831; rs10680592; rs4919390; rs35484151; rs1750634; rs34507085; rs7903992; rs12049686; rs35175655; rs7909769; rs34414687; rs4539248; rs4590795; rs35868180; rs10666338; rs36102645; rs35822924; rs7904127; rs10699606; rs2484928; rs587034; rs1096027; rs5787069; rs12254107; rs34756107; rs3904734; rs3085185; rs35818357; rs11364728; rs2857301; rs34861265; rs1096026; rs2765829; rs7907905; rs11187557; rs11418985; rs10548834; rs34919813; rs4558100; rs11187552; rs12220915; rs34008461; rs634750; rs34327978; rs4917865; rs34108261; rs2857299; rs35656775; rs3085187; rs474709; rs41303821; rs12412251; rs1326216; rs1013889; rs11187558; rs2785134; rs35245452; rs7475724; rs12779737; rs12260900; rs2857294; rs2785133; rs12260745; rs9419778; rs12260744; rs10159893; rs10786117; rs1108197; rs11187549; rs11187579; rs11187580; rs12219497; rs12255765; rs12265776; rs12415773; rs12573026; rs1326215; rs1547173; rs1572772; rs1572773; rs17108993; rs17108996; rs17486669; rs34803976; rs35180415; rs3740369; rs3765581; rs4144098; rs7904844; rs913045

# Metabolic_Enzyme_27_General_References:
7490077

# Metabolic_Enzyme_27_References:
Not Available

# Metabolic_Enzyme_28_ID:
5983

# Metabolic_Enzyme_28_Name:
Adenylate cyclase type 3

# Metabolic_Enzyme_28_Synonyms:
Adenylate cyclase type III; ATP pyrophosphate-lyase 3; Adenylyl cyclase 3; AC-III; AC3; Adenylate cyclase, olfactive type

# Metabolic_Enzyme_28_Gene_Name:
ADCY3

# Metabolic_Enzyme_28_Protein_Sequence:
>Adenylate cyclase type 3
MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPE
SLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLDII
LFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFF
ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVG
IMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDES
QKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQ
LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTV
LGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCD
YLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHS
SGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESA
QVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTN
YVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMAN
VVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLM
LLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKY
SMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHV
ARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFD
SLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFA
LAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVM
GNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTLPHQV
VDNS

# Metabolic_Enzyme_28_Number_of_Residues:
1144

# Metabolic_Enzyme_28_Molecular_Weight:
128962

# Metabolic_Enzyme_28_Theoretical_pI:
6.55

# Metabolic_Enzyme_28_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  phosphorus-oxygen lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  cyclic nucleotide biosynthesis
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_28_General_Function:
Signal transduction mechanisms 

# Metabolic_Enzyme_28_Specific_Function:
Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration

# Metabolic_Enzyme_28_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_28_Reaction:
ATP = 3',5'-cyclic AMP + diphosphate

# Metabolic_Enzyme_28_Pfam_Domain_Function:
PF00211:Guanylate_cyc

# Metabolic_Enzyme_28_Signals:
None

# Metabolic_Enzyme_28_Transmembrane_Regions:
80-100
105-125
139-159
173-193
226-246
381-401
633-653
664-684
708-728
754-774
775-795
833-853

# Metabolic_Enzyme_28_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_28_EC_Link:
EC 4.6.1.1

# Metabolic_Enzyme_28_GenBank_ID_Protein:
4104226

# Metabolic_Enzyme_28_SwissProt_ID:
ADCY3_HUMAN (O60266)

# Metabolic_Enzyme_28_swissprot_Name:
Not Available

# Metabolic_Enzyme_28_Genecard_id:
ADCY3

# Metabolic_Enzyme_28_Geneatlas_id:
ADCY3

# Metabolic_Enzyme_28_hgnc_id:
HGNC:234

# Metabolic_Enzyme_28_PDB_ID:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_28_Subcellular_Location:
Membrane; multi-pass membrane protein

# Metabolic_Enzyme_28_Gene_Sequence:
>3435 bp
ATGCCGAGGAACCAGGGCTTCTCCGAGCCCGAATACTCGGCCGAGTACTCAGCCGAGTAC
TCCGTCAGCCTGCCCTCCGACCCTGACCGCGGGGTGGGCCGGACCCATGAAATCTCGGTC
CGGAACTCGGGCTCCTGCCTGTGCCTGCCTCGCTTCATGCGGCTGACTTTCGTGCCGGAG
TCCTTGGAGAACCTCTACCAGACCTACTTCAAAAGGCAGCGCCACGAGACCCTGCTGGTG
CTGGTGGTCTTTGCAGCCCTCTTTGACTGCTACGTGGTGGTCATGTGTGCTGTGGTCTTC
TCCAGCGACAAGCTGGCTCCCCTCGCCGTGGCTGGAATTGGACTGGTGTTGGACATCATC
CTCTTCGTGCTCTGCAAAAAGGGGCTGCTCCCGGACCGGGTCACCCGCAGAGTGCTGCCC
TACGTGCTGTGGCTGCTCATAACCGCCCAGATCTTCTCCTACCTGGGCCTGAACTTCGCG
CGTGCCCACGCGGCTAGTGACACGGTGGGCTGGCAGGTCTTCTTTGTCTTCTCCTTCTTC
ATCACGCTGCCCCTCAGCCTCAGCCCCATCGTGATCATCTCCGTGGTCTCCTGTGTGGTG
CACACGTTGGTCCTGGGGGTCACCGTGGCCCAGCAGCAGCAGGAGGAGCTCAAGGGGATG
CAGCTGCTGCGGGAGATCCTGGCCAACGTCTTCCTCTACCTGTGCGCCATCGCTGTGGGC
ATCATGTCCTACTACATGGCTGACCGCAAGCACCGCAAGGCCTTCCTGGAGGCCCGCCAG
TCGCTGGAGGTGAAGATGAACCTGGAAGAGCAGAGCCAGCAGCAGGAGAACCTCATGCTT
TCCATCCTGCCCAAGCACGTGGCTGACGAGATGCTGAAAGACATGAAGAAAGACGAGAGC
CAGAAGGACCAGCAGCAGTTCAACACCATGTACATGTACCGTCACGAGAACGTCAGCATC
CTCTTTGCCGACATCGTGGGCTTTACCCAGCTGTCTTCTGCCTGCAGTGCCCAGGAGCTT
GTGAAGCTGCTCAACGAGCTCTTTGCCCGCTTTGACAAGCTGGCAGCTAAATACCACCAG
CTGCGGATTAAGATCCTGGGCGACTGCTACTACTGCATCTGCGGCTTGCCTGACTACCGG
GAGGACCACGCCGTCTGCTCCATCCTCATGGGGCTGGCCATGGTGGAGGCCATCTCGTAT
GTGCGGGAGAAGACCAAGACTGGGGTGGACATGCGTGTGGGGGTGCACACGGGCACCGTG
CTGGGGGGCGTCCTGGGCCAGAAGCGCTGGCAGTACGACGTGTGGTCGACTGATGTCACT
GTAGCCAACAAGATGGAGGCCGGCGGCATCCCTGGGCGCGTGCACATCTCCCAGAGCACC
ATGGACTGCCTGAAAGGGGAGTTTGATGTGGAGCCAGGCGATGGGGGCAGCCGCTGTGAT
TACCTAGAAGAGAAGGGTATTGAAACCTACCTCATCATTGCCTCCAAGCCAGAGGTGAAG
AAAACAGCCACCCAGAATGGCCTCAATGGCTCGGCCCTGCCCAATGGAGCACCAGCTTCC
TCAAAGTCCAGCTCCCCTGCCCTCATTGAGACCAAGGAGCCCAACGGGAGTGCCCACAGC
AGTGGGTCCACGTCGGAGAAGCCCGAGGAGCAGGATGCCCAGGCCGACAACCCCTCATTC
CCCAACCCACGCCGGAGGCTGCGCCTGCAGGACCTGGCTGACCGAGTGGTGGATGCCTCT
GAAGATGAGCACGAGCTCAACCAGCTGCTCAACGAGGCCCTGCTTGAGCGAGAGTCCGCC
CAAGTAGTAAAGAAGAGAAACACCTTCCTCTTGTCCATGCGGTTCATGGACCCCGAGATG
GAAACCCGCTACTCGGTGGAGAAGGAGAAGCAGAGTGGGGCTGCCTTCAGCTGCTCCTGC
GTCGTCCTGCTCTGCACGGCCCTGGTCGAGATACTCATCGACCCCTGGCTAATGACAAAC
TATGTGACCTTCATGGTGGGGGAGATTCTGCTCCTCATCCTGACCATCTGCTCCCTGGCT
GCCATCTTTCCCCGGGCCTTTCCTAAGAAGCTTGTGGCCTTCTCAACTTGGATTGACCGG
ACCCGCTGGGCCAGGAACACCTGGGCCATGCTCGCCATCTTCATCCTGGTGATGGCAAAT
GTCGTGGACATGCTCAGCTGTCTCCAGTACTACACGGGACCCAGCAATGCAACGGCAGGG
ATGGAGACGGAGGGCAGCTGCCTGGAGAACCCCAAGTATTACAACTATGTGGCCGTGCTG
TCCCTCATCGCCACCATCATGCTGGTGCAGGTCAGCCACATGGTGAAGCTCACGCTCATG
CTGCTCGTCGCAGGCGCCGTGGCCACCATCAACCTCTATGCCTGGCGTCCCGTCTTTGAT
GAATACGACCACAAGCGTTTTCGGGAGCACGACTTACCTATGGTGGCCTTAGAGCAGATG
CAAGGATTCAACCCTGGGCTCAATGGCACTGACAGGCTGCCCCTGGTGCCTTCCAAGTAC
TCTATGACGGTGATGGTGTTCCTCATGATGCTCAGCTTCTACTACTTCTCCCGCCACGTA
GAAAAACTGGCACGGACACTTTTCTTGTGGAAGATTGAGGTCCACGACCAGAAGGAACGT
GTCTATGAGATGCGACGCTGGAACGAGGCCTTGGTCACCAACATGTTGCCTGAGCACGTG
GCACGCCATTTCCTGGGGTCCAAGAAGAGAGATGAGGAGCTGTATAGCCAGACGTATGAT
GAGATTGGAGTCATGTTTGCCTCCCTGCCCAACTTTGCTGACTTCTACACAGAGGAGAGC
ATCAACAATGGTGGTATTGAGTGTCTGCGTTTCCTCAATGAAATCATCTCAGATTTTGAC
TCTCTCCTGGACAATCCCAAGTTCCGGGTGATCACCAAGATCAAAACCATTGGCAGCACG
TATATGGCGGCTTCAGGAGTCACCCCCGATGTCAACACCAATGGCTTTGCCAGCTCCAAC
AAGGAAGACAAGTCCGAGAGAGAGCGCTGGCAGCACCTGGCTGACCTGGCCGACTTCGCG
CTGGCCATGAAGGATACGCTCACCAACATCAACAACCAGTCCTTCAATAACTTCATGCTG
CGCATAGGCATGAACAAAGGCGGGGTTCTGGCTGGGGTCATCGGAGCCCGGAAACCACAC
TACGACATCTGGGGCAATACAGTCAATGTAGCCAGCAGGATGGAGTCCACGGGGGTCATG
GGCAACATTCAGGTGGTAGAAGAAACCCAAGTCATCCTCCGAGAGTACGGCTTCCGCTTT
GTGAGGCGAGGCCCCATCTTTGTGAAGGGGAAGGGGGAGCTGCTGACCTTCTTCTTGAAG
GGGCGGGATAAGCTAGCCACCTTCCCCAATGGCCCCTCTGTCACACTGCCCCACCAGGTG
GTGGACAACTCCTGA

# Metabolic_Enzyme_28_GenBank_ID_Gene:
AF033861

# Metabolic_Enzyme_28_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_28_Locus:
2p24-p22

# Metabolic_Enzyme_28_SNPs:
rs1127568; rs2241759; rs2241758; rs7566416; rs2033654; rs2384059; rs2033655; rs2033653; rs1865689; rs6545789; rs7576788; rs11688665; rs6712981; rs6545800; rs6752483; rs6545809; rs4077677; rs6706316; rs7597332; rs10203386; rs6545758; rs11675457; rs11900505; rs6756609; rs6545782; rs6723803; rs6545812; rs11683212; rs7597157; rs12713419; rs2384058; rs1056074; rs6733224; rs11885385; rs6545790; rs6545807; rs6732140; rs4077678; rs13387729; rs934608; rs6545781; rs6713978; rs6724772; rs7608185; rs10198275; rs6545776; rs13407913; rs6760328; rs13410999; rs6545814; rs6545808; rs3198665; rs2384061; rs6721750; rs7591460; rs916485; rs7565468; rs10200566; rs10164842; rs1541984; rs10184813; rs916484; rs11687089; rs6722587; rs10171663; rs6718628; rs1965122; rs11684619; rs10207698; rs3198667; rs7573439; rs6736711; rs1865687; rs6545813; rs7593130; rs7608976; rs11683929; rs7576172; rs1550110; rs1968482; rs7560156; rs2384056; rs6545766; rs11685125; rs6722341; rs6741116; rs6735578; rs6705446; rs753529; rs6717671; rs6749170; rs10186242; rs4560065; rs7565460; rs11888690; rs7567997; rs2289090; rs10207900; rs916486; rs10187348; rs11889210; rs1344840; rs11686663; rs4077679; rs6737082; rs11683266; rs17046683; rs11678026; rs10176566; rs13382979; rs17738465; rs7586879; rs6730191; rs17046737; rs10203482; rs11892869; rs2384057; rs11688754; rs6712986; rs17799872; rs10165451; rs7602276; rs11683429; rs6721461; rs10195271; rs1529897; rs3903070; rs4665273; rs7580081; rs13394814; rs17046666; rs11689546; rs6726199; rs1865688; rs13398155; rs2033656; rs12105415; rs6736210; rs9309329; rs6545806; rs9631061; rs2278485; rs11675013; rs10865315; rs11884570; rs4077680; rs10164466; rs1058064; rs6725517; rs13404163; rs13387053; rs13409486; rs6545795; rs11895986; rs2384055; rs10198356; rs13012304; rs6722726; rs4665728; rs6717398; rs2289088; rs6723610; rs1814391; rs7604576; rs10174476; rs934611; rs12986610; rs4665726; rs2289091; rs11681161; rs11690467; rs10190584; rs11693654; rs17046711; rs1077641; rs11689543; rs7600421; rs17800401; rs6723199; rs12615954; rs4665274; rs6751533; rs6759962; rs2278486; rs11125810; rs7603153; rs6722022; rs6755554; rs13432743; rs13386646; rs13412941; rs2278484; rs10196998; rs7604178; rs12713422; rs11675198; rs6721413; rs1056075; rs17046717; rs876186; rs13390269; rs4665727; rs11125816; rs11683748; rs17046668; rs13428821; rs6754997; rs6545810; rs9631062; rs10179794; rs10172886; rs6759469; rs12619015; rs11125803; rs11125825; rs4665725; rs4665733; rs2241757; rs10205326; rs13428763; rs934610; rs7576314; rs11125802; rs6743996; rs13019149; rs7575342; rs6738493; rs11689042; rs10206196; rs6719064; rs1077642; rs2033652; rs4275988; rs2289092; rs41289508; rs41289506; rs7571974; rs10176464; rs35348525; rs11433494; rs36176963; rs13035239; rs7602614; rs5829945; rs4665730; rs35177510; rs34816357; rs11896954; rs33962880; rs4998721; rs7563204; rs35769073; rs1806822; rs13404646; rs35743522; rs3214643; rs11363174; rs10165923; rs6718511; rs13029852; rs28653169; rs13007196; rs10204918; rs1344838; rs4413119; rs4530319; rs11288299; rs10631430; rs34842915; rs35669704; rs6755363; rs11125826; rs34029858; rs11691159; rs35545637; rs11353136; rs5829943; rs11692214; rs4665732; rs35033157; rs34239260; rs34017360; rs13016223; rs10525109; rs36071142; rs10701749; rs36061014; rs35100474; rs12185544; rs35242892; rs13005690; rs6146686; rs13005072; rs12990655; rs13388836; rs34110744; rs10613690; rs6723389; rs35825710; rs2033651; rs34585862; rs35993970; rs13383956; rs10664989; rs34450499; rs13026943; rs34341651; rs2082878; rs13392560; rs35633097; rs35703777; rs28836469; rs4558546; rs35877584; rs7583654; rs7557889; rs13014100; rs35439727; rs35429899; rs13012872; rs12469071; rs5829949; rs13428789; rs35249221; rs4998722; rs5829947; rs35700372; rs5829941; rs11382204; rs35234721; rs36029941; rs6761804; rs1143170; rs35945966; rs10550392; rs34728703; rs35609705; rs6744205; rs13431541; rs35728818; rs13393512; rs11445039; rs11885045; rs36005076; rs3214642; rs13003430; rs11380807; rs10210642; rs35766802; rs35450572; rs1541983; rs34570513; rs36048912; rs33920789; rs2164410; rs34720396; rs6718510; rs10700697; rs10565117; rs35868060; rs12052322; rs12620601; rs1435880; rs10566562; rs11381166; rs13006993; rs4665731; rs10572866; rs10187355; rs33914458; rs28560299; rs13030692; rs2384060; rs35323901; rs5829944; rs34234513; rs6713448; rs7599796; rs11276021; rs35705876; rs10617298; rs34697209; rs10207393; rs3037312; rs3841556; rs11274757; rs13035244; rs10207642; rs5829948; rs10565041; rs35803386; rs11677879; rs10175064; rs34927798; rs34917511; rs13416733; rs7605335; rs2289087; rs10181147; rs10187358; rs34976109; rs3037308; rs34488542; rs13029825; rs35149146; rs35422751; rs6710696; rs10651478; rs13421692; rs10707204; rs34982097; rs6753096; rs34158764; rs10616365; rs10577242; rs3179014; rs7582560; rs13394377; rs36083373; rs6725689; rs11308691; rs1077640; rs3037273; rs13029441; rs13423543; rs34058122; rs35379238; rs34823571; rs11900891; rs34987519; rs10603465; rs4297837; rs10182036; rs34685288; rs11677299; rs34715146; rs34780272; rs36007978; rs4665729; rs13405505; rs34333475; rs1344839; rs5829946; rs35530633; rs6751537; rs34946506; rs11896955; rs35610206; rs35939542; rs35072958; rs10211453; rs1143171; rs11688862; rs41281519; rs6746013; rs34134504; rs34101317; rs1003064; rs10178539; rs10182181; rs10208038; rs1044040; rs11125797; rs1127637; rs11676272; rs11895026; rs13021319; rs1550114; rs1550115; rs1802121; rs2099505; rs2278482; rs2278483; rs2608; rs34788696; rs35707695; rs4429431; rs6719538; rs6720845; rs6722683; rs6749422; rs6752378; rs874162; rs934609

# Metabolic_Enzyme_28_General_References:
9920776; 9628581; 8476432

# Metabolic_Enzyme_28_References:
Not Available

# Metabolic_Enzyme_29_ID:
5877

# Metabolic_Enzyme_29_Name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

# Metabolic_Enzyme_29_Synonyms:
Cam-PDE 1C; hCam-3

# Metabolic_Enzyme_29_Gene_Name:
PDE1C

# Metabolic_Enzyme_29_Protein_Sequence:
>Calcium/calmodulindependent 3',5'cyclic nucleotide phosphodiesterase 1
CMESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVV
DLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLR
RSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEA
SGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQT
VHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLEN
HHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQP
EAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRK
STMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAK
RSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKA
RLAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSG
EQQQNGDFKDGKNKTDKKDHSNIGNDSKKTDGTKQRSHGSPAPSTSSTCRLTLPVIKPPL
RHFKRPAYASSSYAPSVSKKTDEHPARYKMLDQRIKMKKIQNISHNWNRK

# Metabolic_Enzyme_29_Number_of_Residues:
709

# Metabolic_Enzyme_29_Molecular_Weight:
80761

# Metabolic_Enzyme_29_Theoretical_pI:
9.31

# Metabolic_Enzyme_29_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_29_General_Function:
Not Available

# Metabolic_Enzyme_29_Specific_Function:
Has a high affinity for both cAMP and cGMP

# Metabolic_Enzyme_29_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_29_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_29_Pfam_Domain_Function:
PF00233:PDEase_I;
PF08499:PDEase_I_N

# Metabolic_Enzyme_29_Signals:
None

# Metabolic_Enzyme_29_Transmembrane_Regions:
None

# Metabolic_Enzyme_29_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_29_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_29_GenBank_ID_Protein:
1151111

# Metabolic_Enzyme_29_SwissProt_ID:
PDE1C_HUMAN (Q14123)

# Metabolic_Enzyme_29_swissprot_Name:
Not Available

# Metabolic_Enzyme_29_Genecard_id:
PDE1C

# Metabolic_Enzyme_29_Geneatlas_id:
PDE1C

# Metabolic_Enzyme_29_hgnc_id:
HGNC:8776

# Metabolic_Enzyme_29_PDB_ID:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_29_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_29_Gene_Sequence:
>1905 bp
ATGGAGTCGCCAACCAAGGAGATTGAAGAATTTGAGAGCAACTCTCTGAAATACCTGCAA
CCGGAACAGATCGAGAAAATCTGGCTTCGGCTCCGCGGGCTGAGGAAATATAAGAAAACG
TCCCAGAGATTACGGTCTTTGGTCAAACAATTAGAGAGAGGGGAAGCTTCAGTGGTAGAT
CTTAAGAAGAATTTGGAATATGCAGCCACAGTGCTTGAATCTGTGTATATTGATGAAACA
AGGAGACTCCTGGATACAGAGGATGAGCTCAGTGACATTCAGTCAGATGCTGTGCCTTCT
GAGGTCCGAGACTGGCTGGCCTCCACCTTCACGCGGCAGATGGGGATGATGCTCAGGAGG
AGCGACGAGAAGCCCCGGTTCAAGAGCATCGTTCACGCAGTGCAGGCTGGGATATTTGTG
GAGAGAATGTATAGACGGACATCAAACATGGTTGGACTGAGCTATCCACCAGCTGTTATT
GAGGCATTAAAGGATGTGGACAAGTGGTCCTTTGACGTCTTTTCCCTCAATGAGGCCAGT
GGGGATCATGCACTGAAATTTATTTTCTATGAACTACTCACACGTTATGATCTGATCAGC
CGTTTCAAGATCCCCATTTCTGCACTTGTCTCATTTGTGGAGGCCCTGGAAGTGGGATAC
AGCAAGCACAAAAATCCTTACCATAACTTAATGCACGCTGCCGATGTTACACAGACAGTG
CATTACCTCCTCTATAAGACAGGAGTGGCGAACTGGCTGACGGAGCTGGAGATCTTTGCT
ATAATCTTCTCAGCTGCCATCCATGACTACGAGCATACCGGAACCACCAACAATTTCCAC
ATTCAGACTCGGTCTGATCCAGCTATTCTGTATAATGACAGATCTGTACTGGAGAATCAC
CATTTAAGTGCAGCTTATCGCCTTCTGCAAGATGACGAGGAAATGAATATTTTGATTAAC
CTCTCAAAGGATGACTGGAGGGAGTTTCGAACCTTGGTAATTGAAATGGTGATGGCCACA
GATATGTCTTGTCACTTCCAACAAATCAAAGCAATGAAGACTGCTCTGCAGCAGCCAGAA
GCCATTGAAAAGCCAAAAGCCTTATCCCTTATGCTGCATACAGCAGATATTAGCCATCCA
GCAAAAGCATGGGACCTCCATCATCGCTGGACAATGTCACTCCTGGAGGAGTTCTTCAGA
CAGGGTGACAGAGAAGCAGAGCTGGGGCTGCCTTTTTCTCCTCTGTGTGACCGAAAGTCC
ACTATGGTTGCTCAGTCACAAGTAGGTTTCATTGATTTCATCGTGGAACCCACCTTCACT
GTGCTTACGGACATGACCGAGAAGATTGTGAGTCCATTAATCGATGAAACCTCTCAAACT
GGTGGGACAGGACAGAGGCGTTCGAGTTTGAATAGCATCAGCTCGTCAGATGCCAAGCGA
TCAGGTGTCAAGACCTCTGGTTCAGAGGGAAGTGCCCCGATCAACAATTCTGTCATCTCC
GTTGACTATAAGAGCTTTAAAGCTACTTGGACGGAAGTGGTGCACATCAATCGGGAGAGA
TGGAGGGCCAAGGTACCCAAAGAGGAGAAGGCCAAGAAGGAAGCAGAGGAAAAGGCTCGC
CTGGCCGCAGAGGAGCAGCAAAAGGAAATGGAAGCCAAAAGCCAGGCTGAAGAAGGCGCA
TCTGGCAAAGCTGAGAAAAAGACGTCTGGAGAAACTAAGAATCAAGTCAATGGAACACGG
GCAAACAAAAGTGACAACCCTCGTGGGAAAAATTCCAAAGCCGAGAAGTCATCAGGAGAA
CAGCAACAGAATGGTGACTTCAAAGATGGTAAAAATAAGACAGACAAGAAGGATCACTCT
AACATCGGAAATGATTCAAAGAAAACAGATGATTCACAAGAGTAA

# Metabolic_Enzyme_29_GenBank_ID_Gene:
U40371

# Metabolic_Enzyme_29_Chromosome_Location:
Not Available

# Metabolic_Enzyme_29_Locus:
Not Available

# Metabolic_Enzyme_29_SNPs:
Not Available

# Metabolic_Enzyme_29_General_References:
8557689

# Metabolic_Enzyme_29_References:
Not Available

# Metabolic_Enzyme_30_ID:
5896

# Metabolic_Enzyme_30_Name:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

# Metabolic_Enzyme_30_Synonyms:
GMP-PDE alpha; PDE V-B1

# Metabolic_Enzyme_30_Gene_Name:
PDE6A

# Metabolic_Enzyme_30_Protein_Sequence:
>Rod cGMPspecific 3',5'cyclic phosphodiesterase subunit alpha
MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFSNYHSPSSMEESEI
IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV
LEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS
PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKWYHLSYLHNCETRRGQI
LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVP
PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIM
NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM
ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW
ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE
ALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD
IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH
MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACD
LSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV
CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGN
QPGGNPSPGGATTSKSCCIQ

# Metabolic_Enzyme_30_Number_of_Residues:
860

# Metabolic_Enzyme_30_Molecular_Weight:
99636

# Metabolic_Enzyme_30_Theoretical_pI:
5.48

# Metabolic_Enzyme_30_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_30_General_Function:
Not Available

# Metabolic_Enzyme_30_Specific_Function:
This protein participates in processes of transmission and amplification of the visual signal

# Metabolic_Enzyme_30_Pathway:
Not Available

# Metabolic_Enzyme_30_Reaction:
guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate

# Metabolic_Enzyme_30_Pfam_Domain_Function:
PF01590:GAF;
PF00233:PDEase_I

# Metabolic_Enzyme_30_Signals:
None

# Metabolic_Enzyme_30_Transmembrane_Regions:
None

# Metabolic_Enzyme_30_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_30_EC_Link:
EC 3.1.4.35

# Metabolic_Enzyme_30_GenBank_ID_Protein:
2366987

# Metabolic_Enzyme_30_SwissProt_ID:
PDE6A_HUMAN (P16499)

# Metabolic_Enzyme_30_swissprot_Name:
Not Available

# Metabolic_Enzyme_30_Genecard_id:
PDE6A

# Metabolic_Enzyme_30_Geneatlas_id:
PDE6A

# Metabolic_Enzyme_30_hgnc_id:
HGNC:8785

# Metabolic_Enzyme_30_PDB_ID:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_30_Subcellular_Location:
Cell membrane; lipid-anchor; cytoplasmic side (Potential)

# Metabolic_Enzyme_30_Gene_Sequence:
>2583 bp
ATGGGCGAGGTGACAGCAGAGGAGGTGGAGAAGTTCCTGGACTCGAATATTGGCTTTGCC
AAACAGTACTACAACCTCCACTACCGGGCCAAGCTCATCTCCGACCTCCTTGGGGCCAAG
GAGGCTGCCGTGGACTTCAGCAACTACCACTCCCCGAGCAGCATGGAGGAGAGCGAAATC
ATCTTTGATCTCCTGCGGGACTTTCAGGAGAATTTACAGACAGAGAAATGCATCTTCAAT
GTCATGAAGAAGCTGTGCTTCCTCCTGCAGGCAGACCGCATGAGCCTGTTCATGTACCGG
ACCCGCAATGGCATCGCAGAGCTGGCCACCAGGCTTTTCAATGTCCACAAGGATGCTGTC
CTCGAGGACTGCCTGGTGATGCCCGACCAAGAGATCGTCTTCCCTTTGGACATGGGCATC
GTGGGCCATGTCGCACACTCTAAGAAGATTGCTAACGTCCCCAACACAGAGGAGGATGAG
CATTTCTGTGACTTTGTGGACATCCTCACAGAGTACAAGACCAAGAACATCTTGGCTTCC
CCCATAATGAATGGGAAGGATGTGGTGGCCATAATCATGGCTGTGAATAAAGTGGATGGA
TCCCACTTCACCAAGAGAGATGAAGAGATTCTTCTCAAGTACCTCAATTTTGCAAATCTA
ATCATGAAGTGGTACCACCTGAGTTACCTGCACAACTGTGAAACTCGACGTGGCCAGATA
CTGCTGTGGTCTGGGAGCAAAGTCTTTGAAGAACTTACGGACATCGAACGACAGTTCCAC
AAAGCCCTGTACACAGTCCGTGCTTTCCTCAACTGTGACAGATACTCTGTGGGTCTCTTA
GACATGACCAAGCAGAAGGAATTTTTTGATGTGTGGCCGGTTCTGATGGGTGAAGTTCCA
CCTTACTCTGGTCCCAGGACTCCGGATGGAAGAGAAATTAACTTTTACAAGGTCATTGAC
TACATCCTGCATGGCAAAGAGGACATCAAAGTCATCCCGAATCCACCTCCTGACCATTGG
GCTTTAGTAAGCGGTCTCCCCGCTTATGTTGCCCAGAATGGCCTGATTTGCAACATCATG
AACGCGCCTGCGGAGGACTTTTTTGCATTTCAGAAAGAACCTCTGGATGAGTCTGGATGG
ATGATTAAAAATGTGCTTTCAATGCCGATTGTGAACAAGAAGGAAGAAATTGTTGGAGTG
GCCACATTTTACAATCGTAAAGATGGGAAGCCCTTTGATGAAATGGATGAGACGCTCATG
GAGTCTTTGACTCAATTTCTGGGCTGGTCTGTCTTAAATCCTGACACCTATGAGTCAATG
AATAAACTTGAAAATAGGAAGGATATTTTCCAGGACATAGTAAAATATCATGTGAAGTGT
GACAATGAAGAAATTCAGAAAATCTTGAAAACCAGAGAGGTGTATGGGAAGGAGCCATGG
GAGTGTGAGGAAGAGGAGCTGGCTGAGATCCTGCAAGCGGAGCTGCCAGATGCAGATAAA
TACGAAATTAATAAATTTCACTTCAGTGACTTACCCCTAACAGAACTGGAGCTGGTAAAA
TGTGGAATACAGATGTATTATGAGCTCAAAGTGGTGGATAAATTTCACATTCCACAAGAG
GCCCTGGTGCGGTTCATGTACTCCCTGAGTAAGGGCTACCGCAAGATCACCTACCACAAC
TGGCGGCACGGCTTCAACGTGGGGCAGACCATGTTCTCCCTGCTGGTGACGGGAAAGCTG
AAGCGCTACTTCACGGACCTAGAGGCCTTGGCCATGGTCACTGCTGCTTTCTGCCATGAC
ATTGACCACAGAGGCACCAATAACCTCTACCAGATGAAATCCCAGAACCCACTGGCCAAG
CTCCATGGGTCCTCTATCTTGGAAAGACACCACTTGGAGTTTGGCAAAACACTGCTCAGA
GACGAGAGCCTGAATATCTTTCAAAACCTCAATCGTCGACAGCATGAGCATGCCATCCAC
ATGATGGACATTGCAATCATTGCCACAGACCTCGCCCTGTATTTCAAGAAGAGGACGATG
TTCCAAAAGATCGTGGATCAGTCTAAGACATATGAGAGTGAACAGGAGTGGACACAGTAC
ATGATGCTGGAGCAGACACGGAAGGAAATCGTTATGGCCATGATGATGACCGCCTGTGAT
CTCTCAGCCATCACCAAACCCTGGGAGGTGCAGAGCCAGGTAGCTCTGCTGGTGGCTGCT
GAATTCTGGGAACAAGGTGACCTGGAGCGCACGGTGCTGCAACAGAATCCCATTCCCATG
ATGGACAGAAACAAAGCAGATGAACTCCCTAAGCTTCAAGTCGGCTTCATTGACTTTGTT
TGCACCTTCGTCTACAAGGAATTCTCCCGTTTCCACGAGGAGATCACCCCAATGTTGGAC
GGGATCACCAACAATCGCAAGGAGTGGAAGGCGCTTGCTGATGAGTACGATGCCAAGATG
AAGGTGCAGGAGGAGAAGAAGCAGAAACAGCAGTCGGCCAAGTCAGCAGCCGCAGGAAAT
CAGCCGGGGGGAAACCCCAGCCCAGGGGGTGCAACTACATCCAAGTCCTGCTGCATCCAG
TAA

# Metabolic_Enzyme_30_GenBank_ID_Gene:
M26061

# Metabolic_Enzyme_30_Chromosome_Location:
Not Available

# Metabolic_Enzyme_30_Locus:
Not Available

# Metabolic_Enzyme_30_SNPs:
Not Available

# Metabolic_Enzyme_30_General_References:
2155175; 7493036

# Metabolic_Enzyme_30_References:
Not Available

# Metabolic_Enzyme_31_ID:
5984

# Metabolic_Enzyme_31_Name:
Adenylate cyclase type 1

# Metabolic_Enzyme_31_Synonyms:
Adenylate cyclase type I; ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; Ca(2+/calmodulin- activated adenylyl cyclase

# Metabolic_Enzyme_31_Gene_Name:
ADCY1

# Metabolic_Enzyme_31_Protein_Sequence:
>Adenylate cyclase type 1
MAGAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRACDEEFACPELEALFRGYTLRLEQAA
TLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQ
QVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVR
SLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVRILTERSQR
KAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHD
NVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGL
TQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWS
NDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIVPSH
RRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALR
TASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQK
YHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRV
QCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLSSGGQRTALP
TLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTSYILVLELSGYTRTGGGAV
SGRSYEPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNL
LPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEI
IADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFD
VLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQV
TEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEGRTDGNGSQIRSLGLDRKMCPFGRA
GLQGRRPPVCPMPGVSVRAGLPPHSPGQYLPSAAAGKEA

# Metabolic_Enzyme_31_Number_of_Residues:
1119

# Metabolic_Enzyme_31_Molecular_Weight:
123442

# Metabolic_Enzyme_31_Theoretical_pI:
8.49

# Metabolic_Enzyme_31_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  phosphorus-oxygen lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  cyclic nucleotide biosynthesis
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_31_General_Function:
Signal transduction mechanisms 

# Metabolic_Enzyme_31_Specific_Function:
This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning

# Metabolic_Enzyme_31_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_31_Reaction:
ATP = 3',5'-cyclic AMP + diphosphate

# Metabolic_Enzyme_31_Pfam_Domain_Function:
PF00211:Guanylate_cyc

# Metabolic_Enzyme_31_Signals:
None

# Metabolic_Enzyme_31_Transmembrane_Regions:
64-84
88-108
125-145
158-178
183-203
214-234
611-631
635-655
674-694
725-745
753-773
775-794

# Metabolic_Enzyme_31_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_31_EC_Link:
EC 4.6.1.1

# Metabolic_Enzyme_31_GenBank_ID_Protein:
41472630

# Metabolic_Enzyme_31_SwissProt_ID:
ADCY1_HUMAN (Q08828)

# Metabolic_Enzyme_31_swissprot_Name:
Not Available

# Metabolic_Enzyme_31_Genecard_id:
ADCY1

# Metabolic_Enzyme_31_Geneatlas_id:
ADCY1

# Metabolic_Enzyme_31_hgnc_id:
HGNC:232

# Metabolic_Enzyme_31_PDB_ID:
Not Available

# Metabolic_Enzyme_31_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_31_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_31_Subcellular_Location:
Membrane; multi-pass membrane protein

# Metabolic_Enzyme_31_Gene_Sequence:
>314 bp
ATGAAGGAGGACTTCCTGAAGCCCCCTGAGAGGATTTTCCACAAGATTTACATCCAGAGG
CACGACAATGTGAGCATCCTGTTTGCTGACATCGTGGGTTTCACGGGCTTGGCATCCCAG
TGCACAGCCCAGGAGCTGGTGAAACTCCTCAATGAGCTCTTCGGCAAGTTCGATGAATTA
GCCACGGAGAACCACTGTCGCCGCATCAAGATTCTCGGGGACTGCTACTACTGCGTGTCG
GGCCTCACCCAGCCCAAGACTGACCATGCCCACTGCTGTGTGGAGATGGGACTCGACATG
ATTGATACCATCAC

# Metabolic_Enzyme_31_GenBank_ID_Gene:
AC069008

# Metabolic_Enzyme_31_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_31_Locus:
7p13-p12

# Metabolic_Enzyme_31_SNPs:
rs2293106; rs2461127; rs12754; rs2280496; rs7806607; rs2280495; rs2471267; rs10249706; rs10225980; rs1128602; rs17172603; rs3735667; rs3735669; rs1042009; rs1467270; rs2461117; rs2461108; rs10951831; rs1104975; rs7810126; rs7778636; rs2461110; rs2471226; rs6463295; rs6463298; rs2471264; rs1357111; rs11766222; rs2461130; rs1521471; rs11762524; rs7793137; rs2471263; rs2960288; rs1915599; rs2037444; rs2461118; rs6975239; rs2293104; rs7778387; rs1521469; rs868362; rs870010; rs1521470; rs9639924; rs1006299; rs2461112; rs10807926; rs6463299; rs7456393; rs2471258; rs10951828; rs4529350; rs9639925; rs6977046; rs10807928; rs2471271; rs10951827; rs2280497; rs4724427; rs3735672; rs12670925; rs17172602; rs2293105; rs6961503; rs3735670; rs4724420; rs17567824; rs6961888; rs11761929; rs11982719; rs1464428; rs2471222; rs12670400; rs11762453; rs7807265; rs12702149; rs4724425; rs2461106; rs1474244; rs2471260; rs883988; rs7804996; rs1521472; rs10243170; rs2248284; rs10263580; rs11979797; rs11766192; rs871563; rs4720512; rs10241950; rs2461129; rs11770994; rs12702150; rs10268339; rs17489793; rs10807927; rs12112098; rs2471241; rs11972954; rs7792675; rs3536; rs10951823; rs2471276; rs12690837; rs4720518; rs7800818; rs2461122; rs10256378; rs6974374; rs10226873; rs11766207; rs2471261; rs9638990; rs2247685; rs2139895; rs2037445; rs2471273; rs3735673; rs6957861; rs10254640; rs11977613; rs13222078; rs7783816; rs1124990; rs13240121; rs9639926; rs12155410; rs10258603; rs12112281; rs34154333; rs2471239; rs2877339; rs11767300; rs7809900; rs7780429; rs2461131; rs3902808; rs12669591; rs2293107; rs2461124; rs9638989; rs11760377; rs13226036; rs2461121; rs11767059; rs11767872; rs12668534; rs12111599; rs10951825; rs2877351; rs13225938; rs12702161; rs7807421; rs2471257; rs6955293; rs867516; rs2247917; rs4724419; rs7801634; rs2139898; rs6958039; rs2471259; rs11984154; rs2247709; rs11972999; rs867582; rs10274298; rs2471250; rs7800510; rs9638987; rs17172592; rs7809966; rs2139896; rs2471240; rs4436025; rs11770013; rs12702162; rs12530532; rs7800525; rs10258618; rs6946621; rs2471270; rs12112588; rs2272036; rs7792861; rs6955528; rs12112953; rs2293109; rs10258881; rs10951824; rs2461123; rs10258761; rs11769970; rs6968369; rs7777413; rs7808825; rs2250129; rs34902534; rs2471268; rs3735668; rs11350985; rs2461126; rs2461128; rs5883942; rs34728351; rs2471269; rs1132637; rs35270804; rs5883943; rs34101422; rs11973107; rs3830573; rs2461114; rs4720517; rs12702148; rs28694706; rs2471275; rs35431860; rs7783828; rs34257665; rs11343827; rs11339042; rs34427131; rs35387539; rs4724421; rs2461105; rs13240621; rs2471251; rs13240113; rs34305305; rs34719678; rs7809506; rs2139897; rs35081678; rs36057382; rs4503018; rs11982319; rs35222941; rs10690012; rs36198225; rs34124080; rs34483902; rs7804581; rs2471262; rs11313310; rs5024473; rs2461109; rs6953182; rs35743607; rs6951344; rs13233855; rs2461120; rs11410895; rs13232498; rs4724423; rs13310976; rs4720515; rs5883938; rs34120282; rs28401605; rs7458556; rs34978727; rs36044061; rs7804984; rs35079206; rs7809180; rs868361; rs11981504; rs7796703; rs13225766; rs13233555; rs13226250; rs12702152; rs34930804; rs7785961; rs28577244; rs34359165; rs11771815; rs34881750; rs2461133; rs35561311; rs2471234; rs35760107; rs34295331; rs4720513; rs5883940; rs34083766; rs35406812; rs12702176; rs4308622; rs34673212; rs9942666; rs2471255; rs35435140; rs12702156; rs13240243; rs12702151; rs36032612; rs34258818; rs6977779; rs36082157; rs35976262; rs34919304; rs35877216; rs2293108; rs12113182; rs35601179; rs35477338; rs11763466; rs35005237; rs2461115; rs13226531; rs12702174; rs35109595; rs35373388; rs939622; rs4610646; rs11768954; rs3537; rs13225561; rs35860366; rs11525815; rs36198491; rs36198861; rs2461113; rs34591162; rs34611897; rs13225748; rs5883939; rs34845193; rs7795678; rs2177012; rs34754357; rs2177013; rs28605014; rs11972623; rs34358529; rs34991533; rs6975096; rs10686528; rs17172596; rs1122489; rs34732975; rs2471274; rs35105335; rs10668553; rs2471231; rs6954211; rs7809185; rs35763189; rs2471272; rs11976730; rs12666385; rs12673763; rs13226264; rs34859139; rs2461111; rs34639539; rs34971084; rs13240627; rs13225654; rs34818265; rs2461132; rs10951830; rs35012146; rs7804852; rs1879591; rs34074322; rs3215301; rs34838063; rs4436024; rs34081349; rs13231888; rs2471221; rs12702159; rs36081772; rs2461134; rs3924382; rs11763467; rs6953320; rs13240626; rs4720514; rs1829648; rs12535170; rs34748506; rs6966133; rs35143991; rs6958222; rs35907242; rs35858181; rs11523693; rs13309734; rs35901579; rs35346432; rs7807276; rs34506484; rs34522967; rs35649036; rs35804260; rs13223806; rs34588538; rs11365338; rs36053872; rs4724422; rs36092155; rs13310968; rs2471235; rs2461116; rs1879589; rs35996092; rs2461119; rs12702157; rs11444187; rs13310977; rs12702175; rs1879590; rs5883941; rs11464042; rs5021796; rs6950394; rs34705083; rs35339777; rs13240242; rs34001812; rs7809348; rs6970284; rs34948762; rs36018487; rs34278385; rs35864133; rs11974210; rs11980099; rs12538363; rs12721477; rs12721480; rs1554465; rs2461125; rs2471266; rs3185708; rs3735666; rs4724418; rs6972089; rs7357339

# Metabolic_Enzyme_31_General_References:
12853948; 8314585

# Metabolic_Enzyme_31_References:
Not Available

# Metabolic_Enzyme_32_ID:
7532

# Metabolic_Enzyme_32_Name:
Superoxide dismutase [Cu-Zn]

# Metabolic_Enzyme_32_Synonyms:
Not Available

# Metabolic_Enzyme_32_Gene_Name:
SOD1

# Metabolic_Enzyme_32_Protein_Sequence:
>Superoxide dismutase CuZn
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS
AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV
HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ

# Metabolic_Enzyme_32_Number_of_Residues:
154

# Metabolic_Enzyme_32_Molecular_Weight:
15936

# Metabolic_Enzyme_32_Theoretical_pI:
6.07

# Metabolic_Enzyme_32_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  metal ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on superoxide radicals as acceptor
Function:  superoxide dismutase activity
Function:  copper, zinc superoxide dismutase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  superoxide metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_32_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_32_Specific_Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems

# Metabolic_Enzyme_32_Pathway:
Not Available

# Metabolic_Enzyme_32_Reaction:
2 O2*- + 2 H+ = O2 + H2O2

# Metabolic_Enzyme_32_Pfam_Domain_Function:
PF00080:Sod_Cu

# Metabolic_Enzyme_32_Signals:
None

# Metabolic_Enzyme_32_Transmembrane_Regions:
None

# Metabolic_Enzyme_32_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_32_EC_Link:
EC 1.15.1.1

# Metabolic_Enzyme_32_GenBank_ID_Protein:
1237407

# Metabolic_Enzyme_32_SwissProt_ID:
SODC_HUMAN (P00441)

# Metabolic_Enzyme_32_swissprot_Name:
Not Available

# Metabolic_Enzyme_32_Genecard_id:
SOD1

# Metabolic_Enzyme_32_Geneatlas_id:
SOD1

# Metabolic_Enzyme_32_hgnc_id:
HGNC:11179

# Metabolic_Enzyme_32_PDB_ID:
1PU0

# Metabolic_Enzyme_32_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_32_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_32_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_32_Gene_Sequence:
>465 bp
ATGGCGACGAAGGCCGTGTGCGTGCTGAAGGGCGACGGCCCAGTGCAGGGCATCATCAAT
TTCGAGCAGAAGGAAAGTAATGGACCAGTGAAGGTGTGGGGAAGCATTAAAGGACTGACT
GAAGGCCTGCATGGATTCCATGTTCATGAGTTTGGAGATAATACAGCAGGCTGTACCAGT
GCAGGTCCTCACTTTAATCCTCTATCCAGAAAACACGGTGGGCCAAAGGATGAAGAGAGG
CATGTTGGAGACTTGGGCAATGTGACTGCTGACAAAGATGGTGTGGCCGATGTGTCTATT
GAAGATTCTGTGATCTCACTCTCAGGAGACCATTGCATCATTGGCCGCACACTGGTGGTC
CATGAAAAAGCAGATGACTTGGGCAAAGGTGGAAATGAAGAAAGTACAAAGACAGGAAAC
GCTGGAAGTCGTTTGGCTTGTGGTGTAATTGGGATCGCCCAATAA

# Metabolic_Enzyme_32_GenBank_ID_Gene:
L44139

# Metabolic_Enzyme_32_Chromosome_Location:
Not Available

# Metabolic_Enzyme_32_Locus:
Not Available

# Metabolic_Enzyme_32_SNPs:
rs7277748; rs17880487; rs4998557; rs10432782; rs4817420; rs1041740; rs4816405; rs17883234; rs17878802; rs2234694; rs2070424; rs16988404; rs9967983; rs6650814; rs8133032; rs17884057; rs17881296; rs4816407; rs17884464; rs17884233; rs11567845; rs17880044; rs17881180; rs17884448; rs17885219; rs3216079; rs17880490; rs17885634; rs17881732; rs17881274; rs17882503; rs11910115; rs17883296; rs1804450; rs11556620; rs1804449; rs11556619; rs1050098; rs41391245; rs15012; rs16988412; rs1804447; rs17885940; rs16988395; rs11556622; rs17881581; rs1050089; rs1804448; rs11930; rs17885303; rs17883998; rs12482567; rs17880227; rs17880318; rs17884462; rs17882986; rs17883270; rs35816372; rs7510525; rs4816406; rs17881671; rs35497195; rs17881135; rs11307260; rs17886692; rs36092510; rs17880439; rs17880208; rs17884040; rs17881807; rs17885833; rs17880326; rs17886658; rs17882967; rs10708722; rs17881051; rs17884260; rs17886025; rs17883222; rs36060566; rs17881254; rs34595699; rs11567846; rs17883733; rs35856206; rs17880795; rs17886606; rs17883461; rs35008456; rs17881415; rs36233087; rs36233089; rs34871028; rs17886051; rs34075558; rs36232791; rs36232792; rs17886748; rs36232793; rs36233091; rs17882997; rs36233086; rs17878855; rs35984269; rs34576531; rs17881711; rs36233090; rs10470162; rs11701598; rs11910269; rs12152067; rs12626475; rs16988413; rs16988427; rs202445; rs202446; rs202448; rs202449; rs202450; rs2173962; rs2833475; rs2833476; rs2833477; rs7275825; rs9305467

# Metabolic_Enzyme_32_General_References:
6770891; 3160582; 3889846; 6577438; 2853161; 7002610; 1463506; 9541385; 10329151; 9718300; 8592323; 8446170; 8332197; 8351519; 8179602; 7980516; 8069312; 7951252; 7881433; 7836951; 7997024; 7870076; 7887412; 7795609; 7655468; 7655469; 7655471; 8528216; 7700376; 7647793; 7501156; 7496169; 8682505; 8938700; 8907321; 8990014; 9101297; 9455977; 10732812; 9131652; 10400992; 10430435; 11535232; 11369193; 12402272

# Metabolic_Enzyme_32_References:
16965878

# Metabolic_Enzyme_33_ID:
5533

# Metabolic_Enzyme_33_Name:
Arginase-1

# Metabolic_Enzyme_33_Synonyms:
Type I arginase; Liver-type arginase

# Metabolic_Enzyme_33_Gene_Name:
ARG1

# Metabolic_Enzyme_33_Protein_Sequence:
>Arginase1
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK

# Metabolic_Enzyme_33_Number_of_Residues:
322

# Metabolic_Enzyme_33_Molecular_Weight:
34735

# Metabolic_Enzyme_33_Theoretical_pI:
7.25

# Metabolic_Enzyme_33_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Function:  arginase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  urea cycle intermediate metabolism
Process:  arginine metabolism
Process:  arginine catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_33_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_33_Specific_Function:
L-arginine + H(2)O = L-ornithine + urea

# Metabolic_Enzyme_33_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_33_Reaction:
L-arginine + H2O = L-ornithine + urea

# Metabolic_Enzyme_33_Pfam_Domain_Function:
PF00491:Arginase

# Metabolic_Enzyme_33_Signals:
None

# Metabolic_Enzyme_33_Transmembrane_Regions:
None

# Metabolic_Enzyme_33_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_33_EC_Link:
EC 3.5.3.1

# Metabolic_Enzyme_33_GenBank_ID_Protein:
178995

# Metabolic_Enzyme_33_SwissProt_ID:
ARGI1_HUMAN (P05089)

# Metabolic_Enzyme_33_swissprot_Name:
Not Available

# Metabolic_Enzyme_33_Genecard_id:
ARG1

# Metabolic_Enzyme_33_Geneatlas_id:
ARG1

# Metabolic_Enzyme_33_hgnc_id:
HGNC:663

# Metabolic_Enzyme_33_PDB_ID:
Not Available

# Metabolic_Enzyme_33_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_33_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_33_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_33_Gene_Sequence:
>969 bp
ATGAGCGCCAAGTCCAGAACCATAGGGATTATTGGAGCTCCTTTCTCAAAGGGACAGCCA
CGAGGAGGGGTGGAAGAAGGCCCTACAGTATTGAGAAAGGCTGGTCTGCTTGAGAAACTT
AAAGAACAAGAGTGTGATGTGAAGGATTATGGGGACCTGCCCTTTGCTGACATCCCTAAT
GACAGTCCCTTTCAAATTGTGAAGAATCCAAGGTCTGTGGGAAAAGCAAGCGAGCAGCTG
GCTGGCAAGGTGGCACAAGTCAAGAAGAACGGAAGAATCAGCCTGGTGCTGGGCGGAGAC
CACAGTTTGGCAATTGGAAGCATCTCTGGCCATGCCAGGGTCCACCCTGATCTTGGAGTC
ATCTGGGTGGATGCTCACACTGATATCAACACTCCACTGACAACCACAAGTGGAAACTTG
CATGGACAACCTGTATCTTTCCTCCTGAAGGAACTAAAAGGAAAGATTCCCGATGTGCCA
GGATTCTCCTGGGTGACTCCCTGTATATCTGCCAAGGATATTGTGTATATTGGCTTGAGA
GACGTGGACCCTGGGGAACACTACATTTTGAAAACTCTAGGCATTAAATACTTTTCAATG
ACTGAAGTGGACAGACTAGGAATTGGCAAGGTGATGGAAGAAACACTCAGCTATCTACTA
GGAAGAAAGAAAAGGCCAATTCATCTAAGTTTTGATGTTGACGGACTGGACCCATCTTTC
ACACCAGCTACTGGCACACCAGTCGTGGGAGGTCTGACATACAGAGAAGGTCTCTACATC
ACAGAAGAAATCTACAAAACAGGGCTACTCTCAGGATTAGATATAATGGAAGTGAACCCA
TCCCTGGGGAAGACACCAGAAGAAGTAACTCGAACAGTGAACACAGCAGTTGCAATAACC
TTGGCTTGTTTCGGACTTGCTCGGGAGGGTAATCACAAGCCTATTGACTACCTTAACCCA
CCTAAGTAA

# Metabolic_Enzyme_33_GenBank_ID_Gene:
M14502

# Metabolic_Enzyme_33_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_33_Locus:
6q23

# Metabolic_Enzyme_33_SNPs:
Not Available

# Metabolic_Enzyme_33_General_References:
3540966; 3174433; 14574404; 2241902; 1463019; 1598908; 7649538

# Metabolic_Enzyme_33_References:
16684608; 17064391

# Metabolic_Enzyme_34_ID:
6687

# Metabolic_Enzyme_34_Name:
Proto-oncogene tyrosine-protein kinase FGR

# Metabolic_Enzyme_34_Synonyms:
P55-FGR; C- FGR

# Metabolic_Enzyme_34_Gene_Name:
FGR

# Metabolic_Enzyme_34_Protein_Sequence:
>Protooncogene tyrosineprotein kinase 
FGRMGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFS
SQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA
RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK
GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL
IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT
MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP
QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG
SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM
PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT

# Metabolic_Enzyme_34_Number_of_Residues:
529

# Metabolic_Enzyme_34_Molecular_Weight:
59479

# Metabolic_Enzyme_34_Theoretical_pI:
5.29

# Metabolic_Enzyme_34_GO_Classification:
>>>
Function:  protein-tyrosine kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_34_General_Function:
Not Available

# Metabolic_Enzyme_34_Specific_Function:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

# Metabolic_Enzyme_34_Pathway:
Not Available

# Metabolic_Enzyme_34_Reaction:
Not Available

# Metabolic_Enzyme_34_Pfam_Domain_Function:
PF07714:Pkinase_Tyr;
PF00017:SH2;
PF00018:SH3_1

# Metabolic_Enzyme_34_Signals:
None

# Metabolic_Enzyme_34_Transmembrane_Regions:
None

# Metabolic_Enzyme_34_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_34_EC_Link:
EC 2.7.10.2

# Metabolic_Enzyme_34_GenBank_ID_Protein:
182574

# Metabolic_Enzyme_34_SwissProt_ID:
FGR_HUMAN (P09769)

# Metabolic_Enzyme_34_swissprot_Name:
Not Available

# Metabolic_Enzyme_34_Genecard_id:
FGR

# Metabolic_Enzyme_34_Geneatlas_id:
FGR

# Metabolic_Enzyme_34_hgnc_id:
HGNC:3697

# Metabolic_Enzyme_34_PDB_ID:
Not Available

# Metabolic_Enzyme_34_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_34_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_34_Subcellular_Location:
Not Available

# Metabolic_Enzyme_34_Gene_Sequence:
>1590 bp
ATGGGCTGTGTGTTCTGCAAGAAATTGGAGCCGGTGGCCACGGCCAAGGAGGATGCTGGC
CTGGAAGGGGACTTCAGAAGCTACGGGGCAGCAGACCACTATGGGCCTGACCCCACTAAG
GCCCGGCCTGCATCCTCATTTGCCCACATCCCCAACTACAGCAACTTCTCCTCTCAGGCC
ATCAACCCTGGCTTCCTTGATAGTGGCACCATCAGGGGTGTGTCAGGGATTGGGGTGACC
CTGTTCATTGCCCTGTATGACTATGAGGCTCGAACTGAGGATGACCTCACCTTCACCAAG
GGCGAGAAGTTCCACATCCTGAACAATACTGAAGGTGACTGGTGGGAGGCTCGGTCTCTC
AGCTCCGGAAAAACTGGCTGCATTCCCAGCAACTACGTGGCCCCTGTTGACTCAATCCAA
GCTGAAGAGTGGTACTTTGGAAAGATTGGGAGAAAGGATGCAGAGAGGCAGCTGCTTTCA
CCAGGCAACCCCCAGGGGGCCTTTCTCATTCGGGAAAGCGAGACCACCAAAGGTGCCTAC
TCCCTGTCCATCCGGGACTGGGATCAGACCAGAGGCGATCATGTGAAGCATTACAAGATC
CGCAAACTGGACATGGGCGGCTACTACATCACCACACGGGTTCAGTTCAACTCGGTGCAG
GAGCTGGTGCAGCACTACATGGAGGTGAATGACGGGCTGTGCAACCTGCTCATCGCGCCC
TGCACCATCATGAAGCCGCAGACGCTGGGCCTGGCCAAGGACGCCTGGGAGATCAGCCGC
AGCTCCATCACGCTGGAGCGCCGGCTGGGCACCGGCTGCTTCGGGGATGTGTGGCTGGGC
ACGTGGAACGGCAGCACTAAGGTGGCGGTGAAGACGCTGAAGCCGGGCACCATGTCCCCG
AAGGCCTTCCTGGAGGAGGCGCAGGTCATGAAGCTGCTGCGGCACGACAAGCTGGTGCAG
CTGTACGCCGTGGTGTCGGAGGAGCCCATCTACATCGTGACCGAGTTCATGTGTCACGGC
AGCTTGCTGGATTTTCTCAAGAACCCAGAGGGCCAGGATTTGAGGCTGCCCCAATTGGTG
GACATGGCAGCCCAGGTAGCTGAGGGCATGGCCTACATGGAACGCATGAACTACATTCAC
CGCGACCTGAGGGCAGCCAACATCCTGGTTGGGGAGCGGCTGGCGTGCAAGATCGCAGAC
TTTGGCTTGGCGCGTCTCATCAAGGACGATGAGTACAACCCCTGCCAAGGTTCCAAGTTC
CCCATCAAGTGGACAGCCCCAGAAGCTGCCCTCTTTGGCAGATTCACCATCAAGTCAGAC
GTGTGGTCCTTTGGGATCCTGCTCACTGAGCTCATCACCAAGGGCCGAATCCCCTACCCA
GGCATGAATAAACGGGAAGTGTTGGAACAGGTGGAGCAGGGCTACCACATGCCGTGCCCT
CCAGGCTGCCCAGCATCCCTGTACGAGGCCATGGAACAGACCTGGCGTCTGGACCCGGAG
GAGAGGCCTACCTTCGAGTACCTGCAGTCCTTCCTGGAGGACTACTTCACCTCCGCTGAA
CCACAGTACCAGCCCGGGGATCAGACATAG

# Metabolic_Enzyme_34_GenBank_ID_Gene:
M19722

# Metabolic_Enzyme_34_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_34_Locus:
1p36.2-p36.1

# Metabolic_Enzyme_34_SNPs:
rs2231877; rs2231870; rs761069; rs11800755; rs2231874; rs17162676; rs11800191; rs2231871; rs2231876; rs2231873; rs17362027; rs11802103; rs1292089; rs2231872; rs2231868; rs17162673; rs2231863; rs6598891; rs878648; rs4508035; rs34597831; rs35334091; rs2231878; rs34718693; rs2231869; rs2231867; rs2231883; rs1890463; rs2231875; rs5773194; rs35558221; rs2231881; rs12758939; rs12049219; rs12075682; rs2231879; rs35024740; rs2231882; rs33991727; rs10701577; rs12096621; rs2231880; rs2231864; rs34000614; rs35879602; rs2231865; rs10695181; rs34737291; rs2231866; rs28546507; rs11576582; rs11802278; rs11802297; rs11809483; rs12039836; rs12726763; rs1292073; rs17162665; rs1890462; rs4908343; rs545502; rs6658795; rs6677501

# Metabolic_Enzyme_34_General_References:
3275868; 2852026; 3330776; 1690869; 3023853

# Metabolic_Enzyme_34_References:
16902949; 16902952

# Metabolic_Enzyme_35_ID:
7434

# Metabolic_Enzyme_35_Name:
Caspase-3 precursor

# Metabolic_Enzyme_35_Synonyms:
CASP-3; Apopain; Cysteine protease CPP32; Yama protein; CPP-32; SREBP cleavage activity 1; SCA-1[Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]

# Metabolic_Enzyme_35_Gene_Name:
CASP3

# Metabolic_Enzyme_35_Protein_Sequence:
>Caspase3 precursor
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

# Metabolic_Enzyme_35_Number_of_Residues:
277

# Metabolic_Enzyme_35_Molecular_Weight:
31608

# Metabolic_Enzyme_35_Theoretical_pI:
6.51

# Metabolic_Enzyme_35_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  cysteine-type endopeptidase activity
Function:  caspase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_35_General_Function:
Not Available

# Metabolic_Enzyme_35_Specific_Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin

# Metabolic_Enzyme_35_Pathway:
Not Available

# Metabolic_Enzyme_35_Reaction:
Not Available

# Metabolic_Enzyme_35_Pfam_Domain_Function:
PF00656:Peptidase_C14

# Metabolic_Enzyme_35_Signals:
None

# Metabolic_Enzyme_35_Transmembrane_Regions:
None

# Metabolic_Enzyme_35_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_35_EC_Link:
EC 3.4.22.56

# Metabolic_Enzyme_35_GenBank_ID_Protein:
561666

# Metabolic_Enzyme_35_SwissProt_ID:
CASP3_HUMAN (P42574)

# Metabolic_Enzyme_35_swissprot_Name:
Not Available

# Metabolic_Enzyme_35_Genecard_id:
CASP3

# Metabolic_Enzyme_35_Geneatlas_id:
CASP3

# Metabolic_Enzyme_35_hgnc_id:
HGNC:1504

# Metabolic_Enzyme_35_PDB_ID:
1CP3

# Metabolic_Enzyme_35_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_35_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_35_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_35_Gene_Sequence:
>834 bp
ATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATC
ATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGAT
TATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGA
ATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAAC
TTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATG
CGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGC
CATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACA
AACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATT
CAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGAT
GACATGGCGTGTCATAAAATACCAGTGGATGCCGACTTCTTGTATGCATACTCCACAGCA
CCTGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGT
GCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAAC
CGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAA
CAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAA

# Metabolic_Enzyme_35_GenBank_ID_Gene:
U13737

# Metabolic_Enzyme_35_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_35_Locus:
4q34

# Metabolic_Enzyme_35_SNPs:
rs35578277; rs1049210; rs35566035; rs1049253; rs2720378; rs3087455; rs6948; rs4647640; rs4647610; rs4647617; rs4647642; rs4647634; rs4647611; rs4647620; rs1049216; rs4647641; rs4647618; rs4647609; rs4647694; rs8549; rs4647698; rs4647614; rs4647621; rs4647622; rs4647616; rs4647633; rs4647643; rs4647630; rs34184817; rs4647647; rs35422505; rs4647624; rs4647626; rs4647696; rs4647606; rs4647631; rs4647646; rs4647607; rs4647625; rs34022730; rs35439719; rs2720377; rs4647632; rs4647628; rs2310103; rs34309992; rs4647629; rs4647644; rs4647636; rs2019978; rs2705891; rs1830254; rs2720376; rs2696056; rs4241793; rs4647667; rs4647688; rs4647663; rs1405942; rs4647652; rs1405938; rs4647662; rs2705901; rs1405944; rs4647671; rs4647665; rs2696057; rs4647693; rs4647672; rs2705897; rs4647669; rs4647673; rs4647692; rs4647674; rs4647666; rs4647686; rs4647683; rs4647690; rs4647657; rs4987118; rs4647679; rs4647670; rs4987119; rs4647658; rs4647684; rs4647675; rs4647650; rs34319440; rs4647685; rs2696048; rs4647651; rs4647676; rs4647687; rs4647655; rs13128316; rs13435139; rs4647704; rs4647700; rs12646257; rs4647701; rs4647623; rs4647635; rs10028033; rs12641602; rs13101834; rs11380373; rs4647695; rs34119644; rs2705892; rs34858791; rs35063555; rs4647699; rs4647639; rs34095700; rs4647619; rs13102911; rs4647645; rs4647612; rs13101835; rs4647637; rs4647638; rs2705893; rs4647649; rs2696060; rs10028034; rs4647697; rs4647613; rs35978407; rs4647608; rs4647615; rs28418774; rs4647648; rs1802667; rs34568867; rs7442206; rs4647682; rs4647656; rs4647681; rs4647668; rs4647677; rs4647678; rs4647691; rs35261594; rs4647689; rs4647653; rs35966919; rs34740772; rs4647659; rs41314884; rs9997231; rs3215361; rs4647661; rs4647654; rs10014306; rs10660141; rs4647664; rs4647660; rs4647680; rs10034836; rs35094553; rs9715122; rs4647705; rs34083547; rs9715863; rs4647702; rs4647703; rs11930666; rs12108497; rs12507711; rs13108061; rs13435890; rs1405937; rs2696058; rs2696059; rs2705881; rs2705882; rs2705900; rs2720388; rs2720389; rs34605630; rs4647600; rs4647602; rs4647603; rs4647605; rs4861629; rs4862396; rs4862399; rs7673753; rs7674164; rs7687648; rs9685847

# Metabolic_Enzyme_35_General_References:
7983002; 7774019; 7596430; 8673606; 9045680; 10821855; 8755496; 8696339

# Metabolic_Enzyme_35_References:
16622024; 16679718; 17065410

# Macromolecular_Interacting_Partner_1_ID:
6490

# Macromolecular_Interacting_Partner_1_Name:
Tyrosine-protein kinase JAK2

# Macromolecular_Interacting_Partner_1_Synonyms:
Janus kinase 2; JAK-2

# Macromolecular_Interacting_Partner_1_Gene_Name:
JAK2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Tyrosineprotein kinase JAK2
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG
EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF
PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQF
SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC
YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA
MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
1132

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
130675

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.21

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein-tyrosine kinase activity
Function:  receptor signaling protein tyrosine kinase activity
Function:  Janus kinase activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  organelle
Component:  non-membrane-bound organelle
Component:  intracellular non-membrane-bound organelle
Component:  cytoskeleton

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Tyrosine kinase of the non-receptor type, involved in interleukin-3 and probably interleukin-23 signal transduction

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF07714:Pkinase_Tyr;
PF00017:SH2

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 2.7.10.2

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
3068752

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
JAK2_HUMAN (O60674)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
JAK2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
JAK2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6192

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Intracytoplasmic membrane; peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated (By similarity)

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>3399 bp
ATGGGAATGGCCTGCCTTACGATGACAGAAATGGAGGGAACATCCACCTCTTCTATATAT
CAGAATGGTGATATTTCTGGAAATGCCAATTCTATGAAGCAAATAGATCCAGTTCTTCAG
GTGTATCTTTACCATTCCCTTGGGAAATCTGAGGCAGATTATCTGACCTTTCCATCTGGG
GAGTATGTTGCAGAAGAAATCTGTATTGCTGCTTCTAAAGCTTGTGGTATCACACCTGTG
TATCATAATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGTATCCACCCAACCAT
GTCTTCCATATAGATGAGTCAACCAGGCATAATGTACTCTACAGAATAAGATTTTACTTT
CCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAATATCTCGAGGTGCT
GAAGCTCCTCTTCTTGATGACTTTGTCATGTCTTACCTCTTTGCTCAGTGGCGGCATGAT
TTTGTGCACGGATGGATAAAAGTACCTGTGACTCATGAAACACAGGAAGAATGTCTTGGG
ATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAACCCCACTGGCCATC
TATAACTCTATCAGCTACAAGACATTCTTACCAAAATGTATTCGAGCAAAGATCCAAGAC
TATCATATTTTGACAAGGAAGCGAATAAGGTACAGATTTCGCAGATTTATTCAGCAATTC
AGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTATAAATCTGGAAACT
CTGCAGTCTGCCTTCTACACAGAGAAATTTGAAGTAAAAGAACCTGGAAGTGGTCCTTCA
GGTGAGGAGATTTTTGCAACCATTATAATAACTGGAAACGGTGGAATTCAGTGGTCAAGA
GGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGTTATATTGCGATTTT
TCTAATATTATTGATGTCAGTATTAAGCAAGCAAACCAAGAGGGTTCAAATGAAAGCCGA
GTTGTAACTATCCATAAGCAAGATGGTAAAAATCTGGAAATTGAACTTAGCTCATTAAGG
GAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAACTGCAGATGCACAT
CATTACCTCTGTAAAGAAGTAGCACCTCCAGCCGTGCTTGAAAATATACAAAGCAACTGT
CATGGCCCAATTTCGATGGATTTTGCCATTAGTAAACTGAAGAAAGCAGGTAATCAGACT
GGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATTTTTTGACTTTTGCT
GTCGAGCGAGAAAATGTCATTGAATATAAACACTGTTTGATTACAAAAAATGAGAATGAA
GAGTACAACCTCAGTGGGACAAAGAAGAACTTCAGCAGTCTTAAAGATCTTTTGAATTGT
TACCAGATGGAAACTGTTCGCTCAGACAATATAATTTTCCAGTTTACTAAATGCTGTCCC
CCAAAGCCAAAAGATAAATCAAACCTTCTAGTCTTCAGAACGAATGGTGTTTCTGATGTA
CCAACCTCACCAACATTACAGAGGCCTACTCATATGAACCAAATGGTGTTTCACAAAATC
AGAAATGAAGATTTGATATTTAATGAAAGCCTTGGCCAAGGCACTTTTACAAAGATTTTT
AAAGGCGTACGAAGAGAAGTAGGAGACTACGGTCAACTGCATGAAACAGAAGTTCTTTTA
AAAGTTCTGGATAAAGCACACAGAAACTATTCAGAGTCTTTCTTTGAAGCAGCAAGTATG
ATGAGCAAGCTTTCTCACAAGCATTTGGTTTTAAATTATGGAGTATGTGTCTGTGGAGAC
GAGAATATTCTGGTTCAGGAGTTTGTAAAATTTGGATCACTAGATACATATCTGAAAAAG
AATAAAAATTGTATAAATATATTATGGAAACTTGAAGTTGCTAAACAGTTGGCATGGGCC
ATGCATTTTCTAGAAGAAAACACCCTTATTCATGGGAATGTATGTGCCAAAAATATTCTG
CTTATCAGAGAAGAAGACAGGAAGACAGGAAATCCTCCTTTCATCAAACTTAGTGATCCT
GGCATTAGTATTACAGTTTTGCCAAAGGACATTCTTCAGGAGAGAATACCATGGGTACCA
CCTGAATGCATTGAAAATCCTAAAAATTTAAATTTGGCAACAGACAAATGGAGTTTTGGT
ACCACTTTGTGGGAAATCTGCAGTGGAGGAGATAAACCTCTAAGTGCTCTGGATTCTCAA
AGAAAGCTACAATTTTATGAAGATAGGCATCAGCTTCCTGCACCAAAGTGGGCAGAATTA
GCAAACCTTATAAATAATTGTATGGATTATGAACCAGATTTCAGGCCTTCTTTCAGAGCC
ATCATACGAGATCTTAACAGTTTGTTTACTCCAGATTATGAACTATTAACAGAAAATGAC
ATGTTACCAAATATGAGGATAGGTGCCCTGGGGTTTTCTGGTGCCTTTGAAGACCGGGAT
CCTACACAGTTTGAAGAGAGACATTTGAAATTTCTACAGCAACTTGGCAAGGGTAATTTT
GGGAGTGTGGAGATGTGCCGGTATGACCCTCTACAGGACAACACTGGGGAGGTGGTCGCT
GTAAAAAAGCTTCAGCATAGTACTGAAGAGCACCTAAGAGACTTTGAAAGGGAAATTGAA
ATCCTGAAATCCCTACAGCATGACAACATTGTAAAGTACAAGGGAGTGTGCTACAGTGCT
GGTCGGCGTAATCTAAAATTAATTATGGAATATTTACCATATGGAAGTTTACGAGACTAT
CTTCAAAAACATAAAGAACGGATAGATCACATAAAACTTCTGCAGTACACATCTCAGATA
TGCAAGGGTATGGAGTATCTTGGTACAAAAAGGTATATCCACAGGGATCTGGCAACGAGA
AATATATTGGTGGAGAACGAGAACAGAGTTAAAATTGGAGATTTTGGGTTAACCAAAGTC
TTGCCACAAGACAAAGAATACTATAAAGTAAAAGAACCTGGTGAAAGTCCCATATTCTGG
TATGCTCCAGAATCACTGACAGAGAGCAAGTTTTCTGTGGCCTCAGATGTTTGGAGCTTT
GGAGTGGTTCTGTATGAACTTTTCACATACATTGAGAAGAGTAAAAGTCCACCAGCGGAA
TTTATGCGTATGATTGGCAATGACAAACAAGGACAGATGATCGTGTTCCATTTGATAGAA
CTTTTGAAGAATAATGGAAGATTACCAAGACCAGATGGATGCCCAGATGAGATCTATATG
ATCATGACAGAATGCTGGAACAATAATGTAAATCAACGCCCCTCCTTTAGGGATCTAGCT
CTTCGAGTGGATCAAATAAGGGATAACATGGCTGGATGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AF058925

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_1_Locus:
9p24

# Macromolecular_Interacting_Partner_1_SNPs:
rs10429491; rs2230724; rs2230728; rs1327493; rs2225125; rs7849191; rs10974914; rs1327494; rs6476934; rs7046736; rs10815147; rs7034753; rs7030260; rs10974916; rs7868130; rs11998810; rs10815143; rs10115312; rs2274471; rs10815142; rs10974913; rs4587378; rs2209773; rs2274472; rs7045000; rs7852309; rs10815144; rs12347727; rs11998868; rs7852988; rs2890618; rs10974915; rs10156475; rs7849067; rs10815146; rs12345127; rs12684418; rs7865605; rs10123873; rs12000101; rs10120763; rs7867137; rs10815145; rs7870811; rs10758670; rs7018656; rs16922523; rs16922525; rs12352214; rs11999928; rs16922518; rs10156618; rs10974900; rs7863828; rs4372063; rs10114718; rs1159782; rs2149555; rs966871; rs12005893; rs11788963; rs7857730; rs3780373; rs10974960; rs7045491; rs10974921; rs7043489; rs7851556; rs7036476; rs10815157; rs2183137; rs3780370; rs7847294; rs7870694; rs10815160; rs7028112; rs1536799; rs10121491; rs7847141; rs1410779; rs1328918; rs4495487; rs3780366; rs7869668; rs7872649; rs2149556; rs10974963; rs3780365; rs7875908; rs1536798; rs1536800; rs1328917; rs10121077; rs10815162; rs913594; rs10815154; rs10974938; rs7033052; rs11999932; rs7034878; rs10217652; rs10974939; rs3780374; rs7861599; rs7468147; rs7470337; rs3780367; rs10491652; rs6476939; rs12552828; rs7043371; rs10815152; rs10974922; rs11788834; rs11794708; rs1028912; rs7037207; rs12342421; rs10120550; rs10815148; rs11794778; rs12552825; rs7871070; rs2149557; rs10114315; rs6476938; rs11793659; rs7034539; rs12004039; rs7046077; rs17425637; rs7046511; rs7873790; rs4593605; rs6476937; rs7039518; rs2149560; rs7859390; rs3780371; rs10758672; rs10974969; rs10124627; rs11998913; rs12340866; rs10974944; rs3780375; rs3780372; rs12348771; rs12005968; rs2104685; rs7031456; rs7856825; rs12343867; rs6476936; rs1571437; rs10974947; rs10815149; rs7023146; rs12004727; rs7863219; rs2274649; rs12340895; rs7025540; rs12335546; rs6476940; rs10119004; rs10283563; rs16924516; rs7852755; rs16922647; rs10815153; rs10974933; rs7019858; rs6476935; rs7865719; rs7035030; rs16922611; rs16922602; rs9886706; rs12551254; rs16922576; rs7033053; rs41384650; rs7871190; rs16922581; rs7046366; rs7022333; rs12004861; rs10283564; rs16922648; rs10283725; rs7871704; rs9777208; rs10481522; rs7048465; rs7023796; rs3041357; rs10117459; rs10117591; rs2031904; rs9886851; rs7032785; rs10481523; rs12002357; rs2094621; rs12349785; rs9886891; rs12004723; rs7867965; rs9775719; rs7857081; rs10815151; rs12338854; rs3780377; rs12339774; rs7851969; rs1984743; rs11999076; rs3780368; rs2094620; rs12339666; rs11793886; rs1034072; rs10815150; rs10974936; rs3824432; rs11788790; rs7851455; rs12343065; rs12554699; rs2094622; rs2094392; rs7038763; rs7868821; rs7875265; rs10115172; rs9284048; rs11791507; rs16922607; rs10974935; rs6476933; rs1887429; rs3808850; rs10119356; rs1887428; rs10974946; rs17490221; rs35844880; rs41316003; rs34793603; rs3925597; rs35668020; rs10119726; rs41302214; rs10974945; rs13301717; rs10974901; rs41314565; rs13299842; rs34517443; rs35760698; rs35635409; rs10974906; rs34736970; rs35445556; rs12376611; rs34517487; rs1063935; rs7049107; rs12348255; rs12346527; rs10974907; rs7868678; rs34759722; rs10974918; rs35878130; rs10974911; rs4322058; rs28754892; rs12352123; rs35632123; rs34141875; rs34140014; rs34899364; rs7863708; rs34489944; rs34282341; rs34360761; rs12339580; rs11999506; rs7046013; rs34660349; rs4428717; rs10974910; rs7028000; rs34806254; rs10974917; rs41303235; rs12346093; rs35167433; rs4742069; rs28450816; rs7030315; rs10123976; rs7026646; rs35860358; rs41303215; rs35773400; rs4527935; rs12340582; rs10974908; rs28510269; rs12348178; rs35029508; rs34944921; rs35231187; rs10974904; rs13301718; rs12340325; rs35676824; rs12346713; rs10974912; rs10974919; rs34777294; rs34307158; rs10974905; rs10114182; rs34060288; rs7040351; rs12341983; rs7023156; rs35121907; rs5896105; rs2031906; rs10115424; rs34471452; rs10974928; rs35878951; rs10974943; rs35023014; rs28537882; rs2149559; rs34519862; rs28798372; rs10117235; rs11793772; rs10120566; rs10117565; rs10974964; rs28470704; rs10974957; rs12351277; rs10974924; rs13297052; rs12336577; rs28674503; rs35301068; rs5896106; rs10117501; rs4742066; rs28722716; rs10815161; rs34321061; rs28861154; rs12351248; rs11793775; rs12237834; rs10974966; rs12340770; rs35054047; rs16922620; rs34669103; rs35605870; rs41298194; rs10974952; rs10116560; rs35515110; rs12346143; rs12000084; rs13293089; rs34318704; rs36044846; rs11525937; rs12349918; rs1831226; rs12341237; rs7862841; rs13300399; rs34295778; rs3780369; rs10121004; rs7042879; rs7020860; rs10974959; rs11506661; rs12348159; rs2149558; rs35356229; rs1132485; rs7033766; rs10974937; rs35513006; rs35705423; rs12344629; rs34314052; rs1576271; rs35935859; rs34809822; rs7039283; rs12337134; rs10116610; rs34546853; rs12344976; rs35765457; rs10974971; rs28565962; rs10974962; rs10974942; rs16922579; rs11506660; rs10974956; rs34542894; rs35067160; rs16922589; rs11531774; rs35954011; rs13285470; rs34717484; rs10815163; rs34656245; rs35132075; rs35121985; rs13288746; rs41303645; rs12004239; rs7028574; rs12340894; rs10974941; rs12686652; rs34901657; rs10974967; rs11526366; rs10124201; rs3780376; rs12345355; rs5896107; rs10974923; rs10974970; rs10283730; rs3831163; rs34425667; rs34678790; rs10974954; rs28889911; rs10974948; rs4008443; rs12335663; rs3837256; rs35998435; rs10974955; rs2031907; rs1132493; rs35463922; rs5896108; rs12341930; rs13297560; rs10114303; rs3041355; rs35631801; rs34687095; rs35234932; rs12343374; rs13297757; rs10974920; rs2031905; rs35734873; rs12002850; rs7035316; rs34065983; rs12340135; rs41320051; rs10974968; rs16922577; rs7468959; rs35773106; rs10115518; rs35680743; rs35938242; rs34486118; rs11506663; rs10974965; rs12376304; rs10974934; rs35426771; rs10974940; rs34895942; rs34060020; rs12379170; rs7032780; rs13293328; rs7042457; rs41306104; rs34951671; rs35467162; rs35553526; rs12350156; rs11506664; rs28662982; rs33957916; rs28653681; rs28709814; rs28485746; rs34584133; rs35336961; rs10114261; rs10124001; rs10758669; rs10815164; rs11788164; rs11791876; rs12342708; rs12555131; rs1268767; rs13288929; rs13301772; rs17425819; rs1887427; rs2031752; rs2149552; rs3780378; rs3780379; rs3824433; rs4742060; rs4742061; rs7035251; rs7854968; rs7864782

# Macromolecular_Interacting_Partner_1_General_References:
9618263; 9446644; 9326218; 10531356; 10899310; 12023369

# Macromolecular_Interacting_Partner_1_References:
16684834

# Macromolecular_Interacting_Partner_2_ID:
6420

# Macromolecular_Interacting_Partner_2_Name:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

# Macromolecular_Interacting_Partner_2_Synonyms:
Brain cyclic nucleotide-gated channel 1; BCNG-1

# Macromolecular_Interacting_Partner_2_Gene_Name:
HCN1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Potassium/sodium hyperpolarizationactivated cyclic nucleotidegated channel 1
MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFK
VDGGGGGGGGGGGGEEPAGGFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAV
EKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNV
ASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVE
KGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFN
LIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIG
YGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSF
HKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANAD
PNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGE
ICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSI
LLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIAPINYPQMTTLNSTSSTTTPTSRM
RTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPVQSPLAARTFHYA
SPTASQLSLMQQQPQQQVQQSQPPQTQPQQPSPQPQTPGSSTPKNEVHKSTQALHNTNLT
REVRPFSAWQPSLPHEVSTLISRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVT
LFRQMSSGAIPPNRGVPPAPPPPAAALPRESSSVLNTDPDAEKPRFASNL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
890

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
98930

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
8.54

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  transporter activity
Function:  ion transporter activity
Function:  ion channel activity
Function:  voltage-gated ion channel activity
Function:  voltage-gated potassium channel activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  cation transport
Process:  monovalent inorganic cation transport
Process:  potassium ion transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Signal transduction mechanisms 

# Macromolecular_Interacting_Partner_2_Specific_Function:
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00027:cNMP_binding;
PF00520:Ion_trans;
PF08412:Ion_trans_N

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
147-167
174-194
220-240
249-269
301-321
345-366
372-392

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
HCN1_HUMAN (O60741)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
HCN1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
HCN1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:4845

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AC114975

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_2_Locus:
5p12

# Macromolecular_Interacting_Partner_2_SNPs:
rs1501358; rs1405918; rs1405916; rs1534391; rs2696013; rs2589179; rs1483312; rs1501361; rs2580258; rs1405917; rs9292918; rs2337483; rs6451798; rs6451795; rs6890010; rs6892594; rs12656485; rs6451810; rs1471683; rs6861150; rs7723380; rs10214369; rs7717890; rs7732970; rs12520124; rs6881805; rs1501359; rs10073636; rs1501362; rs2589162; rs1527833; rs7712920; rs1483311; rs10060015; rs7708653; rs994092; rs1384732; rs1564684; rs1483305; rs1852598; rs1501357; rs10473387; rs4532370; rs6888352; rs7709262; rs6451793; rs6892290; rs7700252; rs6863501; rs6864149; rs6865621; rs7719500; rs10805696; rs6451802; rs4613721; rs7717787; rs6874677; rs6875925; rs6451801; rs1384735; rs10044408; rs6414906; rs7722380; rs6451796; rs10941696; rs6874279; rs13354798; rs12651887; rs1483306; rs6451806; rs1483313; rs2580260; rs17293295; rs9790873; rs11959180; rs10512880; rs6451805; rs11957513; rs7704192; rs2589181; rs12519431; rs1351719; rs1392973; rs12522771; rs1483303; rs17345592; rs12659024; rs2337413; rs953783; rs6895055; rs17271569; rs6893773; rs12655983; rs6451807; rs12519313; rs16902191; rs12521855; rs7721731; rs6885653; rs11743392; rs2220083; rs12519133; rs6451797; rs6874127; rs755048; rs981782; rs6860200; rs3923055; rs1483304; rs16902186; rs1483308; rs6887225; rs1483309; rs12521899; rs16902199; rs13358718; rs2337954; rs12515470; rs2049656; rs12515077; rs16902099; rs12517615; rs11959861; rs35804423; rs12513449; rs4866976; rs4866929; rs12513467; rs10473384; rs4339358; rs10074312; rs1501365; rs6897926; rs7446182; rs13162651; rs6861183; rs2878967; rs6451804; rs4437383; rs1527831; rs7706140; rs1483310; rs7721486; rs4288123; rs2625497; rs17344557; rs10073055; rs2337412; rs6891513; rs1534392; rs13180087; rs7727890; rs10063439; rs5026524; rs10472402; rs4254921; rs16902114; rs2128762; rs10473389; rs7735655; rs4509030; rs13168931; rs2589171; rs12187475; rs1384734; rs10805697; rs2589169; rs12521714; rs10055044; rs12659740; rs11948518; rs1483307; rs10462091; rs13357371; rs12374423; rs7714845; rs11955343; rs17278764; rs16902188; rs10060119; rs7712840; rs12522039; rs1463593; rs11744621; rs1501363; rs4264951; rs6871092; rs9716143; rs17344896; rs2005147; rs2247112; rs16902098; rs11745711; rs11959605; rs11746890; rs11950931; rs10472404; rs2589170; rs10072421; rs2589163; rs10805694; rs7703700; rs11747512; rs12518923; rs4866975; rs2337414; rs7727853; rs7737105; rs1032738; rs16902086; rs10064595; rs2589173; rs11742172; rs4133429; rs16902163; rs12516996; rs11741075; rs12520413; rs1384733; rs6451794; rs10941699; rs9765113; rs2580259; rs13357691; rs1351720; rs2580262; rs2696018; rs6874479; rs13179496; rs10079739; rs9885523; rs16902122; rs12521112; rs6894152; rs1604320; rs1392971; rs2696011; rs2580257; rs2625499; rs12381259; rs2589161; rs1852593; rs7729910; rs16902160; rs9918122; rs9763648; rs10045420; rs16902213; rs1463594; rs7714006; rs16902195; rs11960278; rs16902088; rs13177363; rs16902083; rs4866789; rs16902164; rs16902112; rs34159951; rs10461759; rs6451812; rs4406141; rs6876408; rs10462092; rs7703337; rs9763399; rs12332696; rs17343612; rs13163424; rs10074468; rs9765278; rs12517449; rs7718142; rs2589174; rs2589182; rs10074084; rs7717729; rs16902197; rs6873359; rs12519016; rs10072719; rs3057697; rs2696009; rs2330703; rs6864928; rs17293302; rs2589159; rs10069510; rs13169640; rs16900206; rs10805695; rs12381267; rs6867827; rs13181010; rs10058524; rs16902084; rs12520240; rs10043792; rs10462087; rs12657229; rs2589165; rs16902100; rs10462090; rs11740651; rs7445554; rs13361609; rs10066808; rs13436341; rs35229491; rs6886544; rs6870996; rs34530531; rs7715446; rs13158440; rs7349789; rs13170147; rs34812174; rs13175193; rs13189788; rs34990648; rs2696008; rs35875760; rs11361226; rs34032094; rs36222206; rs28824810; rs13155195; rs34334688; rs17279770; rs13170143; rs16902205; rs35311396; rs10696140; rs5019812; rs35304078; rs6876061; rs6451800; rs10654224; rs35037248; rs34352563; rs36230541; rs10601970; rs6878442; rs34347557; rs34693745; rs35376459; rs13178796; rs11477610; rs12523520; rs34604759; rs7712052; rs35401643; rs35637620; rs6865265; rs16902193; rs7712907; rs35262477; rs6880506; rs35556267; rs13156397; rs28541899; rs34604835; rs13171396; rs11455247; rs34423213; rs11413203; rs36216493; rs34186662; rs34322744; rs13176244; rs34130488; rs4419601; rs957437; rs34465277; rs36119339; rs34363643; rs6878258; rs3028859; rs35465648; rs36145387; rs34434296; rs35205342; rs16902151; rs10044642; rs2878988; rs6897049; rs10644264; rs34066729; rs34007291; rs7716825; rs2580261; rs954522; rs34677544; rs35397550; rs34016747; rs34948740; rs2449573; rs13175865; rs2330704; rs34676110; rs34889142; rs34632955; rs34497944; rs35911703; rs13154409; rs3028840; rs5867705; rs2625500; rs34751562; rs4485938; rs11324015; rs10043815; rs16902081; rs35070235; rs2200202; rs4541664; rs2696012; rs11377214; rs2589177; rs34477193; rs35113951; rs36021683; rs11283021; rs35132838; rs13168326; rs10472403; rs6874579; rs28483020; rs4286687; rs35364353; rs36101815; rs13178716; rs2440671; rs34666490; rs35861145; rs5019813; rs6888366; rs34275482; rs1852597; rs10440655; rs13158995; rs34252428; rs34497938; rs36035960; rs13162289; rs13179810; rs34657289; rs2625498; rs13179937; rs7729614; rs13184104; rs13165674; rs13155196; rs6865405; rs12517531; rs34888587; rs11955757; rs10666273; rs34701165; rs35225342; rs3038439; rs28489566; rs10585263; rs28504010; rs34820246; rs6881317; rs12659738; rs16902194; rs34248343; rs35181881; rs2134045; rs34666220; rs36073195; rs36083072; rs34972534; rs34269195; rs12516348; rs13157378; rs961984; rs13356341; rs34854398; rs35949487; rs10071378; rs34139817; rs11750627; rs34300074; rs2877196; rs36164814; rs34720366; rs34801400; rs34835217; rs34645820; rs10528899; rs2589180; rs34685436; rs10058550; rs34797116; rs28620849; rs4975877; rs33922633; rs35840151; rs6865852; rs7714150; rs16902157; rs4254918; rs36218725; rs35623140; rs16902192; rs1531843; rs13161572; rs13175111; rs33918673; rs35751862; rs34964308; rs13182541; rs13184096; rs10066509; rs12186832; rs35929049; rs33999412; rs2589167; rs35015966; rs34525518; rs13174397; rs13179793; rs16902187; rs5867699; rs35717405; rs36162870; rs12517566; rs35967430; rs35995609; rs10473385; rs7706410; rs4314406; rs2625501; rs3057668; rs28856284; rs35243375; rs35349435; rs34176530; rs11960245; rs28872833; rs10556007; rs2589176; rs35116885; rs34937140; rs34973845; rs1825325; rs1392972; rs13164305; rs35729058; rs35864519; rs34981765; rs5006299; rs35030652; rs35826190; rs2220081; rs16902207; rs2696019; rs35197327; rs5867702; rs34787505; rs16902082; rs5867700; rs11408577; rs35738547; rs5867703; rs35458413; rs35130866; rs28783167; rs35781186; rs13169726; rs34214379; rs4866930; rs35068481; rs6899193; rs34784463; rs5001570; rs4502839; rs10078197; rs34239811; rs35348254; rs34807106; rs2589175; rs34189117; rs35839110; rs33915375; rs34680411; rs34373631; rs34137788; rs35381866; rs35296672; rs11310911; rs34306193; rs7723747; rs1994148; rs10079837; rs35485064; rs34712106; rs11739988; rs7446444; rs6884634; rs13157693; rs10440658; rs34786654; rs35200389; rs34519909; rs13181423; rs6872419; rs34651907; rs34930444; rs13183040; rs4554235; rs35028886; rs2696020; rs2220082; rs9764238; rs5867698; rs34686163; rs5867706; rs13176065; rs10473388; rs13175561; rs34885549; rs34789584; rs35968486; rs36142983; rs7720013; rs35840977; rs7720926; rs7444102; rs13157692; rs1006648; rs35105795; rs1351718; rs13176769; rs35319946; rs11299842; rs2625502; rs34697538; rs28830592; rs35419642; rs6872042; rs1587562; rs34966617; rs11354534; rs35925055; rs2589164; rs34413080; rs36003023; rs34976259; rs2625493; rs35370962; rs11310669; rs13189510; rs1852594; rs13169182; rs10683616; rs35241491; rs13163886; rs34861684; rs1527832; rs35087088; rs5019814; rs34074894; rs4616906; rs34406589; rs35481172; rs35841808; rs35731574; rs10462089; rs34134646; rs36072669; rs7447324; rs7729881; rs2696017; rs34249271; rs34311766; rs12654368; rs16902201; rs34148262; rs28405556; rs6886307; rs35257357; rs16902079; rs1392974; rs11402200; rs10440657; rs35549352; rs17340501; rs2696010; rs6451792; rs7734729; rs34876813; rs35653510; rs13158092; rs2580263; rs35637221; rs6881319; rs13180078; rs6890553; rs3057698; rs5867701; rs6865607; rs16902196; rs2625495; rs6859244; rs13188682; rs13164549; rs10071528; rs36056952; rs13154714; rs35276669; rs34186274; rs34675862; rs34720347; rs35723862; rs34050037; rs28822375; rs2589168; rs16902212; rs35932311; rs10074685; rs4429862; rs28674899; rs5867697; rs34586880; rs35782200; rs12189238; rs35034489; rs2625496; rs36174764; rs7701894; rs7728192; rs36093775; rs2625503; rs13183247; rs6898663; rs2589172; rs35230437; rs34086253; rs16902189; rs13165940; rs13163887; rs10636666; rs16902134; rs34217584; rs35790915; rs1905315; rs34691237; rs13180342; rs35117761; rs35429650; rs1358408; rs2696014; rs34193015; rs11279846; rs10035873; rs16902161; rs13166083; rs35997793; rs10642474; rs35945307; rs34393675; rs7737371; rs10644208; rs5867707; rs10062358; rs34778089; rs35954404; rs16902209; rs36021438; rs36225869; rs5867704; rs34704007; rs2589178; rs34355835; rs10440656; rs35977827; rs34158498; rs6414907; rs10683617; rs34741263; rs10587921; rs34635852; rs13158216; rs1501360; rs13158222; rs16902190; rs35874631; rs35970318; rs34760634; rs2920978; rs34122962; rs35450425; rs1501364; rs36063096; rs12517568; rs16902113; rs2589160; rs950973; rs10035564; rs10036065; rs10039387; rs12514615; rs12522524; rs16902068; rs2625494; rs35410237; rs6867018; rs6894273; rs7701207; rs7705968; rs7723960

# Macromolecular_Interacting_Partner_2_General_References:
9630217

# Macromolecular_Interacting_Partner_2_References:
16728450; 16870744; 16882011

# Macromolecular_Interacting_Partner_3_ID:
6941

# Macromolecular_Interacting_Partner_3_Name:
ATP-binding cassette sub-family A member 1

# Macromolecular_Interacting_Partner_3_Synonyms:
ATP-binding cassette transporter 1; ATP-binding cassette 1; ABC-1; Cholesterol efflux regulatory protein

# Macromolecular_Interacting_Partner_3_Gene_Name:
ABCA1

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>ATPbinding cassette subfamily A member 1
MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKA
MPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDT
SMKDMRKVLRTLQQIKKSSSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRADVILH
KVFLQGYQLHLTSLCNGSKSEEMIQLGDQEVSELCGLPREKLAAAERVLRSNMDILKPIL
RTLNSTSPFPSKELAEATKTLLHSLGTLAQELFSMRSWSDMRQEVMFLTNVNSSSSSTQI
YQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETFYDNSTTPYCNDLMK
NLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELS
PKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQSSNGS
VYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMELLDERKFWAGIVFTG
ITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVV
EQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIV
YEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFV
FLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFAS
LLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTW
YIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVS
IQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYIL
GKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVG
LPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQ
GRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLS
SCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDI
GHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAE
TSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVK
GWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQ
PWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAP
VPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDL
TGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDATKQMKK
HLKLAKDSSADRFLNSLGRFMTGLDTRNNVKVWFNNKGWHAISSFLNVINNAILRANLQK
GENPSHYGITAFNHPLNLTKQQLSEVAPMTTSVDVLVSICVIFAMSFVPASFVVFLIQER
VSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLAL
LLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNNIN
DILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEG
VVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKELTKI
YRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSN
IHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEK
YAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLT
SHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFG
LAFPGSVPKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNF
AKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
2261

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
254289

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.84

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_3_Specific_Function:
cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
22-42
640-660
683-703
716-736
745-765
777-797
827-847
1041-1057
1351-1371
1657-1677
1703-1723
1735-1755
1768-1788
1802-1822
1852-1872

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
9247086

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
ABCA1_HUMAN (O95477)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
ABCA1

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
ABCA1

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:29

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>6786 bp
ATGGCTTGTTGGCCTCAGCTGAGGTTGCTGCTGTGGAAGAACCTCACTTTCAGAAGAAGA
CAAACATGTCAGCTGCTGCTGGAAGTGGCCTGGCCTCTATTTATCTTCCTGATCCTGATC
TCTGTTCGGCTGAGCTACCCACCCTATGAACAACATGAATGCCATTTTCCAAATAAAGCC
ATGCCCTCTGCAGGAACACTTCCTTGGGTTCAGGGGATTATCTGTAATGCCAACAACCCC
TGTTTCCGTTACCCGACTCCTGGGGAGGCTCCCGGAGTTGTTGGAAACTTTAACAAATCC
ATTGTGGCTCGCCTGTTCTCAGATGCTCGGAGGCTTCTTTTATACAGCCAGAAAGACACC
AGCATGAAGGACATGCGCAAAGTTCTGAGAACATTACAGCAGATCAAGAAATCCAGCTCA
AACTTGAAGCTTCAAGATTTCCTGGTGGACAATGAAACCTTCTCTGGGTTCCTGTATCAC
AACCTCTCTCTCCCAAAGTCTACTGTGGACAAGATGCTGAGGGCTGATGTCATTCTCCAC
AAGGTATTTTTGCAAGGCTACCAGTTACATTTGACAAGTCTGTGCAATGGATCAAAATCA
GAAGAGATGATTCAACTTGGTGACCAAGAAGTTTCTGAGCTTTGTGGCCTACCAAGGGAG
AAACTGGCTGCAGCAGAGCGAGTACTTCGTTCCAACATGGACATCCTGAAGCCAATCCTG
AGAACACTAAACTCTACATCTCCCTTCCCGAGCAAGGAGCTGGCYGAAGCCACAAAAACA
TTGCTGCATAGTCTTGGGACTCTGGCCCAGGAGCTGTTCAGCATGAGAAGCTGGAGTGAC
ATGCGACAGGAGGTGATGTTTCTGACCAATGTGAACAGCTCCAGCTCCTCCACCCAAATC
TACCAGGCTGTGTCTCGTATTGTCTGCGGGCATCCCGAGGGAGGGGGGCTGAAGATCAAG
TCTCTCAACTGGTATGAGGACAACAACTACAAAGCCCTCTTTGGAGGCAATGGCACTGAG
GAAGATGCTGAAACCTTCTATGACAACTCTACAACTCCTTACTGCAATGATTTGATGAAG
AATTTGGAGTCTAGTCCTCTTTCCCGCATTATCTGGAAAGCTCTGAAGCCGCTGCTCGTT
GGGAAGATCCTGTATACACCTGACACTCCAGCCACAAGGCAGGTCATGGCTGAGGTGAAC
AAGACCTTCCAGGAACTGGCTGTGTTCCATGATCTGGAAGGCATGTGGGAGGAACTCAGC
CCCAAGATCTGGACCTTCATGGAGAACAGCCAAGAAATGGACCTTGTCCGGATGCTGTTG
GACAGCAGGGACAATGACCACTTTTGGGAACAGCAGTTGGATGGCTTAGATTGGACAGCC
CAAGACATCGTGGCGTTTTTGGCCAAGCACCCAGAGGATGTCCAGTCCAGTAATGGTTCT
GTGTACACCTGGAGAGAAGCTTTCAACGAGACTAACCAGGCAATCCGGACCATATCTCGC
TTCATGGAGTGTGTCAACCTGAACAAGCTAGAACCCATAGCAACAGAAGTCTGGCTCATC
AACAAGTCCATGGAGCTGCTGGATGAGAGGAAGTTCTGGGCTGGTATTGTGTTCACTGGA
ATTACTCCAGGCAGCATTGAGCTGCCCCATCATGTCAAGTACAAGATCCGAATGGACATT
GACAATGTGGAGAGGACAAATAAAATCAAGGATGGGTACTGGGACCCTGGTCCTCGAGCT
GACCCCTTTGAGGACATGCGGTACGTCTGGGGGGGCTTCGCCTACTTGCAGGATGTGGTG
GAGCAGGCAATCATCAGGGTGCTGACGGGCACCGAGAAGAAAACTGGTGTCTATATGCAA
CAGATGCCCTATCCCTGTTACGTTGATGACATCTTTCTGCGGGTGATGAGCCGGTCAATG
CCCCTCTTCATGACGCTGGCCTGGATTTACTCAGTGGCTGTGATCATCAAGGGCATCGTG
TATGAGAAGGAGGCACGGCTGAAAGAGACCATGCGGATCATGGGCCTGGACAACAGCATC
CTCTGGTTTAGCTGGTTCATTAGTAGCCTCATTCCTCTTCTTGTGAGCGCTGGCCTGCTA
GTGGTCATCCTGAAGTTAGGAAACCTGCTGCCCTACAGTGATCCCAGCGTGGTGTTTGTC
TTCCTGTCCGTGTTTGCTGTGGTGACAATCCTGCAGTGCTTCCTGATTAGCACACTCTTC
TCCAGAGCCAACCTGGCAGCAGCCTGTGGGGGCATCATCTACTTCACGCTGTACCTGCCC
TACGTCCTGTGTGTGGCATGGCAGGACTACGTGGGCTTCACACTCAAGATCTTCGCTARC
CTGCTGTCTCCTGTGGCTTTTGGGTTTGGCTGTGAGTACTTTGCCCTTTTTGAGGAGCAG
GGCATTGGAGTGCAGTGGGACAACCTGTTTGAGAGTCCTGTGGAGGAAGATGGCTTCAAT
CTCACCACTTCGGTCTCCATGATGCTGTTTGACACCTTCCTCTATGGGGTGATGACCTGG
TACATTGAGGCTGTCTTTCCAGGCCAGTACGGAATTCCCAGGCCCTGGTATTTTCCTTGC
ACCAAGTCCTACTGGTTTGGCGAGGAAAGTGATGAGAAGAGCCACCCTGGTTCCAACCAG
AAGAGAATATCAGAAATCTGCATGGAGGAGGAACCCACCCACTTGAAGCTGGGCGTGTCC
ATTCAGAACCTGGTAAAAGTCTACCGAGATGGGATGAAGGTGGCTGTCGATGGCCTGGCA
CTGAATTTTTATGAGGGCCAGATCACCTCCTTCCTGGGCCACAATGGAGCGGGGAAGACG
ACCACCATGTCAATCCTGACCGGGTTGTTCCCCCCGACCTCGGGCACCGCCTACATCCTG
GGAAAAGACATTCGCTCTGAGATGAGCACCATCCGGCAGAACCTGGGGGTCTGTCCCCAG
CATAACGTGCTGTTTGACATGCTGACTGTCGAAGAACACATCTGGTTCTATGCCCGCTTG
AAAGGGCTCTCTGAGAAGCACGTGAAGGCGGAGATGGAGCAGATGGCCCTGGATGTTGGT
TTGCCATCAAGCAAGCTGAAAAGCAAAACAAGCCAGCTGTCAGGTGGAATGCAGAGAAAG
CTATCTGTGGCCTTGGCCTTTGTCGGGGGATCTAAGGTTGTCATTCTGGATGAACCCACA
GCTGGTGTGGACCCTTACTCCCGCAGGGGAATATGGGAGCTGCTGCTGAAATACCGACAA
GGCCGCACCATTATTCTCTCTACACACCACATGGATGAAGCGGACGTCCTGGGGGACAGG
ATTGCCATCATCTCCCATGGGAAGCTGTGCTGTGTGGGCTCCTCCCTGTTTCTGAAGAAC
CAGCTGGGAACAGGCTACTACCTGACCTTGGTCAAGAAAGATGTGGAATCCTCCCTCAGT
TCCTGCAGAAACAGTAGTAGCACTGTGTCATACCTGAAAAAGGAGGACAGTGTTTCTCAG
AGCAGTTCTGATGCTGGCCTGGGCAGCGACCATGAGAGTGACACGCTGACCATCGATGTC
TCTGCTATCTCCAACCTCATCAGGAAGCATGTGTCTGAAGCCCGGCTGGTGGAAGACATA
GGGCATGAGCTGACCTATGTGCTGCCATATGAAGCTGCTAAGGAGGGAGCCTTTGTGGAA
CTCTTTCATGAGATTGATGACCGGCTCTCAGACCTGGGCATTTCTAGTTATGGCATCTCA
GAGACGACCCTGGAAGAAATATTCCTCAAGGTGGCCGAAGAGAGTGGGGTGGATGCTGAG
ACCTCAGATGGTACCTTGCCAGCAAGACGAAACAGGCGGGCCTTCGGGGACAAGCAGAGC
TGTCTTCGCCCGTTCACTGAAGATGATGCTGCTGATCCAAATGATTCTGACATAGACCCA
GAATCCAGAGAGACAGACTTGCTCAGTGGGATGGATGGCAAAGGGTCCTACCAGGTGAAA
GGCTGGAAACTTACACAGCAACAGTTTGTGGCCCTTTTGTGGAAGAGACTGCTAATTGCC
AGACGGAGTCGGAAAGGATTTTTTGCTCAGATTGTCTTGCCAGCTGTGTTTGTCTGCATT
GCCCTTGTGTTCAGCCTGATCGTGCCACCCTTTGGCAAGTACCCCAGCCTGGAACTTCAG
CCCTGGATGTACAACGAACAGTACACATTTGTCAGCAATGATGCTCCTGAGGACACGGGA
ACCCTGGAACTCTTAAACGCCCTCACCAAAGACCCTGGCTTCGGGACCCGCTGTATGGAA
GGAAACCCAATCCCAGACACGCCCTGCCAGGCAGGGGAGGAAGAGTGGACCACTGCCCCA
GTTCCCCAGACCATCATGGACCTCTTCCAGAATGGGAACTGGACAATGCAGAACCCTTCA
CCTGCATGCCAGTGTAGCAGCGACAAAATCAAGAAGATGCTGCCTGTGTGTCCCCCAGGG
GCAGGGGGGCTGCCTCCTCCACAAAGAAAACAAAACACTGCAGATATCCTTCAGGACCTG
ACAGGAAGAAACATTTCGGATTATCTGGTGAAGACGTATGTGCAGATCATAGCCAAAAGC
TTAAAGAACAAGATCTGGGTGAATGAGTTTAGGTATGGCGGCTTTTCCCTGGGTGTCAGT
AATACTCAAGCACTTCCTCCGAGTCAAGAAGTTAATGATGCCAYCAAACAAATGAAGAAA
CACCTAAAGCTGGCCAAGGACAGTTCTGCAGATCGATTTCTCAACAGCTTGGGAAGATTT
ATGACAGGACTGGACACCAGAAATAATGTCAAGGTGTGGTTCAATAACAAGGGCTGGCAT
GCAATCAGCTCTTTCCTGAATGTCATCAACAATGCCATTCTCCGGGCCAACCTGCAAAAG
GGAGAGAACCCTAGCCATTATGGAATTACTGCTTTCAATCATCCCCTGAATCTCACCAAG
CAGCAGCTCTCAGAGGTGGCTCYGATGACCACATCAGTGGATGTCCTTGTGTCCATCTGT
GTCATCTTTGCAATGTCCTTCGTCCCAGCCAGCTTTGTCGTATTCCTGATCCAGGAGCGG
GTCAGCAAAGCAAAACACCTGCAGTTCATCAGTGGAGTGAAGCCTGTCATCTACTGGCTC
TCTAATTTTGTCTGGGATATGTGCAATTACGTTGTCCCTGCCACACTGGTCATTATCATC
TTCATCTGCTTCCAGCAGAAGTCCTATGTGTCCTCCACCAATCTGCCTGTGCTAGCCCTT
CTACTTTTGCTGTATGGGTGGTCAATCACACCTCTCATGTACCCAGCCTCCTTTGTGTTC
AAGATCCCCAGCACAGCCTATGTGGTGCTCACCAGCGTGAACCTCTTCATTGGCATTAAT
GGCAGCGTGGCCACCTTTGTGCTGGAGCTGTTCACCGACAATAAGCTGAATAATATCAAT
GATATCCTGAAGTCCGTGTTCTTGATCTTCCCACATTTTTGCCTGGGACGAGGGCTCATC
GACATGGTGAAAAACCAGGCAATGGCTGATGCCCTGGAAAGGTTTGGGGAGAATCGCTTT
GTGTCACCATTATCTTGGGACTTGGTGGGACGAAACCTCTTCGCCATGGCCGTGGAAGGG
GTGGTGTTCTTCCTCATTACTGTTCTGATCCAGTACAGATTCTTCATCAGGCCCAGACCT
GTAAATGCAAAGCTATCTCCTCTGAATGATGAAGATGAAGATGTGAGGCGGGAAAGACAG
AGAATTCTTGATGGTGGAGGCCAGAATGACATCTTAGAAATCAAGGAGTTGACGAAGATA
TATAGAAGGAAGCGGAAGCCTGCTGTTGACAGGATTTGCGTGGGCATTCCTCCTGGTGAG
TGCTTTGGGCTCCTGGGAGTTAATGGGGCTGGAAAATCATCAACTTTCAAGATGTTAACA
GGAGATACCACTGTTACCAGAGGAGATGCTTTCCTTAACARAAATAGTATCTTATCAAAC
ATCCATGAAGTACATCAGAACATGGGCTACTGCCCTCAGTTTGATGCCATCACAGAGCTG
TTGACTGGGAGAGAACACGTGGAGTTCTTTGCCCTTTTGAGAGGAGTCCCAGAGAAAGAA
GTTGGCAAGGTTGGTGAGTGGGCGATTCGGAAACTGGGCCTCGTGAAGTATGGAGAAAAA
TATGCTGGTAACTATAGTGGAGGCAACAAACGCAAGCTCTCTACAGCCATGGCTTTGATC
GGCGGGCCTCCTGTGGTGTTTCTGGATGAACCCACCACAGGCATGGATCCCAAAGCCCGG
CGGTTCTTGTGGAATTGTGCCCTAAGTGTTGTCAAGGAGGGGAGATCAGTAGTGCTTACA
TCTCATAGTATGGAAGAATGTGAAGCTCTTTGCACTAGGATGGCAATCATGGTCAATGGA
AGGTTCAGGTGCCTTGGCAGTGTCCAGCATCTAAAAAATAGGTTTGGAGATGGTTATACA
ATAGTTGTACGAATAGCAGGGTCCAACCCGGACCTGAAGCCTGTCCAGGATTTCTTTGGA
CTTGCATTTCCTGGAAGTGTTCYAAAAGAGAAACACCGGAACATGCTACAATACCAGCTT
CCATCTTCATTATCTTCTCTGGCCAGGATATTCAGCATCCTCTCCCAGAGCAAAAAGCGA
CTCCACATAGAAGACTACTCTGTTTCTCAGACAACACTTGACCAAGTATTTGTGAACTTT
GCCAAGGACCAAAGTGATGATGACCACTTAAAAGACCTCTCATTACACAAAAACCAGACA
GTAGTGGACGTTGCAGTTCTCACATCTTTTCTACAGGATGAGAAAGTGAAAGAAAGCTAT
GTATGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF275948

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_3_Locus:
9q31.1

# Macromolecular_Interacting_Partner_3_SNPs:
rs2230808; rs2230806; rs4149313; rs2066718; rs33918808; rs9282541; rs35819696; rs2066715; rs9282543; rs35207495; rs7031748; rs2230805; rs35204915; rs2066716; rs34788556; rs9282546; rs34066619; rs35545593; rs9282539; rs13306077; rs2246841; rs9282538; rs13306075; rs9282537; rs41494750; rs2274873; rs2472455; rs9282547; rs34078184; rs363717; rs4149264; rs2575878; rs4149338; rs2791952; rs2487049; rs2472508; rs10512337; rs2515614; rs4149339; rs2472377; rs2740486; rs2516313; rs2487052; rs6479285; rs4149263; rs10512336; rs4149340; rs12003756; rs2437820; rs2437811; rs3905001; rs2515616; rs2777794; rs4149265; rs7872225; rs6479284; rs10991411; rs10991412; rs10820743; rs2515617; rs2575879; rs12347523; rs7035693; rs12335854; rs12347858; rs7861141; rs7049195; rs2254819; rs7857983; rs7861459; rs1800978; rs2515613; rs10820744; rs10991414; rs12344687; rs2437818; rs4742928; rs2472506; rs10991409; rs10991415; rs10991416; rs2243312; rs2437821; rs2472374; rs34165419; rs2515618; rs10991406; rs12237054; rs2487050; rs13291117; rs2437817; rs11792754; rs2777795; rs10521071; rs2575877; rs10991417; rs2575874; rs1799777; rs2515615; rs7035444; rs10512335; rs4149262; rs41474449; rs4100654; rs2515611; rs4149341; rs2472510; rs10991413; rs12343571; rs7849869; rs10512338; rs41432545; rs13284054; rs7030810; rs4742929; rs4149261; rs10991404; rs10991405; rs10820747; rs10991408; rs12350560; rs7872096; rs2472509; rs10991410; rs1175453; rs10820749; rs12336969; rs2472507; rs2254708; rs2740479; rs2740492; rs2740494; rs3858076; rs2482433; rs2740481; rs3818689; rs2472433; rs2487037; rs2472384; rs4149336; rs1883023; rs2740493; rs2575875; rs3904999; rs2777803; rs2777802; rs10115928; rs3858075; rs2791950; rs2020927; rs2740476; rs2254884; rs4149291; rs2297404; rs4149333; rs2487039; rs2777804; rs1331924; rs3904998; rs3847305; rs1999431; rs2066720; rs2472448; rs2297400; rs7024300; rs3847304; rs2297406; rs7047523; rs2777785; rs2243313; rs10121901; rs2777790; rs2482424; rs2777799; rs2777805; rs3780540; rs4149275; rs2275544; rs13292582; rs1999429; rs4149310; rs13306066; rs2020926; rs2297407; rs4149269; rs4743764; rs3029584; rs2253172; rs4742927; rs3847303; rs2482420; rs2777786; rs2472386; rs12001061; rs2472390; rs2274871; rs4149273; rs2065412; rs2249891; rs7043581; rs4149332; rs9282540; rs3758294; rs6479282; rs3831227; rs7859265; rs4149270; rs2472378; rs4743763; rs13290420; rs2740485; rs3847300; rs2275543; rs4149346; rs2740484; rs2417565; rs3780543; rs3824477; rs2297401; rs28652716; rs4149309; rs2253182; rs12003698; rs1929842; rs7025776; rs12002265; rs4149337; rs2777797; rs4149279; rs2575876; rs2472449; rs914546; rs2066717; rs2297409; rs3858074; rs2515629; rs4149281; rs2777787; rs2740499; rs2275542; rs2777784; rs914545; rs2253175; rs2482418; rs1929841; rs10820738; rs2472440; rs2000069; rs3847301; rs2253304; rs11790326; rs3904997; rs2740480; rs2777793; rs2777788; rs11789818; rs4149334; rs2297405; rs2275545; rs2777800; rs2515601; rs2487059; rs10820737; rs2066881; rs7341705; rs2515602; rs2297399; rs2740482; rs4149268; rs914544; rs2740491; rs1883025; rs2740487; rs12341993; rs3847302; rs12346461; rs4149327; rs12686004; rs11791258; rs4149331; rs2150867; rs4149267; rs4149272; rs2253174; rs4149335; rs10820736; rs2487058; rs7026408; rs2777801; rs4149302; rs1831553; rs9282545; rs2777789; rs2482421; rs2487055; rs2472381; rs3890182; rs13292026; rs7019569; rs10120087; rs2297398; rs13306069; rs2297402; rs4149290; rs2777798; rs2487065; rs41456650; rs3818688; rs7027801; rs2076731; rs10118061; rs3824478; rs12342847; rs10991389; rs4149274; rs4149323; rs2487062; rs4149326; rs9282544; rs13291863; rs2297408; rs2472437; rs4149294; rs2989944; rs4149320; rs2472438; rs12002435; rs11789603; rs2472441; rs2027403; rs7848844; rs4149301; rs7855185; rs41412244; rs1340354; rs2472434; rs2277181; rs9299383; rs7867698; rs2066882; rs4742926; rs2472383; rs4743762; rs4149329; rs1999430; rs10991390; rs4149284; rs2472436; rs2020928; rs2487057; rs4149296; rs4149271; rs2472439; rs6479283; rs2076730; rs4149299; rs12235875; rs13286991; rs10512334; rs10991386; rs4149319; rs7034361; rs12003906; rs4149324; rs1175293; rs4149321; rs4149311; rs7043081; rs9282549; rs12683676; rs1340353; rs4149297; rs2777791; rs2099544; rs7873387; rs13283515; rs2740488; rs11998937; rs4149308; rs2067484; rs12006437; rs10116972; rs10125482; rs10820732; rs3780546; rs2482434; rs4149316; rs4149303; rs12553591; rs4149289; rs3824479; rs2472435; rs13285112; rs2482422; rs3780542; rs4149295; rs3780541; rs41513444; rs9282542; rs41415046; rs4149328; rs4149283; rs4149325; rs10820733; rs41382749; rs12004453; rs12338782; rs2297403; rs4149282; rs2234885; rs4149307; rs2482419; rs2740478; rs9282548; rs3905000; rs9282550; rs2777792; rs2472450; rs3824481; rs7862756; rs7027196; rs1831554; rs2472385; rs1800977; rs2482432; rs10124728; rs2487048; rs10761085; rs2246293; rs2740483; rs12000659; rs2980083; rs2246298; rs2487046; rs2422493; rs10124755; rs2482437; rs34879708; rs13306072; rs4131108; rs28933692; rs1883024; rs2472458; rs13306068; rs28937313; rs2853578; rs13306073; rs2853574; rs2853577; rs1997618; rs41436749; rs28937314; rs34083760; rs35871586; rs34590907; rs41277767; rs41277763; rs35561837; rs34198118; rs2515609; rs11540326; rs11370908; rs12347784; rs12236519; rs11460644; rs10991377; rs12352393; rs12342233; rs10820748; rs35431611; rs34302197; rs34515440; rs12684473; rs5899625; rs11792330; rs2994375; rs1137170; rs34570900; rs12000590; rs34352903; rs35005766; rs33976424; rs2515612; rs10991402; rs2487051; rs11453300; rs10991407; rs35949087; rs13306079; rs7854775; rs4510920; rs13283308; rs36047954; rs28405388; rs34229509; rs10991418; rs11428977; rs11394015; rs12339957; rs2487053; rs13287957; rs35672247; rs36232543; rs10991403; rs11540325; rs3758297; rs35167860; rs41437944; rs28715489; rs34450679; rs35445387; rs3983640; rs35117818; rs35110205; rs2515610; rs35977928; rs34400919; rs33910960; rs12686280; rs28656304; rs2472373; rs12344527; rs13306080; rs1175456; rs2487060; rs35876406; rs35748412; rs35545100; rs3029650; rs974464; rs35267409; rs2118084; rs41422749; rs4149286; rs10991393; rs2515627; rs41277765; rs4149344; rs12341953; rs2472512; rs12351480; rs34813555; rs2472387; rs3029409; rs4742925; rs35093463; rs2472391; rs2740475; rs35139735; rs7041412; rs7020957; rs36053505; rs35204953; rs2437814; rs34538834; rs5899618; rs35185295; rs5899624; rs2020929; rs1340355; rs3215918; rs3842219; rs13306076; rs2740490; rs2791949; rs6151110; rs4149306; rs13291032; rs35792477; rs13306081; rs13286395; rs13299259; rs41419649; rs10991381; rs13285096; rs35124737; rs4149276; rs34153825; rs13296935; rs4149293; rs41335545; rs41504247; rs13285345; rs13297526; rs41426948; rs4742924; rs10991396; rs1175457; rs10661109; rs2515628; rs4149347; rs2482417; rs10991392; rs2472463; rs4149330; rs12341994; rs4149278; rs12350745; rs4149343; rs34544647; rs2487056; rs13292447; rs7027802; rs10991394; rs41513148; rs2274872; rs36122100; rs4149280; rs10583466; rs3780538; rs4149287; rs1175455; rs10991401; rs34564112; rs2777806; rs41456149; rs2515604; rs2482412; rs34004711; rs28599759; rs12348537; rs2472464; rs12340337; rs5899619; rs34171271; rs12351534; rs2482414; rs41537052; rs2791951; rs2740498; rs34203904; rs2472388; rs2472443; rs11404358; rs12335579; rs2740495; rs12004282; rs2245793; rs9409410; rs35474862; rs34239819; rs2472457; rs7040990; rs12344798; rs2472461; rs13285088; rs2482436; rs3215917; rs35028970; rs2980646; rs2282152; rs34484490; rs35840899; rs11788044; rs10114399; rs2066719; rs10583465; rs2472517; rs5007364; rs35543165; rs2515603; rs4149318; rs11433143; rs2472513; rs10991398; rs2472371; rs2777782; rs10690293; rs35016066; rs35366472; rs4149317; rs2472460; rs2472376; rs13301006; rs893058; rs7863889; rs2482435; rs4149298; rs34388261; rs7028667; rs28690796; rs34817114; rs34831628; rs11304201; rs2472470; rs3887301; rs7046079; rs13306082; rs35543524; rs34364224; rs2516322; rs1175454; rs13297344; rs11392079; rs4149304; rs2740477; rs35683917; rs3780539; rs2472389; rs10991387; rs34561897; rs13285117; rs34153967; rs3900832; rs2482413; rs13301802; rs34144130; rs7032574; rs4454344; rs35010837; rs2282153; rs13289355; rs5007365; rs4149300; rs34713310; rs13285437; rs2482415; rs4149349; rs28633842; rs35594183; rs41410048; rs41372647; rs41483745; rs2244278; rs36098089; rs34174449; rs4149315; rs4149288; rs11443334; rs34268559; rs10593949; rs13306078; rs10991383; rs36050540; rs5899622; rs2472372; rs2487063; rs10697892; rs2472445; rs12347789; rs2472514; rs2740496; rs1953011; rs10115901; rs13288250; rs7042310; rs5899621; rs13295806; rs10820735; rs36015529; rs10124686; rs10991397; rs2777783; rs34567819; rs7034035; rs34542857; rs34624257; rs35053902; rs4506285; rs41445345; rs2487061; rs2472375; rs36028500; rs4149266; rs7857007; rs4149285; rs11443333; rs2980645; rs13306067; rs10614372; rs13295662; rs2515626; rs4149314; rs2472370; rs4149345; rs12341868; rs10693809; rs35699471; rs10695751; rs41391445; rs11788803; rs34650643; rs2472442; rs10991395; rs13301674; rs4149292; rs5007363; rs13306070; rs2472454; rs10697891; rs5899617; rs34806386; rs35914252; rs11791454; rs41371845; rs2472444; rs13298930; rs35796082; rs34121951; rs28523599; rs2791948; rs35676433; rs2515625; rs11433144; rs2472382; rs2740497; rs4743761; rs1340352; rs7033623; rs2472462; rs34390877; rs13284961; rs7860348; rs3983644; rs35789429; rs10820740; rs35990533; rs10991385; rs4149348; rs12551384; rs10991391; rs4149277; rs35118541; rs34311859; rs28558214; rs28453232; rs41297205; rs34206414; rs13306074; rs35660402; rs5899623; rs2482416; rs10991388; rs3837273; rs13286494; rs2482423; rs3983647; rs33980331; rs28714441; rs2515600; rs41354653; rs35497119; rs2487064; rs12344156; rs34642413; rs41403644; rs2487047; rs1800976; rs2472380; rs16936183; rs34385550; rs3021455; rs16926146; rs34258946; rs28408753; rs16905745; rs2422492; rs34669957; rs2980082; rs33971077; rs2472379; rs4149342; rs11432680; rs7035955; rs10991420; rs13306071; rs2437815; rs10991419; rs34250431; rs10117535; rs10820730; rs12553329; rs2043664; rs2437819; rs2472474; rs2472482; rs2472483; rs2472485; rs2472486; rs2472487; rs2472488; rs2472489; rs2472490; rs2472495; rs2472496; rs2482429; rs2482430; rs2487038; rs2487042; rs2487054; rs2487718; rs2515606; rs2515608; rs28587567; rs2994376; rs3887137; rs4742923; rs4743765; rs7866586

# Macromolecular_Interacting_Partner_3_General_References:
10884428; 11352567; 10092505; 10431238; 12196520; 11279031; 12032171; 12763760; 10533863; 10431236; 10431237; 11086027; 10706591; 10938021; 11257260; 11257261; 11476961; 11476965; 11238261; 12204794; 12009425; 11785958; 12966036

# Macromolecular_Interacting_Partner_3_References:
16680030; 16687660

# Macromolecular_Interacting_Partner_4_ID:
7197

# Macromolecular_Interacting_Partner_4_Name:
Corticotropin-lipotropin precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
Pro-opiomelanocortin; POMC[Contains: NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin]

# Macromolecular_Interacting_Partner_4_Gene_Name:
POMC

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Corticotropinlipotropin precursor
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
267

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
29424

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Beta-endorphin and Met-enkephalin are endogenous opiates

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00976:ACTH_domain;
PF08384:NPP;
PF08035:Op_neuropeptide

# Macromolecular_Interacting_Partner_4_Signals:
1-26

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
190188

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
COLI_HUMAN (P01189)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
POMC

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
POMC

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:9201

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>789 bp
TGCAGCCGCTCGGGGGCCCTGTTGCTGGCCTTGCTGCTTCAGGCCTCCATGGAAGTGCGT
GGCTGGTGCCTGGAGAGCAGCCAGTGTCAGGACCTCACCACGGAAAGCAACCTGCTGGAG
TGCATCCGGGCCTGCAAGCCCGACCTCTCGGCCGAGACTCCCATGTTCCCGGGAAATGGC
GACGAGCAGCCTCTGACCGAGAACCCCCGGAAGTACGTCATGGGCCACTTCCGCTGGGAC
CGATTCGGCCGCCGCAACAGCAGCAGCAGCGGCAGCAGCGGCGCAGGGCAGAAGCGCGAG
GACGTCTCAGCGGGCGAAGACTGCGGCCCGCTGCCTGAGGGCGGCCCCGAGCCCCGCAGC
GATGGTGCCAAGCCGGGCCCGCGCGAGGGCAAGCGCTCCTACTCCATGGAGCACTTCCGC
TGGGGCAAGCCGGTGGGCAAGAAGCGGCGCCCAGTGAAGGTGTACCCTAACGGCGCCGAG
GACGAGTCGGCCGAGGCCTTCCCCCTGGAGTTCAAGAGGGAGCTGACTGGCCAGCGACTC
CGGGAGGGAGATGGCCCCGACGGCCCTGCCGATGACGGCGCAGGGGCCCAGGCCGACCTG
GAGCACAGCCTGCTGGTGGCGGCCGAGAAGAAGGACGAGGGCCCCTACAGGATGGAGCAC
TTCCGCTGGGGCAGCCCGCCCAAGGACAAGCGCTACGGCGGTTTCATGACCTCCGAGAAG
AGCCAGACGCCCCTGGTGACGCTGTTCAAAAACGCCATCATCAAGAACGCCTACAAGAAG
GGCGAGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
M38297

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_4_Locus:
2p23.3

# Macromolecular_Interacting_Partner_4_SNPs:
rs28932472; rs8192606; rs28932471; rs35254395; rs8192605; rs28930368; rs2071345; rs34650613; rs1042571; rs11679531; rs6713532; rs7565877; rs6713396; rs12473543; rs6756695; rs6545975; rs6756566; rs28932474; rs28932476; rs28932475; rs28932473; rs10654394; rs28932470; rs3039380; rs35411223; rs35023083; rs33950052; rs7591899; rs15461; rs2071344; rs13388660; rs9973478; rs11353932; rs13404336; rs7565427; rs34619618; rs8192607; rs35639116; rs34526166; rs10188864; rs10195561; rs11892647; rs12472851; rs13418937; rs17046887; rs17046891; rs1866146; rs2071343; rs2118404; rs2164808; rs3769671; rs3795955; rs3820935; rs6545976; rs6719226; rs6734859; rs7589318; rs7605927; rs934778

# Macromolecular_Interacting_Partner_4_General_References:
6274691; 6299668; 6314261; 3606677; 6254047; 6945581; 6267033; 6272808; 4352834; 4334191; 4338630; 4347148; 1264228; 195688; 2424570; 2839146; 7828531; 9768693; 10193875; 11244459

# Macromolecular_Interacting_Partner_4_References:
16675846; 16845490; 16869285; 17082810

# Macromolecular_Interacting_Partner_5_ID:
7193

# Macromolecular_Interacting_Partner_5_Name:
Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide

# Macromolecular_Interacting_Partner_5_Synonyms:
GRPP; Oxyntomodulin; OXY; OXM; Glucagon; Glucagon-like peptide 1; GLP-1; Glucagon-like peptide 1(7-37; GLP-1(7-37; Glucagon-like peptide 1(7-36; GLP-1(7-36; Glucagon-like peptide 2; GLP-2]

# Macromolecular_Interacting_Partner_5_Gene_Name:
GCG

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Glucagon precursor Contains: Glicentin; Glicentinrelated polypeptide
MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTS
DYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFI
AWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMNTILDNLAARDFINWLIQTKITDRK


# Macromolecular_Interacting_Partner_5_Number_of_Residues:
180

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
20909

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.14

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00123:Hormone_2

# Macromolecular_Interacting_Partner_5_Signals:
1-20

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
183270

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
GLUC_HUMAN (P01275)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
GCG

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
GCG

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:4191

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>543 bp
ATGAAAAGCATTTACTTTGTGGCTGGGTTATTTGTAATGCTGGTACAAGGCAGCTGGCAA
CGTTCCCTTCAAGACACAGAGGAGAAATCCAGATCATTCTCAGCTTCCCAGGCAGACCCA
CTCAGTGATCCTGATCAGATGAACGAGGACAAGCGCCATTCACAGGGCACATTCACCAGT
GACTACAGCAAGTATCTGGACTCCAGGCGTGCCCAAGATTTTGTGCAGTGGTTGATGAAT
ACCAAGAGGAACAGGAATAACATTGCCAAACGTCACGATGAATTTGAGAGACATGCTGAA
GGGACCTTTACCAGTGATGTAAGTTCTTATTTGGAAGGCCAAGCTGCCAAGGAATTCATT
GCTTGGCTGGTGAAAGGCCGAGGAAGGCGAGATTTCCCAGAAGAGGTCGCCATTGTTGAA
GAACTTGGCCGCAGACATGCTGATGGTTCTTTCTCTGATGAGATGAACACCATTCTTGAT
AATCTTGCCGCCAGGGACTTTATAAACTGGTTGATTCAGACCAAAATCACTGACAGGAAA
TAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
J04040

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_5_Locus:
2q36-q37

# Macromolecular_Interacting_Partner_5_SNPs:
rs5645; rs4664448; rs6732914; rs4664449; rs10490424; rs10164435; rs11897425; rs7581952; rs7569992; rs7559086; rs5649; rs4664447; rs5653; rs6727317; rs13306377; rs5647; rs5654; rs13306376; rs1990761; rs6717659; rs13001107; rs16846320; rs13416088; rs35424779; rs6717263; rs3811540; rs6717609; rs35328019; rs5650; rs11552334; rs35920035; rs11552338; rs1042405; rs11552330; rs11552335; rs34074912; rs11552339; rs17711059; rs11552332; rs16846334; rs11552331; rs11552336; rs35185096; rs35902561; rs35301560; rs10557377; rs10603613; rs5648; rs34801095; rs10671204; rs33949193; rs5652; rs5646; rs11378120; rs7569999; rs34405490; rs5651; rs11898004; rs35323923; rs13429709; rs10696486; rs34204135; rs35205044; rs3811539; rs7590067; rs11692314; rs17762054; rs41368446; rs34932341; rs10170813; rs10189636; rs11888030; rs13010545; rs13028221; rs2111487; rs2193494; rs2216338; rs2389680; rs2389681; rs3761656; rs4664450; rs6704722; rs6733736; rs7599142

# Macromolecular_Interacting_Partner_5_General_References:
2901414; 3725587; 6877358; 2753890; 8482423; 14557443; 14632334; 9287128; 12651102; 12554744; 12626323; 10605628; 9667960; 11943215; 12627948

# Macromolecular_Interacting_Partner_5_References:
16643859; 16837018; 16906154; 16916948

# Macromolecular_Interacting_Partner_6_ID:
7549

# Macromolecular_Interacting_Partner_6_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_6_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_6_Gene_Name:
INS

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_6_Signals:
1-24

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
INS

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_6_Locus:
11p15.5

# Macromolecular_Interacting_Partner_6_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_6_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_6_References:
16613879; 16731532; 16856843; 16870611

# Macromolecular_Interacting_Partner_7_ID:
7551

# Macromolecular_Interacting_Partner_7_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_7_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_7_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_7_Locus:
6p21.3

# Macromolecular_Interacting_Partner_7_SNPs:
Not Available

# Macromolecular_Interacting_Partner_7_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_7_References:
16632117; 16644475; 16751174; 16807266

# Macromolecular_Interacting_Partner_8_ID:
7559

# Macromolecular_Interacting_Partner_8_Name:
Estrogen receptor

# Macromolecular_Interacting_Partner_8_Synonyms:
ER; Estradiol receptor; ER-alpha

# Macromolecular_Interacting_Partner_8_Gene_Name:
ESR1

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Estrogen receptor
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
595

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
66217

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
8.14

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  steroid binding
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF02159:Oest_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_8_Signals:
None

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
31620888

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
ESR1_HUMAN (P03372)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
ESR1

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
ESR1

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:3467

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>63 bp
ATGCGCTGCGTCGCCTCTAACCTCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTC
TGA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
X03635

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_8_Locus:
6q25.1

# Macromolecular_Interacting_Partner_8_SNPs:
Not Available

# Macromolecular_Interacting_Partner_8_General_References:
3753802; 3754034; 8600466; 14574404; 10619354; 7916651; 7476978; 7539106; 1577818; 7838153; 9627117; 10428798; 10567404; 10359819; 11113208; 11971969; 12415108; 2247153; 8221895; 9338790; 9600906; 9875847; 9619507; 2792078; 8961262; 9195227

# Macromolecular_Interacting_Partner_8_References:
16675452; 17016431; 17030788

# Macromolecular_Interacting_Partner_9_ID:
6449

# Macromolecular_Interacting_Partner_9_Name:
RAF proto-oncogene serine/threonine-protein kinase

# Macromolecular_Interacting_Partner_9_Synonyms:
Raf- 1; C-RAF; cRaf

# Macromolecular_Interacting_Partner_9_Gene_Name:
RAF1

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>RAF protooncogene serine/threonineprotein kinase
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
648

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
73052

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
9.62

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  protein serine/threonine kinase activity
Function:  signal transducer activity
Function:  receptor signaling protein activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from apoptosis mediated by STK3

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00130:C1_1;
PF00069:Pkinase;
PF02196:RBD

# Macromolecular_Interacting_Partner_9_Signals:
None

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
EC 2.7.11.1

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
35842

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
RAF1_HUMAN (P04049)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
RAF1

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
RAF1

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:9829

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>1947 bp
ATGGAGCACATACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCC
GTGTTTGATGGCTCCAGCTGCATCTCTCCTACAATAGTTCAGCAGTTTGGCTATCAGCGC
CGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTGTT
TTCTTGCCGAACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGAC
TGCCTTATGAAAGCACTCAAGGTGAGGGGCCTGCAACCAGAGTGCTGTGCAGTGTTCAGA
CTTCTCCACGAACACAAAGGTAAAAAAGCACGCTTAGATTGGAATACTGATGCTGCGTCT
TTGATTGGAGAAGAACTTCAAGTAGATTTCCTGGATCATGTTCCCCTCACAACACACAAC
TTTGCTCGGAAGACGTTCCTGAAGCTTGCCTTCTGTGACATCTGTCAGAAATTCCTGCTC
AATGGATTTCGATGTCAGACTTGTGGCTACAAATTTCATGAGCACTGTAGCACCAAAGTA
CCTACTATGTGTGTGGACTGGAGTAACATCAGACAACTCTTATTGTTTCCAAATTCCACT
ATTGGTGATAGTGGAGTCCCAGCACTACCTTCTTTGACTATGCGTCGTATGCGAGAGTCT
GTTTCCAGGATGCCTGTTAGTTCTCAGCACAGATATTCTACACCTCACGCCTTCACCTTT
AACACCTCCAGTCCCTCATCTGAAGGTTCCCTCTCCCAGAGGCAGAGGTCGACATCCACA
CCTAATGTCCACATGGTCAGCACCACGCTGCCTGTGGACAGCAGGATGATTGAGGATGCA
ATTCGAAGTCACAGCGAATCAGCCTCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTG
AGCCCAACAGGCTGGTCACAGCCGAAAACCCCCGTGCCAGCACAAAGAGAGCGGGCACCA
GTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTAT
TATTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTT
GGAACTGTTTATAAGGGTAAATGGCACGGAGATGTTGCAGTAAAGATCCTAAAGGTTGTC
GACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACA
CGGCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTG
ACCCAGTGGTGCGAGGGCAGCAGCCTCTACAAACACCTGCATGTCCAGGAGACCAAGTTT
CAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCAT
GCAAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTA
ACAGTGAAAATTGGAGATTTTGGTTTGGCAACAGTAAAGTCACGCTGGAGTGGTTCTCAG
CAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAG
GATAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAA
CTGATGACGGGGGAGCTTCCTTATTCTCACATCAACAACCGAGATCAGATCATCTTCATG
GTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCA
ATGAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCC
CAGATCCTGTCTTCCATTGAGCTGCTCCAACACTCTCTACCGAAGATCAACCGGAGCGCT
TCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACC
ACGTCCCCGAGGCTGCCTGTCTTCTAG

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
X03484

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_9_Locus:
3p25

# Macromolecular_Interacting_Partner_9_SNPs:
rs3730297; rs3730296; rs5746182; rs12634077; rs7636754; rs6766666; rs5746173; rs6442322; rs9817675; rs11128607; rs6795441; rs6792773; rs9842787; rs2348199; rs11708716; rs1391868; rs4684871; rs12497398; rs3729926; rs12487981; rs6778959; rs11128609; rs11923427; rs2881852; rs11710163; rs11711419; rs2055312; rs11709504; rs5746162; rs7643321; rs11705805; rs17037057; rs11128608; rs2348197; rs7621562; rs5746177; rs17037075; rs17037056; rs13069461; rs5746246; rs2229757; rs1051208; rs6442321; rs9819831; rs5746160; rs5746169; rs2036230; rs6784168; rs7637392; rs7610956; rs12485257; rs5746180; rs6788838; rs5746170; rs9849807; rs5746184; rs5746157; rs9862218; rs2348198; rs9871419; rs6442320; rs13090672; rs11713601; rs4684868; rs9875104; rs4684109; rs12629082; rs9819832; rs13099808; rs13060691; rs5746168; rs2881850; rs9799212; rs6784435; rs1874942; rs963959; rs2596831; rs2055311; rs2596830; rs2454437; rs3730269; rs6777175; rs3729931; rs1039244; rs2290162; rs904452; rs1532533; rs2442807; rs2290160; rs4684864; rs2290159; rs5746207; rs5746214; rs3730268; rs5746229; rs2290161; rs1963609; rs11711270; rs3773345; rs5746235; rs5746217; rs3730275; rs6771385; rs4684867; rs963163; rs2442812; rs2648367; rs2454456; rs3773352; rs9809947; rs6442319; rs904464; rs5746223; rs5746194; rs2596828; rs5746187; rs9809501; rs2442808; rs6764324; rs5746199; rs5746193; rs2442809; rs5746200; rs2246390; rs13083303; rs5746211; rs5746236; rs3773354; rs5746225; rs2454438; rs5746215; rs3773349; rs7648489; rs4684866; rs5746208; rs5746228; rs5746234; rs17037024; rs9874380; rs5746227; rs5746192; rs1532534; rs5746205; rs5746240; rs3729927; rs11921865; rs17771249; rs17037008; rs9852128; rs4684865; rs5746226; rs3214791; rs5746188; rs17037004; rs5746195; rs5746196; rs5746191; rs5746202; rs4234511; rs5746238; rs2016492; rs5746243; rs5746206; rs2454436; rs3773353; rs5746237; rs7637824; rs7627517; rs11128606; rs5746212; rs5746209; rs4234512; rs7633300; rs9861271; rs13069726; rs3730271; rs3729929; rs11549992; rs3730273; rs5746220; rs11549993; rs5746244; rs5746219; rs1063664; rs11549991; rs34440484; rs9809842; rs3884298; rs11414306; rs35253175; rs12489489; rs1566363; rs2881851; rs11290255; rs36086937; rs13076484; rs5746158; rs5746165; rs11340532; rs9809226; rs5746176; rs36098034; rs9874216; rs9864781; rs5746181; rs7634604; rs9858147; rs2221105; rs34692000; rs11721115; rs13101202; rs36107147; rs9837418; rs35430089; rs5746161; rs34870609; rs11425554; rs35092632; rs10617036; rs34698797; rs28633721; rs34352871; rs5746171; rs10662056; rs10590595; rs4684870; rs34435807; rs35539372; rs5746179; rs11918965; rs34576938; rs5746174; rs34122637; rs13067063; rs34396520; rs35936651; rs5746175; rs5746159; rs5746167; rs35322613; rs13094393; rs11928312; rs35888373; rs11391718; rs6784943; rs34977965; rs9823187; rs2201911; rs13066872; rs36019705; rs9856899; rs35266327; rs34960021; rs13097767; rs34467117; rs9816615; rs35131384; rs5746163; rs34585793; rs35420763; rs6788570; rs5746178; rs35503570; rs13067900; rs35322564; rs11303866; rs5846780; rs9758339; rs11927709; rs34704636; rs10575568; rs13086363; rs3929415; rs13074828; rs11924289; rs11401342; rs28462331; rs11315063; rs35974000; rs3730299; rs35001118; rs11293990; rs5746156; rs11342511; rs10533439; rs13069889; rs11328513; rs34420595; rs11298876; rs4684869; rs35750419; rs34692250; rs6793346; rs34851423; rs36148013; rs35207611; rs5746164; rs35380724; rs6784448; rs7374437; rs10620481; rs5746183; rs7645487; rs4333068; rs35821519; rs10660149; rs7647328; rs10644785; rs9852359; rs5846781; rs5746172; rs35109478; rs11288044; rs3730298; rs28444243; rs35311552; rs35837104; rs13100956; rs35970309; rs6763461; rs35679453; rs34226033; rs36224409; rs34276404; rs11417525; rs35135272; rs2454439; rs5746245; rs10575214; rs2454458; rs1186459; rs11327129; rs41293391; rs5746198; rs5746242; rs5746218; rs7627610; rs6786546; rs1982997; rs5746222; rs34950151; rs5746185; rs13060685; rs34879153; rs5746204; rs5746232; rs10709590; rs5746186; rs5746221; rs2454457; rs5746201; rs5746241; rs11720565; rs35093125; rs35204864; rs34227857; rs36027311; rs1969044; rs7615794; rs10582176; rs5746210; rs35863865; rs34012468; rs36021583; rs5746224; rs11300070; rs5746189; rs5746197; rs35936024; rs35845377; rs5746239; rs11356302; rs34385763; rs11424491; rs35183993; rs11368882; rs7626030; rs5746233; rs11327130; rs11327132; rs13073921; rs10622176; rs5746216; rs34541887; rs11285578; rs35310824; rs34809492; rs12632253; rs35929766; rs1065669; rs3730270; rs1184997; rs7637931; rs2454440; rs11285580; rs34838050; rs4993021; rs5746213; rs5746231; rs34990666; rs6779366; rs5846778; rs7627543; rs12488152; rs2442811; rs6796025; rs11285579; rs36017067; rs9868981; rs11327131; rs2442810; rs5746190; rs5746203; rs6792334; rs7627544; rs4035059; rs35282213; rs7637833; rs9810597; rs35189562; rs35551917; rs13095437; rs5746230; rs11359901; rs7635795; rs35771097; rs35902148; rs5846779; rs34267109; rs13070228; rs9860631; rs13097235; rs9823121; rs34640369; rs34759664; rs1051674; rs1063610; rs12808; rs13106; rs1542848; rs15997; rs1961633; rs2344825; rs2348200; rs2442804; rs2442805; rs2596825; rs2648309; rs3192264; rs34020239; rs34924942; rs3773341; rs3806661; rs3821611; rs4684863; rs5746154; rs5746249; rs5746250; rs5746251; rs5746253; rs5746255; rs5746256; rs5746259; rs6788780; rs6793916; rs713178; rs7617041; rs7956; rs904453; rs9849171; rs9855183

# Macromolecular_Interacting_Partner_9_General_References:
3003687; 8349614; 9823899; 11784866; 7791872; 8756332; 7766599; 8710867

# Macromolecular_Interacting_Partner_9_References:
17018604; 17031853

# Macromolecular_Interacting_Partner_10_ID:
6332

# Macromolecular_Interacting_Partner_10_Name:
Cytochrome P450 17A1

# Macromolecular_Interacting_Partner_10_Synonyms:
CYPXVII; P450-C17; P450c17; Steroid 17-alpha-monooxygenase; Steroid 17-alpha-hydroxylase/17,20 lyase

# Macromolecular_Interacting_Partner_10_Gene_Name:
CYP17A1

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Cytochrome P450 17A1
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGT
KTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGA
HWQLHRRLAMATFALFKDGDQ
KLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNV
ISLICFNTSYKNGDPELNVIQNYNEGIIDNLS
KDSLVDLVPWLKIFPNKTLEKLKSHVK
IRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGP
DQDSELLSDNHILTTI
GDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRL
LLLEA
TIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPE
RFLNP
AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLP
SLEGIPKVVFLIDSFK
VKIKVRQAWREAQAEGST

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
508

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
57371

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
8.87

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_10_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Macromolecular_Interacting_Partner_10_Specific_Function:
Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty

# Macromolecular_Interacting_Partner_10_Pathway:
map00140  C21-Steroid hormone metabolism

# Macromolecular_Interacting_Partner_10_Reaction:
a steroid + AH2 + O2 = a 17alpha-hydroxysteroid + A + H2O

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00067:p450

# Macromolecular_Interacting_Partner_10_Signals:
1-24

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
EC 1.14.99.9

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
181342

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
CP17A_HUMAN (P05093)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
CYP17A1

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
CYP17A1

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:2593

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>1527 bp

ATGTGGGAGCTCGTGGCTCTCTTGCTGCTTACCCTAGCTTATTTGTTTTGGCCCAAGAG
AAGGTGCCCTG
GTGCCAAGTACCCCAAGAGCCTCCTGTCCCTGCCCCTGGTGGGCAGCC
TGCCATTCCTCCCCAGACATGG
CCATATGCATAACAACTTCTTCAAGCTGCAGAAAAAA
TATGGCCCCATCTATTCTGTTCGTATGGGCACC
AAGACTACAGTGATTGTCGGCCACCA
CCAGCTGGCCAAGGAGGTGCTTATTAAGAAGGGCAAGGACTTCT
CTGGGCGGCCTCAAA
TGGCAACTCTAGACATCGCGTCCAACAACCGTAAGGGTATCGCCTTCGCTGACTC
TGGC
GCACACTGGCAGCTGCATCGAAGGCTGGCGATGGCCACCTTTGCCCTGTTCAAGGATGGC
GATCAG
AAGCTGGAGAAGATCATTTGTCAGGAAATCAGTACATTGTGTGATATGCTGGC
CACCCACAACGGACAGT
CCATAGACATCTCCTTTCCTGTCTTCGTGGCGGTAACCAATG
TCATCTCCTTGATCTGCTTCAATACCTC
CTACAAGAATGGGGACCCTGAGTTGAATGTC
ATACAGAATTACAATGAAGGCATCATAGACAACCTGAGC
AAAGACAGCCTGGTGGACCT
AGTCCCCTGGTTGAAGATTTTCCCCAACAAAACCCTGGAAAAATTAAAGA
GCCATGTTA
AAATACGAAATGATCTGCTGAATAAAATACTTGAAAATTACAAGGAGAAATTCCGGAGTG
A
CTCTATCACCAACATGCTGGACACACTGATGCAAGCCAAGATGAACTCAGATAATGGC
AATGCTGGCCCA
GATCAAGATTCAGAGCTGCTTTCAGATAACCACATTCTCACCACCAT
AGGGGACATCTTTGGGGCTGGCG
TGGAGACCACCACCTCTGTGGTTAAATGGACCCTGG
CCTTCCTGCTGCACAATCCTCAGGTGAAGAAGAA
GCTCTACGAGGAGATTGACCAGAAT
GTGGGTTTCAGCCGCACACCAACTATCAGTGACCGTAACCGTCTC
CTCCTGCTGGAGGC
CACCATCCGAGAGGTGCTTCGCCTCAGGCCCGTGGCCCCTATGCTCATCCCCCACA
AGG
CCAACGTTGACTCCAGCATCGGTGAGTTTGCTGTGGACAAGGGCACAGAAGTTATCATCA
ATCTGTG
GGCGCTGCATCACAATGAGAAGGAGTGGCACCAGCCGGATCAGTTCATGCCT
GAGCGTTTCTTGAATCCA
GCGGGGACCCAGCTCATCTCACCGTCAGTAAGCTATTTGCC
CTTCGGAGCAGGACCTCGCTCCTGTATAG
GTGAGATCCTGGCCCGCCAGGAGCTCTTCC
TCATCATGGCCTGGCTGCTGCAGAGGTTCGACCTGGAGGT
GCCAGATGATGGGCAGCTG
CCCTCCCTGGAAGGCATCCCCAAGGTGGTCTTTCTGATCGACTCTTTCAAA
GTGAAGAT
CAAGGTGCGCCAGGCCTGGAGGGAAGCCCAGGCTGAGGGTAGCACCTAA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
M14564

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_10_Locus:
10q24.3

# Macromolecular_Interacting_Partner_10_SNPs:
rs762563; rs6163; rs6162; rs1042386; rs6164; rs743572; rs10883783; rs4919687; rs3781286; rs10786712; rs3781287; rs743575; rs1004467; rs4919686; rs17115100; rs3824755; rs284847; rs755443; rs17115104; rs3740397; rs284849; rs3020724; rs12254149; rs17855149; rs3211406; rs17115125; rs3020717; rs34343941; rs3020712; rs34132012; rs3020723; rs35403742; rs3020714; rs3020715; rs34431726; rs284848; rs3020719; rs3020721; rs284850; rs34983874; rs35538238; rs35144627; rs34713150; rs35165247; rs2911432; rs7922856; rs12219555; rs35745115; rs3020718; rs35115800; rs34846786; rs2911431; rs11191413; rs3020711; rs3020720; rs34485280; rs34620611; rs3020713; rs3020722; rs11191412; rs3890077; rs11191411; rs12775422; rs11191410; rs34005085; rs10509762; rs10883782; rs11191406; rs11191416; rs12242445; rs17115144; rs17115149; rs2486758; rs4919682; rs4919683; rs4919685; rs619824; rs7082755; rs7089422

# Macromolecular_Interacting_Partner_10_General_References:
3025870; 3500022; 3274893; 1964490; 2843762; 10406467; 2808364; 1714904; 1515452; 1740503; 8396144; 8245018; 8345056; 8027220; 8550762; 10720067; 11549685; 11836339; 12466376

# Macromolecular_Interacting_Partner_10_References:
16981135; 17121866; 17138841

# Macromolecular_Interacting_Partner_11_ID:
5998

# Macromolecular_Interacting_Partner_11_Name:
Cytochrome P450 11A1, mitochondrial precursor

# Macromolecular_Interacting_Partner_11_Synonyms:
CYPXIA1; P450(scc; Cholesterol side-chain cleavage enzyme; Cholesterol desmolase

# Macromolecular_Interacting_Partner_11_Gene_Name:
CYP11A1

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Cytochrome P450 11A1, mitochondrial precursor
MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWL
NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPER
FLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVS
VLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQM
FHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRG
ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR
HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIY
ALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML
ENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
521

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
60103

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
9.18

# Macromolecular_Interacting_Partner_11_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_11_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Macromolecular_Interacting_Partner_11_Specific_Function:
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone

# Macromolecular_Interacting_Partner_11_Pathway:
map00140  C21-Steroid hormone metabolism

# Macromolecular_Interacting_Partner_11_Reaction:
cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Signals:
None

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
EC 1.14.15.6

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
181376

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
CP11A_HUMAN (P05108)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
CYP11A1

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
CYP11A1

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:2590

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Mitochondrion

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>1566 bp
ATGCTGGCCAAGGGTCTTCCCCCACGCTCAGTCCTGGTCAAAGGCTACCAGACCTTTCTG
AGTGCCCCCAGGGAGGGGCTGGGGCGTCTCAGGGTGCCCACTGGCGAGGGAGCTGGCATC
TCCACCCGCAGTCCTCGCCCCTTCAATGAGATCCCCTCTCCTGGTGACAATGGCTGGCTA
AACCTGTACCATTTCTGGAGGGAGACGGGCACACACAAAGTCCACCTTCACCATGTCCAG
AATTTCCAGAAGTATGGCCCGATTTACAGGGAGAAGCTCGGCAACGTGGAGTCGGTTTAT
GTCATCGACCCTGAAGATGTGGCCCTTCTCTTTAAGTCCGAGGGCCCCAACCCAGAACGA
TTCCTCATCCCGCCCTGGGTCGCCTATCACCAGTATTACCAGAGACCCATAGGAGTCCTG
TTGAAGAAGTCGGCAGCCTGGAAGAAAGACCGGGTGGCCCTGAACCAGGAGGTGATGGCT
CCAGAGGCCACCAAGAACTTTTTGCCCCTGTTGGATGCAGTGTCTCGGGACTTCGTCAGT
GTCCTGCACAGGCGCATCAAGAAGGCGGGCTCCGGAAATTACTCGGGGGACATCAGTGAT
GACCTGTTCCGCTTTGCCTTTGAGTCCATCACTAACGTCATTTTTGGGGAGCGCCAGGGG
ATGCTGGAGGAAGTAGTGAACCCCGAGGCCCAGCGATTCATTGATGCCATCTACCAGATG
TTCCACACCAGCGTCCCCATGCTCAACCTTCCCCCAGACCTGTTCCGTCTGTTCAGGACC
AAGACCTGGAAGGACCATGTGGCTGCATGGGACGTGATTTTCAGTAAAGCTGACATATAC
ACCCAGAACTTCTACTGGGAATTGAGACAGAAAGGAAGTGTTCACCACGATTACCGTGGC
ATGCTCTACAGACTCCTGGGAGACAGCAAGATGTCCTTCGAGGACATCAAGGCCAACGTC
ACAGAGATGCTGGCAGGAGGGGTGGACACGACGTCCATGACCCTGCAGTGGCACTTGTAT
GAGATGGCACGCAACCTGAAGGTGCAGGATATGCTGCGGGCAGAGGTCTTGGCTGCGCGG
CACCAGGCCCAGGGAGACATGGCCACGATGCTACAGCTGGTCCCCCTCCTCAAAGCCAGC
ATCAAGGAGACACTAAGACTTCACCCCATCTCCGTGACCCTGCAGAGATATCTTGTAAAT
GACTTGGTTCTTCGAGATTACATGATTCCTGCCAAGACACTGGTGCAAGTGGCCATCTAT
GCTCTGGGCCGAGAGCCCACCTTCTTCTTCGACCCGGAAAATTTTGACCCAACCCGATGG
CTGAGCAAAGACAAGAACATCACCTACTTCCGGAACTTGGGCTTTGGCTGGGGTGTGCGG
CAGTGTCTGGGACGGCGGATCGCTGAGCTAGAGATGACCATCTTCCTCATCAATATGCTG
GAGAACTTCAGAGTTGAAATCCAACACCTCAGCGATGTGGGCACCACATTCAACCTCATT
CTGATGCCTGAAAAGCCCATCTCCTTCACCTTCTGGCCCTTTAACCAGGAAGCAACCCAG
CAGTGA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
M14565

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:15

# Macromolecular_Interacting_Partner_11_Locus:
15q23-q24

# Macromolecular_Interacting_Partner_11_SNPs:
rs6161; rs6160; rs4986873; rs2279357; rs1484215; rs11632698; rs11638442; rs12916123; rs4886594; rs1843090; rs6495096; rs41548820; rs7175214; rs2930299; rs41563614; rs41553712; rs17515476; rs12898858; rs12917295; rs2959021; rs41553612; rs41556119; rs7173655; rs7181332; rs900798; rs2073475; rs4887139; rs1049968; rs1130843; rs11544450; rs1130841; rs1132670; rs35048801; rs28671731; rs41543514; rs35153064; rs7177102; rs34371865; rs41556118; rs4887138; rs34304260; rs41543216; rs2930307; rs35856463; rs41546519; rs28681535; rs34637683; rs12442401; rs11350546; rs4640133; rs2959020; rs41550215; rs34223131; rs10635828; rs36133203; rs10644492; rs10645960; rs3831490; rs34886193; rs17522870; rs11633031; rs11635047; rs12438594; rs12899286; rs12899703; rs12900028; rs12917557; rs1564782; rs16968477; rs16968478; rs2170875; rs2277601; rs2277602; rs2277603; rs2277604; rs2277605; rs2277606; rs2279356; rs2930305; rs2930306; rs2959002; rs2959003; rs2959004; rs3803463; rs3825944; rs4077581; rs4077582; rs4077583; rs4077584; rs4077585; rs4278698; rs4432229; rs4886595; rs4887136; rs4887137; rs7163952; rs7164328; rs7174179; rs8031424; rs8034118; rs8039957; rs900802; rs9806234

# Macromolecular_Interacting_Partner_11_General_References:
3024157; 3038854; 1849407; 2419119; 10391209; 11502818; 12161514

# Macromolecular_Interacting_Partner_11_References:
16684834; 16943367

# Macromolecular_Interacting_Partner_12_ID:
7569

# Macromolecular_Interacting_Partner_12_Name:
Interleukin-6 precursor

# Macromolecular_Interacting_Partner_12_Synonyms:
IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF

# Macromolecular_Interacting_Partner_12_Gene_Name:
IL6

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Interleukin6 precursor
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYI
LDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLL
EFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQ
AQNQWLQDMTTHLILRSFKEFLQSSLRALRQM

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
212

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
23718

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
6.52

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interleukin-6 receptor binding
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
IL-6 is a cytokine with a wide variety of biological functions:it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF00489:IL6

# Macromolecular_Interacting_Partner_12_Signals:
1-29

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
32674

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
IL6_HUMAN (P05231)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
IL6

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
IL6

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:6018

# Macromolecular_Interacting_Partner_12_PDB_ID:
2IL6

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>639 bp
ATGAACTCCTTCTCCACAAGCGCCTTCGGTCCAGTTGCCTTCTCCCTGGGGCTGCTCCTG
GTGTTGCCTGCTGCCTTCCCTGCCCCAGTACCCCCAGGAGAAGATTCCAAAGATGTAGCC
GCCCCACACAGACAGCCACTCACCTCTTCAGAACGAATTGACAAACAAATTCGGTACATC
CTCGACGGCATCTCAGCCCTGAGAAAGGAGACATGTAACAAGAGTAACATGTGTGAAAGC
AGCAAAGAGGCACTGGCAGAAAACAACCTGAACCTTCCAAAGATGGCTGAAAAAGATGGA
TGCTTCCAATCTGGATTCAATGAGGAGACTTGCCTGGTGAAAATCATCACTGGTCTTTTG
GAGTTTGAGGTATACCTAGAGTACCTCCAGAACAGATTTGAGAGTAGTGAGGAACAAGCC
AGAGCTGTCCAGATGAGTACAAAAGTCCTGATCCAGTTCCTGCAGAAAAAGGCAAAGAAT
CTAGATGCAATAACCACCCCTGACCCAACCACAAATGCCAGCCTGCTGACGAAGCTGCAG
GCACAGAACCAGTGGCTGCAGGACATGACAACTCATCTCATTCTGCGCAGCTTTAAGGAG
TTCCTGCAGTCCAGCCTGAGGGCTCTTCGGCAAATGTAG

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
X04430

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_12_Locus:
7p21

# Macromolecular_Interacting_Partner_12_SNPs:
rs2069860; rs13306435; rs2069830; rs2069849; rs2069850; rs2069851; rs13306436; rs2069857; rs3087226; rs1474347; rs2069833; rs2069832; rs1554606; rs2069842; rs1548216; rs2069840; rs2066992; rs1474348; rs2069835; rs2069831; rs2069845; rs2069838; rs2069834; rs2069837; rs1524107; rs2069841; rs3087232; rs13306433; rs34277345; rs2069847; rs3087227; rs2069848; rs35361244; rs34249410; rs3087228; rs3087233; rs3087230; rs2069843; rs3087229; rs2069844; rs3087231; rs2069858; rs1800795; rs2069824; rs1800797; rs7802308; rs1800796; rs7802307; rs2069829; rs3087223; rs2069827; rs2069825; rs3087225; rs2069861; rs36215814; rs2234683; rs2069828; rs11544633; rs41477054; rs13306438; rs3915892; rs3915893; rs2069839; rs13306434; rs3087234; rs2069846; rs2069836; rs3087235; rs2069859; rs13447445; rs36215459; rs36215820; rs35081782; rs35178191; rs13447446; rs2069826; rs34328912; rs3087224; rs36215821; rs4335044; rs36215822; rs11973115; rs36215817; rs11445458; rs34224237; rs36215461; rs36215818; rs34280821; rs34012176; rs34709428; rs10242595; rs10499563; rs11766273; rs12700386; rs12700390; rs13438415; rs1546762; rs1546763; rs17147230; rs1880241; rs1880242; rs1880243; rs2069852; rs2069853; rs2069854; rs2069855; rs2069862; rs3087221; rs3087238; rs35610689; rs4398801; rs4719713; rs4719714; rs6461662; rs6946908; rs6963444; rs6963591; rs7458109; rs7784987; rs7801617; rs7805828; rs940367

# Macromolecular_Interacting_Partner_12_General_References:
3491322; 3500852; 3538015; 3023045; 3320204; 2789513; 3758081; 3266463; 1291290; 3279116; 2610854; 1883960; 7851440; 2472117; 2037043; 8555185; 9159484; 9118960

# Macromolecular_Interacting_Partner_12_References:
16777977; 16835395; 16914720; 16946718

# Macromolecular_Interacting_Partner_13_ID:
7572

# Macromolecular_Interacting_Partner_13_Name:
Transcription factor AP-1

# Macromolecular_Interacting_Partner_13_Synonyms:
Activator protein 1; AP1; Proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; p39

# Macromolecular_Interacting_Partner_13_Gene_Name:
JUN

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Transcription factor AP1
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
331

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
35676

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
9.11

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
Function:  transcription factor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF00170:bZIP_1;
PF03957:Jun

# Macromolecular_Interacting_Partner_13_Signals:
None

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
386839

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
JUN_HUMAN (P05412)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
JUN

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
JUN

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:6204

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>996 bp
ATGACTGCAAAGATGGAAACGACCTTCTATGACGATGCCCTCAACGCCTCGTTCCTCCCG
TCCGAGAGCGGACCTTATGGCTACAGTAACCCCAAGATCCTGAAACAGAGCATGACCCTG
AACCTGGCCGACCCAGTGGGGAGCCTGAAGCCGCACCTCCGCGCCAAGAACTCGGACCTC
CTCACCTCGCCCGACGTGGGGCTGCTCAAGCTGGCGTCGCCCGAGCTGGAGCGCCTGATA
ATCCAGTCCAGCAACGGGCACATCACCACCACGCCGACCCCCACCCAGTTCCTGTGCCCC
AAGAACGTGACAGATGAGCAGGAGGGGTTCGCCGAGGGCTTCGTGCGCGCCCTGGCCGAA
CTGCACAGCCAGAACACGCTGCCCAGCGTCACGTCGGCGGCGCAGCCGGTCAACGGGGCA
GGCATGGTGGCTCCCGCGGTAGCCTCGGTGGCAGGGGGCAGCGGCAGCGGCGGCTTCAGC
GCCAGCCTGCACAGCGAGCCGCCGGTCTACGCAAACCTCAGCAACTTCAACCCAGGCGCG
CTGAGCAGCGGCGGCGGGGCGCCCTCCTACGGCGCGGCCGGCCTGGCCTTTCCCGCGCAA
CCCCAGCAGCAGCAGCAGCCGCCGCACCACCTGCCCCAGCAGATGCCCGTGCAGCACCCG
CGGCTGCAGGCCCTGAAGGAGGAGCCTCAGACAGTGCCCGAGATGCCCGGCGAGACACCG
CCCCTGTCCCCCATCGACATGGAGTCCCAGGAGCGGATCAAGGCGGAGAGGAAGCGCATG
AGGAACCGCATCGCTGCCTCCAAGTGCCGAAAAAGGAAGCTGGAGAGAATCGCCCGGCTG
GAGGAAAAAGTGAAAACCTTGAAAGCTCAGAACTCGGAGCTGGCGTCCACGGCCAACATG
CTCAGGGAACAGGTGGCACAGCTTAAACAGAAAGTCATGAACCACGTTAACAGTGGGTGC
CAACTCATGCTAACGCAGCAGTTGCAAACATTTTGA

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
J04111

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_13_Locus:
1p32-p31

# Macromolecular_Interacting_Partner_13_SNPs:
rs11688; rs4647014; rs1923942; rs4647018; rs4647007; rs3748814; rs2811894; rs4647008; rs4647013; rs4647009; rs4647010; rs12816; rs9282771; rs2760499; rs4647011; rs2760501; rs1323288; rs997768; rs4646999; rs4647000; rs1980700; rs4646998; rs4647001; rs4647002; rs4647019; rs1323287; rs17265089; rs4647003; rs4647021; rs4647024; rs4647023; rs4647022; rs9989; rs2654; rs35852390; rs4647015; rs4647006; rs3833546; rs11550970; rs4647016; rs2655; rs12040370; rs4647017; rs4647012; rs1407816; rs4647020; rs4646997; rs2760500; rs4647004; rs11357804; rs4647005; rs35456681; rs2760498; rs35354070; rs10157302; rs10158603; rs11207306; rs1575440; rs2093659; rs2104259; rs2476309; rs2476310; rs2760494; rs2760495; rs2760496; rs2811888; rs2984914; rs2984915; rs33989940; rs35354349; rs4912379; rs7547523

# Macromolecular_Interacting_Partner_13_General_References:
3194415; 2825349; 8663478; 8837781; 10196196; 7816143; 8662824

# Macromolecular_Interacting_Partner_13_References:
16834536; 16869889; 16887909; 16959941

# Macromolecular_Interacting_Partner_14_ID:
7577

# Macromolecular_Interacting_Partner_14_Name:
Calcitonin gene-related peptide 1 precursor

# Macromolecular_Interacting_Partner_14_Synonyms:
Calcitonin gene-related peptide I; CGRP-I; Alpha-type CGRP

# Macromolecular_Interacting_Partner_14_Gene_Name:
CALCA

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>Calcitonin generelated peptide 1 precursor
MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQ
MKASELEQEQEREGSRIIAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFG
RRRRDLQA

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
128

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
13899

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
9.40

# Macromolecular_Interacting_Partner_14_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_14_General_Function:
Not Available

# Macromolecular_Interacting_Partner_14_Specific_Function:
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP

# Macromolecular_Interacting_Partner_14_Pathway:
Not Available

# Macromolecular_Interacting_Partner_14_Reaction:
Not Available

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF00214:Calc_CGRP_IAPP

# Macromolecular_Interacting_Partner_14_Signals:
1-25

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
179828

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
CALCA_HUMAN (P06881)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
CALCA

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
CALCA

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:1437

# Macromolecular_Interacting_Partner_14_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>387 bp
ATGGGCTTCCAAAAGTTCTCCCCCTTCCTGGCTCTCAGCATCTTGGTCCTGTTGCAGGCA
GGCAGCCTCCATGCAGCACCATTCAGGTCTGCCCTGGAGAGCAGCCCAGCAGACCCGGCC
ACGCTCAGTGAGGACGAAGCGCGCCTCCTGCTGGCTGCACTGGTGCAGGACTATGTGCAG
ATGAAGGCCAGTGAGCTGGAGCAGGAGCAAGAGAGAGAGGGCTCCAGAATCATTGCCCAG
AAGAGAGCCTGTGACACTGCCACCTGTGTGACTCATCGGCTGGCAGGCTTGCTGAGCAGA
TCAGGGGGTGTGGTGAAGAACAACTTTGTGCCCACCAATGTGGGTTCCAAAGCCTTTGGC
AGGCGCCGCAGGGACCTTCAAGCCTGA

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
M12667

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_14_Locus:
11p15.2-p15.1

# Macromolecular_Interacting_Partner_14_SNPs:
rs13306224; rs5241; rs5239; rs5240; rs5242; rs2956; rs7110615; rs5237; rs5243; rs2644690; rs35815751; rs5238; rs11607133; rs34901084; rs7925191; rs34294892; rs35212698; rs35909067; rs34815547; rs35731970; rs3758761; rs11023401; rs3781719; rs3781718; rs1553005; rs35365543; rs924099; rs11826691; rs11023400; rs34414857; rs34164367; rs34587547; rs34670162; rs2644689; rs35709504; rs35425520; rs7124346; rs2644687; rs34896084; rs35943755; rs35096144; rs2644688; rs13306223; rs2856867; rs34200140; rs35996804; rs35356387; rs34603621; rs34488736; rs35780811; rs2856866; rs1010042; rs12576047; rs34252928; rs2071411; rs7114837; rs34692826; rs7128563; rs28420578; rs12361439; rs34468174; rs13306225; rs11821926; rs1908683; rs34166188; rs35006116; rs35676062; rs35096190; rs12800646; rs35955129; rs35481990; rs28494031; rs34691228; rs12800297; rs12225355; rs12800139; rs34596504; rs1027425; rs1027426; rs1027427; rs10832338; rs11023403; rs11608134; rs11821055; rs11825513; rs11827349; rs1496163; rs1496166; rs16930769; rs16930770; rs16930784; rs17503142; rs763363; rs7929159; rs7948017; rs903808

# Macromolecular_Interacting_Partner_14_General_References:
3872459; 2571128; 6148938; 2408883; 6610687; 3034287; 6609312; 3492492; 1318039; 1988044; 2039456

# Macromolecular_Interacting_Partner_14_References:
16702994; 16816919; 16873605

# Macromolecular_Interacting_Partner_15_ID:
7010

# Macromolecular_Interacting_Partner_15_Name:
Proactivator polypeptide precursor [Contains: Saposin A

# Macromolecular_Interacting_Partner_15_Synonyms:
Protein A; Saposin B-Val; Saposin B; Sphingolipid activator protein 1; SAP-1; Cerebroside sulfate activator; CSAct; Dispersin; Sulfatide/GM1 activator; Saposin C; Co-beta-glucosidase; A1 activator; Glucosylceramidase activator; Sphingolipid activator protein 2; SAP-2; Saposin D; Protein C; Component C]

# Macromolecular_Interacting_Partner_15_Gene_Name:
PSAP

# Macromolecular_Interacting_Partner_15_Protein_Sequence:
>Proactivator polypeptide precursor Contains: Saposin 
AMYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVK
SLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILD
IIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLL
YPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMAD
ICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELV
EPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQE
VVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYL
DRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKI
GACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN

# Macromolecular_Interacting_Partner_15_Number_of_Residues:
524

# Macromolecular_Interacting_Partner_15_Molecular_Weight:
58113

# Macromolecular_Interacting_Partner_15_Theoretical_pI:
4.82

# Macromolecular_Interacting_Partner_15_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  sphingolipid metabolism
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  vacuole
Component:  lytic vacuole
Component:  lysosome

# Macromolecular_Interacting_Partner_15_General_Function:
Not Available

# Macromolecular_Interacting_Partner_15_Specific_Function:
Saposin D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12)

# Macromolecular_Interacting_Partner_15_Pathway:
Not Available

# Macromolecular_Interacting_Partner_15_Reaction:
Not Available

# Macromolecular_Interacting_Partner_15_Pfam_Domain_Function:
PF02199:SapA;
PF05184:SapB_1;
PF03489:SapB_2

# Macromolecular_Interacting_Partner_15_Signals:
1-16

# Macromolecular_Interacting_Partner_15_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_15_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_15_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_15_GenBank_ID_Protein:
220064

# Macromolecular_Interacting_Partner_15_SwissProt_ID:
SAP_HUMAN (P07602)

# Macromolecular_Interacting_Partner_15_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_15_Genecard_id:
PSAP

# Macromolecular_Interacting_Partner_15_Geneatlas_id:
PSAP

# Macromolecular_Interacting_Partner_15_hgnc_id:
HGNC:9498

# Macromolecular_Interacting_Partner_15_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_15_Subcellular_Location:
Lysosome

# Macromolecular_Interacting_Partner_15_Gene_Sequence:
>1584 bp
ATGTACGCCCTCTTCCTCCTGGCCAGCCTCCTGGGCGCGGCTCTAGCCGGCCCGGTCCTT
GGACTGAAAGAATGCACCAGGGGCTCGGCAGTGTGGTGCCAGAATGTGAAGACGGCGTCC
GACTGCGGGGCAGTGAAGCACTGCCTGCAGACCGTTTGGAACAAGCCAACAGTGAAATCC
CTTCCCTGCGACATATGCAAAGACGTTGTCACCGCAGCTGGTGATATGCTGAAGGACAAT
GCCACTGAGGAGGAGATCCTTGTTTACTTGGAGAAGACCTGTGACTGGCTTCCGAAACCG
AACATGTCTGCTTCATGCAAGGAGATAGTGGACTCCTACCTCCCTGTCATCCTGGACATC
ATTAAAGGAGAAATGAGCCGTCCTGGGGAGGTGTGCTCTGCTCTCAACCTCTGCGAGTCT
CTCCAGAAGCACCTAGCAGAGCTGAATCACCAGAAGCAGCTGGAGTCCAATAAGATCCCA
GAGCTGGACATGACTGAGGTGGTGGCCCCCTTCATGGCCAACATCCCTCTCCTCCTCTAC
CCTCAGGACGGCCCCCGCAGCAAGCCCCAGCCAAAGGATAATGGGGACGTTTGCCAGGAC
TGCATTCAGATGGTGACTGACATCCAGACTGCTGTACGGACCAACTCCACCTTTGTCCAG
GCCTTGGTGGAACATGTCAAGGAGGAGTGTGACCGCCTGGGCCCTGGCATGGCCGACATA
TGCAAGAACTATATCAGCCAGTATTCTGAAATTGCTATCCAGATGATGATGCACATGCAG
GATCAGCAACCCAAGGAGATCTGTGCGCTGGTTGGGTTCTGTGATGAGGTGAAAGAGATG
CCCATGCAGACTCTGGTCCCCGCCAAAGTGGCCTCCAAGAATGTCATCCCTGCCCTGGAA
CTGGTGGAGCCCATTAAGAAGCACGAGGTCCCAGCAAAGTCTGATGTTTACTGTGAGGTG
TGTGAATTCCTGGTGAAGGAGGTGACCAAGCTGATTGACAACAACAAGACTGAGAAAGAA
ATACTCGACGCTTTTGACAAAATGTGCTCGAAGCTGCCGAAGTCCCTGTCGGAAGAGTGC
CAGGAGGTGGTGGACACGTACGGCAGCTCCATCCTGTCCATCCTGCTGGAGGAGGTCAGC
CCTGAGCTGGTGTGCAGCATGCTGCACCTCTGCTCTGGCACGCGGCTGCCTGCACTGACC
GTTCACGTGACTCAGCCAAAGGACGGTGGCTTCTGCGAAGTGTGCAAGAAGCTGGTGGGT
TATTTGGATCGCAACCTGGAGAAAAACAGCACCAAGCAGGAGATCCTGGCTGCTCTTGAG
AAAGGCTGCAGCTTCCTGCCAGACCCTTACCAGAAGCAGTGTGATCAGTTTGTGGCAGAG
TACGAGCCCGTGCTGATCGAGATCCTGGTGGAGGTGATGGATCCTTCCTTCGTGTGCTTG
AAAATTGGAGCCTGCCCCTCGGCCCATAAGCCCTTGTTGGGAACTGAGAAGTGTATATGG
GGCCCAAGCTACTGGTGCCAGAACACAGAGACAGCAGCCCAGTGCAATGCTGTCGAGCAT
TGCAAACGCCATGTGTGGAACTAG

# Macromolecular_Interacting_Partner_15_GenBank_ID_Gene:
D00422

# Macromolecular_Interacting_Partner_15_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_15_Locus:
10q21-q22

# Macromolecular_Interacting_Partner_15_SNPs:
rs2070188; rs7869; rs1055754; rs2394846; rs762571; rs1015193; rs4237331; rs720295; rs7899959; rs7905774; rs7922255; rs885828; rs4237332; rs4747202; rs4747206; rs2070968; rs2394845; rs4747207; rs1900498; rs7350390; rs728289; rs2394844; rs6480560; rs9663508; rs2593163; rs749823; rs3747860; rs6480561; rs3819341; rs6480559; rs11000017; rs10740391; rs727414; rs2249814; rs2121535; rs7912803; rs2854986; rs7093252; rs10823852; rs3747855; rs11000020; rs16929408; rs11598989; rs11596365; rs4747203; rs12413995; rs10762483; rs4747204; rs4747208; rs11000016; rs12414356; rs2854992; rs11000025; rs727415; rs4747205; rs2166630; rs16913438; rs10762484; rs2854987; rs1900499; rs4454640; rs7917605; rs11000018; rs12413014; rs4746095; rs10762482; rs12415202; rs762573; rs12769743; rs1811087; rs2290023; rs7918049; rs11813373; rs9665661; rs11592448; rs9415055; rs11591470; rs7916568; rs7917015; rs11818931; rs2394843; rs11000019; rs4747209; rs7898293; rs4747210; rs11598617; rs9299509; rs9299510; rs12261323; rs1803650; rs11555015; rs11555016; rs11555021; rs11555017; rs1049882; rs1056711; rs1054851; rs1054293; rs11555018; rs41282246; rs11555020; rs36076120; rs14595; rs1053333; rs12844; rs28365839; rs1803651; rs2121536; rs7090110; rs11596605; rs35320964; rs34332602; rs2593164; rs11000024; rs7091271; rs9416009; rs2854984; rs5786051; rs34551152; rs11415214; rs2593162; rs5786050; rs959189; rs7898921; rs1894270; rs8181334; rs7477139; rs35814383; rs36035697; rs11595017; rs1867981; rs12266725; rs9416010; rs7072424; rs2854990; rs7098225; rs11277133; rs35027678; rs12220614; rs5786049; rs11000023; rs28535035; rs12571681; rs35131935; rs12247334; rs34701833; rs9415054; rs12782637; rs12252719; rs41307569; rs7922360; rs2854989; rs7911004; rs11285654; rs3061818; rs2593161; rs11000026; rs2854985; rs2854991; rs11305283; rs7899796; rs34761785; rs7072021; rs11000021; rs12247599; rs2854988; rs7076038; rs5007340; rs10566090; rs2305203; rs41306532; rs3891337; rs762572; rs5007339; rs10566091; rs2593160; rs3878001; rs35837949; rs7068078; rs35439306; rs12217799; rs35407936; rs34509443; rs35534537; rs2121537; rs35068924; rs11598625; rs34150455; rs28365838; rs7897854; rs34228343; rs10390; rs1054635; rs10762485; rs11000030; rs12252818; rs12416292; rs12774485; rs13377076; rs16929375; rs16929427; rs1867978; rs1992823; rs2290021; rs2290022; rs2394840; rs3802707; rs4746097; rs4747197; rs4747198; rs4747199; rs6480562; rs7085713; rs7092990; rs9415051; rs9415053

# Macromolecular_Interacting_Partner_15_General_References:
2515150; 2498298; 2842863; 1612590; 8323276; 1958198; 2013321; 2717620; 8370464; 2825202; 2868718; 3242555; 2209618; 3442600; 2845979; 3048308; 10562467; 7730378; 11180632; 10406958; 12510003; 10510427; 12518053; 7866401; 2302219; 2320574; 2019586; 2060627

# Macromolecular_Interacting_Partner_15_References:
16719769; 16824661; 16873684; 16887909

# Macromolecular_Interacting_Partner_16_ID:
7603

# Macromolecular_Interacting_Partner_16_Name:
Cystic fibrosis transmembrane conductance regulator

# Macromolecular_Interacting_Partner_16_Synonyms:
CFTR; cAMP- dependent chloride channel; ATP-binding cassette transporter sub- family C member 7

# Macromolecular_Interacting_Partner_16_Gene_Name:
CFTR

# Macromolecular_Interacting_Partner_16_Protein_Sequence:
>Cystic fibrosis transmembrane conductance regulator
MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRE
LASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIA
IYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQL
VSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGL
GRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAA
YVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQT
WYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRK
TSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEG
KIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIV
LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR
ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNS
ILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQ
MNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQG
QNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESI
PAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRN
NSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAP
MSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATV
PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHK
ALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIM
STLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKK
DDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRL
LNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVAD
EVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVT
YQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQA
ISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL

# Macromolecular_Interacting_Partner_16_Number_of_Residues:
1480

# Macromolecular_Interacting_Partner_16_Molecular_Weight:
168144

# Macromolecular_Interacting_Partner_16_Theoretical_pI:
9.02

# Macromolecular_Interacting_Partner_16_GO_Classification:
>>>
Function:  transporter activity
Function:  ion transporter activity
Function:  ion channel activity
Function:  anion channel activity
Function:  chloride channel activity
Function:  ATPase activity
Function:  hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Function:  ATPase activity, coupled to transmembrane movement of substances
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  ion transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_16_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_16_Specific_Function:
Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter

# Macromolecular_Interacting_Partner_16_Pathway:
Not Available

# Macromolecular_Interacting_Partner_16_Reaction:
Not Available

# Macromolecular_Interacting_Partner_16_Pfam_Domain_Function:
PF00664:ABC_membrane;
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_16_Signals:
None

# Macromolecular_Interacting_Partner_16_Transmembrane_Regions:
81-103
118-138
195-215
221-241
308-328
331-350
860-880
912-932
991-1011
1014-1034
1103-1123
1129-1149

# Macromolecular_Interacting_Partner_16_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_16_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_16_GenBank_ID_Protein:
180332

# Macromolecular_Interacting_Partner_16_SwissProt_ID:
CFTR_HUMAN (P13569)

# Macromolecular_Interacting_Partner_16_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_16_Genecard_id:
CFTR

# Macromolecular_Interacting_Partner_16_Geneatlas_id:
CFTR

# Macromolecular_Interacting_Partner_16_hgnc_id:
HGNC:1884

# Macromolecular_Interacting_Partner_16_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_16_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_16_Gene_Sequence:
>4443 bp
ATGCAGAGGTCGCCTCTGGAAAAGGCCAGCGTTGTCTCCAAACTTTTTTTCAGCTGGACC
AGACCAATTTTGAGGAAAGGATACAGACAGCGCCTGGAATTGTCAGACATATACCAAATC
CCTTCTGTTGATTCTGCTGACAATCTATCTGAAAAATTGGAAAGAGAATGGGATAGAGAG
CTGGCTTCAAAGAAAAATCCTAAACTCATTAATGCCCTTCGGCGATGTTTTTTCTGGAGA
TTTATGTTCTATGGAATCTTTTTATATTTAGGGGAAGTCACCAAAGCAGTACAGCCTCTC
TTACTGGGAAGAATCATAGCTTCCTATGACCCGGATAACAAGGAGGAACGCTCTATCGCG
ATTTATCTAGGCATAGGCTTATGCCTTCTCTTTATTGTGAGGACACTGCTCCTACACCCA
GCCATTTTTGGCCTTCATCACATTGGAATGCAGATGAGAATAGCTATGTTTAGTTTGATT
TATAAGAAGACTTTAAAGCTGTCAAGCCGTGTTCTAGATAAAATAAGTATTGGACAACTT
GTTAGTCTCCTTTCCAACAACCTGAACAAATTTGATGAAGGACTTGCATTGGCACATTTC
GTGTGGATCGCTCCTTTGCAAGTGGCACTCCTCATGGGGCTAATCTGGGAGTTGTTACAG
GCGTCTGCCTTCTGTGGACTTGGTTTCCTGATAGTCCTTGCCCTTTTTCAGGCTGGGCTA
GGGAGAATGATGATGAAGTACAGAGATCAGAGAGCTGGGAAGATCAGTGAAAGACTTGTG
ATTACCTCAGAAATGATTGAAAATATCCAATCTGTTAAGGCATACTGCTGGGAAGAAGCA
ATGGAAAAAATGATTGAAAACTTAAGACAAACAGAACTGAAACTGACTCGGAAGGCAGCC
TATGTGAGATACTTCAATAGCTCAGCCTTCTTCTTCTCAGGGTTCTTTGTGGTGTTTTTA
TCTGTGCTTCCCTATGCACTAATCAAAGGAATCATCCTCCGGAAAATATTCACCACCATC
TCATTCTGCATTGTTCTGCGCATGGCGGTCACTCGGCAATTTCCCTGGGCTGTACAAACA
TGGTATGACTCTCTTGGAGCAATAAACAAAATACAGGATTTCTTACAAAAGCAAGAATAT
AAGACATTGGAATATAACTTAACGACTACAGAAGTAGTGATGGAGAATGTAACAGCCTTC
TGGGAGGAGGGATTTGGGGAATTATTTGAGAAAGCAAAACAAAACAATAACAATAGAAAA
ACTTCTAATGGTGATGACAGCCTCTTCTTCAGTAATTTCTCACTTCTTGGTACTCCTGTC
CTGAAAGATATTAATTTCAAGATAGAAAGAGGACAGTTGTTGGCGGTTGCTGGATCCACT
GGAGCAGGCAAGACTTCACTTCTAATGATGATTATGGGAGAACTGGAGCCTTCAGAGGGT
AAAATTAAGCACAGTGGAAGAATTTCATTCTGTTCTCAGTTTTCCTGGATTATGCCTGGC
ACCATTAAAGAAAATATCATCTTTGGTGTTTCCTATGATGAATATAGATACAGAAGCGTC
ATCAAAGCATGCCAACTAGAAGAGGACATCTCCAAGTTTGCAGAGAAAGACAATATAGTT
CTTGGAGAAGGTGGAATCACACTGAGTGGAGGTCAACGAGCAAGAATTTCTTTAGCAAGA
GCAGTATACAAAGATGCTGATTTGTATTTATTAGACTCTCCTTTTGGATACCTAGATGTT
TTAACAGAAAAAGAAATATTTGAAAGCTGTGTCTGTAAACTGATGGCTAACAAAACTAGG
ATTTTGGTCACTTCTAAAATGGAACATTTAAAGAAAGCTGACAAAATATTAATTTTGAAT
GAAGGTAGCAGCTATTTTTATGGGACATTTTCAGAACTCCAAAATCTACAGCCAGACTTT
AGCTCAAAACTCATGGGATGTGATTCTTTCGACCAATTTAGTGCAGAAAGAAGAAATTCA
ATCCTAACTGAGACCTTACACCGTTTCTCATTAGAAGGAGATGCTCCTGTCTCCTGGACA
GAAACAAAAAAACAATCTTTTAAACAGACTGGAGAGTTTGGGGAAAAAAGGAAGAATTCT
ATTCTCAATCCAATCAACTCTATACGAAAATTTTCCATTGTGCAAAAGACTCCCTTACAA
ATGAATGGCATCGAAGAGGATTCTGATGAGCCTTTAGAGAGAAGGCTGTCCTTAGTACCA
GATTCTGAGCAGGGAGAGGCGATACTGCCTCGCATCAGCGTGATCAGCACTGGCCCCACG
CTTCAGGCACGAAGGAGGCAGTCTGTCCTGAACCTGATGACACACTCAGTTAACCAAGGT
CAGAACATTCACCGAAAGACAACAGCATCCACACGAAAAGTGTCACTGGCCCCTCAGGCA
AACTTGACTGAACTGGATATATATTCAAGAAGGTTATCTCAAGAAACTGGCTTGGAAATA
AGTGAAGAAATTAACGAAGAAGACTTAAAGGAGTGCCTTTTTGATGATATGGAGAGCATA
CCAGCAGTGACTACATGGAACACATACCTTCGATATATTACTGTCCACAAGAGCTTAATT
TTTGTGCTAATTTGGTGCTTAGTAATTTTTCTGGCAGAGGTGGCTGCTTCTTTGGTTGTG
CTGTGGCTCCTTGGAAACACTCCTCTTCAAGACAAAGGGAATAGTACTCATAGTAGAAAT
AACAGCTATGCAGTGATTATCACCAGCACCAGTTCGTATTATGTGTTTTACATTTACGTG
GGAGTAGCCGACACTTTGCTTGCTATGGGATTCTTCAGAGGTCTACCACTGGTGCATACT
CTAATCACAGTGTCGAAAATTTTACACCACAAAATGTTACATTCTGTTCTTCAAGCACCT
ATGTCAACCCTCAACACGTTGAAAGCAGGTGGGATTCTTAATAGATTCTCCAAAGATATA
GCAATTTTGGATGACCTTCTGCCTCTTACCATATTTGACTTCATCCAGTTGTTATTAATT
GTGATTGGAGCTATAGCAGTTGTCGCAGTTTTACAACCCTACATCTTTGTTGCAACAGTG
CCAGTGATAGTGGCTTTTATTATGTTGAGAGCATATTTCCTCCAAACCTCACAGCAACTC
AAACAACTGGAATCTGAAGGCAGGAGTCCAATTTTCACTCATCTTGTTACAAGCTTAAAA
GGACTATGGACACTTCGTGCCTTCGGACGGCAGCCTTACTTTGAAACTCTGTTCCACAAA
GCTCTGAATTTACATACTGCCAACTGGTTCTTGTACCTGTCAACACTGCGCTGGTTCCAA
ATGAGAATAGAAATGATTTTTGTCATCTTCTTCATTGCTGTTACCTTCATTTCCATTTTA
ACAACAGGAGAAGGAGAAGGAAGAGTTGGTATTATCCTGACTTTAGCCATGAATATCATG
AGTACATTGCAGTGGGCTGTAAACTCCAGCATAGATGTGGATAGCTTGATGCGATCTGTG
AGCCGAGTCTTTAAGTTCATTGACATGCCAACAGAAGGTAAACCTACCAAGTCAACCAAA
CCATACAAGAATGGCCAACTCTCGAAAGTTATGATTATTGAGAATTCACACGTGAAGAAA
GATGACATCTGGCCCTCAGGGGGCCAAATGACTGTCAAAGATCTCACAGCAAAATACACA
GAAGGTGGAAATGCCATATTAGAGAACATTTCCTTCTCAATAAGTCCTGGCCAGAGGGTG
GGCCTCTTGGGAAGAACTGGATCAGGGAAGAGTACTTTGTTATCAGCTTTTTTGAGACTA
CTGAACACTGAAGGAGAAATCCAGATCGATGGTGTGTCTTGGGATTCAATAACTTTGCAA
CAGTGGAGGAAAGCCTTTGGAGTGATACCACAGAAAGTATTTATTTTTTCTGGAACATTT
AGAAAAAACTTGGATCCCTATGAACAGTGGAGTGATCAAGAAATATGGAAAGTTGCAGAT
GAGGTTGGGCTCAGATCTGTGATAGAACAGTTTCCTGGGAAGCTTGACTTTGTCCTTGTG
GATGGGGGCTGTGTCCTAAGCCATGGCCACAAGCAGTTGATGTGCTTGGCTAGATCTGTT
CTCAGTAAGGCGAAGATCTTGCTGCTTGATGAACCCAGTGCTCATTTGGATCCAGTAACA
TACCAAATAATTAGAAGAACTCTAAAACAAGCATTTGCTGATTGCACAGTAATTCTCTGT
GAACACAGGATAGAAGCAATGCTGGAATGCCAACAATTTTTGGTCATAGAAGAGAACAAA
GTGCGGCAGTACGATTCCATCCAGAAACTGCTGAACGAGAGGAGCCTCTTCCGGCAAGCC
ATCAGCCCCTCCGACAGGGTGAAGCTCTTTCCCCACCGGAACTCAAGCAAGTGCAAGTCT
AAGCCCCAGATTGCTGCTCTGAAAGAGGAGACAGAAGAAGAGGTGCAAGATACAAGGCTT
TAG

# Macromolecular_Interacting_Partner_16_GenBank_ID_Gene:
M28668

# Macromolecular_Interacting_Partner_16_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_16_Locus:
7q31.2

# Macromolecular_Interacting_Partner_16_SNPs:
rs213950; rs1800100; rs1800107; rs11971167; rs35032490; rs1800076; rs1800136; rs1800130; rs1042077; rs1800095; rs1800094; rs1042180; rs17140308; rs10234329; rs1800501; rs213966; rs1429568; rs213977; rs2213958; rs2106155; rs213944; rs213951; rs213976; rs213987; rs756665; rs1469486; rs213954; rs117243; rs213936; rs1896888; rs213942; rs213956; rs213968; rs2082056; rs2518881; rs2246450; rs214167; rs2518873; rs885993; rs213955; rs213985; rs213943; rs172507; rs214157; rs2237722; rs213981; rs213952; rs213963; rs2027945; rs1800503; rs2078753; rs2283054; rs213935; rs213984; rs6466614; rs213980; rs11772396; rs4148692; rs7791289; rs2027944; rs10953847; rs2283058; rs213989; rs4727855; rs4148686; rs725188; rs7809485; rs1366917; rs2078754; rs7811667; rs213970; rs7789741; rs6968747; rs213965; rs957461; rs4148691; rs2188158; rs2237724; rs213983; rs2283057; rs214164; rs213972; rs6965682; rs213988; rs2283056; rs7786196; rs739378; rs213974; rs6969138; rs6466613; rs213986; rs428524; rs213946; rs2518879; rs980574; rs2254742; rs4148688; rs213945; rs2402228; rs6957018; rs213982; rs213953; rs1896887; rs213937; rs213964; rs7808474; rs213969; rs2237723; rs6949974; rs213973; rs1896886; rs213934; rs6466615; rs12534186; rs7812185; rs11974545; rs3808184; rs182460; rs2237721; rs7793127; rs10244810; rs6943105; rs7803222; rs213938; rs6979652; rs17449231; rs17140013; rs4148711; rs17450482; rs10487369; rs213958; rs2097609; rs10240654; rs3808183; rs7799504; rs4730787; rs718829; rs6957317; rs213967; rs213962; rs4148698; rs10240521; rs2188159; rs213949; rs17545644; rs17140229; rs17451754; rs17140169; rs6977764; rs10276533; rs214165; rs17449134; rs28517401; rs4148709; rs7797932; rs10249971; rs10262673; rs10487372; rs4148699; rs11770639; rs2402205; rs10262610; rs12538252; rs17139994; rs11978434; rs10266649; rs4148689; rs6971294; rs17547853; rs16870129; rs2402204; rs6466617; rs2518872; rs213961; rs12673260; rs10272001; rs17140297; rs7802924; rs17449197; rs17132549; rs6951141; rs3757802; rs3808186; rs4148706; rs6942892; rs113839; rs10155917; rs213933; rs12533524; rs7779015; rs3779543; rs4148690; rs7778541; rs10266116; rs10276355; rs6943074; rs214156; rs28415076; rs1820871; rs6466616; rs17547485; rs10224175; rs3808185; rs10487368; rs10487371; rs10281281; rs4148696; rs213957; rs7783208; rs10156138; rs6980032; rs17140095; rs28472519; rs2283055; rs10264892; rs2237725; rs34855237; rs2237726; rs10246649; rs28449716; rs213947; rs4148703; rs10276431; rs4148687; rs213979; rs17140299; rs17139984; rs17549557; rs17139943; rs35031429; rs34480179; rs35475211; rs7357343; rs34581373; rs1429566; rs2299444; rs2106152; rs34927137; rs35506750; rs4148717; rs35674779; rs34849722; rs34567454; rs4148724; rs35608825; rs34364422; rs34683806; rs7457653; rs35987553; rs1025342; rs1429562; rs6969578; rs35995554; rs34268361; rs4570091; rs34420782; rs35003065; rs34159932; rs6966254; rs34844161; rs10225787; rs36042090; rs2027946; rs34456592; rs13221882; rs35294574; rs34652497; rs2106153; rs11974978; rs35900505; rs6945467; rs35993090; rs34606983; rs17140174; rs718830; rs35855138; rs35775845; rs34674313; rs10239473; rs34331324; rs35334650; rs213975; rs34637736; rs1557630; rs34906874; rs1014620; rs1366913; rs213991; rs35533040; rs34034651; rs6944750; rs1429560; rs35384080; rs213971; rs35305858; rs35820454; rs12670673; rs35244428; rs35141759; rs4148714; rs2299445; rs35320768; rs34464201; rs214163; rs35715578; rs7811369; rs17547533; rs35130797; rs35097594; rs11764887; rs34823554; rs36046385; rs2188150; rs4148697; rs34201995; rs35403869; rs34638253; rs35783977; rs35388491; rs1429565; rs1429561; rs34309075; rs35553213; rs35504264; rs35278595; rs34979995; rs10487370; rs34587451; rs4148713; rs4148682; rs1013075; rs1800106; rs1800092; rs1800123; rs1800097; rs1800074; rs35722447; rs34911792; rs1800078; rs1800085; rs3034796; rs36210737; rs1800103; rs1800089; rs1800072; rs1800101; rs35396083; rs1800112; rs1800079; rs4727853; rs1800086; rs1800073; rs1800111; rs1800099; rs41290377; rs35516286; rs1800120; rs1800110; rs1800080; rs35813506; rs1800087; rs11531593; rs1801178; rs1800114; rs4148725; rs766874; rs1800093; rs1800081; rs1800109; rs1800113; rs1800088; rs1800071; rs1800122; rs1800131; rs1800117; rs1800075; rs1800096; rs1800119; rs1800135; rs1800116; rs1800121; rs1800082; rs1800104; rs2896225; rs1800132; rs1800115; rs1800129; rs35033453; rs1800090; rs1800118; rs1800134; rs1800102; rs1800083; rs1800077; rs1800105; rs1800084; rs1800133; rs1800108; rs1799834; rs1800128; rs1800070; rs1042166; rs34255446; rs3181644; rs35441557; rs28771969; rs3840657; rs34530771; rs35603916; rs34623881; rs34412203; rs35821559; rs35380228; rs34994599; rs34334041; rs35445590; rs36024281; rs3958007; rs35521564; rs35191413; rs4148704; rs35135985; rs1366914; rs13223629; rs213990; rs5886865; rs35178333; rs34239891; rs34000781; rs41281087; rs34016528; rs34507966; rs34463627; rs35855809; rs34114986; rs34222059; rs34624661; rs34628207; rs34560599; rs4148716; rs1975071; rs34558486; rs10281871; rs35666329; rs34231750; rs35433853; rs35824078; rs34448325; rs4148708; rs34362542; rs7357279; rs3993862; rs34851557; rs12536210; rs13437792; rs10677637; rs35189260; rs13238114; rs13232769; rs35924144; rs28590120; rs35714998; rs34442917; rs34225590; rs7457735; rs34795348; rs35207043; rs213948; rs34641663; rs13309662; rs34394575; rs35063389; rs35239381; rs34376865; rs35086442; rs35508774; rs34080224; rs35173620; rs34179723; rs35273275; rs35920406; rs34105750; rs13245896; rs34593753; rs35766024; rs2163099; rs10264962; rs34746362; rs508802; rs34668560; rs35248762; rs36001070; rs35283383; rs34517638; rs35228854; rs34066264; rs34812579; rs34589374; rs35396010; rs34518775; rs28558723; rs6955409; rs35396968; rs10229261; rs34870970; rs2518880; rs35633625; rs10550816; rs5886862; rs34511406; rs35194808; rs11762363; rs34248182; rs34339278; rs3840656; rs34400990; rs35904760; rs34277788; rs3034763; rs35313680; rs13239053; rs34410639; rs34360978; rs10614219; rs35728133; rs13438309; rs12668979; rs10232579; rs35859638; rs2023331; rs34027651; rs35260815; rs35066567; rs34735848; rs35616800; rs28594614; rs34276900; rs5886860; rs34914602; rs34433037; rs34010645; rs34047738; rs213941; rs13244984; rs35348526; rs28424587; rs35490261; rs35521194; rs596293; rs35162600; rs34383834; rs1896884; rs35342599; rs34732112; rs213940; rs4148701; rs4646205; rs13309661; rs34863610; rs34345001; rs34568382; rs36005386; rs4148720; rs34062555; rs35504055; rs34942345; rs10655920; rs1429567; rs4727854; rs28627628; rs4148710; rs36143091; rs34630111; rs34973305; rs35045003; rs34403015; rs34623047; rs4730788; rs34487154; rs34164989; rs34400048; rs35421075; rs35917213; rs13228570; rs35001289; rs12674149; rs4148715; rs17139964; rs35547457; rs35345004; rs10271445; rs35667431; rs35701757; rs35114123; rs4382409; rs34773874; rs35722251; rs11343468; rs11767017; rs422903; rs11443412; rs35346641; rs35988166; rs34193229; rs7457781; rs5886864; rs35836271; rs35199653; rs36107057; rs35700857; rs34035263; rs5886861; rs34886238; rs35889249; rs10264982; rs4148719; rs35541900; rs34484276; rs7357277; rs35942171; rs36033279; rs2896228; rs34717021; rs4148685; rs35105447; rs34736744; rs35434314; rs213959; rs34872089; rs11316515; rs35604119; rs10232232; rs35129070; rs35802750; rs35493996; rs35937137; rs34732049; rs35986679; rs10232573; rs4148695; rs34683874; rs7457732; rs35337904; rs4148702; rs34013793; rs35693763; rs34034688; rs35233944; rs34641511; rs34792223; rs35538989; rs34320215; rs10229820; rs5886859; rs34089570; rs35913327; rs35628262; rs35778610; rs35802833; rs3034759; rs34951012; rs34808223; rs34771810; rs34633427; rs36055118; rs34966030; rs35847360; rs35777371; rs35657815; rs35861262; rs34180375; rs35637601; rs35796593; rs35597709; rs34654194; rs35453278; rs13223623; rs34995970; rs35746597; rs34042174; rs28645294; rs35278352; rs11338754; rs3840654; rs3832534; rs2402206; rs11441201; rs35091062; rs35463889; rs35942697; rs3808189; rs5886870; rs35128028; rs4148693; rs1800502; rs35861555; rs34721490; rs35253939; rs35531523; rs34056920; rs34470402; rs10277521; rs4148684; rs3034794; rs35653285; rs35011694; rs3824027; rs36053606; rs34209052; rs34179833; rs35453239; rs35797246; rs36057583; rs3216281; rs34689837; rs34197594; rs11335020; rs35641133; rs2163100; rs13231082; rs34977231; rs10229250; rs34314195; rs35254620; rs34489981; rs4148707; rs34229114; rs35113266; rs11393719; rs34181727; rs35197837; rs10604610; rs35737756; rs35098671; rs34050492; rs7455314; rs35753200; rs35480497; rs35242561; rs35860379; rs10249707; rs34858277; rs34599010; rs35141610; rs35250799; rs4148722; rs35537814; rs35225336; rs34092224; rs34174646; rs9691378; rs34610095; rs35980778; rs1429564; rs2157735; rs5886867; rs213939; rs1366916; rs34858416; rs11343448; rs35071293; rs35682006; rs35784120; rs213960; rs35715131; rs34466297; rs10708994; rs11430349; rs35376221; rs35545882; rs34063663; rs3035712; rs34208245; rs4148694; rs11305516; rs13238110; rs34131894; rs34007053; rs35087944; rs10591889; rs34877038; rs7350044; rs35388998; rs35921938; rs35447324; rs34990919; rs35358095; rs12536236; rs34004297; rs34487764; rs34543279; rs13245053; rs5886869; rs2299443; rs34123455; rs35395275; rs4439060; rs35573776; rs35164769; rs13220943; rs4148712; rs1583061; rs3993863; rs213978; rs35131082; rs34419743; rs35183640; rs34021589; rs34752468; rs35050470; rs35806580; rs10237367; rs35313962; rs7457780; rs2299442; rs5886866; rs1366915; rs11299909; rs35357994; rs13242295; rs11299910; rs34644747; rs35050594; rs35810177; rs9690726; rs34477331; rs34451243; rs34171310; rs3958006; rs34779265; rs10614220; rs34491799; rs34018535; rs35381245; rs13240972; rs35773231; rs35546286; rs34285652; rs35028662; rs1800687; rs35647432; rs11393567; rs35003674; rs35547336; rs34830471; rs214166; rs34280233; rs35158649; rs35470760; rs35026177; rs35916162; rs35147826; rs34671892; rs13225696; rs717918; rs35314519; rs10229103; rs34263755; rs35915869; rs36066143; rs34047196; rs2896226; rs10232910; rs34168687; rs35828781; rs11770751; rs35142890; rs34260394; rs34020733; rs35134989; rs35537576; rs35347718; rs34193416; rs35144548; rs4148721; rs34983001; rs36082161; rs34453441; rs36026445; rs3035687; rs10649319; rs35435021; rs35036571; rs35615558; rs35853854; rs34607500; rs13223535; rs34861365; rs10260471; rs4148718; rs35454375; rs3840655; rs35953502; rs10229115; rs13232912; rs34427586; rs3808187; rs34548759; rs1013076; rs34210368; rs34465975; rs4148683; rs34366889; rs34347530; rs35871908; rs10227664; rs10245438; rs10270610; rs10272233; rs11764070; rs13237279; rs1366912; rs17139920; rs17139922; rs17139925; rs17139929; rs17544734; rs177284; rs214159; rs214160; rs43035; rs43036; rs6943317; rs713134; rs7810506

# Macromolecular_Interacting_Partner_16_General_References:
2475911; 1710598; 12853948; 12690205; 1377674; 9385646; 11707463; 1378801; 9517543; 11304524; 1284534; 1695717; 2236053; 1710600; 1284466; 1284468; 1284530; 1284529; 7680525; 7683628; 7683954; 7505694; 7504969; 7522211; 7513296; 7525450; 7520022; 7524913; 7524909; 7517264; 8081395; 7529962; 7539342; 7544319; 8522333; 7537150; 7541273; 7581407; 7543567; 7541510; 8800923; 8829633; 8723693; 8723695; 8956039; 9067761; 9101301; 9222768; 9375855; 9401006; 9443874; 9521595; 9921909; 9736778; 9482579; 9554753; 9452048; 9452054; 9452073; 10094564

# Macromolecular_Interacting_Partner_16_References:
16643279; 16859673; 16987954; 17012229

# Macromolecular_Interacting_Partner_17_ID:
7612

# Macromolecular_Interacting_Partner_17_Name:
Vascular endothelial growth factor A precursor

# Macromolecular_Interacting_Partner_17_Synonyms:
VEGF-A; Vascular permeability factor; VPF

# Macromolecular_Interacting_Partner_17_Gene_Name:
VEGF

# Macromolecular_Interacting_Partner_17_Protein_Sequence:
>Vascular endothelial growth factor A precursor
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD
IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM
SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPG
PHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR

# Macromolecular_Interacting_Partner_17_Number_of_Residues:
232

# Macromolecular_Interacting_Partner_17_Molecular_Weight:
27043

# Macromolecular_Interacting_Partner_17_Theoretical_pI:
9.08

# Macromolecular_Interacting_Partner_17_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_17_General_Function:
Not Available

# Macromolecular_Interacting_Partner_17_Specific_Function:
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145

# Macromolecular_Interacting_Partner_17_Pathway:
Not Available

# Macromolecular_Interacting_Partner_17_Reaction:
Not Available

# Macromolecular_Interacting_Partner_17_Pfam_Domain_Function:
PF00341:PDGF

# Macromolecular_Interacting_Partner_17_Signals:
1-26

# Macromolecular_Interacting_Partner_17_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_17_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_17_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_17_GenBank_ID_Protein:
181971

# Macromolecular_Interacting_Partner_17_SwissProt_ID:
VEGFA_HUMAN (P15692)

# Macromolecular_Interacting_Partner_17_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_17_Genecard_id:
VEGF

# Macromolecular_Interacting_Partner_17_Geneatlas_id:
VEGF

# Macromolecular_Interacting_Partner_17_hgnc_id:
HGNC:12680

# Macromolecular_Interacting_Partner_17_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_17_Subcellular_Location:
Secreted protein. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell- associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin

# Macromolecular_Interacting_Partner_17_Gene_Sequence:
>576 bp
ATGAACTTTCTGCTGTCTTGGGTGCATTGGAGCCTCGCCTTGCTGCTCTACCTCCACCAT
GCCAAGTGGTCCCAGGCTGCACCCATGGCAGAAGGAGGAGGGCAGAATCATCACGAAGTG
GTGAAGTTCATGGATGTCTATCAGCGCAGCTACTGCCATCCAATCGAGACCCTGGTGGAC
ATCTTCCAGGAGTACCCTGATGAGATCGAGTACATCTTCAAGCCATCCTGTGTGCCCCTG
ATGCGATGCGGGGGCTGCTGCAATGACGAGGGCCTGGAGTGTGTGCCCACTGAGGAGTCC
AACATCACCATGCAGATTATGCGGATCAAACCTCACCAAGGCCAGCACATAGGAGAGATG
AGCTTCCTACAGCACAACAAATGTGAATGCAGACCAAAGAAAGATAGAGCAAGACAAGAA
AATCCCTGTGGGCCTTGCTCAGAGCGGAGAAAGCATTTGTTTGTACAAGATCCGCAGACG
TGTAAATGTTCCTGCAAAAACACAGACTCGCGTTGCAAGGCGAGGCAGCTTGAGTTAAAC
GAACGTACTTGCAGATGTGACAAGCCGAGGCGGTGA

# Macromolecular_Interacting_Partner_17_GenBank_ID_Gene:
M32977

# Macromolecular_Interacting_Partner_17_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_17_Locus:
6p12

# Macromolecular_Interacting_Partner_17_SNPs:
Not Available

# Macromolecular_Interacting_Partner_17_General_References:
2479986; 2479987; 1711045; 1791831; 1567395; 9054410; 9878851; 9450968; 10464055; 14574404; 7678805; 2584205; 10067980; 9207067; 9351807; 9922142; 9336848; 9634701; 11427521

# Macromolecular_Interacting_Partner_17_References:
16706581; 16809546; 17000881; 17070516

# Macromolecular_Interacting_Partner_18_ID:
7615

# Macromolecular_Interacting_Partner_18_Name:
cAMP response element-binding protein

# Macromolecular_Interacting_Partner_18_Synonyms:
CREB

# Macromolecular_Interacting_Partner_18_Gene_Name:
CREB1

# Macromolecular_Interacting_Partner_18_Protein_Sequence:
>cAMP response elementbinding protein
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN
GQTVQVHGVIQAAQPSVIQSPQVQTVQSSCKDLKRLFSGTQISTIAESEDSQESVDSVTD
SQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSG
QYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQV
VVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAAREC
RRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD

# Macromolecular_Interacting_Partner_18_Number_of_Residues:
341

# Macromolecular_Interacting_Partner_18_Molecular_Weight:
36688

# Macromolecular_Interacting_Partner_18_Theoretical_pI:
5.24

# Macromolecular_Interacting_Partner_18_GO_Classification:
>>>
Function:  protein binding
Function:  transcription factor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_18_General_Function:
Not Available

# Macromolecular_Interacting_Partner_18_Specific_Function:
This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE

# Macromolecular_Interacting_Partner_18_Pathway:
Not Available

# Macromolecular_Interacting_Partner_18_Reaction:
Not Available

# Macromolecular_Interacting_Partner_18_Pfam_Domain_Function:
PF00170:bZIP_1;
PF02173:pKID

# Macromolecular_Interacting_Partner_18_Signals:
None

# Macromolecular_Interacting_Partner_18_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_18_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_18_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_18_GenBank_ID_Protein:
240429

# Macromolecular_Interacting_Partner_18_SwissProt_ID:
CREB1_HUMAN (P16220)

# Macromolecular_Interacting_Partner_18_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_18_Genecard_id:
CREB1

# Macromolecular_Interacting_Partner_18_Geneatlas_id:
CREB1

# Macromolecular_Interacting_Partner_18_hgnc_id:
HGNC:2345

# Macromolecular_Interacting_Partner_18_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_18_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_18_Gene_Sequence:
>984 bp
ATGACCATGGAATCTGGAGCCGAGAACCAGCAGAGTGGAGATGCAGCTGTAACAGAAGCT
GAAAACCAACAAATGACAGTTCAAGCCCAGCCACAGATTGCCACATTAGCCCAGGTATCT
ATGCCAGCAGCTCATGCAACATCATCTGCTCCCACCGTAACTCTAGTACAGCTGCCCAAT
GGGCAGACAGTTCAAGTCCATGGAGTCATTCAGGCGGCCCAGCCATCAGTTATTCAGTCT
CCACAAGTCCAAACAGTTCAGATTTCAACTATTGCAGAAAGTGAAGATTCACAGGAGTCA
GTGGATAGTGTAACTGATTCCCAAAAGCGAAGGGAAATTCTTTCAAGGAGGCCTTCCTAC
AGGAAAATTTTGAATGACTTATCTTCTGATGCACCAGGAGTGCCAAGGATTGAAGAAGAG
AAGTCTGAAGAGGAGACTTCAGCACCTGCCATCACCACTGTAACGGTGCCAACTCCAATT
TACCAAACTAGCAGTGGACAGTATATTGCCATTACCCAGGGAGGAGCAATACAGCTGGCT
AACAATGGTACCGATGGGGTACAGGGCCTGCAAACATTAACCATGACCAATGCAGCAGCC
ACTCAGCCGGGTACTACCATTCTACAGTATGCACAGACCACTGATGGACAGCAGATCTTA
GTGCCCAGCAACCAAGTTGTTGTTCAAGCTGCCTCTGGAGACGTACAAACATACCAGATT
CGCACAGCACCCACTAGCACTATTGCCCCTGGAGTTGTTATGGCATCCTCCCCAGCACTT
CCTACACAGCCTGCTGAAGAAGCAGCACGAAAGAGAGAGGTCCGTCTAATGAAGAACAGG
GAAGCAGCTCGAGAGTGTCGTAGAAAGAAGAAAGAATATGTGAAATGTTTAGAAAACAGA
GTGGCAGTGCTTGAAAATCAAAACAAGACATTGATTGAGGAGCTAAAAGCACTTAAGGAC
CTTTACTGCCACAAATCAGATTAA

# Macromolecular_Interacting_Partner_18_GenBank_ID_Gene:
S72459

# Macromolecular_Interacting_Partner_18_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_18_Locus:
2q34

# Macromolecular_Interacting_Partner_18_SNPs:
rs2709357; rs2709356; rs889895; rs2551917; rs2709400; rs2551640; rs2709360; rs2042486; rs2551642; rs4675682; rs2709359; rs2551639; rs11883511; rs7590024; rs2709355; rs2551641; rs2709398; rs2360970; rs2042485; rs12466352; rs2709399; rs2709387; rs2551920; rs2551923; rs2464978; rs6740584; rs2254137; rs2551921; rs2551919; rs9679258; rs9288383; rs3770704; rs13397461; rs12694087; rs2551922; rs16839883; rs2194430; rs11904814; rs2709393; rs3730300; rs2247053; rs10199872; rs2551924; rs2551644; rs2059336; rs17811997; rs7603049; rs11692041; rs7570673; rs3730276; rs13393250; rs2551645; rs2709402; rs2709388; rs2464977; rs17515722; rs2551926; rs13398837; rs10932201; rs2952766; rs12477957; rs2709392; rs2464976; rs2551638; rs35349697; rs34884247; rs35342276; rs12992351; rs12467170; rs13422727; rs13016095; rs10561230; rs10202862; rs35952037; rs35924297; rs35303892; rs3836057; rs1050641; rs2709354; rs35153918; rs4024317; rs35539388; rs11356093; rs12998737; rs11397523; rs35506841; rs9677382; rs35379208; rs12992752; rs12470697; rs13029939; rs12467171; rs13422622; rs35711096; rs35714520; rs34172985; rs10598911; rs4024318; rs35004775; rs3836058; rs10568689; rs13422714; rs35282925; rs35047346; rs34797824; rs7582473; rs35896795; rs6729764; rs12614101; rs7603975; rs2709385; rs13018430; rs34411431; rs2709403; rs34628133; rs2551647; rs7589804; rs34775277; rs35762508; rs2551646; rs28853093; rs17515729; rs13431009; rs2551918; rs7558859; rs34583259; rs2551648; rs34550164; rs2551925; rs6715664; rs2709404; rs35735523; rs7576411; rs4101544; rs34903544; rs3951781; rs34242417; rs1064176; rs4675684; rs6705627; rs11311967; rs13412269; rs34309640; rs10185283; rs11684107; rs36108540; rs35955521; rs5838079; rs35019306; rs35728983; rs2709389; rs34275460; rs34379142; rs2709362; rs35000643; rs35261053; rs35119018; rs13409275; rs2709381; rs34177886; rs12478868; rs34145676; rs2709378; rs2551643; rs7588606; rs34127936; rs35865443; rs12998128; rs2709377; rs11319861; rs11335782; rs35907148; rs34317727; rs35318842; rs1045780; rs1045790; rs12999688; rs13029936; rs13386109; rs1806584; rs1806585; rs2551928; rs2551931; rs2709371; rs2709373; rs2709374; rs2709376; rs2709396; rs6785; rs7569963

# Macromolecular_Interacting_Partner_18_General_References:
2142528; 2196176; 1966745; 2974179; 1831258; 8381074; 7608156

# Macromolecular_Interacting_Partner_18_References:
16627932; 16633733; 16640787; 16645134

# Macromolecular_Interacting_Partner_19_ID:
7624

# Macromolecular_Interacting_Partner_19_Name:
Pituitary adenylate cyclase-activating polypeptide precursor

# Macromolecular_Interacting_Partner_19_Synonyms:
PACAP[Contains: PACAP-related peptide; PRP-48; Pituitary adenylate cyclase-activating polypeptide 27; PACAP-27; PACAP27; Pituitary adenylate cyclase-activating polypeptide 38; PACAP-38; PACAP38]

# Macromolecular_Interacting_Partner_19_Gene_Name:
ADCYAP1

# Macromolecular_Interacting_Partner_19_Protein_Sequence:
>Pituitary adenylate cyclaseactivating polypeptide precursor
MTMCSGARLALLVYGIIMHSSVYSSPAAAGLRFPGIRPEEEAYGEDGNPLPDFDGSEPPG
AGSPASAPRAAAAWYRPAGRRDVAHGILNEAYRKVLDQLSAGKHLQSLVARGVGGSLGGG
AGDDAEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIAYL

# Macromolecular_Interacting_Partner_19_Number_of_Residues:
176

# Macromolecular_Interacting_Partner_19_Molecular_Weight:
18836

# Macromolecular_Interacting_Partner_19_Theoretical_pI:
10.24

# Macromolecular_Interacting_Partner_19_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_19_General_Function:
Not Available

# Macromolecular_Interacting_Partner_19_Specific_Function:
Stimulates adenylate cyclase in pituitary cells

# Macromolecular_Interacting_Partner_19_Pathway:
Not Available

# Macromolecular_Interacting_Partner_19_Reaction:
Not Available

# Macromolecular_Interacting_Partner_19_Pfam_Domain_Function:
PF00123:Hormone_2

# Macromolecular_Interacting_Partner_19_Signals:
1-24

# Macromolecular_Interacting_Partner_19_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_19_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_19_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_19_GenBank_ID_Protein:
245806

# Macromolecular_Interacting_Partner_19_SwissProt_ID:
PACA_HUMAN (P18509)

# Macromolecular_Interacting_Partner_19_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_19_Genecard_id:
ADCYAP1

# Macromolecular_Interacting_Partner_19_Geneatlas_id:
ADCYAP1

# Macromolecular_Interacting_Partner_19_hgnc_id:
HGNC:241

# Macromolecular_Interacting_Partner_19_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_19_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_19_Gene_Sequence:
>531 bp
ATGACCATGTGTAGCGGAGCGAGGCTGGCCCTGCTGGTCTATGGGATAATCATGCACAGC
AGCGTCTACAGCTCACCTGCCGCCGCCGGACTCCGGTTCCCCGGGATCAGGCCAGAGGAA
GAGGCGTACGGCGAGGACGGAAACCCGCTGCCAGACTTCGGTGGCTCGGAGCCGCCGGGC
GCAGGGAGCCCCGCCTCCGCGCCGCGCGCCGCCGCCGCCTGGTACCGCCCGGCCGGGAGA
AGAGATGTCGCCCACGGGATCCTTAACGAGGCCTACCGCAAAGTGCTGGACCAGCTGTCC
GCCGGGAAGCACCTGCAGTCGCTCGTGGCCCGGGGCGTGGGTGGGAGCCTCGGCGGCGGC
GCGGGGGACGACGCGGAGCCGCTCTCCAAGCGCCACTCGGACGGGATCTTCACGGACAGC
TACAGCCGCTACCGGAAACAAATGGCTGTCAAGAAGTACTTGGCGGCCGTCCTAGGGAAG
AGGTATAAACAAAGGGTTAAAAACAAAGGACGCCGAATAGCTTATTTGTAG

# Macromolecular_Interacting_Partner_19_GenBank_ID_Gene:
S83513

# Macromolecular_Interacting_Partner_19_Chromosome_Location:
Chromosome:18

# Macromolecular_Interacting_Partner_19_Locus:
18p11

# Macromolecular_Interacting_Partner_19_SNPs:
rs2856966; rs8192597; rs2231187; rs1610037; rs1006567; rs2231189; rs928978; rs2846586; rs928980; rs2231185; rs11874747; rs2846585; rs8095096; rs8192595; rs940196; rs2231183; rs1893154; rs2231181; rs2846584; rs2688998; rs2688999; rs1893153; rs2689000; rs2856965; rs11540551; rs8192594; rs35305428; rs35546791; rs35716332; rs2231190; rs35472231; rs2231188; rs10609842; rs34903313; rs35018620; rs35424542; rs9959930; rs28517455; rs928979; rs2231186; rs2689002; rs11410786; rs34443231; rs2846811; rs34965985; rs33986139; rs8095212; rs8192599; rs2231184; rs8192598; rs2846812; rs3833194; rs12967282; rs8192596; rs8086678; rs34860740; rs12605354; rs2231182; rs2689001; rs2231180; rs10775442; rs10853365; rs11081414; rs11081458; rs11659736; rs11663168; rs11663172; rs11663363; rs11665625; rs12605876; rs12961210; rs12967004; rs12967480; rs1581469; rs1608443; rs1608446; rs1608447; rs17500692; rs17501715; rs17501755; rs17579719; rs2515911; rs2689004; rs2689005; rs2689007; rs2846577; rs2846578; rs2846579; rs2846581; rs2846582; rs2846583; rs2846807; rs2846808; rs2846809; rs2846813; rs2846830; rs2856964; rs7228988; rs7242260; rs8094717; rs8096056; rs948233; rs948234; rs948235; rs9635869; rs9635870; rs9957039

# Macromolecular_Interacting_Partner_19_General_References:
1739432; 1730060; 2302217; 8504103; 1483839; 11968092

# Macromolecular_Interacting_Partner_19_References:
17000774

# Macromolecular_Interacting_Partner_20_ID:
5772

# Macromolecular_Interacting_Partner_20_Name:
Acetylcholinesterase precursor

# Macromolecular_Interacting_Partner_20_Synonyms:
AChE

# Macromolecular_Interacting_Partner_20_Gene_Name:
ACHE

# Macromolecular_Interacting_Partner_20_Protein_Sequence:
>Acetylcholinesterase precursor
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL

# Macromolecular_Interacting_Partner_20_Number_of_Residues:
614

# Macromolecular_Interacting_Partner_20_Molecular_Weight:
67797

# Macromolecular_Interacting_Partner_20_Theoretical_pI:
6.24

# Macromolecular_Interacting_Partner_20_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  cholinesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_20_General_Function:
Lipid transport and metabolism 

# Macromolecular_Interacting_Partner_20_Specific_Function:
Rapidly hydrolyzes choline released into the synapse

# Macromolecular_Interacting_Partner_20_Pathway:
map00564  Glycerophospholipid metabolism

# Macromolecular_Interacting_Partner_20_Reaction:
acetylcholine + H2O = choline + acetate

# Macromolecular_Interacting_Partner_20_Pfam_Domain_Function:
PF08674:AChE_tetra;
PF00135:COesterase

# Macromolecular_Interacting_Partner_20_Signals:
1-31

# Macromolecular_Interacting_Partner_20_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_20_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_20_EC_Link:
EC 3.1.1.7

# Macromolecular_Interacting_Partner_20_GenBank_ID_Protein:
177975

# Macromolecular_Interacting_Partner_20_SwissProt_ID:
ACES_HUMAN (P22303)

# Macromolecular_Interacting_Partner_20_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_20_Genecard_id:
ACHE

# Macromolecular_Interacting_Partner_20_Geneatlas_id:
ACHE

# Macromolecular_Interacting_Partner_20_hgnc_id:
HGNC:108

# Macromolecular_Interacting_Partner_20_PDB_ID:
1F8U

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_20_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_20_Gene_Sequence:
>1845 bp
ATGAGGCCCCCGCAGTGTCTGCTGCACACGCCTTCCCTGGCTTCCCCACTCCTTCTCCTC
CTCCTCTGGCTCCTGGGTGGAGGAGTGGGGGCTGAGGGCCGGGAGGATGCAGAGCTGCTG
GTGACGGTGCGTGGGGGCCGGCTGCGGGGCATTCGCCTGAAGACCCCCGGGGGCCCTGTC
TCTGCTTTCCTGGGCATCCCCTTTGCGGAGCCACCCATGGGACCCCGTCGCTTTCTGCCA
CCGGAGCCCAAGCAGCCTTGGTCAGGGGTGGTAGACGCTACAACCTTCCAGAGTGTCTGC
TACCAATATGTGGACACCCTATACCCAGGTTTTGAGGGCACCGAGATGTGGAACCCCAAC
CGTGAGCTGAGCGAGGACTGCCTGTACCTCAACGTGTGGACACCATACCCCCGGCCTACA
TCCCCCACCCCTGTCCTCGTCTGGATCTATGGGGGTGGCTTCTACAGTGGGGCCTCCTCC
TTGGACGTGTACGATGGCCGCTTCTTGGTACAGGCCGAGAGGACTGTGCTGGTGTCCATG
AACTACCGGGTGGGAGCCTTTGGCTTCCTGGCCCTGCCGGGGAGCCGAGAGGCCCCGGGC
AATGTGGGTCTCCTGGATCAGAGGCTGGCCCTGCAGTGGGTGCAGGAGAACGTGGCAGCC
TTCGGGGGTGACCCGACATCAGTGACGCTGTTTGGGGAGAGCGCGGGAGCCGCCTCGGTG
GGCATGCACCTGCTGTCCCCGCCCAGCCGGGGCCTGTTCCACAGGGCCGTGCTGCAGAGC
GGTGCCCCCAATGGACCCTGGGCCACGGTGGGCATGGGAGAGGCCCGTCGCAGGGCCACG
CAGCTGGCCCACCTTGTGGGCTGTCCTCCAGGCGGCACTGGTGGGAATGACACAGAGCTG
GTAGCCTGCCTTCGGACACGACCAGCGCAGGTCCTGGTGAACCACGAATGGCACGTGCTG
CCTCAAGAAAGCGTCTTCCGGTTCTCCTTCGTGCCTGTGGTAGATGGAGACTTCCTCAGT
GACACCCCAGAGGCCCTCATCAACGCGGGAGACTTCCACGGCCTGCAGGTGCTGGTGGGT
GTGGTGAAGGATGAGGGCTCGTATTTTCTGGTTTACGGGGCCCCAGGCTTCAGCAAAGAC
AACGAGTCTCTCATCAGCCGGGCCGAGTTCCTGGCCGGGGTGCGGGTCGGGGTTCCCCAG
GTAAGTGACCTGGCAGCCGAGGCTGTGGTCCTGCATTACACAGACTGGCTGCATCCCGAG
GACCCGGCACGCCTGAGGGAGGCCCTGAGCGATGTGGTGGGCGACCACAATGTCGTGTGC
CCCGTGGCCCAGCTGGCTGGGCGACTGGCTGCCCAGGGTGCCCGGGTCTACGCCTACGTC
TTTGAACACCGTGCTTCCACGCTCTCCTGGCCCCTGTGGATGGGGGTGCCCCACGGCTAC
GAGATCGAGTTCATCTTTGGGATCCCCCTGGACCCCTCTCGAAACTACACGGCAGAGGAG
AAAATCTTCGCCCAGCGACTGATGCGATACTGGGCCAACTTTGCCCGCACAGGGGATCCC
AATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAG
TACGTTAGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGC
GCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCCACCGACACGCTCGACGAGGCG
GAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAAC
CAGTTCGACCACTACAGCAAGCAGGATCGCTGCTCAGACCTGTGA

# Macromolecular_Interacting_Partner_20_GenBank_ID_Gene:
M55040

# Macromolecular_Interacting_Partner_20_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_20_Locus:
7q22

# Macromolecular_Interacting_Partner_20_SNPs:
Not Available

# Macromolecular_Interacting_Partner_20_General_References:
2263619; 12853948; 11239002; 8299725; 2714437; 1748670; 1517212; 9640563; 11053835; 8488842

# Macromolecular_Interacting_Partner_20_References:
16882455; 16924422

# Macromolecular_Interacting_Partner_21_ID:
7636

# Macromolecular_Interacting_Partner_21_Name:
Brain-derived neurotrophic factor precursor

# Macromolecular_Interacting_Partner_21_Synonyms:
BDNF; Abrineurin

# Macromolecular_Interacting_Partner_21_Gene_Name:
BDNF

# Macromolecular_Interacting_Partner_21_Protein_Sequence:
>Brainderived neurotrophic factor precursor
MTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLA
DTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAA
NMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQY
FYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCT
LTIKRGR

# Macromolecular_Interacting_Partner_21_Number_of_Residues:
247

# Macromolecular_Interacting_Partner_21_Molecular_Weight:
27818

# Macromolecular_Interacting_Partner_21_Theoretical_pI:
9.01

# Macromolecular_Interacting_Partner_21_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_21_General_Function:
Not Available

# Macromolecular_Interacting_Partner_21_Specific_Function:
Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability

# Macromolecular_Interacting_Partner_21_Pathway:
Not Available

# Macromolecular_Interacting_Partner_21_Reaction:
Not Available

# Macromolecular_Interacting_Partner_21_Pfam_Domain_Function:
PF00243:NGF

# Macromolecular_Interacting_Partner_21_Signals:
1-18

# Macromolecular_Interacting_Partner_21_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_21_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_21_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_21_GenBank_ID_Protein:
179403

# Macromolecular_Interacting_Partner_21_SwissProt_ID:
BDNF_HUMAN (P23560)

# Macromolecular_Interacting_Partner_21_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_21_Genecard_id:
BDNF

# Macromolecular_Interacting_Partner_21_Geneatlas_id:
BDNF

# Macromolecular_Interacting_Partner_21_hgnc_id:
HGNC:1033

# Macromolecular_Interacting_Partner_21_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_21_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_21_Gene_Sequence:
>744 bp
ATGACCATCCTTTTCCTTACTATGGTTATTTCATACTTTGGTTGCATGAAGGCTGCCCCC
ATGAAAGAAGCAAACATCCGAGGACAAGGTGGCTTGGCCTACCCAGGTGTGCGGACCCAT
GGGACTCTGGAGAGCGTGAATGGGCCCAAGGCAGGTTCAAGAGGCTTGACATCATTGGCT
GACACTTTCGAACACGTGATAGAAGAGCTGTTGGATGAGGACCAGAAAGTTCGGCCCAAT
GAAGAAAACAATAAGGACGCAGACTTGTACACGTCCAGGGTGATGCTCAGTAGTCAAGTG
CCTTTGGAGCCTCCTCTTCTCTTTCTGCTGGAGGAATACAAAAATTACCTAGATGCTGCA
AACATGTCCATGAGGGTCCGGCGCCACTCTGACCCTGCCCGCCGAGGGGAGCTGAGCGTG
TGTGACAGTATTAGTGAGTGGGTAACGGCGGCAGACAAAAAGACTGCAGTGGACATGTCG
GGCGGGACGGTCACAGTCCTTGAAAAGGTCCCTGTATCAAAAGGCCAACTGAAGCAATAC
TTCTACGAGACCAAGTGCAATCCCATGGGTTACACAAAAGAAGGCTGCAGGGGCATAGAC
AAAAGGCATTGGAACTCCCAGTGCCGAACTACCCAGTCGTACGTGCGGGCCCTTACCATG
GATAGCAAAAAGAGAATTGGCTGGCGATTCATAAGGATAGACACTTCTTGTGTATGTACA
TTGACCATTAAAAGGGGAAGATAG

# Macromolecular_Interacting_Partner_21_GenBank_ID_Gene:
M37762

# Macromolecular_Interacting_Partner_21_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_21_Locus:
11p13

# Macromolecular_Interacting_Partner_21_SNPs:
rs11030119; rs1013402; rs6484320; rs7103873; rs7104207; rs2030324; rs7103411; rs2030323; rs16917237; rs2049046; rs10767664; rs7482752; rs7934165; rs988748; rs962369; rs10835211; rs11030121; rs7127507; rs11826087; rs10767665; rs7483223; rs12293082; rs1158615; rs10835214; rs10835215; rs10767662; rs10160339; rs7944119; rs13306221; rs10219241; rs4923468; rs12575096; rs11030117; rs11030116; rs7931214; rs962368; rs10767666; rs11030112; rs36211437; rs4923466; rs6484321; rs12807356; rs36211436; rs12292980; rs11030120; rs7926362; rs2883187; rs7931755; rs12273363; rs36211441; rs28383487; rs4333984; rs1829469; rs34775831; rs12804186; rs10603158; rs4633417; rs982495; rs7937405; rs34640261; rs36186721; rs35882286; rs36211435; rs36154247; rs34000680; rs11500197; rs35365597; rs11428064; rs7930226; rs35038967; rs10626744; rs1949513; rs41282914; rs11030118; rs5790663; rs41282918; rs36137816; rs34782136; rs34097841; rs34006299; rs1967554; rs4505020; rs4378341; rs10835213; rs34137922; rs11375149; rs7942023; rs33973780; rs35952596; rs34379767; rs10767663; rs34590225; rs34710639; rs36080697; rs41282916; rs7126155; rs7943622; rs12790234; rs12099399; rs34043390; rs4542361; rs34845916; rs4385847; rs35397930; rs35092401; rs4258332; rs12801337; rs12790808; rs12289769; rs35935579; rs4922793; rs33943251; rs11607106; rs35791154; rs34321446; rs6484326; rs35699873; rs35168316; rs11030115; rs36162242; rs10835216; rs35920578; rs34006734; rs11030111; rs4390309; rs35641613; rs11030113; rs4923467; rs41274436; rs41274440; rs41274434; rs41274438; rs41274442; rs7929344; rs34194909; rs34578636; rs1048218; rs1048220; rs1048221; rs1048241; rs10501087; rs10767658; rs10767660; rs10767661; rs10835210; rs11030098; rs11030101; rs11030102; rs11030104; rs11030107; rs11030108; rs11030109; rs11030123; rs11819808; rs11825814; rs11826739; rs12273539; rs12284158; rs12284724; rs12288512; rs12291063; rs12291186; rs12419948; rs12790077; rs1401635; rs1491850; rs1491851; rs1519479; rs1519480; rs16917204; rs16917234; rs16917271; rs16917274; rs17309874; rs17309930; rs2049045; rs2049047; rs2049048; rs2203877; rs2353512; rs3178739; rs3750934; rs4923463; rs6265; rs7102921; rs7124442; rs727155; rs7931247; rs7940188; rs8192466; rs908867; rs925946; rs925947; rs925948

# Macromolecular_Interacting_Partner_21_General_References:
2236018; 1889806; 1339267; 2025430; 8527932; 11214319; 7703225; 11152678; 10391209; 14566559

# Macromolecular_Interacting_Partner_21_References:
16939976; 16996500; 17006024; 17081696

# Macromolecular_Interacting_Partner_22_ID:
6559

# Macromolecular_Interacting_Partner_22_Name:
Mitogen-activated protein kinase 3

# Macromolecular_Interacting_Partner_22_Synonyms:
Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAPK 1; p44-ERK1; ERT2; p44-MAPK; Microtubule- associated protein 2 kinase

# Macromolecular_Interacting_Partner_22_Gene_Name:
MAPK3

# Macromolecular_Interacting_Partner_22_Protein_Sequence:
>Mitogenactivated protein kinase 3
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP

# Macromolecular_Interacting_Partner_22_Number_of_Residues:
379

# Macromolecular_Interacting_Partner_22_Molecular_Weight:
43136

# Macromolecular_Interacting_Partner_22_Theoretical_pI:
6.74

# Macromolecular_Interacting_Partner_22_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_22_General_Function:
Not Available

# Macromolecular_Interacting_Partner_22_Specific_Function:
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1

# Macromolecular_Interacting_Partner_22_Pathway:
Not Available

# Macromolecular_Interacting_Partner_22_Reaction:
Not Available

# Macromolecular_Interacting_Partner_22_Pfam_Domain_Function:
PF00069:Pkinase

# Macromolecular_Interacting_Partner_22_Signals:
None

# Macromolecular_Interacting_Partner_22_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_22_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_22_EC_Link:
EC 2.7.11.24

# Macromolecular_Interacting_Partner_22_GenBank_ID_Protein:
31221

# Macromolecular_Interacting_Partner_22_SwissProt_ID:
MK03_HUMAN (P27361)

# Macromolecular_Interacting_Partner_22_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_22_Genecard_id:
MAPK3

# Macromolecular_Interacting_Partner_22_Geneatlas_id:
MAPK3

# Macromolecular_Interacting_Partner_22_hgnc_id:
HGNC:6877

# Macromolecular_Interacting_Partner_22_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_22_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_22_Gene_Sequence:
>1140 bp
ATGGCGGCGGCGGCGGCTCAGGGGGGCGGGGGCGGGGAGCCCCGTAGAACCGAGGGGGTC
GGCCCGGGGGTCCCGGGGGAGGTGGAGATGGTGAAGGGGCAGCCGTTCGACGTGGGCCCG
CGCTACACGCAGTTGCAGTACATCGGCGAGGGCGCGTACGGCATGGTCAGCTCGGCCTAT
GACCACGTGCGCAAGACTCGCGTGGCCATCAAGAAGATCAGCCCCTTCGAACATCAGACC
TACTGCCAGCGCACGCTCCGGGAGATCCAGATCCTGCTGCGCTTCCGCCATGAGAATGTC
ATCGGCATCCGAGACATTCTGCGGGCGTCCACCCTGGAAGCCATGAGAGATGTCTACATT
GTGCAGGACCTGATGGAGACTGACCTGTACAAGTTGCTGAAAAGCCAGCAGCTGAGCAAT
GACCATATCTGCTACTTCCTCTACCAGATCCTGCGGGGCCTCAAGTACATCCACTCCGCC
AACGTGCTCCACCGAGATCTAAAGCCCTCCAACCTGCTCAGCAACACCACCTGCGACCTT
AAGATTTGTGATTTCGGCCTGGCCCGGATTGCCGATCCTGAGCATGACCACACCGGCTTC
CTGACGGAGTATGTGGCTACGCGCTGGTACCGGGCCCCAGAGATCATGCTGAACTCCAAG
GGCTATACCAAGTCCATCGACATCTGGTCTGTGGGCTGCATTCTGGCTGAGATGCTCTCT
AACCGGCCCATCTTCCCTGGCAAGCACTACCTGGATCAGCTCAACCACATTCTGGGCATC
CTGGGCTCCCCATCCCAGGAGGACCTGAATTGTATCATCAACATGAAGGCCCGAAACTAC
CTACAGTCTCTGCCCTCCAAGACCAAGGTGGCTTGGGCCAAGCTTTTCCCCAAGTCAGAC
TCCAAAGCCCTTGACCTGCTGGACCGGATGTTAACCTTTAACCCCAATAAACGGATCACA
GTGGAGGAAGCGCTGGCTCACCCCTACCTGGAGCAGTACTATGACCCGACGGATGAGCCA
GTGGCCGAGGAGCCCTTCACCTTCGCCATGGAGCTGGATGACCTACCTAAGGAGCGGCTG
AAGGAGCTCATCTTCCAGGAGACAGCACGCTTCCAGCCCGGAGTGCTGGAGGCCCCCTAG


# Macromolecular_Interacting_Partner_22_GenBank_ID_Gene:
X60188

# Macromolecular_Interacting_Partner_22_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_22_Locus:
16p11.2

# Macromolecular_Interacting_Partner_22_SNPs:
rs1143695; rs11865086; rs11864737; rs9921806; rs12922100; rs11863765; rs9930013; rs11546680; rs41292376; rs41291696; rs41280862; rs35691465; rs41280866; rs41280860; rs41280864; rs35666305; rs11644927; rs7199920; rs12918285; rs36084237; rs34799400; rs34564246; rs9940575; rs9940581; rs28529403; rs1042404; rs1062543; rs12924137; rs12930241; rs13569; rs1561414; rs2005219; rs3751867; rs7542; rs7698; rs8061772

# Macromolecular_Interacting_Partner_22_General_References:
7687743; 1540184; 1319925; 8794306

# Macromolecular_Interacting_Partner_22_References:
16643859; 16644915; 16697745; 16807266

# Macromolecular_Interacting_Partner_23_ID:
7007

# Macromolecular_Interacting_Partner_23_Name:
Phosphatidylinositol 3-kinase regulatory subunit alpha

# Macromolecular_Interacting_Partner_23_Synonyms:
PI3-kinase p85-subunit alpha; PtdIns-3-kinase p85-alpha; PI3K

# Macromolecular_Interacting_Partner_23_Gene_Name:
PIK3R1

# Macromolecular_Interacting_Partner_23_Protein_Sequence:
>Phosphatidylinositol 3kinase regulatory subunit alpha
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH
VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR

# Macromolecular_Interacting_Partner_23_Number_of_Residues:
724

# Macromolecular_Interacting_Partner_23_Molecular_Weight:
83599

# Macromolecular_Interacting_Partner_23_Theoretical_pI:
6.06

# Macromolecular_Interacting_Partner_23_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  lipid kinase activity
Function:  phosphoinositide 3-kinase activity
Function:  phosphatidylinositol 3-kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  guanyl nucleotide binding
Function:  GTP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  GTPase activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  protein complex
Component:  phosphoinositide 3-kinase complex

# Macromolecular_Interacting_Partner_23_General_Function:
Replication, recombination and repair 

# Macromolecular_Interacting_Partner_23_Specific_Function:
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues

# Macromolecular_Interacting_Partner_23_Pathway:
Not Available

# Macromolecular_Interacting_Partner_23_Reaction:
Not Available

# Macromolecular_Interacting_Partner_23_Pfam_Domain_Function:
PF00620:RhoGAP;
PF00017:SH2;
PF00018:SH3_1

# Macromolecular_Interacting_Partner_23_Signals:
None

# Macromolecular_Interacting_Partner_23_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_23_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_23_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_23_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_23_SwissProt_ID:
P85A_HUMAN (P27986)

# Macromolecular_Interacting_Partner_23_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_23_Genecard_id:
PIK3R1

# Macromolecular_Interacting_Partner_23_Geneatlas_id:
PIK3R1

# Macromolecular_Interacting_Partner_23_hgnc_id:
HGNC:8979

# Macromolecular_Interacting_Partner_23_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_23_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_23_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_23_GenBank_ID_Gene:
M61906

# Macromolecular_Interacting_Partner_23_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_23_Locus:
5q13.1

# Macromolecular_Interacting_Partner_23_SNPs:
rs3730089; rs706713; rs3730090; rs3729981; rs7722222; rs3756668; rs2888323; rs3729984; rs12755; rs7702655; rs1131951; rs1043526; rs1643544; rs4016109; rs831125; rs171649; rs706714; rs251408; rs34303; rs2112208; rs895304; rs251409; rs251404; rs251399; rs1010793; rs10063119; rs2302976; rs2302975; rs6893676; rs3730082; rs34309; rs6861401; rs7733084; rs1664577; rs34301; rs10065413; rs831229; rs6876003; rs2302974; rs4122269; rs831123; rs10940160; rs10515070; rs173702; rs831122; rs6881033; rs7714169; rs3730086; rs17317833; rs3730087; rs10515074; rs6860081; rs16897511; rs3730088; rs12657050; rs7713645; rs7709243; rs6890202; rs42849; rs251402; rs6863431; rs34308; rs3815701; rs706716; rs40318; rs831121; rs3730078; rs10072475; rs1862162; rs6890176; rs12652661; rs34306; rs10515073; rs1445760; rs863818; rs1974781; rs1823023; rs17318918; rs173703; rs12659907; rs13156223; rs2161120; rs10940159; rs16897561; rs16897601; rs1819987; rs12697060; rs7716675; rs34304; rs4976156; rs16897558; rs11746842; rs12656176; rs251406; rs972634; rs1550805; rs7725370; rs173704; rs17839411; rs6863799; rs3730092; rs3730084; rs1862161; rs251410; rs6449960; rs7707370; rs994221; rs862714; rs11957103; rs2121109; rs2431166; rs10940158; rs7709991; rs6894871; rs831124; rs8192680; rs16897570; rs10940161; rs3730073; rs251405; rs16897562; rs28365970; rs6868872; rs251401; rs16897509; rs8192679; rs1946207; rs13173003; rs2431167; rs3730077; rs34300; rs34307; rs7713756; rs2121108; rs13167294; rs16897620; rs251407; rs1946208; rs3730091; rs17852841; rs34175949; rs17847317; rs10583550; rs1664558; rs41268435; rs9687541; rs17253369; rs2545411; rs7708232; rs10669997; rs1043425; rs10070142; rs34570857; rs5868531; rs7707793; rs3729983; rs35243561; rs34491401; rs7712540; rs10612198; rs10612201; rs7712126; rs5868532; rs7712114; rs34870423; rs35033772; rs33943986; rs10612200; rs2591417; rs2544847; rs1043426; rs1664560; rs34873643; rs1643545; rs9687422; rs36055833; rs9687539; rs1103100; rs1643543; rs34422073; rs3729982; rs35767695; rs34248986; rs13188418; rs251400; rs35255745; rs11285010; rs34010696; rs35510423; rs7717745; rs10577524; rs10614002; rs2591418; rs13154156; rs1611062; rs35472540; rs34305; rs6872284; rs1643556; rs11335573; rs1055643; rs9918196; rs10580592; rs861245; rs35373278; rs185179; rs34302; rs1643933; rs1643917; rs35582171; rs33965010; rs34287; rs36212686; rs11313149; rs185180; rs5868527; rs10552908; rs35213868; rs11343765; rs10579213; rs35812956; rs3049952; rs34037377; rs34027260; rs11351105; rs36121518; rs34476787; rs34330183; rs2545410; rs35893424; rs11291585; rs1819986; rs35728943; rs16897559; rs13180447; rs7732540; rs13153101; rs35800397; rs1300127; rs11349259; rs11334943; rs6872004; rs35918993; rs11308179; rs6871851; rs6872296; rs7735204; rs34157100; rs10461539; rs2591419; rs34695203; rs10036950; rs11960604; rs10611201; rs12153457; rs35508629; rs36029081; rs10055629; rs3730085; rs1643916; rs34594637; rs35918259; rs251403; rs11451948; rs35705146; rs10552907; rs10698662; rs5868528; rs7735075; rs1055644; rs34893631; rs34174926; rs34793287; rs34058255; rs5868529; rs4317277; rs11351869; rs34044740; rs11360241; rs10571324; rs862716; rs11280364; rs3730079; rs10678795; rs35929649; rs5024999; rs33968242; rs5868530; rs34063898; rs13163961; rs40056; rs35286739; rs35946831; rs34282574; rs36123886; rs13170618; rs34824771; rs34833428; rs6872690; rs10940157; rs11749932; rs11750202; rs40419; rs411751; rs450006; rs6449959; rs6872765; rs6899219; rs695166; rs706710; rs706711; rs706712; rs7701498; rs7701952; rs7723804; rs7732637; rs831227; rs9291926; rs9291927

# Macromolecular_Interacting_Partner_23_General_References:
1849461; 8628286; 7541045; 9489702; 9687533; 12359715; 12009866; 8648629; 8599763; 8962058; 11567151; 7681364; 8961927; 8670861; 9032108; 10768093

# Macromolecular_Interacting_Partner_23_References:
16888186; 16902952; 17016431

# Macromolecular_Interacting_Partner_24_ID:
6486

# Macromolecular_Interacting_Partner_24_Name:
Mitogen-activated protein kinase 1

# Macromolecular_Interacting_Partner_24_Synonyms:
Extracellular signal-regulated kinase 2; ERK-2; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; p42-MAPK; ERT1

# Macromolecular_Interacting_Partner_24_Gene_Name:
MAPK1

# Macromolecular_Interacting_Partner_24_Protein_Sequence:
>Mitogenactivated protein kinase 1
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS


# Macromolecular_Interacting_Partner_24_Number_of_Residues:
360

# Macromolecular_Interacting_Partner_24_Molecular_Weight:
41390

# Macromolecular_Interacting_Partner_24_Theoretical_pI:
6.99

# Macromolecular_Interacting_Partner_24_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_24_General_Function:
Not Available

# Macromolecular_Interacting_Partner_24_Specific_Function:
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1

# Macromolecular_Interacting_Partner_24_Pathway:
Not Available

# Macromolecular_Interacting_Partner_24_Reaction:
Not Available

# Macromolecular_Interacting_Partner_24_Pfam_Domain_Function:
PF00069:Pkinase

# Macromolecular_Interacting_Partner_24_Signals:
None

# Macromolecular_Interacting_Partner_24_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_24_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_24_EC_Link:
EC 2.7.11.24

# Macromolecular_Interacting_Partner_24_GenBank_ID_Protein:
182191

# Macromolecular_Interacting_Partner_24_SwissProt_ID:
MK01_HUMAN (P28482)

# Macromolecular_Interacting_Partner_24_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_24_Genecard_id:
MAPK1

# Macromolecular_Interacting_Partner_24_Geneatlas_id:
MAPK1

# Macromolecular_Interacting_Partner_24_hgnc_id:
HGNC:6871

# Macromolecular_Interacting_Partner_24_PDB_ID:
4ERK

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_24_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_24_Gene_Sequence:
>1083 bp
ATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGAC
GTGGGGCCGCGCTACACCAACCTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGC
TCTGCTTATGATAATGTCAACAAAGTTCGAGTAGCTATCAAGAAAATCAGCCCCTTTGAG
CACCAGACCTACTGCCAGAGAACCCTGAGGGAGATAAAAATCTTACTGCGCTTCAGACAT
GAGAACATCATTGGAATCAATGACATTATTCGAGCACCAACCATCGAGCAAATGAAAGAT
GTATATATAGTACAGGACCTCATGGAAACAGATCTTTACAAGCTCTTGAAGACACAACAC
CTCAGCAATGACCATATCTGCTATTTTCTCTACCAGATCCTCAGAGGGTTAAAATATATC
CATTCAGCTAACGTTCTGCACCGTGACCTCAAGCCTTCCAACCTGCTGCTCAACACCACC
TGTGATCTCAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCAC
ACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTG
AATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAA
ATGCTTTCCAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAATCACATT
TTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCT
AGGAACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCA
AATGCTGACTCCAAAGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAG
AGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGT
GACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAG
GAAAAGCTAAAAGAACTAATTTTTGAAGAGACTGCTAGATTCCAGCCAGGATACAGATCT
TAA

# Macromolecular_Interacting_Partner_24_GenBank_ID_Gene:
M84489

# Macromolecular_Interacting_Partner_24_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_24_Locus:
22q11.2|22q11.21

# Macromolecular_Interacting_Partner_24_SNPs:
rs1803545; rs3729910; rs6928; rs13943; rs5755074; rs743411; rs3810610; rs17759598; rs2266965; rs2276008; rs2298432; rs1063311; rs9340; rs13515; rs2266966; rs7292198; rs8138018; rs17821423; rs13058; rs2298434; rs2283792; rs2266969; rs743409; rs6518986; rs5749998; rs5755694; rs6518951; rs1892847; rs2266967; rs2283793; rs5999521; rs5755745; rs8141851; rs4821402; rs5999752; rs6518997; rs3788332; rs5750113; rs11912710; rs9607287; rs2276010; rs2283791; rs5999515; rs9607298; rs1892848; rs11912377; rs2283795; rs9610470; rs7292302; rs8141815; rs9610355; rs2283796; rs4821263; rs9610375; rs11704205; rs4821401; rs17213172; rs5999614; rs8136867; rs4821371; rs7284924; rs2266968; rs1892846; rs4821367; rs5755579; rs2070505; rs8139215; rs5755099; rs5999842; rs9610338; rs3827303; rs5749939; rs2154944; rs17759796; rs7290469; rs7286558; rs2876981; rs8135916; rs2283794; rs5751273; rs6518968; rs2006893; rs5999749; rs5999550; rs8136902; rs11704117; rs3729914; rs4821336; rs5755654; rs11703350; rs11913721; rs17820162; rs8142455; rs12159146; rs7285387; rs9610374; rs7510592; rs9680623; rs5749984; rs9607285; rs8136405; rs11704433; rs11704847; rs9607274; rs2096687; rs17213286; rs5999704; rs11703678; rs9610496; rs9610500; rs11913453; rs7290932; rs11704597; rs13053945; rs5999750; rs11089745; rs4821337; rs2329881; rs5749937; rs1557288; rs4640486; rs5999452; rs5749986; rs9610371; rs10222287; rs3729912; rs9610315; rs4821339; rs11705173; rs4516540; rs8135386; rs9610458; rs9680622; rs2027656; rs9610417; rs13055356; rs7292924; rs9610400; rs12172554; rs9610324; rs12628258; rs17821572; rs9610487; rs8140233; rs5999823; rs1557287; rs17004026; rs9607272; rs17003502; rs11913063; rs8136590; rs17821500; rs9607286; rs2276005; rs9607340; rs3810609; rs2276006; rs9610271; rs3810608; rs1048748; rs35401654; rs1130164; rs3188781; rs41282607; rs34573886; rs3810611; rs12158121; rs35774216; rs35450537; rs1048752; rs35268998; rs2276007; rs34155605; rs34338438; rs35097784; rs11704800; rs9607264; rs7292584; rs34478799; rs1803546; rs12168996; rs35926036; rs35419717; rs34746140; rs3891788; rs5999532; rs5999787; rs11913120; rs7289300; rs28727550; rs9610323; rs34349809; rs34637918; rs5999793; rs12167814; rs11704381; rs35051857; rs11703242; rs8141026; rs11462556; rs5755664; rs11273917; rs13053225; rs11414253; rs5755376; rs35061420; rs33953967; rs35881327; rs2186545; rs36122515; rs5995102; rs11393133; rs28780784; rs10598132; rs28862404; rs28373639; rs10222258; rs12373966; rs5999653; rs12159151; rs11390969; rs34007644; rs35825500; rs13058633; rs13055533; rs13056289; rs11267198; rs34347426; rs34196957; rs9610446; rs35225688; rs28370372; rs7285926; rs3949122; rs9624360; rs12484706; rs28704920; rs13058223; rs4821369; rs5999460; rs2298433; rs9712854; rs11303516; rs35736049; rs5749967; rs9610341; rs12628210; rs5999822; rs34042646; rs35604132; rs8142827; rs35276275; rs35913408; rs34915608; rs11705262; rs35967578; rs35791287; rs34033501; rs7286970; rs11426902; rs34817343; rs13054553; rs28513891; rs5755240; rs35418579; rs34412833; rs9610317; rs9610504; rs9610414; rs9607330; rs5995052; rs9712903; rs2008611; rs35950684; rs9610286; rs4478016; rs34544205; rs9610481; rs35001275; rs5999799; rs5999484; rs13056532; rs13056790; rs11405543; rs12169154; rs12163200; rs33914475; rs4050958; rs35723944; rs36031460; rs35843533; rs8136165; rs28720995; rs34842862; rs35399662; rs8141500; rs34987537; rs13057484; rs34644063; rs36123701; rs5999869; rs13054793; rs28763889; rs11385908; rs5755141; rs34431893; rs13055420; rs34550586; rs7284903; rs35676446; rs34145288; rs3052710; rs10663958; rs5755389; rs28803281; rs7284305; rs9680639; rs5755151; rs5999502; rs9623462; rs5999785; rs3052739; rs5999791; rs12159799; rs9610294; rs9610454; rs5844472; rs13058418; rs3729913; rs9610367; rs7289846; rs10599826; rs35444904; rs35220860; rs13056791; rs2329882; rs8140010; rs33986273; rs36087626; rs9610314; rs13056005; rs34522282; rs12158504; rs33922907; rs35578418; rs10641589; rs13057392; rs12172215; rs9622287; rs11360402; rs11490038; rs9607313; rs35389108; rs8142650; rs35096158; rs4050957; rs5755611; rs8136204; rs12172360; rs5999792; rs28566555; rs35248177; rs9607283; rs9622201; rs36031695; rs35318935; rs34416472; rs10714076; rs5999525; rs35644012; rs11277747; rs3729909; rs11703624; rs12170038; rs5755237; rs11089747; rs34534734; rs9610328; rs35907379; rs35585950; rs9607329; rs3841771; rs9680638; rs28697123; rs9607320; rs11352870; rs9610459; rs10598131; rs9610386; rs9610368; rs35593415; rs33932545; rs11272759; rs13058216; rs10664466; rs9622385; rs9622169; rs5999877; rs5999880; rs36042810; rs9610505; rs9607343; rs35549484; rs11914029; rs12157534; rs12160084; rs12167593; rs12627782; rs17759568; rs2876980; rs3810606; rs5749806; rs5749811; rs5754968; rs5754971; rs5755040; rs5999335; rs5999891; rs8139376; rs9607241

# Macromolecular_Interacting_Partner_24_General_References:
1540184; 1319925; 12665801; 8794306

# Macromolecular_Interacting_Partner_24_References:
16870702; 16957308

# Macromolecular_Interacting_Partner_25_ID:
6681

# Macromolecular_Interacting_Partner_25_Name:
RAC-alpha serine/threonine-protein kinase

# Macromolecular_Interacting_Partner_25_Synonyms:
RAC-PK-alpha; Protein kinase B; PKB; C-AKT

# Macromolecular_Interacting_Partner_25_Gene_Name:
AKT1

# Macromolecular_Interacting_Partner_25_Protein_Sequence:
>RACalpha serine/threonineprotein kinase
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA


# Macromolecular_Interacting_Partner_25_Number_of_Residues:
480

# Macromolecular_Interacting_Partner_25_Molecular_Weight:
55687

# Macromolecular_Interacting_Partner_25_Theoretical_pI:
5.96

# Macromolecular_Interacting_Partner_25_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_25_General_Function:
Not Available

# Macromolecular_Interacting_Partner_25_Specific_Function:
General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis, partly by playing a role in both insulin-induced phosphorylation of 4E-BP1 and in insulin-induced activation of p70 S6 kinase. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase

# Macromolecular_Interacting_Partner_25_Pathway:
Not Available

# Macromolecular_Interacting_Partner_25_Reaction:
Not Available

# Macromolecular_Interacting_Partner_25_Pfam_Domain_Function:
PF00169:PH;
PF00069:Pkinase;
PF00433:Pkinase_C

# Macromolecular_Interacting_Partner_25_Signals:
None

# Macromolecular_Interacting_Partner_25_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_25_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_25_EC_Link:
EC 2.7.11.1

# Macromolecular_Interacting_Partner_25_GenBank_ID_Protein:
190828

# Macromolecular_Interacting_Partner_25_SwissProt_ID:
AKT1_HUMAN (P31749)

# Macromolecular_Interacting_Partner_25_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_25_Genecard_id:
AKT1

# Macromolecular_Interacting_Partner_25_Geneatlas_id:
AKT1

# Macromolecular_Interacting_Partner_25_hgnc_id:
HGNC:391

# Macromolecular_Interacting_Partner_25_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_25_Subcellular_Location:
Cytoplasm. Nucleus. Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1)

# Macromolecular_Interacting_Partner_25_Gene_Sequence:
>1443 bp
ATGAGCGACGTGGCTATTGTGAAGGAGGGTTGGCTGCACAAACGAGGGGAGTACATCAAG
ACCTGGCGGCCACGCTACTTCCTCCTCAAGAATGATGGCACCTTCATTGGCTACAAGGAG
CGGCCGCAGGATGTGGACCAACGTGAGGCTCCCCTCAACAACTTCTCTGTGGCGCAGTGC
CAGCTGATGAAGACGGAGCGGCCCCGGCCCAACACCTTCATCATCCGCTGCCTGCAGTGG
ACCACTGTCATCGAACGCACCTTCCATGTGGAGACTCCTGAGGAGCGGGAGGAGTGGACA
ACCGCCATCCAGACTGTGGCTGACGGCCTCAAGAAGCAGGAGGAGGAGGAGATGGACTTC
CGGTCGGGCTCACCCAGTGACAACTCAGGGGCTGAAGAGATGGAGGTGTCCCTGGCCAAG
CCCAAGCACCGCGTGACCATGAACGAGTTTGAGTACCTGAAGCTGCTGGGCAAGGGCACT
TTCGGCAAGGTGATCCTGGTGAAGGAGAAGGCCACAGGCCGCTACTACGCCATGAAGATC
CTCAAGAAGGAAGTCATCGTGGCCAAGGACGAGGTGGCCCACACACTCACCGAGAACCGC
GTCCTGCAGAACTCCAGGCACCCCTTCCTCACAGCCCTGAAGTACTCTTTCCAGACCCAC
GACCGCCTCTGCTTTGTCATGGAGTACGCCAACGGGGGCGAGCTGTTCTTCCACCTGTCC
CGGGAACGTGTGTTCTCCGAGGACCGGGCCCGCTTCTATGGCGCTGAGATTGTGTCAGCC
CTGGACTACCTGCACTCGGAGAAGAACGTGGTGTACCGGGACCTCAAGCTGGAGAACCTC
ATGCTGGACAAGGACGGGCACATTAAGATCACAGACTTCGGGCTGTGCAAGGAGGGGATC
AAGGACGGTGCCACCATGAAGACCTTTTGCGGCACACCTGAGTACCTGGCCCCCGAGGTG
CTGGAGGACAATGACTACGGCCGTGCAGTGGACTGGTGGGGGCTGGGCGTGGTCATGTAC
GAGATGATGTGCGGTCGCCTGCCCTTCTACAACCAGGACCATGAGAAGCTTTTTGAGCTC
ATCCTCATGGAGGAGATCCGCTTCCCGCGCACGCTTGGTCCCGAGGCCAAGTCCTTGCTT
TCAGGGCTGCTCAAGAAGGACCCCAAGCAGAGGCTTGGCGGGGGCTCCGAGGACGCCAAG
GAGATCATGCAGCATCGCTTCTTTGCCGGTATCGTGTGGCAGCACGTGTACGAGAAGAAG
CTCAGCCCACCCTTCAAGCCCCAGGTCACGTCGGAGACTGACACCAGGTATTTTGATGAG
GAGTTCACGGCCCAGATGATCACCATCACACCACCTGACCAAGATGACAGCATGGAGTGT
GTGGACAGCGAGCGCAGGCCCCACTTCCCCCAGTTCTCCTACTCGGCCAGCAGCACGGCC
TGA

# Macromolecular_Interacting_Partner_25_GenBank_ID_Gene:
M63167

# Macromolecular_Interacting_Partner_25_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_25_Locus:
14q32.32|14q32.32

# Macromolecular_Interacting_Partner_25_SNPs:
rs1130233; rs2230506; rs2230508; rs1130214; rs28634999; rs35416681; rs34558581; rs3803305; rs36214921; rs1130245; rs34757714; rs34790457; rs34865723; rs10144641; rs10138227; rs2494735; rs2494732; rs2494738; rs4375597; rs2494743; rs2494731; rs2494742; rs3730329; rs11849304; rs3730344; rs3001371; rs2494746; rs2498789; rs10149779; rs2494748; rs7140735; rs2498796; rs3803304; rs3730362; rs2494741; rs11848899; rs3730358; rs3730368; rs12588965; rs2494739; rs3730328; rs6576060; rs2494737; rs34410130; rs2498791; rs2494749; rs11848695; rs3730330; rs10136000; rs2494740; rs35635404; rs2498793; rs34664585; rs12432267; rs35622471; rs10142069; rs11848805; rs17846832; rs2498797; rs12436999; rs2498788; rs36214559; rs2494744; rs2498794; rs3730346; rs3730361; rs36214558; rs12437017; rs35314414; rs35586636; rs2498802; rs2494750; rs2494751; rs2498786; rs2498801; rs2494752; rs11555433; rs34409589; rs11555435; rs11555436; rs12881616; rs11555431; rs11555432; rs11555434; rs17846825; rs34670300; rs17846831; rs17846828; rs3840005; rs17102385; rs11555428; rs17846829; rs11555430; rs11555429; rs17846821; rs17846826; rs34830023; rs41307094; rs1130443; rs3001372; rs1130295; rs11391511; rs1130526; rs1804268; rs3002448; rs28730786; rs35285446; rs5811151; rs3730360; rs28535133; rs5811153; rs2498800; rs2498792; rs2494734; rs36214560; rs33931844; rs2498795; rs35707077; rs2494745; rs35858243; rs3730342; rs11382683; rs5811152; rs12433614; rs34907636; rs10149034; rs35478693; rs4076736; rs3002451; rs7143802; rs35641875; rs36214556; rs36214914; rs5811154; rs35288747; rs33938935; rs36214916; rs17846818; rs34530493; rs34326349; rs36214562; rs11847866; rs35939172; rs12590657; rs34782376; rs35330545; rs2494733; rs17846822; rs11851662; rs36214915; rs2494736; rs34119321; rs2498798; rs28379051; rs6145483; rs8192700; rs36214557; rs2498787; rs34402148; rs3730345; rs2494747; rs17846816; rs34449645; rs10141765; rs3730348; rs17846812; rs12897418; rs33970580; rs7160999; rs5811155; rs34391967; rs28546406; rs10141867; rs14905; rs2498784; rs2498785; rs2498804; rs33925946; rs34284721; rs3803299; rs3803300; rs4132468; rs4145854; rs4983387; rs7151243; rs9989156

# Macromolecular_Interacting_Partner_25_General_References:
1851997; 11508278; 1718748; 1533586; 9736715; 8978681; 11994271; 12149249

# Macromolecular_Interacting_Partner_25_References:
16710359; 16839743; 16977260; 17016431

# Macromolecular_Interacting_Partner_26_ID:
6263

# Macromolecular_Interacting_Partner_26_Name:
Prostaglandin G/H synthase 2 precursor

# Macromolecular_Interacting_Partner_26_Synonyms:
Cyclooxygenase- 2; COX-2; Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; PHS II

# Macromolecular_Interacting_Partner_26_Gene_Name:
PTGS2

# Macromolecular_Interacting_Partner_26_Protein_Sequence:
>Prostaglandin G/H synthase 2 precursor
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPT
PNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNAD
YGYKSWEAFSNLSYYTRALPP
VPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQ
GSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGL
GHGVDLNHIYGETLARQRKLRLFKDGK
MKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGL
VPGLMMYATIWLREHN
RVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPE
LLFNK
QFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQ
IAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMS
AELEALYGDIDAVELY
PALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKP
STFGGEVGFQIINTASIQSLICNNVKG
CPFTSFSVPDPELIKTVTINASSSRSGLDDIN
PTVLLKERSTEL

# Macromolecular_Interacting_Partner_26_Number_of_Residues:
604

# Macromolecular_Interacting_Partner_26_Molecular_Weight:
68997

# Macromolecular_Interacting_Partner_26_Theoretical_pI:
7.41

# Macromolecular_Interacting_Partner_26_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_26_General_Function:
Not Available

# Macromolecular_Interacting_Partner_26_Specific_Function:
May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity

# Macromolecular_Interacting_Partner_26_Pathway:
map00590  Prostaglandin and leukotriene metabolism

# Macromolecular_Interacting_Partner_26_Reaction:
arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

# Macromolecular_Interacting_Partner_26_Pfam_Domain_Function:
PF03098:An_peroxidase;
PF00008:EGF

# Macromolecular_Interacting_Partner_26_Signals:
1-17

# Macromolecular_Interacting_Partner_26_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_26_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_26_EC_Link:
EC 1.14.99.1

# Macromolecular_Interacting_Partner_26_GenBank_ID_Protein:
291988

# Macromolecular_Interacting_Partner_26_SwissProt_ID:
PGH2_HUMAN (P35354)

# Macromolecular_Interacting_Partner_26_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_26_Genecard_id:
PTGS2

# Macromolecular_Interacting_Partner_26_Geneatlas_id:
PTGS2

# Macromolecular_Interacting_Partner_26_hgnc_id:
HGNC:9605

# Macromolecular_Interacting_Partner_26_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_26_Subcellular_Location:
Microsome; microsomal membrane; peripheral membrane protein

# Macromolecular_Interacting_Partner_26_Gene_Sequence:
>1815 bp

ATGCTCGCCCGCGCCCTGCTGCTGTGCGCGGTCCTGGCGCTCAGCCATACAGCAAATCC
TTGCTGTTCCC
ACCCATGTCAAAACCGAGGTGTATGTATGAGTGTGGGATTTGACCAGT
ATAAGTGCGATTGTACCCGGAC
AGGATTCTATGGAGAAAACTGCTCAACACCGGAATTT
TTGACAAGAATAAAATTATTTCTGAAACCCACT
CCAAACACAGTGCACTACATACTTAC
CCACTTCAAGGGATTTTGGAACGTTGTGAATAACATTCCCTTCC
TTCGAAATGCAATTA
TGAGTTATGTGTTGACATCCAGATCACATTTGATTGACAGTCCACCAACTTACAA
TGCT
GACTATGGCTACAAAAGCTGGGAAGCCTTCTCTAACCTCTCCTATTATACTAGAGCCCTT
CCTCCT
GTGCCTGATGATTGCCCGACTCCCTTGGGTGTCAAAGGTAAAAAGCAGCTTCC
TGATTCAAATGAGATTG
TGGAAAAATTGCTTCTAAGAAGAAAGTTCATCCCTGATCCCC
AGGGCTCAAACATGATGTTTGCATTCTT
TGCCCAGCACTTCACGCATCAGTTTTTCAAG
ACAGATCATAAGCGAGGGCCAGCTTTCACCAACGGGCTG
GGCCATGGGGTGGACTTAAA
TCATATTTACGGTGAAACTCTGGCTAGACAGCGTAAACTGCGCCTTTTCA
AGGATGGAA
AAATGAAATATCAGATAATTGATGGAGAGATGTATCCTCCCACAGTCAAAGATACTCAGG
C
AGAGATGATCTACCCTCCTCAAGTCCCTGAGCATCTACGGTTTGCTGTGGGGCAGGAG
GTCTTTGGTCTG
GTGCCTGGTCTGATGATGTATGCCACAATCTGGCTGCGGGAACACAA
CAGAGTATGCGATGTGCTTAAAC
AGGAGCATCCTGAATGGGGTGATGAGCAGTTGTTCC
AGACAAGCAGGCTAATACTGATAGGAGAGACTAT
TAAGATTGTGATTGAAGATTATGTG
CAACACTTGAGTGGCTATCACTTCAAACTGAAATTTGACCCAGAA
CTACTTTTCAACAA
ACAATTCCAGTACCAAAATCGTATTGCTGCTGAATTTAACACCCTCTATCACTGGC
ATC
CCCTTCTGCCTGACACCTTTCAAATTCATGACCAGAAATACAACTATCAACAGTTTATCT
ACAACAA
CTCTATATTGCTGGAACATGGAATTACCCAGTTTGTTGAATCATTCACCAGG
CAAATTGCTGGCAGGGTT
GCTGGTGGTAGGAATGTTCCACCCGCAGTACAGAAAGTATC
ACAGGCTTCCACTGACCAGAGCAGGCAGA
TGAAATACCAGTCTTTTAATGAGTACCGCA
AACGCTTTATGCTGAAGCCCTATGAATCATTTGAAGAACT
TACAGGAGAAAAGGAAATG
TCTGCAGAGTTGGAAGCACTCTATGGTGACATCGATGCTGTGGAGCTGTAT
CCTGCCCT
TCTGGTAGAAAAGCCTCGGCCAGATGCCATCTTTGGTGAAACCATGGTAGAAGTTGGAGC
AC
CATTCTCCTTGAAAGGACTTATGGGTAATGTTATATGTTCTCCTGCCTACTGGAAGC
CAAGCACTTTTGG
TGGAGAAGTGGGTTTTCAAATCATCAACACTGCCTCAATTCAGTCT
CTCATCTGCAATAACGTGAAGGGC
TGTCCCTTTACTTCATTCAGTGTTCCAGATCCAGA
GCTCATTAAAACAGTCACCATCAATGCAAGTTCTT
CCCGCTCCGGACTAGATGATATCA
ATCCCACAGTACTACTAAAAGAACGTTCGACTGAACTGTAG

# Macromolecular_Interacting_Partner_26_GenBank_ID_Gene:
L15326

# Macromolecular_Interacting_Partner_26_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_26_Locus:
1q25.2-q25.3

# Macromolecular_Interacting_Partner_26_SNPs:
rs3218622; rs5272; rs5273; rs3218625; rs5279; rs5277; rs5278; rs5274; rs3218623; rs20429; rs4648265; rs5276; rs5275; rs2206593; rs4648292; rs689469; rs5271; rs3835508; rs689467; rs689470; rs689468; rs4648257; rs4648303; rs1051897; rs4648300; rs4648290; rs1051896; rs4648297; rs4648302; rs4648296; rs20432; rs2066826; rs4648268; rs4648287; rs20427; rs4648283; rs4648274; rs4648273; rs4648278; rs20430; rs4648284; rs20428; rs4648272; rs11567821; rs4648276; rs4648282; rs4648261; rs2745557; rs2066824; rs4648285; rs4648267; rs2066823; rs4648263; rs16825748; rs3218626; rs4648277; rs11567827; rs11567834; rs4648280; rs20434; rs2066822; rs4648271; rs4648262; rs4648258; rs16825745; rs20433; rs20424; rs4648306; rs20419; rs4648307; rs20415; rs4648308; rs689466; rs689465; rs20418; rs5270; rs4648251; rs4648256; rs4648304; rs4648310; rs20417; rs4648250; rs3918304; rs4648311; rs689462; rs20423; rs20420; rs2734779; rs11567815; rs11567831; rs11567814; rs4648309; rs20416; rs4648305; rs4648254; rs20426; rs4648279; rs4648264; rs4648288; rs3218624; rs3179567; rs4648295; rs36233646; rs3134592; rs3134591; rs4648299; rs4648298; rs13306032; rs11384450; rs11567830; rs13306038; rs3134589; rs13306033; rs2853804; rs3134590; rs2853805; rs11567829; rs11567819; rs4648289; rs4648301; rs13306035; rs34888870; rs4648294; rs13306031; rs4648293; rs2853803; rs4987012; rs12759220; rs11567822; rs4648260; rs4648269; rs11567826; rs13306034; rs4648259; rs11567820; rs4648266; rs11567825; rs4648281; rs11567824; rs11567823; rs4648286; rs4648270; rs4322189; rs35440347; rs11567835; rs689463; rs4648253; rs2223626; rs11567832; rs689464; rs20421; rs4648252; rs2745558; rs34901173; rs4648255; rs11567833; rs20422; rs11567837; rs11567836; rs12027712; rs10649972; rs10911902; rs10911905; rs10911907; rs10911908; rs1119064; rs1119065; rs11583191; rs12042763; rs12064238; rs12124257; rs12749248; rs2143416; rs2143417; rs2179555; rs2383515; rs2734776; rs2734777; rs2745559; rs4422959; rs6684912

# Macromolecular_Interacting_Partner_26_General_References:
8473346; 1380156; 8181472; 7945196

# Macromolecular_Interacting_Partner_26_References:
16672767; 16687473; 16754782

# Macromolecular_Interacting_Partner_27_ID:
7663

# Macromolecular_Interacting_Partner_27_Name:
Signal transducer and activator of transcription 3

# Macromolecular_Interacting_Partner_27_Synonyms:
Acute-phase response factor

# Macromolecular_Interacting_Partner_27_Gene_Name:
STAT3

# Macromolecular_Interacting_Partner_27_Protein_Sequence:
>Signal transducer and activator of transcription 3
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM

# Macromolecular_Interacting_Partner_27_Number_of_Residues:
770

# Macromolecular_Interacting_Partner_27_Molecular_Weight:
88069

# Macromolecular_Interacting_Partner_27_Theoretical_pI:
6.23

# Macromolecular_Interacting_Partner_27_GO_Classification:
>>>
Function:  signal transducer activity
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_27_General_Function:
Not Available

# Macromolecular_Interacting_Partner_27_Specific_Function:
Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA

# Macromolecular_Interacting_Partner_27_Pathway:
Not Available

# Macromolecular_Interacting_Partner_27_Reaction:
Not Available

# Macromolecular_Interacting_Partner_27_Pfam_Domain_Function:
PF00017:SH2;
PF01017:STAT_alpha;
PF02864:STAT_bind;
PF02865:STAT_int

# Macromolecular_Interacting_Partner_27_Signals:
None

# Macromolecular_Interacting_Partner_27_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_27_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_27_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_27_GenBank_ID_Protein:
475789

# Macromolecular_Interacting_Partner_27_SwissProt_ID:
STAT3_HUMAN (P40763)

# Macromolecular_Interacting_Partner_27_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_27_Genecard_id:
STAT3

# Macromolecular_Interacting_Partner_27_Geneatlas_id:
STAT3

# Macromolecular_Interacting_Partner_27_hgnc_id:
HGNC:11364

# Macromolecular_Interacting_Partner_27_PDB_ID:
1BG1

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_27_Subcellular_Location:
Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation

# Macromolecular_Interacting_Partner_27_Gene_Sequence:
>2313 bp
ATGGCCCAATGGAATCAGCTACAGCAGCTTGACACACGGTACCTGGAGCAGCTCCATCAG
CTCTACAGTGACAGCTTCCCAATGGAGCTGCGGCAGTTTCTGGCCCCTTGGATTGAGAGT
CAAGATTGGGCATATGCGGCCAGCAAAGAATCACATGCCACTTTGGTGTTTCATAATCTC
CTGGGAGAGATTGACCAGCAGTATAGCCGCTTCCTGCAAGAGTCGAATGTTCTCTATCAG
CACAATCTACGAAGAATCAAGCAGTTTCTTCAGAGCAGGTATCTTGAGAAGCCAATGGAG
ATTGCCCGGATTGTGGCCCGGTGCCTGTGGGAAGAATCACGCCTTCTACAGACTGCAGCC
ACTGCGGCCCAGCAAGGGGGCCAGGCCAACCACCCCACAGCAGCCGTGGTGACGGAGAAG
CAGCAGATGCTGGAGCAGCACCTTCAGGATGTCCGGAAGAGAGTGCAGGATCTAGAACAG
AAAATGAAAGTGGTAGAGAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTCAAG
AGTCAAGGAGACATGCAAGATCTGAATGGAAACAACCAGTCAGTGACCAGGCAGAAGATG
CAGCAGCTGGAACAGATGCTCACTGCGCTGGACCAGATGCGGAGAAGCATCGTGAGTGAG
CTGGCGGGGCTTTTGTCAGCGATGGAGTACGTGCAGAAAACTCTCACGGACGAGGAGCTG
GCTGACTGGAAGAGGCGGCAACAGATTGCCTGCATTGGAGGCCCGCCCAACATCTGCCTA
GATCGGCTAGAAAACTGGATAACGTCATTAGCAGAATCTCAACTTCAGACCCGTCAACAA
ATTAAGAAACTGGAGGAGTTGCACCAAAAAGTTTCCTACAAAGGGGACCCCATTGTACAG
CACCGGCCGATGCTGGAGGAGAGGATCGTGGAGCTGTTCAGAAACTTAATGAAAAGTGCC
TTTGTGGTGGAGCGGCAGCCCTGCATGCCCATGCATCCTGACCGGCCCCTCGTCATCAAG
ACCGGCGTCCAGTTCACTACTAAAGTCAGGTTGCTGGTCAAGTTCCCTGAGTTGAATTAT
CAGCTTAAAATTAAAGTGTGCATTGACAAAGACTCTGGGGACGTTGCAGCTCTCAGAGGA
TCCCGGAAATTTAACATTCTGGGCACAAACACAAAAGTGATGAACATGGAAGAATCCAAC
AACGGCAGCCTCTCTGCAGAATTCAAACACTTGACCCTGAGGGAGCAGAGATGTGGGAAT
GGGGGCCGAGCCAATTGTGATGCTTCCCTGATTGTGACTGAGGAGCTGCACCTGATCACC
TTTGAGACCGAGGTGTATCACCAAGGTCTCAAGATTGACCTAGAGACCCACTCCTTGTCA
GTTGTGGTGATCTCCAACATCTGTCAGATGCCAAATGCCTGGGCGTCCATCCTGTGGTAC
AACATGCTGACCAACAATCCCAAGAATGTGAACTTCTTCACTAAGCCGCCAATTGGAACC
TGGGACCAAGTGGCCGAGGTGCTCAGCTGGCAGTTCTCGTCCACCACCAAGCGGGGGCTG
AGCATCGAGCAGCTGACAACGCTGGCTGAGAAGCTCCTAGGGCCTGGTGTGAACTACTCA
GGGTGTCAGATCACATGGGCTAACTTCTGCAAAGAAAACATGGCTGGCAAGGGCTTCTCC
TACTGGGTCTGGCTAGACAATATCATCGACCTTGTGAAAAAGTATATCTTGGCCCTTTGG
AATGAAGGGTACATCATGGGTTTCATCAGCAAGGAGCGGGAGCGGGCCATCTTGAGCACT
AAGCCCCCAGGCACCTTCCTGCTGCGCTTCAGTGAAAGCAGCAAAGAAGGAGGCGTCACT
TTCACTTGGGTGGAGAAGGACATCAGCGGTAAGACCCAGATCCAGTCCGTGGAACCATAC
ACAAAGCAGCAGCTGAACAACATGTCATTTGCTGAAATCATCATGGGCTATAAGATCATG
GATGCTACCAATATCCTGTTGTCTCCACTTGTCTATCTCTATCCTGACATTCCCAAGGAG
GAGGCATTCGGGAAGTATTGTCGGCCAGAGAGCCAGGAGCATCCTGAAGCTGACCCAGGT
AGCGCTGCCCCATACCTGAAGACCAAGTTTATCTGTGTGACACCAACGACCTGCAGCAAT
ACCATTGACCTGCCGATGTCCCCCCGCGCTTTAGATTCATTGATGCAGTTTGGAAATAAT
GGTGAAGGTGCTGAACCCTCAGCAGGAGGGCAGTTTGAGTCCCTCACCTTTGACATGGAG
TTGACCTCGGAGTGCGCTACCTCCCCCATGTGA

# Macromolecular_Interacting_Partner_27_GenBank_ID_Gene:
L29277

# Macromolecular_Interacting_Partner_27_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_27_Locus:
17q21.31

# Macromolecular_Interacting_Partner_27_SNPs:
rs1064116; rs17882069; rs17880940; rs1064113; rs1905340; rs957970; rs1053005; rs744166; rs957971; rs1053004; rs1026916; rs4796792; rs9912773; rs1053023; rs8073836; rs6503697; rs4796791; rs9891119; rs12949918; rs8068748; rs9891867; rs7224416; rs11079042; rs7219059; rs4287619; rs3785898; rs16967719; rs8074288; rs8073517; rs1905341; rs13342031; rs7219739; rs17882369; rs7224007; rs7211777; rs4103200; rs12602466; rs3744483; rs3883338; rs9913597; rs11867382; rs8070763; rs17881668; rs17879497; rs12602449; rs7216516; rs17878746; rs17881438; rs7211264; rs6503698; rs9303328; rs9895473; rs17887094; rs17881805; rs17881664; rs8071537; rs17884307; rs17885629; rs12937642; rs8076051; rs17884090; rs17879207; rs17883506; rs12942547; rs17882436; rs12947808; rs7214610; rs1963988; rs17884541; rs8066517; rs17593222; rs17883029; rs3736164; rs11869886; rs4796646; rs17885278; rs9898794; rs1963987; rs2306580; rs8072566; rs6503696; rs2306581; rs9898884; rs8072391; rs2293152; rs9889396; rs3809758; rs7206960; rs9890635; rs8069645; rs8081431; rs7214964; rs7215104; rs8066464; rs9909659; rs8075442; rs6503695; rs9915916; rs9896889; rs7216201; rs7501954; rs8081037; rs7206950; rs8064496; rs10153241; rs8074524; rs9890802; rs3816769; rs3869550; rs17881940; rs3736161; rs12721576; rs7217655; rs3869549; rs7213632; rs16967689; rs4265875; rs7220550; rs17880900; rs17881621; rs12601611; rs7224339; rs7213633; rs12721583; rs17882163; rs17887066; rs17885291; rs7215694; rs8078731; rs2291281; rs17879752; rs17878412; rs17879738; rs17881759; rs17884478; rs1222187; rs17880538; rs17880983; rs17886724; rs17885350; rs17878930; rs17879287; rs17878696; rs17882516; rs17879962; rs8080551; rs11870967; rs17885431; rs17882334; rs17878674; rs17887068; rs17884929; rs17885741; rs12103893; rs2291282; rs17886496; rs17880347; rs3736162; rs17881032; rs17879513; rs17882035; rs17886256; rs17882406; rs17881320; rs17879198; rs17881938; rs8069836; rs17879459; rs4796793; rs16967725; rs17405722; rs17885036; rs17884075; rs909056; rs17880962; rs17878478; rs1141129; rs11547455; rs1064110; rs1803125; rs34460718; rs1064122; rs1064111; rs1064117; rs1141145; rs1141118; rs1064115; rs1141121; rs1141122; rs1141119; rs1064121; rs1064118; rs1064112; rs1141120; rs1064114; rs1141117; rs1141123; rs1064119; rs1064120; rs1141131; rs1141144; rs1141111; rs35342182; rs1222186; rs4796644; rs8075676; rs12938189; rs17883843; rs17881974; rs34393906; rs11449147; rs34788284; rs35901220; rs11408644; rs10659012; rs34354144; rs12938193; rs1803126; rs11871210; rs34115235; rs34263131; rs12953155; rs34094936; rs7211035; rs17880712; rs34972443; rs9897389; rs41289087; rs3736163; rs12946759; rs7214139; rs34003618; rs12938463; rs12951192; rs12936225; rs7207492; rs11408645; rs35729990; rs11408950; rs16967716; rs35427318; rs12951971; rs11457025; rs35840966; rs10775; rs7350890; rs12949179; rs17883295; rs35585589; rs8064997; rs34479652; rs4519378; rs12942611; rs11328125; rs35561964; rs1231903; rs35314169; rs8071969; rs1236315; rs35987545; rs17883814; rs12952630; rs35896270; rs11378560; rs12603457; rs12325774; rs17886670; rs3169702; rs34291674; rs12946874; rs35857074; rs7221074; rs11379691; rs11440924; rs35099574; rs12938461; rs11444177; rs12452182; rs11398324; rs11339093; rs10706301; rs17884918; rs34559610; rs12945333; rs8069115; rs17881859; rs17880808; rs34054293; rs35398041; rs35950888; rs17884714; rs34923201; rs17879250; rs17879442; rs35184581; rs34165663; rs11657309; rs17880904; rs17879681; rs8066904; rs17884716; rs17880663; rs35863777; rs17878909; rs1312364; rs34846688; rs11656164; rs9909736; rs12950549; rs17883005; rs17886263; rs17885843; rs8077296; rs8081156; rs7221636; rs34330322; rs17882635; rs36055143; rs12946502; rs8064327; rs35159711; rs17882551; rs35455295; rs11318541; rs11285572; rs35499754; rs10706259; rs17884756; rs17879448; rs3830585; rs8072736; rs35162488; rs17878464; rs17879201; rs12943176; rs17884004; rs35432758; rs10657713; rs11392125; rs35885311; rs744284; rs17882079; rs33997807; rs35332755; rs1057935; rs11079043; rs1135669; rs1135670; rs11658772; rs12601982; rs16967738; rs17320971; rs2067694; rs2272087; rs2293154; rs2293155; rs3198502; rs4621023; rs9889942; rs9906989; rs9915299

# Macromolecular_Interacting_Partner_27_General_References:
7512451; 9630560; 7701321; 12208879; 12023369

# Macromolecular_Interacting_Partner_27_References:
16709613; 16806201

# Macromolecular_Interacting_Partner_28_ID:
7673

# Macromolecular_Interacting_Partner_28_Name:
Stromal cell-derived factor 1 precursor

# Macromolecular_Interacting_Partner_28_Synonyms:
SDF-1; CXCL12; Pre-B cell growth-stimulating factor; PBSF; hIRH[Contains: SDF-1-beta(3-72; SDF-1-alpha(3-67]

# Macromolecular_Interacting_Partner_28_Gene_Name:
CXCL12

# Macromolecular_Interacting_Partner_28_Protein_Sequence:
>Stromal cellderived factor 1 precursor
MNAKVVVVLVLVLTALCLSDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIV
ARLKNNNRQVCIDPKLKWIQEYLEKALNKRFKM

# Macromolecular_Interacting_Partner_28_Number_of_Residues:
93

# Macromolecular_Interacting_Partner_28_Molecular_Weight:
10666

# Macromolecular_Interacting_Partner_28_Theoretical_pI:
10.54

# Macromolecular_Interacting_Partner_28_GO_Classification:
>>>
Function:  chemokine activity
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_28_General_Function:
Not Available

# Macromolecular_Interacting_Partner_28_Specific_Function:
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites

# Macromolecular_Interacting_Partner_28_Pathway:
Not Available

# Macromolecular_Interacting_Partner_28_Reaction:
Not Available

# Macromolecular_Interacting_Partner_28_Pfam_Domain_Function:
PF00048:IL8

# Macromolecular_Interacting_Partner_28_Signals:
1-21

# Macromolecular_Interacting_Partner_28_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_28_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_28_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_28_GenBank_ID_Protein:
571508

# Macromolecular_Interacting_Partner_28_SwissProt_ID:
SDF1_HUMAN (P48061)

# Macromolecular_Interacting_Partner_28_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_28_Genecard_id:
CXCL12

# Macromolecular_Interacting_Partner_28_Geneatlas_id:
CXCL12

# Macromolecular_Interacting_Partner_28_hgnc_id:
HGNC:10672

# Macromolecular_Interacting_Partner_28_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_28_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_28_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_28_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_28_Gene_Sequence:
>282 bp
ATGAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTGCCTCAGCGAC
GGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTCGAAAGCCATGTTGCC
AGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCAAACTGTGCCCTTCAGATTGTA
GCCCGGCTGAAGAACAACAACAGACAAGTGTGCATTGACCCGAAGCTAAAGTGGATTCAG
GAGTACCTGGAGAAAGCTTTAAACAAGAGGTTCAAGATGTGA

# Macromolecular_Interacting_Partner_28_GenBank_ID_Gene:
U16752

# Macromolecular_Interacting_Partner_28_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_28_Locus:
10q11.1

# Macromolecular_Interacting_Partner_28_SNPs:
rs1804429; rs1029153; rs1804430; rs266092; rs3740085; rs10900031; rs2522; rs266093; rs1801157; rs169097; rs2839695; rs2839696; rs1065297; rs17883887; rs17883369; rs12258838; rs17881685; rs2839694; rs17156233; rs17881297; rs17882538; rs17884600; rs17886257; rs17886066; rs1023265; rs3780890; rs2297630; rs4948880; rs7093481; rs2839690; rs1889402; rs17883825; rs2297631; rs266089; rs2236534; rs266091; rs266085; rs2839692; rs266087; rs7092453; rs12413068; rs7088876; rs10793537; rs2760669; rs4948879; rs4948878; rs2236533; rs1889401; rs197452; rs11592974; rs11594377; rs10793538; rs3780891; rs12357238; rs17881729; rs17878782; rs1144471; rs17883187; rs17884185; rs17881813; rs11239026; rs2297629; rs2839689; rs17882849; rs266088; rs17880192; rs266086; rs2839688; rs17880066; rs2839691; rs17883610; rs17887234; rs10900033; rs17880863; rs17885932; rs17880358; rs17886624; rs17878725; rs17881412; rs17879548; rs11239024; rs2839693; rs266090; rs17881575; rs17881284; rs17881068; rs17880793; rs17885289; rs266094; rs17880777; rs17156215; rs10900030; rs17880313; rs2839685; rs11239027; rs17879529; rs17156283; rs2839682; rs17880411; rs17880068; rs17885696; rs2839684; rs17156287; rs11239021; rs17883339; rs2839683; rs2839687; rs2839686; rs11239020; rs266095; rs11541200; rs41307557; rs17880170; rs7777; rs17881604; rs41473651; rs41384348; rs17884204; rs17886187; rs36063399; rs1804428; rs41301589; rs34983612; rs17883573; rs41459848; rs10347; rs34952911; rs17883898; rs1804571; rs17883113; rs17883916; rs2483770; rs17881772; rs17883967; rs17540437; rs36112451; rs2489240; rs17883700; rs17879134; rs11239025; rs34836687; rs17886201; rs17886784; rs7073133; rs34927719; rs34246951; rs17540465; rs9326514; rs17886196; rs1060664; rs17881591; rs17884144; rs17885644; rs36232162; rs12246037; rs11239023; rs17883102; rs17540492; rs17156293; rs2489239; rs34602583; rs36232160; rs17880325; rs36232163; rs36232466; rs36231842; rs17883587; rs34430213; rs12355907; rs35144079; rs17880129; rs34340138; rs36232465; rs28475098; rs17884027; rs10900029; rs1108537; rs11239011; rs11239016; rs11239017; rs11239018; rs11239019; rs11239031; rs1147872; rs11595588; rs11818543; rs1413519; rs17156191; rs17156193; rs17391002; rs17482472; rs185545; rs1855531; rs266096; rs266098; rs266099; rs266100; rs266101; rs266102; rs266103; rs266104; rs266105; rs2781551; rs2839679; rs2839680; rs2839681; rs2861441; rs2861442; rs4948876; rs4948877; rs635518; rs635902; rs7085182; rs7088285; rs728142; rs728143; rs754617; rs754618; rs7915848; rs7918568

# Macromolecular_Interacting_Partner_28_General_References:
7490086; 9384579; 9618518

# Macromolecular_Interacting_Partner_28_References:
16819765; 17077300; 17115901

# Macromolecular_Interacting_Partner_29_ID:
6829

# Macromolecular_Interacting_Partner_29_Name:
Mitogen-activated protein kinase 10

# Macromolecular_Interacting_Partner_29_Synonyms:
Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3; MAP kinase p49 3F12

# Macromolecular_Interacting_Partner_29_Gene_Name:
MAPK10

# Macromolecular_Interacting_Partner_29_Protein_Sequence:
>Mitogenactivated protein kinase 10
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR

# Macromolecular_Interacting_Partner_29_Number_of_Residues:
464

# Macromolecular_Interacting_Partner_29_Molecular_Weight:
52586

# Macromolecular_Interacting_Partner_29_Theoretical_pI:
6.78

# Macromolecular_Interacting_Partner_29_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_29_General_Function:
Not Available

# Macromolecular_Interacting_Partner_29_Specific_Function:
Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity

# Macromolecular_Interacting_Partner_29_Pathway:
Not Available

# Macromolecular_Interacting_Partner_29_Reaction:
Not Available

# Macromolecular_Interacting_Partner_29_Pfam_Domain_Function:
PF00069:Pkinase

# Macromolecular_Interacting_Partner_29_Signals:
None

# Macromolecular_Interacting_Partner_29_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_29_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_29_EC_Link:
EC 2.7.11.24

# Macromolecular_Interacting_Partner_29_GenBank_ID_Protein:
468151

# Macromolecular_Interacting_Partner_29_SwissProt_ID:
MK10_HUMAN (P53779)

# Macromolecular_Interacting_Partner_29_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_29_Genecard_id:
MAPK10

# Macromolecular_Interacting_Partner_29_Geneatlas_id:
MAPK10

# Macromolecular_Interacting_Partner_29_hgnc_id:
HGNC:6872

# Macromolecular_Interacting_Partner_29_PDB_ID:
1JNK

# Macromolecular_Interacting_Partner_29_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_29_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_29_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_29_Gene_Sequence:
>1269 bp
ATGAGCCTCCATTTCTTATACTACTGCAGTGAACCAACATTGGATGTGAAAATTGCCTTT
TGTCAGGGATTCGATAAACAAGTGGATGTGTCATATATTGCCAAACATTACAACATGAGC
AAAAGCAAAGTTGACAACCAGTTCTACAGTGTGGAAGTGGGAGACTCAACCTTCACAGTT
CTCAAGCGCTACCAGAATCTAAAGCCTATTGGCTCTGGGGCTCAGGGCATAGTTTGTGCC
GCGTATGATGCTGTCCTTGACAGAAATGTGGCCATTAAGAAGCTCAGCAGACCCTTTCAG
AACCAAACACATGCCAAGAGAGCGTACCGGGAGCTGGTCCTCATGAAGTGTGTGAACCAT
AAAAACATTATTAGTTTATTAAATGTCTTCACACCCCAGAAAACGCTGGAGGAGTTCCAA
GATGTTTACTTAGTAATGGAACTGATGGATGCCAACTTATGTCAAGTGATTCAGATGGAA
TTAGACCATGAGCGAATGTCTTACCTGCTGTACCAAATGTTGTGTGGCATTAAGCACCTC
CATTCTGCTGGAATTATTCACAGGGATTTAAAACCAAGTAACATTGTAGTCAAGTCTGAT
TGCACATTGAAAATCCTGGACTTTGGACTGGCCAGGACAGCAGGCACAAGCTTCATGATG
ACTCCATATGTGGTGACACGTTATTACAGAGCCCCTGAGGTCATCCTGGGGATGGGCTAC
AAGGAGAACGTGGATATATGGTCTGTGGGATGCATTATGGGAGAAATGGTTCGCCACAAA
ATCCTCTTTCCAGGAAGGGACTATATTGACCAGTGGAATAAGGTAATTGAACAACTAGGA
ACACCATGTCCAGAATTCATGAAGAAATTGCAACCCACAGTAAGAAACTATGTGGAGAAT
CGGCCCAAGTATGCGGGACTCACCTTCCCCAAACTCTTCCCAGATTCCCTCTTCCCAGCG
GACTCCGAGCACAATAAACTCAAAGCCAGCCAAGCCAGGGACTTGTTGTCAAAGATGCTA
GTGATTGACCCAGCAAAAAGAATATCAGTGGACGACGCCTTACAGCATCCCTACATCAAC
GTCTGGTATGACCCAGCCGAAGTGGAGGCGCCTCCACCTCAGATATATGACAAGCAGTTG
GATGAAAGAGAACACACAATTGAAGAATGGAAAGAACTTATCTACAAGGAAGTAATGAAT
TCAGAAGAAAAGACTAAAAATGGTGTAGTAAAAGGACAGCCTTCTCCTTCAGCACAGGTG
CAGCAGTGA

# Macromolecular_Interacting_Partner_29_GenBank_ID_Gene:
U07620

# Macromolecular_Interacting_Partner_29_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_29_Locus:
4q22.1-q23

# Macromolecular_Interacting_Partner_29_SNPs:
rs1460763; rs1460767; rs1031738; rs2869444; rs1460759; rs2199308; rs1460769; rs2199309; rs1108429; rs2904101; rs1031737; rs2869438; rs2869421; rs1460756; rs1460753; rs2290882; rs4611890; rs10008238; rs7670728; rs11097100; rs6810895; rs10010011; rs6825707; rs10029339; rs4693145; rs4693142; rs1903360; rs11097104; rs11097099; rs7655217; rs1599313; rs6531910; rs12499006; rs1460760; rs10213453; rs7349681; rs6531906; rs6855169; rs7694034; rs7666454; rs12650052; rs12505566; rs12512375; rs6531914; rs6825506; rs7699555; rs11932806; rs7687771; rs11943376; rs6810839; rs9884127; rs12507758; rs1460751; rs10004539; rs6531925; rs4132490; rs6817452; rs2904094; rs4385018; rs1903361; rs6858306; rs12641387; rs12509960; rs1031739; rs3926499; rs12498980; rs2869424; rs1460758; rs1460766; rs6829923; rs10021706; rs6531913; rs4693135; rs6531921; rs4235080; rs2904095; rs1599314; rs10213444; rs6531909; rs4693139; rs6839160; rs1460750; rs6845742; rs9999403; rs6531926; rs6531924; rs6531916; rs6852305; rs2290881; rs12646571; rs11097109; rs11938088; rs9990599; rs11736313; rs1460752; rs7654796; rs4608765; rs12505959; rs6832259; rs7666231; rs1460757; rs6829870; rs2904097; rs6811046; rs10856859; rs6531911; rs9307018; rs2904090; rs2869437; rs6531905; rs6828947; rs7678480; rs9994931; rs12513293; rs958; rs12513374; rs4235079; rs7680934; rs4693765; rs12648265; rs10010952; rs2904096; rs2199307; rs4597789; rs7669060; rs12511071; rs6823664; rs2869435; rs10011429; rs11939109; rs6531923; rs7656914; rs6844365; rs6531907; rs6827698; rs11097103; rs11097110; rs10213451; rs7665868; rs12505595; rs6845605; rs12640395; rs2869431; rs1460761; rs4693766; rs6531915; rs7695155; rs12512698; rs7667999; rs7690384; rs11946235; rs10516768; rs7669487; rs2869436; rs12507513; rs7684258; rs12505532; rs17451111; rs1466380; rs17409925; rs6825521; rs1460754; rs17253274; rs12505336; rs7694920; rs6826702; rs2904099; rs7684081; rs11930495; rs13115429; rs6822338; rs11941150; rs7674849; rs6531922; rs2869432; rs13115172; rs12508545; rs6531918; rs2035056; rs12503051; rs11097107; rs6851183; rs17011890; rs7695707; rs7688633; rs12508801; rs11097108; rs11941484; rs4114893; rs7699065; rs7669675; rs6531927; rs2904105; rs2869433; rs7677400; rs12646021; rs11929810; rs13129883; rs13146797; rs11929779; rs12498923; rs6821819; rs11726269; rs11942064; rs12513237; rs10516771; rs4693763; rs13111170; rs11097098; rs12511667; rs12640392; rs7699047; rs17011519; rs6842671; rs17449485; rs11947870; rs6531928; rs7684469; rs13104178; rs10516774; rs12508939; rs7683561; rs6852494; rs6531917; rs17417318; rs6851604; rs7657056; rs13132206; rs6844363; rs7699333; rs13138286; rs11944466; rs12501551; rs17409687; rs1380922; rs9654156; rs12510302; rs11929783; rs17011893; rs11935211; rs17011645; rs11946258; rs9997633; rs17011756; rs12645370; rs7685419; rs4488910; rs6829766; rs7668374; rs4693143; rs17011584; rs7688651; rs2126021; rs6856688; rs12508372; rs11725943; rs12505800; rs6531912; rs4693140; rs12511114; rs7684518; rs17011445; rs7683909; rs10516773; rs10003259; rs10516770; rs2035057; rs17409311; rs10030319; rs7655797; rs12502371; rs12508579; rs11097102; rs2904102; rs2869439; rs12508286; rs7678392; rs10026060; rs12644920; rs7678691; rs10516769; rs11932102; rs9654157; rs13130598; rs1599312; rs4693144; rs6844343; rs7691626; rs7699105; rs12500132; rs10034428; rs17449015; rs7440491; rs7656010; rs2869422; rs11737795; rs6849834; rs12510373; rs4613534; rs4389539; rs17011705; rs922195; rs17011617; rs12513122; rs6531904; rs12513353; rs1460755; rs7685683; rs10516772; rs2904093; rs7698274; rs10022904; rs4693141; rs11097106; rs12504127; rs7437117; rs12500543; rs9307016; rs4693761; rs16996040; rs12501743; rs17418062; rs17011654; rs7684570; rs7679269; rs6827098; rs12504929; rs13146802; rs17011479; rs17011870; rs17011564; rs4693764; rs11726550; rs17011659; rs7696982; rs12649297; rs17011402; rs4693137; rs17011489; rs10016847; rs11725624; rs6830872; rs17011568; rs17415651; rs17011516; rs7684758; rs17450224; rs7677251; rs12500319; rs6814005; rs17011467; rs6847300; rs12646076; rs17452273; rs17011913; rs3733367; rs17011621; rs10035072; rs7689808; rs1380923; rs769378; rs6853248; rs9715454; rs10019269; rs17011457; rs7687046; rs6827405; rs2869423; rs1841427; rs6843457; rs11097101; rs11943324; rs9762809; rs17409527; rs17449147; rs10010751; rs1460762; rs10009161; rs12504532; rs17011731; rs6836561; rs17011611; rs17011847; rs10025305; rs7687161; rs12651511; rs17011653; rs7696980; rs17011419; rs7661197; rs7663388; rs6827483; rs10028202; rs6826762; rs6816691; rs9762806; rs17011588; rs17011421; rs17011575; rs12331353; rs7687972; rs12505443; rs7693923; rs6832461; rs17011396; rs17011409; rs7662140; rs6851072; rs4449380; rs12499209; rs17011458; rs10030225; rs17011492; rs9997175; rs12511602; rs17011592; rs17011547; rs11943129; rs2869430; rs17011630; rs1841426; rs10031237; rs17418221; rs17409478; rs12509902; rs11931871; rs17011649; rs6831576; rs12507860; rs17011487; rs769377; rs9762814; rs17011843; rs17417758; rs17408832; rs17011623; rs12503520; rs6847482; rs10034589; rs17011472; rs7696316; rs12640131; rs7654907; rs17011607; rs17011400; rs1903362; rs17011460; rs12508926; rs6818726; rs1460765; rs4521313; rs13112020; rs12509769; rs17011577; rs17409637; rs17011875; rs10026338; rs12646706; rs10470881; rs17449582; rs7691172; rs13140626; rs12502087; rs17011410; rs11935348; rs6841973; rs12506828; rs6829684; rs12498902; rs7661679; rs17011397; rs11097105; rs7676652; rs17011432; rs3762915; rs17011590; rs17011459; rs11947620; rs13110630; rs10006563; rs17011551; rs6811435; rs7663763; rs1318492; rs6531908; rs1903363; rs6842530; rs17011526; rs7663773; rs6813859; rs6817640; rs10019871; rs10030197; rs17408881; rs12500023; rs6831589; rs7682129; rs17011803; rs12511499; rs7697017; rs7661809; rs6813724; rs9994380; rs7690323; rs17011537; rs4371581; rs17011522; rs4693753; rs17451306; rs10006000; rs1460764; rs13112340; rs1460749; rs17011533; rs10003756; rs17011428; rs12511135; rs9996693; rs7698396; rs6845334; rs6824346; rs17011556; rs2904100; rs10213302; rs17409904; rs17011821; rs17011407; rs6826951; rs17011655; rs7667204; rs13115030; rs4299551; rs13140948; rs17011573; rs2035058; rs17011540; rs2009855; rs6847635; rs12500076; rs9994303; rs2589506; rs1436527; rs2589514; rs1436524; rs1469869; rs1436521; rs2589518; rs1541998; rs2282596; rs1946733; rs6822478; rs7435363; rs4403040; rs4693754; rs10004712; rs4235078; rs1898248; rs12502902; rs4546235; rs3775187; rs4352468; rs4334746; rs4613557; rs10028075; rs2118044; rs2282598; rs10031752; rs6531898; rs1436529; rs4501213; rs3775169; rs4377581; rs4482754; rs4364253; rs6821745; rs12647176; rs10024003; rs4407492; rs12639693; rs10001480; rs9307015; rs6856450; rs3775166; rs9884282; rs3775184; rs7692508; rs6810413; rs4133139; rs11929863; rs4487330; rs12642887; rs4693757; rs6854208; rs3775181; rs9995879; rs6848433; rs12650286; rs2282597; rs3775168; rs6815306; rs3775182; rs7692460; rs12640230; rs3775164; rs10212744; rs4530621; rs3775183; rs11097091; rs2575673; rs17011341; rs10009993; rs12644947; rs3775170; rs4414944; rs13103374; rs9307014; rs12647506; rs12502934; rs1469870; rs7670470; rs10003556; rs4446299; rs13112959; rs2575672; rs3775173; rs1436522; rs9884770; rs3775180; rs4351013; rs7692676; rs10033283; rs3775167; rs10212952; rs11097094; rs6531897; rs2043649; rs1010778; rs10020650; rs3775171; rs10011390; rs1002484; rs6531892; rs746438; rs4693136; rs7684198; rs11934691; rs7689936; rs3775176; rs17011324; rs6842186; rs10027764; rs4414943; rs7670786; rs4499692; rs7696878; rs6822410; rs10516763; rs7670681; rs13142206; rs12644938; rs10023731; rs3822036; rs3775175; rs11733961; rs11097092; rs17008675; rs2043650; rs6531893; rs12643642; rs7659520; rs12648064; rs10001162; rs9684602; rs17011322; rs5004884; rs12642872; rs17011339; rs17011349; rs10006261; rs2043648; rs4382028; rs7691896; rs6855234; rs9760017; rs10034271; rs1561154; rs10018678; rs4693756; rs10025882; rs6811151; rs10002407; rs2282599; rs10776485; rs4560400; rs4522858; rs10009942; rs3775185; rs7654005; rs3755971; rs1898249; rs3822037; rs13114632; rs6531891; rs6846365; rs9996208; rs6854511; rs7697197; rs7686599; rs17011355; rs6840318; rs13103861; rs13121113; rs5006575; rs12512583; rs2282595; rs7439672; rs12648171; rs11934127; rs2575674; rs7699978; rs2589515; rs1201; rs2575675; rs1202; rs2589516; rs12512524; rs17011312; rs10032602; rs17011314; rs7660160; rs28760360; rs34414912; rs17450827; rs34255377; rs35547091; rs34168022; rs17011766; rs4458422; rs28536101; rs34262586; rs35517015; rs35294861; rs35501076; rs4608763; rs6849947; rs4129300; rs11435039; rs4269144; rs5860021; rs7436985; rs10534985; rs28896887; rs35116135; rs1115229; rs35217429; rs10671229; rs17416927; rs28839895; rs3527; rs7661648; rs17450910; rs13140380; rs35435792; rs34369854; rs17011858; rs34455560; rs9968336; rs35140130; rs3029315; rs35842829; rs12498558; rs7442188; rs28489900; rs28804774; rs28834688; rs7695670; rs35882077; rs35610513; rs34648043; rs34904465; rs6815085; rs28830848; rs17011643; rs34442411; rs35257599; rs35178184; rs11943866; rs34265383; rs28421956; rs4693769; rs17011682; rs34328856; rs35085432; rs35034762; rs7691277; rs33970548; rs35338513; rs35581530; rs11278816; rs34061649; rs34304791; rs35461035; rs13124817; rs34743167; rs35892134; rs7376405; rs17409269; rs11330422; rs35492319; rs36216983; rs17011720; rs13113317; rs10539886; rs13149041; rs6839310; rs28733919; rs17011696; rs34683010; rs10608638; rs4561895; rs4994993; rs36228436; rs7679167; rs28520822; rs28695505; rs34809402; rs34253891; rs34870954; rs28463620; rs28670086; rs28722990; rs7675381; rs9307017; rs34885616; rs17011700; rs28534721; rs34954949; rs35572072; rs34989577; rs35859687; rs35240319; rs10600798; rs35991788; rs4618275; rs35774265; rs13124872; rs11947890; rs28450091; rs9998205; rs33949420; rs3030118; rs35450214; rs3030160; rs12644976; rs13126246; rs6850992; rs35900214; rs33991102; rs34241060; rs28373627; rs34593390; rs28661214; rs7697335; rs34125064; rs35130751; rs35441446; rs6844636; rs35767206; rs35145865; rs13126021; rs13113315; rs6836359; rs35826931; rs7690940; rs28408117; rs9654155; rs35063332; rs34696102; rs17011690; rs6856862; rs33929180; rs7673423; rs35083678; rs35343868; rs12644859; rs36021595; rs2001612; rs10681488; rs28791572; rs13145464; rs13113328; rs35965801; rs34448816; rs5860022; rs28694187; rs28890938; rs34498673; rs28536743; rs10545105; rs9761579; rs12500128; rs13116387; rs35427609; rs10016000; rs28434311; rs10591715; rs28705770; rs3971920; rs7672563; rs3217717; rs28821771; rs35079757; rs12650508; rs3030142; rs13129988; rs3029313; rs7688495; rs34505400; rs10714569; rs35097345; rs12643272; rs34201683; rs17417827; rs35609863; rs10014678; rs28427030; rs34111505; rs11944190; rs34111165; rs36223042; rs2219590; rs34184989; rs13140549; rs2169232; rs9994347; rs36076697; rs34790740; rs28870188; rs34783569; rs10639041; rs1460768; rs34676161; rs28626971; rs35003006; rs35334656; rs5860019; rs34911547; rs13124881; rs5860023; rs4434210; rs10711609; rs35968542; rs34447604; rs35808523; rs2869434; rs11728235; rs10716571; rs17011853; rs36004445; rs13118244; rs34637756; rs28613556; rs34024985; rs11284646; rs10538760; rs34570949; rs35129937; rs34800738; rs35795436; rs13112890; rs10639042; rs34816270; rs34609132; rs35817774; rs34547847; rs9761874; rs28515691; rs11439209; rs6531899; rs28416998; rs35412018; rs33976873; rs35103650; rs35022866; rs17011806; rs36124809; rs11730779; rs34575399; rs11942108; rs28847910; rs35757767; rs28406787; rs34973055; rs34192441; rs35160765; rs3030124; rs28702698; rs34721708; rs2007976; rs28803851; rs35324025; rs35888867; rs7437697; rs13132706; rs28664010; rs34477595; rs34503531; rs28755839; rs6844802; rs6853290; rs4693762; rs34748597; rs4349565; rs17011815; rs35573944; rs35122643; rs4450887; rs33935168; rs33945648; rs28830922; rs13145461; rs3030114; rs28734891; rs11097095; rs10550573; rs13124525; rs35907363; rs28444287; rs34243707; rs6831733; rs13148508; rs28722583; rs35977040; rs28759971; rs35108904; rs34854999; rs34863847; rs13116803; rs13126094; rs10708095; rs6836163; rs4575960; rs35272630; rs10549069; rs9998829; rs28559713; rs4608764; rs13113779; rs12501090; rs34163860; rs17011764; rs6850605; rs4132491; rs35788198; rs34332756; rs35118208; rs7677406; rs35867435; rs35288754; rs34210154; rs34914334; rs36211477; rs28411373; rs36078401; rs10020888; rs34364808; rs28404815; rs35161743; rs28803213; rs13140707; rs35212998; rs36184857; rs7675359; rs11458660; rs28630852; rs17011897; rs35173052; rs28816476; rs35031715; rs9715449; rs34743978; rs17011767; rs17011845; rs17011819; rs12650517; rs5860024; rs34063796; rs34805580; rs34544666; rs35455450; rs34043435; rs13136303; rs35816063; rs11460057; rs36057902; rs10020889; rs35443953; rs13434575; rs11097096; rs13140740; rs11404211; rs36023771; rs34608518; rs34467283; rs6810953; rs36041399; rs35960605; rs34388593; rs35240246; rs28425193; rs17011774; rs3030110; rs35952969; rs11734792; rs17011872; rs11339874; rs36092105; rs35696959; rs17011708; rs28583812; rs28722082; rs13117193; rs34440566; rs35443845; rs6844573; rs11931070; rs34404446; rs35565125; rs34624037; rs11722341; rs17409562; rs11941923; rs7442324; rs10642552; rs35087395; rs10639063; rs28812808; rs13140361; rs35463589; rs35199525; rs28433471; rs8180149; rs28572764; rs28826941; rs28792132; rs2035055; rs13136895; rs28849082; rs4994992; rs34215628; rs13124639; rs11944647; rs34238796; rs13145457; rs34601352; rs28411372; rs13126019; rs5860025; rs9714693; rs35869982; rs11932859; rs7699144; rs10012013; rs34470194; rs13147005; rs11097097; rs13112497; rs34486987; rs34813710; rs36101511; rs6814123; rs34135924; rs34034936; rs11936320; rs28783973; rs12331772; rs28529458; rs34328097; rs13134099; rs13120126; rs33935094; rs10538012; rs6856365; rs17011354; rs17405567; rs7681267; rs34159031; rs35755826; rs6856155; rs35865395; rs28514916; rs9760243; rs10027225; rs1436523; rs1987599; rs35218486; rs5860017; rs13111648; rs3836594; rs10856856; rs34899473; rs28552906; rs3775186; rs35404583; rs41457050; rs28399149; rs34537730; rs5860013; rs35663996; rs34749448; rs34122764; rs36212057; rs7681951; rs34850141; rs13148731; rs34756998; rs13104555; rs35660849; rs35588497; rs34998174; rs35833770; rs34581941; rs4289439; rs7692668; rs34476895; rs5022021; rs13125713; rs28578870; rs34929575; rs36216172; rs12503688; rs4572869; rs28485608; rs34729900; rs4479697; rs34807837; rs34836858; rs4693755; rs34074833; rs34494584; rs34641637; rs13125729; rs11447293; rs4305506; rs34490730; rs13110593; rs36051698; rs28602213; rs17011338; rs5860016; rs33967580; rs28564356; rs35529605; rs6833404; rs13137708; rs33915987; rs28886577; rs733245; rs35534226; rs35394196; rs34038586; rs34324822; rs11413469; rs34699430; rs34770162; rs28538268; rs28516651; rs34050480; rs35076380; rs11360333; rs34741254; rs5860012; rs10538907; rs13104186; rs4345173; rs3841985; rs34825310; rs5860015; rs35211423; rs7667297; rs13353771; rs6823292; rs6813473; rs6531890; rs36085847; rs34949899; rs3775174; rs3822035; rs28660296; rs10635481; rs35495063; rs34886510; rs13146800; rs28895314; rs35606170; rs28709251; rs13104858; rs6818736; rs28435171; rs35225779; rs28576440; rs34300479; rs33962451; rs4419471; rs36047555; rs35893712; rs35915959; rs6813767; rs28398988; rs993593; rs11464313; rs34890849; rs28538338; rs35985560; rs35971482; rs983362; rs6821840; rs35438921; rs13434461; rs35278948; rs28754957; rs35080222; rs35280239; rs35466444; rs34937342; rs7667730; rs35320793; rs36047328; rs4382027; rs35279016; rs34751931; rs1436525; rs34439623; rs34952784; rs35891526; rs35823399; rs28409011; rs33977029; rs34155854; rs5860011; rs5860014; rs11721577; rs6531896; rs28846216; rs34180438; rs35107154; rs11432370; rs28594219; rs35490865; rs35333179; rs41279295; rs13138031; rs6825701; rs34158309; rs33990825; rs11309220; rs34791873; rs35136227; rs36132996; rs2060588; rs28639372; rs35568742; rs1436526; rs36133086; rs33951909; rs28756326; rs35187473; rs41282389; rs6857877; rs6843159; rs34188118; rs34534392; rs33979648; rs34789840; rs35273363; rs6816545; rs34498081; rs35358194; rs28865277; rs28562760; rs34934309; rs34060265; rs3775172; rs9762665; rs34562438; rs28625279; rs34725089; rs13104097; rs34757256; rs28642002; rs35270911; rs28684379; rs7681273; rs35485855; rs35867054; rs28360921; rs34134501; rs28394598; rs34008671; rs35473638; rs34307500; rs35112097; rs7660151; rs10034578; rs17011284; rs17011286; rs17011297; rs17011308; rs1946734; rs2164535; rs2575676; rs2589509; rs2589523; rs2589525; rs3755970; rs4640664; rs7438872; rs7439032; rs7677101

# Macromolecular_Interacting_Partner_29_General_References:
7826642; 8654373; 10715136; 9739089

# Macromolecular_Interacting_Partner_29_References:
16854387

# Macromolecular_Interacting_Partner_30_ID:
7120

# Macromolecular_Interacting_Partner_30_Name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit precursor

# Macromolecular_Interacting_Partner_30_Synonyms:
G gamma-I

# Macromolecular_Interacting_Partner_30_Gene_Name:
GNG2

# Macromolecular_Interacting_Partner_30_Protein_Sequence:
>Guanine nucleotidebinding protein GI/GS/GO gamma2 subunit precursor
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
FREKKFFCAIL

# Macromolecular_Interacting_Partner_30_Number_of_Residues:
71

# Macromolecular_Interacting_Partner_30_Molecular_Weight:
7850

# Macromolecular_Interacting_Partner_30_Theoretical_pI:
8.22

# Macromolecular_Interacting_Partner_30_GO_Classification:
>>>
Function:  signal transducer activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  extrinsic to membrane
Component:  extrinsic to plasma membrane
Component:  heterotrimeric G-protein complex

# Macromolecular_Interacting_Partner_30_General_Function:
Not Available

# Macromolecular_Interacting_Partner_30_Specific_Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction

# Macromolecular_Interacting_Partner_30_Pathway:
Not Available

# Macromolecular_Interacting_Partner_30_Reaction:
Not Available

# Macromolecular_Interacting_Partner_30_Pfam_Domain_Function:
PF00631:G-gamma

# Macromolecular_Interacting_Partner_30_Signals:
None

# Macromolecular_Interacting_Partner_30_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_30_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_30_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_30_GenBank_ID_Protein:
20147633

# Macromolecular_Interacting_Partner_30_SwissProt_ID:
GBG2_HUMAN (P59768)

# Macromolecular_Interacting_Partner_30_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_30_Genecard_id:
GNG2

# Macromolecular_Interacting_Partner_30_Geneatlas_id:
GNG2

# Macromolecular_Interacting_Partner_30_hgnc_id:
HGNC:4404

# Macromolecular_Interacting_Partner_30_PDB_ID:
1GP2

# Macromolecular_Interacting_Partner_30_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_30_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_30_Subcellular_Location:
Cell membrane; lipid-anchor; cytoplasmic side (Potential)

# Macromolecular_Interacting_Partner_30_Gene_Sequence:
>216 bp
ATGGCCAGCAACAACACCGCCAGCATAGCACAAGCCAGGAAGCTGGTAGAGCAGCTTAAG
ATGGAAGCCAATATCGACAGGATAAAGGTGTCCAAGGCAGCTGCAGATTTGATGGCCTAC
TGTGAAGCACATGCCAAGGAAGACCCCCTCCTGACCCCTGTTCCGGCTTCAGAAAACCCG
TTTAGGGAGAAGAAGTTTTTCTGTGCCATCCTTTAA

# Macromolecular_Interacting_Partner_30_GenBank_ID_Gene:
AF493870

# Macromolecular_Interacting_Partner_30_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_30_Locus:
14q21

# Macromolecular_Interacting_Partner_30_SNPs:
rs2173147; rs1540703; rs1057804; rs1890698; rs1953861; rs1253671; rs1253705; rs10150753; rs4898723; rs8008081; rs4271524; rs8014746; rs8017436; rs2357306; rs1618825; rs8006278; rs1959517; rs4271525; rs1253685; rs8019194; rs1253687; rs1693198; rs1253707; rs3204006; rs6572805; rs1253669; rs8014732; rs7153584; rs12883315; rs6572803; rs4901174; rs1253696; rs12883290; rs7158342; rs8019331; rs11157869; rs12435475; rs10131301; rs12889199; rs4898725; rs1253690; rs7154422; rs6572804; rs8011452; rs1253703; rs12435509; rs2000006; rs4901173; rs6572802; rs1253691; rs11621156; rs11851703; rs7160163; rs7154419; rs11157865; rs11623465; rs1253708; rs1253672; rs10143072; rs8020243; rs10498440; rs8015777; rs11623590; rs1253692; rs11157864; rs11623924; rs7152919; rs11624752; rs17124753; rs11625611; rs1959518; rs2357302; rs12434038; rs12894908; rs12882906; rs1874566; rs8019382; rs3742539; rs11621160; rs8007155; rs10498438; rs1343870; rs10498439; rs8010684; rs1953859; rs1253686; rs12147761; rs1890699; rs10129965; rs11157866; rs2357249; rs4901171; rs1623101; rs11624779; rs8009095; rs12588848; rs1693203; rs1253698; rs4514593; rs10133203; rs1253704; rs3742541; rs2275459; rs8009132; rs11622145; rs1253706; rs10146408; rs7143686; rs2357247; rs1253699; rs7150643; rs8010820; rs10147806; rs17124732; rs1253689; rs1253700; rs2357304; rs1269967; rs9635225; rs17124751; rs1953858; rs7148779; rs35277565; rs12588519; rs11625461; rs8003709; rs8009835; rs10147177; rs4901175; rs1253693; rs11628249; rs8009405; rs10144829; rs1693199; rs12880965; rs2357305; rs8014838; rs8005440; rs7143789; rs12890422; rs12100449; rs3818870; rs1316298; rs7494751; rs1578974; rs17124744; rs11621108; rs3742540; rs7144109; rs1253702; rs17252733; rs17124725; rs17124746; rs3742537; rs1109745; rs12101277; rs1253701; rs11850819; rs8010780; rs10220546; rs17124713; rs12895034; rs17124709; rs7153274; rs3204008; rs11847330; rs1253632; rs1262155; rs17092983; rs3825596; rs7143009; rs1253656; rs1693204; rs1253636; rs1253634; rs4898728; rs1032583; rs1032582; rs1253657; rs7141670; rs3825604; rs10873055; rs8019374; rs7147405; rs1253660; rs4633613; rs1253655; rs1253645; rs3825603; rs3825597; rs12431532; rs1253646; rs1253633; rs3825602; rs2236561; rs1253642; rs1032584; rs1253643; rs1253648; rs1253658; rs1253644; rs17124780; rs12432144; rs1253647; rs12436573; rs1271518; rs1253664; rs12433722; rs1253652; rs17124772; rs3825600; rs17124796; rs4898727; rs1253639; rs1497089; rs12431528; rs11850096; rs1253662; rs1253665; rs12433696; rs1253640; rs12894196; rs1272117; rs1253649; rs11847688; rs1253638; rs17124774; rs1253641; rs3825601; rs1693177; rs1253635; rs2236562; rs17124768; rs11157867; rs1253653; rs8019625; rs1253654; rs7144097; rs1253663; rs11847372; rs7159454; rs11157868; rs1253650; rs17831501; rs1253666; rs1253651; rs17124698; rs9743514; rs950010; rs12889322; rs36047102; rs36067357; rs35614601; rs4523850; rs35174771; rs35178030; rs35139612; rs12889284; rs7148451; rs35822692; rs12886703; rs35819066; rs35462757; rs10539775; rs35213821; rs35673554; rs17831464; rs8011560; rs17124735; rs35190987; rs34192983; rs2884152; rs35975919; rs28694719; rs1497081; rs36016212; rs10717240; rs34445110; rs11354444; rs35455303; rs36032151; rs7158119; rs4898724; rs34308582; rs34283228; rs5808640; rs8011272; rs34329964; rs35145745; rs34857364; rs1693193; rs12890418; rs34693198; rs12586590; rs10689259; rs35336316; rs11322637; rs11322270; rs34146466; rs35195529; rs35803539; rs4347544; rs2067829; rs11428089; rs1953860; rs17252712; rs5808641; rs34973942; rs11315945; rs34499635; rs33911162; rs35429944; rs35289455; rs7161446; rs28718093; rs8013372; rs1253688; rs2357303; rs34764790; rs7156066; rs10543520; rs34028168; rs11623464; rs1253694; rs10150861; rs34653407; rs35238426; rs35433627; rs35848969; rs1959516; rs12586607; rs35870554; rs28459525; rs35495615; rs10083534; rs10539774; rs35583464; rs35727674; rs35105434; rs12882099; rs33955770; rs12895248; rs11463019; rs1272118; rs1253695; rs34361665; rs1253697; rs12894239; rs8005542; rs34031930; rs35437257; rs35846208; rs35134680; rs36078788; rs34449528; rs28410474; rs12896633; rs35857266; rs35561589; rs35748925; rs34420705; rs3030340; rs35420086; rs12589934; rs35009719; rs36010201; rs34591914; rs1959519; rs34670484; rs11288986; rs34986921; rs35088349; rs12894231; rs35622909; rs34263394; rs34779533; rs4456417; rs8010602; rs10624821; rs34877164; rs33974701; rs4901172; rs34780909; rs34248762; rs4309306; rs34782634; rs5808639; rs8004034; rs35616481; rs5808645; rs34701338; rs34410329; rs17124728; rs34480788; rs35453948; rs12889304; rs9707478; rs35484737; rs10604942; rs35494600; rs3832939; rs36123684; rs35923674; rs35156219; rs4898726; rs35052096; rs35374258; rs34240079; rs34350221; rs28688492; rs35192783; rs35005802; rs34991244; rs34006183; rs10134518; rs10140188; rs2357248; rs1253673; rs5808642; rs2047364; rs34966733; rs1620540; rs34110528; rs17124723; rs33933786; rs6145342; rs33922275; rs34470726; rs5808643; rs2790507; rs35561836; rs35675957; rs1769485; rs34653524; rs35548218; rs1693171; rs4589468; rs35319859; rs35289575; rs1269018; rs11326387; rs11301975; rs1769484; rs34265134; rs10646775; rs10636640; rs11301974; rs1253637; rs1693172; rs10684028; rs1693202; rs28437731; rs11847369; rs3825598; rs28613476; rs10643481; rs34424623; rs34270098; rs5808644; rs17252747; rs1253659; rs35702479; rs33913949; rs35088804; rs1253661; rs35348536; rs1769486; rs34736340; rs11847426; rs17831409; rs35153814; rs10529707; rs10137625; rs10138800; rs10145910; rs10146660; rs10150721; rs10151155; rs11844663; rs11844741; rs12433790; rs12436400; rs12436887; rs12587228; rs12589956; rs12878101; rs12878420; rs12886319; rs1693194; rs1693195; rs17124691; rs17124692; rs17124695; rs17124696; rs17124815; rs17252644; rs1769483; rs2357245; rs2357246; rs34468044; rs34867128; rs4901170; rs7154813

# Macromolecular_Interacting_Partner_30_General_References:
10833460

# Macromolecular_Interacting_Partner_30_References:
16831450; 16845489; 16924114

# Macromolecular_Interacting_Partner_31_ID:
7130

# Macromolecular_Interacting_Partner_31_Name:
Calmodulin

# Macromolecular_Interacting_Partner_31_Synonyms:
CaM

# Macromolecular_Interacting_Partner_31_Gene_Name:
CALM1

# Macromolecular_Interacting_Partner_31_Protein_Sequence:
>Calmodulin
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

# Macromolecular_Interacting_Partner_31_Number_of_Residues:
149

# Macromolecular_Interacting_Partner_31_Molecular_Weight:
16838

# Macromolecular_Interacting_Partner_31_Theoretical_pI:
3.84

# Macromolecular_Interacting_Partner_31_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_31_General_Function:
Not Available

# Macromolecular_Interacting_Partner_31_Specific_Function:
Calmodulin mediates the control of a large number of enzymes and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases

# Macromolecular_Interacting_Partner_31_Pathway:
Not Available

# Macromolecular_Interacting_Partner_31_Reaction:
Not Available

# Macromolecular_Interacting_Partner_31_Pfam_Domain_Function:
PF00036:efhand

# Macromolecular_Interacting_Partner_31_Signals:
None

# Macromolecular_Interacting_Partner_31_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_31_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_31_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_31_GenBank_ID_Protein:
179888

# Macromolecular_Interacting_Partner_31_SwissProt_ID:
CALM_HUMAN (P62158)

# Macromolecular_Interacting_Partner_31_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_31_Genecard_id:
CALM1

# Macromolecular_Interacting_Partner_31_Geneatlas_id:
CALM1

# Macromolecular_Interacting_Partner_31_hgnc_id:
HGNC:1442

# Macromolecular_Interacting_Partner_31_PDB_ID:
1IQ5

# Macromolecular_Interacting_Partner_31_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_31_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_31_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_31_Gene_Sequence:
>450 bp
ATGGCTGACCAGCTGACTGAGGAGCAGATTGCAGAGTTCAAGGAGGCCTTCTCCCTCTTT
GACAAGGATGGAGATGGCACTATCACCACCAAGGAGTTGGGGACAGTGATGAGATCCCTG
GGACAGAACCCCACTGAAGCAGAGCTGCAGGATATGATCAATGAGGTGGATGCAGATGGG
AACGGGACCATTGACTTCCCGGAGTTCCTGACCATGATGGCCAGAAAGATGAAGGACACA
GACAGTGAGGAGGAGATCCGAGAGGCGTTCCGTGTCTTTGACAAGGATGGGAATGGCTAC
ATCAGCGCCGCAGAGCTGCGTCACGTAATGACGAACCTGGGGGAGAAGCTGACCGATGAG
GAGGTGGATGAGATGATCAGGGAGGCTGACATCGATGGAGATGGCCAGGTCAATTATGAA
GAGTTTGTACAGATGATGACTGCAAAGTGA

# Macromolecular_Interacting_Partner_31_GenBank_ID_Gene:
J04046

# Macromolecular_Interacting_Partner_31_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_31_Locus:
14q24-q31

# Macromolecular_Interacting_Partner_31_SNPs:
rs1059296; rs3179089; rs3814843; rs5871; rs3814845; rs12886342; rs3814846; rs1058903; rs3213718; rs2300499; rs9646173; rs2300501; rs2300502; rs2268433; rs2300497; rs3729787; rs2300500; rs3213719; rs7156456; rs3729785; rs2300496; rs3729783; rs2300498; rs3759708; rs11621831; rs3814847; rs12885713; rs11541171; rs11541170; rs11287138; rs35418035; rs15414; rs12886083; rs1059285; rs3814844; rs12886186; rs11539544; rs35149335; rs11541173; rs12895206; rs33952244; rs7155325; rs3060982; rs10140889; rs41304357; rs35204775; rs28691160; rs41317298; rs34384220; rs7155363; rs35428964; rs33976329; rs34825576; rs3729786; rs41307098; rs12886752; rs28460357; rs12894793; rs34068835; rs34704743; rs5810498; rs35688922; rs4620900; rs7148581; rs34983137; rs10146938; rs10148565; rs10873403; rs11629265; rs12891145; rs17126708; rs17126717; rs17126719; rs2068086; rs2110114; rs2401887; rs2896135; rs4904687; rs6575131; rs6575134; rs7144225; rs8006462; rs876259

# Macromolecular_Interacting_Partner_31_General_References:
3182832; 2445749; 6385987; 2223880; 7925473; 9681195; 12508121; 7093203; 11807546

# Macromolecular_Interacting_Partner_31_References:
16880265; 16881052; 16945434

# Macromolecular_Interacting_Partner_32_ID:
7739

# Macromolecular_Interacting_Partner_32_Name:
Protein phosphatase 1 regulatory subunit 1B

# Macromolecular_Interacting_Partner_32_Synonyms:
Dopamine- and cAMP- regulated neuronal phosphoprotein; DARPP-32

# Macromolecular_Interacting_Partner_32_Gene_Name:
PPP1R1B

# Macromolecular_Interacting_Partner_32_Protein_Sequence:
>Protein phosphatase 1 regulatory subunit 1
BMDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASG
EGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPRE
EDEEEEEDDEEEEEEEDSQAEVLKVIRQSAGQKTTCGQGLEGPWERPPPLDESERDGGSE
DQVEDPALSEPGEEPQRPSPSEPGT

# Macromolecular_Interacting_Partner_32_Number_of_Residues:
204

# Macromolecular_Interacting_Partner_32_Molecular_Weight:
22963

# Macromolecular_Interacting_Partner_32_Theoretical_pI:
4.18

# Macromolecular_Interacting_Partner_32_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  phosphatase inhibitor activity
Function:  protein phosphatase inhibitor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_32_General_Function:
Not Available

# Macromolecular_Interacting_Partner_32_Specific_Function:
Inhibitor of protein-phosphatase 1

# Macromolecular_Interacting_Partner_32_Pathway:
Not Available

# Macromolecular_Interacting_Partner_32_Reaction:
Not Available

# Macromolecular_Interacting_Partner_32_Pfam_Domain_Function:
PF05395:DARPP-32

# Macromolecular_Interacting_Partner_32_Signals:
None

# Macromolecular_Interacting_Partner_32_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_32_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_32_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_32_GenBank_ID_Protein:
21717548

# Macromolecular_Interacting_Partner_32_SwissProt_ID:
PPR1B_HUMAN (Q9UD71)

# Macromolecular_Interacting_Partner_32_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_32_Genecard_id:
PPP1R1B

# Macromolecular_Interacting_Partner_32_Geneatlas_id:
PPP1R1B

# Macromolecular_Interacting_Partner_32_hgnc_id:
HGNC:9287

# Macromolecular_Interacting_Partner_32_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_32_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_32_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_32_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_32_Gene_Sequence:
>615 bp
ATGGACCCCAAGGACCGCAAGAAGATCCAGTTCTCGGTGCCCGCGCCCCCTAGCCAGCTC
GACCCCCGCCAGGTGGAGATGATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGG
CTCTCAGAGCACTCCTCACCAGAGGAGGAAGCCTCCCCCCACCAGAGAGCCTCAGGAGAG
GGGCACCATCTCAAGTCGAAGAGACCCAACCCCTGTGCCTACACACCACCTTCGCTGAAA
GCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAG
GCCTCAGAGGAGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAA
GATGAGGAGGAAGAGGAGGATGATGAAGAAGAGGAAGAAGAAGAGGACAGCCAGGCTGAA
GTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAA
GGGCCCTGGGAGCGCCCACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCTCTGAGGAC
CAAGTGGAAGACCCAGCACTAAGTGAGCCTGGGGAGGAACCTCAGCGCCCTTCCCCCTCT
GAGCCTGGCACATAG

# Macromolecular_Interacting_Partner_32_GenBank_ID_Gene:
AF464196

# Macromolecular_Interacting_Partner_32_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_32_Locus:
17q12

# Macromolecular_Interacting_Partner_32_SNPs:
rs2271309; rs33938012; rs33932099; rs907094; rs3764352; rs12601930; rs16965199; rs3751903; rs33978574; rs1495099; rs879606; rs10852934; rs4795390; rs9899653; rs35898202; rs34445181; rs34056202; rs35591311; rs34026896; rs3764353; rs392741; rs11869360; rs34848496; rs380503; rs35751045; rs11651497; rs451849; rs34773471; rs34963535; rs34719599; rs35163040; rs35998983; rs5820300; rs34433367; rs3029546; rs11651233; rs193359; rs3029545; rs35574838; rs3029547; rs9892853; rs12937003; rs1874224; rs1874225; rs1874228; rs2132140; rs2665646; rs33953566; rs34257414; rs35825115; rs3817160; rs4513130; rs7212852; rs734645; rs8066399; rs8075130; rs9532; rs9896679; rs9913626

# Macromolecular_Interacting_Partner_32_General_References:
8120638; 12124342; 10604473

# Macromolecular_Interacting_Partner_32_References:
16670371; 16710312; 16730373; 16750892

# Macromolecular_Interacting_Partner_33_ID:
7993

# Macromolecular_Interacting_Partner_33_Name:
Suppressor of cytokine signaling 3

# Macromolecular_Interacting_Partner_33_Synonyms:
SOCS-3; Cytokine-inducible SH2 protein 3; CIS-3; STAT-induced STAT inhibitor 3; SSI-3

# Macromolecular_Interacting_Partner_33_Gene_Name:
SOCS3

# Macromolecular_Interacting_Partner_33_Protein_Sequence:
>Suppressor of cytokine signaling 3
MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLL
SAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCV
LKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSR
PLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL

# Macromolecular_Interacting_Partner_33_Number_of_Residues:
225

# Macromolecular_Interacting_Partner_33_Molecular_Weight:
24770

# Macromolecular_Interacting_Partner_33_Theoretical_pI:
9.08

# Macromolecular_Interacting_Partner_33_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_33_General_Function:
Not Available

# Macromolecular_Interacting_Partner_33_Specific_Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo

# Macromolecular_Interacting_Partner_33_Pathway:
Not Available

# Macromolecular_Interacting_Partner_33_Reaction:
Not Available

# Macromolecular_Interacting_Partner_33_Pfam_Domain_Function:
PF00017:SH2;
PF07525:SOCS_box

# Macromolecular_Interacting_Partner_33_Signals:
None

# Macromolecular_Interacting_Partner_33_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_33_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_33_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_33_GenBank_ID_Protein:
2443363

# Macromolecular_Interacting_Partner_33_SwissProt_ID:
SOCS3_HUMAN (O14543)

# Macromolecular_Interacting_Partner_33_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_33_Genecard_id:
SOCS3

# Macromolecular_Interacting_Partner_33_Geneatlas_id:
SOCS3

# Macromolecular_Interacting_Partner_33_hgnc_id:
HGNC:19391

# Macromolecular_Interacting_Partner_33_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_33_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_33_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_33_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_33_Gene_Sequence:
>678 bp
ATGGTCACCCACAGCAAGTTTCCCGCCGCCGGGATGAGCCGCCCCCTGGACACCAGCCTG
CGCCTCAAGACCTTCAGCTCCAAGAGCGAGTACCAGCTGGTGGTGAACGCAGTGCGCAAG
CTGCAGGAGAGCGGCTTCTACTGGAGCGCAGTGACCGGCGGCGAGGCGAACCTGCTGCTC
AGTGCCGAGCCCGCCGGCACCTTTCTGATCCGCGACAGCTCGGACCAGCGCCACTTCTTC
GCGCTCAGCGTCAAGACCCAGTCTGGGACCAAGAACCTGCGCATCCAGTGTGAGGGGGGC
AGCTTCTCTCTGCAGAGCGATCCCCGGAGCACGCAGCCCGTGCCCCGCTTCGACTGCGTG
CTCAAGCTGGTGTACCACTACATGCCGCCCCCTGGAGCCCCCTCCTTCCCCTCGCCACCT
ACTGAACCCTCCTCCGAGGTGCCCGAGCAGCCGTCTGCCCAGCCACTCCCTGGGAGTCCC
CCCAGAAGAGCCTATTACATCTACTCCGGGGGCGAGAAGATCCCCCTGGTGTTGAGCCGG
CCCCTCTCCTCCAACGTGGCCACTCTTCAGCATCTCTGTCGGAAGACCGTCAACGGCCAC
CTGGACTCCTATGAGAAAGTCACCCAGCTGCCGGGGCCCATTCGGGAGTTCCTGGACCAG
TACGATGCCCCGCTTTAA

# Macromolecular_Interacting_Partner_33_GenBank_ID_Gene:
AB004904

# Macromolecular_Interacting_Partner_33_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_33_Locus:
17q25.3

# Macromolecular_Interacting_Partner_33_SNPs:
rs1061489; rs41522945; rs4969168; rs2280148; rs8064821; rs12185261; rs17849241; rs12059; rs12953258; rs4969169; rs7207782; rs34309315; rs11420236; rs11406505; rs12946530; rs12944731; rs11868378; rs35037722; rs11077357; rs2176035; rs4969170; rs4969172; rs4994934; rs7222563; rs8069976; rs8071356; rs8074003; rs9892622; rs9914220

# Macromolecular_Interacting_Partner_33_General_References:
9266833; 9344848; 11071852; 10421843; 12027890

# Macromolecular_Interacting_Partner_33_References:
16709613; 16914720

# Macromolecular_Interacting_Partner_34_ID:
8164

# Macromolecular_Interacting_Partner_34_Name:
Interferon regulatory factor 6

# Macromolecular_Interacting_Partner_34_Synonyms:
IRF-6

# Macromolecular_Interacting_Partner_34_Gene_Name:
IRF6

# Macromolecular_Interacting_Partner_34_Protein_Sequence:
>Interferon regulatory factor 6
MALHPRRVRLKPWLVAQVDSGLYPGLIWLHRDSKRFQIPWKHATRHSPQQEEENTIFKAW
AVETGKYQEGVDDPDPAKWKAQLRCALNKSREFNLMYDGTKEVPMNPVKIYQVCDIPQPQ
GSIINPGSTGSAPWDEKDNDVDEEDEEDELDQSQHHVPIQDTFPFLNINGSPMAPASVGN
CSVGNCSPEAVWPKTEPLEMEVPQAPIQPFYSSPELWISSLPMTDLDIKFQYRGKEYGQT
MTVSNPQGCRLFYGDLGPMPDQEELFGPVSLEQVKFPGPEHITNEKQKLFTSKLLDVMDR
GLILEVSGHAIYAIRLCQCKVYWSGPCAPSLVAPNLIERQKKVKLFCLETFLSDLIAHQK
GQIEKQPPFEIYLCFGEEWPDGKPLERKLILVQVIPVVARMIYEMFSGDFTRSFDSGSVR
LQISTPDIKDNIVAQLKQLYRILQTQESWQPMQPTPSMQLPPALPPQ

# Macromolecular_Interacting_Partner_34_Number_of_Residues:
467

# Macromolecular_Interacting_Partner_34_Molecular_Weight:
53130

# Macromolecular_Interacting_Partner_34_Theoretical_pI:
4.97

# Macromolecular_Interacting_Partner_34_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  cell
Component:  intracellular
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_34_General_Function:
Not Available

# Macromolecular_Interacting_Partner_34_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_34_Pathway:
Not Available

# Macromolecular_Interacting_Partner_34_Reaction:
Not Available

# Macromolecular_Interacting_Partner_34_Pfam_Domain_Function:
PF00605:IRF

# Macromolecular_Interacting_Partner_34_Signals:
None

# Macromolecular_Interacting_Partner_34_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_34_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_34_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_34_GenBank_ID_Protein:
2599385

# Macromolecular_Interacting_Partner_34_SwissProt_ID:
IRF6_HUMAN (O14896)

# Macromolecular_Interacting_Partner_34_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_34_Genecard_id:
IRF6

# Macromolecular_Interacting_Partner_34_Geneatlas_id:
IRF6

# Macromolecular_Interacting_Partner_34_hgnc_id:
HGNC:6121

# Macromolecular_Interacting_Partner_34_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_34_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_34_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_34_Subcellular_Location:
Nucleus (Potential)

# Macromolecular_Interacting_Partner_34_Gene_Sequence:
>1404 bp
ATGGCCCTCCACCCCCGCAGAGTCCGGCTAAAGCCCTGGCTGGTGGCCCAGGTGGATAGT
GGCCTCTACCCTGGGCTCATCTGGCTACACAGGGACTCTAAACGCTTCCAGATTCCCTGG
AAACATGCCACCCGGCATAGCCCTCAACAAGAAGAGGAAAATACCATTTTTAAGGCCTGG
GCTGTAGAGACAGGGAAGTACCAGGAAGGGGTGGATGACCCTGACCCAGCTAAATGGAAG
GCCCAGCTGCGCTGTGCTCTCAATAAGAGCAGAGAATTCAACCTGATGTATGATGGCACC
AAGGAGGTGCCCATGAACCCAGTGAAGATATATCAAGTGTGTGACATCCCTCAGCCCCAG
GGCTCGATCATTAACCCAGGATCCACAGGGTCTGCTCCCTGGGATGAGAAGGATAATGAT
GTGGATGAAGAAGATGAGGAAGATGAGCTGGATCAGTCGCAGCACCATGTTCCCATCCAG
GACACCTTCCCCTTCCTGAACATCAATGGTTCTCCCATGGCGCCAGCCAGTGTGGGCAAT
TGCAGTGTGGGCAACTGCAGCCCGGAGGCAGTGTGGCCCAAAACTGAACCCCTGGAGATG
GAAGTACCCCAGGCACCTATACAGCCCTTCTATAGCTCTCCAGAACTGTGGATCAGCTCT
CTCCCAATGACTGACCTGGACATCAAGTTTCAGTACCGTGGGAAGGAGTACGGGCAGACC
ATGACCGTGAGCAACCCTCAGGGCTGCCGACTCTTCTATGGGGACCTGGGTCCCATGCCT
GACCAGGAGGAGCTCTTTGGTCCCGTCAGCCTGGAGCAGGTCAAATTCCCAGGTCCTGAG
CATATTACCAATGAGAAGCAGAAGCTGTTCACTAGCAAGCTGCTGGACGTCATGGACAGA
GGACTGATCCTGGAGGTCAGCGGTCATGCCATTTATGCCATCAGGCTGTGCCAGTGCAAG
GTGTACTGGTCTGGGCCATGTGCCCCATCACTTGTTGCTCCCAACCTGATTGAGAGACAA
AAGAAGGTCAAGCTATTTTGTCTGGAAACATTCCTTAGCGATCTCATTGCCCACCAGAAA
GGACAGATAGAGAAGCAGCCACCGTTTGAGATCTACTTATGCTTTGGGGAAGAATGGCCA
GATGGGAAACCATTGGAAAGGAAACTCATCTTGGTTCAGGTCATTCCAGTAGTGGCTCGG
ATGATCTACGAGATGTTTTCTGGTGATTTCACACGATCCTTTGATAGTGGCAGTGTCCGC
CTGCAGATCTCAACCCCAGACATCAAGGATAACATCGTTGCTCAGCTGAAGCAGCTGTAC
CGCATCCTTCAAACCCAGGAGAGCTGGCAGCCCATGCAGCCCACCCCCAGCATGCAACTG
CCCCCTGCCCTGCCTCCCCAGTAA

# Macromolecular_Interacting_Partner_34_GenBank_ID_Gene:
AF027292

# Macromolecular_Interacting_Partner_34_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_34_Locus:
1q32.3-q41

# Macromolecular_Interacting_Partner_34_SNPs:
rs2235371; rs2013162; rs2073487; rs2073486; rs12403599; rs3753518; rs682461; rs861019; rs17317411; rs12405750; rs861020; rs3753517; rs6540557; rs17015239; rs2235377; rs2235376; rs17015250; rs674433; rs2013196; rs2235373; rs2294408; rs622832; rs2236906; rs595918; rs2236908; rs1160411; rs2236909; rs7552506; rs2235375; rs2073485; rs6685182; rs2005982; rs17015218; rs11811534; rs926347; rs926348; rs4844494; rs17015226; rs2236907; rs7533957; rs17015224; rs17015217; rs614662; rs7555285; rs926346; rs17389436; rs2179254; rs742214; rs1005287; rs742215; rs12403006; rs2357229; rs7545542; rs599021; rs7545538; rs6659549; rs2235372; rs846808; rs12126910; rs41303263; rs34907424; rs4844901; rs11577244; rs12032189; rs6694552; rs34401647; rs34620746; rs34349445; rs12061620; rs34088658; rs34893273; rs5780538; rs41304121; rs12127839; rs11418099; rs35517496; rs35770035; rs3028134; rs6664908; rs7522250; rs10590124; rs1160137; rs846810; rs35932305; rs4333847; rs34161361; rs35625939; rs1474608; rs35878470; rs12032428; rs10692470; rs36017607; rs6692965; rs4027451; rs11277368; rs34765366; rs36000807; rs35314858; rs3028138; rs34540624; rs34743335; rs34156367; rs4844899; rs11272620; rs10489343; rs10863790; rs11119346; rs11119347; rs11590807; rs11803382; rs11807508; rs12081405; rs12083685; rs12143281; rs12744453; rs17015268; rs17389541; rs2069068; rs2076153; rs4844895; rs623360; rs630984; rs642961; rs651141; rs6696825; rs6699507; rs7550857; rs7555528; rs764093

# Macromolecular_Interacting_Partner_34_General_References:
12219090

# Macromolecular_Interacting_Partner_34_References:
16751174; 16785499; 17008068; 17064391

# Macromolecular_Interacting_Partner_35_ID:
8206

# Macromolecular_Interacting_Partner_35_Name:
Nitric-oxide synthase, endothelial

# Macromolecular_Interacting_Partner_35_Synonyms:
EC-NOS; NOS type III; NOSIII; Endothelial NOS; eNOS; Constitutive NOS; cNOS

# Macromolecular_Interacting_Partner_35_Gene_Name:
NOS3

# Macromolecular_Interacting_Partner_35_Protein_Sequence:
>Nitricoxide synthase, endothelial
MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAPEHSPPSSPLT
QPPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAP
EQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRN
APRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGD
FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPP
ELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMST
EIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDH
HAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW
KGSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGR
LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSS
PRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHF
CAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAA
RDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATIRSVENLQSSKSTRATIL
VRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGP
PPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRRY
EEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVL
AYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAP
FRGFWQERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSRE
PDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDMELD
EAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPGSDT
NSP

# Macromolecular_Interacting_Partner_35_Number_of_Residues:
1203

# Macromolecular_Interacting_Partner_35_Molecular_Weight:
133290

# Macromolecular_Interacting_Partner_35_Theoretical_pI:
7.27

# Macromolecular_Interacting_Partner_35_GO_Classification:
>>>
Function:  monooxygenase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen
Function:  nitric-oxide synthase activity
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  biosynthesis
Process:  nitric oxide biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_35_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_35_Specific_Function:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets

# Macromolecular_Interacting_Partner_35_Pathway:
map00330  Arginine and proline metabolism

# Macromolecular_Interacting_Partner_35_Reaction:
L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+

# Macromolecular_Interacting_Partner_35_Pfam_Domain_Function:
PF00667:FAD_binding_1;
PF00258:Flavodoxin_1;
PF00175:NAD_binding_1;
PF02898:NO_synthase

# Macromolecular_Interacting_Partner_35_Signals:
None

# Macromolecular_Interacting_Partner_35_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_35_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_35_EC_Link:
EC 1.14.13.39

# Macromolecular_Interacting_Partner_35_GenBank_ID_Protein:
189212

# Macromolecular_Interacting_Partner_35_SwissProt_ID:
NOS3_HUMAN (P29474)

# Macromolecular_Interacting_Partner_35_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_35_Genecard_id:
NOS3

# Macromolecular_Interacting_Partner_35_Geneatlas_id:
NOS3

# Macromolecular_Interacting_Partner_35_hgnc_id:
HGNC:7876

# Macromolecular_Interacting_Partner_35_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_35_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_35_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_35_Subcellular_Location:
Cell membrane; caveola. Cytoplasm; cytoskeleton. Golgi apparatus. Note= Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity

# Macromolecular_Interacting_Partner_35_Gene_Sequence:
>3612 bp
ATGGGCAACTTGAAGAGCGTGGCCCAGGAGCCTGGGCCACCCTGCGGCCTGGGGCTGGGG
CTGGGCCTTGGGCTGTGCGGCAAGCAGGGCCCAGCCACCCCGGCCCCTGAGCCCAGCCGG
GCCCCAGCATCCCTACTCCCACCAGCGCCAGAACACAGCCCCCCGAGCTCCCCGCTAACC
CAGCCCCCAGAGGGGCCCAAGTTCCCTCGTGTGAAGAACTGGGAGGTGGGGAGCATCACC
TATGACACCCTCAGCGCCCAGGCGCAGCAGGATGGGCCCTGCACCCCAAGACGCTGCCTG
GGCTCCCTGGTATTTCCACGGAAACTACAGGGCCGGCCCTCCCCCGGCCCCCCGGCCCCT
GAGCAGCTGCTGAGTCAGGCCCGGGACTTCATCAACCAGTACTACAGCTCCATTAAGAGG
AGCGGCTCCCAGGCCCACGAACAGCGGCTTCAAGAGGTGGAAGCCGAGGTGGCAGCCACA
GGCACCTACCAGCTTAGGGAGAGCGAGCTGGTGTTCGGGGCTAAGCAGGCCTGGCGCAAC
GCTCCCCGCTGCGTGGGCCGGATCCAGTGGGGGAAGCTGCAGGTGTTCGATGCCCGGGAC
TGCAGGTCTGCACAGGAAATGTTCACCTACATCTGCAACCACATCAAGTATGCCACCAAC
CGGGGCAACCTTCGCTCGGCCATCACAGTGTTCCCGCAGCGCTGCCCTGGCCGAGGAGAC
TTCCGAATCTGGAACAGCCAGCTGGTGCGCTACGCGGGCTACCGGCAGCAGGACGGCTCT
GTGCGGGGGGACCCAGCCAACGTGGAGATCACCGAGCTCTGCATTCAGCACGGCTGGACC
CCAGGAAACGGTCGCTTCGACGTGCTGCCCCTGCTGCTGCAGGCCCCAGATGAGCCCCCA
GAACTCTTCCTTCTGCCCCCCGAGCTGGTCCTTGAGGTGCCCCTGGAGCACCCCACGCTG
GAGTGGTTTGCAGCCCTGGGCCTGCGCTGGTACGCCCTCCCGGCAGTGTCCAACATGCTG
CTGGAAATTGGGGGCCTGGAGTTCCCCGCAGCCCCCTTCAGTGGCTGGTACATGAGCACT
GAGATCGGCACGAGGAACCTGTGTGACCCTCACCGCTACAACATCCTGGAGGATGTGGCT
GTCTGCATGGACCTGGATACCCGGACCACCTCGTCCCTGTGGAAAGACAAGGCAGCAGTG
GAAATCAACGTGGCCGTGCTGCACAGTTACCAGCTAGCCAAAGTCACCATCGTGGACCAC
CACGCCGCCACGGCCTCTTTCATGAAGCACCTGGAGAATGAGCAGAAGGCCAGGGGGGGC
TGCCCTGCAGACTGGGCCTGGATCGTGCCCCCCATCTCGGGCAGCCTCACTCCTGTTTTC
CATCAGGAGATGGTCAACTATTTCCTGTCCCCGGCCTTCCGCTACCAGCCAGACCCCTGG
AAGGGGAGTGCCGCCAAGGGCACCGGCATCACCAGGAAGAAGACCTTTAAAGAAGTGGCC
AACGCCGTGAAGATCTCCGCCTCGCTCATGGGCACGGTGATGGCGAAGCGAGTGAAGGCG
ACAATCCTGTATGGCTCCGAGACCGGCCGGGCCCAGAGCTACGCACAGCAGCTGGGGAGA
CTCTTCCGGAAGGCTTTTGATCCCCGGGTCCTGTGTATGGATGAGTATGACGTGGTGTCC
CTCGAACACGAGACGCTGGTGCTGGTGGTAACCAGCACATTTGGGAATGGGGATCCCCCG
GAGAATGGAGAGAGCTTTGCAGCTGCCCTGATGGAGATGTCCGGCCCCTACAACAGCTCC
CCTCGGCCGGAACAGCACAAGAGTTATAAGATCCGCTTCAACAGCATCTCCTGCTCAGAC
CCACTGGTGTCCTCTTGGCGGCGGAAGAGGAAGGAGTCCAGTAACACAGACAGTGCAGGG
GCCCTGGGCACCCTCAGGTTCTGTGTGTTCGGGCTCGGCTCCCGGGCATACCCCCACTTC
TGCGCCTTTGCTCGTGCCGTGGACACACGGCTGGAGGAACTGGGCGGGGAGCGGCTGCTG
CAGCTGGGCCAGGGCGACGAGCTGTGCGGCCAGGAGGAGGCCTTCCGAGGCTGGGCCCAG
GCTGCCTTCCAGGCCGCCTGTGAGACCTTCTGTGTGGGAGAGGATGCCAAGGCCGCCGCC
CGAGACATCTTCAGCCCCAAACGGAGCTGGAAGCGCCAGAGGTACCGGCTGAGCGCCCAG
GCCGAGGGCCTGCAGTTGCTGCCAGGTCTGATCCACGTGCACAGGCGGAAGATGTTCCAG
GCTACAATCCGCTCAGTGGAAAACCTGCAAAGCAGCAAGTCCACGAGGGCCACCATCCTG
GTGCGCCTGGACACCGGAGGCCAGGAGGGGCTGCAGTACCAGCCGGGGGACCACATAGGT
GTCTGCCCGCCCAACCGGCCCGGCCTTGTGGAGGCGCTGCTGAGCCGCGTGGAGGACCCG
CCGGCGCCCACTGAGCCCGTGGCAGTAGAGCAGCTGGAGAAGGGCAGCCCTGGTGGCCCT
CCCCCCGGCTGGGTGCGGGACCCCCGGCTGCCCCCGTGCACGCTGCGCCAGGCTCTCACC
TTCTTCCTGGACATCACCTCCCCACCCAGCCCTCAGCTCTTGCGGCTGCTCAGCACCTTG
GCAGAAGAGCCCAGGGAACAGCAGGAGCTGGAGGCCCTCAGCCAGGATCCCCGACGCTAC
GAGGAGTGGAAGTGGTTCCGCTGCCCCACGCTGCTGGAGGTGCTGGAGCAGTTCCCGTCG
GTGGCGCTGCCTGCCCCACTGCTCCTCACCCAGCTGCCTCTGCTCCAGCCCCGGTACTAC
TCAGTCAGCTCGGCACCCAGCACCCACCCAGGAGAGATCCACCTCACTGTAGCTGTGCTG
GCATACAGGACTCAGGATGGGCTGGGCCCCCTGCACTATGGAGTCTGCTCCACGTGGCTA
AGCCAGCTCAAGCCCGGAGACCCTGTGCCCTGCTTCATCCGGGGGGCTCCCTCCTTCCGG
CTGCCACCCGATCCCAGCTTGCCCTGCATCCTGGTGGGTCCAGGCACTGGCATTGCCCCC
TTCCGGGGATTCTGGCAGGAGCGGCTGCATGACATTGAGAGCAAAGGGCTGCAGCCCACT
CCCATGACTTTGGTGTTCGGCTGCCGATGCTCCCAACTTGACCATCTCTACCGCGACGAG
GTGCAGAACGCCCAGCAGCGCGGGGTGTTTGGCCGAGTCCTCACCGCCTTCTCCCGGGAA
CCTGACAACCCCAAGACCTACGTGCAGGACATCCTGAGGACGGAGCTGGCTGCGGAGGTG
CACCGCGTGCTGTGCCTCGAGCGGGGCCACATGTTTGTCTGCGGCGATGTTACCATGGCA
ACCAACGTCCTGCAGACCGTGCAGCGCATCCTGGCGACGGAGGGCGACATGGAGCTGGAC
GAGGCCGGCGACGTCATCGGCGTGCTGCGGGATCAGCAACGCTACCACGAAGACATTTTC
GGGCTCACGCTGCGCACCCAGGAGGTGACAAGCCGCATACGCACCCAGAGCTTTTCCTTG
CAGGAGCGTCAGTTGCGGGGCGCAGTGCCCTGGGCGTTCGACCCTCCCGGCTCAGACACC
AACAGCCCCTGA

# Macromolecular_Interacting_Partner_35_GenBank_ID_Gene:
M93718

# Macromolecular_Interacting_Partner_35_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_35_Locus:
7q36

# Macromolecular_Interacting_Partner_35_SNPs:
rs3918234; rs3918232; rs1799983; rs3918201; rs3918166; rs2566514; rs9282804; rs34967063; rs3918233; rs35281220; rs1549758; rs9282803; rs3918163; rs1800779; rs3918226; rs3918159; rs3918160; rs2243311; rs3918162; rs2070744; rs3918225; rs1800783; rs3918155; rs3918158; rs3918157; rs3918156; rs3918161; rs1808593; rs743507; rs1008140; rs3793341; rs3918196; rs3730002; rs3730003; rs3918188; rs2566511; rs891511; rs3918177; rs3730305; rs3730009; rs867225; rs3918182; rs1007311; rs3834873; rs2853792; rs3918192; rs3918227; rs3918175; rs3918171; rs1800782; rs3918187; rs2853795; rs3918205; rs3918176; rs3918202; rs1541861; rs3918178; rs753482; rs3918204; rs3793342; rs3918174; rs3918167; rs3730010; rs1800781; rs3918203; rs1800780; rs3918198; rs3918180; rs3918194; rs3918184; rs891512; rs3729625; rs743506; rs3918181; rs3918190; rs3918228; rs3918172; rs3918230; rs3918169; rs3918191; rs3730001; rs2853796; rs3918186; rs3918170; rs3918165; rs3918183; rs34919745; rs3730006; rs34372288; rs35795287; rs3918193; rs34554797; rs3918179; rs3918164; rs13305982; rs3918197; rs3918229; rs2243310; rs3918231; rs3918189; rs3918173; rs3918168; rs3918195; rs3918199; rs3918185; rs3918200; rs11771443; rs41377046; rs6947833; rs7792133; rs41508746; rs11552661; rs2566519; rs34417010; rs2566516; rs35886277; rs11371169; rs35480369; rs33915751; rs3730306; rs2566513; rs11974098; rs2566508; rs13305984; rs2566512; rs13311166; rs13310774; rs3730007; rs7776461; rs2853798; rs13305985; rs2853791; rs34110189; rs35771718; rs41385244; rs2853800; rs2566515; rs34833695; rs41490944; rs1799984; rs13310854; rs10539416; rs2566509; rs2566506; rs28763995; rs6969597; rs41322052; rs2853797; rs2853794; rs2566510; rs10539415; rs10255980; rs28763996; rs41408449; rs13310763; rs2566507; rs41394247; rs10595051; rs4725985; rs34617549; rs3828997; rs2853793; rs34204527; rs10531586; rs10265237; rs10276930; rs10277237; rs1064353; rs1077872; rs12666088; rs12703107; rs13307588; rs2373929; rs2373961; rs2373962; rs2566518; rs3134740; rs3730011; rs3730012; rs3800787; rs3918207; rs3918211; rs3918212; rs3918215; rs3918218; rs3918220; rs4496877; rs6951150; rs933163

# Macromolecular_Interacting_Partner_35_General_References:
1378832; 1379542; 7688726; 7509596; 7519987; 7514568; 7475956; 10074942; 12437348; 9737779

# Macromolecular_Interacting_Partner_35_References:
16651461; 16781462; 16937444; 17070516

# Macromolecular_Interacting_Partner_36_ID:
8268

# Macromolecular_Interacting_Partner_36_Name:
Rap guanine nucleotide exchange factor 3

# Macromolecular_Interacting_Partner_36_Synonyms:
cAMP-regulated guanine nucleotide exchange factor I; cAMP-GEFI; Exchange factor directly activated by cAMP 1; Epac 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP

# Macromolecular_Interacting_Partner_36_Gene_Name:
RAPGEF3

# Macromolecular_Interacting_Partner_36_Protein_Sequence:
>Rap guanine nucleotide exchange factor 3
MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGR
QLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE
GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALR
KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS
WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF
NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE
AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKR
QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLEN
GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASV
REVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELI
PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA
NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLS
NSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM
TFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARI
STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP

# Macromolecular_Interacting_Partner_36_Number_of_Residues:
881

# Macromolecular_Interacting_Partner_36_Molecular_Weight:
99354

# Macromolecular_Interacting_Partner_36_Theoretical_pI:
7.78

# Macromolecular_Interacting_Partner_36_GO_Classification:
>>>
Function:  GTPase regulator activity
Function:  small GTPase regulator activity
Function:  guanyl-nucleotide exchange factor activity
Function:  enzyme regulator activity
Function:  kinase regulator activity
Function:  protein kinase regulator activity
Function:  cAMP-dependent protein kinase regulator activity
 ||
>>>
Process:  small GTPase mediated signal transduction
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  protein complex
Component:  unlocalized protein complex
Component:  cAMP-dependent protein kinase complex

# Macromolecular_Interacting_Partner_36_General_Function:
Signal transduction mechanisms 

# Macromolecular_Interacting_Partner_36_Specific_Function:
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP

# Macromolecular_Interacting_Partner_36_Pathway:
Not Available

# Macromolecular_Interacting_Partner_36_Reaction:
Not Available

# Macromolecular_Interacting_Partner_36_Pfam_Domain_Function:
PF00027:cNMP_binding;
PF00610:DEP;
PF00617:RasGEF;
PF00618:RasGEF_N

# Macromolecular_Interacting_Partner_36_Signals:
None

# Macromolecular_Interacting_Partner_36_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_36_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_36_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_36_GenBank_ID_Protein:
3978531

# Macromolecular_Interacting_Partner_36_SwissProt_ID:
RPGF3_HUMAN (O95398)

# Macromolecular_Interacting_Partner_36_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_36_Genecard_id:
RAPGEF3

# Macromolecular_Interacting_Partner_36_Geneatlas_id:
RAPGEF3

# Macromolecular_Interacting_Partner_36_hgnc_id:
HGNC:16629

# Macromolecular_Interacting_Partner_36_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_36_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_36_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_36_Subcellular_Location:
Intracytoplasmic membrane

# Macromolecular_Interacting_Partner_36_Gene_Sequence:
>2646 bp
ATGGTGTTGAGAAGGATGCACCGGCCCCGAAGCTGCTCCTACCAGCTGCTGCTGGAGCAC
CAGCGTCCGAGCTGCATCCAGGGGCTGCGCTGGACACCACTCACCAACAGCGAGGAGTCC
CTGGATTTCAGCGAGAGCCTGGAGCAGGCCTCCACAGAGCGGGTGCTCAGGGCTGGGAGG
CAGCTGCATCGGCATCTGCTGGCCACCTGCCCAAACCTCACCCGAGACCGGAAGTACCAC
CTTAGGCTCTATCGGCAGTGCTGCTCTGGCCGGGAGCTGGTGGATGGGATCTTGGCCCTG
GGACTTGGGGTCCATTCCCGGAGCCAAGTTGTGGGAATCTGCCAGGTGCTGCTGGATGAA
GGTGCCCTCTGCCATGTGAAACACGACTGGGCCTTCCAGGACCGAGATGCCCAATTCTAC
CGGTTCCCCGGGCCCGAGCCCGAGCCCGTGGGAACTCATGAGATGGAGGAGGAGTTGGCC
GAAGCTGTGGCCCTGCTCTCCCAGCGGGGGCCTGACGCCCTGCTCACTGTGGCACTTCGA
AAGCCCCCAGGTCAGCGCACGGATGAAGAGCTGGACCTCATCTTTGAGGAGCTGCTGCAC
ATCAAGGCTGTGGCCCACCTCTCCAACTCGGTGAAGCGAGAATTAGCGGCTGTTCTGCTC
TTTGAACCACACAGCAAGGCAGGGACCGTGTTGTTCAGCCAGGGGGACAAGGGCACTTCG
TGGTACATTATCTGGAAGGGATCTGTCAACGTGGTGACCCATGGCAAGGGGCTGGTGACC
ACCCTGCATGAGGGAGATGATTTTGGACAGCTGGCTCTGGTGAATGATGCACCCCGGGCA
GCCACCATCATCCTGCGAGAAGACAACTGTCATTTCCTGCGTGTGGACAAGCAGGACTTC
AACCGTATCATCAAGGATGTGGAGGCAAAGACCATGCGGCTGGAAGAACATGGCAAAGTG
GTGCTGGTGCTGGAGAGAGCCTCTCAGGGCGCCGGCCCTTCCCGACCCCCAACCCCAGGC
AGGAACCGGTATACAGTGATGTCTGGCACCCCAGAGAAGATCCTAGAGCTTCTGTTGGAG
GCCATGGGACCAGATTCCAGTGCTCATGACCCAACAGAGACATTCCTCAGCGACTTCCTC
CTGACCCACAGGGTCTTCATGCCCAGCGCCCAACTCTGCGCTGCCCTTCTGCACCACTTC
CATGTGGAGCCTGCGGGTGGCAGCGAGCAGGAGCGCAGCACCTACGTCTGCAACAAGAGG
CAGCAGATCTTGCGGCTGGTCAGCCAGTGGGTGGCCCTGTATGGCTCCATGCTCCACACT
GACCCTGTGGCCACCAGCTTCCTCCAGAAACTCTCAGACCTGGTGGGCAGGGACACCCGA
CTCAGCAACCTGCTGAGGGAGCAGTGGCCAGAGAGGCGGCGATGCCACAGGTTGGAGAAT
GGCTGTGGGAATGCATCTCCTCAGATGAAGGCCCGGAACTTGCCTGTTTGGCTCCCCAAC
CAGGACGAGCCCCTTCCTGGCAGCAGCTGTGCCATCCAAGTTGGGGATAAAGTCCCCTAT
GACATCTGCCGGCCAGACCACTCAGTGTTGACCCTGCAGCTGCCTGTGACAGCCTCCGTG
AGAGAGGTGATGGCAGCGTTGGCCCAGGAGGATGGCTGGACCAAGGGGCAGGTGCTGGTG
AAGGTCAATTCTGCAGGTGATGCCATTGGCCTGCAGCCAGATGCCCGTGGTGTGGCCACA
TCTCTGGGGCTCAATGAGCGTCTCTTTGTTGTCAACCCACAGGAAGCGCATGAGCTGATC
CCACACCCTGACCAGCTGGGGCCCACTGTGGGCTCTGCTGAGGGGCTGGACCTGGTGAGT
GCCAAGGACCTGGCAGGCCAGCTGACGGACCACGACTGGAGCCTCTTCAACAGTATCCAC
CAGGTGGAGCTGATCCACTATGTGCTGGGCCCCCAGCATCTGCGGGATGTCACCACCGCC
AACCTGGAGCGCTTCATGCGCCGCTTCAATGAGCTGCAGTACTGGGTGGCCACCGAGCTG
TGTCTCTGCCCCGTGCCCGGCCCCCGGGCCCAGCTGCTCAGGAAGTTCATTAAGCTGGCG
GCCCACCTCAAGGAGCAGAAGAATCTCAATTCCTTCTTTGCCGTCATGTTTGGCCTCAGC
AACTCGGCCATCAGCCGCCTAGCCCACACCTGGGAGCGGCTGCCCCACAAAGTCCGGAAG
CTGTACTCCGCCCTCGAGAGGCTGCTGGATCCCTCATGGAACCACCGGGTATACCGACTG
GCCCTCGCCAAGCTCTCCCCTCCTGTCATCCCCTTCATGCCCCTTCTTCTCAAAGACATG
ACCTTCATTCATGAGGGAAACCACACACTAGTGGAGAATCTCATCAACTTTGAGAAGATG
AGAATGATGGCCAGAGCCGCGCGGATGCTGCACCACTGCCGAAGCCACAACCCTGTGCCT
CTCTCACCACTCAGAAGCCGAGTTTCCCACCTCCACGAGGACAGCCAGGTGGCGAGGATT
TCCACATGCTCGGAGCAGTCCCTGAGCACCCGGAGTCCAGCCAGCACCTGGGCTTATGTC
CAGCAGCTGAAGGTCATTGACAACCAGCGGGAACTCTCCCGCCTCTCCCGAGAGCTGGAG
CCATGA

# Macromolecular_Interacting_Partner_36_GenBank_ID_Gene:
AF103905

# Macromolecular_Interacting_Partner_36_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_36_Locus:
12q13.1

# Macromolecular_Interacting_Partner_36_SNPs:
rs2016123; rs12422983; rs11168230; rs2239189; rs757286; rs2072117; rs10875686; rs757279; rs2238142; rs1018939; rs7963444; rs2072115; rs11615078; rs12818212; rs12423645; rs11168224; rs2074534; rs10875687; rs2074533; rs7308119; rs2239190; rs4768162; rs11168225; rs11168223; rs757280; rs12298639; rs4141223; rs11168220; rs2238144; rs734706; rs10875689; rs7957537; rs2238143; rs7977774; rs12817548; rs11168227; rs2072116; rs757281; rs757287; rs11168219; rs10875685; rs11168228; rs12424297; rs11168216; rs10875688; rs7308032; rs2240079; rs1548518; rs757282; rs3809316; rs7134842; rs12426774; rs10875690; rs7955143; rs7138076; rs12813049; rs11168215; rs7300107; rs11168214; rs11542093; rs10750; rs873622; rs36006818; rs35340931; rs34986805; rs35703007; rs12828238; rs2074535; rs11168226; rs34147855; rs2074530; rs7487203; rs12305334; rs757285; rs11168229; rs11612229; rs1476575; rs11168221; rs4768843; rs34633930; rs34467472; rs36014314; rs11168222; rs5798039; rs34739581; rs11370159; rs1476574; rs3840800; rs1548517; rs3840799; rs12581408; rs11433316; rs12818990; rs12821281; rs7138461; rs12815324; rs33931304; rs12813783; rs12813791; rs25587; rs35003781; rs10747521; rs10875683; rs11168213; rs11168231; rs11168232; rs11830037; rs11830537; rs12426178; rs12580458; rs12810487; rs12812960; rs12815308; rs12815462; rs12818241; rs12827114; rs1859256; rs2010734; rs2240080; rs2285830; rs2285831; rs35784744; rs3764013; rs3764015; rs4768842; rs7135791; rs726590; rs7397585; rs7397928; rs7399189; rs7484827; rs7488942; rs757283; rs757284; rs763986; rs7965816; rs877195; rs877196; rs877197; rs877198; rs879177; rs879178; rs879179; rs886431

# Macromolecular_Interacting_Partner_36_General_References:
9853756; 9856955; 10777494

# Macromolecular_Interacting_Partner_36_References:
16613879; 16728394; 16751380; 16856834

# Macromolecular_Interacting_Partner_37_ID:
8405

# Macromolecular_Interacting_Partner_37_Name:
Hypothetical protein

# Macromolecular_Interacting_Partner_37_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_37_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_37_Protein_Sequence:
>Hypothetical protein
MLFKAYMYLNEGQKLLKTLKKDKSWSQTFESATFYSLKGEVCFNMGQIVLAKKMLRKALK
LLNRIFPYNLISLFLHIHVEKNRHFHYVNRQAQESPPPGKKRLAQLYRQTVCLSLLWRIY
SYSYLFHCKYYAHLAVMMQMNTALETQNCFQIIKAYLDYSLYHHLAGYKGVWFKYEVMAM
EHIFNLPLKGEGIEIVAYVAETLVFNKLIMGHLDLAIELGSRALQMWALLQNPNRHYQSL
CRLSRCLLLNSRYPQLIQVLGRLWELSVTQEHIFSKAFFYFVCLDILLYSGFVYRTFEEC
LEFIHQYENNRILKFHSGLLLGLYSSVAIWECEAGVGRRLHTSRDPGMPDFRNGTTFTNF
PIELKIFCQEEP

# Macromolecular_Interacting_Partner_37_Number_of_Residues:
372

# Macromolecular_Interacting_Partner_37_Molecular_Weight:
43901

# Macromolecular_Interacting_Partner_37_Theoretical_pI:
9.26

# Macromolecular_Interacting_Partner_37_GO_Classification:
>>>
Function:  binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_37_General_Function:
Not Available

# Macromolecular_Interacting_Partner_37_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_37_Pathway:
Not Available

# Macromolecular_Interacting_Partner_37_Reaction:
Not Available

# Macromolecular_Interacting_Partner_37_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_37_Signals:
None

# Macromolecular_Interacting_Partner_37_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_37_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_37_EC_Link:
EC 4.6.1.1

# Macromolecular_Interacting_Partner_37_GenBank_ID_Protein:
4153951

# Macromolecular_Interacting_Partner_37_SwissProt_ID:
O95558_HUMAN (O95558)

# Macromolecular_Interacting_Partner_37_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_37_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_37_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_37_hgnc_id:
Not Available

# Macromolecular_Interacting_Partner_37_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_37_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_37_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_37_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_37_Gene_Sequence:
>1119 bp
ATGCTGTTCAAGGCATACATGTATTTGAATGAAGGACAGAAGTTGCTAAAAACTCTCAAG
AAGGACAAATCTTGGAGCCAGACATTTGAGTCTGCCACCTTTTACAGCCTCAAAGGTGAG
GTCTGTTTCAATATGGGCCAGATAGTGCTTGCCAAGAAAATGCTGAGGAAGGCACTGAAG
CTCCTCAACCGAATCTTTCCTTACAACTTAATCTCCTTGTTTCTCCATATCCATGTCGAG
AAAAACAGACACTTTCATTATGTGAATCGGCAGGCCCAAGAGAGCCCACCTCCAGGGAAG
AAGAGGCTGGCACAACTTTACCGGCAAACTGTCTGCCTTTCCTTGCTGTGGCGCATCTAT
AGCTACAGTTATCTTTTTCACTGCAAGTATTATGCCCACCTGGCAGTTATGATGCAAATG
AATACTGCACTGGAAACTCAAAATTGTTTCCAGATCATTAAGGCTTACCTAGACTATTCG
CTATACCACCACCTGGCTGGCTACAAAGGTGTGTGGTTCAAATATGAAGTCATGGCCATG
GAGCACATCTTCAACCTCCCCCTGAAAGGCGAGGGCATTGAAATCGTGGCATACGTGGCT
GAGACACTGGTCTTCAACAAGCTCATAATGGGACACCTGGATTTGGCCATTGAGTTAGGC
TCCCGAGCCCTTCAGATGTGGGCACTGCTCCAGAATCCCAACCGACATTATCAGTCCCTC
TGCAGACTTAGCAGATGTCTCCTTCTGAACAGCAGATACCCGCAATTGATCCAGGTGCTG
GGGCGGCTGTGGGAGCTTTCTGTAACACAGGAACACATCTTCAGCAAGGCATTTTTCTAT
TTTGTCTGCTTGGACATCCTGCTTTATTCTGGTTTTGTTTATAGAACATTTGAAGAATGT
TTGGAATTCATACACCAATACGAAAACAACAGAATCCTCAAGTTCCACAGTGGACTCCTC
CTGGGACTTTATTCCTCTGTAGCTATCTGGGAGTGTGAAGCAGGGGTAGGCAGGAGACTA
CACACTTCCAGAGACCCAGGTATGCCAGACTTCAGGAATGGGACAACTTTTACAAATTTT
CCAATAGAGCTAAAAATCTTTTGCCAAGAAGAACCATGA

# Macromolecular_Interacting_Partner_37_GenBank_ID_Gene:
AL035122

# Macromolecular_Interacting_Partner_37_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_37_Locus:
Not Available

# Macromolecular_Interacting_Partner_37_SNPs:
Not Available

# Macromolecular_Interacting_Partner_37_General_References:
Not Available

# Macromolecular_Interacting_Partner_37_References:
16849696; 16855230; 16856834; 16856841

# Macromolecular_Interacting_Partner_38_ID:
8123

# Macromolecular_Interacting_Partner_38_Name:
Renin precursor

# Macromolecular_Interacting_Partner_38_Synonyms:
Angiotensinogenase

# Macromolecular_Interacting_Partner_38_Gene_Name:
REN

# Macromolecular_Interacting_Partner_38_Protein_Sequence:
>Renin precursor
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR

# Macromolecular_Interacting_Partner_38_Number_of_Residues:
406

# Macromolecular_Interacting_Partner_38_Molecular_Weight:
45058

# Macromolecular_Interacting_Partner_38_Theoretical_pI:
7.07

# Macromolecular_Interacting_Partner_38_GO_Classification:
>>>
Function:  pepsin A activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  aspartic-type endopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_38_General_Function:
Not Available

# Macromolecular_Interacting_Partner_38_Specific_Function:
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney

# Macromolecular_Interacting_Partner_38_Pathway:
Not Available

# Macromolecular_Interacting_Partner_38_Reaction:
Cleavage of Leu-|- bond in angiotensinogen to generate angiotensin I

# Macromolecular_Interacting_Partner_38_Pfam_Domain_Function:
PF07966:A1_Propeptide;
PF00026:Asp

# Macromolecular_Interacting_Partner_38_Signals:
1-23

# Macromolecular_Interacting_Partner_38_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_38_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_38_EC_Link:
EC 3.4.23.15

# Macromolecular_Interacting_Partner_38_GenBank_ID_Protein:
190994

# Macromolecular_Interacting_Partner_38_SwissProt_ID:
RENI_HUMAN (P00797)

# Macromolecular_Interacting_Partner_38_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_38_Genecard_id:
REN

# Macromolecular_Interacting_Partner_38_Geneatlas_id:
REN

# Macromolecular_Interacting_Partner_38_hgnc_id:
HGNC:9958

# Macromolecular_Interacting_Partner_38_PDB_ID:
1BBS

# Macromolecular_Interacting_Partner_38_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_38_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_38_Subcellular_Location:
Secreted protein. Membrane. Note=Associated to membranes via binding to ATP6AP2

# Macromolecular_Interacting_Partner_38_Gene_Sequence:
>1221 bp
ATGGATGGATGGAGAAGGATGCCTCGCTGGGGACTGCTGCTGCTGCTCTGGGGCTCCTGT
ACCTTTGGTCTCCCGACAGACACCACCACCTTTAAACGGATCTTCCTCAAGAGAATGCCC
TCAATCCGAGAAAGCCTGAAGGAACGAGGTGTGGACATGGCCAGGCTTGGTCCCGAGTGG
AGCCAACCCATGAAGAGGCTGACACTTGGCAACACCACCTCCTCCGTGATCCTCACCAAC
TACATGGACACCCAGTACTATGGCGAGATTGGCATCGGCACCCCACCCCAGACCTTCAAA
GTCGTCTTTGACACTGGTTCGTCCAATGTTTGGGTGCCCTCCTCCAAGTGCAGCCGTCTC
TACACTGCCTGTGTGTATCACAAGCTCTTCGATGCTTCGGATTCCTCCAGCTACAAGCAC
AATGGAACAGAACTCACCCTCCGCTATTCAACAGGGACAGTCAGTGGCTTTCTCAGCCAG
GACATCATCACCGTGGGTGGAATCACGGTGACACAGATGTTTGGAGAGGTCACGGAGATG
CCCGCCTTACCCTTCATGCTGGCCGAGTTTGATGGGGTTGTGGGCATGGGCTTCATTGAA
CAGGCCATTGGCAGGGTCACCCCTATCTTCGACAACATCATCTCCCAAGGGGTGCTAAAA
GAGGACGTCTTCTCTTTCTACTACAACAGAGATTCCGAGAATTCCCAATCGCTGGGAGGA
CAGATTGTGCTGGGAGGCAGCGACCCCCAGCATTACGAAGGGAATTTCCACTATATCAAC
CTCATCAAGACTGGTGTCTGGCAGATTCAAATGAAGGGGGTGTCTGTGGGGTCATCCACC
TTGCTCTGTGAAGACGGCTGCCTGGCATTGGTAGACACCGGTGCATCCTACATCTCAGGT
TCTACCAGCTCCATAGAGAAGCTCATGGAGGCCTTGGGAGCCAAGAAGAGGCTGTTTGAT
TATGTCGTGAAGTGTAACGAGGGCCCTACACTCCCCGACATCTCTTTCCACCTGGGAGGC
AAAGAATACACGCTCACCAGCGCGGACTATGTATTTCAGGAATCCTACAGTAGTAAAAAG
CTGTGCACACTGGCCATCCACGCCATGGATATCCCGCCACCCACTGGACCCACCTGGGCC
CTGGGGGCCACCTTCATCCGAAAGTTCTACACAGAGTTTGATCGGCGTAACAACCGCATT
GGCTTCGCCTTGGCCCGCTGA

# Macromolecular_Interacting_Partner_38_GenBank_ID_Gene:
L00073

# Macromolecular_Interacting_Partner_38_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_38_Locus:
1q32

# Macromolecular_Interacting_Partner_38_SNPs:
rs11571117; rs11571098; rs11571083; rs5705; rs11571120; rs11571124; rs7521667; rs2887284; rs1464816; rs1917539; rs6693954; rs5706; rs11571123; rs10900555; rs6676670; rs10900557; rs11571079; rs11240688; rs11571108; rs10900556; rs2368564; rs11571104; rs11571102; rs5707; rs11571078; rs11571107; rs11571114; rs11571091; rs11571119; rs11571082; rs11571088; rs11571077; rs11571105; rs11240686; rs11571106; rs3215332; rs3795574; rs11571092; rs11571111; rs3795575; rs11571112; rs2177695; rs3730102; rs11240689; rs11571086; rs6665480; rs11571113; rs3730104; rs11571084; rs3730103; rs11571118; rs11571100; rs11240687; rs11571087; rs2272237; rs6674952; rs11571110; rs11571085; rs11571103; rs11571101; rs11571121; rs11240685; rs11571109; rs11571080; rs11571076; rs11578877; rs11571081; rs11571115; rs11571090; rs6676458; rs11571122; rs11571116; rs6681776; rs6668858; rs6682082; rs11571096; rs11571073; rs11571075; rs11571097; rs11571074; rs11571093; rs11571128; rs11571126; rs11571095; rs11571094; rs11571127; rs11571125; rs6704321; rs11542630; rs34069565; rs1126947; rs1042875; rs5704; rs1042874; rs11799601; rs3730101; rs28580264; rs13306600; rs11284490; rs28730746; rs13306601; rs28417178; rs4439406; rs34296392; rs3839003; rs35241727; rs5708; rs4396166; rs35201130; rs34481638; rs11571099; rs11581713; rs28730747; rs2177694; rs10494849; rs1106778; rs16853059; rs16853062; rs16853072; rs1917542; rs1997034; rs2293337; rs3795576; rs6688425; rs6702587; rs7539596; rs7548714; rs940651; rs940652

# Macromolecular_Interacting_Partner_38_General_References:
6324167; 3530608; 6391881; 6138751; 3032746; 2540188; 3516796; 2016271; 12045255; 2493678; 1608447

# Macromolecular_Interacting_Partner_38_References:
17068292; 17088449

# Macromolecular_Interacting_Partner_39_ID:
8005

# Macromolecular_Interacting_Partner_39_Name:
Proto-oncogene protein c-fos

# Macromolecular_Interacting_Partner_39_Synonyms:
Cellular oncogene fos; G0/G1 switch regulatory protein 7

# Macromolecular_Interacting_Partner_39_Gene_Name:
FOS

# Macromolecular_Interacting_Partner_39_Protein_Sequence:
>Protooncogene protein cfos
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANF
IPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRA
QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ
TEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT
LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYA
ADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRK
GSSSNEPSSDSLSSPTLLAL

# Macromolecular_Interacting_Partner_39_Number_of_Residues:
380

# Macromolecular_Interacting_Partner_39_Molecular_Weight:
40696

# Macromolecular_Interacting_Partner_39_Theoretical_pI:
4.50

# Macromolecular_Interacting_Partner_39_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_39_General_Function:
Not Available

# Macromolecular_Interacting_Partner_39_Specific_Function:
Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, c-fos and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation

# Macromolecular_Interacting_Partner_39_Pathway:
Not Available

# Macromolecular_Interacting_Partner_39_Reaction:
Not Available

# Macromolecular_Interacting_Partner_39_Pfam_Domain_Function:
PF07716:bZIP_2

# Macromolecular_Interacting_Partner_39_Signals:
None

# Macromolecular_Interacting_Partner_39_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_39_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_39_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_39_GenBank_ID_Protein:
29904

# Macromolecular_Interacting_Partner_39_SwissProt_ID:
FOS_HUMAN (P01100)

# Macromolecular_Interacting_Partner_39_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_39_Genecard_id:
FOS

# Macromolecular_Interacting_Partner_39_Geneatlas_id:
FOS

# Macromolecular_Interacting_Partner_39_hgnc_id:
HGNC:3796

# Macromolecular_Interacting_Partner_39_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_39_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_39_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_39_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_39_Gene_Sequence:
>1143 bp
ATGATGTTCTCGGGCTTCAACGCAGACTACGAGGCGTCATCCTCCCGCTGCAGCAGCGCG
TCCCCGGCCGGGGATAGCCTCTCTTACTACCACTCACCCGCAGACTCCTTCTCCAGCATG
GGCTCGCCTGTCAACGCGCAGGACTTCTGCACGGACCTGGCCGTCTCCAGTGCCAACTTC
ATTCCCACGGTCACTGCCATCTCGACCAGTCCGGACCTGCAGTGGCTGGTGCAGCCCGCC
CTCGTCTCCTCTGTGGCCCCATCGCAGACCAGAGCCCCTCACCCTTTCGGAGTCCCCGCC
CCCTCCGCTGGGGCTTACTCCAGGGCTGGCGTTGTGAAGACCATGACAGGAGGCCGAGCG
CAGAGCATTGGCAGGAGGGGCAAGGTGGAACAGTTATCTCCAGAAGAAGAAGAGAAAAGG
AGAATCCGAAGGGAAAGGAATAAGATGGCTGCAGCCAAATGCCGCAACCGGAGGAGGGAG
CTGACTGATACACTCCAAGCGGAGACAGACCAACTAGAAGATGAGAAGTCTGCTTTGCAG
ACCGAGATTGCCAACCTGCTGAAGGAGAAGGAAAAACTAGAGTTCATCCTGGCAGCTCAC
CGACCTGCCTGCAAGATCCCTGATGACCTGGGCTTCCCAGAAGAGATGTCTGTGGCTTCC
CTTGATCTGACTGGGGGCCTGCCAGAGGTTGCCACCCCGGAGTCTGAGGAGGCCTTCACC
CTGCCTCTCCTCAATGACCCTGAGCCCAAGCCCTCAGTGGAACCTGTCAAGAGCATCAGC
AGCATGGAGCTGAAGACCGAGCCCTTTGATGACTTCCTGTTCCCAGCATCATCCAGGCCC
AGTGGCTCTGAGACAGCCCGCTCCGTGCCAGACATGGACCTATCTGGGTCCTTCTATGCA
GCAGACTGGGAGCCTCTGCACAGTGGCTCCCTGGGGATGGGGCCCATGGCCACAGAGCTG
GAGCCCCTGTGCACTCCGGTGGTCACCTGTACTCCCAGCTGCACTGCTTACACGTCTTCC
TTCGTCTTCACCTACCCCGAGGCTGACTCCTTCCCCAGCTGTGCAGCTGCCCACCGCAAG
GGCAGCAGCAGCAATGAGCCTTCCTCTGACTCGCTCAGCTCACCCACGCTGCTGGCCCTG
TGA

# Macromolecular_Interacting_Partner_39_GenBank_ID_Gene:
V01512

# Macromolecular_Interacting_Partner_39_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_39_Locus:
14q24.3

# Macromolecular_Interacting_Partner_39_SNPs:
rs2229024; rs1046117; rs4645857; rs7101; rs2239615; rs4645855; rs4645856; rs3216792; rs35706183; rs4645853; rs1063169; rs4645854; rs35586383; rs932257; rs2234706; rs4645850; rs4645859; rs4645852; rs4645849; rs1046283; rs3180688; rs4645858; rs14371; rs11354110; rs35423373; rs4645861; rs4645848; rs10142078; rs4645860; rs4645847; rs4645851; rs1005367; rs1009392; rs10133192; rs10133595; rs10144025; rs11159131; rs1569328; rs17103109; rs3742769; rs3742770; rs4645869; rs4645870; rs4645875; rs4645876; rs4645877; rs4903301; rs4903304; rs6574222; rs7146378; rs7154366; rs926113

# Macromolecular_Interacting_Partner_39_General_References:
6574479; 2516827; 12508121; 1658710; 2511004; 7816143

# Macromolecular_Interacting_Partner_39_References:
16672767; 16799259; 16845490; 16887909

# Macromolecular_Interacting_Partner_40_ID:
8444

# Macromolecular_Interacting_Partner_40_Name:
Transforming growth factor beta-1 precursor

# Macromolecular_Interacting_Partner_40_Synonyms:
TGF-beta-1[Contains: Latency-associated peptide; LAP]

# Macromolecular_Interacting_Partner_40_Gene_Name:
TGFB1

# Macromolecular_Interacting_Partner_40_Protein_Sequence:
>Transforming growth factor beta1 precursor
MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI
YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR
YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT
TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI
DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA
LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

# Macromolecular_Interacting_Partner_40_Number_of_Residues:
390

# Macromolecular_Interacting_Partner_40_Molecular_Weight:
44342

# Macromolecular_Interacting_Partner_40_Theoretical_pI:
8.63

# Macromolecular_Interacting_Partner_40_GO_Classification:
>>>
Function:  growth factor activity
Function:  signal transducer activity
Function:  receptor binding
Function:  transforming growth factor beta receptor binding
 ||
>>>
Process:  growth
Process:  cell growth
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_40_General_Function:
Not Available

# Macromolecular_Interacting_Partner_40_Specific_Function:
Multifunctional protein that control proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGFB1 and essentially all of them have specific receptors for this protein. It regulates the actions of many other growth factors and determines a positive or negative direction of their effects. It plays an important role in bone remodelling. It is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts

# Macromolecular_Interacting_Partner_40_Pathway:
Not Available

# Macromolecular_Interacting_Partner_40_Reaction:
Not Available

# Macromolecular_Interacting_Partner_40_Pfam_Domain_Function:
PF00019:TGF_beta;
PF00688:TGFb_propeptide

# Macromolecular_Interacting_Partner_40_Signals:
1-29

# Macromolecular_Interacting_Partner_40_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_40_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_40_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_40_GenBank_ID_Protein:
1212989

# Macromolecular_Interacting_Partner_40_SwissProt_ID:
TGFB1_HUMAN (P01137)

# Macromolecular_Interacting_Partner_40_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_40_Genecard_id:
TGFB1

# Macromolecular_Interacting_Partner_40_Geneatlas_id:
TGFB1

# Macromolecular_Interacting_Partner_40_hgnc_id:
HGNC:11766

# Macromolecular_Interacting_Partner_40_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_40_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_40_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_40_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_40_Gene_Sequence:
>355 bp
ATGCCGCCCTCCGGGCTGCGGCTGCTGCTGCTGCTGCTACCGCTGCTGTGGCTACTGGTG
CTGACGCCTGGCCGGCCGGCCGCGGGACTATCCACCTGCAAGACTATCGACATGGAGCTG
GTGAAGCGGAAGCGCATCGAGGCCATCCGCGGCCAGATCCTGTCCAAGCTGCGGCTCGCC
AGCCCCCCGAGCCAGGGGGAGGTGCCGCCCGGCCCGCTGCCCGAGGCCGTGCTCGCCCTG
TACAACAGCACCCGCGACCGGGTGGCCGGGGAGAGTGCAGAACCGGAGCCCGAGCCTGAG
GCCGACTACTACGCCAAGGAGGTCACCCGCGTGCTAATGGTGGAAACCCACAACG

# Macromolecular_Interacting_Partner_40_GenBank_ID_Gene:
X05839

# Macromolecular_Interacting_Partner_40_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_40_Locus:
19q13.2|19q13.1

# Macromolecular_Interacting_Partner_40_SNPs:
rs1982073; rs1800472; rs1800471; rs9282871; rs11466316; rs11466315; rs2241717; rs7408955; rs2278422; rs13306709; rs7258445; rs2288873; rs747857; rs8110090; rs11466329; rs2288874; rs11466347; rs2241716; rs8179181; rs8102501; rs11466345; rs8105161; rs6508976; rs4803455; rs1989457; rs11466338; rs10405403; rs8108052; rs2241715; rs11466335; rs11466357; rs12461895; rs6508975; rs11466337; rs11466351; rs11466344; rs12462166; rs11466331; rs11466341; rs11466324; rs11466359; rs11466318; rs10420084; rs11466356; rs11466343; rs11466321; rs1549934; rs10406816; rs11466334; rs11466349; rs10416269; rs11466353; rs8179182; rs13447341; rs35383147; rs11466358; rs11551225; rs11551223; rs12977601; rs12985978; rs13306707; rs11551226; rs36102838; rs13306706; rs35025994; rs12977628; rs13306708; rs11466354; rs11466330; rs7249191; rs35169655; rs11466327; rs11466355; rs8102918; rs9749548; rs12983775; rs5828100; rs3061187; rs41275752; rs12979815; rs35276753; rs35019416; rs3061188; rs2288875; rs3061192; rs5828102; rs28730295; rs12976890; rs35312206; rs11466333; rs33950017; rs11403932; rs11466340; rs11331966; rs3061190; rs2014015; rs11466328; rs11672143; rs35976994; rs5828101; rs11466346; rs10418010; rs8108632; rs35676663; rs35197353; rs11466352; rs11307639; rs11347492; rs12980944; rs11367425; rs36050346; rs34368921; rs8103575; rs11466350; rs11466342; rs12978333; rs11466320; rs11466348; rs41333448; rs34971127; rs11673275; rs11466336; rs28769597; rs11466339; rs5828099; rs10406316; rs12976219; rs34233206; rs10417924; rs1054797; rs11083616; rs11304; rs11668109; rs11668308; rs11669342; rs11879777; rs12980298; rs12980942; rs12981053; rs12983047; rs16959007; rs1800468; rs1800469; rs1800820; rs1982072; rs2241712; rs2241713; rs2241714; rs2241718; rs2241719; rs2241720; rs34088631; rs35135271; rs3810173; rs4803454; rs6957; rs7257310; rs7257742

# Macromolecular_Interacting_Partner_40_General_References:
3470709; 3861940; 8471846; 2982829; 3162913; 9150447; 11746498; 8424942; 8424943; 8679613; 9783545; 10973241; 11062463; 12202987; 12493741; 12843182

# Macromolecular_Interacting_Partner_40_References:
16959941

# Macromolecular_Interacting_Partner_41_ID:
8080

# Macromolecular_Interacting_Partner_41_Name:
Beta-nerve growth factor precursor

# Macromolecular_Interacting_Partner_41_Synonyms:
Beta-NGF

# Macromolecular_Interacting_Partner_41_Gene_Name:
NGFB

# Macromolecular_Interacting_Partner_41_Protein_Sequence:
>Betanerve growth factor precursor
MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIA
ARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSK
RSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCR
DPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRR
A

# Macromolecular_Interacting_Partner_41_Number_of_Residues:
241

# Macromolecular_Interacting_Partner_41_Molecular_Weight:
26959

# Macromolecular_Interacting_Partner_41_Theoretical_pI:
10.54

# Macromolecular_Interacting_Partner_41_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_41_General_Function:
Not Available

# Macromolecular_Interacting_Partner_41_Specific_Function:
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons

# Macromolecular_Interacting_Partner_41_Pathway:
Not Available

# Macromolecular_Interacting_Partner_41_Reaction:
Not Available

# Macromolecular_Interacting_Partner_41_Pfam_Domain_Function:
PF00243:NGF

# Macromolecular_Interacting_Partner_41_Signals:
1-18

# Macromolecular_Interacting_Partner_41_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_41_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_41_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_41_GenBank_ID_Protein:
671883

# Macromolecular_Interacting_Partner_41_SwissProt_ID:
NGF_HUMAN (P01138)

# Macromolecular_Interacting_Partner_41_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_41_Genecard_id:
NGFB

# Macromolecular_Interacting_Partner_41_Geneatlas_id:
NGFB

# Macromolecular_Interacting_Partner_41_hgnc_id:
HGNC:7808

# Macromolecular_Interacting_Partner_41_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_41_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_41_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_41_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_41_Gene_Sequence:
>726 bp
ATGTCCATGTTGTTCTACACTCTGATCACAGCTTTTCTGATCGGCATACAGGCGGAACCA
CACTCAGAGAGCAATGTCCCTGCAGGACACACCATCCCCCAAGTCCACTGGACTAAACTT
CAGCATTCCCTTGACACTGCCCTTCGCAGAGCCCGCAGCGCCCCGGCAGCGGCGATAGCT
GCACGCGTGGCGGGGCAGACCCGCAACATTACTGTGGACCCCAGGCTGTTTAAAAAGCGG
CGACTCCGTTCACCCCGTGTGCTGTTTAGCACCCAGCCTCCCCGTGAAGCTGCAGACACT
CAGGATCTGGACTTCGAGGTCGGTGGTGCTGCCCCCTTCAACAGGACTCACAGGAGCAAG
CGGTCATCATCCCATCCCATCTTCCACAGGGGCGAATTCTCGGTGTGTGACAGTGTCAGC
GTGTGGGTTGGGGATAAGACCACCGCCACAGACATCAAGGGCAAGGAGGTGATGGTGTTG
GGAGAGGTGAACATTAACAACAGTGTATTCAAACAGTACTTTTTTGAGACCAAGTGCCGG
GACCCAAATCCCGTTGACAGCGGGTGCCGGGGCATTGACTCAAAGCACTGGAACTCATAT
TGTACCACGACTCACACCTTTGTCAAGGCGCTGACCATGGATGGCAAGCAGGCTGCCTGG
CGGTTTATCCGGATAGATACGGCCTGTGTGTGTGTGCTCAGCAGGAAGGCTGTGAGAAGA
GCCTGA

# Macromolecular_Interacting_Partner_41_GenBank_ID_Gene:
V01511

# Macromolecular_Interacting_Partner_41_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_41_Locus:
1p13.1

# Macromolecular_Interacting_Partner_41_SNPs:
rs6330; rs11466110; rs11466111; rs6325; rs1318345; rs2747058; rs719452; rs2179926; rs2254404; rs2856813; rs910330; rs2239622; rs10776800; rs2254527; rs3811015; rs4332358; rs10776798; rs4454548; rs4839028; rs4073129; rs4076194; rs4839435; rs4146585; rs6678788; rs4839436; rs6326; rs12082544; rs6328; rs6698675; rs7540561; rs6537860; rs4240542; rs7544068; rs4529705; rs7542555; rs4075872; rs11102929; rs2747063; rs10745349; rs7535026; rs10776799; rs2268792; rs6673867; rs4565713; rs4626883; rs2268793; rs4076018; rs2300692; rs6331; rs6686615; rs10858075; rs12402406; rs11466098; rs17540656; rs4573519; rs10858072; rs10489530; rs12060354; rs7516191; rs11466100; rs11102924; rs7530686; rs3730194; rs2856811; rs10776797; rs12026714; rs11102925; rs17033706; rs7513144; rs4298728; rs17033692; rs17033685; rs10442682; rs11102919; rs12067817; rs4382725; rs4567277; rs3738701; rs11102917; rs11466085; rs11102926; rs7544163; rs7523654; rs17033688; rs10858074; rs4634908; rs2300694; rs7520839; rs11466069; rs11466104; rs11466091; rs11466073; rs4240543; rs11466103; rs11466089; rs11466083; rs11466102; rs12026809; rs11102920; rs12145726; rs12048019; rs11466076; rs11102916; rs11466070; rs10442681; rs6678898; rs11466068; rs11466075; rs12061479; rs7415422; rs11466099; rs7555016; rs11466093; rs6658541; rs11466077; rs17033622; rs11466079; rs11466095; rs2300693; rs11466094; rs4623700; rs10858071; rs11466106; rs11466109; rs12058002; rs11466097; rs11466074; rs3811016; rs12061661; rs17033680; rs2300695; rs11466108; rs4644491; rs11102922; rs4406631; rs12058927; rs11466072; rs12091513; rs12060360; rs11466071; rs4298730; rs11466081; rs11466086; rs10858073; rs11466080; rs11102921; rs11102927; rs7536097; rs12760036; rs11102918; rs11466087; rs11466096; rs11466084; rs4320778; rs11584438; rs4348722; rs4456091; rs4839434; rs6329; rs7417254; rs11466088; rs10158276; rs4240544; rs11466082; rs3811014; rs10776801; rs11102930; rs11466113; rs11466066; rs11466063; rs11466065; rs11466062; rs34542615; rs28758211; rs11466112; rs34079702; rs35941329; rs11466092; rs12727497; rs35833423; rs11579116; rs35290932; rs11302114; rs2284830; rs12749420; rs3730184; rs28645283; rs2747059; rs11466090; rs35070942; rs11102923; rs12088144; rs35067920; rs11102928; rs11580846; rs35755250; rs11466107; rs34024301; rs12023088; rs28735771; rs28461336; rs11579131; rs34357271; rs34257515; rs11579114; rs35884898; rs12025459; rs12119346; rs35221274; rs35274060; rs12073677; rs12070188; rs11584424; rs35329343; rs34377570; rs11485078; rs3730215; rs35658308; rs3021067; rs4417063; rs12731678; rs2747061; rs35447405; rs12047130; rs11579133; rs13374803; rs35225488; rs9970214; rs719451; rs7528234; rs2747056; rs2856814; rs10157426; rs12731680; rs11466078; rs2747055; rs35917469; rs35011726; rs35337130; rs35044546; rs17033682; rs28505352; rs34063775; rs2856812; rs35439338; rs11466105; rs34845120; rs11586039; rs34042023; rs35071824; rs34402529; rs2747057; rs11466114; rs35603764; rs11466064; rs11466061; rs11466067; rs34611363; rs3841009; rs10776802; rs10858076; rs10858077; rs10858078; rs11102915; rs11102932; rs11466059; rs11583020; rs11805062; rs11807499; rs12074502; rs12075799; rs12085129; rs12139760; rs12723944; rs1474798; rs1535093; rs1555207; rs17033589; rs17033597; rs17033602; rs17033725; rs2068797; rs2982740; rs2982741; rs2982742; rs3014804; rs4073110; rs4131272; rs4131273; rs4310443; rs4418592; rs4504888; rs4839029; rs4839030; rs4839031; rs6327; rs6656381; rs6657711; rs6676284; rs6678944; rs6691765; rs7416420; rs7523086; rs7523831; rs7532754; rs7544256; rs926781

# Macromolecular_Interacting_Partner_41_General_References:
6688123; 6327169; 2374737; 10322959; 2025430; 10391209

# Macromolecular_Interacting_Partner_41_References:
16627466; 16946588; 16962714; 17059558

# Macromolecular_Interacting_Partner_42_ID:
8249

# Macromolecular_Interacting_Partner_42_Name:
Corticoliberin precursor

# Macromolecular_Interacting_Partner_42_Synonyms:
Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone

# Macromolecular_Interacting_Partner_42_Gene_Name:
CRH

# Macromolecular_Interacting_Partner_42_Protein_Sequence:
>Corticoliberin precursor
MRLPLLVSAGVLLVALLPCPPCRALLSRGPVPGARQAPQHPQPLDFFQPPPQSEQPQQPQ
ARPVLLRMGEEYFLRLGNLNKSPAAPLSPASSLLAGGSGSRPSPEQATANFFRVLLQQLL
LPRRSLDSPAALAERGARNALGGHQEAPERERRSEEPPISLDLTFHLLREVLEMARAEQL
AQQAHSNRKLMEIIGK

# Macromolecular_Interacting_Partner_42_Number_of_Residues:
196

# Macromolecular_Interacting_Partner_42_Molecular_Weight:
21422

# Macromolecular_Interacting_Partner_42_Theoretical_pI:
10.55

# Macromolecular_Interacting_Partner_42_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_42_General_Function:
Not Available

# Macromolecular_Interacting_Partner_42_Specific_Function:
This hormone from hypothalamus regulates the release of corticotropin from pituitary gland

# Macromolecular_Interacting_Partner_42_Pathway:
Not Available

# Macromolecular_Interacting_Partner_42_Reaction:
Not Available

# Macromolecular_Interacting_Partner_42_Pfam_Domain_Function:
PF00473:CRF

# Macromolecular_Interacting_Partner_42_Signals:
1-24

# Macromolecular_Interacting_Partner_42_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_42_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_42_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_42_GenBank_ID_Protein:
35356

# Macromolecular_Interacting_Partner_42_SwissProt_ID:
CRF_HUMAN (P06850)

# Macromolecular_Interacting_Partner_42_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_42_Genecard_id:
CRH

# Macromolecular_Interacting_Partner_42_Geneatlas_id:
CRH

# Macromolecular_Interacting_Partner_42_hgnc_id:
HGNC:2355

# Macromolecular_Interacting_Partner_42_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_42_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_42_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_42_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_42_Gene_Sequence:
>591 bp
ATGCGGCTGCCGCTGCTTGTGTCCGCGGGAGTCCTGCTGGTGGCTCTCCTGCCCTGCCCG
CCATGCAGGGCGCTCCTGAGCCGCGGGCCGGTCCCGGGAGCTCGGCAGGCGCCGCAGCAC
CCTCAGCCCTTGGATTTCTTCCAGCCGCCGCCGCAGTCCGAGCAGCCCCAGCAGCCGCAG
GCTCGGCCGGTCCTGCTCCGCATGGGAGAGGAGTACTTCCTCCGCCTGGGGAACCTCAAC
AAGAGCCCGGCCGCTCCCCTTTCGCCCGCCTCCTCGCTCCTCGCCGGAGGCAGCGGCAGC
CGCCCTTCGCCGGAACAGGCGACCGCCAACTTTTTCCGCGTGTTGCTGCAGCAGCTGCTG
CTGCCTCGGCGCTCGCTCGACAGCCCCGCGGCTCTCGCGGAGCGCGGCGCTAGGAATGCC
CTCGGCGGCCACCAGGAGGCACCGGAGAGAGAAAGGCGGTCCGAGGAGCCTCCCATCTCC
CTGGATCTCACCTTCCACCTCCTCCGGGAAGTCTTGGAAATGGCCAGGGCCGAGCAGTTA
GCACAGCAAGCTCACAGCAACAGGAAACTCATGGAGATTATTGGGAAATAA

# Macromolecular_Interacting_Partner_42_GenBank_ID_Gene:
V00571

# Macromolecular_Interacting_Partner_42_Chromosome_Location:
Chromosome:8

# Macromolecular_Interacting_Partner_42_Locus:
8q13

# Macromolecular_Interacting_Partner_42_SNPs:
rs6159; rs3176921; rs6472257; rs6999780; rs6982394; rs6158; rs6156; rs7459924; rs6157; rs35365635; rs41545719; rs11309939; rs3832590; rs10086258; rs10090644; rs10090752; rs10093091; rs10098823; rs10105164; rs1054108; rs10957368; rs11986876; rs11993711; rs11997294; rs11997416; rs11997816; rs12543727; rs12721507; rs12721508; rs12721509; rs12721510; rs12721511; rs16932615; rs1870392; rs4344056; rs4501563; rs5030875; rs5030877; rs6472258; rs6472259; rs6984398; rs6990486; rs6996265; rs6999100; rs7010547; rs7013524; rs7350113; rs7816410; rs7832858; rs7835214; rs7839698

# Macromolecular_Interacting_Partner_42_General_References:
6605851; 2783917; 3262120; 8386360

# Macromolecular_Interacting_Partner_42_References:
16720310; 16956982

# Macromolecular_Interacting_Partner_43_ID:
8059

# Macromolecular_Interacting_Partner_43_Name:
cAMP-dependent protein kinase type I-alpha regulatory subunit

# Macromolecular_Interacting_Partner_43_Synonyms:
Tissue- specific extinguisher 1; TSE1

# Macromolecular_Interacting_Partner_43_Gene_Name:
PRKAR1A

# Macromolecular_Interacting_Partner_43_Protein_Sequence:
>cAMPdependent protein kinase type Ialpha regulatory subunit
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKE
EAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPK
DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTL
RKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSA
AVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLG
PCSDILKRNIQQYNSFVSLSV

# Macromolecular_Interacting_Partner_43_Number_of_Residues:
381

# Macromolecular_Interacting_Partner_43_Molecular_Weight:
42982

# Macromolecular_Interacting_Partner_43_Theoretical_pI:
5.00

# Macromolecular_Interacting_Partner_43_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  kinase regulator activity
Function:  protein kinase regulator activity
Function:  cAMP-dependent protein kinase regulator activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  protein complex
Component:  unlocalized protein complex
Component:  cAMP-dependent protein kinase complex

# Macromolecular_Interacting_Partner_43_General_Function:
Signal transduction mechanisms 

# Macromolecular_Interacting_Partner_43_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_43_Pathway:
Not Available

# Macromolecular_Interacting_Partner_43_Reaction:
Not Available

# Macromolecular_Interacting_Partner_43_Pfam_Domain_Function:
PF00027:cNMP_binding;
PF02197:RIIa

# Macromolecular_Interacting_Partner_43_Signals:
None

# Macromolecular_Interacting_Partner_43_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_43_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_43_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_43_GenBank_ID_Protein:
179922

# Macromolecular_Interacting_Partner_43_SwissProt_ID:
KAP0_HUMAN (P10644)

# Macromolecular_Interacting_Partner_43_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_43_Genecard_id:
PRKAR1A

# Macromolecular_Interacting_Partner_43_Geneatlas_id:
PRKAR1A

# Macromolecular_Interacting_Partner_43_hgnc_id:
HGNC:9388

# Macromolecular_Interacting_Partner_43_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_43_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_43_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_43_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_43_Gene_Sequence:
>1146 bp
ATGGAGTCTGGCAGTACCGCCGCCAGTGAGGAGGCACGCAGCCTTCGAGAATGTGAGCTC
TACGTCCAGAAGCATAACATTCAAGCGCTGCTCAAAGATTCTATTGTGCAGTTGTGCACT
GCTCGACCTGAGAGACCCATGGCATTCCTCAGGGAATACTTTGAGAGGTTGGAGAAGGAG
GAGGCAAAACAGATTCAGAATCTGCAGAAAGCAGGCACTCGTACAGACTCAAGGGAGGAT
GAGATTTCTCCTCCTCCACCCAACCCAGTGGTTAAAGGTAGGAGGCGACGAGGTGCTATC
AGCGCTGAGGTCTACACGGAGGAAGATGCGGCATCCTATGTTAGAAAGGTTATACCAAAA
GATTACAAGACAATGGCCGCTTTAGCCAAAGCCATTGAAAAGAATGTGCTGTTTTCACAT
CTTGATGATAATGAGAGAAGTGATATTTTTGATGCCATGTTTTCGGTCTCCTTTATCGCA
GGAGAGACTGTGATTCAGCAAGGTGATGAAGGGGATAACTTCTATGTGATTGATCAAGGA
GAGACGGATGTCTATGTTAACAATGAATGGGCAACCAGTGTTGGGGAAGGAGGGAGCTTT
GGAGAACTTGCTTTGATTTATGGAACACCGAGAGCAGCCACTGTCAAAGCAAAGACAAAT
GTGAAATTGTGGGGCATCGACCGAGACAGCTATAGAAGAATCCTCATGGGAAGCACACTG
AGAAAGCGGAAGATGTATGAGGAATTCCTTAGTAAAGTCTCTATTTTAGAGTCTCTGGAC
AAGTGGGAACGTCTTACGGTAGCTGATGCATTGGAACCAGTGCAGTTTGAAGATGGGCAG
AAGATTGTGGTGCAGGGAGAACCAGGGGATGAGTTCTTCATTATTTTAGAGGGGTCAGCT
GCTGTGCTACAACGTCGGTCAGAAAATGAAGAGTTTGTTGAAGTGGGAAGATTGGGGCCT
TCTGATTATTTTGGTGAAATTGCACTACTGATGAATCGTCCTCGTGCTGCCACAGTTGTT
GCTCGTGGCCCCTTGAAGTGCGTTAAGCTGGACCGACCTAGATTTGAACGTGTTCTTGGC
CCATGCTCAGACATCCTCAAACGAAACATCCAGCAGTACAACAGTTTTGTGTCACTGTCT
GTCTGA

# Macromolecular_Interacting_Partner_43_GenBank_ID_Gene:
M18468

# Macromolecular_Interacting_Partner_43_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_43_Locus:
17q23-q24

# Macromolecular_Interacting_Partner_43_SNPs:
rs3730349; rs8905; rs9925; rs9913595; rs6958; rs8080306; rs8082254; rs7977; rs4265886; rs1064757; rs8080739; rs2952275; rs2302230; rs4281788; rs2907387; rs2952272; rs11651687; rs2952274; rs8076465; rs10468445; rs11867767; rs16972996; rs3785905; rs8068323; rs2302233; rs11868368; rs11868251; rs2952273; rs7217296; rs2302232; rs7219227; rs16973011; rs8072941; rs8072791; rs2302231; rs2907374; rs8076819; rs17550507; rs3785906; rs1803241; rs3730371; rs4561532; rs1064756; rs34358618; rs12939412; rs7213438; rs28730842; rs8079916; rs34656814; rs11540571; rs11359559; rs8072598; rs28675972; rs12941038; rs28524039; rs10468444; rs3730372; rs35654040; rs3730369; rs28801441; rs34658103; rs35723852; rs4968899; rs7221724; rs3217054; rs3841514; rs11362814; rs3730375; rs11653616; rs10625677; rs10602368; rs2907376; rs35205650; rs35387344; rs11379909; rs28521534; rs9889466; rs9897854; rs11315953; rs35776975; rs2907372; rs34460519; rs10432004; rs28730841; rs5821659; rs12940651; rs10719461; rs35144524; rs12453086; rs12952571; rs16972990; rs16973034; rs16973042; rs2015212; rs2286554; rs2286555; rs2286556; rs2286557; rs2286558; rs2286559; rs2286560; rs2286561; rs2302234; rs2302235; rs2907373; rs2952270; rs2952271; rs34017561; rs4968898; rs8066131; rs9892782; rs9897875; rs9911549; rs9912712; rs9915512; rs9915974

# Macromolecular_Interacting_Partner_43_General_References:
3426618; 2310396; 1889088; 8977401; 12665801

# Macromolecular_Interacting_Partner_43_References:
16767104

# Macromolecular_Interacting_Partner_44_ID:
7748

# Macromolecular_Interacting_Partner_44_Name:
Glial fibrillary acidic protein, astrocyte

# Macromolecular_Interacting_Partner_44_Synonyms:
GFAP

# Macromolecular_Interacting_Partner_44_Gene_Name:
GFAP

# Macromolecular_Interacting_Partner_44_Protein_Sequence:
>Glial fibrillary acidic protein, astrocyte
MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNA
GFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAEL
RELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEAT
LARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRT
QYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLR
GTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALD
IEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEV
IKESKQEHKDVM

# Macromolecular_Interacting_Partner_44_Number_of_Residues:
432

# Macromolecular_Interacting_Partner_44_Molecular_Weight:
49881

# Macromolecular_Interacting_Partner_44_Theoretical_pI:
5.21

# Macromolecular_Interacting_Partner_44_GO_Classification:
>>>
Function:  structural molecule activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  organelle
Component:  non-membrane-bound organelle
Component:  intracellular non-membrane-bound organelle
Component:  cytoskeleton
Component:  intermediate filament cytoskeleton
Component:  intermediate filament

# Macromolecular_Interacting_Partner_44_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_44_Specific_Function:
GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells

# Macromolecular_Interacting_Partner_44_Pathway:
Not Available

# Macromolecular_Interacting_Partner_44_Reaction:
Not Available

# Macromolecular_Interacting_Partner_44_Pfam_Domain_Function:
PF00038:Filament;
PF04732:Filament_head

# Macromolecular_Interacting_Partner_44_Signals:
None

# Macromolecular_Interacting_Partner_44_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_44_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_44_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_44_GenBank_ID_Protein:
183075

# Macromolecular_Interacting_Partner_44_SwissProt_ID:
GFAP_HUMAN (P14136)

# Macromolecular_Interacting_Partner_44_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_44_Genecard_id:
GFAP

# Macromolecular_Interacting_Partner_44_Geneatlas_id:
GFAP

# Macromolecular_Interacting_Partner_44_hgnc_id:
HGNC:4235

# Macromolecular_Interacting_Partner_44_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_44_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_44_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_44_Subcellular_Location:
Cytoplasm. Note=Associated with intermediate filaments

# Macromolecular_Interacting_Partner_44_Gene_Sequence:
>1299 bp
ATGGAGAGGAGACGCATCACCTCCGCTGCTCGCCGCTCCTACGTCTCCTCAGGGGAGATG
ATGGTGGGGGGCCTGGCTCCTGGCCGCCGTCTGGGTCCTGGCACCCGCCTCTCCCTGGCT
CGAATGCCCCCTCCACTCCCGACCCGGGTGGATTTCTCCCTGGCTGGGGCACTCAATGCT
GGCTTCAAGGAGACCCGGGCCAGTGAGCGGGCAGAGATGATGGAGCTCAATGACCGCTTT
GCCAGCTACATCGAGAAGGTTCGCTTCCTGGAACAGCAAAACAAGGCGCTGGCTGCTGAG
CTGAACCAGCTGCGGGCCAAGGAGCCCACCAAGCTGGCAGACGTCTACCAGGCTGAGCTG
CGAGAGCTGCGGCTGCGGCTCGATCAACTCACCGCCAACAGCGCCCGGCTGGAGGTTGAG
AGGGACAATCTGGCACAGGACCTGGCCACTGTGAGGCAGAAGCTCCAGGATGAAACCAAC
CTGAGGCTGGAAGCCGAGAACAACCTGGCTGCCTATAGACAGGAAGCAGATGAAGCCACC
CTGGCCCGTCTGGATCTGGAGAGGAAGATTGAGTCGCTGGAGGAGGAGATCCGGTTCTTG
AGGAAGATCCACGAGGAGGAGGTTCGGGAACTCCAGGAGCAGCTGGCCCGACAGCAGGTC
CATGTGGAGCTTGACGTGGCCAAGCCAGACCTCACCGCAGCCCTGAAAGAGATCCGCACG
CAGTATGAGGCAATGGCGTCCAGCAACATGCATGAAGCCGAAGAGTGGTACCGCTCCAAG
TTTGCAGACCTGACAGACGCTGCTGCCCGCAACGCGGAGCTGCTCCGCCAGGCCAAGCAC
GAAGCCAACGACTACCGGCGCCAGTTGCAGTCCTTGACCTGCGACCTGGAGTCTCTGCGC
GGCACGAACGAGTCCCTGGAGAGGCAGATGCGCGAGCAGGAGGAGCGGCACGTGCGGGAG
GCGGCCAGTTATCAGGAGGCGCTGGCGCGGCTGGAGGAAGAGGGGCAGAGCCTCAAGGAC
GAGATGGCCCGCCACTTGCAGGAGTACCAGGACCTGCTCAATGTCAAGCTGGCCCTGGAC
ATCGAGATCGCCACCTACAGGAAGCTGCTAGAGGGCGAGGAGAACCGGATCACCATTCCC
GTGCAGACCTTCTCCAACCTGCAGATTCGAGAAACCAGCCTGGACACCAAGTCTGTGTCA
GAAGGCCACCTCAAGAGGAACATCGTGGTGAAGACCGTGGAGATGCGGGATGGAGAGGTC
ATTAAGGAGTCCAAGCAGGAGCACAAGGATGTGATGTGA

# Macromolecular_Interacting_Partner_44_GenBank_ID_Gene:
J04569

# Macromolecular_Interacting_Partner_44_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_44_Locus:
17q21

# Macromolecular_Interacting_Partner_44_SNPs:
rs1126642; rs2289681; rs2229011; rs2229012; rs1042329; rs3744470; rs17027; rs8067254; rs1042408; rs7049; rs9916491; rs2289679; rs11651396; rs3744468; rs1443462; rs12603981; rs3785891; rs17629022; rs12941832; rs9901503; rs2289671; rs9915329; rs1443461; rs8067029; rs3744469; rs3744473; rs3760379; rs12222; rs2070935; rs3826425; rs12937256; rs28932769; rs11558960; rs1803645; rs1042465; rs34579312; rs1803641; rs35560537; rs1803643; rs1803642; rs1803644; rs11558961; rs3211430; rs28688440; rs9908084; rs34137050; rs12601146; rs8079065; rs3816276; rs35656748; rs35909232; rs4514714; rs34322994; rs3816277; rs8065473; rs34637106; rs8079849; rs34001162; rs35632421; rs3760378; rs12952204; rs35098586; rs35207454; rs8079392; rs28485918; rs10451268; rs10451269; rs1059248; rs1059249; rs11079382; rs11650246; rs12150314; rs12150466; rs12150556; rs12451394; rs12453275; rs12947309; rs16939676; rs16939730; rs17546654; rs17628574; rs2017257; rs2277616; rs2277617; rs3809756; rs7222312; rs8068761; rs8079308; rs8079610; rs8080642; rs9904512; rs9908594; rs9909048

# Macromolecular_Interacting_Partner_44_General_References:
2740350; 2163003; 1636374; 9693047; 2349237; 2780570; 12058025; 12837269; 11138011; 11567214; 11595337; 12034796; 12975300; 12944715

# Macromolecular_Interacting_Partner_44_References:
16806201; 16998865; 17078756

# Macromolecular_Interacting_Partner_45_ID:
8352

# Macromolecular_Interacting_Partner_45_Name:
Parvalbumin alpha

# Macromolecular_Interacting_Partner_45_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_45_Gene_Name:
PVALB

# Macromolecular_Interacting_Partner_45_Protein_Sequence:
>Parvalbumin alpha
MSMTDLLNAEDIKKAVGAFSATDSFDHKKFFQMVGLKKKSADDVKKVFHMLDKDKSGFIE
EDELGFILKGFSPDARDLSAKETKMLMAAGDKDGDGKIGVDEFSTLVAES

# Macromolecular_Interacting_Partner_45_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_45_Molecular_Weight:
12059

# Macromolecular_Interacting_Partner_45_Theoretical_pI:
4.78

# Macromolecular_Interacting_Partner_45_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_45_General_Function:
Not Available

# Macromolecular_Interacting_Partner_45_Specific_Function:
In muscle, the calcium-binding protein parvalbumin is thought to be involved in muscle relaxation

# Macromolecular_Interacting_Partner_45_Pathway:
Not Available

# Macromolecular_Interacting_Partner_45_Reaction:
Not Available

# Macromolecular_Interacting_Partner_45_Pfam_Domain_Function:
PF00036:efhand

# Macromolecular_Interacting_Partner_45_Signals:
None

# Macromolecular_Interacting_Partner_45_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_45_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_45_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_45_GenBank_ID_Protein:
35808

# Macromolecular_Interacting_Partner_45_SwissProt_ID:
PRVA_HUMAN (P20472)

# Macromolecular_Interacting_Partner_45_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_45_Genecard_id:
PVALB

# Macromolecular_Interacting_Partner_45_Geneatlas_id:
PVALB

# Macromolecular_Interacting_Partner_45_hgnc_id:
HGNC:9704

# Macromolecular_Interacting_Partner_45_PDB_ID:
1RK9

# Macromolecular_Interacting_Partner_45_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_45_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_45_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_45_Gene_Sequence:
>327 bp
ATGTCGATGACAGACTTGCTGAACGCTGAGGACATCAAGAAGGCGGTGGGAGCCTTTAGC
GCTACCGACTCCTTCGACCACAAAAAGTTCTTCCAAATGGTCGGCCTGAAGAAAAAGAGT
GCGGATGATGTGAAGAAGGTGTTTCACATGCTGGACAAGGACAAAAGTGGCTTCATCGAG
GAGGATGAGCTGGGATTCATCCTAAAAGGCTTCTCCCCAGATGCCAGAGACCTGTCTGCT
AAAGAAACCAAGATGCTGATGGCTGCTGGAGACAAAGATGGGGACGGCAAAATTGACGAA
TTCTCCACTCTGGTGGCTGAAAGCTAA

# Macromolecular_Interacting_Partner_45_GenBank_ID_Gene:
X63578

# Macromolecular_Interacting_Partner_45_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_45_Locus:
22q12-q13.1|22q13.1

# Macromolecular_Interacting_Partner_45_SNPs:
rs3484; rs2284026; rs2284025; rs12483924; rs5750313; rs762917; rs2001063; rs736720; rs12171125; rs4820252; rs1894479; rs2022068; rs6519035; rs739031; rs9610587; rs5750309; rs4820250; rs6519034; rs9622488; rs2284022; rs5750310; rs4821536; rs13057042; rs2071709; rs4821535; rs7511216; rs4820249; rs2067069; rs4820255; rs4821532; rs4821531; rs7288290; rs2269512; rs11913972; rs736721; rs2269511; rs2284021; rs4821534; rs762920; rs4820253; rs2284023; rs6000426; rs11913267; rs2284024; rs4820254; rs4820251; rs2284019; rs5750311; rs2067068; rs13057439; rs10775741; rs13056258; rs2413421; rs2001064; rs4239881; rs4820248; rs2413423; rs2267362; rs2227064; rs2413422; rs5756345; rs5756349; rs5756347; rs5756346; rs4820247; rs17810287; rs2213429; rs4821529; rs4820246; rs4821530; rs4821528; rs1131432; rs35095499; rs34926114; rs9607383; rs34561646; rs34159767; rs9622489; rs11703317; rs7286330; rs6000427; rs4821533; rs12053777; rs7287999; rs5004490; rs4084292; rs7290425; rs5845300; rs12159841; rs35988819; rs13055296; rs7287559; rs13054448; rs5750312; rs11913511; rs13055625; rs10599854; rs28372402; rs12168594; rs28473514; rs11705163; rs4820256; rs34281373; rs5756351; rs35724962; rs12159680; rs10605026; rs35805671; rs5845302; rs12483785; rs34262500; rs7290723; rs11370531; rs4414767; rs36215449; rs9610586; rs4630865; rs2284020; rs5756350; rs7410360; rs5756353; rs12330085; rs9610585; rs5845299; rs5995346; rs5750314; rs9610588; rs5756348; rs6000428; rs2227065; rs12159863; rs17810645; rs28582101; rs4616572; rs5756354; rs5756357; rs5756363; rs6000425; rs6650880; rs9607382; rs9610583; rs9619636

# Macromolecular_Interacting_Partner_45_General_References:
2614829; 8354278; 10591208; 10036163

# Macromolecular_Interacting_Partner_45_References:
16650608; 16781818

# Macromolecular_Interacting_Partner_46_ID:
7781

# Macromolecular_Interacting_Partner_46_Name:
Cysteine and glycine-rich protein 1

# Macromolecular_Interacting_Partner_46_Synonyms:
Cysteine-rich protein 1; CRP1; CRP

# Macromolecular_Interacting_Partner_46_Gene_Name:
CSRP1

# Macromolecular_Interacting_Partner_46_Protein_Sequence:
>Cysteine and glycinerich protein 1
MPNWGGGKKCGVCQKTVYFAEEVQCEGNSFHKSCFLCMVCKKNLDSTTVAVHGEEIYCKS
CYGKKYGPKGYGYGQGAGTLSTDKGESLGIKHEEAPGHRPTTNPNASKFAQKIGGSERCP
RCSQAVYAAEKVIGAGKSWHKACFRCAKCGKGLESTTLADKDGEIYCKGCYAKNFGPKGF
GFGQGAGALVHSE

# Macromolecular_Interacting_Partner_46_Number_of_Residues:
193

# Macromolecular_Interacting_Partner_46_Molecular_Weight:
20567

# Macromolecular_Interacting_Partner_46_Theoretical_pI:
8.68

# Macromolecular_Interacting_Partner_46_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_46_General_Function:
Not Available

# Macromolecular_Interacting_Partner_46_Specific_Function:
Could play a role in neuronal development

# Macromolecular_Interacting_Partner_46_Pathway:
Not Available

# Macromolecular_Interacting_Partner_46_Reaction:
Not Available

# Macromolecular_Interacting_Partner_46_Pfam_Domain_Function:
PF00412:LIM

# Macromolecular_Interacting_Partner_46_Signals:
None

# Macromolecular_Interacting_Partner_46_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_46_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_46_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_46_GenBank_ID_Protein:
181071

# Macromolecular_Interacting_Partner_46_SwissProt_ID:
CSRP1_HUMAN (P21291)

# Macromolecular_Interacting_Partner_46_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_46_Genecard_id:
CSRP1

# Macromolecular_Interacting_Partner_46_Geneatlas_id:
CSRP1

# Macromolecular_Interacting_Partner_46_hgnc_id:
HGNC:2469

# Macromolecular_Interacting_Partner_46_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_46_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_46_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_46_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_46_Gene_Sequence:
>582 bp
ATGCCGAACTGGGGAGGAGGCAAGAAATGTGGGGTGTGTCAGAAGACGGTTTACTTTGCC
GAAGAGGTTCAGTGCGAAGGCAACAGCTTCCATAAATCCTGCTTCCTGTGCATGGTCTGC
AAGAAGAATCTGGACAGTACCACTGTGGCCGTGCATGGTGAGGAGATTTACTGCAAGTCC
TGCTACGGCAAGAAGTATGGGCCCAAAGGCTATGGCTACGGGCAGGGCGCAGGCACCCTC
AGCACTGACAAGGGGGAGTCGCTGGGTATCAAGCACGAGGAAGCCCCTGGCCACAGGCCC
ACCACCAACCCCAATGCATCCAAATTTGCCCAGAAGATTGGTGGCTCCGAGCGCTGCCCC
CGATGCAGCCAGGCAGTCTATGCTGCGGAGAAGGTGATTGGTGCTGGGAAGTCCTGGCAT
AAGGCCTGCTTTCGATGTGCCAAGTGTGGCAAAGGCCTTGAGTCAACCACCCTGGCAGAC
AAGGATGGCGAGATTTACTGCAAAGGATGTTATGCTAAAAACTTCGGGCCCAAGGGCTTT
GGTTTTGGGCAAGGAGCTGGGGCCTTGGTCCACTCTGAGTGA

# Macromolecular_Interacting_Partner_46_GenBank_ID_Gene:
M33146

# Macromolecular_Interacting_Partner_46_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_46_Locus:
1q32

# Macromolecular_Interacting_Partner_46_SNPs:
rs3738283; rs504667; rs485060; rs10800784; rs673640; rs475416; rs685023; rs10800785; rs4915529; rs6427911; rs2038972; rs1262292; rs603836; rs592865; rs568796; rs4024239; rs576697; rs3767532; rs610282; rs688219; rs9628676; rs6693013; rs9628675; rs11811028; rs1054064; rs3753989; rs10920213; rs3753986; rs2210733; rs2210732; rs17428663; rs9628682; rs17428775; rs623791; rs17428726; rs683467; rs641581; rs682600; rs515384; rs680198; rs7527761; rs668565; rs3738285; rs10753903; rs3767542; rs4915528; rs12403361; rs7538112; rs682137; rs688621; rs571475; rs554616; rs927901; rs7540543; rs544677; rs927900; rs2070941; rs16848754; rs16848786; rs641103; rs2070942; rs12729389; rs3767538; rs495886; rs3767541; rs12134525; rs16848783; rs645390; rs641551; rs675508; rs11585456; rs913175; rs7518677; rs12077954; rs682542; rs683027; rs16848752; rs631593; rs13374558; rs752756; rs7537513; rs2296693; rs12401636; rs499350; rs1932020; rs10800783; rs12402783; rs494838; rs553580; rs527136; rs3753979; rs12404350; rs586507; rs945202; rs3753984; rs3753981; rs1998920; rs3753982; rs3820429; rs12128588; rs11550382; rs11550380; rs1803328; rs34504522; rs11550379; rs35393770; rs3753988; rs1053635; rs3753987; rs11579310; rs3767526; rs1256925; rs6693682; rs1053729; rs1054050; rs34362987; rs11808347; rs34354700; rs10920214; rs12076215; rs1054160; rs1054180; rs5780074; rs2038971; rs3738282; rs3834073; rs10676830; rs1054077; rs35735390; rs1053677; rs12087552; rs35518464; rs34420666; rs3767529; rs10590958; rs662436; rs35887268; rs10687143; rs3835599; rs1803327; rs12031021; rs1803326; rs34365999; rs34671394; rs2782579; rs3738284; rs2004565; rs12078049; rs573193; rs35058370; rs35672250; rs35324992; rs34482449; rs41304273; rs12035810; rs12089715; rs572267; rs34038448; rs13375871; rs34682548; rs13374492; rs3767540; rs12070807; rs5780073; rs34238424; rs34323772; rs1932021; rs1932022; rs4558002; rs11582347; rs35387570; rs553617; rs1762234; rs4600073; rs1033995; rs10800786; rs10920212; rs11582922; rs12021779; rs12037225; rs12040721; rs12076873; rs12117517; rs12134619; rs12135020; rs12142498; rs12562650; rs12758212; rs16848852; rs17469014; rs3767524; rs3767525; rs497843; rs544594; rs593375; rs606976; rs620784; rs6657465

# Macromolecular_Interacting_Partner_46_General_References:
2115670; 1374386

# Macromolecular_Interacting_Partner_46_References:
16934214; 16946269; 17073754; 17087497

# Macromolecular_Interacting_Partner_47_ID:
8195

# Macromolecular_Interacting_Partner_47_Name:
Follicle-stimulating hormone receptor precursor

# Macromolecular_Interacting_Partner_47_Synonyms:
FSH-R; Follitropin receptor

# Macromolecular_Interacting_Partner_47_Gene_Name:
FSHR

# Macromolecular_Interacting_Partner_47_Protein_Sequence:
>Folliclestimulating hormone receptor precursor
MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRV
IQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLP
NLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKN
GIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLEN
LKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQE
VDYMTQTRGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIM
GYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIAS
VDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCK
VQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVL
AFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVP
LITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSS
TVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN

# Macromolecular_Interacting_Partner_47_Number_of_Residues:
695

# Macromolecular_Interacting_Partner_47_Molecular_Weight:
78296

# Macromolecular_Interacting_Partner_47_Theoretical_pI:
7.19

# Macromolecular_Interacting_Partner_47_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  protein-hormone receptor activity
Function:  follicle stimulating hormone receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_47_General_Function:
Not Available

# Macromolecular_Interacting_Partner_47_Specific_Function:
Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase

# Macromolecular_Interacting_Partner_47_Pathway:
Not Available

# Macromolecular_Interacting_Partner_47_Reaction:
Not Available

# Macromolecular_Interacting_Partner_47_Pfam_Domain_Function:
PF00001:7tm_1;
PF00560:LRR_1;
PF01462:LRRNT

# Macromolecular_Interacting_Partner_47_Signals:
1-17

# Macromolecular_Interacting_Partner_47_Transmembrane_Regions:
367-387
399-421
444-465
486-508
529-550
574-597
609-630

# Macromolecular_Interacting_Partner_47_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_47_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_47_GenBank_ID_Protein:
182771

# Macromolecular_Interacting_Partner_47_SwissProt_ID:
FSHR_HUMAN (P23945)

# Macromolecular_Interacting_Partner_47_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_47_Genecard_id:
FSHR

# Macromolecular_Interacting_Partner_47_Geneatlas_id:
FSHR

# Macromolecular_Interacting_Partner_47_hgnc_id:
HGNC:3969

# Macromolecular_Interacting_Partner_47_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_47_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_47_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_47_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_47_Gene_Sequence:
>2088 bp
ATGGCCCTGCTCCTGGTCTCTTTGCTGGCATTCCTGAGCTTGGGCTCAGGATGTCATCAT
CGGATCTGTCACTGCTCTAACAGGGTTTTTCTCTGCCAAGAGAGCAAGGTGACAGAGATT
CCTTCTGACCTCCCGAGGAATGCCATTGAACTGAGGTTTGTCCTCACCAAGCTTCGAGTC
ATCCAAAAAGGTGCATTTTCAGGATTTGGGGACCTGGAGAAAATAGAGATCTCTCAGAAT
GATGTCTTGGAGGTGATAGAGGCAGATGTGTTCTCCAACCTTCCCAAATTACATGAAATT
AGAATTGAAAAGGCCAACAACCTGCTCTACATCACCCCTGAGGCCTTCCAGAACCTTCCC
AACCTTCAATATCTGTTAATATCCAACACAGGTATTAAGCACCTTCCAGATGTTCACAAG
ATTCATTCTCTCCAAAAGGTTTTACTTGACATTCAAGATAACATAAACATCCACACAATT
GAAAGAAATTCTTTCGTGGGGCTGAGCTTTGAAAGTGTGATTCTATGGCTGAATAAGAAT
GGGATTCAAGAAATACACAACTGTGCATTCAATGGAACCCAACTAGATGCAGTGAATCTA
AGCGATAATAATAATTTAGAAGAATTGCCTAATGATGTTTTCCACGGAGCCTCTGGACCA
GTCATTCTAGATATTTCAAGAACAAGGATCCATTCCCTGCCTAGCTATGGCTTAGAAAAT
CTTAAGAAGCTGAGGGCCAGGTCGACTTACAACTTAAAAAAGCTGCCTACTCTGGAAAAG
CTTGTCGCCCTCATGGAAGCCAGCCTCACCTATCCCAGCCATTGCTGTGCCTTTGCAAAC
TGGAGACGGCAAATCTCTGAGCTTCATCCAATTTGCAACAAATCTATTTTAAGGCAAGAA
GTTGATTATATGACTCAGGCTAGGGGTCAGAGATCCTCTCTGGCAGAAGACAATGAGTCC
AGCTACAGCAGAGGATTTGACATGACGTACACTGAGTTTGACTATGACTTATGCAATGAA
GTGGTTGACGTGACCTGCTCCCCTAAGCCAGATGCATTCAACCCATGTGAAGATATCATG
GGGTACAACATCCTCAGAGTCCTGATATGGTTTATCAGCATCCTGGCCATCACTGGGAAC
ATCATAGTGCTAGTGATCCTAACTACCAGCCAATATAAACTCACAGTCCCCAGGTTCCTT
ATGTGCAACCTGGCCTTTGCTGATCTCTGCATTGGAATCTACCTGCTGCTCATTGCATCA
GTTGATATCCATACCAAGAGCCAATATCACAACTATGCCATTGACTGGCAAACTGGGGCA
GGCTGTGATGCTGCTGGCTTTTTCACTGTCTTTGCCAGTGAGCTGTCAGTCTACACTCTG
ACAGCTATCACCTTGGAAAGATGGCATACCATCACGCATGCCATGCAGCTGGACTGCAAG
GTGCAGCTCCGCCATGCTGCCAGTGTCATGGTGATGGGCTGGATTTTTGCTTTTGCAGCT
GCCCTCTTTCCCATCTTTGGCATCAGCAGCTACATGAAGGTGAGCATCTGCCTGCCCATG
GATATTGACAGCCCTTTGTCACAGCTGTATGTCATGTCCCTCCTTGTGCTCAATGTCCTG
GCCTTTGTGGTCATCTGTGGCTGCTATATCCACATCTACCTCACAGTGCGGAACCCCAAC
ATCGTGTCCTCCTCTAGTGACACCAGGATCGCCAAGCGCATGGCCATGCTCATCTTCACT
GACTTCCTCTGCATGGCACCCATTTCTTTCTTTGCCATTTCTGCCTCCCTCAAGGTGCCC
CTCATCACTGTGTCCAAAGCAAAGATTCTGCTGGTTCTGTTTCACCCCATCAACTCCTGT
GCCAACCCCTTCCTCTATGCCATCTTTACCAAAAACTTTCGCAGAGATTTCTTCATTCTG
CTGAGCAAGTGTGGCTGCTATGAAATGCAAGCCCAAATTTATAGGACAGAAACTTCATCC
ACTGTCCACAACACCCATCCAAGGAATGGCCACTGCTCTTCAGCTCCCAGAGTCACCAGT
GGTTCCACTTACATACTTGTCCCTCTAAGTCATTTAGCCCAAAACTAA

# Macromolecular_Interacting_Partner_47_GenBank_ID_Gene:
M65085

# Macromolecular_Interacting_Partner_47_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_47_Locus:
2p21-p16

# Macromolecular_Interacting_Partner_47_SNPs:
rs6166; rs6165; rs12620825; rs1394205; rs974896; rs1910564; rs1504176; rs1504182; rs2072484; rs1504188; rs2072489; rs1014274; rs924819; rs1504190; rs1290100; rs1922464; rs1504189; rs1922462; rs1504184; rs976230; rs974897; rs1922470; rs1922463; rs1882560; rs2300444; rs2349715; rs1126075; rs1910566; rs1922466; rs7590213; rs6545090; rs1504166; rs4971622; rs2268363; rs4952933; rs11125190; rs12477795; rs12713030; rs6724851; rs2349711; rs6741370; rs4510264; rs2300437; rs10865238; rs10191244; rs13415618; rs7568381; rs2072487; rs2058595; rs6545094; rs6705106; rs4953652; rs1504186; rs9808508; rs1504169; rs10176392; rs1504191; rs2072486; rs1504167; rs1558607; rs11898430; rs7594937; rs6708637; rs13004879; rs2349412; rs11125189; rs1857706; rs971831; rs12473181; rs4971884; rs6545096; rs12713029; rs13024843; rs10190904; rs4355155; rs12713034; rs1922477; rs2268359; rs6545095; rs3892124; rs7606570; rs4971623; rs7591844; rs3913665; rs2349712; rs1504183; rs13414533; rs6732220; rs10490116; rs905668; rs1504180; rs2072485; rs1011576; rs7560175; rs1553476; rs12713035; rs6746533; rs1007541; rs13026647; rs7607503; rs10195036; rs953547; rs11898451; rs1558609; rs1394207; rs12465332; rs4331540; rs10183322; rs2300439; rs6708725; rs1504174; rs958974; rs6545092; rs2349714; rs2300443; rs12713031; rs11889194; rs4953650; rs2349413; rs1011578; rs976229; rs11125213; rs1504175; rs1011577; rs12713036; rs917944; rs3850344; rs2349710; rs1504185; rs7563620; rs1604821; rs11125198; rs1277458; rs4953655; rs2268360; rs1277459; rs12614817; rs9309159; rs12713027; rs2072488; rs1157876; rs2300440; rs3788986; rs4971665; rs960038; rs1922469; rs2349415; rs917943; rs12996623; rs12994034; rs10495967; rs12997223; rs13387260; rs12713033; rs2091787; rs3788983; rs13005029; rs2202325; rs4971637; rs12622916; rs13001629; rs1922471; rs759287; rs12465687; rs12991599; rs13022022; rs11898099; rs17038026; rs1504170; rs12713037; rs1394202; rs3913666; rs1504173; rs12105877; rs4971642; rs2268358; rs6736924; rs2268361; rs905667; rs4246578; rs17038320; rs10199061; rs1277460; rs10490117; rs17038105; rs11894971; rs7571781; rs12620805; rs10186089; rs13017992; rs7577214; rs7595525; rs11689334; rs17038373; rs11903014; rs11125191; rs2300438; rs2349716; rs3913668; rs13032037; rs917942; rs1317218; rs887944; rs17772297; rs12614875; rs1504171; rs13389334; rs11125192; rs13009434; rs1159894; rs1504177; rs2160148; rs10185522; rs917945; rs2055571; rs6722409; rs12613782; rs17038059; rs17038116; rs11692782; rs12623845; rs12471547; rs7424375; rs11125214; rs10490118; rs6707239; rs1553475; rs989359; rs13010134; rs7426210; rs11681320; rs1922472; rs13002557; rs10490115; rs17038288; rs11694529; rs13396575; rs11896309; rs6545091; rs10211458; rs985909; rs7596503; rs11889050; rs2072483; rs17038054; rs11891370; rs7604476; rs12713028; rs9808506; rs1558608; rs1910567; rs10495965; rs3788981; rs7568202; rs1316521; rs17038087; rs974894; rs10495966; rs10199118; rs12473815; rs6735454; rs6545089; rs2284674; rs17038285; rs13031735; rs8179692; rs1394209; rs988103; rs1504178; rs9789669; rs4494802; rs11902601; rs9789577; rs11891561; rs17038242; rs11676909; rs1922468; rs10495962; rs2091786; rs917941; rs12052281; rs11689714; rs4971882; rs12473870; rs9807991; rs10195241; rs11125197; rs11125215; rs1922473; rs17038379; rs7572787; rs3788985; rs17038027; rs17038094; rs17038361; rs12479167; rs2349414; rs7597101; rs10495964; rs6760923; rs974895; rs12473794; rs6753729; rs3788982; rs12465603; rs2134811; rs2349709; rs17038141; rs17038275; rs7562108; rs12622919; rs10495968; rs2882157; rs11125206; rs2284673; rs13032266; rs1504181; rs13009588; rs9941637; rs13002977; rs1922474; rs11125202; rs7423208; rs10195635; rs1007540; rs11125193; rs12622922; rs11887282; rs11693287; rs6716567; rs11884101; rs2089121; rs6716923; rs17038381; rs4971643; rs17038315; rs13424726; rs17038075; rs2055572; rs4953651; rs11125194; rs11686783; rs11675903; rs3913667; rs11902815; rs7568182; rs17823341; rs13020979; rs17038224; rs17038364; rs11897710; rs11678671; rs13001440; rs6749398; rs1604822; rs11125199; rs17038159; rs11898204; rs11125207; rs9309157; rs1882557; rs11125210; rs12997920; rs13008324; rs12620153; rs1910565; rs17038117; rs2055573; rs12988126; rs1808310; rs7589810; rs1553474; rs13011582; rs17038250; rs13431289; rs7599310; rs7420778; rs12611574; rs17038148; rs2268362; rs13027322; rs17037957; rs11125208; rs17038129; rs17038302; rs10168582; rs11888021; rs17038232; rs2055570; rs11125203; rs10205229; rs17038062; rs17038097; rs17326845; rs17824877; rs17038322; rs12477940; rs11686860; rs1922482; rs2300441; rs11675317; rs12617250; rs2091788; rs17038354; rs7568374; rs1922467; rs17038095; rs10432668; rs11885931; rs6745895; rs6722885; rs17038169; rs1126076; rs12473600; rs34201686; rs13007274; rs12618107; rs13027865; rs7594633; rs6725098; rs1504187; rs17038132; rs4971881; rs11688474; rs11887125; rs11680730; rs11686941; rs13027529; rs12617499; rs17038225; rs11125200; rs17038309; rs12105926; rs17038139; rs6728155; rs13033004; rs11125209; rs13386240; rs11686474; rs10184065; rs10197617; rs1882558; rs13035743; rs6718815; rs13004711; rs17038247; rs11895457; rs11125201; rs1319837; rs9789581; rs12470147; rs6752625; rs11903279; rs1394203; rs11125212; rs13008674; rs1504179; rs17824954; rs10184020; rs7568778; rs13411539; rs13008999; rs4992637; rs12622273; rs6745854; rs1604820; rs4991812; rs17038176; rs2134810; rs2174279; rs17038143; rs12469454; rs7599845; rs6734724; rs17038300; rs989358; rs1827614; rs11125204; rs35833785; rs6737173; rs13007952; rs11688329; rs2349713; rs11891968; rs12477939; rs12618787; rs13034895; rs2241087; rs1604824; rs12620721; rs6749906; rs17038137; rs10865237; rs17038347; rs13026091; rs13004633; rs6717598; rs13411763; rs12622258; rs17771948; rs17038135; rs17038187; rs11678857; rs12477021; rs17038163; rs3892125; rs1847464; rs1504168; rs13395924; rs12622212; rs12618131; rs17038110; rs17823305; rs17822308; rs12713032; rs11125205; rs11899165; rs17038257; rs35697787; rs12622997; rs1394208; rs6733819; rs2103398; rs10180959; rs11690610; rs12614425; rs1504172; rs10190280; rs10191447; rs905666; rs17398620; rs17038310; rs11686341; rs12473601; rs4530401; rs4494797; rs1882559; rs13398926; rs7596252; rs12713038; rs17038389; rs12476685; rs986036; rs6167; rs28928870; rs1126714; rs28928871; rs6168; rs34967566; rs35443663; rs9653497; rs35311039; rs9679728; rs28804750; rs10652994; rs28478725; rs35349819; rs7582211; rs6708649; rs2103399; rs34487783; rs34543222; rs13415495; rs35028950; rs35155984; rs34370636; rs4299379; rs11901016; rs6744262; rs1922478; rs10596386; rs35317087; rs12998107; rs6760036; rs12993431; rs11680961; rs35210289; rs34439349; rs13416012; rs10439474; rs6744698; rs34025238; rs35128134; rs971830; rs36216390; rs1882554; rs35358971; rs10582992; rs6733807; rs12052611; rs35465003; rs12991974; rs11125195; rs35119659; rs1104988; rs5831022; rs12473833; rs34174059; rs9309156; rs10169885; rs28635873; rs10691636; rs34913428; rs7422758; rs11901058; rs34690820; rs5831023; rs28897393; rs11902223; rs4638837; rs28827576; rs35605088; rs34054612; rs35285121; rs3838213; rs6744573; rs2655373; rs3827492; rs28513867; rs953546; rs34377498; rs13028341; rs34704244; rs34506323; rs13432048; rs35382398; rs10181627; rs35674955; rs35694729; rs2707279; rs35738966; rs12995248; rs1291653; rs11890700; rs11125196; rs10194443; rs13027522; rs10586001; rs34158171; rs34150512; rs35876884; rs1882555; rs1604823; rs13019293; rs35608687; rs2134812; rs6730592; rs34782013; rs1290101; rs34017410; rs34226118; rs35670931; rs35629226; rs35914360; rs34350954; rs11125211; rs35905315; rs952548; rs12474496; rs13411248; rs11679050; rs10439473; rs13023561; rs34168636; rs35848948; rs34629878; rs6729758; rs10564322; rs12991688; rs13388017; rs34551844; rs34620918; rs10558428; rs34196121; rs13004077; rs11903022; rs12478831; rs35292210; rs1504164; rs905664; rs11692426; rs35052191; rs35918861; rs35549654; rs17038376; rs10612897; rs34665985; rs11358395; rs34287713; rs34196492; rs35380548; rs34250059; rs12478454; rs10645537; rs34629488; rs35544772; rs35224883; rs5831024; rs34298862; rs12989746; rs13027744; rs35462543; rs28869472; rs4387843; rs35983165; rs35756012; rs35914737; rs7593168; rs10181628; rs13024619; rs34430149; rs35916666; rs2655372; rs13031121; rs17038172; rs35712789; rs34394877; rs34018023; rs12995133; rs35714572; rs2300442; rs5831017; rs1295872; rs13019186; rs33989740; rs2882224; rs36104068; rs35236514; rs2707277; rs35724113; rs4467315; rs35557030; rs13024122; rs11883774; rs34127173; rs12999595; rs35157182; rs3082692; rs11444533; rs11684652; rs9677041; rs11889048; rs5831020; rs1950144; rs6759025; rs1295871; rs13032866; rs10451651; rs2102241; rs34987973; rs13425191; rs9711233; rs34406032; rs7562725; rs2349717; rs10530796; rs34773868; rs11890629; rs976228; rs34329354; rs13035091; rs11892641; rs35263093; rs7579827; rs34870124; rs34255462; rs6725099; rs35054706; rs4952934; rs11674572; rs35994990; rs13411685; rs13024666; rs5831016; rs35248528; rs13416651; rs2268364; rs35557262; rs11312298; rs34956197; rs34374348; rs36231301; rs11561634; rs35014852; rs35590768; rs36097756; rs11338274; rs35421994; rs35884451; rs2882158; rs12623785; rs11901066; rs9309158; rs35639630; rs1504165; rs13002554; rs34765152; rs7421065; rs11446555; rs13025969; rs11678373; rs7565474; rs34512151; rs35179417; rs5831025; rs6760046; rs10644983; rs6725466; rs35705787; rs2089119; rs36099655; rs2882223; rs5831019; rs35958678; rs9679717; rs2707278; rs36073578; rs13028329; rs35953659; rs10541638; rs35315263; rs13386744; rs35287724; rs34839582; rs34495125; rs4971638; rs28831485; rs4525743; rs13005640; rs6756514; rs34105893; rs34641522; rs12475351; rs34127690; rs13413619; rs7571021; rs2655371; rs5831015; rs34047807; rs1882556; rs35989378; rs35070498; rs10166903; rs35054867; rs34907162; rs13006263; rs34986202; rs35189218; rs35719941; rs34110902; rs7596690; rs35004985; rs6737762; rs34684515; rs5831021; rs34680327; rs5019894; rs7582152; rs4998052; rs34449959; rs34354495; rs2134813; rs7604328; rs35761126; rs1604825; rs35872152; rs11270046; rs13415815; rs5831026; rs13012535; rs10652995; rs28886356; rs34275347; rs34014225; rs7424788; rs13025970; rs13030560; rs10556305; rs13003970; rs35380100; rs4355167; rs35729500; rs35574043; rs4312534; rs5831027; rs2349718; rs2882225; rs35943964; rs34343384; rs13418454; rs6729827; rs34518771; rs1394204; rs35512125; rs6729719; rs10171892; rs10185242; rs10495963; rs11884978; rs12465216; rs12468530; rs12468889; rs12713039; rs13014229; rs13396303; rs1504161; rs1504162; rs1504163; rs17037903; rs1861168; rs1861169; rs1922465; rs1922475; rs1922476; rs2041724; rs2041725; rs2055574; rs4140979; rs4420736; rs4500983; rs4971561; rs6545085; rs6545086; rs6545087; rs6711155; rs6711198; rs6736903; rs7559066; rs7577853; rs7585723

# Macromolecular_Interacting_Partner_47_General_References:
1709010; 1301382; 1359889; 7926278; 7916967; 8747461; 9769327; 10391209; 12059813; 12930927; 12930928

# Macromolecular_Interacting_Partner_47_References:
16641147

# Macromolecular_Interacting_Partner_48_ID:
7744

# Macromolecular_Interacting_Partner_48_Name:
Hematopoietic progenitor cell antigen CD34 precursor

# Macromolecular_Interacting_Partner_48_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_48_Gene_Name:
CD34

# Macromolecular_Interacting_Partner_48_Protein_Sequence:
>Hematopoietic progenitor cell antigen CD34 precursor
MLVRRGARAGPRMPRGWTALCLLSLLPSGFMSLDNNGTATPELPTQGTFSNVSTNVSYQE
TTTPSTLGSTSLHPVSQHGNEATTNITETTVKFTSTSVITSVYGNTNSSVQSQTSVISTV
FTTPANVSTPETTLKPSLSPGNVSDLSTTSTSLATSPTKPYTSSSPILSDIKAEIKCSGI
REVKLTQGICLEQNKTSSCAEFKKDRGEGLARVLCGEEQADADAGAQVCSLLLAQSEVRP
QCLLLVLANRTEISSKLQLMKKHQSDLKKLGILDFTEQDVASHQSYSQKTLIALVTSGAL
LAVLGITGYFLMNRRSWSPTGERLGEDPYYTENGGGQGYSSGPGTSPEAQGKASVNRGAQ
ENGTGQATSRNGHSARQHVVADTEL

# Macromolecular_Interacting_Partner_48_Number_of_Residues:
385

# Macromolecular_Interacting_Partner_48_Molecular_Weight:
40717

# Macromolecular_Interacting_Partner_48_Theoretical_pI:
7.43

# Macromolecular_Interacting_Partner_48_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular process
Process:  cell adhesion
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_48_General_Function:
Not Available

# Macromolecular_Interacting_Partner_48_Specific_Function:
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins

# Macromolecular_Interacting_Partner_48_Pathway:
Not Available

# Macromolecular_Interacting_Partner_48_Reaction:
Not Available

# Macromolecular_Interacting_Partner_48_Pfam_Domain_Function:
PF06365:CD34_antigen

# Macromolecular_Interacting_Partner_48_Signals:
1-31

# Macromolecular_Interacting_Partner_48_Transmembrane_Regions:
291-311

# Macromolecular_Interacting_Partner_48_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_48_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_48_GenBank_ID_Protein:
180109

# Macromolecular_Interacting_Partner_48_SwissProt_ID:
CD34_HUMAN (P28906)

# Macromolecular_Interacting_Partner_48_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_48_Genecard_id:
CD34

# Macromolecular_Interacting_Partner_48_Geneatlas_id:
CD34

# Macromolecular_Interacting_Partner_48_hgnc_id:
HGNC:1662

# Macromolecular_Interacting_Partner_48_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_48_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_48_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_48_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_48_Gene_Sequence:
>1122 bp
ATGCCGCGGGGCTGGACCGCGCTTTGCTTGCTGAGTTTGCTGCCTTCTGGGTTCATGAGT
CTTGACAACAACGGTACTGCTACCCCAGAGTTACCTACCCAGGGAACATTTTCAAATGTT
TCTACAAATGTATCCTACCAAGAAACTACAACACCTAGTACCCTTGGAAGTACCAGCCTG
CACCCTGTGTCTCAACATGGCAATGAGGCCACAACAAACATCACAGAAACGACAGTCAAA
TTCACATCTACCTCTGTGATAACCTCAGTTTATGGAAACACAAACTCTTCTGTCCAGTCA
CAGACCTCTGTAATCAGCACAGTGTTCACCACCCCAGCCAACGTTTCAACTCCAGAGACA
ACCTTGAAGCCTAGCCTGTCACCTGGAAATGTTTCAGACCTTTCAACCACTAGCACTAGC
CTTGCAACATCTCCCACTAAACCCTATACATCATCTTCTCCTATCCTAAGTGACATCAAG
GCAGAAATCAAATGTTCAGGCATCAGAGAAGTGAAATTGACTCAGGGCATCTGCCTGGAG
CAAAATAAGACCTCCAGCTGTGCGGAGTTTAAGAAGGACAGGGGAGAGGGCCTGGCCCGA
GTGCTGTGTGGGGAGGAGCAGGCTGATGCTGATGCTGGGGCCCAGGTATGCTCCCTGCTC
CTTGCCCAGTCTGAGGTGAGGCCTCAGTGTCTACTGCTGGTCTTGGCCAACAGAACAGAA
ATTTCCAGCAAACTCCAACTTATGAAAAAGCACCAATCTGACCTGAAAAAGCTGGGGATC
CTAGATTTCACTGAGCAAGATGTTGCAAGCCACCAGAGCTATTCCCAAAAGACCCTGATT
GCACTGGTCACCTCGGGAGCCCTGCTGGCTGTCTTGGGCATCACTGGCTATTTCCTGATG
AATCGCCGCAGCTGGAGCCCCACAGGAGAAAGGCTGGGCGAAGACCCTTATTACACGGAA
AACGGTGGAGGCCAGGGCTATAGCTCAGGACCTGGGACCTCCCCTGAGGCTCAGGGAAAG
GCCAGTGTGAACCGAGGGGCTCAGAAAAACGGGACCGGCCAGGCCACCTCCAGAAACGGC
CATTCAGCAAGACAACACGTGGTGGCTGATACCGAATTGTGA

# Macromolecular_Interacting_Partner_48_GenBank_ID_Gene:
M81104

# Macromolecular_Interacting_Partner_48_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_48_Locus:
1q32

# Macromolecular_Interacting_Partner_48_SNPs:
rs28362497; rs2745950; rs3738464; rs7572; rs3820521; rs2556; rs7535242; rs2267896; rs2724400; rs1474740; rs2179634; rs2267898; rs1009896; rs2259397; rs656801; rs2250321; rs2724368; rs2796254; rs2488250; rs1204682; rs1932818; rs2745954; rs11118825; rs2745955; rs1932819; rs12029239; rs1009897; rs1932823; rs2235766; rs2724369; rs2300055; rs2267895; rs2300054; rs3738460; rs6540445; rs6667619; rs1076725; rs1973916; rs6690888; rs2724379; rs1883742; rs2262269; rs2724367; rs2466570; rs2745952; rs2745956; rs1953654; rs12566127; rs2267897; rs7522146; rs17754548; rs12748548; rs1555138; rs658347; rs1210225; rs1204681; rs2267894; rs11118880; rs2745949; rs2745958; rs671131; rs2785644; rs35359362; rs34679398; rs11804555; rs34590943; rs12135011; rs41274808; rs3178025; rs34206316; rs35963409; rs41274810; rs1803255; rs6665709; rs12730990; rs2785645; rs6664837; rs34758073; rs526254; rs12727434; rs4297292; rs1932817; rs11807028; rs41274812; rs5780411; rs6688657; rs2785646; rs35002254; rs34024357; rs11461538; rs12133878; rs28362496; rs4844396; rs35378671; rs5780412; rs28558468; rs2473652; rs11299463; rs2785647; rs28634368; rs34109724; rs7521494; rs35520266; rs4486452; rs11323111; rs35006488; rs2724372; rs2745953; rs12728601; rs2796253; rs2745957; rs5780413; rs3738461; rs579475; rs4539132; rs12404229; rs4297291; rs12733780; rs10687613; rs12408220; rs2796252; rs5780414; rs12753770; rs17009888; rs35242341; rs3043877; rs6700927; rs3834082; rs41313738; rs12118589; rs35659831; rs1076724; rs12080292; rs12088320; rs12095775; rs12753897; rs17009221; rs17009223; rs1932816; rs2073070; rs2466574; rs2485065; rs2745948; rs2745959; rs2785638; rs2785639; rs2785648; rs2785649; rs3754171; rs3754172; rs607952; rs6663269; rs6663390; rs6688357; rs6688471; rs6689062; rs6693798; rs694748; rs861475

# Macromolecular_Interacting_Partner_48_General_References:
1370171; 1374051; 7678811; 2462139; 1694174

# Macromolecular_Interacting_Partner_48_References:
16982335

# Macromolecular_Interacting_Partner_49_ID:
8388

# Macromolecular_Interacting_Partner_49_Name:
Aquaporin-2

# Macromolecular_Interacting_Partner_49_Synonyms:
AQP-2; Aquaporin-CD; AQP-CD; Water channel protein for renal collecting duct; ADH water channel; Collecting duct water channel protein; WCH-CD

# Macromolecular_Interacting_Partner_49_Gene_Name:
AQP2

# Macromolecular_Interacting_Partner_49_Protein_Sequence:
>Aquaporin2
MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALG
HISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNA
LSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTG
CSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGL
EPDTDWEEREVRRRQSVELHSPQSLPRGTKA

# Macromolecular_Interacting_Partner_49_Number_of_Residues:
271

# Macromolecular_Interacting_Partner_49_Molecular_Weight:
28838

# Macromolecular_Interacting_Partner_49_Theoretical_pI:
6.95

# Macromolecular_Interacting_Partner_49_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_49_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_49_Specific_Function:
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient

# Macromolecular_Interacting_Partner_49_Pathway:
Not Available

# Macromolecular_Interacting_Partner_49_Reaction:
Not Available

# Macromolecular_Interacting_Partner_49_Pfam_Domain_Function:
PF00230:MIP

# Macromolecular_Interacting_Partner_49_Signals:
1-31

# Macromolecular_Interacting_Partner_49_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_49_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_49_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_49_GenBank_ID_Protein:
474059

# Macromolecular_Interacting_Partner_49_SwissProt_ID:
AQP2_HUMAN (P41181)

# Macromolecular_Interacting_Partner_49_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_49_Genecard_id:
AQP2

# Macromolecular_Interacting_Partner_49_Geneatlas_id:
AQP2

# Macromolecular_Interacting_Partner_49_hgnc_id:
HGNC:634

# Macromolecular_Interacting_Partner_49_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_49_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_49_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_49_Subcellular_Location:
Cell membrane; apical cell membrane; multi- pass membrane protein. Cytoplasmic vesicle; cytoplasmic vesicle membrane; multi-pass membrane protein. Note=Shuttles from vesicles to the apical membrane

# Macromolecular_Interacting_Partner_49_Gene_Sequence:
>816 bp
ATGTGGGAGCTCCGCTCCATAGCCTTCTCCAGGGCTGTGTTCGCAGAGTTCCTGGCCACA
CTCCTCTTCGTCTTCTTTGGCCTCGGCTCTGCCCTCAACTGGCCACAGGCCCTGCCCTCT
GTGCTACAGATTGCCATGGCGTTTGGCTTGGGTATTGGCACCCTGGTACAGGCTCTGGGC
CACATAAGCGGGGCCCACATCAACCCTGCCGTGACTGTGGCCTGCCTGGTGGGCTGCCAC
GTCTCCGTTCTCCGAGCCGCCTTCTACGTGGCTGCCCAGCTGCTGGGGGCTGTGGCCGGA
GCCGCTCTGCTCCATGAGATCACGCCAGCAGACATCCGCGGGGACCTGGCTGTCAATGCT
CTCAGCAACAGCACGACGGCTGGCCAGGCGGTGACTGTGGAGCTCTTCCTGACACTGCAG
CTGGTGCTCTGCATCTTCGCCTCCACCGATGAGCGCCGCGGAGAGAACCCGGGCACCCCT
GCTCTCTCCATAGGCTTCTCCGTGGCCCTGGGCCACCTCCTTGGGATCCATTACACCGGC
TGCTCTATGAATCCTGCCCGCTCCCTGGCTCCAGCTGTCGTCACTGGCAAATTTGATGAC
CACTGGGTCTTCTGGATCGGACCCCTGGTGGGCGCCATCCTGGGCTCCCTCCTCTACAAC
TACGTGCTGTTTCCGCCAGCCAAGAGCCTGTCGGAGCGCCTGGCAGTGCTGAAGGGCCTG
GAGCCGGACACCGATTGGGAGGAGCGCGAGGTGCGACGGCGGCAGTCGGTGGAGCTGCAC
TCGCCGCAGAGCCTGCCACGGGGTACCAAGGCCTGA

# Macromolecular_Interacting_Partner_49_GenBank_ID_Gene:
Z29491

# Macromolecular_Interacting_Partner_49_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_49_Locus:
12q12-q13

# Macromolecular_Interacting_Partner_49_SNPs:
rs426496; rs35400945; rs2878771; rs10875989; rs467323; rs296766; rs1077520; rs296768; rs1077521; rs457487; rs2878772; rs7299924; rs3741559; rs371777; rs403201; rs461872; rs467199; rs439779; rs402813; rs442674; rs11834395; rs3782318; rs3759124; rs3759125; rs3759126; rs28931580; rs11169226; rs11557014; rs35872356; rs2336709; rs34335497; rs34704996; rs35104166; rs296767; rs35190790; rs34780794; rs34614799; rs1047224; rs35146277; rs965486; rs34714794; rs3782322; rs3782320; rs965487; rs34155253; rs3782319; rs410837; rs2277354; rs12372344; rs11169225; rs34119994; rs11169223; rs404117; rs389437; rs11169221; rs11836233; rs11836272; rs17124174; rs17124176; rs17124193; rs1874086; rs1893491; rs190922; rs1964676; rs2242357; rs296736; rs296742; rs296753; rs296754; rs296755; rs296756; rs296757; rs296758; rs296761; rs296762; rs372547; rs3736309; rs3759129; rs399023; rs416959; rs444124; rs455037; rs461937; rs7305290; rs7305534; rs7314734; rs7959190; rs7979167; rs923911

# Macromolecular_Interacting_Partner_49_General_References:
8140421; 7522228; 7524315; 7510718; 12194985; 8882880; 9302264; 9048343; 9402087; 9550615; 9649557; 9745427; 12191971; 12050236

# Macromolecular_Interacting_Partner_49_References:
16684923; 16844078; 16896188; 17135396

# Macromolecular_Interacting_Partner_50_ID:
8216

# Macromolecular_Interacting_Partner_50_Name:
5-hydroxytryptamine 6 receptor

# Macromolecular_Interacting_Partner_50_Synonyms:
5-HT-6; Serotonin receptor 6

# Macromolecular_Interacting_Partner_50_Gene_Name:
HTR6

# Macromolecular_Interacting_Partner_50_Protein_Sequence:
>5hydroxytryptamine 6 receptor
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN

# Macromolecular_Interacting_Partner_50_Number_of_Residues:
440

# Macromolecular_Interacting_Partner_50_Molecular_Weight:
46955

# Macromolecular_Interacting_Partner_50_Theoretical_pI:
9.02

# Macromolecular_Interacting_Partner_50_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_50_General_Function:
Not Available

# Macromolecular_Interacting_Partner_50_Specific_Function:
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs

# Macromolecular_Interacting_Partner_50_Pathway:
Not Available

# Macromolecular_Interacting_Partner_50_Reaction:
Not Available

# Macromolecular_Interacting_Partner_50_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_50_Signals:
None

# Macromolecular_Interacting_Partner_50_Transmembrane_Regions:
35-57
65-85
101-122
145-166
185-208
266-290
296-320

# Macromolecular_Interacting_Partner_50_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_50_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_50_GenBank_ID_Protein:
1162924

# Macromolecular_Interacting_Partner_50_SwissProt_ID:
5HT6R_HUMAN (P50406)

# Macromolecular_Interacting_Partner_50_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_50_Genecard_id:
HTR6

# Macromolecular_Interacting_Partner_50_Geneatlas_id:
HTR6

# Macromolecular_Interacting_Partner_50_hgnc_id:
HGNC:5301

# Macromolecular_Interacting_Partner_50_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_50_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_50_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_50_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_50_Gene_Sequence:
>1323 bp
ATGGTCCCAGAGCCGGGCCCAACCGCCAATAGCACCCCGGCCTGGGGGGCAGGGCCGCCG
TCGGCCCCGGGGGGCAGCGGCTGGGTGGCGGCCGCGCTGTGCGTGGTCATCGCGCTGACG
GCGGCGGCCAACTCGCTGCTGATCGCGCTCATCTGCACTCAGCCCGCGCTGCGCAACACG
TCCAACTTCTTCCTGGTGTCGCTCTTCACGTCTGACCTGATGGTGGGGCTGGTGGTGATG
CCGCCGGCCATGCTGAACGCGCTGTACGGGCGCTGGGTGCTGGCGCGCGGCCTCTGCCTG
CTCTGGACCGCCTTCGACGTGATGTGCTGCAGCGCCTCCATCCTCAACCTCTGCCTCATC
AGCCTGGACCGCTACCTGCTCATCCTCTCGCCGCTGCGCTACAAGCTGCGCATGACGCCC
CTGCGTGCCCTGGCCCTAGTCCTGGGCGCCTGGAGCCTCGCCGCTCTCGCCTCCTTCCTG
CCCCTGCTGCTGGGCTGGCACGAGCTGGGCCACGCACGGCCACCCGTCCCTGGCCAGTGC
CGCCTGCTGGCCAGCCTGCCTTTTGTCCTTGTGGCGTCGGGCCTCACCTTCTTCCTGCCC
TCGGGTGCCATATGCTTCACCTACTGCAGGATCCTGCTAGCTGCCCGCAAGCAGGCCGTG
CAGGTGGCCTCCCTCACCACCGGCATGGCCAGTCAGGCCTCGGAGACGCTGCAGGTGCCC
AGGACCCCACGCCCAGGGGTGGAGTCTGCTGACAGCAGGCGTCTAGCCACGAAGCACAGC
AGGAAGGCCCTGAAGGCCAGCCTGACGCTGGGCATCCTGCTGGGCATGTTCTTTGTGACC
TGGTTGCCCTTCTTTGTGGCCAACATAGTCCAGGCCGTGTGCGACTGCATCTCCCCAGGC
CTCTTCGATGTCCTCACATGGCTGGGTTACTGTAACAGCACCATGAACCCCATCATCTAC
CCACTCTTCATGCGGGACTTCAAGCGGGCGCTGGGCAGGTTCCTGCCATGTCCACGCTGT
CCCCGGGAGCGCCAGGCCAGCCTGGCCTCGCCATCACTGCGCACCTCTCACAGCGGCCCC
CGGCCCGGCCTTAGCCTACAGCAGGTGCTGCCGCTGCCCCTGCCGCCGGACTCAGATTCG
GACTCAGACGCAGGCTCAGGCGGCTCCTCGGGCCTGCGGCTCACGGCCCAGCTGCTGCTT
CCTGGCGAGGCCACCCAGGACCCCCCGCTGCCCACCAGGGCCGCTGCCGCCGTCAATTTC
TTCAACATCGACCCCGCGGAGCCCGAGCTGCGGCCGCATCCACTTGGCATCCCCACGAAC
TGA

# Macromolecular_Interacting_Partner_50_GenBank_ID_Gene:
L41147

# Macromolecular_Interacting_Partner_50_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_50_Locus:
1p36-p35

# Macromolecular_Interacting_Partner_50_SNPs:
rs6322; rs1805054; rs10917509; rs9659997; rs4912138; rs6684942; rs12691495; rs6699866; rs3790758; rs3790757; rs4912142; rs4912141; rs3790756; rs6658108; rs4912143; rs2872594; rs3790754; rs2314332; rs6671732; rs4912139; rs4912140; rs12569086; rs12562239; rs12145364; rs10917512; rs8192530; rs8192533; rs6321; rs8192529; rs6660215; rs8192534; rs34308152; rs8192531; rs1320982; rs35085783; rs10917510; rs34145209; rs3790752; rs8192532; rs34322917; rs34169506; rs35845491; rs11312913; rs34148002; rs3790753; rs10917511; rs10582325; rs35552433; rs3838431; rs3790751; rs35289324; rs36070236; rs35519421; rs11355184; rs10702215; rs34859495; rs34599325; rs12024520; rs34364768; rs35691535; rs6702953; rs35478529; rs35175475; rs34470217; rs6703842; rs10564587; rs10596328; rs41264099; rs35903019; rs10159394; rs1049959; rs1050027; rs10917514; rs10917517; rs11578468; rs11581887; rs11804138; rs12747702; rs16822721; rs16822729; rs16822732; rs1801523; rs1883564; rs1977101; rs2143291; rs2143292; rs2294630; rs2854104; rs2854105; rs3087566; rs3170688; rs3813987; rs4912014; rs4912015; rs6693503; rs7527271; rs7533981; rs7543480; rs9064

# Macromolecular_Interacting_Partner_50_General_References:
8522988; 7656980

# Macromolecular_Interacting_Partner_50_References:
16865095

# Macromolecular_Interacting_Partner_51_ID:
7891

# Macromolecular_Interacting_Partner_51_Name:
Urocortin precursor

# Macromolecular_Interacting_Partner_51_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_51_Gene_Name:
UCN

# Macromolecular_Interacting_Partner_51_Protein_Sequence:
>Urocortin precursor
MRQAGRAALLAALLLLVQLCPGSSQRSPEAAGVQDPSLRWSPGARNQGGGARALLLLLAE
RFPRRAGPGRLGLGTAGERPRRDNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFD
SVGK

# Macromolecular_Interacting_Partner_51_Number_of_Residues:
124

# Macromolecular_Interacting_Partner_51_Molecular_Weight:
13459

# Macromolecular_Interacting_Partner_51_Theoretical_pI:
12.20

# Macromolecular_Interacting_Partner_51_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_51_General_Function:
Not Available

# Macromolecular_Interacting_Partner_51_Specific_Function:
Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF Receptor types 1, 2-alpha, and 2-beta

# Macromolecular_Interacting_Partner_51_Pathway:
Not Available

# Macromolecular_Interacting_Partner_51_Reaction:
Not Available

# Macromolecular_Interacting_Partner_51_Pfam_Domain_Function:
PF00473:CRF

# Macromolecular_Interacting_Partner_51_Signals:
1-25

# Macromolecular_Interacting_Partner_51_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_51_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_51_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_51_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_51_SwissProt_ID:
UCN1_HUMAN (P55089)

# Macromolecular_Interacting_Partner_51_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_51_Genecard_id:
UCN

# Macromolecular_Interacting_Partner_51_Geneatlas_id:
UCN

# Macromolecular_Interacting_Partner_51_hgnc_id:
HGNC:12516

# Macromolecular_Interacting_Partner_51_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_51_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_51_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_51_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_51_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_51_GenBank_ID_Gene:
AF038633

# Macromolecular_Interacting_Partner_51_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_51_Locus:
2p23-p21

# Macromolecular_Interacting_Partner_51_SNPs:
Not Available

# Macromolecular_Interacting_Partner_51_General_References:
8612563; 9628819

# Macromolecular_Interacting_Partner_51_References:
16920724

# Macromolecular_Interacting_Partner_52_ID:
8236

# Macromolecular_Interacting_Partner_52_Name:
Protein ALEX

# Macromolecular_Interacting_Partner_52_Synonyms:
Alternative gene product encoded by XL-exon

# Macromolecular_Interacting_Partner_52_Gene_Name:
GNAS

# Macromolecular_Interacting_Partner_52_Protein_Sequence:
>Protein 
ALEXMMARPVDPQRSPDPTFRSSTRHSGKLEPMEATAHLLRKQCPSRLNSPAWEASGLHW
SSLDSPVGSMQALRPSAQHSWSPEPSVVPDQAWEDTALHQKKLCPLSLTSLPREAAVNFS
YRSQTLLQEAQVLQGSPELLPRSPKPSGLQRLAPEEATALPLRRLCHLSLMEKDLGTTAH
PRGFPELSHKSTAAASSRQSRPRVRSASLPPRTRLPSGSQAPSAAHPKRLSDLLLTSRAA
APGWRSPDPRSRLAAPPLGSTTLPSTWTAPQSRLTARPSRSPEPQIRESEQRDPQLRRKQ
QRWKEPLMPRREEKYPLRGTDPLPPGQPQRIPLPGQPLQPQPILTPGQPQKIPTPGQHQP
ILTPGHSQPIPTPGQPLPPQPIPTPGRPLTPQPIPTPGRPLTPQPIQMPGRPLRLPPPLR
LLRPGQPMSPQLRQTQGLPLPQPLLPPGQPKSAGRPLQPLPPGPDARSISDPPAPRSRLP
IRLLRGLLARLPGGASPRAAAAAACTTMKGWPAATMTPAETSPTMGPPDASAGFSIGEIA
AAESPSATYSATFSCKPSGAASVDLRVPSPKPRALSRSRRYPWRRSADRCAKKPWRSGPR
SAQRRNAVSSSTNNSRTKRWATCVRTACCF

# Macromolecular_Interacting_Partner_52_Number_of_Residues:
626

# Macromolecular_Interacting_Partner_52_Molecular_Weight:
67949

# Macromolecular_Interacting_Partner_52_Theoretical_pI:
12.07

# Macromolecular_Interacting_Partner_52_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_52_General_Function:
Not Available

# Macromolecular_Interacting_Partner_52_Specific_Function:
May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame

# Macromolecular_Interacting_Partner_52_Pathway:
Not Available

# Macromolecular_Interacting_Partner_52_Reaction:
Not Available

# Macromolecular_Interacting_Partner_52_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_52_Signals:
None

# Macromolecular_Interacting_Partner_52_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_52_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_52_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_52_GenBank_ID_Protein:
10086223

# Macromolecular_Interacting_Partner_52_SwissProt_ID:
ALEX_HUMAN (P84996)

# Macromolecular_Interacting_Partner_52_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_52_Genecard_id:
GNAS

# Macromolecular_Interacting_Partner_52_Geneatlas_id:
GNAS

# Macromolecular_Interacting_Partner_52_hgnc_id:
HGNC:4392

# Macromolecular_Interacting_Partner_52_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_52_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_52_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_52_Subcellular_Location:
Cell membrane; peripheral membrane protein. Cell projection; ruffle. Note=Predominantly associated with cell membrane ruffles (By similarity)

# Macromolecular_Interacting_Partner_52_Gene_Sequence:
>738 bp
ATGGATCGGAGGTCCCGGGCTCAGCAGTGGCGCCGAGCTCGCCATAATTACAACGACCTG
TGCCCGCCCATAGGCCGCCGGGCAGCCACCGCGCTCCTCTGGCTCTCCTGCTCCATCGCG
CTCCTCCGCGCCCTTGCCACCTCCAACGCCCGTGCCCAGCAGCGCGCGGCTGCCCAACAG
CGCCGGAGCTTCCTTAACGCCCACCACCGCTCCGGCGCCCAGGTATTCCCTGAGTCCCCC
GAATCGGAATCTGACCACGAGCACGAGGAGGCAGACCTTGAGCTGTCCCTCCCCGAGTGC
CTAGAGTACGAGGAAGAGTTCGACTACGAGACCGAGAGCGAGACCGAGTCCGAAATCGAG
TCCGAGACCGACTTCGAGACCGAGCCTGAGACCGCCCCCACCACTGAGCCCGAGACCGAG
CCTGAAGACGATCGCGGCCCGGTGGTGCCCAAGCACTCCACCTTCGGCCAGTCCCTCACC
CAGCGTCTGCACGCTCTCAAGTTGCGAAGCCCCGACGCCTCCCCAAGTCGCGCGCCGCCC
AGCACTCAGGAGCCCCAGAGCCCCAGGGAAGGGGAGGAGCTCAAGCCCGAGGACAAAGAT
CCAAGGGACCCCGAAGAGTCGAAGGAGCCCAAGGAGGAGAAGCAGCGGCGTCGCTGCAAG
CCAAAGAAGCCCACCCGCCGTGACGCGTCCCCGGAGTCCCCTTCCAAAAAGGGACCCATC
CCCATCCGGCGTCACTAA

# Macromolecular_Interacting_Partner_52_GenBank_ID_Gene:
AL132655

# Macromolecular_Interacting_Partner_52_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_52_Locus:
20q13.3

# Macromolecular_Interacting_Partner_52_SNPs:
rs7121; rs3730166; rs11907071; rs3730171; rs35287986; rs8386; rs234629; rs234628; rs2057291; rs234630; rs919196; rs6092704; rs4810148; rs6026576; rs6070638; rs4812042; rs8121252; rs6026567; rs6026565; rs2295583; rs12625436; rs6026584; rs3730168; rs6123836; rs6026593; rs15754; rs3730169; rs13831; rs12479894; rs8125112; rs6128461; rs1407040; rs6123837; rs3730176; rs2180696; rs8118341; rs6100260; rs6026591; rs919197; rs11699704; rs7271854; rs8114689; rs6064716; rs3730170; rs3730177; rs3787493; rs3730164; rs6026578; rs968519; rs234632; rs6092702; rs3730173; rs2145288; rs3730165; rs6026574; rs6026592; rs3730174; rs1004902; rs3730172; rs234631; rs3730163; rs6100257; rs6128459; rs7347670; rs17804083; rs6026569; rs6100269; rs6092701; rs7273251; rs1064747; rs12481583; rs6026563; rs11698680; rs6026579; rs9679921; rs6026580; rs6026564; rs12624462; rs11697466; rs6026562; rs4810149; rs2023512; rs6015391; rs6026585; rs3787496; rs6100261; rs6026566; rs6026568; rs6015400; rs1058909; rs7271759; rs4481060; rs12481574; rs6070647; rs11554273; rs11554278; rs1802357; rs11554274; rs3205253; rs8986; rs1802356; rs6026596; rs1800903; rs1800902; rs11554277; rs1800901; rs11554269; rs6026588; rs34300095; rs35444156; rs6064721; rs6015392; rs1064746; rs35813452; rs6128449; rs6128450; rs13433254; rs11470545; rs34378812; rs6100255; rs3833329; rs6015396; rs35248909; rs6026581; rs6064723; rs6100265; rs3736779; rs34670953; rs35582814; rs35580639; rs34214227; rs7348876; rs6064718; rs6026594; rs13038324; rs6026577; rs35309658; rs6100268; rs6128453; rs6123835; rs7348311; rs11475102; rs10544126; rs6026570; rs6015398; rs6128457; rs41276956; rs11477757; rs13038325; rs6026572; rs13045165; rs34891980; rs6070637; rs35201164; rs5842245; rs3746705; rs3199305; rs6100262; rs11468197; rs35714680; rs6026598; rs12162443; rs6070640; rs15952; rs6026573; rs34016603; rs6026595; rs6128452; rs2742268; rs28763888; rs6070639; rs6100264; rs15054; rs7348872; rs35543533; rs11086659; rs6015399; rs4812041; rs3215656; rs6015401; rs6015390; rs34377819; rs6123839; rs35193826; rs28568499; rs6128462; rs2057290; rs6026575; rs6015394; rs6100253; rs6128454; rs6100266; rs11554268; rs6064722; rs3833328; rs6015397; rs35727453; rs6128458; rs34886636; rs6100256; rs8183668; rs11554271; rs1064745; rs6015393; rs6064719; rs34197054; rs6070644; rs35510645; rs36075195; rs6123838; rs6100267; rs34603862; rs6100258; rs35919668; rs6026586; rs34694645; rs6026571; rs2742269; rs3207520; rs6064717; rs11481552; rs6092703; rs16982305; rs34087097; rs6070646; rs34008332; rs9679845; rs2903070; rs6128451; rs6015402; rs7347598; rs34589209; rs35123375; rs35584789; rs6128456; rs11474082; rs34407281; rs5842244; rs35170166; rs15053; rs11470652; rs11554267; rs6026587; rs13044933; rs3215657; rs6015395; rs6026582; rs6128460; rs11474350; rs6026583; rs1321459; rs3198765; rs6100259; rs11086660; rs6100254; rs6070641; rs6100263; rs11699292; rs11476551; rs6026589; rs35856331; rs6015403; rs35113254; rs35132236; rs11477382; rs6026597; rs41305811; rs41305799; rs41276954; rs41312296; rs1800904; rs34058228; rs6070650; rs6070649; rs36075632; rs6070648; rs11086658; rs151331; rs1800900; rs1800905; rs234618; rs234621; rs234623; rs234625; rs234626; rs234627; rs2742267; rs2742270; rs2742271; rs2742272; rs2742273; rs2742274; rs2742275; rs2752944; rs2752945; rs2752946; rs2752947; rs2753642; rs2753644; rs2753645; rs2983655; rs3761262; rs3761263; rs3761264; rs4810147; rs4812036; rs4812040; rs6015384; rs6015385; rs6015386; rs6015389; rs6015404; rs6026548; rs6026550; rs6026551; rs6026553; rs6026560; rs6026561; rs6064712; rs6064714; rs6064715; rs6064726; rs6070634; rs6092705; rs6092706; rs6100270; rs6123832; rs6128446; rs6128447; rs965808

# Macromolecular_Interacting_Partner_52_General_References:
11780052

# Macromolecular_Interacting_Partner_52_References:
16720661; 16767104; 17004068

# Macromolecular_Interacting_Partner_53_ID:
8377

# Macromolecular_Interacting_Partner_53_Name:
Myocyte-specific enhancer factor 2A

# Macromolecular_Interacting_Partner_53_Synonyms:
Serum response factor-like protein 1

# Macromolecular_Interacting_Partner_53_Gene_Name:
MEF2A

# Macromolecular_Interacting_Partner_53_Protein_Sequence:
>Myocytespecific enhancer factor 2
AMGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYAS
TDMDKVLLKYTEYNEPHESRTNSDIVEALNKKEHRGCDSPDPDTSYVLTPHTEEKYKKIN
EEFDNMMRNHKIAPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDSSM
LSPPQTTLHRNVSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNLI
GATGANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPSSKGMMPPLSEEEELELNTQ
RISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGML
SLGQVSAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPSGF
QQQQQQQQQQQPPPPPQPQPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHS
PIVLGRPPNTEDRESPSVKRMRMDAWVT

# Macromolecular_Interacting_Partner_53_Number_of_Residues:
507

# Macromolecular_Interacting_Partner_53_Molecular_Weight:
54812

# Macromolecular_Interacting_Partner_53_Theoretical_pI:
8.08

# Macromolecular_Interacting_Partner_53_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_53_General_Function:
Not Available

# Macromolecular_Interacting_Partner_53_Specific_Function:
Transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription

# Macromolecular_Interacting_Partner_53_Pathway:
Not Available

# Macromolecular_Interacting_Partner_53_Reaction:
Not Available

# Macromolecular_Interacting_Partner_53_Pfam_Domain_Function:
PF00319:SRF-TF

# Macromolecular_Interacting_Partner_53_Signals:
None

# Macromolecular_Interacting_Partner_53_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_53_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_53_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_53_GenBank_ID_Protein:
34536

# Macromolecular_Interacting_Partner_53_SwissProt_ID:
MEF2A_HUMAN (Q02078)

# Macromolecular_Interacting_Partner_53_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_53_Genecard_id:
MEF2A

# Macromolecular_Interacting_Partner_53_Geneatlas_id:
MEF2A

# Macromolecular_Interacting_Partner_53_hgnc_id:
HGNC:6993

# Macromolecular_Interacting_Partner_53_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_53_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_53_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_53_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_53_Gene_Sequence:
>1524 bp
ATGGGGCGGAAGAAAATACAAATCACACGCATAATGGATGAAAGGAACCGACAGGTCACT
TTTACAAAGAGAAAGTTTGGATTAATGAAGAAAGCCTATGAACTTAGTGTGCTCTGTGAC
TGTGAAATAGCACTCATCATTTTCAACAGCTCTAACAAACTGTTTCAATATGCTAGCACT
GATATGGACAAAGTTCTTCTCAAGTATACAGAATATAATGAACCTCATGAAAGCAGAACC
AACTCGGATATTGTTGAGGCTCTGAACAAGAAGGAACACAGAGGGTGCGACAGCCCAGAC
CCTGATACTTCATATGTGCTAACTCCACATACAGAAGAAAAATATAAAAAAATTAATGAG
GAATTTGATAATATGATGCGGAATCATAAAATCGCACCTGGTCTGCCACCTCAGAACTTT
TCAATGTCTGTCACAGTTCCAGTGACCAGCCCCAATGCTTTGTCCTACACTAACCCAGGG
AGTTCACTGGTGTCCCCATCTTTGGCAGCCAGCTCAACGTTAACAGATTCAAGCATGCTC
TCTCCACCTCAAACCACATTACATAGAAATGTGTCTCCTGGAGCTCCTCAGAGACCACCA
AGTACTGGCAATGCAGGTGGGATGTTGAGCACTACAGACCTCACAGTGCCAAATGGAGCT
GGAAGCAGTCCAGTGGGGAATGGATTTGTAAACTCAAGAGCTTCTCCAAATTTGATTGGA
GCTACTGGTGCAAATAGCTTAGGCAAAGTCATGCCTACAAAGTCTCCCCCTCCACCAGGT
GGTGGTAATCTTGGAATGAACAGTAGGAAACCAGATCTTCGAGTTGTCATCCCCCCTTCA
AGCAAGGGCATGATGCCTCCACTATCGGAGGAAGAGGAATTGGAGTTGAACACCCAAAGG
ATCAGTAGTTCTCAAGCCACTCAACCTCTTGCTACCCCAGTCGTGTCTGTGACAACCCCA
AGCTTGCCTCCGCAAGGACTTGTGTACTCAGCAATGCCGACTGCCTACAACACTGATTAT
TCACTGACCAGCGCTGACCTGTCAGCCCTTCAAGGCTTCAACTCGCCAGGAATGCTGTCG
CTGGGACAGGTGTCGGCCTGGCAGCAGCACCACCTAGGACAAGCAGCCCTCAGCTCTCTT
GTTGCTGGAGGGCAGTTATCTCAGGGTTCCAATTTATCCATTAATACCAACCAAAACATC
AGCATCAAGTCCGAACCGATTTCACCTCCTCGGGATCGTATGACCCCATCGGGCTTCCAG
CAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCCGCCGCCACCACCGCAGCCCCAGCCACAA
CCCCCGCAGCCCCAGCCCCGACAGGAAATGGGGCGCTCCCCTGTGGACAGTCTGAGCAGC
TCTAGTAGCTCCTATGATGGCAGTGATCGGGAGGATCCACGGGGCGACTTCCATTCTCCA
ATTGTGCTTGGCCGACCCCCAAACACTGAGGACAGAGAAAGCCCTTCTGTAAAGCGAATG
AGGATGGACGCGTGGGTGACCTAA

# Macromolecular_Interacting_Partner_53_GenBank_ID_Gene:
X68505

# Macromolecular_Interacting_Partner_53_Chromosome_Location:
Chromosome:15

# Macromolecular_Interacting_Partner_53_Locus:
15q26

# Macromolecular_Interacting_Partner_53_SNPs:
rs325400; rs325408; rs34851361; rs3730059; rs325407; rs4965260; rs8036677; rs2570816; rs2570933; rs2570932; rs2570938; rs2164058; rs2581474; rs7181767; rs2570803; rs10902549; rs11247118; rs7181542; rs2570809; rs8030451; rs2570814; rs2570934; rs7172418; rs12912791; rs11629927; rs12101537; rs8024784; rs2570810; rs10438475; rs13379828; rs11635271; rs325413; rs325411; rs4965533; rs4965536; rs1991921; rs170521; rs8042600; rs2033545; rs325409; rs188977; rs191256; rs8040915; rs1036320; rs2581473; rs897073; rs7496677; rs325404; rs2581470; rs182730; rs8029326; rs3743180; rs325402; rs170522; rs325403; rs325393; rs2117309; rs11631947; rs3730280; rs2033547; rs11247120; rs11247119; rs2570930; rs9888651; rs12593522; rs325405; rs12591308; rs8024380; rs8032587; rs325410; rs10468175; rs12438623; rs4965534; rs2290446; rs2581472; rs3784450; rs8037206; rs8029296; rs2033546; rs1019974; rs2570817; rs2570808; rs8029516; rs2123930; rs12906668; rs325390; rs8034889; rs167805; rs12913830; rs11247122; rs12592092; rs325388; rs12595285; rs12442996; rs13379510; rs12901291; rs325385; rs2862870; rs325398; rs12101528; rs12899541; rs8030814; rs12593181; rs325397; rs4564541; rs2902349; rs325401; rs2862869; rs2053118; rs325386; rs7167042; rs13329194; rs12916000; rs4965535; rs2570929; rs2570935; rs12591986; rs325392; rs4965532; rs12593785; rs12913446; rs12595502; rs2570923; rs2570799; rs10152966; rs1454315; rs325399; rs7176008; rs3730283; rs3803420; rs34195807; rs34651845; rs34247744; rs12910803; rs34494152; rs35357315; rs34981499; rs28716877; rs34835966; rs35343866; rs34667231; rs35070052; rs2862871; rs28435945; rs12905823; rs36125809; rs1059750; rs34423995; rs2570802; rs35786772; rs34857731; rs12439839; rs34021209; rs12050750; rs35301089; rs34470992; rs34765675; rs35838163; rs2436841; rs28838709; rs12900424; rs2570811; rs34507751; rs35125832; rs2581462; rs4417534; rs11629881; rs12901057; rs11855867; rs34904560; rs35655388; rs4965529; rs28409526; rs10628004; rs36041004; rs28661025; rs34893868; rs35363728; rs12324818; rs28557165; rs12324876; rs34756453; rs12910950; rs2570937; rs35285959; rs28444186; rs34204669; rs10220854; rs2581471; rs28730473; rs35395700; rs6145707; rs33997705; rs34161626; rs3198309; rs325391; rs3216755; rs1135562; rs1135572; rs2570813; rs28530556; rs2570826; rs1135565; rs34659454; rs34901184; rs35043171; rs35480704; rs1816459; rs35745156; rs11299840; rs35613840; rs7170276; rs9888661; rs1135560; rs28371043; rs35485880; rs34883016; rs1135566; rs35190253; rs34679026; rs325395; rs1135559; rs13379841; rs34235892; rs34101672; rs35441914; rs34219550; rs8042359; rs35295124; rs34753858; rs34779575; rs34752902; rs12902163; rs34380257; rs11289926; rs28603011; rs10048028; rs28600203; rs2439248; rs35134205; rs325389; rs8182059; rs2570936; rs7170574; rs1135563; rs3784452; rs2017837; rs2570812; rs35980277; rs3198311; rs4572373; rs28405185; rs12902359; rs34131461; rs3198310; rs35025766; rs34756251; rs35585008; rs12910796; rs28623598; rs2570815; rs2570822; rs7170567; rs35354321; rs12898379; rs35616291; rs3198317; rs28452285; rs325415; rs7161858; rs1055899; rs4482263; rs34659782; rs28641735; rs35685235; rs34209263; rs3979130; rs34294935; rs1135564; rs28520235; rs28451734; rs1135567; rs28686815; rs34462447; rs4965531; rs11429799; rs10618159; rs28491145; rs34310534; rs4408523; rs3208173; rs3730279; rs28716652; rs34643915; rs34910783; rs1135569; rs34207553; rs1135571; rs10573513; rs2436842; rs12324514; rs28589335; rs4383123; rs34937961; rs12906453; rs34568746; rs34242067; rs325394; rs28752072; rs28712314; rs34987456; rs9806301; rs1135570; rs35487956; rs36110737; rs2862868; rs12907697; rs34809512; rs7168976; rs3979129; rs28479837; rs3730278; rs34877797; rs1135561; rs3730281; rs28497795; rs1135568; rs2902350; rs12903247; rs2053119; rs28450128; rs11384687; rs1136937; rs325384; rs34443706; rs34228160; rs8028444; rs36095770; rs325396; rs3198312; rs325412; rs11321800; rs34870501; rs34796590; rs325387; rs34440493; rs35410986; rs35149933; rs12917141; rs34769283; rs35947095; rs1136940; rs35026017; rs1059755; rs1059758; rs2581463; rs1059757; rs1059759; rs1059760; rs11247116; rs11247123; rs12915690; rs12916210; rs1808723; rs2012129; rs2603229; rs325380; rs325381; rs325382; rs325383; rs325406; rs325414; rs7162940; rs7163683; rs7179518; rs7183836; rs8035314; rs8038364; rs897074

# Macromolecular_Interacting_Partner_53_General_References:
1516833; 1748287; 10487761

# Macromolecular_Interacting_Partner_53_References:
16870618; 17108111

# Macromolecular_Interacting_Partner_54_ID:
7915

# Macromolecular_Interacting_Partner_54_Name:
cAMP-responsive element modulator

# Macromolecular_Interacting_Partner_54_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_54_Gene_Name:
CREM

# Macromolecular_Interacting_Partner_54_Protein_Sequence:
>cAMPresponsive element modulator
MTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVSVAGSGTRRGSPAVTLVQL
PSGQTIHVQGVIQTPQPWVIQSSEIHTVQVAAIAETDESAESEGVIDSHKRREILSRRPS
YRKILNELSSDVPGVPKIEEERSEEEGTPPSIATMAVPTSIYQTSTGQYIAIAQGGTIQI
SNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFVPGSQVVVQDEETELAP
SHMAAATGDMPTYQIRAPTAALPQGVVMAASPGSLHSPQQLAEEATRKRELRLMKNREAA
KECRRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDICSPKTDY

# Macromolecular_Interacting_Partner_54_Number_of_Residues:
345

# Macromolecular_Interacting_Partner_54_Molecular_Weight:
37006

# Macromolecular_Interacting_Partner_54_Theoretical_pI:
5.26

# Macromolecular_Interacting_Partner_54_GO_Classification:
>>>
Function:  protein binding
Function:  transcription factor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_54_General_Function:
Not Available

# Macromolecular_Interacting_Partner_54_Specific_Function:
This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREM alpha, beta, and gamma isoforms are antagonists of the cAMP transcriptional response, while the delta isoform is an activator

# Macromolecular_Interacting_Partner_54_Pathway:
Not Available

# Macromolecular_Interacting_Partner_54_Reaction:
Not Available

# Macromolecular_Interacting_Partner_54_Pfam_Domain_Function:
PF00170:bZIP_1;
PF02173:pKID

# Macromolecular_Interacting_Partner_54_Signals:
None

# Macromolecular_Interacting_Partner_54_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_54_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_54_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_54_GenBank_ID_Protein:
8248905

# Macromolecular_Interacting_Partner_54_SwissProt_ID:
CREM_HUMAN (Q03060)

# Macromolecular_Interacting_Partner_54_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_54_Genecard_id:
CREM

# Macromolecular_Interacting_Partner_54_Geneatlas_id:
CREM

# Macromolecular_Interacting_Partner_54_hgnc_id:
HGNC:2352

# Macromolecular_Interacting_Partner_54_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_54_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_54_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_54_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_54_Gene_Sequence:
>999 bp
ATGACCATGGAAACAGTTGAATCCCAGCATGATGGAAGTATAACAGCTTCTTTGACAGAG
AGCAAGTCTGCTCATGTGCAGACTCAGACTGGGCAAATTTCAATCCCTGCTTTAGCTCAG
TGCAGTGAGCTGAGATCAGGCACCAGAAGAGGCTCCCCAGCTGTAACTCTAGTGCAGTTA
CCTTCGGGCCAAACTATACATGTCCAGGGAGTAATTCAGACACCACAGCCATGGGTTATT
CAGTCATCAGAAATACACACCGTTCAGGTAGCAGCAATTGCAGAGACAGATGAATCTGCA
GAATCAGAAGGTGTAATTGATTCTCATAAACGTAGAGAAATCCTTTCACGAAGACCCTCT
TATAGGAAAATACTGAATGAACTGTCCTCTGATGTGCCTGGTGTTCCCAAGATTGAAGAA
GAGAGATCAGAGGAAGAAGGAACACCACCTAGTATTGCTACCATGGCAGTACCAACTAGC
ATATATCAGACTAGCACGGGGCAATACATTGCTATAGCCCAAGGTGGAACAATCCAGATT
TCTAACCCAGGATCTGATGGTGTTCAGGGACTGCAGGCATTAACAATGACAAATTCAGGA
GCTCCTCCACCAGGTGCTACAATTGTACAGTACGCAGCACAATCAGCTGATGGCACACAG
CAGTTCTTTGTCCCAGGCAGCCAGGTTGTTGTTCAAGCTGCCACTGGTGACATGCCAACT
TACCAGATCCGAGCTCCTACTGCTGCTTTGCCACAGGGAGTGGTGATGGCTGCATCGCCC
GGAAGTTTGCACAGTCCCCAGCAGCTGGCAGAAGAAGCAACACGCAAACGAGAGCTGAGG
CTAATGAAAAACAGAGAAGCTGCCCGGGAGTGTCGCAGGAAGAAGAAAGAATATGTCAAA
TGTCTTGAAAATCGTGTGGCTGTGCTTGAAAACCAAAACAAGACTCTCATTGAGGAACTC
AAGGCCCTCAAAGATCTTTATTGCCATAAAGTAGAGTAA

# Macromolecular_Interacting_Partner_54_GenBank_ID_Gene:
S68271

# Macromolecular_Interacting_Partner_54_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_54_Locus:
10p11.21

# Macromolecular_Interacting_Partner_54_SNPs:
rs1804604; rs11010115; rs2295415; rs1545757; rs1057108; rs10827492; rs11592356; rs2384352; rs12761675; rs7079536; rs12775799; rs2384353; rs6481941; rs4934535; rs10508816; rs12769484; rs1213392; rs7913615; rs4934734; rs12260130; rs1531550; rs11594771; rs16935907; rs12768323; rs11597746; rs11592925; rs878264; rs4934538; rs4934536; rs7079691; rs17499780; rs17591135; rs17583945; rs16935904; rs11594196; rs1478463; rs12770381; rs877779; rs4934537; rs4294520; rs16935888; rs12769575; rs7079896; rs7077242; rs4934539; rs17499247; rs17499811; rs11592886; rs9783159; rs10827493; rs4934540; rs10827491; rs1213384; rs1213386; rs11010116; rs11010121; rs4934731; rs7070427; rs3780886; rs12247825; rs11010103; rs17591163; rs12248934; rs16915805; rs9703848; rs12762493; rs17575347; rs2505639; rs12258829; rs16935902; rs10827488; rs16935891; rs12264697; rs12255694; rs11598666; rs17583959; rs12777517; rs11010107; rs1213393; rs12775548; rs12242154; rs16935890; rs11010122; rs11010123; rs11592037; rs1548098; rs34779708; rs10128529; rs12773647; rs7916992; rs2045913; rs16915801; rs12771399; rs9665538; rs1213385; rs7919064; rs10827494; rs12264698; rs16935910; rs16935909; rs4934732; rs12570645; rs12771997; rs11010113; rs16935889; rs12780255; rs11595890; rs12251203; rs7079389; rs9663856; rs3004217; rs12265597; rs9783156; rs11010110; rs10827489; rs1148247; rs4934735; rs7922030; rs4934736; rs17591781; rs17500582; rs17591857; rs12245208; rs1148248; rs12259954; rs1148246; rs17854162; rs1141357; rs11545324; rs11556239; rs1141356; rs34227693; rs1064262; rs1064263; rs7907183; rs35421708; rs11345392; rs34001864; rs7077139; rs35915765; rs34929610; rs11343403; rs2045914; rs12260066; rs12098275; rs11315041; rs11010117; rs12252595; rs12761577; rs34957801; rs34802396; rs12571827; rs34496083; rs35855242; rs28874918; rs12268303; rs35017939; rs41313822; rs7342010; rs35808464; rs10655606; rs7358222; rs34337323; rs9336981; rs34842917; rs35403802; rs34780156; rs7077882; rs34348266; rs35872146; rs12762124; rs7090722; rs35512416; rs35404510; rs4934733; rs1234915; rs12784482; rs34595862; rs35398693; rs35683317; rs11545325; rs12359676; rs34364693; rs34110002; rs12267742; rs35635389; rs7903306; rs34427694; rs12240732; rs35193920; rs12250973; rs12240567; rs11289474; rs35168556; rs11819685; rs11010111; rs12267862; rs12571487; rs11010104; rs34415380; rs35079558; rs2045919; rs5784443; rs28617410; rs12773494; rs12776932; rs34569048; rs10639646; rs28579978; rs35714830; rs35557860; rs12252667; rs1213391; rs35133865; rs11010106; rs12775829; rs17590863; rs28613958; rs34209038; rs11360739; rs34148312; rs34576035; rs34122347; rs35413057; rs12355627; rs34879823; rs12767299; rs10528009; rs12250038; rs28711067; rs12771983; rs34244298; rs35324814; rs7917684; rs28685284; rs35814343; rs35437684; rs35146199; rs1213390; rs34840934; rs11010118; rs1213389; rs3780885; rs12778773; rs11296111; rs12771827; rs35550382; rs34829879; rs28437755; rs12268125; rs12762891; rs34630580; rs12257117; rs35532709; rs12774169; rs12220385; rs12260594; rs35818618; rs34513310; rs34876468; rs35126129; rs35555160; rs12218927; rs34532646; rs35470157; rs33981809; rs35847586; rs28758480; rs12259916; rs2505641; rs28662284; rs34093691; rs35698417; rs34319028; rs11344270; rs34539266; rs34242689; rs35171876; rs11010120; rs11594002; rs28687233; rs34556873; rs34883984; rs1545756; rs11441074; rs12241465; rs34776628; rs12098283; rs36146013; rs5784442; rs11010112; rs34320503; rs34577012; rs35518830; rs1213388; rs35071210; rs34992585; rs4934534; rs34426986; rs12770114; rs11476558; rs2505640; rs12782948; rs11010105; rs7917619; rs34286716; rs41306322; rs34222082; rs12269673; rs35286214; rs35715887; rs41276100; rs35798639; rs7895010; rs10827487; rs11010101; rs11010102; rs11010125; rs11592567; rs11597913; rs11598685; rs11598690; rs11599606; rs11599920; rs1213387; rs12252639; rs12765063; rs17653666; rs2045915; rs2045916; rs2045917; rs2045918; rs34247508; rs35777088; rs3740082; rs4934730; rs7086503; rs7902166

# Macromolecular_Interacting_Partner_54_General_References:
7916662; 1461747

# Macromolecular_Interacting_Partner_54_References:
16946004; 16962714; 17056544; 17059558

# Macromolecular_Interacting_Partner_55_ID:
8340

# Macromolecular_Interacting_Partner_55_Name:
Caveolin-1

# Macromolecular_Interacting_Partner_55_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_55_Gene_Name:
CAV1

# Macromolecular_Interacting_Partner_55_Protein_Sequence:
>Caveolin1
MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADELSEKQVYDAHTKEIDLVNRDPKHLN
DDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFA
ILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTVCDPLFEAVGKIFSNVRINLQKEI

# Macromolecular_Interacting_Partner_55_Number_of_Residues:
178

# Macromolecular_Interacting_Partner_55_Molecular_Weight:
20472

# Macromolecular_Interacting_Partner_55_Theoretical_pI:
5.93

# Macromolecular_Interacting_Partner_55_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane
Component:  plasma membrane
Component:  caveola
Component:  caveolar membrane

# Macromolecular_Interacting_Partner_55_General_Function:
Not Available

# Macromolecular_Interacting_Partner_55_Specific_Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity

# Macromolecular_Interacting_Partner_55_Pathway:
Not Available

# Macromolecular_Interacting_Partner_55_Reaction:
Not Available

# Macromolecular_Interacting_Partner_55_Pfam_Domain_Function:
PF01146:Caveolin

# Macromolecular_Interacting_Partner_55_Signals:
None

# Macromolecular_Interacting_Partner_55_Transmembrane_Regions:
105-125

# Macromolecular_Interacting_Partner_55_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_55_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_55_GenBank_ID_Protein:
38516

# Macromolecular_Interacting_Partner_55_SwissProt_ID:
CAV1_HUMAN (Q03135)

# Macromolecular_Interacting_Partner_55_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_55_Genecard_id:
CAV1

# Macromolecular_Interacting_Partner_55_Geneatlas_id:
CAV1

# Macromolecular_Interacting_Partner_55_hgnc_id:
HGNC:1527

# Macromolecular_Interacting_Partner_55_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_55_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_55_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_55_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; peripheral membrane protein; cytoplasmic side. Cell membrane; caveola; peripheral membrane protein; cytoplasmic side. Note=Membrane protein of caveolae. Potential hairpin-like structure in the membrane

# Macromolecular_Interacting_Partner_55_Gene_Sequence:
>537 bp
ATGTCTGGGGGCAAATACGTAGACTCGGAGGGACATCTCTACACCGTTCCCATCCGGGAA
CAGGGCAACATCTACAAGCCCAACAACAAGGCCATGGCAGACGAGCTGAGCGAGAAGCAA
GTGTACGACGCGCACACCAAGGAGATCGACCTGGTCAACCGCGACCCTAAACACCTCAAC
GATGACGTGGTCAAGATTGACTTTGAAGATGTGATTGCAGAACCAGAAGGGACACACAGT
TTTCACGGCATTTGGAAGGCCAGCTTCACCACCTTCACTGTGACGAAATACTGGTTTTAC
CGCTTGCTGTCTGCCCTCTTTGGCATCCCGATGGCACTCATCTGGGGCATTTACTTCGCC
ATTCTCTCTTTCCTGCACATCTGGGCAGTTGTACCATGCATTAAGAGCTTCCTGATTGAG
ATTCAGTGCACCAGCCGTGTCTATTCCATCTACGTCCACACCGTCTGTGACCCACTCTTT
GAAGCTGTTGGGAAAATATTCAGCAATGTCCGCATCAACTTGCAGAAAGAAATATAA

# Macromolecular_Interacting_Partner_55_GenBank_ID_Gene:
Z18951

# Macromolecular_Interacting_Partner_55_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_55_Locus:
7q31.1

# Macromolecular_Interacting_Partner_55_SNPs:
rs33972549; rs35242077; rs1049337; rs1049314; rs1049334; rs8713; rs35617054; rs6867; rs34397467; rs35386406; rs34709923; rs9920; rs34585220; rs35273517; rs34123906; rs729949; rs1543293; rs1022436; rs6466587; rs9886215; rs2109516; rs4730751; rs3757732; rs3807994; rs3807992; rs10256914; rs7789117; rs3757733; rs6466583; rs3807995; rs6466586; rs1997572; rs9885998; rs3779512; rs3801995; rs3807988; rs926198; rs959173; rs3807987; rs7804372; rs3807990; rs6466585; rs917664; rs10240619; rs6466584; rs3801993; rs1997623; rs4730748; rs3815412; rs3807986; rs12672038; rs10270569; rs2742125; rs12668226; rs2052105; rs9886219; rs11773845; rs3807989; rs9649394; rs1474510; rs6466588; rs3801994; rs9886216; rs7791631; rs10246396; rs10953822; rs4730749; rs34592877; rs17588703; rs4730750; rs1997571; rs13233553; rs6961881; rs1476833; rs11973363; rs11979788; rs7778733; rs3779514; rs35697540; rs17160353; rs6977359; rs976739; rs11978747; rs35182456; rs12540549; rs12669209; rs926199; rs926200; rs3779513; rs6955882; rs2215448; rs35103261; rs6466582; rs34915824; rs2215449; rs6466581; rs4320488; rs34552012; rs35308471; rs1049375; rs35901258; rs41309216; rs6957212; rs11553391; rs36068092; rs11553390; rs11553395; rs10237996; rs6868; rs7789052; rs11977814; rs6961876; rs34287272; rs2742128; rs35631004; rs36175575; rs3807984; rs3839825; rs35534382; rs11980788; rs11973393; rs35902398; rs3807991; rs10525629; rs35056305; rs34685461; rs28428476; rs5886830; rs34678019; rs34534891; rs36050167; rs13245706; rs35771918; rs2302388; rs2742127; rs13245397; rs13243017; rs34654199; rs35409784; rs33913297; rs13232830; rs34680426; rs11423839; rs35527092; rs6961694; rs6961021; rs13307784; rs6961879; rs28640050; rs2535214; rs35801452; rs13232825; rs3807993; rs35047973; rs34806326; rs34066083; rs4727834; rs13245413; rs34974250; rs13245689; rs10280584; rs6943876; rs1474511; rs2742126; rs10241283; rs34938433; rs10248474; rs35646544; rs3807985; rs10262090; rs11292498; rs10672081; rs35532793; rs10267338; rs34163793; rs976740; rs13242816; rs34400890; rs34773204; rs35141724; rs35500345; rs6975442; rs7458849; rs10570289; rs35467920; rs2535213; rs34587231; rs6950593; rs5886828; rs36224419; rs36224420; rs4385407; rs10570290; rs10227696; rs10232369; rs10250683; rs10257125; rs10258188; rs10273326; rs10280730; rs11974088; rs11979486; rs12540035; rs13224179; rs17138812; rs1860588; rs2052106; rs2109514; rs2109515; rs2159581; rs2535210; rs2535211; rs2535212; rs34936262; rs4236601; rs4730745; rs6959106; rs6961388; rs6976011; rs7795510; rs7802124; rs7802438; rs975028; rs9918538

# Macromolecular_Interacting_Partner_55_General_References:
1360410; 10086342; 10218480; 12368209

# Macromolecular_Interacting_Partner_55_References:
16618703

# Macromolecular_Interacting_Partner_56_ID:
8452

# Macromolecular_Interacting_Partner_56_Name:
Lymphotoxin-beta

# Macromolecular_Interacting_Partner_56_Synonyms:
LT-beta; Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3

# Macromolecular_Interacting_Partner_56_Gene_Name:
LTB

# Macromolecular_Interacting_Partner_56_Protein_Sequence:
>Lymphotoxinbeta
MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD
PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS
DAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLE
GAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGA
VMVG

# Macromolecular_Interacting_Partner_56_Number_of_Residues:
244

# Macromolecular_Interacting_Partner_56_Molecular_Weight:
25390

# Macromolecular_Interacting_Partner_56_Theoretical_pI:
5.02

# Macromolecular_Interacting_Partner_56_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_56_General_Function:
Not Available

# Macromolecular_Interacting_Partner_56_Specific_Function:
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional

# Macromolecular_Interacting_Partner_56_Pathway:
Not Available

# Macromolecular_Interacting_Partner_56_Reaction:
Not Available

# Macromolecular_Interacting_Partner_56_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_56_Signals:
1-35

# Macromolecular_Interacting_Partner_56_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_56_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_56_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_56_GenBank_ID_Protein:
292279

# Macromolecular_Interacting_Partner_56_SwissProt_ID:
TNFC_HUMAN (Q06643)

# Macromolecular_Interacting_Partner_56_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_56_Genecard_id:
LTB

# Macromolecular_Interacting_Partner_56_Geneatlas_id:
LTB

# Macromolecular_Interacting_Partner_56_hgnc_id:
HGNC:6711

# Macromolecular_Interacting_Partner_56_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_56_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_56_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_56_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_56_Gene_Sequence:
>735 bp
ATGGGGGCACTGGGGCTGGAGGGCAGGGGTGGGAGGCTCCAGGGGAGGGGTTCCCTCCTG
CTAGCTGTGGCAGGAGCCACTTCTCTGGTGACCTTGTTGCTGGCGGTGCCTATCACTGTC
CTGGCTGTGCTGGCCTTAGTGCCCCAGGATCAGGGAGGACTGGTAACGGAGACGGCCGAC
CCCGGGGCACAGGCCCAGCAAGGACTGGGGTTTCAGAAGCTGCCAGAGGAGGAGCCAGAA
ACAGATCTCAGCCCCGGGCTCCCAGCTGCCCACCTCATAGGCGCTCCGCTGAAGGGGCAG
GGGCTAGGCTGGGAGACGACGAAGGAACAGGCGTTTCTGACGAGCGGGACGCAGTTCTCG
GACGCCGAGGGGCTGGCGCTCCCGCAGGACGGCCTCTATTACCTCTACTGTCTCGTCGGC
TACCGGGGCCGGGCGCCCCCTGGCGGCGGGGACCCCCAGGGCCGCTCGGTCACGCTGCGC
AGCTCTCTGTACCGGGCGGGGGGCGCCTACGGGCCGGGCACTCCCGAGCTGCTGCTCGAG
GGCGCCGAGACGGTGACTCCAGTGCTGGACCCGGCCAGGAGACAAGGGTACGGGCCTCTC
TGGTACACGAGCGTGGGGTTCGGCGGCCTGGTGCAGCTCCGGAGGGGCGAGAGGGTGTAC
GTCAACATCAGTCACCCCGATATGGTGGACTTCGCGAGAGGGAAGACCTTCTTTGGGGCC
GTGATGGTGGGGTGA

# Macromolecular_Interacting_Partner_56_GenBank_ID_Gene:
L11016

# Macromolecular_Interacting_Partner_56_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_56_Locus:
6p21.3

# Macromolecular_Interacting_Partner_56_SNPs:
Not Available

# Macromolecular_Interacting_Partner_56_General_References:
7916655; 9299492; 10202016

# Macromolecular_Interacting_Partner_56_References:
16699502; 16807266; 17026837; 17070667

# Macromolecular_Interacting_Partner_57_ID:
8461

# Macromolecular_Interacting_Partner_57_Name:
Steroidogenic factor 1

# Macromolecular_Interacting_Partner_57_Synonyms:
STF-1; SF-1; Adrenal 4-binding protein; Steroid hormone receptor Ad4BP; Fushi tarazu factor homolog 1

# Macromolecular_Interacting_Partner_57_Gene_Name:
NR5A1

# Macromolecular_Interacting_Partner_57_Protein_Sequence:
>Steroidogenic factor 1
MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKT
QRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKL
ETGPPMGVPPPPPPAPDYVLPPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVPGAHGPL
AGYLYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPFSGGPNVPELILQLLQLEPDEDQV
RARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQN
CWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLA
LQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLL
LCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT

# Macromolecular_Interacting_Partner_57_Number_of_Residues:
461

# Macromolecular_Interacting_Partner_57_Molecular_Weight:
51637

# Macromolecular_Interacting_Partner_57_Theoretical_pI:
7.73

# Macromolecular_Interacting_Partner_57_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_57_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_57_Specific_Function:
Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1/FTZF1. The SFPQ-NONO- NR5A1/SF-1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3

# Macromolecular_Interacting_Partner_57_Pathway:
Not Available

# Macromolecular_Interacting_Partner_57_Reaction:
Not Available

# Macromolecular_Interacting_Partner_57_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_57_Signals:
None

# Macromolecular_Interacting_Partner_57_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_57_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_57_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_57_GenBank_ID_Protein:
2052388

# Macromolecular_Interacting_Partner_57_SwissProt_ID:
STF1_HUMAN (Q13285)

# Macromolecular_Interacting_Partner_57_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_57_Genecard_id:
NR5A1

# Macromolecular_Interacting_Partner_57_Geneatlas_id:
NR5A1

# Macromolecular_Interacting_Partner_57_hgnc_id:
HGNC:7983

# Macromolecular_Interacting_Partner_57_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_57_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_57_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_57_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_57_Gene_Sequence:
>1386 bp
ATGGACTATTCGTACGACGAGGACCTGGACGAGCTGTGCCCCGTGTGCGGGGACAAGGTG
TCCGGCTACCACTACGGACTGCTCACGTGTGAGAGCTGCAAGGGCTTCTTCAAGCGCACG
GTGCAGAACAACAAGCACTACACGTGCACCGAGAGCCAGAGCTGCAAGATCGACAAGACG
CAGCGCAAGCGCTGTCCCTTCTGCCGCTTCCAGAAATGCCTGACGGTGGGGATGCGCCTG
GAAGCCGTGCGCGCTGACCGTATGAGGGGTGGCCGGAACAAGTTTGGGCCGATGTACAAG
CGGGACCGGGCCCTGAAACAGCAGAAGAAGGCACAGATTCGGGCCAATGGCTTCAAGCTG
GAGACAGGGCCCCCGATGGGGGTGCCCCCGCCGCCCCCTCCCGCACCGGACTACGTGCTG
CCTCCCAGCCTGCATGGGCCTGAGCCCAAGGGCCTGGCCGCCGGTCCACCTGCTGGGCCA
CTGGGCGACTTTGGGGCCCCAGCACTGCCCATGGCCGTGCCCGGTGCCCACGGGCCACTG
GCTGGCTACCTCTACCCTGCCTTTCCTGGCCGTGCCATCAAGTCTGAGTACCCGGAGCCT
TATGCCAGCCCCCCACAGCCTGGGCTGCCGTACGGCTACCCAGAGCCCTTCTCTGGAGGC
CCCAACGTGCCTGAGCTCATCCTGCAGCTGCTGCAGCTGGAGCCGGATGAGGACCAGGTG
CGGGCCCGCATCTTGGGCTGCCTGCAGGAGCCCACCAAAAGCCGCCCCGACCAGCCGGCG
GCCTTCGGCCTCCTGTGCAGAATGGCCGACCAGACCTTCATCTCCATCGTGGACTGGGCA
CGCAGGTGCATGGTCTTCAAGGAGCTGGAGGTGGCCGACCAGATGACGCTGCTGCAGAAC
TGCTGGAGCGAGCTGCTGGTGTTCGACCACATCTACCGCCAGGTCCAGCACGGCAAGGAG
GGCAGCATCCTGCTGGTCACCGGGCAGGAGGTGGAGCTGACCACAGTGGCCACCCAGGCG
GGCTCGCTGCTGCACAGCCTGGTGTTGCGGGCGCAGGAGCTGGTGCTGCAGCTGCTTGCG
CTGCAGCTGGACCGGCAGGAGTTTGTCTGCCTCAAGTTCATCATCCTCTTCAGCCTGGAT
TTGAAGTTCCTGAATAACCACATCCTGGTGAAAGACGCTCAGGAGAAGGCCAACGCCGCC
CTGCTTGACTACACCCTGTGCCACTACCCGCACTGCGGGGACAAATTCCAGCAGCTGCTG
CTGTGCCTGGTGGAGGTGCGGGCCCTGAGCATGCAGGCCAAGGAGTACCTGTACCACAAG
CACCTGGGCAACGAGATGCCCCGCAACAACCTGCTCATCGAAATGCTGCAAGCCAAGCAG
ACTTGA

# Macromolecular_Interacting_Partner_57_GenBank_ID_Gene:
U76388

# Macromolecular_Interacting_Partner_57_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_57_Locus:
9q33

# Macromolecular_Interacting_Partner_57_SNPs:
rs1110061; rs1110062; rs915034; rs3814134; rs12685057; rs10120967; rs12346284; rs10283445; rs3758205; rs1889311; rs7851737; rs6478666; rs873459; rs928548; rs10114542; rs7028021; rs7037254; rs7851142; rs4838189; rs3758204; rs915032; rs7865700; rs7847540; rs2297605; rs4838191; rs2416933; rs7869829; rs915033; rs4838190; rs7869366; rs7043551; rs10818978; rs7855247; rs7866595; rs7869042; rs928547; rs4838192; rs7850767; rs7855380; rs4838187; rs34492804; rs34413492; rs35732712; rs35536919; rs5900617; rs11792231; rs11344948; rs7875999; rs35022630; rs35584614; rs34407097; rs34779907; rs34433451; rs28645246; rs7850743; rs5900619; rs10986356; rs5900618; rs4838188; rs35319224; rs34261941; rs10986355; rs35005839; rs7023736; rs35932294; rs34389184; rs10733670; rs7856059; rs34980472; rs10986354; rs10667987; rs7868306; rs35311356; rs34283574; rs5900620; rs7873345; rs13439968; rs35436654; rs34284067; rs34919731; rs3050280; rs7853506; rs7869797; rs34193774; rs10115552; rs10123508; rs12002499; rs12164290; rs12338118; rs12349577; rs13290767; rs1570581; rs16927495; rs35929043; rs4543647; rs4838186; rs7020027; rs7852843; rs7855918; rs7869318; rs7872472; rs913599; rs9785212

# Macromolecular_Interacting_Partner_57_General_References:
8806624; 11897684; 10369247; 11038323; 11932325

# Macromolecular_Interacting_Partner_57_References:
16782377; 16895991; 17121866

# Macromolecular_Interacting_Partner_58_ID:
8202

# Macromolecular_Interacting_Partner_58_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_58_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_58_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_58_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_58_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_58_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_58_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_58_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_58_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_58_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_58_Pathway:
Not Available

# Macromolecular_Interacting_Partner_58_Reaction:
Not Available

# Macromolecular_Interacting_Partner_58_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_58_Signals:
None

# Macromolecular_Interacting_Partner_58_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_58_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_58_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_58_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_58_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_58_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_58_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_58_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_58_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_58_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_58_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_58_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_58_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_58_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_58_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_58_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_58_Locus:
10q22

# Macromolecular_Interacting_Partner_58_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_58_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_58_References:
16959941; 17028262

# Macromolecular_Interacting_Partner_59_ID:
7991

# Macromolecular_Interacting_Partner_59_Name:
Myocyte-specific enhancer factor 2D

# Macromolecular_Interacting_Partner_59_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_59_Gene_Name:
MEF2D

# Macromolecular_Interacting_Partner_59_Protein_Sequence:
>Myocytespecific enhancer factor 2
DMGRKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNHSNKLFQYAS
TDMDKVLLKYTEYNEPHESRTNADIIETLRKKGFNGCDSPEPDGEDSLEQSPLLEDKYRR
ASEELDGLFRRYGSTVPAPNFAMPVTVPVSNQSSLQFSNPSGSLVTPSLVTSSLTDPRLL
SPQQPALQRNSVSPGLPQRPASAGAMLGGDLNSANGACPSPVGNGYVSARASPGLLPVAN
GNSLNKVIPAKSPPPPTHSTQLGAPSRKPDLRVITSQAGKGLMHHLTEDHLDLNNAQRLG
VSQSTHSLTTPVVSVATPSLLSQGLPFSSMPTAYNTDYQLTSAELSSLPAFSSPGGLSLG
NVTAWQQPQQPQQPQQPQPPQQQPPQPQQPQPQQPQQPQQPPQQQSHLVPVSLSNLIPGS
PLPHVGAALTVTTHPHISIKSEPVSPSRERSPAPPPPAVFPAARPEPGDGLSSPAGGSYE
TGDRDDGRGDFGPTLGLLRPAPEPEAEGSAVKRMRLDTWTLK

# Macromolecular_Interacting_Partner_59_Number_of_Residues:
521

# Macromolecular_Interacting_Partner_59_Molecular_Weight:
55938

# Macromolecular_Interacting_Partner_59_Theoretical_pI:
8.02

# Macromolecular_Interacting_Partner_59_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_59_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_59_Specific_Function:
Transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription

# Macromolecular_Interacting_Partner_59_Pathway:
Not Available

# Macromolecular_Interacting_Partner_59_Reaction:
Not Available

# Macromolecular_Interacting_Partner_59_Pfam_Domain_Function:
PF00319:SRF-TF

# Macromolecular_Interacting_Partner_59_Signals:
None

# Macromolecular_Interacting_Partner_59_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_59_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_59_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_59_GenBank_ID_Protein:
401769

# Macromolecular_Interacting_Partner_59_SwissProt_ID:
MEF2D_HUMAN (Q14814)

# Macromolecular_Interacting_Partner_59_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_59_Genecard_id:
MEF2D

# Macromolecular_Interacting_Partner_59_Geneatlas_id:
MEF2D

# Macromolecular_Interacting_Partner_59_hgnc_id:
HGNC:6997

# Macromolecular_Interacting_Partner_59_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_59_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_59_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_59_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_59_Gene_Sequence:
>1566 bp
ATGGGGAGGAAAAAGATTCAGATCCAGCGAATCACCGACGAGCGGAACCGACAGGTGACT
TTCACCAAGCGGAAGTTTGGCCTGATGAAGAAGGCGTATGAGCTGAGCGTGCTATGTGAC
TGCGAGATCGCACTCATCATCTTCAACCACTCCAACAAGCTGTTCCAGTACGCCAGCACC
GACATGGACAAGGTGCTGCTCAAGTACACGGAGTACAATGAGCCACACGAGAGCCGCACC
AACGCCGACATCATCGAGACCCTGAGGAAGAAGGGCTTCAATGGCTGCGACAGCCCCGAG
CCCGACGGGGAGGACTCGCTGGAACAGAGCCCCCTGCTGGAGGACAAGTACCGACGCGCC
AGCGAGGAGCTCGACGGGCTCTTCCGGCGCTATGGGTCAACTGTCCCGGCCCCCAACTTT
GCCATGCCTGTCACGGTGCCCGTGTCCAATCAGAGCTCACTGCAGTTCAGCAATCCCAGC
GGCTCCCTGGTCACCCCTTCCCTGGTGACATCATCCCTCACGGACCCGCGGCTCCTGTCC
CCCCAGCAGCCAGCACTACAGAGGAACAGTGTGTCTCCTGGCCTGCCCCAGCGGCCAGCT
AGTGCGGGGGCCATGCTGGGGGGTGACCTGAACAGTGCTAACGGAGCCTGCCCCAGCCCT
GTTGGGAATGGCTACGTCAGTGCTCGGGCTTCCCCTGGCCTCCTCCCTGTGGCCAATGGC
AACAGCCTAAACAAGGTCATCCCTGCCAAGTCTCCGCCCCCACCTACCCACAGCACCCAG
CTTGGAGCCCCCAGCCGCAAGCCCGACCTGCGAGTCATCACTTCCCAGGCAGGAAAGGGG
TTAATGCATCACTTGACTGAGGACCATTTAGATCTGAACAATGCCCAGCGCCTTGGGGTC
TCCCAGTCTACTCATTCGCTCACCACCCCAGTGGTTTCTGTGGCAACGCCGAGTTTACTC
AGCCAGGGCCTCCCCTTCTCTTCCATGCCCACTGCCTACAACACAGATTACCAGTTGACC
AGTGCAGAGCTCTCCTCCTTACCAGCCTTTAGTTCACCTGGGGGGCTGTCGCTAGGCAAT
GTCACTGCCTGGCAACAGCCACAGCAGCCCCAGCAGCCGCAGCAGCCACAGCCTCCACAG
CAGCAGCCACCGCAGCCACAGCAGCCACAGCCACAGCAGCCTCAGCAGCCGCAACAGCCA
CCTCAGCAACAGTCCCACCTGGTCCCTGTATCTCTCAGCAACCTCATCCCGGGCAGCCCC
CTGCCCCACGTGGGTGCTGCCCTCACAGTCACCACCCACCCCCACATCAGCATCAAGTCA
GAACCGGTGTCCCCAAGCCGTGAGCGCAGCCCTGCGCCTCCCCCTCCAGCTGTGTTCCCA
GCTGCCCGCCCTGAGCCTGGCGATGGTCTCAGCAGCCCAGCCGGGGGATCCTATGAGACG
GGAGACCGGGATGACGGACGGGGGGACTTCGGGCCCACACTGGGCCTGCTGCGCCCAGCC
CCAGAGCCTGAGGCTGAGGGCTCAGCTGTGAAGAGGATGCGGCTTGATACCTGGACATTA
AAGTGA

# Macromolecular_Interacting_Partner_59_GenBank_ID_Gene:
L16794

# Macromolecular_Interacting_Partner_59_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_59_Locus:
1q12-q23

# Macromolecular_Interacting_Partner_59_SNPs:
rs1925950; rs1185700; rs2274317; rs3790459; rs11264486; rs1171561; rs3790460; rs746527; rs1171563; rs3790455; rs3790458; rs1342442; rs10908505; rs1050316; rs3790457; rs2274320; rs1750305; rs11576224; rs3818463; rs16837427; rs12038396; rs1171560; rs1925951; rs3790461; rs947660; rs10908504; rs1750304; rs2274319; rs2282286; rs12131289; rs1171557; rs3790454; rs1109751; rs2274316; rs1171558; rs6700679; rs4453029; rs6697250; rs4450010; rs1171559; rs6663537; rs16837415; rs2274318; rs6658120; rs1171551; rs10796959; rs3762279; rs1171550; rs1171549; rs12568861; rs2274315; rs34630845; rs41267363; rs3748566; rs34248774; rs34924929; rs11577981; rs5777987; rs3790456; rs41267367; rs7538905; rs36023544; rs35637146; rs36035076; rs34471593; rs10622498; rs10643556; rs28373128; rs35769575; rs36118495; rs28730744; rs41267365; rs34888645; rs34523635; rs28593044; rs1171562; rs11558893; rs35592793; rs9970660; rs28396179; rs16837417; rs12121397; rs28730742; rs6698405; rs4661042; rs35005762; rs28730743; rs6669167; rs1778835; rs12130411; rs36034290; rs2003401; rs3790452; rs28730741; rs7415630; rs6666307; rs28730739; rs12074233; rs4661043; rs35251582; rs28730740; rs4614250; rs12739072; rs12728546; rs3748565; rs12739068; rs12073250; rs1171548; rs10159180; rs11264488; rs1171552; rs1171553; rs1171554; rs1171556; rs12136856; rs12759941; rs16837408; rs1774953; rs4542206; rs750439

# Macromolecular_Interacting_Partner_59_General_References:
8269842; 10523670

# Macromolecular_Interacting_Partner_59_References:
16870618

# Macromolecular_Interacting_Partner_60_ID:
7871

# Macromolecular_Interacting_Partner_60_Name:
Neuropeptide S receptor

# Macromolecular_Interacting_Partner_60_Synonyms:
G-protein coupled receptor 154; G-protein coupled receptor for asthma susceptibility; G-protein coupled receptor PGR14

# Macromolecular_Interacting_Partner_60_Gene_Name:
NPSR1

# Macromolecular_Interacting_Partner_60_Protein_Sequence:
>Neuropeptide S receptor
MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLF
VFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLV
CRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIP
TLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIK
SKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFN
LLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERH
EMQILSKPEFI

# Macromolecular_Interacting_Partner_60_Number_of_Residues:
371

# Macromolecular_Interacting_Partner_60_Molecular_Weight:
42687

# Macromolecular_Interacting_Partner_60_Theoretical_pI:
8.44

# Macromolecular_Interacting_Partner_60_GO_Classification:
>>>
Function:  peptide receptor activity, G-protein coupled
Function:  vasopressin-like receptor activity
Function:  vasopressin receptor activity
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_60_General_Function:
Not Available

# Macromolecular_Interacting_Partner_60_Specific_Function:
May be active in signaling pathway in an autocrine or paracrine fashion in several tissues. Receptor for neuropeptide S, it may mediate its action, such as inhibitory effects, on cell growth. Involved in pathogenesis of asthma and other IgE-mediated diseases

# Macromolecular_Interacting_Partner_60_Pathway:
Not Available

# Macromolecular_Interacting_Partner_60_Reaction:
Not Available

# Macromolecular_Interacting_Partner_60_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_60_Signals:
None

# Macromolecular_Interacting_Partner_60_Transmembrane_Regions:
53-73
83-103
124-144
165-185
213-233
276-296
313-333

# Macromolecular_Interacting_Partner_60_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_60_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_60_GenBank_ID_Protein:
34596864

# Macromolecular_Interacting_Partner_60_SwissProt_ID:
NPSR1_HUMAN (Q6W5P4)

# Macromolecular_Interacting_Partner_60_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_60_Genecard_id:
NPSR1

# Macromolecular_Interacting_Partner_60_Geneatlas_id:
NPSR1

# Macromolecular_Interacting_Partner_60_hgnc_id:
HGNC:23631

# Macromolecular_Interacting_Partner_60_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_60_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_60_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_60_Subcellular_Location:
Isoform 1:Cell membrane; multi-pass membrane protein. Isoform 3:Cell membrane; multi-pass membrane protein. Isoform 4:Cell membrane; multi-pass membrane protein. Isoform 2:Cytoplasm. Isoform 5:Cytoplasm. Isoform 6:Cytoplasm. Isoform 7:Cytoplasm. Isoform 9:Cytoplasm

# Macromolecular_Interacting_Partner_60_Gene_Sequence:
>1116 bp
ATGCCAGCCAACTTCACAGAGGGCAGCTTCGATTCCAGTGGGACCGGGCAGACGCTGGAT
TCTTCCCCAGTGGCTTGCACTGAAACAGTGACTTTTACTGAAGTGGTGGAAGGAAAGGAA
TGGGGTTCCTTCTACTACTCCTTTAAGACTGAGCAATTGATAACTCTGTGGGTCCTCTTT
GTTTTTACCATTGTTGGAAACTCCGTTGTGCTTTTTTCCACATGGAGGAGAAAGAAGAAG
TCAAGAATGACCTTCTTTGTGACTCAGCTGGCCATCACAGATTCTTTCACAGGACTGGTC
AACATCTTGACAGATATTAATTGGCGATTCACTGGAGACTTCACGGCACCTGACCTGGTT
TGCCGAGTGGTCCGCTATTTGCAGGTTGTGCTGCTCTACGCCTCTACCTACGTCCTGGTG
TCCCTCAGCATAGACAGATACCATGCCATCGTCTACCCCATGAAGTTCCTTCAAGGAGAA
AAGCAAGCCAGGGTCCTCATTGTGATCGCCTGGAGCCTGTCTTTTCTGTTCTCCATTCCC
ACCCTGATCATATTTGGGAAGAGGACACTGTCCAACGGTGAAGTGCAGTGCTGGGCCCTG
TGGCCTGACGACTCCTACTGGACCCCATACATGACCATCGTGGCCTTCCTGGTGTACTTC
ATCCCTCTGACAATCATCAGCATCATGTATGGCATTGTGATCCGAACTATTTGGATTAAA
AGCAAAACCTACGAAACAGTGATTTCCAACTGCTCAGATGGGAAACTGTGCAGCAGCTAT
AACCGAGGACTCATCTCAAAGGCAAAAATCAAGGCTATCAAGTATAGCATCATCATCATT
CTTGCCTTCATCTGCTGTTGGAGTCCATACTTCCTGTTTGACATTTTGGACAATTTCAAC
CTCCTTCCAGACACCCAGGAGCGTTTCTATGCCTCTGTGATCATTCAGAACCTGCCAGCA
TTGAATAGTGCCATCAACCCCCTCATCTACTGTGTCTTCAGCAGCTCCATCTCTTTCCCC
TGCAGGGAGCAAAGATCACAGGATTCCAGAATGACGTTCCGGGAGAGAACTGAGAGGCAT
GAGATGCAGATTCTGTCCAAGCCAGAATTCATCTAG

# Macromolecular_Interacting_Partner_60_GenBank_ID_Gene:
AY310326

# Macromolecular_Interacting_Partner_60_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_60_Locus:
7p14.3

# Macromolecular_Interacting_Partner_60_SNPs:
rs7809642; rs10243897; rs7805675; rs12701391; rs11979944; rs13229970; rs6978087; rs11769430; rs11769407; rs13310747; rs13310840; rs13230135; rs28480169; rs13307415; rs13227114; rs13438159; rs13243083; rs13307507; rs13307244; rs13235984; rs13227229; rs13222976; rs28699135; rs13243490; rs2097858; rs12701392; rs5883476; rs34903149; rs13243621; rs2392287; rs28576287; rs13307778; rs34157915; rs13310444; rs35295382; rs4000112; rs1894745; rs4087728; rs2392286; rs13243494; rs10268842; rs13328346; rs6958041; rs7811879; rs13310855; rs1894746; rs13243373; rs12701390; rs2893487; rs13307570; rs36066201; rs28590377; rs1006392; rs1006393; rs1006394; rs10081183; rs10081224; rs1013126; rs10215263; rs10215901; rs10215941; rs10225627; rs10225759; rs10226373; rs10230162; rs10230379; rs10230513; rs10232363; rs10233723; rs1023555; rs1023556; rs10235636; rs10235648; rs10238983; rs10239860; rs10240711; rs10240801; rs10241507; rs10241616; rs10241737; rs10241772; rs10242970; rs10243634; rs10243849; rs10244389; rs10244603; rs10245014; rs10245329; rs10246825; rs10249085; rs10249271; rs10249606; rs10249614; rs10250336; rs10250709; rs10251302; rs10251716; rs10253137; rs10253465; rs10255950; rs10255979; rs10255999; rs10256489; rs10257063; rs10257646; rs10258734; rs10259175; rs10259788; rs10261743; rs10263313; rs10263447; rs10265037; rs10265775; rs10267134; rs10267935; rs10269284; rs10269806; rs10269833; rs10270663; rs10270766; rs10271262; rs10271686; rs10273903; rs10274146; rs10275028; rs10275644; rs10276528; rs10278663; rs10279907; rs10280995; rs10282306; rs10486653; rs10486655; rs10486656; rs10486657; rs10951425; rs10951426; rs11486758; rs11761093; rs11761197; rs11761288; rs11762538; rs11762584; rs11762763; rs11763481; rs11764535; rs11765573; rs11767110; rs11768189; rs11770143; rs11770325; rs11770777; rs11771396; rs11771425; rs11771697; rs11773493; rs11970820; rs11972817; rs11973406; rs11974932; rs11975122; rs11976769; rs11978538; rs11979661; rs11979833; rs11980520; rs11981253; rs11982905; rs11983674; rs12111597; rs12154551; rs12530657; rs12532883; rs12534336; rs12534369; rs12670834; rs12672298; rs12673132; rs12701383; rs12701388; rs13222249; rs13226161; rs13226168; rs13226345; rs13231222; rs13231258; rs13235228; rs13238088; rs13240651; rs13245684; rs13246028; rs13246143; rs13309682; rs13340537; rs1345267; rs1345270; rs1362176; rs1362177; rs1362193; rs1379923; rs1379924; rs1379925; rs1379927; rs1379928; rs1419779; rs1419780; rs1419789; rs1419790; rs1419791; rs1419792; rs1419793; rs1419794; rs1419795; rs1419796; rs1419797; rs1419835; rs1419836; rs1419837; rs1419867; rs1419868; rs1458532; rs1458533; rs1458534; rs1458535; rs1458536; rs1458537; rs1458538; rs1458539; rs1458541; rs1458543; rs1458544; rs1458545; rs1458546; rs1458547; rs1458548; rs1458550; rs1563687; rs1585255; rs1592418; rs1592423; rs1592441; rs17150824; rs17169964; rs17169985; rs17169992; rs17169993; rs17169994; rs17169995; rs17170001; rs17170011; rs17170012; rs17170013; rs17170015; rs17170017; rs17170021; rs17189135; rs17189268; rs17197425; rs17197589; rs17197848; rs17197911; rs17198065; rs17198093; rs17198163; rs17198254; rs17198624; rs17198982; rs17199395; rs17199458; rs17199659; rs17199818; rs17199853; rs17199888; rs17200135; rs17200455; rs172868; rs17776082; rs17776235; rs17776257; rs17776930; rs17777040; rs17777441; rs17777663; rs17777675; rs17788770; rs17788843; rs17789096; rs17789287; rs17789420; rs17789432; rs17789456; rs17789480; rs17789624; rs17789642; rs17789834; rs17790181; rs17790961; rs182718; rs184448; rs1860369; rs1860370; rs1963499; rs2021374; rs2022142; rs2023529; rs2023530; rs2109124; rs2125403; rs2125404; rs2125406; rs2168890; rs2168891; rs2168892; rs2215144; rs2215293; rs2392276; rs2392285; rs2529494; rs2530531; rs2530536; rs2530539; rs2530543; rs2530544; rs2530545; rs2530546; rs2530547; rs2530548; rs2530549; rs2530550; rs2530551; rs2530552; rs2530553; rs2530554; rs2530556; rs2530557; rs2530558; rs2530559; rs2530560; rs2530561; rs2530564; rs2530565; rs2530566; rs2530567; rs2530568; rs2530569; rs2530570; rs2530571; rs2530572; rs2531837; rs2531838; rs2531839; rs2531840; rs2609210; rs2609211; rs2609212; rs2609214; rs2609215; rs2609216; rs2609217; rs2609218; rs2609219; rs2609220; rs2609222; rs2609223; rs2609224; rs2609226; rs2609227; rs2609228; rs2609229; rs2609231; rs2609233; rs2609234; rs2609242; rs2609252; rs323907; rs323909; rs323910; rs323911; rs323912; rs323913; rs323914; rs323916; rs323917; rs323918; rs323920; rs323922; rs323925; rs324372; rs324373; rs324374; rs324375; rs324376; rs324377; rs324380; rs324381; rs324383; rs324386; rs324389; rs324392; rs324393; rs324395; rs324397; rs324398; rs324399; rs324956; rs324957; rs324958; rs324959; rs324960; rs324961; rs324962; rs324963; rs324964; rs324965; rs324966; rs324967; rs324968; rs324975; rs324976; rs324977; rs324978; rs324980; rs324981; rs324982; rs324983; rs324984; rs324985; rs324986; rs324987; rs324989; rs325454; rs325456; rs325457; rs325459; rs325462; rs325463; rs325464; rs325465; rs325466; rs325467; rs325468; rs325477; rs33927965; rs33956262; rs34609357; rs34683710; rs34724449; rs35029494; rs35260880; rs35534471; rs35785627; rs35878152; rs35992792; rs376825; rs401256; rs411323; rs411791; rs4141216; rs423282; rs425990; rs4272270; rs438778; rs450463; rs4580944; rs5005133; rs6462579; rs6462580; rs6946103; rs6947323; rs6947841; rs6949087; rs6952485; rs6952922; rs6953479; rs6956356; rs6956463; rs6957501; rs6957774; rs6958905; rs6960864; rs6960952; rs6961859; rs6962757; rs6964821; rs6964828; rs6970989; rs6972158; rs6975521; rs6975546; rs6976985; rs6977332; rs6977729; rs6979428; rs714588; rs725902; rs727162; rs7357323; rs740347; rs740623; rs740717; rs740718; rs740723; rs7457172; rs758399; rs764268; rs764269; rs765023; rs7792476; rs7794853; rs7804942; rs7806620; rs7812206; rs887020; rs898067; rs898068; rs898069; rs898070; rs898071; rs963218; rs963219; rs963220; rs9648043; rs9655357; rs9655359; rs9792042; rs988367; rs9986878

# Macromolecular_Interacting_Partner_60_General_References:
Not Available

# Macromolecular_Interacting_Partner_60_References:
16627466; 16647194; 16924114

# Macromolecular_Interacting_Partner_61_ID:
7838

# Macromolecular_Interacting_Partner_61_Name:
PACAP protein

# Macromolecular_Interacting_Partner_61_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_61_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_61_Protein_Sequence:
>PACAP protein
MVTGGPWPTRLSRTCLHYLGEFGEDQIYEAHQQGRGALEALLCGGPQGACSEKVSATREE
L

# Macromolecular_Interacting_Partner_61_Number_of_Residues:
61

# Macromolecular_Interacting_Partner_61_Molecular_Weight:
6606

# Macromolecular_Interacting_Partner_61_Theoretical_pI:
4.92

# Macromolecular_Interacting_Partner_61_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_61_General_Function:
Not Available

# Macromolecular_Interacting_Partner_61_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_61_Pathway:
Not Available

# Macromolecular_Interacting_Partner_61_Reaction:
Not Available

# Macromolecular_Interacting_Partner_61_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_61_Signals:
None

# Macromolecular_Interacting_Partner_61_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_61_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_61_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_61_GenBank_ID_Protein:
31455257

# Macromolecular_Interacting_Partner_61_SwissProt_ID:
Q7Z6N2_HUMAN (Q7Z6N2)

# Macromolecular_Interacting_Partner_61_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_61_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_61_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_61_hgnc_id:
Not Available

# Macromolecular_Interacting_Partner_61_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_61_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_61_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_61_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_61_Gene_Sequence:
>186 bp
ATGGTCACAGGGGGCCCCTGGCCTACCAGGCTCTCCAGGACATGTTTGCACTACTTGGGG
GAGTTTGGAGAAGACCAGATCTATGAAGCCCACCAACAAGGCCGAGGGGCTCTGGAGGCA
TTGCTATGTGGGGGACCCCAGGGGGCCTGCTCAGAGAAGGTGTCAGCCACAAGAGAAGAG
CTCTAG

# Macromolecular_Interacting_Partner_61_GenBank_ID_Gene:
BC009931

# Macromolecular_Interacting_Partner_61_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_61_Locus:
Not Available

# Macromolecular_Interacting_Partner_61_SNPs:
Not Available

# Macromolecular_Interacting_Partner_61_General_References:
12477932

# Macromolecular_Interacting_Partner_61_References:
16723209; 16928405

# Macromolecular_Interacting_Partner_62_ID:
8453

# Macromolecular_Interacting_Partner_62_Name:
Rap guanine nucleotide exchange factor 4

# Macromolecular_Interacting_Partner_62_Synonyms:
cAMP-regulated guanine nucleotide exchange factor II; cAMP-GEFII; Exchange factor directly activated by cAMP 2; Epac 2

# Macromolecular_Interacting_Partner_62_Gene_Name:
RAPGEF4

# Macromolecular_Interacting_Partner_62_Protein_Sequence:
>Rap guanine nucleotide exchange factor 4
MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY
YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
TPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT
PLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTE
LVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP
TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL
STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD
FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV
PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVF
MPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMA
FLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK
RQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEK
VVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM
TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR
VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM
DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART
VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP

# Macromolecular_Interacting_Partner_62_Number_of_Residues:
1011

# Macromolecular_Interacting_Partner_62_Molecular_Weight:
115523

# Macromolecular_Interacting_Partner_62_Theoretical_pI:
6.83

# Macromolecular_Interacting_Partner_62_GO_Classification:
>>>
Function:  GTPase regulator activity
Function:  small GTPase regulator activity
Function:  guanyl-nucleotide exchange factor activity
Function:  enzyme regulator activity
Function:  kinase regulator activity
Function:  protein kinase regulator activity
Function:  cAMP-dependent protein kinase regulator activity
 ||
>>>
Process:  small GTPase mediated signal transduction
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  protein complex
Component:  unlocalized protein complex
Component:  cAMP-dependent protein kinase complex

# Macromolecular_Interacting_Partner_62_General_Function:
Signal transduction mechanisms 

# Macromolecular_Interacting_Partner_62_Specific_Function:
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2

# Macromolecular_Interacting_Partner_62_Pathway:
Not Available

# Macromolecular_Interacting_Partner_62_Reaction:
Not Available

# Macromolecular_Interacting_Partner_62_Pfam_Domain_Function:
PF00027:cNMP_binding;
PF00610:DEP;
PF00788:RA;
PF00617:RasGEF;
PF00618:RasGEF_N

# Macromolecular_Interacting_Partner_62_Signals:
None

# Macromolecular_Interacting_Partner_62_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_62_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_62_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_62_GenBank_ID_Protein:
4115909

# Macromolecular_Interacting_Partner_62_SwissProt_ID:
RPGF4_HUMAN (Q8WZA2)

# Macromolecular_Interacting_Partner_62_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_62_Genecard_id:
RAPGEF4

# Macromolecular_Interacting_Partner_62_Geneatlas_id:
RAPGEF4

# Macromolecular_Interacting_Partner_62_hgnc_id:
HGNC:16626

# Macromolecular_Interacting_Partner_62_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_62_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_62_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_62_Subcellular_Location:
Cytoplasm. Membrane; peripheral membrane protein

# Macromolecular_Interacting_Partner_62_Gene_Sequence:
>3036 bp
ATGGTCGCTGCGCACGCTGCCCATTCTTCCTCCTCTGCCGAGTGGATCGCCTGCCTGGAT
AAAAGACCACTGGAGCGATCCAGCGAAGATGTGGATATAATCTTCACTCGACTGAAAGAA
GTTAAAGCTTTTGAGAAATTTCACCCAAATCTCCTTCATCAGATTTGCTTATGTGGTTAT
TATGAGAATCTGGAAAAGGGAATAACATTATTTCGCCAGGGTGATATTGGAACAAACTGG
TATGCTGTCCTGGCAGGGTCTTTGGATGTTAAAGTATCTGAGACCAGCAGTCACCAGGAT
GCTGTGACCATCTGTACCCTGGGAATTGGGACGGCCTTTGGAGAGTCCATTCTGGACAAC
ACACCCCGCCATGCAACCATCGTTACCAGGGAGAGCAGTGAACTGCTCCGCATCGAGCAG
AAGGACTTCAAGGCACTATGGGAGAAATATCGACAGTATATGGCAGGACTTCTGGCTCCT
CCTTATGGTGTTATGGAAACGGGCTCTAACAATGACAGGATTCCTGACAAGGAGAACACA
CCTCTCATTGAACCTCACGTTCCTCTTCGTCCTGCTAACACCATTACCAAGGTCCCTTCA
GAGAAGATCCTCAGAGCTGGAAAAATTTTACGAAATGCCATTCTCTCTCGAGCACCTCAC
ATGATAAGAGATAGAAAATACCACCTAAAGACATACAGACAATGCTGTGTGGGAACTGAA
CTGGTGGACTGGATGATGCAGCAGACACCATGTGTTCACTCCCGGACTCAAGCTGTTGGC
ATGTGGCAAGTCCTGTTAGAAGATGGTGTTCTCAACCACGTGGACCAGGAGCACCATTTC
CAAGACAAATATTTATTCTATCGATTTCTGGATGATGAGCACGAGGATGCCCCTTTGCCT
ACTGAGGAGGAGAAGAAGGAGTGTGATGAGGAGCTCCAGGACACCATGCTGCTGCTGTCA
CAGATGGGCCCCGACGCCCACATGAGGATGATCCTTCGCAAACCACCTGGCCAGAGGACT
GTGGATGACCTAGAGATTATCTATGAGGAGCTTCTTCATATTAAAGCCTTATCCCATCTT
TCTACCACAGTGAAACGAGAGTTAGCAGGTGTTCTCATTTTTGAGTCTCACGCCAAAGGA
GGGACTGTGTTGTTTAACCAGGGGGAAGAAGGTACCTCCTGGTACATTATTCTAAAAGGA
TCAGTGAATGTAGTCATTTACGGCAAGGGTGTGGTCTGCACCCTGCATGAAGGAGATGAC
TTCGGCAAGTTAGCACTAGTGAATGATGCCCCACGAGCTGCCTCTATCGTCTTACGAGAA
GATAACTGCCATTTCTTAAGAGTAGACAAGGAGGATTTCAACCGGATCCTAAGGGACGTG
GAGGCGAATACAGTCAGACTTAAAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTC
CCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTG
ATGTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCA
ACTTTAAATGAAGCAACAGATTCTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTT
ATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAA
GGTACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTG
GTTCTACAGTGGGCTGCCATGTATGGAGACCTCCTGCAAGAGGATGACGTATCTATGGCC
TTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAG
GAGCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCA
CAAAAGAAGCACAAGGTTCTTTTGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAG
CGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACC
TACACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCC
GACAAGCTGGGCTCCGGGGAGGGCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAG
GTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTG
TTTGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCA
ACTGTTGGAACAGTGGGAACTTTTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATG
ACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACA
TTTGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTT
AATGAAATTCAGTTTTGGGTCGTCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGT
GTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTG
AATTCCTTTTTTGCCATCGTCATGGGACTAAGTAACATTGCTGTGAGCCGCTTGGCACTA
ACGTGGGAGAAACTGCCAAGCAAGTTCAAGAAGTTCTATGCGGAGTTTGAAAGTTTAATG
GACCCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAACCTCCTCTC
ATCCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACG
TTCATTGACAATCTAGTAAACTTTGAAAAAATGCGCATGATTGCAAATACGGCCAGAACA
GTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCAT
CAGGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCA
CAGATGTCACACAGATTAGAGCCTCGTCGACCATAG

# Macromolecular_Interacting_Partner_62_GenBank_ID_Gene:
U78516

# Macromolecular_Interacting_Partner_62_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_62_Locus:
2q31-q32

# Macromolecular_Interacting_Partner_62_SNPs:
rs35825006; rs34253418; rs17301507; rs7584063; rs16861249; rs2042561; rs2676506; rs1863167; rs2592939; rs729486; rs2044517; rs2884283; rs2553014; rs2592938; rs1863173; rs2042565; rs1979186; rs2592941; rs2553011; rs2042562; rs2676521; rs2592942; rs895583; rs2290374; rs1551248; rs2044516; rs2258918; rs2468391; rs2258180; rs2553008; rs2553001; rs750372; rs1551249; rs2247800; rs2552996; rs2113807; rs2258081; rs1863166; rs2602216; rs2161994; rs745288; rs1344591; rs2258175; rs2592940; rs2468389; rs2676512; rs2194720; rs2242079; rs12473597; rs1446980; rs3769223; rs13410779; rs10930571; rs12693016; rs1991174; rs3769234; rs938668; rs4972858; rs2884346; rs1867942; rs2081406; rs3769313; rs6742219; rs4296399; rs12693013; rs2113806; rs3769222; rs2676505; rs12987382; rs12615974; rs750374; rs13030842; rs12471745; rs4972856; rs3754750; rs1020599; rs12467354; rs11898166; rs6433386; rs2676510; rs13398940; rs3769218; rs7563076; rs3769211; rs3754751; rs2166588; rs3769318; rs3769219; rs13413796; rs4972861; rs750373; rs2676504; rs12053389; rs12620803; rs6760256; rs7573201; rs11682941; rs752729; rs6752140; rs2012213; rs4972862; rs1991173; rs7603772; rs1597649; rs12624093; rs2098822; rs2357950; rs951314; rs4972393; rs10203199; rs1991175; rs2468392; rs7581330; rs3754753; rs12619862; rs10193942; rs10206140; rs951315; rs6734119; rs6755658; rs3769213; rs6433382; rs6715990; rs7606797; rs6717529; rs2602217; rs3769210; rs3769273; rs2676520; rs10188856; rs11885983; rs1344590; rs1026290; rs6433377; rs3769278; rs930624; rs12612612; rs10497389; rs1559626; rs3754749; rs2290375; rs3922225; rs4972518; rs16861161; rs3769295; rs3769309; rs10190070; rs6719635; rs11695769; rs13000260; rs2676502; rs17746510; rs7566445; rs3769237; rs6717489; rs4989336; rs2676509; rs4972519; rs10514632; rs2166590; rs17374295; rs3769289; rs12619395; rs2676525; rs13395872; rs12478288; rs2676511; rs3769231; rs1968290; rs12618968; rs3820840; rs2011562; rs2553003; rs3820852; rs3820838; rs3769306; rs3769265; rs7584737; rs3820839; rs7584826; rs1344593; rs6722709; rs2676523; rs724997; rs17754945; rs4972523; rs11691292; rs10180877; rs16861206; rs6759940; rs3769247; rs12621641; rs2194723; rs3769235; rs10194482; rs2553015; rs10754979; rs4972394; rs4972526; rs12693015; rs6750399; rs3769243; rs6713665; rs717524; rs7595105; rs3820847; rs2357808; rs10514633; rs2194718; rs3769215; rs10497387; rs13026645; rs2553004; rs6433380; rs1446978; rs1451448; rs16860857; rs16860884; rs2552999; rs3769229; rs1863168; rs12616130; rs10490703; rs3754757; rs13007746; rs2676501; rs3754766; rs16861119; rs12619176; rs3769283; rs2290378; rs1863172; rs11884979; rs16860975; rs1986155; rs6754271; rs6713228; rs16861185; rs768030; rs10930573; rs3769252; rs933785; rs12473986; rs1124821; rs12614386; rs2602215; rs16860965; rs2305462; rs3769228; rs12693014; rs1806830; rs4972524; rs6433379; rs6761798; rs11897801; rs3820841; rs3769307; rs16861191; rs3769221; rs1344592; rs7585545; rs12612593; rs6727383; rs1597648; rs2676517; rs3769232; rs6751505; rs12622141; rs3769315; rs2676527; rs2113804; rs13032969; rs13404856; rs2028934; rs3820842; rs4972527; rs7604728; rs13425786; rs12989240; rs1374488; rs6747569; rs1124747; rs12997037; rs1031223; rs2305461; rs2676507; rs13432300; rs7604773; rs3769216; rs3769245; rs16861137; rs6717735; rs10497388; rs2676513; rs12465032; rs2676528; rs11680594; rs2676516; rs12620106; rs3769317; rs2553009; rs3769254; rs6735942; rs11685193; rs3754760; rs3769253; rs2592944; rs16860984; rs2553016; rs13026466; rs6740103; rs3769304; rs2290372; rs1446982; rs3769220; rs3769236; rs2011581; rs3754764; rs718902; rs13411719; rs1446981; rs17300973; rs4972854; rs10206361; rs11695696; rs16861121; rs6433378; rs10174863; rs956752; rs2290376; rs6433388; rs1992808; rs3769312; rs1451450; rs6705576; rs7604579; rs3769292; rs17706770; rs6754857; rs2357806; rs3769250; rs3769266; rs16860905; rs16860895; rs2113808; rs6745299; rs2121483; rs12474304; rs12473599; rs17756739; rs7575405; rs3754754; rs2592945; rs12623346; rs3820843; rs7583076; rs2194715; rs6705188; rs10197498; rs12996130; rs10175694; rs7562214; rs2194716; rs10195939; rs17704332; rs3769227; rs16860879; rs16861187; rs2676515; rs17756703; rs13036004; rs3769281; rs12615893; rs4972525; rs17705626; rs16860958; rs7574315; rs16861026; rs12474017; rs3769246; rs16860845; rs11894771; rs13031540; rs3754763; rs17704976; rs2194721; rs17803021; rs1823151; rs16860945; rs3769258; rs6728765; rs10168444; rs17706463; rs12474338; rs2357807; rs12621472; rs17755455; rs1965694; rs3769280; rs13033705; rs17705390; rs6725226; rs13409596; rs17704392; rs11693099; rs2884281; rs11677165; rs16861062; rs11897409; rs7608816; rs4972521; rs13019093; rs11676171; rs7575310; rs6758260; rs7585729; rs2676499; rs3754762; rs3769276; rs1026289; rs3769287; rs3769268; rs16860911; rs17689935; rs7559002; rs12622441; rs2553000; rs16860904; rs16861148; rs2194717; rs6707251; rs12620826; rs6741842; rs17756405; rs7570254; rs938669; rs10203074; rs11900684; rs6740395; rs11888111; rs2676518; rs1878386; rs7587431; rs16861089; rs3769294; rs16861216; rs6722738; rs10188641; rs17705358; rs7601802; rs13428282; rs3820844; rs13416723; rs2012214; rs2357952; rs10497390; rs16861098; rs17704262; rs3769320; rs7559950; rs17706174; rs2432927; rs10190809; rs3769249; rs16860897; rs3769264; rs6714492; rs17754879; rs7566526; rs10178693; rs7607344; rs2676519; rs2676522; rs7560467; rs2121481; rs2357948; rs16861147; rs12105647; rs17705852; rs17706880; rs3930351; rs2123506; rs6751860; rs17754423; rs1469214; rs1823153; rs2676514; rs16861180; rs2553010; rs16860900; rs7560362; rs2059425; rs11900338; rs6727278; rs10164414; rs10189894; rs16861173; rs4972520; rs3754761; rs7595061; rs1863169; rs3769302; rs10185453; rs10930574; rs13010326; rs17705739; rs17706217; rs11895261; rs16861125; rs7560268; rs13413998; rs16861133; rs7584778; rs10202019; rs17756834; rs3769271; rs1104635; rs6713917; rs2357953; rs13015601; rs16861227; rs6712008; rs6433385; rs11885026; rs3769225; rs13402426; rs17705978; rs2100282; rs3769248; rs12105095; rs1823611; rs1559628; rs16861058; rs3820849; rs11890301; rs3769282; rs17758391; rs12474484; rs1974922; rs3769212; rs12693011; rs3769233; rs16861028; rs3754765; rs7604177; rs7568605; rs3769224; rs13418299; rs11695398; rs3769297; rs7599438; rs2121482; rs12618296; rs13023428; rs3769298; rs7598352; rs12990313; rs17302307; rs2113809; rs2553012; rs2290377; rs10170710; rs16861143; rs1973037; rs17706349; rs7575398; rs3769277; rs6746673; rs7607466; rs7608634; rs6717835; rs6752750; rs2009432; rs11688147; rs1451449; rs16823271; rs16860979; rs3769293; rs17756942; rs7585995; rs12616563; rs13404300; rs12463742; rs2042563; rs11682431; rs1863174; rs7560531; rs16860846; rs17755348; rs10199849; rs7420491; rs12477872; rs6738441; rs13420020; rs2194719; rs16861169; rs17705834; rs1867940; rs1559627; rs7600980; rs7595331; rs4972859; rs11884510; rs7560324; rs9677534; rs16861145; rs7562873; rs7580906; rs6729880; rs2676524; rs17705429; rs3769262; rs16861122; rs10187070; rs7608030; rs3769314; rs1863170; rs2676503; rs16860920; rs17706710; rs4332889; rs4989335; rs2257236; rs16860971; rs16860902; rs2553002; rs17706647; rs10189033; rs7587105; rs3769274; rs34469004; rs1823152; rs7585997; rs2242078; rs3769296; rs2553013; rs3769286; rs6711789; rs10204287; rs7587163; rs12464956; rs7583805; rs3813816; rs3813814; rs3813815; rs12469149; rs1868902; rs17853967; rs2166589; rs17852174; rs17852173; rs34347501; rs17853965; rs17857212; rs17857211; rs17853966; rs34965602; rs35955389; rs35272219; rs34016193; rs4972522; rs35065596; rs2357951; rs10529049; rs6741466; rs35737387; rs35829384; rs35493140; rs6738226; rs13411673; rs13400195; rs28735753; rs2553017; rs3835833; rs11332643; rs34252442; rs2161995; rs4972863; rs11310664; rs10692589; rs13428473; rs2161992; rs34885124; rs34968378; rs34662247; rs17740794; rs6433383; rs33999083; rs35205075; rs9808261; rs10171443; rs3820853; rs7557502; rs4972395; rs6746973; rs7561875; rs34659758; rs35718833; rs35162997; rs6741323; rs36012969; rs34980526; rs35329847; rs1867941; rs17759303; rs5836398; rs3769269; rs13427351; rs35827899; rs2194722; rs36113414; rs12986785; rs35648661; rs12995177; rs13391745; rs3769242; rs4027228; rs11417660; rs6723668; rs34174605; rs12474179; rs35253091; rs35856929; rs28722900; rs35433656; rs2357949; rs5836393; rs2553007; rs10676347; rs34542253; rs6755495; rs3769261; rs10191046; rs35819123; rs3769291; rs35341757; rs41268707; rs4972867; rs1596939; rs10172751; rs36094379; rs10657436; rs3769270; rs10617167; rs12996098; rs7602060; rs16861229; rs13428253; rs2468393; rs34374899; rs13029377; rs11300988; rs13012379; rs13011903; rs3769275; rs6712503; rs34481344; rs6748395; rs12986507; rs4246609; rs35316293; rs34697922; rs12473928; rs4972392; rs2081405; rs11287069; rs34563405; rs36119911; rs35111907; rs34574292; rs17757038; rs2121480; rs13015044; rs6722150; rs5836397; rs11427320; rs10569704; rs35928628; rs34402027; rs35527769; rs4991217; rs34753967; rs7573789; rs4541226; rs34859505; rs11370778; rs3769226; rs34628143; rs7603626; rs10170449; rs35547142; rs16860916; rs7425393; rs34582271; rs3064820; rs35845779; rs3835836; rs34225662; rs1348875; rs4561631; rs34408137; rs12998691; rs34628734; rs17760326; rs17703556; rs34753986; rs12105073; rs34546255; rs34432594; rs11361687; rs35350567; rs3769214; rs2676526; rs17706854; rs16861005; rs34330226; rs16860843; rs2161993; rs35837492; rs35069507; rs4142876; rs2884347; rs28495224; rs6748068; rs10683076; rs6707359; rs13033326; rs35107898; rs10670731; rs10678095; rs35628039; rs11397173; rs7559060; rs2859986; rs6714475; rs11320644; rs35993508; rs35098984; rs13012583; rs11885658; rs9808266; rs3068994; rs3835842; rs4414651; rs11687902; rs17755063; rs13005651; rs35414922; rs34869229; rs35108055; rs3769290; rs34232766; rs2676508; rs11363639; rs35838825; rs13001156; rs35815206; rs35700682; rs11335525; rs34349794; rs34661805; rs11687990; rs6723229; rs35355059; rs13404217; rs5836392; rs35190971; rs28690928; rs34088634; rs2113805; rs10181126; rs13422397; rs4270317; rs16861061; rs3214814; rs34039464; rs13025467; rs10191030; rs5836396; rs35723638; rs6759958; rs3835832; rs6713148; rs35846416; rs3834118; rs35777824; rs35675586; rs34815555; rs10534192; rs12469665; rs36008407; rs34201568; rs16861022; rs34927431; rs3835839; rs35369696; rs34942777; rs10202335; rs16860929; rs11393374; rs3769257; rs34225159; rs13419593; rs11324142; rs10689863; rs35562019; rs6728026; rs11287070; rs4265981; rs4972860; rs35994732; rs13023047; rs34230538; rs34464621; rs13012408; rs35730673; rs35357095; rs41414646; rs16861224; rs28706049; rs35622081; rs3835829; rs34888398; rs3769303; rs10687838; rs10710442; rs13011386; rs10559845; rs35350792; rs16861024; rs12991365; rs4619569; rs7581501; rs1530591; rs3769255; rs6754041; rs13025720; rs7608306; rs11397728; rs11438066; rs34188107; rs13392443; rs10683075; rs34715681; rs4525664; rs3835835; rs4444487; rs35478755; rs17707776; rs35760218; rs11904533; rs34276524; rs11432810; rs7592554; rs34315927; rs6756984; rs2290373; rs35107054; rs11354267; rs10209464; rs34085583; rs13383922; rs34552979; rs12991440; rs16860931; rs35750313; rs41473447; rs35223351; rs1863171; rs34857020; rs35348346; rs13000099; rs35994872; rs35052083; rs13036009; rs12478977; rs35379821; rs13391286; rs3835841; rs11275229; rs35379336; rs35600229; rs6746193; rs35184677; rs34628545; rs34964737; rs34676766; rs3835838; rs34032216; rs36020160; rs34755660; rs34426407; rs34504103; rs41525849; rs3214813; rs6738094; rs28413855; rs6745058; rs34157562; rs1037444; rs34935590; rs7596096; rs13008901; rs10168072; rs9789721; rs36026673; rs12618076; rs2059424; rs10670921; rs2553005; rs2592943; rs41514546; rs10534191; rs5010643; rs35490143; rs13403194; rs9789687; rs2468390; rs34646146; rs35310553; rs12998682; rs6744966; rs3064818; rs6721994; rs7578120; rs13385694; rs6714366; rs12621650; rs34114385; rs10177251; rs12470876; rs16860947; rs3769263; rs5836391; rs4972864; rs6726429; rs4972865; rs34989244; rs35869918; rs34011330; rs3769256; rs35073692; rs2676500; rs34148615; rs12986650; rs34614680; rs6433381; rs6742924; rs34125188; rs6433387; rs3835831; rs10639450; rs34656839; rs12992735; rs3068993; rs2123507; rs3769272; rs36226317; rs13022247; rs2258087; rs11287068; rs34266762; rs28455553; rs35640960; rs35615438; rs13022949; rs11904614; rs34151283; rs10683074; rs35789699; rs11682251; rs7580552; rs10204859; rs6728322; rs34104170; rs35253983; rs35760963; rs13018660; rs6722987; rs34015591; rs16861017; rs3835840; rs34463811; rs7604734; rs34900749; rs11400519; rs35139952; rs5836395; rs35188853; rs10686524; rs10712222; rs35299103; rs11297899; rs34185501; rs10171819; rs35259249; rs17757877; rs7584269; rs35211988; rs34723448; rs34512516; rs1011346; rs1111510; rs34132930; rs16861179; rs35418559; rs11319302; rs9287959; rs12996953; rs34905241; rs1446979; rs10712221; rs3068976; rs1011345; rs10185458; rs4433966; rs4972866; rs13408604; rs11374637; rs35427895; rs13034647; rs10685817; rs35579151; rs35778335; rs13428252; rs16860869; rs13418635; rs35071642; rs28635235; rs13430663; rs3769305; rs10636582; rs3835837; rs34724361; rs12616206; rs11446027; rs35310710; rs12473930; rs35905755; rs36054744; rs3769259; rs10551723; rs7582422; rs6728688; rs9807937; rs10203896; rs2553006; rs7598685; rs11451480; rs11690900; rs7557672; rs35117417; rs2194714; rs2553019; rs35366675; rs34885773; rs5836394; rs34210584; rs35913662; rs12053036; rs35125373; rs4514849; rs3856432; rs35069550; rs35979085; rs2884282; rs13418715; rs36036729; rs12986495; rs17708115; rs16861064; rs13383192; rs2042564; rs3835834; rs1031224; rs35534671; rs3813813; rs7587443; rs10172562; rs10187560; rs10198781; rs10497403; rs10930575; rs11884105; rs11889295; rs11895028; rs12463612; rs12611769; rs12614340; rs12987269; rs13000843; rs13023591; rs1349494; rs1349495; rs1349496; rs1349497; rs1349498; rs1349499; rs1376555; rs16861253; rs34532952; rs34875551; rs35599077; rs6433389; rs6707813; rs7557133; rs767072; rs865641

# Macromolecular_Interacting_Partner_62_General_References:
9856955; 11707077; 10777494

# Macromolecular_Interacting_Partner_62_References:
16613879; 16644915; 16973695; 17132651

# Macromolecular_Interacting_Partner_63_ID:
7759

# Macromolecular_Interacting_Partner_63_Name:
A kinase anchor protein 1, mitochondrial precursor

# Macromolecular_Interacting_Partner_63_Synonyms:
Protein kinase A- anchoring protein 1; PRKA1; A-kinase anchor protein 149 kDa; AKAP 149; Dual specificity A-kinase-anchoring protein 1; D-AKAP-1; Spermatid A-kinase anchor protein 84; S-AKAP84

# Macromolecular_Interacting_Partner_63_Gene_Name:
AKAP1

# Macromolecular_Interacting_Partner_63_Protein_Sequence:
>A kinase anchor protein 1, mitochondrial precursor
MAIQFRSLFPLALPGMLALLGWWWFFSRKKGHVSSHDEQQVEAGAVQLRADPAIKEPLPV
EDVCPKVVSTPPSVTEPPEKELSTVSKLPAEPPALLQTHPPCRRSESSGILPNTTDMRLR
PGTRRDDSTKLELALTGGEAKSIPLECPLSSPKGVLFSSKSAEVCKQDSPFSRVPRKVQP
GYPVVPAEKRSSGERARETGGAEGTGDAVLGEKVLEEALLSREHVLELENSKGPSLASLE
GEEDKGKSSSSQVVGPVQEEEYVAEKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGV
EGELGNEESLDRNEEGLDRNEEGLDRNEESLDRNEEGLDRNEEIKRAAFQIISQVISEAT
EQVLATTVGKVAGRVCQASQLQGQKEESCVPVHQKTVLGPDTAEPATAEAAVAPPDAGLP
LPGLPAEGSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLASCLALTTPSEELPDRAGI
LVEDATCVTCMSDSSQSVPLVASPGHCSDSFSTSGLEDSCTETSSSPRDKAITPPLPEST
VPFSNGVLKGELSDLGAEDGWTMDAEADHSGGSDRNSMDSVDSCCSLKKTESFQNAQAGS
NPKKVDLIIWEIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS
QHHVDKALNLIGKKFKELNLTNIYAPPLPSLALPSLPMTSWLMLPDGITVEVIVVNQVNA
GHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEITVICAAPGADGAWWRAQVV
ASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVMPLSDDDQFSP
EADAAMSEMTGNTALLAQVTSYSPTGLPLIQLWSVVGDEVVLINRSLVERGLAQWVDSYY
TSL

# Macromolecular_Interacting_Partner_63_Number_of_Residues:
903

# Macromolecular_Interacting_Partner_63_Molecular_Weight:
97342

# Macromolecular_Interacting_Partner_63_Theoretical_pI:
4.58

# Macromolecular_Interacting_Partner_63_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_63_General_Function:
Not Available

# Macromolecular_Interacting_Partner_63_Specific_Function:
Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane

# Macromolecular_Interacting_Partner_63_Pathway:
Not Available

# Macromolecular_Interacting_Partner_63_Reaction:
Not Available

# Macromolecular_Interacting_Partner_63_Pfam_Domain_Function:
PF00013:KH_1;
PF00567:TUDOR

# Macromolecular_Interacting_Partner_63_Signals:
1-35

# Macromolecular_Interacting_Partner_63_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_63_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_63_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_63_GenBank_ID_Protein:
1507824

# Macromolecular_Interacting_Partner_63_SwissProt_ID:
AKAP1_HUMAN (Q92667)

# Macromolecular_Interacting_Partner_63_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_63_Genecard_id:
AKAP1

# Macromolecular_Interacting_Partner_63_Geneatlas_id:
AKAP1

# Macromolecular_Interacting_Partner_63_hgnc_id:
HGNC:367

# Macromolecular_Interacting_Partner_63_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_63_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_63_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_63_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane (Potential)

# Macromolecular_Interacting_Partner_63_Gene_Sequence:
>2712 bp
ATGGCAATCCAGTTCCGTTCGCTCTTCCCCTTGGCATTGCCTGGGATGCTGGCGCTCCTC
GGCTGGTGGTGGTTTTTCTCTCGTAAAAAAGGCCATGTCAGCAGCCATGATGAGCAGCAG
GTGGAGGCTGGTGCTGTGCAGCTGAGGGCTGACCCTGCCATCAAGGAACCTCTCCCCGTG
GAAGACGTCTGTCCCAAAGTAGTGTCCACACCCCCCAGTGTCACAGAGCCTCCAGAAAAG
GAACTGTCCACCGTGAGCAAGCTGCCTGCAGAGCCCCCAGCATTGCTCCAGACACACCCA
CCTTGCCGAAGATCAGAGTCCTCGGGCATTCTTCCTAACACCACAGACATGAGATTGCGA
CCAGGAACACGCAGAGATGACAGTACAAAGCTGGAGCTAGCCCTGACAGGTGGTGAAGCC
AAATCGATTCCTCTAGAGTGCCCCCTTTCATCCCCAAAGGGTGTACTATTCTCCAGCAAA
TCAGCTGAGGTGTGTAAGCAAGATTCCCCCTTCAGCAGGGTGCCAAGGAAGGTCCAGCCA
GGCTACCCCGTAGTCCCCGCAGAGAAGCGTAGCTCTGGGGAGAGGGCAAGAGAGACAGGT
GGGGCCGAAGGGACTGGTGATGCCGTGTTGGGGGAAAAGGTGCTTGAAGAAGCTCTGTTG
TCTCGGGAGCATGTCTTGGAATTGGAGAACAGCAAGGGCCCCAGCCTGGCCTCTTTAGAG
GGGGAAGAAGATAAGGGGAAGAGCAGCTCATCCCAGGTGGTGGGGCCAGTGCAGGAGGAA
GAGTATGTAGCAGAGAAGTTGCCAAGTAGGTTCATCGAGTCGGCTCACACAGAGCTGGCA
AAGGACGATGCGGCGCCAGCACCCCCAGTCGCAGACGCCAAAGCCCAGGACAGAGGTGTC
GAGGGAGAACTGGGCAATGAGGAGAGCTTGGATAGAAATGAGGAGGGCTTGGATAGAAAT
GAGGAGGGCTTGGATAGAAATGAGGAGAGCTTGGATAGAAATGAGGAGGGCTTGGATAGA
AATGAGGAGATTAAGCGGGCTGCCTTCCAGATAATCTCCCAAGTGATCTCAGAAGCAACC
GAACAGGTGCTGGCCACCACGGTTGGCAAGGTTGCAGGTCGTGTGTGTCAGGCCAGTCAG
CTCCAAGGGCAGAAGGAAGAGAGCTGTGTCCCAGTTCACCAGAAAACTGTCCTGGGCCCA
GACACTGCGGAGCCTGCCACAGCAGAGGCAGCTGTTGCCCCGCCGGATGCTGGCCTCCCC
TTGCCAGGCCTACCAGCAGAGGGCTCACCACCACCAAAGACCTACGTGAGCTGCCTGAAG
AGCCTTCTGTCCAGCCCCACCAAGGACAGTAAGCCAAATATCTCTGCACACCACATCTCC
CTGGCCTCCTGCCTGGCACTGACCACCCCCAGTGAAGAGTTGCCGGACCGGGCAGGCATC
CTGGTGGAAGATGCCACCTGTGTCACCTGCATGTCAGACAGCAGCCAAAGTGTCCCTTTG
GTGGCTTCTCCAGGACACTGCTCAGATTCTTTCAGCACTTCAGGGCTTGAAGACTCTTGC
ACAGAGACCAGCTCGAGCCCCAGGGACAAGGCCATCACCCCGCCACTGCCAGAAAGTACT
GTGCCCTTCAGCAATGGGGTGCTGAAGGGGGAGTTGTCAGACTTGGGGGCTGAGGATGGA
TGGACCATGGATGCGGAAGCAGATCATTCAGGAGGTTCTGACAGGAACAGCATGGATTCC
GTGGATAGCTGTTGCAGTCTCAAGAAGACTGAGAGCTTCCAAAATGCCCAGGCAGGCTCC
AACCCTAAGAAGGTCGACCTCATCATCTGGGAGATCGAGGTGCCAAAGCACTTAGTCGGT
CGGCTAATTGGCAAGCAGGGGCGCTATGTGAGTTTTCTGAAGCAAACATCTGGTGCCAAG
ATCTACATTTCAACCCTGCCTTACACCCAGAGCGTCCAGATCTGCCACATAGAAGGCTCT
CAACATCATGTAGACAAAGCGCTGAACTTGATTGGGAAGAAGTTCAAAGAGCTGAACCTC
ACCAATATCTACGCTCCCCCATTGCCTTCACTGGCACTGCCTTCTCTGCCGATGACATCC
TGGCTCATGCTGCCTGATGGCATCACCGTGGAGGTCATTGTGGTCAACCAGGTCAATGCC
GGGCACCTGTTCGTGCAGCAGCACACACACCCTACCTTCCACGCGCTGCGCAGCCTCGAC
CAGCAGATGTACCTCTGTTACTCTCAGCCTGGAATCCCCACCTTGCCCACCCCAGTGGAA
ATAACGGTCATCTGTGCCGCCCCTGGTGCGGACGGGGCCTGGTGGCGAGCCCAAGTGGTT
GCCTCCTACGAGGAGACCAACGAAGTGGAGATTCGATACGTGGACTACGGCGGATATAAG
AGGGTGAAAGTAGACGTGCTCCGGCAAATCAGGTCTGACTTTGTCACCCTGCCGTTTCAG
GGAGCAGAAGTCCTTCTGGACAGTGTGATGCCCCTGTCAGACGATGACCAGTTTTCACCG
GAAGCAGATGCCGCCATGAGCGAGATGACGGGGAATACAGCACTGCTTGCTCAGGTGACA
AGTTACAGTCCAACTGGTCTTCCTCTGATTCAGCTGTGGAGTGTGGTTGGAGATGAAGTG
GTGTTGATAAACCGGTCCCTGGTGGAGCGAGGCCTTGCCCAGTGGGTAGACAGCTACTAC
ACAAGCCTTTGA

# Macromolecular_Interacting_Partner_63_GenBank_ID_Gene:
X97335

# Macromolecular_Interacting_Partner_63_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_63_Locus:
17q21-q23

# Macromolecular_Interacting_Partner_63_SNPs:
rs2230770; rs17761023; rs2230772; rs1050515; rs11658676; rs7212834; rs724754; rs4583; rs917926; rs2270278; rs2160115; rs7342869; rs3785484; rs6967; rs3095505; rs4794699; rs3826296; rs6503792; rs15944; rs4794698; rs9897093; rs3785483; rs2270276; rs17220495; rs3833091; rs2058578; rs11657718; rs3837801; rs11654787; rs2270277; rs3785482; rs916816; rs3094438; rs11079278; rs880135; rs2241072; rs2269819; rs11655568; rs2301702; rs880134; rs2241073; rs11655412; rs880136; rs886282; rs11651918; rs2270274; rs9891037; rs17833741; rs9890074; rs9890807; rs3785487; rs3094444; rs9892694; rs11655661; rs3094445; rs9890757; rs16958053; rs8068737; rs11079277; rs2270275; rs11538740; rs35359994; rs34535433; rs2230771; rs17849362; rs17833723; rs1050516; rs35038519; rs10587636; rs12940245; rs34927341; rs34179370; rs35726520; rs8080048; rs35288743; rs34602814; rs11436603; rs3785485; rs34234955; rs35359426; rs11290580; rs3180535; rs917925; rs33944971; rs1050591; rs28697125; rs35049727; rs34015652; rs34338223; rs3826297; rs10595533; rs12940974; rs11382454; rs34096045; rs7224229; rs35145417; rs5821162; rs11286844; rs34569749; rs9913849; rs10647360; rs5821160; rs3842368; rs9905737; rs2332784; rs10555253; rs2332783; rs28434643; rs35407491; rs7211477; rs3785486; rs2214288; rs11464527; rs4794700; rs36073787; rs3054874; rs5821161; rs7502469; rs3837802; rs35651178; rs759259; rs2077329; rs35298508; rs35209435; rs1007462; rs1007463; rs11655326; rs12452128; rs12602561; rs1468753; rs1557756; rs1557757; rs17220558; rs2332846; rs3094439; rs3094440; rs3094441; rs3095502; rs3095504; rs34345490; rs4794697; rs6503791; rs7210969; rs721425; rs721426; rs721427; rs7215938; rs7217371; rs757097; rs8071417; rs876627; rs876628; rs886281; rs9895634; rs997722; rs997723; rs998113

# Macromolecular_Interacting_Partner_63_General_References:
8769136; 7499250

# Macromolecular_Interacting_Partner_63_References:
16645149; 16899636; 17135396

# Macromolecular_Interacting_Partner_64_ID:
7894

# Macromolecular_Interacting_Partner_64_Name:
Relaxin receptor 1

# Macromolecular_Interacting_Partner_64_Synonyms:
Relaxin family peptide receptor 1; Leucine-rich repeat-containing G-protein coupled receptor 7

# Macromolecular_Interacting_Partner_64_Gene_Name:
RXFP1

# Macromolecular_Interacting_Partner_64_Protein_Sequence:
>Relaxin receptor 1
MTSGSVFFYILIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADED
NCGDNNGWSMQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRA
VPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLY
LSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDK
PLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDEL
DLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQ
RMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTC
FGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWM
ESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGF
IVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYG
SMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGT
ITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWV
EMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS

# Macromolecular_Interacting_Partner_64_Number_of_Residues:
757

# Macromolecular_Interacting_Partner_64_Molecular_Weight:
86994

# Macromolecular_Interacting_Partner_64_Theoretical_pI:
8.11

# Macromolecular_Interacting_Partner_64_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_64_General_Function:
Not Available

# Macromolecular_Interacting_Partner_64_Specific_Function:
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP

# Macromolecular_Interacting_Partner_64_Pathway:
Not Available

# Macromolecular_Interacting_Partner_64_Reaction:
Not Available

# Macromolecular_Interacting_Partner_64_Pfam_Domain_Function:
PF00001:7tm_1;
PF00057:Ldl_recept_a;
PF00560:LRR_1

# Macromolecular_Interacting_Partner_64_Signals:
1-22

# Macromolecular_Interacting_Partner_64_Transmembrane_Regions:
410-430
444-464
487-507
528-548
578-598
630-650
652-672

# Macromolecular_Interacting_Partner_64_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_64_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_64_GenBank_ID_Protein:
10441730

# Macromolecular_Interacting_Partner_64_SwissProt_ID:
RXFP1_HUMAN (Q9HBX9)

# Macromolecular_Interacting_Partner_64_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_64_Genecard_id:
RXFP1

# Macromolecular_Interacting_Partner_64_Geneatlas_id:
RXFP1

# Macromolecular_Interacting_Partner_64_hgnc_id:
HGNC:19718

# Macromolecular_Interacting_Partner_64_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_64_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_64_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_64_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_64_Gene_Sequence:
>2274 bp
ATGACATCTGGTTCTGTCTTCTTCTACATCTTAATTTTTGGAAAATATTTTTCTCATGGG
GGTGGACAGGATGTCAAGTGCTCCCTTGGCTATTTCCCCTGTGGGAACATCACAAAGTGC
TTGCCTCAGCTCCTGCACTGTAACGGTGTGGACGACTGCGGGAATCAGGCCGATGAGGAC
AACTGTGGAGACAACAATGGATGGTCCATGCAATTTGACAAATATTTTGCCAGTTACTAC
AAAATGACTTCCCAATATCCTTTTGAGGCAGAAACACCTGAATGTTTGGTCGGTTCTGTG
CCAGTGCAATGTCTTTGCCAAGGTCTGGAGCTTGACTGTGATGAAACCAATTTACGAGCT
GTTCCATCGGTTTCTTCAAATGTGACTGCAATGTCACTTCAGTGGAACTTAATAAGAAAG
CTTCCTCCTGATTGCTTCAAGAATTATCATGATCTTCAGAAGCTGTACCTGCAAAACAAT
AAGATTACATCCATCTCCATCTATGCTTTCAGAGGACTGAATAGCCTTACTAAACTGTAT
CTCAGTCATAACAGAATAACCTTCCTGAAGCCGGGTGTTTTTGAAGATCTTCACAGACTA
GAATGGCTGATAATTGAAGATAATCACCTCAGTCGAATTTCCCCACCAACATTTTATGGA
CTAAATTCTCTTATTCTCTTAGTCCTGATGAATAACGTCCTCACCCGTTTACCTGATAAA
CCTCTCTGTCAACACATGCCAAGACTACATTGGCTGGACCTTGAAGGCAACCATATCCAT
AATTTAAGAAATTTGACTTTTATTTCCTGCAGTAATTTAACTGTTTTAGTGATGAGGAAA
AACAAAATTAATCACTTAAATGAAAATACTTTTGCACCTCTCCAGAAACTGGATGAATTG
GATTTAGGAAGTAATAAGATTGAAAATCTTCCACCGCTTATATTCAAGGACCTGAAGGAG
CTGTCACAATTGAATCTTTCCTATAATCCAATCCAGAAAATTCAAGCAAACCAATTTGAT
TATCTTGTCAAACTCAAGTCTCTCAGCCTAGAAGGGATTGAAATTTCAAATATCCAACAA
AGGATGTTTAGACCTCTTATGAATCTCTCTCACATATATTTTAAGAAATTCCAGTACTGT
GGGTATGCACCACATGTTCGCAGCTGTAAACCAAACACTGATGGAATTTCATCTCTAGAG
AATCTCTTGGCAAGCATTATTCAGAGAGTATTTGTCTGGGTTGTATCTGCAGTTACCTGC
TTTGGAAACATTTTTGTCATTTGCATGCGACCTTATATCAGGTCTGAGAACAAGCTGTAT
GCCATGTCAATCATTTCTCTCTGCTGTGCCGACTGCTTAATGGGAATATATTTATTCGTG
ATCGGAGGCTTTGACCTAAAGTTTCGTGGAGAATACAATAAGCATGCGCAGCTGTGGATG
GAGAGTACTCATTGTCAGCTTGTAGGATCTTTGGCCATTCTGTCCACAGAAGTATCAGTT
TTACTGTTAACATTTCTGACATTGGAAAAATACATCTGCATTGTCTATCCTTTTAGATGT
GTGAGACCTGGAAAATGCAGAACAATTACAGTTCTGATTCTCATTTGGATTACTGGTTTT
ATAGTGGCTTTCATTCCATTGAGCAATAAGGAATTTTTCAAAAACTACTATGGCACCAAT
GGAGTATGCTTCCCTCTTCATTCAGAAGATACAGAAAGTATTGGAGCCCAGATTTATTCA
GTGGCAATTTTTCTTGGTATTAATTTGGCCGCATTTATCATCATAGTTTTTTCCTATGGA
AGCATGTTTTATAGTGTTCATCAAAGTGCCATAACAGCAACTGAAATACGGAATCAAGTT
AAAAAAGAGATGATCCTTGCCAAACGTTTTTTCTTTATAGTATTTACTGATGCATTATGC
TGGATACCCATTTTTGTAGTGAAATTTCTTTCACTGCTTCAGGTAGAAATACCAGGTACC
ATAACCTCTTGGGTAGTGATTTTTATTCTGCCCATTAACAGTGCTTTGAACCCAATTCTC
TATACTCTGACCACAAGACCATTTAAAGAAATGATTCATCGGTTTTGGTATAACTACAGA
CAAAGAAAATCTATGGACAGCAAAGGTCAGAAAACATATGCTCCATCATTCATCTGGGTG
GAAATGTGGCCACTGCAGGAGATGCCACCTGAGTTAATGAAGCCGGACCTTTTCACATAC
CCCTGTGAAATGTCACTGATTTCTCAATCAACGAGACTCAATTCCTATTCATGA

# Macromolecular_Interacting_Partner_64_GenBank_ID_Gene:
AF190500

# Macromolecular_Interacting_Partner_64_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_64_Locus:
4q32.1

# Macromolecular_Interacting_Partner_64_SNPs:
rs1463348; rs885180; rs1542384; rs936095; rs11100191; rs11934794; rs9990960; rs6845779; rs11737507; rs9307978; rs6832186; rs6844143; rs936094; rs9995331; rs7659132; rs11943598; rs4295218; rs4289401; rs4234922; rs7698410; rs4314236; rs7698657; rs11940491; rs10857314; rs11736805; rs6536355; rs12505765; rs10857315; rs9284667; rs11938976; rs6536353; rs745279; rs10023342; rs10019059; rs11932571; rs2168294; rs9990723; rs4364213; rs12501345; rs12499002; rs1077094; rs1902212; rs4132807; rs10857317; rs11947859; rs11932894; rs6815429; rs11946226; rs6833282; rs7695888; rs11939331; rs9995272; rs6823496; rs10030877; rs11935854; rs11944623; rs11930121; rs9307977; rs6857344; rs17219243; rs13136137; rs1378462; rs7695656; rs11100192; rs10014194; rs4639026; rs13101591; rs10001153; rs16999138; rs7356187; rs9985723; rs11725333; rs9307979; rs7684527; rs7670971; rs6842018; rs4132808; rs12649106; rs11942473; rs13135649; rs6846141; rs2085236; rs12108216; rs11942408; rs7694443; rs9990783; rs7676547; rs4691511; rs11724401; rs12511076; rs11940862; rs6846122; rs4691510; rs7437421; rs9942149; rs6839372; rs11736867; rs2085235; rs13146852; rs1075700; rs7435788; rs7695391; rs2346794; rs6819359; rs936096; rs10029112; rs17037590; rs4435695; rs10034157; rs13139892; rs13136243; rs12643757; rs4386553; rs7695283; rs13141628; rs9683581; rs936092; rs17285317; rs10028473; rs7698694; rs4691513; rs6419290; rs10025743; rs10025895; rs7661878; rs6846487; rs12641973; rs13136957; rs11943643; rs7674953; rs4690906; rs13140159; rs17219611; rs1455456; rs4513519; rs7679484; rs7678831; rs7685141; rs10000021; rs7685470; rs6536351; rs10011824; rs36184530; rs28609262; rs34672645; rs35328564; rs9991170; rs12331309; rs33961399; rs10032633; rs11329980; rs35396128; rs34848260; rs6810787; rs35997787; rs35163731; rs35535055; rs36045439; rs936093; rs4552416; rs5863323; rs34817090; rs10572157; rs28695669; rs33983496; rs1455461; rs33969911; rs28605227; rs35223501; rs9991174; rs28612158; rs10006598; rs33977260; rs35159208; rs11295815; rs12644364; rs34793719; rs34792029; rs13141580; rs33923388; rs33982853; rs28869308; rs34199511; rs35389897; rs12503271; rs13105252; rs34601334; rs6851129; rs35731966; rs28754672; rs28581217; rs5863327; rs11941698; rs7435807; rs28654650; rs4432709; rs11393653; rs7671410; rs33965184; rs10542704; rs34380582; rs10543329; rs28674480; rs5863326; rs28452019; rs35862687; rs11936458; rs10642204; rs35907336; rs2124272; rs6841826; rs35788162; rs7677564; rs4419435; rs34857680; rs6849042; rs36225948; rs35749272; rs33997155; rs34090063; rs12650392; rs35309501; rs3085268; rs36103006; rs28493977; rs10446770; rs35034196; rs7694839; rs10592491; rs34731353; rs34343762; rs6827201; rs35062917; rs35772457; rs7695640; rs28616008; rs34520291; rs33976290; rs28624821; rs35484770; rs13105791; rs28486085; rs35327281; rs33966083; rs35664187; rs34746177; rs34978517; rs28791218; rs4395459; rs10689456; rs13119680; rs34742858; rs34722180; rs28587988; rs35009818; rs28429055; rs5863325; rs6858010; rs2124270; rs10016797; rs28612198; rs34205257; rs2168296; rs1902216; rs10635879; rs35569418; rs7661821; rs11295662; rs35177811; rs28494564; rs35595656; rs10617905; rs7436760; rs2124273; rs35888310; rs35450140; rs34440939; rs35514598; rs35944507; rs35115542; rs36050757; rs28665713; rs11321888; rs13148612; rs10709675; rs6830218; rs12108317; rs34779491; rs34532367; rs28405073; rs35888641; rs33995741; rs6850773; rs35456599; rs35139987; rs13113834; rs35171547; rs5863329; rs34726126; rs35872724; rs33966657; rs28683083; rs13133036; rs1077093; rs6813440; rs4574356; rs35703656; rs10569719; rs7698952; rs34291609; rs4323060; rs28472896; rs10628069; rs34876450; rs34993500; rs3085270; rs28691137; rs4622953; rs13141587; rs28608826; rs35918289; rs35473062; rs34430849; rs33987156; rs10034555; rs28726169; rs35818367; rs35417208; rs34771000; rs7436628; rs13118611; rs34061612; rs6849663; rs7695167; rs28394768; rs28735792; rs28893318; rs35198537; rs5863324; rs33960450; rs28679500; rs35626162; rs4597776; rs13105822; rs35182244; rs34535185; rs7682928; rs5863330; rs34232541; rs10010666; rs34035138; rs34043123; rs35351037; rs11326047; rs34910493; rs35916009; rs9986078; rs28473004; rs28630368; rs10019251; rs10603295; rs34452355; rs35917907; rs5863328; rs4432708; rs13141146; rs6536352; rs4691512; rs35543095; rs11337872; rs28498383; rs34411044; rs7441054; rs13111939; rs34048359; rs12643639; rs35894684; rs1455455; rs6836027; rs35694947; rs10546784; rs7679227; rs34191976; rs10004043; rs10517692; rs11100188; rs13117144; rs13117197; rs13143911; rs1350025; rs1350026; rs1350027; rs1455451; rs1455452; rs17218636; rs2124271; rs35695757; rs35888873; rs6536348; rs6536349; rs6536350; rs6817922; rs6831373; rs7376673; rs7376675; rs7376692; rs7378460; rs7436885; rs7436941; rs7437425; rs7437541; rs7439270; rs7442328; rs7673986; rs7688173

# Macromolecular_Interacting_Partner_64_General_References:
10935549; 11517286; 12506116

# Macromolecular_Interacting_Partner_64_References:
17065365

# Macromolecular_Interacting_Partner_65_ID:
7934

# Macromolecular_Interacting_Partner_65_Name:
Integrin alpha-11 precursor

# Macromolecular_Interacting_Partner_65_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_65_Gene_Name:
ITGA11

# Macromolecular_Interacting_Partner_65_Protein_Sequence:
>Integrin alpha11 precursor
MDLPRGLVVAWALSLWPGFTDTFNMDTRKPRVIPGSRTAFFGYTVQQHDISGNKWLVVGA
PLETNGYQKTGDVYKCPVIHGNCTKLNLGRVTLSNVSERKDNMRLGLSLATNPKDNSFLA
CSPLWSHECGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVE
VQHFLINILKKFYIGPGQIQVGVVQYGEDVVHEFHLNDYRSVKDVVEAASHIEQRGGTET
RTAFGIEFARSEAFQKGGRKGAKKVMIVITDGESHDSPDLEKVIQQSERDNVTRYAVAVL
GYYNRRGINPETFLNEIKYIASDPDDKHFFNVTDEAALKDIVDALGDRIFSLEGTNKNET
SFGLEMSQTGFSSHVVEDGVLLGAVGAYDWNGAVLKETSAGKVIPLRESYLKEFPEELKN
HGAYLGYTVTSVVSSRQGRVYVAGAPRFNHTGKVILFTMHNNRSLTIHQAMRGQQIGSYF
GSEITSVDIDGDGVTDVLLVGAPMYFNEGRERGKVYVYELRQNRFVYNGTLKDSHSYQNA
RFGSSIASVRDLNQDSYNDVVVGAPLEDNHAGAIYIFHGFRGSILKTPKQRITASELATG
LQYFGCSIHGQLDLNEDGLIDLAVGALGNAVILWSRPVVQINASLHFEPSKINIFHRDCK
RSGRDATCLAAFLCFTPIFLAPHFQTTTVGIRYNATMDERRYTPRAHLDEGGDRFTNRAV
LLSSGQELCERINFHVLDTADYVKPVTFSVEYSLEDPDHGPMLDDGWPTTLRVSVPFWNG
CNEDEHCVPDLVLDARSDLPTAMEYCQRVLRKPAQDCSAYTLSFDTTVFIIESTRQRVAV
EATLENRGENAYSTVLNISQSANLQFASLIQKEDSDGSIECVNEERRLQKQVCNVSYPFF
RAKAKVAFRLDFEFSKSIFLHHLEIELAAGSDSNERDSTKEDNVAPLRFHLKYEADVLFT
RSSSLSHYEVKLNSSLERYDGIGPPFSCIFRIQNLGLFPIHGIMMKITIPIATRSGNRLL
KLRDFLTDEVANTSCNIWGNSTEYRPTPVEEDLRRAPQLNHSNSDVVSINCNIRLVPNQE
INFHLLGNLWLRSLKALKYKSMKIMVNAALQRQFHSPFIFREEDPSRQIVFEISKQEDWQ
VPIWIIVGSTLGGLLLLALLVLALWKLGFFRSARRRREPGLDPTPKVLE

# Macromolecular_Interacting_Partner_65_Number_of_Residues:
1189

# Macromolecular_Interacting_Partner_65_Molecular_Weight:
133612

# Macromolecular_Interacting_Partner_65_Theoretical_pI:
6.74

# Macromolecular_Interacting_Partner_65_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cell-substrate adhesion
Process:  cell-matrix adhesion
Process:  cellular process
Process:  cell adhesion
 ||
>>>
Component:  protein complex
Component:  receptor complex
Component:  integrin complex

# Macromolecular_Interacting_Partner_65_General_Function:
Not Available

# Macromolecular_Interacting_Partner_65_Specific_Function:
Integrin alpha-11/beta-1 is a receptor for collagen

# Macromolecular_Interacting_Partner_65_Pathway:
Not Available

# Macromolecular_Interacting_Partner_65_Reaction:
Not Available

# Macromolecular_Interacting_Partner_65_Pfam_Domain_Function:
PF01839:FG-GAP;
PF08441:Integrin_alpha2;
PF00092:VWA

# Macromolecular_Interacting_Partner_65_Signals:
1-22

# Macromolecular_Interacting_Partner_65_Transmembrane_Regions:
1143-1165

# Macromolecular_Interacting_Partner_65_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_65_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_65_GenBank_ID_Protein:
6013141

# Macromolecular_Interacting_Partner_65_SwissProt_ID:
ITA11_HUMAN (Q9UKX5)

# Macromolecular_Interacting_Partner_65_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_65_Genecard_id:
ITGA11

# Macromolecular_Interacting_Partner_65_Geneatlas_id:
ITGA11

# Macromolecular_Interacting_Partner_65_hgnc_id:
HGNC:6136

# Macromolecular_Interacting_Partner_65_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_65_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_65_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_65_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_65_Gene_Sequence:
>3570 bp
ATGGACCTGCCCAGGGGCCTGGTGGTGGCCTGGGCGCTCAGCCTGTGGCCAGGGTTCACG
GACACCTTCAACATGGACACCAGGAAGCCCCGGGTCATCCCTGGCTCCAGGACCGCCTTC
TTTGGCTACACAGTGCAGCAGCACGACATCAGTGGCAATAAGTGGCTGGTCGTGGGCGCC
CCACTGGAAACCAATGGCTACCAGAAGACGGGAGACGTGTACAAGTGTCCAGTGATCCAC
GGGAACTGCACCAAACTCAACCTGGGAAGGGTCACCCTGTCCAACGTGTCCGAGCGGAAA
GACAACATGCGCCTCGGCCTTAGTCTCGCCACCAACCCCAAGGACAACAGCTTCCTGGCC
TGCAGCCCCCTCTGGTCTCATGAGTGTGGGAGCTCCTACTACACCACAGGGATGTGTTCA
AGAGTCAACTCCAACTTCAGGTTCTCCAAGACCGTGGCCCCAGCTCTCCAAAGGTGCCAG
ACCTACATGGACATCGTCATTGTCCTGGATGGCTCCAACAGCATCTACCCCTGGGTGGAG
GTTCAGCACTTCCTCATCAACATCCTGAAAAAGTTTTACATTGGCCCAGGGCAGATCCAG
GTTGGAGTTGTGCAGTATGGCGAAGATGTGGTGCATGAGTTTCACCTCAATGACTACAGG
TCTGTAAAAGATGTGGTGGAAGCTGCCAGCCACATTGAGCAGAGAGGAGGAACAGAGACC
CGGACGGCATTTGGCATTGAATTTGCACGCTCAGAGGCTTTCCAGAAGGGTGGAAGGAAA
GGAGCCAAGAAGGTGATGATTGTCATCACAGATGGGGAGTCCCACGACAGCCCAGACCTG
GAGAAGGTGATCCAGCAAAGCGAAAGAGACAACGTAACAAGATATGCGGTGGCCGTCCTG
GGCTACTACAACCGCAGGGGGATCAATCCAGAAACTTTTCTAAATGAAATCAAATACATC
GCCAGTGACCCTGATGACAAGCACTTCTTCAATGTCACTGATGAGGCTGCCTTGAAGGAC
ATTGTCGATGCCCTGGGGGACAGAATCTTCAGCCTGGAAGGCACCAACAAGAACGAGACC
TCCTTTGGGCTGGAGATGTCACAGACGGGCTTTTCCTCGCACGTGGTGGAGGATGGGGTT
CTGCTGGGAGCCGTCGGTGCCTATGACTGGAATGGAGCTGTGCTAAAGGAGACGAGTGCC
GGGAAGGTCATTCCTCTCCGCGAGTCCTACCTGAAAGAGTTCCCCGAGGAGCTCAAGAAC
CATGGTGCATACCTGGGGTACACAGTCACATCGGTCGTGTCCTCCAGGCAGGGGCGAGTG
TACGTGGCCGGAGCCCCCCGGTTCAACCACACGGGCAAGGTCATCCTGTTCACCATGCAC
AACAACCGGAGCCTCACCATCCACCAGGCTATGCGGGGCCAGCAGATAGGCTCTTACTTT
GGGAGTGAAATCACCTCGGTGGACATCGACGGCGACGGCGTGACTGATGTCCTGCTGGTG
GGCGCACCCATGTACTTCAACGAGGGCCGTGAGCGAGGCAAGGTGTACGTCTATGAGCTG
AGACAGAACCGGTTTGTTTATAACGGAACGCTAAAGGATTCACACAGTTACCAGAATGCC
CGATTTGGGTCCTCCATTGCCTCAGTTCGAGACCTCAACCAGGATTCCTACAATGACGTG
GTGGTGGGAGCCCCCCTGGAGGACAACCACGCAGGAGCCATCTACATCTTCCACGGCTTC
CGAGGCAGCATCCTGAAGACACCTAAGCAGAGAATCACAGCCTCAGAGCTGGCTACCGGC
CTCCAGTATTTTGGCTGCAGCATCCACGGGCAATTGGACCTCAATGAGGATGGGCTCATC
GACCTGGCAGTGGGAGCCCTTGGCAACGCTGTGATTCTGTGGTCCCGCCCAGTGGTTCAG
ATCAATGCCAGCCTCCACTTTGAGCCATCCAAGATCAACATCTTCCACAGAGACTGCAAG
CGCAGTGGCAGGGATGCCACCTGCCTGGCCGCCTTCCTCTGCTTCACGCCCATCTTCCTG
GCACCCCATTTCCAAACAACAACTGTTGGCATCAGATACAACGCCACCATGGATGAGAGG
CGGTATACACCGAGGGCCCACCTGGACGAGGGCGGGGACCGATTCACCAACAGAGCCGTA
CTGCTCTCCTCCGGCCAGGAGCTCTGTGAGCGGATCAACTTCCATGTCCTGGACACTGCT
GACTACGTGAAGCCAGTGACCTTCTCAGTCGAGTATTCCCTGGAGGACCCTGACCATGGC
CCCATGCTGGACGACGGCTGGCCCACCACTCTCAGAGTCTCGGTGCCCTTCTGGAACGGC
TGCAATGAGGATGAGCACTGTGTCCCTGACCTTGTGTTGGATGCCCGGAGTGACCTGCCC
ACGGCCATGGAGTACTGCCAGAGGGTGCTGAGGAAGCCTGCGCAGGACTGCTCCGCATAC
ACGCTGTCCTTCGACACCACAGTCTTCATCATAGAGAGCACACGCCAGCGAGTGGCGGTG
GAGGCCACACTGGAGAACAGGGGCGAGAACGCCTACAGCACGGTCCTAAATATCTCGCAG
TCAGCAAACCTGCAGTTTGCCAGCTTGATCCAGAAGGAGGACTCAGACGGTAGCATTGAG
TGTGTGAACGAGGAGAGGAGGCTCCAGAAGCAAGTCTGCAACGTCAGCTATCCCTTCTTC
CGGGCCAAGGCCAAGGTGGCTTTCCGTCTTGATTTTGAGTTCAGCAAATCCATCTTCCTA
CACCACCTGGAGATCGAGCTCGCTGCAGGCAGTGACAGTAATGAGCGGGACAGCACCAAG
GAAGACAACGTGGCCCCCTTACGCTTCCACCTCAAATACGAGGCTGACGTCCTCTTCACC
AGGAGCAGCAGCCTGAGCCACTACGAGGTCAAGCTCAACAGCTCGCTGGAGAGATACGAT
GGTATCGGGCCTCCCTTCAGCTGCATCTTCAGGATCCAGAACTTGGGCTTGTTCCCCATC
CACGGGATTATGATGAAGATCACCATTCCCATCGCCACCAGGAGCGGCAACCGCCTACTG
AAGCTGAGGGACTTCCTCACGGACGAGGTAGCGAACACGTCCTGTAACATCTGGGGCAAT
AGCACTGAGTACCGGCCCACCCCAGTGGAGGAAGACTTGCGTCGTGCTCCACAGCTGAAT
CACAGCAACTCTGATGTCGTCTCCATCAACTGCAATATACGGCTGGTCCCCAACCAGGAA
ATCAATTTCCATCTACTGGGGAACCTGTGGTTGAGGTCCCTAAAAGCACTCAAGTACAAA
TCCATGAAAATCATGGTCAACGCAGCCTTGCAGAGGCAGTTCCACAGCCCCTTCATCTTC
CGTGAGGAGGATCCCAGCCGCCAGATCGTGTTTGAGATCTCCAAGCAAGAGGACTGGCAG
GTCCCCATCTGGATCATTGTAGGCAGCACCCTGGGGGGCCTCCTACTGCTGGCCCTGCTG
GTCCTGGCACTGTGGAAGCTCGGCTTCTTTAGAAGTGCCAGGCGCAGGAGGGAGCCTGGT
CTGGACCCCACCCCCAAAGTGCTGGAGTGA

# Macromolecular_Interacting_Partner_65_GenBank_ID_Gene:
AF109681

# Macromolecular_Interacting_Partner_65_Chromosome_Location:
Chromosome:15

# Macromolecular_Interacting_Partner_65_Locus:
15q23

# Macromolecular_Interacting_Partner_65_SNPs:
rs2271725; rs4777035; rs2306022; rs2306024; rs7168069; rs3736493; rs2271724; rs2306023; rs9302249; rs2292745; rs2271728; rs2271720; rs12907890; rs11629460; rs3736494; rs1122247; rs12148843; rs3817330; rs10851784; rs754399; rs898586; rs967565; rs2279101; rs1460644; rs898581; rs8041260; rs11072020; rs7176267; rs4617801; rs8039349; rs3784351; rs12443350; rs4238412; rs8038368; rs8035431; rs8036698; rs11630897; rs7174755; rs1476222; rs3784350; rs898580; rs970264; rs895137; rs11629808; rs750158; rs8035990; rs7170808; rs2306021; rs8040014; rs11635082; rs7170403; rs4776398; rs967566; rs11630977; rs6494735; rs8043127; rs7176011; rs7169854; rs7179228; rs7172210; rs4777049; rs12595773; rs11072015; rs12050670; rs11857985; rs6494736; rs8036939; rs1007617; rs11631030; rs4777033; rs7162189; rs9920271; rs7182849; rs11858032; rs895135; rs11072016; rs1115528; rs4777051; rs11857615; rs4777037; rs3736491; rs898590; rs4777048; rs11632400; rs8024010; rs748892; rs8043152; rs964691; rs4408487; rs9972560; rs5016065; rs11072021; rs11634026; rs12441197; rs1982592; rs4776397; rs12442156; rs4777036; rs898579; rs7176145; rs11855593; rs2415008; rs898584; rs11637286; rs3784345; rs7180218; rs2415001; rs11853855; rs7165618; rs11634100; rs2306012; rs4776402; rs11853718; rs1077731; rs11637293; rs2271723; rs12591673; rs7176173; rs17252387; rs8029230; rs11630284; rs11072010; rs4517737; rs8025985; rs3816612; rs16952065; rs11630928; rs6494743; rs11639240; rs11638575; rs8029838; rs1516871; rs2061564; rs7162991; rs2415000; rs3784346; rs4777041; rs7174916; rs4777046; rs6494732; rs16952005; rs4777039; rs4356422; rs7171871; rs11072014; rs16951961; rs2306013; rs2271722; rs4776404; rs8029113; rs4477640; rs16951767; rs7179347; rs7163918; rs8036876; rs1380881; rs7169899; rs1460645; rs11858758; rs11637346; rs16952001; rs4500670; rs4777034; rs10162690; rs16952059; rs11072011; rs7161791; rs11633421; rs1350733; rs6494742; rs4777040; rs11636019; rs1380883; rs8029162; rs7183704; rs8028967; rs11857338; rs2169213; rs16951778; rs2271721; rs4419008; rs11856183; rs8043262; rs1125721; rs16951774; rs9672310; rs7161871; rs898577; rs2415006; rs11637411; rs8042664; rs748891; rs16951954; rs4238414; rs11072012; rs1075991; rs3736495; rs7497049; rs11858293; rs4776405; rs8041788; rs8042999; rs2415009; rs4776394; rs16952036; rs11633614; rs2415002; rs4776399; rs3784334; rs4777042; rs11635699; rs898582; rs898589; rs6494734; rs1516869; rs3784347; rs7182350; rs2306020; rs2169214; rs11630443; rs10851785; rs7167822; rs2125998; rs16951777; rs2306015; rs11072009; rs7168991; rs2415005; rs4777047; rs16951841; rs8042862; rs898576; rs16952052; rs11072013; rs12595779; rs8028971; rs17318470; rs3784348; rs11634499; rs4776396; rs7168997; rs11852504; rs1824478; rs1020842; rs2306018; rs1813565; rs11635643; rs10851786; rs1319223; rs11072008; rs2414994; rs7164150; rs4375610; rs12440936; rs12592461; rs11637463; rs3784335; rs6494731; rs4776403; rs2306014; rs8030538; rs8030178; rs898593; rs748971; rs10400907; rs7179545; rs16951819; rs895136; rs6494738; rs2306019; rs11636813; rs8042710; rs11855998; rs1380882; rs16951816; rs12591421; rs2306025; rs4777045; rs11856272; rs3784349; rs12914609; rs10851787; rs11634149; rs2306017; rs16951746; rs7164335; rs10444851; rs2415007; rs3784336; rs12441412; rs7179598; rs1020841; rs4776400; rs1077730; rs11858012; rs1563894; rs2305078; rs11632266; rs2415003; rs4536409; rs898575; rs11635776; rs1007615; rs16952041; rs11632656; rs1975874; rs11635712; rs11072018; rs8042332; rs1124577; rs898587; rs8030943; rs1516870; rs2414996; rs7178537; rs2125999; rs4299097; rs2125997; rs6494733; rs17320635; rs16951999; rs7173365; rs16951750; rs2414998; rs967567; rs1841405; rs4777038; rs4777050; rs2306016; rs2899736; rs898583; rs16951765; rs8031003; rs11858671; rs3784342; rs2125996; rs8039820; rs4605110; rs7165305; rs7173815; rs4776395; rs898594; rs1841404; rs11637375; rs16952056; rs898574; rs9783729; rs4454914; rs716379; rs6494740; rs3784344; rs2414997; rs8031936; rs7173564; rs11852717; rs1533469; rs2271726; rs3816611; rs16951835; rs7164172; rs1542473; rs2899735; rs2414995; rs898592; rs7403417; rs7176339; rs12443183; rs8029452; rs17266192; rs11630750; rs7496244; rs7181198; rs7166628; rs898585; rs967564; rs3784337; rs6494744; rs1470415; rs4426302; rs7176148; rs1445024; rs12915814; rs733574; rs3084584; rs12591263; rs34645431; rs28675010; rs1106706; rs28832076; rs12912332; rs28820967; rs34407903; rs28632038; rs33910742; rs34456821; rs1237911; rs4363820; rs11072017; rs2100003; rs1239019; rs16951868; rs35452602; rs4318156; rs28479079; rs35079218; rs8023993; rs11858232; rs34701287; rs8038774; rs28430608; rs28497433; rs34739598; rs35400299; rs11855056; rs10580084; rs12595520; rs11274413; rs7165603; rs10647873; rs4776401; rs9672383; rs8029186; rs35400442; rs34098259; rs2415004; rs34583165; rs28685790; rs11858237; rs11438057; rs28453743; rs4567653; rs1460643; rs28493712; rs28469639; rs34781411; rs5813485; rs10584732; rs10584731; rs34351994; rs35139299; rs35688044; rs5813489; rs12441591; rs8024015; rs35562050; rs13329519; rs34470974; rs35619732; rs3084640; rs34903160; rs34360809; rs34899976; rs28415078; rs33913338; rs5813482; rs34637773; rs11072007; rs8028080; rs11632946; rs35860391; rs4238413; rs35808090; rs8040548; rs28584322; rs7169698; rs28449432; rs898578; rs28620930; rs1077732; rs8028747; rs34800998; rs28517670; rs35874078; rs7164238; rs36078545; rs3084639; rs35280222; rs35325204; rs5813486; rs2271729; rs34438637; rs34704980; rs10574703; rs4777044; rs34297295; rs28669764; rs34222567; rs28695547; rs34278524; rs3084641; rs35584050; rs10618087; rs16952015; rs1542474; rs34822014; rs28740972; rs6494739; rs12591448; rs8032290; rs5813483; rs12898972; rs7174384; rs28442582; rs12902013; rs36216483; rs11858258; rs34660674; rs11632959; rs34338447; rs4777043; rs10565230; rs3837691; rs11858261; rs1824479; rs11854515; rs898591; rs16952019; rs28884935; rs34559605; rs2271727; rs34726895; rs28634234; rs35970041; rs898595; rs11072006; rs34588195; rs12593835; rs28434753; rs10580840; rs28522005; rs8029011; rs16951779; rs6494741; rs34224367; rs34119426; rs12914851; rs12442960; rs11424476; rs11428988; rs28401309; rs12912832; rs2084033; rs34918989; rs35499724; rs12899284; rs7181259; rs28665430; rs35325769; rs6145615; rs34136572; rs28363966; rs11638124; rs28394587; rs34001731; rs1870646; rs34840804; rs5813492; rs5813488; rs35178663; rs2414999; rs28711817; rs9630432; rs28713626; rs1996361; rs35284300; rs11380346; rs16951820; rs33914028; rs28436003; rs5813487; rs4533222; rs35094508; rs35035217; rs3837690; rs12441877; rs28768146; rs34640987; rs35071996; rs35051383; rs28672317; rs34079664; rs28491879; rs11072005; rs28735807; rs28613431; rs12050550; rs3084605; rs28723505; rs9672395; rs12593553; rs35634579; rs11853861; rs35666288; rs10569599; rs35025145; rs35900942; rs28591120; rs34501075; rs11855108; rs12592187; rs36096585; rs3084602; rs16952017; rs28461989; rs28460512; rs35426923; rs35952951; rs28566900; rs10567819; rs4402499; rs34030877; rs34618079; rs5813491; rs7177709; rs898588; rs28404208; rs7174690; rs35904581; rs12593571; rs4517738; rs28480552; rs34220669; rs35455543; rs28592619; rs36112980; rs34122553; rs7177979; rs5813484; rs34788905; rs12908869; rs35563812; rs28683053; rs34467259; rs34009804; rs10444850; rs11072002; rs11072003; rs11072004; rs11072022; rs11072025; rs12438807; rs12442355; rs12593610; rs12593620; rs12593625; rs12593626; rs12593634; rs12594282; rs12595056; rs12899005; rs12904888; rs12906388; rs12913105; rs12913467; rs12913696; rs12914614; rs1373699; rs1445022; rs1445023; rs2415015; rs2415016; rs2415017; rs2415018; rs28452190; rs2899738; rs34702468; rs35906516; rs4280184; rs4410025; rs4999936; rs4999937; rs6494730; rs6494745; rs7162348; rs7163188; rs7167102; rs7167465; rs7168990; rs7172173; rs7172500; rs8043066; rs8043202; rs920922; rs920923; rs920924

# Macromolecular_Interacting_Partner_65_General_References:
10486209; 10464311

# Macromolecular_Interacting_Partner_65_References:
16940330; 16973695

# Macromolecular_Interacting_Partner_66_ID:
8117

# Macromolecular_Interacting_Partner_66_Name:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

# Macromolecular_Interacting_Partner_66_Synonyms:
Brain cyclic nucleotide-gated channel 2; BCNG-2

# Macromolecular_Interacting_Partner_66_Gene_Name:
HCN2

# Macromolecular_Interacting_Partner_66_Protein_Sequence:
>Potassium/sodium hyperpolarizationactivated cyclic nucleotidegated channel 2
MDARGGGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEA
LPPEAADEGGPRGRLRSRDSSCGRPGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARG
PKVSFSCRGAASGPAPGPGPAEEAGSEEAGPAGEPRGSQASFMQRQFGALLQPGVNKFSL
RMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDET
TAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIP
VDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDL
ASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFALFK
AMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKY
KQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVA
SMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMK
LSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRL
DRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPP
PQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPPASP
PGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQPSLPHGAPGPAASTRP
ASSSTPRLGPTPAARAAAPSPDRRDSASPGAAGGLDPQDSARSRLSSNL

# Macromolecular_Interacting_Partner_66_Number_of_Residues:
889

# Macromolecular_Interacting_Partner_66_Molecular_Weight:
96951

# Macromolecular_Interacting_Partner_66_Theoretical_pI:
9.21

# Macromolecular_Interacting_Partner_66_GO_Classification:
>>>
Function:  transporter activity
Function:  ion transporter activity
Function:  ion channel activity
Function:  voltage-gated ion channel activity
Function:  voltage-gated potassium channel activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  cation transport
Process:  monovalent inorganic cation transport
Process:  potassium ion transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_66_General_Function:
Signal transduction mechanisms 

# Macromolecular_Interacting_Partner_66_Specific_Function:
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages

# Macromolecular_Interacting_Partner_66_Pathway:
Not Available

# Macromolecular_Interacting_Partner_66_Reaction:
Not Available

# Macromolecular_Interacting_Partner_66_Pfam_Domain_Function:
PF00027:cNMP_binding;
PF00520:Ion_trans;
PF08412:Ion_trans_N

# Macromolecular_Interacting_Partner_66_Signals:
None

# Macromolecular_Interacting_Partner_66_Transmembrane_Regions:
216-236
241-261
289-309
318-338
370-390
414-435
441-461

# Macromolecular_Interacting_Partner_66_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_66_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_66_GenBank_ID_Protein:
4996894

# Macromolecular_Interacting_Partner_66_SwissProt_ID:
HCN2_HUMAN (Q9UL51)

# Macromolecular_Interacting_Partner_66_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_66_Genecard_id:
HCN2

# Macromolecular_Interacting_Partner_66_Geneatlas_id:
HCN2

# Macromolecular_Interacting_Partner_66_hgnc_id:
HGNC:4846

# Macromolecular_Interacting_Partner_66_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_66_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_66_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_66_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_66_Gene_Sequence:
>2670 bp
ATGGACGCGCGCGGGGGCGGCGGGCGGCCCGGGGAGAGCCCGGGCGCGAGCCCCACGACC
GGGCCGCCGCCGCCGCCGCCCCCGCGCCCCCCCAAACAGCAGCCGCCGCCGCCGCCGCCG
CCCGCGCCCCCCCCGGGCCCCGGGCCCGCGCCCCCCCAGCACCCGCCCCGGGCCGAGGCG
TTGCCCCCGGAGGCGGCGGATGAGGGCGGCCCGCGGGGCCGGCTCCGCAGCCGCGACAGC
TCGTGCGGCCGCCCCGGCACCCCGGGCGCGGCGAGCACGGCCAAGGGCAGCCCGAACGGC
GAGTGCGGGCGCGGCGAGCCGCAGTGCAGCCCCGCGGGGCCCGAGGGCCCGGCGCGGGGG
CCCAAGGTGTCGTTCTCGTGCCGCGGGGCGGCCTCGGGGCCCGCGCCGGGGCCGGGGCCG
GCGGAGGAGGCGGGCAGCGAGGAGGCGGGCCCGGCGGGGGAGCCGCGCGGCAGCCAGGCC
AGCTTCATGCAGCGCCAGTTCGGCGCGCTCCTGCAGCCGGGCGTCAACAAGTTCTCGCTG
CGGATGTTCGGCAGCCAGAAGGCCGTGGAGCGCGAGCAGGAGCGCGTCAAGTCGGCGGGG
GCCTGGATCATCCACCCGTACAGCGACTTCAGGTTCTACTGGGACTTCACCATGCTGCTG
TTCATGGTGGGAAACCTCATCATCATCCCAGTGGGCATCACCTTCTTCAAGGATGAGACC
ACTGCCCCGTGGATCGTGTTCAACGTGGTCTCGGACACCTTCTTCCTCATGGACCTGGTG
TTGAACTTCCGCACCGGCATTGTGATCGAGGACAACACGGAGATCATCCTGGACCCCGAG
AAGATCAAGAAGAAGTATCTGCGCACGTGGTTCGTGGTGGACTTCGTGTCCTCCATCCCC
GTGGACTACATCTTCCTTATCGTGGAGAAGGGCATTGACTCCGAGGTCTACAAGACGGCA
CGCGCCCTGCGCATCGTGCGCTTCACCAAGATCCTCAGCCTCCTGCGGCTGCTGCGCCTC
TCACGCCTGATCCGCTACATCCATCAGTGGGAGGAGATCTTCCACATGACCTATGACCTG
GCCAGCGCGGTGATGAGGATCTGCAATCTCATCAGCATGATGCTGCTGCTCTGCCACTGG
GACGGCTGCCTGCAGTTCCTGGTGCCTATGCTGCAGGACTTCCCGCGCAACTGCTGGGTG
TCCATCAATGGCATGGTGAACCACTCGTGGAGTGAACTGTACTCCTTCGCACTCTTCAAG
GCCATGAGCCACATGCTGTGCATCGGGTACGGCCGGCAGGCGCCCGAGAGCATGACGGAC
ATCTGGCTGACCATGCTCAGCATGATTGTGGGTGCCACCTGCTACGCCATGTTCATCGGC
CACGCCACTGCCCTCATCCAGTCGCTGGACTCCTCGCGGCGCCAGTACCAGGAGAAGTAC
AAGCAGGTGGAGCAGTACATGTCCTTCCACAAGCTGCCAGCTGACTTCCGCCAGAAGATC
CACGACTACTATGAGCACCGTTACCAGGGCAAGATGTTTGACGAGGACAGCATCCTGGGC
GAGCTCAACGGGCCCCTGCGGGAGGAGATCGTCAACTTCAACTGCCGGAAGCTGGTGGCC
TCCATGCCGCTGTTCGCCAACGCCGACCCCAACTTCGTCACGGCCATGCTGACCAAGCTC
AAGTTCGAGGTCTTCCAGCCGGGTGACTACATCATCCGCGAAGGCACCATCGGGAAGAAG
ATGTACTTCATCCAGCACGGCGTGGTCAGCGTGCTCACTAAGGGCAACAAGGAGATGAAG
CTGTCCGATGGCTCCTACTTCGGGGAGATCTGCCTGCTCACCCGGGGCCGCCGCACGGCG
AGCGTGCGGGCTGACACCTACTGCCGCCTCTATTCGCTGAGCGTGGACAACTTCAACGAG
GTGCTGGAGGAGTACCCCATGATGCGGCGCGCCTTCGAGACGGTGGCCATCGACCGCCTG
GACCGCATCGGCAAGAAGAATTCCATCCTCCTGCACAAGGTGCAGCATGACCTCAACTCG
GGCGTATTCAACAACCAGGAGAACGCCATCATCCAGGAGATCGTCAAGTACGACCGCGAG
ATGGTGCAGCAGGCCGAGCTGGGTCAGCGCGTGGGCCTCTTCCCGCCGCCGCCGCCGCCG
CCGCAGGTCACCTCGGCCATCGCCACGCTGCAGCAGGCGGCGGCCATGAGCTTCTGCCCG
CAGGTGGCGCGGCCGCTCGTGGGGCCGCTGGCGCTCGGCTCGCCGCGCCTCGTGCGCCGC
CCGCCCCCGGGGCCCGCACCTGCCGCCGCCTCACCCGGGCCCCCGCCCCCCGCCAGCCCC
CCGGGCGCGCCCGCCAGCCCCCGGGCACCGCGGACCTCGCCCTACGGCGGCCTGCCCGCC
GCCCCCCTTGCTGGGCCCGCCCTGCCCGCGCGCCGCCTGAGCCGCGCGTCGCGCCCACTG
TCCGCCTCGCAGCCCTCGCTGCCTCACGGCGCCCCCGGCCCCGCGGCCTCCACACGCCCG
GCCAGCAGCTCCACACCGCGCTTGGGGCCCACGCCCGCTGCCCGGGCCGCCGCGCCCAGC
CCGGACCGCAGGGACTCGGCCTCACCCGGCGCCGCCGGCGGCCTGGACCCCCAGGACTCC
GCGCGCTCGCGCCTCTCGTCCAACTTGTGA

# Macromolecular_Interacting_Partner_66_GenBank_ID_Gene:
AF065164

# Macromolecular_Interacting_Partner_66_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_66_Locus:
19p13.3

# Macromolecular_Interacting_Partner_66_SNPs:
rs3752158; rs2301778; rs1054786; rs3829666; rs7255568; rs10408159; rs3852908; rs7508140; rs11878713; rs11085144; rs7252916; rs4591280; rs4473315; rs7507237; rs4919813; rs11085139; rs11085143; rs4398207; rs4919872; rs4558525; rs7508139; rs10403485; rs7508468; rs7253082; rs11669519; rs10413977; rs10419399; rs10853988; rs10422975; rs11668177; rs4919815; rs2392750; rs12463112; rs12462928; rs11881729; rs7258209; rs10410534; rs11881704; rs11879552; rs7257969; rs9304923; rs12977194; rs10419650; rs12462925; rs10424455; rs11882708; rs7246520; rs11882728; rs7245791; rs9284435; rs7246270; rs11669620; rs10424225; rs11085145; rs12460409; rs4555275; rs7508326; rs11883347; rs7255310; rs9677027; rs10404628; rs4555276; rs873634; rs10422590; rs3814894; rs11085129; rs7507720; rs11880461; rs11882870; rs3814895; rs11880490; rs34397648; rs12981860; rs11666355; rs11085137; rs12977789; rs10409425; rs28406180; rs10410763; rs12976859; rs11348294; rs35257813; rs7252580; rs34156384; rs28409415; rs12973933; rs12610632; rs12461820; rs11085136; rs7252617; rs4919865; rs12972945; rs35492782; rs12975101; rs12976597; rs35502309; rs34485160; rs7256665; rs12982875; rs34505785; rs34321099; rs3752159; rs7245910; rs34769108; rs9677028; rs35771564; rs35470668; rs9284436; rs34861460; rs12973449; rs34793549; rs11881589; rs4919814; rs12974196; rs4411625; rs11881654; rs12982612; rs35582889; rs12973917; rs34290852; rs34964734; rs12981115; rs35413122; rs12973067; rs12974341; rs10415299; rs11879835; rs12974871; rs11673232; rs10410547; rs35328198; rs11879834; rs28631088; rs36092405; rs34167478; rs28580097; rs12980903; rs10401400; rs34623818; rs12978322; rs7259120; rs35874491; rs12973177; rs10410787; rs12980310; rs10426120; rs11880636; rs34225996; rs11882745; rs12981107; rs7258226; rs10405282; rs11666354; rs12980894; rs36024888; rs12982197; rs28413822; rs34024843; rs34104611; rs8105172; rs12983110; rs35208581; rs7254986; rs12459773; rs3852909; rs4919866; rs34059313; rs7250810; rs9749564; rs7251793; rs10416161; rs10409268; rs11666936; rs7251301; rs34005821; rs34980846; rs3829959; rs34118035; rs11278787; rs3842700; rs34144639; rs35775177; rs41551212; rs10407135; rs10416339; rs1049676; rs1054794; rs1063376; rs1063378; rs10853989; rs10853990; rs11473; rs11669141; rs11669180; rs11669381; rs11672829; rs11879069; rs12609750; rs12609751; rs12611055; rs13235; rs13676; rs1803203; rs1803535; rs1804752; rs2017580; rs2041192; rs2072122; rs2072309; rs2072310; rs2074548; rs2074962; rs2108832; rs2238546; rs2238548; rs2238549; rs2238550; rs2285853; rs2285854; rs2285855; rs3189749; rs34830716; rs35926953; rs3764937; rs3764938; rs3815110; rs4682; rs4919812; rs4919862; rs4919864; rs6758; rs8102843; rs8259; rs8637

# Macromolecular_Interacting_Partner_66_General_References:
10524219; 10228147; 9630217

# Macromolecular_Interacting_Partner_66_References:
16617177; 16882011; 17038640

# Macromolecular_Interacting_Partner_67_ID:
8546

# Macromolecular_Interacting_Partner_67_Name:
Multidrug resistance-associated protein 5

# Macromolecular_Interacting_Partner_67_Synonyms:
ATP-binding cassette sub- family C member 5; Multi-specific organic anion transporter-C; MOAT- C; pABC11; SMRP

# Macromolecular_Interacting_Partner_67_Gene_Name:
ABCC5

# Macromolecular_Interacting_Partner_67_Protein_Sequence:
>Multidrug resistanceassociated protein 5
MKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLS
LDASMHSQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLAR
VAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLI
LSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTW
ALNYRTGVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGG
PVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNE
VLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSV
HMTLGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIK
NKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQA
VLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSG
KTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNS
CCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVG
NHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATI
FNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGS
VPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETS
VSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPM
KFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGP
LVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQEL
LDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT
GLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEM
RYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISD
IGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLE
SEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCT
MLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKVAVKG

# Macromolecular_Interacting_Partner_67_Number_of_Residues:
1437

# Macromolecular_Interacting_Partner_67_Molecular_Weight:
160663

# Macromolecular_Interacting_Partner_67_Theoretical_pI:
8.89

# Macromolecular_Interacting_Partner_67_GO_Classification:
>>>
 Function:  ATPase activity
Function:  hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Function:  ATPase activity, coupled to transmembrane movement of substances
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_67_General_Function:
Defense mechanisms

# Macromolecular_Interacting_Partner_67_Specific_Function:
Acts as a multispecific organic anion pump which can transport nucleotide analogs

# Macromolecular_Interacting_Partner_67_Pathway:
Not Available

# Macromolecular_Interacting_Partner_67_Reaction:
Not Available

# Macromolecular_Interacting_Partner_67_Pfam_Domain_Function:
PF00664:ABC_membrane
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_67_Signals:
1-874

# Macromolecular_Interacting_Partner_67_Transmembrane_Regions:
179-199
219-239
296-316
317-337
400-420
434-454
608-628
848-868
917-937
997-1017
1018-1038
1104-1124
1127-1147

# Macromolecular_Interacting_Partner_67_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_67_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_67_GenBank_ID_Protein:
4140698

# Macromolecular_Interacting_Partner_67_SwissProt_ID:
MRP5_HUMAN (O15440)

# Macromolecular_Interacting_Partner_67_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_67_Genecard_id:
ABCC5

# Macromolecular_Interacting_Partner_67_Geneatlas_id:
ABCC5

# Macromolecular_Interacting_Partner_67_hgnc_id:
HGNC:56

# Macromolecular_Interacting_Partner_67_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_67_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_67_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_67_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_67_Gene_Sequence:
>4314 bp
ATGAAGGATATCGACATAGGAAAAGAGTATATCATCCCCAGTCCTGGGTATAGAAGTGTG
AGGGAGAGAACCAGCACTTCTGGGACGCACAGAGACCGTGAAGATTCCAAGTTCAGGAGA
ACTCGACCGTTGGAATGCCAAGATGCCTTGGAAACAGCAGCCCGAGCCGAGGGCCTCTCT
CTTGATGCCTCCATGCATTCTCAGCTCAGAATCCTGGATGAGGAGCATCCCAAGGGAAAG
TACCATCATGGCTTGAGTGCTCTGAAGCCCATCCGGACTACTTCCAAACACCAGCACCCA
GTGGACAATGCTGGGCTTTTTTCCTGTATGACTTTTTCGTGGCTTTCTTCTCTGGCCCGT
GTGGCCCACAAGAAGGGGGAGCTCTCAATGGAAGACGTGTGGTCTCTGTCCAAGCACGAG
TCTTCTGACGTGAACTGCAGAAGACTAGAGAGACTGTGGCAAGAAGAGCTGAATGAAGTT
GGGCCAGACGCTGCTTCCCTGCGAAGGGTTGTGTGGATCTTCTGCCGCACCAGGCTCATC
CTGTCCATCGTGTGCCTGATGATCACGCAGCTGGCTGGCTTCAGTGGACCAGCCTTCATG
GTGAAACACCTCTTGGAGTATACCCAGGCAACAGAGTCTAACCTGCAGTACAGCTTGTTG
TTAGTGCTGGGCCTCCTCCTGACGGAAATCGTGCGGTCTTGGTCGCTTGCACTGACTTGG
GCATTGAATTACCGAACCGGTGTCCGCTTGCGGGGGGCCATCCTAACCATGGCATTTAAG
AAGATCCTTAAGTTAAAGAACATTAAAGAGAAATCCCTGGGTGAGCTCATCAACATTTGC
TCCAACGATGGGCAGAGAATGTTTGAGGCAGCAGCCGTTGGCAGCCTGCTGGCTGGAGGA
CCCGTTGTTGCCATCTTAGGCATGATTTATAATGTAATTATTCTGGGACCAACAGGCTTC
CTGGGATCAGCTGTTTTTATCCTCTTTTACCCAGCAATGATGTTTGCATCACGGCTCACA
GCATATTTCAGGAGAAAATGCGTGGCCGCCACGGATGAACGTGTCCAGAAGATGAATGAA
GTTCTTACTTACATTAAATTTATCAAAATGTATGCCTGGGTCAAAGCATTTTCTCAGAGT
GTTCAAAAAATCCGCGAGGAGGAGCGTCGGATATTGGAAAAAGCCGGGTACTTCCAGGGT
ATCACTGTGGGTGTGGCTCCCATTGTGGTGGTGATTGCCAGCGTGGTGACCTTCTCTGTT
CATATGACCCTGGGCTTCGATCTGACAGCAGCACAGGCTTTCACAGTGGTGACAGTCTTC
AATTCCATGACTTTTGCTTTGAAAGTAACACCGTTTTCAGTAAAGTCCCTCTCAGAAGCC
TCAGTGGCTGTTGACAGATTTAAGAGTTTGTTTCTAATGGAAGAGGTTCACATGATAAAG
AACAAACCAGCCAGTCCTCACATCAAGATAGAGATGAAAAATGCCACCTTGGCATGGGAC
TCCTCCCACTCCAGTATCCAGAACTCGCCCAAGCTGACCCCCAAAATGAAAAAAGACAAG
AGGGCTTCCAGGGGCAAGAAAGAGAAGGTGAGGCAGCTGCAGCGCACTGAGCATCAGGCG
GTGCTGGCAGAGCAGAAAGGCCACCTCCTCCTGGACAGTGACGAGCGGCCCAGTCCCGAA
GAGGAAGAAGGCAAGCACATCCACCTGGGCCACCTGCGCTTACAGAGGACACTGCACAGC
ATCGATCTGGAGATCCAAGAGGGTAAACTGGTTGGAATCTGCGGCAGTGTGGGAAGTGGA
AAAACCTCTCTCATTTCAGCCATTTTAGGCCAGATGACGCTTCTAGAGGGCAGCATTGCA
ATCAGTGGAACCTTCGCTTATGTGGCCCAGCAGGCCTGGATCCTCAATGCTACTCTGAGA
GACAACATCCTGTTTGGGAAGGAATATGATGAAGAAAGATACAACTCTGTGCTGAACAGC
TGCTGCCTGAGGCCTGACCTGGCCATTCTTCCCAGCAGCGACCTGACGGAGATTGGAGAG
CGAGGAGCCAACCTGAGCGGTGGGCAGCGCCAGAGGATCAGCCTTGCCCGGGCCTTGTAT
AGTGACAGGAGCATCTACATCCTGGACGACCCCCTCAGTGCCTTAGATGCCCATGTGGGC
AACCACATCTTCAATAGTGCTATCCGGAAACATCTCAAGTCCAAGACAGTTCTGTTTGTT
ACCCACCAGTTACAGTACCTGGTTGACTGTGATGAAGTGATCTTCATGAAAGAGGGCTGT
ATTACGGAAAGAGGCACCCATGAGGAACTGATGAATTTAAATGGTGACTATGCTACCATT
TTTAATAACCTGTTGCTGGGAGAGACACCGCCAGTTGAGATCAATTCAAAAAAGGAAACC
AGTGGTTCACAGAAGAAGTCACAAGACAAGGGTCCTAAAACAGGATCAGTAAAGAAGGAA
AAAGCAGTAAAGCCAGAGGAAGGGCAGCTTGTGCAGCTGGAAGAGAAAGGGCAGGGTTCA
GTGCCCTGGTCAGTATATGGTGTCTACATCCAGGCTGCTGGGGGCCCCTTGGCATTCCTG
GTTATTATGGCCCTTTTCATGCTGAATGTAGGCAGCACCGCCTTCAGCACCTGGTGGTTG
AGTTACTGGATCAAGCAAGGAAGCGGGAACACCACTGTGACTCGAGGGAACGAGACCTCG
GTGAGTGACAGCATGAAGGACAATCCTCATATGCAGTACTATGCCAGCATCTACGCCCTC
TCCATGGCAGTCATGCTGATCCTGAAAGCCATTCGAGGAGTTGTCTTTGTCAAGGGCACG
CTGCGAGCTTCCTCCCGGCTGCATGACGAGCTTTTCCGAAGGATCCTTCGAAGCCCTATG
AAGTTTTTTGACACGACCCCCACAGGGAGGATTCTCAACAGGTTTTCCAAAGACATGGAT
GAAGTTGACGTGCGGCTGCCGTTCCAGGCCGAGATGTTCATCCAGAACGTTATCCTGGTG
TTCTTCTGTGTGGGAATGATCGCAGGAGTCTTCCCGTGGTTCCTTGTGGCAGTGGGGCCC
CTTGTCATCCTCTTTTCAGTCCTGCACATTGTCTCCAGGGTCCTGATTCGGGAGCTGAAG
CGTCTGGACAATATCACGCAGTCACCTTTCCTCTCCCACATCACGTCCAGCATACAGGGC
CTTGCCACCATCCACGCCTACAATAAAGGGCAGGAGTTTCTGCACAGATACCAGGAGCTG
CTGGATGACAACCAAGCTCCTTTTTTTTTGTTTACGTGTGCGATGCGGTGGCTGGCTGTG
CGGCTGGACCTCATCAGCATCGCCCTCATCACCACCACGGGGCTGATGATCGTTCTTATG
CACGGGCAGATTCCCCCAGCCTATGCGGGTCTCGCCATCTCTTATGCTGTCCAGTTAACG
GGGCTGTTCCAGTTTACGGTCAGACTGGCATCTGAGACAGAAGCTCGATTCACCTCGGTG
GAGAGGATCAATCACTACATTAAGACTCTGTCCTTGGAAGCACCTGCCAGAATTAAGAAC
AAGGCTCCCTCCCCTGACTGGCCCCAGGAGGGAGAGGTGACCTTTGAGAACGCAGAGATG
AGGTACCGAGAAAACCTCCCTCTTGTCCTAAAGAAAGTATCCTTCACGATCAAACCTAAA
GAGAAGATTGGCATTGTGGGGCGGACAGGATCAGGGAAGTCCTCGCTGGGGATGGCCCTC
TTCCGTCTGGTGGAGTTATCTGGAGGCTGCATCAAGATTGATGGAGTGAGAATCAGTGAT
ATTGGCCTTGCCGACCTCCGAAGCAAACTCTCTATCATTCCTCAAGAGCCGGTGCTGTTC
AGTGGCACTGTCAGATCAAATTTGGACCCCTTCAACCAGTACACTGAAGACCAGATTTGG
GATGCCCTGGAGAGGACACACATGAAAGAATGTATTGCTCAGCTACCTCTGAAACTTGAA
TCTGAAGTGATGGAGAATGGGGATAACTTCTCAGTGGGGGAACGGCAGCTCTTGTGCATA
GCTAGAGCCCTGCTCCGCCACTGTAAGATTCTGATTTTAGATGAAGCCACAGCTGCCATG
GACACAGAGACAGACTTATTGATTCAAGAGACCATCCGAGAAGCATTTGCAGACTGTACC
ATGCTGACCATTGCCCATCGCCTGCACACGGTTCTAGGCTCCGATAGGATTATGGTGCTG
GCCCAGGGACAGGTGGTGGAGTTTGACACCCCATCGGTCCTTCTGTCCAACGACAGTTCC
CGATTCTATGCCATGTTTGCTGCTGCAGAGAACAAGGTCGCTGTCAAGGGCTGA

# Macromolecular_Interacting_Partner_67_GenBank_ID_Gene:
AF104942

# Macromolecular_Interacting_Partner_67_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_67_Locus:
3q27

# Macromolecular_Interacting_Partner_67_SNPs:
rs939336; rs1132776; rs3749442; rs7636910; rs1053386; rs4148575; rs562; rs4148557; rs7610724; rs9869029; rs3805114; rs3749440; rs3749445; rs3749444; rs1879257; rs2313212; rs2139564; rs1401999; rs1402003; rs2292998; rs1016752; rs939338; rs12634398; rs6806313; rs3828469; rs1879258; rs3817403; rs4148578; rs6790814; rs2292997; rs4148585; rs9876143; rs1402001; rs4148563; rs4148571; rs2293001; rs6443928; rs6804242; rs1554395; rs6775518; rs4148577; rs7646621; rs3749438; rs2292999; rs2872247; rs9840067; rs4148567; rs4148561; rs2271937; rs2271936; rs4912515; rs10937157; rs869417; rs13317532; rs4074672; rs4148579; rs4148564; rs939337; rs2293000; rs6773408; rs6802849; rs4912517; rs6443927; rs11926347; rs12638017; rs4148562; rs1879259; rs7610680; rs4148581; rs2139559; rs4148594; rs1402002; rs3792585; rs3805112; rs11924260; rs9838667; rs9861983; rs2037379; rs4148584; rs10937156; rs6766526; rs16858271; rs4912471; rs7620350; rs3792582; rs3805108; rs6766401; rs4148587; rs9290779; rs11925478; rs9812777; rs6773404; rs9858774; rs9818518; rs6797914; rs16858273; rs4148586; rs16858289; rs11927192; rs3792581; rs4148589; rs6443925; rs3749441; rs4148593; rs17817736; rs3792583; rs3817404; rs7635948; rs2176824; rs4148591; rs16858269; rs6443923; rs7644017; rs869335; rs3792586; rs4148559; rs12054261; rs9870759; rs35296517; rs4148568; rs6800415; rs4148576; rs6800217; rs12630716; rs6799583; rs2139560; rs16858293; rs12495544; rs10937158; rs7632824; rs3805109; rs2280392; rs17218330; rs7636305; rs4148569; rs6795595; rs6791345; rs11711546; rs6788699; rs11926189; rs6767013; rs7624838; rs2271939; rs8180093; rs3805111; rs11718755; rs13326378; rs9917823; rs13323062; rs16858328; rs6443926; rs4912514; rs4148560; rs4148570; rs9880007; rs6767306; rs7632670; rs13093614; rs7620781; rs9290778; rs3749443; rs4148573; rs17217796; rs1464322; rs3805107; rs9840799; rs6443924; rs4148572; rs11714326; rs3792584; rs11708244; rs6805913; rs13434094; rs6443922; rs11718456; rs13326374; rs4148580; rs4148590; rs11924558; rs1000002; rs2872249; rs6768149; rs1533684; rs2313217; rs1520195; rs2313215; rs7627754; rs2313216; rs7647281; rs11552530; rs1053351; rs11708427; rs1053387; rs41313430; rs4148595; rs13325143; rs1801744; rs4148556; rs35543804; rs7643273; rs9811001; rs11552529; rs3779; rs34652026; rs4148558; rs11458384; rs34788375; rs12053949; rs13077293; rs36109619; rs34041300; rs11404217; rs35406204; rs36008544; rs11304498; rs10663124; rs35014671; rs28484985; rs11364435; rs2176826; rs34965144; rs10572862; rs36062087; rs4148592; rs34080554; rs35280205; rs34465032; rs34269031; rs4148565; rs35596251; rs34821185; rs11289102; rs34023806; rs34319740; rs35768238; rs28757633; rs7610358; rs11340231; rs11438378; rs34811300; rs35613074; rs13323064; rs28680881; rs35637952; rs36099101; rs13097299; rs35740940; rs4148588; rs13323043; rs4572819; rs3828467; rs35696927; rs11287890; rs13078856; rs34820361; rs9876269; rs34672768; rs35240483; rs35273379; rs34341315; rs34764294; rs12185910; rs7613962; rs13063947; rs35693341; rs36063744; rs4148566; rs34025610; rs34915309; rs34470092; rs6769040; rs41266245; rs12630719; rs3031485; rs10654680; rs34420545; rs11298066; rs9880975; rs11429616; rs35072046; rs3840256; rs34672752; rs9833037; rs10715407; rs34465853; rs4148574; rs34054908; rs34892836; rs10575785; rs35475544; rs10530539; rs34235232; rs36028898; rs13097656; rs35912087; rs35945591; rs34792181; rs35961047; rs41266247; rs35849988; rs35621685; rs3840257; rs2139562; rs4530573; rs10576500; rs5855009; rs13097142; rs9832380; rs13064234; rs35402378; rs34431093; rs4912516; rs2010085; rs35562213; rs13077104; rs953849; rs7429794; rs10541470; rs34905378; rs34643197; rs7637515; rs35242282; rs35014056; rs2139561; rs34571027; rs10670556; rs5855008; rs34375406; rs11350186; rs28670026; rs11429168; rs7633894; rs2037378; rs12493172; rs6807429; rs35034391; rs7621683; rs6766986; rs13097932; rs34598299; rs9882081; rs34751392; rs34714693; rs28695172; rs11711790; rs11437128; rs12633449; rs10460893; rs35158514; rs41289067; rs11389779; rs28618373; rs13077275; rs11328470; rs11328697; rs12631110; rs11918185; rs35710369; rs36089749; rs35727968; rs34234737; rs34167032; rs6791247; rs10584632; rs11716770; rs11720137; rs11926572; rs12638772; rs13066518; rs1533682; rs1533683; rs2176825; rs2313211; rs28365007; rs28365013; rs28365016; rs28365027; rs2872250; rs34874825; rs35477410; rs35561263; rs35843033; rs6810123; rs7613237; rs7613247; rs7625464; rs7646967; rs7651256; rs939335; rs9881873

# Macromolecular_Interacting_Partner_67_General_References:
9827529; 10438534; 10721709; 10840050; 9325169; 9270026

# Macromolecular_Interacting_Partner_67_References:
Not Available

# Macromolecular_Interacting_Partner_68_ID:
8797

# Macromolecular_Interacting_Partner_68_Name:
Hypothetical protein PDE11A

# Macromolecular_Interacting_Partner_68_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_68_Gene_Name:
PDE11A

# Macromolecular_Interacting_Partner_68_Protein_Sequence:
>Hypothetical protein PDE11
AVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQT
LLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAEN

# Macromolecular_Interacting_Partner_68_Number_of_Residues:
98

# Macromolecular_Interacting_Partner_68_Molecular_Weight:
11231

# Macromolecular_Interacting_Partner_68_Theoretical_pI:
5.19

# Macromolecular_Interacting_Partner_68_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_68_General_Function:
Not Available

# Macromolecular_Interacting_Partner_68_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_68_Pathway:
Not Available

# Macromolecular_Interacting_Partner_68_Reaction:
Not Available

# Macromolecular_Interacting_Partner_68_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_68_Signals:
Not Available

# Macromolecular_Interacting_Partner_68_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_68_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_68_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_68_GenBank_ID_Protein:
62988743

# Macromolecular_Interacting_Partner_68_SwissProt_ID:
Q53S07_HUMAN (Q53S07)

# Macromolecular_Interacting_Partner_68_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_68_Genecard_id:
PDE11A

# Macromolecular_Interacting_Partner_68_Geneatlas_id:
PDE11A

# Macromolecular_Interacting_Partner_68_hgnc_id:
HGNC:8773

# Macromolecular_Interacting_Partner_68_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_68_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_68_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_68_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_68_Gene_Sequence:
>296 bp
GTTATGCAGATGTATCTTCCATTTTGTGGAATCGCCATATCTAACGCTCAGCTCTTTGCT
GCCTCAAGGAAAGAATATGAAAGAAGCAGAGCTTTGCTAGAGGTGGTTAATGACCTCTTT
GAAGAACAGACTGACCTGGAGAAAATTGTCAAGAAAATAATGCATCGGGCCCAAACTCTG
CTGAAATGTGAACGCTGTTCTGTTTTACTCCTAGAGGACATCGAATCACCAGTGGTGAAA
TTTACCAAATCCTTTGAATTGATGTCCCCAAAGTGCAGTGCTGATGCTGAGAACAG

# Macromolecular_Interacting_Partner_68_GenBank_ID_Gene:
AC073892

# Macromolecular_Interacting_Partner_68_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_68_Locus:
2q31.2

# Macromolecular_Interacting_Partner_68_SNPs:
rs6705405; rs6734426; rs6734528; rs6734683; rs13034886; rs13010396; rs1438035; rs966433; rs1852503; rs1866212; rs1561316; rs2573088; rs941271; rs2886498; rs2695743; rs2365889; rs1465830; rs1469973; rs1438046; rs1880916; rs2573082; rs1982131; rs934798; rs2695760; rs1370662; rs1347731; rs1561319; rs1405650; rs2252726; rs2695109; rs1438054; rs1546813; rs1405646; rs1469972; rs1358326; rs1997208; rs2695099; rs1527399; rs1438063; rs1821628; rs2164860; rs1527293; rs1997206; rs1358327; rs1997207; rs2573083; rs1534290; rs1544001; rs1405651; rs1370661; rs2695740; rs1004541; rs934809; rs2118482; rs1370656; rs2037757; rs1344925; rs744397; rs1405647; rs753346; rs2060490; rs1347441; rs959157; rs1438038; rs2222711; rs1344922; rs744398; rs934803; rs1405648; rs1438037; rs2695098; rs1438051; rs1534289; rs1438048; rs934802; rs3770044; rs10497478; rs9288011; rs1344923; rs10170290; rs2695757; rs3108476; rs2695115; rs7583817; rs1866211; rs1527294; rs1369519; rs2020213; rs12693147; rs4893844; rs1106074; rs6433694; rs4893975; rs10497483; rs2695735; rs2573087; rs3108453; rs3770034; rs714528; rs4893980; rs998059; rs7560514; rs4413189; rs2695097; rs3770009; rs2573079; rs2886499; rs10198681; rs6746845; rs7563242; rs7606084; rs6433691; rs6760930; rs10198111; rs7570423; rs3770023; rs6737254; rs2043546; rs6718702; rs7573755; rs1370663; rs1020010; rs1370658; rs6433705; rs2695738; rs6433708; rs1438064; rs2695741; rs7588973; rs6433698; rs6749088; rs1561320; rs7605493; rs1527292; rs1991994; rs13421315; rs4893994; rs6721360; rs7570981; rs6433710; rs7588062; rs2886651; rs2695728; rs3770045; rs7600368; rs11684634; rs3770051; rs3754996; rs7586934; rs7578325; rs1465831; rs7605091; rs13026481; rs6758442; rs12693133; rs10186239; rs3770007; rs7573622; rs9679090; rs10930820; rs1405649; rs2217839; rs1527410; rs12693128; rs5025340; rs6726321; rs13389574; rs3910519; rs7591796; rs1435573; rs4893839; rs7569984; rs1527400; rs6718860; rs2695104; rs6745743; rs2695756; rs1898012; rs4893840; rs6758543; rs1344916; rs1830209; rs1438039; rs6738614; rs1997209; rs2043548; rs1527291; rs10198877; rs3951527; rs6726477; rs1527401; rs7591897; rs6433695; rs941274; rs6734520; rs1866209; rs7598623; rs959792; rs1369520; rs13026012; rs7595479; rs1004542; rs1527407; rs9288009; rs2365895; rs2695724; rs13429220; rs4893972; rs4522644; rs2695746; rs7557283; rs10207459; rs7559765; rs6708869; rs2886424; rs1438040; rs6720891; rs1946814; rs6741976; rs6733229; rs6743821; rs7608073; rs1527295; rs12693151; rs1866210; rs6737872; rs6433693; rs6750238; rs10930814; rs13428806; rs6751656; rs3770003; rs934804; rs12693127; rs6760512; rs6433709; rs2573085; rs10174604; rs2033762; rs6718657; rs2695103; rs3770018; rs10497493; rs6745288; rs1530035; rs1435574; rs1438049; rs4893985; rs10192481; rs6757651; rs10201180; rs11887429; rs1527296; rs4335982; rs2695112; rs2222712; rs880899; rs13009350; rs2695091; rs12990719; rs3821010; rs1527405; rs7605757; rs10497482; rs13402629; rs16865524; rs10189134; rs10497485; rs17635934; rs2015183; rs3731809; rs2033763; rs12693148; rs2695111; rs1358328; rs732363; rs12468127; rs10221806; rs6756994; rs12616259; rs1438045; rs1898585; rs12693146; rs6705118; rs2099476; rs13412319; rs13431084; rs12619453; rs12612171; rs13017429; rs6740251; rs6714519; rs4893995; rs13008780; rs1975323; rs2886500; rs2366352; rs7594290; rs12693123; rs7575322; rs6716496; rs10497494; rs13426862; rs10221783; rs17400325; rs11695452; rs13386639; rs1816520; rs6433685; rs6729482; rs3770015; rs7578901; rs11889185; rs13028757; rs1317945; rs9808399; rs4144275; rs2365896; rs1405718; rs17329956; rs1530034; rs11674668; rs17400505; rs7584946; rs6724986; rs13034781; rs3770047; rs12693145; rs6759712; rs10497479; rs4468852; rs12612509; rs13030747; rs3821007; rs4893987; rs10930805; rs1370655; rs12994494; rs17635957; rs2695094; rs880898; rs13390014; rs2573080; rs6433688; rs2695730; rs11883602; rs3770016; rs13389525; rs16866032; rs7568068; rs4337505; rs13017473; rs934801; rs12475250; rs13025391; rs4423634; rs16865995; rs17401468; rs17330172; rs6433711; rs1405645; rs12693130; rs10497495; rs4144276; rs10754990; rs16865872; rs2033760; rs16865498; rs11677821; rs12478277; rs11904461; rs13396537; rs10168641; rs11886258; rs13427906; rs11680652; rs10175364; rs16865645; rs10164920; rs3770050; rs13402636; rs2695729; rs13022684; rs1527402; rs7560080; rs2033761; rs6752264; rs12618542; rs10190805; rs12618537; rs17636610; rs13003683; rs1469971; rs17401650; rs4893976; rs4893988; rs10497480; rs10201150; rs13032794; rs934800; rs10191328; rs11903134; rs880897; rs6705472; rs12471621; rs12987101; rs6753870; rs10178985; rs2365625; rs16865492; rs17400931; rs1866215; rs10165396; rs6759109; rs1547580; rs13411922; rs2695732; rs13426284; rs6752409; rs13405585; rs6756240; rs4541282; rs3731808; rs3770008; rs2365619; rs1561318; rs17329742; rs16865906; rs16865604; rs17635803; rs4567975; rs3770005; rs6709256; rs6717171; rs10202985; rs16865535; rs10180052; rs10174066; rs3754993; rs12693149; rs10497496; rs10497486; rs13427960; rs2366353; rs2695737; rs2164859; rs3108451; rs10194370; rs10171486; rs7422544; rs6433697; rs11892557; rs1865588; rs1438062; rs6733980; rs6746482; rs13392051; rs2695742; rs2091442; rs6739583; rs6750869; rs13419437; rs1527403; rs1866208; rs10197020; rs6726502; rs6433690; rs7422960; rs1547581; rs4893981; rs1898013; rs13429445; rs12612481; rs2164857; rs11686720; rs6712082; rs4243392; rs13410185; rs16866042; rs3770011; rs16865503; rs1837163; rs17329998; rs10211057; rs12151755; rs12613207; rs11679730; rs7604345; rs7591800; rs16865494; rs1358299; rs4470372; rs10497488; rs6736927; rs7567851; rs941276; rs9677333; rs7421260; rs10930809; rs6707034; rs10202989; rs3770048; rs934806; rs12693129; rs7597640; rs3915272; rs10208501; rs12693143; rs11678875; rs17400512; rs7588301; rs17687170; rs11687117; rs12616321; rs13025904; rs1821629; rs13008170; rs6715232; rs12995449; rs13425873; rs2695725; rs3770035; rs3770028; rs3821009; rs11680632; rs3770012; rs10192225; rs1837164; rs13015148; rs12618150; rs10170914; rs11896183; rs4893989; rs1527288; rs3770019; rs10172800; rs17401293; rs6704720; rs13017234; rs12693150; rs11904417; rs7562835; rs13386418; rs1946813; rs7559596; rs11690740; rs10175970; rs16865825; rs4341975; rs11687543; rs13009207; rs2886653; rs12463866; rs13017026; rs6755503; rs4893979; rs17401860; rs12693142; rs16865901; rs17402102; rs3821008; rs16865703; rs998060; rs7577552; rs6718206; rs10930815; rs10497487; rs13398310; rs4446096; rs12469388; rs2164858; rs11892483; rs7566399; rs6713981; rs1438060; rs4110134; rs17400121; rs6748696; rs3770053; rs13022805; rs7558310; rs12693131; rs3754991; rs7573345; rs7595951; rs10183144; rs10497492; rs2365620; rs10170607; rs7561059; rs10171247; rs1405716; rs1544003; rs749208; rs6718993; rs13398604; rs10197329; rs13003047; rs7593753; rs999218; rs1106075; rs10210259; rs3770010; rs1370657; rs6708025; rs1025598; rs12618596; rs1435575; rs12473461; rs934808; rs6709966; rs11674299; rs934799; rs959775; rs1370664; rs13000926; rs11893349; rs11883778; rs1544002; rs4893984; rs13411542; rs10497490; rs16865819; rs17330290; rs2117740; rs6756606; rs7579625; rs1554776; rs10497484; rs16865756; rs10191015; rs1405714; rs17401902; rs16866000; rs749207; rs7605744; rs4893847; rs11891283; rs12619506; rs2695092; rs13014883; rs2360221; rs17687590; rs12472886; rs13428032; rs10497491; rs2164330; rs13008833; rs13413095; rs1438036; rs1561317; rs17635875; rs1852497; rs13384920; rs13411527; rs6754385; rs12618606; rs6738831; rs9288008; rs2695726; rs13422276; rs13396065; rs10930817; rs13012431; rs7605609; rs13422706; rs1344917; rs934807; rs7596644; rs6724987; rs1852500; rs12693144; rs13411970; rs7570898; rs6433704; rs6739044; rs2009303; rs1898587; rs6433687; rs6727390; rs7592278; rs13395965; rs12994405; rs13002118; rs11899173; rs16865821; rs7609487; rs10186273; rs6758923; rs12620627; rs2365899; rs13034432; rs13419927; rs6750991; rs7584838; rs35625771; rs13427929; rs13006992; rs13427912; rs16865697; rs10165299; rs7598835; rs13427600; rs9808095; rs13422021; rs13429906; rs10930819; rs7420642; rs10169917; rs10168605; rs16865643; rs12474141; rs4893986; rs16865593; rs6734297; rs7595421; rs7424429; rs11884289; rs6721029; rs13394480; rs16865835; rs10930806; rs13007187; rs10178125; rs6724505; rs7598748; rs6758297; rs11695211; rs16865887; rs2365898; rs16865921; rs12478848; rs17330075; rs13008857; rs9283485; rs16865912; rs12477170; rs16865743; rs2695723; rs10165196; rs12151806; rs13014945; rs13391502; rs6716206; rs16865998; rs16865753; rs7558301; rs16865852; rs10192990; rs10181377; rs12611503; rs1438053; rs16865752; rs7577174; rs16865698; rs16865791; rs17400526; rs1975324; rs7574565; rs1534305; rs10181024; rs16866036; rs17400834; rs6747512; rs6433686; rs7577598; rs16865493; rs13010041; rs13410486; rs10183838; rs13021998; rs13021204; rs1918347; rs12105799; rs2695721; rs17330012; rs13392577; rs13007766; rs7569124; rs12988331; rs10200643; rs1595443; rs6737549; rs10202536; rs4508637; rs9288013; rs12465539; rs16865848; rs2695744; rs3770013; rs13004037; rs16866003; rs2365621; rs16865844; rs1898588; rs2695101; rs1975321; rs13393722; rs1986843; rs9679360; rs9646795; rs3754994; rs934569; rs4511758; rs6760949; rs4324348; rs10186678; rs10176232; rs7556748; rs6746962; rs12613904; rs12989020; rs2365618; rs16866031; rs2695720; rs13413635; rs10165192; rs16865933; rs13019660; rs3770043; rs7588304; rs2056715; rs7568082; rs12616288; rs9679242; rs3770014; rs16865642; rs4277559; rs16865772; rs7557136; rs13398395; rs12622125; rs9677101; rs13006098; rs10208589; rs4456736; rs13004202; rs6745398; rs6755382; rs7593744; rs6758473; rs11684363; rs2178018; rs1898589; rs10193299; rs10179500; rs13421432; rs13408518; rs13023939; rs13386827; rs13395151; rs10195518; rs10179821; rs1347730; rs16865748; rs13386657; rs1370660; rs6433700; rs6738098; rs12469884; rs16865706; rs7609350; rs7607094; rs2695747; rs16865850; rs12987515; rs6729216; rs10168715; rs17401951; rs12994913; rs10182150; rs2695752; rs13007759; rs1438055; rs11885059; rs13423503; rs6708449; rs7596360; rs10497477; rs16865527; rs10497489; rs4585066; rs1370659; rs1344924; rs10432481; rs11684953; rs10497481; rs12615564; rs16865651; rs10184562; rs11901841; rs10432482; rs3770036; rs1369518; rs2366354; rs13030321; rs11888049; rs16865771; rs1898590; rs941272; rs17329531; rs16865684; rs16865846; rs10165826; rs13014074; rs6747480; rs2695731; rs6761951; rs10168170; rs1946812; rs1866214; rs10930810; rs4893977; rs11694948; rs12612475; rs7423941; rs12990471; rs2695734; rs4893978; rs1438056; rs11682717; rs7570577; rs10176298; rs4893971; rs1547582; rs6731237; rs9653239; rs2695748; rs1527408; rs13421772; rs17636214; rs1344920; rs16865625; rs12467363; rs13384016; rs7557138; rs10211367; rs17329062; rs10469714; rs2695108; rs13018609; rs13408911; rs1949965; rs9679120; rs12475108; rs1527409; rs16865726; rs16865839; rs934567; rs13424417; rs7607529; rs1527406; rs10190199; rs3861373; rs1527290; rs10181136; rs10202419; rs10432483; rs11690583; rs1898586; rs2365622; rs13021356; rs10194612; rs12466205; rs2695745; rs2886422; rs998061; rs16865694; rs10930812; rs11683425; rs11896144; rs13413731; rs17401916; rs12615826; rs1918346; rs13399957; rs10195497; rs1405644; rs3770022; rs7578601; rs10171079; rs13406220; rs16823484; rs3214674; rs16865907; rs16865999; rs6433681; rs10803914; rs13411661; rs16865668; rs10166083; rs10203217; rs16865764; rs17687217; rs2950408; rs10164794; rs2695105; rs10187879; rs6735911; rs13385960; rs6714147; rs16865711; rs6714540; rs1405717; rs13403540; rs13395159; rs4893838; rs6712039; rs6735387; rs1438041; rs11894110; rs16866043; rs17401986; rs6709222; rs7562940; rs6743194; rs10173243; rs13012088; rs4893983; rs1561315; rs3770027; rs10202188; rs934568; rs10190154; rs10206282; rs10182386; rs16865670; rs2043547; rs2695096; rs6761540; rs1438058; rs13421135; rs10180071; rs10172247; rs17329811; rs11885795; rs13391629; rs16865533; rs6706739; rs9973525; rs2886423; rs16865951; rs10930811; rs1949966; rs764780; rs934805; rs7575717; rs16865647; rs13412181; rs13421415; rs7591504; rs10165089; rs9989817; rs11898798; rs13023495; rs6726253; rs1852498; rs6731843; rs7565183; rs3821011; rs16865869; rs16865868; rs10930822; rs1438059; rs10189110; rs12151805; rs16865940; rs16865591; rs1527297; rs7581861; rs11901771; rs1530036; rs10190066; rs7560737; rs2695750; rs714529; rs6433683; rs16865838; rs7592731; rs13396204; rs7563140; rs6704966; rs10930818; rs3770054; rs1344919; rs2695095; rs13397448; rs16865903; rs16865514; rs6731684; rs17401671; rs2365894; rs6726809; rs16865829; rs13423418; rs4143805; rs10178433; rs2695727; rs16865678; rs16865641; rs16865676; rs10167783; rs10168657; rs13425796; rs16865709; rs10192255; rs6711886; rs13396207; rs16865767; rs7588187; rs13395521; rs6713949; rs13409414; rs7592459; rs1438047; rs1527404; rs6709092; rs10176133; rs10930804; rs9989802; rs3770032; rs9677392; rs7565182; rs16865776; rs2365897; rs16865509; rs10930821; rs13400109; rs13400411; rs11899873; rs16865858; rs16865617; rs13414329; rs1358300; rs9288012; rs7585543; rs4377360; rs11902106; rs2020215; rs6717814; rs7573820; rs6433684; rs16865576; rs10166758; rs10211341; rs13394477; rs35397469; rs6756948; rs4893973; rs17687668; rs12469439; rs10186953; rs13387463; rs16865769; rs16865818; rs16865833; rs2060491; rs10177961; rs13028692; rs11674779; rs4893974; rs9677970; rs13386870; rs10169010; rs16865508; rs2365623; rs10930813; rs11890088; rs16865862; rs13002444; rs35987785; rs16865885; rs3952630; rs1344921; rs16865700; rs7581711; rs13392161; rs11682753; rs16866034; rs3821006; rs726985; rs16865689; rs10209050; rs3770046; rs7565179; rs3770029; rs16865701; rs6718100; rs9677090; rs934570; rs4474917; rs16865501; rs6723031; rs6730406; rs920092; rs6723063; rs920093; rs6722891; rs920094; rs1347440; rs920095; rs12468187; rs34839657; rs35253164; rs1946702; rs35210671; rs1982132; rs34365455; rs13005502; rs3056853; rs2695736; rs35071676; rs35669568; rs7421536; rs10167777; rs35607901; rs10201731; rs34374310; rs12994303; rs35897066; rs941366; rs35952531; rs34795277; rs35691085; rs7586771; rs10183014; rs28679800; rs34956941; rs34744300; rs34148524; rs13423344; rs34041168; rs6708473; rs35233809; rs34463789; rs10183536; rs34568807; rs35365213; rs34298599; rs3770031; rs35641196; rs13427473; rs41429950; rs35218489; rs35716038; rs35168006; rs35207489; rs35698274; rs34234621; rs34528505; rs3067363; rs2695100; rs5836630; rs10669353; rs41397549; rs35200915; rs12615720; rs13428260; rs1595442; rs35815103; rs11457930; rs35972715; rs35782989; rs35450676; rs33997655; rs35184228; rs11273279; rs34378430; rs35625068; rs13413922; rs35931940; rs12465589; rs34717744; rs34130310; rs12991811; rs13407054; rs956410; rs7567962; rs35810469; rs12998308; rs12992347; rs2886652; rs5836633; rs5836625; rs3813254; rs10174152; rs13409408; rs34459847; rs34543540; rs11421886; rs1438052; rs10654194; rs13011140; rs11457660; rs6433692; rs16865870; rs28380215; rs7600557; rs16865855; rs34233581; rs34509785; rs35068650; rs35319085; rs35244974; rs6741812; rs36180727; rs2366351; rs35894325; rs28700947; rs35793465; rs12990178; rs11352844; rs11304036; rs6147043; rs2695110; rs34434094; rs34839662; rs13409520; rs16865786; rs3056901; rs13013052; rs11895601; rs34245692; rs35699369; rs34622176; rs34326338; rs16866002; rs35267683; rs3056858; rs5836628; rs35020639; rs34909518; rs34605619; rs34338097; rs35391652; rs10195936; rs11290620; rs1852499; rs34327277; rs6758508; rs12989513; rs2695114; rs5836640; rs28496693; rs36051210; rs4302244; rs34025288; rs4110130; rs9677138; rs10167356; rs10622468; rs35391362; rs34677149; rs13408009; rs2695758; rs35268083; rs10558379; rs34921790; rs36186712; rs13399953; rs35319486; rs34242723; rs6710818; rs34632698; rs10167418; rs13383696; rs3905344; rs5836622; rs35615752; rs1123138; rs35635398; rs10654163; rs10527143; rs34093593; rs35892092; rs12989062; rs35775900; rs3835950; rs10187874; rs34928961; rs36003437; rs5836636; rs34403322; rs6756270; rs35443310; rs2695749; rs34356580; rs10686756; rs13018347; rs3835952; rs28498363; rs34698321; rs33980746; rs12999814; rs7575777; rs35723966; rs11400619; rs35537949; rs12151372; rs35063921; rs3073405; rs35277317; rs11460197; rs34661271; rs33952943; rs11297475; rs9679102; rs10209248; rs34358653; rs6739045; rs10193573; rs34678364; rs34644164; rs16823485; rs35134722; rs11365222; rs2573081; rs35105885; rs10176536; rs6433689; rs2695751; rs1020011; rs34334554; rs13409454; rs13426623; rs10546304; rs7569826; rs13024864; rs4417752; rs11357476; rs11423127; rs6753377; rs1438043; rs10697352; rs13426123; rs11374940; rs36043707; rs35875834; rs34479958; rs12328658; rs34144749; rs34283040; rs35610210; rs13002398; rs2695093; rs35805580; rs3841879; rs5836635; rs35486028; rs35969908; rs36121526; rs4893990; rs7584732; rs36197320; rs34088312; rs2695318; rs36130267; rs10190750; rs1866213; rs11304532; rs12466953; rs3056896; rs941273; rs13409258; rs34430258; rs36033403; rs11332498; rs34293348; rs34718493; rs34648335; rs35600620; rs35749062; rs13420280; rs34108864; rs35262842; rs13432633; rs35217344; rs7607438; rs13021169; rs13001148; rs10176527; rs34087687; rs28590730; rs35758079; rs13416761; rs35427161; rs13001447; rs10557532; rs4019842; rs12986929; rs3835949; rs16865485; rs36058776; rs11399942; rs36210065; rs6729893; rs5836632; rs35228328; rs6731331; rs13013706; rs941365; rs34385021; rs35391554; rs35885074; rs35323285; rs10168683; rs34952652; rs34444737; rs34330215; rs36118068; rs4464320; rs35219250; rs13382373; rs12992086; rs34973644; rs13018404; rs16865713; rs4893982; rs10211625; rs34035940; rs2950572; rs6758139; rs35812247; rs7421535; rs35011517; rs3067362; rs12995165; rs13430954; rs5836641; rs12999027; rs35046636; rs12612301; rs34596457; rs35254631; rs35906687; rs4297923; rs1975322; rs34035499; rs1527289; rs35862134; rs3770042; rs2091441; rs34406776; rs9677777; rs13007385; rs10556235; rs34486056; rs13029844; rs35102487; rs13023837; rs10692818; rs34464620; rs34330915; rs35517342; rs35848472; rs34582585; rs16865918; rs35288915; rs35902413; rs13389387; rs6433707; rs34369002; rs34417507; rs34790520; rs34510795; rs34612479; rs34602607; rs2365624; rs10209852; rs2695761; rs11457371; rs3056940; rs35549571; rs28791491; rs11892897; rs36013928; rs11887774; rs10176535; rs35290022; rs6725044; rs33984696; rs35420167; rs10172384; rs34505237; rs12997716; rs12994392; rs34366957; rs34210867; rs34772724; rs1852496; rs12618253; rs36180284; rs35305315; rs12992938; rs36003055; rs34392533; rs34682002; rs10685021; rs34595897; rs5836620; rs3830637; rs35655847; rs1438044; rs2573084; rs35231531; rs34945224; rs35156922; rs12472798; rs34934707; rs10669885; rs13009183; rs35939912; rs5836626; rs35688482; rs7571646; rs11310982; rs34365395; rs33967413; rs7421195; rs34327803; rs10572990; rs35642038; rs10175142; rs6433696; rs4893846; rs13007409; rs34717034; rs35462778; rs5836619; rs10432484; rs11333080; rs33971104; rs12993389; rs4487117; rs5836631; rs35217913; rs3037874; rs35797524; rs13031478; rs34142188; rs34917842; rs11685582; rs3037901; rs35338943; rs5836623; rs34767203; rs6712779; rs34682886; rs34206020; rs12472460; rs35337472; rs3073403; rs883171; rs13023528; rs10190560; rs3066395; rs35421971; rs13019139; rs35798690; rs13408844; rs11901207; rs34902120; rs34884047; rs34567061; rs1438042; rs10603345; rs13010993; rs34794477; rs35316377; rs35726367; rs13013319; rs35837681; rs35253854; rs5836638; rs5836629; rs13391481; rs6731280; rs34147365; rs3770021; rs34261053; rs28787871; rs35996255; rs13029944; rs13016598; rs2695722; rs35267698; rs28867487; rs13033904; rs36022334; rs11378638; rs34355087; rs34532538; rs12994400; rs34743754; rs12992244; rs13401710; rs10608828; rs34449576; rs13431317; rs13406131; rs35757742; rs35810822; rs36042877; rs1609094; rs2695739; rs2365891; rs34096798; rs959791; rs1467360; rs34758781; rs3770041; rs12998843; rs34556327; rs36035504; rs35120376; rs34413904; rs11898579; rs6708580; rs34448095; rs10178916; rs36005794; rs10187897; rs34650718; rs35691613; rs35343829; rs35952657; rs1438057; rs10178858; rs2717524; rs2118483; rs7602131; rs2695090; rs3056854; rs34059969; rs36021106; rs10185318; rs34216494; rs10211637; rs11680530; rs35104703; rs10690181; rs13017462; rs5025339; rs34171827; rs3770037; rs11333128; rs34330646; rs2695759; rs10185973; rs34484134; rs5015687; rs3031405; rs35765328; rs10684663; rs13031632; rs34503988; rs34692952; rs36088611; rs36161140; rs7605249; rs2695733; rs3770030; rs11333208; rs11457658; rs2196339; rs10700821; rs11409979; rs33971087; rs35212627; rs12476700; rs4464321; rs34302432; rs10194586; rs35611922; rs28408453; rs13007673; rs13415041; rs33957872; rs5836637; rs35064446; rs34364822; rs7571908; rs35531468; rs10613859; rs34995971; rs34148492; rs35924394; rs35678669; rs13405755; rs4487116; rs10614762; rs35194777; rs13028628; rs12473852; rs35134190; rs12990878; rs35887587; rs3948256; rs34381368; rs10182833; rs35525333; rs2573086; rs3067378; rs34721738; rs10534597; rs2365890; rs13405457; rs10183345; rs13394193; rs941275; rs4536679; rs35362919; rs10176643; rs13026166; rs13006712; rs13385419; rs12233175; rs13001444; rs2717525; rs33997176; rs11363547; rs28529577; rs12992252; rs10427227; rs35631376; rs11367453; rs35097265; rs12612164; rs34842463; rs6414096; rs10187884; rs35795321; rs35302466; rs13416636; rs13024861; rs35990574; rs2695754; rs7605985; rs10185145; rs10182353; rs3056942; rs13018132; rs34938001; rs35041048; rs10539109; rs13024254; rs11329681; rs34952215; rs2695106; rs13418653; rs13421345; rs5836627; rs34513757; rs35586165; rs3056937; rs13020684; rs34383497; rs6738358; rs7571919; rs5015686; rs10556225; rs12988281; rs13388218; rs34385779; rs34054341; rs35335000; rs10930808; rs11291265; rs28707296; rs2366350; rs34624647; rs12992249; rs2886425; rs34878348; rs35248478; rs13001522; rs34660521; rs34081471; rs4341976; rs35975029; rs35773107; rs13418469; rs34682348; rs35764219; rs10182017; rs10186697; rs6731030; rs35927962; rs34281475; rs34018298; rs35782761; rs12987271; rs7558482; rs1918345; rs34823486; rs4110136; rs11284596; rs34568974; rs34915755; rs13405581; rs34164632; rs35225617; rs3770017; rs3037903; rs13427846; rs34702209; rs9646739; rs4538242; rs35978357; rs35481440; rs1344918; rs34948302; rs10564225; rs35303018; rs10534752; rs13022267; rs3770020; rs35929026; rs41394144; rs13002209; rs13027484; rs2118481; rs10563932; rs35404128; rs34110195; rs6758644; rs34323062; rs2196340; rs35748044; rs41440047; rs34246439; rs13427452; rs34792403; rs12994590; rs35830357; rs13396582; rs10579905; rs13012298; rs13385424; rs35517887; rs11450947; rs35522885; rs1358301; rs6713660; rs35696051; rs10629866; rs35973852; rs35591668; rs28771225; rs12472515; rs34764794; rs34507449; rs13383409; rs34473216; rs34249286; rs10803913; rs4338993; rs35420534; rs1880915; rs2695113; rs35520979; rs34473720; rs6723691; rs35578521; rs35733927; rs13023390; rs13023494; rs4893836; rs35983142; rs5836639; rs2695107; rs35749582; rs34149684; rs13019623; rs1438050; rs36046079; rs28621588; rs13385949; rs2083156; rs10541503; rs6716288; rs34335666; rs3066392; rs35403482; rs34431240; rs35439189; rs35316735; rs3056898; rs5836624; rs28889598; rs7421650; rs10187888; rs11343355; rs28536016; rs6147041; rs7420029; rs2037758; rs10930807; rs7565114; rs34185358; rs10192928; rs35873373; rs3031403; rs13020834; rs5836618; rs10211632; rs16865909; rs35728831; rs13025164; rs36032173; rs6147042; rs36149489; rs35130337; rs34164917; rs34684690; rs35836349; rs34215270; rs12992250; rs34628381; rs7573440; rs13017254; rs41357848; rs10178473; rs2365892; rs10693827; rs9646738; rs35538692; rs35385829; rs33947390; rs36106717; rs34752624; rs7589980; rs34839058; rs35709030; rs34699522; rs6747137; rs13393975; rs34571198; rs36062129; rs2196694; rs34747248; rs6711034; rs12987107; rs35510151; rs34363929; rs10558072; rs5836634; rs34047994; rs1609095; rs13013724; rs34293884; rs13419130; rs2695755; rs934810; rs34044811; rs2196341; rs36094310; rs3770049; rs3056903; rs12993458; rs7594362; rs13002711; rs13002713; rs13027895; rs11694013; rs34941794; rs10174337; rs10209616; rs1047884; rs11676719; rs12620285; rs12990917; rs13023049; rs13032997; rs13033229; rs13397357; rs13419755; rs13421475; rs1369517; rs1405643; rs1435572; rs1527286; rs1527287; rs1534304; rs16865452; rs16865453; rs16865475; rs16865476; rs16865993; rs16866025; rs16866053; rs16866058; rs17330381; rs1836672; rs1982130; rs2117739; rs2293471; rs2293472; rs2293473; rs3829751; rs3829752; rs4436997; rs4893970; rs6710329; rs6720272; rs6726222; rs6740828; rs6752913; rs6754705; rs6756918; rs7574975

# Macromolecular_Interacting_Partner_68_General_References:
Not Available

# Macromolecular_Interacting_Partner_68_References:
Not Available

End of HMDB00058

Beginning of HMDB00060
# Accession_No:
HMDB00060

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-17 14:03:29

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Acetoacetic acid

# Description:
It is a weak organic acid and can be produced in the human liver under certain conditions of poor metabolism leading to excessive fatty acid breakdown (diabetes mellitus leading to diabetic ketoacidosis), it is then partially converted to acetone by decarboxylation and excreted either in urine or through respiration.  Persistent mild hyperketonemia is a common finding in newborns. These compounds serve as an indispensable source of energy for extrahepatic tissues, especially the brain and lung of developing rats.  Another important function of ketone bodies is to provide acetoacetyl-CoA and acetyl-CoA for synthesis of cholesterol, fatty acids, and complex lipids.  During the early postnatal period, acetoacetate (AcAc) and beta-hydroxybutyrate are preferred over glucose as substrates for synthesis of phospholipids and sphingolipids in accord with requirements for brain growth and myelination.  Thus, during the first 2 wk of postnatal development, when the accumulation of cholesterol and phospholipids accelerates, the proportion of ketone bodies incorporated into these lipids increases.  On the other hand, an increased proportion of ketone bodies are utilized for cerebroside synthesis during the period of active myelination.  In the lung, AcAc serves better than glucose as a precursor for the synthesis of lung phospholipids.  The synthesized lipids, particularly dipalmityl phosphatidylcholine, are incorporated into surfactant, and thus have a potential role in supplying adequate surfactant lipids to maintain lung function during the early days of life. (PMID 3884391) The acid is also present in the metabolism of those undergoing starvation or prolonged physical exertion as part of gluconeogenesis. When ketone bodies are measured by way of urine concentration, acetoacetic acid, along with beta-hydroxybutyric acid or acetone, is what is detected.

# Synonyms:
3-Ketobutyrate; 3-Oxo-butanoate; 3-Oxo-butanoic acid; 3-Oxobutyrate; 3-Oxobutyric acid; Acetoacetate;  diacetate; diacetic acid

# Chemical_IUPAC_Name:
3-oxobutanoic acid

# Chemical_Formula:
C4H6O3

# Chemical_Structure:
tbl_chemical:::HMDB00060_ZOOM.png:::119283164088650913

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00060_THUMB.png:::119283163910695715

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
ketone; carboxylic acid

# Taxonomy_Biofunction:
Component of Butanoate metabolism; Component of Tyrosine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
102.03169

# Molecular_Weight_Avg:
102.08864

# Smiles_String_isomeric:
CC(=O)CC(O)=O

# Smiles_String_canonical:
CC(=O)CC(O)=O

# KEGG_Compound_ID:
C00164

# BioCyc_ID:
3-KETOBUTYRATE

# PubChem_CID:
96

# PubChem_SID:
3464; 2004; 837871; 7885617; 548568; 545908; 4492762; 7850244; 830744; 154233; 7985318; 7888655; 841346; 8150453

# OMIM_ID:
245050; 246450

# Metagene_ID:
KETOSIS, UNSPECIFIC [DD]: 279; BETA-KETOTHIOLASE DEFICIENCY: 5

# BiGG_ID:
1485291

# Wikipedia_ID:
Acetoacetic acid

# METLIN_ID:
276

# Ref_ID:
1293081; 8579834; 15627241; 15982426; 1644440; 6696735; 10753479; 2014530; 404361; 8412012; 9710942; 7762816; 10909075; 11499803; 16720683; 10030312; 15880082; 6321058; 15332353; 12691858

# ChEBI_ID:
15344

# CAS_Registry_Number:
541-50-4

# InChI:
InChI=1/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)

# Synthesis_Reference:
Chemical & Pharmaceutical Bulletin  (1981),  29(10),  2762-8.

# Melting_Point:
36.5 oC

# Melting_Point_predicted:
23.4 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1000 mg/mL at 20 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
240.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-0.47 [Predicted by ALOGPS]; 0 [Predicted by PubChem via XLOGP]; -0.98 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00060_msds.html:::1132562195182443894

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Acetoacetic_acid.mol:::1132723804250757776

# SDF_File_[Text]:
tbl_chemical:::HMDB00060.sdf:::119283163570944603

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00060.pdb:::119283163737962531

# PDB_ID:
1QCO

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1QCO.txt:::1132720900562666648

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041201_P04_18_BA_1DP_noesy.png:::116890067102193817260

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041201_P04_18_BA_1DP_presat.zip:::115168942677189803

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041201_P04_18_BA_1DP_Assigned.png:::115168942685780479

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::041201_P04_18_BA_1DC_74.jpg:::114168459264823026

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041201_P04_18_BA_1DC_74.zip:::114168459260521409

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041201_P04_18_BA_1DC_74_Assigned.jpg:::11432279045576680

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041201_P04_18_BA_2DHSQC_244.jpg:::114564728974110660

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041201_P04_18_BA_2DHSQC_244.zip:::114564728981542282

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041201_P04_18_BA_2DHSQC_244_Assigned.jpg:::11456472904706757

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Acetoacetic acid.gif:::1132732103968335650

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00060_peaks.txt:::115630951835586901

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Acetoacetic acid_C.gif:::1132737670876834590

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00060_peaks.txt:::1156310708815523079

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00060.png:::1166589860805683045; Medium Energy:tbl_ms:::HMDB00060.png:::1166589558034696474; High Energy:tbl_ms:::HMDB00060.png:::1166589658030422444

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria; peroxisome

# Tissue_Location:
Fibroblasts; Liver; Lymphocyte; Neurons; Spleen

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Cellular Cytoplasm; Urine

# Concentration_[Normal]:
Urine	33.0(0.00-67.0)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	6321058
Blood	21.0 (0.0-86.0)	umol/L	Adult:>18_yrs_old	Both	Normal	8412012
Blood	142800.0 +/- 3200.0	uM	Adult:>18_yrs_old	Both	Normal	3596078 
Cerebrospinal_Fluid(CSF)	26.2 +/- 12.3	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	6.0 +/- 6.0	umol/L	Adult:>18_yrs_old	N/A	Normal	8412012
Cerebrospinal_Fluid(CSF)	42.0 +/- 47.0	uM	Adult:>18_yrs_old	Both	Normal	HMP Experimental
Cellular_Cytoplasm	1700 (1500-1900)	umol/L	Adult:>18_yrs_old	Both	Normal	8579834


# Concentration_[Abnormal]:
Urine	237.0	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Diabetes	6321058
Blood	3030.0 (3010.0-3050.0)	umol/L	Adult:>18_yrs_old	Both	Diabetic Ketoacidosis	15982426
Blood	143300.0 +/- 2300.0	uM	Adult:>18_yrs_old	Both	Type 1 insulin dependent diabetic patients	3596078 
Cerebrospinal_Fluid(CSF)	248 +/- 179	uM	Children:1-13_yrs_old	N/A	Glucose transporter type 1 deficiency syndrome	14769490
Cerebrospinal_Fluid(CSF)	322.0 (240.0-404.0)	umol/L	Adult:>18_yrs_old	Both	Bacterial meningitis	15627241
Cellular_Cytoplasm	1000 (800-1200)	umol/L	Adult:>18_yrs_old	Both	Anoxia	8579834


# Associated_Disorders:
Anoxia; Bacterial meningitis; Diabetes; Diabetic Ketoacidosis; Glucose transporter type 1 deficiency syndrome; Ketonemia; Ketosis; Ketosis, Unspecific [DD]; Type 1 insulin dependent diabetic patients

# Pathway_Names:
Synthesis and degradation of ketone bodies;Valine, leucine and isoleucine degradation;Butanoate metabolism;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
Ketone_bodies.jpg;valine,leucine,and_isoleucine_degradation.jpg;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
;map00280;map00650;map00280;map00280

# Pathway_Graphs:
Ketone_bodies_Graph.jpg;valine,leucine,and_isoleucine_degradation_Graph.jpg;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
Ketone_bodies.xml;valine,leucine,and_isoleucine_degradation.xml;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5238

# Metabolic_Enzyme_1_Name:
Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
HMG-CoA lyase; HL; 3-hydroxy-3-methylglutarate-CoA lyase

# Metabolic_Enzyme_1_Gene_Name:
HMGCL

# Metabolic_Enzyme_1_Protein_Sequence:
>HydroxymethylglutarylCoA lyase, mitochondrial precursor
MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
DMLSEAGLSV
IETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAA
GAKEVVIFGAASELFTKKNIN
CSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEG
KISPAKVAEVTKKFYSMGCYEISLGDTIGVGT
PGIMKDMLSAVMQEVPLAALAVHCHDT
YGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATED
LVYMLEGLGIHTGVNL
QKLLEAGNFICQALNRKTSSKVAQATCKL

# Metabolic_Enzyme_1_Number_of_Residues:
325

# Metabolic_Enzyme_1_Molecular_Weight:
34361

# Metabolic_Enzyme_1_Theoretical_pI:
8.71

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  oxo-acid-lyase activity
Function:  hydroxymethylglutaryl-CoA lyase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
(S)-3-hydroxy-3-methylglutaryl-CoA = acetyl- CoA + acetoacetate

# Metabolic_Enzyme_1_Pathway:
map00072  Synthesis and degradation of ketone bodies;
 map00280  Valine, leucine and isoleucine degradation;
 map00650  Butanoate metabolism

# Metabolic_Enzyme_1_Reaction:
(S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00682:HMGL-like

# Metabolic_Enzyme_1_Signals:
1-23

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 4.1.3.4

# Metabolic_Enzyme_1_GenBank_ID_Protein:
184503

# Metabolic_Enzyme_1_SwissProt_ID:
HMGCL_HUMAN (P35914)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
HMGCL

# Metabolic_Enzyme_1_Geneatlas_id:
HMGCL

# Metabolic_Enzyme_1_hgnc_id:
HGNC:5005

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_1_Gene_Sequence:
>978 bp

ATGGCAGCAATGAGGAAGGCGCTTCCGCGGCGACTGGTGGGCTTGGCGTCCCTCCGGGC
TGTCAGCACCT
CATCTATGGGCACTTTACCAAAGCGGGTGAAAATTGTGGAAGTTGGTC
CCCGAGATGGACTACAAAATGA
AAAGAATATCGTATCTACTCCAGTGAAAATCAAGCTG
ATAGACATGCTTTCTGAAGCAGGACTCTCTGTT
ATAGAAACCACCAGCTTTGTGTCTCC
TAAGTGGGTTCCCCAGATGGGTGACCACACTGAAGTCTTGAAGG
GCATTCAGAAGTTTC
CTGGCATCAACTACCCAGTCCTGACCCCAAATTTGAAAGGCTTCGAGGCAGCGGT
TGCT
GCTGGAGCCAAGGAAGTAGTCATCTTTGGAGCTGCCTCAGAGCTCTTCACCAAGAAGAAC
ATCAAT
TGTTCCATAGAGGAGAGTTTTCAGAGGTTTGACGCAATCCTGAAGGCAGCGCA
GTCAGCCAATATTTCTG
TGCGGGGGTACGTCTCCTGTGCTCTTGGCTGCCCTTATGAAG
GGAAGATCTCCCCAGCTAAAGTAGCTGA
GGTCACCAAGAAGTTCTACTCAATGGGCTGC
TACGAGATCTCCCTGGGGGACACCATTGGTGTGGGCACC
CCAGGGATCATGAAAGACAT
GCTATCTGCTGTCATGCAGGAAGTGCCTCTGGCTGCCCTGGCTGTCCACT
GCCATGACA
CCTATGGTCAAGCCCTGACCAACACCTTGATGGCCCTGCAGATGGGAGTGAGTGTCGTGG
A
CTCTTCTGTGGCAGGACTTGGAGGCTGTCCCTACGCACAGGGGGCATCAGGAAACTTG
GCCACAGAAGAC
CTGGTCTACATGCTAGAGGGCTTGGGCATTCACACGGGTGTGAATCT
CCAGAAGCTTCTGGAAGCTGGAA
ACTTTATCTGTCAAGCCCTGAACAGAAAAACTAGCT
CCAAAGTGGCTCAGGCTACCTGTAAACTCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
L07033

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_1_Locus:
1p36.1-p35

# Metabolic_Enzyme_1_SNPs:
rs719400; rs2179395; rs2502979; rs2256179; rs719399; rs974698; rs1018396; rs2982390; rs2076344; rs2473375; rs16828744; rs2502987; rs2473377; rs2281181; rs2502980; rs6679378; rs2502986; rs11591205; rs6424115; rs7550538; rs6697805; rs11551767; rs35056782; rs6682888; rs12025531; rs34267634; rs34174636; rs12743865; rs12755251; rs35127060; rs12734500; rs7540056; rs11583935; rs34801023; rs6698535; rs12116596; rs2473374; rs11371330; rs35469537; rs12138604; rs2179394; rs34719552; rs12136069; rs12735628; rs12138610; rs3835225; rs35297134; rs12140263; rs2473376; rs34161775; rs11588187; rs34883557; rs10554242; rs12735627; rs34651393; rs12136042; rs12044452; rs6698536; rs35216362; rs12083298; rs2502978; rs12138606; rs12755402; rs6696932; rs12136045; rs12116617; rs6424114; rs12754130; rs33913125; rs36047946; rs10641596; rs6143166; rs34538286; rs5773058; rs35813936; rs10641595; rs36005512; rs1042436; rs1049988; rs10917426; rs11714; rs12031592; rs12131539; rs1803612; rs1803613; rs2076343; rs2232977; rs2232978; rs2232979; rs2232980; rs2232981; rs2232983; rs2473382; rs28940882; rs28940883; rs28940885; rs3177810; rs3177811; rs3177814; rs3179862; rs3180382; rs3180383; rs3180545; rs3180546; rs3180547; rs3180549; rs3203593; rs3209973; rs6692104; rs7519554; rs7521961; rs7524513; rs7529275; rs760941

# Metabolic_Enzyme_1_General_References:
8440722; 8617516; 8798725; 9463337; 11129331

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5985

# Metabolic_Enzyme_2_Name:
Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial precursor

# Metabolic_Enzyme_2_Synonyms:
Somatic-type succinyl CoA:3-oxoacid CoA- transferase; Scot-S

# Metabolic_Enzyme_2_Gene_Name:
OXCT1

# Metabolic_Enzyme_2_Protein_Sequence:
>SuccinylCoA:3ketoacidcoenzyme A transferase 1, mitochondrial precursor
MAALKLLSSGLRLCASARGSGATWYKGCVCSFSTSAHRHTKFYTDPVEAVKDIPDGATVL
VGGFGLCGIPENLIDALLKTGVKGLTAVSNNAGVDNFGLGLLLRSKQIKRMVSSYVGENA
EFERQYLSGELEVELTPQGTLAERIRAGGAGVPAFYTPTGYGTLVQEGGSPIKYNKDGSV
AIASKPREVREFNGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAET
TVVEVEEIVDIGAFAPEDIHIPQIYVHRLIKGEKYEKRIERLSIRKEGDGEAKSAKPGDD
VRERIIKRAALEFEDGMYANLGIGIPLLASNFISPNITVHLQSENGVLGLGPYPRQHEAD
ADLINAGKETVTILPGASFFSSDESFAMIRGGHVDLTMLGAMQVSKYGDLANWMIPGKMV
KGMGGAMDLVSSAKTKVVVTMEHSAKGNAHKIMEKCTLPLTGKQCVNRIITEKAVFDVDK
KKGLTLIELWEGLTVDDVQKSTGCDFAVSPKLMPMQQIAN

# Metabolic_Enzyme_2_Number_of_Residues:
520

# Metabolic_Enzyme_2_Molecular_Weight:
56158

# Metabolic_Enzyme_2_Theoretical_pI:
7.52

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  CoA-transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate

# Metabolic_Enzyme_2_Pathway:
map00072  Synthesis and degradation of ketone bodies;
 map00280  Valine, leucine and isoleucine degradation;
 map00650  Butanoate metabolism

# Metabolic_Enzyme_2_Reaction:
succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01144:CoA_trans

# Metabolic_Enzyme_2_Signals:
1-22

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.8.3.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1519052

# Metabolic_Enzyme_2_SwissProt_ID:
SCOT_HUMAN (P55809)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
OXCT1

# Metabolic_Enzyme_2_Geneatlas_id:
OXCT1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:8527

# Metabolic_Enzyme_2_PDB_ID:
1OOY

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_2_Gene_Sequence:
>1563 bp
ATGGCGGCTCTCAAACTCCTCTCCTCCGGGCTTCGGCTCTGCGCCTCTGCCCGCGGATCT
GGGGCAACCTGGTACAAGGGATGTGTTTGTTCCTTTTCCACCAGTGCTCATCGCCATACC
AAGTTTTATACAGATCCAGTAGAAGCTGTAAAAGACATCCCTGATGGTGCCACGGTTTTG
GTTGGTGGTTTTGGGCTATGTGGAATTCCAGAGAATCTTATAGATGCTTTACTGAAAACT
GGAGTAAAAGGACTAACTGCAGTCAGCAACAATGCAGGGGTTGACAATTTTGGTTTGGGG
CTTTTGCTTCGGTCGAAGCAGATAAAACGCATGGTCTCTTCATATGTGGGAGAAAATGCA
GAATTTGAACGACAGTACTTATCTGGTGAATTAGAAGTGGAGCTGACACCACAGGGCACA
CTTGCAGAGAGGATCCGTGCAGGCGGGGCTGGAGTTCCTGCATTTTACACCCCAACAGGG
TATGGGACCCTGGTACAAGAAGGAGGATCGCCCATCAAATACAACAAAGATGGCAGTGTT
GCCATTGCCAGTAAGCCAAGAGAGGTGAGGGAGTTCAATGGTCAGCACTTTATTTTGGAG
GAAGCAATTACAGGGGATTTTGCTTTGGTGAAAGCCTGGAAGGCGGACCGAGCAGGAAAC
GTGATTTTCAGGAAAAGTGCAAGGAATTTCAACTTGCCAATGTGCAAAGCTGCAGAAACC
ACAGTGGTAGAGGTTGAAGAAATTGTGGATATTGGAGCATTTGCTCCAGAAGACATCCAT
ATTCCTCAGATTTATGTACATCGCCTTATAAAGGGAGAAAAATATGAGAAAAGAATTGAG
CGTTTATCAATCCGGAAAGAGGGAGATGGGGAAGCCAAATCTGCTAAACCTGGAGATGAC
GTAAGGGAACGAATCATCAAGAGGGCCGCTCTTGAGTTTGAGGATGGCATGTATGCTAAT
TTGGGCATAGGAATCCCTCTCCTGGCCAGCAATTTTATCAGCCCAAATATAACTGTTCAT
CTTCAAAGTGAAAATGGAGTTCTGGGTTTGGGTCCATATCCACGACAACATGAAGCTGAT
GCAGATCTCATCAATGCAGGCAAGGAAACAGTTACTATTCTTCCAGGAGCCTCTTTTTTC
TCCAGCGATGAATCATTTGCAATGATTAGAGGTGGACACGTCGATCTGACAATGCTAGGA
GCGATGCAGGTTTCCAAATATGGTGACCTGGCTAACTGGATGATACCTGGGAAGATGGTG
AAAGGAATGGGAGGTGCTATGGATTTAGTGTCCAGTGCGAAAACCAAAGTGGTGGTCACC
ATGGAGCATTCTGCAAAGGGAAATGCACATAAAATCATGGAGAAATGTACATTACCATTG
ACTGGAAAGCAATGTGTCAACCGCATTATTACTGAAAAGGCTGTGTTTGATGTGGACAAG
AAGAAAGGGTTGACTCTGATTGAGCTCTGGGAAGGCCTGACAGTGGATGACGTACAAAAG
AGTACTGGGTGTGATTTTGCAGTTTCACCAAAACTCATGCCAATGCAGCAGATCGCAAAT
TGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
U62961

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_2_Locus:
5p13.1

# Metabolic_Enzyme_2_SNPs:
rs10078011; rs11738517; rs1027348; rs13360001; rs11739257; rs4245982; rs4957424; rs951883; rs11744516; rs2329815; rs4957422; rs6861720; rs6881873; rs1508815; rs6866549; rs1494392; rs7712911; rs964267; rs10075064; rs6451581; rs1533014; rs11747921; rs11740524; rs16871972; rs6869822; rs7723992; rs11745373; rs10941557; rs16871955; rs11747881; rs3922473; rs7729014; rs7709500; rs17213962; rs11750760; rs10512794; rs316760; rs4957429; rs6888816; rs11746511; rs11740946; rs11744623; rs6889217; rs11750790; rs10038001; rs11744279; rs6879341; rs11748259; rs10512793; rs9687619; rs11749008; rs1876653; rs6862015; rs10069904; rs6869616; rs4050986; rs16900142; rs13153468; rs13163137; rs7733096; rs6883144; rs16871981; rs12186512; rs11738956; rs10214013; rs34663371; rs4957419; rs6895810; rs966000; rs13185973; rs9292825; rs13169977; rs12651888; rs7733095; rs13354429; rs9292827; rs7726722; rs13165517; rs16871938; rs4957425; rs36113900; rs1355089; rs10038717; rs13176368; rs13168035; rs11739106; rs1112842; rs4957430; rs9763018; rs9292826; rs10941559; rs13177937; rs17648418; rs7712274; rs10462025; rs13164201; rs13182336; rs16871940; rs1876654; rs4957170; rs1136453; rs17847290; rs35498423; rs17847291; rs35292693; rs17847289; rs316759; rs10227; rs5867570; rs34534439; rs35111294; rs35986530; rs10614716; rs35343042; rs13357640; rs35657944; rs3050894; rs5867567; rs34743357; rs12187157; rs35777912; rs4957423; rs34182550; rs34796709; rs13358155; rs34647184; rs35760660; rs35520000; rs13163629; rs35461928; rs4391215; rs11269754; rs34095592; rs35232939; rs34217937; rs35252930; rs13165731; rs34543169; rs4957421; rs6861780; rs34569700; rs36056121; rs33971477; rs35407396; rs34690500; rs34369972; rs10717166; rs11355215; rs33941090; rs13158887; rs34339137; rs34684298; rs10668563; rs13159004; rs33916073; rs34625465; rs10653559; rs35341070; rs13156376; rs34533338; rs10064989; rs17739462; rs11363102; rs34873414; rs4358566; rs35030469; rs35548566; rs35908088; rs11285287; rs34950905; rs34244054; rs34179827; rs35077044; rs7726246; rs34523116; rs6869781; rs35199978; rs35328989; rs35127804; rs35861205; rs11291155; rs36056440; rs35662552; rs36117553; rs5867568; rs10036888; rs34787911; rs12187165; rs34104889; rs34329864; rs10039091; rs36121472; rs34329782; rs4610503; rs36005620; rs978756; rs35270749; rs35103408; rs35685731; rs35718798; rs7728678; rs35551668; rs11357997; rs35683310; rs11739266; rs35439946; rs4957418; rs34595449; rs4957428; rs34861623; rs34170008; rs35724241; rs35179878; rs28588578; rs13153837; rs34500930; rs34798229; rs34904161; rs17847293; rs2088050; rs36095905; rs34734165; rs34071445; rs13155013; rs11425534; rs13189192; rs7707408; rs34247204; rs1472921; rs33979858; rs34068426; rs4629635; rs34171671; rs3926618; rs36062757; rs17847285; rs35613904; rs9292828; rs10079815; rs33967331; rs11394511; rs7708534; rs13162040; rs17847288; rs10072903; rs28838579; rs6877299; rs28429157; rs13171121; rs10941558; rs34979401; rs35277781; rs35725846; rs5867569; rs17214025; rs2329744; rs13179852; rs35547017; rs3050897; rs4587120; rs13159122; rs13159471; rs33914245; rs34386184; rs34111981; rs4957420; rs35760529; rs34841703; rs17847294; rs966001; rs13182886; rs10045224; rs582852; rs35122737; rs34981875; rs34214254; rs10079575; rs1035486; rs11746530; rs11958154; rs12659601; rs13176076; rs1567323; rs17291699; rs316726; rs35764180; rs4131818; rs4957431; rs4957432; rs6882152; rs7716512; rs7724934; rs7728482; rs924436

# Metabolic_Enzyme_2_General_References:
8751852; 10964512; 9671268

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5986

# Metabolic_Enzyme_3_Name:
Fumarylacetoacetase

# Metabolic_Enzyme_3_Synonyms:
Fumarylacetoacetate hydrolase; Beta-diketonase; FAA

# Metabolic_Enzyme_3_Gene_Name:
FAH

# Metabolic_Enzyme_3_Protein_Sequence:
>Fumarylacetoacetase
MSFIPVAEDSDFPIHNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKHLFTGPVLSKHQD
VFNQPTLNSFMGLGQAAWKEARVFLQNLLSVSQARLRDDTELRKCAFISQASATMHLPAT
IGDYTDFYSSRQHATNVGIMFRDKENALMPNWLHLPVGYHGRASSVVVSGTPIRRPMGQM
KPDDSKPPVYGACKLLDMELEMAFFVGPGNRLGEPIPISKAHEHIFGMVLMNDWSARDIQ
KWEYVPLGPFLGKSFGTTVSPWVVPMDALMPFAVPNPKQDPRPLPYLCHDEPYTFDINLS
VNLKGEGMSQAATICKSNFKYMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGPEPENFG
SMLELSWKGTKPIDLGNGQTRKFLLDGDEVIITGYCQGDGYRIGFGQCAGKVLPALLPS

# Metabolic_Enzyme_3_Number_of_Residues:
419

# Metabolic_Enzyme_3_Molecular_Weight:
46375

# Metabolic_Enzyme_3_Theoretical_pI:
6.94

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid carbon-carbon bonds
Function:  hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances
Function:  fumarylacetoacetase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_3_Specific_Function:
4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate

# Metabolic_Enzyme_3_Pathway:
map00350  Tyrosine metabolism;
 map00643  Styrene degradation

# Metabolic_Enzyme_3_Reaction:
4-fumarylacetoacetate + H2O = acetoacetate + fumarate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF09298:DUF1969;
PF01557:FAA_hydrolase

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.7.1.2

# Metabolic_Enzyme_3_GenBank_ID_Protein:
182393

# Metabolic_Enzyme_3_SwissProt_ID:
FAAA_HUMAN (P16930)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
FAH

# Metabolic_Enzyme_3_Geneatlas_id:
FAH

# Metabolic_Enzyme_3_hgnc_id:
HGNC:3579

# Metabolic_Enzyme_3_PDB_ID:
1QQJ

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_3_Gene_Sequence:
>1260 bp
ATGTCCTTCATCCCGGTGGCCGAGGATTCCGACTTCCCCATCCACAACCTGCCCTACGGC
GTCTTCTCGACCAGAGGCGACCCAAGACCGAGGATAGGTGTGGCCATTGGCGACCAGATC
CTGGACCTCAGCATCATCAAGCACCTCTTTACTGGTCCTGTCCTCTCCAAACACCAGGAT
GTCTTCAATCAGCCTACACTCAACAGCTTCATGGGCCTGGGTCAGGCTGCCTGGAAGGAG
GCGAGAGTGTTCTTGCAGAACTTGCTGTCTGTGAGCCAAGCCAGGCTCAGAGATGACACC
GAACTTCGGAAGTGTGCATTCATCTCCCAGGCTTCTGCCACGATGCACCTTCCAGCCACC
ATAGGAGACTACACAGACTTCTATTCCTCTCGGCAGCATGCTACCAACGTCGGAATCATG
TTCAGGGACAAGGAGAATGCGTTGATGCCAAATTGGCTGCACTTACCAGTGGGCTACCAT
GGCCGTGCCTCCTCTGTCGTGGTGTCTGGCACCCCAATCCGAAGGCCCATGGGACAGATG
AAACCTGATGACTCTAAGCCTCCCGTATATGGTGCCTGCAAGCTCTTGGACATGGAGCTG
GAAATGGCTTTTTTTGTAGGCCCTGGAAACAGATTGGGAGAGCCGATCCCCATTTCCAAG
GCCCATGAGCACATTTTTGGAATGGTCCTTATGAACGACTGGAGTGCACGAGACATTCAG
AAGTGGGAGTATGTCCCTCTCGGGCCATTCCTTGGGAAGAGTTTTGGGACCACTGTCTCT
CCGTGGGTGGTGCCCATGGATGCTCTCATGCCCTTTGCTGTGCCCAACCCGAAGCAGGAC
CCCAGGCCCCTGCCGTATCTGTGCCATGACGAGCCCTACACATTTGACATCAACCTCTCT
GTTAACCTGAAAGGAGAAGGAATGAGCCAGGCGGCTACCATATGCAAGTCCAATTTTAAG
TACATGTACTGGACGATGCTGCAGCAGCTCACTCACCACTCTGTCAACGGCTGCAACCTG
CGGCCGGGGGACCTCCTGGCTTCTGGGACCATCAGCGGGCCGGAGCCAGAAAACTTCGGC
TCCATGTTGGAACTGTCGTGGAAGGGAACGAAGCCCATAGACCTGGGGAATGGTCAGACC
AGGAAGTTTCTGCTGGACGGGGATGAAGTCATCATAACAGGGTACTGCCAGGGGGATGGT
TACCGCATCGGCTTTGGCCAGTGTGCTGGAAAAGTGCTGCCTGCTCTCCTGCCATCATGA


# Metabolic_Enzyme_3_GenBank_ID_Gene:
M55150

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_3_Locus:
15q23-q25

# Metabolic_Enzyme_3_SNPs:
rs28733633; rs1801374; rs33929922; rs3189268; rs1049194; rs733679; rs2114716; rs2043692; rs1370276; rs1370274; rs3752692; rs12594576; rs2866591; rs4778758; rs1370273; rs1030865; rs8027831; rs8039712; rs7180031; rs2043691; rs8043131; rs8033974; rs10152142; rs2866592; rs8043254; rs11856427; rs2114706; rs7177977; rs1978817; rs2866593; rs2866594; rs2014531; rs7180267; rs1963890; rs1863768; rs11852901; rs2278205; rs2278204; rs6495477; rs1963889; rs1370277; rs4778583; rs1978816; rs1370275; rs12593746; rs12591114; rs3752693; rs6495478; rs7164048; rs11633719; rs1545119; rs16971777; rs2162550; rs16971784; rs11637869; rs7165316; rs6495476; rs13329170; rs12439250; rs17218165; rs12593304; rs12907580; rs17217997; rs11072883; rs3835063; rs12910663; rs12593724; rs12905358; rs12591184; rs7179137; rs8027913; rs11072882; rs12898576; rs16971779; rs7166889; rs11630172; rs7168949; rs2162552; rs11855351; rs8041120; rs11856039; rs8042782; rs11856087; rs11555097; rs11555096; rs34749737; rs1049165; rs35033541; rs36122289; rs3189275; rs1049181; rs3210172; rs3189271; rs1130438; rs34138675; rs12912992; rs12050831; rs28670686; rs34053230; rs35856260; rs3833032; rs28561542; rs10653816; rs7180879; rs35504528; rs12905208; rs7164212; rs2043693; rs11541885; rs11414483; rs28465485; rs35860708; rs10599000; rs28391413; rs35207990; rs3752694; rs12898575; rs28665646; rs34587722; rs34445460; rs11637479; rs35810566; rs3051263; rs35880073; rs8036972; rs35271165; rs8035131; rs28562328; rs7342660; rs3837742; rs28462237; rs34497292; rs28553552; rs35540542; rs9707913; rs12050830; rs9672598; rs11635433; rs12917072; rs11315019; rs34642735; rs34729999; rs28408765; rs34245126; rs35455610; rs35677503; rs1020056; rs11072885; rs11633099; rs12591328; rs12592943; rs12593705; rs12708527; rs12904314; rs1437221; rs1437222; rs16971826; rs1865998; rs34239630; rs35252136; rs4778757; rs4778760; rs713086; rs7172566; rs7174404; rs7175578; rs8025402; rs8026959; rs8040871; rs8041036

# Metabolic_Enzyme_3_General_References:
1998338; 2336361; 11278491; 9101289; 1401056; 8364576; 8318997; 7942842; 7977370; 8005583; 7757089; 7550234; 8557261; 9633815

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5800

# Metabolic_Enzyme_4_Name:
D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
BDH; 3-hydroxybutyrate dehydrogenase

# Metabolic_Enzyme_4_Gene_Name:
BDH1

# Metabolic_Enzyme_4_Protein_Sequence:
>Dbetahydroxybutyrate dehydrogenase, mitochondrial precursor
MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV
TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV
EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL
PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN
FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID
AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR

# Metabolic_Enzyme_4_Number_of_Residues:
343

# Metabolic_Enzyme_4_Molecular_Weight:
38158

# Metabolic_Enzyme_4_Theoretical_pI:
9.24

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH

# Metabolic_Enzyme_4_Pathway:
map00072  Synthesis and degradation of ketone bodies;
 map00650  Butanoate metabolism

# Metabolic_Enzyme_4_Reaction:
(R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.1.1.30

# Metabolic_Enzyme_4_GenBank_ID_Protein:
177198

# Metabolic_Enzyme_4_SwissProt_ID:
BDH_HUMAN (Q02338)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
BDH1

# Metabolic_Enzyme_4_Geneatlas_id:
BDH1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:1027

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_4_Gene_Sequence:
>1032 bp
GGCCTGCGGCCTCCGCCACCCGGACGCTTCTCACGGCTCCCAGGAAAAACCCTAAGTGCC
TGTGATAGAGAAAATGGAGCAAGACGCCCACTATTGCTTGGTTCTACTTCCTTTATCCCG
ATTGGCCGTCGGACTTATGCCAGTGCGGCGGAGCCGGTTGGCAGCAAAGCTGTCCTGGTC
ACAGGCTGTGACTCTGGATTTGGGTTCTCATTGGCCAAGCATCTGCATTCAAAAGGCTTC
CTTGTGTTTGCTGGCTGCTTGATGAAGGACAAAGGCCATGATGGGGTCAAGGAGCTGGAC
AGCCTAAACAGTGACCGATTGAGAACCGTCCAGCTCAATGTCTTCAGAAGCGAAGAGGTG
GAGAAAGTGGTGGGAGATTGTCCGTTCGAGCCTGAAGGACCTGAGAAAGGCATGTGGGGG
CTCGTTAACAATGCCGGCATCTCAACGTTCGGGGAGGTGGAGTTCACCAGCCTGGAGACC
TACAAGCAGGTGGCAGAAGTGAACCTTTGGGGCACAGTGCGGATGACGAAATCCTTTCTC
CCCCTCATCCGAAGGGCCAAAGGCCGCGTCGTCAATATCAGCAGCATGCTGGGCCGCATG
GCCAACCCGGCCCGCTCCCCGTACTGCATCACCAAGTTCGGGGTAGAGGCTTTCTCGGAC
TGCCTGCGCTATGAGATGTACCCCCTGGGCGTGAAGGTCAGCGTGGTGGAGCCCGGCAAC
TTCATCGCTGCCACCAGCCTTTACAACCCTGAGAGCATTCAGGCCATCGCCAAGAAGATG
TGGGAGGAGCTGCCTGAGGTCGTGCGCAAGGACTACGGCAAGAAGTACTTTGATGAAAAG
ATCGCCAAGATGGAGACCTACTGCAGCAGTGGCTCCACAGACACGTCCCCTGTCATCGAT
GCTGTCACACACGCCCTGACCGCCACCACCCCCTACACCCGCTACCACCCCATGGACTAC
TACTGGTGGCTGCGAATGCAGATCATGACCCACTTGCCTGGAGCCATCTCCGACATGATC
TACATCCGCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M93107

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_4_Locus:
3q29

# Metabolic_Enzyme_4_SNPs:
rs2116294; rs1050119; rs2686108; rs2686110; rs2163499; rs2567336; rs2567340; rs6786569; rs2567335; rs1966617; rs6583230; rs1966618; rs9879405; rs2567342; rs2163498; rs1367764; rs2116295; rs1808626; rs2567341; rs8034; rs7616534; rs7632731; rs6766998; rs6583229; rs8078; rs7621257; rs2567371; rs2567332; rs2116297; rs891668; rs11924432; rs2567339; rs2686107; rs13058963; rs11920698; rs6782014; rs13323537; rs9862739; rs2686106; rs2163500; rs6789469; rs2686101; rs2116293; rs2686109; rs9855602; rs9852958; rs11920608; rs2885274; rs6786459; rs11708643; rs9874314; rs11928702; rs9868824; rs13323565; rs11185474; rs6764170; rs6583226; rs12718046; rs1549830; rs2686068; rs7617106; rs2099248; rs4374547; rs7616998; rs4857504; rs4857524; rs2885271; rs7651427; rs9325394; rs6806696; rs6777785; rs13077136; rs7649784; rs4857525; rs4476524; rs9868761; rs11915185; rs13073953; rs13097456; rs3828369; rs7620153; rs2686065; rs9325395; rs11915129; rs11925979; rs7649797; rs2484; rs2099247; rs7642375; rs2082268; rs2567331; rs13061303; rs2686095; rs13076273; rs2567330; rs6808480; rs2483; rs2567327; rs11919480; rs13083797; rs6583225; rs6777664; rs7638381; rs6583224; rs11716168; rs13095317; rs11924089; rs7649964; rs4857505; rs6777559; rs4857523; rs7641933; rs13326190; rs4857527; rs10084709; rs11718875; rs13093836; rs11914879; rs4473573; rs11919456; rs11919153; rs13318063; rs2303981; rs13324185; rs13058936; rs7614448; rs2567329; rs7631626; rs2686072; rs7628668; rs2060082; rs6786074; rs2567369; rs2060083; rs2686111; rs2060086; rs6583231; rs7642233; rs7428150; rs7642209; rs2686071; rs2567367; rs2060084; rs2060085; rs2567368; rs7639745; rs4857528; rs7653275; rs17850831; rs35089738; rs4507277; rs35660426; rs6768540; rs7627975; rs35113035; rs9820760; rs2567338; rs2567370; rs1358; rs35636337; rs3061417; rs35077721; rs35659266; rs7611478; rs35299784; rs34775656; rs34350299; rs7635416; rs2567337; rs3214596; rs7626667; rs13088613; rs35152240; rs34654706; rs6808852; rs9820761; rs35044509; rs6768543; rs35080626; rs28647831; rs2885273; rs35415239; rs4574319; rs35008113; rs34909084; rs28412749; rs13062005; rs2686069; rs35140312; rs13076254; rs9878662; rs9819231; rs6769884; rs34951456; rs34469658; rs6781050; rs35599589; rs11553758; rs11373347; rs4507278; rs13080421; rs34896259; rs11928460; rs4279121; rs2116296; rs35613212; rs35181583; rs13062106; rs2686070; rs11553757; rs35345630; rs34171945; rs35975225; rs13099517; rs35012311; rs9825388; rs34400011; rs34640900; rs2686091; rs3951810; rs34430794; rs13062462; rs34919401; rs2567328; rs13086723; rs34337317; rs7615878; rs34255245; rs9873526; rs4857503; rs13091363; rs4998964; rs3061411; rs13086928; rs13087821; rs2686066; rs13072230; rs35165087; rs34717534; rs13088545; rs13071830; rs2009794; rs13085085; rs13062281; rs12639002; rs5855648; rs13078323; rs34549679; rs35307759; rs34539371; rs13062463; rs3762651; rs2567326; rs10212317; rs4024114; rs35896310; rs13075081; rs11285275; rs34006597; rs34584547; rs35959915; rs9832212; rs5017759; rs13062112; rs35414948; rs13081904; rs11923999; rs13068777; rs34708637; rs34985296; rs11375545; rs6792458; rs35643475; rs34005222; rs28447027; rs13062318; rs34621227; rs34799612; rs35185426; rs13100382; rs1062166; rs13072037; rs13096090; rs35359187; rs4588382; rs9828921; rs13093630; rs34231396; rs13083843; rs1978669; rs4024112; rs6770889; rs34323761; rs35911854; rs13085264; rs13093491; rs2163497; rs13089414; rs7631813; rs11292639; rs6762077; rs1030575; rs1030576; rs11706285; rs11711217; rs11718807; rs11920279; rs11922199; rs13319572; rs1864667; rs1864668; rs1864671; rs2567366; rs2686076; rs2686096; rs2686097; rs4482680; rs6583235; rs6583236; rs6781945; rs6782341; rs6790736; rs6807125; rs7610767; rs7610849; rs7618498; rs9816968; rs9837840; rs9844937; rs9878188

# Metabolic_Enzyme_4_General_References:
1639787

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5988

# Metabolic_Enzyme_5_Name:
Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
Testis-specific succinyl CoA:3-oxoacid CoA- transferase; SCOT-t

# Metabolic_Enzyme_5_Gene_Name:
OXCT2

# Metabolic_Enzyme_5_Protein_Sequence:
>SuccinylCoA:3ketoacidcoenzyme A transferase 2, mitochondrial precursor
MAALRLLASVLGRGVPAGGSGLALSQGCARCFATSPRLRAKFYADPVEMVKDISDGATVM
IGGFGLCGIPENLIAALLRTRVKDLQVVSSNVGVEDFGLGLLLAARQVRRIVCSYVGENT
LCESQYLAGELELELTPQGTLAERIRAGGAGVPAFYTPTGYGTLVQEGGAPIRYTPDGHL
ALMSQPREVREFNGDHFLLERAIRADFALVKGWKADRAGNVVFRRSARNFNVPMCKAADV
TAVEVEEIVEVGAFPPEDIHVPNIYVDRVIKGQKYEKRIERLTILKEEDGDAGKEEDART
RIIRRAALEFEDGMYANLGIGIPLLASNFISPSMTVHLHSENGILGLGPFPTEDEVDADL
INAGKQTVTVLPGGCFFASDDSFAMIRGGHIQLTMLGAMQVSKYGDLANWMIPGKKVKGM
GGAMDLVSSQKTRVVVTMQHCTKDNTPKIMEKCTMPLTGKRCVDRIITEKAVFDVHRKKE
LTLRELWEGLTVDDIKKSTGCAFAVSPNLRPMQQVAP

# Metabolic_Enzyme_5_Number_of_Residues:
517

# Metabolic_Enzyme_5_Molecular_Weight:
56141

# Metabolic_Enzyme_5_Theoretical_pI:
7.15

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  CoA-transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate

# Metabolic_Enzyme_5_Pathway:
map00072  Synthesis and degradation of ketone bodies;
 map00280  Valine, leucine and isoleucine degradation;
 map00650  Butanoate metabolism

# Metabolic_Enzyme_5_Reaction:
succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01144:CoA_trans

# Metabolic_Enzyme_5_Signals:
1-21

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.8.3.5

# Metabolic_Enzyme_5_GenBank_ID_Protein:
118026874

# Metabolic_Enzyme_5_SwissProt_ID:
SCOT2_HUMAN (Q9BYC2)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
OXCT2

# Metabolic_Enzyme_5_Geneatlas_id:
OXCT2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:18606

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_5_Gene_Sequence:
>1554 bp
ATGGCGGCGCTGCGGCTCCTGGCGTCAGTGCTCGGGCGCGGGGTCCCCGCCGGCGGCTCA
GGGCTCGCGCTGTCCCAGGGCTGCGCCCGCTGCTTTGCCACCAGTCCCCGGCTCCGTGCC
AAGTTCTACGCGGACCCGGTGGAGATGGTGAAGGACATCTCTGACGGGGCGACCGTCATG
ATCGGGGGCTTCGGGCTCTGCGGGATCCCCGAGAACCTGATCGCCGCGCTGCTCAGGACC
CGCGTGAAAGACCTGCAGGTGGTCAGCAGCAACGTGGGCGTGGAGGACTTCGGCCTGGGC
CTCCTGCTGGCCGCCAGGCAGGTCCGTCGCATCGTCTGTTCCTACGTGGGCGAGAACACC
CTGTGCGAGAGCCAGTACCTGGCAGGAGAGCTGGAGCTGGAGCTCACGCCCCAGGGCACC
CTGGCCGAGCGCATCCGCGCGGGGGGCGCCGGGGTGCCCGCCTTCTACACCCCCACGGGC
TACGGGACCCTGGTCCAGGAAGGGGGCGCCCCCATCCGCTACACCCCGGACGGCCACCTG
GCGCTCATGAGCCAGCCCCGAGAGGTGAGGGAGTTCAACGGCGACCACTTCCTTTTGGAG
CGCGCCATCCGGGCAGACTTCGCCCTGGTGAAAGGGTGGAAGGCCGACCGGGCAGGAAAC
GTGGTCTTCAGGAGAAGCGCCCGCAATTTCAACGTGCCCATGTGCAAAGCTGCAGACGTC
ACGGCGGTGGAGGTGGAAGAGATCGTGGAGGTGGGGGCTTTCCCCCCAGAAGACATCCAC
GTTCCTAACATTTATGTAGATCGCGTGATAAAGGGGCAGAAATACGAGAAACGAATTGAG
CGCTTAACGATCCTGAAAGAGGAAGATGGAGACGCTGGAAAGGAAGAGGACGCCAGGACG
CGCATCATCAGACGCGCAGCTCTGGAATTTGAGGACGGCATGTACGCCAATCTGGGCATA
GGCATCCCCCTGCTGGCCAGCAACTTCATCAGTCCCAGCATGACTGTCCATCTTCACAGT
GAGAACGGGATCCTGGGCCTGGGCCCGTTTCCCACGGAAGATGAGGTGGATGCCGACCTC
ATCAATGCAGGCAAGCAGACGGTCACGGTGCTTCCCGGGGGCTGCTTCTTCGCCAGCGAC
GACTCCTTCGCCATGATCCGAGGGGGACACATCCAACTAACCATGCTTGGAGCCATGCAG
GTTTCCAAATACGGCGACCTGGCGAACTGGATGATCCCTGGCAAGAAGGTGAAAGGCATG
GGCGGTGCCATGGACTTGGTGTCCAGTCAGAAGACCAGAGTGGTGGTCACCATGCAGCAC
TGCACAAAGGACAACACCCCCAAGATCATGGAGAAATGCACCATGCCGCTGACCGGGAAG
CGGTGCGTGGACCGCATCATCACCGAGAAGGCCGTGTTTGACGTGCACAGGAAGAAAGAG
CTGACGCTGAGGGAGCTCTGGGAGGGCCTGACGGTGGACGACATCAAAAAGAGCACGGGG
TGTGCCTTTGCTGTGTCCCCGAACCTCAGGCCCATGCAGCAGGTGGCACCCTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AB050193

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_5_Locus:
1p34

# Metabolic_Enzyme_5_SNPs:
Not Available

# Metabolic_Enzyme_5_General_References:
Not Available

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
6878

# Metabolic_Enzyme_6_Name:
Catalase

# Metabolic_Enzyme_6_Synonyms:
Not Available

# Metabolic_Enzyme_6_Gene_Name:
CAT

# Metabolic_Enzyme_6_Protein_Sequence:
>Catalase
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT
KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD
THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE
HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK
NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL

# Metabolic_Enzyme_6_Number_of_Residues:
527

# Metabolic_Enzyme_6_Molecular_Weight:
59757

# Metabolic_Enzyme_6_Theoretical_pI:
7.41

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  catalase activity
 ||
>>>
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide

# Metabolic_Enzyme_6_Pathway:
map00380  Tryptophan metabolism;
 map00680  Methane metabolism

# Metabolic_Enzyme_6_Reaction:
2 H2O2 = O2 + 2 H2O

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00199:Catalase

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.11.1.6

# Metabolic_Enzyme_6_GenBank_ID_Protein:
1228085

# Metabolic_Enzyme_6_SwissProt_ID:
CATA_HUMAN (P04040)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
CAT

# Metabolic_Enzyme_6_Geneatlas_id:
CAT

# Metabolic_Enzyme_6_hgnc_id:
HGNC:1516

# Metabolic_Enzyme_6_PDB_ID:
1F4J

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_6_Gene_Sequence:
>66 bp
ATGGCTGACAGCCGGGATCCCGCCAGCGACCAGATGCAGCACTGGAAGGAGCAGCGGGCC
GCGCAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
X04085

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_6_Locus:
11p13

# Metabolic_Enzyme_6_SNPs:
rs17880442; rs11032709; rs769217; rs35677492; rs1049982; rs2234940; rs1050032; rs566979; rs769218; rs511895; rs524167; rs494024; rs1408035; rs560807; rs10488736; rs2284367; rs482322; rs7947841; rs480496; rs11032699; rs2300182; rs2284365; rs7103083; rs499406; rs3758730; rs4755372; rs508370; rs7933285; rs1000343; rs554576; rs2073059; rs11032701; rs17886008; rs4755373; rs484214; rs6484722; rs543701; rs17884666; rs2420389; rs551929; rs480575; rs10836244; rs2179625; rs7113917; rs2268063; rs533425; rs12272630; rs17881488; rs486256; rs17884576; rs2073058; rs11604331; rs17884491; rs7120960; rs1408034; rs524154; rs7109778; rs7101395; rs17881288; rs12269988; rs7126610; rs10836235; rs16925608; rs16925614; rs11824384; rs2284368; rs17883121; rs2420388; rs4756146; rs16925606; rs17884086; rs2284364; rs7930427; rs12803540; rs1408036; rs17268652; rs2284366; rs17881567; rs2300181; rs7928213; rs11032702; rs16925581; rs525938; rs11032700; rs17881921; rs17884095; rs17885743; rs17881476; rs17883793; rs11826620; rs12270780; rs35915891; rs2268064; rs17883592; rs17884725; rs17881482; rs17880673; rs2284369; rs17883544; rs11032703; rs12273124; rs17884248; rs35755143; rs7126640; rs2076556; rs4755374; rs1055981; rs17884335; rs17884518; rs17880274; rs17883699; rs4756148; rs17886200; rs475043; rs564250; rs769214; rs9282626; rs7943316; rs9282627; rs7104301; rs17883920; rs1001179; rs17881029; rs17886350; rs2266625; rs34455645; rs3180560; rs11546300; rs1050028; rs2266629; rs2266619; rs14527; rs2266628; rs35012776; rs34964953; rs34727149; rs3831770; rs17886810; rs35927227; rs7121850; rs17885881; rs17882812; rs17885837; rs17880607; rs17882039; rs17881916; rs17880549; rs34138762; rs28586982; rs34503767; rs36074933; rs515130; rs35099202; rs35849009; rs17881846; rs17887048; rs17881224; rs17884421; rs34840731; rs17881231; rs35340649; rs35292563; rs17884242; rs12286702; rs35034960; rs28733253; rs17887248; rs35791482; rs35703808; rs35648206; rs34808995; rs35386961; rs34420404; rs856714; rs17883483; rs17884804; rs17883367; rs17883534; rs17880160; rs17886672; rs34281397; rs34790990; rs2982523; rs35122257; rs2284370; rs12798927; rs35781217; rs11032707; rs17886592; rs4483566; rs34890123; rs4272763; rs12789374; rs17881734; rs35330036; rs17883434; rs35081167; rs17886155; rs17886248; rs34840787; rs34890990; rs17881192; rs17881586; rs34267165; rs12786539; rs35834969; rs3818354; rs17884443; rs36224415; rs36224416; rs36224102; rs10312; rs10836230; rs10836233; rs10836234; rs11032717; rs1107573; rs11606946; rs12284341; rs12807961; rs12808450; rs1323690; rs1535718; rs1535719; rs1535720; rs1535721; rs16925525; rs2073057; rs208678; rs208679; rs208681; rs208682; rs208683; rs2231828; rs2266624; rs2266630; rs2296144; rs409598; rs554518; rs7109862; rs7114869; rs7118388; rs7928156; rs7941147; rs7944397; rs7949972

# Metabolic_Enzyme_6_General_References:
3755525; 3755526; 11728823; 8282800; 12665801; 6548744; 10666617; 10656833; 11134921

# Metabolic_Enzyme_6_References:
12869369; 15723974

# Metabolic_Enzyme_7_ID:
8620

# Metabolic_Enzyme_7_Name:
Hypothetical protein

# Metabolic_Enzyme_7_Synonyms:
Not Available

# Metabolic_Enzyme_7_Gene_Name:
Not Available

# Metabolic_Enzyme_7_Protein_Sequence:
>Hypothetical protein
NWKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYG
MGCYEISLGD
TIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGI
NVVDSAVSGLGGCPYAKGASG
NVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNK
TTNSKVAQASFNA

# Metabolic_Enzyme_7_Number_of_Residues:
191

# Metabolic_Enzyme_7_Molecular_Weight:
20209

# Metabolic_Enzyme_7_Theoretical_pI:
7.27

# Metabolic_Enzyme_7_GO_Classification:
>>>
 Function:  catalytic activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Amino acid transport and metabolism

# Metabolic_Enzyme_7_Specific_Function:
Not Available

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
Not Available

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00682:HMGL-like

# Metabolic_Enzyme_7_Signals:
Not Available

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 4.1.3.4

# Metabolic_Enzyme_7_GenBank_ID_Protein:
4406665

# Metabolic_Enzyme_7_SwissProt_ID:
O95896_HUMAN (O95896)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
Not Available

# Metabolic_Enzyme_7_Geneatlas_id:
Not Available

# Metabolic_Enzyme_7_hgnc_id:
HGNC:21359

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>576 bp

AACTGGAAGAATATTAACTGTTCCATTGAAGAAAGTATGGGAAAATTTGAGGAGGTTGT
TAAGTCTGCAA
GACACATGAATATTCCAGCACGAGGGTATGTGTCTTGTGCTCTGGGCT
GTCCATATGAAGGAAGTATTAC
ACCGCAAAAAGTGACAGAAGTGTCTAAGAGATTGTAC
GGCATGGGTTGTTATGAGATCTCTCTAGGAGAC
ACAATTGGAGTGGGAACTCCAGGAAG
TATGAAAAGAATGTTGGAAAGTGTGATGAAAGAAATCCCACCAG
GTGCTCTTGCTGTTC
ACTGTCATGACACATACGGACAAGCCTTAGCAAATATCCTTACGGCCCTTCAGAT
GGGA
ATTAATGTGGTGGACTCCGCAGTATCCGGATTAGGTGGCTGCCCTTATGCAAAAGGTGCT
TCTGGG
AATGTAGCCACTGAGGATTTGATATATATGCTTAATGGCCTGGGGCTCAATAC
AGGTGTGAATCTATACA
AAGTGATGGAAGCTGGTGACTTTATTTGCAAAGCTGTGAATA
AAACCACAAACTCTAAAGTAGCACAAGC
CTCCTTCAATGCTTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AF131827

# Metabolic_Enzyme_7_Chromosome_Location:
Not Available

# Metabolic_Enzyme_7_Locus:
Not Available

# Metabolic_Enzyme_7_SNPs:
Not Available

# Metabolic_Enzyme_7_General_References:
8619474; 9110174

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
8700

# Metabolic_Enzyme_8_Name:
Hypothetical protein DKFZp666F229

# Metabolic_Enzyme_8_Synonyms:
Not Available

# Metabolic_Enzyme_8_Gene_Name:
DKFZp666F229

# Metabolic_Enzyme_8_Protein_Sequence:
>Hypothetical protein DKFZp666F229
DDLYHWSVESYSDFWAEFWKFSGIVFSRVYDEVVDTSKGIADVPEWFKGSRLNYAENLLR
HKENDRVALYIAREGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGDRVVGYLPNSEHAV
EAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHNHMEKLQQVV
KGLPDLKKVVVIPYVSSRENIDLSKIPNSVFLDDFLATGTSEQAPQLEFEQLPFSHPLFI
MFSSGTTGAPKCMVHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVGWMMWNWMVSLLAT
GAAMVLYDGSPLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEEKAMKPVETHSLQMLHTI
LSTGSPLKAQSYEYVYRCIKSSILLGSISGGTDIISCFMGHNFSLPVYKGEIQARNLGMA
VEAWNEEGKAVWGESGELVCTKPIPCQPTHFWNDENGNKYRKAYFSKFPGIWAHGDYCRI
NPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERVILFL
KMASGHAFQPDLVKRIRDAIRMGLSARHVPSLILETKGIPYTLNGKKVEVAVKQIIAGKA
VEQGGAFSNPETLDLYRDIPELQGF

# Metabolic_Enzyme_8_Number_of_Residues:
625

# Metabolic_Enzyme_8_Molecular_Weight:
69801

# Metabolic_Enzyme_8_Theoretical_pI:
6.37

# Metabolic_Enzyme_8_GO_Classification:
>>>
 Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-sulfur bonds
Function:  CoA-ligase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  isoprenoid metabolism
Process:  isoprenoid biosynthesis
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Lipid transport and metabolism

# Metabolic_Enzyme_8_Specific_Function:
Not Available

# Metabolic_Enzyme_8_Pathway:
Not Available

# Metabolic_Enzyme_8_Reaction:
Not Available

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_8_Signals:
1-303

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 6.2.1.16

# Metabolic_Enzyme_8_GenBank_ID_Protein:
52545788

# Metabolic_Enzyme_8_SwissProt_ID:
Q658Q8_HUMAN (Q658Q8)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
DKFZp666F229

# Metabolic_Enzyme_8_Geneatlas_id:
DKFZp666F229

# Metabolic_Enzyme_8_hgnc_id:
HGNC:21298

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Not Available

# Metabolic_Enzyme_8_Gene_Sequence:
>1878 bp
GATGACTTGTACCATTGGTCCGTTGAGTCATATTCAGACTTCTGGGCAGAGTTCTGGAAA
TTCAGTGGAATTGTCTTCTCACGTGTGTATGATGAGGTTGTGGACACATCGAAAGGAATC
GCAGATGTCCCCGAGTGGTTCAAAGGCAGTCGGCTCAACTATGCAGAAAACCTCCTGCGG
CACAAAGAGAATGACAGAGTTGCCCTTTACATTGCAAGGGAAGGCAAAGAGGAAATTGTG
AAGGTGACTTTTGAAGAGCTGAGGCAAGAAGTGGCTTTGTTTGCAGCAGCAATGAGGAAA
ATGGGTGTGAAGAAAGGAGATCGGGTTGTTGGTTATTTACCCAACAGTGAGCACGCTGTC
GAGGCGATGCTGGCTGCGGCAAGCATTGGTGCCATCTGGAGCTCCACGTCCCCGGACTTC
GGTGTGAATGGTGTGCTGGACCGGTTTTCTCAAATTCAGCCAAAGCTCATCTTCTCTGTG
GAGGCTGTTGTCTATAATGGCAAAGAGCACAACCACATGGAAAAGCTGCAGCAGGTGGTT
AAAGGCCTACCAGACTTGAAGAAAGTGGTGGTGATTCCTTATGTGTCCTCCAGAGAGAAC
ATAGACCTTTCAAAGATTCCAAACAGTGTGTTTCTGGATGACTTTCTTGCCACCGGCACC
AGTGAGCAGGCCCCGCAGCTGGAGTTCGAGCAGCTGCCCTTCAGCCACCCACTGTTCATC
ATGTTCTCATCGGGCACCACGGGCGCACCCAAGTGCATGGTGCATTCCGCTGGGGGCACC
CTCATCCAGCATCTGAAGGAGCACCTGCTGCACGGCAACATGACCAGCAGTGACATCCTC
CTGTGCTACACCACGGTCGGCTGGATGATGTGGAACTGGATGGTGTCCCTTCTGGCCACA
GGAGCGGCCATGGTCTTGTACGATGGCTCCCCCCTGGTGCCCACGCCCAATGTGCTCTGG
GACCTGGTTGACAGGATAGGCATCACTGTCCTGGTAACTGGGGCCAAGTGGCTGTCAGTG
CTGGAAGAGAAGGCCATGAAGCCGGTGGAAACCCACAGTCTCCAGATGCTCCACACGATC
CTGTCCACTGGCTCCCCACTGAAAGCCCAGAGCTACGAGTATGTCTACAGGTGCATCAAG
AGCAGCATCCTCCTGGGCTCCATCTCAGGAGGCACCGACATCATCTCCTGCTTCATGGGC
CACAATTTTTCTCTTCCTGTGTATAAAGGGGAGATTCAGGCCCGGAACCTGGGCATGGCC
GTGGAAGCGTGGAACGAGGAAGGAAAGGCGGTCTGGGGAGAGAGCGGCGAGCTGGTGTGT
ACTAAGCCGATCCCTTGCCAGCCCACACACTTCTGGAACGATGAGAACGGCAACAAGTAC
AGGAAGGCGTATTTCTCCAAATTCCCAGGTATCTGGGCTCATGGCGACTACTGCAGAATC
AACCCCAAGACCGGGGGCATCGTCATGCTTGGCCGGAGTGACGGCACCCTCAACCCCAAC
GGGGTGCGGTTCGGCAGCTCGGAAATCTATAACATTGTGGAATCCTTCGAGGAGGTGGAG
GACAGCCTGTGTGTCCCCCAGTATAACAAGTACAGGGAGGAGAGGGTGATCCTCTTCCTG
AAGATGGCCTCCGGGCACGCCTTCCAGCCTGACTTGGTTAAGAGGATCCGTGACGCCATC
CGCATGGGCTTGTCTGCGCGACACGTGCCCAGCCTCATCCTGGAAACCAAGGGCATCCCG
TATACGCTCAACGGCAAGAAAGTGGAAGTTGCCGTCAAACAGATCATCGCTGGAAAAGCC
GTGGAGCAAGGAGGTGCTTTCTCGAACCCCGAGACCCTGGATCTGTACCGGGACATCCCT
GAGCTGCAGGGCTTCTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
AL833047

# Metabolic_Enzyme_8_Chromosome_Location:
Not Available

# Metabolic_Enzyme_8_Locus:
Not Available

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
Not Available

# Metabolic_Enzyme_8_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7549

# Macromolecular_Interacting_Partner_1_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
INS

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_1_Signals:
1-24

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
INS

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11p15.5

# Macromolecular_Interacting_Partner_1_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_1_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_1_References:
12145163; 12604674; 15104240

# Macromolecular_Interacting_Partner_2_ID:
7588

# Macromolecular_Interacting_Partner_2_Name:
Annexin A5

# Macromolecular_Interacting_Partner_2_Synonyms:
Annexin V; Lipocortin V; Endonexin II; Calphobindin I; CBP-I; Placental anticoagulant protein I; PAP-I; PP4; Thromboplastin inhibitor; Vascular anticoagulant-alpha; VAC-alpha; Anchorin CII

# Macromolecular_Interacting_Partner_2_Gene_Name:
ANXA5

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Annexin A5
MAQVLRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTL
FGRDLLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPE
ELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDPDAGIDEAQVEQDAQALF
QAGELKWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAV
VKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMI
KGDTSGDYKKALLLLCGEDD

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
320

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
35937

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
4.66

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  lipid binding
Function:  phospholipid binding
Function:  calcium-dependent phospholipid binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  regulation of biological process
Process:  negative regulation of biological process
Process:  negative regulation of physiological process
Process:  negative regulation of coagulation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00191:Annexin

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
179132

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
ANXA5_HUMAN (P08758)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
ANXA5

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
ANXA5

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:543

# Macromolecular_Interacting_Partner_2_PDB_ID:
1HAK

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>963 bp
ATGGCACAGGTTCTCAGAGGCACTGTGACTGACTTCCCTGGATTTGATGAGCGGGCTGAT
GCAGAAACTCTTCGGAAGGCTATGAAAGGCTTGGGCACAGATGAGGAGAGCATCCTGACT
CTGTTGACATCCCGAAGTAATGCTCAGCGCCAGGAAATCTCTGCAGCTTTTAAGACTCTG
TTTGGCAGGGATCTTCTGGATGACCTGAAATCAGAACTAACTGGAAAATTTGAAAAATTA
ATTGTGGCTCTGATGAAACCCTCTCGGCTTTATGATGCTTATGAACTGAAACATGCCTTG
AAGGGAGCTGGAACAAATGAAAAAGTACTGACAGAAATTATTGCTTCAAGGACACCTGAA
GAACTGAGAGCCATCAAACAAGTTTATGAAGAAGAATATGGCTCAAGCCTGGAAGATGAC
GTGGTGGGGGACACTTCAGGGTACTACCAGCGGATGTTGGTGGTTCTCCTTCAGGCTAAC
AGAGACCCTGATGCTGGAATTGATGAAGCTCAAGTTGAACAAGATGCTCAGGCTTTATTT
CAGGCTGGAGAACTTAAATGGGGGACAGATGAAGAAAAGTTTATCACCATCTTTGGAACA
CGAAGTGTGTCTCATTTGAGAAAGGTGTTTGACAAGTACATGACTATATCAGGATTTCAA
ATTGAGGAAACCATTGACCGCGAGACTTCTGGCAATTTAGAGCAACTACTCCTTGCTGTT
GTGAAATCTATTCGAAGTATACCTGCCTACCTTGCAGAGACCCTCTATTATGCTATGAAG
GGAGCTGGGACAGATGATCATACCCTCATCAGAGTCATGGTTTCCAGGAGTGAGATTGAT
CTGTTTAACATCAGGAAGGAGTTTAGGAAGAATTTTGCCACCTCTCTTTATTCCATGATT
AAGGGAGATACATCTGGGGACTATAAGAAAGCTCTTCTGCTGCTCTGTGGAGAAGATGAC
TAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M18366

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_2_Locus:
4q26-q28|4q28-q32

# Macromolecular_Interacting_Partner_2_SNPs:
rs17718; rs1050606; rs9611; rs11575945; rs6830321; rs4240260; rs6823422; rs3756281; rs6845202; rs6534313; rs3733650; rs6534309; rs12649582; rs12510548; rs12511956; rs17450274; rs2306412; rs9685230; rs2306413; rs11731225; rs11098638; rs4326032; rs3733649; rs4833229; rs17449954; rs2306419; rs2306421; rs2306411; rs1480287; rs10518391; rs11932858; rs6857766; rs1383232; rs6854854; rs2306416; rs11726034; rs3756282; rs13136094; rs17051385; rs6851541; rs13111903; rs6534311; rs13120425; rs13145977; rs11942224; rs17384348; rs6534310; rs17051389; rs2306418; rs17051384; rs2306414; rs6841077; rs11098637; rs7686966; rs2306420; rs2306415; rs10006927; rs17051387; rs7660705; rs13122280; rs6534312; rs13151539; rs17051386; rs13109053; rs12645651; rs6848019; rs2127644; rs7676539; rs17851665; rs11538100; rs41278081; rs1480274; rs11538101; rs17851664; rs1804120; rs11538102; rs28651243; rs34122352; rs10019175; rs17384579; rs35031093; rs3214942; rs34386777; rs17051388; rs10034288; rs41278075; rs33997026; rs3836727; rs5861534; rs28557003; rs34674339; rs13148862; rs34945219; rs10680099; rs6843558; rs2306417; rs6818227; rs35955322; rs28453127; rs6848645; rs7675369; rs35112112; rs4833756; rs35218735; rs9995591; rs10006900; rs41278083; rs10008778; rs33971134; rs5861533; rs28695699; rs34828556; rs35843876; rs9995406; rs41278079; rs28454132; rs34881128; rs33915237; rs35301456; rs36067198; rs41279317; rs34447443; rs35147940; rs10017443; rs28602805; rs35381678; rs34303326; rs9998908; rs35912228; rs13121588; rs36114805; rs35121623; rs28493177; rs5000905; rs34818442; rs35904748; rs2390229; rs7440751; rs6842386; rs6534308; rs41278077; rs10008313; rs35999558; rs33973673; rs35635288; rs35317464; rs11724110; rs35470966; rs17551751; rs34838306; rs35292405; rs9995117; rs34707920; rs28717001; rs3756283; rs9995119; rs10011722; rs11098632; rs11098633; rs11098634; rs13137821; rs1552069; rs17384008; rs2892948; rs2892949; rs6855512; rs7655436; rs7680787; rs9995019

# Macromolecular_Interacting_Partner_2_General_References:
2964863; 2963810; 2455636; 2967291; 2968983; 2967495; 7958998; 8034319; 2532007; 2957692; 2974032; 2147412; 2148156; 1311770; 9398511; 9435213

# Macromolecular_Interacting_Partner_2_References:
12410563; 16652187

# Macromolecular_Interacting_Partner_3_ID:
8452

# Macromolecular_Interacting_Partner_3_Name:
Lymphotoxin-beta

# Macromolecular_Interacting_Partner_3_Synonyms:
LT-beta; Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3

# Macromolecular_Interacting_Partner_3_Gene_Name:
LTB

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Lymphotoxinbeta
MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD
PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS
DAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLE
GAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGA
VMVG

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
244

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
25390

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
5.02

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_3_Signals:
1-35

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
292279

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
TNFC_HUMAN (Q06643)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
LTB

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
LTB

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:6711

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>735 bp
ATGGGGGCACTGGGGCTGGAGGGCAGGGGTGGGAGGCTCCAGGGGAGGGGTTCCCTCCTG
CTAGCTGTGGCAGGAGCCACTTCTCTGGTGACCTTGTTGCTGGCGGTGCCTATCACTGTC
CTGGCTGTGCTGGCCTTAGTGCCCCAGGATCAGGGAGGACTGGTAACGGAGACGGCCGAC
CCCGGGGCACAGGCCCAGCAAGGACTGGGGTTTCAGAAGCTGCCAGAGGAGGAGCCAGAA
ACAGATCTCAGCCCCGGGCTCCCAGCTGCCCACCTCATAGGCGCTCCGCTGAAGGGGCAG
GGGCTAGGCTGGGAGACGACGAAGGAACAGGCGTTTCTGACGAGCGGGACGCAGTTCTCG
GACGCCGAGGGGCTGGCGCTCCCGCAGGACGGCCTCTATTACCTCTACTGTCTCGTCGGC
TACCGGGGCCGGGCGCCCCCTGGCGGCGGGGACCCCCAGGGCCGCTCGGTCACGCTGCGC
AGCTCTCTGTACCGGGCGGGGGGCGCCTACGGGCCGGGCACTCCCGAGCTGCTGCTCGAG
GGCGCCGAGACGGTGACTCCAGTGCTGGACCCGGCCAGGAGACAAGGGTACGGGCCTCTC
TGGTACACGAGCGTGGGGTTCGGCGGCCTGGTGCAGCTCCGGAGGGGCGAGAGGGTGTAC
GTCAACATCAGTCACCCCGATATGGTGGACTTCGCGAGAGGGAAGACCTTCTTTGGGGCC
GTGATGGTGGGGTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
L11016

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_3_Locus:
6p21.3

# Macromolecular_Interacting_Partner_3_SNPs:
Not Available

# Macromolecular_Interacting_Partner_3_General_References:
7916655; 9299492; 10202016

# Macromolecular_Interacting_Partner_3_References:
12799038

End of HMDB00060

Beginning of HMDB00061
# Accession_No:
HMDB00061

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-09 14:05:54

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Adenosine 3',5'-diphosphate

# Description:
Adenosine 3', 5'-diphosphate or PAP is a nucleotide that is closely related to ADP. It has two phosphate groups attached to the 5' and 3' positions of the pentose sugar ribose (instead of pyrophosphoric acid at the 5' position, as found in ADP), and the nucleobase adenine. PAP is converted to PAPS by Sulfotransferase and then back to PAP after the sulfotransferase reaction.  Sulfotransferase (STs) catalyze the transfer reaction of the sulfate group from the ubiquitous donor 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to an acceptor group of numerous substrates. This reaction, often referred to as sulfuryl transfer, sulfation, or sulfonation, is widely observed from bacteria to humans and plays a key role in various biological processes such as cell communication, growth and development, and defense.  PAP also appears to a role in bipolar depression.  Phosphatases converting 3'-phosphoadenosine 5'-phosphate (PAP) into adenosine 5'-phosphate are of fundamental importance in living cells as the accumulation of PAP is toxic to several cellular systems. These enzymes are lithium-sensitive and we have characterized a human PAP phosphatase as a potential target of lithium therapy.

# Synonyms:
3,5-Diphosphoadenosine; 3,5-ADP; 3-Phosphoadenosine 5-phosphate; 3'-Phosphoryl-AMP; 5-(dihydrogen phosphate) 3-Adenylate; 5-(dihydrogen phosphate)3'-Adenylic acid; Adenosine 3,5-bis; Adenosine 3,5-bisphosphate; Adenosine 3,5-diphosphic acid

# Chemical_IUPAC_Name:
[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-oxolan-2-yl]methoxyphosphonic acid

# Chemical_Formula:
C10H15N5O10P2

# Chemical_Structure:
tbl_chemical:::HMDB00061_ZOOM.png:::11928316521823564

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00061_THUMB.png:::119283165009732511

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; secondary alcohol; primary amine; primary aromatic amine; phosphoric acid ester; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of Androgen and estrogen metabolism; Component of Chondroitin / Heparan sulfate biosynthesis; Component of Glycosphingolipid metabolism; Component of Sulfur metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
427.02942

# Molecular_Weight_Avg:
427.20111

# Smiles_String_isomeric:
NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](COP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]3O

# Smiles_String_canonical:
NC1=NC=NC2=C1N=CN2C3OC(COP(O)(O)=O)C(OP(O)(O)=O)C3O

# KEGG_Compound_ID:
C00054

# BioCyc_ID:
3-5-ADP

# PubChem_CID:
159296

# PubChem_SID:
836671; 819486; 583956; 8028478; 6436350; 824149; 583951; 8028359; 11531972; 7978620; 819501; 827913; 11531970; 736736; 821837; 820093; 854590; 11539079; 854592; 584924; 8026220; 854587; 819851; 7885589; 825955; 10253558; 830016; 830020; 830017; 820356; 819849; 830011; 828813; 8144866; 833951; 825211; 3356; 11532799; 828112; 838235

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
33684

# Wikipedia_ID:
Not Available

# METLIN_ID:
Not Available

# Ref_ID:
10752640; 11415433; 14573867; 11719372; 7877593; 8570639

# ChEBI_ID:
17985

# CAS_Registry_Number:
1053-73-2

# InChI:
InChI=1/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/t4-,6-,7-,10-/m1/s1

# Synthesis_Reference:
Bulletin of the Chemical Society of Japan  (1991),  64(2),  490-7.

# Melting_Point:
Not Available

# Melting_Point_predicted:
177.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
614.5 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
3.33 mg/mL [Predicted by ALOGPS]

# phys_charge:
-4

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-1.63 [Predicted by ALOGPS]; -4.7 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Adenosine_3',5'-diphosphate.mol:::1132723804343114811

# SDF_File_[Text]:
tbl_chemical:::HMDB00061.sdf:::119283164493710961

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00061.pdb:::119283164841615310

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050107_P00_08_IS_2DHSQC_1734.png:::116666179979313361

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050107_P00_08_IS_2DHSQC_1734.zip:::116666179980431150

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050107_P00_08_IS_2DHSQC_1734_Assigned.png:::116666179995412675

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Adenosine 3',5'-diphosphate.gif:::1132732104187378985

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00061_peaks.txt:::1156309519390709433

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Adenosine 3',5'-diphosphate_C.gif:::1132737671467484764

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00061_peaks.txt:::1156310709836345873

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP); golgi apparatus

# Tissue_Location:
Most Tissues (liver predominantly, also found in the brain)

# deuterated:
No

# Biofluid_Location:
Blood; Cellular Cytoplasm

# Concentration_[Normal]:
Blood	0.0024	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	0.0028	uM	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Cellular_Cytoplasm	137	uM	Adult:>18_yrs_old	Both	Normal	7877593


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Bipolar Disorder

# Pathway_Names:
Androgen and estrogen metabolism;Glycosphingolipid metabolism

# Pathway_Images:
;

# KEGG_Images:
map00150;map00600

# Pathway_Graphs:
;

# Pathway_SBMLs:
;

# Metabolic_Enzyme_1_ID:
5580

# Metabolic_Enzyme_1_Name:
Protein-tyrosine sulfotransferase 1

# Metabolic_Enzyme_1_Synonyms:
Tyrosylprotein sulfotransferase-1; TPST-1

# Metabolic_Enzyme_1_Gene_Name:
TPST1

# Metabolic_Enzyme_1_Protein_Sequence:
>Proteintyrosine sulfotransferase 1
MVGKLKQNLLLACLVISSVTVFYLGQHAMECHHRIEERSQPVKLESTRTTVRTGLDLKAN
KTFAYHKDMPLIFIGGVPRSGTTLMRAMLDAHPDIRCGEETRVIPRILALKQMWSRSSKE
KIRLDEAGVTDEVLDSAMQAFLLEIIVKHGEPAPYLCNKDPFALKSLTYLSRLFPNAKFL
LMVRDGRASVHSMISRKVTIAGFDLNSYRDCLTKWNRAIETMYNQCMEVGYKKCMLVHYE
QLVLHPERWMRTLLKFLQIPWNHSVLHHEEMIGKAGGVSLSKVERSTDQVIKPVNVGALS
KWVGKIPPDVLQDMAVIAPMLAKLGYDPYANPPNYGKPDPKIIENTRRVYKGEFQLPDFL
KEKPQTEQVE

# Metabolic_Enzyme_1_Number_of_Residues:
370

# Metabolic_Enzyme_1_Molecular_Weight:
42189

# Metabolic_Enzyme_1_Theoretical_pI:
9.49

# Metabolic_Enzyme_1_GO_Classification:
Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides

# Metabolic_Enzyme_1_Pathway:
Not Available

# Metabolic_Enzyme_1_Reaction:
3'-phosphoadenylyl sulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_1_Signals:
1-25

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.8.2.20

# Metabolic_Enzyme_1_GenBank_ID_Protein:
3046918

# Metabolic_Enzyme_1_SwissProt_ID:
TPST1_HUMAN (O60507)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
TPST1

# Metabolic_Enzyme_1_Geneatlas_id:
TPST1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:12020

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_1_Gene_Sequence:
>1113 bp
ATGGTTGGAAAGCTGAAGCAGAACTTACTATTGGCATGTCTGGTGATTAGTTCTGTGACT
GTGTTTTACCTGGGCCAGCATGCCATGGAATGCCATCACCGGATAGAGGAACGTAGCCAG
CCAGTCAAATTGGAGAGCACAAGGACCACTGTGAGAACTGGCCTGGACCTCAAAGCCAAC
AAAACCTTTGCCTATCACAAAGATATGCCTTTAATATTTATTGGRGGTGTGCCTCGGAGT
GGAACCACACTCATGAGGGCCATGCTGGACGCACATCCTGACATTCGCTGTGGAGAGGAA
ACCAGGGTCATTCCCCGAATCCTGGCCCTGAAGCAGATGTGGTCACGGTCAAGTAAAGAG
AAGATCCGCCTGGATGAGGCTGGTGTTACTGATGAAGTGCTGGATTCTGCCATGCAAGCC
TTCTTACTAGAAATTATCGTTAAGCATGGGGAGCCAGCCCCTTATTTATGTAATAAAGAT
CCTTTTGCCCTGAAATCTTTAACTTACCTTTCTAGGTTATTCCCCAATGCCAAATTTCTC
CTGATGGTCCGAGATGGCCGGGCATCAGTACATTCAATGATTTCTCGAAAAGTTACTATA
GCTGGATTTGATCTGAACAGCTATAGGGACTGTTTGACAAAGTGGAATCGTGCTATAGAG
ACCATGTATAACCAGTGTATGGAGGTTGGTTATAAAAAGTGCATGTTGGTTCACTATGAA
CAACTTGTCTTACATCCTGAACGGTGGATGAGAACACTCTTAAAGTTCCTCCAGATTCCA
TGGAACCACTCAGTATTGCACCATGAAGAGATGATTGGGAAAGCTGGGGGAGTGTCTCTG
TCAAAAGTGGAGAGATCTACAGACCAAGTAATCAAGCCAGTCAATGTAGGAGCTCTATCA
AAATGGGTTGGGAAGATACCGCCAGATGTTTTACAAGACATGGCAGTGATTGCTCCTATG
CTTGCCAAGCTTGGATATGACCCATATGCCAACCCACCTAACTACGGAAAACCTGATCCC
AAAATTATTGAAAACACTCGAAGGGTCTATAAGGGAGAATTCCAACTACCTGACTTTCTT
AAAGAAAAACCACAGACTGAGCAAGTGGAGTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF038009

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_1_Locus:
7q11.21

# Metabolic_Enzyme_1_SNPs:
rs6963646; rs6460282; rs6952182; rs6944374; rs4718329; rs1979823; rs11766473; rs3757417; rs6958531; rs17138152; rs7778911; rs4718325; rs10807703; rs7792434; rs6460280; rs17747038; rs10256544; rs6952473; rs6460281; rs12672978; rs11773634; rs6974614; rs778729; rs12534500; rs11975212; rs7787482; rs778731; rs17138149; rs778732; rs6952945; rs6964437; rs4718324; rs7783727; rs12540888; rs11764754; rs4718328; rs12670811; rs7791750; rs6977501; rs12530490; rs3757418; rs1002053; rs1547529; rs10257427; rs6956179; rs778734; rs10267430; rs7798630; rs1000464; rs1499614; rs2088653; rs7792391; rs6971509; rs11984115; rs2088655; rs778736; rs4718330; rs811880; rs4236208; rs6979636; rs7783613; rs9969301; rs7794930; rs10215948; rs6959268; rs7783889; rs2036264; rs6460293; rs10276077; rs10261398; rs6958294; rs949930; rs1499613; rs937493; rs6964530; rs6960446; rs10246941; rs4149461; rs11979489; rs6460287; rs6460290; rs778735; rs937494; rs10282433; rs7809997; rs12532675; rs7782704; rs709595; rs10224872; rs12537823; rs3936065; rs11769702; rs4718333; rs6951503; rs10950035; rs6945843; rs10255397; rs4145009; rs2173570; rs2161064; rs10447522; rs6460292; rs10228885; rs10272408; rs1363056; rs6971752; rs12531900; rs2901152; rs11760844; rs12538379; rs12538961; rs10260426; rs10247526; rs2420456; rs10257911; rs1532573; rs6460284; rs10261710; rs10950033; rs3823606; rs1392106; rs6964245; rs17138156; rs4149460; rs12532423; rs2036263; rs6958420; rs7785117; rs11768147; rs10246556; rs4623294; rs10263690; rs11770063; rs1553174; rs10807701; rs6460291; rs11767262; rs6960476; rs2901151; rs10950036; rs12530506; rs7808834; rs9969300; rs937495; rs17138154; rs10244358; rs4718331; rs2901155; rs1875057; rs4149459; rs4149467; rs7791891; rs10237568; rs12667200; rs4149463; rs4149466; rs4149458; rs10276716; rs4078376; rs4149462; rs10282107; rs12537083; rs10256705; rs10250544; rs3893216; rs709596; rs4149468; rs10259709; rs11460637; rs35504795; rs17786284; rs3735145; rs13223701; rs13235222; rs13311396; rs13243143; rs13235307; rs13241954; rs12537698; rs34202231; rs10081219; rs10551161; rs778730; rs28855425; rs13308260; rs4149457; rs35956167; rs10270729; rs13311334; rs13222781; rs34301886; rs28682868; rs36034976; rs12698515; rs6979415; rs35464623; rs13233206; rs7786735; rs10272149; rs6978365; rs13244209; rs12698514; rs13438240; rs10640642; rs3834333; rs9986696; rs11762122; rs11762748; rs34120253; rs34901501; rs35890216; rs35113195; rs13225672; rs35770115; rs13231166; rs13309940; rs9691761; rs1968224; rs34706973; rs35107589; rs34385620; rs34012021; rs13221573; rs13438239; rs34400889; rs13243986; rs7809213; rs34913718; rs36119639; rs35831914; rs34388493; rs7777221; rs34418019; rs35519372; rs34852687; rs10529729; rs1968223; rs35801073; rs34127760; rs35895773; rs9689998; rs13244329; rs10271683; rs34928553; rs12667649; rs33914866; rs35654351; rs4149465; rs34375072; rs28488978; rs13246770; rs11561738; rs11389260; rs13221700; rs7796162; rs12531677; rs7781880; rs36201433; rs35033344; rs7783779; rs35792825; rs4609085; rs11398616; rs35392168; rs1114444; rs34042568; rs2173571; rs11429562; rs11768530; rs13242367; rs1499611; rs33926447; rs1532572; rs36105944; rs13309055; rs35262053; rs34662100; rs7781937; rs11486718; rs35315242; rs13226888; rs9647880; rs13438771; rs6460285; rs35475107; rs10267559; rs35198198; rs35627732; rs13240647; rs7801332; rs35066356; rs7785250; rs35056295; rs34190132; rs35238339; rs7457838; rs35327746; rs34385213; rs4145010; rs35226613; rs35833927; rs7796424; rs10627680; rs34192300; rs13438059; rs35051150; rs34640231; rs12668269; rs36114007; rs35221632; rs4602773; rs10807702; rs34190024; rs13309920; rs4149464; rs5884584; rs10950032; rs12698516; rs4718335; rs10266831; rs9770070; rs6979452; rs13236649; rs35282216; rs5884588; rs2901153; rs1909508; rs13246714; rs3060053; rs35525840; rs12669916; rs13226038; rs4291144; rs33999559; rs35542514; rs2102042; rs34496288; rs34660335; rs34606343; rs35075387; rs10260180; rs13230545; rs9801146; rs13229020; rs6970498; rs4587224; rs34577493; rs5884585; rs35264301; rs13228421; rs13231846; rs1818045; rs34932899; rs35172112; rs34378055; rs34785172; rs34653677; rs12671152; rs4718334; rs2901079; rs1499612; rs10240949; rs3935391; rs34770175; rs35582736; rs35964655; rs36070878; rs34140755; rs2901154; rs35882416; rs13309923; rs13231220; rs3060068; rs5884586; rs34968778; rs35258981; rs13242072; rs7458282; rs13309967; rs10263593; rs34345249; rs13307016; rs1392104; rs35606730; rs778733; rs35596068; rs1532574; rs35787041; rs34918646; rs35270328; rs17138175; rs1532571; rs1565531; rs17138177; rs2279757; rs6968534; rs709597; rs7777782; rs880166

# Metabolic_Enzyme_1_General_References:
9501187

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5989

# Metabolic_Enzyme_2_Name:
Carbohydrate sulfotransferase 7

# Metabolic_Enzyme_2_Synonyms:
Chondroitin 6-sulfotransferase 2; C6ST-2; N-acetylglucosamine 6-O- sulfotransferase 1; GlcNAc6ST-4; Galactose/N-acetylglucosamine/N- acetylglucosamine 6-O-sulfotransferase 5; GST-5

# Metabolic_Enzyme_2_Gene_Name:
CHST7

# Metabolic_Enzyme_2_Protein_Sequence:
>Carbohydrate sulfotransferase 7
MKGRRRRRREYCKFALLLVLYTLVLLLVPSVLDGGRDGDKGAEHCPGLQRSLGVWSLEAA
AAGEREQGAEARAAEEGGANQSPRFPSNLSGAVGEAVSREKQHIYVHATWRTGSSFLGEL
FNQHPDVFYLYEPMWHLWQALYPGDAESLQGALRDMLRSLFRCDFSVLRLYAPPGDPAAR
APDTANLTTAALFRWRTNKVICSPPLCPGAPRARAEVGLVEDTACERSCPPVAIRALEAE
CRKYPVVVIKDVRLLDLGVLVPLLRDPGLNLKVVQLFRDPRAVHNSRLKSRQGLLRESIQ
VLRTRQRGDRFHRVLLAHGVGARPGGQSRALPAAPRADFFLTGALEVICEAWLRDLLFAR
GAPAWLRRRYLRLRYEDLVRQPRAQLRRLLRFSGLRALAALDAFALNMTRGAAYGADRPF
HLSARDAREAVHAWRERLSREQVRQVEAACAPAMRLLAYPRSGEEGDAEQPREGETPLEM
DADGAT

# Metabolic_Enzyme_2_Number_of_Residues:
486

# Metabolic_Enzyme_2_Molecular_Weight:
54267

# Metabolic_Enzyme_2_Theoretical_pI:
9.96

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the transfer of sulfate to position 6 of non- reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O- sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc

# Metabolic_Enzyme_2_Pathway:
map00532  Chondroitin / Heparan sulfate biosynthesis

# Metabolic_Enzyme_2_Reaction:
3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_2_Signals:
1-34

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.8.2.17

# Metabolic_Enzyme_2_GenBank_ID_Protein:
10336539

# Metabolic_Enzyme_2_SwissProt_ID:
CHST7_HUMAN (Q9NS84)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
CHST7

# Metabolic_Enzyme_2_Geneatlas_id:
CHST7

# Metabolic_Enzyme_2_hgnc_id:
HGNC:13817

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_2_Gene_Sequence:
>1461 bp
ATGAAGGGCCGGCGGCGGCGACGCCGAGAGTACTGCAAGTTCGCGCTGCTGTTGGTGCTG
TACACGCTGGTGCTGTTGCTCGTCCCCTCCGTATTGGACGGCGGCCGCGACGGGGACAAG
GGCGCCGAGCACTGCCCCGGCCTGCAGCGCAGCCTGGGAGTGTGGAGCCTGGAGGCGGCG
GCGGCCGGCGAACGCGAGCAGGGAGCGGAGGCGCGGGCCGCCGAGGAAGGGGGCGCGAAC
CAGTCTCCTCGGTTCCCAAGCAACCTCAGCGGCGCTGTCGGGGAGGCAGTGTCTCGCGAG
AAGCAGCACATCTACGTGCATGCCACCTGGCGCACCGGCTCGTCCTTCCTGGGCGAACTC
TTTAACCAGCACCCGGACGTTTTCTACTTGTATGAGCCCATGTGGCATCTATGGCAGGCG
CTGTATCCGGGCGACGCCGAGAGCTTGCAGGGCGCGCTGCGCGACATGCTGCGTTCGCTC
TTCCGCTGCGACTTCTCCGTGCTGCGGCTGTACGCGCCGCCGGGGGACCCCGCTGCGCGC
GCCCCGGACACGGCCAATCTTACCACGGCCGCCCTCTTCCGCTGGCGGACTAACAAGGTC
ATCTGCTCGCCGCCACTGTGTCCTGGCGCACCCCGTGCCCGGGCCGAGGTGGGCCTCGTC
GAGGACACCGCCTGCGAGCGCAGCTGCCCACCCGTGGCGATACGCGCCCTGGAGGCCGAG
TGCCGAAAGTACCCGGTGGTGGTCATCAAGGACGTGCGCCTGCTCGATCTGGGCGTGCTG
GTGCCCCTGTTGCGTGATCCAGGCCTCAACCTGAAGGTGGTGCAGCTTTTCCGCGACCCG
AGGGCGGTGCACAACTCGCGCCTCAAGTCTAGGCAGGGACTGCTGCGCGAGAGCATCCAG
GTGCTGCGCACCCGCCAGAGGGGCGACCGCTTCCACCGTGTGCTGCTGGCGCACGGCGTG
GGTGCTCGCCCCGGGGGCCAGTCTCGCGCGCTGCCCGCCGCGCCGCGCGCCGATTTCTTC
CTGACCGGTGCGCTCGAGGTGATCTGCGAAGCCTGGCTGCGCGATCTGCTTTTCGCGCGC
GGCGCGCCCGCCTGGCTGCGGCGCCGCTACCTGAGGCTGCGCTATGAGGACCTGGTGCGG
CAGCCACGCGCCCAGCTGCGCCGCCTGCTGCGCTTCTCCGGGCTACGCGCGCTCGCAGCG
CTCGATGCCTTCGCGCTCAACATGACTCGCGGCGCGGCCTACGGCGCCGACCGGCCCTTC
CACCTGTCAGCGCGCGACGCCCGGGAGGCGGTGCACGCCTGGCGCGAGCGCCTGAGCCGA
GAGCAGGTGCGCCAGGTGGAGGCCGCCTGCGCTCCAGCCATGCGTCTGCTCGCCTACCCT
CGCAGCGGAGAGGAGGGCGACGCGGAGCAGCCCAGGGAAGGGGAGACGCCGCTGGAGATG
GATGCCGACGGCGCCACGTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AB040711

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_2_Locus:
Xp11.23

# Metabolic_Enzyme_2_SNPs:
rs760697; rs735716; rs6521128; rs6609426; rs1117956; rs2072839; rs6521125; rs6521127; rs5952909; rs5906235; rs5906239; rs6521126; rs1003507; rs2006250; rs12012841; rs1987792; rs12011965; rs7056956; rs5952391; rs11796837; rs2064124; rs2179208; rs3788767; rs5906237; rs17147366; rs6611261; rs5952910; rs7065703; rs11311886; rs4989685; rs12835923; rs34374857; rs6611268; rs7055608; rs6651856; rs2205929; rs6611262; rs6611266; rs35964924; rs12845036; rs34212385; rs34705851; rs4989684; rs10538719; rs6611265; rs34177520; rs35460619; rs6611267; rs4989687; rs34318390; rs6611263; rs11369586; rs11435754; rs4989683; rs3071957; rs5952390; rs9331470; rs7877371; rs34049715; rs4989686; rs35615048; rs5906238; rs3830735; rs10590687; rs34822854; rs35291875; rs12840929; rs12013644; rs12014644; rs12688544; rs17147375; rs1883255; rs2072840; rs2076078; rs2272821; rs2272822; rs3209594; rs4824584; rs5905551; rs5906244; rs5906245; rs6521132; rs6611269; rs6640; rs732316; rs7473341; rs7888387

# Metabolic_Enzyme_2_General_References:
10781596; 10956661

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5576

# Metabolic_Enzyme_3_Name:
Heparan sulfate glucosamine 3-O-sulfotransferase 3A1

# Metabolic_Enzyme_3_Synonyms:
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1; Heparan sulfate 3-O-sulfotransferase 3A1; h3-OST-3A

# Metabolic_Enzyme_3_Gene_Name:
HS3ST3A1

# Metabolic_Enzyme_3_Protein_Sequence:
>Heparan sulfate glucosamine 3Osulfotransferase 3A1
MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGG
EEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGL
SGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRA
VGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIV
VVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLR
HFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSR
PHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG

# Metabolic_Enzyme_3_Number_of_Residues:
406

# Metabolic_Enzyme_3_Molecular_Weight:
44900

# Metabolic_Enzyme_3_Theoretical_pI:
9.98

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Transfers a sulfuryl group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate

# Metabolic_Enzyme_3_Pathway:
Not Available

# Metabolic_Enzyme_3_Reaction:
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
25-43

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.8.2.30

# Metabolic_Enzyme_3_GenBank_ID_Protein:
4835723

# Metabolic_Enzyme_3_SwissProt_ID:
OST3A_HUMAN (Q9Y663)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
HS3ST3A1

# Metabolic_Enzyme_3_Geneatlas_id:
HS3ST3A1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:5196

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Probable)

# Metabolic_Enzyme_3_Gene_Sequence:
>1221 bp
ATGGCCCCTCCGGGCCCGGCCAGTGCCCTCTCCACCTCGGCCGAGCCGCTGTCCCGCAGC
ATCTTCCGGAAGTTCTTGCTGATGCTCTGCTCCCTGCTCACGTCCCTTTACGTCTTCTAC
TGCCTGGCCGAGCGCTGCCAGACCCTGTCCGGCCCCGTCGTGGGGCTGTCCGGCGGCGGC
GAGGAGGCGGGGGCCCCTGGTGGCGGCGTCCTGGCCGGAGGCCCGAGGGAGCTGGCGGTG
TGGCCGGCGGCGGCACAGAGAAAGCGCCTCCTGCAACTGCCGCAGTGGCGGAGGCGCCGG
CCGCCCGCGCCCCGCGACGACGGCGAGGAGGCGGCCTGGGAAGAAGAGTCCCCTGGCCTG
TCAGGGGGTCCGGGCGGCTCCGGGGCCGGAAGCACCGTGGCCGAGGCCCCGCCGGGGACC
CTGGCGCTGCTCCTGGACGAAGGCAGCAAGCAGCTGCCGCAGGCCATCATCATCGGAGTG
AAGAAGGGCGGCACGCGGGCGCTGCTGGAGTTCCTGCGCGTGCACCCCGACGTGCGCGCC
GTGGGCGCCGAGCCCCACTTCTTCGACCGCAGCTACGACAAGGGCCTCGCCTGGTACCGG
GACCTGATGCCCAGAACCCTGGACGGGCAGATCACCATGGAGAAGACGCCCAGTTACTTC
GTCACGCGGGAGGCCCCCGCGCGCATCTCGGCCATGTCCAAGGACACCAAGCTCATCGTG
GTGGTGCGGGACCCGGTGACCAGGGCCATCTCGGACTACACGCAGACGCTGTCCAAGCGG
CCCGACATCCCCACCTTCGAGAGCTTGACGTTCAAAAACAGGACAGCGGGCCTCATCGAC
ACGTCGTGGAGCGCCATCCAGATCGGCATCTACGCCAAGCACCTGGAGCACTGGCTGCGC
CACTTCCCCATCCGCCAGATGCTCTTCGTGAGCGGCGAGCGGCTCATCAGCGACCCGGCC
GGGGAGCTGGGCCGCGTGCAAGACTTCCTGGGCCTCAAGAGGATCATCACGGACAAGCAC
TTCTACTTCAACAAGACCAAGGGCTTCCCCTGCCTGAAGAAGGCGGAGGGCAGCAGCCGG
CCCCATTGCCTGGGCAAGACCAAGGGCAGGACCCATCCTGAGATCGACCGCGAGGTGGTG
CGCAGGCTGCGCGAGTTCTACCGGCCTTTCAACCTCAAGTTCTACCAGATGACCGGGCAC
GACTTTGGCTGGGATGGATAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
AF105376

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_3_Locus:
17p12-p11.2

# Metabolic_Enzyme_3_SNPs:
rs2874899; rs1006483; rs1981629; rs1981630; rs2190859; rs1990237; rs3785698; rs7210104; rs6502282; rs7211449; rs8069715; rs8082242; rs1990238; rs1029680; rs6502274; rs1029681; rs7224549; rs7224624; rs9892731; rs11869035; rs9915200; rs12602763; rs3785701; rs10521227; rs6502273; rs7220457; rs3826370; rs11651136; rs11078166; rs10521230; rs9916623; rs3785692; rs10521226; rs7207411; rs7210084; rs6502281; rs7223801; rs1978218; rs8073109; rs9674441; rs2098026; rs3785702; rs2052010; rs11078168; rs4792373; rs7220749; rs3785709; rs7212673; rs7224618; rs9894020; rs9902049; rs9903707; rs11651832; rs12450600; rs7224304; rs7211903; rs8077058; rs12600939; rs8075558; rs8070022; rs7224721; rs4792371; rs9903006; rs3826371; rs12941976; rs10521223; rs2322887; rs4792370; rs12943793; rs2190854; rs12051798; rs4791552; rs12943188; rs12452587; rs8079724; rs3785696; rs12949630; rs16948136; rs8078647; rs12150034; rs9893620; rs9891162; rs7211399; rs11870587; rs9303081; rs11869547; rs3785699; rs7224244; rs12051738; rs12949477; rs11078167; rs9897001; rs3785703; rs9896557; rs11868328; rs2024088; rs8069770; rs16948066; rs3785693; rs7216579; rs7220804; rs7216732; rs11650867; rs8081884; rs4792367; rs9889522; rs11655175; rs8073867; rs11870511; rs16948063; rs11872064; rs765583; rs12600532; rs6502280; rs726800; rs9908274; rs12943958; rs10521225; rs12950398; rs8070276; rs9941385; rs8076268; rs7213348; rs1544513; rs8065036; rs8080066; rs9797140; rs9891471; rs7222005; rs8082418; rs6502278; rs16948117; rs11870856; rs7207081; rs3785690; rs3785697; rs11078164; rs726799; rs16948095; rs3785710; rs2322886; rs7209410; rs8069057; rs8080788; rs8080724; rs8076060; rs3785705; rs7217404; rs11868793; rs8082581; rs9899269; rs10521224; rs6502271; rs8074677; rs11868777; rs7503357; rs12944977; rs8075792; rs8074283; rs7219427; rs3785695; rs12949546; rs11870605; rs7212024; rs8080787; rs3826369; rs12952904; rs6502275; rs4792369; rs8066914; rs11868857; rs8067572; rs8067291; rs16948061; rs3785689; rs9906327; rs3785691; rs9913253; rs9897176; rs9899009; rs9892103; rs12936110; rs8080826; rs11871419; rs8079179; rs6502279; rs8068060; rs4588021; rs11653452; rs9789074; rs9941372; rs8065492; rs8081728; rs16948143; rs8079344; rs12232504; rs8068380; rs9889329; rs9898944; rs11652854; rs11655905; rs9889319; rs9892843; rs12601584; rs4792374; rs9904006; rs9891702; rs9908008; rs7211993; rs7211684; rs16948035; rs9892266; rs12941565; rs7224266; rs8075934; rs7211855; rs12940889; rs11078163; rs5019434; rs3785706; rs16940824; rs7221479; rs1860068; rs11658774; rs12942815; rs1963228; rs12953236; rs9941369; rs8078547; rs6502269; rs8081890; rs12452014; rs8068402; rs6502270; rs6502276; rs1963229; rs11868901; rs8080565; rs4399565; rs12949669; rs2052009; rs9907736; rs9916774; rs7211531; rs1029682; rs9912697; rs9909684; rs7218451; rs8078902; rs1029678; rs11872035; rs4792368; rs6502277; rs11869531; rs12952215; rs9898640; rs9898644; rs4792372; rs12051902; rs7218779; rs11078162; rs7218968; rs8078704; rs6502268; rs11650199; rs8080913; rs7213783; rs4792364; rs1005639; rs9909849; rs16948010; rs6502283; rs9901347; rs12450266; rs16940819; rs17661499; rs17661391; rs16940820; rs16948007; rs1047933; rs11385090; rs9891434; rs36029843; rs11450860; rs10542966; rs34464995; rs11422560; rs10631691; rs35647775; rs10708633; rs7218021; rs34162332; rs7223591; rs34400575; rs35996200; rs11284743; rs34480904; rs8075694; rs5819417; rs35663599; rs3837822; rs12051577; rs10712577; rs28538092; rs10574301; rs34727614; rs7216066; rs9891322; rs12232510; rs35910743; rs12950206; rs34511714; rs33924561; rs8076396; rs7210249; rs34794064; rs12602215; rs34127629; rs34381743; rs35615297; rs35991739; rs35082160; rs10698827; rs34005753; rs34829401; rs34691943; rs36009056; rs12150035; rs28454210; rs35402627; rs4438344; rs12947760; rs35232315; rs10631255; rs882444; rs34383588; rs10690930; rs726801; rs34246869; rs34042466; rs7214526; rs35492363; rs726744; rs10542965; rs11353885; rs28585481; rs34187651; rs9890224; rs34129080; rs35307048; rs33946792; rs882445; rs12944368; rs3785707; rs12939398; rs4792366; rs1860069; rs12949981; rs34872160; rs34765172; rs12945849; rs3785704; rs35913870; rs28485048; rs17880140; rs34804183; rs35344325; rs36019089; rs11381440; rs34734097; rs8074445; rs9910118; rs10566240; rs12939529; rs35699435; rs10639272; rs9911028; rs34256601; rs11313103; rs34220378; rs9903786; rs10622364; rs7226261; rs8069692; rs11452558; rs34236043; rs34309018; rs35028643; rs35262885; rs4792365; rs9903267; rs35808530; rs3785700; rs11656598; rs11459083; rs35959207; rs758222; rs35531948; rs34383911; rs35402358; rs34054037; rs12949620; rs10651517; rs34062668; rs9909677; rs35125302; rs8075866; rs5819419; rs35032914; rs28514885; rs34792239; rs35867770; rs35690872; rs34149033; rs35629205; rs35514007; rs35773103; rs36095876; rs10602576; rs10643456; rs35576072; rs8069928; rs35868696; rs8076936; rs9902595; rs17663433; rs1003905; rs34925326; rs12949787; rs34346972; rs11369821; rs9899316; rs7207494; rs17663088; rs8079758; rs10633342; rs5819418; rs35603249; rs7209642; rs11395087; rs8070041; rs9900410; rs1029679; rs9892533; rs35975757; rs34331160; rs12953261; rs9913045; rs35264996; rs12940735; rs34470811; rs12951100; rs10525412; rs9896008; rs28454647; rs3785694; rs34017855; rs34995100; rs34479454; rs7225570; rs34254550; rs34231568; rs11459574; rs35865369; rs34850333; rs35667275; rs10535139; rs34016229; rs34607274; rs12948656; rs12950726; rs11271183; rs34559000; rs35527988; rs3080921; rs35611722; rs33976726; rs34767292; rs9895752; rs9891186; rs4613101; rs35056447; rs7224886; rs34006334; rs35342507; rs8068073; rs8082110; rs8075587; rs4555186; rs35713475; rs10632927; rs34645406; rs35525593; rs36039529; rs34159540; rs16948153; rs34243920; rs11314005; rs11440630; rs11424342; rs10622404; rs28651899; rs10709522; rs34845612; rs8075586; rs7210309; rs8073722; rs35674068; rs9905396; rs10672405; rs34991907; rs36095959; rs4416053; rs34578615; rs34161457; rs7209746; rs4307986; rs35898961; rs8077943; rs9907497; rs1476743; rs8064266; rs11656465; rs6146000; rs10588643; rs35133450; rs10521231; rs11078161; rs11867655; rs11870772; rs11871020; rs16947982; rs16947988; rs16947990; rs16947993; rs16947996; rs16947999; rs17663499; rs2190861; rs2215116; rs35940504; rs3744335; rs3744336; rs3744337; rs4513137; rs4792375; rs6502264; rs6502266; rs7209938; rs7213995; rs7214167; rs7216489; rs7216640; rs7216793; rs7220667; rs8070423; rs8073503; rs8073804; rs8074072; rs8075029; rs8081227; rs8081360; rs9675262; rs9889837

# Metabolic_Enzyme_3_General_References:
9988767; 12975309; 10520990; 9988768

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5588

# Metabolic_Enzyme_4_Name:
Heparan sulfate glucosamine 3-O-sulfotransferase 2

# Metabolic_Enzyme_4_Synonyms:
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2; Heparan sulfate 3-O-sulfotransferase 2; h3-OST-2

# Metabolic_Enzyme_4_Gene_Name:
HS3ST2

# Metabolic_Enzyme_4_Protein_Sequence:
>Heparan sulfate glucosamine 3Osulfotransferase 2
MAYRVLGRAGPPQPRRARRLLFAFTLSLSCTYLCYSFLCCCDDLGRSRLLGAPRCLRGPS
AGGQKLLQKSRPCDPSGPTPSEPSAPSAPAAAVPAPRLSGSNHSGSPKLGTKRLPQALIV
GVKKGGTRAVLEFIRVHPDVRALGTEPHFFDRNYGRGLDWYRSLMPRTLESQITLEKTPS
YFVTQEAPRRIFNMSRDTKLIVVVRNPVTRAISDYTQTLSKKPDIPTFEGLSFRNRTLGL
VDVSWNAIRIGMYVLHLESWLQYFPLAQIHFVSGERLITDPAGEMGRVQDFLGIKRFITD
KHFYFNKTKGFPCLKKTESSLLPRCLGKSKGRTHVQIDPEVIDQLREFYRPYNIKFYETV
GQDFRWE

# Metabolic_Enzyme_4_Number_of_Residues:
367

# Metabolic_Enzyme_4_Molecular_Weight:
41501

# Metabolic_Enzyme_4_Theoretical_pI:
10.39

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Transfers a sulfuryl group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate

# Metabolic_Enzyme_4_Pathway:
Not Available

# Metabolic_Enzyme_4_Reaction:
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_4_Signals:
1-36

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.8.2.29

# Metabolic_Enzyme_4_GenBank_ID_Protein:
4835719

# Metabolic_Enzyme_4_SwissProt_ID:
OST2_HUMAN (Q9Y278)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
HS3ST2

# Metabolic_Enzyme_4_Geneatlas_id:
HS3ST2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:5195

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Probable)

# Metabolic_Enzyme_4_Gene_Sequence:
>1104 bp
ATGGCCTATAGGGTCCTGGGCCGCGCGGGGCCACCTCAGCCGCGGAGGGCGCGCAGGCTG
CTCTTCGCCTTCACGCTCTCGCTCTCCTGCACTTACCTGTGTTACAGCTTCCTGTGCTGC
TGCGACGACCTGGGTCGGAGCCGCCTCCTCGGCGCGCCTCGCTGCCTCCGCGGCCCCAGC
GCGGGCGGCCAGAAACTTCTCCAGAAGTCCCGCCCCTGTGATCCCTCCGGGCCGACGCCC
AGCGAGCCCAGCGCTCCCAGCGCGCCCGCCGCCGCCGTGCCCGCCCCTCGCCTCTCCGGT
TCCAACCACTCCGGCTCACCCAAGCTGGGTACCAAGCGGTTGCCCCAAGCCCTCATTGTG
GGCGTGAAGAAGGGGGGCACCCGGGCCGTGCTGGAGTTTATCCGAGTACACCCGGACGTG
CGGGCCTTGGGCACGGAACCCCACTTCTTTGACAGGAACTACGGCCGCGGGCTGGATTGG
TACAGGAGCCTGATGCCCAGGACCCTCGAGAGCCAGATCACGCTGGAGAAGACGCCCAGC
TACTTTGTCACTCAAGAGGCTCCTCGACGCATCTTCAACATGTCCCGAGACACCAAGCTG
ATCGTGGTTGTGCGGAACCCTGTGACCCGTGCCATCTCTGATTACACGCAGACACTCTCC
AAGAAGCCCGACATCCCGACCTTTGAGGGCCTCTCCTTCCGCAACCGCACCCTGGGCCTG
GTGGACGTGTCGTGGAACGCCATCCGCATCGGCATGTACGTGCTGCACCTGGAGAGCTGG
CTGCAGTACTTCCCGCTAGCTCAGATTCACTTCGTCAGTGGCGAGCGACTCATCACTGAC
CCGGCCGGCGAGATGGGGCGAGTCCAGGACTTCCTGGGCATTAAGAGATTCATCACGGAC
AAGCACTTCTATTTCAACAAGACCAAAGGATTCCCTTGCTTGAAAAAAACAGAATCGAGC
CTCCTGCCTCGATGCTTGGGCAAATCAAAAGGGAGAACTCATGTACAGATTGATCCTGAA
GTGATAGACCAGCTCCGAGAATTTTATAGACCGTATAATATCAAATTTTATGAAACCGTT
GGGCAGGACTTCAGGTGGGAATAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF105374

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_4_Locus:
16p12

# Metabolic_Enzyme_4_SNPs:
rs208951; rs1054028; rs8063819; rs8063925; rs208633; rs457812; rs208960; rs208618; rs1989806; rs209456; rs2238484; rs182322; rs2239337; rs169660; rs2655110; rs2283531; rs2247521; rs169645; rs208956; rs208637; rs208569; rs1503951; rs208608; rs2002593; rs7193867; rs7195630; rs9927297; rs9302400; rs2283530; rs80946; rs2239333; rs3819564; rs11865532; rs457746; rs8064157; rs11641723; rs985252; rs1012004; rs2283537; rs208965; rs208636; rs208635; rs208630; rs209453; rs2519975; rs9930452; rs77281; rs7199670; rs7191228; rs2369690; rs176389; rs2015695; rs7186170; rs7205890; rs380059; rs378251; rs456136; rs876009; rs7198577; rs377967; rs208941; rs208617; rs4783491; rs209452; rs12597004; rs2238486; rs463131; rs208570; rs6497609; rs2256590; rs460093; rs9939816; rs2519974; rs8062655; rs11861633; rs16951783; rs463680; rs16973436; rs2283526; rs9937960; rs12102329; rs10492789; rs1827586; rs2283533; rs2239336; rs2238487; rs2519973; rs7201561; rs208964; rs208953; rs208943; rs372193; rs208634; rs16973865; rs209451; rs210090; rs208958; rs208627; rs208619; rs7192450; rs208613; rs2283524; rs2239334; rs1978073; rs208942; rs395354; rs16973698; rs16973845; rs186002; rs13336801; rs16973454; rs208607; rs2239335; rs8062028; rs13331003; rs208609; rs916670; rs456997; rs1978075; rs208628; rs209454; rs2519971; rs2655111; rs2283527; rs2283535; rs9806846; rs2550776; rs11864419; rs17780716; rs208615; rs10492788; rs12597026; rs2283532; rs460147; rs7193998; rs13332627; rs208611; rs876008; rs458544; rs876047; rs208954; rs2238480; rs2238482; rs11865465; rs11644022; rs13336188; rs390125; rs12599148; rs208612; rs373370; rs365023; rs208957; rs208938; rs4459532; rs2106365; rs2238481; rs2238483; rs9935677; rs2188329; rs8047379; rs2283523; rs2283525; rs7188335; rs16973818; rs2283528; rs16973853; rs13335054; rs17723575; rs208959; rs2238489; rs9933179; rs1827585; rs373319; rs11641851; rs3848257; rs208616; rs208952; rs12598532; rs460473; rs448189; rs208629; rs8063466; rs370740; rs12598007; rs399487; rs2238485; rs208614; rs366176; rs208610; rs17724029; rs16973811; rs16973580; rs389843; rs8064119; rs12932314; rs3845198; rs12922115; rs467164; rs13331591; rs916669; rs9922535; rs3859040; rs208631; rs9935663; rs7201204; rs8049673; rs367580; rs415722; rs208626; rs2239331; rs208949; rs2239332; rs17725080; rs35682499; rs35687470; rs5816193; rs12923372; rs10642035; rs7499364; rs208571; rs11319899; rs208963; rs10444989; rs34427041; rs34830506; rs10563205; rs28427304; rs28736805; rs9929320; rs384338; rs34239063; rs34491709; rs9928000; rs28713465; rs28416252; rs9933364; rs12931746; rs35955821; rs13330028; rs11074523; rs10643658; rs9931087; rs7499382; rs34589470; rs12918527; rs4783493; rs2283529; rs12444290; rs34411777; rs445689; rs9932966; rs10632603; rs11639723; rs35897591; rs35096568; rs34717449; rs9939734; rs9939623; rs11458203; rs35510506; rs7188185; rs35633950; rs34248118; rs8049832; rs4556774; rs35790450; rs12600173; rs376509; rs34077885; rs28548636; rs12921390; rs3073666; rs34008677; rs2519968; rs12923238; rs28636398; rs33932785; rs10651723; rs5816196; rs8063961; rs11285807; rs7195743; rs35514422; rs35509216; rs34732490; rs28375091; rs209455; rs34615305; rs35409090; rs2521808; rs208961; rs169643; rs34167039; rs10654451; rs28736594; rs35746218; rs35913118; rs9938635; rs35867719; rs11302525; rs34246011; rs7186863; rs28516623; rs3819563; rs11282599; rs5816192; rs35972666; rs34819026; rs28632053; rs13335671; rs34924385; rs28449667; rs4783492; rs2549659; rs28418420; rs35349166; rs2283534; rs34422265; rs35632830; rs462184; rs35724979; rs3831620; rs3078726; rs34122075; rs34064588; rs10622829; rs34964218; rs2519969; rs7500168; rs9935922; rs208955; rs34223434; rs35788387; rs34710184; rs12930908; rs35471983; rs34266171; rs34942780; rs5816195; rs34378233; rs12920187; rs28405914; rs5816191; rs150356; rs35769672; rs11642548; rs1875778; rs28712658; rs34808497; rs35012150; rs35203892; rs10083734; rs35210441; rs34698900; rs7196029; rs3078722; rs34887169; rs11463503; rs4783370; rs10603570; rs35197147; rs2369691; rs376849; rs34338465; rs10083817; rs12932378; rs5816194; rs150345; rs28405341; rs34083097; rs34409326; rs35443662; rs9922050; rs34567112; rs34412111; rs1978074; rs34170345; rs34902541; rs9924086; rs12597828; rs11383417; rs35525307; rs10713607; rs3216339; rs28594678; rs11647307; rs11435002; rs28481865; rs34232257; rs4505307; rs12325177; rs36018308; rs12918230; rs208632; rs41433148; rs28422815; rs451016; rs13337103; rs35978909; rs35583876; rs28515633; rs462797; rs208950; rs8053100; rs10717999; rs34648011; rs3216338; rs208948; rs34176740; rs1532780; rs34664381; rs8057256; rs34661837; rs35506706; rs34360070; rs105284; rs11074525; rs11639908; rs11641636; rs12597356; rs12599188; rs12922309; rs12925046; rs13329797; rs13331650; rs13331654; rs13331928; rs13334631; rs150342; rs150343; rs150344; rs150355; rs1503946; rs16974429; rs184080; rs1964200; rs2015762; rs2023654; rs2023655; rs2023656; rs208625; rs208944; rs208945; rs2519967; rs2655117; rs2655119; rs2655123; rs2655125; rs7190583; rs7192561; rs7200761; rs8050607; rs8050676; rs8052127; rs8052267; rs8052835; rs8053062; rs8056826; rs8058149; rs8058159; rs8058258; rs8058424; rs8058768; rs8059309; rs8059878; rs9674370; rs9921390; rs9931159

# Metabolic_Enzyme_4_General_References:
9988767; 12975309; 9988768

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5590

# Metabolic_Enzyme_5_Name:
Protein-tyrosine sulfotransferase 2

# Metabolic_Enzyme_5_Synonyms:
Tyrosylprotein sulfotransferase-2; TPST-2

# Metabolic_Enzyme_5_Gene_Name:
TPST2

# Metabolic_Enzyme_5_Protein_Sequence:
>Proteintyrosine sulfotransferase 2
MRLSVRRVLLAAGCALVLVLAVQLGQQVLECRAVLAGLRSPRGAMRPEQEELVMVGTNHV
EYRYGKAMPLIFVGGVPRSGTTLMRAMLDAHPEVRCGEETRIIPRVLAMRQAWSKSGREK
LRLDEAGVTDEVLDAAMQAFILEVIAKHGEPARVLCNKDPFTLKSSVYLSRLFPNSKFLL
MVRDGRASVHSMITRKVTIAGFDLSSYRDCLTKWNKAIEVMYAQCMEVGKEKCLPVYYEQ
LVLHPRRSLKLILDFLGIAWSDAVLHHEDLIGKPGGVSLSKIERSTDQVIKPVNLEALSK
WTGHIPGDVVRDMAQIAPMLAQLGYDPYANPPNYGNPDPFVINNTQRVLKGDYKTPANLK
GYFQVNQNSTSSHLGSS

# Metabolic_Enzyme_5_Number_of_Residues:
377

# Metabolic_Enzyme_5_Molecular_Weight:
41912

# Metabolic_Enzyme_5_Theoretical_pI:
9.42

# Metabolic_Enzyme_5_GO_Classification:
Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides

# Metabolic_Enzyme_5_Pathway:
Not Available

# Metabolic_Enzyme_5_Reaction:
3'-phosphoadenylyl sulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_5_Signals:
1-21

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.8.2.20

# Metabolic_Enzyme_5_GenBank_ID_Protein:
3108067

# Metabolic_Enzyme_5_SwissProt_ID:
TPST2_HUMAN (O60704)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
TPST2

# Metabolic_Enzyme_5_Geneatlas_id:
TPST2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:12021

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_5_Gene_Sequence:
>1134 bp
ATGCGCCTGTCGGTGCGGAGGGTGCTGCTGGCAGCCGGCTGCGCCCTGGTCCTGGTGCTG
GCGGTTCAGCTGGGACAGCAGGTGCTAGAGTGCCGGGCGGTGCTGGCGGGCCTGCGGAGC
CCCCGGGGGGCCATGCGGCCTGAGCAGGAGGAGCTGGTGATGGTGGGCACCAACCACGTG
GAATACCGCTATGGCAAGGCCATGCCGCTCATCTTCGTGGGTGGCGTGCCTCGCAGTGGC
ACCACGTTGATGCGCGCCATGCTGGACGCCCACCCCGAGGTGCGCTGCGGCGAGGAGACC
CGCATCATCCCGCGCGTGCTGGCCATGCGCCAGGCCTGGTCCAAGTCTGGCCGTGAGAAG
CTGCGGCTGGATGAGGCGGGGGTGACGGATGAGGTGCTGGACGCCGCCATGCAGGCCTTC
ATCCTGGAGGTGATTGCCAAGCACGGAGAGCCGGCCCGCGTGCTCTGCAACAAGGACCCA
TTTACGCTCAAGTCCTCGGTCTACCTGTCGCGCCTGTTCCCCAACTCCAAGTTCCTGCTG
ATGGTGCGGGACGGCCGGGCCTCCGTGCACTCCATGATCACGCGCAAAGTCACCATTGCG
GGCTTTGACCTCAGCAGCTACCGTGACTGCCTCACCAAGTGGAACAAGGCCATCGAGGTG
ATGTACGCCCAGTGCATGGAGGTAGGCAAGGAGAAGTGCTTGCCTGTGTACTACGAGCAG
CTGGTGCTGCACCCCAGGCGCTCACTCAAGCTCATCCTCGACTTCCTCGGCATCGCCTGG
AGCGACGCTGTCCTCCACCATGAAGACCTCATTGGCAAGCCCGGTGGTGTCTCCCTGTCC
AAGATCGAGCGGTCCACGGACCAGGTCATCAAGCCTGTTAACCTGGAAGCGCTCTCCAAG
TGGACTGGCCACATCCCTGGGGATGTGGTGCGGGACATGGCCCAGATCGCCCCCATGCTG
GCTCAGCTCGGCTATGACCCTTATGCAAACCCCCCCAACTATGGCAACCCTGACCCCTTC
GTCATCAACAACACACAGCGGGTCTTGAAAGGGGACTATAAAACACCAGCCAATCTGAAA
GGATATTTTCAGGTGAACCAGAACAGCACCTCCTCCCACTTAGGAAGCTCGTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AF061254

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_5_Locus:
22q12.1

# Metabolic_Enzyme_5_SNPs:
rs5761587; rs4822735; rs763089; rs2283839; rs2283838; rs2283833; rs2283815; rs4275; rs2283821; rs2032520; rs2267091; rs9608503; rs9613208; rs7285341; rs2267085; rs2283831; rs4822743; rs732933; rs6005084; rs5761588; rs11703123; rs4822740; rs2267096; rs7290312; rs9608506; rs763090; rs4822741; rs4370; rs4239924; rs9608500; rs8140108; rs763088; rs6005067; rs2283820; rs9613209; rs7285019; rs4820685; rs2267089; rs1007877; rs9613214; rs2283836; rs4822736; rs5761613; rs2267092; rs17404243; rs6005079; rs2105916; rs2283817; rs3788402; rs2283816; rs1007876; rs5761612; rs5761614; rs16986651; rs2267082; rs2283832; rs7284329; rs4822738; rs12628737; rs9608498; rs5761603; rs7285240; rs9608505; rs2267094; rs9608501; rs5761599; rs9608509; rs5761609; rs732932; rs9613212; rs4822742; rs2267095; rs3966171; rs4822737; rs4820684; rs5752349; rs7292861; rs12628057; rs2283841; rs9613219; rs3827325; rs5752345; rs6005078; rs2283818; rs16982399; rs3944178; rs5761611; rs11704770; rs12169970; rs12165959; rs12158583; rs4149484; rs9712924; rs12168293; rs4149485; rs16982346; rs2331285; rs8140831; rs3788405; rs7284288; rs3788403; rs4822739; rs12159480; rs16982327; rs8141865; rs2283842; rs16982321; rs9613196; rs9613213; rs12628433; rs9608502; rs5761602; rs2157393; rs2283840; rs3788404; rs2331286; rs5752343; rs7288210; rs16629; rs9613206; rs2032519; rs767623; rs2283837; rs2283834; rs2267090; rs9613207; rs5761600; rs12628442; rs12627858; rs2877325; rs6005077; rs7292642; rs2283835; rs2267097; rs4822744; rs11704520; rs17404166; rs2267088; rs5761590; rs9608504; rs5761606; rs7290195; rs7288604; rs9613216; rs4820689; rs16982365; rs2267098; rs13056233; rs2187862; rs5752350; rs3788406; rs16982282; rs13055271; rs7291557; rs9608508; rs9613210; rs1011312; rs2283827; rs2283822; rs5761584; rs3752523; rs2283823; rs2283825; rs5761585; rs4149478; rs4149476; rs5752341; rs16982287; rs4149472; rs8139804; rs4149479; rs16982302; rs4822733; rs7364248; rs4149482; rs2283824; rs9613199; rs11090444; rs2283828; rs7289069; rs4822731; rs4149481; rs4820686; rs8136604; rs16982293; rs6005069; rs7284682; rs7288592; rs4822734; rs17318485; rs4149477; rs4149469; rs9625045; rs2267081; rs4822732; rs8141203; rs5997100; rs7293180; rs3088103; rs5761582; rs5761583; rs1057890; rs5761581; rs9613221; rs5761579; rs12628287; rs7291795; rs17851532; rs12169509; rs3966165; rs28478561; rs4822745; rs34500927; rs34473250; rs5761591; rs9608496; rs13058001; rs8140872; rs34710156; rs35985150; rs35346324; rs5752346; rs3966172; rs34477742; rs13054340; rs11704297; rs34865016; rs13057990; rs9613218; rs8137061; rs7289850; rs5761596; rs5997104; rs8142735; rs35086762; rs12168982; rs13053217; rs6005083; rs11435024; rs35356080; rs12167427; rs6005074; rs35902665; rs5761607; rs9608507; rs9608499; rs33949296; rs16982336; rs12158903; rs6005088; rs4049305; rs5997105; rs16982407; rs5761593; rs35465034; rs9625039; rs28524574; rs9625047; rs6005080; rs8141834; rs2267099; rs13053282; rs7364146; rs28505328; rs4820687; rs2267101; rs9625040; rs5761598; rs2267093; rs34302792; rs35924730; rs6005085; rs13054033; rs5752347; rs4049303; rs13053202; rs35532085; rs8141872; rs5761597; rs9613217; rs34491728; rs16982286; rs36180663; rs9620618; rs12168475; rs35354261; rs5761594; rs6005073; rs35877859; rs28706658; rs35934720; rs5761608; rs10540036; rs36021213; rs2877326; rs9613203; rs5844708; rs2267087; rs6005086; rs1981478; rs7286741; rs3037016; rs7290884; rs34692809; rs12628169; rs34597823; rs6005076; rs35599290; rs11326248; rs6005072; rs2283830; rs5997103; rs9625048; rs28526237; rs12167889; rs9625041; rs9798687; rs28477647; rs9608497; rs13053905; rs34525635; rs2267100; rs3216406; rs34686481; rs4820688; rs6005081; rs5752348; rs34711379; rs2267086; rs6005087; rs13058006; rs5844707; rs5761610; rs11376024; rs8135122; rs5761604; rs6005075; rs9613220; rs35938139; rs9613215; rs2283819; rs9613205; rs34762973; rs5752344; rs3885529; rs9613202; rs13055291; rs3831687; rs34248371; rs12161068; rs28380317; rs7290727; rs11376699; rs4049304; rs34907018; rs6005082; rs11271871; rs35839462; rs2267084; rs28402932; rs5761592; rs34355172; rs12157455; rs12169006; rs5997101; rs35028987; rs9613197; rs4149480; rs13055860; rs2097468; rs35823916; rs28600366; rs6005068; rs8142388; rs4149473; rs34776057; rs5752342; rs34143644; rs3937400; rs13056738; rs2283826; rs12628209; rs13056526; rs34742595; rs9620616; rs41281589; rs12172485; rs9613200; rs4149470; rs8141112; rs2097469; rs4149475; rs9613198; rs35573784; rs4149471; rs1547427; rs35595330; rs3937399; rs6005071; rs5997099; rs5752340; rs4149474; rs10609074; rs7288047; rs12628350; rs9613222; rs12159584; rs5761615; rs5761580; rs34854708; rs34556147; rs6005090; rs10555044; rs11913761; rs12158884; rs12159948; rs13055771; rs13056218; rs134150; rs134157; rs3180702; rs4822746; rs5752351; rs5761574; rs5761618; rs6005064

# Metabolic_Enzyme_5_General_References:
9736702; 9733778; 11230166; 10591208

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5585

# Metabolic_Enzyme_6_Name:
Heparan sulfate glucosamine 3-O-sulfotransferase 4

# Metabolic_Enzyme_6_Synonyms:
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4; Heparan sulfate 3-O-sulfotransferase 4; h3-OST-4

# Metabolic_Enzyme_6_Gene_Name:
HS3ST4

# Metabolic_Enzyme_6_Protein_Sequence:
>Heparan sulfate glucosamine 3Osulfotransferase 4
MARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQ
FPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAA
PGTDGWGLPSGGGGARDAWLRTPLAPSEMITAQSALPEREAQESSTTDEDLAGRRAANGS
SERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDRNYEKG
LEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQ
TLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLENWLQYFPLSQILFVSGERL
IVDPAGEMAKVQDFLGLKRVVTKKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGRTHPRI
DPDVIHRLRKFYKPFNLMFYQMTGQDFQWEQEEGDK

# Metabolic_Enzyme_6_Number_of_Residues:
456

# Metabolic_Enzyme_6_Molecular_Weight:
49827

# Metabolic_Enzyme_6_Theoretical_pI:
9.46

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Metabolic_Enzyme_6_Specific_Function:
Transfers a sulfuryl group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate

# Metabolic_Enzyme_6_Pathway:
map00532  Chondroitin / Heparan sulfate biosynthesis

# Metabolic_Enzyme_6_Reaction:
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
35-59

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.8.2.23

# Metabolic_Enzyme_6_GenBank_ID_Protein:
46398191

# Metabolic_Enzyme_6_SwissProt_ID:
OST4_HUMAN (Q9Y661)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
HS3ST4

# Metabolic_Enzyme_6_Geneatlas_id:
HS3ST4

# Metabolic_Enzyme_6_hgnc_id:
HGNC:5200

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Probable)

# Metabolic_Enzyme_6_Gene_Sequence:
>1371 bp
ATGGCCCGGTGGCCCGCACCTCCTCCGCCTCCGCCTCCGCCTCCACCTCTGGCCGCGCCG
CCGCCGCCCGGCGCCTCTGCTAAGGGGCCGCCGGCGCGCAAGCTGCTTTTTATGTGCACC
TTGTCCCTGTCTGTCACCTACCTGTGCTACAGCCTCCTGGGCGGCTCGGGCTCCCTGCAA
TTCCCTCTGGCGCTGCAGGAGTCGCCGGGCGCCGCCGCCGAGCCCCCGCCGAGCCCGCCG
CCACCCTCTCTGCTGCCTACCCCCGTGCGCCTCGGCGCCCCCTCGCAGCCGCCCGCGCCG
CCGCCGCTGGACAACGCGAGCCACGGGGAGCCGCCCGAGCCCCCAGAGCAGCCAGCCGCC
CCCGGGACCGACGGCTGGGGGCTGCCGAGCGGCGGCGGAGGCGCCCGGGACGCCTGGCTC
CGGACCCCGCTGGCCCCCAGCGAGATGATCACGGCTCAGAGCGCGCTGCCGGAGAGGGAA
GCGCAGGAGTCCAGCACCACCGACGAGGATCTCGCAGGCCGGAGAGCGGCCAACGGGAGC
AGCGAGAGGGGCGGCGCCGTCAGCACCCCCGACTATGGGGAGAAGAAGCTGCCACAGGCG
CTCATCATCGGGGTCAAGAAAGGAGGGACCCGCGCGCTGCTGGAGGCGATCCGCGTGCAC
CCGGACGTGCGGGCGGTGGGCGTAGAGCCGCACTTCTTCGACAGGAACTACGAAAAGGGG
TTGGAGTGGTACAGAAATGTGATGCCCAAGACTTTGGATGGGCAAATAACCATGGAGAAG
ACTCCAAGTTACTTTGTGACAAATGAGGCTCCCAAGCGCATTCACTCCATGGCCAAGGAC
ATCAAACTGATTGTGGTGGTGAGAAACCCCGTGACCAGGGCCATCTCTGACTACACGCAG
ACACTGTCAAAGAAACCCGAGATCCCCACCTTTGAGGTGCTGGCCTTCAAAAACCGGACC
CTCGGGCTGATCGATGCTTCCTGGAGTGCCATTCGAATAGGGATCTATGCGCTGCATCTG
GAAAACTGGCTCCAGTATTTCCCCCTCTCCCAGATCCTCTTTGTCAGTGGTGAGCGACTC
ATTGTGGACCCCGCCGGGGAAATGGCCAAAGTACAGGATTTTCTAGGCCTCAAACGTGTT
GTGACTAAGAAGCATTTCTATTTCAACAAAACCAAGGGGTTCCCTTGCCTAAAGAAGCCA
GAAGACAGCAGTGCCCCGAGGTGCTTAGGCAAGAGCAAAGGTCGGACTCATCCTCGCATT
GACCCAGATGTCATCCACAGACTGAGGAAATTCTACAAACCCTTCAACTTGATGTTTTAC
CAAATGACTGGTCAAGATTTTCAGTGGGAACAGGAAGAGGGTGATAAATGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AF105378

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_6_Locus:
16p11.2

# Metabolic_Enzyme_6_SNPs:
rs9930821; rs3803711; rs8061295; rs2943333; rs2881210; rs4073229; rs4337302; rs7193213; rs4447433; rs4533289; rs3934987; rs3923855; rs4287571; rs4787768; rs12598136; rs9989408; rs4408549; rs4238931; rs6497921; rs4470150; rs7191950; rs4787811; rs4238934; rs4262951; rs4331339; rs4238921; rs11645226; rs4544246; rs7188016; rs4238925; rs4624179; rs4075434; rs4787333; rs4407062; rs9934125; rs4386141; rs8054857; rs6497925; rs8050121; rs7498789; rs4534848; rs4073722; rs11074740; rs8058064; rs7199995; rs4075109; rs4592663; rs4238938; rs4787810; rs4628979; rs4787786; rs4787792; rs8063428; rs10852292; rs7200745; rs4564573; rs4238928; rs4559915; rs11074718; rs4520838; rs4787799; rs6497883; rs4620963; rs4787777; rs3924880; rs7200438; rs6650564; rs8059820; rs3922857; rs4787747; rs7191801; rs9933692; rs7190796; rs4448943; rs4346208; rs8054490; rs8049719; rs10163260; rs4362392; rs7197707; rs4072224; rs4787812; rs4238916; rs3923425; rs7201156; rs4238930; rs7201847; rs4436783; rs11074733; rs7203172; rs6497912; rs4129575; rs4075108; rs6497901; rs2943332; rs9928833; rs8056908; rs11865493; rs4420532; rs3924428; rs4569285; rs8059143; rs9925299; rs4303490; rs6497922; rs4238941; rs4442817; rs4633724; rs3935817; rs4787797; rs4270178; rs11074722; rs4522422; rs7201576; rs4390598; rs7187704; rs4527024; rs8046752; rs6497916; rs4286111; rs4787804; rs7200234; rs7193616; rs6497910; rs4363867; rs11645232; rs4393577; rs4319768; rs4787749; rs11859446; rs4496146; rs7200939; rs9934539; rs4075046; rs7201614; rs4238935; rs4129097; rs4787349; rs4614730; rs8051001; rs4238929; rs7200813; rs4787767; rs11074736; rs6497884; rs7190703; rs4377160; rs4076875; rs7196216; rs7190143; rs4130887; rs10852291; rs9933121; rs4129576; rs4453498; rs10163281; rs4131221; rs3935368; rs4238915; rs7205880; rs4787806; rs8063351; rs3923426; rs4477709; rs6497896; rs4644866; rs4378616; rs8061067; rs7190540; rs6497911; rs4787751; rs6497885; rs12443637; rs10852294; rs8056091; rs4294821; rs6497923; rs3803713; rs4075110; rs4541081; rs4238940; rs8049916; rs3935635; rs6497924; rs8048735; rs11074739; rs4372694; rs8049356; rs3925102; rs7500724; rs7193247; rs8050110; rs8057798; rs4787813; rs7185420; rs7190163; rs7203781; rs11644086; rs6497899; rs6497915; rs4787338; rs8048553; rs4787766; rs4787803; rs4384607; rs4238918; rs7206740; rs11862834; rs6497902; rs3923967; rs8043740; rs7203450; rs8061866; rs7195333; rs10400940; rs8048370; rs4238936; rs11640970; rs4614729; rs7201562; rs11867132; rs4548875; rs11074749; rs8045557; rs4488447; rs11074715; rs4074471; rs4381608; rs7192641; rs4787760; rs7198646; rs8062193; rs7196138; rs8050791; rs4441274; rs7206220; rs7185695; rs4787348; rs8051444; rs8047773; rs3935163; rs4380060; rs4520841; rs4447434; rs6497903; rs4787805; rs8062398; rs7194561; rs9928811; rs4073721; rs7200059; rs4787794; rs4787773; rs9923017; rs4268750; rs8059646; rs3923772; rs4787793; rs3923771; rs7195643; rs4620960; rs12325287; rs7197564; rs4305024; rs11644878; rs4583240; rs6497895; rs8052790; rs8049938; rs6497900; rs4787761; rs4787814; rs4787798; rs4550453; rs7202610; rs4430743; rs8044250; rs6497898; rs5006569; rs6497928; rs4433812; rs4787802; rs11640710; rs11074735; rs7201009; rs6497904; rs4530140; rs4441276; rs4787763; rs11863655; rs9925319; rs13331549; rs8049718; rs4511540; rs16975189; rs7204831; rs12446835; rs4078111; rs9924017; rs11641565; rs11860934; rs11867006; rs11074734; rs11864847; rs7199832; rs8047368; rs7190334; rs8063601; rs8054302; rs12444165; rs7198805; rs13336538; rs16975182; rs4787744; rs13334227; rs11648676; rs4430745; rs8055955; rs11074721; rs11647484; rs11074747; rs10220933; rs11074714; rs4429299; rs11645216; rs6497894; rs7197687; rs11639952; rs12446750; rs11859501; rs8061525; rs10221104; rs3934477; rs8055371; rs4578653; rs11074709; rs7193619; rs4072585; rs7187570; rs8050673; rs8053915; rs7193007; rs12920911; rs7195236; rs7500282; rs9302440; rs11074737; rs7188668; rs11639702; rs4324132; rs7204882; rs11646441; rs11649555; rs7499039; rs7196791; rs12444571; rs9932640; rs12446601; rs4787781; rs8044051; rs4334303; rs11865965; rs7199190; rs7193807; rs4488449; rs12919433; rs12599174; rs12598414; rs4238922; rs17625895; rs11643171; rs4787807; rs4349148; rs9934703; rs7191562; rs8060902; rs12325368; rs4787745; rs9929100; rs9926017; rs11640774; rs11641503; rs4335774; rs7193732; rs7499363; rs12596791; rs4787339; rs9933890; rs4787762; rs17718107; rs12918290; rs8049952; rs8056399; rs7206668; rs8061432; rs4468628; rs4238926; rs4417553; rs17704277; rs4611465; rs4476178; rs7184092; rs12445330; rs11647172; rs4581703; rs7193424; rs4073228; rs4632132; rs4787754; rs6497893; rs4787345; rs6497926; rs11643056; rs7193529; rs8049151; rs4522425; rs4787332; rs8058388; rs9923400; rs7201509; rs11863326; rs3924881; rs11861718; rs12444880; rs8050565; rs8048345; rs4787787; rs12599099; rs9937575; rs13335530; rs11074717; rs4559914; rs9806883; rs4787340; rs12444836; rs9929120; rs6416630; rs16975221; rs9989395; rs3803712; rs12919731; rs11643971; rs9937573; rs7204294; rs7203081; rs13331813; rs11074731; rs4787746; rs9937178; rs11861610; rs9928735; rs4605167; rs4077105; rs12599932; rs11074748; rs11862119; rs12149364; rs4130888; rs7498850; rs6497909; rs2943331; rs11861469; rs11641919; rs11640828; rs4787756; rs11641302; rs7199218; rs3935612; rs12708686; rs8045192; rs7196575; rs4392075; rs4520840; rs7500314; rs4517803; rs11648449; rs12596380; rs4467079; rs12103080; rs8059067; rs11862736; rs4369667; rs4362393; rs4438310; rs4238939; rs7205464; rs2943335; rs4262950; rs4510017; rs12931909; rs11641061; rs12445387; rs4787770; rs4570850; rs11641404; rs7500219; rs4268751; rs7193971; rs12443577; rs13336363; rs6497907; rs9937695; rs11860066; rs11862584; rs7206378; rs11641372; rs17774701; rs9933947; rs7195821; rs12596324; rs13380588; rs4787755; rs6497927; rs4787791; rs8058716; rs9926540; rs11646389; rs16975184; rs11646053; rs12373053; rs7202385; rs11640571; rs12448948; rs11074746; rs2943330; rs4787343; rs7188538; rs11640837; rs9923588; rs11639572; rs9939393; rs6497920; rs11074716; rs11859071; rs9934690; rs6497918; rs11642490; rs12448631; rs6497919; rs4480808; rs12447945; rs12708687; rs7196570; rs11074750; rs11640242; rs11639505; rs7204723; rs7500522; rs4787783; rs17703961; rs12443782; rs11645246; rs11862648; rs9938946; rs7499394; rs13334582; rs11074738; rs7197876; rs12446064; rs11074751; rs12934457; rs9933280; rs10521132; rs7186055; rs11074720; rs4787347; rs7196918; rs12444905; rs7201570; rs9931071; rs7196247; rs11074719; rs12920266; rs11861027; rs4238924; rs4297682; rs4622516; rs4787752; rs4404074; rs8058031; rs12446144; rs10852293; rs11862200; rs11864209; rs6497908; rs4787790; rs13337217; rs11863561; rs11639660; rs11859695; rs12448619; rs12708685; rs11644254; rs3809678; rs7196756; rs10163416; rs4411502; rs10163432; rs11640932; rs6650558; rs7499919; rs4787801; rs11074724; rs11862772; rs9708504; rs8051402; rs4542668; rs9939424; rs8048618; rs8050340; rs10431903; rs9921274; rs9924329; rs9939950; rs7192434; rs9924880; rs4787753; rs8047240; rs9927797; rs8050078; rs8057626; rs9924811; rs2966229; rs4471684; rs9926372; rs7204660; rs4457997; rs4513103; rs7201231; rs7200604; rs9935516; rs8045538; rs8058115; rs7200279; rs4310858; rs8050510; rs7201460; rs4309399; rs7202248; rs2943325; rs8057429; rs17704330; rs8049570; rs4523929; rs12444937; rs9921388; rs9924966; rs12443773; rs9930733; rs9923153; rs7202090; rs12935691; rs11641690; rs7187323; rs4787341; rs12598943; rs9924429; rs4555160; rs10221124; rs4302038; rs11640700; rs12922520; rs4430746; rs12443619; rs4257210; rs3936170; rs9927419; rs8046700; rs4435255; rs12600247; rs7359384; rs12926546; rs4473190; rs4787750; rs9921738; rs4525492; rs13330555; rs8056435; rs16975225; rs7185758; rs9934523; rs13330115; rs8059076; rs9888823; rs3935369; rs7200206; rs12149938; rs9921985; rs11861746; rs4491506; rs9931579; rs7190202; rs12446437; rs9927095; rs11649309; rs9708668; rs34374138; rs12232423; rs6650562; rs9922911; rs13330307; rs11640666; rs8058648; rs4416016; rs4340330; rs12446212; rs8062200; rs8046735; rs7202841; rs11074744; rs4438311; rs4787774; rs8049738; rs4505326; rs11074743; rs4787337; rs8064136; rs12933030; rs13339086; rs6650563; rs8057791; rs7499831; rs9941152; rs11074756; rs13335376; rs4787796; rs11646509; rs10852295; rs8062993; rs9937919; rs4519333; rs4238919; rs4787741; rs9944337; rs4787795; rs11645361; rs13335690; rs13330092; rs7189129; rs12149575; rs4289001; rs8051109; rs9938155; rs4309396; rs12927553; rs9921506; rs4787778; rs11862735; rs11861052; rs12933515; rs9930229; rs8053304; rs4467081; rs4131891; rs12447397; rs7191259; rs16975129; rs12597921; rs8049397; rs12930938; rs4787780; rs11074726; rs11867141; rs4474687; rs4130889; rs7190786; rs8060228; rs9302437; rs11648278; rs12935081; rs12598648; rs8046962; rs8051669; rs11645482; rs9932222; rs13339557; rs9928917; rs9938587; rs9972805; rs12447027; rs11074723; rs9928355; rs4787336; rs4448942; rs12445348; rs9929839; rs9928943; rs11648594; rs4787782; rs7185596; rs17704163; rs9928739; rs9924219; rs4423428; rs11648076; rs7198898; rs17774844; rs12933738; rs9928261; rs12597718; rs8053729; rs8060775; rs12149474; rs12445018; rs4238932; rs4346209; rs8053864; rs8050730; rs7192784; rs8048797; rs11648046; rs12102793; rs11074711; rs4412975; rs9934362; rs11640076; rs13331544; rs9921851; rs16975191; rs9923849; rs8050835; rs3935634; rs9888905; rs9924408; rs17625954; rs12922082; rs6650566; rs12443851; rs4430744; rs4787779; rs12448783; rs8050319; rs4787772; rs17718150; rs11641199; rs4417556; rs11074745; rs4479230; rs9934531; rs13334917; rs8059339; rs7500772; rs11639748; rs16975134; rs4318209; rs9929194; rs9937563; rs13339544; rs4365291; rs9922960; rs34460715; rs4523930; rs4289000; rs4578651; rs12932720; rs4238923; rs4787742; rs7195629; rs9926922; rs4534847; rs4787788; rs8044052; rs8052281; rs4552028; rs4603563; rs9931367; rs12149800; rs9708653; rs12931133; rs9933771; rs7198600; rs9934622; rs7186008; rs11640995; rs3923415; rs12448365; rs9923291; rs4787765; rs9745859; rs12929258; rs7199855; rs12919795; rs7201337; rs11643155; rs8043635; rs8061608; rs8056818; rs4787776; rs4787335; rs11642861; rs4286113; rs4787740; rs12444877; rs8050249; rs4387608; rs34215460; rs9928789; rs6650565; rs9931125; rs3923968; rs4238933; rs12921387; rs3935509; rs11866082; rs11648418; rs13335180; rs7500921; rs4787800; rs9936224; rs2943334; rs4343289; rs7199448; rs8053485; rs11860015; rs9930309; rs9923775; rs12924282; rs4430747; rs11648650; rs13336668; rs7359341; rs4238937; rs9708500; rs7201879; rs7200311; rs12930392; rs4444346; rs9302439; rs12934190; rs12922808; rs9925237; rs16975223; rs4238927; rs4072742; rs4238914; rs9923580; rs7189661; rs9937095; rs4310857; rs4302039; rs11863448; rs11644286; rs7191933; rs8057365; rs8058166; rs8051104; rs2943329; rs6650561; rs12599506; rs7205687; rs4787743; rs7201424; rs6650559; rs11074710; rs9938450; rs11645972; rs4076669; rs12928178; rs8057750; rs9929044; rs4238917; rs9931229; rs1399338; rs2943336; rs11274529; rs34647560; rs9940756; rs35731328; rs9937224; rs10636737; rs35243067; rs34411026; rs9928468; rs5006673; rs6497913; rs4787808; rs12919794; rs34265859; rs13329852; rs34812964; rs35646151; rs28498170; rs34759282; rs12925407; rs35040369; rs34717576; rs35917904; rs4502220; rs5816321; rs35600700; rs6497887; rs35694693; rs4787342; rs13337221; rs9934262; rs4464085; rs35000333; rs11382105; rs9921651; rs9934581; rs28507398; rs7202736; rs9928332; rs9926967; rs35643541; rs28810216; rs7500045; rs4238913; rs28505266; rs11446961; rs35754967; rs13329863; rs8053465; rs35038475; rs34015379; rs34123567; rs4129574; rs9923696; rs10573123; rs35493802; rs28687445; rs28368461; rs8048708; rs34373538; rs35364498; rs11648464; rs34710649; rs10561371; rs28677930; rs35876859; rs35052761; rs5816341; rs4442814; rs34506713; rs7184425; rs10468239; rs4332750; rs11864746; rs34705278; rs11866004; rs11648446; rs4078473; rs35546380; rs10679569; rs34320165; rs28515524; rs12925185; rs34363960; rs28642134; rs28627495; rs35444339; rs35421168; rs35151597; rs28603084; rs13334046; rs8061312; rs6497905; rs7189364; rs35639044; rs8051368; rs8048454; rs8061045; rs28647988; rs5816325; rs35217116; rs8045903; rs11371550; rs9937587; rs7196580; rs8046915; rs34831787; rs4787346; rs9937635; rs9934497; rs9924004; rs9925296; rs34487854; rs7500930; rs12921217; rs35890678; rs12051141; rs35792960; rs28491274; rs4787764; rs11646671; rs34713423; rs12446773; rs11335757; rs12922783; rs34129711; rs7184907; rs34718402; rs9930494; rs34114544; rs4586438; rs5816335; rs28673900; rs12597969; rs34382141; rs4787769; rs12924109; rs34201390; rs35966218; rs4486894; rs7190228; rs28394145; rs13334054; rs8054988; rs8062571; rs7186824; rs11645158; rs35607760; rs34486910; rs34914457; rs8050948; rs35457123; rs11371131; rs4393576; rs9923577; rs13336282; rs36073070; rs11382075; rs28638034; rs34662480; rs3923414; rs10687956; rs4622515; rs12930128; rs35698383; rs9788855; rs34004121; rs34449867; rs13338468; rs3923856; rs4553635; rs4371161; rs13335331; rs28839919; rs5010892; rs28685626; rs11395959; rs12448903; rs10624019; rs9926594; rs9928171; rs36097243; rs4490007; rs9933443; rs9925379; rs9940432; rs34677764; rs9935154; rs35826592; rs35400292; rs5816350; rs9941078; rs4411501; rs5816340; rs9929907; rs35896337; rs10577362; rs8051103; rs4542667; rs28665319; rs35337711; rs11860652; rs36098077; rs35819969; rs28497136; rs36048639; rs4787809; rs7202280; rs4577094; rs35401695; rs35121255; rs11454037; rs4589558; rs9922269; rs11334428; rs13336720; rs10559837; rs11305983; rs11458293; rs34394504; rs12149096; rs28493587; rs35549244; rs4278753; rs35071664; rs35630568; rs34834688; rs34204524; rs9924844; rs6145792; rs5816345; rs7198272; rs34088002; rs10674263; rs5816329; rs34930424; rs34447790; rs36059969; rs35697075; rs33971867; rs9929269; rs10561370; rs35448570; rs34804220; rs13334781; rs34729954; rs11864338; rs28401533; rs34161469; rs35791707; rs36018431; rs9927900; rs12597406; rs12923379; rs9938159; rs10651006; rs9925430; rs12447955; rs34348108; rs9926969; rs34756541; rs5006669; rs9938297; rs34520186; rs34677058; rs35614307; rs35632670; rs12918853; rs12149713; rs6650557; rs35367189; rs7499920; rs11461863; rs4628978; rs34647425; rs5816353; rs34626811; rs35412531; rs7188324; rs34652617; rs11282236; rs4640186; rs35623158; rs34824754; rs4787759; rs28803780; rs10567458; rs8045338; rs34462625; rs35666966; rs34078514; rs35246974; rs9933891; rs12599716; rs9936897; rs12325041; rs12918377; rs5816337; rs12596039; rs35373654; rs5816354; rs34500241; rs35619427; rs9745673; rs35219243; rs28440915; rs7192999; rs13336659; rs5816318; rs4303492; rs34977086; rs5816328; rs11283332; rs28488987; rs34886882; rs28370986; rs10584548; rs4129388; rs8046887; rs7192321; rs35494213; rs10586864; rs34731484; rs5816331; rs34788561; rs28528830; rs12925335; rs34422059; rs5816320; rs9924945; rs34594807; rs35773959; rs12920481; rs35595697; rs5006670; rs9926750; rs35522329; rs5816346; rs28698337; rs12925406; rs12930390; rs12447284; rs34977334; rs9940383; rs4608340; rs34281220; rs12924687; rs12929676; rs34366620; rs9936180; rs12922782; rs9924781; rs13332851; rs13336401; rs12103055; rs28376655; rs12925680; rs34252803; rs11462913; rs35889761; rs34043350; rs11373118; rs34307442; rs9673164; rs35936374; rs28667972; rs35151241; rs12922671; rs7499577; rs13335541; rs35260071; rs7195709; rs9938615; rs12925973; rs28788038; rs4146355; rs36102349; rs28571934; rs9926751; rs11639722; rs5816336; rs2618; rs35889546; rs34432867; rs10578512; rs12923662; rs12924114; rs35212361; rs12929189; rs35993664; rs10573861; rs35712506; rs11385661; rs35495384; rs36032510; rs35865418; rs28538019; rs34291979; rs34590423; rs12598909; rs12930919; rs34935475; rs35414103; rs10559838; rs8182188; rs4787789; rs34575926; rs11648110; rs12443640; rs35309498; rs4261544; rs28454623; rs34087024; rs10581302; rs8051825; rs8051536; rs12927358; rs9746540; rs34709550; rs34782468; rs13334644; rs5816324; rs11642447; rs34694041; rs35384311; rs28495173; rs4267309; rs35191445; rs34807316; rs5816334; rs9939595; rs4619411; rs13334569; rs35073748; rs34413841; rs5006671; rs7206013; rs34229019; rs4787344; rs4787775; rs28546434; rs35852179; rs10574239; rs28811945; rs11074732; rs34569639; rs35745665; rs4474686; rs5816348; rs12598410; rs35885872; rs35781458; rs8051677; rs28566156; rs35073598; rs35750134; rs12918854; rs4078472; rs28508430; rs12921342; rs34506320; rs7198298; rs35203058; rs8061416; rs36096424; rs4787331; rs12444316; rs8059098; rs5816344; rs34832139; rs8049760; rs34433036; rs35946691; rs34188019; rs12919167; rs28401507; rs34375970; rs34723104; rs35265450; rs34919123; rs34940537; rs35908885; rs28498018; rs34074856; rs35798517; rs35484055; rs34194152; rs11866361; rs35750285; rs9923810; rs4787784; rs34396943; rs34509962; rs4638585; rs28607357; rs35207548; rs35445109; rs3923844; rs5816319; rs5816327; rs10586034; rs34841030; rs12928854; rs5816332; rs12935843; rs11434979; rs7205610; rs34743904; rs7190327; rs5017151; rs35458266; rs12185151; rs9302438; rs28578145; rs2619; rs12919336; rs11866032; rs35997538; rs4583241; rs28679290; rs12923252; rs12932904; rs34160046; rs35854264; rs12446348; rs34322088; rs35046022; rs4539603; rs35956355; rs13329857; rs35010820; rs7202072; rs12919868; rs9938482; rs12925062; rs4505328; rs35528765; rs28569014; rs33911347; rs12925263; rs5816351; rs35146318; rs9930302; rs12928955; rs4496147; rs34777126; rs34440593; rs35979882; rs36107208; rs7501154; rs35454800; rs34930665; rs34915120; rs35553827; rs35167556; rs16975201; rs13336945; rs34312203; rs35094743; rs8044942; rs7199877; rs8051635; rs10617848; rs28459714; rs3935611; rs28449885; rs11342321; rs35067249; rs8051865; rs28528195; rs2966230; rs34007869; rs12932283; rs8058095; rs4360942; rs34235830; rs12325058; rs12932058; rs12924508; rs11645486; rs4476177; rs35777485; rs5010891; rs34093470; rs34758595; rs35387329; rs35622983; rs8062214; rs35058114; rs34287957; rs12932418; rs34498716; rs35020718; rs4608342; rs5816338; rs11644896; rs12923383; rs35686511; rs35723688; rs7206494; rs9936447; rs34664684; rs36082877; rs9932578; rs35663203; rs34280741; rs34731332; rs12445028; rs34439093; rs7500164; rs35905925; rs5008214; rs11644412; rs5816323; rs35024093; rs9924868; rs9944339; rs28479125; rs4603561; rs5006672; rs5816343; rs35232198; rs12597947; rs11862296; rs35124099; rs33999441; rs12445063; rs34587248; rs35871905; rs35152377; rs35379477; rs11314900; rs33919467; rs9940949; rs8049002; rs4354943; rs12923033; rs9940214; rs6145791; rs5816330; rs11406744; rs35868021; rs34341032; rs7184771; rs34678404; rs4605168; rs28398029; rs9926633; rs11403274; rs5816355; rs35023126; rs5816322; rs36048669; rs5816342; rs12923276; rs34709408; rs35034089; rs8053766; rs12934140; rs10163439; rs8047046; rs10567457; rs28650439; rs11403977; rs34366972; rs34844502; rs35486369; rs35990540; rs4485375; rs5816339; rs35240896; rs8062848; rs10697406; rs28827202; rs35101473; rs4787330; rs10538798; rs11305673; rs34935731; rs7205982; rs28402291; rs8051140; rs34083307; rs35484729; rs35744482; rs11074741; rs34809299; rs5010890; rs11424859; rs6497886; rs10558331; rs4787771; rs12149565; rs35793256; rs12923528; rs8045668; rs13334571; rs34368902; rs2966231; rs34868093; rs8045984; rs34079815; rs7190312; rs12930394; rs8043895; rs34501185; rs11459104; rs9934473; rs7196137; rs4238920; rs10539615; rs34353800; rs12930469; rs35688744; rs10594813; rs12599881; rs35959155; rs34952554; rs12925488; rs8046388; rs9923935; rs10663897; rs9924850; rs35679598; rs5816347; rs34331353; rs7196010; rs34795263; rs34600859; rs34033250; rs9923540; rs4442816; rs12935842; rs28566740; rs12934064; rs35867484; rs8052547; rs9924933; rs9921253; rs4277348; rs13339514; rs28739552; rs34873522; rs34117721; rs10640234; rs7186050; rs12925226; rs12931462; rs13331608; rs34029419; rs28601826; rs28547156; rs9922923; rs12934765; rs12922710; rs35194185; rs28413129; rs5816326; rs34744867; rs12924680; rs35178157; rs11384547; rs35442005; rs34274935; rs10604303; rs34766485; rs28558857; rs4536478; rs34896763; rs9921961; rs11862777; rs9921067; rs35406631; rs35909887; rs34339195; rs12102884; rs4787334; rs34641402; rs34106714; rs34273474; rs5816352; rs35554629; rs9929093; rs28760005; rs12934892; rs34741128; rs34878441; rs9937552; rs34505838; rs8044261; rs35085535; rs11646062; rs11866894; rs12597858; rs12597877; rs12598321; rs12598463; rs12930914; rs13330415; rs1546586; rs2943337; rs2966227; rs2966228; rs35853559; rs4390596; rs7191485; rs7197749; rs7206188; rs7206695; rs8054694; rs8062587; rs9923048; rs9935233

# Metabolic_Enzyme_6_General_References:
9988767

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5582

# Metabolic_Enzyme_7_Name:
Estrogen sulfotransferase

# Metabolic_Enzyme_7_Synonyms:
Sulfotransferase, estrogen- preferring; EST-1

# Metabolic_Enzyme_7_Gene_Name:
SULT1E1

# Metabolic_Enzyme_7_Protein_Sequence:
>Estrogen sulfotransferase
MNSELDYYEKFEEVHGILMYKDFVKYWDNVEAFQARPDDLVIATYPKSGTTWVSEIVYMI
YKEGDVEKCKEDVIFNRIPFLECRKENLMNGVKQLDEMNSPRIVKTHLPPELLPASFWEK
DCKIIYLCRNAKDVAVSFYYFFLMVAGHPNPGSFPEFVEKFMQGQVPYGSWYKHVKSWWE
KGKSPRVLFLFYEDLKEDIRKEVIKLIHFLERKPSEELVDRIIHHTSFQEMKNNPSTNYT
TLPDEIMNQKLSPFMRKGITGDWKNHFTVALNEKFDKHYEQQMKESTLKFRTEI

# Metabolic_Enzyme_7_Number_of_Residues:
294

# Metabolic_Enzyme_7_Molecular_Weight:
35127

# Metabolic_Enzyme_7_Theoretical_pI:
6.61

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
May control the level of the estrogen receptor by sulfurylating free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated

# Metabolic_Enzyme_7_Pathway:
map00150  Androgen and estrogen metabolism;
 map00920  Sulfur metabolism

# Metabolic_Enzyme_7_Reaction:
3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.8.2.4

# Metabolic_Enzyme_7_GenBank_ID_Protein:
488283

# Metabolic_Enzyme_7_SwissProt_ID:
ST1E1_HUMAN (P49888)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
SULT1E1

# Metabolic_Enzyme_7_Geneatlas_id:
SULT1E1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:11377

# Metabolic_Enzyme_7_PDB_ID:
1G3M

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_7_Gene_Sequence:
>885 bp
ATGAATTCTGAACTTGACTATTATGAAAAGTTTGAAGAAGTCCATGGGATTCTAATGTAT
AAAGATTTTGTCAAATATTGGGATAATGTGGAAGCGTTCCAGGCAAGACCAGATGATCTT
GTCATTGCCACCTACCCTAAATCTGGTACAACCTGGGTTAGTGAAATTGTGTATATGATC
TATAAAGAGGGTGATGTGGAAAAGTGCAAAGAAGATGTAATTTTTAATCGAATACCTTTC
CTGGAATGCAGAAAAGAAAACCTCATGAATGGAGTAAAACAATTAGATGAGATGAATTCT
CCTAGAATTGTGAAGACTCATTTGCCACCTGAACTTCTTCCTGCCTCATTTTGGGAAAAG
GATTGTAAGATAATCTATCTTTGCCGGAATGCAAAGGATGTGGCTGTTTCCTTTTATTAT
TTCTTTCTAATGGTGGCTGGTCATCCAAATCCTGGATCCTTTCCAGAGTTTGTGGAGAAA
TTCATGCAAGGACAGGTTCCTTATGGTTCCTGGTATAAACATGTAAAATCTTGGTGGGAA
AAGGGAAAGAGTCCACGTGTACTATTTCTTTTCTACGAAGACCTGAAAGAGGATATCAGA
AAAGAGGTGATAAAATTGATACATTTCCTGGAAAGGAAGCCATCAGAGGAGCTTGTGGAC
AGGATTATACATCATACTTCGTTCCAAGAGATGAAGAACAATCCATCCACAAATTACACA
ACACTGCCAGACGAAATTATGAACCAGAAATTGTCGCCCTTCATGAGAAAGGGAATTACA
GGAGACTGGAAAAATCACTTTACAGTAGCCCTGAATGAAAAATTTGATAAACATTATGAG
CAGCAAATGAAGGAATCTACACTGAAGTTTCGAACTGAGATCTAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
U08098

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_7_Locus:
4q13.1

# Metabolic_Enzyme_7_SNPs:
rs11569705; rs11569708; rs2091597; rs3822172; rs1881668; rs1534672; rs11569706; rs3822173; rs11573744; rs4149528; rs3775770; rs3736599; rs4149530; rs3775767; rs11573750; rs3775768; rs11573742; rs4149536; rs11573746; rs11573801; rs4149527; rs11573741; rs1220704; rs3775778; rs4149532; rs4694036; rs6600802; rs11249468; rs4149535; rs1220702; rs2331821; rs11249469; rs3775779; rs3775775; rs1852802; rs4149533; rs3775774; rs11573763; rs11249465; rs4149534; rs1852801; rs3775777; rs1220703; rs1220724; rs4149531; rs11573764; rs10019305; rs11573783; rs11249466; rs11249467; rs3842002; rs3775773; rs1220716; rs11573757; rs11249470; rs3775776; rs11573766; rs11573776; rs11573768; rs11573770; rs11573791; rs11573759; rs11573765; rs7674669; rs11573792; rs11573779; rs1238574; rs11573780; rs11573786; rs11573789; rs4235086; rs11573784; rs11573769; rs11573787; rs11573793; rs11573760; rs11573777; rs11573795; rs11573767; rs11573790; rs1220715; rs11573778; rs11573758; rs1220725; rs11573734; rs11573736; rs11573738; rs11573739; rs1231464; rs11573737; rs4149525; rs4149524; rs11573733; rs17852473; rs11573800; rs11573745; rs35543098; rs11573743; rs34879420; rs11573748; rs11549299; rs11573747; rs11573751; rs11573796; rs11573794; rs34062984; rs34196771; rs11573788; rs11573772; rs3775771; rs11573797; rs17147782; rs11573782; rs28782803; rs11464421; rs35088812; rs34026004; rs11573775; rs11573755; rs34559810; rs13113890; rs35832077; rs34678375; rs11573756; rs35965531; rs11573798; rs3077575; rs11573771; rs11573785; rs2055533; rs34408656; rs13113889; rs17147780; rs10535870; rs34468028; rs34033191; rs11573761; rs11573774; rs11573799; rs11573781; rs11573762; rs34924616; rs11573773; rs35426695; rs3822174; rs3775772; rs28489656; rs11573740; rs28727889; rs4149526; rs11573735; rs10213450; rs10213454; rs11249464; rs11569707; rs11569709; rs11569711; rs11569712; rs11569713; rs11569714; rs1220726; rs1237749; rs12499679; rs13102618; rs13115660; rs1354362; rs1503726; rs1503727; rs1529039; rs1529040; rs1590128; rs17147766; rs17147770; rs17684166; rs1827565; rs1910465; rs34139453; rs34547148; rs35942703; rs4149529; rs4334813; rs4616827; rs6600803; rs6818146; rs6845469; rs7655478

# Metabolic_Enzyme_7_General_References:
8185618; 8530066; 7779757; 10541560

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5990

# Metabolic_Enzyme_8_Name:
Heparan sulfate glucosamine 3-O-sulfotransferase 6

# Metabolic_Enzyme_8_Synonyms:
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6; Heparan sulfate 3-O-sulfotransferase 6; h3-OST-6

# Metabolic_Enzyme_8_Gene_Name:
HS3ST6

# Metabolic_Enzyme_8_Protein_Sequence:
>Heparan sulfate glucosamine 3Osulfotransferase 6
MAGSGGLGGGAGGGQGAGAGQGAALRASRAPMLLVALVLGAYCLCALPGRCPPAARAPAP
APAPSEPSSSVHRPGAPGLPLASGPGRRRFPQALIVGVKKGGTRALLEFLRLHPDVRALG
SEPHFFDRCYERGLAWYRSLMPRTLDGQITMEKTPSYFVTREAPRRIHAMSPDTKLIVVV
RNPVTRAISDYAQTLSKTPGLPSFRALAFRHGLGPVDTAWSAVRIGLYAQHLDHWLRYFP
LSHFLFVSGERLVSDPAGEVGRVQDFLGLKRVVTDKHFYFNATKGFPCLKKAQGGSRPRC
LGKSKGRPHPRVPQALVRRLQEFYRPFNRRFYQMTGQDFGWG

# Metabolic_Enzyme_8_Number_of_Residues:
342

# Metabolic_Enzyme_8_Molecular_Weight:
37187

# Metabolic_Enzyme_8_Theoretical_pI:
11.33

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
Transfers a sulfuryl group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate

# Metabolic_Enzyme_8_Pathway:
map00532  Chondroitin / Heparan sulfate biosynthesis

# Metabolic_Enzyme_8_Reaction:
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_8_Signals:
1-40

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.8.2.23

# Metabolic_Enzyme_8_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_8_SwissProt_ID:
OST6_HUMAN (Q96QI5)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
HS3ST6

# Metabolic_Enzyme_8_Geneatlas_id:
HS3ST6

# Metabolic_Enzyme_8_hgnc_id:
HGNC:14178

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Probable)

# Metabolic_Enzyme_8_Gene_Sequence:
Not Available

# Metabolic_Enzyme_8_GenBank_ID_Gene:
AE006640

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_8_Locus:
16p13.3

# Metabolic_Enzyme_8_SNPs:
rs8055325; rs337285; rs1742399; rs3751827; rs1657140; rs2974863; rs758190; rs337286; rs1657145; rs8043844; rs1657143; rs8043690; rs8064135; rs1657141; rs8046208; rs8059871; rs337287; rs911393; rs12599786; rs1657142; rs1657144; rs1742400; rs7203361; rs2982439; rs2982440; rs7201933; rs1657146; rs337288; rs35093198; rs1657147; rs740466; rs1742398; rs2982435; rs2982434; rs7197113; rs1657139; rs2982437; rs2982436; rs2429186; rs11647980; rs3751824; rs34650400; rs35593159; rs10688730; rs34887932; rs34284757; rs34979867; rs28680187; rs35777643; rs2575367; rs28520265; rs34353730; rs28516083; rs35592870; rs35715287; rs2429188; rs28537546; rs35031350; rs12445209; rs13336127; rs8045806; rs2429187; rs28463320; rs9926874; rs2859531; rs34615559; rs12599644; rs1614496; rs1626051; rs1657134; rs1657137; rs1657138; rs170894; rs173163; rs1742396; rs1742397; rs1742402; rs1742403; rs1742407; rs1742472; rs1742473; rs186940; rs2906901; rs2906902; rs2906912; rs2974862; rs2982431; rs2982432; rs2982433; rs2982445; rs337284; rs344363; rs344364; rs344365; rs344368; rs344369; rs34768642; rs7202935; rs8051883; rs8055117; rs9934128

# Metabolic_Enzyme_8_General_References:
11157797

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5584

# Metabolic_Enzyme_9_Name:
Carbohydrate sulfotransferase 1

# Metabolic_Enzyme_9_Synonyms:
Keratan sulfate Gal-6 sulfotransferase; KSST; KSGal6ST; KS6ST; Galactose/N- acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1; GST-1

# Metabolic_Enzyme_9_Gene_Name:
CHST1

# Metabolic_Enzyme_9_Protein_Sequence:
>Carbohydrate sulfotransferase 1
MQCSWKAVLLLALASIAIQYTAIRTFTAKSFHTCPGLAEAGLAERLCEESPTFAYNLSRK
THILILATTRSGSSFVGQLFNQHLDVFYLFEPLYHVQNTLIPRFTQGKSPADRRVMLGAS
RDLLRSLYDCDLYFLENYIKPPPVNHTTDRIFRRGASRVLCSRPVCDPPGPADLVLEEGD
CVRKCGLLNLTVAAEACRERSHVAIKTVRVPEVNDLRALVEDPRLNLKVIQLVRDPRGIL
ASRSETFRDTYRLWRLWYGTGRKPYNLDVTQLTTVCEDFSNSVSTGLMRPPWLKGKYMLV
RYEDLARNPMKKTEEIYGFLGIPLDSHVARWIQNNTRGDPTLGKHKYGTVRNSAATAEKW
RFRLSYDIVAFAQNACQQVLAQLGYKIAASEEELKNPSVSLVEERDFRPFS

# Metabolic_Enzyme_9_Number_of_Residues:
411

# Metabolic_Enzyme_9_Molecular_Weight:
46715

# Metabolic_Enzyme_9_Theoretical_pI:
9.18

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
Catalyzes the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation

# Metabolic_Enzyme_9_Pathway:
Not Available

# Metabolic_Enzyme_9_Reaction:
3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_9_Signals:
1-21

# Metabolic_Enzyme_9_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.8.2.21

# Metabolic_Enzyme_9_GenBank_ID_Protein:
2887403

# Metabolic_Enzyme_9_SwissProt_ID:
CHST1_HUMAN (O43916)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
CHST1

# Metabolic_Enzyme_9_Geneatlas_id:
CHST1

# Metabolic_Enzyme_9_hgnc_id:
HGNC:1969

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_9_Gene_Sequence:
>1236 bp
ATGCAATGTTCCTGGAAGGCCGTCCTCCTCCTTGCCCTGGCCTCCATTGCCATCCAGTAC
ACGGCCATCCGCACCTTCACCGCCAAGTCCTTTCACACCTGCCCCGGGCTGGCAGAGGCC
GGGCTGGCCGAGCGACTGTGCGAGGAGAGCCCCACCTTCGCCTACAACCTCTCCCGCAAG
ACCCACATCCTCATCCTGGCCACCACGCGCAGCGGCTCCTCCTTCGTGGGCCAGCTCTTC
AACCAGCACCTGGACGTCTTCTACCTGTTTGAGCCCCTCTACCACGTCCAGAACACGCTC
ATCCCCCGCTTCACCCAGGGCAAGAGCCCGGCCGACCGGCGGGTCATGCTAGGCGCCAGC
CGCGACCTCCTGCGGAGCCTCTACGACTGCGACCTCTACTTCCTGGAGAACTACATCAAG
CCGCCGCCGGTCAACCACACCACCGACAGGATCTTCCGCCGCGGGGCCAGCCGGGTCCTC
TGCTCCCGGCCTGTGTGCGACCCTCCGGGGCCAGCCGACCTGGTCCTGGAGGAGGGGGAC
TGTGTGCGCAAGTGCGGGCTACTCAACCTGACCGTGGCGGCCGAGGCGTGCCGCGAGCGC
AGCCACGTGGCCATCAAGACGGTGCGCGTGCCCGAGGTGAACGACCTGCGCGCCCTGGTG
GAAGACCCGCGATTAAACCTCAAGGTCATCCAGCTGGTCCGAGACCCCCGCGGCATTCTG
GCTTCGCGCAGCGAGACCTTCCGCGACACGTACCGGCTCTGGCGGCTCTGGTACGGCACC
GGGAGGAAACCCTACAACCTGGACGTGACGCAGCTGACCACGGTGTGCGAGGACTTCTCC
AACTCCGTGTCCACCGGCCTCATGCGGCCCCCGTGGCTCAAGGGCAAGTACATGTTGGTG
CGCTACGAGGACCTGGCTCGGAACCCTATGAAGAAGACCGAGGAGATCTACGGGTTCCTG
GGCATCCCGCTGGACAGCCACGTGGCCCGCTGGATCCAGAACAACACGCGGGGCGACCCC
ACCCTGGGCAAGCACAAATACGGCACCGTGCGAAACTCGGCGGCCACGGCCGAGAAGTGG
CGCTTCCGCCTCTCCTACGACATCGTGGCCTTTGCCCAGAACGCCTGCCAGCAGGTGCTG
GCCCAGCTGGGCTACAAGATCGCCGCCTCGGAGGAGGAGCTGAAGAACCCCTCGGTCAGC
CTGGTGGAGGAGCGGGACTTCCGCCCCTTCTCGTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AB003791

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_9_Locus:
11p11.2-p11.1

# Metabolic_Enzyme_9_SNPs:
rs3802762; rs2277272; rs1026078; rs4148899; rs4148903; rs4148895; rs4148898; rs895733; rs10742762; rs4148902; rs4148897; rs895730; rs895729; rs11603055; rs7121818; rs11826638; rs4391786; rs7105647; rs4148893; rs2012019; rs4148901; rs7121696; rs7121848; rs2028984; rs4148894; rs1447573; rs895734; rs11038605; rs4756011; rs12273164; rs41372752; rs41408648; rs41474450; rs41496154; rs41422447; rs4148904; rs3740702; rs4756010; rs7115779; rs10734535; rs12284022; rs12802857; rs4148900; rs1447570; rs12364479; rs1447574; rs12803232; rs35254532; rs895732; rs11038607; rs16938335; rs12284068; rs11549306; rs11291483; rs35088903; rs34121299; rs35459807; rs35563661; rs7104214; rs12799566; rs1447572; rs35032962; rs35099118; rs895731; rs34469228; rs35143517; rs4148896; rs1447571; rs10679625; rs4148905; rs11038606; rs35204204; rs11038604; rs35698128; rs10742763; rs10769157; rs10769158; rs10769161; rs10769162; rs10838501; rs10838503; rs11038598; rs11038599; rs11038600; rs11038601; rs11038603; rs11038608; rs11038611; rs11827784; rs12420703; rs1348963; rs1348964; rs1348965; rs1447569; rs1562460; rs1992849; rs2028985; rs34264431; rs36106594; rs4237656; rs4540819; rs4755331; rs4755334; rs4756007; rs4756008; rs4756013; rs4756014; rs6485637; rs7116428; rs7129157; rs737244; rs750397; rs750398; rs895718; rs9787901

# Metabolic_Enzyme_9_General_References:
9405439; 9639683; 10049591; 10642612; 10330415; 11310842

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5554

# Metabolic_Enzyme_10_Name:
Galactosylceramide sulfotransferase

# Metabolic_Enzyme_10_Synonyms:
GalCer sulfotransferase; Cerebroside sulfotransferase; 3'- phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase; 3'- phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase

# Metabolic_Enzyme_10_Gene_Name:
GAL3ST1

# Metabolic_Enzyme_10_Protein_Sequence:
>Galactosylceramide sulfotransferase
MLPPQKKPWESMAKGLVLGALFTSFLLLVYSYAVPPLHAGLASTTPEAAASCSPPALEPE
AVIRANGSAGECQPRRNIVFLKTHKTASSTLLNILFRFGQKHRLKFAFPNGRNDFDYPTF
FARSLVQDYRPGACFNIICNHMRFHYDEVRGLVPTNAIFITVLRDPARLFESSFHYFGPV
VPLTWKLSAGDKLTEFLQDPDRYYDPNGFNAHYLRNLLFFDLGYDNSLDPSSPQVQEHIL
EVERRFHLVLLQEYFDESLVLLKDLLCWELEDVLYFKLNARRDSPVPRLSGELYGRATAW
NMLDSHLYRHFNASFWRKVEAFGRERMAREVAALRHANERMRTICIDGGHAVDAAAIQDE
AMQPWQPLGTKSILGYNLKKSIGQRHAQLCRRMLTPEIQYLMDLGANLWVTKLWKFIRDF
LRW

# Metabolic_Enzyme_10_Number_of_Residues:
423

# Metabolic_Enzyme_10_Molecular_Weight:
48765

# Metabolic_Enzyme_10_Theoretical_pI:
8.78

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
Function:  galactose 3-O-sulfotransferase activity
Function:  galactosylceramide sulfotransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  Golgi apparatus

# Metabolic_Enzyme_10_General_Function:
Not Available

# Metabolic_Enzyme_10_Specific_Function:
Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the nonreducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro)

# Metabolic_Enzyme_10_Pathway:
map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_10_Reaction:
3'-phosphoadenylyl sulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + galactosylceramidesulfate

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF06990:Gal-3-0_sulfotr

# Metabolic_Enzyme_10_Signals:
1-33

# Metabolic_Enzyme_10_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.8.2.11

# Metabolic_Enzyme_10_GenBank_ID_Protein:
1871141

# Metabolic_Enzyme_10_SwissProt_ID:
G3ST1_HUMAN (Q99999)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
GAL3ST1

# Metabolic_Enzyme_10_Geneatlas_id:
GAL3ST1

# Metabolic_Enzyme_10_hgnc_id:
HGNC:24240

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_10_Gene_Sequence:
>1272 bp
ATGCTGCCACCGCAGAAGAAGCCCTGGGAGTCCATGGCTAAGGGGCTGGTGCTGGGCGCG
CTCTTCACTAGTTTCCTGCTGCTGGTGTACTCCTATGCCGTGCCCCCGCTGCATGCCGGC
CTGGCCTCCACGACCCCGGAGGCCGCAGCGTCCTGCTCTCCACCTGCACTCGAGCCAGAG
GCAGTGATCCGGGCCAACGGCTCGGCGGGGGAGTGCCAGCCGCGGCGCAACATCGTGTTC
TTGAAGACGCACAAGACGGCCAGCAGCACCCTGCTCAACATCCTGTTCCGCTTCGGCCAG
AAGCACCGGCTCAAGTTCGCCTTCCCTAACGGCCGCAATGACTTCGACTACCCGACCTTC
TTCGCCCGCAGCCTGGTGCAGGACTATCGGCCCGGGGCCTGCTTCAACATCATCTGCAAC
CACATGCGCTTCCACTACGACGAGGTGCGCGGCCTGGTGCCGACCAACGCCATCTTCATC
ACGGTGCTCCGCGACCCCGCCCGCTTGTTCGAGTCCTCCTTCCACTACTTCGGGCCGGTG
GTGCCCCTCACGTGGAAGCTCTCGGCCGGCGACAAGCTGACCGAGTTCCTGCAAGACCCG
GATCGCTACTACGACCCCAACGGCTTCAATGCCCACTACCTCCGAAACCTGCTCTTCTTC
GACCTGGGCTATGACAACAGCCTGGACCCCAGCAGCCCGCAGGTGCAGGAGCACATCCTG
GAGGTGGAGCGTCGCTTCCACCTGGTGCTCCTTCAAGAGTACTTCGACGAGTCGCTGGTG
CTGCTGAAGGACCTGCTGTGCTGGGAGCTGGAGGACGTGCTCTACTTCAAGCTCAACGCC
CGCCGCGACTCGCCCGTGCCGCGGCTCTCGGGGGAGCTGTATGGGCGCGCCACCGCCTGG
AACATGCTGGACTCCCACCTCTACCGCCACTTCAACGCCAGCTTCTGGCGCAAGGTGGAG
GCCTTCGGGCGGGAGCGCATGGCCCGCGAGGTGGCCGCCCTGCGCCATGCCAACGAGCGC
ATGCGGACCATCTGCATCGACGGGGGCCACGCCGTGGACGCCGCCGCCATCCAGGACGAG
GCCATGCAGCCCTGGCAGCCGCTGGGCACCAAGTCCATCCTGGGCTACAACCTCAAGAAG
AGCATCGGGCAGCGGCACGCGCAGCTCTGCCGGCGCATGCTCACGCCCGAGATCCAGTAC
CTGATGGACCTCGGCGCCAACCTGTGGGTCACCAAGCTCTGGAAGTTCATTCGCGATTTC
CTGCGGTGGTGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
D88667

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_10_Locus:
22q12.2

# Metabolic_Enzyme_10_SNPs:
rs2267161; rs5994320; rs4149488; rs4149490; rs12627772; rs42931; rs5994319; rs11912600; rs42929; rs16988782; rs5994321; rs42930; rs5749128; rs4149491; rs42928; rs2267159; rs42934; rs8142452; rs42932; rs42935; rs6518702; rs4820867; rs11704774; rs42933; rs2267158; rs4149486; rs4149493; rs42927; rs12628608; rs35336481; rs5749126; rs1015468; rs7286285; rs35997653; rs35424902; rs2528451; rs7287502; rs35703060; rs4149487; rs2528453; rs9606753; rs11307372; rs35696153; rs28700236; rs4149489; rs2412992; rs34728518; rs5844912; rs1015467; rs5844911; rs12159375; rs35211752; rs2528461; rs28838736; rs2528462; rs35908001; rs2528452; rs9606754; rs10711898; rs28636681; rs42926; rs34136895; rs9608988; rs2267160; rs12172153; rs11705676; rs9606752; rs35589021; rs1011897; rs35029608; rs2859472; rs35533918; rs5997684; rs13057430; rs9608981; rs35670229; rs35962480; rs16988790; rs2517987; rs2517991; rs2517993; rs2528454; rs2528457; rs2528458; rs2528459; rs2528460; rs42938; rs42939; rs5749124; rs5997681; rs956257; rs9621019

# Metabolic_Enzyme_10_General_References:
9030544; 10785389; 8830034

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5347

# Metabolic_Enzyme_11_Name:
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

# Metabolic_Enzyme_11_Synonyms:
Glucosaminyl N-deacetylase/N-sulfotransferase 1; NDST- 1; [Heparan sulfate]-glucosamine N-sulfotransferase 1; HSNST 1; N- heparan sulfate sulfotransferase 1; N-HSST 1[Includes: Heparan sulfate N-deacetylase 1

# Metabolic_Enzyme_11_Gene_Name:
NDST1

# Metabolic_Enzyme_11_Protein_Sequence:
>Bifunctional heparan sulfate Ndeacetylase/Nsulfotransferase 1
MPALACLRRLCRHVSPQAVLFLLFIFCLFSVFISAYYLYGWKRGLEPSADAPEPDCGDPP
PVAPSRLLPLKPVQAATPSRTDPLVLVFVESLYSQLGQEVVAILESSRFKYRTEIAPGKG
DMPTLTDKGRGRFALIIYENILKYVNLDAWNRELLDKYCVAYGVGIIGFFKANENSLLSA
QLKGFPLFLHSNLGLKDCSINPKSPLLYVTRPSEVEKGVLPGEDWTVFQSNHSTYEPVLL
AKTRSSESIPHLGADAGLHAALHATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFVDAVAF
LTGKRLSLPLDRYILVDIDDIFVGKEGTRMKVEDVKALFDTQNELRAHIPNFTFNLGYSG
KFFHTGTNAEDAGDDLLLSYVKEFWWFPHMWSHMQPHLFHNQSVLAEQMALNKKFAVEHG
IPTDMGYAVAPHHSGVYPVHVQLYEAWKQVWSIRVTSTEEYPHLKPARYRRGFIHNGIMV
LPRQTCGLFTHTIFYNEYPGGSSELDKIINGGELFLTVLLNPISIFMTHLSNYGNDRLGL
YTFKHLVRFLHSWTNLRLQTLPPVQLAQKYFQIFSEEKDPLWQDPCEDKRHKDIWSKEKT
CDRFPKLLIIGPQKTGTTALYLFLGMHPDLSSNYPSSETFEEIQFFNGHNYHKGIDWYME
FFPIPSNTTSDFYFEKSANYFDSEVAPRRAAALLPKAKVLTILINPADRAYSWYQHQRAH
DDPVALKYTFHEVITAGSDASSKLRALQNRCLVPGWYATHIERWLSAYHANQILVLDGKL
LRTEPAKVMDMVQKFLGVTNTIDYHKTLAFDPKKGFWCQLLEGGKTKCLGKSKGRKYPEM
DLDSRAFLKDYYRDHNIELSKLLYKMGQTLPTWLREDLQNTR

# Metabolic_Enzyme_11_Number_of_Residues:
882

# Metabolic_Enzyme_11_Molecular_Weight:
100869

# Metabolic_Enzyme_11_Theoretical_pI:
8.07

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Not Available

# Metabolic_Enzyme_11_Specific_Function:
Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L- selectin ligands, thereby playing a role in inflammatory response

# Metabolic_Enzyme_11_Pathway:
Not Available

# Metabolic_Enzyme_11_Reaction:
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_11_Signals:
1-35

# Metabolic_Enzyme_11_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.8.2.8

# Metabolic_Enzyme_11_GenBank_ID_Protein:
976372

# Metabolic_Enzyme_11_SwissProt_ID:
NDST1_HUMAN (P52848)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
NDST1

# Metabolic_Enzyme_11_Geneatlas_id:
NDST1

# Metabolic_Enzyme_11_hgnc_id:
HGNC:7680

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_11_Gene_Sequence:
>2649 bp
ATGCCTGCCCTGGCATGCCTCCGGAGGCTGTGTCGGCACGTGTCCCCGCAGGCTGTCCTT
TTCCTGCTGTTCATCTTCTGCCTGTTCAGCGTTTTCATCTCGGCCTACTACCTATATGGC
TGGAAGCGAGGCCTGGAGCCCTCGGCGGATGCCCCCGAGCCTGACTGCGGGGACCCGCCG
CCTGTGGCCCCCAGTCGCCTGCTGCCACTCAAGCCTGTGCAGGCAGCCACCCCTTCCCGC
ACAGACCCGTTGGTGCTGGTCTTTGTGGAGAGCCTCTACTCGCAACTGGGCCAGGAGGTG
GTGGCCATCCTGGAGTCCAGCCGCTTCAAATACCGCACAGAGATTGCGCCGGGCAAGGGT
GACATGCCCACGCTCACTGACAAGGGCCGTGGCCGCTTCGCCCTCATCATCTATGAGAAC
ATCCTCAAGTATGTCAACCTGGACGCCTGGAACCGGGAGCTGCTGGACAAGTACTGTGTG
GCCTACGGCGTGGGCATCATTGGCTTCTTCAAGGCCAATGAGAACAGCCTGCTGAGTGCG
CAGCTCAAGGGCTTCCCCCTGTTCCTGCACTCAAACCTGGGCCTGAAGGACTGCAGCATC
AACCCCAAGTCCCCGCTGCTCTACGTGACGCGACCTAGCGAGGTGGAGAAAGGTGTGCTC
CCCGGCGAGGACTGGACGGTTTTCCAGTCAAATCACTCCACCTATGAGCCAGTGCTGCTG
GCCAAGACGCGCTCGTCTGAGTCCATCCCACACCTGGGCGCAGACGCCGGCCTGCATGCT
GCACTGCACGCCACTGTGGTCCAGGACCTGGGCCTGCACGACGGCATCCAGCGCGTGCTG
TTTGGCAACAACCTGAACTTCTGGCTGCACAAGCTTGTCTTCGTGGATGCCGTGGCCTTC
CTCACGGGGAAGCGCCTCTCCCTGCCATTGGACCGCTACATCCTGGTGGACATTGATGAC
ATCTTCGTGGGCAAGGAGGGCACACGCATGAAGGTGGAGGACGTGAAGGCCCTGTTTGAC
ACACAGAACGAACTACGCGCACACATCCCAAACTTCACCTTCAACCTGGGCTACTCAGGG
AAATTCTTCCACACAGGTACCAATGCTGAGGACGCTGGGGATGATCTGCTGCTGTCGTAT
GTGAAGGAGTTCTGGTGGTTCCCCCACATGTGGAGCCACATGCAGCCCCACCTTTTCCAC
AACCAGTCCGTGTTGGCCGAGCAGATGGCCTTGAACAAGAAGTTCGCTGTCGAGCATGGC
ATTCCCACAGACATGGGGTATGCAGTGGCGCCCCACCACTCGGGCGTGTACCCCGTGCAC
GTGCAGCTGTACGAGGCTTGGAAGCAGGTGTGGAGCATCCGCGTGACCAGCACGGAGGAG
TACCCCCACCTGAAGCCAGCCCGCTACCGCCGTGGCTTCATCCACAATGGCATCATGGTT
CTCCCACGGCAGACCTGCGGCCTCTTCACACACACCATCTTCTACAACGAGTACCCTGGC
GGCTCCAGTGAGCTGGACAAAATCATCAACGGGGGCGAGCTCTTCCTCACCGTGCTCCTC
AATCCTATCAGCATCTTCATGACGCACCTGTCCAACTATGGGAATGACCGCCTGGGCCTG
TACACCTTCAAGCACCTGGTGCGCTTCCTGCACTCCTGGACGAACCTCCGGCTGCAGACA
CTGCCCCCTGTGCAGTTGGCGCAGAAGTACTTCCAGATCTTCTCCGAGGAGAAGGACCCG
CTCTGGCAGGACCCCTGCGAGGACAAACGTCACAAAGACATCTGGTCCAAGGAGAAGACG
TGTGACCGCTTCCCAAAGCTCCTCATCATCGGCCCCCAGAAAACAGGCACCACTGCCCTC
TACCTGTTCCTGGGCATGCACCCTGACCTAAGCAGCAACTACCCCAGCTCTGAGACCTTT
GAGGAGATCCAGTTTTTTAATGGCCACAACTATCACAAAGGCATCGACTGGTACATGGAG
TTCTTCCCCATCCCTTCCAACACCACCTCCGACTTCTACTTTGAGAAAAGCGCCAACTAC
TTTGATTCAGAAGTGGCGCCCCGGCGGGCAGCAGCCCTCTTGCCCAAAGCCAAGGTCCTG
ACCATCCTCATCAACCCCGCGGACCGGGCCTATTCCTGGTACCAGCACCAGCGAGCCCAT
GACGACCCAGTGGCCCTAAAGTACACCTTCCATGAGGTGATTACCGCCGGCTCTGACGCA
TCCTCGAAGCTGCGTGCCCTCCAGAACCGCTGCCTGGTCCCTGGCTGGTACGCCACCCAC
ATCGAGCGCTGGCTCAGTGCCTATCACGCCAACCAGATTCTGGTCTTGGATGGCAAACTG
CTTCGCACAGAACCTGCCAAAGTGATGGACATGGTGCAGAAGTTCCTTGGGGTGACCAAC
ACCATTGACTACCACAAAACCTTGGCGTTTGATCCAAAGAAAGGATTTTGGTGCCAACTG
CTTGAAGGAGGAAAAACCAAGTGTCTGGGCAAAAGCAAGGGCCGGAAATATCCCGAGATG
GACTTGGATTCCCGAGCCTTCCTGAAGGACTATTACCGGGACCACAACATCGAGCTCTCC
AAGCTGCTGTATAAGATGGGCCAGACACTTCCCACTTGGCTACGAGAGGACCTCCAGAAC
ACCAGGTAG

# Metabolic_Enzyme_11_GenBank_ID_Gene:
U18918

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_11_Locus:
5q33.1

# Metabolic_Enzyme_11_SNPs:
rs1290147; rs2273234; rs2273235; rs2273233; rs11959543; rs2273232; rs11994; rs3733935; rs11542921; rs6863809; rs2545340; rs2273229; rs2909809; rs6874540; rs6579792; rs10075355; rs1862213; rs2545341; rs6863373; rs3846709; rs3097830; rs3097829; rs3095902; rs2080861; rs2545342; rs2304063; rs3797621; rs3890105; rs888765; rs12517252; rs1833574; rs3095901; rs2748217; rs3797620; rs4958337; rs13356593; rs4958339; rs10073229; rs11746198; rs12657104; rs12516924; rs17713536; rs1017376; rs2748218; rs6893285; rs17713523; rs2545344; rs13170191; rs2273230; rs3776837; rs10066546; rs2273231; rs17111227; rs10075733; rs3095905; rs4642356; rs2545339; rs6863212; rs3095904; rs7736801; rs12514506; rs2249136; rs10051242; rs253293; rs253294; rs10057918; rs4409074; rs17856412; rs17850979; rs17856411; rs1045558; rs1045541; rs34851576; rs1045539; rs1045540; rs1045544; rs13181064; rs1045538; rs1045556; rs3733933; rs36071594; rs34013290; rs35953241; rs35461031; rs13362281; rs35373404; rs11365752; rs3822608; rs35444919; rs35709601; rs28593090; rs35391870; rs2304062; rs10054051; rs35458330; rs13176112; rs2909808; rs35071244; rs3776840; rs11366392; rs13357901; rs10677536; rs35667570; rs10558592; rs6890511; rs35747232; rs13169776; rs34548485; rs36046664; rs4958646; rs9918095; rs11749020; rs12514772; rs34937690; rs28517439; rs35405424; rs11418788; rs35235497; rs1298803; rs3776838; rs2304064; rs34150530; rs35785873; rs35906217; rs6890812; rs34345259; rs6895977; rs3776839; rs35013053; rs11948499; rs4958338; rs6884135; rs6877564; rs35317487; rs35577737; rs6876892; rs4036622; rs34565773; rs11267846; rs35839653; rs10071263; rs11747064; rs34385557; rs10072744; rs10074582; rs10074650; rs10463299; rs10476750; rs11951034; rs12109850; rs253290; rs253292; rs2748216; rs2983101; rs3095891; rs3097831; rs4958669; rs753261

# Metabolic_Enzyme_11_General_References:
7601448; 9230113; 10196134

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5520

# Metabolic_Enzyme_12_Name:
Carbohydrate sulfotransferase 13

# Metabolic_Enzyme_12_Synonyms:
Chondroitin 4-O- sulfotransferase 3; Chondroitin 4-sulfotransferase 3; C4ST3; C4ST- 3

# Metabolic_Enzyme_12_Gene_Name:
CHST13

# Metabolic_Enzyme_12_Protein_Sequence:
>Carbohydrate sulfotransferase 13
MGRRCCRRRVLAAACLGAALLLLCAAPRSLRPAFGNRALGSSWLGGEKRSPLQKLYDLDQ
DPRSTLAKVHRQRRDLLNSACSRHSRRQRLLQPEDLRHVLVDDAHGLLYCYVPKVACTNW
KRVLLALSGQARGDPRAISAQEAHAPGRLPSLADFSPAEINRRLRAYLAFLFVREPFERL
ASAYRNKLARPYSAAFQRRYGARIVQRLRPRALPDARARGHDVRFAEFLAYLLDPRTRRE
EPFNEHWERAHALCHPCRLRYDVVGKFETLAEDAAFVLGLAGASDLSFPGPPRPRGAAAS
RDLAARLFRDISPFYQRRLFDLYKMDFLLFNYSAPSYLRLL

# Metabolic_Enzyme_12_Number_of_Residues:
341

# Metabolic_Enzyme_12_Molecular_Weight:
38920

# Metabolic_Enzyme_12_Theoretical_pI:
11.00

# Metabolic_Enzyme_12_GO_Classification:
Not Available

# Metabolic_Enzyme_12_General_Function:
Not Available

# Metabolic_Enzyme_12_Specific_Function:
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan

# Metabolic_Enzyme_12_Pathway:
map00532  Chondroitin / Heparan sulfate biosynthesis;
 map00920  Sulfur metabolism

# Metabolic_Enzyme_12_Reaction:
3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF03567:Sulfotransfer_2

# Metabolic_Enzyme_12_Signals:
1-26

# Metabolic_Enzyme_12_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 2.8.2.5

# Metabolic_Enzyme_12_GenBank_ID_Protein:
22651777

# Metabolic_Enzyme_12_SwissProt_ID:
CHSTD_HUMAN (Q8NET6)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
CHST13

# Metabolic_Enzyme_12_Geneatlas_id:
CHST13

# Metabolic_Enzyme_12_hgnc_id:
HGNC:21755

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_12_Gene_Sequence:
>1026 bp
ATGGGGAGGCGCTGCTGCCGGCGGCGCGTGCTGGCGGCCGCCTGTCTGGGCGCCGCGCTC
CTGCTCCTATGCGCCGCGCCCCGCTCCCTGCGCCCGGCATTTGGAAACAGAGCCCTGGGC
TCCAGCTGGCTTGGTGGGGAGAAGAGAAGCCCCCTGCAGAAGCTCTATGACCTGGATCAG
GACCCGCGCTCGACCCTGGCGAAGGTGCACCGTCAGCGGCGCGACCTGCTGAACAGCGCC
TGTAGCCGCCACTCACGCCGGCAGCGCCTGCTACAGCCGGAGGACCTGCGGCACGTGCTG
GTGGACGACGCGCATGGCCTGCTCTACTGCTACGTGCCCAAGGTGGCCTGCACCAACTGG
AAGCGCGTGCTGCTGGCGCTGAGCGGCCAAGCCCGCGGCGACCCGCGCGCCATCTCCGCG
CAAGAGGCGCACGCGCCTGGCCGCCTGCCCTCACTGGCCGACTTCAGCCCCGCCGAGATC
AACCGGCGCCTGCGCGCCTACTTGGCCTTCCTGTTCGTGCGGGAGCCCTTCGAGCGCCTG
GCATCGGCTTACCGCAACAAGCTCGCGCGCCCCTACAGCGCCGCCTTCCAGAGGCGCTAC
GGTGCACGCATCGTTCAGCGCCTGCGGCCGCGCGCGCTCCCCGACGCCCGGGCCCGCGGC
CACGACGTGCGCTTCGCGGAGTTCCTGGCCTACCTGCTGGACCCGCGCACGCGGCGTGAG
GAGCCCTTCAACGAGCACTGGGAGCGCGCGCACGCGCTCTGCCACCCGTGTCGCCTCCGC
TACGACGTCGTGGGCAAGTTCGAGACGCTGGCGGAGGACGCGGCCTTCGTGCTGGGCCTG
GCGGGCGCATCCGACCTGAGCTTCCCTGGGCCGCCGCGGCCCCGGGGAGCCGCCGCCTCC
CGCGACCTGGCAGCGCGCCTCTTCCGGGACATCAGCCCCTTCTACCAGCGGCGCCTCTTC
GACCTCTACAAGATGGACTTCCTGCTTTTCAACTACTCCGCCCCCTCCTACCTGCGGCTG
CTCTAG

# Metabolic_Enzyme_12_GenBank_ID_Gene:
AY120869

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_12_Locus:
3q21.3

# Metabolic_Enzyme_12_SNPs:
rs1056522; rs34311016; rs1056523; rs1056524; rs6766712; rs7613347; rs6783962; rs3845960; rs3856650; rs1873397; rs6796854; rs2101592; rs4305381; rs12496524; rs1873396; rs1490750; rs4592980; rs1873399; rs1873394; rs4465899; rs1873395; rs1873400; rs1994642; rs6781798; rs1873401; rs9878550; rs11920318; rs4679256; rs1873398; rs6768289; rs12494117; rs11918048; rs1873403; rs744233; rs6764354; rs2363032; rs1602367; rs3732537; rs1994643; rs6786437; rs1388096; rs1388097; rs12495696; rs7614066; rs1054097; rs34862133; rs7616966; rs10670471; rs11403083; rs28670960; rs9828372; rs1873402; rs9827924; rs34424364; rs35702034; rs34585126; rs10576955; rs34933826; rs28478592; rs9865660; rs35748584; rs4679252; rs10576956; rs9871908; rs13071743; rs9828092; rs34228170; rs4377447; rs10622181; rs2087599; rs7610155; rs1552642; rs9828214; rs9851107; rs744232; rs12631430; rs5852485; rs34561357; rs9848138; rs9827789; rs34711384; rs11718493; rs34987672; rs2087598; rs28696000; rs35017523; rs2087600; rs34487087; rs34642700; rs34347129; rs11717719; rs3029123; rs10663876; rs35941669; rs35642580; rs35656703; rs7648094; rs6803635; rs9828089; rs35512178; rs13079087; rs13071710; rs10576954; rs1490749; rs13080948; rs9871756; rs34827577; rs34362118; rs34859935; rs10663877; rs11718066; rs35634058; rs35944702; rs34470861; rs10580329; rs34597652; rs13323871; rs10804576; rs1123373; rs12490724; rs12493410; rs13071443; rs1490747; rs1490748; rs1490751; rs1552641; rs1687479; rs1687480; rs1687481; rs1873392; rs1873393; rs2291509; rs34760151; rs35500716; rs4679125; rs4679259; rs6782739; rs7629573; rs777486; rs869463; rs869464; rs9813564

# Metabolic_Enzyme_12_General_References:
12080076

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5577

# Metabolic_Enzyme_13_Name:
Sulfotransferase 1A1

# Metabolic_Enzyme_13_Synonyms:
Aryl sulfotransferase 1; Phenol sulfotransferase 1; Phenol-sulfating phenol sulfotransferase 1; P- PST 1; Thermostable phenol sulfotransferase; Ts-PST; HAST1/HAST2; ST1A3

# Metabolic_Enzyme_13_Gene_Name:
SULT1A1

# Metabolic_Enzyme_13_Protein_Sequence:
>Sulfotransferase 1A1
MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDM
IYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLD
QKVKVVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWW
ELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETVDFMVQHTSFKEMKKNPMTNY
TTVPQEFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL

# Metabolic_Enzyme_13_Number_of_Residues:
295

# Metabolic_Enzyme_13_Molecular_Weight:
34198

# Metabolic_Enzyme_13_Theoretical_pI:
6.61

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Not Available

# Metabolic_Enzyme_13_Specific_Function:
Catalyzes the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk

# Metabolic_Enzyme_13_Pathway:
map00920  Sulfur metabolism

# Metabolic_Enzyme_13_Reaction:
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
None

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 2.8.2.1

# Metabolic_Enzyme_13_GenBank_ID_Protein:
179042

# Metabolic_Enzyme_13_SwissProt_ID:
ST1A1_HUMAN (P50225)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
SULT1A1

# Metabolic_Enzyme_13_Geneatlas_id:
SULT1A1

# Metabolic_Enzyme_13_hgnc_id:
HGNC:11453

# Metabolic_Enzyme_13_PDB_ID:
1LS6

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_13_Gene_Sequence:
>888 bp
ATGGAGCTGATCCAGGACACCTCCCGCCCGCCACTGGAGTACGTGAAGGGGGTCCCGCTC
ATCAAGTACTTTGCAGAGGCACTGGGGCCCCTGCAGAGCTTCCAGGCCCGGCCTGATGAC
CTGCTCATCAGCACCTACCCCAAGTCCGGCACCACCTGGGTGAGCCAGATTCTGGACATG
ATCTACCAGGGTGGTGACCTGGAGAAGTGTCACCGAGCTCCCATCTTCATGCGGGTGCCC
TTCCTTGAGTTCAAAGCCCCAGGGATTCCCTCAGGGATGGAGACTCTGAAAGACACACCG
GCCCCACGACTCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGAT
CAGAAGGTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGGATGTGGCAGTTTCCTACTAC
CACTTCTACCACATGGCCAAGGTGCACCCTGAGCCTGGGACCTGGGACAGCTTCCTGGAG
AAGTTCATGGTCGGAGAAGTGTCCTACGGATCCTGGTACCAGCACGTGCAGGAGTGGTGG
GAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCC
AAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCACTCCCTGCCAGAGGAGACCGTG
GACTTCATGGTTCAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTAC
ACCACCGTCCCCCAGGAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATG
GCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTAT
GCGGAGAAGATGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
L10819

# Metabolic_Enzyme_13_Chromosome_Location:
Not Available

# Metabolic_Enzyme_13_Locus:
Not Available

# Metabolic_Enzyme_13_SNPs:
Not Available

# Metabolic_Enzyme_13_General_References:
8484775; 8363592; 7864863; 8423770; 7695643; 7581483; 8033246; 8924211; 9855620; 8288252; 8093002; 8033270; 9345314; 10762004

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5592

# Metabolic_Enzyme_14_Name:
Monoamine-sulfating phenol sulfotransferase

# Metabolic_Enzyme_14_Synonyms:
Aryl sulfotransferase 1A3; Sulfotransferase, monoamine-preferring; M-PST; Thermolabile phenol sulfotransferase; TL-PST; Placental estrogen sulfotransferase; Catecholamine-sulfating phenol sulfotransferase; HAST3

# Metabolic_Enzyme_14_Gene_Name:
SULT1A3

# Metabolic_Enzyme_14_Protein_Sequence:
>Monoaminesulfating phenol sulfotransferase
MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLINTYPKSGTTWVSQILDM
IYQGGDLEKCNRAPIYVRVPFLEVNDPGEPSGLETLKDTPPPRLIKSHLPLALLPQTLLD
QKVKVVYVARNPKDVAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWW
ELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETMDFMVQHTSFKEMKKNPMTNY
TTVPQELMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL

# Metabolic_Enzyme_14_Number_of_Residues:
295

# Metabolic_Enzyme_14_Molecular_Weight:
34197

# Metabolic_Enzyme_14_Theoretical_pI:
5.88

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Not Available

# Metabolic_Enzyme_14_Specific_Function:
Catalyzes the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs

# Metabolic_Enzyme_14_Pathway:
map00920  Sulfur metabolism

# Metabolic_Enzyme_14_Reaction:
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_14_Signals:
None

# Metabolic_Enzyme_14_Transmembrane_Regions:
None

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 2.8.2.1

# Metabolic_Enzyme_14_GenBank_ID_Protein:
306457

# Metabolic_Enzyme_14_SwissProt_ID:
ST1A3_HUMAN (P50224)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
SULT1A3

# Metabolic_Enzyme_14_Geneatlas_id:
SULT1A3

# Metabolic_Enzyme_14_hgnc_id:
HGNC:11455

# Metabolic_Enzyme_14_PDB_ID:
1CJM

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_14_Gene_Sequence:
>888 bp
ATGGAGCTGATCCAGGACACCTCCCGCCCGCCACTGGAGTACGTGAAGGGGGTCCCGCTC
ATCAAGTACTTTGCAGAGGCACTGGGGCCCCTGCAGAGCTTCCAAGCCCGACCTGATGAC
CTGCTCATCAACACCTACCCCAAGTCTGGCACCACCTGGGTGAGCCAGATACTGGACATG
ATCTACCAGGGCGGCGACCTAGAGAAGTGTAACCGGGCTCCCATCTACGTACGGGTGCCC
TTCCTTGAGGTCAATGATCCAGGGGAACCCTCAGGGCTGGAGACTCTGAAAGACACACCG
CCCCCACGGCTCATCAAGTCACACCTGCCCCTGGCTCTGCTCCCTCAGACTCTGTTGGAT
CAGAAGGTCAAGGTGGTCTATGTTGCCCGAAACCCAAAGGACGTGGCGGTCTCCTACTAC
CATTTCCACCGTATGGAAAAGGCGCACCCTGAGCCTGGGACCTGGGACAGCTTCCTGGAA
AAGTTCATGGCTGGAGAAGTGTCCTACGGGTCCTGGTACCAGCACGTGCAGGAGTGGTGG
GAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCC
AAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACCATG
GACTTCATGGTTCAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTAC
ACCACCGTCCCCCAGGAGCTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATG
GCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTAT
GCGGAGAAGATGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGA

# Metabolic_Enzyme_14_GenBank_ID_Gene:
L19956

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_14_Locus:
16p11.2

# Metabolic_Enzyme_14_SNPs:
Not Available

# Metabolic_Enzyme_14_General_References:
8363592; 8187949; 7802665; 8117269; 7695637; 7695643; 7961757; 7829089; 8093002; 10543947

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5519

# Metabolic_Enzyme_15_Name:
Carbohydrate sulfotransferase 3

# Metabolic_Enzyme_15_Synonyms:
Chondroitin 6- sulfotransferase; Chondroitin 6-O-sulfotransferase 1; C6ST-1; C6ST; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O- sulfotransferase 0; GST-0

# Metabolic_Enzyme_15_Gene_Name:
CHST3

# Metabolic_Enzyme_15_Protein_Sequence:
>Carbohydrate sulfotransferase 3
MEKGLTLPQDCRDFVHSLKMRSKYALFLVFVVIVFVFIEKENKIISRVSDKLKQIPQALA
DANSTDPALILAENASLLSLSELDSAFSQLQSRLRNLSLQLGVEPAMEAAGEEEEEQRKE
EEPPRPAVAGPRRHVLLMATTRTGSSFVGEFFNQQGNIFYLFEPLWHIERTVSFEPGGAN
AAGSALVYRDVLKQLFLCDLYVLEHFITPLPEDHLTQFMFRRGSSRSLCEDPVCTPFVKK
VFEKYHCKNRRCGPLNVTLAAEACRRKEHMALKAVRIRQLEFLQPLAEDPRLDLRVIQLV
RDPRAVLASRMVAFAGKYKTWKKWLDDEGQDGLREEEVQRLRGNCESIRLSAELGLRQPA
WLRGRYMLVRYEDVARGPLQKAREMYRFAGIPLTPQVEDWIQKNTQAAHDGSGIYSTQKN
SSEQFEKWRFSMPFKLAQVVQAACGPAMRLFGYKLARDAAALTNRSVSLLEERGTFWVT

# Metabolic_Enzyme_15_Number_of_Residues:
479

# Metabolic_Enzyme_15_Molecular_Weight:
54707

# Metabolic_Enzyme_15_Theoretical_pI:
8.75

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Not Available

# Metabolic_Enzyme_15_Specific_Function:
Catalyzes the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen

# Metabolic_Enzyme_15_Pathway:
map00532  Chondroitin / Heparan sulfate biosynthesis

# Metabolic_Enzyme_15_Reaction:
3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_15_Signals:
1-38

# Metabolic_Enzyme_15_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 2.8.2.17

# Metabolic_Enzyme_15_GenBank_ID_Protein:
3510308

# Metabolic_Enzyme_15_SwissProt_ID:
CHST3_HUMAN (Q7LGC8)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
CHST3

# Metabolic_Enzyme_15_Geneatlas_id:
CHST3

# Metabolic_Enzyme_15_hgnc_id:
HGNC:1971

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_15_Gene_Sequence:
>1440 bp
ATGGAGAAAGGACTCACTTTGCCCCAGGACTGCCGGGACTTTGTGCACAGCCTGAAGATG
AGAAGCAAATACGCCCTTTTCTTGGTTTTTGTGGTGATAGTTTTTGTCTTCATCGAAAAG
GAAAATAAAATCATATCAAGGGTCTCAGACAAGCTGAAGCAGATTCCCCAAGCTCTAGCA
GATGCCAACAGCACCGACCCAGCCCTGATCTTAGCTGAGAACGCATCTCTCTTGTCCCTG
AGCGAGCTCGATTCAGCCTTCTCCCAGCTTCAGAGCCGTCTCCGCAACCTCAGCTTGCAG
CTGGGCGTGGAGCCAGCCATGGAGGCCGCAGGGGAGGAAGAGGAAGAGCAGAGAAAGGAG
GAGGAGCCGCCCAGACCGGCCGTGGCGGGGCCCCGGCGCCACGTGCTGCTCATGGCCACC
ACGCGCACCGGCTCCTCGTTCGTGGGCGAGTTCTTCAACCAGCAGGGCAACATCTTCTAC
CTCTTCGAGCCGCTGTGGCACATCGAGCGCACAGTGTCCTTCGAGCCGGGGGGCGCCAAC
GCCGCGGGCTCGGCCCTGGTGTACCGCGACGTGCTCAAGCAGCTCTTCCTGTGCGACCTG
TACGTGCTGGAGCACTTCATCACGCCGCTGCCCGAGGACCACCTGACTCAGTTCATGTTC
CGCCGGGGCTCCAGCCGCTCCCTGTGCGAGGACCCCGTCTGTACGCCCTTCGTCAAGAAG
GTCTTCGAGAAGTACCACTGCAAGAACCGCCGCTGCGGCCCCCTCAACGTGACGCTGGCC
GCAGAGGCCTGCCGCCGCAAGGAGCACATGGCCCTCAAGGCGGTGCGCATCCGGCAGCTG
GAGTTCCTGCAGCCGCTGGCCGAGGACCCCCGCCTGGACCTGCGCGTCATCCAGCTGGTG
CGCGACCCCCGGGCCGTGCTGGCCTCGCGCATGGTGGCCTTCGCCGGCAAGTATAAGACC
TGGAAGAAGTGGCTGGACGACGAGGGCCAGGACGGCCTGAGGGAAGAGGAGGTGCAGCGG
CTGCGGGGCAACTGCGAGAGCATCCGCCTGTCCGCGGAGCTGGGGCTGCGGCAGCCCGCC
TGGCTGCGGGGCCGCTACATGCTGGTGCGCTACGAGGACGTGGCACGCGGGCCGCTGCAG
AAGGCCCGCGAGATGTACCCGTTCGCCGGCATCCCCCTGACCCCGCAGGTGGAAGACTGG
ATCCAAAAGAACACGCAGGCGGCCCACGACGGCAGCGGCATCTACTCCACGCAGAAGAAC
TCCTCGGAGCAGTTCGAGAAGTGGCGCTTCAGCATGCCCTTCAAGCTGGCCCAGGTGGTG
CAGGCCCCGTGCGGCCCTGCCATGCGCCTCTTCGGCTACAAACTGGCGCGGGACGCCGCC
GCCCTCACCAACCGCTCAGTCAGCCTGCTGGAGGAGAGGGGCACCTTCTGGGTCACGTAG


# Metabolic_Enzyme_15_GenBank_ID_Gene:
AB012192

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_15_Locus:
10q22.1

# Metabolic_Enzyme_15_SNPs:
rs1871452; rs731027; rs751450; rs874692; rs4148946; rs4148941; rs4148917; rs4148949; rs4148913; rs1007242; rs730720; rs4148911; rs7085958; rs4148947; rs4746104; rs4148929; rs12418; rs4148950; rs4747229; rs11816049; rs10400065; rs2127357; rs10400095; rs4148907; rs7894517; rs4148951; rs4148912; rs2219836; rs2091331; rs4747228; rs4148928; rs1871451; rs4148953; rs2394847; rs4148944; rs1006974; rs4148919; rs4148909; rs2219837; rs4148915; rs11000124; rs10400064; rs4148926; rs7894831; rs10762498; rs7894516; rs730334; rs7907616; rs11000125; rs10823895; rs4148914; rs16929534; rs4148930; rs6480592; rs4746103; rs16929536; rs4148923; rs4747234; rs1871450; rs4747235; rs10823894; rs7912541; rs4747231; rs2127358; rs4148927; rs16929537; rs12413786; rs4284332; rs4148938; rs4600132; rs12263208; rs4747230; rs4148932; rs4148937; rs4148936; rs7086629; rs4148925; rs7097834; rs2394849; rs4148910; rs11000123; rs730722; rs9783245; rs6480590; rs4148933; rs4148943; rs4148920; rs12258400; rs17297481; rs2091332; rs4148935; rs11818951; rs4148948; rs4148918; rs4148945; rs4746105; rs6480591; rs9783244; rs11000128; rs751451; rs12248756; rs4148940; rs11000129; rs6480589; rs10823898; rs10823892; rs4747226; rs10740394; rs3808945; rs7478499; rs28937593; rs3740128; rs3740129; rs34576849; rs3062567; rs10653065; rs12246941; rs4148934; rs12766680; rs35017952; rs35366073; rs5786057; rs12250841; rs3062561; rs12266892; rs12782413; rs4148939; rs34065464; rs28544949; rs4148956; rs7070479; rs4148922; rs12258502; rs1880685; rs12250549; rs4148942; rs16929522; rs35928289; rs11000126; rs2394848; rs12267478; rs35954993; rs12249337; rs36075587; rs10554998; rs34158877; rs35863653; rs12766209; rs4148908; rs10625888; rs4148924; rs4148957; rs34887527; rs34938931; rs34828900; rs4747236; rs7090835; rs35930224; rs17646780; rs12261847; rs17714398; rs11418501; rs34880981; rs4148916; rs10399980; rs35358037; rs7099356; rs34185338; rs3998500; rs4747232; rs10688056; rs730721; rs2394850; rs12172746; rs12267929; rs10400130; rs2140928; rs28691586; rs4148931; rs34975752; rs10564775; rs35809559; rs5786058; rs11306241; rs7072219; rs7898082; rs4148921; rs34734518; rs11598628; rs11424498; rs41448348; rs11000131; rs11000133; rs3808944; rs34740711; rs3840752; rs1817357; rs4148954; rs11000116; rs11000122; rs11000134; rs11000136; rs12243372; rs12250354; rs12414428; rs1245581; rs1245582; rs1245584; rs16929563; rs34357469; rs7081747; rs7085814; rs7895905; rs896076; rs896077; rs896078

# Metabolic_Enzyme_15_General_References:
9714738; 9883891

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5586

# Metabolic_Enzyme_16_Name:
Sulfotransferase 1A2

# Metabolic_Enzyme_16_Synonyms:
Aryl sulfotransferase 2; Phenol sulfotransferase 2; Phenol-sulfating phenol sulfotransferase 2; P- PST 2; ST1A2

# Metabolic_Enzyme_16_Gene_Name:
SULT1A2

# Metabolic_Enzyme_16_Protein_Sequence:
>Sulfotransferase 1A2
MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDM
IYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGMETLKNTPAPRLLKTHLPLALLPQTLLD
QKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWW
ELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKTPMTNY
TTVRREFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL

# Metabolic_Enzyme_16_Number_of_Residues:
295

# Metabolic_Enzyme_16_Molecular_Weight:
34286

# Metabolic_Enzyme_16_Theoretical_pI:
7.32

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Not Available

# Metabolic_Enzyme_16_Specific_Function:
Catalyzes the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk

# Metabolic_Enzyme_16_Pathway:
map00920  Sulfur metabolism

# Metabolic_Enzyme_16_Reaction:
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_16_Signals:
None

# Metabolic_Enzyme_16_Transmembrane_Regions:
None

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 2.8.2.1

# Metabolic_Enzyme_16_GenBank_ID_Protein:
881505

# Metabolic_Enzyme_16_SwissProt_ID:
ST1A2_HUMAN (P50226)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
SULT1A2

# Metabolic_Enzyme_16_Geneatlas_id:
SULT1A2

# Metabolic_Enzyme_16_hgnc_id:
HGNC:11454

# Metabolic_Enzyme_16_PDB_ID:
1LS6

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_16_Gene_Sequence:
>888 bp
ATGGAGCTGATCCAGGACACCTCCCGCCCGCCACTGGAGTACGTGAAGGGGGTCCCGCTC
ATCAAGTACTTTGCAGAGGCACTGGGGCCCCTGCAGAGCTTCCAGGCCCGGCCTGATGAC
CTGCTCATCAGCACCTACCCCAAGTCCGGCACCACCTGGGTGAGCCAGATTCTGGACATG
ATCTACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCATCTTCATGCGGGTGCCC
TTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGGATGGAGACTCTGAAAAACACACCA
GCCCCACGACTCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGAT
CAGAAGGTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGGATGTGGCGGTTTCCTACTAC
CACTTCTACCACATGGCCAAAGTGTACCCTCACCCTGGGACCTGGGAAAGCTTCCTGGAG
AAGTTCATGGCTGGAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAGTGGTGG
GAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCC
AAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACTGTG
GACCTCATGGTTGAGCACACGTCGTTCAAGGAGATGAAGAAGACCCCTATGACCAACTAC
ACCACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATG
GCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTAT
GCGGAGAAGATGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
U28170

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_16_Locus:
16p12.1

# Metabolic_Enzyme_16_SNPs:
rs10797300; rs1059491; rs4987024; rs1126451; rs1136703; rs1042041; rs1041986; rs1690407; rs4987224; rs1126449; rs1041982; rs193652; rs743590; rs11074908; rs2088727; rs4115668; rs8053666; rs1697021; rs11863334; rs34923751; rs762633; rs1690404; rs3743963; rs4149406; rs193654; rs12920841; rs11647881; rs12445519; rs4149398; rs9921771; rs12445705; rs11643450; rs35750053; rs34699167; rs34245479; rs1690403; rs762632; rs8052446; rs28444394; rs4149403; rs11389196; rs193653; rs35214418; rs1697022; rs4149407; rs9937476; rs11643332; rs11648872; rs28640890; rs4787453; rs11643457; rs11643336; rs28683100; rs11643411; rs4149377; rs4149399; rs1042005; rs10521145; rs1062482; rs11074904; rs11074907; rs11401; rs11569775; rs13339053; rs16940492; rs17707300; rs193648; rs2077031; rs2291937; rs2291938; rs3020805; rs3020806; rs3020810; rs36043491; rs4149408; rs4149409; rs4788069; rs4788073; rs4788074; rs7499134; rs8054973; rs9939264; rs9941096; rs9941199

# Metabolic_Enzyme_16_General_References:
7581483; 8033246; 8661000; 9119390; 7889867; 10762004

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5579

# Metabolic_Enzyme_17_Name:
Heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor

# Metabolic_Enzyme_17_Synonyms:
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1; Heparan sulfate 3-O-sulfotransferase 1; h3-OST-1

# Metabolic_Enzyme_17_Gene_Name:
HS3ST1

# Metabolic_Enzyme_17_Protein_Sequence:
>Heparan sulfate glucosamine 3Osulfotransferase 1 precursor
MAALLLGAVLLVAQPQLVPSRPAELGQQELLRKAGTLQDDVRDGVAPNGSAQQLPQTIII
GVRKGGTRALLEMLSLHPDVAAAENEVHFFDWEEHYSHGLGWYLSQMPFSWPHQLTVEKT
PAYFTSPKVPERVYSMNPSIRLLLILRDPSERVLSDYTQVFYNHMQKHKPYPSIEEFLVR
DGRLNVDYKALNRSLYHVHMQNWLRFFPLRHIHIVDGDRLIRDPFPEIQKVERFLKLSPQ
INASNFYFNKTKGFYCLRDSGRDRCLHESKGRAHPQVDPKLLNKLHEYFHEPNKKFFELV
GRTFDWH

# Metabolic_Enzyme_17_Number_of_Residues:
307

# Metabolic_Enzyme_17_Molecular_Weight:
35773

# Metabolic_Enzyme_17_Theoretical_pI:
9.16

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Not Available

# Metabolic_Enzyme_17_Specific_Function:
Rate limiting enzyme for synthesis of HSact. Performs the crucial step modification in the biosynthesis of anticoagulant heparan sulfate (HSact) that is to complete the structure of the antithrombin pentasaccharide binding site

# Metabolic_Enzyme_17_Pathway:
map00532  Chondroitin / Heparan sulfate biosynthesis

# Metabolic_Enzyme_17_Reaction:
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_17_Signals:
1-20

# Metabolic_Enzyme_17_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 2.8.2.23

# Metabolic_Enzyme_17_GenBank_ID_Protein:
2618973

# Metabolic_Enzyme_17_SwissProt_ID:
OST1_HUMAN (O14792)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
HS3ST1

# Metabolic_Enzyme_17_Geneatlas_id:
HS3ST1

# Metabolic_Enzyme_17_hgnc_id:
HGNC:5194

# Metabolic_Enzyme_17_PDB_ID:
1VKJ

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Golgi apparatus; Golgi apparatus lumen (Probable)

# Metabolic_Enzyme_17_Gene_Sequence:
>924 bp
ATGGCCGCGCTGCTCCTGGGCGCGGTGCTGCTGGTGGCCCAGCCCCAGCTAGTGCCTTCC
CGCCCCGCCGAGCTAGGCCAGCAGGAGCTTCTGCGGAAAGCGGGGACCCTCCAGGATGAC
GTCCGCGATGGCGTGGCCCCAAACGGCTCTGCCCAGCAGTTGCCGCAGACCATCATCATC
GGCGTGCGCAAGGGCGGCACGCGCGCACTGCTGGAGATGCTCAGCCTGCACCCCGACGTG
GCGGCCGCGGAGAACGAGGTCCACTTCTTCGACTGGGAGGAGCATTACAGCCACGGCTTG
GGCTGGTACCTCAGCCAGATGCCCTTCTCCTGGCCACACCAGCTCACAGTGGAGAAGACC
CCCGCGTATTTCACGTCGCCCAAAGTGCCTGAGCGAGTCTACAGCATGAACCCGTCCATC
CGGCTGCTGCTCATCCTGCGAGACCCGTCGGAGCGCGTGCTATCTGACTACACCCAAGTG
TTCTACAACCACATGCAGAAGCACAAGCCCTACCCGTCCATCGAGGAGTTCCTGGTGCGC
GATGGCAGGCTCAATGTGGACTACAAGGCCCTCAACCGCAGCCTCTACCACGTGCACATG
CAGAACTGGCTGCGCTTTTTCCCGCTGCGCCACATCCACATTGTGGACGGCGACCGCCTC
ATCAGGGACCCCTTCCCTGAGATCCAAAAGGTCGAGAGGTTCCTAAAGCTGTCGCCGCAG
ATCAATGCTTCGAACTTCTACTTTAACAAAACCAAGGGCTTTTACTGCCTGCGGGACAGC
GGCCGGGACCGCTGCTTACATGAGTCCAAAGGCCGGGCGCACCCCCAAGTCGATCCCAAA
CTACTCAATAAACTGCACGAATATTTTCATGAGCCAAATAAGAAGTTCTTCGAGCTTGTT
GGCAGAACATTTGACTGGCACTGA

# Metabolic_Enzyme_17_GenBank_ID_Gene:
AF019386

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_17_Locus:
4p16

# Metabolic_Enzyme_17_SNPs:
rs34719057; rs1047385; rs1047389; rs224458; rs224492; rs224491; rs224462; rs1406076; rs10939297; rs10939293; rs224460; rs7655727; rs7660531; rs7674470; rs224463; rs7660733; rs224493; rs224464; rs224490; rs11737688; rs4697689; rs7664208; rs11943833; rs12512219; rs7696706; rs10028046; rs123631; rs1072192; rs9992896; rs764111; rs16881554; rs17488994; rs6811800; rs12651453; rs12054490; rs13135853; rs9990914; rs10002690; rs9999523; rs6827436; rs874313; rs17488959; rs2109600; rs16881406; rs16881384; rs16881670; rs16881661; rs224459; rs11724878; rs16881663; rs16881605; rs16881480; rs224465; rs17488722; rs16881495; rs17423177; rs16881652; rs16881636; rs16881393; rs17423099; rs4305508; rs16881629; rs16881657; rs17423205; rs16881642; rs16881477; rs224461; rs10939298; rs16881446; rs224489; rs1528081; rs11559238; rs34551111; rs36156111; rs10551041; rs4432742; rs35302053; rs3070505; rs36083371; rs4423867; rs10569171; rs224467; rs28623069; rs10564680; rs34938060; rs34468148; rs10000547; rs36016983; rs10000548; rs34741896; rs11559237; rs16881540; rs4697887; rs34775772; rs33924139; rs10010953; rs34574311; rs10598868; rs16881451; rs35987774; rs9997190; rs35587466; rs5856099; rs123630; rs10000714; rs224456; rs35736829; rs11343014; rs35790387; rs10008429; rs1072191; rs6813342; rs224457; rs10031750; rs10008347; rs35547086; rs34339429; rs35191148; rs34511118; rs5856100; rs34997792; rs34441222; rs10616469; rs34521656; rs10012344; rs1013274; rs1013275; rs1024034; rs1024035; rs10488975; rs10939286; rs11724954; rs11728089; rs11728263; rs11731587; rs11931585; rs11936371; rs11941536; rs12511394; rs12644896; rs13107815; rs13114517; rs13124320; rs13127396; rs13127432; rs13144726; rs16881318; rs2240901; rs224484; rs224485; rs224486; rs224487; rs224488; rs4697688; rs4697885; rs6818632; rs6827485; rs6828761; rs6840661; rs722212; rs722213; rs7663872; rs991085; rs991086

# Metabolic_Enzyme_17_General_References:
9346953; 8900198; 9988768; 9988767

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5583

# Metabolic_Enzyme_18_Name:
Bile salt sulfotransferase

# Metabolic_Enzyme_18_Synonyms:
Hydroxysteroid Sulfotransferase; HST; Dehydroepiandrosterone sulfotransferase; DHEA-ST; ST2; ST2A3

# Metabolic_Enzyme_18_Gene_Name:
SULT2A1

# Metabolic_Enzyme_18_Protein_Sequence:
>Bile salt sulfotransferase
MSDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSK
GDAKWIQSVP
IWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYL
MRNPRDVLVSGYFFWKNMKFI
KKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKN
FLLLSYEELKQDTGRTIEKICQFLGKTLEPEE
LNLILKNSSFQSMKENKMSNYSLLSVD
YVVDKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRE
LFPWE

# Metabolic_Enzyme_18_Number_of_Residues:
285

# Metabolic_Enzyme_18_Molecular_Weight:
33780

# Metabolic_Enzyme_18_Theoretical_pI:
5.76

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Not Available

# Metabolic_Enzyme_18_Specific_Function:
Catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands

# Metabolic_Enzyme_18_Pathway:
Not Available

# Metabolic_Enzyme_18_Reaction:
3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_18_Signals:
None

# Metabolic_Enzyme_18_Transmembrane_Regions:
None

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 2.8.2.14

# Metabolic_Enzyme_18_GenBank_ID_Protein:
306702

# Metabolic_Enzyme_18_SwissProt_ID:
ST2A1_HUMAN (Q06520)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
SULT2A1

# Metabolic_Enzyme_18_Geneatlas_id:
SULT2A1

# Metabolic_Enzyme_18_hgnc_id:
HGNC:11458

# Metabolic_Enzyme_18_PDB_ID:
1OV4

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_18_Gene_Sequence:
>858 bp

ATGTCGGACGATTTCTTATGGTTTGAAGGCATAGCTTTCCCTACTATGGGTTTCAGATC
CGAAACCTTAA
GAAAAGTACGTGATGAGTTCGTGATAAGGGATGAAGATGTAATAATAT
TGACTTACCCCAAATCAGGAAC
AAACTGGTTGGCTGAGATTCTCTGCCTGATGCACTCC
AAGGGGGATGCCAAGTGGATCCAATCTGTGCCC
ATCTGGGAGCGATCACCCTGGGTAGA
GAGTGAGATTGGGTATACAGCACTCAGTGAAAGCGAGAGTCCAC
GTTTATTCTCCTCCC
ACCTCCCCATCCAGTTATTCCCCAAGTCTTTCTTCAGTTCCAAGGCCAAGGTGAT
TTAT
CTCATGAGAAATCCCAGAGATGTTTTGGTGTCTGGTTATTTTTTCTGGAAAAACATGAAG
TTTATT
AAGAAACCAAAGTCATGGGAAGAATATTTTGAATGGTTTTGTCAAGGAACTGT
GCTATATGGGTCATGGT
TTGACCACATTCATGGCTGGATGCCCATGAGAGAGGAGAAAA
ACTTCCTGTTACTGAGTTATGAGGAGCT
GAAACAGGACACAGGAAGAACCATAGAGAAG
ATCTGTCAATTCCTGGGAAAGACGTTAGAACCCGAAGAA
CTGAACTTAATTCTCAAGAA
CAGCTCCTTTCAGAGCATGAAAGAAAACAAGATGTCCAATTATTCCCTCC
TGAGTGTTG
ATTATGTAGTGGACAAAGCACAACTTCTGAGAAAAGGTGTATCTGGGGACTGGAAAAATC
A
CTTCACAGTGGCCCAAGCTGAAGACTTTGATAAATTGTTCCAAGAGAAGATGGCAGAT
CTTCCTCGAGAG
CTGTTCCCATGGGAATAA

# Metabolic_Enzyme_18_GenBank_ID_Gene:
L20000

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_18_Locus:
19q13.3

# Metabolic_Enzyme_18_SNPs:
rs11569681; rs11569679; rs11569685; rs11083907; rs296365; rs11083903; rs296366; rs296367; rs2547238; rs2547241; rs212099; rs4149448; rs2910394; rs2547236; rs11083905; rs11671690; rs2547240; rs11083904; rs2637116; rs296364; rs2431829; rs296361; rs2431828; rs2431830; rs2547237; rs2910393; rs11083906; rs4149452; rs10425629; rs10426201; rs296362; rs10401763; rs296359; rs296363; rs2547235; rs7247968; rs9676884; rs212100; rs8113396; rs2547242; rs2451834; rs2547231; rs12461808; rs10425975; rs2547239; rs8108674; rs16972519; rs10420308; rs4149449; rs10425154; rs7256697; rs182420; rs296368; rs188440; rs2932766; rs10401229; rs7508610; rs10402030; rs17464626; rs177037; rs17851828; rs1131405; rs1131404; rs4149454; rs10416994; rs36012387; rs10676904; rs10048437; rs34884527; rs10697302; rs35135607; rs11668504; rs10425963; rs35486252; rs36196588; rs35795715; rs12461162; rs7251378; rs12985420; rs35150217; rs4149451; rs34559609; rs34468125; rs34642376; rs34027366; rs34692560; rs9304669; rs4149450; rs2637115; rs2547234; rs11352410; rs34339793; rs12151061; rs12975483; rs3936308; rs35243293; rs296360; rs2547233; rs2972624; rs35067360; rs28830294; rs2972622; rs35543847; rs35489406; rs4002939; rs35975330; rs177036; rs2910392; rs2972623; rs28505302; rs28762460; rs8104798; rs11569677; rs11569678; rs11569680; rs11569683; rs11569684; rs12461421; rs2547229; rs2910397; rs2910400; rs296381; rs296390; rs296391; rs296394; rs2972612; rs6509347; rs6509348; rs8105359

# Metabolic_Enzyme_18_General_References:
7678732; 1588921; 7589785; 7598806; 7710689; 1520333

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5578

# Metabolic_Enzyme_19_Name:
3'(2'),5'-bisphosphate nucleotidase 1

# Metabolic_Enzyme_19_Synonyms:
Bisphosphate 3'- nucleotidase 1; PAP-inositol-1,4-phosphatase; PIP

# Metabolic_Enzyme_19_Gene_Name:
BPNT1

# Metabolic_Enzyme_19_Protein_Sequence:
>3'2',5'bisphosphate nucleotidase 1
MASSNTVLMRLVASAYSIAQKAGMIVRRVIAEGDLGIVEKTCATDLQTKADRLAQMSICS
SLARKFPKLTIIGEEDLPSEEVDQELIEDSQWEEILKQPCPSQYSAIKEEDLVVWVDPLD
GTKEYTEGLLDNVTVLIGIAYEGKAIAGVINQPYYNYEAGPDAVLGRTIWGVLGLGAFGF
QLKEVPAGKHIITTTRSHSNKLVTDCVAAMNPDAVLRVGGAGNKIIQLIEGKASAYVFAS
PGCKKWDTCAPEVILHAVGGKLTDIHGNVLQYHKDVKHMNSAGVLATLRNYDYYASRVPE
SIKNALVP

# Metabolic_Enzyme_19_Number_of_Residues:
308

# Metabolic_Enzyme_19_Molecular_Weight:
33393

# Metabolic_Enzyme_19_Theoretical_pI:
5.41

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  inositol or phosphatidylinositol phosphatase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_19_Specific_Function:
Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4- trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6

# Metabolic_Enzyme_19_Pathway:
map00920  Sulfur metabolism

# Metabolic_Enzyme_19_Reaction:
adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF00459:Inositol_P

# Metabolic_Enzyme_19_Signals:
1-19

# Metabolic_Enzyme_19_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 3.1.3.7

# Metabolic_Enzyme_19_GenBank_ID_Protein:
4325316

# Metabolic_Enzyme_19_SwissProt_ID:
BPNT1_HUMAN (O95861)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
BPNT1

# Metabolic_Enzyme_19_Geneatlas_id:
BPNT1

# Metabolic_Enzyme_19_hgnc_id:
HGNC:1096

# Metabolic_Enzyme_19_PDB_ID:
1JP4

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_19_Gene_Sequence:
>927 bp
ATGGCTTCCAGTAACACTGTGTTGATGCGGTTGGTAGCCTCCGCATATTCTATTGCTCAA
AAGGCAGGAATGATAGTCAGACGTGTTATTGCTGAAGGAGACCTGGGTATTGTGGAGAAG
ACCTGTGCAACAGACCTGCAGACCAAAGCTGACCGATTGGCACAGATGAGCATATGTTCT
TCATTGGCCCGGAAATTCCCCAAACTCACAATTATAGGGGAAGAGGATCTGCCTTCTGAG
GAAGTGGATCAAGAGCTGATTGAAGACAGTCAGTGGGAAGAAATACTGAAGCAACCATGC
CCATCGCAGTACAGTGCTATTAAAGAAGAAGATCTCGTGGTCTGGGTTGATCCTCTGGAT
GGAACCAAGGAATATACCGAAGGTCTTCTTGACAATGTAACAGTTCTTATTGGAATTGCT
TATGAAGGAAAAGCCATAGCAGGAGTTATTAACCAGCCATATTACAACTATGAGGCAGGA
CCAGATGCTGTGTTGGGGAGGACAATCTGGGGAGTTTTAGGTTTAGGCGCCTTTGGGTTT
CAGCTGAAAGAAGTCCCTGCTGGGAAACACATTATCACAACTACTCGATCCCATAGCAAC
AAGTTGGTTACTGACTGTGTTGCTGCTATGAACCCCGATGCTGTGCTGCGAGTAGGAGGA
GCAGGAAATAAGATTATTCAGCTGATTGAAGGCAAAGCCTCTGCTTATGTATTTGCAAGT
CCTGGTTGTAAGAAGTGGGATACTTGTGCTCCAGAAGTTATTTTACATGCTGTGGGAGGC
AAGTTAACCGATATCCATGGGAATGTTCTTCAGTACCACAAGGATGTGAAGCATATGAAC
TCTGCAGGAGTCCTGGCCACACTGAGGAATTATGACTACTATGCAAGCCGAGTTCCAGAA
TCTATTAAAAATGCACTTGTTCCTTAA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
AF125042

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_19_Locus:
1q41

# Metabolic_Enzyme_19_SNPs:
rs904327; rs2647471; rs2647472; rs2789785; rs12133210; rs2647465; rs2889876; rs12568334; rs6661761; rs6704420; rs12136801; rs1146773; rs904328; rs2053250; rs1146774; rs17563262; rs12116864; rs1611863; rs6673800; rs12145672; rs12135677; rs34406824; rs7524161; rs11586452; rs2577152; rs11803960; rs2647466; rs7538757; rs12734813; rs12407434; rs35038735; rs12404973; rs12086370; rs34887640; rs3201549; rs12138628; rs12408053; rs12410587; rs35675420; rs1137752; rs34639450; rs12046760; rs1137753; rs2577132; rs3055553; rs9431224; rs12081255; rs2577133; rs10702348; rs3201546; rs2577131; rs12037811; rs3055555; rs34628672; rs2789786; rs17856551; rs1051435; rs35221551; rs11118493; rs35619743; rs12033581; rs12038562; rs6667047; rs12726102; rs35685939; rs12757995; rs7516345; rs7530481; rs11292010; rs34257886; rs41274792; rs9430910; rs4268361; rs17856552; rs35431487; rs9969996; rs2486327; rs41274790; rs9430911; rs34136285; rs34674672; rs34025792; rs2247212; rs41274794; rs35600968; rs2577135; rs35546692; rs11405609; rs9430912; rs1612813; rs34118944; rs7515463; rs2789787; rs7531190; rs35894683; rs34255218; rs10648388; rs28445890; rs9430913; rs34672561; rs12066555; rs12026465; rs7531770; rs35677563; rs34649864; rs34638408; rs12127171; rs10157645; rs17007107; rs34116851; rs34980841; rs7516830; rs7549576

# Metabolic_Enzyme_19_General_References:
10224133

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
5587

# Metabolic_Enzyme_20_Name:
Heparan sulfate glucosamine 3-O-sulfotransferase 5

# Metabolic_Enzyme_20_Synonyms:
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5; Heparan sulfate 3-O-sulfotransferase 5; h3-OST-5

# Metabolic_Enzyme_20_Gene_Name:
HS3ST5

# Metabolic_Enzyme_20_Protein_Sequence:
>Heparan sulfate glucosamine 3Osulfotransferase 5
MLFKQQAWLRQKLLVLGSLAVGSLLYLVARVGSLDRLQPICPIEGRLGGARTQAEFPLRA
LQFKRGLLHEFRKGNASKEQVRLHDLVQQLPKAIIIGVRKGGTRALLEMLNLHPAVVKAS
QEIHFFDNDENYGKGIEWYRKKMPFSYPQQITIEKSPAYFITEEVPERIYKMNSSIKLLI
IVREPTTRAISDYTQVLEGKERKNKTYYKFEKLAIDPNTCEVNTKYKAVRTSIYTKHLER
WLKYFPIEQFHVVDGDRLITEPLPELQLVEKFLNLPPRISQYNLYFNATRGFYCLRFNII
FNKCLAGSKGRIHPEVDPSVITKLRKFFHPFNQKFYQITGRTLNWP

# Metabolic_Enzyme_20_Number_of_Residues:
346

# Metabolic_Enzyme_20_Molecular_Weight:
40409

# Metabolic_Enzyme_20_Theoretical_pI:
10.31

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_20_General_Function:
Not Available

# Metabolic_Enzyme_20_Specific_Function:
Rate limiting enzyme for synthesis of HSact. Performs the crucial step modification in the biosynthesis of anticoagulant heparan sulfate (HSact) that is to complete the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA- GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O- sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry

# Metabolic_Enzyme_20_Pathway:
map00532  Chondroitin / Heparan sulfate biosynthesis

# Metabolic_Enzyme_20_Reaction:
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_20_Signals:
1-33

# Metabolic_Enzyme_20_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 2.8.2.23

# Metabolic_Enzyme_20_GenBank_ID_Protein:
23506319

# Metabolic_Enzyme_20_SwissProt_ID:
OST5_HUMAN (Q8IZT8)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
HS3ST5

# Metabolic_Enzyme_20_Geneatlas_id:
HS3ST5

# Metabolic_Enzyme_20_hgnc_id:
HGNC:19419

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Probable)

# Metabolic_Enzyme_20_Gene_Sequence:
>1041 bp
ATGCTATTCAAACAGCAGGCGTGGCTGAGACAGAAGCTCCTGGTGCTGGGAAGCCTTGCC
GTTGGGAGTCTCCTGTATCTAGTCGCCAGAGTTGGGAGCTTGGATAGGCTACAACCCATT
TGCCCCATTGAAGGTCGACTGGGTGGAGCCCGCACTCAGGCTGAATTCCCACTTCGCGCC
CTGCAGTTTAAGCGTGGCCTGCTGCACGAGTTCCGGAAGGGCAACGCTTCCAAGGAGCAG
GTTCGCCTCCATGACCTGGTCCAGCAGCTCCCCAAGGCCATTATCATTGGGGTGAGGAAA
GGAGGCACAAGGGCCCTGCTTGAAATGCTGAACCTACATCCGGCAGTAGTCAAAGCCTCT
CAAGAAATCCACTTTTTTGATAATGATGAGAATTATGGTAAGGGCATTGAGTGGTATAGG
AAAAAGATGCCTTTTTCCTACCCTCAGCAAATCACAATTGAAAAGAGCCCAGCATATTTT
ATCACAGAGGAGGTTCCAGAAAGGATTTACAAAATGAACTCATCCATCAAGTTGTTGATC
ATTGTCAGGGAGCCAACCACAAGAGCTATTTCTGATTATACTCAGGTGCTAGAGGGGAAG
GAGAGGAAGAACAAAACTTATTACAAGTTTGAGAAGCTGGCCATAGACCCTAATACATGC
GAAGTGAACACAAAATACAAAGCAGTAAGAACCAGCATCTACACCAAACATCTGGAAAGG
TGGTTGAAATACTTTCCAATTGAGCAATTTCATGTCGTCGATGGAGATCGCCTCATCACG
GAACCTCTGCCAGAACTTCAGCTCGTGGAGAAGTTCCTAAATCTGCCTCCAAGGATAAGT
CAATACAATTTATACTTCAATGCTACCAGAGGGTTTTACTGCTTGCGGTTTAATATTATC
TTTAATAAGTGCCTGGCGGGCAGCAAGGGGCGCATTCATCCAGAGGTGGACCCCTCTGTC
ATTACTAAATTGCGCAAATTCTTTCATCCTTTTAATCAAAAATTTTACCAGATCACTGGG
AGGACATTGAACTGGCCCTAA

# Metabolic_Enzyme_20_GenBank_ID_Gene:
AF503292

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_20_Locus:
6q22.31

# Metabolic_Enzyme_20_SNPs:
Not Available

# Metabolic_Enzyme_20_General_References:
12138164

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
5521

# Metabolic_Enzyme_21_Name:
Carbohydrate sulfotransferase 12

# Metabolic_Enzyme_21_Synonyms:
Chondroitin 4-O- sulfotransferase 2; Chondroitin 4-sulfotransferase 2; C4ST2; C4ST- 2; Sulfotransferase Hlo

# Metabolic_Enzyme_21_Gene_Name:
CHST12

# Metabolic_Enzyme_21_Protein_Sequence:
>Carbohydrate sulfotransferase 12
MTKARLFRLWLVLGSVFMILLIIVYWDSAGAAHFYLHTSFSRPHTGPPLPTPGPDRDREL
TADSDVDEFLDKFLSAGVKQSDLPRKETEQPPAPGSMEESVRGYDWSPRDARRSPDQGRQ
QAERRSVLRGFCANSSLAFPTKERAFDDIPNSELSHLIVDDRHGAIYCYVPKVACTNWKR
VMIVLSGSLLHRGAPYRDPLRIPREHVHNASAHLTFNKFWRRYGKLSRHLMKVKLKKYTK
FLFVRDPFVRLISAFRSKFELENEEFYRKFAVPMLRLYANHTSLPASAREAFRAGLKVSF
ANFIQYLLDPHTEKLAPFNEHWRQVYRLCHPCQIDYDFVGKLETLDEDAAQLLQLLQVDR
QLRFPPSYRNRTASSWEEDWFAKIPLAWRQQLYKLYEADFVLFGYPKPENLLRD

# Metabolic_Enzyme_21_Number_of_Residues:
414

# Metabolic_Enzyme_21_Molecular_Weight:
48415

# Metabolic_Enzyme_21_Theoretical_pI:
9.69

# Metabolic_Enzyme_21_GO_Classification:
Not Available

# Metabolic_Enzyme_21_General_Function:
Not Available

# Metabolic_Enzyme_21_Specific_Function:
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor

# Metabolic_Enzyme_21_Pathway:
map00532  Chondroitin / Heparan sulfate biosynthesis;
 map00920  Sulfur metabolism

# Metabolic_Enzyme_21_Reaction:
3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF03567:Sulfotransfer_2

# Metabolic_Enzyme_21_Signals:
1-31

# Metabolic_Enzyme_21_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 2.8.2.5

# Metabolic_Enzyme_21_GenBank_ID_Protein:
8925968

# Metabolic_Enzyme_21_SwissProt_ID:
CHSTC_HUMAN (Q9NRB3)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
CHST12

# Metabolic_Enzyme_21_Geneatlas_id:
CHST12

# Metabolic_Enzyme_21_hgnc_id:
HGNC:17423

# Metabolic_Enzyme_21_PDB_ID:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_21_Gene_Sequence:
>1245 bp
ATGACCAAGGCCCGGCTGTTCCGGCTGTGGCTGGTGCTGGGGTCGGTGTTCATGATCCTG
CTGATCATCGTGTACTGGGACAGCGCAAGCGCCGCGCACTTCTACTTGCACACGTCCTTC
TCTAAGCCGCACACAGGGCCGCCGCTGCCCACGCCCGGGCCGGACAGGGACAGGGAGCTC
ACGGCCGACTCCGATGTCGACGAGTTTCTGGACAAGTTTCTCAGTGCTGGCGTGAAGCAG
AGCGACCTTCCCAGAAAGGAGACGGAGCAGCCGCTTGCGCCGGGGAGCATGGAGGAGAGC
GTGAGAGGCTACGACTGGTCCCCGCGCGACGCCCGGCGCAGCCCAGACCAGGGCCGGCAG
CAGGCGGAGCGGAGGAGCGTGCTGCGGGGCTTCTGCGCCAACTCCAGCCTGGCCTTCCCC
ACCAAGGAGCGCGCATTCGACGACATCCCCAACTCGGAGCTGAGCCACCTGATCGTGGAC
GACCGGCACGGGGCCATCTACTGCTACGTGCCCAAGGTGGCCTGCACCAACTGGAAGCGC
GTGATGATCGTGCTGAGCGGAAGCCTGCTGCACCGCGGTGCGCCCTACCGCGACCCGCTG
CGCATCCCGCGCGAGCACGTGCACAACGCCAGCGCGCACCTGACCTTCAACAAGTTCTGG
CGCCGCTACGGGAAGCTCTCCCGCCACCTCATGAAGGTCAAGCTCAAGAAGTACACCAAG
TTCCTCTTCGTGCGCGACCCCTTCGTGCGCCTGATCTCCGCCTTCCGCAGCAAGTTCGAG
CTGGAGAACGAGGAGTTCTACCGCAAGTTCGCCGTGCCCATGCTGCGGCTGTACGCCAAC
CACACAAGCCTGCCCGCCTCGGCGCGCGAGGCCTTCCGCGCTGGCCTCAAGGTGTCCTTC
GCCAACTTCATCCAGTACCTGCTGGACCCGCACACGGAGAAGCTGGCGCCCTTCAACGAG
CACTGGCGGCAGGTGTACCGCCTCTGCCACCCGTGCCAGATCGACTACGACTTCGTGGGG
AAGCTGGAGACTCTGGACGAGGACGCCGCGCAGCTGCTGCAGCTACTCCAGGTGGACCGG
CAGCTCCGCTTCCCCCCGAGCTACCGGAACAGGACCGCCAGCAGCTGGGAGGAGGACTGT
TTCGCCAAGATCCCCCTGGCCTGGAGGCAGCAGCTGTATAAACTCTACGAGGCCGACTTT
GTTCTCTTCGGCTACCCCAAGCCCGAAAACCTCCTCCGAGACTGA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
AF239822

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_21_Locus:
7p22

# Metabolic_Enzyme_21_SNPs:
rs12536223; rs3735099; rs3735100; rs17132395; rs17132399; rs17793768; rs2023968; rs2023969; rs12671804; rs4721695; rs4721707; rs2270005; rs6952809; rs2969073; rs10215904; rs4719530; rs12533091; rs11762300; rs2906182; rs12534223; rs12536888; rs4721698; rs7796798; rs4721697; rs6944568; rs10239877; rs10262626; rs10232546; rs7809879; rs10245377; rs9791681; rs10280923; rs10227362; rs1946119; rs6947585; rs10215412; rs6972852; rs2969077; rs10245183; rs17132393; rs17132405; rs3735102; rs3735101; rs11537796; rs10536150; rs4721696; rs35095035; rs34629622; rs34423807; rs35533837; rs1548593; rs35219818; rs13232882; rs13222608; rs11347484; rs34239120; rs34061454; rs35870806; rs34166896; rs13242740; rs34120517; rs13228768; rs11281917; rs34507265; rs10241898; rs17132381; rs13222526; rs35796313; rs34270821; rs35292770; rs28376914; rs7350030; rs10569839; rs34653289; rs13242736; rs5881922; rs13246806; rs34949759; rs34016433; rs35801461; rs34952308; rs13239866; rs11330967; rs10615727; rs35199658; rs13242753; rs13239996; rs2398632; rs13245729; rs28778015; rs34607760; rs10615726; rs2906181; rs17151773; rs35139598; rs34936735; rs7787073; rs2906180; rs35598568; rs13245636; rs13245643; rs35989845; rs10258154; rs28712717; rs2969076; rs13228771; rs13242378; rs10259587; rs10267898; rs11772554; rs11978738; rs1476614; rs17132410; rs17793630; rs1978169; rs2398633; rs2969078; rs4721709; rs6972497; rs7789095; rs869727; rs872517

# Metabolic_Enzyme_21_General_References:
10781601; 12975309; 12847091

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
5518

# Metabolic_Enzyme_22_Name:
Carbohydrate sulfotransferase 11

# Metabolic_Enzyme_22_Synonyms:
Chondroitin 4-O- sulfotransferase 1; Chondroitin 4-sulfotransferase 1; C4ST; C4ST-1; C4S-1

# Metabolic_Enzyme_22_Gene_Name:
CHST11

# Metabolic_Enzyme_22_Protein_Sequence:
>Carbohydrate sulfotransferase 11
MKPALLEVMRMNRICRMVLATCLGSFILVIFYFQSMLHPVMRRNPFGVDICCRKGSRSPL
QELYNPIQLELSNTAVLHQMRRDQVTDTCRANSATSRKRRVLTPNDLKHLVVDEDHELIY
CYVPKVACTNWKRLMMVLTGRGKYSDPMEIPANEAHVSANLKTLNQYSIPEINHRLKSYM
KFLFVREPFERLVSAYRNKFTQKYNISFHKRYGTKIIKRQRKNATQEALRKGDDVKFEEF
VAYLIDPHTQREEPFNEHWQTVYSLCHPCHIHYDLVGKYETLEEDSNYVLQLAGVGSYLK
FPTYAKSTRTTDEMTTEFFQNISSEHQTQLYEVYKLDFLMFNYSVPSYLKLE

# Metabolic_Enzyme_22_Number_of_Residues:
352

# Metabolic_Enzyme_22_Molecular_Weight:
41555

# Metabolic_Enzyme_22_Theoretical_pI:
9.07

# Metabolic_Enzyme_22_GO_Classification:
Not Available

# Metabolic_Enzyme_22_General_Function:
Not Available

# Metabolic_Enzyme_22_Specific_Function:
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6- di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor

# Metabolic_Enzyme_22_Pathway:
map00532  Chondroitin / Heparan sulfate biosynthesis;
 map00920  Sulfur metabolism

# Metabolic_Enzyme_22_Reaction:
3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF03567:Sulfotransfer_2

# Metabolic_Enzyme_22_Signals:
None

# Metabolic_Enzyme_22_Transmembrane_Regions:
17-37

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 2.8.2.5

# Metabolic_Enzyme_22_GenBank_ID_Protein:
7768662

# Metabolic_Enzyme_22_SwissProt_ID:
CHSTB_HUMAN (Q9NPF2)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
CHST11

# Metabolic_Enzyme_22_Geneatlas_id:
CHST11

# Metabolic_Enzyme_22_hgnc_id:
HGNC:17422

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_22_Gene_Sequence:
>1059 bp
ATGAAGCCAGCGCTGCTGGAAGTGATGAGGATGAACAGAATCTGCCGGATGGTGCTGGCC
ACTTGCTTGGGATCCTTTATCCTGGTCATCTTCTATTTCCAAAGTATGTTGCACCCAGTC
ATGCGGAGGAATCCCTTTGGTGTGGACATCTGCTGCCGGAAGGGGTCCCGAAGCCCCCTG
CAGGAACTCTACAACCCAATCCAGCTGGAGCTCTCAAACACTGCTGTCCTGCACCAGATG
CGGCGGGACCAGGTGACAGACACGTGCCGAGCCAACAGCGCCACAAGCCGTAAGCGGAGG
GTGCTGACCCCCAACGACCTGAAGCACTTGGTGGTGGATGAGGACCACGAGCTCATCTAC
TGCTACGTGCCCAAGGTGGCCTGCACCAACTGGAAGCGGCTCATGATGGTCCTGACCGGG
CGGGGGAAGTACAGCGACCCCATGGAGATCCCGGCCAACGAGGCACACGTCTCCGCCAAC
CTGAAGACCCTGAACCAGTACAGCATCCCAGAAATCAACCACCGCTTGAAAAGCTACATG
AAGTTCCTGTTTGTCCGGGAGCCCTTCGAGAGGCTAGTGTCCGCCTACCGCAACAAGTTC
ACCCAGAAGTACAACATCTCCTTCCACAAGCGGTACGGCACCAAGATCATCAAACGCCAG
CGGAAGAACGCCACCCAGGAGGCCCTGCGCAAAGGGGACGATGTCAAATTCGAGGAGTTT
GTGGCCTATCTCATCGACCCACACACCCAGCGGGAGGAGCCTTTCAACGAACACTGGCAA
ACCGTCTACTCACTCTGCCATCCCTGCCACATCCACTATGACCTCGTGGGCAAGTACGAG
ACACTGGAAGAGGATTCTAATTACGTCCTGCAGCTGGCAGGAGTGGGCAGCTACCTGAAG
TTCCCCACCTATGCAAAGTCTACGAGAACTACTGATGAAATGACCACAGAATTCTTCCAG
AACATCAGCTCAGAGCACCAAACGCAGCTGTACGAAGTCTACAAACTCGATTTTTTAATG
TTCAATTACTCAGTGCCAAGCTACCTGAAATTGGAATAA

# Metabolic_Enzyme_22_GenBank_ID_Gene:
AB042326

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_22_Locus:
12q

# Metabolic_Enzyme_22_SNPs:
rs11112060; rs7976582; rs11611620; rs12315553; rs17041518; rs3751318; rs11614105; rs11612813; rs17035626; rs11615633; rs11112062; rs1922260; rs17035624; rs10778333; rs1704904; rs1704898; rs2559639; rs703660; rs1650137; rs2055861; rs2103391; rs907097; rs1795871; rs1343928; rs1795848; rs835487; rs312164; rs1541794; rs1795867; rs1882497; rs1704911; rs312144; rs1795856; rs2665749; rs2665739; rs2374400; rs1795859; rs1704903; rs1704889; rs879388; rs703681; rs312141; rs1186309; rs835488; rs1795855; rs1704926; rs1622100; rs1863880; rs313320; rs1626422; rs1650141; rs1795849; rs1164766; rs746034; rs1795870; rs835489; rs2665741; rs835479; rs2280685; rs1882493; rs1619845; rs2374410; rs312148; rs1704927; rs1704923; rs2374411; rs167510; rs1795874; rs1650136; rs1704917; rs313327; rs2665742; rs746035; rs835481; rs835484; rs864454; rs312157; rs313316; rs2694418; rs1344677; rs1164760; rs1704894; rs703667; rs312171; rs1882492; rs1795857; rs6539156; rs2468109; rs6419387; rs737113; rs7970787; rs10507181; rs11112069; rs2463439; rs703664; rs3812796; rs11613208; rs1164763; rs10778349; rs7956477; rs7314687; rs7310129; rs7976087; rs10861260; rs10861250; rs7962537; rs835482; rs10861271; rs7297643; rs2029738; rs313323; rs1624481; rs835477; rs7980326; rs10778345; rs2694414; rs7973993; rs703670; rs10861268; rs10861241; rs10507180; rs4964826; rs7300706; rs10861238; rs7309946; rs7312273; rs10778342; rs1704921; rs703680; rs1704878; rs1922265; rs2081807; rs7137559; rs312139; rs11112131; rs4964811; rs7314958; rs11112103; rs1795872; rs10861259; rs4964825; rs10507177; rs7963874; rs313321; rs3751319; rs10861249; rs1626044; rs7485263; rs956886; rs3902812; rs7301678; rs7965164; rs10861244; rs2463441; rs1795851; rs11112160; rs4964821; rs4462423; rs1650129; rs1164857; rs313318; rs1704908; rs11112119; rs10861245; rs313324; rs835226; rs10861263; rs7974091; rs1704922; rs7980528; rs11112143; rs2162661; rs167490; rs1185144; rs10861256; rs6539163; rs7132905; rs2730291; rs1795873; rs7972201; rs1005922; rs2141859; rs7980620; rs7960741; rs4964292; rs703669; rs4964836; rs7313427; rs2141856; rs11112109; rs10861266; rs703672; rs7136717; rs4964829; rs7971806; rs1650128; rs7301359; rs312166; rs903250; rs835495; rs10861243; rs11615042; rs7956015; rs1973589; rs10778343; rs4536299; rs7971034; rs1553840; rs10861242; rs7969218; rs1795850; rs12321261; rs703679; rs7315708; rs10778336; rs10861261; rs10778344; rs12308973; rs7316145; rs1650133; rs2374409; rs7133744; rs7974223; rs1880847; rs7968613; rs3751322; rs6539159; rs10861233; rs10861248; rs4964815; rs2453161; rs10778347; rs10778341; rs4964832; rs1474459; rs11613277; rs10507178; rs1002803; rs11610090; rs2141857; rs2081806; rs11613726; rs17035928; rs17036205; rs11112126; rs703673; rs1795864; rs11112095; rs861346; rs2463443; rs10778335; rs312160; rs12316446; rs11612476; rs1795866; rs1529423; rs10861275; rs12581027; rs2559640; rs10507179; rs12306787; rs12422853; rs10746004; rs7972097; rs11112087; rs12579153; rs1704916; rs17035655; rs11614905; rs1650144; rs1704924; rs10861272; rs3894626; rs11610583; rs11112170; rs312140; rs313315; rs11614814; rs1704887; rs3751321; rs11112167; rs17035996; rs11112149; rs1704925; rs12368888; rs7133318; rs17231251; rs4964835; rs11112088; rs1863879; rs1922261; rs2559635; rs2696004; rs1628116; rs10861246; rs3902813; rs12578959; rs2463019; rs12320801; rs312151; rs6539165; rs1164767; rs1650140; rs2695997; rs875679; rs312137; rs7297636; rs10861226; rs17036283; rs11112174; rs17035798; rs10746001; rs835486; rs1704907; rs2695998; rs7978035; rs1650130; rs2033175; rs312158; rs312161; rs17812685; rs6419388; rs11112146; rs11112093; rs10861229; rs2665748; rs1704897; rs7342363; rs12581471; rs11112125; rs2141858; rs312172; rs11112179; rs2888827; rs1704910; rs11609491; rs6539157; rs2280684; rs1704892; rs1795852; rs4964797; rs7306664; rs856592; rs10161421; rs1529422; rs2694410; rs17229903; rs10778338; rs2463438; rs11112168; rs12581080; rs17036007; rs703661; rs7132459; rs12581769; rs312154; rs11610463; rs2696000; rs2696002; rs10861236; rs10861251; rs1529424; rs7298728; rs312136; rs17035961; rs7137398; rs312162; rs11112136; rs1164751; rs312165; rs2029737; rs6539158; rs312145; rs12582770; rs10861239; rs7314698; rs3751320; rs2141855; rs11608891; rs11611979; rs2114879; rs7961596; rs1882494; rs11112124; rs11112164; rs7976717; rs2374399; rs1795862; rs313319; rs2694406; rs11112173; rs2178666; rs1632143; rs312159; rs2695999; rs1097245; rs313325; rs903248; rs1896563; rs312150; rs17813400; rs2694415; rs835492; rs1704879; rs11112154; rs10746005; rs1704918; rs3924373; rs312142; rs11112066; rs11112118; rs12581753; rs834724; rs11112089; rs1704909; rs6539161; rs17035879; rs835483; rs2081808; rs736751; rs7954880; rs10861237; rs11613724; rs312173; rs10861270; rs10861231; rs11112176; rs12371535; rs7133386; rs1922262; rs312147; rs12321380; rs1533085; rs4964824; rs11112159; rs12581154; rs2694417; rs11112114; rs312146; rs10778346; rs12426228; rs1650139; rs1704895; rs1553836; rs10861257; rs7970489; rs7299085; rs835476; rs1704905; rs1625417; rs2694409; rs10507176; rs12581196; rs12581164; rs835480; rs312163; rs703675; rs1795854; rs12426450; rs835491; rs11112161; rs10861228; rs12581735; rs10861252; rs703666; rs4964831; rs2463444; rs11112123; rs11112158; rs1164858; rs10861273; rs10861253; rs12582864; rs12811509; rs6419389; rs11112120; rs1650142; rs7977468; rs6539164; rs7305698; rs7306538; rs6539162; rs12318001; rs12426757; rs11613629; rs1002804; rs2141861; rs12582801; rs11835991; rs10861220; rs11112155; rs11112083; rs11112144; rs1704890; rs4514507; rs2694413; rs11112094; rs835490; rs2463442; rs1863882; rs1922263; rs182587; rs17035707; rs11836281; rs312167; rs12581832; rs17035786; rs7297412; rs6539155; rs10450734; rs17035908; rs703674; rs11610462; rs10861227; rs1704899; rs1148407; rs903251; rs312138; rs1553838; rs2131806; rs313322; rs1704906; rs7133778; rs17036287; rs11112137; rs10861247; rs7137401; rs10861265; rs1650132; rs703671; rs12579373; rs1704902; rs12319682; rs7954613; rs7298441; rs11608669; rs856595; rs7972130; rs17035997; rs10861254; rs7957854; rs11112122; rs10861274; rs1795860; rs312149; rs17035902; rs11112162; rs1704912; rs17207200; rs1795853; rs12581952; rs1704884; rs12300231; rs12426921; rs703665; rs835485; rs12829137; rs10861264; rs1615960; rs11112180; rs35155077; rs2559644; rs11837750; rs1704893; rs703678; rs11112134; rs312155; rs12316883; rs1810133; rs2696001; rs7304590; rs1164764; rs1650143; rs4964810; rs2036834; rs11112152; rs12306264; rs1650134; rs7301126; rs2463440; rs2706273; rs9705782; rs17035765; rs1704900; rs7133111; rs835493; rs12425079; rs17035669; rs7964355; rs17035914; rs11112163; rs17035880; rs11112121; rs7301450; rs10450755; rs1863881; rs703668; rs1704913; rs10778339; rs2559638; rs11608410; rs17036309; rs12317436; rs1164856; rs12580732; rs7965021; rs4964807; rs12307098; rs1164768; rs12581751; rs11612029; rs17036046; rs2374398; rs312168; rs12315283; rs1097134; rs12313211; rs7299035; rs7304402; rs2888823; rs12298099; rs12424144; rs17035659; rs11613363; rs11112156; rs1650126; rs10861222; rs13377671; rs17035768; rs7488930; rs10778334; rs10861232; rs7979881; rs835227; rs11112153; rs1650135; rs12309132; rs703658; rs12810277; rs17036237; rs703676; rs11112091; rs7313632; rs10861255; rs17035742; rs10746003; rs6539160; rs2694419; rs7133112; rs7315246; rs11112142; rs12228186; rs7305637; rs7302142; rs11112181; rs12307816; rs11838344; rs1613173; rs1704915; rs861345; rs11833657; rs11112172; rs7313629; rs17811302; rs1650131; rs11112157; rs1704886; rs4964294; rs6539166; rs10861258; rs2694420; rs10861221; rs12314344; rs1704896; rs12425961; rs10861225; rs2559643; rs7976781; rs4964804; rs12312652; rs17035643; rs1795861; rs10861267; rs1344675; rs17035653; rs1795868; rs312169; rs2374397; rs11112105; rs2694411; rs7299352; rs7957648; rs312170; rs11834442; rs313326; rs312153; rs11112067; rs17036238; rs2695995; rs11112082; rs1070316; rs17035629; rs1704929; rs10861269; rs7133503; rs2888828; rs2178669; rs4964803; rs12299738; rs7306217; rs11112169; rs1965077; rs12809841; rs11112182; rs35340768; rs10861234; rs2559637; rs11112165; rs7296064; rs1704888; rs11112090; rs10778337; rs7961656; rs11112147; rs7313791; rs7979531; rs12317943; rs17035663; rs865606; rs7964130; rs12300557; rs17035692; rs4964795; rs4964809; rs2694416; rs17035941; rs17035737; rs10861224; rs1553839; rs12300525; rs12322703; rs2559642; rs12305128; rs12300833; rs12371457; rs7955767; rs313317; rs703662; rs12297080; rs12581482; rs12829561; rs1631471; rs7313820; rs1014046; rs1704885; rs17814514; rs11112178; rs7958209; rs12582002; rs12825144; rs12099519; rs2036836; rs7297460; rs10778340; rs10861240; rs1896562; rs1650127; rs2706271; rs17812021; rs12315181; rs1882496; rs11608393; rs4964802; rs7298542; rs11112104; rs17036293; rs3833801; rs1795863; rs700631; rs17035819; rs7139190; rs312152; rs12828809; rs11112148; rs11834042; rs2307824; rs7961056; rs34784608; rs17035985; rs1704901; rs7953577; rs1966076; rs7303821; rs7134631; rs11112133; rs1631306; rs7954025; rs12823926; rs17035647; rs17035740; rs12581376; rs7299187; rs12814959; rs7313930; rs11112112; rs4964828; rs35904073; rs727862; rs11112150; rs7310635; rs10861223; rs7953927; rs1704914; rs17035989; rs834723; rs17815142; rs7314339; rs17811260; rs17035952; rs17035717; rs11112108; rs7133525; rs1541795; rs11612553; rs17035738; rs11112074; rs2559634; rs12581557; rs835478; rs7978063; rs1704928; rs12303610; rs312143; rs12314910; rs11112177; rs7977435; rs865607; rs2695996; rs12306445; rs10861230; rs11112101; rs7971111; rs7977451; rs1795869; rs7958327; rs4964792; rs4964793; rs11112184; rs12581309; rs12426657; rs17035622; rs12311539; rs17036334; rs6539153; rs17041522; rs12824342; rs3087284; rs36140754; rs3812798; rs12580133; rs3812797; rs7967846; rs3812799; rs34506654; rs34211160; rs34072126; rs11315603; rs11112063; rs7489168; rs10636510; rs11112061; rs35438706; rs12814462; rs35239469; rs12308463; rs34993754; rs11112077; rs11112084; rs11112092; rs11112115; rs17036232; rs12810340; rs12810517; rs5800624; rs6144849; rs1880846; rs35065269; rs33983086; rs34386463; rs34816070; rs11112145; rs7954312; rs35260050; rs10702002; rs34475114; rs28649238; rs4964798; rs3850769; rs35078335; rs7134090; rs1182808; rs11287181; rs10628757; rs34741681; rs12827945; rs35676334; rs12319136; rs1344302; rs35347393; rs12816273; rs10602668; rs2003408; rs35265709; rs11112139; rs10735397; rs4497487; rs11436039; rs28646172; rs34258914; rs35525966; rs34702136; rs11347455; rs35334721; rs12816602; rs34528565; rs34229120; rs34437351; rs11428337; rs5800630; rs12366636; rs12322339; rs955167; rs12831683; rs34979854; rs34588223; rs12299778; rs11112130; rs12833320; rs12582786; rs7313830; rs1922266; rs11112151; rs12811699; rs34345378; rs3039119; rs35967270; rs3039126; rs34492942; rs11112111; rs35962706; rs11112100; rs34273289; rs34354414; rs2088020; rs35588722; rs12319184; rs3039184; rs2019700; rs11612934; rs2114878; rs34614529; rs11112073; rs11112135; rs11112098; rs34316929; rs35415539; rs10615559; rs4964817; rs12828719; rs1344676; rs11322121; rs9669206; rs7358786; rs11612858; rs36001648; rs34106545; rs34686417; rs11323775; rs35809577; rs7975248; rs34306827; rs28734031; rs12315656; rs11549735; rs10604627; rs34988616; rs34524947; rs33921315; rs2178667; rs35820500; rs35168430; rs12820999; rs7300191; rs35959978; rs12301935; rs34713964; rs35548330; rs10665951; rs35367679; rs13377795; rs34304844; rs35780548; rs873774; rs11112071; rs1627151; rs10593153; rs11388010; rs35723420; rs35189098; rs12228972; rs35666240; rs34660624; rs34673490; rs12826846; rs7313156; rs34234089; rs1845402; rs4499079; rs11112129; rs3039113; rs34767048; rs35113252; rs36024461; rs5800625; rs35166112; rs34559709; rs35595532; rs6539154; rs4964291; rs35170072; rs7965735; rs907096; rs12298060; rs34662197; rs2694421; rs11112081; rs35334308; rs34607403; rs35798745; rs7297232; rs34736677; rs35615376; rs7307561; rs7962055; rs10708406; rs36113644; rs34340804; rs35135589; rs3833803; rs34967812; rs703677; rs7307713; rs28573865; rs4329751; rs11613954; rs11112068; rs34151199; rs34032913; rs12320787; rs4964800; rs7139418; rs35012452; rs36089929; rs7961396; rs34956195; rs12319185; rs35256981; rs12810550; rs3039180; rs12830896; rs11112085; rs11112099; rs34887222; rs12581139; rs11407024; rs4964801; rs35350812; rs1179031; rs34073419; rs12826801; rs35824468; rs12230941; rs34407607; rs4964796; rs11112141; rs35020847; rs11112076; rs7962538; rs35341460; rs11112110; rs4964837; rs10604363; rs12823049; rs10636834; rs3893257; rs3039217; rs34224505; rs12301789; rs35612027; rs35232396; rs1704877; rs12303997; rs12308052; rs35647694; rs35774803; rs11112072; rs35280061; rs34243873; rs35942583; rs13378048; rs10594720; rs12425395; rs34650391; rs35759218; rs1704919; rs34352601; rs35612022; rs958447; rs10711712; rs1650138; rs34685694; rs12309301; rs7953435; rs12814486; rs5800629; rs11304826; rs10665950; rs10695049; rs11112132; rs35837910; rs11294627; rs10528178; rs35487337; rs35686536; rs7305710; rs11829413; rs12308279; rs7302553; rs35252158; rs34845532; rs35732575; rs7133941; rs34142330; rs12303207; rs7967077; rs35074703; rs7298251; rs36092875; rs3039124; rs12311871; rs35313181; rs12810362; rs28450498; rs12819044; rs12317122; rs12370944; rs34581324; rs3039215; rs10602298; rs35796652; rs35505187; rs12369305; rs5800622; rs3833802; rs34725367; rs12810434; rs3039207; rs35274615; rs7302650; rs7955026; rs11112128; rs11310637; rs11285665; rs12812900; rs34726014; rs34913627; rs2665740; rs7964746; rs1704891; rs12369939; rs12313521; rs11112075; rs7133216; rs7314130; rs35833160; rs7132779; rs9630289; rs35695029; rs12319138; rs35511738; rs6144848; rs35106897; rs35902253; rs3039120; rs35193902; rs36019028; rs11112171; rs36101250; rs35526507; rs34760349; rs12314189; rs35499362; rs2178665; rs12814148; rs12313995; rs34101072; rs34306843; rs10622882; rs34633763; rs34215865; rs36156744; rs11112138; rs34605488; rs35142962; rs11612429; rs12813111; rs12367118; rs4427630; rs35764566; rs35601896; rs35122771; rs35225993; rs7961967; rs34536312; rs35626463; rs33972613; rs703659; rs34911522; rs11292565; rs34181493; rs4015333; rs11112078; rs5800626; rs35379294; rs10655174; rs35166043; rs11112086; rs12827404; rs34192004; rs11442051; rs11423793; rs11431861; rs7307796; rs34784870; rs12317847; rs34016841; rs35504512; rs34475451; rs12307498; rs12306794; rs34068945; rs34004149; rs35708488; rs7975558; rs7131930; rs34932602; rs2694412; rs10659007; rs34815132; rs11609580; rs11407023; rs35297995; rs12230666; rs11112117; rs35348357; rs4309231; rs10617603; rs5800627; rs11333586; rs11112065; rs34215694; rs7300417; rs10570106; rs13377941; rs35839555; rs35376549; rs35586447; rs35557487; rs1704920; rs12821938; rs34025402; rs35265165; rs6144846; rs10678406; rs12099958; rs11112116; rs35914834; rs12320316; rs12809215; rs703663; rs35408535; rs1619105; rs7135581; rs11829128; rs7314471; rs1795865; rs4964799; rs2081809; rs10619025; rs34639781; rs35173314; rs11613930; rs34588723; rs11112127; rs11112166; rs34006016; rs11423331; rs2374402; rs11305926; rs4964293; rs11609321; rs35050629; rs1704880; rs12230274; rs2888822; rs2178664; rs1494100; rs3039118; rs7315089; rs35414528; rs2696003; rs34795755; rs34474898; rs28629798; rs4964816; rs2694408; rs11112070; rs1164769; rs35285718; rs34318061; rs12303205; rs12303139; rs3039121; rs7133631; rs11112080; rs2091769; rs11379425; rs2559641; rs35966960; rs34335293; rs7309168; rs7133483; rs12230909; rs11112113; rs4964822; rs7963826; rs4015334; rs35016881; rs11285009; rs34973915; rs11112107; rs12828729; rs192859; rs36121598; rs10690031; rs34902114; rs12818283; rs35398912; rs35791423; rs11279590; rs12309853; rs6144847; rs34226022; rs35586933; rs11829121; rs36114922; rs11452358; rs35359633; rs7305692; rs12371467; rs5800623; rs35047772; rs10533682; rs34651142; rs35674976; rs34869995; rs12814169; rs3039210; rs34140723; rs34451395; rs34709775; rs11830626; rs5800631; rs7305596; rs1038968; rs1048662; rs10778332; rs10778350; rs11112058; rs11112059; rs12305866; rs12306097; rs12306106; rs12307007; rs12318058; rs12321404; rs12367738; rs12810690; rs12828253; rs12829575; rs12829596; rs13377804; rs1565814; rs1565815; rs17035610; rs17036338; rs17036358; rs17828033; rs2141248; rs2172655; rs2178084; rs2254692; rs2254695; rs2254711; rs2254717; rs2254815; rs2254827; rs2255083; rs2374354; rs2374356; rs2453155; rs2453157; rs2463018; rs2463437; rs2468110; rs2642109; rs312156; rs3782418; rs4964290; rs4964791; rs7301525; rs7302213; rs7488439; rs7847; rs7958885; rs7962249; rs7965484; rs7965864; rs7972699; rs7975036; rs7978254; rs903247

# Metabolic_Enzyme_22_General_References:
10781601; 12847091

# Metabolic_Enzyme_22_References:
Not Available

# Metabolic_Enzyme_23_ID:
5575

# Metabolic_Enzyme_23_Name:
Heparan sulfate glucosamine 3-O-sulfotransferase 3B1

# Metabolic_Enzyme_23_Synonyms:
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1; Heparan sulfate 3-O-sulfotransferase 3B1; h3-OST-3B

# Metabolic_Enzyme_23_Gene_Name:
HS3ST3B1

# Metabolic_Enzyme_23_Protein_Sequence:
>Heparan sulfate glucosamine 3Osulfotransferase 3B1
MGQRLSGGRSCLDVPGRLLPQPPPPPPPVRRKLALLFAMLCVWLYMFLYSCAGSCAAAPG
LLLLGSGSRAAHDPPALATAPDGTPPRLPFRAPPATPLASGKEMAEGAASPEEQSPEVPD
SPSPISSFFSGSGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYDKG
LAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIVVVRDPVTRAISDYTQ
TLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLRHFPIRQMLFVSGERL
ISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSRPHCLGKTKGRTHPEI
DREVVRRLREFYRPFNLKFYQMTGHDFGWD

# Metabolic_Enzyme_23_Number_of_Residues:
390

# Metabolic_Enzyme_23_Molecular_Weight:
43325

# Metabolic_Enzyme_23_Theoretical_pI:
10.14

# Metabolic_Enzyme_23_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_23_General_Function:
Not Available

# Metabolic_Enzyme_23_Specific_Function:
Transfers a sulfuryl group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate

# Metabolic_Enzyme_23_Pathway:
Not Available

# Metabolic_Enzyme_23_Reaction:
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_23_Signals:
None

# Metabolic_Enzyme_23_Transmembrane_Regions:
33-53

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 2.8.2.30

# Metabolic_Enzyme_23_GenBank_ID_Protein:
4835725

# Metabolic_Enzyme_23_SwissProt_ID:
OST3B_HUMAN (Q9Y662)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
HS3ST3B1

# Metabolic_Enzyme_23_Geneatlas_id:
HS3ST3B1

# Metabolic_Enzyme_23_hgnc_id:
HGNC:5198

# Metabolic_Enzyme_23_PDB_ID:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Probable)

# Metabolic_Enzyme_23_Gene_Sequence:
>1173 bp
ATGGGGCAGCGCCTGAGTGGCGGCAGATCTTGCCTCGATGTCCCCGGCCGGCTCCTACCG
CAGCCGCCGCCGCCCCCGCCGCCGGTGAGGAGGAAGCTCGCGCTGCTCTTCGCCATGCTC
TGCGTCTGGCTCTATATGTTCCTGTACTCGTGCGCCGGCTCCTGCGCCGCCGCGCCGGGG
CTGCTGCTCCTGGGCTCTGGGTCCCGCGCCGCACACGACCCGCCAGCCCTGGCCACAGCT
CCGGACGGGACGCCCCCCAGGCTGCCGTTCCGGGCGCCGCCAGCCACCCCACTGGCTTCA
GGCAAGGAGATGGCCGAGGGCGCTGCGAGCCCGGAGGAGCAGAGTCCCGAGGTGCCGGAC
TCCCCAAGCCCCATCTCCAGCTTTTTCAGTGGGTCTGGGAGCAAGCAGCTGCCGCAGGCC
ATCATCATCGGCGTGAAGAAGGGCGGCACGCGGGCGCTGCTGGAGTTTCTGCGCGTGCAC
CCCGACGTGCGCGCCGTGGGCGCCGAGCCCCATTTCTTCGATCGCAGCTACGACAAGGGC
CTCGCTTGGTACCGGGACCTGATGCCCAGAACCCTGGACGGGCAGATCACCATGGAGAAG
ACGCCCAGTTACTTCGTCACGCGGGAGGCCCCCGCGCGCATCTCGGCCATGTCCAAGGAC
ACCAAGCTCATCGTGGTGGTGCGGGACCCGGTGACCAGGGCCATCTCGGACTACACGCAG
ACGCTGTCCAAGCGGCCCGACATCCCCACCTTCGAGAGCTTGACGTTCAAAAACAGGACA
GCGGGCCTCATCGACACGTCGTGGAGCGCCATCCAGATCGGCATCTACGCCAAGCACCTG
GAGCACTGGCTGCGCCACTTCCCCATCCGCCAGATGCTCTTCGTGAGCGGCGAGCGGCTC
ATCAGCGACCCGGCCGGGGAGCTGGGCCGCGTGCAAGACTTCCTGGGCCTCAAGAGGATC
ATCACGGACAAGCACTTCTACTTCAACAAGACCAAGGGCTTCCCCTGCCTGAAGAAGGCG
GAGGGCAGCAGCCGGCCCCATTGCCTGGGCAAGACCAAGGGCAGGACCCATCCTGAGATC
GACCGCGAGGTGGTGCGCAGGCTGCGCGAGTTCTACCGGCCTTTCAACCTCAAGTTCTAC
CAGATGACCGGGCACGACTTTGGCTGGGATTGA

# Metabolic_Enzyme_23_GenBank_ID_Gene:
AF105377

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_23_Locus:
17p12-p11.2

# Metabolic_Enzyme_23_SNPs:
rs9906855; rs3785655; rs758049; rs1005322; rs8080590; rs4791574; rs886863; rs9891555; rs2058044; rs1015663; rs11078240; rs719470; rs2108461; rs1990203; rs4791571; rs12453663; rs740378; rs886862; rs2016418; rs2005768; rs9303102; rs11649737; rs9891833; rs7207809; rs9900779; rs1052686; rs1006105; rs12453939; rs740379; rs1005321; rs3785658; rs2323175; rs1317120; rs11078239; rs9908363; rs4792471; rs4792467; rs2001166; rs7216506; rs7216174; rs7222663; rs758051; rs9890916; rs758050; rs2190625; rs740381; rs726942; rs4791573; rs7211702; rs11652661; rs9896731; rs9906089; rs9907589; rs11870395; rs2015155; rs11868276; rs4792473; rs9893855; rs720873; rs7220418; rs740376; rs4791572; rs34375869; rs740380; rs758048; rs9890648; rs16949371; rs4792468; rs12453366; rs2005767; rs886864; rs16949387; rs7222344; rs740377; rs12449373; rs9890382; rs6502345; rs7221273; rs3826365; rs4791575; rs9909862; rs7220003; rs7222205; rs9894280; rs2006828; rs9893188; rs16949359; rs1317121; rs11870163; rs2190626; rs8078587; rs2072243; rs9906590; rs8068213; rs34065582; rs28496104; rs35615961; rs35942275; rs7219199; rs3837820; rs4792469; rs9905840; rs9890556; rs12604080; rs34337918; rs9915747; rs9890474; rs34733087; rs34306851; rs8072689; rs12373159; rs11416873; rs35154149; rs9889431; rs8079900; rs35417747; rs34304103; rs11462805; rs34373896; rs36023180; rs12103925; rs35433351; rs3837819; rs7210862; rs35890607; rs35261316; rs28441393; rs1990202; rs9902190; rs10606329; rs11384759; rs10624325; rs9898199; rs9904622; rs35917592; rs11870724; rs35414783; rs9915168; rs10685004; rs10657077; rs3837818; rs35416270; rs867156; rs35539884; rs34706102; rs7210483; rs3833124; rs12150152; rs9907572; rs7501808; rs12449370; rs5819471; rs2323174; rs12937361; rs9904614; rs12935987; rs5819469; rs9899451; rs35303622; rs11444106; rs9906666; rs7223327; rs35185564; rs2108462; rs12601098; rs34425193; rs34973393; rs34431760; rs34500274; rs35997063; rs35826718; rs9914187; rs5819470; rs12602296; rs35994506; rs35455107; rs9899417; rs9905563; rs12936390; rs34740501; rs12952906; rs5819468; rs4792472; rs9905919; rs28716100; rs8073293; rs11383288; rs7503209; rs7219643; rs35465791; rs11289762; rs34714210; rs9905829; rs35347157; rs35109021; rs33928059; rs11430804; rs4792470; rs2072242; rs3760308; rs10696708; rs10668018; rs3760309; rs34149495; rs11428899; rs1053326; rs10852821; rs11078241; rs11552190; rs11870520; rs12150274; rs12942020; rs12946032; rs1859906; rs1871784; rs2086515; rs2086516; rs2127998; rs2199998; rs2199999; rs2200000; rs2291208; rs3760310; rs6502346; rs7217818; rs7222164; rs7223714; rs7225272; rs7226075; rs733769; rs740382; rs755730; rs755732; rs917310

# Metabolic_Enzyme_23_General_References:
9988767; 10520990; 9988768

# Metabolic_Enzyme_23_References:
Not Available

# Metabolic_Enzyme_24_ID:
5591

# Metabolic_Enzyme_24_Name:
Sulfotransferase family cytosolic 2B member 1

# Metabolic_Enzyme_24_Synonyms:
Sulfotransferase 2B1; Alcohol sulfotransferase; Hydroxysteroid sulfotransferase 2

# Metabolic_Enzyme_24_Gene_Name:
SULT2B1

# Metabolic_Enzyme_24_Protein_Sequence:
>Sulfotransferase family cytosolic 2B member 1
MDGPAEPQIPGLWDTYEDDISEISQKLPGEYFRYKGVPFPVGLYSLESISLAENTQDVRD
DDIFIITYPK
SGTTWMIEIICLILKEGDPSWIRSVPIWERAPWCETIVGAFSLPDQYSP
RLMSSHLPIQIFTKAFFSSKA
KVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLRD
FLKGEVQFGSWFDHIKGWLRMKGKDNFLFITY
EELQQDLQGSVERICGFLGRPLGKEAL
GSVVAHSTFSAMKANTMSNYTLLPPSLLDHRRGAFLRKGVCGD
WKNHFTVAQSEAFDRA
YRKQMRGMPTFPWDEDPEEDGSPDPEPSPEPEPKPSLEPNTSLEREPRPNSSPS
PSPGQ
ASETPHPRPS

# Metabolic_Enzyme_24_Number_of_Residues:
365

# Metabolic_Enzyme_24_Molecular_Weight:
41308

# Metabolic_Enzyme_24_Theoretical_pI:
5.05

# Metabolic_Enzyme_24_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_24_General_Function:
Not Available

# Metabolic_Enzyme_24_Specific_Function:
Catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol

# Metabolic_Enzyme_24_Pathway:
map00150  Androgen and estrogen metabolism;
 map00920  Sulfur metabolism

# Metabolic_Enzyme_24_Reaction:
3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate

# Metabolic_Enzyme_24_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_24_Signals:
None

# Metabolic_Enzyme_24_Transmembrane_Regions:
None

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 2.8.2.2

# Metabolic_Enzyme_24_GenBank_ID_Protein:
1923291

# Metabolic_Enzyme_24_SwissProt_ID:
ST2B1_HUMAN (O00204)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
SULT2B1

# Metabolic_Enzyme_24_Geneatlas_id:
SULT2B1

# Metabolic_Enzyme_24_hgnc_id:
HGNC:11459

# Metabolic_Enzyme_24_PDB_ID:
1Q1Q

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_24_Gene_Sequence:
>1053 bp

ATGGCGTCTCCCCCACCTTTCCACAGCCAGAAGTTGCCAGGTGAATACTTCCGGTACAA
GGGCGTCCCCT
TCCCCGTCGGCCTGTACTCGCTCGAGAGCATCAGCTTGGCGGAGAACA
CCCAAGATGTGCGGGACGACGA
CATCTTTATCATCACCTACCCCAAGTCAGGCACGACC
TGGATGATCGAGATCATCTGCTTAATCCTGAAG
GAAGGGGATCCATCCTGGATCCGCTC
CGTGCCCATCTGGGAGCGGGCACCCTGGTGTGAGACCATTGTGG
GTGCTTTCAGCCTCC
CGGACCAGTACAGCCCCCGCCTCATGAGCTCCCATCTTCCCATCCAGATCTTCAC
CAAG
GCCTTCTTCAGCTCCAAGGCCAAGGTGATCTACATGGGCCGCAACCCCCGGGACGTTGTG
GTCTCC
CTCTATCATTACTCCAAGATCGCCGGGCAGTTAAAGGACCCGGGCACACCCGA
CCAGTTCCTGAGGGACT
TCCTCAAAGGCGAAGTGCAGTTTGGCTCCTGGTTCGACCACA
TTAAGGGCTGGCTTCGGATGAAGGGCAA
AGACAACTTCCTATTTATCACCTACGAGGAG
CTGCAGCAGGACTTACAGGGCTCCGTGGAGCGCATCTGT
GGGTTCCTGGGCCGTCCGCT
GGGCAAGGAGGCACTGGGCTCCGTCGTGGCACACTCAACCTTCAGCGCCA
TGAAGGCCA
ACACCATGTCCAACTACACGCTGCTGCCTCCCAGCCTGCTGGACCACCGTCGCGGGGCCT
T
CCTCCGGAAAGGGGTCTGCGGCGACTGGAAGAACCACTTCACGGTGGCCCAGAGCGAA
GCCTTCGATCGT
GCCTACCGCAAGCAGATGCGGGGGATGCCGACCTTCCCCTGGGATGA
AGACCCGGAGGAGGATGGCAGCC
CAGATCCTGAGCCCAGCCCTGAGCCTGAGCCCAAGC
CCAGCCTTGAGCCCAACACCAGCCTGGAGCGTGA
GCCCAGACCCAACTCCAGCCCCAAC
CCCAGCCCCGGCCAGGCCTCTGAGACCCCGCACCCACGACCCTCA
TAA

# Metabolic_Enzyme_24_GenBank_ID_Gene:
U92314

# Metabolic_Enzyme_24_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_24_Locus:
19q13.3

# Metabolic_Enzyme_24_SNPs:
rs2302947; rs2544794; rs1132054; rs2302948; rs1052131; rs2431141; rs3815691; rs12460535; rs4149455; rs2544789; rs10416980; rs3760802; rs3760800; rs8109054; rs2544788; rs10424976; rs8109050; rs4802489; rs11083943; rs2544785; rs6509396; rs2544784; rs10426377; rs175924; rs2544783; rs8108904; rs3745726; rs3848542; rs12611137; rs2544787; rs4802495; rs11672175; rs4801764; rs11880293; rs4080470; rs10417472; rs10401347; rs8108022; rs11880831; rs4149456; rs10425691; rs2665601; rs11882923; rs11083944; rs10420140; rs12462337; rs2544786; rs6509393; rs2665605; rs11881295; rs7248376; rs10426193; rs2544800; rs6509397; rs10425172; rs7249780; rs3760808; rs4801766; rs10420172; rs10424445; rs2665586; rs10418193; rs2665580; rs4080469; rs3760804; rs12611168; rs10424655; rs4802490; rs8109679; rs12462087; rs8106759; rs2665583; rs9304677; rs7249118; rs3909296; rs6509392; rs3826827; rs10424237; rs4802491; rs10418222; rs12981320; rs12608902; rs2665606; rs8111787; rs11878385; rs11880848; rs6509394; rs2665584; rs12976976; rs7409348; rs2379081; rs2544793; rs3760805; rs7408540; rs12611151; rs4801768; rs2665582; rs34373168; rs8112135; rs6509391; rs12611128; rs12610737; rs11882607; rs11083946; rs2665577; rs10426563; rs3786749; rs7248627; rs2665587; rs3786750; rs2665581; rs10415318; rs12611192; rs4801765; rs9676424; rs3909295; rs10404801; rs11882405; rs2302949; rs11083945; rs2544795; rs9676516; rs12977025; rs7258739; rs12975397; rs10426628; rs2544790; rs2379085; rs7246557; rs7255533; rs9973264; rs11666506; rs13347093; rs2665600; rs2544804; rs10422117; rs8107786; rs2246836; rs10419482; rs9676485; rs12460513; rs8108917; rs8108812; rs7257121; rs2665604; rs12981299; rs12981760; rs10403171; rs10420304; rs2665579; rs10422717; rs12608918; rs8107219; rs11878647; rs2665575; rs12977008; rs12611181; rs8100256; rs3815692; rs8103525; rs6509395; rs11083942; rs10416165; rs11672291; rs279447; rs2246837; rs3859437; rs2665603; rs11671705; rs2665574; rs10420892; rs2665602; rs12611119; rs2544801; rs11882293; rs10416119; rs8113355; rs10410524; rs12609189; rs279449; rs11878685; rs1052124; rs5828356; rs11286832; rs2544799; rs34578466; rs10589655; rs11083941; rs2544802; rs34808712; rs35790289; rs2544792; rs10648968; rs34429366; rs10427068; rs34768198; rs279446; rs12980918; rs28626601; rs9676509; rs10407019; rs34332722; rs2665576; rs34698909; rs35448535; rs10577756; rs11878722; rs8104499; rs36003772; rs2544782; rs34741298; rs3837954; rs10411546; rs34625801; rs2544796; rs3859438; rs2941502; rs2544798; rs9676465; rs7259869; rs2544803; rs10421116; rs34399820; rs35503043; rs9789258; rs10411304; rs2665596; rs11285675; rs35536990; rs10581692; rs11881377; rs9789261; rs4802492; rs8108788; rs2544791; rs2544781; rs34482710; rs35921662; rs2379089; rs35197699; rs2379082; rs34353616; rs8109498; rs9676529; rs28446557; rs4011542; rs12983435; rs11666287; rs35450632; rs10417160; rs7259862; rs13343592; rs35211958; rs2665597; rs11671834; rs279445; rs10423750; rs34345412; rs35813972; rs10402100; rs3760806; rs3833253; rs10426286; rs12974007; rs3760801; rs28411253; rs35375190; rs34154386; rs35544342; rs34107488; rs2665578; rs12104307; rs2665599; rs10408348; rs35172026; rs10668221; rs35747850; rs34522310; rs7256244; rs35749262; rs10424430; rs34520151; rs12981151; rs36088037; rs35221052; rs5828354; rs34704123; rs35905762; rs2665590; rs28439983; rs2665585; rs3843745; rs34512399; rs12976785; rs2665608; rs10425879; rs28370904; rs11879142; rs4801767; rs34945864; rs10407495; rs3760807; rs2379083; rs12979357; rs11882313; rs2544797; rs11668970; rs36014830; rs5828355; rs3893696; rs11453549; rs2890071; rs34812578; rs28366580; rs2665598; rs12979991; rs10552230; rs35186872; rs10549281; rs10405920; rs2665607; rs34974937; rs34230215; rs10427087; rs34886384; rs3760803; rs35280795; rs11880900; rs2379084; rs35679165; rs34813342; rs10415492; rs35078110; rs28759208; rs8108153; rs2665588; rs12980615; rs3837955; rs34622126; rs10639250; rs279448; rs10415861; rs279450; rs10413911; rs1236093; rs12460223; rs12611321; rs12981419; rs16982137; rs16982149; rs16982159; rs17842463; rs2544808; rs2617805; rs2665591; rs2665593; rs279451; rs279452; rs34439264; rs3745727; rs378333; rs402209; rs411482; rs9807810

# Metabolic_Enzyme_24_General_References:
9799594; 12145317; 12923182

# Metabolic_Enzyme_24_References:
Not Available

# Metabolic_Enzyme_25_ID:
8643

# Metabolic_Enzyme_25_Name:
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

# Metabolic_Enzyme_25_Synonyms:
Glucosaminyl N-deacetylase/N-sulfotransferase 4; NDST- 4; N-heparan sulfate sulfotransferase 4; N-HSST 4[Includes: Heparan sulfate N-deacetylase 4

# Metabolic_Enzyme_25_Gene_Name:
NDST4

# Metabolic_Enzyme_25_Protein_Sequence:
>Bifunctional heparan sulfate Ndeacetylase/Nsulfotransferase 4
MNLIVKLRRSFRTLIVLLATFCLVSIVISAYFLYSGYKQEMTLIETTAEAECTDIKILPY
RSMELKTVKPIDTSKTDPTVLLFVESQYSQLGQDIIAILESSRFQYHMVIAPGKGDIPPL
TDNGKGKYTLVIYENILKYVSMDSWNRELLEKYCVEYSVSIIGFHKANENSLPSTQLKGF
PLNLFNNLALKDCFVNPQSPLLHITKAPKVEKGPLPGEDWTIFQYNHSTYQPVLLTELQT
EKSLSSLSSKTLFATVIQDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLSL
DRYILVDIDDIFVGKEGTRMNVKDVKALLETQNLLRTQVANFTFNLGFSGKFYHTGTEEE
DEGDDLLLRSVDEFWWFPHMWSHMQPHLFHNESSLVEQMILNKEFALEHGIPINMGYAVA
PHHSGVYPVHIQLYAAWKKVWGIQVTSTEEYPHLKPARYRKGFIHNSIMVLPRQTCGLFT
HTIFYKEYPGGPQELDKSIRGGELFLTILLNPISIFMTHLSNYGNDRLGLYTFVNLVNFV
QSWTNLKLQTLPPVQLAHQYFELFPEQKDPLWQNPCDDKRHKDIWSREKTCDHLPKFLVI
GPQKTGTTALYLFLLMHPSIISNLPSPKTFEEVQFFNGNNYHKGIDWYMDFFPTPSNTTS
DFLFEKSANYFHSEEAPRRAASLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALRFNF
YEVISTGHWAPSDLKTLQRRCLVPGWYAVHIERWLTYFATSQLLIIDGQQLRSDPATVMD
EVQKFLGVTPRYNYSEALTFDPQKGFWCQLLEGGKTKCLGKSKGRKYPPMDPESRTFLSN
YYRDHNVELSKLLHRLGQPLPSWLRQELQKVR

# Metabolic_Enzyme_25_Number_of_Residues:
872

# Metabolic_Enzyme_25_Molecular_Weight:
100717

# Metabolic_Enzyme_25_Theoretical_pI:
7.59

# Metabolic_Enzyme_25_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_25_General_Function:
Not Available

# Metabolic_Enzyme_25_Specific_Function:
Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity

# Metabolic_Enzyme_25_Pathway:
Not Available

# Metabolic_Enzyme_25_Reaction:
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine

# Metabolic_Enzyme_25_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_25_Signals:
1-29

# Metabolic_Enzyme_25_Transmembrane_Regions:
14-34

# Metabolic_Enzyme_25_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_25_EC_Link:
EC 2.8.2.8

# Metabolic_Enzyme_25_GenBank_ID_Protein:
11414892

# Metabolic_Enzyme_25_SwissProt_ID:
NDST4_HUMAN (Q9H3R1)

# Metabolic_Enzyme_25_swissprot_Name:
Not Available

# Metabolic_Enzyme_25_Genecard_id:
NDST4

# Metabolic_Enzyme_25_Geneatlas_id:
NDST4

# Metabolic_Enzyme_25_hgnc_id:
HGNC:20779

# Metabolic_Enzyme_25_PDB_ID:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_25_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_25_Gene_Sequence:
>2619 bp
ATGAATCTTATTGTGAAACTTCGGAGAAGTTTTCGAACATTGATTGTTCTCTTAGCTACC
TTTTGCTTGGTGAGCATTGTCATTTCTGCCTATTTTCTCTACTCTGGCTACAAACAGGAA
ATGACACTTATTGAAACCACTGCAGAAGCAGAATGCACTGACATCAAAATTCTACCATAT
AGGTCAATGGAGCTGAAAACAGTTAAACCTATTGACACATCCAAAACGGACCCTACTGTC
CTTCTCTTCGTGGAGAGCCAATACTCTCAACTCGGTCAAGATATCATAGCTATTTTGGAG
TCCAGCCGATTTCAGTACCACATGGTTATTGCCCCTGGAAAGGGAGATATACCTCCTCTT
ACAGATAATGGCAAAGGGAAATATACTTTAGTTATTTATGAAAATATTCTGAAGTATGTC
AGCATGGACTCATGGAATCGAGAGCTTTTAGAAAAATACTGTGTGGAATACAGTGTTAGT
ATAATCGGTTTTCATAAAGCCAATGAGAACAGCTTACCAAGTACACAATTAAAAGGCTTT
CCGTTAAACCTTTTCAATAATCTAGCTCTAAAGGACTGTTTTGTTAACCCTCAATCTCCT
TTGCTGCATATTACCAAAGCCCCCAAGGTTGAGAAAGGCCCTCTTCCTGGGGAAGACTGG
ACTATTTTCCAATATAATCATTCAACCTACCAGCCTGTACTTTTAACTGAGTTACAGACA
GAAAAATCCCTGTCATCCTTGTCTAGCAAAACACTCTTTGCAACGGTGATTCAGGATCTG
GGGCTTCATGATGGAATTCAGAGAGTACTTTTTGGCAACAACTTGAACTTTTGGCTGCAC
AAGCTCATCTTCATAGATGCCATCTCCTTCTTGTCAGGGAAGAGGCTGACATTGTCCTTG
GACAGGTACATCCTTGTGGACATTGATGATATATTTGTTGGGAAAGAGGGAACAAGGATG
AATGTCAAAGATGTGAAGGCATTACTAGAGACTCAAAATTTACTGCGCACTCAGGTTGCA
AATTTTACCTTCAACCTTGGATTTTCAGGGAAGTTTTACCACACAGGGACTGAAGAGGAA
GATGAAGGAGATGACCTTTTACTTCGGTCTGTGGATGAGTTCTGGTGGTTTCCTCACATG
TGGAGCCACATGCAGCCCCACCTCTTCCACAACGAGTCATCTTTAGTAGAGCAGATGATT
CTCAACAAGGAATTTGCACTGGAACATGGAATACCAATCAACATGGGCTATGCTGTGGCC
CCACATCACTCAGGGGTCTACCCGGTTCACATTCAGCTGTATGCAGCTTGGAAGAAGGTC
TGGGGTATTCAAGTCACCAGCACTGAAGAATATCCACATCTGAAACCTGCCCGGTACAGA
AAGGGCTTCATTCACAATAGCATCATGGTCCTCCCTCGACAGACTTGTGGGTTGTTCACT
CACACTATTTTCTACAAAGAATATCCAGGAGGACCCCAAGAACTGGATAAAAGTATCAGA
GGAGGTGAACTTTTTCTCACAATCCTTCTAAACCCAATCAGCATTTTCATGACCCATTTA
TCAAACTATGGAAATGACCGCCTAGGGTTATATACCTTTGTGAACTTGGTCAACTTTGTG
CAGAGCTGGACCAACCTGAAATTGCAAACTCTGCCTCCAGTGCAACTGGCCCACCAGTAT
TTTGAGCTCTTCCCTGAGCAGAAAGACCCTCTATGGCAGAATCCATGTGATGATAAACGA
CACAAAGACATCTGGTCCAGAGAGAAAACTTGTGACCACTTACCAAAATTTCTAGTAATT
GGTCCACAAAAAACAGGAACAACTGCACTTTATTTATTTCTTCTTATGCATCCTTCAATC
ATCAGCAATCTCCCTAGTCCAAAGACATTTGAGGAAGTTCAGTTCTTTAATGGCAACAAC
TATCACAAAGGAATAGACTGGTATATGGACTTTTTCCCTACACCATCCAATACTACAAGT
GACTTTCTGTTTGAAAAGAGTGCTAATTACTTCCATTCGGAAGAAGCTCCAAGACGAGCC
GCATCTCTTGTCCCCAAAGCCAAGATCATCACCATCCTCATTGACCCCTCAGACAGGGCA
TACTCTTGGTACCAGCACCAACGATCACATGAAGATCCAGCTGCTCTGAGGTTCAATTTC
TATGAAGTTATTTCAACAGGACATTGGGCTCCATCTGACTTAAAAACTTTGCAGAGAAGA
TGCCTAGTACCTGGATGGTATGCAGTCCACATAGAAAGATGGCTAACTTACTTTGCTACT
TCTCAGTTGCTAATTATTGATGGACAGCAGCTGAGATCTGACCCAGCTACTGTGATGGAT
GAAGTCCAGAAGTTTCTGGGAGTTACACCTCGTTATAATTACTCTGAAGCACTAACGTTT
GATCCCCAAAAGGGTTTTTGGTGTCAATTACTGGAAGGAGGAAAGACAAAATGCCTTGGA
AAAAGCAAAGGCCGAAAATATCCACCTATGGATCCAGAGTCTAGAACGTTCCTCTCTAAT
TACTACCGAGATCATAATGTGGAACTATCCAAACTGCTACACAGACTGGGACAGCCTCTG
CCATCGTGGCTGAGACAGGAACTGCAGAAAGTGAGATAG

# Metabolic_Enzyme_25_GenBank_ID_Gene:
AB036429

# Metabolic_Enzyme_25_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_25_Locus:
4q25-q26

# Metabolic_Enzyme_25_SNPs:
rs6843860; rs35449662; rs475441; rs2127460; rs562049; rs528282; rs473989; rs1382999; rs511497; rs551248; rs509777; rs532923; rs578131; rs563820; rs3114034; rs477208; rs7679114; rs493304; rs1479796; rs512355; rs1893120; rs505154; rs496992; rs510657; rs1824954; rs7667960; rs503256; rs530974; rs569105; rs521110; rs550608; rs483240; rs474314; rs569917; rs479087; rs581288; rs566198; rs484404; rs481915; rs512349; rs525972; rs529078; rs6533832; rs511198; rs504346; rs505277; rs480693; rs554772; rs13105185; rs486186; rs476739; rs486441; rs9996306; rs13104877; rs481751; rs514133; rs493237; rs528793; rs532137; rs477076; rs567227; rs17584636; rs11938603; rs6533834; rs558717; rs562874; rs11721621; rs10471004; rs540954; rs482641; rs508357; rs577897; rs563857; rs554840; rs506851; rs530934; rs480995; rs537144; rs536446; rs17047634; rs561210; rs11938912; rs505967; rs10001216; rs10020287; rs557687; rs503229; rs493796; rs17047653; rs490103; rs6849060; rs2620407; rs564876; rs1561728; rs2620412; rs525465; rs2583513; rs1479797; rs1866941; rs482683; rs481922; rs541329; rs2389043; rs524021; rs561736; rs566096; rs2620411; rs1904480; rs2583516; rs516638; rs511357; rs2046050; rs479321; rs279536; rs2583517; rs998359; rs279517; rs575703; rs494047; rs1372298; rs1837800; rs481667; rs2620408; rs516109; rs2620418; rs1479799; rs279511; rs499404; rs10002221; rs11098270; rs11931706; rs2018486; rs4834448; rs11939954; rs528983; rs279534; rs9999383; rs2583515; rs10011213; rs498347; rs1020218; rs9991654; rs531435; rs6815981; rs175926; rs6820993; rs6819616; rs6813054; rs9994258; rs538932; rs530616; rs518195; rs2165543; rs580214; rs495797; rs2620413; rs1471500; rs1020219; rs495990; rs279540; rs4404563; rs1441631; rs548896; rs12642789; rs11938588; rs2389042; rs4368622; rs7668760; rs558868; rs483675; rs10005762; rs9993907; rs279520; rs7675371; rs1441638; rs7669112; rs6533830; rs6833579; rs10006039; rs517079; rs11098273; rs2620401; rs279512; rs10012243; rs566388; rs279508; rs7671429; rs10014745; rs533950; rs279537; rs7654560; rs2620409; rs1441630; rs2389040; rs1441637; rs10009553; rs505696; rs12645876; rs9998568; rs279526; rs10015390; rs2620417; rs12642484; rs2389044; rs508583; rs2583514; rs2620424; rs7695449; rs4834447; rs7666328; rs1036757; rs6830598; rs7680119; rs6825790; rs7668694; rs10033537; rs279516; rs6856543; rs1866942; rs500409; rs279538; rs7694381; rs11931643; rs1899334; rs11736926; rs10030514; rs1552025; rs279541; rs2165542; rs7674443; rs2046051; rs11930174; rs7434687; rs11937330; rs569630; rs10516606; rs279528; rs12648274; rs10022934; rs570741; rs11934279; rs11944967; rs17047540; rs1583924; rs1036758; rs536511; rs11938645; rs13128968; rs6810550; rs511927; rs1441639; rs6819065; rs523325; rs11944889; rs6810779; rs279510; rs2620415; rs6812977; rs12645885; rs11941012; rs1842264; rs279519; rs1842263; rs979513; rs17622486; rs4082347; rs498426; rs2620410; rs531594; rs6856510; rs489558; rs10001338; rs573588; rs7671596; rs7670771; rs516919; rs17047475; rs11939952; rs11098271; rs279529; rs11931484; rs12507001; rs7665509; rs11943929; rs10516607; rs17584238; rs529320; rs547928; rs10004817; rs11946779; rs533155; rs4557280; rs279524; rs559670; rs522307; rs17047428; rs2620416; rs6830279; rs10009402; rs1383002; rs526459; rs7689254; rs2892670; rs7670030; rs10007513; rs17679264; rs6811104; rs6849371; rs2583521; rs6810786; rs2028481; rs1530271; rs6843204; rs17047437; rs9884962; rs9998272; rs10516608; rs10000924; rs279505; rs9998848; rs537512; rs6533829; rs1866943; rs6836056; rs11945934; rs9992854; rs499218; rs2389041; rs479528; rs6836349; rs509127; rs279521; rs1583922; rs2620399; rs568713; rs279509; rs1383001; rs2028482; rs10516605; rs2620431; rs13120543; rs2620423; rs6849898; rs12640065; rs17047470; rs2197074; rs482935; rs4472155; rs11936553; rs6844769; rs10026970; rs17047425; rs1583923; rs7671475; rs6811143; rs750417; rs528678; rs279506; rs279522; rs471867; rs10003023; rs7673947; rs7659210; rs12648047; rs550019; rs7656008; rs530167; rs17486477; rs515976; rs11943439; rs2019200; rs9784565; rs4264850; rs12647287; rs17679144; rs12645955; rs7689395; rs11947913; rs11941001; rs4554098; rs11944811; rs6854144; rs502179; rs11736417; rs9991699; rs6811822; rs7679194; rs515070; rs7437758; rs17047468; rs10016617; rs13108625; rs7689327; rs12642116; rs2197075; rs17047537; rs7654894; rs17047524; rs6848957; rs12642139; rs1899335; rs3899756; rs920577; rs11940539; rs2019195; rs279514; rs2218251; rs11939806; rs11940470; rs10857036; rs17047495; rs6419194; rs2583523; rs6858472; rs543088; rs7696060; rs279539; rs10049937; rs4336245; rs9762896; rs279531; rs4090780; rs11734611; rs17047508; rs4530655; rs11946971; rs2083626; rs17679276; rs279518; rs10013031; rs531263; rs9762847; rs2620406; rs6856689; rs11735531; rs11935037; rs12503383; rs511901; rs10001879; rs7687949; rs9992947; rs557173; rs6824591; rs12505140; rs1441628; rs279525; rs554915; rs7663228; rs1383000; rs9997949; rs279532; rs10026976; rs6810389; rs10014430; rs9995811; rs11936530; rs10002405; rs279513; rs10006683; rs279535; rs6850601; rs13138975; rs10029337; rs17047545; rs1978938; rs17623036; rs10004858; rs573421; rs6836286; rs530485; rs899606; rs17047529; rs10222995; rs6849570; rs6844231; rs9762854; rs567976; rs17047492; rs17047419; rs17047463; rs7676598; rs2119664; rs9999215; rs10222706; rs1001815; rs1837802; rs11727410; rs17047534; rs17622677; rs6830803; rs1441633; rs6830396; rs6838296; rs7440344; rs10004337; rs11942204; rs517231; rs533585; rs10030883; rs17622627; rs17047479; rs11931244; rs6812189; rs17583437; rs17486843; rs17679753; rs1479798; rs13115130; rs10008361; rs13131064; rs547427; rs17583766; rs17047431; rs2119663; rs7674844; rs17622816; rs2620400; rs7679531; rs9684691; rs13150766; rs1441632; rs279515; rs17047542; rs11930181; rs6823958; rs6815070; rs11098276; rs4607240; rs12511884; rs11728589; rs10014003; rs1441627; rs11725345; rs11939941; rs7669788; rs17047484; rs16997326; rs7673354; rs1471499; rs10003387; rs17047410; rs13142670; rs7680862; rs17486233; rs12511801; rs482283; rs35181627; rs34847662; rs34134859; rs34045479; rs34623369; rs13128123; rs28783717; rs34597527; rs13128093; rs13152590; rs475668; rs13112177; rs10635710; rs10693090; rs34472301; rs12512835; rs13152038; rs28587893; rs34956339; rs35614861; rs35591411; rs13106842; rs35104189; rs33935748; rs34087427; rs28722150; rs33991012; rs34226280; rs34528236; rs5861203; rs34184149; rs7657227; rs33975225; rs11460236; rs11938344; rs35031671; rs6858866; rs11426438; rs477958; rs10025785; rs9991325; rs33981511; rs34574421; rs7657463; rs28687855; rs35819963; rs10016860; rs10470913; rs10025233; rs35757521; rs28678017; rs35747634; rs36059350; rs35707843; rs9685915; rs4508907; rs1600397; rs559307; rs28695346; rs35574225; rs513782; rs34883816; rs35484731; rs13131643; rs34684234; rs10033025; rs475646; rs34924132; rs28854031; rs13106858; rs2019437; rs28549159; rs35924727; rs5861202; rs33939574; rs34309563; rs491934; rs13152037; rs34452990; rs34598173; rs35164085; rs35761925; rs486615; rs13152177; rs7689538; rs34879124; rs35674542; rs3132822; rs33935242; rs13149623; rs28623688; rs13142564; rs13134223; rs34850904; rs28690869; rs34942096; rs33925339; rs10679782; rs33926517; rs2620419; rs2620425; rs6858653; rs542287; rs13112166; rs35715981; rs12640620; rs11098279; rs34741219; rs12233877; rs35081042; rs2620421; rs11460393; rs35124044; rs13144414; rs35758538; rs13149368; rs34863507; rs6848295; rs33948499; rs28596780; rs1837805; rs2620426; rs35262784; rs9760742; rs693155; rs34688407; rs34389569; rs509591; rs6810460; rs10555403; rs28602418; rs35492732; rs28622422; rs33969019; rs34614261; rs2620420; rs7340931; rs28496867; rs10008033; rs7663777; rs13152100; rs11441566; rs13133429; rs2389061; rs11435788; rs9998053; rs35971842; rs9307410; rs10651752; rs11940938; rs34190385; rs35469679; rs2583522; rs5861197; rs13124861; rs1441635; rs169416; rs34667506; rs34741350; rs11098272; rs28647687; rs33984444; rs35350644; rs7684881; rs4507381; rs17047543; rs28470302; rs6814738; rs28654828; rs28634928; rs28841108; rs33987124; rs28454168; rs534014; rs28714338; rs35061218; rs28648377; rs538924; rs17047536; rs13149624; rs8180156; rs35363930; rs6848302; rs34104366; rs10591934; rs28433013; rs35208794; rs2583519; rs34171851; rs35992236; rs6857099; rs28635970; rs36229502; rs11433054; rs35645731; rs34231121; rs36126200; rs28654447; rs28792405; rs12501272; rs34661550; rs7679175; rs9761718; rs34477080; rs34843969; rs520853; rs35529253; rs28538937; rs9995994; rs11098280; rs10529608; rs28640895; rs34863366; rs35134439; rs34398191; rs28696823; rs13104082; rs34177084; rs35327124; rs34592796; rs6848946; rs17047462; rs34866154; rs13109524; rs6848955; rs35588669; rs28396645; rs35497695; rs9760743; rs28879144; rs11405644; rs36080386; rs28563786; rs2620427; rs35088938; rs4345205; rs1899336; rs34349158; rs28457274; rs6837725; rs33953343; rs28549023; rs188089; rs11460392; rs28560246; rs28521052; rs28564632; rs2583520; rs10019977; rs279507; rs28646187; rs34479190; rs1441629; rs11396814; rs28420758; rs35979278; rs28758805; rs3077815; rs28401715; rs28523432; rs28719532; rs9762553; rs2620402; rs33951232; rs35899989; rs10446725; rs13126512; rs5861198; rs28485691; rs994218; rs34353236; rs28583163; rs34357319; rs2218250; rs34549028; rs34705577; rs35995859; rs11432779; rs5861200; rs28369395; rs13146230; rs36211109; rs530306; rs35066832; rs28727452; rs10682093; rs10615758; rs1837801; rs28433673; rs2583511; rs578285; rs6814955; rs35247707; rs35295440; rs4834449; rs35819730; rs28472632; rs35888388; rs34181479; rs2620422; rs6833754; rs11286132; rs34174566; rs6837715; rs13145875; rs4833469; rs6826385; rs10007433; rs28700231; rs33910952; rs10003921; rs33944193; rs28769381; rs35832883; rs11724358; rs34251892; rs35350731; rs28448721; rs28408781; rs34109567; rs34860647; rs10008694; rs35097855; rs35631339; rs13145278; rs34933883; rs11292247; rs1940295; rs4645229; rs1441634; rs36090257; rs28472459; rs28710395; rs36203738; rs28681493; rs13125045; rs33962515; rs11418590; rs2620414; rs35907948; rs9760755; rs10008192; rs193368; rs35095762; rs4100071; rs7665791; rs28680952; rs33921813; rs5861199; rs28806557; rs36055187; rs34780585; rs13122736; rs28496574; rs1000257; rs35605369; rs11462506; rs11441565; rs17047476; rs28533489; rs11483232; rs35442965; rs13149569; rs28719699; rs11433053; rs34037873; rs33934132; rs10010498; rs13135342; rs33929512; rs13115201; rs2389060; rs35651844; rs10526679; rs35797094; rs3077771; rs3043339; rs35075605; rs9761733; rs13122240; rs9714620; rs1837803; rs28635347; rs35146605; rs3849031; rs10020187; rs4519811; rs9761735; rs13150562; rs28393555; rs13131620; rs34072502; rs6848951; rs34196996; rs10007951; rs34055166; rs36008114; rs28434241; rs10016571; rs34139012; rs6818268; rs33988343; rs35726786; rs5861201; rs6853328; rs28521255; rs2389045; rs2859941; rs1971146; rs28633393; rs35039526; rs7671346; rs17679009; rs28668946; rs35801992; rs28569252; rs13124066; rs28493518; rs35955171; rs35597057; rs4476618; rs34354852; rs13132103; rs34793357; rs34143696; rs28611498; rs6828951; rs35423038; rs34314240; rs17679126; rs28457694; rs6855342; rs34768339; rs4001837; rs36094936; rs12639904; rs34789347; rs4361406; rs35233146; rs35705864; rs12643704; rs35967011; rs10029780; rs28548820; rs7696723; rs35633534; rs279533; rs11932147; rs33976211; rs28498191; rs35652473; rs28404350; rs34241103; rs13150826; rs28465489; rs34279473; rs28490277; rs28525562; rs35516569; rs33919888; rs35676486; rs4306976; rs5861195; rs1837799; rs28892914; rs34682679; rs13136365; rs13150779; rs10006890; rs13104087; rs28410117; rs510247; rs34569627; rs28509283; rs28812915; rs34516136; rs34776826; rs28560123; rs2583518; rs34408777; rs28464565; rs6533831; rs17047446; rs33977537; rs34602372; rs28677056; rs12650241; rs12507013; rs1837804; rs35346250; rs538817; rs35451664; rs28729973; rs2620429; rs34940157; rs35889965; rs36040898; rs35017501; rs12511633; rs6839057; rs13435021; rs35777600; rs1479802; rs3043338; rs279527; rs10018730; rs35366318; rs10030524; rs33922369; rs28612407; rs11931805; rs10654638; rs28434781; rs2127461; rs33917382; rs12641102; rs5861194; rs7663241; rs1561729; rs4834446; rs13152092; rs560680; rs486022; rs573772; rs35075359; rs35047155; rs279530; rs28730954; rs28874071; rs34412219; rs35890208; rs4361407; rs10593709; rs35536995; rs7690267; rs2583524; rs28727924; rs35903634; rs6844298; rs28412091; rs2620428; rs9759996; rs35995903; rs34207802; rs34265214; rs28773816; rs28488142; rs518872; rs13121181; rs10471002; rs35736377; rs9761726; rs28576070; rs35631469; rs36015004; rs33968646; rs6830220; rs4090781; rs34746303; rs34148880; rs17047442; rs6839089; rs279523; rs28622250; rs5861196; rs5027259; rs7693904; rs13150592; rs34909171; rs35749618; rs28587008; rs10591935; rs11350168; rs35830702; rs35473639; rs34275245; rs33922572; rs3840986; rs4299604; rs3840987; rs10013732; rs10013791; rs10013926; rs11936613; rs12640672; rs12646496; rs12646770; rs13103789; rs35438297; rs3898306; rs4512014; rs4574434; rs4640690; rs481502; rs483276; rs518645; rs528860; rs534254; rs547260; rs559777; rs560820; rs6533822; rs7682531

# Metabolic_Enzyme_25_General_References:
11087757

# Metabolic_Enzyme_25_References:
Not Available

# Metabolic_Enzyme_26_ID:
8778

# Metabolic_Enzyme_26_Name:
Heparan sulfate 2-O-sulfotransferase 1

# Metabolic_Enzyme_26_Synonyms:
2-O- sulfotransferase; 2OST

# Metabolic_Enzyme_26_Gene_Name:
HS2ST1

# Metabolic_Enzyme_26_Protein_Sequence:
>Heparan sulfate 2Osulfotransferase 1
MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRSKLERAIARHEVREIEQRHTMD
GPRQDATLDEEEDMVIIYNRVPKTASTSFTNIAYDLCAKNKYHVLHINTTKNNPVMSLQD
QVRFVKNITSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFG
DDYRPGLRRRKQGDKKTFDECVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQA
KYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATELYRTGKKSHLRKTTEKKLPTKQT
IAKLQQSDIWKMENEFYEFALEQFQFIRAHAVREKDGDLYILAQNFFYEKIYPKSN

# Metabolic_Enzyme_26_Number_of_Residues:
356

# Metabolic_Enzyme_26_Molecular_Weight:
41882

# Metabolic_Enzyme_26_Theoretical_pI:
8.97

# Metabolic_Enzyme_26_GO_Classification:
Not Available

# Metabolic_Enzyme_26_General_Function:
Not Available

# Metabolic_Enzyme_26_Specific_Function:
Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high- affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues

# Metabolic_Enzyme_26_Pathway:
Not Available

# Metabolic_Enzyme_26_Reaction:
Not Available

# Metabolic_Enzyme_26_Pfam_Domain_Function:
PF05040:HS2ST

# Metabolic_Enzyme_26_Signals:
1-23

# Metabolic_Enzyme_26_Transmembrane_Regions:
12-28

# Metabolic_Enzyme_26_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_26_EC_Link:
EC 2.8.2.-

# Metabolic_Enzyme_26_GenBank_ID_Protein:
6683564

# Metabolic_Enzyme_26_SwissProt_ID:
HS2ST_HUMAN (Q7LGA3)

# Metabolic_Enzyme_26_swissprot_Name:
Not Available

# Metabolic_Enzyme_26_Genecard_id:
HS2ST1

# Metabolic_Enzyme_26_Geneatlas_id:
HS2ST1

# Metabolic_Enzyme_26_hgnc_id:
HGNC:5193

# Metabolic_Enzyme_26_PDB_ID:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_26_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_26_Gene_Sequence:
>1071 bp
ATGGGGCTCCTCAGGATTATGATGCCGCCCAAGTTGCAGCTGCTGGCGGTGGTGGCCTTC
GCGGTGGCGATGCTCTTCTTGGAAAACCAGATCCAGAAACTGGAGGAGTCCCGCTCGAAG
CTAGAAAGGGCTATTGCAAGACACGAAGTCCGAGAAATTGAGCAGCGACATACAATGGAT
GGCCCTCGGCAAGATGCCACTTTAGATGAGGAAGAGGACATGGTGATCATTTATAACAGA
GTTCCCAAAACGGCAAGCACTTCATTTACCAATATCGCCTATGACCTGTGTGCAAAGAAT
AAATACCATGTCCTTCATATCAACACTACCAAAAATAATCCAGTGATGTCATTGCAAGAT
CAGGTGCGCTTTGTAAAGAATATAACTTCCTGGAAAGAGATGAAACCAGGATTTTATCAT
GGACACGTTTCTTACTTGGATTTTGCAAAATTTGGTGTGAAGAAGAAACCAATTTACATT
AATGTCATAAGGGATCCTATTGAGAGGCTAGTTTCTTATTATTACTTTCTGAGATTTGGA
GATGATTATAGACCAGGGTTACGGAGACGAAAACAAGGAGACAAAAAGACCTTTGATGAA
TGTGTAGCAGAAGGTGGCTCAGACTGTGCTCCAGAGAAGCTCTGGCTTCAAATCCCGTTC
TTCTGTGGCCATAGCTCCGAATGCTGGAATGTGGGAAGCAGGTGGGCTATGGATCAAGCC
AAGTATAACCTAATTAATGAATATTTTCTGGTGGGAGTTACTGAAGAACTTGAAGATTTT
ATCATGTTATTGGAGGCAGCATTGCCCCGGTTTTTCAGGGGTGCTACTGAACTCTATCGC
ACAGGAAAGAAATCTCATCTTAGGAAAACCACAGAGAAGAAACTCCCCACTAAACAAACC
ATTGCAAAACTACAGCAATCTGATATTTGGAAAATGGAGAATGAGTTCTATGAATTTGCA
CTAGAGCAGTTCCAATTCATCAGAGCCCATGCCGTTCGAGAAAAAGATGGAGACCTCTAC
ATCCTCGCACAAAACTTTTTCTATGAAAAGATTTACCCTAAGTCGAACTGA

# Metabolic_Enzyme_26_GenBank_ID_Gene:
AB024568

# Metabolic_Enzyme_26_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_26_Locus:
1p31.1-p22.1

# Metabolic_Enzyme_26_SNPs:
rs1621247; rs2798682; rs2798684; rs2764430; rs3766018; rs2798683; rs12024938; rs1419132; rs2390215; rs2764425; rs2040064; rs1317064; rs2154041; rs1778012; rs2764427; rs2798674; rs1419131; rs2892962; rs6663088; rs1112998; rs4508067; rs2798675; rs1936282; rs6661530; rs2764426; rs7519975; rs6576860; rs2807950; rs7513224; rs4656136; rs12135819; rs10493794; rs2390264; rs1539610; rs6659529; rs4656139; rs2390214; rs4610985; rs3929937; rs1936280; rs4518960; rs2798676; rs12036844; rs7524526; rs10747335; rs2064889; rs7552285; rs2753275; rs1407132; rs10873819; rs11579734; rs1891833; rs10782592; rs12128231; rs4656133; rs1199732; rs1573202; rs7543542; rs7531296; rs4311860; rs7553360; rs6697595; rs6689714; rs7529516; rs2753273; rs6576858; rs4656135; rs12756724; rs6674591; rs1199726; rs2390221; rs10747338; rs6696540; rs4233338; rs17418454; rs4656138; rs11161928; rs7535477; rs1741974; rs17452535; rs6663434; rs2753272; rs10782590; rs1408844; rs10873807; rs1201784; rs12139634; rs10127488; rs1936281; rs2390220; rs1923144; rs6702601; rs4656141; rs11161914; rs6684654; rs7546808; rs11579474; rs7534656; rs6693677; rs2390225; rs2783976; rs1778013; rs4484904; rs1199677; rs4656129; rs7536241; rs1343393; rs2807951; rs4431894; rs11584931; rs3949926; rs2154042; rs11161930; rs11585015; rs2027563; rs12072434; rs1970607; rs4357505; rs17418600; rs6576856; rs2064888; rs4656137; rs2390224; rs10873816; rs4656134; rs9970191; rs7515120; rs6667301; rs10873809; rs2390222; rs2753270; rs472509; rs12086868; rs7546043; rs4656125; rs6689089; rs6703683; rs7556130; rs4655922; rs10157490; rs10782587; rs6697798; rs6695270; rs10873817; rs10158758; rs7527182; rs17419515; rs1778004; rs2390218; rs7546525; rs7531090; rs7528208; rs797935; rs10158755; rs7534815; rs12066353; rs2753276; rs7534974; rs1199679; rs1199733; rs11161918; rs2798677; rs12401302; rs10873814; rs10157491; rs2064890; rs7545052; rs6576859; rs6656617; rs7545049; rs12406735; rs6688771; rs4290035; rs6684125; rs6693974; rs6704152; rs1125279; rs1749448; rs6673018; rs10159338; rs7552504; rs1778014; rs7544881; rs7542636; rs7541261; rs6576861; rs7553423; rs11161917; rs10732725; rs7545567; rs11161921; rs533981; rs12095044; rs7354923; rs10158757; rs10782591; rs10873818; rs10747334; rs1778010; rs1199728; rs10489917; rs12067466; rs17099785; rs7545731; rs10747331; rs7544803; rs12077001; rs1199724; rs10873806; rs11161929; rs4655920; rs11161934; rs10782589; rs1199680; rs11161922; rs10873810; rs9988546; rs1199731; rs7534276; rs6661216; rs1972394; rs11161926; rs2390223; rs2390217; rs6681928; rs11582674; rs10782588; rs4606291; rs10157492; rs11583647; rs7536648; rs1778006; rs11161916; rs17129775; rs12078418; rs12086482; rs12047992; rs2096286; rs2390219; rs7534355; rs7516414; rs12094478; rs12401907; rs2753274; rs4623671; rs6699760; rs1054643; rs12073343; rs1778011; rs10747332; rs1199678; rs7516833; rs12025384; rs2185934; rs11161927; rs11161919; rs12096102; rs2753277; rs12563374; rs4655921; rs10873815; rs3208633; rs35094622; rs2274231; rs41311182; rs41296175; rs17129815; rs11548570; rs41300335; rs35272291; rs41302770; rs41313379; rs34778502; rs12140328; rs15436; rs2972003; rs12566411; rs7411354; rs35368782; rs35251857; rs12121812; rs12094141; rs35342652; rs12754550; rs11345061; rs6671040; rs41287739; rs11584534; rs34116330; rs35738255; rs6699191; rs11590439; rs11427568; rs34124612; rs5775931; rs6684202; rs28475787; rs35752857; rs12065084; rs34769860; rs11590936; rs12086416; rs11378552; rs11361251; rs35324898; rs9970318; rs1778008; rs35421782; rs12039376; rs34508847; rs3030717; rs12095182; rs12217117; rs11487920; rs11812008; rs12075484; rs11161924; rs34858634; rs35207857; rs9433114; rs35771069; rs10593070; rs6685983; rs6691180; rs28614112; rs34503404; rs10582979; rs978573; rs7520615; rs34227325; rs34675395; rs34796375; rs1199730; rs35154026; rs10747333; rs11341142; rs4656127; rs5775927; rs6696808; rs35048806; rs12059632; rs36033622; rs10873812; rs11577549; rs6692431; rs12057835; rs7536637; rs11161933; rs35684247; rs35248679; rs2390213; rs11454448; rs34304767; rs34993861; rs34250106; rs34175700; rs34367810; rs11321615; rs12068864; rs6658900; rs12723618; rs6671008; rs12080431; rs12737567; rs12734831; rs11161925; rs1199676; rs2892963; rs1778007; rs10531209; rs6681197; rs6703654; rs28368799; rs11448145; rs34223128; rs6684382; rs12116811; rs6674397; rs35195228; rs4619019; rs6675767; rs10550274; rs2390226; rs12090617; rs12129946; rs11161911; rs33993967; rs10568899; rs35247051; rs1199725; rs35903975; rs11434564; rs35522446; rs34773873; rs12034001; rs12031983; rs33933183; rs11397336; rs6667908; rs9433115; rs5775929; rs35417887; rs10873813; rs1778003; rs12727069; rs3031556; rs11284968; rs11161931; rs11423322; rs12756056; rs4001043; rs35019329; rs35963471; rs10646251; rs568243; rs12135569; rs5775933; rs7554990; rs7540789; rs12035011; rs5775928; rs35388044; rs12133040; rs7514045; rs6675657; rs12119352; rs12044409; rs10582980; rs35261014; rs2390212; rs35375981; rs12121467; rs10747336; rs34487901; rs6676600; rs6694314; rs11361500; rs35570511; rs34812948; rs11284177; rs2096287; rs34130014; rs6684201; rs34631101; rs9970311; rs6693213; rs10716207; rs11161913; rs12082479; rs34865280; rs12023082; rs12043164; rs34720817; rs28536635; rs35901051; rs35850802; rs12034081; rs12728814; rs34021754; rs34702304; rs11427551; rs35424696; rs10553385; rs35768638; rs12756699; rs11377056; rs12734749; rs7546436; rs13375096; rs10747339; rs12028006; rs34226140; rs11463105; rs12061324; rs5775934; rs12062091; rs2474928; rs10712568; rs6665326; rs34985940; rs34470488; rs17418683; rs28399143; rs12087294; rs10597886; rs1199727; rs12142941; rs35311251; rs12137990; rs34921088; rs7546697; rs35630628; rs6691627; rs35750668; rs35562442; rs35326269; rs12125030; rs28593495; rs4656126; rs35948679; rs36005007; rs35780005; rs33945950; rs1778009; rs35669188; rs9887928; rs35338591; rs12086289; rs11373445; rs34820915; rs35688602; rs35765527; rs10689285; rs1936279; rs1199729; rs12565815; rs35290925; rs35596155; rs35782428; rs34142522; rs11417863; rs34820042; rs11463433; rs4655919; rs36109552; rs35778762; rs35997529; rs12722890; rs36024956; rs36073740; rs6576857; rs34352146; rs10747337; rs10873811; rs12076088; rs35179674; rs35225648; rs12088355; rs35183934; rs36023844; rs10708896; rs34669015; rs12076952; rs11538136; rs4408126; rs11161923; rs36113999; rs5775926; rs11377612; rs12568972; rs34924970; rs2390216; rs4656130; rs10553384; rs28425638; rs10584804; rs34073711; rs36139352; rs7519996; rs35791774; rs35085890; rs34719509; rs35417646; rs12130693; rs34173959; rs35211030; rs28540736; rs12132849; rs35801886; rs28449185; rs12354092; rs35510312; rs34838523; rs28869601; rs10873805; rs7547021; rs4656128; rs35133844; rs12029167; rs35970166; rs1125278; rs11327026; rs9988565; rs34024885; rs7553225; rs34164905; rs11585432; rs12024560; rs1058179; rs101028; rs11161932; rs1199666; rs1199667; rs1199668; rs1199669; rs1199670; rs1199671; rs1199672; rs12078338; rs12096673; rs12120670; rs12408843; rs12727774; rs12727879; rs1407131; rs1419130; rs2764431; rs2783977; rs34766716; rs3753286; rs3766015; rs487006; rs490093; rs499587; rs527281; rs531915; rs546745; rs548649; rs561104; rs561728; rs578851; rs6576864; rs754001; rs797933; rs9433110

# Metabolic_Enzyme_26_General_References:
9455484

# Metabolic_Enzyme_26_References:
Not Available

# Metabolic_Enzyme_27_ID:
8794

# Metabolic_Enzyme_27_Name:
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3

# Metabolic_Enzyme_27_Synonyms:
Glucosaminyl N-deacetylase/N-sulfotransferase 3; NDST- 3; hNDST-3; N-heparan sulfate sulfotransferase 3; N-HSST 3[Includes: Heparan sulfate N-deacetylase 3

# Metabolic_Enzyme_27_Gene_Name:
NDST3

# Metabolic_Enzyme_27_Protein_Sequence:
>Bifunctional heparan sulfate Ndeacetylase/Nsulfotransferase 3
MSFIMKLHRHFQRTVILLATFCMVSIIISAYYLYSGYKQENELSETASEVDCGDLQHLPY
QLMEVKAMKLFDASRTDPTVLVFVESQYSSLGQDIIMILESSRFQYHIEIAPGKGDLPVL
IDKMKGKYILIIYENILKYINMDSWNRSLLDKYCVEYGVGVIGFHKTSEKSVQSFQLKGF
PFSIYGNLAVKDCCINPHSPLIRVTKSSKLEKGSLPGTDWTVFQINHSAYQPVIFAKVKT
PENLSPSISKGAFYATIIHDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLS
LDRYILVDIDDIFVGKEGTRMNTNDVKALLDTQNLLRAQITNFTFNLGFSGKFYHTGTEE
EDEGDDCLLGSVDEFWWFPHMWSHMQPHLFHNESSLVEQMILNKKFALEHGIPTDMGYAV
APHHSGVYPVHVQLYEAWKKVWNIKITSTEEYPHLKPARYRRGFIHKNIMVLPRQTCGLF
THTIFYKEYPGGPKELDKSIQGGELFFTVVLNPISIFMTHLSNYGNDRLGLYTFVNLANF
VKSWTNLRLQTLPPVQLAHKYFELFPDQKDPLWQNPCDDKRHRDIWSKEKTCDRLPKFLV
IGPQKTGTTALYLFLVMHPSILSNSPSPKTFEEVQFFNRNNYHRGIDWYMDFFPVPSNVT
TDFLFEKSANYFHSEEAPKRAASLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALKFS
FYEVISAGPRAPSELRALQKRCLVPGWYASHIERWLVYFPPFQLLIIDGQQLRTDPATVM
DEVQKFLGVLPHYNYSEALTFDSHKGFWCQLLEEGKTKCLGKSKGRKYPPMDSDSRTFLS
SYYRDHNVELSKLLHKLGQPLPSWLRQELQKVR

# Metabolic_Enzyme_27_Number_of_Residues:
873

# Metabolic_Enzyme_27_Molecular_Weight:
100903

# Metabolic_Enzyme_27_Theoretical_pI:
8.17

# Metabolic_Enzyme_27_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_27_General_Function:
Not Available

# Metabolic_Enzyme_27_Specific_Function:
Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity

# Metabolic_Enzyme_27_Pathway:
Not Available

# Metabolic_Enzyme_27_Reaction:
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine

# Metabolic_Enzyme_27_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_27_Signals:
1-30

# Metabolic_Enzyme_27_Transmembrane_Regions:
14-34

# Metabolic_Enzyme_27_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_27_EC_Link:
EC 2.8.2.8

# Metabolic_Enzyme_27_GenBank_ID_Protein:
4322247

# Metabolic_Enzyme_27_SwissProt_ID:
NDST3_HUMAN (O95803)

# Metabolic_Enzyme_27_swissprot_Name:
Not Available

# Metabolic_Enzyme_27_Genecard_id:
NDST3

# Metabolic_Enzyme_27_Geneatlas_id:
NDST3

# Metabolic_Enzyme_27_hgnc_id:
HGNC:7682

# Metabolic_Enzyme_27_PDB_ID:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_27_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_27_Gene_Sequence:
>2622 bp
ATGAGTTTTATCATGAAGCTTCACAGACACTTTCAAAGAACAGTCATTCTGCTTGCCACT
TTTTGTATGGTGAGCATTATCATTTCTGCTTACTACCTGTACAGTGGCTACAAACAGGAA
AATGAACTCTCTGAGACGGCTTCAGAAGTTGACTGTGGCGACCTCCAACACCTACCATAT
CAACTAATGGAAGTGAAAGCAATGAAGCTTTTTGATGCCTCAAGGACAGACCCCACAGTC
CTAGTATTTGTAGAGAGCCAGTACTCATCTCTTGGTCAAGACATCATTATGATTCTAGAA
TCAAGTAGATTCCAGTATCACATTGAAATTGCCCCTGGAAAGGGAGATCTCCCAGTGCTT
ATAGACAAAATGAAAGGCAAATACATTCTCATTATTTATGAGAATATTTTAAAGTATATA
AATATGGATTCCTGGAATCGAAGCCTTCTAGATAAATACTGTGTAGAATATGGTGTGGGT
GTCATTGGATTCCACAAAACTAGTGAGAAGAGTGTACAGAGCTTTCAGTTAAAAGGTTTC
CCTTTTTCCATATATGGAAATCTTGCAGTAAAAGATTGTTGTATTAATCCTCATTCTCCA
TTGATTCGTGTGACCAAATCTTCCAAGCTTGAAAAAGGTTCTTTACCTGGAACTGACTGG
ACAGTTTTTCAGATTAATCATTCAGCCTATCAACCAGTAATATTTGCCAAAGTAAAGACC
CCAGAAAACCTTTCTCCTTCCATCTCTAAAGGTGCTTTTTATGCCACTATTATACATGAC
CTGGGGCTTCATGATGGAATTCAAAGGGTTCTTTTTGGCAACAACTTGAACTTTTGGCTG
CACAAGCTCATCTTCATAGATGCCATCTCCTTCTTATCAGGGAAGAGGCTGACATTGTCC
TTGGACAGGTACATTCTTGTGGATATTGATGATATATTTGTGGGAAAAGAGGGAACAAGA
ATGAACACCAATGATGTAAAGGCCCTGCTTGATACTCAGAATCTTTTGCGTGCACAAATC
ACAAATTTTACATTCAACCTGGGATTTTCAGGGAAATTTTACCATACAGGAACTGAAGAG
GAAGATGAAGGAGATGACTGTCTGTTGGGGTCTGTGGATGAGTTCTGGTGGTTTCCTCAC
ATGTGGAGCCATATGCAGCCCCACCTCTTCCACAATGAGTCATCTTTGGTGGAGCAGATG
ATTCTCAACAAAAAATTTGCCTTAGAGCACGGCATTCCAACGGACATGGGCTACGCTGTG
GCCCCTCACCATTCGGGCGTCTACCCTGTACATGTTCAGCTTTATGAGGCCTGGAAGAAG
GTCTGGAATATTAAAATCACCAGCACTGAAGAATATCCACATCTGAAGCCAGCTAGATAC
CGGAGGGGTTTTATCCACAAAAACATCATGGTTCTCCCAAGACAAACCTGTGGGCTTTTC
ACTCACACCATTTTCTACAAAGAATATCCAGGGGGTCCTAAAGAGCTGGATAAGAGTATC
CAAGGAGGAGAACTTTTCTTCACTGTCGTCCTCAACCCTATCAGCATTTTCATGACCCAT
TTGTCCAACTATGGGAATGACCGACTGGGATTATATACATTTGTTAATCTGGCCAACTTT
GTGAAGAGCTGGACCAACCTGCGACTTCAGACTCTGCCTCCAGTACAACTGGCCCACAAG
TATTTTGAGCTGTTTCCTGATCAGAAAGACCCTCTCTGGCAGAATCCTTGCGATGACAAA
CGCCACAGAGACATTTGGTCTAAAGAAAAAACTTGTGATCGCTTACCAAAATTCTTGGTA
ATAGGACCCCAGAAAACTGGTACCACTGCTTTGTATTTGTTCCTGGTTATGCATCCTTCC
ATCCTTAGTAACTCCCCCAGCCCAAAAACCTTTGAGGAGGTACAGTTCTTTAATAGAAAT
AACTACCACAGGGGGATTGATTGGTATATGGATTTCTTCCCAGTCCCATCTAATGTCACT
ACCGACTTTTTGTTTGAGAAGAGTGCCAATTACTTCCACTCAGAGGAAGCCCCTAAAAGA
GCTGCTTCTCTGGTTCCCAAAGCCAAGATTATCACCATTCTCATTGACCCTTCAGACCGA
GCATACTCCTGGTACCAGCATCAGCGATCACATGAAGACCCTGCAGCTCTGAAGTTTAGC
TTCTACGAAGTGATCTCAGCAGGGCCCCGTGCACCCTCGGAGCTCAGAGCCTTGCAGAAG
AGATGTTTGGTCCCGGGGTGGTATGCCAGCCACATCGAGAGATGGCTTGTTTATTTCCCC
CCATTTCAGTTGCTAATTATTGATGGGCAACAACTAAGAACTGATCCTGCTACAGTGATG
GATGAAGTACAGAAGTTTCTAGGAGTCTTGCCTCATTATAATTACTCAGAAGCTTTAACG
TTTGATTCTCATAAAGGTTTCTGGTGTCAGTTACTGGAAGAAGGTAAAACAAAATGCCTT
GGAAAGAGCAAAGGAAGAAAATACCCTCCAATGGATTCTGATAGCAGGACATTTCTGTCA
AGCTACTATCGAGATCACAACGTGGAACTCTCAAAGCTGCTGCACAAACTGGGTCAGCCT
CTGCCATCCTGGCTGAGACAGGAGCTGCAGAAAGTAAGATAG

# Metabolic_Enzyme_27_GenBank_ID_Gene:
AF074924

# Metabolic_Enzyme_27_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_27_Locus:
4q26

# Metabolic_Enzyme_27_SNPs:
rs617430; rs10028980; rs17049697; rs11934022; rs10012897; rs13138385; rs13152576; rs6534079; rs10857057; rs7657704; rs7656160; rs11098420; rs2389498; rs13149783; rs9999038; rs11737538; rs4328979; rs2389497; rs12500561; rs7683628; rs13125367; rs10029850; rs11734982; rs7683496; rs4569815; rs13149429; rs11731535; rs2389523; rs2892790; rs586224; rs2389527; rs2389519; rs615837; rs2389516; rs2204269; rs2389526; rs2389517; rs2030633; rs2030634; rs611659; rs11730541; rs4834672; rs2892800; rs633398; rs4834667; rs12711064; rs2389503; rs2389518; rs10026541; rs11931079; rs9999336; rs1829910; rs13134901; rs4240314; rs1589718; rs6855052; rs4834668; rs11098425; rs4616829; rs10028823; rs10018844; rs7669618; rs4833564; rs11947244; rs4428355; rs6534082; rs650460; rs11944227; rs2389520; rs1523748; rs6853879; rs6851494; rs678177; rs1996725; rs2389501; rs12642204; rs7689231; rs2389510; rs4327555; rs12506091; rs4240320; rs2389500; rs13435006; rs1872771; rs4833560; rs2389521; rs7655439; rs1589719; rs7664383; rs7655519; rs11933280; rs2389502; rs640713; rs6822996; rs10022145; rs6842491; rs788662; rs13119835; rs2389524; rs10030249; rs631271; rs11736688; rs6824418; rs6534084; rs3107483; rs1949760; rs7685455; rs1829911; rs11098424; rs4833561; rs11945921; rs17049695; rs2389512; rs586073; rs10028343; rs11933537; rs4834661; rs6842524; rs10008049; rs13127321; rs10014096; rs6816778; rs12506555; rs11940107; rs1403846; rs11934128; rs11098421; rs6823328; rs4240315; rs17049650; rs613083; rs6857232; rs788664; rs7661325; rs10020944; rs7654521; rs12508017; rs9685965; rs2389509; rs3817274; rs17593877; rs11947911; rs613443; rs17049656; rs4240319; rs687492; rs6820851; rs10023656; rs13104251; rs11727684; rs11727817; rs2892788; rs7654652; rs7689157; rs11945777; rs1319938; rs6857041; rs625546; rs6823295; rs4833563; rs11098422; rs11945329; rs17593919; rs4240318; rs10014957; rs2892799; rs11945958; rs17626497; rs2389515; rs2271577; rs607961; rs10015485; rs9992827; rs17594018; rs7671173; rs7688063; rs17049622; rs11098426; rs4240313; rs6534088; rs11946755; rs6820367; rs7687849; rs13123722; rs7435331; rs11946833; rs13114895; rs17049699; rs11098429; rs10019969; rs13142184; rs11940880; rs11726746; rs13123277; rs4318721; rs9995675; rs6818042; rs17049694; rs11947630; rs11945882; rs11944236; rs10012359; rs4558930; rs4834665; rs13114867; rs615517; rs17692850; rs11930405; rs7439663; rs2892791; rs6842393; rs6855536; rs11933599; rs7688443; rs11931769; rs6856076; rs13114621; rs6848301; rs11731179; rs10213280; rs4571408; rs11943650; rs10518291; rs10002634; rs11098430; rs6842651; rs17593793; rs2389567; rs4240316; rs2389506; rs11947605; rs6534089; rs2389508; rs4452509; rs609512; rs11098428; rs1403845; rs2271578; rs7679658; rs10033308; rs9637622; rs10021781; rs17049690; rs618177; rs17049700; rs10007553; rs10033678; rs788663; rs13139875; rs11727421; rs7695706; rs11730687; rs11728941; rs4834660; rs4147038; rs11947552; rs10015232; rs2049362; rs10020473; rs11934183; rs1916686; rs6842507; rs6822408; rs7671515; rs9996753; rs11930876; rs6842558; rs10024548; rs6820108; rs7671434; rs11942974; rs10001247; rs10004607; rs11937777; rs10440400; rs2140475; rs597881; rs6835860; rs11098427; rs11722698; rs11944865; rs13111697; rs581739; rs11934324; rs6837896; rs7678461; rs10016011; rs11945026; rs4834656; rs10025029; rs11946772; rs660905; rs6842719; rs11730611; rs11722962; rs9992747; rs3749506; rs17049570; rs6835510; rs17049627; rs6842372; rs11941660; rs6823125; rs11932087; rs7677274; rs2389513; rs6820061; rs4546313; rs17049706; rs17049693; rs10024459; rs6842557; rs13434652; rs10018706; rs10030269; rs2389504; rs593966; rs10008013; rs11931778; rs17594243; rs6813615; rs17049630; rs10016301; rs9790637; rs4397073; rs11935069; rs17049609; rs12641173; rs6825105; rs7671359; rs11940076; rs17049676; rs11942654; rs11723877; rs17515832; rs12374268; rs7671562; rs6848037; rs10023699; rs6852565; rs2892789; rs13104129; rs2892785; rs11931869; rs4834670; rs10023964; rs9996762; rs13138982; rs11931409; rs1523746; rs9637623; rs11930782; rs4833565; rs11937205; rs10001926; rs13434825; rs17049626; rs10001520; rs2389505; rs1608506; rs10016206; rs4576085; rs7687505; rs10016285; rs7699653; rs1523747; rs2389507; rs9998981; rs662581; rs11945537; rs2389514; rs7688806; rs631623; rs4131600; rs10033918; rs9684393; rs13130953; rs4147036; rs11098423; rs10031402; rs11938502; rs662086; rs9991787; rs4240317; rs6852469; rs7671232; rs10012196; rs10012051; rs2892786; rs4833566; rs10024837; rs2308027; rs4280816; rs17049625; rs17626479; rs13149888; rs17594054; rs12504529; rs10025690; rs7684275; rs16997442; rs11941062; rs17049648; rs7681830; rs10004592; rs17049698; rs17594257; rs10014055; rs9998199; rs7670397; rs6842689; rs4834673; rs10021970; rs12640268; rs13135646; rs11733562; rs13140433; rs11932297; rs13151098; rs4569819; rs10033927; rs13126882; rs12501122; rs13141841; rs7661522; rs17626520; rs2389525; rs17049588; rs4834666; rs11943088; rs1994384; rs11728724; rs2389522; rs11726838; rs11733528; rs641962; rs11939817; rs7685325; rs6534078; rs6534077; rs7671497; rs35086179; rs35147253; rs10011715; rs13118131; rs12648773; rs7436139; rs35238894; rs12648006; rs13110631; rs34916324; rs10006024; rs34883631; rs13134931; rs13144249; rs2892784; rs35050001; rs34646125; rs13110642; rs12502898; rs2389496; rs28812911; rs13134916; rs2389495; rs35267341; rs10020284; rs33930999; rs28729926; rs34730378; rs13119849; rs7683791; rs2389499; rs35245189; rs12501652; rs4001572; rs13110657; rs13123909; rs13133776; rs35257604; rs7662255; rs34893788; rs12501383; rs28648504; rs34795498; rs7436325; rs35359278; rs5861377; rs7435948; rs34835262; rs12498683; rs1608505; rs35263017; rs3080149; rs28847022; rs36035970; rs34812479; rs34623333; rs3830507; rs34564513; rs6853684; rs4833567; rs12505156; rs13131380; rs36227842; rs35826097; rs35938936; rs17049649; rs34302716; rs10027013; rs10607535; rs35776915; rs28848859; rs33922704; rs34143377; rs28715892; rs35580866; rs9991087; rs1523744; rs10702072; rs5861375; rs28697099; rs2892787; rs35491780; rs35821057; rs13121129; rs7666861; rs35683434; rs11335648; rs35034865; rs36208859; rs35573813; rs28562324; rs35216924; rs13149170; rs10628437; rs28734874; rs4833562; rs13134451; rs34452190; rs28781349; rs4566725; rs13134833; rs33985434; rs28669076; rs34924654; rs10633685; rs10002892; rs11416507; rs11722023; rs2271579; rs11448394; rs35054481; rs1343827; rs13131971; rs28706008; rs35094555; rs35218485; rs41278065; rs35704864; rs4834664; rs673682; rs17515651; rs12505418; rs28851582; rs34872510; rs35237651; rs36207620; rs28667401; rs13137083; rs4400066; rs36127253; rs28886020; rs11728964; rs35139409; rs34756619; rs1523749; rs35995808; rs35073718; rs34315750; rs11439726; rs12331617; rs676802; rs35375764; rs36006756; rs34255267; rs28789108; rs34909956; rs28500762; rs4546315; rs5742375; rs13127368; rs11298940; rs28723489; rs10004800; rs35754873; rs5861383; rs35715840; rs4147039; rs28847597; rs11384076; rs28576396; rs7356311; rs17515561; rs34008240; rs36117603; rs11281529; rs10003652; rs5861378; rs5861380; rs35988831; rs35960010; rs35910994; rs788661; rs13131623; rs11297151; rs28567841; rs13132331; rs9968544; rs28631338; rs34054720; rs4404621; rs34242038; rs10033412; rs34918708; rs35648060; rs6828552; rs35502256; rs28771156; rs34872625; rs28683619; rs35946502; rs34418586; rs35051708; rs35138500; rs11737224; rs5861376; rs6824718; rs28819697; rs13123381; rs11737229; rs33994401; rs34285969; rs34185290; rs34558995; rs34655188; rs34872487; rs35694467; rs34764099; rs28507199; rs9996857; rs35017662; rs28711393; rs28646146; rs28555974; rs6856765; rs11724386; rs35872631; rs11299569; rs4502754; rs28634983; rs5861382; rs35792741; rs34595271; rs34626006; rs11947071; rs35099667; rs36070709; rs13113258; rs10633686; rs28484271; rs10007959; rs17593863; rs13114249; rs35851865; rs35051152; rs28665669; rs11322429; rs28856120; rs28740899; rs34290697; rs28665169; rs28393351; rs33984401; rs35661296; rs35210682; rs28885399; rs11298939; rs34475822; rs4834657; rs33972233; rs9307452; rs28619162; rs34213306; rs10568846; rs28558085; rs10030449; rs13135500; rs35844977; rs10027893; rs4557347; rs28434240; rs35754081; rs34345840; rs35475347; rs28728238; rs6847359; rs34826732; rs33931637; rs33936644; rs10014402; rs11336961; rs10007381; rs35591587; rs28682376; rs34714560; rs34711397; rs34563259; rs28766305; rs12505582; rs11728950; rs12108668; rs10656718; rs28396926; rs28479964; rs28507472; rs35554727; rs28889086; rs10021128; rs35235550; rs35018183; rs34017200; rs11419568; rs11347319; rs11294350; rs28688245; rs4362895; rs4834658; rs35307549; rs7654695; rs10005348; rs34004725; rs34405308; rs28753894; rs10025515; rs35983699; rs28600918; rs33977562; rs10007918; rs34646523; rs10031257; rs35067389; rs4502667; rs35641856; rs28776305; rs41278063; rs28826087; rs35524586; rs10440401; rs34190534; rs28524963; rs28536042; rs28711185; rs36098020; rs34994076; rs28421577; rs35749089; rs36218730; rs13106276; rs28396217; rs34419266; rs33966390; rs10669730; rs36119137; rs28631152; rs28668316; rs7661076; rs34171033; rs35652422; rs28690846; rs28708693; rs36139871; rs13120016; rs35492744; rs34730310; rs10024910; rs34835669; rs7439873; rs34182759; rs666558; rs10681234; rs13132346; rs34872062; rs36219518; rs35381491; rs34782963; rs5861379; rs36229372; rs34176697; rs35789417; rs12511554; rs28589481; rs10025979; rs28498433; rs11380294; rs10027703; rs35876590; rs5861381; rs10535482; rs13125461; rs28667022; rs34850426; rs10005512; rs28515963; rs28768382; rs34238547; rs10030057; rs4437319; rs34834977; rs35294396; rs7665014; rs10004528; rs35238803; rs36053074; rs11729027; rs35816742; rs35254931; rs35528360; rs36214652; rs34466659; rs10050326; rs10014154; rs13136897; rs34463969; rs35137516; rs28399774; rs35650624; rs35112049; rs34804902; rs33926182; rs33979318; rs28603319; rs3838634; rs34835050; rs35641809; rs28378646; rs35077679; rs34248952; rs34101813; rs35192544; rs28687476; rs11408271; rs33927682; rs34723948; rs10006223; rs34660107; rs13109564; rs4519863; rs28374287; rs10011099; rs2389511; rs6845921; rs13129847; rs34639699; rs644797; rs1523745; rs10569298; rs10023858; rs35188223; rs2389566; rs13103629; rs35250714; rs35647802; rs36081446; rs28508556; rs28627299; rs34891564; rs36092065; rs12505642; rs35621837; rs35982667; rs13113193; rs10025340; rs28430981; rs28375657; rs4544776; rs34091625; rs35433749; rs28823876; rs35284850; rs13109168; rs35204114; rs10005659; rs10024765; rs34165051; rs34224588; rs7686670; rs613149; rs33953463; rs34004705; rs34525909; rs35754899; rs12499751; rs28630407; rs6848598; rs4147040; rs35472465; rs10213202; rs13125397; rs33923588; rs10613667; rs35760279; rs33971782; rs34293412; rs28882407; rs35553303; rs11396935; rs17049590; rs9993556; rs6148636; rs28369617; rs33928766; rs28667620; rs10682796; rs34548920; rs34644680; rs34915366; rs34436506; rs11934512; rs28656282; rs28625833; rs28478577; rs4526047; rs35943639; rs35276919; rs10000049; rs11727769; rs11935016; rs11946941; rs12509230; rs1318459; rs1319061; rs17594447; rs2138009; rs2254204; rs2254215; rs2254218; rs2291416; rs2389491; rs2389492; rs2389493; rs3134; rs34514948; rs35612621; rs4438821; rs4479780; rs4577651; rs582448; rs608228; rs6534074; rs656079; rs7687673; rs7688055

# Metabolic_Enzyme_27_General_References:
9915799; 12975309

# Metabolic_Enzyme_27_References:
Not Available

# Metabolic_Enzyme_28_ID:
8820

# Metabolic_Enzyme_28_Name:
Uronyl 2-sulfotransferase

# Metabolic_Enzyme_28_Synonyms:
Not Available

# Metabolic_Enzyme_28_Gene_Name:
UST

# Metabolic_Enzyme_28_Protein_Sequence:
>Uronyl 2sulfotransferase
MKKKQQHPGGGADPWPHGAPMGGAPPGLGSWKRRVPLLPFLRFSLRDYGFCMATLLVFCL
GSLLYQLSGGPPRFLLDLRQYLGNSTYLDDHGPPPSKVLPFPSQVVYNRVGKCGSRTVVL
LLRILSEKHGFNLVTSDIHNKTRLTKNEQMELIKNISTAEQPYLFTRHVHFLNFSRFGGD
QPVYINIIRDPVNRFLSNYFFRRFGDWRGEQNHMIRTPSMRQEERYLDINECILENYPEC
SNPRLFYIIPYFCGQHPRCREPGEWALERAKLNVNENFLLVGILEELEDVLLLLERFLPH
YFKGVLSIYKDPEHRKLGNMTVTVKKTVPSPEAVQILYQRMRYEYEFYHYVKEQFHLLKR
KFGLKSHVSKPPLRPHFFIPTPLETEEPIDDEEQDDEKWLEDIYKR

# Metabolic_Enzyme_28_Number_of_Residues:
406

# Metabolic_Enzyme_28_Molecular_Weight:
47674

# Metabolic_Enzyme_28_Theoretical_pI:
8.89

# Metabolic_Enzyme_28_GO_Classification:
Not Available

# Metabolic_Enzyme_28_General_Function:
Not Available

# Metabolic_Enzyme_28_Specific_Function:
Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin

# Metabolic_Enzyme_28_Pathway:
Not Available

# Metabolic_Enzyme_28_Reaction:
Not Available

# Metabolic_Enzyme_28_Pfam_Domain_Function:
PF05040:HS2ST

# Metabolic_Enzyme_28_Signals:
Not Available

# Metabolic_Enzyme_28_Transmembrane_Regions:
50-70

# Metabolic_Enzyme_28_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_28_EC_Link:
EC 2.8.2.-

# Metabolic_Enzyme_28_GenBank_ID_Protein:
4803735

# Metabolic_Enzyme_28_SwissProt_ID:
UST_HUMAN (Q9Y2C2)

# Metabolic_Enzyme_28_swissprot_Name:
Not Available

# Metabolic_Enzyme_28_Genecard_id:
UST

# Metabolic_Enzyme_28_Geneatlas_id:
UST

# Metabolic_Enzyme_28_hgnc_id:
HGNC:17223

# Metabolic_Enzyme_28_PDB_ID:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_28_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_28_Gene_Sequence:
>1221 bp
ATGAAGAAGAAGCAGCAGCATCCCGGCGGCGGCGCGGATCCCTGGCCCCATGGGGCCCCT
ATGGGGGGCGCCCCTCCGGGCCTGGGCAGCTGGAAGCGTCGGGTGCCCCTGCTGCCTTTC
CTGCGCTTCTCCCTCCGGGACTACGGCTTCTGCATGGCCACCCTGCTGGTCTTCTGCCTG
GGCTCCCTCCTCTATCAGCTCAGCGGGGGACCCCCTCGCTTCCTGCTCGACCTGCGGCAG
TACTTGGGAAATTCCACTTACTTGGATGACCATGGACCACCTCCTAGTAAGGTACTACCT
TTCCCAAGCCAGGTGGTGTACAACAGGGTAGGCAAGTGTGGGAGCCGTACTGTGGTCTTG
CTTCTGAGAATCTTGTCGGAGAAGCACGGATTTAATTTGGTCACATCAGACATTCACAAC
AAAACCAGGCTTACTAAAAATGAACAAATGGAACTGATTAAAAATATAAGTACTGCCGAA
CAACCCTATTTATTCACTCGACATGTTCATTTCCTCAACTTCTCAAGGTTTGGAGGAGAC
CAGCCTGTCTACATCAACATCATTAGAGACCCCGTCAACCGGTTCTTATCCAACTATTTT
TTCCGTCGCTTTGGAGACTGGAGAGGGGAACAAAATCACATGATCCGCACCCCCAGCATG
AGGCAGGAGGAGCGCTACCTGGATATCAATGAGTGTATTCTTGAAAACTATCCCGAGTGC
TCCAACCCCAGGTTATTTTACATCATTCCGTACTTTTGTGGACAGCATCCCAGATGCAGG
GAGCCTGGTGAATGGGCCCTTGAGAGAGCAAAGCTGAACGTGAATGAAAACTTCCTGCTC
GTGGGGATTCTTGAAGAGTTGGAAGATGTGCTGCTGTTACTGGAAAGATTTTTACCTCAT
TACTTCAAGGGCGTGCTCAGTATCTACAAAGACCCAGAGCACAGGAAGCTTGGAAACATG
ACTGTGACGGTGAAGAAGACTGTCCCCTCTCCTGAGGCTGTGCAGATCCTCTACCAGCGG
ATGAGATACGAGTACGAGTTTTACCACTACGTCAAAGAGCAGTTCCACCTGCTGAAGCGC
AAGTTTGGACTTAAGTCTCACGTCAGCAAGCCCCCCCTGAGGCCACACTTCTTTATCCCA
ACTCCACTGGAAACCGAGGAGCCAATCGACGATGAAGAACAGGATGATGAAAAGTGGCTG
GAAGATATTTATAAGAGGTGA

# Metabolic_Enzyme_28_GenBank_ID_Gene:
AB020316

# Metabolic_Enzyme_28_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_28_Locus:
6q25.1

# Metabolic_Enzyme_28_SNPs:
Not Available

# Metabolic_Enzyme_28_General_References:
10187838; 14574404

# Metabolic_Enzyme_28_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8511

# Macromolecular_Interacting_Partner_1_Name:
Heparan-sulfate 6-O-sulfotransferase 1

# Macromolecular_Interacting_Partner_1_Synonyms:
HS6ST-1

# Macromolecular_Interacting_Partner_1_Gene_Name:
HS6ST1

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Heparansulfate 6Osulfotransferase 1
MRRRRAGGRTMVERASKFVLVVAGSVCFMLILYQYAGPGLSLGAPGGRAPPDDLDLFPTP
DPHYEKKYYFPVRELERSLRFDMKGDDVIVFLHIQKTGGTTFGRHLVQNVRLEVPCDCRP
GQKKCTCYRPNRRETWLFSRFSTGWSCGLHADWTELTNCVPGVLDRRDSAALRTPRKFYY
ITLLRDPVSRYLSEWRHVQRGATWKTSLHMCDGRTPTPEELPPCYEGTDWSGCTLQEFMD
CPYNLANNRQVRMLADLSLVGCYNLSFIPEGKRAQLLLESAKKNLRGMAFFGLTEFQRKT
QYLFERTFNLKFIRPFMQYNSTRAGGVEVDEDTIRRIEELNDLDMQLYDYAKDLFQQRYQ
YKRQLERREQRLRSREERLLHRAKEALPREDADEPGRVPTEDYMSHIIEKW

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
411

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
48227

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
8.95

# Macromolecular_Interacting_Partner_1_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF06765:HS6ST

# Macromolecular_Interacting_Partner_1_Signals:
1-43

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
18-37

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
3073775

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
H6ST1_HUMAN (O60243)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
HS6ST1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
HS6ST1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:5201

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1233 bp
ATGCGGCGGCGGCCGCGCGGCAGGACCATGGTTGAGCGCGCCAGCAAGTTCGTGCTGGTG
GTGGCGGGCTCGGTGTGCTTCATGCTCATCTTGTACCAGTACGCGGGCCCAGGACTGAGC
CTGGGCGCGCCCGGCGGCCGCGCGCCGCCCGACGACCTGTACCTGTTCCCCACGCCCGAC
CCCCACTACGAGAAGAAGTACTACTTCCCGGTCCGCGAGCTGGAGCGCTCGCTGCGCTTC
GACATGAAGGGCGACGACGTGATCGTCTTCCTGCACATCCAGAAGACGGGCGGCACCACC
TTCGGCCGCCACCTCGTGCAGAACGTACGCCTCGAGGTGCCGTGCGACTGCCGGCCCGGC
CAGAAGAAGTGCACCTGCTACCGGCCCAACCGCCGCGAGACTTGGCTCTTCTCCCGCTTC
TCCACCGGCTGGAGCTGCGGGCTGCACGCCGACTGGACCGAGCTCACCAACTGCGTGCCC
GGCGTGCTGGACCGCCGCGACTCCGCCGCGCTGCGCACGCCCAGGAAGTTCTACTACATC
ACCCTGCTACGAGACCCCGTGTCCCGCTACCTGAGCGAGTGGCGGCATGTGCAGAGGGGT
GCCACGTGGAAGACGTCTTTGCATATGTGTGATGGGCGCACGCCCACGCCTGAGGAGCTG
CCGCCCTGCTACGAGGGCACGGACTGGTCGGGCTGCACGCTACAGGAGTTCATGGACTGC
CCGTACAACCTGGCCAACAACCGCCAGGTGCGCATGCTGGCCGACCTGAGCCTGGTGGGC
TGCTACAACCTGTCCTTCATCCCCGAGGGCAAGCGGGCCCAGCTGCTGCTCGAGAGCGCC
AAGAAGAACCTGCGGGGCATGGCCTTCTTCGGCCTGACCGAGTTCCAGCGCAAGACGCAG
TACCTGTTCGAGCGGACGTTCAACCTCAAGTTCATCCGGCCCTTCATGCAGTACAATAGC
ACGCGGGCGGGCGGCGTGGAGGTGGATGAAGACACCATCCGGCGCATCGAGGAGCTCAAC
GACCTGGACATGCAGCTGTACGACTACGCCAAGGACCTCTTCCAGCAGCGCTACCAGTAC
AAGCGGCAGCTGGAGCGCAGGGAGCAGCGCCTGAGGAGCCGCGAGGAGCGTCTGCTGCAC
CGGGCCAAGGAGGCACTGCCGCGGGAGGATGCCGACGAGCCGGGCCGCGTGCCCACCGAG
GACTACATGAGCCACATCATTGAGAAGTGGTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AB006179

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_1_Locus:
2q21

# Macromolecular_Interacting_Partner_1_SNPs:
rs1133923; rs840875; rs840871; rs2405747; rs999508; rs4662784; rs13386088; rs6723548; rs4662598; rs844484; rs7586881; rs6707476; rs12692077; rs6723230; rs6431009; rs4662786; rs12477083; rs6756336; rs840879; rs10183821; rs4662788; rs1375347; rs6707391; rs6431008; rs10928813; rs8179774; rs12469172; rs861461; rs840880; rs4662601; rs840887; rs6431005; rs6736450; rs8179791; rs840892; rs1530719; rs4662787; rs13428208; rs4662790; rs17794012; rs6431006; rs7595689; rs7566627; rs11885153; rs734193; rs10048789; rs4143782; rs840881; rs10202094; rs714129; rs4662791; rs4662789; rs4662794; rs6431007; rs13009437; rs6717511; rs8179790; rs840888; rs13403599; rs1375348; rs12469358; rs840870; rs7576120; rs4662599; rs12986656; rs17016070; rs13415049; rs840890; rs840874; rs4662785; rs17179479; rs12467100; rs12477751; rs7598684; rs840891; rs17793878; rs6745479; rs840889; rs17016134; rs840877; rs13384668; rs17016077; rs13412125; rs734192; rs13385412; rs17016059; rs4315469; rs13415346; rs1868393; rs17040155; rs9636238; rs1375349; rs6761320; rs12622112; rs6431010; rs7573453; rs7561107; rs7560767; rs17016102; rs13385717; rs12986686; rs13427836; rs6744014; rs12614331; rs17016137; rs10178365; rs2290113; rs3851895; rs840885; rs4625851; rs3991330; rs840886; rs2290114; rs3180466; rs4630712; rs7589803; rs4274545; rs3806472; rs11554551; rs1319882; rs840884; rs34511619; rs3958533; rs1055585; rs1055575; rs4082128; rs3916055; rs11554550; rs4662597; rs34310741; rs35040776; rs34162250; rs3844246; rs13385129; rs3851894; rs7587590; rs11267620; rs35261217; rs7574509; rs10170649; rs34974086; rs13392124; rs35533600; rs36053556; rs34957943; rs13010149; rs4662792; rs34427153; rs13000253; rs35374667; rs34273895; rs35648468; rs34284688; rs35176911; rs10175569; rs13387904; rs11884966; rs28595286; rs840872; rs35422391; rs840876; rs28521874; rs35442991; rs1540498; rs34724887; rs13422912; rs4662783; rs13014395; rs13014434; rs35313751; rs4662793; rs1540496; rs6711447; rs34794180; rs6742308; rs35260490; rs10209361; rs35042488; rs13401904; rs840894; rs35213695; rs5834203; rs13393462; rs13410048; rs33920058; rs13426089; rs1540497; rs35355231; rs840878; rs2122114; rs34778283; rs6712949; rs6713071; rs705050; rs13415473; rs840873; rs12994602; rs35168032; rs1992937; rs35473853; rs2084498; rs35978093; rs35227172; rs13019283; rs6708736; rs9636233; rs35609892; rs6738201; rs10206893; rs4662600; rs11461608; rs34200031; rs13424658; rs10445701; rs35711530; rs2405737; rs35860143; rs35145650; rs6759074; rs35138071; rs35882143; rs13422573; rs3851898; rs3042136; rs3863733; rs3991329; rs35261195; rs3844249; rs3851897; rs3844248; rs705051; rs3863732; rs2290115; rs4662596; rs13414064; rs3863731; rs4662595; rs4330066; rs34591025; rs904936; rs13389280; rs11554549; rs1043525; rs34658906; rs35062239; rs3844247; rs36105815; rs3820298; rs11444545; rs10177185; rs10189872; rs11689440; rs11690568; rs13034722; rs1868394; rs2305260; rs2579663; rs2595223; rs34800061; rs35428087; rs4416164; rs4429419; rs4662603; rs4662796; rs6728924; rs6733575; rs730816; rs840882; rs840883; rs840893; rs934919; rs934920; rs934921

# Macromolecular_Interacting_Partner_1_General_References:
9535912

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8540

# Macromolecular_Interacting_Partner_2_Name:
Carbohydrate sulfotransferase 2

# Macromolecular_Interacting_Partner_2_Synonyms:
N-acetylglucosamine 6-O- sulfotransferase 1; GlcNAc6ST-1; Gn6ST; Galactose/N- acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2; GST-2

# Macromolecular_Interacting_Partner_2_Gene_Name:
CHST2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Carbohydrate sulfotransferase 2
MSRSPQRALPPGALPRLLQAAPAAAPRALLPQWPRRPGRRWPASPLGMKVFRRKALVLCA
GYALLLVLTMLNLLDYKWHKEPLQQCNPDGPLGAAAGAAGGSWGRPGPPPAGPPRAHARL
DLRTPYRPPAAAVGAAPAAAAGMAGVAAPPGNGTRGTGGVGDKRQLVYVFTTWRSGSSFF
GELFNQNPEVFFLYEPVWHVWQKLYPGDAVSLQGAARDMLSALYRCDLSVFQLYSPAGSG
GRNLTTLGIFGAATNKVVCSSPLCPAYRKEVVGLVDDRVCKKCPPQRLARFEEECRKYRT
LVIKGVRVFDVAVLAPLLRDPALDLKVIHLVRDPRAVASSRIRSRHGLIRESLQVVRSRD
PRAHRMPFLEAAGHKLGAKKEGVGGPADYHALGAMEVICNSMAKTLQTALQPPDWLQGHY
LVVRYEDLVGDPVKTLRRVYDFVGLLVSPEMEQFALNMTSGSGSSSKPFVVSARNATQAA
NAWRTALTFQQIKQVEEFCYQPMAVLGYERVNSPEEVKDLSKTLLRKPRL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
530

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
57858

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
10.48

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Catalyzes the transfer of sulfate to position 6 of non- reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as L-selectin ligands. L-selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of L-selectin ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, nonreducing ends of oligosaccharide chains

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Macromolecular_Interacting_Partner_2_Signals:
Not Available

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
55-75

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
26801253

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
CHST2_HUMAN (Q9Y4C5)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
CHST2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
CHST2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:1970

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Golgi apparatus; trans-Golgi network; trans- Golgi network membrane; single-pass type II membrane protein (Probable)

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1452 bp
ATGAAGGTGTTCCGTAGGAAGGCGCTGGTGTTGTGCGCGGGCTATGCACTGCTGCTGGTG
CTCACTATGCTCAACCTCCTGGACTACAAGTGGCACAAGGAGCCGCTGCAGCAGTGCAAC
CCCGATGGGCCGCTGGGTGCCGCAGCGGGGGCAGCCGGAGGCAGCTGGGGGCGCCCAGGG
CCGCCTCCGGCCGGGCCGCCCCGTGCTCATGCCCGTTTGGACCTCCGCACTCCTTACCGC
CCTCCCGCTGCCGCCGTCGGGGCGGCTCCTGCAGCCGCGGCAGGGATGGCGGGGGTTGCG
GCCCCTCCAGGCAATGGCACTCGGGGCACCGGGGGCGTCGGGGACAAGCGGCAGCTGGTG
TACGTGTTCACCACGTGGCGCTCTGGCTCGTCGTTCTTCGGCGAGCTATTCAACCAGAAT
CCCGAGGTGTTCTTTCTCTACGAGCCAGTGTGGCATGTATGGCAAAAACTGTATCCGGGG
GACGCCGTTTCCCTGCAGGGGGCAGCGCGGGACATGCTGAGCGCTCTTTACCGCTGCGAC
CTCTCTGTCTTCCAGTTGTATAGCCCCGCGGGCAGCGGGGGGCGCAACCTCACCACGCTG
GGCATCTTCGGCGCAGCCACCAACAAGGTGGTGTGCTCGTCACCACTCTGCCCCGCCTAC
CGCAAGGAGGTCGTGGGGTTGGTGGACGACCGCGTGTGCAAGAAGTGCCCGCCACAGCGC
CTGGCGCGTTTCGAGGAGGAGTGCCGCAAGTACCGCACACTAGTCATAAAGGGTGTGCGC
GTCTTCGACGTGGCGGTCTTGGCGCCACTGCTGCGAGACCCGGCCCTGGACCTCAAGGTC
ATCCACTTGGTGCGTGATCCCCGCGCGGTGGCGAGTTCACGGATCCGCTCGCGCCACGGC
CTCATCCGTGAGAGCCTACAGGTGGTGCGCAGCCGAGACCCGCGAGCTCACCGCATGCCC
TTCTTGGAGGCCGCGGGCCACAAGCTTGGCGCCAAGAAGGAGGGCGTGGGCGGCCCCGCA
GACTACCACGCTCTGGGCGCTATGGAGGTCATCTGCAATAGTATGGCTAAGACGCTGCAG
ACAGCCCTGCAGCCCCCTGACTGGCTGCAGGGCCACTACCTGGTGGTGCGGTACGAGGAC
CTGGTGGGAGACCCCGTCAAGACACTACGGAGAGTGTACGATTTTGTGGGACTGTTGGTG
AGCCCCGAAATGGAGCAGTTTGCCCTGAACATGACCAGTGGCTCGGGCTCCTCCTCCAAG
CCTTTCGTGGTATCTGCACGCAATGCCACGCAGGCCGCCAATGCCTGGCGGACCGCCCTC
ACCTTCCAGCAGATCAAACAGGTGGAGGAGTTTTGCTACCAGCCCATGGCCGTCCTGGGC
TATGAGCGGGTCAACAGCCCTGAGGAGGTCAAAGACCTCAGCAAGACCCTGCTTCGGAAG
CCCCGTCTCTAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AB014679

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_2_Locus:
3q24

# Macromolecular_Interacting_Partner_2_SNPs:
rs4149494; rs6664; rs2280083; rs4149495; rs4149496; rs4683739; rs3755740; rs3755739; rs1801847; rs11549674; rs1473870; rs12486551; rs12489877; rs6764683; rs3755738; rs1056360; rs11707027; rs11718140; rs11919563; rs13070425; rs13322379; rs13322528; rs16852993; rs16852995; rs16853017; rs2292508; rs2292509; rs34085538; rs3755741; rs3898303; rs4082145; rs4491864; rs4683448; rs4683449; rs4683450; rs4683451; rs4683452; rs4683453; rs4683737; rs4683738; rs6767018; rs6770489; rs6779586; rs6780752; rs6794836; rs6801537; rs6801610; rs7611217; rs7640077

# Macromolecular_Interacting_Partner_2_General_References:
9722682; 10049591; 11042394; 11310842

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8609

# Macromolecular_Interacting_Partner_3_Name:
Heparan-sulfate 6-O-sulfotransferase 2

# Macromolecular_Interacting_Partner_3_Synonyms:
HS6ST-2

# Macromolecular_Interacting_Partner_3_Gene_Name:
HS6ST2

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Heparansulfate 6Osulfotransferase 2
MALPACAVREFEPPRQPERGAPVRTTCPRRHSRVEAELAASRPGSVAASVRAGPPRGVSH
GFHTRPLLDKPRKASSSLAGAACAPLFALLSRGRRRRMHVLRRRWDLGSLCRALLTRGLA
ALGHSLKHVLGAIFSKIFGPMASVGNMDEKSNKLLLALVMLFLFAVIVLQYVCPGTECQL
LRLQAFSSPVPDPYRSEDESSARFVPRYNFTRGDLLRKVDFDIKGDDLIVFLHIQKTGGT
TFGRHLVRNIQLEQPCECRVGQKKCTCHRPGKRETWLFSRFSTGWSCGLHADWTELTSCV
PSVVDGKRDARLRPSRNFHYITILRDPVSRYLSEWRHVQRGATWKASLHVCDGRPPTSEE
LPSCYTGDDWSGCPLKEFMDCPYNLANNRQVRMLSDLTLVGCYNLSVMPEKQRNKVLLES
AKSNLKHMAFFGLTEFQRKTQYLFEKTFNMNFISPFTQYNTTRASSVEINEEIQKRIEGL
NFLDMELYSYAKDLFLQRYQFMRQKEHQEARRKRQEQRKFLKGRLLQTHFQSQGQGQSQN
PNQNQSQNPNPNANQNLTQNLMQNLTQSLSQKENRESPKQNSGKEQNDNTSNGTNDYIGS
VEKWR

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
605

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
69131

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
10.25

# Macromolecular_Interacting_Partner_3_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF06765:HS6ST

# Macromolecular_Interacting_Partner_3_Signals:
1-178

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
5-27

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
22122070

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
H6ST2_HUMAN (Q96MM7)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
HS6ST2

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
HS6ST2

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:19133

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1500 bp
ATGGATGAGAAATCCAACAAGCTGCTGCTAGCTTTGGTGATGCTCTTCCTATTTGCCGTG
ATCGTCCTCCAATACGTGTGCCCCGGCACAGAATGCCAGCTCCTCCGCCTGCAGGCGTTC
AGCTCCCCGGTGCCGGACCCGTACCGCTCGGAGGATGAGAGCTCCGCCAGGTTCGTGCCC
CGCTACAATTTCACCCGCGGCGACCTCCTGCGCAAGGTAGACTTCGACATCAAGGGCGAT
GACCTGATCGTGTTCCTGCACATCCAGAAGACCGGGGGCACCACTTTCGGCCGCCACTTG
GTGCGTAACATCCAGCTGGAGCAGCCGTGCGAGTGCCGCGTGGGTCAGAAGAAATGCACT
TGCCACCGGCCGGGTAAGCGGGAAACCTGGCTCTTCTCCAGGTTCTCCACGGGCTGGAGC
TGCGGGTTGCACGCCGACTGGACCGAGCTCACCAGCTGTGTGCCCTCCGTGGTGGACGGC
AAGCGCGACGCCAGGCTGAGACCGTCCAGGTGGAGGATTTTTCAGATTCTAGATGCAGCA
AGTAAGGATAAACGGGGTTCTCCAAACACTAACGCAGGCGCCAACTCTCCGTCATCCACA
AAGACCCGGAACACATCTAAGAGTGGGAAGAACTTCCACTACATCACCATCCTCCGAGAC
CCAGTGTCCCGGTACTTGAGTGAGTGGAGGCATGTCCAGAGAGGGGCAACATGGAAAGCA
TCCCTGCATGTCTGCGATGGAAGGCCTCCAACCTCCGAAGAGCTGCCCAGCTGCTACACT
GGCGATGACTGGTCTGGCTGCCCCCTCAAAGAGTTTATGGACTGTCCCTACAATCTAGCC
AACAACCGCCAGGTGCGCATGCTCTCCGACCTGACCCTGGTAGGCTGCTACAACCTCTCT
GTCATGCCTGAAAAGCAAAGAAACAAGGTCCTTCTGGAAAGTGCCAAGTCAAATCTGAAG
CACATGGCGTTCTTCGGCCTCACTGAGTTTCAGCGGAAGACCCAATATCTGTTTGAGAAA
ACCTTCAACATGAACTTTATTTCGCCATTTACCCAGTATAATACCACTAGGGCCTCTAGT
GTAGAGATCAATGAGGAAATTCAAAAGCGTATTGAGGGACTGAATTTTCTGGATATGGAG
TTGTACAGCTATGCCAAAGACCTTTTTTTGCAGAGGTATCAGTTTATGAGGCAGAAAGAG
CATCAGGAGGCCAGGCGAAAGCGTCAGGAACAACGCAAATTTCTGAAGGGAAGGCTCCTT
CAGACCCATTTCCAGAGCCAGGGTCAGGGCCAGAGCCAGAATCCGAATCAGAATCAGAGT
CAGAACCCAAATCCGAATGCCAATCAGAACCTGACTCAGAATCTGATGCAGAATCTGACT
CAGAGTTTGAGCCAGAAGGAGAACCGGGAAAGCCCGAAGCAGAACTCAGGCAAGGAGCAG
AATGATAACACCAGCAATGGCACCAACGACTACATAGGCAGTGTAGAGAAATGGCGTTAA


# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AB067776

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_3_Locus:
Xq26.2

# Macromolecular_Interacting_Partner_3_SNPs:
rs243463; rs243462; rs5933172; rs5933243; rs243464; rs243442; rs243470; rs243466; rs988532; rs1034424; rs1005580; rs1894563; rs5977751; rs4829746; rs5977743; rs7065851; rs2227084; rs243468; rs5977778; rs5975354; rs5977730; rs5930584; rs243444; rs1041891; rs864538; rs5930591; rs5977761; rs4830249; rs4381115; rs5977777; rs243476; rs6654650; rs7881124; rs4830252; rs5933185; rs4829744; rs5933220; rs5975355; rs5977738; rs5933209; rs243449; rs5930583; rs7884330; rs5977755; rs243438; rs11096342; rs4462057; rs5933228; rs858616; rs17390; rs5933186; rs5933219; rs5933179; rs5933233; rs743804; rs7878461; rs243439; rs243446; rs243450; rs5977779; rs5930582; rs5933205; rs2227083; rs10482420; rs1263062; rs5933229; rs5933222; rs4830254; rs5977746; rs707250; rs5977762; rs5933181; rs5975347; rs12014965; rs5933204; rs5930592; rs5977775; rs1155954; rs5977759; rs5977748; rs1547417; rs6638022; rs929061; rs17379; rs2315524; rs5977736; rs5977786; rs5975360; rs5977770; rs7050404; rs858622; rs10521777; rs858618; rs5977765; rs5975357; rs12392638; rs858621; rs7883421; rs1540302; rs7065585; rs5933227; rs243465; rs2227141; rs5930577; rs5933211; rs1849202; rs7054155; rs12558802; rs2097381; rs11798681; rs7877499; rs5933202; rs858620; rs5933192; rs243451; rs243447; rs858615; rs5977769; rs4830248; rs5977754; rs5933183; rs12688563; rs5933212; rs183103; rs5977753; rs243467; rs7884763; rs5933215; rs6654657; rs7065607; rs5933216; rs5977737; rs7885329; rs243469; rs1511739; rs17317147; rs5933178; rs5977766; rs243441; rs5975362; rs5977785; rs243440; rs12689919; rs7061986; rs1540301; rs5977757; rs6638037; rs5933241; rs2187831; rs17000283; rs5933230; rs5975352; rs243443; rs17251211; rs17277489; rs12393670; rs17000306; rs5933203; rs2064118; rs5933198; rs7892161; rs5933223; rs6654268; rs243455; rs11795684; rs5933210; rs17324091; rs11798632; rs5975364; rs17251232; rs5977783; rs12395504; rs7058203; rs1009402; rs5933200; rs5933214; rs12014442; rs11096346; rs17000319; rs1818434; rs11096353; rs7884165; rs12012947; rs12383670; rs5933240; rs858619; rs189646; rs5933218; rs12010277; rs5930574; rs17391; rs12007214; rs5977784; rs5975363; rs17317084; rs12558244; rs5933199; rs12844906; rs5933189; rs5977749; rs5975351; rs17324216; rs17000325; rs7055167; rs5977763; rs5930589; rs5977724; rs7883299; rs17317077; rs10449086; rs11796112; rs7883862; rs13441091; rs5933184; rs5975361; rs5977768; rs16993003; rs7357884; rs11096351; rs12560188; rs11799044; rs6654653; rs6638027; rs5930578; rs592; rs1008182; rs5933237; rs243448; rs17000367; rs5933195; rs5933187; rs7050638; rs5933197; rs5977732; rs7887600; rs1270624; rs7057304; rs5930580; rs996457; rs5933232; rs7066057; rs5930579; rs11096349; rs7878720; rs10482419; rs7880694; rs12558253; rs5933213; rs6654649; rs12688037; rs5933208; rs5930581; rs7052715; rs6638026; rs10126486; rs5930575; rs7878472; rs5933194; rs243454; rs41300279; rs34647867; rs36208458; rs10482422; rs34069927; rs5977721; rs41300281; rs34948227; rs11398839; rs11392911; rs36120934; rs35356317; rs11392910; rs5933206; rs2858963; rs4830255; rs1114801; rs2668035; rs34138512; rs28792392; rs13440626; rs12016525; rs5933217; rs5933196; rs34487478; rs6638015; rs34051913; rs12856738; rs5933235; rs28526521; rs35485258; rs34611328; rs10592129; rs36102287; rs28657970; rs34090467; rs12856911; rs34465223; rs34113762; rs34908121; rs34816177; rs11415697; rs5977731; rs5977787; rs34661377; rs34063982; rs5933177; rs12851004; rs5977780; rs11267104; rs10442500; rs34789788; rs34934387; rs12393812; rs35530149; rs34694310; rs6634910; rs35463766; rs5977726; rs34392947; rs34480929; rs35914789; rs7886210; rs17380; rs12840043; rs34911862; rs5977756; rs12838022; rs6638036; rs4830250; rs35292964; rs35530278; rs5903833; rs12836237; rs11439034; rs5903835; rs4360448; rs12839805; rs6638025; rs5933207; rs35437683; rs12012657; rs5903842; rs34014302; rs1011510; rs36028236; rs34466408; rs7886130; rs34335021; rs6418952; rs34596880; rs34635456; rs12388441; rs34224371; rs35709493; rs3033787; rs17000323; rs12392678; rs35316060; rs35972206; rs5975350; rs5933182; rs12850502; rs5933239; rs28482362; rs5977735; rs12862113; rs858617; rs5005814; rs12397898; rs35537466; rs34555257; rs5975348; rs28665573; rs35299521; rs35630558; rs28696978; rs858614; rs34349908; rs36110669; rs7053390; rs10599070; rs34136355; rs12849834; rs35404347; rs5975349; rs5933234; rs5977772; rs5975358; rs34948988; rs7357976; rs34310863; rs2858965; rs11341534; rs10700617; rs35990068; rs12389066; rs10545986; rs28676982; rs34945360; rs12861686; rs12837453; rs35827625; rs6654269; rs17000311; rs6638016; rs35743008; rs33928536; rs10449072; rs7883556; rs5977750; rs34986193; rs10680956; rs9699120; rs12395155; rs6638031; rs5977725; rs10127410; rs4829747; rs34481887; rs7473635; rs5903841; rs10218243; rs34729454; rs12007260; rs34131398; rs3066707; rs5933224; rs5977764; rs11342314; rs36038119; rs5933238; rs34878834; rs5930585; rs5005813; rs762946; rs6634909; rs5903843; rs35645385; rs36112933; rs34959737; rs12862276; rs33985928; rs12860403; rs34900289; rs33998942; rs35115789; rs35883256; rs762947; rs35493476; rs4830251; rs7057178; rs7059199; rs12013153; rs12858554; rs34902965; rs34006747; rs2213462; rs34209607; rs12837490; rs5977729; rs12836238; rs28568783; rs2858961; rs35475942; rs7055609; rs34861375; rs12838485; rs5977773; rs190269; rs12838260; rs35139340; rs6638039; rs11797975; rs12834634; rs11422742; rs11331815; rs7065710; rs34340839; rs7061951; rs35218456; rs6638040; rs34294888; rs35239612; rs35055703; rs5977744; rs34777508; rs12849718; rs6638019; rs5977781; rs6634905; rs6638029; rs3065679; rs12007269; rs5903836; rs11377073; rs35616651; rs35992581; rs28631607; rs11408100; rs35977001; rs35040570; rs5977782; rs35511161; rs35365240; rs189645; rs28642826; rs33918505; rs6638028; rs5933180; rs35511274; rs5933221; rs10665237; rs35453506; rs2872879; rs33948590; rs34397892; rs34568584; rs13441149; rs12842156; rs5903838; rs5903844; rs1540309; rs28785001; rs13440709; rs34860051; rs35370060; rs5977760; rs34616335; rs5977745; rs34437970; rs12842512; rs7878947; rs34040341; rs7357979; rs34493900; rs12863277; rs5933201; rs10683998; rs762948; rs35661018; rs35595996; rs35259496; rs28583461; rs35479527; rs2227082; rs10550199; rs10547358; rs243445; rs7053397; rs12846986; rs5930593; rs35273822; rs7050068; rs11284685; rs7058765; rs4996856; rs34195544; rs5977776; rs35669627; rs5977739; rs12840953; rs12847998; rs2213461; rs5933225; rs12841276; rs34234098; rs35840603; rs17000315; rs34070174; rs17000317; rs34824160; rs34793652; rs12391652; rs34008866; rs4348643; rs5977741; rs41304516; rs6638021; rs28571201; rs5903837; rs35910101; rs34153760; rs2858960; rs7884671; rs4829745; rs34330084; rs7062452; rs12016025; rs5977734; rs28447062; rs6638017; rs5977728; rs5933242; rs34085703; rs5933193; rs11408551; rs12849431; rs7889395; rs34960975; rs11348383; rs12863265; rs7473791; rs5977727; rs4140647; rs34813821; rs12863387; rs34858574; rs12853850; rs28734077; rs5977723; rs6638018; rs12394189; rs2046; rs5903839; rs12390022; rs5977722; rs4469631; rs12858184; rs10538975; rs5977774; rs7054669; rs3033785; rs35044894; rs12853809; rs34919212; rs12862610; rs5930587; rs34469823; rs1573696; rs4440768; rs5975356; rs9782051; rs5903834; rs11325587; rs12862138; rs34230779; rs7885744; rs6654267; rs34333008; rs7065706; rs7059123; rs34380029; rs11296867; rs2213463; rs12833554; rs35495092; rs6638013; rs34028992; rs35664081; rs5903832; rs36006396; rs6638023; rs35783156; rs863954; rs28587746; rs6634912; rs2839992; rs12013065; rs34800516; rs4634804; rs1988860; rs2315336; rs5933231; rs34863636; rs12392625; rs6638014; rs12837376; rs5977747; rs5933226; rs5977742; rs2668034; rs12834401; rs6654272; rs35200414; rs7065870; rs34640492; rs34721277; rs5977767; rs34899532; rs743805; rs5975365; rs35932453; rs6634907; rs34590782; rs5933236; rs34479635; rs5903840; rs10482421; rs34918400; rs34931565; rs10647329; rs4830253; rs10693295; rs7357977; rs36054867; rs2012520; rs12861693; rs7060267; rs34108520; rs12838432; rs12834755; rs35617435; rs35933072; rs5977771; rs11797329; rs34119083; rs12843251; rs7357980; rs5933244; rs5975346; rs6638043; rs12841883; rs5977790; rs11096340; rs11797355; rs12392851; rs12558698; rs1511740; rs151774; rs151775; rs17000273; rs2227063; rs242914; rs243452; rs243472; rs243473; rs4573443; rs5933245; rs6638012; rs6654266; rs7053673; rs7060773; rs7888326; rs860834; rs997945

# Macromolecular_Interacting_Partner_3_General_References:
Not Available

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8752

# Macromolecular_Interacting_Partner_4_Name:
Carbohydrate sulfotransferase 4

# Macromolecular_Interacting_Partner_4_Synonyms:
N-acetylglucosamine 6-O- sulfotransferase 2; GlcNAc6ST-2; High endothelial cells N- acetylglucosamine 6-O-sulfotransferase; HEC-GlcNAc6ST; L-selectin ligand sulfotransferase; LSST; Galactose/N-acetylglucosamine/N- acetylglucosamine 6-O-sulfotransferase 3; GST-3

# Macromolecular_Interacting_Partner_4_Gene_Name:
CHST4

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Carbohydrate sulfotransferase 4
MLLPKKMKLLLFLVSQMAILALFFHMYSHNISSLSMKAQPERMHVLVLSSWRSGSSFVGQ
LFGQHPDVFYLMEPAWHVWMTFKQSTAWMLHMAVRDLIRAVFLCDMSVFDAYMEPGPRRQ
SSLFQWENSRALCSAPACDIIPQDEIIPRAHCRLLCSQQPFEVVEKACRSYSHVVLKEVR
FFNLQSLYPLLKDPSLNLHIVHLVRDPRAVFRSRERTKGDLMIDSRIVMGQHEQKLKKED
QPYYVMQVICQSQLEIYKTIQSLPKALQERYLLVRYEDLARAPVAQTSRMYEFVGLEFLP
HLQTWVHNITRGKGMGDHAFHTNARDALNVSQAWRWSLPYEKVSRLQKACGDAMNLLGYR
HVRSEQEQRNLLLDLLSTWTVPEQIH

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
386

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
45134

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
9.15

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Catalyzes the transfer of sulfate to position 6 of non- reducing N-acetylglucosamine (GlcNAc) residues within mucin- associated glycans that ultimately serve as L-selectin ligands. L- selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of L-selectin ligand sialyl 6-sulfo Lewis X on L-selectin counter receptors CD43, GlyCAM-1 and MAdCAM- 1. Also involved in biosynthesis of L-selectin ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2-branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1-3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Macromolecular_Interacting_Partner_4_Signals:
1-21

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
8-28

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
4927114

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
CHST4_HUMAN (Q8NCG5)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
CHST4

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
CHST4

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:1972

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1161 bp
ATGCTACTGCCTAAAAAAATGAAGCTCCTGCTGTTTCTGGTTTCCCAGATGGCCATCTTG
GCTCTATTCTTCCACATGTACAGCCACAACATCAGCTCCCTGTCTATGAAGGCACAGCCC
GAGCGCATGCACGTGCTGGTTCTGTCTTCCTGGCGCTCTGGCTCTTCTTTTGTGGGGCAG
CTTTTTGGGCAGCACCCAGATGTTTTCTACCTGATGGAGCCCGCCTGGCACGTGTGGATG
ACCTTCAAGCAGAGCACCGCCTGGATGCTGCACATGGCTGTGCGGGATCTGATACGGGCC
GTCTTCTTGTGCGACATGAGCGTCTTTGATGCCTACATGGAACCTGGTCCCCGGAGACAG
TCCAGCCTCTTTCAGTGGGAGAACAGCCGGGCCCTGTGTTCTGCACCTGCCTGTGACATC
ATCCCACAAGATGAAATCATCCCCCGGGCTCACTGCAGGCTCCTGTGCAGTCAACAGCCC
TTTGAGGTGGTGGAGAAGGCCTGCCGCTCCTACAGCCACGTGGTGCTCAAGGAGGTGCGC
TTCTTCAACCTGCAGTCCCTCTACCCGCTGCTGAAAGACCCCTCCCTCAACCTGCATATC
GTGCACCTGGTCCGGGACCCCCGGGCCGTGTTCCGTTCCCGAGAACGCACAAAGGGAGAT
CTCATGATTGACAGTCGCATTGTGATGGGGCAGCATGAGCAGAAACTCAAGAAGGAGGAC
CAACCCTACTATGTGATGCAGGTCATCTGCCAAAGCCAGCTGGAGATCTACAAGACCATC
CAGTCCTTGCCCAAGGCCCTGCAGGAACGCTACCTGCTTGTGCGCTATGAGGACCTGGCT
CGAGCCCCTGTGGCCCAGACTTCCCGAATGTATGAATTCGTGGGATTGGAATTCTTGCCC
CATCTTCAGACCTGGGTGCATAACATCACCCGAGGCAAGGGCATGGGTGACCACGCTTTC
CACACAAATGCCAGGGATGCCCTTAATGTCTCCCAGGCTTGGCGCTGGTCTTTGCCCTAT
GAAAAGGTTTCTCGACTTCAGAAAGCCTGTGGCGATGCCATGAATTTGCTGGGCTACCGC
CACGTCAGATCTGAACAAGAACAGAGAAACCTGTTGCTGGATCTTCTGTCTACCTGGACT
GTCCCTGAGCAAATCCACTAA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
AF131235

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_4_Locus:
16q22.3

# Macromolecular_Interacting_Partner_4_SNPs:
rs12935725; rs8060844; rs8061078; rs9926110; rs16973292; rs4149499; rs4297683; rs16943790; rs8061512; rs8044068; rs2004672; rs4584826; rs4149497; rs4149498; rs3813744; rs11315850; rs36035390; rs28574932; rs35909376; rs9746245; rs34582688; rs9938349; rs4788806; rs11299179; rs7191509; rs34969554; rs9745501; rs12931411; rs7201189; rs10500558; rs11640165; rs11859304; rs11863967; rs11864464; rs12919417; rs13333985; rs16973284; rs16973286; rs16973288; rs16973322; rs310334; rs310335; rs35986945; rs7194638; rs8044561; rs9935288

# Macromolecular_Interacting_Partner_4_General_References:
10330415; 11439191; 11181564; 11310842

# Macromolecular_Interacting_Partner_4_References:
Not Available

# Macromolecular_Interacting_Partner_5_ID:
8811

# Macromolecular_Interacting_Partner_5_Name:
Carbohydrate sulfotransferase 5

# Macromolecular_Interacting_Partner_5_Synonyms:
N-acetylglucosamine 6-O- sulfotransferase 3; GlcNAc6ST-3; Intestinal GlcNAc-6- sulfotransferase; Intestinal N-acetylglucosamine-6-O- sulfotransferase; I-GlcNAc6ST; hIGn6ST; Galactose/N- acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha; GST4-alpha

# Macromolecular_Interacting_Partner_5_Gene_Name:
CHST5

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Carbohydrate sulfotransferase 5
MWLPRFSSKTVTVLLLAQTTCLLLFIISRPGPSSPAGGEDRVHVLVLSSWRSGSSFLGQL
FSQHPDVFYLMEPAWHVWTTLSQGSAATLHMAVRDLMRSIFLCDMDVFDAYMPQSRNLSA
FFNWATSRALCSPPACSAFPRGTISKQDVCKTLCTRQPFSLAREACRSYSHVVLKEVRFF
NLQVLYPLLSDPALNLRIVHLVRDPRAVLRSREAAGPILARDNGIVLGTNGKWVEADPHL
RLIREVCRSHVRIAEAATLKPPPFLRGRYRLVRFEDLAREPLAEIRALYAFTGLTLTPQL
EAWIHNITHGSGIGKPIEAFHTSSRNARNVSQAWRHALPFTKILRVQEVCAGALQLLGYR
PVYSADQQRDLTLDLVLPRGPDHFSWASPD

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
390

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
43833

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
9.80

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Catalyzes the transfer of sulfate to position 6 of non- reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the nonreducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N- acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for L-selectin. Its substrate specificity may be influenced by its subcellular location

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Macromolecular_Interacting_Partner_5_Signals:
1-33

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
10-27

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
5917706

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
CHST5_HUMAN (Q9GZS9)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
CHST5

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
CHST5

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:1973

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Probable). Note=Golgi membrane, early secretory pathway

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1173 bp
ATGTGGCTGCCACGGTTCTCCAGCAAGACAGTGACAGTGCTCCTCCTGGCACAGACCACC
TGCCTCCTGCTCTTCATCATCTCCCGGCCAGGGCCCTCATCCCCAGCCGGCGGCGAGGAT
CGTGTGCACGTGCTGGTGCTGTCCTCGTGGCGCTCGGGCTCATCCTTCTTGGGCCAGCTC
TTCAGCCAGCACCCCGACGTCTTCTACCTGATGGAGCCCGCGTGGCATGTGTGGACCACC
CTGTCGCAGGGCAGCGCGGCAACGCTGCACATGGCCGTGCGCGACCTGATGCGCTCTATC
TTTTTGTGCGACATGGACGTGTTTGATGCCTACATGCCACAGAGCCGAAACCTGTCCGCC
TTTTTCAACTGGGCAACGAGCCGCGCGCTGTGCTCGCCGCCCGCCTGCAGCGCCTTTCCC
CGAGGCACCATCAGCAAGCAGGACGTATGCAAGACACTGTGCACGCGGCAGCCATTCAGC
CTGGCCCGGGAGGCCTGCCGCTCCTACAGCCACGTGGTGCTCAAGGAGGTGCGCTTCTTC
AACCTGCAGGTGCTCTACCCGCTGCTCAGCGACCCCGCGCTCAACCTGCGCATCGTGCAC
CTGGTGCGCGACCCGCGGGCCGTGCTGCGCTCCCGGGAGGCGGCGGGCCCGATACTGGCA
CGCGACAACGGCATCGTGCTGGGCACCAACGGCAAGTGGGTGGAGGCCGACCCTCACCTG
CGCCTGATTCGCGAGGTGTGCCGCAGCCACGTGCGCATCGCCGAGGCCGCCACACTCAAG
CCGCCACCCTTCCTGCGCGGCCGCTACCGCCTGGTGCGCTTCGAGGACCTGGCGCGGGAG
CCGCTGGCAGAGATCCGCGCACTCTACGCCTTCACCGGCCTGACCCTCACGCCACAGCTC
GAGGCCTGGATCCACAACATCACCCACGGGTCGGGGATCGGCAAGCCAATCGAGGCCTTC
CATACTTCGTCTAGGAATGCGCGCAACGTCTCCCAGGCCTGGCGCCACGCGTTGCCCTTC
ACTAAGATCCTGCGCGTGCAGGAGGTGTGCGCCGGCGCGCTGCAGCTGCTGGGCTACCGG
CCTGTGTACTCTGCGGACCAGCAGCGTGACCTCACCCTGGATCTGGTGCTGCCACGAGGC
CCAGACCACTTCAGCTGGGCATCGCCTGACTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AF176838

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_5_Locus:
16q22.3

# Macromolecular_Interacting_Partner_5_SNPs:
rs3826107; rs8048818; rs394150; rs2242407; rs2550913; rs2550911; rs2641801; rs2641805; rs7199936; rs2641804; rs2641806; rs3784932; rs2550886; rs2550887; rs2641800; rs2550912; rs3784934; rs4149501; rs2650396; rs2738790; rs448629; rs2738808; rs6564264; rs2738789; rs2738819; rs2550910; rs2738816; rs415387; rs11861541; rs2738818; rs4149504; rs2738792; rs379929; rs2242406; rs8059577; rs11864368; rs2641803; rs2550888; rs4149500; rs3736377; rs7202717; rs3826108; rs1690507; rs414304; rs2650399; rs1127396; rs1690506; rs8062862; rs2453141; rs2242408; rs17606758; rs2550915; rs2641799; rs723694; rs6564265; rs2641809; rs8055668; rs2550909; rs2738793; rs2738796; rs11149840; rs2937026; rs7206332; rs383400; rs2937027; rs2550889; rs2432619; rs2572091; rs2641802; rs11458265; rs35767878; rs2550884; rs2738791; rs2738801; rs15957; rs35148864; rs28627910; rs1043661; rs2650397; rs2738802; rs2650398; rs2572092; rs34494540; rs34126342; rs2550883; rs2738817; rs2572093; rs364062; rs11458612; rs16975622; rs11348291; rs2550914; rs35062691; rs1690505; rs13332796; rs11149839; rs2472199; rs35152637; rs11277312; rs2017265; rs2550885; rs8051800; rs10673726; rs388223; rs7189782; rs34351636; rs35209805; rs2572090; rs34596173; rs8058586; rs11645304; rs8046531; rs3103964; rs11648942; rs28829596; rs1166205; rs1166206; rs12149103; rs12595883; rs12598751; rs2738794; rs3851741; rs3896549; rs8046977; rs8057684; rs8061183

# Macromolecular_Interacting_Partner_5_General_References:
10491328; 11017086

# Macromolecular_Interacting_Partner_5_References:
Not Available

# Macromolecular_Interacting_Partner_6_ID:
8880

# Macromolecular_Interacting_Partner_6_Name:
Heparan-sulfate 6-O-sulfotransferase 3

# Macromolecular_Interacting_Partner_6_Synonyms:
HS6ST-3

# Macromolecular_Interacting_Partner_6_Gene_Name:
HS6ST3

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Heparansulfate 6Osulfotransferase 3
MDERFNKWLLTPVLTLLFVVIMYQYVSPSCTSSCTNFGEQPRAGEAGPPAVPGPARRAQA
PPEEWERRPQLPPPPRGPPEGPRGAAAPEEEDEEPGDPREGEEEEEEDEPDPEAPENGSL
PRFVPRFNFSLKDLTRFVDFNIKGRDVIVFLHIQKTGGTTFGRHLVKNIRLEQPCSCKAG
QKKCTCHRPGKKETWLFSRFSTGWSCGLHADWTELTNCVPAIMEKKDCPRNHSHTRNFYY
ITMLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFMD
CTYNLANNRQVRMLADLSLVGCYNLTFMNESERNTILLQSAKNNLKNMAFFGLTEFQRKT
QFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRYH
HTKQLEHQRDRQKRREERRLQREHRDHQWPKEDGAAEGTVTEDYNSQVVRW

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
471

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
54844

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
6.82

# Macromolecular_Interacting_Partner_6_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF06765:HS6ST

# Macromolecular_Interacting_Partner_6_Signals:
1-28

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
5-27

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
H6ST3_HUMAN (Q8IZP7)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
HS6ST3

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
HS6ST3

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:19134

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
AF539426

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:13

# Macromolecular_Interacting_Partner_6_Locus:
13q32.1

# Macromolecular_Interacting_Partner_6_SNPs:
rs9516771; rs2282135; rs3864; rs2282136; rs3742123; rs10492534; rs4771259; rs7337667; rs7318501; rs11842413; rs913427; rs1410266; rs2389662; rs2389528; rs912691; rs1327634; rs573909; rs1932500; rs1924588; rs1927789; rs979231; rs1927790; rs1925133; rs1924595; rs2389630; rs1925110; rs1925121; rs601674; rs1924578; rs971604; rs1927808; rs1927548; rs523268; rs816109; rs2849439; rs1887473; rs1927792; rs2389663; rs517984; rs993757; rs912690; rs2147688; rs386042; rs1925132; rs2389668; rs1328049; rs1998698; rs1327919; rs1927793; rs1887599; rs1927809; rs1410343; rs1010345; rs1328054; rs413516; rs1012975; rs1925112; rs1164597; rs1164591; rs1925115; rs912692; rs2261183; rs1925128; rs503466; rs1925118; rs1925098; rs2257398; rs529060; rs1927794; rs1164586; rs1927807; rs1410339; rs1887600; rs1328051; rs1924590; rs1930221; rs2149314; rs1925134; rs1927796; rs1336101; rs9302098; rs7325688; rs1930224; rs4328305; rs11069244; rs7329346; rs1577606; rs9525147; rs1925106; rs583038; rs9525154; rs1328052; rs9590370; rs7985691; rs6492842; rs9516640; rs8000284; rs1886560; rs2057575; rs719200; rs431500; rs7331513; rs1927791; rs9516667; rs9525143; rs9556589; rs1022898; rs9556593; rs1305330; rs4771951; rs4771946; rs7982552; rs2147687; rs1160200; rs7985299; rs4771252; rs472010; rs9525141; rs4773947; rs557204; rs6491285; rs7324153; rs3892845; rs7331257; rs9556528; rs1925116; rs7324569; rs9300365; rs7324785; rs7992668; rs9300341; rs9556603; rs9302097; rs1359857; rs7995859; rs1327916; rs9525166; rs4771950; rs3956457; rs4771934; rs622143; rs1925119; rs764574; rs2257397; rs4771258; rs9516670; rs1924596; rs7984912; rs986969; rs7993600; rs9582066; rs7339344; rs9516682; rs7322776; rs417259; rs9556578; rs4771952; rs6491307; rs1925120; rs7988675; rs7319073; rs1164592; rs1164598; rs1889860; rs1328058; rs7323332; rs7981845; rs927709; rs7329425; rs7328389; rs4773938; rs4142574; rs943824; rs7317433; rs9525158; rs4773941; rs640946; rs9513122; rs4771251; rs7992274; rs7324999; rs1925104; rs913428; rs9300344; rs6492836; rs1327914; rs1930222; rs912697; rs9516686; rs8001839; rs2768777; rs9525156; rs1410106; rs4773948; rs4771948; rs3901859; rs3848007; rs4771929; rs7334014; rs526381; rs9516690; rs639527; rs7325236; rs1925108; rs384431; rs542834; rs7338171; rs1328055; rs7338412; rs7331050; rs9525134; rs7337702; rs9516642; rs943560; rs506849; rs9516704; rs4278609; rs12428610; rs7984507; rs9300346; rs4142189; rs9525160; rs12431279; rs4111147; rs1475296; rs9556587; rs9516655; rs9300357; rs1925103; rs7321255; rs9302095; rs872634; rs6491306; rs8001097; rs7491529; rs9516648; rs9562050; rs9562045; rs6491290; rs7987510; rs506757; rs4426214; rs2209412; rs6492838; rs9554333; rs7989336; rs11619375; rs765269; rs7981931; rs7317645; rs7982370; rs1164596; rs1927801; rs9584413; rs11069240; rs9513132; rs7330471; rs7995922; rs7331395; rs9554365; rs1328048; rs9516703; rs11617707; rs7330650; rs9513118; rs6491294; rs2038823; rs7999043; rs4131181; rs7993804; rs426351; rs878950; rs4771939; rs7983691; rs11616976; rs9516692; rs10744915; rs7332928; rs11069241; rs1410344; rs1831094; rs6492840; rs11841294; rs1328056; rs625346; rs1888977; rs9562057; rs7985150; rs1336097; rs6491305; rs9302096; rs7320065; rs9554351; rs1924587; rs9284173; rs9525149; rs1927788; rs9516685; rs11618704; rs9584346; rs11617668; rs8002510; rs2149318; rs401152; rs2784790; rs7329719; rs1336085; rs6491291; rs3899870; rs9300366; rs4771926; rs517294; rs672988; rs732103; rs4771942; rs1336096; rs1888976; rs9554341; rs17770292; rs9525135; rs1319307; rs2152480; rs1925127; rs1164588; rs11069237; rs7321538; rs912694; rs2149317; rs9300342; rs1319306; rs7323137; rs4773943; rs1572392; rs9516660; rs915460; rs7332250; rs532837; rs1924591; rs9582047; rs9513139; rs684902; rs732121; rs9554335; rs2209861; rs486968; rs4111145; rs6491308; rs11070159; rs9513119; rs1576157; rs1327631; rs12584926; rs7316935; rs7320184; rs655661; rs10492588; rs4441137; rs2389670; rs7322913; rs1952340; rs675144; rs7328671; rs4773940; rs9513134; rs511283; rs11618119; rs7330499; rs9513140; rs17767526; rs2389631; rs729174; rs11618559; rs3848008; rs6491298; rs1930219; rs9300352; rs527680; rs2784475; rs4456362; rs7335367; rs9634489; rs9556574; rs12854187; rs11618312; rs12019735; rs12431147; rs9516712; rs11618911; rs7991193; rs514895; rs9302091; rs2389672; rs9554349; rs9516768; rs9513152; rs11618434; rs13378217; rs2389658; rs7332438; rs12583988; rs649322; rs7982913; rs524681; rs4773944; rs2389665; rs732123; rs9556541; rs6491292; rs17767562; rs643765; rs11069235; rs7320735; rs9513161; rs9556607; rs11618566; rs7991071; rs1328050; rs1925107; rs490016; rs1164587; rs2149316; rs11617040; rs1414622; rs11841259; rs653469; rs1924589; rs1924574; rs9556617; rs2389715; rs4771927; rs9554345; rs7329150; rs10492589; rs3848009; rs671620; rs1327630; rs1012286; rs1925113; rs7994857; rs9300356; rs535812; rs17675800; rs11618316; rs7320834; rs9302094; rs11618831; rs12585736; rs7322488; rs7987042; rs11619872; rs9513185; rs11842256; rs7320658; rs2389696; rs16953449; rs7331762; rs16953570; rs6491299; rs7330175; rs6492837; rs1924584; rs16953562; rs522005; rs4771943; rs7338183; rs544815; rs752328; rs7323929; rs3900019; rs1952341; rs648241; rs7997409; rs16951661; rs2389629; rs1930223; rs9584386; rs7987437; rs1925131; rs1925130; rs11616787; rs1887602; rs9556551; rs11616237; rs1924597; rs11839867; rs7991843; rs2182065; rs602540; rs6491287; rs9556581; rs472092; rs546399; rs11620340; rs1410338; rs2050537; rs1924573; rs9556576; rs9805568; rs9516766; rs7320054; rs1832176; rs1924576; rs986967; rs7318317; rs1854262; rs645595; rs912693; rs4771250; rs7331591; rs7322056; rs16951714; rs1924582; rs11842574; rs9302092; rs752326; rs12585563; rs7321045; rs7984995; rs9634490; rs13378485; rs510339; rs1328059; rs9513133; rs16951472; rs9562032; rs10161817; rs9590373; rs1925129; rs7328493; rs12583999; rs17769587; rs2389697; rs7358912; rs9516714; rs9513121; rs11841354; rs6492841; rs4771928; rs9513142; rs4771947; rs12864425; rs1927784; rs986968; rs7322060; rs16952910; rs10508028; rs9556567; rs7321124; rs17760491; rs16953554; rs1327632; rs10047765; rs12323049; rs9516762; rs1924586; rs1336100; rs2389716; rs11617369; rs6491296; rs9562025; rs7996549; rs7999519; rs7988667; rs7999958; rs4362239; rs6492843; rs4771953; rs664464; rs7990583; rs2209323; rs1177433; rs966458; rs7139460; rs9584410; rs16953447; rs4771944; rs1328060; rs574959; rs8001127; rs7996639; rs9513150; rs12877270; rs9525142; rs12585655; rs6491288; rs1927785; rs2262077; rs9300358; rs9516673; rs2892823; rs7982697; rs11617543; rs11620111; rs9300351; rs12020934; rs748457; rs534010; rs7998759; rs1854263; rs6492835; rs547571; rs7987457; rs1924583; rs7330979; rs8001566; rs16953068; rs9554340; rs7337506; rs515838; rs1924575; rs9525164; rs628878; rs4771935; rs3893234; rs7318265; rs4771949; rs1927806; rs976322; rs526702; rs7336212; rs530195; rs9513127; rs7323705; rs586555; rs1327640; rs2182067; rs927710; rs11620286; rs1002164; rs7319560; rs11619328; rs1540609; rs7326687; rs4771945; rs7997562; rs5006734; rs12871890; rs1925109; rs9516700; rs4771253; rs729175; rs1414624; rs4771954; rs16951476; rs7319629; rs2010925; rs9556550; rs8002865; rs9513131; rs9516643; rs612671; rs11619806; rs7986153; rs7995242; rs626317; rs12866071; rs7998711; rs9300364; rs9554361; rs732122; rs745003; rs9516761; rs9582062; rs12585417; rs11617420; rs9300345; rs9516760; rs7318798; rs474736; rs1924579; rs9584345; rs16951635; rs16953106; rs7982407; rs4625590; rs3932644; rs9584409; rs11617255; rs2182988; rs539293; rs9584375; rs658705; rs7992063; rs9556529; rs9516649; rs2209411; rs7338504; rs16953568; rs10851065; rs16953069; rs1164594; rs11843551; rs16953365; rs9556540; rs1536577; rs1327627; rs16951729; rs7993716; rs1072563; rs9556621; rs492744; rs11619747; rs16953597; rs7999735; rs9516638; rs6491309; rs12876541; rs1987898; rs12561187; rs3904716; rs9516680; rs522095; rs9525161; rs11616450; rs7318805; rs658122; rs11839482; rs11617368; rs12859541; rs1924581; rs9513128; rs6491289; rs9582065; rs9556565; rs9584355; rs1927786; rs9582046; rs7321355; rs12430998; rs377676; rs7317783; rs2849438; rs912695; rs12560382; rs9516687; rs7326887; rs6492834; rs7335644; rs7320210; rs656180; rs7999955; rs647811; rs16951625; rs9525169; rs606261; rs2018153; rs627074; rs7981815; rs7330875; rs7139716; rs600577; rs9554359; rs2209901; rs487214; rs7989463; rs490753; rs2784474; rs9516706; rs1927797; rs1107220; rs7337860; rs748458; rs2892814; rs17689793; rs9554364; rs1952342; rs12584988; rs543775; rs7990098; rs7328472; rs9516644; rs17235447; rs7328325; rs7335011; rs9584380; rs3858769; rs3886692; rs2224881; rs9590375; rs568170; rs9300355; rs9584376; rs1925114; rs683687; rs1927804; rs12873923; rs7334263; rs9516719; rs640905; rs16951682; rs7334728; rs16953175; rs680576; rs995068; rs502311; rs9590361; rs9516732; rs9513126; rs7325654; rs11617272; rs3932553; rs671597; rs2389695; rs654903; rs12430442; rs16951658; rs553373; rs1536656; rs7334786; rs12873839; rs9556555; rs16953072; rs7998221; rs603250; rs12429344; rs1925123; rs491059; rs1536576; rs1164593; rs1854174; rs9556622; rs7988397; rs11620193; rs2011392; rs9805850; rs9525136; rs9556629; rs17697212; rs16953159; rs9525146; rs9584387; rs9584361; rs9513181; rs9556597; rs7333386; rs9513149; rs12863966; rs11620495; rs644687; rs2389714; rs11842793; rs538416; rs9525150; rs16953103; rs9554338; rs1924585; rs552088; rs1815354; rs16951586; rs732104; rs1327628; rs4415884; rs9562047; rs6492833; rs598806; rs9554353; rs2050538; rs3848014; rs7317478; rs9516665; rs7330076; rs7331682; rs9516767; rs11842501; rs3904717; rs9556532; rs17189979; rs1410265; rs9513130; rs16953393; rs9300353; rs1999026; rs669548; rs9556613; rs1796761; rs4119691; rs2784794; rs659219; rs9584399; rs578818; rs7998169; rs9525172; rs4771962; rs7320403; rs7328915; rs16953592; rs4771964; rs2147689; rs8000808; rs11842188; rs16953390; rs7317859; rs9584411; rs4465470; rs9590362; rs9584367; rs671556; rs9516717; rs9516764; rs9556554; rs2104657; rs541736; rs16952941; rs7334107; rs3843682; rs9634493; rs9516763; rs493423; rs11616566; rs17189986; rs7337417; rs11619600; rs9300347; rs1327633; rs571574; rs11620207; rs12872687; rs7400294; rs553236; rs7323056; rs1927798; rs9584365; rs544019; rs9516651; rs16951691; rs9554363; rs9516683; rs520033; rs1932498; rs9516664; rs11840842; rs2104633; rs2389657; rs16951711; rs6491286; rs9516734; rs575251; rs1925102; rs9556562; rs10467348; rs9516661; rs7324113; rs9513151; rs1328053; rs7327623; rs17268714; rs11617487; rs4460931; rs12583905; rs12427478; rs9516731; rs9582042; rs7139605; rs9554331; rs1327624; rs4119692; rs4771936; rs7982068; rs8001276; rs7321902; rs9556553; rs9554352; rs686672; rs16953595; rs9525171; rs9582060; rs11618287; rs9556533; rs9562042; rs9584391; rs9556538; rs11620555; rs16953121; rs9513166; rs1927800; rs16953424; rs16951630; rs9300339; rs7328359; rs9525173; rs9562044; rs9300340; rs9300354; rs656229; rs4771958; rs7329209; rs2011405; rs16951722; rs7995352; rs2021334; rs980277; rs12875799; rs492639; rs7989026; rs16953101; rs6492831; rs4771965; rs9582049; rs9584348; rs7990281; rs16953158; rs2892824; rs535975; rs12583324; rs2151084; rs16953190; rs7999186; rs4771924; rs6491293; rs1925099; rs7318449; rs9525145; rs7139408; rs12583401; rs7322965; rs11841678; rs17771012; rs11840837; rs17189965; rs9525170; rs9525167; rs3899546; rs9556570; rs2389664; rs17678346; rs2149315; rs9582067; rs662126; rs11617944; rs9556537; rs9513186; rs9525131; rs1327625; rs3848012; rs11616238; rs1107219; rs404177; rs1763703; rs8000148; rs9513146; rs495214; rs16953149; rs625319; rs9562060; rs9516672; rs9556616; rs4341632; rs547858; rs9584390; rs1927795; rs9582041; rs648751; rs9582061; rs4520699; rs1336095; rs9562056; rs988500; rs1927787; rs2389669; rs17769798; rs7987636; rs11838465; rs16951727; rs7323727; rs17677055; rs524257; rs533391; rs11620222; rs9556625; rs1327915; rs9556623; rs476728; rs7983227; rs2183981; rs7989766; rs9516689; rs4773939; rs9562037; rs3899871; rs9582053; rs17687880; rs1925125; rs11620269; rs680676; rs9516736; rs8000589; rs9516646; rs9556543; rs7983697; rs11840847; rs661703; rs7992570; rs11842755; rs1925100; rs9300360; rs3897950; rs598421; rs7318247; rs9513124; rs9582059; rs1164589; rs9582044; rs650488; rs12146909; rs9590371; rs1925105; rs9513129; rs11616401; rs621973; rs9556594; rs9513167; rs7328309; rs9513184; rs12583996; rs16951654; rs11616767; rs16951460; rs537510; rs2389656; rs568945; rs504340; rs7991599; rs9556620; rs9584366; rs9516652; rs7334027; rs7983282; rs7330233; rs816117; rs485648; rs1410264; rs519056; rs11839363; rs9516639; rs9556559; rs9516681; rs11616292; rs3848010; rs9516677; rs9584408; rs9584347; rs1344130; rs9562026; rs4773942; rs11616565; rs6492832; rs694081; rs9525139; rs9516759; rs6492839; rs6491300; rs480651; rs9516733; rs4381453; rs7995680; rs7336275; rs1304278; rs1925111; rs9805649; rs11617726; rs9584342; rs16953560; rs1925124; rs449524; rs7999459; rs7983926; rs9525153; rs9590372; rs9582048; rs9919858; rs9582068; rs11617706; rs9584388; rs16951655; rs9516678; rs493576; rs547575; rs7326735; rs9554358; rs9516721; rs11619967; rs9556582; rs11618298; rs10454558; rs496920; rs16952921; rs16951620; rs11617061; rs9562038; rs9513143; rs9513148; rs7991541; rs9525132; rs579606; rs1610394; rs9556626; rs9300343; rs4771925; rs4771941; rs682645; rs9525165; rs7999291; rs9516688; rs9516647; rs1925122; rs7329846; rs9525168; rs2182987; rs11616773; rs7323496; rs9554343; rs766116; rs11620196; rs9584363; rs16951718; rs9707097; rs16953108; rs4771932; rs9513164; rs7323157; rs7328539; rs1410341; rs16953115; rs9645884; rs4547219; rs11616724; rs11618108; rs41405545; rs35508663; rs34482841; rs34056486; rs1055872; rs35640739; rs35540918; rs28653148; rs3052065; rs34832110; rs3832883; rs3052063; rs7338750; rs34818702; rs35127481; rs656517; rs13378474; rs9556558; rs680079; rs9556602; rs10644683; rs1410345; rs10655542; rs9562058; rs35877373; rs3848011; rs17687228; rs9562027; rs12866328; rs1763704; rs35035018; rs489239; rs34588728; rs35054514; rs35162949; rs598900; rs9516727; rs9582043; rs34235204; rs9554339; rs34830097; rs12560870; rs545309; rs7987331; rs7993683; rs12019477; rs28695529; rs9513179; rs34003928; rs34927088; rs11619574; rs35926456; rs35188467; rs34708616; rs9556575; rs3051282; rs9516743; rs7320712; rs550617; rs9516653; rs9590376; rs35890797; rs952914; rs10671787; rs1925117; rs2389713; rs9584392; rs7984577; rs9634492; rs35916761; rs9556547; rs35072749; rs9554348; rs9634488; rs4551889; rs10678054; rs35417653; rs2389671; rs7334576; rs35326869; rs4627184; rs35508229; rs5805955; rs5805962; rs4516072; rs7342480; rs9584398; rs35428857; rs7318775; rs11317656; rs33978651; rs3051248; rs35616921; rs7333329; rs12583933; rs11395557; rs28502341; rs4569116; rs9584360; rs12870107; rs2784793; rs533660; rs4603419; rs12020269; rs9590367; rs10603092; rs36091104; rs9554332; rs9556588; rs11267263; rs35392626; rs34832894; rs34470820; rs5805990; rs4771963; rs9556615; rs12560508; rs10565996; rs35978505; rs1327917; rs9516711; rs12584145; rs35071073; rs9522624; rs33940721; rs35929255; rs9584383; rs35708780; rs12372827; rs11310861; rs11311782; rs9516756; rs35276180; rs28429945; rs11842406; rs35706258; rs9516708; rs36083339; rs11842401; rs11427641; rs7992840; rs9554354; rs9584357; rs10610677; rs2389699; rs34469717; rs28619408; rs35626911; rs35665546; rs10716120; rs1925101; rs624521; rs568048; rs9513175; rs35869066; rs411581; rs35798570; rs3084992; rs1159854; rs9300348; rs1854260; rs5805974; rs35544754; rs34911359; rs17767940; rs34412759; rs12868267; rs1164590; rs12869010; rs9516650; rs28507869; rs35328815; rs34000071; rs4771931; rs547994; rs9584397; rs34679351; rs28684757; rs7329624; rs4097381; rs34170756; rs35178307; rs34668589; rs35791944; rs34314795; rs12870106; rs9516659; rs648738; rs34517141; rs36026016; rs35193782; rs10591019; rs9556579; rs9516637; rs28415280; rs497407; rs673896; rs12875619; rs34598894; rs9516765; rs1164595; rs7321564; rs9584412; rs9556530; rs11423735; rs35805243; rs12017580; rs12867860; rs34637145; rs35639103; rs35902744; rs34545729; rs11839345; rs35436126; rs34619455; rs35598365; rs9562054; rs9525159; rs499673; rs9513123; rs611830; rs35174180; rs9590366; rs9556569; rs9516679; rs34359547; rs36080119; rs34994956; rs5805983; rs34160113; rs35265699; rs4773937; rs12874246; rs7330731; rs9554350; rs5805966; rs11382293; rs9516751; rs28507439; rs9513180; rs35869095; rs28527414; rs2389627; rs9516724; rs5805952; rs34398037; rs9556590; rs9554344; rs1927802; rs549640; rs34156275; rs9525157; rs3893400; rs5805965; rs568781; rs12875526; rs35913293; rs5805959; rs12871867; rs5805988; rs28379721; rs35438641; rs10559894; rs9525148; rs16953552; rs34286286; rs7993503; rs35618068; rs12431346; rs35588648; rs35220919; rs35876776; rs34292615; rs10670629; rs35335571; rs1887603; rs9516674; rs9562040; rs9556618; rs1932497; rs35044138; rs12864552; rs34101169; rs34452273; rs12868352; rs34577225; rs11842002; rs34560528; rs28521643; rs12861521; rs523742; rs9516735; rs9513141; rs5805971; rs34281865; rs28703729; rs35159739; rs34643797; rs35756416; rs10636972; rs5805954; rs9669853; rs34841773; rs7329830; rs5805984; rs9584393; rs35377735; rs11274254; rs9516654; rs9525130; rs7332318; rs34010759; rs13379014; rs35868978; rs9652108; rs9582063; rs34964862; rs9584368; rs35062794; rs12877113; rs28622381; rs36050314; rs34399950; rs9525155; rs9554342; rs11317588; rs9516675; rs9562024; rs485297; rs11616575; rs11618712; rs4578518; rs659231; rs36035899; rs35120014; rs35913653; rs11372270; rs36089670; rs12872297; rs12100411; rs12100246; rs551524; rs1813862; rs35530266; rs9562059; rs7329530; rs9556560; rs35523192; rs12585140; rs28612535; rs9525126; rs9516757; rs8002711; rs9516705; rs10603063; rs640357; rs34384049; rs548020; rs34093885; rs11300062; rs11344992; rs1887598; rs9584406; rs685253; rs9513144; rs34013320; rs28837460; rs7321303; rs12871644; rs35776798; rs609565; rs5805978; rs34163842; rs3051177; rs34133146; rs656573; rs9584382; rs3051285; rs5805969; rs34746336; rs4576933; rs12869851; rs35063443; rs35764592; rs34692879; rs1319196; rs539070; rs9582045; rs11839592; rs34704635; rs34463956; rs529374; rs12873538; rs9516752; rs34638249; rs35413505; rs3904715; rs34966204; rs12018125; rs35455706; rs34142366; rs9562055; rs9300362; rs11617585; rs9584372; rs1034037; rs35699879; rs28733330; rs34070284; rs9525162; rs34264454; rs1410337; rs33957513; rs34488459; rs34439363; rs12865683; rs9554360; rs12430207; rs34319932; rs7317333; rs9556571; rs9584414; rs9556580; rs11424449; rs35527747; rs7983034; rs35183653; rs1927799; rs12854671; rs9582056; rs12870839; rs35999681; rs17679013; rs36061380; rs34569932; rs28514798; rs34718339; rs34102627; rs12583327; rs34766080; rs9516641; rs12560702; rs2152479; rs9556548; rs35034203; rs35266831; rs579608; rs12867839; rs7335505; rs9516693; rs11318795; rs35693667; rs3052119; rs34890624; rs4628811; rs11327274; rs10550197; rs10558782; rs12854660; rs9556586; rs3084966; rs3052120; rs6491295; rs9562048; rs7984382; rs7993377; rs12184796; rs12560835; rs9562028; rs2209860; rs5805975; rs1336099; rs36055590; rs5805972; rs12561053; rs11414052; rs9554334; rs35933167; rs1854261; rs10580728; rs5805951; rs34324985; rs11442506; rs12560495; rs656121; rs9516728; rs28729495; rs12859141; rs34579416; rs35708749; rs3051040; rs7335838; rs7993417; rs12874126; rs748459; rs35638307; rs9516671; rs28394105; rs11408188; rs7320228; rs34836447; rs9562041; rs35011448; rs9516668; rs9556596; rs4771959; rs8002363; rs10542516; rs9525137; rs35367936; rs35279104; rs34072478; rs35568024; rs34742378; rs13378645; rs11285929; rs34000262; rs9584344; rs10646361; rs9516740; rs34987152; rs34592605; rs33928351; rs35585725; rs36061970; rs5805980; rs7318300; rs34404493; rs12583538; rs11411556; rs34330246; rs5805958; rs34314756; rs7491299; rs3051062; rs1925126; rs34846112; rs1927805; rs537531; rs9556610; rs34198922; rs7317903; rs533781; rs9516749; rs562879; rs36109725; rs9516725; rs11417564; rs35811263; rs5805989; rs11841880; rs2389628; rs35426574; rs11391988; rs1952420; rs35567224; rs9556536; rs13378157; rs7317819; rs35253485; rs36123349; rs35802060; rs5805964; rs10649246; rs12871981; rs34795316; rs34953602; rs1927803; rs4001570; rs12875290; rs12873546; rs9513125; rs9525163; rs865988; rs10616441; rs12430765; rs9513182; rs34918254; rs608322; rs596713; rs12872537; rs9516730; rs9556612; rs34122232; rs28463882; rs35344974; rs34438913; rs9584362; rs35384242; rs11388070; rs5805979; rs35756587; rs9513145; rs611277; rs35360389; rs35688028; rs9516737; rs34163204; rs34554595; rs9516718; rs34007672; rs12560899; rs34195611; rs17686530; rs4001551; rs28460771; rs35732205; rs36036853; rs7338477; rs12584735; rs1962494; rs9584370; rs41442845; rs36110502; rs9584385; rs9525138; rs637654; rs5805976; rs34201099; rs28714973; rs995069; rs1927810; rs12867152; rs7997284; rs34993285; rs4556658; rs35703803; rs36108080; rs12372819; rs28548952; rs9556563; rs10688659; rs35595451; rs35440150; rs486966; rs9584369; rs34504264; rs35702349; rs35714195; rs34935697; rs34997012; rs9584373; rs11377209; rs9525133; rs9516676; rs34578521; rs28542210; rs9556604; rs10632047; rs10590076; rs9516720; rs35773012; rs36207287; rs1763702; rs34855568; rs1328047; rs576133; rs34207658; rs9556556; rs35200165; rs11619142; rs34888653; rs1969958; rs9582051; rs35646010; rs34095776; rs35113984; rs1577607; rs35503651; rs35741442; rs34864787; rs11619114; rs9516669; rs9300349; rs12146891; rs12100208; rs9590374; rs1327629; rs7336870; rs2389660; rs3939487; rs12857315; rs9556573; rs4001473; rs9554346; rs9554357; rs3086049; rs35348223; rs5805985; rs35792588; rs12876834; rs9805419; rs1924592; rs637587; rs34366266; rs5805968; rs5805957; rs35973893; rs4268619; rs7986806; rs9556549; rs8002948; rs10694542; rs9513174; rs34969892; rs9516697; rs12866768; rs34355569; rs625709; rs11617269; rs4262817; rs35660439; rs12853329; rs35185165; rs9584401; rs10692212; rs9516701; rs1887601; rs9513136; rs12560834; rs35994946; rs7997176; rs34652092; rs11304937; rs34985763; rs35048783; rs11841125; rs7998336; rs11407839; rs16953545; rs9300361; rs11334148; rs9590363; rs9562049; rs9556585; rs1002163; rs12868366; rs35358093; rs12866218; rs35782589; rs12857951; rs9516662; rs9516758; rs12870648; rs35214770; rs35616682; rs9516741; rs35695537; rs656520; rs35600636; rs551700; rs1024258; rs1555756; rs574772; rs9556619; rs12020783; rs4771930; rs36006676; rs9556605; rs9556557; rs34934475; rs12867069; rs7323615; rs28604465; rs28791873; rs35447097; rs9516636; rs11391162; rs35773635; rs35473806; rs9556545; rs35269636; rs12020148; rs17686931; rs35468816; rs36099717; rs35465356; rs2182066; rs9584359; rs12583758; rs11359400; rs654343; rs476345; rs597035; rs10658744; rs35846966; rs9590364; rs9554337; rs35897576; rs12873008; rs36077215; rs9556577; rs1813005; rs35530396; rs34573136; rs35988577; rs13378296; rs11620230; rs28660619; rs5805973; rs35779033; rs35318492; rs9584389; rs9513177; rs12861779; rs533369; rs12873238; rs35476258; rs11842823; rs9556599; rs595202; rs28433806; rs9516657; rs10677025; rs35566271; rs11410300; rs11619298; rs12874409; rs3051060; rs7321898; rs28392734; rs11470850; rs28490198; rs35120505; rs1336098; rs12871081; rs1117183; rs9525129; rs7985313; rs10676564; rs34183205; rs5805986; rs35266680; rs11619310; rs2389673; rs16953608; rs9584343; rs5805981; rs4511389; rs28626015; rs35809106; rs9525124; rs590549; rs35786793; rs35472732; rs28464248; rs7326800; rs2389661; rs9516710; rs34368037; rs9556609; rs9562043; rs9516709; rs11297281; rs1024259; rs9556630; rs11412704; rs34649123; rs12874857; rs12874540; rs34000278; rs11444695; rs1327626; rs5805953; rs4548722; rs9516698; rs507330; rs35380296; rs9516738; rs35977628; rs34597584; rs9556564; rs36008077; rs12861115; rs34853293; rs35383010; rs9584384; rs5805963; rs35757517; rs7982375; rs34683325; rs13378647; rs11323357; rs34392235; rs9556552; rs12583812; rs34192912; rs35727910; rs11321729; rs35924360; rs36081796; rs9556601; rs28560368; rs34804090; rs34316382; rs34162397; rs35461089; rs9556611; rs35278207; rs35427563; rs1924594; rs2784792; rs10450823; rs28643448; rs11842894; rs36080709; rs28525135; rs7986622; rs12854680; rs17687026; rs34651683; rs33958530; rs34496907; rs12146890; rs34056662; rs9554347; rs10571311; rs3939486; rs34674037; rs34648550; rs35244002; rs12868790; rs9513168; rs34625432; rs5805977; rs549518; rs9584371; rs1924593; rs11369957; rs12872679; rs9562033; rs10534465; rs752327; rs36024333; rs1924580; rs10532236; rs5805982; rs34555659; rs9516715; rs36068908; rs11440234; rs10707768; rs10576793; rs11350737; rs9562035; rs9513157; rs5805956; rs34972870; rs35358039; rs35225498; rs35399687; rs9525128; rs551522; rs2389529; rs12867783; rs12869655; rs9516726; rs35807461; rs34839900; rs10585813; rs36061164; rs28427032; rs12869251; rs35073002; rs35882347; rs16953538; rs639039; rs35988688; rs4111146; rs12877326; rs28415839; rs9513183; rs34175804; rs519826; rs581647; rs34202709; rs35531030; rs34370212; rs7334220; rs35011180; rs35737915; rs543342; rs9556572; rs2225200; rs34645447; rs564075; rs7319851; rs9562029; rs9556546; rs9590369; rs9584374; rs35481292; rs35754324; rs9556606; rs34464839; rs35044738; rs34177264; rs4773936; rs35285442; rs9645885; rs35525760; rs35710213; rs9590365; rs34899315; rs34214323; rs36089682; rs2389659; rs34006269; rs34638168; rs34560704; rs4771256; rs33987072; rs34112219; rs34175542; rs28373420; rs1555757; rs10712847; rs9513147; rs35092596; rs9516750; rs12870110; rs35571092; rs1540608; rs7325316; rs35346698; rs9556568; rs35171535; rs11841191; rs35712099; rs3931489; rs28447379; rs5805967; rs36210517; rs36055654; rs2389666; rs35697344; rs17756665; rs763978; rs745176; rs11843407; rs9516699; rs7988861; rs34659421; rs34595778; rs10694617; rs34845658; rs36033457; rs2389698; rs34959900; rs34707078; rs11278040; rs35020295; rs28446258; rs536268; rs34784232; rs34116879; rs5805960; rs12871045; rs9513120; rs35658808; rs35420472; rs35692915; rs614862; rs34130950; rs34973249; rs9584395; rs9556598; rs9556526; rs695105; rs35877616; rs3848013; rs7330415; rs11842417; rs35040342; rs35515165; rs9582054; rs34520122; rs9516695; rs34650114; rs9562051; rs12050036; rs605396; rs9516707; rs34812238; rs9516656; rs34107441; rs12020279; rs10632510; rs9634491; rs35934125; rs12869416; rs36023430; rs35582866; rs35540374; rs11432080; rs9556600; rs12870147; rs36063950; rs3084964; rs9740766; rs34703676; rs7339010; rs539261; rs557126; rs16953600; rs816107; rs3886291; rs7981687; rs34317882; rs9584381; rs34598011; rs11348541; rs12560575; rs11451045; rs34381263; rs35631408; rs9556561; rs3051066; rs35708188; rs12017097; rs34819860; rs12050064; rs12866108; rs34328324; rs9584379; rs36032594; rs12100266; rs11402806; rs7338695; rs7327127; rs9513178; rs9516770; rs11839766; rs11455526; rs35860414; rs9516658; rs35227555; rs5805970; rs4771955; rs656201; rs35215447; rs35354163; rs11842403; rs35968473; rs11841072; rs34431914; rs481049; rs34763066; rs34481001; rs11069246; rs12020987; rs12561039; rs1327637; rs16953617; rs1924577; rs2129006; rs2170813; rs2389667; rs4098230; rs527096; rs534429; rs540213; rs5805961; rs581462; rs593806; rs643302; rs7316999; rs7321935; rs7335541; rs7336194; rs9300367; rs9582070; rs9582072

# Macromolecular_Interacting_Partner_6_General_References:
Not Available

# Macromolecular_Interacting_Partner_6_References:
Not Available

End of HMDB00061

Beginning of HMDB00062
# Accession_No:
HMDB00062

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-22 10:45:15

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
L-Carnitine

# Description:
Carnitine is not an essential amino acid; it can be synthesized in the body. However, it is so important in providing energy to muscles including the heart-that some researchers are now recommending carnitine supplements in the diet, particularly for people who do not consume much red meat, the main food source for carnitine. Carnitine has been described as a vitamin, an amino acid, or a metabimin, i.e., an essential metabolite. Like the B vitamins, carnitine contains nitrogen and is very soluble in water, and to some researchers carnitine is a vitamin (Liebovitz 1984). It was found that an animal (yellow mealworm) could not grow without carnitine in its diet. However, as it turned out, almost all other animals, including humans, do make their own carnitine; thus, it is no longer considered a vitamin. Nevertheless, in certain circumstances-such as deficiencies of methionine, lysine or vitamin C or kidney dialysis--carnitine shortages develop. Under these conditions, carnitine must be absorbed from food, and for this reason it is sometimes referred to as a "metabimin" or a conditionally essential metabolite. Like the other amino acids used or manufactured by the body, carnitine is an amine. But like choline, which is sometimes considered to be a B vitamin, carnitine is also an alcohol (specifically, a trimethylated carboxy-alcohol). Thus, carnitine is an unusual amino acid and has different functions than most other amino acids, which are most usually employed by the body in the construction of protein. Carnitine is an important amino acid made by the body from lysine. It's most important known metabolic function is to transport fat into the mitochondria of muscle cells, including those in the heart, for oxidation. This is how the heart gets most of its energy. Inborn errors of carnitine metabolism can lead to brain deterioration like that of Reye's syndrome, gradually worsening muscle weakness, Duchenne-like muscular dystrophy and extreme muscle weakness with fat accumulation in muscles. Borurn et al. (1979) have summed up the research by describing carnitine as an essential nutrient for pre-term babies, certain types (non-ketotic) of hypoglycemics, kidney dialysis patients, cirrhosis, and in kwashiorkor, type IV hyperlipidemia, heart muscle disease (cardiomyopathy), and propionic or organic aciduria (acid urine resulting from genetic or other anomalies). In all these conditions and the inborn errors of carnitine metabolism, carnitine is essential to life and carnitine supplements are valuable. Carnitine therapy may also be useful in a wide variety of clinical conditions. Carnitine supplementation has improved some patients who have angina secondary to coronary artery disease. It may be worth a trial in any form of hyperlipidemia or muscle weakness. Carnitine supplements may be useful in many forms of toxic or metabolic liver disease and in cases of heart muscle disease. Hearts undergoing severe arrhythmia quickly deplete their stores of carnitine. Athletes, particularly in Europe, have used carnitine supplements for improved endurance. Carnitine may improve muscle building by improving fat utilization and may even be useful in treating obesity. Carnitine joins a long list of nutrients which may be of value in treating pregnant women, hypothyroid individuals, and male infertility due to low motility of sperm. Even the Physician's Desk Reference gives indication for carnitine supplements as "improving the tolerance of ischemic heart disease, myocardial insufficiencies, and type IV hyperlipoproteinemia. Carnitine deficiency is noted in abnormal liver function, renal dialysis patients, and severe to moderate muscular weakness with associated anorexia." (http://www.dcnutrition.com)

# Synonyms:
(-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate; (-)-carnitine; 1-carnitine; (R)-(3-Carboxy-2-hydroxypropyl)trimethylammonium hydroxide; (r)-carnitine; (s)-carnitine; 3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium; Bicarnesine; Carnilean; Carnitene; Carnitine; Carnitor; D-carnitine; DL-carnitine; Gamma-trimethyl-ammonium-beta-hydroxybutirate; Gamma-trimethyl-beta-hydroxybutyrobetaine; Gamma-trimethyl-hydroxybutyrobetaine; Karnitin; L-(-)-carnitine; L-carnitine; L-gamma-trimethyl-beta-hydroxybutyrobetaine; Levocarnitina; Levocarnitine; Levocarnitine chloride; Levocarnitinum; R-(-)-3-hydroxy-4-trimethylaminobutyrate; Vitamin BT; delta-carnitine

# Chemical_IUPAC_Name:
(3R)-3-hydroxy-4-trimethylammonio-butanoate

# Chemical_Formula:
C7H15NO3

# Chemical_Structure:
tbl_chemical:::HMDB00062_ZOOM.png:::119283166230260140

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00062_THUMB.png:::11928316603657465

# Taxonomy_Kingdom:
Organic Salt

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
anion; carboxylic acid salt; cation; quaternary ammonium salt; secondary alcohol

# Taxonomy_Biofunction:
Essential amino acid; Component of Alanine and aspartate metabolism; Component of Fatty acid metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
161.10519

# Molecular_Weight_Avg:
161.19891

# Smiles_String_isomeric:
C[N+](C)(C)C[C@@H](O)CC([O-])=O

# Smiles_String_canonical:
C[N+](C)(C)CC(O)CC([O-])=O

# KEGG_Compound_ID:
C00318

# BioCyc_ID:
CARNITINE

# PubChem_CID:
2724480

# PubChem_SID:
8787949; 12033862; 3612; 3140006; 8145671; 16190661; 17396022

# OMIM_ID:
201450; 212138; 212140; 212160; 236795; 255120

# Metagene_ID:
EPEMA SYNDROME (ENCEPHALOPATHY, PETECHIAE, ETHYLMALONIC ACIDURIA): 274; CARNITINE TRANSPORTER DEFECT. PRIMARY SYSTEMIC CARNITINE DEFICIENCY: 90; LETHAL INFANTILE CARDIOMYOPATHY: X-LINKED CARDIOSKELETAL MYOPATHY (BARTH SYNDROME): 288; FEEDING: VEGANIAN [DD]: 336; VALPROATE THERAPY: ANTICONVULASANT HYPERSENSITIVITY SYNDROME VALPROATE ASSOCIATED HEPATOTOXICITY: 324; PROPIONIC ACIDEMIA. KETOTIC HYPERGLYCINEMIA (PA): 18; 3-METHYL-CROTONYL-GLYCINURIA: 27; 2,4-DIENOYL-CoA REDUCTASE DEFICIENCY: 437; MALONYL-COA DECARBOXYLASE DEFICIENCY: 28; SHORT CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD): 40; HYPERDIBASIC AMINOACIDURIA II. LYSINURIC PROTEIN INTOLERANCE: 61; LONG-CHAIN-3-HYDROXYACYL-CoA DEHYDROGENASE DEFICIENCY (LCHAD): 308; VERY-LONG-CHAIN ACYL CoA DEHYDROGENASE DEFICIENCY (VLCAD): 392; 3-METHYLGLUTACONIC ACIDURIA, X-LINKED (TYPE II): 24; ISOVALERIC ACIDEMIA: 10; CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY: 342; CARNITINE DEFICIENCY, MYOPATHIC: 282; CARNITINE PALMITOYL TRANSFERASE DEFICIENCY (I): 263; 3-HYDROXYISOBUTYRIC ACIDURIA: 307; MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM: 79; SHORT/BRANCHED-CHAIN ACYL-CoA DEHYDROGENASE DEFICIENCY: 479; MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD): 39; MAMEL (METHYLMALONIC ACIDURIA MITOCHONDRIAL ENCEPHELOPATHY LEIGH-LIKE) A NEW MITOCHONDRIAL ENCEPHALOPATHY: 518; CARNITINE PALMITOYL TRANSFERASE DEFICIENCY (II): 94; ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY: 509; GLUTARIC ACIDURIA II: 9; METHYLMALONIC ACIDURIA (MMA): 15; LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD): 38; ASPHYXIA [DD]: 408; GLUTARIC ACIDURIA I: 8; 3-HYDROXY-3-METHYLGLUTARYL-CoA LYASE DEFICIENCY: 4; BIOTINIDASE DEFICIENCY: 73; BETA-KETOTHIOLASE DEFICIENCY: 5

# BiGG_ID:
34600

# Wikipedia_ID:
L-Carnitine

# METLIN_ID:
52

# Ref_ID:
11880112; 12908852; 9572066; 16368715; 11406104; 14571103; 16300828; 8820505; 10929687; 16227137; 9522638; 16331536; 10094444; 6810706; 16283381; 15193480; 15803480; 11422928; 1643708

# ChEBI_ID:
16347

# CAS_Registry_Number:
541-15-1

# InChI:
InChI=1/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m0/s1

# Synthesis_Reference:
Simple synthesis of (R)-carnitine from D-galactono-1,4-lactone.     Bols, Mikael; Lundt, Inge; Pedersen, Christian.    Dep. Org. Chem.,  Tech. Univ. Denmark,  Lyngby,  Den.    Tetrahedron  (1992),  48(2),  319-24.

# Melting_Point:
197 oC

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
1000 mg/mL at 25 oC [MEYLAN,WM et al. (1996)]; 5.33 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.90 [Predicted by ALOGPS]; -5.48 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::1166052756.html:::235995192898023>>>tbl_chemical:::1166052758.pdf:::113518683480849

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::1166052811.mol:::173888628569102

# SDF_File_[Text]:
tbl_chemical:::HMDB00062.sdf:::119283165640030581

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00062.pdb:::119283165887199775

# PDB_ID:
1NDF

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041003_P00_05_HW_1DP_Presat.png:::115878020738177382

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041003_P00_05_HW_1DP_Presat.zip:::115878020740999991

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041003_P00_05_HW_1DP_Assigned.png:::116423054121181991

# C_NMR_Spectra:
tbl_cnmr:::041003_P00_05_HW_1DC_65.jpg:::114168476725376431

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041003_P00_05_HW_1DC_65.zip:::114168476722345264

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041003_P00_05_HW_1DC_65_Assigned.jpg:::114322794695763375

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041003_P00_05_HW_2DHSQC_209.jpg:::114495585009859643

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041003_P00_05_HW_2DHSQC_209.zip:::114495585012262655

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041003_P00_05_HW_2DHSQC_209_Assigned.jpg:::114495585028540900

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Carnitine.gif:::1132732104234437825

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00062_peaks.txt:::1156309520408249742

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Carnitine_C.gif:::1132737671507945769

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00062_peaks.txt:::11563107108538458

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00062L.png:::117555262180566540; Medium Energy:tbl_ms:::HMDB00062M.png:::117555267278537888; High Energy:tbl_ms:::HMDB00062H.png:::117555271154175603

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000074.png:::116899931032842100

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000074.txt:::116899931032890204

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000074.png:::116890825839094956

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000074.txt:::116890825865649353

# Cellular_Location:
Cytoplasm; Mitochondria; endoplasmic reticulum; Extracellular; peroxisome

# Tissue_Location:
Adipose Tissue; Bladder; Brain; Erythrocyte; Fibroblasts; Intestine; Kidney; Liver; Lung; Muscle; Myocardium; Nerves; Neurons; Platelet; Skeletal Muscle; Sperm; Testes; Testis

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Blood	33.6 +/- 6.2	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	38.2 +/- 5.4	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	43.0 (26.0-79.0)	umol/L	Adult:>18_yrs_old	Both	Normal	1643708
Cerebrospinal_Fluid(CSF)	4.0 (2.0 - 9.0)	umol/L	Adult:>18_yrs_old	Both	Normal	1643708


# Concentration_[Abnormal]:
Urine	13.3 (11.6-15.1)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Diabetic Ketosis	6810706
Urine	41.3 (38.3-44.2)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Diabetic Ketosis	6810706
Urine	7 (0-30)	umol/mmol_creatinine	N/A	Both	Lung Cancer	


# Associated_Disorders:
2,4-Dienoyl-Coa Reductase Deficiency; 3-Hydroxy-3-Methylglutaric Acidemia; 3-Hydroxyisobutyric Aciduria; 3-Methyl-Crotonyl-Glycinuria; 3-Methylglutaconic Aciduria, X-Linked (Type II); Carnitine Deficiency, Myopathic; Carnitine Palmitoyl Transferase Deficiency (I); Carnitine Palmitoyl Transferase Deficiency (II); Carnitine Transporter Defect: Primary Systemic Carnitine Deficiency; Carnitine-Acylcarnitine Translocase Deficiency; Cirrhosis; Diabetic Ketosis; Epema Syndrome (Encephalopathy, Petechiae, Ethylmalonic Aciduria); Feeding: Veganian [DD]; Glutaric Aciduria I; Hyperdibasic Aminoaciduria II; Isovaleric Acidemia; Lethal Infantile Cardiomyopathy: X-Linked Cardioskeletal Myopathy (Barth Syndrome); Liver Disease; Long Chain Acyl-Coa Dehydrogenase Deficiency (LCAD); Long-Chain-3-Hydroxyacyl-Coa Dehydrogenase Deficiency (LCHAD); Lung Cancer; Lysinuric Protein Intolerance; Malonyl-Coa Decarboxylase Deficiency; Medium Chain Acyl-Coa Dehydrogenase Deficiency (MCAD); Methylmalonic Aciduria (MMA); Preeclampsia; Propionic Acidemia, Ketotic Hyperglycinemia (PA); Short Chain Acyl-Coa Dehydrogenase Deficiency (SCAD); Valproate Therapy: Anticonvulasant Hypersensitivity Syndrome Valproate Associated Hepatotoxicity; Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCADD)

# Pathway_Names:
Lysine degradation;Alanine and aspartate metabolism

# Pathway_Images:
Lysine_degradation.jpg;Aspartate_and_Alanine_metabolism.jpg

# KEGG_Images:
map00310;map00252

# Pathway_Graphs:
Lysine_degradation_Graph.jpg;Aspartate_and_Alanine_metabolism_Graph.jpg

# Pathway_SBMLs:
Lysine_degradation.xml;Aspartate_and_Alanine_metabolism.xml

# Metabolic_Enzyme_1_ID:
5619

# Metabolic_Enzyme_1_Name:
Gamma-butyrobetaine dioxygenase

# Metabolic_Enzyme_1_Synonyms:
Gamma-butyrobetaine,2- oxoglutarate dioxygenase; Gamma-butyrobetaine hydroxylase; Gamma- BBH

# Metabolic_Enzyme_1_Gene_Name:
BBOX1

# Metabolic_Enzyme_1_Protein_Sequence:
>Gammabutyrobetaine dioxygenase
MACTIQKAEALDGAHLMQILWYDEEESLYPAVWLRDNCPCSDCYLDSAKARKLLVEALDV
NIGIKGLIFDRKKVYITWPDEHYSEFQADWLKKRCFSKQARAKLQRELFFPECQYWGSEL
QLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHT
WQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQK
LKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSKHKIIELDDKGQVVRINFNNATRDTIF
DVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISR
HLEGAYADWDVVMSRLRILRQRVENGN

# Metabolic_Enzyme_1_Number_of_Residues:
387

# Metabolic_Enzyme_1_Molecular_Weight:
44715

# Metabolic_Enzyme_1_Theoretical_pI:
6.73

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the formation of L-carnitine from gamma- butyrobetaine

# Metabolic_Enzyme_1_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_1_Reaction:
4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF02668:TauD

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.14.11.1

# Metabolic_Enzyme_1_GenBank_ID_Protein:
3746805

# Metabolic_Enzyme_1_SwissProt_ID:
BODG_HUMAN (O75936)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
BBOX1

# Metabolic_Enzyme_1_Geneatlas_id:
BBOX1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:964

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1164 bp
ATGGCTTGTACCATCCAAAAGGCAGAAGCACTTGACGGGGCTCATTTGATGCAGATCCTC
TGGTATGATGAGGAAGAGTCTCTCTACCCAGCTGTATGGTTGAGAGACAACTGTCCGTGC
TCTGATTGCTACCTGGATTCTGCAAAAGCACGGAAACTTCTAGTGGAAGCTCTTGATGTG
AACATTGGAATTAAAGGCTTGATATTTGACAGAAAAAAGGTGTACATCACATGGCCCGAT
GAGCATTACAGTGAATTCCAGGCTGATTGGCTGAAGAAAAGATGCTTTTCCAAGCAGGCC
AGAGCAAAGCTCCAAAGAGAATTGTTTTTTCCAGAATGCCAATACTGGGGCTCAGAGCTC
CAGCTACCCACTTTGGATTTTGAAGATGTTTTAAGATATGATGAACATGCATACAAGTGG
CTCTCCACCCTCAAGAAAGTAGGCATAGTAAGACTCACCGGAGCATCTGACAAACCAGGA
GAAGTTTCAAAACTTGGGAAAAGGATGGGTTTCCTCTATCTCACATTTTATGGACATACT
TGGCAAGTGCAAGACAAAATCGATGCAAACAATGTGGCTTACACAACTGGGAAGCTAAGC
TTTCACACTGATTATCCAGCCCTCCATCATCCACCTGGGGTTCAGCTTCTTCACTGCATA
AAGCAAACAGTCACAGGGGGTGATTCAGAAATTGTAGATGGGTTTAATGTGTGCCAAAAA
CTAAAGAAAAATAATCCTCAGGCATTCCAGATTTTGTCCTCTACCTTTGTGGACTTTACA
GACATTGGAGTGGATTACTGTGATTTTTCTGTACAATCAAAACATAAAATTATAGAGTTA
GATGATAAAGGCCAAGTGGTTCGCATCAACTTCAATAACGCAACTAGGGACACAATATTT
GATGTACCTGTTGAAAGAGTTCAGCCTTTTTATGCTGCTCTGAAGGAGTTTGTTGACCTC
ATGAACAGCAAAGAATCCAAGTTTACCTTCAAGATGAATCCAGGTGATGTGATTACTTTT
GATAACTGGCGCTTACTTCATGGCCGACGTAGCTATGAAGCAGGAACTGAGATATCCCGC
CATCTAGAAGGAGCTTATGCTGACTGGGATGTGGTCATGTCAAGGCTTCGTATCTTAAGG
CAGAGGGTGGAGAATGGAAACTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF082868

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_1_Locus:
11p14.2

# Metabolic_Enzyme_1_SNPs:
rs3183973; rs1044273; rs12385796; rs11029801; rs10835105; rs10767595; rs10835108; rs4923415; rs7107938; rs1031176; rs1445329; rs7108209; rs1348655; rs9667425; rs10767594; rs1596713; rs11029799; rs1445317; rs2305095; rs7113488; rs7124309; rs11029803; rs7479320; rs11029798; rs1445316; rs11029797; rs11029802; rs4922782; rs10767596; rs1596711; rs4923413; rs1044281; rs11029810; rs1445318; rs1445328; rs7124431; rs10835106; rs10767593; rs11029805; rs987687; rs1317726; rs1442936; rs1550617; rs2015372; rs1470272; rs972904; rs12275053; rs7119888; rs7926773; rs4532991; rs4923423; rs1372902; rs7937175; rs10835118; rs7124821; rs7945305; rs1596252; rs7949619; rs7926376; rs4923424; rs11029818; rs1470270; rs1470271; rs1442924; rs7931643; rs11821389; rs1899506; rs7926257; rs1442934; rs16916562; rs2304912; rs7932626; rs11819947; rs7925797; rs1372903; rs2218317; rs1020269; rs7121579; rs4328173; rs3781677; rs11605939; rs10835109; rs10767609; rs11029819; rs996081; rs7930844; rs4923419; rs7926675; rs11029812; rs10835114; rs1442939; rs1445315; rs1126029; rs11029816; rs11824620; rs17309677; rs4278476; rs17243943; rs1584011; rs1372910; rs2099887; rs1442940; rs6484265; rs10767604; rs1442935; rs10501075; rs1900062; rs2165771; rs2165772; rs1899505; rs7942200; rs7129825; rs7124528; rs2165769; rs16916527; rs17309656; rs16925449; rs7111206; rs1117933; rs12292769; rs10835111; rs2016186; rs1442918; rs10767611; rs12294451; rs7934926; rs12271270; rs7925996; rs10835115; rs12270852; rs7105366; rs1596253; rs11029835; rs11029822; rs1442942; rs7949163; rs7124982; rs2083746; rs2351072; rs1596256; rs10835110; rs10767601; rs12269821; rs11029817; rs17309642; rs11029840; rs7927654; rs16916550; rs10501076; rs11511900; rs12282206; rs2083745; rs9666732; rs11828630; rs7951152; rs1838016; rs10767608; rs2351071; rs7103662; rs11029821; rs17243908; rs10767599; rs16916541; rs11029811; rs11029827; rs7936060; rs7101475; rs12786889; rs7113071; rs10835116; rs12288789; rs7926243; rs1550618; rs12277039; rs11029837; rs11602261; rs16916491; rs10767607; rs10742167; rs1348333; rs2351069; rs12285287; rs4539271; rs17243895; rs16916545; rs1442938; rs10767603; rs1813232; rs7939588; rs985597; rs11029833; rs1372904; rs11029795; rs11029796; rs10767592; rs979894; rs16916476; rs10767598; rs11029804; rs11029809; rs10719276; rs7117298; rs35636374; rs4923417; rs7105192; rs11029806; rs7128441; rs12576172; rs34097371; rs34660864; rs11029808; rs34766807; rs35376713; rs11029800; rs35917669; rs12283507; rs34065143; rs7126240; rs35189764; rs11029807; rs4345921; rs12276511; rs5790623; rs34538592; rs4923416; rs12223912; rs28541300; rs10835107; rs4145909; rs34110652; rs1596712; rs2351065; rs34027150; rs12806691; rs5790624; rs5790626; rs7948922; rs12270866; rs35004823; rs12795106; rs34667672; rs11029814; rs1155086; rs7939156; rs33920700; rs11029823; rs12281762; rs1900061; rs969853; rs7118962; rs2165770; rs1596257; rs1442941; rs34033631; rs7121302; rs2099886; rs4456220; rs34651018; rs34566186; rs35133358; rs7106871; rs12796032; rs1900064; rs12283762; rs10767602; rs996080; rs35379904; rs11029829; rs2351068; rs3858352; rs12798621; rs12285873; rs1442937; rs35762464; rs7124832; rs12290117; rs35689575; rs12280183; rs12795275; rs34531204; rs35556063; rs11029813; rs34883956; rs12417452; rs12797016; rs34406124; rs5790625; rs2218316; rs34886674; rs7933763; rs1899507; rs1596255; rs35869743; rs34503251; rs35209473; rs34621792; rs11336654; rs6484262; rs34420345; rs11354714; rs35233420; rs2351073; rs2120970; rs11396790; rs36115556; rs34989862; rs34990215; rs34914489; rs7930368; rs7128424; rs34552334; rs2351067; rs12281711; rs3077755; rs2197193; rs4923422; rs1900063; rs34309577; rs7126076; rs33933274; rs34717773; rs35737389; rs35645117; rs12291195; rs34595485; rs10597096; rs6484263; rs12419903; rs11029825; rs35248831; rs1822333; rs35620055; rs1156471; rs1126030; rs11820992; rs35105576; rs2351066; rs3077754; rs2304913; rs34317776; rs12795462; rs35203991; rs12803967; rs2351070; rs11373738; rs28635996; rs11029820; rs10589070; rs2197189; rs1126028; rs34754536; rs11371497; rs2197192; rs11029815; rs1596254; rs34399289; rs35655267; rs35671221; rs12282200; rs12049843; rs7478929; rs35821992; rs1900065; rs34920955; rs35825160; rs11029826; rs35329237; rs6484266; rs3214719; rs6484264; rs11442866; rs34255947; rs12796839; rs13377286; rs12796835; rs12277417; rs12291206; rs34851998; rs7358459; rs963185; rs34250561; rs12289983; rs5790630; rs7358458; rs35814179; rs2012032; rs5790629; rs4279971; rs12417081; rs5790628; rs5790627; rs11300902; rs35939379; rs1025879; rs10501077; rs10501078; rs10501079; rs10742166; rs11029792; rs11825838; rs11828263; rs12577769; rs1348331; rs1584010; rs16916608; rs1838009; rs2083743; rs3802783; rs4923411; rs4923412; rs4923425; rs7131593; rs7933314; rs7933773; rs7939644

# Metabolic_Enzyme_1_General_References:
9753662

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5257

# Metabolic_Enzyme_2_Name:
Carnitine O-acetyltransferase

# Metabolic_Enzyme_2_Synonyms:
Carnitine acetylase; CAT; Carnitine acetyltransferase; CrAT

# Metabolic_Enzyme_2_Gene_Name:
CRAT

# Metabolic_Enzyme_2_Protein_Sequence:
>Carnitine Oacetyltransferase
MLAFAARTVVKPLGFLKPFSLMKASSRFKAHQDALPRLPVPPLQQSLDHYLKALQPIVSE
EEWAHTKQLVDEFQASGGVGERLQKGLERRARKTENWLSEWWLKTAYLQYRQPVVIYSSP
GVMLPKQDFVDLQGQLRFAAKLIEGVLDFKVMIDNETLPVEYLGGKPLCMNQYYQILSSC
RVPGPKQDTVSNFSKTKKPPTHITVVHNYQFFELDVYHSDGTPLTADQIFVQLEKIWNSS
LQTNKEPVGILTSNHRNSWAKAYNTLIKDKVNRDSVRSIQKSIFTVCLDATMPRVSEDVY
RSHVAGQMLHGGGSRLNSGNRWFDKTLQFIVAEDGSCGLVYEHAAAEGFPIVTLLDYVIE
YTKKPELVRSPMVPLPMPKKLRFNITPEIKSDIEKAKQNLSIMIQDLDITVMVFHHFGKD
FPKSEKLSPDAFIQMALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSASMDSLTFVK
AMDDSSVTEHQKVELLRKAVQAHRGYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMD
TSYAIAMHFHLSTSQVPAKTDCVMFFGPVVPDGYGVCYNPMEAHINFSLSAYNSCAETNA
ARLAHYLEKALLDMRALLQSHPRAKL

# Metabolic_Enzyme_2_Number_of_Residues:
626

# Metabolic_Enzyme_2_Molecular_Weight:
70927

# Metabolic_Enzyme_2_Theoretical_pI:
8.63

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria

# Metabolic_Enzyme_2_Pathway:
map00252  Alanine and aspartate metabolism

# Metabolic_Enzyme_2_Reaction:
acetyl-CoA + carnitine = CoA + O-acetylcarnitine

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00755:Carn_acyltransf

# Metabolic_Enzyme_2_Signals:
1-16

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.3.1.7

# Metabolic_Enzyme_2_GenBank_ID_Protein:
927415

# Metabolic_Enzyme_2_SwissProt_ID:
CACP_HUMAN (P43155)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
CRAT

# Metabolic_Enzyme_2_Geneatlas_id:
CRAT

# Metabolic_Enzyme_2_hgnc_id:
HGNC:2342

# Metabolic_Enzyme_2_PDB_ID:
1S5O

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Endoplasmic reticulum (Potential). Peroxisome (Potential). Mitochondrion; mitochondrial inner membrane; matrix side (Potential)

# Metabolic_Enzyme_2_Gene_Sequence:
>1876 bp
AGCCTTCGCTGCCAGGACCGTGGTGAAGCCTCTGGGCTTCCTGAAGCCCTTCTCCTTGAT
GAAGGCTTCCAGCCGCTTCAAGGCACACCAGGATGCCCTGCCACGGCTGCCCGTGCCCCC
TCTCCAGCAGTCCCTGGACCACTACCTGAAGGCGCTGCAGCCCATCGTGAGTGAGGAGGA
GTGGGCCCACACCAAGCAGCTGGTGGATGAGTTTCAGGCCTCAGGAGGTGTAGGGGAGCG
CCTGCAGAAGGGGCTGGGGCGTCGGGCCAGGAAGACGGAGAACTGGCTGTCTGAGTGGTG
GCTCAAGACCGCCTACCTCCAGTACCGCCAGCCTGTGGTCATCTACTCGAGCCCAGGCGT
GATGCTACCCAAGCAGGACTTCGTGGACCTGCAGGGTCAGCTCCGATTTGCTGCCAAACT
CATTGAGGGTGTGTTGGATTTCAAGGTCATGATTGACAACGAGACCCTGCCCGTGGAGTA
CCTGGNGGGGAAGCCACTGTGCATGAACCAGTACTATCAGATCTTGTCCTCCTGCCGAGT
GCCGGGCCCCAAGCAGGACACAGTCAGCAACTTCAGCAAGACCAAGAAGCCTCCCACGCA
CATCACCGTGGTACACAACTACCAGTTTTTTGAGCTGGATGTGTACCACAGTGACGGGAC
ACCCCTCACTGCGGATCAGATCTTTGTGCAGCTGGAGAAGATCTGGAACTCATCCCTACA
GACCAACAAGGAGCCTGTGGGCATCCTCACCTCCAACCACCGCAACTCCTGGGCCAAGGC
ATACAACACCCTCATCAAAGACAAGGTGAACCGGGATTCCGTGCGCTCCATCCAGAAGAG
CATCTTCACCGTGTGCCTAGATGCAACCATGCCCAGGGTCTCAGAAGACGTGTACCGCAG
CCACGTGGCAGGCCAGATGCTGCATGGGGGCGGCAGCAGGCTCAACAGCGGCAACCGCTG
GTTTGACAAGACGCTGCAGTTCATCGTGGCAGAAGATGGCTCCTGTGGGCTTGTGTACGA
GCATGCTGCAGCNGAGGGTTTCCCTATTGTCACCCTTCTGGACTATGTCATCGAGTACAC
GAAGAAACCCGAGCTTGTGCNGTCTCCCATGGTGCCCCTGCCCATGCCCAAGAAGCTGCG
GTTCAACATCACCCCCGAGATCAAGAGCGACATCGAGAAGGCCAAGCAGAACCTCAGCAT
CATGATCCANNACCTGGATATCACCGTGATGGTGTTCCACCATTTTGGAAAAGACTTCCC
CAAGTCGGAGAAGCTAAGCCCAGATGCCTTCATCCAGATGGCTTTGCAGCTGGCCTACTA
CAGGATCTACGGACAGGCATGTGCCACCTATGAAAGTNCNTCCCTGCGCATGTTTCACCT
GGGCCGCACCGACACCATCCGCTCGGCTTCCATGGACTCACTCACCTTTGTCAAGGCCAT
GGATGACTCCAGCGTCACGGAGCACCAGAAGGTGGAGCTGCTGCGGAAGGCCGTGCAGGC
CCACCGGGGCTACACCGACCGGGCCATCCGCGGGGAGGCCTTTGGTCGACACCTGCTGGG
CCTGAAGCTGCAGGCCATCGAGGACCTGGTGAGCACGCCCGACATCTTCATGGACACCTC
CTACGCCATCGCCATGCACTTCCACCTCTCCACCAGCCAGGTCCCTGCCAAGACAGACTG
TGTCATGTTCTTCGGGCCCGTGGTCCCCGACGGCTACGGTGTCTGCTATAACCCCATGGA
GGCCCACATCAACTTCTCCCTGTCGGCCTACAACAGCTGCGCGGAGACCAACGCCGCCCG
CCTGGCGCATTACCTGGAGAAGGCGCTCCTGGACATGCGTGCCCTGCTGCAGAGCCACCC
CCGGGCCAAGCTCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X78706

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_2_Locus:
9q34.1

# Metabolic_Enzyme_2_SNPs:
rs17459086; rs16930895; rs2296770; rs1127926; rs4836635; rs2229419; rs2296771; rs3780691; rs17481672; rs17486052; rs17486213; rs1044555; rs3118638; rs3124498; rs4837340; rs10819462; rs7866897; rs746872; rs2148852; rs746873; rs3780690; rs746874; rs3124499; rs10988204; rs1359845; rs2768630; rs12005112; rs1977447; rs2274476; rs2274477; rs10819463; rs3739842; rs12553915; rs4836636; rs17508619; rs2274478; rs4837337; rs17508557; rs17486066; rs10988202; rs17486199; rs10988203; rs6478862; rs746871; rs17508564; rs17486122; rs17481651; rs7042928; rs10739741; rs3124495; rs3124496; rs7046990; rs3118639; rs11564078; rs12342825; rs10988200; rs13289043; rs17481561; rs17508516; rs7032146; rs17433234; rs17486038; rs1044553; rs3118635; rs1127927; rs1044554; rs3184394; rs1044560; rs17508708; rs17486059; rs11559172; rs17508701; rs17455684; rs34939838; rs2768629; rs34873985; rs12350395; rs17508605; rs34349125; rs17508668; rs17481644; rs17486178; rs17486192; rs17508577; rs17508675; rs17459128; rs10988207; rs17433297; rs17433262; rs3780689; rs36193924; rs2182730; rs4837336; rs10549379; rs17486073; rs17459135; rs17486185; rs36010531; rs34018398; rs17486136; rs3896405; rs35228713; rs719494; rs11397782; rs17508598; rs17481631; rs1410014; rs4837338; rs17459142; rs4080490; rs17508654; rs17459121; rs3118636; rs17486094; rs1410015; rs17486164; rs17508647; rs17481638; rs17508695; rs17455705; rs17508689; rs3118637; rs12336784; rs3750337; rs10988208; rs17455698; rs11314279; rs41276750; rs10988201; rs7042713; rs34420023; rs12341709; rs17508509; rs3124497; rs28365572; rs17455671; rs17455678; rs35668864; rs17508523; rs34313463; rs35783610; rs10760588; rs10819464; rs10819469; rs10988209; rs11564083; rs11564084; rs11564085; rs11564095; rs12006010; rs12337663; rs12342022; rs12342339; rs17486220; rs2274475; rs2541162; rs2541163; rs2541164; rs2541165; rs3118624; rs3118625; rs3118626; rs3124501; rs3124502; rs3124503; rs3739843; rs3750335; rs3750336; rs3814492; rs3824536; rs6478861; rs6478864; rs7024821; rs7033128; rs7038362; rs7042563; rs7046842; rs7046961; rs7849160; rs7849270; rs7859344; rs7865067

# Metabolic_Enzyme_2_General_References:
7829107; 7945262

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5335

# Metabolic_Enzyme_3_Name:
Short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_3_Synonyms:
SCAD; Butyryl-CoA dehydrogenase

# Metabolic_Enzyme_3_Gene_Name:
ACADS

# Metabolic_Enzyme_3_Protein_Sequence:
>Shortchain specific acylCoA dehydrogenase, mitochondrial precursor
MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQV
DKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNN
SLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLN
GTKAWITNAWEASAAVVFASTDRALQNKGISAFLVPMPTPGLTLGKKEDKLGIRGSSTAN
LIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAF
GAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAIS
HQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS

# Metabolic_Enzyme_3_Number_of_Residues:
412

# Metabolic_Enzyme_3_Molecular_Weight:
44298

# Metabolic_Enzyme_3_Theoretical_pI:
8.12

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-CH group of donors
Function:  acyl-CoA dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor

# Metabolic_Enzyme_3_Pathway:
map00071  Fatty acid metabolism;
 map00280  Valine, leucine and isoleucine degradation;
 map00650  Butanoate metabolism

# Metabolic_Enzyme_3_Reaction:
butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00441:Acyl-CoA_dh_1;
PF02770:Acyl-CoA_dh_M;
PF02771:Acyl-CoA_dh_N

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.3.99.2

# Metabolic_Enzyme_3_GenBank_ID_Protein:
337928

# Metabolic_Enzyme_3_SwissProt_ID:
ACADS_HUMAN (P16219)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ACADS

# Metabolic_Enzyme_3_Geneatlas_id:
ACADS

# Metabolic_Enzyme_3_hgnc_id:
HGNC:90

# Metabolic_Enzyme_3_PDB_ID:
1JQI

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_3_Gene_Sequence:
>1239 bp
ATGGCCGCCGCGCTGCTCGCCCGGGCCTCGGGCCCTGCCCGCAGAGCTCTCTGTCCTAGG
GCCTGGCGGCAGTTACACACCATCTACCAGTCTGTGGAACTGCCCGAGACACACCAGATG
TTGCTCCAGACATGCCGGGACTTTGCCGAGAAGGAGTTGTTTCCCATTGCAGCCCAGGTG
GATAAGGAACATCTCTTCCCAGCGGCTCAGGTGAAGAAGATGGGCGGGCTTGGGCTTCTG
GCCATGGACGTGCCCGAGGAGCTTGGCGGTGCTGGCCTCGATTACCTGGCCTACGCCATC
GCCATGGAGGAGATCAGCCGTGGCTGCGCCTCCACCGGAGTCATCATGAGTGTCAACAAC
TCTCTCTACCTGGGGCCCATCTTGAAGTTTGGCTCCAAGGAGCAGAAGCAGGCGTGGGTC
ACGCCTTTCACCAGTGGTGACAAAATTGGCTGCTTTGCCCTCAGCGAACCAGGGAACGGC
AGTGATGCAGGAGCTGCGTCCACCACCGCCCGGGCCGAGGGCGACTCATGGGTTCTGAAT
GGAACCAAAGCCTGGATCACCAATGCCTGGGAGGCTTCGGCTGCCGTGGTCTTTGCCAGC
ACGGACAGAGCCCTGCAAAACAAGGGCATCAGTGCCTTCCTGGTCCCCATGCCAACGCCT
GGGCTCACGTTGGGGAAGAAAGAAGACAAGCTGGGCATCCGGGGCTCATCCACGGCCAAC
CTCATCTTTGAGGACTGTCGCATCCCCAAGGACAGCATCCTGGGGGAGCCAGGGATGGGC
TTCAAGATAGCCATGCAAACCCTGGACATGGGCCGCATCGGCATCGCCTCCCAGGCCCTG
GGCATTGCCCAGACCGCCCTCGATTGTGCTGTGAACTACGCTGAGAATCGCATGGCCTTC
GGGGCGCCCCTCACCAAGCTCCAGGTCATCCAGTTCAAGTTGGCAGACATGGCCCTGGCC
CTGGAGAGTGCCCGGCTGCTGACCTGGCGCGCTGCCATGCTGAAGGATAACAAGAAGCCT
TTCATCAAGGAGGCAGCCATGGCCAAGCTGGCCGCCTCGGAGGCCGCGACCGCCATCAGC
CACCAGGCCATCCAGATCCTGGGCGGCATGGGCTACGTGACAGAGATGCCGGCAGAGCGG
CACTACCGCGACGCCCGCATCACTGAGATCTACGAGGGCACCAGCGAAATCCAGCGGCTG
GTGATCGCCGGGCATCTGCTCAGGAGCTACCGGAGCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M26393

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_3_Locus:
12q22-qter

# Metabolic_Enzyme_3_SNPs:
rs1799958; rs35233375; rs1800556; rs3914; rs3915; rs2239686; rs2229534; rs9204; rs2229533; rs3916; rs628909; rs639667; rs11065238; rs487915; rs10849781; rs555404; rs11065230; rs695950; rs3999408; rs3794215; rs3794214; rs12231499; rs558314; rs2014355; rs12425598; rs696339; rs696340; rs11065229; rs2071266; rs7978125; rs708783; rs11614958; rs7303474; rs12369156; rs7312316; rs575437; rs2948149; rs658521; rs2239760; rs7303170; rs3021338; rs3021337; rs2239758; rs2239759; rs644065; rs28940872; rs17848085; rs28940875; rs28940874; rs28941773; rs550921; rs697853; rs17848089; rs11065232; rs2239687; rs10716885; rs11359512; rs3794216; rs12315099; rs708781; rs11405010; rs11065236; rs12819675; rs11065231; rs7312665; rs648979; rs11065235; rs34346357; rs10570826; rs36103003; rs35503787; rs35084008; rs11065234; rs3838807; rs7957395; rs3021336; rs17848090; rs34491494; rs4420355; rs34673751; rs34601782; rs12368617; rs11065237; rs34683471; rs12306196; rs4767928; rs11065233; rs12821230; rs34289241; rs17848083; rs17848081; rs17848082; rs11065228; rs11065227; rs1055059; rs1055070; rs10849780; rs11065240; rs11065241; rs11065243; rs11065244; rs11834085; rs12322777; rs12825376; rs17848088; rs2066938; rs2239757; rs2948150; rs34030695; rs34280477; rs34708625; rs35360964; rs35771722; rs3830155; rs476676; rs509152; rs510900; rs512732; rs6490302; rs649622; rs696335; rs696336; rs696337; rs696338

# Metabolic_Enzyme_3_General_References:
2565344; 9383286; 1286669; 1692038; 9499414; 11134486

# Metabolic_Enzyme_3_References:
15535801; 15670663

# Metabolic_Enzyme_4_ID:
5546

# Metabolic_Enzyme_4_Name:
Carnitine O-palmitoyltransferase 2, mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
Carnitine palmitoyltransferase II; CPT II

# Metabolic_Enzyme_4_Gene_Name:
CPT2

# Metabolic_Enzyme_4_Protein_Sequence:
>Carnitine Opalmitoyltransferase 2, mitochondrial precursor
MVPRLLLRAWPRGPAVGPGAPSRPLSAGSGPGQYLQRSIVPTMHYQDSLPRLPIPKLEDT
IRRYLSAQKPLLNDGQFRKTEQFCKSFENGIGKELHEQLVALDKQNKHTSYISGPWFDMY
LSARDSVVLNFNPFMAFNPDPKSEYNDQLTRATNMTVSAIRFLKTLRAGLLEPEVFHLNP
AKSDTITFKRLIRFVPSSLSWYGAYLVNAYPLDMSQYFRLFNSTRLPKPSRDELFTDDKA
RHLLVLRKGNFYIFDVLDQDGNIVSPSEIQAHLKYILSDSSPAPEFPLAYLTSENRDIWA
ELRQKLMSSGNEESLRKVDSAVFCLCLDDFPIKDLVHLSHNMLHGDGTNRWFDKSFNLII
AKDGSTAVHFEHSWGDGVAVLRFFNEVFKDSTQTPAVTPQSQPATTDSTVTVQKLNFELT
DALKTGITAAKEKFDATMKTLTIDCVQFQRGGKEFLKKQKLSPDAVAQLAFQMAFLRQYG
QTVATYESCSTAAFKHGRTETIRPASVYTKRCSEAFVREPSRHSAGELQQMMVECSKYHG
QLTKEAAMGQGFDRHLFALRHLAAAKGIILPELYLDPAYGQINHNVLSTSTLSSPAVNLG
GFAPVVSDGFGVGYAVHDNWIGCNVSSYPGRNAREFLQCVEKALEDMFDALEGKSIKS

# Metabolic_Enzyme_4_Number_of_Residues:
658

# Metabolic_Enzyme_4_Molecular_Weight:
73778

# Metabolic_Enzyme_4_Theoretical_pI:
8.30

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Palmitoyl-CoA + L-carnitine = CoA + L- palmitoylcarnitine

# Metabolic_Enzyme_4_Pathway:
map00071  Fatty acid metabolism

# Metabolic_Enzyme_4_Reaction:
palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00755:Carn_acyltransf

# Metabolic_Enzyme_4_Signals:
1-15

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.3.1.21

# Metabolic_Enzyme_4_GenBank_ID_Protein:
1041195

# Metabolic_Enzyme_4_SwissProt_ID:
CPT2_HUMAN (P23786)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CPT2

# Metabolic_Enzyme_4_Geneatlas_id:
CPT2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:2330

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane

# Metabolic_Enzyme_4_Gene_Sequence:
>1977 bp
ATGGTGCCCCGCCTGCTGCTGCGCGCCTGGCCCCGGGGCCCCGCGGTTGGTCCGGGAGCC
CCCAGTCGGCCCCTCAGCGCCGGCTCCGGGCCCGGCCAGTACCTGCAGCGCAGCATCGTG
CCCACCATGCACTACCAGGACAGCCTGCCCAGGCTGCCTATTCCCAAACTTGAAGACACC
ATTAGGAGATACCTCAGTGCACAGAAGCCTCTCTTGAATGATGGCCAGTTCAGGAAAACA
GAACAATTTTGCAAGAGTTTTGAAAATGGGATTGGAAAAGAACTGCATGAGCAGCTGGTT
GCTCTGGACAAACAGAATAAACATACAAGCTACATTTCGGGACCCTGGTTTGATATGTAC
CTATCTGCTCGAGACTCCGTTGTTCTGAACTTTAATCCATTTATGGCTTTCAATCCTGAC
CCAAAATCTGAGTATAATGACCAGCTCACCCGGGCAACCAACATGACTGTTTCTGCCATC
CGGTTTCTGAAGACACTCCGGGCTGGCCTTCTGGAGCCAGAAGTGTTCCACTTGAACCCT
GCAAAAAGTGACACTATCACCTTCAAGAGACTCATACGCTTTGTGCCTTCCTCTCTGTCC
TGGTATGGGGCCTACCTGGTCAATGCGTATCCCCTGGATATGTCCCAGTATTTTCGGCTT
TTCAACTCAACTCGTTTACCCAAACCCAGTCGGGATGAACTCTTCACTGATGACAAGGCC
AGACACCTCCTGGTCCTAAGGAAAGGAAATTTTTATATCTTTGATGTCCTGGATCAAGAT
GGGAACATTGTGAGCCCCTCGGAAATCCAGGCACATCTGAAGTACATTCTCTCAGACAGC
AGCCCCGCCCCCGAGTTTCCCCTGGCATACCTGACCAGTGAGAACCGAGACATCTGGGCA
GAGCTCAGGCAGAAGCTGATGAGTAGTGGCAATGAGGAGAGCCTGAGGAAAGTGGACTCG
GCAGTGTTCTGTCTCTGCCTAGATGACTTCCCCATTAAGGACCTTGTCCACTTGTCCCAC
AATATGCTGCATGGGGATGGCACAAACCGCTGGTTTGATAAATCCTTTAACCTCATTATC
GCCAAGGATGGCTCTACTGCCGTCCACTTTGAGCACTCTTGGGGTGATGGTGTGGCAGTG
CTCAGATTTTTTAATGAAGTATTTAAAGACAGCACTCAGACCCCTGCCGTCACTCCACAG
AGCCAGCCAGCTACCACTGACTCTACTGTCACGGTGCAGAAACTCAACTTCGAGCTGACT
GATGCCTTAAAGACTGGCATCACAGCTGCTAAGGAAAAGTTTGATGCCACCATGAAAACC
CTCACTATTGACTGCGTCCAGTTTCAGAGAGGAGGCAAAGAATTCCTGAAGAAGCAAAAG
CTGAGCCCTGACGCAGTTGCCCAGCTGGCATTCCAGATGGCCTTCCTGCGGCAGTACGGG
CAGACAGTGGCCACCTACGAGTCCTGTAGCACTGCCGCATTCAAGCACGGCCGCACTGAG
ACCATCCGCCCGGCCTCCGTCTATACAAAGAGGTGCTCTGAGGCCTTTGTCAGGGAGCCC
TCCAGGCACAGTGCTGGTGAGCTTCAGCAGATGATGGTTGAGTGCTCCAAGTACCATGGC
CAGCTGACCAAAGAAGCAGCAATGGGCCAGGGCTTTGACCGACACTTGTTTGCTCTGCGG
CATCTGGCAGCAGCCAAAGGGATCATCTTGCCTGAGCTCTACCTGGACCCTGCATACGGG
CAGATAAACCACAATGTCCTGTCCACGAGCACACTGAGCAGCCCAGCAGTGAACCTTGGG
GGCTTTGCCCCTGTGGTCTCTGATGGCTTTGGTGTTGGGTATGCTGTTCATGACAACTGG
ATAGGCTGCAATGTCTCTTCCTACCCAGGCCGCAATGCCCGGGAGTTTCTCCAATGTGTG
GAGAAGGCCTTAGAAGACATGTTTGATGCCTTAGAAGGCAAATCCATCAAAAGTTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
U09648

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_4_Locus:
1p32

# Metabolic_Enzyme_4_SNPs:
rs1799821; rs2229291; rs1799822; rs2046138; rs737464; rs3766759; rs12754957; rs11578832; rs6692897; rs3766757; rs11581518; rs12058755; rs3766760; rs370493; rs12737375; rs729227; rs2062015; rs7539949; rs11206125; rs12403153; rs7554022; rs11206124; rs10888776; rs28936673; rs1871748; rs28936674; rs17848485; rs2229292; rs2929073; rs7545725; rs17848481; rs2127879; rs35539736; rs3766761; rs6669426; rs34032280; rs10651054; rs35615594; rs11441059; rs34546584; rs41294754; rs17856060; rs28749333; rs1072706; rs10700582; rs35567339; rs12117467; rs34661224; rs12072546; rs35891200; rs35237240; rs1056396; rs1056397; rs1056425; rs1134688; rs12140585; rs12567834; rs1679913; rs17108139; rs17108140; rs17369394; rs2275088; rs2297664; rs2929074; rs3014991; rs35027235; rs35316080; rs3736118; rs436887; rs6663121; rs6676576; rs6696436; rs7549319

# Metabolic_Enzyme_4_General_References:
1988962; 1961767; 7711730; 2174799; 1528846; 8358442; 8651281; 9600456; 10090476

# Metabolic_Enzyme_4_References:
11788422; 11799139; 11912554; 12060712

# Metabolic_Enzyme_5_ID:
7434

# Metabolic_Enzyme_5_Name:
Caspase-3 precursor

# Metabolic_Enzyme_5_Synonyms:
CASP-3; Apopain; Cysteine protease CPP32; Yama protein; CPP-32; SREBP cleavage activity 1; SCA-1[Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]

# Metabolic_Enzyme_5_Gene_Name:
CASP3

# Metabolic_Enzyme_5_Protein_Sequence:
>Caspase3 precursor
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

# Metabolic_Enzyme_5_Number_of_Residues:
277

# Metabolic_Enzyme_5_Molecular_Weight:
31608

# Metabolic_Enzyme_5_Theoretical_pI:
6.51

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  cysteine-type endopeptidase activity
Function:  caspase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin

# Metabolic_Enzyme_5_Pathway:
Not Available

# Metabolic_Enzyme_5_Reaction:
Not Available

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00656:Peptidase_C14

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.4.22.56

# Metabolic_Enzyme_5_GenBank_ID_Protein:
561666

# Metabolic_Enzyme_5_SwissProt_ID:
CASP3_HUMAN (P42574)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
CASP3

# Metabolic_Enzyme_5_Geneatlas_id:
CASP3

# Metabolic_Enzyme_5_hgnc_id:
HGNC:1504

# Metabolic_Enzyme_5_PDB_ID:
1CP3

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>834 bp
ATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATC
ATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGAT
TATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGA
ATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAAC
TTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATG
CGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGC
CATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACA
AACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATT
CAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGAT
GACATGGCGTGTCATAAAATACCAGTGGATGCCGACTTCTTGTATGCATACTCCACAGCA
CCTGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGT
GCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAAC
CGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAA
CAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U13737

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_5_Locus:
4q34

# Metabolic_Enzyme_5_SNPs:
rs35578277; rs1049210; rs35566035; rs1049253; rs2720378; rs3087455; rs6948; rs4647640; rs4647610; rs4647617; rs4647642; rs4647634; rs4647611; rs4647620; rs1049216; rs4647641; rs4647618; rs4647609; rs4647694; rs8549; rs4647698; rs4647614; rs4647621; rs4647622; rs4647616; rs4647633; rs4647643; rs4647630; rs34184817; rs4647647; rs35422505; rs4647624; rs4647626; rs4647696; rs4647606; rs4647631; rs4647646; rs4647607; rs4647625; rs34022730; rs35439719; rs2720377; rs4647632; rs4647628; rs2310103; rs34309992; rs4647629; rs4647644; rs4647636; rs2019978; rs2705891; rs1830254; rs2720376; rs2696056; rs4241793; rs4647667; rs4647688; rs4647663; rs1405942; rs4647652; rs1405938; rs4647662; rs2705901; rs1405944; rs4647671; rs4647665; rs2696057; rs4647693; rs4647672; rs2705897; rs4647669; rs4647673; rs4647692; rs4647674; rs4647666; rs4647686; rs4647683; rs4647690; rs4647657; rs4987118; rs4647679; rs4647670; rs4987119; rs4647658; rs4647684; rs4647675; rs4647650; rs34319440; rs4647685; rs2696048; rs4647651; rs4647676; rs4647687; rs4647655; rs13128316; rs13435139; rs4647704; rs4647700; rs12646257; rs4647701; rs4647623; rs4647635; rs10028033; rs12641602; rs13101834; rs11380373; rs4647695; rs34119644; rs2705892; rs34858791; rs35063555; rs4647699; rs4647639; rs34095700; rs4647619; rs13102911; rs4647645; rs4647612; rs13101835; rs4647637; rs4647638; rs2705893; rs4647649; rs2696060; rs10028034; rs4647697; rs4647613; rs35978407; rs4647608; rs4647615; rs28418774; rs4647648; rs1802667; rs34568867; rs7442206; rs4647682; rs4647656; rs4647681; rs4647668; rs4647677; rs4647678; rs4647691; rs35261594; rs4647689; rs4647653; rs35966919; rs34740772; rs4647659; rs41314884; rs9997231; rs3215361; rs4647661; rs4647654; rs10014306; rs10660141; rs4647664; rs4647660; rs4647680; rs10034836; rs35094553; rs9715122; rs4647705; rs34083547; rs9715863; rs4647702; rs4647703; rs11930666; rs12108497; rs12507711; rs13108061; rs13435890; rs1405937; rs2696058; rs2696059; rs2705881; rs2705882; rs2705900; rs2720388; rs2720389; rs34605630; rs4647600; rs4647602; rs4647603; rs4647605; rs4861629; rs4862396; rs4862399; rs7673753; rs7674164; rs7687648; rs9685847

# Metabolic_Enzyme_5_General_References:
7983002; 7774019; 7596430; 8673606; 9045680; 10821855; 8755496; 8696339

# Metabolic_Enzyme_5_References:
12684680; 14654989; 16328043

# Metabolic_Enzyme_6_ID:
5544

# Metabolic_Enzyme_6_Name:
Carnitine O-palmitoyltransferase I, liver isoform

# Metabolic_Enzyme_6_Synonyms:
CPT I; CPTI-L; Carnitine palmitoyltransferase 1A

# Metabolic_Enzyme_6_Gene_Name:
CPT1A

# Metabolic_Enzyme_6_Protein_Sequence:
>Carnitine Opalmitoyltransferase I, liver isoform
MAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFIRFKNGIITGVYPASPS
SWLIVVVGVMTTMYAKIDPSLGIIAKINRTLETANCMSSQTKNVVSGVLFGTGLWVALIV
TMRYSLKVLLSYHGWMFTEHGKMSRATKIWMGMVKIFSGRKPMLYSFQTSLPRLPVPAVK
DTVNRYLQSVRPLMKEEDFKRMTALAQDFAVGLGPRLQWYLKLKSWWATNYVSDWWEEYI
YLRGRGPLMVNSNYYAMDLLYILPTHIQAARAGNAIHAILLYRRKLDREEIKPIRLLGST
IPLCSAQWERMFNTSRIPGEETDTIQHMRDSKHIVVYHRGRYFKVWLYHDGRLLKPREME
QQMQRILDNTSEPQPGEARLAALTAGDRVPWARCRQAYFGRGKNKQSLDAVEKAAFFVTL
DETEEGYRSEDPDTSMDSYAKSLLHGRCYDRWFDKSFTFVVFKNGKMGLNAEHSWADAPI
VAHLWEYVMSIDSLQLGYAEDGHCKGDINPNIPYPTRLQWDIPGECQEVIETSLNTANLL
ANDVDFHSFPFVAFGKGIIKKCRTSPDAFVQLALQLAHYKDMGKFCLTYEASMTRLFREG
RTETVRSCTTESCDFVRAMVDPAQTVEQRLKLFKLASEKHQHMYRLAMTGSGIDRHLFCL
YVVSKYLAVESPFLKEVLSEPWRLSTSQTPQQQVELFDLENNPEYVSSGGGFGPVADDGY
GVSYILVGENLINFHISSKFSCPETDSHRFGRHLKEAMTDIITLFGLSSNSKK

# Metabolic_Enzyme_6_Number_of_Residues:
773

# Metabolic_Enzyme_6_Molecular_Weight:
88369

# Metabolic_Enzyme_6_Theoretical_pI:
8.84

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Palmitoyl-CoA + L-carnitine = CoA + L- palmitoylcarnitine

# Metabolic_Enzyme_6_Pathway:
map00071  Fatty acid metabolism

# Metabolic_Enzyme_6_Reaction:
palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00755:Carn_acyltransf

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
48-73
103-122

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.3.1.21

# Metabolic_Enzyme_6_GenBank_ID_Protein:
755646

# Metabolic_Enzyme_6_SwissProt_ID:
CPT1A_HUMAN (P50416)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
CPT1A

# Metabolic_Enzyme_6_Geneatlas_id:
CPT1A

# Metabolic_Enzyme_6_hgnc_id:
HGNC:2328

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; multi-pass membrane protein

# Metabolic_Enzyme_6_Gene_Sequence:
>2322 bp
ATGGCAGAAGCTCACCAAGCTGTGGCCTTTCAGTTCACGGTCACTCCGGACGGGATTGAC
CTGCGGCTGAGCCATGAAGCTCTTAGACAAATCTATCTCTCTGGACTTCATTCCTGGAAA
AAGAAGTTCATCAGATTCAAGAACGGCATCATCACTGGCGTGTACCCGGCAAGCCCCTCC
AGTTGGCTTATCGTGGTGGTGGGCGTGATGACAACGATGTACGCCAAGATCGACCCCTCG
TTAGGAATAATTGCAAAAATCAATCGGACTCTGGAAACGGCCAACTGCATGTCCAGCCAG
ACGAAGAACGTGGTCAGCGGCGTGCTGTTTGGCACCGGCCTGTGGGTGGCCCTCATCGTC
ACCATGCGCTACTCCCTGAAAGTGCTGCTCTCCTACCACGGGTGGATGTTCACTGAGCAC
GGCAAGATGAGTCGTGCCACCAAGATCTGGATGGGTATGGTCAAGATCTTTTCAGGCCGA
AAACCCATGTTGTACAGCTTCCAGACATCGCTGCCTCGCCTGCCGGTCCCGGCTGTCAAA
GACACTGTGAACAGGTATCTACAGTCGGTGAGGCCTCTTATGAAGGAAGAAGACTTCAAA
CGGATGACAGCACTTGCTCAAGATTTTGCTGTCGGTCTTGGACCAAGATTACAGTGGTAT
TTGAAGTTAAAATCCTGGTGGGCTACAAATTACGTGAGCGACTGGTGGGAGGAGTACATC
TACCTCCGAGGACGAGGGCCGCTCATGGTGAACAGCAACTATTATGCCATGGATCTGCTG
TATATCCTTCCAACTCACATTCAGGCAGCAAGAGCCGGCAACGCCATCCATGCCATCCTG
CTTTACAGGCGCAAACTGGACCGGGAGGAAATCAAACCAATTCGTCTTTTGGGATCCACG
ATTCCACTCTGCTCCGCTCAGTGGGAGCGGATGTTTAATACTTCCCGGATCCCAGGAGAG
GAGACAGACACCATCCAGCACATGAGAGACAGCAAGCACATCGTCGTGTACCATCGAGGA
CGCTACTTCAAGGTCTGGCTCTACCATGATGGGCGGCTGCTGAAGCCCCGGGAGATGGAG
CAGCAGATGCAGAGGATCCTGGACAATACCTCGGAGCCTCAGCCCGGGGAGGCCAGGCTG
GCAGCCCTCACCGCAGGAGACAGAGTTCCCTGGGCCAGGTGTCGTCAGGCCTATTTTGGA
CGTGGGAAAAATAAGCAGTCTCTTGATGCTGTGGAGAAAGCAGCGTTCTTCGTGACGTTA
GATGAAACTGAAGAAGGATACAGAAGTGAAGACCCGGATACGTCAATGGACAGCTACGCC
AAATCTCTACTACACGGCCGATGTTACGACAGGTGGTTTGACAAGTCGTTCACGTTTGTT
GTCTTCAAAAACGGGAAGATGGGCCTCAACGCTGAACACTCCTGGGCAGATGCGCAGATC
GTGGCCCACCTTTGGGAGTACGTCATGTCCATTGACAGCCTCCAGCTGGGCTATGCGGAG
GATGGGCACTGCAAAGGCGACATCAATCCGAACATTCCGTACCCCACCAGGCTGCAGTGG
GACATCCCGGGGGAATGTCAAGAGGTTATAGAGACCTCCCTGAACACCGCAAATCTTCTG
GCAAACGACGTGGATTTCCATTCCTTCCCATTCGTAGCCTTTGGTAAAGGAATCATCAAG
AAATGTCGCACGAGCCCAGACACCTTTGTGCAGCTGGCCCTCCAGCTGGCGCACTACAAG
GACATGGGCAAGTTTTGCCTCACATACGAGGCCTCCATGACCCGGCTCTTCCGAGAGGGG
AGGACGGAGACCGTGCGCTCCTGCACCACTGAGTCATGCGACTTCGTGCGGGCCATGGTG
GACCCGGCCCAGACGGTGGAACAGAGGCTGAAGTTGTTCAAGTTGGCGTCTGAGAAGCAT
CAGCATATGTATCGCCTCGCCATGACCGGCTCTGGGATCGATCGTCACCTCTTCTGCCTT
TACGTGGTGTCTAAATATCTCGCTGTGGAGTCCCCTTTCCTTAAGGAAGTTTTATCTGAG
CCTTGGAGATTATCAACAAGCCAGACCCCTCAGCAGCAAGTGGAGCTGTTTGACTTGGAG
AATAACCCAGAGTACGTGTCCAGCGGAGGGGGCTTTGGACCGGTTGCTGATGACGGCTAT
GGTGTGTCGTACATCCTTGTGGGAGAGAACCTCATCAATTTCCACATTTCTTCCAAGTTC
TCTTGCCCTGAGACGGATTCTCATCGCTTTGGAAGGCACCTGAAAGAAGCAATGACTGAC
ATCATCACTTTGTTTGGTCTCAGTTCTAATTCCAAAAAGTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
L39211

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_6_Locus:
11q13.1-q13.2

# Metabolic_Enzyme_6_SNPs:
rs17610395; rs2228502; rs628399; rs1017639; rs3019613; rs2924697; rs1017640; rs597539; rs11228377; rs11228372; rs3019607; rs7938117; rs3019614; rs10896371; rs3019594; rs4930614; rs11228368; rs11228374; rs2924695; rs4930617; rs1108714; rs1017641; rs643112; rs2003892; rs879784; rs4930616; rs7943745; rs10896370; rs10896369; rs12365850; rs11228373; rs644389; rs2924689; rs36105428; rs11822229; rs12361365; rs10896372; rs10792000; rs879783; rs3019611; rs613084; rs3019606; rs10459022; rs11228364; rs3019605; rs11605837; rs11228371; rs4930618; rs12283159; rs11827531; rs3019612; rs593062; rs11228376; rs11228369; rs11825726; rs11228370; rs3019608; rs7126202; rs897047; rs2123869; rs897049; rs4930610; rs3019578; rs7112896; rs7126594; rs3019587; rs1037488; rs3019598; rs7105481; rs2085062; rs7102159; rs6591353; rs3829242; rs4930248; rs3763836; rs7948344; rs732852; rs3019582; rs3794020; rs2278908; rs6591354; rs10896368; rs3763831; rs2924677; rs10791999; rs11228358; rs2305507; rs897048; rs11828477; rs2924674; rs2060981; rs11228357; rs3019597; rs2924682; rs2305508; rs1840272; rs6591355; rs747840; rs2924700; rs7942147; rs732853; rs3019603; rs4930608; rs6591356; rs3019581; rs2278906; rs11827126; rs11825304; rs4930250; rs3019604; rs3019585; rs12575292; rs11607771; rs4930247; rs11228351; rs2924687; rs11228346; rs2060980; rs4930249; rs7119078; rs11228354; rs11228341; rs7112615; rs2085063; rs4930613; rs7129243; rs2924678; rs11228359; rs2924671; rs11228349; rs12364396; rs2924675; rs3019590; rs2924685; rs11822212; rs12273177; rs4930609; rs7928089; rs10791997; rs3019576; rs7934156; rs4930612; rs2924672; rs7104634; rs7117668; rs2924679; rs3019599; rs2924683; rs3794021; rs3019584; rs7926742; rs11228350; rs3019593; rs9704703; rs2924692; rs2278907; rs10791998; rs3763830; rs597316; rs7131462; rs4584583; rs3922501; rs1046804; rs41302429; rs11228356; rs3019610; rs12364665; rs12283670; rs583914; rs641302; rs34727673; rs5792455; rs34595037; rs35634010; rs11228375; rs34794325; rs12364259; rs7482525; rs34314249; rs11418561; rs12272547; rs35006871; rs34763278; rs35467950; rs5792454; rs12801913; rs4930619; rs35195021; rs12793416; rs11828395; rs10633712; rs593064; rs35472359; rs35234753; rs34854628; rs12364691; rs34758497; rs3019609; rs12283783; rs12283727; rs11821979; rs34429633; rs12292255; rs35819630; rs34404058; rs12290497; rs2924691; rs7480689; rs11228367; rs12788142; rs35586360; rs10688362; rs36108814; rs2924696; rs34656095; rs3019615; rs12283144; rs35627517; rs35518321; rs12290326; rs34175092; rs12803116; rs35820230; rs36211044; rs673059; rs11228379; rs2924694; rs12283786; rs641304; rs7483929; rs11372679; rs5792452; rs609983; rs12283787; rs35956171; rs656569; rs11228363; rs35029230; rs1993277; rs2924690; rs34222279; rs12272381; rs34106250; rs34882695; rs34752141; rs35428930; rs35190628; rs11228378; rs28706864; rs12290603; rs12793100; rs2924698; rs11821572; rs35786597; rs17848444; rs36037833; rs34772073; rs35269495; rs34276531; rs897046; rs34480858; rs5792453; rs36030703; rs4261294; rs35703107; rs17848445; rs4408320; rs11228361; rs17848452; rs33981601; rs12421861; rs41302431; rs10551845; rs11827064; rs5792450; rs2924670; rs3019595; rs36152240; rs1809153; rs10614870; rs12225347; rs12788900; rs34450025; rs11312962; rs10561732; rs7944039; rs17848449; rs10160644; rs11301758; rs1840273; rs34991663; rs12277917; rs11416327; rs11420370; rs12293710; rs12416862; rs12808840; rs35804809; rs2924681; rs12274770; rs2375867; rs36010265; rs35948154; rs35597245; rs3019596; rs35593953; rs35803657; rs12808833; rs34326931; rs2924684; rs11823947; rs12790880; rs7942391; rs10591978; rs34884968; rs10676288; rs35999790; rs11311321; rs12802903; rs35099183; rs12282676; rs11306055; rs33977467; rs5792451; rs10561780; rs35513013; rs3019577; rs2924680; rs11228345; rs3019591; rs12363334; rs11228340; rs3019602; rs11443873; rs4930611; rs3019601; rs11365149; rs3763834; rs35497430; rs35857185; rs11601427; rs3019575; rs11328803; rs10590789; rs7948837; rs35232106; rs11228348; rs10160686; rs7951987; rs10657961; rs7925592; rs35033163; rs2924699; rs11228353; rs11419131; rs2924693; rs17848439; rs3019592; rs34829139; rs2924688; rs7924951; rs2278905; rs11311322; rs3083118; rs33998161; rs35483425; rs3019580; rs3019600; rs2060979; rs34370352; rs35967738; rs11400593; rs3019579; rs35816594; rs35947002; rs11376032; rs35323274; rs11228343; rs35574171; rs11413406; rs11423981; rs17848451; rs3763835; rs35363406; rs17848446; rs34324238; rs7943886; rs2924676; rs11826977; rs34100447; rs1840271; rs3083115; rs34518934; rs34605091; rs11228352; rs35591039; rs34325048; rs11228342; rs7108728; rs11333511; rs7111658; rs35809934; rs11323138; rs35401315; rs11228362; rs34756817; rs12808271; rs12808487; rs34198180; rs3018712; rs35128171; rs35985228; rs10791994; rs10896364; rs10896365; rs11825731; rs12365708; rs2060982; rs2508848; rs3019583; rs36118833; rs483148; rs4930606; rs678904; rs679596; rs7110940; rs7941385; rs7948522

# Metabolic_Enzyme_6_General_References:
7892212

# Metabolic_Enzyme_6_References:
11799139; 11912554; 12705401; 15647998

# Macromolecular_Interacting_Partner_1_ID:
6935

# Macromolecular_Interacting_Partner_1_Name:
Organic cation/carnitine transporter 2

# Macromolecular_Interacting_Partner_1_Synonyms:
Solute carrier family 22 member 5; High-affinity sodium-dependent carnitine cotransporter

# Macromolecular_Interacting_Partner_1_Gene_Name:
SLC22A5

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Organic cation/carnitine transporter 2
MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS
AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS
QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQ
TGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYA
FGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKA
AKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFG
LSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLV
PPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF
VYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTR
MLKDGQERPTILKSTAF

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
557

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
62753

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
8.04

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  ion transporter activity
Function:  transporter activity
 ||
>>>
Process:  ion transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also Relative uptake activity ratio of carnitine to TEA is 11.3

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF07690:MFS_1

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
21-41
143-163
173-193
198-218
233-253
258-278
342-362
374-394
407-427
431-451
463-483
489-509

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
3273741

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
S22A5_HUMAN (O76082)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
SLC22A5

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
SLC22A5

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:10969

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1674 bp
ATGCGGGACTACGACGAGGTGACCGCCTTCCTGGGCGAGTGGGGGCCCTTCCAGCGCCTC
ATCTTCTTCCTGCTCAGCGCCAGCATCATCCCCAATGGCTTCACCGGCCTGTCCTCCGTG
TTCCTGATAGCGACCCCGGAGCACCGCTGCCGGGTGCCGGACGCCGCGAACCTGAGCAGC
GCCTGGCGCAACCACACTGTCCCACTGCGGCTGCGGGACGGCCGCGAGGTGCCCCACAGC
TGCCGCCGCTACCGGCTCGCCACCATCGCCAACTTCTCGGCGCTCGGGCTGGAGCCGGGG
CGCGACGTGGACCTGGGGCAGCTGGAGCAGGAGAGCTGTCTGGATGGCTGGGAGTTCAGT
CAGGACGTCTACCTGTCCACCATTGTGACCGAGTGGAACCTGGTGTGTGAGGACGACTGG
AAGGCCCCACTCACAATCTCCTTGTTCTTCGTGGGTGTGCTGTTGGGCTCCTTCATTTCA
GGGCAGCTGTCAGACAGGTTTGGCCGGAAGAATGTGCTGTTCGTGACCATGGGCATGCAG
ACAGGCTTCAGCTTCCTGCAGATCTTCTCGAAGAATTTTGAGATGTTTGTCGTGCTGTTT
GTCCTTGTAGGCATGGGCCAGATCTCCAACTATGTGGCAGCATTTGTCCTGGGGACAGAA
ATTCTTGGCAAGTCAGTTCGTATAATATTCTCTACGTTAGGAGTGTGCATATTTTATGCA
TTTGGCTACATGGTGCTGCCACTGTTTGCTTACTTCATCCGAGACTGGCGGATGCTGCTG
GTGGCGCTGACGATGCCGGGGGTGCTGTGCGTGGCACTCTGGTGGTTCATCCCTGAGTCC
CCCCGATGGCTCATCTCTCAGGGACGATTTGAAGAGGCAGAGGTGATCATCCGCAAGGCT
GCCAAAGCCAATGGGATTGTTGTGCCTTCCACTATCTTTGACCCGAGTGAGTTACAAGAC
CTAAGTTCCAAGAAGCAACAGTCCCACAACATTCTGGATCTGCTTCGAACCTGGAATATC
CGGATGGTCACCATCATGTCCATAATGCTGTGGATGACCATATCAGTGGGCTATTTTGGG
CTTTCGCTTGATACTCCTAACTTGCATGGGGACATCTTTGTGAACTGCTTCCTTTCAGCG
ATGGTTGAAGTCCCAGCATATGTGTTGGCCTGGCTGCTGCTGCAATATTTGCCCCGGCGC
TATTCCATGGCCACTGCCCTCTTCCTGGGTGGCAGTGTCCTTCTCTTCATGCAGCTGGTA
CCCCCAGACTTGTATTATTTGGCTACAGTCCTGGTGATGGTGGGCAAGTTTGGAGTCACG
GCTGCCTTTTCCATGGTCTACGTGTACACAGCCGAGCTGTATCCCACAGTGGTGAGAAAC
ATGGGTGTGGGAGTCAGCTCCACAGCATCCCGCCTGGGCAGCATCCTGTCTCCCTACTTC
GTTTACCTTGGTGCCTACGACCGCTTCCTGCCCTACATTCTCATGGGAAGTCTGACCATC
CTGACAGCCATCCTCACCTTGTTTCTCCCAGAGAGCTTCGGTACCCCACTCCCAGACACC
ATTGACCAGATGCTAAGAGTCAAAGGAATGAAACACAGAAAAACTCCAAGTCACACAAGG
ATGTTAAAAGATGGTCAAGAAAGGCCCACAATCCTTAAAAGCACAGCCTTCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AF057164

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_1_Locus:
5q31

# Macromolecular_Interacting_Partner_1_SNPs:
rs10040427; rs274558; rs2631365; rs274548; rs1045020; rs274547; rs2631367; rs274554; rs581968; rs274550; rs274557; rs582490; rs2631362; rs2631361; rs274551; rs183898; rs274567; rs2073643; rs11748193; rs274549; rs274561; rs274571; rs11746555; rs7717486; rs10060615; rs274568; rs274562; rs635620; rs671473; rs274566; rs635619; rs274559; rs2631364; rs7731390; rs274560; rs274552; rs2631359; rs4646302; rs10080188; rs2074610; rs2569266; rs274565; rs274563; rs274555; rs2073644; rs4646306; rs2073642; rs3788987; rs611084; rs274572; rs2631360; rs2516788; rs4646301; rs610735; rs3788988; rs17689550; rs4646305; rs274570; rs274553; rs2073645; rs17622208; rs2631371; rs2631372; rs2631370; rs10520126; rs17165938; rs2631369; rs12517950; rs2569265; rs28383482; rs11544587; rs28383480; rs2405518; rs28383481; rs1045019; rs13180169; rs34601011; rs2631366; rs13180043; rs13180295; rs1045018; rs13180186; rs9686866; rs35785385; rs34330304; rs13178567; rs13163451; rs35156209; rs274573; rs34069801; rs34130186; rs35273710; rs2631353; rs274569; rs5871452; rs4646304; rs35964415; rs34741321; rs34052176; rs7705471; rs694546; rs34437551; rs34524757; rs34492944; rs35506003; rs2631363; rs2631354; rs274564; rs13185655; rs13161860; rs34590412; rs200838; rs10677149; rs34143937; rs274556; rs35883519; rs4551059; rs35608101; rs34965096; rs35295663; rs13167994; rs166674; rs33988427; rs35344343; rs34452667; rs35739543; rs583528; rs6897342; rs35758518; rs13187029; rs4646298; rs2631368; rs35323400; rs34786243; rs4646300; rs4646299; rs10515456; rs11568512; rs11568515; rs11568521; rs11568522; rs11568523; rs11568525; rs11739135; rs200837; rs2023912; rs274546; rs35792621; rs367805; rs7705826

# Macromolecular_Interacting_Partner_1_General_References:
9618255; 9685390; 9916797; 10454528; 10425211; 10480371; 10072434; 10545605; 10559218; 10612840; 10679939

# Macromolecular_Interacting_Partner_1_References:
11715001; 11739607; 12084797; 12183691

# Macromolecular_Interacting_Partner_2_ID:
7549

# Macromolecular_Interacting_Partner_2_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
INS

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_2_Signals:
1-24

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
INS

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_2_Locus:
11p15.5

# Macromolecular_Interacting_Partner_2_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_2_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_2_References:
11768245; 12796847; 15479216; 15490412

# Macromolecular_Interacting_Partner_3_ID:
7551

# Macromolecular_Interacting_Partner_3_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_3_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_3_Locus:
6p21.3

# Macromolecular_Interacting_Partner_3_SNPs:
Not Available

# Macromolecular_Interacting_Partner_3_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_3_References:
12162946; 12176737; 12824292

# Macromolecular_Interacting_Partner_4_ID:
7694

# Macromolecular_Interacting_Partner_4_Name:
Peroxisome proliferator-activated receptor alpha

# Macromolecular_Interacting_Partner_4_Synonyms:
PPAR-alpha

# Macromolecular_Interacting_Partner_4_Gene_Name:
PPARA

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Peroxisome proliferatoractivated receptor alpha
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
468

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
52226

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.20

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  steroid hormone receptor activity
Function:  transcription factor activity
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
307341

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
PPARA_HUMAN (Q07869)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
PPARA

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
PPARA

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:9232

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1407 bp
ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAG
AGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGGAAACATCCAAGAGATTTCGCAATCC
ATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT
CCTGGCTCAGATGGCTCGGTCATCACGGACACGCTTTCACCAGCTTCGAGCCCCTCCTCG
GTGACTTATCCTGTGGTCCCCGGCAGCGTGGACGAGTCTCCCAGTGGAGCATTGAACATC
GAATGTAGAATCTGCGGGGACAAGGCCTCAGGCTATCATTACGGAGTCCACGCGTGTGAA
GGCTGCAAGGGCTTCTTTCGGCGAACGATTCGACTCAAGCTGGTGTATGACAAGTGCGAC
CGCAGCTGCAAGATCCAGAAAAAGAACAGAAACAAATGCCAGTATTGTCGATTTCACAAG
TGCCTTTCTGTCGGGATGTCACACAACGCGATTCGTTTTGGACGAATGCCAAGATCTGAG
AAAGCAAAACTGAAAGCAGAAATTCTTACCTGTGAACATGACATAGAAGATTCTGAAACT
GCAGATCTCAAATCTCTGGCCAAGAGAATCTACGAGGCCTACTTGAAGAACTTCAACATG
AACAAGGTCAAAGCCCGGGTCATCCTCTCAGGAAAGGCCAGTAACAATCCACCTTTTGTC
ATACATGATATGGAGACACTGTGTATGGCTGAGAAGACGCTGGTGGCCAAGCTGGTGGCC
AATGGCATCCAGAACAAGGAGGTGGAGGTCCGCATCTTTCACTGCTGCCAGTGCACGTCA
GTGGAGACCGTCACGGAGCTCACGGAATTCGCCAAGGCCATCCCAGCGTTCGCAAACTTG
GACCTGAACGATCAAGTGACATTGCTAAAATACGGAGTTTATGAGGCCATATTCGCCATG
CTGTCTTCTGTGATGAACAAAGACGGGATGCTGGTAGCGTATGGAAATGGGTTTATAACT
CGTGAATTCCTAAAAAGCCTAAGGAAACCGTTCTGTGATATCATGGAACCCAAGTTTGAT
TTTGCCATGAAGTTCAATGCACTGGAACTGGATGACAGTGATATCTCCCTTTTTGTGGCT
GCTATCATTTGCTGTGGAGATCGTCCTGGCCTTCTAAACGTAGGACACATTGAAAAAATG
CAGGAGGGTATTGTACATGTGCTCAGACTCCACCTGCAGAGCAACCACCCGGACGATATC
TTTCTCTTCCCAAAACTTCTTCAAAAAATGGCAGACCTCCGGCAGCTGGTGACGGAGCAT
GCGCAGCTGGTGCAGATCATCAAGAAGACGGAGTCGGATGCTGCGCTGCACCCGCTACTG
CAGGAGATCTACAGGGACATGTACTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
L02932

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_4_Locus:
22q12-q13.1|22q13.31

# Macromolecular_Interacting_Partner_4_SNPs:
rs1800206; rs1800234; rs1800204; rs1800235; rs4253773; rs135547; rs129600; rs4253681; rs4253652; rs135552; rs135539; rs135542; rs4253655; rs12330015; rs9627046; rs135538; rs4253663; rs7364220; rs4253620; rs4253698; rs4253781; rs9626729; rs4253758; rs4253699; rs4253630; rs4253682; rs4253703; rs1555208; rs4253701; rs4253622; rs4253704; rs135549; rs4253665; rs4253686; rs4253792; rs6008259; rs4253702; rs4253669; rs135550; rs135543; rs4253621; rs4253788; rs4253678; rs4253695; rs4253791; rs5769177; rs4253674; rs4253671; rs4253641; rs4253624; rs5766696; rs4253639; rs4253618; rs7286168; rs4253786; rs4253784; rs4253651; rs4253757; rs4253800; rs8138102; rs4253635; rs4253670; rs4253789; rs11704856; rs4253660; rs4253645; rs9626736; rs4253797; rs135540; rs4253638; rs4253694; rs8135690; rs4253633; rs4253627; rs4253642; rs4253696; rs4253656; rs4253706; rs4253659; rs4253672; rs4253691; rs4253667; rs9306498; rs5766698; rs4253688; rs4253623; rs4253634; rs4253801; rs1055659; rs135548; rs4253687; rs4253707; rs4253646; rs6008970; rs4253664; rs4253643; rs4253700; rs4253668; rs135555; rs4253685; rs4253640; rs6008976; rs7287085; rs4253705; rs3892755; rs4253661; rs4253626; rs4253637; rs4253658; rs4253629; rs4253782; rs4253647; rs7289836; rs4253679; rs135551; rs4253793; rs4253617; rs4253692; rs4253631; rs4253644; rs4253625; rs9306499; rs4253790; rs4253787; rs4253683; rs4253619; rs4253662; rs4253657; rs5769178; rs4253756; rs4253684; rs4253636; rs135554; rs4253785; rs4253628; rs9626737; rs4253780; rs4253654; rs4253677; rs761543; rs4253783; rs4253648; rs11704979; rs4253680; rs4253616; rs9626814; rs4253653; rs4253693; rs4253673; rs4253632; rs4253650; rs4253689; rs11913649; rs4253666; rs4823902; rs11704508; rs5769243; rs10427717; rs8135547; rs9680739; rs8139731; rs17661656; rs3747246; rs41367645; rs17661718; rs9306500; rs5766804; rs135553; rs41388244; rs9615264; rs16994933; rs41427746; rs16994915; rs6007981; rs17241878; rs10154348; rs12162684; rs11705154; rs11703495; rs135541; rs12160659; rs7287027; rs4823586; rs6009111; rs41378347; rs12169296; rs135545; rs1134224; rs10775794; rs11703746; rs135536; rs9680676; rs12169290; rs9627268; rs5769366; rs17241885; rs7288994; rs9627100; rs7289495; rs1055657; rs6009081; rs135546; rs1800246; rs5767743; rs4253762; rs4253778; rs4253690; rs4823613; rs4253769; rs4253751; rs6008197; rs6519979; rs4253761; rs4253747; rs4253730; rs4253775; rs4253713; rs4253719; rs4253750; rs4253764; rs4253765; rs4253776; rs4253729; rs4253709; rs4253712; rs4253760; rs4253728; rs11090819; rs4253737; rs4253770; rs4253777; rs2336904; rs4253711; rs4253754; rs4253798; rs4253748; rs4253727; rs4253723; rs4253710; rs4253714; rs6008160; rs4253708; rs4253718; rs4253774; rs4253722; rs4253767; rs4253732; rs5766741; rs4253726; rs4253799; rs5767700; rs7364297; rs4253736; rs4253794; rs4253752; rs4253731; rs4253766; rs4253721; rs4253717; rs4253742; rs4253744; rs4253697; rs4253771; rs4253746; rs4253725; rs4253739; rs4253720; rs4253738; rs4253755; rs1800245; rs4253795; rs4253716; rs4253735; rs4253734; rs5766743; rs4253779; rs4253741; rs4253753; rs6007662; rs4253768; rs4253743; rs4253745; rs4253772; rs4253763; rs4253724; rs4253759; rs4253733; rs4253715; rs8139794; rs4253740; rs4253749; rs8139663; rs41397552; rs11090791; rs11702902; rs11090817; rs6008123; rs7291727; rs5769175; rs5767636; rs9615238; rs5767560; rs5766734; rs6008126; rs5767633; rs11090818; rs8140236; rs12170204; rs9626730; rs11705483; rs11913971; rs7292459; rs5767634; rs4823477; rs6413511; rs1800243; rs1800242; rs9615759; rs1042311; rs5767686; rs1800236; rs12167302; rs9615163; rs41418950; rs34666721; rs5769287; rs35328780; rs7292112; rs11383159; rs7364140; rs5769365; rs34148860; rs5845740; rs35404482; rs35249750; rs41403648; rs35988564; rs6009112; rs5845739; rs36096470; rs41532849; rs881740; rs9615524; rs7286871; rs12484245; rs13053358; rs11538240; rs35966870; rs34896841; rs35838035; rs10643430; rs13053293; rs5767779; rs12171095; rs41479847; rs28772875; rs6009058; rs4592961; rs9627007; rs34109484; rs12159525; rs12170381; rs5845741; rs135544; rs41406451; rs35398060; rs28369325; rs5769129; rs12160049; rs34857047; rs12159225; rs6008042; rs7364165; rs10561065; rs7289761; rs5769184; rs9626764; rs12159821; rs5766682; rs41362646; rs41465647; rs3840962; rs5769088; rs41371446; rs2238833; rs4823487; rs9626756; rs7290774; rs41368348; rs5769276; rs34001104; rs35552991; rs28716636; rs13055301; rs5767424; rs12167354; rs1055658; rs41477146; rs5769364; rs36096495; rs5769356; rs35281820; rs35038216; rs41371949; rs5769142; rs11703765; rs35808855; rs6009014; rs41489145; rs9626751; rs135537; rs41355347; rs34437230; rs9615534; rs6007965; rs12159097; rs9615784; rs11344804; rs5769219; rs9615523; rs16994976; rs9626716; rs28895660; rs41329344; rs35345592; rs41489148; rs1800244; rs13054427; rs11912612; rs11703766; rs36124248; rs12166902; rs6008974; rs13055320; rs5769112; rs41332048; rs12169623; rs5769206; rs36074474; rs35436527; rs13056945; rs8139926; rs9627217; rs6008089; rs10570542; rs34977841; rs11325484; rs35637220; rs9615694; rs17847852; rs4365564; rs5767667; rs8135879; rs12166737; rs5767617; rs5766714; rs9626745; rs2336905; rs6008193; rs9615695; rs7290878; rs1973929; rs28875881; rs41526048; rs35528985; rs12168403; rs34108706; rs34716781; rs9626811; rs41461946; rs12168939; rs6008129; rs34902389; rs12166868; rs10563623; rs10427969; rs8141725; rs4365565; rs5767650; rs34142992; rs9627047; rs7290473; rs5767708; rs6008149; rs34052175; rs11703314; rs6008161; rs10593071; rs35418581; rs11445888; rs35658961; rs34873839; rs10658167; rs41497148; rs35027666; rs6008116; rs34774436; rs11270575; rs34036883; rs35700219; rs6008093; rs6007639; rs13057868; rs28669215; rs11332243; rs41343752; rs28508200; rs2283673; rs5767618; rs28786744; rs10591809; rs12170430; rs12168830; rs12167549; rs34858419; rs13058348; rs8141442; rs6008191; rs6008096; rs5767763; rs35145000; rs28584795; rs6007673; rs7286742; rs12168937; rs28828403; rs35615646; rs34406573; rs13058552; rs6008130; rs12166556; rs13056831; rs9626742; rs34363509; rs9615487; rs5767320; rs34775146; rs9626709; rs12157295; rs10154668; rs1053332; rs11705226; rs12106599; rs12159251; rs135556; rs135557; rs135559; rs135560; rs135561; rs135562; rs14842; rs14843; rs16995065; rs16995067; rs16995069; rs5767842; rs6008923; rs717926; rs7284616; rs7289611; rs7291028; rs9626816; rs9626823; rs9627278; rs9627280; rs9627281; rs9627287

# Macromolecular_Interacting_Partner_4_General_References:
7684926; 7981125; 8993548; 10591208; 9238002; 10681503

# Macromolecular_Interacting_Partner_4_References:
12135937

# Macromolecular_Interacting_Partner_5_ID:
8317

# Macromolecular_Interacting_Partner_5_Name:
Solute carrier family 22

# Macromolecular_Interacting_Partner_5_Synonyms:
Organic cation transporter, member 16

# Macromolecular_Interacting_Partner_5_Gene_Name:
SLC22A16

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Solute carrier family 22
MGSRHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQ
VVFHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSK
KEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLG
RRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRT
WASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGR
YEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTL
TVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAY
SLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGS
GSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAA
KLESENESKSSKLLLTTNNSGLEKTEAITPRDSGLGE

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
577

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
64615

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
8.23

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_5_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF07690:MFS_1

# Macromolecular_Interacting_Partner_5_Signals:
1-35

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
154-176; 183-203; 213-235; 242-264; 274-296; 359-378; 388-410; 417-436; 441-463; 468-490; 500-522

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
28837286

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
Q86VW1_HUMAN (Q86VW1)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
SLC22A16

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
SLC22A16

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:20302

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1734 bp
ATGGGGTCCCGCCACTTCGAGGGGATTTATGACCACGTGGGGCACTTCGGCAGATTCCAG
AGAGTCCTCTATTTCATATGTGCCTTCCAGAACATCTCTTGTGGTATTCACTACTTGGCT
TCTGTGTTCATGGGAGTCACCCCTCATCATGTCTGCAGGCCCCCAGGCAATGTGAGTCAG
GTTGTTTTCCATAATCACTCTAATTGGAGTTTGGAGGACACCGGGGCCCTGTTGTCTTCA
GGCCAGAAAGATTATGTTACGGTGCAGTTGCAGAATGGTGAGATCTGGGAGCTCTCAAGG
TGTAGCAGGAATAAGAGGGAGAACACATCGAGTTTGGGCTATGAATACACTGGCAGTAAG
AAAGAGTTTCCTTGTGTGGATGGCTACATATATGACCAGAACACATGGAAAAGCACTGCG
GTGACCCAGTGGAACCTGGTCTGTGACCGAAAATGGCTTGCAATGCTGATCCAGCCCCTA
TTTATGTTTGGAGTCCTACTGGGATCGGTGACTTTTGGCTACTTTTCTGACAGGCTAGGA
CGCCGGGTGGTCTTGTGGGCCACAAGCAGTAGCATGTTTTTGTTTGGAATAGCAGCGGCG
TTTGCAGTTGATTATTACACCTTCATGGCTGCTCGCTTTTTTCTTGCCATGGTTGCAAGT
GGCTATCTTGTGGTGGGGTTTGTCTATGTGATGGAATTCATTGGCATGAAGTCTCGGACA
TGGGCGTCTGTCCATTTGCATTCCTTTTTTGCAGTTGGAACCCTGCTGGTGGCTTTGACA
GGATACTTGGTCAGGACCTGGTGGCTTTACCAGATGATCCTCTCCACAGTGACTGTCCCC
TTTATCCTGTGCTGTTGGGTGCTCCCAGAGACACCTTTTTGGCTTCTCTCAGAGGGACGA
TATGAAGAAGCACAAAAAATAGTTGACATCATGGCCAAGTGGAACAGGGCAAGCTCCTGT
AAACTGTCAGAACTTTTATCACTGGACCTACAAGGTCCTGTTAGTAATAGCCCCACTGAA
GTTCAGAAGCACAACCTATCATATCTGTTTTATAACTGGAGCATTACGAAAAGGACACTT
ACCGTTTGGCTAATCTGGTTCACTGGAAGTTTGGGATTCTACTCGTTTTCCTTGAATTCT
GTTAACTTAGGAGGCAATGAATACTTAAACCTCTTCCTCCTGGGTGTAGTGGAAATTCCC
GCCTACACCTTCGTGTGCATCGCCATGGACAAGGTCGGGAGGAGAACAGTCCTGGCCTAC
TCTCTTTTCTGCAGTGCACTGGCCTGTGGTGTCGTTATGGTGATCCCCCAGAAACATTAT
ATTTTGGGTGTGGTGACAGCTATGGTTGGAAAATTTGCCATCGGGGCAGCATTTGGCCTC
ATTTATCTTTATACAGCTGAGCTGTATCCAACCATTGTAAGATCGCTGGCTGTGGGAAGC
GGCAGCATGGTGTGTCGCCTGGCCAGCATCCTGGCGCCGTTCTCTGTGGACCTCAGCAGC
ATTTGGATCTTCATACCACAGTTGTTTGTTGGGACTATGGCCCTCCTGAGTGGAGTGTTA
ACACTAAAGCTTCCAGAAACCCTTGGGAAACGGCTAGCAACTACTTGGGAGGAGGCTGCA
AAACTGGAGTCAGAGAATGAAAGCAAGTCAAGCAAATTACTTCTCACAACTAATAATAGT
GGGCTGGAAAAAACGGAAGCGATTACCCCCAGGGATTCTGGTCTTGGTGAATAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
BC047565

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_5_Locus:
6q22.1|6q21-q22.1

# Macromolecular_Interacting_Partner_5_SNPs:
Not Available

# Macromolecular_Interacting_Partner_5_General_References:
12477932

# Macromolecular_Interacting_Partner_5_References:
16195500

# Macromolecular_Interacting_Partner_6_ID:
8300

# Macromolecular_Interacting_Partner_6_Name:
Mitochondrial carnitine/acylcarnitine carrier protein

# Macromolecular_Interacting_Partner_6_Synonyms:
Carnitine/acylcarnitine translocase; CAC; Solute carrier family 25 member 20

# Macromolecular_Interacting_Partner_6_Gene_Name:
SLC25A20

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Mitochondrial carnitine/acylcarnitine carrier protein
MADQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFR
KTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLS
GVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDV
PASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTA
PPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFLNWATPN
L

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
301

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
32944

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
9.84

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  binding
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  organelle membrane
Component:  organelle inner membrane
Component:  mitochondrial inner membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00153:Mito_carr

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
13-31
74-93
113-131
171-190
212-230
268-287

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
2765075

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
MCAT_HUMAN (O43772)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SLC25A20

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SLC25A20

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:1421

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>906 bp
ATGGCCGACCAGCCAAAACCCATCAGCCCGCTCAAGAACCTGCTGGCCGGCGGCTTTGGC
GGCGTGTGCCTGGTGTTCGTCGGTCACCCTCTGGACACGGTCAAGGTCCGACTGCAGACA
CAGCCACCGAGTTTGCCTGGACAACCTCCCATGTACTCTGGGACCTTTGACTGTTTCCGG
AAGACTCTTTTTAGAGAGGGCATCACGGGGCTATATCGGGGAATGGCTGCCCCTATCATC
GGGGTCACTCCCATGTTTGCCGTGTGCTTCTTTGGGTTTGGTTTGGGGAAGAAACTACAA
CAGAAACACCCAGAAGATGTGCTCAGCTATCCCCAGCTTTTTGCAGCTGGGATGTTATCT
GGCGTATTCACCACAGGAATCATGACTCCTGGAGAACGGATCAAGTGCTTATTACAGATT
CAGGCTTCTTCAGGAGAAAGCAAGTACACTGGTACCTTGGACTGTGCAAAGAAGCTGTAC
CAGGAGTTTGGGATCCGAGGCATCTACAAAGGGACTGTGCTTACCCTTATGCGAGATGTC
CCAGCTAGTGGAATGTATTTCATGACATATGAATGGCTGAAAAATATCTTCACTCCGGAG
GGAAAGAGGGTCAGTGAGCTCAGTGCCCCTCGGATCTTGGTGGCTGGGGGCATTGCAGGG
ATCTTCAACTGGGCTGTGGCAATCCCCCCAGATGTGCTCAAGTCTCGATTCCAGACTGCA
CCTCCTGGGAAATATCCTAATGGTTTCAGAGATGTGCTGAGGGAGCTGATCCGGGATGAA
GGAGTCACATCCTTGTACAAAGGGTTCAATGCAGTGATGATCCGAGCCTTCCCAGCCAAT
GCGGCCTGTTTCCTTGGCTTTGAAGTTGCCATGAAGTTCCTTAATTGGGCCACCCCCAAC
TTGTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
Y10319

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_6_Locus:
3p21.31

# Macromolecular_Interacting_Partner_6_SNPs:
rs4974087; rs7623023; rs4974079; rs6446253; rs6446252; rs7649458; rs7639332; rs4974085; rs7431710; rs13079908; rs7428387; rs7431857; rs4974088; rs7611358; rs7621226; rs6795701; rs6414612; rs13318132; rs9754878; rs12493289; rs11920534; rs11924597; rs9840684; rs11708022; rs35989076; rs14828; rs13080008; rs34596408; rs34510184; rs13060124; rs35652226; rs13073997; rs28503592; rs34365904; rs35547809; rs11293883; rs35205947; rs9882714; rs35086428; rs7433475; rs10662156; rs11425264; rs35871910; rs35804097; rs10582743; rs10632627; rs7430833; rs34135844; rs11390016; rs28642807; rs35306259; rs11714489; rs10718030; rs28839306; rs11353457; rs11447684; rs12054069; rs35575058; rs35720561; rs13086655; rs28561609; rs35149348; rs7430816; rs34139351; rs34131216; rs13079676; rs36073609; rs34738043; rs10049072; rs11718723; rs12054249; rs34153109; rs4974086; rs34396187; rs11316117; rs35422032; rs34446507; rs34608920; rs7426635; rs35409520; rs36104878; rs9755751; rs13061999; rs35874881; rs34856730; rs34600060; rs34340055; rs10780033; rs12715430; rs13090141; rs7430501

# Macromolecular_Interacting_Partner_6_General_References:
9399886; 9837782; 12859414

# Macromolecular_Interacting_Partner_6_References:
12093282; 12882971; 15757911; 16602102

# Macromolecular_Interacting_Partner_7_ID:
8305

# Macromolecular_Interacting_Partner_7_Name:
Erythropoietin precursor

# Macromolecular_Interacting_Partner_7_Synonyms:
Epoetin

# Macromolecular_Interacting_Partner_7_Gene_Name:
EPO

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Erythropoietin precursor
MGVHECPAWLWLLLSLLSLPLGLPVLGAPPRLICDSRVLERYLLEAKEAENITTGCAEHC
SLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQL
HVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKL
KLYTGEACRTGDR

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
193

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
21307

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
8.21

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  cytokine activity
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  erythropoietin receptor binding
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00758:EPO_TPO

# Macromolecular_Interacting_Partner_7_Signals:
1-27

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
312304

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
EPO_HUMAN (P01588)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
EPO

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
EPO

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:3415

# Macromolecular_Interacting_Partner_7_PDB_ID:
1BUY

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>582 bp
ATGGGGGTGCACGAATGTCCTGCCTGGCTGTGGCTTCTCCTGTCCCTGCTGTCGCTCCCT
CTGGGCCTCCCAGTCCTGGGCGCCCCACCACGCCTCATCTGTGACAGCCGAGTCCTGCAG
AGGTACCTCTTGGAGGCCAAGGAGGCCGAGAATATCACGACGGGCTGTGCTGAACACTGC
AGCTTGAATGAGAATATCACTGTCCCAGACACCAAAGTTAATTTCTATGCCTGGAAGAGG
ATGGAGGTCGGGCAGCAGGCCGTAGAAGTCTGGCAGGGCCTGGCCCTGCTGTCGGAAGCT
GTCCTGCGGGGCCAGGCCCTGTTGGTCAACTCTTCCCAGCCGTGGGAGCCCCTGCAGCTG
CATGTGGATAAAGCCGTCAGTGGCCTTCGCAGCCTCACCACTCTGCTTCGGGCTCTGGGA
GCCCAGAAGGAAGCCATCTCCCCTCCAGATGCGGCCTCAGCTGCTCCACTCCGAACAATC
ACTGCTGACACTTTCCGCAAACTCTTCCGAGTCTACTCCAATTTCCTCCGGGGAAAGCTG
AAGCTGTACACAGGGGAGGCCTGCAGGACAGGGGACAGATGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
X02158

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_7_Locus:
7q22

# Macromolecular_Interacting_Partner_7_SNPs:
rs11976235; rs507392; rs551238; rs1617640; rs4729606; rs576236; rs1126887; rs34144627; rs564449; rs7789679; rs10550542; rs35495521; rs34371939; rs6977067; rs10249669; rs10263391; rs34937405; rs1647644; rs1734907; rs4548109; rs4729607; rs504141; rs506597; rs534043

# Macromolecular_Interacting_Partner_7_General_References:
3838366; 3865178; 9799793; 12853948; 8396923; 3949763; 6698989; 3346214; 3219367; 1820196; 9774108

# Macromolecular_Interacting_Partner_7_References:
12094827; 12602467; 12751050; 16412827

# Macromolecular_Interacting_Partner_8_ID:
8202

# Macromolecular_Interacting_Partner_8_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_8_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_8_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_8_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_8_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_8_Signals:
None

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_8_Locus:
10q22

# Macromolecular_Interacting_Partner_8_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_8_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_8_References:
12388290; 15212755

# Macromolecular_Interacting_Partner_9_ID:
8458

# Macromolecular_Interacting_Partner_9_Name:
Carnitine O-palmitoyltransferase I, muscle isoform

# Macromolecular_Interacting_Partner_9_Synonyms:
CPT I; CPTI-M; Carnitine palmitoyltransferase 1B; Carnitine palmitoyltransferase I-like protein

# Macromolecular_Interacting_Partner_9_Gene_Name:
CPT1B

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Carnitine Opalmitoyltransferase I, muscle isoform
MAEAHQAVAFQFTVTPDGVDFRLSREALKHVYLSGINSWKKRLIRIKNGILRGVYPGSPT
SWLVVIMATVGSSFCNVDISLGLVSCIQRCLPQGCGPYQTPQTRALLSMAIFSTGVWVTG
IFFFRQTLKLLLCYHGWMFEMHGKTSNLTRIWAMCIRLLSSRHPMLYSFQTSLPKLPVPR
VSATIQRYLESVRPLLDDEEYYRMELLAKEFQDKTAPRLQKYLVLKSWWASNYVSDWWEE
YIYLRGRSPLMVNSNYYVMDLVLIKNTDVQAARLGNIIHAMIMYRRKLDREEIKPVMALG
IVPMCSYQMERMFNTTRIPGKDTDVLQHLSDSRHVAVYHKGRFFKLWLYEGARLLKPQDL
EMQFQRILDDPSPPQPGEEKLAALTAGGRVEWAQARQAFFSSGKNKAALEAIERAAFFVA
LDEESYSYDPEDEASLSLYGKALLHGNCYNRWFDKSFTLISFKNGQLGLNAEHAWADAPI
IGHLWEFVLGTDSFHLGYTETGHCLGKPNPALAPPTRLQWDIPKQCQAVIESSYQVAKAL
ADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDRGKFCLTYEASMTRMFREG
RTETVRSCTSESTAFVQAMMEGSHTKADLRDLFQKAAKKHQNMYRLAMTGAGIDRHLFCL
YLVSKYLGVSSPFLAEVLSEPWRLSTSQIPQSQIRMFDPEQHPNHLGAGGGFGPVADDGY
GVSYMIAGENTIFFHISSKFSSSETNAQRFGNHIRKALLDIADLFQVPKAYS

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
772

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
87802

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
8.77

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Palmitoyl-CoA + L-carnitine = CoA + L- palmitoylcarnitine

# Macromolecular_Interacting_Partner_9_Pathway:
map00071  Fatty acid metabolism

# Macromolecular_Interacting_Partner_9_Reaction:
palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00755:Carn_acyltransf

# Macromolecular_Interacting_Partner_9_Signals:
None

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
48-73
103-122

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
EC 2.3.1.21

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
1621202

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
CPT1B_HUMAN (Q92523)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
CPT1B

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
CPT1B

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:2329

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>2319 bp
ATGGCGGAAGCTCACCAGGCCGTGGCCTTCCAGTTCACGGTGACCCCAGACGGGGTCGAC
TTCCGGCTCAGTCGGGAGGCCCTGAAACACGTCTACCTGTCTGGGATCAACTCCTGGAAG
AAACGCCTGATCCGCATCAAGAATGGCATCCTCAGGGGCGTGTACCCTGGCAGCCCCACC
AGCTGGCTGGTCGTCATCATGGCAACAGTGGGTTCCTCCTTCTGCAACGTGGACATCTCC
TTGGGGCTGGTCAGTTGCATCCAGAGATGCCTCCCTCAGGGGTGTGGCCCCTACCAGACC
CCGCAGACCCGGGCACTTCTCAGCATGGCCATCTTCTCCACGGGCGTCTGGGTGACGGGC
ATCTTCTTCTTCCGCCAAACCCTGAAGCTGCTTCTCTGCTACCATGGGTGGATGTTTGAG
ATGCATGGCAAGACCAGCAACTTGACCAGGATCTGGGCTATGTGTATCCGCCTTCTATCC
AGCCGGCACCCTATGCTCTACAGCTTCCAGACATCTCTGCCCAAGCTTCCTGTGCCCAGG
GTGTCAGCCACAATTCAGCGGTACCTAGAGTCTGTGCGCCCCTTGTTGGATGATGAGGAA
TATTACCGCATGGAGTTGCTGGCCAAAGAATTCCAGGACAAGACTGCCCCCAGGCTGCAG
AAATACCTGGTGCTCAAGTCATGGTGGGCAAGTAACTATGTGAGTGACTGGTGGGAAGAG
TACATCTACCTTCGAGGCAGGAGCCCTCTCATGGTGAACAGCAACTATTATGTCATGGAC
CTTGTGCTCATCAAGAATACAGACGTGCAGGCAGCCCGCCTGGGAAACATCATCCACGCC
ATGATCATGTATCGCCGTAAACTGGACCGTGAAGAAATCAAGCCTGTGATGGCACTGGGC
ATAGTGCCTATGTGCTCCTACCAGATGGAGAGGATGTTCAACACCACTCGGATCCCGGGC
AAGGACACAGATGTGCTACAGCACCTCTCAGACAGCCGGCACGTGGCTGTCTACCACAAG
GGACGCTTCTTCAAGCTGTGGCTCTATGAGGGCGCCCGTCTGCTCAAGCCTCAGGATCTG
GAGATGCAGTTCCAGAGGATCCTGGACGACCCCTCCCCACCTCAGCCTGGGGAGGAGAAG
CTGGCAGCCCTCACTGCAGGAGGAAGGGTGGAGTGGGCGCAGGCACGCCAGGCCTTCTTT
AGCTCTGGAAAGAATAAGGCTGCCTTGGAGGCCATCGAGCGTGCCGCTTTCTTCGTGGCC
CTGGATGAGGAATCCTACTCCTATGACCCCGAAGATGAGGCCAGCCTCAGCCTCTATGGC
AAGGCCCTGCTACATGGCAACTGCTACAACAGGTGGTTTGACAAATCCTTCACTCTCATT
TCCTTCAAGAATGGCCAGTTGGGTCTCAATGCAGAGCATGCGTGGGCAGATGCTCCCATC
ATTGGGCACCTCTGGGAGTTTGTCCTGGGCACAGACAGCTTCCACCTGGGCTACACGGAG
ACCGGGCACTGCCTGGGCAAACCGAACCCTGCGCTCGCACCTCCTACACGGCTGCAGTGG
GACATTCCAAAACAGTGCCAGGCGGTCATCGAGAGTTCCTACCAGGTGGCCAAGGCGTTG
GCAGACGACGTGGAGTTGTACTGCTTCCAGTTCCTGCCCTTTGGCAAAGGCCTCATCAAG
AAGTGCCGGACCAGCCCTGATGCCTTTGTGCAGATCGCGCTGCAGCTGGCTCACTTCCGG
GACAGGGGTAAGTTCTGCCTGACCTATGAGGCCTCAATGACCAGAATGTTCCGGGAGGGA
CGGACTGAGACTGTGCGTTCCTGTACCAGCGAGTCCACAGCCTTTGTGCAGGCCATGATG
GAGGGGTCCCACACAAAAGCAGACCTGCGAGATCTCTTCCAGAAGGCTGCTAAGAAGCAC
CAGAATATGTACCGCCTGGCCATGACCGGGGCAGGGATCGACAGGCACCTCTTCTGCCTT
TACTTGGTCTCCAAGTACCTAGGAGTCAGCTCTCCTTTCCTTGCTGAGGTGCTCTCGGAA
CCCTGGCGTCTCTCCACCAGCCAGATCCCCCAATCCCAGATCCGCATGTTCGACCCAGAG
CAGCACCCCAATCACCTGGGCGCTGGAGGTGGCTTTGGCCCTGTAGCAGATGATGGCTAT
GGAGTTTCCTACATGATTGCAGGCGAGAACACGATCTTCTTCCACATCTCCAGCAAGTTC
TCAAGCTCAGAGACGAACGCCCAGCGCTTTGGAAACCACATCCGCAAAGCCCTGCTGGAC
ATTGCTGATCTTTTCCAAGTTCCCAAGGCCTACAGCTGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
D87812

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_9_Locus:
22q13.33

# Macromolecular_Interacting_Partner_9_SNPs:
rs5770904; rs2334104; rs1804702; rs1803460; rs41309651; rs131762; rs9616791; rs28376893; rs9616868; rs11912747; rs28505118; rs9628214; rs1056964; rs1056971; rs1135081; rs11705579; rs11912521; rs12160714; rs12165562; rs12167151; rs12288; rs12330127; rs12627787; rs131745; rs131746; rs131747; rs131748; rs131749; rs131750; rs131756; rs131757; rs131758; rs131759; rs131760; rs131761; rs131766; rs131768; rs140514; rs140515; rs140516; rs140517; rs140518; rs15195; rs1557502; rs1557503; rs17001616; rs17836732; rs2073604; rs2073605; rs2269381; rs2269382; rs2269383; rs2269386; rs2269387; rs2516557; rs3213445; rs3213446; rs34744246; rs35464294; rs3752393; rs3752396; rs3810647; rs470117; rs4824130; rs5770911; rs5770913; rs5770916; rs5770917; rs6009931; rs6009932; rs6010007; rs6010012; rs6010014; rs6520156; rs7238; rs7287960; rs762676; rs762677; rs8137073; rs8137301; rs8137478; rs8141883; rs8142477; rs8142621; rs86337; rs877294; rs963980

# Macromolecular_Interacting_Partner_9_General_References:
8679700; 9344464; 9070950; 9199240; 9224698; 11258795; 10591208

# Macromolecular_Interacting_Partner_9_References:
11866664; 12079850; 12392496; 14667938

# Macromolecular_Interacting_Partner_10_ID:
8043

# Macromolecular_Interacting_Partner_10_Name:
Putative UST1-like organic anion transporter

# Macromolecular_Interacting_Partner_10_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_10_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Putative UST1like organic anion transporter
MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP
DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW
VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY
LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA
ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR
KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS
TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL
LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG
ALASLVMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENEGVNSLAA
PQRSSVL

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
547

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
60977

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
7.61

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_10_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_10_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF07690:MFS_1

# Macromolecular_Interacting_Partner_10_Signals:
1-33

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
178-200; 204-226; 233-255; 260-279; 350-368; 378-400; 407-426; 430-449; 470-492; 496-515

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
40287955

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
Q6T423_HUMAN (Q6T423)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_10_hgnc_id:
Not Available

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>1644 bp
ATGGCCTTTCAGGACCTCCTAGATCAAGTTGGAGGCCTGGGGAGATTCCAGATCCTTCAG
ATGGTTTTCCTTATAATGTTCAACGTCATAGTATACCATCAAACTCAGCTGGAGAACTTC
GCAGCATTCATACTTGATCATCGCTGCTGGGTTCATATACTGGACAATGACACTATCCCT
GACAATGACCCTGGGACCCTCAGCCAGGATGCCCTCCTGAGAATCTCCATCCCATTCGAC
TCAAATCTGAGGCCAGAGAAGTGTCGTCGCTTTGTCCATCCCCAGTGGAAGCTCATTCAT
CTGAATGGGACCTTCCCCAACACGAGTGAGCCAGATACAGAGCCCTGTGTGGATGGCTGG
GTATATGACCAAAGCTCCTTCCCTTCCACCATTGTGACTAAGTGGGATCTGGTATGCGAA
TCTCAACCACTGAATTCAGTAGCTAAATTTCTATTCATGGCTGGAATGATGGTGGGAGGC
AACCTATATGGCCATTTGTCAGACAGGTTTGGGAGAAAGTTCGTGCTCAGATGGTCTTAC
CTCCAGCTCGCCATTGTAGGCACCTGTGCGGCCTTTGCTCCCACCATCCTCGTATACTGC
TCCCTGCGCTTCTTGGCTGGGGCTGCTACATTTAGCATCATTGTAAATACTGTTTTGTTA
ATTGTAGAGTGGATAACTCACCAATTCTGTGCCATGGCATTGACATTGACACTTTGTGCT
GCTAGTATTGGACATATAACCCTGGGAAGCCTGGCTTTTGTCATTCGAGACCAGTGCATC
CTCCAGTTGGTGATGTCTGCACCATGCTTTGTCTTCTTTCTGTTCTCAAGGTGGCTGGCA
GAGTCTGCTCGGTGGCTCATTATCAACAACAAACCAGAAGAGGGCTTAAAGGAACTTAGA
AAAGCTGCACACAGGAATGGAATGAAGAATGCTGAAGACATCCTAACCATGGAGGTTTTG
AAATCCACCATGAAGCAAGAACTGGAGGCAGCACAGAAAAAGCATTCTCTTTGTGAATTG
CTCCGCATACCCAACATATGTAAAAGAATCTGTTTCCTGTCCTTTGTGAGATTTGCAAGT
ACCATCCCTTTTTGGGGCCTTACTTTGCACCTCCAGCATCTGGGAAACAATGTTTTCCTG
TTGCAGACTCTCTTTGGTGCAGTCACCCTCCTGGCCAATTGTGTTGCACCTTGGGCACTG
AATCACATGAGCCGTCGACTAAGCCAGATGCTTCTCATGTTCCTACTGGCAACCTGCCTT
CTGGCCATCATATTTGTGCCTCAAGAAATGCAGACCCTGCGTGTGGTTTTGGCAACCCTG
GGTGTGGGAGCTGCTTCTCTTGGCATTACCTGTTCTACTGCCCAAGAAAATGAACTAATT
CCTTCCATAATCAGGGGAAGAGCTACTGGAATCACTGGAAACTTTGCTAATATTGGGGGA
GCCCTGGCTTCCCTCGTGATGATCCTAAGCATATATTCTCGACCCCTGCCCTGGATCATC
TATGGAGTCTTTGCCATCCTCTCTGGCCTTGTTGTCCTCCTCCTTCCTGAAACCAGGAAC
CAGCCTCTTCTTGACAGCATCCAGGATGTGGAAAATGAGGGAGTAAATAGCCTAGCTGCC
CCTCAGAGGAGCTCTGTGCTATAG

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
AY437532

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_10_Locus:
Not Available

# Macromolecular_Interacting_Partner_10_SNPs:
Not Available

# Macromolecular_Interacting_Partner_10_General_References:
Not Available

# Macromolecular_Interacting_Partner_10_References:
12644265; 12802501; 14665638; 15238359

# Macromolecular_Interacting_Partner_11_ID:
7933

# Macromolecular_Interacting_Partner_11_Name:
Organic cation/carnitine transporter 1

# Macromolecular_Interacting_Partner_11_Synonyms:
Solute carrier family 22 member 4; Ergothioneine transporter; ET transporter

# Macromolecular_Interacting_Partner_11_Gene_Name:
SLC22A4

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Organic cation/carnitine transporter 1
MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSS
AWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS
QDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQ
TGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFA
VGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKA
AKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALS
LDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPV
DYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVY
LGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRDSMET
EENPKVLITAF

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
551

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
62156

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
7.27

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  ion transporter activity
Function:  transporter activity
 ||
>>>
Process:  ion transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_11_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_11_Specific_Function:
Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET)

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF07690:MFS_1

# Macromolecular_Interacting_Partner_11_Signals:
None

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
21-41
142-162
172-192
198-218
233-253
258-278
338-358
372-392
400-420
427-447
461-481
487-507

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
2605501

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
S22A4_HUMAN (Q9H015)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
SLC22A4

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
SLC22A4

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:10968

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>1656 bp
ATGCGGGACTACGACGAGGTGATCGCCTTCCTGGGCGAGTGGGGGCCCTTCCAGCGCCTC
ATCTTCTTCCTGCTCAGCGCCAGCATCATCCCCAATGGCTTCAATGGTATGTCAGTCGTG
TTCCTGGCGGGGACCCCGGAGCACCGCTGTCGAGTGCCGGACGCCGCGAACCTGAGCAGC
GCCTGGCGCAACAACAGTGTCCCGCTGCGGCTGCGGGACGGCCGCGAGGTGCCCCACAGC
TGCAGCCGCTACCGGCTCGCCACCATCGCCAACTTCTCGGCGCTCGGGCTGGAGCCGGGG
CGCGACGTGGACCTGGGGCAGCTGGAGCAGGAGAGCTGCCTGGATGGCTGGGAGTTCAGC
CAGGACGTCTACCTGTCCACCGTCGTGACCGAGTGGAATCTGGTGTGTGAGGACAACTGG
AAGGTGCCCCTCACCACCTCCCTGTTCTTCGTAGGCGTGCTCCTCGGCTCCTTCGTGTCC
GGGCAGCTGTCAGACAGGTTTGGCAGGAAGAACGTTCTCTTCGCAACCATGGCTGTACAG
ACTGGCTTCAGCTTCCTGCAGATTTTCTCCATCAGCTGGGAGATGTTCACTGTGTTATTT
GTCATCGTGGGCATGGGCCAGATCTCCAACTATGTGGTAGCCTTCATACTAGGAACAGAA
ATTCTTGGCAAGTCAGTTCGTATTATATTCTCTACATTAGGAGTGTGCACATTTTTTGCA
GTTGGCTATATGCTGCTGCCACTGTTTGCTTACTTCATCAGAGACTGGCGGATGCTGCTG
CTGGCGCTGACGGTGCCGGGAGTGCTGTGTGTCCCGCTGTGGTGGTTCATTCCTGAATCT
CCCCGATGGCTGATATCCCAGAGAAGATTTAGAGAGGCTGAAGATATCATCCAAAAAGCT
GCAAAAATGAACAACACAGCTGTACCAGCAGTGATATTTGATTCTGTGGAGGAGCTAAAT
CCCCTGAAGCAGCAGAAAGCTTTCATTCTGGACCTGTTCAGGACTCGGAATATTGCCATA
ATGACCATTATGTCTTTGCTGCTATGGATGCTGACCTCAGTGGGTTACTTTGCTCTGTCT
CTGGATGCTCCTAATTTACATGGAGATGCCTACCTGAACTGTTTCCTCTCTGCCTTGATT
GAAATTCCAGCTTACATTACAGCCTGGCTGCTATTGCGAACGCTGCCCAGGCGTTATATC
ATAGCTGCAGTACTGTTCTGGGGAGGAGGTGTGCTTCTCTTCATTCAACTGGTACCTGTG
GATTATTACTTCTTATCCATTGGTCTGGTCATGCTGGGAAAATTTGGGATCACCTCTGCT
TTCTCCATGCTGTATGTCTTCACTGCTGAGCTCTACCCAACCCTGGTCAGGAACATGGCG
GTGGGGGTCACATCCACGGCCTCCAGAGTGGGCAGCATCATTGCCCCCTACTTTGTTTAC
CTCGGTGCTTACAACAGAATGCTGCCCTACATCGTCATGGGTAGTCTGACTGTCCTGATT
GGAATCTTCACCCTTTTTTTCCCTGAAAGTTTGGGAATGACTCTTCCAGAAACCTTAGAG
CAGATGCAGAAAGTGAAATGGTTCAGATCTGGGAAAAAAACAAGAGACTCAATGGAGACA
GAAGAAAATCCCAAGGTTCTAATAACTGCATTCTGA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
AB007448

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_11_Locus:
5q31.1

# Macromolecular_Interacting_Partner_11_SNPs:
rs272893; rs1050152; rs272879; rs10479002; rs460415; rs270606; rs272842; rs273915; rs270602; rs270601; rs272884; rs272891; rs273914; rs273909; rs272874; rs156322; rs272883; rs156402; rs272873; rs272881; rs272878; rs270607; rs11568507; rs3792878; rs273913; rs272886; rs273912; rs270613; rs272889; rs3805669; rs270605; rs272872; rs272869; rs270612; rs3792885; rs3792884; rs3792877; rs3792881; rs11950562; rs273911; rs4705933; rs3792874; rs4551060; rs11739484; rs11242109; rs270614; rs17165928; rs3792892; rs3805671; rs7706762; rs270608; rs6860806; rs13179900; rs272882; rs273916; rs3805666; rs272894; rs13184379; rs272880; rs272875; rs272887; rs10075801; rs272870; rs3805678; rs4646196; rs461372; rs17689328; rs3805673; rs2304081; rs3792889; rs17165890; rs7706873; rs272888; rs2073839; rs272871; rs3805665; rs3805676; rs3828671; rs7723100; rs3792883; rs3805672; rs4646202; rs272885; rs3842601; rs272892; rs2073838; rs682821; rs3792882; rs3805668; rs270600; rs419291; rs3792880; rs3761659; rs10067074; rs3792875; rs3828672; rs4646194; rs3792879; rs9986224; rs270616; rs3792876; rs149218; rs404771; rs3828673; rs2306772; rs273917; rs3805667; rs9764895; rs456392; rs398064; rs4646201; rs17852518; rs455649; rs682843; rs35497612; rs3805664; rs34301845; rs192429; rs34271468; rs272877; rs34757387; rs34376246; rs187984; rs3991390; rs461268; rs4103615; rs34828166; rs461432; rs441700; rs35100978; rs3991389; rs270615; rs463039; rs41542912; rs13166503; rs36110281; rs441561; rs34441236; rs35463183; rs3991391; rs10570522; rs406912; rs617209; rs462469; rs434374; rs34381066; rs35371007; rs4646195; rs35799047; rs415531; rs34857419; rs35627981; rs3840352; rs383697; rs34382083; rs2569267; rs35042080; rs34604423; rs28626351; rs3840351; rs372267; rs381228; rs35329968; rs390964; rs467112; rs449917; rs461325; rs407688; rs13174072; rs448112; rs407951; rs35316456; rs428628; rs272890; rs35182825; rs189730; rs35015610; rs13175394; rs34969838; rs36043621; rs609083; rs187978; rs432941; rs34031485; rs13165834; rs190636; rs34245302; rs369469; rs10642143; rs453194; rs34021724; rs2569268; rs34450848; rs2569269; rs36128629; rs13180569; rs13156342; rs6881192; rs13165814; rs34889653; rs270603; rs34576295; rs149217; rs458378; rs34695718; rs465262; rs169257; rs272876; rs445000; rs35062503; rs2631358; rs36053960; rs34712803; rs34796927; rs444441; rs460959; rs35186843; rs378894; rs4646200; rs419366; rs620747; rs10631672; rs3914018; rs4646193; rs444293; rs35441678; rs403849; rs34644847; rs272838; rs607263; rs394284; rs34468004; rs35171916; rs34494670; rs4646197; rs33943647; rs448401; rs13165830; rs456497; rs34548304; rs34928075; rs10058074; rs11568498; rs11568501; rs11568502; rs11568503; rs11568504; rs11568506; rs11568508; rs11568510; rs12514583; rs156109; rs157572; rs162889; rs162890; rs162901; rs166587; rs1906083; rs2662314; rs272867; rs28532117; rs3761660; rs381870; rs410963; rs4371744; rs4646204; rs582849; rs679896; rs680124; rs6887830; rs7705189; rs9687291

# Macromolecular_Interacting_Partner_11_General_References:
9426230

# Macromolecular_Interacting_Partner_11_References:
14506273; 16135657; 16246312

# Macromolecular_Interacting_Partner_12_ID:
8591

# Macromolecular_Interacting_Partner_12_Name:
CROT protein

# Macromolecular_Interacting_Partner_12_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_12_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>CROT protein
MENQLAKSTEERTFQYQDSLPSLPVPSLEESLKKYLESVKPFANQEEYKKTEEIVQKFQS
GIGEKLHQKLLERAKGKRNWVFVVIIE

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
87

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
10214

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
7.53

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF00755:Carn_acyltransf

# Macromolecular_Interacting_Partner_12_Signals:
Not Available

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
Q86V17_HUMAN (Q86V17)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:2366

# Macromolecular_Interacting_Partner_12_PDB_ID:
1XMD

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
BC051874

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_12_Locus:
Not Available

# Macromolecular_Interacting_Partner_12_SNPs:
Not Available

# Macromolecular_Interacting_Partner_12_General_References:
12477932

# Macromolecular_Interacting_Partner_12_References:
Not Available

# Macromolecular_Interacting_Partner_13_ID:
8763

# Macromolecular_Interacting_Partner_13_Name:
Carnitine acyltransferase-like protein 1

# Macromolecular_Interacting_Partner_13_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_13_Gene_Name:
CATL1

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Carnitine acyltransferaselike protein 1
MAEAHQAVGFRPSLTSDGAEVELSAPVLQEIYLSGLRSWKRHLSRFWNDFLTGVFPASPL
SWLFLFSAIQLAWFLQLDPSLGLMEKIKELLPDWGGQHHGLRGVLAAALFASCLWGALIF
TLHVALRLLLSYHGWLLEPHGAMSSPTKTWLALVRIFSGRHPMLFSYQRSLPRQPVPSVQ
DTVRKYLESVRPILSDEDFDWTAVLAQEFLRLQASLLQWYLRLKSWWASNYVSDWWEEFV
YLRSRNPLMVNSNYYMMDFLYVTPTPLQAARAGNAVHALLLYRHRLNRQEIPPTLLMGMR
PLCSAQYEKIFNTTRIPGVQKDYIRHLHDSQHVAVFHRGRFFRMGTHSRNSLLSPRALEQ
QFQRILDDPSPACPHEEHLAALTAAPRGTWAQVRTSLKTQAAEALEAVEGAAFFVSLDAE
PAGLTREDPAASLDAYAHALLAGRGHDRWFDKSFTLIVFSNGKLGLSVEHSWADCPISGH
MWEFTLATECFQLGYSTDGHCKGHPDPTLPQPQRLQWDLPDQIHSSISLALRGAKILSEN
VDCHVVPFSLFGKSFIRRCHLSSDSFIQIALQLAHFRDRGQFCLTYESAMTRLFLEGRTE
TVRSCTREACNFVRAMEDKEKTDPQCLALFRVAVDKHQALLKAAMSGQGVDRHLFALYIV
SRFLHLQSPFLTQVHSEQWQLSTSQIPVQQMHLFDVHNYPDYVSSGGGFGPADDHGYGVS
YIFMGDGMITFHISSKKSSTKTDSHRLGQHIEDALLDVASLFQAGQHFKRRFRGSGKENS
RHRCGFLSRQTGASKASMTSTDF

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
803

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
90990

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
8.18

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF00755:Carn_acyltransf

# Macromolecular_Interacting_Partner_13_Signals:
1-74

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
53-75; 104-126

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
33340613

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
Q5K6N5_HUMAN (Q5K6N5)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
CATL1

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
CATL1

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:18540

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>2412 bp
ATGGCTGAAGCGCACCAGGCCGTGGGCTTCCGACCCTCGCTGACCTCGGACGGGGCTGAA
GTGGAACTCAGTGCCCCTGTGCTGCAGGAGATCTACCTCTCTGGCCTGCGCTCCTGGAAA
AGGCATCTCTCACGTTTCTGGAATGACTTTCTCACCGGTGTGTTTCCTGCCAGCCCCCTC
AGTTGGCTTTTCCTCTTCAGTGCCATCCAGCTTGCCTGGTTCCTCCAGCTGGATCCTTCC
TTAGGACTGATGGAGAAGATCAAAGAGTTGCTGCCTGACTGGGGTGGACAACACCACGGG
CTCCGGGGGGTCCTGGCAGCCGCGCTGTTTGCCTCGTGTTTGTGGGGAGCCCTGATCTTC
ACACTGCACGTGGCCCTGAGGCTGCTTCTGTCCTACCACGGCTGGCTTCTTGAGCCCCAC
GGAGCCATGTCCTCCCCCACCAAGACCTGGCTGGCCCTGGTCCGCATCTTCTCTGGCCGC
CACCCGATGCTGTTCAGTTACCAGCGCTCCCTGCCACGCCAGCCCGTGCCCTCTGTGCAG
GACACCGTGCGCAAGTACCTGGAGTCGGTCCGGCCCATCCTCTCCGACGAGGACTTCGAC
TGGACCGCGGTCCTGGCGCAGGAATTCCTGAGGCTGCAGGCGTCGCTGCTGCAGTGGTAC
CTGCGGCTCAAGTCCTGGTGGGCGTCCAATTATGTCAGTGACTGGTGGGAGGAATTTGTG
TACCTGCGCTCCCGAAATCCGCTGATGGTGAACAGCAACTATTACATGATGGACTTCCTG
TATGTCACACCCACGCCTCTGCAGGCAGCTCGCGCTGGGAATGCCGTCCATGCCCTCCTC
CTGTACCGCCACCGCCTGAACCGCCAGGAGATACCCCCGACTTTGCTGATGGGAATGCGC
CCCTTATGCTCTGCCCAGTACGAGAAGATCTTCAACACCACGCGGATTCCAGGGGTCCAA
AAAGACTACATCCGCCACCTCCATGACAGCCAACACGTGGCTGTCTTCCACCGGGGCCGA
TTCTTCCGCATGGGGACCCACTCCCGAAACAGCCTGCTTTCCCCGAGAGCCCTGGAGCAG
CAGTTTCAGAGAATCCTGGATGATCCCTCACCGGCCTGCCCCCACGAGGAACATCTGGCA
GCTCTGACAGCTGCTCCCAGGGGCACGTGGGCCCAGGTGCGGACATCCCTGAAGACCCAG
GCAGCGGAGGCCCTGGAGGCGGTGGAAGGGGCCGCTTTCTTTGTGTCACTGGATGCTGAG
CCCGCGGGGCTCACCAGGGAGGACCCGGCAGCGTCGTTGGATGCCTACGCCCATGCTCTG
CTGGCCGGCCGGGGCCATGATCGCTGGTTTGACAAATCCTTCACCCTAATCGTCTTCTCT
AACGGGAAGCTGGGCCTCAGCGTGGAGCACTCCTGGGCCGACTGCCCCATCTCAGGACAC
ATGTGGGAGTTCACTCTGGCTACAGAATGCTTTCAGCTGGGCTACTCAACAGACGGCCAC
TGCAAGGGGCACCCGGACCCCACACTACCCCAGCCCCAGCGGCTGCAATGGGACCTTCCA
GACCAGATCCACTCCTCCATCTCTCTAGCCCTGAGGGGAGCCAAGATCTTGTCTGAAAAT
GTCGACTGCCATGTCGTTCCATTCTCCCTATTTGGCAAGAGCTTCATCCGACGCTGCCAC
CTCTCTTCAGACAGCTTCATCCAGATCGCCTTGCAACTGGCCCACTTCCGGGACAGGGGT
CAATTCTGCCTGACTTATGAGTCGGCCATGACTCGCTTATTCCTGGAAGGCCGGACGGAG
ACGGTGCGGTCTTGCACGAGGGAGGCCTGCAACTTTGTCAGGGCCATGGAGGACAAAGAG
AAGACGGACCCACAGTGCCTCGCCCTGTTCCGCGTGGCAGTGGACAAGCACCAGGCTCTG
CTGAAGGCAGCCATGAGCGGGCAGGGAGTTGACCGCCACCTGTTTGCGCTGTACATCGTG
TCCCGATTCCTCCACCTGCAGTCGCCCTTCCTGACCCAGGTCCATTCGGAGCAGTGGCAG
CTGTCCACCAGCCAGATCCCTGTTCAGCAAATGCATCTGTTTGACGTCCACAATTACCCG
GACTATGTTTCCTCAGGCGGTGGATTCGGGCCTGCTGATGACCATGGTTATGGTGTTTCT
TATATCTTCATGGGGGATGGCATGATCACCTTCCACATCTCCAGCAAAAAATCAAGCACA
AAAACGGATTCCCACAGGCTGGGGCAGCACATTGAGGACGCACTGCTGGATGTGGCCTCC
CTGTTCCAGGCGGGACAGCATTTTAAGCGCCGGTTCAGAGGGTCAGGGAAGGAGAACTCC
AGGCACAGGTGTGGATTTCTCTCCCGCCAGACTGGGGCCTCCAAGGCCTCAATGACATCC
ACCGACTTCTGA

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
AF331918

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_13_Locus:
Not Available

# Macromolecular_Interacting_Partner_13_SNPs:
Not Available

# Macromolecular_Interacting_Partner_13_General_References:
Not Available

# Macromolecular_Interacting_Partner_13_References:
Not Available

End of HMDB00062

Beginning of HMDB00063
# Accession_No:
HMDB00063

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-24 10:27:39

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Cortisol

# Description:
Cortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.; As an oral or injectable drug, cortisol is also known as hydrocortisone. It is used as an immunosuppressive drug, given by injection in the treatment of severe allergic reactions such as anaphylaxis and angioedema, in place of prednisolone in patients who need steroid treatment but cannot take oral medication, and peri-operatively in patients on long-term steroid treatment to prevent an Addisonian crisis.; Cortisol or Hydrocortisone is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress.  It increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system.  Its synthetic counterpart (hydrocortisone) is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Cortisol is synthesized from pregnenolone. The amount of cortisol present in the serum undergoes diurnal variation, with the highest levels present in the early morning, and lower levels in the evening, several hours after the onset of sleep.; Cortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Synthetic cortisol, also known as hydrocortisone, is used as a drug mainly to fight allergies and inflammation; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Synthetic cortisol, also known as hydrocortisone, is used as a drug mainly to fight allergies and inflammation.

# Synonyms:
11-Hydrocortisone; 11-beta-Hydrocortisone; 11-beta-Hydroxycortisone; 11a-Hydroxycorticosterone; 11alpha-Hydroxycorticosterone; 11b,17,21-Trihydroxyprogesterone; 11b-Hydrocortisone; 11b-Hydroxycortisone; 11beta,17,21-Trihydroxyprogesterone; 11beta-Hydrocortisone; 11beta-Hydroxycortisone; 17-Hydroxycorticosterone; 17a-Hydroxycorticosterone; 17alpha-Hydroxycorticosterone; 4-Pregnene-11alpha,21-triol 3,20-dione; 4-Pregnene-11b,17a,21-triol-3,20-dione; Acticort; Aeroseb HC; Aeroseb-HC; Ala-Cort; Ala-Scalp; Alacort; Algicirtis; Amberin; Anflam; Anti-inflammatory hormone; Aquacort; Aquanil HC; Barseb HC; Basan-Corti; CaldeCORT Spray; Cetacort; Chronocort; Clear aid; Cleiton; Cobadex; Compound F; Cor-Tar-Quin; Cort-Dome; Cort-Quin; Cortanal; Cortenema; Cortesal; Corticreme; Cortifan; Cortifoam; Cortiment; Cortisol alcohol; Cortisolonum; Cortisporin; Cortisporin Otico; Cortispray; Cortizol; Cortolotion; Cortonema; Cortoxide;  Cremesone; Cremicort-H; Cutisol; Delacort; Derm-Aid; Dermil; Dermolate; Dihydrocostisone; Dioderm; Dome-cort; Domolene-HC; Drotic; Ef corlin; Efcorbin; Efcortelan; Efcortelin; Eldercort; Epicort; Epiderm H; Esiderm H; Evacort; Ficortril; Fiocortril; Foille Insetti; Genacort; Gyno-Cortisone; H-Cort; HC; Heb Cort; Heb-Cort; Hidalone; Hidro-Colisona; Hidrocortisona; Hycort; Hycortol; Hycortole; Hydracort; Hydrasson; Hydro-Adreson; Hydro-colisona; Hydrocort; Hydrocortal; Hydrocorticosterone; Hydrocortisone; Hydrocortisone alcohol; Hydrocortisone base; Hydrocortisone free alcohol; Hydrocortisonum; Hydrocortistab; Hydrocortisyl; Hydrocortone; Hydroskin; Hydroxycortisone; Hysone; Hytisone; Hytone; Hytone lotion; Idrocortisone; Incortin-H; Incortin-hydrogen; Kendall's compound F; Komed HC; Kyypakkaus; Lacticare HC; Lacticare-HC; Lactisona; Lubricort; Maintasone; Medicort; Meusicort; Mildison; Milliderm; Neo-Cort-Dome; Neosporin-H Ear; Nutracort; Nystaform-HC; Optef; Otalgine; Otic-Neo-Cort-Dome; Otobiotic; Otocort; Otosone-F; Pediotic Suspension; Penecort; Permicort; Polcort H; Preparation H Hydrocortisone Cream; Prepcort; Prestwick_265; Prevex HC; Proctocort; Proctofoam; Protocort; Racet; Rectoid; Reichstein's substance M; Remederm HC; Sanatison; Scalpicin Capilar; Schericur; Scheroson F; Sigmacort; Signef; Stiefcorcil; Synacort; Systral Hydrocort; Tarcortin; Timocort; Topicort; Transderma H; Traumaide; Uniderm; Vioform-Hydrocortisone; VoSol HC; Vytone; Zenoxone; alphaderm

# Chemical_IUPAC_Name:
11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

# Chemical_Formula:
C21H30O5

# Chemical_Structure:
tbl_chemical:::HMDB00063_ZOOM.png:::119283167617756999

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00063_THUMB.png:::119283167418930668

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Sterols; Steroids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
ketone; primary alcohol; alkene; secondary alcohol; tertiary alcohol

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
362.20932

# Molecular_Weight_Avg:
362.45990

# Smiles_String_isomeric:
C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@]2(O)C(=O)CO

# Smiles_String_canonical:
CC12CC(O)C3C(CCC4=CC(=O)CCC34C)C1CCC2(O)C(=O)CO

# KEGG_Compound_ID:
C00735

# BioCyc_ID:
CPD-286

# PubChem_CID:
5754

# PubChem_SID:
7847156; 7852206; 8153531; 4266384; 148533; 11404513; 8144588; 75748; 841765; 11466475; 10321360; 3154635; 7979545; 12173621; 855803; 11486169; 12013447; 3998; 11467595; 8138524

# OMIM_ID:
Not Available

# Metagene_ID:
3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY: 95; HYPOADRENOCORTICISM, FAMILIAL: 239; 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1): 458; ACTH DEFICIENCY, ISOLATED: 47; GLUCOCORTICOID RESISTANCE: 495; GLUCOCORTICOID DEFICIENCY, FAMILIAL ISOLATED. MIGEON SYNDROME: 46; 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17): 321; ADRENAL HYPOPLASIA. ADDISON DISEASE, X-LINKED: 45; 21-HYDROXYLASE DEFICIENCY (CYP21): 235

# BiGG_ID:
35828

# Wikipedia_ID:
Cortisol

# METLIN_ID:
5124

# Ref_ID:
2822298; 15257879; 16707164; 16320162; 12589391; 16140708; 16633890; 1620285; 16195034; 8884541; 16108840; 16023372; 11916927; 15172099; 2031862; 10525017; 9267318; 16002918; 15870835; 9612666

# ChEBI_ID:
17650

# CAS_Registry_Number:
50-23-7

# InChI:
InChI=1/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16?,18+,19-,20-,21+/m0/s1

# Synthesis_Reference:
Journal of the American Chemical Society  (1953),  75  5369-70.

# Melting_Point:
220 oC

# Melting_Point_predicted:
139.9 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.32 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
0.199 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
1.61 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
1.79 [Predicted by ALOGPS]; 0.5 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::1161386893.pdf:::224707512066432>>>tbl_chemical:::1161387053.html:::183218979923908

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::1161387054.mol:::169141193525550

# SDF_File_[Text]:
tbl_chemical:::HMDB00063.sdf:::119283166657694235

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00063.pdb:::119283167281165108

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::050105_P00_07_IS_1DP_presat.png:::11509185500719021

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::050105_P00_07_IS_1DP_presat.zip:::115091855014871298

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050105_P00_07_IS_2DHSQC_71.png:::119315951580475856

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050105_P00_07_IS_2DHSQC_71.zip:::119315951591165

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050105_P00_07_IS_2DHSQC_71_Assigned.png:::119315951614879257

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Cortisol.gif:::113273210445334042

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00063_peaks.txt:::1156309521445783217

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Cortisol_C.gif:::1132737672128803614

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00063_peaks.txt:::1156310711872663143

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00063L.png:::117555262363768555; Medium Energy:tbl_ms:::HMDB00063M.png:::117555267737593136; High Energy:tbl_ms:::HMDB00063H.png:::117555271352681322

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane; Cytoplasm; endoplasmic reticulum; mitochondria

# Tissue_Location:
Adipose Tissue; Adrenal Cortex; Adrenal Gland; Adrenal Medulla; Bladder; Brain; Fetus; Fibroblasts; Gonads; Gut; Intestine; Kidney; Liver; Lymphocyte; Muscle; Nerves; Neurons; Pancreas; Placenta; Platelet; Prostate; Skeletal Muscle; Skin; Spleen; Testes

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Urine	1.77 (1.28-2.27)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9267318
Blood	0.480(0.110-0.850)	umol/L	Adult:>18_yrs_old	Both	Normal	Wikipedia
Blood	0.199 (0.058-0.475)	umol/L	Infant:0-1_yr_old	Both	Normal	10525017
Blood	0.359 (0.130-0.519)	umol/L	Infant:0-1_yr_old	Both	Normal	10525017
Blood	0.427 (0.110-0.744)	umol/L	Infant:0-1_yr_old	Both	Normal	10525017
Blood	0.386 (0.100-0.671)	umol/L	Infant:0-1_yr_old	Both	Normal	10525017
Blood	0.348 (0.090-0.605)	umol/L	Infant:0-1_yr_old	Both	Normal	10525017
Blood	0.313 (0.081-0.545)	umol/L	Infant:0-1_yr_old	Both	Normal	10525017
Blood	0.282 (0.073-0.491)	umol/L	Infant:0-1_yr_old	Both	Normal	10525017
Blood	0.255 (0.066-0.443)	umol/L	Infant:0-1_yr_old	Both	Normal	10525017
Cerebrospinal_Fluid(CSF)	0.052 +/- 0.023	umol/L	Elderly:>65_yrs_old	N/A	Normal	12589391
Cerebrospinal_Fluid(CSF)	0.02 +/- 0.011 	umol/L	Adult:>18_yrs_old	Male	Normal	12589391
Saliva	2.35	umol/L	Adult:>18_yrs_old	Both	Normal	15257879


# Concentration_[Abnormal]:
Cerebrospinal_Fluid(CSF)	0.0096 (0.0027-0.016)	N/A	Adult:>18_yrs_old	Female	Benign gynecological diseases	10585175
Cerebrospinal_Fluid(CSF)	0.0001+/- 0.00001	uM	Adult:>18_yrs_old	Female	Functional Hypothalamic Amenorrhea (FHA) female	16464944
Cerebrospinal_Fluid(CSF)	0.03 +/- 0.005 	uM	Adult:>18_yrs_old	Male	Normal after treatment with Ketoconazole	12589391
Saliva	8.69	umol/L	Adult:>18_yrs_old	Both	Stress period	15257879


# Associated_Disorders:
17-alpha-hydroxylase Deficiency; 3-Beta-Hydroxysteroid Dehydrogenase Deficiency; ACTH Deficiency, Isolated; Addison's Disease; Adrenal Adenoma; Adrenal Hypoplasia; Adrenal Insufficiency; Benign gynecological diseases; Cushing's Syndrome; Functional Hypothalamic Amenorrhea (FHA) female; Glucocorticoid Deficiency, Familial Isolated; Hypoadrenocorticism, Familial; Migeon Syndrome; Normal after treatment with Ketoconazole; Stress period

# Pathway_Names:
C21-Steroid hormone metabolism;Androgen and estrogen metabolism

# Pathway_Images:
;

# KEGG_Images:
map00140;map00150

# Pathway_Graphs:
;

# Pathway_SBMLs:
;

# Metabolic_Enzyme_1_ID:
5683

# Metabolic_Enzyme_1_Name:
Cytochrome P450 11B1, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
CYPXIB1; P450C11; P-450c11; Steroid 11-beta-hydroxylase

# Metabolic_Enzyme_1_Gene_Name:
CYP11B1

# Metabolic_Enzyme_1_Protein_Sequence:
>Cytochrome P450 11B1, mitochondrial precursor
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPQRPGNRWLRLLQIWREQG
YEDLHLEVHQ
TFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAY
RQHRGHKCGVFLLNGPEWRFN
RLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQ
NARGSLTLDVQPSIFHYTIEASNLALFGERLG
LVGHSPSSASLNFLHALEVMFKSTVQL
MFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF
SRPQQYTSIVAELLLN
AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAAS
ISEHP
QKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVRVFLYSLGRNPA
LFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE
TLTQEDIKMVYSFILR
PSMCPLLTFRAIN

# Metabolic_Enzyme_1_Number_of_Residues:
503

# Metabolic_Enzyme_1_Molecular_Weight:
57530

# Metabolic_Enzyme_1_Theoretical_pI:
9.42

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_1_Specific_Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB

# Metabolic_Enzyme_1_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_1_Reaction:
a steroid + reduced adrenal ferredoxin + O2 = an 11beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_1_Signals:
1-23

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.14.15.4

# Metabolic_Enzyme_1_GenBank_ID_Protein:
181333

# Metabolic_Enzyme_1_SwissProt_ID:
C11B1_HUMAN (P15538)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
CYP11B1

# Metabolic_Enzyme_1_Geneatlas_id:
CYP11B1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2591

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_1_Gene_Sequence:
>1512 bp

ATGGCACTCAGGGCAAAGGCAGAGGTGTGCATGGCAGTGCCCTGGCTGTCCCTGCAAAG
GGCACAGGCAC
TGGGCACGAGAGCCGCCCGGGTCCCCAGGACAGTGCTGCCCTTTGAAG
CCATGCCCCGGCGTCCAGGCAA
CAGGTGGCTGAGGCTGCTGCAGATCTGGAGGGAGCAG
GGTTATGAGGACCTGCACCTGGAAGTACACCAG
ACCTTCCAGGAACTGGGGCCCATTTT
CAGGTACGATTTGGGAGGAGCAGGCATGGTGTGTGTGATGCTGC
CGGAGGACGTGGAGA
AGCTGCAACAGGTGGACAGCCTGCATCCCCACAGGATGAGCCTGGAGCCCTGGGT
GGCC
TACAGACAACATCGTGGGCACAAATGTGGCGTGTTCTTGCTGAATGGGCCTGAATGGCGC
TTCAAC
CGATTGCGGCTGAATCCAGAAGTGCTGTCGCCCAACGCTGTGCAGAGGTTCCT
CCCGATGGTGGATGCAG
TGGCCAGGGACTTCTCCCAGGCCCTGAAGAAGAAGGTGCTGC
AGAACGCCCGGGGGAGCCTGACCCTGGA
CGTCCAGCCCAGCATCTTCCACTACACCATA
GAAGCCAGCAACTTGGCTCTTTTTGGAGAGCGGCTGGGC
CTGGTTGGCCACAGCCCCAG
TTCTGCCAGCCTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCA
CCGTCCAGC
TCATGTTCATGCCCAGGAGCCTGTCTCGCTGGACCAGCCCCAAGGTGTGGAAGGAGCACT
T
TGAGGCCTGGGACTGCATCTTCCAGTACGGCGACAACTGTATCCAGAAAATCTATCAG
GAACTGGCCTTC
AGCCGCCCTCAACAGTACACCAGCATCGTGGCGGAGCTCCTGTTGAA
TGCGGAACTGTCGCCAGATGCCA
TCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCG
TGGACACGACGGTGTTTCCCTTGCTGATGACGCT
CTTTGAGCTGGCTCGGAACCCCAAC
GTGCAGCAGGCCCTGCGCCAGGAGAGCCTGGCCGCCGCAGCCAGC
ATCAGTGAACATCC
CCAGAAGGCAACCACCGAGCTGCCCTTGCTGCGTGCGGCCCTCAAGGAGACCTTGC
GGC
TCTACCCTGTGGGTCTGTTTCTGGAGCGAGTGGCGAGCTCAGACTTGGTGCTTCAGAACT
ACCACAT
CCCAGCTGGGACATTGGTGCGCGTGTTCCTCTACTCTCTGGGTCGCAACCCC
GCCTTGTTCCCGAGGCCT
GAGCGCTATAACCCCCAGCGCTGGCTAGACATCAGGGGCTC
CGGCAGGAACTTCTACCACGTGCCCTTTG
GCTTTGGCATGCGCCAGTGCCTTGGGCGGC
GCCTGGCAGAGGCAGAGATGCTGCTGCTGCTGCACCATGT
GCTGAAACACCTCCAGGTG
GAGACACTAACCCAAGAGGACATAAAGATGGTCTACAGCTTCATATTGAGG
CCCAGCAT
GTGCCCCCTCCTCACCTTCAGAGCCATCAACTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M32879

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_1_Locus:
8q21

# Metabolic_Enzyme_1_SNPs:
rs4541; rs4534; rs5288; rs5294; rs6405; rs34620645; rs6410; rs5283; rs5290; rs6403; rs6419; rs34570566; rs5316; rs5284; rs5299; rs5301; rs7003319; rs5304; rs1134096; rs5303; rs1134095; rs5017238; rs5297; rs4736312; rs5300; rs3802229; rs6389; rs9657021; rs4310186; rs6388; rs7822986; rs6471570; rs6387; rs4535; rs4736315; rs10956991; rs5295; rs6393; rs7814006; rs7814020; rs7818826; rs4609179; rs7818953; rs11775687; rs6390; rs6398; rs10105643; rs6400; rs6392; rs12674916; rs7833415; rs6411; rs6391; rs12542799; rs6402; rs6395; rs6422; rs6409; rs5280; rs4736346; rs10093618; rs4736311; rs4471016; rs4313136; rs5292; rs28934586; rs5287; rs5282; rs4998901; rs5291; rs4998896; rs6407; rs4998898; rs4998902; rs4998900; rs4998899; rs4998903; rs4998897; rs9657022; rs5296; rs4998895; rs1137481; rs1137484; rs5302; rs35673190; rs5017237; rs1137480; rs1137485; rs12543598; rs5298; rs34274727; rs1137488; rs5017240; rs5027479; rs1137486; rs1137483; rs5027480; rs5017239; rs1137487; rs5027478; rs4998894; rs9657020; rs4999335; rs4236887; rs5286; rs13250178; rs4999334; rs35378570; rs28551743; rs36004897; rs5895733; rs34698173; rs12114482; rs28418310; rs10098023; rs4464947; rs4548164; rs4581033; rs4736308; rs4736309; rs4736310; rs4736349; rs4736350; rs6995180; rs7005638; rs7016088; rs7016594

# Metabolic_Enzyme_1_General_References:
2592361; 2401360; 7903314; 3499608; 1741400; 2022736; 9302260; 10599751; 10391209; 10391210

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5737

# Metabolic_Enzyme_2_Name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II

# Metabolic_Enzyme_2_Synonyms:
3- beta-HSD II[Includes: 3-beta-hydroxy-Delta(5-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta-isomerase; Delta- 5-3-ketosteroid isomerase]

# Metabolic_Enzyme_2_Gene_Name:
HSD3B2

# Metabolic_Enzyme_2_Protein_Sequence:
>3 betahydroxysteroid dehydrogenase/Delta 5>4isomerase type II
MGWSCLVTGAGGLLGQRIVRLLVEEKELKEIRALDKAFRPELREEFSKLQNRTKLTVLEG
DILDEPFLKR
ACQDVSVVIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVF
IYTSSIEVAGPNSYKEIIQNG
HEEEPLENTWPTPYPYSKKLAEKAVLAANGWNLKNGDT
LYTCALRPTYIYGEGGPFLSASINEALNNNGI
LSSVGKFSTVNPVYVGNVAWAHILALR
ALRDPKKAPSVRGQFYYISDDTPHQSYDNLNYILSKEFGLRLD
SRWSLPLTLMYWIGFL
LEVVSFLLSPIYSYQPPFNRHTVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQ
KTVEW
VGSLVDRHKETLKSKTQ

# Metabolic_Enzyme_2_Number_of_Residues:
372

# Metabolic_Enzyme_2_Molecular_Weight:
42053

# Metabolic_Enzyme_2_Theoretical_pI:
8.17

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, transposing C=C bonds
Function:  steroid delta-isomerase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  3-beta-hydroxy-delta5-steroid dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_2_Specific_Function:
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids

# Metabolic_Enzyme_2_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_2_Reaction:
A 3-oxo-delta5-steroid = a 3-oxo-delta4-steroid

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01073:3Beta_HSD

# Metabolic_Enzyme_2_Signals:
1-15

# Metabolic_Enzyme_2_Transmembrane_Regions:
287-307

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.1.145;EC 5.3.3.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
184401

# Metabolic_Enzyme_2_SwissProt_ID:
3BHS2_HUMAN (P26439)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
HSD3B2

# Metabolic_Enzyme_2_Geneatlas_id:
HSD3B2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:5218

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein. Mitochondrion; mitochondrial membrane; single-pass membrane protein

# Metabolic_Enzyme_2_Gene_Sequence:
>1119 bp

ATGGGCTGGAGCTGCCTTGTGACAGGAGCAGGAGGGCTTCTGGGTCAGAGGATCGTCCG
CCTGTTGGTGG
AAGAGAAGGAACTGAAGGAGATCAGGGCCTTGGACAAGGCCTTCAGAC
CAGAATTGAGAGAGGAATTTTC
TAAGCTCCAGAACAGGACCAAGCTGACTGTACTTGAA
GGAGACATTCTGGATGAGCCATTCCTGAAAAGA
GCCTGCCAGGACGTCTCGGTCGTCAT
CCACACCGCCTGTATCATTGATGTCTTTGGTGTCACTCACAGAG
AGTCCATCATGAATG
TCAATGTGAAAGGTACCCAGCTACTGTTGGAGGCCTGTGTCCAAGCCAGTGTGCC
AGTC
TTCATCTACACCAGTAGCATAGAGGTAGCCGGGCCCAACTCCTACAAGGAAATCATCCAG
AACGGC
CACGAAGAAGAGCCTCTGGAAAACACATGGCCCACTCCATACCCGTACAGCAA
AAAGCTTGCTGAGAAGG
CTGTGCTGGCGGCTAATGGGTGGAATCTAAAAAATGGTGATA
CCTTGTACACTTGTGCGTTAAGACCCAC
ATATATCTATGGGGAAGGAGGCCCATTCCTT
TCTGCCAGTATAAATGAGGCCCTGAACAACAATGGGATC
CTGTCAAGTGTTGGAAAGTT
CTCTACAGTCAACCCAGTCTATGTTGGCAACGTGGCCTGGGCCCACATTC
TGGCCTTGA
GGGCTCTGCGGGACCCCAAGAAGGCCCCAAGTGTCCGAGGTCAATTCTATTACATCTCAG
A
TGACACGCCTCACCAAAGCTATGATAACCTTAATTACATCCTGAGCAAAGAGTTTGGC
CTCCGCCTTGAT
TCCAGATGGAGCCTTCCTTTAACCCTGATGTACTGGATTGGCTTCCT
GCTGGAAGTAGTGAGCTTCCTAC
TCAGCCCAATTTACTCCTATCAACCCCCCTTCAACC
GCCACACAGTCACATTATCAAATAGTGTGTTCAC
CTTCTCTTACAAGAAGGCTCAGCGA
GATCTGGCGTATAAGCCACTCTACAGCTGGGAGGAAGCCAAGCAG
AAAACCGTGGAGTG
GGTTGGTTCCCTTGTGGACCGGCACAAGGAGACCCTGAAGTCCAAGACTCAGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M67466

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_2_Locus:
1p13.1

# Metabolic_Enzyme_2_SNPs:
rs4986954; rs6211; rs35887327; rs6207; rs33926546; rs34412477; rs33932258; rs1819698; rs1361530; rs9282704; rs6208; rs6210; rs9282703; rs3753258; rs12411115; rs2854961; rs33920337; rs17023577; rs12044792; rs2854964; rs10923817; rs3765948; rs12411080; rs2854963; rs2793133; rs7411891; rs2854962; rs2793132; rs6676988; rs4659174; rs12062744; rs33952871; rs33963971; rs4659175; rs35983269; rs34492690; rs34177617; rs35954381; rs35344469; rs35569514; rs9282705; rs28943871; rs35613222; rs28934880; rs35486059; rs34562248; rs714748; rs10591825; rs10616581; rs34234813; rs12741109; rs3057393; rs35081017; rs3820030; rs6692175; rs10616582; rs12742063; rs12404035; rs12741125; rs36021225; rs36022499; rs5777392; rs12723698; rs35507723; rs35448442; rs35847875; rs34282330; rs10754396; rs10923815; rs10923819; rs10923820; rs11579951; rs12022215; rs12403392; rs12404131; rs12405488; rs1341018; rs17023564; rs2185556; rs2185557; rs6661603; rs947129

# Metabolic_Enzyme_2_General_References:
1944309; 1741954; 8316254; 7833923; 8126127; 7962268; 8185809; 8060486; 7893703; 7633426; 7633460; 7608265; 9719627; 10599696; 10651755; 10843183; 12050213

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5738

# Metabolic_Enzyme_3_Name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I

# Metabolic_Enzyme_3_Synonyms:
3- beta-HSD I; Trophoblast antigen FDO161G[Includes: 3-beta-hydroxy- Delta(5-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta- isomerase; Delta-5-3-ketosteroid isomerase]

# Metabolic_Enzyme_3_Gene_Name:
HSD3B1

# Metabolic_Enzyme_3_Protein_Sequence:
>3 betahydroxysteroid dehydrogenase/Delta 5>4isomerase type I
MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELREEFSKLQNKTKLTVLE
GDILDEPFLK
RACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPV
FIYTSSIEVAGPNSYKEIIQN
GHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGG
TLYTCALRPMYIYGEGSRFLSASINEALNNNG
ILSSVGKFSTVNPVYVGNVAWAHILAL
RALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRL
DSRWSFPLSLMYWIGF
LLEIVSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAK
QKTVE
WVGSLVDRHKETLKSKTQ

# Metabolic_Enzyme_3_Number_of_Residues:
373

# Metabolic_Enzyme_3_Molecular_Weight:
42252

# Metabolic_Enzyme_3_Theoretical_pI:
8.98

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, transposing C=C bonds
Function:  steroid delta-isomerase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  3-beta-hydroxy-delta5-steroid dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_3_Specific_Function:
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids

# Metabolic_Enzyme_3_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_3_Reaction:
A 3-oxo-delta5-steroid = a 3-oxo-delta4-steroid

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01073:3Beta_HSD

# Metabolic_Enzyme_3_Signals:
1-13

# Metabolic_Enzyme_3_Transmembrane_Regions:
288-308

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.1.1.145;EC 5.3.3.1

# Metabolic_Enzyme_3_GenBank_ID_Protein:
306889

# Metabolic_Enzyme_3_SwissProt_ID:
3BHS1_HUMAN (P14060)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
HSD3B1

# Metabolic_Enzyme_3_Geneatlas_id:
HSD3B1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:5217

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein. Mitochondrion; mitochondrial membrane; single-pass membrane protein

# Metabolic_Enzyme_3_Gene_Sequence:
>1122 bp

ATGACGGGCTGGAGCTGCCTTGTGACAGGAGCAGGAGGGTTTCTGGGACAGAGGATCAT
CCGCCTCTTGG
TGAAGGAGAAGGAGCTGAAGGAGATCAGGGTCTTGGACAAGGCCTTCG
GACCAGAATTGAGAGAGGAATT
TTCTAAACTCCAGAACAAGACCAAGCTGACAGTGCTG
GAAGGAGACATTCTGGATGAGCCATTCCTGAAG
AGAGCCTGCCAGGACGTCTCGGTCAT
CATCCACACCGCCTGTATCATTGATGTCTTCGGTGTCACTCACA
GAGAGTCTATCATGA
ATGTCAATGTGAAAGGTACCCAGCTCCTGTTAGAGGCCTGTGTCCAAGCTAGTGT
GCCA
GTCTTCATCTACACCAGTAGCATAGAGGTAGCCGGGCCCAACTCCTACAAGGAAATCATC
CAGAAT
GGCCATGAAGAAGAGCCTCTGGAAAACACATGGCCCGCTCCATACCCACACAG
CAAAAAGCTTGCTGAGA
AGGCTGTACTGGCGGCTAACGGGTGGAATCTGAAAAACGGCG
GCACCCTGTACACTTGTGCCTTACGACC
CATGTATATCTATGGGGAAGGAAGCCGATTC
CTTTCTGCTAGTATAAACGAGGCCCTGAACAACAATGGG
ATCCTGTCAAGTGTTGGAAA
GTTCTCCACTGTTAACCCAGTCTATGTTGGCAATGTGGCCTGGGCCCACA
TTCTGGCCT
TGAGGGCCCTGCAGGACCCCAAGAAGGCCCCAAGCATCCGAGGACAGTTCTACTATATCT
C
AGATGACACGCCTCACCAAAGCTATGATAACCTTAATTACACCCTGAGCAAAGAGTTC
GGCCTCCGCCTT
GATTCCAGATGGAGCTTTCCTTTATCCCTGATGTATTGGATTGGCTT
CCTGCTGGAAATAGTGAGCTTCC
TACTCAGGCCAATTTACACCTATCGACCGCCCTTCA
ACCGCCACATAGTCACATTGTCAAATAGCGTATT
CACCTTCTCTTATAAGAAGGCTCAG
CGAGATCTGGCGTATAAGCCACTCTACAGCTGGGAGGAAGCCAAG
CAGAAAACGGTGGA
GTGGGTTGGTTCCCTTGTGGACCGGCACAAGGAGACCCTGAAGTCCAAGACTCAGT
GA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M27137

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
2779585; 2139411; 2082186; 2243100; 1920284; 1401999; 10391209

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5809

# Metabolic_Enzyme_4_Name:
Cytochrome P450 21

# Metabolic_Enzyme_4_Synonyms:
Cytochrome P450 XXI; Steroid 21- hydroxylase; 21-OHase; P450-C21; P-450c21; P450-C21B

# Metabolic_Enzyme_4_Gene_Name:
CYP21A2

# Metabolic_Enzyme_4_Protein_Sequence:
>Cytochrome P450 21
MLLLGLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYR
LHLGLQDVVV
LNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDLSLGDYSLLWKAH
KKLTRSALLLGIRDSMEPVVE
QLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFG
DKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVD
VIPFLRFFPNPGLRRLKQAIEKRDHIV
EMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGH
VHMAAVDLLIGGTETT
ANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIA
EVLRL
RPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKN
SRALA
FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQ
PFQVRLQPRGMGAHSP
GQNQ

# Metabolic_Enzyme_4_Number_of_Residues:
494

# Metabolic_Enzyme_4_Molecular_Weight:
55888

# Metabolic_Enzyme_4_Theoretical_pI:
7.90

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_4_Specific_Function:
Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids

# Metabolic_Enzyme_4_Pathway:
map00140  C21-Steroid hormone metabolism

# Metabolic_Enzyme_4_Reaction:
a steroid + AH2 + O2 = a 21-hydroxysteroid + A + H2O

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_4_Signals:
1-15

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.14.99.10

# Metabolic_Enzyme_4_GenBank_ID_Protein:
181290

# Metabolic_Enzyme_4_SwissProt_ID:
CP21A_HUMAN (P08686)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CYP21A2

# Metabolic_Enzyme_4_Geneatlas_id:
CYP21A2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:2600

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein

# Metabolic_Enzyme_4_Gene_Sequence:
>102 bp

CGCATGAGAGCCCAGCCCGGCACCCCTGTGGCCATTGAGGAGGAATTCTCTCTCCTCAC
CTGCAGCATCA
TCTGTTACCTCACCTTCGGAGACAAGATCAAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M19711

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_4_Locus:
6p21.3

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
3487786; 3486422; 3038528; 1406709; 3871526; 3497399; 1864962; 8081391; 3257825; 2303461; 1937474; 2072928; 1644925; 1406699; 1496017; 8478006; 7749410; 9067760; 9187661; 8989258; 9580109; 9497336; 10094562; 10408778; 10408786; 10051010; 10391209; 12788866; 12915679

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5991

# Metabolic_Enzyme_5_Name:
Corticosteroid 11-beta-dehydrogenase isozyme 2

# Metabolic_Enzyme_5_Synonyms:
11-DH2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-beta-HSD2; NAD- dependent 11-beta-hydroxysteroid dehydrogenase

# Metabolic_Enzyme_5_Gene_Name:
HSD11B2

# Metabolic_Enzyme_5_Protein_Sequence:
>Corticosteroid 11betadehydrogenase isozyme 2
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV
LAAAGWIALS
RLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSP
GAIELRTCCSPRLRLLQMDLT
KPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAE
LSPVATFRSCMEVNFFGALELTKGLLPLLRSS
RGRIVTVGSPAGDMPYPCLGAYGTSKA
AVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRK
QLLLANLPQELLQAYG
KDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFI
HYYLP
EGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR

# Metabolic_Enzyme_5_Number_of_Residues:
405

# Metabolic_Enzyme_5_Molecular_Weight:
44127

# Metabolic_Enzyme_5_Theoretical_pI:
9.58

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids

# Metabolic_Enzyme_5_Pathway:
Not Available

# Metabolic_Enzyme_5_Reaction:
Not Available

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_5_Signals:
1-21

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.1.1.146

# Metabolic_Enzyme_5_GenBank_ID_Protein:
565082

# Metabolic_Enzyme_5_SwissProt_ID:
DHI2_HUMAN (P80365)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
HSD11B2

# Metabolic_Enzyme_5_Geneatlas_id:
HSD11B2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:5209

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Microsome

# Metabolic_Enzyme_5_Gene_Sequence:
>1218 bp

ATGGAGCGCTGGCCTTGGCCGTCGGGCGGCGCCTGGCTGCTCGTGGCTGCCCGCGCGCT
GCTGCAGCTGC
TGCGCTCAGACCTGCGTCTGGGCCGCCCGCTGCTGGCGGCGCTGGCGC
TGCTGGCCGCGCTCGACTGGCT
GTGCCAGCGCCTGCTGCCCCCGCCGGCCGCACTCGCC
GTGCTGGCCGCCGCCGGCTGGATCGCGTTGTCC
CGCCTGGCGCGCCCGCAGCGCCTGCC
GGTGGCCACTCGCGCGGTGCTCATCACCGGCTGTGACTCTGGTT
TTGGCAAGGAGACGG
CCAAGAAACTGGACTCCATGGGCTTCACGGTGCTGGCCACCGTATTGGAGTTGAA
CAGC
CCCGGTGCCATCGAGCTGCGTACCTGCTGCTCCCCTCGCCTAAGGCTGCTGCAGATGGAC
CTGACC
AAACCAGGAGACATTAGCCGCTTGCTAGAGTTCACCAAGGCCCACACCACCAG
CACCGGCCTGTGGGGCC
TCGTCAACAACGCAGGCCACAATGAAGTAGTTGCTGATGCGG
AGCTGTCTCCAGTGGCCACTTTCCGTAG
CTGCATGGAGGTGAATTTCTTTGGCGCGCTC
GAGCTGACCAAGGGCCTCCTGCCCCTGCTGCGCAGCTCA
AGGGGCCGCATCGTGACTGT
GGGGAGCCCAGCGGGGGACATGCCATATCCGTGCTTGGGGGCCTATGGAA
CCTCCAAAG
CGGCCGTGGCGCTACTCATGGACACATTCAGCTGTGAACTCCTTCCCTGGGGGGTCAAGG
T
CAGCATCATCCAGCCTGGCTGCTTCAAGACAGAGTCAGTGAGAAACGTGGGTCAGTGG
GAAAAGCGCAAG
CAATTGCTGCTGGCCAACCTGCCTCAAGAGCTGCTGCAGGCCTACGG
CAAGGACTACATCGAGCACTTGC
ATGGGCAGTTCCTGCACTCGCTACGCCTGGCCATGT
CCGACCTCACCCCAGTTGTAGATGCCATCACAGA
TGCGCTGCTGGCAGCTCGGCCCCGC
CGCCGCTATTACCCCGGCCAGGGCCTGGGGCTCATGTACTTCATC
CACTACTACCTGCC
TGAAGGCCTGCGGCGCCGCTTCCTGCAGGCCTTCTTCATCAGTCACTGTCTGCCTC
GAG
CACTGCAGCCTGGCCAGCCTGGCACTACCCCACCACAGGACGCAGCCCAGGACCCAAACC
TGAGCCC
CGGCCCTTCCCCAGCAGTGGCTCGGTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U14631

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_5_Locus:
16q22

# Metabolic_Enzyme_5_SNPs:
rs5479; rs5480; rs9923709; rs13329942; rs17855911; rs28934592; rs28934594; rs13306425; rs17853703; rs28934591; rs28934593; rs1139495; rs2855410; rs5481; rs2549646; rs35257037; rs2855408; rs12935213; rs12919979; rs12934342; rs12934368; rs2549644; rs12935253; rs12919584; rs12934351; rs28464206; rs12933947; rs34076422; rs2549647; rs11413878; rs2549645; rs12934369; rs13306424; rs2855411; rs2855407; rs2549643; rs2549641; rs2855406; rs2911119; rs2855405; rs2549642; rs2925933; rs28373713; rs12918538; rs2911120; rs1053099; rs1053271; rs11860837; rs1213164; rs12596882; rs16957430; rs1802795; rs2279023; rs34389524; rs4360931; rs6499129; rs8056260; rs9922476; rs9922624; rs9936153; rs9936306; rs9940901

# Metabolic_Enzyme_5_General_References:
7859916; 8530071; 8611140; 11350956; 2889032; 7608290; 7593417; 7670488; 9398712; 9683587; 9661590; 9851783; 9707624; 10489390; 10523339; 11238516

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5808

# Metabolic_Enzyme_6_Name:
Cytochrome P450 11B2, mitochondrial precursor

# Metabolic_Enzyme_6_Synonyms:
CYPXIB2; P-450Aldo; Aldosterone synthase; ALDOS; Aldosterone-synthesizing enzyme; Steroid 18-hydroxylase; P-450C18

# Metabolic_Enzyme_6_Gene_Name:
CYP11B2

# Metabolic_Enzyme_6_Protein_Sequence:
>Cytochrome P450 11B2, mitochondrial precursor
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN

# Metabolic_Enzyme_6_Number_of_Residues:
503

# Metabolic_Enzyme_6_Molecular_Weight:
57561

# Metabolic_Enzyme_6_Theoretical_pI:
9.78

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_6_Specific_Function:
Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone

# Metabolic_Enzyme_6_Pathway:
map00140  C21-Steroid hormone metabolism;
GENES       HSA: 1584(CYP11B1) 1585(CYP11B2);
            MMU: 13072(Cyp11b2) 223628(LOC223628);
            RNO: 24293(Cyp11b1) 24294(Cyp11b2) 353498(Cyp11b3)

# Metabolic_Enzyme_6_Reaction:
corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.14.15.4;EC 1.14.15.5

# Metabolic_Enzyme_6_GenBank_ID_Protein:
181340

# Metabolic_Enzyme_6_SwissProt_ID:
C11B2_HUMAN (P19099)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
CYP11B2

# Metabolic_Enzyme_6_Geneatlas_id:
CYP11B2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:2592

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_6_Gene_Sequence:
>1512 bp
ATGGCACTCAGGGCAAAGGCAGAGGTGTGCGTGGCAGCGCCCTGGCTGTGCCTGCAAAGG
GCACGGGCACTGGGCACTAGAGCCGCTCGGGCCCCTAGGACGGTGCTGCCGTTTGAAGCC
ATGCCCCAGCATCCAGGCAACAGGTGGCTGAGGCTGCTGCAGATGTGGAGGGAGCAGGGT
TATGAGCACCTGCACCTGGAGATGCACCAGACCTTCCAGGAGCTGGGGCCCATTTTCAGG
TACAACTTGGGAGGACCACGCATGGTGTGTGTGATGCTGCCGGAGGATGTGGAGAAGCTG
CAACAGGTGGACAGCCTGCATCCCTGCAGGATGATCCTGGAGCCCTGGGTGGCCATCAGA
CAACATCGTGGGCACAAATGTGGCGTGTTCTTGTTGAATGGGCCTGAATGGCGCTTCAAC
CGATTGCGGCTGAACCCAGATGTGCTGTCGCCCAAGGCCGTGCAGAGGTTCCTCCCGATG
GTGGATGCAGTGGCCAGGGACTTTTCCCAGGCCCTGAGGAAGAAGGTGCTGCAGAACGCC
CGGGGGAGCCTGACCCTGGACGTCCAGCCCAGCATCTTCCACTACACCATAGAAGCCAGC
AACTTAGCTCTTTTTGGAGAGCGGCTGGGCCTGGTTGGCCACAGCCCCAGTTCTGCCAGC
CTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCACCGTCCAGCTCATGTTCATG
CCCAGGAGCCTGTCTCGCTGGATCAGCCCCAAGGTGTGGAAGGAGCACTTTGAGGCCTGG
GACTGCATCTTCCAGTACGGTGACAACTGTATCCAGAAAATCTACCAGGAACTGGCCTTC
AACCGCCCTCAACACTACACAGGCATCGTGGCAGAGCTCCTGTTGAAGGCGGAACTGTCA
CTAGAAGCCATCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCGTGGACACGACAGCG
TTTCCGTTGCTGATGACGCTCTTTGAGCTGGCTCGGAACCCCGACGTGCAGCAGATCCTG
CGCAAGGAGAGCCTGGCCGCCGCAGCCAGCATCAGTGAACATCCCCAGAAGGCAACCACC
GAGCTGCCCTTGCTGCGGGCGGCCCTCAAGGAGACCTTGAGGCTCTACCCTGTGGGTCTG
TTTTTGGAGCGAGTGGTGAGCTCAGACTTGGTGCTTCAGAACTACCACATCCCAGCTGGG
ACATTGGTACAGGTTTTCCTCTACTCGCTGGGTCGCAATGCCGCCTTGTTCCCGAGGCCT
GAGCGGTATAATCCCCAGCGCTGGCTAGACATCAGGGGCTCCGGCAGGAACTTGCACCAC
GTGCCCTTTGGCTTTGGCATGCGCCAGTGCCTCGGGCGGCGCCTGGCAGAGGCAGAGATG
CTGCTGCTGCTGCACCACGTGCTGAAGCGCTTCCTGGTGGAGACACTAACTCAAGAGGAC
ATAAAGATGGTCTACAGCTTCATATTGAGGCCTGGCACGTCCCCCCTCCTCACTTTCAGA
GCGATTAACTAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M32881

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_6_Locus:
8q21-q22

# Metabolic_Enzyme_6_SNPs:
rs4545; rs4544; rs6441; rs4537; rs4539; rs5312; rs6438; rs4536; rs4543; rs4538; rs5310; rs5313; rs5281; rs4546; rs3802230; rs3839864; rs3097; rs3802228; rs3201271; rs6431; rs6435; rs7461740; rs6397; rs6432; rs6429; rs11781816; rs6421; rs10107682; rs10090630; rs4072020; rs6399; rs10096239; rs6396; rs10099658; rs4736320; rs6433; rs7836572; rs13276226; rs5307; rs10099052; rs6418; rs6434; rs6416; rs10086846; rs12679242; rs6414; rs10110732; rs6415; rs11779229; rs6394; rs5306; rs6413; rs10090037; rs7463212; rs1799998; rs6471583; rs11781082; rs10087214; rs6992689; rs11991278; rs6440; rs12542987; rs5305; rs28931609; rs5315; rs5317; rs28930074; rs9297975; rs3201269; rs33921450; rs7463238; rs35574522; rs28390200; rs28491316; rs3201272; rs33936656; rs13257266; rs13268153; rs28531895; rs33911914; rs28361356; rs35733998; rs5895735; rs35490512; rs28526467; rs36018151; rs34144193; rs6436; rs28366703; rs13257680; rs1574565; rs5314; rs35909170; rs28394055; rs13263682; rs28615142; rs28497862; rs13252628; rs13257267; rs28659182; rs13268025; rs5895734; rs10956996; rs34951350; rs7463148; rs10623281; rs13254375; rs34884498; rs7464883; rs1800534; rs10096393; rs10108843; rs11775009; rs12546357; rs13267320; rs35431302; rs4379428; rs4736317; rs4736318; rs4736319; rs4736355; rs4736356; rs4736357; rs4736358; rs4736359; rs4736360; rs6471580; rs6471581; rs6471586; rs6651273; rs6981918; rs6987382; rs7004863; rs7011830; rs7011889; rs7011901; rs7016924; rs7460125; rs7819943; rs7820667; rs7821838; rs7824229; rs7828967; rs7831617; rs7844961; rs9643358

# Metabolic_Enzyme_6_General_References:
2592361; 2256920; 1594605; 1346492; 8439335; 9177280; 9625333; 9814506; 9931115; 10391209; 10391210; 11238478; 12788848

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5992

# Metabolic_Enzyme_7_Name:
Corticosteroid 11-beta-dehydrogenase isozyme 1

# Metabolic_Enzyme_7_Synonyms:
11-DH; 11-beta-hydroxysteroid dehydrogenase 1; 11-beta-HSD1

# Metabolic_Enzyme_7_Gene_Name:
HSD11B1

# Metabolic_Enzyme_7_Protein_Sequence:
>Corticosteroid 11betadehydrogenase isozyme 1
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKET
LQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILN
HITNTSLNLFHDDIHHVRKSM
EVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYP
MVAAYSASKFALDGFFSSIRKEYSVSRVNVSI
TLCVLGLIDTETAMKAVSGIVHMQAAP
KEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLY
STSYNMDRFINK

# Metabolic_Enzyme_7_Number_of_Residues:
292

# Metabolic_Enzyme_7_Molecular_Weight:
32401

# Metabolic_Enzyme_7_Theoretical_pI:
8.77

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol

# Metabolic_Enzyme_7_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_7_Reaction:
an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_7_Signals:
1-23

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.1.1.146

# Metabolic_Enzyme_7_GenBank_ID_Protein:
179475

# Metabolic_Enzyme_7_SwissProt_ID:
DHI1_HUMAN (P28845)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
HSD11B1

# Metabolic_Enzyme_7_Geneatlas_id:
HSD11B1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:5208

# Metabolic_Enzyme_7_PDB_ID:
1XU9

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass type II membrane protein

# Metabolic_Enzyme_7_Gene_Sequence:
>879 bp

ATGGCTTTTATGAAAAAATATCTCCTCCCCATTCTGGGGCTCTTCATGGCCTACTACTA
CTATTCTGCAA
ACGAGGAATTCAGACCAGAGATGCTCCAAGGAAAGAAAGTGATTGTCA
CAGGGGCCAGCAAAGGGATCGG
AAGAGAGATGGCTTATCATCTGGCGAAGATGGGAGCC
CATGTGGTGGTGACAGCGAGGTCAAAAGAAACT
CTACAGAAGGTGGTATCCCACTGCCT
GGAGCTTGGAGCAGCCTCAGCACACTACATTGCTGGCACCATGG
AAGACATGACCTTCG
CAGAGCAATTTGTTGCCCAAGCAGGAAAGCTCATGGGAGGACTAGACATGCTCAT
TCTC
AACCACATCACCAACACTTCTTTGAATCTTTTTCATGATGATATTCACCATGTGCGCAAA
AGCATG
GAAGTCAACTTCCTCAGTTACGTGGTCCTGACTGTAGCTGCCTTGCCCATGCT
GAAGCAGAGCAATGGAA
GCATTGTTGTCGTCTCCTCTCTGGCTGGGAAAGTGGCTTATC
CAATGGTTGCTGCCTATTCTGCAAGCAA
GTTTGCTTTGGATGGGTTCTTCTCCTCCATC
AGAAAGGAATATTCAGTGTCCAGGGTCAATGTATCAATC
ACTCTCTGTGTTCTTGGCCT
CATAGACACAGAAACAGCCATGAAGGCAGTTTCTGGGATAGTCCATATGC
AAGCAGCTC
CAAAGGAGGAATGTGCCCTGGAGATCATCAAAGGGGGAGCTCTGCGCCAAGAAGAAGTGT
A
TTATGACAGCTCACTCTGGACCACTCTTCTGATCAGAAATCCATGCAGGAAGATCCTG
GAATTTCTCTAC
TCAACGAGCTATAATATGGACAGATTCATAAACAAGTAG

# Metabolic_Enzyme_7_GenBank_ID_Gene:
M76665

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_7_Locus:
1q32-q41

# Metabolic_Enzyme_7_SNPs:
rs2235543; rs846911; rs846909; rs6752; rs4844880; rs861762; rs11808911; rs760952; rs11804533; rs10863782; rs3753519; rs4844881; rs846910; rs10082169; rs860185; rs846914; rs11590066; rs760951; rs2357075; rs10082248; rs11805981; rs6656906; rs11119326; rs12565406; rs10863781; rs7543025; rs968033; rs932335; rs1474654; rs2884090; rs2282738; rs846906; rs11119328; rs3766619; rs3766618; rs1474655; rs2236902; rs1000283; rs11808690; rs7539852; rs6679099; rs11811440; rs9430013; rs12040780; rs9430014; rs12086634; rs6672256; rs2298930; rs11119327; rs11807619; rs2282740; rs11806703; rs9430012; rs4314885; rs11799643; rs12116437; rs631923; rs2236904; rs11487867; rs4844890; rs12060922; rs11119333; rs10863783; rs17015069; rs12024779; rs17015053; rs1000282; rs2236903; rs12059226; rs11119332; rs12138452; rs12561766; rs1415542; rs11119330; rs2282739; rs4844488; rs11119331; rs846908; rs701950; rs11119325; rs41283132; rs1047202; rs17850941; rs35932418; rs41283130; rs34506121; rs36212444; rs12039840; rs3059689; rs35096215; rs34785756; rs5780532; rs35689564; rs35479221; rs7529376; rs12041309; rs13306420; rs36212449; rs34533406; rs12138389; rs846915; rs12734051; rs12757955; rs13306419; rs36212447; rs35179819; rs36212448; rs13306421; rs12128216; rs10863780; rs12030418; rs12047442; rs7528902; rs34580232; rs12143228; rs1883442; rs35492868; rs3920499; rs12034329; rs13306422; rs12063265; rs34578769; rs34407603; rs11485195; rs12060420; rs12097899; rs34038823; rs12759302; rs35966136; rs7547027; rs35349406; rs12094117; rs13306423; rs28895393; rs34755409; rs35206856; rs3059693; rs17015042; rs5780533; rs5780534; rs11119329; rs4844889; rs11464749; rs12090931; rs34148285; rs34574844; rs11802270; rs35890324; rs34866038; rs1890085; rs11487866; rs12745309; rs10614817; rs35939947; rs34941680; rs2282741; rs2236905; rs11591045; rs34205549; rs35603025; rs11119334; rs34727634; rs10863785; rs11576775; rs12123431; rs1337529; rs1337532; rs17015076; rs17015078; rs17317033; rs17389016; rs2064148; rs2205985; rs35394268; rs3765240; rs4393158; rs4545339; rs4844891; rs6540547; rs6694238; rs7513155; rs7517562; rs7528642; rs7532021; rs7532324; rs7548781; rs7550346; rs846907; rs9430016

# Metabolic_Enzyme_7_General_References:
1885595

# Metabolic_Enzyme_7_References:
Not Available

End of HMDB00063

Beginning of HMDB00064
# Accession_No:
HMDB00064

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-10 09:36:53

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Creatine

# Description:
An amino acid that occurs in vertebrate tissues and in urine.  In muscle tissue, creatine generally occurs as phosphocreatine.  Creatine is excreted as CREATININE in the urine. Creatine functions as part of the cell's energy shuttle. The high energy phosphate group of ATP is transferred to creatine to form phosphocreatine in the following reaction: Cr + ATP <-> PCr + ADP. This reaction is reversibly catalyzed by creatine kinase. In the human body creatine is synthesized mainly in the liver by the use of parts from three different amino acids - arginine, glycine, and methionine. 95% of it is later stored in the skeletal muscles, with the rest in the brain, heart, testes.

# Synonyms:
((amino(imino)methyl)(methyl)amino)acetate; ((amino(imino)methyl)(methyl)amino)acetic acid; (alpha-Methylguanido)acetate; (alpha-Methylguanido)acetic acid; Cosmocair C 100; Creatin; Creatine; Creatine hydrate; Kreatin; Krebiozon; Methylguanidoacetate; Methylguanidoacetic acid; N-(Aminoiminomethyl)-N-Methyl-Glycine; N-Methyl-N-guanylglycine; Phosphagen; [[Amino(imino)methyl](methyl)amino]acetate; [[Amino(imino)methyl](methyl)amino]acetic acid

# Chemical_IUPAC_Name:
2-(carbamimidoyl-methyl-amino)acetic acid

# Chemical_Formula:
C4H9N3O2

# Chemical_Structure:
tbl_chemical:::HMDB00064_ZOOM.png:::119283168559478961

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00064_THUMB.png:::119283168400619751

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Nitrogenous Compounds

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
carboxylic acid; guanidine

# Taxonomy_Biofunction:
Component of Arginine and proline metabolism; Component of Glycine, serine and threonine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
131.06949

# Molecular_Weight_Avg:
131.13316

# Smiles_String_isomeric:
CN(CC(O)=O)C(N)=N

# Smiles_String_canonical:
CN(CC(O)=O)C(N)=N

# KEGG_Compound_ID:
C00300

# BioCyc_ID:
CREATINE

# PubChem_CID:
586

# PubChem_SID:
10327145; 10527747; 148804; 15170675; 2549; 3139605; 3594; 4947662; 6436486; 74369; 7886773; 7986834; 8137931; 8143593; 8150697; 831847; 833800; 855190

# OMIM_ID:
123270; 123280; 123290; 123295; 123310; 123320; 300036; 300352; 601240; 601253; 602360; 607155

# Metagene_ID:
ARGININEMIA. HYPERARGININEMIA, ARGINASE DEFICIENCY: 60; CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY: 349; X-LINKED CREATINE-TRANSPORTER DEFECT: 488; L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY: 491

# BiGG_ID:
34543

# Wikipedia_ID:
Creatine

# METLIN_ID:
7

# Ref_ID:
12851769; 16855203; 16331129; 16416332; 11570870; 16581862; 10825659; 11375287; 11522277; 15627241; 6411064; 16509464; 9475367; 16287366; 15902992; 16260971; 15273072; 15513279; 15302082; 6321058

# ChEBI_ID:
16919

# CAS_Registry_Number:
57-00-1

# InChI:
InChI=1/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)

# Synthesis_Reference:
Preparation of guanido acids and guanido peptides.     Schutte, Ernst.    Z. physiol. Chem.  (1943),  279  52-9.

# Melting_Point:
303 oC

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
13.3 mg/mL at 18 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
4.11 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-0.2 [Predicted by PubChem via XLOGP]; -1.58 [Predicted by ALOGPS]; -3.72 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::1168583344.pdf:::182909226714936

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::1168583367.mol:::133089042063209

# SDF_File_[Text]:
tbl_chemical:::HMDB00064.sdf:::11928316802657124

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00064.pdb:::119283168258630298

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041003_P00_04_HW_1DP_PRESAT_expanded_2.gif:::114460741627180128

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041003_P00_04_HW_1DP_presat.zip:::1177710556532115118

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041003_P00_04_HW_1DP_Assigned.png:::114660033310350942

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041003_P00_04_HW_1DP_presat.png:::114859045562369883

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041003_P00_04_HW_1DP_presat.zip:::114859045562816114

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041003_P00_04_HW_2DHSQC_34.jpg:::114495623763365417

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041003_P00_04_HW_2DHSQC_34.zip:::114495623768418005

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041003_P00_04_HW_2DHSQC_34_Assigned.jpg:::114495623786767083

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Creatine.gif:::1132732104671269751

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00064_peaks.txt:::1156309522466219108

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Creatine_C.gif:::1132737672749595503

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00064_peaks.txt:::1156310712899922153

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00064L.png:::117555261948310027; Medium Energy:tbl_ms:::HMDB00064M.png:::117555267068559785; High Energy:tbl_ms:::HMDB00064H.png:::117555270924230576

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000078.png:::116890825998439987

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000078.txt:::116890826018731035

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria

# Tissue_Location:
Adipose Tissue; Bladder; Brain; Epidermis; Fibroblasts; Heart; Intestine; Kidney; Muscle; Myelin; Nerves; Neurons; Placenta; Platelet; Prostate; Skeletal Muscle; Skeletal Muscles; Spleen; Testes; Testis

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	113.0 (0.00-654.0)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	6321058
Blood	84.0 +/- 23.2	umol/L	Newborn:0-30_days_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 90. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	53.0 (17.0 - 82.0)	umol/L	Children:1-13_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 90. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	70.0	umol/L	Adult:>18_yrs_old	Both	Normal	6411064
Cerebrospinal_Fluid(CSF)	156.0 +/- 50.0	uM	Adult:>18_yrs_old	Both	Normal	HMP Experimental
Cerebrospinal_Fluid(CSF)	127.0 (108.0-146.0)	umol/L	Adult:>18_yrs_old	Both	Normal	15627241


# Concentration_[Abnormal]:
Urine	37.0 (0.0-197.0)	umol/mmol_creatinine	N/A	Both	Lung Cancer	
Cerebrospinal_Fluid(CSF)	166.0 (156.0-176.0)	umol/L	Adult:>18_yrs_old	Both	Bacterial meningitis	15627241


# Associated_Disorders:
 (Cachexia); Bacterial meningitis; Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency; Disc herniation; Glycine Amidinotransferase Deficiency; Lung Cancer; Myocardial Ischemia; Myopathy; Rhabdomyolysis; X-Linked Creatine-Transporter Defect

# Pathway_Names:
Not Available

# Pathway_Images:
Not Available

# KEGG_Images:
Not Available

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5993

# Metabolic_Enzyme_1_Name:
Creatine kinase, sarcomeric mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
S- MtCK; Mib-CK; Basic-type mitochondrial creatine kinase

# Metabolic_Enzyme_1_Gene_Name:
CKMT2

# Metabolic_Enzyme_1_Protein_Sequence:
>Creatine kinase, sarcomeric mitochondrial precursor
MASIFSKLLTGRNASLLFATMGTSVLTTGYLLNRQKVCAEVREQPRLFPPSADYPDLRKH
NNCMAECLTPAIYAKLRNKVTPNGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFA
DLFDPVIKLRHNGYDPRVMKHTTDLDASKITQGQFDEHYVLSSRVRTGRSIRGLSLPPAC
TRAERREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCAG
MARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQE
RGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKDPRFSKILENLRLQKRGTGGVD
TAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGKK

# Metabolic_Enzyme_1_Number_of_Residues:
419

# Metabolic_Enzyme_1_Molecular_Weight:
47505

# Metabolic_Enzyme_1_Theoretical_pI:
8.31

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa

# Metabolic_Enzyme_1_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_1_Reaction:
ATP + creatine = ADP + phosphocreatine

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00217:ATP-gua_Ptrans;
PF02807:ATP-gua_PtransN

# Metabolic_Enzyme_1_Signals:
1-27

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.7.3.2

# Metabolic_Enzyme_1_GenBank_ID_Protein:
338237

# Metabolic_Enzyme_1_SwissProt_ID:
KCRS_HUMAN (P17540)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
CKMT2

# Metabolic_Enzyme_1_Geneatlas_id:
CKMT2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:1996

# Metabolic_Enzyme_1_PDB_ID:
1CRK

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane; intermembrane side

# Metabolic_Enzyme_1_Gene_Sequence:
>1260 bp
ATGGCCAGTATCTTTTCTAAGTTGCTAACTGGCCGCAATGCTTCTCTGCTGTTTGCTACC
ATGGGCACCAGTGTCCTGACCACCGGGTACCTGCTGAACCGGCAGAAAGTGTGTGCCGAG
GTCCGGGAGCAGCCTAGGCTATTTCCTCCAAGCGCAGACTACCCAGACCTGCGCAAGCAC
AACAACTGCATGGCCGAGTGCCTCACCCCCGCCATTTATTCCAAGCTTCGCAACAAGGTG
ACACCCAACGGCTACACGCTGGACCAGTGCATCCAGACTGGAGTGGACAACCCTGGCCAC
CCCTTCATAAAGACTGTGGGCATGGTGGCTGGTGACGAGGAGTCCTATGAGGTGTTTGCT
GACCTTTTTGACCCCGTCATCAAACTAAGACACAACGGCTATGACCCCAGGGTGATGAAG
CACACAACGGATCTGGATGCATCAAAGATCACCCAAGGGCAGTTCGACGAGCATTACGTG
CTGTCTTCTCGGGTGCGCACTGGCCGCAGCATCCGTGGGCTGAGCCTGCCTCCAGCCTGC
ACCCGGGCCGAGCGAAGGGAGGTAGAGAACGTGGCCATCACTGCCCTGGAGGGCCTCAAG
GGGGACCTGGCTGGCCGCTACTACAAGCTGTCCGAGATGACGGAGCAGGACCAGCAGCGG
CTCATCGATGACCACTTTCTGTTTGATAAGCCAGTGTCCCCTTTATTAACATGTGCTGGG
ATGGCCCGTGACTGGCCAGATGCCAGGGGAATCTGGCATAATTATGATAAGACATTTCTC
ATCTGGATAAATGAGGAGGATCACACCAGGGTAATCTCAATGGAAAAAGGAGGCAATATG
AAACGAGTATTTGAGCGATTCTGTCGTGGACTAAAAGAAGTAGAACGGTTAATCCAAGAA
CGAGGCTGGGAGTTCATGTGGAATGAGCGCCTAGGATACATTTTGACCTGTCCTTCGAAC
CTTGGAACAGGACTACGAGCTGGTGTCCACGTTAGGATCCCAAAGCTCAGCAAGGACCCA
CGCTTTTCTAAGATCCTGGAAAACCTAAGACTCCAGAAGCGTGGCACAGGTGGTGTGGAC
ACTGCCGCGGTCGCAGATGTGTACGACATTTCCAACATAGATAGAATTGGTCGATCAGAG
GTTGAGCTTGTTCAGATAGTCATCGATGGAGTCAATTACCTGGTGGATTGTGAAAAGAAG
TTGGAGAGAGGCCAAGATATTAAGGTGCCACCCCCTCTGCCTCAGTTTGGCAAAAAGTAA


# Metabolic_Enzyme_1_GenBank_ID_Gene:
J05401

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_1_Locus:
5q13.3

# Metabolic_Enzyme_1_SNPs:
rs2270824; rs750728; rs545; rs3756636; rs2897390; rs871701; rs4704707; rs4704714; rs2277034; rs4704710; rs10073527; rs16878572; rs9293841; rs17294956; rs10514214; rs4704711; rs2277037; rs10041063; rs11950033; rs4704712; rs4704708; rs10942945; rs11953955; rs4704713; rs12659947; rs4704709; rs16878563; rs7728591; rs7728465; rs16876403; rs7720009; rs2277035; rs9799975; rs2277036; rs13184427; rs11749113; rs6877435; rs2270823; rs10514215; rs10036376; rs13159978; rs13165636; rs6899067; rs976741; rs1960671; rs6893467; rs4703828; rs4704717; rs6872183; rs10071174; rs12652649; rs13155580; rs4704716; rs10078279; rs7718501; rs13187211; rs6872504; rs3776980; rs1870061; rs4703827; rs15497; rs1063543; rs2085455; rs13179067; rs35646117; rs28482890; rs35579697; rs35823599; rs2077095; rs28690592; rs5869078; rs9799946; rs28650401; rs6888427; rs34940324; rs11739068; rs35452844; rs28417901; rs2085453; rs6888785; rs5869077; rs34443830; rs35813740; rs11299817; rs2085454; rs1138062; rs10624798; rs35548767; rs3083041; rs34755999; rs34239439; rs34825989; rs34330118; rs4704715; rs10525993; rs10527529; rs34750598; rs28360729; rs34054011; rs34345589; rs3839313; rs35486745; rs12518822; rs3830407; rs34584571; rs35220210; rs12518716; rs13170098; rs12523577; rs36227075; rs10514212; rs10514213; rs10514216; rs11950261; rs12657721; rs17294418; rs2168628; rs2897389; rs34378267; rs4485907; rs6879111; rs6897055; rs6898834; rs7725743

# Metabolic_Enzyme_1_General_References:
2324105; 2914937

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5994

# Metabolic_Enzyme_2_Name:
Creatine kinase B-type

# Metabolic_Enzyme_2_Synonyms:
Creatine kinase B chain; B-CK

# Metabolic_Enzyme_2_Gene_Name:
CKB

# Metabolic_Enzyme_2_Protein_Sequence:
>Creatine kinase Btype
MPFSNSHNALKLRFPAEDEFPDLSAHNNHMAKVLTPELYAELRAKSTPSGFTLDDVIQTG
VDNPGHPYIMTVGCVAGDEESYEVFKDLFDPIIEDRHGGYKPSDEHKTDLNPDNLQGGDD
LDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLAGRYYALKSMT
EAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWVNEEDHLRVISM
QKGGNMKEVFTRFCTGLTQIETLFKSKDYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLP
NLGKHEKFSEVLKRLRLQKRGTGGVDTAAVGGVFDVSNADRLGFSEVELVQMVVDGVKLL
IEMEQRLEQGQAIDDLMPAQK

# Metabolic_Enzyme_2_Number_of_Residues:
381

# Metabolic_Enzyme_2_Molecular_Weight:
42645

# Metabolic_Enzyme_2_Theoretical_pI:
5.30

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa

# Metabolic_Enzyme_2_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_2_Reaction:
ATP + creatine = ADP + phosphocreatine

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00217:ATP-gua_Ptrans;
PF02807:ATP-gua_PtransN

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.7.3.2

# Metabolic_Enzyme_2_GenBank_ID_Protein:
180572

# Metabolic_Enzyme_2_SwissProt_ID:
KCRB_HUMAN (P12277)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
CKB

# Metabolic_Enzyme_2_Geneatlas_id:
CKB

# Metabolic_Enzyme_2_hgnc_id:
HGNC:1991

# Metabolic_Enzyme_2_PDB_ID:
1G0W

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1146 bp
ATGCCCTTCTCCAACAGCCACAACGCACTGAAGCTGCGCTTCCCGGCCGAGGACGAGTTC
CCCGACCTGAGCGCCCACAACAACCACATGGCCAAGGTGCTGACCCCCGAGCTGTACGCG
GACGTGCGCGCCAAGAGCACGCCGAGCGGCTTCACGCTGGACGACGTCATCCAGACAGGC
GTGGACAACCCGGGCCACCCGTACATCATGACCGTGGGCTGCGTGGCGGGCGACGAGGAG
TCCTACGAAGTGTTCAAGGATCTCTTCGACCCCATCATCGAGGACCGGCACCGGCGCTAC
AAGCCCAGCGATGACGACAAGACCGACCTCAACCCCGACAACCTGCAGGGCGGCGACGAC
CTGGACCCCAACTACGTGCTGAGCTCGCGGGTGGCCACGGGCCGCAGCATCCGTGGCTTC
TGCCTCCCCCCGCACTGCAGCCGCGGGGAGCGCCGAGCCATCGAGAAGCTCGCGGTGGAA
GCCCTGTCCAGCCTGGACGGCGACCTGGCGGGCCGATACTACGCGCTCAAGAGCATGACG
GAGGCGGAGCAGCAGCAGCTCATCGACGACCACTTCCTCTTCGACAAGCCCGTGTCGCCC
CTGCTGCTGGCCTCGGGCATGGCCCGCGACTGGCCCGACGCCGCGCGTATCTGGCACAAT
GACAATAAGACCTTCCTGGTGTGGGTCAACGAGGAGGACCACCTGCGGGTCATCTCCATG
CAGAAGGGGGGCAACATGAAGGAGGTGTTCACCCGCTTCTGCACCGGCCTCACCCAGATT
GAAACTCTCTTCAAGTCTAAGGACTATGAGTTCATGTGGAACCCTCACCTGGGCTACATC
CTCACCTGCCCATCCAACCTGGGCACCGGGCTGCGGGCAGGTGTCGATATCAAGCTGCCC
AACCTGGGCAAGCATGAGAAGTTCTCGGAGGTGCTTAAGCGGCTGCGACTTCAGAAGCGA
GGCACAGGCGGTGTGGACACGGCTGCGGTGGGCGGGGTCTTCGACGTCTCCAACGCTGAC
CGCCTGGGCTTCTCAGAGGTGGAGCTGGTGCAGATGGTGGTGGACGGAGTGAAGCTGCTC
ATCGAGATGGAACAGCGGCTGGAGCAGGGCCAGGCCATCGACGACCTCATGCCTGCCCAG
AAATGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M16451

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_2_Locus:
14q32

# Metabolic_Enzyme_2_SNPs:
rs12505; rs1803283; rs1136165; rs2071408; rs8017780; rs10129401; rs34874824; rs2071407; rs34995931; rs2246490; rs911549; rs8009905; rs7158972; rs7159665; rs3759584; rs2765042; rs11848341; rs35586956; rs34244728; rs35273920; rs35919700; rs2756121; rs35358407; rs35683215; rs911548; rs2756120; rs36089168; rs35156510; rs1803284; rs2985905; rs11545352; rs13558; rs2984134; rs11545348; rs11545347; rs36002620; rs11545350; rs11545344; rs11545349; rs34509468; rs3208514; rs11545345; rs11545351; rs11545353; rs36002867; rs1064582; rs2985906; rs2984135; rs2984136; rs11353836; rs12588926; rs35700145; rs35104673; rs35028876; rs3759582; rs34471567; rs2765043; rs35182058; rs3834517; rs35430697; rs34356817; rs10133035; rs10135716; rs10142726; rs10150072; rs1022736; rs11622473; rs11624256; rs1467561; rs2021965; rs2756122; rs2756125; rs2756138; rs2765037; rs2765040; rs2765046; rs2765047; rs2765048; rs34372508; rs35063593; rs4287497; rs4906332; rs754288; rs8004501; rs8019578; rs911550

# Metabolic_Enzyme_2_General_References:
3034271; 3692484; 2883200; 2771648; 2828370; 8186255

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5995

# Metabolic_Enzyme_3_Name:
Creatine kinase, ubiquitous mitochondrial precursor

# Metabolic_Enzyme_3_Synonyms:
U- MtCK; Mia-CK; Acidic-type mitochondrial creatine kinase

# Metabolic_Enzyme_3_Gene_Name:
CKMT1A

# Metabolic_Enzyme_3_Protein_Sequence:
>Creatine kinase, ubiquitous mitochondrial precursor
MAGPFSRLLSARPGLRLLALAGAGSLAAGFLLRPEPVRAASERRRLYPPSAEYPDLRKHN
NCMASHLTPAVYARLCDKTTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFAD
LFDPVIQERHNGYDPRTMKHTTDLDASKIRSGYFDERYVLSSRVRTGRSIRGLSLPPACT
RAERREVERVVVDALSGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGM
ARDWPDARGIWHNNEKSFLIWVNEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQER
GWEFMWNERLGYILTCPSNLGTGLRAGVHIKLPLLSKDSRFPKILENLRLQKRGTGGVDT
AATGGVFDISNLDRLGKSEVELVQLVIDGVNYLIDCERRLERGQDIRIPTPVIHTKH

# Metabolic_Enzyme_3_Number_of_Residues:
417

# Metabolic_Enzyme_3_Molecular_Weight:
47037

# Metabolic_Enzyme_3_Theoretical_pI:
8.47

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa

# Metabolic_Enzyme_3_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_3_Reaction:
ATP + creatine = ADP + phosphocreatine

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00217:ATP-gua_Ptrans;
PF02807:ATP-gua_PtransN

# Metabolic_Enzyme_3_Signals:
1-29

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.7.3.2

# Metabolic_Enzyme_3_GenBank_ID_Protein:
180590

# Metabolic_Enzyme_3_SwissProt_ID:
KCRU_HUMAN (P12532)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
CKMT1A

# Metabolic_Enzyme_3_Geneatlas_id:
CKMT1A

# Metabolic_Enzyme_3_hgnc_id:
HGNC:31736

# Metabolic_Enzyme_3_PDB_ID:
1QK1

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane; intermembrane side

# Metabolic_Enzyme_3_Gene_Sequence:
>1254 bp
ATGGCTGGTCCCTTCTCCCGTCTGCTGTCCGCCCGCCCGGGACTCAGGCTCCTGGCTTTG
GCCGGAGCGGGGTCTCTAGCCGCTGGGTTTCTGCTCCGACCGGAACCTGTACGAGCTGCC
AGTGAACGACGGAGGCTGTATCCCCCGAGCGCTGAGTACCCAGACCTCCGAAAGCACAAC
AACTGCATGGCCAGTCACCTGACCCCAGCAGTCTATGCACGGCTCTGCGACAAGACCACA
CCCACTGGTTGGACGCTAGATCAGTGTATCCAGACTGGCGTGGACAACCCTGGCCACCCC
TTCATCAAGACTGTGGGCATGGTGGCTGGAGATGAGGAGACCTATGAGGTATTTGCTGAC
CTGTTTGACCCTGTGATCCAAGAGCGACACAATGGATATGACCCCCGGACAATGAAGCAC
ACCACGGATCTAGATGCCAGTAAAATCCGTTCTGGCTACTTTGATGAGAGGTATGTATTG
TCCTCTAGAGTCAGAACTGGCCGAAGCATCCGAGGACTCAGTCTGCCTCCAGCTTGCACT
CGAGCAGAGCGACGAGAGGTGGAACGTGTTGTGGTGGATGCACTGAGTGGCCTGAAGGGT
GACCTGGCTGGACGTTACTATAGGCTCAGTGAGATGACAGAGGCTGAACAGCAGCAGCTT
ATTGATGACCACTTTCTGTTTGATAAGCCTGTGTCCCCGTTGCTGACTGCAGCAGGAATG
GCTCGAGACTGGCCAGATGCTCGTGGAATTTGGCACAACAATGAGAAGAGCTTCCTGATC
TGGGTGAATGAGGAGGATCATACACGGGTGATCTCCATGGAGAAGGGTGGTAACATGAAG
AGAGTGTTTGAAAGATTCTGCCGAGGCCTCAAAGAGGTGGAGAGACTTATCCAAGAACGT
GGCTGGGAGTTCATGTGGAATGAGCGTTTGGGATACATCTTGACCTGTCCATCTAACCTG
GGCACTGGACTTCGGGCAGGAGTGCACATCAAACTGCCCCTGCTAAGCAAAGATAGCCGC
TTCCCAAAGATCCTGGAGAACCTAAGACTCCAAAAACGTGGTACTGGAGGAGTGGACACT
GCTGCTACAGGCGGTGTCTTTGATATTTCTAATTTGGACCGACTAGGCAAATCAGAGGTG
GAGCTGGTGCAACTGGTCATCGATGGAGTAAACTATTTGATTGATTGTGAACGGCGTCTG
GAGAGAGGCCAGGATATCCGCATCCCCACACCTGTCATCCACACCAAGCATTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
J04469

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_3_Locus:
15q15

# Metabolic_Enzyme_3_SNPs:
rs2412808; rs2259951; rs2614795; rs2412807; rs2259950; rs2411270; rs2411269; rs3866939; rs2411268; rs2467424; rs3866938; rs2467423; rs28433760; rs28578041; rs3809473; rs17795770; rs7175525

# Metabolic_Enzyme_3_General_References:
2914937

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5663

# Metabolic_Enzyme_4_Name:
Guanidinoacetate N-methyltransferase

# Metabolic_Enzyme_4_Synonyms:
Not Available

# Metabolic_Enzyme_4_Gene_Name:
GAMT

# Metabolic_Enzyme_4_Protein_Sequence:
>Guanidinoacetate Nmethyltransferase
MSAPSATPIFAPGENCSPAWGAAPAAYDAADTHLRILGKPVMERWETPYMHALAAAASSK
GGRVLEVGFGMAIAASKVQEAPIDEHWIIECNDGVFQRLRDWAPRQTHKVIPLKGLWEDV
APTLPDGHFDGILYDTYPLSEETWHTHQFNFIKNHAFRLLKPGGVLTYCNLTSWGELMKS
KYSDITIMFEETQVPALLEAGFRRENIRTEVMALVPPADCRYYAFPQMITPLVTKG

# Metabolic_Enzyme_4_Number_of_Residues:
236

# Metabolic_Enzyme_4_Molecular_Weight:
26318

# Metabolic_Enzyme_4_Theoretical_pI:
6.09

# Metabolic_Enzyme_4_GO_Classification:
Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine

# Metabolic_Enzyme_4_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_4_Reaction:
S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine

# Metabolic_Enzyme_4_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.1.1.2

# Metabolic_Enzyme_4_GenBank_ID_Protein:
1212946

# Metabolic_Enzyme_4_SwissProt_ID:
GAMT_HUMAN (Q14353)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
GAMT

# Metabolic_Enzyme_4_Geneatlas_id:
GAMT

# Metabolic_Enzyme_4_hgnc_id:
HGNC:4136

# Metabolic_Enzyme_4_PDB_ID:
1XCL

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>711 bp
ATGAGCGCCCCCAGCGCGACCCCCATCTTCGCGCCCGGCGAGAACTGCAGCCCCGCGTGG
GGGGCGGCGCCCGCGGCCTACGACGCAGCGGACACGCACCTGCGCATCCTGGGCAAGCCG
GTGATGGAGCGCTGGGAGACCCCCTATATGCACGCGCTGGCCGCCGCCGCCTCCTCCAAA
GGGGGCCGGGTCCTGGAGGTGGGCTTTGGCATGGCCATCGCAGCGTCAAAGGTGCAGGAG
GCGCCCATTGATGAGCATTGGATCATCGAGTGCAATGACGGCGTCTTCCAGCGGCTCCGG
GACTGGGCCCCACGGCAGACACACAAGGTCATCCCCTTGAAAGGCCTGTGGGAGGATGTG
GCACCCACCCTGCCTGACGGTCACTTTGATGGGATCCTGTACGACACGTACCCACTCTCG
GAGGAGACCTGGCACACACACCAGTTCAACTTCATCAAGAACCACGCCTTTCGCCTGCTG
AAGCCGGGGGGCGTCCTCACCTACTGCAACCTCACCTCCTGGGGGGAGCTGATGAAGTCC
AAGTACTCAGACATCACCATCATGTTTGAGGAGACGCAGGTGCCCGCGCTGCTGGAGGCC
GGCTTCCGGAGGGAGAACATCCGTACGGAGGTGATGGCGCTGGTCCCACCGGCCGACTGC
CGCTACTACGCCTTCCCACAGATGATCACGCCCCTGGTGACCAAAGGCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
Z49878

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_4_Locus:
19p13.3

# Metabolic_Enzyme_4_SNPs:
rs17851582; rs659455; rs659460; rs266806; rs266808; rs9973220; rs2074899; rs266807; rs3786974; rs266813; rs266815; rs3888624; rs36040336; rs266814; rs11551914; rs1050914; rs11551915; rs11670139; rs4316878; rs266809; rs576699; rs3760991; rs3760992; rs3888625; rs266811; rs266812; rs3837984; rs3760990; rs266810; rs35696696; rs1142530; rs11666067; rs11672484; rs2074895; rs2074896; rs2074897; rs2074898; rs2240605; rs265271; rs3786975; rs3786976; rs502121; rs5024535; rs5024536; rs5024537; rs619693; rs7254913; rs7256647; rs7258846; rs809359

# Metabolic_Enzyme_4_General_References:
8547310; 9325156

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5996

# Metabolic_Enzyme_5_Name:
Creatine kinase M-type

# Metabolic_Enzyme_5_Synonyms:
Creatine kinase M chain; M-CK

# Metabolic_Enzyme_5_Gene_Name:
CKM

# Metabolic_Enzyme_5_Protein_Sequence:
>Creatine kinase Mtype
MPFGNTHNKFKLNYKPEEEYPDLSKHNNHMAKVLTLELYKKLRDKETPSGFTVDDVIQTG
VDNPGHPFIMTVGCVAGDEESYEVFKELFDPIISDRHGGYKPTDKHKTDLNHENLKGGDD
LDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMT
EKEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISM
EKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNQHLGYVLTCPSNLGTGLRGGVHVKLA
HLSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVFDVSNADRLGSSEVEQVQLVVDGVKLM
VEMEKKLEKGQSIDDMIPAQK

# Metabolic_Enzyme_5_Number_of_Residues:
381

# Metabolic_Enzyme_5_Molecular_Weight:
43102

# Metabolic_Enzyme_5_Theoretical_pI:
7.28

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa

# Metabolic_Enzyme_5_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_5_Reaction:
ATP + creatine = ADP + phosphocreatine

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00217:ATP-gua_Ptrans;
PF02807:ATP-gua_PtransN

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.7.3.2

# Metabolic_Enzyme_5_GenBank_ID_Protein:
180576

# Metabolic_Enzyme_5_SwissProt_ID:
KCRM_HUMAN (P06732)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
CKM

# Metabolic_Enzyme_5_Geneatlas_id:
CKM

# Metabolic_Enzyme_5_hgnc_id:
HGNC:1994

# Metabolic_Enzyme_5_PDB_ID:
1I0E

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1146 bp
ATGCCATTCGGTAACACCCACAACAAGTTCAAGCTGAATTACAAGCCTGAGGAGGAGTAC
CCCGACCTCAGCAAACATAACAACCACATGGCCAAGGTACTGACCCTTGAACTCTACAAG
AAGCTGCGGGACAAGGAGATCCCATCTGGCTTCACTGTAGACGATGTCATCCAGACAGGA
GTGGACAACCCAGGTCACCCCTTCATCATGACCGTGGGCTGCGTGGCTGGTGATGAGGAG
TCCTACGAAGTTTTCAAGGAACTCTTTGACCCCATCATCTCGGATCGCCACGGGGGCTAC
AAACCCACTGACAAGCACAAGACTGACCTCAACCATGAAAACCTCAAGGGTGGAGACGAC
CTGGACCCCAACTACGTGCTCAGCAGCCCGGTCCGCACTGGCCGCAGCATCAAGGGCTAC
ACGTTGCCCCCACACTGCTCCCGTGGCGAGCGCCGGGCGGTGGAGAAGCTCTCTGTGGAA
GCTCTCAACAGCCTGACGGGCGAGTTCAAAGGGAAGTACTACCCTCTGAAGAGCATGACG
GAGAAGGAGCAGCAGCAGCTCATCGATGACCACTTCCAGTTCGACAAGCCCGTGTCCCCG
CTGCTGCTGGCCTCAGGCATGGCCCGCCACTGGCCCGACGCCCCTGGCATCTGGCACAAT
GACAACAAGAGCTTCCTGGTGTGGGTGAACGAGGAGGATCACCTCCGGGTCATCTCCATG
GAGAAGGGGGGCAACATGAAGGAGGTTTTCCGCCGCTTCTGCGTAGGGCTGCAGAAGATT
GAGGAGATCTTTAAGAAAGCTGGCCACCCCTTCATGTGGAACCAGCACCTGGGCTACGTG
CTCACCTGCCCATCCAACCTGGGCACTGGGCTGCGTGGAGGCGTGCATGTGAAGCTGGCG
CACCTGAGCAAGCACCCCAAGTTCGAGGAGATCCTCACCCGCCTGCGTCTGCAGAAGAGG
GGTACAGGTGCGGTGGACACAGCTGCCGTGGGCTCAGTATTTGACGTGTCCAACGCTGAT
CGGCTGGGCTCGTCCGAAGTAGAACAGGTGCAGCTGGTGGTGGATGGTGTGAAGCTCATG
GTGGAAATGGAGAAGAAGTTGGAGAAAGGCCAGTCCATCGACGACATGATCCCCGCCCAG
AAGTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M14780

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_5_Locus:
19q13.2-q13.3

# Metabolic_Enzyme_5_SNPs:
rs1133190; rs4884; rs17875616; rs344816; rs344818; rs6509208; rs17875629; rs10410448; rs344817; rs344819; rs12981681; rs17875646; rs17875590; rs344820; rs17875642; rs8188; rs17875645; rs17875644; rs9976; rs17875641; rs17875648; rs639783; rs10402747; rs11878918; rs344793; rs432979; rs7260463; rs12976956; rs7260359; rs8109616; rs2238685; rs2377326; rs364755; rs377993; rs4803813; rs12460022; rs10411862; rs12971433; rs635921; rs17875613; rs344794; rs17875626; rs635898; rs17875609; rs1967311; rs17875654; rs8104850; rs17875614; rs17875617; rs365065; rs12983935; rs7251748; rs12983944; rs11878815; rs10408267; rs12984728; rs17875652; rs17875622; rs17875618; rs12976243; rs17875621; rs8111989; rs7247937; rs11882479; rs344815; rs17875640; rs17875639; rs17875637; rs17875630; rs17875638; rs17850202; rs17357122; rs1803285; rs17875625; rs17875653; rs11559024; rs17875604; rs11559023; rs7245998; rs10679457; rs35663040; rs17875643; rs17875647; rs17875592; rs936734; rs17875591; rs17875628; rs35529544; rs17875596; rs12974541; rs35089528; rs35792454; rs3047558; rs17875655; rs17875624; rs17875650; rs12979234; rs13345562; rs11368156; rs4803811; rs17875649; rs34477933; rs34866922; rs34641274; rs7252388; rs35930252; rs344795; rs11880175; rs4389234; rs427868; rs34906823; rs560205; rs560058; rs35379717; rs17875602; rs7254199; rs17875620; rs17875606; rs12979226; rs34100970; rs34729831; rs17875601; rs1967310; rs11880179; rs4803812; rs28488794; rs17875631; rs17875588; rs1044098; rs11083769; rs11666893; rs11667235; rs11672894; rs11672923; rs123187; rs12609536; rs12971782; rs12972277; rs16979759; rs171100; rs173179; rs2306660; rs2377325; rs2395; rs344791; rs344797; rs344800; rs344802; rs344804; rs344805; rs344806; rs7253192; rs8106963

# Metabolic_Enzyme_5_General_References:
3778496; 2903158; 3031982; 1690725; 10089465

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5792

# Metabolic_Enzyme_6_Name:
L-lactate dehydrogenase C chain

# Metabolic_Enzyme_6_Synonyms:
LDH-C; LDH testis subunit; LDH-X

# Metabolic_Enzyme_6_Gene_Name:
LDHC

# Metabolic_Enzyme_6_Protein_Sequence:
>Llactate dehydrogenase C chain
MSTVKEQLIEKLIEDDENSQCKITIVGTGAVGMACAISILLKDLADELALVDVALDKLKG
EMMDLQHGSLFFSTSKITSGKDYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSI
IPAIVHYSPDCKILVVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGV
HPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLGTDSDKEHWKNIHKQVIQSAYE
IIKLKGYTSWAIGLSVMDLVGSILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGV
SDVVKINLNSEEEALFKKSAETLWNIQKDLIF

# Metabolic_Enzyme_6_Number_of_Residues:
332

# Metabolic_Enzyme_6_Molecular_Weight:
36312

# Metabolic_Enzyme_6_Theoretical_pI:
7.53

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  anaerobic glycolysis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_6_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_6_Specific_Function:
Possible role in sperm motility

# Metabolic_Enzyme_6_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00272  Cysteine metabolism;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_6_Reaction:
(S)-lactate + NAD+ = pyruvate + NADH + H+

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF02866:Ldh_1_C;
PF00056:Ldh_1_N

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.1.1.27

# Metabolic_Enzyme_6_GenBank_ID_Protein:
307120

# Metabolic_Enzyme_6_SwissProt_ID:
LDHC_HUMAN (P07864)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
LDHC

# Metabolic_Enzyme_6_Geneatlas_id:
LDHC

# Metabolic_Enzyme_6_hgnc_id:
HGNC:6544

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_6_Gene_Sequence:
>999 bp
ATGTCAACTGTCAAGGAGCAGCTAATTGAGAAGCTAATTGAGGATGATGAAAACTCCCAG
TGTAAAATTACTATTGTTGGAACTGGTGCCGTAGGCATGGCTTGTGCTATTAGTATCTTA
CTGAAGGATTTGGCTGATGAACTTGCCCTTGTTGATGTTGCATTGGACAAACTGAAGGGA
GAAATGATGGATCTTCAGCATGGCAGTCTTTTCTTTAGTACTTCAAAGGTTACTTCTGGA
AAAGATTACAGTGTATCTGCAAACTCCAGAATAGTTATTGTCACAGCAGGTGCAAGGCAG
CAGGAGGGAGAAACTCGCCTTGCCCTGGTCCAACGTAATGTGGCTATAATGAAAATAATC
ATTCCTGCCATAGTCCATTATAGTCCTGATTGTAAAATTCTTGTTGTTTCAAATCCAGTG
GATATTTTGACATATATAGTCTGGAAGATAAGTGGCTTACCTGTAACTCGTGTAATTGGA
AGTGGTTGTAATCTAGACTCTGCCCGTTTCCGTTACCTAATTGGAGAAAAGTTGGGTGTC
CACCCCACAAGCTGCCATGGTTGGATTATTGGAGAACATGGTGATTCTAGTGTGCCCTTA
TGGAGTGGGGTGAATGTTGCTGGTGTTGCTCTGAAGACTCTGGACCCTAAATTAGGAACG
GATTCAGATAAGGAACACTGGAAAAATATCCATAAACAAGTTATTCAAAGTGCCTATGAA
ATTATCAAGCTGAAGGGGTATACCTCTTGGGCTATTGGACTGTCTGTGATGGATCTGGTA
GGATCCATTTTGAAAAATCTTAGGAGAGTGCACCCAGTTTCCACCATGGTTAAGGGATTA
TATGGAATAAAAGAAGAACTCTTTCTCAGTATCCCTTGTGTCTTGGGGCGGAATGGTGTC
TCAGATGTTGTGAAAATTAACTTGAATTCTGAGGAGGAGGCCCTTTTCAAGAAGAGTGCA
GAAACACTTTGGAATATTCAAAAGGATCTAATATTTTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
J02938

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_6_Locus:
11p15.5-p15.3

# Metabolic_Enzyme_6_SNPs:
rs16935436; rs1881717; rs12293002; rs2037868; rs1908560; rs2056781; rs2896527; rs2403280; rs1406580; rs2658566; rs7111815; rs2643856; rs2721126; rs2658551; rs11024647; rs3740713; rs12270402; rs10832934; rs7938942; rs12289603; rs2658548; rs4757662; rs10766478; rs16935432; rs16935431; rs16935424; rs2403298; rs2698563; rs12416742; rs11606494; rs2056783; rs2698566; rs7110605; rs10766477; rs11024648; rs2698558; rs6486427; rs35593189; rs2056782; rs4757664; rs2643857; rs2698568; rs2658549; rs11024651; rs12282669; rs11024649; rs968895; rs1848049; rs2658553; rs12576249; rs4757663; rs11605386; rs3809096; rs3809098; rs4757660; rs7938267; rs3809097; rs7951953; rs4757656; rs1506520; rs4757655; rs11558332; rs11558333; rs2658565; rs3740714; rs10610261; rs12807225; rs11292121; rs2463909; rs35077834; rs4756943; rs11024652; rs11024657; rs35754271; rs35064545; rs11325380; rs34480310; rs33998563; rs2056784; rs2643871; rs34279411; rs36113234; rs1318593; rs7481716; rs2643855; rs2721120; rs11024653; rs35128109; rs4628652; rs12806009; rs11313322; rs184855; rs4990347; rs1908561; rs2643859; rs34485747; rs36038254; rs35126672; rs35017114; rs35689913; rs34109624; rs35720604; rs35770509; rs34907251; rs34630228; rs35915766; rs12803458; rs34176196; rs5790036; rs4990348; rs11024650; rs1506519; rs2698562; rs34844393; rs34305958; rs3074202; rs11024655; rs34903699; rs4990349; rs12801224; rs7112151; rs2698569; rs2698557; rs35478086; rs4990345; rs1908562; rs11308924; rs2658550; rs35313043; rs12795955; rs35861956; rs35617285; rs36043375; rs2721125; rs34960411; rs1848048; rs34287236; rs35857834; rs33993685; rs34546967; rs11024656; rs2254195; rs5790037; rs36045982; rs34500057; rs4990346; rs171495; rs11321502; rs34884188; rs35134819; rs2698561; rs35976847; rs187227; rs34511927; rs35749455; rs2721124; rs35284710; rs2643860; rs28729286; rs2643872; rs35299578; rs34684673; rs35515498; rs12799374; rs35192552; rs7115524; rs189660; rs2643858; rs7111938; rs34515949; rs4757659; rs4757661; rs4757658; rs4757657; rs10832932; rs11024643; rs11024645; rs11605559; rs12269752; rs16935411; rs16935413; rs1881716; rs2721121; rs34305721; rs34546419; rs35864573; rs3758680; rs3758681; rs3758682; rs3758683; rs3781641; rs4757653; rs6486425

# Metabolic_Enzyme_6_General_References:
2440048; 2930531

# Metabolic_Enzyme_6_References:
16140088

# Metabolic_Enzyme_7_ID:
5331

# Metabolic_Enzyme_7_Name:
Alkaline phosphatase, placental-like precursor

# Metabolic_Enzyme_7_Synonyms:
Alkaline phosphatase Nagao isozyme; Germ-cell alkaline phosphatase; GCAP; PLAP-like; ALP-1

# Metabolic_Enzyme_7_Gene_Name:
ALPPL2

# Metabolic_Enzyme_7_Protein_Sequence:
>Alkaline phosphatase, placentallike precursor
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLG
DGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLC
GVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDY
SQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRD
STLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERA
GQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL
KDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHV
MAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP

# Metabolic_Enzyme_7_Number_of_Residues:
532

# Metabolic_Enzyme_7_Molecular_Weight:
57378

# Metabolic_Enzyme_7_Theoretical_pI:
6.31

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
A phosphate monoester + H(2)O = an alcohol + phosphate

# Metabolic_Enzyme_7_Pathway:
map00361  gamma-Hexachlorocyclohexane degradation;
 map00790  Folate biosynthesis

# Metabolic_Enzyme_7_Reaction:
A phosphate monoester + H2O = an alcohol + phosphate

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00245:Alk_phosphatase

# Metabolic_Enzyme_7_Signals:
1-19

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.1.3.1

# Metabolic_Enzyme_7_GenBank_ID_Protein:
178428

# Metabolic_Enzyme_7_SwissProt_ID:
PPBN_HUMAN (P10696)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
ALPPL2

# Metabolic_Enzyme_7_Geneatlas_id:
ALPPL2

# Metabolic_Enzyme_7_hgnc_id:
HGNC:441

# Metabolic_Enzyme_7_PDB_ID:
1EW2

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Metabolic_Enzyme_7_Gene_Sequence:
>1599 bp
ATGCAGGGGCCCTGGGTGCTGCTCCTGCTGGGCCTGAGGCTACAGCTCTCCCTGGGCATC
ATCCCAGTTGAGGAGGAGAACCCGGACTTCTGGAACCGCCAGGCAGCCGAGGCCCTGGGT
GCCGCCAAGAAGCTGCAGCCTGCACAGACAGCCGCCAAGAACCTCATCATGTTCCTGGGT
GACGGGATGGGGGTGTCTACGGTGACAGCTGCCAGGATCCTAAAAGGGCAGAAGAAGGAC
AAACTGGGGCCTGAGACCTTCCTGGCCATGGACCGCTTCCCGTACGTGGCTCTGTCCAAG
ACATACAGTGTAGACAAGCATGTGCCAGACAGTGGAGCCACAGCCACGGCCTACCTGTGC
GGGGTCAAGGGCAACTTCCAGACCATTGGCTTGAGTGCAGCCGCCCGCTTTAACCAGTGC
AACACGACACGCGGCAACGAGGTCATCTCCGTGGTGAATCGGGCCAAGAAAGCAGGAAAG
TCAGTGGGAGTGGTAACCACCACACGGGTGCAGCATGCCTCGCCAGCCGGCACCTACGCC
CACACGGTGAACCGCAACTGGTACTCGGATGCCGACGTGCCTGCCTCGGCCCGCCAGGAG
GGGTGCCAGGACATCGCCACGCAGCTCATCTCCAACATGGACATTGATGTGATCCTAGGT
GGAGGCCGAAAGTACATGTTTCCCATGGGGACCCCAGACCCTGAGTACCCAGATGACTAC
AGCCAAGGTGGGACCAGGCTGGACGGGAAGAATCTGGTGCAGGAATGGCTGGCGAAGCAC
CAGGGTGCCCGGTACGTGTGGAACCGCACTGAGCTCCTGCAGGCTTCCCTGGACCCGTCT
GTGACCCATCTCATGGGTCTCTTTGAGCCTGGAGACATGAAATACGAGATCCACCGAGAC
TCCACACTGGACCCCTCCCTGATGGAGATGACAGAGGCTGCCCTGCTCCTGCTGAGCAGG
AACCCCCGCGGCTTCTTCCTCTTCGTGGAGGGTGGTCGCATCGACCATGGTCATCATGAA
AGCAGGGCTTACCGGGCACTGACTGAGACGATCATGTTCGACGACGCCATTGAGAGGGCG
GGCCAGCTCACCAGCGAGGAGGACACGCTGAGCCTCGTCACTGCCGACCACTCCCACGTC
TTCTCCTTCGGAGGCTACCCCCTGCGAGGGAGCTCCATCTTCGGGCTGGCCCCTGGCAAG
GCCCGGGACAGGAAGGCCTACACGGTCCTCCTATACGGAAACGGTCCAGGCTATGTGCTC
AAGGACGGCGCCCGGCCGGATGTTACGGAGAGCGAGAGCGGGAGCCCCGAGTATCGGCAG
CAGTCAGCAGTGCCCCTGGACGGAGAGACCCACGCAGGCGAGGACGTGGCGGTGTTCGCG
CGCGGCCCGCAGGCGCACCTGGTTCACGGCGTGCAGGAGCAGACCTTCATAGCGCACGTC
ATGGCCTTCGCCGCCTGCCTGGAGCCCTACACCGCCTGCGACCTGGCGCCCCCCGCCGGC
ACCACCGACGCCGCGCACCCGGGGCCGTCCGTGGTCCCCGCGTTGCTTCCTCTGCTGGCA
GGGACCTTGCTGCTGCTGGGGACGGCCACTGCTCCCTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
J03252

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_7_Locus:
2q37

# Metabolic_Enzyme_7_SNPs:
rs1048983; rs1048999; rs17416141; rs2090543; rs1048997; rs1009934; rs2678519; rs2697781; rs3828248; rs3828254; rs2697767; rs3828249; rs2697768; rs1048995; rs16836187; rs3116148; rs1130334; rs41265119; rs41265117; rs3111340; rs41265115; rs1049002; rs1049001; rs3189080; rs3924351; rs1049003; rs1130348; rs1130351; rs3924352; rs3189077; rs6728119; rs2091555; rs2945420; rs2678518; rs41265113; rs3111339; rs3833560; rs2678517; rs2945421; rs41265111; rs2091556; rs3830644; rs3828251; rs3828253; rs2697769; rs11363206; rs3828250; rs3828252; rs11678251; rs1001868; rs10195918; rs13002718; rs13003189; rs13412526; rs1878691; rs2082841; rs2082842; rs2139026; rs2139027; rs2573208; rs2573209; rs2697766; rs2697790; rs2697791; rs2697792; rs2697793; rs2741321; rs2853380; rs732581; rs744873; rs744874; rs790050; rs790051

# Metabolic_Enzyme_7_General_References:
2834730; 2745460; 2297757; 2162249; 3387245

# Metabolic_Enzyme_7_References:
16644880; 16931083

# Metabolic_Enzyme_8_ID:
5515

# Metabolic_Enzyme_8_Name:
Aspartate aminotransferase, cytoplasmic

# Metabolic_Enzyme_8_Synonyms:
Transaminase A; Glutamate oxaloacetate transaminase 1

# Metabolic_Enzyme_8_Gene_Name:
GOT1

# Metabolic_Enzyme_8_Protein_Sequence:
>Aspartate aminotransferase, cytoplasmic
MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQK
IANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFL
ARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLEN
APEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWA
IRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPP
AQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGM
FSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ

# Metabolic_Enzyme_8_Number_of_Residues:
413

# Metabolic_Enzyme_8_Molecular_Weight:
46248

# Metabolic_Enzyme_8_Theoretical_pI:
7.01

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  transaminase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_8_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00272  Cysteine metabolism;
 map00330  Arginine and proline metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00401  Novobiocin biosynthesis;
 map00710  Carbon fixation;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_8_Reaction:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.6.1.1

# Metabolic_Enzyme_8_GenBank_ID_Protein:
179067

# Metabolic_Enzyme_8_SwissProt_ID:
AATC_HUMAN (P17174)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
GOT1

# Metabolic_Enzyme_8_Geneatlas_id:
GOT1

# Metabolic_Enzyme_8_hgnc_id:
HGNC:4432

# Metabolic_Enzyme_8_PDB_ID:
1AJS

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_8_Gene_Sequence:
>1242 bp
ATGGCACCTCCGTCAGTCTTTGCCGAGGTTCCGCAGGCCCAGCCTGTCCTGGTCTTCAAG
CTCACTGCCGACTTCAGGGAGGATCCGGACCCCCGCAAGGTCAACCTGGGAGTGGGAGCA
TATCGCACGGATGACTGCCATCCCTGGGTTTTGCCAGTAGTGAAGAAAGTGGAGCAGAAG
ATTGCTAATGACAATAGCCTAAATCACGAGTATCTGCCAATCCTGGGCCTGGCTGAGTTC
CGGAGCTGTGCTTCTCGTCTTGCCCTTGGGGATGACAGCCCAGCACTCAAGGAGAAGCGG
GTAGGAGGTGTGCAATCTTTGGGGGGAACAGGTGCACTTCGAATTGGAGCTGATTTCTTA
GCGCGTTGGTACAATGGAACAAACAACAAGAACACACCTGTCTATGTGTCCTCACCAACC
TGGGAGAATCACAATGCTGTGTTTTCCGCTGCTGGTTTTAAAGACATTCGGTCCTATCGC
TACTGGGATGCAGAGAAGAGAGGATTGGACCTCCAGGGCTTCCTGAATGATCTGGAGAAT
GCTCCTGAGTTCTCCATTGTTGTCCTCCACGCCTGTGCACACAACCCAACTGGGATTGAC
CCAACTCCGGAGCAGTGGAAGCAGATTGCTTCTGTCATGAAGCACCGGTTTCTGTTCCCC
TTCTTTGACTCAGCCTATCAGGGCTTCGCATCTGGAAACCTGGAGAGAGATGCCTGGGCC
ATTCGCTATTTTGTGTCTGAAGGCTTCGAGTTCTTCTGTGCCCAGTCCTTCTCCAAGAAC
TTCGGGCTCTACAATGAGAGAGTCGGGAATCTGACTGTGGTTGGAAAAGAACCTGAGAGC
ATCCTGCAAGTCCTTTCCCAGATGGAGAAGATCGTGCGGATTACTTGGTCCAATCCCCCC
GCCCAGGGAGCACGAATTGTGGCCAGCACCCTCTCTAACCCTGAGCTCTTTGAGGAATGG
ACAGGTAATGTGAAGACAATGGCTGACCGGATTCTGACCATGAGATCTGAACTCAGGGCA
CGACTAGAAGCCCTCAAAACCCCTGGGACCTGGAACCACATCACTGATCAAATTGGCATG
TTCAGCTTCACTGGGTTGAACCCCAAGCAGGTTGAGTATCTGGTCAATGAAAAGCACATC
TACCTGCTGCCAAGTGGTCGAATCAACGTGAGTGGCTTAACCACCAAAAATCTAGATTAC
GTGGCCACCTCCATCCATGAAGCAGTCACCAAAATCCAGTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
M37400

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_8_Locus:
10q24.1-q25.1

# Metabolic_Enzyme_8_SNPs:
rs2234971; rs2641; rs11867; rs1126878; rs11190083; rs2862611; rs4328160; rs4919310; rs11813054; rs3793935; rs4919308; rs17111658; rs3750897; rs2275952; rs7906501; rs7918062; rs7067702; rs9971275; rs9971274; rs11190087; rs11594790; rs12571181; rs12249347; rs10883343; rs11819158; rs4353208; rs3763793; rs11190088; rs17569447; rs3793933; rs7921465; rs12253915; rs3793934; rs2494651; rs10883341; rs2862612; rs2490280; rs12768505; rs17111665; rs2862613; rs17569578; rs4567385; rs11815136; rs10883342; rs10748775; rs4919309; rs17491012; rs12253861; rs11190081; rs2862614; rs12217584; rs11815637; rs12766044; rs17111645; rs17111694; rs4919311; rs12411568; rs11557841; rs4564264; rs41290500; rs11557840; rs1126927; rs11190082; rs2642; rs1802509; rs1802508; rs41290498; rs34854950; rs12777843; rs35687189; rs11394746; rs34971146; rs34646712; rs35478605; rs34582301; rs3045656; rs12252840; rs35736782; rs11378738; rs7918037; rs41400447; rs7896693; rs5787336; rs9731375; rs35003844; rs11456562; rs11313874; rs12358477; rs10668892; rs12241455; rs41436049; rs5787337; rs9971276; rs35500142; rs35096443; rs11456561; rs2902275; rs7899976; rs13377085; rs12777646; rs10629267; rs12414885; rs35193236; rs11325628; rs12777641; rs34254460; rs1892505; rs12776735; rs12776369; rs4917866; rs12775973; rs11816599; rs6584274; rs33928164; rs10786543; rs7917808; rs11429814; rs35546038; rs10716499; rs35665184; rs11190090; rs34122561; rs2234894; rs10748774; rs10786545; rs11190080; rs11190094; rs1132364; rs11592057; rs11598504; rs17111699; rs17490682; rs2298315; rs2298316; rs2490281; rs2490283; rs2494652; rs2494653; rs2494654; rs2862610; rs34183428; rs3750896; rs3793931; rs3793932; rs4345898; rs4917862; rs4917864; rs4919307; rs7099391; rs7914408; rs7920356

# Metabolic_Enzyme_8_General_References:
1974457; 2241899

# Metabolic_Enzyme_8_References:
16303703; 16492437; 16931083

# Metabolic_Enzyme_9_ID:
6131

# Metabolic_Enzyme_9_Name:
Alanine aminotransferase 1

# Metabolic_Enzyme_9_Synonyms:
ALT1; Glutamic--pyruvic transaminase 1; GPT 1; Glutamic--alanine transaminase 1

# Metabolic_Enzyme_9_Gene_Name:
GPT

# Metabolic_Enzyme_9_Protein_Sequence:
>Alanine aminotransferase 1
MASSTGDRSQAVRHGLRAKVLTLDGMNPRVRRVEYAVRGPIVQRALELEQELRQGVKKPF
TEVIRANIGD
AQAMGQRPITFLRQVLALCVNPDLLSSPNFPDDAKKRAERILQACGGHS
LGAYSVSSGIQLIREDVARYI
ERRDGGIPADPNNVFLSTGASDAIVTVLKLLVAGEGHT
RTGVLIPIPQYPLYSATLAELGAVQVDYYLDE
ERAWALDVAELHRALGQARDHCRPRAL
CVINPGNPTGQVQTRECIEAVIRFAFEERLFLLADEVYQDNVY
AAGSQFHSFKKVLMEM
GPPYAGQQELASFHSTSKGYMGECGFRGGYVEVVNMDAAVQQQMLKLMSVRLCP
PVPGQ
ALLDLVVSPPAPTDPSFAQFQAEKQAVLAELAAKAKLTEQVFNEAPGISCNPVQGAMYSF
PRVQL
PPRAVERAQELGLAPDMFFCLRLLEETGICVVPGSGFGQREGTYHFRMTILPPL
EKLRLLLEKLSRFHAK
FTLEYS

# Metabolic_Enzyme_9_Number_of_Residues:
496

# Metabolic_Enzyme_9_Molecular_Weight:
54638

# Metabolic_Enzyme_9_Theoretical_pI:
7.20

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-sulfur lyase activity
Function:  1-aminocyclopropane-1-carboxylate synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles

# Metabolic_Enzyme_9_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00710  Carbon fixation

# Metabolic_Enzyme_9_Reaction:
L-alanine + 2-oxoglutarate = pyruvate + L-glutamate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.6.1.2

# Metabolic_Enzyme_9_GenBank_ID_Protein:
1763096

# Metabolic_Enzyme_9_SwissProt_ID:
ALAT1_HUMAN (P24298)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
GPT

# Metabolic_Enzyme_9_Geneatlas_id:
GPT

# Metabolic_Enzyme_9_hgnc_id:
HGNC:4552

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_9_Gene_Sequence:
>1491 bp

ATGGCCTCGAGCACAGGTGACCGGAGCCAGGCGGTGAGGCATGGACTGAGGGCGAAGGT
GCTGACGCTGG
ACGGCATGAACCCGCGTGTGCGGAGAGTGGAGTACGCAGTGCGTGGCC
CCATAGTGCAGCGAGCCTTGGA
GCTGGAGCAGGAGCTGCGCCAGGGTGTGAAGAAGCCT
TTCACCGAGGTCATCCGTGCCAACATCGGGGAC
GCACAGGCTATGGGGCAGAGGCCCAT
CACCTTCCTGCGCCAGGTCTTGGCCCTCTGTGTTAACCCTGATC
TTCTGAGCAGCCCCA
ACTTCCCTGACGATGCCAAGAAAAGGGCGGAGCGCATCTTGCAGGCGTGTGGGGG
CCAC
AGTCTGGGGGCCTACAGCGTCAGCTCCGGCATCCAGCTGATCCGGGAGGACGTGGCGCGG
TACATT
GAGAGGCGTGACGGAGGCATCCCTGCGGACCCCAACAACGTCTTCCTGTCCAC
AGGGGCCAGCGATGCCA
TCGTGACGGTGCTGAAGCTGCTGGTGGCCGGCGAGGGCCACA
CACGCACGGGTGTGCTCATCCCCATCCC
CCAGTACCCACTCTACTCGGCCACGCTGGCA
GAGCTGGGCGCAGTGCAGGTGGATTACTACCTGGACGAG
GAGCGTGCCTGGGCGCTGGA
CGTGGCCGAGCTTCACCGTGCACTGGGCCAGGCGCGTGACCACTGCCGCC
CTCGTGCGC
TCTGTGTCATCAACCCTGGCAACCCCACCGGGCAGGTGCAGACCCGCGAGTGCATCGAGG
C
CGTGATCCGCTTCGCCTTCGAAGAGCGGCTCTTTCTGCTGGCGGACGAGGTGTACCAG
GACAACGTGTAC
GCCGCGGGTTCGCAGTTCCACTCATTCAAGAAGGTGCTCATGGAGAT
GGGGCCGCCCTACGCCGGGCAGC
AGGAGCTTGCCTCCTTCCACTCCACCTCCAAGGGCT
ACATGGGCGAGTGCGGGTTCCGCGGCGGCTATGT
GGAGGTGGTGAACATGGACGCTGCA
GTGCAGCAGCAGATGCTGAAGCTGATGAGTGTGCGGCTGTGCCCG
CCGGTGCCAGGACA
GGCCCTGCTGGACCTGGTGGTCAGCCCGCCCGCGCCCACCGACCCCTCCTTTGCGC
AGT
TCCAGGCTGAGAAGCAGGCAGTGCTGGCAGAGCTGGCGGCCAAGGCCAAGCTCACCGAGC
AGGTCTT
CAATGAGGCTCCTGGCATCAGCTGCAACCCAGTGCAGGGCGCCATGTACTCC
TTCCCGCGCGTGCAGCTG
CCCCCGCGGGCGGTGGAGCGCGCTCAGGAGCTGGGCCTGGC
CCCCGATATGTTCTTCTGCCTGCGCCTCC
TGGAGGAGACCGGCATCTGCGTGGTGCCAG
GGAGCGGCTTTGGGCAGCGGGAAGGCACCTACCACTTCCG
GATGACCATTCTGCCCCCC
TTGGAGAAACTGCGGCTGCTGCTGGAGAAGCTGAGCAGGTTCCATGCCAAG
TTCACCCT
CGAGTACTCCTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
U70732

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_9_Locus:
8q24.3

# Metabolic_Enzyme_9_SNPs:
Not Available

# Metabolic_Enzyme_9_General_References:
9119391; 1931970; 11863375

# Metabolic_Enzyme_9_References:
16201899; 16303703; 16519608; 16931083

# Metabolic_Enzyme_10_ID:
7885

# Metabolic_Enzyme_10_Name:
Gamma-glutamyltranspeptidase 1 precursor

# Metabolic_Enzyme_10_Synonyms:
Gamma- glutamyltransferase 1; GGT 1; CD224 antigen[Contains: Gamma- glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain]

# Metabolic_Enzyme_10_Gene_Name:
GGT1

# Metabolic_Enzyme_10_Protein_Sequence:
>Gammaglutamyltranspeptidase 1 precursor
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRD
GGSAVDAAIA
ALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMF
NSSEQSQKGGLSVAVPGEIRG
YELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAAL
ENKRTVIEQQPVLCEVFCRDRKVLREGERLTL
PQLADTYETLAIEGAQAFYNGSLTAQI
VKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAP
LSGPVLALILNILKGY
NFSRESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFF
AAQLR
AQISDDTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGI
LFNNE
MDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGG
TQITTATALAIIYNLW
FGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHH
TQIASTFIAVVQAIVRTAGGWAAASDS
RKGGEPAGY

# Metabolic_Enzyme_10_Number_of_Residues:
569

# Metabolic_Enzyme_10_Molecular_Weight:
61411

# Metabolic_Enzyme_10_Theoretical_pI:
7.14

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring amino-acyl groups
Function:  gamma-glutamyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive

# Metabolic_Enzyme_10_Pathway:
map00430  Taurine and hypotaurine metabolism;
 map00450  Selenoamino acid metabolism;
 map00460  Cyanoamino acid metabolism;
 map00480  Glutathione metabolism;
 map00590  Prostaglandin and leukotriene metabolism

# Metabolic_Enzyme_10_Reaction:
(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF01019:G_glu_transpept

# Metabolic_Enzyme_10_Signals:
1-30

# Metabolic_Enzyme_10_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.3.2.2

# Metabolic_Enzyme_10_GenBank_ID_Protein:
183138

# Metabolic_Enzyme_10_SwissProt_ID:
GGT1_HUMAN (P19440)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
GGT1

# Metabolic_Enzyme_10_Geneatlas_id:
GGT1

# Metabolic_Enzyme_10_hgnc_id:
HGNC:4250

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_10_Gene_Sequence:
>1710 bp

ATGAAGAAGAAGTTAGTGGTGCTGGGCCTGCTGGCCGTGGTCCTGGTGCTGGTCATTGT
CGGCCTCTGTC
TCTGGCTGCCCTCAGCCTCCAAGGAACCTGACAACCATGTGTACACCA
GGGCTGCCGTGGCCGCGGATGC
CAAGCAGTGCTCGAAGATTGGGAGGGATGCACTGCGG
GACGGTGGCTCTGCGGTGGATGCAGCCATTGCA
GCCCTGTTGTGTGTGGGGCTCATGAA
TGCCCACAGCATGGGCATCGGGGGTGGCCTCTTCCTCACCATCT
ACAACAGCACCACAC
GAAAAGCTGAGGTCATCAACGCCCGCGAGGTGGCCCCCAGGCTGGCCTTTGCCAC
CATG
TTCAACAGCTCGGAGCAGTCCCAGAAGGGGGGGCTGTCGGTGGCGGTGCCTGGGGAGATC
CGAGGC
TATGAGCTGGCACACCAGCGGCATGGGCGGCTGCCCTGGGCTCGCCTCTTCCA
GCCCAGCATCCAGCTGG
CCCGCCAGGGCTTCCCCGTGGGCAAGGGCTTGGCGGCAGCCC
TGGAAAACAAGCGGACCGTCATCGAGCA
GCAGCCTGTCTTGTGTGAGGTGTTCTGCCGG
GATAGAAAGGTGCTTCGGGAGGGGGAGAGACTGACCCTG
CCGCAGCTGGCTGACACCTA
CGAGACGCTGGCCATCGAGGGTGCCCAGGCCTTCTACAACGGCAGCCTCA
CGGCCCAGA
TTGTGAAGGACATCCAGGCGGCCGGGGGCATTGTGACAGCTGAGGACCTGAACAACTACC
G
TGCTGAGCTGATCGAGCACCCGCTGAACATCAGCCTGGGAGACGCGGTGCTGTACATG
CCCAGTGCGCCG
CTCAGCGGGCCCGTGCTGGCCCTCATCCTCAACATCCTCAAAGGGTA
CAACTTCTCCCGGGAGAGCGTGG
AGAGCCCCGAGCAGAAGGGCCTGACGTACCACCGCA
TCGTAGAGGCTTTCCGGTTTGCCTACGCCAAGAG
GACCCTGCTTGGGGACCCCAAGTTT
GTGGATGTGACTGAGGTGGTCCGCAACATGACCTCCGAGTTCTTC
GCTGCCCAGCTCCG
GGCCCAGATCTCTGACGACACCACTCACCCGATCTCCTACTACAAGCCCGAGTTCT
ACA
CGCCGGATGACGGGGGCACTGCTCACCTGTCTGTCGTCGCAGAGGACGGCAGTGCTGTGT
CCGCCAC
CAGCACCATCAACCTCTACTTTGGCTCCAAGGTCCGCTCCCCGGTCAGCGGG
ATCCTGTTCAATAATGAA
ATGGACGACTTCAGCTCTCCCAGCATCACCAACGAGTTTGG
GGTACCCCCCTCACCTGCCAATTTCATCC
AGCCAGGGAAGCAGCCGCTCTCGTCCATGT
GCCCGACGATCATGGTGGGCCAGGACGGCCAGGTCCGGAT
GGTGGTGGGAGCTGCTGGG
GGCACACAGATCACCACGGCCACTGCACTGGCCATCATCTACAACCTCTGG
TTCGGCTA
TGACGTGAAGCGGGCCGTGGAGGAGCCCCGGCTGCACAACCAGCTTCTGCCCAACGTCAC
GA
CAGTGGAGAGAAACATTGACCAGGCAGTGACTGCAGCCCTGGAGACCCGGCACCATC
ACACCCAGATCGC
GTCCACCTTCATCGCTGTGGTGCAAGCCATCGTCCGCACGGCTGGT
GGCTGGGCAGCTGCCTCGGACTCC
AGGAAAGGCGGGGAGCCTGCCGGCTACTGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
J04131

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_10_Locus:
22q11.23

# Metabolic_Enzyme_10_SNPs:
rs2330837; rs3895576; rs2330838; rs2017869; rs2330795; rs2073398; rs9624507; rs2006092; rs6519520; rs5751901; rs6519519; rs7284489; rs3788375; rs7292010; rs5760495; rs4049889; rs2006094; rs5760494; rs2001180; rs6004192; rs5751905; rs5760493; rs2006227; rs9624506; rs2005589; rs4822516; rs5751904; rs2073397; rs5760492; rs2076999; rs3859862; rs2010657; rs2003757; rs16990490; rs8138050; rs4049918; rs9608300; rs2017188; rs1807629; rs2330797; rs4822517; rs6004195; rs7286626; rs3747117; rs5760491; rs2330805; rs9624510; rs743371; rs3876104; rs4820600; rs5751902; rs5760490; rs6004193; rs6004194; rs8135987; rs8139070; rs5751909; rs5751910; rs9306396; rs9612676; rs5760505; rs2330848; rs5760499; rs5760497; rs5760504; rs4049843; rs9680722; rs2330841; rs524033; rs11913233; rs9680724; rs4049855; rs380131; rs3934421; rs4822523; rs5760500; rs6004203; rs3901297; rs5760498; rs391837; rs5751908; rs9680612; rs3895577; rs4822520; rs4049869; rs3895575; rs7511507; rs7511598; rs389004; rs2236626; rs7285339; rs2330842; rs4049882; rs4049829; rs28621555; rs2330836; rs3966247; rs12159765; rs4049897; rs4049881; rs9612682; rs2330843; rs4049844; rs4049883; rs2330844; rs5751900; rs2330830; rs12169166; rs4049900; rs2330818; rs2330826; rs9624503; rs3966256; rs9612663; rs3966255; rs3895580; rs4049911; rs2877222; rs2330801; rs3033885; rs9624509; rs6004196; rs4049914; rs2330835; rs1832359; rs28509371; rs4049896; rs2298391; rs2330825; rs9624505; rs2877224; rs4049885; rs2330811; rs4049917; rs2330806; rs3876101; rs3887791; rs12484586; rs4049890; rs8139074; rs3895578; rs28550867; rs4049905; rs4049925; rs3966259; rs673673; rs753462; rs4049899; rs2330813; rs8138031; rs4049895; rs28605797; rs3966263; rs3876105; rs9612666; rs2330808; rs2330832; rs2076800; rs13057657; rs3033738; rs3966257; rs2330803; rs2330815; rs4049912; rs3033744; rs2330810; rs2330800; rs3895574; rs6004191; rs8137090; rs2330807; rs2330834; rs4049913; rs28449741; rs2330827; rs3966260; rs9624504; rs2330817; rs9612671; rs4049903; rs2877221; rs5751903; rs2330824; rs2079567; rs2330796; rs4049898; rs11913684; rs2877225; rs2330831; rs4049891; rs4049915; rs2330812; rs4049910; rs4049916; rs4049908; rs12106564; rs3876100; rs3859863; rs3032936; rs9624508; rs4049901; rs12163146; rs4049924; rs4049906; rs2330819; rs9612664; rs3788376; rs3895579; rs2330822; rs2330804; rs2330823; rs2077120; rs2089350; rs2330814; rs2006093; rs4049904; rs9608301; rs3865759; rs2330799; rs3966258; rs28566494; rs2330820; rs3876103; rs2330802; rs4049926; rs3894886; rs3966262; rs2079568; rs2330816; rs2330809; rs2330798; rs2877223; rs4049902; rs8139073; rs4049865; rs4049850; rs4049857; rs2877228; rs28663139; rs4049837; rs4049873; rs4049867; rs4049860; rs28545702; rs34659550; rs3865654; rs4049863; rs28377326; rs3865651; rs4535160; rs4049839; rs11913428; rs2096530; rs28366457; rs4049828; rs3865649; rs9608303; rs4049861; rs6004202; rs2330853; rs6004200; rs4049833; rs10602389; rs9624512; rs4049875; rs2330849; rs3865659; rs3966245; rs2330852; rs12167273; rs4049847; rs2096529; rs4049868; rs7287997; rs4049880; rs4049835; rs3865653; rs11703306; rs4049878; rs2330846; rs3865657; rs35411004; rs2330850; rs5760509; rs12168759; rs9620404; rs4049870; rs9612673; rs5760510; rs4049836; rs28441370; rs12170528; rs4049849; rs4049827; rs4049851; rs3865655; rs4049872; rs3865650; rs6004205; rs5751911; rs4049858; rs4049879; rs2877229; rs2330845; rs6004201; rs12159496; rs4426615; rs4049838; rs2877230; rs12168762; rs28418841; rs4049877; rs3876106; rs28477676; rs5760503; rs3938847; rs9620400; rs2330847; rs4049842; rs28402861; rs28718168; rs3865658; rs4049856; rs2877227; rs12166510; rs4049832; rs7284160; rs2105500; rs11416248; rs493075; rs2877231; rs3966265; rs2330851; rs3966264; rs6004198; rs3897519; rs4049864; rs4049854; rs4049830; rs3865656; rs2845424; rs9612672; rs5751465; rs4049871; rs11912608; rs9620401; rs2330840; rs4049859; rs28451181; rs4049834; rs4049862; rs9612679; rs3034881; rs4049874; rs3865652; rs35525727; rs3035043; rs12158857; rs2330854; rs35882418; rs5760483; rs11318518; rs11913638; rs12158094; rs16978739; rs2070477; rs2154611; rs4820599; rs5760485; rs5760488; rs7287904; rs737128; rs743369; rs743370; rs762286; rs874852; rs928785; rs9608299; rs9830

# Metabolic_Enzyme_10_General_References:
2904146; 2907498; 2563599; 2568315; 1968061; 1378736; 7689219; 10591208; 2896486; 10392451; 19463; 2900635; 8095045; 7759490; 7673200; 8827453

# Metabolic_Enzyme_10_References:
16519608; 16579779; 16579781; 16644880

# Macromolecular_Interacting_Partner_1_ID:
7556

# Macromolecular_Interacting_Partner_1_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_1_Signals:
1-18

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_1_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_1_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_1_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_1_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_1_References:
16107673; 16201899; 16579779; 16579781

# Macromolecular_Interacting_Partner_2_ID:
7860

# Macromolecular_Interacting_Partner_2_Name:
Myoglobin

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
MB

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Myoglobin
MGLSDGEWQLVLNVWGKVEADIPGHGQEVLIRLFKGHPETLEKFDKFKHLKSEDEMKASE
DLKKHGATVLTALGGILKKKGHHEAEIKPLAQSHATKHKIPVKYLEFISECIIQVLQSKH
PGDFGADAQGAMNKALELFRKDMASNYKELGFQG

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
154

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
17184

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
7.86

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  oxygen binding
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
 ||
>>>
Process:  gas transport
Process:  oxygen transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00042:Globin

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
1235527

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
MYG_HUMAN (P02144)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
MB

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
MB

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:6915

# Macromolecular_Interacting_Partner_2_PDB_ID:
2MM1

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>95 bp
ATGGGGCTCAGCGACGGGGAATGGCAGTTGGTGCTGAACGTCTGGGGGAAGGTGGAGGCT
GACATCCCAGGCCATGGGCAGGAAGTCCTCATCAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
X00371

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_2_Locus:
22q13.1

# Macromolecular_Interacting_Partner_2_SNPs:
rs7292; rs7293; rs1056680; rs1997882; rs8136856; rs5750136; rs5750135; rs8140955; rs8140917; rs8140868; rs8140953; rs8141044; rs8137205; rs8141731; rs8141728; rs8141048; rs8140754; rs2899254; rs916230; rs2076141; rs5755790; rs5755791; rs5750130; rs5750132; rs5755794; rs16995880; rs5755799; rs2179870; rs2283962; rs5755795; rs5755797; rs5755793; rs762911; rs5750133; rs5755798; rs5755789; rs17722766; rs2283963; rs5999890; rs5750131; rs5755796; rs5750134; rs16995883; rs17795829; rs4821424; rs5995129; rs5755788; rs4140603; rs4820205; rs4140604; rs4821423; rs3788512; rs16995876; rs5755800; rs35469011; rs35479350; rs13056550; rs13056588; rs28564512; rs35884692; rs8136969; rs13056581; rs5999892; rs5995128; rs13056580; rs17722736; rs1076908; rs35141221; rs34697597; rs35171458; rs1076909; rs11705485; rs5755792; rs8137225; rs34126675; rs5750137; rs7292530; rs34893226; rs1012901; rs11912845; rs1476000; rs17842411; rs4497964; rs4622835; rs4821419; rs4821420; rs4821421; rs4821422; rs5750124; rs5750125; rs5750126; rs5755781; rs5999885; rs5999888; rs5999894; rs9607278

# Macromolecular_Interacting_Partner_2_General_References:
6571704; 2989088; 10591208; 5285572; 4627044; 7895732; 5805522; 5555219; 5555226; 5540041; 2342104

# Macromolecular_Interacting_Partner_2_References:
15981298; 16293154; 16569563; 16920153

# Macromolecular_Interacting_Partner_3_ID:
8427

# Macromolecular_Interacting_Partner_3_Name:
Myogenin

# Macromolecular_Interacting_Partner_3_Synonyms:
Myogenic factor 4; Myf-4

# Macromolecular_Interacting_Partner_3_Gene_Name:
MYOG

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Myogenin
MELYETSPYFYQEPRFYDGENYLPVHLQGFEPPGYERTELTLSPEAPGPLEDKGLGTPEH
CPGQCLPWACKVCKRKSVSVDRRRAATLREKRRLKKVNEAFEALKRSTLLNPNQRLPKVE
ILRSAIQYIERLQALLSSLNQEERDLRYRGGGGPQPGVPSECSSHSASCSPEWGSALEFS
ANPGDHLLTADPTDAHNLHSLTSIVDSITVEDVSVAFPDETMPN

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
224

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
25037

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
5.38

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  transcription regulator activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  development
Process:  organ development
Process:  muscle development
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF01586:Basic;
PF00010:HLH

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
34834

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
MYOG_HUMAN (P15173)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
MYOG

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
MYOG

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:7612

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>671 bp
ATGGAGCTGTATGAGACATCCCCCTACTTCTACCAGGAACCCCGCTTCTATGATGGGGAA
AACTACCTGCCTGTCCACCTCCAGGGCTTCGAACCACCAGGCTACGAGCGGACGGAGCTC
ACCCTGAGCCCCGAGGCCCCAGGGCCCCTTGAGGACAAGGGGCTGGGGACCCCCGAGCAC
TGTCCAGGCCAGTGCCTGCCGTGGGCGTGTAAGGTGTGTAAGAGGAAGTCGGTGTCCGTG
GACCGGCGGCGGGCGGCCACACTGAGGGAGAAGCGCAGGCTCAAGAAGGTGAATGAGGCC
TTCGAGGCCCTGAAGAGAAGCACCCTGCTCAACCCCAACCAGCGGCTGCCCAAGGTGGAG
ATCCTGCGCAGTGCCATCCAGTACATCGAGCGCCTCCAGGCCCTGCTCAGCTCCCTCAAC
CAGGAGGAGCGTGACCTCCGCTACCGGGGCGGGGGCGGGCCCCAGCCAGGGGTGCCCAGC
GAATGCAGCTCTCACAGCGCCTCCTGCAGTCCAGAGTGGGGCAGTGCACTGGAGTTCAGC
GCCAACCCAGGGGATCATCTGCTCACGGCTGACCCTACAGATGCCCACAACCTGCACTCC
CTCACCTCCATCGTGGACAGCATCACAGTGGAAGATGTGTCTGTGGCCTTCCCAGATGAA
ACCATGCCCAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
X62155

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_3_Locus:
1q31-q41

# Macromolecular_Interacting_Partner_3_SNPs:
rs2071452; rs4950877; rs3737878; rs11807924; rs903356; rs3737877; rs10753935; rs1532324; rs3753483; rs11588424; rs6694124; rs10920562; rs3835486; rs34009140; rs923950; rs12143972; rs10690807; rs34465347; rs3753482; rs35642106; rs12142721; rs12092391; rs3737876; rs3753481; rs3753480; rs12142753; rs1004594; rs1038984; rs10920561; rs10920563; rs10920564; rs11578206; rs11580190; rs11585814; rs12063282; rs12079135; rs1874141; rs1999926; rs2364571; rs2886116; rs3087949; rs34617011; rs35500114; rs35680180; rs3737879; rs3737880; rs3753477; rs3795585; rs3795586; rs3820151; rs4641350; rs6682652; rs6692698; rs7514834; rs903365; rs903366

# Macromolecular_Interacting_Partner_3_General_References:
1659574; 2583111

# Macromolecular_Interacting_Partner_3_References:
16378590; 16461349; 17045567

# Macromolecular_Interacting_Partner_4_ID:
8380

# Macromolecular_Interacting_Partner_4_Name:
Sodium- and chloride-dependent creatine transporter 1

# Macromolecular_Interacting_Partner_4_Synonyms:
CT1; Creatine transporter 1; Solute carrier family 6 member 8

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC6A8

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Sodium and chloridedependent creatine transporter 1
MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMD
FIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGS
INVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPD
CVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLL
ACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKL
GSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVF
SILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFV
GVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASG
TTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV
YYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWG
LHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
635

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
70523

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.38

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
Function:  transporter activity
Function:  cofactor transporter activity
Function:  creatine transporter activity
Function:  creatine:sodium symporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Required for the uptake of creatine in muscles and brain

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
61-81
88-108
139-159
231-251
270-290
305-325
342-362
395-415
445-465
480-500
521-541
561-581

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
493132

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
SC6A8_HUMAN (P48029)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC6A8

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC6A8

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11055

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1908 bp
ATGGCGAAGAAGAGCGCCGAGAACGGCATCTATAGCGTGTCCGGCGACGAGAAGAAGGGC
CCCCTCATCGCGCCCGGGCCCGACGGGGCCCCGGCCAAGGGCGACGGCCCCGTGGGCCTG
GGGACACCCGGCGGCCGCCTGGCCGTGCCGCCGCGCGAGACCTGGACGCGCCAGATGGAC
TTCATCATGTCGTGCGTGGGCTTCGCCGTGGGCTTGGGCAACGTGTGGCGCTTCCCCTAC
CTGTGCTACAAGAACGGCGGAGGTGTGTTCCTTATTCCCTACGTCCTGATCGCCCTGGTT
GGAGGAATCCCCATTTTCTTCTTAGAGATCTCGCTGGGCCAGTTCATGAAGGCCGGCAGC
ATCAATGTCTGGAACATCTGTCCCCTGTTCAAAGGCCTGGGCTACGCCTCCATGGTGATC
GTCTTCTACTGCAACACCTACTACATCATGGTGCTGGCCTGGGGCTTCTATTACCTGGTC
AAGTCCTTTACCACCACGCTGCCCTGGGCCACATGTGGCCACACCTGGAACACTCCCGAC
TGCGTGGAGATCTTCCGCCATGAAGACTGTGCCAATGCCAGCCTGGCCAACCTCACCTGT
GACCAGCTTGCTGACCGCCGGTCCCCTGTCATCGAGTTCTGGGAGAACAAAGTCTTGAGG
CTGTCTGGGGGACTGGAGGTGCCAGGGGCCCTCAACTGGGAGGTGACCCTTTGTCTGCTG
GCCTGCTGGGTGCTGGTCTACTTCTGTGTCTGGAAGGGGGTCAAATCCACGGGAAAGATC
GTGTACTTCACTGCTACATTCCCCTACGTGGTCCTGGTCGTGCTGCTGGTGCGTGGAGTG
CTGCTGCCTGGCCCCCTGGATGGCATCATTTACTATCTCAAGCCTGACTGGTCAAAGCTG
GGGTCCCCTCAGGTGTGGATAGATGCGGGGACCCAGATTTTCTTTTCTTACGCCATTGGC
CTGGGGGCCCTCACAGCCCTGGGCAGCTACAACCGCTTCAACAACAACTGCTACAAGGAC
GCCATCATCCTGGCTCTCATCAACAGTGGGACCAGCTTCTTTGCTGGCTTCGTGGTCTTC
TCCATCCTGGGCTTCATGGCTGCAGAGCAGGGCGTGCACATCTCCAAGGTGGCAGAGTCA
GGGCCGGGCCTGGCCTTCATCGCCTACCCGCGGGCTGTCACGCTGATGCCAGTGGCCCCA
CTCTGGGCTGCCCTGTTCTTCTTCATGCTGTTGCTGCTTGGTCTCGACAGCCAGTTTGTA
GGTGTGGAGGGCTTCATCACCGGCCTCCTCGACCTCCTCCCGGCCTCCTACTACTTCCGT
TTCCAAAGGGAGATCTCTGTGGCCCTCTGTTGTGCCCTCTGCTTTGTCATCGATCTCTCC
ATGGTGACTGATGGCGGGATGTACGTCTTCCAGCTGTTTGACTACTACTCGGCCAGCGGC
ACCACCCTGCTCTGGCAGGCCTTTTGGGAGTGCGTGGTGGTGGCCTGGGTGTACGGAGCT
GACCGCTTCATGGACGACATTGCCTGTATGATCGGGTACCGACCTTGCCCCTGGATGAAA
TGGTGCTGGTCCTTCTTCACCCCGCTGGTCTGCATGGGCATCTTCATCTTCAACGTTGTG
TACTACGAGCCGCTGGTCTACAACAACACCTACGTGTACCCGTGGTGGGGTGAGGCCATG
GGCTGGGCCTTCGCCCTGTCCTCCATGCTGTGCGTGCCGCTGCACCTCCTGGGCTGCCTC
CTCAGGGCCAAGGGCACCATGGCTGAGCGCTGGCAGCACCTGACCCAGCCCATCTGGGGC
CTCCACCACTTGGAGTACCGAGCTCAGGACGCAGATGTCAGGGGCCTGACCACCCTGACC
CCAGTGTCCGAGAGCAGCAAGGTCGTCGTGGTGGAGAGTGTCATGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
L31409

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_4_Locus:
Xq28

# Macromolecular_Interacting_Partner_4_SNPs:
rs3179358; rs6571290; rs4532754; rs13120; rs6571288; rs6643764; rs2097221; rs2314079; rs2314078; rs35880208; rs11548959; rs4065272; rs11548960; rs2872523; rs2872524; rs1060453; rs1803332; rs2314070; rs1803330; rs2314081; rs3861557; rs3861555; rs3969135; rs4898436; rs1811105; rs2097220; rs1803331; rs3969136; rs3861556; rs34870027; rs11548961; rs4065268; rs3850325; rs2314080; rs5945340; rs12833566; rs2314073; rs2872520; rs2314067; rs2314072; rs2314069; rs28603260; rs2872521; rs2314066; rs41299114; rs2314071; rs34305716; rs2872519; rs2872518; rs2314075; rs5987131; rs2872522; rs2314077; rs6643763; rs5987132; rs41301325; rs6655262; rs2314074; rs2314076; rs34035058; rs41302172; rs2071028; rs2314068; rs6643642; rs12008445; rs12353769; rs13126; rs2266864; rs2266865; rs2266866; rs2283749; rs2314082; rs2314083; rs2872525; rs371296; rs3761533; rs409702; rs438068; rs454730; rs5986919; rs5986924; rs5987129

# Macromolecular_Interacting_Partner_4_General_References:
7953292; 7945388; 8661155

# Macromolecular_Interacting_Partner_4_References:
16036218; 16086185; 16763899; 16849631

# Macromolecular_Interacting_Partner_5_ID:
8230

# Macromolecular_Interacting_Partner_5_Name:
Myosin

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Myosin
ETTKLILQFLATISGQDSWIEQQVLEANPIL

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
31

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
3500

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
3.78

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  motor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  protein complex
Component:  myosin

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00063:Myosin_head

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
531140

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
Q14786_HUMAN (Q14786)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_5_hgnc_id:
Not Available

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>93 bp
GAGACCACCAAGCTCATCCTGCAGTTCCTGGCCACCATCAGTGGCCAGGATTCGTGGATT
GAGCAGCAGGTCCTGGAAGCCAACCCCATCCTG

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
L29147

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Locus:
Not Available

# Macromolecular_Interacting_Partner_5_SNPs:
Not Available

# Macromolecular_Interacting_Partner_5_General_References:
8022818

# Macromolecular_Interacting_Partner_5_References:
16461349; 17045567; 17147430

End of HMDB00064

Beginning of HMDB00067
# Accession_No:
HMDB00067

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-24 10:46:09

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Cholesterol

# Description:
Cholesterol is a sterol (a combination steroid and alcohol) and a lipid found in the cell membranes of all body tissues, and transported in the blood plasma of all animals. The name originates from the Greek chole- (bile) and stereos (solid), and the chemical suffix -ol for an alcohol, as researchers first identified cholesterol (C27H45OH) in solid form in gallstones in 1784. Cholesterol is transported throughout the body via lipoprotein particles.  The largest lipoproteins, which primarily transport fats from the intestinal mucosa to the liver, are called chylomicrons. They carry mostly triglyceride fats and cholesterol (that are from food and especially internal cholesterol secreted by the liver into the bile). In the liver, chylomicron particles give up triglycerides and some cholesterol, and are converted into low-density lipoprotein (LDL) particles, which carry triglycerides and cholesterol on to other body cells. In healthy individuals the LDL particles are large and relatively few in number. In contrast, large numbers of small LDL particles are strongly associated with promoting atheromatous disease within the arteries. (Lack of information on LDL particle number and size is one of the major problems of conventional lipid tests.).  In conditions with elevated concentrations of oxidized LDL particles, especially small LDL particles, cholesterol promotes atheroma plaque deposits in the walls of arteries, a condition known as atherosclerosis, which is a major contributor to coronary heart disease and other forms of cardiovascular disease. (In contrast, HDL particles have been the only identified mechanism by which cholesterol can be removed from atheroma. Increased concentrations of large HDL particles, not total HDL particles, correlate with lower rates of atheroma progressions, even regression.). There is a world-wide trend to believe that lower total cholesterol levels tend to correlate with lower atherosclerosis event rates (though many studies refute this idea). Due to this reason, cholesterol has become a very large focus for scientific researchers trying to determine the proper amount of cholesterol needed in a healthy diet. However, the primary association of atherosclerosis with cholesterol has always been specifically with cholesterol transport patterns, not total cholesterol per se. For example, total cholesterol can be low, yet made up primarily of small LDL and small HDL particles and atheroma growth rates are high. In contrast, however, if LDL particle number is low (mostly large particles) and a large percentage of the HDL particles are large (HDL is actively reverse transporting cholesterol), then atheroma growth rates are usually low, even negative, for any given total cholesterol concentration. These effects are further complicated by the relative concentration of asymmetric dimethylarginin (ADMA) in the endothelium, since ADMA down-regulates production of nitric oxide, a relaxant of the endothelium. Thus, high levels of ADMA, associated with high oxidized levels of LDL pose a heightened risk factor for vascular disease. -- Wikipedia

# Synonyms:
(+)-ent-Cholesterol; (-)-Cholesterol; (20bFH)-cholest-5-en-3b-ol; (3b)-cholest-5-en-3-ol; (3beta)-Cholest-5-en-3-ol; 20-epi-cholesterol; 20-iso-cholesterol; 20bFH-cholest-5-en-3b-ol; 3beta-Hydroxycholest-5-ene; 5-Cholesten-3B-ol; 5-Cholesten-3beta-ol; 5:6-Cholesten-3-ol; 5:6-Cholesten-3beta-ol; Cholest-5-en-3-ol; Cholest-5-en-3beta-ol; Cholesterin; Cholesterine; Cholesterol; Cholesterol base H; Cholesteryl alcohol; Cholestrin; Cholestrol; Cordulan; Dastar; Dusoline; Dusoran; Dythol; Epicholesterol; Fancol CH; Hydrocerin; Kathro; Lanol; Liquid crystal CN/9; Nimco cholesterol base H; Nimco cholesterol base No. 712; Super hartolan; Tegolan; cholest-5-en-3b-ol; epicholesterin

# Chemical_IUPAC_Name:
10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

# Chemical_Formula:
C27H46O

# Chemical_Structure:
tbl_chemical:::HMDB00067_ZOOM.png:::119283170028877217

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00067_THUMB.png:::119283169818547834

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Sterols

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
secondary alcohol; alkene

# Taxonomy_Biofunction:
Component of Bile acid biosynthesis; Component of C21-Steroid hormone metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
386.35486

# Molecular_Weight_Avg:
386.65353

# Smiles_String_isomeric:
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4CC(O)CC[C@]4(C)[C@H]3CC[C@]12C

# Smiles_String_canonical:
CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C

# KEGG_Compound_ID:
C00187

# BioCyc_ID:
CHOLESTEROL

# PubChem_CID:
5997

# PubChem_SID:
629186; 4266362; 12252776; 827331; 8153730; 74414; 711067; 8025561; 3132495; 7847108; 8145005; 148845; 10318723; 10586602; 7886645; 825929; 841782; 3487

# OMIM_ID:
142910; 260900; 270400; 278000; 600046; 604595; 607053; 607687

# Metagene_ID:
GLYCOGENOSIS, TYPE IXB: 170; CYSTINOSIS: 104; LECITHIN:CHOLESTEROL ACYLTRANSFERASE DEFICIENCY: 492; CHONDRODYSPLASIA PUNCTATA, X-LINKED DOMINANT: 91; PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 2 (PEPCK2): 262; GLYCOGENOSIS, TYPE IC: 158; HYPERCHOLESTEROLEMIA, FAMILIAL: 205; NIEMANN-PICK DISEASE TYPE C: 315; PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS: 363; GLYCOGENOSIS, TYPE VI. HERS DISEASE: 166; CHOLESTERYL ESTER STORAGE DISEASE: 88; OCULOCEREBRORENAL SYNDROME OF LOWE: 344; CONGENITAL DISORDER OF GLYCOSYLATION CDG-Ib: 444; TANGIER DISEASE: 494; MEVALONIC ACIDURIA: 16; GLYCOGENOSIS, TYPE IB: 157; 27-HYDROXYLASE DEFICIENCY: 364; GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE: 156; APOLIPOPROTEIN C-II DEFICIENCY: 326; TRIHYDROXYCOPROSTANIC ACIDEMIA. COPROSTANIC ACIDEMIA: 20; GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS: 163; ABETALIPOPROTEINEMIA, BASSEN-KORNZWEIG-SYNDROME, ACANTHOCYTOSIS (ABL): 379; SMITH-LEMLI-OPITZ SYNDROME: 337; 3-METHYLGLUTACONIC ACIDURIA, X-LINKED (TYPE II): 24; GLYCOGENOSIS, TYPE IXA: 169; CHILD SYNDROME: 496; CONGENITAL DISORDER OF GLYCOSYLATION CDG-Ia: 293; FISH-EYE DISEASE: 493; HYPERCHOLESTEROLEMIA, AUTOSOMAL DOMINANT, TYPE B: 242

# BiGG_ID:
34183

# Wikipedia_ID:
Cholesterol

# METLIN_ID:
163

# Ref_ID:
16866910; 8651245; 15179829; 16701946; 16636218; 9027647; 985740; 9266395; 9004852; 8462368; 16762001; 7709184; 1772471; 3012338; 16635110; 8591852; 15576852; 1465059; 3885567

# ChEBI_ID:
16113

# CAS_Registry_Number:
57-88-5

# InChI:
InChI=1/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21?,22+,23-,24+,25+,26+,27-/m1/s1

# Synthesis_Reference:
he action of iodides on sterol dibromides and the preparation of cholestenone.     Schoenheimer, Rudolph.    Journal of Biological Chemistry  (1935),  110  461-2.

# Melting_Point:
148 oC

# Melting_Point_predicted:
130.8 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
9.5e-05 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
2.79e-05 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
7.02 [Predicted by ALOGPS]; 8.2 [Predicted by PubChem via XLOGP]; 8.74 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Cholesterol.pdf:::1132562196203513229

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Cholesterol.mol:::1132723804781681462

# SDF_File_[Text]:
tbl_chemical:::HMDB00067.sdf:::119283168968115069

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00067.pdb:::119283169562638140

# PDB_ID:
1LRI

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1LRI.txt:::1132720900859519366

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::00067_Cholesterol.zip:::118289487311812066

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041024_P00_01_HW_assigned.png:::118289487315628788

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041024_P00_01_HW_2DHSQC_41.png:::114828643007275528

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041024_P00_01_HW_2DHSQC_41.zip:::11482864300793249

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041024_P00_01_HW_2DHSQC_41_Assigned.png:::116240974406591868

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Cholesterol.gif:::1132732104875960068

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00067_peaks.txt:::1156309523497992217

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Cholesterol_C.gif:::1132737673731419038

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00067_peaks.txt:::115631071392413854

# Mass_Spectrum:
tbl_chemical:::HMDB00067.jpg:::1132798876265654476

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane; Cytoplasm; endoplasmic reticulum; Extracellular; golgi apparatus; lysosome; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Bile; Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Blood	1300.0 (700.0-1900.0)	umol/L	Adult:>18_yrs_old	Male	Normal	Wikipedia
Blood	0.00-3360.0	umol/L	Adult:>18_yrs_old	Both	Normal	Merck Manual
Blood	3100.0 +/- 230.0	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	4.30 (3.90-4.70)	umol/L	Adult:>18_yrs_old	Both	Normal	9266395
Cerebrospinal_Fluid(CSF)	8.32 (7.88-8.76)	umol/L	Adult:>18_yrs_old	Both	Normal	15576852
Saliva	<1.00	umol/L	Adult:>18_yrs_old	Both	Normal	15179829
Bile	11500(10000-13000)	umol/L	Adult:>18_yrs_old	Both	Normal	8462368


# Concentration_[Abnormal]:
Urine	1.1	umol/L	Infant:0-1_yr_old	Both	Smith-Lemli-Opitz syndrome	9266395
Cerebrospinal_Fluid(CSF)	10.9 +/- 2.7 	umol/L	Adult:>18_yrs_old	Both	Multiple Sclerosis	15576852
Bile	13100 (10900-15300)	umol/L	Adult:>18_yrs_old	Both	Gallstone disease	8591852
Bile	13900 (13100-14700)	umol/L	Adult:>18_yrs_old	Both	Cholesterol stones	8591852
Bile	15110 (9860-20360)	umol/L	Adult:>18_yrs_old	Both	Gastric cancer	9027647
Bile	16700 (14100-19300)	umol/L	Adult:>18_yrs_old	Both	Gallstone disease	8462368


# Associated_Disorders:
27-Hydroxylase Deficiency; 3-Methylglutaconic Aciduria, X-Linked (Type II); Abetalipoproteinemia; Acanthocytosis (ABL); Aortic Atherosclerosis; Apolipoprotein C-II Deficiency; Atherosclerosis; Bassen-Kornzweig-Syndrome; Borderline-high; Child Syndrome; Cholesterol stones; Cholesteryl Ester Storage Disease; Chondrodysplasia Punctata, X-Linked Dominant; Congenital Disorder of Glycosylation CDG-IA; Congenital Disorder of Glycosylation CDG-IB; Coprostanic Acidemia; Cori Disease; Crohn's disease; Cystinosis; Debrancher Glycogenosis; Familial Hypercholesterolemia; Female; Fish-Eye Disease; Gallstone disease; Gastric cancer; Glycogenosis, Type IB; Glycogenosis, Type IC; Glycogenosis, Type III; Glycogenosis, Type IXA; Glycogenosis, Type IXB; Glycogenosis, Type VI; Hers Disease; High; Hypercholesterolemia, Autosomal Dominant, Type B; Lecithin:Cholesterol Acyltransferase Deficiency; Metabolic Syndrome; Mevalonic Aciduria; Minimal Brain Dysfunction; Multiple Sclerosis; Niemann-Pick Disease Type C; Oculocerebrorenal Syndrome of Lowe; Phosphoenolpyruvate Carboxykinase Deficiency 2 (PEPCK2); Progressive Familial Intrahepatic Cholestasis; Smith-Lemli-Opitz Syndrome; Tangier Disease; Trihydroxycoprostanic Acidemia

# Pathway_Names:
Bile acid biosynthesis;Biosynthesis of steroids;C21-Steroid hormone metabolism

# Pathway_Images:
;;

# KEGG_Images:
map00120;map00100;map00140

# Pathway_Graphs:
;;

# Pathway_SBMLs:
;;

# Metabolic_Enzyme_1_ID:
5746

# Metabolic_Enzyme_1_Name:
Sterol O-acyltransferase 2

# Metabolic_Enzyme_1_Synonyms:
Cholesterol acyltransferase 2; Acyl coenzyme A:cholesterol acyltransferase 2; ACAT-2

# Metabolic_Enzyme_1_Gene_Name:
SOAT2

# Metabolic_Enzyme_1_Protein_Sequence:
>Sterol Oacyltransferase 2
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQL
RELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHF
RTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLA
PYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFL
MKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKN
FAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLH
CWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARG
VAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTM
LFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT

# Metabolic_Enzyme_1_Number_of_Residues:
522

# Metabolic_Enzyme_1_Molecular_Weight:
59897

# Metabolic_Enzyme_1_Theoretical_pI:
8.71

# Metabolic_Enzyme_1_GO_Classification:
Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa

# Metabolic_Enzyme_1_Pathway:
map00120  Bile acid biosynthesis

# Metabolic_Enzyme_1_Reaction:
acyl-CoA + cholesterol = CoA + cholesterol ester

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF03062:MBOAT

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
124-144
155-175
200-220
262-282
304-324
344-366
437-457
472-492

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.3.1.26

# Metabolic_Enzyme_1_GenBank_ID_Protein:
3746535

# Metabolic_Enzyme_1_SwissProt_ID:
SOAT2_HUMAN (O75908)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
SOAT2

# Metabolic_Enzyme_1_Geneatlas_id:
SOAT2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:11178

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein

# Metabolic_Enzyme_1_Gene_Sequence:
>1569 bp
ATGGAGCCAGGCGGGGCCCGTCTGCGTCTGCAGAGGACAGAAGGGCTGGGAGGGGAGCGG
GAGCGCCAACCCTGTGGAGATGGAAACACTGAGACGCACAGAGCCCCGGACTTGGTACAA
TGGACCCGACACATGGAGGCTGTGAAGGCACAATTGCTGGAGCAAGCGCAGGGACAACTG
AGGGAGCTGCTGGATCGGGCCATGCGGGAGGCTATACAATCCTACCCATCACAAGACAAA
CCTCTGCCCCCACCTCCCCCAGGTTCCTTGAGCAGGACCCAGGAGCCATCCCTGGGGAAA
CAGAAAGTTTTCATCATCCGCAAGTCCCTGCTTGATGAGCTGATGGAGGTGCAGCATTTC
CGCACCATCTACCACATGTTCATCGCTGGCCTGTGTGTCTTCATCATCAGCACCCTGGCC
ATCGACTTCATTGATGAGGGCAGGCTGCTGCTGGAGTTTGACCTACTGATCTTCAGCTTC
GGACAGCTGCCATTGGCGCTGGTGACCTGGGTGCCCATGTTTCTGTCCACCCTGTTGGCG
CCGTACCAGGCCCTACGGCTGTGGGCCAGGGGCACCTGGACGCAGGCGACGGGCCTGGGC
TGTGCGCTGCTAGCCGCCCACGCCGTGGTGCTCTGCGCGCTGCCGGTCCACGTGGCCGTG
GAGCATCAGCTCCCGCCGGCCTCCCGTTGTGTCCTGGTCTTCGAGCAGGTTAGGTTCCTG
ATGAAAAGCTACTCCTTCCTGAGAGAGGCTGTGCCTGGGACCCTTCGTGCCAGACGAGGT
GAGGGGATCCAGGCCCCCAGTTTCTCCAGCTACCTCTACTTCCTCTTCTGCCCAACACTC
ATCTACAGGGAGACTTACCCTAGGACGCCCTATGTCAGGTGGAATTATGTGGCCAAGAAC
TTTGCCCAGGCCCTGGGATGTGTGCTCTATGCCTGCTTCATCCTGGGCCGCCTCTGTGTT
CCTGTCTTTGCCAACATGAGCCGAGAGCCCTTCAGCACCCGTGCCCTGGTGCTCTCTATC
CTGCATGCCACGTTGCCAGGCATCTTCATGCTGCTGCTCATCTTCTTTGCCTTCCTCCAT
TGCTGGCTCAACGCCTTTGCCGAGATGCTACGATTTGGAGACAGGATGTTCTACCGGGAC
TGGTGGAACTCAACGTCCTTCTCCAACTACTACCGCACTTGGAACGTGGTGGTCCATGAC
TGGCTGTACAGCTACGTGTATCAGGATGGGCTGCGGCTCCTTGGTGCCCGGGCCCGAGGG
GTAGCCATGCTGGGTGTGTTCCTGGTCTCCGCAGTGGCCCATGAGTATATCTTCTGCTTC
GTCCTGGGGTTCTTCTATCCCGTCATGCTGATACTCTTCCTTGTCATTGGAGGAATGTTG
AACTTCATGATGCATGACCAGCGCACCGGCCCGGCATGGAACGTGCTGATGTGGACCATG
CTGTTTCTAGGCCAGGGAATCCAGGTCAGCCTGTACTGCCAGGAGTGGTACGCACGGCGG
CACTGCCCCTTACCCCAGGCAACTTTCTGGGGGCTGGTGACACCTCGATCTTGGTCCTGC
CATACCTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF059203

# Metabolic_Enzyme_1_Chromosome_Location:
Not Available

# Metabolic_Enzyme_1_Locus:
Not Available

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
9756920; 10846185; 11325614; 11401500

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5749

# Metabolic_Enzyme_2_Name:
Cytochrome P450 7A1

# Metabolic_Enzyme_2_Synonyms:
Cholesterol 7-alpha-monooxygenase; CYPVII; Cholesterol 7-alpha-hydroxylase

# Metabolic_Enzyme_2_Gene_Name:
CYP7A1

# Metabolic_Enzyme_2_Protein_Sequence:
>Cytochrome P450 7A1
MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQ
RKHGHVFTCK
LMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDG
NTTENINDTFIKTLQGHALNS
LTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRV
MFEAGYLTIFGRDLTRRDTQKAHILNNLDNFK
QFDKVFPALVAGLPIHMFRTAHNAREK
LAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHL
VVLWASQANTIPATFW
SLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSII
KESLR
LSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDE
NGKTK
TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQA
KCPPLDQSRAGLGILP
PLNDIEFKYKFKHL

# Metabolic_Enzyme_2_Number_of_Residues:
504

# Metabolic_Enzyme_2_Molecular_Weight:
57661

# Metabolic_Enzyme_2_Theoretical_pI:
8.34

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_2_Specific_Function:
Cholesterol + NADPH + O(2) = 7-alpha- hydroxycholesterol + NADP(+) + H(2)O

# Metabolic_Enzyme_2_Pathway:
map00120  Bile acid biosynthesis

# Metabolic_Enzyme_2_Reaction:
cholesterol + NADPH + H+ + O2 = 7alpha-hydroxycholesterol + NADP+ + H2O

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_2_Signals:
1-23

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.14.13.17

# Metabolic_Enzyme_2_GenBank_ID_Protein:
23909

# Metabolic_Enzyme_2_SwissProt_ID:
CP7A1_HUMAN (P22680)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
CYP7A1

# Metabolic_Enzyme_2_Geneatlas_id:
CYP7A1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:2651

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein

# Metabolic_Enzyme_2_Gene_Sequence:
>1515 bp

ATGATGACCACATCTTTGATTTGGGGGATTGCTATAGCAGCATGCTGTTGTCTATGGCT
TATTCTTGGAA
TTAGGAGAAGGCAAACGGGTGAACCACCTCTAGAGAATGGATTAATTC
CATACCTGGGCTGTGCTCTGCA
ATTTGGTGCCAATCCTCTTGAGTTCCTCAGAGCAAAT
CAAAGGAAACATGGTCATGTTTTTACCTGCAAA
CTAATGGGAAAATATGTCCATTTCAT
CACAAATCCCTTGTCATACCATAAGGTGTTGTGCCACGGAAAAT
ATTTTGATTGGAAAA
AATTTCACTTTGCTACTTCTGCGAAGGCATTTGGGCACAGAAGCATTGACCCGAT
GGAT
GGAAATACCACTGAAAACATAAACGACACTTTCATCAAAACCCTGCAGGGCCATGCCTTG
AATTCC
CTCACGGAAAGCATGATGGAAAACCTCCAACGTATCATGAGACCTCCAGTCTC
CTCTAACTCAAAGACCG
CTGCCTGGGTGACAGAAGGGATGTATTCTTTCTGCTACCGAG
TGATGTTTGAAGCTGGGTATTTAACTAT
CTTTGGCAGAGATCTTACAAGGCGGGACACA
CAGAAAGCACATATTCTAAACAATCTTGACAACTTCAAG
CAATTCGACAAAGTCTTTCC
AGCCCTGGTAGCAGGCCTCCCCATTCACATGTTCAGGACTGCGCACAATG
CCCGGGAGA
AACTGGCAGAGAGCTTGAGGCACGAGAACCTCCAAAAGAGGGAAAGCATCTCAGAACTGA
T
CAGCCTGCGCATGTTTCTCAATGACACTTTGTCCACCTTTGATGATCTGGAGAAGGCC
AAGACACACCTC
GTGGTCCTCTGGGCATCGCAAGCAAACACCATTCCAGCGACTTTCTG
GAGTTTATTTCAAATGATTAGGA
ACCCAGAAGCAATGAAAGCAGCTACTGAAGAAGTGA
AAAGAACATTAGAGAATGCTGGTCAAAAAGTCAG
CTTGGAAGGCAATCCTATTTGTTTG
AGTCAAGCAGAACTGAATGACCTGCCAGTATTAAATAGTATAATC
AAGGAATCGCTGAG
GCTTTCCAGTGCCTCCCTCAACATCCGGACAGCTAAGGAGGATTTCACTTTGCACC
TTG
AGGACGGTTCCTACAACATCCGAAAAGATAGCATCATAGCTCTTTACCCACAGTTAATGC
ACTTAGA
TCCAGAAATCTACCCAGACCCTTTGACTTTTAAATATGATAGGTATCTTGAT
GAAAACGGGAAGACAAAG
ACTACCTTCTATTGTAATGGACTCAAGTTAAAGTATTACTA
CATGCCCTTTGGATCGGGAGCTACAATAT
GTCCTGGAAGATTGTTCGCTATCCACGAAA
TCAAGCAATTTTTGATTCTGATGCTTTCTTATTTTGAATT
GGAGCTTATAGAGGGCCAA
GCTAAATGTCCACCTTTGGACCAGTCCCGGGCAGGCTTGGGCATTTTGCCG
CCATTGAA
TGATATTGAATTTAAATATAAATTCAAGCATTTGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X56088

# Metabolic_Enzyme_2_Chromosome_Location:
Not Available

# Metabolic_Enzyme_2_Locus:
Not Available

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
8439551; 2384150; 1610352; 8020987; 1312351; 12721789

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5459

# Metabolic_Enzyme_3_Name:
Lysosomal acid lipase/cholesteryl ester hydrolase precursor

# Metabolic_Enzyme_3_Synonyms:
LAL; Acid cholesteryl ester hydrolase; Sterol esterase; Lipase A; Cholesteryl esterase

# Metabolic_Enzyme_3_Gene_Name:
LIPA

# Metabolic_Enzyme_3_Protein_Sequence:
>Lysosomal acid lipase/cholesteryl ester hydrolase precursor
MKMRFLGLVVCLVLWTLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYI
LCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNS
RGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIG
FIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPDHLIKDLFGDKEFLPQSAFL
KWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAV
KFQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLTQI
TNLVFHESIPEWEHLDFIWGLDAPWRLYNKIINLMRKYQ

# Metabolic_Enzyme_3_Number_of_Residues:
399

# Metabolic_Enzyme_3_Molecular_Weight:
45419

# Metabolic_Enzyme_3_Theoretical_pI:
6.91

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation

# Metabolic_Enzyme_3_Pathway:
map00120  Bile acid biosynthesis

# Metabolic_Enzyme_3_Reaction:
A steryl ester + H2O = a sterol + a fatty acid

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF04083:Abhydro_lipase;
PF00561:Abhydrolase_1

# Metabolic_Enzyme_3_Signals:
1-21

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.1.1.13

# Metabolic_Enzyme_3_GenBank_ID_Protein:
187152

# Metabolic_Enzyme_3_SwissProt_ID:
LICH_HUMAN (P38571)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
LIPA

# Metabolic_Enzyme_3_Geneatlas_id:
LIPA

# Metabolic_Enzyme_3_hgnc_id:
HGNC:6617

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_3_Gene_Sequence:
>1200 bp
ATGAAAATGCGGTTCTTGGGGTTGGTGGTCTGTTTGGTTCTCTGGCCCCTGCATTCTGAG
GGGTCTGGAGGGAAACTGACAGCTGTGGATCCTGAAACAAACATGAATGTGAGTGAAATT
ATCTCTTACTGGGGATTCCCTAGTGAGGAATACCTAGTTGAGACAGAAGATGGATATATT
CTGTGCCTTAACCGAATTCCTCATGGGAGGAAGAACCATTCTGACAAAGGTCCCAAACCA
GTTGTCTTCCTGCAACATGGCTTGCTGGCAGATTCTAGTAACTGGGTCACAAACCTTGCC
AACAGCAGCCTGGGCTTCATTCTTGCTGATGCTGGTTTTGACGTGTGGATGGGCAACAGC
AGAGGAAATACCTGGTCTCGGAAACATAAGACACTCTCAGTTTCTCAGGATGAATTCTGG
GCTTTCAGTTATGATGAGATGGCAAAATATGACCTACCAGCTTCCATTAACTTCATTCTG
AATAAAACTGGCCAAGAACAAGTGTATTATGTGGGTCATTCTCAAGGCACCACTATAGGT
TTTATAGCATTTTCACAGATCCCTGAGCTGGCTAAAAGGATTAAAATGTTTTTTGCCCTG
GGTCCTGTGGCTTCCGTCGCCTTCTGTACTAGCCCTATGGCCAAATTAGGACGATTACCA
GATCATCTCATTAAGGACTTATTTGGAGACAAAGAATTTCTTCCCCAGAGTGCGTTTTTG
AAGTGGCTGGGTACCCACGTTTGCACTCATGTCATACTGAAGGAGCTCTGTGGAAATCTC
TGTTTTCTTCTGTGTGGATTTAATGAGAGAAATTTAAATATGTCTAGAGTGGATGTATAT
ACAACACATTCTCCTGCTGGAACTTCTGTGCAAAACATGTTACACTGGAGCCAGGCTGTT
AAATTCCAAAAGTTTCAAGCCTTTGACTGGGGAAGCAGTGCCAAGAATTATTTTCATTAC
AACCAGAGTTATCCTCCCACATACAATGTGAAGGACATGCTTGTGCCGACTGCAGTCTGG
AGCGGGGGTCACGACTGGCTTGCAGATGTCTACGACGTCAATATCTTACTGACTCAGATC
ACCAACTTGGTGTTCCATGAGAGCATTCCGGAATGGGAGCATCTTGACTTCATTTGGGGC
CTGGATGCCCCTTGGAGGCTTTATAATAAAATTATTAATCTAATGAGGAAATATCAGTGA


# Metabolic_Enzyme_3_GenBank_ID_Gene:
M74775

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_3_Locus:
10q23.2-q23.3

# Metabolic_Enzyme_3_SNPs:
rs6586179; rs1051338; rs2250781; rs13500; rs2250644; rs1131706; rs2243548; rs1332328; rs2250398; rs2243547; rs12262734; rs11815435; rs7081622; rs2902561; rs2250645; rs1029074; rs1412444; rs1332329; rs885561; rs2902563; rs1556478; rs2246941; rs12257915; rs2071510; rs2254636; rs2246942; rs11203047; rs12780342; rs10509568; rs2246833; rs2246828; rs3740044; rs928415; rs12246667; rs12267584; rs6586177; rs7908760; rs1029073; rs2246949; rs2071509; rs3802656; rs3892343; rs2071511; rs951647; rs7922269; rs10749600; rs12358054; rs11594137; rs11203041; rs6586178; rs1576818; rs11815364; rs10887934; rs11817360; rs1041390; rs6586175; rs1576817; rs7094730; rs1320496; rs2297472; rs17117526; rs10749601; rs7896502; rs2254747; rs7077817; rs11203046; rs7069914; rs11203042; rs2297475; rs17117789; rs2297473; rs1041389; rs10509569; rs7074555; rs11203043; rs12415827; rs7901936; rs2183934; rs951648; rs7073192; rs869820; rs2297474; rs11813977; rs4509676; rs2183935; rs11817574; rs1930053; rs7097323; rs17117501; rs12359411; rs1412445; rs9651498; rs9651426; rs11203038; rs11818380; rs11203048; rs12240489; rs1041388; rs4554789; rs12255537; rs6586176; rs12782207; rs2254670; rs6586174; rs1332326; rs7912312; rs11818675; rs11812990; rs11813427; rs1332327; rs10887935; rs11203051; rs17850891; rs34719883; rs11203050; rs41284116; rs12255010; rs10535343; rs11203037; rs10535340; rs35673913; rs10612161; rs4934458; rs10535342; rs11311867; rs11203049; rs10535341; rs10677438; rs9664201; rs11538026; rs2902562; rs34138494; rs35762897; rs2863757; rs12777943; rs35942232; rs35516178; rs35127388; rs34088667; rs2254640; rs34003969; rs35146288; rs10600667; rs12246521; rs4415666; rs11414076; rs34068744; rs41284118; rs4531369; rs11388104; rs5786865; rs5786863; rs3831231; rs7922536; rs11203045; rs11594493; rs11203040; rs7478028; rs35472070; rs914606; rs34770706; rs12777942; rs34623250; rs11203039; rs34134835; rs35905319; rs5786864; rs10646193; rs34453649; rs11203044; rs1930052; rs34880741; rs35027333; rs35198481; rs7078593; rs4262635; rs2266006; rs7080543; rs34107465; rs35838114; rs35960932; rs35266008; rs35991075; rs4934457; rs35004751; rs35847941; rs1106211; rs34531458; rs11813627; rs7898142; rs34942702; rs11819292; rs11203052; rs11203036; rs9421714; rs34928929; rs12260368; rs12247969; rs12247966; rs9421715; rs11814022; rs7905685; rs10749599; rs10887931; rs10887932; rs10887936; rs11203031; rs11203032; rs11203033; rs11599741; rs12244855; rs12359655; rs1332325; rs17117124; rs17117126; rs17118228; rs17382301; rs2183933; rs34419176; rs3802658; rs4077998; rs4078488; rs4417181; rs4511206; rs4933497; rs7089138; rs7094601; rs7922193

# Metabolic_Enzyme_3_General_References:
1718995; 8112342; 8725147; 8146180; 9633819

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5751

# Metabolic_Enzyme_4_Name:
Sterol O-acyltransferase 1

# Metabolic_Enzyme_4_Synonyms:
Cholesterol acyltransferase 1; Acyl coenzyme A:cholesterol acyltransferase 1; ACAT-1

# Metabolic_Enzyme_4_Gene_Name:
SOAT1

# Metabolic_Enzyme_4_Protein_Sequence:
>Sterol Oacyltransferase 1
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEE
LKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGK
IFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGK
FPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPT
YVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYF
LFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSAR
VLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTW
NVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFM
FFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVR
PRSWTCRYVF

# Metabolic_Enzyme_4_Number_of_Residues:
550

# Metabolic_Enzyme_4_Molecular_Weight:
64735

# Metabolic_Enzyme_4_Theoretical_pI:
9.18

# Metabolic_Enzyme_4_GO_Classification:
Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase

# Metabolic_Enzyme_4_Pathway:
map00120  Bile acid biosynthesis

# Metabolic_Enzyme_4_Reaction:
acyl-CoA + cholesterol = CoA + cholesterol ester

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF03062:MBOAT

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
141-159
320-341
361-382
470-490
498-518

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.3.1.26

# Metabolic_Enzyme_4_GenBank_ID_Protein:
4878022

# Metabolic_Enzyme_4_SwissProt_ID:
SOAT1_HUMAN (P35610)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
SOAT1

# Metabolic_Enzyme_4_Geneatlas_id:
SOAT1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:11177

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein

# Metabolic_Enzyme_4_Gene_Sequence:
>1653 bp
ATGGTGGGTGAAGAGAAGATGTCTCTAAGAAACCGGCTGTCAAAGTCCAGGGAAAATCCT
GAGGAAGATGAAGACCAGAGAAACCCTGCAAAGGAGTCCCTAGAGACACCTAGTAATGGT
CGAATTGACATAAAACAGTTGATAGCAAAGAAGATAAAGTTGACAGCAGAGGCAGAGGAA
TTGAAGCCATTTTTTATGAAGGAAGTTGGCAGTCACTTTGATGATTTTGTGACCAATCTC
ATTGAAAAGTCAGCATCATTAGATAATGGTGGGTGCGCTCTCACAACCTTTTCTGTTCTT
GAAGGAGAGAAAAACAACCATAGAGCGAAGGATTTGAGAGCACCTCCAGAACAAGGAAAG
ATTTTTATTGCAAGGCGCTCTCTCTTAGATGAACTGCTTGAAGTGGACCACATCAGAACA
ATATATCACATGTTTATTGCCCTCCTCATTCTCTTTATCCTCAGCACACTTGTAGTAGAT
TACATTGATGAAGGAAGGCTGGTGCTTGAGTTCAGCCTCCTGTCTTATGCTTTTGGCAAA
TTTCCTACCGTTGTTTGGACCTGGTGGATCATGTTCCTGTCTACATTTTCAGTTCCCTAT
TTTCTGTTTCAACATTGGGCCACTGGCTATAGCAAGAGTTCTCATCCGCTGATCCGTTCT
CTCTTCCATGGCTTTCTTTTCATGATCTTCCAGATTGGAGTTCTAGGTTTTGGACCAACA
TATGTTGTGTTAGCATATACACTGCCACCAGCTTCCCGGTTCATCATTATATTCGAGCAG
ATTCGTTTTGTAATGAAGGCCCACTCATTTGTCAGAGAGAACGTGCCTCGGGTACTAAAT
TCAGCTAAGGAGAAATCAAGCACTGTTCCAATACCTACAGTCAACCAGTATTTGTACTTC
TTATTTGCTCCTACCCTTATCTACCGTGACAGCTATCCCAGGAATCCCACTGTAAGATGG
GGTTATGTCGCTATGAAGTTTGCACAGGTCTTTGGTTGCTTTTTCTATGTGTACTACATC
TTTGAAAGGCTTTGTGCCCCCTTGTTTCGGAATATCAAACAGGAGCCCTTCAGCGCTCGT
GTTCTGGTCCTATGTGTATTTAACTCCATCTTGCCAGGTGTGCTGATTCTCTTCCTTACT
TTTTTTGCCTTTTTGCACTGCTGGCTCAATGCCTTTGCTGAGATGTTACGCTTTGGTGAC
AGGATGTTCTATAAGGATTGGTGGAACTCCACGTCATACTCCAACTATTATAGAACCTGG
AATGTGGTGGTCCATGACTGGCTATATTACTATGCTTACAAGGACTTTCTCTGGTTTTTC
TCCAAGAGATTCAAATCTGCTGCCATGTTAGCTGTCTTTGCTGTATCTGCTGTAGTACAC
GAATATGCCTTGGCTGTTTGCTTGAGCTTTTTCTATCCCGTGCTCTTCGTGCTCTTCATG
TTCTTTGGAATGGCTTTCAACTTCATTGTCAATGATAGTCGGAAAAAGCCGATTTGGAAT
GTTCTGATGTGGACTTCTCTTTTCTTGGGCAATGGAGTCTTACTCTGCTTTTATTCTCAA
GAATGGTATGCACGTCGGCACTGTCCTCTGAAAAATCCCACATTTTTGGATTATGTCCGG
CCACGTTCCTGGACTTGTCGTTACGTGTTTTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
L21934

# Metabolic_Enzyme_4_Chromosome_Location:
Not Available

# Metabolic_Enzyme_4_Locus:
Not Available

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
8407899; 10438503

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5819

# Metabolic_Enzyme_5_Name:
7-dehydrocholesterol reductase

# Metabolic_Enzyme_5_Synonyms:
7-DHC reductase; Sterol Delta(7-reductase; Putative sterol reductase SR-2

# Metabolic_Enzyme_5_Gene_Name:
DHCR7

# Metabolic_Enzyme_5_Protein_Sequence:
>7dehydrocholesterol reductase
MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL
FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL
ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF

# Metabolic_Enzyme_5_Number_of_Residues:
475

# Metabolic_Enzyme_5_Molecular_Weight:
54490

# Metabolic_Enzyme_5_Theoretical_pI:
8.82

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC)

# Metabolic_Enzyme_5_Pathway:
map00100  Biosynthesis of steroids

# Metabolic_Enzyme_5_Reaction:
cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01222:ERG4_ERG24

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
40-60
154-174
177-197
266-286
306-326
331-351
420-440

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.3.1.21

# Metabolic_Enzyme_5_GenBank_ID_Protein:
4191398

# Metabolic_Enzyme_5_SwissProt_ID:
DHCR7_HUMAN (Q9UBM7)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
DHCR7

# Metabolic_Enzyme_5_Geneatlas_id:
DHCR7

# Metabolic_Enzyme_5_hgnc_id:
HGNC:2860

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein

# Metabolic_Enzyme_5_Gene_Sequence:
>1428 bp
ATGGCTGCAAAATCGCAACCCAACATTCCCAAAGCCAAGAGTCTAGATGGCGTCACCAAT
GACAGAACCGCATCTCAAGGGCAGTGGGGCCGTGCCTGGGAGGTGGACTGGTTTTCACTG
GCGAGCGTCATCTTCCTACTGCTGTTCGCCCCCTTCATCGTCTACTACTTCATCATGGCT
TGTGACCAATACAGCTGCGCCCTGACCGGCCCTGTGGTGGACATCGTCACCGGACATGCT
CGGCTCTCGGACATCTGGGCCAAGACTCCACCTATAACGAGGAAAGCCGCCCAGCTCTAT
ACCTTGTGGGTCACCTTCCAGGTGCTTCTGTACACGTCTCTCCCTGACTTCTGCCATAAG
TTTCTACCCGGCTACGTAGGAGGCATCCAGGAGGGGGCCGTGACTCCTGCAGGGGTTGTG
AACAAGTATCAGATCAACGGCCTGCAAGCCTGGCTCCTCACGCACCTGCTCTGGTTTGCA
AACGCTCATCTCCTGTCCTGGTTCTCGCCCACCATCATCTTCGACAACTGGATCCCACTG
CTGTGGTGCGCCAACATCCTTGGCTATGCCGTCTCCACCTTCGCCATGGTCAAGGGCTAC
TTCTTCCCCACCAGCGCCAGAGACTGCAAATTCACAGGCAATTTCTTTTACAACTACATG
ATGGGCATCGAGTTTAACCCTCGGATCGGGAAGTGGTTTGACTTCAAGCTGTTCTTCAAT
GGGCGCCCCGGGATCGTCGCCTGGACCCTCATCAACCTGTCCTTCGCAGCGAAGCAGCGG
GAGCTCCACAGCCATGTGACCAATGCCATGGTCCTGGTCAACGTCCTGCAGGCCATCTAC
GTGATTGACTTCTTCTGGAACGAAACCTGGTACCTGAAGACCATTGACATCTGCCATGAC
CACTTCGGGTGGTACCTGGGCTGGGGCGACTGTGTCTGGCTGCCTTATCTTTACACGCTG
CAGGGTCTGTACTTGGTGTACCACCCCGTGCAGCTGTCCACCCCGCACGCCGTGGGCGTC
CTGCTGCTGGGCCTGGTGGGCTACTACATCTTCCGGGTGGCCAACCACCAGAAGGACCTG
TTCCGCCGCACGGATGGGCGCTGCCTCATCTGGGGCAGGAAGCCCAAGGTCATCGAGTGC
TCCTACACATCCGCCGACGGGCAGAGGCACCACAGCAAGCTGCTGGTGTCGGGCTTCTGG
GGCGTGGCCCGCCACTTCAACTACGTCGGCGACCTGATGGGCAGCCTGGCCTACTGCCTG
GCCTGTGGCGGTGGCCACCTGCTGCCCTACTTCTACATCATCTACATGGCCATCCTGCTG
ACCCACCGCTGCCTCCGGGACGAGCACCGCTGCGCCAGCAAGTACGGCCGGGACTGGGAG
CGCTACACCGCCGCAGTGCCTTACCGCCTGCTGCCTGGAATCTTCTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AF096305

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_5_Locus:
11q13.2-q13.5

# Metabolic_Enzyme_5_SNPs:
rs760242; rs12577137; rs1790334; rs1044482; rs949177; rs760241; rs4316537; rs909217; rs1790345; rs1044535; rs3750997; rs12573951; rs10450661; rs7690; rs1790324; rs736894; rs1790328; rs1790330; rs1792268; rs17161531; rs1790327; rs1790329; rs1630498; rs949176; rs1792264; rs2852853; rs11603330; rs2851693; rs11606033; rs1790325; rs1792265; rs1790326; rs10898144; rs12422045; rs1792270; rs1790348; rs7122671; rs1790346; rs4944949; rs28364617; rs7928249; rs10450662; rs1790347; rs4944946; rs11555217; rs1127869; rs28939698; rs12800; rs35946774; rs11233662; rs34258235; rs5792560; rs1802126; rs34995793; rs12407; rs7950991; rs11233706; rs34541828; rs34240558; rs1802125; rs11555218; rs35616583; rs12271811; rs1802378; rs34463022; rs35826756; rs2852855; rs28364772; rs12281087; rs34405099; rs2851692; rs12294879; rs2852857; rs2852850; rs12283656; rs12285189; rs760238; rs2852849; rs2852858; rs760240; rs1790331; rs1792223; rs1792267; rs2852851; rs2852854; rs5792559; rs34177783; rs11233679; rs2852856; rs760239; rs1790332; rs2851691; rs28364773; rs2852852; rs35589965; rs11233713; rs35649052; rs28364616; rs11546508; rs34809983; rs7944310; rs12804192; rs11366361; rs12270619; rs12272475; rs12280295; rs12285168; rs12285333; rs12419279; rs12419334; rs12785878; rs12797951; rs1623080; rs1629055; rs1790349; rs1790351; rs1790352; rs1790353; rs1790373; rs1792271; rs1792272; rs1792273; rs1792275; rs1792276; rs1792277; rs1792278; rs1792279; rs1792316; rs2002063; rs2002064; rs3184354; rs4944955; rs4944956; rs4944957; rs4944958; rs4944959; rs7944926

# Metabolic_Enzyme_5_General_References:
9683613; 9465114; 9878250; 9634533; 9653161; 10677299; 10995508; 11175299; 12949967

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5473

# Metabolic_Enzyme_6_Name:
Bile salt-activated lipase precursor

# Metabolic_Enzyme_6_Synonyms:
BAL; Bile salt-stimulated lipase; BSSL; Carboxyl ester lipase; Sterol esterase; Cholesterol esterase; Pancreatic lysophospholipase

# Metabolic_Enzyme_6_Gene_Name:
CEL

# Metabolic_Enzyme_6_Protein_Sequence:
>Bile saltactivated lipase precursor
MGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTK
ALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPV
MIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPG
NYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQS
GVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAGLEYP
MLHYVGFVPVIDGDFIPADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVT
EEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIA
LAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTV
SKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLR
YWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSG
APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP
PTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDS
EAAPVPPTDDSKEAQMPAVIRF

# Metabolic_Enzyme_6_Number_of_Residues:
742

# Metabolic_Enzyme_6_Molecular_Weight:
78346

# Metabolic_Enzyme_6_Theoretical_pI:
5.01

# Metabolic_Enzyme_6_GO_Classification:
Not Available

# Metabolic_Enzyme_6_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides

# Metabolic_Enzyme_6_Pathway:
map00120  Bile acid biosynthesis

# Metabolic_Enzyme_6_Reaction:
A steryl ester + H2O = a sterol + a fatty acid

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00135:COesterase

# Metabolic_Enzyme_6_Signals:
1-20

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.1.1.3;EC 3.1.1.13

# Metabolic_Enzyme_6_GenBank_ID_Protein:
29501

# Metabolic_Enzyme_6_SwissProt_ID:
CEL_HUMAN (P19835)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
CEL

# Metabolic_Enzyme_6_Geneatlas_id:
CEL

# Metabolic_Enzyme_6_hgnc_id:
HGNC:1848

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>2238 bp
ATGCTCACCATGGGGCGCCTGCAACTGGTTGTGTTGGGCCTCACCTGCTGCTGGGCAGTG
GCGAGTGCCGCGAAGCTGGGCGCCGTGTACACAGAAGGTGGGTTCGTGGAAGGCGTCAAT
AAGAAGCTCGGCCTCCTGGGTGACTCTGTGGACATCTTCAAGGGCATCCCCTTCGCAGCT
CCCACCAAGGCCCTGGAAAATCCTCAGCCACATCCTGGCTGGCAAGGGACCCTGAAGGCC
AAGAACTTCAAGAAGAGATGCCTGCAGGCCACCATCACCCAGGACAGCACCTACGGGGAT
GAAGACTGCCTGTACCTCAACATTTGGGTGCCCCAGGGCAGGAAGCAAGTCTCCCGGGAC
CTGCCCGTTATGATCTGGATCTATGGAGGCGCCTTCCTCATGGGGTCCGGCCATGGGGCC
AACTTCCTCAACAACTACCTGTATGACGGCGAGGAGATCGCCACACGCGGAAACGTCATC
GTGGTCACCTTCAACTACCGTGTCGGCCCCCTTGGGTTCCTCAGCACTGGGGACGCCAAT
CTGCCAGGTAACTATGGCCTTCGGGATCAGCACATGGCCATTGCTTGGGTGAAGAGGAAT
ATCGCGGCCTTCGGGGGGGACCCCAACAACATCACGCTCTTCGGGGAGTCTGCTGGAGGT
GCCAGCGTCTCTCTGCAGACCCTCTCCCCCTACAACAAGGGCCTCATCCGGCGAGCCATC
AGCCAGAGCGGCGTGGCCCTGAGTCCCTGGGTCATCCAGAAAAACCCACTCTTCTGGGCC
AAAAAGGTGGCTGAGAAGGTGGGTTGCCCTGTGGGTGATGCCGCCAGGATGGCCCAGTGT
CTGAAGGTTACTGATCCCCGAGCCCTGACGCTGGCCTATAAGGTGCCGCTGGCAGGCCTG
GAGTACCCCATGCTGCACTATGTGGGCTTCGTCCCTGTCATTGATGGAGACTTCATCCCC
GCTGACCCGATCAACCTGTACGCCAACGCCGCCGACATCGACTATATAGCAGGCACCAAC
AACATGGACGGCCACATCTTCGCCAGCATCGACATGCCTGCCATCAACAAGGGCAACAAG
AAAGTCACGGAGGAGGACTTCTACAAGCTGGTCAGTGAGTTCACAATCACCAAGGGGCTC
AGAGGCGCCAAGACGACCTTTGATGTCTACACCGAGTCCTGGGCCCAGGACCCATCCCAG
GAGAATAAGAAGAAGACTGTGGTGGACTTTGAGACCGATGTCCTCTTCCTGGTGCCCACC
GAGATTGCCCTAGCCCAGCACAGAGCCAATGCCAAGAGTGCCAAGACCTACGCCTACCTG
TTTTCCCATCCCTCTCGGATGCCCGTCTACCCCAAATGGGTGGGGGCCGACCATGCAGAT
GACATTCAGTACGTTTTCGGGAAGCCCTTCGCCACCCCCACGGGCTACCGGCCCCAAGAC
AGGACAGTCTCTAAGGCCATGATCGCCTACTGGACCAACTTTGCCAAAACAGGGGACCCC
AACATGGGCGACTCGGCTGTGCCCACACACTGGGAACCCTACACTACGGAAAACAGCGGC
TACCTGGAGATCACCAAGAAGATGGGCAGCAGCTCCATGAAGCGGAGCCTGAGAACCAAC
TTCCTGCGCTACTGGACCCTCACCTATCTGGCGCTGCCCACAGTGACCGACCAGGAGGCC
ACCCCTGTGCCCCCCACAGGGGACTCCGAGGCCACTCCCGTGCCCCCCACGGGTGACTCC
GAGACCGCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCCCCCGTGCCGCCCACGGGT
GACTCCGGGGCCCCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCCCCCGTGCCGCCC
ACGGGTGACTCCGGGGCCCCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCCCCCGTG
CCGCCCACGGGTGACTCCGGGGCCCCCCCCGTGCCGCCCACGGGTGACTCCGGCGCCCCC
CCCGTGCCGCCCACGGGTGACGCCGGGCCCCCCCCCGTGCCGCCCACGGGTGACTCCGGC
GCCCCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCCCCCGTGACCCCCACGGGTGAC
TCCGAGACCGCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCCCCTGTGCCCCCCACG
GGTGACTCTGAGGCTGCCCCTGTGCCCCCCACAGATGACTCCAAGGAAGCTCAGATGCCT
GCAGTCATTAGGTTTTAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
X54457

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_6_Locus:
9q34.3

# Metabolic_Enzyme_6_SNPs:
rs2013751; rs592267; rs8193020; rs657740; rs668809; rs658107; rs657747; rs674908; rs1734945; rs9328542; rs35169970; rs2480920; rs34800980; rs2480922; rs35939167; rs490954; rs657704; rs2480921; rs11552537; rs13287310; rs13283110; rs2480923; rs488087; rs657617; rs35171271; rs2257704; rs598333; rs8193023; rs640509; rs2013695; rs1318508; rs2855061; rs11243990; rs12341761; rs915953; rs35064121; rs2855063; rs2855064; rs2855057; rs2773809; rs12351505; rs11243989; rs2855059; rs36126424; rs11355299; rs8193019; rs7851444; rs644166; rs2855062; rs915950; rs34365056; rs2855056; rs687763; rs34519053; rs34646804; rs11243991; rs2855058; rs640507; rs2855055; rs12344494; rs2855049; rs600825; rs2855066; rs11243988; rs470512; rs2855060; rs2905087; rs2855053; rs12001261; rs2855050; rs12001694; rs674510; rs642440; rs2855054; rs2855052; rs13296252; rs2001000; rs34064957; rs10121942; rs1047780; rs11792806; rs12236821; rs17150138; rs2073821; rs2283134; rs28758507; rs35181097; rs491904; rs509064; rs526855; rs534629; rs563864; rs586977; rs590504; rs607809; rs637435; rs640720; rs645736; rs645841; rs6597598; rs685959; rs7021286; rs7044003; rs7324; rs7852868; rs7863758; rs8193017

# Metabolic_Enzyme_6_General_References:
1698625; 2265692; 1988041; 1639390; 7578248; 1991511; 7654718; 10024660; 11045623

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5998

# Metabolic_Enzyme_7_Name:
Cytochrome P450 11A1, mitochondrial precursor

# Metabolic_Enzyme_7_Synonyms:
CYPXIA1; P450(scc; Cholesterol side-chain cleavage enzyme; Cholesterol desmolase

# Metabolic_Enzyme_7_Gene_Name:
CYP11A1

# Metabolic_Enzyme_7_Protein_Sequence:
>Cytochrome P450 11A1, mitochondrial precursor
MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWL
NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPER
FLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVS
VLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQM
FHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRG
ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR
HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIY
ALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML
ENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ

# Metabolic_Enzyme_7_Number_of_Residues:
521

# Metabolic_Enzyme_7_Molecular_Weight:
60103

# Metabolic_Enzyme_7_Theoretical_pI:
9.18

# Metabolic_Enzyme_7_GO_Classification:
Not Available

# Metabolic_Enzyme_7_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_7_Specific_Function:
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone

# Metabolic_Enzyme_7_Pathway:
map00140  C21-Steroid hormone metabolism

# Metabolic_Enzyme_7_Reaction:
cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_7_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.14.15.6

# Metabolic_Enzyme_7_GenBank_ID_Protein:
181376

# Metabolic_Enzyme_7_SwissProt_ID:
CP11A_HUMAN (P05108)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
CYP11A1

# Metabolic_Enzyme_7_Geneatlas_id:
CYP11A1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:2590

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_7_Gene_Sequence:
>1566 bp
ATGCTGGCCAAGGGTCTTCCCCCACGCTCAGTCCTGGTCAAAGGCTACCAGACCTTTCTG
AGTGCCCCCAGGGAGGGGCTGGGGCGTCTCAGGGTGCCCACTGGCGAGGGAGCTGGCATC
TCCACCCGCAGTCCTCGCCCCTTCAATGAGATCCCCTCTCCTGGTGACAATGGCTGGCTA
AACCTGTACCATTTCTGGAGGGAGACGGGCACACACAAAGTCCACCTTCACCATGTCCAG
AATTTCCAGAAGTATGGCCCGATTTACAGGGAGAAGCTCGGCAACGTGGAGTCGGTTTAT
GTCATCGACCCTGAAGATGTGGCCCTTCTCTTTAAGTCCGAGGGCCCCAACCCAGAACGA
TTCCTCATCCCGCCCTGGGTCGCCTATCACCAGTATTACCAGAGACCCATAGGAGTCCTG
TTGAAGAAGTCGGCAGCCTGGAAGAAAGACCGGGTGGCCCTGAACCAGGAGGTGATGGCT
CCAGAGGCCACCAAGAACTTTTTGCCCCTGTTGGATGCAGTGTCTCGGGACTTCGTCAGT
GTCCTGCACAGGCGCATCAAGAAGGCGGGCTCCGGAAATTACTCGGGGGACATCAGTGAT
GACCTGTTCCGCTTTGCCTTTGAGTCCATCACTAACGTCATTTTTGGGGAGCGCCAGGGG
ATGCTGGAGGAAGTAGTGAACCCCGAGGCCCAGCGATTCATTGATGCCATCTACCAGATG
TTCCACACCAGCGTCCCCATGCTCAACCTTCCCCCAGACCTGTTCCGTCTGTTCAGGACC
AAGACCTGGAAGGACCATGTGGCTGCATGGGACGTGATTTTCAGTAAAGCTGACATATAC
ACCCAGAACTTCTACTGGGAATTGAGACAGAAAGGAAGTGTTCACCACGATTACCGTGGC
ATGCTCTACAGACTCCTGGGAGACAGCAAGATGTCCTTCGAGGACATCAAGGCCAACGTC
ACAGAGATGCTGGCAGGAGGGGTGGACACGACGTCCATGACCCTGCAGTGGCACTTGTAT
GAGATGGCACGCAACCTGAAGGTGCAGGATATGCTGCGGGCAGAGGTCTTGGCTGCGCGG
CACCAGGCCCAGGGAGACATGGCCACGATGCTACAGCTGGTCCCCCTCCTCAAAGCCAGC
ATCAAGGAGACACTAAGACTTCACCCCATCTCCGTGACCCTGCAGAGATATCTTGTAAAT
GACTTGGTTCTTCGAGATTACATGATTCCTGCCAAGACACTGGTGCAAGTGGCCATCTAT
GCTCTGGGCCGAGAGCCCACCTTCTTCTTCGACCCGGAAAATTTTGACCCAACCCGATGG
CTGAGCAAAGACAAGAACATCACCTACTTCCGGAACTTGGGCTTTGGCTGGGGTGTGCGG
CAGTGTCTGGGACGGCGGATCGCTGAGCTAGAGATGACCATCTTCCTCATCAATATGCTG
GAGAACTTCAGAGTTGAAATCCAACACCTCAGCGATGTGGGCACCACATTCAACCTCATT
CTGATGCCTGAAAAGCCCATCTCCTTCACCTTCTGGCCCTTTAACCAGGAAGCAACCCAG
CAGTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
M14565

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_7_Locus:
15q23-q24

# Metabolic_Enzyme_7_SNPs:
rs6161; rs6160; rs4986873; rs2279357; rs1484215; rs11632698; rs11638442; rs12916123; rs4886594; rs1843090; rs6495096; rs41548820; rs7175214; rs2930299; rs41563614; rs41553712; rs17515476; rs12898858; rs12917295; rs2959021; rs41553612; rs41556119; rs7173655; rs7181332; rs900798; rs2073475; rs4887139; rs1049968; rs1130843; rs11544450; rs1130841; rs1132670; rs35048801; rs28671731; rs41543514; rs35153064; rs7177102; rs34371865; rs41556118; rs4887138; rs34304260; rs41543216; rs2930307; rs35856463; rs41546519; rs28681535; rs34637683; rs12442401; rs11350546; rs4640133; rs2959020; rs41550215; rs34223131; rs10635828; rs36133203; rs10644492; rs10645960; rs3831490; rs34886193; rs17522870; rs11633031; rs11635047; rs12438594; rs12899286; rs12899703; rs12900028; rs12917557; rs1564782; rs16968477; rs16968478; rs2170875; rs2277601; rs2277602; rs2277603; rs2277604; rs2277605; rs2277606; rs2279356; rs2930305; rs2930306; rs2959002; rs2959003; rs2959004; rs3803463; rs3825944; rs4077581; rs4077582; rs4077583; rs4077584; rs4077585; rs4278698; rs4432229; rs4886595; rs4887136; rs4887137; rs7163952; rs7164328; rs7174179; rs8031424; rs8034118; rs8039957; rs900802; rs9806234

# Metabolic_Enzyme_7_General_References:
3024157; 3038854; 1849407; 2419119; 10391209; 11502818; 12161514

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
8578

# Metabolic_Enzyme_8_Name:
Cholesterol 25-hydroxylase

# Metabolic_Enzyme_8_Synonyms:
Cholesterol 25- monooxygenase; h25OH

# Metabolic_Enzyme_8_Gene_Name:
CH25H

# Metabolic_Enzyme_8_Protein_Sequence:
>Cholesterol 25hydroxylase
MSCHNCSDPQVLCSSGQLFLQPLWDHLRSWEALLQSPFFPVIFSITTYVGFCLPFVVLDI
LCSWVPALRRYKIHPDFSPSAQQLLPCLGQTLYQHVMFVFPVTLLHWARSPALLPHEAPE
LLLLLHHILFCLLLFDMEFFVWHLLHHKVPWLYRTFHKVHHQNSSSFALATQYMSVWELF
SLGFFDMMNVTLLGCHPLTTLTFHVVNIWLSVEDHSGYNFPWSTHRLVPFGWYGGVVHHD
LHHSHFNCNFAPYFTHWDKILGTLRTASVPAR

# Metabolic_Enzyme_8_Number_of_Residues:
272

# Metabolic_Enzyme_8_Molecular_Weight:
31745

# Metabolic_Enzyme_8_Theoretical_pI:
7.26

# Metabolic_Enzyme_8_GO_Classification:
>>>
 Function:  catalytic activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Lipid transport and metabolism

# Metabolic_Enzyme_8_Specific_Function:
Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation

# Metabolic_Enzyme_8_Pathway:
Not Available

# Metabolic_Enzyme_8_Reaction:
Not Available

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF01598:Sterol_desat

# Metabolic_Enzyme_8_Signals:
Not Available

# Metabolic_Enzyme_8_Transmembrane_Regions:
38-58
84-104
121-141

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.14.99.38

# Metabolic_Enzyme_8_GenBank_ID_Protein:
4038304

# Metabolic_Enzyme_8_SwissProt_ID:
CH25H_HUMAN (O95992)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
CH25H

# Metabolic_Enzyme_8_Geneatlas_id:
CH25H

# Metabolic_Enzyme_8_hgnc_id:
HGNC:1907

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein

# Metabolic_Enzyme_8_Gene_Sequence:
>819 bp
ATGAGCTGCCACAACTGCTCCGACCCCCAGGTCCTTTGCAGCTCCGGGCAGCTGTTCCTG
CAGCCCCTCTGGGACCACCTGAGGAGCTGGGAGGCCCTCCTACAGTCGCCCTTCTTCCCG
GTCATCTTCTCCATCACCACATACGTGGGCTTTTGCCTGCCCTTCGTGGTCCTGGATATC
CTGTGCTCCTGGGTGCCCGCCCTGCGGCGCTACAAGATCCACCCTGACTTCTCGCCATCC
GCGCAGCAGCTGCTACCTTGCCTGGGGCAGACCCTCTACCAGCATGTGATGTTTGTGTTC
CCCGTGACGCTGCTGCATTGGGCCCGCAGCCCGGCCCTCCTGCCCCACGAAGCTCCCGAG
CTGCTCCTGCTGCTGCACCACATCCTGTTCTGCCTGCTACTCTTCGACATGGAGTTCTTC
GTGTGGCACCTGCTGCACCACAAGGTGCCCTGGCTGTACCGCACCTTCCACAAGGTGCAC
CACCAGAACTCGTCCTCGTTCGCGCTGGCAACGCAGTATATGAGCGTCTGGGAACTGTTT
TCTTTGGGCTTCTTCGACATGATGAACGTCACACTGCTCGGGTGCCACCCGCTCACCACC
CTGACCTTCCACGTGGTCAACATCTGGCTTTCCGTGGAGGACCACTCCGGCTACAACTTC
CCTTGGTCCACTCACAGACTGGTGCCCTTCGGGTGGTACGGGGGTGTGGTGCACCACGAC
CTGCATCACTCTCACTTTAACTGCAACTTCGCTCCGTACTTTACACACTGGGACAAAATA
CTGGGAACGCTGCGGACTGCATCTGTCCCAGCGCGGTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
AF059212

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_8_Locus:
10q23

# Metabolic_Enzyme_8_SNPs:
rs17382301; rs4078488; rs10887932; rs3802657; rs3802658; rs4077998; rs4417181; rs10887931; rs11203033; rs10749599; rs11203032; rs4933497; rs17117126; rs11203031; rs11203030; rs17117124; rs12244855; rs17117295; rs12243890; rs41284114; rs4511206; rs5786862; rs35104206; rs35094242; rs36032382; rs5786861; rs12247047; rs11203037; rs1131706; rs11591995; rs11594137; rs11812990; rs11813427; rs11817449; rs11818675; rs12245538; rs12246667; rs12258737; rs12265079; rs13500; rs17117088; rs34419176; rs3802656; rs4073283; rs4074851; rs4509676; rs4934455; rs4934456; rs7089138; rs7091822; rs7098394; rs7896695; rs7912312; rs9664201

# Metabolic_Enzyme_8_General_References:
9852097

# Metabolic_Enzyme_8_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
6941

# Macromolecular_Interacting_Partner_1_Name:
ATP-binding cassette sub-family A member 1

# Macromolecular_Interacting_Partner_1_Synonyms:
ATP-binding cassette transporter 1; ATP-binding cassette 1; ABC-1; Cholesterol efflux regulatory protein

# Macromolecular_Interacting_Partner_1_Gene_Name:
ABCA1

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>ATPbinding cassette subfamily A member 1
MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKA
MPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDT
SMKDMRKVLRTLQQIKKSSSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRADVILH
KVFLQGYQLHLTSLCNGSKSEEMIQLGDQEVSELCGLPREKLAAAERVLRSNMDILKPIL
RTLNSTSPFPSKELAEATKTLLHSLGTLAQELFSMRSWSDMRQEVMFLTNVNSSSSSTQI
YQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETFYDNSTTPYCNDLMK
NLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELS
PKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQSSNGS
VYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMELLDERKFWAGIVFTG
ITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVV
EQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIV
YEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFV
FLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFAS
LLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTW
YIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVS
IQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYIL
GKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVG
LPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQ
GRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLS
SCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDI
GHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAE
TSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVK
GWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQ
PWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAP
VPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDL
TGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDATKQMKK
HLKLAKDSSADRFLNSLGRFMTGLDTRNNVKVWFNNKGWHAISSFLNVINNAILRANLQK
GENPSHYGITAFNHPLNLTKQQLSEVAPMTTSVDVLVSICVIFAMSFVPASFVVFLIQER
VSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLAL
LLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNNIN
DILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEG
VVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKELTKI
YRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSN
IHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEK
YAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLT
SHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFG
LAFPGSVPKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNF
AKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
2261

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
254289

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.84

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_1_Specific_Function:
cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
22-42
640-660
683-703
716-736
745-765
777-797
827-847
1041-1057
1351-1371
1657-1677
1703-1723
1735-1755
1768-1788
1802-1822
1852-1872

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
9247086

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
ABCA1_HUMAN (O95477)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
ABCA1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
ABCA1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:29

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>6786 bp
ATGGCTTGTTGGCCTCAGCTGAGGTTGCTGCTGTGGAAGAACCTCACTTTCAGAAGAAGA
CAAACATGTCAGCTGCTGCTGGAAGTGGCCTGGCCTCTATTTATCTTCCTGATCCTGATC
TCTGTTCGGCTGAGCTACCCACCCTATGAACAACATGAATGCCATTTTCCAAATAAAGCC
ATGCCCTCTGCAGGAACACTTCCTTGGGTTCAGGGGATTATCTGTAATGCCAACAACCCC
TGTTTCCGTTACCCGACTCCTGGGGAGGCTCCCGGAGTTGTTGGAAACTTTAACAAATCC
ATTGTGGCTCGCCTGTTCTCAGATGCTCGGAGGCTTCTTTTATACAGCCAGAAAGACACC
AGCATGAAGGACATGCGCAAAGTTCTGAGAACATTACAGCAGATCAAGAAATCCAGCTCA
AACTTGAAGCTTCAAGATTTCCTGGTGGACAATGAAACCTTCTCTGGGTTCCTGTATCAC
AACCTCTCTCTCCCAAAGTCTACTGTGGACAAGATGCTGAGGGCTGATGTCATTCTCCAC
AAGGTATTTTTGCAAGGCTACCAGTTACATTTGACAAGTCTGTGCAATGGATCAAAATCA
GAAGAGATGATTCAACTTGGTGACCAAGAAGTTTCTGAGCTTTGTGGCCTACCAAGGGAG
AAACTGGCTGCAGCAGAGCGAGTACTTCGTTCCAACATGGACATCCTGAAGCCAATCCTG
AGAACACTAAACTCTACATCTCCCTTCCCGAGCAAGGAGCTGGCYGAAGCCACAAAAACA
TTGCTGCATAGTCTTGGGACTCTGGCCCAGGAGCTGTTCAGCATGAGAAGCTGGAGTGAC
ATGCGACAGGAGGTGATGTTTCTGACCAATGTGAACAGCTCCAGCTCCTCCACCCAAATC
TACCAGGCTGTGTCTCGTATTGTCTGCGGGCATCCCGAGGGAGGGGGGCTGAAGATCAAG
TCTCTCAACTGGTATGAGGACAACAACTACAAAGCCCTCTTTGGAGGCAATGGCACTGAG
GAAGATGCTGAAACCTTCTATGACAACTCTACAACTCCTTACTGCAATGATTTGATGAAG
AATTTGGAGTCTAGTCCTCTTTCCCGCATTATCTGGAAAGCTCTGAAGCCGCTGCTCGTT
GGGAAGATCCTGTATACACCTGACACTCCAGCCACAAGGCAGGTCATGGCTGAGGTGAAC
AAGACCTTCCAGGAACTGGCTGTGTTCCATGATCTGGAAGGCATGTGGGAGGAACTCAGC
CCCAAGATCTGGACCTTCATGGAGAACAGCCAAGAAATGGACCTTGTCCGGATGCTGTTG
GACAGCAGGGACAATGACCACTTTTGGGAACAGCAGTTGGATGGCTTAGATTGGACAGCC
CAAGACATCGTGGCGTTTTTGGCCAAGCACCCAGAGGATGTCCAGTCCAGTAATGGTTCT
GTGTACACCTGGAGAGAAGCTTTCAACGAGACTAACCAGGCAATCCGGACCATATCTCGC
TTCATGGAGTGTGTCAACCTGAACAAGCTAGAACCCATAGCAACAGAAGTCTGGCTCATC
AACAAGTCCATGGAGCTGCTGGATGAGAGGAAGTTCTGGGCTGGTATTGTGTTCACTGGA
ATTACTCCAGGCAGCATTGAGCTGCCCCATCATGTCAAGTACAAGATCCGAATGGACATT
GACAATGTGGAGAGGACAAATAAAATCAAGGATGGGTACTGGGACCCTGGTCCTCGAGCT
GACCCCTTTGAGGACATGCGGTACGTCTGGGGGGGCTTCGCCTACTTGCAGGATGTGGTG
GAGCAGGCAATCATCAGGGTGCTGACGGGCACCGAGAAGAAAACTGGTGTCTATATGCAA
CAGATGCCCTATCCCTGTTACGTTGATGACATCTTTCTGCGGGTGATGAGCCGGTCAATG
CCCCTCTTCATGACGCTGGCCTGGATTTACTCAGTGGCTGTGATCATCAAGGGCATCGTG
TATGAGAAGGAGGCACGGCTGAAAGAGACCATGCGGATCATGGGCCTGGACAACAGCATC
CTCTGGTTTAGCTGGTTCATTAGTAGCCTCATTCCTCTTCTTGTGAGCGCTGGCCTGCTA
GTGGTCATCCTGAAGTTAGGAAACCTGCTGCCCTACAGTGATCCCAGCGTGGTGTTTGTC
TTCCTGTCCGTGTTTGCTGTGGTGACAATCCTGCAGTGCTTCCTGATTAGCACACTCTTC
TCCAGAGCCAACCTGGCAGCAGCCTGTGGGGGCATCATCTACTTCACGCTGTACCTGCCC
TACGTCCTGTGTGTGGCATGGCAGGACTACGTGGGCTTCACACTCAAGATCTTCGCTARC
CTGCTGTCTCCTGTGGCTTTTGGGTTTGGCTGTGAGTACTTTGCCCTTTTTGAGGAGCAG
GGCATTGGAGTGCAGTGGGACAACCTGTTTGAGAGTCCTGTGGAGGAAGATGGCTTCAAT
CTCACCACTTCGGTCTCCATGATGCTGTTTGACACCTTCCTCTATGGGGTGATGACCTGG
TACATTGAGGCTGTCTTTCCAGGCCAGTACGGAATTCCCAGGCCCTGGTATTTTCCTTGC
ACCAAGTCCTACTGGTTTGGCGAGGAAAGTGATGAGAAGAGCCACCCTGGTTCCAACCAG
AAGAGAATATCAGAAATCTGCATGGAGGAGGAACCCACCCACTTGAAGCTGGGCGTGTCC
ATTCAGAACCTGGTAAAAGTCTACCGAGATGGGATGAAGGTGGCTGTCGATGGCCTGGCA
CTGAATTTTTATGAGGGCCAGATCACCTCCTTCCTGGGCCACAATGGAGCGGGGAAGACG
ACCACCATGTCAATCCTGACCGGGTTGTTCCCCCCGACCTCGGGCACCGCCTACATCCTG
GGAAAAGACATTCGCTCTGAGATGAGCACCATCCGGCAGAACCTGGGGGTCTGTCCCCAG
CATAACGTGCTGTTTGACATGCTGACTGTCGAAGAACACATCTGGTTCTATGCCCGCTTG
AAAGGGCTCTCTGAGAAGCACGTGAAGGCGGAGATGGAGCAGATGGCCCTGGATGTTGGT
TTGCCATCAAGCAAGCTGAAAAGCAAAACAAGCCAGCTGTCAGGTGGAATGCAGAGAAAG
CTATCTGTGGCCTTGGCCTTTGTCGGGGGATCTAAGGTTGTCATTCTGGATGAACCCACA
GCTGGTGTGGACCCTTACTCCCGCAGGGGAATATGGGAGCTGCTGCTGAAATACCGACAA
GGCCGCACCATTATTCTCTCTACACACCACATGGATGAAGCGGACGTCCTGGGGGACAGG
ATTGCCATCATCTCCCATGGGAAGCTGTGCTGTGTGGGCTCCTCCCTGTTTCTGAAGAAC
CAGCTGGGAACAGGCTACTACCTGACCTTGGTCAAGAAAGATGTGGAATCCTCCCTCAGT
TCCTGCAGAAACAGTAGTAGCACTGTGTCATACCTGAAAAAGGAGGACAGTGTTTCTCAG
AGCAGTTCTGATGCTGGCCTGGGCAGCGACCATGAGAGTGACACGCTGACCATCGATGTC
TCTGCTATCTCCAACCTCATCAGGAAGCATGTGTCTGAAGCCCGGCTGGTGGAAGACATA
GGGCATGAGCTGACCTATGTGCTGCCATATGAAGCTGCTAAGGAGGGAGCCTTTGTGGAA
CTCTTTCATGAGATTGATGACCGGCTCTCAGACCTGGGCATTTCTAGTTATGGCATCTCA
GAGACGACCCTGGAAGAAATATTCCTCAAGGTGGCCGAAGAGAGTGGGGTGGATGCTGAG
ACCTCAGATGGTACCTTGCCAGCAAGACGAAACAGGCGGGCCTTCGGGGACAAGCAGAGC
TGTCTTCGCCCGTTCACTGAAGATGATGCTGCTGATCCAAATGATTCTGACATAGACCCA
GAATCCAGAGAGACAGACTTGCTCAGTGGGATGGATGGCAAAGGGTCCTACCAGGTGAAA
GGCTGGAAACTTACACAGCAACAGTTTGTGGCCCTTTTGTGGAAGAGACTGCTAATTGCC
AGACGGAGTCGGAAAGGATTTTTTGCTCAGATTGTCTTGCCAGCTGTGTTTGTCTGCATT
GCCCTTGTGTTCAGCCTGATCGTGCCACCCTTTGGCAAGTACCCCAGCCTGGAACTTCAG
CCCTGGATGTACAACGAACAGTACACATTTGTCAGCAATGATGCTCCTGAGGACACGGGA
ACCCTGGAACTCTTAAACGCCCTCACCAAAGACCCTGGCTTCGGGACCCGCTGTATGGAA
GGAAACCCAATCCCAGACACGCCCTGCCAGGCAGGGGAGGAAGAGTGGACCACTGCCCCA
GTTCCCCAGACCATCATGGACCTCTTCCAGAATGGGAACTGGACAATGCAGAACCCTTCA
CCTGCATGCCAGTGTAGCAGCGACAAAATCAAGAAGATGCTGCCTGTGTGTCCCCCAGGG
GCAGGGGGGCTGCCTCCTCCACAAAGAAAACAAAACACTGCAGATATCCTTCAGGACCTG
ACAGGAAGAAACATTTCGGATTATCTGGTGAAGACGTATGTGCAGATCATAGCCAAAAGC
TTAAAGAACAAGATCTGGGTGAATGAGTTTAGGTATGGCGGCTTTTCCCTGGGTGTCAGT
AATACTCAAGCACTTCCTCCGAGTCAAGAAGTTAATGATGCCAYCAAACAAATGAAGAAA
CACCTAAAGCTGGCCAAGGACAGTTCTGCAGATCGATTTCTCAACAGCTTGGGAAGATTT
ATGACAGGACTGGACACCAGAAATAATGTCAAGGTGTGGTTCAATAACAAGGGCTGGCAT
GCAATCAGCTCTTTCCTGAATGTCATCAACAATGCCATTCTCCGGGCCAACCTGCAAAAG
GGAGAGAACCCTAGCCATTATGGAATTACTGCTTTCAATCATCCCCTGAATCTCACCAAG
CAGCAGCTCTCAGAGGTGGCTCYGATGACCACATCAGTGGATGTCCTTGTGTCCATCTGT
GTCATCTTTGCAATGTCCTTCGTCCCAGCCAGCTTTGTCGTATTCCTGATCCAGGAGCGG
GTCAGCAAAGCAAAACACCTGCAGTTCATCAGTGGAGTGAAGCCTGTCATCTACTGGCTC
TCTAATTTTGTCTGGGATATGTGCAATTACGTTGTCCCTGCCACACTGGTCATTATCATC
TTCATCTGCTTCCAGCAGAAGTCCTATGTGTCCTCCACCAATCTGCCTGTGCTAGCCCTT
CTACTTTTGCTGTATGGGTGGTCAATCACACCTCTCATGTACCCAGCCTCCTTTGTGTTC
AAGATCCCCAGCACAGCCTATGTGGTGCTCACCAGCGTGAACCTCTTCATTGGCATTAAT
GGCAGCGTGGCCACCTTTGTGCTGGAGCTGTTCACCGACAATAAGCTGAATAATATCAAT
GATATCCTGAAGTCCGTGTTCTTGATCTTCCCACATTTTTGCCTGGGACGAGGGCTCATC
GACATGGTGAAAAACCAGGCAATGGCTGATGCCCTGGAAAGGTTTGGGGAGAATCGCTTT
GTGTCACCATTATCTTGGGACTTGGTGGGACGAAACCTCTTCGCCATGGCCGTGGAAGGG
GTGGTGTTCTTCCTCATTACTGTTCTGATCCAGTACAGATTCTTCATCAGGCCCAGACCT
GTAAATGCAAAGCTATCTCCTCTGAATGATGAAGATGAAGATGTGAGGCGGGAAAGACAG
AGAATTCTTGATGGTGGAGGCCAGAATGACATCTTAGAAATCAAGGAGTTGACGAAGATA
TATAGAAGGAAGCGGAAGCCTGCTGTTGACAGGATTTGCGTGGGCATTCCTCCTGGTGAG
TGCTTTGGGCTCCTGGGAGTTAATGGGGCTGGAAAATCATCAACTTTCAAGATGTTAACA
GGAGATACCACTGTTACCAGAGGAGATGCTTTCCTTAACARAAATAGTATCTTATCAAAC
ATCCATGAAGTACATCAGAACATGGGCTACTGCCCTCAGTTTGATGCCATCACAGAGCTG
TTGACTGGGAGAGAACACGTGGAGTTCTTTGCCCTTTTGAGAGGAGTCCCAGAGAAAGAA
GTTGGCAAGGTTGGTGAGTGGGCGATTCGGAAACTGGGCCTCGTGAAGTATGGAGAAAAA
TATGCTGGTAACTATAGTGGAGGCAACAAACGCAAGCTCTCTACAGCCATGGCTTTGATC
GGCGGGCCTCCTGTGGTGTTTCTGGATGAACCCACCACAGGCATGGATCCCAAAGCCCGG
CGGTTCTTGTGGAATTGTGCCCTAAGTGTTGTCAAGGAGGGGAGATCAGTAGTGCTTACA
TCTCATAGTATGGAAGAATGTGAAGCTCTTTGCACTAGGATGGCAATCATGGTCAATGGA
AGGTTCAGGTGCCTTGGCAGTGTCCAGCATCTAAAAAATAGGTTTGGAGATGGTTATACA
ATAGTTGTACGAATAGCAGGGTCCAACCCGGACCTGAAGCCTGTCCAGGATTTCTTTGGA
CTTGCATTTCCTGGAAGTGTTCYAAAAGAGAAACACCGGAACATGCTACAATACCAGCTT
CCATCTTCATTATCTTCTCTGGCCAGGATATTCAGCATCCTCTCCCAGAGCAAAAAGCGA
CTCCACATAGAAGACTACTCTGTTTCTCAGACAACACTTGACCAAGTATTTGTGAACTTT
GCCAAGGACCAAAGTGATGATGACCACTTAAAAGACCTCTCATTACACAAAAACCAGACA
GTAGTGGACGTTGCAGTTCTCACATCTTTTCTACAGGATGAGAAAGTGAAAGAAAGCTAT
GTATGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AF275948

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_1_Locus:
9q31.1

# Macromolecular_Interacting_Partner_1_SNPs:
rs2230808; rs2230806; rs4149313; rs2066718; rs33918808; rs9282541; rs35819696; rs2066715; rs9282543; rs35207495; rs7031748; rs2230805; rs35204915; rs2066716; rs34788556; rs9282546; rs34066619; rs35545593; rs9282539; rs13306077; rs2246841; rs9282538; rs13306075; rs9282537; rs41494750; rs2274873; rs2472455; rs9282547; rs34078184; rs363717; rs4149264; rs2575878; rs4149338; rs2791952; rs2487049; rs2472508; rs10512337; rs2515614; rs4149339; rs2472377; rs2740486; rs2516313; rs2487052; rs6479285; rs4149263; rs10512336; rs4149340; rs12003756; rs2437820; rs2437811; rs3905001; rs2515616; rs2777794; rs4149265; rs7872225; rs6479284; rs10991411; rs10991412; rs10820743; rs2515617; rs2575879; rs12347523; rs7035693; rs12335854; rs12347858; rs7861141; rs7049195; rs2254819; rs7857983; rs7861459; rs1800978; rs2515613; rs10820744; rs10991414; rs12344687; rs2437818; rs4742928; rs2472506; rs10991409; rs10991415; rs10991416; rs2243312; rs2437821; rs2472374; rs34165419; rs2515618; rs10991406; rs12237054; rs2487050; rs13291117; rs2437817; rs11792754; rs2777795; rs10521071; rs2575877; rs10991417; rs2575874; rs1799777; rs2515615; rs7035444; rs10512335; rs4149262; rs41474449; rs4100654; rs2515611; rs4149341; rs2472510; rs10991413; rs12343571; rs7849869; rs10512338; rs41432545; rs13284054; rs7030810; rs4742929; rs4149261; rs10991404; rs10991405; rs10820747; rs10991408; rs12350560; rs7872096; rs2472509; rs10991410; rs1175453; rs10820749; rs12336969; rs2472507; rs2254708; rs2740479; rs2740492; rs2740494; rs3858076; rs2482433; rs2740481; rs3818689; rs2472433; rs2487037; rs2472384; rs4149336; rs1883023; rs2740493; rs2575875; rs3904999; rs2777803; rs2777802; rs10115928; rs3858075; rs2791950; rs2020927; rs2740476; rs2254884; rs4149291; rs2297404; rs4149333; rs2487039; rs2777804; rs1331924; rs3904998; rs3847305; rs1999431; rs2066720; rs2472448; rs2297400; rs7024300; rs3847304; rs2297406; rs7047523; rs2777785; rs2243313; rs10121901; rs2777790; rs2482424; rs2777799; rs2777805; rs3780540; rs4149275; rs2275544; rs13292582; rs1999429; rs4149310; rs13306066; rs2020926; rs2297407; rs4149269; rs4743764; rs3029584; rs2253172; rs4742927; rs3847303; rs2482420; rs2777786; rs2472386; rs12001061; rs2472390; rs2274871; rs4149273; rs2065412; rs2249891; rs7043581; rs4149332; rs9282540; rs3758294; rs6479282; rs3831227; rs7859265; rs4149270; rs2472378; rs4743763; rs13290420; rs2740485; rs3847300; rs2275543; rs4149346; rs2740484; rs2417565; rs3780543; rs3824477; rs2297401; rs28652716; rs4149309; rs2253182; rs12003698; rs1929842; rs7025776; rs12002265; rs4149337; rs2777797; rs4149279; rs2575876; rs2472449; rs914546; rs2066717; rs2297409; rs3858074; rs2515629; rs4149281; rs2777787; rs2740499; rs2275542; rs2777784; rs914545; rs2253175; rs2482418; rs1929841; rs10820738; rs2472440; rs2000069; rs3847301; rs2253304; rs11790326; rs3904997; rs2740480; rs2777793; rs2777788; rs11789818; rs4149334; rs2297405; rs2275545; rs2777800; rs2515601; rs2487059; rs10820737; rs2066881; rs7341705; rs2515602; rs2297399; rs2740482; rs4149268; rs914544; rs2740491; rs1883025; rs2740487; rs12341993; rs3847302; rs12346461; rs4149327; rs12686004; rs11791258; rs4149331; rs2150867; rs4149267; rs4149272; rs2253174; rs4149335; rs10820736; rs2487058; rs7026408; rs2777801; rs4149302; rs1831553; rs9282545; rs2777789; rs2482421; rs2487055; rs2472381; rs3890182; rs13292026; rs7019569; rs10120087; rs2297398; rs13306069; rs2297402; rs4149290; rs2777798; rs2487065; rs41456650; rs3818688; rs7027801; rs2076731; rs10118061; rs3824478; rs12342847; rs10991389; rs4149274; rs4149323; rs2487062; rs4149326; rs9282544; rs13291863; rs2297408; rs2472437; rs4149294; rs2989944; rs4149320; rs2472438; rs12002435; rs11789603; rs2472441; rs2027403; rs7848844; rs4149301; rs7855185; rs41412244; rs1340354; rs2472434; rs2277181; rs9299383; rs7867698; rs2066882; rs4742926; rs2472383; rs4743762; rs4149329; rs1999430; rs10991390; rs4149284; rs2472436; rs2020928; rs2487057; rs4149296; rs4149271; rs2472439; rs6479283; rs2076730; rs4149299; rs12235875; rs13286991; rs10512334; rs10991386; rs4149319; rs7034361; rs12003906; rs4149324; rs1175293; rs4149321; rs4149311; rs7043081; rs9282549; rs12683676; rs1340353; rs4149297; rs2777791; rs2099544; rs7873387; rs13283515; rs2740488; rs11998937; rs4149308; rs2067484; rs12006437; rs10116972; rs10125482; rs10820732; rs3780546; rs2482434; rs4149316; rs4149303; rs12553591; rs4149289; rs3824479; rs2472435; rs13285112; rs2482422; rs3780542; rs4149295; rs3780541; rs41513444; rs9282542; rs41415046; rs4149328; rs4149283; rs4149325; rs10820733; rs41382749; rs12004453; rs12338782; rs2297403; rs4149282; rs2234885; rs4149307; rs2482419; rs2740478; rs9282548; rs3905000; rs9282550; rs2777792; rs2472450; rs3824481; rs7862756; rs7027196; rs1831554; rs2472385; rs1800977; rs2482432; rs10124728; rs2487048; rs10761085; rs2246293; rs2740483; rs12000659; rs2980083; rs2246298; rs2487046; rs2422493; rs10124755; rs2482437; rs34879708; rs13306072; rs4131108; rs28933692; rs1883024; rs2472458; rs13306068; rs28937313; rs2853578; rs13306073; rs2853574; rs2853577; rs1997618; rs41436749; rs28937314; rs34083760; rs35871586; rs34590907; rs41277767; rs41277763; rs35561837; rs34198118; rs2515609; rs11540326; rs11370908; rs12347784; rs12236519; rs11460644; rs10991377; rs12352393; rs12342233; rs10820748; rs35431611; rs34302197; rs34515440; rs12684473; rs5899625; rs11792330; rs2994375; rs1137170; rs34570900; rs12000590; rs34352903; rs35005766; rs33976424; rs2515612; rs10991402; rs2487051; rs11453300; rs10991407; rs35949087; rs13306079; rs7854775; rs4510920; rs13283308; rs36047954; rs28405388; rs34229509; rs10991418; rs11428977; rs11394015; rs12339957; rs2487053; rs13287957; rs35672247; rs36232543; rs10991403; rs11540325; rs3758297; rs35167860; rs41437944; rs28715489; rs34450679; rs35445387; rs3983640; rs35117818; rs35110205; rs2515610; rs35977928; rs34400919; rs33910960; rs12686280; rs28656304; rs2472373; rs12344527; rs13306080; rs1175456; rs2487060; rs35876406; rs35748412; rs35545100; rs3029650; rs974464; rs35267409; rs2118084; rs41422749; rs4149286; rs10991393; rs2515627; rs41277765; rs4149344; rs12341953; rs2472512; rs12351480; rs34813555; rs2472387; rs3029409; rs4742925; rs35093463; rs2472391; rs2740475; rs35139735; rs7041412; rs7020957; rs36053505; rs35204953; rs2437814; rs34538834; rs5899618; rs35185295; rs5899624; rs2020929; rs1340355; rs3215918; rs3842219; rs13306076; rs2740490; rs2791949; rs6151110; rs4149306; rs13291032; rs35792477; rs13306081; rs13286395; rs13299259; rs41419649; rs10991381; rs13285096; rs35124737; rs4149276; rs34153825; rs13296935; rs4149293; rs41335545; rs41504247; rs13285345; rs13297526; rs41426948; rs4742924; rs10991396; rs1175457; rs10661109; rs2515628; rs4149347; rs2482417; rs10991392; rs2472463; rs4149330; rs12341994; rs4149278; rs12350745; rs4149343; rs34544647; rs2487056; rs13292447; rs7027802; rs10991394; rs41513148; rs2274872; rs36122100; rs4149280; rs10583466; rs3780538; rs4149287; rs1175455; rs10991401; rs34564112; rs2777806; rs41456149; rs2515604; rs2482412; rs34004711; rs28599759; rs12348537; rs2472464; rs12340337; rs5899619; rs34171271; rs12351534; rs2482414; rs41537052; rs2791951; rs2740498; rs34203904; rs2472388; rs2472443; rs11404358; rs12335579; rs2740495; rs12004282; rs2245793; rs9409410; rs35474862; rs34239819; rs2472457; rs7040990; rs12344798; rs2472461; rs13285088; rs2482436; rs3215917; rs35028970; rs2980646; rs2282152; rs34484490; rs35840899; rs11788044; rs10114399; rs2066719; rs10583465; rs2472517; rs5007364; rs35543165; rs2515603; rs4149318; rs11433143; rs2472513; rs10991398; rs2472371; rs2777782; rs10690293; rs35016066; rs35366472; rs4149317; rs2472460; rs2472376; rs13301006; rs893058; rs7863889; rs2482435; rs4149298; rs34388261; rs7028667; rs28690796; rs34817114; rs34831628; rs11304201; rs2472470; rs3887301; rs7046079; rs13306082; rs35543524; rs34364224; rs2516322; rs1175454; rs13297344; rs11392079; rs4149304; rs2740477; rs35683917; rs3780539; rs2472389; rs10991387; rs34561897; rs13285117; rs34153967; rs3900832; rs2482413; rs13301802; rs34144130; rs7032574; rs4454344; rs35010837; rs2282153; rs13289355; rs5007365; rs4149300; rs34713310; rs13285437; rs2482415; rs4149349; rs28633842; rs35594183; rs41410048; rs41372647; rs41483745; rs2244278; rs36098089; rs34174449; rs4149315; rs4149288; rs11443334; rs34268559; rs10593949; rs13306078; rs10991383; rs36050540; rs5899622; rs2472372; rs2487063; rs10697892; rs2472445; rs12347789; rs2472514; rs2740496; rs1953011; rs10115901; rs13288250; rs7042310; rs5899621; rs13295806; rs10820735; rs36015529; rs10124686; rs10991397; rs2777783; rs34567819; rs7034035; rs34542857; rs34624257; rs35053902; rs4506285; rs41445345; rs2487061; rs2472375; rs36028500; rs4149266; rs7857007; rs4149285; rs11443333; rs2980645; rs13306067; rs10614372; rs13295662; rs2515626; rs4149314; rs2472370; rs4149345; rs12341868; rs10693809; rs35699471; rs10695751; rs41391445; rs11788803; rs34650643; rs2472442; rs10991395; rs13301674; rs4149292; rs5007363; rs13306070; rs2472454; rs10697891; rs5899617; rs34806386; rs35914252; rs11791454; rs41371845; rs2472444; rs13298930; rs35796082; rs34121951; rs28523599; rs2791948; rs35676433; rs2515625; rs11433144; rs2472382; rs2740497; rs4743761; rs1340352; rs7033623; rs2472462; rs34390877; rs13284961; rs7860348; rs3983644; rs35789429; rs10820740; rs35990533; rs10991385; rs4149348; rs12551384; rs10991391; rs4149277; rs35118541; rs34311859; rs28558214; rs28453232; rs41297205; rs34206414; rs13306074; rs35660402; rs5899623; rs2482416; rs10991388; rs3837273; rs13286494; rs2482423; rs3983647; rs33980331; rs28714441; rs2515600; rs41354653; rs35497119; rs2487064; rs12344156; rs34642413; rs41403644; rs2487047; rs1800976; rs2472380; rs16936183; rs34385550; rs3021455; rs16926146; rs34258946; rs28408753; rs16905745; rs2422492; rs34669957; rs2980082; rs33971077; rs2472379; rs4149342; rs11432680; rs7035955; rs10991420; rs13306071; rs2437815; rs10991419; rs34250431; rs10117535; rs10820730; rs12553329; rs2043664; rs2437819; rs2472474; rs2472482; rs2472483; rs2472485; rs2472486; rs2472487; rs2472488; rs2472489; rs2472490; rs2472495; rs2472496; rs2482429; rs2482430; rs2487038; rs2487042; rs2487054; rs2487718; rs2515606; rs2515608; rs28587567; rs2994376; rs3887137; rs4742923; rs4743765; rs7866586

# Macromolecular_Interacting_Partner_1_General_References:
10884428; 11352567; 10092505; 10431238; 12196520; 11279031; 12032171; 12763760; 10533863; 10431236; 10431237; 11086027; 10706591; 10938021; 11257260; 11257261; 11476961; 11476965; 11238261; 12204794; 12009425; 11785958; 12966036

# Macromolecular_Interacting_Partner_1_References:
16936198; 16938301; 16940190; 16946132

# Macromolecular_Interacting_Partner_2_ID:
7544

# Macromolecular_Interacting_Partner_2_Name:
Low-density lipoprotein receptor precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
LDL receptor

# Macromolecular_Interacting_Partner_2_Gene_Name:
LDLR

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Lowdensity lipoprotein receptor precursor
MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK
CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW
PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE
FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR
DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD
PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT
SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA
VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA
KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE
DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ
PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA
TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN
EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH
NQDGYSYPSRQMVSLEDDVA

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
860

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
95376

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
4.64

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00008:EGF;
PF07645:EGF_CA;
PF00057:Ldl_recept_a;
PF00058:Ldl_recept_b

# Macromolecular_Interacting_Partner_2_Signals:
1-21

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
789-810

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
307121

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
LDLR_HUMAN (P01130)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
LDLR

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
LDLR

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:6547

# Macromolecular_Interacting_Partner_2_PDB_ID:
1N7D

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>2583 bp
ATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGG
ACTGCAGTGGGCGACAGATGTGAAAGAAACGAGTTCCAGTGCCAAGACGGGAAATGCATC
TCCTACAAGTGGGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAG
GAGACGTGCTTGTCTGTCACCTGCAAATCCGGGGACTTCAGCTGTGGGGGCCGTGTCAAC
CGCTGCATTCCTCAGTTCTGGAGGTGCGATGGCCAAGTGGACTGCGACAACGGCTCAGAC
GAGCAAGGCTGTCCCCCCAAGACGTGCTCCCAGGACGAGTTTCGCTGCCACGATGGGAAG
TGCATCTCTCGGCAGTTCGTCTGTGACTCAGACCGGGACTGCTTGGACGGCTCAGACGAG
GCCTCCTGCCCGGTGCTCACCTGTGGTCCCGCCAGCTTCCAGTGCAACAGCTCCACCTGC
ATCCCCCAGCTGTGGGCCTGCGACAACGACCCCGACTGCGAAGATGGCTCGGATGAGTGG
CCGCAGCGCTGTAGGGGTCTTTACGTGTTCCAAGGGGACAGTAGCCCCTGCTCGGCCTTC
GAGTTCCACTGCCTAAGTGGCGAGTGCATCCACTCCAGCTGGCGCTGTGATGGTGGCCCC
GACTGCAAGGACAAATCTGACGAGGAAAACTGCGCTGTGGCCACCTGTCGCCCTGACGAA
TTCCAGTGCTCTGATGGAAACTGCATCCATGGCAGCCGGCAGTGTGACCGGGAATATGAC
TGCAAGGACATGAGCGATGAAGTTGGCTGCGTTAATGTGACACTCTGCGAGGGACCCAAC
AAGTTCAAGTGTCACAGCGGCGAATGCATCACCCTGGACAAAGTCTGCAACATGGCTAGA
GACTGCCGGGACTGGTCAGATGAACCCATCAAAGAGTGCGGGACCAACGAATGCTTGGAC
AACAACGGCGGCTGTTCCCACGTCTGCAATGACCTTAAGATCGGCTACGAGTGCCTGTGC
CCCGACGGCTTCCAGCTGGTGGCCCAGCGAAGATGCGAAGATATCGATGAGTGTCAGGAT
CCCGACACCTGCAGCCAGCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAG
GAAGGCTTCCAGCTGGACCCCCACACGAAGGCCTGCAAGGCTGTGGGCTCCATCGCCTAC
CTCTTCTTCACCAACCGGCACGAGGTCAGGAAGATGACGCTGGACCGGAGCGAGTACACC
AGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGAGGTGGCCAGCAATAGA
ATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGCACCCAGCTTGACAGAGCCCAC
GGCGTCTCTTCCTATGACACCGTCATCAGCAGGGACATCCAGGCCCCCGACGGGCTGGCT
GTGGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTT
GCGGATACCAAGGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGG
GCCATCGTGGTGGATCCTGTTCATGGCTTCATGTACTGGACTGACTGGGGAACTCCCGCC
AAGATCAAGAAAGGGGGCCTGAATGGTGTGGACATCTACTCGCTGGTGACTGAAAACATT
CAGTGGCCCAATGGCATCACCCTAGATCTCCTCAGTGGCCGCCTCTACTGGGTTGACTCC
AAACTTCACTCCATCTCAAGCATCGATGTCAATGGGGGCAACCGGAAGACCATCTTGGAG
GATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGACAAAGTATTTTGG
ACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAAC
TTGTTGGCTGAAAACCTACTGTCCCCAGAGGATATGGTCCTCTTCCACAACCTCACCCAG
CCAAGAGGAGTGAACTGGTGTGAGAGGACCACCCTGAGCAATGGCGGCTGCCAGTATCTG
TGCCTCCCTGCCCCGCAGATCAACCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGAC
GGCATGCTGCTGGCCAGGGACATGAGGAGCTGCCTCACAGAGGCTGAGGCTGCAGTGGCC
ACCCAGGAGACATCCACCGTCAGGCTAAAGGTCAGCTCCACAGCCGTAAGGACACAGCAC
ACAACCACCCGGCCTGTTCCCGACACCTCCCGGCTGCCTGGGGCCACCCCTGGGCTCACC
ACGGTGGAGATAGTGACAATGTCTCACCAAGCTCTGGGCGACGTTGCTGGCAGAGGAAAT
GAGAAGAAGCCCAGTAGCGTGAGGGCTCTGTCCATTGTCCTCCCCATCGTGCTCCTCGTC
TTCCTTTGCCTGGGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGC
ATCAACTTTGACAACCCCGTCTATCAGAAGACCACAGAGGATGAGGTCCACATTTGCCAC
AACCAGGACGGCTACAGCTACCCCTCGAGACAGATGGTCAGTCTGGAGGATGACGTGGCG
TGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
L00352

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_2_Locus:
19p13.3

# Macromolecular_Interacting_Partner_2_SNPs:
rs11669576; rs5932; rs7508676; rs5927; rs1799898; rs688; rs5930; rs5929; rs5933; rs5925; rs1799948; rs5926; rs2228671; rs1433099; rs14158; rs2738465; rs2738464; rs2738466; rs13344419; rs7254521; rs7258146; rs5742911; rs2738467; rs3826810; rs10409044; rs17243018; rs17249064; rs17242683; rs17249057; rs17249029; rs17242677; rs17243025; rs10415069; rs2978615; rs2915966; rs17249078; rs17243011; rs17243004; rs2116898; rs1010679; rs7259278; rs1003723; rs6511720; rs8102912; rs3745677; rs12459476; rs8110695; rs2738459; rs2738460; rs4804145; rs2116897; rs2738445; rs2304181; rs4804144; rs7248981; rs6511721; rs9789328; rs4508523; rs2738456; rs1569372; rs6413504; rs2569540; rs885765; rs2738446; rs8106324; rs17248931; rs3786730; rs2569538; rs2738455; rs2116899; rs2738444; rs4804143; rs7247905; rs2738457; rs2304182; rs2569543; rs12983082; rs10422256; rs2569559; rs6413503; rs2915967; rs6413505; rs17248840; rs2569555; rs8104549; rs2738454; rs10417295; rs2569542; rs7256073; rs2569537; rs8101764; rs8104576; rs17249218; rs6511724; rs2569539; rs10423288; rs1962352; rs2738449; rs2738452; rs10401667; rs10422244; rs13345161; rs2738458; rs10425654; rs3826807; rs17242499; rs2738447; rs2738450; rs17242395; rs17248973; rs17242857; rs17248833; rs17248889; rs17242353; rs17249316; rs9789303; rs3826808; rs12611153; rs17248952; rs17249330; rs17242381; rs17249169; rs17248776; rs17242635; rs17242437; rs17248769; rs17242920; rs17249351; rs12611067; rs9789302; rs10402435; rs17242367; rs17248903; rs17249309; rs11667264; rs17248812; rs8106826; rs17249323; rs17248854; rs17242402; rs17249358; rs892116; rs12610872; rs8107680; rs13306501; rs12610626; rs17242472; rs12710260; rs17249281; rs17242479; rs17242962; rs17242444; rs2304183; rs13346401; rs17242451; rs11880993; rs17249302; rs17249001; rs2569556; rs12981050; rs13306513; rs17242586; rs17249288; rs8111982; rs17248783; rs11671392; rs17242541; rs7247118; rs17248819; rs12609673; rs17249365; rs17248748; rs17242739; rs17248720; rs17248727; rs17242346; rs8112638; rs17242746; rs17249400; rs17248734; rs17249127; rs12611315; rs28942079; rs13306505; rs13306510; rs2569548; rs11547917; rs28942078; rs5931; rs5928; rs13306515; rs13306512; rs10417394; rs13306498; rs13306508; rs28398082; rs13306509; rs8108932; rs35740761; rs35874897; rs3980933; rs17249393; rs17249379; rs5827117; rs34113544; rs1061878; rs34890611; rs35921663; rs11668032; rs35653724; rs34349603; rs17242976; rs17249246; rs2738461; rs41301949; rs17248882; rs17249295; rs34847973; rs34399363; rs35753783; rs17242808; rs3745678; rs35292163; rs28493980; rs34008246; rs35246543; rs2738463; rs17249225; rs17249232; rs35878749; rs12974008; rs17242374; rs13306497; rs35069757; rs17242941; rs4507018; rs34869154; rs4464197; rs17242878; rs13306499; rs13306504; rs2569545; rs17242780; rs28786710; rs2738442; rs17242836; rs17242801; rs3837951; rs2738448; rs34505568; rs2569557; rs2569550; rs4143061; rs2738451; rs10404864; rs17242829; rs2738462; rs17249267; rs17248805; rs17249344; rs2569546; rs17249197; rs17242850; rs17242388; rs17242822; rs17249176; rs7255762; rs17242787; rs33934122; rs41306974; rs17242766; rs12981100; rs2569541; rs17242492; rs12609933; rs2738443; rs13306511; rs36096887; rs2569553; rs28707744; rs34982945; rs34554139; rs17242885; rs28430933; rs17242773; rs34444274; rs17242983; rs17242843; rs17249162; rs2569558; rs17242759; rs17248959; rs34695199; rs17249211; rs35684019; rs3980931; rs17242423; rs11085760; rs17242416; rs28410440; rs2569544; rs17249190; rs12983860; rs34770550; rs3980930; rs17242871; rs2978614; rs17242997; rs34093283; rs41301947; rs34510804; rs17242899; rs17249204; rs35951147; rs2569547; rs2569554; rs2569551; rs36018670; rs17242969; rs17242906; rs12985460; rs35346913; rs17248924; rs2738453; rs17242864; rs41307025; rs2569549; rs34547422; rs3041965; rs36218923; rs17242752; rs17249141; rs17249085; rs36219255; rs17242732; rs35235639; rs17249120; rs28457782; rs7507927; rs17249134; rs35293613; rs11668477; rs11672123; rs12608650; rs12611383; rs35453549; rs35969362; rs36005514; rs4804568; rs7249753

# Macromolecular_Interacting_Partner_2_General_References:
6091915; 2988123; 3005267; 3104336; 12754519; 12615904; 7603991; 7578052; 9262405; 1301956; 9016531; 3263645; 2569482; 3955657; 8347689; 2318961; 1446662; 1867200; 8462973; 8168830; 2726768; 1464748; 7573037; 7583548; 7550239; 7635461; 7635482; 7649546; 7649549; 8740918; 8664907; 9026534; 9254862; 9143924; 9259195; 9104431; 9654205; 9452094; 9452095; 9452118; 9852677; 9678702; 10422803; 10090484; 10447263; 10391209; 10882754; 11298688

# Macromolecular_Interacting_Partner_2_References:
16970948; 16987874; 17003234; 17043631

# Macromolecular_Interacting_Partner_3_ID:
7549

# Macromolecular_Interacting_Partner_3_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
INS

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_3_Signals:
1-24

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
INS

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11p15.5

# Macromolecular_Interacting_Partner_3_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_3_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_3_References:
16968812; 17024038; 17072583; 17087600

# Macromolecular_Interacting_Partner_4_ID:
7551

# Macromolecular_Interacting_Partner_4_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_4_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_4_Locus:
6p21.3

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_4_References:
16984105; 17028163; 17062603; 17148666

# Macromolecular_Interacting_Partner_5_ID:
6943

# Macromolecular_Interacting_Partner_5_Name:
Apolipoprotein A-I precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
Apo-AI; ApoA-I[Contains: Apolipoprotein A-I(1-242]

# Macromolecular_Interacting_Partner_5_Gene_Name:
APOA1

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Apolipoprotein AI precursor
MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS
ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK
VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV
DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ
GLLPVLESFKVSFLSALEEYTKKLNTQ

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
267

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
30778

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
5.50

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  binding
Function:  lipid binding
 ||
>>>
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  lipoprotein metabolism
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  lipid transport
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT)

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF01442:Apolipoprotein

# Macromolecular_Interacting_Partner_5_Signals:
1-18

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
178768

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
APOA1_HUMAN (P02647)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
APOA1

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
APOA1

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:600

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>804 bp
ATGAAAGCTGCGGTGCTGACCTTGGCCGTGCTCTTCCTGACGGGGAGCCAGGCTCGGCAT
TTCTGGCAGCAAGATGAACCCCCCCAGAGCCCCTGGGATCGAGTGAAGGACCTGGCCACT
GTGTACGTGGATGTGCTCAAAGACAGCGGCAGAGACTATGTGTCCCAGTTTGAAGGCTCC
GCCTTGGGAAAACAGCTAAACCTAAAGCTCCTTGACAACTGGGACAGCGTGACCTCCACC
TTCAGCAAGCTGCGCGAACAGCTCGGCCCTGTGACCCAGGAGTTCTGGGATAACCTGGAA
AAGGAGACAGAGGGCCTGAGGCAAGAGATGAGCAAGGATCTGGAGGAGGTGAAGGCCAAG
GTGCAGCCCTACCTGGACGACTTCCAGAAGAAGTGGCAGGAGGAGATGGAGCTCTACCGC
CAGAAGGTGGAGCCGCTGCGCGCAGAGCTCCAAGAGGGCGCGCGCCAGAAGCTGCACGAG
CTGCAAGAGAAGCTGAGCCCACTGGGCGAGGAGATGCGCGACCGCGCGCGCGCCCATGTG
GACGCGCTGCGCACGCATCTGGCCCCCTACAGCGACGAGCTGCGCCAGCGCTTGGCCGCG
CGCCTTGAGGCTCTCAAGGAGAACGGCGGCGCCAGACTGGCCGAGTACCACGCCAAGGCC
ACCGAGCATCTGAGCACGCTCAGCGAGAAGGCCAAGCCCGCGCTCGAGGACCTCCGCCAA
GGCCTGCTGCCCGTGCTGGAGAGCTTCAAGGTCAGCTTCCTGAGCGCTCTCGAGGAGTAC
ACTAAGAAGCTCAACACCCAGTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
J00098

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_5_Locus:
11q23-q24

# Macromolecular_Interacting_Partner_5_SNPs:
rs5077; rs5078; rs5080; rs5079; rs5071; rs5069; rs5070; rs7116797; rs2070665; rs12718464; rs5076; rs5075; rs5072; rs12718462; rs11216153; rs5081; rs670; rs12721026; rs12718466; rs1374117; rs12691374; rs12721025; rs12721031; rs632153; rs12718463; rs12721030; rs7948159; rs525028; rs17249407; rs10750098; rs28931573; rs1053223; rs17145083; rs28931575; rs4882; rs28931574; rs28929476; rs2727787; rs14081; rs1052925; rs3178226; rs1799837; rs13306170; rs4018880; rs2727786; rs34709608; rs35501318; rs2727785; rs2542053; rs2542054; rs2849171; rs34488176; rs1145207; rs2070669; rs2071522; rs35625356; rs4520; rs5128

# Macromolecular_Interacting_Partner_5_General_References:
6406984; 6304641; 6413973; 6207999; 6328445; 6198645; 2995392; 3129297; 2673706; 6409108; 164450; 204308; 3047170; 2506184; 3120314; 7895732; 12665801; 6294659; 3005308; 6405383; 12562854; 8664326; 9356442; 8240372; 8282791; 6401735; 6412234; 6489332; 6432779; 3142462; 2123470; 2107878; 1502149; 2108924; 2512329; 2111322; 7918609; 9514407; 12966036

# Macromolecular_Interacting_Partner_5_References:
16973241; 16984907; 16990644; 17012138

# Macromolecular_Interacting_Partner_6_ID:
7424

# Macromolecular_Interacting_Partner_6_Name:
Apolipoprotein E precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
Apo-E

# Macromolecular_Interacting_Partner_6_Gene_Name:
APOE

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Apolipoprotein E precursor
MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQT
LSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQA
RLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVY
QAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMG
SRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEK
VQAAVGTSAAPVPSDNH

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
317

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
36155

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
5.42

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  binding
Function:  lipid binding
 ||
>>>
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  lipoprotein metabolism
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  lipid transport
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_6_General_Function:
Replication, recombination and repair 

# Macromolecular_Interacting_Partner_6_Specific_Function:
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF01442:Apolipoprotein

# Macromolecular_Interacting_Partner_6_Signals:
1-18

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
178849

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
APOE_HUMAN (P02649)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
APOE

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
APOE

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:613

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>954 bp
ATGAAGGTTCTGTGGGCTGCGTTGCTGGTCACATTCCTGGCAGGATGCCAGGCCAAGGTG
GAGCAAGCGGTGGAGACAGAGCCGGAGCCCGAGCTGCGCCAGCAGACCGAGTGGCAGAGC
GGCCAGCGCTGGGAACTGGCACTGGGTCGCTTTTGGGATTACCTGCGCTGGGTGCAGACA
CTGTCTGAGCAGGTGCAGGAGGAGCTGCTCAGCTCCCAAGTCACCCAAGAACTGAGGGCG
CTGATGGACGAGACCATGAAGGAGTTGAAGGCCTACAAATCGGAACTGGAGGAACAACTG
ACCCCGGTAGCGGAGGAGACGCGGGCACGGCTGTCCAAGGAGCTGCAGACGGCGCAGGCC
CGGCTGGGCGCGGACATGGAGGACGTGTGCGGCCGCCTGGTGCAGTACCGCGGCGAGGTG
CAGGCCATGCTCGGCCAGAGCACCGAGGAGCTGCGGGTGCGCCTCGCCTCCCACCTGCGC
AAGCTGCGTAAGCGGCTCCTCCGCGATCCCGATGACCTGCAGAAGCGCCTGGCAGTGTAC
CAGGCCGGGGCCCGCGAGGGCGCCGAGCGCGGCCTCAGCGCCATCCGCGAGCGCCTGGGG
CCCCTGGTGGAACAGGGCCGCGTGCGGGCCGCCACTGTGGGCTCCCTGGCCGGCCAGCCG
CTACAGGAGCGGGCCCAGGCCTGGGGCGAGCGGCTGCGCGCGCGGATGGAGGAGATGGGC
AGTCGGACCCGCGACCGCCTGGACGAGGTGAAGGAGCAGGTGGCGGAGGTGCGCGCCAAG
CTGGAGGAGCAGGCCCAGCAGATACGCCTGCAGGCCGAGGCCTTCCAGGCCCGCCTCAAG
AGCTGGTTCGAGCCCCTGGTGGAAGACATGCAGCGCCAGTGGGCCGGGCTGGTGGAGAAG
GTGCAGGCTGCCGTGGGCACCAGCGCCGCCCCTGTGCCCAGCGACAATCACTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
M12529

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_6_Locus:
19q13.2

# Macromolecular_Interacting_Partner_6_SNPs:
rs769452; rs429358; rs7412; rs769455; rs877973; rs440446; rs9282609; rs769449; rs769450; rs405509; rs449647; rs7259620; rs439382; rs1081105; rs434132; rs769446; rs11542041; rs28931579; rs11542035; rs41382345; rs28931578; rs11542029; rs11542034; rs28931577; rs11083750; rs11542032; rs11542027; rs28931576; rs11542030; rs11542040; rs11542037; rs11542033; rs11542038; rs11542031; rs11542039; rs13306211; rs769448; rs769447; rs1809337; rs1809338; rs12982192; rs1809339; rs2007708; rs769454; rs769451; rs1799982; rs1799981; rs769445; rs1081101; rs1081103; rs7256173; rs10119; rs1064725; rs1160984; rs1160985; rs11881832; rs12691088; rs12721054; rs34459630; rs382614; rs389261; rs394819; rs417357; rs435380; rs439401; rs446037; rs5114; rs741780; rs760136; rs8106922

# Macromolecular_Interacting_Partner_6_General_References:
6325438; 6327682; 2987927; 3243553; 10520737; 7068630; 6897404; 8346443; 2556398; 2760009; 1674745; 8287539; 8488843; 9360638; 12864777; 12966036; 3947350; 3283935; 7833947; 2063194; 8756331; 10850798

# Macromolecular_Interacting_Partner_6_References:
16956959; 16973241; 17000013; 17121837

# Macromolecular_Interacting_Partner_7_ID:
7554

# Macromolecular_Interacting_Partner_7_Name:
C-reactive protein precursor [Contains: C-reactive protein(1-205)]

# Macromolecular_Interacting_Partner_7_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Name:
CRP

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Creactive protein precursor Contains: Creactive protein1205
MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTE
LSSTRGYSIF
SYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWE
SASGIVEFWVDGKPRVRKSLK
KGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVN
MWDFVLSPDEINTIYLGGPFSPNVLNWRALKY
EVQGEVFTKPQLWP

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
224

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
25039

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
5.32

# Macromolecular_Interacting_Partner_7_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Displays several functions associated with host defense:it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00354:Pentaxin

# Macromolecular_Interacting_Partner_7_Signals:
1-18

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
181066

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
CRP_HUMAN (P02741)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
CRP

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
CRP

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:2367

# Macromolecular_Interacting_Partner_7_PDB_ID:
1LJ7

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>675 bp

ATGGAGAAGCTGTTGTGTTTCTTGGTCTTGACCAGCCTCTCTCATGCTTTTGGCCAGAC
AGACATGTCGA
GGAAGGCTTTTGTGTTTCCCAAAGAGTCGGATACTTCCTATGTATCCC
TCAAAGCACCGTTAACGAAGCC
TCTCAAAGCCTTCACTGTGTGCCTCCACTTCTACACG
GAACTGTCCTCGACCCGTGGGTACAGTATTTTC
TCGTATGCCACCAAGAGACAAGACAA
TGAGATTCTCATATTTTGGTCTAAGGATATAGGATACAGTTTTA
CAGTGGGTGGGTCTG
AAATATTATTCGAGGTTCCTGAAGTCACAGTAGCTCCAGTACACATTTGTACAAG
CTGG
GAGTCCGCCTCAGGGATCGTGGAGTTCTGGGTAGATGGGAAGCCCAGGGTGAGGAAGAGT
CTGAAG
AAGGGATACACTGTGGGGGCAGAAGCAAGCATCATCTTGGGGCAGGAGCAGGA
TTCCTTCGGTGGGAACT
TTGAAGGAAGCCAGTCCCTAGTGGGAGACATTGGAAATGTGA
ACATGTGGGACTTTGTGCTGTCACCAGA
TGAGATTAACACCATCTATCTTGGCGGGCCC
TTCAGTCCTAATGTCCTGAACTGGCGGGCACTGAAGTAT
GAAGTGCAAGGCGAAGTGTT
CACCAAACCCCAGCTGTGGCCCTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
M11880

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_7_Locus:
1q21-q23

# Macromolecular_Interacting_Partner_7_SNPs:
rs35500644; rs1800947; rs35661750; rs36061058; rs1205; rs1130864; rs3093066; rs6413467; rs3093067; rs6413466; rs6413465; rs35111807; rs3116639; rs35031149; rs35475549; rs3116640; rs35664422; rs3093065; rs3116638; rs34034945; rs1417938; rs2808630; rs3093069; rs3093059; rs3093058; rs3093063; rs2808631; rs2794521; rs3093062; rs34777394; rs3093064; rs3093070; rs34140318; rs34237801; rs34188124; rs34684835; rs3093061; rs35716711; rs9282659; rs3091244; rs3122011; rs34527024; rs34260214; rs3093071; rs3093068; rs3093080; rs34340208; rs34672691; rs34200896; rs3116637; rs17860478; rs35972670; rs17860479; rs35086834; rs34457301; rs34385396; rs1050031; rs17860477; rs34640800; rs17860482; rs5778130; rs5778129; rs34138282; rs34259602; rs35935050; rs3122010; rs3116642; rs3093072; rs3116644; rs17860485; rs36033188; rs36079446; rs34035412; rs3116641; rs34226713; rs34379069; rs3116643; rs35668639; rs35114580; rs34408893; rs3093073; rs3093060; rs11265258; rs11265259; rs12068753; rs12069519; rs12079772; rs12084589; rs12742963; rs1341665; rs1572970; rs16842559; rs16842568; rs2027471; rs2211321; rs2211322; rs2246469; rs2794520; rs2808628; rs2808629; rs2808634; rs2808635; rs3093075; rs3093077; rs3093079; rs3116635; rs3116636; rs3116649; rs3116656; rs3122008; rs3122012; rs6667499; rs7411419; rs876537; rs876538

# Macromolecular_Interacting_Partner_7_General_References:
2997165; 3840479; 6685157; 6857266; 762075; 403526; 7881902; 8599761; 10368284

# Macromolecular_Interacting_Partner_7_References:
16990410; 17143126

# Macromolecular_Interacting_Partner_8_ID:
7556

# Macromolecular_Interacting_Partner_8_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_8_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_8_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_8_Signals:
1-18

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_8_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_8_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_8_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_8_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_8_References:
16952410; 17050774

# Macromolecular_Interacting_Partner_9_ID:
6198

# Macromolecular_Interacting_Partner_9_Name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase

# Macromolecular_Interacting_Partner_9_Synonyms:
HMG-CoA reductase

# Macromolecular_Interacting_Partner_9_Gene_Name:
HMGCR

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>3hydroxy3methylglutarylcoenzyme A reductase
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT
QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS
SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV
AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRAC
DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI
SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV
LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR
IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
888

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
97477

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
6.72

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  hydroxymethylglutaryl-CoA reductase (NADPH) activity
Function:  hydroxymethylglutaryl-CoA reductase (NADPH) activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  hydroxymethylglutaryl-CoA reductase (NADPH) activity
 ||
>>>
Process:  primary metabolism
Process:  lipid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  organelle membrane
Component:  endoplasmic reticulum membrane
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_9_General_Function:
Lipid transport and metabolism 

# Macromolecular_Interacting_Partner_9_Specific_Function:
This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis

# Macromolecular_Interacting_Partner_9_Pathway:
map00100  Biosynthesis of steroids

# Macromolecular_Interacting_Partner_9_Reaction:
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00368:HMG-CoA_red

# Macromolecular_Interacting_Partner_9_Signals:
1-23

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
EC 1.1.1.34

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
306865

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
HMDH_HUMAN (P04035)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
HMGCR

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
HMGCR

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:5006

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein. Peroxisome; peroxisomal membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>2667 bp
ATGTTGTCAAGACTTTTTCGAATGCATGGCCTCTTTGTGGCCTCCCATCCCTGGGAAGTC
ATAGTGGGGACAGTGACACTGACCATCTGCATGATGTCCATGAACATGTTTACTGGTAAC
AATAAGATCTGTGGTTGGAATTATGAATGTCCAAAGTTTGAAGAGGATGTTTTGAGCAGT
GACATTATAATTCTGACAATAACACGATGCATAGCCATCCTGTATATTTACTTCCAGTTC
CAGAATTTACGTCAACTTGGATCAAAATATATTTTGGGTATTGCTGGCCTTTTCACAATT
TTCTCAAGTTTTGTATTCAGTACAGTTGTCATTCACTTCTTAGACAAAGAATTGACAGGC
TTGAATGAAGCTTTGCCCTTTTTCCTACTTTTGATTGACCTTTCCAGAGCAAGCACATTA
GCAAAGTTTGCCCTCAGTTCCAACTCACAGGATGAAGTAAGGGAAAATATTGCTCGTGGA
ATGGCAATTTTAGGTCCTACGTTTACCCTCGATGCTCTTGTTGAATGTCTTGTGATTGGA
GTTGGTACCATGTCAGGGGTACGTCAGCTTGAAATTATGTGCTGCTTTGGCTGCATGTCA
GTTCTTGCCAACTACTTCGTGTTCATGACTTTCTTCCCAGCTTGTGTGTCCTTGGTATTA
GAGCTTTCTCGGGAAAGCCGCGAGGGTCGTCCAATTTGGCAGCTCAGCCATTTTGCCCGA
GTTTTAGAAGAAGAAGAAAATAAGCCGAATCCTGTAACTCAGAGGGTCAAGATGATTATG
TCTCTAGGCTTGGTTCTTGTTCATGCTCACAGTCGCTGGATAGCTGATCCTTCTCCTCAA
AACAGTACAGCAGATACTTCTAAGGTTTCATTAGGACTGGATGAAAATGTGTCCAAGAGA
ATTGAACCAAGTGTTTCCCTCTGGCAGTTTTATCTCTCTAAAATGATCAGCATGGATATT
GAACAAGTTATTACCCTAAGTTTAGCTCTCCTTCTGGCTGTCAAGTACATCTTCTTTGAA
CAAACAGAGACAGAATCTACACTCTCATTAAAAAACCCTATCACATCTCCTGTAGTGACA
CAAAAGAAAGTCCCAGACAATTGTTGTAGACGTGAACCTATGCTGGTCAGAAATAACCAG
AAATGTGATTCAGTAGAGGAAGAGACAGGGATAAACCGAGAAAGAAAAGTTGAGGTTATA
AAACCCTTAGTGGCTGAAACAGATACCCCAAACAGAGCTACATTTGTGGTTGGTAACTCC
TCCTTACTCGATACTTCATCAGTACTGGTGACACAGGAACCTGAAATTGAACTTCCCAGG
GAACCTCGGCCTAATGAAGAATGTCTACAGATACTTGGGAATGCAGAGAAAGGTGCAAAA
TTCCTTAGTGATGCTGAGATCATCCAGTTAGTCAATGCTAAGCATATCCCAGCCTACAAG
TTGGAAACTCTGATGGAAACTCATGAGCGTGGTGTATCTATTCGCCGACAGTTACTTTCC
AAGAAGCTTTCAGAACCTTCTTCTCTCCAGTACCTACCTTACAGGGATTATAATTACTCC
TTGGTGATGGGAGCTTGTTGTGAGAATGTTATTGGATATATGCCCATCCCTGTTGGAGTG
GCAGGACCCCTTTGCTTAGATGAAAAAGAATTTCAGGTTCCAATGGCAACAACAGAAGGT
TGTCTTGTGGCCAGCACCAATAGAGGCTGCAGAGCAATAGGTCTTGGTGGAGGTGCCAGC
AGCCGAGTCCTTGCAGATGGGATGACTCGTGGCCCAGTTGTGCGTCTTCCACGTGCTTGT
GACTCTGCAGAAGTGAAAGCCTGGCTCGAAACATCTGAAGGGTTCGCAGTGATAAAGGAG
GCATTTGACAGCACTAGCAGATTTGCACGTCTACAGAAACTTCATACAAGTATAGCTGGA
CGCAACCTTTATATCCGTTTCCAGTCCAGGTCAGGGGATGCCATGGGGATGAACATGATT
TCAAAGGGTACAGAGAAAGCACTTTCAAAACTTCACGAGTATTTCCCTGAAATGCAGATT
CTAGCCGTTAGTGGTAACTATTGTACTGACAAGAAACCTGCTGCTATAAATTGGATAGAG
GGAAGAGGAAAATCTGTTGTTTGTGAAGCTGTCATTCCAGCCAAGGTTGTCAGAGAAGTA
TTAAAGACTACCACAGAGGCTATGATTGAGGTCAACATTAACAAGAATTTAGTGGGCTCT
GCCATGGCTGGGAGCATAGGAGGCTACAACGCCCATGCAGCAAACATTGTCACCGCCATC
TACATTGCCTGTGGACAGGATGCAGCACAGAATGTTGGTAGTTCAAACTGTATTACTTTA
ATGGAAGCAAGTGGTCCCACAAATGAAGATTTATATATCAGCTGCACCATGCCATCTATA
GAGATAGGAACGGTGGGTGGTGGGACCAACCTACTACCTCAGCAAGCCTGTTTGCAGATG
CTAGGTGTTCAAGGAGCATGCAAAGATAATCCTGGGGAAAATGCCCGGCAGCTTGCCCGA
ATTGTGTGTGGGACCGTAATGGCTGGGGAATTGTCACTTATGGCAGCATTGGCAGCAGGA
CATCTTGTCAAAAGTCACATGATTCACAACAGGTCGAAGATCAATTTACAAGACCTCCAA
GGAGCTTGCACCAAGAAGACAGCCTGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
M11058

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_9_Locus:
5q13.3-q14

# Macromolecular_Interacting_Partner_9_SNPs:
rs5908; rs10038095; rs12916; rs10045497; rs5909; rs17883498; rs17244932; rs17238554; rs17238379; rs17244771; rs17238372; rs17244764; rs17238393; rs17244757; rs17244743; rs17244778; rs6805; rs10474435; rs2241402; rs2878419; rs3846662; rs3846661; rs10942735; rs3846663; rs6453131; rs6882842; rs17244855; rs12654264; rs7717396; rs17244841; rs17244806; rs17238596; rs17238540; rs17244862; rs10473972; rs10474434; rs17244890; rs11742194; rs10515198; rs17238477; rs17244848; rs17244883; rs17238449; rs17244834; rs2303152; rs17244813; rs17238484; rs3064877; rs11957984; rs10053643; rs17238435; rs2303151; rs17238456; rs17238603; rs35767444; rs17238575; rs17238589; rs17244897; rs17244827; rs10063134; rs35635349; rs3843482; rs17238519; rs17238498; rs17244792; rs17244799; rs17244960; rs17244785; rs17238442; rs17244876; rs4629571; rs3761739; rs17244953; rs17238337; rs17238330; rs17244708; rs3761738; rs3761740; rs17244946; rs17244715; rs34652146; rs34334938; rs35436905; rs35561739; rs36010179; rs1044453; rs11402730; rs35855355; rs34198674; rs11453557; rs12657545; rs35306582; rs10683134; rs11379632; rs17648121; rs33988510; rs11443896; rs10590407; rs2898551; rs3064191; rs35744174; rs35152895; rs35491024; rs33926107; rs13436857; rs11743717; rs11749783; rs11957619; rs16872521; rs16872523; rs3180743; rs35176659; rs3733907; rs3761741; rs3843480; rs3843481; rs3931914; rs4703670; rs4704209; rs7703051

# Macromolecular_Interacting_Partner_9_General_References:
2991281; 10698924; 10391209

# Macromolecular_Interacting_Partner_9_References:
16936198; 16955138; 17002594; 17008555

# Macromolecular_Interacting_Partner_10_ID:
7562

# Macromolecular_Interacting_Partner_10_Name:
Apolipoprotein B-100 precursor

# Macromolecular_Interacting_Partner_10_Synonyms:
Apo B-100[Contains: Apolipoprotein B-48; Apo B-48]

# Macromolecular_Interacting_Partner_10_Gene_Name:
APOB

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Apolipoprotein B100 precursor
MDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAES
SSGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSE
EFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLFLD
TVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLIS
SSQSCQYTLDAKRKHVAEAICKEQHLFLPFSYNNKYGMVAQVTQTLKLEDTPKINSRFFG
EGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGLSD
EAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPE
PSAQQLREIFNMARDQRSRATLYALSHAVNNYHKTNPTGTQELLDIANYLMEQIQDDCTG
DEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKDKD
QEVLLQTFLDDASPGDKRLAAYLMLMRSPSQADINKIVQILPWEQNEQVKNFVASHIANI
LNSEELDIQDLKKLVKEALKESQLPTVMDFRKFSRNYQLYKSVSLPSLDPASAKIEGNLI
FDPNNYLPKESMLKTTLTAFGFASADLIEIGLEGKGFEPTLEALFGKQGFFPDSVNKALY
WVNGQVPDGVSKVLVDHFGYTKDDKHEQDMVNGIMLSVEKLIKDLKSKEVPEARAYLRIL
GEELGFASLHDLQLLGKLLLMGARTLQGIPQMIGEVIRKGSKNDFFLHYIFMENAFELPT
GAGLQLQISSSGVIAPGAKAGVKLEVANMQAELVAKPSVSVEFVTNMGIIIPDFARSGVQ
MNTNFFHESGLEAHVALKAGKLKFIIPSPKRPVKLLSGGNTLHLVSTTKTEVIPPLIENR
QSWSVCKQVFPGLNYCTSGAYSNASSTDSASYYPLTGDTRLELELRPTGEIEQYSVSATY
ELQREDRALVDTLKFVTQAEGAKQTEATMTFKYNRQSMTLSSEVQIPDFDVDLGTILRVN
DESTEGKTSYRLTLDIQNKKITEVALMGHLSCDTKEERKIKGVISIPRLQAEARSEILAH
WSPAKLLLQMDSSATAYGSTVSKRVAWHYDEEKIEFEWNTGTNVDTKKMTSNFPVDLSDY
PKSLHMYANRLLDHRVPETDMTFRHVGSKLIVAMSSWLQKASGSLPYTQTLQDHLNSLKE
FNLQNMGLPDFHIPENLFLKSDGRVKYTLNKNSLKIEIPLPFGGKSSRDLKMLETVRTPA
LHFKSVGFHLPSREFQVPTFTIPKLYQLQVPLLGVLDLSTNVYSNLYNWSASYSGGNTST
DHFSLRARYHMKADSVVDLLSYNVQGSGETTYDHKNTFTLSCDGSLRHKFLDSNIKFSHV
EKLGNNPVSKGLLIFDASSSWGPQMSASVHLDSKKKQHLFVKEVKIDGQFRVSSFYAKGT
YGLSCQRDPNTGRLNGESNLRFNSSYLQGTNQITGRYEDGTLSLTSTSDLQSGIIKNTAS
LKYENYELTLKSDTNGKYKNFATSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLN
SHGLELNADILGTDKINSGAHKATLRIGQDGISTSATTNLKCSLLVLENELNAELGLSGA
SMKLTTNGRFREHNAKFSLDGKAALTELSLGSAYQAMILGVDSKNIFNFKVSQEGLKLSN
DMMGSYAEMKFDHTNSLNIAGLSLDFSSKLDNIYSSDKFYKQTVNLQLQPYSLVTTLNSD
LKYNALDLTNNGKLRLEPLKLHVAGNLKGAYQNNEIKHIYAISSAALSASYKADTVAKVQ
GVEFSHRLNTDIAGLASAIDMSTNYNSDSLHFSNVFRSVMAPFTMTIDAHTNGNGKLALW
GEHTGQLYSKFLLKAEPLAFTFSHDYKGSTSHHLVSRKSISAALEHKVSALLTPAEQTGT
WKLKTQFNNNEYSQDLDAYNTKDKIGVELTGRTLADLTLLDSPIKVPLLLSEPINIIDAL
EMRDAVEKPQEFTIVAFVKYDKNQDVHSINLPFFETLQEYFERNRQTIIVVVENVQRNLK
HINIDQFVRKYRAALGKLPQQANDYLNSFNWERQVSHAKEKLTALTKKYRITENDIQIAL
DDAKINFNEKLSQLQTYMIQFDQYIKDSYDLHDLKIAIANIIDEIIEKLKSLDEHYHIRV
NLVKTIHDLHLFIENIDFNKSGSSTASWIQNVDTKYQIRIQIQEKLQQLKRHIQNIDIQH
LAGKLKQHIEAIDVRVLLDQLGTTISFERINDVLEHVKHFVINLIGDFEVAEKINAFRAK
VHELIERYEVDQQIQVLMDKLVELTHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDA
VKKLNELSFKTFIEDVNKFLDMLIKKLKSFDYHQFVDETNDKIREVTQRLNGEIQALELP
QKAEALKLFLEETKATVAVYLESLQDTKITLIINWLQEALSSASLAHMKAKFRETLEDTR
DRMYQMDIQQELQRYLSLVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRMKAL
VEQGFTVPEIKTILGTMPAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKDLKNIK
IPSRFSTPEFTILNTFHIPSFTIDFVEMKVKIIRTIDQMQNSELQWPVPDIYLRDLKVED
IPLARITLPDFRLPEIAIPEFIIPTLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYS
ILKIQSPLFTLDANADIGNGTTSANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKIN
PLALKESVKFSSKYLRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNGVIVKINNQ
LTLDSNTKYFHKLNIPKLDFSSQADLRNEIKTLLKAGHIAWTSSGKGSWKWACPRFSDEG
THESQISFTIEGPLTSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHS
VLTAKGMALFGEGKAEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVRF
PLRLTGKIDFLNNYALFLSPSAQQASWQVSARFNQYKYNQNFSAGNNENIMEAHVGINGE
ANLDFLNIPLTIPEMRLPYTIITTPPLKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKN
KHRHSITNPLAVLCEFISQSIKSFDRHFEKNRNNALDFVTKSYNETKIKFDKYKAEKSHD
ELPRTFQIPGYTVPVVNVEVSPFTIEMSAFGYVFPKAVSMPSFSILGSDVRVPSYTLILP
SLELPVLHVPRNLKLSLPHFKELCTISHIFIPAMGNITYDFSFKSSVITLNTNAELFNQS
DIVAHLLSSSSSVIDALQYKLEGTTRLTRKRGLKLATALSLSNKFVEGSHNSTVSLTTKN
MEVSVAKTTKAEIPILRMNFKQELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVDHK
LSLESLTSYFSIESSTKGDVKGSVLSREYSGTIASEANTYLNSKSTRSSVKLQGTSKIDD
IWNLEVKENFAGEATLQRIYSLWEHSTKNHLQLEGLFFTNGEHTSKATLELSPWQMSALV
QVHASQPSSFHDFPDLGQEVALNANTKNQKIRWKNEVRIHSGSFQSQVELSNDQEKAHLD
IAGSLEGHLRFLKNIILPVYDKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPNGYSFS
IPVKVLADKFITPGLKLNDLNSVLVMPTFHVPFTDLQVPSCKLDFREIQIYKKLRTSSFA
LNLPTLPEVKFPEVDVLTKYSQPEDSLIPFFEITVPESQLTVSQFTLPKSVSDGIAALDL
NAVANKIADFELPTIIVPEQTIEIPSIKFSVPAGIVIPSFQALTARFEVDSPVYNATWSA
SLKNKADYVETVLDSTCSSTVQFLEYELNVLGTHKIEDGTLASKTKGTLAHRDFSAEYEE
DGKFEGLQEWEGKAHLNIKSPAFTDLHLRYQKDKKGISTSAASPAVGTVGMDMDEDDDFS
KWNFYYSPQSSPDKKLTIFKTELRVRESDEETQIKVNWEEEAASGLLTSLKDNVPKATGV
LYDYVNKYHWEHTGLTLREVSSKLRRNLQNNAEWVYQGAIRQIDDIDVRFQKAASGTTGT
YQEWKDKAQNLYQELLTQEGQASFQGLKDNVFDGLVRVTQKFHMKVKHLIDSLIDFLNFP
RFQFPGKPGIYTREELCTMFIREVGTVLSQVYSKVHNGSEILFSYFQDLVITLPFELRKH
KLIDVISMYRELLKDLSKEAQEVFKAIQSLKTTEVLRNLQDLLQFIFQLIEDNIKQLKEM
KFTYLINYIQDEINTIFNDYIPYVFKLLKENLCLNLHKFNEFIQNELQEASQELQQIHQY
IMALREEYFDPSIVGWTVKYYELEEKIVSLIKNLLVALKDFHSEYIVSASNFTSQLSSQV
EQFLHRNIQEYLSILTDPDGKGKEKIAELSATAQEIIKSQAIATKKIISDYHQQFRYKLQ
DFSDQLSDYYEKFIAESKRLIDLSIQNYHTFLIYITELLKKLQSTTVMNPYMKLAPGELT
IIL

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
4563

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
515568

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
7.06

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  transporter activity
Function:  lipid transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  lipid transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_10_General_Function:
Replication, recombination and repair 

# Macromolecular_Interacting_Partner_10_Specific_Function:
Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF06448:DUF1081;
PF09172:DUF1943;
PF01347:Vitellogenin_N

# Macromolecular_Interacting_Partner_10_Signals:
1-27

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
34331

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
APOB_HUMAN (P04114)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
APOB

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
APOB

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:603

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>13692 bp
ATGGACCCGCCGAGGCCCGCGCTGCTGGCGCTGCTGGCGCTGCCTGCGCTGCTGCTGCTG
CTGCTGGCGGGCGCCAGGGCCGAAGAGGAAATGCTGGAAAATGTCAGCCTGGTCTGTCCA
AAAGATGCGACCCGATTCAAGCACCTCCGGAAGTACACATACAACTATGAGGCTGAGAGT
TCCAGTGGAGTCCCTGGGACTGCTGATTCAAGAAGTGCCACCAGGATCAACTGCAAGGTT
GAGCTGGAGGTTCCCCAGCTCTGCAGCTTCATCCTGAAGACCAGCCAGTGCACCCTGAAA
GAGGTGTATGGCTTCAACCCTGAGGGCAAAGCCTTGCTGAAGAAAACCAAGAACTCTGAG
GAGTTTGCTGCAGCCATGTCCAGGTATGAGCTCAAGCTGGCCATTCCAGAAGGGAAGCAG
GTTTTCCTTTACCCGGAGAAAGATGAACCTACTTACATCCTGAACATCAAGAGGGGCATC
ATTTCTGCCCTCCTGGTTCCCCCAGAGACAGAAGAAGCCAAGCAAGTGTTGTTTCTGGAT
ACCGTGTATGGAAACTGCTCCACTCACTTTACCGTCAAGACGAGGAAGGGCAATGTGGCA
ACAGAAATATCCACTGAAAGAGACCTGGGGCAGTGTGATCGCTTCAAGCCCATCCGCACA
GGCATCAGCCCACTTGCTCTCATCAAAGGCATGACCCGCCCCTTGTCAACTCTGATCAGC
AGCAGCCAGTCCTGTCAGTACACACTGGACGCTAAGAGGAAGCATGTGGCAGAAGCCATC
TGCAAGGAGCAACACCTCTTCCTGCCTTTCTCCTACAACAATAAGTATGGGATGGTAGCA
CAAGTGACACAGACTTTGAAACTTGAAGACACACCAAAGATCAACAGCCGCTTCTTTGGT
GAAGGTACTAAGAAGATGGGCCTCGCATTTGAGAGCACCAAATCCACATCACCTCCAAAG
CAGGCCGAAGCTGTTTTGAAGACTCTCCAGGAACTGAAAAAACTAACCATCTCTGAGCAA
AATATCCAGAGAGCTAATCTCTTCAATAAGCTGGTTACTGAGCTGAGAGGCCTCAGTGAT
GAAGCAGTCACATCTCTCTTGCCACAGCTGATTGAGGTGTCCAGCCCCATCACTTTACAA
GCCTTGGTTCAGTGTGGACAGCCTCAGTGCTCCACTCACATCCTCCAGTGGCTGAAACGT
GTGCATGCCAACCCCCTTCTGATAGATGTGGTCACCTACCTGGTGGCCCTGATCCCCGAG
CCCTCAGCACAGCAGCTGCGAGAGATCTTCAACATGGCGAGGGATCAGCGCAGCCGAGCC
ACCTTGTATGCGCTGAGCCACGCGGTCAACAACTATCATAAGACAAACCCTACAGGGACC
CAGGAGCTGCTGGACATTGCTAATTACCTGATGGAACAGATTCAAGATGACTGCACTGGG
GATGAAGATTACACCTATTTGATTCTGCGGGTCATTGGAAATATGGGCCAAACCATGGAG
CAGTTAACTCCAGAACTCAAGTCTTCAATCCTCAAATGTGTCCAAAGTACAAAGCCATCA
CTGATGATCCAGAAAGCTGCCATCCAGGCTCTGCGGAAAATGGAGCCTAAAGACAAGGAC
CAGGAGGTTCTTCTTCAGACTTTCCTTGATGATGCTTCTCCGGGAGATAAGCGACTGGCT
GCCTATCTTATGTTGATGAGGAGTCCTTCACAGGCAGATATTAACAAAATTGTCCAAATT
CTACCATGGGAACAGAATGAGCAAGTGAAGAACTTTGTGGCTTCCCATATTGCCAATATC
TTGAACTCAGAAGAATTGGATATCCAAGATCTGAAAAAGTTAGTGAAAGAAGCTCTGAAA
GAATCTCAACTTCCAACTGTCATGGACTTCAGAAAATTCTCTCGGAACTATCAACTCTAC
AAATCTGTTTCTCTTCCATCACTTGACCCAGCCTCAGCCAAAATAGAAGGGAATCTTATA
TTTGATCCAAATAACTACCTTCCTAAAGAAAGCATGCTGAAAACTACCCTCACTGCCTTT
GGATTTGCTTCAGCTGACCTCATCGAGATTGGCTTGGAAGGAAAAGGCTTTGAGCCAACA
TTGGAAGCTCTTTTTGGGAAGCAAGGATTTTTCCCAGACAGTGTCAACAAAGCTTTGTAC
TGGGTTAATGGTCAAGTTCCTGATGGTGTCTCTAAGGTCTTAGTGGACCACTTTGGCTAT
ACCAAAGATGATAAACATGAGCAGGATATGGTAAATGGAATAATGCTCAGTGTTGAGAAG
CTGATTAAAGATTTGAAATCCAAAGAAGTCCCGGAAGCCAGAGCCTACCTCCGCATCTTG
GGAGAGGAGCTTGGTTTTGCCAGTCTCCATGACCTCCAGCTCCTGGGAAAGCTGCTTCTG
ATGGGTGCCCGCACTCTGCAGGGGATCCCCCAGATGATTGGAGAGGTCATCAGGAAGGGC
TCAAAGAATGACTTTTTTCTTCACTACATCTTCATGGAGAATGCCTTTGAACTCCCCACT
GGAGCTGGATTACAGTTGCAAATATCTTCATCTGGAGTCATTGCTCCCGGAGCCAAGGCT
GGAGTAAAACTGGAAGTAGCCAACATGCAGGCTGAACTGGTGGCAAAACCCTCCGTGTCT
GTGGAGTTTGTGACAAATATGGGCATCATCATTCCGGACTTCGCTAGGAGTGGGGTCCAG
ATGAACACCAACTTCTTCCACGAGTCGGGTCTGGAGGCTCATGTTGCCCTAAAAGCTGGG
AAGCTGAAGTTTATCATTCCTTCCCCAAAGAGACCAGTCAAGCTGCTCAGTGGAGGCAAC
ACATTACATTTGGTCTCTACCACCAAAACGGAGGTGATCCCACCTCTCATTGAGAACAGG
CAGTCCTGGTCAGTTTGCAAGCAAGTCTTTCCTGGCCTGAATTACTGCACCTCAGGCGCT
TACTCCAACGCCAGCTCCACAGACTCCGCCTCCTACTATCCGCTGACCGGGGACACCAGA
TTAGAGCTGGAACTGAGGCCTACAGGAGAGATTGAGCAGTATTCTGTCAGCGCAACCTAT
GAGCTCCAGAGAGAGGACAGAGCCTTGGTGGATACCCTGAAGTTTGTAACTCAAGCAGAA
GGTGCGAAGCAGACTGAGGCTACCATGACATTCAAATATAATCGGCAGAGTATGACCTTG
TCCAGTGAAGTCCAAATTCCGGATTTTGATGTTGACCTCGGAACAATCCTCAGAGTTAAT
GATGAATCTACTGAGGGCAAAACGTCTTACAGACTCACCCTGGACATTCAGAACAAGAAA
ATTACTGAGGTCGCCCTCATGGGCCACCTAAGTTGTGACACAAAGGAAGAAAGAAAAATC
AAGGGTGTTATTTCCATACCCCGTTTGCAAGCAGAAGCCAGAAGTGAGATCCTCGCCCAC
TGGTCGCCTGCCAAACTGCTTCTCCAAATGGACTCATCTGCTACAGCTTATGGCTCCACA
GTTTCCAAGAGGGTGGCATGGCATTATGATGAAGAGAAGATTGAATTTGAATGGAACACA
GGCACCAATGTAGATACCAAAAAAATGACTTCCAATTTCCCTGTGGATCTCTCCGATTAT
CCTAAGAGCTTGCATATGTATGCTAATAGACTCCTGGATCACAGAGTCCCTGAAACAGAC
ATGACTTTCCGGCACGTGGGTTCCAAATTAATAGTTGCAATGAGCTCATGGCTTCAGAAG
GCATCTGGGAGTCTTCCTTATACCCAGACTTTGCAAGACCACCTCAATAGCCTGAAGGAG
TTCAACCTCCAGAACATGGGATTGCCAGACTTCCACATCCCAGAAAACCTCTTCTTAAAA
AGCGATGGCCGGGTCAAATATACCTTGAACAAGAACAGTTTGAAAATTGAGATTCCTTTG
CCTTTTGGTGGCAAATCCTCCAGAGATCTAAAGATGTTAGAGACTGTTAGGACACCAGCC
CTCCACTTCAAGTCTGTGGGATTCCATCTGCCATCTCGAGAGTTCCAAGTCCCTACTTTT
ACCATTCCCAAGTTGTATCAACTGCAAGTGCCTCTCCTGGGTGTTCTAGACCTCTCCACG
AATGTCTACAGCAACTTGTACAACTGGTCCGCCTCCTACAGTGGTGGCAACACCAGCACA
GACCATTTCAGCCTTCGGGCTCGTTACCACATGAAGGCTGACTCTGTGGTTGACCTGCTT
TCCTACAATGTGCAAGGATCTGGAGAAACAACATATGACCACAAGAATACGTTCACACTA
TCATGTGATGGGTCTCTACGCCACAAATTTCTAGATTCGAATATCAAATTCAGTCATGTA
GAAAAACTTGGAAACAACCCAGTCTCAAAAGGTTTACTAATATTCGATGCATCTAGTTCC
TGGGGACCACAGATGTCTGCTTCAGTTCATTTGGACTCCAAAAAGAAACAGCATTTGTTT
GTCAAAGAAGTCAAGATTGATGGGCAGTTCAGAGTCTCTTCGTTCTATGCTAAAGGCACA
TATGGCCTGTCTTGTCAGAGGGATCCTAACACTGGCCGGCTCAATGGAGAGTCCAACCTG
AGGTTTAACTCCTCCTACCTCCAAGGCACCAACCAGATAACAGGAAGATATGAAGATGGA
ACCCTCTCCCTCACCTCCACCTCTGATCTGCAAAGTGGCATCATTAAAAATACTGCTTCC
CTAAAGTATGAGAACTACGAGCTGACTTTAAAATCTGACACCAATGGGAAGTATAAGAAC
TTTGCCACTTCTAACAAGATGGATATGACCTTCTCTAAGCAAAATGCACTGCTGCGTTCT
GAATATCAGGCTGATTACGAGTCATTGAGGTTCTTCAGCCTGCTTTCTGGATCACTAAAT
TCCCATGGTCTTGAGTTAAATGCTGACATCTTAGGCACTGACAAAATTAATAGTGGTGCT
CACAAGGCGACACTAAGGATTGGCCAAGATGGAATATCTACCAGTGCAACGACCAACTTG
AAGTGTAGTCTCCTGGTGCTGGAGAATGAGCTGAATGCAGAGCTTGGCCTCTCTGGGGCA
TCTATGAAATTAACAACAAATGGCCGCTTCAGGGAACACAATGCAAAATTCAGTCTGGAT
GGGAAAGCCGCCCTCACAGAGCTATCACTGGGAAGTGCTTATCAGGCCATGATTCTGGGT
GTCGACAGCAAAAACATTTTCAACTTCAAGGTCAGTCAAGAAGGACTTAAGCTCTCAAAT
GACATGATGGGCTCATATGCTGAAATGAAATTTGACCACACAAACAGTCTGAACATTGCA
GGCTTATCACTGGACTTCTCTTCAAAACTTGACAACATTTACAGCTCTGACAAGTTTTAT
AAGCAAACTGTTAATTTACAGCTACAGCCCTATTCTCTGGTAACTACTTTAAACAGTGAC
CTGAAATACAATGCTCTGGATCTCACCAACAATGGGAAACTACGGCTAGAACCCCTGAAG
CTGCATGTGGCTGGTAACCTAAAAGGAGCCTACCAAAATAATGAAATAAAACACATCTAT
GCCATCTCTTCTGCTGCCTTATCAGCAAGCTATAAAGCAGACACTGTTGCTAAGGTTCAG
GGTGTGGAGTTTAGCCATCGGCTCAACACAGACATCGCTGGGCTGGCTTCAGCCATTGAC
ATGAGCACAAACTATAATTCAGACTCACTGCATTTCAGCAATGTCTTCCGTTCTGTAATG
GCCCCGTTTACCATGACCATCGATGCACATACAAATGGCAATGGGAAACTCGCTCTCTGG
GGAGAACATACTGGGCAGCTGTATAGCAAATTCCTGTTGAAAGCAGAACCTCTGGCATTT
ACTTTCTCTCATGATTACAAAGGCTCCACAAGTCATCATCTCGTGTCTAGGAAAAGCATC
AGTGCAGCTCTTGAACACAAAGTCAGTGCCCTGCTTACTCCAGCTGAGCAGACAGGCACC
TGGAAACTCAAGACCCAATTTAACAACAATGAATACAGCCAGGACTTGGATGCTTACAAC
ACTAAAGATAAAATTGGCGTGGAGCTTACTGGACGAACTCTGGCTGACCTAACTCTACTA
GACTCCCCAATTAAAGTGCCACTTTTACTCAGTGAGCCCATCAATATCATTGATGCTTTA
GAGATGAGAGATGCCGTTGAGAAGCCCCAAGAATTTACAATTGTTGCTTTTGTAAAGTAT
GATAAAAACCAAGATGTTCACTCCATTAACCTCCCATTTTTTGAGACCTTGCAAGAATAT
TTTGAGAGGAATCGACAAACCATTATAGTTGTAGTGGAAAACGTACAGAGAAACCTGAAG
CACATCAATATTGATCAATTTGTAAGAAAATACAGAGCAGCCCTGGGAAAACTCCCACAG
CAAGCTAATGATTATCTGAATTCATTCAATTGGGAGAGACAAGTTTCACATGCCAAGGAG
AAACTGACTGCTCTCACAAAAAAGTATAGAATTACAGAAAATGATATACAAATTGCATTA
GATGATGCCAAAATCAACTTTAATGAAAAACTATCTCAACTGCAGACATATATGATACAA
TTTGATCAGTATATTAAAGATAGTTATGATTTACATGATTTGAAAATAGCTATTGCTAAT
ATTATTGATGAAATCATTGAAAAATTAAAAAGTCTTGATGAGCACTATCATATCCGTGTA
AATTTAGTAAAAACAATCCATGATCTACATTTGTTTATTGAAAATATTGATTTTAACAAA
AGTGGAAGTAGTACTGCATCCTGGATTCAAAATGTGGATACTAAGTACCAAATCAGAATC
CAGATACAAGAAAAACTGCAGCAGCTTAAGAGACACATACAGAATATAGACATCCAGCAC
CTAGCTGGAAAGTTAAAACAACACATTGAGGCTATTGATGTTAGAGTGCTTTTAGATCAA
TTGGGAACTACAATTTCATTTGAAAGAATAAATGATGTTCTTGAGCATGTCAAACACTTT
GTTATAAATCTTATTGGGGATTTTGAAGTAGCTGAGAAAATCAATGCCTTCAGAGCCAAA
GTCCATGAGTTAATCGAGAGGTATGAAGTAGACCAACAAATCCAGGTTTTAATGGATAAA
TTAGTAGAGTTGACCCACCAATACAAGTTGAAGGAGACTATTCAGAAGCTAAGCAATGTC
CTACAACAAGTTAAGATAAAAGATTACTTTGAGAAATTGGTTGGATTTATTGATGATGCT
GTGAAGAAGCTTAATGAATTATCTTTTAAAACATTCATTGAAGATGTTAACAAATTCCTT
GACATGTTGATAAAGAAATTAAAGTCATTTGATTACCACCAGTTTGTAGATGAAACCAAT
GACAAAATCCGTGAGGTGACTCAGAGACTCAATGGTGAAATTCAGGCTCTGGAACTACCA
CAAAAAGCTGAAGCATTAAAACTGTTTTTAGAGGAAACCAAGGCCACAGTTGCAGTGTAT
CTGGAAAGCCTACAGGACACCAAAATAACCTTAATCATCAATTGGTTACAGGAGGCTTTA
AGTTCAGCATCTTTGGCTCACATGAAGGCCAAATTCCGAGAGACTCTAGAAGATACACGA
GACCGAATGTATCAAATGGACATTCAGCAGGAACTTCAACGATACCTGTCTCTGGTAGGC
CAGGTTTATAGCACACTTGTCACCTACATTTCTGATTGGTGGACTCTTGCTGCTAAGAAC
CTTACTGACTTTGCAGAGCAATATTCTATCCAAGATTGGGCTAAACGTATGAAAGCATTG
GTAGAGCAAGGGTTCACTGTTCCTGAAATCAAGACCATCCTTGGGACCATGCCTGCCTTT
GAAGTCAGTCTTCAGGCTCTTCAGAAAGCTACCTTCCAGACACCTGATTTTATAGTCCCC
CTAACAGATTTGAGGATTCCATCAGTTCAGATAAACTTCAAAGACTTAAAAAATATAAAA
ATCCCATCCAGGTTTTCCACACCAGAATTTACCATCCTTAACACCTTCCACATTCCTTCC
TTTACAATTGACTTTGTCGAAATGAAAGTAAAGATCATCAGAACCATTGACCAGATGCAG
AACAGTGAGCTGCAGTGGCCCGTTCCAGATATATATCTCAGGGATCTGAAGGTGGAGGAC
ATTCCTCTAGCGAGAATCACCCTGCCAGACTTCCGTTTACCAGAAATCGCAATTCCAGAA
TTCATAATCCCAACTCTCAACCTTAATGATTTTCAAGTTCCTGACCTTCACATACCAGAA
TTCCAGCTTCCCCACATCTCACACACAATTGAAGTACCTACTTTTGGCAAGCTATACAGT
ATTCTGAAAATCCAATCTCCTCTTTTCACATTAGATGCAAATGCTGACATAGGGAATGGA
ACCACCTCAGCAAACGAAGCAGGTATCGCAGCTTCCATCACTGCCAAAGGAGAGTCCAAA
TTAGAAGTTCTCAATTTTGATTTTCAAGCAAATGCACAACTCTCAAACCCTAAGATTAAT
CCGCTGGCTCTGAAGGAGTCAGTGAAGTTCTCCAGCAAGTACCTGAGAACGGAGCATGGG
AGTGAAATGCTGTTTTTTGGAAATGCTATTGAGGGAAAATCAAACACAGTGGCAAGTTTA
CACACAGAAAAAAATACACTGGAGCTTAGTAATGGAGTGATTGTCAAGATAAACAATCAG
CTTACCCTGGATAGCAACACTAAATACTTCCACAAATTGAACATCCCCAAACTGGACTTC
TCTAGTCAGGCTGACCTGCGCAACGAGATCAAGACACTGTTGAAAGCTGGCCACATAGCA
TGGACTTCTTCTGGAAAAGGGTCATGGAAATGGGCCTGCCCCAGATTCTCAGATGAGGGA
ACACATGAATCACAAATTAGTTTCACCATAGAAGGACCCCTCACTTCCTTTGGACTGTCC
AATAAGATCAATAGCAAACACCTAAGAGTAAACCAAAACTTGGTTTATGAATCTGGCTCC
CTCAACTTTTCTAAACTTGAAATTCAATCACAAGTCGATTCCCAGCATGTGGGCCACAGT
GTTCTAACTGCTAAAGGCATGGCACTGTTTGGAGAAGGGAAGGCAGAGTTTACTGGGAGG
CATGATGCTCATTTAAATGGAAAGGTTATTGGAACTTTGAAAAATTCTCTTTTCTTTTCA
GCCCAGCCATTTGAGATCACGGCATCCACAAACAATGAAGGGAATTTGAAAGTTCGTTTT
CCATTAAGGTTAACAGGGAAGATAGACTTCCTGAATAACTATGCACTGTTTCTGAGTCCC
AGTGCCCAGCAAGCAAGTTGGCAAGTAAGTGCTAGGTTCAATCAGTATAAGTACAACCAA
AATTTCTCTGCTGGAAACAACGAGAACATTATGGAGGCCCATGTAGGAATAAATGGAGAA
GCAAATCTGGATTTCTTAAACATTCCTTTAACAATTCCTGAAATGCGTCTACCTTACACA
ATAATCACAACTCCTCCACTGAAAGATTTCTCTCTATGGGAAAAAACAGGCTTGAAGGAA
TTCTTGAAAACGACAAAGCAATCATTTGATTTAAGTGTAAAAGCTCAGTATAAGAAAAAC
AAACACAGGCATTCCATCACAAATCCTTTGGCTGTGCTTTGTGAGTTTATCAGTCAGAGC
ATCAAATCCTTTGACAGGCATTTTGAAAAAAACAGAAACAATGCATTAGATTTTGTCACC
AAATCCTATAATGAAACAAAAATTAAGTTTGATAAGTACAAAGCTGAAAAATCTCACGAC
GAGCTCCCCAGGACCTTTCAAATTCCTGGATACACTGTTCCAGTTGTCAATGTTGAAGTG
TCTCCATTCACCATAGAGATGTCGGCATTCGGCTATGTGTTCCCAAAAGCAGTCAGCATG
CCTAGTTTCTCCATCCTAGGTTCTGACGTCCGTGTGCCTTCATACACATTAATCCTGCCA
TCATTAGAGCTGCCAGTCCTTCATGTCCCTAGAAATCTCAAGCTTTCTCTTCCACATTTC
AAGGAATTGTGTACCATAAGCCATATTTTTATTCCTGCCATGGGCAATATTACCTATGAT
TTCTCCTTTAAATCAAGTGTCATCACACTGAATACCAATGCTGAACTTTTTAACCAGTCA
GATATTGTTGCTCATCTCCTTTCTTCATCTTCATCTGTCATTGATGCACTGCAGTACAAA
TTAGAGGGCACCACAAGATTGACAAGAAAAAGGGGATTGAAGTTAGCCACAGCTCTGTCT
CTGAGCAACAAATTTGTGGAGGGTAGTCATAACAGTACTGTGAGCTTAACCACGAAAAAT
ATGGAAGTGTCAGTGGCAAAAACCACAAAAGCCGAAATTCCAATTTTGAGAATGAATTTC
AAGCAAGAACTTAATGGAAATACCAAGTCAAAACCTACTGTCTCTTCCTCCATGGAATTT
AAGTATGATTTCAATTCTTCAATGCTGTACTCTACCGCTAAAGGAGCAGTTGACCACAAG
CTTAGCTTGGAAAGCCTCACCTCTTACTTTTCCATTGAGTCATCTACCAAAGGAGATGTC
AAGGGTTCGGTTCTTTCTCGGGAATATTCAGGAACTATTGCTAGTGAGGCCAACACTTAC
TTGAATTCCAAGAGCACACGGTCTTCAGTGAAGCTGCAGGGCACTTCCAAAATTGATGAT
ATCTGGAACCTTGAAGTAAAAGAAAATTTTGCTGGAGAAGCCACACTCCAACGCATATAT
TCCCTCTGGGAGCACAGTACGAAAAACCACTTACAGCTAGAGGGCCTCTTTTTCACCAAC
GGAGAACATACAAGCAAAGCCACCCTGGAACTCTCTCCATGGCAAATGTCAGCTCTTGTT
CAGGTCCATGCAAGTCAGCCCAGTTCCTTCCATGATTTCCCTGACCTTGGCCAGGAAGTG
GCCCTGAATGCTAACACTAAGAACCAGAAGATCAGATGGAAAAATGAAGTCCGGATTCAT
TCTGGGTCTTTCCAGAGCCAGGTCGAGCTTTCCAATGACCAAGAAAAGGCACACCTTGAC
ATTGCAGGATCCTTAGAAGGACACCTAAGGTTCCTCAAAAATATCATCCTACCAGTCTAT
GACAAGAGCTTATGGGATTTCCTAAAGCTGGATGTAACCACCAGCATTGGTAGGAGACAG
CATCTTCGTGTTTCAACTGCCTTTGTGTACACCAAAAACCCCAATGGCTATTCATTCTCC
ATCCCTGTAAAAGTTTTGGCTGATAAATTCATTACTCCTGGGCTGAAACTAAATGATCTA
AATTCAGTTCTTGTCATGCCTACGTTCCATGTCCCATTTACAGATCTTCAGGTTCCATCG
TGCAAACTTGACTTCAGAGAAATACAAATCTATAAGAAGCTGAGAACTTCATCATTTGCC
CTCAACCTACCAACACTCCCCGAGGTAAAATTCCCTGAAGTTGATGTGTTAACAAAATAT
TCTCAACCAGAAGACTCCTTGATTCCCTTTTTTGAGATAACCGTGCCTGAATCTCAGTTA
ACTGTGTCCCAGTTCACGCTTCCAAAAAGTGTTTCAGATGGCATTGCTGCTTTGGATCTA
AATGCAGTAGCCAACAAGATCGCAGACTTTGAGTTGCCCACCATCATCGTGCCTGAGCAG
ACCATTGAGATTCCCTCCATTAAGTTCTCTGTACCTGCTGGAATTGTCATTCCTTCCTTT
CAAGCACTGACTGCACGCTTTGAGGTAGACTCTCCCGTGTATAATGCCACTTGGAGTGCC
AGTTTGAAAAACAAAGCAGATTATGTTGAAACAGTCCTGGATTCCACATGCAGCTCAACC
GTACAGTTCCTAGAATATGAACTAAATGTTTTGGGAACACACAAAATCGAAGATGGTACG
TTAGCCTCTAAGACTAAAGGAACACTTGCACACCGTGACTTCAGTGCAGAATATGAAGAA
GATGGCAAATTTGAAGGACTTCAGGAATGGGAAGGAAAAGCGCACCTCAATATCAAAAGC
CCAGCGTTCACCGATCTCCATCTGCGCTACCAGAAAGACAAGAAAGGCATCTCCACCTCA
GCAGCCTCCCCAGCCGTAGGCACCGTGGGCATGGATATGGATGAAGATGACGACTTTTCT
AAATGGAACTTCTACTACAGCCCTCAGTCCTCTCCAGATAAAAAACTCACCATATTCAAA
ACTGAGTTGAGGGTCCGGGAATCTGATGAGGAAACTCAGATCAAAGTTAATTGGGAAGAA
GAGGCAGCTTCTGGCTTGCTAACCTCTCTGAAAGACAACGTGCCCAAGGCCACAGGGGTC
CTTTATGATTATGTCAACAAGTACCACTGGGAACACACAGGGCTCACCCTGAGAGAAGTG
TCTTCAAAGCTGAGAAGAAATCTGCAGAACAATGCTGAGTGGGTTTATCAAGGGGCCATT
AGGCAAATTGATGATATCGACGTGAGGTTCCAGAAAGCAGCCAGTGGCACCACTGGGACC
TACCAAGAGTGGAAGGACAAGGCCCAGAATCTGTACCAGGAACTGTTGACTCAGGAAGGC
CAAGCCAGTTTCCAGGGACTCAAGGATAACGTGTTTGATGGCTTGGTACGAGTTACTCAA
AAATTCCATATGAAAGTCAAGCATCTGATTGACTCACTCATTGATTTTCTGAACTTCCCC
AGATTCCAGTTTCCGGGGAAACCTGGGATATACACTAGGGAGGAACTTTGCACTATGTTC
ATAAGGGAGGTAGGGACGGTACTGTCCCAGGTATATTCGAAAGTCCATAATGGTTCAGAA
ATACTGTTTTCCTATTTCCAAGACCTAGTGATTACACTTCCTTTCGAGTTAAGGAAACAT
AAACTAATAGATGTAATCTCGATGTATAGGGAACTGTTGAAAGATTTATCAAAAGAAGCC
CAAGAGGTATTTAAAGCCATTCAGTCTCTCAAGACCACAGAGGTGCTACGTAATCTTCAG
GACCTTTTACAATTCATTTTCCAACTAATAGAAGATAACATTAAACAGCTGAAAGAGATG
AAATTTACTTATCTTATTAATTATATCCAAGATGAGATCAACACAATCTTCAATGATTAT
ATCCCATATGTTTTTAAATTGTTGAAAGAAAACCTATGCCTTAATCTTCATAAGTTCAAT
GAATTTATTCAAAACGAGCTTCAGGAAGCTTCTCAAGAGTTACAGCAGATCCATCAATAC
ATTATGGCCCTTCGTGAAGAATATTTTGATCCAAGTATAGTTGGCTGGACAGTGAAATAT
TATGAACTTGAAGAAAAGATAGTCAGTCTGATCAAGAACCTGTTAGTTGCTCTTAAGGAC
TTCCATTCTGAATATATTGTCAGTGCCTCTAACTTTACTTCCCAACTCTCAAGTCAAGTT
GAGCAATTTCTGCACAGAAATATTCAGGAATATCTTAGCATCCTTACCGATCCAGATGGA
AAAGGGAAAGAGAAGATTGCAGAGCTTTCTGCCACTGCTCAGGAAATAATTAAAAGCCAG
GCCATTGCGACGAAGAAAATAATTTCTGATTACCACCAGCAGTTTAGATATAAACTGCAA
GATTTTTCAGACCAACTCTCTGATTACTATGAAAAATTTATTGCTGAATCCAAAAGATTG
ATTGACCTGTCCATTCAAAACTACCACACATTTCTGATATACATCACGGAGTTACTGAAA
AAGCTGCAATCAACCACAGTCATGAACCCCTACATGAAGCTTGCTCCAGGAGAACTTACT
ATCATCCTCTAA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
X04506

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_10_Locus:
2p24-p23

# Macromolecular_Interacting_Partner_10_SNPs:
rs1367117; rs1801699; rs12713681; rs2163204; rs12713844; rs676210; rs1801703; rs12713675; rs1042034; rs12713843; rs6752026; rs12720854; rs679899; rs12713450; rs12720855; rs533617; rs12714192; rs1801695; rs12714214; rs12713559; rs12720843; rs1801701; rs1801702; rs12691202; rs1042031; rs12713540; rs12720801; rs9282603; rs584542; rs12714097; rs12720848; rs12714225; rs13306187; rs1041968; rs12720852; rs6413458; rs12720847; rs12713558; rs12713554; rs12713600; rs12713457; rs1801700; rs693; rs1799812; rs1041952; rs13306196; rs12720850; rs12713501; rs12720763; rs1800480; rs531819; rs673548; rs10205849; rs2678379; rs520354; rs12720825; rs12713771; rs12720773; rs12720781; rs12714034; rs12713911; rs3749054; rs10208524; rs12720796; rs12720832; rs12720774; rs11676704; rs579826; rs570877; rs3791980; rs12720841; rs6719207; rs661665; rs3791981; rs1800479; rs11901649; rs12720821; rs12720798; rs12714226; rs12713998; rs12714233; rs1800478; rs12720842; rs11126598; rs12720791; rs2854725; rs550619; rs12720770; rs11680233; rs12720771; rs12720813; rs12720833; rs12713799; rs12720797; rs12720812; rs1469513; rs12720844; rs12720828; rs12720795; rs12720803; rs3828293; rs12691188; rs12720851; rs10701091; rs12720783; rs12720794; rs12720808; rs12713908; rs12720826; rs12720768; rs12720782; rs12720800; rs12714221; rs12720814; rs12720762; rs12720849; rs497166; rs12720805; rs11902466; rs12720802; rs12720785; rs12714252; rs12720836; rs12714102; rs12714224; rs12720792; rs9282605; rs12720834; rs12720840; rs12720853; rs12720845; rs12720829; rs12720822; rs12720807; rs12720788; rs12720778; rs12713523; rs12720838; rs12720804; rs12713917; rs12720787; rs12714254; rs12720799; rs12713997; rs12720823; rs12714189; rs12720827; rs12720765; rs12713956; rs12714245; rs6729524; rs10199768; rs12720820; rs12713870; rs597331; rs12720789; rs12714264; rs12720839; rs12720772; rs12720810; rs12720779; rs12720793; rs12713868; rs12720767; rs12720815; rs488329; rs768226; rs12720811; rs12720764; rs12720817; rs12720758; rs12720759; rs9282604; rs12720786; rs12720769; rs12720816; rs13306197; rs768227; rs12714239; rs12720846; rs12720835; rs12714269; rs12713869; rs12720761; rs12714268; rs12714215; rs12713776; rs12720830; rs12720790; rs6727706; rs12714216; rs12720818; rs12720777; rs12714222; rs12714238; rs12713871; rs12720780; rs12714248; rs12714247; rs12720766; rs12720819; rs12720831; rs617314; rs1800481; rs512535; rs934197; rs6547925; rs12713429; rs11883541; rs9282606; rs9282608; rs9282607; rs11687484; rs1041971; rs1042021; rs1042013; rs4362589; rs1801696; rs35708286; rs1800476; rs13306194; rs41288783; rs13306206; rs1042027; rs1126468; rs1801694; rs535237; rs1041960; rs13306191; rs1042025; rs5742904; rs568413; rs13306190; rs1042022; rs13306198; rs1864423; rs13306204; rs1801698; rs1042023; rs1801697; rs1041956; rs1041962; rs13306192; rs13306195; rs1042006; rs13306188; rs13306200; rs1041974; rs13306203; rs13306193; rs2854726; rs10595692; rs34920068; rs552428; rs7589300; rs1054527; rs13306202; rs1367116; rs2000998; rs11440527; rs34519317; rs3762565; rs6413457; rs34607237; rs41291161; rs34102309; rs35442885; rs562956; rs13306205; rs2678378; rs35493179; rs9808029; rs34914206; rs41406449; rs2000997; rs11689972; rs13003321; rs35313978; rs13005150; rs35911751; rs35377456; rs3762564; rs35046475; rs34092033; rs13306201; rs34194949; rs34594011; rs1625714; rs10635819; rs35239349; rs1625764; rs34557689; rs13306199; rs34469176; rs1560357; rs35068532; rs35621726; rs10184191; rs10197075; rs11889738; rs11891086; rs11892073; rs11893021; rs12467932; rs12468735; rs13392272; rs1713222; rs1713223; rs17398765; rs34722314; rs34776010; rs4327259; rs4371387; rs547186; rs585967; rs588245; rs589566; rs6725189; rs6756501; rs7575840; rs952274; rs952275

# Macromolecular_Interacting_Partner_10_General_References:
3763409; 3652907; 3759943; 3464946; 3030729; 3461454; 3513177; 2115173; 3001697; 3860836; 6373369; 2567736; 2883086; 3676265; 3841204; 3621347; 2450346; 3426612; 2445342; 3903660; 2994225; 2932736; 3841481; 3024665; 3659919; 3773997; 3087360; 10679026; 1979313; 2563166; 2216805; 7883971; 8889592; 9259199; 9490296; 12551903

# Macromolecular_Interacting_Partner_10_References:
16962684; 16980816; 17009078; 17030687

# Macromolecular_Interacting_Partner_11_ID:
7569

# Macromolecular_Interacting_Partner_11_Name:
Interleukin-6 precursor

# Macromolecular_Interacting_Partner_11_Synonyms:
IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF

# Macromolecular_Interacting_Partner_11_Gene_Name:
IL6

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Interleukin6 precursor
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYI
LDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLL
EFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQ
AQNQWLQDMTTHLILRSFKEFLQSSLRALRQM

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
212

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
23718

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
6.52

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interleukin-6 receptor binding
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_11_General_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Specific_Function:
IL-6 is a cytokine with a wide variety of biological functions:it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF00489:IL6

# Macromolecular_Interacting_Partner_11_Signals:
1-29

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
32674

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
IL6_HUMAN (P05231)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
IL6

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
IL6

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:6018

# Macromolecular_Interacting_Partner_11_PDB_ID:
2IL6

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>639 bp
ATGAACTCCTTCTCCACAAGCGCCTTCGGTCCAGTTGCCTTCTCCCTGGGGCTGCTCCTG
GTGTTGCCTGCTGCCTTCCCTGCCCCAGTACCCCCAGGAGAAGATTCCAAAGATGTAGCC
GCCCCACACAGACAGCCACTCACCTCTTCAGAACGAATTGACAAACAAATTCGGTACATC
CTCGACGGCATCTCAGCCCTGAGAAAGGAGACATGTAACAAGAGTAACATGTGTGAAAGC
AGCAAAGAGGCACTGGCAGAAAACAACCTGAACCTTCCAAAGATGGCTGAAAAAGATGGA
TGCTTCCAATCTGGATTCAATGAGGAGACTTGCCTGGTGAAAATCATCACTGGTCTTTTG
GAGTTTGAGGTATACCTAGAGTACCTCCAGAACAGATTTGAGAGTAGTGAGGAACAAGCC
AGAGCTGTCCAGATGAGTACAAAAGTCCTGATCCAGTTCCTGCAGAAAAAGGCAAAGAAT
CTAGATGCAATAACCACCCCTGACCCAACCACAAATGCCAGCCTGCTGACGAAGCTGCAG
GCACAGAACCAGTGGCTGCAGGACATGACAACTCATCTCATTCTGCGCAGCTTTAAGGAG
TTCCTGCAGTCCAGCCTGAGGGCTCTTCGGCAAATGTAG

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
X04430

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_11_Locus:
7p21

# Macromolecular_Interacting_Partner_11_SNPs:
rs2069860; rs13306435; rs2069830; rs2069849; rs2069850; rs2069851; rs13306436; rs2069857; rs3087226; rs1474347; rs2069833; rs2069832; rs1554606; rs2069842; rs1548216; rs2069840; rs2066992; rs1474348; rs2069835; rs2069831; rs2069845; rs2069838; rs2069834; rs2069837; rs1524107; rs2069841; rs3087232; rs13306433; rs34277345; rs2069847; rs3087227; rs2069848; rs35361244; rs34249410; rs3087228; rs3087233; rs3087230; rs2069843; rs3087229; rs2069844; rs3087231; rs2069858; rs1800795; rs2069824; rs1800797; rs7802308; rs1800796; rs7802307; rs2069829; rs3087223; rs2069827; rs2069825; rs3087225; rs2069861; rs36215814; rs2234683; rs2069828; rs11544633; rs41477054; rs13306438; rs3915892; rs3915893; rs2069839; rs13306434; rs3087234; rs2069846; rs2069836; rs3087235; rs2069859; rs13447445; rs36215459; rs36215820; rs35081782; rs35178191; rs13447446; rs2069826; rs34328912; rs3087224; rs36215821; rs4335044; rs36215822; rs11973115; rs36215817; rs11445458; rs34224237; rs36215461; rs36215818; rs34280821; rs34012176; rs34709428; rs10242595; rs10499563; rs11766273; rs12700386; rs12700390; rs13438415; rs1546762; rs1546763; rs17147230; rs1880241; rs1880242; rs1880243; rs2069852; rs2069853; rs2069854; rs2069855; rs2069862; rs3087221; rs3087238; rs35610689; rs4398801; rs4719713; rs4719714; rs6461662; rs6946908; rs6963444; rs6963591; rs7458109; rs7784987; rs7801617; rs7805828; rs940367

# Macromolecular_Interacting_Partner_11_General_References:
3491322; 3500852; 3538015; 3023045; 3320204; 2789513; 3758081; 3266463; 1291290; 3279116; 2610854; 1883960; 7851440; 2472117; 2037043; 8555185; 9159484; 9118960

# Macromolecular_Interacting_Partner_11_References:
17062603

# Macromolecular_Interacting_Partner_12_ID:
6945

# Macromolecular_Interacting_Partner_12_Name:
Cholesteryl ester transfer protein precursor

# Macromolecular_Interacting_Partner_12_Synonyms:
Lipid transfer protein I

# Macromolecular_Interacting_Partner_12_Gene_Name:
CETP

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Cholesteryl ester transfer protein precursor
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
493

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
54757

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
6.02

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  binding
Function:  lipid binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF01273:LBP_BPI_CETP;
PF02886:LBP_BPI_CETP_C

# Macromolecular_Interacting_Partner_12_Signals:
1-17

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
180260

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
CETP_HUMAN (P11597)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
CETP

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
CETP

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:1869

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Secreted protein; extracellular space

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>1482 bp
ATGCTGGCTGCCACAGTCCTGACCCTGGCCCTGCTGGGCAATGCCCATGCCTGCTCCAAA
GGCACCTCGCACGAGGCAGGCATCGTGTGCCGCATCACCAAGCCTGCCCTCCTGGTGTTG
AACCACGAGACTGCCAAGGTGATCCAGACCGCCTTCCAGCGAGCCAGCTACCCAGATATC
ACGGGCGAGAAGGCCATGATGCTCCTTGGCCAAGTCAAGTATGGGTTGCACAACATCCAG
ATCAGCCACTTGTCCATCGCCAGCAGCCAGGTGGAGCTGGTGGAAGCCAAGTCCATTGAT
GTCTCCATTCAGAACGTGTCTGTGGTCTTCAAGGGGACCCTGAAGTATGGCTACACCACT
GCCTGGTGGCTGGGTATTGATCAGTCCATTGACTTCGAGATCGACTCTGCCATTGACCTC
CAGATCAACACACAGCTGACCTGTGACTCTGGTAGAGTGCGGACCGATGCCCCTGACTGC
TACCTGTCTTTCCATAAGCTGCTCCTGCATCTCCAAGGGGAGCGAGAGCCTGGGTGGATC
AAGCAGCTGTTCACAAATTTCATCTCCTTCACCCTGAAGCTGGTCCTGAAGGGACAGATC
TGCAAAGAGATCAACGTCATCTCTAACATCATGGCCGATTTTGTCCAGACAAGGGCTGCC
AGCATCCTTTCAGATGGAGACATTGGGGTGGACATTTCCCTGACAGGTGATCCCGTCATC
ACAGCCTCCTACCTGGAGTCCCATCACAAGGGTCATTTCATCTACAAGAATGTCTCAGAG
GACCTCCCCCTCCCCACCTTCTCGCCCACACTGCTGGGGGACTCCCGCATGCTGTACTTC
TGGTTCTCTGAGCGAGTCTTCCACTCGCTGGCCAAGGTAGCTTTCCAGGATGGCCGCCTC
ATGCTCAGCCTGATGGGAGACGAGTTCAAGGCAGTGCTGGAGACCTGGGGCTTCAACACC
AACCAGGAAATCTTCCAAGAGGTTGTCGGCGGCTTCCCCAGCCAGGCCCAAGTCACCGTC
CACTGCCTCAAGATGCCCAAGATCTCCTGCCAAAACAAGGGAGTCGTGGTCAATTCTTCA
GTGATGGTGAAATTCCTCTTTCCACGCCCAGACCAGCAACATTCTGTAGCTTACACATTT
GAAGAGGATATCGTGACTACCGTCCAGGCCTCCTATTCTAAGAAAAAGCTCTTCTTAAGC
CTCTTGGATTTCCAGATTACACCAAAGACTGTTTCCAACTTGACTGAGAGCAGCTCCGAG
TCCATCCAGAGCTTCCTGCAGTCAATGATCACCGCTGTGGGCATCCCTGAGGTCATGTCT
CGGCTCGAGGTAGTGTTTACAGCCCTCATGAACAGCAAAGGCGTGAGCCTCTTCGACATC
ATCAACCCTGAGATTATCACTCGAGATGGCTTCCTGCTGCTGCAGATGGACTTTGGCTTC
CCTGAGCACCTGCTGGTGGATTTCCTCCAGAGCTTGAGCTAG

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
M30185

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_12_Locus:
16q21

# Macromolecular_Interacting_Partner_12_SNPs:
rs5880; rs5882; rs2303790; rs5887; rs34065661; rs1800777; rs2228667; rs34716057; rs5881; rs34855278; rs5884; rs5886; rs5883; rs5885; rs7192120; rs1801706; rs17231520; rs289716; rs7195984; rs11076174; rs820299; rs158477; rs289741; rs11076177; rs1800774; rs7205804; rs11076176; rs4369653; rs289715; rs1532625; rs12720925; rs12691052; rs12598103; rs12720861; rs4784744; rs2033254; rs9930761; rs12720933; rs891144; rs12708973; rs1968905; rs12720872; rs891141; rs12720884; rs289719; rs12708979; rs9939224; rs158479; rs289717; rs291043; rs3816117; rs12447620; rs7194225; rs1532624; rs12597250; rs7196174; rs12720862; rs708272; rs708273; rs4784745; rs289714; rs12708974; rs7203984; rs4587963; rs12720939; rs12708976; rs711752; rs9926440; rs289740; rs291044; rs8045701; rs8053613; rs12720942; rs158478; rs7499892; rs12708980; rs12708971; rs17239354; rs12708985; rs12720863; rs12720890; rs12720897; rs12708983; rs12720922; rs12720901; rs17231590; rs289713; rs12720903; rs2303789; rs9923854; rs12720896; rs12708981; rs4784741; rs12720866; rs12720931; rs9924087; rs9929488; rs12720941; rs11644475; rs12720857; rs891143; rs1864163; rs12720898; rs11508026; rs12720908; rs4784742; rs12720858; rs2304475; rs12720873; rs12720906; rs158480; rs891142; rs12720894; rs12720864; rs7197854; rs9936680; rs12720860; rs12720871; rs9935228; rs17231534; rs11076175; rs12720889; rs12708984; rs12720887; rs158617; rs12720877; rs736274; rs12708982; rs289718; rs12720937; rs12720926; rs12596364; rs12720905; rs12720899; rs12720900; rs12597002; rs12720892; rs5817082; rs12720913; rs12708969; rs17237946; rs17231569; rs34602471; rs17231869; rs3794643; rs13306229; rs34680782; rs34426213; rs34847858; rs8045855; rs17237953; rs12597025; rs35928970; rs13306232; rs35619327; rs34337891; rs36051594; rs11860407; rs35172227; rs12444012; rs12599791; rs12447839; rs4783961; rs289742; rs12447924; rs289744; rs12720918; rs12708968; rs17237883; rs17231506; rs1800775; rs711751; rs13332526; rs13332571; rs13338602; rs1800776; rs289743; rs821840; rs4783962; rs17245715; rs36122917; rs34119551; rs34611098; rs28381707; rs28381708; rs35878799; rs5742907; rs34904808; rs34498052; rs1864165; rs35874588; rs35239382; rs3891197; rs35752722; rs12149409; rs13331688; rs17237939; rs28381709; rs35715238; rs34620476; rs11641075; rs13306230; rs17237911; rs35926917; rs5817083; rs1078367; rs5030708; rs4784739; rs35088638; rs34279747; rs17237967; rs17231834; rs3891195; rs35404403; rs34145065; rs4784743; rs17238225; rs34355970; rs17238232; rs7405284; rs34427043; rs3891194; rs11347120; rs34817019; rs35412907; rs5742908; rs35915925; rs17231583; rs35585922; rs35656795; rs7197340; rs7198026; rs11276066; rs34637366; rs35623598; rs34710773; rs3891196; rs13306231; rs35373375; rs34523084; rs11333160; rs35895516; rs4784746; rs289739; rs34207398; rs34821132; rs35984702; rs1864164; rs34267814; rs35931780; rs4784740; rs36229787; rs34192661; rs1799851; rs35634210; rs36229487; rs36229491; rs33933811; rs34175087; rs36229786; rs35702827; rs36229485; rs36229484; rs36229492; rs821841; rs28419404; rs35549891; rs35222164; rs34600620; rs12446515; rs12599484; rs12599565; rs12708967; rs12708970; rs12720916; rs12720917; rs12920974; rs12934552; rs1566439; rs172337; rs17290922; rs173539; rs17369163; rs247616; rs289746; rs289747; rs289748; rs289749; rs289750; rs289752; rs3764261; rs4783963; rs6499861; rs6499863; rs7192754; rs7197864; rs7203286; rs7205459; rs7205692

# Macromolecular_Interacting_Partner_12_General_References:
3600759; 2334701; 8943225; 9332354; 8408659; 10391209; 12966036

# Macromolecular_Interacting_Partner_12_References:
16960121; 16973241; 16986521; 17002260

# Macromolecular_Interacting_Partner_13_ID:
7619

# Macromolecular_Interacting_Partner_13_Name:
Platelet glycoprotein 4

# Macromolecular_Interacting_Partner_13_Synonyms:
Platelet glycoprotein IV; GPIV; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; CD36 antigen; PAS IV; PAS-4 protein; Platelet collagen receptor; Fatty acid translocase; FAT; Thrombospondin receptor

# Macromolecular_Interacting_Partner_13_Gene_Name:
CD36

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Platelet glycoprotein 4
MGCDRNCGLIAGAVIGAVLAVFGGILMPVGDLLIQKTIKKQVVLEEGTIAFKNWVKTGTE
VYRQFWIFDVQNPQEVMMNSSNIQVKQRGPYTYRVRFLAKENVTQDAEDNTVSFLQPNGA
IFEPSLSVGTEADNFTVLNLAVAAASHIYQNQFVQMILNSLINKSKSSMFQVRTLRELLW
GYRDPFLSLVPYPVTTTVGLFYPYNNTADGVYKVFNGKDNISKVAIIDTYKGKRNLSYWE
SHCDMINGTDAASFPPFVEKSQVLQFFSSDICRSIYAVFESDVNLKGIPVYRFVLPSKAF
ASPVENPDNYCFCTEKIISKNCTSYGVLDISKCKEGRPVYISLPHFLYASPDVSEPIDGL
NPNEEEHRTYLDIEPITGFTLQFAKRLQVNLLVKPSEKIQVLKNLKRNYIVPILWLNETG
TIGDEKANMFRSQVTGKINLLGLIEMILLSVGVVMFVAFMISYCACRSKTIK

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
472

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
53054

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
8.06

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular process
Process:  cell adhesion
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF01130:CD36

# Macromolecular_Interacting_Partner_13_Signals:
1-23

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
178671

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
CD36_HUMAN (P16671)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
CD36

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
CD36

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:1663

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>1419 bp
ATGGGCTGTGACCGGAACTGTGGGCTCATCGCTGGGGCTGTCATTGGTGCTGTCCTGGCT
GTGTTTGGAGGTATTCTAATGCCAGTTGGAGACCTGCTTATCCAGAAGACAATTAAAAAG
CAAGTTGTCCTCGAAGAAGGTACAATTGCTTTTAAAAATTGGGTTAAAACAGGCACAGAA
GTTTACAGACAGTTTTGGATCTTTGATGTGCAAAATCCACAGGAAGTGATGATGAACAGC
AGCAACATTCAAGTTAAGCAAAGAGGTCCTTATACGTACAGAGTTCGTTTTCTAGCCAAG
GAAAATGTAACCCAGGACGCTGAGGACAACACAGTCTCTTTCCTGCAGCCCAATGGTGCC
ATCTTCGAACCTTCACTATCAGTTGGAACAGAGGCTGACAACTTCACAGTTCTCAATCTG
GCTGTGGCAGCTGCATCCCATATCTATCAAAATCAATTTGTTCAAATGATCCTCAATTCA
CTTATTAACAAGTCAAAATCTTCTATGTTCCAAGTCAGAACTTTGAGAGAACTGTTATGG
GGCTATAGGGATCCATTTTTGAGTTTGGTTCCGTACCCTGTTACTACCACAGTTGGTCTG
TTTTATCCTTACAACAATACTGCAGATGGAGTTTATAAAGTTTTCAATGGAAAAGATAAC
ATAAGTAAAGTTGCCATAATCGACACATATAAAGGTAAAAGGAATCTGTCCTATTGGGAA
AGTCACTGCGACATGATTAATGGTACAGATGCAGCCTCATTTCCACCTTTTGTTGAGAAA
AGCCAGGTATTGCAGTTCTTTTCTTCTGATATTTGCAGGTCAATCTATGCTGTATTTGAA
TCCGACGTTAATCTGAAAGGAATCCCTGTGTATAGATTTGTTCTTCCATCCAAGGCCTTT
GCCTCTCCAGTTGAAAACCCAGACAACTATTGTTTCTGCACAGAAAAAATTATCTCAAAA
AATTGTACATCATATGGTGTGCTAGACATCAGCAAATGCAAAGAAGGGAGACCTGTGTAC
ATTTCACTTCCTCATTTTCTGTATGCAAGTCCTGATGTTTCAGAACCTATTGATGGATTA
AACCCAAATGAAGAAGAACATAGGACATACTTGGATATTGAACCTATAACTGGATTCACT
TTACAATTTGCAAAACGGCTGCAGGTCAACCTATTGGTCAAGCCATCAGAAAAAATTCAA
GTATTAAAGAATCTGAAGAGGAACTATATTGTGCCTATTCTTTGGCTTAATGAGACTGGG
ACCATTGGTGATGAGAAGGCAAACATGTTCAGAAGTCAAGTAACTGGAAAAATAAACCTC
CTTGGCCTGATAGAAATGATCTTACTCAGTGTTGGTGTGGTGATGTTTGTTGCTTTTATG
ATTTCATATTGTGCATGCAGATCGAAAACAATAAAATAA

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
M24795

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_13_Locus:
7q11.2

# Macromolecular_Interacting_Partner_13_SNPs:
rs3211938; rs1803256; rs5957; rs5956; rs3211907; rs1194181; rs3212161; rs1949818; rs7755; rs1722505; rs1761661; rs1464792; rs1194179; rs1413661; rs1194178; rs2691199; rs3212160; rs6973242; rs2151916; rs3211958; rs1537593; rs1537477; rs1722506; rs3211959; rs1761665; rs6968407; rs1205467; rs12532196; rs3212162; rs1049654; rs6960369; rs3212164; rs1761667; rs1194180; rs4545029; rs1761663; rs3212163; rs1722507; rs10268404; rs4728183; rs11971740; rs6972923; rs1722502; rs10268417; rs9918586; rs12531218; rs10268765; rs10499858; rs3212018; rs1537591; rs10499859; rs10215288; rs3211956; rs1880410; rs12534733; rs12536106; rs1360741; rs17263407; rs1572230; rs12531609; rs1984112; rs10268662; rs3212159; rs1334513; rs1527479; rs10216184; rs2691200; rs17154155; rs12533372; rs1194177; rs13236689; rs4410854; rs10238304; rs4731642; rs2366855; rs1413657; rs1334511; rs3044712; rs10267891; rs1534314; rs12540395; rs11574729; rs11983805; rs9784998; rs1761664; rs10429164; rs1334516; rs3211805; rs4731643; rs10225432; rs6961024; rs1334512; rs13228738; rs12706912; rs11972894; rs10499860; rs13225492; rs1413656; rs1722509; rs12234728; rs13438282; rs11971793; rs1953298; rs10480808; rs6969989; rs12540402; rs11770907; rs1722504; rs7812074; rs8956; rs12706918; rs2781844; rs17154170; rs17154181; rs12667404; rs11770358; rs1722503; rs1413659; rs10265780; rs10265215; rs1761662; rs3211960; rs4728191; rs11771152; rs10247260; rs13222488; rs9641866; rs11574728; rs12532729; rs1953299; rs4731646; rs17154186; rs3211849; rs3211928; rs3211931; rs3211821; rs3173804; rs3211822; rs997906; rs3211920; rs3211944; rs1924; rs3211867; rs3211834; rs3211940; rs3173799; rs3211886; rs3211883; rs3211909; rs1358337; rs3211845; rs3211816; rs3212165; rs3211885; rs3211820; rs3211828; rs3211942; rs3211839; rs3173798; rs3211827; rs1054516; rs3211851; rs3211887; rs3807075; rs1880955; rs6953487; rs11574716; rs10499861; rs3211954; rs3211850; rs3211908; rs1527483; rs3211869; rs3807076; rs3211846; rs3807090; rs3211911; rs3211842; rs7810964; rs3211905; rs3211864; rs3173802; rs3211838; rs3211932; rs3807073; rs3173805; rs3211830; rs3807077; rs3211913; rs1405747; rs3211844; rs3211817; rs3817556; rs3211917; rs3211831; rs3211810; rs3211881; rs3173800; rs3211818; rs3211812; rs3211843; rs3211912; rs3211868; rs3800553; rs3211916; rs10499862; rs3211949; rs3211915; rs3211825; rs3211904; rs17154239; rs3173803; rs3212001; rs3211895; rs3211863; rs17154233; rs9282633; rs3212004; rs17154209; rs3211999; rs3211813; rs3211910; rs3211947; rs3211866; rs1880956; rs3211819; rs3211874; rs3211933; rs17154258; rs3211870; rs3211903; rs3211854; rs3211858; rs3211896; rs3211897; rs3211852; rs3212012; rs3212008; rs9282636; rs3212005; rs3212170; rs3211952; rs11574715; rs3211919; rs3211890; rs3212011; rs3211925; rs3211848; rs3211945; rs3211872; rs3211809; rs9282634; rs17154246; rs3173801; rs3211902; rs3211841; rs3211891; rs3211808; rs3211873; rs4986864; rs3211857; rs3211824; rs17154232; rs3211815; rs3211876; rs3211884; rs3211811; rs1527484; rs17154225; rs3211929; rs3211914; rs9282635; rs3212003; rs4986863; rs3211878; rs3211856; rs3211865; rs3211918; rs3211946; rs1054517; rs9282637; rs3211892; rs1527463; rs3211899; rs3211935; rs3211926; rs3211939; rs3211906; rs3211888; rs3211823; rs3211859; rs3211889; rs3211927; rs3211879; rs3212009; rs3211875; rs3212000; rs17154213; rs3211880; rs3211826; rs3211814; rs3211934; rs17265158; rs3211871; rs3211930; rs3823475; rs3211806; rs3211941; rs3211855; rs1133344; rs11574709; rs3211923; rs3211882; rs3211836; rs3212013; rs1194182; rs1049673; rs13246513; rs17154137; rs17154133; rs35398731; rs2272350; rs4645507; rs35793888; rs3211861; rs13306227; rs35776095; rs41478146; rs1130696; rs3211901; rs3211893; rs12055955; rs34129321; rs33926837; rs3044666; rs10428893; rs11450631; rs34416933; rs1969494; rs12530754; rs11301209; rs35342482; rs28645928; rs34620540; rs11402083; rs35216295; rs41272369; rs13306226; rs5885184; rs7782100; rs35880722; rs35726535; rs10252678; rs35503056; rs1537592; rs36088538; rs11321468; rs1722501; rs35179913; rs9918530; rs34516458; rs12530623; rs1722508; rs13310587; rs13311181; rs34388229; rs5885188; rs1722510; rs35775198; rs34462103; rs34229217; rs13311175; rs10633454; rs6150187; rs7784648; rs10235039; rs35355478; rs36122853; rs1953300; rs35176633; rs35638681; rs4626520; rs1334517; rs3040906; rs13311184; rs11489664; rs13312376; rs13310579; rs17154147; rs3044686; rs3211957; rs34638645; rs7811490; rs34555144; rs13311245; rs13306228; rs34217287; rs5885187; rs34710564; rs34345674; rs34761395; rs34829889; rs34745595; rs2691198; rs4316098; rs36055469; rs35289985; rs34028827; rs11294590; rs7808408; rs35802187; rs34781678; rs36013152; rs1722511; rs34801616; rs7778263; rs34506573; rs35574453; rs5885186; rs33940674; rs34493313; rs10643354; rs35574179; rs12706916; rs13244883; rs1413660; rs35468175; rs1334514; rs2366856; rs28694631; rs5885185; rs13312487; rs13233631; rs10228291; rs34289333; rs13244869; rs1334515; rs11318589; rs35634523; rs10265457; rs41272372; rs3044710; rs3211924; rs4986862; rs1133345; rs11574718; rs28428736; rs3212017; rs11437085; rs35439945; rs11574721; rs3211953; rs3847100; rs3212014; rs3212007; rs3736592; rs28441220; rs34304108; rs3211829; rs28462358; rs3212002; rs11464530; rs3212166; rs35268194; rs7457162; rs3212169; rs10249908; rs35368854; rs3211900; rs3212015; rs3211833; rs35200450; rs11450578; rs41281225; rs41364549; rs1054518; rs34461332; rs3211951; rs3211853; rs11574711; rs10263695; rs3212006; rs3212168; rs3915268; rs3211936; rs10263961; rs10669209; rs3211840; rs3211937; rs13221438; rs3211922; rs3211835; rs10270675; rs3807074; rs3211921; rs28659874; rs3807085; rs3211837; rs3832458; rs11574703; rs41274179; rs10249784; rs3044693; rs3211950; rs5885189; rs3211847; rs34141101; rs10718681; rs3211898; rs34761121; rs34614420; rs35463927; rs10536999; rs2065667; rs34744646; rs2065666; rs35106817; rs3211862; rs10245610; rs10262906; rs10263763; rs10499856; rs10499857; rs11771839; rs11772036; rs12666644; rs12706949; rs13223096; rs13226840; rs13230419; rs1334518; rs1524596; rs1524597; rs17154125; rs17154304; rs17154309; rs17154312; rs17154316; rs17154320; rs1722516; rs17266080; rs3807072; rs5012406; rs7789369; rs7807607; rs819435; rs819436; rs819437; rs819439

# Macromolecular_Interacting_Partner_13_General_References:
2473841; 7693552; 7505064; 7518447; 2468669; 11668637; 7503937; 8798390; 7533783; 10391209; 10890433; 11950861; 12506336

# Macromolecular_Interacting_Partner_13_References:
16938301; 16959872; 17110163

# Macromolecular_Interacting_Partner_14_ID:
5992

# Macromolecular_Interacting_Partner_14_Name:
Corticosteroid 11-beta-dehydrogenase isozyme 1

# Macromolecular_Interacting_Partner_14_Synonyms:
11-DH; 11-beta-hydroxysteroid dehydrogenase 1; 11-beta-HSD1

# Macromolecular_Interacting_Partner_14_Gene_Name:
HSD11B1

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>Corticosteroid 11betadehydrogenase isozyme 1
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKET
LQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILN
HITNTSLNLFHDDIHHVRKSM
EVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYP
MVAAYSASKFALDGFFSSIRKEYSVSRVNVSI
TLCVLGLIDTETAMKAVSGIVHMQAAP
KEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLY
STSYNMDRFINK

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
292

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
32401

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
8.77

# Macromolecular_Interacting_Partner_14_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_14_General_Function:
Lipid transport and metabolism 

# Macromolecular_Interacting_Partner_14_Specific_Function:
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol

# Macromolecular_Interacting_Partner_14_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Macromolecular_Interacting_Partner_14_Reaction:
an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF00106:adh_short

# Macromolecular_Interacting_Partner_14_Signals:
1-23

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
EC 1.1.1.146

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
179475

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
DHI1_HUMAN (P28845)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
HSD11B1

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
HSD11B1

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:5208

# Macromolecular_Interacting_Partner_14_PDB_ID:
1XU9

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>879 bp

ATGGCTTTTATGAAAAAATATCTCCTCCCCATTCTGGGGCTCTTCATGGCCTACTACTA
CTATTCTGCAA
ACGAGGAATTCAGACCAGAGATGCTCCAAGGAAAGAAAGTGATTGTCA
CAGGGGCCAGCAAAGGGATCGG
AAGAGAGATGGCTTATCATCTGGCGAAGATGGGAGCC
CATGTGGTGGTGACAGCGAGGTCAAAAGAAACT
CTACAGAAGGTGGTATCCCACTGCCT
GGAGCTTGGAGCAGCCTCAGCACACTACATTGCTGGCACCATGG
AAGACATGACCTTCG
CAGAGCAATTTGTTGCCCAAGCAGGAAAGCTCATGGGAGGACTAGACATGCTCAT
TCTC
AACCACATCACCAACACTTCTTTGAATCTTTTTCATGATGATATTCACCATGTGCGCAAA
AGCATG
GAAGTCAACTTCCTCAGTTACGTGGTCCTGACTGTAGCTGCCTTGCCCATGCT
GAAGCAGAGCAATGGAA
GCATTGTTGTCGTCTCCTCTCTGGCTGGGAAAGTGGCTTATC
CAATGGTTGCTGCCTATTCTGCAAGCAA
GTTTGCTTTGGATGGGTTCTTCTCCTCCATC
AGAAAGGAATATTCAGTGTCCAGGGTCAATGTATCAATC
ACTCTCTGTGTTCTTGGCCT
CATAGACACAGAAACAGCCATGAAGGCAGTTTCTGGGATAGTCCATATGC
AAGCAGCTC
CAAAGGAGGAATGTGCCCTGGAGATCATCAAAGGGGGAGCTCTGCGCCAAGAAGAAGTGT
A
TTATGACAGCTCACTCTGGACCACTCTTCTGATCAGAAATCCATGCAGGAAGATCCTG
GAATTTCTCTAC
TCAACGAGCTATAATATGGACAGATTCATAAACAAGTAG

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
M76665

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_14_Locus:
1q32-q41

# Macromolecular_Interacting_Partner_14_SNPs:
rs2235543; rs846911; rs846909; rs6752; rs4844880; rs861762; rs11808911; rs760952; rs11804533; rs10863782; rs3753519; rs4844881; rs846910; rs10082169; rs860185; rs846914; rs11590066; rs760951; rs2357075; rs10082248; rs11805981; rs6656906; rs11119326; rs12565406; rs10863781; rs7543025; rs968033; rs932335; rs1474654; rs2884090; rs2282738; rs846906; rs11119328; rs3766619; rs3766618; rs1474655; rs2236902; rs1000283; rs11808690; rs7539852; rs6679099; rs11811440; rs9430013; rs12040780; rs9430014; rs12086634; rs6672256; rs2298930; rs11119327; rs11807619; rs2282740; rs11806703; rs9430012; rs4314885; rs11799643; rs12116437; rs631923; rs2236904; rs11487867; rs4844890; rs12060922; rs11119333; rs10863783; rs17015069; rs12024779; rs17015053; rs1000282; rs2236903; rs12059226; rs11119332; rs12138452; rs12561766; rs1415542; rs11119330; rs2282739; rs4844488; rs11119331; rs846908; rs701950; rs11119325; rs41283132; rs1047202; rs17850941; rs35932418; rs41283130; rs34506121; rs36212444; rs12039840; rs3059689; rs35096215; rs34785756; rs5780532; rs35689564; rs35479221; rs7529376; rs12041309; rs13306420; rs36212449; rs34533406; rs12138389; rs846915; rs12734051; rs12757955; rs13306419; rs36212447; rs35179819; rs36212448; rs13306421; rs12128216; rs10863780; rs12030418; rs12047442; rs7528902; rs34580232; rs12143228; rs1883442; rs35492868; rs3920499; rs12034329; rs13306422; rs12063265; rs34578769; rs34407603; rs11485195; rs12060420; rs12097899; rs34038823; rs12759302; rs35966136; rs7547027; rs35349406; rs12094117; rs13306423; rs28895393; rs34755409; rs35206856; rs3059693; rs17015042; rs5780533; rs5780534; rs11119329; rs4844889; rs11464749; rs12090931; rs34148285; rs34574844; rs11802270; rs35890324; rs34866038; rs1890085; rs11487866; rs12745309; rs10614817; rs35939947; rs34941680; rs2282741; rs2236905; rs11591045; rs34205549; rs35603025; rs11119334; rs34727634; rs10863785; rs11576775; rs12123431; rs1337529; rs1337532; rs17015076; rs17015078; rs17317033; rs17389016; rs2064148; rs2205985; rs35394268; rs3765240; rs4393158; rs4545339; rs4844891; rs6540547; rs6694238; rs7513155; rs7517562; rs7528642; rs7532021; rs7532324; rs7548781; rs7550346; rs846907; rs9430016

# Macromolecular_Interacting_Partner_14_General_References:
1885595

# Macromolecular_Interacting_Partner_14_References:
16932315; 16933103; 16940190; 16946132

# Macromolecular_Interacting_Partner_15_ID:
7657

# Macromolecular_Interacting_Partner_15_Name:
Peroxisome proliferator-activated receptor gamma

# Macromolecular_Interacting_Partner_15_Synonyms:
PPAR-gamma

# Macromolecular_Interacting_Partner_15_Gene_Name:
PPARG

# Macromolecular_Interacting_Partner_15_Protein_Sequence:
>Peroxisome proliferatoractivated receptor gamma
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY

# Macromolecular_Interacting_Partner_15_Number_of_Residues:
505

# Macromolecular_Interacting_Partner_15_Molecular_Weight:
57621

# Macromolecular_Interacting_Partner_15_Theoretical_pI:
5.77

# Macromolecular_Interacting_Partner_15_GO_Classification:
>>>
Function:  steroid hormone receptor activity
Function:  transcription factor activity
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_15_General_Function:
Not Available

# Macromolecular_Interacting_Partner_15_Specific_Function:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis

# Macromolecular_Interacting_Partner_15_Pathway:
Not Available

# Macromolecular_Interacting_Partner_15_Reaction:
Not Available

# Macromolecular_Interacting_Partner_15_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_15_Signals:
None

# Macromolecular_Interacting_Partner_15_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_15_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_15_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_15_GenBank_ID_Protein:
1711117

# Macromolecular_Interacting_Partner_15_SwissProt_ID:
PPARG_HUMAN (P37231)

# Macromolecular_Interacting_Partner_15_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_15_Genecard_id:
PPARG

# Macromolecular_Interacting_Partner_15_Geneatlas_id:
PPARG

# Macromolecular_Interacting_Partner_15_hgnc_id:
HGNC:9236

# Macromolecular_Interacting_Partner_15_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_15_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_15_Gene_Sequence:
>1518 bp
ATGGGTGAAACTCTGGGAGATTCTCCTATTGACCCAGAAAGCGATTCCTTCACTGATACA
CTGTCTGCAAACATATCACAAGAAATGACCATGGTTGACACAGAGATGCCATTCTGGCCC
ACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCACTCCTTT
GATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGAC
ATTCCATTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATGACCTGAAACTTCAA
GAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAGAAGACT
CAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGT
GTCTGTGGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAG
GGTTTCTTCCGGAGAACAATCAGATTGAAGCTTATCTATGACAGATGTGATCTTAACTGT
CGGATCCACAAAAAAAGTAGAAATAAATGTCAGTACTGTCGGTTTCAGAAATGCCTTGCA
GTGGGGATGTCTCATAATGCCATCAGGTTTGGGCGGATGCCACAGGCCGAGAAGGAGAAG
CTGTTGGCGGAGATCTCCAGTGATATCGACCAGCTGAATCCAGAGTCCGCTGACCTCCGG
GCCCTGGCAAAACATTTGTATGACTCATACATAAAGTCCTTCCCGCTGACCAAAGCAAAG
GCGAGGGCGATCTTGACAGGAAAGACAACAGACAAATCACCATTCGTTATCTATGACATG
AATTCCTTAATGATGGGAGAAGATAAAATCAAGTTCAAACACATCACCCCCCTGCAGGAG
CAGAGCAAAGAGGTGGCCATCCGCATCTTTCAGGGCTGCCAGTTTCGCTCCGTGGAGGCT
GTGCAGGAGATCACAGAGTATGCCAAAAGCATTCCTGGTTTTGTAAATCTTGACTTGAAC
GACCAAGTAACTCTCCTCAAATATGGAGTCCACGAGATCATTTACACAATGCTGGCCTCC
TTGATGAATAAAGATGGGGTTCTCATATCCGAGGGCCAAGGCTTCATGACAAGGGAGTTT
CTAAAGAGCCTGCGAAAGCCTTTTGGTGACTTTATGGAGCCCAAGTTTGAGTTTGCTGTG
AAGTTCAATGCACTGGAATTAGATGACAGCGACTTGGCAATATTTATTGCTGTCATTATT
CTCAGTGGAGACCGCCCAGGTTTGCTGAATGTGAAGCCCATTGAAGACATTCAAGACAAC
CTGCTACAAGCCCTGGAGCTCCAGCTGAAGCTGAACCACCCTGAGTCCTCACAGCTGTTT
GCCAAGCTGCTCCAGAAAATGACAGACCTCAGACAGATTGTCACGGAACACGTGCAGCTA
CTGCAGGTGATCAAGAAGACGGAGACAGACATGAGTCTTCACCCGCTCCTGCAGGAGATC
TACAAGGACTTGTACTAG

# Macromolecular_Interacting_Partner_15_GenBank_ID_Gene:
U79012

# Macromolecular_Interacting_Partner_15_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_15_Locus:
3p25

# Macromolecular_Interacting_Partner_15_SNPs:
rs1801282; rs3856806; rs4135352; rs13306747; rs1805151; rs2921188; rs2881654; rs6776454; rs12496005; rs2197423; rs4135307; rs4135315; rs4135316; rs880663; rs9829551; rs11128598; rs12636454; rs4135304; rs4135255; rs4135322; rs12631389; rs6800910; rs4135311; rs12487012; rs4135321; rs4135305; rs1064323; rs6800748; rs12496505; rs2120825; rs4135301; rs10510412; rs2028759; rs4135323; rs6802898; rs12629240; rs7647481; rs13095716; rs4135313; rs4684101; rs6805419; rs4135302; rs7627605; rs6809631; rs9310401; rs4135245; rs9817428; rs1899951; rs2938397; rs4135259; rs4135308; rs10865710; rs11715073; rs4684848; rs4135320; rs3885307; rs6778740; rs12629293; rs4135246; rs12636461; rs13433696; rs1373641; rs9812662; rs12639162; rs4135306; rs12633551; rs12497191; rs9858822; rs12629751; rs4135253; rs7648033; rs1596667; rs11128597; rs13083375; rs13070963; rs2007629; rs12630210; rs4135254; rs11128601; rs4135258; rs10510410; rs4135310; rs4145574; rs4135317; rs7646510; rs7636145; rs17036342; rs6768587; rs7620165; rs2012444; rs6798974; rs4135256; rs3892175; rs13073869; rs1122648; rs6782178; rs4145573; rs10510411; rs4135319; rs4135318; rs2938398; rs2972167; rs964232; rs4135247; rs2028760; rs17036328; rs10510418; rs9883281; rs11128603; rs4135312; rs6442311; rs12493718; rs9851767; rs2921189; rs11128599; rs17817276; rs6785890; rs13061415; rs2938396; rs4135248; rs4135257; rs4135303; rs6442310; rs12485478; rs7638903; rs7617488; rs28763893; rs4135250; rs17793693; rs12490265; rs17036326; rs7646425; rs4135249; rs2972164; rs1373640; rs17036263; rs4135251; rs4135314; rs12631819; rs11710969; rs7638788; rs17036321; rs11128596; rs4135309; rs12639094; rs17036188; rs6795085; rs12629497; rs3112395; rs6808179; rs2920505; rs12631028; rs6795946; rs13064760; rs6809832; rs35206526; rs7649970; rs17036314; rs11128600; rs4684845; rs10865711; rs12631322; rs7615916; rs9882725; rs9849386; rs2067819; rs11716748; rs17817469; rs17029006; rs4684846; rs2881479; rs17036242; rs6788489; rs11719186; rs6792284; rs4073770; rs12634544; rs2972168; rs2921190; rs9842021; rs13306745; rs11715016; rs11128602; rs13076055; rs12496413; rs7610055; rs9823137; rs9883193; rs17435731; rs2346795; rs4362702; rs10510417; rs6768049; rs12330440; rs12495364; rs9814788; rs17029008; rs2067820; rs6766920; rs11709077; rs2960422; rs17425935; rs17036163; rs17036281; rs17036160; rs6801982; rs4518111; rs17050719; rs3112393; rs4684847; rs17036174; rs17036282; rs10212597; rs34359034; rs17036165; rs35080475; rs17036333; rs17793951; rs1984669; rs17036170; rs12486170; rs9876942; rs12635309; rs4315668; rs11718775; rs9870196; rs3963364; rs1373642; rs1822825; rs2959273; rs2938394; rs2938392; rs1151998; rs709149; rs796313; rs709156; rs1175543; rs1175540; rs2959272; rs2972162; rs1875796; rs1151996; rs1151997; rs1797912; rs709154; rs796290; rs4135359; rs4135343; rs4135260; rs4135354; rs1152002; rs4135293; rs709157; rs4135327; rs709148; rs4135358; rs709152; rs4135329; rs4135344; rs2938395; rs4135263; rs4135330; rs1177809; rs4135345; rs4135296; rs4135264; rs1151999; rs2655259; rs4135324; rs4135332; rs4135276; rs709147; rs4135356; rs709151; rs4135362; rs6442313; rs709158; rs4135282; rs4135333; rs6442312; rs4135281; rs1175541; rs1175542; rs4135340; rs4135277; rs4135350; rs2938387; rs4135266; rs4135288; rs7626560; rs4135341; rs2921193; rs4135285; rs4135361; rs4135348; rs4135326; rs2938389; rs4135347; rs4135351; rs4135261; rs2972163; rs4135337; rs4135292; rs4135286; rs709155; rs2938388; rs10510420; rs4135299; rs4135283; rs2959271; rs4135273; rs4135294; rs7645903; rs4135284; rs4135335; rs4135280; rs709150; rs4135274; rs4135357; rs4135289; rs6794024; rs709153; rs4135331; rs1152001; rs7650895; rs4135336; rs1699337; rs2959269; rs4135346; rs4135265; rs4135275; rs4135278; rs4135297; rs6782475; rs4135295; rs4135355; rs10510419; rs4135334; rs4135338; rs4135290; rs2959268; rs4135360; rs4135298; rs2292101; rs4135349; rs4135287; rs895095; rs4135267; rs4135339; rs7634282; rs4135353; rs12489347; rs17036700; rs4135262; rs1175544; rs4135291; rs4135270; rs4135268; rs4135342; rs4135328; rs4135279; rs4135325; rs4135269; rs35724001; rs7639159; rs7636854; rs3105363; rs13099828; rs13099634; rs34611445; rs7636421; rs7636598; rs7616804; rs11293844; rs7639005; rs13099078; rs35125975; rs11128604; rs2307991; rs35812816; rs9282832; rs36073622; rs7623946; rs9871668; rs12632365; rs4684103; rs35995141; rs7635807; rs6784211; rs9836965; rs35520264; rs9876829; rs4135364; rs13077495; rs13076933; rs17029002; rs4135363; rs4135300; rs17425960; rs34577159; rs9880344; rs17028996; rs35138542; rs9714363; rs35204164; rs2920502; rs28936407; rs1805192; rs1800571; rs41516544; rs28763894; rs13306746; rs41415646; rs34462475; rs34797620; rs13085211; rs35324344; rs28675782; rs34047730; rs9812856; rs34861493; rs11558404; rs34251960; rs35459073; rs2972165; rs13316783; rs34091265; rs34108955; rs2347528; rs6802327; rs35658489; rs34391565; rs34034515; rs11718894; rs34727071; rs33992296; rs2921186; rs13067060; rs2197424; rs3031383; rs28469357; rs9812859; rs35649998; rs35590426; rs13090995; rs17036428; rs17029009; rs34665399; rs34694812; rs11323214; rs5846770; rs13088728; rs35004171; rs17036277; rs9860894; rs11712531; rs34096560; rs13097936; rs13082177; rs35917766; rs36001830; rs28684849; rs17425942; rs34598704; rs17036279; rs3910864; rs34915207; rs11319327; rs35408322; rs28435743; rs2972160; rs11921075; rs13095372; rs3112394; rs4438634; rs36035284; rs11450436; rs2921187; rs34758352; rs13091468; rs10620909; rs11360916; rs10665975; rs7614873; rs17029007; rs9858703; rs11321700; rs34832349; rs35958630; rs36009235; rs11712037; rs35256588; rs35816057; rs17050720; rs10212146; rs35562755; rs10212145; rs34295844; rs7650213; rs3112392; rs35763971; rs11719187; rs35248164; rs34914033; rs7627000; rs2972161; rs9282833; rs7430836; rs11718489; rs17036183; rs13082084; rs35305483; rs35986947; rs35944176; rs2972159; rs5846769; rs17036317; rs9813120; rs11293858; rs35196430; rs9824047; rs11458097; rs11394520; rs34762200; rs2920501; rs35224214; rs34258522; rs35431607; rs35830690; rs1064061; rs7641290; rs5846771; rs35240997; rs35824198; rs1984668; rs3963365; rs11712510; rs34850546; rs28783437; rs28683092; rs34001022; rs2920504; rs10619114; rs35788455; rs17036179; rs9827378; rs35586299; rs35112713; rs11456875; rs35000407; rs6787534; rs12106668; rs13091131; rs34856298; rs34132377; rs13095882; rs6795126; rs2938393; rs35403303; rs11373145; rs36052770; rs13316883; rs10587216; rs3773360; rs7612778; rs11451254; rs35474352; rs4371498; rs11324808; rs35789821; rs9837762; rs11372505; rs13071893; rs2921192; rs35942115; rs11287877; rs1152000; rs11280439; rs11337165; rs35434486; rs1797879; rs11346922; rs35190152; rs41311317; rs10540594; rs35649722; rs10049123; rs34692304; rs1699373; rs10602525; rs34493672; rs34334895; rs3821614; rs9837916; rs1797878; rs12629147; rs9843706; rs13064303; rs35491663; rs35258697; rs10643169; rs4684852; rs2938391; rs35632413; rs35218291; rs3127609; rs5846772; rs3105364; rs13095707; rs34897095; rs2938390; rs35121790; rs6147711; rs13075164; rs4684851; rs34151900; rs35880011; rs9833647; rs10614129; rs1987536; rs11427297; rs35082382; rs36025945; rs13095719; rs36121170; rs3836371; rs34898812; rs34318338; rs11914306; rs3127608; rs35948804; rs11344254; rs796289; rs11377897; rs35598149; rs10575755; rs36055981; rs11368226; rs11713869; rs10048953; rs11446342; rs1797895; rs35691895; rs41484149; rs1185785; rs11329101; rs3773357; rs3210577; rs41293379; rs28848197; rs34241217; rs7627540; rs3103310; rs4684102; rs35168570; rs41491647; rs10222537; rs1152003; rs1152004; rs1152005; rs1175545; rs1181795; rs13066537; rs13090265; rs1663813; rs17036753; rs1797877; rs2920500; rs2920503; rs2960421; rs4498025; rs4684104; rs6790976; rs709159; rs7609637; rs7616847; rs7622847; rs7643499; rs9827787; rs9831245; rs9831411; rs9833097; rs9837686; rs9868474

# Macromolecular_Interacting_Partner_15_General_References:
9065481; 8702406; 9144532; 7787419; 9356045; 8706692; 10681503; 11971969; 10882139; 9425261; 9753710; 10407229; 10394368; 10622252; 11788685

# Macromolecular_Interacting_Partner_15_References:
16959872; 16981222

# Macromolecular_Interacting_Partner_16_ID:
7694

# Macromolecular_Interacting_Partner_16_Name:
Peroxisome proliferator-activated receptor alpha

# Macromolecular_Interacting_Partner_16_Synonyms:
PPAR-alpha

# Macromolecular_Interacting_Partner_16_Gene_Name:
PPARA

# Macromolecular_Interacting_Partner_16_Protein_Sequence:
>Peroxisome proliferatoractivated receptor alpha
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY

# Macromolecular_Interacting_Partner_16_Number_of_Residues:
468

# Macromolecular_Interacting_Partner_16_Molecular_Weight:
52226

# Macromolecular_Interacting_Partner_16_Theoretical_pI:
6.20

# Macromolecular_Interacting_Partner_16_GO_Classification:
>>>
Function:  steroid hormone receptor activity
Function:  transcription factor activity
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_16_General_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Specific_Function:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids

# Macromolecular_Interacting_Partner_16_Pathway:
Not Available

# Macromolecular_Interacting_Partner_16_Reaction:
Not Available

# Macromolecular_Interacting_Partner_16_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_16_Signals:
None

# Macromolecular_Interacting_Partner_16_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_16_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_16_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_16_GenBank_ID_Protein:
307341

# Macromolecular_Interacting_Partner_16_SwissProt_ID:
PPARA_HUMAN (Q07869)

# Macromolecular_Interacting_Partner_16_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_16_Genecard_id:
PPARA

# Macromolecular_Interacting_Partner_16_Geneatlas_id:
PPARA

# Macromolecular_Interacting_Partner_16_hgnc_id:
HGNC:9232

# Macromolecular_Interacting_Partner_16_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_16_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_16_Gene_Sequence:
>1407 bp
ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAG
AGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGGAAACATCCAAGAGATTTCGCAATCC
ATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT
CCTGGCTCAGATGGCTCGGTCATCACGGACACGCTTTCACCAGCTTCGAGCCCCTCCTCG
GTGACTTATCCTGTGGTCCCCGGCAGCGTGGACGAGTCTCCCAGTGGAGCATTGAACATC
GAATGTAGAATCTGCGGGGACAAGGCCTCAGGCTATCATTACGGAGTCCACGCGTGTGAA
GGCTGCAAGGGCTTCTTTCGGCGAACGATTCGACTCAAGCTGGTGTATGACAAGTGCGAC
CGCAGCTGCAAGATCCAGAAAAAGAACAGAAACAAATGCCAGTATTGTCGATTTCACAAG
TGCCTTTCTGTCGGGATGTCACACAACGCGATTCGTTTTGGACGAATGCCAAGATCTGAG
AAAGCAAAACTGAAAGCAGAAATTCTTACCTGTGAACATGACATAGAAGATTCTGAAACT
GCAGATCTCAAATCTCTGGCCAAGAGAATCTACGAGGCCTACTTGAAGAACTTCAACATG
AACAAGGTCAAAGCCCGGGTCATCCTCTCAGGAAAGGCCAGTAACAATCCACCTTTTGTC
ATACATGATATGGAGACACTGTGTATGGCTGAGAAGACGCTGGTGGCCAAGCTGGTGGCC
AATGGCATCCAGAACAAGGAGGTGGAGGTCCGCATCTTTCACTGCTGCCAGTGCACGTCA
GTGGAGACCGTCACGGAGCTCACGGAATTCGCCAAGGCCATCCCAGCGTTCGCAAACTTG
GACCTGAACGATCAAGTGACATTGCTAAAATACGGAGTTTATGAGGCCATATTCGCCATG
CTGTCTTCTGTGATGAACAAAGACGGGATGCTGGTAGCGTATGGAAATGGGTTTATAACT
CGTGAATTCCTAAAAAGCCTAAGGAAACCGTTCTGTGATATCATGGAACCCAAGTTTGAT
TTTGCCATGAAGTTCAATGCACTGGAACTGGATGACAGTGATATCTCCCTTTTTGTGGCT
GCTATCATTTGCTGTGGAGATCGTCCTGGCCTTCTAAACGTAGGACACATTGAAAAAATG
CAGGAGGGTATTGTACATGTGCTCAGACTCCACCTGCAGAGCAACCACCCGGACGATATC
TTTCTCTTCCCAAAACTTCTTCAAAAAATGGCAGACCTCCGGCAGCTGGTGACGGAGCAT
GCGCAGCTGGTGCAGATCATCAAGAAGACGGAGTCGGATGCTGCGCTGCACCCGCTACTG
CAGGAGATCTACAGGGACATGTACTGA

# Macromolecular_Interacting_Partner_16_GenBank_ID_Gene:
L02932

# Macromolecular_Interacting_Partner_16_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_16_Locus:
22q12-q13.1|22q13.31

# Macromolecular_Interacting_Partner_16_SNPs:
rs1800206; rs1800234; rs1800204; rs1800235; rs4253773; rs135547; rs129600; rs4253681; rs4253652; rs135552; rs135539; rs135542; rs4253655; rs12330015; rs9627046; rs135538; rs4253663; rs7364220; rs4253620; rs4253698; rs4253781; rs9626729; rs4253758; rs4253699; rs4253630; rs4253682; rs4253703; rs1555208; rs4253701; rs4253622; rs4253704; rs135549; rs4253665; rs4253686; rs4253792; rs6008259; rs4253702; rs4253669; rs135550; rs135543; rs4253621; rs4253788; rs4253678; rs4253695; rs4253791; rs5769177; rs4253674; rs4253671; rs4253641; rs4253624; rs5766696; rs4253639; rs4253618; rs7286168; rs4253786; rs4253784; rs4253651; rs4253757; rs4253800; rs8138102; rs4253635; rs4253670; rs4253789; rs11704856; rs4253660; rs4253645; rs9626736; rs4253797; rs135540; rs4253638; rs4253694; rs8135690; rs4253633; rs4253627; rs4253642; rs4253696; rs4253656; rs4253706; rs4253659; rs4253672; rs4253691; rs4253667; rs9306498; rs5766698; rs4253688; rs4253623; rs4253634; rs4253801; rs1055659; rs135548; rs4253687; rs4253707; rs4253646; rs6008970; rs4253664; rs4253643; rs4253700; rs4253668; rs135555; rs4253685; rs4253640; rs6008976; rs7287085; rs4253705; rs3892755; rs4253661; rs4253626; rs4253637; rs4253658; rs4253629; rs4253782; rs4253647; rs7289836; rs4253679; rs135551; rs4253793; rs4253617; rs4253692; rs4253631; rs4253644; rs4253625; rs9306499; rs4253790; rs4253787; rs4253683; rs4253619; rs4253662; rs4253657; rs5769178; rs4253756; rs4253684; rs4253636; rs135554; rs4253785; rs4253628; rs9626737; rs4253780; rs4253654; rs4253677; rs761543; rs4253783; rs4253648; rs11704979; rs4253680; rs4253616; rs9626814; rs4253653; rs4253693; rs4253673; rs4253632; rs4253650; rs4253689; rs11913649; rs4253666; rs4823902; rs11704508; rs5769243; rs10427717; rs8135547; rs9680739; rs8139731; rs17661656; rs3747246; rs41367645; rs17661718; rs9306500; rs5766804; rs135553; rs41388244; rs9615264; rs16994933; rs41427746; rs16994915; rs6007981; rs17241878; rs10154348; rs12162684; rs11705154; rs11703495; rs135541; rs12160659; rs7287027; rs4823586; rs6009111; rs41378347; rs12169296; rs135545; rs1134224; rs10775794; rs11703746; rs135536; rs9680676; rs12169290; rs9627268; rs5769366; rs17241885; rs7288994; rs9627100; rs7289495; rs1055657; rs6009081; rs135546; rs1800246; rs5767743; rs4253762; rs4253778; rs4253690; rs4823613; rs4253769; rs4253751; rs6008197; rs6519979; rs4253761; rs4253747; rs4253730; rs4253775; rs4253713; rs4253719; rs4253750; rs4253764; rs4253765; rs4253776; rs4253729; rs4253709; rs4253712; rs4253760; rs4253728; rs11090819; rs4253737; rs4253770; rs4253777; rs2336904; rs4253711; rs4253754; rs4253798; rs4253748; rs4253727; rs4253723; rs4253710; rs4253714; rs6008160; rs4253708; rs4253718; rs4253774; rs4253722; rs4253767; rs4253732; rs5766741; rs4253726; rs4253799; rs5767700; rs7364297; rs4253736; rs4253794; rs4253752; rs4253731; rs4253766; rs4253721; rs4253717; rs4253742; rs4253744; rs4253697; rs4253771; rs4253746; rs4253725; rs4253739; rs4253720; rs4253738; rs4253755; rs1800245; rs4253795; rs4253716; rs4253735; rs4253734; rs5766743; rs4253779; rs4253741; rs4253753; rs6007662; rs4253768; rs4253743; rs4253745; rs4253772; rs4253763; rs4253724; rs4253759; rs4253733; rs4253715; rs8139794; rs4253740; rs4253749; rs8139663; rs41397552; rs11090791; rs11702902; rs11090817; rs6008123; rs7291727; rs5769175; rs5767636; rs9615238; rs5767560; rs5766734; rs6008126; rs5767633; rs11090818; rs8140236; rs12170204; rs9626730; rs11705483; rs11913971; rs7292459; rs5767634; rs4823477; rs6413511; rs1800243; rs1800242; rs9615759; rs1042311; rs5767686; rs1800236; rs12167302; rs9615163; rs41418950; rs34666721; rs5769287; rs35328780; rs7292112; rs11383159; rs7364140; rs5769365; rs34148860; rs5845740; rs35404482; rs35249750; rs41403648; rs35988564; rs6009112; rs5845739; rs36096470; rs41532849; rs881740; rs9615524; rs7286871; rs12484245; rs13053358; rs11538240; rs35966870; rs34896841; rs35838035; rs10643430; rs13053293; rs5767779; rs12171095; rs41479847; rs28772875; rs6009058; rs4592961; rs9627007; rs34109484; rs12159525; rs12170381; rs5845741; rs135544; rs41406451; rs35398060; rs28369325; rs5769129; rs12160049; rs34857047; rs12159225; rs6008042; rs7364165; rs10561065; rs7289761; rs5769184; rs9626764; rs12159821; rs5766682; rs41362646; rs41465647; rs3840962; rs5769088; rs41371446; rs2238833; rs4823487; rs9626756; rs7290774; rs41368348; rs5769276; rs34001104; rs35552991; rs28716636; rs13055301; rs5767424; rs12167354; rs1055658; rs41477146; rs5769364; rs36096495; rs5769356; rs35281820; rs35038216; rs41371949; rs5769142; rs11703765; rs35808855; rs6009014; rs41489145; rs9626751; rs135537; rs41355347; rs34437230; rs9615534; rs6007965; rs12159097; rs9615784; rs11344804; rs5769219; rs9615523; rs16994976; rs9626716; rs28895660; rs41329344; rs35345592; rs41489148; rs1800244; rs13054427; rs11912612; rs11703766; rs36124248; rs12166902; rs6008974; rs13055320; rs5769112; rs41332048; rs12169623; rs5769206; rs36074474; rs35436527; rs13056945; rs8139926; rs9627217; rs6008089; rs10570542; rs34977841; rs11325484; rs35637220; rs9615694; rs17847852; rs4365564; rs5767667; rs8135879; rs12166737; rs5767617; rs5766714; rs9626745; rs2336905; rs6008193; rs9615695; rs7290878; rs1973929; rs28875881; rs41526048; rs35528985; rs12168403; rs34108706; rs34716781; rs9626811; rs41461946; rs12168939; rs6008129; rs34902389; rs12166868; rs10563623; rs10427969; rs8141725; rs4365565; rs5767650; rs34142992; rs9627047; rs7290473; rs5767708; rs6008149; rs34052175; rs11703314; rs6008161; rs10593071; rs35418581; rs11445888; rs35658961; rs34873839; rs10658167; rs41497148; rs35027666; rs6008116; rs34774436; rs11270575; rs34036883; rs35700219; rs6008093; rs6007639; rs13057868; rs28669215; rs11332243; rs41343752; rs28508200; rs2283673; rs5767618; rs28786744; rs10591809; rs12170430; rs12168830; rs12167549; rs34858419; rs13058348; rs8141442; rs6008191; rs6008096; rs5767763; rs35145000; rs28584795; rs6007673; rs7286742; rs12168937; rs28828403; rs35615646; rs34406573; rs13058552; rs6008130; rs12166556; rs13056831; rs9626742; rs34363509; rs9615487; rs5767320; rs34775146; rs9626709; rs12157295; rs10154668; rs1053332; rs11705226; rs12106599; rs12159251; rs135556; rs135557; rs135559; rs135560; rs135561; rs135562; rs14842; rs14843; rs16995065; rs16995067; rs16995069; rs5767842; rs6008923; rs717926; rs7284616; rs7289611; rs7291028; rs9626816; rs9626823; rs9627278; rs9627280; rs9627281; rs9627287

# Macromolecular_Interacting_Partner_16_General_References:
7684926; 7981125; 8993548; 10591208; 9238002; 10681503

# Macromolecular_Interacting_Partner_16_References:
17017903; 17073767; 17110604; 17126302

# Macromolecular_Interacting_Partner_17_ID:
7722

# Macromolecular_Interacting_Partner_17_Name:
Scavenger receptor class B member 1

# Macromolecular_Interacting_Partner_17_Synonyms:
SRB1; SR-BI; CD36 antigen-like 1; CD36 and LIMPII analogous 1; CLA-1; Collagen type I receptor, thrombospondin receptor-like 1

# Macromolecular_Interacting_Partner_17_Gene_Name:
SCARB1

# Macromolecular_Interacting_Partner_17_Protein_Sequence:
>Scavenger receptor class B member 1
MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIP
IPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQ
FQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIM
WGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGL
SKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYR
FVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTG
LHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESG
AMEGETLHTFYTQLVLMPKVMHYAQYVLLALGCVLLLVPVICQIRSQVGAGQRAARADSH
SLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLE
GLGPSLGGGTGS

# Macromolecular_Interacting_Partner_17_Number_of_Residues:
552

# Macromolecular_Interacting_Partner_17_Molecular_Weight:
60879

# Macromolecular_Interacting_Partner_17_Theoretical_pI:
8.31

# Macromolecular_Interacting_Partner_17_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular process
Process:  cell adhesion
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_17_General_Function:
Not Available

# Macromolecular_Interacting_Partner_17_Specific_Function:
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate

# Macromolecular_Interacting_Partner_17_Pathway:
Not Available

# Macromolecular_Interacting_Partner_17_Reaction:
Not Available

# Macromolecular_Interacting_Partner_17_Pfam_Domain_Function:
PF01130:CD36

# Macromolecular_Interacting_Partner_17_Signals:
1-25

# Macromolecular_Interacting_Partner_17_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_17_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_17_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_17_GenBank_ID_Protein:
397607

# Macromolecular_Interacting_Partner_17_SwissProt_ID:
SCRB1_HUMAN (Q8WTV0)

# Macromolecular_Interacting_Partner_17_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_17_Genecard_id:
SCARB1

# Macromolecular_Interacting_Partner_17_Geneatlas_id:
SCARB1

# Macromolecular_Interacting_Partner_17_hgnc_id:
HGNC:1664

# Macromolecular_Interacting_Partner_17_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_17_Subcellular_Location:
Cell membrane; multi-pass membrane protein. Cell membrane; caveola; multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin- enriched domains within the plasma membrane, called caveolae

# Macromolecular_Interacting_Partner_17_Gene_Sequence:
>1530 bp
ATGGGCTGCTCCGCCAAAGCGCGCTGGGCTGCCGGGGCGCTGGGCGTCGCGGGGCTACTG
TGCGCTGTGCTGGGCGCTGTCATGATCGTGATGGTGCCGTCGCTCATCAAGCAGCAGGTC
CTTAAGAACGTGCGCATCGACCCCAGTAGCCTGTCCTTCAACATGTGGAAGGAGATCCCT
ATCCCCTTCTATCTCTCCGTCTACTTCTTTGACGTCATGAACCCCAGCGAGATCCTGAAG
GGCGAGAAGCCGCAGGTGCGGGAGCGCGGGCCCTACGTGTACAGGGAGTCCAGGCACAAA
AGCAACATCACCTTCAACAACAACGACACCGTGTCCTTCCTCGAGTACCGCACCTTCCAG
TTCCAGCCCTCCAAGTCCCACGGCTCGGAGAGCGACTACATCGTCATGCCCAACATCCTG
GTCTTGGGTGCGGCGGTGATGATGGAGAATAAGCCCATGACCCTGAAGCTCATCATGACC
TTGGCATTCACCACCCTCGGCGAACGTGCCTTCATGAACCGCACTGTGGGTGAGATCATG
TGGGGCTACAAGGACCCCCTTGTGAATCTCATCAACAAGTACTTTCCAGGCATGTTCCCC
TTCAAGGACAAGTTCGGATTATTTGCTGAGCTCAACAACTCCGACTCTGGGCTCTTCACG
GTGTTCACGGGGGTCCAGAACATCAGCAGGATCCACCTCGTGGACAAGTGGAACGGGCTG
AGCAAGGTTGACTTCTGGCATTCCGATCAGTGCAACATGATCAATGGAACTTCTGGGCAA
ATGTGGCCGCCCTTCATGACTCCTGAGTCCTCGCTGGAGTTCTACAGCCCGGAGGCCTGC
CGATCCATGAAGCTAATGTACAAGGAGTCAGGGGTGTTTGAAGGCATCCCCACCTATCGC
TTCGTGGCTCCCAAAACCCTGTTTGCCAACGGGTCCATCTACCCACCCAACGAAGGCTTC
TGCCCGTGCCTGGAGTCTGGAATTCAGAACGTCAGCACCTGCAGGTTCAGTGCCCCCTTG
TTTCTCTCCCATCCTCACTTCCTCAACGCCGACCCGGTTCTGGCAGAAGCGGTGACTGGC
CTGCACCCTAACCAGGAGGCACACTCCTTGTTCCTGGACATCCACCCGGTCACGGGAATC
CCCATGAACTGCTCTGTGAAACTGCAGCTGAGCCTCTACATGAAATCTGTCGCAGGCATT
GGACAAACTGGGAAGATTGAGCCTGTGGTCCTGCCGCTGCTCTGGTTTGCAGAGAGCGGG
GCCATGGAGGGGGAGACTCTTCACACATTCTACACTCAGCTGGTGTTGATGCCCAAGGTG
ATGCACTATGCCCAGTACGTCCTCCTGGCGCTGGGCTGCGTCCTGCTGCTGGTCCCTGTC
ATCTGCCAAATCCGGAGCCAAGAGAAATGCTATTTATTTTGGAGTAGTAGTAAAAAGGGC
TCAAAGGATAAGGAGGCCATTCAGGCCTATTCTGAATCCCTGATGACATCAGCTCCCAAG
GGCTCTGTGCTGCAGGAAGCAAAACTGTAG

# Macromolecular_Interacting_Partner_17_GenBank_ID_Gene:
Z22555

# Macromolecular_Interacting_Partner_17_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_17_Locus:
12q24.31

# Macromolecular_Interacting_Partner_17_SNPs:
rs4238001; rs10396213; rs5891; rs5888; rs5889; rs5892; rs2070242; rs701106; rs838886; rs12424178; rs701103; rs921919; rs10846734; rs7977729; rs701104; rs838887; rs3741521; rs838889; rs3825140; rs701105; rs838888; rs7969287; rs10396211; rs33990033; rs747155; rs11057818; rs1726374; rs4765611; rs1902569; rs7301120; rs1672879; rs838895; rs961169; rs2343394; rs4765621; rs838867; rs6488942; rs838862; rs4765179; rs838891; rs838896; rs4765618; rs838866; rs838861; rs7137923; rs3924313; rs838911; rs2293439; rs10773111; rs10773107; rs838892; rs7954697; rs11615630; rs4765622; rs4765624; rs961170; rs838865; rs10846743; rs7137797; rs4765626; rs4765180; rs989892; rs745529; rs7135223; rs4765178; rs701107; rs838900; rs2293440; rs4765617; rs897715; rs2272310; rs4765616; rs838905; rs4765181; rs4765614; rs838907; rs1031605; rs10744179; rs33924155; rs10846739; rs12580803; rs858155; rs10773112; rs7306660; rs10846749; rs10744182; rs7306510; rs4765623; rs7484836; rs838864; rs838897; rs7954519; rs12582221; rs7138304; rs7488092; rs12819677; rs838893; rs4765615; rs838912; rs10846744; rs6488944; rs7139401; rs7967521; rs10846737; rs12580323; rs11057838; rs9919713; rs3782287; rs12581963; rs11608336; rs11057851; rs12229555; rs10773109; rs11057841; rs10773114; rs838906; rs10846748; rs4765619; rs2278986; rs10846738; rs10846736; rs10846751; rs10773115; rs838863; rs865716; rs7312832; rs7134858; rs10846745; rs12231837; rs6488943; rs7135117; rs858156; rs7967406; rs7488791; rs10846747; rs838894; rs838913; rs12582708; rs11057849; rs10773110; rs7303805; rs10773106; rs6488945; rs10846754; rs10846735; rs838890; rs11057846; rs10744180; rs12425800; rs11057826; rs10773105; rs1726329; rs11057864; rs35522120; rs866793; rs10846756; rs12310272; rs4038311; rs11057828; rs12297372; rs838909; rs7967975; rs35472213; rs12424748; rs12829784; rs11057868; rs12425134; rs35663553; rs10396210; rs34810640; rs7485656; rs12319059; rs35905698; rs10846742; rs838902; rs9919736; rs35126387; rs7953717; rs11057860; rs36206381; rs34528590; rs10773116; rs11057833; rs10846740; rs10846752; rs10744183; rs12423301; rs838868; rs1672880; rs7138492; rs897717; rs838904; rs7136506; rs34335701; rs34628266; rs11057844; rs35902723; rs7954022; rs11612448; rs4765613; rs7488127; rs12831105; rs11057866; rs7306507; rs34042305; rs34570542; rs34520556; rs844427; rs12316176; rs10744181; rs4765612; rs7961631; rs11834185; rs36206379; rs12370382; rs11057825; rs35712179; rs838898; rs10846755; rs11057848; rs12422357; rs7296780; rs7486633; rs7297879; rs7307671; rs7967132; rs4765610; rs7487105; rs11057830; rs11057856; rs10846741; rs4371014; rs7305310; rs11057820; rs7137562; rs12578209; rs10846757; rs2003974; rs838908; rs35835693; rs4765620; rs11057861; rs7296737; rs7957364; rs10846758; rs7487945; rs11832116; rs7958037; rs11057845; rs7313793; rs7487965; rs34350939; rs838903; rs35833789; rs11057852; rs11609859; rs34154715; rs11057842; rs11608501; rs12427073; rs33999376; rs3215351; rs10846753; rs11057854; rs11057839; rs7138386; rs11057824; rs34382249; rs838880; rs838884; rs838881; rs838879; rs838883; rs838882; rs838878; rs12580521; rs1672877; rs838877; rs1726339; rs4569100; rs11555540; rs5890; rs10396208; rs10396214; rs747157; rs36045331; rs1059496; rs1059413; rs34358636; rs28479919; rs34193168; rs2037748; rs34730382; rs838910; rs12299310; rs35670604; rs7138175; rs35377987; rs2694826; rs34541150; rs12318140; rs1809225; rs5801572; rs11057836; rs34048880; rs11296472; rs11057857; rs11057863; rs11057850; rs10396212; rs8181745; rs7308931; rs12305535; rs35292065; rs7964517; rs11830613; rs734611; rs10591427; rs6416293; rs36106473; rs34095915; rs28710166; rs11057840; rs12308299; rs12827828; rs33954425; rs34324827; rs11057859; rs11057821; rs36206378; rs10128951; rs11503024; rs7484837; rs28417586; rs12297430; rs730327; rs10636464; rs35311421; rs11615581; rs1814575; rs34417264; rs35186893; rs35493086; rs12305159; rs11057853; rs12369752; rs4765177; rs34137827; rs34705104; rs34840796; rs12427061; rs12303642; rs34041907; rs35207646; rs12810444; rs730329; rs3043265; rs8181743; rs34752148; rs11057855; rs34785993; rs5801570; rs34430339; rs11057831; rs35647985; rs34257636; rs11057823; rs35857542; rs11057814; rs34400797; rs35069983; rs12822440; rs7487704; rs11354008; rs35519068; rs11057865; rs34061026; rs12824656; rs35544896; rs35169101; rs12369712; rs5801576; rs10688374; rs12305799; rs11057837; rs36116402; rs34330640; rs11411007; rs7298209; rs12314270; rs34815648; rs11057815; rs34280489; rs4470001; rs7301720; rs838899; rs34678582; rs7975959; rs35518529; rs12229372; rs12372150; rs35631980; rs28854322; rs11057835; rs11057827; rs1672907; rs28497805; rs11057869; rs838901; rs10584624; rs35525864; rs11316544; rs12230146; rs35799687; rs838915; rs34496229; rs11316190; rs8181746; rs5801574; rs10846750; rs7138729; rs34829203; rs11057862; rs34178546; rs12303278; rs4765176; rs34543026; rs11057817; rs11057822; rs35908611; rs7485628; rs5801571; rs11057829; rs34110612; rs34767647; rs12296148; rs730328; rs35240160; rs11057834; rs34224978; rs33997405; rs7296984; rs7305485; rs4765627; rs7954651; rs35469755; rs12815486; rs35607122; rs11057816; rs35234576; rs5801573; rs12426983; rs34801678; rs1672875; rs35297518; rs11608705; rs4597160; rs6416292; rs35091006; rs4765625; rs4765609; rs12304950; rs11357520; rs11414045; rs34388341; rs863381; rs7484613; rs34231251; rs35618034; rs34399476; rs11057847; rs10692614; rs12299797; rs34905049; rs7138721; rs12228068; rs11300230; rs35290806; rs36226282; rs35766250; rs11057870; rs36226280; rs36226278; rs36226544; rs12322330; rs36226276; rs2124846; rs36226283; rs35859499; rs36226277; rs35352289; rs10846760; rs10846761; rs10846763; rs11057811; rs11057874; rs11057875; rs11834751; rs12228720; rs34840869; rs35794928; rs4379922; rs4765607; rs4765633; rs6488950; rs7315890; rs838876

# Macromolecular_Interacting_Partner_17_General_References:
7689561; 12356718; 12016218; 12913001; 12519372; 12966036

# Macromolecular_Interacting_Partner_17_References:
16946130; 16981711; 17030070; 17034364

# Macromolecular_Interacting_Partner_18_ID:
7803

# Macromolecular_Interacting_Partner_18_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_18_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_18_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_18_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_18_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_18_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_18_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_18_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_18_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_18_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_18_Pathway:
Not Available

# Macromolecular_Interacting_Partner_18_Reaction:
Not Available

# Macromolecular_Interacting_Partner_18_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_18_Signals:
None

# Macromolecular_Interacting_Partner_18_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_18_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_18_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_18_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_18_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_18_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_18_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_18_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_18_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_18_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_18_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_18_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_18_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_18_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_18_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_18_SNPs:
Not Available

# Macromolecular_Interacting_Partner_18_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_18_References:
17029589; 17105204; 17142104

# Macromolecular_Interacting_Partner_19_ID:
8371

# Macromolecular_Interacting_Partner_19_Name:
Multidrug resistance protein 1

# Macromolecular_Interacting_Partner_19_Synonyms:
ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD243 antigen

# Macromolecular_Interacting_Partner_19_Gene_Name:
ABCB1

# Macromolecular_Interacting_Partner_19_Protein_Sequence:
>Multidrug resistance protein 1
MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAII
HGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSG
IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS
KINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFT
DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG
AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARG
AAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSG
QTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLF
ATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA
IARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAG
FDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRS
SLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAII
NGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKA
GEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNI
ANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEA
IENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFG
AYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDS
YSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVV
QLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVV
SQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLD
EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL
LAQKGIYFSMVSVQAGTKRQ

# Macromolecular_Interacting_Partner_19_Number_of_Residues:
1280

# Macromolecular_Interacting_Partner_19_Molecular_Weight:
141464

# Macromolecular_Interacting_Partner_19_Theoretical_pI:
9.44

# Macromolecular_Interacting_Partner_19_GO_Classification:
>>>
Function:  ATPase activity
Function:  hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Function:  ATPase activity, coupled to transmembrane movement of substances
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_19_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_19_Specific_Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells

# Macromolecular_Interacting_Partner_19_Pathway:
Not Available

# Macromolecular_Interacting_Partner_19_Reaction:
ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)

# Macromolecular_Interacting_Partner_19_Pfam_Domain_Function:
PF00664:ABC_membrane;
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_19_Signals:
None

# Macromolecular_Interacting_Partner_19_Transmembrane_Regions:
52-72
120-140
189-209
216-236
297-317
326-346
711-731
757-777
833-853
854-874
937-957
974-994

# Macromolecular_Interacting_Partner_19_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_19_EC_Link:
EC 3.6.3.44

# Macromolecular_Interacting_Partner_19_GenBank_ID_Protein:
307180

# Macromolecular_Interacting_Partner_19_SwissProt_ID:
MDR1_HUMAN (P08183)

# Macromolecular_Interacting_Partner_19_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_19_Genecard_id:
ABCB1

# Macromolecular_Interacting_Partner_19_Geneatlas_id:
ABCB1

# Macromolecular_Interacting_Partner_19_hgnc_id:
HGNC:40

# Macromolecular_Interacting_Partner_19_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_19_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_19_Gene_Sequence:
>3843 bp
ATGGATCTTGAAGGGGACCGCAATGGAGGAGCAAAGAAGAAGAACTTTTTTAAACTGAAC
AATAAAAGTGAAAAAGATAAGAAGGAAAAGAAACCAACTGTCAGTGTATTTTCAATGTTT
CGCTATTCAAATTGGCTTGACAAGTTGTATATGGTGGTGGGAACTTTGGCTGCCATCATC
CATGGGGCTGGACTTCCTCTCATGATGCTGGTGTTTGGAGAAATGACAGATATCTTTGCA
AATGCAGGAAATTTAGAAGATCTGATGTCAAACATCACTAATAGAAGTGATATCAATGAT
ACAGGGTTCTTCATGAATCTGGAGGAAGACATGACCAGGTATGCCTATTATTACAGTGGA
ATTGGTGCTGGGGTGCTGGTTGCTGCTTACATTCAGGTTTCATTTTGGTGCCTGGCAGCT
GGAAGACAAATACACAAAATTAGAAAACAGTTTTTTCATGCTATAATGCGACAGGAGATA
GGCTGGTTTGATGTGCACGATGTTGGGGAGCTTAACACCCGACTTACAGATGATGTCTCT
AAGATTAATGAAGTTATTGGTGACAAAATTGGAATGTTCTTTCAGTCAATGGCAACATTT
TTCACTGGGTTTATAGTAGGATTTACACGTGGTTGGAAGCTAACCCTTGTGATTTTGGCC
ATCAGTCCTGTTCTTGGACTGTCAGCTGCTGTCTGGGCAAAGATACTATCTTCATTTACT
GATAAAGAACTCTTAGCGTATGCAAAAGCTGGAGCAGTAGCTGAAGAGGTCTTGGCAGCA
ATTAGAACTGTGATTGCATTTGGAGGACAAAAGAAAGAACTTGAAAGGTACAACAAAAAT
TTAGAAGAAGCTAAAAGAATTGGGATAAAGAAAGCTATTACAGCCAATATTTCTATAGGT
GCTGCTTTCCTGCTGATCTATGCATCTTATGCTCTGGCCTTCTGGTATGGGACCACCTTG
GTCCTCTCAGGGGAATATTCTATTGGACAAGTACTCACTGTATTCTTTTCTGTATTAATT
GGGGCTTTTAGTGTTGGACAGGCATCTCCAAGCATTGAAGCATTTGCAAATGCAAGAGGA
GCAGCTTATGAAATCTTCAAGATAATTGATAATAAGCCAAGTATTGACAGCTATTCGAAG
AGTGGGCACAAACCAGATAATATTAAGGGAAATTTGGAATTCAGAAATGTTCACTTCAGT
TACCCATCTCGAAAAGAAGTTAAGATCTTGAAGGGCCTGAACCTGAAGGTGCAGAGTGGG
CAGACGGTGGCCCTGGTTGGAAACAGTGGCTGTGGGAAGAGCACAACAGTCCAGCTGATG
CAGAGGCTCTATGACCCCACAGAGGGGATGGTCAGTGTTGATGGACAGGATATTAGGACC
ATAAATGTAAGGTTTCTACGGGAAATCATTGGTGTGGTGAGTCAGGAACCTGTATTGTTT
GCCACCACGATAGCTGAAAACATTCGCTATGGCCGTGAAAATGTCACCATGGATGAGATT
GAGAAAGCTGTCAAGGAAGCCAATGCCTATGACTTTATCATGAAACTGCCTCATAAATTT
GACACCCTGGTTGGAGAGAGAGGGGCCCAGTTGAGTGGTGGGCAGAAGCAGAGGATCGCC
ATTGCACGTGCCCTGGTTCGCAACCCCAAGATCCTCCTGCTGGATGAGGCCACGTCAGCC
TTGGACACAGAAAGCGAAGCAGTGGTTCAGGTGGCTCTGGATAAGGCCAGAAAAGGTCGG
ACCACCATTGTGATAGCTCATCGTTTGTCTACAGTTCGTAATGCTGACGTCATCGCTGGT
TTCGATGATGGAGTCATTGTGGAGAAAGGAAATCATGATGAACTCATGAAAGAGAAAGGC
ATTTACTTCAAACTTGTCACAATGCAGACAGCAGGAAATGAAGTTGAATTAGAAAATGCA
GCTGATGAATCCAAAAGTGAAATTGATGCCTTGGAAATGTCTTCAAATGATTCAAGATCC
AGTCTAATAAGAAAAAGATCAACTCGTAGGAGTGTCCGTGGATCACAAGCCCAAGACAGA
AAGCTTAGTACCAAAGAGGCTCTGGATGAAAGTATACCTCCAGTTTCCTTTTGGAGGATT
ATGAAGCTAAATTTAACTGAATGGCCTTATTTTGTTGTTGGTGTATTTTGTGCCATTATA
AATGGAGGCCTGCAACCAGCATTTGCAATAATATTTTCAAAGATTATAGGGGTTTTTACA
AGAATTGATGATCCTGAAACAAAACGACAGAATAGTAACTTGTTTTCACTATTGTTTCTA
GCCCTTGGAATTATTTCTTTTATTACATTTTTCCTTCAGGGTTTCACATTTGGCAAAGCT
GGAGAGATCCTCACCAAGCGGCTCCGATACATGGTTTTCCGATCCATGCTCAGACAGGAT
GTGAGTTGGTTTGATGACCCTAAAAACACCACTGGAGCATTGACTACCAGGCTCGCCAAT
GATGCTGCTCAAGTTAAAGGGGCTATAGGTTCCAGGCTTGCTGTAATTACCCAGAATATA
GCAAATCTTGGGACAGGAATAATTATATCCTTCATCTATGGTTGGCAACTAACACTGTTA
CTCTTAGCAATTGTACCCATCATTGCAATAGCAGGAGTTGTTGAAATGAAAATGTTGTCT
GGACAAGCACTGAAAGATAAGAAAGAACTAGAAGGTGCTGGGAAGATCGCTACTGAAGCA
ATAGAAAACTTCCGAACCGTTGTTTCTTTGACTCAGGAGCAGAAGTTTGAACATATGTAT
GCTCAGAGTTTGCAGGTACCATACAGAAACTCTTTGAGGAAAGCACACATCTTTGGAATT
ACATTTTCCTTCACCCAGGCAATGATGTATTTTTCCTATGCTGGATGTTTCCGGTTTGGA
GCCTACTTGGTGGCACATAAACTCATGAGCTTTGAGGATGTTCTGTTAGTATTTTCAGCT
GTTGTCTTTGGTGCCATGGCCGTGGGGCAAGTCAGTTCATTTGCTCCTGACTATGCCAAA
GCCAAAATATCAGCAGCCCACATCATCATGATCATTGAAAAAACCCCTTTGATTGACAGC
TACAGCACGGAAGGCCTAATGCCGAACACATTGGAAGGAAATGTCACATTTGGTGAAGTT
GTATTCAACTATCCCACCCGACCGGACATCCCAGTGCTTCAGGGACTGAGCCTGGAGGTG
AAGAAGGGCCAGACGCTGGCTCTGGTGGGCAGCAGTGGCTGTGGGAAGAGCACAGTGGTC
CAGCTCCTGGAGCGGTTCTACGACCCCTTGGCAGGGAAAGTGCTGCTTGATGGCAAAGAA
ATAAAGCGACTGAATGTTCAGTGGCTCCGAGCACACCTGGGCATCGTGTCCCAGGAGCCC
ATCCTGTTTGACTGCAGCATTGCTGAGAACATTGCCTATGGAGACAACAGCCGGGTGGTG
TCACAGGAAGAGATCGTGAGGGCAGCAAAGGAGGCCAACATACATGCCTTCATCGAGTCA
CTGCCTAATAAATATAGCACTAAAGTAGGAGACAAAGGAACTCAGCTCTCTGGTGGCCAG
AAACAACGCATTGCCATAGCTCGTGCCCTTGTTAGACAGCCTCATATTTTGCTTTTGGAT
GAAGCCACGTCAGCTCTGGATACAGAAAGTGAAAAGGTTGTCCAAGAAGCCCTGGACAAA
GCCAGAGAAGGCCGCACCTGCATTGTGATTGCTCACCGCCTGTCCACCATCCAGAATGCA
GACTTAATAGTGGTGTTTCAGAATGGCAGAGTCAAGGAGCATGGCACGCATCAGCAGCTG
CTGGCACAGAAAGGCATCTATTTTTCAATGGTCAGTGTCCAGGCTGGAACAAAGCGCCAG
TGA

# Macromolecular_Interacting_Partner_19_GenBank_ID_Gene:
M14758

# Macromolecular_Interacting_Partner_19_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_19_Locus:
7q21.1

# Macromolecular_Interacting_Partner_19_SNPs:
rs2032582; rs2229107; rs2229109; rs9282565; rs9282564; rs1202183; rs28364274; rs28401798; rs1045642; rs1128503; rs34748655; rs9282563; rs2235051; rs2235012; rs2188524; rs4728709; rs2214102; rs3213619; rs28381802; rs4148730; rs17149824; rs12720464; rs28364275; rs28381800; rs17328260; rs12536690; rs17328288; rs4148731; rs1978095; rs28381792; rs28381776; rs28381783; rs28381778; rs17328198; rs28381789; rs28381774; rs28364277; rs13233308; rs28381799; rs28381777; rs17149810; rs28381801; rs28364278; rs28381790; rs28381796; rs28381780; rs28381772; rs28381795; rs12668917; rs28381797; rs17064; rs28381787; rs28381781; rs28364279; rs28381771; rs28746504; rs28381779; rs28381773; rs3214119; rs3842; rs28381782; rs12671453; rs28381794; rs11395081; rs28381785; rs2235052; rs4148732; rs28381791; rs28381775; rs17149813; rs28381784; rs2091766; rs1202168; rs1202172; rs1202186; rs1002205; rs1922240; rs1882478; rs1202179; rs1202181; rs2520464; rs2235046; rs2235013; rs1882479; rs1202185; rs4148738; rs2373587; rs4148744; rs6961419; rs2235019; rs1202171; rs7779562; rs10236274; rs10244266; rs4148737; rs4148736; rs10264990; rs3789244; rs1989830; rs4148750; rs10274587; rs956825; rs7787082; rs4148751; rs12539098; rs10268314; rs6952752; rs1186745; rs7787569; rs7795817; rs2235049; rs1202184; rs10248420; rs1202170; rs2235067; rs1202167; rs2141849; rs1202169; rs6949448; rs1202166; rs6961882; rs4148740; rs1202182; rs4437575; rs1211433; rs1882477; rs4148745; rs10225464; rs7802773; rs2235074; rs10276036; rs1922242; rs12704364; rs11975994; rs2235048; rs6961665; rs1922243; rs4148743; rs6980101; rs2235035; rs4148735; rs10260862; rs4148733; rs6950978; rs1016794; rs1202178; rs1202174; rs2032584; rs10256836; rs955000; rs2373588; rs11983225; rs12720066; rs10274441; rs6946379; rs12535512; rs11763872; rs2235033; rs6961417; rs12673269; rs10274623; rs12668877; rs12154941; rs10263741; rs10244116; rs1002204; rs1922241; rs10280101; rs12720067; rs17149754; rs2888599; rs2214104; rs10259849; rs10276603; rs2235018; rs4148742; rs4148739; rs2235026; rs28381837; rs10234411; rs10808072; rs1202175; rs10240953; rs11760837; rs2214103; rs4728702; rs1922244; rs17149738; rs1016793; rs11772987; rs6979885; rs3789243; rs2373586; rs2032583; rs10246696; rs11979702; rs1989831; rs2373589; rs2235027; rs2235040; rs17149792; rs6959435; rs6948766; rs1202176; rs17327624; rs4148749; rs868755; rs10808071; rs17327442; rs4728700; rs4728701; rs6978925; rs1858923; rs17131983; rs17149772; rs2235066; rs3789246; rs28381958; rs28401770; rs1211152; rs28381878; rs28381872; rs4728705; rs2235016; rs28381965; rs2032585; rs4148747; rs28401778; rs28381857; rs2235043; rs28746509; rs7787424; rs28381920; rs28381895; rs2235020; rs2235065; rs28381845; rs13226726; rs28381826; rs28381928; rs16706; rs28381905; rs17149699; rs28401802; rs2235014; rs28381827; rs2235028; rs28381957; rs2235042; rs28401784; rs28381929; rs7804127; rs28401815; rs28381809; rs28401779; rs2235070; rs28381931; rs28381839; rs4148734; rs28381877; rs2235015; rs28381884; rs28381939; rs28381919; rs6971264; rs28381866; rs2235034; rs1202177; rs12334183; rs28401776; rs2235045; rs28381868; rs28381946; rs2235023; rs10280623; rs28381831; rs28401816; rs1186746; rs28381855; rs7804128; rs3028303; rs7787421; rs4728699; rs28401819; rs28381892; rs28401796; rs2214105; rs28381963; rs28381944; rs28381908; rs28381885; rs7802257; rs28381816; rs28401809; rs28381807; rs2235069; rs28401777; rs28381820; rs28381817; rs28381832; rs2373585; rs16885829; rs28381886; rs2235075; rs11304553; rs28401801; rs28381962; rs28381875; rs28381907; rs28381850; rs28401782; rs4148746; rs28381887; rs1186744; rs16885833; rs28364273; rs1024409; rs11769518; rs11761122; rs28381861; rs28381869; rs28381880; rs28381853; rs28381924; rs28746505; rs11972405; rs28401805; rs28401799; rs28381940; rs28746510; rs2235021; rs2235047; rs28381838; rs28381842; rs28381961; rs28381848; rs10249333; rs2032588; rs28381876; rs28381916; rs2235024; rs2235064; rs1989829; rs28401788; rs28381909; rs4728707; rs13239201; rs1211151; rs28381947; rs4728706; rs28401806; rs28381960; rs28381903; rs28401814; rs28381934; rs12704363; rs2188526; rs2235063; rs28401820; rs13229143; rs28381852; rs10225473; rs28381863; rs17327942; rs28381873; rs28364271; rs6970380; rs28381825; rs28381847; rs2235030; rs28381840; rs28381819; rs28381814; rs2235050; rs28381862; rs2188525; rs28401817; rs28381917; rs28401812; rs28401797; rs17149790; rs28381910; rs2235041; rs28381911; rs28401792; rs1209054; rs12154319; rs28381883; rs2235029; rs28364270; rs28401773; rs28381856; rs1202180; rs17327747; rs2032586; rs13237132; rs1202173; rs28401781; rs28381922; rs28381950; rs28381841; rs1055302; rs12539997; rs11984161; rs28381914; rs41309225; rs2707944; rs28381804; rs28381902; rs41315618; rs2032581; rs28381967; rs2235039; rs41305517; rs41316450; rs41309231; rs2235036; rs1128501; rs41309228; rs28381867; rs41304191; rs1128502; rs41311775; rs1128500; rs2235044; rs28381915; rs2707943; rs2235022; rs28381966; rs9332385; rs6977171; rs28381788; rs5014440; rs35770463; rs35644241; rs35267921; rs41296639; rs35012650; rs34081055; rs28655259; rs11294617; rs28364281; rs35855743; rs35453635; rs35447943; rs35141338; rs28381798; rs13242633; rs35260049; rs1468149; rs35477648; rs35998786; rs11440098; rs7794477; rs41297363; rs5885591; rs4604363; rs35132449; rs34962462; rs35268090; rs11342943; rs10275895; rs34208689; rs5014439; rs3926353; rs28381786; rs28381793; rs1966313; rs28364280; rs3926352; rs35998484; rs28381803; rs6952798; rs11440100; rs10275536; rs41297348; rs10600037; rs41278761; rs28381815; rs35600470; rs2706100; rs2235025; rs35471539; rs6971424; rs10252821; rs41297360; rs28381906; rs4728697; rs35757402; rs13230066; rs28401785; rs34947426; rs2706098; rs28381951; rs35227154; rs5014436; rs10600040; rs28381921; rs34445246; rs28381836; rs35818141; rs2235072; rs41308867; rs34775842; rs34289914; rs34776171; rs41297351; rs6980354; rs28381871; rs17149783; rs28401790; rs28381890; rs34445458; rs34628915; rs4148752; rs35639555; rs34885273; rs34598903; rs28381899; rs28549812; rs35711803; rs41316453; rs36015329; rs36218788; rs28401807; rs35335128; rs28381844; rs28381854; rs28381927; rs41309234; rs28381833; rs28401795; rs36097582; rs35513721; rs36008665; rs28381900; rs28381870; rs2373590; rs28746508; rs28381964; rs4148741; rs28381828; rs28381829; rs34298931; rs35280822; rs1922238; rs28381834; rs28381953; rs28401793; rs11440096; rs7457890; rs41309222; rs6952359; rs28381952; rs34609577; rs28381913; rs28401786; rs28381808; rs10273964; rs28381851; rs35981891; rs33959732; rs28381941; rs5014438; rs10237477; rs28381888; rs2235062; rs28381897; rs10532925; rs28381901; rs11974399; rs12720440; rs28381821; rs28746507; rs34127337; rs28381954; rs35440979; rs11768388; rs28681479; rs28401794; rs35766168; rs28381945; rs28381932; rs5014437; rs28381959; rs10244525; rs28381943; rs5885590; rs28401813; rs2706099; rs5885589; rs6973406; rs28381935; rs28381904; rs41297354; rs41297345; rs41316456; rs12720069; rs28401803; rs28381818; rs13245606; rs28381948; rs28746506; rs28381898; rs35334908; rs35070592; rs28381891; rs28381810; rs34923788; rs34332398; rs41296636; rs28381933; rs10600038; rs28381806; rs34657813; rs28401774; rs41296633; rs28381822; rs35498006; rs35572298; rs41274218; rs2235017; rs2235073; rs28401775; rs28381811; rs2235038; rs28381860; rs5885588; rs28381874; rs28381955; rs11322711; rs34291906; rs28381936; rs28381894; rs10661738; rs28371078; rs28401821; rs34614047; rs11348505; rs28381881; rs35522790; rs41296630; rs6150207; rs28381823; rs34986820; rs28381843; rs1212957; rs28401804; rs2235032; rs10600039; rs28401811; rs1922237; rs28401768; rs28381805; rs28364268; rs28401783; rs34532729; rs28401787; rs36119114; rs28401791; rs41304188; rs2235037; rs4727148; rs28381893; rs35635932; rs28401772; rs28381812; rs35238388; rs5885587; rs34517102; rs28381882; rs28381956; rs2373591; rs28401808; rs28381835; rs36218789; rs28381858; rs35259034; rs28381937; rs35687466; rs34513210; rs28381865; rs28401780; rs28381923; rs34325451; rs1882480; rs36125978; rs41278758; rs41309219; rs28401800; rs28381830; rs10240853; rs28381824; rs12720070; rs10274054; rs28718458; rs11771798; rs28381925; rs2235071; rs28381912; rs35881718; rs7809208; rs41297357; rs28401769; rs41304194; rs28381864; rs41296642; rs28401771; rs41315621; rs28381879; rs28381942; rs28381859; rs28364272; rs28381930; rs28381918; rs28381949; rs28381849; rs2706101; rs28381926; rs10713802; rs28401789; rs34766508; rs28381889; rs28364269; rs28381938; rs28381813; rs1202165; rs35820221; rs28401818; rs28381846; rs35396007; rs35583835; rs41312547; rs34127828; rs28381896; rs1055304; rs1055305; rs36074739; rs1015415; rs10231033; rs10232449; rs10233247; rs10246878; rs10254392; rs10261685; rs10264856; rs10267099; rs10275831; rs10276499; rs10278483; rs10486996; rs11973812; rs11975403; rs11983274; rs11983624; rs11984283; rs12538707; rs12539395; rs12540931; rs12670317; rs12672720; rs12704366; rs13221839; rs13231229; rs17149840; rs17149850; rs17149854; rs17149864; rs17149866; rs17209837; rs17250003; rs2028026; rs2157926; rs2157928; rs2157929; rs2188528; rs2188530; rs34398291; rs34767983; rs34800935; rs35633772; rs3747802; rs4148727; rs4148728; rs4263684; rs6465118; rs6951067; rs6952194; rs6957599; rs6963426; rs6968274; rs6969155; rs7455204; rs7786524; rs7790722; rs7790798; rs7796247; rs7799907; rs7802783; rs7810499; rs916715; rs9641019; rs998671

# Macromolecular_Interacting_Partner_19_General_References:
2876781; 1967175; 9038218; 12853948; 1972623; 2568832; 11258197; 2897240; 9473242; 10790226; 10716719; 11240981; 11829140

# Macromolecular_Interacting_Partner_19_References:
17029589

# Macromolecular_Interacting_Partner_20_ID:
8323

# Macromolecular_Interacting_Partner_20_Name:
Leupaxin

# Macromolecular_Interacting_Partner_20_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_20_Gene_Name:
LPXN

# Macromolecular_Interacting_Partner_20_Protein_Sequence:
>Leupaxin
MEELDALLEELERSTLQDSDEYSNPAPLPLDQHSRKETNLDETSEILSIQDNTSPLPAQL
VYTTNIQELNVYSEAQEPKESPPPSKTSAAAQLDELMAHLTEMQAKVAVRADAGKKHLPD
KQDHKASLDSMLGGLEQELQDLGIATVPKGHCASCQKPIAGKVIHALGQSWHPEHFVCTH
CKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHC
GEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENYLSAMDTVWHPECFVCGDCF
TSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLT
QLSKGIFREQNDKTYCQPCFNKLFPL

# Macromolecular_Interacting_Partner_20_Number_of_Residues:
386

# Macromolecular_Interacting_Partner_20_Molecular_Weight:
43332

# Macromolecular_Interacting_Partner_20_Theoretical_pI:
5.94

# Macromolecular_Interacting_Partner_20_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_20_General_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Specific_Function:
Associates with PYK2 in lymphoid cells. May regulate signaling at sites of adhesion

# Macromolecular_Interacting_Partner_20_Pathway:
Not Available

# Macromolecular_Interacting_Partner_20_Reaction:
Not Available

# Macromolecular_Interacting_Partner_20_Pfam_Domain_Function:
PF00412:LIM

# Macromolecular_Interacting_Partner_20_Signals:
None

# Macromolecular_Interacting_Partner_20_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_20_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_20_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_20_GenBank_ID_Protein:
3126971

# Macromolecular_Interacting_Partner_20_SwissProt_ID:
LPXN_HUMAN (O60711)

# Macromolecular_Interacting_Partner_20_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_20_Genecard_id:
LPXN

# Macromolecular_Interacting_Partner_20_Geneatlas_id:
LPXN

# Macromolecular_Interacting_Partner_20_hgnc_id:
HGNC:14061

# Macromolecular_Interacting_Partner_20_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_20_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_20_Gene_Sequence:
>1161 bp
ATGGAAGAGTTAGATGCCTTATTGGAGGAACTGGAACGCTCCACCCTTCAGGACAGTGAT
GAATATTCCAACCCAGCTCCTCTTCCCCTGGATCAGCATTCCAGAAAGGAGACTAACCTT
GATGAGACTTCGGAGATCCTTTCTATTCAGGATAACACAAGTCCCTTGCCGGCGCAGCTC
GTGTATACTACCAATATCCAGGAGCTCAATGTCTACAGTGAAGCCCAAGAGCCAAAGGAA
TCACCACCACCTTCTAAAACGTCAGCAGCTGCTCAGTTGGATGAGCTCATGGCTCACCTG
ACTGAGATGCAGGCCAAGGTTGCAGTGAGAGCAGATGCTGGCAAGAAGCACTTACCAGAC
AAGCAGGATCACAAGGCCTCCCTGGACTCAATGCTTGGGGGTCTGGAGCAGGAATTGCAG
GACCTTGGCATTGCCACAGTGCCCAAGGGCCATTGTGCATCCTGCCAGAAACCGATTGCT
GGGAAGGTGATCCATGCTCTAGGGCAATCATGGCATCCTGAGCATTTTGTCTGTACTCAT
TGCAAAGAAGAGATTGGCTCCAGTCCCTTCTTTGAGCGGAGTGGCTTGGCCTACTGCCCC
AACGACTACCACCAACTTTTTTCTCCACGCTGTGCTTACTGCGCTGCTCCCATCCTGGAT
AAAGTGCTGACAGCAATGAACCAGACCTGGCACCCAGAGCACTTCTTCTGCTCTCACTGC
GGAGAGGTGTTTGGTGCAGAAGGCTTTCATGAGAAGGACAAGAAGCCATATTGCCGAAAG
GATTTCTTAGCCATGTTCTCACCCAAGTGTGGTGGCTGCAATCGCCCAGTGTTGGAAAAC
TACCTTTCAGCCATGGACACTGTCTGGCACCCAGAGTGCTTTGTTTGTGGGGACTGCTTC
ACCAGTTTTTCTACTGGCTCCTTCTTTGAACTGGATGGACGTCCATTCTGTGAGCTCCAT
TACCATCACCGCCGGGGAACGCTCTGCCATGGGTGTGGGCAGCCCATCACTGGCCGTTGT
ATCAGTGCCATGGGGTACAAGTTCCATCCTGAGCACTTTGTGTGTGCTTTCTGCCTGACA
CAGTTGTCGAAGGGCATTTTCAGGGAGCAGAATGACAAGACCTATTGTCAACCTTGCTTC
AATAAGCTCTTCCCACTGTAA

# Macromolecular_Interacting_Partner_20_GenBank_ID_Gene:
AF062075

# Macromolecular_Interacting_Partner_20_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_20_Locus:
11q12.1

# Macromolecular_Interacting_Partner_20_SNPs:
rs12271558; rs1047979; rs2509920; rs1944054; rs2515347; rs2276301; rs2515359; rs2515346; rs10896794; rs1944052; rs10792172; rs956658; rs10896792; rs2510549; rs12800710; rs2510550; rs2515361; rs11229519; rs2515349; rs1944055; rs7109553; rs2510552; rs10896791; rs2515348; rs2510551; rs1944053; rs7115061; rs11229525; rs2515360; rs12290872; rs2515358; rs7119594; rs11229529; rs12362218; rs11229524; rs11601687; rs17152733; rs3829218; rs17152724; rs6591480; rs11229528; rs12276093; rs12363738; rs9888176; rs11229523; rs7127636; rs7933361; rs12294453; rs11605297; rs10160409; rs2510555; rs6591479; rs12282976; rs10896788; rs7933838; rs7944812; rs7933979; rs7119625; rs7930869; rs7943544; rs12294582; rs638952; rs17845596; rs1802347; rs11543064; rs11229513; rs2515353; rs35629114; rs35632700; rs11229521; rs33923190; rs4329707; rs35802291; rs11295701; rs7110210; rs5792107; rs7112350; rs5792110; rs34550938; rs12288841; rs12801512; rs34010187; rs34448423; rs11501583; rs954554; rs28853379; rs34104756; rs11512828; rs34889127; rs4581467; rs11229520; rs2510554; rs35694857; rs2515354; rs3133440; rs36143859; rs34133979; rs35802608; rs34901907; rs12284057; rs35386161; rs12282872; rs7131475; rs2515355; rs2510553; rs3793959; rs5792108; rs12271995; rs10574672; rs7108127; rs11229530; rs7128785; rs2515351; rs5792111; rs12290992; rs11229527; rs11229518; rs10617997; rs2515345; rs7129136; rs35219113; rs12418166; rs11426447; rs10683588; rs12790816; rs35962560; rs35744318; rs34205632; rs35277797; rs35717771; rs11229531; rs11560952; rs35452076; rs28636578; rs2515356; rs11413201; rs35819260; rs7128302; rs35101887; rs11229526; rs35711727; rs35426315; rs11229532; rs11229522; rs34402227; rs35138456; rs7943056; rs35870490; rs34675222; rs35665977; rs2515352; rs36141352; rs35912008; rs2515357; rs34073841; rs5792106; rs11413202; rs35895296; rs10541317; rs33951912; rs34461980; rs5792105; rs10750899; rs10750900; rs11229535; rs11229538; rs11601014; rs11605269; rs11605683; rs17145606; rs17152743; rs17152750; rs1944050; rs2510556; rs2515344; rs3763798; rs568290; rs613333; rs613349; rs7124107; rs7483906; rs7943472; rs7945334; rs7952094; rs948562

# Macromolecular_Interacting_Partner_20_General_References:
9565592

# Macromolecular_Interacting_Partner_20_References:
17078215

# Macromolecular_Interacting_Partner_21_ID:
7774

# Macromolecular_Interacting_Partner_21_Name:
Xenotropic and polytropic murine retrovirus receptor

# Macromolecular_Interacting_Partner_21_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_21_Gene_Name:
XPR1

# Macromolecular_Interacting_Partner_21_Protein_Sequence:
>Xenotropic and polytropic murine retrovirus receptor
MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQ
TCEKELAKINTFYSEKLAEAQRRFATLQNELQSSLDAQKESTGVTTLRQRRKPVFHLSHE
ERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVAHV
EVAPFYTCKKINQLISETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLF
CGIFIVLNITLVLAAVFKLETDRSIWPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHV
LIFELNPRSNLSHQHLFEIAGFLGILWCLSLLACFFAPISVIPTYVYPLALYGFMVFFLI
NPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFADFWLADQLNSLSVILMDLEYMICFYSLE
LKWDESKGLLPNNSEESGICHKYTYGVRAIVQCIPAWLRFIQCLRRYRDTKRAFPHLVNA
GKYSTTFFMVAFAALYSTHKERGHSDTMVFFYLWIVFYIISSCYTLIWDLKMDWGLFDKN
AGENTFLREEIVYPQKAYYYCAIIEDVILRFAWTIQISITSTTLLPHSGDIIATVFAPLE
VFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQTLLEQMMDQDDGVRNRQKNRS
WKYNQSISLRRPRLASQSKARDTKVLIEDTDDEANT

# Macromolecular_Interacting_Partner_21_Number_of_Residues:
696

# Macromolecular_Interacting_Partner_21_Molecular_Weight:
81506

# Macromolecular_Interacting_Partner_21_Theoretical_pI:
8.58

# Macromolecular_Interacting_Partner_21_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_21_General_Function:
Signal transduction mechanisms 

# Macromolecular_Interacting_Partner_21_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_21_Pathway:
Not Available

# Macromolecular_Interacting_Partner_21_Reaction:
Not Available

# Macromolecular_Interacting_Partner_21_Pfam_Domain_Function:
PF03124:EXS;
PF03105:SPX

# Macromolecular_Interacting_Partner_21_Signals:
None

# Macromolecular_Interacting_Partner_21_Transmembrane_Regions:
235-257; 270-292; 319-341; 346-368; 474-496; 509-528

# Macromolecular_Interacting_Partner_21_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_21_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_21_GenBank_ID_Protein:
4176766

# Macromolecular_Interacting_Partner_21_SwissProt_ID:
O95719_HUMAN (O95719)

# Macromolecular_Interacting_Partner_21_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_21_Genecard_id:
XPR1

# Macromolecular_Interacting_Partner_21_Geneatlas_id:
XPR1

# Macromolecular_Interacting_Partner_21_hgnc_id:
HGNC:12827

# Macromolecular_Interacting_Partner_21_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_21_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_21_Gene_Sequence:
>2091 bp
ATGAAGTTCGCCGAGCACCTCTCCGCGCACATCACTCCCGAGTGGAGGAAGCAATACATC
CAGTATGAGGCTTTCAAGGATATGCTGTATTCAGCTCAGGACCAGGCACCTTCTGTGGAA
GTTACAGATGAGGACACAGTAAAGAGGTATTTTGCCAAGTTTGAAGAGAAGTTTTTCCAA
ACCTGTGAAAAAGAACTTGCCAAAATCAACACATTTTATTCAGAGAAGCTCGCAGAGGCT
CAGCGCAGGTTTGCTACACTTCAGAATGAGCTTCAGTCATCACTGGATGCACAGAAAGAA
AGCACTGGTGTTACTACGCTGCGACAACGCAGAAAGCCAGTCTTCCACTTGTCCCATGAG
GAACGTGTCCAACATAGAAATATTAAAGACCTTAAACTGGCCTTCAGTGAGTTCTACCTC
AGTCTAATCCTGCTGCAGAACTATCAGAATCTGAATTTTACAGGGTTTCGAAAAATCCTG
AAAAAGCATGACAAGATCCTGGAAACATCTCGTGGAGCAGATTGGCGAGTGGCTCACGTA
GAGGTGGCCCCATTTTATACATGCAAGAAAATCAACCAGCTTATCTCTGAAACTGAGGCT
GTAGTGACCAATGAACTTGAAGATGGTGACAGACAAAAGGCTATGAAGCGTTTACGTGTC
CCCCCTTTGGGAGCTGCTCAGCCTGCACCAGCATGGACTACTTTTAGAGTTGGCCTATTT
TGTGGAATATTCATTGTACTGAATATTACCCTTGTGCTTGCCGCTGTATTTAAACTTGAA
ACAGATAGAAGTATATGGCCCTTGATAAGAATCTATCGGGGTGGCTTTCTTCTGATTGAA
TTCCTTTTTCTACTGGGCATCAACACGTATGGTTGGAGACAGGCTGGAGTAAACCATGTA
CTCATCTTTGAACTTAATCCGAGAAGCAATTTGTCTCATCAACATCTCTTTGAGATTGCT
GGATTCCTCGGGATATTGTGGTGCCTGAGCCTTCTGGCATGCTTCTTTGCTCCAATTAGT
GTCATCCCCACATATGTGTATCCACTTGCCCTTTATGGATTTATGGTTTTCTTCCTTATC
AACCCCACCAAAACTTTCTACTATAAATCCCGGTTTTGGCTGCTTAAACTGCTGTTTCGA
GTATTTACAGCCCCCTTCCATAAGGTAGGCTTTGCTGATTTCTGGCTGGCGGATCAGCTG
AACAGCCTGTCAGTGATACTGATGGACCTGGAATATATGATCTGCTTCTACAGTTTGGAG
CTCAAATGGGATGAAAGTAAGGGCCTGTTGCCAAATAATTCAGAAGAATCAGGAATTTGC
CACAAATATACATATGGTGTGCGGGCCATTGTTCAGTGCATTCCTGCTTGGCTTCGCTTC
ATCCAGTGCCTGCGCCGATATCGAGACACAAAAAGGGCCTTTCCTCATTTAGTTAATGCT
GGCAAGTACTCCACAACTTTCTTCATGGTGGCGTTTGCAGCCCTTTACAGCACTCACAAA
GAACGAGGTCACTCGGACACTATGGTGTTCTTTTACCTGTGGATTGTCTTTTATATCATC
AGTTCCTGCTATACCCTCATCTGGGATCTCAAGATGGACTGGGGTCTCTTCGATAAGAAT
GCTGGAGAGAACACTTTCCTCCGGGAAGAGATTGTATACCCCCAAAAAGCCTACTACTAC
TGTGCCATAATAGAGGATGTGATTCTGCGCTTTGCTTGGACTATCCAAATCTCGATTACC
TCTACAACTTTGTTGCCTCATTCTGGGGACATCATTGCTACTGTCTTTGCCCCACTTGAG
GTTTTCCGGCGATTTGTGTGGAACTTCTTCCGCCTGGAGAATGAACATCTGAATAACTGT
GGTGAATTCCGTGCTGTGCGGGACATCTCTGTGGCCCCCCTGAACGCAGATGATCAGACT
CTCCTAGAACAGATGATGGACCAGGATGATGGGGTACGAAACCGCCAGAAGAATCGGTCA
TGGAAGTACAACCAGAGCATATCCCTGCGCCGGCCTCGCCTCGCTTCTCAATCCAAGGCT
CGTGACACTAAGGTATTGATAGAAGACACAGATGATGAAGCTAACACTTGA

# Macromolecular_Interacting_Partner_21_GenBank_ID_Gene:
AF099082

# Macromolecular_Interacting_Partner_21_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_21_Locus:
1q25.1

# Macromolecular_Interacting_Partner_21_SNPs:
rs12078050; rs35706835; rs1061016; rs1061015; rs3856061; rs16856477; rs2027354; rs2271669; rs2944261; rs1339768; rs7544774; rs7556184; rs10914066; rs3856060; rs7516646; rs2331886; rs3843278; rs1980157; rs3856058; rs10737351; rs7542521; rs7541650; rs1533422; rs6425654; rs3013633; rs12120522; rs6686781; rs4652535; rs6677506; rs2138399; rs7536258; rs3789373; rs6661417; rs2176184; rs10914111; rs7522212; rs10914112; rs6425649; rs2944262; rs7527074; rs7556592; rs1554183; rs7548671; rs2176183; rs3002113; rs6685113; rs6692867; rs10914083; rs10914080; rs6693245; rs3908048; rs10494532; rs6677349; rs10914117; rs9425881; rs6700926; rs10914113; rs6703189; rs3002117; rs6692456; rs3856059; rs6425655; rs10914123; rs10914088; rs11808588; rs3002119; rs1554185; rs6677681; rs10798788; rs12075005; rs12089305; rs6659049; rs4652526; rs7517852; rs3897798; rs7553766; rs7525801; rs7549787; rs12064913; rs7545150; rs12073086; rs1400038; rs11810413; rs6698724; rs12075809; rs12733315; rs12088425; rs12096475; rs12059644; rs6689853; rs7522604; rs12725006; rs12071498; rs6664966; rs10914085; rs12079057; rs3903981; rs12068720; rs7555356; rs12070161; rs4550006; rs7513368; rs7548261; rs16856475; rs6672886; rs12404501; rs6671675; rs6693045; rs12142163; rs12402575; rs10798793; rs2271668; rs12087562; rs10914093; rs17373584; rs6425652; rs12401315; rs12095684; rs6694620; rs6682974; rs12401914; rs12566450; rs7349119; rs12059686; rs12565658; rs3789366; rs12069760; rs16856367; rs12064862; rs12734308; rs3002116; rs6425653; rs2331753; rs17301762; rs10914095; rs12088419; rs12076888; rs17373425; rs12081201; rs12082289; rs6676219; rs12079983; rs3789370; rs11585146; rs7514404; rs12091686; rs12067934; rs3845406; rs4083591; rs10914096; rs12093826; rs6691204; rs6682446; rs10914064; rs6425651; rs4652529; rs6688486; rs12086487; rs12084841; rs12143462; rs12073140; rs4439326; rs12084318; rs10914074; rs10914086; rs7546227; rs6681878; rs12409824; rs1970404; rs3789367; rs12070064; rs11585295; rs11579564; rs12087860; rs12080611; rs6425650; rs12088485; rs950830; rs12082250; rs12063893; rs12094326; rs10914077; rs10914087; rs4652533; rs10914084; rs12408176; rs3761904; rs10914107; rs4652531; rs1339769; rs11807408; rs2331626; rs16856420; rs7548318; rs7524547; rs11807424; rs6677570; rs4652536; rs1554184; rs12070595; rs6676373; rs2331887; rs10798794; rs12137673; rs12088430; rs10399718; rs6659262; rs10914081; rs7520377; rs10914098; rs12076875; rs10914076; rs17373501; rs6668578; rs12077610; rs12066422; rs12097114; rs3002123; rs9730482; rs12089474; rs12081846; rs12058871; rs4652534; rs7531674; rs12058106; rs6672129; rs12085097; rs16856374; rs7528848; rs11576584; rs12064145; rs10914115; rs10399804; rs12405265; rs12082726; rs2944259; rs12084517; rs10914092; rs12068624; rs12043745; rs10914122; rs12121436; rs4454505; rs3789369; rs10914079; rs12073289; rs4652527; rs11806523; rs11484677; rs6685653; rs6675596; rs11801890; rs11811353; rs12067061; rs17301405; rs12058064; rs6668077; rs12094045; rs2063849; rs12076671; rs12087173; rs10914062; rs12120797; rs7531753; rs12063811; rs12088182; rs3002118; rs4542178; rs12030506; rs10914075; rs17373660; rs2877438; rs10914116; rs10914067; rs12089155; rs6674734; rs7513630; rs12092463; rs12092799; rs6681220; rs12092594; rs11804145; rs3903979; rs7533512; rs6662788; rs12040430; rs7537396; rs12075181; rs11487432; rs12081764; rs7528955; rs10914078; rs10914120; rs6667050; rs12568410; rs10753223; rs4652528; rs12084966; rs12087411; rs10798792; rs17373411; rs17301936; rs12128940; rs6686881; rs10914063; rs12097111; rs7519125; rs3845407; rs17373383; rs12092161; rs10914089; rs12042617; rs6700702; rs7527018; rs12143915; rs6659121; rs2944260; rs6681637; rs12119247; rs4598454; rs12097202; rs3002114; rs12120511; rs16856391; rs12083109; rs6671456; rs12066936; rs16856409; rs769935; rs12059678; rs10914090; rs12090251; rs7512811; rs12097831; rs10914071; rs11585424; rs9919167; rs7550861; rs10914059; rs12079213; rs12089469; rs1973674; rs16856422; rs7536352; rs12090165; rs12077123; rs6674012; rs4652532; rs12040223; rs12093445; rs7546516; rs4652530; rs12085100; rs7535885; rs17301370; rs12093933; rs6672994; rs9701903; rs16856405; rs12075718; rs10753224; rs10914119; rs6682537; rs11577044; rs6679725; rs6689104; rs12408146; rs3002115; rs7550031; rs10914108; rs12088750; rs12095275; rs6679698; rs12047845; rs12079208; rs10914060; rs12141176; rs10914091; rs11576994; rs7537718; rs7524525; rs11484582; rs4652525; rs12089583; rs12080368; rs1515960; rs12060280; rs11809124; rs7556291; rs6672316; rs12084365; rs17301454; rs10914065; rs12079923; rs12090937; rs12088431; rs12086559; rs6704318; rs17301602; rs12063354; rs9919230; rs6697358; rs12404095; rs7512042; rs12131056; rs12116878; rs16856438; rs6687713; rs12059242; rs6659019; rs6692545; rs12087806; rs12076333; rs2944263; rs17301581; rs12075235; rs12079458; rs6659368; rs6699726; rs12078652; rs16856361; rs12035742; rs12084562; rs12060106; rs6675189; rs10798790; rs10753225; rs6688797; rs7526917; rs7523694; rs13374649; rs3002121; rs12076634; rs10914061; rs3761903; rs10157637; rs4651073; rs6656378; rs3819952; rs3819951; rs4652524; rs4651074; rs4651075; rs1061012; rs34768053; rs1996276; rs1061013; rs1061011; rs41267642; rs12084682; rs35596452; rs1802468; rs41267640; rs1061014; rs12069405; rs12072714; rs35899083; rs10399760; rs12069170; rs35634879; rs12068825; rs7535399; rs6687073; rs12059839; rs34091923; rs34357700; rs1170294; rs12137272; rs35376372; rs35119730; rs6692550; rs6689692; rs35368045; rs6677659; rs12751213; rs12085218; rs12073278; rs12088166; rs12080210; rs12089730; rs35498896; rs36192525; rs7516696; rs12135869; rs3013638; rs34365194; rs9919245; rs12058670; rs12749805; rs34128615; rs35681768; rs12059699; rs11484676; rs12128272; rs34223946; rs12064567; rs769933; rs12756269; rs28816442; rs34418557; rs12032554; rs11445781; rs2877416; rs4265395; rs769932; rs12060769; rs11440037; rs10753222; rs35876811; rs12132252; rs6663487; rs6698414; rs28836308; rs10914072; rs1177639; rs35538297; rs6698667; rs12067633; rs12097443; rs35252691; rs34623001; rs12408817; rs12752375; rs12025874; rs12074901; rs12749776; rs10914106; rs34753711; rs35751561; rs12073959; rs12753167; rs10558534; rs35942449; rs36079789; rs28881298; rs12087837; rs12080481; rs28860229; rs28833548; rs10914114; rs35380232; rs34039618; rs12079485; rs12060542; rs34452902; rs35645548; rs5779071; rs10914094; rs35141455; rs3013634; rs4589068; rs10914102; rs10546837; rs769938; rs12091297; rs12751381; rs35614018; rs33993562; rs35730132; rs36070137; rs10581508; rs35061881; rs12737645; rs10798787; rs35878742; rs35166039; rs12082519; rs12063649; rs10914099; rs12031055; rs2877483; rs1170295; rs35110365; rs13375645; rs36028996; rs12072401; rs12751387; rs12064405; rs769934; rs3856057; rs35189351; rs35845410; rs28772709; rs10914105; rs12240174; rs34558880; rs12080816; rs34441510; rs12086875; rs3013637; rs35110124; rs28565993; rs6675123; rs10914104; rs6662212; rs12065070; rs7533479; rs12135573; rs7530180; rs28666703; rs11449953; rs28782566; rs34815509; rs11324246; rs6663785; rs12060548; rs12161381; rs35556631; rs12116876; rs12749777; rs12129087; rs10914121; rs7512167; rs12065537; rs35998839; rs12128212; rs13373853; rs34479247; rs6670907; rs12076345; rs12568601; rs35968683; rs34120085; rs12064761; rs12069166; rs11487340; rs35243968; rs10914101; rs36167773; rs12071329; rs35444116; rs12085217; rs769939; rs34129623; rs4108558; rs12072020; rs4259606; rs12029102; rs35877384; rs12161380; rs12028357; rs33968119; rs10914068; rs12062549; rs12097661; rs11405062; rs12041228; rs10914103; rs12080899; rs12076809; rs7548808; rs12066418; rs28568336; rs12405314; rs12740838; rs6667095; rs12060123; rs12089522; rs34643742; rs35152584; rs11585334; rs28408114; rs9661675; rs12750203; rs6688066; rs35468372; rs34533089; rs34620815; rs7550955; rs796362; rs3002120; rs6658939; rs12070554; rs35865365; rs5779073; rs10914082; rs34451113; rs35230355; rs34984251; rs12041304; rs34557405; rs35142932; rs34131531; rs28396858; rs4451517; rs12038722; rs11274029; rs12062205; rs10715397; rs11326223; rs34627089; rs10651092; rs28850620; rs36038671; rs34045279; rs12063306; rs11418311; rs2138400; rs35827633; rs6700142; rs35280558; rs10914069; rs12088071; rs12036267; rs12086949; rs10690260; rs9660136; rs35176660; rs12403017; rs35378716; rs3013636; rs35422661; rs34000665; rs12068419; rs28629326; rs34364797; rs6682227; rs35162664; rs35073990; rs35510210; rs1170293; rs12030483; rs35121491; rs6683906; rs36124473; rs12240182; rs28825378; rs7512166; rs35681731; rs6675116; rs34194019; rs28415771; rs6671138; rs769937; rs12082309; rs34802503; rs769936; rs12755553; rs10583647; rs35051169; rs34655359; rs3002122; rs35823570; rs11423546; rs5779072; rs34710814; rs11419210; rs34238308; rs10914109; rs12759936; rs35290163; rs10689909; rs35952980; rs34084886; rs11382033; rs36037963; rs35789076; rs35649788; rs35119795; rs12146032; rs28830222; rs35597679; rs7513282; rs11285692; rs34791725; rs12060544; rs12750514; rs12076958; rs812178; rs35729459; rs7519345; rs1183955; rs10914070; rs34111145; rs4048715; rs12730801; rs35135601; rs1177638; rs12069169; rs1538635; rs7520151; rs35959005; rs34634655; rs12076029; rs12095957; rs12086744; rs12082348; rs34891099; rs35864013; rs12567731; rs12063974; rs6657287; rs12093183; rs9919331; rs34337796; rs12088908; rs12128218; rs35877382; rs10602658; rs10914110; rs10399869; rs12137133; rs4326588; rs10914097; rs12755563; rs10914100; rs12090598; rs35604689; rs3838270; rs12087750; rs12040252; rs28749898; rs12238979; rs6671987; rs36125676; rs2271667; rs3013635; rs12142014; rs35651171; rs10798789; rs35283288; rs36040726; rs34386449; rs11487433; rs35541887; rs10914073; rs12062543; rs12722943; rs34794644; rs11428923; rs28556586; rs3819953; rs34882362; rs10157839; rs10158909; rs1043069; rs10494535; rs10914054; rs10914055; rs10914057; rs12046212; rs12048384; rs12088793; rs12089778; rs12090821; rs12092920; rs12093156; rs12096142; rs12118646; rs12140490; rs12143674; rs12735695; rs12759582; rs16856482; rs17302040; rs17302054; rs17302075; rs2331899; rs3789368; rs3842895; rs3908502; rs4319285; rs6661325; rs6698961; rs7355147

# Macromolecular_Interacting_Partner_21_General_References:
9990033

# Macromolecular_Interacting_Partner_21_References:
16936198; 16943421; 16973241; 17033282

# Macromolecular_Interacting_Partner_22_ID:
8081

# Macromolecular_Interacting_Partner_22_Name:
Leptin precursor

# Macromolecular_Interacting_Partner_22_Synonyms:
Obesity factor; Obese protein

# Macromolecular_Interacting_Partner_22_Gene_Name:
LEP

# Macromolecular_Interacting_Partner_22_Protein_Sequence:
>Leptin precursor
MHWGTLCGFLWLWPYLFYVQAVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGL
DFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLP
WASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC

# Macromolecular_Interacting_Partner_22_Number_of_Residues:
167

# Macromolecular_Interacting_Partner_22_Molecular_Weight:
18641

# Macromolecular_Interacting_Partner_22_Theoretical_pI:
6.34

# Macromolecular_Interacting_Partner_22_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_22_General_Function:
Not Available

# Macromolecular_Interacting_Partner_22_Specific_Function:
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass

# Macromolecular_Interacting_Partner_22_Pathway:
Not Available

# Macromolecular_Interacting_Partner_22_Reaction:
Not Available

# Macromolecular_Interacting_Partner_22_Pfam_Domain_Function:
PF02024:Leptin

# Macromolecular_Interacting_Partner_22_Signals:
1-21

# Macromolecular_Interacting_Partner_22_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_22_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_22_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_22_GenBank_ID_Protein:
623332

# Macromolecular_Interacting_Partner_22_SwissProt_ID:
LEP_HUMAN (P41159)

# Macromolecular_Interacting_Partner_22_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_22_Genecard_id:
LEP

# Macromolecular_Interacting_Partner_22_Geneatlas_id:
LEP

# Macromolecular_Interacting_Partner_22_hgnc_id:
HGNC:6553

# Macromolecular_Interacting_Partner_22_PDB_ID:
1AX8

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_22_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_22_Gene_Sequence:
>504 bp
ATGCATTGGGGAACCCTGTGCGGATTCTTGTGGCTTTGGCCCTATCTTTTCTATGTCCAA
GCTGTGCCCATCCAAAAAGTCCAAGATGACACCAAAACCCTCATCAAGACAATTGTCACC
AGGATCAATGACATTTCACACACGCAGTCAGTCTCCTCCAAACAGAAAGTCACCGGTTTG
GACTTCATTCCTGGGCTCCACCCCATCCTGACCTTATCCAAGATGGACCAGACACTGGCA
GTCTACCAACAGATCCTCACCAGTATGCCTTCCAGAAACGTGATCCAAATATCCAACGAC
CTGGAGAACCTCCGGGATCTTCTTCACGTGCTGGCCTTCTCTAAGAGCTGCCACTTGCCC
TGGGCCAGTGGCCTGGAGACCTTGGACAGCCTGGGGGGTGTCCTGGAAGCTTCAGGCTAC
TCCACAGAGGTGGTGGCCCTGAGCAGGCTGCAGGGGTCTCTGCAGGACATGCTGTGGCAG
CTGGACCTCAGCCCTGGGTGCTGA

# Macromolecular_Interacting_Partner_22_GenBank_ID_Gene:
U18915

# Macromolecular_Interacting_Partner_22_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_22_Locus:
7q31.3

# Macromolecular_Interacting_Partner_22_SNPs:
rs17151919; rs13306517; rs28954113; rs11763517; rs4731426; rs10954173; rs11761556; rs4731427; rs2167270; rs7791621; rs10257175; rs12706832; rs11760956; rs7795794; rs28954116; rs11978419; rs10244329; rs17151922; rs2278814; rs28959471; rs10954174; rs4236625; rs7796202; rs28954117; rs28959470; rs28954095; rs28954101; rs28954086; rs28954099; rs28959468; rs3750034; rs28954093; rs2278815; rs2122627; rs28954379; rs28959474; rs28954082; rs41457646; rs28954114; rs28954096; rs28959476; rs28954084; rs28954102; rs28954100; rs2060713; rs28954090; rs28954098; rs28954105; rs28954118; rs11980266; rs28954091; rs12706831; rs28959475; rs28954094; rs28954083; rs28756049; rs11973652; rs3793162; rs17151913; rs17151914; rs6956510; rs2071045; rs3828942; rs7788818; rs10264361; rs28954109; rs28954110; rs28954108; rs28954111; rs791616; rs28954376; rs28954081; rs6976701; rs10262600; rs28954369; rs28954080; rs28954371; rs34104384; rs4728096; rs791620; rs28954372; rs28954373; rs28954375; rs35048003; rs28959478; rs10258300; rs12536535; rs28954378; rs13228377; rs1800564; rs1800583; rs28954097; rs11380467; rs35394014; rs28959469; rs10676401; rs28954106; rs1031340; rs28954115; rs1349398; rs34219283; rs28959472; rs28954088; rs10243710; rs6966536; rs28954104; rs10620014; rs34457895; rs13306516; rs33910507; rs28954107; rs41526944; rs41434248; rs28954087; rs34728887; rs28954103; rs28959473; rs41528456; rs17617757; rs28954089; rs28954092; rs34052732; rs10277407; rs28954112; rs41474844; rs13306518; rs35447711; rs34046133; rs36212573; rs28959477; rs36219262; rs791618; rs28954370; rs791619; rs34669250; rs10598051; rs28954377; rs36219261; rs28391558; rs791617; rs28954374; rs36219260; rs10249476; rs10264838; rs10276311; rs10487506; rs10954175; rs10954176; rs11770725; rs12535708; rs12535747; rs12537573; rs13245201; rs1349419; rs1376268; rs16871960; rs17151895; rs2060715; rs2167271; rs35854831; rs4731423; rs4731424; rs4731428; rs4731429; rs4731430; rs6949498; rs712722; rs7778154; rs7782257; rs7798338; rs7799039; rs7801674; rs7802530; rs791604; rs791606; rs791607; rs791608; rs791610; rs791611; rs791612; rs791613; rs791614; rs791615

# Macromolecular_Interacting_Partner_22_General_References:
7984236; 7789654; 8626726; 7499240; 8621021; 10428856; 9166907; 9144295; 9500540

# Macromolecular_Interacting_Partner_22_References:
16955393; 17028445; 17049599

# Macromolecular_Interacting_Partner_23_ID:
7982

# Macromolecular_Interacting_Partner_23_Name:
ATP-binding cassette sub-family G member 1

# Macromolecular_Interacting_Partner_23_Synonyms:
White protein homolog; ATP-binding cassette transporter 8

# Macromolecular_Interacting_Partner_23_Gene_Name:
ABCG1

# Macromolecular_Interacting_Partner_23_Protein_Sequence:
>ATPbinding cassette subfamily G member 1
MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNL
TEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPS
GAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMV
SAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFF
DEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGK
VCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGD
AEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDS
VLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLE
MGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAAL
GTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYIS
YVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFI
SLRLIAYFVLRYKIRAER

# Macromolecular_Interacting_Partner_23_Number_of_Residues:
678

# Macromolecular_Interacting_Partner_23_Molecular_Weight:
75593

# Macromolecular_Interacting_Partner_23_Theoretical_pI:
7.87

# Macromolecular_Interacting_Partner_23_GO_Classification:
>>>
Function:  transporter activity
Function:  permease activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_23_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_23_Specific_Function:
Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages

# Macromolecular_Interacting_Partner_23_Pathway:
Not Available

# Macromolecular_Interacting_Partner_23_Reaction:
Not Available

# Macromolecular_Interacting_Partner_23_Pfam_Domain_Function:
PF01061:ABC2_membrane;
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_23_Signals:
None

# Macromolecular_Interacting_Partner_23_Transmembrane_Regions:
427-445
457-477
507-525
534-555
568-586
650-669

# Macromolecular_Interacting_Partner_23_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_23_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_23_GenBank_ID_Protein:
1160186

# Macromolecular_Interacting_Partner_23_SwissProt_ID:
ABCG1_HUMAN (P45844)

# Macromolecular_Interacting_Partner_23_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_23_Genecard_id:
ABCG1

# Macromolecular_Interacting_Partner_23_Geneatlas_id:
ABCG1

# Macromolecular_Interacting_Partner_23_hgnc_id:
HGNC:73

# Macromolecular_Interacting_Partner_23_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_23_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein. Golgi apparatus; Golgi apparatus membrane; multi-pass membrane protein. Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes

# Macromolecular_Interacting_Partner_23_Gene_Sequence:
>2025 bp
ATGGCCGCTTTCTCGGTCGGCACCGCCATGAATGCCAGCAGTTACTCTGCAGAGATGACG
GAGCCCAAGTCGGTGTGTGTCTCGGTGGATGAGGTGGTGTCCAGCAACATGGAGGCCACT
GAGACGGACCTGCTGAATGGACATCTGAAAAAAGTAGATAATAACCTCACGGAAGCCCAG
CGCTTCTCCTCCTTGCCTCGGAGGGCAGCTGTGAACATTGAATTCAGGGACCTTTCCTAT
TCGGTTCCTGAAGGACCCTGGTGGAGGAAGAAAGGATACAAGACCCTCCTGAAAGGAATT
TCCGGGAAGTTCAATAGTGGTGAGTTGGTGGCCATTATGGGTCCTTCCGGGGCCGGGAAG
TCCACGCTGATGAACATCCTGGCTGGATACAGGGAGACGGGCATGAAGGGGGCCGTCCTC
ATCAACGGCCTGCCCCGGGACCTGCGCTGCTTCCGGAAGGTGTCCTGCTACATCATGCAG
GATGACATGCTGCTGCCGCATCTCACTGTGCAGGAGGCCATGATGGTGTCGGCACATCTG
AAGCTTCAGGAGAAGGATGAAGGCAGAAGGGAAATGGTCAAGGAGATACTGACAGCGCTG
GGCTTGCTGTCTTGCGCCAACACGCGGACCGGGAGCCTGTCAGGTGGTCAGCGCAAGCGC
CTGGCCATCGCGCTGGAGCTGGTGAACAACCCTCCAGTCATGTTCTTCGATGAGCCCACC
AGCGGCCTGGACAGCGCCTCCTGCTTCCAGGTGGTCTCGCTGATGAAAGGGCTCGCTCAA
GGGGGTCGCTCCATCATTTGCACCATCCACCAGCCCAGCGCCAAACTCTTCGAGCTGTTC
GACCAGCTTTACGTCCTGAGTCAAGGACAATGTGTGTACCGGGGAAAAGTCTGCAATCTT
GTGCCATATTTGAGGGATTTGGGTCTGAACTGCCCAACCTACCACAACCCAGCAGATTTT
GTCATGGAGGTTGCATCCGGCGAGTACGGTGATCAGAACAGTCGGCTGGTGAGAGCGGTT
CGGGAGGGCATGTGTGACTCAGACCACAAGAGAGACCTCGGGGGTGATGCCGAGGTGAAC
CCTTTTCTTTGGCACCGCCCCTCTGAAGAGGTAAAGCAGACAAAACGATTAAAGGGGTTG
AGAAAGGACTCCTCGTCCATGGAAGGCTGCCACAGCTTCTCTGCCAGCTGCCTCACGCAG
TTCTGCATCCTCTTCAAGAGGACCTTCCTCAGCATCATGAGGGACTCGGTCCTGACACAC
CTGCGCATCACCTCGCACATTGGGATCGGCCTCCTCATTGGCCTGCTGTACTTGGGGATC
GGGAACGAAACCAAGAAGGTCTTGAGCAACTCCGGCTTCCTCTTCTTCTCCATGCTGTTC
CTCATGTTCGCGGCCCTCATGCCTACTGTTCTGACATTTCCCCTGGAGATGGGAGTCTTT
CTTCGGGAACACCTGAACTACTGGTACAGCCTGAAGGCCTACTACCTGGCCAAGACCATG
GCAGACGTGCCCTTTCAGATCATGTTCCCAGTGGCCTACTGCAGCATCGTGTACTGGATG
ACGTCGCAGCCGTCCGACGCCGTGCGCTTTGTGCTGTTTGCCGCGCTGGGCACCATGACC
TCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGAGCCGCCTCCACGTCCCTGCAGGTG
GCCACTTTCGTGGGCCCAGTGACAGCCATCCCGGTGCTCCTGTTCTCGGGGTTCTTCGTC
AGCTTCGACACCATCCCCACGTACCTACAGTGGATGTCCTACATCTCCTATGTCAGGTAT
GGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTAGACCGGGAAGATCTGCACTGTGAC
ATCGACGAGACGTGCCACTTCCAGAAGTCGGAGGCCATCCTGCGGGAGCTGGACGTGGAA
AATGCCAAGCTGTACCTGGACTTCATCGTACTCGGGATTTTCTTCATCTCCCTCCGCCTC
ATTGCCTATTTGGTCCTCAGGTACAAAATCCGGGCAGAGAGGTAA

# Macromolecular_Interacting_Partner_23_GenBank_ID_Gene:
X91249

# Macromolecular_Interacting_Partner_23_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_23_Locus:
Not Available

# Macromolecular_Interacting_Partner_23_SNPs:
rs915843; rs915842; rs915841; rs4148102; rs4148084; rs4148105; rs8129752; rs8134682; rs692383; rs225412; rs8127716; rs4148086; rs4148106; rs1840593; rs4148085; rs4148107; rs7283103; rs4148101; rs10084554; rs9977571; rs1817200; rs12626951; rs4148087; rs9982034; rs2032259; rs1378575; rs2032260; rs2168344; rs564010; rs1378576; rs8130198; rs225411; rs4148100; rs1044317; rs915845; rs9975740; rs12482369; rs2381040; rs4148090; rs1378574; rs8131563; rs2234715; rs9981390; rs4148103; rs2890566; rs4148083; rs1117640; rs2381038; rs221949; rs9982029; rs7278922; rs2381039; rs4148095; rs9976024; rs2234714; rs4148104; rs10084555; rs12626538; rs11701721; rs4148088; rs12627318; rs1598482; rs1824011; rs7277707; rs2839478; rs425215; rs225398; rs2234719; rs532345; rs225378; rs450808; rs225394; rs225371; rs2839480; rs225401; rs225441; rs11910928; rs225370; rs225447; rs3788002; rs2839481; rs691687; rs3787970; rs3788010; rs4148123; rs225409; rs2234721; rs225443; rs881394; rs2234718; rs9975333; rs8132809; rs914189; rs3787978; rs7280003; rs2839482; rs225448; rs183436; rs225387; rs4148125; rs178744; rs225445; rs225372; rs225393; rs881395; rs225446; rs225410; rs6586298; rs4148137; rs225440; rs3827228; rs4148117; rs2276233; rs225407; rs915847; rs8134674; rs225386; rs8129569; rs225374; rs4920080; rs7279750; rs915846; rs7281345; rs482303; rs7281093; rs225382; rs3787965; rs225406; rs225388; rs6586300; rs3787968; rs7275482; rs3827225; rs17767083; rs225395; rs225444; rs4148139; rs11909889; rs225400; rs225391; rs225381; rs225380; rs8128565; rs170445; rs2276235; rs182694; rs225376; rs2298690; rs3788007; rs225385; rs225399; rs225403; rs6586301; rs492338; rs413650; rs225405; rs6586299; rs7277991; rs4148124; rs3787966; rs2298689; rs225379; rs3787986; rs17114631; rs225408; rs225383; rs4148133; rs225396; rs225402; rs413656; rs225449; rs3787972; rs178743; rs9982242; rs3787997; rs12627548; rs17114583; rs11702801; rs7283699; rs225413; rs9976804; rs3787985; rs8134787; rs74757; rs17114590; rs3788001; rs225390; rs8134486; rs3788009; rs4148118; rs9980952; rs8127340; rs3787971; rs4148122; rs4148111; rs12329683; rs3788006; rs3787994; rs184433; rs10788646; rs4148114; rs9974658; rs4148135; rs225377; rs13052462; rs1311800; rs17114581; rs9978842; rs474142; rs3787967; rs3787995; rs13050646; rs11700907; rs225373; rs461129; rs441626; rs4920077; rs3827227; rs4148134; rs225392; rs3787979; rs9984462; rs9978671; rs9982196; rs170436; rs9974417; rs4920081; rs12483381; rs17114591; rs4148120; rs17114604; rs8126601; rs8130374; rs3788005; rs9653812; rs225384; rs225375; rs9975218; rs427716; rs3788000; rs551928; rs1893590; rs1378577; rs9325632; rs4148082; rs12626718; rs7281320; rs35141461; rs7281684; rs8131089; rs28519543; rs8130893; rs4920072; rs28494082; rs35282280; rs13047540; rs1824010; rs4148093; rs4148098; rs9975490; rs34786983; rs4919978; rs8126971; rs28760964; rs221948; rs692369; rs6147522; rs13046865; rs11367330; rs28435557; rs34068794; rs13051040; rs35328038; rs1893591; rs4148091; rs8134346; rs35840150; rs34118939; rs4148092; rs13051078; rs4148099; rs7281377; rs34140987; rs4148089; rs8134684; rs4148143; rs35291846; rs9975154; rs35925967; rs11372946; rs8129302; rs436368; rs13048493; rs4327312; rs34880593; rs11271747; rs8131925; rs13051166; rs34116920; rs3746913; rs34146976; rs4148094; rs4148144; rs35946579; rs34384834; rs28476477; rs35447696; rs12106329; rs7275664; rs11700802; rs13047412; rs8130516; rs13052527; rs9979687; rs3787981; rs3788008; rs4148109; rs1312077; rs8132611; rs4148110; rs7281676; rs4920079; rs498754; rs34794634; rs4919982; rs4148126; rs34349454; rs35478444; rs34234921; rs1797424; rs35873421; rs9982016; rs35280343; rs3827224; rs36033318; rs7280035; rs8130228; rs7278062; rs9975632; rs8130657; rs3787964; rs4148113; rs35436100; rs35477367; rs36054436; rs3787996; rs34768841; rs8127035; rs34578735; rs2234720; rs11411618; rs35863961; rs35519182; rs4148130; rs4148136; rs9977145; rs3787976; rs1036803; rs8133920; rs11330762; rs35325051; rs170444; rs36031456; rs4148115; rs7278222; rs3787982; rs8131852; rs225442; rs28463023; rs4148127; rs4919981; rs9979602; rs11701894; rs9984192; rs4919980; rs10541277; rs9982284; rs13049646; rs9979677; rs28731398; rs9974993; rs34585398; rs8128750; rs10665577; rs28510925; rs3787999; rs35948230; rs34520302; rs10675134; rs35522463; rs9979482; rs9983344; rs170440; rs34933653; rs35823612; rs35276014; rs1126222; rs35000523; rs4148119; rs170439; rs170441; rs8134199; rs10590039; rs7283123; rs4148128; rs35875847; rs170437; rs9978294; rs2000763; rs34030542; rs11911691; rs11402831; rs28701778; rs551970; rs3842456; rs12627529; rs4148132; rs1036804; rs3788003; rs11330761; rs4148112; rs35899486; rs8132392; rs1311799; rs35004862; rs1312076; rs4148147; rs34756314; rs34994549; rs35921043; rs28675969; rs35168988; rs4148138; rs2234717; rs11701502; rs2849720; rs1311798; rs35533965; rs9979594; rs3787987; rs34256469; rs4920075; rs3787980; rs3787984; rs35942249; rs7283570; rs9979676; rs7280114; rs4148129; rs10523936; rs33947634; rs225397; rs36078877; rs170438; rs8134263; rs28377560; rs10656512; rs1311801; rs35215336; rs36013117; rs4148131; rs8132393; rs9978287; rs35972398; rs35066189; rs8130349; rs34761716; rs172826; rs9979589; rs11277234; rs4148141; rs2276234; rs8133786; rs10592727; rs9979980; rs10550045; rs731663; rs692547; rs7279161; rs3787977; rs35140177; rs4148116; rs35777749; rs225404; rs4148121; rs33951854; rs28686779; rs4148108; rs36039103; rs691545; rs9976437; rs35927717; rs11701788; rs11908805; rs11910365; rs11910395; rs11911417; rs13049710; rs13053126; rs1541290; rs15661; rs17114504; rs1893589; rs221950; rs225434; rs225435; rs2381037; rs2839477; rs2839483; rs2839484; rs2839485; rs35803624; rs3746915; rs3746916; rs3746917; rs449087; rs4547619; rs6586304; rs6586305; rs6586306; rs6586307; rs7276176; rs7277545; rs7279654; rs7281065; rs7281551; rs7283700; rs748318; rs748319; rs748320; rs750817; rs750818; rs8126796; rs8128237; rs8128478; rs8129519; rs8129532; rs8131660; rs915844; rs9984673

# Macromolecular_Interacting_Partner_23_General_References:
8659545; 10830953; 10950923; 11279031; 11162488; 11500512; 9034316; 10799558; 10639163; 12032171; 11590207

# Macromolecular_Interacting_Partner_23_References:
16971496; 17082211; 17088262

# Macromolecular_Interacting_Partner_24_ID:
8340

# Macromolecular_Interacting_Partner_24_Name:
Caveolin-1

# Macromolecular_Interacting_Partner_24_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_24_Gene_Name:
CAV1

# Macromolecular_Interacting_Partner_24_Protein_Sequence:
>Caveolin1
MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADELSEKQVYDAHTKEIDLVNRDPKHLN
DDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFA
ILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTVCDPLFEAVGKIFSNVRINLQKEI

# Macromolecular_Interacting_Partner_24_Number_of_Residues:
178

# Macromolecular_Interacting_Partner_24_Molecular_Weight:
20472

# Macromolecular_Interacting_Partner_24_Theoretical_pI:
5.93

# Macromolecular_Interacting_Partner_24_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane
Component:  plasma membrane
Component:  caveola
Component:  caveolar membrane

# Macromolecular_Interacting_Partner_24_General_Function:
Not Available

# Macromolecular_Interacting_Partner_24_Specific_Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity

# Macromolecular_Interacting_Partner_24_Pathway:
Not Available

# Macromolecular_Interacting_Partner_24_Reaction:
Not Available

# Macromolecular_Interacting_Partner_24_Pfam_Domain_Function:
PF01146:Caveolin

# Macromolecular_Interacting_Partner_24_Signals:
None

# Macromolecular_Interacting_Partner_24_Transmembrane_Regions:
105-125

# Macromolecular_Interacting_Partner_24_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_24_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_24_GenBank_ID_Protein:
38516

# Macromolecular_Interacting_Partner_24_SwissProt_ID:
CAV1_HUMAN (Q03135)

# Macromolecular_Interacting_Partner_24_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_24_Genecard_id:
CAV1

# Macromolecular_Interacting_Partner_24_Geneatlas_id:
CAV1

# Macromolecular_Interacting_Partner_24_hgnc_id:
HGNC:1527

# Macromolecular_Interacting_Partner_24_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_24_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; peripheral membrane protein; cytoplasmic side. Cell membrane; caveola; peripheral membrane protein; cytoplasmic side. Note=Membrane protein of caveolae. Potential hairpin-like structure in the membrane

# Macromolecular_Interacting_Partner_24_Gene_Sequence:
>537 bp
ATGTCTGGGGGCAAATACGTAGACTCGGAGGGACATCTCTACACCGTTCCCATCCGGGAA
CAGGGCAACATCTACAAGCCCAACAACAAGGCCATGGCAGACGAGCTGAGCGAGAAGCAA
GTGTACGACGCGCACACCAAGGAGATCGACCTGGTCAACCGCGACCCTAAACACCTCAAC
GATGACGTGGTCAAGATTGACTTTGAAGATGTGATTGCAGAACCAGAAGGGACACACAGT
TTTCACGGCATTTGGAAGGCCAGCTTCACCACCTTCACTGTGACGAAATACTGGTTTTAC
CGCTTGCTGTCTGCCCTCTTTGGCATCCCGATGGCACTCATCTGGGGCATTTACTTCGCC
ATTCTCTCTTTCCTGCACATCTGGGCAGTTGTACCATGCATTAAGAGCTTCCTGATTGAG
ATTCAGTGCACCAGCCGTGTCTATTCCATCTACGTCCACACCGTCTGTGACCCACTCTTT
GAAGCTGTTGGGAAAATATTCAGCAATGTCCGCATCAACTTGCAGAAAGAAATATAA

# Macromolecular_Interacting_Partner_24_GenBank_ID_Gene:
Z18951

# Macromolecular_Interacting_Partner_24_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_24_Locus:
7q31.1

# Macromolecular_Interacting_Partner_24_SNPs:
rs33972549; rs35242077; rs1049337; rs1049314; rs1049334; rs8713; rs35617054; rs6867; rs34397467; rs35386406; rs34709923; rs9920; rs34585220; rs35273517; rs34123906; rs729949; rs1543293; rs1022436; rs6466587; rs9886215; rs2109516; rs4730751; rs3757732; rs3807994; rs3807992; rs10256914; rs7789117; rs3757733; rs6466583; rs3807995; rs6466586; rs1997572; rs9885998; rs3779512; rs3801995; rs3807988; rs926198; rs959173; rs3807987; rs7804372; rs3807990; rs6466585; rs917664; rs10240619; rs6466584; rs3801993; rs1997623; rs4730748; rs3815412; rs3807986; rs12672038; rs10270569; rs2742125; rs12668226; rs2052105; rs9886219; rs11773845; rs3807989; rs9649394; rs1474510; rs6466588; rs3801994; rs9886216; rs7791631; rs10246396; rs10953822; rs4730749; rs34592877; rs17588703; rs4730750; rs1997571; rs13233553; rs6961881; rs1476833; rs11973363; rs11979788; rs7778733; rs3779514; rs35697540; rs17160353; rs6977359; rs976739; rs11978747; rs35182456; rs12540549; rs12669209; rs926199; rs926200; rs3779513; rs6955882; rs2215448; rs35103261; rs6466582; rs34915824; rs2215449; rs6466581; rs4320488; rs34552012; rs35308471; rs1049375; rs35901258; rs41309216; rs6957212; rs11553391; rs36068092; rs11553390; rs11553395; rs10237996; rs6868; rs7789052; rs11977814; rs6961876; rs34287272; rs2742128; rs35631004; rs36175575; rs3807984; rs3839825; rs35534382; rs11980788; rs11973393; rs35902398; rs3807991; rs10525629; rs35056305; rs34685461; rs28428476; rs5886830; rs34678019; rs34534891; rs36050167; rs13245706; rs35771918; rs2302388; rs2742127; rs13245397; rs13243017; rs34654199; rs35409784; rs33913297; rs13232830; rs34680426; rs11423839; rs35527092; rs6961694; rs6961021; rs13307784; rs6961879; rs28640050; rs2535214; rs35801452; rs13232825; rs3807993; rs35047973; rs34806326; rs34066083; rs4727834; rs13245413; rs34974250; rs13245689; rs10280584; rs6943876; rs1474511; rs2742126; rs10241283; rs34938433; rs10248474; rs35646544; rs3807985; rs10262090; rs11292498; rs10672081; rs35532793; rs10267338; rs34163793; rs976740; rs13242816; rs34400890; rs34773204; rs35141724; rs35500345; rs6975442; rs7458849; rs10570289; rs35467920; rs2535213; rs34587231; rs6950593; rs5886828; rs36224419; rs36224420; rs4385407; rs10570290; rs10227696; rs10232369; rs10250683; rs10257125; rs10258188; rs10273326; rs10280730; rs11974088; rs11979486; rs12540035; rs13224179; rs17138812; rs1860588; rs2052106; rs2109514; rs2109515; rs2159581; rs2535210; rs2535211; rs2535212; rs34936262; rs4236601; rs4730745; rs6959106; rs6961388; rs6976011; rs7795510; rs7802124; rs7802438; rs975028; rs9918538

# Macromolecular_Interacting_Partner_24_General_References:
1360410; 10086342; 10218480; 12368209

# Macromolecular_Interacting_Partner_24_References:
17121865; 17141202

# Macromolecular_Interacting_Partner_25_ID:
7848

# Macromolecular_Interacting_Partner_25_Name:
Peroxisome proliferator-activated receptor delta

# Macromolecular_Interacting_Partner_25_Synonyms:
PPAR-delta; PPAR- beta; Nuclear hormone receptor 1; NUC1; NUCI

# Macromolecular_Interacting_Partner_25_Gene_Name:
PPARD

# Macromolecular_Interacting_Partner_25_Protein_Sequence:
>Peroxisome proliferatoractivated receptor delta
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM
GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK
NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK
HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE
ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK
DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGD
RPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI
KKTETETSLHPLLQEIYKDMY

# Macromolecular_Interacting_Partner_25_Number_of_Residues:
441

# Macromolecular_Interacting_Partner_25_Molecular_Weight:
49904

# Macromolecular_Interacting_Partner_25_Theoretical_pI:
7.65

# Macromolecular_Interacting_Partner_25_GO_Classification:
>>>
Function:  steroid hormone receptor activity
Function:  transcription factor activity
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_25_General_Function:
Not Available

# Macromolecular_Interacting_Partner_25_Specific_Function:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Decreases expression of NPC1L1 once activated by a ligand

# Macromolecular_Interacting_Partner_25_Pathway:
Not Available

# Macromolecular_Interacting_Partner_25_Reaction:
Not Available

# Macromolecular_Interacting_Partner_25_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_25_Signals:
None

# Macromolecular_Interacting_Partner_25_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_25_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_25_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_25_GenBank_ID_Protein:
190230

# Macromolecular_Interacting_Partner_25_SwissProt_ID:
PPARD_HUMAN (Q03181)

# Macromolecular_Interacting_Partner_25_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_25_Genecard_id:
PPARD

# Macromolecular_Interacting_Partner_25_Geneatlas_id:
PPARD

# Macromolecular_Interacting_Partner_25_hgnc_id:
HGNC:9235

# Macromolecular_Interacting_Partner_25_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_25_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_25_Gene_Sequence:
>1326 bp
ATGGAGCAGCCACAGGAGGAAGCCCCTGAGGTCCGGGAAGAGGAGGAGAAAGAGGAAGTG
GCAGAGGCAGAAGGAGCCCCAGAGCTCAATGGGGGACCACAGCATGCACTTCCTTCCAGC
AGCTACACAGACCTCTCCCGGAGCTCCTCGCCACCCTCACTGCTGGACCAACTGCAGATG
GGCTGTGACGGGGCCTCATGCGGCAGCCTCAACATGGAGTGCCGGGTGTGCGGGGACAAG
GCATCGGGCTTCCACTACGGTGTTCATGCATGTGAGGGGTGCAAGGGCTTCTTCCGTCGT
ACGATCCGCATGAAGCTGGAGTACGAGAAGTGTGAGCGCAGCTGCAAGATTCAGAAGAAG
AACCGCAACAAGTGCCAGTACTGCCGCTTCCAGAAGTGCCTGGCACTGGGCATGTCACAC
AACGCTATCCGTTTTGGTCGGATGCCGGAGGCTGAGAAGAGGAAGCTGGTGGCAGGGCTG
ACTGCAAACGAGGGGAGCCAGTACAACCCACAGGTGGCCGACCTGAAGGCCTTCTCCAAG
CACATCTACAATGCCTACCTGAAAAACTTCAACATGACCAAAAAGAAGGCCCGCAGCATC
CTCACCGGCAAAGCCAGCCACACGGCGCCCTTTGTGATCCACGACATCGAGACATTGTGG
CAGGCAGAGAAGGGGCTGGTGTGGAAGCAGTTGGTGAATGGCCTGCCTCCCTACAAGGAG
ATCAGCGTGCACGTCTTCTACCGCTGCCAGTGCACCACAGTGGAGACCGTGCGGGAGCTC
ACTGAGTTCGCCAAGAGCATCCCCAGCTTCAGCAGCCTCTTCCTCAACGACCAGGTTACC
CTTCTCAAGTATGGCGTGCACGAGGCCATCTTCGCCATGCTGGCCTCTATCGTCAACAAG
GACGGGCTGCTGGTAGCCAACGGCAGTGGCTTTGTCACCCGTGAGTTCCTGCGCAGCCTC
CGCAAACCCTTCAGTGATATCATTGAGCCTAAGTTTGAATTTGCTGTCAAGTTCAACGCC
CTGGAACTTGATGACAGTGACCTGGCCCTATTCATTGCGGCCATCATTCTGTGTGGAGAC
CGGCCAGGCCTCATGAACGTTCCACGGGTGGAGGCTATCCAGGACACCATCCTGCGTGCC
CTCGAATTCCACCTGCAGGCCAACCACCCTGATGCCCAGTACCTCTTCCCCAAGCTGCTG
CAGAAGATGGCTGACCTGCGGCAACTGGTCACCGAGCACGCCCAGATGATGCAGCGGATC
AAGAAGACCGAAACCGAGACCTCGCTGCACCCTCTGCTCCAGGAGATCTACAAGGACATG
TACTAA

# Macromolecular_Interacting_Partner_25_GenBank_ID_Gene:
L07592

# Macromolecular_Interacting_Partner_25_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_25_Locus:
6p21.2-p21.1

# Macromolecular_Interacting_Partner_25_SNPs:
Not Available

# Macromolecular_Interacting_Partner_25_General_References:
1333051; 10851270; 14574404

# Macromolecular_Interacting_Partner_25_References:
17110604

# Macromolecular_Interacting_Partner_26_ID:
8422

# Macromolecular_Interacting_Partner_26_Name:
Sterol regulatory element-binding protein 2

# Macromolecular_Interacting_Partner_26_Synonyms:
SREBP-2; Sterol regulatory element-binding transcription factor 2

# Macromolecular_Interacting_Partner_26_Gene_Name:
SREBF2

# Macromolecular_Interacting_Partner_26_Protein_Sequence:
>Sterol regulatory elementbinding protein 2
MDDSGELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFPDLFSEQLCSSFPGSGGS
GSSSGSSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSFSPSAASPQAPTLQVKVSPTS
VPTTPRATPILQPRPQPQPQPQTQLQQQTVMITPTFSTTPQTRIIQQPLIYQNAATSFQV
LQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVAAPQVQQVP
VLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILT
TMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGT
DAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDNEVDLK
IEDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRS
RILLCVLTFLCLSFNPLTSLLQWGGAHDSDQHPHSGSGRSVLSFESGSGGWFDWMMPTLL
LWLVNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLARGDFAAAAGNLQTC
LAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQCRRATPATEAGFEDEAK
TSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTA
AMGLKTRCGGKLGFLASYFLSRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSVKSA
AKESLYCAQRNPADPIAQVHQAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEY
LKLLHSFVDSVGVMSPPLSRSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFT
KVERIPKALEVTESPLVKAIFHACRAMHASLPGKADGQQSSFCHCERASGHLWSSLNVSG
ATSDPALNHVVQLLTCDLLLSLRTALWQKQASASQAVGETYHASGAELAGFQRDLGSLRR
LAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRER
ATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCNDCQQMIVKLGGGTAIAA
S

# Macromolecular_Interacting_Partner_26_Number_of_Residues:
1141

# Macromolecular_Interacting_Partner_26_Molecular_Weight:
123689

# Macromolecular_Interacting_Partner_26_Theoretical_pI:
8.49

# Macromolecular_Interacting_Partner_26_GO_Classification:
>>>
Function:  transcription regulator activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_26_General_Function:
Not Available

# Macromolecular_Interacting_Partner_26_Specific_Function:
Transcriptional activator that binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes

# Macromolecular_Interacting_Partner_26_Pathway:
Not Available

# Macromolecular_Interacting_Partner_26_Reaction:
Not Available

# Macromolecular_Interacting_Partner_26_Pfam_Domain_Function:
PF00010:HLH

# Macromolecular_Interacting_Partner_26_Signals:
None

# Macromolecular_Interacting_Partner_26_Transmembrane_Regions:
480-500
534-554

# Macromolecular_Interacting_Partner_26_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_26_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_26_GenBank_ID_Protein:
451330

# Macromolecular_Interacting_Partner_26_SwissProt_ID:
SRBP2_HUMAN (Q12772)

# Macromolecular_Interacting_Partner_26_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_26_Genecard_id:
SREBF2

# Macromolecular_Interacting_Partner_26_Geneatlas_id:
SREBF2

# Macromolecular_Interacting_Partner_26_hgnc_id:
HGNC:11290

# Macromolecular_Interacting_Partner_26_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_26_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein. Golgi apparatus; Golgi apparatus membrane; multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols

# Macromolecular_Interacting_Partner_26_Gene_Sequence:
>3426 bp
ATGGACGACAGCGGCGAGCTGGGTGGTCTGGAGACCATGGAGACCCTCACGGAGCTGGGC
GACGAGCTGACCCTGGGAGACATCGACGAGATGCTGCAATTTGTCAGTAATCAAGTGGGA
GAGTTCCCTGACTTGTTTTCAGAACAGCTGTGTAGCTCCTTTCCTGGCAGTGGTGGTAGT
GGTAGCAGCAGCGGCAGCAGTGGCAGCAGCAGCAGCAGCAGCAATGGCAGGGGCAGCAGC
AGCGGAGCTGTGGACCCTTCAGTGCAACGGTCATTCACCCAGGTCACATTACCTTCCTTC
TCTCCCTCGGCGGCCTCCCCACAGGCTCCAACTCTGCAAGTCAAGGTTTCTCCCACCTCA
GTTCCCACCACACCCAGGGCAACTCCTATTCTTCAGCCCCGCCCCCAGCCCCAGCCTCAA
CCTCAAACTCAGCTGCAACAACAGACGGTAATGATCACGCCAACATTCAGCACCACTCCG
CAGACGAGGATCATCCAGCAGCCTTTGATATACCAGAATGCAGCTACTAGCTTTCAAGTC
CTTCAGCCTCAAGTCCAAAGCCTGGTGACATCCTCCCAGGTACAGCCGGTCACCATTCAG
CAGCAGGTGCAGACAGTACAGGCCCAGCGGGTGCTGACACAAACGGCCAATGGCACGCTG
CAGACCCTTGCCCCGGCTACGGTGCAGACAGTTGCTGCGCCACAGGTGCAGCAGGTCCCG
GTCCTGGTCCAGCCTCAGATCATCAAGACAGATTCCCTTGTTTTGACCACACTGAAGACA
GATGGCAGCCCTGTTATGGCTGCGGTCCAGAACCCGGCCCTCACCGCCCTCACCACCCCT
ATCCAGACGGCTGCCCTTCAAGTACCAACCCTGGTGGGCAGCAGTGGGACCATTCTGACC
ACAATGCCTGTAATGATGGGGCAAGAGAAAGTGCCCATTAAGCAGGTACCTGGGGGAGTC
AAGCAGCTTGAGCCCCCCAAAGAAGGAGAAAGGCGGACAACCCATAATATCATTGAGAAA
CGATATCGCTCCTCCATCAATGACAAAATCATCGAATTGAAAGACCTGGTCATGGGGACA
GACGCCAAGATGCACAAGTCTGGCGTTCTGAGGAAGGCCATTGATTACATCAAATACTTG
CAGCAGGTCAATCATAAACTGCGCCAGGAGAACATGGTGCTGAAGCTGGCAAATCAAAAG
AACAAGCTTCTAAAGGGCATCGACCTAGGCAGTCTGGTGGACAATGAGGTGGACCTGAAG
ATCGAGGACTTTAATCAGAATGTCCTTCTGATGTCCCCCCCAGCCTCTGACTCAGGGTCC
CAGGCTGGCTTCTCTCCCTACTCCATTGACTCTGAGCCAGGAAGCCCTCTATTGGATGAT
GCAAAGGTCAAAGATGAGCCAGACTCTCCTCCTGTGGCGCTGGGCATGGTAGACCGCTCA
CGGATTCTTCTGTGTGTCCTCACCTTCCTGTGCCTCTCCTTTAACCCCCTGACTTCCCTG
CTGCAGTGGGGAGGGGCCCACGACTCTGACCAGCACCCACACTCAGGCTCTGGCCGCAGT
GTCCTGTCATTCGAGTCAGGTTCTGGGGGCTGGTTTGACTGGATGATGCCTACTCTTCTC
TTATGGCTGGTAAATGGTGTGATTGTCCTGAGCGTCTTTGTGAAGCTGCTGGTTCATGGG
GAGCCAGTGATCCGGCCACACTCGCGCTCCTCGGTCACCTTCTGGAGGCACCGGAAACAG
GCAGATCTGGATCTCGCCAGAGGAGATTTTGCAGCTGCTGCCGCCAACCTACAAACCTGC
CTGGCAGTTTTGGGCCGGGCACTGCCCACCTCCCGCCTGGACCTGGCCTGCAGCCTCTCC
TGGAACGTGATCCGCTACAGCCTGCAGAAGCTACGCCTGGTGCGCTGGCTGCTCAAGAAA
GTCTTCCAGTGCCGGCGGGCCACGCCAGCCACTGAGGCAGGCTTTGAAGACGAAGCTAAG
ACCAGCGCCCGGGATGCGGCTCTGGCCTATCACCGGCTGCACCAGCTGCACATCACAGGG
AAGCTTCCTGCAGGATCCGCCTGTTCCGATGTACACATGGCGTTGTGTGCCGTGAACCTG
GCTGAATGTGCAGAGGAGAAGATCCCACCGAGCACACTGGTTGAGATCCATCTGACTGCT
GCCATGGGGCTCAAGACCCGGTGTGGAGGCAAGCTGGGCTTCCTGGCCAGCTACTTCCTC
AGCCGAGCCCAGAGCCTGTGTGGCCCCGAGCACAGTGCTGTTCCTGACTCCCTGCGCTGG
CTCTGCCACCCCCTGGGCCAGAAGTTTTTCATGGAGCGGAGCTGGTCTGTGAAGTCAGCT
GCCAAGGAGAGTCTATACTGTGCCCAGAGGAACCCAGCTGACCCCATTGCGCAGGTCCAC
CAGGCCTTCTGCAAGAACCTGCTGGAGCGAGCTATAGAGTCCTTGGTGAAACCTCAGGCC
AAGAAGAAGGCTGGAGACCAGGAAGAAGAGAGCTGTGAATTCTCCAGTGCTCTGGAGTAC
TTGAAATTACTTCATTCTTTTGTGGACTCTGTGGGGGTTATGAGCCCCCCACTCTCCAGG
AGCTCCGTGCTCAAGTCCGCCCTGGGTCCAGACATCATCTGTCGGTGGTGGACGTCTGCA
ATCACTGTGGCCATCAGCTGGCTCCAGGGAGACGATGCAGCTGTGCGCTCTCATTTTACC
AAAGTGGAACGCATCCCCAAGGCCCTGGAAGTGACAGAGAGCCCCCTGGTGAAGGCCATC
TTCCATGCCTGCAGAGCCATGCATGCCTCACTCCCTGGGAAAGCAGATGGGCAGCAGAGT
TCCTTCTGCCATTGCGAGAGGGCCAGTGGCCACCTATGGAGCAGCCTCAACGTCAGTGGG
GGCACCTCTGACCCTGCCCTCAACCACGTGGTCCAGCTGCTCACCTGTGACCTGCTACTG
TCGCTACGGACAGCGCTCTGGCAAAAACAGGCCAGTGCCAGCCAGGCTGTGGGGGAGACC
TACCACGCGTCAGGCGCTGAACTGGCGGGCTTCCAACGGGACCTGGGCAGCCTGCGCAGG
CTGGCACACAGCTTCCGCCCAGCATACCGCAAGGTGTTCCTGCATGAAGCCACCGTGCGC
CTGATGGCAGGAGGCAGCCCCACCCGCACCCACCAGCTGCTGGAACACAGCCTGCGGCGG
CGCACCACGCAGAGCACCAAGCACGGAGAGGTGGATGCCTGGCCCGGCCAGCGAGAGCGG
GCCACCGCCATCCTGCTGGCCTGCCGCCACCTGCCCCTCTCCTTCCTCTCCTCCCCGGGC
CAGCGGGCAGTGCTGCTGGCCGAAGCTGCCCGCACCCTGGAGAAGGTGGGCGACCGGCGC
TCCTGCAACGACTGCCAGCAGATGATTGTTAAGCTGGGTGGTGGCACTGCCATTGCCGCC
TCCTGA

# Macromolecular_Interacting_Partner_26_GenBank_ID_Gene:
U02031

# Macromolecular_Interacting_Partner_26_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_26_Locus:
22q13

# Macromolecular_Interacting_Partner_26_SNPs:
rs4822063; rs2229440; rs11547820; rs9623465; rs2229442; rs4822067; rs2269664; rs2157590; rs1052717; rs1009544; rs133281; rs714015; rs133291; rs9620000; rs4822064; rs5996078; rs7287886; rs5996077; rs5996080; rs9623468; rs2255957; rs2269658; rs9623466; rs6002521; rs9623467; rs133280; rs9607852; rs4822066; rs9623469; rs11702960; rs133290; rs6002522; rs2839713; rs2269657; rs133286; rs6002524; rs4822062; rs2006638; rs6002527; rs2267438; rs17002737; rs1894710; rs6002529; rs2284084; rs2269660; rs11912825; rs7292752; rs12157312; rs2267443; rs4501042; rs1569451; rs2017128; rs2267439; rs17002745; rs6002512; rs6002526; rs5996081; rs17379759; rs2269661; rs8141414; rs12373973; rs713881; rs1883205; rs2284082; rs4820447; rs2413660; rs5996083; rs12165579; rs7287010; rs80720; rs8140090; rs1124998; rs2269662; rs16985978; rs719440; rs5751173; rs4269017; rs2839715; rs9607851; rs17002741; rs9611685; rs17002749; rs133287; rs8140028; rs9607850; rs2267442; rs6519294; rs2284085; rs7291578; rs12628217; rs4822061; rs9611677; rs9611679; rs5996079; rs2267440; rs2284083; rs13055841; rs9611680; rs2269663; rs2284086; rs9607849; rs5996084; rs7288838; rs7286071; rs17002706; rs12628192; rs7288536; rs5751174; rs12166430; rs9611683; rs6519292; rs11912986; rs6519293; rs7291503; rs9611686; rs11704997; rs5996074; rs17002747; rs2269659; rs6002530; rs11704061; rs1132781; rs11547823; rs6002520; rs17848351; rs11547822; rs17002714; rs11538312; rs11547821; rs17848337; rs11913460; rs35259415; rs2229438; rs873638; rs17848343; rs35306119; rs13057539; rs35684615; rs8142691; rs34700704; rs11703550; rs3045463; rs17848352; rs1060487; rs5758494; rs12158584; rs34333405; rs133288; rs8143158; rs34701406; rs35368983; rs8137847; rs28452214; rs9611676; rs5758498; rs3833965; rs9623464; rs34300977; rs9611690; rs9789917; rs133285; rs17848345; rs9611682; rs7292219; rs5758496; rs36011955; rs10701628; rs6002513; rs36109229; rs12169105; rs3045439; rs34394290; rs12162922; rs3045466; rs35473174; rs12373989; rs13057991; rs12166862; rs35645166; rs35251023; rs35108023; rs11268671; rs17848336; rs34256306; rs9607854; rs10588397; rs35810171; rs17848348; rs9611687; rs6002511; rs5751172; rs9623463; rs5758490; rs1137594; rs728764; rs5758495; rs4998806; rs35817214; rs8138841; rs4456793; rs13058481; rs12171023; rs17848335; rs34424722; rs34902938; rs12170242; rs5845512; rs1137595; rs9611689; rs5751170; rs133282; rs2413661; rs5758492; rs9623471; rs28391727; rs7293096; rs28759251; rs6002509; rs35493864; rs8141218; rs5996076; rs34318619; rs12628154; rs34459727; rs6002517; rs12169940; rs34641582; rs12169983; rs5758501; rs34510654; rs4991804; rs28517532; rs17848346; rs36006070; rs5751176; rs744011; rs34153466; rs133284; rs10608168; rs12167811; rs5758497; rs9611681; rs11343843; rs12170354; rs35030018; rs6002518; rs35054500; rs133289; rs11462946; rs6002515; rs28885520; rs28869235; rs34587252; rs9623459; rs12166914; rs34310876; rs3788586; rs2267441; rs2839714; rs11464032; rs28407826; rs5758493; rs4572703; rs34355645; rs28873512; rs3045465; rs34605689; rs34704587; rs13058611; rs5845515; rs6002528; rs6002510; rs12627860; rs35676452; rs12168347; rs9611688; rs35293379; rs34796148; rs35207281; rs34718352; rs7292386; rs4822060; rs12170228; rs5751171; rs41276325; rs12171005; rs35621588; rs9607853; rs10222269; rs11392724; rs8140722; rs5845513; rs10612254; rs6002516; rs12171029; rs5996075; rs12169026; rs12169031; rs5758488; rs28666835; rs10612450; rs8140908; rs34718055; rs8139585; rs3216440; rs133279; rs133283; rs2413662; rs35089584; rs9611678; rs34410444; rs12159835; rs6002519; rs35946363; rs11390422; rs12628170; rs11448839; rs6002514; rs35394333; rs11361634; rs11292056; rs11319802; rs11703214; rs34787905; rs9623473; rs11321672; rs41277471; rs41277469; rs9611675; rs34177566; rs34344173; rs34003333; rs11705632; rs12162958; rs12627760; rs1894711; rs4822056; rs5758487; rs6002506; rs7285782; rs8988

# Macromolecular_Interacting_Partner_26_General_References:
7903453; 10591208; 8402897; 8626610; 8643593

# Macromolecular_Interacting_Partner_26_References:
16936198; 16946405; 17126302

# Macromolecular_Interacting_Partner_27_ID:
7773

# Macromolecular_Interacting_Partner_27_Name:
ATP-binding cassette sub-family G member 8

# Macromolecular_Interacting_Partner_27_Synonyms:
Sterolin-2

# Macromolecular_Interacting_Partner_27_Gene_Name:
ABCG8

# Macromolecular_Interacting_Partner_27_Protein_Sequence:
>ATPbinding cassette subfamily G member 8
MAGKAAEERGLPKGATPQDTSGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLAS
QVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITG
RGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFS
QAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPT
SGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHM
VQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFL
WKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQISNDFRDLPTLLIH
GAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFNVILDVISKCYSERAMLYY
ELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVF
CCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCF
EGLMKIQFSRRTYKMPLGNLTIAVSGDKILSVMELDSYPLYAIYLIVIGLSGGFMVLYYV
SLRFIKQKPSQDW

# Macromolecular_Interacting_Partner_27_Number_of_Residues:
673

# Macromolecular_Interacting_Partner_27_Molecular_Weight:
75680

# Macromolecular_Interacting_Partner_27_Theoretical_pI:
8.29

# Macromolecular_Interacting_Partner_27_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  ATPase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_27_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_27_Specific_Function:
Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile

# Macromolecular_Interacting_Partner_27_Pathway:
Not Available

# Macromolecular_Interacting_Partner_27_Reaction:
Not Available

# Macromolecular_Interacting_Partner_27_Pfam_Domain_Function:
PF01061:ABC2_membrane;
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_27_Signals:
None

# Macromolecular_Interacting_Partner_27_Transmembrane_Regions:
417-437
448-468
493-513
532-552
570-590
640-660

# Macromolecular_Interacting_Partner_27_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_27_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_27_GenBank_ID_Protein:
11692802

# Macromolecular_Interacting_Partner_27_SwissProt_ID:
ABCG8_HUMAN (Q9H221)

# Macromolecular_Interacting_Partner_27_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_27_Genecard_id:
ABCG8

# Macromolecular_Interacting_Partner_27_Geneatlas_id:
ABCG8

# Macromolecular_Interacting_Partner_27_hgnc_id:
HGNC:13887

# Macromolecular_Interacting_Partner_27_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_27_Subcellular_Location:
Membrane; multi-pass membrane protein (Probable)

# Macromolecular_Interacting_Partner_27_Gene_Sequence:
>2022 bp
ATGGCCGGGAAGGCGGCAGAGGAGAGAGGGCTGCCGAAAGGGGCCACTCCCCAGGATACC
TCGGGCCTCCAGGATAGATTGTTCTCCTCTGAAAGTGACAACAGCCTGTACTTCACCTAC
AGTGGCCAGCCCAACACCCTGGAGGTCAGAGACCTCAACTACCAGGTGGACCTGGCCTCT
CAGGTCCCTTGGTTTGAGCAGCTGGCTCAGTTCAAGATGCCCTGGACATCTCCCAGCTGC
CAGAATTCTTGTGAGCTGGGCATCCAGAACCTAAGCTTCAAAGTGAGAAGTGGGCAGATG
CTGGCCATCATAGGGAGCTCAGGTTGTGGGAGAGCCTCCTTGCTAGATGTGATCACTGGC
CGAGGTCACGGCGGCAAGATCAAGTCAGGCCAGATCTGGATCAATGGGCAGCCCAGCTCG
CCTCAGCTGGTGAGGAAGTGTGTGGCCCACGTGCGCCAGCACAACCAGCTGCTCCCCAAC
TTGACTGTGCGAGAGACCTTGGCCTTCATTGCCCAGATGCGGCTGCCCAGAACCTTCTCC
CAGGCCCAGCGTGACAAAAGGGTGGAGGACGTGATCGCGGAGCTGCGGCTTAGGCAGTGC
GCTGACACCCGCGTGGGCAACATGTACGTGCGGGGGTTGTCGGGGGGTGAGCGCAGGAGA
GTCAGCATTGGGGTGCAGCTCCTGTGGAACCCAGGAATCCTTATTCTCGACGAACCCACC
TCTGGGCTCGACAGCTTCACAGCCCACAACCTGGTGAAGACCTTGTCCAGGCTGGCCAAA
GGCAACCGGCTGGTGCTCATCTCCCTCCACCAGCCTCGCTCTGACATCTTCAGGCTGTTT
GATCTGGTCCTCCTGATGACGTCTGGCACCCCCATCTACTTAGGGGCGGCCCAGCACATG
GTCCAGTATTTCACAGCCATCGGCTACCCCTGTCCTCGCTACAGCAATCCTGCTGACTTC
TATGTGGACCTGACCAGCATTGACAGGCGCAGCAGAGAGCAGGAATTGGCCACCAGGGAG
AAGGCTCAGTCACTCGCAGCCCTGTTTCTAGAAAAAGTGCGTGACTTAGATGACTTTCTA
TGGAAAGCAGAGACGAAGGATCTTGACGAGGACACCTGTGTGGAAAGCAGCGTGACCCCA
CTAGACACCAACTGCCTCCCGAGTCCTACGAAGATGCCTGGGGCGGTGCAGCAGTTTACG
ACGCTGATCCGTCGTCAGATTTCCAACGACTTCCGAGACCTGCCCACCCTCCTCATCCAT
GGGGCGGAGGCCTGTCTGATGTCAATGACCATCGGCTTCCTCTATTTTGGCCATGGGAGC
ATCCAGCTCTCCTTCATGGATACAGCCGCCCTCTTGTTCATGATCGGTGCTCTCATCCCT
TTCAACGTCATTCTGGATGTCATCTCCAAATGTTACTCAGAGAGGGCAATGCTTTACTAT
GAACTGGAAGACGGGCTGTACACCACTGGTCCATATTTCTTTGCCAAGATCCTCGGGGAG
CTTCCGGAGCACTGTGCCTACATCATCATCTACGGGATGCCCACCTACTGGCTGGCCAAC
CTGAGGCCAGGCCTCCAGCCCTTCCTGCTGCACTTCCTGCTGGTGTGGCTGGTGGTCTTC
TGTTGCAGGATTATGGCCCTGGCCGCCGCGGCCCTGCTCCCCACCTTCCACATGGCCTCC
TTCTTCAGCAATGCCCTCTACAACTCCTTCTACCTCGCCGGGGGCTTCATGATAAACTTG
AGCAGCCTGTGGACAGTGCCCGCGTGGATTTCCAAAGTGTCCTTCCTGCGGTGGTGTTTT
GAAGGGCTGATGAAGATTCAGTTCAGCAGAAGAACTTATAAAATGCCTCTCGGGAACCTC
ACCATCGCGGTCTCAGGAGATAAAATCCTCAGTGTCATGGAGCTGGACTCGTACCCTCTC
TACGCCATCTACCTCATCGTCATTGGCCTCAGCGGTGGCTTCATGGTCCTGTACTACGTG
TCCTTAAGGTTCATCAAACAGAAACCAAGTCAAGACTGGTGA

# Macromolecular_Interacting_Partner_27_GenBank_ID_Gene:
AF320294

# Macromolecular_Interacting_Partner_27_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_27_Locus:
2p21

# Macromolecular_Interacting_Partner_27_SNPs:
rs4148211; rs4148217; rs6544718; rs9282574; rs35518570; rs9282573; rs4148221; rs9282575; rs4245795; rs4148214; rs4077440; rs6544717; rs4148206; rs6718187; rs6544713; rs4603817; rs4148210; rs4245794; rs6720518; rs4314040; rs6756778; rs6709904; rs4953028; rs4299376; rs4245793; rs6755809; rs4603816; rs4148204; rs4148209; rs3795860; rs4952689; rs6756676; rs4245792; rs6748810; rs6752551; rs4148205; rs10174731; rs11685669; rs6544714; rs4952687; rs4245791; rs10179921; rs13421669; rs4952688; rs10202258; rs4148213; rs10186958; rs4132010; rs4550709; rs6714800; rs6544716; rs6735229; rs4148218; rs4507143; rs17606027; rs4148208; rs6544715; rs4953022; rs17039142; rs13405698; rs13390041; rs17031742; rs7580380; rs9973482; rs4148212; rs17031711; rs9753033; rs4496372; rs7601130; rs11694811; rs4076835; rs10182584; rs4953025; rs17424122; rs9282572; rs6740545; rs13395859; rs4953024; rs6733452; rs4148219; rs6737524; rs4148222; rs12479089; rs17031713; rs9282576; rs12329388; rs10221914; rs4953023; rs17031710; rs17039139; rs11124950; rs9309109; rs4148216; rs10210428; rs7590687; rs12468591; rs9973811; rs4953026; rs13430143; rs4148220; rs4076834; rs6732359; rs4148215; rs9679574; rs12329390; rs2954801; rs17031744; rs34754243; rs41281459; rs4148229; rs13001346; rs11405271; rs5830775; rs34198326; rs34796648; rs34594519; rs13400725; rs2955282; rs5830771; rs10165563; rs34073358; rs35771299; rs3841852; rs4496373; rs4148224; rs4148225; rs12991878; rs35655489; rs11454812; rs34706968; rs5830772; rs35722629; rs13001164; rs11124949; rs35193905; rs35927760; rs35854771; rs35328975; rs4614977; rs36018247; rs35567929; rs10541565; rs34343784; rs28517482; rs4076833; rs28429480; rs5830773; rs7599769; rs3820734; rs4148227; rs4507142; rs11397066; rs10182672; rs41281461; rs35533254; rs13025096; rs35339332; rs10609687; rs7598542; rs34384446; rs5830774; rs35426025; rs4300882; rs13025277; rs13415632; rs13024740; rs10709506; rs41360247; rs34798399; rs35675134; rs11455022; rs35206901; rs11676159; rs35648030; rs10177200; rs10495909; rs1136998; rs11688719; rs11887534; rs17031753; rs17424261; rs17578296; rs2954802; rs2954804; rs2954805; rs2954806; rs2954807; rs2955279; rs3806470; rs3806471; rs3923911; rs4131228; rs4131229; rs4148177; rs4148178; rs4148179; rs4148180; rs4148181; rs4148182; rs4148183; rs4148185; rs4148202; rs4148203; rs4148207; rs4245796; rs4953020; rs4953027; rs4953029; rs4953030; rs4953031; rs6756629; rs7577294; rs7580868; rs7599981; rs8057

# Macromolecular_Interacting_Partner_27_General_References:
11099417; 11452359; 11590207; 12111378

# Macromolecular_Interacting_Partner_27_References:
17058264

# Macromolecular_Interacting_Partner_28_ID:
7766

# Macromolecular_Interacting_Partner_28_Name:
ATP-binding cassette sub-family G member 5

# Macromolecular_Interacting_Partner_28_Synonyms:
Sterolin-1

# Macromolecular_Interacting_Partner_28_Gene_Name:
ABCG5

# Macromolecular_Interacting_Partner_28_Protein_Sequence:
>ATPbinding cassette subfamily G member 5
MGDLSSLTPGGSMGLQVNRGSQSSLEGAPATAPEPHSLGILHASYSVSHRVRPWWDITSC
RQQWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRAL
RREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHV
ADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELAR
RNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPFDF
YMDLTSVDTQSKEREIETSKRVQMIESAYKKSAICHKTLKNIERMKHLKTLPMVPFKTKD
SPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLFLLFFVLRVRSNVLKGAIQDRV
GLLYQFVGATPYTGMLNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATM
IFSSVCYWTLGLHPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIVNSVVALLSIA
GVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYGLNFTCGSSNVSVTTNPMC
AFTQGIQFIEKTCPGATSRFTMNFLILYSFIPALVILGIVVFKIRDHLISR

# Macromolecular_Interacting_Partner_28_Number_of_Residues:
651

# Macromolecular_Interacting_Partner_28_Molecular_Weight:
72505

# Macromolecular_Interacting_Partner_28_Theoretical_pI:
9.17

# Macromolecular_Interacting_Partner_28_GO_Classification:
>>>
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_28_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_28_Specific_Function:
Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile

# Macromolecular_Interacting_Partner_28_Pathway:
Not Available

# Macromolecular_Interacting_Partner_28_Reaction:
Not Available

# Macromolecular_Interacting_Partner_28_Pfam_Domain_Function:
PF01061:ABC2_membrane;
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_28_Signals:
None

# Macromolecular_Interacting_Partner_28_Transmembrane_Regions:
384-404
422-442
463-483
504-524
529-549
624-644

# Macromolecular_Interacting_Partner_28_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_28_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_28_GenBank_ID_Protein:
11692800

# Macromolecular_Interacting_Partner_28_SwissProt_ID:
ABCG5_HUMAN (Q9H222)

# Macromolecular_Interacting_Partner_28_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_28_Genecard_id:
ABCG5

# Macromolecular_Interacting_Partner_28_Geneatlas_id:
ABCG5

# Macromolecular_Interacting_Partner_28_hgnc_id:
HGNC:13886

# Macromolecular_Interacting_Partner_28_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_28_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_28_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_28_Subcellular_Location:
Membrane; multi-pass membrane protein (Probable)

# Macromolecular_Interacting_Partner_28_Gene_Sequence:
>1956 bp
ATGGGTGACCTCTCATCTTTGACCCCCGGAGGGTCCATGGGTCTCCAAGTAAACAGAGGC
TCCCAGAGCTCCCTGGAGGGGGCTCCTGCCACCGCCCCGGAGCCTCACAGCCTGGGCATC
CTCCATGCCTCCTACAGCGTCAGCCACCGCGTGAGGCCCTGGTGGGACATCACATCTTGC
CGGCAGCAGTGGACCAGGCAGATCCTCAAAGATGTCTCCTTGTACGTGGAGAGCGGGCAG
ATCATGTGCATCCTAGGAAGCTCAGGCTCCGGGAAAACCACGCTGCTGGACGCCATGTCC
GGGAGGCTGGGGCGCGCGGGGACCTTCCTGGGGGAGGTGTATGTGAACGGCCGGGCGCTG
CGCCGGGAGCAGTTCCAGGACTGCTTCTCCTACGTCCTGCAGAGCGACACCCTGCTGAGC
AGCCTCACCGTGCGCGAGACGCTGCACTACACCGCGCTGCTGGCCATCCGCCGCGGCAAT
CCCGGCTCCTTCCAGAAGAAGGTGGAGGCCGTCATGGCAGAGCTGAGTCTGAGCCATGTG
GCAGACCGACTGATTGGCAACTACAGCTTGGGGGGCATTTCCACGGGTGAGCGGCGCCGG
GTCTCCATCGCAGCCCAGCTGCTCCAGGATCCTAAGGTCATGCTGTTTGATGAGCCAACC
ACAGGCCTGGACTGCATGACTGCTAATCAGATTGTCGTCCTCCTGGTGGAACTGGCTCGC
AGGAACCGAATTGTGGTTCTCACCATTCACCAGCCCCGTTCTGAGCTTTTTCAGCTCTTT
GACAAAATTGCCATCCTGAGCTTCGGAGAGCTGATTTTCTGTGGCACGCCAGCGGAAATG
CTTGATTTCTTCAATGACTGCGGTTACCCTTGTCCTGAACATTCAAACCCTTTTGACTTC
TATATGGACCTGACGTCAGTGGATACCCAAAGCAAGGAACGGGAAATAGAAACCTCCAAG
AGAGTCCAGATGATAGAATCTGCCTACAAGAAATCAGCAATTTGTCATAAAACTTTGAAG
AATATTGAAAGAATGAAACACCTGAAAACGTTACCAATGGTTCCTTTCAAAACCAAAGAT
TCTCCTGGAGTTTTCTCTAAACTGGGTGTTCTCCTGAGGAGAGTGACAAGAAACTTGGTG
AGAAATAAGCTGGCAGTGATTACGCGTCTCCTTCAGAATCTGATCATGGGTTTGTTCCTC
CTTTTCTTCGTTCTGCGGGTCCGAAGCAATGTGCTAAAGGGTGCTATCCAGGACCGCGTA
GGTCTCCTTTACCAGTTTGTGGGCGCCACCCCGTACACAGGCATGCTGAACGCTGTGAAT
CTGTTTCCCGTGCTGCGAGCTGTCAGCGACCAGGAGAGTCAGGACGGCCTCTACCAGAAG
TGGCAGATGATGCTGGCCTATGCACTGCACGTCCTCCCCTTCAGCGTTGTTGCCACCATG
ATTTTCAGCAGTGTGTGCTACTGGACGCTGGGCTTACATCCTGAGGTTGCCCGATTTGGA
TATTTTTCTGCTGCTCTCTTGGCCCCCCACTTAATTGGTGAATTTCTAACTCTTGTGCTA
CTTGGTATCGTCCAAAATCCAAATATAGTCAACAGTGTAGTGGCTCTGCTGTCCATTGCG
GGGGTGCTTGTTGGATCTGGATTCCTCAGAAACATACAAGAAATGCCCATTCCTTTTAAA
ATCATCAGTTATTTTACATTCCAAAAATATTGCAGTGAGATTCTTGTAGTCAATGAGTTC
TACGGACTGAATTTCACTTGTGGCAGCTCAAATGTTTCTGTGACAACTAATCCAATGTGT
GCCTTCACTCAAGGAATTCAATTCATTGAGAAAACCTGCCCAGGTGCAACATCTAGATTC
ACAATGAACTTTCTGATTTTGTATTCATTTATTCCAGCTCTTGTCATCCTAGGAATAGTT
GTTTTCAAAATAAGGGATCATCTCATTAGCAGGTAG

# Macromolecular_Interacting_Partner_28_GenBank_ID_Gene:
AF320293

# Macromolecular_Interacting_Partner_28_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_28_Locus:
2p21

# Macromolecular_Interacting_Partner_28_SNPs:
rs6720173; rs17031672; rs2278357; rs2278356; rs4148195; rs10208987; rs4953019; rs10205816; rs4148194; rs1864815; rs4148189; rs4245786; rs4148178; rs4148188; rs4148182; rs4148184; rs4148179; rs4148191; rs4148193; rs4148192; rs4148187; rs4131229; rs4953020; rs4148185; rs4148180; rs4289236; rs11891859; rs1864814; rs4953021; rs4245787; rs4148181; rs4557032; rs10439467; rs6544712; rs11686966; rs4245788; rs17031664; rs6761611; rs4549146; rs17031651; rs6707683; rs13396273; rs4148177; rs7596134; rs4131228; rs17031692; rs10201851; rs3923911; rs7423086; rs17031666; rs6712582; rs6741243; rs17031663; rs17031655; rs13425260; rs6758582; rs17031687; rs17031675; rs4073237; rs6729865; rs6716572; rs17031678; rs7608721; rs11897993; rs7587792; rs3923912; rs13425681; rs6716451; rs4148183; rs17031700; rs4148186; rs6728053; rs7599296; rs4148196; rs4952686; rs4952684; rs10180615; rs4952685; rs4076029; rs35636239; rs4148198; rs34520479; rs34374271; rs13418826; rs34700971; rs34829025; rs11405961; rs13011117; rs4073349; rs4148175; rs34424134; rs34967943; rs4148197; rs4148174; rs35218175; rs12999403; rs10187445; rs13406911; rs10198297; rs13000152; rs10578398; rs4148176; rs4073238; rs12468988; rs9789463; rs34401695; rs35561346; rs4488709; rs35465637; rs10169893; rs4148190; rs35746308; rs13427362; rs10180748; rs10581048; rs10177200; rs10177630; rs10179921; rs10186086; rs10186552; rs10194949; rs10495909; rs11556154; rs11887534; rs12987875; rs13015330; rs1432278; rs17031599; rs17031602; rs17031616; rs17031619; rs17031630; rs17031635; rs17031638; rs17031710; rs17031711; rs17031713; rs17039139; rs17039142; rs17424122; rs1835815; rs2116547; rs2116548; rs3792008; rs3792009; rs3792010; rs3792011; rs3792012; rs3806470; rs3806471; rs3828296; rs4148202; rs4148203; rs4148204; rs4148205; rs4148206; rs4148207; rs4148208; rs4148210; rs4148211; rs4245791; rs4299376; rs4952679; rs4952680; rs4952683; rs4953018; rs4953023; rs6544713; rs6720518; rs6748810; rs6756629; rs7564925; rs8302

# Macromolecular_Interacting_Partner_28_General_References:
11099417; 11138003; 11590207; 11452359

# Macromolecular_Interacting_Partner_28_References:
17058264

# Macromolecular_Interacting_Partner_29_ID:
8279

# Macromolecular_Interacting_Partner_29_Name:
Niemann-Pick C1-like protein 1 precursor

# Macromolecular_Interacting_Partner_29_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_29_Gene_Name:
NPC1L1

# Macromolecular_Interacting_Partner_29_Protein_Sequence:
>NiemannPick C1like protein 1 precursor
MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSN
TPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNF
VNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAA
ATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGV
ARCNESQGDDVATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTI
LLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSV
IPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSY
RYDSLLLGPKNFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNT
SLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALAL
SCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEM
RAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRV
MVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLE
YQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAV
ILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPFL
LHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPV
YFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDW
LTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRP
NIKCPKGGLAAYSTSVNLTSDGQVLDTVAILSPRLEYSGTISAHCNLYLLDSASRFMAYH
KPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGL
FMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVS
AVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQ
LIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPALALEQKRAEEAVAAVMVASCP
NHPSRVSTADNIYVNHSFEGSIKGAGAISNFLPNNGRQF

# Macromolecular_Interacting_Partner_29_Number_of_Residues:
1359

# Macromolecular_Interacting_Partner_29_Molecular_Weight:
148700

# Macromolecular_Interacting_Partner_29_Theoretical_pI:
6.31

# Macromolecular_Interacting_Partner_29_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  hedgehog receptor activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  lipid transport
Process:  sterol transport
Process:  cholesterol transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_29_General_Function:
Not Available

# Macromolecular_Interacting_Partner_29_Specific_Function:
Play a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorbtion. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism

# Macromolecular_Interacting_Partner_29_Pathway:
Not Available

# Macromolecular_Interacting_Partner_29_Reaction:
Not Available

# Macromolecular_Interacting_Partner_29_Pfam_Domain_Function:
PF02460:Patched

# Macromolecular_Interacting_Partner_29_Signals:
1-21

# Macromolecular_Interacting_Partner_29_Transmembrane_Regions:
285-305
352-372
633-653
667-687
697-717
743-763
777-797
847-867
883-903
1140-1160
1169-1189
1192-1212
1237-1257

# Macromolecular_Interacting_Partner_29_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_29_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_29_GenBank_ID_Protein:
6643036

# Macromolecular_Interacting_Partner_29_SwissProt_ID:
NPCL1_HUMAN (Q9UHC9)

# Macromolecular_Interacting_Partner_29_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_29_Genecard_id:
NPC1L1

# Macromolecular_Interacting_Partner_29_Geneatlas_id:
NPC1L1

# Macromolecular_Interacting_Partner_29_hgnc_id:
HGNC:7898

# Macromolecular_Interacting_Partner_29_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_29_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_29_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_29_Subcellular_Location:
Cell membrane; apical cell membrane; multi- pass membrane protein. Cell membrane; multi-pass membrane protein. Cytoplasmic vesicle; cytoplasmic vesicle membrane; multi-pass membrane protein. Note=Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to Ref.3, localizes in a subcellular vesicular compartment rich in RAB5

# Macromolecular_Interacting_Partner_29_Gene_Sequence:
>4080 bp
ATGGCGGAGGCCGGCCTGAGGGGCTGGCTGCTGTGGGCCCTGCTCCTGCGCTTGGCCCAG
AGTGAGCCTTACACAACCATCCACCAGCCTGGCTACTGCGCCTTCTATGACGAATGTGGG
AAGAACCCAGAGCTGTCTGGAAGCCTCATGACACTCTCCAACGTGTCCTGCCTGTCCAAC
ACGCCGGCCCGCAAGATCACAGGTGATCACCTGATCCTATTACAGAAGATCTGCCCCCGC
CTCTACACCGGCCCCAACACCCAAGCCTGCTGCTCCGCCAAGCAGCTGGTATCACTGGAA
GCGAGTCTGTCGATCACCAAGGCCCTCCTCACCCGCTGCCCAGCCTGCTCTGACAATTTT
GTGAACCTGCACTGCCACAACACGTGCAGCCCCAATCAGAGCCTCTTCATCAATGTGACC
CGCGTGGCCCAGCTAGGGGCTGGACAACTCCCAGCTGTGGTGGCCTATGAGGCCTTCTAC
CAGCATAGCTTTGCCGAGCAGAGCTATGACTCCTGCAGCCGTGTGCGCGTCCCTGCAGCT
GCCACGCTGGCTGTGGGCACCATGTGTGGCGTGTATGGCTCTGCCCTTTGCAATGCCCAG
CGCTGGCTCAACTTCCAGGGAGACACAGGCAATGGTCTGGCCCCACTGGACATCACCTTC
CACCTCTTGGAGCCTGGCCAGGCCGTGGGGAGTGGGATTCAGCCTCTGAATGAGGGGGTT
GCACGTTGCAATGAGTCCCAAGGTGACGACGTGGCGACCTGCTCCTGCCAAGACTGTGCT
GCATCCTGTCCTGCCATAGCCCGCCCCCAGGCCCTCGACTCCACCTTCTACCTGGGCCAG
ATGCCGGGCAGTCTGGTCCTCATCATCATCCTCTGCTCTGTCTTCGCTGTGGTCACCATC
CTGCTTGTGGGATTCCGTGTGGCCCCCGCCAGGGACAAAAGCAAGATGGTGGACCCCAAG
AAGGGCACCAGCCTCTCTGACAAGCTCAGCTTCTCCACCCACACCCTCCTTGGCCAGTTC
TTCCAGGGCTGGGGCACGTGGGTGGCTTCGTGGCCTCTGACCATCTTGGTGCTATCTGTC
ATCCCGGTGGTGGCCTTGGCAGCGGGCCTGGTCTTTACAGAACTCACTACGGACCCCGTG
GAGCTGTGGTCGGCCCCCAACAGCCAAGCCCGGAGTGAGAAAGCTTTCCATGACCAGCAT
TTCGGCCCCTTCTTCCGAACCAACCAGGTGATCCTGACGGCTCCTAACCGGTCCAGCTAC
AGGTATGACTCTCTGCTGCTGGGGCCCAAGAACTTCAGCGGAATCCTGGACCTGGACTTG
CTGCTGGAGCTGCTAGAGCTGCAGGAGAGGCTGCGGCACCTCCAGGTATGGTCGCCCGAA
GCACAGCGCAACATCTCCCTGCAGGACATCTGCTACGCCCCCCTCAATCCGGACAATACC
AGTCTCTACGACTGCTGCATCAACAGCCTCCTGCAGTATTTCCAGAACAACCGCACGCTC
CTGCTGCTCACAGCCAACCAGACACTGATGGGGCAGACCTCCCAAGTCGACTGGAAGGAC
CATTTTCTGTACTGTGCCAATGCCCCGCTCACCTTCAAGGATGGCACAGCCCTGGCCCTG
AGCTGCATGGCTGACTACGGGGCCCCTGTCTTCCCCTTCCTTGCCATTGGGGGGTACAAA
GGAAAGGACTATTCTGAGGCAGAGGCCCTGATCATGACGTTCTCCCTCAACAATTACCCT
GCCGGGGACCCCCGTCTGGCCCAGGCCAAGCTGTGGGAGGAGGCCTTCTTAGAGGAAATG
CGAGCCTTCCAGCGTCGGATGGCTGGCATGTTCCAGGTCACGTTCATGGCTGAGCGCTCT
CTGGAAGACGAGATCAATCGCACCACAGCTGAAGACCTGCCCATCTTTGCCACCAGCTAC
ATTGTCATATTCCTGTACATCTCTCTGGCCCTGGGCAGCTATTCCAGCTGGAGCCGAGTG
ATGGTGGACTCCAAGGCCACGCTGGGCCTCGGCGGGGTGGCCGTGGTCCTGGGAGCAGTC
ATGGCTGCCATGGGCTTCTTCTCCTACTTGGGTATCCGCTCCTCCCTGGTCATCCTGCAA
GTGGTTCCTTTCCTGGTGCTGTCCGTGGGGGCTGATAACATCTTCATCTTTGTTCTCGAG
TACCAGAGGCTGCCCCGGAGGCCTGGGGAGCCACGAGAGGTCCACATTGGGCGAGCCCTA
GGCAGGGTGGCTCCCAGCATGCTGTTGTGCAGCCTCTCTGAGGCCATCTGCTTCTTCCTA
GGGGCCCTGACCCCCATGCCAGCTGTGCGGACCTTTGCCCTGACCTCTGGCCTTGCAGTG
ATCCTTGACTTCCTCCTGCAGATGTCAGCCTTTGTGGCCCTGCTCTCCCTGGACAGCAAG
AGGCAGGAGGCCTCCCGGTTGGACGTCTGCTGCTGTGTCAAGCCCCAGGAGCTGCCCCCG
CCTGGCCAGGGAGAGGGGCTCCTGCTTGGCTTCTTCCAAAAGGCTTATGCCCCCTTCCTG
CTGCACTGGATCACTCGAGGTGTTGTGCTGCTGCTGTTTCTCGCCCTGTTCGGAGTGAGC
CTCTACTCCATGTGCCACATCAGCGTGGGACTGGACCAGGAGCTGGCCCTGCCCAAGGAC
TCGTACCTGCTTGACTATTTCCTCTTTCTGAACCGCTACTTCGAGGTGGGGGCCCCGGTG
TACTTTGTTACCACCTTGGGCTACAACTTCTCCAGCGAGGCTGGGATGAATGCCATCTGC
TCCAGTGCAGGCTGCAACAACTTCTCCTTCACCCAGAAGATCCAGTATGCCACAGAGTTC
CCTGAGCAGTCTTACCTGGCCATCCCTGCCTCCTCCTGGGTGGATGACTTCATTGACTGG
CTGACCCCGTCCTCCTGCTGCCGCCTTTATATATCTGGCCCCAATAAGGACAAGTTCTGC
CCCTCGACCGTCAACTCTCTGAACTGCCTAAAGAACTGCATGAGCATCACGATGGGCTCT
GTGAGGCCCTCGGTGGAGCAGTTCCATAAGTATCTTCCCTGGTTCCTGAACGACCGGCCC
AACATCAAATGTCCCAAAGGCGGCCTGGCAGCATACAGCACCTCTGTGAACTTGACTTCA
GATGGCCAGGTTTTAGACACAGTTGCCATTCTGTCACCCAGGCTGGAGTACAGTGGCACA
ATCTCGGCTCACTGCAACCTCTACCTCCTGGATTCAGCCTCCAGGTTCATGGCCTATCAC
AAGCCCCTGAAAAACTCACAGGATTACACAGAAGCTCTGCGGGCAGCTCGAGAGCTGGCA
GCCAACATCACTGCTGACCTGCGGAAAGTGCCTGGAACAGACCCGGCTTTTGAGGTCTTC
CCCTACACGATCACCAATGTGTTTTATGAGCAGTACCTGACCATCCTCCCTGAGGGGCTC
TTCATGCTCAGCCTCTGCCTTGTGCCCACCTTCGCTGTCTCCTGCCTCCTGCTGGGCCTG
GACCTGCGCTCCGGCCTCCTCAACCTGCTCTCCATTGTCATGATCCTCGTGGACACTGTC
GGCTTCATGGCCCTGTGGGGCATCAGTTACAATGCTGTGTCCCTCATCAACCTGGTCTCG
GCGGTGGGCATGTCTGTGGAGTTTGTGTCCCACATTACCCGCTCCTTTGCCATCAGCACC
AAGCCCACCTGGCTGGAGAGGGCCAAAGAGGCCACCATCTCTATGGGAAGTGCGGTGTTT
GCAGGTGTGGCCATGACCAACCTGCCTGGCATCCTTGTCCTGGGCCTCGCCAAGGCCCAG
CTCATTCAGATCTTCTTCTTCCGCCTCAACCTCCTGATCACTCTGCTGGGCCTGCTGCAT
GGCTTGGTCTTCCTGCCCGTCATCCTCAGCTACGTGGGGCCTGACGTTAACCCGGCTCTG
GCACTGGAGCAGAAGCGGGCTGAGGAGGCGGTGGCAGCAGTCATGGTGGCCTCTTGCCCA
AATCACCCCTCCCGAGTCTCCACAGCTGACAACATCTATGTCAACCACAGCTTTGAAGGT
TCTATCAAAGGTGCTGGTGCCATCAGCAACTTCTTGCCCAACAATGGGCGGCAGTTCTGA


# Macromolecular_Interacting_Partner_29_GenBank_ID_Gene:
AF192522

# Macromolecular_Interacting_Partner_29_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_29_Locus:
7p13

# Macromolecular_Interacting_Partner_29_SNPs:
rs217435; rs10264715; rs2072183; rs217434; rs4724306; rs3187907; rs217436; rs217420; rs7798185; rs217415; rs217419; rs4720470; rs217418; rs217430; rs10272471; rs217432; rs217408; rs217429; rs217403; rs11767718; rs217421; rs217410; rs217414; rs11763759; rs217433; rs190059; rs2301935; rs217405; rs217431; rs217406; rs6973876; rs217426; rs217407; rs17711952; rs7808003; rs7808295; rs6955649; rs7792961; rs217416; rs2073547; rs17655652; rs17725246; rs2073548; rs35803101; rs7799582; rs1468384; rs7782372; rs7799594; rs41279633; rs41279627; rs217427; rs511711; rs41279630; rs9638975; rs34844396; rs34495280; rs217428; rs217404; rs34127174; rs34925061; rs511717; rs34651476; rs217423; rs10551210; rs10566482; rs217422; rs12667574; rs13226820; rs7793129; rs217409; rs35716484; rs35349497; rs7799467; rs217424; rs34307616; rs217412; rs217413; rs35235378; rs217417; rs10273356; rs217425; rs36070322; rs10554932; rs217411; rs34312374; rs35796481; rs34938373; rs34716309; rs35171483; rs34415328; rs17132982; rs35030053; rs10252732; rs10260606; rs10264622; rs13226024; rs17132552; rs17132561; rs1859592; rs217437; rs217438; rs217440; rs6954481; rs6974778

# Macromolecular_Interacting_Partner_29_General_References:
10783261

# Macromolecular_Interacting_Partner_29_References:
17008555; 17008586; 17058264; 17114806

# Macromolecular_Interacting_Partner_30_ID:
8556

# Macromolecular_Interacting_Partner_30_Name:
StAR-related lipid transfer protein 3

# Macromolecular_Interacting_Partner_30_Synonyms:
StARD3; START domain- containing protein 3; Metastatic lymph node protein 64; Protein MLN 64; Protein CAB1

# Macromolecular_Interacting_Partner_30_Gene_Name:
STARD3

# Macromolecular_Interacting_Partner_30_Protein_Sequence:
>StARrelated lipid transfer protein 3
MSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFD
LLFISLLWIIELNTNTGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRH
WWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEE
ERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIR
QGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEV
ILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRY
LSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKGRLPRYLIH
QSLAATMFEFAFHLRQRISELGARA

# Macromolecular_Interacting_Partner_30_Number_of_Residues:
445

# Macromolecular_Interacting_Partner_30_Molecular_Weight:
50503

# Macromolecular_Interacting_Partner_30_Theoretical_pI:
8.55

# Macromolecular_Interacting_Partner_30_GO_Classification:
>>>
 Function:  transporter activity
Function:  lipid transporter activity
Function:  sterol transporter activity
Function:  cholesterol transporter activity
Function:  binding
Function:  steroid binding
Function:  cholesterol binding
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_30_General_Function:
Not Available

# Macromolecular_Interacting_Partner_30_Specific_Function:
Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain

# Macromolecular_Interacting_Partner_30_Pathway:
Not Available

# Macromolecular_Interacting_Partner_30_Reaction:
Not Available

# Macromolecular_Interacting_Partner_30_Pfam_Domain_Function:
PF01852:START

# Macromolecular_Interacting_Partner_30_Signals:
Not Available

# Macromolecular_Interacting_Partner_30_Transmembrane_Regions:
52-72
95-115
121-141
149-169

# Macromolecular_Interacting_Partner_30_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_30_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_30_GenBank_ID_Protein:
951279

# Macromolecular_Interacting_Partner_30_SwissProt_ID:
STAR3_HUMAN (Q14849)

# Macromolecular_Interacting_Partner_30_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_30_Genecard_id:
STARD3

# Macromolecular_Interacting_Partner_30_Geneatlas_id:
STARD3

# Macromolecular_Interacting_Partner_30_hgnc_id:
HGNC:17579

# Macromolecular_Interacting_Partner_30_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_30_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_30_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_30_Subcellular_Location:
Endosome; late endosome; late endosomal membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_30_Gene_Sequence:
>1338 bp
ATGAGCAAGCTGCCCAGGGAGCTGACCCGAGACTTGGAGCGCAGCCTGCCTGCCGTGGCC
TCCCTGGGCTCCTCACTGTCCCACAGCCAGAGCCTCTCCTCGCACCTCCTTCCGCCGCCT
GAGAAGCGAAGGGCCATCTCTGATGTCCGCCGCACCTTCTGTCTCTTCGTCACCTTCGAC
CTGCTCTTCATCTCCCTGCTCTGGATCATCGAACTGAATACCAACACAGGCATCCGTAAG
AACTTGGAGCAGGAGATCATCCAGTACAACTTTAAAACTTCCTTCTTCGACATCTTTGTC
CTGGCCTTCTTCCGCTTCTCTGGACTGCTCCTAGGCTATGCCGTGCTGCAGCTCCGGCAC
TGGTGGGTGATTGCGGTCACGACGCTGGTGTCCAGTGCATTCCTCATTGTCAAGGTCATC
CTCTCTGAGCTGCTCAGCAAAGGGGCATTTGGCTACCTGCTCCCCATCGTCTCTTTTGTC
CTCGCCTGGTTGGAGACCTGGTTCCTTGACTTCAAAGTCCTACCCCAGGAAGCTGAAGAG
GAGCGATGGTATCTTGCCGCCCAGGTTGCTGTTGCCCGTGGACCCCTGCTGTTCTCCGGT
GCTCTGTCCGAGGGACAGTTCTATTCACCCCCAGAATCCTTTGCAGGGTCTGACAATGAA
TCAGATGAAGAAGTTGCTGGGAAGAAAAGTTTCTCTGCTCAGGAGCGGGAGTACATCCGC
CAGGGGAAGGAGGCCACGGCAGTGGTGGACCAGATCTTGGCCCAGGAAGAGAACTGGAAG
TTTGAGAAGAATAATGAATATGGGGACACCGTGTACACCATTGAAGTTCCCTTTCACGGC
AAGACGTTTATCCTGAAGACCTTCCTGCCCTGTCCTGCGGAGCTCGTGTACCAGGAGGTG
ATCCTGCAGCCCGAGAGGATGGTGCTGTGGAACAAGACAGTGACTGCCTGCCAGATCCTG
CAGCGAGTGGAAGACAACACCCTCATCTCCTATGACGTGTCTGCAGGGGCTGCGGGCGGC
GTGGTCTCCCCAAGGGACTTCGTGAATGTCCGGCGCATTGAGCGGCGCAGGGACCGATAC
TTGTCATCAGGGATCGCCACCTCACACAGTGCCAAGCCCCCGACGCACAAATATGTCCGG
GGAGAGAATGGCCCTGGGGGCTTCATCGTGCTCAAGTCGGCCAGTAACCCCCGTGTTTGC
ACCTTTGTCTGGATTCTTAATACAGATCTCAAGGGCCGCCTGCCCCGGTACCTCATCCAC
CAGAGCCTCGCGGCCACCATGTTTGAATTTGCCTTTCACCTGCGACAGCGCATCAGCGAG
CTGGGGGCCCGGGCGTGA

# Macromolecular_Interacting_Partner_30_GenBank_ID_Gene:
X80198

# Macromolecular_Interacting_Partner_30_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_30_Locus:
17q11-q12

# Macromolecular_Interacting_Partner_30_SNPs:
rs1877031; rs2941513; rs2941515; rs1874224; rs9892427; rs9972882; rs2132140; rs9913626; rs12103674; rs2934961; rs12937003; rs15968; rs9896679; rs3817160; rs881844; rs2271308; rs2952149; rs11869286; rs11658786; rs2952150; rs3794710; rs2941512; rs11556625; rs11556624; rs35673246; rs35874339; rs34408242; rs36015615; rs34282352; rs35201559; rs36006473; rs36076022; rs3794711; rs427103; rs10713558; rs7224588; rs8066399; rs28498326; rs35693151; rs1050293; rs5820301; rs4794817; rs4490035; rs2665646; rs34916052; rs11556623; rs35138184; rs34695955; rs28613091; rs35361174; rs9890115; rs9989476; rs35121075; rs2934959; rs5820302; rs3029514; rs35823125; rs34837428; rs2941514; rs2952139; rs34352266; rs35978659; rs7223964; rs9908580; rs2934960; rs2941516; rs2934958; rs35653322; rs7503843; rs1050321; rs1053651; rs1107794; rs11651497; rs12601930; rs14050; rs1495099; rs1874225; rs200173; rs2247862; rs2643192; rs2934963; rs2934966; rs2941503; rs2941510; rs2941511; rs2941523; rs2952151; rs3152; rs33932099; rs34257414; rs34341496; rs34719599; rs34773471; rs35751045; rs35821333; rs3751903; rs3764352; rs3764353; rs380503; rs3816935; rs392741; rs407307; rs4344777; rs5638; rs5639; rs5640; rs5641; rs5642; rs5643; rs5644; rs7212852; rs734645; rs876493; rs903502; rs907087; rs907094; rs931992; rs9532

# Macromolecular_Interacting_Partner_30_General_References:
7490069; 9270027; 10802740; 11053434

# Macromolecular_Interacting_Partner_30_References:
Not Available

# Macromolecular_Interacting_Partner_31_ID:
8718

# Macromolecular_Interacting_Partner_31_Name:
CDNA FLJ33567 fis, clone BRAMY2010272, highly similar to Homo sapiens cholesterol 24-hydroxylase mRNA

# Macromolecular_Interacting_Partner_31_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_31_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_31_Protein_Sequence:
>CDNA FLJ33567 fis, clone BRAMY2010272, highly similar to Homo sapiens cholesterol 24hydroxylase m
RNAMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKP
LSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEE
VPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQA
EVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGFSTYVMGR
MDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF
RLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC

# Macromolecular_Interacting_Partner_31_Number_of_Residues:
337

# Macromolecular_Interacting_Partner_31_Molecular_Weight:
38316

# Macromolecular_Interacting_Partner_31_Theoretical_pI:
5.90

# Macromolecular_Interacting_Partner_31_GO_Classification:
>>>
 Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_31_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Macromolecular_Interacting_Partner_31_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_31_Pathway:
Not Available

# Macromolecular_Interacting_Partner_31_Reaction:
Not Available

# Macromolecular_Interacting_Partner_31_Pfam_Domain_Function:
PF00067:p450

# Macromolecular_Interacting_Partner_31_Signals:
Not Available

# Macromolecular_Interacting_Partner_31_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_31_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_31_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_31_GenBank_ID_Protein:
21749132

# Macromolecular_Interacting_Partner_31_SwissProt_ID:
Q8N2B0_HUMAN (Q8N2B0)

# Macromolecular_Interacting_Partner_31_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_31_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_31_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_31_hgnc_id:
HGNC:2641

# Macromolecular_Interacting_Partner_31_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_31_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_31_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_31_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_31_Gene_Sequence:
>1014 bp
ATGGAAACATTCAACGAGAAGGCTGAGCAGCTGGTGGAGATTCTAGAAGCCAAGGCAGAT
GGGCAGACCCCAGTGTCCATGCAGGACATGCTGACCTACACCGCCATGGACATCCTGGCC
AAGGCAGCTTTTGGGATGGAGACCAGTATGCTGCTGGGTGCCCAGAAGCCTCTGTCCCAG
GCAGTGAAACTTATGTTGGAGGGAATCACTGCGTCCCGCAACACTCTGGCAAAGTTCCTG
CCAGGGAAGAGGAAGCAGCTCCGGGAGGTCCGGGAGAGCATTCGCTTCCTGCGCCAGGTG
GGCAGGGACTGGGTCCAGCGCCGCCGGGAAGCCCTGAAGAGGGGCGAGGAGGTTCCTGCC
GACATCCTCACACAGATTCTGAAAGCTGAAGAGGGAGCCCAGGACGACGAGGGTCTGCTG
GACAACTTCGTCACCTTCTTCATTGCTGGTCACGAGACCTCTGCCAACCACTTGGCGTTC
ACAGTGATGGAGCTGTCTCGCCAGCCAGAGATCGTGGCAAGGCTGCAGGCCGAGGTGGAT
GAGGTCATTGGTTCTAAGAGGTACCTGGATTTCGAGGACCTGGGGAGACTGCAGTACCTG
TCCCAGGTCCTCAAAGAGTCGCTGAGGCTGTACCCACCAGCATGGGGCACCTTTCGCCTG
CTGGAAGAGGAGACCTTGATTGATGGGTTCAGCACCTATGTCATGGGGCGGATGGACACA
TACTTTGAGGACCCGCTGACTTTCAACCCCGATCGCTTCGGCCCTGGAGCACCCAAGCCA
CGGTTCACCTACTTCCCCTTCTCCCTGGGCCACCGCTCCTGCATCGGGCAGCAGTTTGCT
CAGATGGAGGTGAAGGTGGTCATGGCAAAGCTGCTGCAGAGGCTGGAGTTCCGGCTGGTG
CCCGGGCAGCGCTTCGGGCTGCAGGAGCAGGCCACACTCAAGCCACTGGACCCCGTGCTG
TGCACCCTGCGGCCCCGCGGCTGGCAGCCCGCACCCCCACCACCCCCCTGCTGA

# Macromolecular_Interacting_Partner_31_GenBank_ID_Gene:
AK090886

# Macromolecular_Interacting_Partner_31_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_31_Locus:
Not Available

# Macromolecular_Interacting_Partner_31_SNPs:
Not Available

# Macromolecular_Interacting_Partner_31_General_References:
Not Available

# Macromolecular_Interacting_Partner_31_References:
Not Available

End of HMDB00067

Beginning of HMDB00068
# Accession_No:
HMDB00068

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-22 12:05:25

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Epinephrine

# Description:
Epinephrine is a catecholamine, a sympathomimetic monoamine derived from the amino acids phenylalanine and tyrosine.  It is the active sympathomimetic hormone secreted from the adrenal medulla in most species. It stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels. It is used in asthma and cardiac failure and to delay absorption of local anesthetics. Epinephrine also constricts arterioles in the skin and gut while dilating arterioles in leg muscles. It elevates the blood sugar level by increasing hydrolysis of glycogen to glucose in the liver, and at the same time begins the breakdown of lipids in adipocytes. Epinephrine has a suppressive effect on the immune system.

# Synonyms:
(-)-(R)-Epinephrine; (-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol; (-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol; (-)-Adrenaline; (-)-Epinephrine; (R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol; (R)-Adrenaline; (R)-Epinephrine; 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol; Adnephrine; Adrenal; Adrenalin; Adrenaline; Adrenine; Adrin; Ana-Kit; Bosmin; Bronkaid Mist; Chelafrin; Epifrin; Epiglaufrin; Epinefrina; Epinephran; Epinephrine; Epipen; Epirenan; Eppy; Exadrin; Glauposine; Hemisine; Hemostasin; Hemostatin; Hypernephrin; Isoptoepinal; L-Adrenaline; L-Methylaminoethanolcatechol; Levoepinephrine; Levorenen; Levorenin; Levorenine; Levoreninum; Lyodrin; Methylarterenol; Mucidrina; Nephridine; Nieraline; Paranephrin; Primatene Mist; R-(-)-Epinephrine; Renaglandin; Renaleptine; Renalina; Renoform; Renostypticin; Renostyptin; Scurenaline; Simplene; Styptirenal; Supracapsulin; Supranephrane; Suprarenaline; Suprarenin; Surrenine; Sus-phrine; Takamina; Vasoconstrictine; Vasotonin; l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol; l-Epinephrine; l-Epirenamine; (-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol; (-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol

# Chemical_IUPAC_Name:
4-[(1R)-1-hydroxy-2-methylamino-ethyl]benzene-1,2-diol

# Chemical_Formula:
C9H13NO3

# Chemical_Structure:
tbl_chemical:::HMDB00068_ZOOM.png:::119283171005840268

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00068_THUMB.png:::11928317081276558

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Catecholamines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
secondary alcohol; 1,2-aminoalcohol; phenol or hydroxyhetarene; 1,2-diphenol; secondary amine; secondary aliphatic amine (dialkylamine); aromatic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
183.08954

# Molecular_Weight_Avg:
183.20442

# Smiles_String_isomeric:
CNC[C@H](O)C1=CC=C(O)C(O)=C1

# Smiles_String_canonical:
CNCC(O)C1=CC=C(O)C(O)=C1

# KEGG_Compound_ID:
C00788

# BioCyc_ID:
L-EPINEPHRINE

# PubChem_CID:
5816

# PubChem_SID:
8144253; 7854082; 3138582; 7849617; 4046; 219191; 7979175; 8153586; 7847163; 148608; 11111154

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
35997

# Wikipedia_ID:
Epinephrine

# METLIN_ID:
5127

# Ref_ID:
16705573; 9626157; 9384611; 15300253; 9269942; 12851650; 2159374; 9327880; 10556286; 11642745; 15579180; 12649306; 16777916; 1347802; 7704967; 12834252; 16840834; 7769131; 9931050; 10349032

# ChEBI_ID:
28918

# CAS_Registry_Number:
51-43-4

# InChI:
InChI=1/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1

# Synthesis_Reference:
 Tetrahedron Letters  (1997),  38(6),  927-930.

# Melting_Point:
211.5 oC

# Melting_Point_predicted:
104.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.18 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
18.6 mg/mL [Predicted by ALOGPS]

# phys_charge:
1

# State:
Solid

# LogP:
-1.37 [HANSCH,C & LEO,AJ (1985)]

# LogP_predicted:
-0.81 [Predicted by ALOGPS]; 0.256 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00788.mol:::1132723804875615621

# SDF_File_[Text]:
tbl_chemical:::HMDB00068.sdf:::119283170452799092

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00068.pdb:::119283170674937846

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::51-43-4p-presat_JM.GIF:::1133818453910503357

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041016_P00_01_HW_1DP_presat.zip:::114865624140440147

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041016_P00_01_HW_1DP_Assigned.png:::115636681337374347

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041016_P00_01_HW_2DHSQC_789.png:::114805881030263873

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041016_P00_01_HW_2DHSQC_789.zip:::114805881030779371

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041016_P00_01_HW_2DHSQC_789_Assigned.png:::115333716999837913

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Epinephrine.gif:::1132732105093748658

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00068_peaks.txt:::115630952453971015

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Epinephrine_C.gif:::1132737674351146879

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00068_peaks.txt:::1156310714948286861

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00068L.png:::117555262358863027; Medium Energy:tbl_ms:::HMDB00068M.png:::117555267733526234; High Energy:tbl_ms:::HMDB00068H.png:::117555271313129583

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; Extracellular

# Tissue_Location:
Adipose Tissue; Adrenal Cortex; Adrenal Gland; Adrenal Medulla; Bladder; Epidermis; Eye Lens; Fibroblasts; Gonads; Gut; Intestine; Kidney; Kidney (Adrenal Medulla); Liver; Muscle; Myelin; Nerves; Nervous Tissues; Neurons; Pancreas; Placenta; Platelet; Pro

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	0.002 +/- 0.00099	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	10349032
Urine	0.0052 (0.00043-0.0099)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9931050
Blood	0.00072 (0.00049-0.0013)	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	0.0003(0.00027-0.00033)	umol/L	Adult:>18_yrs_old	Both	Normal	7704967
Cerebrospinal_Fluid(CSF)	0.0(0.0-0.00022)	umol/L	Adult:>18_yrs_old	Both	Normal	15123562
Cerebrospinal_Fluid(CSF)	0.034 (0.0063-0.062)	umol/L	Adult:>18_yrs_old	Female	Normal	12834252
Cerebrospinal_Fluid(CSF)	0.00024	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.


# Concentration_[Abnormal]:
Blood	0.00014 (0.0001-0.00017)	umol/L	Adult:>18_yrs_old	Both	Addison's disease	7704967
Blood	0.00031	umol/L	Adult:>18_yrs_old	Both	Pheochromocytoma	9626157


# Associated_Disorders:
Addison's disease; Cardiac Arrhythmias; Cerebral Hemorrhage; Long QT Syndrome; Obesity; Palpitations; Pheochromocytoma; Renal Cancer; Restlessness; Throbbing Headache; Tremor

# Pathway_Names:
Tyrosine metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00350

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5393

# Metabolic_Enzyme_1_Name:
Amine oxidase [flavin-containing] B

# Metabolic_Enzyme_1_Synonyms:
Monoamine oxidase type B; MAO-B

# Metabolic_Enzyme_1_Gene_Name:
MAOB

# Metabolic_Enzyme_1_Protein_Sequence:
>Amine oxidase flavincontaining 
BMSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGS
YVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFW
RTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHE
VSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYID
QTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIV
YYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEE
RLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVD
RIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITT
TFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV

# Metabolic_Enzyme_1_Number_of_Residues:
520

# Metabolic_Enzyme_1_Molecular_Weight:
58764

# Metabolic_Enzyme_1_Theoretical_pI:
7.55

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine

# Metabolic_Enzyme_1_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_1_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01593:Amino_oxidase

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
490-516

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.4.3.4

# Metabolic_Enzyme_1_GenBank_ID_Protein:
398415

# Metabolic_Enzyme_1_SwissProt_ID:
AOFB_HUMAN (P27338)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
MAOB

# Metabolic_Enzyme_1_Geneatlas_id:
MAOB

# Metabolic_Enzyme_1_hgnc_id:
HGNC:6834

# Metabolic_Enzyme_1_PDB_ID:
2BK3

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type IV membrane protein; cytoplasmic side

# Metabolic_Enzyme_1_Gene_Sequence:
>1560 bp
ATGAGCAACAAATGCGACGTGGTCGTGGTGGGGGGCGGCATCTCAGGTATGGCAGCAGCC
AAACTTCTGCATGACTCTGGACTGAATGTGGTTGTTCTGGAAGCCCGGGACCGTGTGGGA
GGCAGGACTTACACTCTTAGGAACCAAAAGGTTAAATATGTGGACCTTGGAGGATCCTAT
GTTGGACCAACCCAGAATCGTATCTTGAGATTAGCCAAGGAGCTAGGATTGGAGACCTAC
AAAGTGAATGAGGTTGAGCGTCTGATCCACCATGTAAAGGGCAAATCATACCCCTTCAGG
GGGCCATTCCCACCTGTATGGAATCCAATTACCTACTTAGATCATAACAACTTTTGGAGG
ACAATGGATGACATGGGGCGAGAGATTCCGAGTGATGCCCCATGGAAGGCTCCCCTTGCA
GAAGAGTGGGACAACATGACAATGAAGGAGCTACTGGACAAGCTCTGCTGGACTGAATCT
GCAAAGCAGCTTGCCACTCTCTTTGTGAACCTGTGTGTCACTGCAGAGACCCATGAGGTC
TCTGCTCTCTGGTTCCTGTGGTATGTGAAGCAGTGTGGAGGCACAACAAGAATCATCTCG
ACAACAAATGGAGGACAGGAGAGGAAATTTGTGGGCGGATCTGGTCAAGTGAGTGAGCGG
ATAATGGACCTCCTTGGAGACCGAGTGAAGCTGGAGAGGCCTGTGATCTACATTGACCAG
ACAAGAGAAAATGTCCTTGTGGAGACCCTAAACCATGAGATGTATGAGGCTAAATATGTG
ATTAGTGCTATTCCTCCTACTCTGGGCATGAAGATTCACTTCAATCCCCCTCTGCCAATG
ATGAGAAACCAGATGATCACTCGTGTGCCTTTGGGTTCAGTCATCAAGTGTATAGTTTAT
TATAAAGAGCCTTTCTGGAGGAAAAAGGATTACTGTGGAACCATGATTATTGATGGAGAA
GAAGCTCCAGTTGCCTACACGTTGGATGATACCAAACCTGAAGGCAACTATGCTGCCATA
ATGGGATTTATCCTGGCCCACAAAGCCAGAAAACTGGCACGTCTTACCAAAGAGGAAAGG
TTGAAGAAACTTTGTGAACTCTATGCCAAGGTTCTGGGTTCCCTAGAAGCTCTGGAGCCA
GTGCATTATGAAGAAAAGAACTGGTGTGAGGAGCAGTACTCTGGGGGCTGCTACACAACT
TATTTCCCCCCTGGGATCCTGACTCAATATGGAAGGGTTCTACGCCAGCCAGTGGACAGG
ATTTACTTTGCAGGCACCGAGACTGCCACACACTGGAGCGGCTACATGGAGGGGGCTGTA
GAGGCCGGGGAGAGAGCAGCCCGAGAGATCCTGCATGCCATGGGGAAGATTCCAGAGGAT
GAAATCTGGCAGTCAGAACCAGAGTCTGTGGATGTCCCTGCACAGCCCATCACCACCACC
TTTTTGGAGAGACATTTGCCCTCCGTGCCAGGCCTGCTCAGGCTGATTGGATTGACCACC
ATCTTTTCAGCAACGGCTCTTGGCTTCCTGGCCCACAAAAGGGGGCTACTTGTGAGAGTC


# Metabolic_Enzyme_1_GenBank_ID_Gene:
S62734

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_1_Locus:
Xp11.23

# Metabolic_Enzyme_1_SNPs:
rs7879356; rs6324; rs12010260; rs2072745; rs17462; rs3027440; rs7066677; rs3027439; rs1799836; rs3027453; rs2311013; rs3027441; rs5905512; rs3027459; rs2239450; rs2239441; rs7890174; rs5952297; rs3027444; rs5952330; rs7883073; rs5952671; rs6520902; rs2239449; rs6651806; rs3027454; rs7057075; rs12394221; rs2238969; rs12008119; rs7888450; rs12388038; rs2283727; rs12013965; rs17310637; rs12008438; rs5952294; rs5952340; rs12008548; rs12014398; rs1014876; rs3027449; rs2283730; rs2283729; rs5952813; rs6520901; rs5952352; rs2205655; rs10521432; rs6610856; rs12006628; rs3027450; rs6610853; rs2283731; rs3027456; rs2283728; rs9887326; rs5952325; rs3027442; rs7879586; rs12389168; rs3817729; rs12851487; rs5952686; rs3736672; rs2056913; rs1569424; rs7053203; rs2092042; rs7876594; rs12010996; rs3027457; rs9887047; rs3027451; rs17146716; rs7061798; rs3027464; rs6609259; rs3027446; rs736944; rs2239442; rs6609260; rs7067187; rs3027466; rs12558324; rs7888462; rs3027452; rs2092040; rs4824562; rs17146721; rs7884044; rs3027461; rs12389234; rs12007768; rs17244906; rs5952795; rs17146719; rs5905449; rs5952799; rs12394863; rs3027458; rs3027443; rs9698576; rs2092041; rs7892217; rs7061088; rs12689868; rs7067027; rs3027448; rs12558614; rs7057957; rs1040398; rs1040400; rs3027435; rs1181252; rs1040399; rs3027434; rs17852046; rs12850496; rs12845773; rs17856663; rs12845783; rs5952696; rs3191382; rs1181251; rs35285191; rs1051000; rs1803940; rs3027438; rs1051003; rs1050990; rs4339787; rs28530533; rs3027468; rs5952754; rs5952690; rs12558961; rs12852985; rs34468176; rs2311012; rs5905428; rs34165496; rs34825602; rs7892394; rs5952812; rs11091124; rs5906017; rs28522648; rs5952677; rs11282093; rs5906045; rs3838196; rs3027455; rs28667959; rs3027463; rs35676271; rs12841775; rs35574902; rs3027447; rs28657720; rs6610848; rs28531879; rs4824563; rs6610854; rs7060566; rs12396954; rs3027469; rs35687186; rs5952736; rs35375952; rs7057164; rs34716997; rs7062993; rs7063171; rs11412800; rs6651629; rs12845848; rs12853563; rs12012179; rs28368734; rs12115950; rs35968321; rs3027460; rs12394356; rs35439218; rs36085366; rs34265248; rs35762562; rs2239451; rs34292051; rs3027445; rs11320541; rs10481834; rs12845568; rs4592179; rs3216388; rs34945383; rs34220802; rs6610855; rs34261731; rs28485908; rs7888867; rs11431011; rs4071606; rs12390352; rs10567219; rs35520175; rs28527225; rs36068670; rs5952687; rs7888857; rs5952777; rs34822523; rs12010683; rs7883563; rs5952814; rs36209687; rs5952751; rs2238970; rs5952744; rs35797631; rs12389578; rs7474005; rs3027465; rs5952768; rs5906031; rs28636832; rs34252524; rs7058426; rs12391346; rs12689072; rs35943983; rs12395246; rs11414517; rs3027467; rs12013925; rs3736671; rs28421767; rs7058949; rs35634965; rs28754429; rs1894610; rs36102775; rs9887081; rs5952817; rs12855578; rs10658111; rs7062575; rs4620438; rs28568938; rs35291347; rs11797733; rs35054600; rs5952335; rs3027462; rs5952712; rs34752122; rs3054011; rs3027437; rs28577261; rs3027433; rs3761584; rs3027436; rs3027432; rs12558036; rs3027418; rs3027419; rs3027420; rs3027421; rs3027423; rs3027424; rs3027425; rs3027426; rs3027427; rs3027428; rs3027429; rs3027430; rs3027431; rs4351544; rs7884135; rs7890899

# Metabolic_Enzyme_1_General_References:
2023912; 3387449; 8515265; 1432104; 11049757; 11753429

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5643

# Metabolic_Enzyme_2_Name:
Phenylethanolamine N-methyltransferase

# Metabolic_Enzyme_2_Synonyms:
PNMTase; Noradrenaline N-methyltransferase

# Metabolic_Enzyme_2_Gene_Name:
PNMT

# Metabolic_Enzyme_2_Protein_Sequence:
>Phenylethanolamine Nmethyltransferase
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL

# Metabolic_Enzyme_2_Number_of_Residues:
282

# Metabolic_Enzyme_2_Molecular_Weight:
30855

# Metabolic_Enzyme_2_Theoretical_pI:
5.96

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Converts noradrenaline to adrenaline

# Metabolic_Enzyme_2_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_2_Reaction:
S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01234:NNMT_PNMT_TEMT

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.1.1.28

# Metabolic_Enzyme_2_GenBank_ID_Protein:
190142

# Metabolic_Enzyme_2_SwissProt_ID:
PNMT_HUMAN (P11086)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
PNMT

# Metabolic_Enzyme_2_Geneatlas_id:
PNMT

# Metabolic_Enzyme_2_hgnc_id:
HGNC:9160

# Metabolic_Enzyme_2_PDB_ID:
1N7J

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>849 bp
ATGAGCGGCGCAGACCGTAGCCCCAATGCGGGCGCAGCCCCTGACTCGGCCCCGGGCCAG
GCGGCGGTGGCTTCGGCCTACCAGCGCTTCGAGCCGCGCGCCTACCTCCGCAACAACTAC
GCGCCCCCTCGCGGGGACCTGTGCAACCCGAACGGCGTCGGGCCGTGGAAGCTGCGCTGC
TTGGCGCAGACCTTCGCCACCGGTGAAGTGTCCGGACGCACCCTCATCGACATTGGTTCA
GGCCCCACCGTGTACCAGCTGCTCAGTGCCTGCAGCCACTTTGAGGACATCACCATGACA
GATTTCCTGGAGGTCAACCGCCAGGAGCTGGGGCGCTGGCTGCAGGAGGAGCCGGGGGCC
TTCAACTGGAGCATGTACAGCCAACATGCCTGCCTCATTGAGGGCAAGGGGGAATGCTGG
CAGGATAAGGAGCGCCAGCTGCGAGCCAGGGTGAAACGGGTCCTGCCCATCGACGTGCAC
CAGCCCCAGCCCCTGGGTGCTGGGAGCCCAGCTCCCCTGCCTGCTGACGCCCTGGTCTCT
GCCTTCTGCTTGGAGGCTGTGAGCCCAGATCTTGCCAGCTTTCAGCGGGCCCTGGACCAC
ATCACCACGCTGCTGAGGCCTGGGGGGCACCTCCTCCTCATCGGGGCCCTGGAGGAGTCG
TGGTACCTGGCTGGGGAGGCCAGGCTGACGGTGGTGCCAGTGTCTGAGGAGGAGGTGAGG
GAGGCCCTGGTGCGTAGTGGCTACAAGGTCCGGGACCTCCGCACCTATATCATGCCTGCC
CACCTTCAGACAGGCGTAGATGATGTCAAGGGCGTCTTCTTCGCCTGGGCTCAGAAGGTT
GGGCTGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
J03727

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_2_Locus:
17q21-q22

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
3372503; 2835776

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5401

# Metabolic_Enzyme_3_Name:
Amine oxidase [flavin-containing] A

# Metabolic_Enzyme_3_Synonyms:
Monoamine oxidase type A; MAO-A

# Metabolic_Enzyme_3_Gene_Name:
MAOA

# Metabolic_Enzyme_3_Protein_Sequence:
>Amine oxidase flavincontaining 
AMENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEH
VDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPI
AYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVN
INVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVK
LNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLP
MGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKAD
RLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQY
GRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESK
DVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS

# Metabolic_Enzyme_3_Number_of_Residues:
527

# Metabolic_Enzyme_3_Molecular_Weight:
59682

# Metabolic_Enzyme_3_Theoretical_pI:
7.96

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine

# Metabolic_Enzyme_3_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_3_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01593:Amino_oxidase

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
498-518

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.4.3.4

# Metabolic_Enzyme_3_GenBank_ID_Protein:
187353

# Metabolic_Enzyme_3_SwissProt_ID:
AOFA_HUMAN (P21397)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
MAOA

# Metabolic_Enzyme_3_Geneatlas_id:
MAOA

# Metabolic_Enzyme_3_hgnc_id:
HGNC:6833

# Metabolic_Enzyme_3_PDB_ID:
1O5W

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type IV membrane protein; cytoplasmic side

# Metabolic_Enzyme_3_Gene_Sequence:
>1584 bp
ATGGAGAATCAAGAGAAGGCGAGTATCGCGGGCCACATGTTCGACGTAGTCGTGATCGGA
GGTGGCATTTCAGGACTATCTGCTGCCAAACTCTTGACTGAATATGGCGTTAGTGTTTTG
GTTTTAGAAGCTCGGGACAGGGTTGGAGGAAGAACATATACTATAAGGAATGAGCATGTT
GATTACGTAGATGTTGGTGGAGCTTATGTGGGACCAACCCAAAACAGAATCTTACGCTTG
TCTAAGGAGCTGGGCATAGAGACTTACAAAGTGAATGTCAGTGAGCGTCTCGTTCAATAT
GTCAAGGGGAAAACATATCCATTTCGGGGCGCCTTTCCACCAGTATGGAATCCCATTGCA
TATTTGGATTACAATAATCTGTGGAGGACAATAGATAACATGGGGAAGGAGATTCCAACT
GATGCACCCTGGGAGGCTCAACATGCTGACAAATGGGACAAAATGACCATGAAAGAGCTC
ATTGACAAAATCTGCTGGACAAAGACTGCTAGGCGGTTTGCTTATCTTTTTGTGAATATC
AATGTGACCTCTGAGCCTCACGAAGTGTCTGCCCTGTGGTTCTTGTGGTATGTGAAGCAG
TGCGGGGGCACCACTCGGATATTCTCTGTCACCAATGGTGGCCAGGAACGGAAGTTTGTA
GGTGGATCTGGTCAAGTGAGCGAACGGATAATGGACCTCCTCGGAGACCAAGTGAAGCTG
AACCATCCTGTCACTCACGTTGACCAGTCAAGTGACAACATCATCATAGAGACGCTGAAC
CATGAACATTATGAGTGCAAATACGTAATTAATGCGATCCCTCCGACCTTGACTGCCAAG
ATTCACTTCAGACCAGAGCTTCCAGCAGAGAGAAACCAGTTAATTCAGCGGCTTCCAATG
GGAGCTGTCATTAAGTGCATGATGTATTACAAGGAGGCCTTCTGGAAGAAGAAGGATTAC
TGTGGCTGCATGATCATTGAAGATGAAGATGCTCCAATTTCAATAACCTTGGATGACACC
AAGCCTGATGGGTCACTGCCTGCCATCATGGGCTTCATTCTTGCCCGGAAAGCTGATCGA
CTTGCTAAGCTACATAAGGAAATAAGGAAGAAGAAAATCTGTGAGCTCTATGCCAAAGTG
CTGGGATCCCAAGAAGCTTTACATCCAGTGCATTATGAAGAGAAGAACTGGTGTGAGGAG
CAGTACTCTGGGGGCTGCTACACGGCCTACTTCCCTCCTGGGATCATGACTCAATATGGA
AGGGTGATTCGTCAACCCGTGGGCAGGATTTTCTTTGCGGGCACAGAGACTGCCACAAAG
TGGAGCGGCTACATGGAAGGGGCAGTTGAGGCTGGAGAACGAGCAGCTAGGGAGGTCTTA
AATGGTCTCGGGAAGGTGACCGAGAAAGATATCTGGGTACAAGAACCTGAATCAAAGGAC
GTTCCAGCGGTAGAAATCACCCACACCTTCTGGGAAAGGAACCTGCCCTCTGTTTCTGGC
CTGCTGAAGATCATTGGATTTTCCACATCAGTAACTGCCCTGGGGTTTGTGCTGTACAAA
TACAAGCTCCTGCCACGGTCTTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M68840

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_3_Locus:
Xp11.3

# Metabolic_Enzyme_3_SNPs:
rs6323; rs1137070; rs1800464; rs3027407; rs2072743; rs1465107; rs979605; rs3027397; rs2205718; rs979606; rs909525; rs3788862; rs2283725; rs2235186; rs5906883; rs5906974; rs3027403; rs3027405; rs6520894; rs3027401; rs3788863; rs2235185; rs1465108; rs5953385; rs2310883; rs6609250; rs3027398; rs5906938; rs5906729; rs6520897; rs5906893; rs17146683; rs7885398; rs3027402; rs5905702; rs5906957; rs2072744; rs5906915; rs4824498; rs9723729; rs3027406; rs5906973; rs3027400; rs2064697; rs5906914; rs5906901; rs12689575; rs2239448; rs2064696; rs3027392; rs2238968; rs17146660; rs12688067; rs9723711; rs7051042; rs5905859; rs7887158; rs2064698; rs7882699; rs3027399; rs9330645; rs2283724; rs9723795; rs3027404; rs9724332; rs5953210; rs1803986; rs1799835; rs1800466; rs1803987; rs1800465; rs7065428; rs3027408; rs11544798; rs12839550; rs10545588; rs5952250; rs3027394; rs34390290; rs1800659; rs10560402; rs12854463; rs35759188; rs28375424; rs7059300; rs12687961; rs35784967; rs35254233; rs34894015; rs35215664; rs35546327; rs3027396; rs12556694; rs7057038; rs12687974; rs9780693; rs7892282; rs5902323; rs28593700; rs35600375; rs35488042; rs35200424; rs5902326; rs5905823; rs12843650; rs34941362; rs34841794; rs12833632; rs12863636; rs3030071; rs12398290; rs10548364; rs28401570; rs4604608; rs28449781; rs6609256; rs6610845; rs12833929; rs12843268; rs2310884; rs5905830; rs6610846; rs7054032; rs7880230; rs41303697; rs3810709; rs2179098; rs12399572; rs12840448; rs5902324; rs28556796; rs5905812; rs12847449; rs28619059; rs10652560; rs6610837; rs10548363; rs5905418; rs2283726; rs33910552; rs3027395; rs28637527; rs5906971; rs28439389; rs35235270; rs3027393; rs28583596; rs6610842; rs6520893; rs35336176; rs5906913; rs12849959; rs36036121; rs5905822; rs5902325; rs5905809; rs11471949; rs6610834; rs3838195; rs3216387; rs33946653; rs6609255; rs35445276; rs7061874; rs17436054; rs1181275; rs12843533; rs2064070; rs3027409; rs3027410; rs3027414; rs3027415; rs3027416; rs3027417; rs4301558; rs4570308; rs5905613; rs6609257; rs6609258; rs7052785; rs727884

# Metabolic_Enzyme_3_General_References:
3418353; 3387449; 1432104; 8584674; 7519662; 3178846; 2764901; 11812236

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5504

# Metabolic_Enzyme_4_Name:
Catechol O-methyltransferase

# Metabolic_Enzyme_4_Synonyms:
Not Available

# Metabolic_Enzyme_4_Gene_Name:
COMT

# Metabolic_Enzyme_4_Protein_Sequence:
>Catechol Omethyltransferase
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRIL
NHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCG
YSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKY
DVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFE
CTHYQSFLEYREVVDGLEKAIYKGPGSEAGP

# Metabolic_Enzyme_4_Number_of_Residues:
271

# Metabolic_Enzyme_4_Molecular_Weight:
30037

# Metabolic_Enzyme_4_Theoretical_pI:
5.15

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  O-methyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol

# Metabolic_Enzyme_4_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_4_Reaction:
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01596:Methyltransf_3

# Metabolic_Enzyme_4_Signals:
1-32

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.1.1.6

# Metabolic_Enzyme_4_GenBank_ID_Protein:
180920

# Metabolic_Enzyme_4_SwissProt_ID:
COMT_HUMAN (P21964)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
COMT

# Metabolic_Enzyme_4_Geneatlas_id:
COMT

# Metabolic_Enzyme_4_hgnc_id:
HGNC:2228

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Isoform S-COMT:Cytoplasm. Isoform MB-COMT:Cell membrane; single-pass type II membrane protein; extracellular side

# Metabolic_Enzyme_4_Gene_Sequence:
>816 bp
ATGCCGGAGGCCCCGCCTCTGCTGTTGGCAGCTGTGTTGCTGGGCCTGGTGCTGCTGGTG
GTGCTGCTGCTGCTTCTGAGGCACTGGGGCTGGGGCCTGTGCCTTATCGGCTGGAACGAG
TTCATCCTGCAGCCCATCCACAACCTGCTCATGGGTGACACCAAGGAGCAGCGCATCCTG
AACCACGTGCTGCAGCATGCGGAGCCCGGGAACGCACAGAGCGTGCTGGAGGCCATTGAC
ACCTACTGCGAGCAGAAGGAGTGGGCCATGAACGTGGGCGACAAGAAAGGCAAGATCGTG
GACGCCGTGATTCAGGAGCACCAGCCCTCCGTGCTGCTGGAGCTGGGGGCCTACTGTGGC
TACTCAGCTGTGCGCATGGCCCGCCTGCTGTCACCAGGGGCGAGGCTCATCACCATCGAG
ATCAACCCCGACTGTGCCGCCATCACCCAGCGGATGGTGGATTTCGCTGGCGTGAAGGAC
AAGGTCACCCTTGTGGTTGGAGCGTCCCAGGACATCATCCCCCAGCTGAAGAAGAAGTAT
GATGTGGACACACTGGACATGGTCTTCCTCGACCACTGGAAGGACCGGTACCTGCCGGAC
ACGCTTCTCTTGGAGGAATGTGGCCTGCTGCGGAAGGGGACAGTGCTACTGGCTGACAAC
GTGATCTGCCCAGGTGCGCCAGACTTCCTAGCACACGTGCGCGGGAGCAGCTGCTTTGAG
TGCACACACTACCAATCGTTCCTGGAATACAGGGAGGTGGTGGACGGCCTGGAGAAGGCC
ATCTACAAGGGCCCAGGCAGCGAAGCAGGGCCCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M65212

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_4_Locus:
22q11.21-q11.23|22q11.21

# Metabolic_Enzyme_4_SNPs:
rs5031015; rs6267; rs4680; rs13306279; rs13306281; rs6270; rs740602; rs8192488; rs4818; rs769223; rs769224; rs165631; rs4633; rs6269; rs739368; rs165656; rs4646312; rs5992501; rs7287550; rs165722; rs5746849; rs11569715; rs740603; rs9332380; rs7290221; rs174674; rs9332351; rs3810595; rs174675; rs5993887; rs9332361; rs6518593; rs174680; rs9332356; rs5993882; rs11569716; rs3087869; rs9332325; rs174673; rs174678; rs5993883; rs933271; rs9332359; rs165767; rs9332347; rs8185002; rs5993879; rs9332363; rs174691; rs9332332; rs5992500; rs174682; rs9332346; rs13306280; rs362204; rs174688; rs9332342; rs11569717; rs174695; rs5993881; rs7291003; rs1544325; rs9332331; rs3819621; rs174684; rs34798238; rs174677; rs174690; rs9606196; rs174693; rs11912353; rs12053782; rs11913025; rs36111598; rs5993888; rs9332362; rs174685; rs34438295; rs5992499; rs34691071; rs9332357; rs174692; rs9332334; rs3838146; rs9332333; rs9332352; rs35014456; rs35527466; rs35558779; rs11704299; rs9332350; rs6268; rs34450201; rs9680656; rs1055503; rs11912354; rs11089323; rs5993884; rs16982842; rs174679; rs9332353; rs34300220; rs9332358; rs9332360; rs34937293; rs34966851; rs174676; rs16982844; rs5844402; rs9332323; rs35919169; rs174683; rs35777291; rs9332348; rs8140865; rs34686565; rs165737; rs4646315; rs2239393; rs165774; rs9306235; rs740601; rs5993889; rs9306234; rs4646316; rs8140835; rs4646317; rs9332370; rs174697; rs174696; rs9332377; rs4646318; rs1109436; rs9332368; rs3218737; rs34068292; rs9332369; rs9332364; rs9332372; rs9332367; rs9332365; rs4646313; rs34446512; rs34819182; rs174699; rs34234839; rs165895; rs165599; rs9332381; rs35478083; rs36082074; rs11544670; rs4986871; rs11544669; rs165879; rs35791904; rs35788262; rs13054814; rs5992498; rs5748490; rs361698; rs28600912; rs9605040; rs11703339; rs9332319; rs174689; rs9606193; rs5844403; rs9332340; rs34778315; rs11703340; rs5993886; rs14968; rs9332344; rs28621910; rs3081743; rs174681; rs361549; rs35280052; rs361708; rs12167365; rs2004497; rs12170804; rs35357972; rs9332321; rs361574; rs9332328; rs35920235; rs9332337; rs5993880; rs12814; rs9332343; rs11544667; rs9606195; rs9332349; rs11296030; rs5748492; rs9332354; rs34029447; rs35188675; rs3819619; rs8136901; rs35094299; rs9332322; rs28804429; rs174687; rs9332339; rs11912495; rs35617967; rs9332327; rs9332336; rs3841769; rs12167215; rs362253; rs9332338; rs35689277; rs11703069; rs174686; rs12168881; rs9606194; rs361699; rs9332355; rs3081741; rs5746850; rs9617852; rs28565095; rs13306277; rs174698; rs9332373; rs9332374; rs9332366; rs13054356; rs35819339; rs11460758; rs4646314; rs34016976; rs2904564; rs12158230; rs13055002; rs9332375; rs28562050; rs9332378; rs9332371; rs9332376; rs10427781; rs10427983; rs10483103; rs1110477; rs1110478; rs1110479; rs12165997; rs12169508; rs12627876; rs165655; rs165728; rs165815; rs165824; rs165840; rs165849; rs1800749; rs2020917; rs2073749; rs2239394; rs2239395; rs2240713; rs2240714; rs2240715; rs2240718; rs2518823; rs2518824; rs2871047; rs34134422; rs35219372; rs3788319; rs3788320; rs4646310; rs5746846; rs5746847; rs5748483; rs5748484; rs5993890; rs5993891; rs7288060; rs737864; rs737865; rs737866; rs758373; rs8140265; rs887199; rs887200; rs9265; rs9332314; rs9332315; rs9605030; rs9605031; rs9606186; rs9606189; rs9606201; rs9618716

# Metabolic_Enzyme_4_General_References:
1707278; 1847521; 8055944; 1993083; 1765063; 8807664; 10391209

# Metabolic_Enzyme_4_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7197

# Macromolecular_Interacting_Partner_1_Name:
Corticotropin-lipotropin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Pro-opiomelanocortin; POMC[Contains: NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin]

# Macromolecular_Interacting_Partner_1_Gene_Name:
POMC

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Corticotropinlipotropin precursor
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
267

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
29424

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Beta-endorphin and Met-enkephalin are endogenous opiates

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00976:ACTH_domain;
PF08384:NPP;
PF08035:Op_neuropeptide

# Macromolecular_Interacting_Partner_1_Signals:
1-26

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
190188

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
COLI_HUMAN (P01189)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
POMC

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
POMC

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9201

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>789 bp
TGCAGCCGCTCGGGGGCCCTGTTGCTGGCCTTGCTGCTTCAGGCCTCCATGGAAGTGCGT
GGCTGGTGCCTGGAGAGCAGCCAGTGTCAGGACCTCACCACGGAAAGCAACCTGCTGGAG
TGCATCCGGGCCTGCAAGCCCGACCTCTCGGCCGAGACTCCCATGTTCCCGGGAAATGGC
GACGAGCAGCCTCTGACCGAGAACCCCCGGAAGTACGTCATGGGCCACTTCCGCTGGGAC
CGATTCGGCCGCCGCAACAGCAGCAGCAGCGGCAGCAGCGGCGCAGGGCAGAAGCGCGAG
GACGTCTCAGCGGGCGAAGACTGCGGCCCGCTGCCTGAGGGCGGCCCCGAGCCCCGCAGC
GATGGTGCCAAGCCGGGCCCGCGCGAGGGCAAGCGCTCCTACTCCATGGAGCACTTCCGC
TGGGGCAAGCCGGTGGGCAAGAAGCGGCGCCCAGTGAAGGTGTACCCTAACGGCGCCGAG
GACGAGTCGGCCGAGGCCTTCCCCCTGGAGTTCAAGAGGGAGCTGACTGGCCAGCGACTC
CGGGAGGGAGATGGCCCCGACGGCCCTGCCGATGACGGCGCAGGGGCCCAGGCCGACCTG
GAGCACAGCCTGCTGGTGGCGGCCGAGAAGAAGGACGAGGGCCCCTACAGGATGGAGCAC
TTCCGCTGGGGCAGCCCGCCCAAGGACAAGCGCTACGGCGGTTTCATGACCTCCGAGAAG
AGCCAGACGCCCCTGGTGACGCTGTTCAAAAACGCCATCATCAAGAACGCCTACAAGAAG
GGCGAGTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M38297

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_1_Locus:
2p23.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs28932472; rs8192606; rs28932471; rs35254395; rs8192605; rs28930368; rs2071345; rs34650613; rs1042571; rs11679531; rs6713532; rs7565877; rs6713396; rs12473543; rs6756695; rs6545975; rs6756566; rs28932474; rs28932476; rs28932475; rs28932473; rs10654394; rs28932470; rs3039380; rs35411223; rs35023083; rs33950052; rs7591899; rs15461; rs2071344; rs13388660; rs9973478; rs11353932; rs13404336; rs7565427; rs34619618; rs8192607; rs35639116; rs34526166; rs10188864; rs10195561; rs11892647; rs12472851; rs13418937; rs17046887; rs17046891; rs1866146; rs2071343; rs2118404; rs2164808; rs3769671; rs3795955; rs3820935; rs6545976; rs6719226; rs6734859; rs7589318; rs7605927; rs934778

# Macromolecular_Interacting_Partner_1_General_References:
6274691; 6299668; 6314261; 3606677; 6254047; 6945581; 6267033; 6272808; 4352834; 4334191; 4338630; 4347148; 1264228; 195688; 2424570; 2839146; 7828531; 9768693; 10193875; 11244459

# Macromolecular_Interacting_Partner_1_References:
16772325; 16772347; 16828761; 16869285

# Macromolecular_Interacting_Partner_2_ID:
7549

# Macromolecular_Interacting_Partner_2_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
INS

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_2_Signals:
1-24

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
INS

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_2_Locus:
11p15.5

# Macromolecular_Interacting_Partner_2_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_2_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_2_References:
16847493; 16876572; 16876586; 16934435

# Macromolecular_Interacting_Partner_3_ID:
8108

# Macromolecular_Interacting_Partner_3_Name:
Angiotensinogen precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
Serpin A8[Contains: Angiotensin-1; Angiotensin I; Ang I; Angiotensin-2; Angiotensin II; Ang II; Angiotensin-3; Angiotensin III; Ang III; Des-Asp[1]-angiotensin II]

# Macromolecular_Interacting_Partner_3_Gene_Name:
AGT

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Angiotensinogen precursor
MRKRAPQSEMAPAGVSLRATILCLLAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAG
KPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGM
HSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKV
LSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLD
FTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEF
WVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLT
FQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIR
VGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVAN
PLSTA

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
485

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
53155

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.27

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  protease inhibitor activity
Function:  endopeptidase inhibitor activity
Function:  serine-type endopeptidase inhibitor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Angiotensin-3 stimulates aldosterone release

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00079:Serpin

# Macromolecular_Interacting_Partner_3_Signals:
1-33

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
178640

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
ANGT_HUMAN (P01019)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
AGT

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
AGT

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:333

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1458 bp
ATGCGGAAGCGAGCACCCCAGTCTGAGATGGCTCCTGCCGGTGTGAGCCTGAGGGCCACC
ATCCTCTGCCTCCTGGCCTGGGCTGGCCTGGCTGCAGGTGACCGGGTGTACATACACCCC
TTCCACCTCGTCATCCACAATGAGAGTACCTGTGAGCAGCTGGCAAAGGCCAATGCCGGG
AAGCCCAAAGACCCCACCTTCATACCTGCTCCAATTCAGGCCAAGACATCCCCTGTGGAT
GAAAAGGCCCTACAGGACCAGCTGGTGCTAGTCGCTGCAAAACTTGACACCGAAGACAAG
TTGAGGGCCGCAATGGTCGGGATGCTGGCCAACTTCTTGGGCTTCCGTATATATGGCATG
CACAGTGAGCTATGGGGCGTGGTCCATGGGGCCACCGTCCTCTCCCCAACGGCTGTCTTT
GGCACCCTGGCCTCTCTCTATCTGGGAGCCTTGGACCACACAGCTGACAGGCTACAGGCA
ATCCTGGGTGTTCCTTGGAAGGACAAGAACTGCACCTCCCGGCTGGATGCGCACAAGGTC
CTGTCTGCCCTGCAGGCTGTACAGGGCCTGCTAGTGGCCCAGGGCAGGGCTGATAGCCAG
GCCCAGCTGCTGCTGTCCACGGTGGTGGGCGTGTTCACAGCCCCAGGCCTGCACCTGAAG
CAGCCGTTTGTGCAGGGCCTGGCTCTCTATACCCCTGTGGTCCTCCCACGCTCTCTGGAC
TTCACAGAACTGGATGTTGCTGCTGAGAAGATTGACAGGTTCATGCAGGCTGTGACAGGA
TGGAAGACTGGCTGCTCCCTGATGGGAGCCAGTGTGGACAGCACCCTGGCTTTCAACACC
TACGTCCACTTCCAAGGGAAGATGAAGGGCTTCTCCCTGCTGGCCGAGCCCCAGGAGTTC
TGGGTGGACAACAGCACCTCAGTGTCTGTTCCCATGCTCTCTGGCATGGGCACCTTCCAG
CACTGGAGTGACATCCAGGACAACTTCTCGGTGACTCAAGTGCCCTTCACTGAGAGCGCC
TGCCTGCTGCTGATCCAGCCTCACTATGCCTCTGACCTGGACAAGGTGGAGGGTCTCACT
TTCCAGCAAAACTCCCTCAACTGGATGAAGAAACTGTCTCCCCGGACCATCCACCTGACC
ATGCCCCAACTGGTGCTGCAAGGATCTTATGACCTGCAGGACCTGCTCGCCCAGGCTGAG
CTGCCCGCCATTCTGCACACCGAGCTGAACCTGCAAAAATTGAGCAATGACCGCATCAGG
GTGGGGGAGGTGCTGAACAGCATTTTTTTTGAGCTTGAAGCGGATGAGAGAGAGCCCACA
GAGTCTACCCAACAGCTTAACAAGCCTGAGGTCTTGGAGGTGACCCTGAACCGCCCATTC
CTGTTTGCTGTGTATGATCAAAGCGCCACTGCCCTGCACTTCCTGGGCCGCGTGGCCAAC
CCGCTGAGCACAGCATGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
K02215

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_3_Locus:
1q42-q43

# Macromolecular_Interacting_Partner_3_SNPs:
rs11568032; rs699; rs11568053; rs34829218; rs4762; rs11568041; rs2478522; rs5040; rs11568052; rs2004776; rs3789679; rs7539020; rs3789678; rs11568028; rs11568050; rs2493134; rs3889728; rs11568051; rs1078499; rs11568025; rs11568022; rs7539013; rs2148582; rs11568024; rs3827750; rs11568023; rs11568026; rs11122576; rs5050; rs5044; rs11568021; rs11568027; rs11568049; rs11568029; rs11122578; rs11568030; rs5051; rs4753; rs11122577; rs11568031; rs5043; rs5042; rs913147; rs1326883; rs5052; rs7079; rs2478539; rs2493132; rs2493129; rs3789671; rs1926722; rs11568055; rs10864772; rs11568044; rs3789669; rs11568036; rs11568034; rs3789664; rs11568040; rs3789666; rs11568045; rs2478543; rs2478545; rs6687360; rs1926723; rs2493133; rs11568039; rs2478544; rs2493131; rs11122575; rs11568054; rs3827749; rs11568056; rs2493130; rs3789677; rs11568038; rs11568042; rs2478523; rs11568035; rs11568037; rs3789670; rs3789667; rs11568043; rs3789672; rs11568033; rs7543316; rs10864771; rs10864770; rs943580; rs11568048; rs11568014; rs5046; rs6683321; rs7536290; rs2071404; rs5049; rs2067853; rs11568057; rs11568019; rs11568016; rs11122580; rs11122574; rs11568015; rs943581; rs2071406; rs2071405; rs2493136; rs11568018; rs11122573; rs5045; rs11568046; rs5048; rs2478524; rs5047; rs2493135; rs16852352; rs11568017; rs11568020; rs7533803; rs5039; rs1805090; rs5041; rs11557882; rs13306155; rs11557881; rs1803105; rs2229389; rs11557883; rs41271499; rs17856352; rs11557884; rs11557886; rs11557885; rs4029126; rs1803106; rs1803104; rs34099195; rs15022; rs1800585; rs1045464; rs11684; rs35680836; rs1803103; rs35832019; rs28730748; rs34041147; rs34069211; rs35937843; rs12125552; rs13306154; rs3789665; rs35832452; rs34924695; rs34433365; rs36218431; rs10545629; rs10593363; rs34758442; rs5781599; rs11445360; rs34933000; rs36218766; rs1051038; rs10864769; rs10864773; rs12042687; rs12059975; rs12083907; rs12723373; rs12746025; rs1326885; rs1326886; rs1410142; rs1410144; rs1854053; rs2296801; rs2478534; rs2493125; rs2493127; rs2493137; rs3789657; rs3789662; rs4028824; rs4284270; rs4628514; rs4846866; rs7524283; rs7549009; rs7555650; rs9804147

# Macromolecular_Interacting_Partner_3_General_References:
6089875; 2924688; 1692023; 2885106; 3579322; 7259779; 7539791; 4300938; 3934016; 1132082; 9492317; 1394429; 8513325; 7607642; 7744780; 8621667

# Macromolecular_Interacting_Partner_3_References:
16933187; 17095589

# Macromolecular_Interacting_Partner_4_ID:
8249

# Macromolecular_Interacting_Partner_4_Name:
Corticoliberin precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone

# Macromolecular_Interacting_Partner_4_Gene_Name:
CRH

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Corticoliberin precursor
MRLPLLVSAGVLLVALLPCPPCRALLSRGPVPGARQAPQHPQPLDFFQPPPQSEQPQQPQ
ARPVLLRMGEEYFLRLGNLNKSPAAPLSPASSLLAGGSGSRPSPEQATANFFRVLLQQLL
LPRRSLDSPAALAERGARNALGGHQEAPERERRSEEPPISLDLTFHLLREVLEMARAEQL
AQQAHSNRKLMEIIGK

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
196

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
21422

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
10.55

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
This hormone from hypothalamus regulates the release of corticotropin from pituitary gland

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00473:CRF

# Macromolecular_Interacting_Partner_4_Signals:
1-24

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
35356

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
CRF_HUMAN (P06850)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
CRH

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
CRH

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:2355

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>591 bp
ATGCGGCTGCCGCTGCTTGTGTCCGCGGGAGTCCTGCTGGTGGCTCTCCTGCCCTGCCCG
CCATGCAGGGCGCTCCTGAGCCGCGGGCCGGTCCCGGGAGCTCGGCAGGCGCCGCAGCAC
CCTCAGCCCTTGGATTTCTTCCAGCCGCCGCCGCAGTCCGAGCAGCCCCAGCAGCCGCAG
GCTCGGCCGGTCCTGCTCCGCATGGGAGAGGAGTACTTCCTCCGCCTGGGGAACCTCAAC
AAGAGCCCGGCCGCTCCCCTTTCGCCCGCCTCCTCGCTCCTCGCCGGAGGCAGCGGCAGC
CGCCCTTCGCCGGAACAGGCGACCGCCAACTTTTTCCGCGTGTTGCTGCAGCAGCTGCTG
CTGCCTCGGCGCTCGCTCGACAGCCCCGCGGCTCTCGCGGAGCGCGGCGCTAGGAATGCC
CTCGGCGGCCACCAGGAGGCACCGGAGAGAGAAAGGCGGTCCGAGGAGCCTCCCATCTCC
CTGGATCTCACCTTCCACCTCCTCCGGGAAGTCTTGGAAATGGCCAGGGCCGAGCAGTTA
GCACAGCAAGCTCACAGCAACAGGAAACTCATGGAGATTATTGGGAAATAA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
V00571

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:8

# Macromolecular_Interacting_Partner_4_Locus:
8q13

# Macromolecular_Interacting_Partner_4_SNPs:
rs6159; rs3176921; rs6472257; rs6999780; rs6982394; rs6158; rs6156; rs7459924; rs6157; rs35365635; rs41545719; rs11309939; rs3832590; rs10086258; rs10090644; rs10090752; rs10093091; rs10098823; rs10105164; rs1054108; rs10957368; rs11986876; rs11993711; rs11997294; rs11997416; rs11997816; rs12543727; rs12721507; rs12721508; rs12721509; rs12721510; rs12721511; rs16932615; rs1870392; rs4344056; rs4501563; rs5030875; rs5030877; rs6472258; rs6472259; rs6984398; rs6990486; rs6996265; rs6999100; rs7010547; rs7013524; rs7350113; rs7816410; rs7832858; rs7835214; rs7839698

# Macromolecular_Interacting_Partner_4_General_References:
6605851; 2783917; 3262120; 8386360

# Macromolecular_Interacting_Partner_4_References:
17029676; 17086345; 17095588

# Macromolecular_Interacting_Partner_5_ID:
8202

# Macromolecular_Interacting_Partner_5_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_5_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_5_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_5_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_5_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_5_Locus:
10q22

# Macromolecular_Interacting_Partner_5_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_5_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_5_References:
16772739; 16854373; 16883626; 16954814

# Macromolecular_Interacting_Partner_6_ID:
8570

# Macromolecular_Interacting_Partner_6_Name:
Catechol-O-methyltransferase domain-containing protein 1

# Macromolecular_Interacting_Partner_6_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_6_Gene_Name:
COMTD1

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>CatecholOmethyltransferase domaincontaining protein 1
MTQPVPRLSVPAALALGSAALGAAFATGLFLGRRCPPWRGRREQCLLPPEDSRLWQYLLS
RSMREHPALRSLRLLTLEQPQGDSMMTCEQAQLLANLARLIQAKKALDLGTFTGYSALAL
ALALPADGRVVTCEVDAQPPELGRPLWRQAEAEHKIDLRLKPALETLDELLAAGEAGTFD
VAVVDADKENCSAYYERCLQLLRPGGILAVLRVLWRGKVLQPPKGDVAAECVRNLNERIR
RDVRVYISLLPLGDGLTLAFKI

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
262

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
28809

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
8.48

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  O-methyltransferase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Putative O-methyltransferase (Potential)

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF01596:Methyltransf_3

# Macromolecular_Interacting_Partner_6_Signals:
1-26

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
12-32

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
CMTD1_HUMAN (Q86VU5)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
COMTD1

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
COMTD1

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:26309

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
AY358476

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_6_Locus:
10q22.2

# Macromolecular_Interacting_Partner_6_SNPs:
rs1259503; rs1259505; rs905884; rs1259504; rs7899856; rs1054321; rs5786169; rs34935511; rs11001336; rs41280438; rs35436536; rs36126228; rs878057; rs34517493; rs36023647; rs10673436; rs1259506; rs34262268; rs11001337; rs34816088; rs5786170; rs34397644; rs1259507; rs10128329; rs10159747; rs10824293; rs11001334; rs1259498; rs1259501; rs1259502; rs1259508; rs1259523; rs1259524; rs1259525; rs1505378; rs34004083; rs34070926; rs4746276; rs6480772; rs7069746; rs7894555

# Macromolecular_Interacting_Partner_6_General_References:
12975309

# Macromolecular_Interacting_Partner_6_References:
Not Available

# Macromolecular_Interacting_Partner_7_ID:
8841

# Macromolecular_Interacting_Partner_7_Name:
Chromaffin granule amine transporter

# Macromolecular_Interacting_Partner_7_Synonyms:
Vesicular amine transporter 1; VAT1; Solute carrier family 18 member 1

# Macromolecular_Interacting_Partner_7_Gene_Name:
SLC18A1

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Chromaffin granule amine transporter
MLRTILDAPQRLLKEGRASRQLVLVVVFVALLLDNMLFTVVVPIVPTFLYDMEFKEVNSS
LHLGHAGSSPHALASPAFSTIFSFFNNNTVAVEESVPSGIAWMNDTASTIPPPATEAISA
HKNNCLQGTGFLEEEITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLS
TVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGL
LVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLFMLLKDP
YILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLA
NKMGRWLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDL
RHTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVINIVYAPLCYYLRS
PPAKEEKLAILSQDCPMETRMYATQKPTKEFPLGEDSDEEPDHEE

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
525

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
56258

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
5.79

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
 Function:  transporter activity
Function:  drug transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  drug transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_7_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_7_Specific_Function:
Involved in the vesicular transport of biogenic amines

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF07690:MFS_1

# Macromolecular_Interacting_Partner_7_Signals:
1-39

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
22-42
139-158
168-188
198-218
228-250
257-279
300-319
336-360
366-386
398-418
423-443
449-470

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
1314290

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
VMAT1_HUMAN (P54219)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
SLC18A1

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
SLC18A1

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:10934

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Cytoplasmic vesicle; cytoplasmic vesicle membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1578 bp
ATGCTCCGGACCATTCTGGATGCTCCCCAGCGGTTGCTGAAGGAGGGGAGAGCGTCCCGG
CAGCTGGTGCTGGTGGTGGTATTCGTCGCTTTGCTCCTGGACAACATGCTGTTTACTGTG
GTGGTGCCAATTGTGCCCACCTTCCTATATGACATGGAGTTCAAAGAAGTCAACTCTTCT
CTGCACCTCGGCCATGCCGGAAGTTCCCCACATGCCCTCGCCTCTCCTGCCTTTTCCACC
ATCTTCTCCTTCTTCAACAACAACACCGTGGCTGTTGAAGAAAGCGTACCTAGTGGAATA
GCATGGATGAATGACACTGCCAGCACCATCCCACCTCCAGCCACTGAAGCCATCTCAGCT
CATAAAAACAACTGCTTGCAAGGCACAGGTTTCTTGGAGGAAGAGATTACCCGGGTCGGG
GTTCTGTTTGCTTCAAAGGCTGTGATGCAACTTCTGGTCAACCCATTCGTGGGCCCTCTC
ACCAACAGGATTGGATATCATATCCCCATGTTTGCTGGCTTTGTTATCATGTTTCTCTCC
ACAGTTATGTTTGCTTTTTCTGGGACCTATACTCTACTCTTTGTGGCCCGAACCCTTCAA
GGCATTGGATCTTCATTTTCATCTGTTGCAGGTCTTGGAATGCTGGCCAGTGTCTACACT
GATGACCATGAGAGAGGACGAGCCATGGGAACTGCTCTGGGGGGCCTGGCCTTGGGGTTG
CTGGTGGGAGCTCCCTTTGGAAGTGTAATGTACGAGTTTGTTGGGAAGTCTGCACCCTTC
CTCATCCTGGCCTTCCTGGCACTACTGGATGGAGCACTCCAGCTTTGCATCCTACAGCCT
TCCAAAGTCTCTCCTGAGAGTGCCAAGGGGACTCCCCTCTTTATGCTTCTCAAAGACCCT
TACATCCTGGTGGCTGCAGGGTCCATCTGCTTTGCCAACATGGGGGTGGCCATCCTGGAG
CCCACACTGCCCATCTGGATGATGCAGACCATGTGCTCCCCCAAGTGGCAGCTGGGTCTA
GCTTTCTTGCCTGCCAGTGTGTCCTACCTCATTGGCACCAACCTCTTTGGTGTGTTGGCC
AACAAGATGGGTCGGTGGCTGTGTTCCCTAATCGGGATGCTGGTAGTAGGTACCAGCTTG
CTCTGTGTTCCTCTGGCTCACAATATTTTTGGTCTCATTGGCCCCAATGCAGGGCTTGGC
CTTGCCATAGGCATGGTGGATTCTTCTATGATGCCCATCATGGGGCACCTGGTGGATCTA
CGCCACACCTCGGTGTATGGGAGTGTCTACGCCATCGCTGATGTGGCTTTTTGCATGGGC
TTTGCTATAGGTCCATCCACCGGTGGTGCCATTGTAAAGGCCATCGGTTTTCCCTGGCTC
ATGGTCATCACTGGGGTCATCAACATCGTCTATGCTCCACTCTGCTACTACCTGCGGAGC
CCCCCGGCAAAGGAAGAGAAGCTTGCTATTCTGAGTCAGGACTGCCCCATGGAGACCCGG
ATGTATGCAACCCAGAAGCCCACGAAGGAATTTCCTCTGGGGGAGGACAGTGATGAGGAG
CCTGACCATGAGGAGTAG

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
U39905

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:8

# Macromolecular_Interacting_Partner_7_Locus:
8p21.3

# Macromolecular_Interacting_Partner_7_SNPs:
rs1390938; rs17092104; rs2270637; rs17215808; rs2270641; rs17215822; rs17215759; rs17092129; rs2270648; rs17222183; rs17215787; rs721950; rs12549838; rs1390939; rs1497020; rs12549837; rs4921694; rs2270642; rs4922137; rs13269955; rs2270644; rs2270643; rs721951; rs1908809; rs1532446; rs2132699; rs6586897; rs2088340; rs2088343; rs903997; rs952860; rs7006986; rs10112060; rs2279708; rs952858; rs6992927; rs1018079; rs6586896; rs1390942; rs13258461; rs952859; rs17092097; rs11204098; rs6992702; rs2279709; rs3735835; rs4922132; rs7841346; rs7013199; rs1497025; rs3779670; rs6586898; rs11989335; rs10102779; rs12545707; rs11987726; rs2270638; rs7014452; rs6982009; rs2270650; rs6986004; rs17092107; rs17222134; rs17411775; rs17489891; rs7007385; rs1390937; rs2015202; rs6989379; rs7827215; rs2132700; rs3779672; rs11989477; rs2270649; rs4921692; rs17092126; rs6994511; rs13266221; rs4922133; rs11774649; rs17489905; rs3779671; rs7820651; rs7011982; rs17840569; rs17092137; rs7014413; rs10216668; rs7002781; rs7828538; rs6987705; rs1813640; rs6997277; rs2088342; rs17092131; rs11986106; rs7812462; rs1497023; rs2270652; rs4921693; rs3779673; rs7010970; rs10283363; rs1497022; rs7828618; rs7010744; rs11204097; rs7003858; rs12547375; rs988713; rs11204096; rs13268842; rs17092083; rs3757960; rs7836907; rs17092144; rs13264938; rs2270645; rs17092091; rs34201967; rs4921695; rs2270647; rs34489221; rs2270646; rs3824122; rs9886453; rs35711001; rs36178996; rs13267563; rs34758432; rs10216526; rs13266515; rs34380936; rs7008229; rs10560327; rs17092106; rs28393220; rs13254049; rs28701666; rs7836082; rs34699818; rs5018722; rs34461999; rs2270639; rs7842711; rs10528221; rs13264769; rs34547886; rs4244460; rs6997438; rs11787343; rs2270640; rs17840570; rs11345261; rs7009177; rs13266227; rs35616580; rs35241387; rs34789619; rs7843545; rs2270651; rs13272341; rs17092136; rs36021577; rs35242639; rs34135174; rs35590614; rs34108083; rs4579546; rs3043842; rs28677856; rs13265473; rs2410637; rs17092132; rs34884871; rs2279710; rs28491510; rs7005635; rs11985004; rs10094232; rs36022472; rs28633772; rs28520251; rs34429137; rs28628307; rs34004632; rs28873390; rs13259196; rs34091371; rs35272127; rs28581346; rs28494669; rs10102445; rs13248157; rs13274124; rs34357050; rs34708641; rs34355694; rs6986634; rs28609982; rs10095858; rs28662172; rs35530484; rs34728683; rs17092115; rs33999400; rs6986377; rs13250997; rs13264146; rs34860475; rs2410636; rs35530901; rs6989871; rs10108611; rs34048931; rs7009166; rs34933233; rs17092134; rs28621370; rs5889901; rs10701629; rs35434077; rs35563299; rs28577098; rs6993213; rs35878337; rs28415506; rs10599153; rs2018681; rs28435279; rs35946395; rs35914215; rs2088341; rs36088196; rs17489926; rs10692089; rs34937185; rs35655118; rs12549750; rs2173113; rs1982960; rs3757959; rs3757958; rs34910259; rs3834367; rs10088489; rs10099144; rs10099366; rs11204095; rs11783752; rs11986163; rs11997907; rs12171680; rs13253037; rs13265218; rs13279675; rs13280941; rs17215717; rs17222106; rs17222127; rs17222141; rs17222148; rs17222155; rs2047360; rs2173114; rs35091123; rs3757961; rs4481613; rs4921691; rs4922131; rs6982939; rs7008859; rs7013494; rs7013942; rs7820517; rs987778

# Macromolecular_Interacting_Partner_7_General_References:
8643547

# Macromolecular_Interacting_Partner_7_References:
Not Available

End of HMDB00068

Beginning of HMDB00070
# Accession_No:
HMDB00070

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-09-17 16:48:20

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Pipecolic acid

# Description:
Pipecolic acid is a metabolite of lysine found in human physiological fluids such as urine, plasma and CSF.  However, it is uncertain if pipecolic acid originates directly from food intake or from mammalian or intestinal bacterial enzyme metabolism. Recent studies suggest that plasma pipecolic acid, particularly the D-isomer, originates mainly from the catabolism of dietary lysine by intestinal bacteria rather than by direct food intake.  In classic Zellweger syndrome (a cerebro-hepato-renal genetic disorder, OMIM 214100) pipecolic acid accumulate in the plasma of the patients. It is known that plasma pipecolic acid levels are also elevated in patients with chronic liver diseases.  Pipecolic acid is moderately elevated in patients with pyridoxine-dependent seizures and might therefore be a possible biochemical marker for selecting candidates for pyridoxine therapy (Plecko et al 2000). Pipecolic acid was also elevated in CSF in these vitamin B6-responsive patients. (PMID 12705501)

# Synonyms:
(+/-)-2-Piperidinecarboxylate; (+/-)-2-Piperidinecarboxylic acid; (+/-)-Pipecolate; (+/-)-Pipecolic acid; (+/-)-Pipecolinate; (+/-)-Pipecolinic acid; (RS)-2-Piperidinecarboxylate; (RS)-2-Piperidinecarboxylic acid; 2-Carboxypiperidine; 2-Piperidinecarboxylate; 2-Piperidinecarboxylic acid; DL-2-Piperidinecarboxylate; DL-2-Piperidinecarboxylic acid; DL-Pipecolate; DL-Pipecolic acid; DL-Pipecolinate; DL-Pipecolinic acid; Dihydrobaikiane; Hexahydro-2-picolinate; Hexahydro-2-picolinic acid; Hexahydropicolinate; Hexahydropicolinic acid; Homoproline; Pipecolate; Pipecolic acid; Pipecolinate; Pipecolinic acid; Piperolinate; Piperolinic acid; a-Pipecolinate; a-Pipecolinic acid; acide pipecolique; acide piperidine-carboxylique-2; alpha-Pipecolinate; alpha-Pipecolinic acid

# Chemical_IUPAC_Name:
piperidine-2-carboxylic acid

# Chemical_Formula:
C6H11NO2

# Chemical_Structure:
tbl_chemical:::HMDB00070_ZOOM.png:::119283171896679443

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00070_THUMB.png:::119283171736020815

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Nitrogenous Compounds

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
secondary amine; secondary aliphatic amine (dialkylamine); carboxylic acid; heterocyclic compound; alpha-aminoacid

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
129.07898

# Molecular_Weight_Avg:
129.15704

# Smiles_String_isomeric:
OC(=O)[C@@H]1CCCCN1

# Smiles_String_canonical:
OC(=O)C1CCCCN1

# KEGG_Compound_ID:
C00408

# BioCyc_ID:
5-HYDROXY-PIPECOLATE

# PubChem_CID:
439227

# PubChem_SID:
7886740; 3139246; 8145357; 3698; 10298256

# OMIM_ID:
202370; 214100; 231690; 239400; 266500; 266510; 600964

# Metagene_ID:
INFANTILE REFSUM'S DISEASE: 123; D-BIFUNCTIONAL PROTEIN DEFICIENCY: 470; ZELLWEGER SYNDROME: 36; ADRENOLEUKODYSTROPHY, X-LINKED: 199; HYPERPIPECOLATEMIA: 218; PEROXISOMAL DISORDERS, NEW TYPE, LIVER: 277; HYPERLYSINEMIA I, FAMILIAL: 212; PYRIDOXINE DEPENDENCY WITH SEIZURES: 360; ADRENOLEUKODYSTROPHY, NEONATAL: 317; PSEUDO ZELLWEGER -> D-BIFUNCTIONAL PROTEIN DEFICIENCY: 110

# BiGG_ID:
Not Available

# Wikipedia_ID:
Not Available

# METLIN_ID:
50

# Ref_ID:
3356409; 6811962; 3769211; 11865422; 1113225; 10894227; 7299546; 15206793; 3116331; 1204235; 12964115; 11270189; 3315316; 12705501; 6817963; 10509903

# ChEBI_ID:
17964

# CAS_Registry_Number:
535-75-1

# InChI:
InChI=1/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1

# Synthesis_Reference:
 Journal of Organic Chemistry  (1962),  27  284-6

# Melting_Point:
~264 (dec.)

# Melting_Point_predicted:
90.3 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
314 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
74.1 mg/mL [MEYLAN,WM et al. (1996)]; 158.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.16 [Predicted by ALOGPS]; -2 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00408.mol:::1132723804968203159

# SDF_File_[Text]:
tbl_chemical:::HMDB00070.sdf:::119283171402878596

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00070.pdb:::119283171599269492

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::Pipecolic Acid_00070.zip:::118246125530518715

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041009_P00_03_HW_assigned.png:::118246125533861938

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041009_P00_03_HW_2DHSQC_879.png:::114805614643386884

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041009_P00_03_HW_2DHSQC_879.zip:::114805614643830295

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041009_P00_03_HW_2DHSQC_879_Assigned.png:::116241583951861646

# Predicted_H_NMR_Spectrum:
tbl_chemical:::DL-Pipecolic acid.gif:::1132732105140863042

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00070_peaks.txt:::1156309525576458711

# Predicted_C_NMR_Spectrum:
tbl_chemical:::DL-Pipecolic acid_C.gif:::1132737674392893871

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00070_peaks.txt:::1156310715966366134

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00070L.png:::117555262933356541; Medium Energy:tbl_ms:::HMDB00070M.png:::117555268237885497; High Energy:tbl_ms:::HMDB00070H.png:::117555271608219920

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000237.png:::116907445056228000

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000237.txt:::116907445056222086

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000237.png:::11689083245002157

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000237.txt:::116890832487515436

# Cellular_Location:
cytoplasm; extracellular

# Tissue_Location:
Gut (Via Endogenous Microbial Flora); Liver

# deuterated:
No

# Biofluid_Location:
Amniotic Fluid; Blood; CSF; Urine

# Concentration_[Normal]:
Urine	0.03 +/-0.07	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	10509903
Blood	2.46 +/- 1.26	uM	Adult:>18_yrs_old	Both	Normal	12705501
Blood	5.73 (3.75 - 10.8)	uM	Newborn:0-30_days_old	Both	Normal	3315316
Blood	10.0 (0.0-20.0)	umol/L	Children:1-13_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 85-97. Edited by Cornelius Lentner. ; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. ; Basle, Switzerland c1981-1992.
Blood	1.20 +/-0.11	umol/L	Adult:>18_yrs_old	Both	Normal	10509903
Cerebrospinal_Fluid(CSF)	0.009 - 0.12	uM	Adult:>18_yrs_old	Both	Normal	12705501
Cerebrospinal_Fluid(CSF)	0.08 (0.07-0.10)	umol/L	Adult:>18_yrs_old	N/A	Normal	11865422
Cerebrospinal_Fluid(CSF)	0.017 +/- 0.005	umol/L	Adult:>18_yrs_old	N/A	Normal	15206793
Amniotic_Fluid	4.65 (2.24 - 8.40)	uM	N/A	Both	Normal	3315316


# Concentration_[Abnormal]:
Urine	0.02-228.3	umol/mmol_creatinine	Children:1-13_yrs_old	N/A	Zellweger Syndrome	3769211
Cerebrospinal_Fluid(CSF)	0.053 (0.023-0.083)	umol/L	Adult:>18_yrs_old	Both	Brain oedema or injury	15206793
Cerebrospinal_Fluid(CSF)	0.19 (0.17-0.21)	umol/L	Adult:>18_yrs_old	N/A	Severe Malaria	11865422
Cerebrospinal_Fluid(CSF)	0.38 (0.11-1.26)	umol/L	N/A	N/A	Anemia	12964115
Cerebrospinal_Fluid(CSF)	0.18 (0.14-0.22)	umol/L	N/A	N/A	Cerebral malaria	12964115
Cerebrospinal_Fluid(CSF)	0.17 (0.12-0.23)	umol/L	N/A	N/A	TB meningitis	12964115
Cerebrospinal_Fluid(CSF)	0.06 (0.02-0.26)	umol/L	Adult:>18_yrs_old	N/A	Uncomplicated malaria	12964115
Cerebrospinal_Fluid(CSF)	0.05 (0.02-0.09)	umol/L	Adult:>18_yrs_old	N/A	Convulsions	12964115


# Associated_Disorders:
Anemia; Brain oedema or injury; Cerebral malaria; Chronic Liver Disease; Convulsions; Epilepsy; Peroxisomal Disorders; Severe Malaria; TB meningitis; Uncomplicated malaria; Zellweger Syndrome

# Pathway_Names:
Lysine degradation

# Pathway_Images:
Lysine_degradation.jpg

# KEGG_Images:
map00310

# Pathway_Graphs:
Lysine_degradation_Graph.jpg

# Pathway_SBMLs:
Lysine_degradation.xml

# Metabolic_Enzyme_1_ID:
5354

# Metabolic_Enzyme_1_Name:
Peroxisomal sarcosine oxidase

# Metabolic_Enzyme_1_Synonyms:
PSO; L-pipecolate oxidase; L-pipecolic acid oxidase

# Metabolic_Enzyme_1_Gene_Name:
PIPOX

# Metabolic_Enzyme_1_Protein_Sequence:
>Peroxisomal sarcosine oxidase
MAAQKDLWDAIVIGAGIQGCFTAYHLAKHRKRILLLEQFFLPHSRGSSHGQSRIIRKAYL
EDFYTRMMHECYQIWAQLEHEAGTQLHRQTGLLLLGMKENQELKTIQANLSRQRVEHQCL
SSEELKQRFPNIRLPRGEVGLLDNSGGVIYAYKALRALQDAIRQLGGIVRDGEKVVEINP
GLLVTVKTTSRSYQAKSLVITAGPWTNQLLRPLGIEMPLQTLRINVCYWREMVPGSYGVS
QAFPCFLWLGLCPHHIYGLPTGEYPGLMKVSYHHGNHADPEERDCPTARTDIGDVQILSS
FVRDHLPDLKPEPAVIESCMYTNTPDEQFILDRHPKYDNIVIGAGFSGHGFKLAPVVGKI
LYELSMKLTPSYDLAPFRISRFPSLGKAHL

# Metabolic_Enzyme_1_Number_of_Residues:
390

# Metabolic_Enzyme_1_Molecular_Weight:
44067

# Metabolic_Enzyme_1_Theoretical_pI:
8.54

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor
Function:  sarcosine oxidase activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  aromatic compound metabolism
Process:  folic acid and derivative metabolism
Process:  tetrahydrofolate metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Metabolizes sarcosine, L-pipecolic acid and L-proline

# Metabolic_Enzyme_1_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_1_Reaction:
L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01266:DAO

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
7-26

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.5.3.1;EC 1.5.3.7

# Metabolic_Enzyme_1_GenBank_ID_Protein:
7157903

# Metabolic_Enzyme_1_SwissProt_ID:
SOX_HUMAN (Q9P0Z9)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
PIPOX

# Metabolic_Enzyme_1_Geneatlas_id:
PIPOX

# Metabolic_Enzyme_1_hgnc_id:
HGNC:17804

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_1_Gene_Sequence:
>1173 bp
ATGGCGGCTCAGAAAGATCTCTGGGACGCCATTGTGATTGGGGCGGGGATCCAGGGCTGC
TTCACTGCATACCACCTCGCCAAACACAGGAAGAGGATCCTCCTGCTGGAGCAGTTCTTT
CTACCACACTCCCGAGGAAGCTCCCATGGACAAAGCCGGATAATCCGAAAGGCGTACCTG
GAAGACTTTTACACCCGGATGATGCATGAGTGCTATCAGATATGGGCCCAGCTGGAGCAC
GAGGCTGGAACCCAATTGCACAGGCAGACTGGATTACTGCTGCTGGGAATGAAAGAGAAT
CAAGAATTAAAGACAATCCAGGCCAATCTGTCGAGGCAGAGGGTAGAACACCAGTGTCTT
TCATCTGAGGAACTGAAGCAACGTTTCCCAAATATTCGGTTGCCCAGGGGAGAAGTGGGG
CTCTTGGACAATTCCGGAGGAGTTATCTATGCATATAAGGCCCTCAGAGCCCTGCAGGAT
GCAATTCGACAGCTAGGAGGCATAGTGCGTGACGGAGAGAAGGTGGTGGAGATAAACCCA
GGGCTACTGGTCACGGTGAAAACCACCTCCAGGAGCTACCAAGCTAAGAGCTTGGTCATC
ACAGCAGGTCCTTGGACCAACCAGCTCCTCCGTCCCCTGGGCATTGAGATGCCTCTCCAG
ACCCTGCGGATCAACGTGTGTTACTGGCGAGAGATGGTTCCTGGGAGCTATGGTGTGTCC
CAGGCCTTTCCGTGCTTCCTGTGGCTGGGCTTGTGTCCCCACCACATCTACGGACTGCCC
ACAGGAGAGTACCCAGGGCTGATGAAGGTCAGCTATCACCACGGCAACCACGCAGACCCT
GAGGAGCGGGACTGCCCCACAGCACGCACAGACATCGGAGACGTCCAGATCCTGAGCAGC
TTTGTCAGAGATCACTTACCTGATCTGAAGCCCGAGCCTGCTGTCATTGAGAGCTGCATG
TACACGAATACCCCTGATGAGCAGTTCATTCTCGATCGCCACCCAAAGTATGACAACATT
GTCATTGGTGCTGGATTCTCTGGGCACGGGTTCAAGCTGGCCCCTGTGGTGGGGAAGATC
CTGTATGAATTAAGCATGAAATTAACACCATCTTATGACTTGGCACCTTTTCGAATCAGC
CGTTTCCCAAGCCTGGCCAAAGCCCACCTGTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF134593

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_1_Locus:
17q11.2

# Metabolic_Enzyme_1_SNPs:
rs9890082; rs9912656; rs8081500; rs8067658; rs9908931; rs8067401; rs7211084; rs17795242; rs8077381; rs6505106; rs8066520; rs11869504; rs8078346; rs4795491; rs3736253; rs12325690; rs7225763; rs7217905; rs11868047; rs7211375; rs12326022; rs6505105; rs4794849; rs11869124; rs11869243; rs7213119; rs17852448; rs17856772; rs17856771; rs17856770; rs17852449; rs7223527; rs34642085; rs35277021; rs11291050; rs5819860; rs35037948; rs35675206; rs11424309; rs35805984; rs3884011; rs33913117; rs9899482; rs8074269; rs35121520; rs7224285; rs34991975; rs11404274; rs35812484; rs11652008; rs34431204; rs35429458; rs34830053; rs33927135; rs35145427; rs11386770; rs35719076; rs11653331; rs11655979; rs11869703; rs11869891; rs12150489; rs12936749; rs1319486; rs16964766; rs173248; rs184735; rs189460; rs191562; rs192126; rs193239; rs239268; rs4965971; rs507040; rs507917; rs507949; rs545347; rs546127; rs560156; rs637579; rs7209257; rs7209803; rs7220662; rs7221150; rs8064530; rs8069593; rs8070009; rs8076228; rs8081869; rs8082295; rs9898869; rs9913000

# Metabolic_Enzyme_1_General_References:
10642506; 10931946

# Metabolic_Enzyme_1_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7938

# Macromolecular_Interacting_Partner_1_Name:
Delta-type opioid receptor

# Macromolecular_Interacting_Partner_1_Synonyms:
DOR-1

# Macromolecular_Interacting_Partner_1_Gene_Name:
OPRD1

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Deltatype opioid receptor
MEPAPSAGAELQPPLFANASDAYPSAFPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
372

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
40413

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
9.17

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  peptide receptor activity, G-protein coupled
Function:  opioid receptor activity
Function:  delta-opioid receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
46-75
85-102
125-144
175-190
216-238
262-284
294-310

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
27545517

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
OPRD_HUMAN (P41143)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
OPRD1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
OPRD1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:8153

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1119 bp
ATGGAACCGGCCCCCTCCGCCGGCGCCGAGCTGCAGCCCCCGCTCTTCGCCAACGCCTCG
GACGCCTACCCTAGCGCCTTCCCCAGCGCTGGCGCCAATGCGTCGGGGCCGCCAGGCGCG
CGGAGCGCCTCGTCCCTCGCCCTGGCAATCGCCATCACCGCGCTCTACTCGGCCGTGTGC
GCCGTGGGGCTGCTGGGCAACGTGCTTGTCATGTTCGGCATCGTCCGGTACACTAAGATG
AAGACGGCCACCAACATCTACATCTTCAACCTGGCCTTAGCCGATGCGCTGGCCACCAGC
ACGCTGCCTTTCCAGAGTGCCAAGTACCTGATGGAGACGTGGCCCTTCGGCGAGCTGCTC
TGCAAGGCTGTGCTCTCCATCGACTACTACAATATGTTCACCAGCATCTTCACGCTCACC
ATGATGAGTGTTGACCGCTACATCGCTGTCTGCCACCCTGTCAAGGCCCTGGACTTCCGC
ACGCCTGCCAAGGCCAAGCTGATCAACATCTGTATCTGGGTCCTGGCCTCAGGCGTTGGC
GTGCCCATCATGGTCATGGCTGTGACCCGTCCCCGGGACGGGGCAGTGGTGTGCATGCTC
CAGTTCCCCAGCCCCAGCTGGTACTGGGACACGGTGACCAAGATCTGCGTGTTCCTCTTC
GCCTTCGTGGTGCCCATCCTCATCATCACCGTGTGCTATGGCCTCATGCTGCTGCGCCTG
CGCAGTGTGCGCCTGCTGTCGGGCTCCAAGGAGAAGGACCGCAGCCTGCGGCGCATCACG
CGCATGGTGCTGGTGGTTGTGGGCGCCTTCGTGGTGTGTTGGGCGCCCATCCACATCTTC
GTCATCGTCTGGACGCTGGTGGACATCGACCGGCGCGACCCGCTGGTGGTGGCTGCGCTG
CACCTGTGCATCGCGCTGGGCTACGCCAATAGCAGCCTCAACCCCGTGCTCTACGCTTTC
CTCGACGAGAACTTCAAGCGCTGCTTCCGCCAGCTCTGCCGCAAGCCCTGCGGCCGCCCA
GACCCCAGCAGCTTCAGCCGCGCCCGCGAAGCCACGGCCCGCGAGCGTGTCACCGCCTGC
ACCCCGTCCGATGGTCCCGGCGGTGGCGCTGCCGCCTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
U07882

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_1_Locus:
1p36.1-p34.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs1042114; rs2234918; rs4654327; rs529520; rs2236857; rs419335; rs498952; rs421300; rs499062; rs678849; rs2298895; rs545247; rs760588; rs6697423; rs204055; rs6669447; rs595725; rs204048; rs581111; rs6690810; rs2236861; rs3766951; rs485621; rs2318774; rs2298896; rs188116; rs6697404; rs589628; rs204047; rs4654323; rs537339; rs797406; rs513269; rs2318773; rs4654322; rs809992; rs556408; rs417051; rs487466; rs4233254; rs760589; rs7549829; rs509577; rs680090; rs533123; rs11803721; rs482387; rs7547259; rs427515; rs10753331; rs204083; rs797397; rs12404612; rs631398; rs538485; rs4654321; rs2236856; rs6426344; rs16837730; rs703182; rs204050; rs10915201; rs2873795; rs6426345; rs7511978; rs10915202; rs11586090; rs561180; rs12568804; rs797415; rs536706; rs172172; rs542991; rs797402; rs10799122; rs411340; rs7543079; rs2236858; rs797399; rs204051; rs2236854; rs426997; rs508448; rs2236855; rs1010262; rs480258; rs204053; rs16837737; rs10915205; rs2298897; rs204052; rs549080; rs204081; rs614824; rs639653; rs515994; rs16837719; rs10915204; rs10915200; rs6656759; rs13376241; rs204077; rs521809; rs204046; rs10159249; rs12749204; rs169446; rs618886; rs569356; rs204076; rs9282805; rs12731788; rs35411530; rs11398217; rs11283964; rs36110179; rs2236860; rs554986; rs16837736; rs11576623; rs204080; rs423292; rs414491; rs11576270; rs191870; rs34146064; rs12133192; rs204078; rs34582275; rs34263319; rs34428188; rs35532177; rs1683206; rs28409089; rs797409; rs34518692; rs5773218; rs34817362; rs12092160; rs11356247; rs386145; rs3079037; rs4654377; rs35334350; rs34385873; rs6681384; rs204049; rs489557; rs5773219; rs680825; rs7516162; rs1683205; rs590013; rs7536430; rs204079; rs12747612; rs35186744; rs12059981; rs482692; rs28820668; rs549090; rs11307166; rs489272; rs34467080; rs369247; rs2236859; rs514991; rs11287279; rs35332682; rs2298894; rs11306242; rs10915203; rs428561; rs797407; rs4654376; rs2298898; rs12039056; rs188118; rs6662638; rs681301; rs12732879; rs36004258; rs7541018; rs34787301; rs6657831; rs11449748; rs34765043; rs11307165; rs680824; rs34321858; rs675684; rs11803432; rs6690946; rs3831495; rs28560460; rs675134; rs34983691; rs7366584; rs34563832; rs398862; rs379714; rs797403; rs35558781; rs434827; rs4654375; rs389531; rs401345; rs527931; rs35857826; rs525672; rs204054; rs2002757; rs11361906; rs35558441; rs370000; rs797408; rs35111249; rs34346748; rs379301; rs549046; rs28531690; rs36117899; rs35684742; rs11416681; rs35664518; rs36018454; rs28485136; rs5773220; rs382016; rs797405; rs35996756; rs35734700; rs34907861; rs12089573; rs34400316; rs12755155; rs11350728; rs6671092; rs7515442; rs35006589; rs6703325; rs34603985; rs797404; rs28474854; rs34994062; rs413991; rs189962; rs204082; rs12750985; rs35417198; rs12064614; rs169450; rs175969; rs204062; rs204066; rs204067; rs204068; rs204069; rs204070; rs204074; rs204075; rs379944; rs3820248; rs451483; rs461173; rs6692039; rs988957

# Macromolecular_Interacting_Partner_1_General_References:
8201839; 7808419; 10982041

# Macromolecular_Interacting_Partner_1_References:
16562131

End of HMDB00070

Beginning of HMDB00071
# Accession_No:
HMDB00071

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-06-21 14:19:33

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Deoxyinosine

# Description:
Deoxyinosine is a nucleoside that is formed when hypoxanthine is attached to a deoxyribose ring (also known as a ribofuranose) via a beta-N9-glycosidic bond. Deoxyinosine is found in DNA while Inosine is found in RNA. Inosine is a nucleic acid important for RNA editing. Adenosine deaminase (ADA) catalyzes the conversion of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. ADA-deficient individuals suffer from severe combined immunodeficiency (SCID) and are unable to produce significant numbers of mature T or B lymphocytes. This occurs as a consequence of the accumulation of ADA substrates or their metabolites.   Inosine is also an intermediate in a chain of purine nucleotides reactions required for muscle movements.

# Synonyms:
2'-Deoxyinosine; 2deoxy-Inosine; 9-(2-Deoxy-b-D-erythro-pentofuranosyl)-1,9-dihydro-6H-purin-6-one; 9-(2-deoxy-b-D-erythro-pentofuranosyl)-Hypoxanthine; 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-Hypoxanthine; Deoxyinosine; d-Ino; 9-(2-Deoxy-beta-delta-erythro-pentofuranosyl)-1,9-dihydro-6H-purin-6-one; 9-(2-deoxy-beta-delta-erythro-pentofuranosyl)-Hypoxanthine; delta-Ino

# Chemical_IUPAC_Name:
9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one

# Chemical_Formula:
C10H12N4O4

# Chemical_Structure:
tbl_chemical:::HMDB00071_ZOOM.png:::119283172930298177

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00071_THUMB.png:::119283172710795829

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines; Nucleosides

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; primary alcohol; secondary alcohol; oxo(het)arene; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
252.08586

# Molecular_Weight_Avg:
252.22668

# Smiles_String_isomeric:
OC[C@H]1O[C@H](C[C@@H]1O)N2C=NC3=C2N=CN=C3O

# Smiles_String_canonical:
OCC1OC(CC1O)N2C=NC3=C2N=CN=C3O

# KEGG_Compound_ID:
C05512

# BioCyc_ID:
DEOXYINOSINE

# PubChem_CID:
65058

# PubChem_SID:
3139569; 7885197; 207012; 12035885; 7859; 8145150; 855080

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
45942

# Wikipedia_ID:
Not Available

# METLIN_ID:
3383

# Ref_ID:
825775; 10381167; 9495239; 8595732; 9920426; 10380753; 9463485

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
890-38-0

# InChI:
InChI=1/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1

# Synthesis_Reference:
Canadian Journal of Chemistry  (1973),  51(19),  3161-9.

# Melting_Point:
250 oC

# Melting_Point_predicted:
140.7 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
32.5 mg/mL [MEYLAN,WM et al. (1996)]; 18.7 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-1.71 [FORD,H ET AL. (1991)]

# LogP_predicted:
-1.62 [Predicted by ALOGPS]; -0.8 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Deoxyinosine.pdf:::1132562196584683306

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Deoxyinosine.mol:::1132723805062137317

# SDF_File_[Text]:
tbl_chemical:::HMDB00071.sdf:::119283172299280283

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00071.pdb:::119283172567051851

# PDB_ID:
1Z39

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1Z39.txt:::1132720900968872930

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::050117_P00_10_BA_1DP_presat_expanded_2.gif:::114460742231819839

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::050117_P00_10_BA_1DP_presat.zip:::1175124318871207283

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050117_P00_10_BA_1DP_Assigned.png:::114660083989380596

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Deoxyinosine.gif:::1132732105187434958

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00071_peaks.txt:::1156309526598969069

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Deoxyinosine_C.gif:::1132737674452351404

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00071_peaks.txt:::1156310716974568635

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00071L.png:::1175552630202670; Medium Energy:tbl_ms:::HMDB00071M.png:::117555268411084922; High Energy:tbl_ms:::HMDB00071H.png:::117555271697211786

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; nucleus; Extracellular

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	< 0.1	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	8595732
Blood	<0.1	uM	Adult:>18_yrs_old	Both	Normal	8595732


# Concentration_[Abnormal]:
Urine	3.2	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Purine Nucleoside Phosphorylase Deficiency	8595732
Blood	6.5	umol/L	Adult:>18_yrs_old	Both	Purine Nucleoside Phosphorylase Deficiency	8595732


# Associated_Disorders:
Purine Nucleoside Phosphorylase Deficiency

# Pathway_Names:
Purine metabolism;Nicotinate and nicotinamide metabolism

# Pathway_Images:
Purine_Synthesis.jpg;Nicotinamide_synthesis_(NADH).jpg

# KEGG_Images:
map00230;map00760

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;Nicotinamide_synthesis_(NADH)_Graph.jpg

# Pathway_SBMLs:
Purine_Synthesis.xml;Nicotinamide_synthesis_(NADH).xml

# Metabolic_Enzyme_1_ID:
5805

# Metabolic_Enzyme_1_Name:
Purine nucleoside phosphorylase

# Metabolic_Enzyme_1_Synonyms:
Inosine phosphorylase; PNP

# Metabolic_Enzyme_1_Gene_Name:
NP

# Metabolic_Enzyme_1_Protein_Sequence:
>Purine nucleoside phosphorylase
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS

# Metabolic_Enzyme_1_Number_of_Residues:
289

# Metabolic_Enzyme_1_Molecular_Weight:
32118

# Metabolic_Enzyme_1_Theoretical_pI:
6.95

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  purine-nucleoside phosphorylase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_1_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_1_Reaction:
purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00896:Mtap_PNP

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.2.1

# Metabolic_Enzyme_1_GenBank_ID_Protein:
35565

# Metabolic_Enzyme_1_SwissProt_ID:
PNPH_HUMAN (P00491)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
NP

# Metabolic_Enzyme_1_Geneatlas_id:
NP

# Metabolic_Enzyme_1_hgnc_id:
HGNC:7892

# Metabolic_Enzyme_1_PDB_ID:
1RT9

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>870 bp
ATGGAGAACGGATACACCTATGAAGATTATAAGAACACTGCAGAATGGCTTCTGTCTCAT
ACTAAGCACCGACCTCAAGTTGCAATAATCTGTGGTTCTGGATTAGGAGGTCTGACTGAT
AAATTAACTCAGGCCCAGATCTTTGACTACAGTGAAATCCCCAACTTTCCTCGAAGTACA
GTGCCAGGTCATGCTGGCCGACTGGTGTTTGGGTTCCTGAATGGCAGGGCCTGTGTGATG
ATGCAGGGCAGGTTCCACATGTATGAAGGGTACCCACTCTGGAAGGTGACATTCCCAGTG
AGGGTTTTCCACCTTCTGGGTGTGGACACCCTGGTAGTCACCAATGCAGCAGGAGGGCTG
AACCCCAAGTTTGAGGTTGGAGATATCATGCTGATCCGTGACCATATCAACCTACCTGGT
TTCAGTGGTCAGAACCCTCTCAGAGGGCCCAATGATGAAAGGTTTGGAGATCGTTTCCCT
GCCATGTCTGATGCCTACGACCGGACTATGAGGCAGAGGGCTCTCAGTACCTGGAAACAA
ATGGGGGAGCAACGTGAGCTACAGGAAGGCACCTATGTGATGGTGGCAGGCCCCAGCTTT
GAGACTGTGGCAGAATGTCGTGTGCTGCAGAAGCTGGGAGCAGACGCTGTTGGCATGAGT
ACAGTACCAGAAGTTATCGTTGCACGGCACTGTGGACTTCGAGTCTTTGGCTTCTCACTC
ATCACTAACAAGGTCATCATGGATTATGAAAGCCTGGAGAAGGCCAACCATGAAGAAGTC
TTAGCAGCTGGCAAACAAGCTGCACAGAAATTGGAACAGTTTGTCTCCATTCTTATGGCC
AGCATTCCACTCCCTGACAAAGCCAGTTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X00737

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_1_Locus:
14q13.1

# Metabolic_Enzyme_1_SNPs:
rs1049564; rs1130650; rs1049562; rs7785; rs1617940; rs1760940; rs1713420; rs1760935; rs1713422; rs1713421; rs3790064; rs3790065; rs1713429; rs17882804; rs17880405; rs1756369; rs12147688; rs8008133; rs17881431; rs17881345; rs7154909; rs17883821; rs17885781; rs1760934; rs17879107; rs17880844; rs17879913; rs17881184; rs17885714; rs17880480; rs17883253; rs17878900; rs1713426; rs17881356; rs1713427; rs1760933; rs3790062; rs17883795; rs17112168; rs17880290; rs12147906; rs17881554; rs17881206; rs1049700; rs17882836; rs12101049; rs17884106; rs12147035; rs34480769; rs3838361; rs3842517; rs1760939; rs17885917; rs17886095; rs1760938; rs17883294; rs17883604; rs8019880; rs17881280; rs35549071; rs35139440; rs17880503; rs7151666; rs10498268; rs1079375; rs1079376; rs11846743; rs11850059; rs11850069; rs12587218; rs12886203; rs12888804; rs12891271; rs13379232; rs13379234; rs1629478; rs17112384; rs17112385; rs1713459; rs1713460; rs1713461; rs1713462; rs17242655; rs17242662; rs17242669; rs1756365; rs1760930; rs1760931; rs1760941; rs1760942; rs2077153; rs2481768; rs35175606; rs35567022; rs7156659; rs755777

# Metabolic_Enzyme_1_General_References:
6087295; 3029074; 12928150; 2104852; 1384322; 8931706

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5806

# Metabolic_Enzyme_2_Name:
Thymidine phosphorylase precursor

# Metabolic_Enzyme_2_Synonyms:
TdRPase; TP; Platelet-derived endothelial cell growth factor; PD-ECGF; Gliostatin

# Metabolic_Enzyme_2_Gene_Name:
ECGF1

# Metabolic_Enzyme_2_Protein_Sequence:
>Thymidine phosphorylase precursor
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ

# Metabolic_Enzyme_2_Number_of_Residues:
482

# Metabolic_Enzyme_2_Molecular_Weight:
49956

# Metabolic_Enzyme_2_Theoretical_pI:
5.19

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  pyrimidine base metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis

# Metabolic_Enzyme_2_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_2_Reaction:
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF02885:Glycos_trans_3N;
PF00591:Glycos_transf_3;
PF07831:PYNP_C

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.4.2.4

# Metabolic_Enzyme_2_GenBank_ID_Protein:
189701

# Metabolic_Enzyme_2_SwissProt_ID:
TYPH_HUMAN (P19971)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ECGF1

# Metabolic_Enzyme_2_Geneatlas_id:
ECGF1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:3148

# Metabolic_Enzyme_2_PDB_ID:
1UOU

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>1449 bp
ATGGCAGCCTTGATGACCCCGGGAACCGGGGCCCCACCCGCGCCTGGTGACTTCTCCGGG
GAAGGGAGCCAGGGACTTCCCGACCCTTCGCCAGAGCCCAAGCAGCTCCCGGAGCTGATC
CGCATGAAGCGAGACGGAGGCCGCCTGAGCGAAGCGGACATCAGGGGCTTCGTGGCCGCT
GTGGTGAATGGGAGCGCGCAGGGCGCACAGATCGGGGCCATGCTGATGGCCATCCGACTT
CGGGGCATGGATCTGGAGGAGACCTCGGTGCTGACCCAGGCCCTGGCTCAGTCGGGACAG
CAGCTGGAGTGGCCAGAGGCCTGGCGCCAGCAGCTTGTGGACAAGCATTCCACAGGGGGT
GTGGGTGACAAGGTCAGCCTGGTCCTCGCACCTGCCCTGGCGGCATGTGGCTGCAAGGTG
CCAATGATCAGCGGACGTGGTCTGGGGCACACAGGAGGCACCTTGGATAAGCTGGAGTCT
ATTCCTGGATTCAATGTCATCCAGAGCCCAGAGCAGATGCAAGTGCTGCTGGACCAGGCG
GGCTGCTGTATCGTGGGTCAGAGTGAGCAGCTGGTTCCTGCGGACGGAATCCTATATGCA
GCCAGAGATGTGACAGCCACCGTGGACAGCCTGCCACTCATCACAGCCTCCATTCTCAGT
AAGAAACTCGTGGAGGGGCTGTCCGCTCTGGTGGTGGACGTTAAGTTCGGAGGGGCCGCC
GTCTTCCCCAACCAGGAGCAGGCCCGGGAGCTGGCAAAGACGCTGGTTGGCGTGGGAGCC
AGCCTAGGGCTTCGGGTCGCGGCAGCGCTGACCGCCATGGACAAGCCCCTGGGTCGCTGC
GTGGGCCACGCCCTGGAGGTGGAGGAGGCGCTGCTCTGCATGGACGGCGCAGGCCCGCCA
GACTTAAGGGACCTGGTCACCACGCTCGGGGGCGCCCTGCTCTGGCTCAGCGGACACGCG
GGGACTCAGGCTCAGGGCGCTGCCCGGGTGGCCGCGGCGCTGGACGACGGCTCGGCCCTT
GGCCGCTTCGAGCGGATGCTGGCGGCGCAGGGCGTGGATCCCGGTCTGGCCCGAGCCCTG
TGCTCGGGAAGTCCCGCAGAACGCCGGCAGCTGCTGCCTCGCGCCCGGGAGCAGGAGGAG
CTGCTGGCGCCCGCAGATGGCACCGTGGAGCTGGTCCGGGCGCTGCCGCTGGCGCTGGTG
CTGCACGAGCTCGGGGCCGGGCGCAGCCGCGCTGGGGAGCCGCTCCGCCTGGGGGTGGGC
GCAGAGCTGCTGGTCGACGTGGGTCAGAGGCTGCGCCGTGGGACCCCCTGGCTCCGCGTG
CACCGGGACGGCCCCGCGCTCAGCGGCCCGCAGAGCCGCGCCCTGCAGGAGGCGCTCGTA
CTCTCCGACCGCGCGCCATTCGCCGCCCCCTCGCCCTTCGCAGAGCTCGTTCTGCCGCCG
CAGCAATAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M63193

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_2_Locus:
22q13|22q13.33

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
2467210; 1570012; 1400349; 1590793; 9924029; 12177387

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5937

# Metabolic_Enzyme_3_Name:
Adenosine deaminase

# Metabolic_Enzyme_3_Synonyms:
Adenosine aminohydrolase

# Metabolic_Enzyme_3_Gene_Name:
ADA

# Metabolic_Enzyme_3_Protein_Sequence:
>Adenosine deaminase
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL

# Metabolic_Enzyme_3_Number_of_Residues:
363

# Metabolic_Enzyme_3_Molecular_Weight:
40765

# Metabolic_Enzyme_3_Theoretical_pI:
5.80

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  adenosine deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_3_Specific_Function:
Adenosine + H(2)O = inosine + NH(3)

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_3_Reaction:
adenosine + H2O = inosine + ammonia

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.5.4.4

# Metabolic_Enzyme_3_GenBank_ID_Protein:
28380

# Metabolic_Enzyme_3_SwissProt_ID:
ADA_HUMAN (P00813)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ADA

# Metabolic_Enzyme_3_Geneatlas_id:
ADA

# Metabolic_Enzyme_3_hgnc_id:
HGNC:186

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_3_Gene_Sequence:
>1092 bp
ATGGCCCAGACGCCCGCCTTCGACAAGCCCAAAGTAGAACTGCATGTCCACCTAGACGGA
TCCATCAAGCCTGAAACCATCTTATACTATGGCAGGAGGAGAGGGATCGCCCTCCCAGCT
AACACAGCAGAGGGGCTGCTGAACGTCATTGGCATGGACAAGCCGCTCACCCTTCCAGAC
TTCCTGGCCAAGTTTGACTACTACATGCCTGCTATCGCGGGCTGCCGGGAGGCTATCAAA
AGGATCGCCTATGAGTTTGTAGAGATGAAGGCCAAAGAGGGCGTGGTGTATGTGGAGGTG
CGGTACAGTCCGCACCTGCTGGCCAACTCCAAAGTGGAGCCAATCCCCTGGAACCAGGCT
GAAGGGGACCTCACCCCAGACGAGGTGGTGGCCCTAGTGGGCCAGGGCCTGCAGGAGGGG
GAGCGAGACTTCGGGGTCAAGGCCCGGTCCATCCTGTGCTGCATGCGCCACCAGCCCAAC
TGGTCCCCCAAGGTGGTGGAGCTGTGTAAGAAGTACCAGCAGCAGACCGTGGTGGCCATT
GACCTGGCTGGAGATGAGACCATCCCAGGAAGCAGCCTCTTGCCTGGACATGTCCAGGCC
TACCAGGAGGCTGTGAAGAGCGGCATTCACCGTACTGTCCACGCCGGGGAGGTGGGCTCG
GCCGAAGTAGTAAAAGAGGCTGTGGACATACTCAAGACAGAGCGGCTGGGACACGGCTAC
CACACCCTGGAAGACCAGGCCCTTTATAACAGGCTGCGGCAGGAAAACATGCACTTCGAG
ATCTGCCCCTGGTCCAGCTACCTCACTGGTGCCTGGAAGCCGGACACGGAGCATGCAGTC
ATTCGGCTCAAAAATGACCAGGCTAACTACTCGCTCAACACAGATGACCCGCTCATCTTC
AAGTCCACCCTGGACACTGATTACCAGATGACCAAACGGGACATGGGCTTTACTGAAGAG
GAGTTTAAAAGGCTGAACATCAATGCGGCCAAATCTAGTTTCCTCCCAGAAGATGAAAAG
AGGGAGCTTCTCGACCTGCTCTATAAAGCCTATGGGATGCCACCTTCAGCCTCTGCAGGG
CAGAACCTCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X02994

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_3_Locus:
20q12-q13.11

# Metabolic_Enzyme_3_SNPs:
rs244076; rs11906526; rs427224; rs244078; rs2299686; rs2224999; rs379863; rs8119702; rs8119756; rs244075; rs2299691; rs2007515; rs2057637; rs762539; rs447833; rs2057638; rs6031682; rs6031690; rs6031686; rs2299688; rs6031689; rs371927; rs244079; rs2007720; rs1799880; rs2299692; rs395209; rs399159; rs2299690; rs11700291; rs929089; rs406383; rs2057639; rs967807; rs244073; rs2299694; rs452159; rs2157436; rs6031693; rs2299687; rs6017375; rs446125; rs2477898; rs6103795; rs6017378; rs445170; rs6031685; rs765215; rs6031695; rs1810751; rs2299697; rs433875; rs6031688; rs6094011; rs765216; rs244072; rs6031687; rs2299689; rs427483; rs427499; rs11907906; rs12480490; rs6103803; rs6031697; rs6017371; rs6031678; rs375379; rs384851; rs395896; rs450043; rs6094005; rs6031679; rs11698539; rs389308; rs11086932; rs6103804; rs6065738; rs1042360; rs11555566; rs7344760; rs6031698; rs394105; rs36216718; rs5841559; rs34853885; rs6017373; rs34665505; rs2765290; rs3831638; rs35553416; rs2515692; rs6031694; rs6103801; rs6103792; rs36222732; rs10561362; rs6103799; rs35009045; rs6094008; rs2007704; rs11474041; rs6103794; rs445725; rs11905649; rs6017376; rs457669; rs35383274; rs6103796; rs368253; rs6130653; rs6031691; rs11468750; rs8118045; rs6094004; rs455368; rs11484279; rs6031696; rs912912; rs6103800; rs6031684; rs445856; rs6094007; rs6017377; rs755144; rs6094009; rs11481765; rs382464; rs6103789; rs35712615; rs404898; rs6124654; rs929088; rs6031692; rs35863085; rs414146; rs6031681; rs413816; rs6103790; rs6031683; rs35436165; rs35935728; rs11698497; rs11373171; rs3091476; rs36013790; rs5841560; rs11907079; rs6103793; rs34344438; rs6017374; rs34081313; rs35535317; rs6130651; rs7353732; rs11484329; rs3041775; rs451499; rs3787359; rs11476459; rs7262528; rs6103797; rs34225524; rs11480982; rs34830340; rs6094010; rs6094006; rs3787360; rs6073497; rs11473840; rs13036408; rs34044957; rs244074; rs6103788; rs6017372; rs386512; rs35483396; rs11468701; rs2299695; rs244077; rs35505353; rs36102321; rs35545345; rs6103802; rs6103791; rs6103798; rs3831639; rs34833873; rs35784536; rs35587028; rs420183; rs6130652; rs10645831; rs36216716; rs435679; rs36216717; rs6031700; rs35153391; rs1061662; rs11699718; rs1886849; rs2071878; rs2148040; rs244081; rs244082; rs244086; rs244087; rs2664524; rs2664557; rs2664560; rs2664582; rs2664585; rs2868116; rs3180636; rs4810427; rs4810428; rs6017369; rs6031673; rs6031674; rs6031675; rs6031676; rs6031677; rs6031702; rs6031704; rs6065739; rs6094001; rs6094002; rs6094003; rs6094016; rs6094017; rs6103786; rs6103787; rs6103805; rs6103806; rs6130650; rs6130654; rs7266968; rs8118020; rs927784

# Metabolic_Enzyme_3_General_References:
6090454; 6546794; 3839456; 3028473; 11780052; 6688808; 8031011; 6208479; 3839802; 3182793; 2783588; 1284479; 8227344; 8299233; 8589684; 7599635; 9225964

# Metabolic_Enzyme_3_References:
Not Available

End of HMDB00071

Beginning of HMDB00072
# Accession_No:
HMDB00072

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-14 11:51:53

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
cis-Aconitic acid

# Description:
An intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.   The enzyme aconitase (aconitate hydratase; EC 4.2.1.3) catalyses the stereo-specific isomerization of citrate to isocitrate via cis-aconitate in the tricarboxylic acid cycle

# Synonyms:
(1Z)-1-Propene-1,2,3-tricarboxylate; (1Z)-1-Propene-1,2,3-tricarboxylic acid; (Z)-1-Propene-1,2,3-tricarboxylate; (Z)-1-Propene-1,2,3-tricarboxylic acid; (Z)-Aconitate; (Z)-Aconitic acid; 1,cis-2,3-Propenetricarboxylate; 1,cis-2,3-Propenetricarboxylic acid; 1-propene-1,2,3-tricarboxylate; 1-propene-1,2,3-tricarboxylic acid; cis-1-Propene-1,2,3-tricarboxylate; cis-1-Propene-1,2,3-tricarboxylic acid; cis-Aconate; cis-Aconic acid; cis-Aconitate; cis-Aconitic acid; cis-Oxaloacetate; cis-Oxaloacetic acid

# Chemical_IUPAC_Name:
prop-1-ene-1,2,3-tricarboxylic acid

# Chemical_Formula:
C6H6O6

# Chemical_Structure:
tbl_chemical:::HMDB00072_ZOOM.png:::119283173846247594

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00072_THUMB.png:::119283173647734292

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
carboxylic acid; alkene

# Taxonomy_Biofunction:
Component of Glyoxylate and dicarboxylate metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
174.01645

# Molecular_Weight_Avg:
174.10825

# Smiles_String_isomeric:
OC(=O)CC(=CC(O)=O)C(O)=O

# Smiles_String_canonical:
OC(=O)CC(=CC(O)=O)C(O)=O

# KEGG_Compound_ID:
C00417

# BioCyc_ID:
CIS-ACONITATE

# PubChem_CID:
309

# PubChem_SID:
3707; 73450; 2239; 11377557; 11366833; 11487235; 8146966; 10320870; 11364271; 11375326; 132105; 11491163; 11493558; 11489604; 11459578; 11372454; 11369395; 5596505; 11495191; 11485451; 11361833; 11341650; 2345; 5390; 11446031; 11457546

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Not Available

# METLIN_ID:
5130

# Ref_ID:
9781360; 813176; 14708889; 8087979; 9693263; 8738428; 8151077

# ChEBI_ID:
32805

# CAS_Registry_Number:
585-84-2

# InChI:
InChI=1/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/b3-1-

# Synthesis_Reference:
Aconitic acid.     Bruce, Wm. F.    Organic Syntheses  (1937),  17  1-3.

# Melting_Point:
125 oC

# Melting_Point_predicted:
39.2 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
400.0 mg/mL [BEILSTEIN]

# H2O_Solubility_Predicted:
6.72 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-0.40 [Predicted by ALOGPS]; -1.1 [Predicted by PubChem via XLOGP]; -0.14 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::cis-Aconitic_acid.mol:::1132723805140518595

# SDF_File_[Text]:
tbl_chemical:::HMDB00072.sdf:::119283173322416947

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00072.pdb:::119283173511161262

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::050122_P00_02_IS_1DP_presat.png:::114859000296894739

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::050122_P00_02_IS_1DP_presat.zip:::114859000297653640

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::050122_P00_02_IS_1DP_Assigned.png:::115636844881141698

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050122_P00_02_IS_2DHSQC_554.png:::114789922251828277

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050122_P00_02_IS_2DHSQC_554.zip:::114789922287863704

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050122_P00_02_IS_2DHSQC_554_Assigned.png:::115083366320662543

# Predicted_H_NMR_Spectrum:
tbl_chemical:::cis-Aconitic acid.gif:::1132732105406965217

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00072_peaks.txt:::1156309527638220681

# Predicted_C_NMR_Spectrum:
tbl_chemical:::cis-Aconitic acid_C.gif:::113273767505218610

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00072_peaks.txt:::1156310718000921239

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00072L.png:::117555263501856768; Medium Energy:tbl_ms:::HMDB00072M.png:::117555268821193634; High Energy:tbl_ms:::HMDB00072H.png:::117555272017972540

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
CSF; Urine

# Concentration_[Normal]:
Urine	67.9	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	8087979
Urine	73.8	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	8087979
Urine	40.8	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	37.9	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	29.8	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	8087979
Urine	54.5 (32.4-76.6)	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	14708889
Cerebrospinal_Fluid(CSF)	20.0 (13.0-27.0)	umol/L	Adult:>18_yrs_old	Both	Normal	9693263


# Concentration_[Abnormal]:
Urine	32.0 (0.0-70.0)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Lung Cancer	HMP experimental


# Associated_Disorders:
Cachexia; Friedreich Ataxia; Huntington's Disease; Hypercitraturia; Hypocitraturia; Lung Cancer; Parkinson's Disease

# Pathway_Names:
Glyoxylate and dicarboxylate metabolism;Reductive carboxylate cycle (CO2 fixation)

# Pathway_Images:
;

# KEGG_Images:
map00630;map00720

# Pathway_Graphs:
;

# Pathway_SBMLs:
;

# Metabolic_Enzyme_1_ID:
6000

# Metabolic_Enzyme_1_Name:
Aconitate hydratase, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
Citrate hydro-lyase; Aconitase

# Metabolic_Enzyme_1_Gene_Name:
ACO2

# Metabolic_Enzyme_1_Protein_Sequence:
>Aconitate hydratase, mitochondrial precursor
MAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRLN
RPLTLSEKIV
YGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVA
VPSTIHCDHLIEAQVGGEKDL
RRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIIL
ENYAYPGVLLIGTDSHTPNGGGLGGICIGVGG
ADAVDVMAGIPWELKCPKVIGVKLTGS
LSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGM
ATICNMGAEIGATTSV
FPYNHRMKKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHIN
GPFTP
DLAHPVAEVGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFT
ITPGS
EQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNR
NFTGRNDANPETHAFV
TSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELP
KGEFDPGQDTYQHPPKDSSGQHVDVSP
TSQRLQLLEPFDKWDGKDLEDLQILIKVKGKC
TTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKAN
SVRNAVTQEFGPVPDTARYYK
KHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLK
KQGLLPLTFA
DPADYNKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGS

ALNRMKELQQ

# Metabolic_Enzyme_1_Number_of_Residues:
780

# Metabolic_Enzyme_1_Molecular_Weight:
85426

# Metabolic_Enzyme_1_Theoretical_pI:
7.65

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  aconitate hydratase activity
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-oxygen lyase activity
Function:  hydro-lyase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
 ||
>>>
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  mitochondrion

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
Citrate = cis-aconitate + H(2)O

# Metabolic_Enzyme_1_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00630  Glyoxylate and dicarboxylate metabolism;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_1_Reaction:
citrate = cis-aconitate + H2O

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00330:Aconitase;
PF00694:Aconitase_C

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 4.2.1.3

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1718502

# Metabolic_Enzyme_1_SwissProt_ID:
ACON_HUMAN (Q99798)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ACO2

# Metabolic_Enzyme_1_Geneatlas_id:
ACO2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:118

# Metabolic_Enzyme_1_PDB_ID:
1B0J

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_1_Gene_Sequence:
>2343 bp

ATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTA
CCATGTGGCCT
CAGTCCTGTGCCAACGGGCCAAGGTGGCGATGACGCATTTTGAGCCCA
ACGAGTACATCCATTATGACCT
GCTAGAGAAGAACATTAACATTGTTCGCAAACGACTG
AACCGGCCGCTGACACTCTCGGAGAAGATTGTG
TATGGACACCTGGATGACCCCGCCAG
CCAGGAAATTGAGCGAGGCAAGTCGTACCTGCGGCTGCGGCCCG
ACCGTGTGGCCATGC
AGGATGCGACGGCCCAGATGGCCATGCTCCAGTTCATCAGCAGCGGGCTGTCCAA
GGTG
GCTGTGCCATCCACCATCCACTGTGACCATCTGATTGAAGCCCAGGTTGGGGACGAGAAA
GACCTG
CGCCGGGCCAAGGACATCAACCAGGAAGTTTATAATTTCCTGGCAACTGCAGG
TGACAAGTATGGCGTGG
GCTTCTGGAGCCCTGGATCTGGAATCATTCACCAGATTATTC
TCGAAAACTATGCGTACCCTGGAGTTCT
TCTGATTGGAACTGACTCCCACACCCCCAAT
GGTGGTGGCCTAGGAGGCATCTGCATTGGAGTAGGGGGT
GCAGATGCTGTGGATGTCAT
GGCTGGGATCCCCTGGGAGCTGAAGTGCCCCAAGGTGATTGGCGTGAAGC
TGACGGGCT
CTCTCTCCGGTTGGACCTCACCCAAAGATGTGATCCTGAAGGTGGCAGGCATCCTCACGG
T
GAAAGGTGGCACAGGTGCAATCGTGGAATACCACGGGCCTGGTGTAGACTCCATGTCC
TGCACTGGCATG
GCGACAATCTGCAACATGGGTGCAGAAATTGGGGCCACCACTTCCGT
GTTCCCTTACAACCACAGGATGA
AGAAGTACCTGAGCAAGACCGGCCGGGAAGACATTG
CCAATCTAGCTGATGAATTCAAGGATCACTTGGT
GCCTGACCCTGGCTGCCATTATGAC
CAACTAATTGAAATTAACCTCAGTGAGCTGAAGCCACACATCAAT
GGGCCCTTCACCCC
TGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAGAAGGAAGGATGGC
CTC
TGGACATCCGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGC
GCTCAGC
AGCTGTGGCCAAGCAGGCACTGGCCCATGGACTCAAGTGCAAGTCCCAGTTC
ACCATCACTCCAGGTTCC
GAGCAGATCCGCGCCACCATTGAGCGGGACGGCTATGCACA
GATCCTGAGGGATCTGGGTGGCATTGTCC
TGGCCAATGCCTGCGGGCCCTGCATTGGCC
AGTGGGACAGAAAGGACATCAAGAAGGGGGAGAAGAACAC
AATCGTCACCTCCTACAAC
AGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTTGTC
ACGTCCCC
AGAGATTGTCACAGCCCTGGCCATTGCAGGAACCCTCAAGTTCAACCCAGAGACCGACTA
CC
TGACAGGCAAGGATGGCAAGAAGTTCAGGCTGGAAGCTCCGGATGCAGATGAGCTTC
CCAAAGGGGAGTT
TGACCCAGGGCAGGACACCTACCAGCACCCCCCAAAGGACAGCAGC
AGGCAGCATGTGGACGTGAGCCCC
ACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGA
CAAGTGGGATGGCAAGGACCTGGAGGACCTGCAGA
TCCTCATCAAGGTCAAAGGGAAGT
GTACCACTGACCACATCTCAGCTGCTGGCCCCTGGCTCAAGTTCCG
TGGGCACTTGGAT
AACATCTCCAACAACCTGCTCATTGGTGCCATCAACATTGAAAACGGCAAGGCCAAC
TC
CGTGCGCAATGCCGTCACTCAGGAGTTTGGCCCCGTCCCTGACACTGCCCGCTACTACAA
GAAACATG
GCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCGAGCC
GGGAGCATGCAGCTCTGGA
GCCTCGCCACCTTGGGGGCCGGGCCATCATCACCAAGAGC
TTTGCCAGGATCCACGAGACCAACCTGAAG
AAACAGGGCCTGCTGCCTCTGACCTTCGC
TGACCCGGCTGACTACAACAAGATTCACCCTGTGGACAAGC
TGACCATTCAGGGCCTGA
AGGACTTCACCCCTGGCAAGCCCCTGAAGTGCATCATCAAGCACCCCAACGG
GACCCAG
GAGACCATCCTCCTGAACCACACCTTCAACGAGACGCAGATTGAGTGGTTCCGCGCTGGC
AGT
GCCCTCAACAGAATGAAGGAACTGCAACAGTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U80040

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_1_Locus:
22q11.2-q13.31|22q13.2-q13.31

# Metabolic_Enzyme_1_SNPs:
rs137831; rs1799932; rs203320; rs169361; rs2284080; rs1960182; rs6519256; rs6519257; rs203319; rs12167184; rs5751114; rs12484694; rs2267434; rs2076196; rs12165815; rs6002390; rs2267433; rs5751117; rs9619974; rs9623409; rs79013; rs2267432; rs9611602; rs3827359; rs9623412; rs2413647; rs2267435; rs79011; rs9623411; rs2413645; rs2076199; rs727563; rs6002392; rs203318; rs11090049; rs11705190; rs3045391; rs7290434; rs738140; rs2284081; rs17002483; rs203317; rs8136366; rs1569516; rs17367716; rs7288661; rs9611603; rs7289999; rs202612; rs202610; rs11912852; rs2413646; rs9611604; rs17002487; rs7290508; rs137830; rs5758375; rs2267436; rs12170066; rs9607809; rs9611598; rs5758380; rs2006715; rs11554470; rs17856753; rs1049860; rs1049856; rs17852363; rs1049859; rs11554469; rs1049852; rs1049857; rs17852364; rs5758376; rs28634007; rs9611599; rs13054766; rs5751116; rs35732387; rs36024770; rs8185004; rs6002398; rs5758373; rs3838162; rs760810; rs5751115; rs34344341; rs9607807; rs5996034; rs34289556; rs137832; rs35052987; rs11331024; rs5845502; rs10639444; rs34646526; rs5758374; rs5758372; rs34309135; rs9680659; rs12166976; rs34770725; rs28407070; rs13056499; rs6002396; rs5751113; rs5758371; rs9607808; rs33914175; rs34337889; rs9623407; rs35192350; rs9607810; rs8141415; rs34893746; rs36062011; rs35664977; rs5758379; rs41281289; rs11372053; rs9680658; rs13342919; rs12628178; rs8139104; rs8141184; rs5758370; rs34610631; rs34433589; rs5845503; rs35435675; rs33969654; rs7287931; rs203321; rs9611605; rs9680628; rs34571918; rs34563140; rs5758377; rs35902787; rs9680631; rs34759958; rs7286459; rs41276321; rs9623410; rs34487526; rs9680629; rs2102246; rs137829; rs35270250; rs9623408; rs34742939; rs11705367; rs202609; rs9680630; rs34491448; rs9680654; rs35849502; rs35948127; rs4510317; rs8184972; rs28620979; rs34342736; rs28488294; rs35891403; rs5845504; rs35087813; rs3045393; rs34527134; rs34805234; rs34957102; rs1042972; rs10483211; rs12160340; rs12168565; rs17367849; rs1810460; rs1810461; rs188058; rs19573; rs2008065; rs202631; rs203313; rs203315; rs203316; rs2076197; rs2076198; rs2267430; rs2267431; rs34057431; rs34340787; rs35463585; rs4822032; rs4822034; rs505533; rs5751108; rs5758365; rs5758368; rs5758381; rs5758384; rs79009; rs9611597; rs9611606

# Metabolic_Enzyme_1_General_References:
9630632; 10591208

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6001

# Metabolic_Enzyme_2_Name:
Iron-responsive element-binding protein 1

# Metabolic_Enzyme_2_Synonyms:
IRE-BP 1; Iron regulatory protein 1; IRP1; Ferritin repressor protein; Aconitate hydratase; Citrate hydro-lyase; Aconitase

# Metabolic_Enzyme_2_Gene_Name:
ACO1

# Metabolic_Enzyme_2_Protein_Sequence:
>Ironresponsive elementbinding protein 1
MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDI
ENILHWNVTQ
HKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCP
ADLVIDHSIQVDFNRRADSLQ
KNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIH
QVNLEYLARVVFDQDGYYYPDSLVGTDSHTTM
IDGLGILGWGVGGIEAEAVMLGQPISM
VLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEF
FGPGVAQLSIADRATI
ANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPS
QDPDF
TQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTF
IYDNT
EFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPG
SGVVTYYLQESGVMPY
LSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLS
GNRNFEGRVHPNTRANYLASPPLVIAY
AIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPT
RDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPS
DKLFFWNSKSTYIKSPPFFEN
LTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRG
LTPREFNSYG
SRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLA

GKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGL
TGQERYTIIIP
ENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMA
K

# Metabolic_Enzyme_2_Number_of_Residues:
889

# Metabolic_Enzyme_2_Molecular_Weight:
98400

# Metabolic_Enzyme_2_Theoretical_pI:
6.66

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  aconitate hydratase activity
Function:  nucleic acid binding
Function:  RNA binding
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-oxygen lyase activity
Function:  hydro-lyase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
This protein also expresses aconitase activity

# Metabolic_Enzyme_2_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00630  Glyoxylate and dicarboxylate metabolism;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_2_Reaction:
citrate = cis-aconitate + H2O

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00330:Aconitase;
PF00694:Aconitase_C

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 4.2.1.3

# Metabolic_Enzyme_2_GenBank_ID_Protein:
33963

# Metabolic_Enzyme_2_SwissProt_ID:
IREB1_HUMAN (P21399)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ACO1

# Metabolic_Enzyme_2_Geneatlas_id:
ACO1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:117

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>2670 bp

ATGAGCAACCCATTCGCACACCTTGCTGAGCCATTGGATCCTGTACAACCAGGAAAGAA
ATTCTTCAATT
TGAATAAATTGGAGGATTCAAGATATGGGCGCTTACCATTTTCGATCA
GAGTTCTTCTGGAAGCAGCCAT
TCGGAATTGTGATGAGTTTTTGGTGAAGAAACAGGAT
ATTGAAAATATTCTACATTGGAATGTCACTCAG
CACAAGAACATAGAAGTGCCATTTAA
GCCTGCTCGTGTCATCCTGCAGGACTTTACGGGTGTGCCCGCTG
TGGTTGACTTTGCTG
CAATGCGTGATGCTGTGAAAAAGTTAGGAGGAGATCCAGAGAAAATAAACCCTGT
CTGC
CCTGCTGATCTTGTAATAGATCATTCCATCCAGGTTGATTTCAACAGAAGGGCAGACAGT
TTACAG
AAGAATCAAGACCTGGAATTTGAAAGAAATAGAGAGCGATTTGAATTTTTAAA
GTGGGGTTCCCAGGCTT
TTCACAACATGCGGATTATTCCCCCTGGCTCAGGAATCATCC
ACCAGGTGAATTTGGAATATTTGGCAAG
AGTGGTATTTGATCAGGATGGATATTATTAC
CCAGACAGCCTCGTGGGCACAGACTCGCACACTACCATG
ATTGATGGCTTGGGCATTCT
TGGTTGGGGTGTCGGTGGTATTGAAGCAGAAGCTGTCATGCTGGGTCAGC
CAATCAGTA
TGGTGCTTCCTCAGGTGATTGGCTACAGGCTGATGGGGAAGCCCCACCCTCTGGTAACAT
C
CACTGACATCGTGCTCACCATTACCAAGCACCTCCGCCAGGTTGGGGTAGTGGGCAAA
TTTGTCGAGTTC
TTCGGGCCTGGAGTAGCCCAGTTGTCCATTGCTGACCGAGCTACGAT
TGCTAACATGTGTCCAGAGTACG
GAGCAACTGCTGCCTTTTTCCCAGTTGATGAAGTTA
GTATCACGTACCTGGTGCAAACAGGTCGTGATGA
AGAAAAATTAAAGTATATTAAAAAA
TATCTTCAGGCTGTAGGAATGTTTCGAGATTTCAATGACCCTTCT
CAAGACCCAGACTT
CACCCAGGTTGTGGAATTAGATTTGAAAACAGTAGTGCCTTGCTGTAGTGGACCCA
AAA
GGCCTCAGGACAAAGTTGCTGTGTCCGACATGAAAAAGGACTTTGAGAGCTGCCTTGGAG
CCAAGCA
AGGATTTAAAGGATTCCAAGTTGCTCCTGAACATCATAATGACCATAAGACC
TTTATCTATGATAACACT
GAATTCACCCTTGCTCATGGTTCTGTGGTCATTGCTGCCAT
TACTAGCTGCACAAACACCAGTAATCCGT
CTGTGATGTTAGGGGCAGGATTGTTAGCAA
AGAAAGCTGTGGATGCTGGCCTGAACGTGATGCCTTACAT
CAAAACTAGCCTGTCTCCT
GGGAGTGGCGTGGTCACCTACTACCTACAAGAAAGCGGAGTCATGCCTTAT
CTGTCTCA
GCTTGGGTTTGACGTGGTGGGCTATGGCTGCATGACCTGCATTGGCAACAGTGGGCCTTT
AC
CTGAACCTGTGGTAGAAGCCATCACACAGGGAGACCTTGTAGCTGTTGGAGTACTAT
CTGGAAACAGGAA
TTTTGAAGGTCGAGTTCACCCCAACACCCGGGCCAACTATTTAGCC
TCTCCCCCCTTAGTAATAGCATAT
GCAATTGCTGGAACCATCAGAATCGACTTTGAGAA
AGAGCCATTGGGAGTAAATGCAAAGGGACAGCAGG
TATTTCTGAAAGATATCTGGCCGA
CTAGAGACGAGATCCAGGCAGTGGAGCGTCAGTATGTCATCCCGGG
GATGTTTAAGGAA
GTCTATCAGAAAATAGAGACTGTGAATGAAAGCTGGAATGCCTTAGCAACCCCATCA
GA
TAAGCTGTTTTTCTGGAATTCCAAATCTACGTATATCAAATCACCACCATTCTTTGAAAA
CCTGACTT
TGGATCTTCAGCCCCCTAAATCTATAGTGGATGCCTATGTGCTGCTAAATT
TGGGAGATTCGGTAACAAC
TGACCACATCTCCCCAGCTGGAAATATTGCAAGAAACAGT
CCTGCTGCTCGCTACTTAACTAACAGAGGC
CTAACTCCACGAGAATTCAACTCCTATGG
CTCCCGCCGAGGTAATGACGCCGTCATGGCACGGGGAACAT
TTGCCAACATTCGCTTGT
TAAACAGATTTTTGAACAAGCAGGCACCACAGACTATCCATCTGCCTTCTGG
GGAAATC
CTTGATGTGTTTGATGCTGCTGAGCGGTACCAGCAGGCAGGCCTTCCCCTGATCGTTCTG
GCT
GGCAAAGAGTACGGTGCAGGCAGCTCCCGAGACTGGGCAGCTAAGGGCCCTTTCCT
GCTGGGAATCAAAG
CCGTCCTGGCCGAGAGCTACGAGCGCATTCACCGCAGTAACCTGG
TTGGGATGGGTGTGATCCCACTTGA
ATATCTCCCTGGTGAGAATGCAGATGCCCTGGGG
CTCACAGGGCAAGAACGATACACTATCATTATTCCA
GAAAACCTCAAACCACAAATGAA
AGTCCAGGTCAAGCTGGATACTGGCAAGACCTTCCAGGCTGTCATGA
GGTTTGACACTG
ATGTGGAGCTCACTTATTTCCTCAACGGGGGCATCCTCAACTACATGATCCGCAAGAT
G
GCCAAGTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
Z11559

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_2_Locus:
9p22-q32|9p22-p13

# Metabolic_Enzyme_2_SNPs:
rs34630459; rs3780473; rs34319839; rs35370505; rs1041321; rs4495514; rs7028085; rs882812; rs1028932; rs7033149; rs6476361; rs5005316; rs7028748; rs913762; rs10813809; rs10813808; rs1041320; rs12985; rs10970952; rs10738885; rs7847742; rs10970961; rs10813810; rs7873764; rs10813805; rs7866419; rs4297112; rs1854529; rs10970953; rs12551359; rs7850888; rs10813807; rs11787823; rs10970951; rs11999526; rs1854530; rs10117433; rs7034950; rs13302577; rs7037696; rs7873763; rs11999515; rs10813806; rs1556138; rs2026739; rs1467712; rs10970971; rs10813813; rs7026133; rs10435797; rs11793098; rs10813818; rs10511906; rs10758139; rs7022554; rs4878497; rs10813815; rs4879583; rs10970978; rs10738886; rs4442231; rs7874815; rs10123372; rs12001953; rs10970965; rs3814520; rs10970975; rs13290492; rs16918276; rs3814521; rs12555576; rs7855113; rs2375965; rs3780474; rs4879584; rs10813816; rs7019520; rs2068116; rs2026740; rs16918256; rs7032871; rs4879586; rs10758138; rs17288067; rs13293491; rs1467713; rs10970972; rs7855756; rs10970977; rs10970980; rs7037425; rs16918278; rs12379278; rs2274721; rs13292540; rs10813811; rs10970969; rs12554703; rs12238573; rs10970976; rs7874563; rs10970966; rs10738887; rs10970973; rs7871750; rs10813817; rs10970974; rs10813814; rs10970964; rs10970981; rs7043497; rs7042042; rs879450; rs867469; rs41304757; rs41305321; rs41306075; rs7025336; rs3814519; rs41313772; rs41272905; rs35706646; rs35610417; rs28445290; rs11789907; rs4324989; rs36073023; rs10970962; rs5897504; rs13294666; rs10970983; rs9721741; rs7040354; rs10970957; rs7027161; rs7049187; rs10970960; rs7033829; rs11424780; rs7049207; rs11318235; rs34173205; rs28667096; rs10758137; rs34758664; rs3085083; rs10970958; rs12338370; rs10713644; rs4634749; rs10758136; rs35547790; rs7020247; rs10970954; rs7854312; rs7847310; rs7031833; rs7851054; rs7018811; rs1064254; rs10970959; rs35241313; rs5897505; rs1136983; rs41314201; rs34915528; rs35631511; rs10970968; rs35495030; rs4492457; rs34268383; rs41298178; rs41272903; rs7868221; rs34178844; rs10970982; rs34617908; rs11315726; rs34256711; rs13283002; rs34533705; rs10970970; rs34070326; rs7035134; rs35294620; rs35429291; rs1136984; rs35503711; rs35639058; rs34738086; rs10123298; rs12350422; rs35612832; rs7046460; rs34888676; rs7859209; rs34715465; rs34941863; rs7863494; rs12350423; rs12003969; rs7469941; rs11282433; rs34854756; rs13288806; rs7875458; rs11421318; rs9695206; rs34680934; rs16918197; rs5023816; rs16918200; rs34115683; rs34176026; rs35460166; rs1023085; rs1023087; rs1052803; rs10738888; rs10738889; rs10738890; rs10758135; rs10813801; rs10813802; rs10813803; rs10970947; rs10970949; rs10970985; rs10970986; rs10970987; rs10970988; rs1133071; rs12006123; rs12236816; rs12237410; rs12551294; rs12555727; rs1360171; rs17288004; rs17288914; rs17289116; rs3205166; rs35210922; rs35253851; rs36046033; rs7044329; rs7047398; rs7857128; rs7865082; rs9792540

# Metabolic_Enzyme_2_General_References:
1738601; 2172968; 1903202; 1946430

# Metabolic_Enzyme_2_References:
Not Available

End of HMDB00072

Beginning of HMDB00073
# Accession_No:
HMDB00073

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-22 12:21:53

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Dopamine

# Description:
Dopamine is a member of the catecholamine (Neurotransmitters) family in the brain, and is a precursor to epinephrine (adrenaline) and norepinephrine (noradrenaline).   Dopamine is synthesized in the body (mainly by nervous tissue and adrenal glands) first by the hydration of the amino acid tyrosine to DOPA by tyrosine hydroxylase and then by the decarboxylation of DOPA by aromatic-L-amino-acid decarboxylase. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (Dopamine receptors) mediates its action. --PubChem

# Synonyms:
2-(3,4-Dihydroxyphenyl)ethylamine; 3,4-Dihydroxyphenethylamine; 3,4-Dihydroxyphenylethylamine; 3-Hydroxytyramine; 3-Hydroxytyramine hydrochloride; 4-(2-Aminoethyl)-1,2-benzenediol; 4-(2-Aminoethyl)catechol; 4-(2-Aminoethyl)pyrocatechol; 4-(2-Aminoethyl)pyrocatechol hydrochloride; 4-(2-aminoethyl)-1,2-Benzenediol hydrochloride; 4-(2-aminoethyl)-Pyrocatechol; 4-(2-aminoethyl)-Pyrocatechol hydrochloride; Dopamin; Dopamine; Dopamine hydrochloride; Dopaminum; Dopastat; Dophamine; Dynatra; Hydroxytyramin; Intropin; Oxytyramine; Revivan; a-(3,4-Dihydroxyphenyl)-b-aminoethane; alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane; beta-(3,4-Dihydroxyphenyl)ethylamine hydrochloride; deoxyepinephrine; hydroxytyramine; m-Hydroxytyramine hydrochloride

# Chemical_IUPAC_Name:
4-(2-aminoethyl)benzene-1,2-diol

# Chemical_Formula:
C8H11NO2

# Chemical_Structure:
tbl_chemical:::HMDB00073_ZOOM.png:::119283174715248178

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00073_THUMB.png:::119283174555731336

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Catecholamines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
phenol or hydroxyhetarene; 1,2-diphenol; primary amine; primary aliphatic amine (alkylamine); aromatic compound

# Taxonomy_Biofunction:
Component of Tyrosine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
153.07898

# Molecular_Weight_Avg:
153.17844

# Smiles_String_isomeric:
NCCC1=CC=C(O)C(O)=C1

# Smiles_String_canonical:
NCCC1=CC=C(O)C(O)=C1

# KEGG_Compound_ID:
C03758

# BioCyc_ID:
DOPAMINE

# PubChem_CID:
681

# PubChem_SID:
562742; 6517; 11363906; 8145174; 11370018; 7888623; 2667; 840958; 11373057; 836354; 11361194; 11494826; 11534314; 11484941; 11364894; 794678; 11378187; 148617; 4396596; 11378091; 7979122; 11371252; 841083; 11367456; 11111282; 11492340; 7854833; 11369030; 444583; 11364800; 10400166; 11374268; 11490222; 11372964; 8150742; 3133522; 11335955; 11377192; 11488839; 7988050; 11366468; 11367362; 11369924; 11375618; 8026221; 11462166; 748365; 11375524

# OMIM_ID:
116790; 126453

# Metagene_ID:
DOPAMINE BETA-HYDROXYLASE DEFICIENCY (DßH): 445; TYROSINE HYDROXYLASE DEFICIENCY: 439; AROMATIC L-AMINO ACID DECARBOXYLASE DEFICIENCY: 354

# BiGG_ID:
42467

# Wikipedia_ID:
Dopamine

# METLIN_ID:
64

# Ref_ID:
10494443; 10489384; 16601073; 16818870; 7059264; 12649306; 16412483; 12622787; 9849813; 12834252; 16806124; 16757377; 16449954; 16317894; 7161364; 8884658; 16146016; 6085021; 15080725; 9360553

# ChEBI_ID:
18243

# CAS_Registry_Number:
62-31-7

# InChI:
InChI=1/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2

# Synthesis_Reference:
Preparation of phenethylamines from b-nitrostyrenes.     Murahashi, Shunichi; Kono, Masahiko.  (Ube Industries, Ltd., Japan).    Jpn. Kokai Tokkyo Koho  (1991),     5 pp.

# Melting_Point:
128 oC

# Melting_Point_predicted:
97.7 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
535 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
1000.0 mg/mL [MEYLAN,WM et al. (1996)]; 7.43 mg/mL [Predicted by ALOGPS]

# phys_charge:
1

# State:
Solid

# LogP:
-0.98 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-0.39 [Predicted by ALOGPS]; 0.548 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Dopamine.pdf:::1132562197114650328

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Dopamine.mol:::1132723805234461317

# SDF_File_[Text]:
tbl_chemical:::HMDB00073.sdf:::119283174245293700

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00073.pdb:::119283174418272624

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::050105_P00_01_IS_1DP_noesy.png:::116890067175047353274

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::050105_P00_01_IS_1DP_Presat.zip:::115505510830237979

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::050105_P00_01_IS_1DP_Assigned.png:::11563703618649699

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050105_P00_01_IS_2DHSQC_24.jpg:::114781247259187771

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050105_P00_01_IS_2DHSQC_24.zip:::114781247259984390

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050105_P00_01_IS_2DHSQC_24_Assigned.jpg:::116241728879836071

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Dopamine.gif:::1132732105609483442

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00073_peaks.txt:::1156309528678812914

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Dopamine_C.gif:::1132737675633991443

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00073_peaks.txt:::1156310719028522955

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00073L.png:::117555262034195190; Medium Energy:tbl_ms:::HMDB00073M.png:::117555267116719846; High Energy:tbl_ms:::HMDB00073H.png:::117555270993978992

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; Extracellular

# Tissue_Location:
Adipose Tissue; Adrenal Cortex; Adrenal Gland; Adrenal Medulla; Bladder; Brain; Epidermis; Fibroblasts; Kidney; Kidney (Adrenal Glands); Muscle; Myelin; Nerves; Neuron; Neurons; Pancreas; Placenta; Platelet; Skeletal Muscle; Spleen; Striatum; Testes

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	0.107 (0.043-0.172)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	15080725
Urine	0.22 +/- 0.07	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	12622787
Urine	0.44 +/- 0.13	umol/mmol_creatinine	Adolescent:13-18_yrs_old	Both	Normal	12622787
Blood	0.00022 +/- 0.00020	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	0.0001	umol/L	Adult:>18_yrs_old	Both	Normal	12649306
Cerebrospinal_Fluid(CSF)	0.002+/-0.002	umol/L	Adult:>18_yrs_old	Both	Normal	12834252
Cerebrospinal_Fluid(CSF)	0.0059 +/- 0.002	uM	Elderly:>65_yrs_old	Both	Normal	10494443
Cerebrospinal_Fluid(CSF)	0.0045 +/- 0.0026	uM	Adult:>18_yrs_old	Both	Normal	10494443


# Concentration_[Abnormal]:
Urine	0.49 +/- 0.06	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Vitiligo	12622787
Urine	0.37 +/- 0.03	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Vitiligo	12622787
Urine	0.4 +/- 0.05	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Vitiligo	12622787
Cerebrospinal_Fluid(CSF)	0.00002 +/- 0.000006 	uM	Adult:>18_yrs_old	Both	hypothyroid patients	9849813
Cerebrospinal_Fluid(CSF)	0.000021 (0.000015-0.000027)	umol/L	Adult:>18_yrs_old	Both	Hypothyroidism	9849813
Cerebrospinal_Fluid(CSF)	0.000078 (0.0000065-0.00015)	uM	Adult:>18_yrs_old	Both	Alzheimer's Disease	10494443


# Associated_Disorders:
Alzheimer's Disease; Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency; Dihydropteridine reductase deficiency : Decreased; Dopamine Beta-Hydroxylase Deficiency; hypothyroid patients; Hypothyroidism; Iron Deficiency; Parkinson's Disease; Parkinsonism; Septic Shock; Tyrosine Hydroxylase (TH) Deficiency; Vitiligo

# Pathway_Names:
Not Available

# Pathway_Images:
Not Available

# KEGG_Images:
Not Available

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5630

# Metabolic_Enzyme_1_Name:
Membrane copper amine oxidase

# Metabolic_Enzyme_1_Synonyms:
Semicarbazide-sensitive amine oxidase; SSAO; Vascular adhesion protein 1; VAP-1; HPAO

# Metabolic_Enzyme_1_Gene_Name:
AOC3

# Metabolic_Enzyme_1_Protein_Sequence:
>Membrane copper amine oxidase
MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVW
AEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHP
RGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDF
SDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSA
DSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN

# Metabolic_Enzyme_1_Number_of_Residues:
763

# Metabolic_Enzyme_1_Molecular_Weight:
84623

# Metabolic_Enzyme_1_Theoretical_pI:
6.51

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_1_Specific_Function:
Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity

# Metabolic_Enzyme_1_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_1_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_1_Signals:
1-19

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1399032

# Metabolic_Enzyme_1_SwissProt_ID:
AOC3_HUMAN (Q16853)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
AOC3

# Metabolic_Enzyme_1_Geneatlas_id:
AOC3

# Metabolic_Enzyme_1_hgnc_id:
HGNC:550

# Metabolic_Enzyme_1_PDB_ID:
1PU4

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_1_Gene_Sequence:
>2292 bp
ATGAACCAGAAGACAATCCTCGTGCTCCTCATTCTGGCCGTCATCACCATCTTTGCCTTG
GTTTGTGTCCTGCTGGTGGGCAGGGGTGGAGATGGGGGTGAACCCAGCCAGCTTCCCCAT
TGCCCCTCTGTATCTCCCAGTGCCCAGCCTTGGACACACCCTGGCCAGAGCCAGCTGTTT
GCAGACCTGAGCCGAGAGGAGCTGACGGCTGTGATGCGCTTTCTGACCCAGCGGCTGGGG
CCAGGGCTGGTGGATGCAGCCCAGGCCCGGCCCTCGGACAACTGTGTCTTCTCAGTGGAG
TTGCAGCTGCCTCCCAAGGCTGCAGCCCTGGCTCACTTGGACAGGGGGAGCCCCCCACCT
GCCCGGGAGGCACTGGCCATCGTCTTCTTTGGCAGGCAACCCCAGCCCAACGTGAGTGAG
CTGGTGGTGGGGCCACTGCCTCACCCCTCCTACATGCGGGACGTGACTGTGGAGCGTCAT
GGAGGCCCCCTGCCCTATCACCGACGCCCCGTGCTGTTCCAAGAGTACCTGGACATAGAC
CAGATGATCTTCAACAGAGAGCTGCCCCAGGCTTCTGGGCTTCTCCACCACTGTTGCTTC
TACAAGCACCGGGGACGGAACCTGGTGACAATGACCACGGCTCCCCGTGGTCTGCAATCA
GGGGACCGGGCCACCTGGTTTGGCCTCTACTACAACATCTCGGGCGCTGGGTTCTTCCTG
CACCACGTGGGCTTGGAGCTGCTAGTGAACCACAAGGCCCTTGACCCTGCCCGCTGGACT
ATCCAGAAGGTGTTCTATCAAGGCCGCTACTACGACAGCCTGGCCCAGCTGGAGGCCCAG
TTTGAGGCCGGCCTGGTGAATGTGGTGCTGATCCCAGACAATGGCACAGGTGGGTCCTGG
TCCCTGAAGTCCCCTGTGCCCCCGGGTCCAGCTCCCCCTCTACAGTTCTATCCCCAAGGC
CCCCGCTTCAGTGTCCAGGGAAGTCGAGTGGCCTCCTCACTGTGGACTTTCTCCTTTGGC
CTCGGAGCATTCAGTGGCCCAAGGATCTTTGACGTTCGCTTCCAAGGAGAAAGACTAGTT
TATGAGATAAGCCTCCAAGAGGCCTTGGCCATCTATGGTGGAAATTCCCCAGCAGCAATG
ACGACCCGCTATGTGGATGGAGGCTTTGGCATGGGCAAGTACACCACGCCCCTGACCCGT
GGGGTGGACTGCCCCTACTTGGCCACCTACGTGGACTGGCACTTCCTTTTGGAGTCCCAG
GCCCCCAAGACAATACGTGATGCCTTTTGTGTGTTTGAACAGAACCAGGGCCTCCCCCTG
CGGCGACACCACTCAGATCTCTACTCGCACTACTTTGGGGGTCTTGCGGAAACGGTGCTG
GTCGTCAGATCTATGTCCACCTTGCTCAACTATGACTATGTGTGGGATACGGTCTTCCAC
CCCAGTGGGGCCATAGAAATACGATTCTATGCCACGGGCTACATCAGCTCGGCATTCCTC
TTTGGTGCTACTGGGAAGTACGGGAACCAAGTGTCAGAGCACACCCTGGGCACGGTCCAC
ACCCACAGCGCCCACTTCAAGGTGGATCTGGATGTAGCAGGACTGGAGAACTGGGTCTGG
GCCGAGGATATGGTCTTTGTCCCCATGGCTGTGCCCTGGAGCCCTGAGCACCAGCTGCAG
AGGCTGCAGGTGACCCGGAAGCTGCTGGAGATGGAGGAGCAGGCCGCCTTCCTCGTGGGA
AGCGCCACCCCTCGCTACCTGTACCTGGCCAGCAACCACAGCAACAAGTGGGGTCACCCC
CGGGGCTACCGCATCCAGATGCTCAGCTTTGCTGGAGAGCCGCTGCCCCAAAACAGCTCC
ATGGCGAGAGGCTTCAGCTGGGAGAGGTACCAGCTGGCTGTGACCCAGCGGAAGGAGGAG
GAGCCCAGTAGCAGCAGCGTTTTCAATCAGAATGACCCTTGGGCCCCCACTGTGGATTTC
AGTGACTTCATCAACAATGAGACCATTGCTGGAAAGGATTTGGTGGCCTGGGTGACAGCT
GGTTTTCTGCATATCCCACATGCAGAGGACATTCCTAACACAGTGACTGTGGGGAACGGC
GTGGGCTTCTTCCTCCGACCCTATAACTTCTTTGACGAAGACCCCTCCTTCTACTCTGCC
GACTCCATCTACTTCCGAGGGGACCAGGATGCTGGGGCCTGCGAGGTCAACCCCCTAGCT
TGCCTGCCCCAGGCTGCTGCCTGTGCCCCCGACCTCCCTGCCTTCTCCCACGGGGGCTTC
TCTCACAACTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U39447

# Metabolic_Enzyme_1_Chromosome_Location:
Not Available

# Metabolic_Enzyme_1_Locus:
Not Available

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
8972912; 9653080

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5510

# Metabolic_Enzyme_2_Name:
Aromatic-L-amino-acid decarboxylase

# Metabolic_Enzyme_2_Synonyms:
AADC; DOPA decarboxylase; DDC

# Metabolic_Enzyme_2_Gene_Name:
DDC

# Metabolic_Enzyme_2_Protein_Sequence:
>AromaticLaminoacid decarboxylase
MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV
EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD
WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM
EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV
ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN
PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL
KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN
EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE


# Metabolic_Enzyme_2_Number_of_Residues:
480

# Metabolic_Enzyme_2_Molecular_Weight:
53895

# Metabolic_Enzyme_2_Theoretical_pI:
7.21

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
 ||
>>>
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine

# Metabolic_Enzyme_2_Pathway:
map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00901  Indole and ipecac alkaloid biosynthesis;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_2_Reaction:
L-tryptophan = tryptamine + CO2

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00282:Pyridoxal_deC

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 4.1.1.28

# Metabolic_Enzyme_2_GenBank_ID_Protein:
181521

# Metabolic_Enzyme_2_SwissProt_ID:
DDC_HUMAN (P20711)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
DDC

# Metabolic_Enzyme_2_Geneatlas_id:
DDC

# Metabolic_Enzyme_2_hgnc_id:
HGNC:2719

# Metabolic_Enzyme_2_PDB_ID:
1JS3

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>1443 bp
ATGAACGCAAGTGAATTCCGAAGGAGAGGGAAGGAGATGGTGGATTACGTGGCCAACTAC
ATGGAAGGCATTGAGGGACGCCAGGTCTACCCTGACGTGGAGCCCGGGTACCTGCGGCCG
CTGATCCCTGCCGCTGCCCCTCAGGAGCCAGACACGTTTGAGGACATCATCAACGACGTT
GAGAAGATAATCATGCCTGGGGTGACGCACTGGCACAGCCCCTACTTCTTCGCCTACTTC
CCCACTGCCAGCTCGTACCCGGCCATGCTTGCGGACATGCTGTGCGGGGCCATTGGCTGC
ATCGGCTTCTCCTGGGCGGCAAGCCCAGCATGCACAGAGCTGGAGACTGTGATGATGGAC
TGGCTCGGGAAGATGCTGGAACTACCAAAGGCATTTTTGAATGAGAAAGCTGGAGAAGGG
GGAGGAGTGATCCAGGGAAGTGCCAGTGAAGCCACCCTGGTGGCCCTGCTGGCCGCTCGG
ACCAAAGTGATCCATCGGCTGCAGGCAGCGTCCCCAGAGCTCACACAGGCCGCTATCATG
GAGAAGCTGGTGGCTTACTCATCCGATCAGGCACACTCCTCAGTGGAAAGAGCTGGGTTA
ATTGGTGGAGTGAAATTAAAAGCCATCCCCTCAGATGGCAACTTCGCCATGCGTGCGTCT
GCCCTGCAGGAAGCCCTGGAGAGAGACAAAGCGGCTGGCCTGATTCCTTTCTTTATGGTT
GCCACCCTGGGGACCACAACATGCTGCTCCTTTGACAATCTCTTAGAAGTCGGTCCTATC
TGCAACAAGGAAGACATATGGCTGCACGTTGATGCAGCCTACGCAGGCAGTGCATTCATC
TGCCCTGAGTTCCGGCACCTTCTGAATGGAGTGGAGTTTGCAGATTCATTCAACTTTAAT
CCCCACAAATGGCTATTGGTGAATTTTGACTGTTCTGCCATGTGGGTGAAAAAGAGAACA
GACTTAACGGGAGCCTTTAGACTGGACCCCACTTACCTGAAGCACAGCCATCAGGATTCA
GGGCTTATCACTGACTACCGGCATTGGCAGATACCACTGGGCAGAAGATTTCGCTCTTTG
AAAATGTGGTTTGTATTTAGGATGTATGGAGTCAAAGGACTGCAGGCTTATATCCGCAAG
CATGTCCAGCTGTCCCATGAGTTTGAGTCACTGGTGCGCCAGGATCCCCGCTTTGAAATC
TGTGTGGAAGTCATTCTGGGGCTTGTCTGCTTTCGGCTAAAGGGTTCCAACAAAGTGAAT
GAAGCTCTTCTGCAAAGAATAAACAGTGCCAAAAAAATCCACTTGGTTCCATGTCACCTC
AGGGACAAGTTTGTCCTGCGCTTTGCCATCTGTTCTCGCACGGTGGAATCTGCCCATGTG
CAGCGGGCCTGGGAACACATCAAAGAGCTGGCGGCCGACGTGCTGCGAGCAGAGAGGGAG
TAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M76180

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_2_Locus:
7p11

# Metabolic_Enzyme_2_SNPs:
rs6263; rs6262; rs11575542; rs11575292; rs6264; rs11575302; rs11575290; rs921451; rs2329342; rs2329371; rs10499694; rs1451374; rs10276473; rs6949897; rs4452748; rs921450; rs7803440; rs7803788; rs1470747; rs1451375; rs6969081; rs1966839; rs7803903; rs10249420; rs1451373; rs10265930; rs10499695; rs7786398; rs11575548; rs11974297; rs10250513; rs11575551; rs1349491; rs11575549; rs2060762; rs11575288; rs2329341; rs2329343; rs11575286; rs11575550; rs6593002; rs3779074; rs2242041; rs3837091; rs2329340; rs11765748; rs3779075; rs2044859; rs10499696; rs7779110; rs2876830; rs2242042; rs3779076; rs4947644; rs11765109; rs930707; rs11575282; rs11575273; rs17133881; rs4585697; rs11575544; rs17133878; rs10255505; rs11575281; rs6956737; rs11575543; rs11575545; rs2060761; rs11575553; rs6962356; rs11575546; rs10229387; rs11575552; rs11575284; rs11575280; rs6972476; rs11575547; rs6975312; rs998850; rs730092; rs896309; rs880028; rs1376524; rs745043; rs6592962; rs10899734; rs7790758; rs3887825; rs3735274; rs6965432; rs4948196; rs11761683; rs11238134; rs10899735; rs1451371; rs3807556; rs4947580; rs6951323; rs6950777; rs4580999; rs9942686; rs10277662; rs4947584; rs2198144; rs6592961; rs3779078; rs11983581; rs1037351; rs4436083; rs1901312; rs3807552; rs11983757; rs1451372; rs2167364; rs11772714; rs4947577; rs11575457; rs11768267; rs11575334; rs3735273; rs7809758; rs11575320; rs11980368; rs4377912; rs6957607; rs4947582; rs7776816; rs11981575; rs11575464; rs4948201; rs6967361; rs1451370; rs11575536; rs6944090; rs17133853; rs2876827; rs11575340; rs10244632; rs11575489; rs6592952; rs6952023; rs10228056; rs896308; rs11974997; rs11575518; rs4602840; rs11575378; rs11575527; rs11575375; rs12718541; rs11575387; rs745042; rs1817074; rs4579483; rs7791875; rs2122822; rs11575399; rs11575511; rs4947535; rs11575351; rs1376523; rs4992502; rs6947293; rs11575435; rs11575407; rs11575338; rs11575516; rs11763837; rs11575400; rs17133842; rs11575520; rs7777600; rs4397355; rs1901311; rs10274275; rs11575451; rs11575538; rs4948197; rs11575388; rs4947634; rs12667533; rs10268819; rs11575441; rs11575506; rs3779084; rs6974583; rs17133877; rs12718527; rs3807566; rs6979229; rs11238138; rs10499693; rs11982708; rs1982406; rs2329367; rs2100280; rs11238133; rs3807555; rs11575461; rs2876829; rs7803247; rs10899736; rs6951648; rs1007702; rs11575500; rs11771818; rs11575444; rs11575541; rs4329234; rs11575442; rs10239830; rs9918702; rs11575501; rs1007749; rs11575494; rs4947576; rs11575523; rs7780360; rs6963534; rs11982772; rs11575309; rs4947581; rs11575462; rs1349492; rs732215; rs11575322; rs2329365; rs10271341; rs4989851; rs3807558; rs11575298; rs4433100; rs11575537; rs731689; rs4490786; rs4245549; rs896307; rs17634958; rs3757472; rs4470989; rs11238131; rs11575535; rs11982776; rs7808025; rs3807562; rs11575404; rs2122817; rs11575522; rs6592963; rs5884156; rs3807553; rs10249982; rs11575510; rs1470750; rs4947631; rs11575463; rs12718572; rs12535024; rs2329366; rs11575383; rs6955487; rs2122821; rs17665398; rs11765543; rs7809477; rs12538938; rs11575327; rs11575521; rs1451369; rs12112308; rs11575360; rs17553495; rs11575454; rs1817073; rs11575447; rs2167367; rs3823674; rs11575450; rs11575507; rs11575319; rs11575301; rs17152014; rs10239937; rs6970468; rs11575295; rs7785224; rs4947621; rs17733244; rs3470; rs4449741; rs11575532; rs11575460; rs2167366; rs17634717; rs3779083; rs11575423; rs11575504; rs880029; rs17553791; rs6952381; rs11575502; rs9918591; rs11575406; rs11771860; rs11575519; rs1451368; rs2122818; rs11575372; rs11575343; rs11575300; rs11575368; rs11575381; rs13222408; rs11575509; rs12718574; rs11575455; rs11575540; rs11768997; rs7797142; rs17635123; rs7792578; rs11575515; rs11575526; rs11575491; rs11767384; rs6953675; rs7807564; rs11575385; rs2329364; rs11575332; rs11575512; rs11575296; rs12665948; rs11575428; rs11575305; rs11575323; rs11575503; rs11575339; rs11575449; rs6964142; rs2122819; rs11575304; rs2876826; rs11575342; rs11767334; rs11575456; rs17152020; rs11575472; rs4948225; rs11575313; rs3807563; rs7792474; rs11575525; rs11978797; rs10267323; rs2329368; rs11575424; rs2100279; rs11575434; rs6963996; rs11575513; rs11575534; rs11763051; rs11575411; rs11575392; rs11575425; rs11575505; rs11575328; rs17665588; rs11575431; rs4947625; rs6592969; rs11575349; rs11575353; rs2060763; rs12718528; rs11575293; rs11575492; rs6944912; rs11575356; rs2329369; rs11575429; rs11575438; rs7802199; rs3887826; rs11575453; rs11575414; rs11575321; rs2876828; rs12535064; rs7812167; rs6592973; rs11575508; rs1807066; rs1304691; rs11575437; rs11575514; rs17634771; rs1466163; rs11575374; rs7809234; rs3779082; rs11575430; rs12671474; rs11575422; rs7810677; rs3071970; rs11575446; rs11575410; rs11575325; rs2167363; rs17665670; rs13311361; rs11575352; rs11575483; rs11575413; rs7778349; rs6975453; rs11575359; rs12718529; rs1451366; rs11575531; rs11575493; rs1597639; rs11575528; rs4948010; rs4947510; rs3829897; rs11575575; rs6593010; rs11575557; rs4947511; rs11575565; rs11575568; rs11575564; rs11575574; rs11575266; rs10278338; rs11575562; rs11575259; rs11575264; rs11575561; rs11575570; rs11575271; rs11575566; rs11575569; rs11575267; rs11575556; rs11575268; rs11575376; rs11575377; rs11575291; rs12670911; rs10233346; rs11575274; rs28607134; rs28799122; rs34618339; rs13223166; rs11302809; rs4515495; rs10281167; rs34752519; rs2242040; rs13223157; rs13233973; rs13245496; rs2242039; rs5884158; rs13237075; rs2329370; rs28510954; rs10600316; rs10229102; rs13226079; rs3071145; rs11366731; rs10601831; rs35197006; rs7791943; rs2242038; rs5014165; rs13226287; rs7782081; rs12718674; rs11575276; rs2167368; rs10255145; rs11575277; rs34606153; rs6975015; rs11410259; rs10229369; rs10247443; rs11575275; rs10609620; rs7787209; rs13245018; rs34348593; rs1988550; rs35330002; rs35591152; rs11450560; rs11575468; rs34658291; rs11575395; rs35299591; rs34021747; rs35586188; rs11575432; rs34314851; rs35089176; rs35997922; rs12537169; rs12718558; rs11575294; rs1470749; rs11315611; rs11575315; rs13228083; rs35582115; rs4947588; rs13308328; rs3779077; rs3807554; rs5884157; rs7811992; rs12718563; rs36110443; rs11575482; rs11330628; rs1107742; rs731690; rs11575433; rs4948216; rs11575311; rs11575326; rs6965025; rs11575347; rs11575474; rs11575316; rs11575459; rs35993062; rs3840579; rs11575314; rs11575465; rs5884154; rs3779080; rs34950596; rs2198143; rs10718396; rs10587155; rs36090705; rs34869137; rs11575533; rs3071964; rs13234331; rs34002033; rs1137337; rs34977933; rs3779081; rs35173748; rs1470748; rs12538830; rs4947594; rs11575497; rs35008528; rs4947589; rs2084723; rs11575306; rs34971815; rs34780941; rs13222708; rs11575346; rs1107743; rs6953661; rs12718583; rs11575329; rs6959596; rs36104801; rs7794360; rs11763809; rs13244875; rs11575362; rs11575415; rs28889020; rs35666388; rs35765995; rs6968322; rs11575389; rs11761208; rs33974864; rs6975747; rs13232900; rs34329145; rs11575369; rs7810684; rs11978769; rs4143196; rs28706313; rs3071975; rs7781950; rs28534613; rs12718611; rs4377913; rs1580031; rs5884155; rs28531762; rs34984600; rs11309882; rs11575318; rs35539624; rs11575333; rs36063027; rs11980236; rs7785984; rs35432113; rs34298125; rs11575363; rs7455902; rs7786752; rs10258321; rs34582666; rs11575397; rs11575530; rs4455783; rs11575529; rs11575312; rs33945116; rs4948205; rs1304693; rs11575401; rs35915381; rs2122820; rs34487683; rs11763807; rs13225182; rs6960966; rs34791889; rs36005269; rs11575303; rs6952938; rs6964313; rs10710723; rs11575417; rs1901313; rs11378977; rs11575524; rs11575394; rs13229021; rs11575308; rs11575348; rs12666643; rs11575499; rs35269833; rs11575393; rs11575330; rs4052336; rs3071963; rs11575458; rs11575367; rs13228086; rs35484306; rs7793185; rs11575390; rs12537186; rs35092758; rs3807557; rs11575555; rs11575554; rs11575269; rs11575567; rs11575257; rs11575559; rs11575265; rs11575261; rs11575571; rs11575270; rs11575572; rs35937247; rs11575260; rs4947662; rs13243080; rs11575563; rs35517528; rs10499697; rs11238214; rs11489734; rs11977135; rs12666409; rs13228274; rs3911193; rs4947396; rs6593011; rs7790230; rs7804365; rs7807335; rs978784

# Metabolic_Enzyme_2_General_References:
2590185; 1612608; 1540578; 8510497; 1395716; 10391209

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5393

# Metabolic_Enzyme_3_Name:
Amine oxidase [flavin-containing] B

# Metabolic_Enzyme_3_Synonyms:
Monoamine oxidase type B; MAO-B

# Metabolic_Enzyme_3_Gene_Name:
MAOB

# Metabolic_Enzyme_3_Protein_Sequence:
>Amine oxidase flavincontaining 
BMSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGS
YVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFW
RTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHE
VSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYID
QTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIV
YYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEE
RLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVD
RIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITT
TFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV

# Metabolic_Enzyme_3_Number_of_Residues:
520

# Metabolic_Enzyme_3_Molecular_Weight:
58764

# Metabolic_Enzyme_3_Theoretical_pI:
7.55

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine

# Metabolic_Enzyme_3_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_3_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01593:Amino_oxidase

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
490-516

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.4.3.4

# Metabolic_Enzyme_3_GenBank_ID_Protein:
398415

# Metabolic_Enzyme_3_SwissProt_ID:
AOFB_HUMAN (P27338)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
MAOB

# Metabolic_Enzyme_3_Geneatlas_id:
MAOB

# Metabolic_Enzyme_3_hgnc_id:
HGNC:6834

# Metabolic_Enzyme_3_PDB_ID:
2BK3

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type IV membrane protein; cytoplasmic side

# Metabolic_Enzyme_3_Gene_Sequence:
>1560 bp
ATGAGCAACAAATGCGACGTGGTCGTGGTGGGGGGCGGCATCTCAGGTATGGCAGCAGCC
AAACTTCTGCATGACTCTGGACTGAATGTGGTTGTTCTGGAAGCCCGGGACCGTGTGGGA
GGCAGGACTTACACTCTTAGGAACCAAAAGGTTAAATATGTGGACCTTGGAGGATCCTAT
GTTGGACCAACCCAGAATCGTATCTTGAGATTAGCCAAGGAGCTAGGATTGGAGACCTAC
AAAGTGAATGAGGTTGAGCGTCTGATCCACCATGTAAAGGGCAAATCATACCCCTTCAGG
GGGCCATTCCCACCTGTATGGAATCCAATTACCTACTTAGATCATAACAACTTTTGGAGG
ACAATGGATGACATGGGGCGAGAGATTCCGAGTGATGCCCCATGGAAGGCTCCCCTTGCA
GAAGAGTGGGACAACATGACAATGAAGGAGCTACTGGACAAGCTCTGCTGGACTGAATCT
GCAAAGCAGCTTGCCACTCTCTTTGTGAACCTGTGTGTCACTGCAGAGACCCATGAGGTC
TCTGCTCTCTGGTTCCTGTGGTATGTGAAGCAGTGTGGAGGCACAACAAGAATCATCTCG
ACAACAAATGGAGGACAGGAGAGGAAATTTGTGGGCGGATCTGGTCAAGTGAGTGAGCGG
ATAATGGACCTCCTTGGAGACCGAGTGAAGCTGGAGAGGCCTGTGATCTACATTGACCAG
ACAAGAGAAAATGTCCTTGTGGAGACCCTAAACCATGAGATGTATGAGGCTAAATATGTG
ATTAGTGCTATTCCTCCTACTCTGGGCATGAAGATTCACTTCAATCCCCCTCTGCCAATG
ATGAGAAACCAGATGATCACTCGTGTGCCTTTGGGTTCAGTCATCAAGTGTATAGTTTAT
TATAAAGAGCCTTTCTGGAGGAAAAAGGATTACTGTGGAACCATGATTATTGATGGAGAA
GAAGCTCCAGTTGCCTACACGTTGGATGATACCAAACCTGAAGGCAACTATGCTGCCATA
ATGGGATTTATCCTGGCCCACAAAGCCAGAAAACTGGCACGTCTTACCAAAGAGGAAAGG
TTGAAGAAACTTTGTGAACTCTATGCCAAGGTTCTGGGTTCCCTAGAAGCTCTGGAGCCA
GTGCATTATGAAGAAAAGAACTGGTGTGAGGAGCAGTACTCTGGGGGCTGCTACACAACT
TATTTCCCCCCTGGGATCCTGACTCAATATGGAAGGGTTCTACGCCAGCCAGTGGACAGG
ATTTACTTTGCAGGCACCGAGACTGCCACACACTGGAGCGGCTACATGGAGGGGGCTGTA
GAGGCCGGGGAGAGAGCAGCCCGAGAGATCCTGCATGCCATGGGGAAGATTCCAGAGGAT
GAAATCTGGCAGTCAGAACCAGAGTCTGTGGATGTCCCTGCACAGCCCATCACCACCACC
TTTTTGGAGAGACATTTGCCCTCCGTGCCAGGCCTGCTCAGGCTGATTGGATTGACCACC
ATCTTTTCAGCAACGGCTCTTGGCTTCCTGGCCCACAAAAGGGGGCTACTTGTGAGAGTC


# Metabolic_Enzyme_3_GenBank_ID_Gene:
S62734

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_3_Locus:
Xp11.23

# Metabolic_Enzyme_3_SNPs:
rs7879356; rs6324; rs12010260; rs2072745; rs17462; rs3027440; rs7066677; rs3027439; rs1799836; rs3027453; rs2311013; rs3027441; rs5905512; rs3027459; rs2239450; rs2239441; rs7890174; rs5952297; rs3027444; rs5952330; rs7883073; rs5952671; rs6520902; rs2239449; rs6651806; rs3027454; rs7057075; rs12394221; rs2238969; rs12008119; rs7888450; rs12388038; rs2283727; rs12013965; rs17310637; rs12008438; rs5952294; rs5952340; rs12008548; rs12014398; rs1014876; rs3027449; rs2283730; rs2283729; rs5952813; rs6520901; rs5952352; rs2205655; rs10521432; rs6610856; rs12006628; rs3027450; rs6610853; rs2283731; rs3027456; rs2283728; rs9887326; rs5952325; rs3027442; rs7879586; rs12389168; rs3817729; rs12851487; rs5952686; rs3736672; rs2056913; rs1569424; rs7053203; rs2092042; rs7876594; rs12010996; rs3027457; rs9887047; rs3027451; rs17146716; rs7061798; rs3027464; rs6609259; rs3027446; rs736944; rs2239442; rs6609260; rs7067187; rs3027466; rs12558324; rs7888462; rs3027452; rs2092040; rs4824562; rs17146721; rs7884044; rs3027461; rs12389234; rs12007768; rs17244906; rs5952795; rs17146719; rs5905449; rs5952799; rs12394863; rs3027458; rs3027443; rs9698576; rs2092041; rs7892217; rs7061088; rs12689868; rs7067027; rs3027448; rs12558614; rs7057957; rs1040398; rs1040400; rs3027435; rs1181252; rs1040399; rs3027434; rs17852046; rs12850496; rs12845773; rs17856663; rs12845783; rs5952696; rs3191382; rs1181251; rs35285191; rs1051000; rs1803940; rs3027438; rs1051003; rs1050990; rs4339787; rs28530533; rs3027468; rs5952754; rs5952690; rs12558961; rs12852985; rs34468176; rs2311012; rs5905428; rs34165496; rs34825602; rs7892394; rs5952812; rs11091124; rs5906017; rs28522648; rs5952677; rs11282093; rs5906045; rs3838196; rs3027455; rs28667959; rs3027463; rs35676271; rs12841775; rs35574902; rs3027447; rs28657720; rs6610848; rs28531879; rs4824563; rs6610854; rs7060566; rs12396954; rs3027469; rs35687186; rs5952736; rs35375952; rs7057164; rs34716997; rs7062993; rs7063171; rs11412800; rs6651629; rs12845848; rs12853563; rs12012179; rs28368734; rs12115950; rs35968321; rs3027460; rs12394356; rs35439218; rs36085366; rs34265248; rs35762562; rs2239451; rs34292051; rs3027445; rs11320541; rs10481834; rs12845568; rs4592179; rs3216388; rs34945383; rs34220802; rs6610855; rs34261731; rs28485908; rs7888867; rs11431011; rs4071606; rs12390352; rs10567219; rs35520175; rs28527225; rs36068670; rs5952687; rs7888857; rs5952777; rs34822523; rs12010683; rs7883563; rs5952814; rs36209687; rs5952751; rs2238970; rs5952744; rs35797631; rs12389578; rs7474005; rs3027465; rs5952768; rs5906031; rs28636832; rs34252524; rs7058426; rs12391346; rs12689072; rs35943983; rs12395246; rs11414517; rs3027467; rs12013925; rs3736671; rs28421767; rs7058949; rs35634965; rs28754429; rs1894610; rs36102775; rs9887081; rs5952817; rs12855578; rs10658111; rs7062575; rs4620438; rs28568938; rs35291347; rs11797733; rs35054600; rs5952335; rs3027462; rs5952712; rs34752122; rs3054011; rs3027437; rs28577261; rs3027433; rs3761584; rs3027436; rs3027432; rs12558036; rs3027418; rs3027419; rs3027420; rs3027421; rs3027423; rs3027424; rs3027425; rs3027426; rs3027427; rs3027428; rs3027429; rs3027430; rs3027431; rs4351544; rs7884135; rs7890899

# Metabolic_Enzyme_3_General_References:
2023912; 3387449; 8515265; 1432104; 11049757; 11753429

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5504

# Metabolic_Enzyme_4_Name:
Catechol O-methyltransferase

# Metabolic_Enzyme_4_Synonyms:
Not Available

# Metabolic_Enzyme_4_Gene_Name:
COMT

# Metabolic_Enzyme_4_Protein_Sequence:
>Catechol Omethyltransferase
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRIL
NHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCG
YSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKY
DVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFE
CTHYQSFLEYREVVDGLEKAIYKGPGSEAGP

# Metabolic_Enzyme_4_Number_of_Residues:
271

# Metabolic_Enzyme_4_Molecular_Weight:
30037

# Metabolic_Enzyme_4_Theoretical_pI:
5.15

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  O-methyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol

# Metabolic_Enzyme_4_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_4_Reaction:
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01596:Methyltransf_3

# Metabolic_Enzyme_4_Signals:
1-32

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.1.1.6

# Metabolic_Enzyme_4_GenBank_ID_Protein:
180920

# Metabolic_Enzyme_4_SwissProt_ID:
COMT_HUMAN (P21964)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
COMT

# Metabolic_Enzyme_4_Geneatlas_id:
COMT

# Metabolic_Enzyme_4_hgnc_id:
HGNC:2228

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Isoform S-COMT:Cytoplasm. Isoform MB-COMT:Cell membrane; single-pass type II membrane protein; extracellular side

# Metabolic_Enzyme_4_Gene_Sequence:
>816 bp
ATGCCGGAGGCCCCGCCTCTGCTGTTGGCAGCTGTGTTGCTGGGCCTGGTGCTGCTGGTG
GTGCTGCTGCTGCTTCTGAGGCACTGGGGCTGGGGCCTGTGCCTTATCGGCTGGAACGAG
TTCATCCTGCAGCCCATCCACAACCTGCTCATGGGTGACACCAAGGAGCAGCGCATCCTG
AACCACGTGCTGCAGCATGCGGAGCCCGGGAACGCACAGAGCGTGCTGGAGGCCATTGAC
ACCTACTGCGAGCAGAAGGAGTGGGCCATGAACGTGGGCGACAAGAAAGGCAAGATCGTG
GACGCCGTGATTCAGGAGCACCAGCCCTCCGTGCTGCTGGAGCTGGGGGCCTACTGTGGC
TACTCAGCTGTGCGCATGGCCCGCCTGCTGTCACCAGGGGCGAGGCTCATCACCATCGAG
ATCAACCCCGACTGTGCCGCCATCACCCAGCGGATGGTGGATTTCGCTGGCGTGAAGGAC
AAGGTCACCCTTGTGGTTGGAGCGTCCCAGGACATCATCCCCCAGCTGAAGAAGAAGTAT
GATGTGGACACACTGGACATGGTCTTCCTCGACCACTGGAAGGACCGGTACCTGCCGGAC
ACGCTTCTCTTGGAGGAATGTGGCCTGCTGCGGAAGGGGACAGTGCTACTGGCTGACAAC
GTGATCTGCCCAGGTGCGCCAGACTTCCTAGCACACGTGCGCGGGAGCAGCTGCTTTGAG
TGCACACACTACCAATCGTTCCTGGAATACAGGGAGGTGGTGGACGGCCTGGAGAAGGCC
ATCTACAAGGGCCCAGGCAGCGAAGCAGGGCCCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M65212

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_4_Locus:
22q11.21-q11.23|22q11.21

# Metabolic_Enzyme_4_SNPs:
rs5031015; rs6267; rs4680; rs13306279; rs13306281; rs6270; rs740602; rs8192488; rs4818; rs769223; rs769224; rs165631; rs4633; rs6269; rs739368; rs165656; rs4646312; rs5992501; rs7287550; rs165722; rs5746849; rs11569715; rs740603; rs9332380; rs7290221; rs174674; rs9332351; rs3810595; rs174675; rs5993887; rs9332361; rs6518593; rs174680; rs9332356; rs5993882; rs11569716; rs3087869; rs9332325; rs174673; rs174678; rs5993883; rs933271; rs9332359; rs165767; rs9332347; rs8185002; rs5993879; rs9332363; rs174691; rs9332332; rs5992500; rs174682; rs9332346; rs13306280; rs362204; rs174688; rs9332342; rs11569717; rs174695; rs5993881; rs7291003; rs1544325; rs9332331; rs3819621; rs174684; rs34798238; rs174677; rs174690; rs9606196; rs174693; rs11912353; rs12053782; rs11913025; rs36111598; rs5993888; rs9332362; rs174685; rs34438295; rs5992499; rs34691071; rs9332357; rs174692; rs9332334; rs3838146; rs9332333; rs9332352; rs35014456; rs35527466; rs35558779; rs11704299; rs9332350; rs6268; rs34450201; rs9680656; rs1055503; rs11912354; rs11089323; rs5993884; rs16982842; rs174679; rs9332353; rs34300220; rs9332358; rs9332360; rs34937293; rs34966851; rs174676; rs16982844; rs5844402; rs9332323; rs35919169; rs174683; rs35777291; rs9332348; rs8140865; rs34686565; rs165737; rs4646315; rs2239393; rs165774; rs9306235; rs740601; rs5993889; rs9306234; rs4646316; rs8140835; rs4646317; rs9332370; rs174697; rs174696; rs9332377; rs4646318; rs1109436; rs9332368; rs3218737; rs34068292; rs9332369; rs9332364; rs9332372; rs9332367; rs9332365; rs4646313; rs34446512; rs34819182; rs174699; rs34234839; rs165895; rs165599; rs9332381; rs35478083; rs36082074; rs11544670; rs4986871; rs11544669; rs165879; rs35791904; rs35788262; rs13054814; rs5992498; rs5748490; rs361698; rs28600912; rs9605040; rs11703339; rs9332319; rs174689; rs9606193; rs5844403; rs9332340; rs34778315; rs11703340; rs5993886; rs14968; rs9332344; rs28621910; rs3081743; rs174681; rs361549; rs35280052; rs361708; rs12167365; rs2004497; rs12170804; rs35357972; rs9332321; rs361574; rs9332328; rs35920235; rs9332337; rs5993880; rs12814; rs9332343; rs11544667; rs9606195; rs9332349; rs11296030; rs5748492; rs9332354; rs34029447; rs35188675; rs3819619; rs8136901; rs35094299; rs9332322; rs28804429; rs174687; rs9332339; rs11912495; rs35617967; rs9332327; rs9332336; rs3841769; rs12167215; rs362253; rs9332338; rs35689277; rs11703069; rs174686; rs12168881; rs9606194; rs361699; rs9332355; rs3081741; rs5746850; rs9617852; rs28565095; rs13306277; rs174698; rs9332373; rs9332374; rs9332366; rs13054356; rs35819339; rs11460758; rs4646314; rs34016976; rs2904564; rs12158230; rs13055002; rs9332375; rs28562050; rs9332378; rs9332371; rs9332376; rs10427781; rs10427983; rs10483103; rs1110477; rs1110478; rs1110479; rs12165997; rs12169508; rs12627876; rs165655; rs165728; rs165815; rs165824; rs165840; rs165849; rs1800749; rs2020917; rs2073749; rs2239394; rs2239395; rs2240713; rs2240714; rs2240715; rs2240718; rs2518823; rs2518824; rs2871047; rs34134422; rs35219372; rs3788319; rs3788320; rs4646310; rs5746846; rs5746847; rs5748483; rs5748484; rs5993890; rs5993891; rs7288060; rs737864; rs737865; rs737866; rs758373; rs8140265; rs887199; rs887200; rs9265; rs9332314; rs9332315; rs9605030; rs9605031; rs9606186; rs9606189; rs9606201; rs9618716

# Metabolic_Enzyme_4_General_References:
1707278; 1847521; 8055944; 1993083; 1765063; 8807664; 10391209

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5319

# Metabolic_Enzyme_5_Name:
Tyrosinase precursor

# Metabolic_Enzyme_5_Synonyms:
Monophenol monooxygenase; Tumor rejection antigen AB; SK29-AB; LB24-AB

# Metabolic_Enzyme_5_Gene_Name:
TYR

# Metabolic_Enzyme_5_Protein_Sequence:
>Tyrosinase precursor
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILL
SNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVR
RNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMH
YYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRD
AEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRN
PGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQS
SMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGH
NRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLG
AAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL

# Metabolic_Enzyme_5_Number_of_Residues:
529

# Metabolic_Enzyme_5_Molecular_Weight:
60394

# Metabolic_Enzyme_5_Theoretical_pI:
6.05

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone

# Metabolic_Enzyme_5_Pathway:
map00350  Tyrosine metabolism;
 map00740  Riboflavin metabolism;
 map00940  Stilbene, coumarine and lignin biosynthesis;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_5_Reaction:
L-tyrosine + L-dopa + O2 = L-dopa + dopaquinone + H2O

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00264:Tyrosinase

# Metabolic_Enzyme_5_Signals:
1-18

# Metabolic_Enzyme_5_Transmembrane_Regions:
477-497

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.14.18.1

# Metabolic_Enzyme_5_GenBank_ID_Protein:
340037

# Metabolic_Enzyme_5_SwissProt_ID:
TYRO_HUMAN (P14679)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
TYR

# Metabolic_Enzyme_5_Geneatlas_id:
TYR

# Metabolic_Enzyme_5_hgnc_id:
HGNC:12442

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Melanosome; melanosomal membrane; single- pass type I membrane protein

# Metabolic_Enzyme_5_Gene_Sequence:
>1590 bp
ATGCTCCTGGCTGTTTTGTACTGCCTGCTGTGGAGTTTCCAGACCTCCGCTGGCCATTTC
CCTAGAGCCTGTGTCTCCTCTAAGAACCTGATGGAGAAGGAATGCTGTCCACCGTGGAGC
GGGGACAGGAGTCCCTGTGGCCAGCTTTCAGGCAGAGGTTCCTGTCAGAATATCCTTCTG
TCCAATGCACCACTTGGGCCTCAATTTCCCTTCACAGGGGTGGATGACCGGGAGTCGTGG
CCTTCCGTCTTTTATAATAGGACCTGCCAGTGCTCTGGCAACTTCATGGGATTCAACTGT
GGAAACTGCAAGTTTGGCTTTTGGGGACCAAACTGCACAGAGAGACGACTCTTGGTGAGA
AGAAACATCTTCGATTTGAGTGCCCCAGAGAAGGACAAATTTTTTGCCTACCTCACTTTA
GCAAAGCATACCATCAGCTCAGACTATGTCATCCCCATAGGGACCTATGGCCAAATGAAA
AATGGATCAACACCCATGTTTAACGACATCAATATTTATGACCTCTTTGTCTGGATGCAT
TATTATGTGTCAATGGATGCACTGCTTGGGGGATCTGAAATCTGGAGAGACATTGATTTT
GCCCATGAAGCACCAGCTTTTCTGCCTTGGCATAGACTCTTCTTGTTGCGGTGGGAACAA
GAAATCCAGAAGCTGACAGGAGATGAAAACTTCACTATTCCATATTGGGACTGGCGGGAT
GCAGAAAAGTGTGACATTTGCACAGATGAGTACATGGGAGGTCAGCACCCCACAAATCCT
AACTTACTCAGCCCAGCATCATTCTTCTCCTCTTGGCAGATTGTCTGTAGCCGATTGGAG
GAGTACAACAGCCATCAGTCTTTATGCAATGGAACGCCCGAGGGACCTTTACGGCGTAAT
CCTGGAAACCATGACAAATCCAGAACCCCAAGGCTCCCCTCTTCAGCTGATGTAGAATTT
TGCCTGAGTTTGACCCAATATGAATCTGGTTCCATGGATAAAGCTGCCAATTTCAGCTTT
AGAAATACACTGGAAGGATTTGCTAGTCCACTTACTGGGATAGCGGATGCCTCTCAAAGC
AGCATGCACAATGCCTTGCACATCTATATGAATGGAACAATGTCCCAGGTACAGGGATCT
GCCAACGATCCTATCTTCCTTCTTCACCATGCATTTGTTGACAGTATTTTTGAGCAGTGG
CTCCGAAGGCACCGTCCTCTTCAAGAAGTTTATCCAGAAGCCAATGCACCCATTGGACAT
AACCGGGAATCCTACATGGTTCCTTTTATACCACTGTACAGAAATGGTGATTTCTTTATT
TCATCCAAAGATCTGGGCTATGACTATAGCTATCTACAAGATTCAGACCCAGACTCTTTT
CAAGACTACATTAAGTCCTATTTGGAACAAGCGAGTCGGATCTGGTCATGGCTCCTTGGG
GCGGCGATGGTAGGGGCCGTCCTCACTGCCCTGCTGGCAGGGCTTGTGAGCTTGCTGTGT
CGTCACAAGAGAAAGCAGCTTCCTGAAGAAAAGCAGCCACTCCTCATGGAGAAAGAGGAT
TACCACAGCTTGTATCAGAGCCATTTATAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M27160

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_5_Locus:
11q14-q21

# Metabolic_Enzyme_5_SNPs:
rs33955261; rs1042602; rs1126809; rs1042608; rs4987234; rs3913543; rs3913544; rs1502267; rs3913542; rs1827430; rs1432447; rs12799137; rs2186640; rs12273884; rs6483004; rs11018524; rs12803764; rs621313; rs7358418; rs7117973; rs7929991; rs11018541; rs6483000; rs11820797; rs10765196; rs11824837; rs4753215; rs11018528; rs12420237; rs1393350; rs12804012; rs4399330; rs7108676; rs6483008; rs6483001; rs12419949; rs1939258; rs7940773; rs7945829; rs6483006; rs591260; rs574028; rs7929015; rs12419351; rs12808785; rs6483002; rs4396293; rs501301; rs3900053; rs11018530; rs7115192; rs6483007; rs7123654; rs7940760; rs10765197; rs9919559; rs3793974; rs16913104; rs1847142; rs7943909; rs16913107; rs7107143; rs17793750; rs7111110; rs12418383; rs1939253; rs4121403; rs7947262; rs2000554; rs12420674; rs12416719; rs1847134; rs12419364; rs7115568; rs11018525; rs12418646; rs7941532; rs11820635; rs7105390; rs12419262; rs16912259; rs6483003; rs2866556; rs12808381; rs7123206; rs3793976; rs10765200; rs10830241; rs12791412; rs12786274; rs16913039; rs2000553; rs7112373; rs7927996; rs7941110; rs12417182; rs12420662; rs11823675; rs10830250; rs7941686; rs12420278; rs4121401; rs7117190; rs12421397; rs4418813; rs12807810; rs12789914; rs10765198; rs10741305; rs12808354; rs12421155; rs12417077; rs12418148; rs11824443; rs10765201; rs2002720; rs1942493; rs12098971; rs12806466; rs7101897; rs1939255; rs2298458; rs17174064; rs7924589; rs11018544; rs10501700; rs12421402; rs12417632; rs3793975; rs7117826; rs10830253; rs17191474; rs12419341; rs12420348; rs594647; rs7129973; rs12280928; rs7117213; rs16912972; rs16912981; rs11018522; rs12417166; rs7103781; rs12280693; rs11820834; rs10830245; rs1939262; rs12799347; rs7933595; rs10830248; rs12808219; rs7942587; rs12421746; rs12574987; rs7940368; rs4601783; rs16913084; rs12420864; rs12419071; rs7116589; rs16913095; rs10501698; rs11018549; rs12416958; rs7925659; rs7358330; rs12270717; rs12365043; rs12421030; rs12577992; rs16912983; rs11018555; rs12793071; rs11018545; rs11018535; rs16912966; rs11828655; rs7947052; rs11828731; rs12795158; rs3936992; rs1939263; rs9919546; rs4290229; rs660491; rs10830240; rs7933594; rs16912262; rs7117255; rs11821815; rs575429; rs10830249; rs6482999; rs1074304; rs10830244; rs11018542; rs11018548; rs17793678; rs645592; rs11018553; rs12799516; rs598769; rs10765199; rs4087499; rs16913089; rs10501699; rs16913011; rs1939251; rs4753214; rs7935604; rs11018543; rs12421505; rs10830239; rs12417327; rs11018532; rs7939929; rs6415994; rs2000555; rs12795171; rs7925468; rs2155148; rs7103787; rs16913040; rs11018562; rs1939252; rs12286618; rs7116973; rs12363772; rs10830243; rs12808283; rs7943159; rs16912994; rs7116716; rs7936840; rs9736253; rs4512823; rs3936623; rs7929736; rs11018539; rs535527; rs2155149; rs2155147; rs12803765; rs877072; rs10830247; rs10830246; rs7934212; rs12417026; rs7117974; rs6485980; rs10830238; rs12799768; rs7924913; rs525883; rs12418178; rs12288824; rs12792733; rs12799349; rs4542415; rs12792959; rs1892924; rs4547091; rs1799989; rs5021654; rs7930949; rs7940945; rs28940878; rs13312744; rs13312739; rs34297847; rs34878847; rs13312741; rs28940880; rs11545463; rs13312740; rs11826502; rs11824499; rs11545464; rs28940877; rs28940879; rs36006590; rs28940876; rs28940881; rs13312743; rs1939261; rs1939260; rs35541275; rs1800421; rs13312738; rs34814690; rs11453031; rs36041295; rs1939254; rs7121593; rs34175287; rs7951381; rs11018554; rs35062445; rs34947445; rs34656455; rs11411684; rs28634864; rs11018559; rs11018540; rs34017963; rs34698766; rs2134299; rs12788302; rs35963892; rs12786392; rs11018547; rs36137175; rs1060297; rs34202080; rs12788985; rs12365772; rs12578000; rs35218219; rs12788993; rs11018560; rs4121402; rs35026809; rs35311585; rs4121397; rs5793396; rs17852431; rs36124916; rs7929045; rs4561218; rs34486762; rs34289520; rs35905469; rs34003066; rs4429061; rs34661861; rs4987235; rs12796520; rs34703992; rs28578270; rs34373463; rs11018523; rs34739346; rs12786829; rs905283; rs5793397; rs12277937; rs11018527; rs34899701; rs34429128; rs34758368; rs34773602; rs1074303; rs36055732; rs12803508; rs13312742; rs16913082; rs36007597; rs12804213; rs35654391; rs10526067; rs28620862; rs12791524; rs35555968; rs11018536; rs7396600; rs10551522; rs34876778; rs11018556; rs1783963; rs35928779; rs7946027; rs12786751; rs7924312; rs4079453; rs4087500; rs3907204; rs35930733; rs35724269; rs12804722; rs7934646; rs35477235; rs35801536; rs34425156; rs41320146; rs1939257; rs12789480; rs34675404; rs12805094; rs11018550; rs35501966; rs35514600; rs34903891; rs12803535; rs12294360; rs4512825; rs34634444; rs592486; rs17852430; rs35663695; rs10573250; rs12788260; rs35032790; rs34621048; rs12099254; rs34873297; rs694934; rs34700959; rs4611200; rs7127196; rs35103430; rs35217407; rs35464565; rs5793398; rs10547762; rs16913085; rs34422026; rs7928821; rs35222097; rs34604882; rs609630; rs12796336; rs10671315; rs35457014; rs12271965; rs7946211; rs12805443; rs35434176; rs12789834; rs4121400; rs12146614; rs35105852; rs3907205; rs35774080; rs35744603; rs1939256; rs35428928; rs648871; rs35937494; rs582480; rs12786390; rs625401; rs11018563; rs12797237; rs636613; rs12788232; rs12807511; rs35959534; rs34067617; rs36098386; rs12788214; rs35518533; rs7112858; rs5793399; rs34584385; rs35607520; rs11018557; rs12805030; rs12574349; rs2008320; rs516696; rs35526885; rs12805221; rs35342940; rs11018551; rs1847136; rs11018538; rs11018546; rs34530512; rs34857319; rs35029283; rs11018534; rs1074305; rs35523924; rs12789159; rs35300336; rs11517465; rs603082; rs34295137; rs28826427; rs34469199; rs12787683; rs35430241; rs35115224; rs35597809; rs12295166; rs4614456; rs905281; rs10583155; rs35770150; rs34754918; rs7924785; rs35581621; rs1987513; rs12786588; rs2173998; rs33998063; rs12285584; rs12805029; rs11381844; rs12099178; rs11018558; rs28625671; rs4121398; rs35531191; rs649687; rs7927845; rs34029150; rs35008750; rs7122606; rs475629; rs34865967; rs34625776; rs35549872; rs4121399; rs35764186; rs3834913; rs7483274; rs11018526; rs12786201; rs1939259; rs28625370; rs35804290; rs34388247; rs16912961; rs35195697; rs7105284; rs35638921; rs7119171; rs12364170; rs10691193; rs28521275; rs11374501; rs10830237; rs11824466; rs11827921; rs12795279; rs1954771; rs35402334; rs7949856; rs949537; rs949538

# Metabolic_Enzyme_5_General_References:
1903356; 2823263; 2499655; 1711223; 8340755; 11153699; 2480811; 2504160; 11214319; 8477259; 10094567; 2342539; 1970634; 1903591; 1642278; 1899321; 1900309; 1943686; 1487241; 7902671; 8128955; 7955413; 8644824; 9158138; 9259202; 10987646; 10571953; 11295837; 11858948

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5631

# Metabolic_Enzyme_6_Name:
Retina-specific copper amine oxidase precursor

# Metabolic_Enzyme_6_Synonyms:
RAO; Amine oxidase [copper-containing]

# Metabolic_Enzyme_6_Gene_Name:
AOC2

# Metabolic_Enzyme_6_Protein_Sequence:
>Retinaspecific copper amine oxidase precursor
MHLKIVLAFLALSLITIFALAYVLLTSPGGSSQPPHCPSVSHRAQPWPHPGQSQLFADLS
REELTAVMRFLTQRLGPGLVDAAQAQPSDNCIFSVELQLPPKAAALAHLDRGSPPPAREA
LAIVLFGGQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLRAEFTQMWRHLK
EVELPKAPIFLSSTFNYNGSTLAAVHATPRGLRSGDRATWMALYHNISGVGLFLHPVGLE
LLLDHRALDPAHWTVQQVFYLGHYYADLGQLEREFKSGRLEVVRVPLPPPNGASSLRSRN
SPGPLPPLQFSPQGSQYSVQGNLVVSSLWSFTFGHGVFSGLRIFDVRFQGERIAYEVSVQ
ECVSIYGADSPKTMLTRYLDSSFGLGRNSRGLVRGVDCPYQATMVDIHILVGKGAVQLLP
GAVCVFEEAQGLPLRRHHNYLQNHFYGGLASSALVVRSVSSVGNYDYIWDFVLYPNGALE
GRVHATGYINTAFLKGGEEGLLFGNRVGERVLGTVHTHAFHFKLDLDVAGLKNWVVAEDV
VFKPVAAPWNPEHWLQRPQLTRQVLGKEDLTAFSLGSPLPRYLYLASNQTNAWGHQRGYR
IQIHSPLGIHIPLESDMERALSWGRYQLVVTQRKEEESQSSSIYHQNDIWTPTVTFADFI
NNETLLGEDLVAWVTASFLHIPHAEDIPNTVTLGNRVGFLLRPYNFFDEDPSIFSPGSVY
FEKGQDAGLCSINPVACLPDLAACVPDLPPFSYHGF

# Metabolic_Enzyme_6_Number_of_Residues:
756

# Metabolic_Enzyme_6_Molecular_Weight:
83674

# Metabolic_Enzyme_6_Theoretical_pI:
7.03

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_6_Specific_Function:
May be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine

# Metabolic_Enzyme_6_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_6_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_6_Signals:
1-32

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_6_GenBank_ID_Protein:
1906806

# Metabolic_Enzyme_6_SwissProt_ID:
AOC2_HUMAN (O75106)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
AOC2

# Metabolic_Enzyme_6_Geneatlas_id:
AOC2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:549

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Membrane

# Metabolic_Enzyme_6_Gene_Sequence:
>2190 bp
ATGCATCTCAAGATAGTCCTGGCGTTCCTGGCACTGTCCCTCATTACCATCTTTGCCCTG
GCCTATGTTTTGCTGACCAGCCCAGGTGGTTCCAGCCAGCCTCCCCACTGCCCCTCTGTA
TCCCATAGGGCCCAGCCCTGGCCACACCCTGGCCAGAGCCAGCTGTTTGCAGACCTGAGC
CGAGAGGAGTTGACAGCTGTGATGCGCTTTCTGACCCAGCGGCTGGGGCCAGGGCTGGTG
GACGCAGCCCAGGCTCAGCCCTCGGACAACTGCATCTTCTCAGTGGAGCTGCAGCTGCCC
CCCAAGGCTGCAGCCCTGGCCCACCTGGACAGGGGGAGCCCCCCACCTGCCCGGGAGGCA
CTGGCCATCGTCCTCTTTGGTGGACAACCCCAACCCAATGTGAGTGAGCTGGTGGTGGGG
CCGCTGCCTCACCCCTCGTACATGCGGGATGTGACTGTGGAGCGTCACGGCGGGCCCCTG
CCCTATCACCGTCGCCCGGTGCTGAGAGCTGAGTTTACACAGATGTGGAGGCATCTGAAA
GATGTGGAGCTACCCAAGGCACCCATCTTCCTGTCGTCCACCTTCAACTACAATGGCTCT
ACCCTGGCAGCTGTGCATGCCACCCCTCGGGGCTTGCGCTCAAGGGAACGAACTACCTGG
ATTGGCCTCTACCATAACATCTCAGGGGTTGGTCTTTTCCTTCACCCCGTGGGGCTGGAG
CTACTACTGGACCACAGGGCCCTGGACCCTGCCCACTGGACTGTCCAGCAGGTCTTCTAC
CTTGGGCACTACTATGCAGACTTGGGCCAGTTGGAACGGGAGTTTAAGTCTGGCCGGTTG
GAAGTGGTTAGAGTCCCTCTACCTCCACCAAATGGAGCTTCATCCCTGAGGTCTCGGAAC
TCTCCAGGTCCTCTTCCCCCTCTTCAGTTCTCGCCCCAGGGTTCCCAGTACAGTGTGCAA
GGAAACCTGGTGGTATCCTCCCTCTGGTCATTTACCTTTGGCCATGGGGTGTTCAGCGGC
CTGAGGATTTTTGATGTTCGGTTCCAGGGTGAGCGAATAGCCTATGAAGTCAGTGTCCAG
GAGTGTGTATCTATCTATGGTGCCGATTCACCCAAGACGATGCTGACTCGCTATTTGGAT
AGCAGCTTTGGACTCGGCCGTAACAGCCGAGGCTTGGTGCGGGGAGTGGACTGCCCCTAT
CAAGCCACGATGGTGGACATCCATATATTAGTGGGCAAAGGGGCAGTCCAGCTGCTTCCA
GGGGCTGTGTGTGTATTTGAGGAAGCCCAGGGACTGCCCCTTCGAAGGCACCACAATTAC
CTTCAAAATCATTTCTATGGTGGTTTGGCCAGCTCAGCCCTTGTGGTCAGGTCTGTGTCA
TCTGTGGGCAACTATGACTACATTTGGGACTTTGTGTTGTACCCAAATGGGGCACTTGAA
GGGCGGGTCCATGCCACGGGTTATATCAACACAGCTTTCCTGAAAGGGGGAGAGGAGGGC
CTCCTCTTTGGGAACCGTGTGGGGGAAAGAGTGCTGGGAACGGTGCACACACATGCCTTC
CACTTCAAGCTGGACCTGGATGTGGCAGGGCTGAAAAACTGGGTGGTAGCTGAAGACGTG
GTGTTTAAACCTGTGGCTGCCCCCTGGAACCCGGAGCACTGGCTACAGCGCCCACAGCTG
ACTCGGCAGGTCCTGGGAAAGGAGGACCTGACAGCTTTTTCCTTGGGAAGCCCCCTACCC
CGCTACCTCTACCTGGCTAGCAACCAGACTAATGCGTGGGGTCACCAGCGCGGATACCAG
CTTGTGGTGACCCAGAGAAAGGAGGAGGAGTCACAGAGCAGTAGCATCTATCACCAGAAT
GACATCTGGACACCCACAGTTACCTTTGCTGACTTCATCAACAATGAAACCCTCTTAGGA
GAGGATCTGGTGGCTTGGGTCACAGCCAGCTTCCTGCACATTCCCCATGCCGAGGACATC
CCAAACACAGTGACTCTGGGGAACAGAGTTGGCTTCTTGCTCCGACCCTATAACTTCTTT
GATGAGGACCCCTCCATCTTCTCCCCTGGCAGTGTGTACTTTGAGAAGGGCCAGGATGCT
GGGCTCTGCAGCATCAATCCTGTGGCCTGCCTCCCCGACCTGGCAGCCTGTGTCCCGGAC
TTACCCCCTTTCTCTTACCACGGCTTCTAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
D88213

# Metabolic_Enzyme_6_Chromosome_Location:
Not Available

# Metabolic_Enzyme_6_Locus:
Not Available

# Metabolic_Enzyme_6_SNPs:
Not Available

# Metabolic_Enzyme_6_General_References:
9119395; 9722954

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5401

# Metabolic_Enzyme_7_Name:
Amine oxidase [flavin-containing] A

# Metabolic_Enzyme_7_Synonyms:
Monoamine oxidase type A; MAO-A

# Metabolic_Enzyme_7_Gene_Name:
MAOA

# Metabolic_Enzyme_7_Protein_Sequence:
>Amine oxidase flavincontaining 
AMENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEH
VDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPI
AYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVN
INVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVK
LNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLP
MGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKAD
RLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQY
GRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESK
DVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS

# Metabolic_Enzyme_7_Number_of_Residues:
527

# Metabolic_Enzyme_7_Molecular_Weight:
59682

# Metabolic_Enzyme_7_Theoretical_pI:
7.96

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine

# Metabolic_Enzyme_7_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_7_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF01593:Amino_oxidase

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
498-518

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.4.3.4

# Metabolic_Enzyme_7_GenBank_ID_Protein:
187353

# Metabolic_Enzyme_7_SwissProt_ID:
AOFA_HUMAN (P21397)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
MAOA

# Metabolic_Enzyme_7_Geneatlas_id:
MAOA

# Metabolic_Enzyme_7_hgnc_id:
HGNC:6833

# Metabolic_Enzyme_7_PDB_ID:
1O5W

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type IV membrane protein; cytoplasmic side

# Metabolic_Enzyme_7_Gene_Sequence:
>1584 bp
ATGGAGAATCAAGAGAAGGCGAGTATCGCGGGCCACATGTTCGACGTAGTCGTGATCGGA
GGTGGCATTTCAGGACTATCTGCTGCCAAACTCTTGACTGAATATGGCGTTAGTGTTTTG
GTTTTAGAAGCTCGGGACAGGGTTGGAGGAAGAACATATACTATAAGGAATGAGCATGTT
GATTACGTAGATGTTGGTGGAGCTTATGTGGGACCAACCCAAAACAGAATCTTACGCTTG
TCTAAGGAGCTGGGCATAGAGACTTACAAAGTGAATGTCAGTGAGCGTCTCGTTCAATAT
GTCAAGGGGAAAACATATCCATTTCGGGGCGCCTTTCCACCAGTATGGAATCCCATTGCA
TATTTGGATTACAATAATCTGTGGAGGACAATAGATAACATGGGGAAGGAGATTCCAACT
GATGCACCCTGGGAGGCTCAACATGCTGACAAATGGGACAAAATGACCATGAAAGAGCTC
ATTGACAAAATCTGCTGGACAAAGACTGCTAGGCGGTTTGCTTATCTTTTTGTGAATATC
AATGTGACCTCTGAGCCTCACGAAGTGTCTGCCCTGTGGTTCTTGTGGTATGTGAAGCAG
TGCGGGGGCACCACTCGGATATTCTCTGTCACCAATGGTGGCCAGGAACGGAAGTTTGTA
GGTGGATCTGGTCAAGTGAGCGAACGGATAATGGACCTCCTCGGAGACCAAGTGAAGCTG
AACCATCCTGTCACTCACGTTGACCAGTCAAGTGACAACATCATCATAGAGACGCTGAAC
CATGAACATTATGAGTGCAAATACGTAATTAATGCGATCCCTCCGACCTTGACTGCCAAG
ATTCACTTCAGACCAGAGCTTCCAGCAGAGAGAAACCAGTTAATTCAGCGGCTTCCAATG
GGAGCTGTCATTAAGTGCATGATGTATTACAAGGAGGCCTTCTGGAAGAAGAAGGATTAC
TGTGGCTGCATGATCATTGAAGATGAAGATGCTCCAATTTCAATAACCTTGGATGACACC
AAGCCTGATGGGTCACTGCCTGCCATCATGGGCTTCATTCTTGCCCGGAAAGCTGATCGA
CTTGCTAAGCTACATAAGGAAATAAGGAAGAAGAAAATCTGTGAGCTCTATGCCAAAGTG
CTGGGATCCCAAGAAGCTTTACATCCAGTGCATTATGAAGAGAAGAACTGGTGTGAGGAG
CAGTACTCTGGGGGCTGCTACACGGCCTACTTCCCTCCTGGGATCATGACTCAATATGGA
AGGGTGATTCGTCAACCCGTGGGCAGGATTTTCTTTGCGGGCACAGAGACTGCCACAAAG
TGGAGCGGCTACATGGAAGGGGCAGTTGAGGCTGGAGAACGAGCAGCTAGGGAGGTCTTA
AATGGTCTCGGGAAGGTGACCGAGAAAGATATCTGGGTACAAGAACCTGAATCAAAGGAC
GTTCCAGCGGTAGAAATCACCCACACCTTCTGGGAAAGGAACCTGCCCTCTGTTTCTGGC
CTGCTGAAGATCATTGGATTTTCCACATCAGTAACTGCCCTGGGGTTTGTGCTGTACAAA
TACAAGCTCCTGCCACGGTCTTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
M68840

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_7_Locus:
Xp11.3

# Metabolic_Enzyme_7_SNPs:
rs6323; rs1137070; rs1800464; rs3027407; rs2072743; rs1465107; rs979605; rs3027397; rs2205718; rs979606; rs909525; rs3788862; rs2283725; rs2235186; rs5906883; rs5906974; rs3027403; rs3027405; rs6520894; rs3027401; rs3788863; rs2235185; rs1465108; rs5953385; rs2310883; rs6609250; rs3027398; rs5906938; rs5906729; rs6520897; rs5906893; rs17146683; rs7885398; rs3027402; rs5905702; rs5906957; rs2072744; rs5906915; rs4824498; rs9723729; rs3027406; rs5906973; rs3027400; rs2064697; rs5906914; rs5906901; rs12689575; rs2239448; rs2064696; rs3027392; rs2238968; rs17146660; rs12688067; rs9723711; rs7051042; rs5905859; rs7887158; rs2064698; rs7882699; rs3027399; rs9330645; rs2283724; rs9723795; rs3027404; rs9724332; rs5953210; rs1803986; rs1799835; rs1800466; rs1803987; rs1800465; rs7065428; rs3027408; rs11544798; rs12839550; rs10545588; rs5952250; rs3027394; rs34390290; rs1800659; rs10560402; rs12854463; rs35759188; rs28375424; rs7059300; rs12687961; rs35784967; rs35254233; rs34894015; rs35215664; rs35546327; rs3027396; rs12556694; rs7057038; rs12687974; rs9780693; rs7892282; rs5902323; rs28593700; rs35600375; rs35488042; rs35200424; rs5902326; rs5905823; rs12843650; rs34941362; rs34841794; rs12833632; rs12863636; rs3030071; rs12398290; rs10548364; rs28401570; rs4604608; rs28449781; rs6609256; rs6610845; rs12833929; rs12843268; rs2310884; rs5905830; rs6610846; rs7054032; rs7880230; rs41303697; rs3810709; rs2179098; rs12399572; rs12840448; rs5902324; rs28556796; rs5905812; rs12847449; rs28619059; rs10652560; rs6610837; rs10548363; rs5905418; rs2283726; rs33910552; rs3027395; rs28637527; rs5906971; rs28439389; rs35235270; rs3027393; rs28583596; rs6610842; rs6520893; rs35336176; rs5906913; rs12849959; rs36036121; rs5905822; rs5902325; rs5905809; rs11471949; rs6610834; rs3838195; rs3216387; rs33946653; rs6609255; rs35445276; rs7061874; rs17436054; rs1181275; rs12843533; rs2064070; rs3027409; rs3027410; rs3027414; rs3027415; rs3027416; rs3027417; rs4301558; rs4570308; rs5905613; rs6609257; rs6609258; rs7052785; rs727884

# Metabolic_Enzyme_7_General_References:
3418353; 3387449; 1432104; 8584674; 7519662; 3178846; 2764901; 11812236

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5485

# Metabolic_Enzyme_8_Name:
Dopamine beta-hydroxylase precursor

# Metabolic_Enzyme_8_Synonyms:
Dopamine beta- monooxygenase

# Metabolic_Enzyme_8_Gene_Name:
DBH

# Metabolic_Enzyme_8_Protein_Sequence:
>Dopamine betahydroxylase precursor
MREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYHIPLDPEGSLELSWNVSYTQEAIHF
QLLVRRLKAG
VLFGMSDRGELENADLVVLWTDGDTAYFADAWSDQKGQIHLDPQQDYQL
LQVQRTPEGLTLLFKRPFGTC
DPKDYLIEDGTVHLVYGILEEPFRSLEAINGSGLQMGL
QRVQLLKPNIPEPELPSDACTMEVQAPNIQIP
SQETTYWCYIKELPKGFSRHHIIKYEP
IVTKGNEALVHHMEVFQCAPEMDSVPHFSGPCDSKMKPDRLNY
CRHVLAAWALGAKAFY
YPEEAGLAFGGPGSSRYLRLEVHYHNPLVIEGRNDSSGIRLYYTAKLRRFNAGI
MELGL
VYTPVMAIPPRETAFILTGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKVVTVLVRDGR
EWEIV
NQDNHYSPHFQEIRMLKKVVSVHPGDVLITSCTYNTEDRELATVGGFGILEEMC
VNYVHYYPQTQLELCK
SAVDAGFLQKYFHLINRFNNEDVCTCPQASVSQQFTSVPWNSF
NRDVLKALYSFAPISMHCNKSSAVRFQ
GEWNLQPLPKVISTLEEPTPQCPTSQGRSPAG
PTVVSIGGGKG

# Metabolic_Enzyme_8_Number_of_Residues:
603

# Metabolic_Enzyme_8_Molecular_Weight:
67614

# Metabolic_Enzyme_8_Theoretical_pI:
6.31

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
Function:  dopamine beta-monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  catecholamine metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  histidine family amino acid metabolism
Process:  histidine metabolism
Process:  histidine catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
Conversion of dopamine to noradrenaline

# Metabolic_Enzyme_8_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_8_Reaction:
3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF03712:Cu2_monoox_C;
PF01082:Cu2_monooxygen;
PF03351:DOMON

# Metabolic_Enzyme_8_Signals:
1-25

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.14.17.1

# Metabolic_Enzyme_8_GenBank_ID_Protein:
30474

# Metabolic_Enzyme_8_SwissProt_ID:
DOPO_HUMAN (P09172)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
DBH

# Metabolic_Enzyme_8_Geneatlas_id:
DBH

# Metabolic_Enzyme_8_hgnc_id:
HGNC:2689

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasmic vesicle; secretory vesicle; chromaffin granule. Cytoplasmic vesicle; secretory vesicle; chromaffin granule; chromaffin granule membrane. Note=Exists both in a soluble form (in chromaffin granules) and as membrane bound (the membrane bound form is anchored by an uncleaved signal peptide)

# Metabolic_Enzyme_8_Gene_Sequence:
>1812 bp

ATGCGGGAGGCAGCCTTCATGTACAGCACAGCAGTGGCCATCTTCCTGGTCATCCTGGT
GGCCGCACTGC
AGGGCTCGGCTCCCCGTGAGAGCCCCCTCCCCTATCACATCCCCCTGG
ACCCGGAGGGGTCCCTGGAGCT
CTCATGGAATGTCAGCTACACCCAGGAGGCCATCCAT
TTCCAGCTCCTGGTGCGGAGGCTCAAGGCTGGC
GTCCTGTTTGGGATGTCCGACCGTGG
CGAGCTTGAGAACGCAGATCTCGTGGTGCTCTGGACCGATGGGG
ACACTGCCTATTTTG
CGGACGCCTGGAGTGACCAGAAGGGGCAGATCCACCTGGATCCCCAGCAGGACTA
CCAG
CTGCTGCAGGTGCAGAGGACCCCAGAAGGCCTGACCCTGCTTTTCAAGAGGCCCTTTGGC
ACCTGC
GACCCCAAGGATTACCTCATTGAAGACGGCACTGTCCACTTGGTCTACGGGAT
CCTGGAGGAGCCGTTCC
GGTCACTGGAGGCCATCAACGGCTCGGGCCTGCAGATGGGGC
TGCAGAGGGTGCAGCTCCTGAAGCCCAA
TATCCCCGAACCGGAGTTGCCCTCAGACGCG
TGCACCATGGAGGTCCAAGCTCCCAATATCCAGATCCCC
AGCCAGGAGACCACGTACTG
GTGCTACATTAAGGAGCTTCCAAAGGGCTTCTCTCGGCACCACATTATCA
AGTACGAGC
CCATCGTCACCAAGGGCAATGAGGCCCTTGTCCACCACATGGAAGTCTTCCAGTGCGCCC
C
CGAGATGGACAGCGTCCCCCACTTCAGCGGGCCCTGCGACTCCAAGATGAAACCCGAC
CGCCTCAACTAC
TGCCGCCACGTGCTGGCCGCCTGGGCCCTGGGTGCCAAGGCATTTTA
CTACCCAGAGGAAGCCGGCCTTG
CCTTCGGGGGTCCAGGGTCCTCCAGATATCTCCGCC
TGGAAGTTCACTACCACAACCCACTGGTGATAGA
AGGACGAAACGACTCCTCAGGCATC
CGCTTGTACTACACAGCCAAGCTGCGGCGCTTCAACGCGGGGATC
ATGGAGCTGGGACT
GGTGTACACGCCAGTGATGGCCATTCCACCACGGGAGACCGCCTTCATCCTCACTG
GCT
ACTGCACGGACAAGTGCACCCAGCTGGCACTGCCTCCCTCCGGGATCCACATCTTCGCCT
CTCAGCT
CCACACACACCTGACTGGGAGAAAGGTGGTCACAGTGCTGGTCCGGGACGGC
CGGGAGTGGGAGATCGTG
AACCAGGACAATCACTACAGCCCTCACTTCCAGGAGATCCG
CATGTTGAAGAAGGTCGTGTCGGTCCATC
CGGGAGATGTGCTCATCACCTCCTGCACGT
ACAACACGGAAGACCGGGAGCTGGCCACAGTGGGGGGCTT
CGGGATCCTGGAGGAGATG
TGTGTCAACTACGTGCACTACTACCCCCAGACGCAGCTGGAGCTCTGCAAG
ACGGCTGT
GGACGCCGGCTTCCTGCAGAAGTACTTCCACCTCATCAACAGGTTCAACAACGAGGATGT
CT
GCACCTGCCCTCAGGCGTCCGTGTCTCAGCAGTTCACCTCTGTTCCCTGGAACTCCT
TCAACCGCGACGT
ACTGAAGGCCCTGTACAGCTTCGCGCCCATCTCCATGCACTGCAAC
AAGTCCTCAGCCGTCCGCTTCCAG
GGTGAATGGAACCTGCAGCCCCTGCCCAAGGTCAT
CTCCACACTGGAAGAGCCCACCCCACAGTGCCCCA
CCAGCCAGGGCCGAAGCCCTGCTG
GCCCCACCGTTGTCAGCATTGGTGGGGGCAAAGGCTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X13255

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_8_Locus:
9q34

# Metabolic_Enzyme_8_SNPs:
rs5324; rs5320; rs4531; rs5325; rs1108580; rs77905; rs5322; rs5318; rs2519154; rs2797849; rs1541333; rs6479643; rs1611126; rs1108581; rs7035577; rs2797853; rs7876027; rs1611122; rs1611130; rs1611124; rs3025399; rs12343735; rs3025405; rs2797852; rs1541332; rs3025383; rs2519143; rs1611120; rs1611128; rs1611123; rs1611119; rs7862391; rs3025411; rs3025395; rs9657707; rs3025391; rs2519151; rs3025382; rs2007153; rs2797855; rs2283123; rs2283124; rs3025388; rs2519155; rs2873804; rs1548364; rs80858; rs1611125; rs2797851; rs739398; rs3025390; rs3025410; rs129911; rs10993947; rs2283122; rs129913; rs3025413; rs1548367; rs10121827; rs3025401; rs12003344; rs3025387; rs3025403; rs2519153; rs2797854; rs7870239; rs3025393; rs129910; rs7864658; rs2005663; rs3025404; rs3025406; rs1611127; rs2797850; rs3025408; rs3739885; rs129908; rs2519157; rs129909; rs1611118; rs2519152; rs13284520; rs3025392; rs2519144; rs1611114; rs1611115; rs129883; rs129915; rs12002610; rs3025379; rs1611116; rs13306301; rs41316996; rs2797848; rs5319; rs5323; rs3025380; rs13306306; rs5321; rs13306303; rs17851478; rs35465867; rs3025400; rs35043556; rs3739886; rs35067824; rs3025381; rs28419319; rs3025415; rs1548365; rs28481752; rs5901024; rs3081166; rs13306307; rs3025385; rs1611129; rs35246072; rs12001868; rs2519156; rs35528158; rs11278217; rs11283016; rs13293282; rs3025428; rs34469151; rs13306302; rs3025430; rs35806215; rs35682711; rs28662126; rs7032535; rs34932746; rs12003763; rs3025416; rs3025427; rs3025384; rs3025426; rs1548366; rs3025389; rs4333676; rs3025398; rs28738882; rs13306308; rs1548368; rs129912; rs3025386; rs7027680; rs28698922; rs1611121; rs35688529; rs12005180; rs3025396; rs5901023; rs3025414; rs28534474; rs3025407; rs13306305; rs3025402; rs3025429; rs3025409; rs35808071; rs3025394; rs3025412; rs34553440; rs34242880; rs13298385; rs34701710; rs34498190; rs3025377; rs1611117; rs12684659; rs3025433; rs10993904; rs3025432; rs13285918; rs3025378; rs2797847; rs1076150; rs1076153; rs10993885; rs10993886; rs10993948; rs10993949; rs10993950; rs12337651; rs129882; rs129884; rs129885; rs129888; rs129914; rs129916; rs129917; rs129918; rs129919; rs129921; rs129922; rs129923; rs129924; rs129925; rs129926; rs129928; rs129929; rs129930; rs129931; rs17150766; rs1989787; rs2073833; rs2073835; rs2073836; rs2073837; rs2097628; rs2519145; rs2519147; rs2519148; rs2519149; rs2519764; rs2519765; rs3025369; rs3025370; rs3025371; rs3025372; rs3025373; rs3025374; rs3025375; rs3025376; rs3025417; rs3025418; rs3025419; rs3025421; rs3025422; rs3025423; rs3025424; rs3025425; rs3025431; rs3025434; rs3025435; rs3025436; rs3025437; rs3025438; rs3025439; rs3025440; rs3025441; rs3025443; rs6271; rs7043939; rs732833; rs7851898; rs7859358; rs9409875

# Metabolic_Enzyme_8_General_References:
2922261; 3443096; 8546710; 10490716; 10391209; 10391210; 11857564

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5627

# Metabolic_Enzyme_9_Name:
Amiloride-sensitive amine oxidase [copper-containing] precursor

# Metabolic_Enzyme_9_Synonyms:
Diamine oxidase; DAO; Amiloride-binding protein; ABP; Histaminase; Kidney amine oxidase; KAO

# Metabolic_Enzyme_9_Gene_Name:
ABP1

# Metabolic_Enzyme_9_Protein_Sequence:
>Amiloridesensitive amine oxidase coppercontaining precursor
MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS
TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP
GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR
CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG
KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP
RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG
GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE
MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH
ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT
NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSM
ADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWDPPVVFEQFLHNNENI
ENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRD
NGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV

# Metabolic_Enzyme_9_Number_of_Residues:
751

# Metabolic_Enzyme_9_Molecular_Weight:
85342

# Metabolic_Enzyme_9_Theoretical_pI:
7.01

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_9_Specific_Function:
Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function

# Metabolic_Enzyme_9_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_9_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_9_Signals:
1-19

# Metabolic_Enzyme_9_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_9_GenBank_ID_Protein:
177960

# Metabolic_Enzyme_9_SwissProt_ID:
ABP1_HUMAN (P19801)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
ABP1

# Metabolic_Enzyme_9_Geneatlas_id:
ABP1

# Metabolic_Enzyme_9_hgnc_id:
HGNC:80

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_9_Gene_Sequence:
>2142 bp
ATGCCGGCCCTGGGCTGGGCCGTGGCTGCCATCCTGATGCTGCAGACGGCCATGGCGGAG
CCCTCCCCGGGGACTCTGCCCAGGAAGGCAGGGGTGTTTTCAGACCTAAGCAACCAAGAG
CTGAAGGCAGTGCACAGCTTCCTCTGGTCCAAGAAGGAGCTGAGGCTGCAGCCCTCCAGT
ACCACCACCATGGCCAAGAACACCGTGTTTCTCATCGAGATGCTGCTGCCCAAGAAGTAC
CATGTGCTGAGGTTTCTGGATAAAGGTGAAAGGCATCCTGTGCGGGAAGCCCGTGCCGTC
ATCTTCTTTGGTGACCAGGAGCATCCCAATGTCACCGAGTTTGCTGTGGGGCCCCTGCCA
GGGCCCTGCTACATGCGAGCACTGTCCCCCAGGCCTGGGTACCAGTCCTCCTGGGCATCG
AGGCCCATCTCCACAGCAGAGTATGCCCTCCTCTACCACACCCTGCAGGAAGCCACCAAG
CCCCTGCATCAGTTCTTCCTCAATACCACAGGCTTCTCATTCCAAGACTGCCATGACAGA
TGCCTGGCCTTCACCGATGTGGCCCCCCGGGGTGTGGCTTCTGGCCAGCGCCGCAGTTGG
CTTATCATACAGCGCTATGTAGAAGGCTACTTTCTGCACCCCACTGGGCTGGAGCTCCTC
GTGGATCATGGGAGCACAGATGCTGGGCACTGGGCCGTGGAGCAGGTGTGGTACAACGGG
AAGTTCTATGGGAGCCCAGAGGAACTGGCACGGAAGTATGCAGATGGAGAGGTGGACGTG
GTGGTCCTGGAGGACCGCTGCCTGGGGGCAAGGGGCATGACAGCACAGAGGAGCCGGCCC
TCTTCTCCTCCACAAGCCCCGCGGGACTTTCCCCAGCCCCATCCATGTGAGCGGCCCCCG
CTTGGTCCAGCCCCACGGCCCTCGCTTCAGGCTGGAGGGCAACGCTGTGCTCTACGGCGG
CTGGAGCTTTGCCTTCCGGTGCGCTCCTCCTCCGGGCTGCAGGTCCTGAACGTGCACTTC
GGCGGAGAGCGCATTGCCTATGAGGTCAGCGTGCAAGAGGCAGTGGCGCTGTATGGAGGA
CACACACCTGCAGGCATGCAGACCAAGTACCTCGATGTCGGCTGGGGCCTGGGCAGCGTC
ACTCATGAGTTAGCCCCCGGCATCGACTGCCCGGAGACCGCCACCTTCCTGGACACTTTC
CACTACTATGATGCCGATGACCCGGTCCATTATCCCCGAGCCCTCTGCCTCTTTGAAATG
CCCACAGGGGTGCCCCTTCGGCGGCACTTTAATTCCAACTTTAAAGGTGGCTTCAACTTC
TATGCAGGGCTGAAGGGCCAGGTGCTGGTGCTGCGGACAACTTCAACTGTCTACAATTAT
GATTACATTTGGGACTTTATCTTCTACCCCAACGGGGTGATGGAGGCCAAGATGCATGCC
ACTGGCTACGTCCACGCCACCTTCTACACCCCCGAGGGCTGCGCACGGCACTCGCCTGCA
CACCCACCTGATTGGCAACATACACACTCACTTGTGCACTACCGCGTAGACCTGGATGTG
GCAGGCACCAAGAACAGCTTCCAGACACTGCAGATGAAGCTAGAAAACATCACCAACCCC
TGGAGCCCGAGACACCGCGTGGTCCAGCCAACTCTGGAGCAGACGCAGTACTCCTGGGAG
CGCCAGGCGGCCTTCCGCTTCAAAAGGAGGCTGCCCAAGTACCTGCTCTTTACCAGCCCC
CAGGAGAACCCCTGGGGCCACAAGCGCAGCTACCGCCTGCAGATCCACTCCATGGCCGAC
CAGGTGCTGCCCCCAGGCTGGCAGGAGGAGCAGGCCATCACCTGGGCAAGGTACCCCCTG
GCAGTGACCAAGTACCGGGAGTCAGAGCTGTGCAGCAGCAGCATCTACCACCAGAACGAC
CCCTGGGACCCGCCCGTGGTCTTTGAGCAGTTTCTTCACAACAACGAGAACATTGAAAAT
GAGGACCTGGTGGCCTGGGTGACGGTGGGCTTCCTGCACATCCCCCACTCAGAGGACATT
CCCAACACAGCCACACCTGGGAACTCCGTGGGCTTCCTGCTCCGGCCATTCAACTTCTTC
CCAGAGGACCCCTCCCCTCCCTGGCATCCAGAGACACTGTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
M55602

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_9_Locus:
7q34-q36

# Metabolic_Enzyme_9_SNPs:
rs10156191; rs1049742; rs35070995; rs1049793; rs1049748; rs10893; rs2071514; rs4725373; rs10441169; rs2268998; rs2071513; rs10156189; rs2268999; rs7786439; rs12539; rs12540862; rs11771771; rs2071515; rs11981415; rs11981217; rs3735076; rs10952294; rs4725968; rs2301257; rs2373876; rs10273373; rs2052130; rs2052129; rs2071517; rs17173645; rs2301256; rs4725375; rs4725970; rs35929142; rs6943147; rs41465145; rs6943420; rs10441176; rs7787074; rs7786420; rs7786526; rs35730790; rs10281706; rs35773682; rs8180720; rs13235597; rs13235592; rs13235484; rs34532106; rs4725969; rs4725374; rs4431514; rs35724462; rs10273148; rs34459590; rs34090933; rs35411492; rs34502771; rs1005389; rs1005390; rs10230025; rs10236489; rs10240738; rs10249948; rs10250599; rs10250704; rs10254616; rs10254802; rs10268640; rs11760854; rs11771001; rs11971392; rs11976328; rs11978239; rs12374688; rs12374823; rs12375106; rs1476867; rs2215563; rs2215564; rs4725376; rs4725377; rs4725971; rs6977081; rs6977381; rs7793572; rs7798657; rs887587; rs887588

# Metabolic_Enzyme_9_General_References:
2217167; 8182053; 8595053; 8144586

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
7975

# Metabolic_Enzyme_10_Name:
Tyrosine 3-monooxygenase

# Metabolic_Enzyme_10_Synonyms:
Tyrosine 3-hydroxylase; TH

# Metabolic_Enzyme_10_Gene_Name:
TH

# Metabolic_Enzyme_10_Protein_Sequence:
>Tyrosine 3monooxygenase
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTP
RSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPR
ATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVR
QVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEI
AFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNI
PQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCC
HELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQNGEVKAYG
AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYAS
RIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG

# Metabolic_Enzyme_10_Number_of_Residues:
528

# Metabolic_Enzyme_10_Molecular_Weight:
58525

# Metabolic_Enzyme_10_Theoretical_pI:
6.25

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  tyrosine 3-monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  catecholamine metabolism
Process:  catecholamine biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
Plays an important role in the physiology of adrenergic neurons

# Metabolic_Enzyme_10_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_10_Reaction:
L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00351:Biopterin_H

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 1.14.16.2

# Metabolic_Enzyme_10_GenBank_ID_Protein:
37127

# Metabolic_Enzyme_10_SwissProt_ID:
TY3H_HUMAN (P07101)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
TH

# Metabolic_Enzyme_10_Geneatlas_id:
TH

# Metabolic_Enzyme_10_hgnc_id:
HGNC:11782

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Not Available

# Metabolic_Enzyme_10_Gene_Sequence:
>1575 bp
ATGCCCACCCCCGACGCCACCACGCCACAGGCCAAGGGCTTCCGCAGGGCCGTGTCTGAG
CTGGACGCCAAGCAGGCAGAGGCCATCATGGGCGCCCCGGGGCCCAGCCTCACAGGCTCT
CCGTGGCCTGGAACTGCAGCCCCAGCTGCATCCTACACCCCCACCCCAAGGTCCCCGCGG
TTCATTGGGCGCAGGCAGAGCCTCATCGAGGACGCCCGCAAGGAGCGGGAGGCGGCGGTG
GCAGCAGCGGCCGCTGCAGTCCCCTCGGAGCCCGGGGACCCCCTGGAGGCTGTGGCCTTT
GAGGAGAAGGAGGGGAAGGCCGTGCTAAACCTGCTCTTCTCCCCGAGGGCCACCAAGCCC
TCGGCGCTGTCCCGAGCTGTGAAGGTGTTTGAGACGTTTGAAGCCAAAATCCACCATCTA
GAGACCCGGCCCGCCCAGAGGCCGCGAGCTGGGGGCCCCCACCTGGAGTACTTCGTGCGC
CTCGAGGTGCGCCGAGGGGACCTGGCCGCCCTGCTCAGTGGTGTGCGCCAGGTGTCAGAG
GACGTGCGCAGCCCCGCGGGGCCCAAGGTCCCCTGGTTCCCAAGAAAAGTGTCAGAGCTG
GACAAGTGTCATCACCTGGTCACCAAGTTCGACCCTGACCTGGACTTGGACCACCCGGGC
TTCTCGGACCAGGTGTACCGCCAGCGCAGGAAGCTGATTGCTGAGATCGCCTTCCAGTAC
AGGCACGGCGACCCGATTCCCCGTGTGGAGTACACCGCCGAGGAGATTGCCACCTGGAAG
GAGGTCTACACCACGCTGAAGGGCCTCTACGCCACGCACGCCTGCGGGGAGCACCTGGAG
GCCTTTGCTTTGCTGGAGCGCTTCAGCGGCTACCGGGAAGACAATATCCCCCAGCTGGAG
GACGTCTCCCGCTTCCTGAAGGAGCGCACGGGCTTCCAGCTGCGGCCTGTGGCCGGCCTG
CTGTCCGCCCGGGACTTCCTGGCCAGCCTGGCCTTCCGCGTGTTCCAGTGCACCCAGTAT
ATCCGCCACGCGTCCTCGCCCATGCACTCCCCTGAGCCGGACTGCTGCCACGAGCTGCTG
GGGCACGTGCCCATGCTGGCCGACCGCACCTTCGCGCAGTTCTCGCAGGACATTGGCCTG
GCGTCCCTGGGGGCCTCGGATGAGGAAATTGAGAAGCTGTCCACGCTGTCATGGTTCACG
GTGGAGTTCGGGCTGTGTAAGCAGAACGGGGAGGTGAAGGCCTATGGTGCCGGGCTGCTG
TCCTCCTACGGGGAGCTCCTGCACTGCCTGTCTGAGGAGCCTGAGATTCGGGCCTTCGAC
CCTGAGGCTGCGGCCGTGCAGCCCTACCAAGACCAGACGTACCAGTCAGTCTACTTCGTG
TCTGAGAGCTTCAGTGACGCCAAGGACAAGCTCAGGAGCTATGCCTCACGCATCCAGCGC
CCCTTCTCCGTGAAGTTCGACCCGTACACGCTGGCCATCGACGTGCTGGACAGCCCCCAG
GCCGTGCGGCGCTCCCTGGAGGGTGTCCAGGATGAGCTGGACACCCTTGCCCATGCGCTG
AGTGCCATTGGCTAG

# Metabolic_Enzyme_10_GenBank_ID_Gene:
Y00414

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_10_Locus:
11p15.5

# Metabolic_Enzyme_10_SNPs:
rs6356; rs7950050; rs6357; rs34510659; rs11826260; rs3842725; rs10840489; rs11825601; rs4074905; rs12419447; rs2070762; rs7482510; rs3842722; rs7925924; rs7942881; rs11826130; rs7483805; rs7483056; rs4072826; rs4072824; rs7925375; rs7479936; rs4072823; rs3842723; rs10743149; rs10770140; rs3842727; rs7119275; rs7115640; rs10840490; rs10770141; rs11564711; rs10840491; rs3842726; rs11042962; rs10770142; rs28934581; rs28934579; rs28934580; rs1800033; rs36097848; rs3842724; rs1799833; rs11564716; rs34723540; rs6578990; rs11042950; rs3842721; rs35596265; rs11564713; rs11564712; rs36009557; rs4930043; rs36010304; rs7925784; rs35996457; rs4072825; rs35125951; rs11564714; rs35444567; rs34965351; rs11564715; rs11564717; rs10734659; rs11564718; rs1800032; rs10743152; rs10770143; rs10840447; rs10840452; rs10840495; rs10840496; rs10840502; rs11042965; rs11042966; rs11042971; rs11042976; rs11042978; rs11042982; rs11042984; rs11042987; rs11564709; rs11564710; rs11564720; rs2000993; rs28494588; rs28933985; rs3842733; rs3842738; rs3842741; rs3842748; rs3842752; rs3842753; rs3842754; rs3842756; rs3842768; rs3842769; rs3842770; rs3842775; rs4929964; rs4929966; rs4930046; rs5505; rs5506; rs5507; rs6578993; rs689; rs7110099; rs7128097; rs7482891; rs7936868

# Metabolic_Enzyme_10_General_References:
2882428; 2888085; 2887169; 2902075; 2892893; 2896667; 7814018; 7789962; 8528210; 8817341; 9613851; 9754624; 9703425; 10391209; 11246459

# Metabolic_Enzyme_10_References:
16737161; 16786561; 16822979; 16832090

# Macromolecular_Interacting_Partner_1_ID:
7546

# Macromolecular_Interacting_Partner_1_Name:
Prolactin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
PRL

# Macromolecular_Interacting_Partner_1_Gene_Name:
PRL

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Prolactin precursor
MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN
EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG
LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
227

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
25876

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.99

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Prolactin acts primarily on the mammary gland by promoting lactation

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_1_Signals:
1-28

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
34211

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
PRL_HUMAN (P01236)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
PRL

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
PRL

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9445

# Macromolecular_Interacting_Partner_1_PDB_ID:
1RW5

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>684 bp
ATGAACATCAAAGGATCGCCATGGAAAGGGTCCCTCCTGCTGCTGCTGGTGTCAAACCTG
CTGCTGTGCCAGAGCGTGGCCCCCTTGCCCATCTGTCCCGGCGGGGCTGCCCGATGCCAG
GTGACCCTTCGAGACCTGTTTGACCGCGCCGTCGTCCTGTCCCACTACATCCATAACCTC
TCCTCAGAAATGTTCAGCGAATTCGATAAACGGTATACCCATGGCCGGGGGTTCATTACC
AAGGCCATCAACAGCTGCCACACTTCTTCCCTTGCCACCCCCGAAGACAAGGAGCAAGCC
CAACAGATGAATCAAAAAGACTTTCTGAGCCTGATAGTCAGCATATTGCGATCCTGGAAT
GAGCCTCTGTATCATCTGGTCACGGAAGTACGTGGTATGCAAGAAGCCCCGGAGGCTATC
CTATCCAAAGCTGTAGAGATTGAGGAGCAAACCAAACGGCTTCTAGAGGGCATGGAGCTG
ATAGTCAGCCAGGTTCATCCTGAAACCAAAGAAAATGAGATCTACCCTGTCTGGTCGGGA
CTTCCATCCCTGCAGATGGCTGATGAAGAGTCTCGCCTTTCTGCTTATTATAACCTGCTC
CACTGCCTACGCAGGGATTCACATAAAATCGACAATTATCTCAAGCTCCTGAAGTGCCGA
ATCATCCACAACAACAACTGCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00566

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_1_Locus:
6p22.2-p21.3

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
6260780; 6325171; 2050267; 6146607; 9266104; 925136; 1126929

# Macromolecular_Interacting_Partner_1_References:
16774500; 16857756; 16869884; 16930517

# Macromolecular_Interacting_Partner_2_ID:
7549

# Macromolecular_Interacting_Partner_2_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
INS

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_2_Signals:
1-24

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
INS

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_2_Locus:
11p15.5

# Macromolecular_Interacting_Partner_2_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_2_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_2_References:
16766383

# Macromolecular_Interacting_Partner_3_ID:
7086

# Macromolecular_Interacting_Partner_3_Name:
D(2) dopamine receptor

# Macromolecular_Interacting_Partner_3_Synonyms:
Dopamine D2 receptor

# Macromolecular_Interacting_Partner_3_Gene_Name:
DRD2

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>D2 dopamine receptor
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
443

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
50620

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
9.85

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  amine receptor activity
Function:  dopamine receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
38-60
72-97
109-130
152-174
187-210
374-397
406-429

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
563756

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
DRD2_HUMAN (P14416)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
DRD2

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
DRD2

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:3023

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>66 bp
ATGCGGCGGGAGCTGGAAGCCTCAAGCAGCCGGCGCCGTCTCTGCCCCCGGGGCCCTATG
GCTTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
M30625

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11q23

# Macromolecular_Interacting_Partner_3_SNPs:
rs1801028; rs1800496; rs6277; rs6275; rs1800499; rs4986918; rs4986921; rs4986923; rs1125394; rs2471857; rs1076563; rs7109615; rs4581480; rs7934416; rs7350522; rs6279; rs4245149; rs4586205; rs11214608; rs4245148; rs4436578; rs10891552; rs4938019; rs4648319; rs7131056; rs7125415; rs4245147; rs6278; rs1079596; rs1125393; rs4936271; rs4587762; rs4630328; rs4938017; rs6276; rs4936270; rs1116313; rs7122246; rs7102650; rs12574471; rs12800853; rs4274224; rs7103679; rs17529477; rs11601054; rs12364051; rs4936274; rs17115583; rs7131440; rs1079597; rs4460839; rs11214613; rs4620755; rs1079598; rs4350392; rs11214605; rs4245145; rs4648317; rs7122454; rs7118161; rs11214606; rs1076562; rs4938018; rs2471854; rs11214611; rs7948028; rs4245146; rs7937704; rs17115596; rs11608109; rs7131627; rs7131465; rs12805897; rs12417342; rs9282673; rs9282672; rs6274; rs7109897; rs17601612; rs34164777; rs7131681; rs10891550; rs35659571; rs2471851; rs7117847; rs10891551; rs12283680; rs7118174; rs12799083; rs12421616; rs10789943; rs7118024; rs2471856; rs2471850; rs11214607; rs11214612; rs12421264; rs2471848; rs10789944; rs10891553; rs7117915; rs12417718; rs4648318; rs4936272; rs4322431; rs2734837; rs1079594; rs2734841; rs1124493; rs1124491; rs2587548; rs1800498; rs1079595; rs2734836; rs2362873; rs1124492; rs2734833; rs1107162; rs1076560; rs2245805; rs1079727; rs2734838; rs2075654; rs2002453; rs2234690; rs2734839; rs2005313; rs12363125; rs1079721; rs11608185; rs4986920; rs12808482; rs2511521; rs2075652; rs2283265; rs2734835; rs2440390; rs2734831; rs2242592; rs2242591; rs10891549; rs1554929; rs1799978; rs2734842; rs12364283; rs2234689; rs1110977; rs11214604; rs35675212; rs34609702; rs34126713; rs35145680; rs2471855; rs11214610; rs1130354; rs34286726; rs34760436; rs7939472; rs10544310; rs3935565; rs35921774; rs34045234; rs36009253; rs36152573; rs35080812; rs1882765; rs36083757; rs12276545; rs10554769; rs12225915; rs34771705; rs36101312; rs11214616; rs7118628; rs6144513; rs7126289; rs4986922; rs12291794; rs10536949; rs35383923; rs35206875; rs34755690; rs34535530; rs34992190; rs34632468; rs11214615; rs11439751; rs6273; rs34735140; rs5794865; rs7131443; rs5794866; rs34063793; rs28685216; rs35826108; rs11214614; rs36102234; rs2471849; rs4337071; rs34179357; rs12798900; rs12576411; rs4379875; rs7930567; rs35751498; rs7116768; rs10652849; rs10707068; rs4533070; rs34322013; rs35033827; rs10891554; rs35610061; rs1124469; rs34684460; rs34083584; rs34674946; rs35319840; rs34986358; rs34554234; rs5794863; rs1110976; rs34216456; rs17115475; rs1076561; rs35352421; rs35299201; rs34135920; rs34113117; rs36019021; rs35608204; rs10622802; rs5794864; rs1962262; rs35579712; rs35685394; rs1124470; rs35761620; rs3060174; rs34914014; rs17505337; rs34525623; rs1110975; rs5794862; rs12098980; rs34482574; rs5013059; rs2587542; rs2734843; rs5013061; rs5013060; rs1554928; rs34681050; rs10547477; rs5794867; rs11351536; rs5013062; rs1799732; rs5794868; rs10637059; rs10547478; rs12281924; rs10546823; rs2734844; rs36070058; rs11214603; rs1003641; rs1005104; rs1005105; rs1005106; rs10891556; rs11214599; rs11214601; rs11214602; rs11214618; rs12422191; rs12794908; rs1800497; rs1882764; rs2242593; rs2471853; rs2511520; rs2516346; rs2587543; rs2587544; rs2587545; rs2587546; rs2587547; rs2587550; rs2587551; rs2587552; rs2587553; rs2734832; rs2734845; rs2734848; rs2859543; rs2859544; rs2859545; rs4254098; rs4307755; rs4424703; rs4483623; rs6589377; rs7110440

# Macromolecular_Interacting_Partner_3_General_References:
2533064; 2531656; 2138729; 2532362; 2137193; 2144985; 1363862; 1835903; 8471125; 10719223; 7902708; 10220438

# Macromolecular_Interacting_Partner_3_References:
16730695; 16750892; 16759339; 16856172

# Macromolecular_Interacting_Partner_4_ID:
7612

# Macromolecular_Interacting_Partner_4_Name:
Vascular endothelial growth factor A precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
VEGF-A; Vascular permeability factor; VPF

# Macromolecular_Interacting_Partner_4_Gene_Name:
VEGF

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Vascular endothelial growth factor A precursor
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD
IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM
SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPG
PHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
232

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
27043

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
9.08

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00341:PDGF

# Macromolecular_Interacting_Partner_4_Signals:
1-26

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
181971

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
VEGFA_HUMAN (P15692)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
VEGF

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
VEGF

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:12680

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell- associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>576 bp
ATGAACTTTCTGCTGTCTTGGGTGCATTGGAGCCTCGCCTTGCTGCTCTACCTCCACCAT
GCCAAGTGGTCCCAGGCTGCACCCATGGCAGAAGGAGGAGGGCAGAATCATCACGAAGTG
GTGAAGTTCATGGATGTCTATCAGCGCAGCTACTGCCATCCAATCGAGACCCTGGTGGAC
ATCTTCCAGGAGTACCCTGATGAGATCGAGTACATCTTCAAGCCATCCTGTGTGCCCCTG
ATGCGATGCGGGGGCTGCTGCAATGACGAGGGCCTGGAGTGTGTGCCCACTGAGGAGTCC
AACATCACCATGCAGATTATGCGGATCAAACCTCACCAAGGCCAGCACATAGGAGAGATG
AGCTTCCTACAGCACAACAAATGTGAATGCAGACCAAAGAAAGATAGAGCAAGACAAGAA
AATCCCTGTGGGCCTTGCTCAGAGCGGAGAAAGCATTTGTTTGTACAAGATCCGCAGACG
TGTAAATGTTCCTGCAAAAACACAGACTCGCGTTGCAAGGCGAGGCAGCTTGAGTTAAAC
GAACGTACTTGCAGATGTGACAAGCCGAGGCGGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
M32977

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_4_Locus:
6p12

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
2479986; 2479987; 1711045; 1791831; 1567395; 9054410; 9878851; 9450968; 10464055; 14574404; 7678805; 2584205; 10067980; 9207067; 9351807; 9922142; 9336848; 9634701; 11427521

# Macromolecular_Interacting_Partner_4_References:
16901966

# Macromolecular_Interacting_Partner_5_ID:
7615

# Macromolecular_Interacting_Partner_5_Name:
cAMP response element-binding protein

# Macromolecular_Interacting_Partner_5_Synonyms:
CREB

# Macromolecular_Interacting_Partner_5_Gene_Name:
CREB1

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>cAMP response elementbinding protein
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN
GQTVQVHGVIQAAQPSVIQSPQVQTVQSSCKDLKRLFSGTQISTIAESEDSQESVDSVTD
SQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSG
QYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQV
VVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAAREC
RRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
341

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
36688

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
5.24

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  protein binding
Function:  transcription factor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00170:bZIP_1;
PF02173:pKID

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
240429

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
CREB1_HUMAN (P16220)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
CREB1

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
CREB1

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:2345

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>984 bp
ATGACCATGGAATCTGGAGCCGAGAACCAGCAGAGTGGAGATGCAGCTGTAACAGAAGCT
GAAAACCAACAAATGACAGTTCAAGCCCAGCCACAGATTGCCACATTAGCCCAGGTATCT
ATGCCAGCAGCTCATGCAACATCATCTGCTCCCACCGTAACTCTAGTACAGCTGCCCAAT
GGGCAGACAGTTCAAGTCCATGGAGTCATTCAGGCGGCCCAGCCATCAGTTATTCAGTCT
CCACAAGTCCAAACAGTTCAGATTTCAACTATTGCAGAAAGTGAAGATTCACAGGAGTCA
GTGGATAGTGTAACTGATTCCCAAAAGCGAAGGGAAATTCTTTCAAGGAGGCCTTCCTAC
AGGAAAATTTTGAATGACTTATCTTCTGATGCACCAGGAGTGCCAAGGATTGAAGAAGAG
AAGTCTGAAGAGGAGACTTCAGCACCTGCCATCACCACTGTAACGGTGCCAACTCCAATT
TACCAAACTAGCAGTGGACAGTATATTGCCATTACCCAGGGAGGAGCAATACAGCTGGCT
AACAATGGTACCGATGGGGTACAGGGCCTGCAAACATTAACCATGACCAATGCAGCAGCC
ACTCAGCCGGGTACTACCATTCTACAGTATGCACAGACCACTGATGGACAGCAGATCTTA
GTGCCCAGCAACCAAGTTGTTGTTCAAGCTGCCTCTGGAGACGTACAAACATACCAGATT
CGCACAGCACCCACTAGCACTATTGCCCCTGGAGTTGTTATGGCATCCTCCCCAGCACTT
CCTACACAGCCTGCTGAAGAAGCAGCACGAAAGAGAGAGGTCCGTCTAATGAAGAACAGG
GAAGCAGCTCGAGAGTGTCGTAGAAAGAAGAAAGAATATGTGAAATGTTTAGAAAACAGA
GTGGCAGTGCTTGAAAATCAAAACAAGACATTGATTGAGGAGCTAAAAGCACTTAAGGAC
CTTTACTGCCACAAATCAGATTAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
S72459

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_5_Locus:
2q34

# Macromolecular_Interacting_Partner_5_SNPs:
rs2709357; rs2709356; rs889895; rs2551917; rs2709400; rs2551640; rs2709360; rs2042486; rs2551642; rs4675682; rs2709359; rs2551639; rs11883511; rs7590024; rs2709355; rs2551641; rs2709398; rs2360970; rs2042485; rs12466352; rs2709399; rs2709387; rs2551920; rs2551923; rs2464978; rs6740584; rs2254137; rs2551921; rs2551919; rs9679258; rs9288383; rs3770704; rs13397461; rs12694087; rs2551922; rs16839883; rs2194430; rs11904814; rs2709393; rs3730300; rs2247053; rs10199872; rs2551924; rs2551644; rs2059336; rs17811997; rs7603049; rs11692041; rs7570673; rs3730276; rs13393250; rs2551645; rs2709402; rs2709388; rs2464977; rs17515722; rs2551926; rs13398837; rs10932201; rs2952766; rs12477957; rs2709392; rs2464976; rs2551638; rs35349697; rs34884247; rs35342276; rs12992351; rs12467170; rs13422727; rs13016095; rs10561230; rs10202862; rs35952037; rs35924297; rs35303892; rs3836057; rs1050641; rs2709354; rs35153918; rs4024317; rs35539388; rs11356093; rs12998737; rs11397523; rs35506841; rs9677382; rs35379208; rs12992752; rs12470697; rs13029939; rs12467171; rs13422622; rs35711096; rs35714520; rs34172985; rs10598911; rs4024318; rs35004775; rs3836058; rs10568689; rs13422714; rs35282925; rs35047346; rs34797824; rs7582473; rs35896795; rs6729764; rs12614101; rs7603975; rs2709385; rs13018430; rs34411431; rs2709403; rs34628133; rs2551647; rs7589804; rs34775277; rs35762508; rs2551646; rs28853093; rs17515729; rs13431009; rs2551918; rs7558859; rs34583259; rs2551648; rs34550164; rs2551925; rs6715664; rs2709404; rs35735523; rs7576411; rs4101544; rs34903544; rs3951781; rs34242417; rs1064176; rs4675684; rs6705627; rs11311967; rs13412269; rs34309640; rs10185283; rs11684107; rs36108540; rs35955521; rs5838079; rs35019306; rs35728983; rs2709389; rs34275460; rs34379142; rs2709362; rs35000643; rs35261053; rs35119018; rs13409275; rs2709381; rs34177886; rs12478868; rs34145676; rs2709378; rs2551643; rs7588606; rs34127936; rs35865443; rs12998128; rs2709377; rs11319861; rs11335782; rs35907148; rs34317727; rs35318842; rs1045780; rs1045790; rs12999688; rs13029936; rs13386109; rs1806584; rs1806585; rs2551928; rs2551931; rs2709371; rs2709373; rs2709374; rs2709376; rs2709396; rs6785; rs7569963

# Macromolecular_Interacting_Partner_5_General_References:
2142528; 2196176; 1966745; 2974179; 1831258; 8381074; 7608156

# Macromolecular_Interacting_Partner_5_References:
16775132; 16793583

# Macromolecular_Interacting_Partner_6_ID:
7636

# Macromolecular_Interacting_Partner_6_Name:
Brain-derived neurotrophic factor precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
BDNF; Abrineurin

# Macromolecular_Interacting_Partner_6_Gene_Name:
BDNF

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Brainderived neurotrophic factor precursor
MTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLA
DTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAA
NMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQY
FYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCT
LTIKRGR

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
247

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
27818

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
9.01

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00243:NGF

# Macromolecular_Interacting_Partner_6_Signals:
1-18

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
179403

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
BDNF_HUMAN (P23560)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
BDNF

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
BDNF

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:1033

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>744 bp
ATGACCATCCTTTTCCTTACTATGGTTATTTCATACTTTGGTTGCATGAAGGCTGCCCCC
ATGAAAGAAGCAAACATCCGAGGACAAGGTGGCTTGGCCTACCCAGGTGTGCGGACCCAT
GGGACTCTGGAGAGCGTGAATGGGCCCAAGGCAGGTTCAAGAGGCTTGACATCATTGGCT
GACACTTTCGAACACGTGATAGAAGAGCTGTTGGATGAGGACCAGAAAGTTCGGCCCAAT
GAAGAAAACAATAAGGACGCAGACTTGTACACGTCCAGGGTGATGCTCAGTAGTCAAGTG
CCTTTGGAGCCTCCTCTTCTCTTTCTGCTGGAGGAATACAAAAATTACCTAGATGCTGCA
AACATGTCCATGAGGGTCCGGCGCCACTCTGACCCTGCCCGCCGAGGGGAGCTGAGCGTG
TGTGACAGTATTAGTGAGTGGGTAACGGCGGCAGACAAAAAGACTGCAGTGGACATGTCG
GGCGGGACGGTCACAGTCCTTGAAAAGGTCCCTGTATCAAAAGGCCAACTGAAGCAATAC
TTCTACGAGACCAAGTGCAATCCCATGGGTTACACAAAAGAAGGCTGCAGGGGCATAGAC
AAAAGGCATTGGAACTCCCAGTGCCGAACTACCCAGTCGTACGTGCGGGCCCTTACCATG
GATAGCAAAAAGAGAATTGGCTGGCGATTCATAAGGATAGACACTTCTTGTGTATGTACA
TTGACCATTAAAAGGGGAAGATAG

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
M37762

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_6_Locus:
11p13

# Macromolecular_Interacting_Partner_6_SNPs:
rs11030119; rs1013402; rs6484320; rs7103873; rs7104207; rs2030324; rs7103411; rs2030323; rs16917237; rs2049046; rs10767664; rs7482752; rs7934165; rs988748; rs962369; rs10835211; rs11030121; rs7127507; rs11826087; rs10767665; rs7483223; rs12293082; rs1158615; rs10835214; rs10835215; rs10767662; rs10160339; rs7944119; rs13306221; rs10219241; rs4923468; rs12575096; rs11030117; rs11030116; rs7931214; rs962368; rs10767666; rs11030112; rs36211437; rs4923466; rs6484321; rs12807356; rs36211436; rs12292980; rs11030120; rs7926362; rs2883187; rs7931755; rs12273363; rs36211441; rs28383487; rs4333984; rs1829469; rs34775831; rs12804186; rs10603158; rs4633417; rs982495; rs7937405; rs34640261; rs36186721; rs35882286; rs36211435; rs36154247; rs34000680; rs11500197; rs35365597; rs11428064; rs7930226; rs35038967; rs10626744; rs1949513; rs41282914; rs11030118; rs5790663; rs41282918; rs36137816; rs34782136; rs34097841; rs34006299; rs1967554; rs4505020; rs4378341; rs10835213; rs34137922; rs11375149; rs7942023; rs33973780; rs35952596; rs34379767; rs10767663; rs34590225; rs34710639; rs36080697; rs41282916; rs7126155; rs7943622; rs12790234; rs12099399; rs34043390; rs4542361; rs34845916; rs4385847; rs35397930; rs35092401; rs4258332; rs12801337; rs12790808; rs12289769; rs35935579; rs4922793; rs33943251; rs11607106; rs35791154; rs34321446; rs6484326; rs35699873; rs35168316; rs11030115; rs36162242; rs10835216; rs35920578; rs34006734; rs11030111; rs4390309; rs35641613; rs11030113; rs4923467; rs41274436; rs41274440; rs41274434; rs41274438; rs41274442; rs7929344; rs34194909; rs34578636; rs1048218; rs1048220; rs1048221; rs1048241; rs10501087; rs10767658; rs10767660; rs10767661; rs10835210; rs11030098; rs11030101; rs11030102; rs11030104; rs11030107; rs11030108; rs11030109; rs11030123; rs11819808; rs11825814; rs11826739; rs12273539; rs12284158; rs12284724; rs12288512; rs12291063; rs12291186; rs12419948; rs12790077; rs1401635; rs1491850; rs1491851; rs1519479; rs1519480; rs16917204; rs16917234; rs16917271; rs16917274; rs17309874; rs17309930; rs2049045; rs2049047; rs2049048; rs2203877; rs2353512; rs3178739; rs3750934; rs4923463; rs6265; rs7102921; rs7124442; rs727155; rs7931247; rs7940188; rs8192466; rs908867; rs925946; rs925947; rs925948

# Macromolecular_Interacting_Partner_6_General_References:
2236018; 1889806; 1339267; 2025430; 8527932; 11214319; 7703225; 11152678; 10391209; 14566559

# Macromolecular_Interacting_Partner_6_References:
16828062; 16890350; 17081696; 17116228

# Macromolecular_Interacting_Partner_7_ID:
6559

# Macromolecular_Interacting_Partner_7_Name:
Mitogen-activated protein kinase 3

# Macromolecular_Interacting_Partner_7_Synonyms:
Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAPK 1; p44-ERK1; ERT2; p44-MAPK; Microtubule- associated protein 2 kinase

# Macromolecular_Interacting_Partner_7_Gene_Name:
MAPK3

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Mitogenactivated protein kinase 3
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
379

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
43136

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.74

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00069:Pkinase

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
EC 2.7.11.24

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
31221

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
MK03_HUMAN (P27361)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
MAPK3

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
MAPK3

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:6877

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1140 bp
ATGGCGGCGGCGGCGGCTCAGGGGGGCGGGGGCGGGGAGCCCCGTAGAACCGAGGGGGTC
GGCCCGGGGGTCCCGGGGGAGGTGGAGATGGTGAAGGGGCAGCCGTTCGACGTGGGCCCG
CGCTACACGCAGTTGCAGTACATCGGCGAGGGCGCGTACGGCATGGTCAGCTCGGCCTAT
GACCACGTGCGCAAGACTCGCGTGGCCATCAAGAAGATCAGCCCCTTCGAACATCAGACC
TACTGCCAGCGCACGCTCCGGGAGATCCAGATCCTGCTGCGCTTCCGCCATGAGAATGTC
ATCGGCATCCGAGACATTCTGCGGGCGTCCACCCTGGAAGCCATGAGAGATGTCTACATT
GTGCAGGACCTGATGGAGACTGACCTGTACAAGTTGCTGAAAAGCCAGCAGCTGAGCAAT
GACCATATCTGCTACTTCCTCTACCAGATCCTGCGGGGCCTCAAGTACATCCACTCCGCC
AACGTGCTCCACCGAGATCTAAAGCCCTCCAACCTGCTCAGCAACACCACCTGCGACCTT
AAGATTTGTGATTTCGGCCTGGCCCGGATTGCCGATCCTGAGCATGACCACACCGGCTTC
CTGACGGAGTATGTGGCTACGCGCTGGTACCGGGCCCCAGAGATCATGCTGAACTCCAAG
GGCTATACCAAGTCCATCGACATCTGGTCTGTGGGCTGCATTCTGGCTGAGATGCTCTCT
AACCGGCCCATCTTCCCTGGCAAGCACTACCTGGATCAGCTCAACCACATTCTGGGCATC
CTGGGCTCCCCATCCCAGGAGGACCTGAATTGTATCATCAACATGAAGGCCCGAAACTAC
CTACAGTCTCTGCCCTCCAAGACCAAGGTGGCTTGGGCCAAGCTTTTCCCCAAGTCAGAC
TCCAAAGCCCTTGACCTGCTGGACCGGATGTTAACCTTTAACCCCAATAAACGGATCACA
GTGGAGGAAGCGCTGGCTCACCCCTACCTGGAGCAGTACTATGACCCGACGGATGAGCCA
GTGGCCGAGGAGCCCTTCACCTTCGCCATGGAGCTGGATGACCTACCTAAGGAGCGGCTG
AAGGAGCTCATCTTCCAGGAGACAGCACGCTTCCAGCCCGGAGTGCTGGAGGCCCCCTAG


# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
X60188

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_7_Locus:
16p11.2

# Macromolecular_Interacting_Partner_7_SNPs:
rs1143695; rs11865086; rs11864737; rs9921806; rs12922100; rs11863765; rs9930013; rs11546680; rs41292376; rs41291696; rs41280862; rs35691465; rs41280866; rs41280860; rs41280864; rs35666305; rs11644927; rs7199920; rs12918285; rs36084237; rs34799400; rs34564246; rs9940575; rs9940581; rs28529403; rs1042404; rs1062543; rs12924137; rs12930241; rs13569; rs1561414; rs2005219; rs3751867; rs7542; rs7698; rs8061772

# Macromolecular_Interacting_Partner_7_General_References:
7687743; 1540184; 1319925; 8794306

# Macromolecular_Interacting_Partner_7_References:
16871540; 17029599; 17114421

# Macromolecular_Interacting_Partner_8_ID:
7649

# Macromolecular_Interacting_Partner_8_Name:
Sodium-dependent serotonin transporter

# Macromolecular_Interacting_Partner_8_Synonyms:
5HT transporter; 5HTT

# Macromolecular_Interacting_Partner_8_Gene_Name:
SLC6A4

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Sodiumdependent serotonin transporter
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
630

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
70325

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
6.17

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  transporter activity
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF03491:5HT_transporter;
PF00209:SNF

# Macromolecular_Interacting_Partner_8_Signals:
None

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
88-108
116-135
160-180
253-271
280-297
333-350
362-383
417-436
464-482
498-518
539-558
577-595

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
36433

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
SC6A4_HUMAN (P31645)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
SLC6A4

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
SLC6A4

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:11050

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1893 bp
ATGGAGACGACGCCCTTGAATTCTCAGAAGCAGCTATCAGCGTGTGAAGATGGAGAAGAT
TGTCAGGAAAACGGAGTTCTACAGAAGGTTGTTCCCACCCCAGGGGACAAAGTGGAGTCC
GGGCAAATATCCAATGGGTACTCAGCAGTTCCAAGTCCTGGTGCGGGAGATGACACACGG
CACTCTATCCCAGCGACCACCACCACCCTAGTGGCTGAGCTTCATCAAGGGGAACGGGAG
ACCTGGGGCAAGAAGGTGGATTTCCTTCTCTCAGTGATTGGCTATGCTGTGGACCTGGGC
AATGTCTGGCGCTTCCCCTACATATGTTACCAGAATGGAGGGGGGGCATTCCTCCTCCCC
TACACCATCATGGCCATTTTTGGGGGAATCCCGCTCTTTTACATGGAGCTCGCACTGGGA
CAGTACCACCGAAATGGATGCATTTCAATATGGAGGAAAATCTGCCCGATTTTCAAAGGG
ATTGGTTATGCCATCTGCATCATTGCCTTTTACATTGCTTCCTACTACAACACCATCATG
GCCTGGGCGCTATACTACCTCATCTCCTCCTTCACGGACCAGCTGCCCTGGACCAGCTGC
AAGAACTCCTGGAACACTGGCAACTGCACCAATTACTTCTCCGAGGACAACATCACCTGG
ACCCTCCATTCCACGTCCCCTGCTGAAGAATTTTACACGCGCCACGTCCTGCAGATCCAC
CGGTCTAAGGGGCTCCAGGACCTGGGGGGCATCAGCTGGCAGCTGGCCCTCTGCATCATG
CTGATCTTCACTGTTATCTACTTCAGCATCTGGAAAGGCGTCAAGACCTCTGGCAAGGTG
GTGTGGGTGACAGCCACCTTCCCTTATATCATCCTTTCTGTCCTGCTGGTGAGGGGTGCC
ACCCTCCCTGGAGCCTGGAGGGGTGTTCTCTTCTACTTGAAACCCAATTGGCAGAAACTC
CTGGAGACAGGGGTGTGGATAGATGCAGCCGCTCAGATCTTCTTCTCTCTTGGTCCGGGC
TTTGGGGTCCTGCTGGCTTTTGCTAGCTACAACAAGTTCAACAACAACTGCTACCAAGAT
GCCCTGGTGACCAGCGTGGTGAACTGCATGACGAGCTTCGTTTCGGGATTTGTCATCTTC
ACAGTGCTCGGTTACATGGCTGAGATGAGGAATGAAGATGTGTCTGAGGTGGCCAAAGAC
GCAGGTCCCAGCCTCCTCTTCATCACGTATGCAGAAGCGATAGCCAACATGCCAGCGTCC
ACTTTCTTTGCCATCATCTTCTTTCTGATGTTAATCACGCTGGGCTTGGACAGCACGTTT
GCAGGCTTGGAGGGGGTGATCACGGCTGTGCTGGATGAGTTCCCACACGTCTGGGCCAAG
CGCCGGGAGCGGTTCGTGCTCGCCGTGGTCATCACCTGCTTCTTTGGATCCCTGGTCACC
CTGACTTTTGGAGGGGCCTACGTGGTGAAGCTGCTGGAGGAGTATGCCACGGGGCCCGCA
GTGCTCACTGTCGCGCTGATCGAAGCAGTCGCTGTGTCTTGGTTCTATGGCATCACTCAG
TTCTGCAGGGACGTGAAGGAAATGCTCGGCTTCAGCCCGGGGTGGTTCTGGAGGATCTGC
TGGGTGGCCATCAGCCCTCTGTTTCTCCTGTTCATCATTTGCAGTTTTCTGATGAGCCCG
CCACAACTACGACTTTTCCAATATAATTATCCTTACTGGAGTATCATCTTGGGTTACTGC
ATAGGAACCTCATCTTTCATTTGCATCCCCACATATATAGCTTATCGGTTGATCATCACT
CCAGGGACATTTAAAGAGCGTATTATTAAAAGTATTACCCCGGAGACACCAACAGAAATT
CCTTGTGGGGACATCCGCTTGAATGCTGTGTAA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
X70697

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_8_Locus:
17q11.1-q12

# Macromolecular_Interacting_Partner_8_SNPs:
rs6352; rs28914834; rs6355; rs2228673; rs28914833; rs28914832; rs33919215; rs28914828; rs6353; rs6354; rs1042173; rs2020936; rs25528; rs2020938; rs2066713; rs2020933; rs2020939; rs8071667; rs16965623; rs2020934; rs8080561; rs2020941; rs7212502; rs12150214; rs9896947; rs8072742; rs28914827; rs28914831; rs4251417; rs16965628; rs2020935; rs11872020; rs9903602; rs2020937; rs13306796; rs9903062; rs140701; rs2020942; rs717742; rs4325622; rs1872924; rs11080121; rs4583306; rs12449783; rs7216572; rs11653903; rs9303628; rs3794809; rs12450956; rs140700; rs3794808; rs4340379; rs1972305; rs8076005; rs13306794; rs28914830; rs11657536; rs16965581; rs11652121; rs9913038; rs7217065; rs9895500; rs28914829; rs34956669; rs11080122; rs34083002; rs2054848; rs34149483; rs2054847; rs2020932; rs7224199; rs8066731; rs25533; rs8066602; rs3813034; rs25531; rs28914823; rs956304; rs8081028; rs28914822; rs28914824; rs41274284; rs41274280; rs9911216; rs8073965; rs34102420; rs2020940; rs35517167; rs35444174; rs28914826; rs3783594; rs28409885; rs11417957; rs3783593; rs7342958; rs9892034; rs34751299; rs28914825; rs35393203; rs4514736; rs35697904; rs34871173; rs35206195; rs9910814; rs34035581; rs34500314; rs11472475; rs35153926; rs10438799; rs41274288; rs34332000; rs11300640; rs13306793; rs34121055; rs5819884; rs35370520; rs34764815; rs35721756; rs35842343; rs35788610; rs28441519; rs35246799; rs34828373; rs35600349; rs8071583; rs34459452; rs10438800; rs10688568; rs13306792; rs35886704; rs34954201; rs4636964; rs34210514; rs35659820; rs5819887; rs34185064; rs41274286; rs140702; rs34876533; rs10554393; rs34388196; rs9912813; rs7218956; rs5819885; rs745706; rs34405962; rs140698; rs41274282; rs5819882; rs35958391; rs3034289; rs35436651; rs9916159; rs5819886; rs13306795; rs34586405; rs10604158; rs9652882; rs34019821; rs5819883; rs34129293; rs35467658; rs35623510; rs10650671; rs34454216; rs140699; rs3829614; rs9906039; rs9915959; rs34921362; rs10646168; rs12150096; rs34070525; rs3064100; rs7210477; rs2321495; rs4795542; rs5819888; rs35519003; rs25532; rs35122351; rs28407157; rs35863620; rs34845320; rs25530; rs35514331; rs34542731; rs35263750; rs12150465; rs12452540; rs12945042; rs16965639; rs1906451; rs2020930; rs4392119; rs7214991; rs9894397; rs9896129

# Macromolecular_Interacting_Partner_8_General_References:
8452685; 7681602; 7684072; 10391209; 12869766

# Macromolecular_Interacting_Partner_8_References:
16882008; 16941426

# Macromolecular_Interacting_Partner_9_ID:
5977

# Macromolecular_Interacting_Partner_9_Name:
Adenylate cyclase type 7

# Macromolecular_Interacting_Partner_9_Synonyms:
Adenylate cyclase type VII; ATP pyrophosphate-lyase 7; Adenylyl cyclase 7

# Macromolecular_Interacting_Partner_9_Gene_Name:
ADCY7

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Adenylate cyclase type 7
MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPS
RHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAA
CAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQL
LANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAH
ISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKEL
VVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQ
VREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT
LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRA
SVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRS
EDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACA
SLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISER
VETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLP
YYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKP
NGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFET
MENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKE
GLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAH
IGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVAS
RMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN


# Macromolecular_Interacting_Partner_9_Number_of_Residues:
1080

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
120310

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
8.16

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  cyclase activity
Function:  adenylate cyclase activity
Function:  catalytic activity
Function:  lyase activity
Function:  phosphorus-oxygen lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  cyclic nucleotide biosynthesis
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_9_General_Function:
Signal transduction mechanisms 

# Macromolecular_Interacting_Partner_9_Specific_Function:
This is a membrane-bound, calcium-inhibitable adenylyl cyclase

# Macromolecular_Interacting_Partner_9_Pathway:
map00230  Purine metabolism

# Macromolecular_Interacting_Partner_9_Reaction:
ATP = 3',5'-cyclic AMP + diphosphate

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF06327:DUF1053;
PF00211:Guanylate_cyc

# Macromolecular_Interacting_Partner_9_Signals:
None

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
34-54
63-83
95-117
122-142
147-167
176-196
595-615
620-640
669-688
718-737
746-773
794-814

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
EC 4.6.1.1

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
40788941

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
ADCY7_HUMAN (P51828)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
ADCY7

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
ADCY7

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:238

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>3267 bp
CGACACGCGTGCCAAGGGTGGAGGATGCCAGCCAAGGGGCGCTACTTCCTCAACGAGGGC
GAGGAGGGCCCTGACCAAGATGCGCTCTACGAGAAGTACCAGCTCACCAGCCAGCATGGG
CCGCTGCTGCTCACGCTCCTGCTGGTGGCCGCCACTGCCTGCGTGGCCCTCATCATCATT
GCCTTCAGCCAGGGGGACCCCTCCAGACACCAGGCCATTCTGGGCATGGCGTTCCTGGTG
CTGGCGGTGTTTGCGGCCCTCTCTGTGCTGATGTACGTCGAGTGTCTCCTGCGGCGCTGG
CTCAGGGCCTTGGCGCTGCTCACCTGGGCCTGCTTGGTGGCGCTGGGCTATGTGCTGGTG
TTCGACGCATGGACAAAGGCGGCCTGTGCGTGGGAGCAGGTGCCCTTCTTCCTGTTCATT
GTCTTCGTGGTGTACACACTACTGCCCTTCAGCATGCGGGGCGCTGTCGCCGTTGGGGCC
GTCTCCACTGCCTCCCACCTCCTGGTGCTCGGTTCTTTGATGGGAGGCTTCACGACACCC
AGTGTCCGGGTGGGGCTGCAGCTGCTGGCCAACGCAGTCATCTTCCTGTGTGGGAACCTG
ACAGGCGCCTTCCACAAGCACCAAATGCAGGATGCGTCCCGGGACCTCTTCACCTACACT
GTGAAGTGCATCCAGATCCGCCGGAAGCTGCGCATCGAGAAGCGCCAGCAGGAGAACCTG
CTGCTGTCAGTGCTTCCGGCCCACATCTCCATGGGCATGAAGCTGGCCATCATCGAACGG
CTCAAGGAGCATGGTGACCGTCGCTGCATGCCTGACAACAACTTCCACAGCCTCTACGTC
AAGAGGCACCAGAATGTCAGCATCCTCTATGCGGACATCGTGGGCTTCACGCAGCTGGCC
AGCGACTGTTCTCCCAAGGAGCTGGTGGTGGTGCTGAATGAGCTCTTTGGCAAGTTCGAC
CAGATCGCCAAGGCCAACGAGTGCATGCGAATCAAGATCCTCGGCGACTGCTACTACTGT
GTATCGGGCCTGCCCGTGTCGCTGCCTACCCACGCCCGGAACTGCGTGAAGATGGGGCTG
GACATGTGCCAGGCCATCAAGCAGGTGCGGGAGGCCACGGGCGTGGACATCAACATGCGT
GTGGGCATACACTCGGGGAATGTGCTGTGCGGGGTCATCGGGCTGCGCAAGTGGCAGTAT
GACGTGTGGTCCCACGACGTGTCCCTGGCCAACCGGATGGAGGCAGCCGGAGTACCCGGC
CGGGTGCACATCACGGAGGCCACGCTAAAGCACCTGGACAAGGCGTACGAGGTGGAGGAT
GGGCACGGGCAGCAGCGGGACCCCTACCTCAAGGAGATGAACATCCGCACCTACCTGGTC
ATCGACCCCCGGAGCCAGCAGCCACCCCCGCCCAGCCAACACCTCCCCAGGCCCAAGGGG
GACGCGGCCCTGAAGATGCGGGCGTCAGTGCGCATGACCCGGTACCTCGAGTCCTGGGGG
GCGGCACGGCCCTTTGCACATCTCAACCACCGTGAGAGCGTGAGCAGTGGTGAGACCCAC
GTCCCCAACGGGCGGAGGCCTAAGAGCGTTCCCCAGCGCCACCGCCGGACCCCAGACAGA
AGCATGTCCCCCAAGGGGCGGTCGGAGGATGACTCGTACGATGACGAGATGCTGTCAGCC
ATTGAGGGGCTCAGCTCCACGAGGCCCTGCTGCTCCAAGTCCGATGACTTCTACACCTTT
GGGTCCATCTTCCTGGAGAAGGGCTTTGAGCGCGAGTACCGCCTGGCACCCATCCCCCGG
GCCCGCCACGACTTTGCCTGCGCCAGCCTGATCTTCGTCTGCATCCTGCTCGTCCATGTC
CTGCTCATGCCCAGGACGGCGGCACTGGGTGTGTCCTTCGGGCTGGTGGCCTGTGTACTG
GGGCTGGTGCTGGGCCTGTGCTTTGCCACCAAGTTCTCGAGGTGCTGCCCAGCTCGGGGG
ACGCTCTGCACTATCTCTGAGAGGGTGGAGACACAGCCCCTGCTGAGGCTGACCCTGGCC
GTCCTGACCATCGGCAGCCTGCTCACTGTGGCCATCATCAACCTGCCCCTGATGCCTTTC
CAAGTTCCAGAGCTGCCTGTTGGCAATGAGACAGGCCTACTGGCCGCGAGCAGCAAGACA
AGAGCCCTGTGTGAGCCCCTCCCGTACTACACCTGCAGCTGTGTCCTGGGCTTCATCGCC
TGCTCGGTCTTCCTGAGGATGAGCCTGGAGCCAAAGGTTGTGCTGCTGACAGTGGCCCTG
GTGGCCTACCTGGTGCTCTTCAACCTCTCCCCATGCTGGCAGTGGGACTGCTGCGGCCAA
GGCCTGGGCAACCTCACCAAGCCCAACGGCACCACCAGTGGCACCCCTAGCTGTTCCTGG
AAGGACCTGAAGACCATGACCAATTTCTACCTGGTCCTGTTCTACATCACCCTGCTTACA
CTCTCCAGACAGATTGACTATTACTGCCGCTTGGACTGCCTATGGAAGAAGAAGTTCAAG
AAGGAGCACGAGGAGTTTGAGACCATGGAGAACGTGAACCGCCTTCTTCTGGAGAACGTC
CTGCCAGCCCACGTGGCTGCCCACTTTATCGGTGACAAGTTAAACGAGGACTGGTACCAT
CAGTCCTATGACTGCGTCTGTGTCATGTTTGCCTCCGTGCCGGACTTCAAAGTGTTCTAC
ACAGAGTGCGATGTCAACAAAGAAGGGCTGGAGTGCCTACGCCTGCTCAATGAGATCATT
GCCGACTTCGACGAGCTCCTACTGAAGCCCAAGTTCAGCGGCGTGGAGAAGATCAAGACC
ATCGGCAGCACGTACATGGCAGCTGCAGGGCTCAGCGTCGCCTCAGGGCACGAGAACCAG
GAGCTGGAGCGGCAGCATGCCCACATTGGTGTCATGGTGGAGTTCAGCATCGCCCTGATG
AGTAAGCTGGACGGCATCAACAGGCACTCCTTCAACTCCTTCCGCCTCCGCGTCGGCATA
AACCATGGGCCTGTGATTGCTGGAGTGATTGGGGCCCGAAAACCTCAGTATGACATCTGG
GGAAACACTGTCAATGTGGCCAGCCGAATGGAAAGCACTGGAGAACTTGGGAAAATCCAG
GTTACCGAGGAGACCTGCACCATCCTCCAGGGCCTCGGGTACTCTTGTGAATGCCGTGGC
CTGATCAACGTCAAAGGCAAAGGCGAGCTGAGGACTTACTTTGTCTGTACGGACACTGCC
AAGTTTCAGGGGCTGGGGCTGAACTGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
D25538

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_9_Locus:
16q12-q13

# Macromolecular_Interacting_Partner_9_SNPs:
rs17289102; rs11861332; rs1064448; rs1872691; rs11644926; rs1540624; rs2302681; rs8052384; rs9939322; rs4785211; rs9936021; rs4785403; rs8061123; rs9926131; rs7191958; rs4785210; rs4785402; rs3813755; rs729229; rs2302712; rs11649380; rs9924714; rs8045659; rs8049122; rs2302680; rs7193839; rs11648839; rs7193875; rs2302717; rs2302715; rs12445243; rs11859417; rs728962; rs2302716; rs11861597; rs7202127; rs7186882; rs12444679; rs8056293; rs3833062; rs2302679; rs9927261; rs8060642; rs4082435; rs3826173; rs3892156; rs3760012; rs3760011; rs28514808; rs7359472; rs2230664; rs1064447; rs8051594; rs35787328; rs10589177; rs9940992; rs4785407; rs12918980; rs12444266; rs7500891; rs5816686; rs35969283; rs34860956; rs34493825; rs9937781; rs35262781; rs2302678; rs13332825; rs12932721; rs34996336; rs2302714; rs11640409; rs12932722; rs16948389; rs34039653; rs28510819; rs28432797; rs3841348; rs3214383; rs3815562; rs35078746; rs34191947; rs11403746; rs4502213; rs34381393; rs7197662; rs35284914; rs28403987; rs2302713; rs12919306; rs35003370; rs35732926; rs35829985; rs34216705; rs11352304; rs10577557; rs12444236; rs12924307; rs12598249; rs11417859; rs12443620; rs8048743; rs34009001; rs34686094; rs8053067; rs1078151; rs11644043; rs11645133; rs11649621; rs11860192; rs17216076; rs1872688; rs34176129; rs3760013; rs3760014; rs4497684; rs4785401; rs4785408; rs7184476; rs7184802; rs7196135; rs7204026; rs751127; rs8046783; rs8057103; rs8061808; rs9922362; rs9926720; rs9937029; rs9940619

# Macromolecular_Interacting_Partner_9_General_References:
7584026

# Macromolecular_Interacting_Partner_9_References:
16840977; 16943566; 17063155

# Macromolecular_Interacting_Partner_10_ID:
6979

# Macromolecular_Interacting_Partner_10_Name:
Somatostatin precursor

# Macromolecular_Interacting_Partner_10_Synonyms:
Growth hormone release-inhibiting factor[Contains: Somatostatin-28; Somatostatin-14]

# Macromolecular_Interacting_Partner_10_Gene_Name:
SST

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Somatostatin precursor
MLSCRLQCALAALSIVLALGCVTGAPSDPRLRQFLQKSLAAAAGKQELAKYFLAELLSEP
NQTENDALEPEDLSQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
116

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
12736

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
5.18

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
Somatostatin inhibits the release of somatotropin

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF03002:Somatostatin

# Macromolecular_Interacting_Partner_10_Signals:
1-24

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
338288

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
SMS_HUMAN (P61278)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
SST

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
SST

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:11329

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>351 bp
ATGCTGTCCTGCCGCCTCCAGTGCGCGCTGGCTGCGCTGTCCATCGTCCTGGCCCTGGGC
TGTGTCACCGGCGCTCCCTCGGACCCCAGACTCCGTCAGTTTCTGCAGAAGTCCCTGGCT
GCTGCCGCGGGGAAGCAGGAACTGGCCAAGTACTTCTTGGCAGAGCTGCTGTCTGAACCC
AACCAGACGGAGAATGATGCCCTGGAACCTGAAGATCTGTCCCAGGCTGCTGAGCAGGAT
GAAATGAGGCTTGAGCTGCAGAGATCTGCTAACTCAAACCCGGCTATGGCACCCCGAGAA
CGCAAAGCTGGCTGCAAGAATTTCTTCTGGAAGACTTTCACATCCTGTTAG

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
J00306

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_10_Locus:
3q28

# Macromolecular_Interacting_Partner_10_SNPs:
rs33934967; rs35603672; rs4988514; rs4988513; rs34477564; rs7624906; rs6797699; rs17796004; rs10513818; rs10513817; rs3755792; rs9822131; rs6784777; rs35435818; rs34907490; rs34148761; rs35648422; rs34026617; rs6784778; rs34714141; rs35517186; rs11544862; rs10576690; rs17796022; rs34988133; rs4988512; rs10704560; rs35410638; rs34872250; rs34488209; rs35880616; rs35564993; rs35405263; rs3834203; rs35293276; rs36047944; rs10513819; rs12495024; rs12635290; rs12636935; rs12638067; rs13434247; rs1365111; rs1365112; rs1365113; rs1425922; rs1425923; rs16862441; rs16862444; rs17728902; rs2114118; rs2114119; rs2162188; rs2162189; rs3864101; rs6786957; rs6789745; rs6794112; rs7626009; rs7631984; rs9290858; rs9810336; rs9842256; rs9842351; rs9842483; rs9852989; rs9865318; rs9872531

# Macromolecular_Interacting_Partner_10_General_References:
6126875; 6142531

# Macromolecular_Interacting_Partner_10_References:
17047391

# Macromolecular_Interacting_Partner_11_ID:
7739

# Macromolecular_Interacting_Partner_11_Name:
Protein phosphatase 1 regulatory subunit 1B

# Macromolecular_Interacting_Partner_11_Synonyms:
Dopamine- and cAMP- regulated neuronal phosphoprotein; DARPP-32

# Macromolecular_Interacting_Partner_11_Gene_Name:
PPP1R1B

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Protein phosphatase 1 regulatory subunit 1
BMDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASG
EGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPRE
EDEEEEEDDEEEEEEEDSQAEVLKVIRQSAGQKTTCGQGLEGPWERPPPLDESERDGGSE
DQVEDPALSEPGEEPQRPSPSEPGT

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
204

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
22963

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
4.18

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  phosphatase inhibitor activity
Function:  protein phosphatase inhibitor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_11_General_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Specific_Function:
Inhibitor of protein-phosphatase 1

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF05395:DARPP-32

# Macromolecular_Interacting_Partner_11_Signals:
None

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
21717548

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
PPR1B_HUMAN (Q9UD71)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
PPP1R1B

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
PPP1R1B

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:9287

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>615 bp
ATGGACCCCAAGGACCGCAAGAAGATCCAGTTCTCGGTGCCCGCGCCCCCTAGCCAGCTC
GACCCCCGCCAGGTGGAGATGATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGG
CTCTCAGAGCACTCCTCACCAGAGGAGGAAGCCTCCCCCCACCAGAGAGCCTCAGGAGAG
GGGCACCATCTCAAGTCGAAGAGACCCAACCCCTGTGCCTACACACCACCTTCGCTGAAA
GCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAG
GCCTCAGAGGAGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAA
GATGAGGAGGAAGAGGAGGATGATGAAGAAGAGGAAGAAGAAGAGGACAGCCAGGCTGAA
GTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAA
GGGCCCTGGGAGCGCCCACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCTCTGAGGAC
CAAGTGGAAGACCCAGCACTAAGTGAGCCTGGGGAGGAACCTCAGCGCCCTTCCCCCTCT
GAGCCTGGCACATAG

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
AF464196

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_11_Locus:
17q12

# Macromolecular_Interacting_Partner_11_SNPs:
rs2271309; rs33938012; rs33932099; rs907094; rs3764352; rs12601930; rs16965199; rs3751903; rs33978574; rs1495099; rs879606; rs10852934; rs4795390; rs9899653; rs35898202; rs34445181; rs34056202; rs35591311; rs34026896; rs3764353; rs392741; rs11869360; rs34848496; rs380503; rs35751045; rs11651497; rs451849; rs34773471; rs34963535; rs34719599; rs35163040; rs35998983; rs5820300; rs34433367; rs3029546; rs11651233; rs193359; rs3029545; rs35574838; rs3029547; rs9892853; rs12937003; rs1874224; rs1874225; rs1874228; rs2132140; rs2665646; rs33953566; rs34257414; rs35825115; rs3817160; rs4513130; rs7212852; rs734645; rs8066399; rs8075130; rs9532; rs9896679; rs9913626

# Macromolecular_Interacting_Partner_11_General_References:
8120638; 12124342; 10604473

# Macromolecular_Interacting_Partner_11_References:
16730373; 16750892; 16750903; 16781819

# Macromolecular_Interacting_Partner_12_ID:
7803

# Macromolecular_Interacting_Partner_12_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_12_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_12_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_12_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_12_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_12_Signals:
None

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_12_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_12_SNPs:
Not Available

# Macromolecular_Interacting_Partner_12_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_12_References:
16757732; 16949583; 17005263; 17015173

# Macromolecular_Interacting_Partner_13_ID:
8029

# Macromolecular_Interacting_Partner_13_Name:
D(4) dopamine receptor

# Macromolecular_Interacting_Partner_13_Synonyms:
Dopamine D4 receptor; D(2Cdopamine receptor

# Macromolecular_Interacting_Partner_13_Gene_Name:
DRD4

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>D4 dopamine receptor
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVA
TERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT
ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR
DPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG
PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPG
LPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAP
PDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALC
PACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
467

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
48361

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
8.37

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  amine receptor activity
Function:  dopamine receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_13_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_13_Specific_Function:
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_13_Signals:
None

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
38-60
71-93
110-131
152-175
192-213
395-417
427-449

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
291946

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
DRD4_HUMAN (P21917)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
DRD4

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
DRD4

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:3025

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>1404 bp
ATGGGGAACCGCAGCACCGCGGACGCGGACGGGCTGCTGGCTGGGCGCGGGCCGGCCGCG
GGGGCATCTGCGGGGGCATCTGCGGGGCTGGCTGGGCAGGGCGCGGCGGCGCTGGTGGGG
GGCGTGCTGCTCATCGGCGCGGTGCTCGCGGGGAACTCGCTCGTGTGCGTGAGCGTGGCC
ACCGAGCGCGCCCTGCAGACGCCCACCAACTCCTTCATCGTGAGCCTGGCGGCCGCCGAC
CTCCTCCTCGCTCTCCTGGTGCTGCCGCTCTTCGTCTACTCCGAGGTCCAGGGTGGCGCG
TGGCTGCTGAGCCCCCGCCTGTGCGACGCCCTCATGGCCATGGACGTCATGCTGTGCACC
GCCTCCATCTTCAACCTGTGCGCCATCAGCGTGGACAGGTTCGTGGCCGTGGCCGTGCCG
CTGCGCTACAACCGGCAGGGTGGGAGCCGCCGGCAGCTGCTGCTCATCGGCGCCACGTGG
CTGCTGTCCGCGGCGGTGGCGGCGCCCGTACTGTGCGGCCTCAACGACGTGCGCGGCCGC
GACCCCGCCGTGTGCCGCCTGGAGGACCGCGACTACGTGGTCTACTCGTCCGTGTGCTCC
TTCTTCCTACCCTGCCCGCTCATGCTGCTGCTCTACTGGGCCACGTTCCGCGGCCTGCAG
CGCTGGGAGGTGGCACGTCGCGCCAAGCTGCACGGCCGCGCGCCCCGCCGACCCAGCGGC
CCTGGCCCGCCTTCCCCCACGCCACCCGCGCCCCGCCTCCCCCAGGACCCCTGCGGCCCC
GACTGTGCGCCCCCCGCGCCCGGCCTTCCCCGGGGTCCCTGCGGCCCCGACTGTGCGCCC
GCCGCGCCCGGCCTCCCCCCGGACCCCTGCGGCCCCGACTGTGCGCCCCCCGCGCCCGGC
CTCCCCCAGGACCCCTGCGGCCCCGACTGTGCGCCCCCCGCGCCCGGCCTTCCCCGGGGT
CCCTGCGGCCCCGACTGTGCGCCCCCCGCGCCCGGCCTCCCCCAGGACCCCTGCGGCCCC
GACTGTGCGCCCCCCGCGCCCGGCCTCCCCCCGGACCCCTGCGGCTCCAACTGTGCTCCC
CCCGACGCCGTCAGAGCCGCCGCGCTCCCACCCCAGACTCCACCGCAGACCCGCAGGAGG
CGGCGTGCCAAGATCACCGGCCGGGAGCGCAAGGCCATGAGGGTCCTGCCGGTGGTGGTC
GGGGCCTTCCTGCTGTGCTGGACGCCCTTCTTCGTGGTGCACATCACGCAGGCGCTGTGT
CCTGCCTGCTCCGTGCCCCCGCGGCTGGTCAGCGCCGTCACCTGGCTGGGCTACGTCAAC
AGCGCCCTCAACCCCGTCATCTACACTGTCTTCAACGCCGAGTTCCGCAACGTCTTCCGC
AAGGCCCTGCGTGCCTGCTGCTGA

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
L12398

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_13_Locus:
11p15.5

# Macromolecular_Interacting_Partner_13_SNPs:
rs1800443; rs3889692; rs762502; rs752306; rs1870723; rs3832721; rs7124601; rs7482904; rs916456; rs747302; rs936461; rs3758653; rs916457; rs936462; rs11246226; rs11607201; rs4987059; rs4986926; rs3842250; rs4987058; rs916455; rs1800955; rs10902180; rs936460; rs11246223; rs747303; rs4991149; rs4991150; rs34662058; rs12720386; rs4991151; rs12720410; rs936463; rs34773603; rs4991148; rs12720394; rs12720391; rs12720389; rs12720407; rs12720387; rs12720395; rs12720402; rs12720404; rs12720398; rs4497440; rs12720393; rs12720413; rs12720388; rs12720408; rs12720401; rs5789203; rs12720392; rs12720406; rs12720399; rs12720397; rs12720403; rs35810291; rs12720390; rs12720396; rs12720409; rs12720400; rs12720412; rs12720411; rs12720371; rs41298422; rs12720423; rs12720414; rs12720418; rs12720369; rs11246222; rs11246225; rs12720373; rs35383378; rs12720367; rs12720364; rs12720416; rs12720381; rs12720422; rs12720384; rs12720421; rs12720377; rs12720419; rs28702058; rs12720382; rs12720368; rs12720366; rs12720417; rs12720424; rs12720415; rs12720385; rs12788170; rs12720380; rs12720420; rs11246224; rs12720376; rs2396543; rs12720372; rs12720383; rs12720379; rs12720365; rs11606707; rs12720370; rs11246227; rs11246228; rs11604855; rs11604859; rs17758; rs1802261; rs34114147; rs4331145; rs7116517; rs7125390; rs7933153; rs936464; rs936465

# Macromolecular_Interacting_Partner_13_General_References:
1319557; 1840645; 1358063; 7726213

# Macromolecular_Interacting_Partner_13_References:
16774975; 16816977

# Macromolecular_Interacting_Partner_14_ID:
8159

# Macromolecular_Interacting_Partner_14_Name:
5-hydroxytryptamine 2A receptor

# Macromolecular_Interacting_Partner_14_Synonyms:
5-HT-2A; Serotonin receptor 2A; 5- HT-2

# Macromolecular_Interacting_Partner_14_Gene_Name:
HTR2A

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>5hydroxytryptamine 2A receptor
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
471

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
52604

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
7.72

# Macromolecular_Interacting_Partner_14_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_14_General_Function:
Not Available

# Macromolecular_Interacting_Partner_14_Specific_Function:
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production

# Macromolecular_Interacting_Partner_14_Pathway:
Not Available

# Macromolecular_Interacting_Partner_14_Reaction:
Not Available

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_14_Signals:
None

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
76-99
111-132
148-171
192-215
234-254
325-346
363-384

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
36431

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
5HT2A_HUMAN (P28223)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
HTR2A

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
HTR2A

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:5293

# Macromolecular_Interacting_Partner_14_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Cell membrane; multi-pass membrane protein. Note=Localizes to the post-synaptic thickening of axo-dendritic synapses (By similarity)

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>1416 bp
ATGGATATTCTTTGTGAAGAAAATACTTCTTTGAGCTCAACTACGAACTCCCTAATGCAA
TTAAATGATGACACCAGGCTCTACAGTAATGACTTTAACTCTGGAGAAGCTAACACTTCT
GATGCATTTAACTGGACAGTCGACTCTGAAAATCGAACCAACCTTTCCTGTGAAGGGTGC
CTCTCACCGTCGTGTCTCTCCTTACTTCATCTCCAGGAAAAAAACTGGTCTGCTTTACTG
ACAGCCGTAGTGATTATTCTAACTATTGCTGGAAACATACTCGTCATCATGGCAGTGTCC
CTAGAGAAAAAGCTGCAGAATGCCACCAACTATTTCCTGATGTCACTTGCCATAGCTGAT
ATGCTGCTGGGTTTCCTTGTCATGCCCGTGTCCATGTTAACCATCCTGTATGGGTACCGG
TGGCCTCTGCCGAGCAAGCTTTGTGCAGTCTGGATTTACCTGGACGTGCTCTTCTCCACG
GCCTCCATCATGCACCTCTGCGCCATCTCGCTGGACCGCTACGTCGCCATCCAGAATCCC
ATCCACCACAGCCGCTTCAACTCCAGAACTAAGGCATTTCTGAAAATCATTGCTGTTTGG
ACCATATCAGTAGGTATATCCATGCCAATACCAGTCTTTGGGCTACAGGACGATTCGAAG
GTCTTTAAGGAGGGGAGTTGCTTACTCGCCGATGATAACTTTGTCCTGATCGGCTCTTTT
GTGTCATTTTTCATTCCCTTAACCATCATGGTGATCACCTACTTTCTAACTATCAAGTCA
CTCCAGAAAGAAGCTACTTTGTGTGTAAGTGATCTTGGCACACGGGCCAAATTAGCTTCT
TTCAGCTTCCTCCCTCAGAGTTCTTTGTCTTCAGAAAAGCTCTTCCAGCGGTCGATCCAT
AGGGAGCCAGGGTCCTACACAGGCAGGAGGACTATGCAGTCCATCAGCAATGAGCAAAAG
GCATGCAAGGTGCTGGGCATCGTCTTCTTCCTGTTTGTGGTGATGTGGTGCCCTTTCTTC
ATCACAAACATCATGGCCGTCATCTGCAAAGAGTCCTGCAATGAGGATGTCATTGGGGCC
CTGCTCAATGTGTTTGTTTGGATCGGTTATCTCTCTTCAGCAGTCAACCCACTAGTCTAC
ACACTGTTCAACAAGACCTATAGGTCAGCCTTTTCACGGTATATTCAGTGTCAGTACAAG
GAAAACAAAAAACCATTGCAGTTAATTTTAGTGAACACAATACCGGCTTTGGCCTACAAG
TCTAGCCAACTTCAAATGGGACAAAAAAAGAATTCAAAGCAAGATGCCAAGACAACAGAT
AATGACTGCTCAATGGTTGCTCTAGGAAAGCAGCATTCTGAAGAGGCTTCTAAAGACAAT
AGCGACGGAGTGAATGAAAAGGTGAGCTGTGTGTGA

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
X57830

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:13

# Macromolecular_Interacting_Partner_14_Locus:
13q14-q21

# Macromolecular_Interacting_Partner_14_SNPs:
rs1805055; rs6304; rs6308; rs6314; rs6313; rs6305; rs35480504; rs3803189; rs3125; rs17069218; rs2296973; rs1923888; rs1745837; rs643627; rs2770295; rs1002513; rs1923882; rs1923884; rs1928038; rs977003; rs1928040; rs633737; rs2770298; rs1885884; rs1923887; rs2760351; rs4942578; rs9534506; rs1928042; rs4941574; rs6561334; rs1033847; rs985934; rs9567739; rs4942587; rs2070036; rs9534511; rs2070039; rs9534493; rs9316232; rs927544; rs6561336; rs4941571; rs594242; rs9567737; rs985933; rs9534507; rs582385; rs659734; rs972979; rs4941573; rs7322347; rs582854; rs7324343; rs6561335; rs2274639; rs731779; rs9567735; rs9534509; rs2770300; rs4942582; rs17069089; rs2025296; rs2246127; rs9526238; rs1928041; rs11841433; rs622337; rs9534505; rs4941570; rs9316235; rs2070040; rs7330636; rs1328684; rs12584920; rs9526240; rs1923885; rs666693; rs2770296; rs4942583; rs7984966; rs2070037; rs9562686; rs655888; rs6561332; rs655854; rs2770302; rs9567746; rs1328683; rs7330461; rs9526246; rs1923886; rs17288723; rs2770293; rs9316233; rs2296972; rs1928039; rs9526245; rs2770304; rs2770297; rs7994746; rs1328674; rs632903; rs1410657; rs3742279; rs2224721; rs2770294; rs621494; rs912127; rs9534495; rs17359763; rs12876614; rs2760346; rs7322422; rs9567744; rs2770299; rs9534502; rs9526241; rs7332753; rs17287961; rs9526239; rs9567743; rs3945573; rs2760344; rs2760349; rs658101; rs17068986; rs7322420; rs7326071; rs7986766; rs9562687; rs731778; rs9316236; rs689099; rs677702; rs11617142; rs2760345; rs4942584; rs17360184; rs2016711; rs2760350; rs619549; rs1885882; rs9567747; rs1328677; rs7981633; rs2770292; rs1328675; rs17069020; rs3742278; rs7328886; rs7997012; rs4942585; rs2760348; rs9534496; rs1928043; rs7323792; rs9562689; rs7338257; rs9534503; rs17069035; rs9534508; rs9567745; rs7330368; rs9567736; rs4090088; rs9562685; rs17069005; rs9534510; rs9316234; rs2070035; rs9670454; rs9534504; rs9534501; rs9562688; rs2760347; rs7323079; rs7985321; rs1475196; rs1328685; rs6312; rs7324218; rs6310; rs6316; rs6311; rs7325168; rs17289304; rs7324017; rs7323441; rs7325200; rs7997977; rs7996679; rs7325801; rs7323693; rs6315; rs7324942; rs6306; rs6309; rs6317; rs9595552; rs2230948; rs6307; rs1058576; rs35224115; rs1058573; rs35942462; rs34073547; rs28461499; rs34600609; rs35222525; rs11619524; rs9562684; rs34067369; rs34546983; rs34735457; rs34191502; rs35044667; rs5803378; rs34023544; rs34389615; rs1923883; rs11444567; rs1885883; rs34156927; rs35600514; rs7317640; rs4942586; rs34265171; rs28439202; rs9567748; rs36032976; rs7322128; rs34450267; rs35735410; rs41306666; rs4942579; rs5803377; rs2770301; rs34116107; rs9534497; rs34758371; rs9567734; rs2760340; rs2146672; rs4942580; rs11148017; rs2405864; rs9567742; rs2183056; rs35774769; rs1923889; rs2770303; rs9526237; rs35990864; rs4941572; rs35157208; rs9567740; rs660358; rs2760339; rs9567738; rs33974073; rs2760343; rs11394720; rs34188313; rs2760342; rs7491120; rs35031636; rs7490923; rs17069045; rs35265991; rs2405863; rs11381663; rs10666389; rs35136640; rs12862862; rs34420017; rs10675250; rs1328676; rs688590; rs626318; rs4536360; rs10562734; rs9595553; rs35906144; rs10648117; rs34493167; rs2070038; rs5803379; rs41284193; rs2760341; rs7992607; rs35166479; rs35805696; rs33913126; rs35656598; rs1125644; rs13306426; rs36212791; rs1125643; rs36212451; rs36212784; rs36212792; rs35865007; rs36212789; rs36213156; rs1048952; rs34720476; rs10507544; rs12017281; rs12863574; rs17069137; rs17289394; rs2149433; rs2149434; rs4142900; rs4286023; rs4387507; rs4389056; rs4389057; rs4389058; rs4575433; rs4941575; rs4942588; rs6561333; rs731244; rs731245; rs732821; rs7328833; rs7329640; rs7330190; rs7330205; rs7333412; rs7490304; rs9534490; rs9534491; rs9534512; rs9534513; rs9534514; rs9534515; rs9567731; rs9567732; rs9567733; rs9590997; rs9595546; rs9595549; rs9595550; rs9595551

# Macromolecular_Interacting_Partner_14_General_References:
1722404; 1323014; 8035173; 1330647; 11150294; 8655141; 10581480; 10391209

# Macromolecular_Interacting_Partner_14_References:
16871540; 17005723; 17065978

# Macromolecular_Interacting_Partner_15_ID:
7947

# Macromolecular_Interacting_Partner_15_Name:
Neurotensin/neuromedin N precursor [Contains: Large neuromedin N

# Macromolecular_Interacting_Partner_15_Synonyms:
NmN- 125; Neuromedin N; NmN; NN; Neurotensin; NT; Tail peptide]

# Macromolecular_Interacting_Partner_15_Gene_Name:
NTS

# Macromolecular_Interacting_Partner_15_Protein_Sequence:
>Neurotensin/neuromedin N precursor Contains: Large neuromedin 
NMMAGMKIQLVCMLLLAFSSWSLCSDSEEEMKALEADFLTNMHTSKISKAHVPSWKMTLL
NVCSLVNNLNSPAEETGEVHEEELVARRKLPTALDGFSLEAMLTIYQLHKICHSRAFQHW
ELIQEDILDTGNDKNGKEEVIKRKIPYILKRQLYENKPRRPYILKRDSYYY

# Macromolecular_Interacting_Partner_15_Number_of_Residues:
170

# Macromolecular_Interacting_Partner_15_Molecular_Weight:
19795

# Macromolecular_Interacting_Partner_15_Theoretical_pI:
7.11

# Macromolecular_Interacting_Partner_15_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
Function:  neuropeptide hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_15_General_Function:
Not Available

# Macromolecular_Interacting_Partner_15_Specific_Function:
Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle

# Macromolecular_Interacting_Partner_15_Pathway:
Not Available

# Macromolecular_Interacting_Partner_15_Reaction:
Not Available

# Macromolecular_Interacting_Partner_15_Pfam_Domain_Function:
PF07421:Pro-NT_NN

# Macromolecular_Interacting_Partner_15_Signals:
1-23

# Macromolecular_Interacting_Partner_15_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_15_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_15_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_15_GenBank_ID_Protein:
1907393

# Macromolecular_Interacting_Partner_15_SwissProt_ID:
NEUT_HUMAN (P30990)

# Macromolecular_Interacting_Partner_15_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_15_Genecard_id:
NTS

# Macromolecular_Interacting_Partner_15_Geneatlas_id:
NTS

# Macromolecular_Interacting_Partner_15_hgnc_id:
HGNC:8038

# Macromolecular_Interacting_Partner_15_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_15_Subcellular_Location:
Secreted protein. Cytoplasmic vesicle; secretory vesicle. Note=Packaged within secretory vesicles

# Macromolecular_Interacting_Partner_15_Gene_Sequence:
>513 bp
ATGATGGCAGGAATGAAAATCCAGCTTGTATGCATGCTACTCCTGGCTTTCAGCTCCTGG
AGTCTGTGCTCAGATTCAGAAGAGGAAATGAAAGCATTAGAAGCAGATTTCTTGACCAAT
ATGCATACATCAAAGATTAGTAAAGCACATGTTCCCTCTTGGAAGATGACTCTGCTAAAT
GTTTGCAGTCTTGTAAATAATTTGAACAGCCCAGCTGAGGAAACAGGAGAAGTTCATGAA
GAGGAGCTTGTTGCAAGAAGGAAACTTCCTACTGCTTTAGATGGCTTTAGCTTGGAAGCA
ATGTTGACAATATACCAGCTCCACAAAATCTGTCACAGCAGGGCTTTTCAACACTGGGAG
TTAATCCAGGAAGATATTCTTGATACTGGAAATGACAAAAATGGAAAGGAAGAAGTCATA
AAGAGAAAAATTCCTTATATTCTGAAACGGCAGCTGTATGAGAATAAACCCAGAAGACCC
TACATACTCAAAAGAGATTCTTACTATTACTGA

# Macromolecular_Interacting_Partner_15_GenBank_ID_Gene:
U91618

# Macromolecular_Interacting_Partner_15_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_15_Locus:
12q21

# Macromolecular_Interacting_Partner_15_SNPs:
rs11117072; rs17013451; rs12313658; rs11615953; rs10863088; rs10735487; rs5020966; rs12311338; rs12312795; rs3764040; rs11117074; rs2234762; rs3764039; rs1050926; rs1800832; rs34661721; rs28406972; rs4608174; rs34324813; rs28477441; rs11117068; rs34134618; rs5020968; rs12296858; rs34399829; rs12830688; rs11117071; rs11117070; rs12304244; rs5799760; rs10863087; rs35124959; rs11117069; rs34429786; rs11117067; rs12306364; rs11117066; rs5020967; rs11117075; rs12318859; rs11117073; rs11117076; rs12228233; rs10863089; rs10863090; rs10863091; rs10863093; rs11117064; rs11117078; rs11117079; rs11117081; rs11117083; rs11117086; rs1123924; rs11615323; rs11836655; rs12299571; rs12299615; rs1349063; rs34615498; rs7131688; rs7132746; rs7133309; rs7298173; rs7315084; rs7965388; rs930638

# Macromolecular_Interacting_Partner_15_General_References:
9530155; 1436492

# Macromolecular_Interacting_Partner_15_References:
17116165

# Macromolecular_Interacting_Partner_16_ID:
7879

# Macromolecular_Interacting_Partner_16_Name:
Alpha-synuclein

# Macromolecular_Interacting_Partner_16_Synonyms:
Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP

# Macromolecular_Interacting_Partner_16_Gene_Name:
SNCA

# Macromolecular_Interacting_Partner_16_Protein_Sequence:
>Alphasynuclein
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK
EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP
DNEAYEMPSEEGYQDYEPEA

# Macromolecular_Interacting_Partner_16_Number_of_Residues:
140

# Macromolecular_Interacting_Partner_16_Molecular_Weight:
14460

# Macromolecular_Interacting_Partner_16_Theoretical_pI:
4.37

# Macromolecular_Interacting_Partner_16_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_16_General_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Specific_Function:
May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule- associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation

# Macromolecular_Interacting_Partner_16_Pathway:
Not Available

# Macromolecular_Interacting_Partner_16_Reaction:
Not Available

# Macromolecular_Interacting_Partner_16_Pfam_Domain_Function:
PF01387:Synuclein

# Macromolecular_Interacting_Partner_16_Signals:
None

# Macromolecular_Interacting_Partner_16_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_16_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_16_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_16_GenBank_ID_Protein:
437365

# Macromolecular_Interacting_Partner_16_SwissProt_ID:
SYUA_HUMAN (P37840)

# Macromolecular_Interacting_Partner_16_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_16_Genecard_id:
SNCA

# Macromolecular_Interacting_Partner_16_Geneatlas_id:
SNCA

# Macromolecular_Interacting_Partner_16_hgnc_id:
HGNC:11138

# Macromolecular_Interacting_Partner_16_PDB_ID:
1XQ8

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_16_Subcellular_Location:
Cytoplasm. Membrane. Nucleus. Note=Membrane- bound in dopaminergic neurons. Also found in the nucleus

# Macromolecular_Interacting_Partner_16_Gene_Sequence:
>423 bp
ATGGATGTATTCATGAAAGGACTTTCAAAGGCCAAGGAGGGAGTTGTGGCTGCTGCTGAG
AAAACCAAACAGGGTGTGGCAGAAGCAGCAGGAAAGACAAAAGAGGGTGTTCTCTATGTA
GGCTCCAAAACCAAGGAGGGAGTGGTGCATGGTGTGGCAACAGTGGCTGAGAAGACCAAA
GAGCAAGTGACAAATGTTGGAGGAGCAGTGGTGACGGGTGTGACAGCAGTAGCCCAGAAG
ACAGTGGAGGGAGCAGGGAGCATTGCAGCAGCCACTGGCTTTGTCAAAAAGGACCAGTTG
GGCAAGAATGAAGAAGGAGCCCCACAGGAAGGAATTCTGGAAGATATGCCTGTGGATCCT
GACAATGAGGCTTATGAAATGCCTTCTGAGGAAGGGTATCAAGACTACGAACCTGAAGCC
TAA

# Macromolecular_Interacting_Partner_16_GenBank_ID_Gene:
L08850

# Macromolecular_Interacting_Partner_16_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_16_Locus:
4q21

# Macromolecular_Interacting_Partner_16_SNPs:
rs356165; rs17016074; rs35101723; rs2583968; rs356184; rs748849; rs2737020; rs356191; rs2737029; rs356188; rs2736999; rs2736990; rs1812923; rs356162; rs2119787; rs2737001; rs1442148; rs2583975; rs2583978; rs972880; rs2737021; rs1811442; rs1442145; rs2197120; rs2583972; rs356195; rs356163; rs2298728; rs356196; rs2737030; rs4031753; rs2619353; rs2583959; rs1442147; rs7356297; rs3756054; rs10033209; rs6811479; rs3775434; rs2737025; rs6826785; rs6828271; rs1471484; rs2737009; rs894278; rs2737019; rs2737023; rs2619341; rs2572324; rs2619348; rs3857060; rs3113355; rs1811443; rs2737006; rs1471483; rs2619372; rs356198; rs2619350; rs2583969; rs6848726; rs974711; rs3775443; rs2583984; rs3775423; rs356189; rs11097238; rs7655611; rs2619355; rs356203; rs1442146; rs3796665; rs2737008; rs356164; rs6532191; rs3910105; rs7684318; rs3775438; rs3775433; rs3857061; rs7690873; rs2737022; rs3906824; rs11097234; rs920624; rs3775448; rs3796661; rs356199; rs1866995; rs3756057; rs7356228; rs1837890; rs6842093; rs2737013; rs2619371; rs2583983; rs10155475; rs356187; rs2737024; rs12502363; rs2737033; rs6532190; rs3775439; rs11944331; rs2737028; rs961386; rs10005233; rs3899608; rs3857059; rs3822090; rs356168; rs3822095; rs2737015; rs2583964; rs17180453; rs2619368; rs3857058; rs3775442; rs7698672; rs3775447; rs3775422; rs12648141; rs10516847; rs33965306; rs10008964; rs4293762; rs356185; rs356200; rs2737000; rs6834765; rs17016168; rs17016080; rs3822089; rs17016251; rs17016193; rs4088093; rs7686472; rs7684892; rs3756056; rs3775461; rs17016196; rs3910104; rs2583977; rs356201; rs28393675; rs33978842; rs356193; rs17016255; rs356167; rs3822091; rs3796662; rs7661330; rs17016107; rs2583958; rs34351491; rs4088094; rs6820267; rs10516845; rs3822088; rs3831458; rs13142587; rs2583971; rs17016124; rs986609; rs3775450; rs3775435; rs3729594; rs3898322; rs3756055; rs1442143; rs356166; rs2737014; rs2298727; rs3822086; rs2737005; rs11931062; rs10433953; rs6419125; rs990085; rs744391; rs2572318; rs2583963; rs3796667; rs3889917; rs356202; rs3775424; rs3216147; rs17016126; rs3775446; rs2619347; rs11935469; rs356204; rs3775437; rs2737032; rs2619358; rs17016083; rs2736998; rs3889916; rs2583979; rs35300122; rs3775427; rs3775429; rs1442144; rs10023587; rs2583980; rs17016235; rs2737004; rs2737002; rs35409299; rs2619343; rs10516846; rs35541731; rs34356244; rs3775430; rs35789154; rs3836645; rs17016188; rs35232645; rs744392; rs34417114; rs35646314; rs11944927; rs986610; rs1837891; rs34752070; rs2583966; rs356205; rs34674090; rs35214126; rs34094566; rs17016237; rs1837888; rs168550; rs34840261; rs35272004; rs6829514; rs3775444; rs35016354; rs2583976; rs2619344; rs11933323; rs35029783; rs10014396; rs34449021; rs3841995; rs10002435; rs2583960; rs17795442; rs2737012; rs1442149; rs35771728; rs17016127; rs35257174; rs34332571; rs34194714; rs34262102; rs35850745; rs9995651; rs356186; rs12509498; rs2583967; rs2583962; rs2619342; rs17016190; rs9762836; rs17016174; rs3857057; rs2583973; rs17016183; rs35426485; rs34820701; rs34634504; rs34414536; rs36113443; rs35432630; rs36014224; rs2619357; rs17180628; rs34631133; rs34238791; rs35572077; rs2583981; rs34183114; rs35761327; rs2619354; rs7684637; rs2583970; rs189596; rs2619356; rs17016100; rs35540244; rs34638560; rs2619369; rs34780681; rs34369946; rs7689942; rs35148678; rs36045134; rs34342799; rs17795208; rs34806123; rs34320254; rs3857054; rs34699553; rs34567193; rs35479630; rs35897584; rs35280079; rs34411652; rs1837889; rs35965605; rs11731474; rs2619349; rs35921673; rs35495602; rs356192; rs17016259; rs3841996; rs34747217; rs2583974; rs34237954; rs34934143; rs35708121; rs35683433; rs35236343; rs35332963; rs2583965; rs35683448; rs36089697; rs34410265; rs34426119; rs3836642; rs3775426; rs34164595; rs34611148; rs34683772; rs184810; rs3796664; rs356194; rs2619373; rs34735368; rs35343127; rs34104455; rs2736991; rs35943576; rs2737011; rs34506386; rs35267877; rs2619345; rs3857053; rs1045722; rs7675290; rs17016072; rs35808877; rs7675105; rs10024743; rs35343095; rs34825021; rs35716318; rs35733299; rs35212814; rs35933045; rs1372514; rs2736997; rs35201670; rs3836640; rs3054980; rs35986865; rs35989533; rs34687600; rs35526033; rs12508487; rs3822087; rs28489158; rs35748691; rs35141042; rs11329703; rs11935449; rs35911144; rs35231548; rs36221043; rs34947034; rs35871105; rs35569817; rs33958986; rs35120797; rs35291242; rs3822092; rs3775458; rs10002059; rs11304435; rs34303827; rs34724715; rs35122147; rs35343552; rs13129749; rs35016217; rs35001620; rs35142806; rs35360793; rs35602429; rs2737017; rs730903; rs33957677; rs34765555; rs35032813; rs28485757; rs10545575; rs35503287; rs3055022; rs34334080; rs34953765; rs2583982; rs34840078; rs35161435; rs35957456; rs28536191; rs11303281; rs34991691; rs13119175; rs35659443; rs35720278; rs35818392; rs2572319; rs10674833; rs34326258; rs34121241; rs7665887; rs35214759; rs35047774; rs7439510; rs3775432; rs35798275; rs35609638; rs35360521; rs17795575; rs36050102; rs35507606; rs34249189; rs35936625; rs34434291; rs36056834; rs28478339; rs2619351; rs2882784; rs10002682; rs35440318; rs34634221; rs34930175; rs3857055; rs34930588; rs6814683; rs34309515; rs36019133; rs35277735; rs34116004; rs35094640; rs34830357; rs11310372; rs2572320; rs35045207; rs33978881; rs2736992; rs35546605; rs34084430; rs34147017; rs34501446; rs356190; rs10018362; rs34068531; rs3775445; rs5860182; rs2737010; rs34514896; rs34862283; rs2619370; rs9917874; rs35038172; rs10659555; rs3836643; rs13135728; rs2619359; rs11366429; rs11371844; rs13119625; rs34973916; rs2619346; rs35925403; rs35989404; rs3054966; rs33945275; rs34385672; rs10603167; rs34391572; rs7674012; rs13146392; rs10683663; rs13119392; rs3775455; rs34530979; rs35953562; rs35428518; rs7699596; rs11335922; rs28444839; rs35799475; rs35270074; rs34847694; rs35258498; rs28720123; rs35832524; rs36026759; rs3775453; rs34311864; rs34441859; rs12505201; rs34304288; rs10013876; rs3775436; rs28453931; rs13127116; rs34994037; rs35932998; rs11097231; rs6857591; rs10003244; rs35112666; rs35097568; rs6830383; rs35502643; rs35770406; rs34769416; rs3891864; rs2737003; rs34770944; rs3857056; rs35000188; rs17180785; rs4031752; rs34306785; rs6825073; rs3775431; rs13119409; rs34422961; rs17016129; rs35182462; rs13119570; rs3836644; rs34105552; rs13146370; rs2736996; rs3836639; rs3836641; rs13101988; rs11734377; rs33978377; rs7674771; rs35543155; rs35643053; rs35232376; rs35703992; rs35807421; rs35147460; rs35208544; rs356197; rs10034964; rs34928594; rs7356233; rs36119871; rs4629405; rs10614384; rs28489315; rs4635786; rs11317534; rs34049266; rs35333163; rs13128806; rs35912572; rs35522252; rs10025915; rs34460217; rs34701768; rs10614008; rs28412513; rs2882785; rs2619352; rs33927204; rs34243759; rs35133234; rs2737007; rs34211144; rs2737016; rs28613708; rs35950841; rs34344142; rs35715972; rs7438200; rs35655405; rs13146583; rs34422187; rs34527974; rs35899759; rs28755455; rs6843700; rs13119195; rs34785663; rs10002163; rs34432250; rs11347916; rs35510249; rs11301332; rs35309192; rs35064322; rs12647731; rs35283133; rs34239605; rs5860181; rs34083286; rs28781297; rs11362345; rs12512480; rs723368; rs33960466; rs2737018; rs34240519; rs34143751; rs13146401; rs34395232; rs744522; rs10009268; rs34495265; rs35654679; rs34194811; rs34258126; rs34305140; rs11388660; rs34821270; rs35380906; rs35034159; rs34200659; rs35414462; rs34016975; rs3775440; rs35945367; rs35410547; rs34511254; rs10024463; rs13146813; rs36124975; rs17795424; rs35595109; rs35648044; rs3055032; rs6830166; rs10669463; rs33947180; rs34177337; rs13107108; rs34316582; rs34012637; rs3796663; rs33928931; rs34132221; rs33983294; rs11097235; rs13146571; rs35290339; rs35270750; rs34094651; rs33988309; rs5860180; rs34094043; rs1987877; rs10003708; rs10009760; rs1023777; rs10516844; rs11931074; rs11944336; rs11946721; rs12233696; rs13102582; rs1372516; rs1372517; rs1372518; rs1372519; rs1372520; rs1372521; rs1372522; rs168552; rs17016071; rs17016274; rs1822217; rs2028535; rs2035268; rs2245801; rs2301134; rs2301135; rs2583985; rs2583987; rs2583988; rs2619360; rs2619361; rs2619363; rs2619364; rs2619365; rs2619366; rs2619367; rs2736995; rs2870027; rs2870028; rs356216; rs356217; rs356218; rs356219; rs356220; rs356221; rs356222; rs356225; rs356226; rs3756059; rs3756063; rs3857051; rs3857052; rs3906694; rs6817001; rs6817026; rs6843084; rs7436973; rs7655792; rs7672979; rs7680557; rs7680761; rs7681312; rs7681440; rs7681815; rs7687945; rs7693001; rs7697570; rs8180209; rs8180214; rs9307075; rs990086; rs990087; rs990088; rs994589

# Macromolecular_Interacting_Partner_16_General_References:
8248242; 7601450; 7802671; 10617630; 10852916; 11821392; 12859192; 12859200; 12558071; 9197268; 9462735

# Macromolecular_Interacting_Partner_16_References:
16791599; 16957086; 16981894; 17131421

# Macromolecular_Interacting_Partner_17_ID:
8046

# Macromolecular_Interacting_Partner_17_Name:
Sodium-dependent dopamine transporter

# Macromolecular_Interacting_Partner_17_Synonyms:
DA transporter; DAT

# Macromolecular_Interacting_Partner_17_Gene_Name:
SLC6A3

# Macromolecular_Interacting_Partner_17_Protein_Sequence:
>Sodiumdependent dopamine transporter
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV

# Macromolecular_Interacting_Partner_17_Number_of_Residues:
620

# Macromolecular_Interacting_Partner_17_Molecular_Weight:
68496

# Macromolecular_Interacting_Partner_17_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_17_GO_Classification:
>>>
Function:  transporter activity
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
Function:  dopamine:sodium symporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_17_General_Function:
Not Available

# Macromolecular_Interacting_Partner_17_Specific_Function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals

# Macromolecular_Interacting_Partner_17_Pathway:
Not Available

# Macromolecular_Interacting_Partner_17_Reaction:
Not Available

# Macromolecular_Interacting_Partner_17_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_17_Signals:
None

# Macromolecular_Interacting_Partner_17_Transmembrane_Regions:
69-89
96-116
140-160
238-256
265-282
318-335
347-368
401-420
447-465
481-501
522-541
560-578

# Macromolecular_Interacting_Partner_17_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_17_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_17_GenBank_ID_Protein:
553260

# Macromolecular_Interacting_Partner_17_SwissProt_ID:
SC6A3_HUMAN (Q01959)

# Macromolecular_Interacting_Partner_17_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_17_Genecard_id:
SLC6A3

# Macromolecular_Interacting_Partner_17_Geneatlas_id:
SLC6A3

# Macromolecular_Interacting_Partner_17_hgnc_id:
HGNC:11049

# Macromolecular_Interacting_Partner_17_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_17_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_17_Gene_Sequence:
>278 bp
GCTGCACTATCTCTTCTCCTCCTTCACCACGGAGCTCCCCTGGATCCACTGCAACAACTC
CTGGAACAGCCCCAACTGCTCGGATGCCCATCCTGGTGACTCCAGTGGAGACAGCTCGGG
CCTCAACGACACTTTTGGGACCACACCTGCTGCCGAGTACTTTGAACGTGGCGTGCTGCA
CCTCCACCAGAGCCATGGCATCGACGACCTGGGGCCTCCGCGGTGGCAGCTCACAGCCTG
CCTGGTGCTGGTCATCGTGCTGCTCTACTTCAGCCTCT

# Macromolecular_Interacting_Partner_17_GenBank_ID_Gene:
M96670

# Macromolecular_Interacting_Partner_17_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_17_Locus:
5p15.3

# Macromolecular_Interacting_Partner_17_SNPs:
rs2270912; rs6349; rs8179034; rs6347; rs6880875; rs8179035; rs28363072; rs6348; rs27072; rs1042098; rs403798; rs3797200; rs7732456; rs1809939; rs11564774; rs16877691; rs28363170; rs28363174; rs1042128; rs28363166; rs9312841; rs6876890; rs28363168; rs9312842; rs2975284; rs461753; rs460700; rs463379; rs27047; rs456082; rs37021; rs461677; rs458334; rs37022; rs2963253; rs10072058; rs11133767; rs40184; rs2975292; rs11737901; rs6869645; rs10052985; rs2617577; rs460000; rs459141; rs410209; rs2042449; rs456774; rs462523; rs458609; rs464049; rs3776512; rs3834250; rs250686; rs11564759; rs11564762; rs460007; rs462053; rs4975646; rs11564767; rs8179031; rs427284; rs465130; rs16878300; rs10053602; rs11564758; rs2617605; rs8179029; rs3776511; rs11564771; rs2550936; rs10155607; rs6876225; rs487781; rs37020; rs429699; rs536616; rs365663; rs246997; rs10052016; rs11133778; rs2245660; rs11564764; rs464061; rs393795; rs466630; rs10040882; rs3776513; rs11133768; rs457894; rs465989; rs409588; rs10074171; rs11564769; rs403636; rs420422; rs27048; rs458632; rs3756451; rs250682; rs28363080; rs28382230; rs11564766; rs28363151; rs28363098; rs2927675; rs456645; rs28363074; rs428280; rs11564763; rs28363085; rs10475006; rs28363160; rs28382252; rs410481; rs28363155; rs2963252; rs11564773; rs28363124; rs28363114; rs28382247; rs2963239; rs28363141; rs28382245; rs28363119; rs2735917; rs2911492; rs2927676; rs2963242; rs28363090; rs250681; rs28363152; rs28363142; rs4975547; rs460934; rs11133770; rs11951672; rs28363115; rs28363120; rs2975291; rs4975641; rs458860; rs28363161; rs28363156; rs28382246; rs28382248; rs28363086; rs40358; rs28363101; rs28363138; rs28382251; rs3842031; rs28363106; rs1048955; rs28363129; rs28363125; rs11953287; rs2937643; rs3776514; rs28382228; rs28363083; rs6886753; rs28363153; rs11564768; rs11564761; rs28363111; rs2173947; rs28363116; rs2927677; rs28363149; rs28363154; rs28363139; rs457702; rs28363109; rs28363126; rs28363157; rs28363159; rs28363133; rs28382242; rs28742608; rs28363077; rs28382254; rs250684; rs28382237; rs28363079; rs28363089; rs28382244; rs28363082; rs10068876; rs10051340; rs1048953; rs378607; rs11564772; rs28382257; rs28382234; rs2652514; rs28363117; rs3056480; rs13169612; rs250683; rs11564765; rs13161905; rs28363104; rs4975638; rs2975293; rs28363078; rs28363092; rs10036478; rs28363099; rs28363076; rs2963241; rs28363113; rs10064525; rs11133762; rs2617596; rs6413429; rs12516948; rs11564751; rs2652511; rs6866570; rs28363179; rs28363178; rs3863145; rs28363185; rs28363181; rs28363177; rs6345; rs28364997; rs28364996; rs35337610; rs28364998; rs28363169; rs1042130; rs28363171; rs41282613; rs28363172; rs28363175; rs426305; rs1042125; rs11564775; rs1042132; rs1042129; rs2652504; rs28363167; rs41280377; rs28363173; rs34377601; rs2735933; rs28363069; rs11738968; rs34840629; rs2735910; rs28656867; rs2550929; rs459092; rs28382256; rs28382235; rs3836790; rs2927683; rs2975290; rs2963240; rs1677431; rs2652527; rs28363091; rs2963246; rs2652516; rs28382241; rs2652520; rs10582066; rs638964; rs11362775; rs10569377; rs28363102; rs13178805; rs2735913; rs10071624; rs2735929; rs28363131; rs35354514; rs2617611; rs2735922; rs2550924; rs2652519; rs2735914; rs36154293; rs12332091; rs11741877; rs28363070; rs28382239; rs28363087; rs28382226; rs2937642; rs439028; rs28363097; rs423091; rs420334; rs28363107; rs28742609; rs2963244; rs28363122; rs10078288; rs2550938; rs34389905; rs2652532; rs2249823; rs28382240; rs2550958; rs2652524; rs2735926; rs2550928; rs28382236; rs418265; rs28363165; rs11564760; rs2927682; rs13186941; rs28363148; rs11442679; rs34110245; rs501965; rs28363068; rs3776508; rs28363110; rs13171176; rs2550937; rs2859605; rs35841133; rs34211901; rs28380002; rs250685; rs2652525; rs28363084; rs2550933; rs28363136; rs2735932; rs2735916; rs34128392; rs28382249; rs183125; rs2963250; rs28363073; rs371742; rs28382255; rs2963247; rs34976394; rs11273210; rs2617609; rs11564770; rs2617608; rs34049355; rs6880255; rs638577; rs2249815; rs438260; rs28363096; rs11741780; rs2735923; rs13155096; rs36082016; rs34639188; rs2617612; rs168682; rs181776; rs2975285; rs28419783; rs34389111; rs369333; rs28363118; rs28363132; rs10069101; rs28382225; rs28363146; rs28364999; rs27049; rs13163094; rs34946486; rs28407730; rs2652531; rs409928; rs36050264; rs28363158; rs28382231; rs2617580; rs28363164; rs2550932; rs2652517; rs2550923; rs4975640; rs624466; rs2911491; rs28363093; rs2652529; rs2550922; rs2617576; rs13155226; rs2735915; rs28382243; rs10063564; rs28363143; rs28382253; rs2652526; rs2735927; rs2735909; rs28363100; rs28363137; rs37014; rs181775; rs3836789; rs2735920; rs2735931; rs2550926; rs11306694; rs2859606; rs28363121; rs28382258; rs2550927; rs2652518; rs28382229; rs452603; rs28363105; rs2550931; rs2963248; rs34079488; rs28363147; rs2652528; rs10569379; rs2937647; rs35563174; rs28382232; rs28363162; rs2652530; rs2975286; rs2735924; rs2927681; rs2652521; rs34542332; rs28382224; rs6879732; rs2937644; rs2617606; rs3776510; rs2975287; rs185034; rs29001606; rs28363134; rs28363095; rs3822458; rs2617579; rs386538; rs384907; rs9312865; rs28363103; rs624846; rs28382227; rs35190238; rs13162153; rs28363140; rs28363075; rs28382223; rs2652523; rs2735918; rs10069463; rs2963249; rs10072809; rs417608; rs2963251; rs35230954; rs2550935; rs28363128; rs2550930; rs28363088; rs35762146; rs10569378; rs11344041; rs2927684; rs1614919; rs5865370; rs11738604; rs10475005; rs380689; rs2735930; rs375636; rs28363112; rs2859607; rs28363145; rs430512; rs2975289; rs2735928; rs2963245; rs2735921; rs28363144; rs28651372; rs2735908; rs28382233; rs2550959; rs11745189; rs9312866; rs2617607; rs2652515; rs28363108; rs13357809; rs2249538; rs2550925; rs28382250; rs35789472; rs41282615; rs28363123; rs28363130; rs2735911; rs2550934; rs28363127; rs28363081; rs28363071; rs6895518; rs462293; rs401235; rs410246; rs28363163; rs460819; rs2937641; rs28363094; rs6862677; rs2735925; rs2617610; rs2652522; rs2927680; rs408023; rs368273; rs909242; rs28363150; rs451561; rs461854; rs2975288; rs28363135; rs2617578; rs2735852; rs28969507; rs2550957; rs2617598; rs28363183; rs2937637; rs28363184; rs2735853; rs4029364; rs34076103; rs28363180; rs4029363; rs28363176; rs28363186; rs2617597; rs27995; rs28363182; rs10051714; rs10063727; rs10064219; rs10079348; rs11742490; rs11744775; rs12332463; rs12516758; rs13164174; rs13189021; rs1478434; rs2078247; rs2254255; rs2254408; rs2270913; rs2447848; rs2447849; rs2447850; rs2471921; rs2471926; rs2516290; rs2516291; rs2550939; rs2550948; rs2550949; rs2550950; rs2550951; rs2550952; rs2550953; rs2550954; rs2550955; rs2550956; rs2550965; rs2550966; rs2550967; rs2617588; rs2617589; rs2617590; rs2617591; rs2617592; rs2617594; rs2617599; rs2617600; rs2617601; rs2617602; rs2617603; rs2617604; rs2652508; rs2652510; rs27073; rs27074; rs2735847; rs2735848; rs2735849; rs2735850; rs2735851; rs2735855; rs2735856; rs2735857; rs2735934; rs2859604; rs2911493; rs2937629; rs2937635; rs2963238; rs2963256; rs2975225; rs2981359; rs3756450; rs3776485; rs456323; rs464528; rs6346; rs6350; rs8179023

# Macromolecular_Interacting_Partner_17_General_References:
1359373; 1406597; 8302271; 9300814; 10889531; 11304827; 7637582; 1353885; 11343649; 10391209

# Macromolecular_Interacting_Partner_17_References:
16733047; 16733058; 16753267; 16767419

# Macromolecular_Interacting_Partner_18_ID:
7984

# Macromolecular_Interacting_Partner_18_Name:
Synaptic vesicular amine transporter

# Macromolecular_Interacting_Partner_18_Synonyms:
Monoamine transporter; Vesicular amine transporter 2; VAT2; Solute carrier family 18 member 2

# Macromolecular_Interacting_Partner_18_Gene_Name:
SLC18A2

# Macromolecular_Interacting_Partner_18_Protein_Sequence:
>Synaptic vesicular amine transporter
MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEI
QTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSE
DKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSS
SYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGS
VLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGS
ICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLC
ALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGS
VYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKM
AILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD

# Macromolecular_Interacting_Partner_18_Number_of_Residues:
514

# Macromolecular_Interacting_Partner_18_Molecular_Weight:
55714

# Macromolecular_Interacting_Partner_18_Theoretical_pI:
5.91

# Macromolecular_Interacting_Partner_18_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_18_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_18_Specific_Function:
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis

# Macromolecular_Interacting_Partner_18_Pathway:
Not Available

# Macromolecular_Interacting_Partner_18_Reaction:
Not Available

# Macromolecular_Interacting_Partner_18_Pfam_Domain_Function:
PF07690:MFS_1

# Macromolecular_Interacting_Partner_18_Signals:
1-37

# Macromolecular_Interacting_Partner_18_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_18_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_18_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_18_GenBank_ID_Protein:
292335

# Macromolecular_Interacting_Partner_18_SwissProt_ID:
VMAT2_HUMAN (Q05940)

# Macromolecular_Interacting_Partner_18_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_18_Genecard_id:
SLC18A2

# Macromolecular_Interacting_Partner_18_Geneatlas_id:
SLC18A2

# Macromolecular_Interacting_Partner_18_hgnc_id:
HGNC:10935

# Macromolecular_Interacting_Partner_18_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_18_Subcellular_Location:
Cytoplasmic vesicle; cytoplasmic vesicle membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_18_Gene_Sequence:
>1545 bp
ATGGCCCTGAGCGAGCTGGCGCTGGTCCGCTGGCTGCAGGAGAGCCGCCGCTCGCGGAAG
CTCATCCTGTTCATCGTGTTCCTGGCGCTGCTGCTGGACAACATGCTGCTCACTGTCGTG
GTCCCCATCATCCCAAGTTATCTGTACAGCATTAAGCATGAGAAGAATGCTACAGAAATC
CAGACGGCCAGGCCAGTGCACACTGCCTCCATCTCAGACAGCTTCCAGAGCATCTTCTCC
TATTATGATAACTCGACTATGGTCACCGGGAATGCTACCAGAGACCTGACACTTCATCAG
ACCGCCACACAGCACATGGTGACCAACGCGTCCGCTGTTCCTTCCGACTGTCCCAGTGAA
GACAAAGACCTCCTGAATGAAAACGTGCAAGTTGGTCTGTTGTTTGCCTCGAAAGCCACC
GTCCAGCTCATCACCAACCCTTTCATAGGACTACTGACCAACAGAATTGGCTATCCAATT
CCCATATTTGCGGGATTCTGCATCATGTTTGTCTCAACAATTATGTTTGCCTTCTCCAGC
AGCTATGCCTTCCTGCTGATTGCCAGGTCGCTGCAGGGCATCGGCTCGTCCTGCTCCTCT
GTGGCTGGGATGGGCATGCTTGCCAGTGTCTACACAGATGATGAAGAGAGAGGCAACGTC
ATGGGAATCGCCTTGGGAGGCCTGGCCATGGGGGTCTTAGTGGGCCCCCCCTTCGGGAGT
GTGCTCTATGAGTTTGTGGGGAAGACGGCTCCGTTCCTGGTGCTGGCCGCCCTGGTACTC
TTGGATGGAGCTATTCAGCTCTTTGTGCTCCAGCCGTCCCGGGTGCAGCCAGAGAGTCAG
AAGGGGACACCCCTAACCACGCTGCTGAAGGACCCGTACATCCTCATTGCTGCAGGCTCC
ATCTCCTTTGCAAACATGGGCATCGCCATGCTGGAGCCAGCCCTGCCCATCTGGATGATG
GAGACCATGTGTTCCCGCAAGTGGCAGCTGGGCGTTGCCTTCTTGCCAGCTAGTATCTCT
TATCTCATTGGAACCAATATTTTTGGGATACTTGCACACACAATGGGGAGGTGGCTTTGT
GCTCTTCTGGGAATGATAATTGTTGGAGTCAGCATTTTATGTATTCCATTTCCAAAAAAC
ATTTATGGACTCATAGCTCCGAACTTTGGAGTTGGTTTTGCAAATGGAATGGTGGATTCG
TCAATGATGCCTATCATGGGCTACCTCGTAGACCTGCGGCACGTGTCCGTCTATGGGAGT
GTGTACGCCATTGCGGATGTGGCATTTTGTATGGGGTATGCTATAGGTCCTTCTGCTGGT
GGTGCTATTGCAAAGGCAATTGGATTTCCATGGCTCATGACAATTATTGGGATAATTGAT
ATTCTTTTTGCCCCTCTCTGCTTTTTTCTTCGAAGTCCACCTGCCAAAGAAGAAAAAATG
GCTATTCTCATGGATCACAACTGCCCTATTAAAACAAAAATGTACACTCAGAATAATATC
CAGTCATATCCGATAGGTGAAGATGAAGAATCTGAAAGTGACTGA

# Macromolecular_Interacting_Partner_18_GenBank_ID_Gene:
L09118

# Macromolecular_Interacting_Partner_18_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_18_Locus:
10q25

# Macromolecular_Interacting_Partner_18_SNPs:
rs363387; rs363388; rs363411; rs14240; rs10377; rs363280; rs2244375; rs363278; rs363272; rs363271; rs363337; rs363226; rs2015586; rs3523; rs363227; rs363276; rs363275; rs363262; rs363224; rs1860404; rs363417; rs363232; rs363231; rs2255321; rs363228; rs363221; rs363263; rs4752045; rs7085251; rs363223; rs363397; rs2072362; rs10082463; rs363332; rs11817133; rs2803812; rs363413; rs363252; rs2283138; rs363400; rs363404; rs363405; rs363248; rs363334; rs363341; rs363225; rs363251; rs2283139; rs363279; rs363401; rs363247; rs3753127; rs363338; rs363396; rs363395; rs363222; rs363336; rs363277; rs363256; rs363390; rs363394; rs363398; rs363342; rs3026060; rs363333; rs363253; rs2244249; rs2072364; rs363389; rs929493; rs11568725; rs363269; rs363408; rs2283142; rs2532809; rs363393; rs363230; rs363343; rs363270; rs7095278; rs2803811; rs363335; rs12251984; rs2532805; rs2255062; rs363266; rs363220; rs363340; rs363246; rs363418; rs363260; rs7099216; rs2532808; rs7899301; rs363265; rs363391; rs17095973; rs363257; rs363420; rs2803815; rs363273; rs363245; rs2299615; rs363268; rs363249; rs11819661; rs2532807; rs363406; rs3026052; rs363407; rs11197936; rs7085415; rs2072363; rs2619093; rs363386; rs11816858; rs363250; rs363399; rs2283141; rs363229; rs2256299; rs363254; rs2240779; rs7100827; rs363264; rs363412; rs2283136; rs363419; rs363416; rs2532806; rs363409; rs11197932; rs11817105; rs2255063; rs363385; rs2283137; rs363281; rs2619095; rs12412905; rs11197931; rs3026051; rs1042543; rs2619094; rs35772469; rs35606571; rs3026065; rs2429507; rs363261; rs12217714; rs36022272; rs3026053; rs11197938; rs34299747; rs12358252; rs12359740; rs363384; rs12254490; rs363258; rs35868817; rs3026056; rs11197934; rs2270143; rs12354804; rs36039915; rs2532810; rs12359442; rs34784034; rs35866947; rs3026061; rs363392; rs3026070; rs11369697; rs35000397; rs363402; rs3026057; rs363244; rs363410; rs34975750; rs3026062; rs3026069; rs36079170; rs12781403; rs17096012; rs3026068; rs35114321; rs35533634; rs363255; rs3026058; rs34291858; rs34672616; rs36083737; rs7088569; rs3026064; rs3026067; rs11313765; rs41284384; rs35784393; rs11197933; rs2254950; rs34235015; rs35317678; rs34855821; rs363414; rs3026063; rs11433861; rs363339; rs3026055; rs2803813; rs3026066; rs12263683; rs7894469; rs36080619; rs35584666; rs17543336; rs363259; rs363267; rs4751619; rs363415; rs36075729; rs3026054; rs2429506; rs917584; rs11197935; rs12217705; rs12412553; rs7898581; rs34318947; rs2532804; rs2532803; rs2283135; rs10424; rs10886050; rs10886051; rs11197939; rs11197940; rs11568718; rs11568719; rs11568720; rs11568722; rs12266296; rs12337; rs2532801; rs2619097; rs2848; rs3026049; rs3026050; rs34094598; rs34323464; rs35664484; rs363235; rs363236; rs363238; rs363241; rs363242; rs363282; rs363283; rs363284; rs363285; rs363286; rs363287; rs363288; rs363290; rs363291; rs363292; rs363293; rs363294; rs363295; rs363296; rs363297; rs363298; rs363327; rs363328; rs363329; rs363330; rs363373; rs363374; rs363375; rs363376; rs363377; rs363378; rs363379; rs363380; rs363381; rs363383

# Macromolecular_Interacting_Partner_18_General_References:
8095030; 8245983; 7905859; 11443533; 12009896

# Macromolecular_Interacting_Partner_18_References:
16741673; 17052844; 17100850; 17105913

# Macromolecular_Interacting_Partner_19_ID:
7871

# Macromolecular_Interacting_Partner_19_Name:
Neuropeptide S receptor

# Macromolecular_Interacting_Partner_19_Synonyms:
G-protein coupled receptor 154; G-protein coupled receptor for asthma susceptibility; G-protein coupled receptor PGR14

# Macromolecular_Interacting_Partner_19_Gene_Name:
NPSR1

# Macromolecular_Interacting_Partner_19_Protein_Sequence:
>Neuropeptide S receptor
MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLF
VFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLV
CRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIP
TLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIK
SKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFN
LLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERH
EMQILSKPEFI

# Macromolecular_Interacting_Partner_19_Number_of_Residues:
371

# Macromolecular_Interacting_Partner_19_Molecular_Weight:
42687

# Macromolecular_Interacting_Partner_19_Theoretical_pI:
8.44

# Macromolecular_Interacting_Partner_19_GO_Classification:
>>>
Function:  peptide receptor activity, G-protein coupled
Function:  vasopressin-like receptor activity
Function:  vasopressin receptor activity
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_19_General_Function:
Not Available

# Macromolecular_Interacting_Partner_19_Specific_Function:
May be active in signaling pathway in an autocrine or paracrine fashion in several tissues. Receptor for neuropeptide S, it may mediate its action, such as inhibitory effects, on cell growth. Involved in pathogenesis of asthma and other IgE-mediated diseases

# Macromolecular_Interacting_Partner_19_Pathway:
Not Available

# Macromolecular_Interacting_Partner_19_Reaction:
Not Available

# Macromolecular_Interacting_Partner_19_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_19_Signals:
None

# Macromolecular_Interacting_Partner_19_Transmembrane_Regions:
53-73
83-103
124-144
165-185
213-233
276-296
313-333

# Macromolecular_Interacting_Partner_19_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_19_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_19_GenBank_ID_Protein:
34596864

# Macromolecular_Interacting_Partner_19_SwissProt_ID:
NPSR1_HUMAN (Q6W5P4)

# Macromolecular_Interacting_Partner_19_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_19_Genecard_id:
NPSR1

# Macromolecular_Interacting_Partner_19_Geneatlas_id:
NPSR1

# Macromolecular_Interacting_Partner_19_hgnc_id:
HGNC:23631

# Macromolecular_Interacting_Partner_19_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_19_Subcellular_Location:
Isoform 1:Cell membrane; multi-pass membrane protein. Isoform 3:Cell membrane; multi-pass membrane protein. Isoform 4:Cell membrane; multi-pass membrane protein. Isoform 2:Cytoplasm. Isoform 5:Cytoplasm. Isoform 6:Cytoplasm. Isoform 7:Cytoplasm. Isoform 9:Cytoplasm

# Macromolecular_Interacting_Partner_19_Gene_Sequence:
>1116 bp
ATGCCAGCCAACTTCACAGAGGGCAGCTTCGATTCCAGTGGGACCGGGCAGACGCTGGAT
TCTTCCCCAGTGGCTTGCACTGAAACAGTGACTTTTACTGAAGTGGTGGAAGGAAAGGAA
TGGGGTTCCTTCTACTACTCCTTTAAGACTGAGCAATTGATAACTCTGTGGGTCCTCTTT
GTTTTTACCATTGTTGGAAACTCCGTTGTGCTTTTTTCCACATGGAGGAGAAAGAAGAAG
TCAAGAATGACCTTCTTTGTGACTCAGCTGGCCATCACAGATTCTTTCACAGGACTGGTC
AACATCTTGACAGATATTAATTGGCGATTCACTGGAGACTTCACGGCACCTGACCTGGTT
TGCCGAGTGGTCCGCTATTTGCAGGTTGTGCTGCTCTACGCCTCTACCTACGTCCTGGTG
TCCCTCAGCATAGACAGATACCATGCCATCGTCTACCCCATGAAGTTCCTTCAAGGAGAA
AAGCAAGCCAGGGTCCTCATTGTGATCGCCTGGAGCCTGTCTTTTCTGTTCTCCATTCCC
ACCCTGATCATATTTGGGAAGAGGACACTGTCCAACGGTGAAGTGCAGTGCTGGGCCCTG
TGGCCTGACGACTCCTACTGGACCCCATACATGACCATCGTGGCCTTCCTGGTGTACTTC
ATCCCTCTGACAATCATCAGCATCATGTATGGCATTGTGATCCGAACTATTTGGATTAAA
AGCAAAACCTACGAAACAGTGATTTCCAACTGCTCAGATGGGAAACTGTGCAGCAGCTAT
AACCGAGGACTCATCTCAAAGGCAAAAATCAAGGCTATCAAGTATAGCATCATCATCATT
CTTGCCTTCATCTGCTGTTGGAGTCCATACTTCCTGTTTGACATTTTGGACAATTTCAAC
CTCCTTCCAGACACCCAGGAGCGTTTCTATGCCTCTGTGATCATTCAGAACCTGCCAGCA
TTGAATAGTGCCATCAACCCCCTCATCTACTGTGTCTTCAGCAGCTCCATCTCTTTCCCC
TGCAGGGAGCAAAGATCACAGGATTCCAGAATGACGTTCCGGGAGAGAACTGAGAGGCAT
GAGATGCAGATTCTGTCCAAGCCAGAATTCATCTAG

# Macromolecular_Interacting_Partner_19_GenBank_ID_Gene:
AY310326

# Macromolecular_Interacting_Partner_19_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_19_Locus:
7p14.3

# Macromolecular_Interacting_Partner_19_SNPs:
rs7809642; rs10243897; rs7805675; rs12701391; rs11979944; rs13229970; rs6978087; rs11769430; rs11769407; rs13310747; rs13310840; rs13230135; rs28480169; rs13307415; rs13227114; rs13438159; rs13243083; rs13307507; rs13307244; rs13235984; rs13227229; rs13222976; rs28699135; rs13243490; rs2097858; rs12701392; rs5883476; rs34903149; rs13243621; rs2392287; rs28576287; rs13307778; rs34157915; rs13310444; rs35295382; rs4000112; rs1894745; rs4087728; rs2392286; rs13243494; rs10268842; rs13328346; rs6958041; rs7811879; rs13310855; rs1894746; rs13243373; rs12701390; rs2893487; rs13307570; rs36066201; rs28590377; rs1006392; rs1006393; rs1006394; rs10081183; rs10081224; rs1013126; rs10215263; rs10215901; rs10215941; rs10225627; rs10225759; rs10226373; rs10230162; rs10230379; rs10230513; rs10232363; rs10233723; rs1023555; rs1023556; rs10235636; rs10235648; rs10238983; rs10239860; rs10240711; rs10240801; rs10241507; rs10241616; rs10241737; rs10241772; rs10242970; rs10243634; rs10243849; rs10244389; rs10244603; rs10245014; rs10245329; rs10246825; rs10249085; rs10249271; rs10249606; rs10249614; rs10250336; rs10250709; rs10251302; rs10251716; rs10253137; rs10253465; rs10255950; rs10255979; rs10255999; rs10256489; rs10257063; rs10257646; rs10258734; rs10259175; rs10259788; rs10261743; rs10263313; rs10263447; rs10265037; rs10265775; rs10267134; rs10267935; rs10269284; rs10269806; rs10269833; rs10270663; rs10270766; rs10271262; rs10271686; rs10273903; rs10274146; rs10275028; rs10275644; rs10276528; rs10278663; rs10279907; rs10280995; rs10282306; rs10486653; rs10486655; rs10486656; rs10486657; rs10951425; rs10951426; rs11486758; rs11761093; rs11761197; rs11761288; rs11762538; rs11762584; rs11762763; rs11763481; rs11764535; rs11765573; rs11767110; rs11768189; rs11770143; rs11770325; rs11770777; rs11771396; rs11771425; rs11771697; rs11773493; rs11970820; rs11972817; rs11973406; rs11974932; rs11975122; rs11976769; rs11978538; rs11979661; rs11979833; rs11980520; rs11981253; rs11982905; rs11983674; rs12111597; rs12154551; rs12530657; rs12532883; rs12534336; rs12534369; rs12670834; rs12672298; rs12673132; rs12701383; rs12701388; rs13222249; rs13226161; rs13226168; rs13226345; rs13231222; rs13231258; rs13235228; rs13238088; rs13240651; rs13245684; rs13246028; rs13246143; rs13309682; rs13340537; rs1345267; rs1345270; rs1362176; rs1362177; rs1362193; rs1379923; rs1379924; rs1379925; rs1379927; rs1379928; rs1419779; rs1419780; rs1419789; rs1419790; rs1419791; rs1419792; rs1419793; rs1419794; rs1419795; rs1419796; rs1419797; rs1419835; rs1419836; rs1419837; rs1419867; rs1419868; rs1458532; rs1458533; rs1458534; rs1458535; rs1458536; rs1458537; rs1458538; rs1458539; rs1458541; rs1458543; rs1458544; rs1458545; rs1458546; rs1458547; rs1458548; rs1458550; rs1563687; rs1585255; rs1592418; rs1592423; rs1592441; rs17150824; rs17169964; rs17169985; rs17169992; rs17169993; rs17169994; rs17169995; rs17170001; rs17170011; rs17170012; rs17170013; rs17170015; rs17170017; rs17170021; rs17189135; rs17189268; rs17197425; rs17197589; rs17197848; rs17197911; rs17198065; rs17198093; rs17198163; rs17198254; rs17198624; rs17198982; rs17199395; rs17199458; rs17199659; rs17199818; rs17199853; rs17199888; rs17200135; rs17200455; rs172868; rs17776082; rs17776235; rs17776257; rs17776930; rs17777040; rs17777441; rs17777663; rs17777675; rs17788770; rs17788843; rs17789096; rs17789287; rs17789420; rs17789432; rs17789456; rs17789480; rs17789624; rs17789642; rs17789834; rs17790181; rs17790961; rs182718; rs184448; rs1860369; rs1860370; rs1963499; rs2021374; rs2022142; rs2023529; rs2023530; rs2109124; rs2125403; rs2125404; rs2125406; rs2168890; rs2168891; rs2168892; rs2215144; rs2215293; rs2392276; rs2392285; rs2529494; rs2530531; rs2530536; rs2530539; rs2530543; rs2530544; rs2530545; rs2530546; rs2530547; rs2530548; rs2530549; rs2530550; rs2530551; rs2530552; rs2530553; rs2530554; rs2530556; rs2530557; rs2530558; rs2530559; rs2530560; rs2530561; rs2530564; rs2530565; rs2530566; rs2530567; rs2530568; rs2530569; rs2530570; rs2530571; rs2530572; rs2531837; rs2531838; rs2531839; rs2531840; rs2609210; rs2609211; rs2609212; rs2609214; rs2609215; rs2609216; rs2609217; rs2609218; rs2609219; rs2609220; rs2609222; rs2609223; rs2609224; rs2609226; rs2609227; rs2609228; rs2609229; rs2609231; rs2609233; rs2609234; rs2609242; rs2609252; rs323907; rs323909; rs323910; rs323911; rs323912; rs323913; rs323914; rs323916; rs323917; rs323918; rs323920; rs323922; rs323925; rs324372; rs324373; rs324374; rs324375; rs324376; rs324377; rs324380; rs324381; rs324383; rs324386; rs324389; rs324392; rs324393; rs324395; rs324397; rs324398; rs324399; rs324956; rs324957; rs324958; rs324959; rs324960; rs324961; rs324962; rs324963; rs324964; rs324965; rs324966; rs324967; rs324968; rs324975; rs324976; rs324977; rs324978; rs324980; rs324981; rs324982; rs324983; rs324984; rs324985; rs324986; rs324987; rs324989; rs325454; rs325456; rs325457; rs325459; rs325462; rs325463; rs325464; rs325465; rs325466; rs325467; rs325468; rs325477; rs33927965; rs33956262; rs34609357; rs34683710; rs34724449; rs35029494; rs35260880; rs35534471; rs35785627; rs35878152; rs35992792; rs376825; rs401256; rs411323; rs411791; rs4141216; rs423282; rs425990; rs4272270; rs438778; rs450463; rs4580944; rs5005133; rs6462579; rs6462580; rs6946103; rs6947323; rs6947841; rs6949087; rs6952485; rs6952922; rs6953479; rs6956356; rs6956463; rs6957501; rs6957774; rs6958905; rs6960864; rs6960952; rs6961859; rs6962757; rs6964821; rs6964828; rs6970989; rs6972158; rs6975521; rs6975546; rs6976985; rs6977332; rs6977729; rs6979428; rs714588; rs725902; rs727162; rs7357323; rs740347; rs740623; rs740717; rs740718; rs740723; rs7457172; rs758399; rs764268; rs764269; rs765023; rs7792476; rs7794853; rs7804942; rs7806620; rs7812206; rs887020; rs898067; rs898068; rs898069; rs898070; rs898071; rs963218; rs963219; rs963220; rs9648043; rs9655357; rs9655359; rs9792042; rs988367; rs9986878

# Macromolecular_Interacting_Partner_19_General_References:
Not Available

# Macromolecular_Interacting_Partner_19_References:
17066056

# Macromolecular_Interacting_Partner_20_ID:
8799

# Macromolecular_Interacting_Partner_20_Name:
Monooxygenase, DBH-like 1

# Macromolecular_Interacting_Partner_20_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_20_Gene_Name:
MOXD1

# Macromolecular_Interacting_Partner_20_Protein_Sequence:
>Monooxygenase, DBHlike 1
MNSFLSVFRYPDFSFPYFPQDYFTNANRELKKDAQQDYHLEYAMENSTHTIIEFTRELHT
CDINDKSITDSTVRVIWAYHHEDAGEAGPKYHDSNRGTKSLRLLNPEKTSVLSTALPYFD
LVNQDVPIPNKDTTYWCQMFKIPVFQEKHHVIKVEPVIQRGHESLVHHILLYQCSNNFND
SVLESGHECYHPNMPDAFLTCETVIFAWAIGGEGFSYPPHVGLSLGTPLDPHYVLLEVHY
DNPTYEEGLIDNSGLRLFYTMDIRKYDAGVIEAGLWVSLFHTIPPGMPEFQSEGHCTLEC
LEEALEAEKPSGIHVFAVLLHAHLAGRGIRLRHFRKGKEMKLLAYDDDFDFNFQEFQYLK
EEQTILPGDNLITECRYNTKDRAEMTWGGLSTRSEMCLSYLLYYPRINLTRCASIPDIME
QLQFIGVKEIYRPVTTWPFIIKSPKQYKNLSFMDAMNKFKWTKKEGLSFNKLVLSLPVNV
RCSKTDNAEWSIQGMTALPPDIERPYKAEPLVCGTSSSSSLHRDFSINLLVCLLLLSCTL
STKSL

# Macromolecular_Interacting_Partner_20_Number_of_Residues:
545

# Macromolecular_Interacting_Partner_20_Molecular_Weight:
62701

# Macromolecular_Interacting_Partner_20_Theoretical_pI:
6.01

# Macromolecular_Interacting_Partner_20_GO_Classification:
>>>
 Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
Function:  dopamine beta-monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  catecholamine metabolism
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_20_General_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Pathway:
Not Available

# Macromolecular_Interacting_Partner_20_Reaction:
Not Available

# Macromolecular_Interacting_Partner_20_Pfam_Domain_Function:
PF03712:Cu2_monoox_C
PF01082:Cu2_monooxygen

# Macromolecular_Interacting_Partner_20_Signals:
Not Available

# Macromolecular_Interacting_Partner_20_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_20_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_20_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_20_GenBank_ID_Protein:
56202500

# Macromolecular_Interacting_Partner_20_SwissProt_ID:
Q5THU6_HUMAN (Q5THU6)

# Macromolecular_Interacting_Partner_20_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_20_Genecard_id:
MOXD1

# Macromolecular_Interacting_Partner_20_Geneatlas_id:
MOXD1

# Macromolecular_Interacting_Partner_20_hgnc_id:
HGNC:21063

# Macromolecular_Interacting_Partner_20_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_20_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_20_Gene_Sequence:
>1179 bp
GTTGAGCCAGTGATACAGAGAGGCCATGAGAGTCTGGTGCACCACATCCTGCTCTATCAG
TGCAGCAACAACTTTAACGACAGCGTTCTGGAGTCCGGCCACGAGTGCTATCACCCCAAC
ATGCCCGATGCATTCCTCACCTGTGAAACTGTGATTTTTGCCTGGGCTATTGGTGGAGAG
GGCTTTTCTTATCCACCTCATGTTGGATTATCCCTTGGCACTCCATTAGATCCGCATTAT
GTGCTCCTAGAAGTCCATTATGATAATCCCACTTATGAGGAAGGCTTAATAGATAATTCT
GGACTGAGGTTATTTTACACAATGGATATAAGGAAATATGATGCTGGGGTGATTGAGGCT
GGCCTCTGGGTGAGCCTCTTCCATACCATCCCTCCAGGGATGCCTGAGTTCCAGTCTGAG
GGTCACTGCACTTTGGAGTGCCTGGAAGAGGCTCTGGAAGCCGAAAAGCCAAGTGGAATT
CATGTGTTTGCTGTTCTTCTCCATGCTCACCTGGCTGGCAGAGGCATCAGGCTGCGTCAT
TTTCGAAAAGGGAAGGAAATGAAATTACTTGCCTATGATGATGATTTTGACTTCAATTTC
CAGGAGTTTCAGTATCTAAAGGAAGAACAAACAATCTTACCAGGAGATAACCTAATTACT
GAGTGTCGCTACAACACGAAAGATAGAGCTGAGATGACTTGGGGAGGACTAAGCACCAGG
AGTGAAATGTGTCTCTCATACCTTCTTTATTACCCAAGAATTAATCTTACTCGATGTGCA
AGTATTCCAGACATTATGGAACAACTTCAGTTCATTGGGGTTAAGGAGATCTACAGACCA
GTCACGACCTGGCCTTTCATTATCAAAAGTCCCAAGCAATATAAAAACCTTTCTTTCATG
GATGCTATGAATAAGTTTAAATGGACTAAAAAGGAAGGTCTCTCCTTCAACAAGCTGGTC
CTCAGCCTGCCAGTGAATGTGAGATGTTCCAAGACAGACAATGCTGAGTGGTCGATTCAA
GGAATGACAGCATTACCTCCAGATATAGAAAGACCCTATAAAGCAGAACCTTTGGTGTGT
GGCACGTCTTCTTCCTCTTCCCTGCACAGAGATTTCTCCATCAACTTGCTTGTTTGCCTT
CTGCTACTCAGCTGCACGCTGAGCACCAAGAGCTTGTGA

# Macromolecular_Interacting_Partner_20_GenBank_ID_Gene:
AL023578

# Macromolecular_Interacting_Partner_20_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_20_Locus:
6q23.1-23.3

# Macromolecular_Interacting_Partner_20_SNPs:
Not Available

# Macromolecular_Interacting_Partner_20_General_References:
Not Available

# Macromolecular_Interacting_Partner_20_References:
Not Available

# Macromolecular_Interacting_Partner_21_ID:
8841

# Macromolecular_Interacting_Partner_21_Name:
Chromaffin granule amine transporter

# Macromolecular_Interacting_Partner_21_Synonyms:
Vesicular amine transporter 1; VAT1; Solute carrier family 18 member 1

# Macromolecular_Interacting_Partner_21_Gene_Name:
SLC18A1

# Macromolecular_Interacting_Partner_21_Protein_Sequence:
>Chromaffin granule amine transporter
MLRTILDAPQRLLKEGRASRQLVLVVVFVALLLDNMLFTVVVPIVPTFLYDMEFKEVNSS
LHLGHAGSSPHALASPAFSTIFSFFNNNTVAVEESVPSGIAWMNDTASTIPPPATEAISA
HKNNCLQGTGFLEEEITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLS
TVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGL
LVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLFMLLKDP
YILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLA
NKMGRWLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDL
RHTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVINIVYAPLCYYLRS
PPAKEEKLAILSQDCPMETRMYATQKPTKEFPLGEDSDEEPDHEE

# Macromolecular_Interacting_Partner_21_Number_of_Residues:
525

# Macromolecular_Interacting_Partner_21_Molecular_Weight:
56258

# Macromolecular_Interacting_Partner_21_Theoretical_pI:
5.79

# Macromolecular_Interacting_Partner_21_GO_Classification:
>>>
 Function:  transporter activity
Function:  drug transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  drug transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_21_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_21_Specific_Function:
Involved in the vesicular transport of biogenic amines

# Macromolecular_Interacting_Partner_21_Pathway:
Not Available

# Macromolecular_Interacting_Partner_21_Reaction:
Not Available

# Macromolecular_Interacting_Partner_21_Pfam_Domain_Function:
PF07690:MFS_1

# Macromolecular_Interacting_Partner_21_Signals:
1-39

# Macromolecular_Interacting_Partner_21_Transmembrane_Regions:
22-42
139-158
168-188
198-218
228-250
257-279
300-319
336-360
366-386
398-418
423-443
449-470

# Macromolecular_Interacting_Partner_21_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_21_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_21_GenBank_ID_Protein:
1314290

# Macromolecular_Interacting_Partner_21_SwissProt_ID:
VMAT1_HUMAN (P54219)

# Macromolecular_Interacting_Partner_21_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_21_Genecard_id:
SLC18A1

# Macromolecular_Interacting_Partner_21_Geneatlas_id:
SLC18A1

# Macromolecular_Interacting_Partner_21_hgnc_id:
HGNC:10934

# Macromolecular_Interacting_Partner_21_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_21_Subcellular_Location:
Cytoplasmic vesicle; cytoplasmic vesicle membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_21_Gene_Sequence:
>1578 bp
ATGCTCCGGACCATTCTGGATGCTCCCCAGCGGTTGCTGAAGGAGGGGAGAGCGTCCCGG
CAGCTGGTGCTGGTGGTGGTATTCGTCGCTTTGCTCCTGGACAACATGCTGTTTACTGTG
GTGGTGCCAATTGTGCCCACCTTCCTATATGACATGGAGTTCAAAGAAGTCAACTCTTCT
CTGCACCTCGGCCATGCCGGAAGTTCCCCACATGCCCTCGCCTCTCCTGCCTTTTCCACC
ATCTTCTCCTTCTTCAACAACAACACCGTGGCTGTTGAAGAAAGCGTACCTAGTGGAATA
GCATGGATGAATGACACTGCCAGCACCATCCCACCTCCAGCCACTGAAGCCATCTCAGCT
CATAAAAACAACTGCTTGCAAGGCACAGGTTTCTTGGAGGAAGAGATTACCCGGGTCGGG
GTTCTGTTTGCTTCAAAGGCTGTGATGCAACTTCTGGTCAACCCATTCGTGGGCCCTCTC
ACCAACAGGATTGGATATCATATCCCCATGTTTGCTGGCTTTGTTATCATGTTTCTCTCC
ACAGTTATGTTTGCTTTTTCTGGGACCTATACTCTACTCTTTGTGGCCCGAACCCTTCAA
GGCATTGGATCTTCATTTTCATCTGTTGCAGGTCTTGGAATGCTGGCCAGTGTCTACACT
GATGACCATGAGAGAGGACGAGCCATGGGAACTGCTCTGGGGGGCCTGGCCTTGGGGTTG
CTGGTGGGAGCTCCCTTTGGAAGTGTAATGTACGAGTTTGTTGGGAAGTCTGCACCCTTC
CTCATCCTGGCCTTCCTGGCACTACTGGATGGAGCACTCCAGCTTTGCATCCTACAGCCT
TCCAAAGTCTCTCCTGAGAGTGCCAAGGGGACTCCCCTCTTTATGCTTCTCAAAGACCCT
TACATCCTGGTGGCTGCAGGGTCCATCTGCTTTGCCAACATGGGGGTGGCCATCCTGGAG
CCCACACTGCCCATCTGGATGATGCAGACCATGTGCTCCCCCAAGTGGCAGCTGGGTCTA
GCTTTCTTGCCTGCCAGTGTGTCCTACCTCATTGGCACCAACCTCTTTGGTGTGTTGGCC
AACAAGATGGGTCGGTGGCTGTGTTCCCTAATCGGGATGCTGGTAGTAGGTACCAGCTTG
CTCTGTGTTCCTCTGGCTCACAATATTTTTGGTCTCATTGGCCCCAATGCAGGGCTTGGC
CTTGCCATAGGCATGGTGGATTCTTCTATGATGCCCATCATGGGGCACCTGGTGGATCTA
CGCCACACCTCGGTGTATGGGAGTGTCTACGCCATCGCTGATGTGGCTTTTTGCATGGGC
TTTGCTATAGGTCCATCCACCGGTGGTGCCATTGTAAAGGCCATCGGTTTTCCCTGGCTC
ATGGTCATCACTGGGGTCATCAACATCGTCTATGCTCCACTCTGCTACTACCTGCGGAGC
CCCCCGGCAAAGGAAGAGAAGCTTGCTATTCTGAGTCAGGACTGCCCCATGGAGACCCGG
ATGTATGCAACCCAGAAGCCCACGAAGGAATTTCCTCTGGGGGAGGACAGTGATGAGGAG
CCTGACCATGAGGAGTAG

# Macromolecular_Interacting_Partner_21_GenBank_ID_Gene:
U39905

# Macromolecular_Interacting_Partner_21_Chromosome_Location:
Chromosome:8

# Macromolecular_Interacting_Partner_21_Locus:
8p21.3

# Macromolecular_Interacting_Partner_21_SNPs:
rs1390938; rs17092104; rs2270637; rs17215808; rs2270641; rs17215822; rs17215759; rs17092129; rs2270648; rs17222183; rs17215787; rs721950; rs12549838; rs1390939; rs1497020; rs12549837; rs4921694; rs2270642; rs4922137; rs13269955; rs2270644; rs2270643; rs721951; rs1908809; rs1532446; rs2132699; rs6586897; rs2088340; rs2088343; rs903997; rs952860; rs7006986; rs10112060; rs2279708; rs952858; rs6992927; rs1018079; rs6586896; rs1390942; rs13258461; rs952859; rs17092097; rs11204098; rs6992702; rs2279709; rs3735835; rs4922132; rs7841346; rs7013199; rs1497025; rs3779670; rs6586898; rs11989335; rs10102779; rs12545707; rs11987726; rs2270638; rs7014452; rs6982009; rs2270650; rs6986004; rs17092107; rs17222134; rs17411775; rs17489891; rs7007385; rs1390937; rs2015202; rs6989379; rs7827215; rs2132700; rs3779672; rs11989477; rs2270649; rs4921692; rs17092126; rs6994511; rs13266221; rs4922133; rs11774649; rs17489905; rs3779671; rs7820651; rs7011982; rs17840569; rs17092137; rs7014413; rs10216668; rs7002781; rs7828538; rs6987705; rs1813640; rs6997277; rs2088342; rs17092131; rs11986106; rs7812462; rs1497023; rs2270652; rs4921693; rs3779673; rs7010970; rs10283363; rs1497022; rs7828618; rs7010744; rs11204097; rs7003858; rs12547375; rs988713; rs11204096; rs13268842; rs17092083; rs3757960; rs7836907; rs17092144; rs13264938; rs2270645; rs17092091; rs34201967; rs4921695; rs2270647; rs34489221; rs2270646; rs3824122; rs9886453; rs35711001; rs36178996; rs13267563; rs34758432; rs10216526; rs13266515; rs34380936; rs7008229; rs10560327; rs17092106; rs28393220; rs13254049; rs28701666; rs7836082; rs34699818; rs5018722; rs34461999; rs2270639; rs7842711; rs10528221; rs13264769; rs34547886; rs4244460; rs6997438; rs11787343; rs2270640; rs17840570; rs11345261; rs7009177; rs13266227; rs35616580; rs35241387; rs34789619; rs7843545; rs2270651; rs13272341; rs17092136; rs36021577; rs35242639; rs34135174; rs35590614; rs34108083; rs4579546; rs3043842; rs28677856; rs13265473; rs2410637; rs17092132; rs34884871; rs2279710; rs28491510; rs7005635; rs11985004; rs10094232; rs36022472; rs28633772; rs28520251; rs34429137; rs28628307; rs34004632; rs28873390; rs13259196; rs34091371; rs35272127; rs28581346; rs28494669; rs10102445; rs13248157; rs13274124; rs34357050; rs34708641; rs34355694; rs6986634; rs28609982; rs10095858; rs28662172; rs35530484; rs34728683; rs17092115; rs33999400; rs6986377; rs13250997; rs13264146; rs34860475; rs2410636; rs35530901; rs6989871; rs10108611; rs34048931; rs7009166; rs34933233; rs17092134; rs28621370; rs5889901; rs10701629; rs35434077; rs35563299; rs28577098; rs6993213; rs35878337; rs28415506; rs10599153; rs2018681; rs28435279; rs35946395; rs35914215; rs2088341; rs36088196; rs17489926; rs10692089; rs34937185; rs35655118; rs12549750; rs2173113; rs1982960; rs3757959; rs3757958; rs34910259; rs3834367; rs10088489; rs10099144; rs10099366; rs11204095; rs11783752; rs11986163; rs11997907; rs12171680; rs13253037; rs13265218; rs13279675; rs13280941; rs17215717; rs17222106; rs17222127; rs17222141; rs17222148; rs17222155; rs2047360; rs2173114; rs35091123; rs3757961; rs4481613; rs4921691; rs4922131; rs6982939; rs7008859; rs7013494; rs7013942; rs7820517; rs987778

# Macromolecular_Interacting_Partner_21_General_References:
8643547

# Macromolecular_Interacting_Partner_21_References:
Not Available

End of HMDB00073

Beginning of HMDB00076
# Accession_No:
HMDB00076

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-14 12:15:29

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Dihydrouracil

# Description:
An intermediate breakdown product of uracil.  Dihydropyrimidine dehydrogenase catalyzes the reduction of uracil to 5, 6-dihydrouracil then dihydropyrimidinase hydrolyzes 5, 6-dihydrouracil to N-carbamyl-b-alanine. Finally, beta-ureidopropionase catalyzes the conversion of N-carbamyl-b-alanine to beta-alanine. Patients with dihydropyrimidinase deficiency (DPYS; also called 5, 6-dihydropyrimidine amidohydrolase, or DHP; EC 3.5.2.2) exhibit highly increased concentrations of 5, 6-dihydrouracil in urine. The direct measurement of the activity of DHP in patients had been hampered by the fact that the enzyme is expressed almost exclusively in liver tissue. Various neurological abnormalities have been described in this group of patients. (OMIM 222748)

# Synonyms:
5,6-Dihydro-2,4(1H,3H)-pyrimidinedione; 5,6-Dihydro-2,4-dihydroxypyrimidine; 5,6-Dihydrouracil; Dihydro-2,4(1H,3H)-pyrimidinedione; Dihydro-pyrimidine-2,4-dione; Dihydrouracil; Dihydrouracile; Hydrouracil

# Chemical_IUPAC_Name:
1,3-diazinane-2,4-dione

# Chemical_Formula:
C4H6N2O2

# Chemical_Structure:
tbl_chemical:::HMDB00076_ZOOM.png:::119283175615126428

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00076_THUMB.png:::119283175457644843

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
carboxylic acid imide, N-unsubstituted; urea; heterocyclic compound

# Taxonomy_Biofunction:
Component of beta-Alanine metabolism; Component of Pantothenate and CoA biosynthesis; Component of Pyrimidine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
114.04293

# Molecular_Weight_Avg:
114.10265

# Smiles_String_isomeric:
O=C1CCNC(=O)N1

# Smiles_String_canonical:
O=C1CCNC(=O)N1

# KEGG_Compound_ID:
C00429

# BioCyc_ID:
DI-H-URACIL

# PubChem_CID:
649

# PubChem_SID:
10391739; 1433808; 3138601; 6648; 10524386; 8145086; 630522; 76704; 5538666; 210281; 8150725; 841437; 7887221; 3718; 2631; 10322860

# OMIM_ID:
222748; 251850; 274270

# Metagene_ID:
DIHYDROPYRIMIDINASE (DHPA): 410

# BiGG_ID:
34956

# Wikipedia_ID:
Not Available

# METLIN_ID:
285

# Ref_ID:
14705962; 15726514; 9323563; 15729713; 15045945; 11106323; 8581129; 12798197; 12767347; 15726513; 15721430; 15737843; 11936689

# ChEBI_ID:
15901

# CAS_Registry_Number:
504-07-4

# InChI:
InChI=1/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8)

# Synthesis_Reference:
Metabolism of pyrimidines by proteolytic clostridia.     Hilton, Martin G.; Mead, Geoffrey C.; Elsden, Sidney R.    Food Res. Inst.,  Agric. Res. Counc.,  Norwich,  UK.    Archives of Microbiology  (1975),  102(2),  145-9.

# Melting_Point:
279-281 oC

# Melting_Point_predicted:
90.6 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
25.9 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-1.27 [Predicted by ALOGPS]; -1.2 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Dihydrouracil.mol:::1132723805312778489

# SDF_File_[Text]:
tbl_chemical:::HMDB00076.sdf:::119283175107567573

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00076.pdb:::119283175321088910

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::050122_P00_01_IS_1DP_presat.png:::114772882165490981

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::050122_P00_01_IS_1DP_presat.zip:::114772882173762165

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050122_P00_01_IS_1DP_Assigned.png:::114772882191160866

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050122_P00_01_IS.png:::117270670012230938

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050122_P00_01_IS.zip:::117270670084791283

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050122_P00_01_IS Assigned.png:::117270670331991005

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Dihydrouracil.gif:::1132732105812843834

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00076_peaks.txt:::1156309529684566151

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Dihydrouracil_C.gif:::1132737676234235773

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00076_peaks.txt:::1156310720048439634

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00076L.png:::117555262335788277; Medium Energy:tbl_ms:::HMDB00076M.png:::117555267686477330; High Energy:tbl_ms:::HMDB00076H.png:::117555271274754333

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Nucleus; Cytoplasm

# Tissue_Location:
Fibroblasts; Kidney; Liver

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	0.79	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	12798197
Urine	12.2 +/- 6.2	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	8581129
Blood	3.33 +/- 7.07	uM	Adult:>18_yrs_old	Both	Normal	11936689


# Concentration_[Abnormal]:
Urine	627.0	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Dihydropyrimidine dehydrogenase (DPD) deficiency	8581129
Cerebrospinal_Fluid(CSF)	81.5 (46.0-117.0)	uM	Adult:>18_yrs_old	Both	Dihydropyrimidine dehydrogenase (DPD) deficiency	14705962


# Associated_Disorders:
Dihydropyrimidine dehydrogenase (DPD) deficiency; Dpd Deficiency

# Pathway_Names:
Pantothenate and CoA biosynthesis

# Pathway_Images:
Not Available

# KEGG_Images:
map00770

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
6002

# Metabolic_Enzyme_1_Name:
Dihydropyrimidine dehydrogenase [NADP+] precursor

# Metabolic_Enzyme_1_Synonyms:
DPD; DHPDHase; Dihydrouracil dehydrogenase; Dihydrothymine dehydrogenase

# Metabolic_Enzyme_1_Gene_Name:
DPYD

# Metabolic_Enzyme_1_Protein_Sequence:
>Dihydropyrimidine dehydrogenase NADP+ precursor
MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFD
DIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDN
PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPE
KMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDV
VNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQD
QGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVF
IVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWN
EDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGG
DVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGL
KFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMY
GPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDS
GADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSI
ARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTS
IARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYL
KSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQ
NVAFSPLKRSCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCY
MTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLS
VNPVC

# Metabolic_Enzyme_1_Number_of_Residues:
1025

# Metabolic_Enzyme_1_Molecular_Weight:
111375

# Metabolic_Enzyme_1_Theoretical_pI:
7.05

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  disulfide oxidoreductase activity
Function:  dihydroorotate dehydrogenase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-CH group of donors
Function:  oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
Function:  dihydroorotate oxidase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  transporter activity
Function:  electron transporter activity
 ||
>>>
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  pyrimidine base metabolism
Process:  pyrimidine base biosynthesis
Process:  'de novo' pyrimidine base biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  membrane
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil

# Metabolic_Enzyme_1_Pathway:
map00240  Pyrimidine metabolism;
 map00410  beta-Alanine metabolism;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_1_Reaction:
5,6-dihydrouracil + NADP+ = uracil + NADPH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01180:DHO_dh;
PF00037:Fer4;
PF07992:Pyr_redox_2

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.3.1.2

# Metabolic_Enzyme_1_GenBank_ID_Protein:
558305

# Metabolic_Enzyme_1_SwissProt_ID:
DPYD_HUMAN (Q12882)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
DPYD

# Metabolic_Enzyme_1_Geneatlas_id:
DPYD

# Metabolic_Enzyme_1_hgnc_id:
HGNC:3012

# Metabolic_Enzyme_1_PDB_ID:
1GTE

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>3078 bp
ATGGCCCCTGTGCTCAGTAAGGACTCGGCGGACATCGAGAGTATCCTGGCTTTAAATCCT
CGAACACAAACTCATGCAACTCTGTGTTCCACTTCGGCCAAGAAATTAGACAAGAAACAT
TGGAAAAGAAATCCTGATAAGAACTGCTTTAATTGTGAGAAGCTGGAGAATAATTTTGAT
GACATCAAGCACACGACTCTTGGTGAGCGAGGAGCTCTCCGAGAAGCAATGAGATGCCTG
AAATGTGCAGATGCCCCGTGTCAGAAGAGCTGTCCAACTAATCTTGATATTAAATCATTC
ATCACAAGTATTGCAAACAAGAACTATTATGGAGCTGCTAAGATGATATTTTCTGACAAC
CCACTTGGTCTGACTTGTGGAATGGTATGTCCAACCTCTGATCTATGTGTAGGTGGATGC
AATTTATATGCCACTGAAGAGGGACCCATTAATATTGGTGGATTGCAGCAATTTGCTACT
GAGGTATTCAAAGCAATGAGTATCCCACAGATCAGAAATCCTTCGCTGCCTCCCCCAGAA
AAAATGTCTGAAGCCTATTCTGCAAAGATTGCTCTTTTTGGTGCTGGGCCTGCAAGTATA
AGTTGTGCTTCCTTTTTGGCTCGATTGGGGTACTCTGACATCACTATATTTGAAAAACAA
GAATATGTTGGTGGTTTAAGTACTTCTGAAATTCCTCAGTTCCGGCTGCCGTATGATGTA
GTGAATTTTGAGATTGAGCTAATGAAGGACCTTGGTGTAAAGATAATTTGCGGTAAAAGC
CTTTCAGTGAATGAAATGACTCTTAGCACTTTGAAAGAAAAAGGCTACAAAGCTGCTTTC
ATTGGAATAGGTTTGCCAGAACCCAATAAAGATGCCATCTTCCAAGGCCTGACGCAGGAC
CAGGGGTTTTATACATCCAAAGACTTTTTGCCACTTGTAGCCAAAGGCAGTAAAGCAGGA
ATGTGCGCCTGTCACTCTCCATTGCCATCGATACGGGGAGTCGTGATTGTACTTGGAGCT
GGAGACACTGCCTTCGACTGTGCAACATCTGCTCTACGTTGTGGAGCTCGCCGAGTGTTC
ATCGTCTTCAGAAAAGGCTTTGTTAATATAAGAGCTGTCCCTGAGGAGATGGAGCTTGCT
AAGGAAGAAAAGTGTGAATTTCTGCCATTCCTGTCCCCACGGAAGGTTATAGTAAAAGGT
GGGAGAATTGTTGCTATGCAGTTTGTTCGGACAGAGCAAGATGAAACTGGAAAATGGAAT
GAAGATGAAGATCAGATGGTCCATCTGAAAGCCGATGTGGTCATCAGTGCCTTTGGTTCA
GTTCTGAGTGATCCTAAAGTAAAAGAAGCCTTGAGCCCTATAAAATTTAACAGATGGGGT
CTCCCAGAAGTAGATCCAGAAACTATGCAAACTAGTGAAGCATGGGTATTTGCAGGTGGT
GATGTCGTTGGTTTGGCTAACACTACAGTGGAATCGGTGAATGATGGAAAGCAAGCTTCT
TGGTACATTCACAAATACGTACAGTCACAATATGGAGCTTCCGTTTCTGCCAAGCCTGAA
CTACCCCTCTTTTACACTCCTATTGATCTGGTGGACATTAGTGTAGAAATGGCCGGATTG
AAGTTTATAAATCCTTTTGGTCTTGCTAGCGCAACTCCAGCCACCAGCACATCAATGATT
CGAAGAGCTTTTGAAGCTGGATGGGGTTTTGCCCTCACCAAAACTTTCTCTCTTGATAAG
GACATTGTGACAAATGTTTCCCCCAGAATCATCCGGGGAACCACCTCTGGCCCCATGTAT
GGCCCTGGACAAAGCTCCTTTCTGAATATTGAGCTCATCAGTGAGAAAACGGCTGCATAT
TGGTGTCAAAGTGTCACTGAACTAAAGGCTGACTTCCCAGACAACATTGTGATTGCTAGC
ATTATGTGCAGTTACAATAAAAATGACTGGACGGAACTTGCCAAGAAGTCTGAGGATTCT
GGAGCAGATGCCCTGGAGTTAAATTTATCATGTCCACATGGCATGGGAGAAAGAGGAATG
GGCCTGGCCTGTGGGCAGGATCCAGAGCTGGTGCGGAACATCTGCCGCTGGGTTAGGCAA
GCTGTTCAGATTCCTTTTTTTGCCAAGCTGACCCCAAATGTCACTGATATTGTGAGCATC
GCAAGAGCTGCAAAGGAAGGTGGTGCCAATGGCGTTACAGCCACCAACACTGTCTCAGGT
CTGATGGGATTAAAATCTGATGGCACACCTTGGCCAGCAGTGGGGATTGCAAAGCGAACT
ACATATGGAGGAGTGTCTGGGACAGCAATCAGACCTATTGCTTTGAGAGCTGTGACCTCC
ATTGCTCGTGCTCTGCCTGGATTTCCCATTTTGGCTACTGGTGGAATTGACTCTGCTGAA
AGTGGTCTTCAGTTTCTCCATAGTGGTGCTTCCGTCCTCCAGGTATGCAGTGCCATTCAG
AATCAGGATTTCACTGTGATCGAAGACTACTGCACTGGCCTCAAAGCCCTGCTTTATCTG
AAAAGCATTGAAGAACTACAAGACTGGGATGGACAGAGTCCAGCTACTGTGAGTCACCAG
AAAGGGAAACCAGTTCCACGTATAGCTGAACTCATGGACAAGAAACTGCCAAGTTTTGGA
CCTTATCTGGAACAGCGCAAGAAAATCATAGCAGAAAACAAGATTAGACTGAAAGAACAA
AATGTAGCTTTTTCACCACTTAAGAGAAGCTGTTTTATCCCCAAAAGGCCTATTCCTACC
ATCAAGGATGTAATAGGAAAAGCACTGCAGTACCTTGGAACATTTGGTGAATTGAGCAAC
GTAGAGCAAGTTGTGGCTATGATTGATGAAGAAATGTGTATCAACTGTGGTAAATGCTAC
ATGACCTGTAATGATTCTGGCTACCAGGCTATACAGTTTGATCCAGAAACCCACCTGCCC
ACCATAACCGACACTTGTACAGGCTGTACTCTGTGTCTCAGTGTTTGCCCTATTGTCGAC
TGCATCAAAATGGTTTCCAGGACAACACCTTATGAACCAAAGAGAGGCGTACCCTTATCT
GTGAATCCGGTGTGTTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U09178

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_1_Locus:
1p22

# Metabolic_Enzyme_1_SNPs:
rs1801159; rs1801265; rs2297595; rs1801158; rs1801160; rs17376848; rs6670886; rs291593; rs1042482; rs291592; rs17470762; rs2786770; rs1556798; rs1760215; rs1520658; rs1889229; rs1974203; rs1337752; rs1333717; rs290853; rs2811186; rs2811218; rs1760217; rs2811184; rs828054; rs2027250; rs1931066; rs1556796; rs2811196; rs993714; rs1399285; rs2027056; rs2056048; rs1556795; rs1709409; rs1514494; rs2786775; rs1931063; rs1034217; rs290852; rs828052; rs576189; rs2786512; rs2039448; rs2811173; rs2105129; rs2811219; rs2786778; rs2811185; rs1974204; rs828053; rs2811182; rs1023245; rs1760209; rs494271; rs2786771; rs2297779; rs290855; rs1413235; rs666924; rs2786781; rs2056047; rs868184; rs865242; rs2811198; rs290807; rs11165784; rs1000391; rs4246515; rs6677502; rs4421623; rs495257; rs4582836; rs6697132; rs7531138; rs11165867; rs11799494; rs1413239; rs10875049; rs2811193; rs11165924; rs2811164; rs4970720; rs10493893; rs11165800; rs7526108; rs6681958; rs2039447; rs4554755; rs10875100; rs6670102; rs10157611; rs6671771; rs4304627; rs914959; rs6668296; rs6700670; rs7522938; rs1402258; rs2786518; rs2786776; rs11811087; rs6661442; rs1415681; rs533365; rs11165869; rs1112314; rs652246; rs2297780; rs11165875; rs11165804; rs1879375; rs3897933; rs6663357; rs6593635; rs628959; rs6692658; rs10875084; rs4128473; rs10875098; rs12119089; rs6668653; rs10875051; rs11165791; rs10430074; rs7519652; rs1333721; rs10875090; rs11165846; rs4451581; rs1514499; rs4379706; rs2786505; rs10875076; rs12564011; rs4970721; rs10747491; rs1413227; rs2137975; rs11165886; rs7516492; rs7539889; rs7541618; rs1023244; rs12122032; rs6675325; rs4949955; rs1931064; rs6663670; rs7555294; rs7548189; rs2811212; rs4523551; rs7537165; rs4353133; rs12039249; rs2786507; rs499009; rs526645; rs2811199; rs2248658; rs7412142; rs11165895; rs6665429; rs7512910; rs10875102; rs1413232; rs4495747; rs7527030; rs1538176; rs4970728; rs10875094; rs6700063; rs4950032; rs4319377; rs6604874; rs10747487; rs6700981; rs950467; rs6674636; rs1520664; rs1413231; rs4970716; rs528455; rs2811190; rs7525018; rs952856; rs4264037; rs7533902; rs10493894; rs827497; rs2786519; rs290851; rs7527272; rs7535694; rs991544; rs1337522; rs2811221; rs6593640; rs7540201; rs11165789; rs6667364; rs2027054; rs10518636; rs1999571; rs1890138; rs6593641; rs10783056; rs4503384; rs7520102; rs6687374; rs2027057; rs11165823; rs2811211; rs10875105; rs4950031; rs4300257; rs6656660; rs2811167; rs13375516; rs1556794; rs4497250; rs866129; rs4950025; rs1556797; rs970337; rs507170; rs2151563; rs7538155; rs4970723; rs4520446; rs1337521; rs4949952; rs552926; rs4970719; rs2811220; rs4537601; rs7552825; rs6593642; rs945879; rs667565; rs1333727; rs6593634; rs638456; rs1034215; rs2786494; rs6604094; rs9661794; rs11165922; rs2151567; rs6686861; rs11811436; rs1607778; rs11165783; rs4372296; rs10875085; rs519852; rs6668057; rs12566907; rs6593638; rs10875053; rs7523609; rs2786785; rs10783057; rs12568621; rs10735793; rs4511173; rs4390222; rs6681752; rs4950021; rs2786500; rs12030174; rs11165827; rs5027693; rs2786529; rs7517899; rs17100624; rs17378455; rs10518643; rs2786496; rs864341; rs1034216; rs6698780; rs6689930; rs12120077; rs4412640; rs2786509; rs12411169; rs17471640; rs12074083; rs9782950; rs4415625; rs10493895; rs2225882; rs12062845; rs10747486; rs17116810; rs10875118; rs11165923; rs10875055; rs17379561; rs10875075; rs17116566; rs4950041; rs4950033; rs2786543; rs993568; rs11165815; rs9727976; rs17369442; rs2811179; rs11165861; rs7530858; rs12402250; rs11808108; rs4546957; rs6672633; rs12040763; rs7538995; rs12024830; rs1413241; rs6685859; rs6604095; rs4414075; rs11165793; rs885622; rs17116720; rs10875069; rs10875073; rs17116602; rs12126093; rs17702702; rs11800171; rs4950023; rs11810136; rs10875113; rs955850; rs6667550; rs11165883; rs2786539; rs4394693; rs10783063; rs1333719; rs11165837; rs1577897; rs12073839; rs563832; rs12061124; rs4367807; rs12081472; rs17116539; rs10875056; rs1879373; rs6692424; rs4949947; rs7527085; rs10747488; rs10518637; rs644023; rs12729863; rs2151562; rs828059; rs12123121; rs4360558; rs12048767; rs2786498; rs2786490; rs17116531; rs11811238; rs7512040; rs17116806; rs11165921; rs652247; rs12021567; rs7518848; rs7519112; rs2811169; rs1413234; rs11805672; rs952501; rs10747484; rs11165845; rs2786514; rs10875071; rs4949953; rs17379095; rs914956; rs12047910; rs10875058; rs4589145; rs1538120; rs2152878; rs6683957; rs12063030; rs4950026; rs12124566; rs7517433; rs592609; rs12140120; rs1879371; rs2811202; rs6699630; rs2811194; rs17117003; rs2811171; rs1514496; rs11165873; rs12116905; rs2130365; rs11165798; rs693680; rs7554586; rs7522200; rs6678858; rs2811183; rs10783066; rs11165881; rs3790384; rs10875045; rs954923; rs1415682; rs11165864; rs7528359; rs2811209; rs17377638; rs2811177; rs1520660; rs12127420; rs1399291; rs11165870; rs493517; rs1577895; rs641805; rs3897854; rs12136186; rs9662870; rs12093067; rs4949958; rs676686; rs595937; rs1413229; rs10875109; rs6604092; rs9661407; rs6672867; rs6692580; rs2811205; rs6700920; rs6593647; rs10493892; rs2811187; rs2065943; rs1879374; rs11165814; rs6593633; rs1915313; rs11582955; rs945881; rs7544742; rs1000392; rs471581; rs12062552; rs12130586; rs2811215; rs3790389; rs2811192; rs17116766; rs10783069; rs6703307; rs1760212; rs553388; rs13376217; rs2786533; rs11165889; rs12407793; rs2811208; rs12735722; rs16798; rs10783058; rs2786773; rs1520663; rs10493890; rs2786782; rs11165874; rs12563828; rs7523632; rs6682836; rs10157665; rs3762412; rs6676451; rs10493896; rs2786538; rs4246514; rs11582179; rs1356919; rs4394694; rs12024396; rs2786525; rs1333718; rs2786522; rs12023630; rs10747482; rs11799399; rs644428; rs7530072; rs10747492; rs10875057; rs7521383; rs10875061; rs4492658; rs12129287; rs4128472; rs8179310; rs11165902; rs12406000; rs7540983; rs6681743; rs4304628; rs1931071; rs2811174; rs11165792; rs11589238; rs6677116; rs12407440; rs11165794; rs2786503; rs2811162; rs12022771; rs7544128; rs11165799; rs12031561; rs12059052; rs10875048; rs7513333; rs10875046; rs2780851; rs1415683; rs2056049; rs2811168; rs12041436; rs11165830; rs11812084; rs6604119; rs2811200; rs12119882; rs9437663; rs867261; rs7526691; rs11165863; rs11806109; rs6664888; rs2786537; rs2786504; rs6683351; rs11578795; rs11802430; rs7545712; rs10783065; rs7556439; rs7537668; rs11587873; rs10875077; rs11165877; rs6593636; rs9662719; rs864335; rs11165856; rs11588048; rs1014320; rs11805694; rs2095686; rs7524038; rs7516781; rs17116469; rs10875112; rs11165829; rs17116860; rs11165797; rs2027055; rs950754; rs496179; rs1520668; rs10875050; rs11165779; rs10875074; rs10875064; rs10047165; rs828058; rs2090763; rs12568335; rs10747485; rs7516433; rs10875062; rs1514497; rs6696033; rs10465748; rs4348763; rs12097618; rs2811165; rs11165908; rs1609519; rs11165855; rs11165887; rs2811203; rs1879372; rs2184191; rs9725545; rs11165879; rs2811170; rs12040388; rs7545340; rs2811195; rs10875099; rs1337523; rs1514495; rs6685976; rs12354219; rs7550959; rs12566576; rs6697058; rs17117234; rs7523116; rs1399290; rs11165880; rs1333722; rs6593639; rs6684683; rs11165888; rs3897932; rs7549522; rs11810126; rs7549384; rs12134028; rs12081878; rs2786530; rs7521757; rs12032158; rs12567359; rs12022243; rs12089031; rs12044858; rs2018605; rs10875111; rs12760992; rs4970717; rs10875060; rs2485436; rs4950028; rs6593650; rs11580981; rs2811204; rs11806147; rs12752069; rs12746909; rs17370884; rs6593646; rs12759852; rs12073005; rs17117211; rs1413224; rs2811161; rs17117281; rs12565248; rs828057; rs2811214; rs12129397; rs11799497; rs11165802; rs4266934; rs7522113; rs542490; rs10465760; rs6701415; rs12090036; rs17116502; rs12048428; rs7531100; rs12086529; rs12029106; rs12731506; rs17116925; rs7528631; rs17117194; rs12084600; rs7547060; rs6682669; rs945880; rs12133566; rs2786540; rs12564608; rs10783076; rs4434871; rs6663628; rs10783060; rs17377919; rs2811213; rs12025602; rs2991263; rs4949949; rs12066229; rs10783055; rs7524812; rs17378539; rs7418577; rs6702893; rs6702924; rs2811216; rs1931072; rs2152877; rs6661380; rs11165822; rs2786783; rs12034649; rs10875089; rs2786502; rs17117037; rs17116439; rs17116909; rs12030316; rs17117251; rs7520949; rs2811163; rs10875106; rs6593649; rs10875070; rs11165891; rs6593648; rs17116962; rs7549538; rs13375850; rs11809950; rs2811210; rs17431828; rs12063370; rs3790387; rs17116452; rs7527411; rs4949950; rs10875095; rs10458511; rs7542014; rs12060037; rs7554746; rs2811191; rs10747483; rs12043044; rs10875080; rs12139650; rs17117198; rs12127542; rs4950037; rs12059591; rs12060207; rs12725266; rs11165926; rs17117179; rs11165835; rs11165903; rs9725575; rs12094393; rs6690620; rs12063966; rs11801171; rs12123145; rs17116821; rs7529372; rs4970727; rs12048063; rs4950035; rs12073650; rs12564297; rs12124552; rs17471125; rs6682655; rs7528037; rs12091654; rs290850; rs7512213; rs6691128; rs17369919; rs2786497; rs12048612; rs13373839; rs4399192; rs7536690; rs1399287; rs7545029; rs17117181; rs12079743; rs12047625; rs7511709; rs7514826; rs1040090; rs914937; rs2786777; rs4266922; rs6664275; rs11165884; rs12043021; rs6604093; rs6686280; rs2039449; rs12568733; rs7556387; rs11799304; rs17117062; rs1356917; rs563033; rs10875052; rs12046744; rs2811201; rs12048663; rs6683883; rs505864; rs5027690; rs2786780; rs6698789; rs11589971; rs12403187; rs7537094; rs17117169; rs12079660; rs17471577; rs7554113; rs10449723; rs11165917; rs12060434; rs4612663; rs7544620; rs17117173; rs10735795; rs11165862; rs12758854; rs11165786; rs17117203; rs12094181; rs7550523; rs6656968; rs7414298; rs6703589; rs12756513; rs17368985; rs11586728; rs12022799; rs12731707; rs11590802; rs6686712; rs11588242; rs10875047; rs4949945; rs6693628; rs12091152; rs1413230; rs6593631; rs1399289; rs6676635; rs6593637; rs12401348; rs17117162; rs12128564; rs2786532; rs17117052; rs11165810; rs7546038; rs2786526; rs12121057; rs17117159; rs7543523; rs2811188; rs3897855; rs4497251; rs17116518; rs2786772; rs6684671; rs17117175; rs11165831; rs885086; rs17378671; rs12077442; rs12354275; rs10465749; rs6688509; rs12081900; rs7411676; rs2811181; rs12032276; rs12740796; rs1889228; rs7521567; rs4970715; rs6685266; rs11165857; rs6689552; rs12047072; rs4950042; rs17117116; rs11578528; rs7529624; rs12096383; rs10747494; rs12403912; rs2811178; rs4950030; rs12086531; rs1013810; rs12137174; rs9727974; rs6593643; rs12035560; rs12080739; rs4950040; rs12406752; rs2811166; rs1333728; rs6692877; rs827500; rs4350235; rs11165826; rs28595744; rs9324374; rs3920740; rs10783070; rs7527288; rs6674158; rs10218636; rs7551099; rs11165807; rs4351704; rs12028211; rs2786521; rs11165788; rs6696976; rs12409761; rs6667128; rs6604873; rs12049622; rs4290093; rs983101; rs6656329; rs10875119; rs12117481; rs17100628; rs2786508; rs9727548; rs11165925; rs17116479; rs9783115; rs12408270; rs10458510; rs12082644; rs6691764; rs7535930; rs6693964; rs2391822; rs10783062; rs12026902; rs12072735; rs17116465; rs11165882; rs12043043; rs11805551; rs2049110; rs7539477; rs12082185; rs11165832; rs6701322; rs7552188; rs2786542; rs2786769; rs11165860; rs1889230; rs828061; rs6692785; rs6421757; rs10783068; rs17117249; rs2786491; rs7540621; rs17116398; rs6692946; rs7521671; rs7515904; rs290808; rs11165912; rs2171826; rs12410949; rs12069661; rs7518354; rs2095663; rs1810252; rs11165781; rs2786501; rs12035468; rs12060391; rs4445510; rs11165900; rs11804848; rs12093238; rs7512357; rs4364915; rs2039676; rs12120068; rs7414210; rs12120388; rs6681394; rs290849; rs11165897; rs6593630; rs12563974; rs3120632; rs17116410; rs12043040; rs12139338; rs12043125; rs6680180; rs12407539; rs11165838; rs12753487; rs10783077; rs7527309; rs17368837; rs12735738; rs6685658; rs11165866; rs12073044; rs13376084; rs4634942; rs12122798; rs11588741; rs17116476; rs11812070; rs12137711; rs12126850; rs4949951; rs1970143; rs1889227; rs6680642; rs11165805; rs11584924; rs17117112; rs828060; rs7514861; rs828063; rs12082798; rs7555984; rs12064659; rs12023626; rs2786536; rs10747489; rs17117167; rs7521352; rs7521541; rs11165834; rs11583545; rs6691565; rs12406631; rs6690403; rs2786541; rs17116940; rs9969993; rs290806; rs17117214; rs12033263; rs1760210; rs2786531; rs7546862; rs12144395; rs12141657; rs12046655; rs12136135; rs17117207; rs12026223; rs17116416; rs10747490; rs17116462; rs4970718; rs12081166; rs4427441; rs10875078; rs12087910; rs640711; rs12062102; rs10875088; rs4428925; rs828055; rs11165899; rs10875086; rs11165803; rs7543614; rs12740800; rs12403515; rs12133667; rs6672095; rs10465747; rs7545622; rs11811222; rs17116488; rs17117222; rs6660936; rs1413228; rs1963206; rs17116594; rs12402646; rs4385755; rs1333720; rs12086001; rs12032384; rs11165844; rs12074030; rs4949954; rs12124488; rs6690447; rs4329543; rs11165868; rs10875103; rs11165836; rs7544948; rs10875059; rs2811197; rs1577896; rs11587447; rs13375275; rs12040045; rs2786535; rs7526933; rs11582587; rs12725934; rs12119333; rs12076846; rs7537617; rs17116854; rs1812389; rs12134860; rs12068789; rs11165780; rs6658412; rs10875108; rs1931065; rs12735808; rs12759539; rs12726453; rs12066847; rs17116920; rs1117019; rs17116357; rs2018902; rs2811217; rs12040699; rs10127817; rs10158174; rs17116458; rs12092177; rs2811176; rs17117118; rs10875079; rs2068642; rs1399288; rs17117228; rs12565244; rs12125423; rs10875097; rs10875087; rs2786499; rs12144462; rs11165850; rs993921; rs12406713; rs7554218; rs11165920; rs11165790; rs12403997; rs9659958; rs4523552; rs6700957; rs17116506; rs17116509; rs28483122; rs1610253; rs6672654; rs12028565; rs12038518; rs7531326; rs12046771; rs10875091; rs2786506; rs6695791; rs11165865; rs2786513; rs12057205; rs9651211; rs12048413; rs12119381; rs6676351; rs12565467; rs7523775; rs11582736; rs12133176; rs10783059; rs12407546; rs12564345; rs2786544; rs12063497; rs10875092; rs12122422; rs6679142; rs12405810; rs6657204; rs7412024; rs689001; rs12089969; rs1413233; rs4319378; rs2786527; rs6676624; rs6690816; rs2811206; rs12739159; rs12068454; rs11583737; rs2786784; rs6679536; rs17432093; rs4970722; rs17117218; rs7545506; rs17117176; rs12059341; rs12040478; rs17117092; rs2786774; rs6593632; rs12047563; rs7525922; rs12567477; rs12045999; rs7553943; rs17117236; rs1855376; rs11165872; rs9727008; rs11580977; rs17432999; rs4950038; rs12093651; rs12094781; rs7521537; rs12125127; rs12039093; rs12047456; rs7531819; rs290861; rs158634; rs291550; rs17430460; rs6604096; rs1801267; rs1801266; rs1801268; rs3918289; rs6675198; rs1042478; rs1042479; rs3918290; rs34856860; rs1042481; rs41285690; rs1042480; rs2635723; rs34749842; rs28711209; rs4285753; rs35346681; rs4350236; rs28468570; rs1976175; rs28390368; rs12749253; rs12741091; rs12074340; rs11165849; rs35669577; rs5026209; rs35127872; rs11305940; rs36051564; rs12032753; rs34467104; rs35113568; rs5776346; rs12748804; rs33967766; rs7543832; rs11329199; rs34003262; rs9701777; rs36060250; rs3075432; rs9728815; rs5018206; rs35514561; rs35010383; rs12726496; rs34693701; rs3050245; rs4457618; rs35425120; rs36118685; rs11329805; rs3075442; rs12759500; rs35214370; rs10595002; rs12097480; rs34165549; rs34535802; rs12082772; rs34765667; rs35741625; rs10158970; rs7414112; rs11392740; rs12723967; rs828056; rs5776386; rs12746260; rs35040585; rs28755414; rs1015828; rs34965803; rs5776388; rs12072437; rs34433374; rs12745877; rs28699374; rs35005021; rs5776365; rs12093539; rs35192169; rs7543510; rs2780852; rs12092946; rs10449720; rs11350065; rs12089025; rs28422942; rs10783061; rs2256807; rs12142437; rs7512345; rs35583828; rs12736528; rs12066470; rs12083975; rs4638160; rs2786520; rs10615198; rs4411156; rs7521763; rs12754025; rs35538411; rs1356918; rs5776360; rs10875093; rs11432017; rs34586145; rs34541619; rs12567802; rs1855363; rs12116548; rs6689341; rs34145094; rs12081421; rs35173224; rs35656329; rs7547835; rs11366600; rs12033002; rs7415016; rs2811172; rs2222327; rs5027691; rs28514964; rs11582635; rs12091767; rs10783067; rs28880911; rs34314829; rs35183951; rs35854736; rs34602285; rs9727438; rs28552528; rs6682855; rs1958946; rs12752059; rs35025181; rs34091738; rs34894805; rs34185079; rs12755039; rs7538663; rs2786492; rs28829687; rs12078571; rs35863255; rs12041525; rs34113502; rs4504944; rs28615803; rs12030189; rs1413237; rs35330951; rs5776363; rs28755787; rs6687856; rs10606435; rs11338222; rs12141326; rs36076494; rs28478258; rs35515993; rs7517110; rs12136315; rs11165782; rs34754374; rs4565769; rs1970142; rs3765175; rs12134522; rs12029380; rs34380072; rs34875839; rs10674615; rs35316575; rs11404497; rs12089260; rs34047559; rs11801116; rs12737967; rs35717955; rs35151553; rs36153065; rs34486662; rs7519351; rs36074078; rs12138677; rs35967105; rs6669422; rs11382165; rs34683254; rs28538108; rs17116413; rs34791837; rs6663751; rs5776344; rs12057755; rs35605856; rs12024103; rs12140043; rs35905725; rs1856159; rs7524482; rs10157336; rs6676657; rs35413950; rs12095939; rs36194219; rs11801312; rs34463725; rs4495745; rs34613852; rs1798737; rs35441721; rs12073487; rs5776353; rs35924442; rs7539913; rs35398836; rs35459584; rs35970691; rs12029826; rs12745512; rs5776371; rs5776362; rs11582697; rs34087876; rs34267648; rs34328197; rs827498; rs12071499; rs35720876; rs35963307; rs35581369; rs34057124; rs5776356; rs34031151; rs34806595; rs7513650; rs11275458; rs10671966; rs28556633; rs12739046; rs13376487; rs12731376; rs34338692; rs35506398; rs34683131; rs9629025; rs12742215; rs12121789; rs2786524; rs28830194; rs35038074; rs12070513; rs36103731; rs2786523; rs12043033; rs12403951; rs5027664; rs7547044; rs28655439; rs12034568; rs12072104; rs35282661; rs472777; rs12031326; rs35531075; rs35764066; rs1984091; rs12022140; rs10637837; rs34445661; rs12022983; rs35975305; rs12137205; rs7513298; rs34054873; rs35415616; rs7530645; rs4970724; rs12756004; rs12119653; rs12759823; rs35692930; rs34379051; rs11165913; rs5776378; rs2151560; rs12746053; rs35752036; rs28671479; rs11589300; rs35568022; rs34528376; rs10677535; rs36025579; rs34654520; rs11430221; rs8179344; rs34950626; rs35933841; rs7553888; rs33972983; rs12071429; rs35566734; rs35893611; rs35613600; rs35692540; rs10591961; rs7553077; rs6143333; rs12729191; rs34452925; rs35684876; rs7552708; rs34830547; rs3790385; rs3862912; rs12567804; rs35146139; rs11165914; rs34671804; rs12066332; rs12086534; rs12090721; rs34765055; rs35253410; rs28613692; rs7516576; rs17377093; rs35308807; rs35339301; rs12088402; rs34563253; rs12134462; rs34305248; rs12040059; rs11165777; rs12727481; rs28558822; rs12738892; rs12064815; rs2811175; rs12044501; rs1607779; rs12143861; rs17116957; rs34747848; rs4285754; rs35469949; rs35693384; rs12041906; rs7411982; rs4558029; rs34985601; rs11165828; rs6681582; rs34678676; rs34960511; rs10567915; rs36000256; rs6679873; rs1760219; rs34192622; rs34311587; rs34454297; rs12061986; rs6689296; rs5029789; rs17117078; rs34215854; rs12076346; rs12184251; rs36090056; rs34738275; rs34686468; rs35406401; rs12093470; rs290854; rs41300337; rs36011197; rs34447969; rs9727787; rs6699098; rs28408889; rs35298859; rs35593702; rs11300172; rs34776985; rs12750553; rs11445699; rs9728796; rs571444; rs17116949; rs1360675; rs35163134; rs36017006; rs11165893; rs12730080; rs35900828; rs12758423; rs10702051; rs35825151; rs11586231; rs12071081; rs1212191; rs28526496; rs5776364; rs12126921; rs35271365; rs12044876; rs6666129; rs34098309; rs12087430; rs35463548; rs12038195; rs7418580; rs35643569; rs5776369; rs12074451; rs34535138; rs36040504; rs2786534; rs12408135; rs6667213; rs29001643; rs12034670; rs34055744; rs34380136; rs34198280; rs35054503; rs7515966; rs35687782; rs1113699; rs10672791; rs34460898; rs4351706; rs34387885; rs35767735; rs36037675; rs11310786; rs12137247; rs6663414; rs28452204; rs34853678; rs36060421; rs4615876; rs10631564; rs35274548; rs11576351; rs6665022; rs12026229; rs12024715; rs12032674; rs5776359; rs4431878; rs12757590; rs5776358; rs17370607; rs36108874; rs2203981; rs34346385; rs12758055; rs11349223; rs868185; rs35824060; rs36024354; rs1040091; rs34523862; rs11808750; rs28629820; rs12044783; rs12731596; rs12731834; rs12065693; rs35541962; rs34911421; rs7411984; rs35419371; rs11334243; rs17377142; rs28423050; rs4146964; rs6687950; rs11422049; rs12026200; rs12568554; rs1599778; rs12023030; rs10875054; rs28532649; rs34891420; rs4579796; rs12139679; rs36089455; rs35671365; rs12750100; rs34258528; rs10601085; rs12145481; rs11165854; rs11165928; rs10591187; rs12744789; rs13374282; rs34519857; rs7524759; rs12093707; rs35422302; rs5776384; rs36028550; rs9725886; rs35627404; rs1855378; rs12735483; rs35155457; rs34601540; rs4128720; rs13375858; rs2811207; rs35544114; rs4375301; rs13375021; rs34455783; rs12738234; rs12047930; rs34580383; rs12043147; rs12145460; rs36061783; rs34823012; rs673989; rs34290889; rs34553460; rs35189712; rs6143335; rs12753135; rs34011849; rs34224428; rs35050339; rs34390188; rs5776348; rs35495081; rs12724889; rs35346742; rs12029801; rs12141897; rs35432274; rs12048947; rs34312119; rs4445524; rs1402256; rs3921368; rs11414362; rs2485437; rs34034090; rs10651231; rs12081769; rs12058656; rs10622783; rs36025346; rs34270736; rs36081268; rs34150735; rs10449721; rs7526790; rs12042544; rs35864097; rs35707097; rs2786510; rs10616443; rs12043234; rs11165919; rs4428924; rs35605550; rs2786493; rs4570451; rs10545599; rs41313397; rs28627833; rs34653351; rs11165851; rs1337750; rs12726192; rs17599509; rs2786528; rs36024641; rs13376369; rs1514498; rs12727629; rs12136249; rs34547572; rs12041802; rs10565495; rs12408678; rs17117047; rs11286049; rs12725967; rs28696953; rs10617327; rs12749890; rs34844802; rs35635672; rs1709411; rs34428152; rs11366169; rs12128363; rs34774035; rs35453402; rs12751479; rs10158124; rs5027688; rs17116954; rs35422608; rs28514726; rs11428644; rs35471205; rs11333229; rs828062; rs35046170; rs34985058; rs35688762; rs11165909; rs2151564; rs34932777; rs1538175; rs12760243; rs12046043; rs17117044; rs10158132; rs35002871; rs34931312; rs35589952; rs35558163; rs35263335; rs34817211; rs6675639; rs35614335; rs34044808; rs12749862; rs11457319; rs35044029; rs36058943; rs6682166; rs12034814; rs827499; rs12097874; rs34788656; rs12131043; rs36148675; rs28455005; rs5776366; rs3050227; rs12756826; rs12070583; rs7410810; rs12402535; rs11165852; rs35210810; rs12047716; rs7411713; rs12023004; rs4336888; rs35675942; rs35131461; rs35608307; rs2151561; rs12030332; rs1984090; rs35220719; rs12751069; rs10625722; rs6674056; rs35309171; rs35070715; rs6678229; rs993569; rs34798489; rs10610591; rs35011266; rs6703357; rs34277796; rs11375210; rs34606787; rs34267374; rs28714464; rs12144123; rs12072154; rs28589864; rs35013990; rs4489611; rs34902826; rs12025217; rs5776387; rs35739503; rs34933007; rs12727975; rs10572395; rs12726516; rs12736531; rs35454049; rs34997220; rs12049600; rs35459236; rs35685115; rs34534958; rs34267012; rs35677459; rs35182755; rs12069330; rs7413448; rs34884630; rs17377205; rs7412430; rs35505267; rs2786511; rs34898972; rs12754968; rs12024083; rs34833945; rs35847147; rs7536770; rs10647561; rs1337751; rs5776385; rs34521601; rs11165894; rs34998323; rs12743854; rs12060079; rs35562854; rs10657499; rs35792674; rs5776352; rs35564684; rs12096724; rs9324375; rs4950029; rs34973099; rs34934403; rs12137138; rs12071338; rs2786495; rs12726688; rs9970119; rs12749069; rs11400594; rs34856977; rs34441398; rs12120514; rs4309016; rs12044838; rs34749427; rs12037001; rs11457298; rs11345923; rs2893373; rs6694335; rs35927808; rs3050223; rs35302041; rs4492671; rs34870370; rs34389018; rs12039808; rs35940342; rs35926262; rs35829715; rs12024660; rs4309030; rs4381229; rs12750717; rs12132383; rs12030792; rs34357448; rs34286411; rs28371444; rs34634453; rs7413375; rs35099417; rs28889402; rs2184969; rs12750549; rs34953224; rs34448971; rs34260541; rs3899778; rs7534056; rs34756596; rs5776377; rs35444260; rs35331418; rs7533929; rs601149; rs12032698; rs12027034; rs12058898; rs12139110; rs34230085; rs35815272; rs12739965; rs28692740; rs11165927; rs11165905; rs35322606; rs36134825; rs4514272; rs33986674; rs1589344; rs7513888; rs12043951; rs13376404; rs17116923; rs7543999; rs28436624; rs12138657; rs7411549; rs28848627; rs35251009; rs2210616; rs34146034; rs10666387; rs1589342; rs12075750; rs4950034; rs4408184; rs7548444; rs12750322; rs12064809; rs35491393; rs5776379; rs34244040; rs12067602; rs35506209; rs35658487; rs12024658; rs36173435; rs28623242; rs4543837; rs35399577; rs34892116; rs11165876; rs34843163; rs2049112; rs34606545; rs34002532; rs35302625; rs5776357; rs12760860; rs12024690; rs5776380; rs34736058; rs12406531; rs35699704; rs4259713; rs12750443; rs12048588; rs35060117; rs35671414; rs10689805; rs12094465; rs34230880; rs12742911; rs35378905; rs3790388; rs3956688; rs35222149; rs34650886; rs28552810; rs1413236; rs12739758; rs10783075; rs34169534; rs35212725; rs34719218; rs35923854; rs35301486; rs33994522; rs2786517; rs6604118; rs6656043; rs12032746; rs12027570; rs35856817; rs10158390; rs12734780; rs28457754; rs6702673; rs35402669; rs17116564; rs10558704; rs4572003; rs12072522; rs34631796; rs12735471; rs35441763; rs35686429; rs28490531; rs12022669; rs28428772; rs34338799; rs1856158; rs5015353; rs5776345; rs35477668; rs34405549; rs10430076; rs35488985; rs34146407; rs6693034; rs10430075; rs35371362; rs17369773; rs12032827; rs34638169; rs35748881; rs10642839; rs28590328; rs12045127; rs12744161; rs12410240; rs35504747; rs34806815; rs34084132; rs36042282; rs12750863; rs6683233; rs12138709; rs34773620; rs12046864; rs34210396; rs34000126; rs35063793; rs5776347; rs10157396; rs2786516; rs34394222; rs12406052; rs6666920; rs35216070; rs34698824; rs10157130; rs35786435; rs12741841; rs10564140; rs2786515; rs34213322; rs12096100; rs12751038; rs12091480; rs34250792; rs35947403; rs34486749; rs33998382; rs34397017; rs4363450; rs12408679; rs12047569; rs12072739; rs35694562; rs12093141; rs35181732; rs1970141; rs34401391; rs12090947; rs6674116; rs6678008; rs35856948; rs2152879; rs9727803; rs12024708; rs12745124; rs12042394; rs12133824; rs12086537; rs628816; rs4949944; rs36087444; rs885621; rs12727657; rs34992328; rs3075433; rs34096860; rs35012523; rs11408866; rs36005573; rs12080469; rs11343500; rs12035814; rs34407579; rs12144202; rs11165907; rs34583509; rs34002705; rs11165808; rs12749836; rs35475712; rs28363717; rs12567803; rs12032933; rs5015354; rs34863394; rs34704297; rs12751902; rs12091552; rs6673282; rs10719278; rs34085458; rs1931062; rs34457110; rs12410593; rs4128474; rs34092675; rs12048941; rs35732009; rs12125748; rs35070194; rs34516612; rs1399286; rs12758564; rs35729111; rs7528701; rs11442543; rs11337033; rs12036730; rs34511350; rs28503944; rs12043428; rs34132621; rs3790386; rs3050226; rs35417363; rs35740888; rs35592236; rs12042451; rs844144; rs10593660; rs35045109; rs12135891; rs34961061; rs35061265; rs35805795; rs2786489; rs35294947; rs34934786; rs34588073; rs11165915; rs12728798; rs5776361; rs11423158; rs688913; rs4604729; rs11374387; rs1589343; rs12727631; rs11406485; rs6143334; rs17368930; rs35600758; rs35728010; rs34833638; rs34754839; rs12029685; rs10218605; rs6657627; rs35795641; rs11584267; rs12022341; rs5776343; rs4112180; rs3790383; rs35169685; rs12727612; rs10449722; rs34186134; rs12738091; rs6676439; rs10607579; rs35748583; rs34699023; rs6670376; rs28619552; rs12077606; rs11165901; rs36082321; rs12091061; rs1212973; rs1413238; rs35742020; rs6661755; rs12045421; rs12750945; rs5776381; rs11165833; rs34993104; rs35349839; rs34513531; rs36079385; rs35917752; rs35946428; rs35738469; rs828051; rs35433813; rs12058771; rs34734647; rs11165918; rs36106303; rs12745144; rs35068907; rs12085788; rs6689165; rs11165806; rs35375213; rs33995723; rs478741; rs34374142; rs10685111; rs34749066; rs6692657; rs35192579; rs34449409; rs35500519; rs34942284; rs11379961; rs4950020; rs12753126; rs34035833; rs34656878; rs1202854; rs34256325; rs12088567; rs35729590; rs12406482; rs35917998; rs6696988; rs35745646; rs4612662; rs10598574; rs12734766; rs35718889; rs12094442; rs12039647; rs35519081; rs11590340; rs12564826; rs12033517; rs1337749; rs34455463; rs34343325; rs7514934; rs34476211; rs12752057; rs12136549; rs12402806; rs7414031; rs34581949; rs12078940; rs35518649; rs5027689; rs12040079; rs12732180; rs2786779; rs34154901; rs35691382; rs13374102; rs6671569; rs5776351; rs11165871; rs34754458; rs12752763; rs2245907; rs35474273; rs35814910; rs12126526; rs35740907; rs35111926; rs4950027; rs34805777; rs34786009; rs11165795; rs35231733; rs12733572; rs12410232; rs35303001; rs34597038; rs12736583; rs10645994; rs6659732; rs11580684; rs1009462; rs5776383; rs10681575; rs11434465; rs10572396; rs28796973; rs34389483; rs34059745; rs41309171; rs6668162; rs34435288; rs650879; rs12076723; rs1212190; rs34940186; rs36122057; rs35877260; rs2203982; rs34437573; rs28571585; rs12043146; rs35804789; rs1855364; rs35519928; rs35920443; rs2811180; rs35619235; rs35850346; rs5776349; rs4269803; rs34399548; rs34858264; rs290862; rs11165775; rs11800908; rs11807548; rs12028914; rs158635; rs17100610; rs1760216; rs290863; rs290865; rs290866; rs290867; rs290868; rs290869; rs35196212; rs4378243; rs4456128; rs7556646

# Metabolic_Enzyme_1_General_References:
8083224; 9135003; 9464498; 8892022; 9170156; 1512248; 9439663; 9266349

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5814

# Metabolic_Enzyme_2_Name:
Dihydropyrimidinase

# Metabolic_Enzyme_2_Synonyms:
DHPase; Hydantoinase; DHP

# Metabolic_Enzyme_2_Gene_Name:
DPYS

# Metabolic_Enzyme_2_Protein_Sequence:
>Dihydropyrimidinase
MAAPSRLLIRGGRVVNDDFSEVADVLVEDGVVRALGHDLLPPGGAPAGLRVLDAAGKLVL
PGGIDTHTHMQFPFMGSRSIDDFHQGTKAALSGGTTMIIDFAIPQKGGSLIEAFETWRSW
ADPKVCCDYSLHVAVTWWSDQVKEEMKILVQDKGVNSFKMFMAYKDLYMVTDLELYEAFS
RCKEIGAIAQVHAENGDLIAEGAKKMLALGITGPEGHELCRPEAVEAEATLRAITIASAV
NCPLYIVHVMSKSAAKVIADARRDGKVVYGEPIAASLGTDGTHYWNKEWHHAAHHVMGPP
LRPDPSTPDFLMNLLANDDLTTTGTDNCTFNTCQKALGKDDFTKIPNGVNGVEDRMSVIW
EKGVHSGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIVIWDPKGTRTISAKTHH
QAVNFNIFEGMVCHGVPLVTISRGKVVYEAGVFSVTAGDGKFIPRKPFAEYIYKRIKQRD
RTCTPTPVERAPYKGEVATLKSRVTKEDATAGTRKQAHP

# Metabolic_Enzyme_2_Number_of_Residues:
519

# Metabolic_Enzyme_2_Molecular_Weight:
56630

# Metabolic_Enzyme_2_Theoretical_pI:
7.28

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
5,6-dihydrouracil + H(2)O = 3- ureidopropanoate

# Metabolic_Enzyme_2_Pathway:
map00240  Pyrimidine metabolism;
 map00410  beta-Alanine metabolism;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_2_Reaction:
5,6-dihydrouracil + H2O = 3-ureidopropanoate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01979:Amidohydro_1

# Metabolic_Enzyme_2_Signals:
1-2

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.5.2.2

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1330236

# Metabolic_Enzyme_2_SwissProt_ID:
DPYS_HUMAN (Q14117)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
DPYS

# Metabolic_Enzyme_2_Geneatlas_id:
DPYS

# Metabolic_Enzyme_2_hgnc_id:
HGNC:3013

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_2_Gene_Sequence:
>1560 bp
ATGGCGGCGCCCTCGCGGCTCCTGATCCGCGGGGGTCGCGTGGTCAACGATGACTTCTCG
GAGGTGGCCGACGTGCTGGTGGAGGACGGCGTGGTGCGGGCACTCGGGCACGACCTGCTG
CCTCCCGGGGGCGCTCCTGCGGGGCTGCGGGTCCTCGACGCCGCCGGCAAGCTCGTCCTG
CCCGGAGGCATCGACACACACACGCACATGCAGTTCCCCTTCATGGGCTCGCGGTCCATC
GACGACTTCCACCAGGGCACCAAGGCTGCTCTCTCAGGAGGCACCACCATGATTATTGAT
TTCGCCATTCCTCAGAAAGGTGGCTCCCTCATTGAGGCCTTCGAGACCTGGCGAAGCTGG
GCTGATCCCAAAGTTTGCTGCGACTACAGCCTTCATGTGGCAGTGACGTGGTGGAGTGAC
CAGGTTAAAGAAGAAATGAAAATCCTTGTGCAAGATAAAGGTGTTAACTCTTTCAAGATG
TTTATGGCCTATAAAGATCTGTACATGGTGACAGACCTGGAGCTGTACGAAGCCTTCTCT
CGGTGCAAGGAAATTGGAGCAATTGCCCAGGTCCATGCGGAAAATGGAGACTTAATTGCA
GAGGGAGCAAAGAAGATGTTGGCTCTGGGGATAACAGGCCCTGAGGGCCACGAGCTGTGC
CGCCCAGAGGCAGTGGAGGCAGAGGCCACGCTGAGAGCCATCACCATAGCCAGCGCTGTG
AACTGTCCTCTCTACATTGTGCATGTGATGAGCAAGTCTGCAGCTAAGGTGATAGCGGAT
GCAAGGAGAGATGGGAAGGTGGTCTATGGTGAACCCATAGCAGCCAGTCTTGGCACAGAT
GGCACTCACTACTGGAATAAAGAATGGCACCATGCAGCCCACCATGTCATGGGTCCACCT
TTGCGACCAGACCCCTCAACACCCGACTTCCTCATGAATCTGTTGGCTAATGATGATCTA
ACCACAACAGGGACTGATAACTGCACTTTCAACACCTGCCAGAAAGCTCTTGGGAAGGAT
GATTTTACCAAGATCCCCAATGGGGTGAATGGTGTTGAAGATCGGATGTCCGTAATATGG
GAAAAAGGCGTGCATAGTGGTAAAATGGATGAAAACAGATTTGTGGCAGTTACCAGCACA
AATGCAGCCAAAATTTTTAATCTCTATCCAAGAAAAGGAAGAATAGCTGTAGGATCAGAT
GCTGACATTGTTATTTGGGACCCAAAAGGCACAAGGACTATCTCAGCAAAAACTCATCAT
CAGGCTGTTAACTTCAACATTTTCGAGGGCATGGTTTGCCACGGGGTGCCCCTTGTGACT
ATTTCAAGAGGCAAAGTGGTATATGAAGCCGGAGTGTTCAGTGTCACGGCAGGAGATGGG
AAGTTTATTCCTCGAAAACCATTTGCTGAATATATTTACAAACGAATAAAGCAGCGAGAC
CGGACTTGCACACCTACCCCTGTGGAGCGTGCACCCTATAAGGGAGAAGTCGCCACACTG
AAATCCAGAGTGACAAAAGAAGATGCCACAGCAGGGACCAGGAAACAGGCCCACCCCTGA


# Metabolic_Enzyme_2_GenBank_ID_Gene:
D78011

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_2_Locus:
8q22

# Metabolic_Enzyme_2_SNPs:
rs7825427; rs2298840; rs35013010; rs2853149; rs2853161; rs2246815; rs2333874; rs2669435; rs2246650; rs2669432; rs870789; rs2853150; rs2853178; rs2853169; rs2853164; rs2669429; rs1317472; rs2669436; rs1317380; rs1319371; rs2333871; rs2251371; rs2853168; rs1325; rs2853158; rs2853155; rs2853160; rs13263121; rs11783979; rs2853151; rs7821992; rs2853181; rs6468929; rs3737535; rs6468928; rs6999483; rs3793358; rs7000266; rs1513025; rs6989588; rs4734106; rs4305867; rs6468924; rs7004911; rs2669438; rs6989484; rs7012764; rs2853170; rs1513026; rs2246827; rs6994920; rs4734793; rs2853154; rs6468927; rs11989338; rs11779762; rs2853167; rs3133279; rs2250601; rs3793354; rs2853157; rs3793356; rs2853176; rs11995044; rs10505058; rs2853180; rs17245950; rs6989353; rs4734794; rs7014456; rs2853159; rs2853174; rs16871364; rs7012566; rs2669434; rs3793355; rs12675680; rs2669425; rs6468926; rs1962267; rs12679642; rs12545205; rs6994791; rs2669431; rs3793352; rs3793357; rs6983974; rs2669421; rs11987822; rs3133278; rs2853175; rs2253336; rs7010772; rs2853173; rs3793351; rs2853172; rs2669420; rs13271902; rs2669427; rs2669426; rs16871363; rs16871365; rs3793361; rs13249169; rs10808391; rs1327; rs4236774; rs2853156; rs2669430; rs2246821; rs16892397; rs13256669; rs1317357; rs13276697; rs2669437; rs6998185; rs13282328; rs10110355; rs2254738; rs13264598; rs2669419; rs16871466; rs3793353; rs4734797; rs7014134; rs10103147; rs2280010; rs7816369; rs17834440; rs6984745; rs2669423; rs13272770; rs3133281; rs2333875; rs12548603; rs3838708; rs2853179; rs4734798; rs17245780; rs2669424; rs2669433; rs7830021; rs4734796; rs2251374; rs1355691; rs16871361; rs16892398; rs6997991; rs2959024; rs2853148; rs2959025; rs36027551; rs34895123; rs35670436; rs35371065; rs2959023; rs6468925; rs6981049; rs11291771; rs34363633; rs36043601; rs35130488; rs35179334; rs5893687; rs34804847; rs34835869; rs34900729; rs3039791; rs3133280; rs34353212; rs1962266; rs34752863; rs35698680; rs13282051; rs17245479; rs34714020; rs34101301; rs34571719; rs33942215; rs35916478; rs34084483; rs35633624; rs7844185; rs35400656; rs11323937; rs35787438; rs2669439; rs2333870; rs28571799; rs35879325; rs35854847; rs10680569; rs28465605; rs4282534; rs35034310; rs35294948; rs35514435; rs10662772; rs5893685; rs11988300; rs1849444; rs35035392; rs35556854; rs34744515; rs2333873; rs36048718; rs2298841; rs35513452; rs35953220; rs2175692; rs35758944; rs13258070; rs10086232; rs5893688; rs7462383; rs13270458; rs34960309; rs34272796; rs34765621; rs11323938; rs2853152; rs35148727; rs35796122; rs35852759; rs35907176; rs1044403; rs35549842; rs2853162; rs34531171; rs2853171; rs7008591; rs34183780; rs2853130; rs34505030; rs13250630; rs35237634; rs3793360; rs6984037; rs11781253; rs7001837; rs28541850; rs11388669; rs35012619; rs34256594; rs4281090; rs35378953; rs3838709; rs28410924; rs35450967; rs7008920; rs34793099; rs1319386; rs2333872; rs2669428; rs2853163; rs13253383; rs34867904; rs11325699; rs35082298; rs5893686; rs35144447; rs34793262; rs3793359; rs36003516; rs36075709; rs3763515; rs34184625; rs28407196; rs34513404; rs10101743; rs1105622; rs11779233; rs11782457; rs11997948; rs12541941; rs12543989; rs1316456; rs1317221; rs1355692; rs2669440; rs2853135; rs2853136; rs2853138; rs2853139; rs2853140; rs2853141; rs2853142; rs2853143; rs2853144; rs2853145; rs2942570; rs2959026; rs2959027; rs35349928; rs3750187; rs4734787; rs4734788; rs4734790; rs6992445

# Metabolic_Enzyme_2_General_References:
8973361; 9718352

# Metabolic_Enzyme_2_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8498

# Macromolecular_Interacting_Partner_1_Name:
Dihydropyrimidinase-related protein 3

# Macromolecular_Interacting_Partner_1_Synonyms:
DRP-3; Unc-33-like phosphoprotein; ULIP protein; Collapsin response mediator protein 4; CRMP-4

# Macromolecular_Interacting_Partner_1_Gene_Name:
DPYSL3

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Dihydropyrimidinaserelated protein 3
MSYQGKKNIPRITSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEA
NGKMVIPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAY
EKWREWADGKSCCDYALHVDITHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTE
LYEIFTCLGELGAIAQVHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAI
TIASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAA
FVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEE
RMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKIV
SAKNHQSAAEYNIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYK
RIKARRKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSARGSPTRPNPPVRNLHQSGFSL
SGTQVDEGVRSASKRIVAPPGGRSNITSLS

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
570

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
61964

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.45

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Nucleotide transport and metabolism

# Macromolecular_Interacting_Partner_1_Specific_Function:
May regulate vesicle function in the growth cone

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01979:Amidohydro_1

# Macromolecular_Interacting_Partner_1_Signals:
Not Available

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
1330242

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
DPYL3_HUMAN (Q14195)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
DPYSL3

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
DPYSL3

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:3015

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cytoplasm. Cell projection; growth cone (By similarity). Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone (By similarity)

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1713 bp
ATGTCCTACCAAGGCAAGAAGAACATCCCGCGGATCACGAGTGACCGTCTCCTTATCAAG
GGAGGCAGAATCGTCAATGATGATCAGTCCTTTTATGCTGATATTTACATGGAAGATGGC
TTAATAAAACAAATTGGAGACAATCTGATTGTTCCTGGAGGAGTGAAGACCATTGAAGCC
AATGGGAAGATGGTGATCCCTGGAGGCATCGATGTCCATACTCACTTCCAGATGCCATAT
AAGGGAATGACCACAGTAGATGACTTCTTCCAAGGGACAAAGGCGGCCTTAGCAGGTGGC
ACCACCATGATCATTGACCATGTGGTGCCTGAGCCTGAGTCCAGCCTGACTGAGGCCTAT
GAGAAATGGAGAGAGTGGGCTGATGGGAAGAGTTGCTGTGACTATGCCCTGCATGTGGAC
ATCACCCACTGGAATGACAGCGTCAAGCAGGAAGTGCAGAACCTCATCAAGGACAAAGGG
GTTAACTCCTTCATGGTTTATATGGCTTATAAGGATTTGTATCAAGTATCTAACACAGAG
CTCTATGAGATCTTCACCTGCCTGGGAGAGCTGGGGGCCATTGCTCAAGTTCATGCTGAG
AATGGGGATATCATTGCCCAGGAGCAAACCCGCATGTTGGAAATGGGGATAACTGGCCCA
GAAGGCCATGTACTGAGCAGGCCAGAAGAGCTGGAAGCTGAGGCTGTGTTCCGTGCCATC
ACCATTGCCAGCCAAACCAATTGCCCTCTCTACGTCACAAAGGTCATGAGCAAGAGTGCA
GCTGACCTCATCTCACAAGCCAGGAAAAAAGGAAATGTAGTCTTTGGTGAGCCCATCACT
GCCAGCCTCGGCATAGATGGAACCCATTATTGGAGCAAGAACTGGGCCAAGGCGGCTGCA
TTTGTGACATCCCCACCCCTGAGCCCTGACCCAACTACTCCGGACTACATCAACTCCTTG
CTGGCCAGCGGGGATCTGCAGCTATCTGGGAGTGCCCACTGCACCTTCAGCACTGCCCAG
AAAGCAATTGGGAAGGACAACTTCACAGCCATTCCTGAGGGCACCAATGGTGTGGAGGAG
CGGATGTCTGTCATCTGGGACAAGGCTGTGGCCACAGGGAAAATGGACGAAAACCAGTTC
GTGGCTGTGACAAGCACAAACGCTGCCAAGATCTTCAACCTGTATCCCCGCAAGGGAAGA
ATATCTGTGGGTTCTGACAGCGACCTCGTCATCTGGGATCCAGATGCTGTGAAGATCGTC
TCTGCCAAGAACCACCAGTCTGCGGCAGAGTACAACATCTTTGAAGGGATGGAGCTGCGC
GGGGCTCCTCTGGTTGTCATCTGCCAGGGCAAGATCATGCTGGAAGATGGCAACCTGCAC
GTGACCCAGGGGGCTGGCCGCTTCATACCCTGCAGCCCGTTCTCCGACTATGTCTACAAG
CGCATTAAAGCACGGAGGAAGATGGCAGACCTGCATGCCGTCCCAAGGGGCATGTACGAT
GGGCCTGTGTTTGACCTGACCACCACCCCCAAAGGTGGCACCCCCGCAGGCTCTGCTCGG
GGCTCTCCTACTCGGCCGAACCCACCTGTGAGGAATCTTCATCAGTCGGGATTTAGCCTG
TCAGGCACCCAAGTGGATGAGGGGGTTCGCTCAGCCAGCAAGCGCATCGTGGCCCCCCCA
GGCGGCCGTTCTAATATCACATCTCTGAGTTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
D78014

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_1_Locus:
5q32

# Macromolecular_Interacting_Partner_1_SNPs:
rs2304044; rs10515587; rs3792837; rs17106709; rs1049171; rs3805533; rs11950394; rs13495; rs3749721; rs10065495; rs2288806; rs2304045; rs1432836; rs1432856; rs2288807; rs2163767; rs1432855; rs6886313; rs6877057; rs3792846; rs6892646; rs3792840; rs7732327; rs3213856; rs4705168; rs10079318; rs1432857; rs3792839; rs2288808; rs12515377; rs3805534; rs2288800; rs12657083; rs4705171; rs1432854; rs995976; rs7716469; rs7700678; rs6891468; rs2241696; rs7720075; rs7737514; rs2278381; rs7730192; rs7725771; rs6897123; rs2288804; rs12657176; rs1864961; rs10056132; rs1432853; rs11955404; rs7737495; rs12514302; rs12653560; rs7725904; rs3816013; rs17484444; rs11960053; rs11952079; rs17096661; rs11167990; rs17550470; rs1864962; rs6580463; rs17106725; rs3213857; rs17106726; rs17106713; rs6887761; rs12657809; rs3805538; rs2288803; rs3805536; rs11953018; rs12655364; rs17106698; rs3816012; rs7713047; rs1432852; rs2288805; rs7737670; rs17106658; rs4705169; rs17550902; rs7720384; rs11738709; rs10052013; rs6866421; rs1030664; rs2288802; rs11952440; rs6861479; rs11950421; rs10059782; rs4705172; rs3805535; rs2304046; rs10045916; rs6873278; rs11738683; rs3805539; rs3213858; rs6867744; rs17106761; rs17106743; rs12655492; rs12515730; rs17106723; rs3805546; rs9885115; rs12518292; rs17106691; rs3805544; rs17106683; rs3792844; rs6877045; rs17106688; rs7710577; rs17106716; rs13168262; rs1121657; rs13340333; rs11958380; rs17106746; rs17106686; rs3805545; rs6899104; rs1549915; rs17106689; rs3792841; rs3805543; rs17106682; rs2078128; rs11948890; rs3792845; rs3805540; rs17106701; rs2304043; rs17106690; rs3792843; rs2288809; rs17106679; rs6879557; rs3805542; rs10043932; rs891947; rs7700723; rs7728665; rs7714137; rs10064194; rs4642416; rs12513884; rs2895681; rs17106620; rs17106765; rs1803521; rs17853869; rs17853868; rs35891125; rs34332356; rs35381274; rs3805532; rs13002; rs35067518; rs1049161; rs6897295; rs1049378; rs1803520; rs34094540; rs13340338; rs7736691; rs36084531; rs10041249; rs3792842; rs36051157; rs34055088; rs28682302; rs35488909; rs10649833; rs13169665; rs4705170; rs10553344; rs2288801; rs41291407; rs35070418; rs34173457; rs11383280; rs34195078; rs41291405; rs35504293; rs11463979; rs35272843; rs34784063; rs6875205; rs1529689; rs34222194; rs10042993; rs3213855; rs10561142; rs34893040; rs2116776; rs9686079; rs35309287; rs34943516; rs35739037; rs5872019; rs2304047; rs13153310; rs41291409; rs35906615; rs35959663; rs10463275; rs35508159; rs34575049; rs3838662; rs11438535; rs4492158; rs13172668; rs3828640; rs10561140; rs34164945; rs13340366; rs3805537; rs3995474; rs35222650; rs10649832; rs11743139; rs28691592; rs34398961; rs36023679; rs35323408; rs6892354; rs9686962; rs36172751; rs13436842; rs35998040; rs35058477; rs10561141; rs34527322; rs35591026; rs34720144; rs10072652; rs10476887; rs10515586; rs11167989; rs1158445; rs11950567; rs12655505; rs1432837; rs1432838; rs17106606; rs17106607; rs17106610; rs1897563; rs729530; rs744585; rs7714240; rs972302

# Macromolecular_Interacting_Partner_1_General_References:
8973361; 9115293

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8721

# Macromolecular_Interacting_Partner_2_Name:
Dihydropyrimidinase-related protein 2

# Macromolecular_Interacting_Partner_2_Synonyms:
DRP-2; Collapsin response mediator protein 2; CRMP-2; N2A3

# Macromolecular_Interacting_Partner_2_Gene_Name:
DPYSL2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Dihydropyrimidinaserelated protein 2
MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEA
HSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAF
DQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQ
IYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAI
TIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAA
FVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEE
RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI
SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYK
RIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFS
LSGAQIDDNIPRRTTQRIVAPPGGRANITSLG

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
572

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
62294

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.33

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Nucleotide transport and metabolism

# Macromolecular_Interacting_Partner_2_Specific_Function:
Involved in neuronal growth cone collapse. Induces axon formation

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF01979:Amidohydro_1

# Macromolecular_Interacting_Partner_2_Signals:
Not Available

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
1244400

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
DPYL2_HUMAN (Q16555)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
DPYSL2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
DPYSL2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:3014

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cytoplasm (Potential)

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1719 bp
ATGTCTTATCAGGGGAAGAAAAATATTCCACGCATCACGAGCGATCGTCTTCTGATCAAA
GGAGGTAAAATTGTTAATGATGACCAGTCGTTCTATGCAGACATATACATGGAAGATGGG
TTGATCAAGCAAATAGGAGAAAATCTGATTGTGCCAGGAGGAGTGAAGACCATCGAGGCC
CACTCCCGGATGGTGATCCCCGGAGGAATTGACGTCCACACTCGTTTCCAGATGCCTGAT
CAGGGAATGACGTCTGCTGATGATTTCTTCCAAGGAACCAAGGCGGCCCTGGCTGGGGGA
ACCACTATGATCATTGACCACGTTGTTCCTGAGCCTGGGACAAGCCTGCTCGCTGCCTTT
GACCAGTGGAGGGAATGGGCCGACAGCAAGTCCTGCTGTGACTACTCTCTGCATGTGGAC
ATCAGCGAGTGGCATAAGGGCATCCAGGAGGAGATGGAAGCGCTTGTGAAGGATCACGGG
GTAAATTCCTTCCTCGTGTACATGGCTTTCAAAGATCGCTTCCAGCTAACGGATTGCCAG
ATTTATGAAGTACTGAGTGTGATCCGGGATATTGGCGCCATAGCCCAAGTCCACGCAGAA
AATGGCGACATCATTGCAGAGGAGCAGCAGAGGATCCTGGATCTGGGCATCACGGGCCCC
GAGGGACATGTGCTGAGCCGACCTGAGGAGGTCGAGGCCGAAGCCGTGAATCGTGCCATC
ACCATCGCCAACCAGACCAACTGCCCGCTGTATATCACCAAGGTGATGAGCAAAAGCTCT
GCTGAGGTCATCGCCCAGGCACGGAAGAAGGGAACTGTGGTGTATGGCGAGCCCATCACT
GCCAGCTTGGGAACGGACGGCTCCCATTACTGGAGCAAGAACTGGGCCAAGGCTGCTGCC
TTTGTCACCTCCCCACCCTTGAGCCCTGATCCAACCACTCCAGACTTTCTCAACTCCTTG
CTGTCCTGTGGAGACCTCCAGGTCACGGGCAGTGCCCATTGCACGTTTAACACTGCCCAG
AAGGCTGTAGGAAAGGACAACTTCACCCTGATTCCGGAGGGCACCAATGGCACTGAGGAG
CGGATGTCCGTCATCTGGGACAAGGCTGTGGTCACTGGGAAGATGGATGAGAACCAGTTT
GTGGCTGTGACCAGCACCAATGCAGCCAAAGTCTTCAACCTTTACCCCCGGAAAGGCCGC
ATTGCTGTGGGATCCGATGCCGACCTGGTCATCTGGGACCCCGACAGCGTTAAAACCATC
TCTGCCAAGACACACAACAGCTCTCTCGAGTACAACATCTTTGAAGGCATGGAGTGCCGC
GGCTCCCCACTGGTGGTCATCAGCCAGGGGAAGATTGTCCTGGAGGACGGCACCCTGCAT
GTCACCGAAGGCTCTGGACGCTACATTCCCCGGAAGCCCTTCCCTGATTTTGTTTACAAG
CGTATCAAGGCAAGGAGCAGGCTGGCTGAGCTGAGAGGGGTTCCTCGTGGCCTGTATGAC
GGACCCGTGTGTGAAGTGTCTGTGACGCCCAAGACAGTCACTCCAGCCTCCTCGGCCAAG
ACGTCTCCTGCCAAGCAGCAGGCCCCACCTGTCCGGAACCTGCACCAGTCTGGATTCAGT
TTGTCTGGTGCTCAGATTGATGACAACATTCCCCGCCGCACCACCCAGCGTATCGTGGCG
CCCCCCGGTGGCCGTGCCAACATCACCAGCCTGGGCTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
U17279

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:8

# Macromolecular_Interacting_Partner_2_Locus:
8p22-p21

# Macromolecular_Interacting_Partner_2_SNPs:
rs2289593; rs327222; rs11786691; rs708621; rs920633; rs11863; rs17666; rs1058332; rs10495; rs17055646; rs3739219; rs17055641; rs10042; rs327215; rs2585459; rs1992472; rs1972921; rs327225; rs894509; rs327224; rs749936; rs448872; rs930470; rs385351; rs920697; rs1867042; rs327218; rs388047; rs327234; rs1561818; rs6992095; rs452787; rs1662248; rs451164; rs327226; rs11135950; rs6557933; rs327233; rs7825468; rs327221; rs6557930; rs11135951; rs4872457; rs13271910; rs398008; rs7004868; rs2034040; rs7829347; rs7841384; rs2289592; rs10088957; rs376954; rs6557931; rs7834325; rs384908; rs7835006; rs6557929; rs7832234; rs182748; rs6988996; rs920632; rs2584187; rs408753; rs7011131; rs6990931; rs12234932; rs4733048; rs749937; rs327223; rs920631; rs327230; rs7820433; rs327232; rs7840494; rs4733044; rs5022821; rs9644116; rs11995227; rs17322303; rs7812694; rs753508; rs327229; rs17322324; rs6557927; rs12678418; rs429591; rs17055516; rs17055593; rs11775462; rs17322275; rs17321828; rs12541748; rs4733033; rs11782869; rs11775497; rs17055515; rs999772; rs13277175; rs17322640; rs6557928; rs12677999; rs749935; rs9644117; rs4478581; rs17322528; rs4733013; rs327237; rs17322366; rs11776975; rs11775862; rs17055486; rs11774146; rs17405591; rs10093591; rs11776801; rs5029306; rs327227; rs7001738; rs1442336; rs327217; rs11780026; rs9644118; rs17406372; rs17055585; rs17405668; rs12550663; rs2585457; rs7832576; rs12677981; rs13250931; rs4076071; rs5022822; rs13249892; rs753509; rs429787; rs7818193; rs11778165; rs2083739; rs4732714; rs415524; rs17055546; rs11783896; rs12541952; rs17055500; rs12549410; rs403185; rs11775967; rs17055504; rs2120049; rs17055487; rs11775859; rs12546827; rs12546828; rs1808892; rs17322408; rs17321041; rs17055489; rs327228; rs11781865; rs12545134; rs327216; rs17322051; rs11780034; rs17088245; rs17419937; rs11990271; rs379266; rs17055482; rs17055494; rs7845756; rs7816762; rs17055502; rs17055605; rs2585458; rs10441614; rs7015088; rs17055514; rs7460917; rs327236; rs7008546; rs17055492; rs11780147; rs2322130; rs11784967; rs11781198; rs7009085; rs17055537; rs17055582; rs17055480; rs327214; rs327235; rs17055521; rs13249543; rs6557932; rs17055536; rs13260473; rs371255; rs3808564; rs6988457; rs6557926; rs17055491; rs11995685; rs6998628; rs6983262; rs7827731; rs7828056; rs2585456; rs445678; rs400181; rs367948; rs35621323; rs4733059; rs34588307; rs1803519; rs35258691; rs11527; rs34335048; rs17055639; rs3837184; rs1058457; rs41276289; rs34673092; rs35314544; rs1058333; rs1058313; rs11399423; rs35690946; rs28470992; rs34792838; rs34382438; rs6982026; rs390323; rs41276287; rs41276285; rs399788; rs34226529; rs34238466; rs920630; rs167855; rs34978863; rs28649929; rs34204302; rs2584183; rs35446474; rs3074034; rs34051886; rs35134585; rs34375962; rs10691983; rs35587383; rs2584182; rs35321818; rs11427313; rs35493897; rs920695; rs11400209; rs10584379; rs35273847; rs34633365; rs13262574; rs11998448; rs35225449; rs35476823; rs35253282; rs7010042; rs13248890; rs2584184; rs2120048; rs10556349; rs28889579; rs35219984; rs7015859; rs28750171; rs13276391; rs3074029; rs35474814; rs35226523; rs327213; rs34151191; rs7828110; rs33993906; rs11399087; rs11786298; rs11384905; rs3926189; rs12542360; rs36063450; rs7002026; rs17055594; rs327220; rs34880068; rs36110958; rs3779913; rs34241661; rs35006006; rs35117658; rs327231; rs10690987; rs35491396; rs33963820; rs36177037; rs4055147; rs11383598; rs35692875; rs28498128; rs11287159; rs1442337; rs34321710; rs7017875; rs35004176; rs35696405; rs4733051; rs7014178; rs2584185; rs35346128; rs35539107; rs34007808; rs7820494; rs35258351; rs35498265; rs11427312; rs35717375; rs10690986; rs11357827; rs35866474; rs35153261; rs41432246; rs7821827; rs378278; rs11285674; rs35363743; rs1966766; rs11355802; rs10606826; rs431246; rs3840708; rs17088240; rs11774816; rs11778187; rs11784283; rs11786284; rs11993953; rs12155555; rs13249662; rs13258612; rs13259621; rs13275466; rs17055673; rs17088247; rs17088251; rs17320101; rs17320156; rs17330335; rs2584188; rs2585455; rs364508; rs380423; rs401004; rs408157; rs418624; rs424422; rs429020; rs431217; rs442103; rs6557935; rs6987195; rs6987220; rs7827953; rs7831883; rs7842128; rs7845740; rs894330; rs920696; rs9644119

# Macromolecular_Interacting_Partner_2_General_References:
7637782; 8973361; 10574455; 10757975

# Macromolecular_Interacting_Partner_2_References:
Not Available

End of HMDB00076

Beginning of HMDB00077
# Accession_No:
HMDB00077

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-10 12:30:32

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Dehydroepiandrosterone

# Description:
Dehydroepiandrosterone (DHEA) is a natural steroid hormone produced from cholesterol by the adrenal glands. DHEA is also produced in the gonads, adipose tissue and the brain. DHEA is structurally similar to, and is a precursor of, androstenedione, testosterone, estradiol, estrone and estrogen. It is the most abundant hormone in the human body. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE- DEHAS) before secretion. DHEAS is the sulfated version of DHEA; - this conversion is reversibly catalyzed by sulfotransferase (SULT2A1) primarily in the adrenals, the liver, and small intestines. In blood, most DHEA is found as DHEAS with levels that are about 300 times higher than free DHEA. Blood measurements of DHEAS/DHEA are useful to detect excess adrenal activity as seen in adrenal cancer or hyperplasia, including certain forms of congenital adrenal hyperplasia. Women with polycystic ovary syndrome tend to have normal or mildly elevated levels of DHEAS.

# Synonyms:
(+)-Dehydroisoandrosterone; (3-beta)-3-Hydroxyandrost-5-en-17-one; (3beta)-3-hydroxy-Androst-5-en-17-one; (3beta,16alpha)-3,16-dihydroxy-androst-5-en-17-one; 17-Chetovis; 17-Hormoforin; 3-Hydroxyandrost-5-en-17-one; 3-beta-Hydroxy-5-androsten-17-one; 3-beta-Hydroxyandrost-5-en-17-one; 3b-Hydroxy-D5-androsten-17-one; 3b-Hydroxyandrost-5-en-17-one; 3b-Hydroxyandrost-5-ene-17-one; 3b-hydroxy-Androst-5-en-17-one; 3beta-Hydroxy-D5-androsten-17-one; 3beta-Hydroxyandrost-5-en-17-one; 3beta-Hydroxyandrost-5-ene-17-one; 3beta-hydroxy-5-androsten-17-one; 3beta-hydroxy-Androst-5-en-17-one; 5,6-Dehydroisoandrosterone; 5,6-Didehydroisoandrosterone; 5-Androsten-3-beta-ol-17-one; 5-Androsten-3B-ol-17-one; 5-Androsten-3beta-ol-17-one; 5-Dehydroepiandrosterone; 5-dehydro-Epiandrosterone; AND; Andrestenol; Androst-5-ene-3b-ol-17-one; Androst-5-ene-3beta-ol-17-one; Androsten-3beta-ol-17-one; Androstenolone; Astenile; D5-Androsten-3b-ol-17-one; D5-Androsten-3beta-ol-17-one; DHA; DHEA; Deandros; Dehydro-epi-androsterone; Dehydroepiandrosterone; Dehydroisoandrosterone; Delta5-androsten-3-beta-ol-17-one; Diandron; Diandrone; Hydroxyandrostenone; Prasterona; Prasterone; Prasteronum; Prestara; Psicosterone; Siscelar plus; dehydroepiandrosterone for biochemistry; hydroxy-androst-5-en-17-one; trans-Dehydroandrosterone; trans-de-hydroandrosterone

# Chemical_IUPAC_Name:
3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one

# Chemical_Formula:
C19H28O2

# Chemical_Structure:
tbl_chemical:::HMDB00077_ZOOM.png:::119283176887169847

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00077_THUMB.png:::119283176682895210

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Steroids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
ketone; secondary alcohol; alkene

# Taxonomy_Biofunction:
Component of Androgen and estrogen metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
288.20895

# Molecular_Weight_Avg:
288.42444

# Smiles_String_isomeric:
C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@]34C)[C@@H]1CCC2=O

# Smiles_String_canonical:
CC12CCC3C(CC=C4CC(O)CCC34C)C1CCC2=O

# KEGG_Compound_ID:
C01227

# BioCyc_ID:
DEHYDRO-EPIANDROSTERONE-SULFATE

# PubChem_CID:
5881

# PubChem_SID:
8153636; 4449; 841442; 148684; 596018; 75250; 12014907; 11446567; 8145544; 7851871; 798262; 837865; 12060384; 7885884; 835985; 3135651

# OMIM_ID:
Not Available

# Metagene_ID:
3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY: 95; 21-HYDROXYLASE DEFICIENCY (CYP21): 235

# BiGG_ID:
37131

# Wikipedia_ID:
Dehydroepiandrosterone

# METLIN_ID:
5133

# Ref_ID:
12667489; 1316232; 12828082; 14989701; 2141293; 1620285; 12676372; 6210977; 16521435; 3160310; 11281367; 16095120; 14625002; 14602750; 15650074; 14977864; 16487434

# ChEBI_ID:
28689

# CAS_Registry_Number:
53-43-0

# InChI:
InChI=1/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1

# Synthesis_Reference:
Journal of the Chemical Society  (1953),     361-84.

# Melting_Point:
140-141 oC

# Melting_Point_predicted:
124.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.0635 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
0.0438 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
3.23 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
3.53 [Predicted by ALOGPS]; 3 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Dehydroepiandrosterone.pdf:::1132562197625577486

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Dehydroepiandrosterone.mol:::113336905370082490

# SDF_File_[Text]:
tbl_chemical:::HMDB00077.sdf:::119283176089152943

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00077.pdb:::119283176530293820

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::00077_Dehydropiandrostreone.zip:::118253390969689237

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050105_P00_06_IS_assigned.png:::118253390976342767

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050105_P00_06_IS_2DHSQC_74.png:::114828723847627765

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050105_P00_06_IS_2DHSQC_74.zip:::114828723854368651

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050105_P00_06_IS_2DHSQC_74_Assigned.png:::116242641674494654

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Dehydroepiandrosterone.gif:::1132732106031823063

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00077_peaks.txt:::1156309530717788991

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Dehydroepiandrosterone_C.gif:::1132737676845665557

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00077_peaks.txt:::1156310721076596534

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00077L.png:::117555262296482112; Medium Energy:tbl_ms:::HMDB00077M.png:::117555267615239663; High Energy:tbl_ms:::HMDB00077H.png:::117555271245436613

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane (Predicted from LogP); Cytoplasm; endoplasmic reticulum

# Tissue_Location:
Adipose Tissue; Adrenal Cortex; Adrenal Gland; Adrenal Glands; Brain; Epidermis; Fibroblasts; Gonads; Kidneys; Liver; Muscle; Neurons; Placenta; Platelet; Prostate; Testes; Testis

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Blood	0.00034-0.0017	uM	Children:1-13_yrs_old	Female	Normal	14625002
Blood	0.0087 (0.0035-0.013)	uM	Adult:>18_yrs_old	Female	Normal	14625002
Blood	0.023 (0.0045-0.042)	umol/L	Adult:>18_yrs_old	Both	Normal	Merck Manual
Cerebrospinal_Fluid(CSF)	0.00101 (0.00002-0.002)	umol/L	Adult:>18_yrs_old	N/A	Normal	1620285
Saliva	0.0033 (0.0024-0.0090)	umol/L	Adult:>18_yrs_old	Both	Normal	6210977


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
21-hydroxylase Deficiency; Adrenal Cancer; Benign gynecological diseases; Cardiovascular Disease; Congenital Adrenal Hyperplasia; Polycystic Ovary Syndrome (PCOS)

# Pathway_Names:
Androgen and estrogen metabolism;C21-Steroid hormone metabolism

# Pathway_Images:
;

# KEGG_Images:
map00150;map00140

# Pathway_Graphs:
;

# Pathway_SBMLs:
;

# Metabolic_Enzyme_1_ID:
5740

# Metabolic_Enzyme_1_Name:
Steryl-sulfatase precursor

# Metabolic_Enzyme_1_Synonyms:
Steroid sulfatase; Steryl- sulfate sulfohydrolase; Arylsulfatase C; ASC

# Metabolic_Enzyme_1_Gene_Name:
STS

# Metabolic_Enzyme_1_Protein_Sequence:
>Sterylsulfatase precursor
MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLAS
GGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAK
LLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTT
GFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPL
NCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFA
GKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGS
NGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRI
IDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNG
CFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQT
LPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR

# Metabolic_Enzyme_1_Number_of_Residues:
583

# Metabolic_Enzyme_1_Molecular_Weight:
65493

# Metabolic_Enzyme_1_Theoretical_pI:
7.71

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  sulfuric ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Conversion of sulfated steroid precursors to estrogens during pregnancy

# Metabolic_Enzyme_1_Pathway:
map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_1_Reaction:
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00884:Sulfatase

# Metabolic_Enzyme_1_Signals:
1-21

# Metabolic_Enzyme_1_Transmembrane_Regions:
185-208
213-234

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.1.6.2

# Metabolic_Enzyme_1_GenBank_ID_Protein:
338565

# Metabolic_Enzyme_1_SwissProt_ID:
STS_HUMAN (P08842)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
STS

# Metabolic_Enzyme_1_Geneatlas_id:
STS

# Metabolic_Enzyme_1_hgnc_id:
HGNC:11425

# Metabolic_Enzyme_1_PDB_ID:
1P49

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein

# Metabolic_Enzyme_1_Gene_Sequence:
>1752 bp
ATGCCTTTAAGGAAGATGAAGATCCCTTTCCTCCTACTGTTCTTTCTGTGGGAAGCCGAG
AGCCACGCAGCATCAAGGCCGAACATCATCCTGGTGATGGCTGACGACCTCGGCATTGGA
GATCCTGGGTGCTATGGGAACAAAACTATCAGGACTCCCAATATCGACCGGTTGGCCAGT
GGGGGAGTGAAACTCACTCAGCACCTGGCAGCATCACCGCTGTGCACACCAAGCAGGGCA
GCCTTCATGACTGGCCGGTACCCTGTCCGATCAGGAATGGCATCTTGGTCCCGCACTGGA
GTTTTCCTCTTCACAGCCTCTTCGGGAGGACTTCCCACCGATGAGATTACCTTTGCTAAG
CTTCTGAAGGATCAAGGTTATTCAACAGCACTGATAGGGAAATGGCACCTTGGGATGAGC
TGTCACAGCAAGACTGACTTCTGTCACCACCCTTTACATCACGGCTTCAATTATTTCTAT
GGGATCTCTTTGACCAATCTGAGAGACTGCAAGCCCGGAGAGGGCAGTGTCTTCACCACG
GGCTTCAAGAGGCTGGTCTTCCTCCCCCTGCAGATCGTCGGGGTCACCCTCCTTACCCTT
GCTGCACTCAATTGTCTGGGGCTACTCCACGTGCCTCTAGGCGTTTTTTTCAGCCTTCTC
TTCCTAGCAGCCCTAATCCTGACCCTTTTCTTGGGCTTCCTTCATTACTTCCGGCCCCTG
AACTGCTTCATGATGAGGAACTACGAGATCATTCAGCAGCCCATGTCCTATGACAATCTC
ACCCAGAGGCTAACGGTGGAGGCGGCCCAGTTCATACAGCGGAACACTGAGACTCCGTTC
CTGCTTGTCTTGTCCTACCTCCACGTGCACACAGCCCTGTTCTCCAGCAAAGACTTTGCT
GGCAAAAGTCAACACGGAGTCTACGGGGATGCTGTTGAGGAAATGGACTGGAGTGTGGGG
CAGATCTTGAACCTTCTGGATGAGCTGAGATTGGCTAATGATACCCTCATCTACTTCACA
TCGGACCAGGGAGCACATGTAGAGGAGGTGTCTTCCAAAGGAGAAATTCATGGCGGAAGT
AATGGGATCTATAAAGGAGGAAAAGCAAACAACTGGGAAGGAGGTATCCGGGTTCCAGGC
ATCCTTCGTTGGCCCAGGGTGATACAGGCTGGCCAGAAGATTGATGAGCCCACTAGCAAC
ATGGACATATTTCCTACAGTAGCCAAGCTGGCTGGAGCTCCCTTGCCTGAGGACAGGATC
ATTGATGGACGTGATCTGATGCCCCTGCTTGAAGGAAAAAGCCAACGCTCCGATCATGAG
TTTCTCTTCCATTACTGCAACGCCTACTTAAATGCTGTGCGCTGGCACCCTCAGAACAGC
ACATCCATCTGGAAGGCCTTTTTCTTCACCCCCAACTTCAACCCCGTGGGTTCCAACGGA
TGCTTTGCCACACACGTGTGCTTCTGTTTCGGGAGTTATGTCACCCATCACGACCCACCT
TTACTCTTTGATATTTCCAAAGATCCCAGAGAGAGAAACCCACTAACTCCAGCATCCGAG
CCCCGGTTTTATGAAATCCTCAAAGTCATGCAGGAAGCTGCGGACAGACACACCCAGACC
CTGCCAGAGGTGCCCGATCAGTTTTCATGGAACAACTTTCTTTGGAAGCCCTGGCTTCAG
CTGTGCTGTCCTTCCACCGGCCTGTCTTGCCAGTGTGATAGAGAAAAACAGGATAAGAGA
CTGAGCCGCTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
J04964

# Metabolic_Enzyme_1_Chromosome_Location:
Not Available

# Metabolic_Enzyme_1_Locus:
Not Available

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
2668275; 3032454; 3203382; 2765556; 12657638; 1539590; 9252398; 10679952; 10844566

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5737

# Metabolic_Enzyme_2_Name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II

# Metabolic_Enzyme_2_Synonyms:
3- beta-HSD II[Includes: 3-beta-hydroxy-Delta(5-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta-isomerase; Delta- 5-3-ketosteroid isomerase]

# Metabolic_Enzyme_2_Gene_Name:
HSD3B2

# Metabolic_Enzyme_2_Protein_Sequence:
>3 betahydroxysteroid dehydrogenase/Delta 5>4isomerase type II
MGWSCLVTGAGGLLGQRIVRLLVEEKELKEIRALDKAFRPELREEFSKLQNRTKLTVLEG
DILDEPFLKR
ACQDVSVVIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVF
IYTSSIEVAGPNSYKEIIQNG
HEEEPLENTWPTPYPYSKKLAEKAVLAANGWNLKNGDT
LYTCALRPTYIYGEGGPFLSASINEALNNNGI
LSSVGKFSTVNPVYVGNVAWAHILALR
ALRDPKKAPSVRGQFYYISDDTPHQSYDNLNYILSKEFGLRLD
SRWSLPLTLMYWIGFL
LEVVSFLLSPIYSYQPPFNRHTVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQ
KTVEW
VGSLVDRHKETLKSKTQ

# Metabolic_Enzyme_2_Number_of_Residues:
372

# Metabolic_Enzyme_2_Molecular_Weight:
42053

# Metabolic_Enzyme_2_Theoretical_pI:
8.17

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, transposing C=C bonds
Function:  steroid delta-isomerase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  3-beta-hydroxy-delta5-steroid dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_2_Specific_Function:
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids

# Metabolic_Enzyme_2_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_2_Reaction:
A 3-oxo-delta5-steroid = a 3-oxo-delta4-steroid

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01073:3Beta_HSD

# Metabolic_Enzyme_2_Signals:
1-15

# Metabolic_Enzyme_2_Transmembrane_Regions:
287-307

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.1.145;EC 5.3.3.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
184401

# Metabolic_Enzyme_2_SwissProt_ID:
3BHS2_HUMAN (P26439)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
HSD3B2

# Metabolic_Enzyme_2_Geneatlas_id:
HSD3B2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:5218

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein. Mitochondrion; mitochondrial membrane; single-pass membrane protein

# Metabolic_Enzyme_2_Gene_Sequence:
>1119 bp

ATGGGCTGGAGCTGCCTTGTGACAGGAGCAGGAGGGCTTCTGGGTCAGAGGATCGTCCG
CCTGTTGGTGG
AAGAGAAGGAACTGAAGGAGATCAGGGCCTTGGACAAGGCCTTCAGAC
CAGAATTGAGAGAGGAATTTTC
TAAGCTCCAGAACAGGACCAAGCTGACTGTACTTGAA
GGAGACATTCTGGATGAGCCATTCCTGAAAAGA
GCCTGCCAGGACGTCTCGGTCGTCAT
CCACACCGCCTGTATCATTGATGTCTTTGGTGTCACTCACAGAG
AGTCCATCATGAATG
TCAATGTGAAAGGTACCCAGCTACTGTTGGAGGCCTGTGTCCAAGCCAGTGTGCC
AGTC
TTCATCTACACCAGTAGCATAGAGGTAGCCGGGCCCAACTCCTACAAGGAAATCATCCAG
AACGGC
CACGAAGAAGAGCCTCTGGAAAACACATGGCCCACTCCATACCCGTACAGCAA
AAAGCTTGCTGAGAAGG
CTGTGCTGGCGGCTAATGGGTGGAATCTAAAAAATGGTGATA
CCTTGTACACTTGTGCGTTAAGACCCAC
ATATATCTATGGGGAAGGAGGCCCATTCCTT
TCTGCCAGTATAAATGAGGCCCTGAACAACAATGGGATC
CTGTCAAGTGTTGGAAAGTT
CTCTACAGTCAACCCAGTCTATGTTGGCAACGTGGCCTGGGCCCACATTC
TGGCCTTGA
GGGCTCTGCGGGACCCCAAGAAGGCCCCAAGTGTCCGAGGTCAATTCTATTACATCTCAG
A
TGACACGCCTCACCAAAGCTATGATAACCTTAATTACATCCTGAGCAAAGAGTTTGGC
CTCCGCCTTGAT
TCCAGATGGAGCCTTCCTTTAACCCTGATGTACTGGATTGGCTTCCT
GCTGGAAGTAGTGAGCTTCCTAC
TCAGCCCAATTTACTCCTATCAACCCCCCTTCAACC
GCCACACAGTCACATTATCAAATAGTGTGTTCAC
CTTCTCTTACAAGAAGGCTCAGCGA
GATCTGGCGTATAAGCCACTCTACAGCTGGGAGGAAGCCAAGCAG
AAAACCGTGGAGTG
GGTTGGTTCCCTTGTGGACCGGCACAAGGAGACCCTGAAGTCCAAGACTCAGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M67466

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_2_Locus:
1p13.1

# Metabolic_Enzyme_2_SNPs:
rs4986954; rs6211; rs35887327; rs6207; rs33926546; rs34412477; rs33932258; rs1819698; rs1361530; rs9282704; rs6208; rs6210; rs9282703; rs3753258; rs12411115; rs2854961; rs33920337; rs17023577; rs12044792; rs2854964; rs10923817; rs3765948; rs12411080; rs2854963; rs2793133; rs7411891; rs2854962; rs2793132; rs6676988; rs4659174; rs12062744; rs33952871; rs33963971; rs4659175; rs35983269; rs34492690; rs34177617; rs35954381; rs35344469; rs35569514; rs9282705; rs28943871; rs35613222; rs28934880; rs35486059; rs34562248; rs714748; rs10591825; rs10616581; rs34234813; rs12741109; rs3057393; rs35081017; rs3820030; rs6692175; rs10616582; rs12742063; rs12404035; rs12741125; rs36021225; rs36022499; rs5777392; rs12723698; rs35507723; rs35448442; rs35847875; rs34282330; rs10754396; rs10923815; rs10923819; rs10923820; rs11579951; rs12022215; rs12403392; rs12404131; rs12405488; rs1341018; rs17023564; rs2185556; rs2185557; rs6661603; rs947129

# Metabolic_Enzyme_2_General_References:
1944309; 1741954; 8316254; 7833923; 8126127; 7962268; 8185809; 8060486; 7893703; 7633426; 7633460; 7608265; 9719627; 10599696; 10651755; 10843183; 12050213

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5583

# Metabolic_Enzyme_3_Name:
Bile salt sulfotransferase

# Metabolic_Enzyme_3_Synonyms:
Hydroxysteroid Sulfotransferase; HST; Dehydroepiandrosterone sulfotransferase; DHEA-ST; ST2; ST2A3

# Metabolic_Enzyme_3_Gene_Name:
SULT2A1

# Metabolic_Enzyme_3_Protein_Sequence:
>Bile salt sulfotransferase
MSDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSK
GDAKWIQSVP
IWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYL
MRNPRDVLVSGYFFWKNMKFI
KKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKN
FLLLSYEELKQDTGRTIEKICQFLGKTLEPEE
LNLILKNSSFQSMKENKMSNYSLLSVD
YVVDKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRE
LFPWE

# Metabolic_Enzyme_3_Number_of_Residues:
285

# Metabolic_Enzyme_3_Molecular_Weight:
33780

# Metabolic_Enzyme_3_Theoretical_pI:
5.76

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands

# Metabolic_Enzyme_3_Pathway:
Not Available

# Metabolic_Enzyme_3_Reaction:
3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.8.2.14

# Metabolic_Enzyme_3_GenBank_ID_Protein:
306702

# Metabolic_Enzyme_3_SwissProt_ID:
ST2A1_HUMAN (Q06520)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
SULT2A1

# Metabolic_Enzyme_3_Geneatlas_id:
SULT2A1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:11458

# Metabolic_Enzyme_3_PDB_ID:
1OV4

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>858 bp

ATGTCGGACGATTTCTTATGGTTTGAAGGCATAGCTTTCCCTACTATGGGTTTCAGATC
CGAAACCTTAA
GAAAAGTACGTGATGAGTTCGTGATAAGGGATGAAGATGTAATAATAT
TGACTTACCCCAAATCAGGAAC
AAACTGGTTGGCTGAGATTCTCTGCCTGATGCACTCC
AAGGGGGATGCCAAGTGGATCCAATCTGTGCCC
ATCTGGGAGCGATCACCCTGGGTAGA
GAGTGAGATTGGGTATACAGCACTCAGTGAAAGCGAGAGTCCAC
GTTTATTCTCCTCCC
ACCTCCCCATCCAGTTATTCCCCAAGTCTTTCTTCAGTTCCAAGGCCAAGGTGAT
TTAT
CTCATGAGAAATCCCAGAGATGTTTTGGTGTCTGGTTATTTTTTCTGGAAAAACATGAAG
TTTATT
AAGAAACCAAAGTCATGGGAAGAATATTTTGAATGGTTTTGTCAAGGAACTGT
GCTATATGGGTCATGGT
TTGACCACATTCATGGCTGGATGCCCATGAGAGAGGAGAAAA
ACTTCCTGTTACTGAGTTATGAGGAGCT
GAAACAGGACACAGGAAGAACCATAGAGAAG
ATCTGTCAATTCCTGGGAAAGACGTTAGAACCCGAAGAA
CTGAACTTAATTCTCAAGAA
CAGCTCCTTTCAGAGCATGAAAGAAAACAAGATGTCCAATTATTCCCTCC
TGAGTGTTG
ATTATGTAGTGGACAAAGCACAACTTCTGAGAAAAGGTGTATCTGGGGACTGGAAAAATC
A
CTTCACAGTGGCCCAAGCTGAAGACTTTGATAAATTGTTCCAAGAGAAGATGGCAGAT
CTTCCTCGAGAG
CTGTTCCCATGGGAATAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
L20000

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_3_Locus:
19q13.3

# Metabolic_Enzyme_3_SNPs:
rs11569681; rs11569679; rs11569685; rs11083907; rs296365; rs11083903; rs296366; rs296367; rs2547238; rs2547241; rs212099; rs4149448; rs2910394; rs2547236; rs11083905; rs11671690; rs2547240; rs11083904; rs2637116; rs296364; rs2431829; rs296361; rs2431828; rs2431830; rs2547237; rs2910393; rs11083906; rs4149452; rs10425629; rs10426201; rs296362; rs10401763; rs296359; rs296363; rs2547235; rs7247968; rs9676884; rs212100; rs8113396; rs2547242; rs2451834; rs2547231; rs12461808; rs10425975; rs2547239; rs8108674; rs16972519; rs10420308; rs4149449; rs10425154; rs7256697; rs182420; rs296368; rs188440; rs2932766; rs10401229; rs7508610; rs10402030; rs17464626; rs177037; rs17851828; rs1131405; rs1131404; rs4149454; rs10416994; rs36012387; rs10676904; rs10048437; rs34884527; rs10697302; rs35135607; rs11668504; rs10425963; rs35486252; rs36196588; rs35795715; rs12461162; rs7251378; rs12985420; rs35150217; rs4149451; rs34559609; rs34468125; rs34642376; rs34027366; rs34692560; rs9304669; rs4149450; rs2637115; rs2547234; rs11352410; rs34339793; rs12151061; rs12975483; rs3936308; rs35243293; rs296360; rs2547233; rs2972624; rs35067360; rs28830294; rs2972622; rs35543847; rs35489406; rs4002939; rs35975330; rs177036; rs2910392; rs2972623; rs28505302; rs28762460; rs8104798; rs11569677; rs11569678; rs11569680; rs11569683; rs11569684; rs12461421; rs2547229; rs2910397; rs2910400; rs296381; rs296390; rs296391; rs296394; rs2972612; rs6509347; rs6509348; rs8105359

# Metabolic_Enzyme_3_General_References:
7678732; 1588921; 7589785; 7598806; 7710689; 1520333

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5738

# Metabolic_Enzyme_4_Name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I

# Metabolic_Enzyme_4_Synonyms:
3- beta-HSD I; Trophoblast antigen FDO161G[Includes: 3-beta-hydroxy- Delta(5-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta- isomerase; Delta-5-3-ketosteroid isomerase]

# Metabolic_Enzyme_4_Gene_Name:
HSD3B1

# Metabolic_Enzyme_4_Protein_Sequence:
>3 betahydroxysteroid dehydrogenase/Delta 5>4isomerase type I
MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELREEFSKLQNKTKLTVLE
GDILDEPFLK
RACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPV
FIYTSSIEVAGPNSYKEIIQN
GHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGG
TLYTCALRPMYIYGEGSRFLSASINEALNNNG
ILSSVGKFSTVNPVYVGNVAWAHILAL
RALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRL
DSRWSFPLSLMYWIGF
LLEIVSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAK
QKTVE
WVGSLVDRHKETLKSKTQ

# Metabolic_Enzyme_4_Number_of_Residues:
373

# Metabolic_Enzyme_4_Molecular_Weight:
42252

# Metabolic_Enzyme_4_Theoretical_pI:
8.98

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, transposing C=C bonds
Function:  steroid delta-isomerase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  3-beta-hydroxy-delta5-steroid dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_4_Specific_Function:
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids

# Metabolic_Enzyme_4_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_4_Reaction:
A 3-oxo-delta5-steroid = a 3-oxo-delta4-steroid

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01073:3Beta_HSD

# Metabolic_Enzyme_4_Signals:
1-13

# Metabolic_Enzyme_4_Transmembrane_Regions:
288-308

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.1.1.145;EC 5.3.3.1

# Metabolic_Enzyme_4_GenBank_ID_Protein:
306889

# Metabolic_Enzyme_4_SwissProt_ID:
3BHS1_HUMAN (P14060)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
HSD3B1

# Metabolic_Enzyme_4_Geneatlas_id:
HSD3B1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:5217

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein. Mitochondrion; mitochondrial membrane; single-pass membrane protein

# Metabolic_Enzyme_4_Gene_Sequence:
>1122 bp

ATGACGGGCTGGAGCTGCCTTGTGACAGGAGCAGGAGGGTTTCTGGGACAGAGGATCAT
CCGCCTCTTGG
TGAAGGAGAAGGAGCTGAAGGAGATCAGGGTCTTGGACAAGGCCTTCG
GACCAGAATTGAGAGAGGAATT
TTCTAAACTCCAGAACAAGACCAAGCTGACAGTGCTG
GAAGGAGACATTCTGGATGAGCCATTCCTGAAG
AGAGCCTGCCAGGACGTCTCGGTCAT
CATCCACACCGCCTGTATCATTGATGTCTTCGGTGTCACTCACA
GAGAGTCTATCATGA
ATGTCAATGTGAAAGGTACCCAGCTCCTGTTAGAGGCCTGTGTCCAAGCTAGTGT
GCCA
GTCTTCATCTACACCAGTAGCATAGAGGTAGCCGGGCCCAACTCCTACAAGGAAATCATC
CAGAAT
GGCCATGAAGAAGAGCCTCTGGAAAACACATGGCCCGCTCCATACCCACACAG
CAAAAAGCTTGCTGAGA
AGGCTGTACTGGCGGCTAACGGGTGGAATCTGAAAAACGGCG
GCACCCTGTACACTTGTGCCTTACGACC
CATGTATATCTATGGGGAAGGAAGCCGATTC
CTTTCTGCTAGTATAAACGAGGCCCTGAACAACAATGGG
ATCCTGTCAAGTGTTGGAAA
GTTCTCCACTGTTAACCCAGTCTATGTTGGCAATGTGGCCTGGGCCCACA
TTCTGGCCT
TGAGGGCCCTGCAGGACCCCAAGAAGGCCCCAAGCATCCGAGGACAGTTCTACTATATCT
C
AGATGACACGCCTCACCAAAGCTATGATAACCTTAATTACACCCTGAGCAAAGAGTTC
GGCCTCCGCCTT
GATTCCAGATGGAGCTTTCCTTTATCCCTGATGTATTGGATTGGCTT
CCTGCTGGAAATAGTGAGCTTCC
TACTCAGGCCAATTTACACCTATCGACCGCCCTTCA
ACCGCCACATAGTCACATTGTCAAATAGCGTATT
CACCTTCTCTTATAAGAAGGCTCAG
CGAGATCTGGCGTATAAGCCACTCTACAGCTGGGAGGAAGCCAAG
CAGAAAACGGTGGA
GTGGGTTGGTTCCCTTGTGGACCGGCACAAGGAGACCCTGAAGTCCAAGACTCAGT
GA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M27137

# Metabolic_Enzyme_4_Chromosome_Location:
Not Available

# Metabolic_Enzyme_4_Locus:
Not Available

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
2779585; 2139411; 2082186; 2243100; 1920284; 1401999; 10391209

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5591

# Metabolic_Enzyme_5_Name:
Sulfotransferase family cytosolic 2B member 1

# Metabolic_Enzyme_5_Synonyms:
Sulfotransferase 2B1; Alcohol sulfotransferase; Hydroxysteroid sulfotransferase 2

# Metabolic_Enzyme_5_Gene_Name:
SULT2B1

# Metabolic_Enzyme_5_Protein_Sequence:
>Sulfotransferase family cytosolic 2B member 1
MDGPAEPQIPGLWDTYEDDISEISQKLPGEYFRYKGVPFPVGLYSLESISLAENTQDVRD
DDIFIITYPK
SGTTWMIEIICLILKEGDPSWIRSVPIWERAPWCETIVGAFSLPDQYSP
RLMSSHLPIQIFTKAFFSSKA
KVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLRD
FLKGEVQFGSWFDHIKGWLRMKGKDNFLFITY
EELQQDLQGSVERICGFLGRPLGKEAL
GSVVAHSTFSAMKANTMSNYTLLPPSLLDHRRGAFLRKGVCGD
WKNHFTVAQSEAFDRA
YRKQMRGMPTFPWDEDPEEDGSPDPEPSPEPEPKPSLEPNTSLEREPRPNSSPS
PSPGQ
ASETPHPRPS

# Metabolic_Enzyme_5_Number_of_Residues:
365

# Metabolic_Enzyme_5_Molecular_Weight:
41308

# Metabolic_Enzyme_5_Theoretical_pI:
5.05

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol

# Metabolic_Enzyme_5_Pathway:
map00150  Androgen and estrogen metabolism;
 map00920  Sulfur metabolism

# Metabolic_Enzyme_5_Reaction:
3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.8.2.2

# Metabolic_Enzyme_5_GenBank_ID_Protein:
1923291

# Metabolic_Enzyme_5_SwissProt_ID:
ST2B1_HUMAN (O00204)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
SULT2B1

# Metabolic_Enzyme_5_Geneatlas_id:
SULT2B1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:11459

# Metabolic_Enzyme_5_PDB_ID:
1Q1Q

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1053 bp

ATGGCGTCTCCCCCACCTTTCCACAGCCAGAAGTTGCCAGGTGAATACTTCCGGTACAA
GGGCGTCCCCT
TCCCCGTCGGCCTGTACTCGCTCGAGAGCATCAGCTTGGCGGAGAACA
CCCAAGATGTGCGGGACGACGA
CATCTTTATCATCACCTACCCCAAGTCAGGCACGACC
TGGATGATCGAGATCATCTGCTTAATCCTGAAG
GAAGGGGATCCATCCTGGATCCGCTC
CGTGCCCATCTGGGAGCGGGCACCCTGGTGTGAGACCATTGTGG
GTGCTTTCAGCCTCC
CGGACCAGTACAGCCCCCGCCTCATGAGCTCCCATCTTCCCATCCAGATCTTCAC
CAAG
GCCTTCTTCAGCTCCAAGGCCAAGGTGATCTACATGGGCCGCAACCCCCGGGACGTTGTG
GTCTCC
CTCTATCATTACTCCAAGATCGCCGGGCAGTTAAAGGACCCGGGCACACCCGA
CCAGTTCCTGAGGGACT
TCCTCAAAGGCGAAGTGCAGTTTGGCTCCTGGTTCGACCACA
TTAAGGGCTGGCTTCGGATGAAGGGCAA
AGACAACTTCCTATTTATCACCTACGAGGAG
CTGCAGCAGGACTTACAGGGCTCCGTGGAGCGCATCTGT
GGGTTCCTGGGCCGTCCGCT
GGGCAAGGAGGCACTGGGCTCCGTCGTGGCACACTCAACCTTCAGCGCCA
TGAAGGCCA
ACACCATGTCCAACTACACGCTGCTGCCTCCCAGCCTGCTGGACCACCGTCGCGGGGCCT
T
CCTCCGGAAAGGGGTCTGCGGCGACTGGAAGAACCACTTCACGGTGGCCCAGAGCGAA
GCCTTCGATCGT
GCCTACCGCAAGCAGATGCGGGGGATGCCGACCTTCCCCTGGGATGA
AGACCCGGAGGAGGATGGCAGCC
CAGATCCTGAGCCCAGCCCTGAGCCTGAGCCCAAGC
CCAGCCTTGAGCCCAACACCAGCCTGGAGCGTGA
GCCCAGACCCAACTCCAGCCCCAAC
CCCAGCCCCGGCCAGGCCTCTGAGACCCCGCACCCACGACCCTCA
TAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U92314

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_5_Locus:
19q13.3

# Metabolic_Enzyme_5_SNPs:
rs2302947; rs2544794; rs1132054; rs2302948; rs1052131; rs2431141; rs3815691; rs12460535; rs4149455; rs2544789; rs10416980; rs3760802; rs3760800; rs8109054; rs2544788; rs10424976; rs8109050; rs4802489; rs11083943; rs2544785; rs6509396; rs2544784; rs10426377; rs175924; rs2544783; rs8108904; rs3745726; rs3848542; rs12611137; rs2544787; rs4802495; rs11672175; rs4801764; rs11880293; rs4080470; rs10417472; rs10401347; rs8108022; rs11880831; rs4149456; rs10425691; rs2665601; rs11882923; rs11083944; rs10420140; rs12462337; rs2544786; rs6509393; rs2665605; rs11881295; rs7248376; rs10426193; rs2544800; rs6509397; rs10425172; rs7249780; rs3760808; rs4801766; rs10420172; rs10424445; rs2665586; rs10418193; rs2665580; rs4080469; rs3760804; rs12611168; rs10424655; rs4802490; rs8109679; rs12462087; rs8106759; rs2665583; rs9304677; rs7249118; rs3909296; rs6509392; rs3826827; rs10424237; rs4802491; rs10418222; rs12981320; rs12608902; rs2665606; rs8111787; rs11878385; rs11880848; rs6509394; rs2665584; rs12976976; rs7409348; rs2379081; rs2544793; rs3760805; rs7408540; rs12611151; rs4801768; rs2665582; rs34373168; rs8112135; rs6509391; rs12611128; rs12610737; rs11882607; rs11083946; rs2665577; rs10426563; rs3786749; rs7248627; rs2665587; rs3786750; rs2665581; rs10415318; rs12611192; rs4801765; rs9676424; rs3909295; rs10404801; rs11882405; rs2302949; rs11083945; rs2544795; rs9676516; rs12977025; rs7258739; rs12975397; rs10426628; rs2544790; rs2379085; rs7246557; rs7255533; rs9973264; rs11666506; rs13347093; rs2665600; rs2544804; rs10422117; rs8107786; rs2246836; rs10419482; rs9676485; rs12460513; rs8108917; rs8108812; rs7257121; rs2665604; rs12981299; rs12981760; rs10403171; rs10420304; rs2665579; rs10422717; rs12608918; rs8107219; rs11878647; rs2665575; rs12977008; rs12611181; rs8100256; rs3815692; rs8103525; rs6509395; rs11083942; rs10416165; rs11672291; rs279447; rs2246837; rs3859437; rs2665603; rs11671705; rs2665574; rs10420892; rs2665602; rs12611119; rs2544801; rs11882293; rs10416119; rs8113355; rs10410524; rs12609189; rs279449; rs11878685; rs1052124; rs5828356; rs11286832; rs2544799; rs34578466; rs10589655; rs11083941; rs2544802; rs34808712; rs35790289; rs2544792; rs10648968; rs34429366; rs10427068; rs34768198; rs279446; rs12980918; rs28626601; rs9676509; rs10407019; rs34332722; rs2665576; rs34698909; rs35448535; rs10577756; rs11878722; rs8104499; rs36003772; rs2544782; rs34741298; rs3837954; rs10411546; rs34625801; rs2544796; rs3859438; rs2941502; rs2544798; rs9676465; rs7259869; rs2544803; rs10421116; rs34399820; rs35503043; rs9789258; rs10411304; rs2665596; rs11285675; rs35536990; rs10581692; rs11881377; rs9789261; rs4802492; rs8108788; rs2544791; rs2544781; rs34482710; rs35921662; rs2379089; rs35197699; rs2379082; rs34353616; rs8109498; rs9676529; rs28446557; rs4011542; rs12983435; rs11666287; rs35450632; rs10417160; rs7259862; rs13343592; rs35211958; rs2665597; rs11671834; rs279445; rs10423750; rs34345412; rs35813972; rs10402100; rs3760806; rs3833253; rs10426286; rs12974007; rs3760801; rs28411253; rs35375190; rs34154386; rs35544342; rs34107488; rs2665578; rs12104307; rs2665599; rs10408348; rs35172026; rs10668221; rs35747850; rs34522310; rs7256244; rs35749262; rs10424430; rs34520151; rs12981151; rs36088037; rs35221052; rs5828354; rs34704123; rs35905762; rs2665590; rs28439983; rs2665585; rs3843745; rs34512399; rs12976785; rs2665608; rs10425879; rs28370904; rs11879142; rs4801767; rs34945864; rs10407495; rs3760807; rs2379083; rs12979357; rs11882313; rs2544797; rs11668970; rs36014830; rs5828355; rs3893696; rs11453549; rs2890071; rs34812578; rs28366580; rs2665598; rs12979991; rs10552230; rs35186872; rs10549281; rs10405920; rs2665607; rs34974937; rs34230215; rs10427087; rs34886384; rs3760803; rs35280795; rs11880900; rs2379084; rs35679165; rs34813342; rs10415492; rs35078110; rs28759208; rs8108153; rs2665588; rs12980615; rs3837955; rs34622126; rs10639250; rs279448; rs10415861; rs279450; rs10413911; rs1236093; rs12460223; rs12611321; rs12981419; rs16982137; rs16982149; rs16982159; rs17842463; rs2544808; rs2617805; rs2665591; rs2665593; rs279451; rs279452; rs34439264; rs3745727; rs378333; rs402209; rs411482; rs9807810

# Metabolic_Enzyme_5_General_References:
9799594; 12145317; 12923182

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5565

# Metabolic_Enzyme_6_Name:
GDH/6PGL endoplasmic bifunctional protein precursor [Includes: Glucose 1-dehydrogenase

# Metabolic_Enzyme_6_Synonyms:
Hexose-6-phosphate dehydrogenase; 6- phosphogluconolactonase; 6PGL]

# Metabolic_Enzyme_6_Gene_Name:
H6PD

# Metabolic_Enzyme_6_Protein_Sequence:
>GDH/6PGL endoplasmic bifunctional protein precursor Includes: Glucose 1dehydrogenase
MWNMLIVAMCLALLGCLQAQELQGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGRGHSF
SFHGAALTAPKQGQELMAKALESLSCPKDMAPSHCAEHKDQFLQLSQYRQLKTAEDYQAL
NKDIEAQLQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDH
FSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDGLWNRHHVERVEII
MKETVDAEGRTSFYEEYGVIRDVLQNHLTEVLTLVAMELPHNVSSAEAVLRHKLQVFQAL
RGLQRGSAVVGQYQSYSEQVRRELQKPDSFHSLTPTFAAVLVHIDNLRWEGVPFILMSGK
ALDERVGYARILFKNQACCVQSEKHWAAAQSQCLPRQLVFHIGHGDLGSPAVLVSRNLFR
PSLPSSWKEMEGPPGLRLFGSPLSDYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLL
ASWNFWTPLLESLAHKAPRLYPGGAENGRLLDFEFSSGRLFFSQQQPEQLVPGPGPAPMP
SDFQVLRAKYRESPLVSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQ
QLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHLLQHVRIPYYNIHPMPVHLQQ
RLCAEEDQGAQIYAREISALVANSSFDLVLLGMGADGHTASLFPQSPTGLDGEQLVVLTT
SPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLPHSGQL
VWYMDYDAFLG

# Metabolic_Enzyme_6_Number_of_Residues:
791

# Metabolic_Enzyme_6_Molecular_Weight:
88894

# Metabolic_Enzyme_6_Theoretical_pI:
7.31

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  6-phosphogluconolactonase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  glucose-6-phosphate 1-dehydrogenase activity
 ||
>>>
Process:  glucose catabolism
Process:  pentose-phosphate shunt
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates

# Metabolic_Enzyme_6_Pathway:
map00030  Pentose phosphate pathway

# Metabolic_Enzyme_6_Reaction:
6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF02781:G6PD_C;
PF00479:G6PD_N;
PF01182:Glucosamine_iso

# Metabolic_Enzyme_6_Signals:
1-19

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.1.1.47;EC 3.1.1.31

# Metabolic_Enzyme_6_GenBank_ID_Protein:
4186038

# Metabolic_Enzyme_6_SwissProt_ID:
G6PE_HUMAN (O95479)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
H6PD

# Metabolic_Enzyme_6_Geneatlas_id:
H6PD

# Metabolic_Enzyme_6_hgnc_id:
HGNC:4795

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum lumen. Note=Microsomes, endoplasmic reticulum lumen

# Metabolic_Enzyme_6_Gene_Sequence:
>2376 bp
ATGTGGAATATGCTCATAGTGGCGATGTGCTTGGCCCTTCTGGGCTGCCTGCAAGCCCAG
GAGCTCCAGGGACATGTCTCCATAATCCTGCTGGGAGCAACTGGGGACCTGGCTAAGAAG
TACTTATGGCAGGGACTGTTCCAGCTGTACCTGGATGAAGCGGGGAGGGGTCACAGTTTT
AGCTTCCATGGAGCTGCTCTGACAGCCCCCAAGCAGGGTCAAGAGCTCATGGCCAAGGCC
CTGGAATCCCTCTCCTGCCCCAAGGACATGGCACCCAGTCACTGTGCAGAGCACAAGGAT
CAGTTCCTGCAGCTGAGCCAGTACCGCCAACTGAAGACGGCCGAGGACTATCAGGCCCTG
AACAAGGACATCGAGGCACAGCTCCAGCACGCAGGCCTCCGGGAGGCTGGCAGGATCTTC
TACTTCTCAGTGCCACCCTTCGCCTATGAAGACATTGCCCGCAACATCAACAGTAGCTGC
CGGCCAGGCCCGGGCGCCTGGCTGCGGGTTGTCCTTGAGAAACCCTTTGGCCATGACCAC
TTCTCAGCCCAGCAGCTGGCCACAGAACTCGGGACCTTTTTCCAGGAGGAGGAGATGTAC
CGGGTGGACCATTACTTAGGCAAGCAGGCTGTGGCGCAGATCCTGCCTTTCCGAGACCAG
AACCGCAAGGCTTTGGACGGCCTCTGGAACCGGCACCATGTGGAGCGGGTGGAGATCATC
ATGAAAGAGACCGTGGATGCTGAAGGCCGCACCAGCTTCTATGAGGAGTACGGTGTCATT
CGCGACGTCCTCCAGAACCATCTGACGGAGGTCCTCACCCTCGTGGCCATGGAGCTGCCC
CACAATGTCAGCAGTGCGGAGGCTGTGCTGCGGCACAAGCTTCAGGTCTTCCAGGCGCTG
CGGGGCCTGCAGAGGGGCAGTGCCGTCGTGGGCCAGTACCAGTCTTACAGTGAGCAGGTG
CGCAGAGAGCTGCAGAAGCCAGACAGCTTCCACAGCCTGACGCCGACCTTCGCAGGTGTC
CTAGTGCACATTGACAACCTTCGCTGGGAGGGCGTGCCTTTCATCCTGATGTCTGGCAAA
GCCTTGGACGAGAGAGTGGGCTACGCTCGGATCTTGTTCAAGAACCAGGCCTGCTGTGTG
CAGAGCGAAAAGCACTGGGCCGCGGCGCAGAGCCAGTGCCTGCCCCGGCAGCTCGTCTTC
CACATCGGCCATGGCGACCTGGGCAGCCCTGCCGTGCTGGTCAGCAGGAACCTGTTCAGG
CCCTCCCTGCCCTCCAGCTGGAAGGAAATGGAGGGACCACCTGGGCTCCGCCTTTTCGGC
AGCCCTCTGTCCGATTACTACGCCTACAGCCCTGTGCGGGAGCGGGACGCCCACTCCGTC
CTCTTATCCCATATCTTCCATGGCCGGAAGAATTTCTTCATCACCACAGAGAACTTGCTG
GCCTCCTGGAACTTCTGGACCCCTCTGCTGGAGAGCCTGGCCCATAAGGCCCCACGCCTC
TACCCTGGAGGAGCTGAGAATGGCCGTCTGTTGGACTTTGAGTTCAGTAGCGGCCGGTTG
TTCTTTTCCCAGCAGCAGCCGGAGCAGCTGGTGCCAGGGCCAGGGCCGGCCCCAATGCCC
AGTGACTTCCAGGTCCTCAGGGCCAAGTACCGAGAGAGCCCGCTGGTCTCCGCCTGGTCC
GAGGAGCTGATCTCTAAGCTGGCTAATGACATCGAGGCCACCGCTGTGCGAGCCGTGCGG
CGCTTTGGCCAGTTCCACCTGGCACTGTCGGGGGGCTCGAGCCCCGTGGCCCTGTTCCAG
CAGCTGGCCACGGCGCACTATGGCTTCCCCTGGGCCCACACGCACCTGTGGCTGGTTGAC
GAGCGCTGCGTCCCACTCTCAGACCCGGAGTCCAACTTCCAGGGCCTGCAGGCCCACCTG
CTGCAGCACGTCCGGATCCCCTACTACAACATCCACCCCATGCCTGTGCACCTGCAGCAG
CGGCTCTGCGCCGAGGAGGACCAGGGCGCCCAGATCTATGCCAGGGAGATCTCAGCCCTG
GTGGCCAACAGCAGCTTCGACCTGGTGCTGCTGGGCATGGGTGCCGACGGGCACACAGCC
TCCCTCTTCCCACAGTCACCCACTGGCCTGGATGGCGAGCAGCTGGTCGTGCTGACCACG
AGCCCCTCCCAGCCACACCGCCGCATGAGCCTTAGCCTGCCTCTCATCAACCGCGCCAAG
AAGGTGGCAGTCCTGGTCATGGGCAGGATGAAGCGTGAGATCACCACGCTGGTGAGCCGG
GTGGGCCATGAGCCCAAGAAGTGGCCCATCTCGGGTGTCCTGCCGCACTCCGGCCAGCTG
GTGTGGTACATGGACTACGACGCCTTCCTGGGATGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AJ012590

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_6_Locus:
1p36

# Metabolic_Enzyme_6_SNPs:
rs6688832; rs17368528; rs35404275; rs34603401; rs35525021; rs7524046; rs9434743; rs9434742; rs11121350; rs35301166; rs1294014; rs11807816; rs2268175; rs12314; rs1294015; rs2239561; rs2268176; rs11121354; rs11121356; rs17368633; rs11121355; rs2268173; rs2071931; rs9434747; rs17033642; rs1142687; rs11121349; rs12405956; rs6685399; rs4908830; rs1294011; rs9434745; rs9435159; rs9434729; rs12126056; rs2268172; rs11588606; rs1142672; rs2239560; rs732950; rs731183; rs3753165; rs1294010; rs3753164; rs2268169; rs3753163; rs2268170; rs6662509; rs11804534; rs763180; rs11809790; rs2310925; rs10864404; rs2311051; rs11806000; rs3765959; rs10864403; rs12082862; rs7526864; rs9435151; rs7514387; rs6577564; rs11801562; rs9434725; rs7522207; rs35610691; rs34274595; rs12118991; rs35668164; rs17368556; rs35511555; rs34580447; rs35863691; rs7412488; rs36094664; rs34082738; rs34448374; rs36058755; rs3207298; rs33954071; rs3207317; rs3752547; rs5772361; rs41280760; rs9434726; rs35833857; rs12728837; rs4908831; rs1065216; rs3207316; rs3057978; rs11588618; rs35071335; rs41280764; rs9435162; rs2268174; rs9435144; rs35341128; rs34967254; rs9435148; rs34715803; rs1142686; rs1142671; rs9435161; rs1138467; rs12144045; rs34078161; rs12403063; rs1138468; rs1142675; rs35486518; rs3206225; rs1142689; rs9435163; rs6697931; rs1294016; rs35600947; rs9434746; rs41280762; rs2268171; rs6658895; rs12040818; rs1142688; rs9435164; rs1142690; rs34854341; rs9434737; rs36065021; rs1294009; rs5772359; rs12039626; rs9435158; rs1890684; rs34931714; rs12076525; rs2097519; rs763179; rs28548609; rs28665681; rs34308839; rs12083129; rs10449320; rs3861753; rs9434736; rs12032814; rs11805951; rs9435152; rs34764359; rs28496367; rs35492379; rs9435156; rs9434732; rs11804519; rs3765958; rs5772358; rs9435155; rs12042692; rs9434738; rs743972; rs35063052; rs12039625; rs2185298; rs12738271; rs2095907; rs4601607; rs34149245; rs6680990; rs9435167; rs9435166; rs7523498; rs35587892; rs7523400; rs1003369; rs1004920; rs10489436; rs10746487; rs11590326; rs12072683; rs12093524; rs12093571; rs12403829; rs1294012; rs2097520; rs2105225; rs2871656; rs34870859; rs3753271; rs4908832; rs6688233; rs7517538; rs916379; rs916380; rs916381; rs916382; rs916383; rs916384; rs916385; rs916386; rs9434723; rs9435168; rs9435179; rs946599; rs946602

# Metabolic_Enzyme_6_General_References:
10349511

# Metabolic_Enzyme_6_References:
12234842; 12241078; 15177053; 15613680

# Metabolic_Enzyme_7_ID:
6214

# Metabolic_Enzyme_7_Name:
Nitric oxide synthase, inducible

# Metabolic_Enzyme_7_Synonyms:
NOS type II; Inducible NO synthase; Inducible NOS; iNOS; Hepatocyte NOS; HEP- NOS

# Metabolic_Enzyme_7_Gene_Name:
NOS2A

# Metabolic_Enzyme_7_Protein_Sequence:
>Nitric oxide synthase, inducible
MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPL
VETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIM
TPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ
LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNI
RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG
RFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVG
GLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINI
AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEM
LNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVT
ILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPG
NGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGD
ELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDL
SKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQ
PALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQ
LLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQL
PILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCF
VRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPD
EDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLY
VCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDR
VAVQPSSLEMSAL

# Metabolic_Enzyme_7_Number_of_Residues:
1153

# Metabolic_Enzyme_7_Molecular_Weight:
131119

# Metabolic_Enzyme_7_Theoretical_pI:
8.01

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  cofactor binding
Function:  coenzyme binding
Function:  NADP binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  FAD binding
Function:  tetrapyrrole binding
Function:  heme binding
Function:  protein binding
Function:  calmodulin binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  monooxygenase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen
Function:  nitric-oxide synthase activity
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
Function:  transporter activity
Function:  electron transporter activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  biosynthesis
Process:  nitric oxide biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions

# Metabolic_Enzyme_7_Pathway:
map00330  Arginine and proline metabolism

# Metabolic_Enzyme_7_Reaction:
L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00667:FAD_binding_1;
PF00258:Flavodoxin_1;
PF00175:NAD_binding_1;
PF02898:NO_synthase

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.14.13.39

# Metabolic_Enzyme_7_GenBank_ID_Protein:
292242

# Metabolic_Enzyme_7_SwissProt_ID:
NOS2A_HUMAN (P35228)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
NOS2A

# Metabolic_Enzyme_7_Geneatlas_id:
NOS2A

# Metabolic_Enzyme_7_hgnc_id:
HGNC:7873

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>3462 bp
ATGGCCTGTCCTTGGAAATTTCTGTTCAAGACCAAATTCCACCAGTATGCAATGAATGGG
GAAAAAGACATCAACAACAATGTGGAGAAAGCCCCCTGTGCCACCTCCAGTCCAGTGACA
CAGGATGACCTTCAGTATCACAACCTCAGCAAGCAGCAGAATGAGTCCCCGCAGCCCCTC
GTGGAGACGGGAAAGAAGTCTCCAGAATCTCTGGTCAAGCTGGATGCAACCCCATTGTCC
TCCCCACGGCATGTGAGGATCAAAAACTGGGGCAGCGGGATGACTTTCCAAGACACACTT
CACCATAAGGCCAAAGGGATTTTAACTTGCAGGTCCAAATCTTGCCTGGGGTCCATTATG
ACTCCCAAAAGTTTGACCAGAGGACCCAGGGACAAGCCTACCCCTCCAGATGAGCTTCTA
CCTCAAGCTATCGAATTTGTCAACCAATATTACGGCTCCTTCAAAGAGGCAAAAATAGAG
GAACATCTGGCCAGGGTGGAAGCGGTAACAAAGGAGATAGAAACAACAGGAACCTACCAA
CTGACGGGAGATGAGCTCATCTTCGCCACCAAGCAGGCCTGGCGCAATGCCCCACGCTGC
ATTGGGAGGATCCAGTGGTCCAACCTGCAGGTCTTCGATGCCCGCAGCTGTTCCACTGCC
CGGGAAATGTTTGAACACATCTGCAGACACGTGCGTTACTCCACCAACAATGGCAACATC
AGGTCGGCCATCACCGTGTTCCCCCAGCGGAGTGATGGCAAGCACGACTTCCGGGTGTGG
AATGCTCAGCTCATCCGCTATGCTGGCTACCAGATGCCAGATGGCAGCATCAGAGGGGAC
CCTGCCAACGTGGAATTCACTCAGCTGTGCATCGACCTGGGCTGGAAGCCCAAGTACGGC
CGCTTCGATGTGGTCCCCCTGGTCCTGCAGGCCAATGGCCGTGACCCTGAGCTCTTCGAA
ATCCCACCTGACCTTGTGCTTGAGGTGGCCATGGAACATCCCAAATACGAGTGGTTTCGG
GAACTGGAGCTAAAGTGGTACGCCCTGCCTGCAGTGGCCAACATGCTGCTTGAGGTGGGC
GGCCTGGAGTTCCCAGGGTGCCCCTTCAATGGCTGGTACATGGGCACAGAGATCGGAGTC
CGGGACTTCTGTGACGTCCAGCGCTACAACATCCTGGAGGAAGTGGGCAGGAGAATGGGC
CTGGAAACGCACAAGCTGGCCTCGCTCTGGAAAGACCAGGCTGTCGTTGAGATCAACATT
GCTGTGATCCATAGTTTTCAGAAGCAGAATGTGACCATCATGGACCACCACTCGGCTGCA
GAATCCTTCATGAAGTACATGCAGAATGAATACCGGTCCCGTGGGGGCTGCCCGGCAGAC
TGGATTTGGCTGGTCCCTCCCATGTCTGGGAGCATCACCCCCGTGTTTCACCAGGAGATG
CTGAACTACGTCCTGTCCCCTTTCTACTACTATCAGGTAGAGGCCTGGAAAACCCATGTC
TGGCAGGACGAGAAGCGGAGACCCAAGAGAAGAGAGATTCCATTGAAAGTCTTGGTCAAA
GCTGTGCTCTTTGCCTGTATGCTGATGCGCAAGACAATGGCGTCCCGAGTCAGAGTCACC
ATCCTCTTTGCGACAGAGACAGGAAAATCAGAGGCGCTGGCCTGGGACCTGGGGGCCTTA
TTCAGCTGTGCCTTCAACCCCAAGGTTGTCTGCATGGATAAGTACAGGCTGAGCTGCCTG
GAGGAGGAACGGCTGCTGTTGGTGGTGACCAGTACGTTTGGCAATGGAGACTGCCCTGGC
AATGGAGAGAAACTGAAGAAATCGCTCTTCATGCTGAAAGAGCTCAACAACAAATTCAGG
TACGCTGTGTTTGGCCTCGGCTCCAGCATGTACCCTCGGTTCTGCGCCTTTGCTCATGAC
ATTGATCAGAAGCTGTCCCACCTGGGGGCCTCTCAGCTCACCCCGATGGGAGAAGGGGAT
GAGCTCAGTGGGCAGGAGGACGCCTTCCGCAGCTGGGCCGTGCAAACCTTCAAGGCAGCC
TGTGAGACGTTTGATGTCCGAGGCAAACAGCACATTCAGATCCCCAAGCTCTACACCTCC
AATGTGACCTGGGACCCGCACCACTACAGGCTCGTGCAGGACTCACAGCCTTTGGACCTC
AGCAAAGCCCTCAGCAGCATGCATGCCAAGAACGTGTTCACCATGAGGCTCAAATCTCGG
CAGAATCTACAAAGTCCGACATCCAGCCGTGCCACCATCCTGGTGGAACTCTCCTGTGAG
GATGGCCAAGGCCTGAACTACCTGCCGGGGGAGCACCTTGGGGTTTGCCCAGGCAACCAG
CCGGCCCTGGTCCAAGGCATCCTGGAGCGAGTGGTGGATGGCCCCACACCCCACCAGACA
GTGCGCCTGGAGGACCTGGATGAGAGTGGCAGCTACTGGGTCAGTGACAAGAGGCTGCCC
CCCTGCTCACTCAGCCAGGCCCTCACCTACTCCCCGGACATCACCACACCCCCAACCCAG
CTGCTGCTCCAAAAGCTGGCCCAGGTGGCCACAGAAGAGCCTGAGAGACAGAGGCTGGAG
GCCCTGTGCCAGCCCTCAGAGTACAGCAAGTGGAAGTTCACCAACAGCCCCACATTCCTG
GAGGTGCTAGAGGAGTTCCCGTCCCTGCGGGTGTCTGCTGGCTTCCTGCTTTCCCAGCTC
CCCATTCTGAAGCCCAGGTTCTACTCCATCAGCTCCTCCCGGGATCACACGCCCACGGAG
ATCCACCTGACTGTGGCCGTGGTCACCTACCACACCGGAGATGGCCAGGGTCCCCTGCAC
CACGGTGTCTGCAGCACATGGCTCAACAGCCTGAAGCCCCAAGACCCAGTGCCCTGCTTT
GTGCGGAATGCCAGCGCCTTCCACCTCCCCGAGGATCCCTCCCATCCTTGCATCCTCATC
GGGCCTGGCACAGGCATCGTGCCCTTCCGCAGTTTCTGGCAGCAACGGCTCCATGACTCC
CAGCACAAGGGAGTGCGGGGAGGCCGCATGACCTTGGTGTTTGGGTGCCGCCGCCCAGAT
GAGGACCACATCTACCAGGAGGAGATGCTGGAGATGGCCCAGAAGGGGGTGCTGCATGCG
GTGCACACAGCCTATTCCCGCCTGCCTGGCAAGCCCAAGGTCTATGTTCAGGACATCCTG
CGGCAGCAGCTGGCCAGCGAGGTGCTCCGTGTGCTCCACAAGGAGCCAGGCCACCTCTAT
GTTTGCGGGGATGTGCGCATGGCCCGGGACGTGGCCCACACCCTGAAGCAGCTGGTGGCT
GCCAAGCTGAAATTGAATGAGGAGCAGGTCGAGGACTATTTCTTTCAGCTCAAGAGCCAG
AAGCGCTATCACGAAGATATCTTCGGTGCTGTATTTCCTTACGAGGCGAAGAAGGACAGG
GTGGCGGTGCAGCCCAGCAGCCTGGAGATGTCAGCGCTCTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
L09210

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_7_Locus:
17q11.2-q12

# Metabolic_Enzyme_7_SNPs:
rs3730017; rs2297518; rs3729662; rs3730014; rs1137933; rs28999412; rs16966563; rs28730832; rs1060826; rs1060822; rs10459953; rs3730013; rs6505483; rs28998796; rs15782; rs28998799; rs3201742; rs28998798; rs2872753; rs944725; rs2314809; rs4795067; rs2297512; rs944724; rs9895831; rs3794763; rs3729966; rs4239250; rs8068149; rs3729508; rs4796052; rs944722; rs2297520; rs9904158; rs9797244; rs7208775; rs11080344; rs3729718; rs3794764; rs28450000; rs8080418; rs2297515; rs2297514; rs3730228; rs2297517; rs8065448; rs3794767; rs3794759; rs8070472; rs12452167; rs944723; rs17722851; rs3794756; rs4796040; rs2297511; rs3794765; rs4796034; rs8072199; rs10853180; rs2297510; rs3729507; rs16966545; rs2297513; rs8073631; rs9895453; rs17718148; rs2274894; rs7217335; rs3729719; rs2072324; rs2314812; rs3729720; rs3729727; rs2297516; rs8065817; rs3794766; rs8067880; rs3730234; rs9282801; rs9282800; rs3729661; rs4796080; rs2248814; rs6505445; rs9906835; rs9906122; rs28942375; rs11653716; rs3730232; rs1113283; rs28944194; rs28999408; rs3794761; rs8067177; rs28999370; rs41353546; rs28944186; rs2314813; rs11871315; rs28998815; rs6505469; rs28999387; rs28662210; rs28944196; rs28998832; rs28942968; rs28999414; rs28944190; rs28998809; rs28999393; rs28942373; rs16949; rs28944178; rs28999401; rs28998802; rs28999394; rs28944211; rs7213691; rs28998818; rs28998804; rs28944206; rs28998821; rs28944208; rs28998812; rs28944197; rs28999391; rs28999385; rs28944181; rs28999374; rs28998828; rs28999413; rs28999398; rs28998814; rs11870951; rs11871150; rs28998808; rs28944177; rs28998817; rs28999400; rs28944213; rs11657646; rs28999409; rs28942372; rs28999380; rs28998826; rs9890954; rs28942370; rs2255929; rs4796038; rs28944180; rs28998831; rs28944198; rs28999405; rs28942368; rs28944169; rs28999384; rs28944182; rs28999377; rs28998807; rs28998805; rs28944205; rs28998822; rs28999399; rs28944195; rs1962380; rs28944209; rs28944192; rs28999375; rs28944193; rs2314810; rs28999383; rs28999390; rs28999410; rs2779248; rs7406657; rs12450521; rs2779249; rs8081248; rs8078340; rs28943568; rs28944221; rs1800482; rs28998792; rs28944230; rs28998790; rs28944231; rs28944218; rs28973255; rs28944222; rs28944229; rs28944224; rs9282799; rs11080321; rs28998795; rs28944227; rs4795055; rs4796029; rs28944232; rs28944220; rs2314808; rs3730230; rs28944201; rs3729717; rs28944173; rs28999379; rs34719207; rs28944168; rs1137949; rs1060828; rs7223110; rs28944200; rs28944214; rs35834812; rs7359686; rs28998800; rs12453234; rs28944216; rs7359651; rs28998797; rs28944215; rs28944217; rs34749068; rs3794757; rs16948; rs34293265; rs28999411; rs41337547; rs28999396; rs28944202; rs34641676; rs3730231; rs28999403; rs7502274; rs4796055; rs10557822; rs28999368; rs9895077; rs34975273; rs28942378; rs28999407; rs28999372; rs3751971; rs9282802; rs28944171; rs34931287; rs35370851; rs28998816; rs28942369; rs28998825; rs28944184; rs28944212; rs11363739; rs28999404; rs34972969; rs28944176; rs28999376; rs28999415; rs28942379; rs28998811; rs11363740; rs28998827; rs41449853; rs28942376; rs35659482; rs3730015; rs28944185; rs28944188; rs28944191; rs28944172; rs28944174; rs10569534; rs28944179; rs28722995; rs3838879; rs28999371; rs28999389; rs28999382; rs28942374; rs28999397; rs34658875; rs7222398; rs28944170; rs28999416; rs3838880; rs28944183; rs28998824; rs4796041; rs41323846; rs28999386; rs28999378; rs28999406; rs34992777; rs28998829; rs28998833; rs3794760; rs28999373; rs35214201; rs28998810; rs3833855; rs28998806; rs28944189; rs34069634; rs28998803; rs28999369; rs28998830; rs41513847; rs28998823; rs12950084; rs28944199; rs28944203; rs35561933; rs11428460; rs34388532; rs5819821; rs35660190; rs35051118; rs28998813; rs35395276; rs28999392; rs28942377; rs34237194; rs28998801; rs3730016; rs28999395; rs28942371; rs3794758; rs11655101; rs28944210; rs28998819; rs34147660; rs28944175; rs28944207; rs10657353; rs28730831; rs3838881; rs28999388; rs28999402; rs28999381; rs28999417; rs28944187; rs34921306; rs3730229; rs28998820; rs28944223; rs28998794; rs35009352; rs28944228; rs34709845; rs28943570; rs28944226; rs1799765; rs28998793; rs28944233; rs28998791; rs28943569; rs28944225; rs28944219; rs12720460; rs28943571; rs34517795; rs11080358; rs12150211; rs12709500; rs16966425; rs2531860; rs2531861; rs2531862; rs2531863; rs2734299; rs2779251; rs2779252; rs2779253; rs2779254; rs2779255; rs4795050; rs4796018; rs4796028; rs7208420; rs7215373; rs8073782

# Metabolic_Enzyme_7_General_References:
7682706; 7692964; 7504305; 7522054; 7528017; 7531687; 7544004; 9160867; 7532248; 7558036; 9721329; 12080081; 10409685; 10074942

# Metabolic_Enzyme_7_References:
15175425; 16809378; 16836960

# Metabolic_Enzyme_8_ID:
5991

# Metabolic_Enzyme_8_Name:
Corticosteroid 11-beta-dehydrogenase isozyme 2

# Metabolic_Enzyme_8_Synonyms:
11-DH2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-beta-HSD2; NAD- dependent 11-beta-hydroxysteroid dehydrogenase

# Metabolic_Enzyme_8_Gene_Name:
HSD11B2

# Metabolic_Enzyme_8_Protein_Sequence:
>Corticosteroid 11betadehydrogenase isozyme 2
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV
LAAAGWIALS
RLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSP
GAIELRTCCSPRLRLLQMDLT
KPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAE
LSPVATFRSCMEVNFFGALELTKGLLPLLRSS
RGRIVTVGSPAGDMPYPCLGAYGTSKA
AVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRK
QLLLANLPQELLQAYG
KDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFI
HYYLP
EGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR

# Metabolic_Enzyme_8_Number_of_Residues:
405

# Metabolic_Enzyme_8_Molecular_Weight:
44127

# Metabolic_Enzyme_8_Theoretical_pI:
9.58

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids

# Metabolic_Enzyme_8_Pathway:
Not Available

# Metabolic_Enzyme_8_Reaction:
Not Available

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_8_Signals:
1-21

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.1.1.146

# Metabolic_Enzyme_8_GenBank_ID_Protein:
565082

# Metabolic_Enzyme_8_SwissProt_ID:
DHI2_HUMAN (P80365)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
HSD11B2

# Metabolic_Enzyme_8_Geneatlas_id:
HSD11B2

# Metabolic_Enzyme_8_hgnc_id:
HGNC:5209

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Microsome

# Metabolic_Enzyme_8_Gene_Sequence:
>1218 bp

ATGGAGCGCTGGCCTTGGCCGTCGGGCGGCGCCTGGCTGCTCGTGGCTGCCCGCGCGCT
GCTGCAGCTGC
TGCGCTCAGACCTGCGTCTGGGCCGCCCGCTGCTGGCGGCGCTGGCGC
TGCTGGCCGCGCTCGACTGGCT
GTGCCAGCGCCTGCTGCCCCCGCCGGCCGCACTCGCC
GTGCTGGCCGCCGCCGGCTGGATCGCGTTGTCC
CGCCTGGCGCGCCCGCAGCGCCTGCC
GGTGGCCACTCGCGCGGTGCTCATCACCGGCTGTGACTCTGGTT
TTGGCAAGGAGACGG
CCAAGAAACTGGACTCCATGGGCTTCACGGTGCTGGCCACCGTATTGGAGTTGAA
CAGC
CCCGGTGCCATCGAGCTGCGTACCTGCTGCTCCCCTCGCCTAAGGCTGCTGCAGATGGAC
CTGACC
AAACCAGGAGACATTAGCCGCTTGCTAGAGTTCACCAAGGCCCACACCACCAG
CACCGGCCTGTGGGGCC
TCGTCAACAACGCAGGCCACAATGAAGTAGTTGCTGATGCGG
AGCTGTCTCCAGTGGCCACTTTCCGTAG
CTGCATGGAGGTGAATTTCTTTGGCGCGCTC
GAGCTGACCAAGGGCCTCCTGCCCCTGCTGCGCAGCTCA
AGGGGCCGCATCGTGACTGT
GGGGAGCCCAGCGGGGGACATGCCATATCCGTGCTTGGGGGCCTATGGAA
CCTCCAAAG
CGGCCGTGGCGCTACTCATGGACACATTCAGCTGTGAACTCCTTCCCTGGGGGGTCAAGG
T
CAGCATCATCCAGCCTGGCTGCTTCAAGACAGAGTCAGTGAGAAACGTGGGTCAGTGG
GAAAAGCGCAAG
CAATTGCTGCTGGCCAACCTGCCTCAAGAGCTGCTGCAGGCCTACGG
CAAGGACTACATCGAGCACTTGC
ATGGGCAGTTCCTGCACTCGCTACGCCTGGCCATGT
CCGACCTCACCCCAGTTGTAGATGCCATCACAGA
TGCGCTGCTGGCAGCTCGGCCCCGC
CGCCGCTATTACCCCGGCCAGGGCCTGGGGCTCATGTACTTCATC
CACTACTACCTGCC
TGAAGGCCTGCGGCGCCGCTTCCTGCAGGCCTTCTTCATCAGTCACTGTCTGCCTC
GAG
CACTGCAGCCTGGCCAGCCTGGCACTACCCCACCACAGGACGCAGCCCAGGACCCAAACC
TGAGCCC
CGGCCCTTCCCCAGCAGTGGCTCGGTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
U14631

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_8_Locus:
16q22

# Metabolic_Enzyme_8_SNPs:
rs5479; rs5480; rs9923709; rs13329942; rs17855911; rs28934592; rs28934594; rs13306425; rs17853703; rs28934591; rs28934593; rs1139495; rs2855410; rs5481; rs2549646; rs35257037; rs2855408; rs12935213; rs12919979; rs12934342; rs12934368; rs2549644; rs12935253; rs12919584; rs12934351; rs28464206; rs12933947; rs34076422; rs2549647; rs11413878; rs2549645; rs12934369; rs13306424; rs2855411; rs2855407; rs2549643; rs2549641; rs2855406; rs2911119; rs2855405; rs2549642; rs2925933; rs28373713; rs12918538; rs2911120; rs1053099; rs1053271; rs11860837; rs1213164; rs12596882; rs16957430; rs1802795; rs2279023; rs34389524; rs4360931; rs6499129; rs8056260; rs9922476; rs9922624; rs9936153; rs9936306; rs9940901

# Metabolic_Enzyme_8_General_References:
7859916; 8530071; 8611140; 11350956; 2889032; 7608290; 7593417; 7670488; 9398712; 9683587; 9661590; 9851783; 9707624; 10489390; 10523339; 11238516

# Metabolic_Enzyme_8_References:
14670998; 15666848; 16616286

# Metabolic_Enzyme_9_ID:
8351

# Metabolic_Enzyme_9_Name:
Glucose-6-phosphatase

# Metabolic_Enzyme_9_Synonyms:
G6Pase; G-6-Pase

# Metabolic_Enzyme_9_Gene_Name:
G6PC

# Metabolic_Enzyme_9_Protein_Sequence:
>Glucose6phosphatase
MEEGMNVLHDFGIQSTHYLQVNYQDSQDWFILVSVIADLRNAFYVLFPIWFHLQEAVGIK
LLWVAVIGDWLNLVFKWILFGQRPYWWVLDTDYYSNTSVPLIKQFPVTCETGPGSPSGHA
MGTAGVYYVMVTSTLSIFQGKIKPTYRFRCLNVILWLGFWAVQLNVCLSRIYLAAHFPHQ
VVAGVLSGIAVTETFSHIHSIYNASLKKYFLITFFLFSFAIGFYLLLKGLGVDLLWTLEK
AQRWCEQPEWVHIDTTPFASLLKNLGTLFGLGLALNSSMYRESCKGKLSKWLPFRLSSIV
ASLVLLHVFDSLKPPSQVELVFYVLSFCKSAVVPLASVSVIPYCLAQVLGQPHKKSL

# Metabolic_Enzyme_9_Number_of_Residues:
357

# Metabolic_Enzyme_9_Molecular_Weight:
40514

# Metabolic_Enzyme_9_Theoretical_pI:
8.61

# Metabolic_Enzyme_9_GO_Classification:
Not Available

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
May be a single membrane channel protein acting both as a hydrolase and a translocase. It is the key enzyme in homeostatic regulation of blood glucose levels

# Metabolic_Enzyme_9_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_9_Reaction:
D-glucose 6-phosphate + H2O = D-glucose + phosphate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF01569:PAP2

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
30-46
59-75
153-169
211-227
296-312
320-336

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 3.1.3.9

# Metabolic_Enzyme_9_GenBank_ID_Protein:
452444

# Metabolic_Enzyme_9_SwissProt_ID:
G6PT_HUMAN (P35575)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
G6PC

# Metabolic_Enzyme_9_Geneatlas_id:
G6PC

# Metabolic_Enzyme_9_hgnc_id:
HGNC:4056

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein

# Metabolic_Enzyme_9_Gene_Sequence:
>1074 bp
ATGGAGGAAGGAATGAATGTTCTCCATGACTTTGGGATCCAGTCAACACATTACCTCCAG
GTGAATTACCAAGACTCCCAGGACTGGTTCATCTTGGTGTCCGTGATCGCAGACCTCAGG
AATGCCTTCTACGTCCTCTTCCCCATCTGGTTCCATCTTCAGGAAGCTGTGGGCATTAAA
CTCCTTTGGGTAGCTGTGATTGGAGACTGGCTCAACCTCGTCTTTAAGTGGATTCTCTTT
GGACAGCGTCCATACTGGTGGGTTTTGGATACTGACTACTACAGCAACACTTCCGTGCCC
CTGATAAAGCAGTTCCCTGTAACCTGTGAGACTGGACCAGGGAGCCCCTCTGGCCATGCC
ATGGGCACAGCAGGTGTATACTACGTGATGGTCACATCTACTCTTTCCATCTTTCAGGGA
AAGATAAAGCCGACCTACAGATTTCGGTGCTTGAATGTCATTTTGTGGTTGGGATTCTGG
GCTGTGCAGCTGAATGTCTGTCTGTCACGAATCTACCTTGCTGCTCATTTTCCTCATCAA
GTTGTTGCTGGAGTCCTGTCAGGCATTGCTGTTACAGAAACTTTCAGCCACATCCACAGC
ATCTATAATGCCAGCCTCAAGAAATATTTTCTCATTACCTTCTTCCTGTTCAGCTTCGCC
ATCGGATTTTATCTGCTGCTCAAGGGACTGGGTGTAGACCTCCTGTGGACTCTGGAGAAA
GCCCAGAGGTGGTGCGAGCAGCCAGAATGGGTCCACATTGACACCACACCCTTTGCCAGC
CTCCTCAAGAACCTGGGCACGCTCTTTGGCCTGGGGCTGGCTCTCAACTCCAGCATGTAC
AGGGAGAGCTGCAAGGGGAAACTCAGCAAGTGGCTCCCATTCCGCCTCAGCTCTATTGTA
GCCTCCCTCGTCCTCCTGCACGTCTTTGACTCCTTGAAACCCCCATCCCAAGTCGAGCTG
GTCTTCTACGTCTTGTCCTTCTGCAAGAGTGCGGTAGTGCCCCTGGCATCCGTCAGTGTC
ATCCCCTACTGCCTCGCCCAGGTCCTGGGCCAGCCGCACAAGAAGTCGTTGTAA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
U01120

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_9_Locus:
17q21

# Metabolic_Enzyme_9_SNPs:
rs161628; rs2229611; rs161620; rs161626; rs2593595; rs161621; rs161630; rs161634; rs161633; rs161631; rs161622; rs692466; rs161625; rs161632; rs555314; rs7213700; rs9899535; rs161627; rs9902963; rs692180; rs1801176; rs1801175; rs9905900; rs7210335; rs34960677; rs34959065; rs36092308; rs11436510; rs34537381; rs447268; rs692076; rs571000; rs2667937; rs7225801; rs35482744; rs12936784; rs35983714; rs2667938; rs34791838; rs673895; rs161629; rs161623; rs161624; rs28583935; rs570217; rs12450501; rs36031531; rs12103792; rs525189; rs36047740; rs11652764; rs2667935; rs4793182; rs35905772; rs11649970; rs1185293; rs12603239; rs172830; rs2593596; rs323495; rs324079; rs324080; rs324082; rs571330; rs691547; rs692198; rs7209982; rs7215072; rs8079497

# Metabolic_Enzyme_9_General_References:
8211187; 9705299; 7573034; 7623438; 7655466; 9001800; 8733042; 10094563; 10447271; 10612834

# Metabolic_Enzyme_9_References:
15081573; 16410665

# Macromolecular_Interacting_Partner_1_ID:
7197

# Macromolecular_Interacting_Partner_1_Name:
Corticotropin-lipotropin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Pro-opiomelanocortin; POMC[Contains: NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin]

# Macromolecular_Interacting_Partner_1_Gene_Name:
POMC

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Corticotropinlipotropin precursor
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
267

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
29424

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Beta-endorphin and Met-enkephalin are endogenous opiates

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00976:ACTH_domain;
PF08384:NPP;
PF08035:Op_neuropeptide

# Macromolecular_Interacting_Partner_1_Signals:
1-26

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
190188

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
COLI_HUMAN (P01189)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
POMC

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
POMC

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9201

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>789 bp
TGCAGCCGCTCGGGGGCCCTGTTGCTGGCCTTGCTGCTTCAGGCCTCCATGGAAGTGCGT
GGCTGGTGCCTGGAGAGCAGCCAGTGTCAGGACCTCACCACGGAAAGCAACCTGCTGGAG
TGCATCCGGGCCTGCAAGCCCGACCTCTCGGCCGAGACTCCCATGTTCCCGGGAAATGGC
GACGAGCAGCCTCTGACCGAGAACCCCCGGAAGTACGTCATGGGCCACTTCCGCTGGGAC
CGATTCGGCCGCCGCAACAGCAGCAGCAGCGGCAGCAGCGGCGCAGGGCAGAAGCGCGAG
GACGTCTCAGCGGGCGAAGACTGCGGCCCGCTGCCTGAGGGCGGCCCCGAGCCCCGCAGC
GATGGTGCCAAGCCGGGCCCGCGCGAGGGCAAGCGCTCCTACTCCATGGAGCACTTCCGC
TGGGGCAAGCCGGTGGGCAAGAAGCGGCGCCCAGTGAAGGTGTACCCTAACGGCGCCGAG
GACGAGTCGGCCGAGGCCTTCCCCCTGGAGTTCAAGAGGGAGCTGACTGGCCAGCGACTC
CGGGAGGGAGATGGCCCCGACGGCCCTGCCGATGACGGCGCAGGGGCCCAGGCCGACCTG
GAGCACAGCCTGCTGGTGGCGGCCGAGAAGAAGGACGAGGGCCCCTACAGGATGGAGCAC
TTCCGCTGGGGCAGCCCGCCCAAGGACAAGCGCTACGGCGGTTTCATGACCTCCGAGAAG
AGCCAGACGCCCCTGGTGACGCTGTTCAAAAACGCCATCATCAAGAACGCCTACAAGAAG
GGCGAGTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M38297

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_1_Locus:
2p23.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs28932472; rs8192606; rs28932471; rs35254395; rs8192605; rs28930368; rs2071345; rs34650613; rs1042571; rs11679531; rs6713532; rs7565877; rs6713396; rs12473543; rs6756695; rs6545975; rs6756566; rs28932474; rs28932476; rs28932475; rs28932473; rs10654394; rs28932470; rs3039380; rs35411223; rs35023083; rs33950052; rs7591899; rs15461; rs2071344; rs13388660; rs9973478; rs11353932; rs13404336; rs7565427; rs34619618; rs8192607; rs35639116; rs34526166; rs10188864; rs10195561; rs11892647; rs12472851; rs13418937; rs17046887; rs17046891; rs1866146; rs2071343; rs2118404; rs2164808; rs3769671; rs3795955; rs3820935; rs6545976; rs6719226; rs6734859; rs7589318; rs7605927; rs934778

# Macromolecular_Interacting_Partner_1_General_References:
6274691; 6299668; 6314261; 3606677; 6254047; 6945581; 6267033; 6272808; 4352834; 4334191; 4338630; 4347148; 1264228; 195688; 2424570; 2839146; 7828531; 9768693; 10193875; 11244459

# Macromolecular_Interacting_Partner_1_References:
12364444; 12508908; 12602534; 12643218

# Macromolecular_Interacting_Partner_2_ID:
7547

# Macromolecular_Interacting_Partner_2_Name:
Somatotropin precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Growth hormone; GH; GH-N; Pituitary growth hormone; Growth hormone 1

# Macromolecular_Interacting_Partner_2_Gene_Name:
GH1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Somatotropin precursor
MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEA
YIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLR
SVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDD
ALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
217

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
24848

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.09

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_2_Signals:
1-26

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
31905

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
SOMA_HUMAN (P01241)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
GH1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
GH1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:4261

# Macromolecular_Interacting_Partner_2_PDB_ID:
1HWG

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>654 bp
ATGGCTACAGGCTCCCGGACGTCCCTGCTCCTGGCTTTTGGCCTGCTCTGCCTGCCCTGG
CTTCAAGAGGGCAGTGCCTTCCCAACCATTCCCTTATCCAGGCCTTTTGACAACGCTATG
CTCCGCGCCCATCGTCTGCACCAGCTGGCCTTTGACACCTACCAGGAGTTTGAAGAAGCC
TATATCCCAAAGGAACAGAAGTATTCATTCCTGCAGAACCCCCAGACCTCCCTCTGTTTC
TCAGAGTCTATTCCGACACCCTCCAACAGGGAGGAAACACAACAGAAATCCAACCTAGAG
CTGCTCCGCATCTCCCTGCTGCTCATCCAGTCGTGGCTGGAGCCCGTGCAGTTCCTCAGG
AGTGTCTTCGCCAACAGCCTGGTGTACGGCGCCTCTGACAGCAACGTCTATGACCTCCTA
AAGGACCTAGAGGAAGGCATCCAAACGCTGATGGGGAGGCTGGAAGATGGCAGCCCCCGG
ACTGGGCAGATCTTCAAGCAGACCTACAGCAAGTTCGACACAAACTCACACAACGATGAC
GCACTACTCAAGAACTACGGGCTGCTCTACTGCTTCAGGAAGGACATGGACAAGGTCGAG
ACATTCCTGCGCATCGTGCAGTGCCGCTCTGTGGAGGGCAGCTGTGGCTTCTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00519

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_2_Locus:
17q24.2

# Macromolecular_Interacting_Partner_2_SNPs:
rs2001345; rs5388; rs6175; rs6173; rs6172; rs2665802; rs3744287; rs2001344; rs3020619; rs2005172; rs695; rs2854224; rs2854184; rs11568828; rs2011732; rs1974435; rs1811081; rs6171; rs2005171; rs2005170; rs7219235; rs2727338; rs6174; rs4080075; rs4080076; rs41295255; rs41295253; rs4080078; rs41295041; rs41295043; rs9282699; rs41295039; rs41295033; rs5821407; rs5821408; rs41295029; rs3833113; rs41295249; rs41295245; rs5821409; rs9282698; rs41295251; rs41295035; rs41295037; rs41295031; rs41295247; rs4341800; rs41299067; rs6146116; rs28485730; rs41295013; rs11568827; rs41295009; rs41295017; rs3760240; rs12945660; rs41295015; rs41299065; rs11079515; rs11657170; rs12946669; rs2070680; rs2532114; rs2532115; rs2665846; rs3180510; rs7209608

# Macromolecular_Interacting_Partner_2_General_References:
386281; 377496; 6269091; 7169009; 2744760; 10931946; 3912261; 5810834; 5144027; 4675454; 5279046; 5279528; 7462247; 7356479; 7028740; 10393484; 3447173; 1549776; 7984244; 8943276; 8552145; 9276733; 10391209; 11502836; 12655557

# Macromolecular_Interacting_Partner_2_References:
12401940; 14695985; 16926252; 17054472

# Macromolecular_Interacting_Partner_3_ID:
7549

# Macromolecular_Interacting_Partner_3_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
INS

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_3_Signals:
1-24

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
INS

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11p15.5

# Macromolecular_Interacting_Partner_3_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_3_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_3_References:
12505096; 12634448; 12809174; 12828082

# Macromolecular_Interacting_Partner_4_ID:
7551

# Macromolecular_Interacting_Partner_4_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_4_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_4_Locus:
6p21.3

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_4_References:
12429044; 14501948; 15194576; 15240630

# Macromolecular_Interacting_Partner_5_ID:
7556

# Macromolecular_Interacting_Partner_5_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_5_Signals:
1-18

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_5_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_5_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_5_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_5_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_5_References:
15562203

# Macromolecular_Interacting_Partner_6_ID:
7559

# Macromolecular_Interacting_Partner_6_Name:
Estrogen receptor

# Macromolecular_Interacting_Partner_6_Synonyms:
ER; Estradiol receptor; ER-alpha

# Macromolecular_Interacting_Partner_6_Gene_Name:
ESR1

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Estrogen receptor
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
595

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
66217

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
8.14

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  steroid binding
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF02159:Oest_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
31620888

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
ESR1_HUMAN (P03372)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
ESR1

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
ESR1

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:3467

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>63 bp
ATGCGCTGCGTCGCCTCTAACCTCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTC
TGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
X03635

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_6_Locus:
6q25.1

# Macromolecular_Interacting_Partner_6_SNPs:
Not Available

# Macromolecular_Interacting_Partner_6_General_References:
3753802; 3754034; 8600466; 14574404; 10619354; 7916651; 7476978; 7539106; 1577818; 7838153; 9627117; 10428798; 10567404; 10359819; 11113208; 11971969; 12415108; 2247153; 8221895; 9338790; 9600906; 9875847; 9619507; 2792078; 8961262; 9195227

# Macromolecular_Interacting_Partner_6_References:
12505096; 15013690; 15994348; 16297209

# Macromolecular_Interacting_Partner_7_ID:
6878

# Macromolecular_Interacting_Partner_7_Name:
Catalase

# Macromolecular_Interacting_Partner_7_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Name:
CAT

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Catalase
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT
KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD
THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE
HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK
NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
527

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
59757

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
7.41

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  catalase activity
 ||
>>>
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_7_Specific_Function:
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide

# Macromolecular_Interacting_Partner_7_Pathway:
map00380  Tryptophan metabolism;
 map00680  Methane metabolism

# Macromolecular_Interacting_Partner_7_Reaction:
2 H2O2 = O2 + 2 H2O

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00199:Catalase

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
EC 1.11.1.6

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
1228085

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
CATA_HUMAN (P04040)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
CAT

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
CAT

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:1516

# Macromolecular_Interacting_Partner_7_PDB_ID:
1F4J

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Peroxisome

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>66 bp
ATGGCTGACAGCCGGGATCCCGCCAGCGACCAGATGCAGCACTGGAAGGAGCAGCGGGCC
GCGCAG

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
X04085

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_7_Locus:
11p13

# Macromolecular_Interacting_Partner_7_SNPs:
rs17880442; rs11032709; rs769217; rs35677492; rs1049982; rs2234940; rs1050032; rs566979; rs769218; rs511895; rs524167; rs494024; rs1408035; rs560807; rs10488736; rs2284367; rs482322; rs7947841; rs480496; rs11032699; rs2300182; rs2284365; rs7103083; rs499406; rs3758730; rs4755372; rs508370; rs7933285; rs1000343; rs554576; rs2073059; rs11032701; rs17886008; rs4755373; rs484214; rs6484722; rs543701; rs17884666; rs2420389; rs551929; rs480575; rs10836244; rs2179625; rs7113917; rs2268063; rs533425; rs12272630; rs17881488; rs486256; rs17884576; rs2073058; rs11604331; rs17884491; rs7120960; rs1408034; rs524154; rs7109778; rs7101395; rs17881288; rs12269988; rs7126610; rs10836235; rs16925608; rs16925614; rs11824384; rs2284368; rs17883121; rs2420388; rs4756146; rs16925606; rs17884086; rs2284364; rs7930427; rs12803540; rs1408036; rs17268652; rs2284366; rs17881567; rs2300181; rs7928213; rs11032702; rs16925581; rs525938; rs11032700; rs17881921; rs17884095; rs17885743; rs17881476; rs17883793; rs11826620; rs12270780; rs35915891; rs2268064; rs17883592; rs17884725; rs17881482; rs17880673; rs2284369; rs17883544; rs11032703; rs12273124; rs17884248; rs35755143; rs7126640; rs2076556; rs4755374; rs1055981; rs17884335; rs17884518; rs17880274; rs17883699; rs4756148; rs17886200; rs475043; rs564250; rs769214; rs9282626; rs7943316; rs9282627; rs7104301; rs17883920; rs1001179; rs17881029; rs17886350; rs2266625; rs34455645; rs3180560; rs11546300; rs1050028; rs2266629; rs2266619; rs14527; rs2266628; rs35012776; rs34964953; rs34727149; rs3831770; rs17886810; rs35927227; rs7121850; rs17885881; rs17882812; rs17885837; rs17880607; rs17882039; rs17881916; rs17880549; rs34138762; rs28586982; rs34503767; rs36074933; rs515130; rs35099202; rs35849009; rs17881846; rs17887048; rs17881224; rs17884421; rs34840731; rs17881231; rs35340649; rs35292563; rs17884242; rs12286702; rs35034960; rs28733253; rs17887248; rs35791482; rs35703808; rs35648206; rs34808995; rs35386961; rs34420404; rs856714; rs17883483; rs17884804; rs17883367; rs17883534; rs17880160; rs17886672; rs34281397; rs34790990; rs2982523; rs35122257; rs2284370; rs12798927; rs35781217; rs11032707; rs17886592; rs4483566; rs34890123; rs4272763; rs12789374; rs17881734; rs35330036; rs17883434; rs35081167; rs17886155; rs17886248; rs34840787; rs34890990; rs17881192; rs17881586; rs34267165; rs12786539; rs35834969; rs3818354; rs17884443; rs36224415; rs36224416; rs36224102; rs10312; rs10836230; rs10836233; rs10836234; rs11032717; rs1107573; rs11606946; rs12284341; rs12807961; rs12808450; rs1323690; rs1535718; rs1535719; rs1535720; rs1535721; rs16925525; rs2073057; rs208678; rs208679; rs208681; rs208682; rs208683; rs2231828; rs2266624; rs2266630; rs2296144; rs409598; rs554518; rs7109862; rs7114869; rs7118388; rs7928156; rs7941147; rs7944397; rs7949972

# Macromolecular_Interacting_Partner_7_General_References:
3755525; 3755526; 11728823; 8282800; 12665801; 6548744; 10666617; 10656833; 11134921

# Macromolecular_Interacting_Partner_7_References:
12475388; 12724945; 16809378

# Macromolecular_Interacting_Partner_8_ID:
6946

# Macromolecular_Interacting_Partner_8_Name:
Sex hormone-binding globulin precursor

# Macromolecular_Interacting_Partner_8_Synonyms:
SHBG; Sex steroid-binding protein; SBP; Testis-specific androgen-binding protein; ABP; Testosterone-estrogen-binding globulin; Testosterone-estradiol- binding globulin; TeBG

# Macromolecular_Interacting_Partner_8_Gene_Name:
SHBG

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Sex hormonebinding globulin precursor
MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMT
FDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGA
GPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPAS
NLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDI
PQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPL
VLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTS
FCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
402

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
43780

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
6.70

# Macromolecular_Interacting_Partner_8_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00054:Laminin_G_1

# Macromolecular_Interacting_Partner_8_Signals:
1-29

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
296673

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
SHBG_HUMAN (P04278)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
SHBG

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
SHBG

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:10839

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Secreted protein. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis (By similarity)

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1209 bp
ATGGAGAGCAGAGGCCCACTGGCTACCTCGCGCCTGCTGCTGTTGCTGCTGTTGCTACTA
CTGCGTCACACCCGCCAGGGATGGGCCCTGAGACCTGTTCTCCCCACCCAGAGTGCCCAC
GACCCTCCGGCTGTCCACCTCAGCAATGGCCCAGGACAAGAGCCTATCGCTGTCATGACC
TTTGACCTCACCAAGATCACAAAAACCTCCTCCTCCTTTGAGGTTCGAACCTGGGACCCA
GAGGGAGTGATTTTTTATGGGGATACCAACCCTAAGGATGACTGGTTTATGCTGGGACTT
CGAGACGGCAGGCCTGAGATCCAACTGCACAATCACTGGGCCCAGCTTACGGTGGGTGCT
GGACCACGGCTGGATGATGGGAGATGGCACCAGGTGGAAGTCAAGATGGAGGGGGACTCT
GTGCTGCTGGAGGTGGATGGGGAGGAGGTGCTGCGCCTGAGACAGGTCTCTGGGCCCCTG
ACCAGCAAACGCCATCCCATCATGAGGATTGCGCTTGGGGGGCTGCTCTTCCCCGCTTCC
AACCTTCGGTTGCCGCTGGTTCCTGCCCTGGATGGCTGCCTGCGCCGGGATTCCTGGCTG
GACAAACAGGCCGAGATCTCAGCATCTGCCCCCACTAGCCTCAGAAGCTGTGATGTAGAA
TCAAATCCCGGGATATTTCTCCCTCCAGGGACTCAGGCAGAATTCAATCTCCGAGACATT
CCCCAGCCTCATGCAGAGCCCTGGGCCTTCTCTTTGGACCTGGGACTCAAGCAGGCAGCA
GGCTCAGGCCACCTCCTTGCTCTTGGGACACCAGAGAACCCATCTTGGCTCAGTCTCCAC
CTCCAAGATCAAAAGGTGGTGTTGTCTTCTGGGTCGGGGCCAGGGCTGGATCTGCCCCTG
GTCTTGGGACTCCCTCTTCAGCTGAAGCTGAGTATGTCCAGGGTGGTCTTGAGCCAAGGG
TCGAAGATGAAGGCCCTTGCCCTGCCTCCCTTAGGCCTGGCTCCCCTCCTTAACCTCTGG
GCCAAGCCTCAAGGGCGTCTCTTCCTGGGGGCTTTACCAGGAGAAGACTCTTCCACCTCT
TTTTGCCTGAATGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAAC
AGAAGCCATGAGATCTGGACTCACAGCTGCCCCCAGAGCCCAGGCAATGGCACTGACGCT
TCCCATTAA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
X16349

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_8_Locus:
17p13-p12

# Macromolecular_Interacting_Partner_8_SNPs:
rs6260; rs6258; rs9282845; rs6259; rs6261; rs4987212; rs9282846; rs6257; rs9913778; rs858517; rs1799941; rs858516; rs35167070; rs34865989; rs34420533; rs35338190; rs3760213; rs8065089; rs5030659; rs13894; rs1641536; rs1641537; rs1641544; rs1642800; rs2543553; rs2955617; rs34780532; rs727428; rs858520; rs858521; rs9898876

# Macromolecular_Interacting_Partner_8_General_References:
2587256; 2608061; 3569533; 2956126; 2956125; 3702459; 3542030; 1400872; 10675319; 12065592; 7714097; 10391209

# Macromolecular_Interacting_Partner_8_References:
12640346; 12672036; 12688162; 12756844

# Macromolecular_Interacting_Partner_9_ID:
6332

# Macromolecular_Interacting_Partner_9_Name:
Cytochrome P450 17A1

# Macromolecular_Interacting_Partner_9_Synonyms:
CYPXVII; P450-C17; P450c17; Steroid 17-alpha-monooxygenase; Steroid 17-alpha-hydroxylase/17,20 lyase

# Macromolecular_Interacting_Partner_9_Gene_Name:
CYP17A1

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Cytochrome P450 17A1
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGT
KTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGA
HWQLHRRLAMATFALFKDGDQ
KLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNV
ISLICFNTSYKNGDPELNVIQNYNEGIIDNLS
KDSLVDLVPWLKIFPNKTLEKLKSHVK
IRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGP
DQDSELLSDNHILTTI
GDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRL
LLLEA
TIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPE
RFLNP
AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLP
SLEGIPKVVFLIDSFK
VKIKVRQAWREAQAEGST

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
508

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
57371

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
8.87

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_9_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Macromolecular_Interacting_Partner_9_Specific_Function:
Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty

# Macromolecular_Interacting_Partner_9_Pathway:
map00140  C21-Steroid hormone metabolism

# Macromolecular_Interacting_Partner_9_Reaction:
a steroid + AH2 + O2 = a 17alpha-hydroxysteroid + A + H2O

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00067:p450

# Macromolecular_Interacting_Partner_9_Signals:
1-24

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
EC 1.14.99.9

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
181342

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
CP17A_HUMAN (P05093)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
CYP17A1

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
CYP17A1

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:2593

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>1527 bp

ATGTGGGAGCTCGTGGCTCTCTTGCTGCTTACCCTAGCTTATTTGTTTTGGCCCAAGAG
AAGGTGCCCTG
GTGCCAAGTACCCCAAGAGCCTCCTGTCCCTGCCCCTGGTGGGCAGCC
TGCCATTCCTCCCCAGACATGG
CCATATGCATAACAACTTCTTCAAGCTGCAGAAAAAA
TATGGCCCCATCTATTCTGTTCGTATGGGCACC
AAGACTACAGTGATTGTCGGCCACCA
CCAGCTGGCCAAGGAGGTGCTTATTAAGAAGGGCAAGGACTTCT
CTGGGCGGCCTCAAA
TGGCAACTCTAGACATCGCGTCCAACAACCGTAAGGGTATCGCCTTCGCTGACTC
TGGC
GCACACTGGCAGCTGCATCGAAGGCTGGCGATGGCCACCTTTGCCCTGTTCAAGGATGGC
GATCAG
AAGCTGGAGAAGATCATTTGTCAGGAAATCAGTACATTGTGTGATATGCTGGC
CACCCACAACGGACAGT
CCATAGACATCTCCTTTCCTGTCTTCGTGGCGGTAACCAATG
TCATCTCCTTGATCTGCTTCAATACCTC
CTACAAGAATGGGGACCCTGAGTTGAATGTC
ATACAGAATTACAATGAAGGCATCATAGACAACCTGAGC
AAAGACAGCCTGGTGGACCT
AGTCCCCTGGTTGAAGATTTTCCCCAACAAAACCCTGGAAAAATTAAAGA
GCCATGTTA
AAATACGAAATGATCTGCTGAATAAAATACTTGAAAATTACAAGGAGAAATTCCGGAGTG
A
CTCTATCACCAACATGCTGGACACACTGATGCAAGCCAAGATGAACTCAGATAATGGC
AATGCTGGCCCA
GATCAAGATTCAGAGCTGCTTTCAGATAACCACATTCTCACCACCAT
AGGGGACATCTTTGGGGCTGGCG
TGGAGACCACCACCTCTGTGGTTAAATGGACCCTGG
CCTTCCTGCTGCACAATCCTCAGGTGAAGAAGAA
GCTCTACGAGGAGATTGACCAGAAT
GTGGGTTTCAGCCGCACACCAACTATCAGTGACCGTAACCGTCTC
CTCCTGCTGGAGGC
CACCATCCGAGAGGTGCTTCGCCTCAGGCCCGTGGCCCCTATGCTCATCCCCCACA
AGG
CCAACGTTGACTCCAGCATCGGTGAGTTTGCTGTGGACAAGGGCACAGAAGTTATCATCA
ATCTGTG
GGCGCTGCATCACAATGAGAAGGAGTGGCACCAGCCGGATCAGTTCATGCCT
GAGCGTTTCTTGAATCCA
GCGGGGACCCAGCTCATCTCACCGTCAGTAAGCTATTTGCC
CTTCGGAGCAGGACCTCGCTCCTGTATAG
GTGAGATCCTGGCCCGCCAGGAGCTCTTCC
TCATCATGGCCTGGCTGCTGCAGAGGTTCGACCTGGAGGT
GCCAGATGATGGGCAGCTG
CCCTCCCTGGAAGGCATCCCCAAGGTGGTCTTTCTGATCGACTCTTTCAAA
GTGAAGAT
CAAGGTGCGCCAGGCCTGGAGGGAAGCCCAGGCTGAGGGTAGCACCTAA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
M14564

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_9_Locus:
10q24.3

# Macromolecular_Interacting_Partner_9_SNPs:
rs762563; rs6163; rs6162; rs1042386; rs6164; rs743572; rs10883783; rs4919687; rs3781286; rs10786712; rs3781287; rs743575; rs1004467; rs4919686; rs17115100; rs3824755; rs284847; rs755443; rs17115104; rs3740397; rs284849; rs3020724; rs12254149; rs17855149; rs3211406; rs17115125; rs3020717; rs34343941; rs3020712; rs34132012; rs3020723; rs35403742; rs3020714; rs3020715; rs34431726; rs284848; rs3020719; rs3020721; rs284850; rs34983874; rs35538238; rs35144627; rs34713150; rs35165247; rs2911432; rs7922856; rs12219555; rs35745115; rs3020718; rs35115800; rs34846786; rs2911431; rs11191413; rs3020711; rs3020720; rs34485280; rs34620611; rs3020713; rs3020722; rs11191412; rs3890077; rs11191411; rs12775422; rs11191410; rs34005085; rs10509762; rs10883782; rs11191406; rs11191416; rs12242445; rs17115144; rs17115149; rs2486758; rs4919682; rs4919683; rs4919685; rs619824; rs7082755; rs7089422

# Macromolecular_Interacting_Partner_9_General_References:
3025870; 3500022; 3274893; 1964490; 2843762; 10406467; 2808364; 1714904; 1515452; 1740503; 8396144; 8245018; 8345056; 8027220; 8550762; 10720067; 11549685; 11836339; 12466376

# Macromolecular_Interacting_Partner_9_References:
14504283; 15169901; 15514033; 15934942

# Macromolecular_Interacting_Partner_10_ID:
7569

# Macromolecular_Interacting_Partner_10_Name:
Interleukin-6 precursor

# Macromolecular_Interacting_Partner_10_Synonyms:
IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF

# Macromolecular_Interacting_Partner_10_Gene_Name:
IL6

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Interleukin6 precursor
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYI
LDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLL
EFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQ
AQNQWLQDMTTHLILRSFKEFLQSSLRALRQM

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
212

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
23718

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
6.52

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interleukin-6 receptor binding
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
IL-6 is a cytokine with a wide variety of biological functions:it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00489:IL6

# Macromolecular_Interacting_Partner_10_Signals:
1-29

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
32674

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
IL6_HUMAN (P05231)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
IL6

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
IL6

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:6018

# Macromolecular_Interacting_Partner_10_PDB_ID:
2IL6

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>639 bp
ATGAACTCCTTCTCCACAAGCGCCTTCGGTCCAGTTGCCTTCTCCCTGGGGCTGCTCCTG
GTGTTGCCTGCTGCCTTCCCTGCCCCAGTACCCCCAGGAGAAGATTCCAAAGATGTAGCC
GCCCCACACAGACAGCCACTCACCTCTTCAGAACGAATTGACAAACAAATTCGGTACATC
CTCGACGGCATCTCAGCCCTGAGAAAGGAGACATGTAACAAGAGTAACATGTGTGAAAGC
AGCAAAGAGGCACTGGCAGAAAACAACCTGAACCTTCCAAAGATGGCTGAAAAAGATGGA
TGCTTCCAATCTGGATTCAATGAGGAGACTTGCCTGGTGAAAATCATCACTGGTCTTTTG
GAGTTTGAGGTATACCTAGAGTACCTCCAGAACAGATTTGAGAGTAGTGAGGAACAAGCC
AGAGCTGTCCAGATGAGTACAAAAGTCCTGATCCAGTTCCTGCAGAAAAAGGCAAAGAAT
CTAGATGCAATAACCACCCCTGACCCAACCACAAATGCCAGCCTGCTGACGAAGCTGCAG
GCACAGAACCAGTGGCTGCAGGACATGACAACTCATCTCATTCTGCGCAGCTTTAAGGAG
TTCCTGCAGTCCAGCCTGAGGGCTCTTCGGCAAATGTAG

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
X04430

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_10_Locus:
7p21

# Macromolecular_Interacting_Partner_10_SNPs:
rs2069860; rs13306435; rs2069830; rs2069849; rs2069850; rs2069851; rs13306436; rs2069857; rs3087226; rs1474347; rs2069833; rs2069832; rs1554606; rs2069842; rs1548216; rs2069840; rs2066992; rs1474348; rs2069835; rs2069831; rs2069845; rs2069838; rs2069834; rs2069837; rs1524107; rs2069841; rs3087232; rs13306433; rs34277345; rs2069847; rs3087227; rs2069848; rs35361244; rs34249410; rs3087228; rs3087233; rs3087230; rs2069843; rs3087229; rs2069844; rs3087231; rs2069858; rs1800795; rs2069824; rs1800797; rs7802308; rs1800796; rs7802307; rs2069829; rs3087223; rs2069827; rs2069825; rs3087225; rs2069861; rs36215814; rs2234683; rs2069828; rs11544633; rs41477054; rs13306438; rs3915892; rs3915893; rs2069839; rs13306434; rs3087234; rs2069846; rs2069836; rs3087235; rs2069859; rs13447445; rs36215459; rs36215820; rs35081782; rs35178191; rs13447446; rs2069826; rs34328912; rs3087224; rs36215821; rs4335044; rs36215822; rs11973115; rs36215817; rs11445458; rs34224237; rs36215461; rs36215818; rs34280821; rs34012176; rs34709428; rs10242595; rs10499563; rs11766273; rs12700386; rs12700390; rs13438415; rs1546762; rs1546763; rs17147230; rs1880241; rs1880242; rs1880243; rs2069852; rs2069853; rs2069854; rs2069855; rs2069862; rs3087221; rs3087238; rs35610689; rs4398801; rs4719713; rs4719714; rs6461662; rs6946908; rs6963444; rs6963591; rs7458109; rs7784987; rs7801617; rs7805828; rs940367

# Macromolecular_Interacting_Partner_10_General_References:
3491322; 3500852; 3538015; 3023045; 3320204; 2789513; 3758081; 3266463; 1291290; 3279116; 2610854; 1883960; 7851440; 2472117; 2037043; 8555185; 9159484; 9118960

# Macromolecular_Interacting_Partner_10_References:
12429044; 12562454; 14501948; 15647427

# Macromolecular_Interacting_Partner_11_ID:
6947

# Macromolecular_Interacting_Partner_11_Name:
Androgen receptor

# Macromolecular_Interacting_Partner_11_Synonyms:
Dihydrotestosterone receptor

# Macromolecular_Interacting_Partner_11_Gene_Name:
AR

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Androgen receptor
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQ
QQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSA
LECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLK
DILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELCKA
VSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAGKS
TEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQSR
DYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGP
GSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPY
GYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLE
TARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRND
CTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKLT
VSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRM
YSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDR
IIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIIS
VQVPKILSGKVKPIYFHTQ

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
919

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
98990

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
6.38

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  transcription factor activity
Function:  steroid binding
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  androgen receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_11_General_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Specific_Function:
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Activated, but not phosphorylated, by HIPK3

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF02166:Androgen_recep;
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_11_Signals:
None

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
178628

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
ANDR_HUMAN (P10275)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
AR

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
AR

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:644

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>2760 bp
ATGGAAGTGCAGTTAGGGCTGGGAAGGGTCTACCCTCGGCCGCCGTCCAAGACCTACCGA
GGAGCTTTCCAGAATCTGTTCCAGAGCGTGCGCGAAGTGATCCAGAACCCGGGCCCCAGG
CACCCAGAGGCCGCGAGCGCAGCACCTCCCGGCGCCAGTTTGCTGCTGCTGCAGCAGCAG
CAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAAGAGACT
AGCCCCAGGCAGCAGCAGCAGCAGCAGGGTGAGGATGGTTCTCCCCAAGCCCATCGTAGA
GGCCCCACAGGCTACCTGGTCCTGGATGAGGAACAGCAACCTTCACAGCCGCAGTCGGCC
CTGGAGTGCCACCCCGAGAGAGGTTGCGTCCCAGAGCCTGGAGCCGCCGTGGCCGCCAGC
AAGGGGCTGCCGCAGCAGCTGCCAGCACCTCCGGACGAGGATGACTCAGCTGCCCCATCC
ACGTTGTCCCTGCTGGGCCCCACTTTCCCCGGCTTAAGCAGCTGCTCCGCTGACCTTAAA
GACATCCTGAGCGAGGCCAGCACCATGCAACTCCTTCAGCAACAGCAGCAGGAAGCAGTA
TCCGAAGGCAGCAGCAGCGGGAGAGCGAGGGAGGCCTCGGGGGCTCCCACTTCCTCCAAG
GACAATTACTTAGGGGGCACTTCGACCATTTCTGACAACGCCAAGGAGTTGTGTAAGGCA
GTGTCGGTGTCCATGGGCCTGGGTGTGGAGGCGTTGGAGCATCTGAGTCCAGGGGAACAG
CTTCGGGGGGATTGCATGTACGCCCCACTTTTGGGAGTTCCACCCGCTGTGCGTCCCACT
CCTTGTGCCCCATTGGCCGAATGCAAAGGTTCTCTGCTAGACGACAGCGCAGGCAAGAGC
ACTGAAGATACTGCTGAGTATTCCCCTTTCAAGGGAGGTTACACCAAAGGGCTAGAAGGC
GAGAGCCTAGGCTGCTCTGGCAGCGCTGCAGCAGGGAGCTCCGGGACACTTGAACTGCCG
TCTACCCTGTCTCTCTACAAGTCCGGAGCACTGGACGAGGCAGCTGCGTACCAGAGTCGC
GACTACTACAACTTTCCACTGGCTCTGGCCGGACCGCCGCCCCCTCCGCCGCCTCCCCAT
CCCCACGCTCGCATCAAGCTGGAGAACCCGCTGGACTACGGCAGCGCCTGGGCGGCTGCG
GCGGCGCAGTGCCGCTATGGGGACCTGGCGAGCCTGCATGGCGCGGGTGCAGCGGGACCC
GGTTCTGGGTCACCCTCAGCCGCCGCTTCCTCATCCTGGCACACTCTCTTCACAGCCGAA
GAAGGCCAGTTGTATGGACCGTGTGGTGGTGGTGGGGGTGGTGGCGGCGGCGGCGGCGGC
GGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGAGGCGGGAGCTGTAGCCCCCTAC
GGCTACACTCGGCCCCCTCAGGGGCTGGCGGGCCAGGAAAGCGACTTCACCGCACCTGAT
GTGTGGTACCCTGGCGGCATGGTGAGCAGAGTGCCCTATCCCAGTCCCACTTGTGTCAAA
AGCGAAATGGGCCCCTGGATGGATAGCTACTCCGGACCTTACGGGGACATGCGTTTGGAG
ACTGCCAGGGACCATGTTTTGCCCATTGACTATTACTTTCCACCCCAGAAGACCTGCCTG
ATCTGTGGAGATGAAGCTTCTGGGTGTCACTATGGAGCTCTCACATGTGGAAGCTGCAAG
GTCTTCTTCAAAAGAGCCGCTGAAGGGAAACAGAAGTACCTGTGCGCCAGCAGAAATGAT
TGCACTATTGATAAATTCCGAAGGAAAAATTGTCCATCTTGTCGTCTTCGGAAATGTTAT
GAAGCAGGGATGACTCTGGGAGCCCGGAAGCTGAAGAAACTTGGTAATCTGAAACTACAG
GAGGAAGGAGAGGCTTCCAGCACCACCAGCCCCACTGAGGAGACAACCCAGAAGCTGACA
GTGTCACACATTGAAGGCTATGAATGTCAGCCCATCTTTCTGAATGTCCTGGAAGCCATT
GAGCCAGGTGTAGTGTGTGCTGGACACGACAACAACCAGCCCGACTCCTTTGCAGCCTTG
CTCTCTAGCCTCAATGAACTGGGAGAGAGACAGCTTGTACACGTGGTCAAGTGGGCCAAG
GCCTTGCCTGGCTTCCGCAACTTACACGTGGACGACCAGATGGCTGTCATTCAGTACTCC
TGGATGGGGCTCATGGTGTTTGCCATGGGCTGGCGATCCTTCACCAATGTCAACTCCAGG
ATGCTCTACTTCGCCCCTGATCTGGTTTTCAATGAGTACCGCATGCACAAGTCCCGGATG
TACAGCCAGTGTGTCCGAATGAGGCACCTCTCTCAAGAGTTTGGATGGCTCCAAATCACC
CCCCAGGAATTCCTGTGCATGAAAGCACTGCTACTCTTCAGCATTATTCCAGTGGATGGG
CTGAAAAATCAAAAATTCTTTGATGAACTTCGAATGAACTACATCAAGGAACTCGATCGT
ATCATTGCATGCAAAAGAAAAAATCCCACATCCTGCTCAAGACGCTTCTACCAGCTCACC
AAGCTCCTGGACTCCGTGCAGCCTATTGCGAGAGAGCTGCATCAGTTCACTTTTGACCTG
CTAATCAAGTCACACATGGTGAGCGTGGACTTTCCGGAAATGATGGCAGAGATCATCTCT
GTGCAAGTGCCCAAGATCCTTTCTGGGAAAGTCAAGCCCATCTATTTCCACACCCAGTGA


# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
M20132

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_11_Locus:
Xq11.2-q12

# Macromolecular_Interacting_Partner_11_SNPs:
rs9332970; rs9332971; rs9332968; rs6154; rs6153; rs6152; rs2767564; rs1926927; rs7065472; rs1337077; rs1337078; rs7064188; rs1337080; rs2255702; rs1204038; rs5918757; rs4827547; rs12007252; rs5918760; rs1204039; rs1337079; rs1926926; rs4827545; rs1572500; rs5919394; rs2361634; rs1572501; rs2207040; rs7061037; rs4827546; rs12014709; rs5919393; rs12011519; rs6624304; rs16989056; rs1361038; rs5919402; rs2361630; rs12009820; rs5918763; rs5031002; rs1337076; rs5965433; rs5918762; rs17217069; rs2361629; rs1204040; rs12010355; rs12009650; rs4827400; rs5919408; rs12862891; rs4618851; rs2885324; rs1926925; rs12009160; rs4261023; rs5918764; rs7053042; rs5919395; rs7053539; rs12007014; rs5919411; rs9282610; rs12011793; rs34899607; rs5919409; rs6625192; rs1337075; rs4993619; rs16989058; rs5919396; rs5919403; rs12396249; rs12011839; rs11795851; rs34135606; rs11797145; rs16990313; rs12011518; rs5918758; rs34070681; rs12014623; rs4393047; rs11798429; rs5919392; rs7474293; rs16990322; rs12007513; rs11497352; rs34769252; rs9332969; rs1800053; rs9332972; rs12394583; rs12558349; rs34279752; rs34542167; rs12850901; rs12835888; rs12353686; rs12855990; rs11300116; rs34908546; rs3070073; rs4281240; rs28753893; rs12856708; rs4451455; rs7061565; rs35645431; rs1577774; rs36064324; rs1361039; rs35122308; rs35099711; rs35535776; rs11461009; rs1577776; rs12833196; rs35625503; rs12846224; rs12836266; rs36110198; rs10706297; rs12834564; rs12836056; rs12849709; rs12848807; rs4827399; rs6624302; rs4500207; rs7054901; rs34043358; rs2885320; rs5016202; rs4540555; rs12833578; rs12013056; rs35809402; rs7060002; rs5918761; rs5919412; rs1577773; rs35044641; rs34070729; rs10856045; rs34434496; rs5919400; rs4489446; rs28402724; rs34642310; rs35624751; rs2361632; rs34878648; rs5965428; rs1204041; rs11380458; rs12864107; rs12837932; rs5965427; rs34951605; rs12393203; rs35953490; rs12835668; rs7055888; rs4459010; rs2878448; rs11094028; rs28580341; rs5919404; rs12832474; rs35888906; rs12864066; rs12847395; rs12395102; rs5919399; rs10622053; rs10553807; rs3070104; rs36168959; rs12840191; rs12837043; rs12848810; rs36099326; rs12009829; rs34077836; rs9699316; rs34754285; rs12851299; rs35747505; rs10564872; rs12835243; rs7052941; rs35098115; rs12859822; rs2878449; rs3795188; rs7062560; rs34742794; rs12851535; rs35630657; rs5964604; rs12849096; rs35546171; rs4497110; rs5965426; rs12401043; rs4827402; rs11799017; rs12843690; rs35819077; rs34792775; rs35617974; rs12838075; rs34664808; rs4292843; rs1577778; rs34997701; rs5918756; rs12857875; rs11428245; rs2361636; rs11424271; rs6653153; rs11367126; rs5919410; rs12843659; rs12835932; rs6625193; rs12851734; rs35316597; rs12851221; rs5016201; rs4413923; rs1577775; rs12836926; rs12856976; rs5919398; rs12851526; rs34418137; rs34604425; rs12689165; rs35377720; rs12863183; rs2361635; rs12857354; rs7065530; rs12835940; rs35020767; rs35774629; rs35847971; rs4827549; rs1577777; rs12857337; rs2223823; rs3795189; rs5919397; rs12837784; rs12836735; rs36063595; rs35442632; rs12833469; rs36075392; rs34317430; rs4446868; rs6625199; rs11316774; rs12862050; rs11094026; rs5965425; rs34851516; rs7474075; rs5965429; rs11351755; rs2070757; rs34566600; rs35506153; rs35025615; rs3032358; rs10060; rs17302090; rs1931537; rs2282289; rs2362520; rs5919413; rs5919414; rs7440

# Macromolecular_Interacting_Partner_11_General_References:
3216866; 2594783; 2342476; 3174628; 12361945; 2911578; 2293020; 2917688; 3353726; 3377788; 2546571; 3353727; 1775137; 1561105; 9096391; 10332029; 10400640; 10625666; 10930412; 12415108; 12612053; 10840043; 11906285; 1458719; 8339746; 8240973; 7937057; 7626493; 9016528; 2260966; 2082179; 1856263; 1999491; 2010552; 2062380; 1609793; 1424203; 1426313; 1487249; 1307250; 1569163; 1464650; 1430233; 1562539; 1316540; 1480178; 1303262; 1631125; 8213813; 8224266; 8103398; 8281139; 8281140; 8325932; 8325950; 8097257; 8096390; 8274409; 8446106; 8413310; 8145761; 7511268; 8292051; 8187068; 7910529; 7909256; 8205256; 8033918; 8162033; 7981687; 7981689; 8126121; 7962294; 8040309; 7929841; 7993455; 7970939; 8830623; 7712463; 7641413; 7671849; 7633398; 7537149; 7581399; 7591265; 7673412; 8530589; 7649358; 7723794; 8723113; 9816170; 9039340; 9001799; 8824883; 8550758; 8626869; 8768864; 8823308; 8918984; 8683794; 8647313; 8809734; 8628719; 8827083; 9106550; 9000575; 9196614; 9160185; 9007482; 8990010; 9438000; 9184448; 9255042; 9329414; 9252933; 9328206; 9302173; 9544375; 9698822; 9788719; 9610419; 9856504; 9554754; 9554755; 9543136; 9768671; 9851768; 9627582; 9607727; 10470409; 10363963; 10502786; 10571951; 10221692; 10404311; 10022458; 10629558; 10569618; 10543676; 10221770; 10598582; 10590024; 10458483; 10092153; 10706109; 10690872; 11587068; 11744994

# Macromolecular_Interacting_Partner_11_References:
14556282; 14612999; 14662261; 15249140

# Macromolecular_Interacting_Partner_12_ID:
7016

# Macromolecular_Interacting_Partner_12_Name:
Microtubule-associated protein 2

# Macromolecular_Interacting_Partner_12_Synonyms:
MAP 2; MAP-2

# Macromolecular_Interacting_Partner_12_Gene_Name:
MAP2

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Microtubuleassociated protein 2
MADERKDEGKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGE
HGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQT
AALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEK
ESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQK
TEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDD
IPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPA
TAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETV
QQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHT
FSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSSIQELFEMR
VDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRE
SVHESIDTMSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQERMF
TIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGR
GHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESKEEEQIEKVKATGEEST
QAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVV
EDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGT
DDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDRL
DTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLS
SVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTP
SSKAPQEADAFMGVESGHMKEGTKVSETEVKQKVAKPDLVHQEAVDKEESYESSGEHESL
TMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQGP
KEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDL
GVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVE
RRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDD
SIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRIST
PERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLS
CVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDE
NSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTP
SYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGST
DNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKVQAKV
GSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSS
GSINLLESPQLATLAEDVTAALAKQGL

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
1827

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
199540

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
4.55

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of cellular physiological process
Process:  regulation of cell organization and biogenesis
Process:  regulation of microtubule polymerization or depolymerization
Process:  negative regulation of microtubule polymerization or depolymerization
Process:  negative regulation of microtubule depolymerization
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_12_General_Function:
Cell motility 

# Macromolecular_Interacting_Partner_12_Specific_Function:
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF08377:MAP2_projctn;
PF00418:Tubulin-binding

# Macromolecular_Interacting_Partner_12_Signals:
None

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
409875

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
MAP2_HUMAN (P11137)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
MAP2

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
MAP2

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:6839

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>5481 bp
ATGGCAGATGAACGGAAAGACGAAGCAAAGGCACCTCACTGGACCTCAGCACCGCTAACA
GAGGCATCTGCACACTCACATCCACCTGAGATTAAGGATCAAGGCGGACGAGGGGAAGGA
CTTGTCCGAAGCGCCAATGGATTCCCATACAGGGAGGATGAAGAGGGTGCCTTTGGAGAG
CATGGGTCACAGGGCACCTATTCAAATACCAAAGAGAATGGGATCAACGGAGAGCTGACC
TCAGCTGACAGAGAAACAGCAGAGGAGGTGTCTGCAAGGATAGTTCAAGTAGTCACTGCT
GAGGCTGTAGCAGTCCTGAAAGCTGAACAAGAGAAAGAAGCTCAACATAAAGACCAGACT
GCAGCTCTGCCTTTAGCAGCTGAAGAAACAGCTAATCTGCCTCCTTCTCCACCCCCATCA
CCTGCCTCAGAACAGACTGTCACAGTGGAGGAAGATTTACTTACAGCCTCGAAGATGGAG
TTCCACGATCAACAGGAATTGACTCCCTCTACAGCTGAGCCTTCAGACCAGAAGGAAAAG
GAGTCAGAGAAGCAAAGTAGTCCTGGTGAAGACCTTAAACATGCTGCCTTAGTTTCTCAG
CCAGAGACAACTAAAACTTACCCTGATAAAAAGGACATGCAAGGCACAGAAGAAGAAAAA
GCACCCCTAGCTTTGTTTGGGCACACTCTTGTTGCCAGCCTGGAAGACATGAAACAGAAG
ACAGAACCAAGCCTTGTAGTACCTGGCATTGACCTCCCTAAAGAGCCTCCAACTCCAAAA
GAACAAAAGGACTGGTTCATCGAAATGCCAACGGAAGCAAAAAAGGATGAGTGGGGTTTA
GTTGCCCCCATATCTCCTGGCCCTCTGACTCCCATGAGGGAAAAAGATGTATTTGATGAT
ATCCCAAAATGGGAAGGGAAACAGTTTGATTCTCCCATGCCAAGTCCCTTTCAAGGGGGA
AGCTTCACTCTTCCTTTAGATGTCATGAAGAATGAAATAGTTACAGAAACATCGCCCTTT
GCCCCTGCCTTTTTACAGCCAGATGACAAAAAATCTCTGCAACAAACCAGTGGCCCAGCT
ACTGCCAAAGATAGTTTTAAAATTGAAGAGCCCCATGAGGCTAAACCTGACAAAATGGCA
GAAGCACCACCCTCAGAGGCAATGACCTTACCCAAAGATGCTCACATTCCAGTTGTAGAA
GAACATGTTATGGGGAAAGTTTTAGAGGAAGAAAAGGAGGCCATAAATCAAGAGACTGTG
CAGCAAAGGGATACTTTCACCCCCAGTGGACAGGAACCTATACTTACTGAAAAGGAAACT
GAGCTGAAGCTTGAAGAAAAAACCACCATTTCTGACAAAGAAGCTGTGCCAAAAGAGAGT
AAACCCCCAAAACCTGCAGATGAAGAAATAGGCATAATTCAGACCTCCACAGAGCACACT
TTCTCAGAACAGAAAGACCAAGAGCCTACCACAGATATGTTGAAACAGGACTCGTTCCCT
GTAAGTTTGGAGCAAGCAGTTACAGATTCAGCCATGACCTCTAAAACACTGGAGAAAGCC
ATGACCGAACCATCTGCATTAATTGAAAAGAGCTCAATTCAGGAACTTTTTGAAATGAGA
GTTGATGACAAAGATAAGATTGAAGGAGTTGGAGCTGCAACATCAGCTGAGCTTGATATG
CCATTTTATGAAGATAAATCAGGAATGTCCAAGTACTTTGAAACATCTGCCTTGAAAGAA
GAAGCAACAAAAAGCATTGAGCCAGGCAGTGATTACTATGAACTGAGTGACACTAGAGAA
AGTGTCCATGAGTCTATTGATACCATGTCTCCCATGCATAAAAATGGTGACAAGGAGTTT
CAAACAGGAAAAGAATCCCAGCCCAGTCCTCCAGCACAAGAAGCAGGGTACAGCACTCTC
GCACAGAGTTATCCATCAGATTTACCTGAAGAACCCAGTTCTCCTCAAGAAAGAATGTTC
ACTATTGATCCAAAAGTGTATGGAGAGAAAAGGGACCTCCACAGTAAGAATAAGGATGAT
TTGACCCTTAGCAGGAGTTTAGGACTTGGTGGTAGGTCTGCAATAGAACAAAGAAGCATG
TCAATCAATTTGCCGATGTCTTGCCTAGATTCCATAGCCCTTGGATTTAACTTTGGTCGG
GGACATGATCTTTCTCCTCTGGCTTCCGATATTCTAACCAACACTAGTGGAAGTATGGAT
GAAGGGGATGATTACCTTCCAGCCACCACACCTGCACTGGAGAAAGCCCCTTGCTTCCCT
GTAGAAAGCAAAGAGGAAGAACAGATAGAGAAAGTAAAAGCTACTGGAGAAGAAAGTACT
CAAGCGGAGATATCATGTGAGTCTCCTTTCCTAGCCAAAGATTTTTACAAAAATGGTACT
GTCATGGCACCTGACCTTCCTGAAATGCTAGATCTGGCAGGCACAAGGTCAAGATTGGCT
TCTGTGAGTGCAGATGCTGAGGTTGCCAGGAGGAAATCAGTCCCATCAGAGACTGTGGTT
GAGGATAGTCGTACTGGCTTGCCCCCGGTAACTGATGAAAACCATGTCATTGTAAAAACG
GACAGTCAGCTCGAAGACCTGGGCTACTGTGTGTTCAATAAGTACACAGTCCCATTGCCA
TCACCTGTTCAAGACAGTGAGAATTTATCAGGGGAGAGTGGTACCTTTTACGAAGGCACT
GATGATAAAGTTCGAAGAGATTTGGCCACAGACCTTTCACTGATTGAAGTGAAACTGGCA
GCAGCCGGAAGAGTCAAAGATGAGTTCAGTGTTGACAAAGAAGCATCCGCGCATATCTCT
GGTGACAAATCAGGACTGAGTAAGGAGTTTGACCAAGAGAAGAAAGCTAATGATAGGTTG
GATACTGTACTAGAAAAGAGTGAAGAACATGCTGATTCAAAAGAACATGCCAAGAAAACT
GAAGAGGCTGGTGATGAAATAGAAACATTCGGATTAGGAGTAACCTATGAGCAAGCTTTG
GCCAAAGATTTGTCAATACCAACAGATGCATCCTCTGAGAAAGCAGAGAAGGGTCTTAGT
TCAGTTCCAGAGATAGCTGAGGTAGAACCATCCAAAAAGGTGGAACAAGGTCTGGATTTT
GCTGTCCAGGGTCAACTAGATGTTAAAATTAGTGACTTTGGACAGATGGCTTCAGGGCTA
AACATAGATGATAGAAGGGCAACAGAGCTAAAACTTGAGGCTACACAGGACATGACCCCC
TCATCCAAAGCACCGCAGGAGGCAGATGCATTTATGGGTGTTGAGTCTGGCCACATGAAA
GAAGGCACTAAAGTTAGTGAGACAGAAGTCAAACAGAAGGTGGCCAAGCCTGACTTGGTG
CACCAGGAGGCTGTAGACAAGGAGGAGTCCTATGAATCTAGTGGTGAGCATGAAAGTCTC
ACCATGGAGTCCTTGAAAGCTGATGAGGGCAAGAAGGAAACATCTCCAGAATCATCTCTA
ATTCAAGATGAGATTGCCGTCAAATTGTCAGTGGAAATACCTTGCCCACCTGCTGTTTCA
GAGGCTGATTTAGCCACAGATGAGAGAGCTGATGTCCAGATGGAATTTATTCAGGGGCCA
AAAGAAGAAAGCAAAGAGACCCCAGATATATCCATCACGCCTTCTGATGTTGCAGAGCCA
TTGCATGAAACGATCGTATCTGAACCAGCAGAGATTCAGAGTGAGGAAGAAGAGATAGAA
GCCCAGGGAGAATATGATAAACTGCTCTTCCGCTCAGACACCCTTCAGATAACTGACCTG
GGTGTCTCAGGTGCCAGGGAGGAATTTGTGGAGACCTGCCCAAGTGAACACAAAGGAGTG
ATTGAGTCTGTTGTGACCATCGAGGATGATTTCATCACTGTAGTGCAAACCACAACTGAT
GAAGGGGAGTCAGGGTCCCACAGCGTGCGTTTTGCAGCCCTAGAGCAGCCTGAGGTGGAA
AGGAGACCATCTCCTCATGATGAAGAAGAGTTTGAAGTAGAAGAGGCAGCTGAAGCCCAG
GCAGAACCCAAAGATGGTTCCCCAGAGGCTCCAGCTTCCCCTGAGAGAGAAGAGGTTGCA
CTTTCTGAATATAAGACAGAAACCTATGACGATTACAAAGATGAGACCACCATTGACGAC
TCCATCATGGACGCTGACAGCCTCTGGGTGGACACTCAAGATGATGATAGGAGCATCATG
ACAGAACAGTTAGAAACTATTCCTAAAGAGGAGAAAGCTGAAAAGGAAGCTCGGAGATCA
TCTCTTGAGAAACATAGAAAAGAAAAGCCTTTTAAAACCGGGAGAGGCAGAATTTCCACT
CCTGAAAGAAAAGTAGCTAAAAAGGAACCTAGCACAGTCTCCAGAGATGAAGTGAGAAGG
AAAAAAGCAGTTTATAAGAAGGCTGAACTTGCTAAAAAAACAGAAGTTCAGGCCCACTCT
CCCTCCAGGAAATTCATTTTAAAACCTGCTATCAAATATACTAGACCAACTCATCTCTCC
TGTGTTAAGCGGAAAACCACAGCAGCAGGTGGGGAATCAGCTCTGGCTCCCAGTGTATTT
AAACAGGCAAAGGACAAAGTCTCTGACGGAGTAACCAAGAGCCCAGAAAAGCGCTCTTCT
CTCCCAAGACCTTCCTCCATTCTCCCTCCTCGGCGAGGTGTGTCAGGAGACAGAGATGAG
AATTCCTTCTCTCTCAACAGTTCTATCTCTTCTTCAGCACGGCGGACCACCAGGTCAGAG
CCAATTCGCAGAGCAGGAAAGAGTGGTACCTCAACACCCACTACCCCTGGGTCTACTGCC
ATCACTCCTGGCACCCCACCAAGTTATTCTTCACGCACACCAGGCACTCCTGGAACCCCT
AGCTATCCCAGGACCCCTCACACACCAGGAACCCCCAAGTCTGCCATCTTGGTGCCGAGT
GAGAAGAAGGTCGCCATCATACGTACTCCTCCAAAATCTCCTGCGACTCCCAAGCAGCTT
CGGCTTATTAACCAACCACTGCCAGACCTGAAGAATGTCAAATCCAAAATCGGATCAACA
GACAACATCAAATACCAGCCTAAAGGGGGGCAGGTACAAATTGTTACCAAGAAAATAGAC
CTAAGCCATGTGACATCCAAATGTGGCTCTCTGAAGAACATCGACAGGCCAGGTGGCGGA
CGTGTGAAAATTGAGAGTGTAAAACTAGATTTCAAGGAAAAGGTCCAAGCTAAAGTTGGT
TCTCTTGATAATGCTCATCATGTACCTGGAGGTGGTAATGTCAAGATTGACAGCCAAAAG
TTGAACTTCAGAGAGCATGCTAAAGCCCGTGTGGACCATGGGGCTGAGATCATTACACAG
TCCCCAGGCAGATCCAGCGTGGCATCACCCCGACGACTCAGCAATGTCTCCTCGTCTGGA
AGCATCAACCTGCTCGAATCTCCTCAGCTTGCCACTTTGGCTGAGGATGTCACTGCTGCA
CTCGCTAAGCAGGGCTTGTGA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
U01828

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_12_Locus:
2q34-q35

# Macromolecular_Interacting_Partner_12_SNPs:
rs741006; rs17745550; rs13425372; rs35927101; rs2271252; rs35994200; rs34693874; rs2239672; rs2663644; rs288096; rs2365657; rs2710486; rs2048249; rs1967262; rs288065; rs288081; rs1509470; rs2663656; rs2710476; rs288071; rs288063; rs906831; rs1039826; rs2663649; rs997109; rs288052; rs288094; rs2365659; rs2048250; rs2710474; rs2123701; rs877782; rs1949041; rs2663651; rs169636; rs288068; rs288080; rs10203283; rs7559831; rs2663652; rs11886253; rs4673481; rs10737940; rs1509468; rs2365658; rs1563125; rs2886435; rs288079; rs12475254; rs6435528; rs2710475; rs12694184; rs7603804; rs12993506; rs6756379; rs7566048; rs9917164; rs6435531; rs4673482; rs7593381; rs13412699; rs11899684; rs1509465; rs12986617; rs288055; rs12621170; rs6435529; rs2219085; rs7568431; rs288059; rs2123699; rs6435533; rs6435530; rs12616589; rs6746029; rs13000895; rs11901333; rs2198475; rs2219084; rs7586196; rs6726061; rs9288410; rs10196600; rs7561678; rs288067; rs2198478; rs6716675; rs992991; rs7601095; rs2886436; rs7593377; rs11885999; rs4672554; rs10198751; rs10048829; rs7568354; rs288087; rs10193321; rs9288409; rs2366112; rs9288411; rs1509467; rs17237893; rs10179388; rs16843257; rs12053460; rs11897507; rs288085; rs17317100; rs13404929; rs17316904; rs10497931; rs12990915; rs16842929; rs13432941; rs7594842; rs12694181; rs1509472; rs12986778; rs7594825; rs13025539; rs992029; rs852734; rs12993627; rs16843177; rs12995429; rs16842904; rs1031461; rs10172200; rs12619473; rs13027122; rs16843092; rs16843326; rs10174291; rs17238539; rs1563122; rs993784; rs7594086; rs16843236; rs13384979; rs10514644; rs7595924; rs13022724; rs1396778; rs13022394; rs7576723; rs13392748; rs16843618; rs10737939; rs10207071; rs1509469; rs17237719; rs17236751; rs10173260; rs1828281; rs17317170; rs12620654; rs7567723; rs13382265; rs16843082; rs16843209; rs13014332; rs4673483; rs10514642; rs16842909; rs11686580; rs10208979; rs11904089; rs288077; rs16842895; rs12992468; rs11678041; rs2028893; rs10932301; rs6745316; rs17317114; rs12052799; rs288053; rs16842934; rs16843022; rs7562585; rs16842906; rs11687844; rs7604320; rs7574854; rs13023473; rs962475; rs17238784; rs12694182; rs1563123; rs6733319; rs16843614; rs16842900; rs10932299; rs10169017; rs10196314; rs288057; rs7557645; rs2365661; rs10179969; rs11680789; rs16842908; rs16843060; rs288076; rs288084; rs12993084; rs13399574; rs10514643; rs11896384; rs13000954; rs2710477; rs6752060; rs288064; rs17236116; rs2663648; rs288046; rs2123700; rs10200389; rs16843354; rs16843115; rs2167933; rs16842899; rs11687764; rs6738205; rs7608854; rs1962197; rs17316974; rs6717554; rs1563124; rs12694185; rs10210266; rs17316862; rs13002255; rs13425141; rs16843019; rs7601003; rs6745900; rs9798099; rs7565225; rs7585280; rs9751733; rs11904626; rs13400942; rs16843111; rs4575653; rs288072; rs7559024; rs7574272; rs17237823; rs7576988; rs16842923; rs2663659; rs16843085; rs1355194; rs16843162; rs7561813; rs17308504; rs1396777; rs12105310; rs6761302; rs12613572; rs288075; rs7579596; rs17726953; rs12992067; rs11895827; rs7569410; rs16843097; rs17309518; rs13027599; rs13027724; rs9967799; rs16843329; rs288088; rs2663653; rs2219086; rs10207360; rs16842897; rs6435532; rs16843159; rs16843064; rs288095; rs7563174; rs12623006; rs12996619; rs16843066; rs7576171; rs7575854; rs288078; rs11884711; rs12991864; rs10205924; rs288066; rs16843621; rs6761578; rs12694187; rs7568267; rs2366109; rs16843149; rs7577194; rs6717649; rs16843154; rs16843059; rs13414750; rs16843351; rs7576819; rs7569773; rs17789843; rs7577154; rs2663650; rs12328605; rs288086; rs7589357; rs10204469; rs17237076; rs11890456; rs17317756; rs10165558; rs2710471; rs2710481; rs16843129; rs16843062; rs992028; rs288091; rs288062; rs11885022; rs12618766; rs12327904; rs7561732; rs17309028; rs7589487; rs13423655; rs11887037; rs2365660; rs16843034; rs288089; rs288082; rs16843103; rs7568260; rs10153809; rs6736396; rs7562710; rs288083; rs11884652; rs12694186; rs2710478; rs6728378; rs12612873; rs2198479; rs7601139; rs288045; rs16843118; rs7594469; rs17236857; rs10174634; rs16842992; rs16843138; rs16843052; rs2710480; rs12623404; rs7580512; rs288060; rs2063292; rs17317645; rs12614655; rs11892923; rs6709711; rs288074; rs1355192; rs12993284; rs1858140; rs7595691; rs16843083; rs16843100; rs7577077; rs13432745; rs12622979; rs17733579; rs7576860; rs16843090; rs288048; rs16843121; rs13411087; rs6744370; rs10490754; rs4673479; rs12467717; rs16843170; rs288070; rs1509466; rs16843089; rs11893295; rs13027280; rs2366111; rs16843222; rs16843080; rs6435527; rs7577172; rs12995238; rs13394033; rs4673484; rs2198476; rs9288408; rs11891231; rs6718161; rs2710479; rs288073; rs288093; rs6757315; rs17239083; rs9750637; rs288061; rs13015584; rs16843094; rs10200539; rs13036178; rs16843360; rs16843141; rs16843053; rs17316313; rs12988159; rs12328000; rs1509471; rs10179315; rs288049; rs13419929; rs6751612; rs7576050; rs6740822; rs16843132; rs13033819; rs7576909; rs13386656; rs7574625; rs12997113; rs12612241; rs16843106; rs12615372; rs12621444; rs16843292; rs11677771; rs7591456; rs11900281; rs1509473; rs2710482; rs2268044; rs2191910; rs2286849; rs994862; rs2286850; rs7594601; rs6709925; rs2268042; rs3738935; rs3768822; rs6751280; rs2284359; rs6742070; rs6435535; rs10206817; rs7596811; rs11692075; rs3768816; rs3768828; rs7567257; rs10932305; rs3768833; rs2284360; rs11693208; rs4673486; rs3768823; rs723683; rs2239552; rs3768834; rs2886577; rs985701; rs12614031; rs3768835; rs11691894; rs13423127; rs16843382; rs10197252; rs10205733; rs10189166; rs3768826; rs3768810; rs12613705; rs11682692; rs16843392; rs3768821; rs3768832; rs10174385; rs11889693; rs4673485; rs12618080; rs11891356; rs16843555; rs2663658; rs6724834; rs12619409; rs13424278; rs3768811; rs2300154; rs16843574; rs3886931; rs3768817; rs3768830; rs3820748; rs16843390; rs10196953; rs10490021; rs3768820; rs3768827; rs7577387; rs3820746; rs16843513; rs13419654; rs11891360; rs12618419; rs16843415; rs10165938; rs16843544; rs13419651; rs16843394; rs2663647; rs2300155; rs16843388; rs3835773; rs16843423; rs16843554; rs2663657; rs16843400; rs2710484; rs11677975; rs3768818; rs13422521; rs16843491; rs11678292; rs16843532; rs13392785; rs17745941; rs16843380; rs16843396; rs13385585; rs2710483; rs11691800; rs2239553; rs6435534; rs16824922; rs13409134; rs16843399; rs11684164; rs3754597; rs16843369; rs16843402; rs16843515; rs17745737; rs11884702; rs16843373; rs12619253; rs16843421; rs10208961; rs10804176; rs11889422; rs12614974; rs16843626; rs41265969; rs35915945; rs755708; rs5838179; rs2271251; rs35935403; rs36091461; rs34455059; rs34583170; rs2886576; rs16843008; rs34064885; rs35808242; rs35093990; rs35662315; rs12988648; rs34923473; rs288069; rs35808813; rs34741059; rs5838173; rs11899571; rs16824921; rs288054; rs5838176; rs10172852; rs3036660; rs16843173; rs33942024; rs34971826; rs34459559; rs34614456; rs34300134; rs2254169; rs10167492; rs13022159; rs13014730; rs34128346; rs34382981; rs10176677; rs35974189; rs288047; rs36049687; rs12465033; rs10167417; rs10578247; rs34854469; rs10204207; rs2198477; rs10932303; rs11380312; rs35057451; rs34742959; rs13035694; rs13030241; rs12620800; rs16842990; rs13027312; rs10712020; rs13423045; rs34921243; rs35093853; rs13407504; rs35348313; rs4474826; rs34067699; rs11442090; rs11896606; rs13029522; rs35123976; rs35918308; rs1848689; rs7421429; rs13015411; rs13383482; rs13003498; rs12615261; rs35353054; rs34711845; rs288092; rs35349090; rs34243647; rs5838170; rs7561833; rs34807931; rs288051; rs34923027; rs35388880; rs34779878; rs34018539; rs11464755; rs13399564; rs13005787; rs35302423; rs36101555; rs13412519; rs33975733; rs13000863; rs288058; rs7603837; rs34924200; rs7608830; rs35774901; rs6752348; rs35887391; rs36097634; rs13030060; rs35568286; rs34847298; rs34707864; rs35549936; rs35832475; rs35553764; rs28556312; rs34806748; rs13013173; rs5838175; rs35100420; rs288044; rs35409969; rs1509474; rs35216876; rs6717606; rs13387320; rs12621656; rs13034509; rs10578577; rs34437960; rs34153019; rs35264219; rs13385987; rs35286408; rs34306770; rs16824918; rs34487214; rs36013249; rs35286438; rs34319559; rs34509618; rs1396780; rs35130658; rs35862250; rs34284009; rs11282560; rs35520781; rs10172849; rs4603701; rs12989772; rs2663646; rs35997966; rs13389549; rs10562326; rs1858141; rs28517694; rs2366110; rs12613838; rs36003754; rs34602765; rs34331622; rs34006754; rs34568125; rs34173247; rs35079077; rs35534715; rs35822697; rs35321790; rs34683564; rs34407023; rs1876796; rs34046920; rs11335041; rs34643755; rs34670588; rs6714544; rs16842993; rs34673279; rs16842912; rs925263; rs34636750; rs35053287; rs35467107; rs34640164; rs5838169; rs28375846; rs34156640; rs11450792; rs10189639; rs6725710; rs2663654; rs10523625; rs35558337; rs34210024; rs34952364; rs11896762; rs34610628; rs13035684; rs13016157; rs13026868; rs13012322; rs35755470; rs11320939; rs34884270; rs35018040; rs13034750; rs35299380; rs10707934; rs3036663; rs34041601; rs13400179; rs12989574; rs35280709; rs35418396; rs12328604; rs12617999; rs35241611; rs852733; rs1876797; rs35346315; rs35247318; rs35171323; rs11894000; rs4672555; rs28610349; rs34459550; rs13034500; rs35201759; rs1396779; rs288056; rs13018885; rs28558587; rs13397877; rs1396781; rs10189911; rs35249570; rs35724975; rs34327548; rs17237202; rs34632100; rs11395434; rs12989597; rs1848690; rs34695079; rs7571000; rs10578576; rs35620787; rs34244744; rs35482784; rs34046964; rs13385248; rs35111427; rs10167164; rs12989474; rs34850994; rs34811576; rs35067972; rs7590615; rs34128824; rs10207186; rs35846319; rs34667966; rs34603557; rs28416381; rs34344578; rs34382912; rs34702908; rs35174339; rs13020911; rs12620673; rs36089216; rs35793101; rs28472776; rs13032935; rs10548230; rs13015095; rs10167168; rs7589567; rs10594008; rs10173056; rs13017741; rs6734077; rs13008317; rs35378786; rs35289078; rs34968429; rs34781471; rs10167280; rs34783349; rs34445752; rs13005989; rs34928174; rs34150403; rs28438734; rs35305939; rs3058731; rs35264850; rs34488838; rs35075084; rs11340703; rs852732; rs288090; rs6722585; rs5838172; rs12996265; rs34158213; rs36230005; rs11297017; rs35664672; rs13407668; rs13423670; rs288043; rs11458359; rs35337436; rs35731221; rs13027957; rs3036661; rs34951382; rs12992342; rs35242434; rs35806520; rs11309869; rs13025538; rs13025402; rs35322433; rs10178950; rs34379988; rs16843249; rs35966407; rs34628265; rs5838178; rs35267295; rs13010146; rs35273017; rs10183315; rs13034521; rs5838177; rs35426033; rs10648516; rs35291809; rs36086699; rs35320310; rs2710472; rs1848691; rs17308202; rs11686346; rs2060948; rs34204214; rs35287109; rs11896307; rs35306148; rs35703041; rs13418978; rs35781477; rs11890084; rs5838167; rs6714799; rs6738311; rs34763812; rs28612937; rs34006211; rs1355193; rs13403759; rs35750517; rs288050; rs35066079; rs34124912; rs11898015; rs2710473; rs28650191; rs2663655; rs34091127; rs34608863; rs10167520; rs34184923; rs34325206; rs4019746; rs34397776; rs35444480; rs5838171; rs1976583; rs35275455; rs4375801; rs12988428; rs34117203; rs34333176; rs34659853; rs34005315; rs34439015; rs11389534; rs3768831; rs35842786; rs2366113; rs35009092; rs993791; rs13021458; rs35700462; rs6723367; rs35266859; rs34534060; rs3831766; rs11460425; rs2268043; rs34829112; rs2710485; rs10611077; rs7567872; rs3768829; rs13021688; rs35581436; rs10432440; rs10654750; rs12995197; rs34351420; rs2268045; rs34542257; rs41526653; rs34076836; rs33967846; rs28666486; rs11389149; rs12995186; rs34254147; rs11901955; rs3768824; rs34459067; rs28435689; rs35934344; rs35920076; rs13031548; rs7596850; rs13428159; rs41265967; rs3835777; rs34931377; rs35542268; rs4392185; rs35579471; rs41405552; rs34602590; rs12328955; rs3768819; rs34892360; rs5838180; rs34422785; rs2191911; rs35758041; rs35368898; rs28758270; rs34360891; rs13021647; rs12995155; rs13416024; rs41493552; rs35324449; rs34156547; rs3217099; rs34320587; rs3036697; rs34217573; rs13407717; rs35784941; rs35411820; rs35433095; rs35227040; rs35564310; rs35579131; rs10631673; rs10186192; rs10201740; rs11682229; rs11687043; rs11692345; rs11884784; rs11892713; rs11898077; rs11900413; rs13391766; rs13429183; rs16843125; rs16843453; rs16843651; rs2191912; rs2215624; rs2215625; rs2268046; rs3768812; rs3768813; rs3768814; rs3768815; rs3820747; rs6435536; rs6720659; rs6741753; rs6749066; rs6761283; rs741007; rs7563521

# Macromolecular_Interacting_Partner_12_General_References:
8294038; 2481044; 2455776

# Macromolecular_Interacting_Partner_12_References:
12775713

# Macromolecular_Interacting_Partner_13_ID:
5564

# Macromolecular_Interacting_Partner_13_Name:
Glucose-6-phosphate 1-dehydrogenase

# Macromolecular_Interacting_Partner_13_Synonyms:
G6PD

# Macromolecular_Interacting_Partner_13_Gene_Name:
G6PD

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Glucose6phosphate 1dehydrogenase
MAEQVALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGL
LPENTFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQR
LNSHMNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSS
DRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEP
FGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQA
NNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGK
ALNERKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESEL
DLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPI
PYIYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
515

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
59257

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
6.84

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  glucose-6-phosphate 1-dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_13_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_13_Specific_Function:
Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power

# Macromolecular_Interacting_Partner_13_Pathway:
map00030  Pentose phosphate pathway;
 map00480  Glutathione metabolism

# Macromolecular_Interacting_Partner_13_Reaction:
D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF02781:G6PD_C;
PF00479:G6PD_N

# Macromolecular_Interacting_Partner_13_Signals:
None

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
EC 1.1.1.49

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
31543

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
G6PD_HUMAN (P11413)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
G6PD

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
G6PD

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:4057

# Macromolecular_Interacting_Partner_13_PDB_ID:
1QKI

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>1548 bp
ATGGCAGAGCAGGTGGCCCTGAGCCGGACCCACGTGTGCGGGATCCTGCGGGAAGAGCTT
TTCCAGGGCGATGCCTTCCATCAGTCGGATACACACATATTCATCATCATGGGTGCATCG
GGTGACCTGGCCAAGAAGAAGATCTACCCCACCATCTGGTGGCTGTTCCGGGATGGCCTT
CTGCCCGAAAACACCTTCATCGTGGGCTATGCCCGTTCCCGCCTCACAGTGGCTGACATC
CGCAAACAGAGTGAGCCCTTCTTCAAGGCCACCCCAGAGGAGAAGCTCAAGCTGGAGGAC
TTCTTTGCCCGCAACTCCTATGTGGCTGGCCAGTACGATGATGCAGCCTCCTACCAGCGC
CTCAACAGCCACATGAATGCCCTCCACCTGGGGTCACAGGCCAACCGCCTCTTCTACCTG
GCCTTGCCCCCGACCGTCTACGAGGCCGTCACCAAGAACATTCACGAGTCCTGCATGAGC
CAGATAGGCTGGAACCGCATCATCGTGGAGAAGCCCTTCGGGAGGGACCTGCAGAGCTCT
GACCGGCTGTCCAACCACATCTCCTCCCTGTTCCGTGAGGACCAGATCTACCGCATCGAC
CACTACCTGGGCAAGGAGATGGTGCAGAACCTCATGGTGCTGAGATTTGCCAACAGGATC
TTCGGCCCCATCTGGAACCGGGACAACATCGCCTGCGTTATCCTCACCTTCAAGGAGCCC
TTTGGCACTGAGGGTCGCGGGGGCTATTTCGATGAATTTGGGATCATCCGGGACGTGATG
CAGAACCACCTACTGCAGATGCTGTGTCTGGTGGCCATGGAGAAGCCCGCCTCCACCAAC
TCAGATGACGTCCGTGATGAGAAGGTCAAGGTGTTGAAATGCATCTCAGAGGTGCAGGCC
AACAATGTGGTCCTGGGCCAGTACGTGGGGAACCCCGATGGAGAGGGCGAGGCCACCAAA
GGGTACCTGGACGACCCCACGGTGCCCCGCGGGTCCACCACCGCCACTTTTGCAGCCGTC
GTCCTCTATGTGGAGAATGAGAGGTGGGATGGGGTGCCCTTCATCCTGCGCTGCGGCAAG
GCCCTGAACGAGCGCAAGGCCGAGGTGAGGCTGCAGTTCCATGATGTGGCCGGCGACATC
TTCCACCAGCAGTGCAAGCGCAACGAGCTGGTGATCCGCGTGCAGCCCAACGAGGCCGTG
TACACCAAGATGATGACCAAGAAGCCGGGCATGTTCTTCAACCCCGAGGAGTCGGAGCTG
GACCTGACCTACGGCAACAGATACAAGAACGTGAAGCTCCCTGACGCCTACGAGCGCCTC
ATCCTGGACGTCTTCTGCGGGAGCCAGATGCACTTCGTGCGCAGCGACGAGCTCCGTGAG
GCCTGGCGTATTTTCACCCCACTGCTGCACCAGATTGAGCTGGAGAAGCCCAAGCCCATC
CCCTATATTTATGGCAGCCGAGGCCCCACGGAGGCAGACGAGCTGATGAAGAGAGTGGGT
TTCCAGTATGAGGGCACCTACAAGTGGGTGAACCCCCACAAGCTCTGA

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
X03674

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_13_Locus:
Xq28

# Macromolecular_Interacting_Partner_13_SNPs:
rs1050829; rs1050828; rs2230037; rs2230036; rs1050757; rs743544; rs2472393; rs2472394; rs762516; rs2071429; rs5986991; rs2515906; rs34193178; rs5030870; rs5030869; rs11555344; rs5030868; rs5030872; rs1050773; rs1050830; rs1063529; rs1050831; rs1050774; rs5986990; rs34253245; rs11544439; rs11797720; rs35972742; rs2515904; rs7064060; rs28613671; rs35948381; rs35965297; rs28480464; rs5986875; rs2515905; rs34705926; rs7881468; rs762515; rs2515685; rs34859682; rs28587726; rs762517; rs3216174; rs28604320; rs2515910; rs6643679; rs12389569; rs12389568; rs12393550; rs6643678; rs34233392; rs1050827; rs1894260; rs3021074; rs4256746; rs5986992; rs6643675; rs6643680

# Macromolecular_Interacting_Partner_13_General_References:
3515319; 2428611; 1889820; 8733135; 2758468; 8466644; 1874446; 12665801; 12524354; 3012556; 3126064; 6696761; 2910917; 7857286; 8364584; 10745013; 11857737; 3446582; 2836867; 3393536; 1611091; 2912069; 1945893; 1303180; 1303182; 8490627; 8193373; 7959695; 7825590; 8533762; 7858267; 9452072

# Macromolecular_Interacting_Partner_13_References:
12234842; 12475725; 16375719

# Macromolecular_Interacting_Partner_14_ID:
7623

# Macromolecular_Interacting_Partner_14_Name:
Insulin-like growth factor-binding protein 3 precursor

# Macromolecular_Interacting_Partner_14_Synonyms:
IGFBP-3; IBP- 3; IGF-binding protein 3

# Macromolecular_Interacting_Partner_14_Gene_Name:
IGFBP3

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>Insulinlike growth factorbinding protein 3 precursor
MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAE
LVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAV
SRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHA
KDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNC
DKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
291

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
31674

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
8.78

# Macromolecular_Interacting_Partner_14_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  growth factor binding
Function:  insulin-like growth factor binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of growth
Process:  regulation of cell growth
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_14_General_Function:
Not Available

# Macromolecular_Interacting_Partner_14_Specific_Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors

# Macromolecular_Interacting_Partner_14_Pathway:
Not Available

# Macromolecular_Interacting_Partner_14_Reaction:
Not Available

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF00219:IGFBP;
PF00086:Thyroglobulin_1

# Macromolecular_Interacting_Partner_14_Signals:
1-27

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
183116

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
IBP3_HUMAN (P17936)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
IGFBP3

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
IGFBP3

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:5472

# Macromolecular_Interacting_Partner_14_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>876 bp
ATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGCTGGTGCTGCTCCGC
GGGCCGCCGGTGGCGCGGGCTGGCGCGAGCTCGGGGGGCTTGGGTCCCGTGGTGCGCTGC
GAGCCGTGCGACGCGCGTGCACTGGCCCAGTGCGCGCCTCCGCCCGCCGTGTGCGCGGAG
CTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGAGCGAGGGCCAGCCG
TGCGGCATCTACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAG
GCGCGACCGCTGCAGGCGCTGCTGGACGGCCGCGGGCTCTGCGTCAACGCTAGTGCCGTC
AGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGAAATGCTAGTGAGTCG
GAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTG
TCTGATCCCAAGTTCCACCCCCTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCT
AAAGACAGCCAGCGCTACAAAGTTGACTACGAGTCTCAGAGCACAGATACCCAGAACTTC
TCCTCCGAGTCCAAGCGGGAGACAGAATATGGTCCCTGCCGTAGAGAAATGGAAGACACA
CTGAATCACCTGAAGTTCCTCAATGTGCTGAGTCCCAGGGGTGTACACATTCCCAACTGT
GACAAGAAGGGATTTTATAAGAAAAAGCAGTGTCGCCCTTCCAAAGGCAGGAAGCGGGGC
TTCTGCTGGTGTGTGGATAAGTATGGGCAGCCTCTCCCAGGCTACACCACCAAGGGGAAG
GAGGACGTGCACTGCTACAGCATGCAGAGCAAGTAG

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
M31159

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_14_Locus:
7p13-p12

# Macromolecular_Interacting_Partner_14_SNPs:
rs9282734; rs2854746; rs6950868; rs6670; rs2453840; rs2453839; rs34505796; rs35496550; rs35751739; rs34460927; rs34835646; rs3110697; rs6413441; rs6950802; rs2854747; rs6953668; rs33979592; rs2471551; rs12540724; rs3793345; rs2453837; rs35890775; rs34508316; rs34678704; rs10255707; rs34091405; rs17847673; rs1800906; rs35052563; rs34876509; rs34463602; rs2854750; rs35440925; rs34672517; rs9282735; rs10282088; rs11765572; rs10252403; rs2132570; rs13223993; rs10238613; rs2132572; rs2132571; rs13241830; rs35709394; rs35258778; rs34087654; rs34122177; rs34480712; rs34077804; rs3763500; rs2854744; rs35712717; rs17847676; rs34257987; rs34239916; rs34663167; rs35925180; rs2471549; rs34735423; rs11537920; rs11537915; rs9911; rs11537916; rs11537919; rs1050566; rs34735308; rs11537917; rs35704214; rs34930524; rs35689043; rs2515697; rs2854749; rs34515169; rs34833729; rs17847674; rs2645039; rs34988007; rs3110696; rs35683959; rs5883949; rs34331516; rs34014638; rs2645038; rs34898986; rs35350851; rs2645037; rs13230567; rs35872082; rs34720178; rs2854751; rs34424795; rs2854748; rs35855621; rs35610649; rs11292609; rs34881353; rs34006338; rs4302754; rs34533777; rs34351332; rs35017224; rs2854745; rs34097876; rs34058026; rs34939676; rs35533791; rs35919935; rs2645036; rs35300175; rs11773396; rs10230447; rs12671457; rs12671484; rs12702181; rs2088300; rs2088301; rs2270628; rs2453836; rs2515696; rs885555; rs903889; rs924140

# Macromolecular_Interacting_Partner_14_General_References:
2464130; 1695633; 7508771; 12853948; 1697583; 14561895

# Macromolecular_Interacting_Partner_14_References:
12505887; 15021445; 15941949; 16368782

# Macromolecular_Interacting_Partner_15_ID:
7682

# Macromolecular_Interacting_Partner_15_Name:
Interleukin-2 precursor

# Macromolecular_Interacting_Partner_15_Synonyms:
IL-2; T-cell growth factor; TCGF; Aldesleukin

# Macromolecular_Interacting_Partner_15_Gene_Name:
IL2

# Macromolecular_Interacting_Partner_15_Protein_Sequence:
>Interleukin2 precursor
MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRML
TFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSE
TTFMCEYADETATIVEFLNRWITFCQSIISTLT

# Macromolecular_Interacting_Partner_15_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_15_Molecular_Weight:
17628

# Macromolecular_Interacting_Partner_15_Theoretical_pI:
7.95

# Macromolecular_Interacting_Partner_15_GO_Classification:
>>>
Function:  growth factor activity
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interleukin-2 receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_15_General_Function:
Not Available

# Macromolecular_Interacting_Partner_15_Specific_Function:
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells

# Macromolecular_Interacting_Partner_15_Pathway:
Not Available

# Macromolecular_Interacting_Partner_15_Reaction:
Not Available

# Macromolecular_Interacting_Partner_15_Pfam_Domain_Function:
PF00715:IL2

# Macromolecular_Interacting_Partner_15_Signals:
1-20

# Macromolecular_Interacting_Partner_15_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_15_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_15_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_15_GenBank_ID_Protein:
5729676

# Macromolecular_Interacting_Partner_15_SwissProt_ID:
IL2_HUMAN (P60568)

# Macromolecular_Interacting_Partner_15_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_15_Genecard_id:
IL2

# Macromolecular_Interacting_Partner_15_Geneatlas_id:
IL2

# Macromolecular_Interacting_Partner_15_hgnc_id:
HGNC:6001

# Macromolecular_Interacting_Partner_15_PDB_ID:
1PW6

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_15_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_15_Gene_Sequence:
>462 bp
ATGTACAGGATGCAACTCCTGTCTTGCATTGCACTAAGTCTTGCACTTGTCACAAACAGT
GCACCTACTTCAAGTTCTACAAAGAAAACACAGCTACAACTGGAGCATTTACTGCTGGAT
TTACAGATGATTTTGAATGGAATTAATAATTACAAGAATCCCAAACTCACCAGGATGCTC
ACATTTAAGTTTTACATGCCCAAGAAGGCCACAGAACTGAAACATCTTCAGTGTCTAGAA
GAAGAACTCAAACCTCTGGAGGAAGTGCTAAATTTAGCTCAAAGCAAAAACTTTCACTTA
AGACCCAGGGACTTAATCAGCAATATCAACGTAATAGTTCTGGAACTAAAGGGATCTGAA
ACAACATTCATGTGTGAATATGCTGATGAGACAGCAACCATTGTAGAATTTCTGAACAGA
TGGATTACCTTTTGTCAAAGCATCATCTCAACACTGACTTGA

# Macromolecular_Interacting_Partner_15_GenBank_ID_Gene:
J00264

# Macromolecular_Interacting_Partner_15_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_15_Locus:
4q26-q27

# Macromolecular_Interacting_Partner_15_SNPs:
rs3087209; rs2069763; rs2069778; rs2069769; rs2069764; rs2069779; rs1479920; rs2069768; rs2069765; rs1479921; rs2069771; rs2069772; rs2069773; rs2069770; rs2069777; rs2069776; rs2069762; rs2067006; rs2069774; rs1479922; rs11575812; rs10019970; rs11575810; rs1051753; rs34762647; rs35084452; rs2069767; rs34501152; rs11575807; rs41304870; rs33988980; rs34863848; rs34419809; rs2448491; rs2069766; rs11575808; rs2069760; rs2069775; rs11575811; rs36215455; rs2069780; rs36215457; rs36215454; rs11575813; rs2069761; rs35007569; rs36215456; rs35104399; rs10027390; rs11932411; rs13435525; rs1479923; rs1479924; rs2219865; rs3136534; rs4833248

# Macromolecular_Interacting_Partner_15_General_References:
6330695; 6403867; 6312994; 6306584; 6608729; 6324170; 7722480; 8824916; 3264184; 3491296; 6333684; 2793860; 3500515; 1631562; 1510960; 7529123

# Macromolecular_Interacting_Partner_15_References:
12635532; 16091484; 16426146

# Macromolecular_Interacting_Partner_16_ID:
7694

# Macromolecular_Interacting_Partner_16_Name:
Peroxisome proliferator-activated receptor alpha

# Macromolecular_Interacting_Partner_16_Synonyms:
PPAR-alpha

# Macromolecular_Interacting_Partner_16_Gene_Name:
PPARA

# Macromolecular_Interacting_Partner_16_Protein_Sequence:
>Peroxisome proliferatoractivated receptor alpha
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY

# Macromolecular_Interacting_Partner_16_Number_of_Residues:
468

# Macromolecular_Interacting_Partner_16_Molecular_Weight:
52226

# Macromolecular_Interacting_Partner_16_Theoretical_pI:
6.20

# Macromolecular_Interacting_Partner_16_GO_Classification:
>>>
Function:  steroid hormone receptor activity
Function:  transcription factor activity
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_16_General_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Specific_Function:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids

# Macromolecular_Interacting_Partner_16_Pathway:
Not Available

# Macromolecular_Interacting_Partner_16_Reaction:
Not Available

# Macromolecular_Interacting_Partner_16_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_16_Signals:
None

# Macromolecular_Interacting_Partner_16_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_16_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_16_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_16_GenBank_ID_Protein:
307341

# Macromolecular_Interacting_Partner_16_SwissProt_ID:
PPARA_HUMAN (Q07869)

# Macromolecular_Interacting_Partner_16_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_16_Genecard_id:
PPARA

# Macromolecular_Interacting_Partner_16_Geneatlas_id:
PPARA

# Macromolecular_Interacting_Partner_16_hgnc_id:
HGNC:9232

# Macromolecular_Interacting_Partner_16_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_16_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_16_Gene_Sequence:
>1407 bp
ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAG
AGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGGAAACATCCAAGAGATTTCGCAATCC
ATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT
CCTGGCTCAGATGGCTCGGTCATCACGGACACGCTTTCACCAGCTTCGAGCCCCTCCTCG
GTGACTTATCCTGTGGTCCCCGGCAGCGTGGACGAGTCTCCCAGTGGAGCATTGAACATC
GAATGTAGAATCTGCGGGGACAAGGCCTCAGGCTATCATTACGGAGTCCACGCGTGTGAA
GGCTGCAAGGGCTTCTTTCGGCGAACGATTCGACTCAAGCTGGTGTATGACAAGTGCGAC
CGCAGCTGCAAGATCCAGAAAAAGAACAGAAACAAATGCCAGTATTGTCGATTTCACAAG
TGCCTTTCTGTCGGGATGTCACACAACGCGATTCGTTTTGGACGAATGCCAAGATCTGAG
AAAGCAAAACTGAAAGCAGAAATTCTTACCTGTGAACATGACATAGAAGATTCTGAAACT
GCAGATCTCAAATCTCTGGCCAAGAGAATCTACGAGGCCTACTTGAAGAACTTCAACATG
AACAAGGTCAAAGCCCGGGTCATCCTCTCAGGAAAGGCCAGTAACAATCCACCTTTTGTC
ATACATGATATGGAGACACTGTGTATGGCTGAGAAGACGCTGGTGGCCAAGCTGGTGGCC
AATGGCATCCAGAACAAGGAGGTGGAGGTCCGCATCTTTCACTGCTGCCAGTGCACGTCA
GTGGAGACCGTCACGGAGCTCACGGAATTCGCCAAGGCCATCCCAGCGTTCGCAAACTTG
GACCTGAACGATCAAGTGACATTGCTAAAATACGGAGTTTATGAGGCCATATTCGCCATG
CTGTCTTCTGTGATGAACAAAGACGGGATGCTGGTAGCGTATGGAAATGGGTTTATAACT
CGTGAATTCCTAAAAAGCCTAAGGAAACCGTTCTGTGATATCATGGAACCCAAGTTTGAT
TTTGCCATGAAGTTCAATGCACTGGAACTGGATGACAGTGATATCTCCCTTTTTGTGGCT
GCTATCATTTGCTGTGGAGATCGTCCTGGCCTTCTAAACGTAGGACACATTGAAAAAATG
CAGGAGGGTATTGTACATGTGCTCAGACTCCACCTGCAGAGCAACCACCCGGACGATATC
TTTCTCTTCCCAAAACTTCTTCAAAAAATGGCAGACCTCCGGCAGCTGGTGACGGAGCAT
GCGCAGCTGGTGCAGATCATCAAGAAGACGGAGTCGGATGCTGCGCTGCACCCGCTACTG
CAGGAGATCTACAGGGACATGTACTGA

# Macromolecular_Interacting_Partner_16_GenBank_ID_Gene:
L02932

# Macromolecular_Interacting_Partner_16_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_16_Locus:
22q12-q13.1|22q13.31

# Macromolecular_Interacting_Partner_16_SNPs:
rs1800206; rs1800234; rs1800204; rs1800235; rs4253773; rs135547; rs129600; rs4253681; rs4253652; rs135552; rs135539; rs135542; rs4253655; rs12330015; rs9627046; rs135538; rs4253663; rs7364220; rs4253620; rs4253698; rs4253781; rs9626729; rs4253758; rs4253699; rs4253630; rs4253682; rs4253703; rs1555208; rs4253701; rs4253622; rs4253704; rs135549; rs4253665; rs4253686; rs4253792; rs6008259; rs4253702; rs4253669; rs135550; rs135543; rs4253621; rs4253788; rs4253678; rs4253695; rs4253791; rs5769177; rs4253674; rs4253671; rs4253641; rs4253624; rs5766696; rs4253639; rs4253618; rs7286168; rs4253786; rs4253784; rs4253651; rs4253757; rs4253800; rs8138102; rs4253635; rs4253670; rs4253789; rs11704856; rs4253660; rs4253645; rs9626736; rs4253797; rs135540; rs4253638; rs4253694; rs8135690; rs4253633; rs4253627; rs4253642; rs4253696; rs4253656; rs4253706; rs4253659; rs4253672; rs4253691; rs4253667; rs9306498; rs5766698; rs4253688; rs4253623; rs4253634; rs4253801; rs1055659; rs135548; rs4253687; rs4253707; rs4253646; rs6008970; rs4253664; rs4253643; rs4253700; rs4253668; rs135555; rs4253685; rs4253640; rs6008976; rs7287085; rs4253705; rs3892755; rs4253661; rs4253626; rs4253637; rs4253658; rs4253629; rs4253782; rs4253647; rs7289836; rs4253679; rs135551; rs4253793; rs4253617; rs4253692; rs4253631; rs4253644; rs4253625; rs9306499; rs4253790; rs4253787; rs4253683; rs4253619; rs4253662; rs4253657; rs5769178; rs4253756; rs4253684; rs4253636; rs135554; rs4253785; rs4253628; rs9626737; rs4253780; rs4253654; rs4253677; rs761543; rs4253783; rs4253648; rs11704979; rs4253680; rs4253616; rs9626814; rs4253653; rs4253693; rs4253673; rs4253632; rs4253650; rs4253689; rs11913649; rs4253666; rs4823902; rs11704508; rs5769243; rs10427717; rs8135547; rs9680739; rs8139731; rs17661656; rs3747246; rs41367645; rs17661718; rs9306500; rs5766804; rs135553; rs41388244; rs9615264; rs16994933; rs41427746; rs16994915; rs6007981; rs17241878; rs10154348; rs12162684; rs11705154; rs11703495; rs135541; rs12160659; rs7287027; rs4823586; rs6009111; rs41378347; rs12169296; rs135545; rs1134224; rs10775794; rs11703746; rs135536; rs9680676; rs12169290; rs9627268; rs5769366; rs17241885; rs7288994; rs9627100; rs7289495; rs1055657; rs6009081; rs135546; rs1800246; rs5767743; rs4253762; rs4253778; rs4253690; rs4823613; rs4253769; rs4253751; rs6008197; rs6519979; rs4253761; rs4253747; rs4253730; rs4253775; rs4253713; rs4253719; rs4253750; rs4253764; rs4253765; rs4253776; rs4253729; rs4253709; rs4253712; rs4253760; rs4253728; rs11090819; rs4253737; rs4253770; rs4253777; rs2336904; rs4253711; rs4253754; rs4253798; rs4253748; rs4253727; rs4253723; rs4253710; rs4253714; rs6008160; rs4253708; rs4253718; rs4253774; rs4253722; rs4253767; rs4253732; rs5766741; rs4253726; rs4253799; rs5767700; rs7364297; rs4253736; rs4253794; rs4253752; rs4253731; rs4253766; rs4253721; rs4253717; rs4253742; rs4253744; rs4253697; rs4253771; rs4253746; rs4253725; rs4253739; rs4253720; rs4253738; rs4253755; rs1800245; rs4253795; rs4253716; rs4253735; rs4253734; rs5766743; rs4253779; rs4253741; rs4253753; rs6007662; rs4253768; rs4253743; rs4253745; rs4253772; rs4253763; rs4253724; rs4253759; rs4253733; rs4253715; rs8139794; rs4253740; rs4253749; rs8139663; rs41397552; rs11090791; rs11702902; rs11090817; rs6008123; rs7291727; rs5769175; rs5767636; rs9615238; rs5767560; rs5766734; rs6008126; rs5767633; rs11090818; rs8140236; rs12170204; rs9626730; rs11705483; rs11913971; rs7292459; rs5767634; rs4823477; rs6413511; rs1800243; rs1800242; rs9615759; rs1042311; rs5767686; rs1800236; rs12167302; rs9615163; rs41418950; rs34666721; rs5769287; rs35328780; rs7292112; rs11383159; rs7364140; rs5769365; rs34148860; rs5845740; rs35404482; rs35249750; rs41403648; rs35988564; rs6009112; rs5845739; rs36096470; rs41532849; rs881740; rs9615524; rs7286871; rs12484245; rs13053358; rs11538240; rs35966870; rs34896841; rs35838035; rs10643430; rs13053293; rs5767779; rs12171095; rs41479847; rs28772875; rs6009058; rs4592961; rs9627007; rs34109484; rs12159525; rs12170381; rs5845741; rs135544; rs41406451; rs35398060; rs28369325; rs5769129; rs12160049; rs34857047; rs12159225; rs6008042; rs7364165; rs10561065; rs7289761; rs5769184; rs9626764; rs12159821; rs5766682; rs41362646; rs41465647; rs3840962; rs5769088; rs41371446; rs2238833; rs4823487; rs9626756; rs7290774; rs41368348; rs5769276; rs34001104; rs35552991; rs28716636; rs13055301; rs5767424; rs12167354; rs1055658; rs41477146; rs5769364; rs36096495; rs5769356; rs35281820; rs35038216; rs41371949; rs5769142; rs11703765; rs35808855; rs6009014; rs41489145; rs9626751; rs135537; rs41355347; rs34437230; rs9615534; rs6007965; rs12159097; rs9615784; rs11344804; rs5769219; rs9615523; rs16994976; rs9626716; rs28895660; rs41329344; rs35345592; rs41489148; rs1800244; rs13054427; rs11912612; rs11703766; rs36124248; rs12166902; rs6008974; rs13055320; rs5769112; rs41332048; rs12169623; rs5769206; rs36074474; rs35436527; rs13056945; rs8139926; rs9627217; rs6008089; rs10570542; rs34977841; rs11325484; rs35637220; rs9615694; rs17847852; rs4365564; rs5767667; rs8135879; rs12166737; rs5767617; rs5766714; rs9626745; rs2336905; rs6008193; rs9615695; rs7290878; rs1973929; rs28875881; rs41526048; rs35528985; rs12168403; rs34108706; rs34716781; rs9626811; rs41461946; rs12168939; rs6008129; rs34902389; rs12166868; rs10563623; rs10427969; rs8141725; rs4365565; rs5767650; rs34142992; rs9627047; rs7290473; rs5767708; rs6008149; rs34052175; rs11703314; rs6008161; rs10593071; rs35418581; rs11445888; rs35658961; rs34873839; rs10658167; rs41497148; rs35027666; rs6008116; rs34774436; rs11270575; rs34036883; rs35700219; rs6008093; rs6007639; rs13057868; rs28669215; rs11332243; rs41343752; rs28508200; rs2283673; rs5767618; rs28786744; rs10591809; rs12170430; rs12168830; rs12167549; rs34858419; rs13058348; rs8141442; rs6008191; rs6008096; rs5767763; rs35145000; rs28584795; rs6007673; rs7286742; rs12168937; rs28828403; rs35615646; rs34406573; rs13058552; rs6008130; rs12166556; rs13056831; rs9626742; rs34363509; rs9615487; rs5767320; rs34775146; rs9626709; rs12157295; rs10154668; rs1053332; rs11705226; rs12106599; rs12159251; rs135556; rs135557; rs135559; rs135560; rs135561; rs135562; rs14842; rs14843; rs16995065; rs16995067; rs16995069; rs5767842; rs6008923; rs717926; rs7284616; rs7289611; rs7291028; rs9626816; rs9626823; rs9627278; rs9627280; rs9627281; rs9627287

# Macromolecular_Interacting_Partner_16_General_References:
7684926; 7981125; 8993548; 10591208; 9238002; 10681503

# Macromolecular_Interacting_Partner_16_References:
12482595; 12562454; 12757836; 14648378

# Macromolecular_Interacting_Partner_17_ID:
5688

# Macromolecular_Interacting_Partner_17_Name:
Estrogen receptor beta

# Macromolecular_Interacting_Partner_17_Synonyms:
ER-beta

# Macromolecular_Interacting_Partner_17_Gene_Name:
ESR2

# Macromolecular_Interacting_Partner_17_Protein_Sequence:
>Estrogen receptor beta
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ

# Macromolecular_Interacting_Partner_17_Number_of_Residues:
530

# Macromolecular_Interacting_Partner_17_Molecular_Weight:
59217

# Macromolecular_Interacting_Partner_17_Theoretical_pI:
8.55

# Macromolecular_Interacting_Partner_17_GO_Classification:
>>>
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  steroid binding
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_17_General_Function:
Not Available

# Macromolecular_Interacting_Partner_17_Specific_Function:
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual

# Macromolecular_Interacting_Partner_17_Pathway:
Not Available

# Macromolecular_Interacting_Partner_17_Reaction:
Not Available

# Macromolecular_Interacting_Partner_17_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_17_Signals:
None

# Macromolecular_Interacting_Partner_17_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_17_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_17_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_17_GenBank_ID_Protein:
2911152

# Macromolecular_Interacting_Partner_17_SwissProt_ID:
ESR2_HUMAN (Q92731)

# Macromolecular_Interacting_Partner_17_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_17_Genecard_id:
ESR2

# Macromolecular_Interacting_Partner_17_Geneatlas_id:
ESR2

# Macromolecular_Interacting_Partner_17_hgnc_id:
HGNC:3468

# Macromolecular_Interacting_Partner_17_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_17_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_17_Gene_Sequence:
>1593 bp
ATGGATATAAAAAACTCACCATCTAGCCTTAATTCTCCTTCCTCCTACAACTGCAGTCAA
TCCATCTTACCCCTGGAGCACGGCTCCATATACATACCTTCCTCCTATGTAGACAGCCAC
CATGAATATCCAGCCATGACATTCTATAGCCCTGCTGTGATGAATTACAGCATTCCCAGC
AATGTCACTAACTTGGAAGGTGGGCCTGGTCGGCAGACCACAAGCCCAAATGTGTTGTGG
CCAACACCTGGGCACCTTTCTCCTTTAGTGGTCCATCGCCAGTTATCACATCTGTATGCG
GAACCTCAAAAGAGTCCCTGGTGTGAAGCAAGATCGCTAGAACACACCTTACCTGTAAAC
AGAGAGACACTGAAAAGGAAGGTTAGTGGGAACCGTTGCGCCAGCCCTGTTACTGGTCCA
GGTTCAAAGAGGGATGCTCACTTCTGCGCTGTCTGCAGCGATTACGCATCGGGATATCAC
TATGGAGTCTGGTCGTGTGAAGGATGTAAGGCCTTTTTTAAAAGAAGCATTCAAGGACAT
AATGATTATATTTGTCCAGCTACAAATCAGTGTACAATCGATAAAAACCGGCGCAAGAGC
TGCCAGGCCTGCCGACTTCGGAAGTGTTACGAAGTGGGAATGGTGAAGTGTGGCTCCCGG
AGAGAGAGATGTGGGTACCGCCTTGTGCGGAGACAGAGAAGTGCCGACGAGCAGCTGCAC
TGTGCCGGCAAGGCCAAGAGAAGTGGCGGCCACGCGCCCCGAGTGCGGGAGCTGCTGCTG
GACGCCCTGAGCCCCGAGCAGCTAGTGCTCACCCTCCTGGAGGCTGAGCCGCCCCATGTG
CTGATCAGCCGCCCCAGTGCGCCCTTCACCGAGGCCTCCATGATGATGTCCCTGACCAAG
TTGGCCGACAAGGAGTTGGTACACATGATCAGCTGGGCCAAGAAGATTCCCGGCTTTGTG
GAGCTCAGCCTGTTCGACCAAGTGCGGCTCTTGGAGAGCTGTTGGATGGAGGTGTTAATG
ATGGGGCTGATGTGGCGCTCAATTGACCACCCCGGCAAGCTCATCTTTGCTCCAGATCTT
GTTCTGGACAGGGATGAGGGGAAATGCGTAGAAGGAATTCTGGAAATCTTTGACATGCTC
CTGGCAACTACTTCAAGGTTTCGAGAGTTAAAACTCCAACACAAAGAATATCTCTGTGTC
AAGGCCATGATCCTGCTCAATTCCAGTATGTACCCTCTGGTCACAGCGACCCAGGATGCT
GACAGCAGCCGGAAGCTGGCTCACTTGCTGAACGCCGTGACCGATGCTTTGGTTTGGGTG
ATTGCCAAGAGCGGCATCTCCTCCCAGCAGCAATCCATGCGCCTGGCTAACCTCCTGATG
CTCCTGTCCCACGTCAGGCATGCGAGTAACAAGGGCATGGAACATCTGCTCAACATGAAG
TGCAAAAATGTGGTCCCAGTGTATGACCTGCTGCTGGAGATGCTGAATGCCCACGTGCTT
CGCGGGTGCAAGTCCTCCATCACGGGGTCCGAGTGCAGCCCGGCAGAGGACAGTAAAAGC
AAAGAGGGCTCCCAGAACCCACAGTCTCAGTGA

# Macromolecular_Interacting_Partner_17_GenBank_ID_Gene:
AB006590

# Macromolecular_Interacting_Partner_17_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_17_Locus:
14q23.2

# Macromolecular_Interacting_Partner_17_SNPs:
rs1256049; rs1541060; rs1256054; rs928554; rs1271572; rs2987983; rs1952586; rs6573553; rs4986938; rs1571512; rs3020445; rs2978381; rs3020450; rs12436302; rs10137185; rs3783736; rs2357479; rs1887994; rs3020444; rs1255998; rs11625778; rs17101774; rs9788441; rs8018687; rs6573552; rs10146107; rs1256120; rs17226046; rs10146464; rs7159462; rs8011682; rs2978382; rs17226060; rs11629158; rs6573554; rs10483774; rs10136822; rs3020447; rs3020446; rs1256027; rs7146908; rs10047818; rs17226088; rs10142856; rs12432174; rs3020443; rs3829768; rs8008187; rs3020449; rs2987976; rs1256029; rs12436533; rs17179740; rs10142766; rs8019025; rs35000350; rs17226081; rs12436325; rs17101765; rs12589834; rs35142532; rs34996860; rs1256033; rs944459; rs1256044; rs1256065; rs1269056; rs1952585; rs944045; rs1256056; rs944460; rs1152577; rs1152579; rs960070; rs1256030; rs1256031; rs1152578; rs1256061; rs1256066; rs867443; rs1256037; rs1256039; rs4365213; rs944050; rs1256036; rs1256059; rs10148269; rs1256048; rs6573549; rs1256043; rs1256063; rs1256064; rs1152580; rs12432029; rs8006145; rs944461; rs8017441; rs8003490; rs1256062; rs960069; rs1256045; rs7154455; rs1256041; rs11844783; rs11850375; rs1256046; rs6573551; rs12435284; rs10144225; rs12435857; rs1256055; rs17225885; rs7151379; rs1760988; rs1256040; rs6573550; rs1152576; rs1256047; rs10143616; rs1109056; rs2274705; rs953592; rs1256038; rs1256032; rs12437103; rs8022377; rs944458; rs12435307; rs1256042; rs8021763; rs10136955; rs17101734; rs944046; rs10143846; rs10459452; rs11621314; rs8020356; rs17766755; rs4991135; rs1152581; rs1273196; rs12435278; rs1256060; rs1256052; rs7157428; rs3742614; rs17101732; rs12436020; rs8003034; rs1256050; rs35743760; rs1256053; rs1271573; rs1256034; rs944047; rs34335763; rs8004907; rs8005720; rs28560770; rs7150504; rs28533821; rs35470913; rs36101201; rs10586023; rs35977223; rs1256122; rs12878151; rs35838376; rs11849012; rs12896657; rs10142387; rs12896460; rs8012102; rs12878171; rs12896656; rs1256028; rs34279976; rs34042570; rs34379325; rs28663685; rs12878317; rs35178946; rs12434123; rs12888944; rs1256121; rs12323665; rs35444147; rs10137994; rs34259492; rs10542764; rs12878448; rs33911435; rs35524660; rs10559131; rs8020953; rs28590754; rs28440970; rs35626954; rs28791544; rs10139423; rs2738411; rs3832949; rs12880680; rs28862689; rs35325527; rs12878147; rs35415214; rs35309509; rs34365161; rs8004284; rs12896484; rs35805395; rs34422347; rs35945666; rs35000680; rs2987980; rs34187403; rs7150300; rs3783734; rs34429939; rs28858114; rs3841304; rs12892242; rs28402888; rs35866794; rs12323439; rs33938319; rs12892235; rs8014219; rs2987975; rs9788467; rs28811117; rs34974677; rs28659912; rs11325384; rs2031960; rs10628372; rs36108515; rs35006597; rs9788542; rs2978380; rs35559445; rs34837234; rs12878447; rs3783735; rs28871406; rs28435160; rs2983748; rs10564800; rs12894175; rs12893594; rs28458963; rs35491543; rs7156924; rs34515626; rs35815260; rs11444056; rs4322568; rs36105498; rs10595890; rs7152484; rs34967796; rs10691382; rs28499370; rs35078414; rs10696080; rs2026086; rs5809224; rs36099966; rs13329021; rs35749298; rs35844028; rs34059608; rs34677580; rs7493519; rs2989401; rs34656479; rs12101211; rs28418648; rs35386350; rs36116809; rs36040036; rs34160122; rs34470395; rs944049; rs11621345; rs28649584; rs7152914; rs36020117; rs4902271; rs34569310; rs11314686; rs10589699; rs1256051; rs12897137; rs7144250; rs5809219; rs2738415; rs5809225; rs34204033; rs1152602; rs34249101; rs867442; rs35340653; rs35650237; rs35350228; rs35261009; rs35044026; rs10629775; rs10557691; rs36098496; rs12894156; rs34433810; rs34478884; rs35412659; rs34972936; rs33977154; rs35308773; rs17101753; rs11851942; rs12883967; rs34136916; rs11441046; rs2776606; rs7159990; rs944048; rs7146434; rs34568139; rs34618726; rs35874406; rs4462498; rs11439683; rs10140457; rs34745821; rs35291917; rs34179608; rs5809222; rs5027281; rs10142498; rs33992698; rs2023141; rs11621342; rs17101742; rs34288779; rs3034336; rs34373341; rs11415529; rs11297817; rs12883941; rs34959266; rs4027300; rs12587432; rs28485225; rs35394904; rs34564792; rs34846309; rs8013331; rs7493535; rs1977487; rs12892916; rs5027282; rs12889431; rs34313437; rs2094914; rs34624204; rs1048312; rs1048315; rs1048350; rs1048357; rs1152582; rs1152583; rs1152584; rs1152585; rs1152588; rs1152589; rs12434245; rs12435338; rs12435395; rs1255997; rs1256112; rs1256114; rs1256116; rs13136; rs17179404; rs2236530; rs2297621; rs2772163; rs34820571; rs35315070; rs35648226; rs35700578; rs35763782; rs35831865; rs7145919; rs7229; rs8020646; rs870404; rs915057; rs9323448; rs941697; rs944051; rs944052

# Macromolecular_Interacting_Partner_17_General_References:
9473491; 9636657; 8769313; 9671811; 9685228; 10964723; 9267036; 9325313; 10681503; 11113208; 12415108

# Macromolecular_Interacting_Partner_17_References:
15181079; 15994348

# Macromolecular_Interacting_Partner_18_ID:
7844

# Macromolecular_Interacting_Partner_18_Name:
Insulin-like growth factor IA precursor

# Macromolecular_Interacting_Partner_18_Synonyms:
IGF-IA; Somatomedin C; Mechano growth factor; MGF

# Macromolecular_Interacting_Partner_18_Gene_Name:
IGF1

# Macromolecular_Interacting_Partner_18_Protein_Sequence:
>Insulinlike growth factor IA precursor
MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD
ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS
VRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM

# Macromolecular_Interacting_Partner_18_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_18_Molecular_Weight:
17026

# Macromolecular_Interacting_Partner_18_Theoretical_pI:
9.40

# Macromolecular_Interacting_Partner_18_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
Function:  neuropeptide hormone activity
Function:  prothoracicotrophic hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_18_General_Function:
Not Available

# Macromolecular_Interacting_Partner_18_Specific_Function:
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity

# Macromolecular_Interacting_Partner_18_Pathway:
Not Available

# Macromolecular_Interacting_Partner_18_Reaction:
Not Available

# Macromolecular_Interacting_Partner_18_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_18_Signals:
1-21

# Macromolecular_Interacting_Partner_18_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_18_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_18_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_18_GenBank_ID_Protein:
183110

# Macromolecular_Interacting_Partner_18_SwissProt_ID:
IGF1A_HUMAN (P01343)

# Macromolecular_Interacting_Partner_18_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_18_Genecard_id:
IGF1

# Macromolecular_Interacting_Partner_18_Geneatlas_id:
IGF1

# Macromolecular_Interacting_Partner_18_hgnc_id:
HGNC:5464

# Macromolecular_Interacting_Partner_18_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_18_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_18_Gene_Sequence:
>462 bp
ATGGGAAAAATCAGCAGTCTTCCAACCCAATTATTTAAGTGCTGCTTTTGTGATTTCTTG
AAGGTGAAGATGCACACCATGTCCTCCTCGCATCTCTTCTACCTGGCGCTGTGCCTGCTC
ACCTTCACCAGCTCTGCCACGGCTGGACCGGAGACGCTCTGCGGGGCTGAGCTGGTGGAT
GCTCTTCAGTTCGTGTGTGGAGACAGGGGCTTTTATTTCAACAAGCCCACAGGGTATGGC
TCCAGCAGTCGGAGGGCGCCTCAGACAGGCATCGTGGATGAGTGCTGCTTCCGGAGCTGT
GATCTAAGGAGGCTGGAGATGTATTGCGCACCCCTCAAGCCTGCCAAGTCAGCTCGCTCT
GTCCGTGCCCAGCGCCACACCGACATGCCCAAGACCCAGAAGGAAGTACATTTGAAGAAC
GCAAGTAGAGGGAGTGCAGGAAACAAGAACTACAGGATGTAG

# Macromolecular_Interacting_Partner_18_GenBank_ID_Gene:
M14156

# Macromolecular_Interacting_Partner_18_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_18_Locus:
12q22-q23

# Macromolecular_Interacting_Partner_18_SNPs:
rs17884626; rs3729846; rs6220; rs6219; rs5742714; rs6214; rs6216; rs5742707; rs6217; rs6222; rs3730192; rs3730205; rs5742711; rs3730204; rs5742705; rs6221; rs5742713; rs5742715; rs3730189; rs5742706; rs1063599; rs6218; rs5742700; rs6215; rs35528193; rs17881987; rs3209674; rs6212; rs3730201; rs3730190; rs5742704; rs1140655; rs17879349; rs5031032; rs978458; rs2373721; rs1019731; rs2195240; rs2288378; rs2195239; rs5742629; rs11111274; rs5742657; rs2033178; rs7314527; rs10860869; rs4764696; rs10778176; rs9989002; rs4764883; rs12310428; rs5009837; rs5742659; rs9308315; rs972936; rs5742683; rs4764886; rs10735380; rs4764887; rs7136446; rs5742632; rs7956547; rs5742692; rs17727519; rs6213; rs17880975; rs17882264; rs10047577; rs2072592; rs17879892; rs5742627; rs5742634; rs6539035; rs10860865; rs5742694; rs17032565; rs5742620; rs5742644; rs12821878; rs11831436; rs7957559; rs5742696; rs10745942; rs17032634; rs5742682; rs1520221; rs17727841; rs11829586; rs1549593; rs2195242; rs10860867; rs9651925; rs17884734; rs17884998; rs5742658; rs4764698; rs11111265; rs5742665; rs11831702; rs12305089; rs12423791; rs5742614; rs5742639; rs5742643; rs5742690; rs17885092; rs12299353; rs2162679; rs5742695; rs5742653; rs5742623; rs17032623; rs5742615; rs11837195; rs11111272; rs5742668; rs5742626; rs5742624; rs5742678; rs5742637; rs11111267; rs1520220; rs7132915; rs5742667; rs5742652; rs5742669; rs5742618; rs10778174; rs4764697; rs28682289; rs5742671; rs11111266; rs4764699; rs5742655; rs5742638; rs10778175; rs5742666; rs5742617; rs5742663; rs12833855; rs5742689; rs5742622; rs17885209; rs7300373; rs5742654; rs5742645; rs7971494; rs5742636; rs10745940; rs17796225; rs5742661; rs35996361; rs17886202; rs5742656; rs5742686; rs5742670; rs2373722; rs35524121; rs17882461; rs11111269; rs35626892; rs11111262; rs5742647; rs10860864; rs17882373; rs5742664; rs12313279; rs17884900; rs5742625; rs17878658; rs7296464; rs17879380; rs12426645; rs5742635; rs5742688; rs5742628; rs6539036; rs5742672; rs34300540; rs5742649; rs4764885; rs35897406; rs35349902; rs35209973; rs5742630; rs17882108; rs17878845; rs17885477; rs1520222; rs17886416; rs17881922; rs35437018; rs17879867; rs12316064; rs5742633; rs34291100; rs34311929; rs5742660; rs5742641; rs17878318; rs5742648; rs17884646; rs11608757; rs5742621; rs5742684; rs12425939; rs4764884; rs10860866; rs17032577; rs17878342; rs35767; rs5742722; rs5742723; rs2946834; rs11829707; rs5742720; rs5742612; rs11829693; rs2288377; rs5742716; rs3730195; rs3730193; rs35365615; rs5742702; rs3730211; rs3730224; rs5742712; rs3730210; rs4479044; rs3730207; rs5800508; rs34632512; rs17884961; rs5742698; rs3730206; rs3730203; rs35306040; rs35234844; rs3730188; rs3730226; rs17885397; rs5742703; rs5742701; rs2114911; rs3730218; rs5742708; rs3730221; rs28399924; rs35770817; rs1142050; rs3730200; rs35042457; rs1063600; rs14970; rs34621369; rs5742709; rs3032446; rs3730209; rs3730191; rs5742613; rs3730223; rs17847185; rs5742710; rs3730212; rs3730208; rs17847188; rs35359199; rs5800507; rs17886337; rs35249557; rs12817059; rs9282710; rs34903472; rs5742693; rs12299690; rs34647656; rs5742675; rs12810139; rs10745941; rs2373723; rs17879585; rs17880891; rs12320356; rs35140968; rs5800510; rs17879693; rs17882696; rs35437431; rs35174508; rs5742687; rs17885230; rs11608743; rs12368271; rs17882221; rs2373724; rs17886520; rs35775928; rs5742619; rs10860863; rs17885564; rs5742676; rs5742677; rs11421600; rs34805296; rs12816379; rs11608742; rs11111273; rs17879010; rs17886798; rs17882149; rs34599859; rs12817072; rs3032454; rs34813772; rs10860868; rs17879390; rs11111268; rs17885210; rs9282711; rs17886237; rs35222135; rs17878871; rs3729847; rs10557735; rs12320358; rs12819048; rs17878637; rs34545292; rs17882016; rs17878716; rs10614489; rs34568432; rs5742650; rs11111279; rs17881804; rs17878620; rs5742616; rs35813377; rs35403470; rs5742640; rs5742673; rs35865277; rs17879664; rs10685119; rs5742680; rs11111263; rs12314338; rs17878397; rs11111271; rs17880004; rs5742681; rs5742646; rs35004383; rs11111278; rs34817710; rs36103805; rs11111270; rs5742651; rs17881582; rs17885105; rs12816545; rs17882697; rs5742674; rs35123842; rs10161018; rs17882126; rs35993329; rs5742697; rs764911; rs11111277; rs35635523; rs12809983; rs5742631; rs1015693; rs17878818; rs12370356; rs11111276; rs35660465; rs7297946; rs11111281; rs11305762; rs34097393; rs34199594; rs5742662; rs17881697; rs36047405; rs36123817; rs4764882; rs17878303; rs36005419; rs17886265; rs17728444; rs12319588; rs17884880; rs34918171; rs11111264; rs35433913; rs5800512; rs17885262; rs17879785; rs17879563; rs17883650; rs34618338; rs34085295; rs34241965; rs17883689; rs34212937; rs17882244; rs17887104; rs34938746; rs35261849; rs12816586; rs17885578; rs17882564; rs17884984; rs17879080; rs17879837; rs12820619; rs11111280; rs12229818; rs17885158; rs5742691; rs34800889; rs12821533; rs11837097; rs5742679; rs17882237; rs12301183; rs34432139; rs17886964; rs34588740; rs5742685; rs10542027; rs35407198; rs5742642; rs17882333; rs10592539; rs5800511; rs17885342; rs35384466; rs3033405; rs12830260; rs2217241; rs3033407; rs17879774; rs35806302; rs17882374; rs5742717; rs10665874; rs5742719; rs5800513; rs7487728; rs5742718; rs17884864; rs5742721; rs10860860; rs10860861; rs10860862; rs11111259; rs11111260; rs11111261; rs11111282; rs11831864; rs12301163; rs12301559; rs12579077; rs12579108; rs1457601; rs17032483; rs17032487; rs17032648; rs2373720; rs2946831; rs2971575; rs2971577; rs35765; rs35766; rs7316439; rs7980083; rs855201; rs9919733

# Macromolecular_Interacting_Partner_18_General_References:
2937782; 6358902; 2935423; 3002851; 2018498; 1372070; 6382022; 632300; 6189745; 2036417; 1319992; 3242681; 8857020

# Macromolecular_Interacting_Partner_18_References:
15021445; 15182293

# Macromolecular_Interacting_Partner_19_ID:
7951

# Macromolecular_Interacting_Partner_19_Name:
Interstitial collagenase precursor

# Macromolecular_Interacting_Partner_19_Synonyms:
Matrix metalloproteinase-1; MMP-1; Fibroblast collagenase[Contains: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase]

# Macromolecular_Interacting_Partner_19_Gene_Name:
MMP1

# Macromolecular_Interacting_Partner_19_Protein_Sequence:
>Interstitial collagenase precursor
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN

# Macromolecular_Interacting_Partner_19_Number_of_Residues:
469

# Macromolecular_Interacting_Partner_19_Molecular_Weight:
54007

# Macromolecular_Interacting_Partner_19_Theoretical_pI:
6.97

# Macromolecular_Interacting_Partner_19_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  metallopeptidase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  metalloendopeptidase activity
 ||
>>>
Process:  carbohydrate metabolism
Process:  cellular carbohydrate metabolism
Process:  peptidoglycan metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  extracellular matrix
Component:  extracellular matrix (sensu Metazoa)

# Macromolecular_Interacting_Partner_19_General_Function:
Not Available

# Macromolecular_Interacting_Partner_19_Specific_Function:
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity

# Macromolecular_Interacting_Partner_19_Pathway:
Not Available

# Macromolecular_Interacting_Partner_19_Reaction:
Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-|-Ile in the alpha1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue

# Macromolecular_Interacting_Partner_19_Pfam_Domain_Function:
PF00045:Hemopexin;
PF00413:Peptidase_M10;
PF01471:PG_binding_1

# Macromolecular_Interacting_Partner_19_Signals:
1-19

# Macromolecular_Interacting_Partner_19_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_19_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_19_EC_Link:
EC 3.4.24.7

# Macromolecular_Interacting_Partner_19_GenBank_ID_Protein:
30126

# Macromolecular_Interacting_Partner_19_SwissProt_ID:
MMP1_HUMAN (P03956)

# Macromolecular_Interacting_Partner_19_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_19_Genecard_id:
MMP1

# Macromolecular_Interacting_Partner_19_Geneatlas_id:
MMP1

# Macromolecular_Interacting_Partner_19_hgnc_id:
HGNC:7155

# Macromolecular_Interacting_Partner_19_PDB_ID:
1SU3

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_19_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_19_Gene_Sequence:
>1410 bp
ATGCACAGCTTTCCTCCACTGCTGCTGCTGCTGTTCTGGGGTGTGGTGTCTCACAGCTTC
CCAGCGACTCTAGAAACACAAGAGCAAGATGTGGACTTAGTCCAGAAATACCTGGAAAAA
TACTACAACCTGAAGAATGATGGGAGGCAAGTTGAAAAGCGGAGAAATAGTGGCCCAGTG
GTTGAAAAATTGAAGCAAATGCAGGAATTCTTTGGGCTGAAAGTGACTGGGAAACCAGAT
GCTGAAACCCTGAAGGTGATGAAGCAGCCCAGATGTGGAGTGCCTGATGTGGCTCAGTTT
GTCCTCACTGAGGGGAACCCTCGCTGGGAGCAAACACATCTGACCTACAGGATTGAAAAT
TACACGCCAGATTTGCCAAGAGCAGATGTGGACCATGCCATTGAGAAAGCCTTCCAACTC
TGGAGTAATGTCACACCTCTGACATTCACCAAGGTCTCTGAGGGTCAAGCAGACATCATG
ATATCTTTTGTCAGGGGAGATCATCGGGACAACTCTCCTTTTGATGGACCTGGAGGAAAT
CTTGCTCATGCTTTTCAACCAGGCCCAGGTATTGGAGGGGATGCTCATTTTGATGAAGAT
GAAAGGTGGACCAACAATTTCAGAGAGTACAACTTACATCGTGTTGCGGCTCATGAACTC
GGCCATTCTCTTGGACTCTCCCATTCTACTGATATCGGGGCTTTGATGTACCCTAGCTAC
ACCTTCAGTGGTGATGTTCAGCTAGCTCAGGATGACATTGATGGCATCCAAGCCATATAT
GGACGTTCCCAAAATCCTGTCCAGCCCATCGGCCCACAAACCCCAAAAGCATGTGACAGT
AAGCTAACCTTTGATGCTATAACTACGATTCGGGGAGAAGTGATGTTCTTTAAAGACAGA
TTCTACATGCGCACAAATCCCTTCTACCCGGAAGTTGAGCTCAATTTCATTTCTGTTTTC
TGGCCACAACTGCCAAATGGGCTTGAAGCTGCTTACGAATTTGCCGACAGAGATGAAGTC
CGGTTTTTCAAAGGGAATAAGTACTGGGCTGTTCAGGGACAGAATGTGCTACACGGATAC
CCCAAGGACATCTACAGCTCCTTTGGCTTCCCTAGAACTGTGAAGCATATCGATGCTGCT
CTTTCTGAGGAAAACACTGGAAAAACCTACTTCTTTGTTGCTAACAAATACTGGAGGTAT
GATGAATATAAACGATCTATGGATCCAGGTTATCCCAAAATGATAGCACATGACTTTCCT
GGAATTGGCCACAAAGTTGATGCAGTTTTCATGAAAGATGGATTTTTCTATTTCTTTCAT
GGAACAAGACAATACAAATTTGATCCTAAAACGAAGAGAATTTTGACTCTCCAGAAAGCT
AATAGCTGGTTCAACTGCAGGAAAAATTGA

# Macromolecular_Interacting_Partner_19_GenBank_ID_Gene:
X54925

# Macromolecular_Interacting_Partner_19_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_19_Locus:
11q22.3

# Macromolecular_Interacting_Partner_19_SNPs:
rs17879749; rs513964; rs1051121; rs470558; rs10488; rs2071230; rs470215; rs5854; rs2239008; rs3213460; rs5031038; rs470747; rs470132; rs7125062; rs2071231; rs7125320; rs488178; rs17880344; rs491152; rs17883114; rs5031036; rs17884145; rs17879960; rs996999; rs17881028; rs657043; rs17879947; rs470358; rs11225426; rs12417847; rs1938901; rs17883832; rs17882844; rs17881127; rs2071232; rs11225425; rs41372749; rs17878931; rs470221; rs17882679; rs17885950; rs17885595; rs17881293; rs17878905; rs1144391; rs17884110; rs17885441; rs1144393; rs475007; rs498186; rs17882592; rs11600510; rs17293823; rs494379; rs17293761; rs473509; rs11604098; rs514921; rs7945189; rs2075847; rs17885563; rs17883787; rs17883958; rs470504; rs17885361; rs1799750; rs17884166; rs17884081; rs17880243; rs17884522; rs17884329; rs11557268; rs17879973; rs554499; rs7124068; rs17884120; rs17879165; rs12282811; rs17883091; rs17880115; rs17880320; rs11225424; rs17883374; rs17881394; rs17880645; rs17883104; rs17883560; rs17880109; rs17883332; rs17882811; rs12272274; rs35308410; rs17883892; rs553800; rs34766388; rs11225423; rs11365927; rs41500345; rs17884181; rs41524845; rs33979725; rs12276217; rs5031035; rs17883326; rs7951192; rs17880516; rs35066753; rs17883075; rs17882870; rs5794198; rs12274737; rs17880535; rs5031037; rs17883905; rs11390663; rs470211; rs17880681; rs17099570; rs11292517; rs36008532; rs17886083; rs17879920; rs17885504; rs7108193; rs17879793; rs17880553; rs3180523; rs470146; rs11225421; rs11225422; rs1155764; rs12274582; rs12283571; rs17293642; rs17435959; rs17860942; rs1938894; rs1938898; rs1938899; rs1939008; rs2105581; rs2408489; rs2408490; rs2839969; rs34686002; rs470130; rs470206; rs470226; rs4754880; rs484915; rs504875; rs509332; rs519806; rs521898; rs533621; rs534191; rs559518; rs573764; rs574939; rs575727; rs576979; rs610778; rs610821; rs685265; rs7107224; rs7112080; rs7125865; rs7127735

# Macromolecular_Interacting_Partner_19_General_References:
2167156; 3030290; 3009463; 3037355; 3027129; 2557822; 3032950; 7656013; 8031754; 8278810; 8090713; 9484219

# Macromolecular_Interacting_Partner_19_References:
12880581; 15675949; 16297642

# Macromolecular_Interacting_Partner_20_ID:
8442

# Macromolecular_Interacting_Partner_20_Name:
Tumor necrosis factor receptor superfamily member 1A precursor

# Macromolecular_Interacting_Partner_20_Synonyms:
p60; TNF-R1; TNF-RI; TNFR-I; p55; CD120a antigen[Contains: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1; TBPI]

# Macromolecular_Interacting_Partner_20_Gene_Name:
TNFRSF1A

# Macromolecular_Interacting_Partner_20_Protein_Sequence:
>Tumor necrosis factor receptor superfamily member 1A precursor
MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCT
KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVD
RDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECV
SCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWK
SKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYT
PGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLY
AVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLEL
LGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR

# Macromolecular_Interacting_Partner_20_Number_of_Residues:
455

# Macromolecular_Interacting_Partner_20_Molecular_Weight:
50495

# Macromolecular_Interacting_Partner_20_Theoretical_pI:
6.62

# Macromolecular_Interacting_Partner_20_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  binding
Function:  protein binding
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_20_General_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Specific_Function:
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase

# Macromolecular_Interacting_Partner_20_Pathway:
Not Available

# Macromolecular_Interacting_Partner_20_Reaction:
Not Available

# Macromolecular_Interacting_Partner_20_Pfam_Domain_Function:
PF00531:Death;
PF00020:TNFR_c6

# Macromolecular_Interacting_Partner_20_Signals:
1-21

# Macromolecular_Interacting_Partner_20_Transmembrane_Regions:
212-234

# Macromolecular_Interacting_Partner_20_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_20_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_20_GenBank_ID_Protein:
37224

# Macromolecular_Interacting_Partner_20_SwissProt_ID:
TNR1A_HUMAN (P19438)

# Macromolecular_Interacting_Partner_20_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_20_Genecard_id:
TNFRSF1A

# Macromolecular_Interacting_Partner_20_Geneatlas_id:
TNFRSF1A

# Macromolecular_Interacting_Partner_20_hgnc_id:
HGNC:11916

# Macromolecular_Interacting_Partner_20_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_20_Subcellular_Location:
Cell membrane; single-pass type I membrane protein. Secreted protein

# Macromolecular_Interacting_Partner_20_Gene_Sequence:
>1368 bp
ATGGGCCTCTCCACCGTGCCTGACCTGCTGCTGCCGCTGGTGCTCCTGGAGCTGTTGGTG
GGAATATACCCCTCAGGGGTTATTGGACTGGTCCCTCACCTAGGGGACAGGGAGAAGAGA
GATAGTGTGTGTCCCCAAGGAAAATATATCCACCCTCAAAATAATTCGATTTGCTGTACC
AAGTGCCACAAAGGAACCTACTTGTACAATGACTGTCCAGGCCCGGGGCAGGATACGGAC
TGCAGGGAGTGTGAGAGCGGCTCCTTCACCGCTTCAGAAAACCACCTCAGACACTGCCTC
AGCTGCTCCAAATGCCGAAAGGAAATGGGTCAGGTGGAGATCTCTTCTTGCACAGTGGAC
CGGGACACCGTGTGTGGCTGCAGGAAGAACCAGTACCGGCATTATTGGAGTGAAAACCTT
TTCCAGTGCTTCAATTGCAGCCTCTGCCTCAATGGGACCGTGCACCTCTCCTGCCAGGAG
AAACAGAACACCGTGTGCACCTGCCATGCAGGTTTCTTTCTAAGAGAAAACGAGTGTGTC
TCCTGTAGTAACTGTAAGAAAAGCCTGGAGTGCACGAAGTTGTGCCTACCCCAGATTGAG
AATGTTAAGGGCACTGAGGACTCAGGCACCACAGTGCTGTTGCCCCTGGTCATTTTCTTT
GGTCTTTGCCTTTTATCCCTCCTCTTCATTGGTTTAATGTATCGCTACCAACGGTGGAAG
TCCAAGCTCTACTCCATTGTTTGTGGGAAATCGACACCTGAAAAAGAGGGGGAGCTTGAA
GGAACTACTACTAAGCCCCTGGCCCCAAACCCAAGCTTCAGTCCCACTCCAGGCTTCACC
CCCACCCTGGGCTTCAGTCCCGTGCCCAGTTCCACCTTCACCTCCAGCTCCACCTATACC
CCCGGTGACTGTCCCAACTTTGCGGCTCCCCGCAGAGAGGTGGCACCACCCTATCAGGGG
GCTGACCCCATCCTTGCGACAGCCCTCGCCTCCGACCCCATCCCCAACCCCCTTCAGAAG
TGGGAGGACAGCGCCCACAAGCCACAGAGCCTAGACACTGATGACCCCGCGACGCTGTAC
GCCGTGGTGGAGAACGTGCCCCCGTTGCGCTGGAAGGAATTCGTGCGGCGCCTAGGGCTG
AGCGACCACGAGATCGATCGGCTGGAGCTGCAGAACGGGCGCTGCCTGCGCGAGGCGCAA
TACAGCATGCTGGCGACCTGGAGGCGGCGCACGCCGCGGCGCGAGGCCACGCTGGAGCTG
CTGGGACGCGTGCTCCGCGACATGGACCTGCTGGGCTGCCTGGAGGACATCGAGGAGGCG
CTTTGCGGCCCCGCCGCCCTCCCGCCCGCGCCCAGTCTTCTCAGATGA

# Macromolecular_Interacting_Partner_20_GenBank_ID_Gene:
X55313

# Macromolecular_Interacting_Partner_20_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_20_Locus:
12p13.2

# Macromolecular_Interacting_Partner_20_SNPs:
rs4149637; rs4149584; rs767455; rs1800692; rs1860545; rs4149576; rs4149628; rs4149579; rs4149580; rs4149575; rs1800693; rs4149585; rs4149641; rs877249; rs4149630; rs4149623; rs4149581; rs4149639; rs4149645; rs4149578; rs887477; rs4149583; rs4149629; rs4149587; rs2284344; rs4149577; rs4149640; rs4149643; rs4149638; rs4149633; rs12832171; rs10774425; rs34567207; rs4149574; rs4149644; rs11525582; rs4149586; rs35423438; rs4149631; rs4149573; rs12426675; rs4149622; rs35934465; rs4149572; rs4149642; rs4149626; rs4149569; rs4149618; rs4149621; rs4149570; rs4149617; rs4149619; rs4149620; rs34084986; rs34802704; rs16932194; rs16932532; rs2234649; rs34374789; rs34751757; rs1804532; rs1062460; rs3202413; rs34145452; rs4149636; rs35628847; rs35892050; rs28667612; rs4149625; rs28456232; rs11836766; rs35943076; rs12317730; rs4149624; rs35344531; rs41309816; rs4149627; rs34819705; rs2363888; rs34811673; rs4149634; rs11064142; rs11344522; rs34436408; rs4441073; rs4149582; rs34324660; rs4149632; rs4149635; rs17847989; rs10849443; rs4149571; rs34387311; rs11615387; rs36205633; rs17847987; rs36205629; rs35305386; rs36205627; rs36205945; rs11608320; rs11608322; rs12304937; rs2228576; rs2302350; rs34003829; rs36100233; rs3741913; rs3764873; rs3764874; rs3764875; rs3782719; rs3782720; rs4149646; rs4764497; rs7297961; rs740841

# Macromolecular_Interacting_Partner_20_General_References:
2158863; 2158862; 1698610; 1702293; 2170974; 1315717; 2153136; 9557650; 10359574; 9915703; 8387891; 8939750; 10199409; 11443543; 13130484

# Macromolecular_Interacting_Partner_20_References:
14501948; 15498030

# Macromolecular_Interacting_Partner_21_ID:
8434

# Macromolecular_Interacting_Partner_21_Name:
Interleukin-10 precursor

# Macromolecular_Interacting_Partner_21_Synonyms:
IL-10; Cytokine synthesis inhibitory factor; CSIF

# Macromolecular_Interacting_Partner_21_Gene_Name:
IL10

# Macromolecular_Interacting_Partner_21_Protein_Sequence:
>Interleukin10 precursor
MHSSALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQ
LDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLR
LRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN

# Macromolecular_Interacting_Partner_21_Number_of_Residues:
178

# Macromolecular_Interacting_Partner_21_Molecular_Weight:
20517

# Macromolecular_Interacting_Partner_21_Theoretical_pI:
8.12

# Macromolecular_Interacting_Partner_21_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_21_General_Function:
Not Available

# Macromolecular_Interacting_Partner_21_Specific_Function:
Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells

# Macromolecular_Interacting_Partner_21_Pathway:
Not Available

# Macromolecular_Interacting_Partner_21_Reaction:
Not Available

# Macromolecular_Interacting_Partner_21_Pfam_Domain_Function:
PF00726:IL10

# Macromolecular_Interacting_Partner_21_Signals:
1-18

# Macromolecular_Interacting_Partner_21_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_21_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_21_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_21_GenBank_ID_Protein:
186271

# Macromolecular_Interacting_Partner_21_SwissProt_ID:
IL10_HUMAN (P22301)

# Macromolecular_Interacting_Partner_21_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_21_Genecard_id:
IL10

# Macromolecular_Interacting_Partner_21_Geneatlas_id:
IL10

# Macromolecular_Interacting_Partner_21_hgnc_id:
HGNC:5962

# Macromolecular_Interacting_Partner_21_PDB_ID:
2ILK

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_21_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_21_Gene_Sequence:
>537 bp
ATGCACAGCTCAGCACTGCTCTGTTGCCTGGTCCTCCTGACTGGGGTGAGGGCCAGCCCA
GGCCAGGGCACCCAGTCTGAGAACAGCTGCACCCACTTCCCAGGCAACCTGCCTAACATG
CTTCGAGATCTCCGAGATGCCTTCAGCAGAGTGAAGACTTTCTTTCAAATGAAGGATCAG
CTGGACAACTTGTTGTTAAAGGAGTCCTTGCTGGAGGACTTTAAGGGTTACCTGGGTTGC
CAAGCCTTGTCTGAGATGATCCAGTTTTACCTGGAGGAGGTGATGCCCCAAGCTGAGAAC
CAAGACCCAGACATCAAGGCGCATGTGAACTCCCTGGGGGAGAACCTGAAGACCCTCAGG
CTGAGGCTACGGCGCTGTCATCGATTTCTTCCCTGTGAAAACAAGAGCAAGGCCGTGGAG
CAGGTGAAGAATGCCTTTAATAAGCTCCAAGAGAAAGGCATCTACAAAGCCATGAGTGAG
TTTGACATCTTCATCAACTACATAGAAGCCTACATGACAATGAAGATACGAAACTGA

# Macromolecular_Interacting_Partner_21_GenBank_ID_Gene:
M57627

# Macromolecular_Interacting_Partner_21_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_21_Locus:
1q31-q32

# Macromolecular_Interacting_Partner_21_SNPs:
rs3024496; rs3024498; rs6697497; rs3024510; rs3024497; rs9282739; rs6687786; rs5743628; rs3024499; rs2222202; rs1554286; rs1878672; rs1518111; rs3024490; rs3024492; rs3024508; rs1518110; rs3021094; rs3790622; rs3024491; rs3024509; rs3024493; rs3024494; rs5743627; rs3024495; rs3021093; rs3024507; rs3024500; rs3024505; rs1800872; rs3024489; rs1800893; rs1800896; rs1800871; rs3024502; rs1800894; rs3024503; rs3024501; rs5743623; rs3024488; rs5743624; rs5743626; rs41432052; rs5743629; rs34987208; rs34162991; rs41362744; rs9282740; rs3021098; rs3024506; rs2352792; rs5743631; rs3980910; rs3001099; rs4492619; rs3813960; rs5743632; rs5743625; rs3024504; rs12047368; rs36213837; rs5780362; rs41275354; rs10679268; rs41275352; rs34038587; rs10494879; rs11119474; rs12027844; rs12028710; rs12029006; rs12029597; rs12758116; rs13376708; rs1800890; rs1800892; rs1800895; rs3001102; rs3001103; rs4390174; rs4844553; rs6673928; rs6686931; rs7512090; rs7548373

# Macromolecular_Interacting_Partner_21_General_References:
1847510; 9405662; 8364028; 7547951; 8590020; 8897595; 12825869

# Macromolecular_Interacting_Partner_21_References:
12692147; 14501948; 15547086

# Macromolecular_Interacting_Partner_22_ID:
8081

# Macromolecular_Interacting_Partner_22_Name:
Leptin precursor

# Macromolecular_Interacting_Partner_22_Synonyms:
Obesity factor; Obese protein

# Macromolecular_Interacting_Partner_22_Gene_Name:
LEP

# Macromolecular_Interacting_Partner_22_Protein_Sequence:
>Leptin precursor
MHWGTLCGFLWLWPYLFYVQAVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGL
DFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLP
WASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC

# Macromolecular_Interacting_Partner_22_Number_of_Residues:
167

# Macromolecular_Interacting_Partner_22_Molecular_Weight:
18641

# Macromolecular_Interacting_Partner_22_Theoretical_pI:
6.34

# Macromolecular_Interacting_Partner_22_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_22_General_Function:
Not Available

# Macromolecular_Interacting_Partner_22_Specific_Function:
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass

# Macromolecular_Interacting_Partner_22_Pathway:
Not Available

# Macromolecular_Interacting_Partner_22_Reaction:
Not Available

# Macromolecular_Interacting_Partner_22_Pfam_Domain_Function:
PF02024:Leptin

# Macromolecular_Interacting_Partner_22_Signals:
1-21

# Macromolecular_Interacting_Partner_22_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_22_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_22_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_22_GenBank_ID_Protein:
623332

# Macromolecular_Interacting_Partner_22_SwissProt_ID:
LEP_HUMAN (P41159)

# Macromolecular_Interacting_Partner_22_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_22_Genecard_id:
LEP

# Macromolecular_Interacting_Partner_22_Geneatlas_id:
LEP

# Macromolecular_Interacting_Partner_22_hgnc_id:
HGNC:6553

# Macromolecular_Interacting_Partner_22_PDB_ID:
1AX8

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_22_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_22_Gene_Sequence:
>504 bp
ATGCATTGGGGAACCCTGTGCGGATTCTTGTGGCTTTGGCCCTATCTTTTCTATGTCCAA
GCTGTGCCCATCCAAAAAGTCCAAGATGACACCAAAACCCTCATCAAGACAATTGTCACC
AGGATCAATGACATTTCACACACGCAGTCAGTCTCCTCCAAACAGAAAGTCACCGGTTTG
GACTTCATTCCTGGGCTCCACCCCATCCTGACCTTATCCAAGATGGACCAGACACTGGCA
GTCTACCAACAGATCCTCACCAGTATGCCTTCCAGAAACGTGATCCAAATATCCAACGAC
CTGGAGAACCTCCGGGATCTTCTTCACGTGCTGGCCTTCTCTAAGAGCTGCCACTTGCCC
TGGGCCAGTGGCCTGGAGACCTTGGACAGCCTGGGGGGTGTCCTGGAAGCTTCAGGCTAC
TCCACAGAGGTGGTGGCCCTGAGCAGGCTGCAGGGGTCTCTGCAGGACATGCTGTGGCAG
CTGGACCTCAGCCCTGGGTGCTGA

# Macromolecular_Interacting_Partner_22_GenBank_ID_Gene:
U18915

# Macromolecular_Interacting_Partner_22_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_22_Locus:
7q31.3

# Macromolecular_Interacting_Partner_22_SNPs:
rs17151919; rs13306517; rs28954113; rs11763517; rs4731426; rs10954173; rs11761556; rs4731427; rs2167270; rs7791621; rs10257175; rs12706832; rs11760956; rs7795794; rs28954116; rs11978419; rs10244329; rs17151922; rs2278814; rs28959471; rs10954174; rs4236625; rs7796202; rs28954117; rs28959470; rs28954095; rs28954101; rs28954086; rs28954099; rs28959468; rs3750034; rs28954093; rs2278815; rs2122627; rs28954379; rs28959474; rs28954082; rs41457646; rs28954114; rs28954096; rs28959476; rs28954084; rs28954102; rs28954100; rs2060713; rs28954090; rs28954098; rs28954105; rs28954118; rs11980266; rs28954091; rs12706831; rs28959475; rs28954094; rs28954083; rs28756049; rs11973652; rs3793162; rs17151913; rs17151914; rs6956510; rs2071045; rs3828942; rs7788818; rs10264361; rs28954109; rs28954110; rs28954108; rs28954111; rs791616; rs28954376; rs28954081; rs6976701; rs10262600; rs28954369; rs28954080; rs28954371; rs34104384; rs4728096; rs791620; rs28954372; rs28954373; rs28954375; rs35048003; rs28959478; rs10258300; rs12536535; rs28954378; rs13228377; rs1800564; rs1800583; rs28954097; rs11380467; rs35394014; rs28959469; rs10676401; rs28954106; rs1031340; rs28954115; rs1349398; rs34219283; rs28959472; rs28954088; rs10243710; rs6966536; rs28954104; rs10620014; rs34457895; rs13306516; rs33910507; rs28954107; rs41526944; rs41434248; rs28954087; rs34728887; rs28954103; rs28959473; rs41528456; rs17617757; rs28954089; rs28954092; rs34052732; rs10277407; rs28954112; rs41474844; rs13306518; rs35447711; rs34046133; rs36212573; rs28959477; rs36219262; rs791618; rs28954370; rs791619; rs34669250; rs10598051; rs28954377; rs36219261; rs28391558; rs791617; rs28954374; rs36219260; rs10249476; rs10264838; rs10276311; rs10487506; rs10954175; rs10954176; rs11770725; rs12535708; rs12535747; rs12537573; rs13245201; rs1349419; rs1376268; rs16871960; rs17151895; rs2060715; rs2167271; rs35854831; rs4731423; rs4731424; rs4731428; rs4731429; rs4731430; rs6949498; rs712722; rs7778154; rs7782257; rs7798338; rs7799039; rs7801674; rs7802530; rs791604; rs791606; rs791607; rs791608; rs791610; rs791611; rs791612; rs791613; rs791614; rs791615

# Macromolecular_Interacting_Partner_22_General_References:
7984236; 7789654; 8626726; 7499240; 8621021; 10428856; 9166907; 9144295; 9500540

# Macromolecular_Interacting_Partner_22_References:
12374466; 12488352; 12505887; 12688162

# Macromolecular_Interacting_Partner_23_ID:
8452

# Macromolecular_Interacting_Partner_23_Name:
Lymphotoxin-beta

# Macromolecular_Interacting_Partner_23_Synonyms:
LT-beta; Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3

# Macromolecular_Interacting_Partner_23_Gene_Name:
LTB

# Macromolecular_Interacting_Partner_23_Protein_Sequence:
>Lymphotoxinbeta
MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD
PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS
DAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLE
GAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGA
VMVG

# Macromolecular_Interacting_Partner_23_Number_of_Residues:
244

# Macromolecular_Interacting_Partner_23_Molecular_Weight:
25390

# Macromolecular_Interacting_Partner_23_Theoretical_pI:
5.02

# Macromolecular_Interacting_Partner_23_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_23_General_Function:
Not Available

# Macromolecular_Interacting_Partner_23_Specific_Function:
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional

# Macromolecular_Interacting_Partner_23_Pathway:
Not Available

# Macromolecular_Interacting_Partner_23_Reaction:
Not Available

# Macromolecular_Interacting_Partner_23_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_23_Signals:
1-35

# Macromolecular_Interacting_Partner_23_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_23_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_23_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_23_GenBank_ID_Protein:
292279

# Macromolecular_Interacting_Partner_23_SwissProt_ID:
TNFC_HUMAN (Q06643)

# Macromolecular_Interacting_Partner_23_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_23_Genecard_id:
LTB

# Macromolecular_Interacting_Partner_23_Geneatlas_id:
LTB

# Macromolecular_Interacting_Partner_23_hgnc_id:
HGNC:6711

# Macromolecular_Interacting_Partner_23_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_23_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_23_Gene_Sequence:
>735 bp
ATGGGGGCACTGGGGCTGGAGGGCAGGGGTGGGAGGCTCCAGGGGAGGGGTTCCCTCCTG
CTAGCTGTGGCAGGAGCCACTTCTCTGGTGACCTTGTTGCTGGCGGTGCCTATCACTGTC
CTGGCTGTGCTGGCCTTAGTGCCCCAGGATCAGGGAGGACTGGTAACGGAGACGGCCGAC
CCCGGGGCACAGGCCCAGCAAGGACTGGGGTTTCAGAAGCTGCCAGAGGAGGAGCCAGAA
ACAGATCTCAGCCCCGGGCTCCCAGCTGCCCACCTCATAGGCGCTCCGCTGAAGGGGCAG
GGGCTAGGCTGGGAGACGACGAAGGAACAGGCGTTTCTGACGAGCGGGACGCAGTTCTCG
GACGCCGAGGGGCTGGCGCTCCCGCAGGACGGCCTCTATTACCTCTACTGTCTCGTCGGC
TACCGGGGCCGGGCGCCCCCTGGCGGCGGGGACCCCCAGGGCCGCTCGGTCACGCTGCGC
AGCTCTCTGTACCGGGCGGGGGGCGCCTACGGGCCGGGCACTCCCGAGCTGCTGCTCGAG
GGCGCCGAGACGGTGACTCCAGTGCTGGACCCGGCCAGGAGACAAGGGTACGGGCCTCTC
TGGTACACGAGCGTGGGGTTCGGCGGCCTGGTGCAGCTCCGGAGGGGCGAGAGGGTGTAC
GTCAACATCAGTCACCCCGATATGGTGGACTTCGCGAGAGGGAAGACCTTCTTTGGGGCC
GTGATGGTGGGGTGA

# Macromolecular_Interacting_Partner_23_GenBank_ID_Gene:
L11016

# Macromolecular_Interacting_Partner_23_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_23_Locus:
6p21.3

# Macromolecular_Interacting_Partner_23_SNPs:
Not Available

# Macromolecular_Interacting_Partner_23_General_References:
7916655; 9299492; 10202016

# Macromolecular_Interacting_Partner_23_References:
12597454; 12692147; 14501948; 15240630

# Macromolecular_Interacting_Partner_24_ID:
8202

# Macromolecular_Interacting_Partner_24_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_24_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_24_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_24_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_24_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_24_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_24_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_24_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_24_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_24_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_24_Pathway:
Not Available

# Macromolecular_Interacting_Partner_24_Reaction:
Not Available

# Macromolecular_Interacting_Partner_24_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_24_Signals:
None

# Macromolecular_Interacting_Partner_24_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_24_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_24_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_24_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_24_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_24_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_24_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_24_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_24_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_24_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_24_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_24_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_24_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_24_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_24_Locus:
10q22

# Macromolecular_Interacting_Partner_24_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_24_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_24_References:
14600408; 15657092; 15675949; 15979306

# Macromolecular_Interacting_Partner_25_ID:
7989

# Macromolecular_Interacting_Partner_25_Name:
Orphan nuclear receptor NR1I3

# Macromolecular_Interacting_Partner_25_Synonyms:
Constitutive androstane receptor; CAR; Constitutive activator of retinoid response; Constitutive active response; Orphan nuclear receptor MB67

# Macromolecular_Interacting_Partner_25_Gene_Name:
NR1I3

# Macromolecular_Interacting_Partner_25_Protein_Sequence:
>Orphan nuclear receptor NR1I3
MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQR
RHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGA
HTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLP
VFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQV
EFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYI
KGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS

# Macromolecular_Interacting_Partner_25_Number_of_Residues:
352

# Macromolecular_Interacting_Partner_25_Molecular_Weight:
39943

# Macromolecular_Interacting_Partner_25_Theoretical_pI:
8.26

# Macromolecular_Interacting_Partner_25_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_25_General_Function:
Not Available

# Macromolecular_Interacting_Partner_25_Specific_Function:
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element

# Macromolecular_Interacting_Partner_25_Pathway:
Not Available

# Macromolecular_Interacting_Partner_25_Reaction:
Not Available

# Macromolecular_Interacting_Partner_25_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_25_Signals:
None

# Macromolecular_Interacting_Partner_25_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_25_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_25_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_25_GenBank_ID_Protein:
458542

# Macromolecular_Interacting_Partner_25_SwissProt_ID:
NR1I3_HUMAN (Q14994)

# Macromolecular_Interacting_Partner_25_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_25_Genecard_id:
NR1I3

# Macromolecular_Interacting_Partner_25_Geneatlas_id:
NR1I3

# Macromolecular_Interacting_Partner_25_hgnc_id:
HGNC:7969

# Macromolecular_Interacting_Partner_25_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_25_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_25_Gene_Sequence:
>1047 bp
ATGGCCAGTAGGGAAGATGAGCTGAGGAACTGTGTGGTATGTGGGGACCAAGCCACAGGC
TACCACTTTAATGCGCTGACTTGTGAGGGCTGCAAGGGTTTCTTCAGGAGAACAGTCAGC
AAAAGCATTGGTCCCACCTGCCCCTTTGCTGGAAGCTGTGAAGTCAGCAAGACTCAGAGG
CGCCACTGCCCAGCCTGCAGGTTGCAGAAGTGCTTAGATGCTGGCATGAGGAAAGACATG
ATACTGTCGGCAGAAGCCCTGGCATTGCGGCGAGCAAAGCAGGCCCAGCGGCGGGCACAG
CAAACACCTGTGCAACTGAGTAAGGAGCAAGAAGAGCTGATCCGGACACTCCTGGGGGCC
CACACCCGCCACATGGGCACCATGTTTGAACAGTTTGTGCAGTTTAGGCCTCCAGCTCAT
CTGTTCATCCATCACCAGCCCTTGCCCACCCTGGCCCCTGTGCTGCCTCTGGTCACACAC
TTCGCAGACATCAACACTTTCATGGTACTGCAAGTCATCAAGTTTACTAAGGACCTGCCC
GTCTTCCGTTCCCTGCCCATTGAAGACCAGATCTCCCTTCTCAAGGGAGCAGCTGTGGAA
ATCTGTCACATCGTACTCAATACCACTTTCTGTCTCCAAACACAAAACTTCCTCTGCGGG
CCTCTTCGCTACACAATTGAAGATGGAGCCCGTGTGGGGTTCCAGGTAGAGTTTTTGGAG
TTGCTCTTTCACTTCCATGGAACACTACGAAAACTGCAGCTCCAAGAGCCTGAGTATGTG
CTCTTGGCTGCCATGGCCCTCTTCTCTCCTGACCGACCTGGAGTTACCCAGAGAGATGAG
ATTGATCAGCTGCAAGAGGAGATGGCACTGACTCTGCAAAGCTACATCAAGGGCCAGCAG
CGAAGGCCCCGGGATCGGTTTCTGTATGCGAAGTTGCTAGGCCTGCTGGCTGAGCTCCGG
AGCATTAATGAGGCCTACGGGTACCAAATCCAGCACATCCAGGGCCTGTCTGCCATGATG
CCGCTGCTCCAGGAGATCTGCAGCTGA

# Macromolecular_Interacting_Partner_25_GenBank_ID_Gene:
Z30425

# Macromolecular_Interacting_Partner_25_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_25_Locus:
1q23.3

# Macromolecular_Interacting_Partner_25_SNPs:
rs2307424; rs2307415; rs2307426; rs3003596; rs6686001; rs2501873; rs2502815; rs3003594; rs2501874; rs3123553; rs2307420; rs9725457; rs7527212; rs2501872; rs12122674; rs11265569; rs2502814; rs12402656; rs11265567; rs11578161; rs11265568; rs2307422; rs2502805; rs11584878; rs10797095; rs2502804; rs41270857; rs1140627; rs2307425; rs35446005; rs11265570; rs10629312; rs10538494; rs4465228; rs28753377; rs12027348; rs28435404; rs7414014; rs28413597; rs12120502; rs11578173; rs28738963; rs28673490; rs28698300; rs28602605; rs12027568; rs35513458; rs34795024; rs34248246; rs28689882; rs10157822; rs11265571; rs11265572; rs11584174; rs12028056; rs12029543; rs12041273; rs12143639; rs12144333; rs12562860; rs12565545; rs12721033; rs12721034; rs12721035; rs12824; rs13306172; rs1803089; rs1803091; rs2307414; rs2307416; rs2307417; rs2307418; rs2307419; rs2307421; rs2501870; rs2502802; rs2502807; rs36017137; rs3813625; rs3813627; rs3813628; rs3813629; rs3829793; rs4073054; rs4233368; rs4489574; rs4656996; rs5082; rs5083; rs5084; rs5087; rs5088; rs6413452; rs6413453; rs7528588; rs7530560

# Macromolecular_Interacting_Partner_25_General_References:
8114692; 8603043

# Macromolecular_Interacting_Partner_25_References:
12482595

# Macromolecular_Interacting_Partner_26_ID:
8013

# Macromolecular_Interacting_Partner_26_Name:
Arylsulfatase H

# Macromolecular_Interacting_Partner_26_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_26_Gene_Name:
ARSH

# Macromolecular_Interacting_Partner_26_Protein_Sequence:
>Arylsulfatase 
HMTRNARPNIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSR
AAFLTGRYPIRSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKLLQHRGYRTGLIGKWHLG
LSCASRNDHCYHPLNHGFHYFYGVPFGLLSDCQASKTPELHRWLRIKLWISTVALALVPF
LLLIPKFARWFSVPWKVIFVFALLAFLFFTSWYSSYGFTRRWNCILMRNHEIIQQPMKEE
KVASLMLKEALAFIERYKREPFLLFFSFLHVHTPLISKKKFVGRSKYGRYGDNVEEMDWM
VGKILDALDQERLANHTLVYFTSDNGGHLEPLDGAVQLGGWNGIYKGGKGMGGWEGGIRV
PGIFRWPSVLEAGRVINEPTSLMDIYPTLSYIGGGILSQDRVIDGQNLMPLLEGRASHSD
HEFLFHYCGVYLHTVRWHQKDCATVWKAHYVTPKFYPEGTGACYGSGICSCSGDVTYHDP
PLLFDISRDPSEALPLNPDNEPLFDSVIKKMEAAIREHRRTLTPVPQQFSVFNTIWKPWL
QPCCGTFPFCGCDKEDDILPMAP

# Macromolecular_Interacting_Partner_26_Number_of_Residues:
562

# Macromolecular_Interacting_Partner_26_Molecular_Weight:
63526

# Macromolecular_Interacting_Partner_26_Theoretical_pI:
8.24

# Macromolecular_Interacting_Partner_26_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  sulfuric ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_26_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_26_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_26_Pathway:
Not Available

# Macromolecular_Interacting_Partner_26_Reaction:
Not Available

# Macromolecular_Interacting_Partner_26_Pfam_Domain_Function:
PF00884:Sulfatase

# Macromolecular_Interacting_Partner_26_Signals:
1-20

# Macromolecular_Interacting_Partner_26_Transmembrane_Regions:
167-189; 196-218

# Macromolecular_Interacting_Partner_26_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_26_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_26_GenBank_ID_Protein:
58201090

# Macromolecular_Interacting_Partner_26_SwissProt_ID:
Q5FYA8_HUMAN (Q5FYA8)

# Macromolecular_Interacting_Partner_26_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_26_Genecard_id:
ARSH

# Macromolecular_Interacting_Partner_26_Geneatlas_id:
ARSH

# Macromolecular_Interacting_Partner_26_hgnc_id:
HGNC:32488

# Macromolecular_Interacting_Partner_26_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_26_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_26_Gene_Sequence:
>1689 bp
ATGACAAGAAACGCCAGACCCAACATTGTCCTGCTGATGGCAGATGACCTTGGAGTGGGG
GATTTGTGCTGCTACGGTAATAACTCAGTGAGCACACCTAATATTGACCGCCTGGCAAGT
GAAGGAGTGAGGCTTACCCAGCATCTCGCAGCTGCTTCCATGTGCACCCCAAGTCGGGCT
GCCTTCCTGACCGGCCGGTACCCCATCAGATCAGGGATGGTGTCTGCCTACAACCTGAAC
CGTGCCTTCACGTGGCTTGGTGGGTCAGGTGGTCTTCCCACCAATGAAACGACTTTTGCC
AAGCTGCTGCAGCACCGTGGCTACCGCACGGGACTCATAGGCAAATGGCACCTGGGTTTG
AGCTGCGCCTCTCGGAATGATCACTGTTACCACCCGCTCAACCATGGTTTTCACTACTTT
TACGGGGTGCCTTTTGGACTTTTAAGCGACTGCCAGGCATCCAAGACACCAGAACTGCAC
CGCTGGCTCAGGATCAAACTGTGGATCTCCACGGTAGCCCTTGCCCTGGTTCCTTTTCTG
CTTCTCATTCCCAAGTTCGCCCGCTGGTTCTCAGTGCCATGGAAGGTCATCTTTGTCTTT
GCTCTCCTCGCCTTTCTGTTTTTCACTTCCTGGTACTCTAGTTATGGATTTACTCGACGT
TGGAATTGCATCCTTATGAGGAACCATGAAATTATCCAGCAGCCAATGAAAGAGGAGAAA
GTAGCTTCCCTCATGCTGAAGGAGGCACTTGCTTTCATTGAAAGGTACAAAAGGGAACCT
TTTCTCCTCTTTTTTTCCTTCCTGCACGTACATACTCCACTCATCTCCAAAAAGAAGTTT
GTTGGGCGCAGTAAATATGGCAGGTATGGGGACAATGTAGAAGAAATGGATTGGATGGTG
GGTAAAATCCTGGATGCCCTGGACCAGGAGCGCCTGGCCAACCACACCTTGGTGTACTTC
ACCTCTGACAACGGGGGCCACCTGGAGCCCCTGGACGGGGCTGTTCAGCTGGGTGGCTGG
AACGGGATCTACAAAGGTGGCAAAGGAATGGGAGGATGGGAAGGAGGTATCCGTGTGCCA
GGGATATTCCGGTGGCCGTCAGTCTTGGAGGCTGGGAGAGTGATCAATGAGCCCACCAGC
TTAATGGACATCTATCCGACGCTGTCTTATATAGGCGGAGGGATCTTGTCCCAGGACAGA
GTGATTGACGGCCAGAACCTAATGCCCCTGCTGGAAGGAAGGGCGTCCCACTCCGACCAC
GAGTTCCTCTTCCACTACTGTGGGGTCTATCTGCACACGGTCAGGTGGCATCAGAAGGAC
TGTGCAACTGTGTGGAAAGCTCATTATGTGACTCCTAAATTCTACCCTGAAGGAACAGGT
GCCTGCTATGGGAGTGGAATATGTTCATGTTCGGGGGATGTAACCTACCACGACCCACCA
CTCCTCTTTGACATCTCAAGAGACCCTTCAGAAGCCCTTCCACTGAACCCTGACAATGAG
CCATTATTTGACTCCGTGATCAAAAAGATGGAGGCAGCCATAAGAGAGCATCGTAGGACA
CTAACACCTGTCCCACAGCAGTTCTCTGTGTTCAACACAATTTGGAAACCATGGCTGCAG
CCTTGCTGTGGGACCTTCCCCTTCTGTGGGTGTGACAAGGAAGATGACATCCTTCCCATG
GCTCCCTGA

# Macromolecular_Interacting_Partner_26_GenBank_ID_Gene:
AY875940

# Macromolecular_Interacting_Partner_26_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_26_Locus:
Xp22.33

# Macromolecular_Interacting_Partner_26_SNPs:
rs5939407; rs1454503; rs5982981; rs5939151; rs7878711; rs11152555; rs5939406; rs10871873; rs5939153; rs1551377; rs5939409; rs10871872; rs5939411; rs11797171; rs5939154; rs5982633; rs1454502; rs768941; rs7876301; rs5982984; rs5982634; rs7055072; rs5982982; rs5939410; rs5939405; rs7887666; rs1966877; rs7054514; rs5982631; rs5982630; rs5982632; rs4892830; rs5939155; rs5939403; rs12008721; rs12837493; rs35887067; rs3032484; rs5982988; rs34159019; rs5901217; rs12388937; rs35728409; rs7056073; rs12686935; rs6642089; rs34048384; rs10640106; rs5939404; rs1966876; rs1470938; rs5901218; rs7474014; rs34665753; rs5939152; rs34208985; rs5982985; rs768942; rs12833818; rs5982979; rs10609103; rs7051141; rs7054744; rs5982986; rs34659109; rs35192045; rs34062456; rs11357665; rs10605342; rs12389115; rs3032483; rs10606600; rs34748096; rs34062105; rs5982987; rs5982980; rs34211469; rs35756988; rs34714250; rs5982983; rs4892829; rs34745750; rs6642088; rs7892360; rs34081662; rs36092856; rs12863026; rs12115962; rs12391596; rs12837470; rs12843021; rs12856832; rs17051460; rs17051461; rs17051467; rs1860008; rs2368456; rs4892912; rs5939158; rs5982635; rs6642092; rs6655048; rs7889997

# Macromolecular_Interacting_Partner_26_General_References:
Not Available

# Macromolecular_Interacting_Partner_26_References:
14730196; 15607112; 15735572; 15927368

End of HMDB00077

Beginning of HMDB00078
# Accession_No:
HMDB00078

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-10 12:01:36

# biospider_lastupdate:
2007-07-24 13:56:14

# Common_Name:
Cysteinylglycine

# Description:
Cysteinylglycine is a naturally occurring dipeptide.  It is derived from the breakdown of glutathione (a tripeptide).  In plasma, cysteinylglycine is in a reduced, oxidized and protein-bound form (aminothiol) and interact via redox and disulphide exchange reactions, in a dynamic system referred to as redox thiol status. (PMID 8642471) Spermatozoa of sub fertile men contain significantly higher thiol concentrations as compared with those of fertile men. The detrimental effect on embryo quality of a high homocysteine (Hcy, another member of the thiol group) concentration in the ejaculate and in follicular fluid is intriguing and may suggest that Hcy is inversely associated with fertility outcome. (PMID 16556671) Rheumatoid arthritis (RA) is a chronic inflammatory disease which involves the synovial membrane of multiple diarthroidal joints causing damage to cartilage and bones. The damage process seems to be related to an overproduction of oxygen reactive species inducing an oxidative perturbation with an increase in some oxidized forms (disulfides and protein mixed disulfides) and a decrease in free thiols. (PMID 15895891) Imipenem (thienamycin formamidine), is a broad-spectrum beta-lactam antibiotic, always used in combination with cilastatin in order to avoid the premature breakdown of imipenem by renal tubular dipeptidase. As this dipeptidase also hydrolyzes the glutathione metabolite cysteinylglycine, the therapeutic association of imipenem and cilastatin causes plasma levels of cysteinylglycine to increase significantly, while cysteine levels are decreased and homocysteine levels are unaffected. Therefore, antibiotic treatment using imipenem-cilastatin induces important metabolic changes that should not remain unrecognized. (PMID 15843241)

# Synonyms:
L-Cysteinylglycine; N-L-Cysteinylglycine; N-L-cysteinyl-Glycine; N-cysteinyl Glycine; N-cysteinyl-Glycine;Cys-Gly

# Chemical_IUPAC_Name:
2-(2-amino-3-sulfanyl-propanoyl)aminoacetic acid

# Chemical_Formula:
C5H10N2O3S

# Chemical_Structure:
tbl_chemical:::HMDB00078_ZOOM.png:::119283177824930836

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00078_THUMB.png:::119283177667232830

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid; secondary carboxylic acid amide; thiol (sulfanyl compound); alkylthiol

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
178.04121

# Molecular_Weight_Avg:
178.20950

# Smiles_String_isomeric:
N[C@@H](CS)C(=O)NCC(O)=O

# Smiles_String_canonical:
NC(CS)C(=O)NCC(O)=O

# KEGG_Compound_ID:
C01419

# BioCyc_ID:
GLUTATHIONE

# PubChem_CID:
439498

# PubChem_SID:
16178950; 4606; 10298348

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
1445980

# Wikipedia_ID:
Not Available

# METLIN_ID:
5134

# Ref_ID:
7333014; 15900404; 15229171; 9554495; 1632485; 8432015; 14961880; 14649736; 9870205; 9751082; 8087981; 12929176; 14637266; 8353942; 6746837

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
19246-18-5

# InChI:
InChI=1/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1

# Synthesis_Reference:
Journal of Medicinal Chemistry  (2005),  48(13),  4410-4419.

# Melting_Point:
Not Available

# Melting_Point_predicted:
44.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
6.25 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.58 [Predicted by ALOGPS]; -3.4 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Cysteinylglycine.mol:::1132723805484937942

# SDF_File_[Text]:
tbl_chemical:::HMDB00078.sdf:::11928317727833129

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00078.pdb:::119283177530646383

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Cysteinylglycine.gif:::1132732106234174891

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00078_peaks.txt:::1156309531747628865

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Cysteinylglycine_C.gif:::1132737677466856462

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00078_peaks.txt:::1156310722084492535

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; Extracellular

# Tissue_Location:
Most Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Urine	0.48 +/- 0.15	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	6746837
Blood	65.7	uM	Adult:>18_yrs_old	Male	Normal	9554495
Blood	13.6 +/- 3.6	uM	Adult:>18_yrs_old	Both	Normal	7333014
Blood	51.7 +/- 1.7	uM	Infant:0-1_yr_old	Male	Normal	9554495
Blood	63.4 +/- 7.4	uM	Children:1-13_yrs_old	Male	Normal	9554495
Blood	54.0 +/- 18.8	uM	Adolescent:13-18_yrs_old	Male	Normal	9554495
Blood	56.0 +/- 7.0	uM	Children:1-13_yrs_old	Female	Normal	9554495
Blood	51.8 +/- 4.9	uM	Infant:0-1_yr_old	Female	Normal	9554495
Blood	57.5 +/- 5.9	uM	Adolescent:13-18_yrs_old	Female	Normal	9554495
Blood	53.2 +/- 7.7	uM	Adult:>18_yrs_old	Female	Normal	9554495
Cerebrospinal_Fluid(CSF)	2.31 (0.99-3.62)	umol/L	Adult:>18_yrs_old	Both	Normal	9870205
Saliva	0.00605 +/- 0.00512	uM	Adult:>18_yrs_old	Both	Normal	15900404


# Concentration_[Abnormal]:
Blood	6.0 (2.0-10.0)	uM	Adult:>18_yrs_old	Both	Phenylketonuria (PKU)	7333014


# Associated_Disorders:
Homocystinuria; Phenylketonuria (PKU); Pyroglutamic acidemia

# Pathway_Names:
Glutathione metabolism;Prostaglandin and leukotriene metabolism

# Pathway_Images:
;

# KEGG_Images:
map00480;map0059

# Pathway_Graphs:
;

# Pathway_SBMLs:
;

# Metabolic_Enzyme_1_ID:
5686

# Metabolic_Enzyme_1_Name:
Aminopeptidase N

# Metabolic_Enzyme_1_Synonyms:
hAPN; Alanyl aminopeptidase; Microsomal aminopeptidase; Aminopeptidase M; gp150; Myeloid plasma membrane glycoprotein CD13; CD13 antigen

# Metabolic_Enzyme_1_Gene_Name:
ANPEP

# Metabolic_Enzyme_1_Protein_Sequence:
>Aminopeptidase 
NMAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNP
ASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDV
IIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMD
SEFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIH
PKDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVL
IRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGL
VTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEY
LGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSK
GASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDI
MNRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQD
YWLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRA
QIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMK
NYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQW
MENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELW
ILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFS
NLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVL
QWFTENSK

# Metabolic_Enzyme_1_Number_of_Residues:
967

# Metabolic_Enzyme_1_Molecular_Weight:
109540

# Metabolic_Enzyme_1_Theoretical_pI:
5.14

# Metabolic_Enzyme_1_GO_Classification:
Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection

# Metabolic_Enzyme_1_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_1_Reaction:
Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide

# Metabolic_Enzyme_1_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_1_Signals:
1-22

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.4.11.2

# Metabolic_Enzyme_1_GenBank_ID_Protein:
28678

# Metabolic_Enzyme_1_SwissProt_ID:
AMPN_HUMAN (P15144)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ANPEP

# Metabolic_Enzyme_1_Geneatlas_id:
ANPEP

# Metabolic_Enzyme_1_hgnc_id:
HGNC:500

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Cytoplasm; cytosol (Potential). Note=A soluble form has also been detected

# Metabolic_Enzyme_1_Gene_Sequence:
>2904 bp
ATGGCCAAGGGCTTCTATATTTCCAAGTCCCTGGGCATCCTGGGGATCCTCCTGGGCGTG
GCAGCCGTGTGCACAATCATCGCACTGTCAGTGGTGTACTCCCAGGAGAAGAACAAGAAC
GCCAACAGCTCCCCCGTGGCCTCCACCACCCCGTCCGCCTCAGCCACCACCAACCCCGCC
TCGGCCACCACCTTGGACCAAAGTAAAGCGTGGAATCGTTACCGCCTCCCCAACACGCTG
AAACCCGATTCCTACCAGGTGACGCTGAGACCGTACCTCACCCCCAATGACAGGGGCCTG
TACGTTTTTAAGGGCTCCAGCACCGTCCGTTTCACCTGCAAGGAGGCCACTGACGTCATC
ATCATCCACAGCAAGAAGCTCAACTACACCCTCAGCCAGGGGCACAGGGTGGTCCTGCGT
GGTGTGGGAGGCTCCCAGCCCCCCGACATTGACAAGACTGAGCTGGTGGAGCCCACCGAG
TACCTGGTGGTGCACCTCAAGGGCTCCCTGGTGAAGGACAGCCAGTATGAGATGGACAGC
GAGTTCGAGGGGGAGTTGGCAGATGACCTGGCGGGCTTCTACCGCAGCGAGTACATGGAG
GGCAATGTCAGAAAGGTGGTGGCCACTACACAGATGCAGGCTGCAGATGCCCGGAAGTCC
TTCCCATGCTTCGATGAGCCGGCCATGAAGGCCGAGTTCAACATCACGCTTATCCACCCC
AAGGACCTGACAGCCCTGTCCAACATGCTTCCCAAAGGTCCCAGCACCCCACTTCCAGAA
GACCCCAACTGGAATGTCACTGAGTTCCACACCACGCCCAAGATGTCCACGTACTTGCTG
GCCTTCATTGTCAGTGAGTTCGACTACGTGGAGAAGCAGGCATCCAATGGTGTCTTGATC
CGGATCTGGGCCCGGCCCAGTGCCATTGCGGCGGGCCACGGCGATTATGCCCTGAACGTG
ACGGGCCCCATCCTTAACTTCTTTGCTGGTCATTATGACACACCCTACCCACTCCCAAAA
TCAGACCAGATTGGCCTGCCAGACTTCAACGCCGGCGCCATGGAGAACTGGGGACTGGTG
ACCTACCGGGAGAACTCCCTGCTGTTCGACCCCCTGTCCTCCTCCAGCAGCAACAAGGAG
CGGGTGGTCACTGTGATTGCTCATGAGCTGGCCCACCAGTGGTTCGGGAACCTGGTGACC
ATAGAGTGGTGGAATGACCTGTGGCTGAACGAGGGCTTCGCCTCCTACGTGGAGTACCTG
GGTGCTGACTATGCGGAGCCCACCTGGAACTTGAAAGACCTCATGGTGCTGAATGATGTG
TACCGCGTGATGGCAGTGGATGCACTGGCCTCCTCCCACCCGCTGTCCACACCCGCCTCG
GAGATCAACACGCCGGCCCAGATCAGTGAGCTGTTTGACGCCATCTCCTACAGCAAGGGC
GCCTCAGTCCTCAGGATGCTCTCCAGCTTCCTGTCCGAGGACGTATTCAAGCAGGGCCTG
GCGTCCTACCTCCACACCTTTGCCTACCAGAACACCATCTACCTGAACCTGTGGGACCAC
CTGCAGGAGGCTGTGAACAACCGGTCCATCCAACTCCCCACCACCGAGCGGGACATCATG
AACCGCTGGACCCTGCAGATGGGCTTCCCGGTCATCACGGTGGATACCAGCACGGGGACC
CTTTCCCAGGAGCACTTCCTCCTTGACCCCGATTCCAATGTTACCCGCCCCTCAGAATTC
AACTACGTGTGGATTGTGCCCATCACATCCATCAGAGATGGCAGACAGCAGCAGGACTAC
TGGCTGATGGATGTAAGAGCCCAGAACGATCTCTTCAGCACATCAGGCAATGAGTGGGTC
CTGCTGAACCTCAATGTGACGGGCTATTACCGGGTGAACTACGACGAAGAGAACTGGAGG
AAGATTCAGACTCAGCTGCAGAGAGACCACTCGGCCATCCCTGTCATCAATCGGGCACAG
ATCATTAATGACGCCTTCAACCTGGCCAGTGCCCATAAGGTCCCTGTCACTCTGGCGCTG
AACAACACCCTCTTCCTGATTGAAGAGAGACAGTACATGCCCTGGGAGGCCGCCCTGAGC
AGCCTGAGCTACTTCAAGCTCATGTTTGACCGCTCCGAGGTCTATGGCCCCATGAAGAAC
TACCTGAAGAAGCAGGTCACACCCCTCTTCATTCACTTCAGAAATAATACCAACAACTGG
AGGGAGATCCCAGAAAACCTGATGGACCAGTACAGCGAGGTTAATGCCATCAGCACCGCC
TGCTCCAACGGAGTTCCAGAGTGTGAGGAGATGGTCTCTGGCCTTTTCAAGCAGTGGATG
GAGAACCCCAATAATAACCCGATCCACCCCAACCTGCGGTCCACCGTCTACTGCAACGCT
ATCGCCCAGGGCGGGGAGGAGGAGTGGGACTTCGCCTGGGAGCAGTTCCGAAATGCCACA
CTGGTCAATGAGGCTGACAAGCTCCGGGCAGCCCTGGCCTGCAGCAAAGAGTTGTGGATC
CTGAACAGGTACCTGAGCTACACCCTGAACCCGGACTTAATCCGGAAGCAGGACGCCACC
TCTACCATCATCAGCATTACCAACAACGTCATTGGGCAAGGTCTGGTCTGGGACTTTGTC
CAGAGCAACTGGAAGAAGCCTTTTAACGATTATGGTGGTGGCTCGTTCTCCTTCTCCAAC
CTCATCCAGGCAGTGACACGACGATTCTCCACCGAGTATGAGCTGCAGCAGCTGGAGCAG
TTCAAGAAGGACAACGAGGAAACAGGCTTCGGCTCAGGCACCCGGGCCCTGGAGCAAGCC
CTGGAGAAGACGAAAGCCAACATCAAGTGGGTGAAGGAGAACAAGGAGGTGGTGCTCCAG
TGGTTCACAGAAAACAGCAAATAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X13276

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_1_Locus:
15q25-q26

# Metabolic_Enzyme_1_SNPs:
rs25653; rs8192297; rs17240268; rs25651; rs17240212; rs17240240; rs25654; rs25652; rs10584; rs1439118; rs6496603; rs893615; rs1439121; rs1992250; rs8035491; rs753362; rs12909844; rs8192299; rs6496604; rs16943605; rs7169049; rs7168329; rs17239917; rs2305443; rs16943599; rs6496605; rs7168849; rs7169161; rs7166568; rs8192300; rs16943590; rs16974177; rs12324351; rs1439119; rs1439117; rs12437542; rs9672394; rs11857171; rs8036014; rs2305444; rs1439120; rs7167568; rs11857950; rs11854430; rs8192298; rs2007084; rs3934; rs16974181; rs10152918; rs6496606; rs893616; rs8035089; rs751218; rs8034807; rs967451; rs13380049; rs12921; rs8179192; rs10152474; rs1042550; rs8179195; rs8179199; rs41276922; rs8192296; rs41276916; rs1803099; rs41276910; rs1042524; rs1803100; rs8192295; rs11548402; rs5017001; rs1042499; rs28760317; rs41276918; rs10596905; rs28569158; rs34455433; rs755494; rs8192301; rs28546242; rs8179198; rs8192294; rs8023978; rs28512252; rs28454285; rs28826912; rs35119955; rs10596904; rs34462972; rs28699258; rs28375428; rs35916600; rs8043481; rs41276912; rs3214806; rs28463231; rs34392936; rs28545693; rs8039818; rs28639834; rs28787610; rs8192302; rs35107174; rs28588889; rs35792576; rs28626435; rs10652893; rs28731015; rs34558689; rs28404753; rs28445667; rs8179197; rs36038374; rs11419701; rs35929320; rs28465343; rs11396899; rs934922; rs35626130; rs35391151; rs28654076; rs8024295; rs28462367; rs34396448; rs28621548; rs28493892; rs8030846; rs41276920; rs35499425; rs28422990; rs28638060; rs28380038; rs8028356; rs8031558; rs35579820; rs8025757; rs8192293; rs33964101; rs28556743; rs10643405; rs35273925; rs10683900; rs35962063; rs41276914; rs28591352; rs11428754; rs34474497; rs34493756; rs28459313; rs28496328; rs35408448; rs7175307; rs41276924; rs28368179; rs28698386; rs16943583; rs28460748; rs13380065; rs4932142; rs28575419; rs35816703; rs34025860; rs11073889; rs11632886; rs11636959; rs11857170; rs12900413; rs12908026; rs12908343; rs12908545; rs12910894; rs12913572; rs1561459; rs3929141; rs8041622

# Metabolic_Enzyme_1_General_References:
2901990; 2564851; 1675638; 7576235; 8102610; 6149934; 1705556; 1350662; 7902291; 8105105; 8887485; 9056417; 9367365; 9634079; 10605003; 10676659; 11384645; 11559807; 12473585; 12551991; 9452074

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6004

# Metabolic_Enzyme_2_Name:
Gamma-glutamyltransferase 5 precursor

# Metabolic_Enzyme_2_Synonyms:
Gamma- glutamyltranspeptidase 5; Gamma-glutamyltransferase-like activity 1; GGT-rel[Contains: Gamma-glutamyltransferase 5 heavy chain; Gamma- glutamyltransferase 5 light chain]

# Metabolic_Enzyme_2_Gene_Name:
GGTLA1

# Metabolic_Enzyme_2_Protein_Sequence:
>Gammaglutamyltransferase 5 precursor
MARGYGATVSLVLLGLGLALAVIVLAVVLSRHQAPCGPQAFAHAAVAADSKVCSDIGRAI
LQQQGSPVDA
TIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPASHAP
SLLDQCAQALPLGTGAQWIGV
PGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAP
VLSRFLHNSILRPSLQASTLRQLFFNGTEPLR
PQDPLPWPALATTLETVATEGVEVFYT
GRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTL
YSPPPPAGGAILSFIL
NVLRGFNFSTESMARPEGRVNVYHHLVETLKFAKGQRWRLGDPRSHPKLQNASR
DLLGE
TLAQLIRQQIDGRGDHQLSHYSLAEAWGHGTGTSHVSVLGEDGSAVAATSTINTPFGAMV
YSPRT
GIILNNELLDLCERCPRGSGTTPSPVSGDRVGGAPGRCWPPVPGERSPSSMVPS
ILINKAQGSKLVIGGA
GGELIISAVAQAIMSKLWLGFDLRAAIAAPILHVNSKGCVEYE
PNFSQEVQRGLQDRGQNQTQRPFFLNV
VQAVSQEGACVYAVSDLRKSGEAAGY

# Metabolic_Enzyme_2_Number_of_Residues:
586

# Metabolic_Enzyme_2_Molecular_Weight:
62262

# Metabolic_Enzyme_2_Theoretical_pI:
7.59

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring amino-acyl groups
Function:  gamma-glutamyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4)

# Metabolic_Enzyme_2_Pathway:
map00430  Taurine and hypotaurine metabolism;
 map00450  Selenoamino acid metabolism;
 map00460  Cyanoamino acid metabolism;
 map00480  Glutathione metabolism;
 map00590  Prostaglandin and leukotriene metabolism

# Metabolic_Enzyme_2_Reaction:
(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01019:G_glu_transpept

# Metabolic_Enzyme_2_Signals:
1-26

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.3.2.2

# Metabolic_Enzyme_2_GenBank_ID_Protein:
183142

# Metabolic_Enzyme_2_SwissProt_ID:
GGT5_HUMAN (P36269)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
GGTLA1

# Metabolic_Enzyme_2_Geneatlas_id:
GGTLA1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:4260

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_2_Gene_Sequence:
>1761 bp

ATGGCCCGGGGCTACGGGGCCACGGTCAGCCTAGTCCTGCTGGGTCTGGGGCTGGCGCT
GGCTGTCATTG
TGCTGGCTGTGGTCCTCTCTCGACACCAGGCCCCATGTGGCCCCCAGG
CCTTTGCCCACGCTGCTGTTGC
CGCCGACTCCAAGGTCTGCTCGGATATTGGACGAGCC
ATCCTCCAGCAGCAGGGCTCACCCGTGGATGCC
ACCATCGCGGCTCTGGTCTGCACCAG
CGTCGTCAACCCTCAGAGCATGGGCCTGGGCGGAGGGGTCATCT
TCACCATCTACAATG
TGACAACAGGGAAGGTGGAGGTCATCAATGCCCGGGAGACGGTGCCGGCCAGCCA
CGCC
CCGAGCCTGCTGGACCAGTGTGCACAGGCTCTGCCACTGGGCACAGGGGCCCAGTGGATC
GGGGTG
CCCGGGGAGCTCCGTGGCTATGCCGAGGCCCACCGCCGCCATGGCCGCCTGCC
CTGGGCGCAGCTGTTCC
AGCCCACCATCGCGCTGCTCCGAGGGGGGCATGTGGTGGCCC
CTGTCCTCAGCCGTTTCCTGCACAACAG
CATCCTGCGGCCTTCCTTGCAGGCGTCAACC
CTGCGCCAGCTCTTCTTCAACGGGACAGAACCCCTGAGG
CCTCAGGACCCACTCCCATG
GCCTGCACTGGCCACCACCCTGGAGACCGTGGCCACAGAGGGCGTGGAGG
TCTTCTACA
CGGGGAGGCTGGGCCAGATGCTGGTGGAGGACATTGCCAAGGAAGGGAGCCAGCTGACGC
T
GCAGGACCTGGCCAAGTTCCAGCCCGAGGTGGTGGATGCCCTGGAGGTGCCCCTGGGG
GACTATACCCTG
TACTCACCACCGCCGCCTGCAGGGGGTGCCATTCTCAGCTTTATCCT
CAACGTGCTAAGAGGGTTCAACT
TCTCAACAGAGTCTATGGCCAGGCCTGAAGGGAGGG
TGAACGTGTACCACCACCTTGTAGAGACGCTCAA
GTTTGCCAGGGGGCAGAGGTGGAGG
CTGGGGGACCCTCGAAGCCACCCGAAGCTCCAGAATGCCTCCCGG
GACCTGCTGGGGGA
GACCCTGGCCCAGCTCATCCGCCAACAGATCGATGGCCGGGGGGACCACCAGCTCA
GCC
ACTACAGCTTGGCCGAGGCCTGGGGCCACGGGACAGGCACGTCCCATGTGTCTGTGCTGG
GGGAGGA
TGGCAGCGCCGTGGCTGCCACCAGCACCATCAACACACCCTTTGGAGCGATG
GTGTATTCACCACGGACA
GGCATCATCCTCAACAACGAGCTCCTGGACTTATGCGAGCG
ATGCCCCTGGGGTTCCGGCACCACCCCCT
CACCTGTGAGTGGAGACAGGGTGGGTGGAG
CTCCCGGAAGGTGCTGGCCCCCAGTTCCAGGCGAGCGTTC
CCCATCCTCCATGGTGCCC
TCCATCTTGATCAACAAAGCCCAGGGGTCGAAGCTAGTGATTGGCGGGGCT
GGCGGGGA
GCTCATCATCTCTGCTGTGGCCCAGGCCATCATGAGCAAGCTGTGGCTTGGCTTTGACCT
GA
GAGCGGCCATTGCAGCCCCCATCCTGCATGTCAACAGCAAGGGCTGTGTGGAGTACG
AGCCCAACTTCAG
CCAGGAGGTGCAGAGGGGACTCCAAGACCGTGGCCAGAACCAGACC
CAGAGGCCCTTCTTCCTGAACGTG
GTCCAGGCTGTGTCCCAGGAGGGGGCCTGTGTGTA
CGCCGTCTCGGACCTGAGGAAGAGTGGGGAGGCCG
CAGGCTACTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M64099

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_2_Locus:
22q11.23

# Metabolic_Enzyme_2_SNPs:
rs7288201; rs2275984; rs762276; rs4443101; rs8140505; rs2267073; rs8135709; rs2267074; rs5996675; rs5996676; rs8142702; rs4822473; rs8140559; rs5751820; rs2275985; rs5751822; rs5760273; rs9612567; rs7286769; rs12627971; rs8141279; rs2330738; rs9608253; rs5760270; rs9608254; rs6004109; rs6004104; rs8135864; rs7288670; rs7286276; rs9608250; rs5760271; rs2877206; rs5751821; rs518219; rs9612575; rs2275983; rs7286275; rs6004103; rs9608256; rs915597; rs9608255; rs738810; rs2078191; rs11090315; rs13053599; rs12166260; rs11913528; rs5751819; rs5760274; rs6004105; rs8142028; rs34787869; rs3171733; rs28470453; rs35519802; rs4049960; rs8141921; rs2186375; rs11446984; rs11912938; rs35151649; rs9608251; rs34162764; rs9612568; rs34456415; rs36080744; rs9608261; rs507572; rs12158478; rs8141917; rs7288678; rs9612571; rs12169644; rs4049956; rs9624432; rs8140966; rs8140009; rs12170724; rs35658121; rs12165595; rs13054993; rs34139406; rs36078496; rs5760272; rs28558344; rs2196265; rs7286843; rs34408756; rs9612569; rs9608257; rs6004107; rs8140350; rs7289730; rs28765434; rs28581334; rs34254169; rs915596; rs9608263; rs9608258; rs35424805; rs9624434; rs9624435; rs4049959; rs8142438; rs5760267; rs34213657; rs8137278; rs34286685; rs35687403; rs507543; rs28433519; rs9612570; rs9608252; rs6004108; rs5760268; rs34690574; rs35456290; rs35720801; rs34544519; rs507578; rs35482725; rs8141879; rs13056182; rs35048159; rs35924097; rs34183480; rs35060391; rs4049958; rs35676668; rs9612572; rs5760269; rs35673322; rs8137410; rs9608260; rs7285631; rs13054426; rs2154608; rs35357003; rs34686376; rs7291369; rs2186373; rs9680720; rs35387722; rs9608262; rs10428035; rs12158941; rs13054853; rs2186374; rs3966270; rs11913894; rs7290701; rs10427555; rs34505104; rs7291063; rs8142646; rs12169182; rs4049957; rs12160538; rs34593708; rs8136200; rs13054966; rs9608259; rs507542; rs4049961; rs5760266; rs4408818; rs28562380; rs9624430; rs8137281; rs35334731; rs204713; rs12159878; rs5760265; rs7289030; rs34949320; rs34303680; rs34756406; rs28503851; rs13055027; rs13057276; rs12166267; rs9608249; rs35351787; rs34288539; rs28447258; rs28480057; rs28635067; rs34513858; rs35229275; rs583199; rs5996674; rs6004094; rs6004099; rs743359; rs743360; rs9612564

# Metabolic_Enzyme_2_General_References:
1676842; 10591208

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6005

# Metabolic_Enzyme_3_Name:
Gamma-glutamyltranspeptidase 1 precursor

# Metabolic_Enzyme_3_Synonyms:
Gamma- glutamyltransferase 1; GGT 1; CD224 antigen[Contains: Gamma- glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain]

# Metabolic_Enzyme_3_Gene_Name:
GGT1

# Metabolic_Enzyme_3_Protein_Sequence:
>Gammaglutamyltranspeptidase 1 precursor
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRD
GGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMFN
SSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALEN
KRTVIEQQPVLCEVFCRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKD
IQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSR
ESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISD
DTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNE
MDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTA
TALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTF
IAVVQAIVRTAGGWAAASDSRKGGEPAGY

# Metabolic_Enzyme_3_Number_of_Residues:
569

# Metabolic_Enzyme_3_Molecular_Weight:
61411

# Metabolic_Enzyme_3_Theoretical_pI:
7.14

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring amino-acyl groups
Function:  gamma-glutamyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive

# Metabolic_Enzyme_3_Pathway:
map00430  Taurine and hypotaurine metabolism;
 map00450  Selenoamino acid metabolism;
 map00460  Cyanoamino acid metabolism;
 map00480  Glutathione metabolism;
 map00590  Prostaglandin and leukotriene metabolism

# Metabolic_Enzyme_3_Reaction:
(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01019:G_glu_transpept

# Metabolic_Enzyme_3_Signals:
1-30

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.3.2.2

# Metabolic_Enzyme_3_GenBank_ID_Protein:
183138

# Metabolic_Enzyme_3_SwissProt_ID:
GGT1_HUMAN (P19440)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
GGT1

# Metabolic_Enzyme_3_Geneatlas_id:
GGT1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:4250

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_3_Gene_Sequence:
>1710 bp
ATGAAGAAGAAGTTAGTGGTGCTGGGCCTGCTGGCCGTGGTCCTGGTGCTGGTCATTGTC
GGCCTCTGTCTCTGGCTGCCCTCAGCCTCCAAGGAACCTGACAACCATGTGTACACCAGG
GCTGCCGTGGCCGCGGATGCCAAGCAGTGCTCGAAGATTGGGAGGGATGCACTGCGGGAC
GGTGGCTCTGCGGTGGATGCAGCCATTGCAGCCCTGTTGTGTGTGGGGCTCATGAATGCC
CACAGCATGGGCATCGGGGGTGGCCTCTTCCTCACCATCTACAACAGCACCACACGAAAA
GCTGAGGTCATCAACGCCCGCGAGGTGGCCCCCAGGCTGGCCTTTGCCACCATGTTCAAC
AGCTCGGAGCAGTCCCAGAAGGGGGGGCTGTCGGTGGCGGTGCCTGGGGAGATCCGAGGC
TATGAGCTGGCACACCAGCGGCATGGGCGGCTGCCCTGGGCTCGCCTCTTCCAGCCCAGC
ATCCAGCTGGCCCGCCAGGGCTTCCCCGTGGGCAAGGGCTTGGCGGCAGCCCTGGAAAAC
AAGCGGACCGTCATCGAGCAGCAGCCTGTCTTGTGTGAGGTGTTCTGCCGGGATAGAAAG
GTGCTTCGGGAGGGGGAGAGACTGACCCTGCCGCAGCTGGCTGACACCTACGAGACGCTG
GCCATCGAGGGTGCCCAGGCCTTCTACAACGGCAGCCTCACGGCCCAGATTGTGAAGGAC
ATCCAGGCGGCCGGGGGCATTGTGACAGCTGAGGACCTGAACAACTACCGTGCTGAGCTG
ATCGAGCACCCGCTGAACATCAGCCTGGGAGACGCGGTGCTGTACATGCCCAGTGCGCCG
CTCAGCGGGCCCGTGCTGGCCCTCATCCTCAACATCCTCAAAGGGTACAACTTCTCCCGG
GAGAGCGTGGAGAGCCCCGAGCAGAAGGGCCTGACGTACCACCGCATCGTAGAGGCTTTC
CGGTTTGCCTACGCCAAGAGGACCCTGCTTGGGGACCCCAAGTTTGTGGATGTGACTGAG
GTGGTCCGCAACATGACCTCCGAGTTCTTCGCTGCCCAGCTCCGGGCCCAGATCTCTGAC
GACACCACTCACCCGATCTCCTACTACAAGCCCGAGTTCTACACGCCGGATGACGGGGGC
ACTGCTCACCTGTCTGTCGTCGCAGAGGACGGCAGTGCTGTGTCCGCCACCAGCACCATC
AACCTCTACTTTGGCTCCAAGGTCCGCTCCCCGGTCAGCGGGATCCTGTTCAATAATGAA
ATGGACGACTTCAGCTCTCCCAGCATCACCAACGAGTTTGGGGTACCCCCCTCACCTGCC
AATTTCATCCAGCCAGGGAAGCAGCCGCTCTCGTCCATGTGCCCGACGATCATGGTGGGC
CAGGACGGCCAGGTCCGGATGGTGGTGGGAGCTGCTGGGGGCACACAGATCACCACGGCC
ACTGCACTGGCCATCATCTACAACCTCTGGTTCGGCTATGACGTGAAGCGGGCCGTGGAG
GAGCCCCGGCTGCACAACCAGCTTCTGCCCAACGTCACGACAGTGGAGAGAAACATTGAC
CAGGCAGTGACTGCAGCCCTGGAGACCCGGCACCATCACACCCAGATCGCGTCCACCTTC
ATCGCTGTGGTGCAAGCCATCGTCCGCACGGCTGGTGGCTGGGCAGCTGCCTCGGACTCC
AGGAAAGGCGGGGAGCCTGCCGGCTACTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
J04131

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_3_Locus:
22q11.23

# Metabolic_Enzyme_3_SNPs:
rs2330837; rs3895576; rs2330838; rs2017869; rs2330795; rs2073398; rs9624507; rs2006092; rs6519520; rs5751901; rs6519519; rs7284489; rs3788375; rs7292010; rs5760495; rs4049889; rs2006094; rs5760494; rs2001180; rs6004192; rs5751905; rs5760493; rs2006227; rs9624506; rs2005589; rs4822516; rs5751904; rs2073397; rs5760492; rs2076999; rs3859862; rs2010657; rs2003757; rs16990490; rs8138050; rs4049918; rs9608300; rs2017188; rs1807629; rs2330797; rs4822517; rs6004195; rs7286626; rs3747117; rs5760491; rs2330805; rs9624510; rs743371; rs3876104; rs4820600; rs5751902; rs5760490; rs6004193; rs6004194; rs8135987; rs8139070; rs5751909; rs5751910; rs9306396; rs9612676; rs5760505; rs2330848; rs5760499; rs5760497; rs5760504; rs4049843; rs9680722; rs2330841; rs524033; rs11913233; rs9680724; rs4049855; rs380131; rs3934421; rs4822523; rs5760500; rs6004203; rs3901297; rs5760498; rs391837; rs5751908; rs9680612; rs3895577; rs4822520; rs4049869; rs3895575; rs7511507; rs7511598; rs389004; rs2236626; rs7285339; rs2330842; rs4049882; rs4049829; rs28621555; rs2330836; rs3966247; rs12159765; rs4049897; rs4049881; rs9612682; rs2330843; rs4049844; rs4049883; rs2330844; rs5751900; rs2330830; rs12169166; rs4049900; rs2330818; rs2330826; rs9624503; rs3966256; rs9612663; rs3966255; rs3895580; rs4049911; rs2877222; rs2330801; rs3033885; rs9624509; rs6004196; rs4049914; rs2330835; rs1832359; rs28509371; rs4049896; rs2298391; rs2330825; rs9624505; rs2877224; rs4049885; rs2330811; rs4049917; rs2330806; rs3876101; rs3887791; rs12484586; rs4049890; rs8139074; rs3895578; rs28550867; rs4049905; rs4049925; rs3966259; rs673673; rs753462; rs4049899; rs2330813; rs8138031; rs4049895; rs28605797; rs3966263; rs3876105; rs9612666; rs2330808; rs2330832; rs2076800; rs13057657; rs3033738; rs3966257; rs2330803; rs2330815; rs4049912; rs3033744; rs2330810; rs2330800; rs3895574; rs6004191; rs8137090; rs2330807; rs2330834; rs4049913; rs28449741; rs2330827; rs3966260; rs9624504; rs2330817; rs9612671; rs4049903; rs2877221; rs5751903; rs2330824; rs2079567; rs2330796; rs4049898; rs11913684; rs2877225; rs2330831; rs4049891; rs4049915; rs2330812; rs4049910; rs4049916; rs4049908; rs12106564; rs3876100; rs3859863; rs3032936; rs9624508; rs4049901; rs12163146; rs4049924; rs4049906; rs2330819; rs9612664; rs3788376; rs3895579; rs2330822; rs2330804; rs2330823; rs2077120; rs2089350; rs2330814; rs2006093; rs4049904; rs9608301; rs3865759; rs2330799; rs3966258; rs28566494; rs2330820; rs3876103; rs2330802; rs4049926; rs3894886; rs3966262; rs2079568; rs2330816; rs2330809; rs2330798; rs2877223; rs4049902; rs8139073; rs4049865; rs4049850; rs4049857; rs2877228; rs28663139; rs4049837; rs4049873; rs4049867; rs4049860; rs28545702; rs34659550; rs3865654; rs4049863; rs28377326; rs3865651; rs4535160; rs4049839; rs11913428; rs2096530; rs28366457; rs4049828; rs3865649; rs9608303; rs4049861; rs6004202; rs2330853; rs6004200; rs4049833; rs10602389; rs9624512; rs4049875; rs2330849; rs3865659; rs3966245; rs2330852; rs12167273; rs4049847; rs2096529; rs4049868; rs7287997; rs4049880; rs4049835; rs3865653; rs11703306; rs4049878; rs2330846; rs3865657; rs35411004; rs2330850; rs5760509; rs12168759; rs9620404; rs4049870; rs9612673; rs5760510; rs4049836; rs28441370; rs12170528; rs4049849; rs4049827; rs4049851; rs3865655; rs4049872; rs3865650; rs6004205; rs5751911; rs4049858; rs4049879; rs2877229; rs2330845; rs6004201; rs12159496; rs4426615; rs4049838; rs2877230; rs12168762; rs28418841; rs4049877; rs3876106; rs28477676; rs5760503; rs3938847; rs9620400; rs2330847; rs4049842; rs28402861; rs28718168; rs3865658; rs4049856; rs2877227; rs12166510; rs4049832; rs7284160; rs2105500; rs11416248; rs493075; rs2877231; rs3966265; rs2330851; rs3966264; rs6004198; rs3897519; rs4049864; rs4049854; rs4049830; rs3865656; rs2845424; rs9612672; rs5751465; rs4049871; rs11912608; rs9620401; rs2330840; rs4049859; rs28451181; rs4049834; rs4049862; rs9612679; rs3034881; rs4049874; rs3865652; rs35525727; rs3035043; rs12158857; rs2330854; rs35882418; rs5760483; rs11318518; rs11913638; rs12158094; rs16978739; rs2070477; rs2154611; rs4820599; rs5760485; rs5760488; rs7287904; rs737128; rs743369; rs743370; rs762286; rs874852; rs928785; rs9608299; rs9830

# Metabolic_Enzyme_3_General_References:
2904146; 2907498; 2563599; 2568315; 1968061; 1378736; 7689219; 10591208; 2896486; 10392451; 19463; 2900635; 8095045; 7759490; 7673200; 8827453

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
6006

# Metabolic_Enzyme_4_Name:
Gamma-glutamyltransferase 4 precursor

# Metabolic_Enzyme_4_Synonyms:
Gamma- glutamyltranspeptidase 4; Gamma-glutamyltransferase-like 3; Gamma- glutamyltransferase-like 5[Contains: Gamma-glutamyltransferase 4 heavy chain; Gamma-glutamyltransferase 4 light chain]

# Metabolic_Enzyme_4_Gene_Name:
GGTL3

# Metabolic_Enzyme_4_Protein_Sequence:
>Gammaglutamyltransferase 4 precursor
MAAENEASQESALGAYSPVDYMSITSFPRLPEDEPAPAAPLRGRKDEDAFLGDPDTDPDS
FLKSARLQRL
PSSSSEMGSQDGSPLRETRKDPFSAAAAECSCRQDGLTVIVTACLTFAT
GVTVALVMQIYFGDPQIFQQG
AVVTDAARCTSLGIEVLSKQGSSVDAAVAAALCLGIVA
PHSSGLGGGGVMLVHDIRRNESHLIDFRESAP
GALREETLQRSWETKVGTLPGLLVGVP
GMVKGLHEAHQLYGRLPWSQVLAFAAAVAQDGFNVTHDLARAL
AEQLPPNMSERFRETF
LPSGRPPLPGSLLHRPDLAEVLDVLGTSGPAAFYAGGNLTLEMVAEAQHAGGVI
TEEDF
SNYSALVEKPVCGVYRGHLVLSPPPPHTGPALISALNILEGFNLTSLVSREQALHWVAET
LKIAL
ALASRLGDPVYDSTITESMDDMLSKVEAAYLRGHINDSQAAPAPLLPVYELDGA
PTAAQVLIMGPDDFIV
AMVSSLNQPFGSGLITPSGILLNSQMLDFSWPNRTANHSAPSL
ENSVQPGKRPLSFLLPTVVRPAEGLCG
TYLALGANGAARGLSGLTQVLLNVLTLNRNLS
DSLARGRLHPDLQSNLLQVDSEFTEEEIEFLEARGHHV
EKVDVLSWVHGSRRTNNFIIA
VKDPRSPDAAGATIL

# Metabolic_Enzyme_4_Number_of_Residues:
666

# Metabolic_Enzyme_4_Molecular_Weight:
70838

# Metabolic_Enzyme_4_Theoretical_pI:
4.73

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring amino-acyl groups
Function:  gamma-glutamyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Cleaves glutathione conjugates

# Metabolic_Enzyme_4_Pathway:
map00430  Taurine and hypotaurine metabolism;
 map00450  Selenoamino acid metabolism;
 map00460  Cyanoamino acid metabolism;
 map00480  Glutathione metabolism;
 map00590  Prostaglandin and leukotriene metabolism

# Metabolic_Enzyme_4_Reaction:
(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01019:G_glu_transpept

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
107-127

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.3.2.2

# Metabolic_Enzyme_4_GenBank_ID_Protein:
28192538

# Metabolic_Enzyme_4_SwissProt_ID:
GGT4_HUMAN (Q9UJ14)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
GGTL3

# Metabolic_Enzyme_4_Geneatlas_id:
GGTL3

# Metabolic_Enzyme_4_hgnc_id:
HGNC:4259

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_4_Gene_Sequence:
>756 bp

ATGGCGGCGGAGAAGGAGGCCAGCCAGGAGAGCGCCCTGGGCGCCTACTCGCCAGTGGA
CTACATGAGCA
TCACCAGCTTCCCGCGGCTGCCCGAGGACGAGCCGGCGCCCGCGGCCC
CGCTGAGGGGCCGCAAGGACGA
GGACGCCTTTCTGGGAGACCCCGACACCGACCCGGAC
TCCTTCCTGAAGTCTGCACGGCTGCAGCGGCTG
CCATCGTCGTCGTCGGAGATGGGCAG
CCAAGACGGGTCGCCGCTACGCGAGACGCGCAAAGACCCGTTCT
CCGCCGCAGCGGCCG
AGTGCTCCTGCCGCCAGGATGGGCTCACGGTCATCGTCACGGCCTGTCTCACCTT
CGCT
ACCGGTGTCACCGTGGCGCTGGTCATGCAGATCTACTTCGGGGACCCCCAGATCTTCCAG
CAGGGT
GCCGTGGTGACCGATGCTGCCCGCTGCACTTCACTGGGCATCGAGGTGCTCAG
TAAACAGGGATCTTCTG
TGGACGCAGCGGTGGCAGCAGCCTTGTGTTTGGGTATCGTGG
CTCCACACAGTTCTGGCCTGGGCGGTGG
GGGCGTGATGCTGGTACATGACATCCGACGA
AATGAGAGCCACCTAATTGATTTCCGGGAGTCCGCACCA
GGGGCCCTCAGGGAAGAGAC
CCTGCAAAGATCCTGGGAGACCAAGGTGGGGACCCTGGTGAGAAGAGAGA
GTTCAGGGG
AGTCTCTCTTCATTGCCCTTCTGCTAACCCAAGCATTAATTTGCTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AY138815

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_4_Locus:
20q11.22

# Metabolic_Enzyme_4_SNPs:
rs11546155; rs3746452; rs2076668; rs6088624; rs8120670; rs17092148; rs1984588; rs6120742; rs11699070; rs6119535; rs6119534; rs6119536; rs6120748; rs7263157; rs17122844; rs6120747; rs7354108; rs11697978; rs11698977; rs761481; rs7273470; rs11696546; rs17092149; rs6087639; rs6120746; rs11698996; rs2064453; rs34687214; rs6060095; rs35006054; rs6060078; rs6060079; rs7266944; rs11546156; rs6060080; rs10666634; rs10611859; rs6060082; rs6060081; rs6060077; rs34381589; rs35511575; rs10527077; rs6058126; rs8183445; rs6058127; rs6120743; rs6060084; rs6060096; rs6060097; rs34384459; rs6088627; rs41290902; rs34124885; rs35181666; rs6060090; rs11476486; rs34277320; rs33912843; rs6060098; rs41290904; rs6058129; rs34961294; rs11907458; rs34086165; rs11907128; rs6058128; rs6060099; rs6088633; rs6087640; rs5841184; rs6058125; rs8120847; rs6058130; rs6060083; rs6060103; rs6141519; rs11472270; rs35393655; rs11387013; rs11699132; rs6088629; rs7265109; rs6088628; rs12151936; rs6120744; rs6142253; rs34178465; rs34930184; rs6058124; rs6058132; rs6088631; rs11357916; rs6088632; rs6060085; rs6060092; rs6088625; rs6060088; rs6060091; rs6060102; rs6088626; rs6119531; rs36084138; rs1013677; rs12625149; rs2295095; rs2295096; rs6060072; rs6060073; rs6060074; rs6087641; rs6088635; rs6088638; rs6119540; rs7269682

# Metabolic_Enzyme_4_General_References:
12270127; 12693554; 11780052

# Metabolic_Enzyme_4_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
6003

# Macromolecular_Interacting_Partner_1_Name:
Gamma-glutamyltransferase-like protein 2

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
GGT2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Gammaglutamyltransferaselike protein 2
MTSEFFAAQLRSQISDHTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYG
ILFNNEWTTSALPAFTNEFGAPPSPANFIQPGKQPLLSMCLTIMVGQDGQVRMVVGAAGG
TQITTDTALAIIYNLWFGYDVKRAVEEPRLHNKLLPNVTTVERNIDQAVTAALETRHHHT
QIASTFIAVVQAIVRTAGGWAAALDSRKGGEPAGY

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
215

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
23152

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.85

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring amino-acyl groups
Function:  gamma-glutamyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01019:G_glu_transpept

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
GGTL2_HUMAN (P36268)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
GGT2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
GGT2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:4251

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AP000550

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_1_Locus:
22q11.21|22q11.1

# Macromolecular_Interacting_Partner_1_SNPs:
rs3984302; rs1055042; rs8139086; rs8140378; rs5747777; rs12157499; rs243423; rs16984529; rs4619710; rs531659; rs458129; rs3984335; rs3984362; rs615918; rs585882; rs3095824; rs4627683; rs3984348; rs2416648; rs3984350; rs524221; rs3984344; rs675932; rs3984359; rs429047; rs419876; rs3984347; rs425672; rs5747781; rs243430; rs712972; rs3893047; rs365982; rs243428; rs243429; rs370606; rs243431; rs2080690; rs5993280; rs3984324; rs243424; rs5742550; rs4619711; rs4532045; rs5992267; rs243422; rs3984309; rs3984322; rs645912; rs5993253; rs12163291; rs9605723; rs5747772; rs5992265; rs3984304; rs5747745; rs5993279; rs7289002; rs5993283; rs3984317; rs2330839; rs28454543; rs3984310; rs645874; rs5993281; rs12163068; rs28484915; rs5747773; rs3984323; rs3984308; rs3984320; rs4482586; rs5742291; rs5746592; rs3984307; rs28457127; rs5992266; rs28570688; rs445155; rs3984318; rs5992264; rs3984383; rs3962704; rs1682970; rs5992258; rs5747768; rs634241; rs5993260; rs12172311; rs5992261; rs3865661; rs3984340; rs11703106; rs3984377; rs415866; rs3984396; rs592227; rs592678; rs3984356; rs28432349; rs4453774; rs3984341; rs5747771; rs3962702; rs5993262; rs5993274; rs28545002; rs376710; rs3984328; rs5746589; rs9605714; rs3984369; rs3984381; rs12160828; rs3984332; rs5747751; rs12172441; rs3984343; rs3984354; rs3984365; rs527127; rs5993268; rs3984331; rs416172; rs5992255; rs3962683; rs3984326; rs5747761; rs618606; rs2416647; rs2544149; rs491974; rs28373739; rs9617727; rs3984370; rs3984367; rs3984373; rs407014; rs5747770; rs3984351; rs9605713; rs3095770; rs3984333; rs3865660; rs3962699; rs3852971; rs5993257; rs12172257; rs9605715; rs521558; rs3984342; rs3984349; rs431943; rs3984368; rs3894040; rs3984375; rs3095823; rs4532044; rs416669; rs5993273; rs5992262; rs678219; rs388369; rs391221; rs5742290; rs3984361; rs5747747; rs3984363; rs5747750; rs3894042; rs12160575; rs5993263; rs28676434; rs604301; rs3984338; rs3896619; rs5747759; rs3962701; rs5742579; rs5992260; rs5747769; rs5747760; rs439131; rs3984329; rs9604865; rs3962700; rs563090; rs3894044; rs3984345; rs5993261; rs3962682; rs3984382; rs3984371; rs9605710; rs3984364; rs3984352; rs3984339; rs604353; rs3984327; rs5992257; rs2544148; rs5747762; rs5747754; rs407275; rs5993278; rs5993258; rs391231; rs492871; rs3984372; rs5747764; rs5747755; rs3984366; rs12172258; rs5993267; rs5747749; rs3875899; rs5992263; rs3962705; rs5993259; rs7510731; rs28661417; rs413929; rs5747779; rs364896; rs444912; rs4621252; rs4819722; rs9618341; rs847019; rs3984403; rs363963; rs5747780; rs370956; rs7510856; rs12163131; rs243427

# Macromolecular_Interacting_Partner_1_General_References:
10591208; 2573352

# Macromolecular_Interacting_Partner_1_References:
Not Available

End of HMDB00078

Beginning of HMDB00079
# Accession_No:
HMDB00079

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-14 12:14:20

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Dihydrothymine

# Description:
An intermediate breakdown product of thymine.  Dihydropyrimidine dehydrogenase catalyzes the reduction of thymine to 5, 6-dihydrothymine then dihydropyrimidinase hydrolyzes 5, 6-dihydrothymine to N-carbamyl-b-alanine. Finally, beta-ureidopropionase catalyzes the conversion of N-carbamyl-b-alanine to beta-alanine. Patients with dihydropyrimidinase deficiency exhibit highly increased concentrations of 5, 6-dihydrouracil and 5, 6-dihydrothymine and moderately increased concentrations of uracil and thymine can be detected in urine

# Synonyms:
5,6-Dihydro-5-methyluracil; 5,6-Dihydrothymine; 5-Methyl-5,6-dihydrouracil; 5-Methyldihydropyrimidine-2,4(1H,3H)-dione; 5-methyl-Hydrouracil; Dihydrothymine; dihydro-5-methyl-2,4(1H,3H)-Pyrimidinedione

# Chemical_IUPAC_Name:
5-methyl-1,3-diazinane-2,4-dione

# Chemical_Formula:
C5H8N2O2

# Chemical_Structure:
tbl_chemical:::HMDB00079_ZOOM.png:::119283178763254434

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00079_THUMB.png:::119283178605498784

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
carboxylic acid imide, N-unsubstituted; urea; heterocyclic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
128.05858

# Molecular_Weight_Avg:
128.12921

# Smiles_String_isomeric:
CC1CNC(=O)NC1=O

# Smiles_String_canonical:
CC1CNC(=O)NC1=O

# KEGG_Compound_ID:
C00906

# BioCyc_ID:
DIHYDRO-THYMINE

# PubChem_CID:
93556

# PubChem_SID:
10533089; 10327705; 10226060; 841370; 4316385; 670574; 4161; 98350; 7219204; 3223232; 8144506

# OMIM_ID:
222748; 251850; 274270

# Metagene_ID:
DIHYDROPYRIMIDINASE (DHPA): 410

# BiGG_ID:
36347

# Wikipedia_ID:
Not Available

# METLIN_ID:
5135

# Ref_ID:
9323563; 11106323; 12798197; 9860876; 9857238; 8615641; 9679586; 9714435

# ChEBI_ID:
27468

# CAS_Registry_Number:
696-04-8

# InChI:
InChI=1/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9)

# Synthesis_Reference:
A new method of selective photochemical reduction of uracil and thymine.     Yakovlev, D. Yu.; Khomutov, A. R.; Khomutov, R. M.    V. A. Engelkhardt Inst. Mol. Biol.,  Moscow,  USSR.    Bioorganicheskaya Khimiya  (1991),  17(6),  857-9.

# Melting_Point:
Not Available

# Melting_Point_predicted:
92.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
18.7 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-0.79 [Predicted by ALOGPS]; -0.9 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Dihydrothymine.mol:::1132723805578872101

# SDF_File_[Text]:
tbl_chemical:::HMDB00079.sdf:::119283178250921704

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00079.pdb:::119283178467882543

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::050126_P00_08_IS_1DP_Presat.png:::116475416564377788

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::050126_P00_08_IS_1DP_Presat.zip:::116475416565069117

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::050126_P00_08_IS_1DP_Assigned.png:::117511806067785732

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Dihydrothymine.gif:::1132732106296734600

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00079_peaks.txt:::1156309532771393177

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Dihydrothymine_C.gif:::11327376775065502

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00079_peaks.txt:::115631072311086196

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00079L.png:::117555262272617799; Medium Energy:tbl_ms:::HMDB00079M.png:::117555267529249057; High Energy:tbl_ms:::HMDB00079H.png:::117555271217411448

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Urine

# Concentration_[Normal]:
Urine	0.4	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	12798197
Urine	0.40 (0.17-0.64)	umol/mmol_creatinine	Adult:>18_yrs_old	Male	Normal	9857238
Urine	0.57 (0.21-0.94)	umol/mmol_creatinine	Adult:>18_yrs_old	Female	Normal	9857238


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Dihydropyrimidine dehydrogenase (DPD) deficiency; Dihydropyrimidinuria; Dihydropyrimidinuria (DHPuria)

# Pathway_Names:
Pantothenate and CoA biosynthesis

# Pathway_Images:
Not Available

# KEGG_Images:
map00770

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
6002

# Metabolic_Enzyme_1_Name:
Dihydropyrimidine dehydrogenase [NADP+] precursor

# Metabolic_Enzyme_1_Synonyms:
DPD; DHPDHase; Dihydrouracil dehydrogenase; Dihydrothymine dehydrogenase

# Metabolic_Enzyme_1_Gene_Name:
DPYD

# Metabolic_Enzyme_1_Protein_Sequence:
>Dihydropyrimidine dehydrogenase NADP+ precursor
MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFD
DIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDN
PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPE
KMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDV
VNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQD
QGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVF
IVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWN
EDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGG
DVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGL
KFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMY
GPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDS
GADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSI
ARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTS
IARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYL
KSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQ
NVAFSPLKRSCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCY
MTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLS
VNPVC

# Metabolic_Enzyme_1_Number_of_Residues:
1025

# Metabolic_Enzyme_1_Molecular_Weight:
111375

# Metabolic_Enzyme_1_Theoretical_pI:
7.05

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  disulfide oxidoreductase activity
Function:  dihydroorotate dehydrogenase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-CH group of donors
Function:  oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
Function:  dihydroorotate oxidase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  transporter activity
Function:  electron transporter activity
 ||
>>>
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  pyrimidine base metabolism
Process:  pyrimidine base biosynthesis
Process:  'de novo' pyrimidine base biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  membrane
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil

# Metabolic_Enzyme_1_Pathway:
map00240  Pyrimidine metabolism;
 map00410  beta-Alanine metabolism;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_1_Reaction:
5,6-dihydrouracil + NADP+ = uracil + NADPH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01180:DHO_dh;
PF00037:Fer4;
PF07992:Pyr_redox_2

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.3.1.2

# Metabolic_Enzyme_1_GenBank_ID_Protein:
558305

# Metabolic_Enzyme_1_SwissProt_ID:
DPYD_HUMAN (Q12882)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
DPYD

# Metabolic_Enzyme_1_Geneatlas_id:
DPYD

# Metabolic_Enzyme_1_hgnc_id:
HGNC:3012

# Metabolic_Enzyme_1_PDB_ID:
1GTE

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>3078 bp
ATGGCCCCTGTGCTCAGTAAGGACTCGGCGGACATCGAGAGTATCCTGGCTTTAAATCCT
CGAACACAAACTCATGCAACTCTGTGTTCCACTTCGGCCAAGAAATTAGACAAGAAACAT
TGGAAAAGAAATCCTGATAAGAACTGCTTTAATTGTGAGAAGCTGGAGAATAATTTTGAT
GACATCAAGCACACGACTCTTGGTGAGCGAGGAGCTCTCCGAGAAGCAATGAGATGCCTG
AAATGTGCAGATGCCCCGTGTCAGAAGAGCTGTCCAACTAATCTTGATATTAAATCATTC
ATCACAAGTATTGCAAACAAGAACTATTATGGAGCTGCTAAGATGATATTTTCTGACAAC
CCACTTGGTCTGACTTGTGGAATGGTATGTCCAACCTCTGATCTATGTGTAGGTGGATGC
AATTTATATGCCACTGAAGAGGGACCCATTAATATTGGTGGATTGCAGCAATTTGCTACT
GAGGTATTCAAAGCAATGAGTATCCCACAGATCAGAAATCCTTCGCTGCCTCCCCCAGAA
AAAATGTCTGAAGCCTATTCTGCAAAGATTGCTCTTTTTGGTGCTGGGCCTGCAAGTATA
AGTTGTGCTTCCTTTTTGGCTCGATTGGGGTACTCTGACATCACTATATTTGAAAAACAA
GAATATGTTGGTGGTTTAAGTACTTCTGAAATTCCTCAGTTCCGGCTGCCGTATGATGTA
GTGAATTTTGAGATTGAGCTAATGAAGGACCTTGGTGTAAAGATAATTTGCGGTAAAAGC
CTTTCAGTGAATGAAATGACTCTTAGCACTTTGAAAGAAAAAGGCTACAAAGCTGCTTTC
ATTGGAATAGGTTTGCCAGAACCCAATAAAGATGCCATCTTCCAAGGCCTGACGCAGGAC
CAGGGGTTTTATACATCCAAAGACTTTTTGCCACTTGTAGCCAAAGGCAGTAAAGCAGGA
ATGTGCGCCTGTCACTCTCCATTGCCATCGATACGGGGAGTCGTGATTGTACTTGGAGCT
GGAGACACTGCCTTCGACTGTGCAACATCTGCTCTACGTTGTGGAGCTCGCCGAGTGTTC
ATCGTCTTCAGAAAAGGCTTTGTTAATATAAGAGCTGTCCCTGAGGAGATGGAGCTTGCT
AAGGAAGAAAAGTGTGAATTTCTGCCATTCCTGTCCCCACGGAAGGTTATAGTAAAAGGT
GGGAGAATTGTTGCTATGCAGTTTGTTCGGACAGAGCAAGATGAAACTGGAAAATGGAAT
GAAGATGAAGATCAGATGGTCCATCTGAAAGCCGATGTGGTCATCAGTGCCTTTGGTTCA
GTTCTGAGTGATCCTAAAGTAAAAGAAGCCTTGAGCCCTATAAAATTTAACAGATGGGGT
CTCCCAGAAGTAGATCCAGAAACTATGCAAACTAGTGAAGCATGGGTATTTGCAGGTGGT
GATGTCGTTGGTTTGGCTAACACTACAGTGGAATCGGTGAATGATGGAAAGCAAGCTTCT
TGGTACATTCACAAATACGTACAGTCACAATATGGAGCTTCCGTTTCTGCCAAGCCTGAA
CTACCCCTCTTTTACACTCCTATTGATCTGGTGGACATTAGTGTAGAAATGGCCGGATTG
AAGTTTATAAATCCTTTTGGTCTTGCTAGCGCAACTCCAGCCACCAGCACATCAATGATT
CGAAGAGCTTTTGAAGCTGGATGGGGTTTTGCCCTCACCAAAACTTTCTCTCTTGATAAG
GACATTGTGACAAATGTTTCCCCCAGAATCATCCGGGGAACCACCTCTGGCCCCATGTAT
GGCCCTGGACAAAGCTCCTTTCTGAATATTGAGCTCATCAGTGAGAAAACGGCTGCATAT
TGGTGTCAAAGTGTCACTGAACTAAAGGCTGACTTCCCAGACAACATTGTGATTGCTAGC
ATTATGTGCAGTTACAATAAAAATGACTGGACGGAACTTGCCAAGAAGTCTGAGGATTCT
GGAGCAGATGCCCTGGAGTTAAATTTATCATGTCCACATGGCATGGGAGAAAGAGGAATG
GGCCTGGCCTGTGGGCAGGATCCAGAGCTGGTGCGGAACATCTGCCGCTGGGTTAGGCAA
GCTGTTCAGATTCCTTTTTTTGCCAAGCTGACCCCAAATGTCACTGATATTGTGAGCATC
GCAAGAGCTGCAAAGGAAGGTGGTGCCAATGGCGTTACAGCCACCAACACTGTCTCAGGT
CTGATGGGATTAAAATCTGATGGCACACCTTGGCCAGCAGTGGGGATTGCAAAGCGAACT
ACATATGGAGGAGTGTCTGGGACAGCAATCAGACCTATTGCTTTGAGAGCTGTGACCTCC
ATTGCTCGTGCTCTGCCTGGATTTCCCATTTTGGCTACTGGTGGAATTGACTCTGCTGAA
AGTGGTCTTCAGTTTCTCCATAGTGGTGCTTCCGTCCTCCAGGTATGCAGTGCCATTCAG
AATCAGGATTTCACTGTGATCGAAGACTACTGCACTGGCCTCAAAGCCCTGCTTTATCTG
AAAAGCATTGAAGAACTACAAGACTGGGATGGACAGAGTCCAGCTACTGTGAGTCACCAG
AAAGGGAAACCAGTTCCACGTATAGCTGAACTCATGGACAAGAAACTGCCAAGTTTTGGA
CCTTATCTGGAACAGCGCAAGAAAATCATAGCAGAAAACAAGATTAGACTGAAAGAACAA
AATGTAGCTTTTTCACCACTTAAGAGAAGCTGTTTTATCCCCAAAAGGCCTATTCCTACC
ATCAAGGATGTAATAGGAAAAGCACTGCAGTACCTTGGAACATTTGGTGAATTGAGCAAC
GTAGAGCAAGTTGTGGCTATGATTGATGAAGAAATGTGTATCAACTGTGGTAAATGCTAC
ATGACCTGTAATGATTCTGGCTACCAGGCTATACAGTTTGATCCAGAAACCCACCTGCCC
ACCATAACCGACACTTGTACAGGCTGTACTCTGTGTCTCAGTGTTTGCCCTATTGTCGAC
TGCATCAAAATGGTTTCCAGGACAACACCTTATGAACCAAAGAGAGGCGTACCCTTATCT
GTGAATCCGGTGTGTTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U09178

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_1_Locus:
1p22

# Metabolic_Enzyme_1_SNPs:
rs1801159; rs1801265; rs2297595; rs1801158; rs1801160; rs17376848; rs6670886; rs291593; rs1042482; rs291592; rs17470762; rs2786770; rs1556798; rs1760215; rs1520658; rs1889229; rs1974203; rs1337752; rs1333717; rs290853; rs2811186; rs2811218; rs1760217; rs2811184; rs828054; rs2027250; rs1931066; rs1556796; rs2811196; rs993714; rs1399285; rs2027056; rs2056048; rs1556795; rs1709409; rs1514494; rs2786775; rs1931063; rs1034217; rs290852; rs828052; rs576189; rs2786512; rs2039448; rs2811173; rs2105129; rs2811219; rs2786778; rs2811185; rs1974204; rs828053; rs2811182; rs1023245; rs1760209; rs494271; rs2786771; rs2297779; rs290855; rs1413235; rs666924; rs2786781; rs2056047; rs868184; rs865242; rs2811198; rs290807; rs11165784; rs1000391; rs4246515; rs6677502; rs4421623; rs495257; rs4582836; rs6697132; rs7531138; rs11165867; rs11799494; rs1413239; rs10875049; rs2811193; rs11165924; rs2811164; rs4970720; rs10493893; rs11165800; rs7526108; rs6681958; rs2039447; rs4554755; rs10875100; rs6670102; rs10157611; rs6671771; rs4304627; rs914959; rs6668296; rs6700670; rs7522938; rs1402258; rs2786518; rs2786776; rs11811087; rs6661442; rs1415681; rs533365; rs11165869; rs1112314; rs652246; rs2297780; rs11165875; rs11165804; rs1879375; rs3897933; rs6663357; rs6593635; rs628959; rs6692658; rs10875084; rs4128473; rs10875098; rs12119089; rs6668653; rs10875051; rs11165791; rs10430074; rs7519652; rs1333721; rs10875090; rs11165846; rs4451581; rs1514499; rs4379706; rs2786505; rs10875076; rs12564011; rs4970721; rs10747491; rs1413227; rs2137975; rs11165886; rs7516492; rs7539889; rs7541618; rs1023244; rs12122032; rs6675325; rs4949955; rs1931064; rs6663670; rs7555294; rs7548189; rs2811212; rs4523551; rs7537165; rs4353133; rs12039249; rs2786507; rs499009; rs526645; rs2811199; rs2248658; rs7412142; rs11165895; rs6665429; rs7512910; rs10875102; rs1413232; rs4495747; rs7527030; rs1538176; rs4970728; rs10875094; rs6700063; rs4950032; rs4319377; rs6604874; rs10747487; rs6700981; rs950467; rs6674636; rs1520664; rs1413231; rs4970716; rs528455; rs2811190; rs7525018; rs952856; rs4264037; rs7533902; rs10493894; rs827497; rs2786519; rs290851; rs7527272; rs7535694; rs991544; rs1337522; rs2811221; rs6593640; rs7540201; rs11165789; rs6667364; rs2027054; rs10518636; rs1999571; rs1890138; rs6593641; rs10783056; rs4503384; rs7520102; rs6687374; rs2027057; rs11165823; rs2811211; rs10875105; rs4950031; rs4300257; rs6656660; rs2811167; rs13375516; rs1556794; rs4497250; rs866129; rs4950025; rs1556797; rs970337; rs507170; rs2151563; rs7538155; rs4970723; rs4520446; rs1337521; rs4949952; rs552926; rs4970719; rs2811220; rs4537601; rs7552825; rs6593642; rs945879; rs667565; rs1333727; rs6593634; rs638456; rs1034215; rs2786494; rs6604094; rs9661794; rs11165922; rs2151567; rs6686861; rs11811436; rs1607778; rs11165783; rs4372296; rs10875085; rs519852; rs6668057; rs12566907; rs6593638; rs10875053; rs7523609; rs2786785; rs10783057; rs12568621; rs10735793; rs4511173; rs4390222; rs6681752; rs4950021; rs2786500; rs12030174; rs11165827; rs5027693; rs2786529; rs7517899; rs17100624; rs17378455; rs10518643; rs2786496; rs864341; rs1034216; rs6698780; rs6689930; rs12120077; rs4412640; rs2786509; rs12411169; rs17471640; rs12074083; rs9782950; rs4415625; rs10493895; rs2225882; rs12062845; rs10747486; rs17116810; rs10875118; rs11165923; rs10875055; rs17379561; rs10875075; rs17116566; rs4950041; rs4950033; rs2786543; rs993568; rs11165815; rs9727976; rs17369442; rs2811179; rs11165861; rs7530858; rs12402250; rs11808108; rs4546957; rs6672633; rs12040763; rs7538995; rs12024830; rs1413241; rs6685859; rs6604095; rs4414075; rs11165793; rs885622; rs17116720; rs10875069; rs10875073; rs17116602; rs12126093; rs17702702; rs11800171; rs4950023; rs11810136; rs10875113; rs955850; rs6667550; rs11165883; rs2786539; rs4394693; rs10783063; rs1333719; rs11165837; rs1577897; rs12073839; rs563832; rs12061124; rs4367807; rs12081472; rs17116539; rs10875056; rs1879373; rs6692424; rs4949947; rs7527085; rs10747488; rs10518637; rs644023; rs12729863; rs2151562; rs828059; rs12123121; rs4360558; rs12048767; rs2786498; rs2786490; rs17116531; rs11811238; rs7512040; rs17116806; rs11165921; rs652247; rs12021567; rs7518848; rs7519112; rs2811169; rs1413234; rs11805672; rs952501; rs10747484; rs11165845; rs2786514; rs10875071; rs4949953; rs17379095; rs914956; rs12047910; rs10875058; rs4589145; rs1538120; rs2152878; rs6683957; rs12063030; rs4950026; rs12124566; rs7517433; rs592609; rs12140120; rs1879371; rs2811202; rs6699630; rs2811194; rs17117003; rs2811171; rs1514496; rs11165873; rs12116905; rs2130365; rs11165798; rs693680; rs7554586; rs7522200; rs6678858; rs2811183; rs10783066; rs11165881; rs3790384; rs10875045; rs954923; rs1415682; rs11165864; rs7528359; rs2811209; rs17377638; rs2811177; rs1520660; rs12127420; rs1399291; rs11165870; rs493517; rs1577895; rs641805; rs3897854; rs12136186; rs9662870; rs12093067; rs4949958; rs676686; rs595937; rs1413229; rs10875109; rs6604092; rs9661407; rs6672867; rs6692580; rs2811205; rs6700920; rs6593647; rs10493892; rs2811187; rs2065943; rs1879374; rs11165814; rs6593633; rs1915313; rs11582955; rs945881; rs7544742; rs1000392; rs471581; rs12062552; rs12130586; rs2811215; rs3790389; rs2811192; rs17116766; rs10783069; rs6703307; rs1760212; rs553388; rs13376217; rs2786533; rs11165889; rs12407793; rs2811208; rs12735722; rs16798; rs10783058; rs2786773; rs1520663; rs10493890; rs2786782; rs11165874; rs12563828; rs7523632; rs6682836; rs10157665; rs3762412; rs6676451; rs10493896; rs2786538; rs4246514; rs11582179; rs1356919; rs4394694; rs12024396; rs2786525; rs1333718; rs2786522; rs12023630; rs10747482; rs11799399; rs644428; rs7530072; rs10747492; rs10875057; rs7521383; rs10875061; rs4492658; rs12129287; rs4128472; rs8179310; rs11165902; rs12406000; rs7540983; rs6681743; rs4304628; rs1931071; rs2811174; rs11165792; rs11589238; rs6677116; rs12407440; rs11165794; rs2786503; rs2811162; rs12022771; rs7544128; rs11165799; rs12031561; rs12059052; rs10875048; rs7513333; rs10875046; rs2780851; rs1415683; rs2056049; rs2811168; rs12041436; rs11165830; rs11812084; rs6604119; rs2811200; rs12119882; rs9437663; rs867261; rs7526691; rs11165863; rs11806109; rs6664888; rs2786537; rs2786504; rs6683351; rs11578795; rs11802430; rs7545712; rs10783065; rs7556439; rs7537668; rs11587873; rs10875077; rs11165877; rs6593636; rs9662719; rs864335; rs11165856; rs11588048; rs1014320; rs11805694; rs2095686; rs7524038; rs7516781; rs17116469; rs10875112; rs11165829; rs17116860; rs11165797; rs2027055; rs950754; rs496179; rs1520668; rs10875050; rs11165779; rs10875074; rs10875064; rs10047165; rs828058; rs2090763; rs12568335; rs10747485; rs7516433; rs10875062; rs1514497; rs6696033; rs10465748; rs4348763; rs12097618; rs2811165; rs11165908; rs1609519; rs11165855; rs11165887; rs2811203; rs1879372; rs2184191; rs9725545; rs11165879; rs2811170; rs12040388; rs7545340; rs2811195; rs10875099; rs1337523; rs1514495; rs6685976; rs12354219; rs7550959; rs12566576; rs6697058; rs17117234; rs7523116; rs1399290; rs11165880; rs1333722; rs6593639; rs6684683; rs11165888; rs3897932; rs7549522; rs11810126; rs7549384; rs12134028; rs12081878; rs2786530; rs7521757; rs12032158; rs12567359; rs12022243; rs12089031; rs12044858; rs2018605; rs10875111; rs12760992; rs4970717; rs10875060; rs2485436; rs4950028; rs6593650; rs11580981; rs2811204; rs11806147; rs12752069; rs12746909; rs17370884; rs6593646; rs12759852; rs12073005; rs17117211; rs1413224; rs2811161; rs17117281; rs12565248; rs828057; rs2811214; rs12129397; rs11799497; rs11165802; rs4266934; rs7522113; rs542490; rs10465760; rs6701415; rs12090036; rs17116502; rs12048428; rs7531100; rs12086529; rs12029106; rs12731506; rs17116925; rs7528631; rs17117194; rs12084600; rs7547060; rs6682669; rs945880; rs12133566; rs2786540; rs12564608; rs10783076; rs4434871; rs6663628; rs10783060; rs17377919; rs2811213; rs12025602; rs2991263; rs4949949; rs12066229; rs10783055; rs7524812; rs17378539; rs7418577; rs6702893; rs6702924; rs2811216; rs1931072; rs2152877; rs6661380; rs11165822; rs2786783; rs12034649; rs10875089; rs2786502; rs17117037; rs17116439; rs17116909; rs12030316; rs17117251; rs7520949; rs2811163; rs10875106; rs6593649; rs10875070; rs11165891; rs6593648; rs17116962; rs7549538; rs13375850; rs11809950; rs2811210; rs17431828; rs12063370; rs3790387; rs17116452; rs7527411; rs4949950; rs10875095; rs10458511; rs7542014; rs12060037; rs7554746; rs2811191; rs10747483; rs12043044; rs10875080; rs12139650; rs17117198; rs12127542; rs4950037; rs12059591; rs12060207; rs12725266; rs11165926; rs17117179; rs11165835; rs11165903; rs9725575; rs12094393; rs6690620; rs12063966; rs11801171; rs12123145; rs17116821; rs7529372; rs4970727; rs12048063; rs4950035; rs12073650; rs12564297; rs12124552; rs17471125; rs6682655; rs7528037; rs12091654; rs290850; rs7512213; rs6691128; rs17369919; rs2786497; rs12048612; rs13373839; rs4399192; rs7536690; rs1399287; rs7545029; rs17117181; rs12079743; rs12047625; rs7511709; rs7514826; rs1040090; rs914937; rs2786777; rs4266922; rs6664275; rs11165884; rs12043021; rs6604093; rs6686280; rs2039449; rs12568733; rs7556387; rs11799304; rs17117062; rs1356917; rs563033; rs10875052; rs12046744; rs2811201; rs12048663; rs6683883; rs505864; rs5027690; rs2786780; rs6698789; rs11589971; rs12403187; rs7537094; rs17117169; rs12079660; rs17471577; rs7554113; rs10449723; rs11165917; rs12060434; rs4612663; rs7544620; rs17117173; rs10735795; rs11165862; rs12758854; rs11165786; rs17117203; rs12094181; rs7550523; rs6656968; rs7414298; rs6703589; rs12756513; rs17368985; rs11586728; rs12022799; rs12731707; rs11590802; rs6686712; rs11588242; rs10875047; rs4949945; rs6693628; rs12091152; rs1413230; rs6593631; rs1399289; rs6676635; rs6593637; rs12401348; rs17117162; rs12128564; rs2786532; rs17117052; rs11165810; rs7546038; rs2786526; rs12121057; rs17117159; rs7543523; rs2811188; rs3897855; rs4497251; rs17116518; rs2786772; rs6684671; rs17117175; rs11165831; rs885086; rs17378671; rs12077442; rs12354275; rs10465749; rs6688509; rs12081900; rs7411676; rs2811181; rs12032276; rs12740796; rs1889228; rs7521567; rs4970715; rs6685266; rs11165857; rs6689552; rs12047072; rs4950042; rs17117116; rs11578528; rs7529624; rs12096383; rs10747494; rs12403912; rs2811178; rs4950030; rs12086531; rs1013810; rs12137174; rs9727974; rs6593643; rs12035560; rs12080739; rs4950040; rs12406752; rs2811166; rs1333728; rs6692877; rs827500; rs4350235; rs11165826; rs28595744; rs9324374; rs3920740; rs10783070; rs7527288; rs6674158; rs10218636; rs7551099; rs11165807; rs4351704; rs12028211; rs2786521; rs11165788; rs6696976; rs12409761; rs6667128; rs6604873; rs12049622; rs4290093; rs983101; rs6656329; rs10875119; rs12117481; rs17100628; rs2786508; rs9727548; rs11165925; rs17116479; rs9783115; rs12408270; rs10458510; rs12082644; rs6691764; rs7535930; rs6693964; rs2391822; rs10783062; rs12026902; rs12072735; rs17116465; rs11165882; rs12043043; rs11805551; rs2049110; rs7539477; rs12082185; rs11165832; rs6701322; rs7552188; rs2786542; rs2786769; rs11165860; rs1889230; rs828061; rs6692785; rs6421757; rs10783068; rs17117249; rs2786491; rs7540621; rs17116398; rs6692946; rs7521671; rs7515904; rs290808; rs11165912; rs2171826; rs12410949; rs12069661; rs7518354; rs2095663; rs1810252; rs11165781; rs2786501; rs12035468; rs12060391; rs4445510; rs11165900; rs11804848; rs12093238; rs7512357; rs4364915; rs2039676; rs12120068; rs7414210; rs12120388; rs6681394; rs290849; rs11165897; rs6593630; rs12563974; rs3120632; rs17116410; rs12043040; rs12139338; rs12043125; rs6680180; rs12407539; rs11165838; rs12753487; rs10783077; rs7527309; rs17368837; rs12735738; rs6685658; rs11165866; rs12073044; rs13376084; rs4634942; rs12122798; rs11588741; rs17116476; rs11812070; rs12137711; rs12126850; rs4949951; rs1970143; rs1889227; rs6680642; rs11165805; rs11584924; rs17117112; rs828060; rs7514861; rs828063; rs12082798; rs7555984; rs12064659; rs12023626; rs2786536; rs10747489; rs17117167; rs7521352; rs7521541; rs11165834; rs11583545; rs6691565; rs12406631; rs6690403; rs2786541; rs17116940; rs9969993; rs290806; rs17117214; rs12033263; rs1760210; rs2786531; rs7546862; rs12144395; rs12141657; rs12046655; rs12136135; rs17117207; rs12026223; rs17116416; rs10747490; rs17116462; rs4970718; rs12081166; rs4427441; rs10875078; rs12087910; rs640711; rs12062102; rs10875088; rs4428925; rs828055; rs11165899; rs10875086; rs11165803; rs7543614; rs12740800; rs12403515; rs12133667; rs6672095; rs10465747; rs7545622; rs11811222; rs17116488; rs17117222; rs6660936; rs1413228; rs1963206; rs17116594; rs12402646; rs4385755; rs1333720; rs12086001; rs12032384; rs11165844; rs12074030; rs4949954; rs12124488; rs6690447; rs4329543; rs11165868; rs10875103; rs11165836; rs7544948; rs10875059; rs2811197; rs1577896; rs11587447; rs13375275; rs12040045; rs2786535; rs7526933; rs11582587; rs12725934; rs12119333; rs12076846; rs7537617; rs17116854; rs1812389; rs12134860; rs12068789; rs11165780; rs6658412; rs10875108; rs1931065; rs12735808; rs12759539; rs12726453; rs12066847; rs17116920; rs1117019; rs17116357; rs2018902; rs2811217; rs12040699; rs10127817; rs10158174; rs17116458; rs12092177; rs2811176; rs17117118; rs10875079; rs2068642; rs1399288; rs17117228; rs12565244; rs12125423; rs10875097; rs10875087; rs2786499; rs12144462; rs11165850; rs993921; rs12406713; rs7554218; rs11165920; rs11165790; rs12403997; rs9659958; rs4523552; rs6700957; rs17116506; rs17116509; rs28483122; rs1610253; rs6672654; rs12028565; rs12038518; rs7531326; rs12046771; rs10875091; rs2786506; rs6695791; rs11165865; rs2786513; rs12057205; rs9651211; rs12048413; rs12119381; rs6676351; rs12565467; rs7523775; rs11582736; rs12133176; rs10783059; rs12407546; rs12564345; rs2786544; rs12063497; rs10875092; rs12122422; rs6679142; rs12405810; rs6657204; rs7412024; rs689001; rs12089969; rs1413233; rs4319378; rs2786527; rs6676624; rs6690816; rs2811206; rs12739159; rs12068454; rs11583737; rs2786784; rs6679536; rs17432093; rs4970722; rs17117218; rs7545506; rs17117176; rs12059341; rs12040478; rs17117092; rs2786774; rs6593632; rs12047563; rs7525922; rs12567477; rs12045999; rs7553943; rs17117236; rs1855376; rs11165872; rs9727008; rs11580977; rs17432999; rs4950038; rs12093651; rs12094781; rs7521537; rs12125127; rs12039093; rs12047456; rs7531819; rs290861; rs158634; rs291550; rs17430460; rs6604096; rs1801267; rs1801266; rs1801268; rs3918289; rs6675198; rs1042478; rs1042479; rs3918290; rs34856860; rs1042481; rs41285690; rs1042480; rs2635723; rs34749842; rs28711209; rs4285753; rs35346681; rs4350236; rs28468570; rs1976175; rs28390368; rs12749253; rs12741091; rs12074340; rs11165849; rs35669577; rs5026209; rs35127872; rs11305940; rs36051564; rs12032753; rs34467104; rs35113568; rs5776346; rs12748804; rs33967766; rs7543832; rs11329199; rs34003262; rs9701777; rs36060250; rs3075432; rs9728815; rs5018206; rs35514561; rs35010383; rs12726496; rs34693701; rs3050245; rs4457618; rs35425120; rs36118685; rs11329805; rs3075442; rs12759500; rs35214370; rs10595002; rs12097480; rs34165549; rs34535802; rs12082772; rs34765667; rs35741625; rs10158970; rs7414112; rs11392740; rs12723967; rs828056; rs5776386; rs12746260; rs35040585; rs28755414; rs1015828; rs34965803; rs5776388; rs12072437; rs34433374; rs12745877; rs28699374; rs35005021; rs5776365; rs12093539; rs35192169; rs7543510; rs2780852; rs12092946; rs10449720; rs11350065; rs12089025; rs28422942; rs10783061; rs2256807; rs12142437; rs7512345; rs35583828; rs12736528; rs12066470; rs12083975; rs4638160; rs2786520; rs10615198; rs4411156; rs7521763; rs12754025; rs35538411; rs1356918; rs5776360; rs10875093; rs11432017; rs34586145; rs34541619; rs12567802; rs1855363; rs12116548; rs6689341; rs34145094; rs12081421; rs35173224; rs35656329; rs7547835; rs11366600; rs12033002; rs7415016; rs2811172; rs2222327; rs5027691; rs28514964; rs11582635; rs12091767; rs10783067; rs28880911; rs34314829; rs35183951; rs35854736; rs34602285; rs9727438; rs28552528; rs6682855; rs1958946; rs12752059; rs35025181; rs34091738; rs34894805; rs34185079; rs12755039; rs7538663; rs2786492; rs28829687; rs12078571; rs35863255; rs12041525; rs34113502; rs4504944; rs28615803; rs12030189; rs1413237; rs35330951; rs5776363; rs28755787; rs6687856; rs10606435; rs11338222; rs12141326; rs36076494; rs28478258; rs35515993; rs7517110; rs12136315; rs11165782; rs34754374; rs4565769; rs1970142; rs3765175; rs12134522; rs12029380; rs34380072; rs34875839; rs10674615; rs35316575; rs11404497; rs12089260; rs34047559; rs11801116; rs12737967; rs35717955; rs35151553; rs36153065; rs34486662; rs7519351; rs36074078; rs12138677; rs35967105; rs6669422; rs11382165; rs34683254; rs28538108; rs17116413; rs34791837; rs6663751; rs5776344; rs12057755; rs35605856; rs12024103; rs12140043; rs35905725; rs1856159; rs7524482; rs10157336; rs6676657; rs35413950; rs12095939; rs36194219; rs11801312; rs34463725; rs4495745; rs34613852; rs1798737; rs35441721; rs12073487; rs5776353; rs35924442; rs7539913; rs35398836; rs35459584; rs35970691; rs12029826; rs12745512; rs5776371; rs5776362; rs11582697; rs34087876; rs34267648; rs34328197; rs827498; rs12071499; rs35720876; rs35963307; rs35581369; rs34057124; rs5776356; rs34031151; rs34806595; rs7513650; rs11275458; rs10671966; rs28556633; rs12739046; rs13376487; rs12731376; rs34338692; rs35506398; rs34683131; rs9629025; rs12742215; rs12121789; rs2786524; rs28830194; rs35038074; rs12070513; rs36103731; rs2786523; rs12043033; rs12403951; rs5027664; rs7547044; rs28655439; rs12034568; rs12072104; rs35282661; rs472777; rs12031326; rs35531075; rs35764066; rs1984091; rs12022140; rs10637837; rs34445661; rs12022983; rs35975305; rs12137205; rs7513298; rs34054873; rs35415616; rs7530645; rs4970724; rs12756004; rs12119653; rs12759823; rs35692930; rs34379051; rs11165913; rs5776378; rs2151560; rs12746053; rs35752036; rs28671479; rs11589300; rs35568022; rs34528376; rs10677535; rs36025579; rs34654520; rs11430221; rs8179344; rs34950626; rs35933841; rs7553888; rs33972983; rs12071429; rs35566734; rs35893611; rs35613600; rs35692540; rs10591961; rs7553077; rs6143333; rs12729191; rs34452925; rs35684876; rs7552708; rs34830547; rs3790385; rs3862912; rs12567804; rs35146139; rs11165914; rs34671804; rs12066332; rs12086534; rs12090721; rs34765055; rs35253410; rs28613692; rs7516576; rs17377093; rs35308807; rs35339301; rs12088402; rs34563253; rs12134462; rs34305248; rs12040059; rs11165777; rs12727481; rs28558822; rs12738892; rs12064815; rs2811175; rs12044501; rs1607779; rs12143861; rs17116957; rs34747848; rs4285754; rs35469949; rs35693384; rs12041906; rs7411982; rs4558029; rs34985601; rs11165828; rs6681582; rs34678676; rs34960511; rs10567915; rs36000256; rs6679873; rs1760219; rs34192622; rs34311587; rs34454297; rs12061986; rs6689296; rs5029789; rs17117078; rs34215854; rs12076346; rs12184251; rs36090056; rs34738275; rs34686468; rs35406401; rs12093470; rs290854; rs41300337; rs36011197; rs34447969; rs9727787; rs6699098; rs28408889; rs35298859; rs35593702; rs11300172; rs34776985; rs12750553; rs11445699; rs9728796; rs571444; rs17116949; rs1360675; rs35163134; rs36017006; rs11165893; rs12730080; rs35900828; rs12758423; rs10702051; rs35825151; rs11586231; rs12071081; rs1212191; rs28526496; rs5776364; rs12126921; rs35271365; rs12044876; rs6666129; rs34098309; rs12087430; rs35463548; rs12038195; rs7418580; rs35643569; rs5776369; rs12074451; rs34535138; rs36040504; rs2786534; rs12408135; rs6667213; rs29001643; rs12034670; rs34055744; rs34380136; rs34198280; rs35054503; rs7515966; rs35687782; rs1113699; rs10672791; rs34460898; rs4351706; rs34387885; rs35767735; rs36037675; rs11310786; rs12137247; rs6663414; rs28452204; rs34853678; rs36060421; rs4615876; rs10631564; rs35274548; rs11576351; rs6665022; rs12026229; rs12024715; rs12032674; rs5776359; rs4431878; rs12757590; rs5776358; rs17370607; rs36108874; rs2203981; rs34346385; rs12758055; rs11349223; rs868185; rs35824060; rs36024354; rs1040091; rs34523862; rs11808750; rs28629820; rs12044783; rs12731596; rs12731834; rs12065693; rs35541962; rs34911421; rs7411984; rs35419371; rs11334243; rs17377142; rs28423050; rs4146964; rs6687950; rs11422049; rs12026200; rs12568554; rs1599778; rs12023030; rs10875054; rs28532649; rs34891420; rs4579796; rs12139679; rs36089455; rs35671365; rs12750100; rs34258528; rs10601085; rs12145481; rs11165854; rs11165928; rs10591187; rs12744789; rs13374282; rs34519857; rs7524759; rs12093707; rs35422302; rs5776384; rs36028550; rs9725886; rs35627404; rs1855378; rs12735483; rs35155457; rs34601540; rs4128720; rs13375858; rs2811207; rs35544114; rs4375301; rs13375021; rs34455783; rs12738234; rs12047930; rs34580383; rs12043147; rs12145460; rs36061783; rs34823012; rs673989; rs34290889; rs34553460; rs35189712; rs6143335; rs12753135; rs34011849; rs34224428; rs35050339; rs34390188; rs5776348; rs35495081; rs12724889; rs35346742; rs12029801; rs12141897; rs35432274; rs12048947; rs34312119; rs4445524; rs1402256; rs3921368; rs11414362; rs2485437; rs34034090; rs10651231; rs12081769; rs12058656; rs10622783; rs36025346; rs34270736; rs36081268; rs34150735; rs10449721; rs7526790; rs12042544; rs35864097; rs35707097; rs2786510; rs10616443; rs12043234; rs11165919; rs4428924; rs35605550; rs2786493; rs4570451; rs10545599; rs41313397; rs28627833; rs34653351; rs11165851; rs1337750; rs12726192; rs17599509; rs2786528; rs36024641; rs13376369; rs1514498; rs12727629; rs12136249; rs34547572; rs12041802; rs10565495; rs12408678; rs17117047; rs11286049; rs12725967; rs28696953; rs10617327; rs12749890; rs34844802; rs35635672; rs1709411; rs34428152; rs11366169; rs12128363; rs34774035; rs35453402; rs12751479; rs10158124; rs5027688; rs17116954; rs35422608; rs28514726; rs11428644; rs35471205; rs11333229; rs828062; rs35046170; rs34985058; rs35688762; rs11165909; rs2151564; rs34932777; rs1538175; rs12760243; rs12046043; rs17117044; rs10158132; rs35002871; rs34931312; rs35589952; rs35558163; rs35263335; rs34817211; rs6675639; rs35614335; rs34044808; rs12749862; rs11457319; rs35044029; rs36058943; rs6682166; rs12034814; rs827499; rs12097874; rs34788656; rs12131043; rs36148675; rs28455005; rs5776366; rs3050227; rs12756826; rs12070583; rs7410810; rs12402535; rs11165852; rs35210810; rs12047716; rs7411713; rs12023004; rs4336888; rs35675942; rs35131461; rs35608307; rs2151561; rs12030332; rs1984090; rs35220719; rs12751069; rs10625722; rs6674056; rs35309171; rs35070715; rs6678229; rs993569; rs34798489; rs10610591; rs35011266; rs6703357; rs34277796; rs11375210; rs34606787; rs34267374; rs28714464; rs12144123; rs12072154; rs28589864; rs35013990; rs4489611; rs34902826; rs12025217; rs5776387; rs35739503; rs34933007; rs12727975; rs10572395; rs12726516; rs12736531; rs35454049; rs34997220; rs12049600; rs35459236; rs35685115; rs34534958; rs34267012; rs35677459; rs35182755; rs12069330; rs7413448; rs34884630; rs17377205; rs7412430; rs35505267; rs2786511; rs34898972; rs12754968; rs12024083; rs34833945; rs35847147; rs7536770; rs10647561; rs1337751; rs5776385; rs34521601; rs11165894; rs34998323; rs12743854; rs12060079; rs35562854; rs10657499; rs35792674; rs5776352; rs35564684; rs12096724; rs9324375; rs4950029; rs34973099; rs34934403; rs12137138; rs12071338; rs2786495; rs12726688; rs9970119; rs12749069; rs11400594; rs34856977; rs34441398; rs12120514; rs4309016; rs12044838; rs34749427; rs12037001; rs11457298; rs11345923; rs2893373; rs6694335; rs35927808; rs3050223; rs35302041; rs4492671; rs34870370; rs34389018; rs12039808; rs35940342; rs35926262; rs35829715; rs12024660; rs4309030; rs4381229; rs12750717; rs12132383; rs12030792; rs34357448; rs34286411; rs28371444; rs34634453; rs7413375; rs35099417; rs28889402; rs2184969; rs12750549; rs34953224; rs34448971; rs34260541; rs3899778; rs7534056; rs34756596; rs5776377; rs35444260; rs35331418; rs7533929; rs601149; rs12032698; rs12027034; rs12058898; rs12139110; rs34230085; rs35815272; rs12739965; rs28692740; rs11165927; rs11165905; rs35322606; rs36134825; rs4514272; rs33986674; rs1589344; rs7513888; rs12043951; rs13376404; rs17116923; rs7543999; rs28436624; rs12138657; rs7411549; rs28848627; rs35251009; rs2210616; rs34146034; rs10666387; rs1589342; rs12075750; rs4950034; rs4408184; rs7548444; rs12750322; rs12064809; rs35491393; rs5776379; rs34244040; rs12067602; rs35506209; rs35658487; rs12024658; rs36173435; rs28623242; rs4543837; rs35399577; rs34892116; rs11165876; rs34843163; rs2049112; rs34606545; rs34002532; rs35302625; rs5776357; rs12760860; rs12024690; rs5776380; rs34736058; rs12406531; rs35699704; rs4259713; rs12750443; rs12048588; rs35060117; rs35671414; rs10689805; rs12094465; rs34230880; rs12742911; rs35378905; rs3790388; rs3956688; rs35222149; rs34650886; rs28552810; rs1413236; rs12739758; rs10783075; rs34169534; rs35212725; rs34719218; rs35923854; rs35301486; rs33994522; rs2786517; rs6604118; rs6656043; rs12032746; rs12027570; rs35856817; rs10158390; rs12734780; rs28457754; rs6702673; rs35402669; rs17116564; rs10558704; rs4572003; rs12072522; rs34631796; rs12735471; rs35441763; rs35686429; rs28490531; rs12022669; rs28428772; rs34338799; rs1856158; rs5015353; rs5776345; rs35477668; rs34405549; rs10430076; rs35488985; rs34146407; rs6693034; rs10430075; rs35371362; rs17369773; rs12032827; rs34638169; rs35748881; rs10642839; rs28590328; rs12045127; rs12744161; rs12410240; rs35504747; rs34806815; rs34084132; rs36042282; rs12750863; rs6683233; rs12138709; rs34773620; rs12046864; rs34210396; rs34000126; rs35063793; rs5776347; rs10157396; rs2786516; rs34394222; rs12406052; rs6666920; rs35216070; rs34698824; rs10157130; rs35786435; rs12741841; rs10564140; rs2786515; rs34213322; rs12096100; rs12751038; rs12091480; rs34250792; rs35947403; rs34486749; rs33998382; rs34397017; rs4363450; rs12408679; rs12047569; rs12072739; rs35694562; rs12093141; rs35181732; rs1970141; rs34401391; rs12090947; rs6674116; rs6678008; rs35856948; rs2152879; rs9727803; rs12024708; rs12745124; rs12042394; rs12133824; rs12086537; rs628816; rs4949944; rs36087444; rs885621; rs12727657; rs34992328; rs3075433; rs34096860; rs35012523; rs11408866; rs36005573; rs12080469; rs11343500; rs12035814; rs34407579; rs12144202; rs11165907; rs34583509; rs34002705; rs11165808; rs12749836; rs35475712; rs28363717; rs12567803; rs12032933; rs5015354; rs34863394; rs34704297; rs12751902; rs12091552; rs6673282; rs10719278; rs34085458; rs1931062; rs34457110; rs12410593; rs4128474; rs34092675; rs12048941; rs35732009; rs12125748; rs35070194; rs34516612; rs1399286; rs12758564; rs35729111; rs7528701; rs11442543; rs11337033; rs12036730; rs34511350; rs28503944; rs12043428; rs34132621; rs3790386; rs3050226; rs35417363; rs35740888; rs35592236; rs12042451; rs844144; rs10593660; rs35045109; rs12135891; rs34961061; rs35061265; rs35805795; rs2786489; rs35294947; rs34934786; rs34588073; rs11165915; rs12728798; rs5776361; rs11423158; rs688913; rs4604729; rs11374387; rs1589343; rs12727631; rs11406485; rs6143334; rs17368930; rs35600758; rs35728010; rs34833638; rs34754839; rs12029685; rs10218605; rs6657627; rs35795641; rs11584267; rs12022341; rs5776343; rs4112180; rs3790383; rs35169685; rs12727612; rs10449722; rs34186134; rs12738091; rs6676439; rs10607579; rs35748583; rs34699023; rs6670376; rs28619552; rs12077606; rs11165901; rs36082321; rs12091061; rs1212973; rs1413238; rs35742020; rs6661755; rs12045421; rs12750945; rs5776381; rs11165833; rs34993104; rs35349839; rs34513531; rs36079385; rs35917752; rs35946428; rs35738469; rs828051; rs35433813; rs12058771; rs34734647; rs11165918; rs36106303; rs12745144; rs35068907; rs12085788; rs6689165; rs11165806; rs35375213; rs33995723; rs478741; rs34374142; rs10685111; rs34749066; rs6692657; rs35192579; rs34449409; rs35500519; rs34942284; rs11379961; rs4950020; rs12753126; rs34035833; rs34656878; rs1202854; rs34256325; rs12088567; rs35729590; rs12406482; rs35917998; rs6696988; rs35745646; rs4612662; rs10598574; rs12734766; rs35718889; rs12094442; rs12039647; rs35519081; rs11590340; rs12564826; rs12033517; rs1337749; rs34455463; rs34343325; rs7514934; rs34476211; rs12752057; rs12136549; rs12402806; rs7414031; rs34581949; rs12078940; rs35518649; rs5027689; rs12040079; rs12732180; rs2786779; rs34154901; rs35691382; rs13374102; rs6671569; rs5776351; rs11165871; rs34754458; rs12752763; rs2245907; rs35474273; rs35814910; rs12126526; rs35740907; rs35111926; rs4950027; rs34805777; rs34786009; rs11165795; rs35231733; rs12733572; rs12410232; rs35303001; rs34597038; rs12736583; rs10645994; rs6659732; rs11580684; rs1009462; rs5776383; rs10681575; rs11434465; rs10572396; rs28796973; rs34389483; rs34059745; rs41309171; rs6668162; rs34435288; rs650879; rs12076723; rs1212190; rs34940186; rs36122057; rs35877260; rs2203982; rs34437573; rs28571585; rs12043146; rs35804789; rs1855364; rs35519928; rs35920443; rs2811180; rs35619235; rs35850346; rs5776349; rs4269803; rs34399548; rs34858264; rs290862; rs11165775; rs11800908; rs11807548; rs12028914; rs158635; rs17100610; rs1760216; rs290863; rs290865; rs290866; rs290867; rs290868; rs290869; rs35196212; rs4378243; rs4456128; rs7556646

# Metabolic_Enzyme_1_General_References:
8083224; 9135003; 9464498; 8892022; 9170156; 1512248; 9439663; 9266349

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5814

# Metabolic_Enzyme_2_Name:
Dihydropyrimidinase

# Metabolic_Enzyme_2_Synonyms:
DHPase; Hydantoinase; DHP

# Metabolic_Enzyme_2_Gene_Name:
DPYS

# Metabolic_Enzyme_2_Protein_Sequence:
>Dihydropyrimidinase
MAAPSRLLIRGGRVVNDDFSEVADVLVEDGVVRALGHDLLPPGGAPAGLRVLDAAGKLVL
PGGIDTHTHMQFPFMGSRSIDDFHQGTKAALSGGTTMIIDFAIPQKGGSLIEAFETWRSW
ADPKVCCDYSLHVAVTWWSDQVKEEMKILVQDKGVNSFKMFMAYKDLYMVTDLELYEAFS
RCKEIGAIAQVHAENGDLIAEGAKKMLALGITGPEGHELCRPEAVEAEATLRAITIASAV
NCPLYIVHVMSKSAAKVIADARRDGKVVYGEPIAASLGTDGTHYWNKEWHHAAHHVMGPP
LRPDPSTPDFLMNLLANDDLTTTGTDNCTFNTCQKALGKDDFTKIPNGVNGVEDRMSVIW
EKGVHSGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIVIWDPKGTRTISAKTHH
QAVNFNIFEGMVCHGVPLVTISRGKVVYEAGVFSVTAGDGKFIPRKPFAEYIYKRIKQRD
RTCTPTPVERAPYKGEVATLKSRVTKEDATAGTRKQAHP

# Metabolic_Enzyme_2_Number_of_Residues:
519

# Metabolic_Enzyme_2_Molecular_Weight:
56630

# Metabolic_Enzyme_2_Theoretical_pI:
7.28

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
5,6-dihydrouracil + H(2)O = 3- ureidopropanoate

# Metabolic_Enzyme_2_Pathway:
map00240  Pyrimidine metabolism;
 map00410  beta-Alanine metabolism;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_2_Reaction:
5,6-dihydrouracil + H2O = 3-ureidopropanoate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01979:Amidohydro_1

# Metabolic_Enzyme_2_Signals:
1-2

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.5.2.2

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1330236

# Metabolic_Enzyme_2_SwissProt_ID:
DPYS_HUMAN (Q14117)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
DPYS

# Metabolic_Enzyme_2_Geneatlas_id:
DPYS

# Metabolic_Enzyme_2_hgnc_id:
HGNC:3013

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_2_Gene_Sequence:
>1560 bp
ATGGCGGCGCCCTCGCGGCTCCTGATCCGCGGGGGTCGCGTGGTCAACGATGACTTCTCG
GAGGTGGCCGACGTGCTGGTGGAGGACGGCGTGGTGCGGGCACTCGGGCACGACCTGCTG
CCTCCCGGGGGCGCTCCTGCGGGGCTGCGGGTCCTCGACGCCGCCGGCAAGCTCGTCCTG
CCCGGAGGCATCGACACACACACGCACATGCAGTTCCCCTTCATGGGCTCGCGGTCCATC
GACGACTTCCACCAGGGCACCAAGGCTGCTCTCTCAGGAGGCACCACCATGATTATTGAT
TTCGCCATTCCTCAGAAAGGTGGCTCCCTCATTGAGGCCTTCGAGACCTGGCGAAGCTGG
GCTGATCCCAAAGTTTGCTGCGACTACAGCCTTCATGTGGCAGTGACGTGGTGGAGTGAC
CAGGTTAAAGAAGAAATGAAAATCCTTGTGCAAGATAAAGGTGTTAACTCTTTCAAGATG
TTTATGGCCTATAAAGATCTGTACATGGTGACAGACCTGGAGCTGTACGAAGCCTTCTCT
CGGTGCAAGGAAATTGGAGCAATTGCCCAGGTCCATGCGGAAAATGGAGACTTAATTGCA
GAGGGAGCAAAGAAGATGTTGGCTCTGGGGATAACAGGCCCTGAGGGCCACGAGCTGTGC
CGCCCAGAGGCAGTGGAGGCAGAGGCCACGCTGAGAGCCATCACCATAGCCAGCGCTGTG
AACTGTCCTCTCTACATTGTGCATGTGATGAGCAAGTCTGCAGCTAAGGTGATAGCGGAT
GCAAGGAGAGATGGGAAGGTGGTCTATGGTGAACCCATAGCAGCCAGTCTTGGCACAGAT
GGCACTCACTACTGGAATAAAGAATGGCACCATGCAGCCCACCATGTCATGGGTCCACCT
TTGCGACCAGACCCCTCAACACCCGACTTCCTCATGAATCTGTTGGCTAATGATGATCTA
ACCACAACAGGGACTGATAACTGCACTTTCAACACCTGCCAGAAAGCTCTTGGGAAGGAT
GATTTTACCAAGATCCCCAATGGGGTGAATGGTGTTGAAGATCGGATGTCCGTAATATGG
GAAAAAGGCGTGCATAGTGGTAAAATGGATGAAAACAGATTTGTGGCAGTTACCAGCACA
AATGCAGCCAAAATTTTTAATCTCTATCCAAGAAAAGGAAGAATAGCTGTAGGATCAGAT
GCTGACATTGTTATTTGGGACCCAAAAGGCACAAGGACTATCTCAGCAAAAACTCATCAT
CAGGCTGTTAACTTCAACATTTTCGAGGGCATGGTTTGCCACGGGGTGCCCCTTGTGACT
ATTTCAAGAGGCAAAGTGGTATATGAAGCCGGAGTGTTCAGTGTCACGGCAGGAGATGGG
AAGTTTATTCCTCGAAAACCATTTGCTGAATATATTTACAAACGAATAAAGCAGCGAGAC
CGGACTTGCACACCTACCCCTGTGGAGCGTGCACCCTATAAGGGAGAAGTCGCCACACTG
AAATCCAGAGTGACAAAAGAAGATGCCACAGCAGGGACCAGGAAACAGGCCCACCCCTGA


# Metabolic_Enzyme_2_GenBank_ID_Gene:
D78011

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_2_Locus:
8q22

# Metabolic_Enzyme_2_SNPs:
rs7825427; rs2298840; rs35013010; rs2853149; rs2853161; rs2246815; rs2333874; rs2669435; rs2246650; rs2669432; rs870789; rs2853150; rs2853178; rs2853169; rs2853164; rs2669429; rs1317472; rs2669436; rs1317380; rs1319371; rs2333871; rs2251371; rs2853168; rs1325; rs2853158; rs2853155; rs2853160; rs13263121; rs11783979; rs2853151; rs7821992; rs2853181; rs6468929; rs3737535; rs6468928; rs6999483; rs3793358; rs7000266; rs1513025; rs6989588; rs4734106; rs4305867; rs6468924; rs7004911; rs2669438; rs6989484; rs7012764; rs2853170; rs1513026; rs2246827; rs6994920; rs4734793; rs2853154; rs6468927; rs11989338; rs11779762; rs2853167; rs3133279; rs2250601; rs3793354; rs2853157; rs3793356; rs2853176; rs11995044; rs10505058; rs2853180; rs17245950; rs6989353; rs4734794; rs7014456; rs2853159; rs2853174; rs16871364; rs7012566; rs2669434; rs3793355; rs12675680; rs2669425; rs6468926; rs1962267; rs12679642; rs12545205; rs6994791; rs2669431; rs3793352; rs3793357; rs6983974; rs2669421; rs11987822; rs3133278; rs2853175; rs2253336; rs7010772; rs2853173; rs3793351; rs2853172; rs2669420; rs13271902; rs2669427; rs2669426; rs16871363; rs16871365; rs3793361; rs13249169; rs10808391; rs1327; rs4236774; rs2853156; rs2669430; rs2246821; rs16892397; rs13256669; rs1317357; rs13276697; rs2669437; rs6998185; rs13282328; rs10110355; rs2254738; rs13264598; rs2669419; rs16871466; rs3793353; rs4734797; rs7014134; rs10103147; rs2280010; rs7816369; rs17834440; rs6984745; rs2669423; rs13272770; rs3133281; rs2333875; rs12548603; rs3838708; rs2853179; rs4734798; rs17245780; rs2669424; rs2669433; rs7830021; rs4734796; rs2251374; rs1355691; rs16871361; rs16892398; rs6997991; rs2959024; rs2853148; rs2959025; rs36027551; rs34895123; rs35670436; rs35371065; rs2959023; rs6468925; rs6981049; rs11291771; rs34363633; rs36043601; rs35130488; rs35179334; rs5893687; rs34804847; rs34835869; rs34900729; rs3039791; rs3133280; rs34353212; rs1962266; rs34752863; rs35698680; rs13282051; rs17245479; rs34714020; rs34101301; rs34571719; rs33942215; rs35916478; rs34084483; rs35633624; rs7844185; rs35400656; rs11323937; rs35787438; rs2669439; rs2333870; rs28571799; rs35879325; rs35854847; rs10680569; rs28465605; rs4282534; rs35034310; rs35294948; rs35514435; rs10662772; rs5893685; rs11988300; rs1849444; rs35035392; rs35556854; rs34744515; rs2333873; rs36048718; rs2298841; rs35513452; rs35953220; rs2175692; rs35758944; rs13258070; rs10086232; rs5893688; rs7462383; rs13270458; rs34960309; rs34272796; rs34765621; rs11323938; rs2853152; rs35148727; rs35796122; rs35852759; rs35907176; rs1044403; rs35549842; rs2853162; rs34531171; rs2853171; rs7008591; rs34183780; rs2853130; rs34505030; rs13250630; rs35237634; rs3793360; rs6984037; rs11781253; rs7001837; rs28541850; rs11388669; rs35012619; rs34256594; rs4281090; rs35378953; rs3838709; rs28410924; rs35450967; rs7008920; rs34793099; rs1319386; rs2333872; rs2669428; rs2853163; rs13253383; rs34867904; rs11325699; rs35082298; rs5893686; rs35144447; rs34793262; rs3793359; rs36003516; rs36075709; rs3763515; rs34184625; rs28407196; rs34513404; rs10101743; rs1105622; rs11779233; rs11782457; rs11997948; rs12541941; rs12543989; rs1316456; rs1317221; rs1355692; rs2669440; rs2853135; rs2853136; rs2853138; rs2853139; rs2853140; rs2853141; rs2853142; rs2853143; rs2853144; rs2853145; rs2942570; rs2959026; rs2959027; rs35349928; rs3750187; rs4734787; rs4734788; rs4734790; rs6992445

# Metabolic_Enzyme_2_General_References:
8973361; 9718352

# Metabolic_Enzyme_2_References:
Not Available

End of HMDB00079

Beginning of HMDB00082
# Accession_No:
HMDB00082

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-05-23 11:41:47

# biospider_lastupdate:
2007-07-24 14:07:28

# Common_Name:
Cytidine triphosphate

# Description:
Cytidine 5'-(tetrahydrogen triphosphate) or CTP is a cytosine nucleotide containing three phosphate groups esterified to a ribose moiety at the 5' position. CTP is integral to the synthesis or mRNA, rRNA and tRNA through RNA polymerases.  Cytidine triphosphate (CTP) is also critical to the synthesis of phosphatidylcholine via the enzyme CTP: phosphocholine cytidyltransferase. This reaction is the rate-limiting step in the synthesis of phosphatidylcholine.

# Synonyms:
cytidine 5'-(tetrahydrogen triphosphate); Deoxycytosine triphosphate; Cytidine mono(tetrahydrogen triphosphate) (ester); cytidine-5'-triphosphate; H4ctp; Cytidine 5'-triphosphate; 5'-(tetrahydrogen triphosphate) cytidine; Cytidine 5-Prime-Triphosphate; CTP; Cytidine 5'-triphosphoric acid; Cytidine 3'-triphosphate; 5'-CTP; Cytidine Triphosphate; Cytidine mono; Cytidine triphosphic acid

# Chemical_IUPAC_Name:
[[[5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid

# Chemical_Formula:
C9H16N3O14P3

# Chemical_Structure:
tbl_chemical:::HMDB00082_ZOOM.png:::119283179915911665

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00082_THUMB.png:::11928317970775078

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines; Nucleoside Triphosphates

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; secondary alcohol; 1,2-diol; primary amine; primary aromatic amine; oxo(het)arene; urea; phosphoric acid ester; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of Aminophosphonate metabolism; Component of Aminosugars metabolism; Component of Glycerophospholipid metabolism; Component of Pyrimidine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
482.98450

# Molecular_Weight_Avg:
483.15631

# Smiles_String_isomeric:
NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O

# Smiles_String_canonical:
NC1=NC(=O)N(C=C1)C2OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C2O

# KEGG_Compound_ID:
C00063

# BioCyc_ID:
CTP

# PubChem_CID:
6176

# PubChem_SID:
14716334; 831580; 585636; 835987; 836565; 7838932; 854629; 149079; 820930; 17403751; 833278; 3363; 831581; 831550; 831582; 17422291; 831577; 6436289; 14716338; 17422221; 831579; 8026480; 14859169; 24277455; 831576; 584557; 17436064; 831578; 24277450; 583994; 24277445; 822408; 24775908; 6436288; 17436068; 14716332; 7886800; 7979002; 841749; 821539; 8144860; 831574; 836267; 826642; 833258; 831575; 584298

# OMIM_ID:
123860; 300380

# Metagene_ID:
Not Available

# BiGG_ID:
33710

# Wikipedia_ID:
Cytidine triphosphate

# METLIN_ID:
5136

# Ref_ID:
15735103; 2888306; 2547243; 4025817; 11532523; 10973058

# ChEBI_ID:
17677

# CAS_Registry_Number:
65-47-4

# InChI:
InChI=1/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

# Synthesis_Reference:
 Journal of the American Chemical Society  (1988),  110(21),  7159-63.

# Melting_Point:
215-218 oC

# Melting_Point_predicted:
154.8 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
11.2 mg/mL [Predicted by ALOGPS]

# phys_charge:
-4

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-0.34 [Predicted by ALOGPS]; -6.7 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00063.mol:::1132723805781462995

# SDF_File_[Text]:
tbl_chemical:::HMDB00082.sdf:::11928317916259725

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00082.pdb:::119283179569768576

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::060308_P00_10_1DP_Presat.png:::116136802302696218

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::060308_P00_10_1DP_Presat.zip:::116136499962794988

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::060308_P00_10_1DP_Assigned.png:::117511835638544755

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::060308_P00_10_2DHSQC_1134.png:::116422705158724922

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::060308_P00_10_2DHSQC_1134.zip:::116422705159434707

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::Cytidine triphosphate (HMDB00082).png:::117346692452088080

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Cytidine 5'-triphosphate.gif:::1132732106515869811

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00082_peaks.txt:::1156309533795929943

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Cytidine 5'-triphosphate_C.gif:::1132737678137251568

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00082_peaks.txt:::1156310724134778297

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00082L.png:::117555265767448297; Medium Energy:tbl_ms:::HMDB00082M.png:::117555270135026068; High Energy:tbl_ms:::HMDB00082H.png:::117555272345990936

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000277.png:::116907445523449865

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000277.txt:::116907445523438117

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000277.png:::116890834090651856

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000277.txt:::116890834118735918

# Cellular_Location:
Nucleus; Cytoplasm; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; Cellular Cytoplasm

# Concentration_[Normal]:
Cellular_Cytoplasm	0	uM	Adult:>18_yrs_old	Both	Normal	2888306
Cellular_Cytoplasm	10	uM	Adult:>18_yrs_old	Both	Normal	4025817
Cellular_Cytoplasm	28	uM	Adult:>18_yrs_old	Both	Normal	4025817
Cellular_Cytoplasm	15	uM	Adult:>18_yrs_old	Both	Normal	4025817
Cellular_Cytoplasm	23	uM	Adult:>18_yrs_old	Both	Normal	4025817


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Pyrimidine 5'-nucleotidase (P5N) deficiency

# Pathway_Names:
Glycerophospholipid metabolism;Purine metabolism;Glycolysis;Fructose and mannose metabolism;Galactose metabolism;Aminosugars metabolism;Phosphatidylinositol signaling system;Pyruvate metabolism

# Pathway_Images:
;Purine_Synthesis.jpg;Glycolysis.jpg;fructose_metabolism.jpg;;;;

# KEGG_Images:
map00564;map00230;map00010;map00051;map00052;map00530;map04070;map00620

# Pathway_Graphs:
;Purine_Synthesis_Graph.jpg;Glycolysis_Graph.jpg;fructose_metabolism_Graph.jpg;;;;

# Pathway_SBMLs:
;Purine_Synthesis.xml;Glycolysis.xml;fructose_metabolism.xml;;;;

# Metabolic_Enzyme_1_ID:
6007

# Metabolic_Enzyme_1_Name:
Choline-phosphate cytidylyltransferase B

# Metabolic_Enzyme_1_Synonyms:
Phosphorylcholine transferase B; CTP:phosphocholine cytidylyltransferase B; CT B; CCT B; CCT-beta

# Metabolic_Enzyme_1_Gene_Name:
PCYT1B

# Metabolic_Enzyme_1_Protein_Sequence:
>Cholinephosphate cytidylyltransferase 
BMPVVTTDAESETGIPKSLSNEPPSETMEEIEHTCPQPRLTLTAPAPFADETNCQCQAPH
EKLTIAQARLGTPADRPVRVYADGIFDLFHSGHARALMQAKTLFPNSYLLVGVCSDDLTH
KFKGFTVMNEAERYEALRHCRYVDEVIRDAPWTLTPEFLEKHKIDFVAHDDIPYSSAGSD
DVYKHIKEAGMFVPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKR
YRFQNQVDKMKEKVKNVEERSKEFVNRVEEKSHDLIQKWEEKSREFIGNFLELFGPDGAW
KQMFQERSSRMLQALSPKQSPVSSPTRSRSPSRSPSPTFSWLPLKTSPPSSPKAASASIS
SMSEGDEDEK

# Metabolic_Enzyme_1_Number_of_Residues:
369

# Metabolic_Enzyme_1_Molecular_Weight:
41940

# Metabolic_Enzyme_1_Theoretical_pI:
6.36

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_1_Specific_Function:
Controls phosphatidylcholine synthesis

# Metabolic_Enzyme_1_Pathway:
map00440  Aminophosphonate metabolism;
 map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_1_Reaction:
CTP + choline phosphate = diphosphate + CDP-choline

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01467:CTP_transf_2

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.7.7.15

# Metabolic_Enzyme_1_GenBank_ID_Protein:
3153239

# Metabolic_Enzyme_1_SwissProt_ID:
PCY1B_HUMAN (Q9Y5K3)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
PCYT1B

# Metabolic_Enzyme_1_Geneatlas_id:
PCYT1B

# Metabolic_Enzyme_1_hgnc_id:
HGNC:8755

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Endoplasmic reticulum

# Metabolic_Enzyme_1_Gene_Sequence:
>993 bp
ATGCCAGTAGTTACCACTGATGCTGAGTCAGAAACAGGTATCCCAAAATCCCTTTCCAAT
GAGCCTCCCTCAGAAACCATGGAGGAAATAGAGCACACATGCCCACAGCCTCGACTGACC
CTGACTGCACCTGCCCCATTTGCTGATGAAACCAACTGCCAGTGTCAAGCACCCCATGAA
AAACTGACCATTGCTCAGGCCCGCTTAGGAACACCAGCTGACAGGCCTGTCAGAGTATAC
GCCGATGGAATATTTGACCTCTTCCACTCAGGTCATGCAAGAGCCCTTATGCAAGCAAAA
ACACTGTTTCCCAACAGCTACTTGTTGGTAGGAGTTTGCAGTGATGATCTCACCCACAAA
TTCAAAGGTTTCACCGTGATGAATGAAGCCGAGAGATACGAAGCTCTCAGACACTGTCGC
TACGTAGACGAAGTTATCAGAGATGCTCCCTGGACACTCACGCCAGAGTTTCTGGAAAAA
CACAAGATTGACTTTGTGGCTCATGATGACATTCCGTATTCCTCTGCTGGCTCTGATGAT
GTTTACAAGCACATAAAGGAAGCAGGGATGTTCGTTCCAACGCAGAGAACAGAAGGCATC
TCAACATCGGACATCATTACCAGAATTGTTCGTGACTATGATGTTTATGCCCGACGTAAC
CTCCAGAGAGGGTATACAGCCAAGGAACTGAATGTCAGCTTTATAAATGAGAAGAGGTAC
CGTTTCCAGAACCAAGTGGACAAAATGAAGGAAAAAGTCAAGAATGTGGAGGAAAGATCA
AAGGAATTTGTGAACAGAGTGGAAGAAAAGAGCCATGATCTAATTCAAAAGTGGGAAGAG
AAGTCAAGGGAATTCATTGGCAACTTCCTAGAACTGTTTGGACCTGATGGAGCATGGAAG
CAGATGTTCCAGGAGAGGAGCAGCCGGATGCTGCAGGCCTTATCCCCGAAGCAGAGCCCT
CTGAAGAGTTGGGCGAGGTGCAGAGACTTCTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF052510

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_1_Locus:
Xp22.11

# Metabolic_Enzyme_1_SNPs:
rs7060616; rs1207651; rs10156959; rs3761610; rs2178608; rs3761612; rs12689316; rs3761611; rs7060633; rs5986619; rs2319654; rs1921918; rs1921919; rs2214600; rs984059; rs1921917; rs1921920; rs6629900; rs6653705; rs2874037; rs4898282; rs3788916; rs4898188; rs6653706; rs12011918; rs1882402; rs5944622; rs5944612; rs1882403; rs1921921; rs718676; rs2091746; rs5944661; rs1921923; rs5944640; rs5986349; rs2222865; rs6418542; rs1343641; rs5944549; rs1211414; rs3747401; rs12687181; rs1635265; rs12851930; rs6526400; rs2319591; rs1921924; rs12688556; rs1921922; rs5986698; rs16983194; rs12009599; rs5944656; rs5986338; rs5944657; rs6526393; rs6526401; rs12116104; rs5943964; rs4243532; rs5944655; rs5944660; rs12689847; rs6653704; rs4898192; rs6526399; rs7878069; rs16983189; rs12009804; rs17265665; rs4898279; rs16983188; rs6526391; rs7066434; rs6628023; rs4898285; rs5986669; rs12011722; rs7053470; rs16983175; rs1624893; rs5986350; rs7878802; rs5944658; rs3788915; rs4297206; rs1209705; rs5986351; rs5986352; rs5944659; rs5986339; rs6629897; rs12846498; rs6629883; rs12687329; rs6526395; rs4898280; rs5986697; rs5944531; rs7879096; rs12833849; rs4898190; rs5986672; rs11796289; rs1207650; rs5944553; rs4436288; rs5986633; rs1921925; rs5944648; rs1882404; rs1921926; rs1882405; rs17217752; rs1133910; rs6628025; rs34701484; rs41303157; rs12845774; rs3196061; rs41303163; rs41303159; rs3196062; rs5901756; rs41303161; rs34052072; rs41309687; rs35577874; rs5901755; rs7060747; rs12389731; rs12009280; rs12687130; rs6629893; rs35688898; rs34644362; rs12009277; rs6653708; rs34286045; rs5943944; rs12841082; rs34826542; rs5944542; rs12009202; rs34466811; rs10545140; rs3833417; rs7053311; rs12852115; rs5943980; rs35422981; rs11798800; rs12844713; rs7054128; rs6629894; rs35531228; rs35951444; rs5986330; rs34944920; rs16997718; rs7877779; rs5943943; rs7878935; rs35733987; rs5944541; rs9698609; rs7878801; rs12558111; rs10548369; rs41305197; rs5901758; rs5944652; rs12848987; rs6629885; rs11325321; rs12383145; rs6628026; rs35246139; rs7877800; rs12845511; rs7059020; rs12558112; rs12845513; rs1635264; rs6653707; rs7877785; rs7878821; rs6629892; rs2178607; rs5944653; rs35285894; rs12848148; rs34733241; rs6629899; rs34539497; rs12847153; rs10655151; rs12842722; rs12846272; rs7889358; rs34014326; rs34441956; rs12560185; rs7879328; rs35221784; rs6628020; rs35470382; rs34942756; rs34014544; rs6628027; rs12846410; rs35763560; rs5901757; rs35361795; rs12009923; rs35085832; rs11354588; rs5944654; rs1212947; rs34181498; rs6653703; rs34422780; rs34510307; rs5986699; rs7053649; rs28516956; rs34791589; rs2906000; rs35584421; rs6629884; rs5944540; rs6628021; rs6629882; rs35284868; rs35072094; rs5943914; rs2704815; rs3214208; rs35764351; rs6629902; rs41311489; rs6629901; rs1055186; rs1207612; rs1207613; rs1207615; rs1207653; rs1212946; rs12836759; rs16983125; rs2250315; rs2464543; rs4141263; rs4898273; rs5944667; rs5986614; rs6629878; rs7050799; rs7051231; rs7876880

# Metabolic_Enzyme_1_General_References:
9593753; 10480912

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6008

# Metabolic_Enzyme_2_Name:
DNA-directed RNA polymerase II 19 kDa polypeptide

# Metabolic_Enzyme_2_Synonyms:
RPB7

# Metabolic_Enzyme_2_Gene_Name:
POLR2G

# Metabolic_Enzyme_2_Protein_Sequence:
>DNAdirected RNA polymerase II 19 kDa polypeptide
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

# Metabolic_Enzyme_2_Number_of_Residues:
172

# Metabolic_Enzyme_2_Molecular_Weight:
19295

# Metabolic_Enzyme_2_Theoretical_pI:
5.23

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  RNA binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Transcription 

# Metabolic_Enzyme_2_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It is suggested that POLR2G contributes to the function of RNA polymerase II in the absence of POLR2D either in a manner independent of its association with the enzyme or by directly binding to the enzyme in a manner independent of its association with POLR2D

# Metabolic_Enzyme_2_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_2_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF03876:RNA_pol_Rpb7_N;
PF00575:S1

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_2_GenBank_ID_Protein:
929921

# Metabolic_Enzyme_2_SwissProt_ID:
RPB7_HUMAN (P62487)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
POLR2G

# Metabolic_Enzyme_2_Geneatlas_id:
POLR2G

# Metabolic_Enzyme_2_hgnc_id:
HGNC:9194

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_2_Gene_Sequence:
>519 bp
ATGTTCTACCATATCTCCCTAGAGCACGAAATCCTGCTGCACCCGCGCTACTTCGGCCCC
AACTTGCTCAACACGGTGAAGCAGAAGCTCTTCACCGAGGTGGAGGGGACCTGCACAGGG
AAGTATGGCTTTGTAATTGCTGTCACCACCATTGACAATATTGGTGCTGGTGTGATCCAG
CCAGGCCGAGGCTTTGTCCTTTATCCAGTTAAGTACAAGGCCATTGTTTTCCGGCCATTT
AAAGGGGAGGTCGTGGATGCTGTTGTCACTCAGGTCAACAAGGTTGGACTCTTCACAGAA
ATTGGGCCCATGTCTTGCTTCATCTCTCGACATTCCATCCCTTCAGAGATGGAGTTTGAT
CCTAACTCCAACCCACCATGTTACAAGACAATGGATGAGGATATTGTGATTCAGCAGGAC
GATGAGATCCGCTTAAAGATTGTGGGGACCCGTGTGGACAAGAATGACATTTTTGCTATT
GGCTCCCTGATGGACGATTACTTGGGGCTTGTAAGCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
U20659

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_2_Locus:
11q13.1

# Metabolic_Enzyme_2_SNPs:
rs2509680; rs2467647; rs4061933; rs486723; rs4963318; rs7121488; rs34019469; rs11548441; rs1045097; rs3795; rs1045122; rs1045125; rs1045183; rs1802756; rs41553312; rs41553130; rs2439912; rs41542313; rs34286520; rs35157186; rs35111699; rs640681; rs2957001; rs12289608; rs1128271; rs3016807; rs2957000; rs1300144; rs2510538; rs11231206; rs35707057; rs557939; rs35168807; rs2467648; rs2957123; rs35730843; rs2510537; rs12789291; rs34237396; rs34820872; rs10581323; rs11231207; rs11231210; rs11603028; rs11603549; rs2510082; rs2584917; rs2730031; rs2873105; rs3017668; rs3829248; rs491333; rs506132; rs530299; rs534117; rs544641; rs567791; rs572513; rs679626; rs693738

# Metabolic_Enzyme_2_General_References:
7579693; 9256063

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6009

# Metabolic_Enzyme_3_Name:
6-phosphofructokinase type C

# Metabolic_Enzyme_3_Synonyms:
Phosphofructokinase 1; Phosphohexokinase; Phosphofructo-1-kinase isozyme C; PFK-C; 6- phosphofructokinase, platelet type

# Metabolic_Enzyme_3_Gene_Name:
PFKP

# Metabolic_Enzyme_3_Protein_Sequence:
>6phosphofructokinase type 
CMDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYF
IYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGI
TNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFC
GTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFL
PESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYD
TRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLME
CVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVG
APAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGT
KRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATV
SNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAG
ADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGK
GVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICV
LGISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHV
QPWSV

# Metabolic_Enzyme_3_Number_of_Residues:
784

# Metabolic_Enzyme_3_Molecular_Weight:
85597

# Metabolic_Enzyme_3_Theoretical_pI:
7.60

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  phosphofructokinase activity
Function:  6-phosphofructokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  protein complex
Component:  6-phosphofructokinase complex
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_3_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

# Metabolic_Enzyme_3_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00030  Pentose phosphate pathway;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism

# Metabolic_Enzyme_3_Reaction:
ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00365:PFK

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.7.1.11

# Metabolic_Enzyme_3_GenBank_ID_Protein:
560105

# Metabolic_Enzyme_3_SwissProt_ID:
K6PP_HUMAN (Q01813)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
PFKP

# Metabolic_Enzyme_3_Geneatlas_id:
PFKP

# Metabolic_Enzyme_3_hgnc_id:
HGNC:8878

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>2355 bp
ATGGACGCGGACGACTCCCGGGCCCCCAAGGGCTCCTTGCGGAAGTTCCTGGAGCACCTC
TCCGGGGCCGGCAAGGCCATCGGCGTGCTGACCAGCGGCGGGGATGCTCAAGGTATGAAC
GCTGCCGTCCGTGCCGTGGTGCGCATGGGTATCTACGTGGGGGCCAAGGTGTACTTCATC
TACGAGGGCTACCAGGGCATGGTGGACGGAGGCTCAAACATCGCAGAGGCCGACTGGGAG
AGTGTCTCCAGCATCCTGCAAGTGGGCGGGACGATCATTGGCAGTGCGCGGTGCCAGGCC
TTCCGCACGCGGGAAGGCCGCCTGAAGGCTGCTTGCAACCTGCTGCAGCGCGGCATCACC
AACCTGTGTGTGATCGGCGGGGACGGGAGCCTCACCGGGGCCAACCTCTTCCGGAAGGAG
TGGAGTGGGCTGCTGGAGGAGCTGGCCAGGAACGGCCAGATCGATAAGGAGGCCGTGCAG
AAGTACGCCTACCTCAACGTGGTGGGCATGGTGGGCTCCATCGACAATGATTTCTGCGGC
ACCGACATGACCATCGGCACGGACTCCGCCCTGCACAGGATCATCGAGGTCGTCGACGCC
ATCATGACCACGGCCCAGAGCCACCAGAGGACCTTCGTTCTGGAGGTGATGGGACGACAC
TGTGGGTACCTGGCCCTGGTGAGTGCCTTGGCCTGCGGTGCGGACTGGGTGTTCCTTCCA
GAATCTCCACCAGAGGAAGGCTGGGAGGAGCAGATGTGTGTCAAACTCTCGGAGAACCGT
GCCCGGAAAAAAAGGCTGAATATTATTATTGTGGCTGAAGGAGCAATTGATACCCAAAAT
AAACCCATCACCTCTGAGAAAATCAAAGAGCTTGTCGTCACGCAGCTGGGCTATGACACA
CGTGTGACCATCCTCGGGCACGTGCAGAGAGGAGGGACCCCTTCGGCATTCGACAGGATC
TTGGCCAGCCGCATGGGAGTGGAGGCAGTCATCGCCTTGCTAGAGGCCACCCCGGACACC
CCAGCTTGCGTCGTGTCACTGAACGGGAACCACGCCGTGCGCCTGCCGCTGATGGAGTGC
GTGCAGATGACTCAGGATGTGCAGAAGGCGATGGACGAGAGGAGATTTCAAGATGCGGTT
CGACTCCGAGGGAGGAGCTTTGCGGGCAACCTGAACACCTACAAGCGACTTGCCATCAAG
CTGCCGGATGATCAGATCCCAAAGACCAATTGCAACGTAGCTGTCATCAACGTGGGGGCA
CCCGCGGCTGGGATGAACGCGGCCGTACGCTCAGCTGTGCGCGTGGGCATTGCCGACGGC
CACAGGATGCTCGCCATCTATGATGGCTTTGACGGCTTCGCCAAGGGCCAGATCAAAGAA
ATCGGCTGGACAGATGTCGGGGGCTGGACCGGCCAAGGAGGCTCCATTCTTGGGACAAAA
CGCGTTCTCCCGGGGAAGTACTTGGAAGAGATCGCCACACAGATGCGCACGCACAGCATC
AACGCGCTGCTGATCATCGGTGGATTCGAGGCCTACCTGGGACTCCTGGAGCTGTCAGCC
GCCCGGGAGAAGCACGAGGAGTTCTGTGTCCCCATGGTCATGGTTCCCGCTACTGTGTCC
AACAATGTGCCGGGTTCCGATTTCAGCATCGGGGCAGACACCGCCCTGAACACTATCACC
GACACCTGCGACCGCATCAAGCAGTCCGCCAGCGGAACCAAGCGGCGCGTGTTCATCATC
GAGACCATGGGCGGCTACTGTGGCTACCTGGCCAACATGGGGGGGCTCGCGGCCGGAGCT
GATGCCGCATACATTTTCGAAGAGCCCTTCGACATCAGGGATCTGCAGTCCAACGTGGAG
CACCTGACGGAGAAAATGAAGACCACCATCCAGAGAGGCCTTGTGCTCAGAAATGAGAGC
TGCAGTGAAAACTACACCACCGACTTCATTTACCAGCTGTATTCAGAAGAGGGCAAAGGC
GTGTTTGACTGCAGGAAGAACGTGCTGGGTCACATGCAGCAGGGTGGGGCACCCTCTCCA
TTTGATAGAAACTTTGGAACCAAAATCTCTGCCAGAGCTATGGAGTGGATCACTGCAAAA
CTCAAGGAGGCCCGGGGCAGAGGAAAAAAATTTACCACCGATGATTCCATTTGTGTGCTG
GGAATAAGCAAAAGAAACGTTATTTTTCAACCTGTGGCAGAGCTGAAGAAGCAAACGGAT
TTTGAGCACAGGATTCCCAAAGAACAGTGGTGGCTCAAGCTACGGCCCCTCATGAAAATC
CTGGCCAAGTACAAGGCCAGCTATGACGTGTCGGACTCAGGCCAGCTGGAACATGTGCAG
CCCTGGAGTGTCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
D25328

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_3_Locus:
10p15.3-p15.2

# Metabolic_Enzyme_3_SNPs:
rs2306302; rs1132173; rs4881086; rs12572717; rs1052333; rs1052309; rs11251721; rs11542779; rs11542777; rs11542780; rs1052337; rs35828349; rs4881080; rs3816699; rs9063; rs1052929; rs1053000; rs542; rs543; rs541; rs7673; rs3816712; rs2388564; rs867274; rs2388595; rs2306294; rs2306297; rs7901550; rs2306310; rs7913237; rs2279211; rs10508245; rs2388510; rs6602029; rs2892550; rs3814587; rs4881099; rs7080240; rs6602028; rs2306312; rs3829915; rs2306304; rs7896691; rs7086721; rs7923989; rs7916889; rs6602030; rs2279215; rs6602027; rs4881091; rs2306311; rs2279212; rs7922072; rs4391741; rs2388594; rs10795000; rs4611105; rs3814590; rs730141; rs9423693; rs7100185; rs4881101; rs4390256; rs2306305; rs4881084; rs2279208; rs882849; rs7913473; rs7902549; rs7096334; rs4545444; rs7082863; rs2306299; rs7924111; rs4381274; rs4880592; rs10903969; rs9630129; rs7075489; rs7096442; rs12268267; rs11819604; rs11251702; rs7076989; rs2306293; rs12569790; rs11817505; rs12570754; rs7082524; rs17284739; rs9423690; rs2388565; rs4881105; rs4881098; rs10508246; rs7918368; rs11251694; rs10903970; rs4881074; rs10903959; rs4881085; rs4517415; rs2388566; rs7342021; rs2306309; rs7894036; rs10794999; rs4881075; rs12569846; rs7091322; rs10903967; rs9423462; rs10903972; rs11251727; rs2388569; rs7901589; rs11591441; rs3829914; rs4598574; rs3816698; rs4881093; rs9423474; rs11251724; rs3740613; rs2306307; rs2306314; rs9423467; rs7896260; rs10903974; rs2892554; rs4595438; rs4881079; rs2388567; rs17131897; rs3816701; rs9423466; rs11592061; rs11251697; rs7086902; rs11251741; rs2306316; rs3814588; rs12257705; rs10903962; rs7080058; rs11599851; rs7910054; rs17212803; rs872398; rs17132175; rs2306306; rs9423487; rs2306315; rs6602032; rs10903955; rs10903961; rs3814589; rs4306207; rs11818475; rs4881077; rs9423680; rs4881087; rs9423489; rs2279210; rs7075876; rs9423490; rs6602031; rs11251723; rs12762657; rs11812979; rs11251711; rs10903954; rs12776036; rs4881097; rs7083162; rs2279206; rs4269839; rs7094776; rs7903250; rs9423491; rs10751913; rs12253549; rs7915793; rs7906901; rs2388570; rs3842695; rs9804219; rs3829917; rs11251719; rs12572060; rs4881082; rs4256893; rs9423471; rs10903960; rs17132578; rs2279207; rs7091146; rs7896897; rs7071398; rs12415723; rs9423464; rs7918168; rs11251729; rs4880590; rs7902539; rs4999370; rs9804221; rs2388552; rs7907949; rs9423681; rs11251732; rs11251707; rs4881081; rs7900748; rs10795002; rs11815740; rs17285851; rs4881078; rs3829916; rs7896829; rs7074733; rs11251709; rs9423685; rs12247270; rs11598339; rs10903968; rs7898894; rs3740611; rs7900171; rs17135865; rs2279204; rs4271292; rs12412712; rs9423469; rs10430751; rs9423472; rs11251696; rs7915264; rs12769974; rs9423692; rs11592619; rs4881095; rs7913254; rs7094648; rs11251742; rs11251695; rs9423691; rs2306301; rs2279209; rs7090199; rs9423698; rs7909171; rs3816703; rs4469783; rs10751914; rs10903966; rs3740610; rs11818602; rs9423473; rs2279205; rs1107048; rs11251734; rs11251728; rs2388571; rs9423485; rs7076698; rs11251710; rs11591990; rs6602023; rs9423494; rs4391742; rs8181285; rs2388573; rs4424569; rs10795004; rs9423695; rs3829912; rs11595224; rs11251715; rs7088110; rs10903957; rs10903973; rs7916196; rs7893663; rs10795005; rs11251720; rs4881094; rs9423476; rs4881089; rs10903963; rs3829911; rs2388574; rs4881100; rs9423475; rs9423686; rs2279213; rs10903958; rs6602026; rs3842696; rs7901291; rs9423477; rs3740612; rs7896500; rs2279203; rs10751912; rs2388568; rs4281389; rs6602022; rs7079667; rs872399; rs11251730; rs9804296; rs9423697; rs4881090; rs9423492; rs2388551; rs11251693; rs11595461; rs3814591; rs4881088; rs11595530; rs9423689; rs12357621; rs11591423; rs12414599; rs7914782; rs12245370; rs12258216; rs7074889; rs10458792; rs10430770; rs2388592; rs12358995; rs3816700; rs10903953; rs10795003; rs7100037; rs11251733; rs12772110; rs4881083; rs6602024; rs4881092; rs9423470; rs9423479; rs3830218; rs10508244; rs2388550; rs7902685; rs7342119; rs4589191; rs2306308; rs2388563; rs4881106; rs12772817; rs7079217; rs2388562; rs41288721; rs11542782; rs11542778; rs34180069; rs17852638; rs41288715; rs11542781; rs3816704; rs3841604; rs11251743; rs34020709; rs9423465; rs11419779; rs12249060; rs9423481; rs11251716; rs12246252; rs35454947; rs10552241; rs10528387; rs12571307; rs2306318; rs7903389; rs4991347; rs35621470; rs2306303; rs34612453; rs11251703; rs36062383; rs41288731; rs41285619; rs41288717; rs35044971; rs36124101; rs34773391; rs7914040; rs10611976; rs36123078; rs10458791; rs35763309; rs7342088; rs35304719; rs7893811; rs34970131; rs10673964; rs9423483; rs7087044; rs11312438; rs9423682; rs35870724; rs41288727; rs7911657; rs9423480; rs11251712; rs35129023; rs11473992; rs35998692; rs34554786; rs7078002; rs10606109; rs10458790; rs12243817; rs35551233; rs10578594; rs41288713; rs4991348; rs34810963; rs6143743; rs2388572; rs10552310; rs11251726; rs9423482; rs7083310; rs11599643; rs11593072; rs33926028; rs9423463; rs6602025; rs12571292; rs4002022; rs35375917; rs34822234; rs34387880; rs41288719; rs11418900; rs34547664; rs34978134; rs5782687; rs10736966; rs5782680; rs10795006; rs10795001; rs7921605; rs11251717; rs34543032; rs11251705; rs4575170; rs2306317; rs4881096; rs11364694; rs41288729; rs9423684; rs35591312; rs5782685; rs3841457; rs11251708; rs34980049; rs34937212; rs10606110; rs7911305; rs3892593; rs7917172; rs34361470; rs7903088; rs4881076; rs11251704; rs9423461; rs35755098; rs34626444; rs35455312; rs7342001; rs2388591; rs36089632; rs9630123; rs5782686; rs4584487; rs10903964; rs9423688; rs41288711; rs34625271; rs34795068; rs35308134; rs34196028; rs33989675; rs12267216; rs11251698; rs35246156; rs3830217; rs11426937; rs10903965; rs5782683; rs35671672; rs10082547; rs9423484; rs12411383; rs2306300; rs11251740; rs9423460; rs35879516; rs2306296; rs9423687; rs34920157; rs11251737; rs7072300; rs34441916; rs7905464; rs12775265; rs11251736; rs34485324; rs12249143; rs35163491; rs3829913; rs35686601; rs11251731; rs9423694; rs35648106; rs3042667; rs11394580; rs28673062; rs12767011; rs12355909; rs7912275; rs11251725; rs5782684; rs12762623; rs34538474; rs7921718; rs28433695; rs35568047; rs12777199; rs35863365; rs12772744; rs34260521; rs6143744; rs12769056; rs2388575; rs12773602; rs7913100; rs11251739; rs2892549; rs35072017; rs11251701; rs11251714; rs4880589; rs34688896; rs35741420; rs11251706; rs35276282; rs11375841; rs11251722; rs2306298; rs12411396; rs12769988; rs35751635; rs34430271; rs12250915; rs35571366; rs35303123; rs41288723; rs2388576; rs7071824; rs4880591; rs34453449; rs41288733; rs5782681; rs9423478; rs11251699; rs7072286; rs6143745; rs34390372; rs9702390; rs12355948; rs34128386; rs34273901; rs7896922; rs7919798; rs7474978; rs35768855; rs12412657; rs11251700; rs11251738; rs7898754; rs7082466; rs7071339; rs10582528; rs34600605; rs7088709; rs35381145; rs7093888; rs5782682; rs11251718; rs10903956; rs2306313; rs12571066; rs35890906; rs9423486; rs6143747; rs6143746; rs10175; rs1043146; rs1043158; rs1043166; rs10508247; rs10736965; rs10751909; rs10794997; rs10794998; rs10795007; rs11251688; rs11251744; rs12678; rs12762013; rs12774814; rs12779561; rs12780595; rs17135477; rs17136264; rs17212411; rs17849904; rs1802344; rs1804254; rs2279216; rs2279217; rs2279218; rs2279219; rs2279220; rs2279221; rs2306319; rs2388558; rs2388559; rs2388560; rs2388561; rs34837384; rs34882494; rs35301243; rs35363509; rs35779348; rs3752802; rs3752803; rs3758630; rs3758631; rs3814586; rs4451611; rs4880594; rs4880595; rs4881107; rs4881109; rs4881110; rs6901; rs7081092; rs7094698; rs7097793; rs7898290; rs7898695; rs7904857; rs7908746; rs7911918; rs7924163; rs9129; rs9423495; rs9423701; rs9423702; rs9423703

# Metabolic_Enzyme_3_General_References:
8117307; 1834056

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5338

# Metabolic_Enzyme_4_Name:
Nucleoside diphosphate kinase, mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
NDP kinase, mitochondrial; NDK; nm23-H4; Nucleoside diphosphate kinase D; NDPKD

# Metabolic_Enzyme_4_Gene_Name:
NME4

# Metabolic_Enzyme_4_Protein_Sequence:
>Nucleoside diphosphate kinase, mitochondrial precursor
MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGPSWTRERTLVAVKPDGVQRRLVGDVIQR
FERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRAS
RAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQ
HSSIHPA

# Metabolic_Enzyme_4_Number_of_Residues:
187

# Metabolic_Enzyme_4_Molecular_Weight:
20659

# Metabolic_Enzyme_4_Theoretical_pI:
10.75

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  nucleoside diphosphate kinase activity
 ||
>>>
Process:  CTP biosynthesis
Process:  nucleoside triphosphate metabolism
Process:  nucleoside triphosphate biosynthesis
Process:  ribonucleoside triphosphate biosynthesis
Process:  pyrimidine ribonucleoside triphosphate biosynthesis
Process:  UTP biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside triphosphate biosynthesis
Process:  purine ribonucleoside triphosphate biosynthesis
Process:  GTP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Major role in the synthesis of nucleoside triphosphates other than ATP

# Metabolic_Enzyme_4_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_4_Reaction:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00334:NDK

# Metabolic_Enzyme_4_Signals:
1-15

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.7.4.6

# Metabolic_Enzyme_4_GenBank_ID_Protein:
1945762

# Metabolic_Enzyme_4_SwissProt_ID:
NDKM_HUMAN (O00746)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
NME4

# Metabolic_Enzyme_4_Geneatlas_id:
NME4

# Metabolic_Enzyme_4_hgnc_id:
HGNC:7852

# Metabolic_Enzyme_4_PDB_ID:
1EHW

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion; mitochondrial intermembrane space

# Metabolic_Enzyme_4_Gene_Sequence:
>564 bp
ATGGGCGGCCTCTTCTGGCGCTCCGCGCTGCGGGGGCTGCGCTGCGGCCCGCGGGCCCCG
GGCCCGAGCCTGCTAGTGCGCCACGGCTCGGGAGGGCCCTCCTGGACCCGGGAGCGGACC
CTGGTGGCGGTGAAGCCCGATGGCGTGCAACGGCGGCTCGTTGGGGACGTGATCCAGCGC
TTTGAGAGGCGGGGCTTCACGCTGGTGGGGATGAAGATGCTGCAGGCACCAGAGAGCGTC
CTTGCCGAGCACTACCAGGACCTGCGGAGGAAGCCCTTCTACCCTGCCCTCATCCGCTAC
ATGAGCTCTGGGCCTGTGGTGGCCATGGTCTGGGAAGGGTACAATGTCGTCCGCGCCTCA
AGGGCCATGATTGGACACACCGACTCGGCTGAGGCTGCCCCAGGAACCATAAGGGGTGAC
TTCAGCGTCCACATCAGCAGGAATGTCATCCACGCCAGCGACTCCGTGGAGGGGGCCCAG
CGGGAGATCCAGCTGTGGTTCCAGAGCAGTGAGCTGGTGAGCTGGGCAGACGGGGGCCAG
CACAGCAGCATCCACCCAGCCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
Y07604

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_4_Locus:
16p13.3

# Metabolic_Enzyme_4_SNPs:
rs14293; rs431324; rs763151; rs7185254; rs11248932; rs2071914; rs2363759; rs4984873; rs4984872; rs4984871; rs4984666; rs7188541; rs4399536; rs35267685; rs28676738; rs387290; rs7190051; rs7189866; rs35306680; rs2885894; rs9923794; rs28694736; rs11648458; rs11863625; rs12448825; rs2007351; rs3743890; rs3743894; rs3785290; rs379387; rs3809662; rs3826231; rs3826236; rs390499; rs407983; rs419012; rs436075; rs448063; rs5841; rs734798; rs873477; rs877904; rs8967

# Metabolic_Enzyme_4_General_References:
9099850; 11157797; 10799505

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
6010

# Metabolic_Enzyme_5_Name:
DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide

# Metabolic_Enzyme_5_Synonyms:
RPB6; RPABC14.4; RPB14.4; RPABC2

# Metabolic_Enzyme_5_Gene_Name:
POLR2F

# Metabolic_Enzyme_5_Protein_Sequence:
>DNAdirected RNA polymerases I, II, and III 14.4 kDa polypeptide
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIITD

# Metabolic_Enzyme_5_Number_of_Residues:
127

# Metabolic_Enzyme_5_Molecular_Weight:
14478

# Metabolic_Enzyme_5_Theoretical_pI:
3.84

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  transcription, DNA-dependent
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  protein complex
Component:  RNA polymerase complex

# Metabolic_Enzyme_5_General_Function:
Transcription 

# Metabolic_Enzyme_5_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

# Metabolic_Enzyme_5_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_5_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01192:RNA_pol_Rpb6

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_5_GenBank_ID_Protein:
415388

# Metabolic_Enzyme_5_SwissProt_ID:
RPB6_HUMAN (P61218)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
POLR2F

# Metabolic_Enzyme_5_Geneatlas_id:
POLR2F

# Metabolic_Enzyme_5_hgnc_id:
HGNC:9193

# Metabolic_Enzyme_5_PDB_ID:
1QKL

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_5_Gene_Sequence:
>384 bp
ATGTCAGACAACGAGGACAATTTTGATGGCGACGACTTTGATGATGTGGAGGAGGATGAA
GGGCTAGATGACTTGGAGAATGCCGAAGAGGAAGGCCAGGAGAATGTCGAGATCCTCCCC
TCTGGGGAGCGACCGCAGGCCAACCAGAAGCGAATCACCACACCATACATGACCAAGTAC
GAGCGAGCCCGCGTGCTGGGCACCCGAGCGCTCCAGATTGCGATGTGTGCCCCTGTGATG
GTGGAGCTGGAGGGGGAGACAGATCCTCTGCTCATTGCCATGAAGGAACTCAAGGCCCGA
AAGATCCCCATCATCATTCGCCGTTACCTGCCAGATGGGAGCTATGAAGACTGGGGGGTG
GACGAGCTCATCATCACCGACTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
Z27113

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_5_Locus:
22q13.1

# Metabolic_Enzyme_5_SNPs:
rs139873; rs139866; rs6000958; rs2744978; rs139865; rs139878; rs6000959; rs139872; rs6000954; rs6000960; rs139877; rs6000961; rs6000955; rs6000957; rs139875; rs139876; rs6000956; rs9610884; rs6000963; rs139874; rs11705635; rs9610885; rs12628863; rs3026641; rs35083758; rs11544441; rs11428366; rs1986836; rs34340173; rs139868; rs34987436; rs9607504; rs3026637; rs2733972; rs11298312; rs9610886; rs139867; rs3026639; rs12484412; rs10602151; rs139870; rs139869; rs6000962; rs3026638; rs3026640; rs139862; rs3026636; rs139871; rs139863; rs5995525; rs5995526; rs1053719; rs1053721; rs12158999; rs12166659; rs12170918; rs139859; rs139860; rs139879; rs139880; rs139883; rs139884; rs139885; rs139887; rs2733974; rs3026635; rs3026642; rs3026643; rs3026644; rs35562630; rs5756861; rs5995522; rs5995527; rs6000946; rs6000951; rs7290474; rs8137107; rs9607503; rs9610880; rs9610883; rs9622715

# Metabolic_Enzyme_5_General_References:
7803819; 8786150; 10591208

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
6011

# Metabolic_Enzyme_6_Name:
DNA-directed RNA polymerase III subunit D

# Metabolic_Enzyme_6_Synonyms:
DNA-directed RNA polymerase III 47 kDa polypeptide; RNA polymerase C subunit 4; RPC4; RPC53; Protein BN51

# Metabolic_Enzyme_6_Gene_Name:
POLR3D

# Metabolic_Enzyme_6_Protein_Sequence:
>DNAdirected RNA polymerase III subunit 
DMSEGNAAGEPSTPGGPRPLLTGARGLIGRRPAPPLTPGRLPSIRSRDLTLGGVKKKTFT
PNIISRKIKEEPKEEVTVKKEKRERDRDRQREGHGRGRGRPEVIQSHSIFEQGPAEMMKK
KGNWDKTVDVSDMGPSHIINIKKEKRETDEETKQILRMLEKDDFLDDPGLRNDTRNMPVQ
LPLAHSGWLFKEENDEPDVKPWLAGPKEEDMEVDIPAVKVKEEPRDEEEEAKMKAPPKAA
RKTPGLPKDVSVAELLRELSLTKEEELLFLQLPDTLPGQPPTQDIKPIKTEVQGEDGQVV
LIKQEKDREAKLAENACTLADLTEGQVGKLLIRKSGRVQLLLGKVTLDVTMGTACSFLQE
LVSVGLGDSRTGEMTVLGHVKHKLVCSPDFESLLDHKHR

# Metabolic_Enzyme_6_Number_of_Residues:
398

# Metabolic_Enzyme_6_Molecular_Weight:
44396

# Metabolic_Enzyme_6_Theoretical_pI:
6.97

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

# Metabolic_Enzyme_6_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_6_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF05132:RNA_pol_Rpc4

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_6_GenBank_ID_Protein:
179513

# Metabolic_Enzyme_6_SwissProt_ID:
RPO3D_HUMAN (P05423)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
POLR3D

# Metabolic_Enzyme_6_Geneatlas_id:
POLR3D

# Metabolic_Enzyme_6_hgnc_id:
HGNC:1080

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_6_Gene_Sequence:
>1188 bp
ATGTCGGAAGGAAACGCCGCCGGACGCCCAGCACGGCAGGGCCCGGACCTTCTCCTGACT
GGGGCCCGGGGGTCATCGGGCGGCGGCGGCCTCCCCTCACCCCCGGCCGTTCCCTCCATC
CGTTCCAGGGACCTAACCCTCGGGGGAGTCAAGAAGAAAACCTTCACCCCAAATATCATC
AGTCGGAAGATCAAGGAAGAGCCCAAGGAAGAAGTAACTGTCAAGAAGGAGAAGCGTGAA
AGGGACAGAGACCGACAACGAGAGGGGCATGGACGAGGGCGACGCCGTCCAGAAGTGATC
CAGTCTCACTCCATCTTTGAGCAGGGCCCAGCTGAAATGATGAAGAAAAAAGGGAACTGG
GATAAGACAGTGGATGTGTCAGACATGGGACCTTCTCATATCATCAACATCAAAAAAGAG
AAGAGAGAGACAGACGAAGAAACTAAACAGATCTTGCGTATGCTGGAGAAGGACGATTTC
CTCGATGACCCCGGCCTGAGGAACGACACTCGAAATATGCCTGTGCAGCTGCCGCTGGCT
CACTCAGGATGGCTTTTTAAGGAAGAAAATGACGAACCAGATGTTAAACCTTGGCTGGCT
GGCCCCAAGGAAGAGGACATGGAGGTGGACATACCTGCTGTGAAAGTGAAAGAGGAGCCA
CGAGATGAGGAGGAAGAGGCCAAGATGAAGGCTCCTCCCAAAGCAGCCAGGAAGACTCCA
GGCCTCCCGAAGGATGTATCTGTGGCAGAGCTGCTGAGGGAGCTGAGCCTCACCAAGGAA
GAGGAACTGCTGTTTCTGCAGCTGCCAGACACCCTCCCTGGCCAGCCACCCACCCAGGAC
ATCAAGCCTATCAAGACAGAGGTGCAGGGCGAGGACGGACAGGTGGTGCTCATCAAGCAG
GAGAAAGACCGAGAAGCCAAATTGGCAGAGAATGCTTGTACCCTGGCTGACCTGACAGAG
GGTCAGGTTGGCAAGCTACTCATCCGCAAGTCTGGAAGGGTGCAACTCCTCTTGGGCAAG
GTGACTCTGGACGTGACCATGGGAACTGCCTGCTCCTTCCTGCAGGAGCTGGTGTCCGTG
GGCCTTGGAGACAGTAGGACAGGGGAGATGACAGTCCTGGGACACGTGAAGCACAAACTT
GTATGTTCCCCTGATTTTGAATCCCTCTTGGATCACAAACACCGGTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M17754

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_6_Locus:
8q21

# Metabolic_Enzyme_6_SNPs:
rs1126677; rs2645; rs1126691; rs9173; rs4598250; rs6982634; rs6982901; rs10092957; rs34392777; rs7013112; rs7001492; rs1126676; rs34435413; rs3203560; rs2644; rs34091556; rs7001697; rs34291044; rs34101866; rs4559240; rs4641068; rs34287581; rs35727261; rs35558302; rs11997266; rs12541504; rs12546622; rs13249656; rs13260797; rs4872456; rs4872458; rs7006260; rs7006381

# Metabolic_Enzyme_6_General_References:
3683386; 12391170; 11279001

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5314

# Metabolic_Enzyme_7_Name:
Soluble calcium-activated nucleotidase 1

# Metabolic_Enzyme_7_Synonyms:
SCAN-1; Apyrase homolog; Putative NF-kappa-B-activating protein 107; Putative MAPK-activating protein PM09

# Metabolic_Enzyme_7_Gene_Name:
CANT1

# Metabolic_Enzyme_7_Protein_Sequence:
>Soluble calciumactivated nucleotidase 1
MPVQLSEHPEWNESMHSLRISVGGLPVLASMTKAADPRFRPRWKVILTFFVGAAILWLLC
SHRPAPGRPPTHNAHNWRLGQAPANWYNDTYPLSPPQRTPAGIRYRIAVIADLDTESRAQ
EENTWFSYLKKGYLTLSDSGDKVAVEWDKDHGVLESHLAEKGRGMELSDLIVFNGKLYSV
DDRTGVVYQIEGSKAVPWVILSDGDGTVEKGFKAEWLAVKDERLYVGGLGKEWTTTTGDV
VNENPEWVKVVGYKGSVDHENWVSNYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPR
RASQERYSEKDDERKGANLLLSASPDFGDIAVSHVGAVVPTHGFSSFKFIPNTDDQIIVA
LKSEEDSGRVASYIMAFTLDGRFLLPETKIGSVKYEGIEFI

# Metabolic_Enzyme_7_Number_of_Residues:
401

# Metabolic_Enzyme_7_Molecular_Weight:
44840

# Metabolic_Enzyme_7_Theoretical_pI:
5.98

# Metabolic_Enzyme_7_GO_Classification:
Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP

# Metabolic_Enzyme_7_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_7_Reaction:
A nucleoside diphosphate + H2O = a nucleotide + phosphate

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF06079:Apyrase

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
45-62

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.6.1.6

# Metabolic_Enzyme_7_GenBank_ID_Protein:
22218108

# Metabolic_Enzyme_7_SwissProt_ID:
CANT1_HUMAN (Q8WVQ1)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
CANT1

# Metabolic_Enzyme_7_Geneatlas_id:
CANT1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:19721

# Metabolic_Enzyme_7_PDB_ID:
1S1D

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Intracytoplasmic membrane; single-pass type II membrane protein. Processed form:Secreted protein

# Metabolic_Enzyme_7_Gene_Sequence:
>1116 bp
ATGACCAAGGCCGCGGACCCCCGCTTCCGCCCCCGCTGGAAGGTGATCCTGACGTTCTTT
GTGGGTGCTGCCATCCTCTGGCTGCTCTGCTCCCACCGCCCGGCCCCCGGCAGGCCCCCC
ACCCACAATGCACACAACTGGAGGCTCGGCCAGGCGCCCGCCAACTGGTACAATGACACC
TACCCCCTGTCTCCCCCACAAAGGACACCGGCTGGGATTCGGTATCGAATCGCAGTTATC
GCAGACCTGGACACAGAGTCAAGGGCCCAAGAGGAAAACACCTGGTTCAGTTACCTGAAA
AAGGGCTACCTGACCCTGTCAGACAGTGGGGACAAGGTGGCCGTGGAATGGGACAAAGAC
CATGGGGTCCTGGAGTCCCACCTGGCGGAGAAGGGGAGAGGCATGGAGCTATCCGACCTG
ATTGTTTTCAATGGGAAACTCTACTCCGTGGATGACCGGACGGGGGTCGTCTACCAGATC
GAAGGCAGCAAAGCCGTGCCCTGGGTGATTCTGTCCGACGGCGACGGCACCGTGGAGAAA
GGCTTCAAGGCCGAATGGCTGGCAGTGAAGGACGAGCGTCTGTACGTGGGCGGCCTGGGC
AAGGAGTGGACGACCACTACGGGTGATGTGGTGAACGAGAACCCGGAGTGGGTGAAGGTG
GTGGGCTACAAGGGCAGCGTGGACCACGAGAACTGGGTGTCCAACTACAACGCCCTGCGG
GCTGCTGCCGGCATCCAGCCGCCAGGCTACCTCATCCATGAGTCTGCCTGCTGGAGTGAC
ACGCTGCAGCGCTGGTTCTTCCTGCCGCGCCGCGCCAGCCAGGAGCGCTACAGCGAGAAG
GACGACGAGCGCAAGGGCGCCAACCTGCTGCTGAGCGCCTCCCCTGACTTCGGCGACATC
GCTGTGAGCCACGTCGGGGCGGTGGTCCCCACTCACGGCTTCTCGTCCTTCAAGTTCATC
CCCAACACCGACGACCAGATCATTGTGGCCCTCAAATCCGAGGAGGACAGCGGCAGAGTC
GCCTCCTACATCATGGCCTTCACGCTGGACGGGCGCTTCCTGTTGCCGGAGACCAAGATC
GGAAGCGTGAAATACGAAGGCATCGAGTTCATTTAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AF328554

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_7_Locus:
17q25.3

# Metabolic_Enzyme_7_SNPs:
rs8077024; rs35290882; rs35324359; rs2377301; rs9916285; rs3744171; rs4789903; rs9896857; rs4789848; rs12450407; rs7214331; rs12450128; rs4789847; rs4861; rs11891; rs17739056; rs12452918; rs3744173; rs12949479; rs16971940; rs8079368; rs4789904; rs9904301; rs3744170; rs12452876; rs3744168; rs9915230; rs12452980; rs12451303; rs11546278; rs34082669; rs9903215; rs3803781; rs1127654; rs34461224; rs2377010; rs5017245; rs34435616; rs5017244; rs35308608; rs35755919; rs7219932; rs28627413; rs8078860; rs34996994; rs12936828; rs9899883; rs35356398; rs34938499; rs5017243; rs34572362; rs14791; rs4789849; rs34891215; rs2377009; rs34097366; rs35738150; rs5017242; rs3038740; rs35518955; rs9891726; rs3744169; rs12939358; rs12939350; rs12939399; rs4497730; rs6501274; rs9914188

# Metabolic_Enzyme_7_General_References:
12234496; 12761501; 12167635

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
6012

# Metabolic_Enzyme_8_Name:
DNA-directed RNA polymerase II 140 kDa polypeptide

# Metabolic_Enzyme_8_Synonyms:
RNA polymerase II subunit 2; RPB2

# Metabolic_Enzyme_8_Gene_Name:
POLR2B

# Metabolic_Enzyme_8_Protein_Sequence:
>DNAdirected RNA polymerase II 140 kDa polypeptide
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

# Metabolic_Enzyme_8_Number_of_Residues:
1174

# Metabolic_Enzyme_8_Molecular_Weight:
133898

# Metabolic_Enzyme_8_Theoretical_pI:
6.87

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Transcription 

# Metabolic_Enzyme_8_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

# Metabolic_Enzyme_8_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_8_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF04563:RNA_pol_Rpb2_1;
PF04561:RNA_pol_Rpb2_2;
PF04565:RNA_pol_Rpb2_3;
PF04566:RNA_pol_Rpb2_4;
PF04567:RNA_pol_Rpb2_5;
PF00562:RNA_pol_Rpb2_6;
PF04560:RNA_pol_Rpb2_7

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_8_GenBank_ID_Protein:
36122

# Metabolic_Enzyme_8_SwissProt_ID:
RPB2_HUMAN (P30876)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
POLR2B

# Metabolic_Enzyme_8_Geneatlas_id:
POLR2B

# Metabolic_Enzyme_8_hgnc_id:
HGNC:9188

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_8_Gene_Sequence:
>3525 bp
ATGTACGACGCGGATGAGGATATGCAATATGATGAGGATGATGATGAAATCACCCCGGAT
TTGTGGCAAGAAGCATGCTGGATTGTAATCAGTTCCTATTTTGACGAGAAAGGCTTGGTT
AGACAACAGCTGGATTCTTTTGATGAGTTTATTCAGATGTCTGTTCAAAGAATTGTGGAA
GACGCTCCTCCTATAGACCTACAGGCTGAAGCTCAGCATGCTAGTGGAGAAGTTGAAGAA
CCGCCACGATATTTGCTGAAGTTTGAACAAATTTATCTTTCCAAGCCTACCCATTGGGAA
AGAGATGGTGCTCCTTCACCAATGATGCCCAATGAAGCTAGATTAAGGAATCTCACGTAT
TCTGCTCCGCTTTATGTTGATATAACAAAAACAGTCATTAAAGAAGGTGAAGAACAACTT
CAGACTCAGCATCAGAAAACTTTTATAGGAAAAATTCCAATTATGTTGCGGTCAACTTAC
TGCCTTTTGAATGGCTTGACAGATCGTGATCTTTGTGAGTTAAATGAATGCCCTTTGGAT
CCTGGTGGCTATTTCATTATTAATGGATCAGAAAAGGTTCTGATTGCCCAAGAGAAAATG
GCAACAAACACAGTTTATGTGTTTGCCAAAAAGGATTCTAAATATGCCTACACAGGAGAG
TGTAGATCATGTCTTGAGAATTCTTCCCGACCCACCAGTACTATATGGGTTAGCATGCTG
GCAAGAGGAGGACAGGGTGCCAAGAAGAGTGCTATTGGTCAGCGCATTGTGGCAACTCTA
CCATATATCAAGCAAGAAGTTCCCATCATTATTGTGTTCAGAGCATTAGGTTTTGTGTCC
GACAGAGATATTTTAGAACATATTATTTATGATTTTGAAGATCCAGAGATGATGGAAATG
GTTAAACCTTCTCTCGATGAAGCTTTTGTCATCCAAGAACAGAATGTTGCACTAAATTTC
ATTGGTTCACGAGGAGCAAAGCCTGGTGTTACTAAAGAGAAAAGAATTAAATATGCAAAG
GAAGTTTTACAAAAAGAAATGCTCCCTCATGTTGGTGTCAGTGATTTTTGTGAGACCAAA
AAAGCCTATTTCTTGGGATACATGGTTCATAGGTTACTTCTGGCAGCTTTGGGTAGAAGA
GAACTAGATGACAGAGATCACTATGGAAACAAGAGATTGGATCTTGCTGGGCCGCTGCTT
GCATTCTTATTTAGAGGTATGTTTAAGAATTTGCTTAAAGAAGTGCGGATCTATGCACAG
AAATTTATTGATCGAGGAAAGGATTTTAACTTGGAGTTGGCAATTAAAACACGGATCATA
TCTGATGGCCTAAAATACTCTTTAGCTACTGGAAACTGGGGTGATCAAAAGAAAGCTCAT
CAAGCCAGAGCTGGAGTATCTCAGGTGTTAAACCGCCTGACTTTTGCGTCTACTCTTTCT
CACCTGCGTCGTTTAAATTCTCCTATTGGTAGAGACGGCAAGCTAGCAAAACCAAGACAG
TTGCATAATACGTTGTGGGGAATGGTGTGTCCTGCCGAGACCCCAGAGGGCCATGCTGTA
GGACTTGTGAAGAATTTAGCCTTGATGGCGTATATTTCAGTTGGATCTCAACCATCTCCA
ATTCTGGAATTTTTAGAAGAATGGAGTATGGAAAATTTAGAAGAAATTTCTCCTGCAGCT
ATTGCTGATGCAACCAAGATTTTTGTTAATGGCTGCTGGGTTGGAATACATAAAGATCCC
GAACAACTTATGAACACCCTAAGGAAATTGAGACGTCAGATGGACATCATTGTGTCTGAA
GTTTCTATGATCAGAGATATTCGAGAGAGGGAGATTCGGATCTATACGGATGCAGGCCGT
ATTTGTAGACCACTTCTGATTGTGGAAAAACAAAAGCTACTTTTGAAGAAGAGGCATATT
GACCAATTGAAAGAGAGAGAATATAACAACTATAGTTGGCAGGATCTTGTGGCCAGTGGG
GTAGTGGAGTATATTGATACCCTGGAAGAAGAAACAGTGATGCTTGCAATGACTCCAGAT
GATTTACAGGAGAAAGAAGTAGCTTATTGTTCCACATATACACACTGTGAGATTCATCCC
TCAATGATCCTTGGTGTCTGTGCATCTATTATTCCCTTTCCTGATCATAACCAGTCCCCT
AGAAACACATACCAGTCTGCTATGGGTAAGCAGGCTATGGGAGTTTACATCACCAACTTC
CATGTTCGCATGGACACATTGGCCCATGTTCTCTATTATCCTCAAAAGCCACTTGTGACT
ACACGGTCTATGGAATATCTACGATTTAGAGAGCTGCCAGCAGGCATCAACTCAATTGTG
GCCATTGCATCATACACTGGATATAATCAGGAAGACTCTGTTATCATGAATCGTTCAGCT
GTAGACCGCGGCTTCTTCAGGTCTGTTTTCTATCGCTCATACAAAGAACAGGAGTCTAAA
AAAGGATTTGATCAAGAAGAAGTTTTTGAGAAGCCTACACGTGAAACATGCCAGGGCATG
AGGCATGCCATTTACGACAAGCTGGATGATGATGGTTTGATAGCTCCAGGGGTTCGTGTA
TCAGGAGATGATGTTATTATAGGCAAAACAGTCACCTTGCCTGAAAATGAAGATGAATTG
GAGAGCACCAATAGACGCTATACCAAGAGAGACTGTAGCACTTTTCTCAGAACTAGTGAG
ACGGGCATTGTGGATCAGGTTATGGTAACTCTCAATCAGGAAGGATATAAATTTTGTAAA
ATAAGGGTACGCTCTGTTAGGATTCCACAGATTGGAGACAAATTTGCTAGTCGACATGGT
CAAAAGGGTACTTGTGGTATTCAGTATAGACAAGAGGATATGCCTTTCACCTGTGAAGGT
ATCACCCCTGATATCATCATCAATCCCCATGCCATCCCCTCTCGTATGACTATTGGTCAC
TTAATTGAATGCCTTCAAGGGAAGGTATCGGCTAACAAGGGTGAAATTGGTGATGCCACT
CCATTTAATGATGCTGTTAACGTGCAGAAGATTTCTAATCTTTTATCTGATTATGGCTAT
CATCTCAGAGGAAATGAGGTCCTGTACAATGGGTTCACTGGTCGAAAAATCACATCACAA
ATATTTATTGGCCCCACTTATTACCAGCGTTTGAAGCATATGGTGGATGATAAGATTCAC
TCTCGTGCTAGGGGACCTATTCAGATCCTCAATAGACAGCCCATGGAGGGTAGATCTCGT
GATGGTGGCCTGCGTTTTGGAGAAATGGAACGAGATTGTCAGATTGCCCATGGAGCAGCC
CAGTTTTTAAGGGAAAGATTGTTTGAGGCATCAGATCCATATCAGGTTCATGTTTGCAAT
CTTTGTGGAATAATGGCGATTGCCAACACCAGGACCCATACATATGAATGCAGGGGCTGC
CGCAATAAAACCCAGATTTCTTTGGTGCGAATGCCTTACGCATGCAAACTATTGTTTCAG
GAACTTATGTCTATGAGTATTGCACCGCGAATGATGAGTGTTTAG

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X63563

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_8_Locus:
4q12

# Metabolic_Enzyme_8_SNPs:
rs2271806; rs1056364; rs1718878; rs1713982; rs1403233; rs1277284; rs1718863; rs11732394; rs1718886; rs1277307; rs3775083; rs3821994; rs1277283; rs2293175; rs10018580; rs1277281; rs1277282; rs1718831; rs6843644; rs1277286; rs7440152; rs1277288; rs1718882; rs9918067; rs9997621; rs13146153; rs11133470; rs3733309; rs10034163; rs1718862; rs1718865; rs11731868; rs1614251; rs11735158; rs6843415; rs4865171; rs2412774; rs11930475; rs12650737; rs17087358; rs7659855; rs1277287; rs10002090; rs10026915; rs1718864; rs3796531; rs1718837; rs10023088; rs7661194; rs10461349; rs17087382; rs3796532; rs9994329; rs11936394; rs1626594; rs1718830; rs1718868; rs1608165; rs17087357; rs11940411; rs1401190; rs11947717; rs28719609; rs4865169; rs4864609; rs7685791; rs1630798; rs7684271; rs9991234; rs1713994; rs10033214; rs7676521; rs10002269; rs17081937; rs1718869; rs1277280; rs17828496; rs12512295; rs12498216; rs11727683; rs2412773; rs1718889; rs28570076; rs1713951; rs1713984; rs1713949; rs9685260; rs28666420; rs2271805; rs28681160; rs35477301; rs13121168; rs35987470; rs34594071; rs1713978; rs35232156; rs35127162; rs9997513; rs28474684; rs34749389; rs12506598; rs1277279; rs3733310; rs34177955; rs1713996; rs35530933; rs11315195; rs35534773; rs4865170; rs28742085; rs11406328; rs3037982; rs41560115; rs34081589; rs1299618; rs28623722; rs10018619; rs34601747; rs1315006; rs34255747; rs34153704; rs7692807; rs28561806; rs35370823; rs34855462; rs12508770; rs1718887; rs28391373; rs33990321; rs35779899; rs28370990; rs35463826; rs35275283; rs10000395; rs33967472; rs34791412; rs10016631; rs28581181; rs35489456; rs3775082; rs35863329; rs35927067; rs2687238; rs13145285; rs34804702; rs13121217; rs34784096; rs28658568; rs34948796; rs3841981; rs34538773; rs34568222; rs2948348; rs35323792; rs35276579; rs28568388; rs10025890; rs10034395; rs13121750; rs28367902; rs3839132; rs28545156; rs41554513; rs41556916; rs1315005; rs1718838; rs34000516; rs1718866; rs35009579; rs28620921; rs34205751; rs1277285; rs11331449; rs41547621; rs10018307; rs34666235; rs35667181; rs41552420; rs36211510; rs33978173; rs41553919; rs11133471; rs28409140; rs2687239; rs10029737; rs5858407; rs6834612; rs41549016; rs36042122; rs11310734; rs34125849; rs34739508; rs1612278; rs35706166; rs13109221; rs1713995; rs34549456; rs34756075; rs34158495; rs1277289; rs7675293; rs1718888; rs10023009; rs36007235; rs1713983; rs10653589; rs35386141; rs10011176; rs11934764; rs13148289; rs35985295; rs10030129; rs1107674; rs1107675; rs11133472; rs11133474; rs11553075; rs11573108; rs11573109; rs11573110; rs11573111; rs11573112; rs11573113; rs11573114; rs11573116; rs11573118; rs11573119; rs11573120; rs11573121; rs11573122; rs11573123; rs11573125; rs11573126; rs11573128; rs11573129; rs11573131; rs11573133; rs12621; rs12642622; rs12642627; rs12643733; rs12648928; rs1277310; rs1277311; rs1277312; rs1277313; rs1296633; rs13130169; rs13133792; rs1625691; rs17087332; rs17087335; rs17087401; rs17087411; rs17087414; rs1708759; rs1713990; rs1713997; rs1713998; rs17181222; rs1718824; rs1718833; rs1718885; rs1803937; rs2271808; rs2276896; rs2276897; rs2412772; rs34278765; rs35008546; rs35460070; rs35855328; rs3733306; rs3733307; rs3755903; rs3755904; rs3755905; rs3755906; rs6841086; rs7683519; rs7687211; rs9632

# Metabolic_Enzyme_8_General_References:
1518060; 9110174

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5342

# Metabolic_Enzyme_9_Name:
Nucleoside diphosphate kinase 7

# Metabolic_Enzyme_9_Synonyms:
NDK 7; NDP kinase 7; nm23-H7

# Metabolic_Enzyme_9_Gene_Name:
NME7

# Metabolic_Enzyme_9_Protein_Sequence:
>Nucleoside diphosphate kinase 7
MNHSERFVFIAEWYDPNASLLRRYELLFYPGDGSVEMHDVKNHRTFLKRTKYDNLHLEDL
FIGNKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAISKAGEIIEIINKAGFTI
TKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGPAN
SGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCT
CCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMVT
EMYSGPCVAMEIQQNNATKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLP
EDGLLEVQYFFKILDN

# Metabolic_Enzyme_9_Number_of_Residues:
376

# Metabolic_Enzyme_9_Molecular_Weight:
42492

# Metabolic_Enzyme_9_Theoretical_pI:
6.44

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  nucleoside diphosphate kinase activity
 ||
>>>
Process:  CTP biosynthesis
Process:  nucleoside triphosphate metabolism
Process:  nucleoside triphosphate biosynthesis
Process:  ribonucleoside triphosphate biosynthesis
Process:  pyrimidine ribonucleoside triphosphate biosynthesis
Process:  UTP biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside triphosphate biosynthesis
Process:  purine ribonucleoside triphosphate biosynthesis
Process:  GTP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

# Metabolic_Enzyme_9_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_9_Reaction:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00334:NDK

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.7.4.6

# Metabolic_Enzyme_9_GenBank_ID_Protein:
4960169

# Metabolic_Enzyme_9_SwissProt_ID:
NDK7_HUMAN (Q9Y5B8)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
NME7

# Metabolic_Enzyme_9_Geneatlas_id:
NME7

# Metabolic_Enzyme_9_hgnc_id:
HGNC:20461

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Not Available

# Metabolic_Enzyme_9_Gene_Sequence:
>1131 bp
ATGAATCATAGTGAAAGATTCGTTTTCATTGCAGAGTGGTATGATCCAAATGCTTCACTT
CTTCGACGTTATGAGCTTTTATTTTACCCAGGGGATGGATCTGTTGAAATGCATGATGTA
AAGAATCATCGCACCTTTTTAAAGCGGACCAAATATGATAACCTGCACTTGGAAGATTTA
TTTATAGGCAACAAAGTGAATGTCTTTTCTCGACAACTGGTATTAATTGACTATGGGGAT
CAATATACAGCTCGCCAGCTGGGCAGTAGGAAAGAAAAAACGCTAGCCCTAATTAAACCA
GATGCAATATCAAAGGCTGGAGAAATAATTGAAATAATAAACAAAGCTGGATTTACTATA
ACCAAACTCAAAATGATGATGCTTTCAAGGAAAGAAGCATTGGATTTTCATGTAGATCAC
CAGTCAAGACCCTTTTTCAATGAGCTGATCCAGTTTATTACAACTGGTCCTATTATTGCC
ATGGAGATTTTAAGAGATGATGCTATATGTGAATGGAAAAGACTGCTGGGACCTGCAAAC
TCTGGAGTGGCACGCACAGATGCTTCTGAAAGCATTAGAGCCCTCTTTGGAACAGATGGC
ATAAGAAATGCAGCGCATGGCCCTGATTCTTTTGCTTCTGCGGCCAGAGAAATGGAGTTG
TTTTTTCCTTCAAGTGGAGGTTGTGGGCCGGCAAACACTGCTAAATTTACTAATTGTACC
TGTTGCATTGTTAAACCCCATGCTGTCAGTGAAGGACTGTTGGGAAAGATCCTGATGGCT
ATCCGAGATGCAGGTTTTGAAATCTCAGCTATGCAGATGTTCAATATGGATCGGGTTAAT
GTTGAGGAATTCTATGAAGTTTATAAAGGAGTAGTGACCGAATATCATGACATGGTGACA
GAAATGTATTCTGGCCCTTGTGTAGCAATGGAGATTCAACAGAATAATGCTACAAAGACA
TTTCGAGAATTTTGTGGACCTGCTGATCCTGAAATTGCCCGGCATTTACGCCCTGGAACT
CTCAGAGCAATCTTTGGTAAAACTAAGATCCAGAATGCTGTTCACTGTACTGATCTGCCA
GAGGATGGCCTATTAGAGGTTCAATACTTCTTCAAGATCTTGGATAATTAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AF153191

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_9_Locus:
1q24

# Metabolic_Enzyme_9_SNPs:
rs7538259; rs2176473; rs10494477; rs12057602; rs10800440; rs10919151; rs10919144; rs10919147; rs10800439; rs1208327; rs9628661; rs1209731; rs10919149; rs929132; rs10800433; rs929133; rs1517750; rs4264046; rs12752953; rs17349579; rs16862095; rs3213586; rs7415756; rs10800438; rs12043489; rs7528142; rs12097682; rs7556463; rs1850525; rs1400838; rs10919140; rs10919150; rs3213587; rs1200063; rs12097151; rs10800436; rs11810815; rs10158131; rs16862093; rs12733001; rs16862091; rs10800437; rs12567342; rs4529780; rs4140539; rs16862089; rs12029566; rs12081893; rs9887925; rs6662237; rs7412125; rs17345412; rs1517749; rs12033078; rs17345426; rs6694582; rs4534447; rs6686204; rs12046139; rs12401962; rs10800434; rs1856302; rs7412126; rs10919145; rs12029800; rs11807896; rs12140572; rs16862101; rs12043545; rs10919141; rs4454599; rs10919146; rs16862097; rs12038609; rs10800435; rs12042990; rs4140538; rs10465575; rs2090514; rs2211017; rs909930; rs2143287; rs1419322; rs1358712; rs1024341; rs724049; rs2268048; rs2179492; rs2179491; rs2037250; rs909931; rs1200079; rs1200164; rs10919076; rs10800408; rs7541564; rs3766054; rs12075832; rs10800432; rs3820057; rs3737681; rs3766074; rs12568636; rs3753298; rs1011638; rs9887854; rs12124168; rs12124144; rs2420015; rs958581; rs3753300; rs3766062; rs3820053; rs1419323; rs3766065; rs3820056; rs9988604; rs1018832; rs2420010; rs7518554; rs12130764; rs12564596; rs1208375; rs4656654; rs994986; rs12071277; rs12118611; rs12140967; rs4656655; rs10919084; rs12691502; rs12129969; rs3766084; rs745921; rs6695177; rs6695252; rs12082810; rs1320965; rs3820055; rs2001155; rs10919074; rs3766066; rs4656181; rs3766057; rs1200160; rs1415928; rs10919085; rs10800429; rs724048; rs3766089; rs7541675; rs3753297; rs10919127; rs9887916; rs12117884; rs3766085; rs10919079; rs4656653; rs4656659; rs1320964; rs10800412; rs745922; rs2420016; rs3766060; rs10919075; rs2300157; rs3766063; rs10919116; rs12072226; rs10919093; rs11802143; rs10800411; rs10919128; rs12026996; rs1080268; rs10800418; rs1018831; rs3766086; rs12127305; rs7541700; rs10919134; rs11801853; rs4656661; rs3766077; rs3766071; rs10458388; rs4656665; rs10919124; rs9887857; rs12747242; rs3766059; rs17349222; rs4140540; rs3766075; rs2179490; rs6688038; rs7526337; rs10919110; rs10919090; rs12121994; rs12095171; rs3766083; rs10753786; rs4656177; rs9804101; rs12083287; rs12755385; rs10919129; rs10919115; rs12144832; rs12031371; rs10919087; rs1080267; rs12082618; rs10919092; rs12744184; rs12039443; rs12145146; rs3766053; rs10919114; rs1320967; rs4656662; rs12067072; rs7542713; rs7520186; rs17349460; rs6427180; rs16862081; rs10800421; rs17345170; rs1591734; rs11802239; rs10732287; rs3766067; rs10919118; rs12354315; rs12067018; rs2040446; rs17345156; rs10919122; rs2901030; rs7528751; rs12756799; rs12125501; rs12410548; rs2300158; rs12083075; rs932394; rs17349271; rs2420009; rs11808938; rs10800425; rs12084964; rs7521582; rs17349467; rs10800430; rs12751379; rs4589164; rs12724494; rs12145939; rs1200082; rs2001156; rs17345107; rs3753299; rs3766052; rs12562404; rs3766061; rs7552323; rs12561922; rs4656658; rs4656660; rs1208369; rs7540607; rs1208370; rs1320966; rs4656651; rs909929; rs2300160; rs3766090; rs10800407; rs7521338; rs3766064; rs10919135; rs12120493; rs17349439; rs3766070; rs932395; rs10919082; rs6427179; rs10919120; rs6703463; rs7516097; rs1208373; rs12744655; rs10442644; rs1080266; rs12143193; rs10800424; rs3766069; rs16861990; rs12145897; rs10919086; rs7552484; rs4656656; rs3766082; rs1208377; rs12081283; rs12086983; rs12129979; rs16828170; rs12086665; rs3766076; rs10919123; rs10081959; rs12072953; rs12029857; rs12145226; rs12564558; rs12405725; rs12753710; rs2300159; rs16828165; rs7522760; rs10800431; rs1200086; rs1320968; rs10919088; rs10919099; rs2420014; rs12121346; rs12121185; rs17517699; rs12097793; rs16861993; rs7532362; rs10753785; rs4656178; rs12736886; rs6701686; rs12120007; rs4385775; rs12057856; rs1829286; rs6667882; rs12724093; rs1830492; rs1200076; rs12126266; rs3766094; rs1830494; rs12728466; rs2420008; rs16862058; rs2012757; rs16861997; rs1200161; rs6704482; rs13376083; rs17345184; rs12042082; rs11802117; rs4562680; rs10919130; rs16862077; rs12083249; rs12125921; rs12739920; rs3753293; rs12124064; rs6688139; rs10800415; rs12060959; rs1200084; rs11808274; rs12127613; rs12143965; rs12076469; rs12733626; rs7544446; rs6675220; rs7526721; rs12039104; rs13375997; rs12410456; rs10158265; rs12125985; rs12744341; rs4656669; rs4656657; rs10919111; rs10081960; rs1829287; rs1856303; rs12117559; rs12144705; rs12084549; rs10919105; rs7538158; rs1208371; rs1200073; rs12086292; rs3766078; rs7515326; rs11810319; rs16862000; rs1200085; rs10489417; rs12129132; rs11803007; rs10800410; rs12142784; rs6695674; rs10919104; rs12736110; rs10800417; rs12752748; rs4656666; rs12092528; rs10919089; rs12066375; rs7519735; rs1200077; rs12066426; rs12023291; rs1830493; rs2066001; rs1200083; rs12083296; rs9988595; rs4656180; rs12068152; rs12065226; rs12145969; rs12045202; rs10919119; rs10800406; rs1200162; rs12116683; rs10800414; rs7533349; rs35393101; rs1400840; rs10800423; rs1890260; rs12143131; rs12758208; rs12123168; rs12084957; rs12084793; rs13374340; rs4445529; rs3834009; rs12089118; rs10919132; rs12036968; rs12031830; rs35448601; rs12073439; rs10919102; rs3766079; rs12408636; rs4656652; rs12025566; rs12724802; rs7418266; rs1591733; rs16862051; rs2420012; rs7529937; rs10919078; rs1936533; rs12724863; rs12029428; rs12074013; rs12143135; rs12126032; rs7532255; rs12082748; rs10919095; rs12745997; rs2154125; rs12141917; rs1208374; rs12086569; rs12403181; rs34651513; rs12405185; rs11806445; rs2032044; rs12029853; rs10800420; rs6685384; rs1208376; rs12120960; rs12745732; rs12065030; rs10800413; rs12141151; rs7521964; rs12033035; rs12080100; rs7413522; rs2157597; rs1419324; rs12130858; rs3766088; rs10919108; rs2040445; rs12065884; rs3766055; rs9633334; rs11585212; rs1400839; rs11584076; rs12124744; rs4656664; rs2012763; rs1200080; rs12739337; rs12059281; rs2152980; rs12741540; rs35220898; rs1830495; rs12135928; rs6686006; rs1200075; rs9887903; rs7547686; rs12410241; rs2050119; rs4656179; rs6692824; rs10458394; rs1200081; rs10919094; rs2420011; rs11578912; rs12728614; rs10919101; rs12410387; rs4656668; rs1589113; rs10919106; rs12740040; rs3820054; rs10737545; rs10919133; rs12116551; rs12741323; rs2152979; rs11809256; rs10919136; rs12407865; rs10800419; rs12121395; rs1200074; rs10696699; rs10919142; rs28677096; rs35109195; rs34944961; rs12568544; rs1200060; rs36072396; rs12036426; rs34095348; rs12742330; rs10696698; rs12751929; rs1572616; rs12757669; rs1400837; rs9726842; rs12738217; rs34647634; rs10919143; rs34710865; rs35019256; rs12567068; rs17349586; rs12097260; rs12745541; rs35406371; rs2176474; rs4287233; rs1200064; rs34056724; rs35999944; rs11809378; rs5778612; rs34714244; rs35435858; rs10696697; rs7417281; rs12742459; rs34689938; rs34701797; rs34546589; rs34373126; rs12061080; rs34088496; rs6687062; rs35180550; rs34801027; rs12028433; rs35326875; rs35641779; rs35683059; rs12738248; rs34676722; rs12032783; rs34340382; rs5778613; rs35728129; rs12742460; rs35003708; rs35940727; rs34450667; rs35622699; rs12742307; rs4589163; rs7520046; rs10919148; rs12760656; rs34870158; rs12145350; rs3213585; rs34818994; rs12738203; rs12725912; rs12738211; rs34930817; rs36023090; rs12744362; rs12044982; rs35893899; rs11811461; rs3030219; rs12738256; rs35009499; rs2901032; rs34195074; rs3950167; rs12124738; rs34792089; rs10800428; rs6685857; rs12725542; rs10575933; rs34543492; rs34605921; rs35320565; rs34440651; rs34764111; rs12723742; rs10689301; rs35447001; rs3766068; rs34032351; rs12086104; rs12143790; rs35493809; rs35509277; rs5778607; rs34993736; rs36079696; rs1476065; rs35207260; rs35110010; rs35244822; rs35098610; rs35133990; rs12071302; rs35637907; rs35816758; rs10919109; rs35495283; rs36144136; rs1208368; rs12088527; rs3962194; rs35165011; rs11373823; rs35469833; rs12122348; rs34578296; rs12063719; rs34984299; rs7514729; rs34127028; rs12756556; rs35213162; rs12065826; rs1208287; rs10919083; rs36102044; rs34016668; rs36096137; rs34654692; rs34369716; rs34323371; rs35261574; rs12736817; rs35710695; rs35893113; rs36125519; rs5778603; rs35067189; rs1857567; rs35539429; rs35646253; rs12120344; rs4300284; rs12751062; rs12753699; rs6671966; rs10545228; rs11805562; rs34472735; rs34691590; rs12403013; rs12025233; rs34072833; rs10540645; rs12061405; rs35458577; rs35383178; rs34581963; rs35037551; rs12078340; rs1476063; rs10629320; rs35352275; rs12073338; rs35153537; rs2090513; rs12739381; rs35471075; rs12072404; rs5778610; rs36183681; rs7514582; rs12757427; rs35452880; rs35762400; rs10645332; rs35536594; rs34816984; rs12028197; rs35933108; rs35867722; rs11323879; rs12144230; rs3216527; rs35631014; rs34735555; rs28440806; rs12129567; rs3981316; rs35970886; rs36013240; rs11353985; rs34219745; rs12740205; rs28454510; rs3835442; rs12061279; rs36042457; rs12121788; rs12063056; rs10593825; rs28676800; rs34392894; rs3981317; rs34255929; rs35153249; rs34847919; rs34131734; rs12058325; rs1476064; rs2420013; rs10575934; rs10919098; rs12751804; rs36017709; rs12118918; rs33970981; rs12089602; rs34332810; rs5778602; rs3766072; rs13374428; rs28778909; rs34599560; rs12139905; rs35862763; rs2090512; rs975991; rs16861955; rs12748602; rs35501501; rs3981312; rs35375125; rs12751571; rs35718930; rs718031; rs34033983; rs33951688; rs36179730; rs28738730; rs12030810; rs1211418; rs12133517; rs7529148; rs12071122; rs12072082; rs10919131; rs34123578; rs12070666; rs12117362; rs3962195; rs12081023; rs3981318; rs34997639; rs12750161; rs12126933; rs16861948; rs36010825; rs4567334; rs35144581; rs34235429; rs34246691; rs36056596; rs12743456; rs12730917; rs7548520; rs6703464; rs12753059; rs6679084; rs34750504; rs12753198; rs36176661; rs35091267; rs12044575; rs36040633; rs36061305; rs2901033; rs3835443; rs34577710; rs35527028; rs4656667; rs12738167; rs12067139; rs34178237; rs35653716; rs3835448; rs34962461; rs12038761; rs12076510; rs3060501; rs35658009; rs10686255; rs3766058; rs12736723; rs10919100; rs28648500; rs3060535; rs34218127; rs36013764; rs34215866; rs10800427; rs35272114; rs12048188; rs35606300; rs12035804; rs12743588; rs4497270; rs34408435; rs12081562; rs12071224; rs12758455; rs11267929; rs34975352; rs12030541; rs34254032; rs1208372; rs34313790; rs34089647; rs36047625; rs11446636; rs3766048; rs7537097; rs12068499; rs2095734; rs2227246; rs3060508; rs35586898; rs34276437; rs12740226; rs34794230; rs34985260; rs34376054; rs12758258; rs35983758; rs28495280; rs35396646; rs12735503; rs2066000; rs12735442; rs10919107; rs2187963; rs12039156; rs12751407; rs34669907; rs7555888; rs12759617; rs35977750; rs34473903; rs12061069; rs12725978; rs34809821; rs6664272; rs34877424; rs35416900; rs3981314; rs41442344; rs34222155; rs36189651; rs12118645; rs7522781; rs12140995; rs1999880; rs7533257; rs12750328; rs34748133; rs34576386; rs35423959; rs35497125; rs7532955; rs12063863; rs5778609; rs35092444; rs12730920; rs35870215; rs2138897; rs36140409; rs1200163; rs35680826; rs35625187; rs35000842; rs1209733; rs34492487; rs4614315; rs12047231; rs34253473; rs3981313; rs34481631; rs12724812; rs35834275; rs10800416; rs12076824; rs35470935; rs34611209; rs36040265; rs10919125; rs12144756; rs12027561; rs12143963; rs12753816; rs36103852; rs35682595; rs3766092; rs12729048; rs12074492; rs35735494; rs12049161; rs34923262; rs12743782; rs34342694; rs36083778; rs35952160; rs12401966; rs34087265; rs1208286; rs12038798; rs13374140; rs3981310; rs34240425; rs12735330; rs1200078; rs11295689; rs12088672; rs10919097; rs12085114; rs12723917; rs3981308; rs12744668; rs34994135; rs12040813; rs34829200; rs3766049; rs12041879; rs35639586; rs12728447; rs3835444; rs12068430; rs3981319; rs3835447; rs35093802; rs36192558; rs35686505; rs34848646; rs12760335; rs34194554; rs34240559; rs12740501; rs35232870; rs34693497; rs35973200; rs35816854; rs34527707; rs12734206; rs6691226; rs35271076; rs6685556; rs12062884; rs3060581; rs35784194; rs4471312; rs12093387; rs34419988; rs35763380; rs3820058; rs10919091; rs7533251; rs35127583; rs34062135; rs35320726; rs7522680; rs12142454; rs2268047; rs4284298; rs2187964; rs12145193; rs34748330; rs34248820; rs35956345; rs35758825; rs3962193; rs34882155; rs12125057; rs35870776; rs34054662; rs12735250; rs34990519; rs12045783; rs36154866; rs34147690; rs34364140; rs3981315; rs10579498; rs12045803; rs35249110; rs34732093; rs35877266; rs10919126; rs34250651; rs34176173; rs2901031; rs12731520; rs12087425; rs34830831; rs5778608; rs12070031; rs3835446; rs34848249; rs12745978; rs12748624; rs3937415; rs35159355; rs35295807; rs34889848; rs11359012; rs12738172; rs35977405; rs10158861; rs3981311; rs12076519; rs34926802; rs7533247; rs35346029; rs36175137; rs12734943; rs12067351; rs34627071; rs3831767; rs12757242; rs12063495; rs35524440; rs12760266; rs10550759; rs6698149; rs12752495; rs12753703; rs3766093; rs12086231; rs34321069; rs12021696; rs34469836; rs7514545; rs34045951; rs34417084; rs6686677; rs34903596; rs12037211; rs3981320; rs11410749; rs12086238; rs34973357; rs34754767; rs34758802; rs36186288; rs12735021; rs3981309; rs35503426; rs35774511; rs12066921; rs5778611; rs11589565; rs7519279; rs34417566; rs35119166; rs12118533; rs5778604; rs35997350; rs3835370; rs3766091; rs12739909; rs34165486; rs36013941; rs1028180; rs10494478; rs10800441; rs10919064; rs10919065; rs10919070; rs10919071; rs10919073; rs10919153; rs10919155; rs10919156; rs1138486; rs11800843; rs11809180; rs1200156; rs1200157; rs1200158; rs1200159; rs12022617; rs12023892; rs12024897; rs12026287; rs12035622; rs12038258; rs12070626; rs12084554; rs12091; rs12128543; rs12134211; rs12137282; rs12138150; rs12406083; rs12563090; rs12565299; rs14824; rs1517748; rs1892094; rs1980198; rs2000321; rs2275299; rs2275300; rs2745209; rs2854730; rs2901029; rs3180378; rs3753302; rs3766042; rs3766044; rs3766045; rs3766095; rs3818844; rs4656670; rs4656671; rs6693263; rs7517394; rs7527703; rs7539415; rs7539798; rs7540067; rs7553526; rs968304

# Metabolic_Enzyme_9_General_References:
Not Available

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5346

# Metabolic_Enzyme_10_Name:
Nucleoside diphosphate kinase 6

# Metabolic_Enzyme_10_Synonyms:
NDK 6; NDP kinase 6; nm23-H6; Inhibitor of p53-induced apoptosis-alpha; IPIA-alpha

# Metabolic_Enzyme_10_Gene_Name:
NME6

# Metabolic_Enzyme_10_Protein_Sequence:
>Nucleoside diphosphate kinase 6
MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWRKEDCQRFY
REHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMGPTRVFRARHVAPDSIRGSFG
LTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQLRCGPVCYSPEGGVHYVAGT
GGLGPA

# Metabolic_Enzyme_10_Number_of_Residues:
186

# Metabolic_Enzyme_10_Molecular_Weight:
21142

# Metabolic_Enzyme_10_Theoretical_pI:
8.49

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  nucleoside diphosphate kinase activity
 ||
>>>
Process:  CTP biosynthesis
Process:  nucleoside triphosphate metabolism
Process:  nucleoside triphosphate biosynthesis
Process:  ribonucleoside triphosphate biosynthesis
Process:  pyrimidine ribonucleoside triphosphate biosynthesis
Process:  UTP biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside triphosphate biosynthesis
Process:  purine ribonucleoside triphosphate biosynthesis
Process:  GTP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis

# Metabolic_Enzyme_10_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_10_Reaction:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00334:NDK

# Metabolic_Enzyme_10_Signals:
1-24

# Metabolic_Enzyme_10_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.7.4.6

# Metabolic_Enzyme_10_GenBank_ID_Protein:
3228530

# Metabolic_Enzyme_10_SwissProt_ID:
NDK6_HUMAN (O75414)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
NME6

# Metabolic_Enzyme_10_Geneatlas_id:
NME6

# Metabolic_Enzyme_10_hgnc_id:
HGNC:20567

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Not Available

# Metabolic_Enzyme_10_Gene_Sequence:
>561 bp
ATGGCCTCAATCTTGCGAAGCCCTCAGGCTCTCCAGCTCACTCTAGCCCTGATCAAGCCT
GACGCAGTCGCCCATCCACTGATTCTGGAGGCTGTTCATCAGCAGATTCTAAGCAACAAG
TTCCTGATTGTACGAATGAGAGAACTACTGTGGAGAAAGGAAGATTGCCAGAGGTTTTAC
CGAGAGCATGAAGGGCGTTTTTTCTATCAGAGGCTGGTGGAGTTCATGGCCAGCGGGCCA
ATCCGAGCCTACATCCTTGCCCACAAGGATGCCATCCAGCTCTGGAGGACGCTCATGGGA
CCCACCAGAGTGTTCCGAGCACGCCATGTGGCCCCAGATTCTATCCGTGGGAGTTTCGGC
CTCACTGACACCCGCAACACCACCCATGGTTCGGACTCTGTGGTTTCAGCCAGCAGAGAG
ATTGCAGCCTTCTTCCCTGACTTCAGTGAACAGCGCTGGTATGAGGAGGAAGAGCCCCAG
TTGCGCTGTGGCCCTGTGTGCTATAGCCCAGAGGGAGGTGTCCACTATGTAGCTGGAACA
GGAGGCCTAGGACCAGCCTGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
AF051941

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_10_Locus:
3p21

# Metabolic_Enzyme_10_SNPs:
rs1134867; rs3197223; rs4479622; rs13084616; rs13085251; rs2541; rs13079728; rs34946886; rs13067450; rs4392440; rs4511915; rs13066758; rs4336143; rs7621785; rs35190747; rs34630841; rs13082859; rs35784663; rs11545439; rs1134866; rs28684386; rs35512171; rs34589064; rs34523942; rs34621890; rs34763162; rs34399672; rs35679809; rs9874212; rs10635171; rs7616884; rs5848850; rs36075665; rs13315223; rs34146962; rs35493895; rs34373799; rs34594819; rs34073994; rs35297395; rs13318895; rs34359447; rs4511916; rs6793239; rs6794644; rs6801801; rs6808458; rs7620674; rs7624450; rs7632297; rs9818605; rs9823457; rs9833309; rs9834073; rs9881724

# Metabolic_Enzyme_10_General_References:
10453732

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
6013

# Metabolic_Enzyme_11_Name:
Ethanolamine-phosphate cytidylyltransferase

# Metabolic_Enzyme_11_Synonyms:
Phosphorylethanolamine transferase; CTP:phosphoethanolamine cytidylyltransferase

# Metabolic_Enzyme_11_Gene_Name:
PCYT2

# Metabolic_Enzyme_11_Protein_Sequence:
>Ethanolaminephosphate cytidylyltransferase
MIRNGRGAAGGAEQPGPGGRRAVRVWCDGCYDMVHYGHSNQLRQARAMGDYLIVGVHTDE
EIAKHKGPPVFTQEERYKMVQAIKWVDEVVPAAPYVTTLETLDKYNCDFCVHGNDITLTV
DGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKAHHSSQEMSSEYREYADSFGKC
PGGRNPWTGVSQFLQTSQKIIQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLEKVHRLA
ERPYIIAGLHFDQEVNHYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYAVTAELLSHF
KVDLVCHGKTEIIPDRDGSDPYQEPKRRGIFRQIDSGSNLTTDLIVQRIITNRLEYEARN
QKKEAKELAFLEAARQQAAQPLGERDGDF

# Metabolic_Enzyme_11_Number_of_Residues:
389

# Metabolic_Enzyme_11_Molecular_Weight:
43836

# Metabolic_Enzyme_11_Theoretical_pI:
6.91

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_11_Specific_Function:
CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine

# Metabolic_Enzyme_11_Pathway:
map00440  Aminophosphonate metabolism;
 map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_11_Reaction:
CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF01467:CTP_transf_2

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.7.7.14

# Metabolic_Enzyme_11_GenBank_ID_Protein:
1817548

# Metabolic_Enzyme_11_SwissProt_ID:
PCY2_HUMAN (Q99447)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
PCYT2

# Metabolic_Enzyme_11_Geneatlas_id:
PCYT2

# Metabolic_Enzyme_11_hgnc_id:
HGNC:8756

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Not Available

# Metabolic_Enzyme_11_Gene_Sequence:
>1170 bp
ATGATCCGGAACGGGCGCGGGGCTGCAGGCGGCGCAGAGCAGCCGGGCCCGGGGGGCAGG
CGCGCCGTGAGGGTGTGGTGCGATGGCTGCTATGACATGGTGCATTACGGCCACTCCAAC
CAGCTGCGCCAGGCACGGGCCATGGGTGACTACCTCATCGTAGGCGTGCACACCGATGAG
GAGATCGCCAAGCACAAGGGGCCCCCGGTGTTCACTCAGGAGGAGAGATACAAGATGGTG
CAGGCCATCAAATGGGTGGACGAGGTGGTGCCAGCGGCTCCCTACGTCACTACACTAGAG
ACCCTGGACAAATACAACTGTGACTTCTGTGTTCACGGCAATGACATCACCCTGACTGTA
GATGGCCGGGACACCTATGAGGAAGTAAAGCAGGCTGGGAGGTACAGAGAATGCAAGCGC
ACGCAAGGGGTGTCCACCACAGACCTCGTGGGCCGCATGCTGCTGGTAACCAAAGCCCAT
CACAGCAGCCAGGAGATGTCCTCTGAGTACCGGGAGTATGCAGACAGTTTTGGCAAGTGC
CCTGGTGGGCGGAACCCCTGGACCGGGGTATCCCAGTTCCTGCAGACATCTCAGAAGATC
ATCCAGTTTGCTTCTGGGAAGGAGCCCCAGCCAGGGGAGACAGTCATCTATGTGGCTGGT
GCCTTCGACCTGTTCCACATCGGGCATGTGGACTTCCTGGAGAAGGTGCACAGGCTGGCA
GAGAGGCCCTACATCATCGCGGGCTTACACTTTGACCAGGAGGTCAATCACTACAAGGGG
AAGAACTACCCCATCATGAATCTGCATGAACGGACTCTGAGCGTGCTGGCCTGCCGGTAC
GTGTCAGAAGTGGTGATTGGAGCCCCGTACGCGGTCACAGCAGAGCTCCTAAGTCACTTC
AAGGTGGACCTGGTGTGTCACGGCAAGACAGAAATTATCCCTGACAGGGATGGCTCCGAC
CCATACCAGGAGCCCAAGAGAAGGGGCATCTTCCGTCAGATTGACAGTGGCAGCAACCTC
ACCACAGACCTCATCGTCCAGCGGATCATCACCAACAGGTTGGAGTATGAGGCGCGAAAC
CAGAAGAAGGAAGCCAAGGAGCTGGCCTTCCTGGAGGCTGCCAGGCAGCAGGCGGCACAG
CCCCTGGGGGAGCGCGATGGTGACTTCTAA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
D84307

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_11_Locus:
17q25.3

# Metabolic_Enzyme_11_SNPs:
Not Available

# Metabolic_Enzyme_11_General_References:
9083101

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
6014

# Metabolic_Enzyme_12_Name:
DNA-directed RNA polymerase II largest subunit

# Metabolic_Enzyme_12_Synonyms:
RPB1

# Metabolic_Enzyme_12_Gene_Name:
POLR2A

# Metabolic_Enzyme_12_Protein_Sequence:
>DNAdirected RNA polymerase II largest subunit
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

# Metabolic_Enzyme_12_Number_of_Residues:
1970

# Metabolic_Enzyme_12_Molecular_Weight:
217208

# Metabolic_Enzyme_12_Theoretical_pI:
7.38

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  transcription, DNA-dependent
Process:  transcription from RNA polymerase II promoter
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  protein complex
Component:  RNA polymerase complex
Component:  DNA-directed RNA polymerase II, core complex
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Metabolic_Enzyme_12_General_Function:
Transcription 

# Metabolic_Enzyme_12_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

# Metabolic_Enzyme_12_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_12_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF04997:RNA_pol_Rpb1_1;
PF00623:RNA_pol_Rpb1_2;
PF04983:RNA_pol_Rpb1_3;
PF05000:RNA_pol_Rpb1_4;
PF04998:RNA_pol_Rpb1_5;
PF04992:RNA_pol_Rpb1_6;
PF04990:RNA_pol_Rpb1_7;
PF05001:RNA_pol_Rpb1_R

# Metabolic_Enzyme_12_Signals:
None

# Metabolic_Enzyme_12_Transmembrane_Regions:
None

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_12_GenBank_ID_Protein:
36124

# Metabolic_Enzyme_12_SwissProt_ID:
RPB1_HUMAN (P24928)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
POLR2A

# Metabolic_Enzyme_12_Geneatlas_id:
POLR2A

# Metabolic_Enzyme_12_hgnc_id:
HGNC:9187

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_12_Gene_Sequence:
>5913 bp
ATGCACGGGGGTGGCCCCCCCTCGGGGGACAGCGCATGCCCGCTGCGCACCATCAAGAGA
GTCCAGTTCGGAGTCCTGAGTCCGGATGAACTGAAGCGAATGTCTGTGACGGAGGGTGGC
ATCAAATACCCAGAGACGACTGAGGGAGGCCGCCCCAAGCTTGGGGGGCTGATGGACCCG
AGGCAGGGGGTGATTGAGCGGACTGGCCGCTGCCAAACATGTGCAGGAAACATGACAGAG
TGTCCTGGCCACTTTGGCCACATTGAACTGGCCAAGCCTGTGTTTCACGTGGGCTTCCTG
GTGAAGACAATGAAAGTTTTGCGCTGTGTCTGCTTCTTCTGCTCCAAACTGCTTGTGGAC
TCTAACAACCCAAAGATCAAGGATATCCTGGCTAAGTCCAAGGGACAGCCCAAGAAGCGG
CTCACACATGTCTACGACCTTTGCAAGGGCAAAAACATATGCGAGGGTGGGGAGGAGATG
GACAACAAGTTCGGTGTGGAACAACCTGAGGGTGACGAGGATCTGACCAAAGAAAAGGGC
CATGGTGGCTGTGGGCGGTACCAGCCCAGGATCCGGCGTTCTGGCCTAGAGCTGTATGCG
GAATGGAAGCACGTTAATGAGGACTCTCAGGAGAAGAAGATCCTGCTGAGTCCAGAGCGA
GTGCATGAGATCTTCAAACGCATCTCAGATGAGGAGTGTTTTGTGCTGGGCATGGAGCCC
CGCTATGCACGGCCAGAGTGGATGATTGTCACAGTGCTGCCTGTGCCCCCGCTCTCCGTG
CGGCCTGCTGTTGTGATGCAGGGCTCTGCCCGTAACCAGGATGACCTGACTCACAAACTG
GCTGACATCGTGAAGATCAACAATCAGCTGCGGCGCAATGAGCAGAACGGCGCAGCGGCC
CATGTCATTGCAGAGGATGTGAAGCTCCTCCAGTTCCATGTGGCCACCATGGTGGACAAT
GAGCTGCCTGGCTTGCCCCGTGCCATGCAGAAGTCTGGGCGTCCCCTCAAGTCCCTGAAG
CAGCGGTTGAAGGGCAAGGAAGGCCGGGTGCGAGGGAACCTGATGGGCAAAAGAGTGGAC
TTCTCGGCCCGTACTGTCATCACCCCCGACCCCAACCTCTCCATTGACCAGGTTGGCGTG
CCCCGCTCCATTGCTGCCAACATGACCTTTGCGGAGATTGTCACCCCCTTCAACATTGAC
AGACTTCAAGAACTAGTGCGCAGGGGGAACAGTCAGTACCCAGGCGCCAAGTACATCATC
CGAGACAATGGTGATCGCATTGACTTGCGTTTCCACCCCAAGCCCAGTGACCTTCACCTG
CAGACCGGCTATAAGGTGGAACGGCACATGTGTGATGGGGACATTGTTATCTTCAACCGG
CAGCCAACTCTGCACAAAATGTCCATGATGGGGCATCGGGTCCGCATTCTCCCATGGTCT
ACCTTTCGCTTGAATCTTAGCGTGACAACTCCGTACAATGCAGACTTTGACGGGGATGAG
ATGAACTTGCACCTGCCACAGTCTCTGGAGACGCGAGCAGAGATCCAGGAGCTGGCCATG
GTTCCTCGCATGATTGTCACCCCCCAGAGCAATCGGCCTGTCATGGGTATTGTGCAGGAC
ACACTCACAGCAGTGCGCAAATTCACCAAGAGAGACGTCTTCCTGGAGCGGGGTGAAGTG
ATGAACCTCCTGATGTTCCTGTCGACGTGGGATGGGAAGGTCCCACAGCCGGCCATCCTA
AAGCCCCGGCCCCTGTGGACAGGCAAGCAAATCTTCTCCCTCATCATACCTGGTCACATC
AATTGTATCCGTACCCACAGCACCCATCCCGATGATGAAGACAGTGGCCCTTACAAGCAC
ATCTCTCCTGGGGACACCAAGGTGGTGGTGGAGAATGGGGAGCTGATCATGGGCATCCTG
TGTAAGAAGTCTCTGGGCACGTCAGCTGGCTCCCTGGTCCACATCTCCTACCTAGAGATG
GGTCATGACATCACTCGCCTCTTCTACTCCAACATTCAGACTGTCATTAACAACTGGCTC
CTCATCGAGGGTCATACTATTGGCATTGGGGACTCCATTGCTGATTCTAAGACTTACCAG
GACATTCAGAACACTATTAAGAAGGCCAAGCAGGACGTAATAGAGGTCATCGAGAAGGCA
CACAACAATGAGCTGGAGCCCACCCCAGGGAACACTCTGCGGCAGACGTTTGAGAATCAG
GTGAACCGCATTCTTAACGATGCCCGAGACAAGACTGGCTCCTCTGCTCAGAAATCCCTG
TCTGAATACAACAACTTCAAGTCTATGGTCGTGTCCGGAGCTAAAGGTTCCAAGATTAAC
ATCTCCCAGGTCATTGCTGTCGTTGGACAGCAGAACGTCGAGGGCAAGCGGATTCCATTT
GGCTTCAAGCACCGGACTCTGCCTCACTTCATCAAGGATGACTACGGGCCTGAGAGCCGT
GGCTTTGTGGAGAACTCCTACCTAGCCGGCCTCACACCCACTGAGTTCTTTTTCCACGCC
ATGGGGGGTCGTGAGGGGCTCATTGACACGGCTGTCAAGACTGCTGAGACTGGATACATC
CAGCGGCGGCTGATCAAGTCCATGGAGTCAGTGATGGTGAAGTACGACGCGACTGTGCGG
AACTCCATCAACCAGGTGGTGCAGCTGCGCTACGGCGAAGACGGCCTGGCAGGCGAGAGC
GTTGAGTTCCAGAACCTGGCTACGCTTAAGCCTTCCAACAAGGCTTTTGAGAAGAAGTTC
CGCTTTGATTATACCAATGAGAGGGCCCTGCGGCGCACTCTGCAGGAGGACCTGGTGAAG
GACGTGCTGAGCAACGCACACATCCAGAACGAGTTGGAGCGGGAATTTGAGCGGATGCGG
GAGGATCGGGAGGTGCTCAGGGTCATCTTCCCAACTGGAGACAGCAAGGTCGTCCTCCCC
TGTAACCTGCTGCGGATGATCTGGAATGCTCAGAAAATCTTCCACATCAACCCACGCCTT
CCCTCCGACCTGCACCCCATCAAAGTGGTGGAGGGAGTCAAGGAATTGAGCAAGAAGCTG
GTGATTGTGAATGGGGATGACCCACTAAGTCGACAGGCCCAGGAAAATGCCACGCTGCTC
TTCAACATCCACCTGCGGTCCACGTTGTGTTCCCGCCGCATGGCAGAGGAGTTTCGGCTC
AGTGGGGAGGCCTTCGACTGGCTGCTTGGGGAGATTGAGTCCAAGTTCAACCAAGCCATT
GCGCATCCCGGGGAAATGGTGGGGGCTCTGGCTGCGCAGTCCCTTGGAGAACCTGCCACC
CAGATGACCTTGAATACCTTCCACTATGCTGGTGTGTCTGCCAAGAATGTGACGCTGGGT
GTGCCCCGACTTAAGGAGCTCATCAACATTTCCAAGAAGCCAAAGACTCCTTCGCTTACT
GTCTTCCTGTTGGGCCAGTCCGCTCGAGATGCTGAGAGAGCCAAGGATATTCTGTGCCGT
CTGGAGCATACAACGTTGAGGAAGGTGACTGCCAACACAGCCATCTACTATGACCCCAAC
CCCCAGAGCACGGTGGTGGCAGAGGATCAGGAATGGGTGAATGTCTACTATGAAATGCCT
GACTTTGATGTGGCCCGAATCTCCCCCTGGCTGTTGCGGGTGGAGCTGGATCGGAAGCAC
ATGACTGACCGGAAGCTCACCATGGAGCAGATTGCTGAAAAGATCAATGCTGGTTTTGGT
GACGACTTGAACTGCATCTTTAATGATGACAATGCAGAGAAGCTGGTGCTCCGTATTCGC
ATCATGAACAGCGATGAGAACAAGATGCAAGAGGAGGAAGAGGTGGTGGACAAGATGGAT
GATGATGTCTTCCTGCGCTGCATCGAGTCCAACATGCTGACAGATATGACCCTGCAGGGC
ATCGAGCAGATCAGCAAGGTGTACATGCACTTGCCACAGACAGACAACAAGAAGAAGATC
ATCATCACGGAGGATGGGGAATTCAAGGCCCTGCAGGAGTGGATCCTGGAGACGGACGGC
GTGAGCTTGATGCGGGTGCTGAGTGAGAAGGACGTGGACCCCGTACGCACCACGTCCAAT
GACATTGTGGAGATCTTCACGGTGCTGGGCATTGAAGCCGTGCGGAAGGCCCTGGAGCGG
GAGCTGTACCACGTCATCTCCTTTGATGGCTCCTATGTCAATTACCGACACTTGGCTCTC
TTGTGTGATACCATGACCTGTCGTGGCCACTTGATGGCCATCACCCGACACGGAGTCAAC
CGCCAGGACACAGGACCACTCATGAAGTGTTCCTTTGAGGAAACGGTGGACGTGCTTATG
GAAGCAGCCGCACACGGTGAGAGTGACCCCATGAAGGGGGTCTCTGAGAATATCATGCTG
GGCCAGCTGGCTCCGGCCGGCACTGGCTGCTTTGACCTCCTGCTTGATGCAGAGAAGTGC
AAGTATGGCATGGAGATCCCCACCAATATCCCCGGCCTGGGGGCTGCTGGACCCACCGGC
ATGTTCTTTGGTTCAGCACCCAGTCCCATGGGTGGAATCTCTCCTGCCATGACACCTTGG
AACCAGGGTGCAACCCCTGCCTATGGCGCCTGGTCCCCCAGTGTTGGGAGTGGAATGACC
CCAGGGGCAGCCGGTTTCTCTCCCAGTGCTGCGTCAGATGCCAGCGGCTTCAGCCCAGGT
TACTCCCCTGCCTGGTCTCCCACACCGGGCTCCCCGGGGTCCCCAGGTCCCTCAAGCCCC
TACATCCCTTCACCAGGTGGCGCCATGTCTCCCAGCTACTCGCCAACGTCACCTGCCTAC
GAGCCCCGCTCTCCTGGGGGCTACACACCCCAGAGTCCCTCTTATTCCCCCACTTCACCC
TCCTACTCCCCTACCTCTCCATCCTATTCTCCAACCAGTCCCAACTATAGTCCCACATCA
CCCAGCTATTCGCCAACGTCACCCAGCTACTCACCGACCTCTCCCAGCTACTCACCCACC
TCTCCCAGCTACTCGCCCACCTCTCCCAGCTATTCGCCCACCTCTCCCAGCTACTCACCC
ACTTCCCCTAGCTATTCGCCCACTTCCCCTAGCTACTCGCCAACGTCTCCCAGCTACTCG
CCGACATCTCCCAGCTACTCGCCAACTTCACCCAGCTATTCTCCCACTTCTCCCAGCTAC
TCACCTACCTCTCCAAGCTATTCACCCACCTCCCCCAGCTACTCACCCACTTCCCCAAGT
TACTCACCCACCAGCCCGAACTATTCTCCAACCAGTCCCAATTACACCCCAACATCACCC
AGCTACAGCCCGACATCACCCAGCTATTCCCCTACTAGTCCCAACTACACACCTACCAGC
CCTAACTACAGCCCAACCTCTCCAAGCTACTCTCCAACATCACCCAGCTATTCCCCGACC
TCACCAAGTTACTCCCCTTCCAGCCCACGATACACACCACAGTCTCCAACCTATACCCCA
AGCTCACCCAGCTACAGCCCCAGTTCGCCCAGCTACAGCCCAACCTCACCCAAGTACACC
CCAACCAGTCCTTCTTATAGTCCCAGCTCCCCAGAGTATACCCCAACCTCTCCCAAGTAC
TCACCTACCAGTCCCAAATATTCACCCACCTCTCCCAAGTACTCGCCTACCAGTCCCACC
TATTCACCCACCACCCCAAAATACTCCCCAACATCTCCTACTTATTCCCCAACCTCTCCA
GTCTACACCCCAACCTCTCCCAAGTACTCACCTACTAGCCCCACTTACTCGCCCACTTCC
CCCAAGTACTCGCCCACCAGCCCCACCTACTCGCCCACCTCCCCCAAAGGCTCAACCTAC
TCTCCCACTTCCCCTGGTTACTCGCCCACCAGCCCCACCTACAGTCTCACAAGCCCGGCT
ATCAGCCCGGATGACAGTGACGAGGAGAACTGA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
X63564

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_12_Locus:
17p13.1

# Metabolic_Enzyme_12_SNPs:
rs2301609; rs2228129; rs2228130; rs2228134; rs2228132; rs2228133; rs9894023; rs2071504; rs9898024; rs2228128; rs6761; rs9533; rs4796430; rs8071847; rs8069501; rs9303218; rs11078682; rs4627421; rs7215922; rs8075218; rs2071502; rs8077156; rs3867596; rs3853820; rs12936464; rs2269459; rs7217258; rs7224988; rs8080690; rs11078681; rs9893098; rs2111437; rs10153272; rs6503027; rs3853821; rs9890920; rs3863497; rs11658168; rs2277638; rs4796429; rs4239258; rs9889368; rs9910214; rs2871327; rs9303219; rs9907042; rs11078685; rs7219550; rs9646411; rs11869899; rs11651206; rs6503030; rs3853819; rs11869864; rs6503029; rs10432029; rs8080807; rs9890028; rs4265880; rs4354991; rs7215390; rs25603; rs9890643; rs7215247; rs4796426; rs3216887; rs9906630; rs3826440; rs9911287; rs11650977; rs9892308; rs10153276; rs8070664; rs34151785; rs8071744; rs7225446; rs4796308; rs3833903; rs8076657; rs7217492; rs4450459; rs8067489; rs11658781; rs8076251; rs7225954; rs7215563; rs4407107; rs11869795; rs7214850; rs11652829; rs9899418; rs8074586; rs4632183; rs4796427; rs16956755; rs9989479; rs2229198; rs3198998; rs4344809; rs1058386; rs7219725; rs1135968; rs7217707; rs5030746; rs1058387; rs35457289; rs12603403; rs1058385; rs35980653; rs5030756; rs8753; rs1136004; rs28645553; rs3899670; rs35879612; rs34804711; rs4796432; rs41553814; rs34652317; rs11654972; rs9890935; rs7217015; rs9906913; rs41560516; rs4796428; rs3893462; rs9891153; rs11078686; rs12325773; rs3838885; rs34659383; rs8075482; rs10153278; rs34059368; rs35747300; rs7213657; rs34727588; rs35334589; rs12944480; rs2309751; rs34525088; rs7218412; rs35280224; rs2071503; rs8073473; rs11658706; rs8080503; rs34698159; rs34143066; rs41554719; rs4796431; rs6503028; rs41560014; rs41548112; rs4405609; rs34164024; rs41557313; rs12602203; rs35349856; rs7210258; rs35928501; rs41545340; rs35894069; rs35887841; rs9906433; rs6503026; rs34886649; rs34297747; rs41562419; rs35159839; rs10048219; rs7213878; rs33912917; rs34769383; rs4081676; rs28495247; rs12451900; rs2241234; rs2241235; rs3764434; rs3867594; rs4796309; rs4796420; rs4796421; rs4796422; rs4796424; rs6503025; rs7211392; rs8065577; rs9896516; rs9901161; rs9901643

# Metabolic_Enzyme_12_General_References:
1542581; 7622068; 9671816; 12381297

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
6015

# Metabolic_Enzyme_13_Name:
DNA-directed RNA polymerases III 80 kDa polypeptide

# Metabolic_Enzyme_13_Synonyms:
RNA polymerase III subunit 5; RPC5

# Metabolic_Enzyme_13_Gene_Name:
POLR3E

# Metabolic_Enzyme_13_Protein_Sequence:
>DNAdirected RNA polymerases III 80 kDa polypeptide
MANEEDDPVVQEIDVYLAKSLAEKLYLFQYPVRPASMTYDDIPHLSAKIKPKQQKVELEM
AIDTLNPNYCRSKGEQIALNVDGACADETSTYSSKLMDKQTFCSSQTTSNTSRYAAALYR
QGELHLTPLHGILQLRPSFSYLDKADAKHREREAANEAGDSSQDEAEDDVKQITVRFSRP
ESEQARQRRVQSYEFLQKKHAEEPWVHLHYYGLRDSRSEHERQYLLCPGSSGVENTELVK
SPSEYLMMLMPPSQEEEKDKPVAPSNVLSMAQLRTLPLADQIKILMKNVKVMPFANLMSL
LGPSIDSVAVLRGIQKVAMLVQGNWVVKSDILYPKDSSSPHSGVPAEVLCRGRDFVMWKF
TQSRWVVRKEVATVTKLCAEDVKDFLEHMAVVRINKGWEFILPYDGEFIKKHPDVVQRQH
MLWTGIQAKLEKVYNLVKETMPKKPDAQSGPAGLVCGDQRIQVAKTKAQQNHALLERELQ
RRKEQLRVPAVPPGVRIKEEPVSEEGEEDEEQEAEEEPMDTSPSGLHSKLANGLPLGRAA
GTDSFNGHPPQGCASTPVARELKAFVEATFQRQFVLTLSELKRLFNLHLASLPPGHTLFS
GISDRMLQDTVLAAGCKQILVPFPPQTAASPDEQKVFALWESGDMSDQHRQVLLEIFSKN
YRVRRNMIQSRLTQECGEDLSKQEVDKVLKDCCVSYGGMWYLKGTVQS

# Metabolic_Enzyme_13_Number_of_Residues:
708

# Metabolic_Enzyme_13_Molecular_Weight:
79899

# Metabolic_Enzyme_13_Theoretical_pI:
6.43

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Metabolic_Enzyme_13_General_Function:
Not Available

# Metabolic_Enzyme_13_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters

# Metabolic_Enzyme_13_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_13_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF04801:Sin_N

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
None

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_13_GenBank_ID_Protein:
24429619

# Metabolic_Enzyme_13_SwissProt_ID:
RPC5_HUMAN (Q9NVU0)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
POLR3E

# Metabolic_Enzyme_13_Geneatlas_id:
POLR3E

# Metabolic_Enzyme_13_hgnc_id:
HGNC:30347

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_13_Gene_Sequence:
>2127 bp
ATGGCCAATGAAGAGGATGACCCAGTTGTACAGGAGATCGATGTGTACTTGGCCAAGAGT
CTGGCGGAAAAGCTGTATCTATTTCAGTACCCTGTGCGTCCAGCCTCGATGACCTACGAT
GACATTCCGCACCTCTCAGCCAAGATCAAGCCCAAGCAGCAGAAGGTAGAGCTTGAGATG
GCCATCGACACCCTGAACCCCAACTATTGCCGCAGCAAAGGGGAGCAGATTGCGCTGAAC
GTGGACGGGGCCTGCGCCGACGAGACCAGCACGTATTCCTCGAAGCTGATGGACAAGCAG
ACCTTCTGCTCTTCCCAGACCACCAGTAACACATCCCGTTATGCCGCTGCACTCTACAGG
CAAGGTGAGCTCCACCTGACACCTTTACATGGCATCCTGCAGCTGCGGCCCAGCTTCTCC
TACCTGGATAAGGCTGACGCCAAGCACCGGGAGAGGGAGGCGGCCAACGAGGCAGGGGAC
TCTTCACAGGATGAGGCGGAAGACGATGTTAAGCAGATCACGGTGCGGTTCTCCCGGCCG
GAGTCAGAGCAGGCCCGCCAGCGCCGTGTGCAGTCCTATGAGTTCCTGCAGAAGAAGCAC
GCAGAGGAGCCCTGGGTCCACCTGCATTACTATGGCCTGAGGGACAGTCGCTCTGAGCAT
GAGCGTCAGTACCTGCTGTGCCCCGGCTCAAGCGGGGTGGAGAACACGGAGCTCGTCAAG
TCACCCAGTGAGTACCTGATGATGCTGATGCCACCCAGCCAGGAGGAGGAGAAAGACAAG
CCTGTGGCCCCCAGCAACGTCCTGTCGATGGCCCAGCTGCGCACGCTGCCCCTGGCCGAT
CAGATCAAGATCCTGATGAAGAATGTGAAGGTCATGCCTTTTGCCAACTTGATGAGCCTC
CTGGGCCCCTCCATCGATTCCGTGGCTGTTCTGCGGGGCATCCAGCAGGTGGCGATGTTG
GTCCAAGGGAACTGGGTGGTGAAGAGTGACATCCTATACCCCAAGGACTCGTCCAGCCCT
CACAGCGGCGTGCCTGCTGAGGTGCTCTGCAGGGGCCGAGACTTCGTTATGTGGAAGTTC
ACGCAGAGCCGCTGGGTGGTTAGGAAAGAGGTGGCAACCGTGACCAAACTCTGCGCCGAG
GATGTGAAGGACTTCCTGGAGCACATGGCCGTGGTGAGGATCAACAAAGGCTGGGAGTTC
ATTCTGCCTTATGATGGGGAGTTCATCAAGAAGCACCCGGATGTGGTCCAGCGGCAGCAC
ATGCTGTGGACGGGTATCCAGGCCAAACTGGAAAAAGTCTATAATCTTGTAAAGGAAACC
ATGCCAAAGAAGCCGGATGCACAATCAGGGCCTGCCGGGCTGGTCTGTGGGGACCAGCGG
ATCCAAGTAGCCAAAACCAAGGCCCAGCAGAACCACGCGTTGCTGGAGCGGGAGCTGCAG
CGGCGGAAGGAGCAGCTGCGGGTGCCTGCGGTCCCGCCCGGTGTGCGGATCAAGGAGGAG
CCCGTGAGCGAGGAGGGCGAGGAGGACGAGGAGCAGGAGGCGGAGGAGGAGCCCATGGAC
ACTTCCCCCAGCGGCCTCCACAGCAAGCTGGCCAACGGGCTGCCTCTCGGGCGGGCTGCG
GGCACAGACAGCTTCAACGGGCACCCGCCCCAGGGCTGCGCCAGCACCCCTGTGGCTCGG
GAACTGAAGGCCTTCGTGGAGGCCACCTTTCAGAGACAGTTTGTGCTCACGCTGAGCGAA
CTCAAGCGCCTCTTCAATCTGCACTTGGCCAGCCTGCCCCCCGGCCACACACTCTTCAGC
GGCATCTCGGACCGCATGCTACAGGACACGGTGCTGGCCGCCGGTTGCAAGCAGATACTG
GTGCCTTTTCCCCCCCAGACTGCTGCTTCCCCGGATGAGCAGAAGGTGTTTGCCCTCTGG
GAGTCTGGAGACATGAGTGATCAGCATCGACAGGTTTTGCTTGAAATTTTTTCCAAAAAT
TACCGGGTACGCCGAAACATGATCCAGTCTCGGTTGACTCAAGAGTGTGGAGAAGATCTC
AGTAAACAGGAGGTGGATAAAGTACTAAAGGACTGCTGTGTAAGCTATGGTGGCATGTGG
TACCTTAAAGGGACAGTACAGTCTTGA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
AY092085

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_13_Locus:
16p12.1

# Metabolic_Enzyme_13_SNPs:
rs2347; rs7764; rs9930928; rs7184510; rs13333149; rs9889052; rs9927282; rs11648734; rs12930464; rs9930995; rs7199514; rs8062706; rs2926355; rs8055349; rs11860639; rs7196114; rs4275840; rs12596086; rs9934137; rs2290830; rs8055191; rs2926362; rs12597260; rs11866613; rs12598535; rs3803647; rs12598327; rs11864910; rs2305967; rs12598521; rs9652579; rs16972399; rs16972397; rs4783456; rs11865849; rs16972395; rs12599197; rs13338319; rs11860253; rs9934294; rs17719183; rs12918235; rs9652592; rs11866578; rs28384387; rs28384388; rs2305969; rs28384389; rs9934667; rs34634941; rs35331925; rs34579812; rs7185156; rs2305968; rs2967957; rs35721404; rs35777654; rs34116148; rs17775543; rs9936516; rs35720995; rs34917926; rs36041572; rs34277353; rs11860299; rs35670439; rs35588428; rs4454964; rs34155522; rs2926360; rs35312184; rs2926358; rs2290831; rs10547523; rs34062239; rs34105730; rs35963117; rs34601042; rs11433280; rs35535655; rs2926361; rs35726762; rs34726784; rs2926359; rs35399745; rs12599277; rs34366469; rs4783457; rs4783455; rs2926357; rs35193738; rs10609816; rs34737169; rs12919981; rs9674340; rs10609815; rs35443079; rs9938259; rs28513180; rs10547522; rs2926356; rs28485556; rs9932018; rs35826273; rs35203065; rs34389358; rs2926353; rs2926354; rs1185336; rs12923248; rs12923079; rs28691226; rs28620720; rs35575145; rs1133616; rs11866996; rs12449036; rs12596547; rs12596884; rs12599010; rs12935126; rs35532058; rs4254316; rs8054951; rs8064050; rs9922647; rs9922693; rs9924003; rs9925872

# Metabolic_Enzyme_13_General_References:
12391170; 10819331

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5636

# Metabolic_Enzyme_14_Name:
N-acylneuraminate cytidylyltransferase

# Metabolic_Enzyme_14_Synonyms:
CMP-N- acetylneuraminic acid synthetase; CMP-NeuNAc synthetase

# Metabolic_Enzyme_14_Gene_Name:
CMAS

# Metabolic_Enzyme_14_Protein_Sequence:
>Nacylneuraminate cytidylyltransferase
MDSVEKGAATSVSNPRGRPSRGRPPKLQRNSRGGQGRGVEKPPHLAALILARGGSKGIPL
KNIKHLAGVPLIGWVLRAALDSGAFQSVWVSTDHDEIENVAKQFGAQVHRRSSEVSKDSS
TSLDAIIEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQFRW
SEIQKGVREVTEPLNLNPAKRPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEM
RAEHSVDIDVDIDWPIAEQRVLRYGYFGKEKLKEIKLLVCNIDGCLTNGHIYVSGDQKEI
ISYDVKDAIGISLLKKSGIEVRLISERACSKQTLSSLKLDCKMEVSVSDKLAVVDEWRKE
MGLCWKEVAYLGNEVSDEECLKRVGLSGAPADACSTAQKAVGYICKCNGGRGAIREFAEH
ICLLMEKVNNSCQK

# Metabolic_Enzyme_14_Number_of_Residues:
434

# Metabolic_Enzyme_14_Molecular_Weight:
48380

# Metabolic_Enzyme_14_Theoretical_pI:
8.02

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  carbohydrate biosynthesis
Process:  polysaccharide biosynthesis
Process:  lipopolysaccharide biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Not Available

# Metabolic_Enzyme_14_Specific_Function:
Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN)

# Metabolic_Enzyme_14_Pathway:
map00530  Aminosugars metabolism

# Metabolic_Enzyme_14_Reaction:
CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF02348:CTP_transf_3

# Metabolic_Enzyme_14_Signals:
None

# Metabolic_Enzyme_14_Transmembrane_Regions:
None

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 2.7.7.43

# Metabolic_Enzyme_14_GenBank_ID_Protein:
22085790

# Metabolic_Enzyme_14_SwissProt_ID:
NEUA_HUMAN (Q8NFW8)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
CMAS

# Metabolic_Enzyme_14_Geneatlas_id:
CMAS

# Metabolic_Enzyme_14_hgnc_id:
HGNC:18290

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_14_Gene_Sequence:
>1305 bp
ATGGACTCGGTGGAGAAGGGGGCCGCCACCTCCGTCTCCAACCCGCGGGGGCGACCGTCC
CGGGGCCGGCCGCCGAAGCTGCAGCGCAACTCTCGCGGCGGCCAGGGCCGAGGTGTGGAG
AAGCCCCCGCACCTGGCAGCCCTAATTCTGGCCCGGGGAGGCAGCAAAGGCATCCCCCTG
AAGAACATTAAGCACCTGGCGGGGGTCCCGCTCATTGGCTGGGTCCTGCGTGCGGCCCTG
GATTCAGGGGCCTTCCAGAGTGTATGGGTTTCGACAGACCATGATGAAATTGAGAATGTG
GCCAAACAATTTGGTGCACAAGTTCATCGAAGAAGTTCTGAAGTTTCAAAAGACAGCTCT
ACCTCACTAGATGCCATCATAGAATTTCTTAATTATYATAATGAGGKTGACATTGTAGGA
AATATTCAAGCTACTTCTYCATGTTTACATCCTACTGATCTTCAAAAAGTTGCAGAAATG
ATTCGAGAAGAAGGATATGATTCTGKTTTCTCTGTTGTGAGACGCCATCAGTTTCGATGG
AGTGAAATTCAGAAAGGAGTTCGTGAAGTGACCGAACCTCTGAATTTAAATCCAGCTAAA
CGGCCTCGTCGACAAGACTGGGATGGAGAATTATATGAAAATGGCTCATTTTATTTTGCT
AAAAGACATTTGATAGAGATGGGTTACTTGCAGGGTGGAAAAATGGCATACTACGAAATG
CGAGCTGAACATAGTGTGGATATAGATGTGGATATTGATTGGCCTATTGCAGAGCAAAGA
GTATTAAGATATGGCTATTTTGGCAAAGAGAAGCTTAAGGAAATAAAACTTTTGGTTTGC
AATATTGATGGATGTCTCACCAATGGCCACATTTATGTATCAGGAGACCAAAAAGAAATA
ATATCTTATGATGTAAAAGATGCTATTGGGATAAGTTTATTAAAGAAAAGTGGTATTGAG
GTGAGGCTAATCTCAGAAAGGGCCTGTTCAAAGCAGACGCTGTCTTCTTTAAAACTGGAT
TGCAAAATGGAAGTCAGTGTATCAGACAAGCTAGCAGTTGTAGATGAATGGAGAAAAGAA
ATGGGCCTGTGCTGGAAAGAAGTGGCATATCTTGGAAATGAAGTGTCTGATGAAGAGTGC
TTGAAGAGAGTGGGCCTAAGTGGCGCTCCTGCTGATGCCTGTTCCTACGCCCAGAAGGCT
GTTGGATACATTTGCAAATGTAATGGTGGCCGTGGTGCCATCCGAGAATTTGCAGAGCAC
ATTTGCCTACTAATGGAAAAAGTTAATAATTCATGCCAAAAATAG

# Metabolic_Enzyme_14_GenBank_ID_Gene:
AF397212

# Metabolic_Enzyme_14_Chromosome_Location:
Not Available

# Metabolic_Enzyme_14_Locus:
Not Available

# Metabolic_Enzyme_14_SNPs:
Not Available

# Metabolic_Enzyme_14_General_References:
Not Available

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5341

# Metabolic_Enzyme_15_Name:
Nucleoside diphosphate kinase A

# Metabolic_Enzyme_15_Synonyms:
NDK A; NDP kinase A; Tumor metastatic process-associated protein; Metastasis inhibition factor nm23; nm23-H1; Granzyme A-activated DNase; GAAD

# Metabolic_Enzyme_15_Gene_Name:
NME1

# Metabolic_Enzyme_15_Protein_Sequence:
>Nucleoside diphosphate kinase 
AMANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRP
FFAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHG
SDSVESAEKEIGLWFHPEELVDYTSCAQNWIYE

# Metabolic_Enzyme_15_Number_of_Residues:
152

# Metabolic_Enzyme_15_Molecular_Weight:
17149

# Metabolic_Enzyme_15_Theoretical_pI:
6.11

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  nucleoside diphosphate kinase activity
 ||
>>>
Process:  CTP biosynthesis
Process:  nucleoside triphosphate metabolism
Process:  nucleoside triphosphate biosynthesis
Process:  ribonucleoside triphosphate biosynthesis
Process:  pyrimidine ribonucleoside triphosphate biosynthesis
Process:  UTP biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside triphosphate biosynthesis
Process:  purine ribonucleoside triphosphate biosynthesis
Process:  GTP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_15_Specific_Function:
Major role in the synthesis of nucleoside triphosphates other than ATP

# Metabolic_Enzyme_15_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_15_Reaction:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00334:NDK

# Metabolic_Enzyme_15_Signals:
None

# Metabolic_Enzyme_15_Transmembrane_Regions:
None

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 2.7.4.6

# Metabolic_Enzyme_15_GenBank_ID_Protein:
35068

# Metabolic_Enzyme_15_SwissProt_ID:
NDKA_HUMAN (P15531)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
NME1

# Metabolic_Enzyme_15_Geneatlas_id:
NME1

# Metabolic_Enzyme_15_hgnc_id:
HGNC:7849

# Metabolic_Enzyme_15_PDB_ID:
1JXV

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Cytoplasm. Nucleus

# Metabolic_Enzyme_15_Gene_Sequence:
>543 bp
TGCTGCGAACCACGTGGGTCCCGGGCGCGTTTCGGGTGCTGGCGGCTGCAGCCGGAGTTC
AAACCTAAGCAGCTGGAAGGAACCATGGCCAACTGTGAGCGTACCTTCATTGCGATCAAA
CCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGA
TTCCGCCTTGTTGGTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTAC
GTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCG
GTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGG
GAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTT
GGCAGGAACATTATACATGGCAGTGATTCTGTGGAGAGTGCAGAGAAGGAGATCGGCTTG
TGGTTTCACCCTGAGGAACTGGTAGATTACACGAGCTGTGCTCAGAACTGGATCTATGAA
TGA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
X17620

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_15_Locus:
17q21.3

# Metabolic_Enzyme_15_SNPs:
Not Available

# Metabolic_Enzyme_15_General_References:
2509941; 8270257; 7916650; 1851158; 2056128; 10512675; 11835509; 12972261; 12628186; 8047138

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
6016

# Metabolic_Enzyme_16_Name:
DNA-directed RNA polymerase II subunit J

# Metabolic_Enzyme_16_Synonyms:
DNA-directed RNA polymerase II 13.3 kDa polypeptide; RPB11

# Metabolic_Enzyme_16_Gene_Name:
POLR2J

# Metabolic_Enzyme_16_Protein_Sequence:
>DNAdirected RNA polymerase II subunit 
JMNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFA
GYKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

# Metabolic_Enzyme_16_Number_of_Residues:
117

# Metabolic_Enzyme_16_Molecular_Weight:
13293

# Metabolic_Enzyme_16_Theoretical_pI:
5.68

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  protein binding
Function:  protein dimerization activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Transcription 

# Metabolic_Enzyme_16_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

# Metabolic_Enzyme_16_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_16_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF01193:RNA_pol_L

# Metabolic_Enzyme_16_Signals:
None

# Metabolic_Enzyme_16_Transmembrane_Regions:
None

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_16_GenBank_ID_Protein:
4165267

# Metabolic_Enzyme_16_SwissProt_ID:
RPO2J_HUMAN (P52435)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
POLR2J

# Metabolic_Enzyme_16_Geneatlas_id:
POLR2J

# Metabolic_Enzyme_16_hgnc_id:
HGNC:9197

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_16_Gene_Sequence:
>354 bp
ATGAACGCCCCTCCAGCCTTCGAGTCGTTCTTGCTCTTCGAGGGCGAGAAGAAGATCACC
ATTAACAAGGACACCAAGGTACCCAATGCCTGTTTATTCACCATCAACAAAGAAGACCAC
ACACTGGGAAACATCATTAAATCACAACTCCTAAAAGACCCGCAAGTGCTATTTGCTGGC
TACAAAGTCCCCCACCCCTTGGAGCACAAGATCATCATCCGAGTGCAGACCACGCCGGAC
TACAGCCCCCAGGAAGCCTTTACCAACGCCATCACCGACCTCATCAGTGAGCTGTCCCTG
CTGGAGGAGCGCTTTCGGGTGGCCATAAAAGACAAGCAGGAAGGAATTGAGTAG

# Metabolic_Enzyme_16_GenBank_ID_Gene:
X82385

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_16_Locus:
7q11.2

# Metabolic_Enzyme_16_SNPs:
rs4556028; rs9691424; rs9692124; rs11157; rs1131325; rs4358740; rs35054682; rs4729793; rs34036426; rs35002684; rs34808331; rs9691416; rs28469551; rs7794729; rs10249943; rs10953369; rs1131359; rs1131383; rs1131384; rs11538919; rs11761361; rs11975935; rs12381; rs12533485; rs12533649; rs12534296; rs12534337; rs12538735; rs13223494; rs34048535; rs35310665; rs3800987; rs3800988; rs3823658; rs4077770; rs4473948; rs4552831; rs4727526; rs4729791

# Metabolic_Enzyme_16_General_References:
8797801; 9201987; 12853948; 10783144

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
6017

# Metabolic_Enzyme_17_Name:
DNA-directed RNA polymerase, mitochondrial precursor

# Metabolic_Enzyme_17_Synonyms:
MtRPOL

# Metabolic_Enzyme_17_Gene_Name:
POLRMT

# Metabolic_Enzyme_17_Protein_Sequence:
>DNAdirected RNA polymerase, mitochondrial precursor
MSALCWGRGAAGLKRALRPCGRPGLPGKEGTAGGVCGPRRSSSASPQEQDQDRRKDWGHV
ELLEVLQARVRQLQAESVSEVVVNRVDVARLPECGSGDGSLQPPRKVQMGAKDATPVPCG
RWAKILEKDKRTQQMRMQRLKAKLQMPFQSGEFKALTRRLQVEPRLLSKQMAGCLEDCTR
QAPESPWEEQLARLLQEAPGKLSLDVEQAPSGQHSQAQLSGQQQRLLAFFKCCLLTDQLP
LAHHLLVVHHGQRQKRKLLTLDMYNAVMLGWARQGAFKELVYVLFMVKDAGLTPDLLSYA
AALQCMGRQDQDAGTIERCLEQMSQEGLKLQALFTAVLLSEEDRATVLKAVHKVKPTFSL
PPQLPPPVNTSKLLRDVYAKDGRVSYPKLHLPLKTLQCLFEKQLHMELASRVCVVSVEKP
TLPSKEVKHARKTLKTLRDQWEKALCRALRETKNRLEREVYEGRFSLYPFLCLLDEREVV
RMLLQVLQALPAQGESFTTLARELSARTFSRHVVQRQRVSGQVQALQNHYRKYLCLLASD
AEVPEPCLPRQYWEELGAPEALREQPWPLPVQMELGKLLAEMLVQATQMPCSLDKPHRSS
RLVPVLYHVYSFRNVQQIGILKPHPAYVQLLEKAAEPTLTFEAVDVPMLCPPLPWTSPHS
GAFLLSPTKLMRTVEGATQHQELLETCPPTALHGALDALTQLGNCAWRVNGRVLDLVLQL
FQAKGCPQLGVPAPPSEAPQPPEAHLPHSAAPARKAELRRELAHCQKVAREMHSLRAEAL
YRLSLAQHLRDRVFWLPHNMDFRGRTYPCPPHFNHLGSDVARALLEFAQGRPLGPHGLDW
LKIHLVNLTGLKKREPLRKRLAFAEEVMDDILDSADQPLTGRKWWMGAEEPWQTLACCME
VANAVRASDPAAYVSHLPVHQDGSCNGLQHYAALGRDSVGAASVNLEPSDVPQDVYSGVA
AQVEVFRRQDAQRGMRVAQVLEGFITRKVVKQTVMTVVYGVTRYGGRLQIEKRLRELSDF
PQEFVWEASHYLVRQVFKSLQEMFSGTRAIQHWLTESARLISHMGSVVEWVTPLGVPVIQ
PYRLDSKVKQIGGGIQSITYTHNGDISRKPNTRKQKNGFPPNFIHSLDSSHMMLTALHCY
RKGLTFVSVHDCYWTHAADVSVMNQVCREQFVRLHSEPILQDLSRFLVKRFCSEPQKILE
ASQLKETLQAVPKPGAFDLEQVKRSTYFFS

# Metabolic_Enzyme_17_Number_of_Residues:
1230

# Metabolic_Enzyme_17_Molecular_Weight:
138622

# Metabolic_Enzyme_17_Theoretical_pI:
9.25

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Not Available

# Metabolic_Enzyme_17_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

# Metabolic_Enzyme_17_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_17_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF00940:RNA_pol

# Metabolic_Enzyme_17_Signals:
None

# Metabolic_Enzyme_17_Transmembrane_Regions:
None

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_17_GenBank_ID_Protein:
2114396

# Metabolic_Enzyme_17_SwissProt_ID:
RPOM_HUMAN (O00411)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
POLRMT

# Metabolic_Enzyme_17_Geneatlas_id:
POLRMT

# Metabolic_Enzyme_17_hgnc_id:
HGNC:9200

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_17_Gene_Sequence:
>3693 bp
ATGTCGGCACTTTGCTGGGGCCGCGGAGCGGCGGGGCTCAAACGAGCCCTACGGCCTTGC
GGCCGCCCGGGACTCCCCGGCAAAGAAGGGACCGCCGGTGGCGTCTGCGGCCCCAGGAGG
AGCTCGTCCGCCAGCCCCCAGGAGCAAGACCAAGACCGCAGGAAGGACTGGGGCCACGTG
GAGCTGCTGGAGGTGCTCCAGGCGCGGGTGCGGCAGCTGCAGGCTGAGAGCGTGTCGGAG
GTGGTGGTGAACAGGGTGGATGTGGCGCGGCTCCCAGAATGTGGCAGTGGAGATGGTAGC
CTCCAGCCACCCAGGAAGGTCCAGATGGGGGCCAAGGATGCCACCCCGGTGCCCTGTGGC
CGCTGGGCAAAGATACTGGAGAAGGATAAGCGGACCCAGCAGATGCGTATGCAGCGGTTG
AAGGCGAAGCTGCAGATGCCATTCCAGAGCGGGGAGTTCAAGGCGCTGACCAGGCGCCTG
CAGGTGGAGCCCCGGCTCCTGAGCAAGCAGATGGCCGGGTGCCTGGAGGACTGCACGCGC
CAGGCCCCCGAGAGCCCCTGGGAGGAGCAGCTGGCCCGGCTGCTGCAGGAGGCCCCTGGG
AAGCTGAGCCTCGATGTGGAGCAGGCCCCGTCGGGGCAGCACTCGCAGGCCCAGCTCTCA
GGTCAGCAGCAGAGGCTCCTGGCCTTCTTCAAGTGCTGCCTGCTCACTGACCAGCTGCCC
CTCGCCCACCACCTGCTGGTCGTCCACCACGGCCAGCGGCAGAAGCGGAAGCTGCTCACG
CTGGACATGTACAACGCCGTGATGCTTGGCTGGGCGCGGCAGGGTGCTTTCAAGGAGCTG
GTATATGTGTTATTCATGGTGAAGGATGCCGGCTTGACCCCGGACCTGCTGTCCTATGCG
GCTGCCCTCCAGTGCATGGGGAGGCAGGACCAGGACGCCGGGACCATCGAAAGGTGTCTG
GAACAGATGAGCCAGGAGGGGCTGAAGCTGCAGGCACTCTTCACCGCCGTTCTGCTGTCT
GAGGAGGATCGGGCCACTGTTCTGAAGGCCGTGCACAAGGTGAAGCCCACCTTCAGCCTC
CCGCCGCAGCTGCCGCCCCCGGTCAACACCTCCAAGCTGCTCAGGGACGTGTATGCCAAG
GATGGGCGTGTGTCCTACCCGAAGCTGCACCTGCCCTTGAAGACCCTGCAGTGCTTCTTT
GAGAAGCAGCTCCACATGGAGCTGGCCAGCAGGGTGTGCGTGGTGTCCGTGGAGAAGCCC
ACGTTGCCAAGCAAGGAGGTCAAGCACGCGCGGAAGACCCTGAAGACCCTGCGGGACCAA
TGGGAGAAAGCACTGTGCCGGGCGCTGCGGGAGACCAAGAACCGCCTAGAGCGCGAGGTG
TACGAGGGCCGGTTCTCACTTTACCCCTTCCTGTGCCTGCTGGACGAGCGCGAGGTGGTG
CGGATGCTCCTGCAGGTCCTGCAGGCGCTGCCCGCCCAAGGTGAGTCCTTCACCACCCTG
GCCCGGGAGCTGAGTGCGCGCACTTTCAGCCGGCACGTGGTGCAGAGGCAGCGGGTCAGT
GGCCAGGTGCAGGCGCTGCAGAACCACTACAGGAAGTACCTCTGCTTGCTGGCCTCCGAC
GCCGAGGTGCCCGAGCCCTGCCTGCCGCGGCAGTACTGGGAGGAGCTGGGGGCGCCCGAG
GCCCTGCGGGAGCAGCCCTGGCCCCTGCCAGTGCAGATGGAGCTGGGCAAGCTGCTGGCG
GAGATGCTGGTGCAGGCTACGCAGATGCCATGCAGCCTGGACAAGCCGCATCGTTCCTCT
CGGCTTGTCCCCGTGCTCTACCACGTGTATTCCTTCCGCAACGTCCAGCAAATCGGCATC
CTGAAGCCGCACCCGGCCTACGTGCAGCTGCTGGAGAAGGCCGCGGAACCCACGCTGACC
TTCGAGGCGGTGGATGTACCCATGCTTTGCCCCCCGCTGCCCTGGACATCGCCGCACTCT
GGTGCTTTCCTGCTCAGCCCCACCAAGCTGATGCGCACGGTGGAAGGCGCCACGCAACAC
CAGGAGCTGCTGGAAACCTGCCCACCCACCGCGCTGCATGGCGCACTGGACGCCCTCACC
CAACTGGGCAACTGCGCCTGGCGCGTCAACGGGCGCGTGCTGGACCTGGTGCTGCAGCTC
TTCCAGGCCAAGGGCTGCCCCCAGCTAGGCGTGCCGGCCCCGCCCTCCGAGGCGCCCCAG
CCGCCCGAGGCCCACCTGCCGCACAGCGCCGCGCCCGCCCGCAAGGCCGAGCTGCGCCGT
GAGCTGGCGCACTGCCAGAAGGTGGCCCGGGAGATGCACAGCCTGCGGGCGGAGGCGCTG
TACCGCCTCTCGCTGGCGCAGCACCTGCGGGACCGCGTCTTCTGGCTGCCGCACAACATG
GACTTCCGCGGCCGCACCTACCCCTGCCCGCCGCACTTCAACCACCTGGGCAGCGACGTG
GCGCGGGCCCTGCTGGAGTTCGCCCAGGGCCGCCCGCTCGGCCCGCACGGCCTGGATTGG
CTCAAGATCCACCTGGTCAATCTCACGGGGTTGAAGAAGCGGGAGCCGCTGCGGAAGCGC
CTGGCCTTTGCGGAGGAGGTGATGGATGACATCCTGGACTCCGCGGACCAACCCTTGACG
GGCCGAAAGTGGTGGATGGGCGCGGAGGAACCCTGGCAGACGCTGGCCTGCTGTATGGAG
GTGGCGAACGCTGTGCGCGCCTCCGACCCTGCCGCCTATGTCTCCCACCTCCCCGTCCAT
CAGGACGGCTCTTGCAACGGCCTGCAGCATTATGCTGCTCTGGGCCGCGACAGCGTGGGC
GCCGCCTCCGTCAACCTGGAGCCCTCGGATGTGCCGCAGGACGTGTACAGCGGCGTGGCC
GCGCAGGTGGAGGTGTTCCGTAGGCAGGACGCCCAGCGGGGCATGCGGGTGGCACAGGTG
CTGGAAAGTTTCATCACCCGCAAGGTGGTGAAGCAGACGGTGATGACGGTGGTGTACGGG
GTCACGCGCTATGGCGGGCGCCTGCAGATTGAGAAGCGCCTCCGGGAGCTGAGCGACTTT
CCCCAGGAGTTCGTGTGGGAGGCCTCTCACTATCTCGTACGCCAGGTCTTCAAGAGTCTA
CAGGAGATGTTCTCGGGGACCCGGGCCATCCAGCACTGGCTGACCGAGAGTGCCCGCCTC
ATCTCCCACATGGGCTCTGTGGTGGAGTGGGTCACACCCCTGGGCGTCCCCGTCATCCAG
CCGTATCGCCTGGACTCCAAGGTCAAGCAAATAGGAGGTGGAATTCAGAGCATCACCTAC
ACCCACAACGGAGACATCAGCCGAAAGCCCAACACACGTAAGCAGAAGAACGGCTTCCCG
CCCAACTTCATCCACTCGCTGGACTCCTCCCACATGATGCTCACCGCCCTGCACTGCTAC
AGGAAGGGCCTGACCTTCGTCTCTGTGCACGACTGTTACTGGACTCACGCAGCTGATGTC
TCCGTCATGAACCAGGTGTGCCGGGAGCAGTTTGTCCGCTTGCACAGCGAGCCCATCCTG
CAGGACCTGTCCAGATTCCTGGTCAAGCGGTTCTGCTCTGAGCCCCAGAAGATCTTGGAG
GCCAGCCAGCTGAAGGAGACACTGCAGGCGGTGCCCAAGCCAGGGGCCTTCGACCTGGAG
CAGGTGAAGCGTTCCACCTACTTCTTCAGCTGA

# Metabolic_Enzyme_17_GenBank_ID_Gene:
U75370

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_17_Locus:
19p13.3

# Metabolic_Enzyme_17_SNPs:
rs2238549; rs12610885; rs11669141; rs1056766; rs2238547; rs11550305; rs2238548; rs2285855; rs11672829; rs2017580; rs9304924; rs2283576; rs11669381; rs1859268; rs11085148; rs2283575; rs2074548; rs10419855; rs2283577; rs2285853; rs12611142; rs12460106; rs2238550; rs1609755; rs3815110; rs11668261; rs12609008; rs11669897; rs12609122; rs12611157; rs10853989; rs11669858; rs12610820; rs10853990; rs2285854; rs11669180; rs9304925; rs12610384; rs12459298; rs10421235; rs1804752; rs7507757; rs1804751; rs8110602; rs1056763; rs1056765; rs41547915; rs35057974; rs41554212; rs5826705; rs10407135; rs3786999; rs746116; rs41541615; rs41563114; rs10411491; rs34718478; rs7252196; rs41547917; rs41554313; rs41549114; rs41546612; rs9973296; rs41544913; rs34660114; rs28483696; rs35663761; rs34170230; rs746117; rs8111652; rs8100041; rs10402078; rs41560514; rs35674455; rs35768770; rs5826704; rs41546216; rs41542614; rs41544516; rs8102843; rs11451497; rs35561047; rs41563416; rs12973861; rs41562619; rs41560618; rs34236901; rs10153476; rs41558812; rs10420056; rs28564211; rs35443008; rs10402097; rs10409340; rs41563414; rs41554514; rs41560520; rs41550318; rs41557116; rs3787001; rs41542013; rs7408476; rs41540412; rs41563535; rs35414347; rs9653135; rs1054794; rs10853988; rs11085144; rs11572860; rs11669519; rs11878713; rs12459773; rs12974196; rs12980310; rs2072122; rs34167478; rs35554577; rs3752158; rs3752159; rs3787002; rs3814889; rs3814890; rs3814892; rs3814893; rs3829666; rs3829958; rs4398207; rs4411625; rs4517908; rs4558525; rs4919872; rs7246140; rs7252916; rs7260011

# Metabolic_Enzyme_17_General_References:
9097968

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5344

# Metabolic_Enzyme_18_Name:
Nucleoside diphosphate kinase B

# Metabolic_Enzyme_18_Synonyms:
NDK B; NDP kinase B; nm23-H2; C-myc purine-binding transcription factor PUF

# Metabolic_Enzyme_18_Gene_Name:
NME2

# Metabolic_Enzyme_18_Protein_Sequence:
>Nucleoside diphosphate kinase 
BMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRP
FFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHG
SDSVKSAEKEISLWFKPEELVDYKSCAHDWVYE

# Metabolic_Enzyme_18_Number_of_Residues:
152

# Metabolic_Enzyme_18_Molecular_Weight:
17298

# Metabolic_Enzyme_18_Theoretical_pI:
8.69

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  nucleoside diphosphate kinase activity
 ||
>>>
Process:  CTP biosynthesis
Process:  nucleoside triphosphate metabolism
Process:  nucleoside triphosphate biosynthesis
Process:  ribonucleoside triphosphate biosynthesis
Process:  pyrimidine ribonucleoside triphosphate biosynthesis
Process:  UTP biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside triphosphate biosynthesis
Process:  purine ribonucleoside triphosphate biosynthesis
Process:  GTP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_18_Specific_Function:
Acts as a transcriptional activator of the c-Myc gene; binds DNA nonspecifically (Ref.3)

# Metabolic_Enzyme_18_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_18_Reaction:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF00334:NDK

# Metabolic_Enzyme_18_Signals:
None

# Metabolic_Enzyme_18_Transmembrane_Regions:
None

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 2.7.4.6

# Metabolic_Enzyme_18_GenBank_ID_Protein:
4467843

# Metabolic_Enzyme_18_SwissProt_ID:
NDKB_HUMAN (P22392)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
NME2

# Metabolic_Enzyme_18_Geneatlas_id:
NME2

# Metabolic_Enzyme_18_hgnc_id:
HGNC:7850

# Metabolic_Enzyme_18_PDB_ID:
1NSK

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Cytoplasm. Nucleus

# Metabolic_Enzyme_18_Gene_Sequence:
>459 bp
ATGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTG
GTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTC
CTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTACATTGACCTGAAAGACCGACCATTC
TTCCCTGGGCTGGTGAAGTACATGAACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGG
CTGAACGTGGTGAAGACAGGCCGAGTGATGCTTGGGGAGACCAATCCAGCAGATTCAAAG
CCAGGCACCATTCGTGGGGACTTCTGCATTCAGGTTGGCAGGAACATCATTCATGGCAGT
GATTCAGTAAAAAGTGCTGAAAAAGAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTT
GACTACAAGTCTTGTGCTCATGACTGGGTCTATGAATAA

# Metabolic_Enzyme_18_GenBank_ID_Gene:
X58965

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_18_Locus:
17q21.3

# Metabolic_Enzyme_18_SNPs:
Not Available

# Metabolic_Enzyme_18_General_References:
1851158; 1988104; 8392752; 7658474; 8747457

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
6018

# Metabolic_Enzyme_19_Name:
DNA-directed RNA polymerase I 135 kDa polypeptide

# Metabolic_Enzyme_19_Synonyms:
RNA polymerase I subunit 2; RPA135

# Metabolic_Enzyme_19_Gene_Name:
POLR1B

# Metabolic_Enzyme_19_Protein_Sequence:
>DNAdirected RNA polymerase I 135 kDa polypeptide
MDPGSRWRNLPSGPSLKHLTDPSYGIPREQQKAALQELTRAHVESFNYAVHEGLGLAVQA
IPPFEFAFKDERISFTILDAVISPPTVPKGTICKEANVYPAECRGRRSTYRGKLTADINW
AVNGISKGIIKQFLGYVPIMVKSKLCNLRNLPPQALIEHHEEAEEMGGYFIINGIEKVIR
MLIMPRRNFPIAMIRPKWKTRGPGYTQYGVSMHCVREEHSAVNMNLHYLENGTVMLNFIY
RKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDSFLRNSVSQMLRIVMEEGCSTQKQV
LNYLGECFRVKLNVPDWYPNEQAAEFLFNQCICIHLKSNTEKFYMLCLMTRKLFALAKGE
CMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGWLVSIKIAFDKKAQKTSVSMNTDNLMRIF
TMGIDLTKPFEYLFATGNLRSKTGLGLLQDSGLCVVADKLNFIRYLSHFRCVHRGADFAK
MRTTTVRRLLPESWGFLCPVHTPDGEPCGLMNHLTAVCEVVTQFVYTASIPALLCNLGVT
PIDGAPHRSYSECYPVLLDGVMVGWVDKDLAPGIADSLRHFKVLREKRIPPWMEVVLIPM
TGKPSLYPGLFLFTTPCRLVRPVQNLALGKEELIGTMEQIFMNVAIFEDEVFAGVTTHQE
LFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYRLQTPQSP
LVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFID
LSEKIKQGDSSLVFGIKPGDPRVLQKLDDDGLPFIGAKLQYGDPYYSYLNLNTGESFVMY
YKSKENCVVDNIKVCSNDTGSGKFKCVCITMRVPRNPTIGDKFASRHGQKGILSRLWPAE
DMPFTESGMVPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSEENSALE
YFGEMLKAAGYNFYGTERLYSGISGLELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDR
VTNQPIGGRNVQGGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSVAHVCVKCGSLLSPL
LEKPPPSWSAMRNRKYNCTLCSRSDTIDTVSVPYVFRYFVAELAAMNIKVKLDVV

# Metabolic_Enzyme_19_Number_of_Residues:
1135

# Metabolic_Enzyme_19_Molecular_Weight:
128231

# Metabolic_Enzyme_19_Theoretical_pI:
7.88

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Metabolic_Enzyme_19_General_Function:
Transcription 

# Metabolic_Enzyme_19_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. RNA polymerase I is essentially used to transcribe ribosomal DNA units

# Metabolic_Enzyme_19_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_19_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF06883:RNA_pol_Rpa2_4;
PF04563:RNA_pol_Rpb2_1;
PF04561:RNA_pol_Rpb2_2;
PF04565:RNA_pol_Rpb2_3;
PF04567:RNA_pol_Rpb2_5;
PF00562:RNA_pol_Rpb2_6;
PF04560:RNA_pol_Rpb2_7

# Metabolic_Enzyme_19_Signals:
None

# Metabolic_Enzyme_19_Transmembrane_Regions:
None

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_19_GenBank_ID_Protein:
10433976

# Metabolic_Enzyme_19_SwissProt_ID:
RPA2_HUMAN (Q9H9Y6)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
POLR1B

# Metabolic_Enzyme_19_Geneatlas_id:
POLR1B

# Metabolic_Enzyme_19_hgnc_id:
HGNC:20454

# Metabolic_Enzyme_19_PDB_ID:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_19_Gene_Sequence:
>3240 bp
ATGGATCCTGGCAGCCGGTGGCGGAACCTGCCCAGCGGGCCTAGCCTAAAGCACTTGACT
GACCCCTCTTATGGAATCCCGCGGGAACAGCAAAAGGCAGCGTTGCAGGAGCTGACGCGG
GCGCACGTGGAGTCCTTCAACTACGCTGTGCACGAGGGTCTCGGCCTCGCGGTGCAGGCT
GATATCAACTGGGCAGTGAATGGAATCTCAAAAGGAATCATTAAGCAGTTTCTTGGCTAC
GTTCCCATCATGGTGAAATCCAAGCTTTGCAACTTACGTAACCTTCCCCCACAAGCCCTC
ATTGAGCACCATGAGGAGGCAGAGGAAATGGGGGGCTATTTTATAATCAATGGCATTGAA
AAAGTCATCCGAATGTTGATTATGCCTCGGAGAAATTTTCCCATTGCAATGATAAGACCA
AAATGGAAAACCAGAGGGCCTGGTTATACTCAGTATGGAGTTTCAATGCACTGTGTGAGG
GAAGAACATTCCGCTGTCAATATGAACCTCCACTACTTGGAAAATGGCACAGTTATGTTG
AACTTTATTTACCGAAAAGAACTGTTCTTTCGTCCTTTGGGATTTGCACTTAAGGCACTT
GTCAGCTTTTCTGATTATCAGATCTTTCAGGAGCTCATCAAAGGAAAAGAGGATGATTCT
TTCCTTAGGAACTCTGTTTCTCAGATGTTAAGGATTGTAATGGAAGAGGGTTGTTTGACA
CAAAAACAGGTCCTTAACTACCTAGGTGAATGCTTCAGAGTAAAACTCAATGTTCCTGAC
TGGTACCCAAATGAGCAAGCTGCGGAGTTCCTGTTTAACCAGTGCATCTGTATCCACTTG
AAATCCAATACTGAAAAGTTTTATATGCTTTGTCTCATGACGCGAAAGCTCTTTGCTTTA
GCCAAAGGAGAGTGCATGGAGGACAATCCTGATAGTTTGGTGAACCAGGAAGTCCTCACA
CCGGGTCAGCTCTTCCTTATGTTCCTGAAGGAAAAACTGGAAGGTTGGTTAGTGTCTATT
AAAATAGCTTTTGATAAGAAGGCTCAGAAGACCAGTGTTTCCATGAACACTGACAATTTG
ATGAGGATTTTTACAATGGGCATAGACCTTACAAAACCATTTGAATACCTTTTTGCTACT
GGGAATCTGCGTTCTAAAACAGGTCTTGGCCTCCTACAAGATTCTGGACTTTGTGTTGTG
GCTGACAAGCTGAACTTCATACGCTACCTCTCCCATTTCCGCTGCGTGCACAGAGGGGCT
GATTTTGCCAAGATGAGGACCACCACAGTACGCAGGCTGCTGCCAGAGTCCTGGGGCTTC
CTTTGTCCCGTGCATACCCCAGACGGGGAGCCCTGTGGCCTGATGAACCACCTAACTGCC
GTATGTGAGGTTGTCACACAGTTTGTGTATACGGCATCTATTCCAGCTTTACTGTGCAAC
TTGGGGGTCACTCCCATTGATGGAGCTCCCCACCGATCATACAGTGAGTGCTACCCTGTC
CTGCTGGACGGTGTCATGGTTGGCTGGGTGGATAAGGATCTTGCTCCAGGCATCGCAGAT
TCTCTTCGTCATTTTAAGGTGTTGAGAGAGAAAAGAATTCCTCCCTGGATGGAAGTGGTC
CTTATACCCATGACAGGAAAACCAAGTCTGTACCCAGGATTGTTCCTTTTTACCACTCCT
TGTAGACTGGTACGGCCTGTGCAGAACTTAGCATTGGGCAAAGAAGAGCTAATTGGAACT
ATGGAACAGATCTTCATGAATGTCGCTATCTTTGAGGATGAAGTTTTTGCTGGAGTTACC
ACACACCAGGAACTCTTTCCACACAGCCTGCTGAGTGTGATTGCCAACTTCATCCCTTTC
TCTGATCACAACCAGAGTCCACGGAACATGTACCAATGCCAGATGGGTAAGCAAACTATG
GGCTTTCCACTTCTCACTTATCAAGACCGATCGGATAACAAACTGTATCGTCTTCAGACT
CCTCAGAGTCCCTTGGTGAGACCCTCCATGTATGATTATTATGACATGGATAACTATCCA
ATTGGGACCAATGCCATCGTTGCTGTGATTTCTTACACTGGCTATGATATGGAAGATGCC
ATGATTGTGAATAAGGCCTCTTGGGAACGAGGCTTTGCCCATGGAAGTGTCTACAAGTCT
GAGTTCATAGACCTCTCTGAAAAAATTAAACAAGGAGATAGTAGCCTGGTGTTTGGCATC
AAACCTGGTGACCCACGCGTTCTGCAGAAGTTAGATGACGATGGATTGCCGTTTATAGGA
GCAAAACTGCAGTACGGAGATCCGTATTACAGCTACCTCAACCTCAACACCGGGGAAAGT
TTTGTGATGTACTATAAGAGTAAAGAAAATTGTGTTGTGGATAACATCAAAGTGTGCAGT
AATGACACTGGGAGTGGAAAATTCAAGTGTGTTCGCATCACTATGAGAGTGCCTCGGAAC
CCAACTATCGGAGATAAATTTGCCAGTCGCCATGGGCGGAAGGGCATTTTAAGCAGATTG
TGGCCGGCTGAGGACATGCCTTTTACTGAGAGTGGGATGGTCCCAGACATTCTGTTCAAT
CCCCATGGTTTTCCATCCCGCATGACCATTGGGATGTTAATTGAGAGTATGGCCGGGAAG
TCTGCAGCTTTGCATGGTCTCTGCCATGATGCTACACCCTTCATCTTCTCAGAGGAGAAC
TCGGCCTTAGAATACTTTGGTGAGATGTTAAAGGCTGCTGGCTACAATTTCTATGGCACC
GAGAGGTTATATAGTGGCATCAGTGGGCTAGAACTGGAAGCAGACATCTTCATAGGAGTG
GTTTATTATCAGCGCTTACGCCATATGGTCTCAGACAAATTTCAAGTAAGGACAACTGGA
GCCCGAGACAGAGTCACCAACCAGCCTATTGGGGGAAGAAATGTCCAGGGTGGAATCCGT
TTTGGGGAGATGGAACGGGATGCGCTTTTAGCTCATGGTACATCTTTTCTCCTTCATGAC
CGCCTCTTCAACTGCTCAGATCGGTCGGTAGCCCATGTGTGTGTGAAGTGTGGCAGTTTA
CTCTCTCCACTGTTGGAGAAGCCACCCCCTTCTTGGTCTGCCATGCGCAACAGAAAATAC
AACTGTACTCTGTGTAGTCGCAGTGACACTATCGATACTGTTTCTGTGCCTTATGTTTTT
CGGTATTTTGTAGCTGAACTGGCAGCTATGAACATCAAAGTGAAACTGGATGTTGTTTAA


# Metabolic_Enzyme_19_GenBank_ID_Gene:
AK022533

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_19_Locus:
2q13

# Metabolic_Enzyme_19_SNPs:
rs1545133; rs6719657; rs2304555; rs34754362; rs34051897; rs34628059; rs10205187; rs10496441; rs7578724; rs17586430; rs3961914; rs6707131; rs6760906; rs10864905; rs7586668; rs3789724; rs13010814; rs6746874; rs11677050; rs3816141; rs10169344; rs1437673; rs4849072; rs6756251; rs4849075; rs6734172; rs10197847; rs9308672; rs10183849; rs11676962; rs4849073; rs4849071; rs7568539; rs13395779; rs6712366; rs6542062; rs11123140; rs3816140; rs12618882; rs9308673; rs3980079; rs2241804; rs10169290; rs3980078; rs3789723; rs4849074; rs13416022; rs7598338; rs7607358; rs6715645; rs3961775; rs11123139; rs10864904; rs11123141; rs1595388; rs1437675; rs13424021; rs13395691; rs35318690; rs34159868; rs35001671; rs12995202; rs11298106; rs2716669; rs1111526; rs34875913; rs11902123; rs35786464; rs3860388; rs34076573; rs13015669; rs4849076; rs13002935; rs35101761; rs35694666; rs36076008; rs12989687; rs35806719; rs6715788; rs13010601; rs34779128; rs34864218; rs36057006; rs11360715; rs9808491; rs11883446; rs11689338; rs35459414; rs6743755; rs34137042; rs13409416; rs13413001; rs35787315; rs10709747; rs13400895; rs10566214; rs34474551; rs7597698; rs35164717; rs11313474; rs13412193; rs34282578; rs34591927; rs10703950; rs11675730; rs35724716; rs11362371; rs13015600; rs41280572; rs3980077; rs34385497; rs7575033; rs13004248; rs13018087; rs10713970; rs11335756; rs7570791; rs11351307; rs34117931; rs35338335; rs13015822; rs13030036; rs13033112; rs41278940; rs34661360; rs13391167; rs13424402; rs34006251; rs12464781; rs35176893; rs13382680; rs34216136; rs35048198; rs10153801; rs13389720; rs1583616; rs3748026; rs3961916; rs4365467; rs719667; rs719668; rs7506; rs768069

# Metabolic_Enzyme_19_General_References:
Not Available

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
6019

# Metabolic_Enzyme_20_Name:
DNA-directed RNA polymerase III subunit G

# Metabolic_Enzyme_20_Synonyms:
DNA-directed RNA polymerase III 32 kDa polypeptide; RNA polymerase III C32 subunit

# Metabolic_Enzyme_20_Gene_Name:
POLR3G

# Metabolic_Enzyme_20_Protein_Sequence:
>DNAdirected RNA polymerase III subunit 
GMAGNKGRGRAAYTFNIEAVGFSKGEKLPDVVLKPPPLFPDTDYKPVPLKTGEGEEYMLA
LKQELRETMKRMPYFIETPEERQDIERYSKRYMKVYQEEWIPDWRRLPREMMPRNKCKKA
GPKPKKAKDAGKGTPLTNTEDVLKKMVELEKRGDGEKSDEENEEKEGSKEKSKEGDDDDD
DDAAEQEEYDEEEQEEENDYINSYFEDGDDFGADVMTTWMRQPIRHEIFQKIFL

# Metabolic_Enzyme_20_Number_of_Residues:
233

# Metabolic_Enzyme_20_Molecular_Weight:
27300

# Metabolic_Enzyme_20_Theoretical_pI:
4.45

# Metabolic_Enzyme_20_GO_Classification:
Not Available

# Metabolic_Enzyme_20_General_Function:
Not Available

# Metabolic_Enzyme_20_Specific_Function:
May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation

# Metabolic_Enzyme_20_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_20_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_20_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_20_Signals:
None

# Metabolic_Enzyme_20_Transmembrane_Regions:
None

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_20_GenBank_ID_Protein:
2228750

# Metabolic_Enzyme_20_SwissProt_ID:
RPO3G_HUMAN (O15318)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
POLR3G

# Metabolic_Enzyme_20_Geneatlas_id:
POLR3G

# Metabolic_Enzyme_20_hgnc_id:
HGNC:30075

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Nucleus (Potential)

# Metabolic_Enzyme_20_Gene_Sequence:
>702 bp
ATGGCTGGGAATAAAGGAAGAGGACGTGCTGCTTATACCTTTAATATTGAGGCTGTTGGA
TTTAGCAAAGGTGAAAAGTTACCTGATGTAGTGTTGAAACCACCCCCACTATTTCCTGAT
ACAGATTATAAACCAGTACCACTGAAAACAGGAGAAGGTGAAGAATATATGCTGGCTTTG
AAACAGGAGTTGAGAGAAACAATGAAAAGAATGCCTTATTTTATTGAAACACCTGAAGAA
AGACAAGATATTGAAAGGTATAGTAAAAGATACATGAAGGTATACCAGGAAGAATGGATA
CCAGATTGGAGAAGACTTCCAAGAGAGATGATGCCAAGAAATAAATGTAAAAAAGCAGGC
CCAAAACCCAAAAAGGCAAAAGACGCAGGCAAAGGCACACCACTCACTAATACTGAAGAT
GTGTTGAAAAAAATGGTGGAATTGGAAAAAAGAGGTGATGGTGAAAAATCAGATGAGGAA
AATGAAGAGAAAGAAGGAAGCAAAGAGAAAAGTAAAGAAGGTGATGATGACGATGACGAT
GATGCCGCAGAACAGGAGGAATATGATGAAGAAGAGCAAGAAGAGGAAAATGACTACATT
AATTCATACTTTGAAGATGGAGATGATTTTGGCGCAGACGTGATGACAACATGGATGAGG
CAACCTATTAGGCATGAAATTTTTCAAAAAATATTTTTATGA

# Metabolic_Enzyme_20_GenBank_ID_Gene:
U93868

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_20_Locus:
5q14.3

# Metabolic_Enzyme_20_SNPs:
rs7712322; rs6894539; rs2562520; rs2562519; rs11750517; rs10942595; rs3933063; rs1544958; rs2938788; rs2914672; rs2562518; rs13181086; rs17539414; rs2963698; rs250375; rs2255938; rs2115500; rs1508788; rs2366768; rs3805480; rs2656953; rs10462342; rs27658; rs2562515; rs6452887; rs4569906; rs6897490; rs27198; rs6897910; rs10514327; rs27200; rs7725495; rs3805483; rs40204; rs10942596; rs7726781; rs12655180; rs10942597; rs6877613; rs11743030; rs27963; rs250376; rs6896937; rs2562517; rs185143; rs812594; rs13189520; rs3805481; rs250374; rs10074717; rs250373; rs34272172; rs35917267; rs809840; rs790080; rs13190292; rs35269932; rs10652126; rs10717708; rs3842598; rs35557396; rs34379506; rs12374570; rs11336567; rs34811985; rs34509305; rs35984416; rs16868693; rs10614541; rs35140099; rs11331138; rs10686849; rs5869507; rs2656952; rs34046633; rs10064797; rs13183906; rs16868744; rs6877680; rs790082; rs13178317; rs35355429; rs12522078; rs35500970; rs35407205; rs34480064; rs12522061; rs35627067; rs13187919; rs36102068; rs250372; rs13166243; rs7712128; rs34374200; rs11364397; rs11954013; rs3840321; rs4355553; rs2656951; rs35908709; rs1234862; rs36062804; rs34269061; rs13184285; rs35534076; rs35513125; rs13157684; rs13178737; rs34685868; rs11340730; rs10675068; rs12652604; rs2562516; rs13175236; rs6877977; rs11340729; rs13166259; rs35692945; rs7724507; rs34906852; rs10474326; rs11743044; rs11749808; rs11954669; rs12109087; rs12519671; rs13169686; rs13356310; rs16868673; rs16868767; rs2115501; rs2162986; rs2303801; rs27601; rs2914673; rs2914674; rs3087840; rs3172792; rs3172793; rs35599358; rs37480; rs3763070; rs3763072; rs3805478; rs6862171; rs9293544

# Metabolic_Enzyme_20_General_References:
9171375

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
6020

# Metabolic_Enzyme_21_Name:
DNA-directed RNA polymerase II subunit I

# Metabolic_Enzyme_21_Synonyms:
DNA-directed RNA polymerase II 14.5 kDa polypeptide; RPB9; RPB14.5

# Metabolic_Enzyme_21_Gene_Name:
POLR2I

# Metabolic_Enzyme_21_Protein_Sequence:
>DNAdirected RNA polymerase II subunit 
IMEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKIT
HEVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHC
GHRWTE

# Metabolic_Enzyme_21_Number_of_Residues:
125

# Metabolic_Enzyme_21_Molecular_Weight:
14523

# Metabolic_Enzyme_21_Theoretical_pI:
4.79

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  transcription factor activity
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
Process:  transcription, DNA-dependent
Process:  RNA elongation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Transcription 

# Metabolic_Enzyme_21_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

# Metabolic_Enzyme_21_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_21_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF02150:RNA_POL_M_15KD

# Metabolic_Enzyme_21_Signals:
None

# Metabolic_Enzyme_21_Transmembrane_Regions:
None

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_21_GenBank_ID_Protein:
397150

# Metabolic_Enzyme_21_SwissProt_ID:
RPB9_HUMAN (P36954)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
POLR2I

# Metabolic_Enzyme_21_Geneatlas_id:
POLR2I

# Metabolic_Enzyme_21_hgnc_id:
HGNC:9196

# Metabolic_Enzyme_21_PDB_ID:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_21_Gene_Sequence:
>378 bp
ATGGAGCCCGACGGGACTTACGAGCCGGGCTTCGTGGGTATTCGCTTCTGCCAGGAATGT
AACAACATGCTGTACCCCAAGGAAGACAAGGAGAACCGCATTCTGCTCTACGCGTGCCGG
AACTGTGATTACCAGCAGGAGGCCGACAACAGCTGCATCTATGTCAACAAGATCACGCAC
GAAGTGGACGAACTGACCCAGATTATCGCCGACGTGTCCCAGGACCCCACGTTGCCGCGG
ACCGAGGACCACCCGTGCCAAAAGTGCGGCCACAAGGAGGCTGTGTTCTTCCAGTCACAC
AGTGCGCGGGCCGAGGACGCCATGCGCCTTTACTACGTGTGCACAGCCCCACACTGCGGC
CACCGCTGGACCGAGTGA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
Z23102

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_21_Locus:
19q12

# Metabolic_Enzyme_21_SNPs:
Not Available

# Metabolic_Enzyme_21_General_References:
8265347

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
6021

# Metabolic_Enzyme_22_Name:
Phosphatidate cytidylyltransferase 2

# Metabolic_Enzyme_22_Synonyms:
CDP-diglyceride synthetase 2; CDP-diglyceride pyrophosphorylase 2; CDP- diacylglycerol synthase 2; CDS 2; CTP:phosphatidate cytidylyltransferase 2; CDP-DAG synthase 2; CDP-DG synthetase 2

# Metabolic_Enzyme_22_Gene_Name:
CDS2

# Metabolic_Enzyme_22_Protein_Sequence:
>Phosphatidate cytidylyltransferase 2
MTELRQRVAHEPVAPPEDKESESEAKVDGETASDSESRAESAPLPVSADDTPEVLNRALS
NLSSRWKNWWVRGILTLAMIAFFFIIIYLGPMVLMIIVMCVQIKCFHEIITIGYNVYHSY
DLPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQREEPLRILSKYHRFISFTLYLIGFCM
FVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLVIHNLFEGMIWFIVPISCVICNDIMAY
MFGFFFGRTPLIKLSPKKTWEGFIGGFFATVVFGLLLSYVMSGYRCFVCPVEYNNDTNSF
TVDCEPSDLFRLQEYNIPGVIQSVIGWKTVRMYPFQIHSIALSTFASLIGPFGGFFASGF
KRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVNVYIASFIRGPNPSKLIQQFLTLRPDQ
QLHIFNTLRSHLIDKGMLTSTTEDE

# Metabolic_Enzyme_22_Number_of_Residues:
445

# Metabolic_Enzyme_22_Molecular_Weight:
51419

# Metabolic_Enzyme_22_Theoretical_pI:
7.10

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  phosphatidate cytidylyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  phospholipid metabolism
Process:  phospholipid biosynthesis
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_22_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_22_Specific_Function:
Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin

# Metabolic_Enzyme_22_Pathway:
map00564  Glycerophospholipid metabolism;
 map04070  Phosphatidylinositol signaling system

# Metabolic_Enzyme_22_Reaction:
CTP + phosphatidate = diphosphate + CDP-diacylglycerol

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF01148:CTP_transf_1

# Metabolic_Enzyme_22_Signals:
None

# Metabolic_Enzyme_22_Transmembrane_Regions:
79-99
132-152
166-186
213-233
262-282
340-360

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 2.7.7.41

# Metabolic_Enzyme_22_GenBank_ID_Protein:
4186023

# Metabolic_Enzyme_22_SwissProt_ID:
CDS2_HUMAN (O95674)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
CDS2

# Metabolic_Enzyme_22_Geneatlas_id:
CDS2

# Metabolic_Enzyme_22_hgnc_id:
HGNC:1801

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane; multi-pass membrane protein; matrix side (Potential)

# Metabolic_Enzyme_22_Gene_Sequence:
>1338 bp
ATGACAGAGCTGAGGCAGAGGGTGGCCCATGAGCCGGTTGCGCCACCCGAGGACAAGGAG
TCAGAGTCAGAAGCAAAGGTAGATGGAGAGACTGCATCGGACAGTGAGAGCCGGGCAGAA
TCCGCACCCCTGCCAGTCTCTGCAGATGATACCCCGGAGGTCCTCAATAGGGCCCTTTCC
AACTTGTCTTCAAGATGGAAGAACTGGTGGGTGAGAGGCATCCTGACTTTGGCCATGATT
GCATTTTTCTTCATCATCATTTACCTGGGACCAATGGTTTTGATGATAATCGTGATGTGC
GTTCAGATTAAGTGTTTCCATGAGATAATCACTATTGGCTACAACGTCTACCACTCATAT
GATCTGCCCTGGTTCAGGACGCTCAGCTGGTACTTTCTCCTGTGTGTAAACTATTTCTTC
TATGGTGAGACAGTGACGGATTACTTCTTCACCCTGGTCCAGAGAGAAGAGCCTTTGCGG
ATTCTCAGTAAATACCACCGGTTCATTTCCTTTACTCTCTATCTAATAGGATTCTGCATG
TTTGTACTGAGTCTGGTCAAGAAGCATTATCGACTGCAGTTCTACATGTTTGGCTGGACC
CATGTGACATTGCTGATTGTTGTAACACAGTCACATCTTGTTATCCACAACCTATTTGAA
GGAATGATCTGGTTCATTGTCCCCATATCTTGTGTGATCTGTAATGACATCATGGCCTAT
ATGTTTGGCTTTTTCTTTGGTCGGACCCCACTCATCAAGCTGTCCCCGAAGAAGACCTGG
GAAGGCTTCATTGGGGGCTTCTTTGCTACTGTGGTGTTTGGCCTTCTGCTGTCCTATGTG
ATGTCCGGGTACAGATGCTTTGTCTGCCCTGTGGAGTACAACAATGACACCAACAGCTTC
ACTGTGGACTGTGAGCCCTCGGACCTGTTTCGCCTGCAGGAGTACAACATTCCTGGGGTG
ATCCAGTCAGTCATTGGCTGGAAAACGGTCCGGATGTACCCCTTCCAGATTCACAGCATC
GCTCTCTCCACCTTTGCCTCGCTCATTGGCCCCTTTGGAGGATTCTTCGCAAGTGGATTC
AAACGAGCCTTTAAAATCAAAGACTTTGCCAATACCATTCCTGGCCATGGAGGCATCATG
GATCGCTTTGACTGCCAGTATCTGATGGCCACCTTTGTCAATGTATACATCGCCAGTTTT
ATCAGAGGCCCTAACCCAAGCAAACTGATTCAGCAGTTCCTGACTTTACGGCCAGATCAG
CAGCTCCACATCTTCAACACGCTGCGGTCTCATCTGATCGACAAAGGGATGCTGACATCC
ACCACAGAGGACGAGTAG

# Metabolic_Enzyme_22_GenBank_ID_Gene:
Y16521

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_22_Locus:
20p13

# Metabolic_Enzyme_22_SNPs:
rs3818196; rs34096549; rs35796695; rs3746676; rs16990718; rs1470351; rs2295509; rs1292197; rs2281557; rs2295507; rs6053181; rs6053159; rs6038080; rs6053149; rs6053160; rs7266351; rs6076781; rs6038077; rs2295508; rs7271989; rs4815765; rs6107589; rs12625930; rs1470352; rs6085020; rs11904988; rs6053173; rs4815768; rs4239762; rs6085011; rs6085019; rs6053147; rs6053162; rs4815767; rs6053166; rs6053183; rs1040759; rs6076783; rs6053165; rs16990713; rs6085014; rs6116658; rs6085010; rs6038084; rs7264821; rs6053177; rs6116661; rs6053128; rs16990712; rs11699315; rs6107582; rs6116678; rs6053158; rs6139641; rs10485482; rs6038087; rs4239761; rs6107580; rs6053152; rs7268859; rs10485483; rs6107584; rs7266704; rs6116673; rs6053127; rs6053167; rs7272236; rs11699947; rs6053163; rs6076782; rs12625556; rs1040758; rs1040757; rs17178968; rs11700061; rs6053178; rs11699197; rs6053142; rs6038078; rs6038085; rs6053129; rs7263689; rs16990677; rs2423089; rs261345; rs7266338; rs6116670; rs7267572; rs6053138; rs17178947; rs6116667; rs6107581; rs6053155; rs6076786; rs11700251; rs7267961; rs11698565; rs11699184; rs9973978; rs6038073; rs17720457; rs1985928; rs6116671; rs7273726; rs11697819; rs6038083; rs11700072; rs6053182; rs6038074; rs6053168; rs17178828; rs16990673; rs1292198; rs6053154; rs16990670; rs6076785; rs6053130; rs6139640; rs11696229; rs6053135; rs7267176; rs7264168; rs11697688; rs6116663; rs6139635; rs6085018; rs6053187; rs6053186; rs6116672; rs11907537; rs11698682; rs261343; rs11698683; rs2083918; rs7271748; rs17178759; rs6085017; rs17776782; rs13043769; rs12151928; rs6038079; rs16990681; rs17785258; rs6053137; rs6053180; rs6053150; rs16990695; rs3746677; rs16990725; rs35315800; rs5013472; rs6116682; rs11477708; rs41282114; rs6053184; rs6116675; rs6053140; rs35156274; rs6139637; rs35573375; rs7363513; rs11476644; rs17785222; rs6107587; rs35415513; rs6085022; rs13043479; rs6053139; rs6053133; rs8119511; rs13043295; rs6076784; rs6107591; rs6139643; rs6116681; rs6085013; rs11483758; rs12233280; rs6085016; rs6053185; rs6133191; rs11481738; rs34764405; rs35229848; rs13045245; rs6139633; rs7264879; rs8116946; rs6116659; rs11287231; rs6107586; rs7271361; rs6053176; rs1292243; rs35060749; rs3056125; rs6116665; rs6076779; rs6139638; rs34865021; rs13040625; rs34117826; rs35882441; rs13040144; rs6133192; rs1299877; rs261344; rs6053134; rs9753596; rs7263872; rs4815769; rs36076691; rs41282118; rs6139645; rs35752638; rs8119283; rs6116674; rs6116669; rs34394718; rs6116664; rs6139644; rs7264643; rs6085012; rs6053164; rs13043341; rs36045372; rs6116677; rs11475285; rs35597371; rs6139634; rs6053175; rs6053144; rs6085015; rs6085023; rs10558875; rs6139642; rs34696412; rs11472526; rs11297837; rs6053145; rs11470766; rs2083919; rs11315375; rs13043165; rs11379853; rs6139639; rs41282116; rs41309923; rs11479423; rs6053157; rs34544851; rs35581854; rs13040042; rs7271364; rs6038075; rs36126594; rs6038081; rs6053131; rs6085024; rs34669772; rs6053153; rs6053151; rs7361389; rs13040145; rs9753591; rs6139646; rs11470811; rs6116660; rs3056122; rs28768676; rs6053179; rs34586494; rs13043342; rs6053136; rs34862422; rs6133190; rs12624410; rs13040138; rs6116676; rs28813461; rs6053146; rs11482992; rs11697399; rs9753717; rs35331752; rs34044855; rs1292196; rs35126126; rs6053174; rs8119108; rs13043892; rs11395331; rs6107588; rs35035577; rs11440121; rs6053132; rs6116679; rs6139636; rs11293483; rs6107583; rs34172087; rs6076780; rs35190424; rs6116662; rs6116668; rs6085025; rs6116684; rs35911658; rs3833325; rs6116683; rs34055146; rs1050525; rs11700149; rs12624765; rs1292244; rs17179149; rs17349; rs17351; rs17352; rs17785402; rs2295510; rs2295511; rs25406; rs3730416; rs3730423; rs3730424; rs3730425; rs3730426; rs3730427; rs3730428; rs3746678; rs3746679; rs4815770; rs6038088; rs6053188; rs6053189; rs6053190; rs6085026; rs6107578; rs6107592; rs6116685; rs6116686; rs6139626; rs732817; rs8122586; rs8125170; rs8184346

# Metabolic_Enzyme_22_General_References:
9889000; 11780052; 9806839

# Metabolic_Enzyme_22_References:
Not Available

# Metabolic_Enzyme_23_ID:
6022

# Metabolic_Enzyme_23_Name:
DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide

# Metabolic_Enzyme_23_Synonyms:
RPB17; RPB8; RPABC3

# Metabolic_Enzyme_23_Gene_Name:
POLR2H

# Metabolic_Enzyme_23_Protein_Sequence:
>DNAdirected RNA polymerases I, II, and III 17.1 kDa polypeptide
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

# Metabolic_Enzyme_23_Number_of_Residues:
150

# Metabolic_Enzyme_23_Molecular_Weight:
17143

# Metabolic_Enzyme_23_Theoretical_pI:
4.27

# Metabolic_Enzyme_23_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_23_General_Function:
Not Available

# Metabolic_Enzyme_23_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

# Metabolic_Enzyme_23_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_23_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF03870:RNA_pol_Rpb8

# Metabolic_Enzyme_23_Signals:
None

# Metabolic_Enzyme_23_Transmembrane_Regions:
None

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_23_GenBank_ID_Protein:
1017823

# Metabolic_Enzyme_23_SwissProt_ID:
RPB8_HUMAN (P52434)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
POLR2H

# Metabolic_Enzyme_23_Geneatlas_id:
POLR2H

# Metabolic_Enzyme_23_hgnc_id:
HGNC:9195

# Metabolic_Enzyme_23_PDB_ID:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Nucleus; nucleolus

# Metabolic_Enzyme_23_Gene_Sequence:
>453 bp
ATGGCGGGCATCCTGTTTGAGGATATTTTCGATGTGAAGGATATTGACCCGGAGGCCAAG
AAGTTTGACCGAGTGTCTCGACTGCATTGTGAGAGTGAATCTTTCAAGATGGATCTAATC
TTAGATGTAAACATTCAAATTTACCCTGTAGACTTGGGTGACAAGTTTCGGTTGGTCATA
GCTAGTACCTTGTATGAAGATGGTACCCTGGATGATGGTGAATACAACCCCACTGATGAT
AGGCCTTCCAGGGCTGACCAGTTTGAGTATGTAATGTATGGAAAAGTGTACAGGATTGAG
GGAGATGAAACTTCTACTGAAGCAGCAACACGCCTCTCTGCGTACGTGTCCTATGGGGGC
CTGCTCATGAGGCTGCAGGGGGATGCCAACAACCTGCATGGATTCGAGGTGGACTCCAGA
GTTTATCTCCTGATGAAGAAGCTAGCCTTCTGA

# Metabolic_Enzyme_23_GenBank_ID_Gene:
U37689

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_23_Locus:
3q28

# Metabolic_Enzyme_23_SNPs:
rs4912485; rs28467468; rs11556517; rs11556518; rs1802869; rs11556516; rs9876991; rs10577978; rs41266277; rs41553320; rs41559914; rs41560114; rs7615189; rs9839661; rs41266273; rs10575340; rs9839511; rs35073239; rs41266275; rs7652854; rs1042346; rs1042348; rs10513797; rs1126664; rs1126665; rs13084750; rs13091574; rs13094594; rs13099401; rs16858759; rs2228291; rs2280740; rs2700322; rs34658600; rs35633216; rs35794435; rs3749221; rs3749222; rs3792299; rs3804618; rs4912484; rs4912486; rs4912487; rs6141; rs6142; rs952982; rs956732

# Metabolic_Enzyme_23_General_References:
8524256; 7651387

# Metabolic_Enzyme_23_References:
Not Available

# Metabolic_Enzyme_24_ID:
6023

# Metabolic_Enzyme_24_Name:
DNA-directed RNA polymerases I, II, and III 7.0 kDa polypeptide

# Metabolic_Enzyme_24_Synonyms:
ABC10-alpha; RPB7.0; RPB10alpha; RPABC4

# Metabolic_Enzyme_24_Gene_Name:
POLR2K

# Metabolic_Enzyme_24_Protein_Sequence:
>DNAdirected RNA polymerases I, II, and III 7.0 kDa polypeptide
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

# Metabolic_Enzyme_24_Number_of_Residues:
58

# Metabolic_Enzyme_24_Molecular_Weight:
7004

# Metabolic_Enzyme_24_Theoretical_pI:
9.34

# Metabolic_Enzyme_24_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_24_General_Function:
Transcription 

# Metabolic_Enzyme_24_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

# Metabolic_Enzyme_24_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_24_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_24_Pfam_Domain_Function:
PF03604:DNA_RNApol_7kD

# Metabolic_Enzyme_24_Signals:
None

# Metabolic_Enzyme_24_Transmembrane_Regions:
None

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_24_GenBank_ID_Protein:
717187

# Metabolic_Enzyme_24_SwissProt_ID:
RPC10_HUMAN (P53803)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
POLR2K

# Metabolic_Enzyme_24_Geneatlas_id:
POLR2K

# Metabolic_Enzyme_24_hgnc_id:
HGNC:9198

# Metabolic_Enzyme_24_PDB_ID:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_24_Gene_Sequence:
>177 bp
ATGGACACCCAGAAGGACGTTCAACCTCCAAAGCAGCAACCAATGATATATATCTGTGGA
GAGTGTCACACAGAAAATGAAATAAAATCTAGGGATCCAATCAGATGCAGAGAATGTGGA
TACAGAATAATGTACAAGAAAAGGACTAAAAGATTGGTCGTTTTTGATGCTCGATGA

# Metabolic_Enzyme_24_GenBank_ID_Gene:
Z47727

# Metabolic_Enzyme_24_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_24_Locus:
8q22.2

# Metabolic_Enzyme_24_SNPs:
rs2453640; rs2254883; rs7924; rs3104196; rs3752833; rs2453641; rs2453643; rs3133677; rs2453638; rs2453639; rs3779810; rs16897989; rs34899369; rs11555067; rs14960; rs11555069; rs2453642; rs1056585; rs2935120; rs28680466; rs41548619; rs2446923; rs28545801; rs28576993; rs2935119; rs2453637; rs13248578; rs13250370; rs1460934; rs16898015; rs1993708; rs2008612; rs2279102; rs2306044; rs2453634; rs2453644; rs2453645; rs2453646; rs2514690; rs2514691; rs2514692; rs2926763; rs2980530; rs2980544; rs3019097; rs3019098; rs3104193; rs3104195; rs3104197; rs3133407; rs3133668; rs3133672; rs3133673; rs3133674; rs3133676; rs4734452

# Metabolic_Enzyme_24_General_References:
7651387

# Metabolic_Enzyme_24_References:
Not Available

# Metabolic_Enzyme_25_ID:
6024

# Metabolic_Enzyme_25_Name:
DNA-directed RNA polymerase II 16 kDa polypeptide

# Metabolic_Enzyme_25_Synonyms:
RPB4

# Metabolic_Enzyme_25_Gene_Name:
POLR2D

# Metabolic_Enzyme_25_Protein_Sequence:
>DNAdirected RNA polymerase II 16 kDa polypeptide
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY

# Metabolic_Enzyme_25_Number_of_Residues:
142

# Metabolic_Enzyme_25_Molecular_Weight:
16311

# Metabolic_Enzyme_25_Theoretical_pI:
4.46

# Metabolic_Enzyme_25_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_25_General_Function:
Not Available

# Metabolic_Enzyme_25_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Associates with POLR2G

# Metabolic_Enzyme_25_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_25_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_25_Pfam_Domain_Function:
PF03874:RNA_pol_Rpb4

# Metabolic_Enzyme_25_Signals:
None

# Metabolic_Enzyme_25_Transmembrane_Regions:
None

# Metabolic_Enzyme_25_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_25_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_25_GenBank_ID_Protein:
2253635

# Metabolic_Enzyme_25_SwissProt_ID:
RPB4_HUMAN (O15514)

# Metabolic_Enzyme_25_swissprot_Name:
Not Available

# Metabolic_Enzyme_25_Genecard_id:
POLR2D

# Metabolic_Enzyme_25_Geneatlas_id:
POLR2D

# Metabolic_Enzyme_25_hgnc_id:
HGNC:9191

# Metabolic_Enzyme_25_PDB_ID:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_25_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_25_Gene_Sequence:
>429 bp
ATGGCGGCGGGTGGCAGCGATCCGCGGGCTGGCGACGTAGAGGAGGACGCCTCACAGCTC
ATCTTTCCTAAAGAGTTTGAAACAGCTGAGACACTTCTAAATTCAGAAGTTCATATGCTT
CTGGAACATCGAAAGCAGCAGAATGAGAGTGCAGAGGACGAACAGGAGCTCTCAGAAGTC
TTCATGAAAACATTAAACTACACAGCCCGTTTCAGTCGTTTCAAAAACAGAGAGACCATT
GCCAGTGTTCGTAGCTTGCTACTCCAGAAAAAGCTTCATAAGTTTGAGTTGGCCTGTTTG
GCCAACCTTTGCCCAGAGACTGCTGAGGAGTCCAAGGCTCTAATCCCAAGCTTGGAGGGA
CGGTTTGAAGATGAGGAGCTGCAGCAGATTCTTGATGATATCCAGACAAAGCGCAGCTTT
CAGTATTAA

# Metabolic_Enzyme_25_GenBank_ID_Gene:
U89387

# Metabolic_Enzyme_25_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_25_Locus:
2q21

# Metabolic_Enzyme_25_SNPs:
rs10210695; rs13382312; rs14506; rs7605158; rs3816127; rs7604802; rs7597691; rs3771290; rs6713679; rs6734925; rs17015615; rs17340489; rs7601795; rs11691858; rs35614229; rs17015618; rs6721274; rs11889664; rs1061056; rs2948069; rs11674513; rs41542218; rs1804818; rs41547213; rs1804817; rs41552916; rs10206169; rs10171898; rs13031513; rs35664819; rs35334001; rs35261446; rs2461448; rs2576434; rs35064392; rs13005809; rs34803766; rs2576433; rs2461447; rs34586517; rs2438032; rs2856460; rs34025347; rs2859532; rs34858843; rs2856457; rs34706819; rs9630959; rs2856459; rs13013018; rs13423602; rs2576431; rs10644256; rs2461449; rs2576435; rs34249256; rs13032850; rs2856461; rs3836128; rs2856458; rs41544312; rs35053936; rs35971047; rs41557712; rs2576432; rs2438033; rs34873180; rs3205878; rs34630118; rs12900; rs12621890; rs3205880; rs11686632; rs6746537; rs35328801; rs10639803; rs3205876; rs3205879; rs10639802; rs35880261; rs34312606; rs1045832; rs10928787; rs11685164; rs11693759; rs12104767; rs13397060; rs13411546; rs1550175; rs17340503; rs17600636; rs2118203; rs2118204; rs2261682; rs2576436; rs34504853; rs3755305

# Metabolic_Enzyme_25_General_References:
9528765

# Metabolic_Enzyme_25_References:
Not Available

# Metabolic_Enzyme_26_ID:
6025

# Metabolic_Enzyme_26_Name:
DNA-directed RNA polymerase II 23 kDa polypeptide

# Metabolic_Enzyme_26_Synonyms:
RPB25; RPB5; RPABC1; XAP4

# Metabolic_Enzyme_26_Gene_Name:
POLR2E

# Metabolic_Enzyme_26_Protein_Sequence:
>DNAdirected RNA polymerase II 23 kDa polypeptide
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

# Metabolic_Enzyme_26_Number_of_Residues:
210

# Metabolic_Enzyme_26_Molecular_Weight:
24552

# Metabolic_Enzyme_26_Theoretical_pI:
5.76

# Metabolic_Enzyme_26_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_26_General_Function:
Transcription 

# Metabolic_Enzyme_26_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

# Metabolic_Enzyme_26_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_26_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_26_Pfam_Domain_Function:
PF01191:RNA_pol_Rpb5_C;
PF03871:RNA_pol_Rpb5_N

# Metabolic_Enzyme_26_Signals:
None

# Metabolic_Enzyme_26_Transmembrane_Regions:
None

# Metabolic_Enzyme_26_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_26_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_26_GenBank_ID_Protein:
678549

# Metabolic_Enzyme_26_SwissProt_ID:
RPB5_HUMAN (P19388)

# Metabolic_Enzyme_26_swissprot_Name:
Not Available

# Metabolic_Enzyme_26_Genecard_id:
POLR2E

# Metabolic_Enzyme_26_Geneatlas_id:
POLR2E

# Metabolic_Enzyme_26_hgnc_id:
HGNC:9192

# Metabolic_Enzyme_26_PDB_ID:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_26_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_26_Gene_Sequence:
>633 bp
ATGGACGACGAGGAGGAGACGTACCGGCTCTGGAAAATCCGCAAGACCATCATGCAGCTG
TGCCACGACCGTGGCTATCTGGTGACCCAGGACGAGCTTGACCAGACCCTGGAGGAGTTC
AAAGCCCAATTTGGGGACAAGCCGAGTGAGGGGCGGCCGCGGCGCACGGACCTCACCGTG
CTGGTGGCCCACAACGATGACCCCACCGACCAGATGTTTGTGTTCTTTCCAGAGGAGCCC
AAGGTGGGCATCAAGACCATCAAGGTGTACTGCCAGCGCATGCAGGAGGAGAACATCACA
CGGGCTCTCATCGTGGTGCAGCAGGGCATGACACCCTCCGCCAAGCAGTCCCTGGTCGAC
ATGGCCCCCAAGTACATCCTGGAGCAGTTTCTGCAGCAGGAGCTGCTCATCAACATCACG
GAGCACGAGCTAGTCCCTGAGCACGTCGTCATGACCAAGGAGGAGGTGACAGAGCTGCTG
GCCCGATATAAGCTCCGAGAGAACCAGCTGCCCAGGATCCAGGCGGGGGACCCTGTGGCG
CGCTACTTTGGGATAAAGCGTGGGCAGGTGGTGAAGATCATCCGGCCCAGTGAGACGGCT
GGCAGGTACATCACCTACCGGCTGGTGCAGTAG

# Metabolic_Enzyme_26_GenBank_ID_Gene:
J04965

# Metabolic_Enzyme_26_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_26_Locus:
19p13.3

# Metabolic_Enzyme_26_SNPs:
rs4921; rs12253; rs6843; rs6844; rs1046041; rs2074456; rs3787016; rs10416031; rs12462743; rs11880079; rs7258818; rs12151169; rs12459576; rs2074446; rs11882546; rs2074445; rs2074443; rs10426326; rs11670128; rs1046040; rs2238587; rs1609846; rs2074447; rs11084882; rs2238586; rs11673388; rs2074448; rs8113195; rs17526231; rs2074449; rs12459404; rs11541896; rs11541895; rs11541889; rs36004023; rs10410231; rs11541897; rs35611426; rs10405108; rs35979201; rs35413641; rs35665378; rs2074444; rs36037946; rs41563717; rs34912475; rs41552917; rs34393943; rs7259077; rs34374595; rs34453757; rs10406195; rs17523177; rs5826721; rs8113305; rs17554909; rs17551856; rs35920562; rs41561517; rs17554924; rs17554917; rs10404947; rs10419327; rs10439143; rs1109555; rs11551696; rs11668388; rs11881906; rs11959; rs17526264; rs2074450; rs2074453; rs2074454; rs2074455; rs34047143; rs34569196; rs34593562; rs34721728; rs35124413; rs35646539; rs35843614; rs36084354; rs3746165; rs3746166; rs3761024; rs3761025; rs3761026; rs3761027; rs3761028; rs4239605; rs4588110; rs4806969; rs4806970; rs757228; rs757229; rs757230; rs8103188; rs8113708; rs8178960; rs8178965; rs8178966; rs8178967

# Metabolic_Enzyme_26_General_References:
2753903; 2071613; 7828586

# Metabolic_Enzyme_26_References:
Not Available

# Metabolic_Enzyme_27_ID:
5318

# Metabolic_Enzyme_27_Name:
Ectonucleoside triphosphate diphosphohydrolase 3

# Metabolic_Enzyme_27_Synonyms:
NTPDase 3; Ecto-ATP diphosphohydrolase; ATPDase; Ecto-apyrase; CD39 antigen-like 3; HB6

# Metabolic_Enzyme_27_Gene_Name:
ENTPD3

# Metabolic_Enzyme_27_Protein_Sequence:
>Ectonucleoside triphosphate diphosphohydrolase 3
MFTVLTRQPCEQAGLKALYRTPTIIALVVLLVSIVVLVSITVIQIHKQEVLPPGLKYGIV
LDAGSSRTTVYVYQWPAEKENNTGVVSQTFKCSVKGSGISSYGNNPQDVPRAFEECMQKV
KGQVPSHLHGSTPIHLGATAGMRLLRLQNETAANEVLESIQSYFKSQPFDFRGAQIISGQ
EEGVYGWITANYLMGNFLEKNLWHMWVHPHGVETTGALDLGGASTQISFVAGEKMDLNTS
DIMQVSLYGYVYTLYTHSFQCYGRNEAEKKFLAMLLQNSPTKNHLTNPCYPRDYSISFTM
GHVFDSLCTVDQRPESYNPNDVITFEGTGDPSLCKEKVASIFDFKACHDQETCSFDGVYQ
PKIKGPFVAFAGFYYTASALNLSGSFSLDTFNSSTWNFCSQNWSQLPLLLPKFDEVYARS
YCFSANYIYHLFVNGYKFTEETWPQIHFEKEVGNSSIAWSLGYMLSLTNQIPAESPLIRL
PIEPPVFVGTLAFFTAAALLCLAFLAYLCSATRRKRHSEHAFDHAVDSD

# Metabolic_Enzyme_27_Number_of_Residues:
529

# Metabolic_Enzyme_27_Molecular_Weight:
59106

# Metabolic_Enzyme_27_Theoretical_pI:
6.40

# Metabolic_Enzyme_27_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_27_General_Function:
Not Available

# Metabolic_Enzyme_27_Specific_Function:
Has a threefold preference for the hydrolysis of ATP over ADP

# Metabolic_Enzyme_27_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_27_Reaction:
ATP + 2 H2O = AMP + 2 phosphate

# Metabolic_Enzyme_27_Pfam_Domain_Function:
PF01150:GDA1_CD39

# Metabolic_Enzyme_27_Signals:
1-37

# Metabolic_Enzyme_27_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_27_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_27_EC_Link:
EC 3.6.1.5

# Metabolic_Enzyme_27_GenBank_ID_Protein:
3335100

# Metabolic_Enzyme_27_SwissProt_ID:
ENTP3_HUMAN (O75355)

# Metabolic_Enzyme_27_swissprot_Name:
Not Available

# Metabolic_Enzyme_27_Genecard_id:
ENTPD3

# Metabolic_Enzyme_27_Geneatlas_id:
ENTPD3

# Metabolic_Enzyme_27_hgnc_id:
HGNC:3365

# Metabolic_Enzyme_27_PDB_ID:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_27_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential)

# Metabolic_Enzyme_27_Gene_Sequence:
>1590 bp
ATGTTCACTGTGCTGACCCGCCAACCATGTGAGCAAGCAGGCCTCAAGGCCCTCTACCGA
ACTCCAACCATCATTGCCTTGGTGGTCTTGCTTGTGAGTATTGTGGTACTTGTGAGTATC
ACTGTCATCCAGATCCACAAGCAAGAGGTCCTCCCTCCAGGACTGAAGTATGGTATTGTG
CTGGATGCCGGGTCTTCAAGAACCACAGTCTACGTGTATCAATGGCCAGCAGAAAAAGAG
AATAATACCGGAGTGGTCAGTCAAACCTTCAAATGTAGTGTGAAAGGCTCTGGAATCTCC
AGCTATGGAAATAACCCCCAAGATGTCCCCAGAGCCTTTGAGGAGTGTATGCAAAAAGTC
AAGGGGCAGGTTCCATCCCACCTCCACGGATCCACCCCCATTCACCTGGGAGCCACGGCT
GGGATGCGCTTGCTGAGGTTGCAAAATGAAACAGCAGCTAATGAAGTCCTTGAAAGCATC
CAAAGCTACTTCAAGTCCCAGCCCTTTGACTTTAGGGGTGCTCAAATCATTTCTGGGCAA
GAAGAAGGGGTATATGGATGGATTACAGCCAACTATTTAATGGGAAATTTCCTGGAGAAG
AACCTGTGGCACATGTGGGTGCACCCGCATGGAGTGGAAACCACGGGTGCCCTGGACTTA
GGTGGTGCCTCCACCCAAATATCCTTCGTGGCAGGAGAGAAGATGGATCTGAACACCAGC
GACATCATGCAGGTGTCCCTGTATGGCTACGTATACACGCTCTACACACACAGCTTCCAG
TGCTATGGCCGGAATGAGGCTGAGAAGAAGTTTCTGGCAATGCTCCTGCAGAATTCTCCT
ACCAAAAACCATCTCACCAATCCCTGTTACCCTCGGGATTATAGCATCAGCTTCACCATG
GGCCATGTATTTGATAGCCTGTGCACTGTGGACCAGAGGCCAGAAAGTTATAACCCCAAT
GATGTCATCACTTTTGAAGGAACTGGGGACCCATCTCTGTGTAAGGAGAAGGTGGCTTCC
ATATTTGACTTCAAAGCTTGCCATGATCAAGAAACCTGTTCTTTTGATGGGGTTTATCAG
CCAAAGATTAAAGGGCCATTTGTGGCTTTTGCAGGATTCTACTACACAGCCAGTGCTTTA
AATCTTTCAGGTAGCTTTTCCCTGGACACCTTCAACTCCAGCACCTGGAATTTCTGCTCA
CAGAATTGGAGTCAGCTCCCACTGCTGCTCCCCAAATTTGATGAGGTATATGCCCGCTCT
TACTGCTTCTCAGCCAACTACATCTACCACTTGTTTGTGAACGGTTACAAATTCACAGAG
GAGACTTGGCCCCAAATACACTTTGAAAAAGAAGTGGGGAATAGCAGCATAGCCTGGTCT
CTTGGCTACATGCTCAGCCTGACCAACCAGATCCCAGCTGAAAGCCCTCTGATCCGTCTG
CCCATAGAACCACCTGTCTTTGTGGGCACCCTCGCTTTCTTCACAGTGGCAGCCTTGCTG
TGTCTGGCATTTCTTGCATACCTGTGTTCAGCAACCAGAAGAAAGAGGCACTCCGAGCAT
GCCTTTGACCATGCAGTGGATTCTGACTGA

# Metabolic_Enzyme_27_GenBank_ID_Gene:
AF039917

# Metabolic_Enzyme_27_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_27_Locus:
3p21.3

# Metabolic_Enzyme_27_SNPs:
rs1047855; rs2305521; rs9858868; rs11714871; rs17078798; rs2305522; rs12493020; rs897117; rs1466236; rs6599101; rs6808095; rs9332450; rs6599102; rs954589; rs6783755; rs9848083; rs951560; rs7645864; rs7636719; rs4973999; rs9829800; rs4973997; rs4973898; rs7648952; rs12490249; rs13324109; rs17079011; rs9849348; rs9873394; rs17078941; rs17078813; rs1466237; rs7634375; rs1105745; rs7631893; rs9822909; rs9859026; rs1466238; rs7625736; rs4283549; rs17078812; rs9857824; rs6793596; rs11707673; rs11714032; rs11720360; rs6599100; rs9875245; rs2371185; rs6804157; rs17078914; rs11921197; rs17078916; rs12492035; rs4973994; rs17078921; rs4973989; rs17078959; rs13099333; rs1037516; rs12490275; rs3774805; rs4973998; rs12492777; rs6796122; rs4973993; rs13326389; rs13321169; rs12491944; rs12634013; rs13081891; rs11920596; rs9848049; rs13066971; rs12636697; rs6807397; rs9864380; rs34266806; rs4470483; rs17852714; rs3733167; rs41286046; rs35071108; rs6773917; rs10671439; rs35839072; rs35836679; rs9874499; rs10551054; rs13073943; rs10565031; rs13094752; rs10620040; rs11351492; rs34255517; rs34665572; rs3774806; rs10575365; rs5848563; rs951561; rs13082239; rs3064608; rs11445995; rs9809377; rs35636349; rs35489659; rs4560275; rs6798459; rs10620057; rs13316488; rs13082375; rs6797651; rs6795906; rs13073946; rs3064609; rs41286044; rs35641310; rs35870509; rs13082222; rs13090979; rs9836330; rs34726619; rs28465354; rs10650731; rs9883218; rs9863737; rs9829324; rs1105746; rs5848564; rs9833430; rs9880286; rs9864423; rs3774807; rs28621801; rs34065066; rs6767610; rs11415995; rs3064615; rs35700770; rs5848565; rs9882941; rs34145192; rs34654655; rs10658778; rs11360523; rs9843979; rs36074810; rs9843965; rs13072002; rs35267876; rs41286048; rs9860002; rs9863679; rs13433935; rs35860386; rs9882954; rs11371152; rs9809378; rs28671141; rs28508335; rs34934417; rs6808552; rs10594515; rs9828299; rs1119179; rs12488805; rs12492578; rs12494022; rs2371184; rs6762997; rs6795066; rs7610586; rs7616273; rs7642552; rs9813231; rs9817233; rs9822644; rs9835219; rs9841335; rs9846606; rs9871825; rs9874006; rs9882464

# Metabolic_Enzyme_27_General_References:
9676430; 9675246; 10231536; 11300774

# Metabolic_Enzyme_27_References:
Not Available

# Metabolic_Enzyme_28_ID:
5345

# Metabolic_Enzyme_28_Name:
Nucleoside diphosphate kinase 3

# Metabolic_Enzyme_28_Synonyms:
NDK 3; NDP kinase 3; Nucleoside diphosphate kinase C; NDPKC; nm23-H3; DR-nm23

# Metabolic_Enzyme_28_Gene_Name:
NME3

# Metabolic_Enzyme_28_Protein_Sequence:
>Nucleoside diphosphate kinase 3
MICLVLTIFANLFPAACTGAHERTFLAVKPDGVQRRLVGEIVRRFERKGFKLVALKLVQA
SEELLREHYAELRERPFYGRLVKYMASGPVVAMVWQGLDVVRTSRALIGATNPADAPPGT
IRGDFCIEVGKNLIHGSDSVESARREIALWFRADELLCWEDSAGHWLYE

# Metabolic_Enzyme_28_Number_of_Residues:
169

# Metabolic_Enzyme_28_Molecular_Weight:
19015

# Metabolic_Enzyme_28_Theoretical_pI:
7.97

# Metabolic_Enzyme_28_GO_Classification:
>>>
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  nucleoside diphosphate kinase activity
 ||
>>>
Process:  CTP biosynthesis
Process:  nucleoside triphosphate metabolism
Process:  nucleoside triphosphate biosynthesis
Process:  ribonucleoside triphosphate biosynthesis
Process:  pyrimidine ribonucleoside triphosphate biosynthesis
Process:  UTP biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside triphosphate biosynthesis
Process:  purine ribonucleoside triphosphate biosynthesis
Process:  GTP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_28_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_28_Specific_Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis

# Metabolic_Enzyme_28_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_28_Reaction:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

# Metabolic_Enzyme_28_Pfam_Domain_Function:
PF00334:NDK

# Metabolic_Enzyme_28_Signals:
1-19

# Metabolic_Enzyme_28_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_28_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_28_EC_Link:
EC 2.7.4.6

# Metabolic_Enzyme_28_GenBank_ID_Protein:
1051256

# Metabolic_Enzyme_28_SwissProt_ID:
NDK3_HUMAN (Q13232)

# Metabolic_Enzyme_28_swissprot_Name:
Not Available

# Metabolic_Enzyme_28_Genecard_id:
NME3

# Metabolic_Enzyme_28_Geneatlas_id:
NME3

# Metabolic_Enzyme_28_hgnc_id:
HGNC:7851

# Metabolic_Enzyme_28_PDB_ID:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_28_Subcellular_Location:
Not Available

# Metabolic_Enzyme_28_Gene_Sequence:
>507 bp
ATGATCTGCCTGGTGCTGACCATCTTCGCTAACCTCTTCCCCGCGGCCTGCACCGGCGCA
CACGAACGCACCTTCCTGGCCGTGAAGCCGGACGGCGTGCAGCGGCGGCTGGTGGGCGAG
ATTGTGCGGCGCTTCGAGAGGAAGGGCTTCAAGTTGGTGGCGCTGAAGCTGGTGCAGTCC
TCCGAGGAGCTGCTGCGTGAGCACTACGCCGAGCTGCGTGAACGCCCGTTCTACGGCCGC
CTTGTCAAGTATATGGCCTCCGGGCCGGTGGTGGCCATGGTTTGGCAGGGGCTGGACGTG
GTGCGCACCTCGCGGGCGCTCATCGGAGCCACGAACCCGGCCGACGCCCCGCCCGGCACC
ATCCGCGGGGATTTCTGCATCGAGGTTGGCAACCTGATTCACGGCAGCGACTCGGTGGAG
AGTGCCCGCCGCGAGATCGCTCTCTGGTTCCGCGCAGACGAGCTCCTCTGCTGGGAGGAC
AGCGCTGGGCACTGGCTGTATGAGTAG

# Metabolic_Enzyme_28_GenBank_ID_Gene:
U29656

# Metabolic_Enzyme_28_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_28_Locus:
16q13

# Metabolic_Enzyme_28_SNPs:
Not Available

# Metabolic_Enzyme_28_General_References:
7638209; 11157797

# Metabolic_Enzyme_28_References:
Not Available

# Metabolic_Enzyme_29_ID:
6026

# Metabolic_Enzyme_29_Name:
DNA-directed RNA polymerase II 7.6 kDa polypeptide

# Metabolic_Enzyme_29_Synonyms:
RPB10; RPB7.6; RPABC5

# Metabolic_Enzyme_29_Gene_Name:
POLR2L

# Metabolic_Enzyme_29_Protein_Sequence:
>DNAdirected RNA polymerase II 7.6 kDa polypeptide
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

# Metabolic_Enzyme_29_Number_of_Residues:
67

# Metabolic_Enzyme_29_Molecular_Weight:
7645

# Metabolic_Enzyme_29_Theoretical_pI:
7.92

# Metabolic_Enzyme_29_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_29_General_Function:
Transcription 

# Metabolic_Enzyme_29_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

# Metabolic_Enzyme_29_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_29_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_29_Pfam_Domain_Function:
PF01194:RNA_pol_N

# Metabolic_Enzyme_29_Signals:
None

# Metabolic_Enzyme_29_Transmembrane_Regions:
None

# Metabolic_Enzyme_29_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_29_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_29_GenBank_ID_Protein:
1017825

# Metabolic_Enzyme_29_SwissProt_ID:
RPB10_HUMAN (P62875)

# Metabolic_Enzyme_29_swissprot_Name:
Not Available

# Metabolic_Enzyme_29_Genecard_id:
POLR2L

# Metabolic_Enzyme_29_Geneatlas_id:
POLR2L

# Metabolic_Enzyme_29_hgnc_id:
HGNC:9199

# Metabolic_Enzyme_29_PDB_ID:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_29_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_29_Gene_Sequence:
>204 bp
ATGATCATCCCTGTACGCTGCTTCACTTGTGGCAAGATCGTCGGCAACAAGTGGGAGGCT
TACCTGGGGCTGCTGCAGGCCGAGTACACCGAGGGGGACGCGCTGGATGCCCTGGGCCTG
AAGCGCTACTGCTGCCGCCGGATGCTGCTGGCCCACGTGGACCTGATCGAGAAGCTGCTC
AATTATGCACCCCTGGAGAAGTGA

# Metabolic_Enzyme_29_GenBank_ID_Gene:
U37690

# Metabolic_Enzyme_29_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_29_Locus:
11p15

# Metabolic_Enzyme_29_SNPs:
rs17416106; rs6591; rs3059; rs35161470; rs34019196; rs34038805; rs34704315; rs11629; rs35905666; rs34230160; rs28677123; rs34627090; rs28636471; rs34789402; rs28735718; rs11246326; rs3210212; rs3210213; rs35835984; rs11246327; rs28551040; rs35832719; rs28692469; rs34052643; rs34940311; rs10902225; rs10902227; rs11246324; rs11246332; rs1130663; rs1130680; rs1130698; rs1130703; rs1130709; rs1130714; rs12222600; rs12577118; rs12577894; rs1803956; rs1803958; rs28612689; rs28620453; rs34284407; rs4075289; rs4075290; rs4963144; rs5030780; rs6597975; rs6597977; rs6762; rs7924806; rs7933720; rs7946756; rs8672; rs9704919; rs9704922; rs9705236

# Metabolic_Enzyme_29_General_References:
8524256; 7651387

# Metabolic_Enzyme_29_References:
Not Available

# Metabolic_Enzyme_30_ID:
6027

# Metabolic_Enzyme_30_Name:
DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide

# Metabolic_Enzyme_30_Synonyms:
RNA polymerase III subunit 2; RPC2

# Metabolic_Enzyme_30_Gene_Name:
POLR3B

# Metabolic_Enzyme_30_Protein_Sequence:
>DNAdirected RNA polymerase III subunit 127.6 kDa polypeptide
MDVLAEEFGNLTPEQLAAPIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMK
ANEKVTSDADPMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIEYT
RGSQRIIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLDPGGYFIVKGVEKVILI
QEQLSKNRIIVEADRKGAVGASVTSSTHEKKSRTNMAVKQGRFYLRHNTLSEDIPIVIIF
KAMGVESDQEIVQMIGTEEHVMAAFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGG
PKKTKIEEARELLASTILTHVPVKEFNFRAKCIYTAVMVRRVILAQGDNKVDDRDYYGNK
RLELAGQLLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAIS
TGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLC
PSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVF
LNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVK
KQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIE
PFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMV
KTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLK
RYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPL
EGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSR
HGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHY
GTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKM
HARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVC
GQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKLSKYNE

# Metabolic_Enzyme_30_Number_of_Residues:
1133

# Metabolic_Enzyme_30_Molecular_Weight:
127787

# Metabolic_Enzyme_30_Theoretical_pI:
8.64

# Metabolic_Enzyme_30_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_30_General_Function:
Transcription 

# Metabolic_Enzyme_30_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

# Metabolic_Enzyme_30_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_30_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_30_Pfam_Domain_Function:
PF04563:RNA_pol_Rpb2_1;
PF04561:RNA_pol_Rpb2_2;
PF04565:RNA_pol_Rpb2_3;
PF04566:RNA_pol_Rpb2_4;
PF04567:RNA_pol_Rpb2_5;
PF00562:RNA_pol_Rpb2_6;
PF04560:RNA_pol_Rpb2_7

# Metabolic_Enzyme_30_Signals:
None

# Metabolic_Enzyme_30_Transmembrane_Regions:
None

# Metabolic_Enzyme_30_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_30_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_30_GenBank_ID_Protein:
24429617

# Metabolic_Enzyme_30_SwissProt_ID:
RPC2_HUMAN (Q9NW08)

# Metabolic_Enzyme_30_swissprot_Name:
Not Available

# Metabolic_Enzyme_30_Genecard_id:
POLR3B

# Metabolic_Enzyme_30_Geneatlas_id:
POLR3B

# Metabolic_Enzyme_30_hgnc_id:
HGNC:30348

# Metabolic_Enzyme_30_PDB_ID:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_30_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_30_Gene_Sequence:
>3402 bp
ATGGACGTGCTAGCGGAGGAGTTTGGGAACCTGACTCCGGAGCAGCTGGCGGCGCCGATC
CCGACTGTAGAGGAAAAATGGAGGCTGCTTCCAGCATTTTTAAAGGTGAAAGGCCTTGTG
AAACAGCATATAGATTCATTTAACTATTTCATTAATGTAGAGATAAAGAAGATAATGAAA
GCCAATGAAAAGGTTACAAGTGACGCTGACCCTATGTGGTACTTAAAATATCTTAATATC
TATGTTGGGCTTCCTGATGTTGAAGAAAGCTTCAATGTAACTAGACCAGTGTCCCCTCAT
GAGTGCCGTTTGAGAGACATGACATACTCTGCCCCTATTACAGTGGATATTGAATATACC
CGAGGCAGCCAGAGGATCATCCGCAATGCCTTACCTATCGGCAGAATGCCCATAATGCTA
CGTAGTTCAAACTGTGTTCTTACAGGAAAAACGCCAGCAGAATTTGCCAAACTGAACGAA
TGTCCCTTAGATCCAGGTGGCTACTTCATTGTTAAAGGAGTAGAAAAAGTTATTCTTATC
CAAGAGCAGCTGTCTAAGAACAGGATCATCGTGGAGGCTGATAGAAAAGGGGCTGTTGGA
GCTTCAGTTACCAGCTCTACCCATGAGAAAAAAAGCAGAACCAATATGGCTGTGAAACAA
GGACGATTTTATTTGAGGCATAATACTTTGTCAGAAGATATACCCATTGTCATCATATTT
AAGGCCATGGGTGTTGAGAGTGACCAGGAAATTGTGCAGATGATTGGAACAGCGGAGCAC
GTGATGGCTGCATTTGGGCCCAGTCTGGAAGAGTGCCAGAAAGCTCAGATTTTCACACAG
ATGCAGGCATTAAAATATATAGGGAACAAAGTAAGAAGGCAAAGGATGTGGGGAGGTGGA
CCAAAGAAAACCAAAATAGAAGAAGCAAGAGAGCTCCTGGCTTCCACCATTCTGACCCAT
GTCCCAGTTAAGGAATTCAATTTCCGAGCCAAATGTATCTATACTGCAGTGATGGTGCGA
AGAGTTATTCTGGCCCAAGGAGATAATAAAGTTGACGACAGAGATTATTATGGTAACAAG
CGACTGGAATTGGCAGGACAGCTTTTATCTCTTCTTTTTGAAGACTTGTTCAAAAAATTT
AATTCTGAAATGAAAAAGATTGCCGACCAGGTGATTCCTAAGCAAAGAGCAGCCCAGTTT
GATGTTGTCAAACACATGCGCCAAGACCAGATCACCAATGGCATGGTGAATGCTATTTCT
ACCGGAAATTGGTCTTTAAAGAGATTTAAAATGGACCGCCAGGGTGTAACCCAAGTGCTG
TCTCGCTTGTCATATATATCCGCACTGGGCATGATGACAAGAATCTCTTCCCAGTTTGAA
AAAACGAGAAAAGTGAGTGGTCCTCGCTCCCTCCAGCCATCTCAGTGGGGAATGCTGTGT
CCTTCGGACACTCCTGAAGGAGAGGCATGTGGTTTGGTTAAAAACTTGGCCCTTATGACA
CACATCACAACTGATATGGAAGATGGACCCATTGTTAAATTAGCCAGTAACTTGGGAGTA
GAAGATGTGAATTTATTATGTGGGGAAGAGCTCTCTTACCCAAATGTGTTTCTTGTCTTT
CTTAATGGTAACATCTTAGGTGTCATTCGAGACCACAAAAAGCTAGTGAATACATTTCGA
CTCATGAGAAGAGCAGGATATATCAATGAATTTGTTTCCATCTCAACAAATCTTACAGAT
CGATGTGTCTATATTTCTTCTGATGGGGGAAGGCTATGCAGACCCTACATAATTGTCAAG
AAACAGAAGCCAGCAGTCACAAATAAACATATGGAAGAGCTGGCCCAAGGGTACAGGAAT
TTTGAAGATTTCTTACATGAGAGTCTGGTTGAATATTTAGATGTGAATGAAGAAAATGAT
TGTAACATTGCACTGTACGAACACACAATTAATAAAGACACCACCCACTTGGAGATTGAA
CCCTTCACTCTTCTCGGCGTGTGTGCTGGACTTATCCCATACCCTCACCATAACCAGTCA
CCGAGAAACACTTATCAGTGTGCCATGGGGAAACAAGCCATGGGTACTATAGGATACAAC
CAGCGAAACAGAATTGATACTCTCATGTATCTACTAGCATATCCACAAAAACCCATGGTT
AAGACAAAAACCATTGAATTGATAGAATTTGAGAAACTGCCAGCTGGACAGAATGCAACA
GTTGCTGTGATGAGCTATAGTGGCTATGATATTGAAGATGCTCTTGTTTTAAACAAGGCC
TCTTTAGACAGAGGCTTTGGGCGTTGCCTTGTATATAAAAATGCTAAATGTACGTTGAAA
CGATACACCAATCAGACTTTTGATAAAGTGATGGGGCCCATGTTGGATGCTGCTACAAGG
AAACCTATCTGGCGACATGAAATCTTAGATGCAGATGGTATTTGTTCTCCAGGTGAGAAA
GTAGAAAACAAACAAGTGCTTGTAAATAAGTCCATGCCCACAGTGACTCAGATTCCTTTG
GAAGGAAGTAATGTACCACAGCAACCACAGTACAAAGATGTACCCATAACCTACAAAGGA
GCAACAGACTCATATATTGAAAAAGTGATGATATCTTCAAATGCTGAAGATGCTTTTCTG
ATCAAAATGCTGCTGAGACAGACAAGGCGTCCAGAAATTGGAGACAAATTCAGCAGTCGT
CATGGGCAAAAAGGTGTTTGTGGCTTGATCGTCCCCCAGGAAGACATGCCATTTTGTGAT
TCTGGCATCTGTCCGGACATCATCATGAACCCACACGGCTTCCCATCACGAATGACGGTG
GGGAAGCTCATTGAGCTGCTGGCTGGCAAGGCCGGTGTGCTGGACGGCAGATTCCACTAC
GGCACTGCGTTTGGAGGCAGTAAAGTGAAGGATGTGTGTGAGGACCTCGTTCGCCATGGT
TATAACTACTTGGGGAAAGACTATGTTACATCCGGCATCACAGGTGAGCCCTTAGAAGCA
TACATCTATTTTGGCCCCGTGTACTATCAGAAGCTGAAACACATGGTGCTAGATAAAATG
CATGCCCGGGCCCGGGGCCCACGAGCCGTCCTTACCAGGCAACCCACTGAAGGACGGTCT
CGTGATGGTGGCTTGCGTCTCGGGGAAATGGAACGTGACTGTTTAATCGGTTATGGAGCC
AGTATGCTTTTGCTAGAGAGACTAATGATTTCAAGTGATGCCTTTGAGGTTGATGTCTGT
GGGCAGTGTGGACTTCTGGGGTATTCTGGCTGGTGCCATTACTGCAAGTCATCCTGCCAC
GTGTCTTCCCTCCGTATTCCGTATGCCTGCAAGCTGCTCTTCCAGGAACTACAGTCTATG
AACATCATCCCCAGGTTAAAACTGTCCAAGTACAATGAATGA

# Metabolic_Enzyme_30_GenBank_ID_Gene:
AY092084

# Metabolic_Enzyme_30_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_30_Locus:
12q23.3

# Metabolic_Enzyme_30_SNPs:
rs17038460; rs13561; rs10861607; rs17038450; rs2288266; rs2900500; rs2246353; rs2245062; rs1882413; rs10861595; rs10861580; rs10778477; rs4625578; rs10861583; rs11113012; rs6539268; rs10778482; rs10861585; rs10778468; rs10861587; rs11112983; rs11112977; rs6539271; rs7134615; rs7969743; rs10047654; rs4964175; rs6539269; rs3851631; rs7135054; rs7297873; rs10778474; rs10778478; rs2288270; rs10861605; rs7965520; rs3851633; rs7139139; rs10861592; rs10778466; rs10861582; rs10861613; rs6539267; rs10507211; rs10778465; rs11831881; rs11831101; rs10778470; rs10778471; rs10861586; rs10861597; rs7306326; rs10746060; rs11615682; rs11113011; rs10778473; rs2243506; rs7316730; rs2250262; rs10861588; rs2255008; rs10861603; rs3851634; rs2249162; rs7137271; rs10861593; rs10861598; rs12318744; rs3851635; rs1004601; rs11112980; rs12298876; rs7313040; rs2249773; rs11611176; rs6539270; rs7139249; rs10861591; rs7298062; rs11829364; rs11112952; rs11112976; rs7137445; rs10861601; rs7296090; rs2141775; rs2465355; rs11113009; rs12424092; rs10861600; rs11834714; rs10861594; rs721438; rs7301694; rs10861604; rs2374610; rs12305705; rs7308541; rs2244958; rs7137444; rs7303873; rs12300729; rs7315549; rs12316795; rs11112993; rs12423068; rs7137638; rs10861590; rs10778480; rs11112999; rs11112951; rs2900499; rs11835357; rs10861608; rs7309020; rs4964465; rs2141774; rs2264759; rs11613906; rs2249772; rs17221107; rs7134881; rs6539272; rs11112990; rs10861606; rs7955001; rs7311957; rs12312915; rs10778469; rs11609315; rs7302051; rs2254755; rs10861581; rs2288268; rs7298709; rs11611252; rs7971581; rs12581541; rs10861614; rs12226958; rs10444532; rs17038414; rs17285274; rs12301022; rs11113006; rs11112965; rs11112964; rs2249787; rs7307745; rs11112979; rs2250653; rs12309758; rs10861584; rs7315057; rs12369268; rs12423009; rs10778472; rs12814523; rs7962132; rs7294857; rs12581804; rs10861589; rs11835362; rs7962041; rs2374609; rs10161297; rs7956775; rs12309708; rs11112995; rs11112950; rs2250621; rs9705924; rs7299017; rs12368924; rs7298721; rs7976623; rs11113013; rs7970973; rs10861612; rs7136098; rs17038386; rs7298708; rs12823974; rs9739759; rs7310037; rs4964463; rs12425459; rs7314428; rs2288269; rs11113005; rs2264812; rs10861599; rs10778481; rs2713727; rs11113015; rs11612606; rs7310703; rs11837827; rs12318640; rs11612605; rs11113016; rs12307619; rs11112982; rs7315067; rs12581524; rs2264758; rs11113003; rs12316214; rs17038461; rs11112957; rs17286995; rs11112997; rs12231768; rs7315733; rs3851632; rs10746059; rs11112953; rs11831070; rs11610483; rs7979127; rs11611815; rs7313461; rs2243531; rs7132744; rs35983209; rs7133068; rs17219334; rs3217286; rs12810127; rs35349709; rs11112984; rs35608186; rs11112967; rs10654233; rs33954279; rs35052168; rs11341760; rs12320538; rs34405326; rs12302752; rs12819520; rs10685028; rs11112994; rs11503257; rs12315397; rs12296777; rs2465357; rs34701528; rs12296124; rs12426205; rs2704902; rs34162441; rs9706281; rs12316278; rs11429763; rs35084532; rs35176336; rs34013979; rs12372552; rs12425564; rs7398088; rs12308628; rs34153455; rs34954906; rs7300948; rs11113014; rs11112986; rs34234806; rs34881430; rs34915594; rs12302008; rs11112949; rs4378483; rs11113004; rs12296118; rs12322877; rs35162864; rs35577793; rs7963514; rs7978568; rs11533557; rs12369273; rs12312357; rs34495023; rs7959086; rs11112963; rs11829394; rs35814113; rs11372086; rs5800711; rs10647733; rs35398082; rs11112991; rs17038405; rs34726608; rs7306277; rs12297781; rs12312644; rs35229993; rs34510124; rs4964464; rs12304010; rs11112956; rs7295582; rs12818349; rs11384739; rs35512078; rs12307507; rs34402190; rs11112961; rs12229913; rs7294432; rs7303942; rs7962022; rs1230146; rs34619628; rs34274773; rs28826960; rs34411830; rs35609363; rs7301296; rs11113010; rs10690683; rs34955444; rs36044956; rs35458117; rs2264760; rs2288267; rs35090518; rs34134371; rs7963078; rs34855793; rs12301150; rs10594990; rs11112970; rs34003994; rs7962691; rs35419609; rs11112954; rs2374606; rs10712889; rs4447260; rs11112960; rs12423019; rs35702527; rs2249623; rs12309290; rs12818336; rs11113007; rs33998449; rs9668416; rs12821178; rs35334189; rs11112958; rs35588880; rs17038455; rs34217457; rs34623920; rs35207683; rs12819009; rs12822057; rs12317819; rs12810126; rs12309432; rs3759308; rs12313696; rs11112972; rs35950924; rs11112973; rs35596912; rs11112978; rs11320428; rs11112988; rs11112992; rs12424939; rs10861602; rs12818343; rs35438232; rs34053178; rs12579099; rs4512944; rs2704901; rs34808962; rs7297673; rs35384595; rs11112981; rs11112959; rs7298681; rs35038433; rs11835700; rs12307154; rs7301534; rs1578965; rs12300331; rs35710260; rs35295387; rs7971666; rs12314219; rs12322722; rs12320678; rs34567307; rs35671254; rs11112955; rs35435397; rs11112975; rs34399991; rs11370235; rs12810363; rs35529681; rs34269741; rs12307632; rs11112962; rs34726249; rs7968995; rs35624865; rs11112969; rs35425821; rs35920071; rs34904813; rs11112989; rs35265815; rs10633183; rs35463953; rs7297981; rs11112971; rs34981102; rs11351722; rs34565634; rs7976811; rs11112985; rs12580542; rs36096330; rs7136383; rs35244110; rs3782705; rs4479082; rs5800710; rs2713728; rs34444680; rs11113008; rs35670119; rs11112968; rs7298462; rs35041875; rs10573617; rs10572620; rs10572619; rs35612793; rs10778464; rs10778475; rs10778476; rs10778483; rs10778484; rs10861609; rs10861615; rs10861616; rs11112948; rs11113002; rs11113021; rs11113023; rs11833143; rs12301581; rs12302439; rs12303491; rs12306924; rs12322062; rs1234972; rs12578405; rs12581936; rs12823029; rs1317188; rs17038484; rs1921954; rs2252685; rs34681274; rs35285105; rs3902141; rs4522273; rs6650215; rs7299021; rs7303737; rs7306012; rs7315611; rs741624; rs7955326; rs7956753; rs7957739; rs7963213; rs7976305

# Metabolic_Enzyme_30_General_References:
12391170

# Metabolic_Enzyme_30_References:
Not Available

# Metabolic_Enzyme_31_ID:
6028

# Metabolic_Enzyme_31_Name:
DNA-directed RNA polymerase III subunit F

# Metabolic_Enzyme_31_Synonyms:
DNA-directed RNA polymerase III 39 kDa polypeptide; RNA polymerase III C39 subunit

# Metabolic_Enzyme_31_Gene_Name:
POLR3F

# Metabolic_Enzyme_31_Protein_Sequence:
>DNAdirected RNA polymerase III subunit 
FMAEVKVKVQPPDADPVEIENRIIELCHQFPHGITDQVIQNEMPHIEAQQRAVAINRLLS
MGQLDLLRSNTGLLYRIKDSQNAGKMKGSDNQEKLVYQIIEDAGNKGIWSRDIRYKSNLP
LTEINKILKNLESKKLIKAVKSVAASKKKVYMLYNLQPDRSVTGGAWYSDQDFESEFVEV
LNQQCFKFLQSKAETARESKQNPMIQRNSSFASSHEVWKYICELGISKVELSMEDIETIL
NTLIYDGKVEMTIIAAKEGTVGSVDGHMKLYRAVNPIIPPTGLVRAPCGLCPVFDDCHEG
GEISPSNCIYMTEWLEF

# Metabolic_Enzyme_31_Number_of_Residues:
316

# Metabolic_Enzyme_31_Molecular_Weight:
35684

# Metabolic_Enzyme_31_Theoretical_pI:
6.00

# Metabolic_Enzyme_31_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Metabolic_Enzyme_31_General_Function:
Not Available

# Metabolic_Enzyme_31_Specific_Function:
This subunit may direct RNA Pol III binding to the TFIIIB-DNA complex

# Metabolic_Enzyme_31_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_31_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_31_Pfam_Domain_Function:
PF05158:RNA_pol_Rpc34

# Metabolic_Enzyme_31_Signals:
None

# Metabolic_Enzyme_31_Transmembrane_Regions:
None

# Metabolic_Enzyme_31_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_31_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_31_GenBank_ID_Protein:
2228752

# Metabolic_Enzyme_31_SwissProt_ID:
RPO3F_HUMAN (Q9H1D9)

# Metabolic_Enzyme_31_swissprot_Name:
Not Available

# Metabolic_Enzyme_31_Genecard_id:
POLR3F

# Metabolic_Enzyme_31_Geneatlas_id:
POLR3F

# Metabolic_Enzyme_31_hgnc_id:
HGNC:15763

# Metabolic_Enzyme_31_PDB_ID:
Not Available

# Metabolic_Enzyme_31_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_31_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_31_Subcellular_Location:
Nucleus (Potential)

# Metabolic_Enzyme_31_Gene_Sequence:
>954 bp
ATGGGCGAGGTGAAGGTGAAGGTGCAGCCGCCTGACGCCGATCCGGTCGAAATAGAAAAC
AGGATTATAGAATTATGTCACCAGTTCCCTCATGGAATCACAGACCAAGTAATTCAGAAT
GAAATGCCTCAATATAGAAGCCCAGCAGCGGGCAGTAGCATCAATAGGTTGTTGTCTATG
GGTCAGTTGGATCTCTTAAGGAGCAATACGGGCCTTTTATATAGAATAAAGGACTCTCAG
AATGCTGGTAAAATGAAGGGATCCGATAACCAAGAAAAACTAGTATATCAAATCATAGAG
GATGCAGGAAATAAAGGAATATGGAGCAGAGATATCCGCTATAAAAGTAATTTGCCATTA
ACAGAAATCAACAAAATTCTGAAGAATCTGGAAAGTAAAAAGCTTATCAAAGCTGTTAAG
TCTGTAGCAGCCTCAAAAAAGAAGGTGTATATGCTCTATAACCTGCAGCCAGACCGGTCT
GTGACTGGTGGAGCCTGGTACAGTGACCAGGATTTTGAATCTGAATTTGTAGAGGTGCTT
AACCAACAGTGTTTTAAATTCCTACAGTCCAAGGCAGAAACAGCACGAGAAAGCAAACAG
AACCCAATGATACAAAGAAATAGTTCATTTGCCTCATCACATGAAGTGTGGAAATATATC
TGCGAATTGGGAATCAGTAAGGTAGAGTTATCCATGGAAGACATTGAAACCATCCTGAAT
ACACTCATTTATGATGGAAAAGTGGAGATGACGATTATTGCCTGCAAAAGAAGGCACAGT
TGGCAGTGTAGATGGACACATGAAACTGTACAGGGCAGTCAATCCAATCATCCCTCCCAC
AGGTTTGGTCCGGGCCACCCTGTGGACTCTGCCCCGGTTTTTGATGACTGCCACGAAGGT
GGTGAGATTTCACCATCTAACTGTATTTACATGACAGAGTGGCTCGAATTTTAA

# Metabolic_Enzyme_31_GenBank_ID_Gene:
U93869

# Metabolic_Enzyme_31_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_31_Locus:
20p11.23

# Metabolic_Enzyme_31_SNPs:
rs1055171; rs36071991; rs34900852; rs1055177; rs5867; rs1133724; rs2424208; rs4813332; rs2145229; rs6081160; rs6111983; rs6045426; rs1988646; rs6035052; rs2424211; rs6111982; rs6075344; rs6035056; rs2424212; rs6045427; rs3762197; rs6081158; rs16979233; rs2424213; rs6081159; rs6111979; rs6081157; rs2424209; rs6111981; rs3827965; rs2424210; rs6105927; rs11907020; rs4814751; rs7269669; rs11696965; rs6035055; rs3790148; rs8117523; rs6045431; rs4814752; rs11544222; rs6136386; rs6136387; rs1133696; rs6111986; rs41276440; rs1804852; rs1055179; rs2424214; rs6111985; rs1055175; rs35052739; rs6081155; rs16979236; rs6132065; rs6045429; rs6136385; rs6081153; rs6045422; rs6035054; rs28584295; rs11476411; rs11306906; rs11905111; rs6045423; rs11908275; rs16979229; rs2424207; rs6105928; rs11276794; rs35296606; rs6081156; rs35335580; rs6111978; rs12625658; rs6045421; rs6035053; rs6111984; rs10623960; rs11482124; rs6132066; rs11905483; rs6045424; rs11472141; rs6045430; rs6075345; rs2424215; rs11087256; rs11906101; rs12625681; rs1474974; rs17734179; rs17734238; rs17806832; rs2180660; rs2277863; rs2424204; rs2424205; rs2424217; rs2424218; rs3748449; rs4264617; rs4814753; rs6035047; rs6035051; rs6035062; rs6045418; rs6045435; rs6075343; rs6075348; rs6081150; rs6081151; rs6111989; rs6111991; rs6136383; rs7262655; rs8114219; rs8117215

# Metabolic_Enzyme_31_General_References:
9171375; 11780052; 10523658

# Metabolic_Enzyme_31_References:
Not Available

# Metabolic_Enzyme_32_ID:
5949

# Metabolic_Enzyme_32_Name:
CTP synthase 1

# Metabolic_Enzyme_32_Synonyms:
UTP--ammonia ligase 1; CTP synthetase 1

# Metabolic_Enzyme_32_Gene_Name:
CTPS

# Metabolic_Enzyme_32_Protein_Sequence:
>CTP synthase 1
MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFV
LDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDA
IQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHV
SLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQ
VICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCS
IALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSADLEPITSQEEPVRYHEAWQK
LCSAHGVLVPGGFGVRGTEGKIQAIAWARNQKKPFLGVCLGMQLAVVEFSRNVLGWQDAN
STEFDPTTSHPVVVDMPEHNPGQMGGTMRLGKRRTLFQTKNSVMRKLYGDADYLEERHRH
RFEVNPVWKKCLEEQGLKFVGQDVEGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPY
FGLLLASVGRLSHYLQKGCRLSPRDTYSDRSGSSSPDSEITELKFPSINHD

# Metabolic_Enzyme_32_Number_of_Residues:
591

# Metabolic_Enzyme_32_Molecular_Weight:
66691

# Metabolic_Enzyme_32_Theoretical_pI:
6.42

# Metabolic_Enzyme_32_GO_Classification:
>>>
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  CTP synthase activity
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  pyrimidine nucleotide metabolism
Process:  pyrimidine nucleotide biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_32_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_32_Specific_Function:
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

# Metabolic_Enzyme_32_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_32_Reaction:
ATP + UTP + NH3 = ADP + phosphate + CTP

# Metabolic_Enzyme_32_Pfam_Domain_Function:
PF06418:CTP_synth_N;
PF00117:GATase

# Metabolic_Enzyme_32_Signals:
None

# Metabolic_Enzyme_32_Transmembrane_Regions:
None

# Metabolic_Enzyme_32_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_32_EC_Link:
EC 6.3.4.2

# Metabolic_Enzyme_32_GenBank_ID_Protein:
30293

# Metabolic_Enzyme_32_SwissProt_ID:
PYRG1_HUMAN (P17812)

# Metabolic_Enzyme_32_swissprot_Name:
Not Available

# Metabolic_Enzyme_32_Genecard_id:
CTPS

# Metabolic_Enzyme_32_Geneatlas_id:
CTPS

# Metabolic_Enzyme_32_hgnc_id:
HGNC:2519

# Metabolic_Enzyme_32_PDB_ID:
Not Available

# Metabolic_Enzyme_32_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_32_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_32_Subcellular_Location:
Not Available

# Metabolic_Enzyme_32_Gene_Sequence:
>1776 bp
ATGAAGTACATTCTGGTTACTGGTGGTGTTATATCAGGAATTGGAAAAGGAATCATTGCC
AGCAGTGTGGGCACAATACTCAAGTCATGTGGTTTACATGTAACTTCAATCAAAATTGAC
CCCTACATTAACATTGATGCAGGAACATTCTCTCCTTATGAGCATGGTGAGGTTTTTGTG
CTGGATGATGGTGGGGAAGTAGACCTTGACCTGGGTAACTATGAGCGGTTCCTTGACATC
CGCCTCACCAAGGACAATAATCTGACCACTGGAAAGATATACCAGTATGTCATTAACAAG
GAACGGAAAGGAGATTACTTGGGGAAAACTGTCCAAGTTGTCCCTCATATCACAGATGCA
ATCCAGGAGTGGGTGATGAGACAGGCGTTAATACCTGTAGATGAAGATGGCCTGGAACCT
CAAGTGTGTGTTATTGAGCTTGGTGGAACCGTGGGGGACATAGAAAGCATGCCCTTTATT
GAGGCCTTCCGTCAGTTCCAATTCAAGGTCAAAAGAGAGAACTTTTGTAACATCCACGTC
AGTCTAGTTCCCCAGCCAAGTTCAACAGGGGAACAGAAGACTAAACCTACCCAGAATAGT
GTTCGGGAACTTAGAGGACTTGGGCTTTCCCCAGATCTGGTTGTATGCAGGTGCTCAAAT
CCACTTGACACATCAGTGAAGGAGAAAATATCAATGTTCTGCCATGTTGAGCCTGAACAA
GTGATCTGTGTCCACGATGTCTCATCCATCTACCGAGTCCCCTTGTTGTTAGAGGAGCAA
GGGGTTGTAGATTATTTTCTTCGAAGACTTGACCTTCCTATTGAGAGGCAGCCAAGAAAA
ATGCTGATGAAATGGAAAGAGATGGCTGACAGATATGATCGCTTGCTGGAGACCTGCTCT
ATTGCCCTTGTGGCGAAATACACCGAGTTCTCAGACTCCTATGCCTCTGTCATTAAGGCT
CTGGAGCATTCTGCACTGGCCATCAACCACAAATTGGAAATCAAGTACATAGATTCTGCG
GACTTGGAGCCCATCACCTCGCAAGAAGAGCCCGTGCGCTACCACGAAGCTTGGCAGAAG
CTCTGTAGTGCTCATGGAGTGCTGGTTCCAGGAGGATTTGGTGTTCGAGGAACAGAAGGA
AAAATCCAAGCAATTGCCTGGGCTCGGAATCAGAAAAAGCCTTTTTTGGGCGTGTGCTTA
GGGATGCAGTTGGCAGTGGTTGAATTCTCAAGAAACGTGCTGGGATGGCAAGATGCCAAT
TCTACAGAGTTTGACCCTACGACCAGTCATCCCGTGGTCGTAGACATGCCAGAACACAAC
CCAGGGCAGATGGGCGGAACCATGAGGCTGGGCAAGAGGAGAACCCTGTTCCAGACCAAG
AACTCAGTCATGAGGAAACTCTATGGAGACGCAGACTACTTGGAAGAGAGGCACCGCCAC
CGATTTGAGGTGAATCCAGTCTGGAAAAAGTGTTTGGAAGAACAAGGCTTGAAGTTTGTT
GGCCAAGATGTTGAAGGAGAGAGAATGGAAATTGTGGAGTTAGAAGATCATCCCTTTTTT
GTTGGGGTTCAGTACCACCCTGAGTTCCTGTCCAGGCCTATCAAGCCCTCCCCACCATAC
TTTGGCCTCCTCCTGGCCTCTGTGGGGCGGCTCTCACATTACCTCCAGAAAGGCTGCAGG
CTCTCACCCAGGGACACCTATAGTGACAGGAGTGGAAGCAGCTCCCCTGACTCTGAAATC
ACCGAACTGAAGTTTCCATCAATAAATCATGACTGA

# Metabolic_Enzyme_32_GenBank_ID_Gene:
X52142

# Metabolic_Enzyme_32_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_32_Locus:
1p34.1

# Metabolic_Enzyme_32_SNPs:
rs4363414; rs16827810; rs7546898; rs11577910; rs11209315; rs7512775; rs12410005; rs12410096; rs12718433; rs11209342; rs12408576; rs4132438; rs6600363; rs4132440; rs7523029; rs6600362; rs7535802; rs11209331; rs3922676; rs4364871; rs7537689; rs4453027; rs12047657; rs12044786; rs35044078; rs4430318; rs12735455; rs12743340; rs13376450; rs12731155; rs4132439; rs12144160; rs11209347; rs12047078; rs12023079; rs2897231; rs2897230; rs12729920; rs3935871; rs35240983; rs17856308; rs11541594; rs36007898; rs34761170; rs5030799; rs33963815; rs11316628; rs12736067; rs5030801; rs35846227; rs34730648; rs5030800; rs7543690; rs11209312; rs4130828; rs12135912; rs6675122; rs12145744; rs12749196; rs34316011; rs34538426; rs12135364; rs35080169; rs34043964; rs35160190; rs12119675; rs4660497; rs5773721; rs35156226; rs35281195; rs28469640; rs11209349; rs12027691; rs4660496; rs12739052; rs4660182; rs11580414; rs35368773; rs34472412; rs41308258; rs11343566; rs28401673; rs34502739; rs12748235; rs6675165; rs12061505; rs34406683; rs4548429; rs36057096; rs41268101; rs12738189; rs12724936; rs12090358; rs1892553; rs12079825; rs12132595; rs3206609; rs34209541; rs10789262; rs11209361; rs11209363; rs1129661; rs1138293; rs11579483; rs11579485; rs11584051; rs12033893; rs12033917; rs12033920; rs12121539; rs12736566; rs17357905; rs17357954; rs34386830; rs35405087; rs36084778; rs3738368; rs3738369; rs4360513; rs4440845; rs4660498; rs6661890; rs6674450; rs6685430; rs7534059

# Metabolic_Enzyme_32_General_References:
2113467

# Metabolic_Enzyme_32_References:
Not Available

# Metabolic_Enzyme_33_ID:
6029

# Metabolic_Enzyme_33_Name:
DNA-directed RNA polymerase II 33 kDa polypeptide

# Metabolic_Enzyme_33_Synonyms:
RPB3; RNA polymerase II subunit 3; RPB33; RPB31

# Metabolic_Enzyme_33_Gene_Name:
POLR2C

# Metabolic_Enzyme_33_Protein_Sequence:
>DNAdirected RNA polymerase II 33 kDa polypeptide
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLISDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPNDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

# Metabolic_Enzyme_33_Number_of_Residues:
275

# Metabolic_Enzyme_33_Molecular_Weight:
31441

# Metabolic_Enzyme_33_Theoretical_pI:
4.54

# Metabolic_Enzyme_33_GO_Classification:
>>>
Function:  protein binding
Function:  protein dimerization activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Metabolic_Enzyme_33_General_Function:
Transcription 

# Metabolic_Enzyme_33_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

# Metabolic_Enzyme_33_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_33_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_33_Pfam_Domain_Function:
PF01000:RNA_pol_A_bac;
PF01193:RNA_pol_L

# Metabolic_Enzyme_33_Signals:
None

# Metabolic_Enzyme_33_Transmembrane_Regions:
None

# Metabolic_Enzyme_33_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_33_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_33_GenBank_ID_Protein:
337497

# Metabolic_Enzyme_33_SwissProt_ID:
RPB3_HUMAN (P19387)

# Metabolic_Enzyme_33_swissprot_Name:
Not Available

# Metabolic_Enzyme_33_Genecard_id:
POLR2C

# Metabolic_Enzyme_33_Geneatlas_id:
POLR2C

# Metabolic_Enzyme_33_hgnc_id:
HGNC:9189

# Metabolic_Enzyme_33_PDB_ID:
Not Available

# Metabolic_Enzyme_33_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_33_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_33_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_33_Gene_Sequence:
>828 bp
ATGCCGTACGCCAACCAGCCTACCGTGCGGATCACGGAGCTCACTGACGAGAATGTCAAG
TTCATCATCGAGAACACCGACCTGGCGGTGGCCAATTCGATTCGGAGGGTCTTCATCGCT
GAGGTTCCCATAATAGCCATTGACTGGGTTCAGATTGATGCCAATTCCTCAGTCCTTCAT
GATGAATTCATTGCTCACAGGCTTGGATTAATTCCCCTCATTAGTGATGACATTGTGGAC
AAGCTGCAGTACTCTCGGGACTGCACATGTGAGGAGTTCTGCCCCGAGTGCTCGGTGGAG
TTCACCCTCGATGTGCGGTGCAATGAAGACCAGACGCGACATGTCACGTCTCGAGACCTC
ATCTCCAACAGCCCCCGGGTCATTCCGGTGACATCCCGGAACCGAGATAATGACCCCAAT
GACTACGTGGAGCAGGATGACATCCTCATCGTCAAGTTGAGAAAGGGCCAGGAGCTGAGA
CTTCGAGCCTATGCCAAAAAGGGCTTTGGCAAGGAGCATGCCAAGTGGAACCCTACTGCA
GGGGTGGCTTTTGAATACGATCCAGACAATGCCCTGAGGACCACAGTGTACCCCAAGCCC
GAGGAATGGCCAAAGAGTGAGTACTCGGAGCTGGATGAGGATGAGTCGCAGGCTCCCTAT
GACCCCAACGGCAAGCCAGAAAGGTTTTACTACAATGTGGAGTCCTGTGGCTCTCTGCGT
CCTGAAACCATTGTCCTGTCAGCCCTCTCAGGATTGAAGAAGAAACTGAGTGATTTACAA
ACTCAATTAAGCCACGAGATCCAGAGTGATGTGCTAACCATAAATTAA

# Metabolic_Enzyme_33_GenBank_ID_Gene:
J05448

# Metabolic_Enzyme_33_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_33_Locus:
16q13-q21

# Metabolic_Enzyme_33_SNPs:
rs4937; rs170365; rs223838; rs601194; rs223839; rs4784809; rs223874; rs2161647; rs223837; rs2308250; rs2239355; rs1114157; rs178601; rs28362632; rs28362633; rs34299137; rs3831622; rs35150173; rs1080748; rs36102715; rs34798789; rs34335225; rs34001772; rs1114156; rs1080747; rs35407543; rs12919113; rs35175938; rs35747009; rs1043231; rs11867042; rs13336466; rs16957139; rs16957142; rs172782; rs1790650; rs183421; rs184401; rs2074545; rs223865; rs223866; rs223867; rs223868; rs223869; rs223870; rs223875; rs223876; rs223877; rs3177052; rs3785335; rs3859049; rs4784810; rs496772; rs523916; rs569425; rs598486; rs623685; rs625784; rs686402; rs739813

# Metabolic_Enzyme_33_General_References:
2187864; 9540830; 10493829

# Metabolic_Enzyme_33_References:
Not Available

# Metabolic_Enzyme_34_ID:
6030

# Metabolic_Enzyme_34_Name:
Choline-phosphate cytidylyltransferase A

# Metabolic_Enzyme_34_Synonyms:
Phosphorylcholine transferase A; CTP:phosphocholine cytidylyltransferase A; CT A; CCT A; CCT-alpha

# Metabolic_Enzyme_34_Gene_Name:
PCYT1A

# Metabolic_Enzyme_34_Protein_Sequence:
>Cholinephosphate cytidylyltransferase 
AMDAQCSAKVNARKRRKEAPGPNGATEEDGVPSKVQRCAVGLRQPAPFSDEIEVDFSKPY
VRVTMEEASRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTH
NFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSD
DVYKHIKEAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKK
YHLQERVDKVKEKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGAL
KHMLKEGKGRMLQAISPKQSPSSSPTRERSPSPSFRWPFSGKTSPPCSPANLSRHKAAAY
DISEDEED

# Metabolic_Enzyme_34_Number_of_Residues:
367

# Metabolic_Enzyme_34_Molecular_Weight:
41732

# Metabolic_Enzyme_34_Theoretical_pI:
6.85

# Metabolic_Enzyme_34_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_34_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_34_Specific_Function:
Controls phosphatidylcholine synthesis

# Metabolic_Enzyme_34_Pathway:
map00440  Aminophosphonate metabolism;
 map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_34_Reaction:
CTP + choline phosphate = diphosphate + CDP-choline

# Metabolic_Enzyme_34_Pfam_Domain_Function:
PF01467:CTP_transf_2

# Metabolic_Enzyme_34_Signals:
None

# Metabolic_Enzyme_34_Transmembrane_Regions:
None

# Metabolic_Enzyme_34_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_34_EC_Link:
EC 2.7.7.15

# Metabolic_Enzyme_34_GenBank_ID_Protein:
575486

# Metabolic_Enzyme_34_SwissProt_ID:
PCY1A_HUMAN (P49585)

# Metabolic_Enzyme_34_swissprot_Name:
Not Available

# Metabolic_Enzyme_34_Genecard_id:
PCYT1A

# Metabolic_Enzyme_34_Geneatlas_id:
PCYT1A

# Metabolic_Enzyme_34_hgnc_id:
HGNC:8754

# Metabolic_Enzyme_34_PDB_ID:
Not Available

# Metabolic_Enzyme_34_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_34_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_34_Subcellular_Location:
Cytoplasm; cytosol. Membrane; peripheral membrane protein (By similarity). Note=It can interconvert between an inactive cytosolic form and an active membrane-bound form (By similarity)

# Metabolic_Enzyme_34_Gene_Sequence:
>1104 bp
ATGGATGCACAGTGTTCAGCCAAGGTCAATGCAAGGAAGAGGAGAAAAGAGGCGCCCGGA
CCCAACGGGGCAACAGAAGAAGATGGGGTTCCTTCCAAAGTGCAGCGCTGTGCAGTGGGC
TTACGGCAACCAGCTCCTTTTTCTGATGAAATTGAAGTTGACTTTAGTAAGCCCTATGTC
AGGGTAACTATGGAAGAAGCCAGCAGAGGAACTCCTTGTGAGCGACCTGTGAGAGTTTAT
GCCGATGGAATATTTGACTTATTTCACTCTGGTCACGCCCGAGCTCTGATGCAAGCGAAG
AACCTTTTCCCTAATACGTACCTCATTGTGGGAGTTTGCAGTGATGAGCTCACACACAAC
TTCAAAGGCTTCACGGTGATGAACGAGAATGAGCGCTATGACGCAGTCCAGCACTGCCGC
TACGTGGATGAGGTGGTGAGGAATGCGCCCTGGACGCTGACACCCGAGTTCCTGGCCGAA
CACCGGATTGATTTTGTAGCCCATGATGATATTCCTTATTCATCTGCTGGCAGTGATGAT
GTTTATAAGCACATCAAGGAGGCAGGCATGTTTGCTCCAACACAGAGGACAGAAGGTATC
TCCACATCAGACATCATCACCCGAATTGTGCGGGATTATGATGTGTATGCGAGGCGGAAC
CTGCAGAGGGGCTACACAGCAAAGGAGCTCAATGTCAGCTTTATCAACGAGAAGAAATAC
CACTTGCAGGAGAGGGTTGACAAAGTAAAGGAGAAAGTGAAAGATGTGGAGGAAAAGTCA
AAAGAATTTGTTCAGAAGGTGGAGGAAAAAAGCATTGACCTCATTCAGAAGTGGGAGGAG
AAGTCCCGAGAATTCATTGGAAGTTTTCTGGAAATGTTTGGTCCGGAAGGAGCACTGAAA
CATATGCTGAAAGAGGGGAAGGGCCGGATGCTGCAGGCCATCAGCCCGAAGCAGAGCCCC
AGCAGCAGCCCTACTCGCGAGCGCTCCCCCTCCCCCTCTTTCCGATGGCCCTTCTCCGGC
AAGACTTCCCCACCTTGCTCCCCAGCAAATCTCTCCAGGCACAAGGCTGCAGCCTATGAT
ATCAGTGAGGATGAAGAAGACTAA

# Metabolic_Enzyme_34_GenBank_ID_Gene:
L28957

# Metabolic_Enzyme_34_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_34_Locus:
3q29

# Metabolic_Enzyme_34_SNPs:
rs12637288; rs3772109; rs3087896; rs3772108; rs2173600; rs2088666; rs6766480; rs12629949; rs12632779; rs7640304; rs2047551; rs4916421; rs7617236; rs17129026; rs11925711; rs7636149; rs6809764; rs1580820; rs7639752; rs12632013; rs1045075; rs12630070; rs9325436; rs12634587; rs2280525; rs1948690; rs9827027; rs6786041; rs12490786; rs12635925; rs12634304; rs7648600; rs7631992; rs1357289; rs939883; rs712012; rs884534; rs2342309; rs7616433; rs6583298; rs3201335; rs1317196; rs1806777; rs11921543; rs7616515; rs884535; rs12635069; rs3184886; rs3836216; rs13098269; rs13059928; rs34486577; rs34602349; rs34373615; rs769600; rs769603; rs2686643; rs11328923; rs35055188; rs2649740; rs10713731; rs10557420; rs34788840; rs13059909; rs12163633; rs13062089; rs4916456; rs36024007; rs12488019; rs7635355; rs796356; rs12487605; rs7615439; rs35065050; rs9837250; rs34616050; rs34103104; rs9714228; rs9713073; rs35854110; rs6795511; rs12631521; rs4396926; rs12053980; rs34715576; rs7623531; rs9714038; rs34225883; rs9713212; rs13068013; rs3772107; rs36084224; rs35261982; rs7610411; rs13079910; rs10668425; rs12494899; rs12494157; rs11716964; rs7641647; rs2936706; rs34514926; rs7632985; rs36042491; rs11709813; rs9713064; rs34171934; rs11185520; rs13097032; rs769602; rs1054928; rs769601; rs13099351; rs1357290; rs35182510; rs34451764; rs11332281; rs1044988; rs1045029; rs1052845; rs11185519; rs12491227; rs12638322; rs1476331; rs17852687; rs1875088; rs2293160; rs6778879; rs6793156; rs7631913; rs7638797; rs870339; rs9343; rs939884; rs939885; rs9849888

# Metabolic_Enzyme_34_General_References:
7918629; 8810902

# Metabolic_Enzyme_34_References:
Not Available

# Metabolic_Enzyme_35_ID:
6031

# Metabolic_Enzyme_35_Name:
DNA-directed RNA polymerase I-associated factor 53 kDa subunit

# Metabolic_Enzyme_35_Synonyms:
RNA polymerase I polypeptide E; RNA polymerase I- associated factor 1

# Metabolic_Enzyme_35_Gene_Name:
POLR1E

# Metabolic_Enzyme_35_Protein_Sequence:
>DNAdirected RNA polymerase Iassociated factor 53 kDa subunit
MYQASAVSLLPRDIPSCHSPSPGFSHLPTSSSQLAPDLLQFPLGQDPSFLAIPILTLPPS
DSLVPPYIVWYIVWPSALISFLGCTLTVQFSNGKLQSPGNMRFTLYENKDSTNPRKRNQR
ILAAETDRLSYVGNNFGTGALKCNTLCRHFVGILNKTSGQMEVYDAELFNMQPLFSDVSV
ESELALESQTKTYREKMDSCIEAFGTTKQKRALNTRRMNRVGNESLNRAVAKAAETIIDT
KGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNV
TSEEILKMIEENSHCTFVIEALKSLPSDVESRDRQARCIWFLDTLIKFRAHRVVKRKSAL
GPGVPHIINTKLLKHFTCLTYNNGRLRNLISDSMKAKITAYVIILALHIHDFQIDLTVLQ
RDLKLSEKRMMEIAKAMRLKISKRRVSVAAGSEEDHKLGTLSLPLPPAQTSDRLAKRRKI
T

# Metabolic_Enzyme_35_Number_of_Residues:
481

# Metabolic_Enzyme_35_Molecular_Weight:
53963

# Metabolic_Enzyme_35_Theoretical_pI:
8.74

# Metabolic_Enzyme_35_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Metabolic_Enzyme_35_General_Function:
Not Available

# Metabolic_Enzyme_35_Specific_Function:
Required for the initiation of transcription by the DNA- dependent RNA polymerase I holoenzyme. This complex catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

# Metabolic_Enzyme_35_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_35_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_35_Pfam_Domain_Function:
PF06870:RNA_pol_I_A49

# Metabolic_Enzyme_35_Signals:
None

# Metabolic_Enzyme_35_Transmembrane_Regions:
None

# Metabolic_Enzyme_35_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_35_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_35_GenBank_ID_Protein:
10435392

# Metabolic_Enzyme_35_SwissProt_ID:
RPF53_HUMAN (Q9GZS1)

# Metabolic_Enzyme_35_swissprot_Name:
Not Available

# Metabolic_Enzyme_35_Genecard_id:
POLR1E

# Metabolic_Enzyme_35_Geneatlas_id:
POLR1E

# Metabolic_Enzyme_35_hgnc_id:
HGNC:17631

# Metabolic_Enzyme_35_PDB_ID:
Not Available

# Metabolic_Enzyme_35_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_35_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_35_Subcellular_Location:
Nucleus; nucleolus

# Metabolic_Enzyme_35_Gene_Sequence:
>1260 bp
ATGGCGGCGGAGGTGTTGCCGAGTGCGAGGTGGCAGTATTGTGGGGCGCCCGACGGGAGC
CAGAGAGCTGTACTGGTCCAGTTCTCCAACGGGAAGCTACAGAGTCCAGGCAACATGCGC
TTTACCTTGTATGAGAACAAAGATTCCACCAACCCCAGGAAGAGGAATCAACGGATCCTG
GCAGCTGAAACAGATAGGCTCTCCTATGTGGGAAACAATTTTGGGACTGGAGCCCTCAAA
TGCAACACTTTGTGCAGGCACTTTGTGGGAATTTTGAACAAGACCTCTGGCCAAATGGAA
GTATATGATGCTGAATTGTTCAACATGCAGCCACTATTTTCAGATGTATCAGTTGAGAGT
GAACTGGCGCTAGAGAGTCAGACCAAAACTTACAGAGAAAAGATGGATTCTTGTATTGAA
GCCTTTGGTACCACCAAACAGAAGCGAGCTCTGAACACCAGGAGAATGAACAGAGTTGGC
AATGAATCTTTGAATCGTGCAGTGGCTAAAGCTGCAGAGACTATCATTGATACGAAGGGT
GTGACTGCTCTGGTCAGCGATGCTATCCACAATGACTTGCAAGATGACTCCCTCTACCTT
CCTCCCTGCTATGATGATGCAGCCAAGCCTGAAGACGTGTATAAATTTGAAGATCTTCTT
TCCCCTGCGGAGTATGAAGCTCTTCAGAGCCCATCTGAAGCTTTCAGGAACGTCACGTCA
GAAGAAATACTGAAGATGATTGAGGAGAACAGCCATTGCACCTTTGTCATAGAAGCGTTG
AAGTCTTTGCCATCAGATGTGGAGAGCCGAGACCGCCAGGCCCGATGCATATGGTTTCTG
GATACCCTCATCAAATTTCGAGCTCATAGGGTAGTTAAGCGGAAAAGTGCTCTGGGACCT
GGAGTTCCCCACATCATCAACACCAAACTGCTGAAGCACTTTACTTGCTTGACCTACAAC
AATGGCAGATTACGGAACTTAATTTCGGATTCTATGAAGGCGAAGATTACTGCATATGTG
ATCATACTTGCCTTGCACATACATGACTTCCAAATTGACCTGACAGTGTTACAGAGGGAC
TTGAAGCTCAGTGAGAAAAGGATGATGGAGATAGCCAAAGCCATGAGGCTGAAGATCTCC
AAAAGAAGGGTGTCTGTGGCCGCCGGCAGTGAAGAAGATCACAAACTGGGCACCCTGTCC
CTCCCGCTGCCTCCAGCCCAGACCTCAGACCGCCTGGCAAAGCGGAGGAAGATTACCTAG


# Metabolic_Enzyme_35_GenBank_ID_Gene:
AK023452

# Metabolic_Enzyme_35_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_35_Locus:
9p13.2

# Metabolic_Enzyme_35_SNPs:
rs7867180; rs7863488; rs16934203; rs10814571; rs2277161; rs17412622; rs10758434; rs16934141; rs16934158; rs3739576; rs11792930; rs913278; rs753968; rs754951; rs2274479; rs2274481; rs7860245; rs10814555; rs1887455; rs10814563; rs10814557; rs7863725; rs10814565; rs6476635; rs10758432; rs10814560; rs10814564; rs10814556; rs754950; rs2296775; rs10814568; rs10814551; rs10758433; rs7860865; rs7045170; rs10814549; rs10733487; rs7848968; rs10814554; rs2296778; rs7045332; rs7863996; rs2296776; rs10973374; rs3758223; rs10814566; rs4878694; rs3739575; rs10973369; rs10814567; rs16934150; rs10973361; rs10973367; rs2274480; rs12004135; rs10814544; rs7035434; rs3739573; rs7867542; rs2296777; rs2296774; rs1571234; rs7866535; rs3739574; rs10814561; rs10814562; rs10973371; rs10973383; rs10973380; rs7047330; rs7850736; rs10814558; rs10814570; rs753969; rs12115425; rs3758226; rs10814559; rs16934178; rs10973372; rs7044424; rs10814552; rs10973365; rs10814545; rs17411847; rs16934152; rs12378594; rs731993; rs10814569; rs7860878; rs3758225; rs10973375; rs7865901; rs16934189; rs7022491; rs10814550; rs10814547; rs10973378; rs12004935; rs7867123; rs10973373; rs10814553; rs10973360; rs11788293; rs10973368; rs34558553; rs7047823; rs1128859; rs1128853; rs7847322; rs10973366; rs12115427; rs35689166; rs10973363; rs10119071; rs7850367; rs33946064; rs10973384; rs11416451; rs33929501; rs3215845; rs3758224; rs35743467; rs4345649; rs11408322; rs10973379; rs41313768; rs10973382; rs41305323; rs10973377; rs35895363; rs10973364; rs35459704; rs12377791; rs10973362; rs35148517; rs7851078; rs10973376; rs10973381; rs7850492; rs34112340; rs34529274; rs10973358; rs12341731; rs4618788; rs4618787; rs17553670; rs10973359; rs35739898; rs34001879; rs12346017; rs10114371; rs10115300; rs10758435; rs10814542; rs10814573; rs10814574; rs10973353; rs10973387; rs1128206; rs11794762; rs11999016; rs12237351; rs4878153; rs4878695; rs7019936; rs7030940; rs7034104; rs7034254; rs7034391; rs7034585; rs730283; rs913279; rs913280; rs913281; rs913282

# Metabolic_Enzyme_35_General_References:
12429849

# Metabolic_Enzyme_35_References:
Not Available

# Metabolic_Enzyme_36_ID:
6032

# Metabolic_Enzyme_36_Name:
DNA-directed RNA polymerase III subunit C

# Metabolic_Enzyme_36_Synonyms:
DNA-directed III 62 kDa polypeptide; RNA polymerase III C62 subunit; RPC3

# Metabolic_Enzyme_36_Gene_Name:
POLR3C

# Metabolic_Enzyme_36_Protein_Sequence:
>DNAdirected RNA polymerase III subunit 
CMTQAEIKLCSLLLQEHFGEIVEKIGVHLIRTGSQPLRVIAHDTGTSLDQVKKALCVLVQ
HNLVSYQVHKRGVVEYEAQCSRVLRMLRYPRYIYTTKTLYSDTGELIVEELLLNGKLTMS
AVVKKVADRLTETMEDGKTMDYAEVSNTFVRLADTHFVQRCPSVPTTENSDPGPPPPAPT
LVINEKDMYLVPKLSLIGKGKRRRSSDEDAAGEPKAKRPKYTTDNKEPIPDDGIYWQANL
DRFHQHFRDQAIVSAVANRMDQTSSEIVRTMLRMSEITTSSSAPFTQPLSSNEIFRSLPV
GYNISKQVLDQYLTLLADDPLEFVGKSGDSGGGMYVINLHKALASLATATLESVVQERFG
SRCARIFRLVLQKKHIEQKQVEDFAMIPAKEAKDMLYKMLSENFMSLQEIPKTPDHAPSR
TFYLYTVNILSAARMLLHRCYKSIANLIERRQFETKENKRLLEKSQRVEAIIASMQATGA
EEAQLQEIEEMITAPERQQLETLKRNVNKLDASEIQVDETIFLLESYIECTMKRQ

# Metabolic_Enzyme_36_Number_of_Residues:
534

# Metabolic_Enzyme_36_Molecular_Weight:
60612

# Metabolic_Enzyme_36_Theoretical_pI:
7.34

# Metabolic_Enzyme_36_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_36_General_Function:
Not Available

# Metabolic_Enzyme_36_Specific_Function:
May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation

# Metabolic_Enzyme_36_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_36_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_36_Pfam_Domain_Function:
PF08221:HTH_9;
PF05645:RNA_pol_Rpc82

# Metabolic_Enzyme_36_Signals:
None

# Metabolic_Enzyme_36_Transmembrane_Regions:
None

# Metabolic_Enzyme_36_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_36_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_36_GenBank_ID_Protein:
2228748

# Metabolic_Enzyme_36_SwissProt_ID:
RPO3C_HUMAN (Q9BUI4)

# Metabolic_Enzyme_36_swissprot_Name:
Not Available

# Metabolic_Enzyme_36_Genecard_id:
POLR3C

# Metabolic_Enzyme_36_Geneatlas_id:
POLR3C

# Metabolic_Enzyme_36_hgnc_id:
HGNC:30076

# Metabolic_Enzyme_36_PDB_ID:
Not Available

# Metabolic_Enzyme_36_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_36_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_36_Subcellular_Location:
Nucleus (Potential)

# Metabolic_Enzyme_36_Gene_Sequence:
>1602 bp
ATGACTCAAGCAGAAATTAAGCTCTGTTCTTTGTTGCTGCAAGAGCATTTTGGAGAGATT
GTAGAAAAAATTGGAGTCCATCTGATAAGAACCGGCAGCCAGCCACTAAGAGTAATTGCC
CATGACACAGGAACATCACTGGATCAGGTGAAGAAAGCCCTGTGTGTCCTCGTCCAACAT
AACCTGGTGAGTTATCAAGTGCACAAACGTGGTGTGGTGGAGTATGAAGCCCAGTGCAGC
CGGGTATTGCGAATCGTTAGATATCCCCGGTACATCTATACTACCAAAACTCTGTACAGT
GACACTGGAGAGCTGATTGTTGAGGAGCTTCTGTTGAACGGCAAACTGACAATGTGCACT
GTTGTGAAGAAAGTGGCAGACCGGCTCACAGAGACCATGGAGGATGGCAAGACCATGGAC
TATNCTGAAGTATCAAACACATTTNTNCGACTGGCAGACACACACTTTGTACAACNNNNC
CCTTCGGTACCTACCACTGAGAATTCAGACCCTGGGCCACCACCACCTGCNCCCACACTT
GTCATTAATGAAAAGGACATGTACCTGGTTCCTAAACTCAGCTTGATAGGGAAAGGTAAA
AGGAGGAGATCATCTGATGAAGATGCTGCTGGGGAGCCCAAGGCAAGAGACCAAAATATA
CTACAGATAACAAGGNGCCCATTCCAGATGATGGGATTTATTGGCAGGCCCAACCTTGAC
AGATTCCGCCAACACTTCCGTGACCAAGCCATTGTGAGCGCAGTTGCTAACAGGATGGAC
CAGACAAGCAGCGAGATTGTGCGAACCATGCTCCGAATGAGTGAGATTACCACTTCCTCT
AGTGCTCCCTTCACCCAGCCATTGTTTTCCAATGAGATCTTCAGATCCCTACCTGTTGGC
TATAACATCTCTAAGCAAGTTCTTGATCAGTATCTCACTCTGCTGGCAGATGATCCACTA
GAGTTTGTTGGAAAGTCTGGCGACAGTGGTGGAGGAATGTATGTCATCAACCTCCATAAG
GCATTACGATCCCTAGCCACAGCCACTCTGGAGTCCGTCGTACAGGAGAGATTTGGGTCT
CGCTGTGCTAGAATATGCCGTCTAGTTTTGCAGAAGAAACACATAGAGCAGAAGCAAGTG
GAAGACTTTGCAATGATTCTGCAAGAGGCAAAGGATATGCTATATAAGATGCTCTCAGGA
AATTTCATGTCACTCCAGGAAATTCCCAAAACACCAGACCATGCCCCATCCAGGACCTTC
TATTTATATACTGTGAACATCCTGTCAGCTGCCCGAATGTTGTTCGACAGGTGCTACAAG
AGCATAGCCAACTTGATAGAAAGGAGGCAATTTGAAACCAAAGAGAATAAGCGTCTACTA
GAAAAATCTCAGAGGGTAGAAGCCATCATTGCATCTATGCAGGCTACTGGTGCAGAGGAA
GCACAGTTACAAGAAATAGAGGAGATGATCACAGCTCCTGAACGTCAGCAGCTAGAGACC
CTGAAACGTAATGTCAACAAGTTGGATGCCAGTGAGATCCAGGTGGNNGAAACCATCTTC
CTGCTGGAGTCTTACATTGAGTGCACCATGAAGAGACAGTGA

# Metabolic_Enzyme_36_GenBank_ID_Gene:
U93867

# Metabolic_Enzyme_36_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_36_Locus:
1q21.1

# Metabolic_Enzyme_36_SNPs:
rs4970859; rs9728345; rs2018027; rs10752826; rs11587821; rs4271151; rs9727157; rs3923471; rs9286837; rs16827080; rs1887806; rs913513; rs12143555; rs11589437; rs10752827; rs9728311; rs9729715; rs1536746; rs12044166; rs9729027; rs1804851; rs1044697; rs35933200; rs17849852; rs35893541; rs3754342; rs35821648; rs34387925; rs36107432; rs2018038; rs35497599; rs12143699; rs35129534; rs35376292; rs34635911; rs34968890; rs9662861; rs12059384; rs12139260; rs9701732; rs9700660; rs12145234; rs11319703; rs34369841; rs9729355; rs34316256; rs11370032; rs10528914; rs10564953; rs10524479; rs10590228; rs35865567; rs9729356; rs1050057; rs10910829; rs10910830; rs1328581; rs15446; rs16827062; rs16827075; rs17354559; rs1887802; rs1887803; rs1887804; rs1983954; rs2004659; rs4128488; rs9286836; rs9725551; rs9726019; rs9728498

# Metabolic_Enzyme_36_General_References:
9171375; 12384934; 10523658

# Metabolic_Enzyme_36_References:
Not Available

# Metabolic_Enzyme_37_ID:
6033

# Metabolic_Enzyme_37_Name:
6-phosphofructokinase, liver type

# Metabolic_Enzyme_37_Synonyms:
Phosphofructokinase 1; Phosphohexokinase; Phosphofructo-1-kinase isozyme B; PFK-B

# Metabolic_Enzyme_37_Gene_Name:
PFKL

# Metabolic_Enzyme_37_Protein_Sequence:
>6phosphofructokinase, liver type
MAAVDLEKLRASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVE
GGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDG
SLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDS
ALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWE
NFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQ
RGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQK
AMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRS
AVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESI
VENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLG
SDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFN
IHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGH
LQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFS
PVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQYRISMAAYVSGELEHVTRRTLSMDKGF


# Metabolic_Enzyme_37_Number_of_Residues:
780

# Metabolic_Enzyme_37_Molecular_Weight:
85020

# Metabolic_Enzyme_37_Theoretical_pI:
7.54

# Metabolic_Enzyme_37_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  phosphofructokinase activity
Function:  6-phosphofructokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  protein complex
Component:  6-phosphofructokinase complex
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_37_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_37_Specific_Function:
ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

# Metabolic_Enzyme_37_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00030  Pentose phosphate pathway;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism

# Metabolic_Enzyme_37_Reaction:
ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate

# Metabolic_Enzyme_37_Pfam_Domain_Function:
PF00365:PFK

# Metabolic_Enzyme_37_Signals:
None

# Metabolic_Enzyme_37_Transmembrane_Regions:
None

# Metabolic_Enzyme_37_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_37_EC_Link:
EC 2.7.1.11

# Metabolic_Enzyme_37_GenBank_ID_Protein:
35431

# Metabolic_Enzyme_37_SwissProt_ID:
K6PL_HUMAN (P17858)

# Metabolic_Enzyme_37_swissprot_Name:
Not Available

# Metabolic_Enzyme_37_Genecard_id:
PFKL

# Metabolic_Enzyme_37_Geneatlas_id:
PFKL

# Metabolic_Enzyme_37_hgnc_id:
HGNC:8876

# Metabolic_Enzyme_37_PDB_ID:
Not Available

# Metabolic_Enzyme_37_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_37_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_37_Subcellular_Location:
Not Available

# Metabolic_Enzyme_37_Gene_Sequence:
>2343 bp
ATGGCCGCGGTGGACCTGGAGAAGCTGCGGGCGTCGGGCGCGGGCAAGGCCATCGGCGTC
CTGACCAGCGGCGGCGACCGGCAAGGCATGAACGCTGCTGTCCGGGCTGTGACGCGCATG
GGCATTTATGTGGGTGCCAAAGTCTTCCTCATCTACGAGGGCTATGAGGGCCTCGTGGAG
GGAGGTGAGAACATCAAGCAGGCCAACTGGCTGAGCGTCTCCAACATCATCCAGCTGGGC
GGCACTATCATTGGCAGCGCTCGCTCGAAGGCCTTTACCACCAGGGAGGGGCGCCGGGCA
GCGGCCTACAACCTGGTCCAGCACGGCATCACCAACCTGTGCGTCATCGGCGGGGATGGC
AGCCTCACAGGTGCCAACATCTTCCGCAGCGAGTGGGGCAGCCTGCTGGAGGAGCTGGTG
GCGGAAGGTAAGATCTCAGAGACTACAGCCTGGACCTACTCGCACCTGAACATCGCGGGC
CTAGTGGGCTCCATCGATAACGACTTCTGCGGCACCGACATGACCATCGGCACGGACTCG
GCCCTCCACCGCATCATGGAGGTCATCGATGCCATCACCACCACTGCCCAGAGCCACCAG
AGGACCTTCGTGCTGGAAGTGATGGGCCGGCACTGCGGGTACCTGGCGCTGGTATCTGCA
CTGGCCTCAGGGGCCGACTGGCTGTTCATCCCCGAGGCTCCACCCGAGGACGGCTGGGAG
AACTTCATGTGTGAGAGGCTGGGTGAGACTCGGAGCCGTGGGTCCCGACTGAACATCATC
ATCATCGCTGAGGGTGCCATTGACCGCAACGGGAAGCCCATCTCGTCCAGCTACGTGAAG
GACCTGGTGGTTCAGAGGCTGGGCTTCGACACCCGTGTAACTGTGCTGGGCCACGTGCAG
CGGGGAGGGACGCCCTCTGCCTTCGACCGGATCCTGAGCAGCAAGATGGGCATGGAGGCG
GTGATGGCGCTGCTGGAAGCCACGCCTGACACGCCGGCCTGCGTGGTCACCCTCTCGGGG
AACCAGTCAGTGCGGCTGCCCCTCATGGAGTGCGTGCAGATGACCAAGGAAGTGCAGAAA
GCCATGGATGACAAGAGGTTTGACGAGGCCACCCAGCTCCGTGGTGGGAGCTTCGAGAAC
AACTGGAACATTTACAAGCTCCTCACCCACCAGAAGCCCCCCAAGGAGAAGTCTAACTTC
TCCCTGGCCATCCTGAATGTGGGGGCCCCGGCGGCTGGCATGAATGCGGCCGTGCGCTCG
GCGGTGCGGACCGGCATCTCCCATGGACACACAGTATACGTGGTGCACGATGGCTTCGAA
GGCCTAGCCAAGGGTCAGGTGCAAGAAGTAGGCTGGCACGACGTGGCCGGCTGGTTGGGG
CGTGGTGGCTCCATGCTGGGGACCAAGAGGACCCTGCCCAAGGGCCAGCTGGAGTCCATT
GTGGAGAACATCCGCATCTATGGTATTCACGCCCTGCTGGTGGTCGGTGGGTTTGAGGCC
TATGAAGGGGTGCTGCAGCTGGTGGAGGCTCGCGGGCGCTACGAGGAGCTCTGCATCGTC
ATGTGTGTCATCCCAGCCACCATCAGCAACAACGTCCCTGGCACCGACTTCAGCCTGGGC
TCCGACACTGCTGTAAATGCCGCCATGGAGAGCTGTGACCGCATCAAACAGTCTGCCTCG
GGGACCAAGCGCCGTGTGTTCATCGTGGAGACCATGGGGGGTTACTGTGGCTACCTGGCC
ACCGTGACTGGCATTGCTGTGGGGGCCGACGCCGCCTACGTCTTCGAGGACCCTTTCAAC
ATCCACGACTTAAAGGTCAACGTGGAGCACATGACGGAGAAGATGAAGACAGACATTCAG
AGGGGCCTGGTGCTGCGGAACGAGAAGTGCCATGACTACTACACCACGGAGTTCCTGTAC
AACCTGTACTCATCAGAGGGCAAGGGCGTCTTCGACTGCAGGACCAATGTCCTGGGCCAC
CTGCAGCAGGGTGGCGCTCCAACCCCCTTTGACCGGAACTATGGGACCAAGCTGGGGGTG
AAGGCCATGCTGTGGTTGTCGGAGAAGCTGCGCGAGGTTTACCGCAAGGGACGGGTGTTC
GCCAATGCCCCAGACTCGGCCTGCGTGATCGGCCTGAAGAAGAAGGCGGTGGCCTTCAGC
CCCGTCACTGAGCTCAAGAAAGACACTGATTTCGAGCACCGCATGCCACGGGAGCAGTGG
TGGCTGAGCCTGCGGCTCATGCTGAAGATGCTGGCACAATACCGCATCAGTATGGCCGCC
TACGTGTCAGGGGAGCTGGAGCACGTGACCCGCCGCACCCTGAGCATGGACAAGGGCTTC
TGA

# Metabolic_Enzyme_37_GenBank_ID_Gene:
X15573

# Metabolic_Enzyme_37_Chromosome_Location:
Not Available

# Metabolic_Enzyme_37_Locus:
Not Available

# Metabolic_Enzyme_37_SNPs:
rs1057037; rs9975113; rs1057034; rs2838545; rs2838544; rs2236669; rs3788115; rs8134520; rs7282369; rs8129937; rs4350841; rs3788116; rs7277792; rs2039274; rs9975994; rs1893208; rs2073436; rs2236670; rs9984426; rs7283094; rs3788117; rs3788114; rs9976073; rs9975988; rs9982262; rs9979367; rs9979369; rs9983978; rs2838550; rs2070568; rs8133730; rs3827256; rs2838549; rs2243542; rs7279267; rs2838548; rs2070569; rs2838547; rs11088947; rs2838546; rs2070571; rs928303; rs2250238; rs4818905; rs1972269; rs11909786; rs2277808; rs2776382; rs8127589; rs4818904; rs2070570; rs2276250; rs2847231; rs2876959; rs743484; rs12483184; rs2847229; rs743481; rs12483238; rs17004643; rs11908697; rs4818907; rs9977591; rs9981333; rs12482540; rs2276249; rs2276251; rs12482028; rs743483; rs2070567; rs9306096; rs2847230; rs1972267; rs9974877; rs2298692; rs1972268; rs9975413; rs4818906; rs10460741; rs9975207; rs11558848; rs11558850; rs17850433; rs17855402; rs9974772; rs9980790; rs11700493; rs34577649; rs1057222; rs3831402; rs35664594; rs2039275; rs1057197; rs8129860; rs9637179; rs8130111; rs11558849; rs35382076; rs34642010; rs9981255; rs34391295; rs34562056; rs35580361; rs34634869; rs3788120; rs34012756; rs743487; rs34319533; rs11269292; rs8133214; rs34875847; rs743486; rs9974934; rs35541329; rs35458462; rs743485; rs35890279; rs34330261; rs762425; rs3788118; rs12483015; rs34114410; rs17276063; rs9974264; rs13433407; rs743482; rs34915720; rs34644431; rs34835108; rs9975069; rs9306097; rs35213117; rs35820150; rs34193517; rs9975195; rs35158995; rs2741986; rs2741987; rs2850170; rs5844182; rs9975203; rs35045753; rs1003854; rs1056687; rs1056689; rs1056725; rs11552066; rs11552067; rs11911657; rs12627511; rs15145; rs1800521; rs1800522; rs1800524; rs1800525; rs1800526; rs2070573; rs2073610; rs2073611; rs2075877; rs2075878; rs2236441; rs2256817; rs2277809; rs2741985; rs2847225; rs3746965; rs3746966; rs3761392; rs3761393; rs3788113; rs4818709; rs4818710; rs760426; rs760427; rs933150; rs941405; rs9976610

# Metabolic_Enzyme_37_General_References:
2533063; 2139864; 10830953; 12665801

# Metabolic_Enzyme_37_References:
Not Available

# Metabolic_Enzyme_38_ID:
6034

# Metabolic_Enzyme_38_Name:
DNA-directed RNA polymerase I 40 kDa polypeptide

# Metabolic_Enzyme_38_Synonyms:
RPA40; RPA39

# Metabolic_Enzyme_38_Gene_Name:
POLR1C

# Metabolic_Enzyme_38_Protein_Sequence:
>DNAdirected RNA polymerase I 40 kDa polypeptide
MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENS
LEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPR
LFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGN
QADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDIT
LLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLA
RVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD

# Metabolic_Enzyme_38_Number_of_Residues:
346

# Metabolic_Enzyme_38_Molecular_Weight:
39250

# Metabolic_Enzyme_38_Theoretical_pI:
5.18

# Metabolic_Enzyme_38_GO_Classification:
>>>
Function:  protein binding
Function:  protein dimerization activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Metabolic_Enzyme_38_General_Function:
Transcription 

# Metabolic_Enzyme_38_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

# Metabolic_Enzyme_38_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_38_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_38_Pfam_Domain_Function:
PF01000:RNA_pol_A_bac;
PF01193:RNA_pol_L

# Metabolic_Enzyme_38_Signals:
None

# Metabolic_Enzyme_38_Transmembrane_Regions:
None

# Metabolic_Enzyme_38_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_38_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_38_GenBank_ID_Protein:
2266929

# Metabolic_Enzyme_38_SwissProt_ID:
RPA5_HUMAN (O15160)

# Metabolic_Enzyme_38_swissprot_Name:
Not Available

# Metabolic_Enzyme_38_Genecard_id:
POLR1C

# Metabolic_Enzyme_38_Geneatlas_id:
POLR1C

# Metabolic_Enzyme_38_hgnc_id:
HGNC:20194

# Metabolic_Enzyme_38_PDB_ID:
Not Available

# Metabolic_Enzyme_38_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_38_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_38_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_38_Gene_Sequence:
>1041 bp
ATGGCGGCTTCTCAGGCGGTGGAGGAAATGCGGAGCCGCGTGGTTCTGGGGGAGTTTGGG
GTTCGCAATGTCCATACTACTGACTTTCCCGGTAACTATTCCGGTTATGATGATGCCTGG
GACCAGGACCGCTTCGAGAAGAATTTCCGTGTGGATGTAGTACACATGGATGAAAACTCA
CTGGAGTTTGACATGGTGGGAATTGACGCAGCCATTGCCAATGCTTTTCGACGAATTCTG
CTAGCTGAGGTGCCAACTATGGCTGTGGAGAAGGTCCTGGTGTACAATAATACATCCATT
GTTCAGGATGAGATTCTTGCTCACCGTCTGGGGCTCATTCCCATTCATGCTGATCCCCGT
CTTTTTGAGTATCGGAACCAAGGAGATGAAGAAGGCACAGAGATAGATACTCTACAGTTT
CGTCTCCAGGTCAGATGCACTCGGAACCCCCATGCTGCTAAAGATTCCTCTGACCCCAAC
GAACTGTACGTGAACCACAAAGTGTATACCAGGCATATGACATGGATCCCCCTGGGGAAC
CAGGCTGATCTCTTTCCAGAGGGCACTATCCGACCAGTGCATGATGATATCCTCATCGCT
CAGCTGCGGCCTGGCCAAGAAATTGACCTGCTCATGCACTGTGTCAAGGGCATTGGCAAA
GATCATGCCAAGTTTTCACCAGTGGCAACAGCCAGTTACAGGCTCCTGCCAGACATCACC
CTGCTTGAGCCCGTGGAAGGGGAGGCAGCTGAGGAGTTGAGCAGGTGCTTCTCACCTGGT
GTTATTGAGGTGCAGGAAGTCCAAGGTAAAAAGGTGGCCAGAGTTGCCAACCCCCGGCTG
GATACCTTCAGCAGAGAAATCTTCCGGAATGAGAAGCTAAAGAAGGTTGTGAGGCTTGCC
CGGGTTCGAGATCATTATATCTTCTCTGTTGAGTCAACGGGGGTGTTGCCACCAGATGTG
CTGGTGAGTGAAGCCATCAAAGTACTGATGGGGAAGTGCCGGCGCTTCTTGGATGAACTA
GATGCGGTTCAGATGGACTGA

# Metabolic_Enzyme_38_GenBank_ID_Gene:
AF008442

# Metabolic_Enzyme_38_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_38_Locus:
6p21.1

# Metabolic_Enzyme_38_SNPs:
Not Available

# Metabolic_Enzyme_38_General_References:
9540830; 9653160; 14574404

# Metabolic_Enzyme_38_References:
Not Available

# Metabolic_Enzyme_39_ID:
6035

# Metabolic_Enzyme_39_Name:
DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide

# Metabolic_Enzyme_39_Synonyms:
RPC8

# Metabolic_Enzyme_39_Gene_Name:
POLR3H

# Metabolic_Enzyme_39_Protein_Sequence:
>DNAdirected RNA polymerase III subunit 22.9 kDa polypeptide
MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVF
PGDGASHTKVHFRCVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKF
DEAEQVWVWEYETEEGAHDLYMDTGEEIRFRVVDESFVDTSPTGPSSADATTSSEELPKK
EAPYTLVGSISEPGLGLLSWWTSN

# Metabolic_Enzyme_39_Number_of_Residues:
204

# Metabolic_Enzyme_39_Molecular_Weight:
22918

# Metabolic_Enzyme_39_Theoretical_pI:
4.21

# Metabolic_Enzyme_39_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_39_General_Function:
Transcription 

# Metabolic_Enzyme_39_Specific_Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

# Metabolic_Enzyme_39_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_39_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_39_Pfam_Domain_Function:
PF08292:RNA_pol_Rbc25;
PF03876:RNA_pol_Rpb7_N

# Metabolic_Enzyme_39_Signals:
None

# Metabolic_Enzyme_39_Transmembrane_Regions:
None

# Metabolic_Enzyme_39_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_39_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_39_GenBank_ID_Protein:
24429623

# Metabolic_Enzyme_39_SwissProt_ID:
RPC8_HUMAN (Q9Y535)

# Metabolic_Enzyme_39_swissprot_Name:
Not Available

# Metabolic_Enzyme_39_Genecard_id:
POLR3H

# Metabolic_Enzyme_39_Geneatlas_id:
POLR3H

# Metabolic_Enzyme_39_hgnc_id:
HGNC:30349

# Metabolic_Enzyme_39_PDB_ID:
Not Available

# Metabolic_Enzyme_39_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_39_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_39_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_39_Gene_Sequence:
>615 bp
ATGTTCGTCCTGGTGGAAATGGTGGACACCGTCCGGATCCCCCCTTGGCAGTTTGAGAGG
AAGCTCAACGACTCCATTGCCGAGGAGCTGAACAAGAAGTTGGCCAACAAGGTCGTGTAC
AACGTGGGACTCTGCATTTGTCTGTTTGATATCACCAAACTGGAGGATGCCTATGTATTC
CCTGGGGATGGCGCATCACACACCAAAGTCCATTTTCGCTGCGTGGTGTTTCATCCATTC
CTAGATGAGATTCTCATTGGGAAGATCAAAGGCTGCAGCCCAGAAGGAGTGCACGTCTCT
CTAGGCTTCTTCGATGACATTCTCATCCCCCCAGAGTCACTGCAGCAGCCAGCCAAGTTC
GACGAAGCGGAGCAGGTGTGGGTGTGGGAGTACGAGACGGAGGAAGGAGCACACGACCTC
TACATGGACACCGGCGAGGAGATCCGCTTCCGGGTGGTGGACGAGAGCTTTGTTGACACG
TCCCCCACAGGGCCCAGCTCAGCAGATGCCACCACTTCCAGTGAGGAGCTGCCAAAGAAG
GAGGCTCCGTACACGCTTGTGGGATCCATCAGTGAGCCAGGCCTGGGCCTTCTCTCCTGG
TGGACCAGCAACTAG

# Metabolic_Enzyme_39_GenBank_ID_Gene:
AY092087

# Metabolic_Enzyme_39_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_39_Locus:
22q13.2

# Metabolic_Enzyme_39_SNPs:
rs35463585; rs1810461; rs1810460; rs203313; rs4822032; rs482402; rs2076197; rs169407; rs12483991; rs5758384; rs12484228; rs4822033; rs4822035; rs2076198; rs9611606; rs5751123; rs4822036; rs4822034; rs12483998; rs5758386; rs12483786; rs9623414; rs5758389; rs11554329; rs28403300; rs11554328; rs11703078; rs203314; rs12159517; rs5758383; rs5751122; rs28469669; rs28660040; rs34232812; rs9607811; rs11703265; rs28530678; rs5758385; rs172150; rs28541706; rs34786259; rs35844646; rs9611608; rs9623415; rs9611607; rs175919; rs34510863; rs34737574; rs5751121; rs5751120; rs9607813; rs5758387; rs12167511; rs12330014; rs28623192; rs9607812; rs5758388; rs11090049; rs12484694; rs13057804; rs17367716; rs17367849; rs1960182; rs203311; rs203312; rs203315; rs203316; rs203317; rs203319; rs203320; rs34057431; rs35849502; rs4510317; rs4822037; rs5751124; rs5758381; rs6002400; rs8140591; rs9611604; rs9611610; rs9619974

# Metabolic_Enzyme_39_General_References:
12391170; 11258795; 10591208

# Metabolic_Enzyme_39_References:
Not Available

# Metabolic_Enzyme_40_ID:
6036

# Metabolic_Enzyme_40_Name:
DNA-directed RNA polymerases III 12.5 kDa polypeptide

# Metabolic_Enzyme_40_Synonyms:
RNA polymerase III subunit K; RNA polymerase III C11 subunit; HsC11p; hRPC11

# Metabolic_Enzyme_40_Gene_Name:
POLR3K

# Metabolic_Enzyme_40_Protein_Sequence:
>DNAdirected RNA polymerases III 12.5 kDa polypeptide
MLLFCPGCGNGLIVEEGQRCHRFSCNTCPYVHNITRKVTNRKYPKLKEVDDVLGGAAAWE
NVDSTAESCPKCEHPRAYFMQLQTRSADEPMTTFYKCCNAQCGHRWRD

# Metabolic_Enzyme_40_Number_of_Residues:
108

# Metabolic_Enzyme_40_Molecular_Weight:
12336

# Metabolic_Enzyme_40_Theoretical_pI:
7.89

# Metabolic_Enzyme_40_GO_Classification:
>>>
Function:  transcription factor activity
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed RNA polymerase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
Process:  transcription, DNA-dependent
Process:  RNA elongation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_40_General_Function:
Transcription 

# Metabolic_Enzyme_40_Specific_Function:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_40_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03020  RNA polymerase

# Metabolic_Enzyme_40_Reaction:
nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

# Metabolic_Enzyme_40_Pfam_Domain_Function:
PF02150:RNA_POL_M_15KD;
PF01096:TFIIS_C

# Metabolic_Enzyme_40_Signals:
None

# Metabolic_Enzyme_40_Transmembrane_Regions:
None

# Metabolic_Enzyme_40_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_40_EC_Link:
EC 2.7.7.6

# Metabolic_Enzyme_40_GenBank_ID_Protein:
4877775

# Metabolic_Enzyme_40_SwissProt_ID:
RPC11_HUMAN (Q9Y2Y1)

# Metabolic_Enzyme_40_swissprot_Name:
Not Available

# Metabolic_Enzyme_40_Genecard_id:
POLR3K

# Metabolic_Enzyme_40_Geneatlas_id:
POLR3K

# Metabolic_Enzyme_40_hgnc_id:
HGNC:14121

# Metabolic_Enzyme_40_PDB_ID:
Not Available

# Metabolic_Enzyme_40_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_40_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_40_Subcellular_Location:
Nucleus (Potential)

# Metabolic_Enzyme_40_Gene_Sequence:
>327 bp
ATGCTGCTGTTCTGCCCCGGCTGCGGGAACGGGCTGATCGTGGAGGAGGGACAACGCTGC
CACCGCTTCGCCTGCAACACGTGCCCCTACGTGCACAACATCACCCGCAAGGTAACAAAT
CGGAAGTACCCAAAACTGAAAGAAGTGGATGATGTGCTTGGTGGAGCAGCTGCCTGGGAG
AATGTTGACTCTACTGCAGAGTCGTGTCCCAAATGCGAACATCCTCGTGCTTACTTCATG
CAGCTTCAGACCCGCTCTGCAGATGAGCCGATGACCACCTTCTACAAGTGCTGCAATGCT
CAGTGTGGACACCGCTGGAGGGATTAG

# Metabolic_Enzyme_40_GenBank_ID_Gene:
AF126531

# Metabolic_Enzyme_40_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_40_Locus:
16p13.3

# Metabolic_Enzyme_40_SNPs:
rs8466; rs798675; rs7187013; rs216587; rs216589; rs8056400; rs12597930; rs798673; rs4984750; rs1804; rs11645557; rs11865899; rs12923892; rs11861402; rs216588; rs12933420; rs8051696; rs12933429; rs11864394; rs8058202; rs8062274; rs811633; rs35855841; rs35296795; rs36105812; rs798674; rs34071949; rs10266; rs1045001; rs11859712; rs11865293; rs13337364; rs170058; rs183360; rs216590; rs216595; rs216596; rs216597; rs216599; rs216600; rs216601; rs216603; rs2541593; rs2541594; rs2541696; rs2562145; rs2562146; rs2858042; rs3213509; rs3213510; rs3213511; rs34400346; rs35497622; rs743724; rs9926790

# Metabolic_Enzyme_40_General_References:
9869639; 10079944; 11157797

# Metabolic_Enzyme_40_References:
Not Available

# Metabolic_Enzyme_41_ID:
6037

# Metabolic_Enzyme_41_Name:
6-phosphofructokinase, muscle type

# Metabolic_Enzyme_41_Synonyms:
Phosphofructokinase 1; Phosphohexokinase; Phosphofructo-1-kinase isozyme A; PFK-A; Phosphofructokinase-M

# Metabolic_Enzyme_41_Gene_Name:
PFKM

# Metabolic_Enzyme_41_Protein_Sequence:
>6phosphofructokinase, muscle type
MTHEEHHAAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVD
GGDHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDG
SLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDS
ALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWE
EHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQ
RGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTK
AMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRPPVSKSGSHTVAVMNVGAPAAGMNAAVR
STVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQ
ISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSV
GADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPF
TIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLG
HMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVF
QPVAELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKRSGEAAV


# Metabolic_Enzyme_41_Number_of_Residues:
780

# Metabolic_Enzyme_41_Molecular_Weight:
85184

# Metabolic_Enzyme_41_Theoretical_pI:
8.07

# Metabolic_Enzyme_41_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  phosphofructokinase activity
Function:  6-phosphofructokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  protein complex
Component:  6-phosphofructokinase complex
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_41_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_41_Specific_Function:
ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

# Metabolic_Enzyme_41_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00030  Pentose phosphate pathway;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism

# Metabolic_Enzyme_41_Reaction:
ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate

# Metabolic_Enzyme_41_Pfam_Domain_Function:
PF00365:PFK

# Metabolic_Enzyme_41_Signals:
None

# Metabolic_Enzyme_41_Transmembrane_Regions:
None

# Metabolic_Enzyme_41_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_41_EC_Link:
EC 2.7.1.11

# Metabolic_Enzyme_41_GenBank_ID_Protein:
1101758

# Metabolic_Enzyme_41_SwissProt_ID:
K6PF_HUMAN (P08237)

# Metabolic_Enzyme_41_swissprot_Name:
Not Available

# Metabolic_Enzyme_41_Genecard_id:
PFKM

# Metabolic_Enzyme_41_Geneatlas_id:
PFKM

# Metabolic_Enzyme_41_hgnc_id:
HGNC:8877

# Metabolic_Enzyme_41_PDB_ID:
Not Available

# Metabolic_Enzyme_41_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_41_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_41_Subcellular_Location:
Not Available

# Metabolic_Enzyme_41_Gene_Sequence:
>2343 bp
ATGACCCATGAAGAGCACCATGCAGCCAAAACCCTGGGGATTGGCAAAGCCATTGCTGTC
TTAACCTCTGGTGGAGATGCCCAAGGTATGAATGCTGCTGTCAGGGCTGTGGTTCGAGTT
GGTATCTTCACCGGTGCCCGTGTCTTCTTTGTCCATGAGGGTTATCAAGGCCTGGTGGAT
GGTGGAGATCACATCAAGGAAGCCACCTGGGAGAGCGTTTCGATGATGCTTCAGCTGGGA
GGCACGGTGATTGGAAGTGCCCGGTGCAAGGACTTTCGGGAACGAGAAGGACGACTCCGA
GCTGCCTACAACCTGGTGAAGCGTGGGATCACCAATCTCTGTGTCATTGGGGGTGATGGC
AGCCTCACTGGGGCTGACACCTTCCGTTCTGAGTGGAGTGACTTGTTGAGTGACCTCCAG
AAAGCAGGTAAGATCACAGATGAGGAGGCTACGAAGTCCAGCTACCTGAACATTGTGGGC
CTGGTTGGGTCAATTGACAATGACTTCTGTGGCACTGATATGACCATTGGCACTGACTCT
GCCCTGCATCGGATCATGGAAATTGTAGATGCCATCACTACCACTGCCCAGAGCCACCAG
AGGACATTTGTGTTAGAAGTAATGGGCCGCCACTGTGGATACCTGGCCCTTGTCACCTCT
CTGTCCTGTGGGGCCGACTGGGTTTTTATTCCTGAATGTCCACCAGATGACGACTGGGAG
GAACACCTTTGTCGCCGACTCAGCGAGACAAGGACCCGTGGTTCTCGTCTCAACATCATC
ATTGTGGCTGAGGGTGCAATTGACAAGAATGGAAAACCAATCACCTCAGAAGACATCAAG
AATCTGGTGGTTAAGCGTCTGGGATATGACACCCGGGTTACTGTCTTGGGGCATGTGCAG
AGGGGTGGGACGCCATCAGCCTTTGACAGAATTCTGGGCAGCAGGATGGGTGTGGAAGCA
GTGATGGCACTTTTGGAGGGGACCCCAGATACCCCAGCCTGTGTAGTGAGCCTCTCTGGT
AACCAGGCTGTGCGCCTGCCCCTCATGGAATGTGTCCAGGTGACCAAAGATGTGACCAAG
GCCATGGATGAGAAGAAATTTGACGAAGCCCTGAAGCTGAGAGGCCGGAGCTTCATGAAC
AACTGGGAGGTGTACAAGCTTCTAGCTCATGTCAGACCCCCGGTATCTAAGAGTGGTTCG
CACACAGTGGCTGTGATGAACGTGGGGGCTCCGGCTGCAGGCATGAATGCTGCTGTTCGC
TCCACTGTGAGGATTGGCCTTATCCAGGGCAACCGAGTGCTCGTTGTCCATGATGGTTTC
GAGGGCCTGGCCAAGGGGCAGATAGAGGAAGCTGGCTGGAGCTATGTTGGGGGCTGGACT
GGCCAAGGTGGCTCTAAACTTGGGACTAAAAGGACTCTACCCAAGAAGAGCTTTGAACAG
ATCAGTGCCAATATAACTAAGTTTAACATTCAGGGCCTTGTCATCATTGGGGGCTTTGAG
GCTTACACAGGGGGCCTGGAACTGATGGAGGGCAGGAAGCAGTTTGATGAGCTCTGCATC
CCATTTGTGGTCATTCCTGCTACAGTCTCCAACAATGTCCCTGGCTCAGACTTCAGCGTT
GGGGCTGACACAGCACTCAATACTATCTGCACAACCTGTGACCGCATCAAGCAGTCAGCA
GCTGGCACCAAGCGTCGGGTGTTTATCATTGAGACTATGGGTGGCTACTGTGGCTACCTG
GCTACCATGGCTGGACTGGCAGCTGGGGCCGATGCTGCCTACATTTTTGAGGAGCCCTTC
ACCATTCGAGACCTGCAGGCAAATGTTGAACATCTGGTGCAAAAGATGAAAACAACTGTG
AAAAGGGGCTTGGTGTTAAGGAATGAAAAGTGCAATGAGAACTATACCACTGACTTCATT
TTCAACCTGTACTCTGAGGAGGGGAAGGGCATCTTCGACAGCAGGAAGAATGTGCTTGGT
CACATGCAGCAGGGTGGGAGCCCAACCCCATTTGATAGGAATTTTGCCACTAAGATGGGC
GCCAAGGCTATGAACTGGATGTCTGGGAAAATCAAAGAGAGTTACCGTAATGGGCGGATC
TTTGCCAATACTCCAGATTCGGGCTGTGTTCTGGGGATGCGTAAGAGGGCTCTGGTCTTC
CAACCAGTGGCTGAGCTGAAGGACCAGACAGATTTTGAGCATCGAATCCCCAAGGAACAG
TGGTGGCTGAAACTGAGGCCCATCCTCAAAATCCTAGCCAAGTACGAGATTGACTTGGAC
ACTTCAGACCATGCCCACCTGGAGCACATCACCCGGAAGCGGTCCGGGGAAGCTGCCGTC
TAA

# Metabolic_Enzyme_41_GenBank_ID_Gene:
M59741

# Metabolic_Enzyme_41_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_41_Locus:
12q13.3

# Metabolic_Enzyme_41_SNPs:
rs2228500; rs8716; rs1049392; rs1859445; rs1476607; rs4760685; rs4075913; rs2286020; rs4760684; rs10875747; rs2286021; rs11168421; rs10082861; rs4141065; rs2269933; rs10875749; rs10875746; rs12304251; rs10219645; rs11168424; rs11168423; rs7484648; rs10875748; rs11168427; rs11830546; rs11168425; rs10219623; rs11168419; rs4760683; rs10875745; rs11168417; rs2269935; rs11168418; rs11168420; rs11552506; rs41291965; rs12828446; rs41291971; rs12826853; rs12317430; rs41290390; rs11552507; rs14683; rs3189641; rs8977; rs35847394; rs11374838; rs34737106; rs12817932; rs41291969; rs12826678; rs34747961; rs34241029; rs36015571; rs3989535; rs11168422; rs11609979; rs12826680; rs34700912; rs33914383; rs7978674; rs41291963; rs7301375; rs12831427; rs41291961; rs41291967; rs34996435; rs34207745; rs4075914; rs35651820; rs11835145; rs7133146; rs10219520; rs10783230; rs10875750; rs11168413; rs11168414; rs11168428; rs11608670; rs12297470; rs12310813; rs12422786; rs12579815; rs1802781; rs3936179; rs4760682; rs4760686; rs7302354; rs7485355; rs7488265; rs8804

# Metabolic_Enzyme_41_General_References:
1833270; 2526045; 2822475; 2140567; 2526044; 7550225; 7513946; 7825568; 8889589

# Metabolic_Enzyme_41_References:
Not Available

# Metabolic_Enzyme_42_ID:
6039

# Metabolic_Enzyme_42_Name:
Pyruvate kinase isozymes M1/M2

# Metabolic_Enzyme_42_Synonyms:
Pyruvate kinase muscle isozyme; Pyruvate kinase 2/3; Cytosolic thyroid hormone-binding protein; CTHBP; THBP1

# Metabolic_Enzyme_42_Gene_Name:
PKM2

# Metabolic_Enzyme_42_Protein_Sequence:
>Pyruvate kinase isozymes M1/M2
MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEAS
FKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP

# Metabolic_Enzyme_42_Number_of_Residues:
531

# Metabolic_Enzyme_42_Molecular_Weight:
57938

# Metabolic_Enzyme_42_Theoretical_pI:
7.94

# Metabolic_Enzyme_42_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  pyruvate kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_42_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_42_Specific_Function:
ATP + pyruvate = ADP + phosphoenolpyruvate

# Metabolic_Enzyme_42_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00230  Purine metabolism;
 map00620  Pyruvate metabolism;
 map00710  Carbon fixation

# Metabolic_Enzyme_42_Reaction:
ATP + pyruvate = ADP + phosphoenolpyruvate

# Metabolic_Enzyme_42_Pfam_Domain_Function:
PF00224:PK;
PF02887:PK_C

# Metabolic_Enzyme_42_Signals:
None

# Metabolic_Enzyme_42_Transmembrane_Regions:
None

# Metabolic_Enzyme_42_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_42_EC_Link:
EC 2.7.1.40

# Metabolic_Enzyme_42_GenBank_ID_Protein:
189998

# Metabolic_Enzyme_42_SwissProt_ID:
KPYM_HUMAN (P14618)

# Metabolic_Enzyme_42_swissprot_Name:
Not Available

# Metabolic_Enzyme_42_Genecard_id:
PKM2

# Metabolic_Enzyme_42_Geneatlas_id:
PKM2

# Metabolic_Enzyme_42_hgnc_id:
HGNC:9021

# Metabolic_Enzyme_42_PDB_ID:
1F3X

# Metabolic_Enzyme_42_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_42_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_42_Subcellular_Location:
Not Available

# Metabolic_Enzyme_42_Gene_Sequence:
>1596 bp
ATGTCGAAGCCCCATAGTGAAGCCGGGACTGCCTTCATTCAGACCCAGCAGCTGCACGCA
GCCATGGCTGACACATTCCTGGAGCACATGTGCCGCCTGGACATTGATTCACCACCCATC
ACAGCCCGGAACACTGGCATCATCTGTACCATTGGCCCAGCTTCCCGATCAGTGGAGACG
TTGAAGGAGATGATTAAGTCTGGAATGAATGTGGCTCGTCTGAACTTCTCTCATGGAACT
CATGAGTACCATGCGGAGACCATCAAGAATGTGCGCACAGCCACGGAAAGCTTTGCTTCT
GACCCCATCCTCTACCGGCCCGTTGCTGTGGCTCTAGACACTAAAGGACCTGAGATCCGA
ACTGGGCTCATCAAGGGCAGCGGCACTGCAGAGGTGGAGCTGAAGAAGGGAGCCACTCTC
AAAATCACGCTGGATAACGCCTACATGGAAAAGTGTGACGAGAACATCCTGTGGCTGGAC
TACAAGAACATCTGCAAGGTGGTGGAAGTGGGCAGCAAGATCTACGTGGATGATGGGCTT
ATTTCTCTCCAGGTGAAGCAGAAAGGTGCCGACTTCCTGGTGACGGAGGTGGAAAATGGT
GGCTCCTTGGGCAGCAAGAAGGGTGTGAACCTTCCTGGGGCTGCTGTGGACTTGCCTGCT
GTGTCGGAGAAGGACATCCAGGATCTGAAGTTTGGGGTCGAGCAGGATGTTGATATGGTG
TTTGCGTCATTCATCCGCAAGGCATCTGATGTCCATGAAGTTAGGAAGGTCCTGGGAGAG
AAGGGAAAGAACATCAAGATTATCAGCAAAATCGAGAATCATGAGGGGGTTCGGAGGTTT
GATGAAATCCTGGAGGCCAGTGATGGGATCATGGTGGCTCGTGGTGATCTAGGCATTGAG
ATTCCTGCAGAGAAGGTCTTCCTTGCTCAGAAGATGATGATTGGACGGTGCAACCGAGCT
GGGAAGCCTGTCATCTGTGCTACTCAGATGCTGGAGAGCATGATCAAGAAGCCCCGCCCC
ACTCGGGCTGAAGGCAGTGATGTGGCCAATGCAGTCCTGGATGGAGCCGACTGCATCATG
CTGTCTGGAGAAACAGCCAAAGGGGACTATCCTCTGGAGGCTGTGCGCATGCAGAACCTG
ATTGCCCGTGAGGCAGAGGCTGCCATCTACCACTTGCAATTATTTGAGGAACTCCGCCGC
CTGGCGCCCATTACCAGCGACCCCACAGAAGCCACCGCCGTGGGTGCCGTGGAGGCCTCC
TTCAAGTGCTGCAGTGGGGCCATAATCGTCCTCACCAAGTCTGGCAGGTCTGCTCACCAG
GTGGCCAGATACCGCCCACGTGCCCCCATCATTGCTGTGACCCGGAATCCCCAGACAGCT
CGTCAGGCCCACCTGTACCGTGGCATCTTCCCTGTGCTGTGCAAGGACCCAGTCCAGGAG
GCCTGGGCTGAGGACGTGGACCTCCGGGTGAACTTTGCCATGAATGTTGGCAAGGCCCGA
GGCTTCTTCAAGAAGGGAGATGTGGTCATTGTGCTGACCGGATGGCGCCCTGGCTCCGGC
TTCACCAACACCATGCGTGTTGTTCCTGTGCCGTGA

# Metabolic_Enzyme_42_GenBank_ID_Gene:
M23725

# Metabolic_Enzyme_42_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_42_Locus:
15q22

# Metabolic_Enzyme_42_SNPs:
rs10514; rs3759901; rs1037680; rs890312; rs2052713; rs6494994; rs6494995; rs8192386; rs8192381; rs8192362; rs8192385; rs8192364; rs8192357; rs7179427; rs8192363; rs8192392; rs8192356; rs4611402; rs8192365; rs8192355; rs12441553; rs8192350; rs8192354; rs8192353; rs8192359; rs8192379; rs2959906; rs8192387; rs8192374; rs8192378; rs8192360; rs8192367; rs8192417; rs4506844; rs8033167; rs3825868; rs8192420; rs8192418; rs2607090; rs2856929; rs8192393; rs3825949; rs8040828; rs8031386; rs8192419; rs8192401; rs11631216; rs8192396; rs8192400; rs6494993; rs8192422; rs8192402; rs8192425; rs12591361; rs8192397; rs3803471; rs8023703; rs8192431; rs2959908; rs4777493; rs8192394; rs916133; rs8192413; rs8192399; rs12594297; rs8192404; rs8192412; rs8192395; rs8192408; rs8192343; rs3743229; rs3743228; rs8192349; rs3743227; rs8192347; rs8192346; rs3759902; rs11558360; rs11558350; rs11558353; rs11558354; rs2959910; rs11558375; rs11558352; rs11558357; rs11558370; rs17853396; rs11558365; rs11558371; rs11558368; rs8192411; rs11558359; rs11558378; rs8192407; rs11558376; rs11558356; rs11558367; rs3021075; rs8192366; rs8192389; rs35255865; rs12900318; rs8192351; rs35494718; rs1065654; rs28375199; rs8192368; rs8192372; rs35843341; rs8192358; rs34912901; rs8192371; rs28675719; rs34934268; rs10732234; rs7179691; rs10706808; rs11857075; rs8192376; rs11432818; rs8192369; rs2959907; rs8192370; rs2124857; rs35603965; rs3743225; rs8192375; rs8192384; rs12900042; rs12442597; rs8192382; rs1065655; rs36067769; rs35563486; rs8192361; rs8192390; rs11419360; rs34333350; rs8192373; rs8192388; rs8192383; rs8192352; rs34876633; rs34029406; rs2925649; rs8192380; rs3202686; rs8192377; rs8192391; rs41277722; rs34293190; rs10616881; rs8192403; rs2445734; rs10152494; rs12437619; rs8192409; rs8192414; rs8192405; rs28564216; rs7170259; rs35057170; rs12906366; rs2607088; rs34453402; rs12906365; rs2607089; rs2856932; rs35024842; rs12905751; rs12595329; rs11546423; rs8192415; rs2445733; rs2856934; rs35943695; rs8192406; rs8192430; rs12916226; rs8192429; rs2856928; rs2001035; rs34810448; rs8192410; rs34388767; rs28658414; rs12909527; rs2856926; rs2001034; rs8192424; rs8192426; rs2607091; rs34379240; rs762804; rs8192416; rs2607085; rs8043345; rs2445732; rs35783339; rs8192428; rs2856930; rs8028169; rs2001033; rs28493222; rs2856927; rs2607092; rs8192423; rs12438957; rs34765962; rs12905909; rs2445735; rs2856933; rs2607086; rs12905910; rs34787795; rs35471277; rs35278688; rs2607093; rs2607087; rs34454887; rs11356526; rs8028636; rs8192398; rs12906394; rs8192427; rs8192421; rs8023910; rs2607084; rs8192345; rs35618475; rs1895872; rs8192344; rs8192348; rs2856931; rs35664254; rs2607082; rs2607083; rs1044144; rs1044151; rs10851850; rs12324744; rs12443060; rs1457030; rs2959901; rs35285520; rs35378070; rs4238451; rs4777492; rs7173348

# Metabolic_Enzyme_42_General_References:
2854097; 2813362; 2040271; 12665801; 9466265

# Metabolic_Enzyme_42_References:
Not Available

# Metabolic_Enzyme_43_ID:
6040

# Metabolic_Enzyme_43_Name:
Phosphatidate cytidylyltransferase 1

# Metabolic_Enzyme_43_Synonyms:
CDP-diglyceride synthetase 1; CDP-diglyceride pyrophosphorylase 1; CDP- diacylglycerol synthase 1; CDS 1; CTP:phosphatidate cytidylyltransferase 1; CDP-DAG synthase 1; CDP-DG synthetase 1

# Metabolic_Enzyme_43_Gene_Name:
CDS1

# Metabolic_Enzyme_43_Protein_Sequence:
>Phosphatidate cytidylyltransferase 1
MLELRHRGSCPGPREAVSPPHREGEAAGGDHETESTSDKETDIDDRYGDLDSRTDSDIPE
IPPSSDRTPEILKKALSGLSSRWKNWWIRGILTLTMISLFFLIIYMGSFMLMLLVLGIQV
KCFHEIITIGYRVYHSYDLPWFRTLSWYFLLCVNYFFYGETVADYFATFVQREEQLQFLI
RYHRFISFALYLAGFCMFVLSLVKKHYRLQFYMFAWTHVTLLITVTQSHLVIQNLFEGMI
WFLVPISSVICNDITAYLFGFFFGRTPLIKLSPKKTWEGFIGGFFSTVVFGFIAAYVLSK
YQYFVCPVEYRSDVNSFVTECEPSELFQLQTYSLPPFLKAVLRQERVSLYPFQIHSIALS
TFASLIGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVHVYITSFIRG
PNPSKVLQQLLVLQPEQQLNIYKTLKTHLIEKGILQPTLKV

# Metabolic_Enzyme_43_Number_of_Residues:
461

# Metabolic_Enzyme_43_Molecular_Weight:
53305

# Metabolic_Enzyme_43_Theoretical_pI:
8.19

# Metabolic_Enzyme_43_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  phosphatidate cytidylyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  phospholipid metabolism
Process:  phospholipid biosynthesis
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_43_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_43_Specific_Function:
Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells

# Metabolic_Enzyme_43_Pathway:
map00564  Glycerophospholipid metabolism;
 map04070  Phosphatidylinositol signaling system

# Metabolic_Enzyme_43_Reaction:
CTP + phosphatidate = diphosphate + CDP-diacylglycerol

# Metabolic_Enzyme_43_Pfam_Domain_Function:
PF01148:CTP_transf_1

# Metabolic_Enzyme_43_Signals:
None

# Metabolic_Enzyme_43_Transmembrane_Regions:
96-116
149-169
183-203
230-250
279-299
357-377

# Metabolic_Enzyme_43_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_43_EC_Link:
EC 2.7.7.41

# Metabolic_Enzyme_43_GenBank_ID_Protein:
1620512

# Metabolic_Enzyme_43_SwissProt_ID:
CDS1_HUMAN (Q92903)

# Metabolic_Enzyme_43_swissprot_Name:
Not Available

# Metabolic_Enzyme_43_Genecard_id:
CDS1

# Metabolic_Enzyme_43_Geneatlas_id:
CDS1

# Metabolic_Enzyme_43_hgnc_id:
HGNC:1800

# Metabolic_Enzyme_43_PDB_ID:
Not Available

# Metabolic_Enzyme_43_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_43_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_43_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein. Note=Cytoplasmic aspect of the endoplasmic reticulum (By similarity)

# Metabolic_Enzyme_43_Gene_Sequence:
>1335 bp
ATGTTGGAGCTGAGGCACCGGGGAAGCTGCCCCGGCCCCAGGGAAGCGGTGTCGCCGCCA
CACCGCGAGGGAGAGGCGGCCGGCGGCGACCACGAAACCGAGAGCACCAGCGACAAAGAA
ACAGATATTGATGACAGATATGGAGATTTGGATTCCAGAACAGATTCTGATATTCCGGAA
ATTCCACCATCCTCAGATAGAACCCCTGAGATTCTCAAAAAAGCTCTATCTGGTTTATCT
TCAAGGTGGAAAAACTGGTGGATACGTGGAATTCTCACTCTAACTATGATCTCGTTGTTT
TTCCTGATCATCTATATGGGATCCTTCATGCTGATGCTTCTTGTTCTGGGCATCCAAGTG
AAATGCTTCCATGAAATTATCACTATAGGTTATAGAGTCTATCATTCTTATGATCTACCA
TGGTTTAGAACACTAAGTTGGTACTTTCTATTGTGTGTAAACTACTTTTTCTATGGAGAG
ACTGTAGCTGATTATTTTGCTACATTTGTTCAAAGAGAAGAACAACTTCAGTTCCTCATT
CGCTACCATAGATTTATATCATTTGCCCTCTATCTGGCAGGTTTCTGCATGTTTGTACTG
AGTTTGGTGAAGAAACATTATCGTCTGCAGTTTTATATGTTCGCATGGACTCATGTCACT
TTACTGATAACTGTCACTCAGTCACACCTTGTCATCCAAAATCTGTTTGAAGGCATGATA
TGGTTCCTTGTTCCAATATCAAGTGTTATCTGCAATGACATAACTGCTTACCTTTTTGGA
TTTTTTTTTGGGAGAACTCCATTAATTAAGTTGTCTCCTAAAAAGACTTGGGAAGGATTC
ATTGGTGGTTTCTTTTCCACAGTTGTGTTTGGATTCATTGCTGCCTATGTGTTATCCAAA
TACCAGTACTTTGTCTGCCCAGTGGAATACCGAAGTGATGTAAACTCCTTCGTGACAGAA
TGTGAGCCCTCAGAACTTTTCCAGCTTCAGACTTACTCACTTCCACCCTTTCTAAAGGCA
GTCTTGAGACAGGAAAGAGTGAGCTTGTACCCTTTCCAGATCCACAGCATTGCACTGTCA
ACCTTTGCATCTTTAATTGGCCCATTTGGAGGCTTCTTTGCTAGTGGATTCAAAAGAGCC
TTCAAAATCAAGGATTTTGCAAATACCATTCCTGGACATGGTGGGATAATGGACAGATTT
GATTGTCAGTATTTGATGGCAACTTTTGTACATGTGTACATCACAAGTTTTATCCGGGGC
CCAAATCCCAGCAAAGTGCTACAGCAGTTGTTGGTGCTTCAACCTGAACAGCAGTTAAAT
ATATATAAACCCTGA

# Metabolic_Enzyme_43_GenBank_ID_Gene:
U65887

# Metabolic_Enzyme_43_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_43_Locus:
4q21.23

# Metabolic_Enzyme_43_SNPs:
rs36068434; rs17367775; rs1443075; rs1946998; rs2120091; rs7659340; rs11939816; rs7677285; rs6842038; rs2165786; rs11944769; rs10014792; rs17376048; rs6829806; rs17376090; rs1443074; rs10516725; rs12644583; rs17367226; rs11929910; rs4490450; rs11725539; rs1020278; rs2868920; rs3804180; rs3804184; rs10446695; rs10006466; rs11097023; rs17009168; rs11939300; rs11944727; rs10000060; rs3789144; rs7684125; rs9784491; rs2868919; rs17375853; rs12649660; rs11947168; rs12108575; rs7683338; rs12504451; rs17367317; rs13102661; rs17376293; rs11733870; rs4568237; rs1838038; rs6827228; rs34695122; rs1804654; rs11310518; rs3804182; rs6849387; rs41282379; rs36089174; rs9685017; rs35519151; rs12642834; rs13135976; rs28702042; rs17009165; rs33991933; rs35002876; rs35732307; rs35603703; rs35023321; rs11939848; rs36093550; rs6836452; rs34447857; rs35000359; rs28670879; rs34536160; rs34972820; rs28527489; rs13105636; rs11271259; rs17009173; rs34157522; rs34322177; rs11455902; rs7678115; rs6856213; rs41524654; rs12643724; rs10020892; rs6856016; rs11457723; rs3840106; rs7654064; rs34037068; rs7659740; rs35368517; rs6837043; rs34828724; rs35928242; rs34855553; rs10677732; rs35115354; rs13110728; rs17009170; rs34079401; rs6853486; rs34754898; rs28649894; rs34682067; rs28756833; rs7659609; rs35895809; rs10656557; rs34943856; rs9784505; rs35228102; rs34657842; rs34969245; rs7659837; rs3804183; rs35743147; rs6826352; rs3804181; rs11737354; rs13112002; rs35263989; rs10027833; rs10446678; rs34357563; rs3840105; rs28463971; rs9884216; rs28729735; rs13122829; rs7659610; rs10556110; rs33980767; rs7699828; rs7689916; rs7438419; rs13143523; rs41282381; rs10680741; rs34214827; rs35028311; rs34277716; rs34639898; rs1048097; rs1120; rs11724113; rs11725803; rs11726744; rs11731505; rs11735449; rs11735541; rs11947013; rs12508996; rs12512391; rs12640905; rs13152543; rs17009175; rs2868914; rs2868915; rs34960675; rs35909314; rs6838671; rs7665778

# Metabolic_Enzyme_43_General_References:
8863531; 9115637; 9407135; 9806839

# Metabolic_Enzyme_43_References:
Not Available

# Metabolic_Enzyme_44_ID:
6041

# Metabolic_Enzyme_44_Name:
Pyruvate kinase isozymes R/L

# Metabolic_Enzyme_44_Synonyms:
R-type/L-type pyruvate kinase; Red cell/liver pyruvate kinase; Pyruvate kinase 1

# Metabolic_Enzyme_44_Gene_Name:
PKLR

# Metabolic_Enzyme_44_Protein_Sequence:
>Pyruvate kinase isozymes R/L
MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQ
LPAAMADTFL
EHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNF
SHGSHEYHAESIANVREAVES
FAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELV
KGSQVLVTVDPAFRTRGNANTVWVDYPNIVRV
VPVGGRIYIDDGLISLVVQKIGPEGLV
TQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGV
DIVFASFVRKASDVAA
VRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVF
LAQKM
MIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPV
EAVKM
QHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVL
TTTGRSAQLLSRYRPR
AAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRV
QFGIESGKLRGFLRVGDLVIVVTGWRP
GSGYTNIMRVLSIS

# Metabolic_Enzyme_44_Number_of_Residues:
574

# Metabolic_Enzyme_44_Molecular_Weight:
61831

# Metabolic_Enzyme_44_Theoretical_pI:
7.83

# Metabolic_Enzyme_44_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  pyruvate kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_44_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_44_Specific_Function:
ATP + pyruvate = ADP + phosphoenolpyruvate

# Metabolic_Enzyme_44_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00230  Purine metabolism;
 map00620  Pyruvate metabolism;
 map00710  Carbon fixation

# Metabolic_Enzyme_44_Reaction:
ATP + pyruvate = ADP + phosphoenolpyruvate

# Metabolic_Enzyme_44_Pfam_Domain_Function:
PF00224:PK;
PF02887:PK_C

# Metabolic_Enzyme_44_Signals:
None

# Metabolic_Enzyme_44_Transmembrane_Regions:
None

# Metabolic_Enzyme_44_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_44_EC_Link:
EC 2.7.1.40

# Metabolic_Enzyme_44_GenBank_ID_Protein:
3327365

# Metabolic_Enzyme_44_SwissProt_ID:
KPYR_HUMAN (P30613)

# Metabolic_Enzyme_44_swissprot_Name:
Not Available

# Metabolic_Enzyme_44_Genecard_id:
PKLR

# Metabolic_Enzyme_44_Geneatlas_id:
PKLR

# Metabolic_Enzyme_44_hgnc_id:
HGNC:9020

# Metabolic_Enzyme_44_PDB_ID:
1LIU

# Metabolic_Enzyme_44_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_44_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_44_Subcellular_Location:
Not Available

# Metabolic_Enzyme_44_Gene_Sequence:
>1725 bp

ATGTCGATCCAGGAGAACATATCATCCCTGCAGCTTCGGTCATGGGTCTCTAAGTCCCA
AAGAGACTTAG
CAAAGTCCATCCTGATTGGGGCTCCAGGAGGGCCAGCGGGGTATCTGC
GGCGGGCCAGTGTGGCCCAACT
GACCCAGGAGCTGGGCACTGCCTTCTTCCAGCAGCAG
CAGCTGCCAGCTGCTATGGCAGACACCTTCCTG
GAACACCTCTGCCTACTGGACATTGA
CTCCGAGCCCGTGGCTGCTCGCAGTACCAGCATCATTGCCACCA
TCGGGCCAGCATCTC
GCTCCGTGGAGCGCCTCAAGGAGATGATCAAGGCCGGGATGAACATTGCGCGACT
CAAC
TTCTCCCACGGCTCCCACGAGTACCATGCTGAGTCCATCGCCAACGTCCGGGAGGCGGTG
GAGAGC
TTTGCAGGTTCCCCACTCAGCTACCGGCCCGTGGCCATCGCCCTGGACACCAA
GGGACCGGAGATCCGCA
CTGGGATCCTGCAGGGGGGTCCAGAGTCGGAAGTGGAGCTGG
TGAAGGGCTCCCAGGTGCTGGTGACTGT
GGACCCCGCGTTCCGGACGCGGGGGAACGCG
AACACCGTGTGGGTGGACTACCCCAATATTGTCCGGGTC
GTGCCGGTGGGGGGCCGCAT
CTACATTGACGACGGGCTCATCTCCCTAGTGGTCCAGAAAATCGGCCCAG
AGGGACTGG
TGACCCAAGTGGAGAACGGCGGCGTCCTGGGCAGCCGGAAGGGCGTGAACTTGCCAGGGG
C
CCAGGTGGACTTGCCCGGGCTGTCCGAGCAGGACGTCCGAGACCTGCGCTTCGGGGTG
GAGCATGGGGTG
GACATCGTCTTTGCCTCCTTTGTGCGGAAAGCCAGCGACGTGGCTGC
CGTCAGGGCTGCTCTGGGTCCGG
AAGGACACGGCATCAAGATCATCAGCAAAATTGAGA
ACCACGAAGGCGTGAAGAGGTTTGATGAAATCCT
GGAGGTGAGCGACGGCATCATGGTG
GCACGGGGGGACCTAGGCATCGAGATCCCAGCAGAGAAGGTTTTC
CTGGCTCAGAAGAT
GATGATTGGGCGCTGCAACTTGGCGGGCAAGCCTGTTGTCTGTGCCACACAGATGC
TGG
AGAGCATGATTACCAAGCCCCGGCCAACGAGGGCAGAGACAAGCGATGTCGCCAATGCTG
TGCTGGA
TGGGGCTGACTGCATCATGCTGTCAGGGGAGACTGCCAAGGGCAACTTCCCT
GTGGAAGCGGTGAAGATG
CAGCATGCGATTGCCCGGGAGGCAGAGGCCGCAGTGTACCA
CCGGCAGCTGTTTGAGGAGCTACGTCGGG
CAGCGCCACTAAGCCGTGATCCCACTGAGG
TCACCGCCATTGGTGCTGTGGAGGCTGCCTTCAAGTGCTG
TGCTGCTGCCATCATTGTG
CTGACCACAACTGGCCGCTCAGCCCAGCTTCTGTCTCGGTACCGACCTCGG
GCAGCAGT
CATTGCTGTCACCCGCTCTGCCCAGGCTGCCCGCCAGGTCCACTTATGCCGAGGAGTCTT
CC
CCTTGCTTTACCGTGAACCTCCAGAAGCCATCTGGGCAGATGATGTAGATCGCCGGG
TGCAATTTGGCAT
TGAAAGTGGAAAGCTCCGTGGCTTCCTCCGTGTTGGAGACCTGGTG
ATTGTGGTGACAGGCTGGCGACCT
GGCTCCGGCTACACCAACATCATGAGGGTGCTAAG
CATATCCTGA

# Metabolic_Enzyme_44_GenBank_ID_Gene:
AB015983

# Metabolic_Enzyme_44_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_44_Locus:
1q21

# Metabolic_Enzyme_44_SNPs:
rs1052176; rs8177962; rs1052177; rs4620533; rs3762272; rs8177970; rs8177963; rs3020781; rs8177971; rs8177967; rs8177973; rs8177964; rs12067675; rs11264357; rs8177992; rs8177990; rs8177972; rs8177991; rs8177966; rs2071053; rs11264356; rs8177976; rs8177987; rs8177968; rs8177960; rs7524950; rs8177988; rs8177974; rs8177994; rs35957800; rs3020786; rs8177980; rs3020784; rs2990219; rs8177977; rs8177986; rs35869567; rs8177993; rs34562839; rs8177969; rs11802924; rs3020785; rs8177989; rs8177978; rs8177983; rs10565071; rs12040032; rs35792920; rs12032821; rs8177982; rs8177985; rs3020782; rs8177975; rs8177984; rs8177979; rs3020783; rs8177981; rs12741350; rs8177961; rs8177965; rs2990218; rs35700340; rs34748987; rs12037847; rs35615990; rs11264351; rs11264352; rs11264355; rs12032720; rs12033064; rs12043597; rs12049375; rs12118947; rs12239421; rs12726199; rs1888929; rs2297480; rs34218829; rs35001694; rs35362111; rs3814319; rs4971072; rs7520184; rs8847; rs932972

# Metabolic_Enzyme_44_General_References:
1896471; 3126495; 3566732; 8476433; 8664896; 8807089; 9075576; 10087985; 10772876; 2018831; 1536957; 8481523; 8483951; 8161798; 8180378; 7706479; 9090535; 9827908; 9886305; 9482576; 11328279

# Metabolic_Enzyme_44_References:
Not Available

# Metabolic_Enzyme_45_ID:
5339

# Metabolic_Enzyme_45_Name:
Nucleoside diphosphate kinase homolog 5

# Metabolic_Enzyme_45_Synonyms:
NDK-H 5; NDP kinase homolog 5; nm23-H5; Testis-specific nm23 homolog; Inhibitor of p53-induced apoptosis-beta; IPIA-beta

# Metabolic_Enzyme_45_Gene_Name:
NME5

# Metabolic_Enzyme_45_Protein_Sequence:
>Nucleoside diphosphate kinase homolog 5
MEISMPPPQIYVEKTLAIIKPDIVDKEEEIQDIILRSGFTIVQRRKLRLSPEQCSNFYVE
KYGKMFFPNLTAYMSSGPLVAMILARHKAISYWLELLGPNNSLVAKETHPDSLRAIYGTD
DLRNALHGSNDFAAAEREIRFMFPEVIVEPIPIGQAAKDYLNLHIMPTLLEGLTELCKQK
PADPLIWLADWLLKNNPNKPKLCHHPIVEEPY

# Metabolic_Enzyme_45_Number_of_Residues:
212

# Metabolic_Enzyme_45_Molecular_Weight:
24237

# Metabolic_Enzyme_45_Theoretical_pI:
6.25

# Metabolic_Enzyme_45_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  nucleoside diphosphate kinase activity
 ||
>>>
Process:  CTP biosynthesis
Process:  nucleoside triphosphate metabolism
Process:  nucleoside triphosphate biosynthesis
Process:  ribonucleoside triphosphate biosynthesis
Process:  pyrimidine ribonucleoside triphosphate biosynthesis
Process:  UTP biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside triphosphate biosynthesis
Process:  purine ribonucleoside triphosphate biosynthesis
Process:  GTP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_45_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_45_Specific_Function:
Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species

# Metabolic_Enzyme_45_Pathway:
Not Available

# Metabolic_Enzyme_45_Reaction:
Not Available

# Metabolic_Enzyme_45_Pfam_Domain_Function:
PF05186:Dpy-30;
PF00334:NDK

# Metabolic_Enzyme_45_Signals:
None

# Metabolic_Enzyme_45_Transmembrane_Regions:
None

# Metabolic_Enzyme_45_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_45_EC_Link:
EC 2.7.4.6

# Metabolic_Enzyme_45_GenBank_ID_Protein:
3559927

# Metabolic_Enzyme_45_SwissProt_ID:
NDK5_HUMAN (P56597)

# Metabolic_Enzyme_45_swissprot_Name:
Not Available

# Metabolic_Enzyme_45_Genecard_id:
NME5

# Metabolic_Enzyme_45_Geneatlas_id:
NME5

# Metabolic_Enzyme_45_hgnc_id:
HGNC:7853

# Metabolic_Enzyme_45_PDB_ID:
Not Available

# Metabolic_Enzyme_45_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_45_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_45_Subcellular_Location:
Not Available

# Metabolic_Enzyme_45_Gene_Sequence:
>639 bp
ATGGAGATATCAATGCCTCCACCTCAGATATATGTAGAAAAAACTCTGGCCATTATCAAA
CCAGATATTGTTGACAAAGAGGAGGAGATACAAGATATTATTCTTAGATCCGGATTCACC
ATTGTTCAGAGAAGAAAACTACGCCTCAGCCCTGAGCAATGTAGTAACTTTTATGTGGAA
AAGTATGGAAAAATGTTTTTCCCCAACTTAACAGCTTACATGAGTTCTGGACCACTTGTC
GCCATGATATTAGCTAGACATAAAGCCATCTCTTATTGGTTAGAACTTTTGGGACCAAAT
AATAGCTTAGTAGCGAAGGAGACACATCCAGACAGTCTGAGGGCAATTTATGGCACAGAT
GACCTAAGGAATGCACTTCATGGGAGTAATGACTTTGCTGCTGCGGAAAGAGAAATACGT
TTTATGTTTCCTGAAGTGATTGTTGAGCCCATTCCAATTGGACAAGCTGCTAAGGACTAT
TTAAATTTACATATAATGCCAACTCTGCTTGAAGGACTCACAGAGCTTTGTAAGCAAAAA
CCAGCAGACCCTTTGATTTGGCTAGCTGATTGGCTGCTGAAAAATAATCCTAACAAACCC
AAACTTTGTCACCATCCAATTGTAGAAGAACCTTATTAA

# Metabolic_Enzyme_45_GenBank_ID_Gene:
Y14992

# Metabolic_Enzyme_45_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_45_Locus:
5q31

# Metabolic_Enzyme_45_SNPs:
rs4835669; rs3849045; rs11738864; rs435570; rs486835; rs370883; rs486799; rs6874360; rs10041215; rs2286062; rs217275; rs6886939; rs217257; rs10061967; rs6874361; rs217265; rs11749224; rs10070451; rs34855110; rs1048921; rs1048930; rs217279; rs188654; rs7732940; rs217276; rs34623624; rs9687237; rs217278; rs11428296; rs13163071; rs34303869; rs35881974; rs217277; rs13163059; rs36105476; rs191968; rs35122788; rs34325179; rs4493669; rs407345; rs488701; rs12519826; rs35219466; rs6878575; rs17171760; rs34413149; rs217280; rs184268; rs217266; rs35475097; rs11411365; rs6886543; rs10463966; rs13186134; rs34216437; rs11461484; rs10076479; rs35131457; rs34858006; rs35500548; rs11403625; rs170087; rs35226190; rs11333316; rs13185644; rs12516561; rs13357290; rs217263; rs2306111; rs34936068; rs35406608; rs412051; rs423258; rs4835768; rs528729; rs529526; rs7720650

# Metabolic_Enzyme_45_General_References:
9742940

# Metabolic_Enzyme_45_References:
Not Available

# Metabolic_Enzyme_46_ID:
5313

# Metabolic_Enzyme_46_Name:
Ectonucleoside triphosphate diphosphohydrolase 1

# Metabolic_Enzyme_46_Synonyms:
NTPDase 1; Ecto-ATP diphosphohydrolase; ATPDase; Lymphoid cell activation antigen; Ecto-apyrase; CD39 antigen

# Metabolic_Enzyme_46_Gene_Name:
ENTPD1

# Metabolic_Enzyme_46_Protein_Sequence:
>Ectonucleoside triphosphate diphosphohydrolase 1
MEDTKESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENVKYGIVLDAGSSHT
SLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQ
HQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWI
TINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFR
LYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTP
CTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAF
SAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYIL
SLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVFL
MVLFSLVLFTVAIIGLLIFHKPSYFWKDMV

# Metabolic_Enzyme_46_Number_of_Residues:
510

# Metabolic_Enzyme_46_Molecular_Weight:
57965

# Metabolic_Enzyme_46_Theoretical_pI:
6.29

# Metabolic_Enzyme_46_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_46_General_Function:
Not Available

# Metabolic_Enzyme_46_Specific_Function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation. Hydrolyzes ATP and ADP equally well

# Metabolic_Enzyme_46_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_46_Reaction:
ATP + 2 H2O = AMP + 2 phosphate

# Metabolic_Enzyme_46_Pfam_Domain_Function:
PF01150:GDA1_CD39

# Metabolic_Enzyme_46_Signals:
None

# Metabolic_Enzyme_46_Transmembrane_Regions:
17-37
479-499

# Metabolic_Enzyme_46_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_46_EC_Link:
EC 3.6.1.5

# Metabolic_Enzyme_46_GenBank_ID_Protein:
765256

# Metabolic_Enzyme_46_SwissProt_ID:
ENTP1_HUMAN (P49961)

# Metabolic_Enzyme_46_swissprot_Name:
Not Available

# Metabolic_Enzyme_46_Genecard_id:
ENTPD1

# Metabolic_Enzyme_46_Geneatlas_id:
ENTPD1

# Metabolic_Enzyme_46_hgnc_id:
HGNC:3363

# Metabolic_Enzyme_46_PDB_ID:
Not Available

# Metabolic_Enzyme_46_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_46_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_46_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential)

# Metabolic_Enzyme_46_Gene_Sequence:
>1533 bp
ATGGAAGATACAAAGGAGTCTAACGTGAAGACATTTTGCTCCAAGAATATCCTAGCCATC
CTTGGCTTCTCCTCTATCATAGCTGTGATAGCTTTGCTTGCTGTGGGGTTGACCCAGAAC
AAAGCATTGCCAGAAAACGTTAAGTATGGGATTGTGCTGGATGCGGGTTCTTCTCACACA
AGTTTATACATCTATAAGTGGCCAGCAGAAAAGGAGAATGACACAGGCGTGGTGCATCAA
GTAGAAGAATGCAGGGTTAAAGGTCCTGGAATCTCAAAATTTGTTCAGAAAGTAAATGAA
ATAGGCATTTACCTGACTGATTGCATGGAAAGAGCTAGGGAAGTGATTCCAAGGTCCCAG
CACCAAGAGACACCCGTTTACCTGGGAGCCACGGCAGGCATGCGGTTGCTCAGGATGGAA
AGTGAAGAGTTGGCAGACAGGGTTCTGGATGTGGTGGAGAGGAGCCTCAGCAACTACCCC
TTTGACTTCCAGGGTGCCAGGATCATTACTGGCCAAGAGGAAGGTGCCTATGGCTGGATT
ACTATCAACTATCTGCTGGGCAAATTCAGTCAGAAAACAAGGTGGTTCAGCATAGTCCCA
TATGAAACCAATAATCAGGAAACCTTTGGAGCTTTGGACCTTGGGGGAGCCTCTACACAA
GTCACTTTTGTACCCCAAAACCAGACTATCGAGTCCCCAGATAATGCTCTGCAATTTCGC
CTCTATGGCAAGGACTACAATGTCTACACACATAGCTTCTTGTGCTATGGGAAGGATCAG
GCACTCTGGCAGAAACTGGCCAAGGACATTCAGGTTGCAAGTAATGAAATTCTCAGGGAC
CCATGCTTTCATCCTGGATATAAGAAGGTAGTGAACGTAAGTGACCTTTACAAGACCCCC
TGCACCAAGAGATTTGAGATGACTCTTCCATTCCAGCAGTTTGAAATCCAGGGTATTGGA
AACTATCAACAATGCCATCAAAGCATCCTGGAGCTCTTCAACACCAGTTACTGCCCTTAC
TCCCAGTGTGCCTTCAATGGGATTTTCTTGCCACCACTCCAGGGGGATTTTGGGGCATTT
TCAGCTTTTTACTTTGTGATGAAGTTTTTAAACTTGACATCAGAGAAAGTCTCTCAGGAA
AAGGTGACTGAGATGATGAAAAAGTTCTGTGCTCAGCCTTGGGAGGAGATAAAAACATCT
TACGCTGGAGTAAAGGAGAAGTACCTGAGTGAATACTGCTTTTCTGGTACCTACATTCTC
TCCCTCCTTCTGCAAGGCTATCATTTCACAGCTGATTCCTGGGAGCACATCCATTTCATT
GGCAAGATCCAGGGCAGCGACGCCGGCTGGACTTTGGGCTACATGCTGAACCTGACCAAC
ATGATCCCAGCTGAGCAACCATTGTCCACACCTCTCTCCCACTCCACCTATGTCTTCCTC
ATGGTTCTATTCTCCCTGGTCCTTTTCACAGTGGCCATCATAGGCTTGCTTATCTTTCAC
AAGCCTTCATATTTCTGGAAAGATATGGTATAG

# Metabolic_Enzyme_46_GenBank_ID_Gene:
S73813

# Metabolic_Enzyme_46_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_46_Locus:
10q24

# Metabolic_Enzyme_46_SNPs:
rs3793744; rs3181132; rs1342790; rs3176883; rs3181124; rs1573112; rs3176891; rs2153913; rs3176890; rs10748643; rs7077566; rs4431963; rs6584033; rs4582902; rs10882665; rs6584026; rs2185818; rs10748649; rs4075310; rs3176881; rs5014871; rs7097489; rs7919196; rs4481960; rs4918968; rs10882664; rs1891534; rs7096610; rs10509686; rs7083960; rs4322324; rs3892344; rs3181123; rs4396219; rs4512761; rs4917715; rs7921242; rs7074403; rs1891536; rs4244321; rs2861152; rs1418709; rs3181131; rs2275759; rs4075311; rs10882671; rs4917714; rs1340837; rs6584027; rs3176885; rs7088952; rs12262943; rs11598475; rs4320886; rs17111156; rs11188486; rs10882676; rs7096248; rs3929900; rs4918969; rs4551688; rs7093453; rs3897983; rs2901874; rs10882673; rs4918971; rs2901873; rs2861153; rs6584031; rs10736092; rs7893677; rs3181129; rs4917707; rs11188497; rs7088961; rs7902190; rs10882660; rs2105359; rs6584028; rs7901116; rs7913082; rs10736093; rs3176884; rs7900927; rs4614366; rs10786236; rs2901872; rs7067762; rs11188485; rs7089668; rs4409759; rs7070507; rs11595122; rs10882670; rs10786235; rs1539433; rs7100137; rs7088584; rs11818540; rs10748648; rs4336964; rs10882675; rs1342791; rs4074424; rs4918970; rs3181122; rs12767650; rs3901451; rs11816167; rs11188475; rs3181121; rs7915345; rs3176887; rs2861151; rs6584030; rs4412693; rs11594340; rs7921000; rs7894940; rs3176882; rs7898379; rs11188496; rs3181118; rs3176886; rs10882661; rs10882666; rs7901386; rs2275760; rs7090320; rs12770849; rs3181125; rs7915682; rs3901450; rs11188501; rs10786237; rs7900546; rs10748644; rs10786234; rs7915087; rs7913018; rs7894676; rs7914736; rs1935816; rs1418710; rs10748645; rs10786233; rs7069234; rs4406763; rs10882662; rs11188502; rs7915308; rs3176889; rs7095489; rs11593761; rs7082531; rs7914286; rs2861154; rs7083411; rs3176888; rs10882663; rs7920372; rs10748647; rs12780375; rs12354848; rs7476775; rs11188484; rs11188495; rs12763743; rs10882668; rs4272738; rs11188488; rs7900841; rs7921302; rs11188492; rs10786238; rs12244606; rs7915499; rs10882669; rs11188498; rs7904990; rs11592584; rs12770313; rs10882674; rs11188504; rs3181127; rs7915380; rs3176894; rs3814159; rs3176893; rs3176895; rs3176892; rs1804825; rs12240959; rs4463786; rs34293555; rs34399092; rs35135296; rs11389794; rs3980180; rs10736091; rs11407296; rs11188487; rs11597953; rs11188493; rs5787157; rs4472866; rs4539246; rs34736818; rs34473397; rs35488296; rs35597960; rs4420188; rs35620983; rs5787162; rs9663685; rs35826614; rs7900437; rs34166835; rs10585205; rs11188508; rs34177114; rs36017526; rs3181128; rs10672739; rs4581382; rs5787158; rs12354620; rs12265109; rs11188494; rs11188482; rs4433506; rs34836127; rs34248770; rs35444953; rs35537802; rs3980181; rs34907927; rs35452058; rs34858625; rs7896855; rs35809029; rs11517041; rs11188479; rs35615283; rs34279173; rs12360382; rs34421483; rs34720050; rs34980662; rs35782220; rs11574649; rs11393527; rs7909739; rs7088411; rs12572063; rs34872816; rs12258207; rs5787161; rs11188481; rs11188511; rs28542865; rs35164560; rs4917705; rs7900229; rs11527887; rs35203111; rs3897464; rs34082135; rs34627984; rs35360884; rs11188509; rs34308669; rs35650706; rs11188506; rs4325249; rs35298724; rs35859772; rs11188510; rs5787159; rs1418711; rs11574648; rs34367283; rs34925455; rs34296389; rs11188480; rs11528098; rs34873600; rs7898964; rs34863917; rs11188489; rs34997042; rs3961946; rs35748815; rs35177231; rs12357414; rs11188490; rs12355114; rs34077465; rs35535706; rs35825117; rs35417010; rs9702308; rs4481957; rs35854596; rs11188505; rs7911911; rs5787163; rs34850860; rs12782273; rs11188477; rs11188491; rs12774334; rs3897465; rs11188473; rs9664384; rs11188503; rs33998152; rs11188483; rs4402217; rs35861909; rs35700869; rs3961947; rs35516259; rs11498722; rs5787160; rs34143181; rs10736094; rs11188466; rs11188469; rs11188471; rs11188512; rs11188513; rs11188514; rs12358481; rs12761960; rs12775598; rs12781189; rs17462179; rs17553401; rs1935815; rs2051052; rs2096218; rs2153914; rs2226163; rs3181114; rs3181115; rs3181116; rs3192654; rs34630379; rs34793678; rs4918966; rs6584022; rs6584023; rs7086986; rs7090630; rs7096317; rs7098750; rs7100644; rs7923971

# Metabolic_Enzyme_46_General_References:
7930580; 8996251; 10405171; 8529670; 9846014; 8955160; 8626624; 10636909

# Metabolic_Enzyme_46_References:
Not Available

End of HMDB00082

Beginning of HMDB00085
# Accession_No:
HMDB00085

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-12 16:52:53

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Deoxyguanosine

# Description:
A nucleoside consisting of the base guanine and the sugar deoxyribose. It is like guanosine, but with one oxygen atom removed. It is a nucleoside component of DNA.  Deoxyguanosine can be converted to 8-hydroxy-deoxyguanosine (8-OHdG) due to hydroxyl radical attack at the C8 of guanine.  8-OHdG is a sensitive marker of the DNA damage This damage, if left unrepaired, has been proposed to contribute to mutagenicity and cancer promotion.

# Synonyms:
2'-Deoxyguanosine; 2'-deoxy-Guanosine; 2-Deoxyguanosine; 9-(2-Deoxy-b-D-erythro-pentofuranosyl)guanine; 9-(2-deoxy-b-D-erythro-pentofuranosyl)-Guanine; Deoxyguanosine; Desoxyguanosine; Guanine deoxy nucleoside; Guanine deoxyriboside; 9-(2-Deoxy-beta-delta-erythro-pentofuranosyl)guanine; 9-(2-deoxy-beta-delta-erythro-pentofuranosyl)-Guanine

# Chemical_IUPAC_Name:
2-amino-9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one

# Chemical_Formula:
C10H13N5O4

# Chemical_Structure:
tbl_chemical:::HMDB00085_ZOOM.png:::119283180937297885

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00085_THUMB.png:::119283180738481977

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines; Nucleosides

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; primary alcohol; secondary alcohol; primary amine; primary aromatic amine; oxo(het)arene; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of Purine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
267.09674

# Molecular_Weight_Avg:
267.24130

# Smiles_String_isomeric:
NC1=NC2=C(N=CN2[C@H]3C[C@H](O)[C@@H](CO)O3)C(=O)N1

# Smiles_String_canonical:
NC1=NC2=C(N=CN2C3CC(O)C(CO)O3)C(=O)N1

# KEGG_Compound_ID:
C00330

# BioCyc_ID:
DEOXYGUANOSINE

# PubChem_CID:
187790

# PubChem_SID:
841363; 7886569; 11532111; 10260700; 596780; 3139600; 1096435; 765278; 8143666; 10555472; 830199; 11534253; 3624

# OMIM_ID:
164050; 232700

# Metagene_ID:
Not Available

# BiGG_ID:
34637

# Wikipedia_ID:
Deoxyguanosine

# METLIN_ID:
3395

# Ref_ID:
16111881; 9288892; 16251187; 11732622; 11592983; 15073048; 1637681; 12209966; 12898156; 16766390; 11528234; 10102915; 12424330; 6765955; 11525870; 12084452; 7697806; 11026616; 8575417; 8564935

# ChEBI_ID:
17172

# CAS_Registry_Number:
961-07-9

# InChI:
InChI=1/C10H13N5O4/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6/h3-6,16-17H,1-2H2,(H3,11,13,14,18)/t4-,5+,6+/m0/s1

# Synthesis_Reference:
A new set of easily removable protecting groups for oligonucleotide synthesis.     Schulhof, J. C.; Molko, D.; Teoule, R.    Dep. Rech. Fondam.,  Cent. Etud. Nucl. Grenoble,  Grenoble,  Fr.    Bioactive Molecules  (1987),  3(Biophosphates Their Analogues)

# Melting_Point:
300 oC

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
12.0 mg/mL [MEYLAN,WM et al. (1996)]; 11.5 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-1.30 [BALZARINI,JM ET AL. (1989)]

# LogP_predicted:
-1.75 [Predicted by ALOGPS]; -1.1 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::2&#8242;-Deoxyguanosine Hydrate.pdf:::1132562198136274142

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Deoxyguanosine.mol:::1132723806031478616

# SDF_File_[Text]:
tbl_chemical:::HMDB00085.sdf:::119283180313637105

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00085.pdb:::119283180600187977

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041104_P00_05_HW_1DP_presat.png:::114859292136260909

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041104_P00_05_HW_1DP_presat.zip:::114859292137165809

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041104_P00_05_HW_1DP.png:::117408599423576117

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041104_P00_05_HW_2DHSQC_644.png:::114789969760881659

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041104_P00_05_HW_2DHSQC_644.zip:::114789969762813174

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041104_P00_05_HW_2DHSQC_644_Assigned.png:::11624867556351377

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Deoxyguanosine.gif:::1132732106546906204

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00085_peaks.txt:::1156309534828101682

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Deoxyguanosine_C.gif:::1132737678197709101

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00085_peaks.txt:::1156310725158738482

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00085L.png:::117555262343988164; Medium Energy:tbl_ms:::HMDB00085M.png:::117555267701052812; High Energy:tbl_ms:::HMDB00085H.png:::117555271285067534

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000003.png:::116890821614026418

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000003.txt:::116890821614029917

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000003.png:::116890821590675214

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000003.txt:::116890821614023298

# Cellular_Location:
Cytoplasm; Nucleus; Extracellular; lysosome; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	<1.0	umol/mmol_creatinine	Adult:>18_yrs_old	N/A	Normal	10102915


# Concentration_[Abnormal]:
Urine	177.0-322.0	umol/mmol_creatinine	Adult:>18_yrs_old	N/A	Purine Nucleoside Phosphorylase Deficiency	10102915


# Associated_Disorders:
Bladder Cancer; Diabetic Nephropathy; Meningitis; Purine Nucleoside Phosphorylase Deficiency

# Pathway_Names:
Purine metabolism;Nicotinate and nicotinamide metabolism

# Pathway_Images:
Purine_Synthesis.jpg;Nicotinamide_synthesis_(NADH).jpg

# KEGG_Images:
map00230;map00760

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;Nicotinamide_synthesis_(NADH)_Graph.jpg

# Pathway_SBMLs:
Purine_Synthesis.xml;Nicotinamide_synthesis_(NADH).xml

# Metabolic_Enzyme_1_ID:
5234

# Metabolic_Enzyme_1_Name:
5'(3')-deoxyribonucleotidase, cytosolic type

# Metabolic_Enzyme_1_Synonyms:
Cytosolic 5',3'-pyrimidine nucleotidase; Deoxy-5'-nucleotidase 1; dNT-1

# Metabolic_Enzyme_1_Gene_Name:
NT5C

# Metabolic_Enzyme_1_Protein_Sequence:
>5'3'deoxyribonucleotidase, cytosolic type
MARSVRVLVDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADK
VASVYEAPGFFLDLEPIPGALDAVREMNDLPDTQVFICTSPLLKYHHCVGEKYRWVEQHL
GPQFVERIILTRDKTVVLGDLLIDDKDTVRGQEETPSWEHILFTCCHNRHLVLPPTRRRL
LSWSDNWREILDSKRGAAQRE

# Metabolic_Enzyme_1_Number_of_Residues:
201

# Metabolic_Enzyme_1_Molecular_Weight:
23383

# Metabolic_Enzyme_1_Theoretical_pI:
6.63

# Metabolic_Enzyme_1_GO_Classification:
Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP

# Metabolic_Enzyme_1_Pathway:
Not Available

# Metabolic_Enzyme_1_Reaction:
Not Available

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
7524492

# Metabolic_Enzyme_1_SwissProt_ID:
NT5C_HUMAN (Q8TCD5)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
NT5C

# Metabolic_Enzyme_1_Geneatlas_id:
NT5C

# Metabolic_Enzyme_1_hgnc_id:
HGNC:17144

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>606 bp
ATGGCGCGGAGCGTGCGCGTGCTGGTGGACATGGACGGCGTCCTGGCCGACTTCGAGGCC
GGCCTCCTGCGGGGCTTCCGCCGCCGCTTCCCTGAGGAGCCGCACGTGCCGCTGGAGCAA
CGCCGCGGCTTCCTGGCCCGCGAGCAGTACCGCGCCCTGCGGCCCGACCTGGCGGATAAA
GTGGCCAGTGTGTACGAAGCCCCGGGCTTTTTCCTGGACCTGGAGCCCATCCCGGGAGCC
TTGGACGCTGTGCGGGAGATGAACGACCTACCGGACACGCAGGTCTTCATCTGCACCAGC
CCCCTGCTGAAGTACCACCACTGTGTGGGTGAGAAGTACCGCTGGGTGGAGCAGCACCTG
GGGCCCCAGTTCGTAGAACGAATTATCCTGACAAGGGACAAGACGGTGGTCTTGGGGGAC
CTGCTCATTGATGACAAGGACACAGTTCGAGGCCAGGAGGAGACCCCAAGCTGGGAGCAC
ATCTTGTTCACCTGCTGCCACAATCGGCACCTGGTCCTGCCCCCGACAAGGAGACGGCTG
CTCTCCTGGAGTGACAACTGGAGGGAGATCTTAGATAGCAAGCGCGGAGCTGCGCAGCGG
GAATGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF154829

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_1_Locus:
17q25.1

# Metabolic_Enzyme_1_SNPs:
rs4788867; rs11868451; rs3736076; rs3736075; rs12453556; rs4789144; rs11652099; rs4789143; rs11541956; rs12945569; rs3188816; rs12946860; rs1048779; rs12943507; rs34746270; rs11541955; rs12945517; rs9910084; rs34454120; rs7406461; rs4788868; rs11868212; rs1551966; rs2291027; rs2291028; rs34338273; rs3752801; rs4412997; rs4789145; rs750843; rs750844; rs899316; rs899317

# Metabolic_Enzyme_1_General_References:
10681516; 12234672

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5232

# Metabolic_Enzyme_2_Name:
Cytosolic 5'-nucleotidase 1B

# Metabolic_Enzyme_2_Synonyms:
Cytosolic 5'-nucleotidase IB; cN1B; cN-IB; Autoimmune infertility-related protein

# Metabolic_Enzyme_2_Gene_Name:
NT5C1B

# Metabolic_Enzyme_2_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
BMSQTSLKQKKNEPGMRSSKESLEAEKRKESDKTGVRLSNQMRRAVNPNHSLRCCPFQGH
SSCRRCLCAAEGTALGPCHTIRIYIHMCLLWEQGQQITMMRGSQESSLRKTDSRGYLVRS
QWSRISRSPSTKAPSIDEPRSRNTSAKLPSSSTSSRTPSTSPSLHDSSPPPLSGQPSLQP
PASPQLPRSLDSRPPTPPEPDPGSRRSTKMQENPEAWAQGIVREIRQTRDSQPLEYSRTS
PTEWKSSSQRRGIYPASTQLDRNSLSEQQQQQREDEDDYEAAYWASMRSFYEKNPSCSRP
WPPKPKNAITIALSSCALFNMVDGRKIYEQEGLEKYMEYQLTNENVILTPGPAFRFVKAL
QYVNARLRDLYPDEQDLFDIVLMTNNHAQVGVRLINSVNHYGLLIDRFCLTGGKDPIGYL
KAYLTNLYIAADSEKVQEAIQEGIASATMFDGAKDMAYCDTQLRVAFDGDAVLFSDESEH
FTKEHGLDKFFQYDTLCESKPLAQGPLKGFLEDLGRLQKKFYAKNERLLCPIRTYLVTAR
SAASSGARVLKTLRRWGLEIDEALFLAGAPKSPILVKIRPHIFFDDHMFHIEGAQRLGSI
AAYGFNKKFSS

# Metabolic_Enzyme_2_Number_of_Residues:
610

# Metabolic_Enzyme_2_Molecular_Weight:
68804

# Metabolic_Enzyme_2_Theoretical_pI:
9.03

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels

# Metabolic_Enzyme_2_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_2_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
13774961

# Metabolic_Enzyme_2_SwissProt_ID:
5NT1B_HUMAN (Q96P26)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
NT5C1B

# Metabolic_Enzyme_2_Geneatlas_id:
NT5C1B

# Metabolic_Enzyme_2_hgnc_id:
HGNC:17818

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1699 bp
GGGCAAAAATGTGGATAACAACAAAAGAATTTCAACAGGTAAAAAAATGAGTCAAACATC
TCTCAAACAGAAAAAGAATGAGCCCGGAATGAGGTCCTCAAAAGAGAGTCTAGAAGCAGA
AAAAAGAAAGGAATCTGACAAAACAGGAGTTCGTCTGAGCAATCAGGGATCACAAGAATC
ATCACTGCGGAAGACAGACTCTCGAGGGTACCTTGTGCGCAGTCAATGGTCTAGAATATC
CCGGAGCCCATCCACCAAGGCTCCATCCATAGATGAGCCTAGAAGCAGGAACACCAGTGC
TAAGCTCCCCAGCAGCTCCACGAGCTCCCGGACTCCATCCACCTCCCCAAGCCTGCATGA
CTCCTCACCGCCGCCGCTGTCCGGGCAGCCCTCGCTCCAGCCACCCGCGTCGCCCCAGCT
GCCCCGGTCGCTGGACTCGCGGCCTCCCACGCCCCCAGAGCCCGATCCTGGCTCCCGGCG
CAGCACCAAAATGCAAGAAAATCCGGAGGCCTGGGCCCAAGGCATCGTGCGGGAAATCCG
CCAGACCCGGGACTCGCAGCCGCTGGAATATTCGCGCACGTCCCCCACCGAGTGGAAGTC
CTCCAGCCAGCGCAGGGGGATCTACCCCGCCTCCACCCAGCTGGACCGCAACTCTCTGTC
CGAGCAGCAGCAGCAGCAGCGGGAGGACGAAGACGACTACGAAGCTGCCTACTGGGCATC
CATGAAGTCGTTCTACGAAAAGAACCCGAGCTGCTGGCGCCCCTGGCCGCCCAAACCCAA
GAACGCCATCACCATTGCTCTCTCATCCTGCGCGCTCTTCAACATGGTGGACGGCAGGAA
AATCTACGAGCAAGAGGGTCTGGAAAAGTACATGGAGTATCAGCTCACCAATGAGAACGT
CATCCTGACCCCGGGCCCGGCGTTCCGTTTCGTCAAGGCACTACAGTATGTCAATGCTAG
ACTCCGTGATCTATATCCTGATGAACAGGACTTATTTGATATTGTACTGATGACTAATAA
CCATGCCCAAGTGGGAGTGCGGCTTATAAACAGCGTCAATCACTACGGCTTACTGATTGA
CCGCTTCTGTCTGACCGGGGGAAAAGACCCCATTGGCTATTTGAAGGCATATCTTACCAA
CTTGTATATTGCTGCAGATTCTGAAAAAGTGCAAGAGGCAATACAAGAAGGTATTGCCTC
TGCGACAATGTTTGATGGAGCCAAAGACATGGCTTACTGTGACACTCAGCTCCGTGTAGC
CTTTGATGGGGATGCTGTCCTCTTCTCTGATGAGTCTGAACATTTTACCAAGGAGCATGG
GCTGGACAAATTCTTCCAGTATGATACATTATGTGAAAGTAAGCCTCTTGCTCAGGGTCC
CCTAAAAGGCTTTCTGGAAGATTTAGGCAGACTGCAAAAGAAGTTCTATGCCAAAAATGA
ACGGTTACTTTGTCCTATCAGGACCTACCTGGTTACAGCTAGGAGTGCAGCCAGTTCAGG
CGCCCGTGTGCTGAAAACCTTCCGACGCTGGGGTCTAGAGATAGACGAAGCTCTTTTCCT
TGCTGGAGCCCCCAAAAGTCCCATCTTGGTGAAGATCCGGCCCCACATCTTCTTTGATGA
CCACATGTTCCACATTGAAGGGGCACAGAGGTTAGGTTCCATCGCAGCTTATGGCTTTAA
TAAAAAATTCAGTAGTTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF356185

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_2_Locus:
2p24.2

# Metabolic_Enzyme_2_SNPs:
rs3902946; rs16985301; rs16985306; rs3747660; rs2346137; rs6720633; rs7594728; rs6531109; rs6710367; rs7557821; rs4832608; rs11893074; rs16985296; rs7561652; rs2317857; rs16985292; rs16985290; rs6741218; rs11096544; rs35590292; rs10183289; rs17752103; rs11885013; rs17701334; rs16985293; rs11903725; rs7604190; rs4832609; rs7592099; rs16985311; rs16985310; rs3810839; rs17852342; rs34254789; rs7594519; rs34129467; rs7605480; rs35165251; rs7603601; rs34836771; rs34186303; rs35711606; rs35729409; rs34953851; rs11291136; rs28474708; rs3046807; rs34660980; rs35519366; rs3046840; rs35419885; rs7557722; rs4300829; rs7592233; rs13020403; rs36121694; rs34127788; rs11889898; rs13403096; rs13411442; rs1373776; rs16985281; rs16985284; rs17751951; rs2346135; rs2346136; rs34722188; rs35805648; rs3810838; rs3910894

# Metabolic_Enzyme_2_General_References:
11690631

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5806

# Metabolic_Enzyme_3_Name:
Thymidine phosphorylase precursor

# Metabolic_Enzyme_3_Synonyms:
TdRPase; TP; Platelet-derived endothelial cell growth factor; PD-ECGF; Gliostatin

# Metabolic_Enzyme_3_Gene_Name:
ECGF1

# Metabolic_Enzyme_3_Protein_Sequence:
>Thymidine phosphorylase precursor
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ

# Metabolic_Enzyme_3_Number_of_Residues:
482

# Metabolic_Enzyme_3_Molecular_Weight:
49956

# Metabolic_Enzyme_3_Theoretical_pI:
5.19

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  pyrimidine base metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_3_Reaction:
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF02885:Glycos_trans_3N;
PF00591:Glycos_transf_3;
PF07831:PYNP_C

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.4.2.4

# Metabolic_Enzyme_3_GenBank_ID_Protein:
189701

# Metabolic_Enzyme_3_SwissProt_ID:
TYPH_HUMAN (P19971)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ECGF1

# Metabolic_Enzyme_3_Geneatlas_id:
ECGF1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:3148

# Metabolic_Enzyme_3_PDB_ID:
1UOU

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>1449 bp
ATGGCAGCCTTGATGACCCCGGGAACCGGGGCCCCACCCGCGCCTGGTGACTTCTCCGGG
GAAGGGAGCCAGGGACTTCCCGACCCTTCGCCAGAGCCCAAGCAGCTCCCGGAGCTGATC
CGCATGAAGCGAGACGGAGGCCGCCTGAGCGAAGCGGACATCAGGGGCTTCGTGGCCGCT
GTGGTGAATGGGAGCGCGCAGGGCGCACAGATCGGGGCCATGCTGATGGCCATCCGACTT
CGGGGCATGGATCTGGAGGAGACCTCGGTGCTGACCCAGGCCCTGGCTCAGTCGGGACAG
CAGCTGGAGTGGCCAGAGGCCTGGCGCCAGCAGCTTGTGGACAAGCATTCCACAGGGGGT
GTGGGTGACAAGGTCAGCCTGGTCCTCGCACCTGCCCTGGCGGCATGTGGCTGCAAGGTG
CCAATGATCAGCGGACGTGGTCTGGGGCACACAGGAGGCACCTTGGATAAGCTGGAGTCT
ATTCCTGGATTCAATGTCATCCAGAGCCCAGAGCAGATGCAAGTGCTGCTGGACCAGGCG
GGCTGCTGTATCGTGGGTCAGAGTGAGCAGCTGGTTCCTGCGGACGGAATCCTATATGCA
GCCAGAGATGTGACAGCCACCGTGGACAGCCTGCCACTCATCACAGCCTCCATTCTCAGT
AAGAAACTCGTGGAGGGGCTGTCCGCTCTGGTGGTGGACGTTAAGTTCGGAGGGGCCGCC
GTCTTCCCCAACCAGGAGCAGGCCCGGGAGCTGGCAAAGACGCTGGTTGGCGTGGGAGCC
AGCCTAGGGCTTCGGGTCGCGGCAGCGCTGACCGCCATGGACAAGCCCCTGGGTCGCTGC
GTGGGCCACGCCCTGGAGGTGGAGGAGGCGCTGCTCTGCATGGACGGCGCAGGCCCGCCA
GACTTAAGGGACCTGGTCACCACGCTCGGGGGCGCCCTGCTCTGGCTCAGCGGACACGCG
GGGACTCAGGCTCAGGGCGCTGCCCGGGTGGCCGCGGCGCTGGACGACGGCTCGGCCCTT
GGCCGCTTCGAGCGGATGCTGGCGGCGCAGGGCGTGGATCCCGGTCTGGCCCGAGCCCTG
TGCTCGGGAAGTCCCGCAGAACGCCGGCAGCTGCTGCCTCGCGCCCGGGAGCAGGAGGAG
CTGCTGGCGCCCGCAGATGGCACCGTGGAGCTGGTCCGGGCGCTGCCGCTGGCGCTGGTG
CTGCACGAGCTCGGGGCCGGGCGCAGCCGCGCTGGGGAGCCGCTCCGCCTGGGGGTGGGC
GCAGAGCTGCTGGTCGACGTGGGTCAGAGGCTGCGCCGTGGGACCCCCTGGCTCCGCGTG
CACCGGGACGGCCCCGCGCTCAGCGGCCCGCAGAGCCGCGCCCTGCAGGAGGCGCTCGTA
CTCTCCGACCGCGCGCCATTCGCCGCCCCCTCGCCCTTCGCAGAGCTCGTTCTGCCGCCG
CAGCAATAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M63193

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_3_Locus:
22q13|22q13.33

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
2467210; 1570012; 1400349; 1590793; 9924029; 12177387

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5233

# Metabolic_Enzyme_4_Name:
Cytosolic 5'-nucleotidase 1A

# Metabolic_Enzyme_4_Synonyms:
Cytosolic 5'-nucleotidase IA; cN1A; cN-IA; cN-I

# Metabolic_Enzyme_4_Gene_Name:
NT5C1A

# Metabolic_Enzyme_4_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
AMEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSR
ALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSED
VFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKV
REAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKA
HENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSW
GLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTA
PAKQAPSAQ

# Metabolic_Enzyme_4_Number_of_Residues:
368

# Metabolic_Enzyme_4_Molecular_Weight:
41021

# Metabolic_Enzyme_4_Theoretical_pI:
6.52

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia

# Metabolic_Enzyme_4_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_4_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
12659324

# Metabolic_Enzyme_4_SwissProt_ID:
5NT1A_HUMAN (Q9BXI3)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
NT5C1A

# Metabolic_Enzyme_4_Geneatlas_id:
NT5C1A

# Metabolic_Enzyme_4_hgnc_id:
HGNC:17819

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_4_Gene_Sequence:
>1107 bp
ATGGAACCTGGGCAGCCCCGGGAGCCCCAGGAGCCCCGCGAGCCCGGGCCAGGAGCGGAG
ACCGCTGCGGCCCCGGTCTGGGAGGAAGCCAAGATTTTCTACGACAACCTCGCGCCCAAG
AAGAAACCCAAATCGCCCAAGCCTCAGAATGCAGTCACCATCGCTGTGTCCTCCCGAGCC
TTGTTTCGCATGGACGAGGAGCAGCAGATCTACACGGAGCAGGGCGTGGAGGAGTACGTG
CGCTACCAGCTGGAACATGAGAACGAACCCTTCAGTCCCGGGCCAGCCTTCCCTTTTGTG
AAGGCTCTGGAGGCCGTGAACAGGCGGCTGCGGGAGCTGTACCCTGATAGTGAGGACGTC
TTCGACATCGTCCTCATGACTAACAACCATGCTCAAGTGGGTGTCCGCCTCATCAACAGT
ATCAACCACTATGACCTGTTCATCGAGAGGTTCTGCATGACAGGTGGGAACAGCCCGATC
TGCTACCTCAAGGCCTATCACACCAACCTCTACTTGTCAGCCGATGCGGAAAAAGTGCGA
GAAGCCATTGATGAGGGGATCGCAGCTGCCACCATCTTCAGCCCCAGCAGGGATGTGGTT
GTGTCCCAGAGTCAGCTGCGCGTGGCCTTCGATGGGGACGCCGTGCTCTTCTCGGACGAG
TCGGAGCGCATCGTCAAGGCCCACGGGCTGGACCGATTCTTCGAGCATGAGAAGGCCCAC
GAGAACAAGCCTCTGGCTCAGGGCCCCTTAAAGGGCTTTCTGGAGGCACTGGGTAGGTTG
CAGAAGAAGTTCTACTCCAAAGGCCTGCGGCTGGAGTGCCCAATTCGTACCTACTTGGTG
ACAGCACGCAGTGCAGCCAGTTCCGGGGCCCGGGCTCTCAAGACCCTGCGCAGCTGGGGC
CTGGAGACAGATGAAGCCTTGTTCCTTGCTGGAGCGCCCAAGGGCCCTCTCCTTGAGAAG
ATCCGCCCACACATCTTCTTTGATGACCAGATGTTCCATGTGGCTGGGGCTCAGGAGATG
GGCACTGTGGCCGCCCATGTGCCTTATGGTGTGGCACAGACACCCCGGCGGACTGCACCT
GCAAAGCAGGCCCCATCTGCACAGTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF331801

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_4_Locus:
1p34.3-p33

# Metabolic_Enzyme_4_SNPs:
rs4660340; rs784611; rs752667; rs1180272; rs1180271; rs784595; rs873917; rs1568146; rs1535031; rs3851911; rs17264901; rs784596; rs12566856; rs12406284; rs11807200; rs784597; rs784610; rs734497; rs3806428; rs784600; rs11809004; rs7553293; rs3806433; rs16826428; rs9660121; rs784599; rs3806429; rs784612; rs1533479; rs2871601; rs41264507; rs34479837; rs12035327; rs1180270; rs9439008; rs35574502; rs34779558; rs36025518; rs36123767; rs35625235; rs28507686; rs35550484; rs11206573; rs41264509; rs784598; rs34604809; rs1535030; rs5773668; rs1517187; rs12039176; rs28592113; rs784594; rs9438930; rs11306359; rs35355327; rs6684666; rs34908371; rs28667717; rs3806432; rs5773667; rs7416372; rs34045723; rs6672154; rs35002774; rs35256759; rs3806431; rs12042601; rs10465833; rs1062103; rs10839; rs10888919; rs10888929; rs11206525; rs1180275; rs1180277; rs12039225; rs12042356; rs12565281; rs13315; rs16826440; rs17501838; rs17560858; rs2281302; rs2746057; rs3207766; rs3806434; rs3916165; rs6663003; rs6703320; rs704769; rs736009; rs7419080; rs784601; rs784602; rs784613; rs784615; rs784616; rs784627; rs784629; rs784630; rs813052

# Metabolic_Enzyme_4_General_References:
11133996

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5236

# Metabolic_Enzyme_5_Name:
5'(3')-deoxyribonucleotidase, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
5',3'-nucleotidase, mitochondrial; Deoxy-5'-nucleotidase 2; dNT-2

# Metabolic_Enzyme_5_Gene_Name:
NT5M

# Metabolic_Enzyme_5_Protein_Sequence:
>5'3'deoxyribonucleotidase, mitochondrial precursor
MIRLGGWCARRLCSAAVPAGRRGAAGGLGLAGGRALRVLVDMDGVLADFEGGFLRKFRAR
FPDQPFIALEDRRGFWVSEQYGRLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMAS
LQNTDVFICTSPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDI
TGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRPC

# Metabolic_Enzyme_5_Number_of_Residues:
228

# Metabolic_Enzyme_5_Molecular_Weight:
25862

# Metabolic_Enzyme_5_Theoretical_pI:
8.12

# Metabolic_Enzyme_5_GO_Classification:
Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP

# Metabolic_Enzyme_5_Pathway:
Not Available

# Metabolic_Enzyme_5_Reaction:
Not Available

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_5_Signals:
1-15

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_5_GenBank_ID_Protein:
9408106

# Metabolic_Enzyme_5_SwissProt_ID:
NT5M_HUMAN (Q9NPB1)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
NT5M

# Metabolic_Enzyme_5_Geneatlas_id:
NT5M

# Metabolic_Enzyme_5_hgnc_id:
HGNC:15769

# Metabolic_Enzyme_5_PDB_ID:
1Q92

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_5_Gene_Sequence:
>687 bp
ATGATCCGGCTGGGCGGCTGGTGTGCGCGGCGGCTCTGCAGCGCGGCGGTTCCCGCGGGG
CGGCGCGGGGCGGCGGGCGGGCTGGGCCTGGCGGGAGGCCGCGCCCTACGGGTGCTGGTG
GACATGGACGGCGTGCTGGCTGACTTCGAGGGCGGATTCCTCAGGAAGTTCCGCGCGCGC
TTTCCCGACCAGCCCTTCATCGCGCTGGAGGACCGGCGCGGCTTCTGGGTGTCGGAGCAG
TACGGCCGCCTGCGGCCAGGGCTGAGCGAGAAGGCCATCAGCATTTGGGAGTCAAAGAAT
TTCTTTTTTGAACTTGAGCCTCTGCCAGGGGCCGTGGAAGCTGTCAAGGAGATGGCCAGC
CTACAAAACACTGACGTCTTCATCTGCACAAGCCCCATCAAGATGTTCAAGTACTGTCCC
TATGAGAAGTATGCCTGGGTGGAGAAGTACTTTGGCCCTGACTTTCTGGAGCAGATTGTG
CTGACCAGAGACAAGACCGTGGTCTCTGCTGACCTTCTCATAGACGACCGGCCGGACATC
ACAGGGGCCGAGCCAACCCCCAGCTGGGAGCATGTCCTCTTCACCGCCTGCCACAACCAG
CACCTGCAGCTGCAGCCCCCCCGCCGCAGGCTGCACTCGTGGGCGGACGACTGGAAGGCC
ATTCTGGACAGCAAGCGGCCCTGCTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AJ277557

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_5_Locus:
17p11.2

# Metabolic_Enzyme_5_SNPs:
rs2240876; rs758742; rs1860553; rs242243; rs6502579; rs7223473; rs11078384; rs7226068; rs10468464; rs12948296; rs1860552; rs9912109; rs9898622; rs7211968; rs17726703; rs9914692; rs3785502; rs11867932; rs3785504; rs17726673; rs11654778; rs16942153; rs17726858; rs11078382; rs3826302; rs2064060; rs6502580; rs7217503; rs9912172; rs3785506; rs9908168; rs11652902; rs9902505; rs4985707; rs6502576; rs6502578; rs16961564; rs7210344; rs16961516; rs242242; rs171394; rs12600778; rs9909111; rs7219752; rs6502577; rs12601631; rs11869054; rs17726924; rs9891799; rs11870836; rs11869507; rs11078383; rs4985706; rs7217162; rs9889738; rs9908338; rs7222555; rs9915883; rs7211243; rs9916133; rs9907857; rs9905836; rs11657817; rs9889298; rs7220829; rs9903425; rs9908360; rs9914424; rs9908124; rs11650700; rs11869079; rs7212369; rs9889367; rs7217114; rs9896977; rs9916676; rs16961561; rs12602026; rs9896970; rs9904396; rs9909850; rs10852849; rs11078385; rs6502575; rs242244; rs16961576; rs3203918; rs8082383; rs7212012; rs36114962; rs9889834; rs7226045; rs12602003; rs9894669; rs35712658; rs12941075; rs7210625; rs35320589; rs11655849; rs35470335; rs34668117; rs12943271; rs34446504; rs35945070; rs34219219; rs12951176; rs35554631; rs34408375; rs28825184; rs7218566; rs35917484; rs28880443; rs9904393; rs12601106; rs34579357; rs4985765; rs9907711; rs11343472; rs35579933; rs3087093; rs12951985; rs34993127; rs36088408; rs36091965; rs34100977; rs7220057; rs8080335; rs9901325; rs35720826; rs34886391; rs12949216; rs9898993; rs34121330; rs34513135; rs12936127; rs8067236; rs8081939; rs10617184; rs7211790; rs9914209; rs12951519; rs12603230; rs9913775; rs8068408; rs12452455; rs9901373; rs3063349; rs9913682; rs3785503; rs34156759; rs34776810; rs10574223; rs34836173; rs12951434; rs9709057; rs28813401; rs36146846; rs34709982; rs28616155; rs8082379; rs35267848; rs12951289; rs12948357; rs12950577; rs35861887; rs12948747; rs35096596; rs8080408; rs9898042; rs35930947; rs12948751; rs5741757; rs9889355; rs35575792; rs34018072; rs34407368; rs4985764; rs11395505; rs34676851; rs12951504; rs12950929; rs34025151; rs3837806; rs34247865; rs12946386; rs34209605; rs7219953; rs12951983; rs11400183; rs9912599; rs36056059; rs8071972; rs35039203; rs35326975; rs8071718; rs12946113; rs1009720; rs10852850; rs11078381; rs11078386; rs11871699; rs12450758; rs12451886; rs12452946; rs12602578; rs16961593; rs16961599; rs17648393; rs183596; rs190261; rs2041393; rs2058292; rs2191383; rs242246; rs242247; rs242249; rs242250; rs242251; rs624242; rs6502572; rs8067390; rs9892592; rs9899615; rs9905458; rs9909800; rs9914113

# Metabolic_Enzyme_5_General_References:
10899995; 12352955

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5237

# Metabolic_Enzyme_6_Name:
Cytosolic purine 5'-nucleotidase

# Metabolic_Enzyme_6_Synonyms:
5'-nucleotidase cytosolic II

# Metabolic_Enzyme_6_Gene_Name:
NT5C2

# Metabolic_Enzyme_6_Protein_Sequence:
>Cytosolic purine 5'nucleotidase
MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVY
KSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLV
CAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTS
CETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMK
EVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGT
VLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKS
KKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQ
RRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAA
HVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLA
PQEITHCHDEDDDEEEEEEEE

# Metabolic_Enzyme_6_Number_of_Residues:
561

# Metabolic_Enzyme_6_Molecular_Weight:
64970

# Metabolic_Enzyme_6_Theoretical_pI:
6.05

# Metabolic_Enzyme_6_GO_Classification:
Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides

# Metabolic_Enzyme_6_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_6_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF05761:5_nucleotid

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_6_GenBank_ID_Protein:
633071

# Metabolic_Enzyme_6_SwissProt_ID:
5NTC_HUMAN (P49902)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
NT5C2

# Metabolic_Enzyme_6_Geneatlas_id:
NT5C2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:8022

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_6_Gene_Sequence:
>1686 bp
ATGTCGACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGAT
AAGCATGCCCTGAAAAAGTATCGTCGAGAAGCCTATCATCGGGTGTTTGTGAACCGAAGT
TTAGCAATGGAAAAGATAAAGTGTTTTGGTTTTGATATGGATTATACCCTTGCTGTGTAC
AAGTCCCCAGAGTATGAGTCCCTTGGTTTTGAGCTTACTGTGGAGAGATTAGTTTCTATT
GGCTATCCCCAGGAGTTGCTCAGCTTTGCTTATGATTCTACATTCCCTACCAGGGGACTT
GTCTTTGACACACTGTATGGAAATCTTTTGAAAGTCGATGCCTATGGAAACCTCTTGGTC
TGTGCACATGGATTTAACTTTATAAGGGGACCAGAAACTAGAGAACAGTATCCAAATAAA
TTTATCCAGCGAGATGATACTGAAAGATTTTACATTCTGAACACACTATTCAACCTACCA
GAGACCTACCTGTTGGCCTGCCTAGTAGATTTTTTTACTAATTGTCCCAGATATACCAGT
TGTGAAACAGGATTTAAAGATGGGGACCTCTTCATGTCCTACCGGAGTATGTTCCAGGAT
GTAAGAGATGCTGTTGACTGGGTTCATTACAAGGGCTCCCTTAAGGAAAAGACAGTTGAA
AATCTTGAGAAGTATGTAGTCAAAGATGGAAAACTGCCTTTGCTTCTGAGCCGGATGAAG
GAAGTAGGGAAAGTATTTCTTGCTACCAACAGTGACTATAAATATACAGATAAAATTATG
ACTTACCTGTTTGACTTCCCACATGGCCCCAAGCCTGGGAGCTCCCATCGACCATGGCAG
TCCTACTTTGACTTGATCTTGGTGGATGCACGGAAACCACTCTTTTTTGGAGAAGGCACA
GTACTGCGTCAGGTGGATACTAAAACTGGCAAGCTGAAAATTGGTACCTACACAGGGCCC
CTACAGCATGGTATCGTCTACTCAGGAGGTTCTTCTGATACGATCTGTGACCTGTTGGGA
GCCAAGGGAAAAGACATTTTGTATATTGGAGATCACATTTTTGGGGACATTTTAAAATCA
AAGAAACGGCAAGGGTGGCGAACTTTTTTGGTGATTCCTGAACTCGCACAGGAGCTACAT
GTCTGGACTGACAAGAGTTCACTTTTCGAAGAACTTCAGAGCTTGGATATTTTCTTGGCT
GAACTCTACAAGCATCTTGACAGCAGTAGCAATGAGCGTCCAGACATCAGTTCCATCCAG
AGACGTATTAAGAAAGTAACTCATGACATGGACATGTGCTATGGGATGATGGGAAGCCTG
TTTCGCAGTGGCTCCCGGCAGACCCTTTTTGCCAGTCAAGTGATGCGTTATGCTGACCTC
TATGCAGCATCTTTCATCAACCTGCTGTATTACCCTTTCAGCTACCTCTTCAGGGCTGCC
CATGTCTTGATGCCTCATGAATCAACGGTGGAGCACACACACGTAGATATCAATGAGATG
GAGTCTCCTCTTGCCACCCGGAACCGCACATCAGTGGATTTCAAAGACACTGACTACAAG
CGGCACCAGCTGACACGGTCAATTAGTGAGATTAAACCTCCCAACCTCTTCCCACTGGCC
CCCCAGGAAATTACACACTGCCATGACGAAGATGATGATGAAGAGGAGGAGGAGGAGGAA
GAATAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
D38524

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_6_Locus:
10q24.32-q24.33

# Metabolic_Enzyme_6_SNPs:
rs12262171; rs3740387; rs12253627; rs10786736; rs8139; rs7917650; rs10786741; rs7920251; rs10430665; rs7916854; rs12573199; rs11191598; rs1163238; rs12573200; rs10883843; rs7092407; rs12573221; rs4917997; rs11191593; rs11191596; rs10786744; rs1163236; rs10883842; rs10786742; rs10786743; rs7075552; rs7077097; rs2863728; rs3758543; rs7077291; rs10748838; rs3087681; rs12240508; rs732998; rs10883830; rs7899084; rs2274340; rs2182348; rs2066322; rs7908960; rs7912517; rs7067970; rs3740386; rs7896547; rs11191554; rs1163249; rs2281877; rs2863727; rs3781281; rs2274341; rs2148198; rs7897663; rs3781282; rs10883832; rs1926029; rs1935323; rs1926030; rs746293; rs6584539; rs2066323; rs9919482; rs3740385; rs12773916; rs12414232; rs10786737; rs12413046; rs12412038; rs2274339; rs11598702; rs1541213; rs11191580; rs11191553; rs10509765; rs10509766; rs3977751; rs12220375; rs4917996; rs7896433; rs6584540; rs1926037; rs3736922; rs11191577; rs2148197; rs11191561; rs7080935; rs11191555; rs10883833; rs12219304; rs1926036; rs7913920; rs10883834; rs11191558; rs11191582; rs11191589; rs10883831; rs12220743; rs10786738; rs11191560; rs10748837; rs11191578; rs3781280; rs7896519; rs12217501; rs11191573; rs7067741; rs6584541; rs7067663; rs2148200; rs10883840; rs11191583; rs12415199; rs9919485; rs11191557; rs17094683; rs7895154; rs12355120; rs2153774; rs10786739; rs7915816; rs7081075; rs1807298; rs3861984; rs11191572; rs12571568; rs12416331; rs11191586; rs10883839; rs12766205; rs1163239; rs10883837; rs11191584; rs1163247; rs17115452; rs11191556; rs7909022; rs12775302; rs9633712; rs11191581; rs11191576; rs10883836; rs11191549; rs7095304; rs10883845; rs11191550; rs11191548; rs11191602; rs10748839; rs1141101; rs1055812; rs1141100; rs1141098; rs1141099; rs34351688; rs34394526; rs34058246; rs11191594; rs35224704; rs34747231; rs12774207; rs11191595; rs34699185; rs11280184; rs1163237; rs7073259; rs34064597; rs11191601; rs35525740; rs35291480; rs12264098; rs35978588; rs12241986; rs7091462; rs12774182; rs34756486; rs35695488; rs12252236; rs3834416; rs11191600; rs34136949; rs7080242; rs12763243; rs34003851; rs11191585; rs11191551; rs36111455; rs34966121; rs35464534; rs35541240; rs11191571; rs35913488; rs34223002; rs11440429; rs41287482; rs35653865; rs34963818; rs11191559; rs11191568; rs35436872; rs17795366; rs1163246; rs34060908; rs34963563; rs34915846; rs12780509; rs2153773; rs34211645; rs3736924; rs34758128; rs36059537; rs35302704; rs12255989; rs34104646; rs11191574; rs11191564; rs35745742; rs34644789; rs5787481; rs34863357; rs11191590; rs12774840; rs2148196; rs12763944; rs3215816; rs34207290; rs35752695; rs34445719; rs28419708; rs4421684; rs28516969; rs12265498; rs12767422; rs12772228; rs34908445; rs11191570; rs17115449; rs35195396; rs12243923; rs10883835; rs12779263; rs11302933; rs7091173; rs11375439; rs7071103; rs35146429; rs35338839; rs34268365; rs34130454; rs35898850; rs3861983; rs28404041; rs35621207; rs3736923; rs5787482; rs7075048; rs34307431; rs35348020; rs34349473; rs1773930; rs11191566; rs34870452; rs35078544; rs35123178; rs12265545; rs1163241; rs3949893; rs7904067; rs12775841; rs35821867; rs12775904; rs7915032; rs5028036; rs35254502; rs1163248; rs35365027; rs34876862; rs11191565; rs12772280; rs10709724; rs35085852; rs35351555; rs12774513; rs10710371; rs11296588; rs12243903; rs28605898; rs34241930; rs34549427; rs11451961; rs34403968; rs12761657; rs34397864; rs3062737; rs36092020; rs35109679; rs34011916; rs34435560; rs11191562; rs4917383; rs34067380; rs34202831; rs11191563; rs2148199; rs34133379; rs35763505; rs12414385; rs1163240; rs12262258; rs11191588; rs34664715; rs12414374; rs35133717; rs3837340; rs10614009; rs2153772; rs11191587; rs11403586; rs11191575; rs1060240; rs34588165; rs11191552; rs41317254; rs1163245; rs1064099; rs12268552; rs34833988; rs11191603; rs12253716; rs12412924; rs3841710; rs34551510; rs12246784; rs12781668; rs1064098; rs10458729; rs10786740; rs10786745; rs10883829; rs10883841; rs11191547; rs1163235; rs12261294; rs12571345; rs12785223; rs17115427; rs4307650; rs4917382; rs4917995; rs7074395; rs7092200; rs726010; rs763914; rs7921996; rs943035

# Metabolic_Enzyme_6_General_References:
7999131

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5805

# Metabolic_Enzyme_7_Name:
Purine nucleoside phosphorylase

# Metabolic_Enzyme_7_Synonyms:
Inosine phosphorylase; PNP

# Metabolic_Enzyme_7_Gene_Name:
NP

# Metabolic_Enzyme_7_Protein_Sequence:
>Purine nucleoside phosphorylase
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS

# Metabolic_Enzyme_7_Number_of_Residues:
289

# Metabolic_Enzyme_7_Molecular_Weight:
32118

# Metabolic_Enzyme_7_Theoretical_pI:
6.95

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  purine-nucleoside phosphorylase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_7_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_7_Reaction:
purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00896:Mtap_PNP

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.4.2.1

# Metabolic_Enzyme_7_GenBank_ID_Protein:
35565

# Metabolic_Enzyme_7_SwissProt_ID:
PNPH_HUMAN (P00491)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
NP

# Metabolic_Enzyme_7_Geneatlas_id:
NP

# Metabolic_Enzyme_7_hgnc_id:
HGNC:7892

# Metabolic_Enzyme_7_PDB_ID:
1RT9

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>870 bp
ATGGAGAACGGATACACCTATGAAGATTATAAGAACACTGCAGAATGGCTTCTGTCTCAT
ACTAAGCACCGACCTCAAGTTGCAATAATCTGTGGTTCTGGATTAGGAGGTCTGACTGAT
AAATTAACTCAGGCCCAGATCTTTGACTACAGTGAAATCCCCAACTTTCCTCGAAGTACA
GTGCCAGGTCATGCTGGCCGACTGGTGTTTGGGTTCCTGAATGGCAGGGCCTGTGTGATG
ATGCAGGGCAGGTTCCACATGTATGAAGGGTACCCACTCTGGAAGGTGACATTCCCAGTG
AGGGTTTTCCACCTTCTGGGTGTGGACACCCTGGTAGTCACCAATGCAGCAGGAGGGCTG
AACCCCAAGTTTGAGGTTGGAGATATCATGCTGATCCGTGACCATATCAACCTACCTGGT
TTCAGTGGTCAGAACCCTCTCAGAGGGCCCAATGATGAAAGGTTTGGAGATCGTTTCCCT
GCCATGTCTGATGCCTACGACCGGACTATGAGGCAGAGGGCTCTCAGTACCTGGAAACAA
ATGGGGGAGCAACGTGAGCTACAGGAAGGCACCTATGTGATGGTGGCAGGCCCCAGCTTT
GAGACTGTGGCAGAATGTCGTGTGCTGCAGAAGCTGGGAGCAGACGCTGTTGGCATGAGT
ACAGTACCAGAAGTTATCGTTGCACGGCACTGTGGACTTCGAGTCTTTGGCTTCTCACTC
ATCACTAACAAGGTCATCATGGATTATGAAAGCCTGGAGAAGGCCAACCATGAAGAAGTC
TTAGCAGCTGGCAAACAAGCTGCACAGAAATTGGAACAGTTTGTCTCCATTCTTATGGCC
AGCATTCCACTCCCTGACAAAGCCAGTTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
X00737

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_7_Locus:
14q13.1

# Metabolic_Enzyme_7_SNPs:
rs1049564; rs1130650; rs1049562; rs7785; rs1617940; rs1760940; rs1713420; rs1760935; rs1713422; rs1713421; rs3790064; rs3790065; rs1713429; rs17882804; rs17880405; rs1756369; rs12147688; rs8008133; rs17881431; rs17881345; rs7154909; rs17883821; rs17885781; rs1760934; rs17879107; rs17880844; rs17879913; rs17881184; rs17885714; rs17880480; rs17883253; rs17878900; rs1713426; rs17881356; rs1713427; rs1760933; rs3790062; rs17883795; rs17112168; rs17880290; rs12147906; rs17881554; rs17881206; rs1049700; rs17882836; rs12101049; rs17884106; rs12147035; rs34480769; rs3838361; rs3842517; rs1760939; rs17885917; rs17886095; rs1760938; rs17883294; rs17883604; rs8019880; rs17881280; rs35549071; rs35139440; rs17880503; rs7151666; rs10498268; rs1079375; rs1079376; rs11846743; rs11850059; rs11850069; rs12587218; rs12886203; rs12888804; rs12891271; rs13379232; rs13379234; rs1629478; rs17112384; rs17112385; rs1713459; rs1713460; rs1713461; rs1713462; rs17242655; rs17242662; rs17242669; rs1756365; rs1760930; rs1760931; rs1760941; rs1760942; rs2077153; rs2481768; rs35175606; rs35567022; rs7156659; rs755777

# Metabolic_Enzyme_7_General_References:
6087295; 3029074; 12928150; 2104852; 1384322; 8931706

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5229

# Metabolic_Enzyme_8_Name:
5'-nucleotidase precursor

# Metabolic_Enzyme_8_Synonyms:
Ecto-5'-nucleotidase; 5'-NT; CD73 antigen

# Metabolic_Enzyme_8_Gene_Name:
NT5E

# Metabolic_Enzyme_8_Protein_Sequence:
>5'nucleotidase precursor
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ

# Metabolic_Enzyme_8_Number_of_Residues:
574

# Metabolic_Enzyme_8_Molecular_Weight:
63368

# Metabolic_Enzyme_8_Theoretical_pI:
7.04

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  hydrolase activity, acting on ester bonds
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides

# Metabolic_Enzyme_8_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_8_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF02872:5_nucleotid_C;
PF00149:Metallophos

# Metabolic_Enzyme_8_Signals:
1-26

# Metabolic_Enzyme_8_Transmembrane_Regions:
556-573

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_8_GenBank_ID_Protein:
23897

# Metabolic_Enzyme_8_SwissProt_ID:
5NTD_HUMAN (P21589)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
NT5E

# Metabolic_Enzyme_8_Geneatlas_id:
NT5E

# Metabolic_Enzyme_8_hgnc_id:
HGNC:8021

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Metabolic_Enzyme_8_Gene_Sequence:
>1725 bp
ATGTGTCCCCGAGCCGCGCGGGCGCCCGCGACGCTACTCCTCGCCCTGGGCGCGGTGCTG
TGGCCTGCGGCTGGCGCCTGGGAGCTTACGATTTTGCACACCAACGACGTGCACAGCCGG
CTGGAGCAGACCAGCGAGGACTCCAGCAAGTGCGTCAACGCCAGCCGCTGCATGGGTGGC
GTGGCTCGGCTCTTCACCAAGGTTCAGCAGATCCGCCGCGCCGAACCCAACGTGCTGCTG
CTGGACGCCGGCGACCAGTACCAGGGCACTATCTGGTTCACCGTGTACAAGGGCGCCGAG
GTGGCGCACTTCATGAACGCCCTGCGCTACGATGCCATGGCACTGGGAAATCATGAATTT
GATAATGGTGTGGAAGGACTGATCGAGCCACTCCTCAAAGAGGCCAAATTTCCAATTCTG
AGTGCAAACATTAAAGCAAAGGGGCCACTAGCATCTCAAATATCAGGACTTTATTTGCCA
TATAAAGTTCTTCCTGTTGGTGATGAAGTTGTGGGAATCGTTGGATACACTTCCAAAGAA
ACCCCTTTTCTCTCAAATCCAGGGACAAATTTAGTGTTTGAAGATGAAATCACTGCATTA
CAACCTGAAGTAGATAAGTTAAAAACTCTAAATGTGAACAAAATTATTGCACTGGGACAT
TCGGGTTTTGAAATGGATAAACTCATCGCTCAGAAAGTGAGGGGTGTGGACGTCGTGGTG
GGAGGACACTCCAACACATTTCTTTACACAGGCAATCCACCTTCCAAAGAGGTGCCTGCT
GGGAAGTACCCATTCATAGTCACTTCTGATGATGGGCGGAAGGTTCCTGTAGTCCAGGCC
TATGCTTTTGGCAAATACCTAGGCTATCTGAAGATCGAGTTTGATGAAAGAGGAAACGTC
ATCTCTTCCCATGGAAATCCCATTCTTCTAAACAGCAGCATTCCTGAAGATCCAAGCATA
AAAGCAGACATTAACAAATGGAGGATAAAATTGGATAATTATTCTACCCAGGAATTAGGG
AAAACAATTGTCTATCTGGATGGCTCCTCTCAATCATGCCGCTTTAGAGAATGCAACATG
GGCAACCTGATTTGTGATGCAATGATTAACAACAACCTGAGACACACGGATGAAATGTTC
TGGAACCACGTATCCATGTGCATTTTAAATGGAGGTGGTATCCGGTCGCCCATTGATGAA
CGCAACAATGGCACAATTACCTGGGAGAACCTGGCTGCTGTATTGCCCTTTGGAGGCACA
TTTGACCTAGTCCAGTTAAAAGGTTCCACCCTGAAGAAGGCCTTTGAGCATAGCGTGCAC
CGCTACGGCCAGTCCACTGGAGAGTTCCTGCAGGTGGGCGGAATCCATGTGGTGTATGAT
CTTTCCCGAAAACCTGGAGACAGAGTAGTCAAATTAGATGTTCTTTGCACCAAGTGTCGA
GTGCCCAGTTATGACCCTCTCAAAATGGACGAGGTATATAAGGTGATCCTCCCAAACTTC
CTGGCCAATGGTGGAGATGGGTTCCAGATGATAAAAGATGAATTATTAAGACATGACTCT
GGTGACCAAGATATCAACGTGGTTTCTACATATATCTCCAAAATGAAAGTAATTTATCCA
GCAGTTGAAGGTCGGATCAAGTTTTCCACAGGAAGTCACTGCCATGGAAGCTTTTCTTTA
ATATTTCTTTCACTTTGGGCAGTGATCTTTGTTTTATACCAATAG

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X55740

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_8_Locus:
6q14-q21

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
2129526; 8566797; 2173922; 9651114

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
6043

# Metabolic_Enzyme_9_Name:
Deoxyguanosine kinase, mitochondrial precursor

# Metabolic_Enzyme_9_Synonyms:
dGK

# Metabolic_Enzyme_9_Gene_Name:
DGUOK

# Metabolic_Enzyme_9_Protein_Sequence:
>Deoxyguanosine kinase, mitochondrial precursor
MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK
TYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLK
VQLEPFPEKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEF
ASRITLHGFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFE
ALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL

# Metabolic_Enzyme_9_Number_of_Residues:
277

# Metabolic_Enzyme_9_Molecular_Weight:
32056

# Metabolic_Enzyme_9_Theoretical_pI:
8.97

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents

# Metabolic_Enzyme_9_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_9_Reaction:
ATP + deoxyguanosine = ADP + dGMP

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF01712:dNK

# Metabolic_Enzyme_9_Signals:
1-19

# Metabolic_Enzyme_9_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.7.1.113

# Metabolic_Enzyme_9_GenBank_ID_Protein:
1477482

# Metabolic_Enzyme_9_SwissProt_ID:
DGUOK_HUMAN (Q16854)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
DGUOK

# Metabolic_Enzyme_9_Geneatlas_id:
DGUOK

# Metabolic_Enzyme_9_hgnc_id:
HGNC:2858

# Metabolic_Enzyme_9_PDB_ID:
1JAG

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_9_Gene_Sequence:
>834 bp
ATGGCCGCGGGCCGCCTCTTTCTAAGTCGGCTTCGAGCACCCTTCAGTTCCATGGCCAAG
AGCCCACTCGAGGGCGTTTCCTCCTCCAGAGGCCTGCACGCGGGGCGCGGGCCCCGAAGG
CTCTCCATCGAAGGCAACATTGCTGTGGGAAAGTCCACGTTTGTGAAGTTACTCACGAAA
ACTTACCCAGAATGGCACGTAGCTACAGAACCTGTAGCAACATGGCAGAATATCCAGGCT
GCTGGCAACCAAAAAGCCTGCACTGCCCAAAGTCTTGGAAACTTGCTGGATATGATGTAC
CGGGAGCCAGCACGATGGTCCTACACATTCCAGACATTTTCCTTTTTGAGCCGCCTGAAA
GTACAGCTGGAGCCCTTCCCTGAGAAACTCTTACAGGCCAGGAAGCCAGTACAGATCTTT
GAGAGGTCTGTGTACAGTGACAGGTATATCTTTGCAAAGAATCTTTTTGAAAATGGTTCC
CTCAGTGACATCGAGTGGCATATCTATCAGGACTGGCATTCTTTTCTCCTGTGGGAGTTT
GCCAGCCGGATCACATTACATGGCTTCATCTACCTCCAGGCTTCTCCCCAGGTTTGTTTG
AAGAGACTGTACCAGAGGGCCAGGGAGGAGGAGAAAGGAATTGAGCTGGCCTATCTAGAG
CAGCTGCATGGCCAACACGAAGCCTGGCTTATTCACAAGACAACGAAGCTCCACTTTGAG
GCTCTGATGAACATTCCAGTGCTGGTGTTGGATGTCAATGATGATTTTTCTGAGGAAGTA
ACCAAACAAGAAGACCTCATGAGAGAGGTAAACACCTTTGTAAAGAATCTGTAA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
U41668

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_9_Locus:
2p13

# Metabolic_Enzyme_9_SNPs:
rs4777; rs10186730; rs1464690; rs831528; rs2243819; rs1464691; rs831527; rs831529; rs940299; rs2462124; rs831547; rs6737156; rs4852323; rs831550; rs940301; rs7564379; rs4852322; rs4852994; rs2002711; rs6725492; rs2694701; rs1464688; rs4077241; rs6747283; rs940298; rs2248050; rs940300; rs7557705; rs7562212; rs7558578; rs7601739; rs6546879; rs13404298; rs12470578; rs1523828; rs7606862; rs1096555; rs17009506; rs12621357; rs1464689; rs831548; rs940297; rs7565288; rs2254678; rs2243800; rs6744909; rs831549; rs2689773; rs1721260; rs6546878; rs13403888; rs11677402; rs13408733; rs831545; rs2244751; rs831524; rs11683738; rs831525; rs7568036; rs7581995; rs1721250; rs11892561; rs7567788; rs831526; rs7581999; rs7567810; rs7594405; rs7567878; rs1721251; rs7567676; rs11542976; rs1804599; rs35404246; rs10613860; rs5026865; rs35945580; rs6722482; rs35831031; rs10701633; rs13429684; rs28382406; rs4583496; rs831546; rs34850716; rs35711791; rs10573977; rs7567651; rs11306613; rs35377999; rs11884185; rs1916728; rs11357008; rs11279058; rs12329037; rs34633950; rs35726521; rs6747191; rs10585795; rs36107071; rs35979524; rs7559892; rs35066561; rs2462125; rs11342540; rs35486896; rs1726030; rs35831103; rs34963678; rs35885614; rs11327543; rs1721249; rs35616451; rs3841268; rs35826941; rs10195831; rs10196755; rs10201881; rs11126423; rs11892766; rs13387666; rs13391084; rs13397340; rs13411881; rs1622752; rs1623605; rs1653249; rs1653250; rs1653251; rs1653252; rs17009488; rs1721238; rs1726028; rs3923991; rs4530395; rs6747927; rs7570375; rs7598248; rs831522; rs831523; rs951408; rs951409

# Metabolic_Enzyme_9_General_References:
8692979; 8706825

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
6080

# Metabolic_Enzyme_10_Name:
Transketolase-like protein 1

# Metabolic_Enzyme_10_Synonyms:
Transketolase 2; TK 2; Transketolase-related protein

# Metabolic_Enzyme_10_Gene_Name:
TKTL1

# Metabolic_Enzyme_10_Protein_Sequence:
>Transketolaselike protein 1
MADAEARAEFPEEARPDRGTLQVLQDMASRLRIHSIRATCSTSSGHPTSCSSSSEIMSVL
FFYIMRYKQSDPENPDNDRFVLAKRLSFVDVATGWLGQGLGVACGMAYTGKYFDRASYRV
FCLMSDGESSEGSVWEAMAFASYYSLDNLVAIFDVNRLGHSGALPAEHCINIYQRRCEAF
GWNTYVVDGRDVEALCQVFWQASQVKHKPTAVVAKTFKGRGTPSIEDAESWHAKPMPRER
ADAIIKLIESQIQTSRNLDPQPPIEDSPEVNITDVRMTSPPDYRVGDKIATRKACGLALA
KLGYANNRVVVLDGDTRYSTFSEIFNKEYPERFIECFMAEQNMVSVALGCASRGRTIAFA
STFAAFLTRAFDHIRIGGLAESNINIIGSHCGVSVGDDGASQMALEDIAMFRTIPKCTIF
YPTDAVSTEHAVALAANAKGMCFIRTTRPETMVIYTPQERFEIGQAKVLRHCVSDKVTVI
GAGITVYEALAAADELSKQDIFIRVIDLFTIKPLDVATIVSSAKATEGRIITVEDHYPQG
GIGEAVCAAVSMDPDIQVHSLAVSGVPQSGKSEELLDMYGISARHIIVAVKCMLLN

# Metabolic_Enzyme_10_Number_of_Residues:
596

# Metabolic_Enzyme_10_Molecular_Weight:
65334

# Metabolic_Enzyme_10_Theoretical_pI:
5.65

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring aldehyde or ketonic groups
Function:  transketolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_10_Specific_Function:
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

# Metabolic_Enzyme_10_Pathway:
map00030  Pentose phosphate pathway;
 map00710  Carbon fixation;
 map01051  Biosynthesis of ansamycins

# Metabolic_Enzyme_10_Reaction:
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF02779:Transket_pyr;
PF02780:Transketolase_C;
PF00456:Transketolase_N

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.2.1.1

# Metabolic_Enzyme_10_GenBank_ID_Protein:
1232175

# Metabolic_Enzyme_10_SwissProt_ID:
TKTL1_HUMAN (P51854)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
TKTL1

# Metabolic_Enzyme_10_Geneatlas_id:
TKTL1

# Metabolic_Enzyme_10_hgnc_id:
HGNC:11835

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic and to a lesser extent also nuclear

# Metabolic_Enzyme_10_Gene_Sequence:
>1623 bp
ATGTCTGTGCTGTTCTTCTACATCATGAGGTACAAGCAGTCAGATCCAGAGAATCCGGAC
AACGACCGATTTGTCCTCGCAAAGAGACTGTCGTTTGTGGATGTGGCAACAGGATGGCTC
GGACAAGGACTGGGAGTTGCATGTGGAATGGCATATACTGGCAAGTACTTCGACAGGGCC
AGCTACCGGGTGTTCTGCCTCATGAGTGATGGCGAGTCCTCAGAAGGCTCTGTCTGGGAG
GCAATGGCCTTTGCTTCCTACTACAGTCTGGACAATCTTGTGGCAATCTTTGATGTGAAC
CGCCTGGGACACAGTGGTGCATTGCCCGCCGAGCACTGCATAAACATCTATCAGAGGCGC
TGCGAAGCCTTTGGGTGGAACACTTATGTGGTGGACGGCCGGGACGTGGAGGCACTGTGC
CAGGTATTCTGGCAGGCTTCTCAGGTGAAGCACAAGCCCACTGCTGTGGTGGCCAAGACC
TTCAAGGGCCGGGGCACCCCAAGTATTGAGGATGCAGAAAGTTGGCATGCAAAGCCAATG
CCGAGAGAAAGAGCAGATGCCATTATCAAATTAATTGAGAGCCAGATACAGACCAGCAGG
AATCTTGACCCACAGCCCCCCATTGAGGACTCACCTGAAGTCAACATCACAGATGTAAGG
ATGACCTCTCCACCTGATTACAGAGTTGGTGACAAGATAGCTACTCGGAAAGCATGCGGT
CTGGCTCTGGCTAAGCTGGGCTACGCGAACAACAGAGTCGTTGTGCTGGATGGTGACACC
AGGTACTCTACTTTCTCTGAGATATTCAACAAGGAGTACCCTGAGCGCTTCATCGAGTGC
TTTATGGCTGAACAAAACATGGTGAGCGTGGCTCTGGGCTGTGCCTCCCGTGGACGGACC
ATTGCTTTTGCTAGCACCTTTGCTGCCTTTCTGACTCGAGCATTTGATCACATCCGGATA
GGAGGCCTCGCTGAGAGCAACATCAACATTATTGGTTCCCACTGTGGGGTATCTGTTGGT
GACGATGGTGCTTCCCAGATGGCCCTGGAGGATATAGCCATGTTCCGAACCATTCCCAAG
TGCACGATCTTCTACCCAACTGATGCCGTCTCCACGGAGCATGCTGTTGCTCTGGCAGCC
AATGCCAAGGGGATGTGCTTCATTCGGACCACCCGACCAGAAACTATGGTTATTTACACC
CCACAAGAACGCTTTGAGATCGGACAGGCCAAGGTCCTCCGCCACTGTGTCAGTGACAAG
GTCACAGTTATTGGAGCTGGAATTACTGTGTATGAAGCCTTAGCAGCTGCTGATGAGCTT
TCGAAACAAGATATTTTTATCCGTGTCATCGACCTGTTTACCATTAAACCTCTGGATGTC
GCCACCATCGTCTCCAGTGCAAAAGCCACAGAGGGCCGGATCATTACAGTGGAGGATCAC
TACCCGCAAGGTGGCATCGGGGAAGCTGTCTGCGCAGCCGTCTCCATGGATCCTGACATT
CAGGTTCATTCGCTGGCAGTGTCGGGAGTGCCCCAGAGTGGGAAGTCCGAGGAATTGCTG
GATATGTATGGAATTAGTGCCAGACATATCATAGTGGCCGTGAAATGCATGTTGCTGAAC
TAA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
X91817

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_10_Locus:
Xq28

# Metabolic_Enzyme_10_SNPs:
rs17174296; rs2872817; rs12010971; rs12014497; rs17336725; rs17091217; rs766419; rs2239467; rs5987244; rs5987245; rs5987246; rs2315056; rs766420; rs5987242; rs17336718; rs2239466; rs7882247; rs5986968; rs2266894; rs2283761; rs5987237; rs2239468; rs4898475; rs12559330; rs10126322; rs12012047; rs5987241; rs4898474; rs5986969; rs6655282; rs5987239; rs12558211; rs11796895; rs6643842; rs17281251; rs12556555; rs17852259; rs34204897; rs11541774; rs12687689; rs2283759; rs12384846; rs11796894; rs35220504; rs11390439; rs12834363; rs12861292; rs11388137; rs4272554; rs5904383; rs6643844; rs34305192; rs12858825; rs7059658; rs766418; rs7054539; rs11444073; rs12832683; rs4898378; rs12848002; rs5986970; rs5987243; rs6571309; rs7878511; rs2266893; rs33991397; rs12688821; rs6655280; rs5987240; rs35018687; rs34229834; rs10602804; rs6655279; rs34910176; rs34278084; rs2283760; rs5987238; rs5945410; rs6655281; rs3056971; rs12390625; rs17091374; rs17091376; rs17091380; rs5945412; rs5945413; rs6643845; rs6655283

# Metabolic_Enzyme_10_General_References:
8838793

# Metabolic_Enzyme_10_References:
11687801

# Macromolecular_Interacting_Partner_1_ID:
8267

# Macromolecular_Interacting_Partner_1_Name:
Toll-like receptor 9 precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
CD289 antigen

# Macromolecular_Interacting_Partner_1_Gene_Name:
TLR9

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Tolllike receptor 9 precursor
MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAA
PRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFL
AVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYY
KNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDL
ANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLN
ASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSF
GSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV
DLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLS
RNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHS
FTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSL
RALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRL
RDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGF
FSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAA
VPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCG
WDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRG
RWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLE
DRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHF
YNRNFCQGPTAE

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
1032

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
115861

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
8.23

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Participates in the innate immune response to microbial agents. Detects the unmethylated cytidine-phosphate-guanosine (CpG) motifs present in bacterial DNA. Acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00560:LRR_1;
PF01582:TIR

# Macromolecular_Interacting_Partner_1_Signals:
1-25

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
819-839

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
8099652

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
TLR9_HUMAN (Q9NR96)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
TLR9

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
TLR9

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:15633

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>3099 bp
ATGGGTTTCTGCCGCAGCGCCCTGCACCCGCTGTCTCTCCTGGTGCAGGCCATCATGCTG
GCCATGACCCTGGCCCTGGGTACCTTGCCTGCCTTCCTACCCTGTGAGCTCCAGCCCCAC
GGCCTGGTGAACTGCAACTGGCTGTTCCTGAAGTCTGTGCCCCACTTCTCCATGGCAGCA
CCCCGTGGCAATGTCACCAGCCTTTCCTTGTCCTCCAACCGCATCCACCACCTCCATGAT
TCTGACTTTGCCCACCTGCCCAGCCTGCGGCATCTCAACCTCAAGTGGAACTGCCCGCCG
GTTGGCCTCAGCCCCATGCACTTCCCCTGCCACATGACCATCGAGCCCAGCACCTTCTTG
GCTGTGCCCACCCTGGAAGAGCTAAACCTGAGCTACAACAACATCATGACTGTGCCTGCG
CTGCCCAAATCCCTCATATCCCTGTCCCTCAGCCATACCAACATCCTGATGCTAGACTCT
GCCAGCCTCGCCGGCCTGCATGCCCTGCGCTTCCTATTCATGGACGGCAACTGTTATTAC
AAGAACCCCTGCAGGCAGGCACTGGAGGTGGCCCCGGGTGCCCTCCTTGGCCTGGGCAAC
CTCACCCACCTGTCACTCAAGTACAACAACCTCACTGTGGTGCCCCGCAACCTGCCTTCC
AGCCTGGAGTATCTGCTGTTGTCCTACAACCGCATCGTCAAACTGGCGCCTGAGGACCTG
GCCAATCTGACCGCCCTGCGTGTGCTCGATGTGGGCGGAAATTGCCGCCGCTGCGACCAC
GCTCCCAACCCCTGCATGGAGTGCCCTCGTCACTTCCCCCAGCTACATCCCGATACCTTC
AGCCACCTGAGCCGTCTTGAAGGCCTGGTGTTGAAGGACAGTTCTCTCTCCTGGCTGAAT
GCCAGTTGGTTCCGTGGGCTGGGAAACCTCCGAGTGCTGGACCTGAGTGAGAACTTCCTC
TACAAATGCATCACTAAAACCAAGGCCTTCCAGGGCCTAACACAGCTGCGCAAGCTTAAC
CTGTCCTTCAATTACCAAAAGAGGGTGTCCTTTGCCCACCTGTCTCTGGCCCCTTCCTTC
GGGAGCCTGGTCGCCCTGAAGGAGCTGGACATGCACGGCATCTTCTTCCGCTCACTCGAT
GAGACCACGCTCCGGCCACTGGCCCGCCTGCCCATGCTCCAGACTCTGCGTCTGCAGATG
AACTTCATCAACCAGGCCCAGCTCGGCATCTTCAGGGCCTTCCCTGGCCTGCGCTACGTG
GACCTGTCGGACAACCGCATCAGCGGAGCTTCGGAGCTGACAGCCACCATGGGGGAGGCA
GATGGAGGGGAGAAGGTCTGGCTGCAGCCTGGGGACCTTGCTCCGGCCCCAGTGGACACT
CCCAGCTCTGAAGACTTCAGGCCCAACTGCAGCACCCTCAACTTCACCTTGGATCTGTCA
CGGAACAACCTGGTGACCGTGCAGCCGGAGATGTTTGCCCAGCTCTCGCACCTGCAGTGC
CTGCGCCTGAGCCACAACTGCATCTCGCAGGCAGTCAATGGCTCCCAGTTCCTGCCGCTG
ACCGGTCTGCAGGTGCTAGACCTGTCCCACAATAAGCTGGACCTCTACCACGAGCACTCA
TTCACGGAGCTACCACGACTGGAGGCCCTGGACCTCAGCTACAACAGCCAGCCCTTTGGC
ATGCAGGGCGTGGGCCACAACTTCAGCTTCGTGGCTCACCTGCGCACCCTGCGCCACCTC
AGCCTGGCCCACAACAACATCCACAGCCAAGTGTCCCAGCAGCTCTGCAGTACGTCGCTG
CGGGCCCTGGACTTCAGCGGCAATGCACTGGGCCATATGTGGGCCGAGGGAGACCTCTAT
CTGCACTTCTTCCAAGGCCTGAGCGGTTTGATCTGGCTGGACTTGTCCCAGAACCGCCTG
CACACCCTCCTGCCCCAAACCCTGCGCAACCTCCCCAAGAGCCTACAGGTGCTGCGTCTC
CGTGACAATTACCTGGCCTTCTTTAAGTGGTGGAGCCTCCACTTCCTGCCCAAACTGGAA
GTCCTCGACCTGGCAGGAAACCAGCTGAAGGCCCTGACCAATGGCAGCCTGCCTGCTGGC
ACCCGGCTCCGGAGGCTGGATGTCAGCTGCAACAGCATCAGCTTCGTGGCCCCCGGCTTC
TTTTCCAAGGCCAAGGAGCTGCGAGAGCTCAACCTTAGCGCCAACGCCCTCAAGACAGTG
GACCACTCCTGGTTTGGGCCCCTGGCGAGTGCCCTGCAAATACTAGATGTAAGCGCCAAC
CCTCTGCACTGCGCCTGTGGGGCGGCCTTTATGGACTTCCTGCTGGAGGTGCAGGCTGCC
GTGCCCGGTCTGCCCAGCCGGGTGAAGTGTGGCAGTCCGGGCCAGCTCCAGGGCCTCAGC
ATCTTTGCACAGGACCTGCGCCTCTGCCTGGATGAGGCCCTCTCCTGGGACTGTTTCGCC
CTCTCGCTGCTGGCTGTGGCTCTGGGCCTGGGTGTGCCCATGCTGCATCACCTCTGTGGC
TGGGACCTCTGGTACTGCTTCCACCTGTGCCTGGCCTGGCTTCCCTGGCGGGGGCGGCAA
AGTGGGCGAGATGAGGATGCCCTGCCCTACGATGCCTTCGTGGTCTTCGACAAAACGCAG
AGCGCAGTGGCAGACTGGGTGTACAACGAGCTTCGGGGGCAGCTGGAGGAGTGCCGTGGG
CGCTGGGCACTCCGCCTGTGCCTGGAGGAACGCGACTGGCTGCCTGGCAAAACCCTCTTT
GAGAACCTGTGGGCCTCGGTCTATGGCAGCCGCAAGACGCTGTTTGTGCTGGCCCACACG
GACCGGGTCAGTGGTCTCTTGCGCGCCAGCTTCCTGCTGGCCCAGCAGCGCCTGCTGGAG
GACCGCAAGGACGTCGTGGTGCTGGTGATCCTGAGCCCTGACGGCCGCCGCTCCCGCTAC
GTGCGGCTGCGCCAGCGCCTCTGCCGCCAGAGTGTCCTCCTCTGGCCCCACCAGCCCAGT
GGTCAGCGCAGCTTCTGGGCCCAGCTGGGCATGGCCCTGACCAGGGACAACCACCACTTC
TATAACCGGAACTTCTGCCAGGGACCCACGGCCGAATAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AF259262

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_1_Locus:
3p21.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs5743845; rs5743842; rs352140; rs5743848; rs5743847; rs352139; rs352144; rs5743839; rs187084; rs5743838; rs5743836; rs5743849; rs5743840; rs41308230; rs5743846; rs5743843; rs35147114; rs34399053; rs17846009; rs5743844; rs35133926; rs35654187; rs445676; rs35342983; rs41302828; rs5743841; rs3774413; rs13080616; rs36205003; rs13060808; rs5743850; rs34290056; rs5743837; rs6809796; rs34830597; rs5743835; rs3755812; rs34970647; rs35369972; rs10212560; rs11713464; rs11714313; rs11715382; rs11717574; rs11923172; rs12629425; rs164636; rs164637; rs164640; rs17052020; rs34008749; rs34038856; rs34450753; rs352141; rs352142; rs352143; rs352162; rs352163; rs352164; rs353545; rs353546; rs353547; rs353548; rs3733066; rs641606; rs7614535; rs9813448

# Macromolecular_Interacting_Partner_1_General_References:
11022119; 11022120; 11130078; 12975309; 11564765

# Macromolecular_Interacting_Partner_1_References:
14971051; 15218053

End of HMDB00085

Beginning of HMDB00086
# Accession_No:
HMDB00086

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-10 13:42:17

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Glycerophosphocholine

# Description:
Glycerophosphorylcholine is a phosphatidylcholine (lecithin) derivative in which the two hydroxy groups of GLYCEROL are esterified with fatty acids.  Glycerophosphorylcholine is one of the four major organic osmolytes in renal medullary cells, changing their intracellular osmolyte concentration in parallel with extracellular tonicity during cellular osmoadaptation. As an osmolyte, Glycerophosphorylcholine counteracts the effects of urea on enzymes and other macromolecules.  Kidneys (especially medullar cells), which are exposed under normal physiological conditions to widely fluctuating extracellular solute concentrations, respond to hypertonic stress by accumulating the organic osmolytes glycerophosphorylcholine (GPC), betaine, myo-inositol, sorbitol and free amino acids. Increased intracellular contents of these osmolytes are achieved by a combination of increased uptake (myo-inositol and betaine) and synthesis (sorbitol, GPC), decreased degradation (GPC) and reduced osmolyte release.

# Synonyms:
2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt; Choline Alfoscerate; Choline glycerophosphate; Glycerol 3-phosphocholine; Glycerol phosphorylcholine; Glycerol-3-phosphatidylcholine; Glycerophosphatidylcholine; Glycerophosphocholine; Glycerophosphorylcholine; L-Choline hydroxide 2,3-dihydroxypropyl hydrogen phosphate inner salt; L-alpha-Glycerophosphocholine; L-alpha-Glycerophosphorylcholine; L-alpha-Glycerylphosphorylcholine; a-Glycerophosphorylcholine; a-Glycerylphosphorylcholine; alpha-Glycerophosphorylcholine; hydrogen glycerophosphate Choline; sn-Glycero-3-phosphocholine; alpha-Glycerylphosphorylcholine

# Chemical_IUPAC_Name:
2-[[(2R)-2,3-dihydroxypropoxy]-hydroxy-phosphoryl]oxyethyl-trimethyl-azanium

# Chemical_Formula:
C8H20NO6P

# Chemical_Structure:
tbl_chemical:::HMDB00086_ZOOM.png:::119283181909566654

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00086_THUMB.png:::119283181711088660

# Taxonomy_Kingdom:
Organic Salt

# Taxonomy_Class:
Phosphoesters

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
cation; primary alcohol; secondary alcohol; 1,2-diol; quaternary ammonium salt; phosphoric acid ester

# Taxonomy_Biofunction:
Component of Glycerophospholipid metabolism; Component of Prostaglandin and leukotriene metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
257.10281

# Molecular_Weight_Avg:
257.22125

# Smiles_String_isomeric:
C[N+](C)(C)CCOP([O-])(=O)OC[C@@H](O)CO

# Smiles_String_canonical:
C[N+](C)(C)CCOP([O-])(=O)OCC(O)CO

# KEGG_Compound_ID:
C00670

# BioCyc_ID:
GLYCERYLPHOSPHORYLCHOLINE

# PubChem_CID:
439285

# PubChem_SID:
8026608; 8145747; 7886583; 3939

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
35659

# Wikipedia_ID:
Not Available

# METLIN_ID:
370

# Ref_ID:
9326834; 15465626; 15546701; 2347393; 15936878; 1663712; 2827914; 2150771; 15672550; 2817347; 1311847; 2002884; 12203225; 15516334; 10407117; 7857969

# ChEBI_ID:
16870

# CAS_Registry_Number:
28319-77-9

# InChI:
InChI=1/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/t8-/m0/s1

# Synthesis_Reference:
 Carbohydrate Research  (2004),  339(3),  461-468.

# Melting_Point:
142.5 oC

# Melting_Point_predicted:
48.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
1000.0 mg/mL [MEYLAN,WM et al. (1996)]; 8.96 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.55 [Predicted by ALOGPS]; -5.15 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00086_msds.pdf:::1132562198386445745

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::D-Glycerolphosphocholine.mol:::1132723806203794052

# SDF_File_[Text]:
tbl_chemical:::HMDB00086.sdf:::119283181353647113

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00086.pdb:::119283181570785732

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::060901_P00_17_IS_1DP_noesy.png:::116890067316567203287

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::060901_P00_17_IS_1DP_presat.zip:::1177710654311909294

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::060901_P00_17_IS_1DP_Assigned.png:::116864134491449072

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::060901_P00_17_IS_2DHSQC_1629.png:::116380886929481940

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::060901_P00_17_IS_2DHSQC_1629.zip:::116380886931111640

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::Glycerophosphocholine (HMDB00086).png:::117347358108277642

# Predicted_H_NMR_Spectrum:
tbl_chemical:::D-Glycerolphosphocholine.gif:::1132732106781398739

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00086_peaks.txt:::1156309535869233968

# Predicted_C_NMR_Spectrum:
tbl_chemical:::D-Glycerolphosphocholine_C.gif:::1132737678808416171

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00086_peaks.txt:::115631072618143924

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; Extracellular

# Tissue_Location:
Brain; Kidneys; Most Other Tissues; Spleen

# deuterated:
No

# Biofluid_Location:
Blood; Breast Milk; CSF; Semen

# Concentration_[Normal]:
Cerebrospinal_Fluid(CSF)	3.94 +/- 1.17	umol/L	Adult:>18_yrs_old	N/A	Normal	15465626
Cerebrospinal_Fluid(CSF)	3.9 +/- 1.2 	umol/L	Adult:>18_yrs_old	Both	Normal	15465626
Breast_Milk	362 +/- 70	uM	Adult:>18_yrs_old	N/A	Normal	8839502 
Semen	2.5 +/- 1.6	uM	Adult:>18_yrs_old	Both	Normal	2827914


# Concentration_[Abnormal]:
Cerebrospinal_Fluid(CSF)	4.03 +/- 1.52	umol/L	Elderly:>65_yrs_old	N/A	Vascular Dementia 	15465626
Cerebrospinal_Fluid(CSF)	4.03 (2.51-5.55)	umol/L	Adult:>18_yrs_old	Both	Vascular Dementia	15465626
Cerebrospinal_Fluid(CSF)	6.9 +/- 3.2 	umol/L	Elderly:>65_yrs_old	Both	Alzheimer's Disease	15465626


# Associated_Disorders:
Alzheimer's Disease; Antidiuresis; Down's Syndrome; Kidney Disease; Liver Disease (Cirrhosis); Some Brain Cancers; Spina bifida; Vascular Dementia

# Pathway_Names:
Glycerophospholipid metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00564

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5286

# Metabolic_Enzyme_1_Name:
1-O-acylceramide synthase precursor

# Metabolic_Enzyme_1_Synonyms:
ACS; Lysosomal phospholipase A2; Lysophospholipase 3; LPLA2; LCAT-like lysophospholipase; LLPL

# Metabolic_Enzyme_1_Gene_Name:
LYPLA3

# Metabolic_Enzyme_1_Protein_Sequence:
>1Oacylceramide synthase precursor
MGLHLRPYRVGLLPDGLLFLLLLLMLLADPALPAGRHPPVVLVPGDLGNQLEAKLDKPTV
VHYLCSKKTESYFTIWLNLELLLPVIIDCWIDNIRLVYNKTSRATQFPDGVDVRVPGFGK
TFSLEFLDPSKSSVGSYFHTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALREM
IEEMYQLYGGPVVLVAHSMGNMYTLYFLQRQPQAWKDKYIRAFVSLGAPWGGVAKTLRVL
ASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNYTWSPEKVFVQTPTINYTLRDYRKFFQ
DIGFEDGWLMRQDTEGLVEATMPPGVQLHCLYGTGVPTPDSFYYESFPDRDPKICFGDGD
GTVNLKSALQCQAWQSRQEHQVLLQELPGSEHIEMLANATTLAYLKRVLLGP

# Metabolic_Enzyme_1_Number_of_Residues:
412

# Metabolic_Enzyme_1_Molecular_Weight:
46658

# Metabolic_Enzyme_1_Theoretical_pI:
6.72

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
Function:  O-acyltransferase activity
Function:  phosphatidylcholine-sterol O-acyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N- acetylsphingosine and the concomitant release of a lyso- phospholipid. May have weak lysophospholipase activity

# Metabolic_Enzyme_1_Pathway:
Not Available

# Metabolic_Enzyme_1_Reaction:
Not Available

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF02450:LACT

# Metabolic_Enzyme_1_Signals:
1-33

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.1.1.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
4589720

# Metabolic_Enzyme_1_SwissProt_ID:
LYPA3_HUMAN (Q8NCC3)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
LYPLA3

# Metabolic_Enzyme_1_Geneatlas_id:
LYPLA3

# Metabolic_Enzyme_1_hgnc_id:
HGNC:17163

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Lysosome. Secreted protein

# Metabolic_Enzyme_1_Gene_Sequence:
>1239 bp
ATGGGCCTCCACCTCCGCCCCTACCGTGTGGGGCTGCTCCCGGATGGCCTCCTGTTCCTC
TTGCTGCTGCTAATGCTGCTCGCGGACCCAGCGCTCCCGGCCGGACGTCACCCCCCAGTG
GTGCTGGTCCCTGGTGATTTGGGTAACCAACTGGAAGCCAAGCTGGACAAGCCGACAGTG
GTGCACTACCTCTGCTCCAAGAAGACCGAAAGCTACTTCACAATCTGGCTGAACCTGGAA
CTGCTGCTGCCTGTCATCATTGACTGCTGGATTGACAATATCAGGCTGGTTTACAACAAA
ACATCCAGGGCCACCCAGTTTCCTGATGGTGTGGATGTACGTGTCCCTGGCTTTGGGAAG
ACCTTCTCACTGGAGTTCCTGGACCCCAGCAAAAGCAGCGTGGGTTCCTATTTCCACACC
ATGGTGGAGAGCCTTGTGGGCTGGGGCTACACACGGGGTGAGGATGTCCGAGGGGCTCCC
TATGACTGGCGCCGAGCCCCAAATGAAAACGGGCCCTACTTCCTGGCCCTCCGCGAGATG
ATCGAGGAGATGTACCAGCTGTATGGGGGCCCCGTGGTGCTGGTTGCCCACAGTATGGGC
AACATGTACACGCTCTACTTTCTGCAGCGGCAGCCGCAGGCCTGGAAGGACAAGTATATC
CGGGCCTTCGTGTCACTGGGTGCGCCCTGGGGGGGCGTGGCCAAGACCCTGCGCGTCCTG
GCTTCAGGAGACAACAACCGGATCCCAGTCATCGGGCCCCTGAAGATCCGGGAGCAGCAG
CGGTCAGCTGTCTCCACCAGCTGGCTGCTGCCCTACAACTACACATGGTCACCTGAGAAG
GTGTTCGTGCAGACACCCACAATCAACTACACACTGCGGGACTACCGCAAGTTCTTCCAG
GACATCGGCTTTGAAGATGGCTGGCTCATGCGGCAGGACACAGAAGGGCTGGTGGAAGCC
ACGATGCCACCTGGCGTGCAGCTGCACTGCCTCTATGGCACTGGCGTCCCCACACCAGAC
TCCTTCTACTATGAGAGCTTCCCTGACCGTGACCCTAAAATCTGCTTTGGTGACGGCGAT
GGTACTGTGAACTTGAAGAGTGCCCTGCAGTGCCAGGCCTGGCAGAGCCGCCAGGAGCAC
CAAGTGTTGCTGCAGGAGCTGCCAGGCAGCGAGCACATCGAGATGCTGGCCAACGCCACC
ACCCTGGCCTATCTGAAACGTGTGCTCCTTGGGCCCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AB017494

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_1_Locus:
16q22.1

# Metabolic_Enzyme_1_SNPs:
rs3743739; rs7672; rs9935022; rs1975802; rs2290700; rs16957784; rs12446418; rs1971546; rs3826164; rs10500543; rs12444188; rs8062085; rs12600062; rs2290699; rs17688065; rs11075670; rs8063214; rs10852439; rs17688076; rs7189794; rs28565410; rs34573759; rs34767979; rs11550043; rs9922331; rs35744179; rs3180464; rs34645528; rs11368218; rs34967472; rs12918044; rs3068687; rs36037115; rs5817633; rs12918043; rs28536091; rs35588224; rs35048006; rs3214854; rs12444774; rs12918145; rs36121098; rs3785110; rs8053594; rs9923137; rs10695552; rs168770; rs12324926; rs12918064; rs34546790; rs7184506; rs7189381; rs12325587; rs7189155; rs12324938; rs35155877; rs12102971; rs12447119; rs12596500; rs12924125; rs2863981; rs7184821; rs7187202; rs8056893; rs9930792; rs9933029

# Metabolic_Enzyme_1_General_References:
10092508; 12975309; 11790796

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5295

# Metabolic_Enzyme_2_Name:
Acyl-protein thioesterase 2

# Metabolic_Enzyme_2_Synonyms:
Lysophospholipase II; LPL- I

# Metabolic_Enzyme_2_Gene_Name:
LYPLA2

# Metabolic_Enzyme_2_Protein_Sequence:
>Acylprotein thioesterase 2
MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAP
RIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGG
FSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPMVP
VRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV

# Metabolic_Enzyme_2_Number_of_Residues:
231

# Metabolic_Enzyme_2_Molecular_Weight:
24737

# Metabolic_Enzyme_2_Theoretical_pI:
7.25

# Metabolic_Enzyme_2_GO_Classification:
Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity

# Metabolic_Enzyme_2_Pathway:
Not Available

# Metabolic_Enzyme_2_Reaction:
Not Available

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF02230:Abhydrolase_2

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.1.1.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
3859560

# Metabolic_Enzyme_2_SwissProt_ID:
LYPA2_HUMAN (O95372)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
LYPLA2

# Metabolic_Enzyme_2_Geneatlas_id:
LYPLA2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:6738

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm (Probable)

# Metabolic_Enzyme_2_Gene_Sequence:
>696 bp
ATGTGTGGTAACACCATGTCTGTGCCCCTGCTCACCGATGCTGCCACCGTGTCTGGAGCT
GAGCGGGAAACGGCCGCGGTTATTTTTTTACATGGACTTGGAGACACAGGGCACAGCTGG
GCTGACGCCCTCTCCACCATCCGGCTCCCTCACGTCAAGTACATCTGTCCCCATGCGCCT
AGGATCCCTGTGACCCTCAACATGAAGATGGTGATGCCCTCCTGGTTTGACCTGATGGGG
CTGAGTCCAGATGCCCCAGAGGACGAGGCTGGCATCAAGAAGGCAGCAGAGAACATCAAG
GCCTTGATTGAGCATGAAATGAAGAACGGGATCCCTGCCAATCGAATCGTCCTGGGAGGC
TTTTCACAGGGCGGGGCCCTGTCCCTCTACACGGCCCTCACCTGCCCCCACCCTCTGGCT
GGCATCGTGGCGTTGAGCTGCTGGCTGCCTCTGCACCGGGCCTTCCCCCAGGCAGCTAAT
GGCAGTGCCAAGGACCTGGCCATACTCCAGTGCCATGGGGAGCTGGACCCCATGGTGCCC
GTACGGTTTGGGGCCCTGACGGCTGAGAAGCTCCGGTCTGTTGTCACACCTGCCAGGGTC
CAGTTCAAGACATACCCGGGTGTCATGCACAGCTCCTGTCCTCAGGAGATGGCAGCTGTG
AAGGAATTTCTTGAGAAGCTGCTGCCTCCTGTCTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF098668

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_2_Locus:
1p36.12-p35.1

# Metabolic_Enzyme_2_SNPs:
rs2502985; rs2232982; rs2232979; rs11584220; rs2232978; rs2232985; rs2232986; rs2232984; rs3835423; rs2232976; rs2232977; rs2232981; rs2232980; rs2232983; rs2232975; rs35791072; rs1042436; rs1046924; rs1049988; rs11714; rs12031592; rs12131539; rs15778; rs1803612; rs1803613; rs2076343; rs2473381; rs2473382; rs28940882; rs28940883; rs28940885; rs3177810; rs3177811; rs3177814; rs3179862; rs3180382; rs3180383; rs3180545; rs3180546; rs3180547; rs3180549; rs3203593; rs3209973; rs6692104; rs760941

# Metabolic_Enzyme_2_General_References:
Not Available

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5289

# Metabolic_Enzyme_3_Name:
Cytosolic phospholipase A2

# Metabolic_Enzyme_3_Synonyms:
cPLA2; Phospholipase A2 group IVA[Includes: Phospholipase A2; Phosphatidylcholine 2- acylhydrolase; Lysophospholipase

# Metabolic_Enzyme_3_Gene_Name:
PLA2G4A

# Metabolic_Enzyme_3_Protein_Sequence:
>Cytosolic phospholipase A2
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRT
RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEV
PFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEG
LHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSH
PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIG
ETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYG
TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEE
LENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFN
TREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDV
KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN
KLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYKAPGVPRETE
EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRR
QNPSRCSVSLSNVEARRFFNKEFLSKPKA

# Metabolic_Enzyme_3_Number_of_Residues:
749

# Metabolic_Enzyme_3_Molecular_Weight:
85212

# Metabolic_Enzyme_3_Theoretical_pI:
5.03

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  lipase activity
Function:  phospholipase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  phospholipid metabolism
Process:  phospholipid catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response

# Metabolic_Enzyme_3_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_3_Reaction:
2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00168:C2;
PF01735:PLA2_B

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.1.1.4;EC 3.1.1.5

# Metabolic_Enzyme_3_GenBank_ID_Protein:
190007

# Metabolic_Enzyme_3_SwissProt_ID:
PA24A_HUMAN (P47712)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
PLA2G4A

# Metabolic_Enzyme_3_Geneatlas_id:
PLA2G4A

# Metabolic_Enzyme_3_hgnc_id:
HGNC:9035

# Metabolic_Enzyme_3_PDB_ID:
1CJY

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion

# Metabolic_Enzyme_3_Gene_Sequence:
>2250 bp
ATGTCATTTATAGATCCTTACCAGCACATTATAGTGGAGCACCAGTATTCCCACAAGTTT
ACGGTAGTGGTGTTACGTGCCACCAAAGTGACAAAGGGGGCCTTTGGTGACATGCTTGAT
ACTCCAGATCCCTATGTGGAACTTTTTATCTCTACAACCCCTGACAGCAGGAAGAGAACA
AGACATTTCAATAATGACATAAACCCTGTGTGGAATGAGACCTTTGAATTTATTTTGGAT
CCTAATCAGGAAAATGTTTTGGAGATTACGTTAATGGATGCCAATTATGTCATGGATGAA
ACTCTAGGGACAGCAACATTTACTGTATCTTCTATGAAGGTGGGAGAAAAGAAAGAAGTT
CCTTTTATTTTCAACCAAGTCACTGAAATGGTTCTAGAAATGTCTCTTGAAGTTTGCTCA
TGCCCAGACCTACGATTTAGTATGGCTCTGTGTGATCAGGAGAAGACTTTCAGACAACAG
AGAAAAGAACACATAAGGGAGAGCATGAAGAAACTCTTGGGTCCAAAGAATAGTGAAGGA
TTGCATTCTGCACGTGATGTGCCTGTGGTAGCCATATTGGGTTCAGGTGGGGGTTTCCGA
GCCATGGTGGGATTCTCTGGTGTGATGAAGGCATTATACGAATCAGGAATTCTGGATTGT
GCTACCTACGTTGCTGGTCTTTCTGGCTCCACCTGGTATATGTCAACCTTGTATTCTCAC
CCTGATTTTCCAGAGAAAGGGCCAGAGGAGATTAATGAAGAACTAATGAAAAATGTTAGC
CACAATCCCCTTTTACTTCTCACACCACAGAAAGTTAAAAGATATGTTGAGTCTTTATGG
AAGAAGAAAAGCTCTGGACAACCTGTCACCTTTACTGATATCTTTGGGATGTTAATAGGA
GAAACACTAATTCATAATAGAATGAATACTACTCTGAGCAGTTTGAAGGAAAAAGTTAAT
ACTGCACAATGCCCTTTACCTCTTTTCACCTGTCTTCATGTCAAACCTGACGTTTCAGAG
CTGATGTTTGCAGATTGGGTTGAATTTAGTCCATACGAAATTGGCATGGCTAAATATGGT
ACTTTTATGGCTCCCGACTTATTTGGAAGCAAATTTTTTATGGGAACAGTCGTTAAGAAG
TATGAAGAAAACCCCTTGCATTTCTTAATGGGTGTCTGGGGCAGTGCCTTTTCCATATTG
TTCAACAGAGTTTTGGGCGTTTCTGGTTCACAAAGCAGAGGCTCCACAATGGAGGAAGAA
TTAGAAAATATTACCACAAAGCATATTGTGAGTAATGATAGCTCGGACAGTGATGATGAA
TCACACGAACCCAAAGGCACTGAAAATGAAGATGCTGGAAGTGACTATCAAAGTGATAAT
CAAGCAAGTTGGATTCATCGTATGATAATGGCCTTGGTGAGTGATTCAGCTTTATTCAAT
ACCAGAGAAGGACGTGCTGGGAAGGTACACAACTTCATGCTGGGCTTGAATCTCAATACA
TCTTATCCACTGTCTCCTTTGAGTGACTTTGCCACACAGGACTCCTTTGATGATGATGAA
CTGGATGCAGCTGTAGCAGATCCTGATGAATTTGAGCGAATATATGAGCCTCTGGATGTC
AAAAGTAAAAAGATTCATGTAGTGGACAGTGGGCTCACATTTAACCTGCCGTATCCCTTG
ATACTGAGACCTCAGAGAGGGGTTGATCTCATAATCTCCTTTGACTTTTCTGCAAGGCCA
AGTGACTCTAGTCCTCCGTTCAAGGAACTTCTACTTGCAGAAAAGTGGGCTAAAATGAAC
AAGCTCCCCTTTCCAAAGATTGATCCTTATGTGTTTGATCGGGAAGGGCTGAAGGAGTGC
TATGTCTTTAAACCCAAGAATCCTGATATGGAGAAAGATTGCCCAACCATCATCCACTTT
GTTCTGGCCAACATCAACTTCAGAAAGTACAAGGCTCCAGGTGTTCCAAGGGAAACTGAG
GAAGAGAAAGAAATCGCTGACTTTGATATTTTTGATGACCCAGAATCACCATTTTCAACC
TTCAATTTTCAATATCCAAATCAAGCATTCAAAAGACTACATGATCTTATGCACTTCAAT
ACTCTGAACAACATTGATGTGATAAAAGAAGCCATGGTTGAAAGCATTGAATATAGAAGA
CAGAATCCATCTCGTTGCTCTGTTTCCCTTAGTAATGTTGAGGCAAGAAGATTTTTCAAC
AAGGAGTTTCTAAGTAAACCCAAAGCATAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M72393

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_3_Locus:
1q25

# Metabolic_Enzyme_3_SNPs:
rs2307198; rs12720691; rs10752976; rs4651331; rs2076075; rs7535459; rs12720707; rs11591148; rs12720485; rs3820185; rs10798059; rs12022299; rs12720496; rs1473676; rs12070719; rs6682761; rs6669230; rs6425051; rs10911930; rs11578084; rs6425050; rs11455181; rs10489406; rs4651330; rs12720495; rs2205897; rs9645303; rs16825998; rs12720708; rs7518131; rs12720488; rs12065442; rs12720490; rs12097836; rs10911927; rs7522183; rs12720486; rs2179189; rs2223307; rs2891262; rs1980444; rs2223309; rs2383555; rs726706; rs1018378; rs6672324; rs1474590; rs4336803; rs10798065; rs1569480; rs7555326; rs10737277; rs1160719; rs4650708; rs10752988; rs7545121; rs12062681; rs10911946; rs12068233; rs6678708; rs6690185; rs10911943; rs10798070; rs1569479; rs6682481; rs7542180; rs7519192; rs969357; rs932476; rs10752989; rs10911948; rs10911971; rs10798067; rs12072973; rs6697116; rs2307199; rs10737272; rs1033410; rs6678709; rs6698103; rs4651343; rs10752985; rs7554339; rs5027750; rs2383556; rs10798062; rs6683363; rs10911945; rs7542659; rs2207209; rs6695515; rs10911949; rs1003348; rs1977064; rs969358; rs2223308; rs10752983; rs2064115; rs6697145; rs763419; rs6683515; rs2891263; rs7540602; rs10157410; rs10911947; rs2307200; rs10798069; rs10911944; rs2383553; rs2891264; rs2049963; rs10911953; rs2383554; rs11587539; rs10911956; rs6661772; rs1980445; rs10489410; rs10911937; rs1555205; rs12129917; rs10798076; rs10489409; rs17591814; rs6425064; rs4650706; rs10911973; rs2024656; rs6682706; rs10911955; rs2076675; rs4272579; rs12720576; rs10798064; rs12404877; rs10911968; rs10911972; rs12720500; rs6425065; rs2273169; rs10911935; rs16826051; rs12567822; rs4650711; rs12720573; rs6425059; rs12720528; rs12720566; rs6666834; rs10489408; rs12564966; rs4651337; rs6686860; rs10911969; rs12720639; rs10798063; rs4651339; rs7547993; rs2383551; rs10911934; rs3736741; rs12720613; rs12720520; rs2307193; rs12406315; rs12720687; rs12563152; rs12066585; rs12091045; rs6688584; rs7526089; rs10798075; rs12720571; rs12720699; rs10911966; rs7555140; rs4651336; rs6704304; rs12720662; rs6664561; rs6685652; rs12749354; rs10798060; rs10911933; rs6693896; rs2307195; rs4433346; rs12726519; rs10489407; rs4402086; rs12720686; rs10798068; rs12720704; rs12720702; rs10911967; rs10737270; rs6425058; rs2891258; rs12720642; rs12353944; rs10737278; rs12720597; rs12131989; rs10911952; rs12042344; rs6686848; rs12720541; rs7526761; rs12720554; rs12720526; rs12353945; rs12409191; rs10911942; rs6425053; rs2307196; rs10737276; rs12746200; rs12401750; rs12139172; rs12720667; rs2064471; rs10752981; rs6699187; rs11576330; rs2223310; rs12720536; rs6665700; rs10752979; rs7521601; rs12567046; rs6678716; rs6696406; rs16826049; rs12144159; rs12720497; rs6662822; rs6425054; rs10737275; rs10911938; rs6683416; rs6425066; rs2307197; rs1555202; rs6690542; rs12720502; rs12720519; rs10688954; rs12720535; rs7416329; rs2142761; rs10752982; rs12407699; rs1555204; rs12128551; rs6683619; rs6662687; rs10752978; rs12131535; rs10737274; rs6678825; rs10752977; rs12073758; rs7522213; rs1160718; rs6425067; rs12568962; rs10911963; rs10157338; rs11802826; rs4651334; rs16826045; rs6656909; rs12073712; rs6685207; rs7547156; rs12720586; rs7541946; rs12720696; rs6691054; rs6672835; rs6695425; rs12720584; rs12720603; rs16670; rs6675898; rs12720572; rs35782442; rs4650712; rs12567071; rs2891261; rs12720625; rs16826065; rs12720565; rs6680308; rs16826055; rs6699070; rs12720537; rs12720508; rs12720605; rs10798073; rs12720700; rs12136279; rs7532616; rs6685195; rs12720658; rs16826181; rs12405420; rs12720650; rs12720654; rs12720622; rs10911951; rs6688358; rs12720556; rs12720680; rs12720560; rs12720514; rs2223909; rs12720552; rs12720527; rs12720637; rs12720549; rs6703952; rs10737273; rs10157406; rs975762; rs12720672; rs6683622; rs12720570; rs12720664; rs6425062; rs10798066; rs4276871; rs11805429; rs12720644; rs10911960; rs12720516; rs12720505; rs12720548; rs12720675; rs11806629; rs6675166; rs12720630; rs10911950; rs12720539; rs10732978; rs12720550; rs12720530; rs12720559; rs12691467; rs11577826; rs12720660; rs6700651; rs6675578; rs12720531; rs6685468; rs2207212; rs6690278; rs9803785; rs4650705; rs12720673; rs17601344; rs12720615; rs12567135; rs7547623; rs10737271; rs5007825; rs4651333; rs10798072; rs12720610; rs12720534; rs17591849; rs10798077; rs16826212; rs2223306; rs6683421; rs12720692; rs12720564; rs12720595; rs17526478; rs6668908; rs12720504; rs16826197; rs12720563; rs6425052; rs12090109; rs16826185; rs12720655; rs7534926; rs6688401; rs4650715; rs12720555; rs12720580; rs10911959; rs10752980; rs12720677; rs12720517; rs10158652; rs12567058; rs1555201; rs9804084; rs10798061; rs12720547; rs2383552; rs12720705; rs10911964; rs6688292; rs16826066; rs1033409; rs12720551; rs725892; rs5007826; rs12720628; rs12720638; rs12720582; rs12720633; rs2205898; rs11802050; rs10911931; rs12720511; rs4650709; rs10911958; rs12720684; rs10798074; rs1980446; rs12720557; rs12720617; rs12125857; rs12720676; rs7512281; rs12720561; rs16826060; rs11799495; rs12720594; rs2891259; rs7542836; rs6680303; rs7555537; rs12720690; rs10911965; rs12720544; rs16826042; rs2223305; rs12720581; rs7514702; rs12720634; rs5007824; rs6425055; rs6687896; rs4651332; rs12720689; rs12720694; rs12720669; rs12720656; rs2207213; rs979924; rs12720709; rs12720715; rs6684111; rs12720714; rs12720711; rs12720484; rs2066730; rs12720588; rs34758865; rs12720706; rs34500623; rs34278354; rs12720493; rs36079774; rs35180943; rs34635375; rs35145197; rs34795932; rs35339490; rs12093847; rs12744150; rs3795405; rs11543184; rs12095150; rs12720491; rs34716672; rs34429516; rs7521834; rs6662798; rs12720492; rs2307194; rs35977655; rs7525336; rs12734741; rs36062883; rs35641837; rs12084339; rs28595275; rs35960872; rs10911929; rs34827324; rs11810276; rs12070830; rs12720494; rs10651334; rs12720487; rs10911928; rs34397242; rs11577918; rs12734740; rs35762270; rs28679753; rs34496849; rs34438674; rs10566895; rs5779305; rs12033196; rs34724808; rs34832532; rs34045840; rs34986389; rs7513536; rs34537878; rs35209416; rs12720614; rs12720665; rs10712560; rs12720562; rs35723333; rs10609057; rs11371525; rs4650710; rs11406614; rs10695580; rs34215604; rs11371082; rs12720620; rs12720545; rs12742851; rs6702522; rs12720670; rs6671076; rs12720538; rs12720631; rs12720515; rs10911941; rs34711478; rs4651338; rs12720513; rs7522714; rs34670614; rs10911936; rs12720585; rs34385931; rs5779307; rs10752987; rs2207210; rs12720646; rs12720577; rs34340996; rs12753440; rs5779313; rs35091910; rs28633464; rs12751616; rs6679956; rs4007494; rs11399679; rs34101258; rs12128554; rs34680053; rs34586699; rs28412072; rs12720546; rs7527362; rs35773380; rs12720621; rs12022898; rs11390247; rs10700665; rs10592003; rs12720671; rs28691172; rs16826187; rs12745030; rs12720608; rs10911962; rs12720589; rs12720583; rs12720632; rs35131542; rs6682327; rs35260952; rs12720697; rs7544607; rs34405767; rs28676882; rs41264626; rs34416417; rs35443164; rs12566020; rs35801522; rs12032535; rs35069250; rs6691582; rs12095733; rs10752984; rs35183959; rs34391401; rs2205899; rs2205900; rs12129429; rs35047746; rs35174355; rs12131723; rs10911961; rs34709541; rs33956999; rs34677530; rs35412398; rs12088010; rs12720503; rs12720553; rs35618673; rs12141266; rs6696994; rs12720579; rs12720606; rs34191261; rs35003727; rs12720590; rs2207211; rs34356253; rs12071785; rs6675261; rs7546816; rs10627684; rs12720698; rs33958012; rs7524685; rs12122892; rs34414453; rs17592348; rs6683074; rs34543034; rs35037006; rs36037957; rs12063845; rs34089378; rs35264080; rs28606018; rs7413826; rs10538195; rs12720567; rs12074730; rs34098374; rs2383557; rs2891260; rs10911940; rs36020072; rs5779309; rs7545760; rs12720701; rs12720661; rs4540601; rs10708783; rs12720529; rs12720506; rs12057343; rs12720627; rs12720693; rs12720509; rs10631853; rs12720663; rs35389587; rs10708367; rs34107747; rs35813341; rs12720681; rs6662570; rs5779311; rs12742431; rs12738756; rs12758086; rs5779312; rs35947118; rs10702515; rs12720578; rs6703998; rs12720521; rs35425521; rs35800521; rs12720643; rs12720518; rs12720674; rs41264620; rs12720592; rs28493593; rs35050511; rs41516146; rs33948033; rs11375182; rs28863289; rs2017443; rs12720635; rs35712617; rs12720558; rs12720682; rs10674434; rs10609058; rs12720679; rs34796725; rs11388924; rs12720499; rs12720525; rs12720666; rs28896572; rs10599543; rs34632328; rs34437304; rs6425063; rs12720540; rs34350773; rs1467392; rs4650714; rs7536112; rs34147625; rs12720626; rs12720522; rs10596911; rs12720629; rs6685936; rs34920672; rs12730988; rs12121329; rs7526859; rs11428922; rs16826040; rs34398848; rs12720657; rs12720533; rs5014276; rs12720636; rs5779310; rs12720510; rs12744618; rs6425060; rs10634937; rs12720695; rs12720618; rs12720685; rs34820266; rs12125608; rs35455351; rs12720678; rs12720587; rs10911939; rs34441009; rs12744872; rs34503201; rs12720523; rs7520075; rs12720542; rs11426942; rs12088931; rs12143244; rs10633079; rs12720703; rs11460224; rs35869038; rs6678801; rs12128380; rs6675277; rs2143998; rs34952820; rs33991046; rs10578509; rs12720507; rs12720641; rs6425061; rs6674263; rs41264622; rs11268618; rs12720575; rs12730485; rs34117619; rs12720524; rs3060324; rs12720640; rs11307887; rs12720543; rs35673805; rs12720569; rs12129578; rs12720601; rs12720683; rs12143166; rs12747953; rs12720668; rs5007827; rs12409076; rs6670830; rs1555203; rs6695438; rs11441392; rs10647657; rs34948178; rs35146633; rs11314983; rs34814979; rs12097804; rs10689140; rs12720574; rs12720688; rs12077935; rs11387651; rs34068761; rs5007828; rs34866477; rs12730349; rs12720653; rs10707298; rs28878026; rs28634506; rs10709187; rs35257640; rs35387925; rs34796478; rs34017667; rs10752986; rs4262498; rs11410376; rs34113977; rs28749294; rs34023737; rs5779306; rs12720498; rs35843046; rs10585011; rs12720512; rs35114616; rs34490217; rs12744998; rs7416510; rs12720616; rs35566402; rs35454348; rs11320837; rs10657628; rs35523045; rs11805955; rs35126168; rs41519945; rs41264624; rs36064066; rs10647022; rs4650713; rs12720501; rs12071782; rs35214657; rs10603183; rs34029312; rs6678891; rs12720593; rs7551458; rs10681360; rs12123893; rs7523149; rs41453146; rs12720483; rs10158368; rs7556320; rs11802141; rs12066562; rs12720710; rs12066511; rs5779304; rs12092415; rs12720712; rs12720713; rs12066519; rs12066344; rs10752990; rs10798078; rs10911976; rs10911978; rs11590854; rs12037836; rs12746284; rs1474797; rs2143999; rs2144000; rs4651345; rs6661727; rs6696144; rs7414079; rs7544719; rs761517

# Metabolic_Enzyme_3_General_References:
1904318; 1869522; 8381049; 11416127; 9430701; 9665851

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5300

# Metabolic_Enzyme_4_Name:
Cardiotrophin-like cytokine factor 1 precursor

# Metabolic_Enzyme_4_Synonyms:
B cell-stimulating factor 3; BSF-3; Novel neurotrophin-1; NNT-1

# Metabolic_Enzyme_4_Gene_Name:
CLCF1

# Metabolic_Enzyme_4_Protein_Sequence:
>Cardiotrophinlike cytokine factor 1 precursor
MDLRAGDSWGMLACLCTVLWHLPAVPALNRTGDPGPGPSIQKTYDLTRYLEHQLRSLAGT
YLNYLGPPFNEPDFNPPRLGAETLPRATVDLEVWRSLNDKLRLTQNYEAYSHLLCYLRGL
NRQAATAELRRSLAHFCTSLQGLLGSIAGVMAALGYPLPQPLPGTEPTWTPGPAHSDFLQ
KMDDFWLLKELQTWLWRSAKDFNRLKKKMQPPAAAVTLHLGAHGF

# Metabolic_Enzyme_4_Number_of_Residues:
225

# Metabolic_Enzyme_4_Molecular_Weight:
25176

# Metabolic_Enzyme_4_Theoretical_pI:
8.61

# Metabolic_Enzyme_4_GO_Classification:
Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor

# Metabolic_Enzyme_4_Pathway:
Not Available

# Metabolic_Enzyme_4_Reaction:
Not Available

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF06875:PRF

# Metabolic_Enzyme_4_Signals:
1-27

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.1.1.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
6007641

# Metabolic_Enzyme_4_SwissProt_ID:
CLCF1_HUMAN (Q9UBD9)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CLCF1

# Metabolic_Enzyme_4_Geneatlas_id:
CLCF1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:17412

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_4_Gene_Sequence:
>678 bp
ATGGACCTCCGAGCAGGGGACTCGTGGGGGATGTTAGCGTGCCTGTGCACGGTGCTCTGG
CACCTCCCTGCAGTGCCAGCTCTCAATCGCACAGGGGACCCAGGGCCTGGCCCCTCCATC
CAGAAAACCTATGACCTCACCCGCTACCTGGAGCACCAACTCCGCAGCTTGGCTGGGACC
TATCTGAACTACCTGGGCCCCCCTTTCAACGAGCCAGACTTCAACCCTCCCCGCCTGGGG
GCAGAGACTCTGCCCAGGGCCACTGTTGACTTGGAGGTGTGGCGAAGCCTCAATGACAAA
CTGCGGCTGACCCAGAACTACGAGGCCTACAGCCACCTTCTGTGTTACTTGCGTGGCCTC
AACCGTCAGGCTGCCACTGCTGAGCTGCGCCGCAGCCTGGCCCACTTCTGCACCAGCCTC
CAGGGCCTGCTGGGCAGCATTGCGGGCGTCATGGCAGCTCTGGGCTACCCACTGCCCCAG
CCGCTGCCTGGGACTGAACCCACTTGGACTCCTGGCCCTGCCCACAGTGACTTCCTCCAG
AAGATGGACGACTTCTGGCTGCTGAAGGAGCTGCAGACCTGGCTGTGGCGCTCGGCCAAG
GACTTCAACCGGCTCAAGAAGAAGATGCAGCCTCCAGCAGCTGCAGTCACCCTGCACCTG
GGGGCTCATGGCTTCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF176911

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_4_Locus:
11q13.3

# Metabolic_Enzyme_4_SNPs:
rs867193; rs4930197; rs1790738; rs3781941; rs3781942; rs11826923; rs11227780; rs1638569; rs1790737; rs12788752; rs1790739; rs1790740; rs3758943; rs34057094; rs35896036; rs35385218; rs35544864; rs4024257; rs3837414; rs35112616; rs885763; rs35983106; rs5792415; rs10578684; rs34865354; rs10666079; rs12790741; rs5792414; rs885764; rs34198998; rs3837416; rs35361219; rs34641131; rs10666811; rs35573072; rs3837415; rs34550280; rs7484118; rs35764861; rs4320957; rs11227779; rs11227778; rs12222500; rs12288324; rs1419861; rs1638566; rs1638567; rs1638570; rs1638571; rs1638572; rs1790731; rs1790735; rs34087937; rs34468513; rs35176549; rs3909168; rs4930198; rs869154

# Metabolic_Enzyme_4_General_References:
10500198; 10448081

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5285

# Metabolic_Enzyme_5_Name:
Acyl-protein thioesterase 1

# Metabolic_Enzyme_5_Synonyms:
Lysophospholipase 1; Lysophospholipase I

# Metabolic_Enzyme_5_Gene_Name:
LYPLA1

# Metabolic_Enzyme_5_Protein_Sequence:
>Acylprotein thioesterase 1
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRP
VTLNMNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQ
GGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLM
FGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID

# Metabolic_Enzyme_5_Number_of_Residues:
230

# Metabolic_Enzyme_5_Molecular_Weight:
24670

# Metabolic_Enzyme_5_Theoretical_pI:
6.77

# Metabolic_Enzyme_5_GO_Classification:
Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Also has low lysophospholipase activity

# Metabolic_Enzyme_5_Pathway:
Not Available

# Metabolic_Enzyme_5_Reaction:
Not Available

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF02230:Abhydrolase_2

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.1.1.5

# Metabolic_Enzyme_5_GenBank_ID_Protein:
3415123

# Metabolic_Enzyme_5_SwissProt_ID:
LYPA1_HUMAN (O75608)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
LYPLA1

# Metabolic_Enzyme_5_Geneatlas_id:
LYPLA1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:6737

# Metabolic_Enzyme_5_PDB_ID:
1FJ2

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>693 bp
ATGTGCGGCAATAACATGTCAACCCCGCTGCCCGCCATCGTGCCCGCCGCCCGGAAGGCC
ACCGCTGCGGTGATTTTCCTGCATGGATTGGGAGATACTGGGCACGGATGGGCAGAAGCC
TTTGCAGGTATCAGAAGTTCACATATCAAATATATCTGCCCGCATGCGCCTGTTAGGCCT
GTTACATTAAATATGAACGTGGCTATGCCTTCATGGTTTGATATTATTGGGCTTTCACCA
GATTCACAGGAGGATGAATCTGGGATTAAACAGGCAGCAGAAAATATAAAAGCTTTGATT
GATCAAGAAGTGAAGAATGGCATTCCTTCTAACAGAATTATTTTGGGAGGGTTTTCTCAG
GGAGGAGCTTTATCTTTATATACTGCCCTTACCACACAGCAGAAACTGGCAGGTGTCACT
GCACTCAGTTGCTGGCTTCCACTTCGGGCTTCCTTTCCACAGGGTCCTATCGGTGGTGCT
AATAGAGATATTTCTATTCTCCAGTGCCACGGGGATTGTGACCCTTTGGTTCCCCTGATG
TTTGGTTCTCTTACGGTGGAAAAACTAAAAACATTGGTGAATCCAGCCAATGTGACCTTT
AAAACCTATGAAGGTATGATGCACAGTTCGTGTCAACAGGAAATGATGGATGTCAAGCAA
TTCATTGATAAACTCCTACCTCCAATTGATTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AF081281

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_5_Locus:
8q11.23

# Metabolic_Enzyme_5_SNPs:
rs16919923; rs6473905; rs8822; rs4737486; rs4506187; rs7829394; rs6473908; rs6983694; rs11998000; rs7003793; rs7844299; rs11994629; rs4737485; rs6473907; rs7008593; rs11986605; rs7463083; rs16919753; rs7007031; rs10504160; rs10112111; rs11988830; rs2037068; rs10101097; rs11988859; rs11775545; rs16919924; rs4737479; rs7011379; rs16919750; rs11993367; rs7839276; rs11549451; rs4310181; rs4486181; rs1044691; rs35038027; rs1044604; rs11549452; rs11549447; rs11549455; rs4475455; rs11549454; rs36051350; rs35130790; rs7005653; rs7836760; rs13269916; rs34705172; rs34207117; rs34578596; rs34866895; rs35292579; rs34317314; rs13279277; rs7820688; rs13275711; rs13269847; rs28369337; rs34967619; rs36030049; rs34232589; rs4737480; rs13279284; rs10090273; rs11780155; rs13265668; rs34599244; rs12019384; rs13259254; rs13259230; rs7815998; rs10101967; rs4427146; rs13269571; rs7833336; rs3054305; rs28452332; rs35231924; rs28749838; rs13276007; rs34951751; rs35405582; rs35023326; rs4480103; rs35882577; rs28813536; rs7001391; rs34805415; rs7001356; rs35772548; rs11994366; rs34478960; rs7004430; rs28437156; rs7822750; rs35162856; rs13250609; rs35188512; rs28397021; rs13277892; rs35318714; rs11992220; rs28533970; rs9643481; rs12056824; rs34135278; rs13263441; rs12676310; rs35672696; rs5891512; rs11288082; rs10958395; rs5891513; rs13262695; rs7357559; rs1828835; rs6981386; rs3054289; rs34828721; rs13269238; rs35106127; rs35890246

# Metabolic_Enzyme_5_General_References:
11080636; 11042152

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5293

# Metabolic_Enzyme_6_Name:
Galactoside-binding soluble lectin 13

# Metabolic_Enzyme_6_Synonyms:
Placental tissue protein 13; Placenta protein 13; PP13; Galectin-13

# Metabolic_Enzyme_6_Gene_Name:
LGALS13

# Metabolic_Enzyme_6_Protein_Sequence:
>Galactosidebinding soluble lectin 13
MSSLPVPYKLPVSLSVGSCVIIKGTPIHSFINDPQLQVDFYTDMDEDSDIAFRFRVHFGN
HVVMNRREFGIWMLEETTDYVPFEDGKQFELCIYVHYNEYEIKVNGIRIYGFVHRIPPSF
VKMVQVSRDISLTSVCVCN

# Metabolic_Enzyme_6_Number_of_Residues:
139

# Metabolic_Enzyme_6_Molecular_Weight:
16119

# Metabolic_Enzyme_6_Theoretical_pI:
5.53

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Has lysophospholipase activity

# Metabolic_Enzyme_6_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_6_Reaction:
2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00337:Gal-bind_lectin

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.1.1.5

# Metabolic_Enzyme_6_GenBank_ID_Protein:
6650760

# Metabolic_Enzyme_6_SwissProt_ID:
PP13_HUMAN (Q9UHV8)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
LGALS13

# Metabolic_Enzyme_6_Geneatlas_id:
LGALS13

# Metabolic_Enzyme_6_hgnc_id:
HGNC:15449

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>420 bp
ATGTCTTCTTTACCCGTGCCATACAAACTGCCTGTGTCTTTGTCTGTTGGTTCCTGCGTG
ATAATCAAAGGGACACCAATCCACTCTTTTATCAATGACCCACAGCTGCAGGTGGATTTC
TACACTGACATGGATGAGGATTCAGATATTGCCTTCCGTTTCCGAGTGCACTTTGGCAAT
CATGTGGTCATGAACAGGCGTGAGTTTGGGATATGGATGTTGGAGGAGACAACAGACTAC
GTGCCCTTTGAGGATGGCAAACAATTTGAGCTGTGCATCTACGTACATTACAATGAGTAT
GAGATAAAGGTCAATGGCATACGCATTTACGGCTTTGTCCATCGAATCCCGCCATCATTT
GTGAAGATGGTGCAAGTGTCGAGAGATATCTCCCTGACCTCAGTGTGTGTCTGCAATTGA


# Metabolic_Enzyme_6_GenBank_ID_Gene:
AF117383

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_6_Locus:
19q13.1

# Metabolic_Enzyme_6_SNPs:
rs2158964; rs2233706; rs2233709; rs17795657; rs1986156; rs1014206; rs3764844; rs2233708; rs12610294; rs3764843; rs10409099; rs11881603; rs2233711; rs1801654; rs2233710; rs2233707; rs9917050; rs28445525; rs12978134; rs10426654; rs2233703; rs35552633; rs3764842; rs2233704; rs2233705; rs2233702; rs10408486; rs10412234; rs10412744; rs10414890; rs10424213; rs10426515; rs10500280; rs11881743; rs12980535; rs12981089; rs12985936; rs2215004; rs4802044; rs6508877; rs6508878; rs682287; rs7245819; rs7251429; rs7259935; rs8106020

# Metabolic_Enzyme_6_General_References:
10527825; 6856484

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5299

# Metabolic_Enzyme_7_Name:
Eosinophil lysophospholipase

# Metabolic_Enzyme_7_Synonyms:
Charcot-Leyden crystal protein; Lysolecithin acylhydrolase; CLC; Galectin-10

# Metabolic_Enzyme_7_Gene_Name:
CLC

# Metabolic_Enzyme_7_Protein_Sequence:
>Eosinophil lysophospholipase
MSLLPVPYTEAASLSTGSTVTIKGRPLVCFLNEPYLQVDFHTEMKEESDIVFHFQVCFGR
RVVMNSREYGAWKQQVESKNMPFQDGQEFELSISVLPDKYQVMVNGQSSYTFDHRIKPEA
VKMVQVWRDISLTKFNVSYLKR

# Metabolic_Enzyme_7_Number_of_Residues:
142

# Metabolic_Enzyme_7_Molecular_Weight:
16481

# Metabolic_Enzyme_7_Theoretical_pI:
7.50

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
May have both lysophospholipase and carbohydrate-binding activities

# Metabolic_Enzyme_7_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_7_Reaction:
2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00337:Gal-bind_lectin

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.1.1.5

# Metabolic_Enzyme_7_GenBank_ID_Protein:
187274

# Metabolic_Enzyme_7_SwissProt_ID:
LPPL_HUMAN (Q05315)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
CLC

# Metabolic_Enzyme_7_Geneatlas_id:
CLC

# Metabolic_Enzyme_7_hgnc_id:
HGNC:2014

# Metabolic_Enzyme_7_PDB_ID:
1QKQ

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Note=Localized in granules from where it may be secreted or transported to other locations in the cell

# Metabolic_Enzyme_7_Gene_Sequence:
>429 bp
ATGTCCCTGCTACCCGTGCCATACACAGAGGCTGCCTCTTTGTCTACTGGTTCTACTGTG
ACAATCAAAGGGCGACCACTTGTCTGTTTCTTGAATGAACCATATCTGCAGGTGGATTTC
CACACTGAGATGAAGGAGGAATCAGACATTGTCTTCCATTTCCAAGTGTGCTTTGGTCGT
CGTGTGGTCATGAACAGCCGTGAGTATGGGGCCTGGAAGCAGCAGGTGGAATCCAAGAAC
ATGCCCTTTCAGGATGGCCAAGAATTTGAACTGAGCATCTCAGTGCTGCCAGATAAGTAC
CAGGTAATGGTCAATGGCCAATCCTCTTACACCTTTGACCATAGAATCAAGCCTGAGGCT
GTGAAGATGGTGCAAGTGTGGAGAGATATCTCCCTGACCAAATTTAATGTCAGCTATTTA
AAGAGATAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
L01664

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_7_Locus:
19q13.1

# Metabolic_Enzyme_7_SNPs:
rs17608; rs384138; rs44049; rs400233; rs367788; rs2238678; rs395892; rs44048; rs364911; rs373449; rs2074926; rs385520; rs446425; rs372902; rs391660; rs7253094; rs396854; rs1985359; rs367529; rs378917; rs437780; rs399641; rs372081; rs385288; rs444963; rs12611412; rs453827; rs383768; rs17709471; rs385240; rs10402365; rs389708; rs375867; rs388648; rs444817; rs391646; rs367156; rs395969; rs390406; rs414423; rs4802054; rs420297; rs2074928; rs431329; rs407640; rs447034; rs425218; rs428007; rs12611334; rs440191; rs7248113; rs7248344; rs7260274; rs425265; rs412211; rs413216; rs1034995; rs12463284; rs375688; rs10407799; rs7249415; rs7249847; rs12977184; rs12977467; rs34365053; rs34895925; rs12978411; rs12978659; rs12978243; rs104734; rs10636410; rs28439433; rs10636409; rs7249381; rs36043907; rs368009; rs34256647; rs34848185; rs34788009; rs2074927; rs375580; rs34953733; rs34190066; rs12980270; rs10408284; rs12979750; rs391333; rs444844; rs7249657; rs9676700; rs12978155; rs12979261; rs35837917; rs28595535; rs2159137; rs403831; rs7260191; rs2108685; rs5828049; rs1034996; rs7258913; rs8101720; rs35110762; rs1034867; rs1034868; rs10402500; rs10409161; rs10421474; rs10422830; rs16973596; rs2108686; rs2355335; rs385563; rs385895; rs410034; rs412884; rs4141230; rs4141231; rs418664; rs440334

# Metabolic_Enzyme_7_General_References:
8419478; 1577491; 9119387; 8747464; 10529229

# Metabolic_Enzyme_7_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
5297

# Macromolecular_Interacting_Partner_1_Name:
85 kDa calcium-independent phospholipase A2

# Macromolecular_Interacting_Partner_1_Synonyms:
iPLA2; CaI- PLA2; Group VI phospholipase A2; GVI PLA2

# Macromolecular_Interacting_Partner_1_Gene_Name:
PLA2G6

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>85 kDa calciumindependent phospholipase A2
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLV
NPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSW
SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD
VTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL
LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA
RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK
DNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHG
VPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTHDHL
LCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGM
YFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFR
NYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNP
TLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKT
VFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVN
ALWETEVYIYEHREEFQKLIQLLLSP

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
806

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
89904

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.28

# Macromolecular_Interacting_Partner_1_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity

# Macromolecular_Interacting_Partner_1_Pathway:
map00564  Glycerophospholipid metabolism;
 map00590  Prostaglandin and leukotriene metabolism

# Macromolecular_Interacting_Partner_1_Reaction:
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00023:Ank

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 3.1.1.4

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
3142700

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
PA2G6_HUMAN (O60733)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
PLA2G6

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
PLA2G6

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9039

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Isoform LH-iPLA2:Membrane; peripheral membrane protein. Isoform SH-iPLA2:Cytoplasm

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>2421 bp
ATGCAGTTCTTTGGCCGCCTGGTCAATACCTTCAGTGGCGTCACCAACTTGTTCTCTAAC
CCATTCCGGGTGAAGGAGGTGGCTGTGGCCGACTACACCTCGAGTGACCGAGTTCGGGAG
GAAGGGCAGCTGATTCTGTTCCAGAACACTCCCAACCGCACCTGGGACTGCGTCCTGGTC
AACCCCAGGAACTCACAGAGTGGATTCCGACTCTTCCAGCTGGAGTTGGAGGCTGACGCC
CTAGTGAATTTCCATCAGTATTCTTCCCAGCTGCTACCCTTCTATGAGAGCTCCCCTCAG
GTCCTGCACACTGAGGTCCTGCAGCACCTGACCGACCTCATCCGTAACCACCCCAGCTGG
TCAGTGGCCCACCTGGCTGTGGAGCTAGGGATCCGCGAGTGCTTCCATCACAGCCGTATC
ATCAGCTGTGCCAATTGCGCGGAGAACGAGGAGGGCTGCACACCCCTGCACCTGGCCTGC
CGCAAGGGTGATGGGGAGATCCTGGTGGAGCTGGTGCAGTACTGCCACACTCAGATGGAT
GTCACCGACTACAAGGGAGAGACCGTCTTCCATTATGCTGTCCAGGGTGACAATTCTCAG
GTGCTGCAGCTCCTTGGAAGGAACGCAGTGGCTGGCCTGAACCAGGTGAATAACCAAGGG
CTGACCCCGCTGCACCTGGCCTGCCAGCTGGGGAAGCAGGAGATGGTCCGCGTGCTGCTG
CTGTGCAATGCTCGGTGCAACATCATGGGCCCCAACGGCTACCCCATCCACTCGGCCATG
AAGTTCTCTCAGAAGGGGTGTGCGGAGATGATCATCAGCATGGACAGCAGCCAGATCCAC
AGCAAAGACCCCCGTTACGGAGCCAGCCCCCTCCACTGGGCCAAGAACGCAGAGATGGCC
CGCATGCTGCTGAAACGGGGCTGCAACGTGAACAGCACCAGCTCCGCGGGGAACACGGCC
CTGCACGTGGCGGTGATGCGCAACCGCTTCGACTGTGCCATAGTGCTGCTGACCCACGGG
GCCAACGCGGATGCCCGCGGAGAGCACGGCAACACCCCGCTGCACCTGGCCATGTCGAAA
GACAACGTGGAGATGATCAAGGCCCTCATCGTGTTCGGAGCAGAAGTGGACACCCCGAAT
GACTTTGGGGAGACTCCTACATTCCTAGCCTCCAAAATCGGCAGACTTGTCACCAGGAAG
GCGATCTTGACTCTGCTGAGAACCGTGGGGGCCGAATACTGCTTCCCACCCATCCACGGG
GTCCCCGCGGAGCAGGGCTCTGCAGCGCCACATCATCCCTTCTCCCTGGAAAGAGCTCAG
CCCCCACCGATCAGCCTAAACAACCTAGAACTACAGGATCTCATGCACATCTCACGGGCC
CGGAAGCCAGCGTTCATCCTGGGCTCCATGAGGGACGAGAAGCGGACCCACGACCACCTG
CTGTGCCTGGATGGAGGAGGAGTGAAAGGCCTCATCATCATCCAGCTCCTCATCGCCATC
GAGAAGGCCTCGGGTGTGGCCACCAAGGACCTGTTTGACTGGGTGGCGGGCACCAGCACT
GGAGGCATCCTGGCCCTGGCCATTCTGCACAGTAAGTCCATGGCCTACATGCGCGGCATG
TACTTTCGCATGAAGGATGAGGTGTTCCGGGGCTCCAGGCCCTACGAGTCGGGGCCCCTG
GAGGAGTTCCTGAAGCGGGAGTTTGGGGAGCACACCAAGATGACGGACGTCAGGAAACCC
AAGGTGATGCTGACAGGGACACTGTCTGACCGGCAGCCGGCTGAACTCCACCTCTTCCGG
AACTACGATGCTCCAGAAACTGTCCGGGAGCCTCGTTTCAACCAGAACGTTAACCTCAGG
CCTCCAGCTCAGCCCTCAGACCAGCTGGTGTGGCGGGCGGCCCGAAGCAGCGGGGCAGCT
CCTACTTACTTCCGACCCAATGGGCGCTTCCTGGACGGTGGGCTGCTGGCCAACAACCCC
ACGCTGGATGCCATGACCGAGATCCATGAGTACAATCAGGACCTGATCCGCAAGGGTCAG
GCCAACAAGGTGAAGAAACTCTCCATCGTTGTCTCCCTGGGGACAGGGAGGTCCCCACAA
GTGCCTGTGACCTGTGTGGATGTCTTCCGTCCCAGCAACCCCTGGGAGCTGGCCAAGACT
GTTTTTGGGGCCAAGGAACTGGGCAAGATGGTGGTGGACTGTTGCACGGATCCAGACGGG
CGGGCTGTGGACCGGGCACGGGCCTGGTGCGAGATGGTCGGCATCCAGTACTTCAGATTG
AACCCCCAGCTGGGGACGGACATCATGCTGGATGAGGTCAGTGACACAGTGCTGGTCAAC
GCCCTCTGGGAGACCGAGGTCTACATCTATGAGCACCGCGAGGAGTTCCAGAAGCTCATC
CACCTGCTGCTCTCACCCTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AF064594

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_1_Locus:
22q13.1

# Macromolecular_Interacting_Partner_1_SNPs:
rs11570606; rs11570680; rs11570605; rs2413502; rs11570679; rs2267369; rs4384; rs2267371; rs133029; rs133006; rs2277844; rs2267370; rs738322; rs133007; rs4378; rs2413503; rs133009; rs738321; rs738320; rs132991; rs4379; rs133012; rs132989; rs9610911; rs133017; rs133014; rs132995; rs132998; rs11570601; rs738323; rs6001045; rs133019; rs9306323; rs4380; rs2092180; rs133008; rs133013; rs133015; rs132999; rs9610910; rs4385; rs132992; rs75387; rs133016; rs132994; rs133021; rs4381; rs4382; rs133018; rs11570598; rs132993; rs133001; rs133022; rs132996; rs5756947; rs6001037; rs133003; rs11570602; rs4820318; rs8142004; rs132997; rs4383; rs6001038; rs133023; rs4820320; rs11570599; rs6001040; rs16998801; rs11570603; rs133024; rs132985; rs132966; rs2076112; rs2016755; rs731821; rs9619724; rs2076118; rs5750542; rs6001030; rs132946; rs84473; rs1807559; rs4987198; rs6001029; rs4820314; rs2005974; rs4821751; rs2284066; rs6001034; rs4821740; rs3827354; rs6001031; rs3788535; rs3891103; rs2267367; rs2235346; rs8135333; rs7286105; rs5756921; rs4375; rs2284062; rs3788532; rs4820317; rs6001020; rs2076116; rs2076113; rs6001026; rs6001014; rs2012725; rs2235345; rs6001033; rs5756931; rs4821746; rs5756940; rs2235347; rs3788536; rs1807712; rs5750546; rs3788533; rs2267368; rs132954; rs5756922; rs2076117; rs11570645; rs9622746; rs6001028; rs6001022; rs132976; rs738317; rs4376; rs5756934; rs132941; rs6001027; rs2284059; rs8135937; rs2076115; rs11570753; rs132972; rs11570734; rs2272831; rs11570641; rs4497; rs736129; rs132979; rs11089864; rs11570681; rs5995538; rs132987; rs11570736; rs11570651; rs11570658; rs2284063; rs132988; rs6001018; rs132977; rs4377; rs11570682; rs11089868; rs132975; rs132944; rs3900948; rs4821741; rs2235344; rs6001023; rs4821747; rs2018663; rs3788534; rs2072867; rs11570724; rs11570761; rs132973; rs3827355; rs4987197; rs11570710; rs5750547; rs10427700; rs132953; rs11570678; rs11570666; rs6001021; rs11570647; rs10483197; rs6001035; rs2284067; rs5756926; rs5750549; rs5756932; rs6001015; rs132960; rs11570690; rs5756929; rs2076114; rs4820315; rs132986; rs2284060; rs12485185; rs132952; rs11570649; rs132959; rs9622732; rs7290177; rs11570608; rs11570739; rs11570762; rs11570717; rs10427916; rs11570737; rs132964; rs11570701; rs11570721; rs11570660; rs132969; rs9622738; rs11570670; rs11570744; rs12167576; rs132982; rs11570683; rs11266975; rs5995542; rs9622743; rs2284061; rs132978; rs5750548; rs11570750; rs11570707; rs11570687; rs11570667; rs11089869; rs6001036; rs5750544; rs132974; rs11570751; rs11570727; rs11570630; rs11913405; rs132984; rs11570639; rs4821742; rs11570732; rs11570635; rs5756933; rs4820316; rs5756930; rs11912233; rs11570674; rs11570677; rs11570609; rs10427908; rs2284065; rs11570715; rs11570748; rs11704062; rs11570730; rs133010; rs2179236; rs11570662; rs4821743; rs132970; rs11570714; rs6001019; rs16998769; rs11570726; rs11570657; rs11570713; rs11570614; rs16998759; rs11570745; rs5750543; rs4987199; rs11570709; rs11570672; rs11570696; rs11570700; rs11570668; rs11570722; rs16998753; rs11570747; rs11570728; rs11570684; rs11570638; rs132939; rs11913898; rs7284662; rs1005529; rs17563060; rs11570718; rs11570665; rs9610908; rs132971; rs16998755; rs11089865; rs132965; rs11570611; rs11570716; rs11570733; rs11570749; rs11570624; rs4821749; rs5756946; rs9610907; rs1005528; rs11570663; rs11570669; rs11089863; rs5750541; rs11570659; rs132945; rs11570640; rs2281108; rs6001017; rs2284064; rs11570719; rs11570634; rs11570653; rs11570620; rs4821748; rs11570702; rs11570711; rs6001032; rs132950; rs11089870; rs4821753; rs4820321; rs4821752; rs5995543; rs5750556; rs11570590; rs11570589; rs12157473; rs11570646; rs11570607; rs12627857; rs8142389; rs11570604; rs8137578; rs133020; rs36014862; rs35804966; rs2413504; rs34718565; rs133027; rs34139192; rs34365126; rs132990; rs735336; rs133000; rs34190594; rs35260453; rs133025; rs28565947; rs35526737; rs28653361; rs28718653; rs11570597; rs28421906; rs34856995; rs133005; rs11570600; rs2142838; rs133028; rs34809384; rs35231946; rs9607514; rs133004; rs35950199; rs34292639; rs133026; rs133002; rs28428653; rs35530438; rs133011; rs11471646; rs11570697; rs11570673; rs11570618; rs7291586; rs35501048; rs11570699; rs8142930; rs9610905; rs11570689; rs28719740; rs11570626; rs34701842; rs11570694; rs35313235; rs11570757; rs11570656; rs8140579; rs5756920; rs11570637; rs12329956; rs8140454; rs34536395; rs10543970; rs132943; rs11570725; rs132962; rs5995540; rs132956; rs34174459; rs9607512; rs28460110; rs11570616; rs132967; rs11704969; rs11570685; rs11570615; rs132980; rs12162857; rs12162828; rs8141149; rs35709752; rs12165507; rs2235343; rs12167913; rs11570621; rs11441204; rs9610906; rs34612391; rs6001013; rs11570729; rs11570623; rs11570691; rs9610909; rs11570706; rs35883426; rs11570756; rs11570631; rs11570664; rs28695983; rs11570610; rs5845373; rs11570741; rs11570654; rs132937; rs132949; rs11570712; rs5756927; rs10709435; rs11570743; rs11570703; rs9610904; rs34951630; rs6001016; rs34848813; rs11570758; rs35736012; rs11570693; rs34164997; rs11570628; rs11570704; rs12169611; rs11570619; rs5750554; rs11570652; rs11570642; rs34471882; rs5845371; rs2281107; rs7511015; rs132948; rs5756925; rs132935; rs35449261; rs11570661; rs34143772; rs34550422; rs9619722; rs11570612; rs132958; rs11570648; rs9622739; rs11570671; rs35897756; rs11570650; rs5845374; rs11570752; rs4521147; rs11570695; rs11570686; rs34896234; rs132961; rs9622729; rs11570644; rs34944600; rs11570688; rs11570617; rs35195613; rs11570698; rs11913581; rs132981; rs132951; rs12168078; rs11570633; rs11570754; rs5995541; rs11570731; rs132983; rs35205726; rs35928089; rs132942; rs28366733; rs35103228; rs41274545; rs11570738; rs132938; rs10427716; rs11308495; rs35120028; rs132968; rs34478021; rs11570759; rs5845372; rs35606878; rs11570625; rs35795447; rs9607513; rs9622727; rs35440920; rs35948405; rs11570742; rs5995539; rs132947; rs132936; rs36103241; rs5750551; rs11570632; rs35214564; rs35737378; rs132955; rs11570723; rs4610161; rs9622731; rs12165464; rs11570705; rs9622745; rs11570735; rs11570760; rs12484261; rs11570643; rs11570675; rs5756924; rs13054568; rs35788613; rs132957; rs132940; rs34184783; rs5995537; rs5756919; rs11570613; rs11570622; rs11570692; rs36110979; rs11442770; rs11570740; rs132963; rs34379826; rs35337783; rs11570708; rs34566636; rs7290683; rs11570629; rs11570755; rs11570592; rs11570591; rs11570594; rs12167142; rs12167111; rs35918994; rs2142729; rs11570593; rs13054001; rs11570595; rs5756950; rs11570596; rs34482513; rs34112430; rs11089861; rs11570773; rs12484232; rs13055413; rs34184838; rs4296527; rs4820313; rs4821737; rs4821738; rs4821754; rs5756914; rs5756916; rs5995544; rs6001007; rs6001008; rs6001009; rs8140036; rs9306324; rs9622726

# Macromolecular_Interacting_Partner_1_General_References:
9417066; 10092647; 10336645; 10591208

# Macromolecular_Interacting_Partner_1_References:
10395967; 11041281; 9453575

# Macromolecular_Interacting_Partner_2_ID:
5922

# Macromolecular_Interacting_Partner_2_Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4A

# Macromolecular_Interacting_Partner_2_Synonyms:
DPDE2; PDE46

# Macromolecular_Interacting_Partner_2_Gene_Name:
PDE4A

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>cAMPspecific 3',5'cyclic phosphodiesterase 4
AMEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERER
QPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPG
RSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVT
PFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELD
WCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVE
IPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKT
DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM
LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG
VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVID
MVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPL
ELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD
LVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE
EISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYL
TQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGL
PSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
886

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
98144

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
4.87

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate

# Macromolecular_Interacting_Partner_2_Pathway:
map00230  Purine metabolism

# Macromolecular_Interacting_Partner_2_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00233:PDEase_I

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
EC 3.1.4.17

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
347120

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
PDE4A_HUMAN (P27815)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
PDE4A

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
PDE4A

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:8780

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Isoform 4:Membrane; peripheral membrane protein. Note=Isoform 4 has propensity for association with membranes

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>2661 bp
ATGGAACCCCCGACCGTCCCCTCGGAAAGGAGCCTGTCTCTGTCACTGCCCGGGCCCCGG
GAGGGCCAGGCCACCCTGAAGCCTCCCCCGCAGCACCTGTGGCGGCAGCCTCGGACCCCC
ATCCGTATCCAGCAGCGCGGCTACTCCGACAGCGCGGAGCGCGCCGAGCGGGAGCGGCAG
CCGCACCGGCCCATAGAGCGCGCCGATGCCATGGACACCAGCGACCGGCCCGGCCTGCGC
ACGACCCGCATGTCCTGGCCCTCGTCCTTCCATGGCACTGGCACCGGCAGCGGCGGCGCG
GGCGGAGGCAGCAGCAGGCGCTTCGAGGCAGAGAATGGGCCGACACCATCTCCTGGCCGC
AGCCCCCTGGACTCGCAGGCGAGCCCAGGACTCGTGCTGCACGCCGGGGCGGCCACCAGC
CAGCGCCGGGAGTCCTTCCTGTACCGCTCAGACAGCGACTATGACATGTCACCCAAGACC
ATGTCCCGGAACTCATCGGTCACCAGCGAGGCGCACGCTGAAGACCTCATCGTAACACCA
TTTGCTCAGGTGCTGGCCAGCCTCCGGAGCGTCCGTAGCAACTTCTCACTCCTGACCAAT
GTGCCCGTTCCCAGTAACAAGCGGTCCCCGCTGGGCGGCCCCACCCCTGTCTGCAAGGCC
ACGCTGTCAGAAGAAACGTGTCAGCAGTTGGCCCGGGAGACTCTGGAGGAGCTGGACTGG
TGTCTGGAGCAGCTGGAGACCATGCAGACCTATCGCTCTGTCAGCGAGATGGCCTCGCAC
AAGTTCAAAAGGATGTTGAACCGTGAGCTCACACACCTGTCAGAAATGAGCAGGTCCGGA
AACCAGGTCTCAGAGTACATTTCCACAACATTCCTGGACAAACAGAATGAAGTGGAGATC
CCATCACCCACGATGAAGGAACGAGAAAAACAGCAAGCGCCGCGACCAAGACCCTCCCAG
CCGCCCCCGCCCCCTGTACCACACTTACAGCCCATGTCCCAAATCACAGGGTTGAAAAAG
TTGATGCATAGTAACAGCCTGAACAACTCTAACATTCCCCGATTTGGGGTGAAGACCGAT
CAAGAAGAGCTCCTGGCCCAAGAACTGGAGAACCTGAACAAGTGGGGCCTGAACATCTTT
TGCGTGTCGGATTACGCTGGAGGCCGCTCACTCACCTGCATCATGTACATGATATTCCAG
GAGCGGGACCTGCTGAAGAAATTCCGCATCCCGGTGGACACGATGGTGACATACATGCTG
ACGCTGGAGGATCACTACCACGCTGACGTGGCCTACCATAACAGCCTGCACGCAGCTGAC
GTGCTGCAGTCCACCCACGTACTGCTGGCCACGCCTGCACTAGATGCAGTGTTCACGGAC
CTGGAGATTCTCGCCGCCCTCTTCGCGGCTGCCATCCACGATGTGGATCACCCTGGGGTC
TCCAACCAGTTCCTCATCAACACCAATTCGGAGCTGGCGCTCATGTACAACGATGAGTCG
GTGCTCGAGAATCACCACCTGGCCGTGGGCTTCAAGCTGCTGCAGGAGGACAACTGCGAC
ATCTTCCAGAACCTCAGCAAGCGCCAGCGGCAGAGCCTACGCAAGATGGTCATCGACATG
GTGCTGGCCACGGACATGTCCAAGCACATGACCCTCCTGGCTGACCTGAAGACCATGGTG
GAGACCAAGAAAGTGACCAGCTCAGGGGTCCTCCTGCTAGATAACTACTCCGACCGCATC
CAGGTCCTCCGGAACATGGTGCACTGTGCCGACCTCAGCAACCCCACCAAGCCGCTGGAG
CTGTACCGCCAGTGGACAGACCGCATCATGGCCGAGTTCTTCCAGCAGGGTGACCGAGAG
CGCGAGCGTGGCATGGAAATCAGCCCCATGTGTGACAAGCACACTGCCTCCGTGGAGAAG
TCTCAGGTGGGTTTTATTGACTACATTGTGCACCCATTGTGGGAGACCTGGGCGGACCTT
GTCCACCCAGATGCCCAGGAGATCTTGGACACTTTGGAGGACAACCGGGACTGGTACTAC
AGCGCCATCCGGCAGAGCCCATCTCCGCCACCCGAGGAGGAGTCAAGGGGGCCAGGCCAC
CCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGAA
ATATCAATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCA
GGAGTCGAGGAAGCTCTGGATGCAACCATAGCCTGGGAGGCATCCCCGGCCCAGGAGTCG
TTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGACA
CAGCAGGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAG
GAATTCGTGGTTGCTGTAAGCCACAGCAGCCCCTCTGCCCTGGCTCTTCAAAGCCCCCTT
CTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCCC
TCCACGGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGT
GCCTGCGCAGGGACATTTGGGGAGGACACATCCGCACTCCCAGCTCCTGGTGGCGGGGGG
TCAGGTGGAGACCCTACCTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
L20965

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_2_Locus:
19p13.2

# Macromolecular_Interacting_Partner_2_SNPs:
rs1051738; rs2230190; rs2230189; rs7256672; rs3745258; rs4804134; rs2358681; rs10416143; rs7247481; rs7343073; rs1194098; rs11672021; rs1051736; rs3192116; rs35473931; rs35610871; rs3745260; rs3192124; rs3833220; rs7253115; rs12985883; rs3745259; rs34212445; rs2569755; rs35371416; rs12983959; rs2569756; rs2735389; rs5827100; rs11666164; rs10404367; rs12975524; rs34214178; rs35888394; rs10411816; rs34675916; rs12610073; rs35398762; rs34222169; rs33984348; rs34278258; rs35452057; rs12975511; rs34861232; rs12981823; rs12982685; rs1194097; rs4804504; rs35757023; rs12982917; rs35214617; rs34230915; rs4804503; rs35368894; rs12981546; rs12975530; rs3936362; rs35867809; rs2735390; rs10423080; rs2569758; rs2569765; rs12978292; rs2569766; rs12978315; rs2569757; rs2569763; rs12978301; rs2569759; rs2569761; rs12978366; rs2569764; rs2569762; rs12978582; rs2569760; rs12980133; rs35084366; rs12980191; rs12981218; rs35715070; rs34519818; rs35937838; rs10416653; rs11671269; rs2569767; rs2569768; rs4804505; rs8105602

# Macromolecular_Interacting_Partner_2_General_References:
8413254; 9677330; 2160582; 7772058; 7888306

# Macromolecular_Interacting_Partner_2_References:
1652765; 3667610

# Macromolecular_Interacting_Partner_3_ID:
8051

# Macromolecular_Interacting_Partner_3_Name:
14-3-3 protein zeta/delta

# Macromolecular_Interacting_Partner_3_Synonyms:
Protein kinase C inhibitor protein 1; KCIP-1

# Macromolecular_Interacting_Partner_3_Gene_Name:
YWHAZ

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>1433 protein zeta/delta
MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWR
VVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLK
MKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYE
ILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAG
EGGEN

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
245

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
27745

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
4.43

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  protein domain specific binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00244:14-3-3

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
EC 3.1.1.4

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
189953

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
1433Z_HUMAN (P63104)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
YWHAZ

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
YWHAZ

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:12855

# Macromolecular_Interacting_Partner_3_PDB_ID:
1QJA

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>738 bp
ATGGATAAAAATGAGCTGGTTCAGAAGGCCAAACTGGCCGAGCAGGCTGAGCGATATGAT
GACATGGCAGCCTGCATGAAGTCTGTAACTGAGCAAGGAGCTGAATTATCCAATGAGGAG
AGGAATCTTCTCTCAGTTGCTTATAAAAATGTTGTAGGAGCCCGTAGGTCATCTTGGAGG
GTCGTCTCAAGTATTGAACAAAAGACGGAAGGTGCTGAGAAAAAACAGCAGATGGCTCGA
GAATACAGAGAGAAAATTGAGACGGAGCTAAGAGATATCTGCAATGATGTACTGTCTCTT
TTGGAAAAGTTCTTGATCCCCAATGCTTCACAAGCAGAGAGCAAAGTCTTCTATTTGAAA
ATGAAAGGAGATTACTACCGTTACTTGGCTGAGGTTGCCGCTGGTGATGACAAGAAAGGG
ATTGTCGATCAGTCACAACAAGCATACCAAGAAGCTTTTGAAATCAGCAAAAAGGAAATG
CAACCAACACATCCTATCAGACTGGGTCTGGCCCTTAACTTCTCTGTGTTCTATTATGAG
ATTCTGAACTCCCCAGAGAAAGCCTGCTCTCTTGCAAAGACAGCTTTTGATGAAGCCATT
GCTGAACTTGATACATTAAGTGAAGAGTCATACAAAGACAGCACGCTAATAATGCAATTA
CTGAGAGACAACTTGACATTGTGGACATCGGATACCCAAGGAGACGAAGCTGAAGCAGGA
GAAGGAGGGGAAAATTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
M86400

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:8

# Macromolecular_Interacting_Partner_3_Locus:
8q23.1

# Macromolecular_Interacting_Partner_3_SNPs:
rs983583; rs1062382; rs11551356; rs2290291; rs1470764; rs3134380; rs3100053; rs1901362; rs964917; rs3134358; rs6996921; rs3134353; rs4734497; rs3105460; rs11993430; rs10103987; rs10505003; rs17366009; rs1376672; rs17365661; rs17365948; rs17365305; rs4734499; rs3134359; rs17365982; rs3100054; rs17462753; rs3105452; rs17462921; rs17462718; rs17463116; rs3134352; rs4734498; rs17462648; rs3134377; rs7835096; rs3735706; rs17365578; rs17365808; rs6468746; rs17366086; rs3134354; rs17463451; rs17366023; rs17462991; rs3134376; rs6468745; rs6983989; rs3735704; rs3757877; rs3100052; rs3832540; rs11551365; rs34886798; rs41473144; rs1062393; rs3921614; rs1827729; rs1062376; rs4106220; rs4003437; rs1062387; rs11551354; rs4003438; rs11545396; rs11551357; rs1139382; rs10098502; rs1451637; rs34971556; rs34072712; rs4085567; rs3956010; rs4003432; rs34422564; rs34531415; rs35225207; rs10091218; rs36113483; rs34478072; rs35220059; rs34422675; rs35069019; rs34722786; rs34307024; rs35286878; rs34965557; rs10103744; rs41530446; rs35221212; rs33984830; rs3134356; rs964919; rs35083016; rs41381451; rs3134379; rs34944144; rs34699406; rs41433245; rs28410105; rs34861164; rs34687434; rs35638759; rs12675915; rs3134355; rs4422749; rs41507849; rs34865637; rs41336048; rs11783216; rs11398423; rs34477209; rs35655511; rs34319976; rs34777114; rs34540560; rs5893539; rs34054353; rs41368551; rs3077263; rs41494944; rs41361446; rs12676840; rs35893445; rs5893538; rs35075569; rs3077262; rs35693484; rs41408945; rs35628844; rs34238026; rs3203463; rs34061524; rs10700485; rs13254653; rs2386922; rs3019275; rs4734500; rs7010668; rs7846397

# Macromolecular_Interacting_Partner_3_General_References:
1577711; 9512661; 12665801; 10488331

# Macromolecular_Interacting_Partner_3_References:
10395967; 1415720; 2116482; 7751812

# Macromolecular_Interacting_Partner_4_ID:
8433

# Macromolecular_Interacting_Partner_4_Name:
Phospholipase C

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
PLCL1

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Phospholipase 
CMPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAK
LDISAIKEIRLGKNTETFTNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSG
LRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKE
AKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLML
FLEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVA
QDMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILC
NRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYT
EAPLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAQMSRRMSVDYNGEQK
QIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKK
FLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRP
SIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGI
PADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFE
CLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRN
IGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSSRLITS
DNTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKIVQCQK
AGMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENMKQIQL
ACLSCGLSKAPSSSAEAKSKRSLEAIEEKESSEENGKL

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
997

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
112957

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
5.26

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  carboxylic ester hydrolase activity
Function:  lipase activity
Function:  phospholipase activity
Function:  phospholipase C activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  inositol or phosphatidylinositol phosphodiesterase activity
Function:  phosphoinositide phospholipase C activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  intracellular signaling cascade
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00168:C2;
PF00169:PH;
PF00388:PI-PLC-X;
PF00387:PI-PLC-Y

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
780122

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
Q15111_HUMAN (Q15111)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
PLCL1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
PLCL1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:9063

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>2994 bp
ATGCCATCGGAAAAGAAAATTAGCAGTGCAAATGACTGCATCAGCTTCATGCAAGCTGGC
TGTGAGTTGAAGAAAGTCCGGCCAAATTCTCGCATTTACAACCGTTTTTTCACTCTGGAC
ACAGACCTTCAAGCTCTTCGCTGGGAACCTTCAAAGAAAGACCTCGAGAAAGCCAAGCTT
GATATTTCTGCCATAAAAGAGATCAGACTGGGGAAAAACACGGAAACATTTACAAACAAT
GGCCTTGCTGACCAGATCTGTGAGGACTGTGCCTTTTCCATACTCCACGGGGAAAACTAT
GAGTCTCTGGACCTAGTTGCCAATTCAGCAGATGTGGCAAACATCTGGGTGTCTGGGTTA
CGGTACCTGGTTTCTCGAAGTAAGCAGCCTCTTGATTTTATGGAGGGCAACCAGAACACA
CCACGGTTCATGTGGTTGAAAACAGTGTTTGAAGCAGCAGATGTTGATGGGAATGGGATT
ATGTTGGAAGACACCTCTGTAGAGTTAATAAAACAACTCAACCCTACTCTGAAGGAAGCC
AAGATCAGGTTAAAGTTTAAAGAAATCCAGAAGAGCAAGGAAAAACTAACCACCCGCGTG
ACCGAAGAGGAATTTTGTGAAGCTTTTTGTGAACTTTGCACCAGGCCAGAAGTGTATTTC
TTACTTGTACAGATATCTAAAAACAAAGAATATTTGGATGCCAATGATCTCATGCTCTTT
TTAGAAGCTGAGCAAGGAGTCACCCATATCACCGAGGATATATGCTTAGACATCATAAGG
AGATACGAACTTTCTGAAGAGGGACGTCAAAAAGGGTTTCTTGCAATTGATGGCTTTACC
CAGTATTTATTGTCATCAGAATGTGACATTTTTGATCCTGAGCAAAAGAAGGTTGCCCAA
GATATGACCCAGCCATTATCTCACTACTATATCAATGCCTCTCATAACACCTATCTAATA
GAAGACCAGTTCAGGGGGCCAGCTGACATCAATGGGTACATTAGAGCTTTGAAAATGGGC
TGTCGAAGCGTTGAACTCGATGTAAGTGATGGTTCAGATAATGAACCAATCCTTTGTAAT
CGAAATAACATGACAACCCATGTTTCCTTTCGAAGTGTCATAGAGGTAATAAATAAATTT
GCCTTTGTTGCTTCTGAATACCCACTCATTCTTTGCTTGGGAAATCACTGCTCCTTGCCG
CAGCAGAAGGTAATGGCTCAACAGATGAAAAAGGTCTTTGGCAATAAACTCTATACTGAA
GCACCTTTGCCCTCAGAATCCTACCTCCCATCACCAGAAAAATTAAAAAGAATGATCATT
GTGAAAGGAAAGAAGTTGCCTTCTGATCCAGATGTGTTAGAAGGAGAAGTAACAGATGAA
GATGAAGAAGCTCAAATGTCTCGAAGGATGTCGGTAGATTACAATGGTGAGCAGAAGCAA
ATCCGACTCTGTAGGGAGCTCTCTGATTTGGTGTCTATTTGTAAATCTGTTCAATACAGG
GATTTTGAACTATCTATGAAAAGCCAAAACTATTGGGAAATGTGTTCATTTAGTGAAACA
GAGGCCAGCCGCATTGCAAATGAGTACCCAGAGGATTTTGTTAATTATAATAAGAAGTTC
TTATCAAGAATCTATCCAAGTGCCATGAGGATCGATTCCAGTAACTTGAATCCACAGGAC
TTTTGGAATTGTGGCTGTCAGATTGTAGCAATGAATTTTCAGACTCCGGGTCCAATGATG
GACCTTCACACGGGCTGGTTTCTTCAAAACGGGGGATGTGGTTATGTTCTAAGGCCGTCT
ATAATGCGAGATGAAGTTTCTTACTTCAGCGCAAATACAAAGGGCATTCTACCTGGGGTG
TCTCCTCTAGCTCTTCATATCAAGATCATCAGTGGTCAGAATTTCCCAAAGCCCAAGGGA
GCTTGTGCCAAAGGGGATGTCATAGATCCCTATGTTTGTATAGAGATACACGGAATTCCA
GCGGATTGTTCGGAACAAAGAACTAAAACTGTACAGCAAAACAGTGATAATCCTATTTTT
GATGAAACTTTTGAGTTCCAAGTAAACCTACCTGAGCTGGCCATGATCCGTTTTGTTGTT
CTGGATGATGACTACATTGGGGATGAGTTTATAGGGCAATATACGATACCATTTGAATGT
TTGCAGCCTGGATATCGGCATGTTCCCCTGCGTTCTTTTGTGGGTGACATCATGGAGCAC
GTAACCCTTTTTGTCCACATAGCAATAACTAATCGAAGTGGAGGAGGAAAGGCACAGAAG
CGCAGTCTTTCAGTGAGAATGGGGAAGAAAGTTCGGGAATATACCATGCTCAGGAATATC
GGTCTTAAAACCATTGATGACATCTTTAAAATAGCGGTTCATCCATTACGAGAAGCCATA
GATATGAGAGAAAATATGCAGAATGCAATCGTGTCTATTAAGGAACTATGTGGACTCCCT
CCAATTGCCAGTCTGAAGCAGTGCCTGTTAACTCTGTCATCTCGGCTCATCACCAGTGAC
AATACTCCTTCAGTCTCACTTGTGATGAAAGACAGCTTTCCTTACCTGGAGCCTCTGGGT
GCAATTCCAGATGTGCAGAAAAAGATGCTGACTGCTTATGATCTGATGATTCAAGAGAGC
CGGTTTCTCATAGAAATGGCGGACACAGTCCAGGAAAAGATTGTACAGTGTCAGAAAGCA
GGGATGGAGTTCCATGAAGAACTTCATAATTTGGGGGCAAAAGAAGGCTTGAAGGGAAGA
AAACTCAACAAAGCAACTGAGAGCTTTGCTTGGAACATTACAGTATTGAAGGGCCAAGGA
GATCTGTTGAAGAATGCCAAGAATGAAGCTATAGAAAACATGAAGCAGATCCAGCTGGCA
TGCCTGTCCTGTGGACTGAGTAAAGCCCCCAGCAGCAGTGCTGAGGCCAAGAGCAAGCGC
AGCCTGGAAGCCATAGAGGAGAAGGAAAGTAGTGAGGAGAATGGGAAGCTGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
D42108

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_4_Locus:
2q33

# Macromolecular_Interacting_Partner_4_SNPs:
rs1064213; rs2228135; rs745899; rs1318867; rs1440090; rs1813106; rs1866666; rs1866664; rs1147169; rs2342558; rs976179; rs1036333; rs976180; rs1976772; rs1541953; rs1837495; rs2053394; rs2117339; rs1440087; rs7420608; rs6434955; rs2165237; rs6434949; rs7582715; rs7587251; rs7590828; rs1992313; rs11889006; rs1440091; rs13382697; rs7581202; rs10190226; rs7600269; rs6726506; rs2196171; rs1401096; rs7592556; rs1371664; rs6434953; rs10497809; rs1368989; rs7572733; rs10184395; rs2196176; rs6716898; rs1016883; rs6434954; rs1025549; rs4410288; rs1518369; rs10196612; rs1304164; rs1607376; rs6715070; rs10184227; rs6738825; rs1866665; rs7573001; rs892514; rs6752454; rs6434950; rs893808; rs11901757; rs10497810; rs7571545; rs6434951; rs7563170; rs10177758; rs882954; rs1850631; rs2164070; rs12693829; rs1371663; rs2139049; rs1961425; rs16826873; rs1401097; rs10204166; rs13394871; rs6745726; rs7602602; rs1518359; rs1595825; rs13408411; rs2119168; rs11683222; rs10931796; rs10497813; rs1579695; rs16827521; rs1850633; rs11890137; rs6434948; rs12105927; rs11891555; rs892513; rs10207232; rs1583792; rs11903129; rs7568948; rs1371665; rs2139050; rs7587598; rs2164071; rs6752458; rs2342557; rs7587043; rs1356542; rs7571869; rs1595823; rs6736825; rs10169453; rs11679484; rs7576221; rs4850818; rs1595824; rs2196172; rs1440089; rs17790682; rs2342556; rs16827267; rs16826320; rs6741701; rs7573687; rs2196175; rs6748683; rs16826791; rs6752760; rs11681663; rs16826895; rs16827456; rs16826872; rs10497811; rs1978888; rs6732517; rs4595967; rs7349300; rs13397178; rs10931798; rs736367; rs16827465; rs1440088; rs11889326; rs10195621; rs10191173; rs10206714; rs17520121; rs12465450; rs11690149; rs10497812; rs10166845; rs1440086; rs11689393; rs1836234; rs5007118; rs10175510; rs2342555; rs11895260; rs4549082; rs6724526; rs11676006; rs35730302; rs17791296; rs892512; rs12623270; rs7579905; rs1518368; rs4417706; rs11690205; rs2164068; rs9712275; rs16826740; rs9973400; rs2196174; rs10931797; rs1371657; rs2009631; rs1036334; rs1808850; rs892515; rs2880366; rs989056; rs1036336; rs1371661; rs3771359; rs10180112; rs3771365; rs6758876; rs3771361; rs1821430; rs6434956; rs2164069; rs3755333; rs11681576; rs1440084; rs3755330; rs13420295; rs7570678; rs1946645; rs7571896; rs4850820; rs2033570; rs10200317; rs11884188; rs10931800; rs1304358; rs6755925; rs3732231; rs10200463; rs3771370; rs3771368; rs1978890; rs4850819; rs7595412; rs3771362; rs16827896; rs11895223; rs10168722; rs6752980; rs11674075; rs3771367; rs16827851; rs12476465; rs11904843; rs16827918; rs10497814; rs1036335; rs12613073; rs12693831; rs10497815; rs986534; rs11884454; rs988583; rs1371659; rs13397026; rs3755332; rs12473467; rs17792650; rs4850821; rs7607044; rs13426297; rs12614662; rs2033569; rs11883868; rs16827593; rs16827819; rs13416439; rs16827923; rs12472100; rs10168721; rs13392163; rs16827729; rs7603309; rs16827916; rs1371660; rs12618469; rs16827788; rs4850822; rs3771369; rs12612977; rs17672607; rs13429722; rs16827921; rs10173738; rs3213867; rs3732232; rs16827694; rs1371658; rs11684176; rs1464209; rs1518360; rs1464210; rs6741084; rs34548437; rs4850441; rs35514871; rs34914408; rs34834250; rs35360200; rs1304165; rs34838834; rs7562132; rs11423327; rs35710464; rs1169458; rs34319496; rs12998989; rs36064148; rs35925285; rs11465077; rs9753097; rs10689149; rs13000637; rs34942811; rs35492290; rs5837576; rs2119169; rs34997942; rs34892290; rs35503807; rs34953848; rs34913887; rs10646938; rs35293068; rs13401268; rs1147168; rs35428842; rs11399169; rs34335129; rs13000419; rs1829358; rs1850634; rs34992068; rs35337305; rs13022936; rs4325749; rs34157959; rs11300427; rs35563720; rs6707815; rs13408177; rs34867071; rs4555344; rs3068250; rs5837578; rs35507350; rs3068222; rs34229236; rs36116085; rs13388318; rs34825619; rs13030657; rs34072014; rs16827438; rs35828708; rs13024144; rs12621502; rs10206257; rs35989106; rs11675025; rs34824539; rs34739422; rs35385198; rs35459961; rs6706633; rs35811589; rs34464991; rs36071237; rs10221706; rs34848522; rs11450711; rs34198712; rs34158633; rs13030838; rs34237103; rs13000620; rs6732340; rs7424606; rs34240767; rs4278926; rs35062652; rs10189006; rs34692727; rs6756641; rs16827329; rs2176544; rs5837579; rs962210; rs35829267; rs28482067; rs10667979; rs13004559; rs17671147; rs34246898; rs10560234; rs1713577; rs11288289; rs34031345; rs35421632; rs34388051; rs28513170; rs35801426; rs10202569; rs13393153; rs34014508; rs34706360; rs34491506; rs34068355; rs34987767; rs4533466; rs35008316; rs1147167; rs7424557; rs35718463; rs4608507; rs35657897; rs34941542; rs35445183; rs35928454; rs5837575; rs7558450; rs13000628; rs13023829; rs13004536; rs11299150; rs34645327; rs34834215; rs7426250; rs1655551; rs35338467; rs35242855; rs13024135; rs35320812; rs10460395; rs955946; rs35119264; rs7567065; rs35333689; rs5837580; rs7585709; rs1850632; rs10552265; rs35071499; rs34584459; rs13387909; rs34894143; rs35035575; rs35429199; rs1630802; rs7559096; rs1978889; rs11423326; rs35638208; rs10708293; rs35226018; rs5837577; rs1878731; rs13394317; rs7424623; rs13000646; rs35852164; rs6732890; rs35291437; rs13402162; rs12329164; rs13014089; rs35988912; rs10175996; rs35207799; rs13000632; rs34809958; rs7582419; rs12999367; rs35151065; rs35334258; rs6722831; rs7608078; rs995925; rs34560060; rs35240938; rs41471147; rs41270239; rs10586893; rs16827882; rs3066169; rs34500216; rs7599640; rs2859806; rs7564543; rs35294687; rs11899729; rs3836135; rs17672571; rs3841904; rs13408403; rs10180081; rs1434287; rs34102559; rs3771366; rs35268804; rs34344108; rs34866078; rs10556429; rs34226193; rs34911573; rs34171660; rs11272623; rs989055; rs35362582; rs35725774; rs1440085; rs34046717; rs6730643; rs13001951; rs2196173; rs13030009; rs35609455; rs13003306; rs41468149; rs10200278; rs1371662; rs35508591; rs35772757; rs35378638; rs5837581; rs35954045; rs35894231; rs12386136; rs5837583; rs35357926; rs6747060; rs13431790; rs3755331; rs16827822; rs10931799; rs34268063; rs35495812; rs3836134; rs12467181; rs35978517; rs7606075; rs7588399; rs35276939; rs28685259; rs12619399; rs13003522; rs6711776; rs34384419; rs11393208; rs10180395; rs13416760; rs4850442; rs2859982; rs13003292; rs35626074; rs3821245; rs10556428; rs35502355; rs3771360; rs6706528; rs13391892; rs34566439; rs11357860; rs1304359; rs13430380; rs35132481; rs34119275; rs5837582; rs7557783; rs13385675; rs7572854; rs10680188; rs34754910; rs35012933; rs10189897; rs10207433; rs11887138; rs11899950; rs12612986; rs1401090; rs1440083; rs1518361; rs1518362; rs1518363; rs1518364; rs1518365; rs1518366; rs1518367; rs1878732; rs1914690; rs4850823; rs938928

# Macromolecular_Interacting_Partner_4_General_References:
7633416

# Macromolecular_Interacting_Partner_4_References:
2116482; 2498914; 8499247; 9645699

End of HMDB00086

Beginning of HMDB00087
# Accession_No:
HMDB00087

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-08 12:06:03

# biospider_lastupdate:
2007-07-24 15:33:26

# Common_Name:
Dimethylamine

# Description:
Dimethylamine (DMA) is an organic secondary amine. It is a colorless, liquefied and flammable gas with an ammonia and fish- like odor.  Dimethylamine is used as dehairing agent in tanning, in dyes, in rubber accelerators, in soaps and cleaning compounds and as an agricultural fungicide.  In the body, DMA also undergoes nitrosation under weak acid conditions to give dimethlynitrosamine. 

# Synonyms:
Dimethylamine; Dimethylamine anhydrous; N,N-Dimethylamine; N-Methylmethanamine; N-methyl-Methanamine; Dimethylamine solution; Dimethylamine anhydrous (dot); Dimethylamine hydrobromide; Dimethylamine aqueous solution; N-methylmethanamine (ACD/Name 4.0)

# Chemical_IUPAC_Name:
N-methylmethanamine

# Chemical_Formula:
C2H7N

# Chemical_Structure:
tbl_chemical:::HMDB00087_ZOOM.png:::119283182712351268

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00087_THUMB.png:::119283182574816727

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Aliphatic Amines; Aromatic Amines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
secondary amine; secondary aliphatic amine (dialkylamine)

# Taxonomy_Biofunction:
Osmolyte

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
45.05785

# Molecular_Weight_Avg:
45.08368

# Smiles_String_isomeric:
CNC

# Smiles_String_canonical:
CNC

# KEGG_Compound_ID:
C00543

# BioCyc_ID:
DIMETHYLAMINE

# PubChem_CID:
674

# PubChem_SID:
3824; 10506039; 10336574; 8150738; 74288; 24864412; 173349; 24864290; 818779; 589719; 24902191; 556141; 15218587; 3885700; 24857770; 4946433; 7887098; 24864274; 24864215; 24866705; 2659; 3135678; 8143667; 11455156

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Dimethylamine

# METLIN_ID:
3758

# Ref_ID:
12097436; 2723829; 7285009; 11197083; 12716783; 12072675; 9869358; 12203047; 8257730; 9665433; 7762816; 1779307; 7758205; 12065217; 12019127

# ChEBI_ID:
17170

# CAS_Registry_Number:
124-40-3

# InChI:
InChI=1/C2H7N/c1-3-2/h3H,1-2H3

# Synthesis_Reference:
The chemistry of the alkali amides. II.     Bergstrom, F. W.; Fernelius, W. Conard.    Chem. Rev.  (1937),  20  413-81.

# Melting_Point:
-92.2 oC

# Melting_Point_predicted:
16.3 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1630 mg/mL at 40 oC [SCHWEIZER,AE et al. (1978)]

# H2O_Solubility_Predicted:
516.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Liquid

# LogP:
-0.38 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-0.53 [Predicted by ALOGPS]; -0.2 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::dimethylamine.pdf:::1132562198516915428

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Dimethylamine.mol:::1132723806375640352

# SDF_File_[Text]:
tbl_chemical:::HMDB00087.sdf:::119283182301252191

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00087.pdb:::119283182439142818

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::dimethylamine.FID:::114246614685773159

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::dimethylamine.png:::114246614689916271

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::041103_P00_02_HW_1DC_47.jpg:::114168459522043373

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041103_P00_02_HW_1DC_47.zip:::114168459518078341

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041103_P00_02_HW_1DC_47_Assigned.jpg:::114322915879834145

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041103_P00_02_HW_2DHSQC_144.jpg:::11449568817278247

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041103_P00_02_HW_2DHSQC_144.zip:::11449568818423167

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041103_P00_02_HW_2DHSQC_144_Assigned.jpg:::11449568820233204

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Dimethylamine.gif:::1132732107000516594

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00087_peaks.txt:::115630953690210671

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Dimethylamine_C.gif:::1132737679439863578

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00087_peaks.txt:::1156310727200622101

# Mass_Spectrum:
tbl_chemical:::HMDB00087.jpg:::1132798876609221243

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Fibroblasts; Neurons

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Urine	25.2 +/- 1.2	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9665433
Blood	>10	umol/L	Adult:>18_yrs_old	Both	Normal	7762816
Cerebrospinal_Fluid(CSF)	7.0 +/- 4.0	uM	Adult:>18_yrs_old	Both	Normal	HMP Experimental
Saliva	136 (9.00-262)	umol/L	Adult:>18_yrs_old	Both	Normal	12097436


# Concentration_[Abnormal]:
Urine	25.4 (8.22-42.7)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Diabetic Ketosis	7758205


# Associated_Disorders:
Diabetic Ketosis; Hypogammaglobulinaemia; Pernicious Anemia; Uremia

# Pathway_Names:
Methane metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00680

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
6044

# Metabolic_Enzyme_1_Name:
NG,NG-dimethylarginine dimethylaminohydrolase 1

# Metabolic_Enzyme_1_Synonyms:
Dimethylargininase-1; Dimethylarginine dimethylaminohydrolase 1; DDAHI; DDAH-1

# Metabolic_Enzyme_1_Gene_Name:
DDAH1

# Metabolic_Enzyme_1_Protein_Sequence:
>NG,NGdimethylarginine dimethylaminohydrolase 1
MAGLGHPAAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGL
QVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMK
DENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSM
AGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDIAANCIYLNIPNKGHVLLHRTPE
EYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTCCSVLINKKVDS

# Metabolic_Enzyme_1_Number_of_Residues:
285

# Metabolic_Enzyme_1_Molecular_Weight:
31122

# Metabolic_Enzyme_1_Theoretical_pI:
5.61

# Metabolic_Enzyme_1_GO_Classification:
Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in nitric oxide generation

# Metabolic_Enzyme_1_Pathway:
Not Available

# Metabolic_Enzyme_1_Reaction:
N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF02274:Amidinotransf

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.5.3.18

# Metabolic_Enzyme_1_GenBank_ID_Protein:
4160666

# Metabolic_Enzyme_1_SwissProt_ID:
DDAH1_HUMAN (O94760)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
DDAH1

# Metabolic_Enzyme_1_Geneatlas_id:
DDAH1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2715

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>858 bp
ATGGCCGGGCTCGGCCACCCCGCCGCCTTCGGCCGGGCCACCCACGCCGTGGTGCGGGCG
CTACCCGAGTCGCTCGGCCAGCACGCGCTGAGAAGCGCCAAGGGCGAGGAGGTGGACGTC
GCCCGCGCGGAACGGCAGCACCAGCTCTACGTGGGCGTGCTGGGCAGCAAGCTGGGGCTG
CAGGTGGTGGAGCTGCCGGCCGACGAGAGCCTTCCGGACTGCGTCTTCGTGGAGGACGTG
GCCGTGGTGTGCGAGGAGACGGCCCTCATCACCCGACCCGGGGCGCCGAGCCGGAGGAAG
GAGGTTGACATGATGAAAGAAGCATTAGAAAAACTTCAGCTCAATATAGTAGAGATGAAA
GATGAAAATGCAACTTTAGATGGCGGAGATGTTTTATTCACAGGCAGAGAATTTTTTGTG
GGCCTTTCCAAAAGGACAAATCAACGAGGTGCTGAAATCTTGGCTGATACTTTTAAGGAC
TATGCAGTCTCCACAGTGCCAGTGGCAGATGGGTTGCATTTGAAGAGTTTCTGCAGCATG
GCTGGGCCTAACCTGATCGCAATTGGGTCTAGTGAATCTGCACAGAAGGCCCTTAAGATC
ATGCAACAGATGAGTGACCACCGCTACGACAAACTCACTGTGCCTGATGACATAGCAGCA
AACTGTATATATCTAAATATCCCCAACAAAGGGCACGTCTTGCTGCACCGAACCCCGGAA
GAGTATCCAGAAAGTGCAAAGGTTTATGAGAAACTGAAGGACCATATGCTGATCCCCGTG
AGCATGTCTGAACTGGAAAAGGTGGATGGGCTGCTCACCTGCTGCTCAGTTTTAATTAAC
AAGAAAGTAGACTCCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AB001915

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_1_Locus:
1p22

# Metabolic_Enzyme_1_SNPs:
rs10158674; rs233113; rs233112; rs233111; rs233114; rs3087894; rs3813603; rs4399206; rs3813600; rs11161597; rs233115; rs11809833; rs12043505; rs1054529; rs1523993; rs669173; rs233119; rs591917; rs233069; rs604974; rs1498373; rs233124; rs233047; rs648216; rs506733; rs2037594; rs233046; rs233125; rs1001604; rs1146384; rs233122; rs877041; rs2300637; rs2012683; rs1523994; rs506082; rs974874; rs1523991; rs233091; rs1146383; rs597168; rs648310; rs1006989; rs233044; rs18582; rs1342323; rs582145; rs659070; rs593728; rs2268667; rs2124139; rs11161614; rs530006; rs1146381; rs6657732; rs997251; rs233084; rs233048; rs7539738; rs1523998; rs7532508; rs1554597; rs1146382; rs1357635; rs4949890; rs233120; rs6673833; rs2300634; rs182845; rs4949900; rs11161615; rs233118; rs990916; rs2076699; rs233072; rs2300633; rs6420965; rs761601; rs10489513; rs233128; rs1241321; rs6576765; rs1391556; rs1975755; rs527762; rs233099; rs1884139; rs2177461; rs233050; rs6671599; rs1498375; rs10873700; rs1006988; rs11161618; rs233080; rs233071; rs233085; rs6657817; rs6576764; rs7555486; rs10782548; rs11161604; rs233051; rs233054; rs6576763; rs233060; rs1498374; rs17388437; rs233075; rs11161617; rs3949301; rs1240939; rs423105; rs12562882; rs12044537; rs12079965; rs12132677; rs233093; rs6672870; rs233043; rs12133722; rs17127565; rs7515261; rs2037593; rs12140457; rs233068; rs12130591; rs17126044; rs2300640; rs2935; rs17388696; rs7521189; rs17384381; rs12140935; rs233090; rs13373844; rs233053; rs2016104; rs12033483; rs11161616; rs3738111; rs12717764; rs6704103; rs233094; rs6576761; rs11161606; rs12402128; rs11582061; rs11161611; rs11801146; rs1357636; rs551140; rs12568675; rs11587876; rs233127; rs12717763; rs553257; rs1523995; rs233131; rs12126355; rs12123745; rs6697083; rs12564550; rs3768226; rs11161607; rs4949902; rs729655; rs17127637; rs10493764; rs986639; rs4428939; rs2011825; rs233130; rs480414; rs2284798; rs10873702; rs173026; rs233045; rs10747318; rs233074; rs2300639; rs233126; rs761602; rs7540393; rs233049; rs233095; rs17388521; rs7555670; rs12743049; rs12130380; rs17590006; rs17127399; rs10873701; rs12129502; rs233097; rs11809053; rs17127623; rs1342324; rs3216613; rs2300638; rs233098; rs233088; rs11805470; rs2207368; rs12029684; rs641864; rs12724823; rs600098; rs233058; rs7526667; rs233066; rs17127172; rs1146374; rs3831832; rs731194; rs11161610; rs12047220; rs233062; rs1241319; rs12128907; rs17388780; rs12564698; rs10489511; rs233070; rs1965876; rs233132; rs233076; rs3768227; rs1146377; rs12140103; rs11806762; rs233096; rs17127199; rs1498377; rs233059; rs12138852; rs233133; rs12130145; rs11802126; rs2892888; rs12024508; rs12410538; rs2474123; rs10782549; rs12123722; rs631817; rs12063342; rs17127710; rs12121675; rs10489512; rs233061; rs233079; rs17126791; rs7552422; rs650929; rs12135333; rs11802673; rs560090; rs17127231; rs485987; rs6576766; rs1241320; rs11588128; rs233121; rs1146378; rs1146386; rs4001163; rs12758237; rs5003501; rs11161608; rs1261681; rs7525786; rs11808537; rs483524; rs5003310; rs17127190; rs12129013; rs2284800; rs17389081; rs12046433; rs3216612; rs11807361; rs17127201; rs3920521; rs11809702; rs11589491; rs570121; rs12022538; rs12136295; rs12034206; rs233087; rs10747319; rs12118950; rs233117; rs233064; rs10782550; rs6658151; rs12033170; rs529582; rs233057; rs17384213; rs560995; rs12143626; rs7554669; rs7547571; rs6576767; rs11806417; rs3851268; rs12029474; rs12043604; rs12049582; rs233063; rs2389948; rs11161609; rs1045609; rs12041140; rs684569; rs233092; rs539714; rs17389112; rs1146379; rs561614; rs2284797; rs485928; rs1554596; rs17387935; rs11799987; rs2840319; rs769288; rs12034249; rs233089; rs1608536; rs2474121; rs12140170; rs233067; rs6685360; rs20862; rs10489509; rs233109; rs10489510; rs35758461; rs11811309; rs11550406; rs12045545; rs34184003; rs9388; rs3841329; rs233116; rs41305858; rs3196; rs2389913; rs2613; rs12034481; rs35145687; rs35444469; rs35479962; rs4391710; rs34793346; rs34648155; rs7520420; rs2389950; rs35725093; rs12140272; rs12090059; rs35952352; rs536997; rs12070066; rs233081; rs34596709; rs34721625; rs12036246; rs4512701; rs12035116; rs2235990; rs34609757; rs12086327; rs35785635; rs34794001; rs12024405; rs2300635; rs12127494; rs35761966; rs35790738; rs35193119; rs11369676; rs7552324; rs34949125; rs5775835; rs35081595; rs2168194; rs35120581; rs34485961; rs35046437; rs12736004; rs4949898; rs4292996; rs34633935; rs12048263; rs33926071; rs12131926; rs34823363; rs11446322; rs34624602; rs7553530; rs12729851; rs4949899; rs12567405; rs35810227; rs233082; rs414484; rs34296620; rs34344219; rs34520534; rs662671; rs35851797; rs28438539; rs28489187; rs7418142; rs34083263; rs35461391; rs12741550; rs34462970; rs11358089; rs12724419; rs34303737; rs3057840; rs34748501; rs3058796; rs11811186; rs10579569; rs34018000; rs12139958; rs11805144; rs2056564; rs12027461; rs4001153; rs6659486; rs34531071; rs233055; rs12071648; rs12568573; rs34688912; rs34757615; rs35030569; rs35183465; rs12727954; rs233073; rs34750524; rs1608537; rs34032001; rs12724149; rs34579273; rs34408053; rs4631749; rs2284799; rs12049529; rs12758768; rs12063854; rs12059670; rs35279662; rs35943827; rs36110608; rs4631750; rs1146380; rs12060720; rs12042485; rs12070067; rs35294786; rs2168195; rs11365834; rs12062903; rs35984248; rs12029619; rs4949903; rs12033473; rs233065; rs35711601; rs12142800; rs3768223; rs12754419; rs2124140; rs3768224; rs12047422; rs35876501; rs10604831; rs12032315; rs28847138; rs12142332; rs12747710; rs958345; rs35415858; rs1563252; rs233056; rs35139188; rs17127750; rs11378265; rs12022443; rs35001077; rs2056563; rs12022248; rs35002949; rs11802530; rs34199952; rs12124072; rs11296270; rs5775842; rs34534147; rs34119750; rs34856510; rs7520678; rs35496019; rs41289749; rs13375684; rs11379166; rs34052982; rs35719067; rs12754297; rs12122816; rs2420312; rs4001155; rs41301261; rs11445983; rs35956189; rs35192705; rs35392469; rs12125900; rs1498376; rs34005548; rs12094973; rs36166679; rs10680800; rs10677714; rs416890; rs35901619; rs2892887; rs35486869; rs5775833; rs36179506; rs34484485; rs12027711; rs34431273; rs233086; rs34912595; rs35822306; rs34073126; rs12567636; rs12034839; rs12047139; rs35479795; rs2389949; rs35755993; rs233052; rs11161619; rs7532994; rs5775841; rs686166; rs13375203; rs34852274; rs35862161; rs5775838; rs11161599; rs35364655; rs34075805; rs12125557; rs4949904; rs35596907; rs11314404; rs12025443; rs35923645; rs5775837; rs11443348; rs36104818; rs12116463; rs12021849; rs34278923; rs12138413; rs28845169; rs12038279; rs41379646; rs34749578; rs6576762; rs233083; rs12131258; rs233077; rs12036146; rs11373035; rs11806483; rs11161612; rs2124138; rs12097394; rs35263511; rs12029221; rs12747634; rs4475804; rs28816748; rs2064510; rs34695795; rs11394406; rs6673791; rs1523992; rs35352719; rs35458500; rs12120551; rs35905077; rs3057846; rs4998996; rs35749451; rs12044239; rs4001164; rs28529751; rs13375679; rs35022397; rs35750802; rs12064909; rs499869; rs10747320; rs10630765; rs12023006; rs34102729; rs17126049; rs12039188; rs35053325; rs34810153; rs950001; rs35817800; rs1832883; rs34243833; rs11809825; rs35025364; rs233123; rs2300636; rs36109764; rs561422; rs35347605; rs12038426; rs12122482; rs233078; rs12122163; rs5775840; rs35104560; rs509361; rs12124044; rs12565015; rs12130178; rs34003063; rs11335286; rs12410825; rs36026418; rs34652073; rs36062892; rs596693; rs7531873; rs35460568; rs4281359; rs233129; rs661686; rs35476464; rs13374410; rs12033315; rs34559149; rs12124170; rs10666315; rs5775836; rs28462335; rs4949905; rs7520993; rs11161613; rs35486621; rs11301537; rs34294347; rs41438644; rs7546931; rs36103030; rs36115358; rs12024354; rs35092233; rs34223283; rs12044882; rs34508710; rs233110; rs604421; rs12735238; rs12138621; rs547265; rs10675813; rs12023795; rs12119083; rs28653313; rs10157511; rs10157640; rs10157643; rs10158333; rs10782551; rs10873699; rs10873703; rs11161595; rs11161596; rs11590830; rs12047189; rs12082194; rs12122154; rs12134668; rs13374965; rs1403951; rs1403954; rs1403955; rs1403956; rs1874807; rs233103; rs233104; rs233108; rs4415623; rs4949906; rs535723; rs536509; rs587843; rs588672; rs7538364; rs975880

# Metabolic_Enzyme_1_General_References:
9874257; 10493931

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6045

# Metabolic_Enzyme_2_Name:
NG,NG-dimethylarginine dimethylaminohydrolase 2

# Metabolic_Enzyme_2_Synonyms:
Dimethylargininase-2; Dimethylarginine dimethylaminohydrolase 2; DDAHII; DDAH-2; S-phase protein; Protein G6a

# Metabolic_Enzyme_2_Gene_Name:
DDAH2

# Metabolic_Enzyme_2_Protein_Sequence:
>NG,NGdimethylarginine dimethylaminohydrolase 2
MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQL
LELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEIGDE
NATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGPSHLRGLCGMGG
PRTVVAGSSDAAQKAVRAMAVLTDHPYASLTLPDDAAADCLFLRPGLPGVPPFLLHRGGG
DLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHS

# Metabolic_Enzyme_2_Number_of_Residues:
285

# Metabolic_Enzyme_2_Molecular_Weight:
29644

# Metabolic_Enzyme_2_Theoretical_pI:
5.90

# Metabolic_Enzyme_2_GO_Classification:
Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in nitric oxide generation

# Metabolic_Enzyme_2_Pathway:
Not Available

# Metabolic_Enzyme_2_Reaction:
N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF02274:Amidinotransf

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.5.3.18

# Metabolic_Enzyme_2_GenBank_ID_Protein:
4454710

# Metabolic_Enzyme_2_SwissProt_ID:
DDAH2_HUMAN (O95865)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
DDAH2

# Metabolic_Enzyme_2_Geneatlas_id:
DDAH2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:2716

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>858 bp
ATGGGGACGCCGGGGGAGGGGCTGGGCCGCTGCTCCCATGCCCTGATCCGGGGAGTCCCA
GAGAGCCTGGCGTCGGGGGAAGGTGCGGGGGCTGGCCTTCCCGCTCTGGATCTGGCCAAA
GCTCAAAGGGAGCACGGGGTGCTGGGAGGTAAACTGAGGCAACGACTGGGGCTACAGCTG
CTAGAACTGCCACCTGAGGAGTCATTGCCGCTGGGACCGCTGCTTGGCGACACGGCCGTG
ATCCAAGGGGACACGGCCCTAATCACGCGGCCCTGGAGCCCCGCTCGTAGGCCAGAGGTC
GATGGAGTCCGCAAAGCCCTGCAAGACCTGGGGCTCCGAATTGTGGAAATAGGAGACGAG
AACGCGACGCTGGATGGCACTGACGTTCTCTTCACCGGCCGGGAGTTTTTCGTAGGCCTC
TCCAAATGGACCAATCACCGAGGAGCTGAGATCGTGGCGGACACGTTCCGGGACTTCGCC
GTCTCCACTGTGCCAGTCTCGGGTCCCTCCCACCTGCGCGGTCTCTGCGGCATGGGGGGA
CCTCGCACTGTTGTGGCAGGCAGCAGCGACGCTGCCCAAAAGGCTGTCCGGGCAATGGCA
GTGCTGACAGATCACCCATATGCCTCCCTGACCCTCCCAGATGACGCAGCTGCTGACTGC
CTCTTTCTTCGTCCTGGGTTGCCTGGTGTGCCCCCTTTCCTCCTGCACCGTGGAGGTGGG
GATCTGCCCAACAGCCAGGAGGCACTGCAGAAGCTCTCTGATGTCACCCTGGTACCTGTG
TCCTGCTCAGAACTGGAGAAGGCTGGCGCCGGGCTCAGCTCCCTCTGCTTGGTGCTCAGC
ACACGCCCCCACAGCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF070667

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_2_Locus:
6p21.3

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
10493931; 10384126; 14574404

# Metabolic_Enzyme_2_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7735

# Macromolecular_Interacting_Partner_1_Name:
Methyl-CpG-binding domain protein 2

# Macromolecular_Interacting_Partner_1_Synonyms:
Methyl-CpG-binding protein MBD2; Demethylase; DMTase

# Macromolecular_Interacting_Partner_1_Gene_Name:
MBD2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>MethylCpGbinding domain protein 2
MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRG
RGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGG
APRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYF
SPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLN
TTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQII
KTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCK
AFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
411

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
43255

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
10.76

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemi-methylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Isoform 1 may enhance the activation of some unmethylated cAMP-responsive promoters. Reports about DNA demethylase activity of isoform 2 are contradictory

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01429:MBD

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
3800793

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
MBD2_HUMAN (Q9UBB5)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
MBD2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
MBD2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6917

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Nucleus. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1236 bp
ATGCGCGCGCACCCGGGGGGAGGCCGCTGCTGCCCGGAGCAGGAGGAGGGGGAGAGTGCG
GCGGGCGGCAGCGGCGCTGGCGGCGACTCCGCCATAGAGCAGGGGGGCCAGGGCAGCGCG
CTCGCCCCGTCCCCGGTGAGCGGCGTGCGCAGGGAAGGCGCTCGGGGCGGCGGCCGTGGC
CGGGGGCGGTGGAAGCAGGCGGGCCGGGGCGGCGGCGTCTGTGGCCGTGGCCGGGGCCGG
GGCCGTGGCCGGGGACGGGGACGGGGCCGGGGCCGGGGCCGCGGCCGTCCCCCGAGTGGC
GGCAGCGGCCTTGGCGGCGACGGCGGCGGCTGCGGCGGCGGCGGCAGCGGTGGCGGCGGC
GCCCCCCGGCGGGAGCCGGTCCCTTTCCCGTCGGGGAGCGCGGGGCCGGGGCCCAGGGGA
CCCCGGGCCACGGAGAGCGGGAAGAGGATGGATTGCCCGGCCCTCCCCCCCGGATGGAAG
AAGGAGGAAGTGATCCGAAAATCTGGGCTAAGTGCTGGCAAGAGCGATGTCTACTACTTC
AGTCCAAGTGGTAAGAAGTTCAGAAGCAAGCCTCAGTTGGCAAGGTACCTGGGAAATACT
GTTGATCTCAGCAGTTTTGACTTCAGAACTGGAAAGATGATGCCTAGTAAATTACAGAAG
AACAAACAGAGACTGCGAAACGATCCTCTCAATCAAAATAAGGGTAAACCAGACTTGAAT
ACAACATTGCCAATTAGACAAACAGCATCAATTTTCAAACAACCGGTAACCAAAGTCACA
AATCATCCTAGTAATAAAGTGAAATCAGACCCACAACGAATGAATGAACAGCCACGTCAG
CTTTTCTGGGAGAAGAGGCTACAAGGACTTAGTGCATCAGATGTAACAGAACAAATTATA
AAAACCATGGAACTACCCAAAGGTCTTCAAGGAGTTGGTCCAGGTAGCAATGATGAGACC
CTTTTATCTGCTGTTGCCAGTGCTTTGCACACAAGCTCTGCGCCAATCACAGGGCAAGTC
TCCGCTGCTGTGGAAAAGAACCCTGCTGTTTGGCTTAACACATCTCAACCCCTCTGCAAA
GCTTTTATTGTCACAGATGAAGACATCAGGAAACAGGAAGAGCGAGTACAGCAAGTACGC
AAGAAATTGGAAGAAGCACTGATGGCAGACATCTTGTCGCGAGCTGCTGATACAGAAGAG
ATGGATATTGAAATGGACAGTGGAGATGAAGCCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AF072242

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:18

# Macromolecular_Interacting_Partner_1_Locus:
18q21

# Macromolecular_Interacting_Partner_1_SNPs:
rs1259938; rs1259941; rs7614; rs3786254; rs4041245; rs1730267; rs11877833; rs3786255; rs35733000; rs4987184; rs1259940; rs11663319; rs1259939; rs1145308; rs661215; rs676800; rs1145316; rs543241; rs2926997; rs585835; rs584330; rs475368; rs2926341; rs8083077; rs4940316; rs687994; rs599482; rs8090480; rs573285; rs672947; rs1145315; rs8094493; rs1145309; rs4041246; rs140691; rs609791; rs1790514; rs492726; rs693857; rs1145317; rs685057; rs8086950; rs662336; rs572797; rs10502986; rs1145310; rs7234495; rs4939750; rs8094185; rs479852; rs9958418; rs7232422; rs7241063; rs9960390; rs1145311; rs570017; rs570867; rs12957175; rs615696; rs1145312; rs16957946; rs8089935; rs7237892; rs10502987; rs3017292; rs1730270; rs4940315; rs16957921; rs1267799; rs4939751; rs9963926; rs498705; rs656923; rs8097780; rs583268; rs4987185; rs629824; rs17554142; rs16957953; rs7238796; rs4940312; rs629473; rs17462973; rs4987186; rs671835; rs656306; rs642361; rs35040517; rs16957939; rs9951912; rs11873149; rs9807692; rs1259858; rs17462765; rs17462646; rs16957932; rs603097; rs12608387; rs35915489; rs9963869; rs753864; rs7241067; rs1268764; rs11875248; rs1145307; rs11345394; rs11344752; rs9946304; rs34174132; rs11364876; rs28404719; rs9956656; rs11552898; rs1790513; rs10558467; rs3017295; rs3017287; rs623876; rs634693; rs9961259; rs642383; rs34993600; rs1145313; rs678114; rs8093652; rs7229672; rs34025949; rs16957923; rs8092125; rs1730279; rs35601988; rs35170749; rs16957906; rs35186700; rs1730271; rs1790515; rs12326535; rs34382203; rs1675718; rs35225687; rs509794; rs34458441; rs5825061; rs28448589; rs3018200; rs11874884; rs645506; rs35237708; rs34234339; rs34545409; rs36037876; rs36079641; rs626357; rs34556367; rs2169361; rs16957902; rs8094268; rs36230166; rs510530; rs34887478; rs3017286; rs12963699; rs11277762; rs35790077; rs10607975; rs35199872; rs12232598; rs543989; rs16957887; rs594296; rs611912; rs2926999; rs2199388; rs11300205; rs7235939; rs2926343; rs645961; rs7233296; rs16957881; rs11293678; rs35824179; rs35056647; rs2956143; rs554633; rs681289; rs2926342; rs10719481; rs3017296; rs11285730; rs35643173; rs34165824; rs8095425; rs35571665; rs16957892; rs34076609; rs10607976; rs1812558; rs1674711; rs35362298; rs7239431; rs34992594; rs28433825; rs7240184; rs36115254; rs35922006; rs3017288; rs34003182; rs1145314; rs1730269; rs17463119; rs586244; rs34014406; rs35697526; rs10666436; rs2614359; rs668141; rs34283776; rs35667017; rs3018197; rs12963932; rs34366283; rs3017294; rs613506; rs11295866; rs684456; rs34113185; rs2446537; rs1272783; rs681942; rs12326943; rs34411987; rs34574073; rs1145319; rs11271806; rs2219626; rs35551191; rs586302; rs28637773; rs36211882; rs7241787; rs2610528; rs2610529; rs568092; rs2056778; rs35696367; rs473734; rs4939752; rs34716232; rs9748585; rs11665560; rs5825062; rs12608372; rs3017298; rs28448407; rs4940317; rs35153750; rs11875214; rs1259842; rs1259936; rs1259937; rs12607263; rs1273266; rs1471216; rs16957870; rs636450; rs649780; rs649896; rs8084184; rs8086877; rs8089348; rs9807513

# Macromolecular_Interacting_Partner_1_General_References:
9774669; 10441743; 10947852; 11102443; 12183469

# Macromolecular_Interacting_Partner_1_References:
597609; 6719461

End of HMDB00087

Beginning of HMDB00089
# Accession_No:
HMDB00089

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-09-27 13:27:57

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Cytidine

# Description:
A pyrimidine nucleoside that is composed of the base CYTOSINE linked to the five-carbon sugar D-RIBOSE.
Cytidine is formed when cytosine is attached to a ribose ring (also known as a ribofuranose) via a &#946;-N1-glycosidic bond. (Wikipedia)

# Synonyms:
1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine; 1-b-D-Ribofuranosylcytosine; 1-b-D-ribosyl-Cytosine; 1-beta-D-Ribofuranosylcytosine; 1-beta-D-ribofuranosyl-Cytosine; 1beta-D-Ribofuranosylcytosine; 1beta-Ribofuranosylcytosine; 4-Amino-1-b-D-ribofuranosyl-2(1H)-pyrimidinone; Cytidine; Cytosine riboside; cytosine-1b-D-Ribofuranoside; cytosine-1beta-D-Ribofuranoside; 1-(b-delta-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine; 1-beta-delta-Ribofuranosylcytosine; 1-beta-delta-ribosyl-Cytosine; 1-beta-delta-ribofuranosyl-Cytosine; 1beta-delta-Ribofuranosylcytosine; 4-Amino-1-beta-delta-ribofuranosyl-2(1H)-pyrimidinone; cytosine-1b-delta-Ribofuranoside; cytosine-1beta-delta-Ribofuranoside

# Chemical_IUPAC_Name:
4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-pyrimidin-2-one

# Chemical_Formula:
C9H13N3O5

# Chemical_Structure:
tbl_chemical:::HMDB00089_ZOOM.png:::119283183741946939

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00089_THUMB.png:::119283183542414850

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines; Nucleosides

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; primary alcohol; secondary alcohol; 1,2-diol; primary amine; primary aromatic amine; oxo(het)arene; urea; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Protein component; Component of Pyrimidine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
243.08553

# Molecular_Weight_Avg:
243.21661

# Smiles_String_isomeric:
NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O

# Smiles_String_canonical:
NC1=NC(=O)N(C=C1)C2OC(CO)C(O)C2O

# KEGG_Compound_ID:
C00475

# BioCyc_ID:
CYTIDINE

# PubChem_CID:
6175

# PubChem_SID:
3132638; 833276; 3758; 841097; 12109173; 8144101; 11110524; 149078; 8153876; 610624

# OMIM_ID:
269921; 603209

# Metagene_ID:
Not Available

# BiGG_ID:
35089

# Wikipedia_ID:
Cytidine

# METLIN_ID:
3376

# Ref_ID:
15116424; 16099907; 6656991; 16103149; 16102577; 16150200; 16091246

# ChEBI_ID:
17562

# CAS_Registry_Number:
65-46-3

# InChI:
InChI=1/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1

# Synthesis_Reference:
Dephosphorylation of ribonucleoside 2'(3')-phosphates.     Zemlicka, Jiri; Chladek, Stanislav.    Ceskoslov. Akad. Ved,  Prague,  Czech.    Tetrahedron Letters  (1969),   (9),  715-18.

# Melting_Point:
230.5 oC

# Melting_Point_predicted:
114.9 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
176.0 mg/mL [MEYLAN,WM et al. (1996)]; 44.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-2.51 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-2.17 [Predicted by ALOGPS]; -2.8 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Cytidine.mol:::1132723806546148162

# SDF_File_[Text]:
tbl_chemical:::HMDB00089.sdf:::119283183104291491

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00089.pdb:::119283183402690604

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::050126_P00_03_IS_1DP_presat_expanded_2.gif:::114460741792735853

# H_NMR_FIDS_Spectra_Wishart:


# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::cytidine.png:::114410367194153279

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050126_P00_03_IS_2DHSQC_534.jpg:::114617701502076309

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050126_P00_03_IS_2DHSQC_534.zip:::114617701502912895

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050126_P00_03_IS_2DHSQC_534_Assigned.jpg:::114781511121377776

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Cytidine.gif:::1132732107218844180

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00089_peaks.txt:::1156309537927694404

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Cytidine_C.gif:::1132737680040724895

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00089_peaks.txt:::1156310728232364342

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00089L.png:::117555262093272219; Medium Energy:tbl_ms:::HMDB00089M.png:::117555267182142419; High Energy:tbl_ms:::HMDB00089H.png:::117555271046123950

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000190.png:::116907444590683544

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000190.txt:::116907444590682602

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000190.png:::116890830684366422

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000190.txt:::116890830707837144

# Cellular_Location:
Cytoplasm (Predicted from LogP); Extracellular; lysosome; mitochondria; nucleus

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	0.78 (0.00-1.6)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	15116424
Blood	0.1	umol/L	Adult:>18_yrs_old	Both	Normal	6656991
Blood	<0.1	uM	Adult:>18_yrs_old	Both	Normal	6656991


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Degenerative disc disease; Ovarian Carcinoma; Promyelocytic Leukemia; Stroke

# Pathway_Names:
Purine metabolism;Nicotinate and nicotinamide metabolism

# Pathway_Images:
Purine_Synthesis.jpg;Nicotinamide_synthesis_(NADH).jpg

# KEGG_Images:
map00230;map00760

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;Nicotinamide_synthesis_(NADH)_Graph.jpg

# Pathway_SBMLs:
Purine_Synthesis.xml;Nicotinamide_synthesis_(NADH).xml

# Metabolic_Enzyme_1_ID:
5236

# Metabolic_Enzyme_1_Name:
5'(3')-deoxyribonucleotidase, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
5',3'-nucleotidase, mitochondrial; Deoxy-5'-nucleotidase 2; dNT-2

# Metabolic_Enzyme_1_Gene_Name:
NT5M

# Metabolic_Enzyme_1_Protein_Sequence:
>5'3'deoxyribonucleotidase, mitochondrial precursor
MIRLGGWCARRLCSAAVPAGRRGAAGGLGLAGGRALRVLVDMDGVLADFEGGFLRKFRAR
FPDQPFIALEDRRGFWVSEQYGRLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMAS
LQNTDVFICTSPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDI
TGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRPC

# Metabolic_Enzyme_1_Number_of_Residues:
228

# Metabolic_Enzyme_1_Molecular_Weight:
25862

# Metabolic_Enzyme_1_Theoretical_pI:
8.12

# Metabolic_Enzyme_1_GO_Classification:
Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP

# Metabolic_Enzyme_1_Pathway:
Not Available

# Metabolic_Enzyme_1_Reaction:
Not Available

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_1_Signals:
1-15

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
9408106

# Metabolic_Enzyme_1_SwissProt_ID:
NT5M_HUMAN (Q9NPB1)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
NT5M

# Metabolic_Enzyme_1_Geneatlas_id:
NT5M

# Metabolic_Enzyme_1_hgnc_id:
HGNC:15769

# Metabolic_Enzyme_1_PDB_ID:
1Q92

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_1_Gene_Sequence:
>687 bp
ATGATCCGGCTGGGCGGCTGGTGTGCGCGGCGGCTCTGCAGCGCGGCGGTTCCCGCGGGG
CGGCGCGGGGCGGCGGGCGGGCTGGGCCTGGCGGGAGGCCGCGCCCTACGGGTGCTGGTG
GACATGGACGGCGTGCTGGCTGACTTCGAGGGCGGATTCCTCAGGAAGTTCCGCGCGCGC
TTTCCCGACCAGCCCTTCATCGCGCTGGAGGACCGGCGCGGCTTCTGGGTGTCGGAGCAG
TACGGCCGCCTGCGGCCAGGGCTGAGCGAGAAGGCCATCAGCATTTGGGAGTCAAAGAAT
TTCTTTTTTGAACTTGAGCCTCTGCCAGGGGCCGTGGAAGCTGTCAAGGAGATGGCCAGC
CTACAAAACACTGACGTCTTCATCTGCACAAGCCCCATCAAGATGTTCAAGTACTGTCCC
TATGAGAAGTATGCCTGGGTGGAGAAGTACTTTGGCCCTGACTTTCTGGAGCAGATTGTG
CTGACCAGAGACAAGACCGTGGTCTCTGCTGACCTTCTCATAGACGACCGGCCGGACATC
ACAGGGGCCGAGCCAACCCCCAGCTGGGAGCATGTCCTCTTCACCGCCTGCCACAACCAG
CACCTGCAGCTGCAGCCCCCCCGCCGCAGGCTGCACTCGTGGGCGGACGACTGGAAGGCC
ATTCTGGACAGCAAGCGGCCCTGCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AJ277557

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_1_Locus:
17p11.2

# Metabolic_Enzyme_1_SNPs:
rs2240876; rs758742; rs1860553; rs242243; rs6502579; rs7223473; rs11078384; rs7226068; rs10468464; rs12948296; rs1860552; rs9912109; rs9898622; rs7211968; rs17726703; rs9914692; rs3785502; rs11867932; rs3785504; rs17726673; rs11654778; rs16942153; rs17726858; rs11078382; rs3826302; rs2064060; rs6502580; rs7217503; rs9912172; rs3785506; rs9908168; rs11652902; rs9902505; rs4985707; rs6502576; rs6502578; rs16961564; rs7210344; rs16961516; rs242242; rs171394; rs12600778; rs9909111; rs7219752; rs6502577; rs12601631; rs11869054; rs17726924; rs9891799; rs11870836; rs11869507; rs11078383; rs4985706; rs7217162; rs9889738; rs9908338; rs7222555; rs9915883; rs7211243; rs9916133; rs9907857; rs9905836; rs11657817; rs9889298; rs7220829; rs9903425; rs9908360; rs9914424; rs9908124; rs11650700; rs11869079; rs7212369; rs9889367; rs7217114; rs9896977; rs9916676; rs16961561; rs12602026; rs9896970; rs9904396; rs9909850; rs10852849; rs11078385; rs6502575; rs242244; rs16961576; rs3203918; rs8082383; rs7212012; rs36114962; rs9889834; rs7226045; rs12602003; rs9894669; rs35712658; rs12941075; rs7210625; rs35320589; rs11655849; rs35470335; rs34668117; rs12943271; rs34446504; rs35945070; rs34219219; rs12951176; rs35554631; rs34408375; rs28825184; rs7218566; rs35917484; rs28880443; rs9904393; rs12601106; rs34579357; rs4985765; rs9907711; rs11343472; rs35579933; rs3087093; rs12951985; rs34993127; rs36088408; rs36091965; rs34100977; rs7220057; rs8080335; rs9901325; rs35720826; rs34886391; rs12949216; rs9898993; rs34121330; rs34513135; rs12936127; rs8067236; rs8081939; rs10617184; rs7211790; rs9914209; rs12951519; rs12603230; rs9913775; rs8068408; rs12452455; rs9901373; rs3063349; rs9913682; rs3785503; rs34156759; rs34776810; rs10574223; rs34836173; rs12951434; rs9709057; rs28813401; rs36146846; rs34709982; rs28616155; rs8082379; rs35267848; rs12951289; rs12948357; rs12950577; rs35861887; rs12948747; rs35096596; rs8080408; rs9898042; rs35930947; rs12948751; rs5741757; rs9889355; rs35575792; rs34018072; rs34407368; rs4985764; rs11395505; rs34676851; rs12951504; rs12950929; rs34025151; rs3837806; rs34247865; rs12946386; rs34209605; rs7219953; rs12951983; rs11400183; rs9912599; rs36056059; rs8071972; rs35039203; rs35326975; rs8071718; rs12946113; rs1009720; rs10852850; rs11078381; rs11078386; rs11871699; rs12450758; rs12451886; rs12452946; rs12602578; rs16961593; rs16961599; rs17648393; rs183596; rs190261; rs2041393; rs2058292; rs2191383; rs242246; rs242247; rs242249; rs242250; rs242251; rs624242; rs6502572; rs8067390; rs9892592; rs9899615; rs9905458; rs9909800; rs9914113

# Metabolic_Enzyme_1_General_References:
10899995; 12352955

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5802

# Metabolic_Enzyme_2_Name:
Cytidine deaminase

# Metabolic_Enzyme_2_Synonyms:
Cytidine aminohydrolase

# Metabolic_Enzyme_2_Gene_Name:
CDA

# Metabolic_Enzyme_2_Protein_Sequence:
>Cytidine deaminase
MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACY
PLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKP
DGTYIVMTVQELLPSSFGPEDLQKTQ

# Metabolic_Enzyme_2_Number_of_Residues:
146

# Metabolic_Enzyme_2_Molecular_Weight:
16185

# Metabolic_Enzyme_2_Theoretical_pI:
6.95

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  cytidine deaminase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleoside metabolism
Process:  pyrimidine nucleoside metabolism
Process:  pyrimidine ribonucleoside metabolism
Process:  cytidine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis

# Metabolic_Enzyme_2_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_2_Reaction:
cytidine + H2O = uridine + ammonia

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00383:dCMP_cyt_deam_1

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.5.4.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
598149

# Metabolic_Enzyme_2_SwissProt_ID:
CDD_HUMAN (P32320)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
CDA

# Metabolic_Enzyme_2_Geneatlas_id:
CDA

# Metabolic_Enzyme_2_hgnc_id:
HGNC:1712

# Metabolic_Enzyme_2_PDB_ID:
1MQ0

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_2_Gene_Sequence:
>441 bp
ATGGCCCAGAAGCGTCCTGCCTGCACCCTGAAGCCTGAGTGTGTCCAGCAGCTGCTGGTT
TGCTCCCAGGAGGCCAAGAAGTCAGCCTACTGCCCCTACAGTCACTTTCCTGTGGGGGCT
GCCCTGCTCACCCAGGAGGGGAGAATCTTCAAAGGGTGCAACATAGAAAATGCCTGCTAC
CCGCTGGGCATCTGTGCTGAACGGACCGCTATCCAGAAGGCCGTCTCAGAAGGGTACAAG
GATTTCAGGGCAATTGCTATCGCCAGTGACATGCAAGATGATTTTATCTCTCCATGTGGG
GCCTGCAGGCAAGTCATGAGAGAGTTTGGCACCAACTGGCCCGTGTACATGACCAAGCCG
GATGGTACGTATATTGTCATGACGGTCCAGGAGCTGCTGCCCTCCTCCTTTGGGCCTGAG
GACCTGCAGAAGACTCAGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
L27943

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_2_Locus:
1p36.2-p35

# Metabolic_Enzyme_2_SNPs:
rs2072671; rs1048977; rs602950; rs1781459; rs818194; rs12402391; rs818199; rs818196; rs558946; rs580032; rs818207; rs1689924; rs10916824; rs3738130; rs527912; rs10799647; rs577042; rs10916829; rs12404655; rs818193; rs498617; rs1253920; rs572529; rs818192; rs818197; rs477155; rs589942; rs12036993; rs517483; rs10916828; rs818198; rs11579252; rs471760; rs2985316; rs7523472; rs4655226; rs6659399; rs10916825; rs7548190; rs11579101; rs12407778; rs7534998; rs11578210; rs1781461; rs12068596; rs12119998; rs11583986; rs7535303; rs10799648; rs7523547; rs10916826; rs563329; rs12406106; rs11580375; rs818200; rs12072405; rs12120002; rs7523557; rs11801036; rs588485; rs7535200; rs7513317; rs1253921; rs7537463; rs488991; rs617782; rs10916827; rs7515668; rs500534; rs557219; rs818201; rs526987; rs10916830; rs12127536; rs506586; rs7537761; rs12072407; rs2320237; rs11582454; rs12401770; rs546692; rs11580377; rs542038; rs12072411; rs10916831; rs7545140; rs472629; rs573337; rs818202; rs1253904; rs532545; rs6690069; rs10916832; rs10916833; rs10916822; rs552722; rs603412; rs17854868; rs35163879; rs3215400; rs528031; rs1048980; rs34306899; rs602946; rs35247557; rs5772909; rs35125816; rs35859441; rs36002777; rs12131589; rs34293111; rs35045423; rs36106578; rs34634228; rs35916142; rs12123808; rs12145503; rs34652519; rs12029060; rs11584381; rs35668998; rs7414028; rs35869652; rs11589869; rs9970283; rs28646077; rs35735696; rs12030776; rs12036909; rs35182793; rs12141867; rs12075735; rs12722974; rs1253482; rs12022958; rs34008190; rs10628782; rs12737642; rs6676236; rs34347193; rs12072318; rs12059454; rs12119997; rs12125531; rs12401583; rs1152993; rs35187698; rs4655228; rs34809737; rs6679821; rs35806956; rs12039573; rs34822300; rs1253481; rs12024909; rs6657978; rs11272233; rs11579996; rs35088359; rs34840123; rs34904959; rs818206; rs12120392; rs35234793; rs34988653; rs6688783; rs41467355; rs12740823; rs11591189; rs9970233; rs6665553; rs35285740; rs1689925; rs34995697; rs12143372; rs28591485; rs34722632; rs11334996; rs3072072; rs9970226; rs12029033; rs35351279; rs12731069; rs11580211; rs28743049; rs12752560; rs692943; rs12123445; rs12135846; rs34901070; rs35637551; rs35770611; rs34861922; rs5772908; rs34862360; rs7531198; rs12092374; rs4259612; rs1689926; rs12744559; rs12737656; rs34715988; rs4655227; rs34918162; rs34185271; rs12045976; rs10916823; rs12240109; rs12726436; rs476790; rs12117048; rs33942385; rs10601038; rs12095662; rs10711308; rs12128671; rs10753504; rs10916836; rs10916837; rs1572487; rs1614627; rs1689916; rs1781457; rs485716; rs485833; rs540282; rs586422; rs650264; rs652536; rs6687370; rs6695655; rs678980; rs680748

# Metabolic_Enzyme_2_General_References:
7923172; 9878810; 9596658; 8422236

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5237

# Metabolic_Enzyme_3_Name:
Cytosolic purine 5'-nucleotidase

# Metabolic_Enzyme_3_Synonyms:
5'-nucleotidase cytosolic II

# Metabolic_Enzyme_3_Gene_Name:
NT5C2

# Metabolic_Enzyme_3_Protein_Sequence:
>Cytosolic purine 5'nucleotidase
MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVY
KSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLV
CAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTS
CETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMK
EVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGT
VLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKS
KKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQ
RRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAA
HVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLA
PQEITHCHDEDDDEEEEEEEE

# Metabolic_Enzyme_3_Number_of_Residues:
561

# Metabolic_Enzyme_3_Molecular_Weight:
64970

# Metabolic_Enzyme_3_Theoretical_pI:
6.05

# Metabolic_Enzyme_3_GO_Classification:
Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_3_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF05761:5_nucleotid

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_3_GenBank_ID_Protein:
633071

# Metabolic_Enzyme_3_SwissProt_ID:
5NTC_HUMAN (P49902)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
NT5C2

# Metabolic_Enzyme_3_Geneatlas_id:
NT5C2

# Metabolic_Enzyme_3_hgnc_id:
HGNC:8022

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>1686 bp
ATGTCGACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGAT
AAGCATGCCCTGAAAAAGTATCGTCGAGAAGCCTATCATCGGGTGTTTGTGAACCGAAGT
TTAGCAATGGAAAAGATAAAGTGTTTTGGTTTTGATATGGATTATACCCTTGCTGTGTAC
AAGTCCCCAGAGTATGAGTCCCTTGGTTTTGAGCTTACTGTGGAGAGATTAGTTTCTATT
GGCTATCCCCAGGAGTTGCTCAGCTTTGCTTATGATTCTACATTCCCTACCAGGGGACTT
GTCTTTGACACACTGTATGGAAATCTTTTGAAAGTCGATGCCTATGGAAACCTCTTGGTC
TGTGCACATGGATTTAACTTTATAAGGGGACCAGAAACTAGAGAACAGTATCCAAATAAA
TTTATCCAGCGAGATGATACTGAAAGATTTTACATTCTGAACACACTATTCAACCTACCA
GAGACCTACCTGTTGGCCTGCCTAGTAGATTTTTTTACTAATTGTCCCAGATATACCAGT
TGTGAAACAGGATTTAAAGATGGGGACCTCTTCATGTCCTACCGGAGTATGTTCCAGGAT
GTAAGAGATGCTGTTGACTGGGTTCATTACAAGGGCTCCCTTAAGGAAAAGACAGTTGAA
AATCTTGAGAAGTATGTAGTCAAAGATGGAAAACTGCCTTTGCTTCTGAGCCGGATGAAG
GAAGTAGGGAAAGTATTTCTTGCTACCAACAGTGACTATAAATATACAGATAAAATTATG
ACTTACCTGTTTGACTTCCCACATGGCCCCAAGCCTGGGAGCTCCCATCGACCATGGCAG
TCCTACTTTGACTTGATCTTGGTGGATGCACGGAAACCACTCTTTTTTGGAGAAGGCACA
GTACTGCGTCAGGTGGATACTAAAACTGGCAAGCTGAAAATTGGTACCTACACAGGGCCC
CTACAGCATGGTATCGTCTACTCAGGAGGTTCTTCTGATACGATCTGTGACCTGTTGGGA
GCCAAGGGAAAAGACATTTTGTATATTGGAGATCACATTTTTGGGGACATTTTAAAATCA
AAGAAACGGCAAGGGTGGCGAACTTTTTTGGTGATTCCTGAACTCGCACAGGAGCTACAT
GTCTGGACTGACAAGAGTTCACTTTTCGAAGAACTTCAGAGCTTGGATATTTTCTTGGCT
GAACTCTACAAGCATCTTGACAGCAGTAGCAATGAGCGTCCAGACATCAGTTCCATCCAG
AGACGTATTAAGAAAGTAACTCATGACATGGACATGTGCTATGGGATGATGGGAAGCCTG
TTTCGCAGTGGCTCCCGGCAGACCCTTTTTGCCAGTCAAGTGATGCGTTATGCTGACCTC
TATGCAGCATCTTTCATCAACCTGCTGTATTACCCTTTCAGCTACCTCTTCAGGGCTGCC
CATGTCTTGATGCCTCATGAATCAACGGTGGAGCACACACACGTAGATATCAATGAGATG
GAGTCTCCTCTTGCCACCCGGAACCGCACATCAGTGGATTTCAAAGACACTGACTACAAG
CGGCACCAGCTGACACGGTCAATTAGTGAGATTAAACCTCCCAACCTCTTCCCACTGGCC
CCCCAGGAAATTACACACTGCCATGACGAAGATGATGATGAAGAGGAGGAGGAGGAGGAA
GAATAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
D38524

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_3_Locus:
10q24.32-q24.33

# Metabolic_Enzyme_3_SNPs:
rs12262171; rs3740387; rs12253627; rs10786736; rs8139; rs7917650; rs10786741; rs7920251; rs10430665; rs7916854; rs12573199; rs11191598; rs1163238; rs12573200; rs10883843; rs7092407; rs12573221; rs4917997; rs11191593; rs11191596; rs10786744; rs1163236; rs10883842; rs10786742; rs10786743; rs7075552; rs7077097; rs2863728; rs3758543; rs7077291; rs10748838; rs3087681; rs12240508; rs732998; rs10883830; rs7899084; rs2274340; rs2182348; rs2066322; rs7908960; rs7912517; rs7067970; rs3740386; rs7896547; rs11191554; rs1163249; rs2281877; rs2863727; rs3781281; rs2274341; rs2148198; rs7897663; rs3781282; rs10883832; rs1926029; rs1935323; rs1926030; rs746293; rs6584539; rs2066323; rs9919482; rs3740385; rs12773916; rs12414232; rs10786737; rs12413046; rs12412038; rs2274339; rs11598702; rs1541213; rs11191580; rs11191553; rs10509765; rs10509766; rs3977751; rs12220375; rs4917996; rs7896433; rs6584540; rs1926037; rs3736922; rs11191577; rs2148197; rs11191561; rs7080935; rs11191555; rs10883833; rs12219304; rs1926036; rs7913920; rs10883834; rs11191558; rs11191582; rs11191589; rs10883831; rs12220743; rs10786738; rs11191560; rs10748837; rs11191578; rs3781280; rs7896519; rs12217501; rs11191573; rs7067741; rs6584541; rs7067663; rs2148200; rs10883840; rs11191583; rs12415199; rs9919485; rs11191557; rs17094683; rs7895154; rs12355120; rs2153774; rs10786739; rs7915816; rs7081075; rs1807298; rs3861984; rs11191572; rs12571568; rs12416331; rs11191586; rs10883839; rs12766205; rs1163239; rs10883837; rs11191584; rs1163247; rs17115452; rs11191556; rs7909022; rs12775302; rs9633712; rs11191581; rs11191576; rs10883836; rs11191549; rs7095304; rs10883845; rs11191550; rs11191548; rs11191602; rs10748839; rs1141101; rs1055812; rs1141100; rs1141098; rs1141099; rs34351688; rs34394526; rs34058246; rs11191594; rs35224704; rs34747231; rs12774207; rs11191595; rs34699185; rs11280184; rs1163237; rs7073259; rs34064597; rs11191601; rs35525740; rs35291480; rs12264098; rs35978588; rs12241986; rs7091462; rs12774182; rs34756486; rs35695488; rs12252236; rs3834416; rs11191600; rs34136949; rs7080242; rs12763243; rs34003851; rs11191585; rs11191551; rs36111455; rs34966121; rs35464534; rs35541240; rs11191571; rs35913488; rs34223002; rs11440429; rs41287482; rs35653865; rs34963818; rs11191559; rs11191568; rs35436872; rs17795366; rs1163246; rs34060908; rs34963563; rs34915846; rs12780509; rs2153773; rs34211645; rs3736924; rs34758128; rs36059537; rs35302704; rs12255989; rs34104646; rs11191574; rs11191564; rs35745742; rs34644789; rs5787481; rs34863357; rs11191590; rs12774840; rs2148196; rs12763944; rs3215816; rs34207290; rs35752695; rs34445719; rs28419708; rs4421684; rs28516969; rs12265498; rs12767422; rs12772228; rs34908445; rs11191570; rs17115449; rs35195396; rs12243923; rs10883835; rs12779263; rs11302933; rs7091173; rs11375439; rs7071103; rs35146429; rs35338839; rs34268365; rs34130454; rs35898850; rs3861983; rs28404041; rs35621207; rs3736923; rs5787482; rs7075048; rs34307431; rs35348020; rs34349473; rs1773930; rs11191566; rs34870452; rs35078544; rs35123178; rs12265545; rs1163241; rs3949893; rs7904067; rs12775841; rs35821867; rs12775904; rs7915032; rs5028036; rs35254502; rs1163248; rs35365027; rs34876862; rs11191565; rs12772280; rs10709724; rs35085852; rs35351555; rs12774513; rs10710371; rs11296588; rs12243903; rs28605898; rs34241930; rs34549427; rs11451961; rs34403968; rs12761657; rs34397864; rs3062737; rs36092020; rs35109679; rs34011916; rs34435560; rs11191562; rs4917383; rs34067380; rs34202831; rs11191563; rs2148199; rs34133379; rs35763505; rs12414385; rs1163240; rs12262258; rs11191588; rs34664715; rs12414374; rs35133717; rs3837340; rs10614009; rs2153772; rs11191587; rs11403586; rs11191575; rs1060240; rs34588165; rs11191552; rs41317254; rs1163245; rs1064099; rs12268552; rs34833988; rs11191603; rs12253716; rs12412924; rs3841710; rs34551510; rs12246784; rs12781668; rs1064098; rs10458729; rs10786740; rs10786745; rs10883829; rs10883841; rs11191547; rs1163235; rs12261294; rs12571345; rs12785223; rs17115427; rs4307650; rs4917382; rs4917995; rs7074395; rs7092200; rs726010; rs763914; rs7921996; rs943035

# Metabolic_Enzyme_3_General_References:
7999131

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5803

# Metabolic_Enzyme_4_Name:
Activation-induced cytidine deaminase

# Metabolic_Enzyme_4_Synonyms:
Cytidine aminohydrolase

# Metabolic_Enzyme_4_Gene_Name:
AICDA

# Metabolic_Enzyme_4_Protein_Sequence:
>Activationinduced cytidine deaminase
MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSLDFGYLRNKNGCHVELL
FLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTARLYFCEDRK
AEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFKAWEGLHENSVRLSRQLRRIL
LPLYEVDDLRDAFRTLGL

# Metabolic_Enzyme_4_Number_of_Residues:
198

# Metabolic_Enzyme_4_Molecular_Weight:
23954

# Metabolic_Enzyme_4_Theoretical_pI:
9.66

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses

# Metabolic_Enzyme_4_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_4_Reaction:
cytidine + H2O = uridine + ammonia

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF05240:APOBEC_C;
PF08210:APOBEC_N

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.5.4.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
9988410

# Metabolic_Enzyme_4_SwissProt_ID:
AICDA_HUMAN (Q9GZX7)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
AICDA

# Metabolic_Enzyme_4_Geneatlas_id:
AICDA

# Metabolic_Enzyme_4_hgnc_id:
HGNC:13203

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_4_Gene_Sequence:
>597 bp
ATGGACAGCCTCTTGATGAACCGGAGGAAGTTTCTTTACCAATTCAAAAATGTCCGCTGG
GCTAAGGGTCGGCGTGAGACCTACCTGTGCTACGTAGTGAAGAGGCGTGACAGTGCTACA
TCCTTTTCACTGGACTTTGGTTATCTTCGCAATAAGAACGGCTGCCACGTGGAATTGCTC
TTCCTCCGCTACATCTCGGACTGGGACCTAGACCCTGGCCGCTGCTACCGCGTCACCTGG
TTCACCTCCTGGAGCCCCTGCTACGACTGTGCCCGACATGTGGCCGACTTTCTGCGAGGG
AACCCCAACCTCAGTCTGAGGATCTTCACCGCGCGCCTCTACTTCTGTGAGGACCGCAAG
GCTGAGCCCGAGGGGCTGCGGCGGCTGCACCGCGCCGGGGTGCAAATAGCCATCATGACC
TTCAAAGATTATTTTTACTGCTGGAATACTTTTGTAGAAAACCATGAAAGAACTTTCAAA
GCCTGGGAAGGGCTGCATGAAAATTCAGTTCGTCTCTCCAGACAGCTTCGGCGCATCCTT
TTGCCCCTGTATGAGGTTGATGACTTACGAGACGCATTTCGTACTTTGGGACTTTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AB040431

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_4_Locus:
12p13

# Metabolic_Enzyme_4_SNPs:
rs2028373; rs12307097; rs11046349; rs7304723; rs2580874; rs2518144; rs2580873; rs1561560; rs2580875; rs12306110; rs1561559; rs2580876; rs3794318; rs17792729; rs1347978; rs3794316; rs1439868; rs2165191; rs3794317; rs11613792; rs1561562; rs1561561; rs714629; rs7316523; rs9971686; rs1561557; rs12297074; rs2019057; rs9971703; rs714630; rs3205190; rs10601618; rs34604633; rs11324989; rs7138990; rs35273657; rs10623739; rs12310085; rs28681214; rs11614281; rs5796316; rs1439869; rs12307620; rs34730872; rs12312451; rs5796317; rs33998240; rs35699718; rs1982214; rs12321976; rs34030304; rs1561558; rs1345004; rs9971705; rs28835914; rs12321209; rs12824576; rs2889653; rs7305961; rs7306108

# Metabolic_Enzyme_4_General_References:
10950930; 11007475; 11544457

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5232

# Metabolic_Enzyme_5_Name:
Cytosolic 5'-nucleotidase 1B

# Metabolic_Enzyme_5_Synonyms:
Cytosolic 5'-nucleotidase IB; cN1B; cN-IB; Autoimmune infertility-related protein

# Metabolic_Enzyme_5_Gene_Name:
NT5C1B

# Metabolic_Enzyme_5_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
BMSQTSLKQKKNEPGMRSSKESLEAEKRKESDKTGVRLSNQMRRAVNPNHSLRCCPFQGH
SSCRRCLCAAEGTALGPCHTIRIYIHMCLLWEQGQQITMMRGSQESSLRKTDSRGYLVRS
QWSRISRSPSTKAPSIDEPRSRNTSAKLPSSSTSSRTPSTSPSLHDSSPPPLSGQPSLQP
PASPQLPRSLDSRPPTPPEPDPGSRRSTKMQENPEAWAQGIVREIRQTRDSQPLEYSRTS
PTEWKSSSQRRGIYPASTQLDRNSLSEQQQQQREDEDDYEAAYWASMRSFYEKNPSCSRP
WPPKPKNAITIALSSCALFNMVDGRKIYEQEGLEKYMEYQLTNENVILTPGPAFRFVKAL
QYVNARLRDLYPDEQDLFDIVLMTNNHAQVGVRLINSVNHYGLLIDRFCLTGGKDPIGYL
KAYLTNLYIAADSEKVQEAIQEGIASATMFDGAKDMAYCDTQLRVAFDGDAVLFSDESEH
FTKEHGLDKFFQYDTLCESKPLAQGPLKGFLEDLGRLQKKFYAKNERLLCPIRTYLVTAR
SAASSGARVLKTLRRWGLEIDEALFLAGAPKSPILVKIRPHIFFDDHMFHIEGAQRLGSI
AAYGFNKKFSS

# Metabolic_Enzyme_5_Number_of_Residues:
610

# Metabolic_Enzyme_5_Molecular_Weight:
68804

# Metabolic_Enzyme_5_Theoretical_pI:
9.03

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels

# Metabolic_Enzyme_5_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_5_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_5_GenBank_ID_Protein:
13774961

# Metabolic_Enzyme_5_SwissProt_ID:
5NT1B_HUMAN (Q96P26)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
NT5C1B

# Metabolic_Enzyme_5_Geneatlas_id:
NT5C1B

# Metabolic_Enzyme_5_hgnc_id:
HGNC:17818

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1699 bp
GGGCAAAAATGTGGATAACAACAAAAGAATTTCAACAGGTAAAAAAATGAGTCAAACATC
TCTCAAACAGAAAAAGAATGAGCCCGGAATGAGGTCCTCAAAAGAGAGTCTAGAAGCAGA
AAAAAGAAAGGAATCTGACAAAACAGGAGTTCGTCTGAGCAATCAGGGATCACAAGAATC
ATCACTGCGGAAGACAGACTCTCGAGGGTACCTTGTGCGCAGTCAATGGTCTAGAATATC
CCGGAGCCCATCCACCAAGGCTCCATCCATAGATGAGCCTAGAAGCAGGAACACCAGTGC
TAAGCTCCCCAGCAGCTCCACGAGCTCCCGGACTCCATCCACCTCCCCAAGCCTGCATGA
CTCCTCACCGCCGCCGCTGTCCGGGCAGCCCTCGCTCCAGCCACCCGCGTCGCCCCAGCT
GCCCCGGTCGCTGGACTCGCGGCCTCCCACGCCCCCAGAGCCCGATCCTGGCTCCCGGCG
CAGCACCAAAATGCAAGAAAATCCGGAGGCCTGGGCCCAAGGCATCGTGCGGGAAATCCG
CCAGACCCGGGACTCGCAGCCGCTGGAATATTCGCGCACGTCCCCCACCGAGTGGAAGTC
CTCCAGCCAGCGCAGGGGGATCTACCCCGCCTCCACCCAGCTGGACCGCAACTCTCTGTC
CGAGCAGCAGCAGCAGCAGCGGGAGGACGAAGACGACTACGAAGCTGCCTACTGGGCATC
CATGAAGTCGTTCTACGAAAAGAACCCGAGCTGCTGGCGCCCCTGGCCGCCCAAACCCAA
GAACGCCATCACCATTGCTCTCTCATCCTGCGCGCTCTTCAACATGGTGGACGGCAGGAA
AATCTACGAGCAAGAGGGTCTGGAAAAGTACATGGAGTATCAGCTCACCAATGAGAACGT
CATCCTGACCCCGGGCCCGGCGTTCCGTTTCGTCAAGGCACTACAGTATGTCAATGCTAG
ACTCCGTGATCTATATCCTGATGAACAGGACTTATTTGATATTGTACTGATGACTAATAA
CCATGCCCAAGTGGGAGTGCGGCTTATAAACAGCGTCAATCACTACGGCTTACTGATTGA
CCGCTTCTGTCTGACCGGGGGAAAAGACCCCATTGGCTATTTGAAGGCATATCTTACCAA
CTTGTATATTGCTGCAGATTCTGAAAAAGTGCAAGAGGCAATACAAGAAGGTATTGCCTC
TGCGACAATGTTTGATGGAGCCAAAGACATGGCTTACTGTGACACTCAGCTCCGTGTAGC
CTTTGATGGGGATGCTGTCCTCTTCTCTGATGAGTCTGAACATTTTACCAAGGAGCATGG
GCTGGACAAATTCTTCCAGTATGATACATTATGTGAAAGTAAGCCTCTTGCTCAGGGTCC
CCTAAAAGGCTTTCTGGAAGATTTAGGCAGACTGCAAAAGAAGTTCTATGCCAAAAATGA
ACGGTTACTTTGTCCTATCAGGACCTACCTGGTTACAGCTAGGAGTGCAGCCAGTTCAGG
CGCCCGTGTGCTGAAAACCTTCCGACGCTGGGGTCTAGAGATAGACGAAGCTCTTTTCCT
TGCTGGAGCCCCCAAAAGTCCCATCTTGGTGAAGATCCGGCCCCACATCTTCTTTGATGA
CCACATGTTCCACATTGAAGGGGCACAGAGGTTAGGTTCCATCGCAGCTTATGGCTTTAA
TAAAAAATTCAGTAGTTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AF356185

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_5_Locus:
2p24.2

# Metabolic_Enzyme_5_SNPs:
rs3902946; rs16985301; rs16985306; rs3747660; rs2346137; rs6720633; rs7594728; rs6531109; rs6710367; rs7557821; rs4832608; rs11893074; rs16985296; rs7561652; rs2317857; rs16985292; rs16985290; rs6741218; rs11096544; rs35590292; rs10183289; rs17752103; rs11885013; rs17701334; rs16985293; rs11903725; rs7604190; rs4832609; rs7592099; rs16985311; rs16985310; rs3810839; rs17852342; rs34254789; rs7594519; rs34129467; rs7605480; rs35165251; rs7603601; rs34836771; rs34186303; rs35711606; rs35729409; rs34953851; rs11291136; rs28474708; rs3046807; rs34660980; rs35519366; rs3046840; rs35419885; rs7557722; rs4300829; rs7592233; rs13020403; rs36121694; rs34127788; rs11889898; rs13403096; rs13411442; rs1373776; rs16985281; rs16985284; rs17751951; rs2346135; rs2346136; rs34722188; rs35805648; rs3810838; rs3910894

# Metabolic_Enzyme_5_General_References:
11690631

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5229

# Metabolic_Enzyme_6_Name:
5'-nucleotidase precursor

# Metabolic_Enzyme_6_Synonyms:
Ecto-5'-nucleotidase; 5'-NT; CD73 antigen

# Metabolic_Enzyme_6_Gene_Name:
NT5E

# Metabolic_Enzyme_6_Protein_Sequence:
>5'nucleotidase precursor
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ

# Metabolic_Enzyme_6_Number_of_Residues:
574

# Metabolic_Enzyme_6_Molecular_Weight:
63368

# Metabolic_Enzyme_6_Theoretical_pI:
7.04

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  hydrolase activity, acting on ester bonds
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides

# Metabolic_Enzyme_6_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_6_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF02872:5_nucleotid_C;
PF00149:Metallophos

# Metabolic_Enzyme_6_Signals:
1-26

# Metabolic_Enzyme_6_Transmembrane_Regions:
556-573

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_6_GenBank_ID_Protein:
23897

# Metabolic_Enzyme_6_SwissProt_ID:
5NTD_HUMAN (P21589)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
NT5E

# Metabolic_Enzyme_6_Geneatlas_id:
NT5E

# Metabolic_Enzyme_6_hgnc_id:
HGNC:8021

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Metabolic_Enzyme_6_Gene_Sequence:
>1725 bp
ATGTGTCCCCGAGCCGCGCGGGCGCCCGCGACGCTACTCCTCGCCCTGGGCGCGGTGCTG
TGGCCTGCGGCTGGCGCCTGGGAGCTTACGATTTTGCACACCAACGACGTGCACAGCCGG
CTGGAGCAGACCAGCGAGGACTCCAGCAAGTGCGTCAACGCCAGCCGCTGCATGGGTGGC
GTGGCTCGGCTCTTCACCAAGGTTCAGCAGATCCGCCGCGCCGAACCCAACGTGCTGCTG
CTGGACGCCGGCGACCAGTACCAGGGCACTATCTGGTTCACCGTGTACAAGGGCGCCGAG
GTGGCGCACTTCATGAACGCCCTGCGCTACGATGCCATGGCACTGGGAAATCATGAATTT
GATAATGGTGTGGAAGGACTGATCGAGCCACTCCTCAAAGAGGCCAAATTTCCAATTCTG
AGTGCAAACATTAAAGCAAAGGGGCCACTAGCATCTCAAATATCAGGACTTTATTTGCCA
TATAAAGTTCTTCCTGTTGGTGATGAAGTTGTGGGAATCGTTGGATACACTTCCAAAGAA
ACCCCTTTTCTCTCAAATCCAGGGACAAATTTAGTGTTTGAAGATGAAATCACTGCATTA
CAACCTGAAGTAGATAAGTTAAAAACTCTAAATGTGAACAAAATTATTGCACTGGGACAT
TCGGGTTTTGAAATGGATAAACTCATCGCTCAGAAAGTGAGGGGTGTGGACGTCGTGGTG
GGAGGACACTCCAACACATTTCTTTACACAGGCAATCCACCTTCCAAAGAGGTGCCTGCT
GGGAAGTACCCATTCATAGTCACTTCTGATGATGGGCGGAAGGTTCCTGTAGTCCAGGCC
TATGCTTTTGGCAAATACCTAGGCTATCTGAAGATCGAGTTTGATGAAAGAGGAAACGTC
ATCTCTTCCCATGGAAATCCCATTCTTCTAAACAGCAGCATTCCTGAAGATCCAAGCATA
AAAGCAGACATTAACAAATGGAGGATAAAATTGGATAATTATTCTACCCAGGAATTAGGG
AAAACAATTGTCTATCTGGATGGCTCCTCTCAATCATGCCGCTTTAGAGAATGCAACATG
GGCAACCTGATTTGTGATGCAATGATTAACAACAACCTGAGACACACGGATGAAATGTTC
TGGAACCACGTATCCATGTGCATTTTAAATGGAGGTGGTATCCGGTCGCCCATTGATGAA
CGCAACAATGGCACAATTACCTGGGAGAACCTGGCTGCTGTATTGCCCTTTGGAGGCACA
TTTGACCTAGTCCAGTTAAAAGGTTCCACCCTGAAGAAGGCCTTTGAGCATAGCGTGCAC
CGCTACGGCCAGTCCACTGGAGAGTTCCTGCAGGTGGGCGGAATCCATGTGGTGTATGAT
CTTTCCCGAAAACCTGGAGACAGAGTAGTCAAATTAGATGTTCTTTGCACCAAGTGTCGA
GTGCCCAGTTATGACCCTCTCAAAATGGACGAGGTATATAAGGTGATCCTCCCAAACTTC
CTGGCCAATGGTGGAGATGGGTTCCAGATGATAAAAGATGAATTATTAAGACATGACTCT
GGTGACCAAGATATCAACGTGGTTTCTACATATATCTCCAAAATGAAAGTAATTTATCCA
GCAGTTGAAGGTCGGATCAAGTTTTCCACAGGAAGTCACTGCCATGGAAGCTTTTCTTTA
ATATTTCTTTCACTTTGGGCAGTGATCTTTGTTTTATACCAATAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
X55740

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_6_Locus:
6q14-q21

# Metabolic_Enzyme_6_SNPs:
Not Available

# Metabolic_Enzyme_6_General_References:
2129526; 8566797; 2173922; 9651114

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5337

# Metabolic_Enzyme_7_Name:
Uridine-cytidine kinase 1

# Metabolic_Enzyme_7_Synonyms:
UCK 1; Uridine monophosphokinase 1; Cytidine monophosphokinase 1

# Metabolic_Enzyme_7_Gene_Name:
UCK1

# Metabolic_Enzyme_7_Protein_Sequence:
>Uridinecytidine kinase 1
MASAGGEDCESPAPEADRPHQRPFLIGVSGGTASGKSTVCEKIMELLGQNEVEQRQRKVV
ILSQDRFYKVLTAEQKAKALKGQYNFDHPDAFDNDLMHRTLKNIVEGKTVEVPTYDFVTH
SRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDVRRGRDL
EQILTQYTTFVKPAFEEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDILNGDICKWHR
GGSNGRSYKRTFSEPGDHPGMLTSGKRSHLESSSRPH

# Metabolic_Enzyme_7_Number_of_Residues:
277

# Metabolic_Enzyme_7_Molecular_Weight:
31435

# Metabolic_Enzyme_7_Theoretical_pI:
7.33

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleoside kinase activity
Function:  uridine kinase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, 4-N-acetylcytidine, 4-N- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and 4-N-anisoylcytidine

# Metabolic_Enzyme_7_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_7_Reaction:
ATP + uridine = ADP + UMP

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00485:PRK

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.7.1.48

# Metabolic_Enzyme_7_GenBank_ID_Protein:
13506765

# Metabolic_Enzyme_7_SwissProt_ID:
UCK1_HUMAN (Q9HA47)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
UCK1

# Metabolic_Enzyme_7_Geneatlas_id:
UCK1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:14859

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>834 bp
ATGGCTTCGGCGGGAGGCGAAGACTGCGAGAGCCCCGCGCCGGAGGCCGACCGTCCGCAC
CAGCGGCCCTTCCTGATAGGGGTGAGCGGCGGCACTGCCAGCGGGAAGTCGACCGTGTGT
GAGAAGATCATGGAGTTGCTGGGACAGAACGAGGTGGAACAGCGGCAGCGGAAGGTGGTC
ATCCTGAGCCAGGACAGGTTCTACAAGGTCCTGACGGCAGAGCAGAAGGCCAAGGCCTTG
AAAGGACAGTACAATTTTGACCATCCAGATGCCTTTGATAATGATTTGATGCACAGGACT
CTGAAGAACATCGTGGAGGGCAAAACGGTGGAGGTGCCGACCTATGATTTTGTGACACAC
TCAAGGTTACCAGAGACCACGGTGGTCTACCCTGCGGACGTGGTTCTGTTTGAGGGCATC
TTGGTGTTCTACAGCCAGGAGATCCGGGACATGTTCCACCTGCGCCTCTTCGTGGACACC
GACTCCGACGTCAGGCTGTCTCGAAGAGTTCTCCGGGACGTGCGCCGAGGGAGGGACCTG
GAGCAGATTCTGACGCAGTACACCACCTTCGTGAAGCCGGCCTTCGAGGAGTTCTGCCTG
CCGACAAAGAAGTATGCCGATGTGATCATCCCGCGAGGAGTGGACAATATGGTTGCCATC
AACCTGATCGTGCAGCACATCCAGGACATTCTGAATGGTGACATCTGCAAATGGCACCGA
GGAGGGTCCAATGGGCGGAGCTACAAGCGGACCTTTTCTGAGCCAGGGGACCACCCTGGG
ATGCTGACCTCTGGCAAACGGTCACATTTGGAGTCCAGCAGCAGACCCCACTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AF237290

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_7_Locus:
9q34.13

# Metabolic_Enzyme_7_SNPs:
rs2296957; rs35991434; rs6597502; rs4740260; rs10793886; rs10793887; rs6597503; rs7859459; rs3808830; rs9785228; rs3904961; rs12682945; rs35345663; rs10609062; rs34523479; rs7869614; rs12377531; rs36042195; rs36102623; rs34811006; rs34625466; rs11440136; rs5900943; rs35542333; rs7862845; rs4292738; rs35582001; rs7040906; rs12684413; rs10257; rs1052561; rs10698; rs10793885; rs11005; rs11023; rs11243406; rs11243408; rs12003400; rs12115566; rs12551562; rs14188; rs1547768; rs17537644; rs2010635; rs2277152; rs2277153; rs2282010; rs2282011; rs2296956; rs3183977; rs34492185; rs34954751; rs3739495; rs3824395; rs3904960; rs4113141; rs4740165; rs4740257; rs4740259; rs4740263; rs7849433; rs7867616; rs7868519; rs7870715; rs946713

# Metabolic_Enzyme_7_General_References:
11306702

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5233

# Metabolic_Enzyme_8_Name:
Cytosolic 5'-nucleotidase 1A

# Metabolic_Enzyme_8_Synonyms:
Cytosolic 5'-nucleotidase IA; cN1A; cN-IA; cN-I

# Metabolic_Enzyme_8_Gene_Name:
NT5C1A

# Metabolic_Enzyme_8_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
AMEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSR
ALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSED
VFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKV
REAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKA
HENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSW
GLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTA
PAKQAPSAQ

# Metabolic_Enzyme_8_Number_of_Residues:
368

# Metabolic_Enzyme_8_Molecular_Weight:
41021

# Metabolic_Enzyme_8_Theoretical_pI:
6.52

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia

# Metabolic_Enzyme_8_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_8_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_8_GenBank_ID_Protein:
12659324

# Metabolic_Enzyme_8_SwissProt_ID:
5NT1A_HUMAN (Q9BXI3)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
NT5C1A

# Metabolic_Enzyme_8_Geneatlas_id:
NT5C1A

# Metabolic_Enzyme_8_hgnc_id:
HGNC:17819

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_8_Gene_Sequence:
>1107 bp
ATGGAACCTGGGCAGCCCCGGGAGCCCCAGGAGCCCCGCGAGCCCGGGCCAGGAGCGGAG
ACCGCTGCGGCCCCGGTCTGGGAGGAAGCCAAGATTTTCTACGACAACCTCGCGCCCAAG
AAGAAACCCAAATCGCCCAAGCCTCAGAATGCAGTCACCATCGCTGTGTCCTCCCGAGCC
TTGTTTCGCATGGACGAGGAGCAGCAGATCTACACGGAGCAGGGCGTGGAGGAGTACGTG
CGCTACCAGCTGGAACATGAGAACGAACCCTTCAGTCCCGGGCCAGCCTTCCCTTTTGTG
AAGGCTCTGGAGGCCGTGAACAGGCGGCTGCGGGAGCTGTACCCTGATAGTGAGGACGTC
TTCGACATCGTCCTCATGACTAACAACCATGCTCAAGTGGGTGTCCGCCTCATCAACAGT
ATCAACCACTATGACCTGTTCATCGAGAGGTTCTGCATGACAGGTGGGAACAGCCCGATC
TGCTACCTCAAGGCCTATCACACCAACCTCTACTTGTCAGCCGATGCGGAAAAAGTGCGA
GAAGCCATTGATGAGGGGATCGCAGCTGCCACCATCTTCAGCCCCAGCAGGGATGTGGTT
GTGTCCCAGAGTCAGCTGCGCGTGGCCTTCGATGGGGACGCCGTGCTCTTCTCGGACGAG
TCGGAGCGCATCGTCAAGGCCCACGGGCTGGACCGATTCTTCGAGCATGAGAAGGCCCAC
GAGAACAAGCCTCTGGCTCAGGGCCCCTTAAAGGGCTTTCTGGAGGCACTGGGTAGGTTG
CAGAAGAAGTTCTACTCCAAAGGCCTGCGGCTGGAGTGCCCAATTCGTACCTACTTGGTG
ACAGCACGCAGTGCAGCCAGTTCCGGGGCCCGGGCTCTCAAGACCCTGCGCAGCTGGGGC
CTGGAGACAGATGAAGCCTTGTTCCTTGCTGGAGCGCCCAAGGGCCCTCTCCTTGAGAAG
ATCCGCCCACACATCTTCTTTGATGACCAGATGTTCCATGTGGCTGGGGCTCAGGAGATG
GGCACTGTGGCCGCCCATGTGCCTTATGGTGTGGCACAGACACCCCGGCGGACTGCACCT
GCAAAGCAGGCCCCATCTGCACAGTAG

# Metabolic_Enzyme_8_GenBank_ID_Gene:
AF331801

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_8_Locus:
1p34.3-p33

# Metabolic_Enzyme_8_SNPs:
rs4660340; rs784611; rs752667; rs1180272; rs1180271; rs784595; rs873917; rs1568146; rs1535031; rs3851911; rs17264901; rs784596; rs12566856; rs12406284; rs11807200; rs784597; rs784610; rs734497; rs3806428; rs784600; rs11809004; rs7553293; rs3806433; rs16826428; rs9660121; rs784599; rs3806429; rs784612; rs1533479; rs2871601; rs41264507; rs34479837; rs12035327; rs1180270; rs9439008; rs35574502; rs34779558; rs36025518; rs36123767; rs35625235; rs28507686; rs35550484; rs11206573; rs41264509; rs784598; rs34604809; rs1535030; rs5773668; rs1517187; rs12039176; rs28592113; rs784594; rs9438930; rs11306359; rs35355327; rs6684666; rs34908371; rs28667717; rs3806432; rs5773667; rs7416372; rs34045723; rs6672154; rs35002774; rs35256759; rs3806431; rs12042601; rs10465833; rs1062103; rs10839; rs10888919; rs10888929; rs11206525; rs1180275; rs1180277; rs12039225; rs12042356; rs12565281; rs13315; rs16826440; rs17501838; rs17560858; rs2281302; rs2746057; rs3207766; rs3806434; rs3916165; rs6663003; rs6703320; rs704769; rs736009; rs7419080; rs784601; rs784602; rs784613; rs784615; rs784616; rs784627; rs784629; rs784630; rs813052

# Metabolic_Enzyme_8_General_References:
11133996

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5234

# Metabolic_Enzyme_9_Name:
5'(3')-deoxyribonucleotidase, cytosolic type

# Metabolic_Enzyme_9_Synonyms:
Cytosolic 5',3'-pyrimidine nucleotidase; Deoxy-5'-nucleotidase 1; dNT-1

# Metabolic_Enzyme_9_Gene_Name:
NT5C

# Metabolic_Enzyme_9_Protein_Sequence:
>5'3'deoxyribonucleotidase, cytosolic type
MARSVRVLVDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADK
VASVYEAPGFFLDLEPIPGALDAVREMNDLPDTQVFICTSPLLKYHHCVGEKYRWVEQHL
GPQFVERIILTRDKTVVLGDLLIDDKDTVRGQEETPSWEHILFTCCHNRHLVLPPTRRRL
LSWSDNWREILDSKRGAAQRE

# Metabolic_Enzyme_9_Number_of_Residues:
201

# Metabolic_Enzyme_9_Molecular_Weight:
23383

# Metabolic_Enzyme_9_Theoretical_pI:
6.63

# Metabolic_Enzyme_9_GO_Classification:
Not Available

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP

# Metabolic_Enzyme_9_Pathway:
Not Available

# Metabolic_Enzyme_9_Reaction:
Not Available

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_9_GenBank_ID_Protein:
7524492

# Metabolic_Enzyme_9_SwissProt_ID:
NT5C_HUMAN (Q8TCD5)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
NT5C

# Metabolic_Enzyme_9_Geneatlas_id:
NT5C

# Metabolic_Enzyme_9_hgnc_id:
HGNC:17144

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_9_Gene_Sequence:
>606 bp
ATGGCGCGGAGCGTGCGCGTGCTGGTGGACATGGACGGCGTCCTGGCCGACTTCGAGGCC
GGCCTCCTGCGGGGCTTCCGCCGCCGCTTCCCTGAGGAGCCGCACGTGCCGCTGGAGCAA
CGCCGCGGCTTCCTGGCCCGCGAGCAGTACCGCGCCCTGCGGCCCGACCTGGCGGATAAA
GTGGCCAGTGTGTACGAAGCCCCGGGCTTTTTCCTGGACCTGGAGCCCATCCCGGGAGCC
TTGGACGCTGTGCGGGAGATGAACGACCTACCGGACACGCAGGTCTTCATCTGCACCAGC
CCCCTGCTGAAGTACCACCACTGTGTGGGTGAGAAGTACCGCTGGGTGGAGCAGCACCTG
GGGCCCCAGTTCGTAGAACGAATTATCCTGACAAGGGACAAGACGGTGGTCTTGGGGGAC
CTGCTCATTGATGACAAGGACACAGTTCGAGGCCAGGAGGAGACCCCAAGCTGGGAGCAC
ATCTTGTTCACCTGCTGCCACAATCGGCACCTGGTCCTGCCCCCGACAAGGAGACGGCTG
CTCTCCTGGAGTGACAACTGGAGGGAGATCTTAGATAGCAAGCGCGGAGCTGCGCAGCGG
GAATGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AF154829

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_9_Locus:
17q25.1

# Metabolic_Enzyme_9_SNPs:
rs4788867; rs11868451; rs3736076; rs3736075; rs12453556; rs4789144; rs11652099; rs4789143; rs11541956; rs12945569; rs3188816; rs12946860; rs1048779; rs12943507; rs34746270; rs11541955; rs12945517; rs9910084; rs34454120; rs7406461; rs4788868; rs11868212; rs1551966; rs2291027; rs2291028; rs34338273; rs3752801; rs4412997; rs4789145; rs750843; rs750844; rs899316; rs899317

# Metabolic_Enzyme_9_General_References:
10681516; 12234672

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
8749

# Metabolic_Enzyme_10_Name:
Cytosolic 5'-nucleotidase III

# Metabolic_Enzyme_10_Synonyms:
cN-III; Pyrimidine 5'- nucleotidase 1; P5'N-1; P5N-1; PN-I; Uridine 5'-monophosphate hydrolase 1; p36

# Metabolic_Enzyme_10_Gene_Name:
NT5C3

# Metabolic_Enzyme_10_Protein_Sequence:
>Cytosolic 5'nucleotidase 
IIIMRAPSMDRAAVARVGAVASASVCALVAGVVLAQYIFTLKRKTGRKTKIIEMMPEFQK
SSVRIKNPTRVEEIICGLIKGGAAKLQIITDFDMTLSRFSYKGKRCPTCHNIIDNCKLVT
DECRKKLLQLKEKYYAIEVDPVLTVEEKYPYMVEWYTKSHGLLVQQALPKAKLKEIVAES
DVMLKEGYENFFDKLQQHSIPVFIFSAGIGDVLEEVIRQAGVYHPNVKVVSNFMDFDETG
VLKGFKGELIHVFNKHDGALRNTEYFNQLKDNSNIILLGDSQGDLRMADGVANVEHILKI
GYLNDRVDELLEKYMDSYDIVLVQDESLEVANSILQKIL

# Metabolic_Enzyme_10_Number_of_Residues:
336

# Metabolic_Enzyme_10_Molecular_Weight:
37949

# Metabolic_Enzyme_10_Theoretical_pI:
7.15

# Metabolic_Enzyme_10_GO_Classification:
Not Available

# Metabolic_Enzyme_10_General_Function:
Not Available

# Metabolic_Enzyme_10_Specific_Function:
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate

# Metabolic_Enzyme_10_Pathway:
map00230  Purine metabolism
 map00240  Pyrimidine metabolism
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_10_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF05822:UMPH-1

# Metabolic_Enzyme_10_Signals:
1-32

# Metabolic_Enzyme_10_Transmembrane_Regions:
13-35

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_10_GenBank_ID_Protein:
11245474

# Metabolic_Enzyme_10_SwissProt_ID:
5NT3_HUMAN (Q9H0P0)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
NT5C3

# Metabolic_Enzyme_10_Geneatlas_id:
NT5C3

# Metabolic_Enzyme_10_hgnc_id:
HGNC:17820

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cytoplasm (Potential). Isoform 2:Endoplasmic reticulum

# Metabolic_Enzyme_10_Gene_Sequence:
>861 bp
ATGATGCCAGAATTCCAGAAAAGTTCAGTTCGAATCAAGAACCCTACAAGAGTAGAAGAA
ATTATCTGTGGTCTTATCAAAGGAGGAGCTGCCAAACTTCAGATAATAACGGACTTTGAT
ATGACACTCAGTAGATTTTCATATAAAGGGAAAAGATGCCCAACATGTCATAATATCATT
GACAACTGTAAGCTGGTTACAGATGAATGTAGAAAAAAGTTATTGCAACTAAAGGAAAAA
TACTACGCTATTGAAGTTGATCCTGTTCTTACTGTAGAAGAGAAGTACCCTTATATGGTG
GAATGGTATACTAAATCACATGGTTTGCTTGTTCAGCAAGCTTTACCAAAAGCTAAACTT
AAAGAAATTGTGGCAGAATCTGACGTTATGCTCAAAGAAGGATATGAGAATTTCTTTGAT
AAGCTCCAACAACATAGCATCCCCGTGTTCATATTTTCGGCTGGAATCGGCGATGTACTA
GAGGAAGTTATTCGTCAAGCTGGTGTTTATCATCCCAATGTCAAAGTTGTGTCCAATTTT
ATGGATTTTGATGAAACTGGGGTGCTCAAAGGATTTAAAGGAGAACTAATTCATGTATTT
AACAAACATGATGGTGCCTTGAGGAATACAGAATATTTCAATCAACTAAAAGACAATAGT
AACATAATTCTTCTGGGAGACTCCCAAGGAGACTTAAGAATGGCAGATGGAGTGGCCAAT
GTTGAGCACATTCTGAAAATTGGATATCTAAATGATAGAGTGGATGAGCTTTTAGAAAAG
TACATGGACTCTTATGATATTGTTTTAGTACAAGATGAATCATTAGAAGTAGCCAACTCT
ATTTTACAGAAGATTCTATAA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
AF312735

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_10_Locus:
7p14.3

# Metabolic_Enzyme_10_SNPs:
rs3750117; rs17170223; rs7806813; rs6946062; rs4723241; rs7792135; rs6415262; rs7795860; rs7796184; rs4723242; rs10230500; rs4723239; rs6462452; rs10085768; rs10256717; rs4338000; rs6462453; rs10233749; rs10281012; rs10280692; rs10251079; rs7801986; rs4720098; rs7778958; rs10951370; rs6948212; rs6462451; rs10231011; rs4316067; rs10951371; rs7800610; rs4445128; rs7803427; rs6948759; rs6976301; rs17170264; rs6954923; rs6968519; rs1609410; rs6956397; rs7776847; rs4723240; rs10241653; rs17170228; rs1881749; rs10807866; rs12534758; rs12672785; rs7801701; rs4720100; rs10486512; rs10951372; rs12672827; rs6954699; rs12532475; rs10238911; rs10247806; rs1609543; rs1881750; rs6947507; rs12536321; rs1609407; rs6946539; rs2049758; rs3750119; rs4720097; rs2392208; rs2893457; rs6462449; rs3750118; rs6955792; rs10242882; rs4723235; rs4562213; rs2392211; rs6462450; rs7793793; rs4236335; rs2392209; rs6942974; rs3793328; rs12155477; rs2392210; rs17385980; rs4723234; rs6965942; rs10270155; rs12668520; rs4720095; rs10269519; rs17170218; rs4565371; rs4286846; rs6961785; rs7798138; rs17170153; rs7798538; rs10951369; rs10240662; rs6962945; rs3793329; rs11532669; rs17170151; rs3793331; rs6462448; rs10267080; rs16879126; rs17170172; rs7790368; rs17170180; rs7788623; rs3793330; rs11767244; rs7809021; rs4720094; rs11974256; rs17470890; rs6462445; rs7792057; rs6462446; rs6462444; rs10266244; rs10262141; rs13438699; rs17170045; rs6976843; rs35152518; rs12113572; rs35420404; rs11769843; rs12111676; rs28623683; rs35671236; rs10582278; rs11760453; rs7779477; rs17471190; rs11453440; rs5883381; rs6462454; rs34316079; rs34195150; rs2392214; rs6943638; rs7810269; rs13222705; rs36169043; rs12533799; rs2893460; rs35152276; rs11390691; rs10254146; rs35691055; rs35109630; rs17471162; rs11547833; rs35207287; rs11382973; rs11395770; rs5883380; rs35818020; rs11390690; rs1581684; rs10582277; rs28728209; rs28473079; rs17471313; rs3082829; rs6943893; rs13224861; rs11395769; rs11382972; rs28501096; rs17471224; rs34813051; rs11773636; rs35338263; rs11388536; rs11414093; rs2392212; rs11407169; rs34974224; rs11392423; rs12531081; rs2893459; rs13222706; rs35390311; rs13237339; rs35666265; rs4720099; rs12666128; rs6968844; rs10584675; rs2392213; rs34121210; rs10586164; rs10260952; rs34311705; rs34135622; rs28439161; rs17471015; rs10691796; rs6965006; rs28622104; rs34838392; rs11407650; rs12154853; rs4723236; rs28619883; rs34938098; rs7782604; rs34359635; rs4720096; rs11336828; rs35180909; rs34628314; rs28382383; rs34862244; rs36051367; rs36110783; rs28576352; rs11439369; rs6963198; rs7797997; rs34317509; rs4723238; rs35312649; rs34834341; rs4000127; rs11437974; rs5883379; rs28506936; rs34501041; rs36099404; rs6965241; rs17470945; rs4000126; rs35588427; rs12155117; rs11434167; rs34416274; rs35769309; rs11286607; rs4723237; rs34947432; rs2893458; rs17470792; rs13228827; rs10248436; rs13228639; rs34307182; rs34567230; rs10252880; rs10253348; rs12538619; rs2893461; rs2893462; rs4330597; rs4394301; rs4454197; rs4604334; rs4720093; rs4723232; rs4723233; rs4723244; rs6953386; rs7802256

# Metabolic_Enzyme_10_General_References:
10942414; 11230166; 11042152; 8557639

# Metabolic_Enzyme_10_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7522

# Macromolecular_Interacting_Partner_1_Name:
Sodium/nucleoside cotransporter 2

# Macromolecular_Interacting_Partner_1_Synonyms:
Na(+/nucleoside cotransporter 2; Sodium-coupled nucleoside transporter 2; Concentrative nucleoside transporter 2; CNT 2; hCNT2; Sodium/purine nucleoside co- transporter; SPNT

# Macromolecular_Interacting_Partner_1_Gene_Name:
SLC28A2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Sodium/nucleoside cotransporter 2
MEKASGRQSIALSTVETGTVNPGLELMEKEVEPEGSKRTDAQGHSLGDGLGPSTYQRRSR
WPFSKARSFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVH
SFLKKLLGKKLTRCLKPFENSRLRLWTKWVFAGVSLVGLILWLALDTAQRPEQLIPFAGI
CMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYT
VAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTA
TETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDAS
SLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLA
TNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMV
AEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLS
SIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGILYVPRGAEADCVSFPN
TSFTNRTYETYMCCRGLFQSTSLNGTNPPSFSGPWEDKEFSAMALTNCCGFYNNTVCA

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
658

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
71927

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
8.00

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  binding
Function:  nucleoside binding
Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
Function:  nucleoside:sodium symporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Nucleotide transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF07670:Gate;
PF07662:Nucleos_tra2_C;
PF01773:Nucleos_tra2_N

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
80-100
104-123
148-166
172-192
200-220
233-253
260-280
295-314
336-355
362-381
423-443
454-474
529-549
567-587

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
2731439

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
S28A2_HUMAN (O43868)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
SLC28A2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
SLC28A2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:11002

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1977 bp
ATGGAGAAAGCAAGTGGAAGACAGTCCATTGCTCTGTCCACAGTGGAGACTGGCACAGTG
AACCCGGGGCTGGAGCTCATGGAAAAAGAAGTAGAGCCTGAGGGAAGCAAGAGGACTGAC
GCACAAGGACACAGCCTGGGGGATGGACTGGGCCCTTCCACTTACCAGAGGAGGAGTCGG
TGGCCTTTCAGCAAAGCAAGAAGTTTCTGCAAAACACACGCCAGATTGTTCAAGAAGATC
CTGTTGGGCCTGTTGTGTTTGGCCTATGCTGCCTATCTCCTGGCAGCTTGCATCTTGAAT
TTCCAGAGGGCACTGGCCTTGTTTGTCATCACCTGCTTGGTGATCTTTGTCCTGGTTCAC
TCGTTTTTGAAAAAGCTCCTGGGCAAAAAATTAACAAGATGTCTGAAGCCCTTTGAAAAC
TCCCGCCTGAGGCTTTGGACGAAATGGGTGTTTGCAGGAGTCTCCTTGGTTGGCCTTATA
CTGTGGTTGGCTTTAGACACAGCCCAAAGGCCAGAGCAGCTGATCCCCTTTGCAGGAATC
TGCATGTTCATCCTTATCCTCTTTGCCTGCTCCAAACACCACAGCGCAGTGTCCTGGAGG
ACAGTGTTTTCGGGCCTAGGTCTTCAATTTGTCTTTGGGATCTTGGTCATCAGAACTGAT
CTTGGATATACTGTATTTCAGTGGCTGGGAGAGCAGGTCCAGATTTTCCTGAACTACACT
GTGGCCGGCTCCAGTTTTGTCTTTGGGGATACACTGGTCAAGGATGTCTTTGCTTTTCAG
GCCTTACCAATCATCATTTTCTTTGGATGTGTGGTGTCCATTCTCTACTACCTGGGCCTG
GTGCAATGGGTAGTTCAGAAGGTCGCCTGGTTTTTACAAATCACTATGGGCACCACTGCT
ACAGAGACCCTGGCTGTGGCAGGAAACATCTTTGTGGGTATGACAGAGGCACCTCTGCTC
ATCCGTCCCTACCTTGGGGACATGACACTCTCTGAAATCCATGCGGTGATGACTGGAGGG
TTTGCCACCATTTCTGGCACTGTGCTGGGAGCCTTCATAGCCTTTGGGGTTGATGCATCA
TCCCTGATTTCTGCCTCTGTGATGGCCGCCCCTTGTGCTCTCGCCTCATCAAAGCTAGCG
TATCCGGAAGTGGAGGAGTCCAAGTTCAAGAGTGAGGAGGGGGTAAAGCTGCCCCGTGGG
AAGGAGAGGAATGTCCTGGAAGCTGCCAGCAACGGAGCCGTAGATGCCATAGGCCTTGCT
ACTAATGTAGCAGCCAACCTGATTGCCTTTTTGGCTGTGTTGGCCTTCATCAATGCTGCC
CTCTCCTGGCTGGGGGAATTGGTGGACATACAGGGGCTCACTTTCCAGGTCATCTGCTCC
TATCTCCTAAGGCCCATGGTTTTCATGATGGGTGTAGAGTGGACAGACTGTCCAATGGTG
GCTGAGATGGTGGGAATCAAGTTCTTCATAAATGAGTTTGTGGCTTATCAGCAACTGTCT
CAATACAAGAACAAACGTCTCTCTGGAATGGAGGAGTGGATTGAGGGAGAGAAACAGTGG
ATTTCTGTGAGAGCTGAAATCATTACAACATTTTCACTCTGTGGATTTGCCAATCTTAGT
TCCATAGGAATCACACTTGGAGGCTTGACATCAATAGTACCTCACCGGAAGAGTGACTTG
TCCAAGGTTGTGGTCAGGGCCCTCTTCACAGGGGCCTGTGTATCCCTTATCAGTGCCTGT
ATGGCAGGAATCCTCTATGTCCCCAGGGGAGCTGAAGCTGACTGTGTCTCCTTCCCAAAC
ACAAGTTTCACCAATAGAACCTATGAGACCTACATGTGCTGCAGAGGGCTCTTTCAGAGT
ACTTCTCTGAATGGCACCAACCCTCCTTCTTTTTCTGGTCCCTGGGAAGATAAGGAGTTC
AGTGCTATGGCCCTTACTAACTGCTGTGGATTCTACAACAATACCGTCTGTGCCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
U84392

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:15

# Macromolecular_Interacting_Partner_1_Locus:
15q15

# Macromolecular_Interacting_Partner_1_SNPs:
rs1060896; rs2271437; rs17215633; rs10519020; rs8023604; rs16941032; rs2458225; rs2413770; rs2413768; rs2271438; rs11854365; rs11632419; rs1706766; rs8039354; rs6493142; rs8040185; rs11629807; rs11854325; rs10519018; rs2413772; rs11639420; rs8037583; rs11632920; rs11629859; rs16941213; rs9972443; rs11637838; rs2413769; rs11632752; rs16941238; rs2413774; rs11632778; rs12913645; rs11631021; rs12915314; rs8041702; rs11629858; rs9921035; rs8039540; rs8039138; rs16941188; rs11637920; rs12911186; rs8039352; rs12904150; rs16941245; rs16941118; rs7162022; rs16941127; rs12910143; rs8033629; rs9920290; rs11632777; rs7163607; rs8033317; rs11632651; rs12899942; rs9921025; rs11632724; rs12440356; rs16941242; rs2413773; rs2899377; rs2413775; rs3759895; rs10162724; rs11639349; rs2413776; rs2413777; rs3759892; rs2899376; rs3759893; rs16941017; rs11639483; rs9635306; rs2458226; rs34506049; rs35110548; rs11639255; rs35561718; rs35194204; rs4774554; rs34449510; rs12898818; rs12899058; rs12901747; rs3047538; rs12908581; rs28559620; rs35093502; rs35221909; rs34537209; rs8040518; rs2413771; rs34575502; rs12898652; rs34962914; rs28694123; rs12911861; rs33940589; rs12443261; rs11381433; rs35665816; rs35643725; rs36077721; rs8039610; rs28524974; rs35235740; rs34158146; rs35227239; rs11636410; rs11854484; rs12440623; rs12908818; rs13380236; rs16941355; rs1706767; rs1706768; rs1706769; rs1706770; rs1706773; rs1719231; rs1719236; rs17215591; rs17215605; rs17215626; rs17215654; rs17222036; rs17222057; rs17222078; rs2413779; rs2413780; rs2413781; rs2461705; rs4492985; rs4774550; rs6493144; rs6493145; rs7165039; rs7166580; rs7167146; rs7171312; rs8024620

# Macromolecular_Interacting_Partner_1_General_References:
9435697; 10087507; 10455109

# Macromolecular_Interacting_Partner_1_References:
16828706

# Macromolecular_Interacting_Partner_2_ID:
7562

# Macromolecular_Interacting_Partner_2_Name:
Apolipoprotein B-100 precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Apo B-100[Contains: Apolipoprotein B-48; Apo B-48]

# Macromolecular_Interacting_Partner_2_Gene_Name:
APOB

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Apolipoprotein B100 precursor
MDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAES
SSGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSE
EFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLFLD
TVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLIS
SSQSCQYTLDAKRKHVAEAICKEQHLFLPFSYNNKYGMVAQVTQTLKLEDTPKINSRFFG
EGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGLSD
EAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPE
PSAQQLREIFNMARDQRSRATLYALSHAVNNYHKTNPTGTQELLDIANYLMEQIQDDCTG
DEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKDKD
QEVLLQTFLDDASPGDKRLAAYLMLMRSPSQADINKIVQILPWEQNEQVKNFVASHIANI
LNSEELDIQDLKKLVKEALKESQLPTVMDFRKFSRNYQLYKSVSLPSLDPASAKIEGNLI
FDPNNYLPKESMLKTTLTAFGFASADLIEIGLEGKGFEPTLEALFGKQGFFPDSVNKALY
WVNGQVPDGVSKVLVDHFGYTKDDKHEQDMVNGIMLSVEKLIKDLKSKEVPEARAYLRIL
GEELGFASLHDLQLLGKLLLMGARTLQGIPQMIGEVIRKGSKNDFFLHYIFMENAFELPT
GAGLQLQISSSGVIAPGAKAGVKLEVANMQAELVAKPSVSVEFVTNMGIIIPDFARSGVQ
MNTNFFHESGLEAHVALKAGKLKFIIPSPKRPVKLLSGGNTLHLVSTTKTEVIPPLIENR
QSWSVCKQVFPGLNYCTSGAYSNASSTDSASYYPLTGDTRLELELRPTGEIEQYSVSATY
ELQREDRALVDTLKFVTQAEGAKQTEATMTFKYNRQSMTLSSEVQIPDFDVDLGTILRVN
DESTEGKTSYRLTLDIQNKKITEVALMGHLSCDTKEERKIKGVISIPRLQAEARSEILAH
WSPAKLLLQMDSSATAYGSTVSKRVAWHYDEEKIEFEWNTGTNVDTKKMTSNFPVDLSDY
PKSLHMYANRLLDHRVPETDMTFRHVGSKLIVAMSSWLQKASGSLPYTQTLQDHLNSLKE
FNLQNMGLPDFHIPENLFLKSDGRVKYTLNKNSLKIEIPLPFGGKSSRDLKMLETVRTPA
LHFKSVGFHLPSREFQVPTFTIPKLYQLQVPLLGVLDLSTNVYSNLYNWSASYSGGNTST
DHFSLRARYHMKADSVVDLLSYNVQGSGETTYDHKNTFTLSCDGSLRHKFLDSNIKFSHV
EKLGNNPVSKGLLIFDASSSWGPQMSASVHLDSKKKQHLFVKEVKIDGQFRVSSFYAKGT
YGLSCQRDPNTGRLNGESNLRFNSSYLQGTNQITGRYEDGTLSLTSTSDLQSGIIKNTAS
LKYENYELTLKSDTNGKYKNFATSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLN
SHGLELNADILGTDKINSGAHKATLRIGQDGISTSATTNLKCSLLVLENELNAELGLSGA
SMKLTTNGRFREHNAKFSLDGKAALTELSLGSAYQAMILGVDSKNIFNFKVSQEGLKLSN
DMMGSYAEMKFDHTNSLNIAGLSLDFSSKLDNIYSSDKFYKQTVNLQLQPYSLVTTLNSD
LKYNALDLTNNGKLRLEPLKLHVAGNLKGAYQNNEIKHIYAISSAALSASYKADTVAKVQ
GVEFSHRLNTDIAGLASAIDMSTNYNSDSLHFSNVFRSVMAPFTMTIDAHTNGNGKLALW
GEHTGQLYSKFLLKAEPLAFTFSHDYKGSTSHHLVSRKSISAALEHKVSALLTPAEQTGT
WKLKTQFNNNEYSQDLDAYNTKDKIGVELTGRTLADLTLLDSPIKVPLLLSEPINIIDAL
EMRDAVEKPQEFTIVAFVKYDKNQDVHSINLPFFETLQEYFERNRQTIIVVVENVQRNLK
HINIDQFVRKYRAALGKLPQQANDYLNSFNWERQVSHAKEKLTALTKKYRITENDIQIAL
DDAKINFNEKLSQLQTYMIQFDQYIKDSYDLHDLKIAIANIIDEIIEKLKSLDEHYHIRV
NLVKTIHDLHLFIENIDFNKSGSSTASWIQNVDTKYQIRIQIQEKLQQLKRHIQNIDIQH
LAGKLKQHIEAIDVRVLLDQLGTTISFERINDVLEHVKHFVINLIGDFEVAEKINAFRAK
VHELIERYEVDQQIQVLMDKLVELTHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDA
VKKLNELSFKTFIEDVNKFLDMLIKKLKSFDYHQFVDETNDKIREVTQRLNGEIQALELP
QKAEALKLFLEETKATVAVYLESLQDTKITLIINWLQEALSSASLAHMKAKFRETLEDTR
DRMYQMDIQQELQRYLSLVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRMKAL
VEQGFTVPEIKTILGTMPAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKDLKNIK
IPSRFSTPEFTILNTFHIPSFTIDFVEMKVKIIRTIDQMQNSELQWPVPDIYLRDLKVED
IPLARITLPDFRLPEIAIPEFIIPTLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYS
ILKIQSPLFTLDANADIGNGTTSANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKIN
PLALKESVKFSSKYLRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNGVIVKINNQ
LTLDSNTKYFHKLNIPKLDFSSQADLRNEIKTLLKAGHIAWTSSGKGSWKWACPRFSDEG
THESQISFTIEGPLTSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHS
VLTAKGMALFGEGKAEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVRF
PLRLTGKIDFLNNYALFLSPSAQQASWQVSARFNQYKYNQNFSAGNNENIMEAHVGINGE
ANLDFLNIPLTIPEMRLPYTIITTPPLKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKN
KHRHSITNPLAVLCEFISQSIKSFDRHFEKNRNNALDFVTKSYNETKIKFDKYKAEKSHD
ELPRTFQIPGYTVPVVNVEVSPFTIEMSAFGYVFPKAVSMPSFSILGSDVRVPSYTLILP
SLELPVLHVPRNLKLSLPHFKELCTISHIFIPAMGNITYDFSFKSSVITLNTNAELFNQS
DIVAHLLSSSSSVIDALQYKLEGTTRLTRKRGLKLATALSLSNKFVEGSHNSTVSLTTKN
MEVSVAKTTKAEIPILRMNFKQELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVDHK
LSLESLTSYFSIESSTKGDVKGSVLSREYSGTIASEANTYLNSKSTRSSVKLQGTSKIDD
IWNLEVKENFAGEATLQRIYSLWEHSTKNHLQLEGLFFTNGEHTSKATLELSPWQMSALV
QVHASQPSSFHDFPDLGQEVALNANTKNQKIRWKNEVRIHSGSFQSQVELSNDQEKAHLD
IAGSLEGHLRFLKNIILPVYDKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPNGYSFS
IPVKVLADKFITPGLKLNDLNSVLVMPTFHVPFTDLQVPSCKLDFREIQIYKKLRTSSFA
LNLPTLPEVKFPEVDVLTKYSQPEDSLIPFFEITVPESQLTVSQFTLPKSVSDGIAALDL
NAVANKIADFELPTIIVPEQTIEIPSIKFSVPAGIVIPSFQALTARFEVDSPVYNATWSA
SLKNKADYVETVLDSTCSSTVQFLEYELNVLGTHKIEDGTLASKTKGTLAHRDFSAEYEE
DGKFEGLQEWEGKAHLNIKSPAFTDLHLRYQKDKKGISTSAASPAVGTVGMDMDEDDDFS
KWNFYYSPQSSPDKKLTIFKTELRVRESDEETQIKVNWEEEAASGLLTSLKDNVPKATGV
LYDYVNKYHWEHTGLTLREVSSKLRRNLQNNAEWVYQGAIRQIDDIDVRFQKAASGTTGT
YQEWKDKAQNLYQELLTQEGQASFQGLKDNVFDGLVRVTQKFHMKVKHLIDSLIDFLNFP
RFQFPGKPGIYTREELCTMFIREVGTVLSQVYSKVHNGSEILFSYFQDLVITLPFELRKH
KLIDVISMYRELLKDLSKEAQEVFKAIQSLKTTEVLRNLQDLLQFIFQLIEDNIKQLKEM
KFTYLINYIQDEINTIFNDYIPYVFKLLKENLCLNLHKFNEFIQNELQEASQELQQIHQY
IMALREEYFDPSIVGWTVKYYELEEKIVSLIKNLLVALKDFHSEYIVSASNFTSQLSSQV
EQFLHRNIQEYLSILTDPDGKGKEKIAELSATAQEIIKSQAIATKKIISDYHQQFRYKLQ
DFSDQLSDYYEKFIAESKRLIDLSIQNYHTFLIYITELLKKLQSTTVMNPYMKLAPGELT
IIL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
4563

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
515568

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
7.06

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  transporter activity
Function:  lipid transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  lipid transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Replication, recombination and repair 

# Macromolecular_Interacting_Partner_2_Specific_Function:
Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF06448:DUF1081;
PF09172:DUF1943;
PF01347:Vitellogenin_N

# Macromolecular_Interacting_Partner_2_Signals:
1-27

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
34331

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
APOB_HUMAN (P04114)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
APOB

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
APOB

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:603

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>13692 bp
ATGGACCCGCCGAGGCCCGCGCTGCTGGCGCTGCTGGCGCTGCCTGCGCTGCTGCTGCTG
CTGCTGGCGGGCGCCAGGGCCGAAGAGGAAATGCTGGAAAATGTCAGCCTGGTCTGTCCA
AAAGATGCGACCCGATTCAAGCACCTCCGGAAGTACACATACAACTATGAGGCTGAGAGT
TCCAGTGGAGTCCCTGGGACTGCTGATTCAAGAAGTGCCACCAGGATCAACTGCAAGGTT
GAGCTGGAGGTTCCCCAGCTCTGCAGCTTCATCCTGAAGACCAGCCAGTGCACCCTGAAA
GAGGTGTATGGCTTCAACCCTGAGGGCAAAGCCTTGCTGAAGAAAACCAAGAACTCTGAG
GAGTTTGCTGCAGCCATGTCCAGGTATGAGCTCAAGCTGGCCATTCCAGAAGGGAAGCAG
GTTTTCCTTTACCCGGAGAAAGATGAACCTACTTACATCCTGAACATCAAGAGGGGCATC
ATTTCTGCCCTCCTGGTTCCCCCAGAGACAGAAGAAGCCAAGCAAGTGTTGTTTCTGGAT
ACCGTGTATGGAAACTGCTCCACTCACTTTACCGTCAAGACGAGGAAGGGCAATGTGGCA
ACAGAAATATCCACTGAAAGAGACCTGGGGCAGTGTGATCGCTTCAAGCCCATCCGCACA
GGCATCAGCCCACTTGCTCTCATCAAAGGCATGACCCGCCCCTTGTCAACTCTGATCAGC
AGCAGCCAGTCCTGTCAGTACACACTGGACGCTAAGAGGAAGCATGTGGCAGAAGCCATC
TGCAAGGAGCAACACCTCTTCCTGCCTTTCTCCTACAACAATAAGTATGGGATGGTAGCA
CAAGTGACACAGACTTTGAAACTTGAAGACACACCAAAGATCAACAGCCGCTTCTTTGGT
GAAGGTACTAAGAAGATGGGCCTCGCATTTGAGAGCACCAAATCCACATCACCTCCAAAG
CAGGCCGAAGCTGTTTTGAAGACTCTCCAGGAACTGAAAAAACTAACCATCTCTGAGCAA
AATATCCAGAGAGCTAATCTCTTCAATAAGCTGGTTACTGAGCTGAGAGGCCTCAGTGAT
GAAGCAGTCACATCTCTCTTGCCACAGCTGATTGAGGTGTCCAGCCCCATCACTTTACAA
GCCTTGGTTCAGTGTGGACAGCCTCAGTGCTCCACTCACATCCTCCAGTGGCTGAAACGT
GTGCATGCCAACCCCCTTCTGATAGATGTGGTCACCTACCTGGTGGCCCTGATCCCCGAG
CCCTCAGCACAGCAGCTGCGAGAGATCTTCAACATGGCGAGGGATCAGCGCAGCCGAGCC
ACCTTGTATGCGCTGAGCCACGCGGTCAACAACTATCATAAGACAAACCCTACAGGGACC
CAGGAGCTGCTGGACATTGCTAATTACCTGATGGAACAGATTCAAGATGACTGCACTGGG
GATGAAGATTACACCTATTTGATTCTGCGGGTCATTGGAAATATGGGCCAAACCATGGAG
CAGTTAACTCCAGAACTCAAGTCTTCAATCCTCAAATGTGTCCAAAGTACAAAGCCATCA
CTGATGATCCAGAAAGCTGCCATCCAGGCTCTGCGGAAAATGGAGCCTAAAGACAAGGAC
CAGGAGGTTCTTCTTCAGACTTTCCTTGATGATGCTTCTCCGGGAGATAAGCGACTGGCT
GCCTATCTTATGTTGATGAGGAGTCCTTCACAGGCAGATATTAACAAAATTGTCCAAATT
CTACCATGGGAACAGAATGAGCAAGTGAAGAACTTTGTGGCTTCCCATATTGCCAATATC
TTGAACTCAGAAGAATTGGATATCCAAGATCTGAAAAAGTTAGTGAAAGAAGCTCTGAAA
GAATCTCAACTTCCAACTGTCATGGACTTCAGAAAATTCTCTCGGAACTATCAACTCTAC
AAATCTGTTTCTCTTCCATCACTTGACCCAGCCTCAGCCAAAATAGAAGGGAATCTTATA
TTTGATCCAAATAACTACCTTCCTAAAGAAAGCATGCTGAAAACTACCCTCACTGCCTTT
GGATTTGCTTCAGCTGACCTCATCGAGATTGGCTTGGAAGGAAAAGGCTTTGAGCCAACA
TTGGAAGCTCTTTTTGGGAAGCAAGGATTTTTCCCAGACAGTGTCAACAAAGCTTTGTAC
TGGGTTAATGGTCAAGTTCCTGATGGTGTCTCTAAGGTCTTAGTGGACCACTTTGGCTAT
ACCAAAGATGATAAACATGAGCAGGATATGGTAAATGGAATAATGCTCAGTGTTGAGAAG
CTGATTAAAGATTTGAAATCCAAAGAAGTCCCGGAAGCCAGAGCCTACCTCCGCATCTTG
GGAGAGGAGCTTGGTTTTGCCAGTCTCCATGACCTCCAGCTCCTGGGAAAGCTGCTTCTG
ATGGGTGCCCGCACTCTGCAGGGGATCCCCCAGATGATTGGAGAGGTCATCAGGAAGGGC
TCAAAGAATGACTTTTTTCTTCACTACATCTTCATGGAGAATGCCTTTGAACTCCCCACT
GGAGCTGGATTACAGTTGCAAATATCTTCATCTGGAGTCATTGCTCCCGGAGCCAAGGCT
GGAGTAAAACTGGAAGTAGCCAACATGCAGGCTGAACTGGTGGCAAAACCCTCCGTGTCT
GTGGAGTTTGTGACAAATATGGGCATCATCATTCCGGACTTCGCTAGGAGTGGGGTCCAG
ATGAACACCAACTTCTTCCACGAGTCGGGTCTGGAGGCTCATGTTGCCCTAAAAGCTGGG
AAGCTGAAGTTTATCATTCCTTCCCCAAAGAGACCAGTCAAGCTGCTCAGTGGAGGCAAC
ACATTACATTTGGTCTCTACCACCAAAACGGAGGTGATCCCACCTCTCATTGAGAACAGG
CAGTCCTGGTCAGTTTGCAAGCAAGTCTTTCCTGGCCTGAATTACTGCACCTCAGGCGCT
TACTCCAACGCCAGCTCCACAGACTCCGCCTCCTACTATCCGCTGACCGGGGACACCAGA
TTAGAGCTGGAACTGAGGCCTACAGGAGAGATTGAGCAGTATTCTGTCAGCGCAACCTAT
GAGCTCCAGAGAGAGGACAGAGCCTTGGTGGATACCCTGAAGTTTGTAACTCAAGCAGAA
GGTGCGAAGCAGACTGAGGCTACCATGACATTCAAATATAATCGGCAGAGTATGACCTTG
TCCAGTGAAGTCCAAATTCCGGATTTTGATGTTGACCTCGGAACAATCCTCAGAGTTAAT
GATGAATCTACTGAGGGCAAAACGTCTTACAGACTCACCCTGGACATTCAGAACAAGAAA
ATTACTGAGGTCGCCCTCATGGGCCACCTAAGTTGTGACACAAAGGAAGAAAGAAAAATC
AAGGGTGTTATTTCCATACCCCGTTTGCAAGCAGAAGCCAGAAGTGAGATCCTCGCCCAC
TGGTCGCCTGCCAAACTGCTTCTCCAAATGGACTCATCTGCTACAGCTTATGGCTCCACA
GTTTCCAAGAGGGTGGCATGGCATTATGATGAAGAGAAGATTGAATTTGAATGGAACACA
GGCACCAATGTAGATACCAAAAAAATGACTTCCAATTTCCCTGTGGATCTCTCCGATTAT
CCTAAGAGCTTGCATATGTATGCTAATAGACTCCTGGATCACAGAGTCCCTGAAACAGAC
ATGACTTTCCGGCACGTGGGTTCCAAATTAATAGTTGCAATGAGCTCATGGCTTCAGAAG
GCATCTGGGAGTCTTCCTTATACCCAGACTTTGCAAGACCACCTCAATAGCCTGAAGGAG
TTCAACCTCCAGAACATGGGATTGCCAGACTTCCACATCCCAGAAAACCTCTTCTTAAAA
AGCGATGGCCGGGTCAAATATACCTTGAACAAGAACAGTTTGAAAATTGAGATTCCTTTG
CCTTTTGGTGGCAAATCCTCCAGAGATCTAAAGATGTTAGAGACTGTTAGGACACCAGCC
CTCCACTTCAAGTCTGTGGGATTCCATCTGCCATCTCGAGAGTTCCAAGTCCCTACTTTT
ACCATTCCCAAGTTGTATCAACTGCAAGTGCCTCTCCTGGGTGTTCTAGACCTCTCCACG
AATGTCTACAGCAACTTGTACAACTGGTCCGCCTCCTACAGTGGTGGCAACACCAGCACA
GACCATTTCAGCCTTCGGGCTCGTTACCACATGAAGGCTGACTCTGTGGTTGACCTGCTT
TCCTACAATGTGCAAGGATCTGGAGAAACAACATATGACCACAAGAATACGTTCACACTA
TCATGTGATGGGTCTCTACGCCACAAATTTCTAGATTCGAATATCAAATTCAGTCATGTA
GAAAAACTTGGAAACAACCCAGTCTCAAAAGGTTTACTAATATTCGATGCATCTAGTTCC
TGGGGACCACAGATGTCTGCTTCAGTTCATTTGGACTCCAAAAAGAAACAGCATTTGTTT
GTCAAAGAAGTCAAGATTGATGGGCAGTTCAGAGTCTCTTCGTTCTATGCTAAAGGCACA
TATGGCCTGTCTTGTCAGAGGGATCCTAACACTGGCCGGCTCAATGGAGAGTCCAACCTG
AGGTTTAACTCCTCCTACCTCCAAGGCACCAACCAGATAACAGGAAGATATGAAGATGGA
ACCCTCTCCCTCACCTCCACCTCTGATCTGCAAAGTGGCATCATTAAAAATACTGCTTCC
CTAAAGTATGAGAACTACGAGCTGACTTTAAAATCTGACACCAATGGGAAGTATAAGAAC
TTTGCCACTTCTAACAAGATGGATATGACCTTCTCTAAGCAAAATGCACTGCTGCGTTCT
GAATATCAGGCTGATTACGAGTCATTGAGGTTCTTCAGCCTGCTTTCTGGATCACTAAAT
TCCCATGGTCTTGAGTTAAATGCTGACATCTTAGGCACTGACAAAATTAATAGTGGTGCT
CACAAGGCGACACTAAGGATTGGCCAAGATGGAATATCTACCAGTGCAACGACCAACTTG
AAGTGTAGTCTCCTGGTGCTGGAGAATGAGCTGAATGCAGAGCTTGGCCTCTCTGGGGCA
TCTATGAAATTAACAACAAATGGCCGCTTCAGGGAACACAATGCAAAATTCAGTCTGGAT
GGGAAAGCCGCCCTCACAGAGCTATCACTGGGAAGTGCTTATCAGGCCATGATTCTGGGT
GTCGACAGCAAAAACATTTTCAACTTCAAGGTCAGTCAAGAAGGACTTAAGCTCTCAAAT
GACATGATGGGCTCATATGCTGAAATGAAATTTGACCACACAAACAGTCTGAACATTGCA
GGCTTATCACTGGACTTCTCTTCAAAACTTGACAACATTTACAGCTCTGACAAGTTTTAT
AAGCAAACTGTTAATTTACAGCTACAGCCCTATTCTCTGGTAACTACTTTAAACAGTGAC
CTGAAATACAATGCTCTGGATCTCACCAACAATGGGAAACTACGGCTAGAACCCCTGAAG
CTGCATGTGGCTGGTAACCTAAAAGGAGCCTACCAAAATAATGAAATAAAACACATCTAT
GCCATCTCTTCTGCTGCCTTATCAGCAAGCTATAAAGCAGACACTGTTGCTAAGGTTCAG
GGTGTGGAGTTTAGCCATCGGCTCAACACAGACATCGCTGGGCTGGCTTCAGCCATTGAC
ATGAGCACAAACTATAATTCAGACTCACTGCATTTCAGCAATGTCTTCCGTTCTGTAATG
GCCCCGTTTACCATGACCATCGATGCACATACAAATGGCAATGGGAAACTCGCTCTCTGG
GGAGAACATACTGGGCAGCTGTATAGCAAATTCCTGTTGAAAGCAGAACCTCTGGCATTT
ACTTTCTCTCATGATTACAAAGGCTCCACAAGTCATCATCTCGTGTCTAGGAAAAGCATC
AGTGCAGCTCTTGAACACAAAGTCAGTGCCCTGCTTACTCCAGCTGAGCAGACAGGCACC
TGGAAACTCAAGACCCAATTTAACAACAATGAATACAGCCAGGACTTGGATGCTTACAAC
ACTAAAGATAAAATTGGCGTGGAGCTTACTGGACGAACTCTGGCTGACCTAACTCTACTA
GACTCCCCAATTAAAGTGCCACTTTTACTCAGTGAGCCCATCAATATCATTGATGCTTTA
GAGATGAGAGATGCCGTTGAGAAGCCCCAAGAATTTACAATTGTTGCTTTTGTAAAGTAT
GATAAAAACCAAGATGTTCACTCCATTAACCTCCCATTTTTTGAGACCTTGCAAGAATAT
TTTGAGAGGAATCGACAAACCATTATAGTTGTAGTGGAAAACGTACAGAGAAACCTGAAG
CACATCAATATTGATCAATTTGTAAGAAAATACAGAGCAGCCCTGGGAAAACTCCCACAG
CAAGCTAATGATTATCTGAATTCATTCAATTGGGAGAGACAAGTTTCACATGCCAAGGAG
AAACTGACTGCTCTCACAAAAAAGTATAGAATTACAGAAAATGATATACAAATTGCATTA
GATGATGCCAAAATCAACTTTAATGAAAAACTATCTCAACTGCAGACATATATGATACAA
TTTGATCAGTATATTAAAGATAGTTATGATTTACATGATTTGAAAATAGCTATTGCTAAT
ATTATTGATGAAATCATTGAAAAATTAAAAAGTCTTGATGAGCACTATCATATCCGTGTA
AATTTAGTAAAAACAATCCATGATCTACATTTGTTTATTGAAAATATTGATTTTAACAAA
AGTGGAAGTAGTACTGCATCCTGGATTCAAAATGTGGATACTAAGTACCAAATCAGAATC
CAGATACAAGAAAAACTGCAGCAGCTTAAGAGACACATACAGAATATAGACATCCAGCAC
CTAGCTGGAAAGTTAAAACAACACATTGAGGCTATTGATGTTAGAGTGCTTTTAGATCAA
TTGGGAACTACAATTTCATTTGAAAGAATAAATGATGTTCTTGAGCATGTCAAACACTTT
GTTATAAATCTTATTGGGGATTTTGAAGTAGCTGAGAAAATCAATGCCTTCAGAGCCAAA
GTCCATGAGTTAATCGAGAGGTATGAAGTAGACCAACAAATCCAGGTTTTAATGGATAAA
TTAGTAGAGTTGACCCACCAATACAAGTTGAAGGAGACTATTCAGAAGCTAAGCAATGTC
CTACAACAAGTTAAGATAAAAGATTACTTTGAGAAATTGGTTGGATTTATTGATGATGCT
GTGAAGAAGCTTAATGAATTATCTTTTAAAACATTCATTGAAGATGTTAACAAATTCCTT
GACATGTTGATAAAGAAATTAAAGTCATTTGATTACCACCAGTTTGTAGATGAAACCAAT
GACAAAATCCGTGAGGTGACTCAGAGACTCAATGGTGAAATTCAGGCTCTGGAACTACCA
CAAAAAGCTGAAGCATTAAAACTGTTTTTAGAGGAAACCAAGGCCACAGTTGCAGTGTAT
CTGGAAAGCCTACAGGACACCAAAATAACCTTAATCATCAATTGGTTACAGGAGGCTTTA
AGTTCAGCATCTTTGGCTCACATGAAGGCCAAATTCCGAGAGACTCTAGAAGATACACGA
GACCGAATGTATCAAATGGACATTCAGCAGGAACTTCAACGATACCTGTCTCTGGTAGGC
CAGGTTTATAGCACACTTGTCACCTACATTTCTGATTGGTGGACTCTTGCTGCTAAGAAC
CTTACTGACTTTGCAGAGCAATATTCTATCCAAGATTGGGCTAAACGTATGAAAGCATTG
GTAGAGCAAGGGTTCACTGTTCCTGAAATCAAGACCATCCTTGGGACCATGCCTGCCTTT
GAAGTCAGTCTTCAGGCTCTTCAGAAAGCTACCTTCCAGACACCTGATTTTATAGTCCCC
CTAACAGATTTGAGGATTCCATCAGTTCAGATAAACTTCAAAGACTTAAAAAATATAAAA
ATCCCATCCAGGTTTTCCACACCAGAATTTACCATCCTTAACACCTTCCACATTCCTTCC
TTTACAATTGACTTTGTCGAAATGAAAGTAAAGATCATCAGAACCATTGACCAGATGCAG
AACAGTGAGCTGCAGTGGCCCGTTCCAGATATATATCTCAGGGATCTGAAGGTGGAGGAC
ATTCCTCTAGCGAGAATCACCCTGCCAGACTTCCGTTTACCAGAAATCGCAATTCCAGAA
TTCATAATCCCAACTCTCAACCTTAATGATTTTCAAGTTCCTGACCTTCACATACCAGAA
TTCCAGCTTCCCCACATCTCACACACAATTGAAGTACCTACTTTTGGCAAGCTATACAGT
ATTCTGAAAATCCAATCTCCTCTTTTCACATTAGATGCAAATGCTGACATAGGGAATGGA
ACCACCTCAGCAAACGAAGCAGGTATCGCAGCTTCCATCACTGCCAAAGGAGAGTCCAAA
TTAGAAGTTCTCAATTTTGATTTTCAAGCAAATGCACAACTCTCAAACCCTAAGATTAAT
CCGCTGGCTCTGAAGGAGTCAGTGAAGTTCTCCAGCAAGTACCTGAGAACGGAGCATGGG
AGTGAAATGCTGTTTTTTGGAAATGCTATTGAGGGAAAATCAAACACAGTGGCAAGTTTA
CACACAGAAAAAAATACACTGGAGCTTAGTAATGGAGTGATTGTCAAGATAAACAATCAG
CTTACCCTGGATAGCAACACTAAATACTTCCACAAATTGAACATCCCCAAACTGGACTTC
TCTAGTCAGGCTGACCTGCGCAACGAGATCAAGACACTGTTGAAAGCTGGCCACATAGCA
TGGACTTCTTCTGGAAAAGGGTCATGGAAATGGGCCTGCCCCAGATTCTCAGATGAGGGA
ACACATGAATCACAAATTAGTTTCACCATAGAAGGACCCCTCACTTCCTTTGGACTGTCC
AATAAGATCAATAGCAAACACCTAAGAGTAAACCAAAACTTGGTTTATGAATCTGGCTCC
CTCAACTTTTCTAAACTTGAAATTCAATCACAAGTCGATTCCCAGCATGTGGGCCACAGT
GTTCTAACTGCTAAAGGCATGGCACTGTTTGGAGAAGGGAAGGCAGAGTTTACTGGGAGG
CATGATGCTCATTTAAATGGAAAGGTTATTGGAACTTTGAAAAATTCTCTTTTCTTTTCA
GCCCAGCCATTTGAGATCACGGCATCCACAAACAATGAAGGGAATTTGAAAGTTCGTTTT
CCATTAAGGTTAACAGGGAAGATAGACTTCCTGAATAACTATGCACTGTTTCTGAGTCCC
AGTGCCCAGCAAGCAAGTTGGCAAGTAAGTGCTAGGTTCAATCAGTATAAGTACAACCAA
AATTTCTCTGCTGGAAACAACGAGAACATTATGGAGGCCCATGTAGGAATAAATGGAGAA
GCAAATCTGGATTTCTTAAACATTCCTTTAACAATTCCTGAAATGCGTCTACCTTACACA
ATAATCACAACTCCTCCACTGAAAGATTTCTCTCTATGGGAAAAAACAGGCTTGAAGGAA
TTCTTGAAAACGACAAAGCAATCATTTGATTTAAGTGTAAAAGCTCAGTATAAGAAAAAC
AAACACAGGCATTCCATCACAAATCCTTTGGCTGTGCTTTGTGAGTTTATCAGTCAGAGC
ATCAAATCCTTTGACAGGCATTTTGAAAAAAACAGAAACAATGCATTAGATTTTGTCACC
AAATCCTATAATGAAACAAAAATTAAGTTTGATAAGTACAAAGCTGAAAAATCTCACGAC
GAGCTCCCCAGGACCTTTCAAATTCCTGGATACACTGTTCCAGTTGTCAATGTTGAAGTG
TCTCCATTCACCATAGAGATGTCGGCATTCGGCTATGTGTTCCCAAAAGCAGTCAGCATG
CCTAGTTTCTCCATCCTAGGTTCTGACGTCCGTGTGCCTTCATACACATTAATCCTGCCA
TCATTAGAGCTGCCAGTCCTTCATGTCCCTAGAAATCTCAAGCTTTCTCTTCCACATTTC
AAGGAATTGTGTACCATAAGCCATATTTTTATTCCTGCCATGGGCAATATTACCTATGAT
TTCTCCTTTAAATCAAGTGTCATCACACTGAATACCAATGCTGAACTTTTTAACCAGTCA
GATATTGTTGCTCATCTCCTTTCTTCATCTTCATCTGTCATTGATGCACTGCAGTACAAA
TTAGAGGGCACCACAAGATTGACAAGAAAAAGGGGATTGAAGTTAGCCACAGCTCTGTCT
CTGAGCAACAAATTTGTGGAGGGTAGTCATAACAGTACTGTGAGCTTAACCACGAAAAAT
ATGGAAGTGTCAGTGGCAAAAACCACAAAAGCCGAAATTCCAATTTTGAGAATGAATTTC
AAGCAAGAACTTAATGGAAATACCAAGTCAAAACCTACTGTCTCTTCCTCCATGGAATTT
AAGTATGATTTCAATTCTTCAATGCTGTACTCTACCGCTAAAGGAGCAGTTGACCACAAG
CTTAGCTTGGAAAGCCTCACCTCTTACTTTTCCATTGAGTCATCTACCAAAGGAGATGTC
AAGGGTTCGGTTCTTTCTCGGGAATATTCAGGAACTATTGCTAGTGAGGCCAACACTTAC
TTGAATTCCAAGAGCACACGGTCTTCAGTGAAGCTGCAGGGCACTTCCAAAATTGATGAT
ATCTGGAACCTTGAAGTAAAAGAAAATTTTGCTGGAGAAGCCACACTCCAACGCATATAT
TCCCTCTGGGAGCACAGTACGAAAAACCACTTACAGCTAGAGGGCCTCTTTTTCACCAAC
GGAGAACATACAAGCAAAGCCACCCTGGAACTCTCTCCATGGCAAATGTCAGCTCTTGTT
CAGGTCCATGCAAGTCAGCCCAGTTCCTTCCATGATTTCCCTGACCTTGGCCAGGAAGTG
GCCCTGAATGCTAACACTAAGAACCAGAAGATCAGATGGAAAAATGAAGTCCGGATTCAT
TCTGGGTCTTTCCAGAGCCAGGTCGAGCTTTCCAATGACCAAGAAAAGGCACACCTTGAC
ATTGCAGGATCCTTAGAAGGACACCTAAGGTTCCTCAAAAATATCATCCTACCAGTCTAT
GACAAGAGCTTATGGGATTTCCTAAAGCTGGATGTAACCACCAGCATTGGTAGGAGACAG
CATCTTCGTGTTTCAACTGCCTTTGTGTACACCAAAAACCCCAATGGCTATTCATTCTCC
ATCCCTGTAAAAGTTTTGGCTGATAAATTCATTACTCCTGGGCTGAAACTAAATGATCTA
AATTCAGTTCTTGTCATGCCTACGTTCCATGTCCCATTTACAGATCTTCAGGTTCCATCG
TGCAAACTTGACTTCAGAGAAATACAAATCTATAAGAAGCTGAGAACTTCATCATTTGCC
CTCAACCTACCAACACTCCCCGAGGTAAAATTCCCTGAAGTTGATGTGTTAACAAAATAT
TCTCAACCAGAAGACTCCTTGATTCCCTTTTTTGAGATAACCGTGCCTGAATCTCAGTTA
ACTGTGTCCCAGTTCACGCTTCCAAAAAGTGTTTCAGATGGCATTGCTGCTTTGGATCTA
AATGCAGTAGCCAACAAGATCGCAGACTTTGAGTTGCCCACCATCATCGTGCCTGAGCAG
ACCATTGAGATTCCCTCCATTAAGTTCTCTGTACCTGCTGGAATTGTCATTCCTTCCTTT
CAAGCACTGACTGCACGCTTTGAGGTAGACTCTCCCGTGTATAATGCCACTTGGAGTGCC
AGTTTGAAAAACAAAGCAGATTATGTTGAAACAGTCCTGGATTCCACATGCAGCTCAACC
GTACAGTTCCTAGAATATGAACTAAATGTTTTGGGAACACACAAAATCGAAGATGGTACG
TTAGCCTCTAAGACTAAAGGAACACTTGCACACCGTGACTTCAGTGCAGAATATGAAGAA
GATGGCAAATTTGAAGGACTTCAGGAATGGGAAGGAAAAGCGCACCTCAATATCAAAAGC
CCAGCGTTCACCGATCTCCATCTGCGCTACCAGAAAGACAAGAAAGGCATCTCCACCTCA
GCAGCCTCCCCAGCCGTAGGCACCGTGGGCATGGATATGGATGAAGATGACGACTTTTCT
AAATGGAACTTCTACTACAGCCCTCAGTCCTCTCCAGATAAAAAACTCACCATATTCAAA
ACTGAGTTGAGGGTCCGGGAATCTGATGAGGAAACTCAGATCAAAGTTAATTGGGAAGAA
GAGGCAGCTTCTGGCTTGCTAACCTCTCTGAAAGACAACGTGCCCAAGGCCACAGGGGTC
CTTTATGATTATGTCAACAAGTACCACTGGGAACACACAGGGCTCACCCTGAGAGAAGTG
TCTTCAAAGCTGAGAAGAAATCTGCAGAACAATGCTGAGTGGGTTTATCAAGGGGCCATT
AGGCAAATTGATGATATCGACGTGAGGTTCCAGAAAGCAGCCAGTGGCACCACTGGGACC
TACCAAGAGTGGAAGGACAAGGCCCAGAATCTGTACCAGGAACTGTTGACTCAGGAAGGC
CAAGCCAGTTTCCAGGGACTCAAGGATAACGTGTTTGATGGCTTGGTACGAGTTACTCAA
AAATTCCATATGAAAGTCAAGCATCTGATTGACTCACTCATTGATTTTCTGAACTTCCCC
AGATTCCAGTTTCCGGGGAAACCTGGGATATACACTAGGGAGGAACTTTGCACTATGTTC
ATAAGGGAGGTAGGGACGGTACTGTCCCAGGTATATTCGAAAGTCCATAATGGTTCAGAA
ATACTGTTTTCCTATTTCCAAGACCTAGTGATTACACTTCCTTTCGAGTTAAGGAAACAT
AAACTAATAGATGTAATCTCGATGTATAGGGAACTGTTGAAAGATTTATCAAAAGAAGCC
CAAGAGGTATTTAAAGCCATTCAGTCTCTCAAGACCACAGAGGTGCTACGTAATCTTCAG
GACCTTTTACAATTCATTTTCCAACTAATAGAAGATAACATTAAACAGCTGAAAGAGATG
AAATTTACTTATCTTATTAATTATATCCAAGATGAGATCAACACAATCTTCAATGATTAT
ATCCCATATGTTTTTAAATTGTTGAAAGAAAACCTATGCCTTAATCTTCATAAGTTCAAT
GAATTTATTCAAAACGAGCTTCAGGAAGCTTCTCAAGAGTTACAGCAGATCCATCAATAC
ATTATGGCCCTTCGTGAAGAATATTTTGATCCAAGTATAGTTGGCTGGACAGTGAAATAT
TATGAACTTGAAGAAAAGATAGTCAGTCTGATCAAGAACCTGTTAGTTGCTCTTAAGGAC
TTCCATTCTGAATATATTGTCAGTGCCTCTAACTTTACTTCCCAACTCTCAAGTCAAGTT
GAGCAATTTCTGCACAGAAATATTCAGGAATATCTTAGCATCCTTACCGATCCAGATGGA
AAAGGGAAAGAGAAGATTGCAGAGCTTTCTGCCACTGCTCAGGAAATAATTAAAAGCCAG
GCCATTGCGACGAAGAAAATAATTTCTGATTACCACCAGCAGTTTAGATATAAACTGCAA
GATTTTTCAGACCAACTCTCTGATTACTATGAAAAATTTATTGCTGAATCCAAAAGATTG
ATTGACCTGTCCATTCAAAACTACCACACATTTCTGATATACATCACGGAGTTACTGAAA
AAGCTGCAATCAACCACAGTCATGAACCCCTACATGAAGCTTGCTCCAGGAGAACTTACT
ATCATCCTCTAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
X04506

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_2_Locus:
2p24-p23

# Macromolecular_Interacting_Partner_2_SNPs:
rs1367117; rs1801699; rs12713681; rs2163204; rs12713844; rs676210; rs1801703; rs12713675; rs1042034; rs12713843; rs6752026; rs12720854; rs679899; rs12713450; rs12720855; rs533617; rs12714192; rs1801695; rs12714214; rs12713559; rs12720843; rs1801701; rs1801702; rs12691202; rs1042031; rs12713540; rs12720801; rs9282603; rs584542; rs12714097; rs12720848; rs12714225; rs13306187; rs1041968; rs12720852; rs6413458; rs12720847; rs12713558; rs12713554; rs12713600; rs12713457; rs1801700; rs693; rs1799812; rs1041952; rs13306196; rs12720850; rs12713501; rs12720763; rs1800480; rs531819; rs673548; rs10205849; rs2678379; rs520354; rs12720825; rs12713771; rs12720773; rs12720781; rs12714034; rs12713911; rs3749054; rs10208524; rs12720796; rs12720832; rs12720774; rs11676704; rs579826; rs570877; rs3791980; rs12720841; rs6719207; rs661665; rs3791981; rs1800479; rs11901649; rs12720821; rs12720798; rs12714226; rs12713998; rs12714233; rs1800478; rs12720842; rs11126598; rs12720791; rs2854725; rs550619; rs12720770; rs11680233; rs12720771; rs12720813; rs12720833; rs12713799; rs12720797; rs12720812; rs1469513; rs12720844; rs12720828; rs12720795; rs12720803; rs3828293; rs12691188; rs12720851; rs10701091; rs12720783; rs12720794; rs12720808; rs12713908; rs12720826; rs12720768; rs12720782; rs12720800; rs12714221; rs12720814; rs12720762; rs12720849; rs497166; rs12720805; rs11902466; rs12720802; rs12720785; rs12714252; rs12720836; rs12714102; rs12714224; rs12720792; rs9282605; rs12720834; rs12720840; rs12720853; rs12720845; rs12720829; rs12720822; rs12720807; rs12720788; rs12720778; rs12713523; rs12720838; rs12720804; rs12713917; rs12720787; rs12714254; rs12720799; rs12713997; rs12720823; rs12714189; rs12720827; rs12720765; rs12713956; rs12714245; rs6729524; rs10199768; rs12720820; rs12713870; rs597331; rs12720789; rs12714264; rs12720839; rs12720772; rs12720810; rs12720779; rs12720793; rs12713868; rs12720767; rs12720815; rs488329; rs768226; rs12720811; rs12720764; rs12720817; rs12720758; rs12720759; rs9282604; rs12720786; rs12720769; rs12720816; rs13306197; rs768227; rs12714239; rs12720846; rs12720835; rs12714269; rs12713869; rs12720761; rs12714268; rs12714215; rs12713776; rs12720830; rs12720790; rs6727706; rs12714216; rs12720818; rs12720777; rs12714222; rs12714238; rs12713871; rs12720780; rs12714248; rs12714247; rs12720766; rs12720819; rs12720831; rs617314; rs1800481; rs512535; rs934197; rs6547925; rs12713429; rs11883541; rs9282606; rs9282608; rs9282607; rs11687484; rs1041971; rs1042021; rs1042013; rs4362589; rs1801696; rs35708286; rs1800476; rs13306194; rs41288783; rs13306206; rs1042027; rs1126468; rs1801694; rs535237; rs1041960; rs13306191; rs1042025; rs5742904; rs568413; rs13306190; rs1042022; rs13306198; rs1864423; rs13306204; rs1801698; rs1042023; rs1801697; rs1041956; rs1041962; rs13306192; rs13306195; rs1042006; rs13306188; rs13306200; rs1041974; rs13306203; rs13306193; rs2854726; rs10595692; rs34920068; rs552428; rs7589300; rs1054527; rs13306202; rs1367116; rs2000998; rs11440527; rs34519317; rs3762565; rs6413457; rs34607237; rs41291161; rs34102309; rs35442885; rs562956; rs13306205; rs2678378; rs35493179; rs9808029; rs34914206; rs41406449; rs2000997; rs11689972; rs13003321; rs35313978; rs13005150; rs35911751; rs35377456; rs3762564; rs35046475; rs34092033; rs13306201; rs34194949; rs34594011; rs1625714; rs10635819; rs35239349; rs1625764; rs34557689; rs13306199; rs34469176; rs1560357; rs35068532; rs35621726; rs10184191; rs10197075; rs11889738; rs11891086; rs11892073; rs11893021; rs12467932; rs12468735; rs13392272; rs1713222; rs1713223; rs17398765; rs34722314; rs34776010; rs4327259; rs4371387; rs547186; rs585967; rs588245; rs589566; rs6725189; rs6756501; rs7575840; rs952274; rs952275

# Macromolecular_Interacting_Partner_2_General_References:
3763409; 3652907; 3759943; 3464946; 3030729; 3461454; 3513177; 2115173; 3001697; 3860836; 6373369; 2567736; 2883086; 3676265; 3841204; 3621347; 2450346; 3426612; 2445342; 3903660; 2994225; 2932736; 3841481; 3024665; 3659919; 3773997; 3087360; 10679026; 1979313; 2563166; 2216805; 7883971; 8889592; 9259199; 9490296; 12551903

# Macromolecular_Interacting_Partner_2_References:
10833526; 11072063; 11870221; 15496550

# Macromolecular_Interacting_Partner_3_ID:
5231

# Macromolecular_Interacting_Partner_3_Name:
UMP-CMP kinase

# Macromolecular_Interacting_Partner_3_Synonyms:
Cytidylate kinase; Deoxycytidylate kinase; Cytidine monophosphate kinase; Uridine monophosphate/cytidine monophosphate kinase; UMP/CMP kinase; UMP/CMPK; Uridine monophosphate kinase

# Macromolecular_Interacting_Partner_3_Gene_Name:
CMPK

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>
UMPCMP kinaseMKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDS
QYGELIEKYIKEGKIVPVEITISLLKREMDQTMAANAQKNKFLIDGFPRNQDNLQGWNKT
MDGKADVSFVLFFDCNNEICIERCLERGKSSGRSDDNRESLEKRIQTYLQSTKPIIDLYE
EMGKVKKIDASKSVDEVFDEVVQIFDKEG

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
196

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
22223

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
5.20

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleotide kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Nucleotide transport and metabolism 

# Macromolecular_Interacting_Partner_3_Specific_Function:
Catalyzes specific phosphoryl transfer from ATP to UMP and CMP

# Macromolecular_Interacting_Partner_3_Pathway:
map00240  Pyrimidine metabolism

# Macromolecular_Interacting_Partner_3_Reaction:
ATP + (d)CMP = ADP + (d)CDP

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00406:ADK

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
EC 2.7.4.14

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
6578133

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
KCY_HUMAN (P30085)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
CMPK

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
CMPK

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:18170

# Macromolecular_Interacting_Partner_3_PDB_ID:
1TEV

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Nucleus. Cytoplasm. Note=Mainly nuclear

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>687 bp
ATGCTGAGCCGCTGCCGCAGCGGGCTGCTCCACGTCCTGGGCCTTAGCTTCCTGCTGCAG
ACCCGCCGGCCGATTCTCCTCTGCTCTCCACGTCTCATGAAGCCGCTGGTCGTGTTCGTC
CTCGGCGGCCCCGGCGCCGGCAAGGGGACCCAGTGCGCCCGCATCGTCGAGAAATATGGC
TACACACACCTTTCTGCAGGAGAGCTGCTTCGTGATGAAAGGAAGAACCCAGATTCACAG
TATGGTGAACTTATTGAAAAGTACATTAAAGAAGGAAAGATTGTACCAGTTGAGATAACC
ATCAGTTTATTAAAGAGGGAAATGGATCAGACAATGGCTGCCAATGCTCAGAAGAATAAA
TTCTTGATTGATGGGTTTCCAAGAAATCAAGACAACCTTCAAGGATGGAACAAGACCATG
GATGGGAAGGCAGATGTATCTTTCGTTCTCTTTTTTGACTGTAATAATGAGATTTGTATT
GAACGATGTCTTGAGAGGGGAAAGAGTAGTGGTAGGAGTGATGACAACAGAGAGAGCTTG
GAAAAGAGAATTCAGACCTACCTTCAGTCAACAAAGCCAATTATTGACTTATATGAAGAA
ATGGGGAAAGTCAAGAAAATAGATGCTTCTAAATCTGTTGATGAAGTTTTTGATGAAGTT
GTGCAGATTTTTGACAAGGAAGGCTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF070416

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_3_Locus:
1p32

# Macromolecular_Interacting_Partner_3_SNPs:
rs35687416; rs6656779; rs1044457; rs3088062; rs6795; rs3125648; rs2820981; rs17103161; rs2622925; rs10789507; rs12718447; rs10890478; rs2622903; rs2820989; rs6660321; rs4492666; rs4926836; rs10890477; rs11211523; rs3122620; rs4926840; rs4926824; rs11802287; rs12123269; rs12132521; rs7534328; rs12117686; rs12749507; rs6659946; rs11211521; rs9436882; rs11211524; rs2245850; rs11584518; rs2820986; rs11211520; rs2820994; rs11582877; rs2306470; rs12090346; rs9436883; rs2250183; rs12068451; rs3122621; rs4926839; rs2622902; rs2622908; rs12081190; rs2253511; rs4926838; rs12087353; rs4926544; rs11211518; rs11211522; rs2622918; rs2820984; rs12562561; rs12083822; rs2622911; rs3125639; rs2622914; rs12566521; rs2622901; rs11579854; rs3125646; rs6698471; rs7541522; rs6588365; rs6698717; rs2246707; rs3122623; rs7532785; rs2622913; rs3122622; rs12567687; rs3925058; rs9988633; rs11211517; rs7543016; rs11554567; rs3835608; rs10198; rs2820990; rs10639560; rs28797184; rs11368245; rs10623948; rs6684213; rs6681868; rs13375896; rs34192192; rs2246708; rs35072721; rs2622912; rs35234940; rs6696620; rs4600090; rs28461889; rs34536867; rs12031563; rs10713246; rs35624696; rs5773945; rs11379501; rs12127982; rs3122610; rs2622924; rs35175280; rs2820993; rs28752184; rs34677520; rs11578038; rs35560035; rs11444039; rs7529388; rs12030848; rs3125643; rs34979288; rs35068095; rs3125640; rs35880845; rs12048407; rs3125647; rs12130328; rs3046950; rs12024163; rs7549484; rs12121831; rs35915510; rs12077141; rs10789506; rs2622906; rs12086199; rs34928345; rs34856862; rs11211525; rs4528158; rs7550999; rs35201142; rs36038736; rs28871045; rs12076263; rs3122609; rs12079592; rs7525552; rs10157734; rs4926832; rs2622904; rs2820987; rs12134888; rs6668250; rs10717198; rs12039270; rs34727473; rs7549485; rs3835609; rs11286214; rs4319382; rs3125642; rs10649132; rs34347262; rs12031601; rs2622907; rs34592236; rs2820988; rs12757893; rs12746766; rs12129259; rs6657172; rs34324996; rs11353905; rs34374399; rs35057132; rs34952704; rs35124142; rs11334963; rs12026822; rs12136812; rs2405918; rs3214951; rs34419291; rs34326568; rs34658109; rs34739143; rs35595628; rs10666791; rs2622905; rs12135037; rs11584578; rs28819073; rs3125645; rs12097707; rs10604027; rs12760270; rs12760379; rs11211516; rs11211526; rs12039726; rs12061831; rs12081669; rs12126139; rs12731806; rs12732050; rs17103165; rs17103168; rs17103179; rs17370337; rs17370386; rs17452995; rs2406105; rs2622923; rs2820980; rs3122618; rs3125635; rs3814003; rs6662189; rs6690084; rs7530285; rs7534571; rs9436874

# Macromolecular_Interacting_Partner_3_General_References:
10931946; 8313870; 1286669

# Macromolecular_Interacting_Partner_3_References:
15130468

# Macromolecular_Interacting_Partner_4_ID:
7217

# Macromolecular_Interacting_Partner_4_Name:
C->U-editing enzyme APOBEC-1

# Macromolecular_Interacting_Partner_4_Synonyms:
Apolipoprotein B mRNA- editing enzyme 1; HEPR

# Macromolecular_Interacting_Partner_4_Gene_Name:
APOBEC1

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>C>Uediting enzyme 
APOBEC1MTSEKGPSTGDPTLRRRIEPWEFDVFYDPRELRKEACLLYEIKWGMSRKIWRS
SGKNTTNHVEVNFIKKFTSERDFHPSMSCSITWFLSWSPCWECSQAIREFLSRHPGVTLV
IYVARLFWHMDQQNRQGLRDLVNSGVTIQIMRASEYYHCWRNFVNYPPGDEAHWPQYPPL
WMMLYALELHCIILSLPPCLKISRRWQNHLTFFRLHLQNCHYQTIPPHILLATGLIHPSV
AWR

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
236

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
28192

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.90

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF05240:APOBEC_C;
PF08210:APOBEC_N

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
1177798

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
ABEC1_HUMAN (P41238)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
APOBEC1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
APOBEC1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:604

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>711 bp
ATGACTTCTGAGAAAGGTCCTTCAACCGGTGACCCCACTCTGAGGAGAAGAATCGAACCC
TGGGAGTTTGACGTCTTCTATGACCCCAGAGAACTTCGTAAAGAGGCCTGTCTGCTCTAC
GAAATCAAGTGGGGCATGAGCCGGAAGATCTGGCGAAGCTCAGGCAAAAACACCACCAAT
CACGTGGAAGTTAATTTTATAAAAAAATTTACGTCAGAAAGAGATTTTCACCCATCCATC
AGCTGCTCCATCACCTGGTTCTTGTCCTGGAGTCCCTGCTGGGAATGCTCCCAGGCTATT
AGAGAGTTTCTGAGTCGGCACCCTGGTGTGACTCTAGTGATCTACGTAGCTCGGCTTTTT
TGGCACATGGATCAACAAAATCGGCAAGGTCTCAGGGACCTTGTTAACAGTGGAGTAACT
ATTCAGATTATGAGAGCATCAGAGTATTATCACTGCTGGAGGAATTTTGTCAACTACCCA
CCTGGGGATGAAGCTCACTGGCCACAATACCCACCTCTGTGGATGATGTTGTACGCACTG
GAGCTGCACTGCATAATTCTAAGTCTTCCACCCTGTTTAAAGATTTCAAGAAGATGGCAA
AATCATCTTACATTTTTCAGACTTCATCTTCAAAACTGCCATTACCAAACGATTCCGCCA
CACATCCTTTTAGCTACAGGGCTGATACATCCTTCTGTGGCTTGGAGATGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
L25877

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_4_Locus:
12p13.1

# Macromolecular_Interacting_Partner_4_SNPs:
rs2302515; rs10431309; rs11055022; rs10431308; rs7973596; rs1860979; rs10772596; rs2080127; rs7294364; rs7316755; rs1015102; rs10845624; rs9651863; rs9645733; rs11055090; rs7137790; rs11838031; rs1860980; rs12422951; rs7961135; rs9795639; rs10845640; rs10845645; rs11832654; rs11055095; rs1035074; rs12228353; rs10845634; rs9651861; rs6488547; rs11611063; rs10845642; rs11055029; rs10431307; rs10845657; rs7970073; rs7975771; rs7969976; rs7310952; rs7976005; rs1806839; rs7958776; rs12820011; rs34275479; rs3040825; rs12825156; rs35728819; rs34404451; rs5796284; rs34998188; rs35969738; rs11055088; rs33949127; rs12314594; rs12312962; rs34345616; rs12372347; rs11055072; rs5796285; rs11055081; rs11055100; rs35381656; rs34193971; rs12314233; rs3214348; rs35376134; rs34720792; rs36221958; rs34124287; rs34455959; rs12297895; rs9645753; rs35561148; rs11055089; rs7305040; rs35684921; rs35741011; rs12810441; rs35834174; rs5796283; rs6144603; rs12397501; rs35080986; rs5796282; rs12310172; rs7295565; rs11055101; rs12301368; rs12309237; rs9651862; rs35853455; rs4883423; rs12829438; rs4272856; rs12319123; rs35417928; rs7964709; rs28706911; rs11055118; rs10734858; rs10772577; rs10845677; rs11055005; rs11055006; rs11055010; rs11055012; rs11055144; rs12318317; rs12366850; rs2110221; rs2377084; rs6488567; rs7963536; rs7968271; rs7979153

# Macromolecular_Interacting_Partner_4_General_References:
8208612; 8078915; 9186903; 9479499; 8999813; 10781591; 10669759; 11727199

# Macromolecular_Interacting_Partner_4_References:
11863358; 11870221; 15496550

# Macromolecular_Interacting_Partner_5_ID:
8376

# Macromolecular_Interacting_Partner_5_Name:
BK150C2.4 protein

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
bK150C2.4

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>BK150C2.4 protein
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPRLDAKIFRGQVPR
SFIRAPFQVLSSPFGQCAPPHGTAQVQWPPQLTAGREQGRP

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
101

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
11823

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
11.65

# Macromolecular_Interacting_Partner_5_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF08210:APOBEC_N

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
47678321

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
Q6ICH3_HUMAN (Q6ICH3)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
bK150C2.4

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
bK150C2.4

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:17356

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>306 bp
ATGAAGCCTCACTTCAGAAACACAGTGGAGCGAATGTATCGAGACACATTCTCCTACAAC
TTTTATAATAGACCCATCCTTTCTCGTCGGAATACCGTCTGGCTGTGCTACGAAGTGAAA
ACAAAGGGTCCCTCAAGGCCCCGTTTGGACGCAAAGATCTTTCGAGGCCAGGTGCCCAGG
TCTTTCATCAGAGCCCCATTTCAAGTGCTCAGTAGCCCCTTTGGCCAGTGCGCCCCACCA
CATGGGACAGCGCAGGTCCAGTGGCCTCCCCAGCTGACCGCAGGCAGGGAACAAGGCAGA
CCCTAG

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
CR456395

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Locus:
Not Available

# Macromolecular_Interacting_Partner_5_SNPs:
Not Available

# Macromolecular_Interacting_Partner_5_General_References:
Not Available

# Macromolecular_Interacting_Partner_5_References:
15721369; 16201018; 16963778; 17121840

# Macromolecular_Interacting_Partner_6_ID:
8075

# Macromolecular_Interacting_Partner_6_Name:
Uridine-cytidine kinase 2

# Macromolecular_Interacting_Partner_6_Synonyms:
UCK 2; Uridine monophosphokinase 2; Cytidine monophosphokinase 2

# Macromolecular_Interacting_Partner_6_Gene_Name:
UCK2

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Uridinecytidine kinase 2
MAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKSSVCAKIVQLLGQNEVDYRQKQVVILS
QDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSRK
EETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQ
ILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDILNGGPSKRQTNG
CLNGYTPSRKRQASESSSRPH

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
261

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
29299

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
6.68

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleoside kinase activity
Function:  uridine kinase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Nucleotide transport and metabolism 

# Macromolecular_Interacting_Partner_6_Specific_Function:
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, 4-N-acetylcytidine, 4-N- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and 4-N-anisoylcytidine

# Macromolecular_Interacting_Partner_6_Pathway:
map00240  Pyrimidine metabolism

# Macromolecular_Interacting_Partner_6_Reaction:
ATP + uridine = ADP + UMP

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00485:PRK

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
EC 2.7.1.48

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
1655420

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
UCK2_HUMAN (Q9BZX2)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
UCK2

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
UCK2

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:12562

# Macromolecular_Interacting_Partner_6_PDB_ID:
1XRJ

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>336 bp
ATGAAGCTTTTTGTGGATACAGATGCGGACACCCGGCTCTCACGCAGAGTATTAAGGGAC
ATCAGCGAGAGAGGCAGGGATCTTGAGCAGATTTTATCTCAGTACATTACGTTCGTCAAG
CCTGCCTTTGAGGAATTCTGCTTGCCAACAAAGCAGTATGCTGATGTGATCATCCCTAGA
GGTGCAGATAATCTGGTGGCCATCAACCTCATCGAGCAGCACATCCAGGACATCCTGAAT
GGAGGGCCCTCCAAACGGCAGACCAATGGCTGTCTCAACGGCTACACCCCTTCACGCAAG
AGGCAGGCATCGGAGTCCAGCAGCAGGCCGCATTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
D78335

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_6_Locus:
1q23

# Macromolecular_Interacting_Partner_6_SNPs:
rs2185268; rs2348837; rs473222; rs495529; rs6426942; rs7517175; rs6678380; rs10800164; rs10753694; rs3790669; rs10800161; rs10918293; rs12562047; rs4656467; rs4657486; rs6426941; rs4535982; rs6684773; rs2241965; rs7543127; rs4548416; rs3762365; rs7549754; rs10800162; rs6684730; rs3790670; rs10918291; rs2225980; rs12569109; rs10918295; rs3790674; rs4657482; rs6686237; rs1061771; rs3790668; rs4657481; rs6703280; rs3790665; rs4657488; rs10918307; rs6702462; rs12080800; rs16852248; rs16851987; rs12066877; rs6693108; rs6681761; rs12090859; rs7519919; rs11579300; rs11585115; rs16852373; rs7520107; rs3790672; rs6703209; rs3790673; rs2814472; rs10918309; rs10494448; rs10918297; rs7533364; rs6677965; rs12125493; rs7539793; rs6687465; rs9887956; rs3790655; rs4483381; rs16851292; rs12084653; rs4657487; rs7547020; rs11590711; rs12566281; rs3790654; rs3806333; rs16851444; rs3790659; rs946542; rs485338; rs10800165; rs1061772; rs7527008; rs12041574; rs10800160; rs16851949; rs10737520; rs4657489; rs477033; rs3790658; rs12060526; rs3790664; rs2349108; rs4657490; rs1663837; rs1934275; rs10918304; rs7547622; rs12119053; rs7532050; rs7539819; rs4657484; rs7535442; rs12565188; rs12045367; rs6682894; rs7535554; rs12239084; rs3790663; rs7544934; rs3790666; rs3790657; rs872178; rs16851240; rs12138699; rs16852574; rs7547320; rs10753693; rs16851839; rs4657485; rs10918303; rs7527146; rs10918294; rs16852447; rs12075898; rs3790656; rs10918300; rs7535484; rs4657478; rs10753692; rs16852621; rs4657483; rs7523147; rs7522654; rs3790667; rs10918298; rs4656465; rs6682285; rs6690966; rs3790661; rs16851843; rs10918301; rs10918299; rs3790671; rs7535966; rs12401468; rs7522968; rs6666697; rs3790660; rs4656466; rs2275432; rs10753696; rs4145763; rs3748699; rs7534738; rs536109; rs36009659; rs11553301; rs1803412; rs36109644; rs10918308; rs6660813; rs12745373; rs34532446; rs6663402; rs12072837; rs12121204; rs34140033; rs41268528; rs12092719; rs7546122; rs6686485; rs7416265; rs34252102; rs35804765; rs11454411; rs3806332; rs12739071; rs11586298; rs2814465; rs35813521; rs10577957; rs34043008; rs3077616; rs34440554; rs4518878; rs12409320; rs6682243; rs34784270; rs7535552; rs10918302; rs12080667; rs7536051; rs10737519; rs10753697; rs34641175; rs34916926; rs35249921; rs35604519; rs16851674; rs35963327; rs10800163; rs36121196; rs2349109; rs35429852; rs10571444; rs12085462; rs35032034; rs10537610; rs4656464; rs3838418; rs12146084; rs529859; rs35567047; rs6666086; rs10918305; rs3806331; rs6686824; rs35381555; rs12122202; rs11296145; rs28480651; rs12087157; rs34075600; rs10918306; rs6703425; rs5778473; rs12133153; rs35978371; rs11809157; rs12129866; rs11801732; rs12754456; rs1344179; rs28668922; rs11351119; rs35427252; rs7534635; rs12041629; rs28821193; rs12410853; rs4657479; rs546390; rs34800847; rs10159235; rs3790662; rs34162295; rs2275433; rs12058054; rs11312474; rs12091018; rs34396586; rs10569937; rs12118784; rs12750131; rs34638867; rs10918292; rs35204231; rs12080047; rs7518418; rs34877436; rs12122132; rs34130134; rs34548887; rs6661905; rs34873145; rs6681589; rs12403805; rs34338305; rs12410219; rs1768903; rs10573572; rs509515; rs12122204; rs12079614; rs11336105; rs10918296; rs35109366; rs12122208; rs11410048; rs4431823; rs28513696; rs10753695; rs34109502; rs36046806; rs10494449; rs10494450; rs10800159; rs1132125; rs12030221; rs12067209; rs12095265; rs12095402; rs12118019; rs16852868; rs2153263; rs2153264; rs3180503; rs35899976; rs3748700; rs3748701; rs480049; rs480050; rs480813; rs506813; rs512542; rs514163; rs520858; rs526374; rs544617; rs577133; rs6684584; rs7556417

# Macromolecular_Interacting_Partner_6_General_References:
8812458; 11306702; 11494055

# Macromolecular_Interacting_Partner_6_References:
11027694

# Macromolecular_Interacting_Partner_7_ID:
7788

# Macromolecular_Interacting_Partner_7_Name:
DNA dC->dU-editing enzyme APOBEC-3G

# Macromolecular_Interacting_Partner_7_Synonyms:
APOBEC-related cytidine deaminase; ARCD; APOBEC-related protein; ARP-9; CEM15; CEM-15

# Macromolecular_Interacting_Partner_7_Gene_Name:
APOBEC3G

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>DNA dC>dUediting enzyme 
APOBEC3GMKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAK
IFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDP
KVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELF
EPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTW
VLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCA
QEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVD
HQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
384

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
46408

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
8.06

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
DNA deaminase (cytidine deaminase) that mediates a form of innate resistance to retroviral infections (at least to HIV-1 infection) by triggering G-to-A hypermutation in the newly synthesized viral DNA. The replacements C-to-U in the minus strand DNA of HIV-1 during reverse transcription, leads to G-to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations. Modification of both DNA strands is not excluded. This antiviral activity is neutralized by the virion infectivity factor (VIF), that prevents the incorporation of APOBEC3G into progeny HIV-1 virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome. APOBEC3G binds a variety of RNAs, but does not display detectable APOB, NF1 and NAT1 mRNA editing

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF05240:APOBEC_C;
PF08210:APOBEC_N

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
10197640

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
ABC3G_HUMAN (Q9HC16)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
APOBEC3G

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
APOBEC3G

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:17357

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Cytoplasm. Nucleus. Note=Mainly cytoplasmic. Small amount are found in the nucleus. During HIV-1 infection, virion-encapsidated in absence of HIV-1 VIF

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1155 bp
ATGAAGCCTCACTTCAGAAACACAGTGGAGCGAATGTATCGAGACACATTCTCCTACAAC
TTTTATAATAGACCCATCCTTTCTCGTCGGAATACCGTCTGGCTGTGCTACGAAGTGAAA
ACAAAGGGTCCCTCAAGGCCCCCTTTGGACGCAAAGATCTTTCGAGGCCAGGTGTATTCC
GAACTTAAGTACCACCCAGAGATGAGATTCTTCCACTGGTTCAGCAAGTGGAGGAAGCTG
CATCGTGACCAGGAGTATGAGGTCACCTGGTACATATCCTGGAGCCCCTGCACAAAGTGT
ACAAGGGATATGGCCACGTTCCTGGCCGAGGACCCGAAGGTTACCCTGACCATCTTCGTT
GCCCGCCTCTACTACTTCTGGGACCCAGATTACCAGGAGGCGCTTCGCAGCCTGTGTCAG
AAAAGAGACGGTCCGCGTGCCACCATGAAGATCATGAATTATGACGAATTTCAGCACTGT
TGGAGCAAGTTCGTGTACAGCCAAAGAGAGCTATTTGAGCCTTGGAATAATCTGCCTAAA
TATTATATATTACTGCACATCATGCTGGGGGAGATTCTCAGACACTCGATGGATCCACCC
ACATTCACTTTCAACTTTAACAATGAACCTTGGGTCAGAGGACGGCATGAGACTTACCTG
TGTTATGAGGTGGAGCGCATGCACAATGACACCTGGGTCCTGCTGAACCAGCGCAGGGGC
TTTCTATGCAACCAGGCTCCACATAAACACGGTTTCCTTGAAGGCCGCCATGCAGAGCTG
TGCTTCCTGGACGTGATTCCCTTTTGGAAGCTGGACCTGGACCAGGACTACAGGGTTACC
TGCTTCACCTCCTGGAGCCCCTGCTTCAGCTGTGCCCAGGAAATGGCTAAATTCATTTCA
AAAAACAAACACGTGAGCCTGTGCATCTTCACTGCCCGCATCTATGATGATCAAGGAAGA
TGTCAGGAGGGGCTGCGCACCCTGGCCGAGGCTGGGGCCAAAATTTCAATAATGACATAC
AGTGAATTTAAGCACTGCTGGGACACCTTTGTGGACCACCAGGGATGTCCCTTCCAGCCC
TGGGATGGACTAGATGAGCACAGCCAAGACCTGAGTGGGAGGCTGCGGGCCATTCTCCAG
AATCAGGAAAACTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
AF182420

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_7_Locus:
22q13.1-q13.2

# Macromolecular_Interacting_Partner_7_SNPs:
rs8177832; rs17496046; rs5757465; rs35941380; rs11545130; rs2413570; rs2899313; rs2011861; rs10427620; rs3091374; rs6001417; rs2413571; rs2011869; rs3736685; rs17537581; rs12158985; rs28537571; rs17496018; rs28534684; rs5757468; rs2294367; rs5757470; rs17496025; rs2413572; rs2294366; rs5757464; rs17537574; rs5757467; rs17496032; rs36083961; rs35585306; rs34300092; rs35260874; rs34737056; rs17537561; rs34949391; rs2294365; rs17537568; rs12158580; rs9607609; rs12160242; rs17537554; rs34819681; rs35954479; rs34242740; rs6001418; rs6519165; rs6001416; rs5757463; rs5750743; rs34550797; rs7291971; rs6519166; rs9622924; rs17000736; rs8177831; rs14888; rs35223997; rs5757471; rs34079083; rs36007289; rs35205117; rs5757466; rs34146529; rs35191768; rs6001419; rs17537588; rs34017706; rs12165511; rs36057744; rs13057460; rs6001422; rs35065198; rs35605671; rs28425624; rs28392969; rs34649639; rs34563939; rs35048535; rs9622923; rs35895710; rs6001420; rs34193985; rs7511134; rs12158619; rs28614110; rs34913053; rs17537548; rs35986055; rs34798692; rs17496039; rs10605628; rs9622921; rs8142124; rs17496004; rs5757462; rs8142214; rs34460050; rs34251862; rs12158029; rs36040712; rs11703289; rs11705514; rs12167454; rs139271; rs139272; rs139273; rs139274; rs139275; rs1569649; rs17000748; rs17000751; rs5757458; rs5995668; rs6001423; rs6001424; rs6001426; rs6001427; rs6001428; rs9611089

# Macromolecular_Interacting_Partner_7_General_References:
14557625; 10591208; 12859895

# Macromolecular_Interacting_Partner_7_References:
15210704; 15297452; 16201018

# Macromolecular_Interacting_Partner_8_ID:
8758

# Macromolecular_Interacting_Partner_8_Name:
Equilibrative nucleoside transporter 2

# Macromolecular_Interacting_Partner_8_Synonyms:
Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter; Equilibrative NBMPR-insensitive nucleoside transporter; Nucleoside transporter, ei-type; Solute carrier family 29 member 2; 36 kDa nucleolar protein HNP36; Hydrophobic nucleolar protein, 36 kDa; Delayed-early response protein 12

# Macromolecular_Interacting_Partner_8_Gene_Name:
SLC29A2

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Equilibrative nucleoside transporter 2
MARGDAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGNSTARILSTNHTG
PEDAFNFNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGSLLAILLLFALTAALVKVD
MSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLL
SMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQELETKAE
LLQSDENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLV
FTVTLSVFPAITAMVTSSTSPGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRL
LPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPR
QVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
456

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
50114

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
6.02

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
 Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_8_Signals:
1-24

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
13-33
70-90
99-119
124-144
162-182
193-213
291-311
324-344
360-380
386-406
432-452

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
2811137

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
S29A2_HUMAN (Q14542)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
SLC29A2

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
SLC29A2

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:11004

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Isoform 1:Cell membrane; multi-pass membrane protein. Isoform 2:Nucleus; nuclear membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1371 bp
ATGGCGCGAGGAGACGCCCCGCGGGACAGCTACCACCTGGTCGGGATCAGCTTCTTCATC
CTGGGGCTGGGCACCCTCCTTCCCTGGAACTTCTTCATCACCGCCATCCCGTACTTCCAG
GCGCGACTGGCCGGGGCCGGCAACAGCACAGCCAGGATCCTGAGCACCAACCACACGGGT
CCCGAGGATGCCTTCAACTTCAACAATTGGGTGACGCTGCTGTCCCAGCTGCCCCTGCTG
CTCTTCACCCTCCTCAACTCCTTCCTGTACCAGTGCGTCCCGGAGACGGTGCGCATTCTG
GGCAGCCTGCTGGCCATACTGCTGCTCTTTGCCCTGACAGCAGCGCTGGTCAAGGTGGAC
ATGAGCCCCGGACCCTTCTTCTCCATCACCATGGCCTCCGTCTGCTTCATCAACTCCTTC
AGTGCAGTCCTACAGGGCAGCCTCTTCGGGCAGCTGGGCACCATGCCCTCCACCTACAGC
ACCCTCTTCCTCAGCGGCCAGGGCCTGGCTGGGATCTTTGCTGCCCTTGCCATGCTCCTG
TCCATGGCCAGTGGCGTGGACGCCGAGACCTCTGCCCTGGGGTACTTTATCACGCCCTGT
GTGGGCATCCTCATGTCCATCGTGTGTTACCTGAGCCTGCCTCACCTGAAGTTTGCCCGC
TACTACCTGGCCAATAAATCATCCCAGGCCCAAGCTCAGGAGCTGGAGACCAAAGCTGAG
CTCCTCCAGTCTGATGAGAACGGGATTCCCAGTAGTCCCCAGAAAGTAGCTCTGACCCTG
GATCTTGACCTGGAGAAGGAGCCGGAATCAGAGCCAGATGAGCCCCAGAAGCCAGGAAAA
CCTTCAGTCTTCACTGTCTTCCAGAAGATCTGGCTGACAGCGCTGTGCCTTGTGTTGGTC
TTCACAGTCACCCTGTCCGTCTTCCCCGCCATCACAGCCATGGTGACCAGCTCCACCAGT
CCTGGGAAGTGGAGTCAGTTCTTCAACCCCATCTGCTGCTTCCTCCTCTTCAACATCATG
GACTGGCTGGGACGGAGCCTGACCTCTTACTTCCTGTGGCCAGACGAGGACAGCCGGCTG
CTGCCCCTGCTGGTCTGCCTGCGGTTCCTGTTCGTGCCCCTCTTCATGCTGTGCCACGTG
CCCCAGAGGTCCCGGCTGCCCATCCTCTTCCCACAGGATGCCTACTTCATCACCTTCATG
CTGCTCTTTGCCGTTTCTAATGGCTACCTGGTGTCCCTCACCATGTGCCTGGCGCCCAGG
CAGGTGCTGCCACACGAGAGGGAGGTGGCCGGCGCCCTCATGACCTTCTTCCTGGCCCTG
GGACTTTCCTGTGGAGCCTCCCTCTCCTTCCTCTTCAAGGCGCTGCTCTGA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
AF034102

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_8_Locus:
11q13

# Macromolecular_Interacting_Partner_8_SNPs:
rs8187661; rs1039593; rs3177514; rs4930358; rs7126064; rs2292123; rs2279861; rs2279862; rs7125100; rs7126018; rs12416747; rs1039594; rs10791872; rs8187658; rs3867130; rs12576299; rs1344410; rs12576293; rs12577196; rs4930178; rs4930359; rs12281049; rs4244813; rs7107191; rs7104297; rs17850744; rs17855425; rs12801227; rs34186490; rs34124904; rs11227466; rs4554890; rs3741366; rs10605893; rs11403442; rs7111197; rs10632640; rs35639157; rs35962792; rs7946434; rs33943132; rs34029417; rs1815807; rs35659701; rs7103571; rs35791794; rs10648232; rs11423263; rs34482391; rs1566871; rs11298226; rs12800796; rs35509820; rs11461356; rs35457397; rs1201452; rs1210071; rs34585457; rs12360603; rs1047029; rs10791871; rs12794121; rs34272485; rs7130857; rs8187644; rs8187646; rs8187647; rs8187657; rs8187659; rs8187660

# Macromolecular_Interacting_Partner_8_General_References:
9478986; 9396714; 7639753

# Macromolecular_Interacting_Partner_8_References:
Not Available

# Macromolecular_Interacting_Partner_9_ID:
8857

# Macromolecular_Interacting_Partner_9_Name:
Equilibrative nucleoside transporter 3

# Macromolecular_Interacting_Partner_9_Synonyms:
Solute carrier family 29 member 3

# Macromolecular_Interacting_Partner_9_Gene_Name:
SLC29A3

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Equilibrative nucleoside transporter 3
MAVVSEDDFQHSSNSTYRTTSSSLRADQEALLEKLLDRPPPGLQRPEDRFCGTYIIFFSL
GIGSLLPWNFFITAKEYWMFKLRNSSSPATGEDPEGSDILNYFESYLAVASTVPSMLCLV
ANFLLVNRVAVHIRVLASLTVILAIFMVITALVKVDTFSWTRGFFAVTIVCMVILSGAST
VFSSSIYGMTGSFPMRNSQALISGGAMGGTVSAVASLVDLAASSDVRNSALAFFLTATIF
LVLCMGLYLLLSRLEYARYYMRPVLAAHVFSGEEELPQDSLSAPSVASRFIDSHTPPLRP
ILKKTASLGFCVTYVFFITSLIYPAVCTNIESLNKGSGSLWTTKFFIPLTTFLLYNFADL
CGRQLTAWIQVPGPNSKALPGFVLLRTCLIPLFVLCNYQPRVHLKTVVFQSDVYPALLSS
LLGLSNGYLSTLALLYGPKIVPRELAEATGVVMSFYVCLGLTLGSACSTLLVHLI

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
475

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
51875

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
7.85

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
 Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter)

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_9_Signals:
Not Available

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
50-72
107-126
131-153
163-185
198-220
230-252
308-330
340-357
378-395
415-437
450-472

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
12656639

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
S29A3_HUMAN (Q9BZD2)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
SLC29A3

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
SLC29A3

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:23096

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>1428 bp
ATGGCCGTTGTCTCAGAGGACGACTTTCAGCACAGTTCAAACTCCACCTACAGAACCACA
AGCAGCAGTCTCCGAGCTGACCAGGAGGCACTGCTTGAGAAGCTGCTGGACCGCCCGCCC
CCTGGCCTGCAGAGGCCCGAGGACCGCTTCTGTGGCACATACATCATCTTCTTCAGCCTG
GGCATTGGCAGTCTACTGCCATGGAACTTCTTTATCACTGCCAAGGAGTACTGGATGTTC
AAACTCCGCAACTCCTCCAGCCCAGCCACCGGGGAGGACCCTGAGGGCTCAGACATCCTG
AACTACTTTGAGAGCTACCTTGCCGTTGCCTCCACCGTGCCCTCCATGCTGTGCCTGGTG
GCCAACTTCCTGCTTGTCAACAGGGTTGCAGTCCACATCCGTGTCCTGGCCTCACTGACG
GTCATCCTGGCCATCTTCATGGTGATAACTGCACTGGTGAAGGTGGACACTTTCTCCTGG
ACCCGTGGCTTTTTTGCGGTCACCATTGTCTGCATGGTGATCCTCAGCGGTGCCTCCACT
GTCTTCAGCAGCAGCATCTACGGCATGACCGGCTCCTTTCCTATGAGGAACTCCCAGGCA
CTGATATCAGGAGGAGCCATGGGCGGGACGGTCAGCGCCGTGGCCTCATTGGTGGACTTG
GCTGCATCCAGTGATGTGAGGAACAGCGCCCTGGCCTTCTTCCTGACGGCCACCATCTTC
CTCGTGCTCTGCATGGGACTCTACCTGCTGCTGTCCAGGCTGGAGTATGCCAGGTACTAC
ATGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGAAGAGGAGCTTCCCCAGGACTCC
CTCAGTGCCCCTTCGGTGGCCTCCAGATTCATTGATTCCCACACACCCCCTCTCCGCCCC
ATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGTCTTCTTCATCACCAGC
CTCATCTACCCCGCCGTCTGCACCAACATCGAGTCCCTCAACAAGGGCTCGGGCTCACTG
TGGACCACCAAGTTTTTCATCCCCCTCACTACCTTCCTCCTGTACAACTTTGCTGACCTA
TGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAATAGCAAGGCGCTCCCA
GGGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTTCGTGCTCTGTAACTACCAGCCC
CGCGTCCACCTGAAGACTGTGGTCTTCCAGTCCGATGTGTACCCCGCACTCCTCAGCTCC
CTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCTCTACGGGCCTAAGATT
GTGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGATGTCCTTTTATGTGTGCTTGGGC
TTAACACTGGGCTCAGCCTGCTCTACCCTCCTGGTGCACCTCATCTAG

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
AF326987

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_9_Locus:
10q22.1

# Macromolecular_Interacting_Partner_9_SNPs:
rs2487068; rs2252996; rs780668; rs2277257; rs999940; rs16928737; rs2252997; rs1084004; rs2275579; rs780680; rs780664; rs1538899; rs780660; rs780659; rs780666; rs703257; rs780654; rs946875; rs703256; rs2394793; rs7069807; rs1110399; rs780677; rs4600131; rs780675; rs2243460; rs780670; rs780676; rs6480510; rs2487067; rs6480511; rs809691; rs883764; rs7086724; rs12256138; rs2012500; rs780662; rs4494244; rs780672; rs780653; rs3781314; rs2249987; rs1538895; rs2066211; rs780655; rs10823723; rs1316421; rs11815656; rs3824770; rs7100381; rs2250002; rs6480513; rs12251921; rs12767108; rs16928705; rs10999773; rs10999778; rs1572810; rs7076329; rs6480514; rs780667; rs7090745; rs2249882; rs883763; rs780679; rs780674; rs7080325; rs3781316; rs2249989; rs780678; rs11812689; rs780669; rs2487066; rs2243496; rs7067629; rs10999776; rs7095417; rs11594628; rs780665; rs4430425; rs4348816; rs780661; rs3781311; rs3781313; rs2249753; rs10999770; rs7091983; rs884031; rs3781324; rs780658; rs10999775; rs7072838; rs780671; rs946973; rs10740374; rs12252326; rs3781310; rs10999771; rs3781309; rs3781312; rs1890885; rs2243540; rs3758570; rs3781317; rs2066209; rs780656; rs7900534; rs7083031; rs2066210; rs6480512; rs12220541; rs884681; rs3781327; rs16928722; rs7068179; rs7090777; rs12249513; rs10740375; rs7913673; rs780673; rs10999777; rs10999781; rs780657; rs7090611; rs884680; rs3781326; rs7086520; rs7071162; rs7071738; rs2249752; rs12252139; rs17525188; rs12252279; rs2243485; rs7071979; rs10999772; rs3781325; rs7087714; rs7084342; rs4747148; rs7924115; rs946979; rs780681; rs1572812; rs35065420; rs6650127; rs34069552; rs10716665; rs35206666; rs12263170; rs10625840; rs34905233; rs11376986; rs35919163; rs5786035; rs34110374; rs12356731; rs35335105; rs12269478; rs12243734; rs34152212; rs7913062; rs3059614; rs12762394; rs7911708; rs7914132; rs4746081; rs7094989; rs35701283; rs12267767; rs12220170; rs7068296; rs34294547; rs35368644; rs41281300; rs3781318; rs4641383; rs7916422; rs34315182; rs10999774; rs35720104; rs10999769; rs35239123; rs7077024; rs3837344; rs7913610; rs10552605; rs10999779; rs780663; rs35509882; rs3893272; rs3059612; rs35156362; rs1609652; rs35485497; rs34058912; rs12243650; rs4147262; rs7903407; rs35942216; rs12763826; rs3837345; rs34297699; rs34965758; rs3824768; rs34491538; rs41300554; rs36074226; rs7095479; rs7067937; rs11296364; rs35855172; rs7897272; rs34640546; rs3781315; rs34395748; rs12355187; rs12261581; rs10686987; rs12779065; rs10999783; rs36087675; rs12762772; rs5786034; rs10999782; rs34650529; rs34632350; rs10553895; rs34721394; rs12249991; rs11593088; rs3059610; rs28708771; rs35956296; rs10999768; rs28688626; rs35685893; rs10823722; rs10999766; rs10999784; rs10999785; rs10999786; rs10999788; rs11595617; rs11816935; rs12098507; rs12254223; rs12412201; rs12414898; rs1538898; rs1609651; rs17546494; rs2185416; rs2248674; rs34217506; rs35016944; rs35685474; rs7079524; rs780682; rs780683; rs780687; rs780688; rs780689; rs780690; rs780692; rs780693; rs780694; rs780695; rs780697; rs780698; rs7895122; rs7899555; rs869545; rs946879

# Macromolecular_Interacting_Partner_9_General_References:
11396612; 12384580; 12975309

# Macromolecular_Interacting_Partner_9_References:
Not Available

End of HMDB00089

Beginning of HMDB00092
# Accession_No:
HMDB00092

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-05-23 11:56:16

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Dimethylglycine

# Description:
Dimethylglycine (DMG) is an amino acid derivative found in the cells of all plants and animals and can be obtained in the diet in small amounts from grains and meat. The human body produces DMG when metabolizing choline into Glycine.  Dimethylglycine that is not metabolized in the liver is transported by the circulatory system to body tissue.  Dimethylglycine was popular with Russian athletes and cosmonauts owing to its reputed ability to increase endurance and reduce fatigue.  DMG is also a byproduct of homocysteine metabolism. Homocysteine and betaine are converted to methionine and N, N-dimethylglycine by betaine-homocysteine methyltransferase. 

# Synonyms:
(Dimethylamino)acetate; (Dimethylamino)acetic acid; 2-(Dimethylamino)acetate; 2-(Dimethylamino)acetic acid; Dimethylglycine; N,N-Dimethylaminoacetate; N,N-Dimethylaminoacetic acid; N,N-Dimethylglycine; N-Methylsarcosine N,N-dimethyl-Glycine

# Chemical_IUPAC_Name:
2-dimethylaminoacetic acid

# Chemical_Formula:
C4H9NO2

# Chemical_Structure:
tbl_chemical:::HMDB00092_ZOOM.png:::119283184591294374

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00092_THUMB.png:::119283184433965179

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
tertiary amine; tertiary aliphatic amine (trialkylamine); carboxylic acid

# Taxonomy_Biofunction:
Component of Glycine, serine and threonine metabolism; Component of Methionine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
103.06333

# Molecular_Weight_Avg:
103.11977

# Smiles_String_isomeric:
CN(C)CC(O)=O

# Smiles_String_canonical:
CN(C)CC(O)=O

# KEGG_Compound_ID:
C01026

# BioCyc_ID:
DIMETHYL-GLYCINE

# PubChem_CID:
673

# PubChem_SID:
540719; 6436203; 7887091; 5342597; 2658; 8145495; 10346268; 589771; 3140091; 8150737; 10346271; 4271; 6436173; 838369; 212878

# OMIM_ID:
268900; 605850

# Metagene_ID:
DIMETHYLGLYCINURIA: 508

# BiGG_ID:
36652

# Wikipedia_ID:
Dimethylglycine

# METLIN_ID:
277

# Ref_ID:
10767172; 11380830; 10102904; 10994627; 11122247; 15562374; 10876657; 9732980; 11231903; 11133459

# ChEBI_ID:
17724

# CAS_Registry_Number:
1118-68-9

# InChI:
InChI=1/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7)

# Synthesis_Reference:
a-Substituted phosphonates. 38. 1-Dimethylamino-1-cyanomethanephosphonic acid diethyl ester, a new approach to the preparation of carboxylic acids, 1-cyanoenamines, and homoenolates.     Costisella, Burkhard; Gross, Hans.    Zentralinst. Org. Chem.,  DAW,

# Melting_Point:
185.5 oC

# Melting_Point_predicted:
26.9 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
298.0 mg/mL [MEYLAN,WM et al. (1996)]; 939.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-2.91 [TSAI,RS ET AL. (1991)]

# LogP_predicted:
-1.69 [Predicted by ALOGPS]; -0.6 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00092_MSDS_1.pdf:::263745221410697>>>tbl_chemical:::HMDB00092_MSDS_2.html:::238620683688788

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Dimethylglycine.mol:::1132723806656309352

# SDF_File_[Text]:
tbl_chemical:::HMDB00092.sdf:::119283184133576482

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00092.pdb:::119283184297345349

# PDB_ID:
1EL5

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1EL5.txt:::1132720901093590335

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041201_P06_10_IS_1DP_presat.png:::114685043636338475

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041201_P06_10_IS_1DP_presat.zip:::114685043637021760

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041201_P06_10_IS_1DP_Assigned.png:::114685043638399252

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::041201_P06_10_IS_1DC_72.jpg:::114168459240884068

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041201_P06_10_IS_1DC_72.zip:::114168459235989627

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041201_P06_10_IS_1DC_72_Assigned.jpg:::114322918752746160

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041201_P06_10_IS_2DHSQC_35.jpg:::114617497345181576

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041201_P06_10_IS_2DHSQC_35.zip:::114617497346123853

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041201_P06_10_IS_2DHSQC_35_Assigned.png:::115964569993320641

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Dimethylglycine.gif:::1132732107437292977

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00092_peaks.txt:::115630953896161143

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Dimethylglycine_C.gif:::1132737680661664203

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00092_peaks.txt:::1156310729264453448

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00092L.png:::117555266439412502; Medium Energy:tbl_ms:::HMDB00092M.png:::117555270479849901; High Energy:tbl_ms:::HMDB00092H.png:::117555272504120815

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000241.png:::116890832625054847

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000241.txt:::116890832646836565

# Cellular_Location:
Cytoplasm; mitochondria

# Tissue_Location:
Liver; Kidney

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	6.2 (0.8-11.2)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9732980
Urine	3.4 (0.7-10.6)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	15562374 
Blood	2.6 (1.8-3.7)	uM	Adult:>18_yrs_old	Both	Normal	11380830 
Blood	1.9 (1.1-3.4)	uM	Adult:>18_yrs_old	Both	Normal	15562374


# Concentration_[Abnormal]:
Blood	4.8 (3.6-6.2)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Chronic Renal failure	11380830


# Associated_Disorders:
Barrett's Esophagus; Cardiovascular Disease; Chronic Renal failure; Cobalamin Deficiency; Congenital Folate Malabsorption; Dysplasia; Formiminotransferase Deficiency; Homocysteinemia; Imerslund-Grasbeck Syndrome (IGS); Intrinsic Factor Deficiency; Neoplasia; Severe Methylenetetrahydrofolate Reductase Deficiency; Transcobalamin Deficiency

# Pathway_Names:
Methionine metabolism

# Pathway_Images:
Methionine_Metabolism.jpg

# KEGG_Images:
map00271

# Pathway_Graphs:
Methionine_Metabolism_Graph.jpg

# Pathway_SBMLs:
Methionine_Metabolism.xml

# Metabolic_Enzyme_1_ID:
5435

# Metabolic_Enzyme_1_Name:
Dimethylglycine dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
ME2GLYDH

# Metabolic_Enzyme_1_Gene_Name:
DMGDH

# Metabolic_Enzyme_1_Protein_Sequence:
>Dimethylglycine dehydrogenase, mitochondrial precursor
MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCV
GVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLE
EETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK
VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMR
ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYL
RQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK
KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEP
PFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLES
KCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVGVTDLSPFGKF
NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSE
LHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTPEDLSDDVFKFLQTK
SLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL
EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLATD
DVDPEGNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEVELLGKNYPA
VIIQEPLVLTEPTRNRLQKKGGKDKT

# Metabolic_Enzyme_1_Number_of_Residues:
866

# Metabolic_Enzyme_1_Molecular_Weight:
96808

# Metabolic_Enzyme_1_Theoretical_pI:
7.69

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  aminomethyltransferase activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
Process:  glycine catabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
N,N-dimethylglycine + acceptor + H(2)O = sarcosine + formaldehyde + reduced acceptor

# Metabolic_Enzyme_1_Pathway:
map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_1_Reaction:
N,N-dimethylglycine + acceptor + H2O = sarcosine + formaldehyde + reduced acceptor

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01266:DAO;
PF01571:GCV_T;
PF08669:GCV_T_C

# Metabolic_Enzyme_1_Signals:
1-23

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.5.99.2

# Metabolic_Enzyme_1_GenBank_ID_Protein:
6650622

# Metabolic_Enzyme_1_SwissProt_ID:
M2GD_HUMAN (Q9UI17)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
DMGDH

# Metabolic_Enzyme_1_Geneatlas_id:
DMGDH

# Metabolic_Enzyme_1_hgnc_id:
HGNC:24475

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_1_Gene_Sequence:
>2601 bp
ATGCTCCGTCCCGGCGCGCAGCTGCTGCGGGGCCTCCTGCTGCGGAGCTGCCCGCTGCAG
GGCTCCCCCGGGCGCCCGCGCTCTGTCTGCGGCCGGGAAGGAGAGGAAAAACCACCCTTA
TCTGCAGAAACACAATGGAAAGACAGAGCAGAAACAGTGATAATTGGAGGTGGCTGTGTT
GGTGTGAGTCTGGCTTATCACCTGGCCAAAGCAGGGATGAAAGATGTGGTCCTGCTGGAG
AAATCAGAGCTCACGGCTGGATCTACCTGGCACGCAGCAGGTTTAACAACTTACTTTCAT
CCTGGAATAAACTTGAAGAAAATACATTATGATAGCATCAAACTTTATGAGAAACTGGAA
GAAGAAACTGGTCAGGTGGTGGGATTCCATCAGCCAGGTAGTATCAGACTTGCTACCACC
CCTGTAAGGGTAGATGAATTTAAATATCAAATGACTCGGACTGGCTGGCATGCAACAGAA
CAGTATCTCATTGAACCTGAAAAAATTCAAGAGATGTTCCCTTTACTCAACATGAATAAG
GTTTTAGCTGGATTGTATAATCCTGGAGATGGTCACATTGATCCTTATTCTCTAACTATG
GCACTGGCTGCTGGGGCTAGGAAATGTGGTGCCCTTTTAAAATATCCTGCACCAGTAACT
TCTCTGAAAGCCAGGTCAGATGGAACATGGGACGTTGAAACACCACAGGGGTCTATGAGA
GCAAATAGAATTGTGAATGCTGCAGGATTTTGGGCTCGTGAAGTAGGTAAAATGATTGGA
CTAGAACATCCTCTCATTCCGGTTCAACATCAATATGTTGTTACATCGACTATATCTGAA
GTGAAAGCTTTGAAACGAGAACTGCCTGTGCTCCGTGACCTGGAAGGATCATATTATCTC
CGACAGGAAAGGGATGGGCTTTTGTTTGGTCCATATGAAAGTCAAGAGAAAATGAAAGTT
CAGGACTCCTGGGTCACCAATGGAGTTCCTCCAGGTTTTGGAAAGGAACTCTTTGAGTCT
GATCTAGATCGAATCATGGAACACATCAAAGCTGCCATGGAAATGGTTCCTGTCTTGAAA
AAGGCTGACATCATCAATGTTGTCAATGGTCCTATCACGTATTCTCCTGACATTCTGCCT
ATGGTGGGGCCCCATCAGGGGGTCAGAAACTACTGGGTGGCTATAGGCTTTGGATATGGC
ATAATCCACGCTGGTGGGGTAGGGAAATATCTCAGTGACTGGATCCTGCATGGAGAACCT
CCTTTTGATCTGATAGAATTGGATCCTAATCGCTATGGCAAATGGACAACAACCCAGTAC
ACTGAGGCCAAAGCAAGAGAATCATATGGATTCAACAATATTGTTGGTTATCCTAAAGAA
GAACGGTTTGCTGGGAGGCCGACTCAACGAGTCAGTGGGCTCTATCAAAGGCTGGAGTCT
AAGTGTTCCATGGGGTTCCATGCTGGCTGGGAGCAGCCGCACTGGTTCTACAAACCAGGC
CAGGACACTCAGTACAGGCCAAGTTTTCGCCGCACAAACTGGTTTGAGCCTGTGGGCTCG
GAGTATAAACAGGTTATGCAAAGAGTAGGGGTAACTGACCTATCACCATTTGGCAAGTTT
AACATCAAAGGCCAAGATTCCATTAGACTACTGGACCATCTCTTTGCAAATGTCATTCCA
AAGGTGGGTTTTACAAATATAAGTCACATGTTAACACCCAAGGGTCGAGTGTATGCTGAG
CTGACTGTTTCTCACCAATCTCCTGGGGAGTTTCTTTTAATTACTGGCTCTGGATCAGAA
CTTCATGATCTTAGATGGATTGAAGAAGAAGCAGTCAAAGGTGGATATGATGTTGAAATT
AAAAACATAACTGATGAGCTTGGAGTTCTTGGAGTTGCTGGGCCACAGGCAAGAAAGGTC
CTTCAGAAACTGACCCCTGAAGATCTTAGTGATGATGTTTTCAAGTTTCTTCAAACCAAG
TCCTTAAAGGTTTCCAACATTCCTGTCACTGCTATTAGGATATCTTATACTGGTGAGCTG
GGTTGGGAGCTGTATCACAGAAGAGAAGATTCTGTGGCGCTGTATGACGCTATCATGAAT
GCAGGCCAGGAGGAGGGAATCGACAATTTTGGAACCTATGCCATGAATGCCTTACGCCTG
GAGAAAGCCTTCAGAGCCTGGGGGTTAGAGATGAACTGTGATACAAATCCTTTGGAAGCT
GGACTGGAATATTTTGTGAAGTTAAATAAGCCAGCAGACTTCATAGGAAAGCAAGCACTG
AAACAGATTAAAGCCAAGGGGCTGAAACGAAGACTGGTCTGCCTCACCTTGGCAACGGAT
GATGTTGATCCAGAGGGAAATGAAAGCATCTGGTACAATGGCAAGGTGGTTGGCAACACG
ACATCTGGAAGCTATAGCTACAGCATCCAGAAGAGTCTGGCTTTCGCATATGTCCCTGTA
CAACTAAGTGAAGTGGGACAGCAAGTGGAAGTTGAACTATTAGGCAAAAATTACCCAGCA
GTCATCATACAAGAACCTTTGGTATTGACCGAACCAACCAGAAACCGGCTTCAGAAAAAA
GGTGGAAAGGACAAAACTTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF111858

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_1_Locus:
5q14.1

# Metabolic_Enzyme_1_SNPs:
rs532964; rs1805074; rs1805073; rs248385; rs1805072; rs2253262; rs877052; rs642013; rs661620; rs2303129; rs463614; rs248383; rs2445887; rs1990900; rs2364143; rs185077; rs731123; rs2249096; rs731124; rs2034900; rs479405; rs248381; rs570207; rs542721; rs476620; rs7731142; rs6862283; rs1984685; rs248378; rs6877698; rs42418; rs6859544; rs3797538; rs933684; rs727674; rs3797539; rs402701; rs190335; rs248386; rs96525; rs2049163; rs2272038; rs6865893; rs705418; rs2034899; rs2461249; rs28326; rs9637824; rs7735031; rs6453424; rs620376; rs11953102; rs250513; rs7709472; rs1644004; rs152259; rs3797535; rs7709757; rs3797537; rs3864262; rs6453425; rs16876428; rs6873326; rs631151; rs10514152; rs490270; rs556961; rs16876318; rs248384; rs11960388; rs16876431; rs584218; rs921943; rs1673137; rs10514153; rs2431951; rs604315; rs531982; rs6881725; rs2306193; rs612893; rs2204060; rs6877621; rs16876397; rs556013; rs933683; rs3914914; rs7705204; rs10514154; rs17823816; rs248380; rs2303128; rs17223387; rs7710133; rs10065798; rs16876289; rs16876358; rs7710824; rs6887869; rs544424; rs441048; rs248376; rs16876363; rs6860801; rs7709325; rs7701195; rs10514151; rs11951068; rs6880428; rs1085392; rs16876356; rs10056330; rs16876411; rs4512118; rs2947610; rs16876442; rs4288103; rs11949663; rs16876470; rs7716612; rs16876367; rs403224; rs11952315; rs664528; rs2431332; rs248379; rs7704913; rs17823642; rs7703901; rs786155; rs96523; rs3797541; rs4021023; rs7736027; rs248377; rs16876438; rs7731290; rs1862228; rs16876472; rs17823744; rs7710910; rs16876277; rs16876440; rs7703917; rs16876255; rs16876394; rs7736348; rs664512; rs16876302; rs1478407; rs2431330; rs7711083; rs571253; rs16876336; rs16876413; rs686724; rs7703785; rs495287; rs475058; rs475156; rs7711397; rs16876451; rs16876404; rs17823774; rs473274; rs3797536; rs7736178; rs653275; rs4318760; rs7724552; rs6878926; rs7703637; rs16876393; rs495305; rs16876468; rs4537039; rs3797540; rs7727943; rs6883815; rs10514156; rs540979; rs705415; rs9687295; rs41272262; rs36216309; rs35178358; rs4482887; rs11557328; rs35265763; rs4020528; rs10540579; rs35837828; rs2947609; rs11300742; rs7714436; rs1984686; rs35178322; rs6888663; rs635859; rs35854183; rs511535; rs34300463; rs2067344; rs6868881; rs5868947; rs4021026; rs35656285; rs1879618; rs34901352; rs33941269; rs32971; rs33979164; rs7724345; rs33962286; rs16876371; rs3214458; rs5868944; rs41272266; rs685881; rs6861362; rs41272268; rs11329349; rs6453427; rs11283865; rs11951916; rs10474572; rs34367853; rs5868948; rs2886128; rs4021027; rs35139873; rs28379156; rs32970; rs34668370; rs34171221; rs2004599; rs34333283; rs5868943; rs582972; rs486685; rs34210037; rs2445886; rs3215302; rs36222086; rs35123793; rs3797544; rs984423; rs11959058; rs495544; rs34000417; rs34289209; rs34931005; rs1085391; rs34234265; rs7705658; rs35508403; rs11743895; rs11279417; rs6868551; rs35928127; rs10041584; rs28445067; rs41272260; rs3952395; rs34398829; rs1533761; rs35873754; rs13181176; rs35065766; rs28681027; rs10594571; rs11743856; rs3214906; rs16876305; rs41272264; rs5868946; rs34643699; rs10588876; rs34589354; rs34694367; rs35879437; rs35508115; rs1422086; rs152727; rs163132; rs163133; rs336525; rs336526; rs402208; rs477020; rs478651; rs509119; rs592052; rs626105; rs627409; rs642431; rs642934; rs644191; rs663646; rs670220; rs673752; rs673834; rs682985; rs7705926; rs7718728; rs9293761

# Metabolic_Enzyme_1_General_References:
10767172; 11231903; 10102904

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5831

# Metabolic_Enzyme_2_Name:
Betaine--homocysteine S-methyltransferase 1

# Metabolic_Enzyme_2_Synonyms:
Not Available

# Metabolic_Enzyme_2_Gene_Name:
BHMT

# Metabolic_Enzyme_2_Protein_Sequence:
>Betainehomocysteine Smethyltransferase 1
MPPVGGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLH
REFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIARQVADEGDALVAG
GVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKP
VAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARL
KAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCC
GFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASG
RPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFEKQKFKSQ

# Metabolic_Enzyme_2_Number_of_Residues:
406

# Metabolic_Enzyme_2_Molecular_Weight:
44999

# Metabolic_Enzyme_2_Theoretical_pI:
7.04

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  S-methyltransferase activity
Function:  homocysteine S-methyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline

# Metabolic_Enzyme_2_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00271  Methionine metabolism

# Metabolic_Enzyme_2_Reaction:
trimethylammonioacetate + L-homocysteine = dimethylglycine + L-methionine

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF02574:S-methyl_trans

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.1.1.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1522683

# Metabolic_Enzyme_2_SwissProt_ID:
BHMT1_HUMAN (Q93088)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
BHMT

# Metabolic_Enzyme_2_Geneatlas_id:
BHMT

# Metabolic_Enzyme_2_hgnc_id:
HGNC:1047

# Metabolic_Enzyme_2_PDB_ID:
1LT8

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1221 bp
ATGCCACCCGTTGGGGGCAAAAAGGCCAAGAAGGGCATCCTAGAACGTTTAAATGCTGGA
GAGATTGTGATTGGAGATGGAGGGTTTGTCTTTGCACTGGAGAAGAGGGGCTACGTAAAG
GCAGGACCCTGGACTCCTGAAGCTGCTGTGGAGCACCCAGAAGCAGTTCGCCAGCTTCAT
CGAGAGTTCCTCAGAGCTGGCTCAAACGTCATGCAGACCTTCACCTTCTATGCGAGTGAA
GACAAGCTGGAGAACAGGGGCAACTATGTCTTAGAGAAGATATCTGGGCAGGAAGTCAAT
GAAGCTGCTTGCGACATCGCCCGACAAGTGGCTGATGAAGGAGATGCTTTGGTAGCAGGA
GGAGTGAGTCAGACACCTTCATACCTTAGCTGCAAGAGTGAAACTGAAGTCAAAAAAGTA
TTTCTGCAACAGTTAGAGGTCTTTATGAAGAAGAACGTGGACTTCTTGATTGCAGAGTAT
TTTGAACACGTTGAAGAAGCTGTGTGGGCAGTTGAAACCTTGATAGCATCCGGTAAACCT
GTGGCAGCAACCATGTGCATTGGCCCAGAAGGAGATTTGCATGGCGTGCCCCCCGGCGAG
TGTGCAGTGCGCCTGGTGAAAGCAGGAGCATCCATCATTGGTGTGAACTGCCACTTTGAC
CCCACCATTAGTTTAAAAACAGTGAAGCTCATGAAGGAGGGCTTGGAGGCTGCCCAACTG
AAAGCTCACCTGATGAGCCAGCCCTTGGCTTACCACACTCCTGACTGCAACAAGCAGGGA
TTCATCGATCTCCCAGAATTCCCATTTGGACTGGAACCCAGAGTTGCCACCAGATGGGAT
ATTCAAAAATACGCCAGAGAGGCCTACAACCTGGGGGTCAGGTACATTGGCGGGTGCTGT
GGATTTGAGCCCTACCACATCAGGGCAATTGCAGAGGAGCTGGCCCCAGAAAGGGGCTTT
TTGCCACCAGCTTCAGAAAAACATGGCAGCTGGGGAAGTGGTTTGGACATGCACACCAAA
CCCTGGGTTAGAGCAAGGGCCAGGAAGGAATACTGGGAGAATCTTCGGATAGCCTCAGGC
CGGCCATACAACCCTTCAATGTCAAAGCCAGATGGCTGGGGAGTGACCAAAGGAACAGCC
GAGCTGATGCAGCAGAAAGAAGCCACAACTGAGCAGCAGCTGAAAGAGCTCTTTGAAAAA
CAAAAATTCAAATCACAGTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
U50929

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_2_Locus:
5q13.1-q15

# Metabolic_Enzyme_2_SNPs:
rs3733890; rs585800; rs1002735; rs1050824; rs542852; rs649514; rs492842; rs651852; rs567754; rs6453430; rs10037045; rs506500; rs6862287; rs6875201; rs6894156; rs7700970; rs3797546; rs621678; rs622087; rs694290; rs16876548; rs4421087; rs10474577; rs573372; rs558133; rs612855; rs34504683; rs16876528; rs16876527; rs6893970; rs6860725; rs478667; rs16876547; rs34004238; rs686764; rs619100; rs1862227; rs11955042; rs35815247; rs3756548; rs562487; rs16876512; rs3756547; rs10037809; rs672347; rs1050825; rs672346; rs11541208; rs35041410; rs4703772; rs1804620; rs2909853; rs13164347; rs6893715; rs13160271; rs35064627; rs35826365; rs918417; rs34861837; rs34308482; rs35913757; rs34267463; rs35639243; rs1644005; rs35373899; rs5868950; rs35563215; rs4020527; rs35261961; rs35571558; rs10071440; rs35884202; rs34576335; rs7722216; rs10044894; rs35617181; rs11955653; rs1316776; rs1627316; rs16876498; rs16876500; rs16876503; rs1717566; rs1915705; rs1915706; rs2364596; rs2461248; rs2909854; rs490268; rs586199; rs600473; rs603896; rs617219; rs631305; rs644623; rs645112; rs7356530; rs7732845; rs955897; rs964320

# Metabolic_Enzyme_2_General_References:
8798461; 10075673; 9281325; 9681996; 12818402

# Metabolic_Enzyme_2_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8745

# Macromolecular_Interacting_Partner_1_Name:
CDNA FLJ20001 fis, clone ADKA01273

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>CDNA FLJ20001 fis, clone ADKA01273
MEFLRAGSNVMQTFTFSASEDNMESKWEDVNAAACDLAREVAGKGDALVAGGICQTSIYK
YQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRPVAVTMCIGP
EGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPL
GFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRA
IAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSK
PDF

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
303

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
33907

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.28

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  S-methyltransferase activity
Function:  homocysteine S-methyltransferase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_1_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF02574:S-methyl_trans

# Macromolecular_Interacting_Partner_1_Signals:
Not Available

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
7019812

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
Q9NXX7_HUMAN (Q9NXX7)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
BHMT2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
BHMT2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:1048

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>912 bp
ATGGAATTCTTGAGAGCAGGATCAAATGTCATGCAGACTTTTACCTTTTCTGCCAGTGAG
GACAATATGGAAAGCAAGTGGGAAGATGTAAATGCTGCTGCCTGTGACCTCGCCAGGGAA
GTGGCTGGCAAAGGTGATGCTTTGGTAGCAGGGGGGATCTGCCAGACATCAATATACAAA
TACCAGAAGGATGAAGCTAGAATTAAAAAACTTTTTCGACAACAGCTAGAAGTTTTTGCC
TGGAAAAATGTGGACTTCTTGATTGCAGAGTATTTTGAGCACGTTGAAGAAGCTGTGTGG
GCTGTGGAAGTCTTAAAAGAATCAGATAGACCCGTGGCAGTTACCATGTGCATAGGCCCA
GAGGGAGACATGCATGATATAACCCCCGGAGAATGTGCTGTGAGGCTGGTGAAGGCAGGG
GCTTCCATCGTTGGCGTGAACTGCCGCTTTGGGCCCGACACCAGCTTGAAGACGATGGAG
CTCATGAAGGAGGGTCTTGAGTGGGCAGGGCTGAAAGCGCACCTCATGGTGCAGCCTCTG
GGGTTCCACGCGCCTGACTGTGGCAAAGAGGGGTTTGTGGATCTCCCAGAATATCCCTTT
GGACTGGAGTCCAGAGTTGCCACCAGATGGGATATTCAAAAATACGCCAGAGAGGCCTAC
AACCTGGGGGTCAGGTACATTGGCGGGTGCTGTGGATTTGAGCCCTACCACATCAGGGCA
ATTGCAGAGGAGCTGGCCCCAGAAAGGGGCTTTTTGCCACCAGCTTCAGAAAAACACGGC
AGCTGGGGAAGTGGTTTGGACATGCACACCAAACCCTGGATTAGAGCAAGGGCTCGAAGG
GAGTATTGGGAGAATCTGCTGCCAGCTTCAGGCAGACCTTTCTGTCCTTCGCTGTCAAAG
CCAGACTTCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AK000008

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Locus:
Not Available

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
Not Available

# Macromolecular_Interacting_Partner_1_References:
Not Available

End of HMDB00092

Beginning of HMDB00094
# Accession_No:
HMDB00094

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-23 14:01:18

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Citric acid

# Description:
Citric acid (citrate) is a weak acid that is formed in the tricarboxylic acid cycle or that may be introduced with diet. The evaluation of plasma citric acid is scarcely used in the diagnosis of human diseases. On the contrary urinary citrate excretion is a common tool in the differential diagnosis of kidney stones, renal tubular acidosis and it plays also a role in bone diseases. The importance of hypocitraturia should be considered with regard to bone mass, urine crystallization and urolithiasis. (PMID 12957820) The secretory epithelial cells of the prostate gland of humans and other animals posses a unique citrate-related metabolic pathway regulated by testosterone and prolactin.  This specialized hormone-regulated metabolic activity is responsible for the major prostate function of the production and secretion of extraordinarily high levels of citrate.  The key regulatory enzymes directly associated with citrate production in the prostate cells are mitochondrial aspartate aminotransferase, pyruvate dehydrogenase, and mitochondrial aconitase.  Testosterone and prolactin are involved in the regulation of the corresponding genes associated with these enzymes.  The regulatory regions of these genes contain the necessary response elements that confer the ability of both hormones to control gene transcription. Protein kinase c (PKC) is the signaling pathway for the prolactin regulation of the metabolic genes in prostate cells.  Testosterone and prolactin regulation of these metabolic genes (which are constitutively expressed in all mammalian cells) is specific for these citrate-producing cells. (PMID 12198595) Citric acid is found in citrus fruits, most concentrated in lemons and limes, where it can comprise as much as 8% of the dry weight of the fruit. Citric acid is a natural preservative and is also used to add an acidic (sour) taste to foods and soft drinks. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability. Intolerance to citric acid in the diet is known to exist. Little information is available as the condition appears to be rare, but like other types of food intolerance it is often described as a "pseudo-allergic" reaction.

# Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate; 2-Hydroxy-1,2,3-propanetricarboxylic acid; 3-Carboxy-3-hydroxypentane-1,5-dioate; 3-Carboxy-3-hydroxypentane-1,5-dioic acid; Aciletten; Anhydrous citrate; Anhydrous citric acid; Chemfill; Citraclean; Citrate; Citretten; Citric acid; Citro; E 330; Hydrocerol A; Kyselina citronova; Suby G; Uro-trainer; beta-Hydroxytricarballylate; beta-Hydroxytricarballylic acid

# Chemical_IUPAC_Name:
2-hydroxypropane-1,2,3-tricarboxylic acid

# Chemical_Formula:
C6H8O7

# Chemical_Structure:
tbl_chemical:::HMDB00094_ZOOM.png:::119283185498677897

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00094_THUMB.png:::11928318533871144

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
tertiary alcohol; carboxylic acid; alpha-hydroxyacid

# Taxonomy_Biofunction:
Component of Glyoxylate and dicarboxylate metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
192.02701

# Molecular_Weight_Avg:
192.12354

# Smiles_String_isomeric:
OC(=O)CC(O)(CC(O)=O)C(O)=O

# Smiles_String_canonical:
OC(=O)CC(O)(CC(O)=O)C(O)=O

# KEGG_Compound_ID:
C00158

# BioCyc_ID:
CIT

# PubChem_CID:
311

# PubChem_SID:
10317680; 584546; 854409; 11533259; 10322568; 554966; 584046; 5235138; 584681; 855115; 11109910; 11528474; 855176; 855402; 584199; 8028213; 583709; 10317860; 11459506; 8027781; 584048; 11532236; 10318208; 583785; 584057; 584768; 585511; 584096; 10318194; 11451980; 10322840; 583628; 583961; 8138121; 583624; 10323011; 10528829; 10322173; 539322; 554968; 584052; 583666; 10322380; 149469; 585681; 11539086; 493004; 11491665; 584050; 10322314; 8150570; 11538168; 11532622; 584772; 583962; 11532281; 607173; 854715; 10322601; 583990; 11538718; 11528589; 11457482; 583920; 11451545; 10317866; 854690; 8028216; 587788; 11539084; 554967; 550997; 10322647; 11538706; 583782; 10318011; 11372839; 583952; 551870; 10317855; 584526; 584054; 561246; 10317325; 11532283; 584098; 10317851; 584697; 3132516; 11426934; 583750; 584208; 854407; 10318352; 10403647; 585348; 585694; 10535876; 540850; 583626

# OMIM_ID:
232200; 305900; 602491

# Metagene_ID:
PROPIONIC ACIDEMIA. KETOTIC HYPERGLYCINEMIA (PA): 18; METHYLMALONIC ACIDURIA, cblA TYPE: 328; BIOTINIDASE DEFICIENCY: 73; ARTEFACTS-PHARMACEUTICAL PRODUCTS, INTERFERENCE IN AMINOACID AND ORGANIC ACID ANALYSIS [DD]: 347; FEEDING: AMINO ACID FORMULA [DD]: 341; MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM: 79; METHYLMALONIC ACIDURIA (MMA): 15

# BiGG_ID:
34080

# Wikipedia_ID:
Citric acid

# METLIN_ID:
124

# Ref_ID:
6705419; 11407968; 14724361; 12871333; 15689116; 15172066; 16038021; 16787846; 12234950; 16351159; 9625050; 15132705; 12941351; 12850842; 8412012; 16645424; 7729054; 1931558; 15115669; 15154867

# ChEBI_ID:
16947

# CAS_Registry_Number:
77-92-9

# InChI:
InChI=1/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

# Synthesis_Reference:
Hydrolysis of ethyl methylenecitrate [5,5-bis(ethoxycarbonylmethyl)-1,3-dioxolan-4-one] and an attempted synthesis of agaric acid.     Evans, D. W. S.    Univ. Nottingham,  UK.    Journal of the Chemical Society  (1959),     1313-14.

# Melting_Point:
153 oC

# Melting_Point_predicted:
44.4 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
592.0 mg/mL [MERCK INDEX (1989)]

# H2O_Solubility_Predicted:
106.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
-3

# State:
Solid

# LogP:
-1.64 [AVDEEF,A (1997)]

# LogP_predicted:
-1.33 [Predicted by ALOGPS]; -2.2 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::citric acid.pdf:::1132562199037654087

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Citric_acid.mol:::1132723806765596959

# SDF_File_[Text]:
tbl_chemical:::HMDB00094.sdf:::119283184985297663

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00094.pdb:::119283185197314134

# PDB_ID:
1A59

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1A59.txt:::1132720901234131088

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041024_P00_02_HW_1DP_PRESAT_expanded_2.gif:::114460738832314316

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041024_P00_02_HW_1DP_presat.zip:::1177710620058822006

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041024_P00_02_HW_1DP_Assigned.png:::114660024708387606

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::041024_P00_02_HW_1DC_23.jpg:::114168459820769307

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041024_P00_02_HW_1DC_23.zip:::11416845981794469

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041024_P00_02_HW_1DC_23_Assigned.jpg:::114322920843361862

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041024_P00_02_HW_2DHSQC_84.jpg:::114495607542722886

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041024_P00_02_HW_2DHSQC_84.zip:::114495607545198663

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041024_P00_02_HW_2DHSQC_84_Assigned.jpg:::114495607563565208

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Citric acid.gif:::1132732107875554606

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00094_peaks.txt:::1156309539980101983

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Citric acid_C.gif:::113273768126183551

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00094_peaks.txt:::115631073028391324

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00094L.png:::117555262546923633; Medium Energy:tbl_ms:::HMDB00094M.png:::117555267928559873; High Energy:tbl_ms:::HMDB00094H.png:::117555271490034747

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000076.png:::116899931059338922

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000076.txt:::116899931059381294

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000076.png:::116890825910994574

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000076.txt:::116890825942153443

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	300.0	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9625050
Blood	190.0 (30.0-400.0)	umol/L	Adult:>18_yrs_old	Both	Normal	8412012
Blood	88.0 +/- 33.0	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	122.0 +/- 30.0	uM	Children:1-13_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	319.0	umol/L	Adult:>18_yrs_old	Both	Normal	16351159
Cerebrospinal_Fluid(CSF)	400.0 +/- 170.0	umol/L	Adult:>18_yrs_old	N/A	Normal	1931558
Cerebrospinal_Fluid(CSF)	350.0 +/- 240.0	umol/L	Adult:>18_yrs_old	N/A	Normal	8412012
Cerebrospinal_Fluid(CSF)	792.0 +/- 377.0	uM	Adult:>18_yrs_old	Both	Normal	HMP Experimental
Cerebrospinal_Fluid(CSF)	370.0 (110.0 - 630.0)	umol/L	Adult:>18_yrs_old	Both	Normal	7729054
Cerebrospinal_Fluid(CSF)	176.0 +/- 50.0	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.


# Concentration_[Abnormal]:
Urine	268.0 (53.0-1111.0)	umol/mmol_creatinine	N/A	Both	Lung Cancer	HMP experiment
Urine	11.2	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Paraquat poisoning	9625050
Cerebrospinal_Fluid(CSF)	2400.0	uM	Adult:>18_yrs_old	Both	Canavan Disease	7729054


# Associated_Disorders:
Canavan Disease; Diuresis; Huntington chorea; Liver Insufficiency; Lung Cancer; Paraquat poisoning; Proteinuria

# Pathway_Names:
Glyoxylate and dicarboxylate metabolism;Reductive carboxylate cycle (CO2 fixation)

# Pathway_Images:
;

# KEGG_Images:
map00630;map00720

# Pathway_Graphs:
;

# Pathway_SBMLs:
;

# Metabolic_Enzyme_1_ID:
6000

# Metabolic_Enzyme_1_Name:
Aconitate hydratase, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
Citrate hydro-lyase; Aconitase

# Metabolic_Enzyme_1_Gene_Name:
ACO2

# Metabolic_Enzyme_1_Protein_Sequence:
>Aconitate hydratase, mitochondrial precursor
MAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRLN
RPLTLSEKIV
YGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVA
VPSTIHCDHLIEAQVGGEKDL
RRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIIL
ENYAYPGVLLIGTDSHTPNGGGLGGICIGVGG
ADAVDVMAGIPWELKCPKVIGVKLTGS
LSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGM
ATICNMGAEIGATTSV
FPYNHRMKKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHIN
GPFTP
DLAHPVAEVGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFT
ITPGS
EQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNR
NFTGRNDANPETHAFV
TSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELP
KGEFDPGQDTYQHPPKDSSGQHVDVSP
TSQRLQLLEPFDKWDGKDLEDLQILIKVKGKC
TTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKAN
SVRNAVTQEFGPVPDTARYYK
KHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLK
KQGLLPLTFA
DPADYNKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGS

ALNRMKELQQ

# Metabolic_Enzyme_1_Number_of_Residues:
780

# Metabolic_Enzyme_1_Molecular_Weight:
85426

# Metabolic_Enzyme_1_Theoretical_pI:
7.65

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  aconitate hydratase activity
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-oxygen lyase activity
Function:  hydro-lyase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
 ||
>>>
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  mitochondrion

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
Citrate = cis-aconitate + H(2)O

# Metabolic_Enzyme_1_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00630  Glyoxylate and dicarboxylate metabolism;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_1_Reaction:
citrate = cis-aconitate + H2O

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00330:Aconitase;
PF00694:Aconitase_C

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 4.2.1.3

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1718502

# Metabolic_Enzyme_1_SwissProt_ID:
ACON_HUMAN (Q99798)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ACO2

# Metabolic_Enzyme_1_Geneatlas_id:
ACO2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:118

# Metabolic_Enzyme_1_PDB_ID:
1B0J

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_1_Gene_Sequence:
>2343 bp

ATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTA
CCATGTGGCCT
CAGTCCTGTGCCAACGGGCCAAGGTGGCGATGACGCATTTTGAGCCCA
ACGAGTACATCCATTATGACCT
GCTAGAGAAGAACATTAACATTGTTCGCAAACGACTG
AACCGGCCGCTGACACTCTCGGAGAAGATTGTG
TATGGACACCTGGATGACCCCGCCAG
CCAGGAAATTGAGCGAGGCAAGTCGTACCTGCGGCTGCGGCCCG
ACCGTGTGGCCATGC
AGGATGCGACGGCCCAGATGGCCATGCTCCAGTTCATCAGCAGCGGGCTGTCCAA
GGTG
GCTGTGCCATCCACCATCCACTGTGACCATCTGATTGAAGCCCAGGTTGGGGACGAGAAA
GACCTG
CGCCGGGCCAAGGACATCAACCAGGAAGTTTATAATTTCCTGGCAACTGCAGG
TGACAAGTATGGCGTGG
GCTTCTGGAGCCCTGGATCTGGAATCATTCACCAGATTATTC
TCGAAAACTATGCGTACCCTGGAGTTCT
TCTGATTGGAACTGACTCCCACACCCCCAAT
GGTGGTGGCCTAGGAGGCATCTGCATTGGAGTAGGGGGT
GCAGATGCTGTGGATGTCAT
GGCTGGGATCCCCTGGGAGCTGAAGTGCCCCAAGGTGATTGGCGTGAAGC
TGACGGGCT
CTCTCTCCGGTTGGACCTCACCCAAAGATGTGATCCTGAAGGTGGCAGGCATCCTCACGG
T
GAAAGGTGGCACAGGTGCAATCGTGGAATACCACGGGCCTGGTGTAGACTCCATGTCC
TGCACTGGCATG
GCGACAATCTGCAACATGGGTGCAGAAATTGGGGCCACCACTTCCGT
GTTCCCTTACAACCACAGGATGA
AGAAGTACCTGAGCAAGACCGGCCGGGAAGACATTG
CCAATCTAGCTGATGAATTCAAGGATCACTTGGT
GCCTGACCCTGGCTGCCATTATGAC
CAACTAATTGAAATTAACCTCAGTGAGCTGAAGCCACACATCAAT
GGGCCCTTCACCCC
TGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAGAAGGAAGGATGGC
CTC
TGGACATCCGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGC
GCTCAGC
AGCTGTGGCCAAGCAGGCACTGGCCCATGGACTCAAGTGCAAGTCCCAGTTC
ACCATCACTCCAGGTTCC
GAGCAGATCCGCGCCACCATTGAGCGGGACGGCTATGCACA
GATCCTGAGGGATCTGGGTGGCATTGTCC
TGGCCAATGCCTGCGGGCCCTGCATTGGCC
AGTGGGACAGAAAGGACATCAAGAAGGGGGAGAAGAACAC
AATCGTCACCTCCTACAAC
AGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTTGTC
ACGTCCCC
AGAGATTGTCACAGCCCTGGCCATTGCAGGAACCCTCAAGTTCAACCCAGAGACCGACTA
CC
TGACAGGCAAGGATGGCAAGAAGTTCAGGCTGGAAGCTCCGGATGCAGATGAGCTTC
CCAAAGGGGAGTT
TGACCCAGGGCAGGACACCTACCAGCACCCCCCAAAGGACAGCAGC
AGGCAGCATGTGGACGTGAGCCCC
ACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGA
CAAGTGGGATGGCAAGGACCTGGAGGACCTGCAGA
TCCTCATCAAGGTCAAAGGGAAGT
GTACCACTGACCACATCTCAGCTGCTGGCCCCTGGCTCAAGTTCCG
TGGGCACTTGGAT
AACATCTCCAACAACCTGCTCATTGGTGCCATCAACATTGAAAACGGCAAGGCCAAC
TC
CGTGCGCAATGCCGTCACTCAGGAGTTTGGCCCCGTCCCTGACACTGCCCGCTACTACAA
GAAACATG
GCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCGAGCC
GGGAGCATGCAGCTCTGGA
GCCTCGCCACCTTGGGGGCCGGGCCATCATCACCAAGAGC
TTTGCCAGGATCCACGAGACCAACCTGAAG
AAACAGGGCCTGCTGCCTCTGACCTTCGC
TGACCCGGCTGACTACAACAAGATTCACCCTGTGGACAAGC
TGACCATTCAGGGCCTGA
AGGACTTCACCCCTGGCAAGCCCCTGAAGTGCATCATCAAGCACCCCAACGG
GACCCAG
GAGACCATCCTCCTGAACCACACCTTCAACGAGACGCAGATTGAGTGGTTCCGCGCTGGC
AGT
GCCCTCAACAGAATGAAGGAACTGCAACAGTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U80040

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_1_Locus:
22q11.2-q13.31|22q13.2-q13.31

# Metabolic_Enzyme_1_SNPs:
rs137831; rs1799932; rs203320; rs169361; rs2284080; rs1960182; rs6519256; rs6519257; rs203319; rs12167184; rs5751114; rs12484694; rs2267434; rs2076196; rs12165815; rs6002390; rs2267433; rs5751117; rs9619974; rs9623409; rs79013; rs2267432; rs9611602; rs3827359; rs9623412; rs2413647; rs2267435; rs79011; rs9623411; rs2413645; rs2076199; rs727563; rs6002392; rs203318; rs11090049; rs11705190; rs3045391; rs7290434; rs738140; rs2284081; rs17002483; rs203317; rs8136366; rs1569516; rs17367716; rs7288661; rs9611603; rs7289999; rs202612; rs202610; rs11912852; rs2413646; rs9611604; rs17002487; rs7290508; rs137830; rs5758375; rs2267436; rs12170066; rs9607809; rs9611598; rs5758380; rs2006715; rs11554470; rs17856753; rs1049860; rs1049856; rs17852363; rs1049859; rs11554469; rs1049852; rs1049857; rs17852364; rs5758376; rs28634007; rs9611599; rs13054766; rs5751116; rs35732387; rs36024770; rs8185004; rs6002398; rs5758373; rs3838162; rs760810; rs5751115; rs34344341; rs9607807; rs5996034; rs34289556; rs137832; rs35052987; rs11331024; rs5845502; rs10639444; rs34646526; rs5758374; rs5758372; rs34309135; rs9680659; rs12166976; rs34770725; rs28407070; rs13056499; rs6002396; rs5751113; rs5758371; rs9607808; rs33914175; rs34337889; rs9623407; rs35192350; rs9607810; rs8141415; rs34893746; rs36062011; rs35664977; rs5758379; rs41281289; rs11372053; rs9680658; rs13342919; rs12628178; rs8139104; rs8141184; rs5758370; rs34610631; rs34433589; rs5845503; rs35435675; rs33969654; rs7287931; rs203321; rs9611605; rs9680628; rs34571918; rs34563140; rs5758377; rs35902787; rs9680631; rs34759958; rs7286459; rs41276321; rs9623410; rs34487526; rs9680629; rs2102246; rs137829; rs35270250; rs9623408; rs34742939; rs11705367; rs202609; rs9680630; rs34491448; rs9680654; rs35849502; rs35948127; rs4510317; rs8184972; rs28620979; rs34342736; rs28488294; rs35891403; rs5845504; rs35087813; rs3045393; rs34527134; rs34805234; rs34957102; rs1042972; rs10483211; rs12160340; rs12168565; rs17367849; rs1810460; rs1810461; rs188058; rs19573; rs2008065; rs202631; rs203313; rs203315; rs203316; rs2076197; rs2076198; rs2267430; rs2267431; rs34057431; rs34340787; rs35463585; rs4822032; rs4822034; rs505533; rs5751108; rs5758365; rs5758368; rs5758381; rs5758384; rs79009; rs9611597; rs9611606

# Metabolic_Enzyme_1_General_References:
9630632; 10591208

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5239

# Metabolic_Enzyme_2_Name:
ATP-citrate synthase

# Metabolic_Enzyme_2_Synonyms:
ATP-citrate; pro-S--lyase; Citrate cleavage enzyme

# Metabolic_Enzyme_2_Gene_Name:
ACLY

# Metabolic_Enzyme_2_Protein_Sequence:
>ATPcitrate synthase
MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPD
QLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFY
VCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEI
LASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPP
PFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNE
LANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRA
IRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALG
HRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVP
SPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQK
FYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEG
IPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYV
SRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIG
GTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALK
EAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASF
MTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADH
GPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFV
NKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPN
LILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLK
QGLYRHPWDDISYVLPEHMSM

# Metabolic_Enzyme_2_Number_of_Residues:
1101

# Metabolic_Enzyme_2_Molecular_Weight:
120841

# Metabolic_Enzyme_2_Theoretical_pI:
7.34

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine

# Metabolic_Enzyme_2_Pathway:
map00020  Citrate cycle (TCA cycle)

# Metabolic_Enzyme_2_Reaction:
ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF02629:CoA_binding;
PF00549:Ligase_CoA

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.3.3.8

# Metabolic_Enzyme_2_GenBank_ID_Protein:
28935

# Metabolic_Enzyme_2_SwissProt_ID:
ACLY_HUMAN (P53396)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ACLY

# Metabolic_Enzyme_2_Geneatlas_id:
ACLY

# Metabolic_Enzyme_2_hgnc_id:
HGNC:115

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>3318 bp
ATGTCGGCCAAGGCAATTTCAGAGCAGACGGGCAAAGAACTCCTTTACAAGTTCATCTGT
ACCACCTCAGCCATCCAGAATCGGTTCAAGTATGCTCGGGTCACTCCTGACACAGACTGG
GCCCGCTTGCTGCAGGACCACCCCTGGCTGCTCAGCCAGAACTTGGTAGTCAAGCCAGAC
CAGCTGATCAAACGTCGTGGAAAACTTGGTCTCGTTGGGGTCGACCTCACTCTGGATGGG
GTCAAGTCCTGGCTGAAGCCACGGCTGGGACAGGAAGCCACAGTTGGCAAGGCCACAGGC
TTCCTCAAGAACTTTCTGATCGAGCCCTTCGCCCCCCACAGTCAGGCTGAGGAGTTCTAT
GTCTGCATCTATGCCACCCGAGAAGGGGACTACGTCCTGTTCCACCACGAGGGGGGTGTG
GACGTGGGTGATGTGGACGCCAAGGCCCAGAAGCTGCTTGTTGGCGTGGATGAGAAACTG
AATCCTGAGGACATCAAAAAACACCTGTTGGTCCACGCCCCTGACGACAAGAAAGAAATT
CTGGCCAGTTTTATCTCCGGCCTCTTCAATTTCTACGAGGACTTGTACTTCACCTACCTC
GAGATCAATCCCCTTGTAGTGACCAAAGATGGAGTCTATGTCCTTGACTTGGCGGCCAAG
GTGGACGCCACTGCCGACTACATCTGCAAAGTGAAGTGGGGTGACATCGAGTTCCCTCCC
CCCTTCGGGCGGGTGGCATATCCAGAGGAAGCCTACATTGCAGACCTCGATGCCAAAAGT
GGGGCAAGCCTGAAGCTGACCTTGCTGAACCCCAAAGGGAGGATCTGGACCATGGTGGCC
GGGGGTGGCGCCTCTGTCGTGTACAGCGATACCATCTGTGATCTAGGGGGTGTCAACGAG
CTGGCAAACTATGGGGAGTACTCAGGCGCCCCCAGCGAGCAGCAGACCTATGACTATGCC
AAGACTATCCTCTCCCTCATGACCCGAGAGAAGCACCCAGATGGCAAGATCCTCATCATT
GGAGGCAGCATCGCAAACTTCACCAACGTGGCTGCCACGTTCAAGGGCATCGTGAGAGCA
ATTCGAGATTACCAGGGCCCCCTGAAGGAGCACGAAGTCACAATCTTTGTCCGAAGAGGT
GGCCCCAACTATCAGGAGGGCTTACGGGTGATGGGAGAAGTCGGGAAGACCACTGGGATC
CCCATCCATGTCTTTGGCACAGAGACTCACATGACGGCCATTGTGGGCATGGCCTGGGCA
CCGGCCATCCCCAACCAGCCACCCACAGCGGCCCACACTGCAAACTTTCTCCTCAACGCC
CAGCGGGAGACATCGACTCCAGCCCCCAGCAGGACAGCATCTTTTTATGAGTCCATGGTC
GATGAGGTCAGGGCCGATGAGGTGGCGCCTGCAAAGAAGGCCAAGCCTGCCATGCCACAA
GATTCAGTCCCAAGTCCAAGATCCCTGCAAGGAAAGAGCACCACCCTCTTCAGCCGCCAC
ACCAAGGCCATTGTGTGGGGCATGCAGACCCGGGCCGTGCAAGGCATGCTGGACTTTGAC
TATGTCTGCTCCCGAGACGAGCCCTCAGTGGCTGCCATGGTCTATCCTTTCACTGGGGAC
CACAAGCAGAAGTTTTACTGGGGGCACAAAGAGATCCTGATCCCTGTCTTCAAGAACATG
GCTGATGCCATGAGGAAGCACCCGGAGGTAGATGTGCTCATCAACTTTGCCTCTCTCCGC
TCTGCCTATGACAGCACCATGGAGACCATGAACTATGCCCAGATCCGGACCATCGCCATC
ATAGCTGAAGGCATCCCTGAGGCCCTCACGAGAAAGCTGATCAAGAAGGCGGACCAGAAG
GGAGTGACCATCATCGGACCTGCCACTGTTGGAGGCATCAAGCCTGGGTGCTTTAAGATT
GGCAACACAGGTGGGATGCTGGACAACATCCTGGCCTCCAAACTGTACCCCCAGGCAGCT
GTGGCCTATGTCTCACGTTCCGGAGGCATGTCCAACGAGCTCAACAATATCATCTCTCGG
ACCACGGATGGCGTCTATGAGGGCGTGGCCATTGGTGGGGACAGGTACCCGGGCTCCACA
TTCATGGATCATGTGTTACGCTATCAGGACACTCCAGGAGTCAAAATGATTGTGGTTCTT
GGAGAGATTGGGGGCACTGAGGAATATAAGATTTCCCGGGGCATCAAGGAGGGCCGCCTC
ACTAAGCCCATCGTCTGCTGGTGCATCGGGACGTGTGCCACCATGTTCTCCTCTGAGGTC
CAGTTTGGCCATGCTGGAGCTTGTGCCAACCAGGCTTCTGAAACTGCAGTAGCCAAGAAC
CAGGCTTTGAAGGAAGCAGGAGTGTTTGTGCCCCGGAGCTTTGATGAGCTTGGAGAGATC
ATCCAGTCTGTATACGAAGATCTCGTGGCCAATGGAGTCATTGTACCTGCCCAGGAGGTG
CCGCCCCCAACCGTGCCCATGGACTACTCCTGGGCCAGGGAGCTTGGTTTGATCCGCAAA
CCTGCCTCGTTCATGACCAGCATCTGCGATGAGCGAGGACAGGAGCTCATCTACGCGGGC
ATGCCCATCACTGAGGTCTTCAAGGAAGAGATGGGCATTGGCGGGGCCCTCGGCCTCCTC
TGGTTCCAGAAAAGGTTGCCTAAGTACTCTTGCCAGTTCATTGAGATGTGTCTGATGGTG
ACAGCTGATCACGGGCCAGCCGTCTCTGGAGCCCACAACACCATCATTTGTGCGCGCACC
GCGGTGGAGCTGGTCTCCAGCCTCACCTCGGGGCTGCTCACCATCGGGGATCGGTTTGGG
GGTGCCTTGGATGCAGCAGCCAAGATGTTCAGTAAAGCCTTTGACAGTGGCATTATCCCC
ATGGAGTTTGTGAACAAGATGAAGAAGGAAGGGAAGCTGATCATGGGCATTGGTCACCGA
GTGAAGTCGATAAACAACCCAGACATGCGAGTGCAGATCCTCAAAGATTACGTCAGGCAG
CACTTCCCTGCCACTCCTCTGCTCGATTATGCACTGGAAGTAGAGAAGATTACCACCTCG
AAGAAGCCAAATCTTATCCTGAATGTAGATGGTCTCATCGGAGTCGCATTTGTAGACATG
CTTAGAAACTGTGGGTCCTTTACTCGGGAGGAAGCTGATGAATATATTGACATTGGAGCC
CTCAATGGCATCTTTGTGCTGGGAAGGAGTATGGGGTTCATTGGACACTATCTTGATCAG
AAGAGGCTGAAGCAGGGGCTGTATCGTCATCCGTGGGATGATATTTCATATGTTCTTCCG
GAACACATGAGCATGTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X64330

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_2_Locus:
17q12-q21

# Metabolic_Enzyme_2_SNPs:
rs2304497; rs8065502; rs8071938; rs2164517; rs12952729; rs34427808; rs7217218; rs9899285; rs3816122; rs2304499; rs4796729; rs4796726; rs4796739; rs9916650; rs2013590; rs12937036; rs12452032; rs3744779; rs4796738; rs4458050; rs2304496; rs11079023; rs4427855; rs3816121; rs12948100; rs11870075; rs11079024; rs893009; rs4796734; rs9902501; rs12449367; rs4550498; rs9908955; rs8071234; rs8071627; rs34198442; rs35896706; rs2304498; rs11658553; rs12951392; rs8071753; rs9893264; rs4796728; rs9913772; rs8073046; rs8076301; rs8071567; rs4796619; rs11869983; rs9912300; rs4331383; rs11871744; rs9900635; rs3887424; rs8075051; rs9908748; rs7217282; rs34533754; rs41280076; rs41275673; rs1802730; rs1136262; rs1058875; rs11549566; rs1802732; rs41275675; rs2277697; rs1136263; rs1136265; rs1136264; rs35022178; rs8066188; rs12952040; rs34108392; rs35729326; rs35545409; rs12950195; rs35766790; rs28687610; rs12951230; rs8079193; rs34000320; rs3199521; rs17554637; rs35007223; rs11652326; rs35304970; rs34667330; rs34072894; rs34896136; rs34538738; rs34108340; rs36108288; rs10639270; rs7212183; rs28716734; rs4796733; rs10615655; rs35098851; rs36034413; rs9892975; rs9899956; rs34173466; rs1808787; rs9901122; rs1968494; rs41280074; rs34864368; rs12939810; rs12942132; rs2241776; rs11653607; rs11351286; rs1369940; rs34521322; rs4796727; rs4796736; rs8075945; rs35726439; rs2353029; rs9891068; rs35460072; rs7209507; rs35203873; rs4796735; rs9892971; rs9902783; rs12950954; rs34452604; rs3744780; rs34064871; rs33971470; rs9898328; rs34510712; rs34138027; rs9898658; rs35341709; rs35917664; rs35380266; rs10668805; rs8079008; rs7226147; rs35112137; rs4796732; rs35440320; rs4796618; rs10588919; rs35042526; rs34404612; rs12949430; rs12946315; rs41275671; rs11658461; rs8075053; rs35349291; rs34502702; rs7218879; rs35503193; rs34078258; rs34715943; rs35511115; rs34114513; rs10579354; rs34771282; rs12451784; rs12936330; rs35999637; rs34237316; rs35990081; rs9906048; rs12950660; rs9914829; rs34656066; rs878892; rs11653205; rs28578411; rs8077121; rs6503674; rs34941055; rs8075665; rs12939107; rs1058928; rs11079020; rs2883068; rs35880801; rs7218228; rs7713; rs9303318; rs9905601; rs9912010

# Metabolic_Enzyme_2_General_References:
1371749

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6001

# Metabolic_Enzyme_3_Name:
Iron-responsive element-binding protein 1

# Metabolic_Enzyme_3_Synonyms:
IRE-BP 1; Iron regulatory protein 1; IRP1; Ferritin repressor protein; Aconitate hydratase; Citrate hydro-lyase; Aconitase

# Metabolic_Enzyme_3_Gene_Name:
ACO1

# Metabolic_Enzyme_3_Protein_Sequence:
>Ironresponsive elementbinding protein 1
MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDI
ENILHWNVTQ
HKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCP
ADLVIDHSIQVDFNRRADSLQ
KNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIH
QVNLEYLARVVFDQDGYYYPDSLVGTDSHTTM
IDGLGILGWGVGGIEAEAVMLGQPISM
VLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEF
FGPGVAQLSIADRATI
ANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPS
QDPDF
TQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTF
IYDNT
EFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPG
SGVVTYYLQESGVMPY
LSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLS
GNRNFEGRVHPNTRANYLASPPLVIAY
AIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPT
RDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPS
DKLFFWNSKSTYIKSPPFFEN
LTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRG
LTPREFNSYG
SRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLA

GKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGL
TGQERYTIIIP
ENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMA
K

# Metabolic_Enzyme_3_Number_of_Residues:
889

# Metabolic_Enzyme_3_Molecular_Weight:
98400

# Metabolic_Enzyme_3_Theoretical_pI:
6.66

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  aconitate hydratase activity
Function:  nucleic acid binding
Function:  RNA binding
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-oxygen lyase activity
Function:  hydro-lyase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
This protein also expresses aconitase activity

# Metabolic_Enzyme_3_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00630  Glyoxylate and dicarboxylate metabolism;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_3_Reaction:
citrate = cis-aconitate + H2O

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00330:Aconitase;
PF00694:Aconitase_C

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 4.2.1.3

# Metabolic_Enzyme_3_GenBank_ID_Protein:
33963

# Metabolic_Enzyme_3_SwissProt_ID:
IREB1_HUMAN (P21399)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ACO1

# Metabolic_Enzyme_3_Geneatlas_id:
ACO1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:117

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>2670 bp

ATGAGCAACCCATTCGCACACCTTGCTGAGCCATTGGATCCTGTACAACCAGGAAAGAA
ATTCTTCAATT
TGAATAAATTGGAGGATTCAAGATATGGGCGCTTACCATTTTCGATCA
GAGTTCTTCTGGAAGCAGCCAT
TCGGAATTGTGATGAGTTTTTGGTGAAGAAACAGGAT
ATTGAAAATATTCTACATTGGAATGTCACTCAG
CACAAGAACATAGAAGTGCCATTTAA
GCCTGCTCGTGTCATCCTGCAGGACTTTACGGGTGTGCCCGCTG
TGGTTGACTTTGCTG
CAATGCGTGATGCTGTGAAAAAGTTAGGAGGAGATCCAGAGAAAATAAACCCTGT
CTGC
CCTGCTGATCTTGTAATAGATCATTCCATCCAGGTTGATTTCAACAGAAGGGCAGACAGT
TTACAG
AAGAATCAAGACCTGGAATTTGAAAGAAATAGAGAGCGATTTGAATTTTTAAA
GTGGGGTTCCCAGGCTT
TTCACAACATGCGGATTATTCCCCCTGGCTCAGGAATCATCC
ACCAGGTGAATTTGGAATATTTGGCAAG
AGTGGTATTTGATCAGGATGGATATTATTAC
CCAGACAGCCTCGTGGGCACAGACTCGCACACTACCATG
ATTGATGGCTTGGGCATTCT
TGGTTGGGGTGTCGGTGGTATTGAAGCAGAAGCTGTCATGCTGGGTCAGC
CAATCAGTA
TGGTGCTTCCTCAGGTGATTGGCTACAGGCTGATGGGGAAGCCCCACCCTCTGGTAACAT
C
CACTGACATCGTGCTCACCATTACCAAGCACCTCCGCCAGGTTGGGGTAGTGGGCAAA
TTTGTCGAGTTC
TTCGGGCCTGGAGTAGCCCAGTTGTCCATTGCTGACCGAGCTACGAT
TGCTAACATGTGTCCAGAGTACG
GAGCAACTGCTGCCTTTTTCCCAGTTGATGAAGTTA
GTATCACGTACCTGGTGCAAACAGGTCGTGATGA
AGAAAAATTAAAGTATATTAAAAAA
TATCTTCAGGCTGTAGGAATGTTTCGAGATTTCAATGACCCTTCT
CAAGACCCAGACTT
CACCCAGGTTGTGGAATTAGATTTGAAAACAGTAGTGCCTTGCTGTAGTGGACCCA
AAA
GGCCTCAGGACAAAGTTGCTGTGTCCGACATGAAAAAGGACTTTGAGAGCTGCCTTGGAG
CCAAGCA
AGGATTTAAAGGATTCCAAGTTGCTCCTGAACATCATAATGACCATAAGACC
TTTATCTATGATAACACT
GAATTCACCCTTGCTCATGGTTCTGTGGTCATTGCTGCCAT
TACTAGCTGCACAAACACCAGTAATCCGT
CTGTGATGTTAGGGGCAGGATTGTTAGCAA
AGAAAGCTGTGGATGCTGGCCTGAACGTGATGCCTTACAT
CAAAACTAGCCTGTCTCCT
GGGAGTGGCGTGGTCACCTACTACCTACAAGAAAGCGGAGTCATGCCTTAT
CTGTCTCA
GCTTGGGTTTGACGTGGTGGGCTATGGCTGCATGACCTGCATTGGCAACAGTGGGCCTTT
AC
CTGAACCTGTGGTAGAAGCCATCACACAGGGAGACCTTGTAGCTGTTGGAGTACTAT
CTGGAAACAGGAA
TTTTGAAGGTCGAGTTCACCCCAACACCCGGGCCAACTATTTAGCC
TCTCCCCCCTTAGTAATAGCATAT
GCAATTGCTGGAACCATCAGAATCGACTTTGAGAA
AGAGCCATTGGGAGTAAATGCAAAGGGACAGCAGG
TATTTCTGAAAGATATCTGGCCGA
CTAGAGACGAGATCCAGGCAGTGGAGCGTCAGTATGTCATCCCGGG
GATGTTTAAGGAA
GTCTATCAGAAAATAGAGACTGTGAATGAAAGCTGGAATGCCTTAGCAACCCCATCA
GA
TAAGCTGTTTTTCTGGAATTCCAAATCTACGTATATCAAATCACCACCATTCTTTGAAAA
CCTGACTT
TGGATCTTCAGCCCCCTAAATCTATAGTGGATGCCTATGTGCTGCTAAATT
TGGGAGATTCGGTAACAAC
TGACCACATCTCCCCAGCTGGAAATATTGCAAGAAACAGT
CCTGCTGCTCGCTACTTAACTAACAGAGGC
CTAACTCCACGAGAATTCAACTCCTATGG
CTCCCGCCGAGGTAATGACGCCGTCATGGCACGGGGAACAT
TTGCCAACATTCGCTTGT
TAAACAGATTTTTGAACAAGCAGGCACCACAGACTATCCATCTGCCTTCTGG
GGAAATC
CTTGATGTGTTTGATGCTGCTGAGCGGTACCAGCAGGCAGGCCTTCCCCTGATCGTTCTG
GCT
GGCAAAGAGTACGGTGCAGGCAGCTCCCGAGACTGGGCAGCTAAGGGCCCTTTCCT
GCTGGGAATCAAAG
CCGTCCTGGCCGAGAGCTACGAGCGCATTCACCGCAGTAACCTGG
TTGGGATGGGTGTGATCCCACTTGA
ATATCTCCCTGGTGAGAATGCAGATGCCCTGGGG
CTCACAGGGCAAGAACGATACACTATCATTATTCCA
GAAAACCTCAAACCACAAATGAA
AGTCCAGGTCAAGCTGGATACTGGCAAGACCTTCCAGGCTGTCATGA
GGTTTGACACTG
ATGTGGAGCTCACTTATTTCCTCAACGGGGGCATCCTCAACTACATGATCCGCAAGAT
G
GCCAAGTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
Z11559

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_3_Locus:
9p22-q32|9p22-p13

# Metabolic_Enzyme_3_SNPs:
rs34630459; rs3780473; rs34319839; rs35370505; rs1041321; rs4495514; rs7028085; rs882812; rs1028932; rs7033149; rs6476361; rs5005316; rs7028748; rs913762; rs10813809; rs10813808; rs1041320; rs12985; rs10970952; rs10738885; rs7847742; rs10970961; rs10813810; rs7873764; rs10813805; rs7866419; rs4297112; rs1854529; rs10970953; rs12551359; rs7850888; rs10813807; rs11787823; rs10970951; rs11999526; rs1854530; rs10117433; rs7034950; rs13302577; rs7037696; rs7873763; rs11999515; rs10813806; rs1556138; rs2026739; rs1467712; rs10970971; rs10813813; rs7026133; rs10435797; rs11793098; rs10813818; rs10511906; rs10758139; rs7022554; rs4878497; rs10813815; rs4879583; rs10970978; rs10738886; rs4442231; rs7874815; rs10123372; rs12001953; rs10970965; rs3814520; rs10970975; rs13290492; rs16918276; rs3814521; rs12555576; rs7855113; rs2375965; rs3780474; rs4879584; rs10813816; rs7019520; rs2068116; rs2026740; rs16918256; rs7032871; rs4879586; rs10758138; rs17288067; rs13293491; rs1467713; rs10970972; rs7855756; rs10970977; rs10970980; rs7037425; rs16918278; rs12379278; rs2274721; rs13292540; rs10813811; rs10970969; rs12554703; rs12238573; rs10970976; rs7874563; rs10970966; rs10738887; rs10970973; rs7871750; rs10813817; rs10970974; rs10813814; rs10970964; rs10970981; rs7043497; rs7042042; rs879450; rs867469; rs41304757; rs41305321; rs41306075; rs7025336; rs3814519; rs41313772; rs41272905; rs35706646; rs35610417; rs28445290; rs11789907; rs4324989; rs36073023; rs10970962; rs5897504; rs13294666; rs10970983; rs9721741; rs7040354; rs10970957; rs7027161; rs7049187; rs10970960; rs7033829; rs11424780; rs7049207; rs11318235; rs34173205; rs28667096; rs10758137; rs34758664; rs3085083; rs10970958; rs12338370; rs10713644; rs4634749; rs10758136; rs35547790; rs7020247; rs10970954; rs7854312; rs7847310; rs7031833; rs7851054; rs7018811; rs1064254; rs10970959; rs35241313; rs5897505; rs1136983; rs41314201; rs34915528; rs35631511; rs10970968; rs35495030; rs4492457; rs34268383; rs41298178; rs41272903; rs7868221; rs34178844; rs10970982; rs34617908; rs11315726; rs34256711; rs13283002; rs34533705; rs10970970; rs34070326; rs7035134; rs35294620; rs35429291; rs1136984; rs35503711; rs35639058; rs34738086; rs10123298; rs12350422; rs35612832; rs7046460; rs34888676; rs7859209; rs34715465; rs34941863; rs7863494; rs12350423; rs12003969; rs7469941; rs11282433; rs34854756; rs13288806; rs7875458; rs11421318; rs9695206; rs34680934; rs16918197; rs5023816; rs16918200; rs34115683; rs34176026; rs35460166; rs1023085; rs1023087; rs1052803; rs10738888; rs10738889; rs10738890; rs10758135; rs10813801; rs10813802; rs10813803; rs10970947; rs10970949; rs10970985; rs10970986; rs10970987; rs10970988; rs1133071; rs12006123; rs12236816; rs12237410; rs12551294; rs12555727; rs1360171; rs17288004; rs17288914; rs17289116; rs3205166; rs35210922; rs35253851; rs36046033; rs7044329; rs7047398; rs7857128; rs7865082; rs9792540

# Metabolic_Enzyme_3_General_References:
1738601; 2172968; 1903202; 1946430

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5272

# Metabolic_Enzyme_4_Name:
Citrate synthase, mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
Not Available

# Metabolic_Enzyme_4_Gene_Name:
CS

# Metabolic_Enzyme_4_Protein_Sequence:
>Citrate synthase, mitochondrial precursor
MALLTAAARLLGTKNASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGKTVV
GQITVDMMYG
GMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEGL
FWLLVTGHIPTEEQVSWLSKE
WAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSE
SNFARAYAQGISRTKYWELIYEDSMDLIAKLP
CVAAKIYRNLYREGSGIGAIDSNLDWS
HNFTNMLGYTDHQFTELTRLYLTIHSDHEGGNVSAHTSHLVGS
ALSDPYLSFAAAMNGL
AGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVL
RKTDP
RYTCQREFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMT
EMNYY
TVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDSKSG

# Metabolic_Enzyme_4_Number_of_Residues:
466

# Metabolic_Enzyme_4_Molecular_Weight:
51713

# Metabolic_Enzyme_4_Theoretical_pI:
8.53

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
Function:  citrate (Si)-synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA

# Metabolic_Enzyme_4_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00630  Glyoxylate and dicarboxylate metabolism

# Metabolic_Enzyme_4_Reaction:
acetyl-CoA + H2O + oxaloacetate = citrate + CoA

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00285:Citrate_synt

# Metabolic_Enzyme_4_Signals:
1-16

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.3.3.1

# Metabolic_Enzyme_4_GenBank_ID_Protein:
3288815

# Metabolic_Enzyme_4_SwissProt_ID:
CISY_HUMAN (O75390)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CS

# Metabolic_Enzyme_4_Geneatlas_id:
CS

# Metabolic_Enzyme_4_hgnc_id:
HGNC:2422

# Metabolic_Enzyme_4_PDB_ID:
4CTS

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_4_Gene_Sequence:
>1401 bp

ATGGCTTTACTTACTGCGGCCGCCCGGCTCTTGGGAACCAAGAATGCATCTTGTCTTGT
TCTTGCAGCCC
GGCATGCTAGTGCTTCCTCCACGAATTTGAAAGACATATTGGCTGACC
TGATACCTAAGGAGCAGGCCAG
AATTAAGACTTTCAGGCAGCAACATGGCAAGACGGTG
GTGGGCCAAATCACTGTGGACATGATGTATGGT
GGCATGAGAGGCATGAAGGGATTGGT
GTATGAAACATCAGTTCTTGATCCTGATGAGGGCATCCGTTTCC
GAGGCTTTAGTATCC
CTGAATGCCAGAAACTGCTACCCAAGGCTAAGGGTGGGGAAGAACCCCTGCCTGA
GGGC
TTATTTTGGCTGCTGGTAACTGGATGTATCCCAACAGAGGAACAGGTATCTTGGCTCTCA
AAAGAG
TGGGCAAAGAGGGCAGCTCTGCCTTCCCATGTGGTCACCATGCTGGACAACTT
TCCCACCAATCTACACC
CCATGTCTCAGCTGAGTGCAGCTGTTACAGCCCTCAACAGTG
AAAGTAACTTTGCCCAAGCATATGCACG
GGGTATCAGCCGAACCAAGTACTGGGAGTTG
ATTTATGAAGATTCTGTGGATCTAATAGCAAAGCTACCT
TGTGTTGCAGCAAAGATCTA
CCGAAATCTCTACTGGGAAGGCAGCGGTATTGGGGCCATTGACTCTAACC
TGGACTGGT
CTCACAATTTCACCAACATGTTAGGCTATACTGATCATCAGTTCACTGAGCTCATGCGCC
T
GTACCTCACCATCCACAGTGACCATGAGGGTGGCAATGTAAGTGCCCATACCAGCCAC
TTGGTGGGCAGT
GCCCTTTCCGACCCTTACCTGTCCTTTGCAGCAGCCATGAACGGGCT
GGCAGGGCCTCTCCATGGACTGG
CAAATCAGGAAGTGCTTGTCTGGCTAACACAGCTGC
AGAAGGAAGTTGGCAAAGATGTGTCAGATGAGAA
GTTACGAGACTACATCTGGAACACA
CTCAACTCAGGACGGGTTGTTCCAGGCTATGGCCATGCAGTACTA
AGGAAGACTGATCC
GCGATATACCTGTCAGCGAGAGTTTGCTCTGAAACACCTGCCTAATGACCCCATGT
TTA
AGTTGGTTGCTCAGCTGTACAAGATTGTGCCCAATGTCCTCTTAGAGCAGGGTAAAGCCA
AGAATCC
TTGGCCCAATGTAGATGCTCACAGTGGGGTGCTGCTCCAGTATTATGGCATG
ACGGAGATGAATTACTAC
ACGGTCCTGTTTGGGGTGTCACGAGCATTGGGTGTACTGGC
ACAGCTCATCTGGAGCCGAGCCTTAGGCT
TCCCTCTAGAAAGGCCCAAGTCCATGAGCA
CAGAGGGTCTGATGAAGTTTGTGGACTCTAAGTCAGGGTA
A

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF047042

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_4_Locus:
12q13.2-q13.3

# Metabolic_Enzyme_4_SNPs:
rs1802236; rs2629445; rs6581092; rs1274493; rs2306694; rs4759017; rs2306693; rs11171791; rs3816804; rs2643623; rs11171796; rs3088042; rs703831; rs17118461; rs34457402; rs12818717; rs744051; rs773652; rs17118439; rs773653; rs17118431; rs872103; rs11610449; rs7309201; rs12824674; rs34111839; rs2695789; rs3809127; rs11837305; rs11552472; rs744050; rs12369620; rs28389781; rs11552470; rs1802237; rs1050679; rs28634139; rs2695778; rs12821663; rs11171795; rs34716279; rs35644203; rs28576579; rs2695777; rs2695790; rs10618733; rs2629444; rs12314191; rs34878067; rs11171793; rs12825469; rs12820273; rs34544198; rs11171792; rs10592849; rs11171787; rs34042504; rs36207871; rs34165739; rs12832304; rs12306779; rs10711668; rs2629443; rs2629446; rs12370443; rs34457062; rs11351508; rs2695779; rs11327790; rs11326318; rs11614512; rs35335321; rs35576342; rs34643811; rs33997376; rs35754501; rs35074892; rs7300931; rs28639562; rs35792040; rs34342069; rs11171788; rs3214977; rs3782236; rs12371132; rs35366727; rs11171790; rs10876881; rs41423244; rs5798367; rs813884; rs10656290; rs12825798; rs12826147; rs11614495; rs1045224; rs10783780; rs10876882; rs11543260; rs1274498; rs1274500; rs2293510; rs2450104; rs2695780; rs3184994; rs34026747; rs4354727; rs773651

# Metabolic_Enzyme_4_General_References:
9809442; 12549038

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5713

# Metabolic_Enzyme_5_Name:
Beta-Ala-His dipeptidase precursor

# Metabolic_Enzyme_5_Synonyms:
Carnosine dipeptidase 1; CNDP dipeptidase 1; Serum carnosinase; Glutamate carboxypeptidase-like protein 2

# Metabolic_Enzyme_5_Gene_Name:
CNDP1

# Metabolic_Enzyme_5_Protein_Sequence:
>BetaAlaHis dipeptidase precursor
MDPKLGRMAASLLAVLLLLLERGMFSSPSPPPALLEKVFQYIDLHQDEFVQTLKEWVAIE
SDSVQPVPRFRQELFRMMAVAADTLQRLGARVASVDMGPQQLPDGQSLPIPPVILAELGS
DPTKGTVCFYGHLDVQPADRGDGWLTDPYVLTEVDGKLYGRGATDNKGPVLAWINAVSAF
RALEQDLPVNIKFIIEGMEEAGSVALEELVEKEKDRFFSGVDYIVISDNLWISQRKPAIT
YGTRGNSYFMVEVKCRDQDFHSGTFGGILHEPMADLVALLGSLVDSSGHILVPGIYDEVV
PLTEEEINTYKAIHLDLEEYRNSSRVEKFLFDTKEEILMHLWRYPSLSIHGIEGAFDEPG
TKTVIPGRVIGKFSIRLVPHMNVSAVEKQVTRHLEDVFSKRNSSNKMVVSMTLGLHPWIA
NIDDTQYLAAKRAIRTVFGTEPDMIRDGSTIPIAKMFQEIVHKSVVLIPLGAVDDGEHSQ
NEKINRWNYIEGTKLFAAFFLEMAQLH

# Metabolic_Enzyme_5_Number_of_Residues:
507

# Metabolic_Enzyme_5_Molecular_Weight:
56693

# Metabolic_Enzyme_5_Theoretical_pI:
4.95

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  protein dimerization activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  metallopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_5_Pathway:
map00340  Histidine metabolism;
 map00410  beta-Alanine metabolism

# Metabolic_Enzyme_5_Reaction:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF07687:M20_dimer;
PF01546:Peptidase_M20

# Metabolic_Enzyme_5_Signals:
1-26

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.4.13.20

# Metabolic_Enzyme_5_GenBank_ID_Protein:
16555792

# Metabolic_Enzyme_5_SwissProt_ID:
CNDP1_HUMAN (Q96KN2)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
CNDP1

# Metabolic_Enzyme_5_Geneatlas_id:
CNDP1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:20675

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_5_Gene_Sequence:
>1527 bp
ATGGATCCCAAACTCGGGAGAATGGCTGCGTCCCTGCTGGCTGTGCTGCTGCTGCTGCTG
CTGGAGCGCGGCATGTTCTCCTCACCCTCCCCGCCCCCGGCGCTGTTAGAGAAAGTCTTC
CAGTACATTGACCTCCATCAGGATGAATTTGTGCAGACGCTGAAGGAGTGGGTGGCCATC
GAGAGCGACTCTGTCCAGCCTGTGCCTCGCTTCAGACAAGAGCTCTTCAGAATGATGGCC
GTGGCTGCGGACACGCTGCAGCGCCTGGGGGCCCGTGTGGCCTCGGTGGACATGGGTCCT
CAGCAGCTGCCCGATGGTCAGAGTCTTCCAATACCTCCCGTCATCCTGGCCGAACTGGGG
AGCGATCCCACGAAAGGCACCGTGTGCTTCTACGGCCACTTGGACGTGCAGCCTGCTGAC
CGGGGCGATGGGTGGCTCACGGACCCCTATGTGCTGACGGAGGTAGGCGGGAAACTTTAT
GGACGAGGAGCGACCGACAACAAAGGCCCTGTCTTGGCTTGGATCAATGCTGTGAGCGCC
TTCAGAGCCCTGGAGCAAGATCTTCCTGTGAATATCAAATTCATCATTGAGGGGATGGAA
GAGGCTGGCTCTGTTGCCCTGGAGGAACTTGTGGAAAAAGAAAAGGACCGATTCTTCTCT
GGTGTGGACTACATTGTAATTTCAGATAACCTGTGGATCAGCCAAAGGAAGCTAGCAATC
ACTTACGGAACCCGGGGGAACAGCTACTTCATGGTGGAGGTGAAATGCAGAGACCAGGAT
TTTCACTCAGGAACCTTTGGTGGCATCCTTCATGAACTAATGGCTGATCTGGTTGCTCTT
CTCGGTAGCCTGGTAGACTCGTCTGGTCATATCCTGGTCCCTGGAATCTATGATGAAGTG
GTTCCTCTTACAGAAGAGGAAATAAATACATACAAAGCCATCCATCTAGACCTAGAAGAA
TACCGGAATAGCAGCCGGGTTGAGAAATTTCTGTTCGATACTAAGGAGGAGATTCTAATG
CACCTCTGGAGGTACCCATCTCTTTCTATTCATGGGATCGAGGGCGCGTTTGATGAGCCT
GGAACTAAAACAGTCATACCTGGCCGAGTTATAGGAAAATTTTCAATCCGTCTAGTCCCT
CACATGAATGTGTCTGCGGTGGAAAAACAGGTGACACGACATCTTGAAGATGTGTTCTCC
AAAAGAAATAGTTCCAACAAGATGGTTGTTTCCATGACTCTAGGACTACACCCGTGGATT
GCAAATATTGATGACACTCAGTATCTCGCAGCAAAAAGAGCGATCAGAACAGTGTTTGGA
ACAGAACCAGATATGATCCGGGATGGATCCACCATTCCAATTGCCAAAATGTTCCAGGAG
ATCGTCCACAAGAGCGTGGTGCTAATTCCGCTGGGAGCTGTTGATGATGGAGAACATTCG
CAGAATGAGAAAATCAACAGGTGGAACTACATAGAGGGAACCAAATTATTTGCTGCCTTT
TTCTTAGAGATGGCCCAGCTCCATTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AJ417564

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:18

# Metabolic_Enzyme_5_Locus:
18q22.3

# Metabolic_Enzyme_5_SNPs:
rs4263028; rs11151964; rs9807352; rs12960862; rs2887; rs4891564; rs2346064; rs1004453; rs7239132; rs12604675; rs10469123; rs10469203; rs12607796; rs12605490; rs8087768; rs9319909; rs4892246; rs7506171; rs4329999; rs7242384; rs8085167; rs11876996; rs7244370; rs7506929; rs4892243; rs7231312; rs4892242; rs12605520; rs733686; rs9967490; rs7229005; rs7232853; rs1426256; rs7506957; rs17817095; rs11875756; rs7506825; rs17817180; rs12961730; rs12964027; rs12456406; rs12964208; rs7506760; rs12956997; rs12456388; rs12964454; rs11873844; rs17817345; rs7505047; rs17089382; rs17089414; rs17089390; rs7233066; rs9953129; rs9960024; rs11659237; rs9807248; rs11662276; rs17816861; rs11873901; rs10469124; rs17089403; rs1559809; rs17817077; rs9949100; rs4891563; rs11661606; rs2881289; rs7228575; rs9957229; rs9955944; rs17089375; rs4892244; rs17089411; rs4892239; rs17238585; rs7505555; rs12326826; rs9946796; rs11876764; rs9949990; rs34570315; rs12957330; rs7506936; rs4892241; rs7506258; rs9952652; rs4355018; rs9957885; rs11664748; rs4133234; rs17238285; rs1974965; rs11659364; rs4892238; rs11875122; rs7237549; rs9948919; rs12959707; rs12457983; rs12964810; rs1974963; rs4891562; rs11873542; rs12962343; rs2881288; rs17089378; rs12954161; rs9959794; rs7504932; rs12327522; rs11664535; rs7230673; rs12455650; rs1974964; rs7244647; rs9989559; rs11875810; rs12954438; rs2098910; rs2346061; rs2346063; rs890333; rs2346062; rs2081548; rs890332; rs11538620; rs34522443; rs11538622; rs11538624; rs11538623; rs35604255; rs10533212; rs35771415; rs34713611; rs9967349; rs33922160; rs34365714; rs34526667; rs11875787; rs28448542; rs28871039; rs35084313; rs10549931; rs10685765; rs34874693; rs4891561; rs12606902; rs34117300; rs12959038; rs36228963; rs5826336; rs35735348; rs34499247; rs35885130; rs35388041; rs28713380; rs11151965; rs34138697; rs35204551; rs9966983; rs7505007; rs35096494; rs33950634; rs33981863; rs34142328; rs12959706; rs9955580; rs9947243; rs34869467; rs35788286; rs10624462; rs34283867; rs6566813; rs34962477; rs34335073; rs5826332; rs36060345; rs34573470; rs35682790; rs35362460; rs35860275; rs35365788; rs12964034; rs10522670; rs12959748; rs4892245; rs36111704; rs12969794; rs5826335; rs4891560; rs9965945; rs34070364; rs10624665; rs5826334; rs34842524; rs35877440; rs34785330; rs17089373; rs7233122; rs10596720; rs9948674; rs34189472; rs10562152; rs10649703; rs34321505; rs35707511; rs9949211; rs35368997; rs35691581; rs35734110; rs9953867; rs34563384; rs35469246; rs8087111; rs34726849; rs35932028; rs12969795; rs12969769; rs34799288; rs35234907; rs28800835; rs34646410; rs10685766; rs34895018; rs35597919; rs12961586; rs6566814; rs28877095; rs4892240; rs33911381; rs8088199; rs11872770; rs36206459; rs7350982; rs34145828; rs11447097; rs12104001; rs4892247; rs3080879; rs10663835; rs10871736; rs10871737; rs1130046; rs11664131; rs12327049; rs12456405; rs12954579; rs12966495; rs12967519; rs12970020; rs17089369; rs2114228; rs28534519; rs35248661; rs4353545; rs4891565; rs4891566; rs4892233; rs4892248; rs4892249; rs6566815; rs7238101; rs7504377; rs7506051; rs7506112; rs8096427; rs8099458; rs9319908

# Metabolic_Enzyme_5_General_References:
12975309

# Metabolic_Enzyme_5_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
5922

# Macromolecular_Interacting_Partner_1_Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4A

# Macromolecular_Interacting_Partner_1_Synonyms:
DPDE2; PDE46

# Macromolecular_Interacting_Partner_1_Gene_Name:
PDE4A

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>cAMPspecific 3',5'cyclic phosphodiesterase 4
AMEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERER
QPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPG
RSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVT
PFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELD
WCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVE
IPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKT
DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM
LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG
VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVID
MVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPL
ELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD
LVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE
EISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYL
TQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGL
PSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
886

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
98144

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
4.87

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate

# Macromolecular_Interacting_Partner_1_Pathway:
map00230  Purine metabolism

# Macromolecular_Interacting_Partner_1_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00233:PDEase_I

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 3.1.4.17

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
347120

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
PDE4A_HUMAN (P27815)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
PDE4A

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
PDE4A

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:8780

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Isoform 4:Membrane; peripheral membrane protein. Note=Isoform 4 has propensity for association with membranes

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>2661 bp
ATGGAACCCCCGACCGTCCCCTCGGAAAGGAGCCTGTCTCTGTCACTGCCCGGGCCCCGG
GAGGGCCAGGCCACCCTGAAGCCTCCCCCGCAGCACCTGTGGCGGCAGCCTCGGACCCCC
ATCCGTATCCAGCAGCGCGGCTACTCCGACAGCGCGGAGCGCGCCGAGCGGGAGCGGCAG
CCGCACCGGCCCATAGAGCGCGCCGATGCCATGGACACCAGCGACCGGCCCGGCCTGCGC
ACGACCCGCATGTCCTGGCCCTCGTCCTTCCATGGCACTGGCACCGGCAGCGGCGGCGCG
GGCGGAGGCAGCAGCAGGCGCTTCGAGGCAGAGAATGGGCCGACACCATCTCCTGGCCGC
AGCCCCCTGGACTCGCAGGCGAGCCCAGGACTCGTGCTGCACGCCGGGGCGGCCACCAGC
CAGCGCCGGGAGTCCTTCCTGTACCGCTCAGACAGCGACTATGACATGTCACCCAAGACC
ATGTCCCGGAACTCATCGGTCACCAGCGAGGCGCACGCTGAAGACCTCATCGTAACACCA
TTTGCTCAGGTGCTGGCCAGCCTCCGGAGCGTCCGTAGCAACTTCTCACTCCTGACCAAT
GTGCCCGTTCCCAGTAACAAGCGGTCCCCGCTGGGCGGCCCCACCCCTGTCTGCAAGGCC
ACGCTGTCAGAAGAAACGTGTCAGCAGTTGGCCCGGGAGACTCTGGAGGAGCTGGACTGG
TGTCTGGAGCAGCTGGAGACCATGCAGACCTATCGCTCTGTCAGCGAGATGGCCTCGCAC
AAGTTCAAAAGGATGTTGAACCGTGAGCTCACACACCTGTCAGAAATGAGCAGGTCCGGA
AACCAGGTCTCAGAGTACATTTCCACAACATTCCTGGACAAACAGAATGAAGTGGAGATC
CCATCACCCACGATGAAGGAACGAGAAAAACAGCAAGCGCCGCGACCAAGACCCTCCCAG
CCGCCCCCGCCCCCTGTACCACACTTACAGCCCATGTCCCAAATCACAGGGTTGAAAAAG
TTGATGCATAGTAACAGCCTGAACAACTCTAACATTCCCCGATTTGGGGTGAAGACCGAT
CAAGAAGAGCTCCTGGCCCAAGAACTGGAGAACCTGAACAAGTGGGGCCTGAACATCTTT
TGCGTGTCGGATTACGCTGGAGGCCGCTCACTCACCTGCATCATGTACATGATATTCCAG
GAGCGGGACCTGCTGAAGAAATTCCGCATCCCGGTGGACACGATGGTGACATACATGCTG
ACGCTGGAGGATCACTACCACGCTGACGTGGCCTACCATAACAGCCTGCACGCAGCTGAC
GTGCTGCAGTCCACCCACGTACTGCTGGCCACGCCTGCACTAGATGCAGTGTTCACGGAC
CTGGAGATTCTCGCCGCCCTCTTCGCGGCTGCCATCCACGATGTGGATCACCCTGGGGTC
TCCAACCAGTTCCTCATCAACACCAATTCGGAGCTGGCGCTCATGTACAACGATGAGTCG
GTGCTCGAGAATCACCACCTGGCCGTGGGCTTCAAGCTGCTGCAGGAGGACAACTGCGAC
ATCTTCCAGAACCTCAGCAAGCGCCAGCGGCAGAGCCTACGCAAGATGGTCATCGACATG
GTGCTGGCCACGGACATGTCCAAGCACATGACCCTCCTGGCTGACCTGAAGACCATGGTG
GAGACCAAGAAAGTGACCAGCTCAGGGGTCCTCCTGCTAGATAACTACTCCGACCGCATC
CAGGTCCTCCGGAACATGGTGCACTGTGCCGACCTCAGCAACCCCACCAAGCCGCTGGAG
CTGTACCGCCAGTGGACAGACCGCATCATGGCCGAGTTCTTCCAGCAGGGTGACCGAGAG
CGCGAGCGTGGCATGGAAATCAGCCCCATGTGTGACAAGCACACTGCCTCCGTGGAGAAG
TCTCAGGTGGGTTTTATTGACTACATTGTGCACCCATTGTGGGAGACCTGGGCGGACCTT
GTCCACCCAGATGCCCAGGAGATCTTGGACACTTTGGAGGACAACCGGGACTGGTACTAC
AGCGCCATCCGGCAGAGCCCATCTCCGCCACCCGAGGAGGAGTCAAGGGGGCCAGGCCAC
CCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGAA
ATATCAATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCA
GGAGTCGAGGAAGCTCTGGATGCAACCATAGCCTGGGAGGCATCCCCGGCCCAGGAGTCG
TTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGACA
CAGCAGGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAG
GAATTCGTGGTTGCTGTAAGCCACAGCAGCCCCTCTGCCCTGGCTCTTCAAAGCCCCCTT
CTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCCC
TCCACGGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGT
GCCTGCGCAGGGACATTTGGGGAGGACACATCCGCACTCCCAGCTCCTGGTGGCGGGGGG
TCAGGTGGAGACCCTACCTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
L20965

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_1_Locus:
19p13.2

# Macromolecular_Interacting_Partner_1_SNPs:
rs1051738; rs2230190; rs2230189; rs7256672; rs3745258; rs4804134; rs2358681; rs10416143; rs7247481; rs7343073; rs1194098; rs11672021; rs1051736; rs3192116; rs35473931; rs35610871; rs3745260; rs3192124; rs3833220; rs7253115; rs12985883; rs3745259; rs34212445; rs2569755; rs35371416; rs12983959; rs2569756; rs2735389; rs5827100; rs11666164; rs10404367; rs12975524; rs34214178; rs35888394; rs10411816; rs34675916; rs12610073; rs35398762; rs34222169; rs33984348; rs34278258; rs35452057; rs12975511; rs34861232; rs12981823; rs12982685; rs1194097; rs4804504; rs35757023; rs12982917; rs35214617; rs34230915; rs4804503; rs35368894; rs12981546; rs12975530; rs3936362; rs35867809; rs2735390; rs10423080; rs2569758; rs2569765; rs12978292; rs2569766; rs12978315; rs2569757; rs2569763; rs12978301; rs2569759; rs2569761; rs12978366; rs2569764; rs2569762; rs12978582; rs2569760; rs12980133; rs35084366; rs12980191; rs12981218; rs35715070; rs34519818; rs35937838; rs10416653; rs11671269; rs2569767; rs2569768; rs4804505; rs8105602

# Macromolecular_Interacting_Partner_1_General_References:
8413254; 9677330; 2160582; 7772058; 7888306

# Macromolecular_Interacting_Partner_1_References:
17017975

# Macromolecular_Interacting_Partner_2_ID:
7671

# Macromolecular_Interacting_Partner_2_Name:
Alpha-S1-casein precursor [Contains: Casoxin-D]

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
CSN1S1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>AlphaS1casein precursor Contains: Casoxin
DMRLLILTCLVAVALARPKLPLRYPERLQNPSESSEPIPLESREEYMNGMNRQRNILREK
QTDEIKDTRNESTQNCVVAEPEKMESSISSSSEEMSLSKCAEQFCRLNEYNQLQLQAAHA
QEQIRRMNENSHVQVPFQQLNQLAAYPYAVWYYPQIMQYVPFPPFSDISNPTAHENYEKN
NVMLQW

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
185

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
21672

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.08

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Signals:
1-15

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
854086

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
CASA1_HUMAN (P47710)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
CSN1S1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
CSN1S1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:2445

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>558 bp
ATGAGGCTTCTCATTCTCACCTGTCTTGTGGCTGTTGCTCTTGCCAGGCCTAAACTTCCT
CTTAGATACCCAGAACGCCTTCAGAATCCATCAGAGAGCAGTGAGCCTATACCATTAGAA
TCAAGAGAGGAATACATGAATGGTATGAACAGGCAGAGAAACATTCTGAGAGAAAAACAG
ACTGATGAAATCAAGGATACTAGGAATGAGTCTACTCAGAACTGTGTTGTGGCAGAGCCT
GAGAAGATGGAATCCAGCATCAGTTCATCGAGTGAGGAAATGTCTCTCAGTAAGTGTGCG
GAACAGTTTTGTAGACTGAACGAATACAACCAACTTCAGCTGCAAGCTGCCCATGCCCAG
GAGCAAATTCGCAGAATGAATGAAAACAGCCATGTCCAAGTGCCTTTCCAGCAGCTCAAC
CAACTTGCTGCCTACCCCTATGCTGTTTGGTACTATCCACAAATCATGCAGTATGTTCCT
TTCCCACCGTTTTCCGACATCTCCAATCCCACTGCTCATGAAAATTATGAAAAAAATAAC
GTCATGCTACAGTGGTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
X78416

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_2_Locus:
4q21.1

# Macromolecular_Interacting_Partner_2_SNPs:
rs10030475; rs1237375; rs2291531; rs2306995; rs1220853; rs2029572; rs17146477; rs1388353; rs1220860; rs1220858; rs1220859; rs2279526; rs17629671; rs2637803; rs9994880; rs3775766; rs1231466; rs17146476; rs2306994; rs12499547; rs17696920; rs17146475; rs10022914; rs10024477; rs12503280; rs1529038; rs1220854; rs1220841; rs1220842; rs17696835; rs1220843; rs34698344; rs35936840; rs28563121; rs10029240; rs962689; rs6148504; rs34493157; rs13115383; rs35000195; rs28633589; rs7436100; rs10002549; rs36026498; rs3736267; rs3736268; rs34713531; rs9992853; rs34572389; rs28388277; rs35005404; rs28633873; rs1220857; rs3822170; rs2877505; rs12499478; rs33928842; rs10028221; rs36213128; rs2222793; rs10026137; rs5859206; rs3756137; rs3078677; rs34788552; rs10032658; rs9994675; rs5859205; rs1220855; rs10011226; rs34898191; rs28592911; rs5859204; rs1220856; rs10030869; rs10030691; rs33916414; rs28478637; rs9998575; rs10009308; rs28583244; rs10008887; rs10017650; rs10020367; rs1002081; rs1002082; rs10155315; rs1220849; rs1220861; rs1220862; rs13113735; rs1388354; rs1491429; rs1491430; rs17147885; rs17697310; rs1844828; rs1919597; rs2331853; rs2637815; rs2637816; rs2734570; rs4568298; rs4694257; rs7680177; rs9654357; rs9884504; rs999694

# Macromolecular_Interacting_Partner_2_General_References:
7619062; 7749638; 9050925

# Macromolecular_Interacting_Partner_2_References:
16025219; 16702255

# Macromolecular_Interacting_Partner_3_ID:
7719

# Macromolecular_Interacting_Partner_3_Name:
Transient receptor potential cation channel subfamily V member 1

# Macromolecular_Interacting_Partner_3_Synonyms:
TrpV1; osm-9-like TRP channel 1; OTRPC1; Vanilloid receptor 1; Capsaicin receptor

# Macromolecular_Interacting_Partner_3_Gene_Name:
TRPV1

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Transient receptor potential cation channel subfamily V member 1
MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP
VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE
AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI
ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT
KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA
DNTKFVTSMYNEILILGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE
PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN
RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL
SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS
MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE
DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF
IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA
FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS
SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
839

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
94939

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
7.26

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  transporter activity
Function:  ion transporter activity
Function:  ion channel activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
 ||
>>>
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00023:Ank;
PF00520:Ion_trans

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
434-454
477-497
514-534
536-556
580-600
660-680

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
8977866

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
TRPV1_HUMAN (Q8NER1)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
TRPV1

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
TRPV1

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:12716

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cell membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>2520 bp
ATGAAGAAATGGAGCAGCACAGACTTGGGGGCAGCTGCGGACCCACTCCAAAAGGACACC
TGCCCAGACCCCCTGGATGGAGACCCTAACTCCAGGCCACCTCCAGCCAAGCCCCAGCTC
TCCACGGCCAAGAGCCGCACCCGGCTCTTTGGGAAGGGTGACTCGGAGGAGGCTTTCCCG
GTGGATTGCCCTCACGAGGAAGGTGAGCTGGACTCCTGCCCGACCATCACAGTCAGCCCT
GTTATCACCATCCAGAGGCCAGGAGACGGCCCCACCGGTGCCAGGCTGCTGTCCCAGGAC
TCTGTCGCCGCCAGCACCGAGAAGACCCTCAGGCTCTATGATCGCAGGAGTATCTTTGAA
GCCGTTGCTCAGAATAACTGCCAGGATCTGGAGAGCCTGCTGCTCTTCCTGCAGAAGAGC
AAGAAGCACCTCACAGACAACGAGTTCAAAGACCCTGAGACAGGGAAGACCTGTCTGCTG
AAAGCCATGCTCAACCTGCACGACGGACAGAACACCACCATCCCCCTGCTCCTGGAGATC
GCGCGGCAAACGGACAGCCTGAAGGAGCTTGTCAACGCCAGCTACACGGACAGCTACTAC
AAGGGCCAGACAGCACTGCACATCGCCATCGAGAGACGCAACATGGCCCTGGTGACCCTC
CTGGTGGAGAACGGAGCAGACGTCCAGGCTGCGGCCCATGGGGACTTCTTTAAGAAAACC
AAAGGGCGGCCTGGATTCTACTTCGGTGAACTGCCCCTGTCCCTGGCCGCGTGCACCAAC
CAGCTGGGCATCGTGAAGTTCCTGCTGCAGAACTCCTGGCAGACGGCCGACATCAGCGCC
AGGGACTCGGTGGGCAACACGGTGCTGCACGCCCTGGTGGAGGTGGCCGACAACACGGCC
GACAACACGAAGTTTGTGACGAGCATGTACAATGAGATTCTGATCCTGGGGGCCAAACTG
CACCCGACGCTGAAGCTGGAGGAGCTCACCAACAAGAAGGGAATGACGCCGCTGGCTCTG
GCAGCTGGGACCGGGAAGATCGGGGTCTTGGCCTATATTCTCCAGCGGGAGATCCAGGAG
CCCGAGTGCAGGCACCTGTCCAGGAAGTTCACCGAGTGGGCCTACGGGCCCGTGCACTCC
TCGCTGTACGACCTGTCCTGCATCGACACCTGCGAGAAGAACTCGGTGCTGGAGGTGATC
GCCTACAGCAGCAGCGAGACCCCTAATCGCCACGACATGCTCTTGGTGGAGCCGCTGAAC
CGACTCCTGCAGGACAAGTGGGACAGATTCGTCAAGCGCATCTTCTACTTCAACTTCCTG
GTCTACTGCCTGTACATGATCATCTTCACCATGGCTGCCTACTACAGGCCCGTGGATGGC
TTGCCTCCCTTTAAGATGGAAAAAACTGGAGACTATTTCCGAGTTACTGGAGAGATCCTG
TCTGTGTTAGGAGGAGTCTACTTCTTTTTCCGAGGGATTCAGTATTTCCTGCAGAGGCGG
CCGTCGATGAAGACCCTGTTTGTGGACAGCTACAGTGAGATGCTTTTCTTTCTGCAGTCA
CTGTTCATGCTGGCCACCGTGGTGCTGTACTTCAGCCACCTCAAGGAGTATGTGGCTTCC
ATGGTATTCTCCCTGGCCTTGGGCTGGACCAACATGCTCTACTACACCCGCGGTTTCCAG
CAGATGGGCATCTATGCCGTCATGATAGAGAAGATGATCCTGAGAGACCTGTGCCGTTTC
ATGTTTGTCTACGTCGTCTTCTTGTTCGGGTTTTCCACAGCGGTGGTGACGCTGATTGAA
GACGGGAAGAATGACTCCCTGCCGTCTGAGTCCACGTCGCACAGGTGGCGGGGGCCTGCC
TGCAGGCCCCCCGATAGCTCCTACAACAGCCTGTACTCCACCTGCCTGGAGCTGTTCAAG
TTCACCATCGGCATGGGCGACCTGGAGTTCACTGAGAACTATGACTTCAAGGCTGTCTTC
ATCATCCTGCTGCTGGCCTATGTAATTCTCACCTACATCCTCCTGCTCAACATGCTCATC
GCCCTCATGGGTGAGACTGTCAACAAGATCGCACAGGAGAGCAAGAACATCTGGAAGCTG
CAGAGAGCCATCACCATCCTGGACACGGAGAAGAGCTTCCTTAAGTGCATGAGGAAGGCC
TTCCGCTCAGGCAAGCTGCTGCAGGTGGGGTACACACCTGATGGCAAGGACGACTACCGG
TGGTGCTTCAGGGTGGACGAGGTGAACTGGACCACCTGGAACACCAACGTGGGCATCATC
AACGAAGACCCGGGCAACTGTGAGGGCGTCAAGCGCACCCTGAGCTTCTCCCTGCGGTCA
AGCAGAGTTTCAGGCAGACACTGGAAGAACTTTGCCCTGGTCCCCCTTTTAAGAGAGGCA
AGTGCTCGAGATAGGCAGTCTGCTCAGCCCGAGGAAGTTTATCTGCGACAGTTTTCAGGG
TCTCTGAAGCCAGAGGACGCTGAGGTCTTCAAGAGTCCTGCCGCTTCCGGGGAGAAGTGA


# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AJ277028

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_3_Locus:
17p13.3

# Macromolecular_Interacting_Partner_3_SNPs:
rs161382; rs182637; rs1018186; rs1018187; rs222741; rs7214357; rs733080; rs4790522; rs9895612; rs222738; rs11870382; rs3744685; rs11867691; rs2277675; rs10491215; rs161377; rs1566790; rs4790521; rs392574; rs17707155; rs7217945; rs414742; rs10491214; rs10438717; rs161383; rs7209050; rs1018188; rs11870416; rs17634022; rs222740; rs161385; rs161372; rs161381; rs161376; rs222750; rs161384; rs7211517; rs222742; rs12944357; rs161375; rs16953295; rs161380; rs161379; rs16942458; rs729271; rs3744684; rs150845; rs161374; rs12601809; rs161373; rs161378; rs3786033; rs7217950; rs16953227; rs1976481; rs11869034; rs10438718; rs222747; rs877611; rs224547; rs224536; rs224535; rs224546; rs161393; rs224522; rs161386; rs150908; rs224534; rs877610; rs161394; rs222746; rs8065080; rs161364; rs222748; rs9902581; rs224549; rs150846; rs161365; rs2277676; rs161366; rs7502670; rs224555; rs12936340; rs224537; rs16953163; rs224551; rs2318102; rs17706630; rs17633288; rs9902155; rs222749; rs222745; rs8078936; rs7502141; rs7220415; rs4790523; rs11655540; rs10445287; rs224550; rs669092; rs224530; rs877612; rs161392; rs8078502; rs34378673; rs1801682; rs3744686; rs224523; rs2063136; rs3826501; rs161391; rs3826503; rs4790151; rs161389; rs224519; rs17632971; rs11657738; rs16953199; rs2277679; rs17706245; rs224553; rs11650520; rs224521; rs12947520; rs224520; rs161387; rs224548; rs222744; rs8079973; rs4790525; rs17632843; rs4790524; rs7223530; rs7503066; rs11078460; rs4790150; rs6502734; rs7406509; rs9908967; rs2737140; rs34662119; rs172750; rs34203267; rs222743; rs11388394; rs7211511; rs35151317; rs465484; rs28676532; rs1136959; rs167739; rs1141893; rs402369; rs12602895; rs34587120; rs460211; rs9899485; rs34306285; rs1136961; rs12942886; rs35408484; rs9900231; rs3837858; rs457454; rs3039653; rs35646616; rs34701684; rs170312; rs1136960; rs2017871; rs35309728; rs35075293; rs222739; rs3039673; rs34173118; rs431260; rs11871319; rs34144715; rs12937864; rs4990587; rs34670235; rs161395; rs35935447; rs35543801; rs9913209; rs9912952; rs10445288; rs34827170; rs11353581; rs435428; rs3216758; rs34374669; rs150915; rs224527; rs35822717; rs12947515; rs34330693; rs28767203; rs34886402; rs224526; rs16953166; rs36150459; rs224552; rs415955; rs2456855; rs11390232; rs2277678; rs421140; rs2277677; rs9894618; rs11441416; rs224529; rs35443828; rs41438645; rs12947505; rs12945340; rs35206227; rs35123560; rs224528; rs161390; rs11441417; rs2318103; rs520671; rs184411; rs5818901; rs35006948; rs34087976; rs455011; rs12600675; rs465588; rs35246256; rs3837860; rs222782; rs11870901; rs5818900; rs224524; rs35854654; rs34771586; rs457481; rs224532; rs35542678; rs35661231; rs161363; rs2940185; rs9912962; rs161388; rs9890572; rs28446709; rs35995351; rs11271477; rs10445260; rs224525; rs35097262; rs422229; rs35546905; rs35095034; rs224533; rs35070196; rs224554; rs11454994; rs224531; rs34777471; rs172751; rs35781190; rs224538; rs12949222; rs11658214; rs11400955; rs35758169; rs7222725; rs161396; rs35166148; rs3837859; rs11870284; rs379156; rs10609559; rs10560490; rs10609560; rs9908215; rs380428; rs9910514; rs34635835; rs378271; rs11870904; rs12602970; rs150854; rs16942462; rs16953301; rs1977021; rs222780; rs224495; rs224496; rs224498; rs2737141; rs322957; rs322958; rs322960; rs322962; rs322963; rs35091524; rs36125540; rs3744681; rs3744683; rs460716; rs465563; rs4790520; rs6502736; rs8070980; rs8076578; rs8076728; rs8077255; rs8077963; rs8079139; rs8082595; rs8082676; rs879207; rs9899882; rs9906287

# Macromolecular_Interacting_Partner_3_General_References:
11050376; 11226139; 11230166; 12077606

# Macromolecular_Interacting_Partner_3_References:
16627674; 16914432

# Macromolecular_Interacting_Partner_4_ID:
8473

# Macromolecular_Interacting_Partner_4_Name:
Hypothetical protein DKFZp686E17257

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
DKFZp686E17257

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Hypothetical protein DKFZp686E17257
FAWLWLQFVYMRFNFKKSWGCGLESKKNEKAALKVLQEEYRKLGPLSFAEINVLICFFLL
VILWFSRDPGFMPGWLTVAWVEGETKYVSDATVAIFVATLLFIVPSQKPKFNFRSQTEEE
RKTPFYPPPLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPA
AITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNPLYIMLPCTLSASFAFMLPV
ATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIFDLDHFPDWANVTHI
ET

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
302

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
33817

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.20

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
 Function:  transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  cation transport
Process:  monovalent inorganic cation transport
Process:  sodium ion transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Inorganic ion transport and metabolism

# Macromolecular_Interacting_Partner_4_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00939:Na_sulph_symp

# Macromolecular_Interacting_Partner_4_Signals:
1-20

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
43-65; 87-104; 144-166; 176-198; 219-241; 256-278

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
51476832

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
Q68D44_HUMAN (Q68D44)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
DKFZp686E17257

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
DKFZp686E17257

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:23089

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>909 bp
TTCGCCTGGCTGTGGCTCCAGTTTGTTTACATGAGATTCAATTTTAAAAAGTCCTGGGGC
TGCGGGCTAGAGAGCAAGAAAAACGAGAAGGCTGCCCTCAAGGTGCTGCAGGAGGAGTAC
CGGAAGCTGGGGCCCTTGTCCTTCGCGGAGATCAACGTGCTGATCTGCTTCTTCCTGCTG
GTCATCCTGTGGTTCTCCCGAGACCCCGGCTTCATGCCCGGCTGGCTGACTGTTGCCTGG
GTGGAGGGTGAGACAAAGTATGTCTCCGATGCCACTGTGGCCATCTTTGTGGCCACCCTG
CTATTCATTGTGCCTTCACAGAAGCCCAAGTTTAACTTCCGCAGCCAGACTGAGGAAGAA
AGGAAAACTCCATTTTATCCCCCTCCCCTGCTGGATTGGAAGGTAACCCAGGAGAAAGTG
CCCTGGGGCATCGTGCTGCTACTAGGGGGCGGATTTGCTCTGGCTAAAGGATCCGAGGCC
TCGGGGCTGTCCGTGTGGATGGGGAAGCAGATGGAGCCCTTGCACGCAGTGCCCCCGGCA
GCCATCACCTTGATCTTGTCCTTGCTCGTTGCCGTGTTCACTGAGTGCACAAGCAACGTG
GCCACCACCACCTTGTTCCTGCCCATCTTTGCCTCCATGTCTCGCTCCATCGGCCTCAAT
CCGCTGTACATCATGCTGCCCTGTACCCTGAGTGCCTCCTTTGCCTTCATGTTGCCTGTG
GCCACCCCTCCAAATGCCATCGTGTTCACCTATGGGCACCTCAAGGTTGCTGACATGGTG
AAAACAGGAGTCATAATGAACATAATTGGAGTCTTCTGTGTGTTTTTGGCTGTCAACACC
TGGGGACGGGCCATATTTGACTTGGATCATTTCCCTGACTGGGCTAATGTGACACATATT
GAGACTTAG

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
CR749584

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_4_Locus:
Not Available

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
Not Available

# Macromolecular_Interacting_Partner_4_References:
Not Available

# Macromolecular_Interacting_Partner_5_ID:
8605

# Macromolecular_Interacting_Partner_5_Name:
Citrate lyase beta like

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
CLYBL

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Citrate lyase beta like
LQAIDLVYIDFRDGAGLLRQSREGAAMGFTGKQVIHPNQIAVVQEQFSPSPEKIKWAEEL
IAAFKEHQQLGKGAFTFQGSMIDMPLLKQAQNTVTLATSIKEK

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
103

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
11401

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
7.70

# Macromolecular_Interacting_Partner_5_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_5_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF03328:HpcH_HpaI

# Macromolecular_Interacting_Partner_5_Signals:
Not Available

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
57160623

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
Q5JVC0_HUMAN (Q5JVC0)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
CLYBL

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
CLYBL

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:18355

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>961 bp
GAAAGCGTCTCTAGCAGCTGATATCCCCAGACTTGGATATAGTTCCTCATCCCATCACAA
GTACATCCCCCGGAGGGCAGTGCTTTATGTACCTGGAAATGATGAAAAGAAAATAAAGAA
GATTCCATCCCTGAATGTAGATTGTGCAGTGCTCGACTGTGAGGATGGAGTGGCTGCAAA
CAAAAAGAATGAAGCTCGACTGAGAATTGTAAAAACTCTTGAAGACATTGATCTGGGCCC
TACTGAAAAATGTGTGAGAGTCAACTCAGTTTCCAGTGGTCTGGCGGAAGAAGACCTAGA
GACCCTTTTGCAATCCCGGGTCCTTCCTTCCAGCCTGATGCTACCAAAGGTGGAAAGTCC
TGAAGAAATCCAGTGGTTTGCAGACAAATTTTCATTCCACTTAAAAGGCCGAAAACTTGA
ACAACCAATGAATTTAATCCCTTTTGTGGAAACTGCAATGGGTTTGCTCAATTTTAAGGC
AGTGTGTGAAGAAACCCTGAAGGTCGGGCCTCAAGTAGGTCTCTTTCTAGATGCAGTCGT
TTTTGGAGGAGAAGACTTTCGAGCCAGCATAGGTGCAACAAGTAGTAAAGAAACCCTGGA
TATTCTCTACGCCCGGCAAAAGATTGTTGTCATAGCGAAAGCCTTTGGTCTCCAAGCCAT
AGATCTGGTGTACATTGACTTTCGAGATGGAGCTGGGCTGCTTAGACAGTCACGAGAAGG
AGCCGCCATGGGCTTCACTGGTAAGCAGGTGATTCACCCTAACCAAATTGCCGTGGTCCA
GGAGCAGTTTTCTCCTTCCCCTGAAAAAATTAAGTGGGCTGAAGAACTGATTGCTGCCTT
TAAAGAACATCAACAATTAGGAAAGGGGGCCTTTACTTTCCAAGGGAGTATGATCGACAT
GCCATTACTGAAGCAGGCCCAGAACACTGTTACGCTTGCCACCTCCATCAAGGAAAAATG
A

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AL137139

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:13

# Macromolecular_Interacting_Partner_5_Locus:
13q32

# Macromolecular_Interacting_Partner_5_SNPs:
rs3783185; rs17577293; rs35680839; rs1924104; rs11617041; rs2281757; rs8002438; rs7997714; rs12019809; rs9300573; rs2281756; rs12584825; rs1886033; rs9513680; rs7333559; rs9557330; rs6491538; rs2296117; rs7992643; rs7318415; rs7998712; rs7331251; rs11616403; rs12323012; rs6491539; rs9582352; rs1040997; rs9554647; rs7318038; rs12018767; rs7317993; rs2281755; rs7992592; rs9517908; rs9554648; rs9585264; rs6491536; rs2038695; rs9585263; rs11842450; rs9557333; rs1924105; rs6491537; rs7322872; rs7994827; rs2763950; rs725834; rs2039933; rs2793762; rs2763947; rs2761153; rs2057490; rs912284; rs1886031; rs1886035; rs2793760; rs912288; rs2763948; rs2038693; rs968535; rs2057489; rs912290; rs2390323; rs2761174; rs1028710; rs2806280; rs2806285; rs1000022; rs2793745; rs1886034; rs6491526; rs9554619; rs754003; rs2806295; rs9300571; rs2806281; rs912285; rs9585198; rs2806284; rs12866973; rs12184508; rs9557276; rs11838894; rs7328481; rs9554641; rs2761156; rs9517818; rs2793761; rs2761169; rs9557286; rs912289; rs1105576; rs9554620; rs6491534; rs7993372; rs2793749; rs12430063; rs4772245; rs2806290; rs7333752; rs7336903; rs3742254; rs8002555; rs4772238; rs2806283; rs9517847; rs1924099; rs2761163; rs2763940; rs754004; rs10775026; rs7984263; rs7994744; rs11069375; rs4592516; rs2761173; rs2793746; rs9585195; rs7986079; rs7982561; rs10508039; rs9557284; rs4771344; rs9513673; rs7989959; rs4772246; rs8002475; rs9517906; rs9513648; rs7982186; rs7327267; rs7326626; rs7333425; rs11069379; rs7334942; rs2390357; rs1022845; rs4772225; rs9585171; rs2038694; rs2806300; rs4772239; rs9517898; rs7981650; rs878418; rs912283; rs9557318; rs7334071; rs2761152; rs2298066; rs9517825; rs12427607; rs4511391; rs7338186; rs9513660; rs9585157; rs1107450; rs2153672; rs2806279; rs9557311; rs7336899; rs2806297; rs2390354; rs7331804; rs9554625; rs2761158; rs7991703; rs2761165; rs7327909; rs7996352; rs7999726; rs7995737; rs9300564; rs2761171; rs2761155; rs9554617; rs9517863; rs9300569; rs9585250; rs4340181; rs4772229; rs7323117; rs4525350; rs7317032; rs7984112; rs927596; rs7996792; rs9554636; rs2793748; rs9300565; rs9513675; rs6491521; rs17473570; rs9582350; rs16956874; rs6491531; rs4418926; rs7328417; rs7333886; rs9554624; rs12100265; rs17612226; rs9513658; rs9585169; rs2761154; rs7992587; rs2793758; rs17576658; rs7319374; rs2793787; rs12430038; rs10508040; rs9557309; rs7317678; rs17612198; rs7994564; rs8002591; rs9554618; rs7335639; rs11069374; rs4771343; rs12873858; rs4772240; rs9517814; rs17577167; rs9557290; rs9557321; rs7316944; rs9513664; rs12856441; rs9554639; rs2057488; rs7337354; rs2806278; rs2806307; rs1341399; rs12584570; rs8001493; rs4267173; rs6491525; rs9582351; rs2893010; rs9585252; rs9585161; rs2793769; rs9517885; rs7321513; rs6491532; rs9513653; rs7328387; rs9634449; rs2806298; rs7330733; rs4772222; rs721922; rs17612087; rs9554642; rs9517877; rs4334138; rs12584833; rs7326777; rs9557319; rs9300567; rs12431270; rs4771342; rs12877095; rs9557317; rs7330589; rs9517829; rs2806306; rs9517895; rs9557297; rs8000862; rs9557298; rs11620246; rs7328242; rs7995431; rs9513665; rs9517905; rs1924107; rs2806310; rs17612107; rs11616808; rs2806275; rs9585243; rs7335739; rs9554637; rs11840104; rs9557325; rs7994234; rs17657985; rs1555589; rs7323189; rs9513667; rs7991377; rs9585162; rs912659; rs9513672; rs9585211; rs9517869; rs7994919; rs11839315; rs2761167; rs1107382; rs4483710; rs9557308; rs7335678; rs10083230; rs12868139; rs2806302; rs9585226; rs11839716; rs2806309; rs9554634; rs4564437; rs9517871; rs9300570; rs7981201; rs2806286; rs12427494; rs9300561; rs12868090; rs9582329; rs11840327; rs7328023; rs4384480; rs4772236; rs912287; rs8000571; rs7326772; rs7998536; rs11839651; rs7323953; rs9517892; rs2761168; rs9517889; rs2057487; rs10083271; rs7332098; rs9517899; rs1125436; rs7319987; rs2282401; rs7139930; rs12430048; rs9513647; rs9585242; rs2250311; rs7330630; rs1886030; rs11842056; rs2793763; rs7319505; rs4772249; rs9557282; rs11839563; rs4771340; rs4290347; rs9554633; rs9585178; rs1028711; rs9517893; rs11069372; rs7139402; rs9513661; rs7999987; rs9513663; rs8000435; rs9517830; rs9557293; rs2806292; rs9585234; rs7994852; rs9554645; rs6491523; rs9585231; rs2793741; rs16956730; rs7987714; rs9670678; rs7995755; rs9517886; rs9517813; rs16956921; rs2181608; rs2793751; rs11839875; rs17576929; rs9585245; rs2182037; rs12875247; rs7324176; rs2390355; rs1987492; rs9582336; rs9517817; rs6491533; rs2761162; rs7986248; rs9300568; rs4772227; rs11839443; rs9517864; rs9634517; rs34667146; rs4772241; rs9517891; rs7318060; rs9513654; rs2806303; rs9517901; rs16956916; rs12429300; rs9513674; rs7332426; rs16956961; rs2390359; rs2761157; rs4377025; rs7995280; rs7993002; rs1028712; rs11616546; rs16956764; rs7988259; rs10851107; rs9585164; rs7985592; rs9585175; rs12877564; rs9517878; rs9557268; rs9585233; rs11069382; rs17658053; rs9585248; rs11839991; rs9585208; rs2763939; rs7326142; rs9513650; rs7319992; rs7333543; rs7985956; rs9670010; rs2763943; rs7987600; rs2793785; rs7984587; rs9517808; rs11069381; rs12869989; rs7338007; rs7998807; rs12866699; rs2763944; rs9517824; rs2000148; rs9557267; rs7983983; rs7993694; rs4411369; rs12018070; rs2181607; rs16957038; rs9582347; rs7986437; rs1111867; rs9300572; rs9517861; rs10454027; rs2027442; rs4439619; rs12585089; rs9513649; rs4505173; rs4772224; rs9300562; rs1544189; rs11616786; rs9517835; rs9585153; rs4772233; rs7317837; rs12184851; rs11843986; rs1555590; rs2793786; rs9557273; rs9554644; rs9517831; rs9557291; rs3831038; rs7989523; rs7988767; rs6491535; rs17611399; rs7329724; rs2793784; rs9557272; rs12427504; rs11840934; rs9557320; rs7982629; rs11842082; rs2761166; rs9517867; rs9517887; rs9585200; rs6491528; rs2793764; rs9582348; rs1125435; rs2761159; rs9554631; rs9585216; rs2390302; rs7335229; rs11619446; rs10851109; rs7987145; rs9517860; rs7318411; rs9513656; rs9557306; rs16957003; rs4772237; rs1924100; rs9517820; rs2806277; rs9585207; rs2806301; rs2806305; rs9585173; rs2761164; rs9585185; rs11842371; rs2763949; rs7986083; rs9582344; rs7490120; rs7981731; rs7321720; rs9517904; rs9557288; rs8002734; rs4771341; rs9554616; rs9517884; rs9517872; rs7317914; rs4288858; rs11840555; rs3033552; rs9517862; rs16956964; rs2806288; rs4772247; rs2236583; rs9557301; rs2763945; rs11841969; rs16956883; rs16957012; rs9517832; rs9513644; rs9557316; rs7320176; rs12429794; rs1924108; rs9557307; rs12584897; rs9517821; rs7995103; rs10454527; rs17473598; rs9517876; rs9517811; rs4360797; rs9517816; rs2761175; rs4771347; rs9585166; rs16956821; rs7986249; rs9582335; rs7319880; rs958764; rs9557304; rs9582345; rs12427647; rs10220173; rs9517897; rs17611302; rs2806293; rs8000012; rs9585186; rs9557271; rs2763938; rs9517837; rs9585244; rs9585172; rs11841056; rs7998088; rs1924110; rs9557323; rs9517827; rs9554646; rs2806304; rs9742582; rs2793754; rs9585206; rs17577153; rs2761161; rs912286; rs2390356; rs2806296; rs8000609; rs16956828; rs2793742; rs9513671; rs6491527; rs16956889; rs9557287; rs17657201; rs7995312; rs2806308; rs4424774; rs2761172; rs9557310; rs4400905; rs11843710; rs9557302; rs7328196; rs999631; rs2761170; rs4772235; rs7985416; rs7337811; rs2763946; rs7319139; rs11619680; rs11840467; rs7325119; rs9582331; rs1924109; rs9557269; rs12429830; rs13378481; rs9300557; rs9582338; rs7328521; rs869323; rs2763934; rs1886032; rs11616689; rs9582328; rs41281112; rs12873611; rs34411915; rs35611394; rs34078213; rs3742255; rs12873851; rs9585262; rs34625836; rs28642354; rs35177836; rs12869625; rs7995068; rs7986754; rs12017062; rs35024669; rs9585266; rs35061922; rs35546044; rs28698863; rs35358394; rs12018768; rs1924106; rs34875340; rs2209086; rs35968589; rs9585257; rs12874770; rs9585261; rs9517909; rs28660130; rs34773665; rs34896012; rs9585272; rs7992743; rs9517911; rs9557334; rs10707455; rs9557329; rs9585269; rs9585265; rs7327776; rs34366931; rs9585258; rs9582353; rs10635703; rs12017613; rs2209087; rs10598307; rs9585260; rs9517912; rs9557332; rs9585271; rs35025545; rs11435009; rs12872031; rs12561106; rs12873057; rs28592795; rs9585273; rs9557328; rs34151390; rs9585256; rs35912155; rs11362669; rs977610; rs2181610; rs9585267; rs2296116; rs9585270; rs9585259; rs7982619; rs9585205; rs35003302; rs10220015; rs35823298; rs34969571; rs11618807; rs9585147; rs12021159; rs7322953; rs11271366; rs7324313; rs7989192; rs9300563; rs9517874; rs9513677; rs9585160; rs7337684; rs35567603; rs36097438; rs34070975; rs11449148; rs9517804; rs13329008; rs9517823; rs9557322; rs12868239; rs11317797; rs12865200; rs34073523; rs9554643; rs28627688; rs9513639; rs35342610; rs12019528; rs35430864; rs34526549; rs9557283; rs12858482; rs36091331; rs7324907; rs35483940; rs7317490; rs8000287; rs10597168; rs9517881; rs11841929; rs9585154; rs9517846; rs9557270; rs34410535; rs35949973; rs34021200; rs10592053; rs34772610; rs34861520; rs9585152; rs34939381; rs35699728; rs7322521; rs9513642; rs1040996; rs35662060; rs35774183; rs9554635; rs34088240; rs7983817; rs9585224; rs34985378; rs2147624; rs7139645; rs9513651; rs9582346; rs3032477; rs34250062; rs10568410; rs3032445; rs12019531; rs12875806; rs34486737; rs34750084; rs12017299; rs11463686; rs7996829; rs9513669; rs11366826; rs9585230; rs4771345; rs2793765; rs9585227; rs4772234; rs2793766; rs41281114; rs10533615; rs9582332; rs12869202; rs35379429; rs12429721; rs34363176; rs5806134; rs34924763; rs28580696; rs9585220; rs11419450; rs9582339; rs1610001; rs9585217; rs7331354; rs7988332; rs7981233; rs12560998; rs2793737; rs9585149; rs35727678; rs12867987; rs4772226; rs10645961; rs34374186; rs12232034; rs10549994; rs36075018; rs2793755; rs9585194; rs35412408; rs5806131; rs11840479; rs9517855; rs35952137; rs35232603; rs12869622; rs35750065; rs10677584; rs9585201; rs35047223; rs35613958; rs7327405; rs12855403; rs9517850; rs35916895; rs12020709; rs9585183; rs9513679; rs34146197; rs34684474; rs34556034; rs11335800; rs36015545; rs11366362; rs9513662; rs35466928; rs35844376; rs35948793; rs9554627; rs11305509; rs12868722; rs4255648; rs12861278; rs2390358; rs36129096; rs34164127; rs9517851; rs35257355; rs34063235; rs9557314; rs35635065; rs7334733; rs9513646; rs34276188; rs10597169; rs35445984; rs10677824; rs9796290; rs35391365; rs2806291; rs28726082; rs927595; rs36015417; rs2793750; rs35508052; rs2806282; rs13378365; rs35423396; rs11278066; rs7994927; rs5806138; rs12016773; rs36044234; rs7984935; rs34500560; rs11309587; rs9585236; rs36145554; rs33916976; rs9557280; rs2793759; rs9517842; rs10642327; rs12875158; rs2806276; rs35128777; rs33929981; rs12866242; rs2793744; rs12021220; rs12867593; rs4771339; rs4772242; rs12856515; rs9557303; rs1963727; rs9513652; rs35624361; rs12862106; rs10645320; rs9585221; rs10648017; rs7325085; rs11343579; rs9557289; rs12873987; rs9582343; rs28373539; rs9585155; rs35229641; rs36013244; rs7992451; rs2806287; rs7986698; rs728604; rs35893746; rs9585204; rs28460044; rs10083293; rs34582077; rs2793747; rs12875920; rs9513641; rs10556030; rs5806135; rs9517812; rs34631016; rs9585219; rs9585212; rs9554638; rs9517873; rs34206687; rs9513659; rs36094711; rs9585144; rs9585177; rs7996041; rs34513643; rs7993488; rs34742862; rs35938901; rs12871842; rs9517852; rs2793743; rs34556416; rs12583116; rs12428299; rs28630466; rs5806132; rs9300559; rs34184534; rs35582976; rs35442779; rs35794092; rs12017446; rs28535907; rs35588884; rs36054864; rs11300050; rs35941109; rs11617836; rs9517807; rs7335906; rs12561426; rs35020187; rs9517870; rs9585156; rs35916119; rs28662865; rs9557326; rs12430026; rs35436226; rs9585253; rs34909317; rs35970090; rs7996371; rs16956897; rs11069380; rs12865204; rs9517880; rs35492194; rs2181606; rs34774913; rs35610893; rs9517843; rs9585228; rs7988250; rs34026761; rs4001025; rs34000442; rs9585176; rs9517865; rs9554628; rs33921953; rs9585191; rs10614481; rs9645897; rs9557264; rs7988572; rs12323058; rs5806139; rs11838666; rs35820957; rs9585184; rs35531654; rs9557300; rs7997298; rs33994560; rs7997104; rs11322280; rs7322080; rs9557275; rs35421489; rs35122845; rs36120094; rs2806294; rs10697990; rs5009289; rs9517836; rs9585150; rs12871547; rs9585241; rs35654270; rs9740926; rs34546130; rs9554622; rs9557274; rs1125310; rs10698265; rs28655761; rs7335847; rs34217364; rs7320067; rs34444426; rs9585222; rs12865205; rs9517822; rs12876701; rs34463702; rs11617075; rs34142988; rs28690058; rs35606459; rs7984121; rs4772232; rs11375965; rs10527051; rs34459686; rs4772243; rs2793757; rs10561602; rs35769084; rs2763937; rs9557279; rs34065607; rs35279065; rs28758716; rs9585255; rs35982336; rs11295981; rs35593548; rs9517833; rs9557285; rs2763941; rs12871537; rs34919433; rs34521848; rs35403713; rs34410635; rs4620824; rs9585145; rs4468465; rs34452564; rs9582334; rs4771338; rs7992348; rs35449822; rs34006709; rs5806136; rs9585238; rs35744796; rs7492046; rs7336931; rs13378364; rs9585196; rs10625169; rs10633371; rs35255826; rs9517858; rs28607319; rs10638638; rs9517848; rs12854991; rs34417938; rs35178164; rs9585235; rs28622077; rs34025247; rs7336414; rs12017577; rs35662106; rs34874271; rs34706273; rs12873782; rs9557294; rs9557265; rs35512772; rs35252192; rs11463227; rs9557299; rs35360400; rs12868198; rs10547821; rs35149509; rs35684540; rs10643696; rs11407509; rs2793740; rs10631675; rs34591731; rs11488858; rs35846449; rs9517828; rs11399409; rs9652119; rs11408587; rs4581571; rs4448786; rs9585180; rs9517894; rs2761160; rs9796140; rs2793739; rs10592189; rs9517839; rs9585232; rs9513676; rs36013148; rs11453486; rs12873787; rs9554630; rs11413739; rs2793768; rs17577328; rs9582330; rs11428657; rs11840697; rs10580515; rs12868144; rs34164966; rs9585254; rs12873329; rs34877692; rs4772228; rs13378360; rs9557292; rs9517853; rs34127469; rs5806140; rs34783138; rs34168768; rs36062611; rs9582349; rs7996029; rs9585215; rs34966114; rs2181611; rs9517868; rs34256215; rs34844714; rs35539387; rs9585229; rs2763936; rs4772231; rs34487469; rs12870132; rs4772244; rs10587468; rs9796139; rs7323206; rs12019527; rs9585214; rs35378080; rs5806137; rs35339021; rs1555592; rs9585158; rs9582341; rs34817821; rs12020266; rs34180901; rs34493491; rs11843458; rs35821572; rs9585192; rs2793788; rs11423267; rs35513599; rs35590185; rs9630323; rs35802185; rs9585174; rs34774349; rs34128794; rs9585237; rs7988847; rs5806133; rs12020817; rs34558107; rs9517849; rs9517826; rs9513657; rs10577448; rs9517806; rs9585197; rs2390303; rs1970474; rs34727243; rs9513668; rs5806130; rs10675151; rs9517834; rs2763942; rs9517883; rs9557278; rs10570896; rs7324908; rs9517840; rs2181609; rs7322341; rs12585649; rs9585181; rs12866164; rs9585163; rs9585179; rs35241030; rs10643154; rs35027014; rs35911559; rs28454189; rs9585146; rs9517890; rs12861546; rs34903136; rs12864654; rs12855629; rs11488857; rs4772248; rs7992906; rs9585218; rs4362246; rs34065473; rs34854735; rs12862668; rs2806289; rs35340874; rs2015510; rs35553024; rs35159870; rs9517809; rs9300560; rs36019690; rs10542003; rs28421311; rs7326701; rs3033587; rs9585182; rs34277836; rs35273988; rs34884800; rs9554640; rs12016925; rs9517859; rs9517882; rs9517845; rs9513643; rs9517903; rs28497020; rs34634591; rs10603999; rs11300591; rs34668722; rs11355981; rs35156803; rs10613474; rs9585209; rs35152575; rs5806141; rs7328182; rs4988681; rs4771346; rs9557281; rs9517841; rs7983978; rs9517854; rs9517875; rs34257176; rs35102124; rs35191910; rs12858356; rs28417881; rs9585202; rs4001024; rs9585193; rs9585151; rs34349227; rs36158602; rs34319588; rs34935488; rs12868025; rs35877939; rs12875051; rs35480092; rs12874188; rs36046210; rs1555591; rs11619740; rs7986124; rs4771337; rs17473738; rs11419451; rs2793767; rs2253561; rs2793753; rs9585247; rs35402626; rs35604496; rs7334160; rs2806299; rs7322262; rs9805698; rs9557324; rs34517548; rs11362747; rs34075621; rs7981210; rs9585148; rs2763935; rs869324; rs5806129; rs35113728; rs33913059; rs35215455; rs9513638; rs9517802; rs12876075; rs35123470; rs12874996; rs869325; rs35614015; rs1040998; rs10851106; rs11617237; rs12020463; rs12876007; rs17611025; rs1924102; rs1924103; rs2390337; rs2763932; rs2793783; rs35065101; rs4238223; rs4238224; rs4772250; rs4772253; rs6491518; rs7338383; rs7338818; rs7982361; rs8002910; rs9513637; rs9517914; rs9585276; rs9645895; rs9645896

# Macromolecular_Interacting_Partner_5_General_References:
Not Available

# Macromolecular_Interacting_Partner_5_References:
Not Available

# Macromolecular_Interacting_Partner_6_ID:
8821

# Macromolecular_Interacting_Partner_6_Name:
Solute carrier family 13 member 2

# Macromolecular_Interacting_Partner_6_Synonyms:
Renal sodium/dicarboxylate cotransporter; Na(+/dicarboxylate cotransporter 1; NaDC-1

# Macromolecular_Interacting_Partner_6_Gene_Name:
SLC13A2

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Solute carrier family 13 member 2
MATCWQALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTA
LFPLILFPMMGIVDASEVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVR
PAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSQASSNVEEGSNNPTFELQ
EPSPQKEVTKLDNGQALPVTSASSEGRAHLSQKHLHLTQCMSLCVCYSASIGGIATLTGT
APNLVLQGQINSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNFGI
GEKMQEQQQAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTREPGFFLGWGNLAFP
NAKGESMVSDGTVAIFIGIIMFIIPSKFPGLTQDPENPGKLKAPLGLLDWKTVNQKMPWN
IVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATT
TIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAG
FLLNIIGVLIIALAINSWGIPLFSLHSFPSWAQSNTTAQCLPSLANTTTPSP

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
592

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
64411

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
7.01

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
 Function:  transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  cation transport
Process:  monovalent inorganic cation transport
Process:  sodium ion transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Inorganic ion transport and metabolism

# Macromolecular_Interacting_Partner_6_Specific_Function:
Cotransport of sodium ions and dicarboxylates such as succinate and citrate

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00939:Na_sulph_symp

# Macromolecular_Interacting_Partner_6_Signals:
1-33

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
13-33
53-73
86-106
114-134
221-241
274-294
324-344
371-391
450-470
482-502
511-531
545-565

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
1098557

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
S13A2_HUMAN (Q13183)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SLC13A2

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SLC13A2

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:10917

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential)

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1779 bp
ATGGCCACCTGCTGGCAGGCCCTGTGGGCCTATCGCTCCTACCTGATCGTGTTCTTCGTG
CCCATTCTCCTGCTGCCTCTGCCCATCCTCGTCCCCAGTAAGGAGGCCTACTGCGCGTAT
GCCATCATCCTCATGGCGCTCTTCTGGTGCACTGAGGCCCTGCCCCTGGCCGTCACTGCC
CTCTTCCCCTTAATCCTGTTCCCTATGATGGGCATCGTGGATGCCTCTGAGGTTGCCGTC
GAGTATCTTAAGGACTCCAACCTCCTGTTCTTCGGGGGGCTGCTGGTGGCCATCGCGGTG
GAACACTGGAACCTGCATAAACGCATCGCCCTCCGTGTCCTCCTCATCGTTGGGGTGCGG
CCTGCCCCGCTAATCCTGGGCTTCATGCTGGTCACGGCCTTCCTGTCCATGTGGATCAGC
AACACGGCCACCTCAGCCATGATGGTGCCCATCGCACATGCCGTCCTGGACCAGCTGCAC
AGCTCGCAAGCCAGCAGCAACGTCGAGGAGGGCAGCAACAACCCCACCTTCGAGCTCCAG
GAACCAAGTCCCCAGAAGGAGGTGACCAAGCTTGATAATGGGCAGGCCCTCCCTGTCACG
TCTGCCTCTTCGGAGGGGAGGGCACATCTCAGCCAGAAGCATCTCCACCTCACCCAGTGC
ATGAGCCTGTGCGTGTGCTACTCCGCCAGCATCGGGGGCATCGCCACGCTGACTGGCACC
GCACCCAACCTGGTGCTGCAAGGCCAGATCAACTCGCTCTTCCCCCAAAACGGCAACGTG
GTGAACTTCGCCTCCTGGTTCAGCTTCGCCTTCCCCACCATGGTCATCTTGCTGCTGCTG
GCCTGGTTGTGGCTGCAGATCCTCTTCCTGGGCTTCAACTTCCGGAAGAACTTTGGCATT
GGGGAAAAGATGCAGGAGCAACAGCAGGCAGCCTACTGCGTCATCCAGACCGAGCACAGG
CTGCTGGGCCCCATGACCTTTGCAGAAAAGGCCATCAGCATCCTATTCGTCATCCTGGTG
CTGCTCTGGTTCACCCGGGAGCCGGGCTTTTTTCTTGGCTGGGGCAATTTGGCTTTTCCC
AATGCCAAGGGGGAGAGCATGGTGTCCGATGGGACAGTGGCCATCTTCATCGGCATAATT
ATGTTCATCATACCCTCCAAGTTCCCAGGGCTGACCCAGGACCCAGAAAACCCAGGGAAG
CTGAAGGCCCCTCTTGGCCTCCTCGACTGGAAGACGGTGAACCAGAAGATGCCGTGGAAT
ATCGTGTTATTGCTGGGTGGTGGCTATGCCCTGGCCAAGGGCAGTGAGCGATCGGGCCTG
TCAGAGTGGCTGGGAAACAAGCTGACCCCACTGCAGAGTGTGCCAGCTCCAGCCATTGCC
ATCATCCTCTCCCTCCTGGTGGCCACCTTCACCGAGTGCACTAGCAACGTGGCCACCACT
ACGATCTTCCTGCCCATCCTAGCCTCCATGGCCCAGGCCATCTGCCTCCACCCTCTCTAC
GTCATGCTCCCCTGCACTCTGGCCACCTCCCTGGCCTTCATGTTGCCTGTGGCCACCCCG
CCCAATGCCATCGTCTTCTCTTTCGGGGACCTCAAAGTGTTGGATATGGCCCGGGCAGGA
TTCCTCCTCAACATCATTGGAGTCCTGATCATCGCACTGGCCATCAACAGCTGGGGCATC
CCCCTCTTCAGCCTGCACTCTTTCCCCTCCTGGGCACAGTCCAACACCACAGCCCAGTGC
CTGCCAAGCCTGGCCAACACCACCACACCAAGCCCCTAG

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
U26209

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_6_Locus:
17p13.2

# Macromolecular_Interacting_Partner_6_SNPs:
rs11567842; rs16964363; rs11278972; rs1974589; rs1990288; rs9890678; rs8070486; rs2072335; rs1990287; rs9909420; rs9896507; rs2108976; rs2017745; rs1558220; rs11443311; rs9896993; rs12939182; rs11652129; rs12449414; rs2072334; rs11654250; rs9898856; rs12941530; rs8069066; rs11657539; rs3764866; rs5819848; rs34926480; rs35840529; rs9914826; rs9898544; rs35182772; rs34967789; rs34687732; rs35548456; rs34480640; rs28459755; rs11656118; rs9906373; rs35830728; rs9914322; rs3217046; rs12602773; rs35702494; rs35141140; rs34923898; rs34122675; rs35873969; rs2159294; rs35990216; rs7224510; rs8069472; rs7207436; rs35355133; rs4795444; rs12937391; rs34493124; rs9890282; rs28731233; rs28585543; rs9906255; rs11080064; rs11568439; rs11568440; rs11568442; rs11568443; rs11568452; rs11568459; rs11568460; rs11568462; rs11568463; rs11568465; rs11568466; rs11568467; rs11568473; rs11568475; rs11568478; rs11654702; rs11658407; rs12451081; rs16964368; rs16964373; rs17719981; rs2191090; rs4340375; rs4483904; rs4511587; rs4566227; rs4569345; rs4581750; rs4636956; rs6505084; rs6505085; rs7406210; rs7501880; rs758436; rs8067630; rs8073655; rs8074596; rs8078229; rs9897019; rs9905249; rs9913637

# Macromolecular_Interacting_Partner_6_General_References:
8967342

# Macromolecular_Interacting_Partner_6_References:
Not Available

End of HMDB00094

Beginning of HMDB00095
# Accession_No:
HMDB00095

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-05-23 11:58:53

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Cytidine monophosphate

# Description:
Cytidine monophosphate, also known as 5'-cytidylic acid and abbreviated CMP, is a nucleotide that is found in RNA. It is an ester of phosphoric acid with the nucleoside cytidine. CMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase cytosine.

# Synonyms:
5'-CMP; 5Cytidylate; 5Cytidylic acid; CMP; Cytidine 5'-monophosphate; Cytidine 5'-monophosphorate; Cytidine 5'-monophosphoric acid; Cytidine 5'-phosphate; Cytidine 5'-phosphorate; Cytidine 5'-phosphoric acid; Cytidine mono(dihydrogen phosphate); Cytidine monophosphate; Cytidylate; Cytidylic acid

# Chemical_IUPAC_Name:
[5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid

# Chemical_Formula:
C9H14N3O8P

# Chemical_Structure:
tbl_chemical:::HMDB00095_ZOOM.png:::119283186680745367

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00095_THUMB.png:::119283186461083892

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines; Nucleoside Phosphates

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; secondary alcohol; 1,2-diol; primary amine; primary aromatic amine; oxo(het)arene; urea; phosphoric acid ester; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of Ganglioside biosynthesis; Component of Globoside metabolism; Component of Glycerophospholipid metabolism; Component of Keratan sulfate biosynthesis; Component of N-Glycan biosynthesis; Component of O-Glycan biosynthesis; Component of Pyrimidine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
323.05185

# Molecular_Weight_Avg:
323.19650

# Smiles_String_isomeric:
NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O

# Smiles_String_canonical:
NC1=NC(=O)N(C=C1)C2OC(COP(O)(O)=O)C(O)C2O

# KEGG_Compound_ID:
C00055

# BioCyc_ID:
CMP

# PubChem_CID:
6131

# PubChem_SID:
825871; 841433; 7886446; 854931; 149026; 830793; 823878; 584300; 835515; 584639; 583618; 10318305; 831879; 821548; 835139; 7886416; 824496; 833329; 824237; 3725901; 8144170; 8153842; 3139556; 831883; 584637; 836377; 821538; 820933; 585256; 831880; 3357; 177161; 10317158

# OMIM_ID:
258900; 269921

# Metagene_ID:
Not Available

# BiGG_ID:
33689

# Wikipedia_ID:
Cytidine monophosphate

# METLIN_ID:
5143

# Ref_ID:
6307548; 16225392; 6267956; 234961; 6313098; 6748871; 9171454; 3028466

# ChEBI_ID:
17361

# CAS_Registry_Number:
63-37-6

# InChI:
InChI=1/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

# Synthesis_Reference:
Synthesis of cytidine diphosphate glycerol.     Baddiley, J.; Buchanan, J. G.; Sanderson, A. R.    Univ. Durham,  UK.    Journal of the Chemical Society  (1958),     3107-10.

# Melting_Point:
233 oC

# Melting_Point_predicted:
133.8 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
98.6 mg/mL [MEYLAN,WM et al. (1996)]; 16.3 mg/mL [Predicted by ALOGPS]

# phys_charge:
-2

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.05 [Predicted by ALOGPS]; -4.2 [Predicted by PubChem via XLOGP]; -2.75 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Cytidine 5'-monophosphate.pdf:::113256219930778642

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Cytidine_monophosphate.mol:::1132723806843517232

# SDF_File_[Text]:
tbl_chemical:::HMDB00095.sdf:::119283185960512000

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00095.pdb:::119283186308146014

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041025_P00_01_HW_1DP_presat.png:::114807236438731242

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041025_P00_01_HW_1DP_presat.zip:::114807257644423681

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041025_P00_01_HW_1DP_Assigned.png:::115643772460377070

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041025_P00_01_HW_2DHSQC_669.png:::114789937694127035

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041025_P00_01_HW_2DHSQC_669.zip:::114789937696424741

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041025_P00_01_HW_2DHSQC_669_Assigned.png:::115332766369228001

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Cytidine monophosphate.gif:::1132732108125343197

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00095_peaks.txt:::1156309541041974446

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Cytidine monophosphate_C.gif:::1132737681882758104

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00095_peaks.txt:::1156310731292794526

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP); Extracellular; golgi apparatus; lysosome; mitochondria; nucleus

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood

# Concentration_[Normal]:
Not Available


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Leukemia; Pyrimidine 5'-nucleotidase (P5N) deficiency

# Pathway_Names:
Purine metabolism;Keratan sulfate biosynthesis;Glycerophospholipid metabolism;Phosphatidylinositol signaling system;Nicotinate and nicotinamide metabolism;N-Glycan biosynthesis;Blood group glycolipid biosynthesis-lactoseries

# Pathway_Images:
Purine_Synthesis.jpg;;;;Nicotinamide_synthesis_(NADH).jpg;;

# KEGG_Images:
map00230;map00533;map00564;map04070;map00760;map00510;

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;;;;Nicotinamide_synthesis_(NADH)_Graph.jpg;;

# Pathway_SBMLs:
Purine_Synthesis.xml;;;;Nicotinamide_synthesis_(NADH).xml;;

# Metabolic_Enzyme_1_ID:
5318

# Metabolic_Enzyme_1_Name:
Ectonucleoside triphosphate diphosphohydrolase 3

# Metabolic_Enzyme_1_Synonyms:
NTPDase 3; Ecto-ATP diphosphohydrolase; ATPDase; Ecto-apyrase; CD39 antigen-like 3; HB6

# Metabolic_Enzyme_1_Gene_Name:
ENTPD3

# Metabolic_Enzyme_1_Protein_Sequence:
>Ectonucleoside triphosphate diphosphohydrolase 3
MFTVLTRQPCEQAGLKALYRTPTIIALVVLLVSIVVLVSITVIQIHKQEVLPPGLKYGIV
LDAGSSRTTVYVYQWPAEKENNTGVVSQTFKCSVKGSGISSYGNNPQDVPRAFEECMQKV
KGQVPSHLHGSTPIHLGATAGMRLLRLQNETAANEVLESIQSYFKSQPFDFRGAQIISGQ
EEGVYGWITANYLMGNFLEKNLWHMWVHPHGVETTGALDLGGASTQISFVAGEKMDLNTS
DIMQVSLYGYVYTLYTHSFQCYGRNEAEKKFLAMLLQNSPTKNHLTNPCYPRDYSISFTM
GHVFDSLCTVDQRPESYNPNDVITFEGTGDPSLCKEKVASIFDFKACHDQETCSFDGVYQ
PKIKGPFVAFAGFYYTASALNLSGSFSLDTFNSSTWNFCSQNWSQLPLLLPKFDEVYARS
YCFSANYIYHLFVNGYKFTEETWPQIHFEKEVGNSSIAWSLGYMLSLTNQIPAESPLIRL
PIEPPVFVGTLAFFTAAALLCLAFLAYLCSATRRKRHSEHAFDHAVDSD

# Metabolic_Enzyme_1_Number_of_Residues:
529

# Metabolic_Enzyme_1_Molecular_Weight:
59106

# Metabolic_Enzyme_1_Theoretical_pI:
6.40

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Has a threefold preference for the hydrolysis of ATP over ADP

# Metabolic_Enzyme_1_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_1_Reaction:
ATP + 2 H2O = AMP + 2 phosphate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01150:GDA1_CD39

# Metabolic_Enzyme_1_Signals:
1-37

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.6.1.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
3335100

# Metabolic_Enzyme_1_SwissProt_ID:
ENTP3_HUMAN (O75355)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ENTPD3

# Metabolic_Enzyme_1_Geneatlas_id:
ENTPD3

# Metabolic_Enzyme_1_hgnc_id:
HGNC:3365

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential)

# Metabolic_Enzyme_1_Gene_Sequence:
>1590 bp
ATGTTCACTGTGCTGACCCGCCAACCATGTGAGCAAGCAGGCCTCAAGGCCCTCTACCGA
ACTCCAACCATCATTGCCTTGGTGGTCTTGCTTGTGAGTATTGTGGTACTTGTGAGTATC
ACTGTCATCCAGATCCACAAGCAAGAGGTCCTCCCTCCAGGACTGAAGTATGGTATTGTG
CTGGATGCCGGGTCTTCAAGAACCACAGTCTACGTGTATCAATGGCCAGCAGAAAAAGAG
AATAATACCGGAGTGGTCAGTCAAACCTTCAAATGTAGTGTGAAAGGCTCTGGAATCTCC
AGCTATGGAAATAACCCCCAAGATGTCCCCAGAGCCTTTGAGGAGTGTATGCAAAAAGTC
AAGGGGCAGGTTCCATCCCACCTCCACGGATCCACCCCCATTCACCTGGGAGCCACGGCT
GGGATGCGCTTGCTGAGGTTGCAAAATGAAACAGCAGCTAATGAAGTCCTTGAAAGCATC
CAAAGCTACTTCAAGTCCCAGCCCTTTGACTTTAGGGGTGCTCAAATCATTTCTGGGCAA
GAAGAAGGGGTATATGGATGGATTACAGCCAACTATTTAATGGGAAATTTCCTGGAGAAG
AACCTGTGGCACATGTGGGTGCACCCGCATGGAGTGGAAACCACGGGTGCCCTGGACTTA
GGTGGTGCCTCCACCCAAATATCCTTCGTGGCAGGAGAGAAGATGGATCTGAACACCAGC
GACATCATGCAGGTGTCCCTGTATGGCTACGTATACACGCTCTACACACACAGCTTCCAG
TGCTATGGCCGGAATGAGGCTGAGAAGAAGTTTCTGGCAATGCTCCTGCAGAATTCTCCT
ACCAAAAACCATCTCACCAATCCCTGTTACCCTCGGGATTATAGCATCAGCTTCACCATG
GGCCATGTATTTGATAGCCTGTGCACTGTGGACCAGAGGCCAGAAAGTTATAACCCCAAT
GATGTCATCACTTTTGAAGGAACTGGGGACCCATCTCTGTGTAAGGAGAAGGTGGCTTCC
ATATTTGACTTCAAAGCTTGCCATGATCAAGAAACCTGTTCTTTTGATGGGGTTTATCAG
CCAAAGATTAAAGGGCCATTTGTGGCTTTTGCAGGATTCTACTACACAGCCAGTGCTTTA
AATCTTTCAGGTAGCTTTTCCCTGGACACCTTCAACTCCAGCACCTGGAATTTCTGCTCA
CAGAATTGGAGTCAGCTCCCACTGCTGCTCCCCAAATTTGATGAGGTATATGCCCGCTCT
TACTGCTTCTCAGCCAACTACATCTACCACTTGTTTGTGAACGGTTACAAATTCACAGAG
GAGACTTGGCCCCAAATACACTTTGAAAAAGAAGTGGGGAATAGCAGCATAGCCTGGTCT
CTTGGCTACATGCTCAGCCTGACCAACCAGATCCCAGCTGAAAGCCCTCTGATCCGTCTG
CCCATAGAACCACCTGTCTTTGTGGGCACCCTCGCTTTCTTCACAGTGGCAGCCTTGCTG
TGTCTGGCATTTCTTGCATACCTGTGTTCAGCAACCAGAAGAAAGAGGCACTCCGAGCAT
GCCTTTGACCATGCAGTGGATTCTGACTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF039917

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_1_Locus:
3p21.3

# Metabolic_Enzyme_1_SNPs:
rs1047855; rs2305521; rs9858868; rs11714871; rs17078798; rs2305522; rs12493020; rs897117; rs1466236; rs6599101; rs6808095; rs9332450; rs6599102; rs954589; rs6783755; rs9848083; rs951560; rs7645864; rs7636719; rs4973999; rs9829800; rs4973997; rs4973898; rs7648952; rs12490249; rs13324109; rs17079011; rs9849348; rs9873394; rs17078941; rs17078813; rs1466237; rs7634375; rs1105745; rs7631893; rs9822909; rs9859026; rs1466238; rs7625736; rs4283549; rs17078812; rs9857824; rs6793596; rs11707673; rs11714032; rs11720360; rs6599100; rs9875245; rs2371185; rs6804157; rs17078914; rs11921197; rs17078916; rs12492035; rs4973994; rs17078921; rs4973989; rs17078959; rs13099333; rs1037516; rs12490275; rs3774805; rs4973998; rs12492777; rs6796122; rs4973993; rs13326389; rs13321169; rs12491944; rs12634013; rs13081891; rs11920596; rs9848049; rs13066971; rs12636697; rs6807397; rs9864380; rs34266806; rs4470483; rs17852714; rs3733167; rs41286046; rs35071108; rs6773917; rs10671439; rs35839072; rs35836679; rs9874499; rs10551054; rs13073943; rs10565031; rs13094752; rs10620040; rs11351492; rs34255517; rs34665572; rs3774806; rs10575365; rs5848563; rs951561; rs13082239; rs3064608; rs11445995; rs9809377; rs35636349; rs35489659; rs4560275; rs6798459; rs10620057; rs13316488; rs13082375; rs6797651; rs6795906; rs13073946; rs3064609; rs41286044; rs35641310; rs35870509; rs13082222; rs13090979; rs9836330; rs34726619; rs28465354; rs10650731; rs9883218; rs9863737; rs9829324; rs1105746; rs5848564; rs9833430; rs9880286; rs9864423; rs3774807; rs28621801; rs34065066; rs6767610; rs11415995; rs3064615; rs35700770; rs5848565; rs9882941; rs34145192; rs34654655; rs10658778; rs11360523; rs9843979; rs36074810; rs9843965; rs13072002; rs35267876; rs41286048; rs9860002; rs9863679; rs13433935; rs35860386; rs9882954; rs11371152; rs9809378; rs28671141; rs28508335; rs34934417; rs6808552; rs10594515; rs9828299; rs1119179; rs12488805; rs12492578; rs12494022; rs2371184; rs6762997; rs6795066; rs7610586; rs7616273; rs7642552; rs9813231; rs9817233; rs9822644; rs9835219; rs9841335; rs9846606; rs9871825; rs9874006; rs9882464

# Metabolic_Enzyme_1_General_References:
9676430; 9675246; 10231536; 11300774

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6048

# Metabolic_Enzyme_2_Name:
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase

# Metabolic_Enzyme_2_Synonyms:
Beta-galactoside alpha-2,3-sialyltransferase; Alpha 2,3-ST; Gal-NAc6S; Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; ST3GalA.2; SIAT4-B; ST3Gal II

# Metabolic_Enzyme_2_Gene_Name:
ST3GAL2

# Metabolic_Enzyme_2_Protein_Sequence:
>CMPNacetylneuraminatebetagalactosamidealpha2,3sialyltransferase
MKCSLRVWFLSVAFLLVFIMSLLFTYSHHSMATLPYLDSGALDGTHRVKLVPGYAGLQRL
SKERLSGKSCACRRCMGDAGASDWFDSHFDGNISPVWTRENMDLPPDVQRWWMMLQPQFK
SHNTNEVLEKLFQIVPGENPYRFRDPHQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMN
QAPTVGFEQDVGSRTTHHFMYPESAKNLPANVSFVLVPFKVLDLLWIASALSTGQIRFTY
APVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFG
ADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYRGN

# Metabolic_Enzyme_2_Number_of_Residues:
350

# Metabolic_Enzyme_2_Molecular_Weight:
40173

# Metabolic_Enzyme_2_Theoretical_pI:
8.47

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  sialyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  intrinsic to organelle membrane
Component:  intrinsic to Golgi membrane
Component:  integral to Golgi membrane

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values

# Metabolic_Enzyme_2_Pathway:
Not Available

# Metabolic_Enzyme_2_Reaction:
Not Available

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00777:Glyco_transf_29

# Metabolic_Enzyme_2_Signals:
1-27

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.4.99.4

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1773283

# Metabolic_Enzyme_2_SwissProt_ID:
SIA4B_HUMAN (Q16842)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ST3GAL2

# Metabolic_Enzyme_2_Geneatlas_id:
ST3GAL2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:10863

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Golgi apparatus; Golgi stack; Golgi stack membrane; single-pass type II membrane protein. Secreted protein (By similarity). Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid (By similarity)

# Metabolic_Enzyme_2_Gene_Sequence:
>1053 bp
ATGAAGTGCTCCCTGCGGGTGTGGTTCCTCTCCGTGGCCTTCCTGCTGGTGTTCATCATG
TCCCTGCTCTTCACCTACTCGCACCACAGCATGGCCACGCTCCCCTACCTGGACTCAGGG
GCCCTGGATGGGACGCACCGGGTGAAGCTGGTGCCCGGCTATGCCGGCCTGCAGCGCCTC
AGCAAGGAGAGGCTCTCGGGCAAGAGCTGTGCCTGTCGCCGCTGCATGGGCGATGCCGGT
GCCTCCGACTGGTTTGACAGCCACTTTGACGGTAACATTTCCCCCGTCTGGACCCGAGAG
AACATGGATCTTCCACCGGACGTCCAGAGGTGGTGGATGATGCTGCAGCCCCAGTTCAAG
TCACACAACACCAATGAGGTGCTGGAGAAGCTGTTCCAGATAGTGCCTGGCGAGAACCCC
TACCGCTTCCGGGACCCCCACCAGTGCCGGCGCTGTGCCGTGGTGGGGAACTCGGGCAAC
CTGCGGGGCTCTGGCTATGGGCAGGACGTGGACGGGCACAACTTCATCATGAGGATGAAT
CAGGCGCCAACCGTGGGCTTTGAGCAGGATGTTGGCAGCCGAACCACCCACCATTTCATG
TACCCTGAGAGTGCCAAGAACCTGCCCGCCAACGTCAGCTTCGTGCTGGTGCCCTTCAAG
GTCCTGGACCTTCTGTGGATCGCCAGCGCCTTGTCCACGGGGCAGATCCGATTCACCTAC
GCCCCAGTGAAGTCCTTCCTTCGAGTGGATAAAGAAAAGGTCCAGATCTACAACCCAGCC
TTCTTCAAGTATATCCACGACAGGTGGACAGAGCATCACGGGCGGTACCCTTCCACGGGG
ATGCTGGTGCTTTTCTTTGCCCTGCATGTGTGTGATGAGGTGAACGTGTACGGGTTCGGG
GCCGACAGCCGGGGCAACTGGCACCACTACTGGGAGAACAACCGGTACGCGGGCGAGTTC
CGGAAGACTGGCGTGCACGACGCGGACTTCGAGGCCCACATCATCGACATGCTGGCCAAG
GCCAGCAAGATCGAAGTCTACCGGGGCAACTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
U63090

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_2_Locus:
16q22.1

# Metabolic_Enzyme_2_SNPs:
rs936994; rs891138; rs11863943; rs3852695; rs11867150; rs9921696; rs9934440; rs7195104; rs16970159; rs16970165; rs11864326; rs11647932; rs11861246; rs8052907; rs16970149; rs16970154; rs16970169; rs3852696; rs7195086; rs2634411; rs16970153; rs11865484; rs16970152; rs16970151; rs6499312; rs7199655; rs8046296; rs16970141; rs16970147; rs7188864; rs11075763; rs4985526; rs8062183; rs2229570; rs35467022; rs34874526; rs34652076; rs28491205; rs28396934; rs4548852; rs5817696; rs8059693; rs35113756; rs34222045; rs12925393; rs12932115; rs12927661; rs11865394; rs9939726; rs2903523; rs12935225; rs35964576; rs1048142; rs10547646; rs28848878; rs35994886; rs36115940; rs775196; rs13337689; rs34837520; rs7200891; rs12930842; rs35682945; rs34296192; rs4999488; rs2634410; rs12927258; rs12922813; rs2575378; rs5817695; rs4995098; rs34924977; rs34109485; rs9924352; rs9940841; rs8058735; rs4999489; rs35917313; rs5817698; rs10605519; rs11639541; rs35502901; rs28600269; rs4995099; rs11385970; rs4985409; rs28838669; rs1979594; rs11304215; rs35688268; rs12928082; rs11421656; rs36100329; rs8046253; rs34862900; rs34907504; rs34764880; rs35885469; rs35024720; rs36233225; rs11353666; rs11354613; rs11354612; rs10542332; rs12149396; rs12928037; rs13334595; rs9921538; rs15596; rs11642006; rs12918154; rs16970133; rs17651821; rs2304491; rs34675027; rs6499314; rs8058557; rs8059844; rs9934707

# Metabolic_Enzyme_2_General_References:
8920913; 9266697

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6049

# Metabolic_Enzyme_3_Name:
Phosphatidylcholine:ceramide cholinephosphotransferase 2

# Metabolic_Enzyme_3_Synonyms:
Sphingomyelin synthase 2

# Metabolic_Enzyme_3_Gene_Name:
Not Available

# Metabolic_Enzyme_3_Protein_Sequence:
>Phosphatidylcholine:ceramide cholinephosphotransferase 2
MDIIETAKLEEHLENQPSDPTNTYARPAEPVEEENKNGNGKPKSLSSGLRKGTKKYPDYI
QIAMPTESRNKFPLEWWKTGIAFIYAVFNLVLTTVMITVVHERVPPKELSPPLPDKFFDY
IDRVKWAFSVSEINGIILVGLWITQWLFLRYKSIVGRRFCFIIGTLYLYRCITMYVTTLP
VPGMHFQCAPKLNGDSQAKVQRILRLISGGGLSITGSHILCGDFLFSGHTVTLTLTYLFI
KEYSPRHFWWYHLICWLLSAAGIICILVAHEHYTIDVIIAYYITTRLFWWYHSMANEKNL
KVSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWPPGCFKSSCKKYSRVQKIGED
NEKST

# Metabolic_Enzyme_3_Number_of_Residues:
365

# Metabolic_Enzyme_3_Molecular_Weight:
42281

# Metabolic_Enzyme_3_Theoretical_pI:
9.00

# Metabolic_Enzyme_3_GO_Classification:
Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Bidirectional lipid cholinephosphotransferases capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase

# Metabolic_Enzyme_3_Pathway:
Not Available

# Metabolic_Enzyme_3_Reaction:
Not Available

# Metabolic_Enzyme_3_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
80-100
128-148
159-179
206-226
248-268
275-295

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.7.8.27

# Metabolic_Enzyme_3_GenBank_ID_Protein:
30023566

# Metabolic_Enzyme_3_SwissProt_ID:
SMS2_HUMAN (Q8NHU3)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
Not Available

# Metabolic_Enzyme_3_Geneatlas_id:
Not Available

# Metabolic_Enzyme_3_hgnc_id:
Not Available

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cell membrane; multi-pass membrane protein. Golgi apparatus; Golgi apparatus membrane; multi-pass membrane protein. Note=Predominantly plasma membrane, some in Golgi apparatus

# Metabolic_Enzyme_3_Gene_Sequence:
>1098 bp
ATGGATATCATAGAGACAGCAAAACTTGAAGAACATTTGGAAAATCAACCCAGTGATCCT
ACGAACACTTATGCAAGACCCGCTGAACCTGTTGAAGAAGAAAACAAAAATGGCAATGGT
AAACCCAAGAGCTTATCCAGTGGGCTGCGAAAAGGCACCAAAAAGTACCCGGACTATATC
CAAATTGCTATGCCCACTGAATCAAGGAACAAATTTCCACTAGAGTGGTGGAAAACGGGC
ATTGCCTTCATATATGCAGTTTTCAACCTCGTCTTGACAACCGTCATGATCACAGTTGTA
CATGAGAGGGTCCCTCCCAAGGAGCTTAGCCCTCCACTCCCAGACAAGTTTTTTGATTAC
ATTGATAGGGTGAAATGGGCATTTTCTGTATCAGAAATAAATGGGATTATATTAGTTGGA
TTATGGATCACCCAGTGGCTGTTTCTGAGATACAAGTCAATAGTGGGACGCAGATTCTGT
TTTATTATTGGAACTTTATACCTGTATCGCTGCATTACAATGTATGTTACTACTCTACCT
GTGCCTGGAATGCATTTCCAGTGTGCTCCAAAGCTCAATGGAGACTCTCAGGCAAAAGTT
CAACGGATTCTACGATTGATTTCTGGTGGTGGATTGTCCATAACTGGATCACATATCTTA
TGTGGAGACTTCCTCTTCAGCGGTCACACGGTTACGCTGACACTGACTTATTTGTTCATC
AAAGAATATTCGCCTCGTCACTTCTGGTGGTATCATTTAATCTGCTGGCTGCTGAGTGCT
GCCGGGATCATCTGCATTCTTGTAGCACACGAACACTACACTATCGATGTGATCATTGCT
TATTATATCACAACACGACTGTTTTGGTGGTACCATTCAATGGCCAATGAAAAGAACTTG
AAGGTCTCTTCACAGACTAATTTCTTATCTCGAGCATGGTGGTTCCCCATCTTTTATTTT
TTTGAGAAAAATGTACAAGGCTCAATTCCTTGCTGCTTCTCCTGGCCGCTGTCTTGGCCT
CCTGGCTGCTTCAAATCATCATGCAAAAAGTATTCACGGGTTCAGAAGATTGGTGAAGAC
AATGAGAAATCGACCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
AF452717

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
Not Available

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5231

# Metabolic_Enzyme_4_Name:
UMP-CMP kinase

# Metabolic_Enzyme_4_Synonyms:
Cytidylate kinase; Deoxycytidylate kinase; Cytidine monophosphate kinase; Uridine monophosphate/cytidine monophosphate kinase; UMP/CMP kinase; UMP/CMPK; Uridine monophosphate kinase

# Metabolic_Enzyme_4_Gene_Name:
CMPK

# Metabolic_Enzyme_4_Protein_Sequence:
>
UMPCMP kinaseMKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDS
QYGELIEKYIKEGKIVPVEITISLLKREMDQTMAANAQKNKFLIDGFPRNQDNLQGWNKT
MDGKADVSFVLFFDCNNEICIERCLERGKSSGRSDDNRESLEKRIQTYLQSTKPIIDLYE
EMGKVKKIDASKSVDEVFDEVVQIFDKEG

# Metabolic_Enzyme_4_Number_of_Residues:
196

# Metabolic_Enzyme_4_Molecular_Weight:
22223

# Metabolic_Enzyme_4_Theoretical_pI:
5.20

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleotide kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes specific phosphoryl transfer from ATP to UMP and CMP

# Metabolic_Enzyme_4_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_4_Reaction:
ATP + (d)CMP = ADP + (d)CDP

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00406:ADK

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.7.4.14

# Metabolic_Enzyme_4_GenBank_ID_Protein:
6578133

# Metabolic_Enzyme_4_SwissProt_ID:
KCY_HUMAN (P30085)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CMPK

# Metabolic_Enzyme_4_Geneatlas_id:
CMPK

# Metabolic_Enzyme_4_hgnc_id:
HGNC:18170

# Metabolic_Enzyme_4_PDB_ID:
1TEV

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Nucleus. Cytoplasm. Note=Mainly nuclear

# Metabolic_Enzyme_4_Gene_Sequence:
>687 bp
ATGCTGAGCCGCTGCCGCAGCGGGCTGCTCCACGTCCTGGGCCTTAGCTTCCTGCTGCAG
ACCCGCCGGCCGATTCTCCTCTGCTCTCCACGTCTCATGAAGCCGCTGGTCGTGTTCGTC
CTCGGCGGCCCCGGCGCCGGCAAGGGGACCCAGTGCGCCCGCATCGTCGAGAAATATGGC
TACACACACCTTTCTGCAGGAGAGCTGCTTCGTGATGAAAGGAAGAACCCAGATTCACAG
TATGGTGAACTTATTGAAAAGTACATTAAAGAAGGAAAGATTGTACCAGTTGAGATAACC
ATCAGTTTATTAAAGAGGGAAATGGATCAGACAATGGCTGCCAATGCTCAGAAGAATAAA
TTCTTGATTGATGGGTTTCCAAGAAATCAAGACAACCTTCAAGGATGGAACAAGACCATG
GATGGGAAGGCAGATGTATCTTTCGTTCTCTTTTTTGACTGTAATAATGAGATTTGTATT
GAACGATGTCTTGAGAGGGGAAAGAGTAGTGGTAGGAGTGATGACAACAGAGAGAGCTTG
GAAAAGAGAATTCAGACCTACCTTCAGTCAACAAAGCCAATTATTGACTTATATGAAGAA
ATGGGGAAAGTCAAGAAAATAGATGCTTCTAAATCTGTTGATGAAGTTTTTGATGAAGTT
GTGCAGATTTTTGACAAGGAAGGCTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF070416

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_4_Locus:
1p32

# Metabolic_Enzyme_4_SNPs:
rs35687416; rs6656779; rs1044457; rs3088062; rs6795; rs3125648; rs2820981; rs17103161; rs2622925; rs10789507; rs12718447; rs10890478; rs2622903; rs2820989; rs6660321; rs4492666; rs4926836; rs10890477; rs11211523; rs3122620; rs4926840; rs4926824; rs11802287; rs12123269; rs12132521; rs7534328; rs12117686; rs12749507; rs6659946; rs11211521; rs9436882; rs11211524; rs2245850; rs11584518; rs2820986; rs11211520; rs2820994; rs11582877; rs2306470; rs12090346; rs9436883; rs2250183; rs12068451; rs3122621; rs4926839; rs2622902; rs2622908; rs12081190; rs2253511; rs4926838; rs12087353; rs4926544; rs11211518; rs11211522; rs2622918; rs2820984; rs12562561; rs12083822; rs2622911; rs3125639; rs2622914; rs12566521; rs2622901; rs11579854; rs3125646; rs6698471; rs7541522; rs6588365; rs6698717; rs2246707; rs3122623; rs7532785; rs2622913; rs3122622; rs12567687; rs3925058; rs9988633; rs11211517; rs7543016; rs11554567; rs3835608; rs10198; rs2820990; rs10639560; rs28797184; rs11368245; rs10623948; rs6684213; rs6681868; rs13375896; rs34192192; rs2246708; rs35072721; rs2622912; rs35234940; rs6696620; rs4600090; rs28461889; rs34536867; rs12031563; rs10713246; rs35624696; rs5773945; rs11379501; rs12127982; rs3122610; rs2622924; rs35175280; rs2820993; rs28752184; rs34677520; rs11578038; rs35560035; rs11444039; rs7529388; rs12030848; rs3125643; rs34979288; rs35068095; rs3125640; rs35880845; rs12048407; rs3125647; rs12130328; rs3046950; rs12024163; rs7549484; rs12121831; rs35915510; rs12077141; rs10789506; rs2622906; rs12086199; rs34928345; rs34856862; rs11211525; rs4528158; rs7550999; rs35201142; rs36038736; rs28871045; rs12076263; rs3122609; rs12079592; rs7525552; rs10157734; rs4926832; rs2622904; rs2820987; rs12134888; rs6668250; rs10717198; rs12039270; rs34727473; rs7549485; rs3835609; rs11286214; rs4319382; rs3125642; rs10649132; rs34347262; rs12031601; rs2622907; rs34592236; rs2820988; rs12757893; rs12746766; rs12129259; rs6657172; rs34324996; rs11353905; rs34374399; rs35057132; rs34952704; rs35124142; rs11334963; rs12026822; rs12136812; rs2405918; rs3214951; rs34419291; rs34326568; rs34658109; rs34739143; rs35595628; rs10666791; rs2622905; rs12135037; rs11584578; rs28819073; rs3125645; rs12097707; rs10604027; rs12760270; rs12760379; rs11211516; rs11211526; rs12039726; rs12061831; rs12081669; rs12126139; rs12731806; rs12732050; rs17103165; rs17103168; rs17103179; rs17370337; rs17370386; rs17452995; rs2406105; rs2622923; rs2820980; rs3122618; rs3125635; rs3814003; rs6662189; rs6690084; rs7530285; rs7534571; rs9436874

# Metabolic_Enzyme_4_General_References:
10931946; 8313870; 1286669

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
6050

# Metabolic_Enzyme_5_Name:
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

# Metabolic_Enzyme_5_Synonyms:
Phosphatidylinositol synthase; PtdIns synthase; PI synthase

# Metabolic_Enzyme_5_Gene_Name:
CDIPT

# Metabolic_Enzyme_5_Protein_Sequence:
>CDPdiacylglycerolinositol 3phosphatidyltransferase
MPDENIFLFVPNLIGYARIVFAIISFYFMPCCPLTASSFYLLSGLLDAFDGHAARALNQG
TRFGAMLDMLTDRCSTMCLLVNLALLYPGATLFFQISMSLDVASHWLHLHSSVVRGSESH
KMIDLSGNPVLRIYYTSRPALFTLCAGNELFYCLLYLFHFSEGPLVGSVGLFRMGLWVTA
PIALLKSLISVIHLITAARNMAALDAADRAKKK

# Metabolic_Enzyme_5_Number_of_Residues:
213

# Metabolic_Enzyme_5_Molecular_Weight:
23539

# Metabolic_Enzyme_5_Theoretical_pI:
8.13

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  phospholipid metabolism
Process:  phospholipid biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme

# Metabolic_Enzyme_5_Pathway:
map00564  Glycerophospholipid metabolism;
 map04070  Phosphatidylinositol signaling system

# Metabolic_Enzyme_5_Reaction:
CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01066:CDP-OH_P_transf

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
6-26
29-49
76-96
140-160
175-195

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.7.8.11

# Metabolic_Enzyme_5_GenBank_ID_Protein:
2338732

# Metabolic_Enzyme_5_SwissProt_ID:
CDIPT_HUMAN (O14735)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
CDIPT

# Metabolic_Enzyme_5_Geneatlas_id:
CDIPT

# Metabolic_Enzyme_5_hgnc_id:
HGNC:1769

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein. Golgi apparatus; Golgi apparatus membrane; multi-pass membrane protein (By similarity). Cell membrane; multi-pass membrane protein (By similarity)

# Metabolic_Enzyme_5_Gene_Sequence:
>642 bp
ATGCCAGACGAAAATATCTTCCTGTTCGTGCCCAACCTCATCGGTTATGCCCGGATTGTC
TTCGCCATCATTTCTTTCTACTTCATGCCCTGCTGCCCCCTCACGGCCTCCTCCTTCTAC
CTGCTCAGCGGCCTGCTGGACGCTTTCGATGGACACGCTGCTCGCGCTCTTAATCAAGGA
ACCCGGTTTGGGGCCATGCTGGACATGCTGACGGACCGCTGCTCCACCATGTGCCTGTTG
GTCAACCTGGCCCTGCTGTACCCTGGAGCCACGCTGTTCTTCCAAATCAGCATGAGTTTG
GATGTGGCCAGTCACTGGCTGCACCTCCACAGTTCTGTGGTCCGAGGCAGTGAGAGTCAC
AAGATGATCGACTTGTCCGGGAATCCGGTGCTTCGGATCTACTACACCTCGAGGCCTGCT
CTGTTCACCTTGTGTGCTGGGAATGAGCTCTTCTACTGCCTCCTCTACCTGTTCCATTTC
TCTGAGGGACCTTTAGTTGGCTCTGTGGGACTGTTCCGGATGGGCCTCTGGGTCACTGCC
CCCATCGCCTTGCTGAAGTCGCTCATCAGCGTCATCCACCTGATCACGGCCGCCCGCAAC
ATGGCTGCCCTGGACGCAGCAGACCGCGCCAAGAAGAAGTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AF014807

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_5_Locus:
16p11.2

# Metabolic_Enzyme_5_SNPs:
rs1802002; rs17842263; rs8335; rs3815822; rs35042042; rs889695; rs747973; rs34121213; rs34794174; rs1802000; rs11540970; rs1802003; rs11540971; rs1801999; rs1802001; rs1801998; rs12597540; rs34248724; rs35676071; rs35434504; rs9929382; rs12917712; rs13338483; rs1559414; rs34504737; rs3764277; rs7201519; rs7204252; rs728832; rs9924348; rs9932926

# Metabolic_Enzyme_5_General_References:
9407135; 8110188

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5232

# Metabolic_Enzyme_6_Name:
Cytosolic 5'-nucleotidase 1B

# Metabolic_Enzyme_6_Synonyms:
Cytosolic 5'-nucleotidase IB; cN1B; cN-IB; Autoimmune infertility-related protein

# Metabolic_Enzyme_6_Gene_Name:
NT5C1B

# Metabolic_Enzyme_6_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
BMSQTSLKQKKNEPGMRSSKESLEAEKRKESDKTGVRLSNQMRRAVNPNHSLRCCPFQGH
SSCRRCLCAAEGTALGPCHTIRIYIHMCLLWEQGQQITMMRGSQESSLRKTDSRGYLVRS
QWSRISRSPSTKAPSIDEPRSRNTSAKLPSSSTSSRTPSTSPSLHDSSPPPLSGQPSLQP
PASPQLPRSLDSRPPTPPEPDPGSRRSTKMQENPEAWAQGIVREIRQTRDSQPLEYSRTS
PTEWKSSSQRRGIYPASTQLDRNSLSEQQQQQREDEDDYEAAYWASMRSFYEKNPSCSRP
WPPKPKNAITIALSSCALFNMVDGRKIYEQEGLEKYMEYQLTNENVILTPGPAFRFVKAL
QYVNARLRDLYPDEQDLFDIVLMTNNHAQVGVRLINSVNHYGLLIDRFCLTGGKDPIGYL
KAYLTNLYIAADSEKVQEAIQEGIASATMFDGAKDMAYCDTQLRVAFDGDAVLFSDESEH
FTKEHGLDKFFQYDTLCESKPLAQGPLKGFLEDLGRLQKKFYAKNERLLCPIRTYLVTAR
SAASSGARVLKTLRRWGLEIDEALFLAGAPKSPILVKIRPHIFFDDHMFHIEGAQRLGSI
AAYGFNKKFSS

# Metabolic_Enzyme_6_Number_of_Residues:
610

# Metabolic_Enzyme_6_Molecular_Weight:
68804

# Metabolic_Enzyme_6_Theoretical_pI:
9.03

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels

# Metabolic_Enzyme_6_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_6_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_6_GenBank_ID_Protein:
13774961

# Metabolic_Enzyme_6_SwissProt_ID:
5NT1B_HUMAN (Q96P26)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
NT5C1B

# Metabolic_Enzyme_6_Geneatlas_id:
NT5C1B

# Metabolic_Enzyme_6_hgnc_id:
HGNC:17818

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_6_Gene_Sequence:
>1699 bp
GGGCAAAAATGTGGATAACAACAAAAGAATTTCAACAGGTAAAAAAATGAGTCAAACATC
TCTCAAACAGAAAAAGAATGAGCCCGGAATGAGGTCCTCAAAAGAGAGTCTAGAAGCAGA
AAAAAGAAAGGAATCTGACAAAACAGGAGTTCGTCTGAGCAATCAGGGATCACAAGAATC
ATCACTGCGGAAGACAGACTCTCGAGGGTACCTTGTGCGCAGTCAATGGTCTAGAATATC
CCGGAGCCCATCCACCAAGGCTCCATCCATAGATGAGCCTAGAAGCAGGAACACCAGTGC
TAAGCTCCCCAGCAGCTCCACGAGCTCCCGGACTCCATCCACCTCCCCAAGCCTGCATGA
CTCCTCACCGCCGCCGCTGTCCGGGCAGCCCTCGCTCCAGCCACCCGCGTCGCCCCAGCT
GCCCCGGTCGCTGGACTCGCGGCCTCCCACGCCCCCAGAGCCCGATCCTGGCTCCCGGCG
CAGCACCAAAATGCAAGAAAATCCGGAGGCCTGGGCCCAAGGCATCGTGCGGGAAATCCG
CCAGACCCGGGACTCGCAGCCGCTGGAATATTCGCGCACGTCCCCCACCGAGTGGAAGTC
CTCCAGCCAGCGCAGGGGGATCTACCCCGCCTCCACCCAGCTGGACCGCAACTCTCTGTC
CGAGCAGCAGCAGCAGCAGCGGGAGGACGAAGACGACTACGAAGCTGCCTACTGGGCATC
CATGAAGTCGTTCTACGAAAAGAACCCGAGCTGCTGGCGCCCCTGGCCGCCCAAACCCAA
GAACGCCATCACCATTGCTCTCTCATCCTGCGCGCTCTTCAACATGGTGGACGGCAGGAA
AATCTACGAGCAAGAGGGTCTGGAAAAGTACATGGAGTATCAGCTCACCAATGAGAACGT
CATCCTGACCCCGGGCCCGGCGTTCCGTTTCGTCAAGGCACTACAGTATGTCAATGCTAG
ACTCCGTGATCTATATCCTGATGAACAGGACTTATTTGATATTGTACTGATGACTAATAA
CCATGCCCAAGTGGGAGTGCGGCTTATAAACAGCGTCAATCACTACGGCTTACTGATTGA
CCGCTTCTGTCTGACCGGGGGAAAAGACCCCATTGGCTATTTGAAGGCATATCTTACCAA
CTTGTATATTGCTGCAGATTCTGAAAAAGTGCAAGAGGCAATACAAGAAGGTATTGCCTC
TGCGACAATGTTTGATGGAGCCAAAGACATGGCTTACTGTGACACTCAGCTCCGTGTAGC
CTTTGATGGGGATGCTGTCCTCTTCTCTGATGAGTCTGAACATTTTACCAAGGAGCATGG
GCTGGACAAATTCTTCCAGTATGATACATTATGTGAAAGTAAGCCTCTTGCTCAGGGTCC
CCTAAAAGGCTTTCTGGAAGATTTAGGCAGACTGCAAAAGAAGTTCTATGCCAAAAATGA
ACGGTTACTTTGTCCTATCAGGACCTACCTGGTTACAGCTAGGAGTGCAGCCAGTTCAGG
CGCCCGTGTGCTGAAAACCTTCCGACGCTGGGGTCTAGAGATAGACGAAGCTCTTTTCCT
TGCTGGAGCCCCCAAAAGTCCCATCTTGGTGAAGATCCGGCCCCACATCTTCTTTGATGA
CCACATGTTCCACATTGAAGGGGCACAGAGGTTAGGTTCCATCGCAGCTTATGGCTTTAA
TAAAAAATTCAGTAGTTAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AF356185

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_6_Locus:
2p24.2

# Metabolic_Enzyme_6_SNPs:
rs3902946; rs16985301; rs16985306; rs3747660; rs2346137; rs6720633; rs7594728; rs6531109; rs6710367; rs7557821; rs4832608; rs11893074; rs16985296; rs7561652; rs2317857; rs16985292; rs16985290; rs6741218; rs11096544; rs35590292; rs10183289; rs17752103; rs11885013; rs17701334; rs16985293; rs11903725; rs7604190; rs4832609; rs7592099; rs16985311; rs16985310; rs3810839; rs17852342; rs34254789; rs7594519; rs34129467; rs7605480; rs35165251; rs7603601; rs34836771; rs34186303; rs35711606; rs35729409; rs34953851; rs11291136; rs28474708; rs3046807; rs34660980; rs35519366; rs3046840; rs35419885; rs7557722; rs4300829; rs7592233; rs13020403; rs36121694; rs34127788; rs11889898; rs13403096; rs13411442; rs1373776; rs16985281; rs16985284; rs17751951; rs2346135; rs2346136; rs34722188; rs35805648; rs3810838; rs3910894

# Metabolic_Enzyme_6_General_References:
11690631

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5234

# Metabolic_Enzyme_7_Name:
5'(3')-deoxyribonucleotidase, cytosolic type

# Metabolic_Enzyme_7_Synonyms:
Cytosolic 5',3'-pyrimidine nucleotidase; Deoxy-5'-nucleotidase 1; dNT-1

# Metabolic_Enzyme_7_Gene_Name:
NT5C

# Metabolic_Enzyme_7_Protein_Sequence:
>5'3'deoxyribonucleotidase, cytosolic type
MARSVRVLVDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADK
VASVYEAPGFFLDLEPIPGALDAVREMNDLPDTQVFICTSPLLKYHHCVGEKYRWVEQHL
GPQFVERIILTRDKTVVLGDLLIDDKDTVRGQEETPSWEHILFTCCHNRHLVLPPTRRRL
LSWSDNWREILDSKRGAAQRE

# Metabolic_Enzyme_7_Number_of_Residues:
201

# Metabolic_Enzyme_7_Molecular_Weight:
23383

# Metabolic_Enzyme_7_Theoretical_pI:
6.63

# Metabolic_Enzyme_7_GO_Classification:
Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
Not Available

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_7_GenBank_ID_Protein:
7524492

# Metabolic_Enzyme_7_SwissProt_ID:
NT5C_HUMAN (Q8TCD5)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
NT5C

# Metabolic_Enzyme_7_Geneatlas_id:
NT5C

# Metabolic_Enzyme_7_hgnc_id:
HGNC:17144

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_7_Gene_Sequence:
>606 bp
ATGGCGCGGAGCGTGCGCGTGCTGGTGGACATGGACGGCGTCCTGGCCGACTTCGAGGCC
GGCCTCCTGCGGGGCTTCCGCCGCCGCTTCCCTGAGGAGCCGCACGTGCCGCTGGAGCAA
CGCCGCGGCTTCCTGGCCCGCGAGCAGTACCGCGCCCTGCGGCCCGACCTGGCGGATAAA
GTGGCCAGTGTGTACGAAGCCCCGGGCTTTTTCCTGGACCTGGAGCCCATCCCGGGAGCC
TTGGACGCTGTGCGGGAGATGAACGACCTACCGGACACGCAGGTCTTCATCTGCACCAGC
CCCCTGCTGAAGTACCACCACTGTGTGGGTGAGAAGTACCGCTGGGTGGAGCAGCACCTG
GGGCCCCAGTTCGTAGAACGAATTATCCTGACAAGGGACAAGACGGTGGTCTTGGGGGAC
CTGCTCATTGATGACAAGGACACAGTTCGAGGCCAGGAGGAGACCCCAAGCTGGGAGCAC
ATCTTGTTCACCTGCTGCCACAATCGGCACCTGGTCCTGCCCCCGACAAGGAGACGGCTG
CTCTCCTGGAGTGACAACTGGAGGGAGATCTTAGATAGCAAGCGCGGAGCTGCGCAGCGG
GAATGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AF154829

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_7_Locus:
17q25.1

# Metabolic_Enzyme_7_SNPs:
rs4788867; rs11868451; rs3736076; rs3736075; rs12453556; rs4789144; rs11652099; rs4789143; rs11541956; rs12945569; rs3188816; rs12946860; rs1048779; rs12943507; rs34746270; rs11541955; rs12945517; rs9910084; rs34454120; rs7406461; rs4788868; rs11868212; rs1551966; rs2291027; rs2291028; rs34338273; rs3752801; rs4412997; rs4789145; rs750843; rs750844; rs899316; rs899317

# Metabolic_Enzyme_7_General_References:
10681516; 12234672

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
6051

# Metabolic_Enzyme_8_Name:
Lactosylceramide alpha-2,3-sialyltransferase

# Metabolic_Enzyme_8_Synonyms:
CMP- NeuAc:lactosylceramide alpha-2,3-sialyltransferase; Ganglioside GM3 synthase; ST3Gal V; Sialyltransferase 9

# Metabolic_Enzyme_8_Gene_Name:
ST3GAL5

# Metabolic_Enzyme_8_Protein_Sequence:
>Lactosylceramide alpha2,3sialyltransferase
MRRPSLLLKDILKCTLLVFGVWILYILKLNYTTEECDMKKMHYVDPDHVKRAQKYAQQVL
QKECRPKFAKTSMALLFEHRYSVDLLPFVQKAPKDSEAESKYDPPFGFRKFSSKVQTLLE
LLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGN
KTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVA
EKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEV
SLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKLVKEGVVKDLSGGIDR
EF

# Metabolic_Enzyme_8_Number_of_Residues:
362

# Metabolic_Enzyme_8_Molecular_Weight:
41736

# Metabolic_Enzyme_8_Theoretical_pI:
8.62

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  sialyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  intrinsic to organelle membrane
Component:  intrinsic to Golgi membrane
Component:  integral to Golgi membrane

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D- glucosylceramide)

# Metabolic_Enzyme_8_Pathway:
map00604  Ganglioside biosynthesis

# Metabolic_Enzyme_8_Reaction:
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00777:Glyco_transf_29

# Metabolic_Enzyme_8_Signals:
1-32

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.4.99.9

# Metabolic_Enzyme_8_GenBank_ID_Protein:
3779139

# Metabolic_Enzyme_8_SwissProt_ID:
SIAT9_HUMAN (Q9UNP4)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
ST3GAL5

# Metabolic_Enzyme_8_Geneatlas_id:
ST3GAL5

# Metabolic_Enzyme_8_hgnc_id:
HGNC:10872

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Potential)

# Metabolic_Enzyme_8_Gene_Sequence:
>1089 bp
ATGAGAAGGCCCAGCTTGTTATTAAAAGACATCCTCAAATGTACATTGCTTGTGTTTGGA
GTGTGGATCCTTTATATCCTCAAGTTAAATTATACTACTGAAGAATGTGACATGAAAAAA
ATGCATTATGTGGACCCTGACCGTGTAAAGAGAGCTCAGAAATATGCTCAGCAAGTCTTG
CAGAAGGAATGTCGTCCCAAGTTTGCCAAGACATCAATGGCGCTGTTATTTGAGCACAGG
TATAGCGTGGACTTACTCCCTTTTGTGCAGAAGGCCCCCAAAGACAGTGAAGCTGAGTCC
AAGTACGATCCTCCTTTTGGGTTCCGGAAGTTCTCCAGTAAAGTCCAGACCCTCTTGGAA
CTCTTGCCAGAGCACGACCTCCCTGAACACTTGAAAGCCAAGACCTGTCGGCGCTGTGTG
GTTATTGGAAGCGGAGGAATACTGCACGGATTAGAACTGGGCCACACCCTGAACCAGTTC
GATGTTGTGATAAGGTTAAACAGTGCACCAGTTGAGGGATATTCAGAACATGTTGGAAAT
AAAACTACTATAAGGATGACTTATCCAGAGGGCGCACCACTGTCTGACCTTGAATATTAT
TCCAATGACTTATTTGTTGCTGTTTTATTTAAGAGTGTTGATTTCAACTGGCTTCAAGCA
ATGGTAAAAAAGGAAACCCTGCCATTCTGGGTACGACTCTTCTTTTGGAAGCAGGTGGCA
GAAAAAATCCCACTGCAGCCAAAACATTTCAGGATTTTGAATCCAGTTATCATCAAAGAG
ACTGCCTTTGACATCCTTCAGTACTCAGAGCCTCAGTCAAGGTTCTGGGGCCGAGATAAG
AACGTCCCCACAATCGGTGTCATTGCCGTTGTCTTAGCCACACATCTGTGCGATGAAGTC
AGTTTGGCGGGTTTTGGATATGACCTCAATCAACCCAGAACACCTTTGCACTACTTCGAC
AGTCAATGCATGGCTGCTATGAACTTTCAGACCATGCATAATGTGACAACGGAAACCAAG
TTCCTCTTAAAGCTGGTCAAAGAGGGAGTGGTGAAAGATCTCAGTGGAGGCATTGATCGT
GAATTTTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
AB018356

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_8_Locus:
2p11.2

# Metabolic_Enzyme_8_SNPs:
rs3731824; rs2030275; rs4832211; rs11681961; rs4553826; rs1533605; rs4832213; rs4832015; rs6734488; rs1878904; rs6547636; rs6547635; rs17026728; rs11674097; rs11689889; rs12622987; rs12614498; rs6750686; rs6721125; rs6753350; rs6547638; rs11681915; rs3810821; rs2366948; rs10865479; rs6547637; rs12714153; rs11127009; rs10175609; rs12618873; rs1518991; rs6751743; rs6720161; rs6547639; rs10865480; rs7587003; rs13422640; rs12463901; rs1878905; rs4832215; rs17026729; rs10204648; rs11127008; rs7565996; rs6547640; rs4832016; rs11694341; rs6707472; rs11687628; rs6720628; rs11127006; rs11678865; rs1518990; rs1054936; rs3770094; rs13020072; rs4832210; rs12613609; rs6753528; rs10496319; rs7561062; rs2280316; rs10203518; rs6716233; rs2366947; rs6547634; rs2280315; rs3770093; rs12990400; rs2280314; rs3770092; rs17026675; rs13028295; rs13025142; rs7572209; rs10496320; rs17026684; rs13014890; rs3770096; rs17026666; rs11694145; rs13014421; rs10179419; rs6759239; rs7558479; rs3770097; rs17026701; rs12478916; rs11679283; rs2176627; rs1000374; rs12714154; rs4832216; rs28364795; rs11127001; rs11127002; rs28364794; rs11674561; rs34172834; rs34410645; rs11894301; rs35521726; rs11893440; rs11127005; rs13025122; rs34467025; rs35974858; rs10698508; rs4432451; rs13024999; rs11891682; rs11298476; rs35899858; rs11127004; rs35912129; rs3046644; rs3202465; rs10693806; rs35093099; rs35327098; rs35628812; rs33930859; rs7600473; rs34207983; rs11127007; rs1533606; rs36072743; rs11127003; rs7586816; rs35466870; rs4446072; rs34120521; rs13016226; rs4832214; rs13024577; rs11893589; rs35528159; rs34584624; rs13024553; rs10553932; rs34971291; rs35268429; rs12992339; rs34082565; rs34403285; rs13033743; rs35487160; rs34896754; rs35817943; rs2280313; rs13191; rs10696470; rs35707118; rs3046619; rs35493914; rs34292806; rs34737048; rs35086875; rs9677117; rs35477883; rs36008111; rs35483582; rs3046643; rs34980443; rs2280312; rs12997361; rs35921749; rs13007131; rs13015450; rs35844245; rs41291145; rs36078405; rs13014513; rs10696471; rs5832664; rs35683772; rs13034643; rs11674537; rs10171816; rs10175249; rs11683466; rs13031939; rs13420465; rs1401383; rs1401385; rs1543972; rs1607466; rs1878898; rs2139201; rs2366949; rs2438307; rs4832217; rs6726662; rs6735629; rs7572585; rs954176

# Metabolic_Enzyme_8_General_References:
9822625; 12975309

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5503

# Metabolic_Enzyme_9_Name:
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

# Metabolic_Enzyme_9_Synonyms:
Ganglioside GD3 synthase; Ganglioside GT3 synthase; Alpha-2,8- sialyltransferase 8A; ST8Sia I

# Metabolic_Enzyme_9_Gene_Name:
ST8SIA1

# Metabolic_Enzyme_9_Protein_Sequence:
>AlphaNacetylneuraminide alpha2,8sialyltransferase
MSPCGRARRQTSRGAMAVLAWKFPRTRLPMGASALCVVVLCWLYIFPVYRLPNEKEIVQG
VLQQGTAWRRNQTAARAFRKQMEDCCDPAHLFAMTKMNSPMGKSMWYDGEFLYSFTIDNS
TYSLFPQATPFQLPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSEYTKDVGS
KSQLVTANPSIIRQRFQNLLWSRKTFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLS
DVGANQTVLFANPNFLRSIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFSV
NMHEQPISHHYYDNVLPFSGFHAMPEEFLQLWYLHKIGALRMQLDPCEDTSLQPTS

# Metabolic_Enzyme_9_Number_of_Residues:
356

# Metabolic_Enzyme_9_Molecular_Weight:
40519

# Metabolic_Enzyme_9_Theoretical_pI:
9.61

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  sialyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  intrinsic to organelle membrane
Component:  intrinsic to Golgi membrane
Component:  integral to Golgi membrane

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
Involved in the production of GD3 and GT3 from GM3

# Metabolic_Enzyme_9_Pathway:
map00602  Blood group glycolipid biosynthesis-neolactoseries;
 map00603  Globoside metabolism;
 map00604  Ganglioside biosynthesis

# Metabolic_Enzyme_9_Reaction:
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00777:Glyco_transf_29

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
30-48

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.4.99.8

# Metabolic_Enzyme_9_GenBank_ID_Protein:
662254

# Metabolic_Enzyme_9_SwissProt_ID:
SIA8A_HUMAN (Q92185)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
ST8SIA1

# Metabolic_Enzyme_9_Geneatlas_id:
ST8SIA1

# Metabolic_Enzyme_9_hgnc_id:
HGNC:10869

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Potential)

# Metabolic_Enzyme_9_Gene_Sequence:
>1026 bp
ATGGCTGTACTGGCGTGGAAGTTCCCGCGGACCCGGCTGCCCATGGGAGCCAGTGCCCTC
TGTGTCGTGGTCCTCTGTTGGCTCTACATCTTCCCCGTCTACCGGCTGCCCAACGAGAAA
GAGATCGTGCAGGGGGTGCTGCAACAGGGCACGGCGTGGAGGAGGAACCAGACCGCGGCC
AGAGCGTTCAGGAAACAAATGGAAGACTGCTGCGACCCTGCCCATCTCTTTGCTATGACT
AAAATGAATTCCCCTATGGGGAAGAGCATGTGGTATGACGGGGAGTTTTTATACTCATTC
ACCATTGACAATTCAACTTACTCTCTCTTCCCACAGGCAACCCCATTCCAGCTGCCATTG
AAGAAATGCGCGGTGGTGGGAAATGGTGGGATTCTGAAGAAGAGTGGCTGTGGCCGTCAA
ATAGATGAAGCAAATTTTGTCATGCGATGCAATCTCCCTCCTTTGTCAAGTGAATACACT
AAGGATGTTGGATCCAAAAGTCAGTTAGTGACAGCTAATCCCAGCATAATTCGGCAAAGG
TTTCAGAACCTTCTGTGGTCCAGAAAGACATTTGTGGACAACATGAAAATTTATAACCAC
AGTTACATCTACATGCCTGCCTTTTCTATGAAGACAGGAACAGAGCCATCTTTGAGGGTT
TATTATACACTGTCAGATGTTGGTGCCAATCAAACAGTGCTGTTTGCCAACCCCAACTTT
CTGCGTAGCATTGGAAAGTTCTGGAAAAGTAGAGGAATCCATGCCAAGCGCCTGTCCACA
GGACTTTTTCTGGTGAGCGCAGCTCTGGGTCTCTGTGAAGAGGTGGCCATCTATGGCTTC
TGGCCCTTCTCTGTGAATATGCATGAGCAGCCCATCAGCCACCACTACTATGACAACGTC
TTACCCTTTTCTGGCTTCCATGCCATGCCCGAGGAATTTCTCCAACTCTGGTATCTTCAT
AAAATCGGTGCACTGAGAATGCAGCTGGACCCATGTGAAGATACCTCACTCCAGCCCACT
TCCTAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
L32867

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_9_Locus:
12p12.1-p11.2

# Metabolic_Enzyme_9_SNPs:
rs704219; rs3803101; rs1803638; rs918099; rs1558793; rs1861606; rs2900502; rs2728824; rs2300715; rs1019332; rs2017107; rs2728829; rs2300718; rs2041906; rs2300726; rs2728825; rs2728822; rs2300717; rs2541300; rs2728827; rs1362601; rs2300739; rs1155392; rs11615329; rs2193180; rs2300728; rs4762892; rs1987940; rs2300721; rs2728821; rs3782524; rs2300738; rs11614265; rs1345412; rs2300725; rs11046348; rs7134252; rs722248; rs2012936; rs7312306; rs2728818; rs2284849; rs2300729; rs12828366; rs2111177; rs11046351; rs6487295; rs11608373; rs11046344; rs976709; rs2160536; rs1160783; rs4762894; rs734554; rs3819868; rs7301632; rs4762898; rs4762901; rs7963388; rs2193178; rs10459079; rs7970824; rs7958065; rs4762895; rs2300735; rs10770899; rs2300731; rs2728826; rs4762904; rs7297765; rs976710; rs2541303; rs2216228; rs10841976; rs1014433; rs11611833; rs3819878; rs16924749; rs1019331; rs17703131; rs1158409; rs741371; rs2268857; rs12310364; rs2284854; rs2012722; rs7953875; rs10841978; rs759530; rs12813971; rs1420630; rs7310117; rs11830582; rs11838002; rs10841979; rs2728828; rs2300712; rs11610532; rs11046350; rs10841986; rs12310517; rs4133369; rs4762896; rs2300719; rs10841984; rs9919724; rs16924828; rs2072542; rs2541299; rs741370; rs12099876; rs1960265; rs7966606; rs17704613; rs7314460; rs16924859; rs12297315; rs7316302; rs12302876; rs2268858; rs2268861; rs741369; rs2193179; rs11611999; rs7307161; rs2418055; rs2287169; rs10841983; rs11833651; rs2728817; rs12826088; rs16924844; rs11836129; rs2012613; rs2300737; rs3782525; rs11046355; rs10492282; rs3782526; rs7956389; rs2300732; rs16924767; rs17653452; rs11613665; rs2284853; rs10841982; rs2541302; rs12310040; rs7132895; rs2016977; rs2193177; rs11614453; rs4098994; rs2418057; rs10841977; rs7307537; rs16924832; rs7962240; rs12321356; rs2216227; rs7311793; rs11610434; rs2900501; rs11613227; rs12825106; rs10492283; rs2300740; rs11611401; rs2300727; rs17646466; rs11832631; rs7296325; rs1345413; rs10841987; rs17646831; rs10841974; rs11834129; rs7311007; rs10841980; rs7964012; rs7132027; rs11837885; rs11612221; rs4762899; rs2541301; rs11612147; rs11046353; rs2300720; rs12815461; rs7295402; rs3819873; rs16924898; rs11612801; rs2284848; rs12823181; rs2268856; rs11613477; rs11835023; rs2541298; rs2300716; rs2300734; rs2728823; rs7971462; rs7312773; rs2287166; rs2216229; rs11613570; rs7956659; rs10047668; rs12321369; rs12815963; rs7956227; rs6487297; rs12314813; rs16924777; rs3819867; rs12301177; rs7959390; rs17702101; rs981884; rs976711; rs16924864; rs7311021; rs2728820; rs16924880; rs34312316; rs4325353; rs10841973; rs12315759; rs2284852; rs3819879; rs16924850; rs12309232; rs16924787; rs2300733; rs11608405; rs12818857; rs7962800; rs7960627; rs2300722; rs16924821; rs12820379; rs11046367; rs7965135; rs17702788; rs12813030; rs11611356; rs2418058; rs2193181; rs16924854; rs16924866; rs2216230; rs12817074; rs16924815; rs9739131; rs7976824; rs3819866; rs7978882; rs10841975; rs4762739; rs16924858; rs16924758; rs1420629; rs2300714; rs2287168; rs35947550; rs2098412; rs7310760; rs7297807; rs12317347; rs12826736; rs12815085; rs6487296; rs3825254; rs2216231; rs2300723; rs16924835; rs7296627; rs12828939; rs7298767; rs3819865; rs1420627; rs17702940; rs17645440; rs7953421; rs2300736; rs3819872; rs741368; rs11046347; rs12816677; rs7312718; rs2300713; rs16924857; rs17653482; rs12827101; rs11046357; rs1985103; rs12303299; rs7135998; rs2728819; rs3782523; rs7294520; rs7961947; rs1420628; rs2287167; rs35486967; rs7487656; rs7977156; rs12824390; rs3819877; rs10841981; rs7488721; rs7306930; rs11609191; rs741373; rs11046362; rs10841985; rs4762737; rs7970051; rs3809201; rs12815906; rs12318055; rs10841972; rs3809202; rs35306551; rs35744997; rs12581522; rs12581521; rs3819874; rs12826179; rs12817086; rs11367158; rs34136037; rs34811401; rs34647249; rs35183171; rs3831855; rs10642644; rs2728830; rs10671911; rs34724709; rs35361835; rs35911569; rs11448343; rs11837717; rs12826536; rs34425903; rs36083303; rs3216628; rs12309948; rs10622751; rs34476732; rs5796958; rs11046363; rs35831712; rs2300730; rs12318036; rs36111754; rs12424706; rs12822143; rs12582926; rs34967112; rs36114533; rs34756870; rs12827903; rs35692052; rs3837484; rs34151958; rs2098411; rs10609876; rs34822376; rs7485100; rs35038009; rs34575551; rs2193175; rs35580365; rs35972980; rs12822313; rs12826833; rs5796954; rs3819871; rs28729097; rs12301178; rs7311722; rs11046364; rs11463657; rs7970420; rs11046356; rs4762738; rs35850622; rs11349014; rs3216630; rs11394293; rs3819875; rs12822646; rs12822153; rs35943365; rs5796955; rs34867244; rs35394244; rs35116949; rs34447515; rs35522704; rs3819869; rs12319691; rs12816254; rs35764423; rs12812546; rs4762902; rs34820200; rs12822460; rs3216629; rs9919816; rs12822607; rs35335972; rs34854158; rs34852606; rs34707453; rs11046359; rs4762897; rs12818405; rs34027017; rs35707838; rs11290260; rs35848576; rs34935354; rs11352285; rs11046345; rs12826523; rs34553797; rs35291474; rs10634712; rs34341619; rs11502698; rs4762905; rs34992184; rs12822323; rs35516385; rs12298017; rs1012675; rs3940333; rs34168353; rs35021216; rs35395680; rs12812044; rs3063800; rs12372480; rs35058755; rs35934031; rs2418056; rs11046352; rs10673826; rs11434182; rs35021352; rs35504356; rs10718948; rs35961342; rs34353400; rs2268860; rs12826918; rs34637155; rs11046346; rs35362312; rs5796956; rs7965003; rs7138635; rs35849391; rs918100; rs34095117; rs11046354; rs34090928; rs35543851; rs35109127; rs34593544; rs11046358; rs2955522; rs3063802; rs3819876; rs3216631; rs34518605; rs2268859; rs2728816; rs12827371; rs34371745; rs5796957; rs12819073; rs34578656; rs7965977; rs34415112; rs34650104; rs34954149; rs34136511; rs34056487; rs11046366; rs34181694; rs7956051; rs7303005; rs35307715; rs35109397; rs34769711; rs4366539; rs34653517; rs35698287; rs11421261; rs17703173; rs5796953; rs3216627; rs34119935; rs12822647; rs3819870; rs35002189; rs11423875; rs34617030; rs3063795; rs12579498; rs2300724; rs35794118; rs2193176; rs12811237; rs11336297; rs734555; rs11046360; rs9919725; rs35520367; rs34802684; rs3944006; rs7978750; rs35900702; rs2284857; rs11361771; rs34395687; rs35520685; rs34377192; rs34617658; rs3831856; rs7316093; rs7956855; rs35988676; rs35594380; rs10459078; rs10841988; rs11046340; rs12308957; rs12816719; rs16924743; rs2160631; rs2193380; rs2418054; rs4606528

# Metabolic_Enzyme_9_General_References:
7937974; 8058740; 8631981; 8195250

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
6052

# Metabolic_Enzyme_10_Name:
Type 2 lactosamine alpha-2,3-sialyltransferase

# Metabolic_Enzyme_10_Synonyms:
CMP- NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI; ST3Gal VI; Sialyltransferase 10

# Metabolic_Enzyme_10_Gene_Name:
ST3GAL6

# Metabolic_Enzyme_10_Protein_Sequence:
>Type 2 lactosamine alpha2,3sialyltransferase
MRGYLVAIFLSAVFLYYVLHCILWGTNVYWVAPVEMKRRNKIQPCLSKPAFASLLRFHQF
HPFLCAADFRKIASLYGSDKFDLPYGMRTSAEYFRLALSKLQSCDLFDEFDNIPCKKCVV
VGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDP
NTTVILTAFKPHDLRWLLELLMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYE
LLHFPKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSL
MNKNAYHNVTAEQLFLKDIIEKNLVINLTQD

# Metabolic_Enzyme_10_Number_of_Residues:
331

# Metabolic_Enzyme_10_Molecular_Weight:
38214

# Metabolic_Enzyme_10_Theoretical_pI:
9.30

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  sialyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  intrinsic to organelle membrane
Component:  intrinsic to Golgi membrane
Component:  integral to Golgi membrane

# Metabolic_Enzyme_10_General_Function:
Not Available

# Metabolic_Enzyme_10_Specific_Function:
Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1

# Metabolic_Enzyme_10_Pathway:
Not Available

# Metabolic_Enzyme_10_Reaction:
Not Available

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00777:Glyco_transf_29

# Metabolic_Enzyme_10_Signals:
1-25

# Metabolic_Enzyme_10_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.4.99.10

# Metabolic_Enzyme_10_GenBank_ID_Protein:
4827247

# Metabolic_Enzyme_10_SwissProt_ID:
SIA10_HUMAN (Q9Y274)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
ST3GAL6

# Metabolic_Enzyme_10_Geneatlas_id:
ST3GAL6

# Metabolic_Enzyme_10_hgnc_id:
HGNC:18080

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Potential)

# Metabolic_Enzyme_10_Gene_Sequence:
>996 bp
ATGAGAGGGTATCTTGTGGCCATATTCCTGAGTGCTGTCTTCCTCTATTATGTACTGCAT
TGCATATTATGGGGAACGAATGTCTATTGGGTGGCACCTGTGGAAATGAAACGGAGAAAT
AAGATCCAGCCTTGTTTATCAAAGCCAGCTTTTGCCTCTCTGCTGAGGTTTCATCAGTTT
CACCCTTTTCTGTGTGCGGCTGATTTTAGAAAGATTGCTTCCTTGTATGGTAGCGATAAG
TTTGATTTGCCCTATGGGATGAGAACATCAGCGGAATATTTTCGACTTGCTCTTTCAAAA
CTGCAGAGTTGTGATCTCTTTGATGAGTTTGACAACATACCCTGTAAAAAGTGTGTGGTG
GTTGGTAATGGAGGAGTTTTGAAGAATAAGACATTAGGAGAAAAAATCGACTCCTATGAT
GTAATAATAAGAATGAATAATGGTCCTGTTTTAGGACATGAAGAAGAAGTTGGGAGAAGG
ACAACCTTCCGACTTTTTTATCCAGAATCTGTTTTTTCAGATCCTATTCACAATGACCCT
AATACGACAGTGATTCTCACTGCTTTTAAGCCACATGATTTAAGGTGGCTGTTGGAATTG
TTGATGGGTGACAAAATAAACACTAATGGTTTTTGGAAGAAACCAGCCTTAAACCTGATT
TATAAACCTTATCAAATCCGAATATTAGATCCTTTCATTATCAGAACAGCAGCTTATGAA
CTGCTTCATTTTCCAAAAGTGTTTCCCAAAAATCAGAAACCTAAACACCCAACAACAGGA
ATTATTGCCATCACATTGGCGTTTTACATATGTCACGAAGTTCACCTAGCTGGTTTTAAA
TACAACTTTTCTGACCTCAAGAGTCCTTTGCACTACTATGGGAATGCCACCATGTCTTTG
ATGAATAAGAACGCGTATCACAATGTGACTGCAGAGCAGCTCTTTTTGAAGGACATTATA
GAAAAAAACCTCGTAATCAACTTGACTCAAGATTGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
AB022918

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_10_Locus:
3q12.1

# Metabolic_Enzyme_10_SNPs:
rs28489284; rs828595; rs1530655; rs828598; rs3821358; rs278370; rs278374; rs704580; rs828599; rs278373; rs828596; rs828600; rs9879927; rs278372; rs844161; rs278371; rs115931; rs7634817; rs828597; rs278365; rs4638909; rs1440149; rs3772091; rs828602; rs828591; rs9832986; rs828613; rs893831; rs828594; rs3213958; rs893832; rs6783640; rs1666310; rs3772090; rs11925547; rs4488775; rs14310; rs2028392; rs11915622; rs3841917; rs828593; rs1036675; rs10470451; rs1440153; rs278376; rs828610; rs828608; rs6804850; rs9811305; rs4426625; rs2334230; rs2919235; rs999147; rs3755574; rs828609; rs3772099; rs4426626; rs1440152; rs9883516; rs7611929; rs7431448; rs3821359; rs3755573; rs9811449; rs3755576; rs2919234; rs17270593; rs3772097; rs4425200; rs16840147; rs278390; rs2290067; rs2278599; rs9883537; rs16846347; rs4494869; rs9872152; rs4425201; rs7612036; rs9870500; rs12107050; rs11914715; rs3772101; rs844160; rs6790650; rs6808116; rs704585; rs9866570; rs1440151; rs9855175; rs828605; rs12108142; rs9878392; rs16840150; rs34951301; rs9815226; rs828604; rs3755575; rs3772098; rs278375; rs3772100; rs12490832; rs828611; rs17210963; rs166764; rs12330170; rs828603; rs9862660; rs3772102; rs9855983; rs6782630; rs13091236; rs3755569; rs278385; rs3755570; rs7653328; rs34064986; rs10526947; rs34040814; rs34523669; rs828612; rs35302662; rs10620991; rs11326863; rs34382949; rs10619876; rs11300353; rs34468318; rs34667052; rs36011922; rs35831456; rs5851136; rs35769190; rs13059993; rs2439219; rs3836213; rs2442070; rs3772087; rs35744064; rs35680837; rs28707457; rs35581339; rs12635283; rs11379768; rs28553326; rs7614161; rs1345184; rs36122265; rs828590; rs10470452; rs5851135; rs1125299; rs11923134; rs35649214; rs3217579; rs13093435; rs11336641; rs36045157; rs34993293; rs28810772; rs34557543; rs35099205; rs35449080; rs828592; rs3772095; rs13066243; rs35800676; rs13094768; rs2196884; rs35251261; rs13091048; rs13085913; rs4607047; rs34519152; rs13094769; rs34730845; rs11378376; rs35085649; rs3836214; rs35352162; rs33926054; rs13060012; rs11350859; rs34166480; rs35205112; rs9859535; rs13080057; rs28429424; rs10706567; rs35668734; rs11305556; rs35377255; rs34177093; rs11445870; rs35010405; rs34606352; rs34947081; rs4395349; rs41267851; rs2290068; rs10576193; rs9839408; rs33936420; rs34588217; rs10703375; rs3214776; rs34254953; rs10612845; rs35481801; rs5851138; rs278389; rs34470469; rs10621099; rs3772096; rs10704396; rs3834180; rs13072410; rs10620090; rs35917234; rs5851137; rs36191987; rs36013913; rs35913380; rs13060721; rs10546771; rs10675954; rs36205313; rs35970088; rs10546770; rs1058732; rs1062196; rs1062197; rs11552978; rs11927749; rs12054306; rs12203; rs1440155; rs16840208; rs17270986; rs1822017; rs1866679; rs1868217; rs278369; rs278384; rs3796133; rs5016847; rs6780097; rs6780169; rs704586; rs7611040; rs7628381; rs828589; rs828607; rs844159; rs865474; rs8833; rs9839559; rs9842747

# Metabolic_Enzyme_10_General_References:
10206952

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5229

# Metabolic_Enzyme_11_Name:
5'-nucleotidase precursor

# Metabolic_Enzyme_11_Synonyms:
Ecto-5'-nucleotidase; 5'-NT; CD73 antigen

# Metabolic_Enzyme_11_Gene_Name:
NT5E

# Metabolic_Enzyme_11_Protein_Sequence:
>5'nucleotidase precursor
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ

# Metabolic_Enzyme_11_Number_of_Residues:
574

# Metabolic_Enzyme_11_Molecular_Weight:
63368

# Metabolic_Enzyme_11_Theoretical_pI:
7.04

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  hydrolase activity, acting on ester bonds
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides

# Metabolic_Enzyme_11_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_11_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF02872:5_nucleotid_C;
PF00149:Metallophos

# Metabolic_Enzyme_11_Signals:
1-26

# Metabolic_Enzyme_11_Transmembrane_Regions:
556-573

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_11_GenBank_ID_Protein:
23897

# Metabolic_Enzyme_11_SwissProt_ID:
5NTD_HUMAN (P21589)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
NT5E

# Metabolic_Enzyme_11_Geneatlas_id:
NT5E

# Metabolic_Enzyme_11_hgnc_id:
HGNC:8021

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Metabolic_Enzyme_11_Gene_Sequence:
>1725 bp
ATGTGTCCCCGAGCCGCGCGGGCGCCCGCGACGCTACTCCTCGCCCTGGGCGCGGTGCTG
TGGCCTGCGGCTGGCGCCTGGGAGCTTACGATTTTGCACACCAACGACGTGCACAGCCGG
CTGGAGCAGACCAGCGAGGACTCCAGCAAGTGCGTCAACGCCAGCCGCTGCATGGGTGGC
GTGGCTCGGCTCTTCACCAAGGTTCAGCAGATCCGCCGCGCCGAACCCAACGTGCTGCTG
CTGGACGCCGGCGACCAGTACCAGGGCACTATCTGGTTCACCGTGTACAAGGGCGCCGAG
GTGGCGCACTTCATGAACGCCCTGCGCTACGATGCCATGGCACTGGGAAATCATGAATTT
GATAATGGTGTGGAAGGACTGATCGAGCCACTCCTCAAAGAGGCCAAATTTCCAATTCTG
AGTGCAAACATTAAAGCAAAGGGGCCACTAGCATCTCAAATATCAGGACTTTATTTGCCA
TATAAAGTTCTTCCTGTTGGTGATGAAGTTGTGGGAATCGTTGGATACACTTCCAAAGAA
ACCCCTTTTCTCTCAAATCCAGGGACAAATTTAGTGTTTGAAGATGAAATCACTGCATTA
CAACCTGAAGTAGATAAGTTAAAAACTCTAAATGTGAACAAAATTATTGCACTGGGACAT
TCGGGTTTTGAAATGGATAAACTCATCGCTCAGAAAGTGAGGGGTGTGGACGTCGTGGTG
GGAGGACACTCCAACACATTTCTTTACACAGGCAATCCACCTTCCAAAGAGGTGCCTGCT
GGGAAGTACCCATTCATAGTCACTTCTGATGATGGGCGGAAGGTTCCTGTAGTCCAGGCC
TATGCTTTTGGCAAATACCTAGGCTATCTGAAGATCGAGTTTGATGAAAGAGGAAACGTC
ATCTCTTCCCATGGAAATCCCATTCTTCTAAACAGCAGCATTCCTGAAGATCCAAGCATA
AAAGCAGACATTAACAAATGGAGGATAAAATTGGATAATTATTCTACCCAGGAATTAGGG
AAAACAATTGTCTATCTGGATGGCTCCTCTCAATCATGCCGCTTTAGAGAATGCAACATG
GGCAACCTGATTTGTGATGCAATGATTAACAACAACCTGAGACACACGGATGAAATGTTC
TGGAACCACGTATCCATGTGCATTTTAAATGGAGGTGGTATCCGGTCGCCCATTGATGAA
CGCAACAATGGCACAATTACCTGGGAGAACCTGGCTGCTGTATTGCCCTTTGGAGGCACA
TTTGACCTAGTCCAGTTAAAAGGTTCCACCCTGAAGAAGGCCTTTGAGCATAGCGTGCAC
CGCTACGGCCAGTCCACTGGAGAGTTCCTGCAGGTGGGCGGAATCCATGTGGTGTATGAT
CTTTCCCGAAAACCTGGAGACAGAGTAGTCAAATTAGATGTTCTTTGCACCAAGTGTCGA
GTGCCCAGTTATGACCCTCTCAAAATGGACGAGGTATATAAGGTGATCCTCCCAAACTTC
CTGGCCAATGGTGGAGATGGGTTCCAGATGATAAAAGATGAATTATTAAGACATGACTCT
GGTGACCAAGATATCAACGTGGTTTCTACATATATCTCCAAAATGAAAGTAATTTATCCA
GCAGTTGAAGGTCGGATCAAGTTTTCCACAGGAAGTCACTGCCATGGAAGCTTTTCTTTA
ATATTTCTTTCACTTTGGGCAGTGATCTTTGTTTTATACCAATAG

# Metabolic_Enzyme_11_GenBank_ID_Gene:
X55740

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_11_Locus:
6q14-q21

# Metabolic_Enzyme_11_SNPs:
Not Available

# Metabolic_Enzyme_11_General_References:
2129526; 8566797; 2173922; 9651114

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5233

# Metabolic_Enzyme_12_Name:
Cytosolic 5'-nucleotidase 1A

# Metabolic_Enzyme_12_Synonyms:
Cytosolic 5'-nucleotidase IA; cN1A; cN-IA; cN-I

# Metabolic_Enzyme_12_Gene_Name:
NT5C1A

# Metabolic_Enzyme_12_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
AMEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSR
ALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSED
VFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKV
REAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKA
HENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSW
GLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTA
PAKQAPSAQ

# Metabolic_Enzyme_12_Number_of_Residues:
368

# Metabolic_Enzyme_12_Molecular_Weight:
41021

# Metabolic_Enzyme_12_Theoretical_pI:
6.52

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_12_General_Function:
Not Available

# Metabolic_Enzyme_12_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia

# Metabolic_Enzyme_12_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_12_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_12_Signals:
None

# Metabolic_Enzyme_12_Transmembrane_Regions:
None

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_12_GenBank_ID_Protein:
12659324

# Metabolic_Enzyme_12_SwissProt_ID:
5NT1A_HUMAN (Q9BXI3)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
NT5C1A

# Metabolic_Enzyme_12_Geneatlas_id:
NT5C1A

# Metabolic_Enzyme_12_hgnc_id:
HGNC:17819

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_12_Gene_Sequence:
>1107 bp
ATGGAACCTGGGCAGCCCCGGGAGCCCCAGGAGCCCCGCGAGCCCGGGCCAGGAGCGGAG
ACCGCTGCGGCCCCGGTCTGGGAGGAAGCCAAGATTTTCTACGACAACCTCGCGCCCAAG
AAGAAACCCAAATCGCCCAAGCCTCAGAATGCAGTCACCATCGCTGTGTCCTCCCGAGCC
TTGTTTCGCATGGACGAGGAGCAGCAGATCTACACGGAGCAGGGCGTGGAGGAGTACGTG
CGCTACCAGCTGGAACATGAGAACGAACCCTTCAGTCCCGGGCCAGCCTTCCCTTTTGTG
AAGGCTCTGGAGGCCGTGAACAGGCGGCTGCGGGAGCTGTACCCTGATAGTGAGGACGTC
TTCGACATCGTCCTCATGACTAACAACCATGCTCAAGTGGGTGTCCGCCTCATCAACAGT
ATCAACCACTATGACCTGTTCATCGAGAGGTTCTGCATGACAGGTGGGAACAGCCCGATC
TGCTACCTCAAGGCCTATCACACCAACCTCTACTTGTCAGCCGATGCGGAAAAAGTGCGA
GAAGCCATTGATGAGGGGATCGCAGCTGCCACCATCTTCAGCCCCAGCAGGGATGTGGTT
GTGTCCCAGAGTCAGCTGCGCGTGGCCTTCGATGGGGACGCCGTGCTCTTCTCGGACGAG
TCGGAGCGCATCGTCAAGGCCCACGGGCTGGACCGATTCTTCGAGCATGAGAAGGCCCAC
GAGAACAAGCCTCTGGCTCAGGGCCCCTTAAAGGGCTTTCTGGAGGCACTGGGTAGGTTG
CAGAAGAAGTTCTACTCCAAAGGCCTGCGGCTGGAGTGCCCAATTCGTACCTACTTGGTG
ACAGCACGCAGTGCAGCCAGTTCCGGGGCCCGGGCTCTCAAGACCCTGCGCAGCTGGGGC
CTGGAGACAGATGAAGCCTTGTTCCTTGCTGGAGCGCCCAAGGGCCCTCTCCTTGAGAAG
ATCCGCCCACACATCTTCTTTGATGACCAGATGTTCCATGTGGCTGGGGCTCAGGAGATG
GGCACTGTGGCCGCCCATGTGCCTTATGGTGTGGCACAGACACCCCGGCGGACTGCACCT
GCAAAGCAGGCCCCATCTGCACAGTAG

# Metabolic_Enzyme_12_GenBank_ID_Gene:
AF331801

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_12_Locus:
1p34.3-p33

# Metabolic_Enzyme_12_SNPs:
rs4660340; rs784611; rs752667; rs1180272; rs1180271; rs784595; rs873917; rs1568146; rs1535031; rs3851911; rs17264901; rs784596; rs12566856; rs12406284; rs11807200; rs784597; rs784610; rs734497; rs3806428; rs784600; rs11809004; rs7553293; rs3806433; rs16826428; rs9660121; rs784599; rs3806429; rs784612; rs1533479; rs2871601; rs41264507; rs34479837; rs12035327; rs1180270; rs9439008; rs35574502; rs34779558; rs36025518; rs36123767; rs35625235; rs28507686; rs35550484; rs11206573; rs41264509; rs784598; rs34604809; rs1535030; rs5773668; rs1517187; rs12039176; rs28592113; rs784594; rs9438930; rs11306359; rs35355327; rs6684666; rs34908371; rs28667717; rs3806432; rs5773667; rs7416372; rs34045723; rs6672154; rs35002774; rs35256759; rs3806431; rs12042601; rs10465833; rs1062103; rs10839; rs10888919; rs10888929; rs11206525; rs1180275; rs1180277; rs12039225; rs12042356; rs12565281; rs13315; rs16826440; rs17501838; rs17560858; rs2281302; rs2746057; rs3207766; rs3806434; rs3916165; rs6663003; rs6703320; rs704769; rs736009; rs7419080; rs784601; rs784602; rs784613; rs784615; rs784616; rs784627; rs784629; rs784630; rs813052

# Metabolic_Enzyme_12_General_References:
11133996

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5236

# Metabolic_Enzyme_13_Name:
5'(3')-deoxyribonucleotidase, mitochondrial precursor

# Metabolic_Enzyme_13_Synonyms:
5',3'-nucleotidase, mitochondrial; Deoxy-5'-nucleotidase 2; dNT-2

# Metabolic_Enzyme_13_Gene_Name:
NT5M

# Metabolic_Enzyme_13_Protein_Sequence:
>5'3'deoxyribonucleotidase, mitochondrial precursor
MIRLGGWCARRLCSAAVPAGRRGAAGGLGLAGGRALRVLVDMDGVLADFEGGFLRKFRAR
FPDQPFIALEDRRGFWVSEQYGRLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMAS
LQNTDVFICTSPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDI
TGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRPC

# Metabolic_Enzyme_13_Number_of_Residues:
228

# Metabolic_Enzyme_13_Molecular_Weight:
25862

# Metabolic_Enzyme_13_Theoretical_pI:
8.12

# Metabolic_Enzyme_13_GO_Classification:
Not Available

# Metabolic_Enzyme_13_General_Function:
Not Available

# Metabolic_Enzyme_13_Specific_Function:
Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP

# Metabolic_Enzyme_13_Pathway:
Not Available

# Metabolic_Enzyme_13_Reaction:
Not Available

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_13_Signals:
1-15

# Metabolic_Enzyme_13_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_13_GenBank_ID_Protein:
9408106

# Metabolic_Enzyme_13_SwissProt_ID:
NT5M_HUMAN (Q9NPB1)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
NT5M

# Metabolic_Enzyme_13_Geneatlas_id:
NT5M

# Metabolic_Enzyme_13_hgnc_id:
HGNC:15769

# Metabolic_Enzyme_13_PDB_ID:
1Q92

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_13_Gene_Sequence:
>687 bp
ATGATCCGGCTGGGCGGCTGGTGTGCGCGGCGGCTCTGCAGCGCGGCGGTTCCCGCGGGG
CGGCGCGGGGCGGCGGGCGGGCTGGGCCTGGCGGGAGGCCGCGCCCTACGGGTGCTGGTG
GACATGGACGGCGTGCTGGCTGACTTCGAGGGCGGATTCCTCAGGAAGTTCCGCGCGCGC
TTTCCCGACCAGCCCTTCATCGCGCTGGAGGACCGGCGCGGCTTCTGGGTGTCGGAGCAG
TACGGCCGCCTGCGGCCAGGGCTGAGCGAGAAGGCCATCAGCATTTGGGAGTCAAAGAAT
TTCTTTTTTGAACTTGAGCCTCTGCCAGGGGCCGTGGAAGCTGTCAAGGAGATGGCCAGC
CTACAAAACACTGACGTCTTCATCTGCACAAGCCCCATCAAGATGTTCAAGTACTGTCCC
TATGAGAAGTATGCCTGGGTGGAGAAGTACTTTGGCCCTGACTTTCTGGAGCAGATTGTG
CTGACCAGAGACAAGACCGTGGTCTCTGCTGACCTTCTCATAGACGACCGGCCGGACATC
ACAGGGGCCGAGCCAACCCCCAGCTGGGAGCATGTCCTCTTCACCGCCTGCCACAACCAG
CACCTGCAGCTGCAGCCCCCCCGCCGCAGGCTGCACTCGTGGGCGGACGACTGGAAGGCC
ATTCTGGACAGCAAGCGGCCCTGCTGA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
AJ277557

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_13_Locus:
17p11.2

# Metabolic_Enzyme_13_SNPs:
rs2240876; rs758742; rs1860553; rs242243; rs6502579; rs7223473; rs11078384; rs7226068; rs10468464; rs12948296; rs1860552; rs9912109; rs9898622; rs7211968; rs17726703; rs9914692; rs3785502; rs11867932; rs3785504; rs17726673; rs11654778; rs16942153; rs17726858; rs11078382; rs3826302; rs2064060; rs6502580; rs7217503; rs9912172; rs3785506; rs9908168; rs11652902; rs9902505; rs4985707; rs6502576; rs6502578; rs16961564; rs7210344; rs16961516; rs242242; rs171394; rs12600778; rs9909111; rs7219752; rs6502577; rs12601631; rs11869054; rs17726924; rs9891799; rs11870836; rs11869507; rs11078383; rs4985706; rs7217162; rs9889738; rs9908338; rs7222555; rs9915883; rs7211243; rs9916133; rs9907857; rs9905836; rs11657817; rs9889298; rs7220829; rs9903425; rs9908360; rs9914424; rs9908124; rs11650700; rs11869079; rs7212369; rs9889367; rs7217114; rs9896977; rs9916676; rs16961561; rs12602026; rs9896970; rs9904396; rs9909850; rs10852849; rs11078385; rs6502575; rs242244; rs16961576; rs3203918; rs8082383; rs7212012; rs36114962; rs9889834; rs7226045; rs12602003; rs9894669; rs35712658; rs12941075; rs7210625; rs35320589; rs11655849; rs35470335; rs34668117; rs12943271; rs34446504; rs35945070; rs34219219; rs12951176; rs35554631; rs34408375; rs28825184; rs7218566; rs35917484; rs28880443; rs9904393; rs12601106; rs34579357; rs4985765; rs9907711; rs11343472; rs35579933; rs3087093; rs12951985; rs34993127; rs36088408; rs36091965; rs34100977; rs7220057; rs8080335; rs9901325; rs35720826; rs34886391; rs12949216; rs9898993; rs34121330; rs34513135; rs12936127; rs8067236; rs8081939; rs10617184; rs7211790; rs9914209; rs12951519; rs12603230; rs9913775; rs8068408; rs12452455; rs9901373; rs3063349; rs9913682; rs3785503; rs34156759; rs34776810; rs10574223; rs34836173; rs12951434; rs9709057; rs28813401; rs36146846; rs34709982; rs28616155; rs8082379; rs35267848; rs12951289; rs12948357; rs12950577; rs35861887; rs12948747; rs35096596; rs8080408; rs9898042; rs35930947; rs12948751; rs5741757; rs9889355; rs35575792; rs34018072; rs34407368; rs4985764; rs11395505; rs34676851; rs12951504; rs12950929; rs34025151; rs3837806; rs34247865; rs12946386; rs34209605; rs7219953; rs12951983; rs11400183; rs9912599; rs36056059; rs8071972; rs35039203; rs35326975; rs8071718; rs12946113; rs1009720; rs10852850; rs11078381; rs11078386; rs11871699; rs12450758; rs12451886; rs12452946; rs12602578; rs16961593; rs16961599; rs17648393; rs183596; rs190261; rs2041393; rs2058292; rs2191383; rs242246; rs242247; rs242249; rs242250; rs242251; rs624242; rs6502572; rs8067390; rs9892592; rs9899615; rs9905458; rs9909800; rs9914113

# Metabolic_Enzyme_13_General_References:
10899995; 12352955

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5337

# Metabolic_Enzyme_14_Name:
Uridine-cytidine kinase 1

# Metabolic_Enzyme_14_Synonyms:
UCK 1; Uridine monophosphokinase 1; Cytidine monophosphokinase 1

# Metabolic_Enzyme_14_Gene_Name:
UCK1

# Metabolic_Enzyme_14_Protein_Sequence:
>Uridinecytidine kinase 1
MASAGGEDCESPAPEADRPHQRPFLIGVSGGTASGKSTVCEKIMELLGQNEVEQRQRKVV
ILSQDRFYKVLTAEQKAKALKGQYNFDHPDAFDNDLMHRTLKNIVEGKTVEVPTYDFVTH
SRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDVRRGRDL
EQILTQYTTFVKPAFEEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDILNGDICKWHR
GGSNGRSYKRTFSEPGDHPGMLTSGKRSHLESSSRPH

# Metabolic_Enzyme_14_Number_of_Residues:
277

# Metabolic_Enzyme_14_Molecular_Weight:
31435

# Metabolic_Enzyme_14_Theoretical_pI:
7.33

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleoside kinase activity
Function:  uridine kinase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, 4-N-acetylcytidine, 4-N- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and 4-N-anisoylcytidine

# Metabolic_Enzyme_14_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_14_Reaction:
ATP + uridine = ADP + UMP

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00485:PRK

# Metabolic_Enzyme_14_Signals:
None

# Metabolic_Enzyme_14_Transmembrane_Regions:
None

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 2.7.1.48

# Metabolic_Enzyme_14_GenBank_ID_Protein:
13506765

# Metabolic_Enzyme_14_SwissProt_ID:
UCK1_HUMAN (Q9HA47)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
UCK1

# Metabolic_Enzyme_14_Geneatlas_id:
UCK1

# Metabolic_Enzyme_14_hgnc_id:
HGNC:14859

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Not Available

# Metabolic_Enzyme_14_Gene_Sequence:
>834 bp
ATGGCTTCGGCGGGAGGCGAAGACTGCGAGAGCCCCGCGCCGGAGGCCGACCGTCCGCAC
CAGCGGCCCTTCCTGATAGGGGTGAGCGGCGGCACTGCCAGCGGGAAGTCGACCGTGTGT
GAGAAGATCATGGAGTTGCTGGGACAGAACGAGGTGGAACAGCGGCAGCGGAAGGTGGTC
ATCCTGAGCCAGGACAGGTTCTACAAGGTCCTGACGGCAGAGCAGAAGGCCAAGGCCTTG
AAAGGACAGTACAATTTTGACCATCCAGATGCCTTTGATAATGATTTGATGCACAGGACT
CTGAAGAACATCGTGGAGGGCAAAACGGTGGAGGTGCCGACCTATGATTTTGTGACACAC
TCAAGGTTACCAGAGACCACGGTGGTCTACCCTGCGGACGTGGTTCTGTTTGAGGGCATC
TTGGTGTTCTACAGCCAGGAGATCCGGGACATGTTCCACCTGCGCCTCTTCGTGGACACC
GACTCCGACGTCAGGCTGTCTCGAAGAGTTCTCCGGGACGTGCGCCGAGGGAGGGACCTG
GAGCAGATTCTGACGCAGTACACCACCTTCGTGAAGCCGGCCTTCGAGGAGTTCTGCCTG
CCGACAAAGAAGTATGCCGATGTGATCATCCCGCGAGGAGTGGACAATATGGTTGCCATC
AACCTGATCGTGCAGCACATCCAGGACATTCTGAATGGTGACATCTGCAAATGGCACCGA
GGAGGGTCCAATGGGCGGAGCTACAAGCGGACCTTTTCTGAGCCAGGGGACCACCCTGGG
ATGCTGACCTCTGGCAAACGGTCACATTTGGAGTCCAGCAGCAGACCCCACTGA

# Metabolic_Enzyme_14_GenBank_ID_Gene:
AF237290

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_14_Locus:
9q34.13

# Metabolic_Enzyme_14_SNPs:
rs2296957; rs35991434; rs6597502; rs4740260; rs10793886; rs10793887; rs6597503; rs7859459; rs3808830; rs9785228; rs3904961; rs12682945; rs35345663; rs10609062; rs34523479; rs7869614; rs12377531; rs36042195; rs36102623; rs34811006; rs34625466; rs11440136; rs5900943; rs35542333; rs7862845; rs4292738; rs35582001; rs7040906; rs12684413; rs10257; rs1052561; rs10698; rs10793885; rs11005; rs11023; rs11243406; rs11243408; rs12003400; rs12115566; rs12551562; rs14188; rs1547768; rs17537644; rs2010635; rs2277152; rs2277153; rs2282010; rs2282011; rs2296956; rs3183977; rs34492185; rs34954751; rs3739495; rs3824395; rs3904960; rs4113141; rs4740165; rs4740257; rs4740259; rs4740263; rs7849433; rs7867616; rs7868519; rs7870715; rs946713

# Metabolic_Enzyme_14_General_References:
11306702

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5314

# Metabolic_Enzyme_15_Name:
Soluble calcium-activated nucleotidase 1

# Metabolic_Enzyme_15_Synonyms:
SCAN-1; Apyrase homolog; Putative NF-kappa-B-activating protein 107; Putative MAPK-activating protein PM09

# Metabolic_Enzyme_15_Gene_Name:
CANT1

# Metabolic_Enzyme_15_Protein_Sequence:
>Soluble calciumactivated nucleotidase 1
MPVQLSEHPEWNESMHSLRISVGGLPVLASMTKAADPRFRPRWKVILTFFVGAAILWLLC
SHRPAPGRPPTHNAHNWRLGQAPANWYNDTYPLSPPQRTPAGIRYRIAVIADLDTESRAQ
EENTWFSYLKKGYLTLSDSGDKVAVEWDKDHGVLESHLAEKGRGMELSDLIVFNGKLYSV
DDRTGVVYQIEGSKAVPWVILSDGDGTVEKGFKAEWLAVKDERLYVGGLGKEWTTTTGDV
VNENPEWVKVVGYKGSVDHENWVSNYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPR
RASQERYSEKDDERKGANLLLSASPDFGDIAVSHVGAVVPTHGFSSFKFIPNTDDQIIVA
LKSEEDSGRVASYIMAFTLDGRFLLPETKIGSVKYEGIEFI

# Metabolic_Enzyme_15_Number_of_Residues:
401

# Metabolic_Enzyme_15_Molecular_Weight:
44840

# Metabolic_Enzyme_15_Theoretical_pI:
5.98

# Metabolic_Enzyme_15_GO_Classification:
Not Available

# Metabolic_Enzyme_15_General_Function:
Not Available

# Metabolic_Enzyme_15_Specific_Function:
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP

# Metabolic_Enzyme_15_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_15_Reaction:
A nucleoside diphosphate + H2O = a nucleotide + phosphate

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF06079:Apyrase

# Metabolic_Enzyme_15_Signals:
None

# Metabolic_Enzyme_15_Transmembrane_Regions:
45-62

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 3.6.1.6

# Metabolic_Enzyme_15_GenBank_ID_Protein:
22218108

# Metabolic_Enzyme_15_SwissProt_ID:
CANT1_HUMAN (Q8WVQ1)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
CANT1

# Metabolic_Enzyme_15_Geneatlas_id:
CANT1

# Metabolic_Enzyme_15_hgnc_id:
HGNC:19721

# Metabolic_Enzyme_15_PDB_ID:
1S1D

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Intracytoplasmic membrane; single-pass type II membrane protein. Processed form:Secreted protein

# Metabolic_Enzyme_15_Gene_Sequence:
>1116 bp
ATGACCAAGGCCGCGGACCCCCGCTTCCGCCCCCGCTGGAAGGTGATCCTGACGTTCTTT
GTGGGTGCTGCCATCCTCTGGCTGCTCTGCTCCCACCGCCCGGCCCCCGGCAGGCCCCCC
ACCCACAATGCACACAACTGGAGGCTCGGCCAGGCGCCCGCCAACTGGTACAATGACACC
TACCCCCTGTCTCCCCCACAAAGGACACCGGCTGGGATTCGGTATCGAATCGCAGTTATC
GCAGACCTGGACACAGAGTCAAGGGCCCAAGAGGAAAACACCTGGTTCAGTTACCTGAAA
AAGGGCTACCTGACCCTGTCAGACAGTGGGGACAAGGTGGCCGTGGAATGGGACAAAGAC
CATGGGGTCCTGGAGTCCCACCTGGCGGAGAAGGGGAGAGGCATGGAGCTATCCGACCTG
ATTGTTTTCAATGGGAAACTCTACTCCGTGGATGACCGGACGGGGGTCGTCTACCAGATC
GAAGGCAGCAAAGCCGTGCCCTGGGTGATTCTGTCCGACGGCGACGGCACCGTGGAGAAA
GGCTTCAAGGCCGAATGGCTGGCAGTGAAGGACGAGCGTCTGTACGTGGGCGGCCTGGGC
AAGGAGTGGACGACCACTACGGGTGATGTGGTGAACGAGAACCCGGAGTGGGTGAAGGTG
GTGGGCTACAAGGGCAGCGTGGACCACGAGAACTGGGTGTCCAACTACAACGCCCTGCGG
GCTGCTGCCGGCATCCAGCCGCCAGGCTACCTCATCCATGAGTCTGCCTGCTGGAGTGAC
ACGCTGCAGCGCTGGTTCTTCCTGCCGCGCCGCGCCAGCCAGGAGCGCTACAGCGAGAAG
GACGACGAGCGCAAGGGCGCCAACCTGCTGCTGAGCGCCTCCCCTGACTTCGGCGACATC
GCTGTGAGCCACGTCGGGGCGGTGGTCCCCACTCACGGCTTCTCGTCCTTCAAGTTCATC
CCCAACACCGACGACCAGATCATTGTGGCCCTCAAATCCGAGGAGGACAGCGGCAGAGTC
GCCTCCTACATCATGGCCTTCACGCTGGACGGGCGCTTCCTGTTGCCGGAGACCAAGATC
GGAAGCGTGAAATACGAAGGCATCGAGTTCATTTAA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
AF328554

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_15_Locus:
17q25.3

# Metabolic_Enzyme_15_SNPs:
rs8077024; rs35290882; rs35324359; rs2377301; rs9916285; rs3744171; rs4789903; rs9896857; rs4789848; rs12450407; rs7214331; rs12450128; rs4789847; rs4861; rs11891; rs17739056; rs12452918; rs3744173; rs12949479; rs16971940; rs8079368; rs4789904; rs9904301; rs3744170; rs12452876; rs3744168; rs9915230; rs12452980; rs12451303; rs11546278; rs34082669; rs9903215; rs3803781; rs1127654; rs34461224; rs2377010; rs5017245; rs34435616; rs5017244; rs35308608; rs35755919; rs7219932; rs28627413; rs8078860; rs34996994; rs12936828; rs9899883; rs35356398; rs34938499; rs5017243; rs34572362; rs14791; rs4789849; rs34891215; rs2377009; rs34097366; rs35738150; rs5017242; rs3038740; rs35518955; rs9891726; rs3744169; rs12939358; rs12939350; rs12939399; rs4497730; rs6501274; rs9914188

# Metabolic_Enzyme_15_General_References:
12234496; 12761501; 12167635

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5440

# Metabolic_Enzyme_16_Name:
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase

# Metabolic_Enzyme_16_Synonyms:
Beta-galactoside alpha-2,6-sialyltransferase; Alpha 2,6-ST; Sialyltransferase 1; ST6Gal I; B-cell antigen CD75

# Metabolic_Enzyme_16_Gene_Name:
ST6GAL1

# Metabolic_Enzyme_16_Protein_Sequence:
>CMPNacetylneuraminatebetagalactosamidealpha2,6sialyltransferase
MIHTNLKKKFSCCVLVFLLFAVICVWKEKKKGSYYDSFKLQTKEFQVLKSLGKLAMGSDS
QSVSSSSTQDPHRGRQTLGSLRGLAKAKPEASFQVWNKDSSSKNLIPRLQKIWKNYLSMN
KYKVSYKGPGPGIKFSAEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGP
WGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTE
KRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYILKPQM
PWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFF
DSACTMGAYHPLLYEKNLVKHLNQGTDEDIYLLGKATLPGFRTIHC

# Metabolic_Enzyme_16_Number_of_Residues:
406

# Metabolic_Enzyme_16_Molecular_Weight:
46605

# Metabolic_Enzyme_16_Theoretical_pI:
9.35

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  sialyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  intrinsic to organelle membrane
Component:  intrinsic to Golgi membrane
Component:  integral to Golgi membrane

# Metabolic_Enzyme_16_General_Function:
Not Available

# Metabolic_Enzyme_16_Specific_Function:
Transfers sialic acid from the donor of substrate CMP- sialic acid to galactose containing acceptor substrates

# Metabolic_Enzyme_16_Pathway:
map00510  N-Glycan biosynthesis

# Metabolic_Enzyme_16_Reaction:
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF00777:Glyco_transf_29

# Metabolic_Enzyme_16_Signals:
1-27

# Metabolic_Enzyme_16_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 2.4.99.1

# Metabolic_Enzyme_16_GenBank_ID_Protein:
36462

# Metabolic_Enzyme_16_SwissProt_ID:
SIAT1_HUMAN (P15907)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
ST6GAL1

# Metabolic_Enzyme_16_Geneatlas_id:
ST6GAL1

# Metabolic_Enzyme_16_hgnc_id:
HGNC:10860

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Golgi apparatus; Golgi stack; Golgi stack membrane; single-pass type II membrane protein. Secreted protein. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid

# Metabolic_Enzyme_16_Gene_Sequence:
>1221 bp
ATGATTCACACCAACCTGAAGAAAAAGTTCAGCTGCTGCGTCCTGGTCTTTCTTCTGTTT
GCAGTCATCTGTGTGTGGAAGGAAAAGAAGAAAGGGAGTTACTATGATTCCTTTAAATTG
CAAACCAAGGAATTCCAGGTGTTAAAGAGTCTGGGGAAATTGGCCATGGGGTCTGATTCC
CAGTCTGTATCCTCAAGCAGCACCCAGGACCCCCACAGGGGCCGCCAGACCCTCGGCAGT
CTCAGAGGCCTAGCCAAGGCCAAACCAGAGGCCTCCTTCCAGGTGTGGAACAAGGACAGC
TCTTCCAAAAACCTTATCCCTAGGCTGCAAAAGATCTGGAAGAATTACCTAAGCATGAAC
AAGTACAAAGTGTCCTACAAGGGGCCAGGACCAGGCATCAAGTTCAGTGCAGAGGCCCTG
CGCTGCCACCTCCGGGACCATGTGAATGTATCCATGGTAGAGGTCACAGATTTTCCCTTC
AATACCTCTGAATGGGAGGGTTATCTGCCCAAGGAGAGCATTAGGACCAAGGCTGGGCCT
TGGGGCAGGTGTGCTGTTGTGTCGTCAGCGGGATCTCTGAAGTCCTCCCAACTAGGCAGA
GAAATCGATGATCATGACGCAGTCCTGAGGTTTAATGGGGCACCCACAGCCAACTTCCAA
CAAGATGTGGGCACAAAAACTACCATTCGCCTGATGAACTCTCAGTTGGTTACCACAGAG
AAGCGCTTCCTCAAAGACAGTTTGTACAATGAAGGAATCCTAATTGTATGGGACCCATCT
GTATACCACTCAGATATCCCAAAGTGGTACCAGAATCCGGATTATAATTTCTTTAACAAC
TACAAGACTTATCGTAAGCTGCACCCCAATCAGCCCTTTTACATCCTCAAGCCCCAGATG
CCTTGGGAGCTATGGGACATTCTTCAAGAAATCTCCCCAGAAGAGATTCAGCCAAACCCC
CCATCCTCTGGGATGCTTGGTATCATCATCATGATGACGCTGTGTGACCAGGTGGATATT
TATGAGTTCCTCCCATCCAAGCGCAAGACTGACGTGTGCTACTACTACCAGAAGTTCTTC
GATAGTGCCTGCACGATGGGTGCCTACCACCCGCTGCTCTATGAGAAGAATTTGGTGAAG
CATCTCAACCAGGGCACAGATGAGGACATCTACCTGCTTGGAAAAGCCACACTGCCTGGC
TTCCGGACCATTCACTGCTAA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
X17247

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_16_Locus:
3q27-q28

# Metabolic_Enzyme_16_SNPs:
rs7629263; rs16861573; rs1801380; rs967367; rs257108; rs7559; rs2268535; rs6444192; rs11711828; rs2268532; rs12495852; rs7621438; rs4234598; rs2268536; rs6783888; rs3892779; rs11923417; rs6444195; rs4686830; rs4686449; rs4686451; rs7617652; rs4686841; rs2268533; rs257109; rs13322149; rs3887925; rs3954170; rs3864110; rs6788832; rs10937275; rs9941987; rs759602; rs6444188; rs11715344; rs4686844; rs7619989; rs4012171; rs9869132; rs11719408; rs4686836; rs6780030; rs7643952; rs10937278; rs4686820; rs10804908; rs11711797; rs4012245; rs7619468; rs2284749; rs2889789; rs2268530; rs6444190; rs1042757; rs6444191; rs6791737; rs7617523; rs6444187; rs10937279; rs4420856; rs11927874; rs4012257; rs9851084; rs6766574; rs6444185; rs11712248; rs11717223; rs6802509; rs6444193; rs6800338; rs6780016; rs12636809; rs4396886; rs3733000; rs6444196; rs6444186; rs11707868; rs9869112; rs11707680; rs6764279; rs4012241; rs4686819; rs6808800; rs2377934; rs7626682; rs11707837; rs3864108; rs9852850; rs10513809; rs12493118; rs4686842; rs1989586; rs4012260; rs17775791; rs4686837; rs13322676; rs7632665; rs6792478; rs3864105; rs16861329; rs9847687; rs17774519; rs9852856; rs7622548; rs7633110; rs9858895; rs6771438; rs6809750; rs16861549; rs3888059; rs13325033; rs6799716; rs3954166; rs12495026; rs2239611; rs6775869; rs2077108; rs1042642; rs11720551; rs11719915; rs7637617; rs7621161; rs12054295; rs4686843; rs4686450; rs16861317; rs10212404; rs2006257; rs16848727; rs9875078; rs16861424; rs3872722; rs9799068; rs4686840; rs7643068; rs2019082; rs17774982; rs3864106; rs6444194; rs4686828; rs1989585; rs1811267; rs4686834; rs4012256; rs9863411; rs4686829; rs3868902; rs1981767; rs12629450; rs4686839; rs12490751; rs7652995; rs7637693; rs6764893; rs10513807; rs4261869; rs4686823; rs2268534; rs9860157; rs10513810; rs7634389; rs3954168; rs4686835; rs9875079; rs9875795; rs10937280; rs11717461; rs3868901; rs9828559; rs3821819; rs12633034; rs6764215; rs6768458; rs10804907; rs9844745; rs3936289; rs2284750; rs17718970; rs6804130; rs12495023; rs11710456; rs16861497; rs10513808; rs17776120; rs1811268; rs4686838; rs16861533; rs6792563; rs4686826; rs6781114; rs12632862; rs10212190; rs10513811; rs16861384; rs6783836; rs4626092; rs9851691; rs16861432; rs3882321; rs6776694; rs12152413; rs16861396; rs7611786; rs7633200; rs16861499; rs4686822; rs4686832; rs11719440; rs7635748; rs6807335; rs9716; rs769270; rs9876699; rs13070687; rs13100451; rs4686816; rs12054411; rs6768776; rs4686825; rs7632268; rs6784233; rs16861460; rs11929270; rs1009640; rs3954172; rs7622117; rs9290842; rs16861415; rs16861456; rs6806125; rs7622133; rs13317981; rs12497259; rs737509; rs9826667; rs16861325; rs6778436; rs7613731; rs9874817; rs3954167; rs4686815; rs9798820; rs6762406; rs16861421; rs13061952; rs6795614; rs6775942; rs7643789; rs4686817; rs9874262; rs3852060; rs7645517; rs3872721; rs9830384; rs12486343; rs9290841; rs9858925; rs12490407; rs7642349; rs5001409; rs9819341; rs13098740; rs4686818; rs12494144; rs16861316; rs6779920; rs6807292; rs17775211; rs6807433; rs6786498; rs11928027; rs9851238; rs6795811; rs16861471; rs3864107; rs3887361; rs4686833; rs2268531; rs6785668; rs6780488; rs16861388; rs13064443; rs11711183; rs4686821; rs6806052; rs3954169; rs10937277; rs2378123; rs17374323; rs3864109; rs4686824; rs16861319; rs6788604; rs16861339; rs17719366; rs3852061; rs3868043; rs4012243; rs4012250; rs2239612; rs6803985; rs4012247; rs7650237; rs4686847; rs4012246; rs2160472; rs6775413; rs12638323; rs1990676; rs12636803; rs4012249; rs9821439; rs6775701; rs12636876; rs2268526; rs9844388; rs6771150; rs6803087; rs6800443; rs7615919; rs7638437; rs9827876; rs257105; rs16861570; rs2111100; rs11929282; rs12490289; rs6803079; rs11915105; rs10433485; rs1558753; rs4012248; rs9855000; rs9843563; rs11929177; rs9847390; rs2377937; rs9847815; rs9814687; rs12054151; rs9847807; rs9825222; rs9860856; rs736341; rs16861562; rs9825352; rs2268527; rs9883086; rs7628418; rs4586798; rs12054054; rs1990677; rs257102; rs9827655; rs9828042; rs9682537; rs9682550; rs9869746; rs9825327; rs9843235; rs257104; rs16861566; rs11929248; rs2268528; rs11917671; rs4482660; rs9681892; rs9681214; rs9681891; rs257101; rs257103; rs6808590; rs9862574; rs9833709; rs9968113; rs11917979; rs257099; rs9814673; rs1468906; rs1468905; rs2041965; rs17719193; rs6775110; rs35193490; rs34794275; rs10212575; rs35403835; rs11380519; rs28533743; rs11367481; rs5855119; rs11922914; rs6799007; rs34935712; rs4012164; rs35363166; rs6777016; rs13060765; rs35102841; rs6786500; rs4487233; rs34450078; rs34644080; rs34815046; rs34644501; rs10716373; rs35859374; rs33995024; rs35001352; rs13318898; rs11425294; rs35452443; rs34847949; rs3872723; rs13082709; rs4012253; rs35176921; rs35923019; rs10654127; rs4012251; rs35291391; rs28607729; rs6444189; rs28599935; rs13064967; rs35762167; rs35589605; rs6777954; rs7430525; rs11293711; rs9847718; rs35410131; rs34465783; rs4686827; rs9820223; rs11457838; rs35133002; rs3887353; rs12494848; rs35550772; rs34058098; rs35123251; rs12152452; rs34442963; rs7643698; rs6148233; rs10620626; rs28637560; rs6802612; rs9825188; rs11554720; rs35135112; rs35852078; rs7626483; rs4263286; rs35409509; rs9814571; rs35653970; rs7647396; rs35704176; rs2377935; rs2041966; rs34520153; rs34406259; rs34630970; rs35011401; rs11394645; rs35012003; rs4012172; rs9875326; rs4686848; rs16861332; rs34290813; rs3931705; rs28679865; rs35456268; rs34926650; rs35421942; rs7612184; rs13058859; rs34297516; rs2889790; rs28578793; rs5855122; rs36077982; rs35186389; rs13064814; rs3891321; rs16861397; rs34394064; rs35595658; rs9864681; rs2014948; rs10591629; rs11287704; rs35913718; rs3890496; rs13315150; rs28685809; rs9849155; rs35936563; rs34443305; rs34000936; rs34616118; rs35673529; rs11457839; rs3755791; rs35316168; rs35564667; rs7623257; rs13315159; rs11280596; rs4012167; rs3834202; rs35309256; rs28412033; rs35719616; rs11363479; rs3902002; rs12639573; rs3182249; rs10569931; rs34830846; rs11717415; rs11301684; rs11387724; rs28537473; rs34902580; rs34180584; rs35903308; rs34329865; rs34474251; rs34027009; rs35693392; rs35357452; rs36055194; rs35376994; rs34605510; rs28564410; rs17719057; rs34534870; rs11554721; rs7622579; rs35534639; rs35461422; rs13064301; rs35954975; rs10937276; rs9824989; rs13081306; rs13071014; rs9860975; rs36027751; rs34963554; rs34636425; rs34382694; rs9829951; rs33963589; rs35832957; rs7622288; rs10433484; rs34802087; rs6802782; rs34129058; rs5855117; rs9818640; rs17374212; rs3890497; rs34837598; rs13088725; rs11332772; rs35911415; rs35471645; rs6786531; rs28712718; rs4012242; rs10691478; rs28528319; rs1042643; rs5855121; rs34901926; rs13097481; rs35397933; rs10562351; rs9868507; rs35135432; rs35926503; rs36103477; rs13082825; rs10622223; rs36067744; rs11924808; rs35590424; rs1981766; rs3902001; rs13082586; rs6809209; rs12019227; rs35079778; rs35766175; rs28867816; rs11554722; rs36234165; rs34727437; rs10623575; rs35313647; rs34577462; rs11716393; rs13071610; rs34631478; rs5855118; rs11360884; rs10609370; rs13060992; rs33933543; rs35131547; rs28501467; rs28674898; rs34647403; rs34585461; rs10665136; rs34426601; rs35176351; rs36011306; rs36048124; rs13086938; rs12152453; rs35936624; rs3887352; rs34987823; rs10619915; rs4686831; rs34602629; rs5855120; rs34266471; rs35558842; rs34190794; rs28599807; rs13060784; rs34503745; rs35089736; rs34244342; rs34043185; rs4328793; rs3872724; rs34302492; rs13080971; rs7637730; rs34622098; rs12634192; rs16861556; rs28750501; rs10620822; rs34522624; rs35896179; rs3055154; rs34389560; rs3774263; rs28460831; rs11330261; rs35112994; rs9877931; rs34414989; rs6770178; rs257106; rs4629326; rs34074750; rs2284751; rs28793680; rs34347356; rs7613498; rs10718824; rs35088576; rs4479590; rs35068419; rs3831821; rs9839737; rs13087260; rs12634172; rs6775512; rs34646902; rs11360011; rs13087263; rs9871278; rs9881904; rs10710055; rs34578573; rs4686845; rs6802264; rs2377936; rs10545094; rs34626272; rs28797570; rs3055152; rs35882828; rs35875254; rs257100; rs3836476; rs35589599; rs257107; rs13100651; rs35592281; rs2268529; rs34094480; rs4686846; rs35252394; rs28366036; rs36052434; rs28366037; rs28366038; rs13059833; rs35974903; rs34101010; rs34495955; rs6809378; rs35935172; rs1468907; rs11915784; rs12630598; rs12632422; rs13062752; rs13095782; rs1558754; rs2541251; rs34555686; rs35166820; rs35376159; rs35508867; rs3901490; rs4496468; rs4686453; rs4686814; rs4686849; rs6797083; rs7356053; rs7611749; rs7634009; rs7634671; rs7650956; rs9810189; rs9813056; rs9884076

# Metabolic_Enzyme_16_General_References:
2408023; 2373995; 1730763; 2803295

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5237

# Metabolic_Enzyme_17_Name:
Cytosolic purine 5'-nucleotidase

# Metabolic_Enzyme_17_Synonyms:
5'-nucleotidase cytosolic II

# Metabolic_Enzyme_17_Gene_Name:
NT5C2

# Metabolic_Enzyme_17_Protein_Sequence:
>Cytosolic purine 5'nucleotidase
MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVY
KSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLV
CAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTS
CETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMK
EVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGT
VLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKS
KKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQ
RRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAA
HVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLA
PQEITHCHDEDDDEEEEEEEE

# Metabolic_Enzyme_17_Number_of_Residues:
561

# Metabolic_Enzyme_17_Molecular_Weight:
64970

# Metabolic_Enzyme_17_Theoretical_pI:
6.05

# Metabolic_Enzyme_17_GO_Classification:
Not Available

# Metabolic_Enzyme_17_General_Function:
Not Available

# Metabolic_Enzyme_17_Specific_Function:
May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides

# Metabolic_Enzyme_17_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_17_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF05761:5_nucleotid

# Metabolic_Enzyme_17_Signals:
None

# Metabolic_Enzyme_17_Transmembrane_Regions:
None

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_17_GenBank_ID_Protein:
633071

# Metabolic_Enzyme_17_SwissProt_ID:
5NTC_HUMAN (P49902)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
NT5C2

# Metabolic_Enzyme_17_Geneatlas_id:
NT5C2

# Metabolic_Enzyme_17_hgnc_id:
HGNC:8022

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_17_Gene_Sequence:
>1686 bp
ATGTCGACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGAT
AAGCATGCCCTGAAAAAGTATCGTCGAGAAGCCTATCATCGGGTGTTTGTGAACCGAAGT
TTAGCAATGGAAAAGATAAAGTGTTTTGGTTTTGATATGGATTATACCCTTGCTGTGTAC
AAGTCCCCAGAGTATGAGTCCCTTGGTTTTGAGCTTACTGTGGAGAGATTAGTTTCTATT
GGCTATCCCCAGGAGTTGCTCAGCTTTGCTTATGATTCTACATTCCCTACCAGGGGACTT
GTCTTTGACACACTGTATGGAAATCTTTTGAAAGTCGATGCCTATGGAAACCTCTTGGTC
TGTGCACATGGATTTAACTTTATAAGGGGACCAGAAACTAGAGAACAGTATCCAAATAAA
TTTATCCAGCGAGATGATACTGAAAGATTTTACATTCTGAACACACTATTCAACCTACCA
GAGACCTACCTGTTGGCCTGCCTAGTAGATTTTTTTACTAATTGTCCCAGATATACCAGT
TGTGAAACAGGATTTAAAGATGGGGACCTCTTCATGTCCTACCGGAGTATGTTCCAGGAT
GTAAGAGATGCTGTTGACTGGGTTCATTACAAGGGCTCCCTTAAGGAAAAGACAGTTGAA
AATCTTGAGAAGTATGTAGTCAAAGATGGAAAACTGCCTTTGCTTCTGAGCCGGATGAAG
GAAGTAGGGAAAGTATTTCTTGCTACCAACAGTGACTATAAATATACAGATAAAATTATG
ACTTACCTGTTTGACTTCCCACATGGCCCCAAGCCTGGGAGCTCCCATCGACCATGGCAG
TCCTACTTTGACTTGATCTTGGTGGATGCACGGAAACCACTCTTTTTTGGAGAAGGCACA
GTACTGCGTCAGGTGGATACTAAAACTGGCAAGCTGAAAATTGGTACCTACACAGGGCCC
CTACAGCATGGTATCGTCTACTCAGGAGGTTCTTCTGATACGATCTGTGACCTGTTGGGA
GCCAAGGGAAAAGACATTTTGTATATTGGAGATCACATTTTTGGGGACATTTTAAAATCA
AAGAAACGGCAAGGGTGGCGAACTTTTTTGGTGATTCCTGAACTCGCACAGGAGCTACAT
GTCTGGACTGACAAGAGTTCACTTTTCGAAGAACTTCAGAGCTTGGATATTTTCTTGGCT
GAACTCTACAAGCATCTTGACAGCAGTAGCAATGAGCGTCCAGACATCAGTTCCATCCAG
AGACGTATTAAGAAAGTAACTCATGACATGGACATGTGCTATGGGATGATGGGAAGCCTG
TTTCGCAGTGGCTCCCGGCAGACCCTTTTTGCCAGTCAAGTGATGCGTTATGCTGACCTC
TATGCAGCATCTTTCATCAACCTGCTGTATTACCCTTTCAGCTACCTCTTCAGGGCTGCC
CATGTCTTGATGCCTCATGAATCAACGGTGGAGCACACACACGTAGATATCAATGAGATG
GAGTCTCCTCTTGCCACCCGGAACCGCACATCAGTGGATTTCAAAGACACTGACTACAAG
CGGCACCAGCTGACACGGTCAATTAGTGAGATTAAACCTCCCAACCTCTTCCCACTGGCC
CCCCAGGAAATTACACACTGCCATGACGAAGATGATGATGAAGAGGAGGAGGAGGAGGAA
GAATAA

# Metabolic_Enzyme_17_GenBank_ID_Gene:
D38524

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_17_Locus:
10q24.32-q24.33

# Metabolic_Enzyme_17_SNPs:
rs12262171; rs3740387; rs12253627; rs10786736; rs8139; rs7917650; rs10786741; rs7920251; rs10430665; rs7916854; rs12573199; rs11191598; rs1163238; rs12573200; rs10883843; rs7092407; rs12573221; rs4917997; rs11191593; rs11191596; rs10786744; rs1163236; rs10883842; rs10786742; rs10786743; rs7075552; rs7077097; rs2863728; rs3758543; rs7077291; rs10748838; rs3087681; rs12240508; rs732998; rs10883830; rs7899084; rs2274340; rs2182348; rs2066322; rs7908960; rs7912517; rs7067970; rs3740386; rs7896547; rs11191554; rs1163249; rs2281877; rs2863727; rs3781281; rs2274341; rs2148198; rs7897663; rs3781282; rs10883832; rs1926029; rs1935323; rs1926030; rs746293; rs6584539; rs2066323; rs9919482; rs3740385; rs12773916; rs12414232; rs10786737; rs12413046; rs12412038; rs2274339; rs11598702; rs1541213; rs11191580; rs11191553; rs10509765; rs10509766; rs3977751; rs12220375; rs4917996; rs7896433; rs6584540; rs1926037; rs3736922; rs11191577; rs2148197; rs11191561; rs7080935; rs11191555; rs10883833; rs12219304; rs1926036; rs7913920; rs10883834; rs11191558; rs11191582; rs11191589; rs10883831; rs12220743; rs10786738; rs11191560; rs10748837; rs11191578; rs3781280; rs7896519; rs12217501; rs11191573; rs7067741; rs6584541; rs7067663; rs2148200; rs10883840; rs11191583; rs12415199; rs9919485; rs11191557; rs17094683; rs7895154; rs12355120; rs2153774; rs10786739; rs7915816; rs7081075; rs1807298; rs3861984; rs11191572; rs12571568; rs12416331; rs11191586; rs10883839; rs12766205; rs1163239; rs10883837; rs11191584; rs1163247; rs17115452; rs11191556; rs7909022; rs12775302; rs9633712; rs11191581; rs11191576; rs10883836; rs11191549; rs7095304; rs10883845; rs11191550; rs11191548; rs11191602; rs10748839; rs1141101; rs1055812; rs1141100; rs1141098; rs1141099; rs34351688; rs34394526; rs34058246; rs11191594; rs35224704; rs34747231; rs12774207; rs11191595; rs34699185; rs11280184; rs1163237; rs7073259; rs34064597; rs11191601; rs35525740; rs35291480; rs12264098; rs35978588; rs12241986; rs7091462; rs12774182; rs34756486; rs35695488; rs12252236; rs3834416; rs11191600; rs34136949; rs7080242; rs12763243; rs34003851; rs11191585; rs11191551; rs36111455; rs34966121; rs35464534; rs35541240; rs11191571; rs35913488; rs34223002; rs11440429; rs41287482; rs35653865; rs34963818; rs11191559; rs11191568; rs35436872; rs17795366; rs1163246; rs34060908; rs34963563; rs34915846; rs12780509; rs2153773; rs34211645; rs3736924; rs34758128; rs36059537; rs35302704; rs12255989; rs34104646; rs11191574; rs11191564; rs35745742; rs34644789; rs5787481; rs34863357; rs11191590; rs12774840; rs2148196; rs12763944; rs3215816; rs34207290; rs35752695; rs34445719; rs28419708; rs4421684; rs28516969; rs12265498; rs12767422; rs12772228; rs34908445; rs11191570; rs17115449; rs35195396; rs12243923; rs10883835; rs12779263; rs11302933; rs7091173; rs11375439; rs7071103; rs35146429; rs35338839; rs34268365; rs34130454; rs35898850; rs3861983; rs28404041; rs35621207; rs3736923; rs5787482; rs7075048; rs34307431; rs35348020; rs34349473; rs1773930; rs11191566; rs34870452; rs35078544; rs35123178; rs12265545; rs1163241; rs3949893; rs7904067; rs12775841; rs35821867; rs12775904; rs7915032; rs5028036; rs35254502; rs1163248; rs35365027; rs34876862; rs11191565; rs12772280; rs10709724; rs35085852; rs35351555; rs12774513; rs10710371; rs11296588; rs12243903; rs28605898; rs34241930; rs34549427; rs11451961; rs34403968; rs12761657; rs34397864; rs3062737; rs36092020; rs35109679; rs34011916; rs34435560; rs11191562; rs4917383; rs34067380; rs34202831; rs11191563; rs2148199; rs34133379; rs35763505; rs12414385; rs1163240; rs12262258; rs11191588; rs34664715; rs12414374; rs35133717; rs3837340; rs10614009; rs2153772; rs11191587; rs11403586; rs11191575; rs1060240; rs34588165; rs11191552; rs41317254; rs1163245; rs1064099; rs12268552; rs34833988; rs11191603; rs12253716; rs12412924; rs3841710; rs34551510; rs12246784; rs12781668; rs1064098; rs10458729; rs10786740; rs10786745; rs10883829; rs10883841; rs11191547; rs1163235; rs12261294; rs12571345; rs12785223; rs17115427; rs4307650; rs4917382; rs4917995; rs7074395; rs7092200; rs726010; rs763914; rs7921996; rs943035

# Metabolic_Enzyme_17_General_References:
7999131

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
6053

# Metabolic_Enzyme_18_Name:
Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl- galactosaminide alpha-2,6-sialyltransferase

# Metabolic_Enzyme_18_Synonyms:
NeuAc- alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase; ST6GalNAc IV; Sialyltransferase 7D; Sialyltransferase 3C

# Metabolic_Enzyme_18_Gene_Name:
ST6GALNAC4

# Metabolic_Enzyme_18_Protein_Sequence:
>AlphaNacetylneuraminyl2,3betagalactosyl1,3Nacetyl galactosaminide alpha2,6sialyltransferase
MKAPGRLVLIILCSVVFSAVYILLCCWAGLPLCLATCLDHHFPTGSRPTVPGPLHFSGYS
SVPDGKPLVREPCRSCAVVSSSGQMLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRST
LRVVSHTSVPLLLRNYSHYFQKARDTLYMVWGQGRHMDRVLGGRTYRTLLQLTRMYPGLQ
VYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYGMVSDSYCR
EKSHPSVPYHYFEKGRLDECQMYLAHEQAPRSAHRFITEKAVFSRWAKKRPIVFAHPSWR
TE

# Metabolic_Enzyme_18_Number_of_Residues:
302

# Metabolic_Enzyme_18_Molecular_Weight:
34201

# Metabolic_Enzyme_18_Theoretical_pI:
8.65

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  sialyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  intrinsic to organelle membrane
Component:  intrinsic to Golgi membrane
Component:  integral to Golgi membrane

# Metabolic_Enzyme_18_General_Function:
Not Available

# Metabolic_Enzyme_18_Specific_Function:
Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids

# Metabolic_Enzyme_18_Pathway:
map00604  Ganglioside biosynthesis

# Metabolic_Enzyme_18_Reaction:
CMP-N-acetylneuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF00777:Glyco_transf_29

# Metabolic_Enzyme_18_Signals:
1-35

# Metabolic_Enzyme_18_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 2.4.99.7

# Metabolic_Enzyme_18_GenBank_ID_Protein:
9998769

# Metabolic_Enzyme_18_SwissProt_ID:
SIA7D_HUMAN (Q9H4F1)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
ST6GALNAC4

# Metabolic_Enzyme_18_Geneatlas_id:
ST6GALNAC4

# Metabolic_Enzyme_18_hgnc_id:
HGNC:17846

# Metabolic_Enzyme_18_PDB_ID:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_18_Gene_Sequence:
>909 bp
ATGAAGGCTCCGGGTCGGCTCGTGCTCATCATCCTGTGCTCCGTGGTCTTCTCTGCCGTC
TACATCCTCCTGTGCTGCTGGGCCGGCCTGCCCCTCTGCCTGGCCACCTGCCTGGACCAC
CACTTCCCCACAGGCTCCAGGCCCACTGTGCCGGGACCCCTGCACTTCAGTGGATATAGC
AGTGTGCCAGATGGGAAGCCGCTGGTCCGCGAGCCCTGCCGCAGCTGTGCCGTGGTGTCC
AGCTCCGGCCAAATGCTGGGCTCAGGCCTGGGTGCTGAGATCGACAGTGCCGAGTGCGTG
TTCCGCATGAACCAGGCGCCCACCGTGGGCTTTGAGGCGGATGTGGGCCAGCGCACGACC
CTGCGTGTCGTCTCACACACAAGCGTGCCGCTGCTGCTGCGCAACTATTCACACTACTTC
CAGAAGGCCCGAGACACGCTCTACATGGTGTGGGGCCAGGGCAGGCACATGGACCGGGTG
CTCGGCGGCCGCACCTACCGCACGCTGCTGCAGCTCACCAGGATGTACCCCGGCCTGCAG
GTGTACACCTTCACGGAGCGCATGATGGCCTACTGCGACCAGATCTTCCAGGACGAGACG
GGCAAGAACCGGAGACAGTCGGGCTCCTTCCTCAGCACCGGCTGGTTCACCATGATCCTC
GCGCTGGAGCTGTGTGAGGAGATCGTGGTCTATGGGATGGTCAGCGACAGCTACTGCAGG
GAGAAGAGCCACCCCTCAGTGCCTTACCACTACTTTGAGAAGGGCCGGCTAGATGAGTGT
CAGATGTACCTGGCACACGAGCAAGCGCCCCGAAGCGCCCACCGCTTCATCACTGAGAAG
GCGGTCTTCTCCCGCTGGGCCAAGAAGAGGCCCATCGTGTTCGCCCATCCGTCCTGGAGG
ACTGAGTAG

# Metabolic_Enzyme_18_GenBank_ID_Gene:
AJ271734

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_18_Locus:
9q34

# Metabolic_Enzyme_18_SNPs:
rs13510; rs2296703; rs35701259; rs1127024; rs3818509; rs2274423; rs1043012; rs1043026; rs1062665; rs7468519; rs7026378; rs3780668; rs10760512; rs10819318; rs10819319; rs10739699; rs10739700; rs10760511; rs10760513; rs10760510; rs7874664; rs10819317; rs2094333; rs16930160; rs7875220; rs34381924; rs1043018; rs34390490; rs34201486; rs7856453; rs35168848; rs11794334; rs11788494; rs12552745; rs35789116; rs34377256; rs13293839; rs13293855; rs13294287; rs35079486; rs41312218; rs11409543; rs2182619; rs4388550; rs35502853; rs34124228; rs12004868; rs1571142; rs16930158; rs2417061; rs36045253; rs3758328; rs3758330; rs4419909; rs4836591; rs4837204; rs4837205

# Metabolic_Enzyme_18_General_References:
11062056; 10369878

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5439

# Metabolic_Enzyme_19_Name:
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3- sialyltransferase

# Metabolic_Enzyme_19_Synonyms:
N-acetyllactosaminide alpha-2,3- sialyltransferase; Gal beta-1,3(4GlcNAc alpha-2,3 sialyltransferase; ST3N; ST3GalIII; Sialyltransferase 6

# Metabolic_Enzyme_19_Gene_Name:
ST3GAL3

# Metabolic_Enzyme_19_Protein_Sequence:
>CMPNacetylneuraminatebeta1,4galactoside alpha2,3 sialyltransferase
MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSNSVVLSFDSAGQTLGSEYDRL
GFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARI
REFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDD
YDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLK
YIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIP
TLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLR
KLVKARVITDLSSGI

# Metabolic_Enzyme_19_Number_of_Residues:
375

# Metabolic_Enzyme_19_Molecular_Weight:
42171

# Metabolic_Enzyme_19_Theoretical_pI:
9.31

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  sialyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  intrinsic to organelle membrane
Component:  intrinsic to Golgi membrane
Component:  integral to Golgi membrane

# Metabolic_Enzyme_19_General_Function:
Not Available

# Metabolic_Enzyme_19_Specific_Function:
Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta- 1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- or NeuAc-alpha- 2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3- GalNAc

# Metabolic_Enzyme_19_Pathway:
map00533  Keratan sulfate biosynthesis;
 map00601  Blood group glycolipid biosynthesis-lactoseries

# Metabolic_Enzyme_19_Reaction:
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF00777:Glyco_transf_29

# Metabolic_Enzyme_19_Signals:
1-21

# Metabolic_Enzyme_19_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 2.4.99.6

# Metabolic_Enzyme_19_GenBank_ID_Protein:
388015

# Metabolic_Enzyme_19_SwissProt_ID:
SIAT6_HUMAN (Q11203)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
ST3GAL3

# Metabolic_Enzyme_19_Geneatlas_id:
ST3GAL3

# Metabolic_Enzyme_19_hgnc_id:
HGNC:10866

# Metabolic_Enzyme_19_PDB_ID:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Golgi apparatus; Golgi stack; Golgi stack membrane; single-pass type II membrane protein. Secreted protein. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid

# Metabolic_Enzyme_19_Gene_Sequence:
>1128 bp
ATGGGACTCTTGGTATTTGTGCGCAATCTGCTGCTAGCCCTCTGCCTCTTTCTGGTACTG
GGATTTTTGTATTATTCTGCGTGGAAGCTACACTTACTCCAGTGGGAGGAGGACTCCAAT
TCAGTGGTTCTTTCCTTTGACTCCGCTGGACAAACACTAGGCTCAGAGTATGATCGGTTG
GGCTTCCTCCTGAATCTGGACTCTAAACTGCCTGCTGAATTAGCCACCAAGTACGCAAAC
TTTTCAGAGGGAGCTTGCAAGCCTGGCTATGCTTCAGCCTTGATGACGGCCATCTTCCCC
CGGTTCTCCAAGCCAGCACCCATGTTCCTGGATGACTCCTTTCGCAAGTGGGCTAGAATC
CGGGAGTTCGTGCCGCCTTTTGGGATCAAAGGTCAAGACAATCTGATCAAAGCCATCTTG
TCAGTCACCAAAGAGTACCGCCTGACCCCTGCCTTGGACAGCCTCCGCTGCCGCCGCTGC
ATCATCGTGGGCAATGGAGGCGTTCTTGCCAACAAGTCTCTGGGGTCACGAATTGACGAC
TATGACATTGTGGTGAGACTGAATTCAGCACCAGTGAAAGGCTTTGAGAAGGACGTGGGC
AGCAAAACGACACTGCGCATCACCTACCCCGAGGGCGCCATGCAGCGGCCTGAGCAGTAC
GAGCGCGATTCTCTCTTTGTCCTCGCCGGCTTCAAGTGGCAGGACTTTAAGTGGTTGAAA
TACATCGTCTACAAGGAGAGAGTGAGTGCATCGGATGGCTTCTGGAAATCTGTGGCCACT
CGAGTGCCCAAGGAGCCCCCTGAGATTCGAATCCTCAACCCATATTTCATCCAGGAGGCC
GCCTTCACCCTCATTGGCCTGCCCTTCAACAATGGCCTCATGGGCCGGGGGAACATCCCT
ACCCTTGGCAGTGTGGCAGTGACCATGGCACTACACGGCTGTGACGAGGTGGCAGTCGCA
GGATTTGGCTATGACATGAGCACACCCAACGCACCCCTGCACTACTATGAGACCGTTCGC
ATGGCAGCCATCAAAGAGTCCTGGACGCACAATATCCAGCGAGAGAAAGAGTTTCTGCGG
AAGCTGGTGAAAGCTCGCGTCATCACTGATCTAAGCAGTGGCATCTGA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
L23768

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_19_Locus:
1p34.1

# Metabolic_Enzyme_19_SNPs:
rs37458; rs2485990; rs304300; rs304303; rs6429637; rs6801; rs6429635; rs11210906; rs11210905; rs4660260; rs7536221; rs7539483; rs11210904; rs12410155; rs7528454; rs11210903; rs12561948; rs1859726; rs11210909; rs7548155; rs6693799; rs10890273; rs11210907; rs3862228; rs12139239; rs6684338; rs17531412; rs16831095; rs10890274; rs16831102; rs12140156; rs4660259; rs16831096; rs12118210; rs11210910; rs4660258; rs6673970; rs11577037; rs12119146; rs4660743; rs7528907; rs7538463; rs11210908; rs12118274; rs11810109; rs803678; rs803675; rs803680; rs3011228; rs976313; rs783302; rs1875653; rs1013793; rs37453; rs917294; rs803679; rs1502907; rs3094954; rs37460; rs2906466; rs2428851; rs3011227; rs37457; rs803683; rs2428964; rs1636876; rs1472661; rs2108202; rs3011222; rs2352990; rs12127226; rs3011224; rs37456; rs3791041; rs7515003; rs11210936; rs713191; rs3791089; rs3011220; rs1029632; rs2428960; rs2428963; rs4660749; rs810680; rs3791068; rs246777; rs3791069; rs6692033; rs7520053; rs3791040; rs11210916; rs6665014; rs3791058; rs2906465; rs3791049; rs6664485; rs9326136; rs2245439; rs803682; rs6656457; rs2906461; rs2527776; rs3791057; rs3011223; rs6429638; rs7516647; rs2428853; rs10890279; rs3791062; rs3791085; rs11210935; rs556667; rs11210924; rs3828139; rs7536198; rs3791059; rs11577684; rs10890276; rs3011221; rs246778; rs3791051; rs6701645; rs2248305; rs2486012; rs783304; rs4660261; rs976312; rs4031031; rs7546818; rs783301; rs3791046; rs972444; rs3124746; rs7551272; rs11210928; rs12072172; rs11210917; rs3791042; rs3791083; rs12024345; rs12128485; rs1012125; rs7542434; rs3791064; rs16831390; rs17474535; rs11590088; rs1354261; rs10890282; rs2906468; rs6676424; rs3011225; rs10890283; rs3952787; rs12131981; rs3791112; rs946237; rs3791087; rs7549701; rs11210926; rs3791078; rs16831192; rs3791092; rs2040950; rs3791074; rs803676; rs11210934; rs6429639; rs37463; rs11210919; rs803681; rs4314918; rs2485996; rs6665149; rs3791048; rs2906458; rs16831424; rs12569354; rs16831180; rs12128547; rs3791043; rs3791081; rs11210927; rs7553818; rs641356; rs812490; rs12133508; rs3011216; rs3791111; rs12741189; rs3120802; rs783303; rs37464; rs16831120; rs37452; rs2486011; rs972443; rs2906457; rs975761; rs7551644; rs6680928; rs1859725; rs11210911; rs3791073; rs6429640; rs3011226; rs2906467; rs12569336; rs6691988; rs6692652; rs4660745; rs3120803; rs6674176; rs2367725; rs12125838; rs12741964; rs12037700; rs3011217; rs3011219; rs7529895; rs11210914; rs11579637; rs6669157; rs11210930; rs16831389; rs10890281; rs3791090; rs3791067; rs3791063; rs1766966; rs3791101; rs2428854; rs3791047; rs2788371; rs6670344; rs3011229; rs37462; rs11800217; rs6659334; rs9662379; rs10157382; rs9726489; rs2108420; rs12122504; rs12144781; rs3791050; rs11580676; rs11210925; rs11210915; rs4660262; rs37470; rs12122867; rs12121968; rs11578313; rs37459; rs3791053; rs12354267; rs6688144; rs11210931; rs11580407; rs3791110; rs16831373; rs12126352; rs12137475; rs16831381; rs12062824; rs7543520; rs37468; rs4660753; rs3011231; rs12566767; rs2367805; rs11210918; rs7544428; rs11210920; rs16831205; rs12401813; rs2158954; rs7538822; rs12403488; rs16831354; rs12076860; rs2485991; rs2527777; rs11210932; rs2108419; rs3828140; rs2906455; rs10890278; rs3891573; rs3791104; rs12126193; rs3791045; rs11581514; rs37471; rs16831403; rs12116642; rs11210912; rs12066109; rs3791097; rs12120287; rs11587427; rs16831302; rs917293; rs16831407; rs2367804; rs3791108; rs7546040; rs7553659; rs3888199; rs10890280; rs42962; rs12119149; rs37469; rs16831384; rs2428852; rs6672795; rs803677; rs2158955; rs11810146; rs764767; rs12142533; rs11210922; rs7549094; rs10890284; rs2906462; rs541487; rs2041069; rs7552219; rs2485997; rs2428962; rs3791102; rs11210913; rs6700256; rs246776; rs3791055; rs2906470; rs1990195; rs12123718; rs12567510; rs11586049; rs17533707; rs7531165; rs12567668; rs6678767; rs11590279; rs246773; rs3791056; rs12127702; rs12760274; rs3791106; rs9787240; rs16831347; rs4660750; rs11587515; rs11584382; rs12564694; rs3791076; rs2906463; rs12092342; rs16831299; rs10890277; rs6686238; rs3764833; rs16831166; rs6668616; rs2428961; rs34402506; rs12140044; rs12096419; rs813391; rs36044239; rs186238; rs35008229; rs35936982; rs4660742; rs12736515; rs11275853; rs34880307; rs6659622; rs810696; rs11318191; rs12752142; rs667906; rs12044880; rs10570134; rs11420276; rs12092856; rs11403870; rs35257941; rs7528972; rs9803832; rs12746247; rs11588366; rs34439443; rs474273; rs12057673; rs10890275; rs11338876; rs12239224; rs10570133; rs6429636; rs4019074; rs6669306; rs12125897; rs10570131; rs12727638; rs11210902; rs35400929; rs12410444; rs12745143; rs12091846; rs35808450; rs12087260; rs35025872; rs1063216; rs6676093; rs813034; rs4019073; rs304304; rs12752141; rs36094772; rs12144625; rs10570132; rs11320852; rs35961828; rs7413917; rs12097684; rs11319068; rs12144603; rs35508020; rs11589270; rs7517769; rs12725938; rs216082; rs35660005; rs12067914; rs12725933; rs12410277; rs34077566; rs10749850; rs12747491; rs35532441; rs10698188; rs12141882; rs35891206; rs6680330; rs12070700; rs35438123; rs36010473; rs12741496; rs34402399; rs35962980; rs34379278; rs34983519; rs12410004; rs34172389; rs12124079; rs12760441; rs34879248; rs34813779; rs35302476; rs11457737; rs7418405; rs7543521; rs246774; rs34721057; rs12135624; rs34754704; rs3828142; rs10647059; rs813033; rs12410274; rs12725151; rs12124580; rs34208562; rs12747088; rs12747049; rs191016; rs35779604; rs7417619; rs11342279; rs34698304; rs11343844; rs35772564; rs3791079; rs34154596; rs3791105; rs12121688; rs35926127; rs11400892; rs11210929; rs12058552; rs6671186; rs2527778; rs2993621; rs12750105; rs37454; rs12410000; rs34742553; rs12083110; rs11210933; rs35550404; rs3094953; rs11390057; rs28435857; rs192774; rs34945138; rs35052091; rs1636877; rs34744295; rs2428959; rs35182002; rs11320873; rs35074436; rs35112818; rs12742772; rs35600599; rs12063414; rs2906456; rs12728059; rs35726867; rs35191997; rs35151641; rs35975333; rs12410278; rs3791075; rs12760568; rs12138824; rs2485995; rs3835022; rs10546799; rs12562885; rs34272247; rs2906469; rs3082973; rs12060557; rs34200388; rs34903296; rs35235321; rs6693624; rs3838470; rs12747100; rs35372849; rs3838467; rs2906459; rs28833034; rs12125928; rs34202649; rs6143206; rs35653403; rs813032; rs12032981; rs39722; rs7552570; rs35910755; rs35510675; rs12117550; rs34816934; rs34206966; rs34936975; rs5773813; rs7513994; rs11444647; rs34901992; rs35442154; rs2906464; rs12068966; rs12741160; rs12041341; rs12723311; rs34421303; rs12740440; rs35948825; rs12732520; rs12734798; rs35864694; rs12119115; rs10552484; rs34702534; rs34614818; rs35747575; rs35542895; rs35968623; rs12130582; rs4660756; rs2906472; rs10537119; rs12057653; rs34427804; rs35794459; rs12048584; rs2906460; rs12737134; rs12410275; rs12409998; rs11210921; rs5773814; rs12072491; rs35931965; rs11442409; rs12044961; rs4660746; rs1766964; rs7554860; rs12131706; rs34829905; rs36002915; rs10612057; rs12084315; rs12745841; rs6656224; rs12078063; rs12129369; rs1092193; rs28816524; rs34385208; rs12140180; rs34309699; rs34451408; rs4660744; rs3011230; rs3838466; rs28533013; rs36004035; rs2906598; rs11210923; rs10691786; rs246775; rs35232982; rs34264939; rs34857892; rs3011211; rs12068031; rs12725929; rs7511800; rs34193376; rs35722607; rs12563890; rs9660762; rs35572147; rs12562351; rs12410002; rs10553972; rs3838469; rs28705699; rs35794030; rs11440181; rs11402630; rs34771343; rs35618737; rs12068682; rs10692321; rs6679484; rs34473457; rs10616737; rs11270016; rs3791103; rs34790446; rs12724835; rs34992746; rs12410276; rs35466465; rs12724072; rs12733257; rs3011218; rs12409999; rs34826068; rs3124745; rs33958573; rs28411000; rs35589896; rs12409996; rs28407870; rs3838471; rs12733500; rs809748; rs12117162; rs6673211; rs34330931; rs35141408; rs12076111; rs12033036; rs12742616; rs3791044; rs35942856; rs35434192; rs803962; rs2906471; rs12085581; rs3791061; rs12747687; rs35314257; rs11356790; rs34847282; rs12410003; rs12084459; rs34733564; rs12116672; rs34960546; rs4147341; rs34256888; rs3838465; rs28405310; rs37461; rs10552483; rs35374353; rs3842543; rs11270209; rs11365894; rs12046114; rs6677990; rs7417507; rs34758067; rs12084380; rs12066540; rs5773815; rs12760449; rs12405939; rs35924747; rs34167272; rs12724083; rs3838468; rs12125699; rs12040333; rs35623985; rs3838472; rs34849461; rs811691; rs11811061; rs10676836; rs35545005; rs37455; rs37466; rs34489479; rs34224911; rs3791080; rs34587643; rs4660754; rs35897631; rs6696529; rs7539311; rs11310494; rs12410272; rs17474089; rs35937135; rs12410273; rs12745833; rs10675746; rs35010585; rs12723279; rs28496472; rs11357999; rs12117109; rs12750525; rs12138299; rs669609; rs34967646; rs12128663; rs4548485; rs11437483; rs12138823; rs11343074; rs35046955; rs2158956; rs4660748; rs10698139; rs7551551; rs34528572; rs35776840; rs37465; rs37467; rs11314443; rs7515061; rs1875652; rs34059956; rs6704464; rs12723491; rs2993618; rs5773816; rs3791054; rs12745848; rs3082975; rs35218617; rs6680338; rs4550096; rs12060558; rs12086715; rs10527918; rs34096962; rs35025013; rs12136010; rs3177617; rs1057125; rs12726706; rs14590; rs1548634; rs1766968; rs1859727; rs2240517; rs2242637; rs2428958; rs304302; rs34550543; rs34689902; rs3762419; rs3762421; rs3762422; rs3815268; rs7554073

# Metabolic_Enzyme_19_General_References:
8333853

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
6054

# Metabolic_Enzyme_20_Name:
Phosphatidylcholine:ceramide cholinephosphotransferase 1

# Metabolic_Enzyme_20_Synonyms:
Transmembrane protein 23; Sphingomyelin synthase 1; Protein Mob

# Metabolic_Enzyme_20_Gene_Name:
TMEM23

# Metabolic_Enzyme_20_Protein_Sequence:
>Phosphatidylcholine:ceramide cholinephosphotransferase 1
MLSASTMKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDFKKPPLCRVSS
DNGQRLLDMIETLKMEHHLEAHKNGHANGHLNIGVDIPTPDGSFSIKIKPNGMPNGYRKE
MIKIPMPELERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFF
DHFNRVQWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTT
LPVPGMHFNCSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYL
FIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQ
VLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLSRQVKYSRLVNDT

# Metabolic_Enzyme_20_Number_of_Residues:
419

# Metabolic_Enzyme_20_Molecular_Weight:
49208

# Metabolic_Enzyme_20_Theoretical_pI:
8.51

# Metabolic_Enzyme_20_GO_Classification:
Not Available

# Metabolic_Enzyme_20_General_Function:
Not Available

# Metabolic_Enzyme_20_Specific_Function:
Bidirectional lipid cholinephosphotransferases capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase

# Metabolic_Enzyme_20_Pathway:
Not Available

# Metabolic_Enzyme_20_Reaction:
Not Available

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00536:SAM_1

# Metabolic_Enzyme_20_Signals:
None

# Metabolic_Enzyme_20_Transmembrane_Regions:
142-162
190-210
221-241
282-302
310-330

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 2.7.8.27

# Metabolic_Enzyme_20_GenBank_ID_Protein:
30908857

# Metabolic_Enzyme_20_SwissProt_ID:
SMS1_HUMAN (Q86VZ5)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
TMEM23

# Metabolic_Enzyme_20_Geneatlas_id:
TMEM23

# Metabolic_Enzyme_20_hgnc_id:
HGNC:29799

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; multi-pass membrane protein

# Metabolic_Enzyme_20_Gene_Sequence:
>1242 bp
ATGAAGGAAGTGGTTTATTGGTCACCCAAGAAGGTGGCAGACTGGCTGCTGGAGAATGCT
ATGCCAGAATACTGTGAGCCTCTGGAGCATTTCACAGGCCAGGACTTGATCAACCTAACC
CAAGAGGATTTCAAAAAACCCCCCTTGTGCCGAGTCTCCTCTGACAACGGGCAGCGGCTC
CTGGACATGATAGAAACCCTGAAAATGGAGCACCATTTGGAAGCACACAAGAACGGCCAT
GCCAATGGGCACCTCAACATTGGCGTAGACATCCCCACCCCCGACGGCAGCTTCAGCATC
AAGATTAAACCCAACGGGATGCCAAATGGGTATAGGAAAGAGATGATAAAGATCCCCATG
CCAGAACTGGAGCGCTCTCAGTACCCCATGGAGTGGGGCAAGACTTTTCTGGCCTTTCTT
TATGCACTTTCCTGTTTCGTTCTCACCACAGTGATGATCTCGGTCGTCCACGAACGAGTA
CCTCCTAAGGAGGTGCAGCCTCCACTACCGGACACATTTTTTGACCATTTTAACCGGGTG
CAGTGGGCCTTTTCTATTTGTGAAATTAATGGCATGATCCTTGTAGGACTCTGGTTAATT
CAGTGGCTGCTCTTAAAATACAAGTCTATTATTAGCAGAAGATTTTTCTGCATAGTTGGC
ACGCTGTACCTGTATCGGTGTATTACAATGTATGTAACTACACTCCCAGTACCTGGTATG
CATTTCAACTGTTCTCCGAAGCTTTTCGGAGACTGGGAAGCCCAACTGCGAAGAATAATG
AAGCTCATTGCTGGAGGTGGCTTGTCTATCACTGGCTCTCACAACATGTGTGGGGACTAT
CTGTACAGCGGCCACACGGTCATGCTAACACTTACCTACTTATTTATCAAAGAGTATTCC
CCTCGGCGACTCTGGTGGTATCACTGGATTTGCTGGCTTCTCAGCGTAGTTGGAATCTTC
TGTATTCTCTTAGCGCATGACCACTACACTGTGGACGTGGTGGTGGCATATTACATCACC
ACGAGACTCTTCTGGTGGTATCACACTATGGCCAATCAGCAAGTGCTAAAGGAAGCTTCC
CAGATGAACCTCCTGGCCAGGGTGTGGTGGTACAGGCCATTTCAGTACTTTGAAAAGAAT
GTCCAAGGAATTGTACCTCGATCTTACCATTGGCCTTTCCCCTGGCCAGTAGTCCACCTC
AGTAGGCAAGTTAAATACAGCCGGCTGGTGAATGACACATAA

# Metabolic_Enzyme_20_GenBank_ID_Gene:
AY280959

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_20_Locus:
10q11.2

# Metabolic_Enzyme_20_SNPs:
rs10763354; rs1569962; rs2983357; rs1203380; rs1203421; rs910818; rs1203404; rs2983359; rs2574985; rs2983368; rs2339507; rs3011788; rs2842109; rs2574976; rs3011792; rs884880; rs2255849; rs2144862; rs1010930; rs1569963; rs2255720; rs1916572; rs1203398; rs14327; rs3011801; rs920136; rs2144863; rs927046; rs2688879; rs927047; rs2117958; rs910817; rs1548256; rs2099527; rs1203377; rs3011790; rs2221; rs3011710; rs3011770; rs2842105; rs2574956; rs1203405; rs1203410; rs1212555; rs1916566; rs1436211; rs3011791; rs2688884; rs6481252; rs2339401; rs9919413; rs7071603; rs7897345; rs4935173; rs7089882; rs4935711; rs10763587; rs10826242; rs3011782; rs10159614; rs3011773; rs3011781; rs10826118; rs10825995; rs1011881; rs10826166; rs10508929; rs4615973; rs2842110; rs11005937; rs11005720; rs1028534; rs1203375; rs1203393; rs978588; rs7070574; rs910819; rs4935733; rs1203386; rs7074764; rs10826014; rs1203391; rs2339505; rs7099450; rs7097359; rs2842103; rs10826243; rs2060560; rs2983360; rs10825779; rs4935738; rs1436206; rs1916568; rs7903649; rs10826169; rs3920545; rs7086029; rs10740762; rs2574955; rs1884570; rs10826149; rs10825903; rs7094655; rs10763373; rs1203418; rs7090807; rs6481273; rs7078284; rs7075289; rs10763566; rs11005614; rs10826234; rs768185; rs1865745; rs7909486; rs10826164; rs1203411; rs10508928; rs7075104; rs1884571; rs1210066; rs10082515; rs10763585; rs7077555; rs7893884; rs10740666; rs7893281; rs4935737; rs7067552; rs1203387; rs6481442; rs7100732; rs11005579; rs4935174; rs2339400; rs6481433; rs2144861; rs1203413; rs3011777; rs11006118; rs10826165; rs4935712; rs10826126; rs2983358; rs7096171; rs10825861; rs1203406; rs7916397; rs9299582; rs12358162; rs2842106; rs2064759; rs2339508; rs4935736; rs4935735; rs7477280; rs2983361; rs10763590; rs12265297; rs2983350; rs1203392; rs11005959; rs10490963; rs10826100; rs2273402; rs4935734; rs7093878; rs10825789; rs3739990; rs7923756; rs10763560; rs12573520; rs1203384; rs7097717; rs2339506; rs7088141; rs17179881; rs2983364; rs11006119; rs10763392; rs16906317; rs10826171; rs11006277; rs10825904; rs7920818; rs12260887; rs1203407; rs7900424; rs10218927; rs1203389; rs11006141; rs1203399; rs10490964; rs11814231; rs7068377; rs1203383; rs10826161; rs3011784; rs7904375; rs10160082; rs11006233; rs4517466; rs11005882; rs3011715; rs12358192; rs3011711; rs10508930; rs1203420; rs12358866; rs7898315; rs10826228; rs12356013; rs10763535; rs4935703; rs3011794; rs7096968; rs10508926; rs16906575; rs7082805; rs11006054; rs12360058; rs11005782; rs7069860; rs7094029; rs7092753; rs1203376; rs1203379; rs12569909; rs10825837; rs1203408; rs2339402; rs12355439; rs10826167; rs10508931; rs1203415; rs2842111; rs7078940; rs2574975; rs10508927; rs3802537; rs11005278; rs10825996; rs12261261; rs2983363; rs4935727; rs12358247; rs7916481; rs2983348; rs10763584; rs7922659; rs3011793; rs2255387; rs11005621; rs17581567; rs1203403; rs16937491; rs10826013; rs7068430; rs1369860; rs1203409; rs3011786; rs12572387; rs17496500; rs3011802; rs16906634; rs7908163; rs16934373; rs7900063; rs2574959; rs12219070; rs7093159; rs1203390; rs17721713; rs7072826; rs16937771; rs1916567; rs11005356; rs10825780; rs11006190; rs7067626; rs1740761; rs2255859; rs10763366; rs3011797; rs17721658; rs7904833; rs11005415; rs12569801; rs11814641; rs1203385; rs7097865; rs11006084; rs10763382; rs16937775; rs10825978; rs11006259; rs12219692; rs2983354; rs7915606; rs11006217; rs2842107; rs7077375; rs12415817; rs1203394; rs715675; rs2177372; rs4312019; rs12570382; rs2208036; rs11006114; rs7922802; rs10443954; rs927048; rs7082757; rs2860472; rs1203397; rs2255853; rs10763550; rs1720424; rs2208037; rs7092749; rs10763500; rs11595661; rs7090996; rs7918559; rs11005290; rs10763357; rs17581623; rs16906411; rs10218880; rs1210065; rs16906646; rs17496403; rs1884572; rs10825882; rs1203388; rs10826036; rs11005418; rs10826160; rs10826170; rs12262586; rs7921226; rs7096920; rs11006229; rs7907260; rs2064760; rs10763426; rs4519042; rs10826032; rs17721694; rs16937212; rs12246361; rs7916118; rs9988707; rs2117962; rs16930584; rs16937722; rs12413917; rs11005413; rs7073693; rs3011772; rs1203378; rs11591645; rs4268459; rs11816885; rs7071001; rs12249902; rs10733968; rs12571095; rs2983352; rs1203396; rs17438963; rs7916018; rs1203412; rs16906309; rs1810576; rs3011799; rs2224249; rs11006238; rs11005922; rs2339502; rs7921654; rs17519121; rs12415836; rs10740684; rs11819701; rs10826104; rs13376734; rs2983373; rs1916569; rs11005832; rs7923436; rs3011800; rs12219463; rs7086540; rs7911266; rs2339503; rs2024872; rs7903959; rs17438825; rs2983371; rs2117961; rs10826163; rs11005708; rs11006116; rs1203427; rs10763365; rs11006237; rs3011779; rs2983356; rs3011768; rs10825859; rs4519043; rs11005884; rs7094723; rs2983351; rs17440448; rs7907448; rs16937874; rs11815109; rs7923348; rs12249940; rs11006193; rs11006281; rs7073182; rs2688878; rs7896315; rs16934269; rs11005933; rs11006224; rs1203395; rs11816013; rs10826180; rs12413890; rs11005901; rs16906316; rs1203400; rs2574981; rs16914000; rs11006197; rs9988708; rs7094143; rs1211496; rs11005521; rs1740759; rs1203381; rs11005626; rs10825860; rs2208035; rs11005454; rs12262002; rs11006194; rs12356922; rs4935728; rs12415547; rs4935730; rs1203426; rs11005421; rs17518471; rs2983355; rs2983372; rs2983369; rs7092014; rs7908136; rs4935732; rs7080895; rs10826034; rs12263950; rs11593941; rs11006213; rs2860490; rs7079881; rs10763529; rs11005730; rs7922654; rs2688875; rs1203402; rs12414452; rs1898196; rs11005872; rs7069978; rs3011789; rs12569679; rs17497064; rs2983349; rs16937751; rs2339509; rs4536155; rs7921632; rs17179784; rs11006200; rs17778152; rs11006191; rs956794; rs7910356; rs2688874; rs2983362; rs7904620; rs10825825; rs7895767; rs7914683; rs16937319; rs10826101; rs12570244; rs12413362; rs11005399; rs7074405; rs2983346; rs7088807; rs12263501; rs7903503; rs12253262; rs7901132; rs10826159; rs12267134; rs16906349; rs17519380; rs7916013; rs3011787; rs7074024; rs3739989; rs12259463; rs12245522; rs2024873; rs11005286; rs7915777; rs10826033; rs7078136; rs2140406; rs2983365; rs10826105; rs11006155; rs2983353; rs1203374; rs11005345; rs7091881; rs7084809; rs12243444; rs12264817; rs11006288; rs7094446; rs12573569; rs3011776; rs16936658; rs1203382; rs7901006; rs873252; rs3011780; rs4935165; rs10826155; rs12217648; rs7099133; rs16930272; rs2574977; rs9416590; rs12244525; rs11005956; rs7914562; rs16937786; rs12264511; rs16931201; rs34672995; rs12261465; rs12265364; rs7914554; rs7902354; rs10825934; rs2092996; rs10740729; rs11006201; rs12257419; rs2842091; rs2251601; rs2246994; rs1436210; rs2177371; rs2842084; rs986315; rs2217899; rs2574978; rs2842096; rs1865746; rs1436215; rs2233778; rs1344848; rs2842094; rs7082941; rs2140407; rs2842090; rs11005193; rs10825665; rs4935623; rs7910519; rs10825740; rs12146309; rs11005212; rs4935617; rs7905772; rs2842086; rs7092981; rs7913957; rs1436214; rs2688886; rs10825729; rs4935618; rs7078238; rs10825753; rs7070330; rs2574979; rs2339415; rs10740654; rs4935616; rs2842089; rs2304443; rs2060561; rs11597397; rs7094121; rs17721080; rs1436213; rs7894586; rs17785945; rs10825754; rs4935605; rs11598794; rs7089536; rs1114039; rs12358176; rs1436212; rs7923694; rs2842085; rs2688885; rs11005241; rs7895250; rs7894861; rs2304444; rs11005213; rs16925365; rs2688881; rs11005245; rs12261584; rs2842088; rs12254110; rs2842087; rs12571721; rs17721187; rs7090022; rs17777710; rs11005204; rs12217518; rs7907477; rs17179735; rs2842093; rs2688880; rs11005262; rs2574980; rs12414270; rs2842097; rs4935624; rs6481183; rs12250028; rs7919474; rs11006358; rs12259181; rs12252843; rs35840264; rs2064761; rs11005595; rs11005538; rs11005981; rs12354779; rs33912501; rs34808309; rs1209146; rs11006012; rs12259376; rs4434946; rs11498129; rs5784833; rs34730112; rs13377042; rs34765489; rs11395568; rs3837302; rs7077862; rs12243987; rs35610090; rs3011712; rs34033095; rs3011795; rs7078085; rs28597717; rs12244472; rs35339061; rs36217695; rs12263443; rs11006168; rs11290410; rs10606517; rs2474611; rs11005443; rs12360512; rs10646459; rs36039844; rs35267910; rs3011767; rs34192399; rs11005624; rs9415526; rs34962870; rs1142039; rs11386761; rs12357518; rs7392702; rs35575354; rs35404095; rs1203424; rs34868032; rs12267811; rs7073468; rs35332938; rs3011778; rs34634961; rs12267585; rs7082728; rs28475404; rs11005779; rs11594062; rs35366077; rs35569088; rs35666475; rs35830236; rs7895102; rs2688877; rs7909624; rs1203401; rs35644704; rs4935713; rs11006219; rs35749954; rs3054272; rs2474612; rs5784831; rs35500210; rs12252767; rs11819203; rs10740714; rs35549947; rs12780505; rs2092997; rs11005803; rs34717216; rs35409405; rs35240090; rs7086507; rs12244961; rs3011708; rs17496089; rs11006177; rs12253887; rs12261287; rs35627486; rs7919169; rs12251163; rs34425441; rs11005459; rs956587; rs10564938; rs34904555; rs34368242; rs11005778; rs12251514; rs34268292; rs12243215; rs12265260; rs12262259; rs7083584; rs7905289; rs34048591; rs9415562; rs34472219; rs34070382; rs4935152; rs2983347; rs10524155; rs11516712; rs35016002; rs3011785; rs7475420; rs12245709; rs35900653; rs11006301; rs11443010; rs34095212; rs10625082; rs16906058; rs10588472; rs11282479; rs7911643; rs16905719; rs35120308; rs1203419; rs35866491; rs35626312; rs11006160; rs2024871; rs35208238; rs12412922; rs35628016; rs10527484; rs35839033; rs35737400; rs11006310; rs34575787; rs11006183; rs10458673; rs4630242; rs2461912; rs34659292; rs10535022; rs35580756; rs2574945; rs35479357; rs12359002; rs11398784; rs35054886; rs7083720; rs4935731; rs3011796; rs4935673; rs7908093; rs2842108; rs12570922; rs11382314; rs12777029; rs34160942; rs35130189; rs11005625; rs7069115; rs36028635; rs11006328; rs7914247; rs35979980; rs12098632; rs11006075; rs12777036; rs35694544; rs7895814; rs7912351; rs3011709; rs35617651; rs36053965; rs35801912; rs10570118; rs34649058; rs3011774; rs33968469; rs5784836; rs35096986; rs7897653; rs35205783; rs35144351; rs35255863; rs3054268; rs12240352; rs34323396; rs5784830; rs1044859; rs2064762; rs12243220; rs11006017; rs35188833; rs34773036; rs35592207; rs873979; rs34427152; rs35121553; rs10550886; rs4275569; rs35828568; rs36013034; rs12357733; rs34935845; rs9416516; rs9416652; rs35401234; rs12250088; rs11005502; rs3054273; rs11005281; rs11005946; rs16931872; rs9416613; rs34884352; rs35495186; rs12253726; rs35297903; rs9943298; rs35974932; rs7898720; rs1060728; rs35798141; rs2842100; rs11005304; rs36087777; rs12262654; rs12243860; rs11006180; rs35545360; rs12252248; rs2983366; rs34384810; rs7358033; rs2842102; rs34847074; rs2339504; rs34313644; rs12252024; rs35374124; rs12255967; rs5784835; rs35680490; rs10581530; rs12414030; rs35987908; rs34761337; rs36075516; rs11409976; rs34496581; rs11005920; rs36030853; rs16937137; rs34143179; rs12246357; rs28438372; rs7912234; rs12241198; rs11006152; rs11005631; rs11005316; rs11005450; rs34533586; rs7085876; rs11469024; rs1916571; rs3054244; rs34152379; rs11005780; rs9919407; rs35856795; rs34492807; rs11006161; rs35592571; rs7096639; rs11005661; rs1203423; rs34561313; rs11006222; rs11397144; rs35366400; rs4540795; rs34029952; rs11005761; rs2204249; rs3029141; rs35940464; rs3011775; rs4420209; rs34994822; rs12263463; rs34678593; rs11006166; rs10047363; rs35966514; rs12241031; rs12763713; rs1213002; rs2983367; rs2842099; rs10600254; rs11005703; rs34512906; rs3029167; rs16937517; rs11005293; rs11592055; rs35948763; rs34192845; rs10652848; rs34753541; rs35380353; rs34106260; rs1203414; rs12249770; rs10550885; rs35896564; rs34318186; rs10670074; rs35531768; rs12265262; rs7910282; rs34228488; rs35091719; rs2117960; rs1203417; rs2688883; rs35485360; rs34666139; rs34928652; rs34123058; rs10639225; rs10619225; rs17497203; rs34706801; rs35532583; rs12766096; rs4935729; rs16906546; rs35642306; rs12251096; rs11005877; rs12243240; rs2688876; rs11005612; rs12217652; rs35844158; rs11005539; rs11005972; rs12249054; rs34629898; rs34122137; rs12262564; rs34714556; rs12217916; rs34715705; rs11006181; rs34670428; rs34750662; rs11006073; rs11555525; rs34161084; rs10678352; rs11424535; rs12569826; rs1203425; rs35160052; rs12770708; rs1211373; rs2983370; rs3011707; rs34375381; rs12780521; rs12260642; rs34029106; rs35489210; rs10607649; rs11289602; rs12241613; rs35133891; rs34160216; rs34403054; rs3029134; rs12263729; rs34960612; rs34830879; rs3011771; rs7096280; rs11006185; rs34715045; rs5784834; rs16937779; rs11005952; rs12261460; rs34444234; rs12265604; rs12570651; rs11483966; rs36122110; rs34213132; rs12266187; rs4128326; rs1880071; rs11390301; rs3011783; rs3011766; rs33980668; rs7074349; rs12780513; rs11005934; rs34773627; rs11005387; rs12775936; rs11005910; rs3054271; rs11005414; rs1898197; rs12762818; rs10549824; rs11005812; rs35143956; rs34057318; rs1916570; rs34155132; rs12243876; rs34857185; rs11355595; rs1203422; rs7915490; rs34151863; rs1203416; rs35233606; rs11006102; rs5784832; rs12767636; rs11006089; rs7899832; rs11005321; rs11005585; rs11818331; rs11006029; rs5784837; rs34464851; rs11006134; rs11005875; rs35665201; rs11006216; rs12415575; rs7080963; rs35240773; rs11316457; rs11006179; rs1203361; rs35999768; rs12354429; rs1436208; rs7342075; rs34732501; rs4360653; rs41275244; rs7905084; rs12049742; rs2461914; rs11270643; rs41274642; rs34871473; rs12779362; rs28524002; rs34696945; rs16927378; rs2494982; rs2494981; rs34427800; rs34173381; rs7079563; rs1836836; rs2461913; rs35953180; rs5784829; rs41427847; rs34369700; rs6143895; rs2842095; rs10678162; rs35491989; rs7095681; rs2842092; rs11005191; rs1212234; rs11591247; rs2233779; rs7342071; rs35855176; rs7342074; rs11372700; rs36006030; rs12411302; rs11005215; rs10591253; rs956988; rs10580433; rs34417441; rs1436209; rs34340536; rs7342076; rs7076545; rs34715739; rs41417550; rs9416518; rs35253584; rs2688882; rs2461915; rs35408706; rs11273448; rs4935615; rs12763325; rs11005061; rs11376088; rs7904446; rs12763727; rs11414281; rs12763503; rs12763330; rs12779175; rs34567684; rs12248247; rs35160330; rs10740635; rs10826273; rs11006369; rs11814710; rs12247712; rs12258709; rs12571898; rs4475874; rs7081307; rs7093046; rs7093195; rs7904101

# Metabolic_Enzyme_20_General_References:
Not Available

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
5313

# Metabolic_Enzyme_21_Name:
Ectonucleoside triphosphate diphosphohydrolase 1

# Metabolic_Enzyme_21_Synonyms:
NTPDase 1; Ecto-ATP diphosphohydrolase; ATPDase; Lymphoid cell activation antigen; Ecto-apyrase; CD39 antigen

# Metabolic_Enzyme_21_Gene_Name:
ENTPD1

# Metabolic_Enzyme_21_Protein_Sequence:
>Ectonucleoside triphosphate diphosphohydrolase 1
MEDTKESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENVKYGIVLDAGSSHT
SLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQ
HQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWI
TINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFR
LYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTP
CTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAF
SAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYIL
SLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVFL
MVLFSLVLFTVAIIGLLIFHKPSYFWKDMV

# Metabolic_Enzyme_21_Number_of_Residues:
510

# Metabolic_Enzyme_21_Molecular_Weight:
57965

# Metabolic_Enzyme_21_Theoretical_pI:
6.29

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Not Available

# Metabolic_Enzyme_21_Specific_Function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation. Hydrolyzes ATP and ADP equally well

# Metabolic_Enzyme_21_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_21_Reaction:
ATP + 2 H2O = AMP + 2 phosphate

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF01150:GDA1_CD39

# Metabolic_Enzyme_21_Signals:
None

# Metabolic_Enzyme_21_Transmembrane_Regions:
17-37
479-499

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 3.6.1.5

# Metabolic_Enzyme_21_GenBank_ID_Protein:
765256

# Metabolic_Enzyme_21_SwissProt_ID:
ENTP1_HUMAN (P49961)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
ENTPD1

# Metabolic_Enzyme_21_Geneatlas_id:
ENTPD1

# Metabolic_Enzyme_21_hgnc_id:
HGNC:3363

# Metabolic_Enzyme_21_PDB_ID:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential)

# Metabolic_Enzyme_21_Gene_Sequence:
>1533 bp
ATGGAAGATACAAAGGAGTCTAACGTGAAGACATTTTGCTCCAAGAATATCCTAGCCATC
CTTGGCTTCTCCTCTATCATAGCTGTGATAGCTTTGCTTGCTGTGGGGTTGACCCAGAAC
AAAGCATTGCCAGAAAACGTTAAGTATGGGATTGTGCTGGATGCGGGTTCTTCTCACACA
AGTTTATACATCTATAAGTGGCCAGCAGAAAAGGAGAATGACACAGGCGTGGTGCATCAA
GTAGAAGAATGCAGGGTTAAAGGTCCTGGAATCTCAAAATTTGTTCAGAAAGTAAATGAA
ATAGGCATTTACCTGACTGATTGCATGGAAAGAGCTAGGGAAGTGATTCCAAGGTCCCAG
CACCAAGAGACACCCGTTTACCTGGGAGCCACGGCAGGCATGCGGTTGCTCAGGATGGAA
AGTGAAGAGTTGGCAGACAGGGTTCTGGATGTGGTGGAGAGGAGCCTCAGCAACTACCCC
TTTGACTTCCAGGGTGCCAGGATCATTACTGGCCAAGAGGAAGGTGCCTATGGCTGGATT
ACTATCAACTATCTGCTGGGCAAATTCAGTCAGAAAACAAGGTGGTTCAGCATAGTCCCA
TATGAAACCAATAATCAGGAAACCTTTGGAGCTTTGGACCTTGGGGGAGCCTCTACACAA
GTCACTTTTGTACCCCAAAACCAGACTATCGAGTCCCCAGATAATGCTCTGCAATTTCGC
CTCTATGGCAAGGACTACAATGTCTACACACATAGCTTCTTGTGCTATGGGAAGGATCAG
GCACTCTGGCAGAAACTGGCCAAGGACATTCAGGTTGCAAGTAATGAAATTCTCAGGGAC
CCATGCTTTCATCCTGGATATAAGAAGGTAGTGAACGTAAGTGACCTTTACAAGACCCCC
TGCACCAAGAGATTTGAGATGACTCTTCCATTCCAGCAGTTTGAAATCCAGGGTATTGGA
AACTATCAACAATGCCATCAAAGCATCCTGGAGCTCTTCAACACCAGTTACTGCCCTTAC
TCCCAGTGTGCCTTCAATGGGATTTTCTTGCCACCACTCCAGGGGGATTTTGGGGCATTT
TCAGCTTTTTACTTTGTGATGAAGTTTTTAAACTTGACATCAGAGAAAGTCTCTCAGGAA
AAGGTGACTGAGATGATGAAAAAGTTCTGTGCTCAGCCTTGGGAGGAGATAAAAACATCT
TACGCTGGAGTAAAGGAGAAGTACCTGAGTGAATACTGCTTTTCTGGTACCTACATTCTC
TCCCTCCTTCTGCAAGGCTATCATTTCACAGCTGATTCCTGGGAGCACATCCATTTCATT
GGCAAGATCCAGGGCAGCGACGCCGGCTGGACTTTGGGCTACATGCTGAACCTGACCAAC
ATGATCCCAGCTGAGCAACCATTGTCCACACCTCTCTCCCACTCCACCTATGTCTTCCTC
ATGGTTCTATTCTCCCTGGTCCTTTTCACAGTGGCCATCATAGGCTTGCTTATCTTTCAC
AAGCCTTCATATTTCTGGAAAGATATGGTATAG

# Metabolic_Enzyme_21_GenBank_ID_Gene:
S73813

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_21_Locus:
10q24

# Metabolic_Enzyme_21_SNPs:
rs3793744; rs3181132; rs1342790; rs3176883; rs3181124; rs1573112; rs3176891; rs2153913; rs3176890; rs10748643; rs7077566; rs4431963; rs6584033; rs4582902; rs10882665; rs6584026; rs2185818; rs10748649; rs4075310; rs3176881; rs5014871; rs7097489; rs7919196; rs4481960; rs4918968; rs10882664; rs1891534; rs7096610; rs10509686; rs7083960; rs4322324; rs3892344; rs3181123; rs4396219; rs4512761; rs4917715; rs7921242; rs7074403; rs1891536; rs4244321; rs2861152; rs1418709; rs3181131; rs2275759; rs4075311; rs10882671; rs4917714; rs1340837; rs6584027; rs3176885; rs7088952; rs12262943; rs11598475; rs4320886; rs17111156; rs11188486; rs10882676; rs7096248; rs3929900; rs4918969; rs4551688; rs7093453; rs3897983; rs2901874; rs10882673; rs4918971; rs2901873; rs2861153; rs6584031; rs10736092; rs7893677; rs3181129; rs4917707; rs11188497; rs7088961; rs7902190; rs10882660; rs2105359; rs6584028; rs7901116; rs7913082; rs10736093; rs3176884; rs7900927; rs4614366; rs10786236; rs2901872; rs7067762; rs11188485; rs7089668; rs4409759; rs7070507; rs11595122; rs10882670; rs10786235; rs1539433; rs7100137; rs7088584; rs11818540; rs10748648; rs4336964; rs10882675; rs1342791; rs4074424; rs4918970; rs3181122; rs12767650; rs3901451; rs11816167; rs11188475; rs3181121; rs7915345; rs3176887; rs2861151; rs6584030; rs4412693; rs11594340; rs7921000; rs7894940; rs3176882; rs7898379; rs11188496; rs3181118; rs3176886; rs10882661; rs10882666; rs7901386; rs2275760; rs7090320; rs12770849; rs3181125; rs7915682; rs3901450; rs11188501; rs10786237; rs7900546; rs10748644; rs10786234; rs7915087; rs7913018; rs7894676; rs7914736; rs1935816; rs1418710; rs10748645; rs10786233; rs7069234; rs4406763; rs10882662; rs11188502; rs7915308; rs3176889; rs7095489; rs11593761; rs7082531; rs7914286; rs2861154; rs7083411; rs3176888; rs10882663; rs7920372; rs10748647; rs12780375; rs12354848; rs7476775; rs11188484; rs11188495; rs12763743; rs10882668; rs4272738; rs11188488; rs7900841; rs7921302; rs11188492; rs10786238; rs12244606; rs7915499; rs10882669; rs11188498; rs7904990; rs11592584; rs12770313; rs10882674; rs11188504; rs3181127; rs7915380; rs3176894; rs3814159; rs3176893; rs3176895; rs3176892; rs1804825; rs12240959; rs4463786; rs34293555; rs34399092; rs35135296; rs11389794; rs3980180; rs10736091; rs11407296; rs11188487; rs11597953; rs11188493; rs5787157; rs4472866; rs4539246; rs34736818; rs34473397; rs35488296; rs35597960; rs4420188; rs35620983; rs5787162; rs9663685; rs35826614; rs7900437; rs34166835; rs10585205; rs11188508; rs34177114; rs36017526; rs3181128; rs10672739; rs4581382; rs5787158; rs12354620; rs12265109; rs11188494; rs11188482; rs4433506; rs34836127; rs34248770; rs35444953; rs35537802; rs3980181; rs34907927; rs35452058; rs34858625; rs7896855; rs35809029; rs11517041; rs11188479; rs35615283; rs34279173; rs12360382; rs34421483; rs34720050; rs34980662; rs35782220; rs11574649; rs11393527; rs7909739; rs7088411; rs12572063; rs34872816; rs12258207; rs5787161; rs11188481; rs11188511; rs28542865; rs35164560; rs4917705; rs7900229; rs11527887; rs35203111; rs3897464; rs34082135; rs34627984; rs35360884; rs11188509; rs34308669; rs35650706; rs11188506; rs4325249; rs35298724; rs35859772; rs11188510; rs5787159; rs1418711; rs11574648; rs34367283; rs34925455; rs34296389; rs11188480; rs11528098; rs34873600; rs7898964; rs34863917; rs11188489; rs34997042; rs3961946; rs35748815; rs35177231; rs12357414; rs11188490; rs12355114; rs34077465; rs35535706; rs35825117; rs35417010; rs9702308; rs4481957; rs35854596; rs11188505; rs7911911; rs5787163; rs34850860; rs12782273; rs11188477; rs11188491; rs12774334; rs3897465; rs11188473; rs9664384; rs11188503; rs33998152; rs11188483; rs4402217; rs35861909; rs35700869; rs3961947; rs35516259; rs11498722; rs5787160; rs34143181; rs10736094; rs11188466; rs11188469; rs11188471; rs11188512; rs11188513; rs11188514; rs12358481; rs12761960; rs12775598; rs12781189; rs17462179; rs17553401; rs1935815; rs2051052; rs2096218; rs2153914; rs2226163; rs3181114; rs3181115; rs3181116; rs3192654; rs34630379; rs34793678; rs4918966; rs6584022; rs6584023; rs7086986; rs7090630; rs7096317; rs7098750; rs7100644; rs7923971

# Metabolic_Enzyme_21_General_References:
7930580; 8996251; 10405171; 8529670; 9846014; 8955160; 8626624; 10636909

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
8538

# Metabolic_Enzyme_22_Name:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

# Metabolic_Enzyme_22_Synonyms:
GalNAc alpha-2,6-sialyltransferase III; ST6GalNAc III; Sialyltransferase 7C; STY

# Metabolic_Enzyme_22_Gene_Name:
ST6GALNAC3

# Metabolic_Enzyme_22_Protein_Sequence:
>AlphaNacetylgalactosaminide alpha2,6sialyltransferase 3
MACILKRKSVIAVSFIAAFLFLLVVRLVNEVNFPLLLNCFGQPGTKWIPFSYTYRRPLRT
HYGYINVKTQEPLQLDCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVG
RMTMIRVVSHTSVPLLLKNPDYFFKEANTTIYVIWGPFRNMRKDGNGIVYNMLKKTVGIY
PNAQIYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTGWFTFLLAMDACYGIHVYGMIND
TYCKTEGYRKVPYHYYEQGRDECDEYFLHEHAPYGGHRFITEKKVFAKWAKKHRIIFTHP
NWTLS

# Metabolic_Enzyme_22_Number_of_Residues:
305

# Metabolic_Enzyme_22_Molecular_Weight:
35395

# Metabolic_Enzyme_22_Theoretical_pI:
9.38

# Metabolic_Enzyme_22_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  sialyltransferase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  intrinsic to organelle membrane
Component:  intrinsic to Golgi membrane
Component:  integral to Golgi membrane

# Metabolic_Enzyme_22_General_Function:
Not Available

# Metabolic_Enzyme_22_Specific_Function:
Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins

# Metabolic_Enzyme_22_Pathway:
Not Available

# Metabolic_Enzyme_22_Reaction:
Not Available

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF00777:Glyco_transf_29

# Metabolic_Enzyme_22_Signals:
1-30

# Metabolic_Enzyme_22_Transmembrane_Regions:
9-28

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 2.4.99.-

# Metabolic_Enzyme_22_GenBank_ID_Protein:
22799094

# Metabolic_Enzyme_22_SwissProt_ID:
SIA7C_HUMAN (Q8NDV1)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
ST6GALNAC3

# Metabolic_Enzyme_22_Geneatlas_id:
ST6GALNAC3

# Metabolic_Enzyme_22_hgnc_id:
HGNC:19343

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Potential)

# Metabolic_Enzyme_22_Gene_Sequence:
>918 bp
ATGGCCTGCATCCTGAAGAGAAAGTCTGTGATTGCTGTGAGCTTCATAGCAGCGTTCCTT
TTCCTGCTGGTTGTGCGTCTTGTAAATGAAGTGAATTTCCCATTGCTACTAAACTGCTTT
GGACAACCTGGTACAAAGTGGATACCATTCTCCTACACATACAGGCGGCCCCTTCGAACT
CACTATGGATACATAAATGTGAAGACACAAGAGCCTTTGCAACTGGACTGTGACCTTTGT
GCCATAGTGTCAAACTCAGGTCAGATGGTTGGCCAGAAGGTGGGAAATGAGATAGATCGA
TCCTCCTGCATTTGGAGAATGAACAATGCCCCCACCAAAGGTTATGAAGAAGATGTCGGC
CGCATGACCATGATTCGAGTTGTGTCCCATACCAGCGTTCCTCTTTTGCTAAAAAACCCT
GATTATTTTTTCAAGGAAGCGAATACTACTATTTATGTTATTTGGGGACCTTTCCGCAAT
ATGAGGAAAGATGGCAATGGCATCGTTTACAACATGTTGAAAAAGACAGTTGGTATCTAT
CCGAATGCCCAAATATACGTGACCACAGAGAAGCGCATGAGTTACTGTGATGGAGTTTTT
AAGAAGGAAACTGGGAAGGACAGAGTCCAGTCTGGCTCATATCTCAGCACAGGGTGGTTT
ACCTTCCTTCTGGCCATGGACGCCTGTTATGGCATTCACGTCTACGGGATGATAAATGAC
ACCTACTGCAAGACAGAAGGGTATAGAAAAGTCCCCTACCATTATTATGAACAAGGAAGA
GATGAGTGTGATGAATATTTTCTTCATGAACATGCCCCATATGGGGGTCATAGGTTTATC
ACTGAAAAGAAAGTGTTTGCTAAATGGGCCAAGAAGCACAGGATAATATTTACACATCCA
AACTGGACATTGTCTTGA

# Metabolic_Enzyme_22_GenBank_ID_Gene:
AJ507291

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_22_Locus:
1p31.1

# Metabolic_Enzyme_22_SNPs:
rs1184626; rs17098940; rs9970671; rs650427; rs676269; rs12403583; rs12125529; rs2893412; rs2647389; rs1335738; rs923246; rs923245; rs533097; rs315027; rs549014; rs341027; rs945364; rs289677; rs432980; rs3011994; rs434302; rs627873; rs369258; rs407271; rs403493; rs1251576; rs315065; rs503329; rs481510; rs531773; rs1144346; rs1414476; rs923244; rs2133177; rs341028; rs341022; rs560520; rs1251577; rs544858; rs315091; rs315037; rs341023; rs512082; rs2117905; rs289697; rs479650; rs387831; rs490570; rs522414; rs1414479; rs1144345; rs315087; rs2152388; rs860154; rs371490; rs638593; rs2764654; rs289700; rs1408866; rs1414482; rs341020; rs491409; rs315034; rs315063; rs486453; rs289696; rs341024; rs1537782; rs1999734; rs485141; rs563885; rs2647392; rs366825; rs289701; rs580928; rs1325287; rs391393; rs643289; rs289685; rs2147791; rs158620; rs315035; rs1537784; rs1335862; rs1369804; rs573657; rs1889751; rs1318243; rs1335740; rs2067914; rs569850; rs3011989; rs2631779; rs315030; rs2992502; rs315090; rs751182; rs315040; rs184095; rs4576696; rs7553137; rs12128122; rs2706192; rs370808; rs401290; rs315031; rs10873890; rs6703692; rs12124554; rs4245647; rs664678; rs6681765; rs4949632; rs11800951; rs7521939; rs1325286; rs7536778; rs4620587; rs11162113; rs438166; rs315043; rs289686; rs172714; rs6593544; rs315014; rs11162105; rs315093; rs289698; rs315013; rs588073; rs409936; rs434587; rs4447031; rs3884182; rs915404; rs315079; rs1414480; rs4511169; rs2574775; rs1486933; rs6664863; rs3011990; rs12072202; rs613909; rs7513970; rs472536; rs384044; rs551269; rs1369805; rs417932; rs12144344; rs7530637; rs501426; rs394007; rs6688662; rs765930; rs7534588; rs519835; rs3903914; rs10782617; rs1002451; rs6593534; rs427589; rs12742877; rs1016715; rs1335737; rs1436085; rs10218698; rs6691055; rs315049; rs3862899; rs289678; rs572623; rs638947; rs315028; rs4290110; rs315042; rs315044; rs3862903; rs2147792; rs170260; rs417415; rs1540964; rs7528680; rs315082; rs167050; rs370016; rs12142643; rs221521; rs1952021; rs425110; rs571399; rs12123760; rs3862900; rs11162183; rs1146663; rs1473472; rs11162087; rs2392038; rs6593549; rs172358; rs10493584; rs289693; rs915403; rs7550651; rs3011997; rs11162148; rs315036; rs10218675; rs2210832; rs2209458; rs522935; rs315026; rs315018; rs315073; rs502421; rs4949625; rs367208; rs11162125; rs7539896; rs190861; rs12239582; rs315066; rs4480406; rs1537783; rs6593525; rs11162180; rs7555277; rs315068; rs366469; rs10873873; rs1173686; rs10873893; rs11162150; rs548691; rs1002450; rs883352; rs1486935; rs4949623; rs315088; rs4949634; rs1347539; rs2893416; rs289692; rs4353143; rs11162091; rs984528; rs7546379; rs315019; rs341025; rs1146664; rs1925359; rs178353; rs402394; rs1002448; rs680970; rs6699746; rs1360878; rs665178; rs3843263; rs4421636; rs158621; rs7528766; rs572581; rs2043799; rs6685141; rs2392036; rs7536455; rs11162104; rs592872; rs289687; rs1414486; rs376878; rs399529; rs645124; rs10873869; rs2952435; rs1486932; rs1570823; rs1144344; rs915402; rs2087137; rs7418063; rs186397; rs4949702; rs1146660; rs10747346; rs4300269; rs423480; rs4949706; rs12079387; rs4949718; rs6593533; rs7531146; rs6672694; rs1251568; rs572200; rs2706193; rs6593538; rs6678598; rs11162100; rs10782609; rs291059; rs1325289; rs11162119; rs392194; rs536913; rs2392030; rs10782626; rs1251575; rs442486; rs1359468; rs419725; rs315067; rs1414483; rs12046510; rs7340082; rs7513539; rs6670463; rs7515898; rs315076; rs6661158; rs315078; rs12039112; rs518915; rs6593526; rs315021; rs4949711; rs12408886; rs11162090; rs2035611; rs4357574; rs544010; rs6689933; rs6696780; rs341019; rs1932259; rs2706195; rs4478861; rs12123144; rs12028135; rs1486934; rs6700215; rs3884183; rs6677296; rs180467; rs12068326; rs4949719; rs7521965; rs10873878; rs1486931; rs10493589; rs11162096; rs12048928; rs1359467; rs11162135; rs315080; rs519797; rs2893415; rs877017; rs11162144; rs167557; rs10747347; rs6593527; rs17678977; rs4342892; rs11162157; rs2952434; rs12125121; rs289682; rs17098942; rs12744538; rs1414484; rs11162159; rs604078; rs11162143; rs1144343; rs4336900; rs12081001; rs12078910; rs6421755; rs12057582; rs1414403; rs3904687; rs6689490; rs505796; rs10873881; rs2783657; rs315081; rs9437402; rs436806; rs12140157; rs6692547; rs12085592; rs7544496; rs4565767; rs439624; rs2225784; rs12069012; rs315083; rs11805668; rs597362; rs1952022; rs6675148; rs9803953; rs11803647; rs4459158; rs450133; rs482598; rs7518384; rs6657540; rs4408196; rs12067841; rs11807247; rs10782620; rs2783985; rs315041; rs10735745; rs1414481; rs7547383; rs17098975; rs2392034; rs751183; rs11162147; rs11162084; rs2783988; rs6664614; rs11162164; rs6700771; rs1436088; rs10493586; rs7530833; rs12075927; rs4949633; rs7525997; rs7528649; rs315022; rs6685154; rs12562911; rs6593541; rs10873874; rs6688867; rs172334; rs11809814; rs1325292; rs10128020; rs7539513; rs409245; rs4949624; rs1408867; rs12140182; rs11162132; rs10873866; rs12354033; rs11162117; rs6675095; rs7546140; rs622212; rs6421756; rs315009; rs6693031; rs11162118; rs17098341; rs10873891; rs11162128; rs4638174; rs9437150; rs12069137; rs12407011; rs315025; rs11801014; rs10493583; rs7531740; rs17098996; rs11585383; rs10873867; rs1251570; rs10493590; rs17610851; rs315032; rs4607942; rs7540736; rs11162121; rs50564; rs12734622; rs9437408; rs11805218; rs11162138; rs4949722; rs11162158; rs289683; rs11803060; rs486115; rs547342; rs11803955; rs4622117; rs4245652; rs3904686; rs1325291; rs11806146; rs6593543; rs6702605; rs11806042; rs11162174; rs7556363; rs1359471; rs413350; rs11577339; rs17098999; rs11806270; rs315051; rs10782619; rs7550713; rs11582447; rs517017; rs11586933; rs7554005; rs4949629; rs538977; rs3862905; rs10218683; rs410076; rs12046895; rs315011; rs10493587; rs7531105; rs11809249; rs12073733; rs12079106; rs6593537; rs10873887; rs11162137; rs7524886; rs6702844; rs12403092; rs1251569; rs1002449; rs7536613; rs534156; rs10873892; rs1325297; rs11162092; rs11162146; rs7526631; rs4949705; rs17098450; rs12063002; rs12408380; rs12077082; rs17098336; rs1547340; rs1540963; rs289674; rs315094; rs12021906; rs432956; rs12066794; rs1414485; rs12130103; rs7526478; rs2031482; rs4598537; rs752819; rs2893414; rs315012; rs1335863; rs12756608; rs12138475; rs17098338; rs6691403; rs12064337; rs517036; rs12025413; rs2706202; rs7529530; rs17098431; rs3884184; rs289679; rs17629536; rs289684; rs3916214; rs6665168; rs7339997; rs3920772; rs12064344; rs10782611; rs11577619; rs6691913; rs1601640; rs4405171; rs12753314; rs11162139; rs1325296; rs315095; rs7413797; rs3011996; rs4628548; rs6691344; rs315020; rs1414406; rs10873872; rs315077; rs17099155; rs11162086; rs17660531; rs4949710; rs12137581; rs6667721; rs315057; rs6695042; rs532296; rs4949626; rs12117865; rs315084; rs817822; rs12074693; rs11804754; rs12133165; rs315029; rs11162130; rs17627406; rs7548049; rs315023; rs664998; rs1570825; rs12563748; rs2893413; rs12409247; rs942699; rs12029184; rs1325290; rs7541103; rs17098511; rs17610084; rs3862895; rs163603; rs1684945; rs505931; rs6673424; rs10493585; rs12128783; rs17631994; rs1251464; rs600746; rs392809; rs341029; rs11162095; rs17098335; rs10873876; rs4949631; rs17098150; rs2992503; rs10493588; rs12135053; rs12096789; rs425149; rs1581799; rs1591472; rs12076310; rs435004; rs10873883; rs7516589; rs3862901; rs3011995; rs6660107; rs315060; rs17098324; rs11162099; rs4949716; rs7514776; rs12077146; rs7524669; rs4949697; rs12058124; rs12136538; rs12088871; rs413540; rs315089; rs4949715; rs10873889; rs9803980; rs315046; rs6664446; rs12562880; rs7542154; rs17098418; rs699829; rs209256; rs12755056; rs6683724; rs17099267; rs402112; rs1763465; rs12089419; rs11162089; rs12096348; rs4949696; rs11807801; rs4083857; rs1146665; rs6684849; rs7516680; rs11162136; rs12407031; rs915335; rs566665; rs4300268; rs3851267; rs6688136; rs10873875; rs4949724; rs7544201; rs12132707; rs1124171; rs12143452; rs7514851; rs10518526; rs6673468; rs7540069; rs11162127; rs341026; rs11585239; rs12124295; rs6662992; rs17670910; rs565352; rs12060625; rs4949627; rs12136476; rs4364924; rs1436087; rs473380; rs2631796; rs11162170; rs4290109; rs12757663; rs403449; rs6593532; rs10493582; rs10493591; rs603022; rs12122625; rs4949707; rs315039; rs6702923; rs552890; rs11162165; rs619283; rs11162094; rs12048024; rs289695; rs10782614; rs12733869; rs864205; rs11162083; rs1970226; rs315017; rs17631958; rs11801997; rs546786; rs7541737; rs4949728; rs4288643; rs12058465; rs11805415; rs1325294; rs9437437; rs11162098; rs12408918; rs1436084; rs2631795; rs289690; rs11162171; rs10782606; rs404652; rs4369272; rs2631782; rs4495763; rs11162120; rs434633; rs341021; rs1498367; rs6698059; rs4253954; rs12095328; rs12075814; rs6672033; rs17098252; rs580390; rs4426021; rs11809748; rs11586810; rs11807459; rs17098736; rs7550790; rs12138975; rs12562698; rs12755567; rs6697478; rs6700436; rs2783661; rs527924; rs7549935; rs2082916; rs2631789; rs11162114; rs17099004; rs17099095; rs17098768; rs1002784; rs17627816; rs6593542; rs1631357; rs429265; rs551954; rs17609913; rs6663343; rs11162169; rs17098353; rs12736289; rs11804346; rs12082025; rs4949717; rs4515842; rs17098419; rs11803608; rs1414487; rs11801656; rs12067514; rs17098457; rs12407837; rs11584597; rs11162093; rs9437445; rs6694998; rs167049; rs289694; rs17099105; rs1146662; rs17098764; rs1684948; rs4949700; rs12725311; rs12138578; rs17609832; rs11804628; rs12073910; rs6686196; rs13376004; rs423152; rs7531473; rs11807262; rs12734534; rs12407614; rs4636520; rs12031035; rs17626410; rs12132439; rs10873870; rs315010; rs7542080; rs4517397; rs4344371; rs12122853; rs12725146; rs12034783; rs7539009; rs7528463; rs17098332; rs6593524; rs11804738; rs7521427; rs441806; rs12085320; rs384639; rs1359469; rs9437448; rs483441; rs11804103; rs7547235; rs12756101; rs34386885; rs1547341; rs17098550; rs1570827; rs12733453; rs10873885; rs12124525; rs9437406; rs11806300; rs17098357; rs17098603; rs1251806; rs315048; rs167556; rs11162162; rs6673488; rs12405655; rs11806763; rs12740580; rs4262595; rs3891339; rs17098064; rs549195; rs1093559; rs2706181; rs17099040; rs1586417; rs12734853; rs574130; rs17098330; rs17098776; rs11162168; rs17098690; rs12749473; rs7512081; rs2065795; rs2631781; rs409979; rs12239615; rs2706179; rs11162142; rs315033; rs6667200; rs12754064; rs411756; rs4459157; rs11162112; rs17098360; rs4568877; rs12742405; rs574927; rs2631793; rs17098132; rs12079890; rs12040892; rs11162109; rs12035017; rs1032185; rs9437395; rs17660872; rs17098326; rs17098772; rs2392033; rs17098852; rs17682325; rs3011988; rs315062; rs17626669; rs7537853; rs7519787; rs4335414; rs11805688; rs6697235; rs439923; rs11581788; rs11811944; rs17099099; rs11810865; rs11590555; rs4949630; rs17099209; rs508072; rs9437137; rs12084124; rs17098448; rs178354; rs681280; rs35172229; rs9700636; rs11802749; rs17609727; rs11162116; rs12143779; rs12731715; rs2647390; rs12137229; rs11162167; rs4949701; rs12409995; rs1684949; rs6701166; rs12139114; rs12562224; rs2706180; rs524814; rs2783658; rs11807473; rs10873868; rs4611076; rs12562338; rs418644; rs12058462; rs1335864; rs4147008; rs426664; rs315045; rs17672913; rs17098502; rs17098842; rs11162133; rs2631787; rs7551529; rs12024701; rs6674758; rs17671689; rs431752; rs389899; rs9437435; rs12075208; rs7552671; rs387214; rs4949713; rs17660966; rs6699305; rs6666452; rs17098322; rs7534037; rs11587725; rs2117903; rs2043600; rs188789; rs12080978; rs6669101; rs2307960; rs4245651; rs1436086; rs11588841; rs11809667; rs12038570; rs11162107; rs12130104; rs6672569; rs7516276; rs12123443; rs17098606; rs315053; rs11586775; rs12035993; rs17098469; rs289675; rs11805226; rs17672606; rs12123510; rs1359470; rs12410374; rs3883995; rs17099107; rs11583947; rs10782616; rs17098793; rs1932260; rs4587607; rs17098543; rs1251578; rs7529007; rs7541592; rs236019; rs3887563; rs315075; rs12131613; rs17662194; rs17684417; rs527974; rs11585263; rs17098221; rs1498371; rs9645420; rs289699; rs2631780; rs381749; rs587021; rs551877; rs11162141; rs12755198; rs12407845; rs12032409; rs11162115; rs11162140; rs12727514; rs17609927; rs11583963; rs12091356; rs17098937; rs7539882; rs12728129; rs2706198; rs17098119; rs17098145; rs12140509; rs417738; rs12402760; rs7534076; rs17098442; rs12742787; rs17098319; rs6657805; rs2210831; rs7518618; rs7414129; rs315015; rs680442; rs412361; rs1890968; rs1359466; rs17098830; rs11806331; rs12128567; rs12089425; rs4590722; rs4593881; rs11162145; rs9437138; rs10782612; rs12138879; rs12036155; rs11162082; rs2307961; rs447383; rs2209459; rs11162097; rs2631778; rs1251573; rs6685923; rs17098071; rs12097317; rs12057859; rs315038; rs7531378; rs2392032; rs17098859; rs2392037; rs6699906; rs12127441; rs4304640; rs12410961; rs11802315; rs6671888; rs3011992; rs17098734; rs12141224; rs17627490; rs289676; rs12062929; rs17099201; rs12734926; rs12749279; rs12144641; rs7534207; rs6665167; rs17099101; rs17098434; rs17098538; rs17660501; rs10873882; rs188788; rs1609619; rs12063835; rs12129945; rs2164440; rs17099115; rs17099097; rs448003; rs17098183; rs425877; rs901490; rs191142; rs2631785; rs6593528; rs4245648; rs12078367; rs7532337; rs393933; rs4642944; rs4604739; rs7534087; rs11810412; rs1335739; rs1498372; rs9645421; rs2706183; rs4949704; rs9437136; rs6691694; rs10873871; rs11162166; rs17668087; rs12097226; rs17098471; rs447118; rs10782610; rs9437421; rs12406797; rs6658210; rs1436083; rs7528474; rs2065793; rs945365; rs1325295; rs17098239; rs7515337; rs315024; rs9437429; rs12136894; rs3904688; rs11162163; rs1123962; rs384233; rs7536107; rs549899; rs315071; rs11577449; rs17684029; rs315047; rs7526216; rs289689; rs1251574; rs12084205; rs2631794; rs17668894; rs289688; rs11581772; rs315085; rs6593540; rs7519489; rs6666049; rs17098844; rs315016; rs17629475; rs2577803; rs541675; rs12760714; rs12057667; rs12749057; rs11162131; rs12070061; rs12753434; rs170261; rs291060; rs510025; rs12067933; rs6658488; rs12071740; rs289691; rs17098968; rs12737993; rs12744209; rs2706194; rs6593529; rs1972250; rs537620; rs2392031; rs17098784; rs9645423; rs3011991; rs17098328; rs1325293; rs12083141; rs4949703; rs7519817; rs315008; rs3908823; rs7519711; rs1146661; rs4590721; rs12563461; rs17669251; rs3862902; rs11586719; rs12133113; rs11162110; rs4474306; rs6664579; rs11162079; rs34983951; rs41291526; rs41291528; rs41291532; rs1051414; rs41291524; rs41291530; rs6677337; rs433842; rs11162080; rs12565106; rs5775322; rs10218628; rs2706182; rs6665907; rs35416159; rs3079477; rs12043272; rs12239934; rs35738454; rs35477179; rs5775352; rs12120578; rs34730098; rs34556993; rs12043751; rs450636; rs28579443; rs34418089; rs12141551; rs35043586; rs9437425; rs35279421; rs34411363; rs35975773; rs34413940; rs34926846; rs560934; rs12082216; rs5775328; rs34921779; rs34725000; rs2706200; rs34121784; rs4528160; rs11345472; rs2882075; rs35731973; rs12121325; rs504902; rs35098381; rs9645424; rs34043365; rs35102341; rs35952040; rs4949709; rs11162108; rs34074311; rs34213967; rs12090224; rs500495; rs12039723; rs2631790; rs495796; rs11461241; rs35857669; rs34465829; rs35146276; rs34187494; rs7415638; rs35327017; rs34853283; rs35260098; rs4554766; rs35503834; rs12143753; rs35297377; rs315061; rs366497; rs4309028; rs34952974; rs9437410; rs34059069; rs315059; rs7534314; rs35213516; rs10713405; rs34852387; rs17098047; rs35323839; rs12046169; rs35320092; rs35435410; rs34809024; rs11586004; rs35702182; rs188333; rs35005164; rs35217803; rs28618101; rs13374436; rs35590212; rs10665444; rs2349045; rs33986133; rs13373782; rs35649641; rs12142194; rs35398262; rs11162177; rs5775348; rs12058399; rs28590453; rs481884; rs7536202; rs34940726; rs7414390; rs34530096; rs34432728; rs35337731; rs1325288; rs11406854; rs41291518; rs12039793; rs1909187; rs35713545; rs12127832; rs1985291; rs1146667; rs443069; rs4285751; rs17098080; rs35444834; rs35098788; rs12091352; rs34161278; rs34744045; rs192875; rs34032441; rs444246; rs35275750; rs35250020; rs35271374; rs12030342; rs417373; rs12037956; rs34140871; rs315052; rs12141583; rs34015447; rs7535764; rs12729622; rs36060153; rs34783531; rs28514588; rs12753062; rs12142863; rs442951; rs34163829; rs28602837; rs453928; rs34963969; rs2065794; rs35619666; rs34555371; rs12145151; rs11359719; rs6672922; rs35938981; rs34826999; rs34929685; rs34912507; rs28408528; rs3079481; rs12745204; rs2043601; rs10529440; rs35901241; rs35476496; rs528567; rs34417115; rs12046100; rs6686980; rs7534199; rs35157329; rs11162153; rs12402297; rs35398248; rs34512837; rs192628; rs34439995; rs479548; rs34192349; rs431366; rs35623412; rs34269658; rs12140229; rs4492668; rs3904690; rs12738457; rs28485639; rs34812521; rs34929069; rs34310820; rs34385697; rs34560327; rs315086; rs34219659; rs12125749; rs5775332; rs34409259; rs12568036; rs3011987; rs35497641; rs4949712; rs34288340; rs35661332; rs12118942; rs35433294; rs2631786; rs11162123; rs12066065; rs427172; rs12118851; rs35370534; rs36073334; rs12022160; rs34485263; rs34274356; rs35359352; rs34522118; rs35761127; rs34929386; rs12407026; rs315069; rs35739331; rs11337512; rs503193; rs35510355; rs7528467; rs35447434; rs36120780; rs2706187; rs11410196; rs549496; rs35722541; rs35538820; rs17098501; rs12730219; rs12727362; rs315072; rs35533769; rs35522518; rs11162106; rs34707336; rs11581032; rs12031140; rs188303; rs35412027; rs182612; rs36008410; rs12088394; rs11389640; rs34750802; rs10628014; rs35932012; rs315074; rs10581262; rs35536470; rs315054; rs2706201; rs12731300; rs35036475; rs12120710; rs35218002; rs9437129; rs504901; rs454801; rs35300379; rs12021536; rs34734308; rs35312320; rs36221602; rs35176284; rs34963917; rs36073183; rs12022595; rs5775323; rs36066755; rs34260756; rs451421; rs12139305; rs289680; rs34944384; rs35505105; rs35470456; rs35556653; rs435687; rs35105825; rs11430411; rs35802431; rs35790016; rs34866377; rs11162156; rs34679957; rs35521128; rs411336; rs34022589; rs6657828; rs34282090; rs34508435; rs12036720; rs12750897; rs12036013; rs12732281; rs12023528; rs970646; rs556772; rs1146666; rs1886653; rs34612526; rs1124505; rs35361826; rs34879076; rs11413126; rs2706186; rs35156708; rs2631783; rs5775345; rs12758101; rs35496403; rs412490; rs34411005; rs4409708; rs12408344; rs34625882; rs12140759; rs12143990; rs2706197; rs423742; rs4263950; rs35310450; rs7545904; rs28477418; rs11324889; rs35003613; rs34733113; rs12065647; rs4382666; rs176531; rs35379318; rs12142830; rs35088605; rs2783660; rs35033624; rs5775351; rs35440553; rs178355; rs34801394; rs10660490; rs501401; rs10671684; rs7530506; rs35440524; rs2117904; rs10659712; rs4307606; rs35184896; rs35974751; rs12745663; rs12753211; rs12039983; rs10615636; rs12043057; rs9645422; rs5775344; rs34400659; rs12073986; rs6687690; rs35938722; rs34030615; rs12734664; rs291066; rs9437145; rs9437154; rs1486930; rs28667832; rs12040351; rs35498723; rs34319161; rs34011421; rs35754395; rs10443175; rs17626151; rs12731299; rs34926311; rs3079480; rs2783382; rs35592911; rs448156; rs35977854; rs34019487; rs10526487; rs35472781; rs35908014; rs7411268; rs34092895; rs13376512; rs4617456; rs17098249; rs1892479; rs34933271; rs560937; rs428103; rs619059; rs439492; rs10747348; rs34810241; rs505960; rs315092; rs35515372; rs11162085; rs35258685; rs11581791; rs1570826; rs35983422; rs34551527; rs12129965; rs41291522; rs34612581; rs11303222; rs35523814; rs34587883; rs35866506; rs28439552; rs9437391; rs12069342; rs6659584; rs167048; rs12084698; rs34410935; rs35768506; rs11443765; rs34189218; rs11331532; rs430875; rs34879302; rs35260827; rs6674753; rs11444517; rs34859398; rs28654262; rs5775331; rs33999183; rs35038225; rs11270928; rs12063135; rs34044569; rs4644537; rs35298544; rs34049372; rs4949699; rs28647864; rs36115631; rs448832; rs35814211; rs11277074; rs315058; rs4288644; rs3086266; rs34754789; rs17098144; rs12725077; rs12742374; rs34103096; rs5775349; rs2065780; rs33968675; rs1093560; rs505999; rs764010; rs34878969; rs35047124; rs4949714; rs35559264; rs35989413; rs12023292; rs34135726; rs12086586; rs2783659; rs36133961; rs34480345; rs12402058; rs34170584; rs36116523; rs10660996; rs4644536; rs10669485; rs34995712; rs10540616; rs35536996; rs11337041; rs35878562; rs2631784; rs12141557; rs12024251; rs411398; rs2783987; rs5775336; rs35907427; rs12065523; rs34741962; rs7412574; rs12144132; rs12731195; rs10873884; rs35260316; rs34793833; rs1335741; rs34179679; rs28691688; rs12089339; rs11162175; rs12134233; rs555351; rs5775329; rs11802363; rs41291520; rs35222248; rs35218078; rs11162126; rs12145584; rs12082020; rs35533622; rs10639221; rs12127822; rs35570954; rs12748617; rs2992635; rs1335744; rs523756; rs11345917; rs12134351; rs409312; rs34577853; rs12080772; rs12043522; rs34057839; rs35306096; rs34785262; rs35877463; rs35829197; rs34464699; rs4949721; rs2706199; rs11373156; rs12732074; rs11349237; rs6684693; rs2631797; rs34507630; rs454885; rs34167247; rs28627540; rs637165; rs36050099; rs35675367; rs386113; rs34666962; rs12754694; rs2631792; rs35383500; rs34532291; rs2706184; rs34290009; rs35521113; rs419320; rs475686; rs28506791; rs12029263; rs12739512; rs2101402; rs9437407; rs35948115; rs35553353; rs35714649; rs41509344; rs12753058; rs11340708; rs28756056; rs9437139; rs35529117; rs28408134; rs3042284; rs1909186; rs35160558; rs34712414; rs6674682; rs34308040; rs12752451; rs5775334; rs11392930; rs4949621; rs6665773; rs12125168; rs12730384; rs34586014; rs394839; rs34363179; rs35690030; rs35523568; rs35423128; rs2931460; rs35923060; rs34271295; rs1347540; rs35161809; rs6657466; rs315070; rs5775346; rs35846186; rs2577804; rs12756146; rs12092535; rs35105465; rs34393802; rs34195834; rs34423456; rs6690498; rs12759317; rs4399205; rs534614; rs4414090; rs28575187; rs398826; rs34648991; rs34618803; rs2631788; rs2706185; rs12144245; rs567250; rs532583; rs656038; rs2706203; rs12077470; rs315056; rs12037958; rs34587352; rs12047574; rs5775324; rs34310305; rs35336712; rs11588365; rs4129849; rs34482701; rs35051976; rs12049009; rs35012976; rs7527852; rs34419836; rs1892478; rs1932261; rs12745486; rs10528375; rs12137522; rs34396231; rs12757276; rs35059666; rs11449269; rs3086280; rs17098141; rs6699620; rs34010819; rs7521666; rs2783986; rs11582275; rs34637312; rs34570106; rs5775354; rs4086568; rs34529918; rs35511961; rs11584719; rs12754895; rs12033631; rs35143170; rs4000173; rs5775355; rs34013759; rs12039952; rs12096910; rs11379626; rs6702596; rs427425; rs28450617; rs35851161; rs420732; rs7550026; rs3904689; rs1733824; rs35879075; rs36005022; rs35242060; rs34437349; rs7520183; rs35232969; rs35356464; rs12031106; rs315050; rs36017719; rs34879675; rs11162151; rs2209460; rs12130011; rs11162173; rs35886720; rs407010; rs1335743; rs2210830; rs34998318; rs34260402; rs415189; rs12401601; rs35437376; rs13375497; rs546532; rs4949635; rs446061; rs35300914; rs12126170; rs5775335; rs33941910; rs28660243; rs11454801; rs4245649; rs34514956; rs370908; rs34377116; rs12068141; rs11806882; rs5005185; rs1985292; rs35240003; rs35349269; rs34865436; rs35694989; rs34567994; rs34110793; rs3915925; rs453606; rs531588; rs12407327; rs35507477; rs9437151; rs11389393; rs12069514; rs2783662; rs12059995; rs35140220; rs439966; rs3079560; rs6669109; rs4576695; rs6665744; rs393296; rs389889; rs12041579; rs2706191; rs5775347; rs12732285; rs34006266; rs35087821; rs664935; rs11330040; rs35527607; rs12031661; rs452952; rs407606; rs35578176; rs34575654; rs35385527; rs5775350; rs35035784; rs35339464; rs4034974; rs34901990; rs5775327; rs536811; rs4450061; rs6673952; rs11267387; rs34642574; rs12734748; rs34504826; rs3045867; rs35824782; rs35789244; rs7524014; rs6671876; rs35495132; rs7413050; rs36017935; rs35632611; rs449350; rs28394872; rs443803; rs35562335; rs11298028; rs2706190; rs35317596; rs11404471; rs34277706; rs34277365; rs672294; rs4949720; rs35071989; rs12760543; rs17098700; rs473421; rs35603384; rs35233415; rs12145585; rs7411266; rs10601686; rs12071138; rs34200932; rs34998321; rs11326234; rs11585993; rs12098090; rs34502453; rs34366137; rs12732283; rs6593536; rs11582847; rs28615770; rs5775340; rs12401777; rs35269662; rs12045874; rs437394; rs35271559; rs12734753; rs1570824; rs428272; rs12058643; rs6695705; rs11445074; rs34936433; rs365008; rs34826881; rs35351812; rs12066200; rs35270322; rs34765335; rs12139215; rs12042920; rs2706188; rs1436082; rs429626; rs33967566; rs2706204; rs5011133; rs12753519; rs33923670; rs221522; rs12408722; rs6659588; rs11426822; rs36029364; rs5775333; rs35148588; rs35091800; rs12119200; rs34028285; rs11585745; rs12745895; rs5775326; rs315064; rs34475625; rs11316194; rs34993889; rs34117095; rs2392035; rs35480385; rs35958635; rs34887688; rs12043809; rs7526081; rs35323311; rs35673997; rs17098350; rs35898987; rs34589563; rs523845; rs12048250; rs1251812; rs35150035; rs35832438; rs28545064; rs35270212; rs34927225; rs35554844; rs12093486; rs36034812; rs34573571; rs10635688; rs12022733; rs9437450; rs35652544; rs34992360; rs6666898; rs6661915; rs12028633; rs35941147; rs11585336; rs450708; rs34215195; rs12034205; rs35377022; rs12734600; rs5775342; rs12759169; rs172333; rs12137841; rs405932; rs9645419; rs12057631; rs428087; rs35228810; rs12565877; rs3904691; rs12732933; rs12748281; rs10646330; rs2706189; rs34130960; rs28651305; rs5775339; rs11162122; rs315055; rs5775353; rs392062; rs289681; rs12137521; rs3963296; rs4418663; rs12089135; rs1684947; rs6671258; rs480082; rs34427182; rs442595; rs1855826; rs11582274; rs10782615; rs12118231; rs35401807; rs12239258; rs35068994; rs10518531; rs10873894; rs1146657; rs1146658; rs1146659; rs11800149; rs12041808; rs12058276; rs12072113; rs12073623; rs12404254; rs12404937; rs12407931; rs12409374; rs1251465; rs1251466; rs1251467; rs1251468; rs1251470; rs1251471; rs1251472; rs1251473; rs1251474; rs12568806; rs12728414; rs13375817; rs1591911; rs17098034; rs171017; rs17633724; rs17633814; rs17684771; rs17684978; rs17685020; rs2031483; rs2225785; rs2349044; rs291073; rs291074; rs291075; rs341016; rs341017; rs341018; rs34354538; rs3748712; rs484299; rs564853; rs601818; rs608880; rs621590; rs636038; rs658035; rs661628; rs663893; rs6676041; rs6691267; rs674836; rs683148; rs687569; rs699830; rs7535776; rs7539040; rs7545733

# Metabolic_Enzyme_22_General_References:
12975309

# Metabolic_Enzyme_22_References:
Not Available

# Metabolic_Enzyme_23_ID:
8555

# Metabolic_Enzyme_23_Name:
Adenylate kinase 5

# Metabolic_Enzyme_23_Synonyms:
Not Available

# Metabolic_Enzyme_23_Gene_Name:
AK5

# Metabolic_Enzyme_23_Protein_Sequence:
>Adenylate kinase 5
MCSKPEDPVEYLESCLQKVKELGGCDKVKWDTFVSQEKKTLPPLNGGQSRRSFLRNVMPE
NSNFPYRRYDRLPPIHQFSIESDTDLSETAELIEEYEVFDPTRPRPKIILVIGGPGSGKG
TQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSPIAKIITTGELAPQETTITEIKQKL
MQIPDEEGIVIDGFPRDVAQALSFEDQICTPDLVVFLACANQRLKERLLKRAEQQGRPDD
NVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDISMAVDNKLFPNKEAA
AGSSDLDPSMILDTGEIIDTGYDYEDQGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGTG
SGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKE
AMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLP
VDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAIDSIIF

# Metabolic_Enzyme_23_Number_of_Residues:
537

# Metabolic_Enzyme_23_Molecular_Weight:
60493

# Metabolic_Enzyme_23_Theoretical_pI:
4.70

# Metabolic_Enzyme_23_GO_Classification:
>>>
 Function:  phosphotransferase activity, phosphate group as acceptor
Function:  adenylate kinase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleotide kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
 Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleoside triphosphate metabolism
Process:  purine ribonucleoside triphosphate metabolism
Process:  ATP metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
 Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_23_General_Function:
Nucleotide transport and metabolism

# Metabolic_Enzyme_23_Specific_Function:
ATP + AMP = 2 ADP

# Metabolic_Enzyme_23_Pathway:
Not Available

# Metabolic_Enzyme_23_Reaction:
Not Available

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF00406:ADK

# Metabolic_Enzyme_23_Signals:
Not Available

# Metabolic_Enzyme_23_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 2.7.4.3

# Metabolic_Enzyme_23_GenBank_ID_Protein:
54311157

# Metabolic_Enzyme_23_SwissProt_ID:
Q5U622_HUMAN (Q5U622)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
AK5

# Metabolic_Enzyme_23_Geneatlas_id:
AK5

# Metabolic_Enzyme_23_hgnc_id:
HGNC:365

# Metabolic_Enzyme_23_PDB_ID:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_23_Gene_Sequence:
>1614 bp
ATGTGTTCTAAGCCCGAAGATCCAGTAGAATACTTGGAAAGTTGTTTACAAAAAGTAAAG
GAACTGGGTGGCTGTGACAAGGTGAAATGGGATACATTTGTAAGCCAGGAAAAGAAGACC
TTACCTCCACTAAATGGAGGACAGTCACGGAGATCCTTTCTAAGAAATGTAATGCCTGAA
AACTCAAACTTTCCATATCGGCGGTATGACCGGCTCCCTCCAATCCATCAATTCTCCATA
GAAAGTGACACGGATCTCTCTGAGACTGCAGAGTTGATTGAGGAGTATGAGGTTTTTGAT
CCTACCAGACCTCGACCAAAAATCATTCTTGTTATAGGTGGTCCAGGAAGTGGAAAGGGT
ACTCAGAGTTTGAAAATTGCAGAACGATATGGATTCCAATACATTTCTGTGGGAGAATTA
TTAAGAAAGAAGATCCACAGTACCAGCAGCAATAGGAAATGGAGTCCTATTGCCAAGATA
ATTACAACTGGAGAATTGGCCCCACAGGAAACAACAATTACAGAGATAAAACAAAAATTG
ATGCAAATACCTGATGAAGAGGGCATTGTTATTGATGGATTTCCAAGAGATGTTGCCCAG
GCTCTATCTTTTGAGGACCAAATCTGTACCCCCGATTTGGTGGTATTCCTGGCTTGTGCT
AATCAGAGACTCAAAGAAAGATTACTGAAGCGTGCAGAACAGCAGGGCCGACCAGACGAC
AATGTAAAAGCTACCCAAAGGAGACTAATGAACTTCAAGCAGAATGCTGCTCCATTGGTT
AAATACTTCCAGGAAAAGGGGCTCATCATGACATTTGATGCCGACCGCGATGAGGATGAG
GTGTTCTATGACATCAGCATGGCAGTTGACAACAAGTTATTTCCAAACAAAGAGGCTGCA
GCAGGTTCAAGTGACCTTGATCCTTCGATGATATTGGACACTGGAGAGATCATTGATACA
GGATATGATTATGAAGATCAGGGTGATGACCAGTTAAATGTATTTGGAGAGGACACTATG
GGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTACTGGC
TCTGGCAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCA
ACTGGCGAGCTCCTGCGTGAGGAACTGGCATCAGAATCTGAAAGAAGCAAATTGATCAGA
GACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAAGGAG
GCCATGGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAG
GTGAAGCAAGGGGAAGAGTTCGGACGCAGGATTGGAGACCCACAGTTGGTGATCTGTATG
GACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCTGCCT
GTGGACGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATC
CCCGTGATCGCCTACTACGAGACAAAAACACAGCTACACAAGATAAATGCAGAGGGAACA
CCAGAGGACGTTTTTCTTCAACTCTGCACAGCTATTGACTCTATTATTTTCTGA

# Metabolic_Enzyme_23_GenBank_ID_Gene:
BC033896

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_23_Locus:
1p31

# Metabolic_Enzyme_23_SNPs:
rs2803140; rs1167206; rs2815311; rs3509; rs10873950; rs2602946; rs4949811; rs2689680; rs6683829; rs10747353; rs1779173; rs7517796; rs2602945; rs1619903; rs4949788; rs12133976; rs6665543; rs6669724; rs2602944; rs7517698; rs7531431; rs2602943; rs6680763; rs3767031; rs4949660; rs7517717; rs3767030; rs7534033; rs11162308; rs2815313; rs2815324; rs1167214; rs1010195; rs1167202; rs2054020; rs1670617; rs2803152; rs2088518; rs1721163; rs2647486; rs1167205; rs2647497; rs1453982; rs2602936; rs2815319; rs1010196; rs1874817; rs2815325; rs2602934; rs1167201; rs1721165; rs1874819; rs2029768; rs1463324; rs2689683; rs1167212; rs1721166; rs936001; rs2602951; rs1909202; rs1377733; rs2647503; rs6672375; rs4949803; rs2251456; rs6696968; rs1874818; rs2803166; rs4949658; rs6681717; rs1377731; rs7547493; rs6680677; rs6675743; rs11808966; rs1721164; rs6603950; rs2815326; rs9324162; rs1498404; rs4949808; rs11162357; rs6667803; rs7545638; rs11162331; rs7514041; rs3911295; rs11162355; rs1167207; rs12564604; rs10873933; rs1823837; rs2815337; rs11162332; rs7517051; rs12049202; rs3844165; rs6684022; rs6658302; rs12079234; rs1993266; rs10873937; rs7524866; rs6663047; rs2803155; rs2803169; rs7514937; rs12044354; rs2054017; rs4949659; rs11162309; rs12040471; rs7537472; rs7518696; rs10873947; rs2815310; rs10493603; rs10873935; rs7545544; rs7512893; rs9324161; rs10782645; rs11162323; rs12567557; rs7531286; rs9787153; rs12565526; rs4949792; rs11162340; rs6662853; rs6691415; rs11162330; rs3844166; rs7546131; rs12079206; rs11162311; rs2647491; rs7522356; rs2647510; rs2815314; rs6696083; rs11162356; rs2247536; rs11810135; rs12074409; rs2034708; rs1532508; rs10747354; rs2803136; rs4949809; rs6704141; rs11162333; rs4949794; rs4245658; rs4033036; rs12076479; rs2803168; rs1616948; rs10782651; rs7515509; rs10782648; rs10873938; rs7537574; rs6703133; rs1823838; rs7542588; rs17100513; rs12142918; rs4351702; rs17100319; rs6668429; rs2351034; rs12130313; rs7534707; rs17100436; rs2689676; rs17100231; rs9633480; rs4949793; rs10873941; rs17100521; rs9633479; rs11162351; rs1779177; rs12136415; rs2349966; rs12568374; rs1498405; rs17100224; rs2647519; rs1670612; rs11806344; rs17100305; rs17100509; rs12132273; rs3767036; rs11584919; rs2815307; rs1603743; rs2799555; rs6673059; rs11162341; rs12125503; rs1167196; rs10493536; rs2882289; rs2198511; rs7546963; rs12140227; rs12093263; rs12141929; rs7514177; rs11583090; rs3112826; rs7529652; rs11585310; rs2803147; rs2799562; rs3896705; rs10518553; rs1498402; rs4949655; rs9439799; rs6695572; rs6603948; rs11162347; rs10873945; rs7512897; rs12568528; rs1616272; rs2647508; rs2133203; rs17379910; rs1377736; rs3112830; rs7551211; rs4600093; rs11162319; rs1453974; rs11806197; rs6695989; rs2349965; rs11162312; rs10518551; rs1532509; rs1565850; rs3738079; rs11588898; rs2815323; rs11162334; rs17100274; rs1874816; rs2647499; rs4033035; rs17098286; rs11585455; rs6698295; rs1167215; rs1670618; rs12069838; rs1377732; rs12030598; rs1167217; rs10493605; rs1377734; rs12095801; rs11162350; rs7549462; rs12037071; rs2256679; rs11590456; rs10493606; rs11809786; rs2799553; rs17380592; rs1869467; rs4949802; rs6667519; rs6661765; rs12407481; rs7521772; rs7536307; rs17100646; rs2799561; rs2247742; rs2602927; rs1670611; rs12564592; rs1565851; rs2246124; rs6702968; rs6697255; rs12724560; rs2803153; rs7536433; rs2172727; rs7537603; rs1840246; rs17100317; rs4033037; rs6685087; rs12404204; rs6675781; rs12070870; rs6689581; rs10782647; rs3911801; rs12568376; rs7531411; rs17380852; rs17100308; rs1551331; rs12569104; rs5018314; rs1353727; rs3767033; rs4949800; rs4949799; rs12124822; rs17380036; rs10493602; rs10873934; rs11162352; rs10873944; rs1779178; rs3767035; rs4949654; rs9324160; rs1498400; rs17100499; rs17098287; rs7536818; rs11162326; rs2602948; rs2602953; rs12022440; rs9787060; rs12123060; rs4949789; rs3896706; rs17100674; rs1498403; rs17380796; rs7528932; rs6659899; rs17100570; rs10782646; rs10493604; rs12402184; rs6703688; rs1498399; rs17100524; rs2133204; rs3767032; rs12760589; rs12079316; rs6687876; rs7554922; rs3121778; rs12030302; rs11162336; rs12565558; rs11583735; rs11807111; rs12079185; rs17100458; rs17378915; rs2245189; rs7519901; rs11800652; rs1498401; rs7367731; rs17384946; rs2647515; rs6603949; rs1498407; rs4491097; rs11162310; rs12062661; rs2602937; rs12080101; rs3767034; rs1869468; rs17100204; rs12071212; rs17100218; rs11162335; rs2647525; rs17100475; rs12133318; rs17098226; rs1167216; rs17380544; rs10735750; rs12030818; rs7516637; rs11162364; rs936004; rs12068040; rs1823840; rs11162324; rs17100654; rs2602932; rs6704312; rs12754926; rs6603951; rs1353726; rs7517486; rs1869466; rs2803144; rs2803164; rs4949798; rs12048207; rs7537639; rs12031867; rs10873936; rs17100731; rs4431892; rs12073309; rs12128049; rs2689684; rs12733666; rs11162348; rs2803149; rs3962875; rs1167200; rs7532748; rs4949656; rs4949791; rs12131772; rs12726963; rs6674790; rs17100672; rs2349964; rs2647523; rs11162362; rs2799550; rs2647487; rs17100422; rs12404374; rs7527150; rs12073962; rs6680888; rs2647517; rs1779175; rs3862893; rs12741939; rs2815335; rs6680716; rs11162339; rs7516300; rs4949807; rs10127564; rs2054019; rs17100172; rs17100677; rs11590086; rs2602940; rs12144794; rs1377737; rs7551729; rs12066994; rs17100185; rs12736701; rs1532511; rs17100655; rs9439800; rs10782654; rs12730089; rs2602942; rs6603940; rs12060669; rs3113637; rs12037848; rs11162327; rs2815305; rs7415865; rs2799554; rs12092582; rs2647512; rs7529083; rs2803139; rs4949797; rs2803162; rs6673604; rs12404342; rs1167198; rs2647522; rs11162337; rs2647484; rs12740982; rs2803157; rs11811611; rs7519476; rs7546116; rs12401953; rs12034899; rs1615404; rs2351032; rs4949805; rs2256735; rs1670616; rs17380099; rs1167209; rs7550626; rs2647520; rs12045755; rs11585860; rs2803160; rs1721167; rs2815309; rs4589153; rs4949653; rs2123799; rs1167213; rs6603943; rs2602949; rs2647514; rs1909203; rs12080110; rs4245657; rs11162363; rs11162329; rs7524147; rs10873949; rs12033923; rs12409322; rs12062754; rs11162358; rs2351033; rs12070567; rs2815331; rs12047928; rs1010061; rs9633478; rs2647504; rs17100377; rs7532803; rs17100440; rs6603941; rs11162342; rs17100692; rs2647493; rs2133202; rs7512141; rs1966873; rs12730972; rs17100476; rs2221084; rs2647498; rs12046197; rs17385141; rs12135843; rs2647526; rs17100241; rs12077615; rs12567785; rs2799551; rs17100198; rs17100556; rs12065923; rs4402168; rs12093881; rs1532507; rs12731886; rs17379082; rs2602931; rs2647516; rs3104461; rs2815317; rs2815306; rs17100694; rs11162317; rs6694630; rs13376422; rs2815327; rs17371324; rs10873939; rs2154090; rs6603952; rs10873942; rs4949790; rs17100478; rs17100364; rs12745549; rs17100425; rs12085340; rs12122210; rs1167210; rs6603953; rs1377738; rs17100530; rs17100456; rs7545096; rs12751064; rs12042177; rs2815320; rs12097089; rs12030606; rs2803163; rs1909204; rs11583934; rs2803156; rs2054018; rs2647494; rs1670609; rs2647521; rs3104467; rs2815334; rs1976334; rs10873930; rs2996486; rs17100463; rs2799563; rs6671137; rs6698996; rs2167994; rs1377735; rs1779181; rs7546409; rs4949806; rs11162338; rs2799552; rs11162313; rs1670605; rs2803148; rs12729914; rs12404245; rs2602941; rs12751884; rs10873946; rs7543460; rs11162318; rs2803161; rs12095064; rs1453981; rs11162325; rs2647496; rs2647485; rs2647513; rs2815312; rs12031094; rs17100429; rs6692369; rs1167204; rs17695152; rs17100304; rs2647506; rs1167197; rs10873932; rs2799560; rs2803150; rs1013399; rs6693999; rs7528552; rs4949804; rs7511768; rs1851736; rs2004962; rs2799568; rs6697938; rs12126361; rs3835545; rs12028798; rs41292256; rs35474678; rs35528982; rs10577779; rs34360007; rs28476720; rs3835546; rs28605112; rs12184282; rs34108682; rs2647490; rs34641015; rs41292264; rs5775404; rs35194423; rs3077577; rs28701620; rs34309381; rs5775392; rs4539179; rs3113636; rs3032910; rs5024339; rs34342162; rs10618389; rs35528361; rs12239674; rs34939965; rs6699414; rs35045554; rs34509475; rs12752648; rs12747320; rs2803171; rs10610715; rs12737543; rs12753797; rs10643921; rs34198954; rs35490046; rs4491099; rs4567326; rs2133205; rs2803146; rs33950044; rs2803137; rs36066707; rs41292268; rs34561659; rs12747609; rs12130867; rs34444999; rs10581719; rs5775400; rs35473006; rs34632021; rs35962579; rs34563024; rs28482266; rs1670614; rs35364802; rs34520920; rs11585233; rs34026852; rs34899933; rs34781584; rs34093068; rs11351073; rs2799558; rs35905985; rs3112828; rs36121999; rs11275907; rs5775406; rs35340213; rs12089562; rs1470898; rs34216425; rs35100611; rs6603942; rs2647492; rs12737982; rs3113639; rs35597576; rs6660312; rs34812657; rs5775394; rs3911296; rs11306378; rs12754946; rs5775386; rs12741407; rs6659799; rs6663792; rs34544896; rs35047787; rs10672519; rs34500185; rs35425557; rs34578405; rs11384873; rs11331001; rs2647502; rs41292266; rs34019719; rs2815328; rs12754430; rs34579463; rs4033046; rs2882564; rs4033034; rs1779180; rs12738950; rs12089711; rs35137146; rs34732222; rs1973057; rs35367032; rs34776258; rs4546964; rs3892546; rs1936437; rs3122396; rs2803154; rs35752791; rs11310843; rs34997978; rs11162328; rs10658959; rs5775396; rs1840247; rs34814131; rs34219620; rs41306633; rs9439784; rs34229344; rs12065811; rs34800536; rs12760955; rs10641799; rs12742485; rs4949801; rs5775408; rs35923030; rs35263113; rs2647488; rs1453975; rs12088702; rs7417258; rs1532510; rs3077617; rs11585641; rs34191126; rs3104462; rs12025030; rs35881426; rs2647524; rs5775388; rs35160863; rs34079169; rs3104466; rs6700151; rs2454328; rs11583478; rs12731521; rs34781573; rs28635212; rs1721168; rs12129136; rs11355323; rs35670415; rs35883964; rs41428048; rs17381128; rs12145231; rs6664497; rs5775409; rs3913229; rs12095237; rs4420134; rs28858546; rs35866723; rs34676920; rs2602929; rs36053089; rs35157453; rs34570834; rs2803142; rs28560013; rs11287373; rs5775390; rs34854145; rs2256812; rs12039708; rs35838303; rs4562674; rs6660313; rs35754175; rs1498409; rs7532905; rs1167211; rs3100632; rs11583481; rs12240043; rs35205007; rs12137455; rs17100210; rs34162977; rs35651270; rs35751413; rs10687945; rs34192042; rs34581049; rs721514; rs4317858; rs12741389; rs4033042; rs3104464; rs3121777; rs12753082; rs34374541; rs12059542; rs34624933; rs4342893; rs2803167; rs35029067; rs12079001; rs10635433; rs35612924; rs36055551; rs6670567; rs12732540; rs36024544; rs34721376; rs17100430; rs1779176; rs2803135; rs12034210; rs2647505; rs11387882; rs35916064; rs2018388; rs34276249; rs12406551; rs11162345; rs34517694; rs12731983; rs12024819; rs6657424; rs11577058; rs2602939; rs11455000; rs28878211; rs11356289; rs11585642; rs1779179; rs5775398; rs10873948; rs33942843; rs1179473; rs6668328; rs34038217; rs35032414; rs10651968; rs12746354; rs4604738; rs10589201; rs11428852; rs34783496; rs12140779; rs7411262; rs35038885; rs10625327; rs12563604; rs12743457; rs12022986; rs12732561; rs34335914; rs34567357; rs34828972; rs35304863; rs35393140; rs35973848; rs11290615; rs35239700; rs1167203; rs2799556; rs35844658; rs12756901; rs28823938; rs34391713; rs10673675; rs28608963; rs12133202; rs12071077; rs28541326; rs28395330; rs12035195; rs2803159; rs5775399; rs2803138; rs11411925; rs12757491; rs34996477; rs7520851; rs11305805; rs28890262; rs10873940; rs3112829; rs2803143; rs10700476; rs35298406; rs6699130; rs34919195; rs2799559; rs3100631; rs1453976; rs35412216; rs34463378; rs10568838; rs3104463; rs34277277; rs12057706; rs12735196; rs2088517; rs34167936; rs34565581; rs5775393; rs34710967; rs4033040; rs36008355; rs34131257; rs12070404; rs2803165; rs34141642; rs12046067; rs35729964; rs7416803; rs33994249; rs35251829; rs12068504; rs7549417; rs34395455; rs4949657; rs35480521; rs34496684; rs4351701; rs12135900; rs5775383; rs2647501; rs1936438; rs7417209; rs35272247; rs4556409; rs1498408; rs3851266; rs10586398; rs12731121; rs7417056; rs6700681; rs3077570; rs34667944; rs35282414; rs7411526; rs12043793; rs34360551; rs6670430; rs35772583; rs12126330; rs17381238; rs35427612; rs34979299; rs5775397; rs9439819; rs1177502; rs7546981; rs12137672; rs11162361; rs9661264; rs5775407; rs2647489; rs1183243; rs34506812; rs34623145; rs35352712; rs12172739; rs12404451; rs34996626; rs12132133; rs12034334; rs3921995; rs3077541; rs34619075; rs35087048; rs34407415; rs2815333; rs34865607; rs1823839; rs12756133; rs28483962; rs2647518; rs12041666; rs12737014; rs5775387; rs11380102; rs12753538; rs4033045; rs34103321; rs36089522; rs34975081; rs10712325; rs34855794; rs5024338; rs2602933; rs36075033; rs34140909; rs35254623; rs12125923; rs34652234; rs10587637; rs2647495; rs34326091; rs34568620; rs36051497; rs34404890; rs2123796; rs36083236; rs2803170; rs5775395; rs2803151; rs6664913; rs12752918; rs11324649; rs35305856; rs35569847; rs12738273; rs12072100; rs1670610; rs10526328; rs34679101; rs12088013; rs12139240; rs11162346; rs12748599; rs34775316; rs34657715; rs35836390; rs12568051; rs12042881; rs34907598; rs12732787; rs2803141; rs2815329; rs34425821; rs41292260; rs35060423; rs35692250; rs11364704; rs35126601; rs11350511; rs35709353; rs12566093; rs3862894; rs28631005; rs34206262; rs10547281; rs10637505; rs35587548; rs35216620; rs12144818; rs36098400; rs5775382; rs33980298; rs35783103; rs12728752; rs36087243; rs28644426; rs28369006; rs3112825; rs3113640; rs12742953; rs35463751; rs12737366; rs12041509; rs35548350; rs34365360; rs12036958; rs34291857; rs1670615; rs36057604; rs35886747; rs33929714; rs12062613; rs35328311; rs35478846; rs34396257; rs35475576; rs2088519; rs7410994; rs34155195; rs2602938; rs11162344; rs36116132; rs34186386; rs7524107; rs3122366; rs10625085; rs35690647; rs34506775; rs2815336; rs36099665; rs36120231; rs12735922; rs35335455; rs12061595; rs3113638; rs12125332; rs34783278; rs34235538; rs34221500; rs35740273; rs2123798; rs3112827; rs12069995; rs35413139; rs11440245; rs1167208; rs35185203; rs3104465; rs34818192; rs17100630; rs4638175; rs17100538; rs12078902; rs41292262; rs2647507; rs2799557; rs5775391; rs35635429; rs35462161; rs1167199; rs5775403; rs12097728; rs5775389; rs28776274; rs2454329; rs2803158; rs34422174; rs11347735; rs12747284; rs10700619; rs35500871; rs41301251; rs12239270; rs4033041; rs10524122; rs11345707; rs34298832; rs35111545; rs7416385; rs34178467; rs12130891; rs34646507; rs12030935; rs12094209; rs7413421; rs2602928; rs10647386; rs1670613; rs34698864; rs2351031; rs1869469; rs2029769; rs12066590; rs34451301; rs35009400; rs12030994; rs12136831; rs6685119; rs35260482; rs11807469; rs12135530; rs35930501; rs35487420; rs1851735; rs11580677; rs35371663; rs2272161; rs34538335; rs1027354; rs10493537; rs10493601; rs10518446; rs10735749; rs11162306; rs11162307; rs11162365; rs12062309; rs12065011; rs12076331; rs12126117; rs12132703; rs12142405; rs12759796; rs13806; rs1419247; rs17100141; rs17100143; rs17100758; rs1721160; rs17385707; rs17689089; rs1962523; rs2220835; rs2291689; rs2291690; rs2602930; rs2647511; rs35055337; rs35740293; rs4949787; rs4949812; rs4949813; rs6656443; rs6678173; rs6692366; rs728741; rs7552291

# Metabolic_Enzyme_23_General_References:
12477932

# Metabolic_Enzyme_23_References:
Not Available

# Metabolic_Enzyme_24_ID:
8561

# Metabolic_Enzyme_24_Name:
Alpha-2,8-sialyltransferase 8E

# Metabolic_Enzyme_24_Synonyms:
ST8Sia V

# Metabolic_Enzyme_24_Gene_Name:
ST8SIA5

# Metabolic_Enzyme_24_Protein_Sequence:
>Alpha2,8sialyltransferase 8
EMRYADPSPNRDLLGSRTLLFIFICAFALVTLLQQILYGRNYIKRYFEFYEGPFEYNSTR
CLELRHEILEVKVLSMVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCNAPAFLFT
TQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCG
REINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVY
ENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRI
STGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGGHAMPSEIFNFLH
LHSRGILRVHTGTCSCC

# Metabolic_Enzyme_24_Number_of_Residues:
376

# Metabolic_Enzyme_24_Molecular_Weight:
43831

# Metabolic_Enzyme_24_Theoretical_pI:
9.22

# Metabolic_Enzyme_24_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  sialyltransferase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  intrinsic to organelle membrane
Component:  intrinsic to Golgi membrane
Component:  integral to Golgi membrane

# Metabolic_Enzyme_24_General_Function:
Not Available

# Metabolic_Enzyme_24_Specific_Function:
May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively

# Metabolic_Enzyme_24_Pathway:
Not Available

# Metabolic_Enzyme_24_Reaction:
Not Available

# Metabolic_Enzyme_24_Pfam_Domain_Function:
PF00777:Glyco_transf_29

# Metabolic_Enzyme_24_Signals:
1-32

# Metabolic_Enzyme_24_Transmembrane_Regions:
18-38

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 2.4.99.-

# Metabolic_Enzyme_24_GenBank_ID_Protein:
2353694

# Metabolic_Enzyme_24_SwissProt_ID:
SIA8E_HUMAN (O15466)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
ST8SIA5

# Metabolic_Enzyme_24_Geneatlas_id:
ST8SIA5

# Metabolic_Enzyme_24_hgnc_id:
HGNC:17827

# Metabolic_Enzyme_24_PDB_ID:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Potential)

# Metabolic_Enzyme_24_Gene_Sequence:
>1131 bp
ATGCGCTACGCGGACCCCTCGCCCAACCGGGATTTGTTGGGGAGCCGAACTTTGCTCTTC
ATCTTCATCTGCGCCTTTGCCTTGGTGACCTTGCTGCAACAGATCCTGTATGGCAGGAAC
TACATTAAGAGGTACTTTGAATTTTATGAGGGCCCTTTTGAATATAACTCCACAAGATGC
CTGGAGCTGAGGCACGAAATATTGGAAGTGAAGGTGCTGTCCATGGTGAAGCAGTCAGAG
CTGTTCGACAGGTGGAAGAGCCTCCAGATGTGCAAATGGGCGATGAACATCTCTGAGGCC
AACCAGTTCAAGTCTACTCTGTCCAGGTGCTGCAACGCCCCTGCCTTTCTCTTCACCACC
CAGAAGAACACTCCCCTGGGGACAAAGCTCAAGTATGAGGTGGACACCAGTGGCATCTAC
CACATCAACCAGGAGATCTTCCGCATGTTTCCCAAGGACATGCCCTACTACCGGTCCCAG
TTTAAGAAGTGTGCTGTAGTGGGCAACGGAGGCATCTTGAAGAACAGCCGCTGCGGGAGG
GAGATCAACAGCGCCGACTTCGTCTTCCGGTGCAACCTGCCCCCCATCTCAGAGAAGTAC
ACCATGGATGTGGGGGTGAAGACGGATGTGGTCACTGTGAACCCCAGCATCATCACAGAG
AGGTTCCACAAGCTGGAGAAGTGGCGGCGGCCGTTCTATCGCGTGCTGCAGGTGTACGAG
AACGCGTCGGTGCTGCTGCCTGCCTTCTACAACACGCGCAACACCGACGTGTCCATCCGC
GTCAAGTACGTGCTGGACGACTTCGAATCGCCGCAAGCTGTCTACTACTTCCATCCGCAG
TACCTGGTCAACGTGTCGCGCTACTGGCTCAGCCTGGGGGTGCGCGCCAAGCGCATCAGC
ACCGGCCTCATTCTGGTCACTGCGGCGCTGGAGCTCTGTGAGGAGGTGCACCTCTTTGGC
TTCTGGGCCTTCCCCATGAACCCCTCGGGCCTGTACATCACTCACCACTACTATGACAAC
GTCAAGCCGCGTCCCGGCGGCCACGCCATGCCCTCTGAGATCTTCAACTTCCTGCACTTG
CACAGCCGAGGCATCCTCCGCGTGCACACGGGCACCTGCAGCTGCTGCTGA

# Metabolic_Enzyme_24_GenBank_ID_Gene:
U91641

# Metabolic_Enzyme_24_Chromosome_Location:
Chromosome:18

# Metabolic_Enzyme_24_Locus:
18q21.1

# Metabolic_Enzyme_24_SNPs:
rs16940043; rs619376; rs533027; rs328114; rs328117; rs328118; rs8093234; rs7237483; rs9675544; rs3893053; rs4890686; rs328132; rs11082552; rs3893060; rs9675666; rs11872518; rs4449041; rs12455461; rs4890338; rs9946000; rs4890336; rs12457282; rs4624284; rs948569; rs328120; rs3893181; rs4624285; rs662397; rs11082549; rs11082558; rs328131; rs2509940; rs9950834; rs8096014; rs12454493; rs16939983; rs11659388; rs11872859; rs10502877; rs633780; rs7229344; rs9956677; rs12606073; rs12457104; rs16939989; rs9304334; rs11663996; rs7237482; rs756032; rs4121686; rs328115; rs11082551; rs9955860; rs9952976; rs1075892; rs659682; rs16940040; rs11082548; rs2155987; rs948570; rs4890339; rs7237805; rs8098387; rs12455528; rs4890692; rs4121822; rs4270264; rs4574016; rs4408626; rs17700084; rs7229175; rs17707032; rs9961033; rs17779820; rs12455532; rs11662364; rs8095667; rs662191; rs12970759; rs634070; rs472371; rs650329; rs12605659; rs4890685; rs481297; rs11876971; rs532849; rs12454436; rs7231689; rs16940042; rs482351; rs3893061; rs4890684; rs647582; rs9807683; rs9949646; rs328113; rs7232509; rs12956659; rs16939971; rs577565; rs11659721; rs17779802; rs9956435; rs3886794; rs12606222; rs12956914; rs479328; rs4121688; rs4890689; rs4890683; rs3893054; rs10468985; rs328119; rs477903; rs577568; rs4402660; rs9952315; rs505408; rs12968988; rs11664294; rs12956754; rs4121687; rs9961625; rs8098541; rs570009; rs479634; rs4890682; rs9954985; rs521766; rs17778405; rs16939980; rs632814; rs8099322; rs12957855; rs4890691; rs608127; rs11873719; rs328116; rs7506386; rs9959281; rs4890337; rs9959279; rs502904; rs7229768; rs16939988; rs9675549; rs521726; rs7229343; rs328112; rs8095567; rs601291; rs16940018; rs8097980; rs4890687; rs9961836; rs12458074; rs12608055; rs17778494; rs649806; rs17778939; rs3809961; rs3809958; rs3809962; rs1941982; rs328133; rs3809959; rs10502876; rs4890335; rs2469473; rs34776857; rs34504902; rs35293759; rs35535631; rs9966652; rs1941978; rs3893058; rs35621162; rs34281307; rs33959869; rs2469901; rs11082556; rs527835; rs4324223; rs10693694; rs34073971; rs34353698; rs34766517; rs34593666; rs34722127; rs4619490; rs28528836; rs948568; rs35624372; rs5824636; rs1943671; rs36007614; rs633774; rs667402; rs7235968; rs9955817; rs34075230; rs4558488; rs10640074; rs35047631; rs10680660; rs41471844; rs1212403; rs2469900; rs36122422; rs661872; rs34702532; rs34930480; rs4890693; rs1212795; rs33969146; rs12970043; rs4461169; rs11453042; rs11334847; rs1038005; rs34697738; rs11421584; rs35683094; rs11659770; rs35619828; rs35864783; rs34679128; rs35963668; rs7229957; rs1943670; rs2943795; rs35728247; rs12968987; rs34968768; rs5824635; rs4299235; rs4553714; rs2447527; rs34947355; rs34374917; rs8083658; rs529644; rs35588909; rs5018096; rs4505432; rs34566964; rs35879974; rs12959645; rs10531565; rs34130403; rs4890690; rs33979044; rs34059964; rs34666201; rs5018097; rs34511584; rs36159538; rs35309227; rs4316846; rs7229944; rs3893056; rs8089484; rs11082554; rs9675943; rs35863629; rs4890681; rs12607312; rs35973383; rs34361051; rs4419139; rs4121689; rs4890688; rs34592961; rs35534698; rs6146301; rs614635; rs1941980; rs33927581; rs9949638; rs11082553; rs12964855; rs35587275; rs34800148; rs13381353; rs28593078; rs11082550; rs11375769; rs16939954; rs11287743; rs2155986; rs35555529; rs34163180; rs35336136; rs2927375; rs35159962; rs9948300; rs9955883; rs11495844; rs34953341; rs12969082; rs5824634; rs520881; rs3893057; rs35484898; rs9965993; rs33975456; rs4257297; rs33988552; rs28502205; rs12956886; rs4513191; rs648584; rs11268051; rs34883399; rs34968139; rs2447526; rs35206411; rs36168828; rs10522741; rs7243940; rs34471955; rs28679506; rs12953624; rs646607; rs1941979; rs8097565; rs646651; rs4998720; rs661870; rs16939979; rs35782490; rs34839667; rs9949555; rs36017799; rs514285; rs35488532; rs35287100; rs11439284; rs12970150; rs36059442; rs33937251; rs34085428; rs2365673; rs10527518; rs35864734; rs9966445; rs34318721; rs11665086; rs34762283; rs12455864; rs34825773; rs12960641; rs9965325; rs35949831; rs34782226; rs34174592; rs35271871; rs11661172; rs34009866; rs1073744; rs1073745; rs1073746; rs12456204; rs12457789; rs12962535; rs16939940; rs16960377; rs17707231; rs17707448; rs2298777; rs2298778; rs2469903; rs328134; rs371346; rs3809956; rs3809957; rs3889927; rs3893059; rs3897629; rs4121690; rs4121691; rs4287661; rs447137; rs477934; rs4890334; rs4890680; rs584648; rs645631; rs8085750; rs8087201; rs8087911; rs9945182

# Metabolic_Enzyme_24_General_References:
9199191

# Metabolic_Enzyme_24_References:
Not Available

# Metabolic_Enzyme_25_ID:
8652

# Metabolic_Enzyme_25_Name:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

# Metabolic_Enzyme_25_Synonyms:
GalNAc alpha-2,6-sialyltransferase I; ST6GalNAc I; Sialyltransferase 7A

# Metabolic_Enzyme_25_Gene_Name:
ST6GALNAC1

# Metabolic_Enzyme_25_Protein_Sequence:
>AlphaNacetylgalactosaminide alpha2,6sialyltransferase 1
MRSCLWRCRHLSQGVQWSLLLAVLVFFLFALPSFIKEPQTKPSRHQRTENIKERSLQSLA
KPKSQAPTRARRTTIYAEPVPENNALNTQTQPKAHTTGDRGKEANQAPPEEQDKVPHTAQ
RAAWKSPEKEKTMVNTLSPRGQDAGMASGRTEAQSWKSQDTKTTQGNGGQTRKLTASRTV
SEKHQGKAATTAKTLIPKSQHRMLAPTGAVSTRTRQKGVTTAVIPPKEKKPQATPPPAPF
QSPTTQRNQRLKAANFKSEPRWDFEEKYSFEIGGLQTTCPDSVKIKASKSLWLQKLFLPN
LTLFLDSRHFNQSEWDRLEHFAPPFGFMELNYSLVQKVVTRFPPVPQQQLLLASLPAGSL
RCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYGFTAFSLTQ
SLLILGNRGFKNVPLGKDVRYLHFLEGTRDYEWLEALLMNQTVMSKNLFWFRHRPQEAFR
EALHMDRYLLLHPDFLRYMKNRFLRSKTLDGAHWRIYRPTTGALLLLTALQLCDQVSAYG
FITEGHERFSDHYYDTSWKRLIFYINHDFKLEREVWKRLHDEGIIRLYQRPGPGTAKAKN


# Metabolic_Enzyme_25_Number_of_Residues:
600

# Metabolic_Enzyme_25_Molecular_Weight:
68565

# Metabolic_Enzyme_25_Theoretical_pI:
10.52

# Metabolic_Enzyme_25_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  sialyltransferase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  intrinsic to organelle membrane
Component:  intrinsic to Golgi membrane
Component:  integral to Golgi membrane

# Metabolic_Enzyme_25_General_Function:
Not Available

# Metabolic_Enzyme_25_Specific_Function:
CMP-N-acetylneuraminate + glycano-1,3-(N- acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-(2,6- alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)- glycoprotein

# Metabolic_Enzyme_25_Pathway:
map00512  O-Glycan biosynthesis

# Metabolic_Enzyme_25_Reaction:
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)- $glycoprotein

# Metabolic_Enzyme_25_Pfam_Domain_Function:
PF00777:Glyco_transf_29

# Metabolic_Enzyme_25_Signals:
1-35

# Metabolic_Enzyme_25_Transmembrane_Regions:
15-35

# Metabolic_Enzyme_25_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_25_EC_Link:
EC 2.4.99.3

# Metabolic_Enzyme_25_GenBank_ID_Protein:
7576276

# Metabolic_Enzyme_25_SwissProt_ID:
SIA7A_HUMAN (Q9NSC7)

# Metabolic_Enzyme_25_swissprot_Name:
Not Available

# Metabolic_Enzyme_25_Genecard_id:
ST6GALNAC1

# Metabolic_Enzyme_25_Geneatlas_id:
ST6GALNAC1

# Metabolic_Enzyme_25_hgnc_id:
HGNC:23614

# Metabolic_Enzyme_25_PDB_ID:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_25_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Potential)

# Metabolic_Enzyme_25_Gene_Sequence:
>1803 bp
ATGAGGTCCTGCCTGTGGAGATGCAGGCACCTGAGCCAAGGCGTCCAGTGGTCCTTGCTT
CTGGCTGTCCTGGTCTTCTTTCTCTTCGCCTTGCCCTCTTTTATTAAGGAGCCTCAAACA
AAGCCTTCCAGGCATCAACGCACAGAGAACATTAAAGAAAGGTCTCTACAGTCCCTGGCA
AAGCCTAAGTCCCAGGCACCCACAAGGGCAAGGAGGACAACCATCTATGCAGAGCCAGTG
CCAGAGAACAATGCCCTCAACACACAAACCCAGCCCAAGGCCCACACCACCGGAGACAGA
GGAAAGGAGGCCAACCAGGCACCGCCGGAGGAGCAGGACAAGGTGCCCCACACAGCACAG
AGGGCAGCATGGAAGAGCCCAGAAAAAGAGAAAACCATGGTGAACACACTGTCACCCAGA
GGGCAAGATGCAGGGATGGCCTCTGGCAGGACAGAGGCACAATCATGGAAGAGCCAGGAC
ACAAAGACGACCCAAGGAAATGGGGGCCAGACCAGGAAGCTGACGGCCTCCAGGACGGTG
TCAGAGAAGCACCAGGGCAAAGCGGCAACCACAGCCAAGACGCTCATTCCCAAAAGTCAG
CACAGAATGCTGGCTCCCACAGGAGCAGTGTCAACAAGGACGAGACAGAAAGGAGTGACC
ACAGCAGTCATCCCACCTAAGGAGAAGAAACCTCAGGCCACCCCACCCCCTGCCCCTTTC
CAGAGCCCCACGACGCAGAGAAACCAAAGACTGAAGGCCGCCAACTTCAAATCTGAGCCT
CGGTGGGATTTTGAGGAAAAATACAGCTTCGAAATAGGAGGCCTTCAGACGACTTGCCCT
GACTCTGTGAAGATCAAAGCCTCCAAGTCGCTGTGGCTCCAGAAACTCTTTCTGCCCAAC
CTCACTCTCTTCCTGGACTCCAGACACTTCAACCAGAGTGAGTGGGACCGCCTGGAACAC
TTTGCACCACCCTTTGGCTTCATGGAGCTCAACTACTCCTTGGTGCAGAAGGTCGTGACA
CGCTTCCCTCCAGTGCCCCAGCAGCAGCTGCTCCTGGCCAGCCTCCCCGCTGGGAGCCTC
CGGTGCATCACCTGTGCCGTGGTGGGCAACGGGGGCATCCTGAACAACTCCCACATGGGC
CAGGAGATAGACAGTCACGACTACGTGTTCCGATTGAGCGGAGCTCTCATTAAAGGCTAC
GAACAGGATGTGGGGACTCGGACATCCTTCTACGGCTTTACCGCCTTCTCCCTGACCCAG
TCACTCCTTATATTGGGCAATCGGGGTTTCAAGAACGTGCCTCTTGGGAAGGACGTCCGC
TACTTGCACTTCCTGGAAGGCACCCGGGACTATGAGTGGCTGGAAGCACTGCTTATGAAT
CAGACGGTGATGTCAAAAAACCTTTTCTGGTTCAGGCACAGACCCCAGGAAGCTTTTCGG
GAAGCCCTGCACATGGACAGGTACCTGTTGCTGCACCCAGACTTTCTCCGATACATGAAG
AACAGGTTTCTGAGGTCTAAGACCCTGGATGGTGCCCACTGGAGGATATACCGCCCCACC
ACTGGGGCCCTCCTGCTGCTCACTGCCCTTCAGCTCTGTGACCAGGTGAGTGCTTATGGC
TTCATCACTGAGGGCCATGAGCGCTTTTCTGATCACTACTATGATACATCATGGAAGCGG
CTGATCTTTTACATAAACCATGACTTCAAGCTGGAGAGAGAAGTCTGGAAGCGGCTACAC
GATGAAGGGATAATCCGGCTGTACCAGCGTCCTGGTCCCGGAACTGCCAAAGCCAAGAAC
TGA

# Metabolic_Enzyme_25_GenBank_ID_Gene:
Y11339

# Metabolic_Enzyme_25_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_25_Locus:
17q25.1

# Metabolic_Enzyme_25_SNPs:
rs8077382; rs35948039; rs8073763; rs28372699; rs9941380; rs8069024; rs719430; rs12450896; rs2286595; rs16969140; rs8069348; rs7221614; rs16969138; rs8067448; rs4789333; rs7218347; rs16969146; rs11658682; rs16969144; rs11651834; rs8066309; rs8067106; rs9910810; rs8065804; rs3859184; rs8072398; rs717571; rs7211678; rs4789332; rs973632; rs973631; rs2109101; rs6501911; rs2410993; rs4789331; rs16969149; rs16969151; rs9889770; rs11552091; rs17856659; rs34722280; rs28547553; rs2286594; rs8081258; rs8082427; rs8077315; rs34239838; rs8071150; rs11433733; rs34091946; rs11405259; rs36007551; rs35192005; rs10693413; rs34291112; rs11345016; rs8067449; rs35960975; rs34576387; rs9747640; rs36116508; rs36222588; rs8080520; rs34663902; rs8072546; rs34023610; rs36121806; rs34244512; rs12948173; rs10680952; rs8074415; rs9911008; rs11404475; rs8073453; rs35085606; rs10676034; rs3078365; rs11282919; rs12949793; rs11312067; rs35807484; rs12949801; rs34967189; rs7213105; rs1034930; rs10547105; rs34922423; rs35013227; rs34738375; rs34529987; rs34368134; rs35017654; rs11655186; rs34079277; rs1117059; rs1117060; rs11650467; rs11650502; rs11656386; rs12937733; rs12951774; rs2098092; rs2215288; rs2410994; rs4261576; rs4788937; rs7214860; rs7223597; rs973630; rs9903719

# Metabolic_Enzyme_25_General_References:
10536037; 12975309

# Metabolic_Enzyme_25_References:
Not Available

# Metabolic_Enzyme_26_ID:
8660

# Metabolic_Enzyme_26_Name:
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase

# Metabolic_Enzyme_26_Synonyms:
Beta-galactoside alpha-2,3-sialyltransferase; Alpha 2,3-sialyltransferase IV; Alpha 2,3-ST; Gal-NAc6S; STZ; SIAT4-C; ST3Gal III; SAT-3; ST-4

# Metabolic_Enzyme_26_Gene_Name:
ST3GAL4

# Metabolic_Enzyme_26_Protein_Sequence:
>CMPNacetylneuraminatebetagalactosamidealpha2,3sialyltransferase
MVSKSRWKLLAMLALVLVVMVWYSISREDRYIELFYFPIPEKKEPCLQGEAESKASKLFG
NYSRDQPIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRVLAITSSSIPKNIQSLRCRRC
VVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVE
NNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIA
ADKLLSLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYNKKQTIHYYEQIT
LKSMAGSGHNVSQEALAIKRMLEMGAIKNLTSF

# Metabolic_Enzyme_26_Number_of_Residues:
333

# Metabolic_Enzyme_26_Molecular_Weight:
38046

# Metabolic_Enzyme_26_Theoretical_pI:
9.88

# Metabolic_Enzyme_26_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  sialyltransferase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  intrinsic to organelle membrane
Component:  intrinsic to Golgi membrane
Component:  integral to Golgi membrane

# Metabolic_Enzyme_26_General_Function:
Not Available

# Metabolic_Enzyme_26_Specific_Function:
It may catalyze the formation of the NeuAc-alpha-2,3- Gal-beta-1,3-GalNAc- or NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant

# Metabolic_Enzyme_26_Pathway:
Not Available

# Metabolic_Enzyme_26_Reaction:
Not Available

# Metabolic_Enzyme_26_Pfam_Domain_Function:
PF00777:Glyco_transf_29

# Metabolic_Enzyme_26_Signals:
1-26

# Metabolic_Enzyme_26_Transmembrane_Regions:
9-26

# Metabolic_Enzyme_26_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_26_EC_Link:
EC 2.4.99.4

# Metabolic_Enzyme_26_GenBank_ID_Protein:
431315

# Metabolic_Enzyme_26_SwissProt_ID:
SIA4C_HUMAN (Q11206)

# Metabolic_Enzyme_26_swissprot_Name:
Not Available

# Metabolic_Enzyme_26_Genecard_id:
ST3GAL4

# Metabolic_Enzyme_26_Geneatlas_id:
ST3GAL4

# Metabolic_Enzyme_26_hgnc_id:
HGNC:10864

# Metabolic_Enzyme_26_PDB_ID:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_26_Subcellular_Location:
Golgi apparatus; Golgi stack; Golgi stack membrane; single-pass type II membrane protein. Secreted protein. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid

# Metabolic_Enzyme_26_Gene_Sequence:
>999 bp
ATGTGTCCTGCAGGCTGGAAGCTCCTGGCCATGTTGGCTCTGGTCCTGGTCGTCATGGTG
TGGTATTCCATCTCCCGGGAAGACAGGTACATCGAGCTTTTTTATTTTCCCATCCCAGAG
AAGAAGGAGCCGTGCCTCCAGGGTGAGGCAGAGAGCAAGGCCTCTAAGCTCTTTGGCAAC
TACTCCCGGGATCAGCCCATCTTCCTGCGGCTTGAGGATTATTTCTGGGTCAAGACGCCA
TCTGCTTACGAGCTGCCCTATGGGACCAAGGGGAGTGAGGATCTGCTCCTCCGGGTGCTA
GCCATCACCAGCTCCTCCATCCCCAAGAACATCCAGAGCCTCAGGTGCCGCCGCTGTGTG
GTCGTGGGGAACGGGCACCGGCTGCGGAACAGCTCACTGGGAGATGCCATCAACAAGTAC
GATGTGGTCATCAGATTGAACAATGCCCCAGTGGCTGGCTATGAGGGTGACGTGGGCTCC
AAGACCACCATGCGTCTCTTCTACCCTGAATCTGCCCACTTCGACCCCAAAGTAGAAAAC
AACCCAGACACACTCCTCGTCCTGGTAGCTTTCAAGGCAATGGACTTCCACTGGATTGAG
ACCATCCTGAGTGATAAGAAGCGGGTGCGAAAGGGTTTCTGGAAACAGCCTCCCCTCATC
TGGGATGTCAATCCTAAACAGATTCGGATTCTCAACCCCTTCTTCATGGAGATTGCAGCT
GACAAACTGCTGAGCCTGCCAATGCAACAGCCACGGAAGATTAAGCAGAAGCCCACCACG
GGCCTGTTGGCCATCACGCTGGCCCTCCACCTCTGTGACTTGGTGCACATTGCCGGCTTT
GGCTACCCAGACGCCTACAACAAGAAGCAGACCATTCACTACTATGAGCAGATCACGCTC
AAGTCCATGGCGGGGTCAGGCCATAATGTCTCCCAAGAGGCCCTGGCCATTAAGCGGATG
CTGGAGATGGGAGCTATCAAGAACCTCACGTCCTTCTGA

# Metabolic_Enzyme_26_GenBank_ID_Gene:
L23767

# Metabolic_Enzyme_26_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_26_Locus:
11q23-q24

# Metabolic_Enzyme_26_SNPs:
rs2298475; rs2230278; rs2230279; rs1007690; rs10893499; rs6590203; rs2186716; rs12576289; rs2186717; rs6590202; rs7940893; rs3862628; rs7928391; rs7130320; rs7110951; rs4055111; rs6590199; rs4937122; rs10893505; rs11220465; rs2269395; rs7395043; rs11603211; rs10893506; rs12574844; rs10893502; rs4480556; rs7118117; rs10893498; rs629882; rs12280645; rs11220472; rs7951028; rs10893500; rs3862629; rs7933887; rs12274111; rs11220477; rs10790801; rs9704688; rs11220468; rs7948413; rs7941034; rs4477452; rs1049494; rs10893504; rs11220462; rs4307732; rs4278528; rs11220473; rs12283025; rs4245067; rs10790800; rs644682; rs12226757; rs7129728; rs11220476; rs7121123; rs12276289; rs7103461; rs4390359; rs12285472; rs7952602; rs7927540; rs7951067; rs11827374; rs1893351; rs11220475; rs12282685; rs4601794; rs11822130; rs6590201; rs617120; rs656841; rs10893503; rs2066985; rs683486; rs601698; rs12276174; rs12287293; rs1049496; rs10893501; rs11220461; rs601713; rs11220463; rs11220471; rs6590204; rs4937124; rs4935965; rs1316361; rs7116008; rs2236653; rs10790802; rs2105621; rs3781781; rs3781780; rs11220480; rs2298476; rs4937126; rs4937125; rs7937122; rs583823; rs11559148; rs11220478; rs11220459; rs5795492; rs617707; rs12288461; rs10599019; rs11418300; rs34805062; rs35178220; rs11443803; rs7104548; rs4505078; rs6590200; rs12290068; rs12224231; rs617731; rs10683946; rs36007989; rs5015997; rs34984135; rs7924539; rs4055126; rs11220464; rs35680660; rs7109231; rs17135420; rs12420588; rs12281624; rs7934464; rs12293992; rs617747; rs4055110; rs3967203; rs4579935; rs35224938; rs602634; rs35215127; rs5795493; rs34173605; rs680274; rs10690383; rs633190; rs12271752; rs35681864; rs3967200; rs35640929; rs34503705; rs1786701; rs35652926; rs3862630; rs10570729; rs7928577; rs12291836; rs12804228; rs4055125; rs2322188; rs4055123; rs10673254; rs11379700; rs5015998; rs4393322; rs35823964; rs618902; rs10698813; rs35099186; rs12289579; rs35364902; rs633205; rs680316; rs679815; rs35107789; rs36178456; rs12288031; rs1695738; rs34853752; rs12225592; rs679845; rs34527614; rs5016002; rs12286588; rs11351520; rs34395602; rs12281220; rs12278170; rs34912432; rs5016000; rs11286424; rs656711; rs34002567; rs11220457; rs35202611; rs3967201; rs679904; rs4055124; rs35195886; rs3967204; rs11220466; rs11423373; rs4055122; rs11285554; rs33999160; rs35175644; rs12281560; rs11271003; rs12289389; rs3758831; rs7118123; rs5015999; rs5795491; rs7947866; rs35544919; rs4055109; rs12791939; rs12284180; rs11220467; rs617765; rs35957008; rs5016001; rs36046161; rs4055127; rs11311913; rs11384678; rs34092932; rs35118834; rs3967202; rs12798316; rs35156054; rs11220474; rs10627600; rs5015996; rs4055121; rs12278171; rs12283613; rs28650981; rs11220479; rs11220481; rs12273885; rs12793028; rs35692578; rs2848583; rs11220482; rs240528; rs240529; rs34736747; rs10629345; rs11220483; rs583469; rs34432370; rs240527; rs35613657; rs10893507; rs11220486; rs12288924; rs17135399; rs17135401; rs2155311; rs2298473; rs2697; rs3017010; rs3212318; rs34642230; rs34819998; rs35600242; rs35887873; rs3802815; rs4312076; rs4323873; rs4553380; rs4935966; rs4935967; rs4937127; rs4937128; rs582037; rs622167; rs6590198; rs7113456; rs7113465; rs752805; rs752806; rs752807; rs7949566; rs873938; rs948053; rs948054; rs948055

# Metabolic_Enzyme_26_General_References:
8557707; 8288606; 7901202; 8611500

# Metabolic_Enzyme_26_References:
Not Available

# Metabolic_Enzyme_27_ID:
8749

# Metabolic_Enzyme_27_Name:
Cytosolic 5'-nucleotidase III

# Metabolic_Enzyme_27_Synonyms:
cN-III; Pyrimidine 5'- nucleotidase 1; P5'N-1; P5N-1; PN-I; Uridine 5'-monophosphate hydrolase 1; p36

# Metabolic_Enzyme_27_Gene_Name:
NT5C3

# Metabolic_Enzyme_27_Protein_Sequence:
>Cytosolic 5'nucleotidase 
IIIMRAPSMDRAAVARVGAVASASVCALVAGVVLAQYIFTLKRKTGRKTKIIEMMPEFQK
SSVRIKNPTRVEEIICGLIKGGAAKLQIITDFDMTLSRFSYKGKRCPTCHNIIDNCKLVT
DECRKKLLQLKEKYYAIEVDPVLTVEEKYPYMVEWYTKSHGLLVQQALPKAKLKEIVAES
DVMLKEGYENFFDKLQQHSIPVFIFSAGIGDVLEEVIRQAGVYHPNVKVVSNFMDFDETG
VLKGFKGELIHVFNKHDGALRNTEYFNQLKDNSNIILLGDSQGDLRMADGVANVEHILKI
GYLNDRVDELLEKYMDSYDIVLVQDESLEVANSILQKIL

# Metabolic_Enzyme_27_Number_of_Residues:
336

# Metabolic_Enzyme_27_Molecular_Weight:
37949

# Metabolic_Enzyme_27_Theoretical_pI:
7.15

# Metabolic_Enzyme_27_GO_Classification:
Not Available

# Metabolic_Enzyme_27_General_Function:
Not Available

# Metabolic_Enzyme_27_Specific_Function:
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate

# Metabolic_Enzyme_27_Pathway:
map00230  Purine metabolism
 map00240  Pyrimidine metabolism
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_27_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_27_Pfam_Domain_Function:
PF05822:UMPH-1

# Metabolic_Enzyme_27_Signals:
1-32

# Metabolic_Enzyme_27_Transmembrane_Regions:
13-35

# Metabolic_Enzyme_27_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_27_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_27_GenBank_ID_Protein:
11245474

# Metabolic_Enzyme_27_SwissProt_ID:
5NT3_HUMAN (Q9H0P0)

# Metabolic_Enzyme_27_swissprot_Name:
Not Available

# Metabolic_Enzyme_27_Genecard_id:
NT5C3

# Metabolic_Enzyme_27_Geneatlas_id:
NT5C3

# Metabolic_Enzyme_27_hgnc_id:
HGNC:17820

# Metabolic_Enzyme_27_PDB_ID:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_27_Subcellular_Location:
Cytoplasm (Potential). Isoform 2:Endoplasmic reticulum

# Metabolic_Enzyme_27_Gene_Sequence:
>861 bp
ATGATGCCAGAATTCCAGAAAAGTTCAGTTCGAATCAAGAACCCTACAAGAGTAGAAGAA
ATTATCTGTGGTCTTATCAAAGGAGGAGCTGCCAAACTTCAGATAATAACGGACTTTGAT
ATGACACTCAGTAGATTTTCATATAAAGGGAAAAGATGCCCAACATGTCATAATATCATT
GACAACTGTAAGCTGGTTACAGATGAATGTAGAAAAAAGTTATTGCAACTAAAGGAAAAA
TACTACGCTATTGAAGTTGATCCTGTTCTTACTGTAGAAGAGAAGTACCCTTATATGGTG
GAATGGTATACTAAATCACATGGTTTGCTTGTTCAGCAAGCTTTACCAAAAGCTAAACTT
AAAGAAATTGTGGCAGAATCTGACGTTATGCTCAAAGAAGGATATGAGAATTTCTTTGAT
AAGCTCCAACAACATAGCATCCCCGTGTTCATATTTTCGGCTGGAATCGGCGATGTACTA
GAGGAAGTTATTCGTCAAGCTGGTGTTTATCATCCCAATGTCAAAGTTGTGTCCAATTTT
ATGGATTTTGATGAAACTGGGGTGCTCAAAGGATTTAAAGGAGAACTAATTCATGTATTT
AACAAACATGATGGTGCCTTGAGGAATACAGAATATTTCAATCAACTAAAAGACAATAGT
AACATAATTCTTCTGGGAGACTCCCAAGGAGACTTAAGAATGGCAGATGGAGTGGCCAAT
GTTGAGCACATTCTGAAAATTGGATATCTAAATGATAGAGTGGATGAGCTTTTAGAAAAG
TACATGGACTCTTATGATATTGTTTTAGTACAAGATGAATCATTAGAAGTAGCCAACTCT
ATTTTACAGAAGATTCTATAA

# Metabolic_Enzyme_27_GenBank_ID_Gene:
AF312735

# Metabolic_Enzyme_27_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_27_Locus:
7p14.3

# Metabolic_Enzyme_27_SNPs:
rs3750117; rs17170223; rs7806813; rs6946062; rs4723241; rs7792135; rs6415262; rs7795860; rs7796184; rs4723242; rs10230500; rs4723239; rs6462452; rs10085768; rs10256717; rs4338000; rs6462453; rs10233749; rs10281012; rs10280692; rs10251079; rs7801986; rs4720098; rs7778958; rs10951370; rs6948212; rs6462451; rs10231011; rs4316067; rs10951371; rs7800610; rs4445128; rs7803427; rs6948759; rs6976301; rs17170264; rs6954923; rs6968519; rs1609410; rs6956397; rs7776847; rs4723240; rs10241653; rs17170228; rs1881749; rs10807866; rs12534758; rs12672785; rs7801701; rs4720100; rs10486512; rs10951372; rs12672827; rs6954699; rs12532475; rs10238911; rs10247806; rs1609543; rs1881750; rs6947507; rs12536321; rs1609407; rs6946539; rs2049758; rs3750119; rs4720097; rs2392208; rs2893457; rs6462449; rs3750118; rs6955792; rs10242882; rs4723235; rs4562213; rs2392211; rs6462450; rs7793793; rs4236335; rs2392209; rs6942974; rs3793328; rs12155477; rs2392210; rs17385980; rs4723234; rs6965942; rs10270155; rs12668520; rs4720095; rs10269519; rs17170218; rs4565371; rs4286846; rs6961785; rs7798138; rs17170153; rs7798538; rs10951369; rs10240662; rs6962945; rs3793329; rs11532669; rs17170151; rs3793331; rs6462448; rs10267080; rs16879126; rs17170172; rs7790368; rs17170180; rs7788623; rs3793330; rs11767244; rs7809021; rs4720094; rs11974256; rs17470890; rs6462445; rs7792057; rs6462446; rs6462444; rs10266244; rs10262141; rs13438699; rs17170045; rs6976843; rs35152518; rs12113572; rs35420404; rs11769843; rs12111676; rs28623683; rs35671236; rs10582278; rs11760453; rs7779477; rs17471190; rs11453440; rs5883381; rs6462454; rs34316079; rs34195150; rs2392214; rs6943638; rs7810269; rs13222705; rs36169043; rs12533799; rs2893460; rs35152276; rs11390691; rs10254146; rs35691055; rs35109630; rs17471162; rs11547833; rs35207287; rs11382973; rs11395770; rs5883380; rs35818020; rs11390690; rs1581684; rs10582277; rs28728209; rs28473079; rs17471313; rs3082829; rs6943893; rs13224861; rs11395769; rs11382972; rs28501096; rs17471224; rs34813051; rs11773636; rs35338263; rs11388536; rs11414093; rs2392212; rs11407169; rs34974224; rs11392423; rs12531081; rs2893459; rs13222706; rs35390311; rs13237339; rs35666265; rs4720099; rs12666128; rs6968844; rs10584675; rs2392213; rs34121210; rs10586164; rs10260952; rs34311705; rs34135622; rs28439161; rs17471015; rs10691796; rs6965006; rs28622104; rs34838392; rs11407650; rs12154853; rs4723236; rs28619883; rs34938098; rs7782604; rs34359635; rs4720096; rs11336828; rs35180909; rs34628314; rs28382383; rs34862244; rs36051367; rs36110783; rs28576352; rs11439369; rs6963198; rs7797997; rs34317509; rs4723238; rs35312649; rs34834341; rs4000127; rs11437974; rs5883379; rs28506936; rs34501041; rs36099404; rs6965241; rs17470945; rs4000126; rs35588427; rs12155117; rs11434167; rs34416274; rs35769309; rs11286607; rs4723237; rs34947432; rs2893458; rs17470792; rs13228827; rs10248436; rs13228639; rs34307182; rs34567230; rs10252880; rs10253348; rs12538619; rs2893461; rs2893462; rs4330597; rs4394301; rs4454197; rs4604334; rs4720093; rs4723232; rs4723233; rs4723244; rs6953386; rs7802256

# Metabolic_Enzyme_27_General_References:
10942414; 11230166; 11042152; 8557639

# Metabolic_Enzyme_27_References:
Not Available

# Metabolic_Enzyme_28_ID:
8788

# Metabolic_Enzyme_28_Name:
OTTHUMP00000022210

# Metabolic_Enzyme_28_Synonyms:
Not Available

# Metabolic_Enzyme_28_Gene_Name:
RP11-203J24.3

# Metabolic_Enzyme_28_Protein_Sequence:
>
OTTHUMP00000022210MACSRPPSQCEPTSLPPGPPAGRRHLPLSRRRREMSSNKEQR
SAVFVILFALITILILYSSNSANEVFHYGSLRGRSRRPVNLKKWSITDGYVPILGNKTLP
SRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVF
RVLRRPQEFVNRTPETVFIFWGPPSKMQKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQ
FDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPPNYCSGPASSACPTTT
TSPRGRTNVSPTSRMSTVARATTTASSPRKGSSHRGPSCMASPSPTPPGPRPPSLWDLRR
VRGEAASAQPLGQGPSSGQSRLAGVSPSQSGP

# Metabolic_Enzyme_28_Number_of_Residues:
374

# Metabolic_Enzyme_28_Molecular_Weight:
40781

# Metabolic_Enzyme_28_Theoretical_pI:
11.10

# Metabolic_Enzyme_28_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  sialyltransferase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  intrinsic to organelle membrane
Component:  intrinsic to Golgi membrane
Component:  integral to Golgi membrane

# Metabolic_Enzyme_28_General_Function:
Not Available

# Metabolic_Enzyme_28_Specific_Function:
Not Available

# Metabolic_Enzyme_28_Pathway:
Not Available

# Metabolic_Enzyme_28_Reaction:
Not Available

# Metabolic_Enzyme_28_Pfam_Domain_Function:
PF00777:Glyco_transf_29

# Metabolic_Enzyme_28_Signals:
Not Available

# Metabolic_Enzyme_28_Transmembrane_Regions:
43-60

# Metabolic_Enzyme_28_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_28_EC_Link:
EC 2.4.99.-

# Metabolic_Enzyme_28_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_28_SwissProt_ID:
Q5T9C4_HUMAN (Q5T9C4)

# Metabolic_Enzyme_28_swissprot_Name:
Not Available

# Metabolic_Enzyme_28_Genecard_id:
ST6GALNAC6

# Metabolic_Enzyme_28_Geneatlas_id:
ST6GALNAC6

# Metabolic_Enzyme_28_hgnc_id:
HGNC:23364

# Metabolic_Enzyme_28_PDB_ID:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_28_Subcellular_Location:
Membrane

# Metabolic_Enzyme_28_Gene_Sequence:
Not Available

# Metabolic_Enzyme_28_GenBank_ID_Gene:
AL157935

# Metabolic_Enzyme_28_Chromosome_Location:
Not Available

# Metabolic_Enzyme_28_Locus:
Not Available

# Metabolic_Enzyme_28_SNPs:
Not Available

# Metabolic_Enzyme_28_General_References:
Not Available

# Metabolic_Enzyme_28_References:
Not Available

# Metabolic_Enzyme_29_ID:
8796

# Metabolic_Enzyme_29_Name:
Sat-2 short

# Metabolic_Enzyme_29_Synonyms:
Not Available

# Metabolic_Enzyme_29_Gene_Name:
ST8SIA1

# Metabolic_Enzyme_29_Protein_Sequence:
>Sat2 short
MSPCGRARRQTSRGAMAVLAWKFPRTRLPMGASALCVVVLCWLYIFPVYRLPNEKEIVQG
VLQQGTAWRRNQTAARAFRKQMEDCCDPAHLFAMTKMNSPMGKSMWYDGEFLYSFTIDNS
TYSLFPQMQSPSFVK

# Metabolic_Enzyme_29_Number_of_Residues:
135

# Metabolic_Enzyme_29_Molecular_Weight:
15504

# Metabolic_Enzyme_29_Theoretical_pI:
10.02

# Metabolic_Enzyme_29_GO_Classification:
Not Available

# Metabolic_Enzyme_29_General_Function:
Not Available

# Metabolic_Enzyme_29_Specific_Function:
Not Available

# Metabolic_Enzyme_29_Pathway:
Not Available

# Metabolic_Enzyme_29_Reaction:
Not Available

# Metabolic_Enzyme_29_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_29_Signals:
1-50

# Metabolic_Enzyme_29_Transmembrane_Regions:
30-49

# Metabolic_Enzyme_29_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_29_EC_Link:
EC 2.4.99.8

# Metabolic_Enzyme_29_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_29_SwissProt_ID:
Q6PZN5_HUMAN (Q6PZN5)

# Metabolic_Enzyme_29_swissprot_Name:
Not Available

# Metabolic_Enzyme_29_Genecard_id:
ST8SIA1

# Metabolic_Enzyme_29_Geneatlas_id:
ST8SIA1

# Metabolic_Enzyme_29_hgnc_id:
HGNC:10869

# Metabolic_Enzyme_29_PDB_ID:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_29_Subcellular_Location:
Membrane

# Metabolic_Enzyme_29_Gene_Sequence:
Not Available

# Metabolic_Enzyme_29_GenBank_ID_Gene:
AY569975

# Metabolic_Enzyme_29_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_29_Locus:
12p12.1-p11.2

# Metabolic_Enzyme_29_SNPs:
rs704219; rs3803101; rs1803638; rs918099; rs1558793; rs1861606; rs2900502; rs2728824; rs2300715; rs1019332; rs2017107; rs2728829; rs2300718; rs2041906; rs2300726; rs2728825; rs2728822; rs2300717; rs2541300; rs2728827; rs1362601; rs2300739; rs1155392; rs11615329; rs2193180; rs2300728; rs4762892; rs1987940; rs2300721; rs2728821; rs3782524; rs2300738; rs11614265; rs1345412; rs2300725; rs11046348; rs7134252; rs722248; rs2012936; rs7312306; rs2728818; rs2284849; rs2300729; rs12828366; rs2111177; rs11046351; rs6487295; rs11608373; rs11046344; rs976709; rs2160536; rs1160783; rs4762894; rs734554; rs3819868; rs7301632; rs4762898; rs4762901; rs7963388; rs2193178; rs10459079; rs7970824; rs7958065; rs4762895; rs2300735; rs10770899; rs2300731; rs2728826; rs4762904; rs7297765; rs976710; rs2541303; rs2216228; rs10841976; rs1014433; rs11611833; rs3819878; rs16924749; rs1019331; rs17703131; rs1158409; rs741371; rs2268857; rs12310364; rs2284854; rs2012722; rs7953875; rs10841978; rs759530; rs12813971; rs1420630; rs7310117; rs11830582; rs11838002; rs10841979; rs2728828; rs2300712; rs11610532; rs11046350; rs10841986; rs12310517; rs4133369; rs4762896; rs2300719; rs10841984; rs9919724; rs16924828; rs2072542; rs2541299; rs741370; rs12099876; rs1960265; rs7966606; rs17704613; rs7314460; rs16924859; rs12297315; rs7316302; rs12302876; rs2268858; rs2268861; rs741369; rs2193179; rs11611999; rs7307161; rs2418055; rs2287169; rs10841983; rs11833651; rs2728817; rs12826088; rs16924844; rs11836129; rs2012613; rs2300737; rs3782525; rs11046355; rs10492282; rs3782526; rs7956389; rs2300732; rs16924767; rs17653452; rs11613665; rs2284853; rs10841982; rs2541302; rs12310040; rs7132895; rs2016977; rs2193177; rs11614453; rs4098994; rs2418057; rs10841977; rs7307537; rs16924832; rs7962240; rs12321356; rs2216227; rs7311793; rs11610434; rs2900501; rs11613227; rs12825106; rs10492283; rs2300740; rs11611401; rs2300727; rs17646466; rs11832631; rs7296325; rs1345413; rs10841987; rs17646831; rs10841974; rs11834129; rs7311007; rs10841980; rs7964012; rs7132027; rs11837885; rs11612221; rs4762899; rs2541301; rs11612147; rs11046353; rs2300720; rs12815461; rs7295402; rs3819873; rs16924898; rs11612801; rs2284848; rs12823181; rs2268856; rs11613477; rs11835023; rs2541298; rs2300716; rs2300734; rs2728823; rs7971462; rs7312773; rs2287166; rs2216229; rs11613570; rs7956659; rs10047668; rs12321369; rs12815963; rs7956227; rs6487297; rs12314813; rs16924777; rs3819867; rs12301177; rs7959390; rs17702101; rs981884; rs976711; rs16924864; rs7311021; rs2728820; rs16924880; rs34312316; rs4325353; rs10841973; rs12315759; rs2284852; rs3819879; rs16924850; rs12309232; rs16924787; rs2300733; rs11608405; rs12818857; rs7962800; rs7960627; rs2300722; rs16924821; rs12820379; rs11046367; rs7965135; rs17702788; rs12813030; rs11611356; rs2418058; rs2193181; rs16924854; rs16924866; rs2216230; rs12817074; rs16924815; rs9739131; rs7976824; rs3819866; rs7978882; rs10841975; rs4762739; rs16924858; rs16924758; rs1420629; rs2300714; rs2287168; rs35947550; rs2098412; rs7310760; rs7297807; rs12317347; rs12826736; rs12815085; rs6487296; rs3825254; rs2216231; rs2300723; rs16924835; rs7296627; rs12828939; rs7298767; rs3819865; rs1420627; rs17702940; rs17645440; rs7953421; rs2300736; rs3819872; rs741368; rs11046347; rs12816677; rs7312718; rs2300713; rs16924857; rs17653482; rs12827101; rs11046357; rs1985103; rs12303299; rs7135998; rs2728819; rs3782523; rs7294520; rs7961947; rs1420628; rs2287167; rs35486967; rs7487656; rs7977156; rs12824390; rs3819877; rs10841981; rs7488721; rs7306930; rs11609191; rs741373; rs11046362; rs10841985; rs4762737; rs7970051; rs3809201; rs12815906; rs12318055; rs10841972; rs3809202; rs35306551; rs35744997; rs12581522; rs12581521; rs3819874; rs12826179; rs12817086; rs11367158; rs34136037; rs34811401; rs34647249; rs35183171; rs3831855; rs10642644; rs2728830; rs10671911; rs34724709; rs35361835; rs35911569; rs11448343; rs11837717; rs12826536; rs34425903; rs36083303; rs3216628; rs12309948; rs10622751; rs34476732; rs5796958; rs11046363; rs35831712; rs2300730; rs12318036; rs36111754; rs12424706; rs12822143; rs12582926; rs34967112; rs36114533; rs34756870; rs12827903; rs35692052; rs3837484; rs34151958; rs2098411; rs10609876; rs34822376; rs7485100; rs35038009; rs34575551; rs2193175; rs35580365; rs35972980; rs12822313; rs12826833; rs5796954; rs3819871; rs28729097; rs12301178; rs7311722; rs11046364; rs11463657; rs7970420; rs11046356; rs4762738; rs35850622; rs11349014; rs3216630; rs11394293; rs3819875; rs12822646; rs12822153; rs35943365; rs5796955; rs34867244; rs35394244; rs35116949; rs34447515; rs35522704; rs3819869; rs12319691; rs12816254; rs35764423; rs12812546; rs4762902; rs34820200; rs12822460; rs3216629; rs9919816; rs12822607; rs35335972; rs34854158; rs34852606; rs34707453; rs11046359; rs4762897; rs12818405; rs34027017; rs35707838; rs11290260; rs35848576; rs34935354; rs11352285; rs11046345; rs12826523; rs34553797; rs35291474; rs10634712; rs34341619; rs11502698; rs4762905; rs34992184; rs12822323; rs35516385; rs12298017; rs1012675; rs3940333; rs34168353; rs35021216; rs35395680; rs12812044; rs3063800; rs12372480; rs35058755; rs35934031; rs2418056; rs11046352; rs10673826; rs11434182; rs35021352; rs35504356; rs10718948; rs35961342; rs34353400; rs2268860; rs12826918; rs34637155; rs11046346; rs35362312; rs5796956; rs7965003; rs7138635; rs35849391; rs918100; rs34095117; rs11046354; rs34090928; rs35543851; rs35109127; rs34593544; rs11046358; rs2955522; rs3063802; rs3819876; rs3216631; rs34518605; rs2268859; rs2728816; rs12827371; rs34371745; rs5796957; rs12819073; rs34578656; rs7965977; rs34415112; rs34650104; rs34954149; rs34136511; rs34056487; rs11046366; rs34181694; rs7956051; rs7303005; rs35307715; rs35109397; rs34769711; rs4366539; rs34653517; rs35698287; rs11421261; rs17703173; rs5796953; rs3216627; rs34119935; rs12822647; rs3819870; rs35002189; rs11423875; rs34617030; rs3063795; rs12579498; rs2300724; rs35794118; rs2193176; rs12811237; rs11336297; rs734555; rs11046360; rs9919725; rs35520367; rs34802684; rs3944006; rs7978750; rs35900702; rs2284857; rs11361771; rs34395687; rs35520685; rs34377192; rs34617658; rs3831856; rs7316093; rs7956855; rs35988676; rs35594380; rs10459078; rs10841988; rs11046340; rs12308957; rs12816719; rs16924743; rs2160631; rs2193380; rs2418054; rs4606528

# Metabolic_Enzyme_29_General_References:
Not Available

# Metabolic_Enzyme_29_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8712

# Macromolecular_Interacting_Partner_1_Name:
Hypothetical protein DKFZp313G0615

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
DKFZp313G0615

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Hypothetical protein DKFZp313G0615
MSGHRSTRKRCGDSHPESPVGFGHMSTTGCVLNKLFQLPTPPLSRHQLKRLEEHRYQSAG
RSLLEPLMQGYWEWLVRRVPSWIAPNLITIIGLSINICTTILLVFYCPTATEQAPLWAYI
ACACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLST

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
162

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
18105

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
8.29

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
 Function:  Not Available
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  phospholipid metabolism
Process:  phospholipid biosynthesis
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01066:CDP-OH_P_transf

# Macromolecular_Interacting_Partner_1_Signals:
Not Available

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
83-105; 115-132

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
Q69YJ9_HUMAN (Q69YJ9)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
CEPT1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
CEPT1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:24289

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AL833102

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Locus:
Not Available

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
Not Available

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8724

# Macromolecular_Interacting_Partner_2_Name:
PGS1 protein

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
PGS1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>PGS1 protein
RVSMAVAAAAAAGPVFWRRLLGLLPGRPGLAALLGRLSDRLGRNRDRQRRRSPWLLLAPL
LSPAVPQVTSPPCCLCPEGVHRFQWIRNLVPEFGVSSSHVRVLSSPAEFFELMKVDCLES
TLEKSLQAKFPSNLKVSILLDFTRGSRGRKNSRTMLLPLLRRFPEQVRVSLFHTPHLRGL
LRLLIPERFNETIGLQHIKVYLFDNSVILSGANLSDSYFTNRQDRYVFLQDCAEIADFFT
ELVDAVGDVSLQLQGDDTVQVVDGMVHPYKGDRAEYCKAANKRVMDVINSARTRQQMLHA
QTFHSNSLLTQEDAAAAGDRRPAPDTWIYPLIQMKPFEIQIDEIVTETLLTEAERGAKVY
LTTGYFNLTQAYMDLVLGTRAEYQILLASPEVNGFFGPRGWPAPSQRPMCTSSDSSSVRC
AAWDSRSGSSFRSTGGGAGRSTPKVSSPGPGGPDCDRDGEPGPAAAASPGARAALPEVRC
GVLCHLRAAESPGEAVGEDGDSTDQELLLRTDRNGLDEDDRHGRGQLFQPRFSDDSSLGV
PASPCRDSMAEGQVCCQ

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
557

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
61141

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
7.20

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  catalytic activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Lipid transport and metabolism

# Macromolecular_Interacting_Partner_2_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00614:PLDc

# Macromolecular_Interacting_Partner_2_Signals:
1-31

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
Q8IYK9_HUMAN (Q8IYK9)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
PGS1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
PGS1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:30029

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
BC035662

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_2_Locus:
17q25.3

# Macromolecular_Interacting_Partner_2_SNPs:
rs2292642; rs34088225; rs2376585; rs8071516; rs6501210; rs16971246; rs2138127; rs7208969; rs938350; rs2292644; rs11077363; rs4969143; rs7208596; rs4082919; rs4969178; rs4490057; rs2292640; rs938348; rs4969182; rs7212201; rs4969183; rs8071889; rs1540773; rs4129767; rs8072632; rs938351; rs4969186; rs2376583; rs3817295; rs9900564; rs8075131; rs4969142; rs1976704; rs938346; rs12453354; rs11077362; rs11871046; rs12453219; rs4969187; rs2090205; rs6501209; rs938347; rs11077361; rs6501208; rs4366775; rs11077364; rs16971105; rs3744216; rs2292643; rs4969179; rs4580257; rs4969144; rs2292641; rs11871028; rs3817294; rs7220865; rs17561950; rs2292645; rs4246438; rs16971107; rs4969184; rs12453603; rs17642548; rs7225914; rs11658146; rs12451109; rs16971236; rs9900792; rs12603140; rs8071552; rs7219215; rs12600422; rs3744217; rs1976703; rs12944051; rs938349; rs12450784; rs8071884; rs12601079; rs8073753; rs8072666; rs7225074; rs7221708; rs3744219; rs1968014; rs16971108; rs11867998; rs11657865; rs12453598; rs11657860; rs12150497; rs3826323; rs9900494; rs12450528; rs8077859; rs11656568; rs8069695; rs11657987; rs9901493; rs3744218; rs11651970; rs2063792; rs4969176; rs4969185; rs12452576; rs9901724; rs7219625; rs2376584; rs9901475; rs9891030; rs11653305; rs11655397; rs4969180; rs1814847; rs11653383; rs34833500; rs11449829; rs34937257; rs35046735; rs11268248; rs1139220; rs10977; rs1139218; rs1139223; rs10535561; rs12600914; rs1139221; rs10582335; rs3198068; rs4013606; rs7219674; rs12948394; rs35879509; rs11871647; rs8076277; rs35683208; rs7222111; rs10614866; rs34040603; rs9915500; rs10599133; rs4365353; rs34728397; rs34032688; rs12602206; rs8072820; rs10522107; rs34669930; rs3833108; rs4969141; rs28617527; rs12938284; rs8068516; rs1996229; rs4969177; rs8068866; rs12942811; rs35157694; rs5016938; rs34954607; rs35076134; rs12938572; rs35729867; rs12936112; rs9911769; rs10577356; rs28632046; rs12452647; rs5822252; rs36091608; rs12602692; rs4600525; rs10642898; rs7225217; rs12451715; rs12103714; rs7222619; rs12938571; rs5822251; rs4073934; rs10544232; rs35959287; rs35005537; rs12943030; rs7221930; rs9910613; rs12451056; rs35635587; rs35472026; rs35895090; rs35550812; rs12936764; rs8070806; rs34252361; rs4969181; rs7226256; rs5822253; rs36077709; rs4129768; rs35446090; rs11321162; rs3031603; rs33931168; rs35668021; rs10599132; rs12600411; rs10523020; rs12451791; rs34885272; rs9892707; rs34385648; rs4969145; rs34779407; rs12948949; rs3744220; rs12450500; rs10564375; rs34348117; rs12939451; rs9912930; rs34162262; rs34029669; rs5822250; rs11344447; rs34856467; rs12936797; rs4461143; rs9896278; rs34400166; rs12938809; rs12936808; rs4969174; rs11354596; rs12936558; rs4969175; rs35845066; rs34149030; rs1036990; rs12601655; rs12942703; rs1623869; rs1631200; rs1964450; rs2048754; rs2271613; rs3209030; rs34094807; rs35081093; rs35422926; rs35597902; rs35782078; rs35879621; rs35973257; rs36119275; rs4527079; rs4969172; rs4969188; rs589582; rs618324; rs618329; rs618842; rs6501213; rs650889; rs651806; rs666463; rs680027; rs690752; rs691061; rs691094; rs691113; rs691277; rs691328; rs691331; rs691342; rs691346; rs691362; rs691674; rs691680; rs7222563; rs8067560; rs8069521; rs8069689; rs8069809

# Macromolecular_Interacting_Partner_2_General_References:
12477932

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8760

# Macromolecular_Interacting_Partner_3_Name:
Sialyltransferase 7

# Macromolecular_Interacting_Partner_3_Synonyms:
Alpha-N-acetylneuraminyl-2,3-beta-galactosyl- 1,3-N-acetyl galactosaminide alpha-2,6-sialyltransferase E

# Macromolecular_Interacting_Partner_3_Gene_Name:
ST6GALNAC5

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Sialyltransferase 7
MKTLMRHGLAVCLALTTMCTSLLLVYSSLGGQKERPPQQQQQQQQQQQQASATGSSQPAA
ESSTQQRPGVPAGPRPLDGYLGVADHKPLKMHCRDCALVTSSGHLLHSRQGSQIDQTECV
IRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHDLLNVSQGTVFIFWGPSSYMRRD
GKGQVYNNLHLLSQVLPRLKAFMITRHKMLQFDELFKQETGKDRYPTLGSALAGLQ

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
236

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
26262

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
10.45

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  sialyltransferase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  intrinsic to organelle membrane
Component:  intrinsic to Golgi membrane
Component:  integral to Golgi membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00777:Glyco_transf_29

# Macromolecular_Interacting_Partner_3_Signals:
1-30

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
7-29

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
Q5TG75_HUMAN (Q5TG75)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_3_hgnc_id:
Not Available

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AC099060

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_3_Locus:
1p31.1

# Macromolecular_Interacting_Partner_3_SNPs:
rs35763299; rs7543319; rs7534602; rs7547889; rs7547812; rs7534701; rs7543695; rs858598; rs1522621; rs1252597; rs1474752; rs1357329; rs858600; rs199667; rs199698; rs1252599; rs1252595; rs3107604; rs2177192; rs1252598; rs858603; rs199699; rs1252600; rs1933398; rs199677; rs11162246; rs1252485; rs4949754; rs11804149; rs1403245; rs1393656; rs199678; rs10782639; rs1698825; rs12044651; rs1252601; rs1522626; rs1766286; rs199722; rs1273142; rs4949762; rs1718920; rs1252579; rs199680; rs199679; rs1522622; rs2350526; rs1252486; rs9727199; rs858592; rs12567699; rs1883776; rs1698823; rs1933394; rs858593; rs199707; rs1522624; rs12023405; rs199693; rs1718919; rs1146671; rs1146672; rs4949753; rs1502903; rs199694; rs1146669; rs1698827; rs1718924; rs1533850; rs199676; rs1522623; rs382631; rs6663942; rs12401292; rs1718921; rs12409502; rs199688; rs2003706; rs1533849; rs6603961; rs1883778; rs10873923; rs199695; rs6658692; rs199702; rs1357331; rs1252591; rs11162236; rs2350525; rs11162232; rs17099802; rs858591; rs12734254; rs199709; rs883595; rs1546319; rs199691; rs1252588; rs17099707; rs17099761; rs9661805; rs1933399; rs1252592; rs6603932; rs858594; rs11162253; rs9660283; rs17099716; rs1252586; rs1252593; rs3113983; rs7419029; rs1522627; rs1146670; rs12118248; rs1766284; rs10873925; rs199716; rs17099699; rs11162247; rs12065122; rs199696; rs384473; rs12733883; rs1502531; rs4949758; rs1252596; rs6693427; rs9728378; rs1021810; rs199720; rs1502524; rs9658901; rs742681; rs10493599; rs6603931; rs199687; rs6669856; rs11805738; rs3107605; rs4949646; rs199689; rs6703662; rs10449705; rs2143582; rs17099717; rs7514097; rs6603930; rs11162255; rs6673583; rs3113984; rs12124645; rs199690; rs11162245; rs187956; rs12734069; rs2350527; rs1522613; rs1403244; rs1933391; rs3113985; rs1522614; rs11162233; rs1357330; rs1933395; rs11162252; rs11162249; rs17368577; rs9658903; rs3113982; rs12123266; rs1021809; rs9729082; rs199721; rs17499083; rs17558507; rs11162241; rs6662125; rs199718; rs12739214; rs3113986; rs2281305; rs11811216; rs6603933; rs6683527; rs1766283; rs12073344; rs199685; rs12084236; rs7544535; rs451650; rs4949759; rs7532720; rs1502532; rs199701; rs11806993; rs7549883; rs7540896; rs12124244; rs12048093; rs17099675; rs10782638; rs11162242; rs17099715; rs1102443; rs12725479; rs12048334; rs12081552; rs9660631; rs1847166; rs11803389; rs1403242; rs199704; rs12090582; rs12568378; rs6669597; rs199719; rs17099710; rs9659921; rs6703499; rs7521869; rs1252578; rs12128179; rs1810510; rs17099754; rs1403241; rs7530813; rs11578373; rs12097690; rs4603177; rs199686; rs6666796; rs199697; rs199692; rs199681; rs12561893; rs858595; rs17099702; rs17099696; rs1933393; rs1766287; rs12066428; rs9726451; rs1916035; rs12563595; rs7532542; rs12083259; rs7535901; rs17099686; rs17099676; rs17099793; rs742680; rs7535300; rs4949757; rs12403058; rs2859913; rs1829753; rs199717; rs7417794; rs11162244; rs10489463; rs17099700

# Macromolecular_Interacting_Partner_3_General_References:
Not Available

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8782

# Macromolecular_Interacting_Partner_4_Name:
CMP-sialic acid transporter

# Macromolecular_Interacting_Partner_4_Synonyms:
CMP-Sia-Tr; CMP-SA-Tr; Solute carrier family 35 member A1

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC35A1

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>CMPsialic acid transporter
MAAPRDNVTLLFKLYCLAVMTLMAAVYTIALRYTRTSDKELYFSTTAVCITEVIKLLLSV
GILAKETGSLGRFKASLRENVLGSPKELLKLSVPSLVYAVQNNMAFLALSNLDAAVYQVT
YQLKIPCTALCTVLMLNRTLSKLQWVSVFMLCAGVTLVQWKPAQATKVVVEQNPLLGFGA
IAIAVLCSGFAGVYFEKVLKSSDTSLWVRNIQMYLSGIIVTLAGVYLSDGAEIKEKGFFY
GYTYYVWFVIFLASVGGLYTSVVVKYTDNIMKGFSAAAAIVLSTIASVMLFGLQITLTFA
LGTLLVCVSIYLYGLPRQDTTSIQQGETASKERVIGV

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
337

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
36779

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
9.19

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
 Function:  carbohydrate transporter activity
Function:  nucleotide-sugar transporter activity
Function:  transporter activity
Function:  carrier activity
Function:  electrochemical potential-driven transporter activity
Function:  porter activity
Function:  sugar porter activity
 ||
>>>
 Process:  nucleotide-sugar transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  carbohydrate transport
 ||
>>>
 Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane
Component:  organelle membrane
Component:  Golgi membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF04142:Nuc_sug_transp

# Macromolecular_Interacting_Partner_4_Signals:
1-24

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
10-30
43-63
140-160
175-195
213-233
238-258
288-308

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
1669558

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
S35A1_HUMAN (P78382)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC35A1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC35A1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11021

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1014 bp
ATGGCTGCCCCGAGAGACAATGTCACTTTATTATTCAAGTTATACTGCTTGGCAGTGATG
ACCCTGATGGCTGCAGTCTATACCATAGCTTTAAGATACACAAGGACATCAGACAAAGAA
CTCTACTTTTCAACGACAGCCGTGTGTATCACAGAAGTTATAAAGTTATTGCTAAGTGTG
GGAATTTTAGCTAAAGAAACTGGTAGTCTGGGTAGATTCAAAGCATCTTTAAGAGAAAAT
GTCTTGGGGAGCCCCAAGGAACTGTTGAAGTTAAGTGTGCCATCGTTAGTGTATGCTGTT
CAGAACAACATGGCTTTCCTAGCTCTTAGCAATCTGGATGCAGCAGTGTACCAGGTGACC
TACCAGTTGAAGATTCCGTGTACTGCTTTATGCACTGTTTTAATGTTAAATCGGACACTC
AGCAAATTACAGTGGGTTTCAGTTTTTATGCTGTGTGCTGGAGTTACGCTTGTACAGTGG
AAACCAGCCCAAGCTACAAAAGTGGTGGTGGAACAAAATCCATTATTAGGGTTTGGCGCT
ATAGCTATTGCTGTATTGTGCTCAGGATTTGCAGGAGTATATTTTGAAAAAGTTTTAAAG
AGTTCAGATACTTCTCTTTGGGTGAGAAACATTCAAATGTATCTATCAGGGATTATTGTG
ACATTAGCTGGCGTCTACTTGTCAGATGGAGCTGAAATTAAAGAAAAAGGATTTTTCTAT
GGTTACACATATTATGTCTGGTTTGTCATCTTTCTTGCAAGTGTTGGTGGCCTCTACACT
TCTGTTGTGGTTAAGTACACAGACAACATCATGAAAGGCTTTTCTGCAGCAGCGGCCATT
GTCCTTTCCACCATTGCTTCAGTAATGCTGTTTGGATTACAGATAACACTCACCTTTGCC
CTGGGTACTCTTCTTGTATGTGTTTCCATATATCTCTATGGATTACCCAGACAAGACACT
ACATCCATCCAACAAGGAGAAACAGCTTCAAAGGAGAGAGTTATTGGTGTGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
D87969

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_4_Locus:
6q15

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
9010752; 14574404

# Macromolecular_Interacting_Partner_4_References:
Not Available

# Macromolecular_Interacting_Partner_5_ID:
8790

# Macromolecular_Interacting_Partner_5_Name:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

# Macromolecular_Interacting_Partner_5_Synonyms:
GalNAc alpha-2,6-sialyltransferase II; ST6GalNAc II; Sialyltransferase 7B; SThM

# Macromolecular_Interacting_Partner_5_Gene_Name:
ST6GALNAC2

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>AlphaNacetylgalactosaminide alpha2,6sialyltransferase 2
MGLPRGSFFWLLLLLTAACSGLLFALYFSAVQRYPGPAAGARDTTSFEAFFQSKASNSWT
GKGQACRHLLHLAIQRHPHFRGLFNLSIPVLLWGDLFTPALWDRLSQHKAPYGWRGLSHQ
VIASTLSLLNGSESAKLFAPPRDTPPKCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNG
AVIKGFERDVGTKTSFYGFTVNTMKNSLVSYWNLGFTSVPQGQDLQYIFIPSDIRDYVML
RSAILGVPVPEGLDKGDRPHAYFGPEASASKFKLLHPDFISYLTERFLKSKLINTHFGDL
YMPSTGALMLLTALHTCDQVSAYGFITSNYWKFSDHYFERKMKPLIFYANHDLSLEAALW
RDLHKAGILQLYQR

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
374

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
41940

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
9.66

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  sialyltransferase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  intrinsic to organelle membrane
Component:  intrinsic to Golgi membrane
Component:  integral to Golgi membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
CMP-N-acetylneuraminate + glycano-beta-D- galactosyl-1,3-(N-acetyl-D-galactosaminyl)-glycoprotein = CMP + glycano-beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N- acetyl-D-galactosaminyl)-glycoprotein

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00777:Glyco_transf_29

# Macromolecular_Interacting_Partner_5_Signals:
1-25

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
8-28

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
6453384

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
SIA7B_HUMAN (Q9UJ37)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
ST6GALNAC2

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
ST6GALNAC2

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:10867

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1125 bp
ATGGGGCTCCCGCGCGGGTCGTTCTTCTGGCTGCTGCTCCTGCTCACGGCTGCCTGCTCG
GGGCTCCTCTTTGCCCTGTACTTCTCGGCGGTGCAGCGGTACCCGGGGCCAGCGGCCGGA
GCCAGGGACACCACATCATTTGAAGCATTCTTTCAATCCAAGGCATCGAATTCTTGGACA
GGAAAGGGCCAGGCCTGCCGACACCTGCTTCACCTGGCCATTCAGCGGCACCCCCACTTC
CGTGGCCTGTTCAATCTCTCCATTCCAGTGCTGCTGTGGGGGGACCTCTTCACCCCAGCG
CTCTGGGACCGCCTGAGCCAACACAAAGCCCCGTATGGCTGGCGGGGGCTCTCTCACCAA
GTCATCGCCTCCACCCTGAGCCTTCTGAACGGCTCAGAGAGTGCCAAGCTGTTTGCCCCG
CCCAGGGACACCCCTCCAAAGTGTATCCGGTGTGCCGTGGTGGGCAACGGAGGCATTCTG
AATGGGTCCCGCCAGGGTCCCAACATCGATGCCCATGACTATGTATTCAGACTCAATGGA
GCTGTGATCAAAGGCTTCGAGCGCGATGTGGGCACCAAGACTTCCTTCTATGGTTTCACT
GTGAACACGATGAAGAACTCCCTCGTCTCCTACTGGAATCTGGGCTTCACCTCCGTGCCA
CAAGGACAGGACCTGCAGTATATCTTCATCCCCTCAGACATCCGCGACTATGTGATGCTG
AGATCGGCCATTCTGGGCGTGCCTGTCCCTGAGGGCCTAGATAAAGGGGACAGGCCGCAC
GCCTATTTTGGACCAGAAGCCTCTGCCAGTAAATTCAAGCTGCTACATCCGGACTTCATC
AGCTACCTGACAGAAAGGTTCTTGAAATCAAAGTTGATTAACACACATTTTGGAGACCTA
TATATGCCTAGTACCGGGGCTCTCATGCTGCTGACAGCTTTGCATACCTGTGACCAGGTC
AGTGCCTATGGATTCATCACAAGCAACTACTGGAAATTTTCCGACCACTATTTCGAACGA
AAAATGAAGCCATTGATATTTTATGCAAACCACGATCTGTCCCTGGAAGCTGCCCTGTGG
AGGGACCTGCACAAGGCCGGCATCCTTCAGCTGTACCAGCGCTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AJ251053

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_5_Locus:
17q25.1

# Macromolecular_Interacting_Partner_5_SNPs:
rs2241919; rs3135934; rs1053392; rs7209626; rs4788931; rs8070052; rs8076505; rs11077829; rs10852771; rs11077834; rs2120885; rs2241918; rs11656649; rs2304921; rs2120886; rs12600489; rs2241917; rs10512610; rs4789315; rs16967307; rs12601258; rs12601888; rs11077835; rs12601644; rs11655698; rs10775368; rs2304923; rs11077831; rs3785443; rs10775369; rs9890158; rs4491558; rs10852770; rs11077839; rs3744054; rs9906851; rs11077830; rs11077837; rs8070864; rs11655255; rs11652216; rs8064651; rs11653476; rs11077833; rs7221075; rs11077838; rs12600966; rs12450319; rs2304922; rs3785444; rs8076932; rs9892510; rs11869437; rs4258648; rs7216923; rs11077832; rs10852772; rs8038; rs7353; rs9399; rs7352; rs3809700; rs1132652; rs17841620; rs3826280; rs9889807; rs11652173; rs17417958; rs1867561; rs11181; rs12449329; rs3809702; rs17513606; rs34728123; rs11276675; rs35415986; rs35067248; rs35443121; rs11654674; rs12942750; rs3785442; rs12600597; rs36047794; rs34234732; rs35657241; rs12950167; rs4789314; rs8076344; rs9900467; rs2241916; rs35397693; rs4991708; rs34557034; rs35698288; rs35145360; rs11309959; rs36026061; rs11871305; rs35150394; rs35201741; rs36043132; rs34207189; rs35016805; rs2166212; rs7207173; rs3837795; rs34696233; rs11077836; rs4788930; rs4788929; rs35253265; rs34900315; rs8069011; rs34461797; rs4789316; rs3840858; rs34653595; rs1132648; rs3809701; rs3180348; rs3837794; rs3178190; rs3911957; rs13022; rs35049285; rs1053131; rs3181002; rs28692957; rs12434; rs35720312; rs8067372; rs3840859; rs12944474; rs4789313; rs1132647; rs34079318; rs11870902; rs12601448; rs12603287; rs16969025; rs16969028; rs35658416; rs3744050; rs3744051; rs3744052; rs4471711; rs4647885; rs4647887; rs4648343; rs4788932; rs4789318; rs7219690; rs868406; rs9893133

# Macromolecular_Interacting_Partner_5_General_References:
10742600

# Macromolecular_Interacting_Partner_5_References:
Not Available

End of HMDB00095

Beginning of HMDB00097
# Accession_No:
HMDB00097

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-22 11:15:57

# biospider_lastupdate:
2007-07-12 10:51:20

# Common_Name:
Choline

# Description:
A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.  Choline is now considered to be an essential vitamin.  While humans can synthesize small amounts (by converting phosphatidylethanolamine to phosphatidylcholine), it must be consumed in the diet to maintain health.  Required levels are between 425 mg/day (female) and 550 mg/day (male).  Milk, eggs, liver and peanuts are especially rich in choline.  Most choline is found in phospholipids, namely phosphatidylcholine or lecithin.  Choline can be oxidized to form betaine, which is a methyl source for many reactions (i.e. conversion of homocysteine e to methionine).  Lack of sufficient amounts of choline in the diet can lead to a fatty liver condition and general liver damage.  This arises from the lack of VLDL, which is necessary to transport fats away from the liver.  Choline deficiency also leads to elevated serum levels of alanine amino transferase and is associated with increased incidence of liver cancer.

# Synonyms:
Choline cation; Bilineurine; (2-Hydroxyethyl)trimethyl ammonium; Bilineurin chloride; 2-hydroxy-N,N,N-trimethylethanaminium; Luridin chloride; Neocolina; (2-Hydroxyethyl)trimethylammonium chloride; Cholinium chloride; Choline chloride; Biocolina; Choline bromide; 2-Hydroxy-N,N,N-trimethylammonium chloride; Choline hydrochloride; Lipotril; Choline; Trimethyl(2-hydroxyethyl)ammonium bromide; Choline ion; Chloride de choline; Biocoline; (beta-hydroxyethyl)trimethylammonium chloride; N,N,N-trimethylethanolammonium; Hepacholine; Cholinum; (beta-hydroxyethyl)trimethylammonium; Hormocline; (2-Hydroxyethyl)trimethylammonium; Paresan; 2-hydroxy-N,N,N-trimethylethanaminium bromide

# Chemical_IUPAC_Name:
2-hydroxyethyl-trimethyl-ammonium

# Chemical_Formula:
C5H14NO

# Chemical_Structure:
tbl_chemical:::HMDB00097_ZOOM.png:::119283187530346530

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00097_THUMB.png:::119283187371823704

# Taxonomy_Kingdom:
Organic Salt

# Taxonomy_Class:
Amines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
cation; primary alcohol; quaternary ammonium salt

# Taxonomy_Biofunction:
Essential vitamins; Component of Glycerophospholipid metabolism; Component of Glycine, serine and threonine metabolism; Component of Glycosphingolipid metabolism

# Taxonomy_Source:
Exogenous

# Molecular_Weight:
104.10754

# Molecular_Weight_Avg:
104.17075

# Smiles_String_isomeric:
C[N+](C)(C)CCO

# Smiles_String_canonical:
C[N+](C)(C)CCO

# KEGG_Compound_ID:
C00114

# BioCyc_ID:
CPD-563

# PubChem_CID:
305

# PubChem_SID:
572160; 608363; 7767976; 11368276; 11461493; 6152900; 11494072; 821095; 11376438; 2233; 3414; 11360521; 828440; 11492682; 821590; 829111; 7886600; 841597; 11335282; 11485711; 590083; 11489754; 11110922; 821695; 8150565; 8143147; 12125265; 578835; 7978932; 11365714; 11374671; 11363152; 149004

# OMIM_ID:
118504; 604591; 606106; 118510; 600336; 179700; 603309; 608761; 118490; 254190; 177600; 142445; 118507; 605116; 159540; 602382; 118496; 100720; 118509; 100680; 118493; 606105; 606372; 606055; 118491; 118508; 118495; 118494; 604926; 123695; 118503; 177400; 100740; 606107; 606888; 608931; 118511; 603033; 100725; 603034; 177500; 610509; 610472; 100690; 100730; 118502; 118505; 100710

# Metagene_ID:
Not Available

# BiGG_ID:
33910

# Wikipedia_ID:
Choline

# METLIN_ID:
56

# Ref_ID:
12097436; 16236726; 14972364; 15681999; 16204714; 12703009; 15640516; 15465626; 8323976; 12196251; 16848706; 11983290; 9870205; 7762816; 16569781; 11531217; 15213044; 11443708; 12135694; 10082779

# ChEBI_ID:
15354

# CAS_Registry_Number:
62-49-7

# InChI:
InChI=1/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1

# Synthesis_Reference:
Total synthesis of (±)-isoliensinine.     Kametani, Tetsuji; Takano, Seiichi; Satoh, Kazuko.    Sch. Med.,  Univ. Tohoku,  Sendai,  Japan.    Journal of Heterocyclic Chemistry  (1966),  3(4),  546-7.

# Melting_Point:
302-303 oC (Chloride salt)

# Melting_Point_predicted:
24.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
3.61 mg/mL [Predicted by ALOGPS]; 1000 mg/mL at 25 oC [MEYLAN,WM et al. (1996)]

# phys_charge:
1

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-3.59 [Predicted by ALOGPS]; -5.16 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00097.pdf:::118425908255581661

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00097.mol:::118425908274413525

# SDF_File_[Text]:
tbl_chemical:::HMDB00097.sdf:::119283187072443160

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00097.pdb:::119283187235261402

# PDB_ID:
1GVM

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1GVM.txt:::1132720901359176159

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041027_P00_05_HW_1DP_presat.png:::114858922871567628

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041027_P00_05_HW_1DP_presat.zip:::114858922872090344

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041027_P00_05_HW_1DP_Assigned.png:::115643844320373931

# C_NMR_Spectra:
tbl_cnmr:::041027_P00_05_HW_1DC_46.jpg:::114168459605743544

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041027_P00_05_HW_1DC_46.zip:::11416845960248891

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041027_P00_05_HW_1DC_46_Assigned.jpg:::114322923061275793

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041027_P00_05_HW_2DHSQC_139.jpg:::11449555454136624

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041027_P00_05_HW_2DHSQC_139.zip:::114495554542265995

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041027_P00_05_HW_2DHSQC_139_Assigned.jpg:::11449555456039201

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Choline.gif:::1132732108328639482

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00097_peaks.txt:::1156309542065378139

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Choline_C.gif:::1132737682513856751

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00097_peaks.txt:::1156310732314779113

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000285.png:::116907445621820102

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000285.txt:::116907445621848339

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000285.png:::116890834385936706

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000285.txt:::116890834421876825

# Cellular_Location:
Cytoplasm; endoplasmic reticulum; Extracellular; golgi apparatus; mitochondria; nucleus

# Tissue_Location:
Basal Ganglia; Bladder; Brain; Epidermis; Fibroblasts; Hippocampus; Intestine; Kidney; Liver; Muscle; Myelin; Nerves; Neurons; Placenta; Platelet; Prostate; Skeletal Muscle; Spleen; Stratum Corneum; Temporal Lobe; Testes; Thalamus

# deuterated:
No

# Biofluid_Location:
Blood; Breast Milk; CSF; Saliva; Urine

# Concentration_[Normal]:
Blood	6.0 +/- 0.3	uM	Adult:>18_yrs_old	Male	Normal	10082779
Blood	27.5 +/- 3.3	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	10.6 +/- 1.9	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	>10	umol/L	Adult:>18_yrs_old	Both	Normal	7762816
Cerebrospinal_Fluid(CSF)	10.0 +/- 6.0	uM	Adult:>18_yrs_old	Both	Normal	HMP Experimental
Cerebrospinal_Fluid(CSF)	8.3 (7.0-13.0)	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Saliva	>10	umol/L	Adult:>18_yrs_old	Both	Normal	12097436
Breast_Milk	116 +/- 22	uM	Adult:>18_yrs_old	N/A	Normal	8839502 


# Concentration_[Abnormal]:
Urine	3.0 (0.0-8.0)	umol/mmol_creatinine	N/A	Both	Lung Cancer	HMP experimental
Cerebrospinal_Fluid(CSF)	170.0 +/- 70.0	uM	Adult:>18_yrs_old	Both	Spina bifida	15681999
Cerebrospinal_Fluid(CSF)	1.46 +/- 0.54	umol/L	Adult:>18_yrs_old	N/A	Vascular Dementia in elderly	15465626
Cerebrospinal_Fluid(CSF)	2.5 +/- 1.0 	umol/L	Elderly:>65_yrs_old	Both	Alzheimer	15465626


# Associated_Disorders:
Alzheimer; Cardiovascular Disease; Lung Adenocarcinoma; Lung Cancer; Spina bifida; Vascular Dementia in elderly

# Pathway_Names:
Glycerophospholipid metabolism;Glycosphingolipid metabolism

# Pathway_Images:
;

# KEGG_Images:
map00564;map00600

# Pathway_Graphs:
;

# Pathway_SBMLs:
;

# Metabolic_Enzyme_1_ID:
5772

# Metabolic_Enzyme_1_Name:
Acetylcholinesterase precursor

# Metabolic_Enzyme_1_Synonyms:
AChE

# Metabolic_Enzyme_1_Gene_Name:
ACHE

# Metabolic_Enzyme_1_Protein_Sequence:
>Acetylcholinesterase precursor
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL

# Metabolic_Enzyme_1_Number_of_Residues:
614

# Metabolic_Enzyme_1_Molecular_Weight:
67797

# Metabolic_Enzyme_1_Theoretical_pI:
6.24

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  cholinesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Rapidly hydrolyzes choline released into the synapse

# Metabolic_Enzyme_1_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_1_Reaction:
acetylcholine + H2O = choline + acetate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF08674:AChE_tetra;
PF00135:COesterase

# Metabolic_Enzyme_1_Signals:
1-31

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.1.1.7

# Metabolic_Enzyme_1_GenBank_ID_Protein:
177975

# Metabolic_Enzyme_1_SwissProt_ID:
ACES_HUMAN (P22303)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ACHE

# Metabolic_Enzyme_1_Geneatlas_id:
ACHE

# Metabolic_Enzyme_1_hgnc_id:
HGNC:108

# Metabolic_Enzyme_1_PDB_ID:
1F8U

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_1_Gene_Sequence:
>1845 bp
ATGAGGCCCCCGCAGTGTCTGCTGCACACGCCTTCCCTGGCTTCCCCACTCCTTCTCCTC
CTCCTCTGGCTCCTGGGTGGAGGAGTGGGGGCTGAGGGCCGGGAGGATGCAGAGCTGCTG
GTGACGGTGCGTGGGGGCCGGCTGCGGGGCATTCGCCTGAAGACCCCCGGGGGCCCTGTC
TCTGCTTTCCTGGGCATCCCCTTTGCGGAGCCACCCATGGGACCCCGTCGCTTTCTGCCA
CCGGAGCCCAAGCAGCCTTGGTCAGGGGTGGTAGACGCTACAACCTTCCAGAGTGTCTGC
TACCAATATGTGGACACCCTATACCCAGGTTTTGAGGGCACCGAGATGTGGAACCCCAAC
CGTGAGCTGAGCGAGGACTGCCTGTACCTCAACGTGTGGACACCATACCCCCGGCCTACA
TCCCCCACCCCTGTCCTCGTCTGGATCTATGGGGGTGGCTTCTACAGTGGGGCCTCCTCC
TTGGACGTGTACGATGGCCGCTTCTTGGTACAGGCCGAGAGGACTGTGCTGGTGTCCATG
AACTACCGGGTGGGAGCCTTTGGCTTCCTGGCCCTGCCGGGGAGCCGAGAGGCCCCGGGC
AATGTGGGTCTCCTGGATCAGAGGCTGGCCCTGCAGTGGGTGCAGGAGAACGTGGCAGCC
TTCGGGGGTGACCCGACATCAGTGACGCTGTTTGGGGAGAGCGCGGGAGCCGCCTCGGTG
GGCATGCACCTGCTGTCCCCGCCCAGCCGGGGCCTGTTCCACAGGGCCGTGCTGCAGAGC
GGTGCCCCCAATGGACCCTGGGCCACGGTGGGCATGGGAGAGGCCCGTCGCAGGGCCACG
CAGCTGGCCCACCTTGTGGGCTGTCCTCCAGGCGGCACTGGTGGGAATGACACAGAGCTG
GTAGCCTGCCTTCGGACACGACCAGCGCAGGTCCTGGTGAACCACGAATGGCACGTGCTG
CCTCAAGAAAGCGTCTTCCGGTTCTCCTTCGTGCCTGTGGTAGATGGAGACTTCCTCAGT
GACACCCCAGAGGCCCTCATCAACGCGGGAGACTTCCACGGCCTGCAGGTGCTGGTGGGT
GTGGTGAAGGATGAGGGCTCGTATTTTCTGGTTTACGGGGCCCCAGGCTTCAGCAAAGAC
AACGAGTCTCTCATCAGCCGGGCCGAGTTCCTGGCCGGGGTGCGGGTCGGGGTTCCCCAG
GTAAGTGACCTGGCAGCCGAGGCTGTGGTCCTGCATTACACAGACTGGCTGCATCCCGAG
GACCCGGCACGCCTGAGGGAGGCCCTGAGCGATGTGGTGGGCGACCACAATGTCGTGTGC
CCCGTGGCCCAGCTGGCTGGGCGACTGGCTGCCCAGGGTGCCCGGGTCTACGCCTACGTC
TTTGAACACCGTGCTTCCACGCTCTCCTGGCCCCTGTGGATGGGGGTGCCCCACGGCTAC
GAGATCGAGTTCATCTTTGGGATCCCCCTGGACCCCTCTCGAAACTACACGGCAGAGGAG
AAAATCTTCGCCCAGCGACTGATGCGATACTGGGCCAACTTTGCCCGCACAGGGGATCCC
AATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAG
TACGTTAGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGC
GCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCCACCGACACGCTCGACGAGGCG
GAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAAC
CAGTTCGACCACTACAGCAAGCAGGATCGCTGCTCAGACCTGTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M55040

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_1_Locus:
7q22

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
2263619; 12853948; 11239002; 8299725; 2714437; 1748670; 1517212; 9640563; 11053835; 8488842

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6055

# Metabolic_Enzyme_2_Name:
Sphingomyelin phosphodiesterase precursor

# Metabolic_Enzyme_2_Synonyms:
Acid sphingomyelinase; aSMase

# Metabolic_Enzyme_2_Gene_Name:
SMPD1

# Metabolic_Enzyme_2_Protein_Sequence:
>Sphingomyelin phosphodiesterase precursor
MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALSDSRVLWAPAEAH
PLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLC
NLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPT
VPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPG
AGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVT
ALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRT
LRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKV
HIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAF
LAPSATTYIGLNPGYRVYQIDGNYSRSSHVVLDHETYILNLTQANIPGAIPHWQLLYRAR
ETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSAR
ADSPALCRHLMPDGSLPEAQSLWPRPLFC

# Metabolic_Enzyme_2_Number_of_Residues:
629

# Metabolic_Enzyme_2_Molecular_Weight:
69852

# Metabolic_Enzyme_2_Theoretical_pI:
7.42

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  sphingomyelin phosphodiesterase activity
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  phospholipid metabolism
Process:  sphingomyelin metabolism
Process:  sphingomyelin catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Converts sphingomyelin to ceramide. aSM also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol

# Metabolic_Enzyme_2_Pathway:
map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_2_Reaction:
sphingomyelin + H2O = N-acylsphingosine + choline phosphate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00149:Metallophos

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
25-47

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.1.4.12

# Metabolic_Enzyme_2_GenBank_ID_Protein:
179095

# Metabolic_Enzyme_2_SwissProt_ID:
ASM_HUMAN (P17405)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
SMPD1

# Metabolic_Enzyme_2_Geneatlas_id:
SMPD1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:11120

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_2_Gene_Sequence:
>1890 bp
ATGCCCCGCTACGGAGCGTCACTCCGCCAGAGCTGCCCCAGGTCCGGCCGGGAGCAGGGA
CAAGACGGGACCGCCGGAGCCCCCGGACTCCTTTGGATGGGCCTGGTGCTGGCGCTGGCG
CTGGCGCTGGCGCTGGCTCTGTCTGACTCTCGGGTTCTCTGGGCTCCGGCAGAGGCTCAC
CCTCTTTCTCCCCAAGGCCATCCTGCCAGGTTACATCGCATAGTGCCCCGGCTCCGAGAT
GTCTTTGGGTGGGGGAACCTCACCTGCCCAATCTGCAAAGGTCTATTCACCGCCATCAAC
CTCGGGCTGAAGAAGGAACCCAATGTGGCTCGCGTGGGCTCCGTGGCCATCAAGCTGTGC
AATCTGCTGAAGATAGCACCACCTGCCGTGTGCCAATCCATTGTCCACCTCTTTGAGGAT
GACATGGTGGAGGTGTGGAGACGCTCAGTGCTGAGCCCATCTGAGGCCTGTGGCCTGCTC
CTGGGCTCCACCTGTGGGCACTGGGACATTTTCTCATCTTGGAACATCTCTTTGCCTACT
GTGCCGAAGCCGCCCCCCAAACCCCCTAGCCCCCCAGCCCCAGGTGCCCCTGTCAGCCGC
ATCCTCTTCCTCACTGACCTGCACTGGGATCATGACTACCTGGAGGGCACGGACCCTGAC
TGTGCAGACCCACTGTGCTGCCGCCGGGGTTCTGGCCTGCCGCCCGCATCCCGGCCAGGT
GCCGGATACTGGGGCGAATACAGCAAGTGTGACCTGCCCCTGAGGACCCTGGAGAGCCTG
TTGAGTGGGCTGGGCCCAGCCGGCCCTTTTGATATGGTGTACTGGACAGGAGACATCCCC
GCACATGATGTCTGGCACCAGACTCGTCAGGACCAACTGCGGGCCCTGACCACCGTCACA
GCACTTGTGAGGAAGTTCCTGGGGCCAGTGCCAGTGTACCCTGCTGTGGGTAACCATGAA
AGCATACCTGTCAATAGCTTCCCTCCCCCCTTCATTGAGGGCAACCACTCCTCCCGCTGG
CTCTATGAAGCGATGGCCAAGGCTTGGGAGCCCTGGCTGCCTGCCGAAGCCCTGCGCACC
CTCAGAATTGGGGGGTTCTATGCTCTTTCCCCATACCCCGGTCTCCGCCTCATCTCTCTC
AATATGAATTTTTGTTCCCGTGAGAACTTCTGGCTCTTGATCAACTCCACGGATCCCGCA
GGACAGCTCCAGTGGCTGGTGGGGGAGCTTCAGGCTGCTGAGGATCGAGGAGACAAAGTG
CATATAATTGGCCACATTCCCCCAGGGCACTGTCTGAAGAGCTGGAGCTGGAATTATTAC
CGAATTGTAGCCAGGTATGAGAACACCCTGGCTGCTCAGTTCTTTGGCCACACTCATGTG
GATGAATTTGAGGTCTTCTATGATGAAGAGACTCTGAGCCGGCCGCTGGCTGTAGCCTTC
CTGGCACCCAGTGCAACTACCTACATCGGCCTTAATCCTGGTTACCGTGTGTACCAAATA
GATGGAAACTACTCCAGGAGCTCTCACGTGGTCCTGGACCATGAGACCTACATCCTGAAT
CTGACCCAGGCAAACATACCGGGAGCCATACCGCACTGGCAGCTTCTCTACAGGGCTCGA
GAAACCTATGGGCTGCCCAACACACTGCCTACCGCCTGGCACAACCTGGTATATCGCATG
CGGGGCGACATGCAACTTTTCCAGACCTTCTGGTTTCTCTACCATAAGGGCCACCCACCC
TCGGAGCCCTGTGGCACGCCCTGCCGTCTGGCTACTCTTTGTGCCCAGCTCTCTGCCCGT
GCTGACAGCCCTGCTCTGTGCCGCCACCTGATGCCAGATGGGAGCCTCCCAGAGGCCCAG
AGCCTGTGGCCAAGGCCACTGTTTTGCTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M59916

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_2_Locus:
11p15.4-p15.1

# Metabolic_Enzyme_2_SNPs:
rs1050239; rs1050228; rs7951904; rs2682091; rs11601088; rs7103750; rs2682090; rs11040883; rs1542705; rs2723661; rs2723660; rs12575136; rs1803161; rs35785620; rs2723669; rs2634197; rs35122256; rs35475253; rs35824453; rs11544727; rs1050233; rs35933246; rs11544728; rs35098198; rs34555120; rs12284348; rs12785962; rs10524555; rs12284355; rs12284353; rs11040884; rs12282823; rs10590511; rs11040885; rs2723659; rs1042983; rs1042996; rs11040886; rs11040887; rs11604636; rs12273714; rs12791308; rs1800424; rs1800425; rs1800426; rs1800606; rs1803158; rs1803159; rs1803160; rs2075583; rs2682092; rs2682093; rs2723629; rs2723633; rs2723646; rs2723656; rs34466697; rs3937838; rs4758415; rs7119910; rs760094; rs760095; rs8164; rs901931

# Metabolic_Enzyme_2_General_References:
1840600; 1292508; 1740330; 8407868; 2555181; 9030779; 12631268; 1718266; 2023926; 1885770; 1391960; 1301192; 1618760; 8051942; 8680412; 8693491; 8664904; 12369017; 12556236

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5254

# Metabolic_Enzyme_3_Name:
Choline O-acetyltransferase

# Metabolic_Enzyme_3_Synonyms:
CHOACTase; Choline acetylase; ChAT

# Metabolic_Enzyme_3_Gene_Name:
CHAT

# Metabolic_Enzyme_3_Protein_Sequence:
>Choline Oacetyltransferase
MGLRTAKKRGLGGGGKWKREEGGGTRGRREVRPACFLQSGGRGDPGDVGGPAGNPGCSPH
PRAATRPPPLPAHTPAHTPEWCGAASAEAAEPRRAGPHLCIPAPGLTKTPILEKVPRKMA
AKTPSSEESGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQ
QKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLIS
GVLSYKALLDSHSIPTDCAKGQLSGQPLCMKQYYGLFSSYRLPGHTQDTLVAQNSSIMPE
PEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNEDERLPPIGLLTSDGRSE
WAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANR
WYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMTQSSRKLIRADSVSELPAP
RRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQ
LAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLL
KDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCKELPEMFMDETYLMSNRFVLSTSQV
PTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCKETSSSKFAKAVEESLIDMRD
LCSLLPPTESKPLATKEKATRPSQGHQP

# Metabolic_Enzyme_3_Number_of_Residues:
748

# Metabolic_Enzyme_3_Molecular_Weight:
82569

# Metabolic_Enzyme_3_Theoretical_pI:
8.69

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses

# Metabolic_Enzyme_3_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_3_Reaction:
acetyl-CoA + choline = CoA + O-acetylcholine

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00755:Carn_acyltransf

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.3.1.6

# Metabolic_Enzyme_3_GenBank_ID_Protein:
301096

# Metabolic_Enzyme_3_SwissProt_ID:
CLAT_HUMAN (P28329)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
CHAT

# Metabolic_Enzyme_3_Geneatlas_id:
CHAT

# Metabolic_Enzyme_3_hgnc_id:
HGNC:1912

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>2247 bp
ATGGGGCTGAGGACAGCGAAGAAGAGGGGGCTTGGGGGAGGGGGGAAATGGAAGAGAGAG
GAGGGAGGAGGTACAAGAGGAAGGAGAGAAGTGCGGCCAGCTTGCTTTCTCCAGTCGGGT
GGCCGCGGGGACCCGGGCGACGTCGGAGGCCCTGCCGGGAACCCAGGCTGCAGCCCCCAC
CCCCGCGCTGCGACACGCCCCCCACCCCTTCCGGCTCACACCCCCGCCCACACTCCTGAG
TGGTGCGGTGCAGCGTCGGCCGAGGCAGCAGAGCCGAGGAGAGCAGGTCCACACCTCTGC
ATCCCTGCACCAGGACTCACCAAGACGCCCATCCTGGAAAAGGTCCCCCGTAAGATGGCA
GCAAAAACTCCCAGCAGTGAGGAGTCTGGGCTGCCCAAACTGCCCGTGCCCCCGCTGCAG
CAGACCCTGGCCACGTACCTGCAGTGCATGCGACACTTGGTGTCTGAGGAGCAGTTCAGG
AAGAGCCAGGCCATTGTGCAGCAGTTTGGGGCCCCTGGTGGCCTCGGCGAGACCCTGCAG
CAGAAACTCCTGGAGCGGCAGGAGAAGACAGCCAACTGGGTGTCTGAGTACTGGCTGAAT
GACATGTATCTCAACAACCGCCTGGCCCTGCCTGTCAACTCCAGCCCTGCCGTGATCTTT
GCTCGGCAGCACTTCCCTGGCACCGATGACCAGCTGAGGTTTGCAGCCAGCCTCATCTCT
GGTGTACTCAGCTACAAGGCCCTGCTGGACAGCCACTCCATTCCCACTGACTGTGCCAAA
CCGGAGCTGTCAGGGCAGCCCCTTTGCATGAAGCAATACTATGGGCTCTTCTCCTCCTAC
CGGCTCCCCGGCCATACCCAGGACACGCTGGTGGCTCAGAACAGCAGCATCATGCCGGAG
CCTGAGCACGTCATCGTAGCCTGCTGCAATCAGTTCTTTGTCTTGGATGTTGTCATTAAT
TTCCGCCGTCTCAGTGAGGGGGATCTGTTCACTCAGTTGAGAAAGATAGTCAAAATGGCT
TCCAACGAGGACGAGCGTTTGCCTCCAATTGGCCTGCTGACGTCTGACGGGAGGAGCGAG
TGGGCCGAGGCCAGGACGGTCCTCGTGAAAGACTCCACCAACCGGGACTCGCTGGACATG
ATTGAGCGCTGCATCTGCCTTGTATGCCTGGACGGCCCAGGAGGCGTGGAGCTCAGCGAC
ACCCACAGGGCACTCCAGCTCCTTCACGGCGGAGGCTACAGCAAGAACGGGGCCAATCGC
TGGTACGACAAGTCCCTGCAGTTTGTGGTGGGCCGAGACGCGACCTGCGGTGTGGTGTGC
GAACACTCCCCATTCGATGGCATCGTCCTGGTGCAGTGCACTGAGCATCTGCTCAAGCAC
ATGACGCAGAGCAGCAGGAAGCTGATCCGAGCAGACTCCGTCAGCGAGCTCCCCGCCCCC
CGGAGGCTGCGGTGGAAATGCTCCCCGGAAATTCAAGGCCACTTAGCCTCCTCGGCAGAA
AAACTTCAACGAATAGTAAAGAACCTTGACTTCATTGTCTATAAGTTTGACAACTATGGG
AAAACATTCATTAAGAAGCAGAAATGCAGCCCTGATGCCTTCATCCAGGTGGCCCTCCAG
CTGGCCTTCTACAGGCTCCACCGAAGACTGGTGCCCACCTACGAGAGCGCGTCCATCCGC
CGATTCCAGGAGGGACGCGTGGACAACATCAGATCGGCCACTCCAGAGGCACTGGCTTTT
GTGAGAGCCGTGACTGACCACAAGGCTGCTGTGCCAGCTTCTGAGAAGCTTCTGCTCCTG
AAGGATGCCATCCGTGCCCAGACTGCATACACAGTCATGGCCATAACAGGGATGGCCATT
GACAACCACCTGCTGGCACTGCGGGAGCTGGCCCGGGCCATGTGCAAGGAGCTGCCCGAG
ATGTTCATGGATGAAACCTACCTGATGAGCAACCGGTTTGTCCTCTCCACTAGCCAGGTG
CCCACAACCACGGAGATGTTCTGCTGCTATGGTCCTGTGGTCCCAAATGGGTATGGTGCC
TGCTACAACCCCCAGCCAGAGACCATCCTTTTCTGCATCTCTAGCTTTCACAGCTGCAAA
GAGACTTCTTCTAGCAAGTTTGCAAAAGCTGTGGAAGAAAGCCTCATTGACATGAGAGAC
CTCTGCAGTCTGCTGCCGCCTACTGAGAGCAAGCCATTGGCAACAAAGGAAAAAGCCACG
AGGCCCAGCCAGGGACACCAACCTTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
S56138

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
1337937; 11172068; 1388731; 1339386; 1784419

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5309

# Metabolic_Enzyme_4_Name:
Phospholipase D2

# Metabolic_Enzyme_4_Synonyms:
PLD 2; Choline phosphatase 2; Phosphatidylcholine-hydrolyzing phospholipase D2; PLD1C; hPLD2

# Metabolic_Enzyme_4_Gene_Name:
PLD2

# Metabolic_Enzyme_4_Protein_Sequence:
>Phospholipase D2
MTATPESLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQSLKVHPLVFA
PGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVL
MSLLPLARFAVAYSPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYR
NYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVV
KDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSLILKCSSYRQAR
WWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIF
ITDWWLSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRAL
MLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSSE
SAASQPPTPRPDSPATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPW
RDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKSTSTANQLPFTLPGGQ
CTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDE
IVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHR
LKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTVIIGSANINDRSLL
GKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILGANTRPDLDLRDPICD
DFFQLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQ
GHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT

# Metabolic_Enzyme_4_Number_of_Residues:
933

# Metabolic_Enzyme_4_Molecular_Weight:
105988

# Metabolic_Enzyme_4_Theoretical_pI:
7.68

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
May have a role in signal-induced cytoskeletal regulation and/or endocytosis

# Metabolic_Enzyme_4_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_4_Reaction:
A phosphatidylcholine + H2O = choline + a phosphatidate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00169:PH;
PF00614:PLDc;
PF00787:PX

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.1.4.4

# Metabolic_Enzyme_4_GenBank_ID_Protein:
2645858

# Metabolic_Enzyme_4_SwissProt_ID:
PLD2_HUMAN (O14939)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
PLD2

# Metabolic_Enzyme_4_Geneatlas_id:
PLD2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:9068

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Membrane; peripheral membrane protein

# Metabolic_Enzyme_4_Gene_Sequence:
>2802 bp
ATGACGGCGACCCCTGAGAGCCTCTTCCCCACTGGGGACGAACTGGACTCCAGCCAGCTC
CAGATGGAGTCCGATGAGGTGGACACCCTGAAGGAGGGAGAGGACCCAGCCGACCGGATG
CACCCGTTTCTGGCCATCTATGAGCTTCAGTCTCTGAAAGTGCACCCCTTGGTGTTCGCA
CCTGGGGTCCCTGTCACAGCCCAGGTGGTGGGCACCGAAAGATATACCAGCGGATCCAAG
GTGGGAACCTGCACTCTGTATTCTGTCCGCTTGACTCACGGCGACTTTTCCTGGACAACC
AAGAAGAAATACCGTCATTTTCAGGAGCTGCATCGGGACCTCCTGAGACACAAAGTCTTG
ATGAGTCTGCTCCCTCTGGCTCGATTTGCCGTTGCCTATTCTCCAGCCCGAGATGCAGGC
AACAGAGAGATGCCCTCTCTACCCCGGGCAGGTCCTGAGGGCTCCACCAGACATGCAGCC
AGCAAACAGAAATACCTGGAGAATTACCTCAACTGTCTCTTGACCATGTCTTTCTATCGC
AACTACCATGCCATGACAGAGTTCCTGGAAGTCAGTCAGCTGTCCTTTATCCCGGACTTG
GGCCGCAAAGGACTGGAGGGGATGATCCGGAAGCGCTCAGGTGGCCACCGTGTTCCTGGC
CTCACCTGCTGTGGCCGAGACCAAGTTTGTTATCGCTGGTCCAAGAGGTGGCTGGTGGTG
AAGGACTCCTTCCTGCTGTACATGTGCCTCGAGACAGGTGCCATCTCATTTGTTCAGCTC
TTTGACCCTGGCTTTGAGGTGCAAGTGGGGAAAAGGAGCACGGAGGCACGGCACGGCGTG
CGGATCGATACCTCCCACAGGTCCTTGATTCTCAAGTGCAGCAGCTACCGGCAGGCACGG
TGGTGGGCCCAAGAGATCACTGAGCTGGCACAGGGCCCAGGCAGAGACTTCCTACAGCTG
CACCGGCATGACAGCTACGCCCCACCCCGGCCTGGGACCTTGGCCCGGTGGTTTGTGAAT
GGGGCAGGTTACTTTGCTGCTGTGGCAGATGCCATCCTTCGAGCTCAAGAGGAGATTTTC
ATCACAGACTGGTGGTTGAGTCCTGAGGTTTACCTGAAGCGTCCGGCCCATTCAGATGAC
TGGAGACTGGACATTATGCTCAAGAGGAAGGCGGAGGAAGGTGTCCGTGTGTCTATTCTG
CTGTTTAAAGAAGTGGAATTGGCCTTGGGCATCAACAGTGGCTATAGCAAGAGGGCGCTG
ATGCTGCTGCACCCCAACATAAAGGTGATGCGTCACCCAGACCAAGTGACGTTGTGGGCC
CATCATGAGAAGCTCCTGGTGGTGGACCAAGTGGTAGCATTCCTGGGGGGACTGGACCTT
GCCTATGGCCGCTGGGATGACCTGCACTACCGACTGACTGACCTTGGAGACTCCTCTGAA
TCAGCTGCCTCCCAGCCTCCCACCCCGCGCCCAGACTCACCAGCCACCCCAGACCTCTCT
CACAACCAATTCTTCTGGCTGGGCAAGGACTACAGCAATCTTATCACCAAGGACTGGGTG
CAGCTGGACCGGCCTTTCGAAGATTTCATTGACAGGGAGACGACCCCTCGGATGCCATGG
CGGGACGTTGGGGTGGTCGTCCATGGCCTACCGGCCCGGGACCTTGCCCGGCACTTCATC
CAGCGCTGGAACTTCACCAAGACCACCAAGGCCAAGTACAAGACTCCCACATACCCCTAC
CTGCTTCCCAAGTCTACCAGCACGGCCAATCAGCTCCCCTTCACACTTCCAGGAGGGCAG
TGCACCACCGTACAGGTCTTGCGATCAGTGGACCGCTGGTCAGCAGGGACTCTGGAGAAC
TCCATCCTCAATGCCTACCTGCACACCATCAGGGAGAGCCAGCACTTCCTCTACATTGAG
AATCAGTTCTTCATTAGCTGCTCAGATGGGCGGACGGTTCTGAACAAGGTGGGCGATGAG
ATTGTGGACAGAATCCTGAAGGCCCACAAACAGGGGTGGTGTTACCGAGTCTACGTGCTT
TTGCCCTTACTCCCTGGCTTCGAGGGTGACATCTCCACGGGCGGTGGCAACTCCATCCAG
GCCATTCTGCACTTTACTTACAGGACCCTGTGTCGTGGGGAGTATTCAATCCTGCATCGC
CTTAAAGCAGCCATGGGGACAGCATGGCGGGACTATATTTCCATCTGCGGGCTTCGTACA
CACGGAGAGCTGGGCGGGCACCCCGTCTCGGAGCTCATCTACATCCACAGCAAGGTGCTC
ATCGCAGATGACCGGACAGTCATCATTGGTTCTGCAAACATCAATGACCGGAGCTTGCTG
GGGAAGCGGGACAGTGAGCTGGCCGTGCTGATCGAGGACACAGAGACGGAACCATCCCTC
ATGAATGGGGCAGAGTATCAGGCGGGCAGGTTTGCCTTGAGTCTGCGGAAGCACTGCTTC
GGTGTGATTCTTGGAGCAAATACCCGGCCAGACTTGGATCTCCGAGACCCCATCTGTGAT
GACTTCTTCCAGTTGTGGCAAGACATGGCTGAGAGCAACGCCAATATCTATGAGCAGATC
TTCCGCTGCCTGCCATCCAATGCCACGCGTTCCCTGCGGACTCTCCGGGAGTACGTGGCC
GTGGAGCCCTTGGCCACGGTCAGTCCCCCCTTGGCTCGGTCTGAGCTCACCCAGGTCCAG
GGCCACCTGGTCCACTTCCCCCTCAAGTTCCTAGAGGATGAGTCTTTGCTGCCCCCGCTG
GGTAGCAAGGAGGGCATGATCCCCCTAGAAGTGTGGACATAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF033850

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_4_Locus:
17p13.1

# Metabolic_Enzyme_4_SNPs:
rs3764897; rs1052748; rs2286672; rs1052751; rs7211943; rs1132448; rs3867173; rs7212512; rs2875840; rs3764899; rs2286671; rs11078539; rs6502824; rs3853646; rs2302327; rs2302325; rs3764900; rs2875841; rs11656427; rs2286670; rs3786043; rs11658292; rs11658287; rs3786041; rs4790233; rs4790709; rs12936266; rs2302326; rs3888339; rs4790234; rs4566240; rs17854914; rs2302323; rs11545163; rs1132447; rs1052746; rs3178169; rs1052742; rs3081358; rs35439858; rs1052779; rs35937990; rs5818989; rs36231931; rs2875842; rs36229113; rs5818990; rs1052755; rs34361510; rs35608631; rs3786042; rs35190261; rs35037094; rs3081314; rs3889229; rs2286669; rs7212717; rs28585446; rs9635707; rs2302324; rs2326097; rs35472015; rs2326088; rs7213994; rs35410162; rs34011348; rs12452111; rs9635706; rs2326098; rs3835027; rs3841515; rs9635705; rs34698829; rs34336549; rs34834883; rs2326087; rs4790707; rs34921470; rs35305168; rs1050296; rs11654671; rs11654690; rs12453110; rs1804248; rs2304974; rs2304975; rs4053369; rs4053373; rs7468

# Metabolic_Enzyme_4_General_References:
9761774; 9582313

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5311

# Metabolic_Enzyme_5_Name:
Phospholipase D1

# Metabolic_Enzyme_5_Synonyms:
PLD 1; Choline phosphatase 1; Phosphatidylcholine-hydrolyzing phospholipase D1; hPLD1

# Metabolic_Enzyme_5_Gene_Name:
PLD1

# Metabolic_Enzyme_5_Protein_Sequence:
>Phospholipase D1
MSLKNEPRVNTSALQKIAADMSNIIENLDTRELHFEGEEVDYDVSPSDPKIQEVYIPFSA
IYNTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTTRVPSINLYTIELTHGEFKWQVKRKF
KHFQEFHRELLKYKAFIRIPIPTRRHTFRRQNVREEPREMPSLPRSSENMIREEQFLGRR
KQLEDYLTKILKMPMYRNYHATTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNC
CGQGRACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRID
NLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENALAKWYVNAKG
YFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLY
KEVELALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGI
DLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLKDKNEPVQNLPIQKS
IDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGL
KPHFKLFHPSSESEQGLTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQL
DKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLL
PKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIE
NQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQ
AIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLL
IADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCF
RVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFI
NKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLLPSVGTKEAIVPMEVWT

# Metabolic_Enzyme_5_Number_of_Residues:
1074

# Metabolic_Enzyme_5_Molecular_Weight:
124186

# Metabolic_Enzyme_5_Theoretical_pI:
9.07

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic

# Metabolic_Enzyme_5_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_5_Reaction:
A phosphatidylcholine + H2O = choline + a phosphatidate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00169:PH;
PF00614:PLDc;
PF00787:PX

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.1.4.4

# Metabolic_Enzyme_5_GenBank_ID_Protein:
1185463

# Metabolic_Enzyme_5_SwissProt_ID:
PLD1_HUMAN (Q13393)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
PLD1

# Metabolic_Enzyme_5_Geneatlas_id:
PLD1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:9067

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm; perinuclear region. Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity). Endosome; late endosome (By similarity)

# Metabolic_Enzyme_5_Gene_Sequence:
>3225 bp
ATGTCACTGAAAAACGAGCCACGGGTAAATACCTCTGCACTGCAGAAAATTGCTGCTGAC
ATGAGTAATATCATAGAAAATCTGGACACGCGGGAACTCCACTTTGAGGGAGAGGAGGTA
GACTACGACGTGTCTCCCAGCGATCCCAAGATACAAGAAGTGTATATCCCTTTCTCTGCT
ATTTATAACACTCAAGGATTTAAGGAGCCTAATATACAGACGTATCTCTCCGGCTGTCCA
ATAAAAGCACAAGTTCTGGAAGTGGAACGCTTCACATCTACAACAAGGGTACCAAGTATT
AATCTTTACACTATTGAATTAACACATGGGGAATTTAAATGGCAAGTTAAGAGGAAATTC
AAGCATTTTCAAGAATTTCACAGAGAGCTGCTCAAGTACAAAGCCTTTATCCGCATCCCC
ATTCCCACTAGAAGACACACGTTTAGGAGGCAAAACGTCAGAGAGGAGCCTCGAGAGATG
CCCAGTTTGCCCCGTTCATCTGAAAACATGATAAGAGAAGAACAATTCCTTGGTAGAAGA
AAACAACTGGAAGATTACTTGACAAAGATACTAAAAATGCCCATGTATAGAAACTATCAT
GCCACAACAGAGTTTCTTGATATAAGCCAGCTGTCTTTCATCCATGATTTGGGACCAAAG
GGCATAGAAGGTATGATAATGAAAAGATCTGGAGGACACAGAATACCAGGCTTGAATTGC
TGTGGTCAGGGAAGAGCCTGCTACAGATGGTCAAAAAGATGGTTAATAGTGAAAGATTCC
TTTTTATTGTATATGAAACCAGACAGCGGTGCCATTGCCTTCGTCCTGCTGGTAGACAAA
GAATTCAAAATTAAGGTGGGGAAGAAGGAGACAGAAACGAAATATGGAATCCGAATTGAT
AATCTTTCAAGGACACTTATTTTAAAATGCAACAGCTATAGACATGCTCGGTGGTGGGGA
GGGGCTATAGAAGAATTCATCCAGAAACATGGCACCAACTTTCTCAAAGATCATCGATTT
GGGTCATATGCTGCTATCCAAGAGAATGCTTTAGCTAAATGGTATGTTAATGCCAAAGGA
TATTTTGAAGATGTGGCAAATGCAATGGAAGAGGCAAATGAAGAGATTTTTATCACAGAC
TGGTGGCTGAGTCCAGAAATCTTCCTGAAACGCCCAGTGGTTGAGGGAAATCGTTGGAGG
TTGGACTGCATTCTTAAACGAAAAGCACAACAAGGAGTGAGGATCTTCATAATGCTCTAC
AAAGAGGTGGAACTCGCTCTTGGCATCAATAGTGAATACACCAAGAGGACTTTGATGCGT
CTACATCCCAACATAAAGGTGATGAGACACCCGGATCATGTGTCATCCACCGTCTATTTG
TGGGCTCACCATGAGAAGCTTGTCATCATTGACCAATCGGTGGCCTTTGTGGGAGGGATT
GACCTGGCCTATGGAAGGTGGGACGACAATGAGCACAGACTCACAGACGTGGGCAGTGTG
AAGCGGGTCACTTCAGGACCGTCTCTGGGTTCCCTCCCACCTGCCGCAATGGAGTCTATG
GAATCCTTAAGACTCAAAGATAAAAATGAGCCTGTTCAAAACCTACCCATCCAGAAGAGT
ATTGATGATGTGGATTCAAAACTGAAAGGAATAGGAAAGCCAAGAAAGTTCTCCAAATTT
AGTCTCTACAAGCAGCTCCACAGGCACCACCTGCACGACGCAGATAGCATCAGCAGCATT
GACAGCACCTCCAGTTATTTTAATCACTATAGAAGTCATCACAATTTAATCCATGGTTTA
AAACCCCACTTCAAACTCTTTCACCCGTCCAGTGAGTCTGAGCAAGGACTCACTAGACCT
CATGCTGATACCGGGTCCATCCGTAGTTTACAGACAGGTGTGGGAGAGCTGCATGGGGAA
ACCAGATTCTGGCATGGAAAGGACTACTGCAATTTCGTCTTCAAAGACTGGGTTCAACTT
GATAAACCTTTTGCTGATTTCATTGACAGGTACTCCACGCCCCGGATGCCCTGGCATGAC
ATTGCCTCTGCAGTCCACGGGAAGGCGGCTCGTGATGTGGCACGTCACTTCATCCAGCGC
TGGAACTTCACAAAAATTATGAAATCAAAATATCGGTCCCTTTCTTATCCTTTTCTGCTT
CCAAAGTCTCAAACAACAGCCCATGAGTTGAGATATCAAGTGCCTGGGTCTGTCCATGCT
AACGTACAGTTGCTCCGCTCTGCTGCTGATTGGTCTGCTGGTATAAAGTACCATGAAGAG
TCCATCCACGCCGCTTACGTCCATGTGATAGAGAACAGCAGGCACTATATCTATATCGAA
AACCAGTTTTTCATAAGCTGTGCTGATGACAAAGTTGTGTTCAACAAGATAGGCGATGCC
ATTGCCCAGAGGATCCTGAAAGCTCACAGGGAAAACCAGAAATACCGGGTATATGTCGTG
ATACCACTTCTGCCAGGGTTCGAAGGAGACATTTCAACCGGCGGAGGAAATGCTCTACAG
GCAATCATGCACTTCAACTACAGAACCATGTGCAGAGGAGAAAATTCCATCCTTGGACAG
TTAAAAGCAGAGCTTGGTAATCAGTGGATAAATTACATATCATTCTGTGGTCTTAGAACA
CATGCAGAGCTCGAAGGAAACCTAGTAACTGAGCTTATCTATGTCCACAGCAAGTTGTTA
ATTGCTGATGATAACACTGTTATTATTGGCTCTGCCAACATAAATGACCGCAGCATGCTG
GGAAAGCGTGACAGTGAAATGGCTGTCATTGTGCAAGATACAGAGACTGTTCCTTCAGTA
ATGGATGGAAAAGAGTACCAAGCTGGCCGGTTTGCCCGAGGACTTCGGCTACAGTGCTTT
AGGGTTGTCCTTGGCTATCTTGATGACCCAAGTGAGGACATTCAGGATCCAGTGAGTGAC
AAATTCTTCAAGGAGGTGTGGGTTTCAACAGCAGCTCGAAATGCTACAATTTATGACAAG
GTTTTCCGGTGCCTTCCCAATGATGAAGTACACAATTTAATTCAGCTGAGAGACTTTATA
AACAAGCCCGTATTAGCTAAGGAAGATCCCATTCGAGCTGAGGAGGAACTGAAGAAGATC
CGTGGATTTTTGGTGCAATTCCCCTTTTATTTCTTGTCTGAAGAAAGCCTACTGCCTTCT
GTTGGGACCAAAGAGGCCATAGTGCCCATGGAGGTTTGGACTTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U38545

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_5_Locus:
3q26

# Metabolic_Enzyme_5_SNPs:
rs9819927; rs2290480; rs9827333; rs2287579; rs9881788; rs6766336; rs2124147; rs9821754; rs9822322; rs1473377; rs1869648; rs1563262; rs2168205; rs754051; rs1454903; rs2178533; rs4894497; rs4131285; rs6809327; rs4894755; rs10936697; rs4256166; rs9838510; rs6445019; rs6790634; rs7610093; rs2422375; rs9866473; rs6445020; rs7635025; rs1869647; rs4894499; rs1902139; rs6791758; rs7647840; rs2305548; rs9290424; rs7631698; rs6445024; rs6781814; rs7643183; rs7634685; rs1882256; rs6798723; rs7616441; rs7620136; rs6445009; rs3774034; rs6764162; rs7611425; rs1563261; rs12632647; rs9290426; rs3774033; rs1921345; rs4894760; rs1882257; rs6445018; rs3774041; rs4582082; rs6809647; rs4131284; rs6763711; rs9290428; rs6807121; rs9882641; rs4894504; rs2061064; rs6781809; rs6445023; rs6445017; rs4894495; rs9835318; rs9290423; rs9810450; rs4894742; rs7616376; rs6445010; rs2901726; rs11718550; rs9859424; rs11714365; rs9846460; rs4894493; rs3774045; rs4894740; rs6769286; rs6445015; rs4894728; rs7618276; rs1392208; rs4894754; rs10936699; rs9828579; rs11712503; rs4243417; rs4894743; rs360408; rs2290479; rs1378242; rs6809419; rs9836954; rs6794587; rs4894492; rs9863761; rs6771343; rs2276794; rs2422377; rs1921344; rs9831491; rs9836712; rs6761990; rs7626797; rs12491008; rs9985447; rs7652359; rs4894490; rs4894707; rs6805911; rs10755128; rs7624560; rs9850783; rs6445011; rs7632685; rs7624044; rs7620874; rs7616430; rs7619079; rs7620815; rs10513698; rs6794795; rs16856569; rs6788652; rs7614707; rs7618750; rs3774039; rs7616361; rs4131283; rs7622276; rs9290432; rs6445013; rs3774036; rs6806023; rs10936698; rs6797824; rs6793193; rs6806989; rs7612421; rs6805425; rs7649974; rs3774038; rs6781853; rs9290430; rs1076504; rs360399; rs2422376; rs2276793; rs4894753; rs6445016; rs2305547; rs6794454; rs7617044; rs11929621; rs4894750; rs9830433; rs9869963; rs7616760; rs9820542; rs9845959; rs6773632; rs9858001; rs4493457; rs373999; rs7632580; rs7628731; rs9290434; rs9811588; rs9844363; rs9869289; rs9817899; rs4894747; rs9824608; rs6772146; rs9842562; rs35765488; rs6785259; rs6767012; rs9290422; rs13091852; rs16856578; rs9860213; rs17518961; rs416158; rs11917857; rs6764285; rs6774359; rs16856586; rs9823244; rs6445012; rs6782508; rs9832053; rs11720952; rs13323527; rs7632491; rs9862429; rs9818692; rs9818399; rs3774037; rs3774040; rs9855905; rs9818812; rs9869368; rs9818540; rs9880548; rs4894503; rs1454902; rs11916755; rs4894496; rs6783321; rs6773529; rs9829394; rs12635653; rs7433336; rs7638344; rs749481; rs9826766; rs9870809; rs9881676; rs1392209; rs9841075; rs2287577; rs16856581; rs6763933; rs9815257; rs4894494; rs7609750; rs6782049; rs7631356; rs11712311; rs7652569; rs7631869; rs2002006; rs360407; rs1392207; rs7625755; rs9714380; rs7638141; rs7631451; rs9917830; rs9832431; rs9290425; rs4894491; rs13320926; rs9879513; rs4894746; rs7355830; rs4894715; rs9871902; rs6781556; rs4261904; rs6804535; rs13327509; rs35127978; rs9821947; rs34195468; rs1054253; rs9822242; rs36012544; rs35101789; rs35670538; rs13068935; rs35483608; rs34637085; rs28759283; rs2544153; rs34136570; rs360405; rs9871708; rs10613561; rs5854444; rs34942380; rs2045170; rs13321633; rs11378587; rs9860038; rs9880430; rs4568171; rs9838989; rs13323858; rs35006593; rs12107890; rs9810871; rs35851997; rs4600841; rs9883453; rs3961987; rs10663017; rs9852475; rs9847979; rs6770239; rs9837034; rs4894749; rs11360799; rs6791958; rs34774903; rs35874975; rs41273589; rs41273593; rs6786358; rs34772565; rs34781513; rs9870386; rs7649966; rs11278598; rs11425932; rs6798359; rs9881170; rs3836455; rs10575495; rs9812524; rs13062967; rs35255380; rs4616674; rs7426452; rs11372398; rs9851279; rs13317506; rs7652423; rs9864065; rs9858157; rs34475209; rs35659465; rs10704846; rs9828238; rs11929048; rs41273595; rs9858003; rs7429181; rs34047635; rs28642384; rs5854448; rs9863552; rs36230395; rs1823923; rs9863833; rs705025; rs35365001; rs13084373; rs10621695; rs10552176; rs10702797; rs4613482; rs34590693; rs1499849; rs9826758; rs5854439; rs7647033; rs9839428; rs10600843; rs9840146; rs36106956; rs35702864; rs34750843; rs3774042; rs6783520; rs10710862; rs11456805; rs35333974; rs5854445; rs9859130; rs2604103; rs13327893; rs11393886; rs9821786; rs6792460; rs35608149; rs3050412; rs9832151; rs11338168; rs193333; rs10704146; rs9876786; rs35107980; rs35881246; rs11360798; rs731044; rs34366683; rs7432859; rs36082494; rs6796730; rs36068935; rs34786482; rs28711733; rs10702650; rs34463479; rs34861885; rs10594654; rs3214830; rs4449349; rs10663360; rs13088019; rs12107937; rs12638735; rs6792564; rs12631679; rs2544151; rs35406267; rs10619884; rs35965110; rs41273587; rs34045644; rs35032653; rs11319073; rs9851422; rs10625716; rs11359377; rs7630703; rs34976174; rs35452974; rs12633024; rs34667914; rs6803986; rs10684599; rs10621070; rs34526007; rs7632331; rs9814325; rs35601747; rs34921372; rs34815441; rs9871544; rs34904148; rs9871396; rs13068940; rs35759055; rs6781880; rs35888555; rs9290429; rs9864124; rs5854440; rs9851447; rs34234073; rs6788739; rs11391361; rs6774916; rs13079449; rs10620004; rs5854443; rs28375171; rs11372810; rs11299225; rs433586; rs2909557; rs35118621; rs3050415; rs11268323; rs9837314; rs6762792; rs754050; rs13326409; rs9832303; rs33925478; rs11378586; rs1378243; rs12107844; rs9878033; rs10684636; rs13318350; rs2544152; rs9825980; rs3774044; rs5854447; rs34320069; rs10222579; rs9810537; rs35334642; rs36096949; rs7612499; rs10576803; rs34006230; rs28668937; rs35539240; rs7624132; rs7610063; rs12634083; rs6804852; rs360406; rs11310595; rs11401263; rs35085404; rs35848779; rs10704304; rs5854442; rs3821745; rs4894730; rs11706109; rs35055974; rs10621127; rs10703192; rs28407244; rs7429182; rs3050440; rs9858995; rs35382479; rs2287578; rs731043; rs11416324; rs4438685; rs28749915; rs4488867; rs11346342; rs11375259; rs4349528; rs9826593; rs9942046; rs11456818; rs13060859; rs7645352; rs6795501; rs9829798; rs7632869; rs10663361; rs13068911; rs387964; rs34919896; rs9882439; rs11342343; rs9837366; rs9858838; rs1392210; rs34198532; rs4894748; rs35606158; rs35396258; rs11397647; rs35724069; rs34772058; rs34883446; rs10621200; rs1106288; rs9868868; rs28552643; rs11321947; rs9851549; rs9826698; rs35175182; rs6785257; rs34340739; rs10704153; rs28663429; rs41273591; rs34385980; rs11375502; rs7642800; rs12106843; rs35731319; rs9830147; rs9871438; rs34629638; rs35213067; rs4293729; rs4635737; rs35959131; rs11430413; rs11399852; rs11359957; rs10049336; rs7648386; rs189827; rs11420673; rs5854446; rs7355994; rs7624820; rs13318483; rs10619883; rs35982384; rs12107445; rs9824139; rs34132902; rs35961431; rs7644780; rs10561828; rs34441571; rs6768605; rs3050403; rs5854438; rs10614037; rs5854441; rs10936694; rs12631941; rs13063848; rs13326387; rs16856509; rs16856522; rs181715; rs2604101; rs360400; rs360401; rs360402; rs360404; rs4378993; rs4894475; rs4894476; rs6775402; rs6780561; rs6800474; rs6801138; rs6803271; rs6804870; rs7635962; rs83615; rs83616; rs9815479; rs9820941; rs9871488; rs9871646; rs9872171; rs9872527; rs9876839

# Metabolic_Enzyme_5_General_References:
8530346; 9013646; 9761774; 9582313

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
6056

# Metabolic_Enzyme_6_Name:
Choline/ethanolamine kinase [Includes: Choline kinase beta

# Metabolic_Enzyme_6_Synonyms:
CK; Ethanolamine kinase; EK]

# Metabolic_Enzyme_6_Gene_Name:
CHKB

# Metabolic_Enzyme_6_Protein_Sequence:
>Choline/ethanolamine kinase Includes: Choline kinase beta
MAAEATAVAGSGAVGGCLAKDGLQQSKCPDTTPKRRRASSLSRDAERRAYQWCREYLGGA
WRRVQPEELRVYPVSGGLSNLLFRCSLPDHLPSVGEEPREVLLRLYGAILQGVDSLVLES
VMFAILAERSLGPQLYGVFPEGRLEQYIPSRPLKTQELREPVLSAAIATKMAQFHGMEMP
FTKEPHWLFGTMERYLKQIQDLPPTGLPEMNLLEMYSLKDEMGNLRKLLESTPSPVVFCH
NDIQEGNILLLSEPENADSLMLVDFEYSSYNYRGFDIGNHFCEWVYDYTHEEWPFYKARP
TDYPTQEQQLHFIRHYLAEAKKGETLSQEEQRKLEEDLLVEVSRYALASHFFWGLWSILQ
ASMSTIEFGYLDYAQSRFQFYFQQKGQLTSVHSSS

# Metabolic_Enzyme_6_Number_of_Residues:
395

# Metabolic_Enzyme_6_Molecular_Weight:
45272

# Metabolic_Enzyme_6_Theoretical_pI:
5.20

# Metabolic_Enzyme_6_GO_Classification:
Not Available

# Metabolic_Enzyme_6_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_6_Specific_Function:
ATP + choline = ADP + O-phosphocholine

# Metabolic_Enzyme_6_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_6_Reaction:
ATP + ethanolamine = ADP + O-phosphoethanolamine

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF01633:Choline_kinase

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.7.1.32;EC 2.7.1.82

# Metabolic_Enzyme_6_GenBank_ID_Protein:
5509940

# Metabolic_Enzyme_6_SwissProt_ID:
CHKB_HUMAN (Q9Y259)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
CHKB

# Metabolic_Enzyme_6_Geneatlas_id:
CHKB

# Metabolic_Enzyme_6_hgnc_id:
HGNC:1938

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>1188 bp
ATGGCGGCCGAGGCGACAGCTGTGGCCGGAAGCGGGGCTGTTGGCGGCTGCCTGGCCAAA
GACGGCTTGCAGCAGTCTAAGTGCCCGGACACTACCCCAAAACGGCGGCGCGCCTCGTCG
CTGTCGCGTGACGCCGAGCGCCGAGCCTACCAATGGTGCCGGGAGTACTTGGGCGGGGCC
TGGCGCCGAGTGCAGCCCGAGGAGCTGAGGGTTTACCCCGTGAGCGGAGGCCTCAGCAAC
CTGCTCTTCCGCTGCTCGCTCCCGGACCACCTGCCCAGCGTTGGCGAGGAGCCCCGGGAG
GTGCTTCTGCGGCTGTACGGAGCCATCTTGCAGGGCGTGGACTCCCTGGTGCTAGAAAGC
GTGATGTTCGCCATACTTGCGGAGCGGTCGCTGGGGCCCCAGCTGTACGGAGTCTTCCCA
GAGGGCCGGCTGGAACAGTACATCCCAAGTCGGCCATTGAAAACTCAAGAGCTTCGAGAG
CCAGTGTTGTCAGCAGCCATTGCCACGAAGATGGCGCAATTTCATGGCATGGAGATGCCT
TTCACCAAGGAGCCCCACTGGCTGTTTGGGACCATGGAGCGGTACCTAAAACAGATCCAG
GACCTGCCCCCAACTGGCCTCCCTGAGATGAACCTGCTGGAGATGTACAGCCTGAAGGAT
GAGATGGGCAACCTCAGGAAGTTACTAGAGTCTACCCCATCGCCAGTCGTCTTCTGCCAC
AATGACATCCAGGAAGGGAACATCTTGCTGCTCTCAGAGCCAGAAAATGCTGACAGCCTC
ATGCTGGTGGACTTCGAGTACAGCAGTTATAACTATAGGGGCTTTGACATTGGGAACCAT
TTTTGTGAGTGGGTTTATGATTATACTCACGAGGAATGGCCTTTCTACAAAGCAAGGCCC
ACAGACTACCCCACTCAAGAACAGCAGTTGCATTTTATTCGTCATTACCTGGCAGAGGCA
AAGAAAGGTGAGACCCTCTCCCAAGAGGAGCAGAGAAAACTGGAAGAAGATTTGCTGGTA
GAAGTCAGTCGGTATGCTCTGGCATCCCATTTCTTCTGGGGTCTGTGGTCCATCCTCCAG
GCATCCATGTCCACCATAGAATTTGGTTACTTGGACTATGCCCAGTCTCGGTTCCAGTTC
TACTTCCAGCAGAAGGGGCAGCTGACCAGTGTCCACTCCTCATCCTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AB029885

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_6_Locus:
22q13.33

# Metabolic_Enzyme_6_SNPs:
Not Available

# Metabolic_Enzyme_6_General_References:
10918069

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5433

# Metabolic_Enzyme_7_Name:
Choline dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_7_Synonyms:
CHD; CDH

# Metabolic_Enzyme_7_Gene_Name:
CHDH

# Metabolic_Enzyme_7_Protein_Sequence:
>Choline dehydrogenase, mitochondrial precursor
MWCLLRGLGRPGALARGALGQQQSLGARALASAGSESRDEYSYVVVGAGSAGCVLAGRLT
EDPAERVLLLEAGPKDVRAGSKRLSWKIHMPAALVANLCDDRYNWCYHTEVQRGLDGRVL
YWPRGRVWGGSSSLNAMVYVRGHAEDYERWQRQGARGWDYAHCLPYFRKAQGHELGASRY
RGADGPLRVSRGKTNHPLHCAFLEATQQAGYPLTEDMNGFQQEGFGWMDMTIHEGKRWSA
ACAYLHPALSRTNLKAEAETLVSRVLFEGTRAVGVEYVKNGQSHRAYASKEVILSGGAIN
SPQLLMLSGIGNADDLKKLGIPVVCHLPGVGQNLQDHLEIYIQQACTRPITLHSAQKPLR
KVCIGLEWLWKFTGEGATAHLETGGFIRSQPGVPHPDIQFHFLPSQVIDHGRVPTQQEAY
QVHVGPMRGTSVGWLKLRSANPQDHPVIQPNYLSTETDIEDFRLCVKLTREIFAQEALAP
FRGKELQPGSHIQSDKEIDAFVRAKADSAYHPSCTCKMGQPSDPTAVVDPQTRVLGVENL
RVVDASIMPSMVSGNLNAPTIMIAEKAADIIKGQPALWDKDVPVYKPRTLATQR

# Metabolic_Enzyme_7_Number_of_Residues:
594

# Metabolic_Enzyme_7_Molecular_Weight:
65402

# Metabolic_Enzyme_7_Theoretical_pI:
8.47

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  FAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  electron transport
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Choline + acceptor = betaine aldehyde + reduced acceptor

# Metabolic_Enzyme_7_Pathway:
map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_7_Reaction:
choline + acceptor = betaine aldehyde + reduced acceptor

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF05199:GMC_oxred_C;
PF00732:GMC_oxred_N

# Metabolic_Enzyme_7_Signals:
1-15

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.1.99.1

# Metabolic_Enzyme_7_GenBank_ID_Protein:
21759795

# Metabolic_Enzyme_7_SwissProt_ID:
CHDH_HUMAN (Q8NE62)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
CHDH

# Metabolic_Enzyme_7_Geneatlas_id:
CHDH

# Metabolic_Enzyme_7_hgnc_id:
HGNC:24288

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Mitochondrion (Potential)

# Metabolic_Enzyme_7_Gene_Sequence:
>1785 bp
ATGTGGTGTCTCCTACGAGGCCTGGGCCGGCCTGGAGCCCTGGCACGGGGAGCCCTGGGG
CAGCAGCAATCCCTGGGTGCCCGGGCCCTGGCCAGCGCAGGCTCTGAGAGCCGGGACGAG
TACAGCTATGTGGTGGTGGGCGCGGGCTCGGCGGGCTGCGTGCTGGCTGGGAGGCTCACG
GAGGACCCCGCCGAGCGCGTGCTGCTGCTGGAGGCCGGGCCCAAGGACGTGCGCGCGGGG
AGCAAGCGGCTCTCGTGGAAGATCCACATGCCCGCGGCCCTGGTGGCCAACCTGTGCGAC
GACAGGTACAACTGGTGCTACCACACAGAGGTGCAGCGGGGCCTGGACGGCCGCGTGCTG
TACTGGCCACGCGGCCGCGTCTGGGGTGGCTCCTCATCCCTCAATGCCATGGTCTACGTC
CGTGGGCACGCCGAGGACTACGAGCGCTGGCAGCGCCAGGGCGCCCGCGGCTGGGACTAC
GCGCACTGCCTGCCCTACTTCCGCAAGGCGCAGGGCCACGAGCTGGGCGCCAGCCGGTAC
CGGGGCGCCGATGGCCCGCTGCGGGTGTCCCGGGGCAAGACCAACCACCCGCTGCACTGC
GCATTCCTGGAGGCCACGCAGCAGGCCGGCTACCCGCTCACCGAGGACATGAATGGCTTC
CAGCAGGAGGGCTTCGGCTGGATGGACATGACCATCCATGAAGGCAAACGGTGGAGCGCA
GCCTGTGCCTACCTGCACCCAGCACTGAGCCGCACCAACCTCAAGGCCGAGGCCGAGACG
CTTGTGAGCAGGGTGCTATTTGAGGGCACCCGTGCAGTGGGCGTGGAGTATGTCAAGAAT
GGCCAGAGCCACAGGGCTTATGCCAGCAAGGAGGTGATTCTGAGTGGAGGTGCCATCAAC
TCTCCACAGCTGCTCATGCTCTCTGGCATCGGGAATGCTGATGACCTCAAGAAACTGGGC
ATCCCTGTGGTGTGCCACCTACCTGGGGTTGGCCAGAACCTGCAAGACCACCTGGAGATC
TACATTCAGCAGGCATGCACCCGCCCTATCACCCTCCATTCAGCACAGAAGCCCCTGCGG
AAGGTCTGCATTGGTCTGGAGTGGCTCTGGAAATTCACAGGGGAGGGAGCCACTGCCCAT
CTGGAAACAGGTGGGTTCATCCGCAGCCAGCCTGGGGTCCCCCACCCGGACATCCAGTTC
CATTTCCTGCCATCCCAAGTGATTGACCACGGGCGGGTCCCCACCCAGCAGGAGGCTTAC
CAGGTACATGTGGGGCCCATGCGGGGCACGAGTGTGGGCTGGCTCAAACTGAGAAGTGCC
AATCCCCAAGACCACCCTGTGATCCAGCCCAACTACTTGTCAACAGAAACTGATATTGAG
GATTTCCGTCTGTGTGTGAAGCTCACCAGAGAAATTTTTGCACAGGAAGCCCTGGCTCCG
TTCCGAGGGAAAGAGCTCCAGCCAGGAAGCCACATTCAGTCAGATAAAGAGATAGATGCC
TTTGTGCGGGCAAAAGCCGACAGCGCCTACCACCCCTCGTGCACCTGTAAGATGGGCCAG
CCCTCCGATCCCACTGCCGTGGTGGATCCGCAGACAAGGGTCCTCGGGGTGGAAAACCTC
AGGGTCGTCGATGCCTCCATCATGCCTAGCATGGTCAGCGGCAACCTGAACGCCCCCACA
ATCATGATCGCAGAGAAGGCAGCTGACATTATCAAGGGGCAGCCTGCACTCTGGGACAAA
GATGTCCCTGTCTACAAGCCCAGGACGCTGGCCACCCAGCGCTAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
BC034502

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_7_Locus:
3p21.1

# Metabolic_Enzyme_7_SNPs:
rs9001; rs34974961; rs2241808; rs7641850; rs17053532; rs35375185; rs35064726; rs930367; rs4687590; rs6793451; rs6807783; rs4687591; rs9835128; rs2015498; rs6445607; rs4687747; rs920253; rs13317328; rs6445608; rs6801605; rs7643016; rs2118421; rs9812916; rs2289206; rs7620929; rs3774616; rs2289207; rs7647880; rs3774617; rs11718497; rs2276838; rs7632578; rs6804251; rs7626693; rs12634827; rs4687589; rs11716282; rs34500349; rs4687748; rs7634578; rs9855967; rs11914948; rs13321117; rs9854886; rs2884632; rs2196663; rs9824744; rs12637132; rs9877386; rs2289209; rs9836592; rs6445606; rs7625247; rs9863776; rs2241807; rs893368; rs2289208; rs11714712; rs4563403; rs4687744; rs11130381; rs4687588; rs12485507; rs4234642; rs17053530; rs12485510; rs12676; rs3209093; rs34336629; rs35642771; rs34905899; rs11391630; rs5849008; rs10663777; rs4687746; rs2118422; rs4687749; rs4687750; rs35580724; rs2164815; rs35890881; rs6807496; rs3079408; rs13080845; rs10636132; rs35892434; rs6782485; rs930366; rs10713985; rs10703989; rs34971544; rs35544897; rs11711312; rs9872403; rs13088829; rs35491417; rs9860224; rs13069101; rs13086547; rs9881815; rs34939200; rs34021192; rs34884918; rs11287903; rs9830723; rs34004134; rs35518479; rs34827407; rs9848701; rs7644115; rs34858459; rs28744591; rs28563804; rs34378181; rs10626142; rs3079411; rs10154841; rs1025689; rs10490844; rs11919668; rs14165; rs1561303; rs17641133; rs2232330; rs2232335; rs2232336; rs2232337; rs2232338; rs2276839; rs2289205; rs28385739; rs34241531; rs35403974; rs3733075; rs3755817; rs3774618; rs4261872; rs4364157; rs4371507; rs4687587; rs4687743; rs6445605; rs7614233; rs7620619; rs7627178; rs7636327; rs7637792; rs7650686; rs877483; rs877484; rs881883; rs893362; rs893363; rs9878562; rs999514; rs999515

# Metabolic_Enzyme_7_General_References:
Not Available

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5774

# Metabolic_Enzyme_8_Name:
Cholinesterase precursor

# Metabolic_Enzyme_8_Synonyms:
Acylcholine acylhydrolase; Choline esterase II; Butyrylcholine esterase; Pseudocholinesterase

# Metabolic_Enzyme_8_Gene_Name:
BCHE

# Metabolic_Enzyme_8_Protein_Sequence:
>Cholinesterase precursor
MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLR
FKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSED
CLYLNVWIPAPKPKNATVLIW
IYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGA
LGFLALPGNPEAPGNMGLFDQQLALQWVQKNI
AAFGGNPKSVTLFGESAGAASVSLHLL
SPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGC
SRENETEIIKCLRNKD
PQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVN
KDEGT
AFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYRE
ALGDV
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVF
GLPLERRDNYTKAEEI
LSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNT
ESTRIMTKLRAQQCRFWTSFFPKVLEM
TGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDY
TSKKESCVGL

# Metabolic_Enzyme_8_Number_of_Residues:
602

# Metabolic_Enzyme_8_Molecular_Weight:
68419

# Metabolic_Enzyme_8_Theoretical_pI:
7.47

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  cholinesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
An acylcholine + H(2)O = choline + a carboxylate

# Metabolic_Enzyme_8_Pathway:
Not Available

# Metabolic_Enzyme_8_Reaction:
An acylcholine + H2O = choline + a carboxylate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF08674:AChE_tetra;
PF00135:COesterase

# Metabolic_Enzyme_8_Signals:
1-28

# Metabolic_Enzyme_8_Transmembrane_Regions:
45-67

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.1.1.8

# Metabolic_Enzyme_8_GenBank_ID_Protein:
1311630

# Metabolic_Enzyme_8_SwissProt_ID:
CHLE_HUMAN (P06276)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
BCHE

# Metabolic_Enzyme_8_Geneatlas_id:
BCHE

# Metabolic_Enzyme_8_hgnc_id:
HGNC:983

# Metabolic_Enzyme_8_PDB_ID:
1P0Q

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_8_Gene_Sequence:
>1809 bp

ATGCATAGCAAAGTCACAATCATATGCATCAGATTTCTCTTTTGGTTTCTTTTGCTCTG
CATGCTTATTG
GGAAGTCACATACTGAAGATGACATCATAATTGCAACAAAGAATGGAA
AAGTCAGAGGGATGAACTTGAC
AGTTTTTGGTGGCACGGTAACAGCCTTTCTTGGAATT
CCCTATGCACAGCCACCTCTTGGTAGACTTCGA
TTCAAAAAGCCACAGTCTCTGACCAA
GTGGTCTGATATTTGGAATGCCACAAAATATGCAAATTCTTGCT
GTCAGAACATAGATC
AAAGTTTTCCAGGCTTCCATGGATCAGAGATGTGGAACCCAAACACTGACCTCAG
TGAA
GACTGTTTATATCTAAATGTATGGATTCCAGCACCTAAACCAAAAAATGCCACTGTATTG
ATATGG
ATTTATGGTGGTGGTTTTCAAACTGGAACATCATCTTTACATGTTTATGATGG
CAAGTTTCTGGCTCGGG
TTGAAAGAGTTATTGTAGTGTCAATGAACTATAGGGTGGGTG
CCCTAGGATTCTTAGCTTTGCCAGGAAA
TCCTGAGGCTCCAGGGAACATGGGTTTATTT
GATCAACAGTTGGCTCTTCAGTGGGTTCAAAAAAATATA
GCAGCCTTTGGTGGAAATCC
TAAAAGTGTAACTCTCTTTGGAGAAAGTGCAGGAGCAGCTTCAGTTAGCC
TGCATTTGC
TTTCTCCTGGAAGCCATTCATTGTTCACCAGAGCCATTCTGCAAAGTGGATCCTTTAATG
C
TCCTTGGGCGGTAACATCTCTTTATGAAGCTAGGAACAGAACGTTGAACTTAGCTAAA
TTGACTGGTTGC
TCTAGAGAGAATGAGACTGAAATAATCAAGTGTCTTAGAAATAAAGA
TCCCCAAGAAATTCTTCTGAATG
AAGCATTTGTTGTCCCCTATGGGACTCCTTTGTCAG
TAAACTTTGGTCCGACCGTGGATGGTGATTTTCT
CACTGACATGCCAGACATATTACTT
GAACTTGGACAATTTAAAAAAACCCAGATTTTGGTGGGTGTTAAT
AAAGATGAAGGGAC
AGCTTTTTTAGTCTATGGTGCTCCTGGCTTCAGCAAAGATAACAATAGTATCATAA
CTA
GAAAAGAATTTCAGGAAGGTTTAAAAATATTTTTTCCAGGAGTGAGTGAGTTTGGAAAGG
AATCCAT
CCTTTTTCATTACACAGACTGGGTAGATGATCAGAGACCTGAAAACTACCGT
GAGGCCTTGGGTGATGTT
GTTGGGGATTATAATTTCATATGCCCTGCCTTGGAGTTCAC
CAAGAAGTTCTCAGAATGGGGAAATAATG
CCTTTTTCTACTATTTTGAACACCGATCCT
CCAAACTTCCGTGGCCAGAATGGATGGGAGTGATGCATGG
CTATGAAATTGAATTTGTC
TTTGGTTTACCTCTGGAAAGAAGAGATAATTACACAAAAGCCGAGGAAATT
TTGAGTAG
ATCCATAGTGAAACGTTGGGCAAATTTTGCAAAATATGGGAATCCAAATGAGACTCAGAA
CA
ATAGCACAAGCTGGCCTGTCTTCAAAAGCACTGAACAAAAATATCTAACCTTGAATA
CAGAGTCAACAAG
AATAATGACGAAACTACGTGCTCAACAATGTCGATTCTGGACATCA
TTTTTTCCAAAAGTCTTGGAAATG
ACAGGAAATATTGATGAAGCAGAATGGGAGTGGAA
AGCAGGATTCCATCGCTGGAACAATTACATGATGG
ACTGGAAAAATCAATTTAACGATT
ACACTAGCAAGAAAGAAAGTTGTGTGGGTCTCTAA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
M32391

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_8_Locus:
3q26.1-q26.2

# Metabolic_Enzyme_8_SNPs:
rs1799807; rs16849700; rs1803274; rs4680607; rs3495; rs4680608; rs12053876; rs4680665; rs4639017; rs7640681; rs4680664; rs4680666; rs4599347; rs4563443; rs7653294; rs4680606; rs4635756; rs1126680; rs5012260; rs7653721; rs17846900; rs7648807; rs7611767; rs4525913; rs1464026; rs2668208; rs2668196; rs7616975; rs1511982; rs1355535; rs1355538; rs6808121; rs6796307; rs2668210; rs9878990; rs1464025; rs3863086; rs1355537; rs13088444; rs829508; rs11922868; rs2048493; rs9823473; rs2668211; rs2668205; rs866164; rs6779207; rs16849671; rs853484; rs2686410; rs2686405; rs2668207; rs12186091; rs6790532; rs2686407; rs4680662; rs2686409; rs9836347; rs2668203; rs6773837; rs1355534; rs9843853; rs2089885; rs9812633; rs829500; rs9873779; rs16849623; rs2668206; rs6807910; rs4680661; rs7619009; rs11922818; rs4263329; rs829501; rs4680663; rs829502; rs2668209; rs9790044; rs16849680; rs7639943; rs6798514; rs16849660; rs11917864; rs9840730; rs7611681; rs7641742; rs12487357; rs12485626; rs2668213; rs7627644; rs7626617; rs7637512; rs7640117; rs16849693; rs829507; rs7636558; rs9881048; rs9883728; rs7653604; rs829503; rs1355536; rs12107166; rs2668204; rs7648794; rs6445067; rs7640586; rs16849681; rs4271957; rs4465985; rs7627742; rs7611687; rs7640920; rs2140086; rs11716439; rs16849620; rs3932260; rs7640679; rs2686411; rs16849668; rs7653122; rs7640930; rs2686408; rs3941625; rs2668202; rs2686402; rs1398088; rs2686401; rs2668201; rs3806650; rs10049436; rs2686403; rs3914191; rs10049010; rs9838443; rs6771914; rs12638339; rs6771817; rs16849721; rs17713196; rs3863085; rs9860697; rs10049434; rs2686404; rs28933389; rs28933390; rs35979453; rs3732880; rs34294242; rs12053993; rs7637636; rs5854163; rs35644761; rs12632049; rs36094063; rs12054031; rs5854165; rs13083740; rs1042406; rs10653588; rs35140012; rs34620327; rs3836432; rs35830841; rs5854164; rs13066003; rs36087072; rs11359412; rs2686406; rs9825995; rs36054054; rs35509667; rs6792881; rs11391808; rs34018532; rs13062800; rs35505024; rs13088495; rs3836431; rs35516032; rs5854161; rs11339534; rs11293664; rs9880251; rs5854157; rs13062946; rs13433934; rs34856025; rs1096091; rs11344476; rs13065864; rs34520453; rs13082307; rs13085409; rs9876165; rs11290371; rs13066624; rs4575939; rs35640056; rs13062371; rs34048563; rs5854162; rs11457535; rs6805552; rs11924595; rs13065704; rs35346450; rs11338147; rs35088735; rs5854158; rs1096092; rs10576839; rs35163888; rs35630052; rs13078924; rs28449205; rs7611187; rs9868011; rs5854160; rs11457904; rs13065865; rs34862658; rs4491958; rs35559394; rs3863087; rs11447348; rs13088494; rs13088631; rs36010215; rs35708800; rs1511981; rs36069345; rs13065858; rs34848459; rs13085219; rs34513680; rs34879616; rs13065832; rs13063273; rs35120541; rs13088096; rs35265354; rs34049446; rs3796266; rs2668212; rs13066287; rs11286831; rs10543813; rs5854159; rs1511995; rs11323460; rs12629801; rs7432645; rs34145392; rs36000048; rs13065871; rs34095385; rs34024060; rs33928098; rs35888986; rs34700940; rs13062755; rs35914904; rs11293617; rs10598350; rs11378582; rs13062373; rs13063299; rs1800581; rs35388629; rs35116657; rs34433489; rs13075264; rs4475077; rs1104453; rs13088623; rs35387439; rs35292169; rs6791825; rs6792085; rs11720167; rs11925572; rs12495720; rs1511973; rs1511974; rs2686393; rs2686394; rs2686395; rs2686399; rs36082133; rs4089857; rs4362765; rs4518174; rs6763777; rs6777367; rs7614736; rs7650626; rs7651298; rs893519; rs893520; rs893521; rs893522; rs958132; rs9832712; rs9864714

# Metabolic_Enzyme_8_General_References:
2322535; 3035536; 3477799; 3542989; 3115973; 3067729; 2915989; 8680411

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
6057

# Metabolic_Enzyme_9_Name:
Choline kinase alpha

# Metabolic_Enzyme_9_Synonyms:
CK; CHETK-alpha

# Metabolic_Enzyme_9_Gene_Name:
CHKA

# Metabolic_Enzyme_9_Protein_Sequence:
>Choline kinase alpha
MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPP
PPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGL
SNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQVRSCNKEGSEQAQKENEFQGAEAMVLE
SVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELGLPDISAEIAEKMATFHGMKM
PFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPV
VFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYP
FFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLW
GQWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV

# Metabolic_Enzyme_9_Number_of_Residues:
457

# Metabolic_Enzyme_9_Molecular_Weight:
52202

# Metabolic_Enzyme_9_Theoretical_pI:
6.52

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  nutrient reservoir activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_9_Specific_Function:
May have a regulatory role in phosphatidylcholine synthesis

# Metabolic_Enzyme_9_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_9_Reaction:
ATP + choline = ADP + O-phosphocholine

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF01633:Choline_kinase

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.7.1.32

# Metabolic_Enzyme_9_GenBank_ID_Protein:
219541

# Metabolic_Enzyme_9_SwissProt_ID:
CHKA_HUMAN (P35790)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
CHKA

# Metabolic_Enzyme_9_Geneatlas_id:
CHKA

# Metabolic_Enzyme_9_hgnc_id:
HGNC:1937

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_9_Gene_Sequence:
>1371 bp
ATGAAAACCAAATTCTGCACCGGGGGCGAGGCGGAGCCCTCGCCGCTCGGGCTGCTGCTG
AGCTGCGGTAGCGGCAGCGCGGCCCCGGCGCCCGGCGTGGGGCAGCAGCGCGACGCCGCC
AGCGACCTCGAGTCCAAGCAGCTGGCGCCAACAGCCGCGCTCGCGCTGCCCCCTCCGCCG
CCGCTGCCGCTGCCGCTGCCGCTGCCCCAGCCCCCGCCGCCGCAGCCGCCCGCAGACGAG
CAGCCGGAGCCCCGGGCGCGGCGCAGGGCCTATCTGTGGTGCAAGGAGTTCCTGCCCGGC
GCCTGGCGGGGCCTCCGCGAGGACGAGTTCCACATCAGTGTCATCAGAGGCGGCCTTAGC
AACATGCTGTTCCAGTGCTCCCTACCTGACACCACAGCCACCCTTGGTGATGAGCCTCGG
AAAGTGCTCCTGCGGCTGTATGGAGCGATTTTGCAGATGAGGTCCTGTAATAAAGAGGGA
TCCGAACAAGCTCAGAAAGAAAATGAATTTCAAGGGGCTGAGGCCATGGTTCTGGAGAGC
GTTATGTTTGCCATTCTCGCAGAGAGGTCACTTGGGCCAAAACTCTATGGCATCTTTCCC
CAAGGCCGACTGGAGCAGTTCATCCCGAGCCGGCGATTAGATACTGAAGAATTAAGTTTG
CCAGATATTTCTGCAGAAATCGCCGAGAAAATGGCTACATTTCATGGTATGAAAATGCCA
TTCAATAAGGAACCAAAATGGCTTTTTGGCACAATGGAAAAGTATCTAAAGGAAGTGCTG
AGAATTAAATTTACTGAGGAATCCAGAATTAAAAAGCTCCACAAATTGCTCAGTTACAAT
CTGCCCTTGGAACTGGAAAACCTGAGATCATTGCTTGAATCTACTCCATCTCCAGTTGTA
TTTTGTCATAATGACTGTCAAGAAGGTAATATCTTGTTGCTGGAAGGCCGAGAGAATTCT
GAAAAACAGAAACTGATGCTCATTGATTTCGAATACAGCAGTTACAATTACAGGGGATTC
GACATTGGAAATCACTTCTGTGAGTGGATGTATGATTATAGCTATGAAAAATACCCTTTT
TTCAGAGCAAACATCCGGAAGTATCCCACCAAGAAACAACAGCTCCATTTTATTTCCAGT
TACTTGCCTGCATTCCAAAATGACTTTGAAAACCTCAGTACTGAAGAAAAATCCATTATA
AAAGAAGAAATGTTGCTTGAAGTTAATAGGTTTGCCCTTGCATCTCATTTCCTCTGGGGA
CTGTGGTCCATTGTACAAGCCAAGATTTCATCTATTGAATTTGGGTACATGGACTACGCC
CAAGCAAGGTTTGATGCCTATTTCCACCAGAAGAGGAAGCTTGGGGTGTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
D10704

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_9_Locus:
11q13.2

# Metabolic_Enzyme_9_SNPs:
rs11481; rs3794186; rs2457179; rs2511437; rs2512611; rs2457180; rs2511439; rs2512608; rs3133327; rs10791956; rs4073551; rs4930557; rs10791957; rs7127838; rs11228130; rs6591331; rs7928739; rs7123183; rs3819255; rs2512612; rs2298838; rs7925423; rs7950522; rs3763944; rs7925022; rs2511436; rs11228131; rs7940217; rs7938199; rs7925469; rs7937999; rs12807448; rs7950397; rs7950573; rs4420277; rs7123035; rs4930227; rs7938921; rs11228129; rs3763945; rs17597141; rs7104982; rs11535788; rs4424674; rs12808793; rs11228136; rs3935460; rs7950392; rs17148849; rs2512613; rs10896293; rs7950931; rs7123668; rs2512605; rs7105399; rs7938618; rs4564342; rs11228137; rs17853642; rs17853641; rs17857113; rs34553252; rs11538783; rs35157598; rs11457659; rs35617414; rs35004137; rs35142362; rs35389644; rs12803471; rs34720656; rs35418990; rs11228134; rs34128268; rs35384388; rs34541282; rs34956463; rs35129218; rs35794217; rs35686875; rs34904228; rs1703432; rs12282027; rs12361957; rs12789942; rs35295698; rs1793253; rs34157126; rs34596220; rs11604971; rs35053057; rs11824199; rs34435704; rs12275388; rs35240421; rs10219148; rs35442893; rs5792434; rs35120244; rs2457178; rs35772606; rs12270493; rs34730110; rs35079920; rs35029853; rs34533021; rs36104066; rs4506665; rs35789171; rs12796123; rs10610679; rs11823508; rs34788775; rs12363368; rs11449775; rs34744029; rs34246417; rs11337805; rs11308249; rs11405927; rs34360525; rs10577551; rs34524538; rs12808580; rs12365493; rs7119627; rs12792899; rs11311764; rs35489750; rs35389934; rs12294243; rs35331639; rs11228133; rs10708078; rs11607831; rs1703439; rs35566839; rs35303746; rs35851358; rs4337046; rs2511435; rs35423222; rs35678072; rs10623242; rs3763946; rs11228135; rs34919967; rs35264251; rs35880888; rs35356476; rs1703431; rs12294244; rs9666593; rs35679572; rs35538423; rs35046555; rs35672679; rs34534250; rs35141094; rs4400816; rs4460814; rs11228132; rs12282745; rs11422466; rs10598696; rs34261785; rs12289186; rs12226861; rs10791958; rs11228127; rs12418239; rs2075609; rs2471829; rs34174828; rs34211419; rs34227834; rs35089741; rs3808974; rs3888690; rs7127090; rs7928374; rs7940113; rs7944372

# Metabolic_Enzyme_9_General_References:
1618328

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
8634

# Metabolic_Enzyme_10_Name:
Phosphoethanolamine/phosphocholine phosphatase

# Metabolic_Enzyme_10_Synonyms:
Not Available

# Metabolic_Enzyme_10_Gene_Name:
PHOSPHO1

# Metabolic_Enzyme_10_Protein_Sequence:
>Phosphoethanolamine/phosphocholine phosphatase
MSGCFPVSGLRCLSRDGRMAAQGAPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLR
ATYREGFYNEYMQRVFKYLGEQGVRPRDLSAIYEAIPLSPGMSDLLQFVAKQGACFEVIL
ISDANTFGVESSLRAAGHHSLFRRILSNPSGPDARGLLALRPFHTHSCARCPANMCKHKV
LSDYLRERAHDGVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEP
SSFRASVVPWETAADVRLHLQQVLKSC

# Metabolic_Enzyme_10_Number_of_Residues:
267

# Metabolic_Enzyme_10_Molecular_Weight:
29713

# Metabolic_Enzyme_10_Theoretical_pI:
7.78

# Metabolic_Enzyme_10_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Not Available

# Metabolic_Enzyme_10_Specific_Function:
Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). May be involved in the generation of inorganic phosphate for bone mineralization

# Metabolic_Enzyme_10_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_10_Reaction:
(1) O-phosphoethanolamine + H2O = ethanolamine + phosphate; (2) phosphocholine + H2O = choline + phosphate

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF06888:Put_Phosphatase

# Metabolic_Enzyme_10_Signals:
Not Available

# Metabolic_Enzyme_10_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 3.1.3.75

# Metabolic_Enzyme_10_GenBank_ID_Protein:
20196839

# Metabolic_Enzyme_10_SwissProt_ID:
PHOP1_HUMAN (Q8TCT1)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
PHOSPHO1

# Metabolic_Enzyme_10_Geneatlas_id:
PHOSPHO1

# Metabolic_Enzyme_10_hgnc_id:
HGNC:16815

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_10_Gene_Sequence:
>804 bp
ATGAGTGGCTGTTTTCCAGTTTCTGGCCTCCGCTGCCTATCTAGGGACGGCAGGATGGCC
GCGCAGGGCGCGCCGCGCTTCCTCCTGACCTTCGACTTCGACGAGACTATCGTGGACGAA
AACAGCGACGATTCGATCGTGCGCGCCGCGCCGGGCCAGCGGCTCCCGGAGAGCCTGCGA
GCCACCTACCGCGAGGGCTTCTACAACGAGTACATGCAGCGCGTCTTCAAGTACCTGGGC
GAGCAGGGCGTGCGGCCGCGGGACCTGAGCGCCATCTACGAAGCCATCCCTTTGTCGCCA
GGCATGAGCGACCTGCTGCAGTTTGTGGCAAAACAGGGCGCCTGCTTCGAGGTGATTCTC
ATCTCCGATGCCAACACCTTTGGCGTGGAGAGCTCGCTGCGCGCCGCCGGCCACCACAGC
CTGTTCCGCCGCATCCTCAGCAACCCGTCGGGGCCGGATGCGCGGGGACTGCTGGCTCTG
CGGCCGTTCCACACACACAGCTGCGCGCGCTGCCCCGCCAACATGTGCAAGCACAAGGTG
CTCAGCGACTACCTGCGCGAGCGGGCCCACGACGGCGTGCACTTCGAGCGCCTCTTCTAC
GTGGGCGACGGCGCCAACGACTTCTGCCCCATGGGGCTGCTGGCGGGCGGCGACGTGGCC
TTCCCGCGCCGCGGCTACCCCATGCACCGCCTCATTCAGGAGGCCCAGAAGGCCGAGCCC
AGCTCGTTCCGCGCCAGCGTGGTGCCCTGGGAAACGGCTGCAGATGTGCGCCTCCACCTG
CAACAGGTGCTGAAGTCGTGCTGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
AJ457189

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_10_Locus:
17q21.32

# Metabolic_Enzyme_10_SNPs:
rs605256; rs16947328; rs617182; rs7209175; rs648980; rs35026928; rs36036830; rs34068372; rs35194032; rs8065011; rs34692121; rs34555265; rs9889994; rs850527; rs850528; rs850529; rs9807042; rs35981831; rs34982306; rs36060151; rs11654776; rs1719897; rs2233368; rs2233369; rs2233370; rs2233371; rs2233372; rs2233374; rs2293218; rs34580297; rs35031462; rs597882; rs608725; rs616338; rs623682; rs624177; rs627386; rs658979; rs671095; rs686259; rs687650; rs7219391; rs727108; rs850522

# Metabolic_Enzyme_10_General_References:
12464021

# Metabolic_Enzyme_10_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7556

# Macromolecular_Interacting_Partner_1_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_1_Signals:
1-18

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_1_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_1_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_1_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_1_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_1_References:
15774573; 16099733; 16112968

# Macromolecular_Interacting_Partner_2_ID:
7010

# Macromolecular_Interacting_Partner_2_Name:
Proactivator polypeptide precursor [Contains: Saposin A

# Macromolecular_Interacting_Partner_2_Synonyms:
Protein A; Saposin B-Val; Saposin B; Sphingolipid activator protein 1; SAP-1; Cerebroside sulfate activator; CSAct; Dispersin; Sulfatide/GM1 activator; Saposin C; Co-beta-glucosidase; A1 activator; Glucosylceramidase activator; Sphingolipid activator protein 2; SAP-2; Saposin D; Protein C; Component C]

# Macromolecular_Interacting_Partner_2_Gene_Name:
PSAP

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Proactivator polypeptide precursor Contains: Saposin 
AMYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVK
SLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILD
IIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLL
YPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMAD
ICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELV
EPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQE
VVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYL
DRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKI
GACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
524

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
58113

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
4.82

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  sphingolipid metabolism
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  vacuole
Component:  lytic vacuole
Component:  lysosome

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Saposin D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12)

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF02199:SapA;
PF05184:SapB_1;
PF03489:SapB_2

# Macromolecular_Interacting_Partner_2_Signals:
1-16

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
220064

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
SAP_HUMAN (P07602)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
PSAP

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
PSAP

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:9498

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Lysosome

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1584 bp
ATGTACGCCCTCTTCCTCCTGGCCAGCCTCCTGGGCGCGGCTCTAGCCGGCCCGGTCCTT
GGACTGAAAGAATGCACCAGGGGCTCGGCAGTGTGGTGCCAGAATGTGAAGACGGCGTCC
GACTGCGGGGCAGTGAAGCACTGCCTGCAGACCGTTTGGAACAAGCCAACAGTGAAATCC
CTTCCCTGCGACATATGCAAAGACGTTGTCACCGCAGCTGGTGATATGCTGAAGGACAAT
GCCACTGAGGAGGAGATCCTTGTTTACTTGGAGAAGACCTGTGACTGGCTTCCGAAACCG
AACATGTCTGCTTCATGCAAGGAGATAGTGGACTCCTACCTCCCTGTCATCCTGGACATC
ATTAAAGGAGAAATGAGCCGTCCTGGGGAGGTGTGCTCTGCTCTCAACCTCTGCGAGTCT
CTCCAGAAGCACCTAGCAGAGCTGAATCACCAGAAGCAGCTGGAGTCCAATAAGATCCCA
GAGCTGGACATGACTGAGGTGGTGGCCCCCTTCATGGCCAACATCCCTCTCCTCCTCTAC
CCTCAGGACGGCCCCCGCAGCAAGCCCCAGCCAAAGGATAATGGGGACGTTTGCCAGGAC
TGCATTCAGATGGTGACTGACATCCAGACTGCTGTACGGACCAACTCCACCTTTGTCCAG
GCCTTGGTGGAACATGTCAAGGAGGAGTGTGACCGCCTGGGCCCTGGCATGGCCGACATA
TGCAAGAACTATATCAGCCAGTATTCTGAAATTGCTATCCAGATGATGATGCACATGCAG
GATCAGCAACCCAAGGAGATCTGTGCGCTGGTTGGGTTCTGTGATGAGGTGAAAGAGATG
CCCATGCAGACTCTGGTCCCCGCCAAAGTGGCCTCCAAGAATGTCATCCCTGCCCTGGAA
CTGGTGGAGCCCATTAAGAAGCACGAGGTCCCAGCAAAGTCTGATGTTTACTGTGAGGTG
TGTGAATTCCTGGTGAAGGAGGTGACCAAGCTGATTGACAACAACAAGACTGAGAAAGAA
ATACTCGACGCTTTTGACAAAATGTGCTCGAAGCTGCCGAAGTCCCTGTCGGAAGAGTGC
CAGGAGGTGGTGGACACGTACGGCAGCTCCATCCTGTCCATCCTGCTGGAGGAGGTCAGC
CCTGAGCTGGTGTGCAGCATGCTGCACCTCTGCTCTGGCACGCGGCTGCCTGCACTGACC
GTTCACGTGACTCAGCCAAAGGACGGTGGCTTCTGCGAAGTGTGCAAGAAGCTGGTGGGT
TATTTGGATCGCAACCTGGAGAAAAACAGCACCAAGCAGGAGATCCTGGCTGCTCTTGAG
AAAGGCTGCAGCTTCCTGCCAGACCCTTACCAGAAGCAGTGTGATCAGTTTGTGGCAGAG
TACGAGCCCGTGCTGATCGAGATCCTGGTGGAGGTGATGGATCCTTCCTTCGTGTGCTTG
AAAATTGGAGCCTGCCCCTCGGCCCATAAGCCCTTGTTGGGAACTGAGAAGTGTATATGG
GGCCCAAGCTACTGGTGCCAGAACACAGAGACAGCAGCCCAGTGCAATGCTGTCGAGCAT
TGCAAACGCCATGTGTGGAACTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
D00422

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_2_Locus:
10q21-q22

# Macromolecular_Interacting_Partner_2_SNPs:
rs2070188; rs7869; rs1055754; rs2394846; rs762571; rs1015193; rs4237331; rs720295; rs7899959; rs7905774; rs7922255; rs885828; rs4237332; rs4747202; rs4747206; rs2070968; rs2394845; rs4747207; rs1900498; rs7350390; rs728289; rs2394844; rs6480560; rs9663508; rs2593163; rs749823; rs3747860; rs6480561; rs3819341; rs6480559; rs11000017; rs10740391; rs727414; rs2249814; rs2121535; rs7912803; rs2854986; rs7093252; rs10823852; rs3747855; rs11000020; rs16929408; rs11598989; rs11596365; rs4747203; rs12413995; rs10762483; rs4747204; rs4747208; rs11000016; rs12414356; rs2854992; rs11000025; rs727415; rs4747205; rs2166630; rs16913438; rs10762484; rs2854987; rs1900499; rs4454640; rs7917605; rs11000018; rs12413014; rs4746095; rs10762482; rs12415202; rs762573; rs12769743; rs1811087; rs2290023; rs7918049; rs11813373; rs9665661; rs11592448; rs9415055; rs11591470; rs7916568; rs7917015; rs11818931; rs2394843; rs11000019; rs4747209; rs7898293; rs4747210; rs11598617; rs9299509; rs9299510; rs12261323; rs1803650; rs11555015; rs11555016; rs11555021; rs11555017; rs1049882; rs1056711; rs1054851; rs1054293; rs11555018; rs41282246; rs11555020; rs36076120; rs14595; rs1053333; rs12844; rs28365839; rs1803651; rs2121536; rs7090110; rs11596605; rs35320964; rs34332602; rs2593164; rs11000024; rs7091271; rs9416009; rs2854984; rs5786051; rs34551152; rs11415214; rs2593162; rs5786050; rs959189; rs7898921; rs1894270; rs8181334; rs7477139; rs35814383; rs36035697; rs11595017; rs1867981; rs12266725; rs9416010; rs7072424; rs2854990; rs7098225; rs11277133; rs35027678; rs12220614; rs5786049; rs11000023; rs28535035; rs12571681; rs35131935; rs12247334; rs34701833; rs9415054; rs12782637; rs12252719; rs41307569; rs7922360; rs2854989; rs7911004; rs11285654; rs3061818; rs2593161; rs11000026; rs2854985; rs2854991; rs11305283; rs7899796; rs34761785; rs7072021; rs11000021; rs12247599; rs2854988; rs7076038; rs5007340; rs10566090; rs2305203; rs41306532; rs3891337; rs762572; rs5007339; rs10566091; rs2593160; rs3878001; rs35837949; rs7068078; rs35439306; rs12217799; rs35407936; rs34509443; rs35534537; rs2121537; rs35068924; rs11598625; rs34150455; rs28365838; rs7897854; rs34228343; rs10390; rs1054635; rs10762485; rs11000030; rs12252818; rs12416292; rs12774485; rs13377076; rs16929375; rs16929427; rs1867978; rs1992823; rs2290021; rs2290022; rs2394840; rs3802707; rs4746097; rs4747197; rs4747198; rs4747199; rs6480562; rs7085713; rs7092990; rs9415051; rs9415053

# Macromolecular_Interacting_Partner_2_General_References:
2515150; 2498298; 2842863; 1612590; 8323276; 1958198; 2013321; 2717620; 8370464; 2825202; 2868718; 3242555; 2209618; 3442600; 2845979; 3048308; 10562467; 7730378; 11180632; 10406958; 12510003; 10510427; 12518053; 7866401; 2302219; 2320574; 2019586; 2060627

# Macromolecular_Interacting_Partner_2_References:
15616594; 15897461; 16041490; 16342325

# Macromolecular_Interacting_Partner_3_ID:
8046

# Macromolecular_Interacting_Partner_3_Name:
Sodium-dependent dopamine transporter

# Macromolecular_Interacting_Partner_3_Synonyms:
DA transporter; DAT

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC6A3

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Sodiumdependent dopamine transporter
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
620

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
68496

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  transporter activity
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
Function:  dopamine:sodium symporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
69-89
96-116
140-160
238-256
265-282
318-335
347-368
401-420
447-465
481-501
522-541
560-578

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
553260

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
SC6A3_HUMAN (Q01959)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC6A3

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC6A3

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:11049

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>278 bp
GCTGCACTATCTCTTCTCCTCCTTCACCACGGAGCTCCCCTGGATCCACTGCAACAACTC
CTGGAACAGCCCCAACTGCTCGGATGCCCATCCTGGTGACTCCAGTGGAGACAGCTCGGG
CCTCAACGACACTTTTGGGACCACACCTGCTGCCGAGTACTTTGAACGTGGCGTGCTGCA
CCTCCACCAGAGCCATGGCATCGACGACCTGGGGCCTCCGCGGTGGCAGCTCACAGCCTG
CCTGGTGCTGGTCATCGTGCTGCTCTACTTCAGCCTCT

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
M96670

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_3_Locus:
5p15.3

# Macromolecular_Interacting_Partner_3_SNPs:
rs2270912; rs6349; rs8179034; rs6347; rs6880875; rs8179035; rs28363072; rs6348; rs27072; rs1042098; rs403798; rs3797200; rs7732456; rs1809939; rs11564774; rs16877691; rs28363170; rs28363174; rs1042128; rs28363166; rs9312841; rs6876890; rs28363168; rs9312842; rs2975284; rs461753; rs460700; rs463379; rs27047; rs456082; rs37021; rs461677; rs458334; rs37022; rs2963253; rs10072058; rs11133767; rs40184; rs2975292; rs11737901; rs6869645; rs10052985; rs2617577; rs460000; rs459141; rs410209; rs2042449; rs456774; rs462523; rs458609; rs464049; rs3776512; rs3834250; rs250686; rs11564759; rs11564762; rs460007; rs462053; rs4975646; rs11564767; rs8179031; rs427284; rs465130; rs16878300; rs10053602; rs11564758; rs2617605; rs8179029; rs3776511; rs11564771; rs2550936; rs10155607; rs6876225; rs487781; rs37020; rs429699; rs536616; rs365663; rs246997; rs10052016; rs11133778; rs2245660; rs11564764; rs464061; rs393795; rs466630; rs10040882; rs3776513; rs11133768; rs457894; rs465989; rs409588; rs10074171; rs11564769; rs403636; rs420422; rs27048; rs458632; rs3756451; rs250682; rs28363080; rs28382230; rs11564766; rs28363151; rs28363098; rs2927675; rs456645; rs28363074; rs428280; rs11564763; rs28363085; rs10475006; rs28363160; rs28382252; rs410481; rs28363155; rs2963252; rs11564773; rs28363124; rs28363114; rs28382247; rs2963239; rs28363141; rs28382245; rs28363119; rs2735917; rs2911492; rs2927676; rs2963242; rs28363090; rs250681; rs28363152; rs28363142; rs4975547; rs460934; rs11133770; rs11951672; rs28363115; rs28363120; rs2975291; rs4975641; rs458860; rs28363161; rs28363156; rs28382246; rs28382248; rs28363086; rs40358; rs28363101; rs28363138; rs28382251; rs3842031; rs28363106; rs1048955; rs28363129; rs28363125; rs11953287; rs2937643; rs3776514; rs28382228; rs28363083; rs6886753; rs28363153; rs11564768; rs11564761; rs28363111; rs2173947; rs28363116; rs2927677; rs28363149; rs28363154; rs28363139; rs457702; rs28363109; rs28363126; rs28363157; rs28363159; rs28363133; rs28382242; rs28742608; rs28363077; rs28382254; rs250684; rs28382237; rs28363079; rs28363089; rs28382244; rs28363082; rs10068876; rs10051340; rs1048953; rs378607; rs11564772; rs28382257; rs28382234; rs2652514; rs28363117; rs3056480; rs13169612; rs250683; rs11564765; rs13161905; rs28363104; rs4975638; rs2975293; rs28363078; rs28363092; rs10036478; rs28363099; rs28363076; rs2963241; rs28363113; rs10064525; rs11133762; rs2617596; rs6413429; rs12516948; rs11564751; rs2652511; rs6866570; rs28363179; rs28363178; rs3863145; rs28363185; rs28363181; rs28363177; rs6345; rs28364997; rs28364996; rs35337610; rs28364998; rs28363169; rs1042130; rs28363171; rs41282613; rs28363172; rs28363175; rs426305; rs1042125; rs11564775; rs1042132; rs1042129; rs2652504; rs28363167; rs41280377; rs28363173; rs34377601; rs2735933; rs28363069; rs11738968; rs34840629; rs2735910; rs28656867; rs2550929; rs459092; rs28382256; rs28382235; rs3836790; rs2927683; rs2975290; rs2963240; rs1677431; rs2652527; rs28363091; rs2963246; rs2652516; rs28382241; rs2652520; rs10582066; rs638964; rs11362775; rs10569377; rs28363102; rs13178805; rs2735913; rs10071624; rs2735929; rs28363131; rs35354514; rs2617611; rs2735922; rs2550924; rs2652519; rs2735914; rs36154293; rs12332091; rs11741877; rs28363070; rs28382239; rs28363087; rs28382226; rs2937642; rs439028; rs28363097; rs423091; rs420334; rs28363107; rs28742609; rs2963244; rs28363122; rs10078288; rs2550938; rs34389905; rs2652532; rs2249823; rs28382240; rs2550958; rs2652524; rs2735926; rs2550928; rs28382236; rs418265; rs28363165; rs11564760; rs2927682; rs13186941; rs28363148; rs11442679; rs34110245; rs501965; rs28363068; rs3776508; rs28363110; rs13171176; rs2550937; rs2859605; rs35841133; rs34211901; rs28380002; rs250685; rs2652525; rs28363084; rs2550933; rs28363136; rs2735932; rs2735916; rs34128392; rs28382249; rs183125; rs2963250; rs28363073; rs371742; rs28382255; rs2963247; rs34976394; rs11273210; rs2617609; rs11564770; rs2617608; rs34049355; rs6880255; rs638577; rs2249815; rs438260; rs28363096; rs11741780; rs2735923; rs13155096; rs36082016; rs34639188; rs2617612; rs168682; rs181776; rs2975285; rs28419783; rs34389111; rs369333; rs28363118; rs28363132; rs10069101; rs28382225; rs28363146; rs28364999; rs27049; rs13163094; rs34946486; rs28407730; rs2652531; rs409928; rs36050264; rs28363158; rs28382231; rs2617580; rs28363164; rs2550932; rs2652517; rs2550923; rs4975640; rs624466; rs2911491; rs28363093; rs2652529; rs2550922; rs2617576; rs13155226; rs2735915; rs28382243; rs10063564; rs28363143; rs28382253; rs2652526; rs2735927; rs2735909; rs28363100; rs28363137; rs37014; rs181775; rs3836789; rs2735920; rs2735931; rs2550926; rs11306694; rs2859606; rs28363121; rs28382258; rs2550927; rs2652518; rs28382229; rs452603; rs28363105; rs2550931; rs2963248; rs34079488; rs28363147; rs2652528; rs10569379; rs2937647; rs35563174; rs28382232; rs28363162; rs2652530; rs2975286; rs2735924; rs2927681; rs2652521; rs34542332; rs28382224; rs6879732; rs2937644; rs2617606; rs3776510; rs2975287; rs185034; rs29001606; rs28363134; rs28363095; rs3822458; rs2617579; rs386538; rs384907; rs9312865; rs28363103; rs624846; rs28382227; rs35190238; rs13162153; rs28363140; rs28363075; rs28382223; rs2652523; rs2735918; rs10069463; rs2963249; rs10072809; rs417608; rs2963251; rs35230954; rs2550935; rs28363128; rs2550930; rs28363088; rs35762146; rs10569378; rs11344041; rs2927684; rs1614919; rs5865370; rs11738604; rs10475005; rs380689; rs2735930; rs375636; rs28363112; rs2859607; rs28363145; rs430512; rs2975289; rs2735928; rs2963245; rs2735921; rs28363144; rs28651372; rs2735908; rs28382233; rs2550959; rs11745189; rs9312866; rs2617607; rs2652515; rs28363108; rs13357809; rs2249538; rs2550925; rs28382250; rs35789472; rs41282615; rs28363123; rs28363130; rs2735911; rs2550934; rs28363127; rs28363081; rs28363071; rs6895518; rs462293; rs401235; rs410246; rs28363163; rs460819; rs2937641; rs28363094; rs6862677; rs2735925; rs2617610; rs2652522; rs2927680; rs408023; rs368273; rs909242; rs28363150; rs451561; rs461854; rs2975288; rs28363135; rs2617578; rs2735852; rs28969507; rs2550957; rs2617598; rs28363183; rs2937637; rs28363184; rs2735853; rs4029364; rs34076103; rs28363180; rs4029363; rs28363176; rs28363186; rs2617597; rs27995; rs28363182; rs10051714; rs10063727; rs10064219; rs10079348; rs11742490; rs11744775; rs12332463; rs12516758; rs13164174; rs13189021; rs1478434; rs2078247; rs2254255; rs2254408; rs2270913; rs2447848; rs2447849; rs2447850; rs2471921; rs2471926; rs2516290; rs2516291; rs2550939; rs2550948; rs2550949; rs2550950; rs2550951; rs2550952; rs2550953; rs2550954; rs2550955; rs2550956; rs2550965; rs2550966; rs2550967; rs2617588; rs2617589; rs2617590; rs2617591; rs2617592; rs2617594; rs2617599; rs2617600; rs2617601; rs2617602; rs2617603; rs2617604; rs2652508; rs2652510; rs27073; rs27074; rs2735847; rs2735848; rs2735849; rs2735850; rs2735851; rs2735855; rs2735856; rs2735857; rs2735934; rs2859604; rs2911493; rs2937629; rs2937635; rs2963238; rs2963256; rs2975225; rs2981359; rs3756450; rs3776485; rs456323; rs464528; rs6346; rs6350; rs8179023

# Macromolecular_Interacting_Partner_3_General_References:
1359373; 1406597; 8302271; 9300814; 10889531; 11304827; 7637582; 1353885; 11343649; 10391209

# Macromolecular_Interacting_Partner_3_References:
16675138

# Macromolecular_Interacting_Partner_4_ID:
8400

# Macromolecular_Interacting_Partner_4_Name:
PEMT protein

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
PEMT

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>PEMT protein
MTRLLGYVDPLDPSFVAAVITITFNPLYWNVVARWEHKTRKLSRAFGSPYLACYSLSITI
LLLNFLRSHCFTQAMLSQPRMESLDTPAAYSLGLALLGLGVVLVLSSFFALGFAGTFLGD
YFGILKEARVTVFPFNILDNPMYWGSTANYLGWAIMHASPTGLLLTVLVALTYIMALLYE
EPFTAEIYRQKASGSHKRS

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
199

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
22180

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.96

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  N-methyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  phospholipid metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF04191:PEMT

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
13-35; 45-67; 88-110; 157-179

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
EC 2.1.1.17

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
48146315

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
Q6IAQ5_HUMAN (Q6IAQ5)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
PEMT

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
PEMT

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:8830

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>600 bp
ATGACCCGGCTGCTGGGCTACGTGGACCCCCTGGATCCCAGCTTTGTGGCTGCCGTCATC
ACCATCACCTTCAATCCGCTCTACTGGAATGTGGTTGCACGATGGGAACACAAGACCCGC
AAGCTGAGCAGGGCCTTCGGATCCCCCTACCTGGCCTGCTACTCTCTAAGCATCACCATC
CTGCTCCTGAACTTCCTGCGCTCGCACTGCTTCACGCAGGCCATGCTGAGCCAGCCCAGG
ATGGAGAGCCTGGACACCCCCGCGGCCTACAGCCTGGGCCTCGCGCTCCTGGGACTGGGC
GTCGTGCTCGTGCTCTCCAGCTTCTTTGCACTGGGGTTCGCTGGAACTTTCCTAGGTGAT
TACTTCGGGATCCTCAAGGAGGCGAGAGTGACCGTGTTCCCCTTCAACATCCTGGACAAC
CCCATGTACTGGGGAAGCACAGCCAACTACCTGGGCTGGGCCATCATGCACGCCAGCCCC
ACGGGCCTGCTCCTGACGGTGCTGGTGGCCCTCACCTACATAATGGCTCTCCTATACGAA
GAGCCCTTCACCGCTGAGATCTACCGGCAGAAAGCCTCCGGGTCCCACAAGAGGAGTTAA


# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
CR457099

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_4_Locus:
17p11.2

# Macromolecular_Interacting_Partner_4_SNPs:
rs7215880; rs897453; rs7946; rs35277795; rs8070432; rs2278952; rs9944423; rs11657719; rs7224725; rs897456; rs7222358; rs4646340; rs4646372; rs7214988; rs744925; rs4924922; rs4244596; rs3816511; rs4646390; rs2124344; rs4646369; rs897451; rs8068641; rs7215055; rs9903468; rs11658311; rs750546; rs4646350; rs4646341; rs4646406; rs1108579; rs4646387; rs1242390; rs4924999; rs9897362; rs11656215; rs9894588; rs729974; rs936108; rs8081152; rs4646391; rs4646400; rs4244593; rs4646342; rs748196; rs4646385; rs4646392; rs6502602; rs6502607; rs7212727; rs6502603; rs8075019; rs746900; rs3760188; rs7216223; rs4646366; rs1109859; rs746899; rs4646389; rs11651620; rs4646396; rs11657678; rs7210978; rs4646405; rs4646394; rs11654842; rs4646343; rs9910747; rs7221487; rs11658944; rs1531100; rs729975; rs747770; rs4244597; rs16961834; rs4646357; rs3785499; rs11658872; rs9902188; rs4646398; rs4244594; rs4646365; rs16961840; rs4646393; rs4646384; rs9905032; rs4646371; rs8082417; rs11078388; rs4646349; rs1531099; rs4646361; rs11871667; rs16961845; rs9894321; rs9908984; rs4646362; rs879375; rs8080165; rs4646402; rs8182244; rs13342397; rs4646388; rs1918249; rs4244599; rs8081961; rs7209113; rs4646351; rs3744120; rs2124345; rs4924919; rs11867345; rs9893179; rs12935886; rs8065788; rs897450; rs4646346; rs4646397; rs1531098; rs12948060; rs8064558; rs11654553; rs4646395; rs4646354; rs4646347; rs9889584; rs4646380; rs4646408; rs4924768; rs4646373; rs11650942; rs2011840; rs8079427; rs4646404; rs4646407; rs4244598; rs11651487; rs4646364; rs1020697; rs4646339; rs11078389; rs4646381; rs4646383; rs12103822; rs4924899; rs4646356; rs4646344; rs34208147; rs8078513; rs11869142; rs4646367; rs11871593; rs4646370; rs12325817; rs4646359; rs9900054; rs4646386; rs9905191; rs4646399; rs4646375; rs8066187; rs4646348; rs8074191; rs7217764; rs7217778; rs8074074; rs4646410; rs11554365; rs3210834; rs956967; rs34208950; rs4646345; rs4591203; rs28652618; rs28583584; rs16961894; rs16961893; rs3803760; rs36036181; rs35067643; rs4609908; rs12103899; rs4646379; rs35641752; rs9904004; rs11651280; rs7210306; rs3816512; rs4924962; rs9915993; rs7210045; rs9902092; rs4646409; rs9889795; rs9894937; rs3744118; rs9893413; rs28673199; rs34247616; rs9913942; rs4646352; rs9903779; rs11652423; rs28593591; rs36031923; rs35104205; rs9907435; rs34964188; rs2168345; rs34984950; rs4646368; rs8074742; rs4289052; rs4244592; rs36113854; rs9902662; rs35391474; rs5819616; rs35094462; rs35656361; rs35483834; rs34201475; rs9890856; rs34218034; rs11657282; rs7225421; rs35394600; rs7209262; rs9892560; rs35903619; rs3744117; rs9908873; rs4646403; rs35204704; rs35298651; rs9890062; rs34147353; rs34043571; rs7214367; rs7214152; rs16961862; rs7503754; rs11390381; rs9893962; rs28652813; rs35655048; rs12051584; rs35838363; rs34859672; rs36055396; rs34831596; rs3803759; rs4646363; rs7214825; rs35596897; rs4646353; rs9903503; rs4646338; rs34169185; rs4646382; rs12103816; rs35714797; rs34880566; rs7219779; rs34226191; rs35121550; rs4924933; rs897455; rs5819618; rs11292697; rs11356900; rs35301480; rs28521687; rs16961854; rs11348592; rs4646358; rs28649163; rs35589061; rs9910212; rs9899073; rs11654777; rs34663545; rs10562574; rs3760187; rs35067579; rs28449566; rs34659170; rs34561995; rs34738748; rs34890050; rs748724; rs4646374; rs4646376; rs7214682; rs11301881; rs34096232; rs35143498; rs4646378; rs11379370; rs12946798; rs4646355; rs9904293; rs35504776; rs28699593; rs12945144; rs10401038; rs897452; rs35806836; rs11440669; rs9895028; rs9905560; rs4646401; rs8076828; rs748725; rs35605713; rs4646360; rs35829322; rs34138026; rs28636952; rs9896989; rs12941371; rs34075240; rs12936632; rs4646377; rs5819615; rs11453270; rs7220691; rs12940673; rs12937426; rs12939945; rs16961856; rs11653284; rs12373156; rs35917481; rs4924786; rs35423362; rs11657281; rs34138521; rs3760186; rs1020696; rs936107; rs4597373; rs7216985; rs34422049; rs34552149; rs12449679; rs11652200; rs11867208; rs11868398; rs11869600; rs12937108; rs12938634; rs12941217; rs12951181; rs2232828; rs2232829; rs2232830; rs2232831; rs2232832; rs2232833; rs2232834; rs2232837; rs2350631; rs28435349; rs3760183; rs3760184; rs3760185; rs4479310; rs4924877; rs4924891; rs4924892; rs7219976; rs7220132; rs7220217; rs8066046; rs8077215; rs921843

# Macromolecular_Interacting_Partner_4_General_References:
Not Available

# Macromolecular_Interacting_Partner_4_References:
15836921; 16144842; 16679290

# Macromolecular_Interacting_Partner_5_ID:
7827

# Macromolecular_Interacting_Partner_5_Name:
Choline transporter-like protein 1

# Macromolecular_Interacting_Partner_5_Synonyms:
Solute carrier family 44 member 1; CD92 antigen; CDw92

# Macromolecular_Interacting_Partner_5_Gene_Name:
SLC44A1

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Choline transporterlike protein 1
MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVS
GYDSYGNICGQKNTKLEAIPNSGMDHTQRKYVFFLDPCNLDLINRKIKSVALCVAACPRQ
ELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVN
ISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVL
VWILTILVILGSLGGTGVLWWLYAKQRRSPKETVTPEQLQIAEDNLRALLIYAISATVFT
VILFLIMLVMRKRVALTIALFHVAGKVFIHLPLLVFQPFWTFFALVLFWVYWIMTLLFLG
TTGSPVQNEQGFVEFKISGPLQYMWWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDK
RNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGKENACARCVLK
SCICCLWCLEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALRVATINTVGDFML
FLGKVLIVCSTGLAGIMLLNYQQDYTVWVLPLIIVCLFAFLVAHCFLSIYEMVVDVLFLC
FAIDTKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKGGVADSRELKPMASGASSA

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
657

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
73303

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
8.69

# Macromolecular_Interacting_Partner_5_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Probable choline transporter. May be involved in membrane synthesis and myelin production

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF04515:DUF580

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
31-51
213-233
239-259
289-309
316-336
339-359
381-401
443-463
538-558
567-587

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
19571182

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
CTL1_HUMAN (Q8WWI5)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
SLC44A1

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
SLC44A1

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:18798

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1965 bp
ATGGGCTGCTGCAGCTCCGCTTCCTCCGCCGCGCAGAGCTCCAAACGAGAATGGAAGCCG
CTGGAGGACCGTAGCTGCACAGACATACCATGGCTGCTGCTCTTCATCCTCTTCTGCATT
GGGATGGGATTTATTTGTGGCTTTTCAATAGCAACAGGTGCAGCAGCAAGACTAGTGTCA
GGATACGACAGCTATGGAAATATCTGTGGGCAGAAAAATACAAAGTTGGAAGCAATACCA
AACAGTGGCATGGACCACACCCAGCGGAAGTATGTATTCTTTTTGGATCCATGCAACCTG
GACTTGATAAACCGGAAGATTAAGTCTGTAGCACTGTGTGTAGCAGCGTGTCCAAGGCAA
GAACTGAAAACTCTGAGTGATGTTCAGAAGTTTGCAGAGATAAATGGTTCAGCCCTATGT
AGCTACAACCTAAAGCCTTCTGAATACACTACATCTCCAAAATCTTCTGTTCTCTGCCCC
AAACTACCAGTTCCAGCGAGTGCACCTATTCCATTCTTCCATCGCTGTGCTCCTGTGAAC
ATTTCCTGCTATGCCAAGTTTGCAGAGGCCCTGATCACCTTTGTCAGTGACAATAGTGTC
TTACACAGGCTGATTAGTGGAGTAATGACCAGCAAAGAAATTATATTGGGACTTTGCTTG
TTATCACTAGTTCTATCCATGATTTTGATGGTGATAATCAGGTATATATCAAGAGTACTT
GTGTGGATCTTAACGATTCTGGTCATACTCGGTTCACTTGGAGGCACAGGTGTACTATGG
TGGCTGTATGCAAAGCAAAGAAGGTCTCCCAAAGAAACTGTTACTCCTGAGCAGCTTCAG
ATAGCTGAAGACAATCTTCGGGCCCTCCTCATTTATGCCATTTCAGCTACAGTGTTCACA
GTGATCTTATTCCTGATAATGTTGGTTATGCGCAAACGTGTTGCTCTTACCATCGCCTTG
TTCCACGTAGCTGGCAAGGTCTTCATTCACTTGCCACTGCTAGTCTTCCAACCCTTCTGG
ACTTTCTTTGCTCTTGTCTTGTTTTGGGTGTACTGGATCATGACACTTCTTTTTCTTGGC
ACTACCGGCAGTCCTGTTCAGAATGAGCAAGGCTTTGTGGAGTTCAAAATTTCTGGGCCT
CTGCAGTACATGTGGTGGTACCATGTGGTGGGCCTGATTTGGATCAGTGAATTTATTCTA
GCATGTCAGCAGATGACAGTGGCAGGAGCTGTGGTAACATACTATTTTACTAGGGATAAA
AGGAATTTGCCATTTACACCTATTTTGGCATCAGTAAATCGCCTTATTCGTTACCACCTA
GGTACGGTGGCAAAAGGATCTTTCATTATCACATTAGTCAAAATTCCGCGAATGATCCTT
ATGTATATTCACAGTCAGCTCAAAGGAAAGGAAAATGCTTGTGCACGATGTGTGCTGAAA
TCTTGCATTTGTTGCCTTTGGTGTCTTGAAAAGTGCCTAAATTATTTAAATCAGAATGCA
TACACAGCCACAGCTATCAACAGCACCAACTTCTGCACCTCAGCAAAGGATGCCTTTGTC
ATTCTGGTGGAGAATGCTTTGCGAGTGGCTACCATCAACACAGTAGGAGATTTTATGTTA
TTCCTTGGCAAGGTGCTGATAGTCTGCAGCACAGGTTTAGCTGGGATTATGCTGCTCAAC
TACCAGCAGGACTACACAGTATGGGTGCTGCCTCTGATCATCGTCTGCCTCTTTGCTTTC
CTAGTCGCTCATTGCTTCCTGTCTATTTATGAAATGGTAGTGGATGTATTATTCTTGTGT
TTTGCCATTGATACAAAATACAATGATGGGAGCCCTGGCAGAGAATTCTATATGGATAAA
GTGCTGATGGAGTTTGTGGAAAACAGTAGGAAAGCAATGAAAGAAGCTGGTAAGGGAGGC
GTCGCTGATTCCAGAGAGCTAAAGCCGATGCTGAAGAAAAGGTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AJ245620

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_5_Locus:
9q31.2

# Macromolecular_Interacting_Partner_5_SNPs:
rs3199966; rs2771040; rs328007; rs328019; rs328012; rs2771033; rs328013; rs327990; rs327947; rs328014; rs182756; rs328008; rs2004725; rs327995; rs2812317; rs327950; rs12342542; rs328022; rs6479313; rs327976; rs4549843; rs7042140; rs6479303; rs10820801; rs1360087; rs2100044; rs327983; rs327960; rs1397665; rs10118989; rs186617; rs7867378; rs9299386; rs7026079; rs10991600; rs7873937; rs6479314; rs374445; rs7029443; rs7022737; rs2417615; rs6479304; rs328006; rs327957; rs2417642; rs7034136; rs4538947; rs13297127; rs6479307; rs9299387; rs10991642; rs6479311; rs10820793; rs7868841; rs7048586; rs10991639; rs7020982; rs327984; rs327992; rs11096; rs7860321; rs932006; rs6479309; rs6479306; rs327993; rs10991635; rs10120853; rs7034666; rs328001; rs1397666; rs10081709; rs10991611; rs1037115; rs328018; rs7040751; rs7871427; rs7045091; rs9632901; rs7035065; rs7857293; rs416641; rs327959; rs9299385; rs7858178; rs6479316; rs16924416; rs7019208; rs327987; rs7873924; rs10820798; rs932005; rs327945; rs7858401; rs7039398; rs1410839; rs7859745; rs7856524; rs10991629; rs10991619; rs7021567; rs7874307; rs10491810; rs7024985; rs327996; rs2771043; rs16924529; rs10991617; rs10991598; rs7871855; rs6479315; rs7869261; rs328015; rs7046185; rs12344346; rs2417641; rs1410838; rs12348136; rs10120572; rs2055884; rs7856033; rs12115272; rs13285648; rs12350341; rs7021008; rs10114041; rs12348983; rs376926; rs10820799; rs327958; rs327991; rs7870687; rs10991628; rs9942851; rs10120833; rs328009; rs11506819; rs327997; rs10991640; rs12339823; rs957903; rs328010; rs2900397; rs16924530; rs6479305; rs12350138; rs442605; rs328016; rs327985; rs327978; rs6479310; rs443094; rs7863414; rs9644967; rs6479308; rs10115879; rs375034; rs327948; rs327998; rs327999; rs12344130; rs227888; rs10991607; rs10820795; rs327956; rs327944; rs327982; rs170582; rs7853709; rs7018875; rs12380580; rs16924420; rs10820792; rs6479317; rs1815382; rs10991608; rs2771034; rs10991612; rs16924397; rs10991636; rs7031117; rs12339205; rs327994; rs9632900; rs328002; rs7869167; rs2297022; rs448836; rs424450; rs10991644; rs28545469; rs10991645; rs11788629; rs1553873; rs7865985; rs327980; rs7849407; rs327955; rs10820800; rs12343678; rs328003; rs16924552; rs7020772; rs2149591; rs327988; rs12350767; rs10116656; rs12347209; rs10991609; rs418057; rs12335779; rs7033929; rs16924417; rs327946; rs10991624; rs403316; rs10991613; rs2036876; rs10991633; rs35275407; rs11793675; rs12555203; rs7866899; rs10820794; rs16924386; rs12551215; rs10991614; rs10991601; rs2417614; rs7858967; rs12376222; rs12378850; rs9775852; rs10115888; rs12686574; rs7028738; rs12349416; rs4576475; rs907230; rs10991606; rs10820796; rs13294525; rs167867; rs2771031; rs193008; rs193007; rs328020; rs12345601; rs10991634; rs390336; rs7863781; rs328000; rs328005; rs189020; rs12347364; rs10991620; rs10991602; rs328021; rs327981; rs1969982; rs391386; rs16924395; rs10820797; rs3802436; rs10991630; rs1360088; rs328011; rs7024012; rs12551644; rs10991641; rs10991622; rs4387039; rs327975; rs327986; rs12341869; rs382940; rs2771029; rs10115833; rs7019220; rs328017; rs193009; rs12379026; rs16924542; rs227887; rs12336780; rs10123494; rs10991618; rs13297922; rs7872373; rs328004; rs327949; rs7028183; rs327989; rs179177; rs2089807; rs7863918; rs16924487; rs390529; rs41306484; rs35215533; rs34048538; rs7018714; rs10991648; rs7868345; rs13286370; rs10698238; rs34089918; rs28631110; rs33933201; rs10991649; rs3185800; rs34457096; rs35224846; rs7045688; rs7860539; rs11790172; rs11361823; rs28688962; rs7031423; rs11318297; rs12555851; rs35825389; rs34847101; rs13297419; rs11299759; rs12353322; rs34750132; rs35293517; rs11309650; rs10687403; rs35485876; rs10119817; rs34021714; rs7044901; rs7854282; rs34474972; rs34303537; rs10991625; rs5021615; rs34669661; rs7032322; rs34947116; rs41316536; rs10283529; rs1969981; rs13294539; rs36234028; rs11382735; rs35324360; rs34573916; rs10991632; rs11793508; rs12236320; rs35322610; rs12351598; rs35472593; rs35607725; rs2089808; rs35581862; rs35765843; rs11411266; rs10648191; rs12344454; rs7045395; rs12339674; rs7873870; rs35313280; rs36019711; rs10081753; rs36059530; rs12347204; rs7468896; rs35413260; rs7869142; rs10991604; rs2417613; rs34980884; rs35509318; rs11297763; rs34301462; rs12377753; rs7041237; rs13301136; rs34222278; rs2812319; rs11324785; rs35553187; rs34696658; rs36013485; rs34659648; rs7048497; rs11458949; rs3030594; rs12377755; rs11367194; rs35007675; rs11309651; rs12378298; rs7026389; rs34727875; rs12336768; rs7030205; rs7854064; rs35122601; rs35530318; rs5899653; rs11284181; rs7040500; rs35815321; rs34774588; rs41477944; rs12683101; rs11458684; rs13287472; rs11349356; rs35957774; rs10991599; rs11350240; rs35532819; rs13296308; rs34800024; rs327977; rs7039638; rs10991638; rs7041229; rs35409973; rs5899652; rs10991646; rs9632899; rs7026437; rs16924518; rs34275618; rs379852; rs34979667; rs11390818; rs35099783; rs34331578; rs34772081; rs35183256; rs10991605; rs35533765; rs7851679; rs35772378; rs7039997; rs35241428; rs35710961; rs12341779; rs35168575; rs13293182; rs10283777; rs34137686; rs13299711; rs35592232; rs34449378; rs35267970; rs7035129; rs35888386; rs7043183; rs35477345; rs12684034; rs11339357; rs7467849; rs35616332; rs35412407; rs9777083; rs34561786; rs34612024; rs36112131; rs28587266; rs35534709; rs35583837; rs12345584; rs41296093; rs34957316; rs7034000; rs12378481; rs34253461; rs2771032; rs10991610; rs34802456; rs34526456; rs34074372; rs12345666; rs35950160; rs4524851; rs34179294; rs34261018; rs12346781; rs13289885; rs34177716; rs10559371; rs34468402; rs35335528; rs3929772; rs35206964; rs10524079; rs34336870; rs35913637; rs2028850; rs10589897; rs13293593; rs12379533; rs327979; rs35111325; rs2084147; rs2036875; rs5899654; rs10991623; rs35368197; rs4743813; rs12350782; rs7853151; rs34999484; rs10991647; rs12336008; rs11317572; rs33944504; rs7019052; rs1397667; rs35201205; rs35136938; rs34668343; rs36088962; rs34980157; rs34030286; rs34887993; rs11790973; rs10991637; rs2812318; rs28409512; rs11416029; rs35697234; rs10121261; rs10991650; rs34239939; rs10636321; rs10115083; rs1553871; rs12347297; rs7467844; rs36206520; rs9802380; rs12379958; rs3123346; rs10991643; rs10991615; rs12340015; rs10633966; rs11291439; rs451915; rs13299415; rs1553870; rs7030603; rs9696280; rs34647970; rs35051483; rs35215069; rs12341936; rs34933859; rs10991627; rs34226568; rs34173274; rs2771030; rs35584395; rs4545154; rs7041220; rs41296089; rs13299679; rs327954; rs36077824; rs34054533; rs28512292; rs34883337; rs35088472; rs34214832; rs9696270; rs13299505; rs34780893; rs12379954; rs10991603; rs34333246; rs2900398; rs13298325; rs5899655; rs10991616; rs35633859; rs34274174; rs13293589; rs10991626; rs41424245; rs34629589; rs12353314; rs35357595; rs35449648; rs34154165; rs34856781; rs12343233; rs10583831; rs35157236; rs12342070; rs34504730; rs10991631; rs34400773; rs5021616; rs11296975; rs11286712; rs36028107; rs35603631; rs3030595; rs35455036; rs10660646; rs35930528; rs10121264; rs35672364; rs11336701; rs7041979; rs10719507; rs7044876; rs10113900; rs10114564; rs12115219; rs12115775; rs12340765; rs1410837; rs170583; rs17246524; rs17305886; rs17305963; rs2812314; rs2812315; rs2812316; rs327964; rs327967; rs327968; rs4336666; rs6479302; rs724069

# Macromolecular_Interacting_Partner_5_General_References:
10677542; 11698453

# Macromolecular_Interacting_Partner_5_References:
16319125

# Macromolecular_Interacting_Partner_6_ID:
7869

# Macromolecular_Interacting_Partner_6_Name:
High-affinity choline transporter 1

# Macromolecular_Interacting_Partner_6_Synonyms:
Solute carrier family 5 member 7; Hemicholinium-3-sensitive choline transporter; CHT

# Macromolecular_Interacting_Partner_6_Gene_Name:
SLC5A7

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Highaffinity choline transporter 1
MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTA
TWVGGGYINGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQ
IYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGG
LYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSW
LDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDW
NQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFA
RNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQ
LLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFK
TLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLD
ELALVKPRQSMTLSSTFTNKEAFLDVDSSPEGSGTEDNLQ

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
580

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
63204

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
4.77

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_6_Specific_Function:
Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion- dependent

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00474:SSF

# Macromolecular_Interacting_Partner_6_Signals:
1-25

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
10998442

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
SC5A7_HUMAN (Q9GZV3)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SLC5A7

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SLC5A7

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:14025

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1743 bp
ATGGCTTTCCATGTGGAAGGACTGATAGCTATCATCGTGTTCTACCTTCTAATTTTGCTG
GTTGGAATATGGGCTGCCTGGAGAACCAAAAACAGTGGCAGCGCAGAAGAGCGCAGCGAA
GCCATCATAGTTGGTGGCCGAGATATTGGTTTATTGGTTGGTGGATTTACCATGACAGCT
ACCTGGGTCGGAGGAGGGTATATCAATGGCACAGCTGAAGCAGTTTATGTACCAGGTTAT
GGCCTAGCTTGGGCTCAGGCACCAATTGGATATTCTCTTAGTCTGATTTTAGGTGGCCTG
TTCTTTGCAAAACCTATGCGTTCAAAGGGGTATGTGACCATGTTAGACCCGTTTCAGCAA
ATCTATGGAAAACGCATGGGCGGACTCCTGTTTATTCCTGCACTGATGGGAGAAATGTTC
TGGGCTGCAGCAATTTTCTCTGCTTTGGGAGCCACCATCAGCGTGATCATCGATGTGGAT
ATGCACATTTCTGTCATCATCTCTGCACTCATTGCCACTCTGTACACACTGGTGGGAGGG
CTCTATTCTGTGGCCTACACTGATGTCGTTCAGCTCTTTTGCATTTTTGTAGGGCTGTGG
ATCAGCGTCCCCTTTGCATTGTCACATCCTGCAGTCGCAGACATCGGGTTCACTGCTGTG
CATGCCAAATACCAAAAGCCGTGGCTGGGAACTGTTGACTCATCTGAAGTCTACTCTTGG
CTTGATAGTTTTCTGTTGTTGATGCTGGGTGGAATCCCATGGCAAGCATACTTTCAGAGG
GTTCTCTCTTCTTCCTCAGCCACCTATGCTCAAGTGCTGTCCTTCCTGGCAGCTTTCGGG
TGCCTGGTGATGGCCATCCCAGCCATACTCATTGGGGCCATTGGAGCATCAACAGACTGG
AACCAGACTGCATATGGGCTTCCAGATCCCAAGACTACAGAAGAGGCAGACATGATTTTA
CCAATTGTTCTGCAGTATCTCTGCCCTGTGTATATTTCTTTCTTTGGTCTTGGTGCAGTT
TCTGCTGCTGTTATGTCATCAGCAGATTCTTCCATCTTGTCAGCAAGTTCCATGTTTGCA
CGGAACATCTACCAGCTTTCCTTCAGACAAAATGCTTCGGACAAAGAAATCGTTTGGGTT
ATGCGAATCACAGTGTTTGTGTTTGGAGCATCTGCAACAGCCATGGCCTTGCTGACGAAA
ACTGTGTATGGGCTCTGGTACCTCAGTTCTGACCTTGTTTACATCGTTATCTTCCCCCAG
CTGCTTTGTGTACTCTTTGTTAAGGGAACCAACACCTATGGGGCCGTGGCAGGTTATGTT
TCTGGCCTCTTCCTGAGAATAACTGGAGGGGAGCCATATCTGTATCTTCAGCCCTTGATC
TTCTACCCTGGCTATTACCCTGATGATAATGGTATATATAATCAGAAATTTCCATTTAAA
ACACTTGCCATGGTTACATCATTCTTAACCAACATTTGCATCTCCTATCTAGCCAAGTAT
CTATTTGAAAGTGGAACCTTGCCACCTAAATTAGATGTATTTGATGCTGTTGTTGCAAGA
CACAGTGAAGAAAACATGGATAAGACAATTCTTGTCAAAAATGAAAATATTAAATTAGAT
GAACTTGCACTTGTGAAGCCACGACAGAGCATGACCCTCAGCTCAACTTTCACCAATAAA
GAGGCCTTCCTTGATGTTGATTCCAGTCCAGAAGGGTCTGGGACTGAAGATAATTTACAG
TGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
AF276871

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_6_Locus:
2q12

# Macromolecular_Interacting_Partner_6_SNPs:
rs1013940; rs3731682; rs333226; rs3806531; rs333238; rs2046510; rs333227; rs333236; rs2433718; rs4676168; rs1684070; rs11883519; rs17036563; rs11889263; rs13384641; rs2433717; rs13398078; rs333217; rs333235; rs333216; rs333234; rs6542746; rs333214; rs6753886; rs4676169; rs3731683; rs2450280; rs333223; rs6720783; rs3731684; rs13395214; rs333221; rs6759730; rs10195701; rs11685666; rs333220; rs11685873; rs17269272; rs17036602; rs11678551; rs10187243; rs10187415; rs2450282; rs6753566; rs333219; rs17269265; rs333215; rs2450279; rs17036610; rs333224; rs333213; rs333218; rs17269279; rs333239; rs333240; rs1021247; rs3806536; rs13013808; rs13393493; rs13014176; rs13396984; rs13422385; rs17036533; rs13035398; rs34207775; rs333237; rs10199155; rs35092056; rs10199451; rs28509360; rs333225; rs1684080; rs34062088; rs34200685; rs35374297; rs13020429; rs36121864; rs1155682; rs9789771; rs35900471; rs35318930; rs34049084; rs35756712; rs333222; rs12162406; rs35097745; rs17036632; rs13387198; rs34084090; rs1365812; rs35066858; rs10707418; rs35735838; rs35029295; rs10181373; rs10201138; rs10496417; rs10496418; rs12469531; rs13020302; rs17037009; rs17037084; rs17269293; rs2450281; rs2630505; rs333228; rs333229; rs333230; rs333231; rs333241; rs333242; rs34495004; rs6721036

# Macromolecular_Interacting_Partner_6_General_References:
11027560; 11068039

# Macromolecular_Interacting_Partner_6_References:
15611726; 15665419; 15691711; 15878282

# Macromolecular_Interacting_Partner_7_ID:
8733

# Macromolecular_Interacting_Partner_7_Name:
Choline kinase like protein

# Macromolecular_Interacting_Partner_7_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Choline kinase like protein
VCSGIPFLLGSVVHPPGIHVHHRIWLLGLCPVSVPVLLPAEGAADQCPLLIL

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
52

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
5456

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_7_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Signals:
1-44

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
O15094_HUMAN (O15094)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:1938

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
AB003286

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Locus:
Not Available

# Macromolecular_Interacting_Partner_7_SNPs:
Not Available

# Macromolecular_Interacting_Partner_7_General_References:
9224698

# Macromolecular_Interacting_Partner_7_References:
Not Available

End of HMDB00097

Beginning of HMDB00098
# Accession_No:
HMDB00098

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-09-12 19:03:57

# biospider_lastupdate:
2007-07-24 17:02:14

# Common_Name:
D-Xylose

# Description:
Important intermediate in the Pentose and glucuronate interconversions and Nucleotide sugars metabolism. (KEGG) It is said to be one of eight sugars which are essential for human nutrition, the others being galactose, glucose, mannose, N-acetylglucosamine, N-acetylgalactosamine, fucose, and sialic acid. (wikipedia)

# Synonyms:
d-Xylose; Xylo-pfan; Xyloside; D-(+)-xylose; Xylose; Xylomed; Wood sugar

# Chemical_IUPAC_Name:
(3R,4R,5R)-oxane-2,3,4,5-tetrol

# Chemical_Formula:
C5H10O5

# Chemical_Structure:
tbl_chemical:::HMDB00098_ZOOM.png:::119283188440082644

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00098_THUMB.png:::119283188277098956

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Carbohydrates

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiacetal; secondary alcohol; 1,2-diol; heterocyclic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
150.05283

# Molecular_Weight_Avg:
150.12991

# Smiles_String_isomeric:
O[C@@H]1COC(O)[C@H](O)[C@H]1O

# Smiles_String_canonical:
OC1COC(O)C(O)C1O

# KEGG_Compound_ID:
C00181

# BioCyc_ID:
XYLOSE

# PubChem_CID:
135191

# PubChem_SID:
24870807; 24890196; 14720291; 10243854; 7854749; 3481; 14772280; 24438844; 711441; 24902136; 3134873; 14747878; 24902143; 24902132

# OMIM_ID:
125890; 130070; 260800; 608611; 608124; 608125

# Metagene_ID:
Not Available

# BiGG_ID:
34162

# Wikipedia_ID:
 Wood sugar

# METLIN_ID:
314

# Ref_ID:
9704727; 6548110; 12075057; 2026685; 9765687; 3716508; 11418788; 3751145; 6526497; 2204861; 2060054

# ChEBI_ID:
15936

# CAS_Registry_Number:
58-86-6

# InChI:
InChI=1/C5H10O5/c6-2-1-10-5(9)4(8)3(2)7/h2-9H,1H2/t2-,3+,4-,5?/m1/s1

# Synthesis_Reference:
Pentoside synthesis by dehydrative glycosylation.  Synthesis of O-a-L-arabinofuranosyl-(1®3)-O-b-D-xylopyranosyl-(1®4)-D-xylopyranose.     Koto, Shinkiti; Morishima, Naohiko; Takenaka, Kazuhiro; Uchida, Chisa; Zen, Shonosuke.    Sch. Pharm. Sci.,  Kitasat

# Melting_Point:
90.5 oC

# Melting_Point_predicted:
100.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
555.0 mg/mL [MERCK INDEX (1996)]

# H2O_Solubility_Predicted:
1.22e+03 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.56 [Predicted by ALOGPS]; -1.9 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00098.pdf:::118531813721492086

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::D-Xylose.mol:::116594056932214518

# SDF_File_[Text]:
tbl_chemical:::HMDB00098.sdf:::119283187922558784

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00098.pdb:::119283188140412448

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041014_P00_03_HW_1DP_PRESAT_expanded_2.gif:::114460751236511795

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041014_P00_03_HW_1DP_presat.zip:::1177710633468283890

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041014_P00_03_HW_1DP_Assigned.png:::116552809083391876

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::041014_P00_03_HW_1DC_11.jpg:::114168460138727527

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041014_P00_03_HW_1DC_11.zip:::114168460135986200

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041014_P00_03_HW_1DC_11_Assigned.jpg:::114488095065441067

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041014_P00_03_HW_2DHSQC_15.jpg:::114618052667961173

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041014_P00_03_HW_2DHSQC_15.zip:::114618052701032438

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041014_P00_03_HW_2DHSQC_15_Assigned.jpg:::115887088288445311

# Predicted_H_NMR_Spectrum:
tbl_chemical:::D-Xylose.gif:::1132732108531760808

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00098_peaks.txt:::1156309543093385802

# Predicted_C_NMR_Spectrum:
tbl_chemical:::D-Xylose_C.gif:::1132737683134409574

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00098_peaks.txt:::1156310733337613668

# Mass_Spectrum:
tbl_chemical:::HMDB00098.jpg:::1132798876859557393

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000026.png:::11689082304843492

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000026.txt:::116890823048450809

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000026.png:::116890823009388569

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000026.txt:::116890823048470755

# Cellular_Location:
Cytoplasm; Extracellular; lysosome

# Tissue_Location:
Erythrocyte; Small Intestine

# deuterated:
No

# Biofluid_Location:
Bile; Blood; Feces; Lymph; Saliva; Urine

# Concentration_[Normal]:
Urine	26.7 +/- 23.7	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	2026685


# Concentration_[Abnormal]:
Urine	3.0 (0.0-17.0)	umol/mmol_creatinine	N/A	Both	Lung Cancer	HMP experimental


# Associated_Disorders:
Coeliac Disease; End-stage Renal Disease (ESRD); Hyperglycemia; Lung Cancer

# Pathway_Names:
Pentose and glucuronate interconversions;Fructose and mannose metabolism;Galactose metabolism;Glycerolipid metabolism;Pyruvate metabolism

# Pathway_Images:
;fructose_metabolism.jpg;;;

# KEGG_Images:
map00040;map00051;map00052;map00561;map00620

# Pathway_Graphs:
;fructose_metabolism_Graph.jpg;;;

# Pathway_SBMLs:
;fructose_metabolism.xml;;;

# Metabolic_Enzyme_1_ID:
5320

# Metabolic_Enzyme_1_Name:
Aldose reductase

# Metabolic_Enzyme_1_Synonyms:
AR; Aldehyde reductase

# Metabolic_Enzyme_1_Gene_Name:
AKR1B1

# Metabolic_Enzyme_1_Protein_Sequence:
>Aldose reductase
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF

# Metabolic_Enzyme_1_Number_of_Residues:
316

# Metabolic_Enzyme_1_Molecular_Weight:
35854

# Metabolic_Enzyme_1_Theoretical_pI:
6.99

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies

# Metabolic_Enzyme_1_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism

# Metabolic_Enzyme_1_Reaction:
alditol + NAD(P)+ = aldose + NAD(P)H + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.1.1.21

# Metabolic_Enzyme_1_GenBank_ID_Protein:
178487

# Metabolic_Enzyme_1_SwissProt_ID:
ALDR_HUMAN (P15121)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
AKR1B1

# Metabolic_Enzyme_1_Geneatlas_id:
AKR1B1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:381

# Metabolic_Enzyme_1_PDB_ID:
1T40

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>951 bp
ATGGCAAGCCGTCTCCTGCTCAACAACGGCGCCAAGATGCCCATCCTGGGGTTGGGTACC
TGGAAGTCCCCTCCAGGGCAGGTGACTGAGGCCGTGAAGGTGGCCATTGACGTCGGGTAC
CGCCACATCGACTGTGCCCATGTGTACCAGAATGAGAATGAGGTGGGGGTGGCCATTCAG
GAGAAGCTCAGGGAGCAGGTGGTGAAGCGTGAGGAGCTCTTCATCGTCAGCAAGCTGTGG
TGCACGTACCATGAGAAGGGCCTGGTGAAAGGAGCCTGCCAGAAGACACTCAGCGACCTG
AAGCTGGACTACCTGGACCTCTACCTTATTCACTGGCCGACTGGCTTTAAGCCTGGGAAG
GAATTTTTCCCATTGGATGAGTCGGGCAATGTGGTTCCCAGTGACACCAACATTCTGGAC
ACGTGGGCGGCCATGGAAGAGCTGGTGGATGAAGGGCTGGTGAAAGCTATTGGCATCTCC
AACTTCAACCATCTCCAGGTGGAGATGATCTTAAACAAACCTGGCTTGAAGTATAAGCCT
GCAGTTAACCAGATTGAGTGCCACCCATATCTCACTCAGGAGAAGTTAATCCAGTACTGC
CAGTCCAAAGGCATCGTGGTGACCGCCTACAGCCCCCTCGGCTCTCCTGACAGGCCCTGG
GCCAAGCCCGAGGACCCTTCTCTCCTGGAGGATCCCAGGATCAAGGCGATCGCAGCCAAG
CACAATAAAACTACAGCCCAGGTCCTGATCCGGTTCCCCATGCAGAGGAACTTGGTGGTG
ATCCCCAAGTCTGTGACACCAGAACGCATTGCTGAGAACTTTAAGGTCTTTGACTTTGAA
CTGAGCAGCCAGGATATGACCACCTTACTCAGCTACAACAGGAACTGGAGGGTCTGTGCC
TTGTTGAGCTGTACCTCCCACAAGGATTACCCCTTCCATGAAGAGTTTTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
J04795

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_1_Locus:
7q35

# Metabolic_Enzyme_1_SNPs:
rs5054; rs5060; rs5059; rs2229543; rs3087630; rs5055; rs5053; rs1790999; rs1790998; rs1646640; rs4732027; rs2734653; rs3896278; rs2734650; rs10954455; rs1708432; rs10808275; rs17660462; rs2670227; rs11974100; rs2734657; rs2670232; rs1424426; rs2734649; rs2551472; rs2259458; rs17188118; rs12669537; rs2734655; rs7778371; rs1708434; rs11971263; rs2670230; rs10273906; rs17167854; rs2734665; rs969309; rs2701020; rs2734663; rs2734664; rs706207; rs759853; rs17167851; rs918825; rs918824; rs11975656; rs17856148; rs11544687; rs5057; rs4728325; rs5061; rs5062; rs5056; rs17849987; rs1803093; rs3210035; rs11544690; rs13306160; rs1803094; rs1803095; rs2852171; rs2854854; rs2551469; rs3749434; rs2734661; rs2670231; rs2551471; rs1791000; rs2670240; rs2734659; rs2852165; rs2551476; rs3216672; rs2854849; rs7801237; rs2269068; rs10588800; rs35880193; rs2734658; rs34559471; rs2691837; rs1732035; rs2852170; rs2854853; rs2670239; rs1646639; rs2854851; rs5058; rs2551470; rs2670233; rs13306159; rs2854848; rs2701019; rs2734660; rs1732037; rs2852164; rs11417418; rs35431624; rs2852163; rs2269069; rs35632302; rs2852173; rs2854850; rs2551473; rs35338055; rs2691840; rs2852172; rs2734652; rs2852167; rs2854852; rs6963238; rs1791006; rs34569487; rs2670229; rs2551475; rs2691838; rs13306161; rs3216673; rs2974975; rs2551474; rs34678793; rs2551467; rs33945153; rs2852169; rs2734656; rs2854846; rs2734651; rs2691839; rs2734662; rs2852166; rs2691841; rs2551468; rs2691835; rs2551477; rs2691836; rs13306162; rs1708427; rs2852168; rs2670226; rs1621922; rs2852174; rs2551465; rs2691845; rs2551466; rs918826; rs35706999; rs2852176; rs2691846; rs1708404; rs12532832; rs1732039; rs1646636; rs1646642; rs1646637; rs2852175; rs1646641; rs10228986; rs10236262; rs10236468; rs10241645; rs10244489; rs10252030; rs10263438; rs10275865; rs11973239; rs13225343; rs1708414; rs1708415; rs1708416; rs17167841; rs1722900; rs1722911; rs1732038; rs1791001; rs2347375; rs2670228; rs6977866; rs706206; rs7802421; rs782054

# Metabolic_Enzyme_1_General_References:
2498333; 2504709; 2510130; 2111143; 2112546; 1901857; 9195951; 8435445; 2492527; 8343525; 8281941; 8245005; 1621098; 1447221; 8234324; 9405046

# Metabolic_Enzyme_1_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
5565

# Macromolecular_Interacting_Partner_1_Name:
GDH/6PGL endoplasmic bifunctional protein precursor [Includes: Glucose 1-dehydrogenase

# Macromolecular_Interacting_Partner_1_Synonyms:
Hexose-6-phosphate dehydrogenase; 6- phosphogluconolactonase; 6PGL]

# Macromolecular_Interacting_Partner_1_Gene_Name:
H6PD

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>GDH/6PGL endoplasmic bifunctional protein precursor Includes: Glucose 1dehydrogenase
MWNMLIVAMCLALLGCLQAQELQGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGRGHSF
SFHGAALTAPKQGQELMAKALESLSCPKDMAPSHCAEHKDQFLQLSQYRQLKTAEDYQAL
NKDIEAQLQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDH
FSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDGLWNRHHVERVEII
MKETVDAEGRTSFYEEYGVIRDVLQNHLTEVLTLVAMELPHNVSSAEAVLRHKLQVFQAL
RGLQRGSAVVGQYQSYSEQVRRELQKPDSFHSLTPTFAAVLVHIDNLRWEGVPFILMSGK
ALDERVGYARILFKNQACCVQSEKHWAAAQSQCLPRQLVFHIGHGDLGSPAVLVSRNLFR
PSLPSSWKEMEGPPGLRLFGSPLSDYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLL
ASWNFWTPLLESLAHKAPRLYPGGAENGRLLDFEFSSGRLFFSQQQPEQLVPGPGPAPMP
SDFQVLRAKYRESPLVSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQ
QLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHLLQHVRIPYYNIHPMPVHLQQ
RLCAEEDQGAQIYAREISALVANSSFDLVLLGMGADGHTASLFPQSPTGLDGEQLVVLTT
SPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLPHSGQL
VWYMDYDAFLG

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
791

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
88894

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.31

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  6-phosphogluconolactonase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  glucose-6-phosphate 1-dehydrogenase activity
 ||
>>>
Process:  glucose catabolism
Process:  pentose-phosphate shunt
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates

# Macromolecular_Interacting_Partner_1_Pathway:
map00030  Pentose phosphate pathway

# Macromolecular_Interacting_Partner_1_Reaction:
6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF02781:G6PD_C;
PF00479:G6PD_N;
PF01182:Glucosamine_iso

# Macromolecular_Interacting_Partner_1_Signals:
1-19

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 1.1.1.47;EC 3.1.1.31

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
4186038

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
G6PE_HUMAN (O95479)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
H6PD

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
H6PD

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:4795

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum lumen. Note=Microsomes, endoplasmic reticulum lumen

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>2376 bp
ATGTGGAATATGCTCATAGTGGCGATGTGCTTGGCCCTTCTGGGCTGCCTGCAAGCCCAG
GAGCTCCAGGGACATGTCTCCATAATCCTGCTGGGAGCAACTGGGGACCTGGCTAAGAAG
TACTTATGGCAGGGACTGTTCCAGCTGTACCTGGATGAAGCGGGGAGGGGTCACAGTTTT
AGCTTCCATGGAGCTGCTCTGACAGCCCCCAAGCAGGGTCAAGAGCTCATGGCCAAGGCC
CTGGAATCCCTCTCCTGCCCCAAGGACATGGCACCCAGTCACTGTGCAGAGCACAAGGAT
CAGTTCCTGCAGCTGAGCCAGTACCGCCAACTGAAGACGGCCGAGGACTATCAGGCCCTG
AACAAGGACATCGAGGCACAGCTCCAGCACGCAGGCCTCCGGGAGGCTGGCAGGATCTTC
TACTTCTCAGTGCCACCCTTCGCCTATGAAGACATTGCCCGCAACATCAACAGTAGCTGC
CGGCCAGGCCCGGGCGCCTGGCTGCGGGTTGTCCTTGAGAAACCCTTTGGCCATGACCAC
TTCTCAGCCCAGCAGCTGGCCACAGAACTCGGGACCTTTTTCCAGGAGGAGGAGATGTAC
CGGGTGGACCATTACTTAGGCAAGCAGGCTGTGGCGCAGATCCTGCCTTTCCGAGACCAG
AACCGCAAGGCTTTGGACGGCCTCTGGAACCGGCACCATGTGGAGCGGGTGGAGATCATC
ATGAAAGAGACCGTGGATGCTGAAGGCCGCACCAGCTTCTATGAGGAGTACGGTGTCATT
CGCGACGTCCTCCAGAACCATCTGACGGAGGTCCTCACCCTCGTGGCCATGGAGCTGCCC
CACAATGTCAGCAGTGCGGAGGCTGTGCTGCGGCACAAGCTTCAGGTCTTCCAGGCGCTG
CGGGGCCTGCAGAGGGGCAGTGCCGTCGTGGGCCAGTACCAGTCTTACAGTGAGCAGGTG
CGCAGAGAGCTGCAGAAGCCAGACAGCTTCCACAGCCTGACGCCGACCTTCGCAGGTGTC
CTAGTGCACATTGACAACCTTCGCTGGGAGGGCGTGCCTTTCATCCTGATGTCTGGCAAA
GCCTTGGACGAGAGAGTGGGCTACGCTCGGATCTTGTTCAAGAACCAGGCCTGCTGTGTG
CAGAGCGAAAAGCACTGGGCCGCGGCGCAGAGCCAGTGCCTGCCCCGGCAGCTCGTCTTC
CACATCGGCCATGGCGACCTGGGCAGCCCTGCCGTGCTGGTCAGCAGGAACCTGTTCAGG
CCCTCCCTGCCCTCCAGCTGGAAGGAAATGGAGGGACCACCTGGGCTCCGCCTTTTCGGC
AGCCCTCTGTCCGATTACTACGCCTACAGCCCTGTGCGGGAGCGGGACGCCCACTCCGTC
CTCTTATCCCATATCTTCCATGGCCGGAAGAATTTCTTCATCACCACAGAGAACTTGCTG
GCCTCCTGGAACTTCTGGACCCCTCTGCTGGAGAGCCTGGCCCATAAGGCCCCACGCCTC
TACCCTGGAGGAGCTGAGAATGGCCGTCTGTTGGACTTTGAGTTCAGTAGCGGCCGGTTG
TTCTTTTCCCAGCAGCAGCCGGAGCAGCTGGTGCCAGGGCCAGGGCCGGCCCCAATGCCC
AGTGACTTCCAGGTCCTCAGGGCCAAGTACCGAGAGAGCCCGCTGGTCTCCGCCTGGTCC
GAGGAGCTGATCTCTAAGCTGGCTAATGACATCGAGGCCACCGCTGTGCGAGCCGTGCGG
CGCTTTGGCCAGTTCCACCTGGCACTGTCGGGGGGCTCGAGCCCCGTGGCCCTGTTCCAG
CAGCTGGCCACGGCGCACTATGGCTTCCCCTGGGCCCACACGCACCTGTGGCTGGTTGAC
GAGCGCTGCGTCCCACTCTCAGACCCGGAGTCCAACTTCCAGGGCCTGCAGGCCCACCTG
CTGCAGCACGTCCGGATCCCCTACTACAACATCCACCCCATGCCTGTGCACCTGCAGCAG
CGGCTCTGCGCCGAGGAGGACCAGGGCGCCCAGATCTATGCCAGGGAGATCTCAGCCCTG
GTGGCCAACAGCAGCTTCGACCTGGTGCTGCTGGGCATGGGTGCCGACGGGCACACAGCC
TCCCTCTTCCCACAGTCACCCACTGGCCTGGATGGCGAGCAGCTGGTCGTGCTGACCACG
AGCCCCTCCCAGCCACACCGCCGCATGAGCCTTAGCCTGCCTCTCATCAACCGCGCCAAG
AAGGTGGCAGTCCTGGTCATGGGCAGGATGAAGCGTGAGATCACCACGCTGGTGAGCCGG
GTGGGCCATGAGCCCAAGAAGTGGCCCATCTCGGGTGTCCTGCCGCACTCCGGCCAGCTG
GTGTGGTACATGGACTACGACGCCTTCCTGGGATGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AJ012590

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_1_Locus:
1p36

# Macromolecular_Interacting_Partner_1_SNPs:
rs6688832; rs17368528; rs35404275; rs34603401; rs35525021; rs7524046; rs9434743; rs9434742; rs11121350; rs35301166; rs1294014; rs11807816; rs2268175; rs12314; rs1294015; rs2239561; rs2268176; rs11121354; rs11121356; rs17368633; rs11121355; rs2268173; rs2071931; rs9434747; rs17033642; rs1142687; rs11121349; rs12405956; rs6685399; rs4908830; rs1294011; rs9434745; rs9435159; rs9434729; rs12126056; rs2268172; rs11588606; rs1142672; rs2239560; rs732950; rs731183; rs3753165; rs1294010; rs3753164; rs2268169; rs3753163; rs2268170; rs6662509; rs11804534; rs763180; rs11809790; rs2310925; rs10864404; rs2311051; rs11806000; rs3765959; rs10864403; rs12082862; rs7526864; rs9435151; rs7514387; rs6577564; rs11801562; rs9434725; rs7522207; rs35610691; rs34274595; rs12118991; rs35668164; rs17368556; rs35511555; rs34580447; rs35863691; rs7412488; rs36094664; rs34082738; rs34448374; rs36058755; rs3207298; rs33954071; rs3207317; rs3752547; rs5772361; rs41280760; rs9434726; rs35833857; rs12728837; rs4908831; rs1065216; rs3207316; rs3057978; rs11588618; rs35071335; rs41280764; rs9435162; rs2268174; rs9435144; rs35341128; rs34967254; rs9435148; rs34715803; rs1142686; rs1142671; rs9435161; rs1138467; rs12144045; rs34078161; rs12403063; rs1138468; rs1142675; rs35486518; rs3206225; rs1142689; rs9435163; rs6697931; rs1294016; rs35600947; rs9434746; rs41280762; rs2268171; rs6658895; rs12040818; rs1142688; rs9435164; rs1142690; rs34854341; rs9434737; rs36065021; rs1294009; rs5772359; rs12039626; rs9435158; rs1890684; rs34931714; rs12076525; rs2097519; rs763179; rs28548609; rs28665681; rs34308839; rs12083129; rs10449320; rs3861753; rs9434736; rs12032814; rs11805951; rs9435152; rs34764359; rs28496367; rs35492379; rs9435156; rs9434732; rs11804519; rs3765958; rs5772358; rs9435155; rs12042692; rs9434738; rs743972; rs35063052; rs12039625; rs2185298; rs12738271; rs2095907; rs4601607; rs34149245; rs6680990; rs9435167; rs9435166; rs7523498; rs35587892; rs7523400; rs1003369; rs1004920; rs10489436; rs10746487; rs11590326; rs12072683; rs12093524; rs12093571; rs12403829; rs1294012; rs2097520; rs2105225; rs2871656; rs34870859; rs3753271; rs4908832; rs6688233; rs7517538; rs916379; rs916380; rs916381; rs916382; rs916383; rs916384; rs916385; rs916386; rs9434723; rs9435168; rs9435179; rs946599; rs946602

# Macromolecular_Interacting_Partner_1_General_References:
10349511

# Macromolecular_Interacting_Partner_1_References:
14711665

# Macromolecular_Interacting_Partner_2_ID:
8240

# Macromolecular_Interacting_Partner_2_Name:
Xylulose kinase

# Macromolecular_Interacting_Partner_2_Synonyms:
Xylulokinase

# Macromolecular_Interacting_Partner_2_Gene_Name:
XYLB

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Xylulose kinase
MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGHVLDVHGVHVHKD
GLTVTSPVLMWVQALDIILEKMKASGFEFSQVLALSGAGQQHGSIYWKAGAQQALTSLSP
DLRLHQQLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIA
KIYQQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGAC
APHLEEKLSPPVPSCSVVGAISSYNVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIAV
SLGTSDTLFLWLQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSD
FSKALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEVRALIEGQFM
AKRIHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRA
FHGLAGGTDVPFSEVVKLAPNPRLAATPSPGASQVRDHXNLFVAFAL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
527

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
57320

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.91

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_2_Specific_Function:
ATP + D-xylulose = ADP + D-xylulose 5- phosphate

# Macromolecular_Interacting_Partner_2_Pathway:
map00040  Pentose and glucuronate interconversions

# Macromolecular_Interacting_Partner_2_Reaction:
ATP + D-xylulose = ADP + D-xylulose 5-phosphate

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF02782:FGGY_C;
PF00370:FGGY_N

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
EC 2.7.1.17

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
3298502

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
XYLB_HUMAN (O75191)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
XYLB

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
XYLB

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:12839

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1584 bp
ATGGCGGAGCACGCCCCTCGCCGCTGCTGCCTGGGCTGGGACTTCAGCACGCAGCAGGTA
AAGGTTGTTGCTGTTGATGCAGAGTTGAATGTCTTCTATGAGGAAAGTGTGCATTTTGAC
AGAGATCTTCCAGAATTTGGGCATGTACTTGATGTGCATGGTGTTCATGTGCACAAGGAT
GGGCTGACGGTCACTTCTCCAGTACTAATGTGGGTCCAGGCACTGGATATCATCTTGGAG
AAGATGAAGGCTTCGGGCTTCGAATTCTCTCAAGTCCTAGCCTTGTCCGGGGCGGGCCAG
CAACACGGAAGTATATACTGGAAGGCTGGAGCCCAGCAGGCACTGACAAGCTTATCACCA
GACCTCCGGCTACACCAGCAGCTTCAGGACTGTTTCTCCATCAGCGACTGCCCGGTGTGG
ATGGACTCCAGCACCACAGCCCAGTGCCGCCAGCTGGAGGCTGCTGTGGGTGGTGCTCAG
GCTCTCAGCTGCCTCACGGGGTCCCGTGCCTATGAGCGTTTTACAGGGAACCAAATTGCA
AAAATTTACCAGCAGAACCCCGAGGCCTACTCACATACAGAGAGAATTTCTTTGGTCAGT
AGCTTTGCTGCTTCCCTGTTCCTTGGCTCTTACTCCCCTATTGACTACAGTGATGGTTCT
GGAATGAATTTGTTGCAGATACAGGATAAAGTCTGGTCCCAGGCTTGCCTTGGTGCCTGT
GCACCTCATTTAGAGGAGAAGCTTAGCCCACCAGTACCATCATGCTCAGTTGTGGGAGCC
ATTTCTTCCTACAACGTCCAGCGCTACGGATTTCCTCCAGGATGCAAAGTGGTGGCCTTC
ACTGGGGACAACCCAGCGTCGCTGGCAGGCATGAGACTGGAGGAAGGTGACATTGCGGTC
AGCCTGGGCACCAGTGACACCCTGTTTCTCTGGCTCCAAGAGCCCATGCCTGCCCTGGAA
GGCCACATCTTCTGCAACCCGGTTGACTCCCAGCACTACATGGCACTCCTGTGCTTTAAA
AATGGCTCCCTCATGAGAGAGAAGATCCGCAACGAGTCTGTATCCCGTTCCTGGAGCGAT
TTCTCTAAGGCACTGCAGTCCACAGAGATGGGCAACGGTGGAAACCTGGGTTTTTATTTT
GATGTAATGGAGATCACCCCTGAAATTATTGGACGTCATAGGTTTAACACAGAAAACCAC
AAGGTTGCAGCATTCCCTGGGGATGTGGAGGTTCGAGCACTAATTGAAGGACAATTCATG
GCCAAGAGGATTCACGCAGAAGGCCTGGGCTATCGAGTCATGTCCAAGACAAAGATTTTG
GCCACAGGAGGAGCATCTCACAATAGAGAAATCTTACAGGTGCTTGCAGATGTGTTTGAT
GCCCCGGTGTATGTTATAGACACTGCCAACTCGGCCTGTGTGGGTTCTGCATACCGAGCT
TTTCATGGTCTTGCAGGTGGAACAGATGTGCCCTTTTCAGAGGTTGTGAAGTTAGCTCCA
AATCCCAGACTAGCTGCTACCCCAAGCCCGGGAGCTTCTCAGGTGAGAGACCATCNGAAT
TTGTTTGTAGCATTTGCATTATGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AB015046

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_2_Locus:
3p22-p21.3

# Macromolecular_Interacting_Partner_2_SNPs:
rs17118; rs2234610; rs2234622; rs704943; rs843890; rs149290; rs7373805; rs7373930; rs13074025; rs13074160; rs12636358; rs17037658; rs704951; rs704936; rs2070488; rs149741; rs1002676; rs818840; rs196381; rs196377; rs704939; rs704941; rs818851; rs2169552; rs169045; rs2070486; rs704950; rs843942; rs818833; rs1381798; rs704946; rs4678603; rs7372452; rs2070487; rs4678604; rs1858740; rs151617; rs704945; rs2070988; rs1069267; rs196376; rs1093685; rs151618; rs818837; rs17037638; rs11917976; rs17733640; rs818834; rs6809970; rs704954; rs818848; rs2588453; rs1093691; rs818841; rs2067082; rs2234617; rs13064938; rs704956; rs196375; rs7625693; rs169044; rs1002675; rs17733255; rs818836; rs17037644; rs820296; rs1099933; rs2234608; rs818839; rs1069096; rs7433707; rs6781983; rs2234616; rs820292; rs1094002; rs704947; rs704940; rs1093686; rs2126534; rs564242; rs6780924; rs11710235; rs818842; rs11129788; rs818835; rs1093684; rs509627; rs6771490; rs521479; rs818843; rs6799458; rs2070989; rs1663442; rs704942; rs847879; rs818829; rs196382; rs1093688; rs2234618; rs6781663; rs13088915; rs13081365; rs9876102; rs547554; rs9831851; rs12631092; rs818830; rs7372478; rs2234621; rs818844; rs820297; rs2234628; rs1094003; rs704937; rs3828443; rs820298; rs9861852; rs818832; rs196383; rs2268751; rs1093687; rs13069588; rs818849; rs506525; rs2234620; rs196378; rs704952; rs182022; rs2234612; rs2844435; rs1093693; rs1093692; rs704938; rs818845; rs1093689; rs6776469; rs13095158; rs196374; rs196356; rs704944; rs13089394; rs704949; rs13074866; rs2588455; rs2284815; rs2669607; rs2070987; rs9866290; rs7372922; rs6771945; rs485043; rs3111672; rs521483; rs9799098; rs818846; rs4678605; rs818838; rs818831; rs818847; rs11922285; rs196385; rs6771715; rs3792526; rs704948; rs13095391; rs9798893; rs13094878; rs4147024; rs4147025; rs2234600; rs580454; rs2234598; rs2234597; rs2234627; rs151611; rs196380; rs2234625; rs2234611; rs17854787; rs1858741; rs818850; rs2517967; rs35830629; rs2669617; rs34463945; rs7639629; rs4019744; rs848166; rs9860433; rs196387; rs1093690; rs2844432; rs36133725; rs34227037; rs6771611; rs5848421; rs34871515; rs11280242; rs494855; rs35576219; rs562943; rs6147778; rs13093125; rs2517969; rs2844437; rs28726359; rs182024; rs10624872; rs10648883; rs766989; rs2234614; rs13096802; rs2268752; rs3016006; rs1069097; rs28595637; rs2886579; rs865328; rs2234623; rs2517971; rs2517970; rs34185904; rs5848426; rs196372; rs34752434; rs7637422; rs34326656; rs847111; rs34045565; rs10610133; rs11379464; rs34334388; rs151614; rs34730668; rs34805045; rs34847699; rs196386; rs196391; rs196388; rs35564654; rs2234606; rs196379; rs35940894; rs6599151; rs863679; rs28444308; rs28470623; rs35616892; rs2669618; rs5848422; rs35785939; rs35772450; rs36060859; rs13070129; rs35787003; rs848163; rs2588461; rs35960235; rs196367; rs5848417; rs35091896; rs35127390; rs2234613; rs3132439; rs35509011; rs36095381; rs9880392; rs36144213; rs13318812; rs2844434; rs149740; rs28528210; rs2669606; rs34180911; rs2234624; rs3749385; rs4019743; rs34870569; rs28707243; rs35154536; rs35456017; rs34918180; rs35314448; rs6771827; rs2234609; rs2615630; rs28415377; rs11375257; rs34520124; rs36006807; rs35440594; rs861045; rs2588454; rs2844438; rs507637; rs704953; rs3094224; rs196357; rs35138251; rs4988961; rs2669619; rs514725; rs5848427; rs35671901; rs848165; rs2844433; rs1069266; rs36006749; rs35801122; rs35874348; rs196371; rs151615; rs35192788; rs562851; rs169047; rs10639762; rs861767; rs516147; rs847226; rs11452246; rs196366; rs526142; rs196369; rs169042; rs187813; rs2234605; rs13086899; rs36078825; rs9811714; rs185507; rs35789966; rs5848423; rs3132440; rs13088419; rs2517968; rs553967; rs35085866; rs35513842; rs196389; rs11311585; rs484620; rs35553573; rs36175068; rs28613567; rs35336888; rs36171697; rs35639653; rs493880; rs35588129; rs2844436; rs151616; rs196384; rs6771940; rs494857; rs11707201; rs33940246; rs11280504; rs196365; rs10581895; rs151613; rs12636622; rs2615631; rs34375202; rs847225; rs2234604; rs10049137; rs36153447; rs36159229; rs35446297; rs196370; rs35098138; rs4019742; rs1617147; rs2234619; rs6800267; rs182023; rs11707104; rs35017445; rs2588452; rs35391839; rs10542975; rs13089362; rs6791689; rs35508778; rs169046; rs9870665; rs34652378; rs2366116; rs2234626; rs515470; rs35009789; rs6781534; rs5848418; rs2234607; rs524313; rs1104096; rs558876; rs34144600; rs4019745; rs10666291; rs36119747; rs5848424; rs2234615; rs5848425; rs2588460; rs7637423; rs196390; rs5848419; rs865870; rs1783502; rs10717157; rs34701679; rs35593230; rs12330510; rs515879; rs2517972; rs847224; rs196358; rs196368; rs35139989; rs2234603; rs9832998; rs196373; rs35336352; rs5848420; rs2669624; rs3106454; rs515724; rs2669625; rs2234599; rs35276912; rs2234595; rs2234602; rs10546134; rs2234596; rs13326934; rs2234601; rs3106453; rs35383875; rs13085153; rs13092164; rs13092473; rs2517965; rs2588456; rs2615634; rs2615635; rs2615636; rs2844431; rs3845957; rs6806209; rs6807940

# Macromolecular_Interacting_Partner_2_General_References:
Not Available

# Macromolecular_Interacting_Partner_2_References:
12811467; 15727825

# Macromolecular_Interacting_Partner_3_ID:
7954

# Macromolecular_Interacting_Partner_3_Name:
Xylosidase

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
XBX1

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Xylosidase
AYSRAGATXGTISTPVRLTGXCRPCAFRSTTPXGXLTXRPGFLRLYGXDSLNSXFXQSXV
ARRXQHFAFRAETRMEFSPVHFQQSXGLTCYYNSKNWSYCFVDYEEGQGRTIKVIQLDHN
VPSWPLH

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
127

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
13828

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
9.55

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_3_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
3560476

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
O76044_HUMAN (O76044)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
XBX1

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
XBX1

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:12803

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>381 bp
GCCTACAGCCGTGCCGGGGCAACTGNCGGGACGATTTCGACGCCAGTTCGCTTGACNGGG
ANCTGCAGACCCTGCGCATTCCGTTCGACGACACCCTNGGGCTNGCTCACNNCNCGACCG
GGCTTCTTACGGCTCTATGGCANCGACTCGCTCAATTCGNCCTTCANCCAATCGNCCGTG
GCGCGCCGCTGNCAGCACTTCGCCTTCCGGGCAGAAACGCGGATGGAGTTCTCGCCGGTG
CACTTCCAGCAGAGCNCGGGGCTGACCTGCTACTACAACAGCAAAAACTGGAGCTACTGC
TTTGTGGACTACGAGGAGGGACAGGGTAGAACCATCAAAGTTATCCAGCTCGACCACAAC
GTACCGTCGTGGCCGCTGCAC

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
U88969

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_3_Locus:
1p36.3

# Macromolecular_Interacting_Partner_3_SNPs:
Not Available

# Macromolecular_Interacting_Partner_3_General_References:
9653645

# Macromolecular_Interacting_Partner_3_References:
14761997

# Macromolecular_Interacting_Partner_4_ID:
8080

# Macromolecular_Interacting_Partner_4_Name:
Beta-nerve growth factor precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
Beta-NGF

# Macromolecular_Interacting_Partner_4_Gene_Name:
NGFB

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Betanerve growth factor precursor
MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIA
ARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSK
RSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCR
DPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRR
A

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
241

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
26959

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
10.54

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00243:NGF

# Macromolecular_Interacting_Partner_4_Signals:
1-18

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
671883

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
NGF_HUMAN (P01138)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
NGFB

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
NGFB

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:7808

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>726 bp
ATGTCCATGTTGTTCTACACTCTGATCACAGCTTTTCTGATCGGCATACAGGCGGAACCA
CACTCAGAGAGCAATGTCCCTGCAGGACACACCATCCCCCAAGTCCACTGGACTAAACTT
CAGCATTCCCTTGACACTGCCCTTCGCAGAGCCCGCAGCGCCCCGGCAGCGGCGATAGCT
GCACGCGTGGCGGGGCAGACCCGCAACATTACTGTGGACCCCAGGCTGTTTAAAAAGCGG
CGACTCCGTTCACCCCGTGTGCTGTTTAGCACCCAGCCTCCCCGTGAAGCTGCAGACACT
CAGGATCTGGACTTCGAGGTCGGTGGTGCTGCCCCCTTCAACAGGACTCACAGGAGCAAG
CGGTCATCATCCCATCCCATCTTCCACAGGGGCGAATTCTCGGTGTGTGACAGTGTCAGC
GTGTGGGTTGGGGATAAGACCACCGCCACAGACATCAAGGGCAAGGAGGTGATGGTGTTG
GGAGAGGTGAACATTAACAACAGTGTATTCAAACAGTACTTTTTTGAGACCAAGTGCCGG
GACCCAAATCCCGTTGACAGCGGGTGCCGGGGCATTGACTCAAAGCACTGGAACTCATAT
TGTACCACGACTCACACCTTTGTCAAGGCGCTGACCATGGATGGCAAGCAGGCTGCCTGG
CGGTTTATCCGGATAGATACGGCCTGTGTGTGTGTGCTCAGCAGGAAGGCTGTGAGAAGA
GCCTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
V01511

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_4_Locus:
1p13.1

# Macromolecular_Interacting_Partner_4_SNPs:
rs6330; rs11466110; rs11466111; rs6325; rs1318345; rs2747058; rs719452; rs2179926; rs2254404; rs2856813; rs910330; rs2239622; rs10776800; rs2254527; rs3811015; rs4332358; rs10776798; rs4454548; rs4839028; rs4073129; rs4076194; rs4839435; rs4146585; rs6678788; rs4839436; rs6326; rs12082544; rs6328; rs6698675; rs7540561; rs6537860; rs4240542; rs7544068; rs4529705; rs7542555; rs4075872; rs11102929; rs2747063; rs10745349; rs7535026; rs10776799; rs2268792; rs6673867; rs4565713; rs4626883; rs2268793; rs4076018; rs2300692; rs6331; rs6686615; rs10858075; rs12402406; rs11466098; rs17540656; rs4573519; rs10858072; rs10489530; rs12060354; rs7516191; rs11466100; rs11102924; rs7530686; rs3730194; rs2856811; rs10776797; rs12026714; rs11102925; rs17033706; rs7513144; rs4298728; rs17033692; rs17033685; rs10442682; rs11102919; rs12067817; rs4382725; rs4567277; rs3738701; rs11102917; rs11466085; rs11102926; rs7544163; rs7523654; rs17033688; rs10858074; rs4634908; rs2300694; rs7520839; rs11466069; rs11466104; rs11466091; rs11466073; rs4240543; rs11466103; rs11466089; rs11466083; rs11466102; rs12026809; rs11102920; rs12145726; rs12048019; rs11466076; rs11102916; rs11466070; rs10442681; rs6678898; rs11466068; rs11466075; rs12061479; rs7415422; rs11466099; rs7555016; rs11466093; rs6658541; rs11466077; rs17033622; rs11466079; rs11466095; rs2300693; rs11466094; rs4623700; rs10858071; rs11466106; rs11466109; rs12058002; rs11466097; rs11466074; rs3811016; rs12061661; rs17033680; rs2300695; rs11466108; rs4644491; rs11102922; rs4406631; rs12058927; rs11466072; rs12091513; rs12060360; rs11466071; rs4298730; rs11466081; rs11466086; rs10858073; rs11466080; rs11102921; rs11102927; rs7536097; rs12760036; rs11102918; rs11466087; rs11466096; rs11466084; rs4320778; rs11584438; rs4348722; rs4456091; rs4839434; rs6329; rs7417254; rs11466088; rs10158276; rs4240544; rs11466082; rs3811014; rs10776801; rs11102930; rs11466113; rs11466066; rs11466063; rs11466065; rs11466062; rs34542615; rs28758211; rs11466112; rs34079702; rs35941329; rs11466092; rs12727497; rs35833423; rs11579116; rs35290932; rs11302114; rs2284830; rs12749420; rs3730184; rs28645283; rs2747059; rs11466090; rs35070942; rs11102923; rs12088144; rs35067920; rs11102928; rs11580846; rs35755250; rs11466107; rs34024301; rs12023088; rs28735771; rs28461336; rs11579131; rs34357271; rs34257515; rs11579114; rs35884898; rs12025459; rs12119346; rs35221274; rs35274060; rs12073677; rs12070188; rs11584424; rs35329343; rs34377570; rs11485078; rs3730215; rs35658308; rs3021067; rs4417063; rs12731678; rs2747061; rs35447405; rs12047130; rs11579133; rs13374803; rs35225488; rs9970214; rs719451; rs7528234; rs2747056; rs2856814; rs10157426; rs12731680; rs11466078; rs2747055; rs35917469; rs35011726; rs35337130; rs35044546; rs17033682; rs28505352; rs34063775; rs2856812; rs35439338; rs11466105; rs34845120; rs11586039; rs34042023; rs35071824; rs34402529; rs2747057; rs11466114; rs35603764; rs11466064; rs11466061; rs11466067; rs34611363; rs3841009; rs10776802; rs10858076; rs10858077; rs10858078; rs11102915; rs11102932; rs11466059; rs11583020; rs11805062; rs11807499; rs12074502; rs12075799; rs12085129; rs12139760; rs12723944; rs1474798; rs1535093; rs1555207; rs17033589; rs17033597; rs17033602; rs17033725; rs2068797; rs2982740; rs2982741; rs2982742; rs3014804; rs4073110; rs4131272; rs4131273; rs4310443; rs4418592; rs4504888; rs4839029; rs4839030; rs4839031; rs6327; rs6656381; rs6657711; rs6676284; rs6678944; rs6691765; rs7416420; rs7523086; rs7523831; rs7532754; rs7544256; rs926781

# Macromolecular_Interacting_Partner_4_General_References:
6688123; 6327169; 2374737; 10322959; 2025430; 10391209

# Macromolecular_Interacting_Partner_4_References:
13680251

End of HMDB00098

Beginning of HMDB00099
# Accession_No:
HMDB00099

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-19 15:19:18

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Cystathionine

# Description:
Cystathionine is a dipeptide formed by serine and homocysteine. Cystathioninuria is a prominent manifestation of vitamin-B6 deficiency. The transsulfuration of methionine yields homocysteine, which combines with serine to form cystathionine, the proximate precursor of cysteine through the enzymatic activity of cystathionase. In conditions in which cystathionine gamma-synthase or cystathionase is deficient, for example, there is cystathioninuria. Although cystathionine has not been detected in normal human serum or plasma by most conventional methods, gas chromatographic/mass spectrometric methodology detected a mean concentration of cystathionine in normal human serum of 140 nM, with a range of 65 to 301 nM.567 Cystathionine concentrations in CSF have been 10, 1, and 0.5 uM, and "not detected." Only traces (i.e., <1 uM) of cystathionine are present in normal CSF.587.  gamma-Cystathionase deficiency provided the first instance in which, in a human, the major biochemical abnormality due to a defined enzyme defect was clearly shown to be alleviated by administration of large doses of pyridoxine. The response in gamma-cystathionase-deficient patients is not attributable to correction of a preexisting deficiency of this vitamin. (OMMBID, Chap. 88)

# Synonyms:
(R)-S-(2-amino-2-carboxyethyl)-L-Homocysteine; Cystathionine; L-(+)-Cystathionine; L-Cystathionine; [R-(R*,S*)]-2-amino-4-[(2-amino-2-carboxyethyl)thio]-Butanoate; [R-(R*,S*)]-2-amino-4-[(2-amino-2-carboxyethyl)thio]-Butanoic acid

# Chemical_IUPAC_Name:
S-(2-amino-2-carboxyethyl)-L-Homocysteine

# Chemical_Formula:
C7H14N2O4S

# Chemical_Structure:
tbl_chemical:::HMDB00099_ZOOM.png:::119283189423737256

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00099_THUMB.png:::119283189229428525

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
thioether; primary amine; primary aliphatic amine (alkylamine); carboxylic acid; alpha-aminoacid

# Taxonomy_Biofunction:
Component of Cysteine metabolism; Component of Glycine, serine and threonine metabolism; Component of Methionine metabolism; Component of Nitrogen metabolism; Component of Selenoamino acid metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
222.06744

# Molecular_Weight_Avg:
222.26207

# Smiles_String_isomeric:
N[C@@H](CCSCC(N)C(O)=O)C(O)=O

# Smiles_String_canonical:
NC(CCSCC(N)C(O)=O)C(O)=O

# KEGG_Compound_ID:
C00542

# BioCyc_ID:
L-CYSTATHIONINE

# PubChem_CID:
439258

# PubChem_SID:
10298271; 841793; 8144601; 3823

# OMIM_ID:
188050; 219500; 236200; 250940; 603174

# Metagene_ID:
HOMOCYSTINURIA. CYSTATHIONINE BETA-SYNTHASE DEFICIENCY: 185; gamma-CYSTATHIONASE DEFICIENCY (CTH): 102

# BiGG_ID:
39523

# Wikipedia_ID:
Cystathionine

# METLIN_ID:
39

# Ref_ID:
6885789; 11122323; 2026685; 8507876; 186155; 15585776; 5936154; 10338090; 500809; 4047345

# ChEBI_ID:
17755

# CAS_Registry_Number:
56-88-2

# InChI:
InChI=1/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5?/m0/s1

# Synthesis_Reference:
Immobilization of Saccharomyces cerevisiae cystathionine g-lyase and application of the product to cystathionine synthesis.     Yamagata, Shuzo; Akamatsu, Tsuyoshi; Iwama, Tomonori.    Department of Biotechnology, Faculty of Agriculture,  Gifu University,

# Melting_Point:
281 oC

# Melting_Point_predicted:
49.9 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
22 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
1000.0 mg/mL [MEYLAN,WM et al. (1996)]; 17.3 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-4.00 [Predicted by ALOGPS]; -5.4 [Predicted by PubChem via XLOGP]; -4.80 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Cystathionine.pdf:::1132562199918537853

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Cystathionine.mol:::1132723807078648973

# SDF_File_[Text]:
tbl_chemical:::HMDB00099.sdf:::119283188861672843

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00099.pdb:::119283189085728773

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::050111_P00_01_IS_1DP_noesy.png:::116890067138883641265

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::050111_P00_01_IS_1DP_presat.zip:::115204116736255290

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050111_P00_01_IS_1DP_Assigned.png:::115204116737797067

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050111_P00_01_IS.png:::117276694095951226

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050111_P00_01_IS.zip:::117276694102841922

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050111_P00_01_IS Assigned.png:::117276694377939163

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Cystathionine.gif:::1132732108578811086

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00099_peaks.txt:::1156309544119442724

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Cystathionine_C.gif:::113273768318421354

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00099_peaks.txt:::1156310734362575588

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00099L.png:::117555261951941218; Medium Energy:tbl_ms:::HMDB00099M.png:::117555267071476560; High Energy:tbl_ms:::HMDB00099H.png:::117555270927463027

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP)

# Tissue_Location:
Brain

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	1.84 (0.39-3.28)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Blood	6.65 (4.3-9.0)	uM	Children:1-13_yrs_old	Both	Normal	15585776
Blood	0.14 (0.08 - 0.24)	uM	Adult:>18_yrs_old	Both	Normal	11122323
Blood	1.0 (0.3-5.5)	umol/L	Newborn:0-30_days_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.


# Concentration_[Abnormal]:
Blood	2.14 (0.14 - 4.1)	uM	Adult:>18_yrs_old	Both	Folate Deficiency	8507876
Blood	1.56 (0.21 - 2.9)	uM	Adult:>18_yrs_old	Both	Cobalamin Deficiency	8507876


# Associated_Disorders:
Autism; Cobalamin Deficiency; Folate Deficiency; Gamma-Cystathionase Deficiency (CTH)

# Pathway_Names:
Methionine metabolism

# Pathway_Images:
Methionine_Metabolism.jpg

# KEGG_Images:
map00271

# Pathway_Graphs:
Methionine_Metabolism_Graph.jpg

# Pathway_SBMLs:
Methionine_Metabolism.xml

# Metabolic_Enzyme_1_ID:
6059

# Metabolic_Enzyme_1_Name:
Cystathionine beta-synthase

# Metabolic_Enzyme_1_Synonyms:
Serine sulfhydrase; Beta- thionase

# Metabolic_Enzyme_1_Gene_Name:
CBS

# Metabolic_Enzyme_1_Protein_Sequence:
>Cystathionine betasynthase
MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPSRCTWQLGRPA
SESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKD
RISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDV
LRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEI
LQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPEGSILAEPEELNQTEQTT
YEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKA
AQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLS
APLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVG
KVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLL
NFVAAQERDQK

# Metabolic_Enzyme_1_Number_of_Residues:
551

# Metabolic_Enzyme_1_Molecular_Weight:
60587

# Metabolic_Enzyme_1_Theoretical_pI:
6.63

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  lyase activity
Function:  carbon-oxygen lyase activity
Function:  hydro-lyase activity
Function:  cystathionine beta-synthase activity
Function:  catalytic activity
 ||
>>>
Process:  sulfur amino acid metabolism
Process:  sulfur amino acid biosynthesis
Process:  cysteine biosynthesis
Process:  cysteine biosynthesis via cystathione
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  L-serine metabolism
Process:  cysteine biosynthesis from serine
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
L-serine + L-homocysteine = L-cystathionine + H(2)O

# Metabolic_Enzyme_1_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00271  Methionine metabolism;
 map00450  Selenoamino acid metabolism

# Metabolic_Enzyme_1_Reaction:
L-serine + L-homocysteine = cystathionine + H2O

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00571:CBS;
PF00291:PALP

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 4.2.1.22

# Metabolic_Enzyme_1_GenBank_ID_Protein:
388716

# Metabolic_Enzyme_1_SwissProt_ID:
CBS_HUMAN (P35520)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
CBS

# Metabolic_Enzyme_1_Geneatlas_id:
CBS

# Metabolic_Enzyme_1_hgnc_id:
HGNC:1550

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm. Nucleus

# Metabolic_Enzyme_1_Gene_Sequence:
>1656 bp
ATGCCTTCTGAGACCCCCCAGGCAGAAGTGGGGCCCACAGGCTGCCCCCACCGCTCAGGG
CCACACTCGGCGAAGGGGAGCCTGGAGAAGGGGTCCCCAGAGGATAAGGAAGCCAAGGAG
CCCCTGTGGATCCGGCCCGATGCTCCGAGCAGGTGCACCTGGCAGCTGGGCCGGCCTGCC
TCCGAGTCCCCACATCACCACACTGCCCCGGCAAAATCTCCAAAAATCTTGCCAGATATT
CTGAAGAAAATCGGGGACACCCCTATGGTCAGAATCAACAAGATTGGGAAGAAGTTCGGC
CTGAAGTGTGAGCTCTTGGCCAAGTGTGAGTTCTTCAACGCGGGCGGGAGCGTGAAGGAC
CGCATCAGCCTGCGGATGATTGAGGATGCTGAGCGCGACGGGACGCTGAAGCCCGGGGAC
ACGATTATCGAGCCGACATCCGGGAACACCGGGATCGGGCTGGCCCTGGCTGCGGCAGTG
AGGGGCTATCGCTGCATCATCGTGATGCCAGAGAAGATGAGCTCCGAGAAGGTGGACGTG
CTGCGGGCACTGGGGGCTGAGATTGTGAGGACGCCCACCAATGCCAGGTTCGACTCCCCG
GAGTCACACGTGGGGGTGGCCTGGCGGCTGAAGAACGAAATCCCCAATTCTCACATCCTA
GACCAGTACCGCAACGCCAGCAACCCCCTGGCTCACTACGACACCACCGCTGATGAGATC
CTGCAGCAGTGTGATGGGAAGCTGGACATGCTGGTGGCTTCAGTGGGCACGGGCGGCACC
ATCACGGGCATTGCCAGGAAGCTGAAGGAGAAGTGTCCTGGATGCAGGATCATTGGGGTG
GATCCCGAAGGGTCCATCCTCGCAGAGCCGGAGGAGCTGAACCAGACGGAGCAGACAACC
TACGAGGTGGAAGGGATCGGCTACGACTTCATCCCCACGGTGCTGGACAGGACGGTGGTG
GACAAGTGGTTCAAGAGCAACGATGAGGAGGCGTTCACCTTTGCCCGCATGCTGATCGCG
CAAGAGGGGCTGCTGTGCGGTGGCAGTGCTGGCAGCACGGTGGCGGTGGCCGTGAAGGCT
GCGCAGGAGCTGCAGGAGGGCCAGCGCTGCGTGGTCATTCTGCCCGACTCAGTGCGGAAC
TACATGACCAAGTTCCTGAGCGACAGGTGGATGCTGCAGAAGGGCTTTCTGAAGGAGGAG
GACCTCACGGAGAAGAAGCCCTGGTGGTGGCACCTCCGTGTTCAGGAGCTGGGCCTGTCA
GCCCCGCTGACCGTGCTCCCGACCATCACCTGTGGGCACACCATCGAGATCCTCCGGGAG
AAGGGCTTCGACCAGGCGCCCGTGGTGGATGAGGCGGGGGTAATCCTGGGAATGGTGACG
CTTGGGAACATGCTCTCGTCCCTGCTTGCCGGGAAGGTGCAGCCGTCAGACCAAGTTGGC
AAAGTCATCTACAAGCAGTTCAAACAGATCCGCCTCACGGACACGCTGGGCAGGCTCTCG
CACATCCTGGAGATGGACCACTTCGCCCTGGTGGTGCACGAGCAGATCCAGTACCACAGC
ACCGGGAAGTCCAGTCAGCGGCAGATGGTGTTCGGGGTGGTCACCGCCATTGACTTGCTG
AACTTCGTGGCCGCCCAGGAGCGGGACCAGAAGTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
L19501

# Metabolic_Enzyme_1_Chromosome_Location:
Not Available

# Metabolic_Enzyme_1_Locus:
Not Available

# Metabolic_Enzyme_1_SNPs:
rs11700812; rs34040148; rs5742905; rs1801181; rs234706; rs2298758; rs706208; rs706209; rs12613; rs1051319; rs9982921; rs855780; rs9980564; rs4987122; rs2605308; rs2124459; rs6586283; rs2014564; rs2851391; rs2124458; rs234705; rs234715; rs2124460; rs6586281; rs2849729; rs4920037; rs2124461; rs234713; rs6586282; rs8132811; rs234712; rs11203172; rs2849727; rs234711; rs234709; rs397589; rs1789953; rs234714; rs11701048; rs234708; rs3788053; rs8132812; rs234707; rs11700992; rs3788051; rs760124; rs7276016; rs234702; rs9979325; rs3788050; rs35169520; rs36055171; rs34758144; rs2849728; rs9325622; rs9974224; rs4987123; rs2298759; rs35052117; rs234710; rs234704; rs13049958; rs3788052; rs9982015; rs35307078; rs35108415; rs1005584; rs35196215; rs11910385; rs1005585; rs12329764; rs1788484; rs13046827; rs2850144; rs11700748; rs17849313; rs28934892; rs34719150; rs28934891; rs2228298; rs34512829; rs34310920; rs2849731; rs855778; rs9978104; rs2850142; rs34462715; rs9983620; rs1803363; rs2850143; rs9980464; rs855779; rs34338239; rs35748451; rs1788467; rs855781; rs12626371; rs1051316; rs35560741; rs7276378; rs2895956; rs7279359; rs2298760; rs34540454; rs1788466; rs34612112; rs34035512; rs9975882; rs35158583; rs34345711; rs13046562; rs13051707; rs13052765; rs5844150; rs34966728; rs35491360; rs35034449; rs234701; rs9978861; rs13052774; rs10633769; rs34937797; rs11396320; rs13046552; rs34296490; rs2298761; rs34058998; rs34623684; rs35254159; rs13046893; rs35338183; rs2851392; rs13052870; rs34726873; rs33943377; rs10569459; rs13050450; rs13050197; rs8131163; rs34547320; rs35093797; rs8127973; rs2851393; rs234703; rs9978863; rs34612348; rs34210699; rs13046443; rs35957156; rs5844149; rs34528892; rs11552089; rs34718891; rs1788465; rs7278195; rs35990176; rs2244171; rs7279312; rs2849730; rs10599152; rs9637292; rs2850145; rs9637291; rs28825153; rs3045427; rs2276336; rs11909493; rs11911976; rs13047437; rs1515; rs1518; rs1672116; rs1672123; rs1672124; rs1672126; rs1788464; rs1788487; rs1788490; rs1809212; rs234783; rs234784; rs234785; rs2401191; rs2401192; rs2401194; rs2401195; rs28360502; rs2839631; rs2850146; rs373105; rs392225; rs3972; rs400660; rs411441; rs416943; rs418639; rs439944; rs440099; rs442259; rs466791; rs4919959; rs719037; rs719038; rs8127036; rs8128028; rs8133239; rs88483; rs897521; rs897522; rs915853

# Metabolic_Enzyme_1_General_References:
7903580; 7598711; 8022826; 9383285; 9790750; 681363; 11483494; 12173932; 10338090; 1301198; 8353501; 7506602; 7981678; 7849717; 7967489; 7611293; 7762555; 7635485; 8528202; 7564249; 8755636; 8803779; 9156316; 9361025; 8990018; 9266356; 10408774

# Metabolic_Enzyme_1_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
5789

# Macromolecular_Interacting_Partner_1_Name:
Cystathionine gamma-lyase

# Macromolecular_Interacting_Partner_1_Synonyms:
Gamma-cystathionase

# Macromolecular_Interacting_Partner_1_Gene_Name:
CTH

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Cystathionine gammalyase
MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEY
SRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRY
FRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHG
DIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQ
NSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQH
ELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVL
KNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
405

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
44508

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.69

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
L-cystathionine + H(2)O = L-cysteine + NH(3) + 2-oxobutanoate

# Macromolecular_Interacting_Partner_1_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00271  Methionine metabolism;
 map00272  Cysteine metabolism;
 map00450  Selenoamino acid metabolism;
 map00910  Nitrogen metabolism

# Macromolecular_Interacting_Partner_1_Reaction:
L-cystathionine + H2O = L-cysteine + ammonia + 2-oxobutanoate

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01053:Cys_Met_Meta_PP

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 4.4.1.1

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
262476

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
CGL_HUMAN (P32929)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
CTH

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
CTH

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:2501

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1218 bp
ATGCAGGAAAAAGACGCCTCCTCACAAGGTTTCCTGCCACACTTCCAACATTTCGCCACG
CAGGCGATCCATGTGGGCCAGGATCCGGAGCAATGGACCTCCAGGGCTGTAGTGCCCCCC
ATCTCACTGTCCACCACGTTCAAGCAAGGGGCGCCTGGCCAGCACTCGGGTTTTGAATAT
AGCCGTTCTGGAAATCCCACTAGGAATTGCCTTGAAAAAGCAGTGGCAGCACTGGATGGG
GCTAAGTACTGTTTGGCCTTTGCTTCAGGTTTAGCAGCCACTGTAACTATTACCCATCTT
TTAAAAGCAGGAGACCAAATTATTTGTATGGATGATGTGTATGGAGGTACAAACAGGTAC
TTCAGGCAAGTGGCATCTGAATTTGGATTAAAGATTTCTTTTGTTGATTGTTCCAAAATC
AAATTACTAGAGGCAGCAATTACACCAGAAACCAAGCTTGTTTGGATCGAAACCCCCACA
AACCCCACCCAGAAGGTGATTGACATTGAAGGCTGTGCACATATTGTCCATAAGCATGGA
GACATTATTTTGGTCGTGGATAACACTTTTATGTCACCATATTTCCAGCGCCCTTTGGCT
CTGGGAGCTGATATTTCTATGTATTCTGCAACAAAATACATGAATGGCCACAGTGATGTT
GTAATGGGCCTGGTGTCTGTTAATTGTGAAAGCCTTCATAATAGACTTCGTTTCTTGCAA
AACTCTCTTGGAGCAGTTCCATCTCCTATTGATTGTTACCTCTGCAATCGAGGTCTGAAG
ACTCTACATGTCCGAATGGAAAAGCATTTCAAAAACGGAATGGCAGTTGCCCAGTTCCTG
GAATCTAATCCTTGGGTAGAAAAGGTTATTTATCCTGGGCTGCCCTCTCATCCACAGCAT
GAGTTGGTGAAGCGTCAGTGTACAGGTTGTACAGGGATGGTCACCTTTTATATTAAGGGC
ACTCTTCAGCATGCTGAGATTTTCCTCAAGAACCTAAAGCTATTTACTCTGGCCGAGAGC
TTGGGAGGATTCGAAAGCCTTGCTGAGCTTCCGGCAATCATGACTCATGCATCAGTTCTT
AAGAATGACAGAGATGTCCTTGGAATTAGTGACACACTGATTCGACTTTCTGTGGGCTTA
GAGGATGAGGAAGACCTACTGGAAGATCTAGATCAAGCTTTGAAGGCAGCACACCCTCCA
AGTGGAATTCACAGCTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
S52784

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_1_Locus:
1p31.1

# Macromolecular_Interacting_Partner_1_SNPs:
rs1021737; rs17131292; rs535112; rs672203; rs663649; rs515064; rs473334; rs681475; rs481654; rs1145920; rs525919; rs6413469; rs4650049; rs525276; rs475263; rs12723350; rs543860; rs1145919; rs487773; rs490574; rs559062; rs501939; rs577476; rs6413471; rs482291; rs3767205; rs11800827; rs12047791; rs12566819; rs35173672; rs6413472; rs1831868; rs34538135; rs35523269; rs35441160; rs828355; rs17131305; rs35356635; rs608609; rs35864483; rs35242276; rs10889869; rs12037405; rs12030275; rs36032119; rs34044393; rs6413470; rs7418870; rs17131304; rs35873591; rs1831869; rs17131302; rs6693082; rs663465; rs648743; rs6677781; rs583316; rs6413468; rs12733999; rs3806385; rs17131290; rs584229; rs28595301; rs41305638; rs28498802; rs12134794; rs4650048; rs11295998; rs10583561; rs17131300; rs6703826; rs7367528; rs5775007; rs34806645; rs41313347; rs12134791; rs35200485; rs11589868; rs12134763; rs35769653; rs6657511; rs10607278; rs12141277; rs34046663; rs11413197; rs34328255; rs6657715; rs34566720; rs34937471; rs34141704; rs35782843; rs5775006; rs4323657; rs13374865; rs12134858; rs12753345; rs562660; rs6413473; rs4649915; rs12133065; rs35606808; rs35199704; rs12134857; rs12124009; rs34612780; rs34825234; rs36059149; rs34311111; rs34465384; rs36065609; rs11590089; rs11803055; rs12026422; rs12063280; rs12093763; rs12561944; rs12728599; rs1697388; rs17131275; rs17131276; rs17131277; rs17131278; rs17131280; rs17131282; rs17131285; rs17131286; rs17131287; rs17131288; rs17131289; rs17131312; rs2151540; rs3856027; rs3856028; rs4650047; rs4650050; rs482843; rs508310; rs517500; rs555671; rs561926; rs618531; rs6424386; rs649346; rs664051; rs7515490; rs7537371; rs7549628

# Macromolecular_Interacting_Partner_1_General_References:
1339280; 12574942

# Macromolecular_Interacting_Partner_1_References:
12631446; 15642325; 16197295; 1629286

End of HMDB00099

Beginning of HMDB00101
# Accession_No:
HMDB00101

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-14 12:12:15

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Deoxyadenosine

# Description:
Deoxyadenosine is a derivative of nucleoside adenosine. It is comprised of adenine attached to a deoxyribose moiety via a N9-glycosidic bond.  Deoxyribose differs from ribose by the absence of oxygen in the 3' position of its ribose ring.  Deoxyadenosine is a critical component of DNA.

# Synonyms:
1-(6-amino-9H-purin-9-yl)-1,2-dideoxy-b-D-Ribofuranose; 2'-Deoxyadenosine; 9-(2-Deoxy-b-D-erythro-pentofuranosyl)adenine; 9-(2-deoxy-b-D-erythro-pentofuranosyl)-9H-Purin-6-amine; 9-(2-deoxy-b-D-ribofuranosyl)-9H-Purin-6-amine; Adenine deoxyribonucleoside; Adenine deoxyribose; Adenyldeoxyriboside; DA; Deoxyadenosine; Desoxyadenosine; adenine-9 2-deoxy-b-D-erythro-Pentofuranoside; 1-(6-amino-9H-purin-9-yl)-1,2-dideoxy-beta-delta-Ribofuranose; 9-(2-Deoxy-beta-delta-erythro-pentofuranosyl)adenine; 9-(2-deoxy-beta-delta-erythro-pentofuranosyl)-9H-Purin-6-amine; 9-(2-deoxy-beta-delta-ribofuranosyl)-9H-Purin-6-amine; adenine-9 2-deoxy-beta-delta-erythro-Pentofuranoside; 1-(6-amino-9H-purin-9-yl)-1,2-dideoxy-beta-D-Ribofuranose; 9-(2-Deoxy-beta-D-erythro-pentofuranosyl)adenine; 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-9H-Purin-6-amine; 9-(2-deoxy-beta-D-ribofuranosyl)-9H-Purin-6-amine; adenine-9 2-deoxy-beta-D-erythro-Pentofuranoside

# Chemical_IUPAC_Name:
Adenine Deoxyribonucleoside

# Chemical_Formula:
C10H13N5O3

# Chemical_Structure:
tbl_chemical:::HMDB00101_ZOOM.png:::119283190435165296

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00101_THUMB.png:::119283190237013890

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; primary alcohol; secondary alcohol; primary amine; primary aromatic amine; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
DNA component

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
251.10184

# Molecular_Weight_Avg:
251.24191

# Smiles_String_isomeric:
NC1=NC=NC2=C1N=CN2[C@H]3C[C@H](O)[C@@H](CO)O3

# Smiles_String_canonical:
NC1=NC=NC2=C1N=CN2C3CC(O)C(CO)O3

# KEGG_Compound_ID:
C00559

# BioCyc_ID:
Not Available

# PubChem_CID:
13730

# PubChem_SID:
7885263; 8160350; 747931; 841362; 10551920; 819324; 832228; 157065; 610410; 8025203; 7886872; 3839; 3135652; 1572491; 8144219; 7885722

# OMIM_ID:
164050

# Metagene_ID:
Not Available

# BiGG_ID:
35352

# Wikipedia_ID:
Deoxyadenosine

# METLIN_ID:
3382

# Ref_ID:
6982786; 6332978; 6968502; 8097528; 8749261; 6601986; 10102915; 6147383; 9869364; 6969149; 6256765; 3020905; 6609529; 2790329

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
958-09-8

# InChI:
InChI=1/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1

# Synthesis_Reference:
 Journal of the American Chemical Society  (1959),  81  3967-74.

# Melting_Point:
189

# Melting_Point_predicted:
136.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
3.36 mg/mL [MEYLAN,WM et al. (1996)]; 10.7 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-0.55 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-0.94 [Predicted by ALOGPS]; -0.8 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Deoxyadenosine.mol:::1132723807156278109

# SDF_File_[Text]:
tbl_chemical:::HMDB00101.sdf:::119283189826344644

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00101.pdb:::119283190094266172

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041106_P00_01_HW_1DP_presat.png:::115515564845655268

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041106_P00_01_HW_1DP_PRESAT_1.zip:::114168375618924967

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041106_P00_01_HW_1DP_Assigned.png:::115644085155498647

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041106_P00_01_HW_2DHSQC_704.png:::114789957015335323

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041106_P00_01_HW_2DHSQC_704.zip:::114789957017868744

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041106_P00_01_HW_2DHSQC_704_Assigned.png:::116248871473660702

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Deoxyadenosine.gif:::1132732108781237434

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00101_peaks.txt:::1156309545142533018

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Deoxyadenosine_C.gif:::1132737683805391085

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00101_peaks.txt:::1156310735373909599

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Nucleus; Cytoplasm (Predicted from Solubility); Cytoplasm; Extracellular; lysosome

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Urine

# Concentration_[Normal]:
Urine	176.0 (167.0-185.0)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	10102915
Urine	0.22 +/- 0.09	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9869364


# Concentration_[Abnormal]:
Urine	205.0	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Adenosine deaminase (ADA; EC 3.5.4.4) deficiency.	10102915
Urine	3.7	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Adenosine Deaminase (ADA) Deficiency	9869364
Urine	< 0.01	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Adenosine Deaminase (ADA) Deficiency	9869364


# Associated_Disorders:
Adenosine Deaminase (ADA) Deficiency; Adenosine deaminase (ADA; EC 3.5.4.4) deficiency.

# Pathway_Names:
Pentose and glucuronate interconversions;Fructose and mannose metabolism;Galactose metabolism;Glycerolipid metabolism;Pyruvate metabolism

# Pathway_Images:
;fructose_metabolism.jpg;;;

# KEGG_Images:
map00040;map00051;map00052;map00561;map00620

# Pathway_Graphs:
;fructose_metabolism_Graph.jpg;;;

# Pathway_SBMLs:
;fructose_metabolism.xml;;;

# Metabolic_Enzyme_1_ID:
5320

# Metabolic_Enzyme_1_Name:
Aldose reductase

# Metabolic_Enzyme_1_Synonyms:
AR; Aldehyde reductase

# Metabolic_Enzyme_1_Gene_Name:
AKR1B1

# Metabolic_Enzyme_1_Protein_Sequence:
>Aldose reductase
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF

# Metabolic_Enzyme_1_Number_of_Residues:
316

# Metabolic_Enzyme_1_Molecular_Weight:
35854

# Metabolic_Enzyme_1_Theoretical_pI:
6.99

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies

# Metabolic_Enzyme_1_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism

# Metabolic_Enzyme_1_Reaction:
alditol + NAD(P)+ = aldose + NAD(P)H + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.1.1.21

# Metabolic_Enzyme_1_GenBank_ID_Protein:
178487

# Metabolic_Enzyme_1_SwissProt_ID:
ALDR_HUMAN (P15121)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
AKR1B1

# Metabolic_Enzyme_1_Geneatlas_id:
AKR1B1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:381

# Metabolic_Enzyme_1_PDB_ID:
1T40

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>951 bp
ATGGCAAGCCGTCTCCTGCTCAACAACGGCGCCAAGATGCCCATCCTGGGGTTGGGTACC
TGGAAGTCCCCTCCAGGGCAGGTGACTGAGGCCGTGAAGGTGGCCATTGACGTCGGGTAC
CGCCACATCGACTGTGCCCATGTGTACCAGAATGAGAATGAGGTGGGGGTGGCCATTCAG
GAGAAGCTCAGGGAGCAGGTGGTGAAGCGTGAGGAGCTCTTCATCGTCAGCAAGCTGTGG
TGCACGTACCATGAGAAGGGCCTGGTGAAAGGAGCCTGCCAGAAGACACTCAGCGACCTG
AAGCTGGACTACCTGGACCTCTACCTTATTCACTGGCCGACTGGCTTTAAGCCTGGGAAG
GAATTTTTCCCATTGGATGAGTCGGGCAATGTGGTTCCCAGTGACACCAACATTCTGGAC
ACGTGGGCGGCCATGGAAGAGCTGGTGGATGAAGGGCTGGTGAAAGCTATTGGCATCTCC
AACTTCAACCATCTCCAGGTGGAGATGATCTTAAACAAACCTGGCTTGAAGTATAAGCCT
GCAGTTAACCAGATTGAGTGCCACCCATATCTCACTCAGGAGAAGTTAATCCAGTACTGC
CAGTCCAAAGGCATCGTGGTGACCGCCTACAGCCCCCTCGGCTCTCCTGACAGGCCCTGG
GCCAAGCCCGAGGACCCTTCTCTCCTGGAGGATCCCAGGATCAAGGCGATCGCAGCCAAG
CACAATAAAACTACAGCCCAGGTCCTGATCCGGTTCCCCATGCAGAGGAACTTGGTGGTG
ATCCCCAAGTCTGTGACACCAGAACGCATTGCTGAGAACTTTAAGGTCTTTGACTTTGAA
CTGAGCAGCCAGGATATGACCACCTTACTCAGCTACAACAGGAACTGGAGGGTCTGTGCC
TTGTTGAGCTGTACCTCCCACAAGGATTACCCCTTCCATGAAGAGTTTTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
J04795

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_1_Locus:
7q35

# Metabolic_Enzyme_1_SNPs:
rs5054; rs5060; rs5059; rs2229543; rs3087630; rs5055; rs5053; rs1790999; rs1790998; rs1646640; rs4732027; rs2734653; rs3896278; rs2734650; rs10954455; rs1708432; rs10808275; rs17660462; rs2670227; rs11974100; rs2734657; rs2670232; rs1424426; rs2734649; rs2551472; rs2259458; rs17188118; rs12669537; rs2734655; rs7778371; rs1708434; rs11971263; rs2670230; rs10273906; rs17167854; rs2734665; rs969309; rs2701020; rs2734663; rs2734664; rs706207; rs759853; rs17167851; rs918825; rs918824; rs11975656; rs17856148; rs11544687; rs5057; rs4728325; rs5061; rs5062; rs5056; rs17849987; rs1803093; rs3210035; rs11544690; rs13306160; rs1803094; rs1803095; rs2852171; rs2854854; rs2551469; rs3749434; rs2734661; rs2670231; rs2551471; rs1791000; rs2670240; rs2734659; rs2852165; rs2551476; rs3216672; rs2854849; rs7801237; rs2269068; rs10588800; rs35880193; rs2734658; rs34559471; rs2691837; rs1732035; rs2852170; rs2854853; rs2670239; rs1646639; rs2854851; rs5058; rs2551470; rs2670233; rs13306159; rs2854848; rs2701019; rs2734660; rs1732037; rs2852164; rs11417418; rs35431624; rs2852163; rs2269069; rs35632302; rs2852173; rs2854850; rs2551473; rs35338055; rs2691840; rs2852172; rs2734652; rs2852167; rs2854852; rs6963238; rs1791006; rs34569487; rs2670229; rs2551475; rs2691838; rs13306161; rs3216673; rs2974975; rs2551474; rs34678793; rs2551467; rs33945153; rs2852169; rs2734656; rs2854846; rs2734651; rs2691839; rs2734662; rs2852166; rs2691841; rs2551468; rs2691835; rs2551477; rs2691836; rs13306162; rs1708427; rs2852168; rs2670226; rs1621922; rs2852174; rs2551465; rs2691845; rs2551466; rs918826; rs35706999; rs2852176; rs2691846; rs1708404; rs12532832; rs1732039; rs1646636; rs1646642; rs1646637; rs2852175; rs1646641; rs10228986; rs10236262; rs10236468; rs10241645; rs10244489; rs10252030; rs10263438; rs10275865; rs11973239; rs13225343; rs1708414; rs1708415; rs1708416; rs17167841; rs1722900; rs1722911; rs1732038; rs1791001; rs2347375; rs2670228; rs6977866; rs706206; rs7802421; rs782054

# Metabolic_Enzyme_1_General_References:
2498333; 2504709; 2510130; 2111143; 2112546; 1901857; 9195951; 8435445; 2492527; 8343525; 8281941; 8245005; 1621098; 1447221; 8234324; 9405046

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5805

# Metabolic_Enzyme_2_Name:
Purine nucleoside phosphorylase

# Metabolic_Enzyme_2_Synonyms:
Inosine phosphorylase; PNP

# Metabolic_Enzyme_2_Gene_Name:
NP

# Metabolic_Enzyme_2_Protein_Sequence:
>Purine nucleoside phosphorylase
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS

# Metabolic_Enzyme_2_Number_of_Residues:
289

# Metabolic_Enzyme_2_Molecular_Weight:
32118

# Metabolic_Enzyme_2_Theoretical_pI:
6.95

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  purine-nucleoside phosphorylase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_2_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_2_Reaction:
purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00896:Mtap_PNP

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.4.2.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
35565

# Metabolic_Enzyme_2_SwissProt_ID:
PNPH_HUMAN (P00491)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
NP

# Metabolic_Enzyme_2_Geneatlas_id:
NP

# Metabolic_Enzyme_2_hgnc_id:
HGNC:7892

# Metabolic_Enzyme_2_PDB_ID:
1RT9

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>870 bp
ATGGAGAACGGATACACCTATGAAGATTATAAGAACACTGCAGAATGGCTTCTGTCTCAT
ACTAAGCACCGACCTCAAGTTGCAATAATCTGTGGTTCTGGATTAGGAGGTCTGACTGAT
AAATTAACTCAGGCCCAGATCTTTGACTACAGTGAAATCCCCAACTTTCCTCGAAGTACA
GTGCCAGGTCATGCTGGCCGACTGGTGTTTGGGTTCCTGAATGGCAGGGCCTGTGTGATG
ATGCAGGGCAGGTTCCACATGTATGAAGGGTACCCACTCTGGAAGGTGACATTCCCAGTG
AGGGTTTTCCACCTTCTGGGTGTGGACACCCTGGTAGTCACCAATGCAGCAGGAGGGCTG
AACCCCAAGTTTGAGGTTGGAGATATCATGCTGATCCGTGACCATATCAACCTACCTGGT
TTCAGTGGTCAGAACCCTCTCAGAGGGCCCAATGATGAAAGGTTTGGAGATCGTTTCCCT
GCCATGTCTGATGCCTACGACCGGACTATGAGGCAGAGGGCTCTCAGTACCTGGAAACAA
ATGGGGGAGCAACGTGAGCTACAGGAAGGCACCTATGTGATGGTGGCAGGCCCCAGCTTT
GAGACTGTGGCAGAATGTCGTGTGCTGCAGAAGCTGGGAGCAGACGCTGTTGGCATGAGT
ACAGTACCAGAAGTTATCGTTGCACGGCACTGTGGACTTCGAGTCTTTGGCTTCTCACTC
ATCACTAACAAGGTCATCATGGATTATGAAAGCCTGGAGAAGGCCAACCATGAAGAAGTC
TTAGCAGCTGGCAAACAAGCTGCACAGAAATTGGAACAGTTTGTCTCCATTCTTATGGCC
AGCATTCCACTCCCTGACAAAGCCAGTTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X00737

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_2_Locus:
14q13.1

# Metabolic_Enzyme_2_SNPs:
rs1049564; rs1130650; rs1049562; rs7785; rs1617940; rs1760940; rs1713420; rs1760935; rs1713422; rs1713421; rs3790064; rs3790065; rs1713429; rs17882804; rs17880405; rs1756369; rs12147688; rs8008133; rs17881431; rs17881345; rs7154909; rs17883821; rs17885781; rs1760934; rs17879107; rs17880844; rs17879913; rs17881184; rs17885714; rs17880480; rs17883253; rs17878900; rs1713426; rs17881356; rs1713427; rs1760933; rs3790062; rs17883795; rs17112168; rs17880290; rs12147906; rs17881554; rs17881206; rs1049700; rs17882836; rs12101049; rs17884106; rs12147035; rs34480769; rs3838361; rs3842517; rs1760939; rs17885917; rs17886095; rs1760938; rs17883294; rs17883604; rs8019880; rs17881280; rs35549071; rs35139440; rs17880503; rs7151666; rs10498268; rs1079375; rs1079376; rs11846743; rs11850059; rs11850069; rs12587218; rs12886203; rs12888804; rs12891271; rs13379232; rs13379234; rs1629478; rs17112384; rs17112385; rs1713459; rs1713460; rs1713461; rs1713462; rs17242655; rs17242662; rs17242669; rs1756365; rs1760930; rs1760931; rs1760941; rs1760942; rs2077153; rs2481768; rs35175606; rs35567022; rs7156659; rs755777

# Metabolic_Enzyme_2_General_References:
6087295; 3029074; 12928150; 2104852; 1384322; 8931706

# Metabolic_Enzyme_2_References:
8335625; 8521855; 9213430

# Metabolic_Enzyme_3_ID:
5937

# Metabolic_Enzyme_3_Name:
Adenosine deaminase

# Metabolic_Enzyme_3_Synonyms:
Adenosine aminohydrolase

# Metabolic_Enzyme_3_Gene_Name:
ADA

# Metabolic_Enzyme_3_Protein_Sequence:
>Adenosine deaminase
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL

# Metabolic_Enzyme_3_Number_of_Residues:
363

# Metabolic_Enzyme_3_Molecular_Weight:
40765

# Metabolic_Enzyme_3_Theoretical_pI:
5.80

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  adenosine deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_3_Specific_Function:
Adenosine + H(2)O = inosine + NH(3)

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_3_Reaction:
adenosine + H2O = inosine + ammonia

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.5.4.4

# Metabolic_Enzyme_3_GenBank_ID_Protein:
28380

# Metabolic_Enzyme_3_SwissProt_ID:
ADA_HUMAN (P00813)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ADA

# Metabolic_Enzyme_3_Geneatlas_id:
ADA

# Metabolic_Enzyme_3_hgnc_id:
HGNC:186

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_3_Gene_Sequence:
>1092 bp
ATGGCCCAGACGCCCGCCTTCGACAAGCCCAAAGTAGAACTGCATGTCCACCTAGACGGA
TCCATCAAGCCTGAAACCATCTTATACTATGGCAGGAGGAGAGGGATCGCCCTCCCAGCT
AACACAGCAGAGGGGCTGCTGAACGTCATTGGCATGGACAAGCCGCTCACCCTTCCAGAC
TTCCTGGCCAAGTTTGACTACTACATGCCTGCTATCGCGGGCTGCCGGGAGGCTATCAAA
AGGATCGCCTATGAGTTTGTAGAGATGAAGGCCAAAGAGGGCGTGGTGTATGTGGAGGTG
CGGTACAGTCCGCACCTGCTGGCCAACTCCAAAGTGGAGCCAATCCCCTGGAACCAGGCT
GAAGGGGACCTCACCCCAGACGAGGTGGTGGCCCTAGTGGGCCAGGGCCTGCAGGAGGGG
GAGCGAGACTTCGGGGTCAAGGCCCGGTCCATCCTGTGCTGCATGCGCCACCAGCCCAAC
TGGTCCCCCAAGGTGGTGGAGCTGTGTAAGAAGTACCAGCAGCAGACCGTGGTGGCCATT
GACCTGGCTGGAGATGAGACCATCCCAGGAAGCAGCCTCTTGCCTGGACATGTCCAGGCC
TACCAGGAGGCTGTGAAGAGCGGCATTCACCGTACTGTCCACGCCGGGGAGGTGGGCTCG
GCCGAAGTAGTAAAAGAGGCTGTGGACATACTCAAGACAGAGCGGCTGGGACACGGCTAC
CACACCCTGGAAGACCAGGCCCTTTATAACAGGCTGCGGCAGGAAAACATGCACTTCGAG
ATCTGCCCCTGGTCCAGCTACCTCACTGGTGCCTGGAAGCCGGACACGGAGCATGCAGTC
ATTCGGCTCAAAAATGACCAGGCTAACTACTCGCTCAACACAGATGACCCGCTCATCTTC
AAGTCCACCCTGGACACTGATTACCAGATGACCAAACGGGACATGGGCTTTACTGAAGAG
GAGTTTAAAAGGCTGAACATCAATGCGGCCAAATCTAGTTTCCTCCCAGAAGATGAAAAG
AGGGAGCTTCTCGACCTGCTCTATAAAGCCTATGGGATGCCACCTTCAGCCTCTGCAGGG
CAGAACCTCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X02994

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_3_Locus:
20q12-q13.11

# Metabolic_Enzyme_3_SNPs:
rs244076; rs11906526; rs427224; rs244078; rs2299686; rs2224999; rs379863; rs8119702; rs8119756; rs244075; rs2299691; rs2007515; rs2057637; rs762539; rs447833; rs2057638; rs6031682; rs6031690; rs6031686; rs2299688; rs6031689; rs371927; rs244079; rs2007720; rs1799880; rs2299692; rs395209; rs399159; rs2299690; rs11700291; rs929089; rs406383; rs2057639; rs967807; rs244073; rs2299694; rs452159; rs2157436; rs6031693; rs2299687; rs6017375; rs446125; rs2477898; rs6103795; rs6017378; rs445170; rs6031685; rs765215; rs6031695; rs1810751; rs2299697; rs433875; rs6031688; rs6094011; rs765216; rs244072; rs6031687; rs2299689; rs427483; rs427499; rs11907906; rs12480490; rs6103803; rs6031697; rs6017371; rs6031678; rs375379; rs384851; rs395896; rs450043; rs6094005; rs6031679; rs11698539; rs389308; rs11086932; rs6103804; rs6065738; rs1042360; rs11555566; rs7344760; rs6031698; rs394105; rs36216718; rs5841559; rs34853885; rs6017373; rs34665505; rs2765290; rs3831638; rs35553416; rs2515692; rs6031694; rs6103801; rs6103792; rs36222732; rs10561362; rs6103799; rs35009045; rs6094008; rs2007704; rs11474041; rs6103794; rs445725; rs11905649; rs6017376; rs457669; rs35383274; rs6103796; rs368253; rs6130653; rs6031691; rs11468750; rs8118045; rs6094004; rs455368; rs11484279; rs6031696; rs912912; rs6103800; rs6031684; rs445856; rs6094007; rs6017377; rs755144; rs6094009; rs11481765; rs382464; rs6103789; rs35712615; rs404898; rs6124654; rs929088; rs6031692; rs35863085; rs414146; rs6031681; rs413816; rs6103790; rs6031683; rs35436165; rs35935728; rs11698497; rs11373171; rs3091476; rs36013790; rs5841560; rs11907079; rs6103793; rs34344438; rs6017374; rs34081313; rs35535317; rs6130651; rs7353732; rs11484329; rs3041775; rs451499; rs3787359; rs11476459; rs7262528; rs6103797; rs34225524; rs11480982; rs34830340; rs6094010; rs6094006; rs3787360; rs6073497; rs11473840; rs13036408; rs34044957; rs244074; rs6103788; rs6017372; rs386512; rs35483396; rs11468701; rs2299695; rs244077; rs35505353; rs36102321; rs35545345; rs6103802; rs6103791; rs6103798; rs3831639; rs34833873; rs35784536; rs35587028; rs420183; rs6130652; rs10645831; rs36216716; rs435679; rs36216717; rs6031700; rs35153391; rs1061662; rs11699718; rs1886849; rs2071878; rs2148040; rs244081; rs244082; rs244086; rs244087; rs2664524; rs2664557; rs2664560; rs2664582; rs2664585; rs2868116; rs3180636; rs4810427; rs4810428; rs6017369; rs6031673; rs6031674; rs6031675; rs6031676; rs6031677; rs6031702; rs6031704; rs6065739; rs6094001; rs6094002; rs6094003; rs6094016; rs6094017; rs6103786; rs6103787; rs6103805; rs6103806; rs6130650; rs6130654; rs7266968; rs8118020; rs927784

# Metabolic_Enzyme_3_General_References:
6090454; 6546794; 3839456; 3028473; 11780052; 6688808; 8031011; 6208479; 3839802; 3182793; 2783588; 1284479; 8227344; 8299233; 8589684; 7599635; 9225964

# Metabolic_Enzyme_3_References:
10607474; 10611432; 10618477; 10673097

# Metabolic_Enzyme_4_ID:
5657

# Metabolic_Enzyme_4_Name:
S-adenosylmethionine decarboxylase proenzyme

# Metabolic_Enzyme_4_Synonyms:
AdoMetDC; SamDC[Contains: S-adenosylmethionine decarboxylase alpha chain; S- adenosylmethionine decarboxylase beta chain]

# Metabolic_Enzyme_4_Gene_Name:
AMD1

# Metabolic_Enzyme_4_Protein_Sequence:
>Sadenosylmethionine decarboxylase proenzyme
MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQ
EAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKP
SHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEIL
MSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYW
TIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQ
KIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS

# Metabolic_Enzyme_4_Number_of_Residues:
334

# Metabolic_Enzyme_4_Molecular_Weight:
38340

# Metabolic_Enzyme_4_Theoretical_pI:
5.78

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
Function:  adenosylmethionine decarboxylase activity
 ||
>>>
Process:  spermidine biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  polyamine metabolism
Process:  polyamine biosynthesis
Process:  spermine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
S-adenosyl-L-methionine = (5-deoxy-5- adenosyl)(3-aminopropyl)-methylsulfonium salt + CO(2)

# Metabolic_Enzyme_4_Pathway:
map00330  Arginine and proline metabolism

# Metabolic_Enzyme_4_Reaction:
S-adenosyl-L-methionine = (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01536:SAM_decarbox

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 4.1.1.50

# Metabolic_Enzyme_4_GenBank_ID_Protein:
178518

# Metabolic_Enzyme_4_SwissProt_ID:
DCAM_HUMAN (P17707)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
AMD1

# Metabolic_Enzyme_4_Geneatlas_id:
AMD1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:457

# Metabolic_Enzyme_4_PDB_ID:
1MSV

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>1005 bp
ATGGAAGCTGCACATTTTTTCGAAGGGACCGAGAAGCTGCTGGAGGTTTGGTTCTCCCGG
CAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGATCTGAGTGG
GACATACTTTTGAAGGATGTGCAATGTTCAATCATAAGTGTGACAAAAACTGACAAGCAG
GAAGCTTATGTACTCAGTGAGAGTAGCATGTTTGTCTCCAAGAGACGTTTCATTTTGAAG
ACATGTGGTACCACCCTCTTGCTGAAAGCACTGGTTCCCCTGTTGAAGCTTGCTAGGGAT
TACAGTGGGTTTGACTCAATTCAAAGCTTCTTTTATTCTCGTAAGAATTTCATGAAGCCT
TCTCACCAAGGGTACCCACACCGGAATTTCCAGGAAGAAATAGAGTTTCTTAATGCAATT
TTCCCAAATGGAGCAGGATATTGTATGGGACGTATGAATTCTGACTGTTGGTACTTATAT
ACTCTGGATTTCCCAGAGAGTCGGGTAATCAGTCAGCCAGATCAAACCTTGGAAATTCTG
ATGAGTGAGCTTGACCCAGCAGTTATGGACCAGTTCTACATGAAAGATGGTGTTACTGCA
AAGGATGTCACTCGTGAGAGTGGAATTCGTGACCTGATACCAGGTTCTGTCATTGATGCC
ACAATGTTCAATCCTTGTGGGTATTCGATGAATGGAATGAAATCGGATGGAACTTATTGG
ACTATTCACATCACTCCAGAACCAGAATTTTCTTATGTTAGCTTTGAAACAAACTTAAGT
CAGACCTCCTATGATGACCTGATCAGGAAAGTTGTAGAAGTCTTCAAGCCAGGAAAATTT
GTGACCACCTTGTTTGTTAATCAGAGTTCTAAATGTCGCACAGTGCTTGCTTCGCCCCAG
AAGATTGAAGGTTTTAAGCGTCTTGATTGCCAGAGTGCTATGTTCAATGATTACAATTTT
GTTTTTACCAGTTTTGCTAAGAAGCAGCAACAACAGCAGAGTTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M21154

# Metabolic_Enzyme_4_Chromosome_Location:
Not Available

# Metabolic_Enzyme_4_Locus:
Not Available

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
2460457; 14574404; 1917972; 10574985; 10029540; 10378277; 11583147

# Metabolic_Enzyme_4_References:
1672500; 2222506; 8331473; 8344293

# Metabolic_Enzyme_5_ID:
5235

# Metabolic_Enzyme_5_Name:
Deoxycytidine kinase

# Metabolic_Enzyme_5_Synonyms:
dCK

# Metabolic_Enzyme_5_Gene_Name:
DCK

# Metabolic_Enzyme_5_Protein_Sequence:
>Deoxycytidine kinase
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
DFKDKYESLVEKVKEFLSTL

# Metabolic_Enzyme_5_Number_of_Residues:
260

# Metabolic_Enzyme_5_Molecular_Weight:
30519

# Metabolic_Enzyme_5_Theoretical_pI:
4.88

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents

# Metabolic_Enzyme_5_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_5_Reaction:
NTP + deoxycytidine = NDP + dCMP

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01712:dNK

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.7.1.74

# Metabolic_Enzyme_5_GenBank_ID_Protein:
181510

# Metabolic_Enzyme_5_SwissProt_ID:
DCK_HUMAN (P27707)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
DCK

# Metabolic_Enzyme_5_Geneatlas_id:
DCK

# Metabolic_Enzyme_5_hgnc_id:
HGNC:2704

# Metabolic_Enzyme_5_PDB_ID:
1P62

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_5_Gene_Sequence:
>783 bp
ATGGCCACCCCGCCCAAGAGAAGCTGCCCGTCTTTCTCAGCCAGCTCTGAGGGGACCCGC
ATCAAGAAAATCTCCATCGAAGGGAACATCGCTGCAGGGAAGTCAACATTTGTGAATATC
CTTAAACAATTGTGTGAAGATTGGGAAGTGGTTCCTGAACCTGTTGCCAGATGGTGCAAT
GTTCAAAGTACTCAAGATGAATTTGAGGAACTTACAATGTCTCAGAAAAATGGTGGGAAT
GTTCTTCAGATGATGTATGAGAAACCTGAACGATGGTCTTTTACCTTCCAAACATATGCC
TGTCTCAGTCGAATAAGAGCTCAGCTTGCCTCTCTGAATGGCAAGCTCAAAGATGCAGAG
AAACCTGTATTATTTTTTGAACGATCTGTGTATAGTGACAGGTATATTTTTGCATCTAAT
TTGTATGAATCTGAATGCATGAATGAGACAGAGTGGACAATTTATCAAGACTGGCATGAC
TGGATGAATAACCAATTTGGCCAAAGCCTTGAATTGGATGGAATCATTTATCTTCAAGCC
ACTCCAGAGACATGCTTACATAGAATATATTTACGGGGAAGAAATGAAGAGCAAGGCATT
CCTCTTGAATATTTAGAGAAGCTTCATTATAAACATGAAAGCTGGCTCCTGCATAGGACA
CTGAAAACCAACTTCGATTATCTTCAAGAGGTGCCTATCTTAACACTGGATGTTAATGAA
GACTTTAAAGACAAATATGAAAGTCTGGTTGAAAAGGTCAAAGAGTTTTTGAGTACTTTG
TGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M60527

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_5_Locus:
4q13.3-q21.1

# Metabolic_Enzyme_5_SNPs:
rs4643786; rs16845677; rs1385986; rs936868; rs936869; rs1486271; rs6446999; rs4694362; rs6446988; rs10518080; rs10805074; rs7684954; rs12648166; rs4235090; rs2010401; rs7669445; rs4490428; rs7439745; rs1552381; rs16845668; rs11935198; rs4308342; rs3775289; rs7672935; rs6819369; rs12513206; rs1580469; rs7699819; rs2171195; rs7684573; rs7697366; rs13106279; rs17686997; rs11728260; rs7691350; rs7690840; rs7659473; rs9993633; rs6841923; rs9997995; rs6446989; rs11731434; rs12513202; rs6446998; rs2035576; rs2129173; rs12501375; rs11737567; rs7672339; rs16845626; rs7659998; rs1385987; rs7693891; rs7672954; rs4694360; rs4525938; rs1906021; rs11544786; rs34662212; rs5859247; rs13124044; rs13124045; rs3065775; rs35686785; rs1803484; rs13124290; rs5859246; rs28734949; rs10019874; rs4021444; rs34857131; rs34482223; rs36018698; rs11394166; rs11935525; rs35461637; rs28867977; rs12503595; rs7656043; rs35177789; rs34193080; rs13117017; rs34109101; rs35278579; rs35147498; rs11460671; rs7699712; rs28404918; rs11337561; rs34139336; rs4694363; rs3833976; rs34969740; rs34676003; rs35858453; rs35754685; rs35688113; rs36078513; rs28545112; rs9997790; rs4597793; rs35755135; rs34078875; rs4377559; rs7698012; rs2363439; rs12511143; rs11728201; rs35880082; rs11315015; rs35477149; rs28715337; rs11429170; rs7689110; rs34763060; rs2171194; rs35003502; rs34851032; rs11322673; rs7439562; rs4694361; rs35261981; rs34205711; rs2306744; rs7689093; rs28671303; rs28687395; rs12642438; rs1385985; rs3733399; rs6446977; rs6836323; rs7656269

# Metabolic_Enzyme_5_General_References:
1996353; 2013338; 9342341

# Metabolic_Enzyme_5_References:
10606241; 11562990; 15183121; 15571254

# Metabolic_Enzyme_6_ID:
6080

# Metabolic_Enzyme_6_Name:
Transketolase-like protein 1

# Metabolic_Enzyme_6_Synonyms:
Transketolase 2; TK 2; Transketolase-related protein

# Metabolic_Enzyme_6_Gene_Name:
TKTL1

# Metabolic_Enzyme_6_Protein_Sequence:
>Transketolaselike protein 1
MADAEARAEFPEEARPDRGTLQVLQDMASRLRIHSIRATCSTSSGHPTSCSSSSEIMSVL
FFYIMRYKQSDPENPDNDRFVLAKRLSFVDVATGWLGQGLGVACGMAYTGKYFDRASYRV
FCLMSDGESSEGSVWEAMAFASYYSLDNLVAIFDVNRLGHSGALPAEHCINIYQRRCEAF
GWNTYVVDGRDVEALCQVFWQASQVKHKPTAVVAKTFKGRGTPSIEDAESWHAKPMPRER
ADAIIKLIESQIQTSRNLDPQPPIEDSPEVNITDVRMTSPPDYRVGDKIATRKACGLALA
KLGYANNRVVVLDGDTRYSTFSEIFNKEYPERFIECFMAEQNMVSVALGCASRGRTIAFA
STFAAFLTRAFDHIRIGGLAESNINIIGSHCGVSVGDDGASQMALEDIAMFRTIPKCTIF
YPTDAVSTEHAVALAANAKGMCFIRTTRPETMVIYTPQERFEIGQAKVLRHCVSDKVTVI
GAGITVYEALAAADELSKQDIFIRVIDLFTIKPLDVATIVSSAKATEGRIITVEDHYPQG
GIGEAVCAAVSMDPDIQVHSLAVSGVPQSGKSEELLDMYGISARHIIVAVKCMLLN

# Metabolic_Enzyme_6_Number_of_Residues:
596

# Metabolic_Enzyme_6_Molecular_Weight:
65334

# Metabolic_Enzyme_6_Theoretical_pI:
5.65

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring aldehyde or ketonic groups
Function:  transketolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_6_Specific_Function:
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

# Metabolic_Enzyme_6_Pathway:
map00030  Pentose phosphate pathway;
 map00710  Carbon fixation;
 map01051  Biosynthesis of ansamycins

# Metabolic_Enzyme_6_Reaction:
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF02779:Transket_pyr;
PF02780:Transketolase_C;
PF00456:Transketolase_N

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.2.1.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
1232175

# Metabolic_Enzyme_6_SwissProt_ID:
TKTL1_HUMAN (P51854)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
TKTL1

# Metabolic_Enzyme_6_Geneatlas_id:
TKTL1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:11835

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic and to a lesser extent also nuclear

# Metabolic_Enzyme_6_Gene_Sequence:
>1623 bp
ATGTCTGTGCTGTTCTTCTACATCATGAGGTACAAGCAGTCAGATCCAGAGAATCCGGAC
AACGACCGATTTGTCCTCGCAAAGAGACTGTCGTTTGTGGATGTGGCAACAGGATGGCTC
GGACAAGGACTGGGAGTTGCATGTGGAATGGCATATACTGGCAAGTACTTCGACAGGGCC
AGCTACCGGGTGTTCTGCCTCATGAGTGATGGCGAGTCCTCAGAAGGCTCTGTCTGGGAG
GCAATGGCCTTTGCTTCCTACTACAGTCTGGACAATCTTGTGGCAATCTTTGATGTGAAC
CGCCTGGGACACAGTGGTGCATTGCCCGCCGAGCACTGCATAAACATCTATCAGAGGCGC
TGCGAAGCCTTTGGGTGGAACACTTATGTGGTGGACGGCCGGGACGTGGAGGCACTGTGC
CAGGTATTCTGGCAGGCTTCTCAGGTGAAGCACAAGCCCACTGCTGTGGTGGCCAAGACC
TTCAAGGGCCGGGGCACCCCAAGTATTGAGGATGCAGAAAGTTGGCATGCAAAGCCAATG
CCGAGAGAAAGAGCAGATGCCATTATCAAATTAATTGAGAGCCAGATACAGACCAGCAGG
AATCTTGACCCACAGCCCCCCATTGAGGACTCACCTGAAGTCAACATCACAGATGTAAGG
ATGACCTCTCCACCTGATTACAGAGTTGGTGACAAGATAGCTACTCGGAAAGCATGCGGT
CTGGCTCTGGCTAAGCTGGGCTACGCGAACAACAGAGTCGTTGTGCTGGATGGTGACACC
AGGTACTCTACTTTCTCTGAGATATTCAACAAGGAGTACCCTGAGCGCTTCATCGAGTGC
TTTATGGCTGAACAAAACATGGTGAGCGTGGCTCTGGGCTGTGCCTCCCGTGGACGGACC
ATTGCTTTTGCTAGCACCTTTGCTGCCTTTCTGACTCGAGCATTTGATCACATCCGGATA
GGAGGCCTCGCTGAGAGCAACATCAACATTATTGGTTCCCACTGTGGGGTATCTGTTGGT
GACGATGGTGCTTCCCAGATGGCCCTGGAGGATATAGCCATGTTCCGAACCATTCCCAAG
TGCACGATCTTCTACCCAACTGATGCCGTCTCCACGGAGCATGCTGTTGCTCTGGCAGCC
AATGCCAAGGGGATGTGCTTCATTCGGACCACCCGACCAGAAACTATGGTTATTTACACC
CCACAAGAACGCTTTGAGATCGGACAGGCCAAGGTCCTCCGCCACTGTGTCAGTGACAAG
GTCACAGTTATTGGAGCTGGAATTACTGTGTATGAAGCCTTAGCAGCTGCTGATGAGCTT
TCGAAACAAGATATTTTTATCCGTGTCATCGACCTGTTTACCATTAAACCTCTGGATGTC
GCCACCATCGTCTCCAGTGCAAAAGCCACAGAGGGCCGGATCATTACAGTGGAGGATCAC
TACCCGCAAGGTGGCATCGGGGAAGCTGTCTGCGCAGCCGTCTCCATGGATCCTGACATT
CAGGTTCATTCGCTGGCAGTGTCGGGAGTGCCCCAGAGTGGGAAGTCCGAGGAATTGCTG
GATATGTATGGAATTAGTGCCAGACATATCATAGTGGCCGTGAAATGCATGTTGCTGAAC
TAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
X91817

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_6_Locus:
Xq28

# Metabolic_Enzyme_6_SNPs:
rs17174296; rs2872817; rs12010971; rs12014497; rs17336725; rs17091217; rs766419; rs2239467; rs5987244; rs5987245; rs5987246; rs2315056; rs766420; rs5987242; rs17336718; rs2239466; rs7882247; rs5986968; rs2266894; rs2283761; rs5987237; rs2239468; rs4898475; rs12559330; rs10126322; rs12012047; rs5987241; rs4898474; rs5986969; rs6655282; rs5987239; rs12558211; rs11796895; rs6643842; rs17281251; rs12556555; rs17852259; rs34204897; rs11541774; rs12687689; rs2283759; rs12384846; rs11796894; rs35220504; rs11390439; rs12834363; rs12861292; rs11388137; rs4272554; rs5904383; rs6643844; rs34305192; rs12858825; rs7059658; rs766418; rs7054539; rs11444073; rs12832683; rs4898378; rs12848002; rs5986970; rs5987243; rs6571309; rs7878511; rs2266893; rs33991397; rs12688821; rs6655280; rs5987240; rs35018687; rs34229834; rs10602804; rs6655279; rs34910176; rs34278084; rs2283760; rs5987238; rs5945410; rs6655281; rs3056971; rs12390625; rs17091374; rs17091376; rs17091380; rs5945412; rs5945413; rs6643845; rs6655283

# Metabolic_Enzyme_6_General_References:
8838793

# Metabolic_Enzyme_6_References:
11687801; 9598103

# Metabolic_Enzyme_7_ID:
8104

# Metabolic_Enzyme_7_Name:
Deoxyguanosine kinase, mitochondrial precursor

# Metabolic_Enzyme_7_Synonyms:
dGK

# Metabolic_Enzyme_7_Gene_Name:
DGUOK

# Metabolic_Enzyme_7_Protein_Sequence:
>Deoxyguanosine kinase, mitochondrial precursor
MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK
TYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLK
VQLEPFPEKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEF
ASRITLHGFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFE
ALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL

# Metabolic_Enzyme_7_Number_of_Residues:
277

# Metabolic_Enzyme_7_Molecular_Weight:
32056

# Metabolic_Enzyme_7_Theoretical_pI:
8.97

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents

# Metabolic_Enzyme_7_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_7_Reaction:
ATP + deoxyguanosine = ADP + dGMP

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF01712:dNK

# Metabolic_Enzyme_7_Signals:
1-19

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.7.1.113

# Metabolic_Enzyme_7_GenBank_ID_Protein:
1477482

# Metabolic_Enzyme_7_SwissProt_ID:
DGUOK_HUMAN (Q16854)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
DGUOK

# Metabolic_Enzyme_7_Geneatlas_id:
DGUOK

# Metabolic_Enzyme_7_hgnc_id:
HGNC:2858

# Metabolic_Enzyme_7_PDB_ID:
1JAG

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_7_Gene_Sequence:
>834 bp
ATGGCCGCGGGCCGCCTCTTTCTAAGTCGGCTTCGAGCACCCTTCAGTTCCATGGCCAAG
AGCCCACTCGAGGGCGTTTCCTCCTCCAGAGGCCTGCACGCGGGGCGCGGGCCCCGAAGG
CTCTCCATCGAAGGCAACATTGCTGTGGGAAAGTCCACGTTTGTGAAGTTACTCACGAAA
ACTTACCCAGAATGGCACGTAGCTACAGAACCTGTAGCAACATGGCAGAATATCCAGGCT
GCTGGCAACCAAAAAGCCTGCACTGCCCAAAGTCTTGGAAACTTGCTGGATATGATGTAC
CGGGAGCCAGCACGATGGTCCTACACATTCCAGACATTTTCCTTTTTGAGCCGCCTGAAA
GTACAGCTGGAGCCCTTCCCTGAGAAACTCTTACAGGCCAGGAAGCCAGTACAGATCTTT
GAGAGGTCTGTGTACAGTGACAGGTATATCTTTGCAAAGAATCTTTTTGAAAATGGTTCC
CTCAGTGACATCGAGTGGCATATCTATCAGGACTGGCATTCTTTTCTCCTGTGGGAGTTT
GCCAGCCGGATCACATTACATGGCTTCATCTACCTCCAGGCTTCTCCCCAGGTTTGTTTG
AAGAGACTGTACCAGAGGGCCAGGGAGGAGGAGAAAGGAATTGAGCTGGCCTATCTAGAG
CAGCTGCATGGCCAACACGAAGCCTGGCTTATTCACAAGACAACGAAGCTCCACTTTGAG
GCTCTGATGAACATTCCAGTGCTGGTGTTGGATGTCAATGATGATTTTTCTGAGGAAGTA
ACCAAACAAGAAGACCTCATGAGAGAGGTAAACACCTTTGTAAAGAATCTGTAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
U41668

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_7_Locus:
2p13

# Metabolic_Enzyme_7_SNPs:
rs4777; rs10186730; rs1464690; rs831528; rs2243819; rs1464691; rs831527; rs831529; rs940299; rs2462124; rs831547; rs6737156; rs4852323; rs831550; rs940301; rs7564379; rs4852322; rs4852994; rs2002711; rs6725492; rs2694701; rs1464688; rs4077241; rs6747283; rs940298; rs2248050; rs940300; rs7557705; rs7562212; rs7558578; rs7601739; rs6546879; rs13404298; rs12470578; rs1523828; rs7606862; rs1096555; rs17009506; rs12621357; rs1464689; rs831548; rs940297; rs7565288; rs2254678; rs2243800; rs6744909; rs831549; rs2689773; rs1721260; rs6546878; rs13403888; rs11677402; rs13408733; rs831545; rs2244751; rs831524; rs11683738; rs831525; rs7568036; rs7581995; rs1721250; rs11892561; rs7567788; rs831526; rs7581999; rs7567810; rs7594405; rs7567878; rs1721251; rs7567676; rs11542976; rs1804599; rs35404246; rs10613860; rs5026865; rs35945580; rs6722482; rs35831031; rs10701633; rs13429684; rs28382406; rs4583496; rs831546; rs34850716; rs35711791; rs10573977; rs7567651; rs11306613; rs35377999; rs11884185; rs1916728; rs11357008; rs11279058; rs12329037; rs34633950; rs35726521; rs6747191; rs10585795; rs36107071; rs35979524; rs7559892; rs35066561; rs2462125; rs11342540; rs35486896; rs1726030; rs35831103; rs34963678; rs35885614; rs11327543; rs1721249; rs35616451; rs3841268; rs35826941; rs10195831; rs10196755; rs10201881; rs11126423; rs11892766; rs13387666; rs13391084; rs13397340; rs13411881; rs1622752; rs1623605; rs1653249; rs1653250; rs1653251; rs1653252; rs17009488; rs1721238; rs1726028; rs3923991; rs4530395; rs6747927; rs7570375; rs7598248; rs831522; rs831523; rs951408; rs951409

# Metabolic_Enzyme_7_General_References:
8692979; 8706825

# Metabolic_Enzyme_7_References:
16845529; 7901204; 9213430; 9463485

# Macromolecular_Interacting_Partner_1_ID:
5912

# Macromolecular_Interacting_Partner_1_Name:
Adenosine kinase

# Macromolecular_Interacting_Partner_1_Synonyms:
AK; Adenosine 5'-phosphotransferase

# Macromolecular_Interacting_Partner_1_Gene_Name:
ADK

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Adenosine kinase
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAED
KHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKA
AEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKAR
VCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGN
ETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFA
VLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPD
FH

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
362

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
40546

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.67

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleoside kinase activity
Function:  adenosine kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  purine salvage
Process:  purine ribonucleoside salvage
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides

# Macromolecular_Interacting_Partner_1_Pathway:
map00230  Purine metabolism

# Macromolecular_Interacting_Partner_1_Reaction:
ATP + adenosine = ADP + AMP

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00294:PfkB

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 2.7.1.20

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
1224125

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
ADK_HUMAN (P55263)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
ADK

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
ADK

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:257

# Macromolecular_Interacting_Partner_1_PDB_ID:
1BX4

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1038 bp
ATGACGTCAGTCAGAGAAAATATTCTCTTTGGAATGGGAAATCCTCTGCTTGACATCTCT
GCTGTAGTGGACAAAGATTTCCTTGATAAGTATTCTCTGAAACCAAATGACCAAATCTTG
GCTGAAGACAAACACAAGGAACTGTTTGATGAACTTGTGAAAAAATTCAAAGTCGAATAT
CATGCTGGTGGCTCTACCCAGAATTCAATTAAAGTGGCTCAGTGGATGATTCAACAGCCA
CACAAAGCAGCAACATTTTTTGGATGCATTGGGATAGATAAATTTGGGGAGATCCTGAAG
AGAAAAGCTGCTGAAGCCCATGTGGATGCTCATTACTACGAGCAGAATGAGCAGCCAACA
GGAACTTGTGCTGCATGCATCACTGGTGACAACAGGTCCCTCATAGCTAATCTTGCTGCT
GCCAATTGTTATAAAAAGGAAAAACATCTTGATCTGGAGAAAAACTGGATGTTGGTAGAA
AAAGCAAGAGTTTGTTATATAGCAGGCTTTTTTCTTCACGTTTCCCCAGAGTCAGTATTA
AAGGTGGCTCACCATGCTTCTGAAAACAACAGGATTTTCACTTTGAATCTATCTGCACCG
TTTATTAGCCAGTTCTACAAGGAATCATTGATGAAAGTTATGCCTTATGTTGATATACTT
TTTGGAAATGAGACAGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGAC
ATTAAAGAGATAGCCAAAAAGACACAAGCCCTGCCAAAGATGAACTCAAAGAGGCAGCGA
ATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACT
GCTTTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGAT
GCATTTGTTGGAGGTTTTCTGTCTCAACTGGTCTCTGACAAGCCTCTGACTGAATGTATC
CGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAG
AAGCCAGACTTCCACTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
U50196

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_1_Locus:
10q22|10q11-q24

# Macromolecular_Interacting_Partner_1_SNPs:
rs16931480; rs1189553; rs10824095; rs2169682; rs2894236; rs1904060; rs1904067; rs1904066; rs1871088; rs1908335; rs719624; rs1871085; rs1871087; rs2894234; rs1904064; rs871267; rs10824166; rs7350403; rs10824172; rs7090732; rs10824087; rs7894466; rs2395096; rs1898057; rs6480741; rs10740440; rs6480745; rs7098277; rs10509348; rs7079515; rs7909197; rs7899674; rs6480721; rs11597563; rs10740439; rs4451661; rs1898055; rs7079633; rs2126768; rs4390292; rs10824163; rs6480734; rs7083427; rs2169683; rs2395092; rs7072264; rs7092245; rs7922519; rs4746191; rs10824183; rs10762587; rs7100452; rs7094239; rs4564273; rs1898056; rs7096553; rs4237279; rs7087566; rs11000920; rs10762595; rs7068789; rs7100550; rs6480733; rs10762582; rs4323810; rs7098200; rs2306161; rs10824170; rs7084786; rs10824165; rs10762621; rs7923414; rs10824182; rs7916445; rs6480742; rs7082003; rs961321; rs10762624; rs10824094; rs7093532; rs7908160; rs2395095; rs6480749; rs4320897; rs10762606; rs9665468; rs10733903; rs10762601; rs11001022; rs10824133; rs10824119; rs4077282; rs10509350; rs10762640; rs4746181; rs10824195; rs7918318; rs4459229; rs6480739; rs4261231; rs10762605; rs7082872; rs3862535; rs6480727; rs7918927; rs2395087; rs10824120; rs10824186; rs7078351; rs7087368; rs7914902; rs4746214; rs1904061; rs11001105; rs10762615; rs7083534; rs10824177; rs7085940; rs10740437; rs4746182; rs10740436; rs11001043; rs2126760; rs11818050; rs6480726; rs10762612; rs7895133; rs7075643; rs7095850; rs10740443; rs4746221; rs10824185; rs4353215; rs2395097; rs2126763; rs7924176; rs7910153; rs7919277; rs7072220; rs10762636; rs10762622; rs11000931; rs4745739; rs3781255; rs10762588; rs10824138; rs10824218; rs10762638; rs2126765; rs6480731; rs4745749; rs4338470; rs7074939; rs7079709; rs4746207; rs7921187; rs11819334; rs11000960; rs11001089; rs4561146; rs11815260; rs10824193; rs10762629; rs10824135; rs7917790; rs10824105; rs11597376; rs11817779; rs7897750; rs11593868; rs4746216; rs7919166; rs11001052; rs12573619; rs10762620; rs10824197; rs7071324; rs10762596; rs11816566; rs7912162; rs7072504; rs11813905; rs10824161; rs2126767; rs10762603; rs10733895; rs7097320; rs11813953; rs7072012; rs10824122; rs7909915; rs12573590; rs4746177; rs10762639; rs726120; rs10824188; rs7913606; rs4745743; rs10740423; rs11001020; rs7075393; rs4746212; rs7923626; rs4746190; rs1556822; rs946186; rs7899920; rs10762630; rs10824134; rs12784355; rs16931294; rs2117791; rs2078036; rs12571088; rs10762607; rs10824192; rs10824137; rs11001028; rs7477710; rs10824098; rs946185; rs11814981; rs11001046; rs7916143; rs6480732; rs4745750; rs7914995; rs10509347; rs7069460; rs10740441; rs7075956; rs10762591; rs4376843; rs4281434; rs10824208; rs7901031; rs11000964; rs11818752; rs10824101; rs7099494; rs1904062; rs10762635; rs11813032; rs10824106; rs10824160; rs2126766; rs11001002; rs10762611; rs11000925; rs6480724; rs10762599; rs16931395; rs11000911; rs7917666; rs7896617; rs11816554; rs11000939; rs958620; rs12416316; rs10762641; rs10824130; rs7073742; rs12355686; rs11813815; rs2164367; rs11001109; rs9665469; rs7098337; rs10824124; rs10762619; rs10824092; rs1904065; rs12772532; rs10824174; rs7901055; rs4639878; rs1556821; rs11814426; rs6480723; rs12360119; rs10824152; rs11813920; rs10824164; rs7073340; rs10824143; rs10824103; rs4489684; rs10824210; rs12570185; rs16931536; rs1993861; rs10824151; rs12571589; rs16931460; rs11001005; rs10824144; rs7923592; rs11598232; rs10762626; rs10824128; rs10762581; rs7084139; rs1556820; rs1904058; rs10509351; rs7100084; rs11000924; rs11001018; rs12569971; rs7895587; rs2395078; rs12416497; rs10762631; rs11001053; rs11814705; rs11814063; rs10762593; rs9971034; rs16931332; rs11815536; rs11001111; rs11001007; rs4746196; rs7920097; rs16931462; rs7097778; rs12573807; rs11001099; rs11001092; rs11813221; rs7073139; rs11001034; rs12572721; rs10824102; rs1904063; rs11001004; rs10824108; rs10509349; rs10824194; rs10733904; rs10740432; rs6480740; rs3862536; rs12573198; rs7896660; rs11000922; rs10762600; rs7089391; rs12412109; rs10824096; rs10824153; rs7476181; rs11001047; rs6480729; rs10740420; rs4746192; rs7896152; rs7906603; rs7894143; rs10824221; rs2894235; rs10762608; rs7086014; rs10824129; rs11001096; rs7915999; rs7902519; rs4746188; rs11812862; rs2131955; rs2126769; rs6480722; rs11598022; rs10824146; rs10824090; rs12415957; rs11812826; rs12412071; rs4745751; rs7084204; rs7087290; rs13376718; rs10762577; rs7914783; rs10824154; rs12243059; rs7088329; rs11001029; rs11000921; rs10762586; rs1908333; rs11000928; rs7905039; rs35074621; rs12357589; rs11000948; rs10740431; rs11000997; rs11001006; rs7895292; rs11812696; rs12573068; rs11000914; rs7089625; rs7081350; rs7074449; rs11001045; rs4501938; rs7922635; rs7898073; rs7903786; rs10762637; rs12220238; rs12251845; rs12217890; rs12259556; rs6480748; rs11001115; rs16931364; rs11001059; rs10762583; rs11000899; rs11000966; rs10762613; rs4746194; rs4341485; rs6480744; rs9664463; rs12261738; rs12360399; rs12572648; rs7919517; rs11001102; rs10128407; rs10824097; rs11001085; rs12360087; rs4746180; rs6480728; rs12573347; rs11001014; rs11594742; rs11000977; rs10824107; rs10824198; rs11599616; rs10824147; rs16931492; rs10824212; rs4615968; rs12268556; rs11000996; rs4745738; rs12359456; rs16931504; rs11001003; rs956118; rs12415743; rs12261586; rs7091715; rs12356618; rs11001114; rs1871086; rs12241337; rs12569368; rs11001103; rs10740421; rs6480730; rs9299518; rs7900243; rs10824117; rs12254109; rs4746189; rs7897539; rs10762585; rs11000951; rs10824113; rs10824104; rs16931528; rs11817059; rs4745744; rs16931523; rs11597443; rs10824148; rs16931525; rs16931367; rs11000988; rs10762602; rs6480746; rs7905536; rs10762618; rs12256590; rs7069107; rs10824142; rs12098284; rs7091719; rs11819665; rs11000959; rs7091300; rs11819705; rs16931516; rs12252558; rs16931474; rs7919010; rs10824123; rs7913178; rs11000909; rs11000915; rs12243409; rs12572696; rs7920185; rs7897778; rs12569733; rs7067813; rs4746198; rs7096664; rs16931341; rs7094284; rs7903760; rs11000945; rs11001015; rs7088944; rs7897643; rs1908334; rs10824111; rs12415794; rs11001090; rs12217753; rs11591270; rs16931520; rs4745740; rs7088149; rs11000927; rs4746202; rs7076721; rs16931511; rs9651336; rs16931546; rs12779371; rs7902089; rs12569695; rs12253120; rs9664464; rs946184; rs10824116; rs10762614; rs12416580; rs4746209; rs11598266; rs4746210; rs7921832; rs16931468; rs11818734; rs10824169; rs11000992; rs7085860; rs11000936; rs11819396; rs4331029; rs10824136; rs10740442; rs1416101; rs10762594; rs11812834; rs12569856; rs12775658; rs10824171; rs7904939; rs10824140; rs7073432; rs16931449; rs12268312; rs10824110; rs11001112; rs11001078; rs7073227; rs10824099; rs12414029; rs4745747; rs7920006; rs4745745; rs12260506; rs12359289; rs12415761; rs11000990; rs11001087; rs4341483; rs11814484; rs11817882; rs11000901; rs11000980; rs11000946; rs12355188; rs7901569; rs10824112; rs10824100; rs16931465; rs10824149; rs2395091; rs10430473; rs11595136; rs11000999; rs10824109; rs10824168; rs1531; rs10430521; rs4745741; rs12242776; rs7895061; rs12773903; rs10762598; rs10824209; rs7905662; rs11815035; rs12354678; rs10824220; rs12098289; rs4746197; rs11000994; rs7099552; rs7069901; rs11000912; rs7071823; rs10824175; rs7083605; rs4746187; rs12569670; rs12356350; rs7918573; rs10824115; rs10824181; rs12570624; rs7092741; rs10824203; rs11819074; rs11001031; rs7910626; rs12415736; rs10762609; rs11001027; rs12268597; rs11001016; rs4746218; rs12570022; rs11000941; rs11000986; rs10824139; rs7086415; rs12354659; rs17747401; rs2126764; rs11599320; rs12414489; rs7080815; rs10824118; rs10824091; rs7901524; rs11812815; rs12572580; rs16931477; rs10762584; rs7904489; rs4745752; rs7906759; rs12572155; rs7084146; rs11516630; rs7901242; rs11001013; rs7074327; rs4746215; rs7898517; rs10824088; rs10824167; rs10824125; rs10824132; rs10824141; rs11599829; rs11000962; rs11594739; rs10824121; rs11813394; rs12357370; rs11000900; rs7904773; rs10824211; rs10762589; rs11000947; rs7091823; rs12252705; rs11000981; rs7087567; rs11001048; rs16931519; rs7918003; rs16931521; rs7085334; rs12265663; rs10762617; rs16931527; rs11001116; rs12411935; rs12779309; rs4746211; rs7898405; rs12242814; rs10762592; rs10762616; rs11001019; rs10430474; rs2395093; rs10824202; rs1538311; rs10824114; rs10740433; rs12573649; rs7907801; rs1529; rs11000934; rs10824150; rs10740438; rs16931538; rs11001001; rs7081573; rs11817959; rs11000987; rs7907267; rs6480743; rs7906779; rs11819130; rs16931490; rs10824190; rs2169684; rs11001008; rs11000954; rs11000916; rs7894697; rs16931472; rs1189552; rs2126762; rs1052039; rs28433006; rs12767624; rs10709030; rs7476928; rs10699958; rs35967107; rs4328165; rs12256125; rs35681751; rs6480750; rs34148029; rs35946213; rs34428151; rs36030657; rs34269690; rs3037403; rs28806480; rs34213308; rs35291653; rs12265290; rs10587775; rs11001010; rs10400100; rs5786147; rs35242280; rs34546969; rs35683991; rs10618104; rs34215048; rs35938247; rs768959; rs12769918; rs36029311; rs7909834; rs11000950; rs35036011; rs33912244; rs4746184; rs4369336; rs11000973; rs35746333; rs2027266; rs12264178; rs12768982; rs5786138; rs11427369; rs36100829; rs34310248; rs34469098; rs11470196; rs11000993; rs11310691; rs35270154; rs7392652; rs35240931; rs11001076; rs34868542; rs35677795; rs12253997; rs11001024; rs11361618; rs34483117; rs1016419; rs11001062; rs35389691; rs4746213; rs12770163; rs12242773; rs12250065; rs714446; rs7478561; rs11000983; rs35213595; rs35124446; rs12360425; rs11001041; rs7101087; rs12768640; rs34991446; rs11001107; rs34157587; rs34960972; rs11001063; rs6143984; rs11001033; rs10824216; rs7068038; rs11000963; rs12769277; rs12221297; rs34006036; rs35913987; rs35593805; rs11000958; rs35690083; rs12776428; rs12359909; rs35675013; rs34160937; rs17682987; rs11298231; rs28665887; rs34822835; rs10693309; rs12358321; rs11294383; rs35382240; rs11441752; rs11000932; rs3192342; rs10443948; rs34368934; rs16931389; rs4746219; rs7085007; rs16931551; rs12784339; rs34785655; rs35885564; rs34253447; rs34545592; rs35474264; rs35954951; rs12261116; rs1871083; rs4746220; rs12769928; rs35213605; rs34146097; rs11001025; rs1904059; rs35282438; rs34630297; rs35244559; rs36064398; rs12772349; rs35081895; rs10719538; rs12358053; rs12770150; rs10824219; rs4578321; rs11812645; rs11000944; rs11377985; rs9730888; rs11001039; rs35189522; rs11377715; rs10578956; rs12245560; rs11464387; rs11001088; rs1908336; rs2395089; rs11000918; rs7478196; rs11001093; rs35289591; rs35155141; rs10630238; rs11000935; rs11283273; rs11431842; rs11498031; rs12241229; rs12779690; rs35621346; rs35957820; rs11516631; rs35088225; rs28540400; rs35958238; rs3758511; rs11427347; rs35956325; rs11000905; rs12780859; rs34456914; rs12257326; rs11000910; rs2951091; rs11419041; rs35418682; rs35969519; rs34509827; rs34011472; rs11001073; rs13376894; rs16931407; rs11001066; rs3037448; rs34427535; rs12359976; rs11285474; rs28756681; rs34190731; rs11292901; rs34798510; rs12775686; rs7076019; rs12571515; rs35698592; rs10568623; rs7079178; rs35634749; rs35197598; rs11000998; rs34848917; rs7070345; rs35336446; rs35924345; rs34395307; rs35681211; rs34203173; rs7074078; rs11000949; rs12251148; rs11294980; rs34484828; rs7070707; rs5786139; rs35196181; rs7909032; rs34729493; rs34311007; rs35676834; rs34350496; rs35653353; rs35343842; rs35944635; rs34770422; rs35567434; rs11592151; rs34334128; rs4746208; rs12217863; rs12776780; rs10710680; rs34328974; rs11354070; rs35548449; rs35138612; rs11000937; rs5786136; rs34975658; rs11001051; rs5786148; rs12768637; rs12776762; rs11001032; rs35565783; rs35141788; rs5786145; rs34381749; rs34206298; rs16931588; rs11000972; rs34606636; rs35192408; rs11313699; rs11819453; rs12257167; rs35322063; rs34758567; rs11394734; rs4746193; rs34040400; rs12416047; rs7100239; rs35010757; rs11001050; rs35043540; rs35574014; rs35285241; rs12769920; rs11001077; rs35801937; rs9888065; rs12572719; rs12776511; rs11446202; rs11001023; rs4400738; rs34865824; rs3837336; rs12771556; rs35658711; rs11001042; rs9732237; rs34077396; rs12781732; rs12268885; rs16931430; rs34241739; rs11527234; rs11818880; rs12250504; rs12771964; rs4746185; rs11310513; rs7074915; rs35543329; rs7088493; rs34445084; rs12414124; rs10631417; rs35870828; rs35153697; rs12570068; rs2126761; rs11000976; rs12259418; rs35120068; rs34312133; rs4589228; rs34043389; rs34232307; rs11000965; rs34313197; rs12261108; rs12267421; rs35345171; rs12781539; rs1898054; rs34844657; rs12244479; rs11000933; rs12770253; rs1832436; rs35239000; rs4639879; rs35111858; rs11313781; rs12146408; rs7099493; rs36104559; rs12573253; rs12767938; rs34722640; rs35137924; rs35527525; rs35650817; rs34057132; rs34149159; rs11463660; rs11598404; rs2027265; rs41280418; rs34554027; rs12772421; rs11001068; rs11000961; rs10554301; rs11001113; rs10400099; rs35788249; rs11001074; rs11001049; rs35392498; rs11001079; rs11381604; rs34757853; rs11000984; rs10633386; rs28367539; rs35193175; rs5786149; rs36126508; rs11367583; rs34369353; rs12262949; rs35927711; rs949720; rs12769308; rs11001106; rs9733631; rs34985864; rs11527423; rs11289206; rs2894237; rs11320887; rs35035527; rs10596248; rs34829852; rs35566961; rs35148425; rs12259513; rs2395088; rs12777975; rs11001055; rs7078624; rs4746217; rs35385535; rs34440443; rs5786151; rs35822474; rs7478047; rs34684326; rs34778804; rs9731072; rs34447904; rs11458497; rs11361273; rs34029062; rs34301605; rs34969882; rs35062545; rs34668568; rs11596973; rs35067531; rs11000971; rs11000919; rs35038709; rs34848555; rs34943780; rs12775085; rs13376895; rs28550755; rs35630116; rs35480343; rs12358427; rs7476100; rs11001054; rs7916584; rs34117712; rs10646695; rs11001060; rs34025605; rs12782778; rs11000989; rs10550667; rs11001094; rs12254751; rs11001083; rs10592912; rs11001081; rs7914846; rs11001069; rs7083128; rs12771949; rs35844167; rs34807188; rs35351336; rs28798394; rs34628857; rs34464248; rs10653576; rs34498680; rs16931301; rs34644210; rs35318416; rs12357530; rs4506580; rs28886966; rs11527424; rs28711776; rs35836498; rs34575360; rs35138837; rs36106558; rs2894238; rs35333397; rs34945364; rs12261051; rs10546914; rs28705900; rs11000930; rs34022905; rs34369612; rs5786140; rs12415282; rs11001117; rs11451786; rs34788425; rs7476538; rs11000956; rs5786137; rs11000923; rs35465617; rs11001012; rs12355952; rs12267197; rs4303177; rs12254040; rs36070427; rs12770467; rs11000952; rs2027268; rs34323155; rs3037396; rs35856088; rs35278865; rs12357643; rs35046845; rs11434396; rs34777095; rs11597052; rs10667574; rs12763748; rs12414280; rs34427766; rs11498032; rs3037400; rs35287036; rs35285709; rs10710237; rs4746186; rs3037446; rs41405146; rs4746179; rs36119808; rs7072529; rs35194075; rs7094743; rs11300921; rs11000957; rs35630271; rs34844177; rs11597340; rs35918774; rs35774493; rs11599870; rs34794280; rs16931444; rs34535203; rs36041609; rs35654646; rs11357215; rs34600695; rs35167424; rs11000991; rs12764263; rs28620392; rs12765352; rs34417435; rs35499084; rs5786150; rs12771367; rs34006665; rs3957133; rs11000967; rs34878578; rs35302558; rs12255237; rs2395090; rs12098843; rs12220218; rs35091445; rs12251416; rs12764980; rs11598353; rs34605650; rs36016023; rs10693107; rs11596436; rs11000985; rs11492360; rs7100311; rs35008670; rs11001064; rs11000979; rs11001058; rs35705914; rs35798713; rs34320598; rs35102669; rs7090447; rs12261107; rs34385041; rs12267892; rs11593990; rs34053466; rs11312116; rs34287044; rs12767472; rs12359775; rs34820269; rs35056778; rs11000926; rs34396421; rs12355723; rs7083096; rs34992970; rs34064444; rs11000907; rs11001038; rs10578552; rs35152713; rs35733476; rs34480841; rs11001009; rs2395094; rs12775961; rs10558951; rs5786142; rs17744431; rs35872639; rs35658993; rs10535419; rs35203634; rs16931563; rs35781747; rs34577685; rs7082866; rs10527692; rs35945477; rs10565601; rs12248996; rs10657653; rs16931425; rs10612340; rs11000942; rs28673867; rs11001011; rs35803794; rs11000975; rs11380814; rs7093745; rs12782355; rs35927517; rs1140726; rs12262204; rs11000929; rs2027267; rs6480747; rs12247758; rs35796098; rs28457756; rs11000917; rs28599671; rs12767217; rs34601191; rs17746699; rs12098261; rs12255345; rs12250748; rs36073830; rs11297052; rs34377885; rs35708858; rs34454856; rs12241160; rs10669118; rs34336674; rs34920875; rs11001070; rs12415222; rs35421202; rs35759508; rs35249335; rs34947578; rs10400203; rs35521667; rs34161719; rs5786141; rs730660; rs11383205; rs34975150; rs2927517; rs7087005; rs11001021; rs3998213; rs12783210; rs35081179; rs10536957; rs34761801; rs11317030; rs11597174; rs35949478; rs7899397; rs12783738; rs17685047; rs11311986; rs35070470; rs28583797; rs35998695; rs11001095; rs12768800; rs34632561; rs7358249; rs34610545; rs719944; rs10559831; rs34130571; rs34419004; rs34492397; rs35960706; rs11000902; rs16931508; rs12356357; rs35369268; rs35568529; rs11000978; rs11368451; rs7909196; rs11596716; rs11591337; rs10612480; rs10710238; rs35423162; rs36067412; rs35503260; rs11001071; rs35720770; rs4746183; rs35744043; rs12250637; rs4448625; rs4746206; rs12772768; rs11377208; rs12781289; rs34033009; rs34705543; rs12770119; rs12261147; rs11510969; rs35092600; rs35989197; rs34809429; rs11001061; rs28588347; rs11356202; rs4745746; rs12221444; rs34137547; rs10534993; rs12765322; rs34589243; rs28891140; rs35036906; rs5786146; rs7101010; rs35057058; rs12763083; rs12241919; rs35010094; rs35210704; rs11001108; rs1131988; rs12776754; rs12764241; rs11285475; rs35913612; rs12773960; rs11000995; rs11279355; rs34842035; rs11592294; rs12219767; rs35370125; rs35785348; rs34133995; rs12243218; rs34631179; rs12763766; rs34123435; rs12251389; rs35116974; rs35655878; rs35281622; rs35717142; rs35955774; rs12249241; rs34740358; rs12261563; rs11492299; rs12767200; rs34775607; rs34490010; rs36042076; rs11447835; rs35273093; rs11402306; rs11814352; rs11388849; rs12241943; rs28422778; rs10689388; rs11000982; rs11597668; rs35085839; rs11278279; rs34137673; rs11001104; rs11000974; rs11001080; rs34027811; rs5786143; rs35689397; rs7898976; rs35973082; rs11001017; rs35190282; rs34346566; rs12775960; rs12769919; rs12267534; rs12251369; rs7071553; rs10698256; rs34893135; rs28612186; rs35236497; rs28842181; rs35388074; rs11000943; rs7081474; rs34535580; rs12269424; rs10682966; rs10670267; rs11000968; rs34357111; rs34359934; rs11001075; rs16931359; rs12356967; rs35233016; rs11001030; rs12255362; rs11372723; rs4638258; rs4341484; rs16931393; rs11001086; rs11000913; rs12243374; rs4745742; rs34770607; rs12778270; rs34660792; rs11000906; rs11001026; rs28473266; rs4746200; rs7089267; rs12764238; rs11001037; rs12359146; rs3837337; rs1051938; rs1051939; rs10824083; rs10824085; rs10824086; rs11000888; rs11000889; rs11000892; rs11000893; rs11000894; rs11000897; rs11817132; rs1189549; rs1189550; rs1189551; rs12256105; rs12358614; rs12572479; rs12778712; rs1338389; rs1766711; rs1766713; rs17676126; rs1774692; rs1871084; rs1874147; rs1908330; rs2788148; rs2894228; rs3812639; rs3829129; rs4638254; rs4746176; rs6480720; rs7071701; rs7079959; rs7099159; rs733350; rs7896323

# Macromolecular_Interacting_Partner_1_General_References:
8577746; 8917457; 9070863; 9843365; 12112843

# Macromolecular_Interacting_Partner_1_References:
11226375; 1435056; 15694368; 1930301

# Macromolecular_Interacting_Partner_2_ID:
8405

# Macromolecular_Interacting_Partner_2_Name:
Hypothetical protein

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Hypothetical protein
MLFKAYMYLNEGQKLLKTLKKDKSWSQTFESATFYSLKGEVCFNMGQIVLAKKMLRKALK
LLNRIFPYNLISLFLHIHVEKNRHFHYVNRQAQESPPPGKKRLAQLYRQTVCLSLLWRIY
SYSYLFHCKYYAHLAVMMQMNTALETQNCFQIIKAYLDYSLYHHLAGYKGVWFKYEVMAM
EHIFNLPLKGEGIEIVAYVAETLVFNKLIMGHLDLAIELGSRALQMWALLQNPNRHYQSL
CRLSRCLLLNSRYPQLIQVLGRLWELSVTQEHIFSKAFFYFVCLDILLYSGFVYRTFEEC
LEFIHQYENNRILKFHSGLLLGLYSSVAIWECEAGVGRRLHTSRDPGMPDFRNGTTFTNF
PIELKIFCQEEP

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
372

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
43901

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
9.26

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
EC 4.6.1.1

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
4153951

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
O95558_HUMAN (O95558)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_2_hgnc_id:
Not Available

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1119 bp
ATGCTGTTCAAGGCATACATGTATTTGAATGAAGGACAGAAGTTGCTAAAAACTCTCAAG
AAGGACAAATCTTGGAGCCAGACATTTGAGTCTGCCACCTTTTACAGCCTCAAAGGTGAG
GTCTGTTTCAATATGGGCCAGATAGTGCTTGCCAAGAAAATGCTGAGGAAGGCACTGAAG
CTCCTCAACCGAATCTTTCCTTACAACTTAATCTCCTTGTTTCTCCATATCCATGTCGAG
AAAAACAGACACTTTCATTATGTGAATCGGCAGGCCCAAGAGAGCCCACCTCCAGGGAAG
AAGAGGCTGGCACAACTTTACCGGCAAACTGTCTGCCTTTCCTTGCTGTGGCGCATCTAT
AGCTACAGTTATCTTTTTCACTGCAAGTATTATGCCCACCTGGCAGTTATGATGCAAATG
AATACTGCACTGGAAACTCAAAATTGTTTCCAGATCATTAAGGCTTACCTAGACTATTCG
CTATACCACCACCTGGCTGGCTACAAAGGTGTGTGGTTCAAATATGAAGTCATGGCCATG
GAGCACATCTTCAACCTCCCCCTGAAAGGCGAGGGCATTGAAATCGTGGCATACGTGGCT
GAGACACTGGTCTTCAACAAGCTCATAATGGGACACCTGGATTTGGCCATTGAGTTAGGC
TCCCGAGCCCTTCAGATGTGGGCACTGCTCCAGAATCCCAACCGACATTATCAGTCCCTC
TGCAGACTTAGCAGATGTCTCCTTCTGAACAGCAGATACCCGCAATTGATCCAGGTGCTG
GGGCGGCTGTGGGAGCTTTCTGTAACACAGGAACACATCTTCAGCAAGGCATTTTTCTAT
TTTGTCTGCTTGGACATCCTGCTTTATTCTGGTTTTGTTTATAGAACATTTGAAGAATGT
TTGGAATTCATACACCAATACGAAAACAACAGAATCCTCAAGTTCCACAGTGGACTCCTC
CTGGGACTTTATTCCTCTGTAGCTATCTGGGAGTGTGAAGCAGGGGTAGGCAGGAGACTA
CACACTTCCAGAGACCCAGGTATGCCAGACTTCAGGAATGGGACAACTTTTACAAATTTT
CCAATAGAGCTAAAAATCTTTTGCCAAGAAGAACCATGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AL035122

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Locus:
Not Available

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
Not Available

# Macromolecular_Interacting_Partner_2_References:
1283779; 15684499; 1719263; 7998998

End of HMDB00101

Beginning of HMDB00107
# Accession_No:
HMDB00107

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-02 11:06:40

# biospider_lastupdate:
2007-07-25 09:19:55

# Common_Name:
Galactitol

# Description:
A naturally occurring product of plants obtained following reduction of GALACTOSE. It appears as a white crystalline powder with a slight sweet taste. It may form in excess in the lens of the eye in galactosemias a deficiency of GALACTOKINASE.

# Synonyms:
Dulcose; Hexitol; Melampyrin; Melampyrit; Euonymit; Melampyrite; DAG; Melampyrum; Meso-galactitol; Dulcitol; D-dulcitol; Dulcite; Galactitol

# Chemical_IUPAC_Name:
(2S,3R,4S,5R)-hexane-1,2,3,4,5,6-hexol

# Chemical_Formula:
C6H14O6

# Chemical_Structure:
tbl_chemical:::HMDB00107_ZOOM.png:::119283191381633452

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00107_THUMB.png:::119283191187465692

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Carbohydrates

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
1,2-diol; primary alcohol; secondary alcohol

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
182.07904

# Molecular_Weight_Avg:
182.17175

# Smiles_String_isomeric:
OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO

# Smiles_String_canonical:
OCC(O)C(O)C(O)C(O)CO

# KEGG_Compound_ID:
C01697

# BioCyc_ID:
15-DIDEOXY-15-IMINO-D-GALACTITOL

# PubChem_CID:
11850

# PubChem_SID:
10355735; 10355750; 10355751; 10355754; 10529460; 10533113; 11455240; 12087644; 12437018; 132102; 155160; 16020699; 2387; 2391; 2729; 2928; 3133143; 3133751; 3178; 3682; 3884961; 4052; 419415; 4659; 4675; 476882; 4837; 4859; 5129044; 68665; 74772; 781577; 7847130; 7847164; 7988069; 7988804; 7991394; 8137783; 8137958; 8138087; 8144652; 8150647; 8158751; 86937

# OMIM_ID:
230200

# Metagene_ID:
GALACTOSEMIA: 136; GALACTOSEMIA II (GALK): 134

# BiGG_ID:
38183

# Wikipedia_ID:
Not Available

# METLIN_ID:
5148

# Ref_ID:
11092512; 6433315; 10926297; 10572890; 11174626; 7448335; 15670721; 7671965; 6434200; 2533041; 3971562; 1597290; 7214715; 7710082; 8487507

# ChEBI_ID:
16813

# CAS_Registry_Number:
608-66-2

# InChI:
InChI=1/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5+,6-

# Synthesis_Reference:
Hydrolysis of glycosides under reducing conditions.     Garegg, Per J.; Lindberg, Bengt; Konradsson, Peter; Kvarnstrom, Ingemar.    Dep. Org. Chem.,  Univ. Stockholm,  Stockholm,  Swed.    Carbohydrate Research  (1988),  176(1),  145-8.

# Melting_Point:
189.5 oC

# Melting_Point_predicted:
46.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
31 mg/mL at 15 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]; 31.0 mg/mL at 15 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
229.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-3.10 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-2.68 [Predicted by ALOGPS]; -3.9 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::1166126978.pdf:::203291698237252

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::1166127100.mol:::195495429864965

# SDF_File_[Text]:
tbl_chemical:::HMDB00107.sdf:::119283190840986546

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00107.pdb:::119283191049889702

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041012_P00_03_HW_1DP_Presat.png:::115878041078626563

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041012_P00_03_HW_1DP_Presat.zip:::115878041081090019

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041012_P00_03_HW_1DP_Assigned.png:::116111302872826348

# C_NMR_Spectra:
tbl_cnmr:::041012_P00_03_HW_1DC_80.jpg:::114168460228976132

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041012_P00_03_HW_1DC_80.zip:::114168460225357768

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041012_P00_03_HW_1DC_80_Assigned.jpg:::114322925621276448

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041012_P00_03_HW_2DHSQC_274.jpg:::11456586554628965

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041012_P00_03_HW_2DHSQC_274.zip:::114565865547048630

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041012_P00_03_HW_2DHSQC_274_Assigned.jpg:::114565865560998479

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Galactitol.gif:::1132732108984811432

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00107_peaks.txt:::1156309548262295131

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Galactitol_C.gif:::1132737684556266173

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00107_peaks.txt:::1156310738433622977

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00107.png:::1165435226503464711; Medium Energy:tbl_ms:::HMDB00107.png:::1165434661018423146; High Energy:tbl_ms:::HMDB00107.png:::1165434853060304645

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP)

# Tissue_Location:
Brain; Erythrocyte; Eye Lens; Lens

# deuterated:
No

# Biofluid_Location:
Amniotic Fluid; Blood; CSF; Urine

# Concentration_[Normal]:
Urine	42 (3-81)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	7671965
Blood	0.56 +/- 0.41	uM	Adult:>18_yrs_old	Both	Normal	6434200
Blood	1.48 +/- 0.32	umol/L	Adult:>18_yrs_old	Both	Normal	11092512
Blood	0.36 (0.23-0.48)	umol/L	Adult:>18_yrs_old	Both	Normal	7710082
Cerebrospinal_Fluid(CSF)	1.65 +/- 0.44 	uM	Adult:>18_yrs_old	Both	Normal	8595727
Cerebrospinal_Fluid(CSF)	1.82 (1.17-2.47)	umol/L	Adult:>18_yrs_old	Both	Normal	7710082
Amniotic_Fluid	0.7 +/- 0.18	umol/L	N/A	Both	Normal	6433315


# Concentration_[Abnormal]:
Urine	38500 (8000 - 69000)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Galactosemia	7671965
Urine	472.5 (45-900)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Galactosemia	7671965
Cerebrospinal_Fluid(CSF)	1.65 +/- 0.22 	N/A	Adult:>18_yrs_old	Both	Alzheimer	8595727
Amniotic_Fluid	7.96	umol/L	Adult:>18_yrs_old	Both	Galactosemia	6433315


# Associated_Disorders:
Alzheimer; Cataract; Galactokinase Deficiency; Galactose-1-Phosphate Uridyltransferase (GALT) Deficiency; Galactosemia; Galt Deficiency

# Pathway_Names:
Not Available

# Pathway_Images:
Not Available

# KEGG_Images:
Not Available

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
6675

# Metabolic_Enzyme_1_Name:
Galactokinase

# Metabolic_Enzyme_1_Synonyms:
Galactose kinase

# Metabolic_Enzyme_1_Gene_Name:
GALK1

# Metabolic_Enzyme_1_Protein_Sequence:
>Galactokinase
MAALRQPQVAELLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELM
TVLVGSPRKDGLVSLLTTSEGADEPQRLQFPLPTAQRSLEPGTPRWANYVKGVIQYYPAA
PLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLCPDSGTIAARAQVCQQAEHSFAGM
PCGIMDQFISLMGQKGHALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLASSEYPVRR
RQCEEVARALGKESLREVQLEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDY
RAFGRLMVESHRSLRDDYEVSCPELDQLVEAALAVPGVYGSRMTGGGFGGCTVTLLEASA
APHAMRHIQEHYGGTATFYLSQAADGAKVLCL

# Metabolic_Enzyme_1_Number_of_Residues:
392

# Metabolic_Enzyme_1_Molecular_Weight:
42273

# Metabolic_Enzyme_1_Theoretical_pI:
6.42

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  galactokinase activity
 ||
>>>
Process:  phosphorus metabolism
Process:  phosphate metabolism
Process:  phosphorylation
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  carbohydrate phosphorylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  galactose metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Major enzyme for galactose metabolism

# Metabolic_Enzyme_1_Pathway:
map00052  Galactose metabolism

# Metabolic_Enzyme_1_Reaction:
ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF08544:GHMP_kinases_C;
PF00288:GHMP_kinases_N

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.7.1.6

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1002507

# Metabolic_Enzyme_1_SwissProt_ID:
GALK1_HUMAN (P51570)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
GALK1

# Metabolic_Enzyme_1_Geneatlas_id:
GALK1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4118

# Metabolic_Enzyme_1_PDB_ID:
1WUU

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1179 bp
ATGGCTGCTTTGAGACAGCCCCAGGTCGCGGAGCTGCTGGCCGAGGCCCGGCGAGCCTTC
CGGGAGGAGTTCGGGGCCGAGCCCGAGCTGGCCGTGTCAGCGCCGGGCCGCGTCAACCTC
ATCGGGGAACACACGGACTACAACCAGGGCCTGGTGCTGCCTATGGCTCTGGAGCTCATG
ACGGTGCTGGTGGGCAGCCCCCGCAAGGATGGGCTGGTGTCTCTCCTCACCACCTCTGAG
GGTGCCGATGAGCCCCAGCGGCTGCAGTTTCCACTGCCCACAGCCCAGCGCTCGCTGGAG
CCTGGGACTCCTCGGTGGGCCAACTATGTCAAGGGAGTGATTCAGTACTACCCAGCTGCC
CCCCTCCCTGGCTTCAGTGCAGTGGTGGTCAGCTCAGTGCCCCTGGGGGGTGGCCTGTCC
AGCTCAGCATCCTTGGAAGTGGCCACGTACACCTTCCTCCAGCAGCTCTGTCCAGACTCG
GGCACAATAGCTGCCCGCGCCCAGGTGTGTCAGCAGGCCGAGCACAGCTTCGCAGGGATG
CCCTGTGGCATCATGGACCAGTTCATCTCACTTATGGGACAGAAAGGCCACGCGCTGCTC
ATTGACTGCAGGTCCTTGGAGACCAGCCTGGTGCCACTCTCGGACCCCAAGCTGGCCGTG
CTCATCACCAACTCTAATGTCCGCCACTCCCTGGCCTCCAGCGAGTACCCTGTGCGGCGG
CGCCAATGTGAAGAAGTGGCCCGGGCGCTGGGCAAGGAAAGCCTCCGGGAGGTACAACTG
GAAGAGCTAGAGGCTGCCAGGGACCTGGTGAGCAAAGAGGGCTTCCGGCGGGCCCGGCAC
GTGGTGGGGGAGATTCGGCGCACGGCCCAGGCAGCGGCCGCCCTGAGACGTGGCGACTAC
AGAGCCTTTGGCCGCCTCATGGTGGAGAGCCACCGCTCACTCAGAGACGACTATGAGGTG
AGCTGCCCAGAGCTGGACCAGCTGGTGGAGGCTGCGCTTGCTGTGCCTGGGGTTTATGGC
AGCCGCATGACGGGCGGTGGCTTCGGTGGCTGCACGGTGACACTGCTGGAGGCCTCCGCT
GCTCCCCACGCCATGCGGCACATCCAGGAGCACTACGGCGGGACTGCCACCTTCTACCTC
TCTCAAGCAGCCGATGGAGCCAAGGTGCTGTGCTTGTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U26401

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_1_Locus:
17q24

# Metabolic_Enzyme_1_SNPs:
rs7211385; rs820385; rs2444842; rs7209235; rs820384; rs820386; rs4788909; rs8073866; rs8078433; rs1979215; rs34947616; rs4633773; rs34122576; rs34653297; rs12601977; rs10624000; rs8072914; rs8074561; rs35053784; rs35008831; rs12602523; rs10670567; rs34651064; rs34797502; rs35352665; rs35989708; rs34208166; rs2603511; rs12940075; rs4392122; rs7212710; rs9912453; rs1008177; rs1008179; rs1051486; rs1051554; rs11465; rs11649838; rs13623; rs2603498; rs2603499; rs2603500; rs2603501; rs2603502; rs2603503; rs2603507; rs2603508; rs2603510; rs3191773; rs34536514; rs7223563; rs743554; rs8078247; rs820387; rs820388; rs820391; rs8669; rs871443; rs9367

# Metabolic_Enzyme_1_General_References:
7670469; 8908517; 7542884; 10521295; 11231902

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5320

# Metabolic_Enzyme_2_Name:
Aldose reductase

# Metabolic_Enzyme_2_Synonyms:
AR; Aldehyde reductase

# Metabolic_Enzyme_2_Gene_Name:
AKR1B1

# Metabolic_Enzyme_2_Protein_Sequence:
>Aldose reductase
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF

# Metabolic_Enzyme_2_Number_of_Residues:
316

# Metabolic_Enzyme_2_Molecular_Weight:
35854

# Metabolic_Enzyme_2_Theoretical_pI:
6.99

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies

# Metabolic_Enzyme_2_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism

# Metabolic_Enzyme_2_Reaction:
alditol + NAD(P)+ = aldose + NAD(P)H + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.1.21

# Metabolic_Enzyme_2_GenBank_ID_Protein:
178487

# Metabolic_Enzyme_2_SwissProt_ID:
ALDR_HUMAN (P15121)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
AKR1B1

# Metabolic_Enzyme_2_Geneatlas_id:
AKR1B1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:381

# Metabolic_Enzyme_2_PDB_ID:
1T40

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>951 bp
ATGGCAAGCCGTCTCCTGCTCAACAACGGCGCCAAGATGCCCATCCTGGGGTTGGGTACC
TGGAAGTCCCCTCCAGGGCAGGTGACTGAGGCCGTGAAGGTGGCCATTGACGTCGGGTAC
CGCCACATCGACTGTGCCCATGTGTACCAGAATGAGAATGAGGTGGGGGTGGCCATTCAG
GAGAAGCTCAGGGAGCAGGTGGTGAAGCGTGAGGAGCTCTTCATCGTCAGCAAGCTGTGG
TGCACGTACCATGAGAAGGGCCTGGTGAAAGGAGCCTGCCAGAAGACACTCAGCGACCTG
AAGCTGGACTACCTGGACCTCTACCTTATTCACTGGCCGACTGGCTTTAAGCCTGGGAAG
GAATTTTTCCCATTGGATGAGTCGGGCAATGTGGTTCCCAGTGACACCAACATTCTGGAC
ACGTGGGCGGCCATGGAAGAGCTGGTGGATGAAGGGCTGGTGAAAGCTATTGGCATCTCC
AACTTCAACCATCTCCAGGTGGAGATGATCTTAAACAAACCTGGCTTGAAGTATAAGCCT
GCAGTTAACCAGATTGAGTGCCACCCATATCTCACTCAGGAGAAGTTAATCCAGTACTGC
CAGTCCAAAGGCATCGTGGTGACCGCCTACAGCCCCCTCGGCTCTCCTGACAGGCCCTGG
GCCAAGCCCGAGGACCCTTCTCTCCTGGAGGATCCCAGGATCAAGGCGATCGCAGCCAAG
CACAATAAAACTACAGCCCAGGTCCTGATCCGGTTCCCCATGCAGAGGAACTTGGTGGTG
ATCCCCAAGTCTGTGACACCAGAACGCATTGCTGAGAACTTTAAGGTCTTTGACTTTGAA
CTGAGCAGCCAGGATATGACCACCTTACTCAGCTACAACAGGAACTGGAGGGTCTGTGCC
TTGTTGAGCTGTACCTCCCACAAGGATTACCCCTTCCATGAAGAGTTTTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
J04795

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_2_Locus:
7q35

# Metabolic_Enzyme_2_SNPs:
rs5054; rs5060; rs5059; rs2229543; rs3087630; rs5055; rs5053; rs1790999; rs1790998; rs1646640; rs4732027; rs2734653; rs3896278; rs2734650; rs10954455; rs1708432; rs10808275; rs17660462; rs2670227; rs11974100; rs2734657; rs2670232; rs1424426; rs2734649; rs2551472; rs2259458; rs17188118; rs12669537; rs2734655; rs7778371; rs1708434; rs11971263; rs2670230; rs10273906; rs17167854; rs2734665; rs969309; rs2701020; rs2734663; rs2734664; rs706207; rs759853; rs17167851; rs918825; rs918824; rs11975656; rs17856148; rs11544687; rs5057; rs4728325; rs5061; rs5062; rs5056; rs17849987; rs1803093; rs3210035; rs11544690; rs13306160; rs1803094; rs1803095; rs2852171; rs2854854; rs2551469; rs3749434; rs2734661; rs2670231; rs2551471; rs1791000; rs2670240; rs2734659; rs2852165; rs2551476; rs3216672; rs2854849; rs7801237; rs2269068; rs10588800; rs35880193; rs2734658; rs34559471; rs2691837; rs1732035; rs2852170; rs2854853; rs2670239; rs1646639; rs2854851; rs5058; rs2551470; rs2670233; rs13306159; rs2854848; rs2701019; rs2734660; rs1732037; rs2852164; rs11417418; rs35431624; rs2852163; rs2269069; rs35632302; rs2852173; rs2854850; rs2551473; rs35338055; rs2691840; rs2852172; rs2734652; rs2852167; rs2854852; rs6963238; rs1791006; rs34569487; rs2670229; rs2551475; rs2691838; rs13306161; rs3216673; rs2974975; rs2551474; rs34678793; rs2551467; rs33945153; rs2852169; rs2734656; rs2854846; rs2734651; rs2691839; rs2734662; rs2852166; rs2691841; rs2551468; rs2691835; rs2551477; rs2691836; rs13306162; rs1708427; rs2852168; rs2670226; rs1621922; rs2852174; rs2551465; rs2691845; rs2551466; rs918826; rs35706999; rs2852176; rs2691846; rs1708404; rs12532832; rs1732039; rs1646636; rs1646642; rs1646637; rs2852175; rs1646641; rs10228986; rs10236262; rs10236468; rs10241645; rs10244489; rs10252030; rs10263438; rs10275865; rs11973239; rs13225343; rs1708414; rs1708415; rs1708416; rs17167841; rs1722900; rs1722911; rs1732038; rs1791001; rs2347375; rs2670228; rs6977866; rs706206; rs7802421; rs782054

# Metabolic_Enzyme_2_General_References:
2498333; 2504709; 2510130; 2111143; 2112546; 1901857; 9195951; 8435445; 2492527; 8343525; 8281941; 8245005; 1621098; 1447221; 8234324; 9405046

# Metabolic_Enzyme_2_References:
7980654; 8580001; 9088040

End of HMDB00107

Beginning of HMDB00108
# Accession_No:
HMDB00108

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-23 12:09:23

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Ethanol

# Description:
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.

# Synonyms:
1-Hydroxyethane; Absolute alcohol; Absolute ethanol; Absolute ethyl alcohol; Aethanol; Aethylalkohol; Alcare Hand Degermer; Alcohol; Alcohols; Alcool ethylique; Alcool etilico; Algrain; Alkohol; Alkoholu etylowego; Anhydrol; Anhydrous alcohol; Cologne spirit; Cologne spirits; Dehydrated alcohol; Dehydrated ethanol; Denatured alcohol; Denatured ethanol; Desinfektol EL; Distilled spirits; Ethanol 200 proof; Ethanol solution; Ethicap; Ethyl alc; Ethyl alcohol; Ethyl alcohol anhydrous; Ethyl alcohol in alcoholic beverages; Ethyl alcohol usp; Ethyl hydrate; Ethyl hydroxide; Fermentation alcohol; Grain alcohol; Hinetoless; Hydroxyethane; Infinity Pure; Jaysol; Jaysol S; Lux; Methylcarbinol; Molasses alcohol; Potato alcohol; Punctilious ethyl alcohol; Pyro; Spirit; Spirits of wine; Spirt; Synasol; Tecsol; Tecsol C; Thanol; diluted Alcohol; silent spirit; undenatured Ethanol

# Chemical_IUPAC_Name:
ethanol

# Chemical_Formula:
C2H6O

# Chemical_Structure:
tbl_chemical:::HMDB00108_ZOOM.png:::119283192190746292

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00108_THUMB.png:::119283192052982437

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Alcohols

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary alcohol

# Taxonomy_Biofunction:
Component of Androgen and estrogen metabolism; Component of Bile acid biosynthesis; Component of C21-Steroid hormone metabolism; Component of Fatty acid metabolism; Component of Glycerolipid metabolism; Component of Sulfur metabolism; Component of Tyrosine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
46.04187

# Molecular_Weight_Avg:
46.06844

# Smiles_String_isomeric:
CCO

# Smiles_String_canonical:
CCO

# KEGG_Compound_ID:
C00469

# BioCyc_ID:
ETOH

# PubChem_CID:
702

# PubChem_SID:
2694; 818768; 7979196; 7847136; 841053; 836080; 8145680; 818786; 122577; 836986; 10324365; 7344411; 834309; 12578012; 825155; 7887325; 693762; 7889631; 10531509; 3137603; 827842; 835535; 3752; 588484; 601786; 7887328; 818776; 7889563; 7852076; 8150751; 693661; 687596; 149046; 14709184; 830328

# OMIM_ID:
Not Available

# Metagene_ID:
HYPOPHOSPHATASIA: 440; ETHANOLAMINOSIS: 132

# BiGG_ID:
35062

# Wikipedia_ID:
Ethanol

# METLIN_ID:
3203

# Ref_ID:
12097436; 12639646; 10657263; 7049929; 10833489; 573652; 8801213; 14639920; 15386367; 16539214; 6123447; 7473189; 6282953; 16266372; 9703331; 16685217; 12699475; 7738189; 16686720; 16739925

# ChEBI_ID:
16236

# CAS_Registry_Number:
64-17-5

# InChI:
InChI=1/C2H6O/c1-2-3/h3H,2H2,1H3

# Synthesis_Reference:
he kinetics of reactions in solution. The interaction of potassium hydroxide and the alkyl halides in ethyl alcohol.     Grant, G. H.; Hinshelwood, C. N.    Journal of the Chemical Society  (1933),     258-61.

# Melting_Point:
-114.1 oC

# Melting_Point_predicted:
16.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1000.0 mg/mL [RIDDICK,JA et al. (1986)]

# H2O_Solubility_Predicted:
579.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Liquid

# LogP:
-0.31 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-0.40 [Predicted by ALOGPS]; -0.1 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Ethanol-d1.pdf:::1132562200760662939

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Ethanol.mol:::1132723807609884624

# SDF_File_[Text]:
tbl_chemical:::HMDB00108.sdf:::119283191779271293

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00108.pdb:::119283191916340124

# PDB_ID:
1A7S

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1A7S.txt:::1132720901671907471

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041104_P00_03_HW_1DP_presat.png:::114866234051936304

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041104_P00_03_HW_1DP_presat.zip:::114866234057182189

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041104_P00_03_HW_1DP_Assigned.png:::115644185631027198

# C_NMR_Spectra:
tbl_cnmr:::041104_P00_03_HW_1DC_91.jpg:::114244924378263734

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041104_P00_03_HW_1DC_91.zip:::114244924382527134

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041104_P00_03_HW_1DC_91_Assigned.jpg:::114322927499855991

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041104_P00_03_HW_2DHSQC_314.jpg:::114565797478559024

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041104_P00_03_HW_2DHSQC_314.zip:::114565797510972510

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041104_P00_03_HW_2DHSQC_314_Assigned.jpg:::114565797526414290

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Ethanol.gif:::1132732109187868653

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00108_peaks.txt:::1156309549294383252

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Ethanol_C.gif:::1132737685157896987

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00108_peaks.txt:::1156310739490599576

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000297.png:::116907445790622244

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000297.txt:::11690744579067428

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000297.png:::116890834812532111

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000297.txt:::11689083483286251

# Cellular_Location:
Cytoplasm; Extracellular; peroxisome

# Tissue_Location:
Adipose Tissue; Adrenal Cortex; Adrenal Gland; Adrenal Medulla; Bladder; Brain; Epidermis; Fetus; Fibroblasts; Gonads; Gut; Heart; Intestine; Kidney; Liver; Lung; Mouth; Muscle; Myelin; Nerves; Neurons; Pancreas; Placenta; Platelet; Prostate; Skeletal Mus

# deuterated:
No

# Biofluid_Location:
Blood; Saliva; Urine

# Concentration_[Normal]:
Urine	<0.01	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	10833489
Blood	0.0-80.0	umol/L	Adult:>18_yrs_old	Both	Normal	7049929 
Blood	0.0-33.0	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Saliva	>10	umol/L	Adult:>18_yrs_old	Both	Normal	12097436


# Concentration_[Abnormal]:
Urine	54.0 (0.0-661.0)	umol/mmol_creatinine	N/A	Both	Lung Cancer	HMP experimental


# Associated_Disorders:
Cachexia; Ethanolaminosis; Hypophosphatasia; Lung Cancer; Pancreatitis

# Pathway_Names:
Not Available

# Pathway_Images:
Not Available

# KEGG_Images:
Not Available

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5527

# Metabolic_Enzyme_1_Name:
Aldehyde dehydrogenase, dimeric NADP-preferring

# Metabolic_Enzyme_1_Synonyms:
ALDH class 3; ALDHIII

# Metabolic_Enzyme_1_Gene_Name:
ALDH3A1

# Metabolic_Enzyme_1_Protein_Sequence:
>Aldehyde dehydrogenase, dimeric NADPpreferring
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH

# Metabolic_Enzyme_1_Number_of_Residues:
453

# Metabolic_Enzyme_1_Molecular_Weight:
50380

# Metabolic_Enzyme_1_Theoretical_pI:
6.52

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes

# Metabolic_Enzyme_1_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_1_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
178402

# Metabolic_Enzyme_1_SwissProt_ID:
AL3A1_HUMAN (P30838)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ALDH3A1

# Metabolic_Enzyme_1_Geneatlas_id:
ALDH3A1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:405

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1362 bp
ATGAGCAAGATCAGCGAGGCCGTGAAGCGCGCCCGCGCCGCCTTCAGCTCGGGCAGGACC
CGTCCGCTGCAGTTCCGATTCCAGCAGCTGGAGGCGCTGCAGCGCCTGATCCAGGAGCAG
GAGCAGGAGCTGGTGGGCGCGCTGGCCGCAGACCTGCACAAGAATGAATGGAACGCCTAC
TATGAGGAGGTGGTGTACGTCCTAGAGGAGATCGAGTACATGATCCAGAAGCTCCCTGAG
TGGGCCGCGGATGAGCCCGTGGAGAAGACGCCCCAGACTCAGCAGGACGAGCTCTACATC
CACTCGGAGCCACTGGGCGTGGTCCTCGTCATTGGCACCTGGAACTACCCCTTCAACCTC
ACCATCCAGCCCATGGTGGGCGCCATCGCTGCAGGGAACGCAGTGGTCCTCAAGCCCTCG
GAGCTGAGTGAGAACATGGCGAGCCTGCTGGCTACCATCATCCCCCAGTACCTGGACAAG
GATCTGTACCCAGTAATCAATGGGGGTGTCCCTGAGACCACGGAGCTGCTCAAGGAGAGG
TTCGACCATATCCTGTACACGGGCAGCACGGGGGTGGGGAAGATCATCATGACGGCTGCT
GCCAAGCACCTGACCCCTGTCACGCTGGAGCTGGGAGGGAAGAGTCCCTGCTACGTGGAC
AAGAACTGTGACCTGGACGTGGCCTGCCGACGCATCGCCTGGGGGAAATTCATGAACAGT
GGCCAGACCTGCGTGGCCCCAGACTACATCCTCTGTGACCCCTCGATCCAGAACCAAATT
GTGGAGAAGCTCAAGAAGTCACTGAAAGAGTTCTACGGGGAAGATGCTAAGAAATCCCGG
GACTATGGAAGAATCATTAGTGCCCGGCACTTCCAGAGGGTGATGGGCCTGATTGAGGGC
CAGAAGGTGGCTTATGGGGGCACCGGGGATGCCGCCACTCGCTACATAGCCCCCACCATC
CTCACGGACGTGGACCCCCAGTCCCCGGTGATGCAAGAGGAGATCTTCGGGCCTGTGCTG
CCCATCGTGTGCGTGCGCAGCCTGGAGGAGGCCATCCAGTTCATCAACCAGCGTGAGAAG
CCCCTGGCCCTCTACATGTTCTCCAGCAACGACAAGGTGATTAAGAAGATGATTGCAGAG
ACATCCAGTGGTGGGGTGGCGGCCAACGATGTCATCGTCCACATCACCTTGCACTCTCTG
CCCTTCGGGGGCGTGGGGAACAGCGGCATGGGATCCTACCATGGCAAGAAGAGCTTCGAG
ACTTTCTCTCACCGCCGCTCTTGCCTGGTGAGGCCTCTGATGAATGATGAAGGCCTGAAG
GTCAGATACCCCCCGAGCCCGGCCAAGATGACCCAGCACTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M74542

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_1_Locus:
17p11.2

# Metabolic_Enzyme_1_SNPs:
rs887241; rs2228100; rs3744692; rs2072330; rs4646787; rs1042183; rs917520; rs4646789; rs4646788; rs3786036; rs887240; rs2072329; rs4646790; rs3744693; rs9895030; rs3826507; rs3744695; rs3744694; rs2072328; rs1006556; rs4319825; rs1042172; rs11554977; rs11554978; rs11554975; rs11554974; rs34474118; rs3786037; rs35473971; rs4646792; rs35116940; rs4646791; rs35853488; rs887239; rs28531080; rs7216299; rs35009373; rs3786035; rs11385990; rs35308039; rs35128135; rs35885485; rs28552545; rs34438543; rs1006553; rs11650088; rs11651480; rs11870332; rs12948881; rs12949049; rs12951039; rs16960382; rs16960386; rs17793620; rs1989379; rs2016823; rs2052052; rs2072327; rs2108967; rs3760485; rs3760486; rs3760487; rs4646783; rs4646784; rs4646785; rs4646786; rs4924793; rs4925046; rs7214841; rs7221211; rs7225305; rs8075157; rs9898715; rs9900430

# Metabolic_Enzyme_1_General_References:
1737758; 8493892; 2037078; 9250352

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6062

# Metabolic_Enzyme_2_Name:
Alcohol dehydrogenase 1B

# Metabolic_Enzyme_2_Synonyms:
Alcohol dehydrogenase beta subunit

# Metabolic_Enzyme_2_Gene_Name:
ADH1B

# Metabolic_Enzyme_2_Protein_Sequence:
>Alcohol dehydrogenase 1B
MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVT
PLPVILGHEA
AGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGN
PRGTLQDGTRRFTCRGKPIHH
FLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFS
TGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVM
GCKAAGAARIIAVDINKDKFAKAKELG
ATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASL
LCCHEACGTSVIVGVP
PASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHV
LPFEK
INEGFDLLHSGKSIRTVLTF

# Metabolic_Enzyme_2_Number_of_Residues:
375

# Metabolic_Enzyme_2_Molecular_Weight:
39855

# Metabolic_Enzyme_2_Theoretical_pI:
8.38

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
An alcohol + NAD(+) = an aldehyde or ketone + NADH

# Metabolic_Enzyme_2_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_2_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
178098

# Metabolic_Enzyme_2_SwissProt_ID:
ADH1B_HUMAN (P00325)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ADH1B

# Metabolic_Enzyme_2_Geneatlas_id:
ADH1B

# Metabolic_Enzyme_2_hgnc_id:
HGNC:250

# Metabolic_Enzyme_2_PDB_ID:
1HSZ

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1128 bp

ATGAGCACAGCAGGAAAAGTAATCAAATGCAAAGCAGCTGTGCTATGGGAGGTAAAGAA
ACCCTTTTCCA
TTGAGGATGTGGAGGTTGCACCTCCTAAGGCTTATGAAGTTCGCATTA
AGATGGTGGCTGTAGGAATCTG
TCGCACAGATGACCACGTGGTTAGTGGCAACCTGGTG
ACCCCCCTTCCTGTGATTTTAGGCCATGAGGCA
GCCGGCATCGTGGAGAGTGTTGGAGA
AGGGGTGACTACAGTCAAACCAGGTGATAAAGTCATCCCGCTCT
TTACTCCTCAGTGTG
GAAAATGCAGAGTTTGTAAAAACCCGGAGAGCAACTACTGCTTGAAAAATGATCT
AGGC
AATCCTCGGGGGACCCTGCAGGATGGCACCAGGAGGTTCACCTGCAGGGGGAAGCCCATT
CACCAC
TTCCTTGGCACCAGCACCTTCTCCCAGTACACGGTGGTGGATGAGAATGCAGT
GGCCAAAATTGATGCAG
CCTCGCCCCTGGAGAAAGTCTGCCTCATTGGCTGTGGATTCT
CGACTGGTTATGGGTCTGCAGTTAACGT
TGCCAAGGTCACCCCAGGCTCTACCTGTGCT
GTGTTTGGCCTGGGAGGGGTCGGCCTATCTGCTGTTATG
GGCTGTAAAGCAGCTGGAGC
AGCCAGAATCATTGCGGTGGACATCAACAAGGACAAAAAAGCAAAGGCCA
AAGAGTTGG
GTGCCACTGAATGCATCAACCCTCAAGACTACAAGAAACCCATCCAGGAAGTGCTAAAGG
A
AATGACTGATGGAGGTGTGGATTTTTCGTTTGAAGTCATCGGTCGGCTTGACACCATG
ATGGCTTCCCTG
TTATGTTGTCATGAGGCATGTGGCACAAGCGTCATCGTAGGGGTACC
TCCTGCTTCCCAGAACCTCTCAA
TAAACCCTATGCTGCTACTGACTGGACGCACCTGGA
AGGGGGCTGTTTATGGTGGCTTTAAGAGTAAAGA
AGGTATCCCAAAACTTGTGGCTGAT
TTTATGGCTAAGAAGTTTTCACTGGATGCGTTAATAACCCATGTT
TTACCTTTTGAAAA
AATAAATGAAGGATTTGACCTGCTTCACTCTGGGAAAAGTATCCGTACCGTCCTGA
CGT
TTTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M24317

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_2_Locus:
4q21-q23

# Metabolic_Enzyme_2_SNPs:
rs6413413; rs2066702; rs1229984; rs1041969; rs28626993; rs1789882; rs2018417; rs1229983; rs1042026; rs17033; rs28914789; rs3840296; rs28914788; rs1353621; rs12498658; rs1693457; rs17028834; rs6850217; rs10005290; rs2066701; rs9282578; rs11730075; rs2075633; rs9282577; rs4147536; rs28913906; rs28914783; rs1235416; rs28914772; rs13133908; rs28914770; rs28914773; rs1229985; rs28914769; rs28913922; rs1789880; rs1229986; rs28913915; rs1789883; rs28914768; rs28914775; rs4147539; rs28914785; rs7673353; rs28914784; rs28913924; rs28913907; rs2018613; rs28913921; rs1159918; rs12507573; rs3811801; rs3811802; rs1229982; rs1693458; rs1229981; rs2070898; rs28913902; rs2070897; rs28914792; rs28913901; rs28914793; rs1789878; rs3133155; rs28914794; rs28913903; rs1126441; rs41275699; rs1126440; rs41275697; rs28914790; rs35274586; rs3211503; rs34503441; rs35273731; rs28913919; rs28914777; rs28913926; rs28914782; rs34044126; rs28913909; rs17028839; rs7441278; rs28913916; rs34689791; rs28913918; rs28914786; rs35046750; rs28914781; rs35105761; rs28914776; rs28913911; rs10711677; rs4147538; rs28914780; rs7435646; rs34702119; rs28913923; rs28914779; rs4147535; rs28913913; rs28913920; rs28913908; rs28913914; rs28913910; rs28913917; rs28913925; rs35822752; rs28914778; rs28913912; rs28914787; rs10033960; rs34198524; rs28914774; rs3840297; rs28914791; rs13114844; rs5860575; rs1789877; rs34004679; rs36208360; rs34739423; rs6839995; rs36038206; rs28913904; rs28913905; rs34644331; rs1789879; rs35468479; rs1229863; rs1229864; rs13103321; rs13117371; rs13145277; rs1693439; rs1789888; rs1789890; rs1789891; rs2213041; rs2866152; rs6810842; rs9307239

# Metabolic_Enzyme_2_General_References:
3000832; 2935533; 2935875; 2679216; 2547609; 6391920; 3397059; 6374651; 3619918; 1896463; 8201622; 8663387; 11274460; 10733556

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5320

# Metabolic_Enzyme_3_Name:
Aldose reductase

# Metabolic_Enzyme_3_Synonyms:
AR; Aldehyde reductase

# Metabolic_Enzyme_3_Gene_Name:
AKR1B1

# Metabolic_Enzyme_3_Protein_Sequence:
>Aldose reductase
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF

# Metabolic_Enzyme_3_Number_of_Residues:
316

# Metabolic_Enzyme_3_Molecular_Weight:
35854

# Metabolic_Enzyme_3_Theoretical_pI:
6.99

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies

# Metabolic_Enzyme_3_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism

# Metabolic_Enzyme_3_Reaction:
alditol + NAD(P)+ = aldose + NAD(P)H + H+

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.1.1.21

# Metabolic_Enzyme_3_GenBank_ID_Protein:
178487

# Metabolic_Enzyme_3_SwissProt_ID:
ALDR_HUMAN (P15121)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
AKR1B1

# Metabolic_Enzyme_3_Geneatlas_id:
AKR1B1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:381

# Metabolic_Enzyme_3_PDB_ID:
1T40

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>951 bp
ATGGCAAGCCGTCTCCTGCTCAACAACGGCGCCAAGATGCCCATCCTGGGGTTGGGTACC
TGGAAGTCCCCTCCAGGGCAGGTGACTGAGGCCGTGAAGGTGGCCATTGACGTCGGGTAC
CGCCACATCGACTGTGCCCATGTGTACCAGAATGAGAATGAGGTGGGGGTGGCCATTCAG
GAGAAGCTCAGGGAGCAGGTGGTGAAGCGTGAGGAGCTCTTCATCGTCAGCAAGCTGTGG
TGCACGTACCATGAGAAGGGCCTGGTGAAAGGAGCCTGCCAGAAGACACTCAGCGACCTG
AAGCTGGACTACCTGGACCTCTACCTTATTCACTGGCCGACTGGCTTTAAGCCTGGGAAG
GAATTTTTCCCATTGGATGAGTCGGGCAATGTGGTTCCCAGTGACACCAACATTCTGGAC
ACGTGGGCGGCCATGGAAGAGCTGGTGGATGAAGGGCTGGTGAAAGCTATTGGCATCTCC
AACTTCAACCATCTCCAGGTGGAGATGATCTTAAACAAACCTGGCTTGAAGTATAAGCCT
GCAGTTAACCAGATTGAGTGCCACCCATATCTCACTCAGGAGAAGTTAATCCAGTACTGC
CAGTCCAAAGGCATCGTGGTGACCGCCTACAGCCCCCTCGGCTCTCCTGACAGGCCCTGG
GCCAAGCCCGAGGACCCTTCTCTCCTGGAGGATCCCAGGATCAAGGCGATCGCAGCCAAG
CACAATAAAACTACAGCCCAGGTCCTGATCCGGTTCCCCATGCAGAGGAACTTGGTGGTG
ATCCCCAAGTCTGTGACACCAGAACGCATTGCTGAGAACTTTAAGGTCTTTGACTTTGAA
CTGAGCAGCCAGGATATGACCACCTTACTCAGCTACAACAGGAACTGGAGGGTCTGTGCC
TTGTTGAGCTGTACCTCCCACAAGGATTACCCCTTCCATGAAGAGTTTTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
J04795

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_3_Locus:
7q35

# Metabolic_Enzyme_3_SNPs:
rs5054; rs5060; rs5059; rs2229543; rs3087630; rs5055; rs5053; rs1790999; rs1790998; rs1646640; rs4732027; rs2734653; rs3896278; rs2734650; rs10954455; rs1708432; rs10808275; rs17660462; rs2670227; rs11974100; rs2734657; rs2670232; rs1424426; rs2734649; rs2551472; rs2259458; rs17188118; rs12669537; rs2734655; rs7778371; rs1708434; rs11971263; rs2670230; rs10273906; rs17167854; rs2734665; rs969309; rs2701020; rs2734663; rs2734664; rs706207; rs759853; rs17167851; rs918825; rs918824; rs11975656; rs17856148; rs11544687; rs5057; rs4728325; rs5061; rs5062; rs5056; rs17849987; rs1803093; rs3210035; rs11544690; rs13306160; rs1803094; rs1803095; rs2852171; rs2854854; rs2551469; rs3749434; rs2734661; rs2670231; rs2551471; rs1791000; rs2670240; rs2734659; rs2852165; rs2551476; rs3216672; rs2854849; rs7801237; rs2269068; rs10588800; rs35880193; rs2734658; rs34559471; rs2691837; rs1732035; rs2852170; rs2854853; rs2670239; rs1646639; rs2854851; rs5058; rs2551470; rs2670233; rs13306159; rs2854848; rs2701019; rs2734660; rs1732037; rs2852164; rs11417418; rs35431624; rs2852163; rs2269069; rs35632302; rs2852173; rs2854850; rs2551473; rs35338055; rs2691840; rs2852172; rs2734652; rs2852167; rs2854852; rs6963238; rs1791006; rs34569487; rs2670229; rs2551475; rs2691838; rs13306161; rs3216673; rs2974975; rs2551474; rs34678793; rs2551467; rs33945153; rs2852169; rs2734656; rs2854846; rs2734651; rs2691839; rs2734662; rs2852166; rs2691841; rs2551468; rs2691835; rs2551477; rs2691836; rs13306162; rs1708427; rs2852168; rs2670226; rs1621922; rs2852174; rs2551465; rs2691845; rs2551466; rs918826; rs35706999; rs2852176; rs2691846; rs1708404; rs12532832; rs1732039; rs1646636; rs1646642; rs1646637; rs2852175; rs1646641; rs10228986; rs10236262; rs10236468; rs10241645; rs10244489; rs10252030; rs10263438; rs10275865; rs11973239; rs13225343; rs1708414; rs1708415; rs1708416; rs17167841; rs1722900; rs1722911; rs1732038; rs1791001; rs2347375; rs2670228; rs6977866; rs706206; rs7802421; rs782054

# Metabolic_Enzyme_3_General_References:
2498333; 2504709; 2510130; 2111143; 2112546; 1901857; 9195951; 8435445; 2492527; 8343525; 8281941; 8245005; 1621098; 1447221; 8234324; 9405046

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5811

# Metabolic_Enzyme_4_Name:
Aldehyde dehydrogenase 3B1

# Metabolic_Enzyme_4_Synonyms:
Aldehyde dehydrogenase 7

# Metabolic_Enzyme_4_Gene_Name:
ALDH3B1

# Metabolic_Enzyme_4_Protein_Sequence:
>Aldehyde dehydrogenase 3B1
MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE
VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL
TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR
FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA
GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC
GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK
PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD
TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL

# Metabolic_Enzyme_4_Number_of_Residues:
468

# Metabolic_Enzyme_4_Molecular_Weight:
51840

# Metabolic_Enzyme_4_Theoretical_pI:
7.67

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

# Metabolic_Enzyme_4_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_4_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
601780

# Metabolic_Enzyme_4_SwissProt_ID:
AL3B1_HUMAN (P43353)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
ALDH3B1

# Metabolic_Enzyme_4_Geneatlas_id:
ALDH3B1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:410

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>1407 bp
ATGGACCCCCTTGGGGACACGCTGCGGCGACTGCGGGAGGCCTTCCACGCGGGGCGCACG
CGGCCAGCTGAGTTCCGGGCTGCGCAGCTCCAAGGCCTGGGCCGCTTCCTGCAAGAAAAC
AAGCAGCTTCTGCACGACGCACTGGCCCAGGACCTGCACAAGTCAGCCTTCGAGTCGGAG
GTGTCTGAGGTTGCCATCAGCCAGGGCGAGGTCACCCTGGCCCTCAGGAACCTCCGGGCC
TGGATGAAGGACGAGCGTGTGCCCAAGAACCTGGCCACGCAGCTGGACTCCGCCTTCATC
CGGAAGGAGCCCTTTGGCCTGGTCCTCATCATTGCGCCCTGGAACTATCCGCTGAACCTG
ACGCTGGTGCCCCTCGTGGGAGCCCTCGCTGCAGGGAACTGTGTGGTGCTGAAGCCATCG
GAGATTAGCAAGAACGTCGAGAAGATCCTGGCCGAGGTGCTGCCCCAATACGTGGACCAG
AGCTGCTTTGCTGTGGTGCTGGGCGGGCCCCAGGAGACGGGGCAGCTGCTAGAGCACAGG
TTCGACTACATCTTCTTCACAGGGAGCCCTCGTGTGGGCAAGATTGTTATGACTGCTGCC
GCCAAGCACCTGACACCTGTCACCCTGGAGCTGGGGGGCAAGAACCCTTGCTACGTGGAC
GACAACTGCGACCCCCAGACCGTGGCCAACCGCGTGGCCTGGTTCCGCTACTTCAACGCC
GGCCAGACCTGCGTGGCCCCCGACTACGTCCTATGCAGCCCTGAGATGCAGGAGAGGCTG
CTGCCTGCCCTGCAGAGCACCATCACCCGTTTCTATGGCGACGACCCCCAGAGCTCCCCA
AACCTGGGCCGCATCATCAACCAGAAACAGTTCCAGCGGCTGCGGGCATTGCTGGGCTGC
GGCCGTGTGGCCATTGGGGGCCAGAGCGATGAGAGCGATCGCTACATCGCCCCCACGGTG
CTGGTGGATGTGCAGGAGATGGAGCCTGTGATGCAGGAGGAGATCTTCGGGCCCATCCTG
CCCATCGTGAACGTGCAGAGCTTGGACGAGGCCATCGAGTTCATCAACCGGCGGGAGAAG
CCCCTGGCCCTGTACGCCTTCTCCAACAGCAGCCAGGTGGTCAAGCGGGTGCTGACCCAG
ACCAGCAGCGGGGGCTTCTGTGGGAACGACGGCTTCATGCACATGACCCTGGCCAGCCTG
CCTTTTGGAGGAGTGGGTGCCAGTGGGATGGGCCGGTACCATGGCAAGTTCTCCTTCGAC
ACCTTCTCCCACCATCGCGCCTGCCTCCTGCGCAGCCCGGGGATGGAGAAGCTCAACGCC
CTCCGCTACCCGCCGCAATCGCCGCGCCGCCTGAGGATGCTGCTGGTGGCCATGGAGGCC
CAAGGCTGCAGCTGCACACTGCTCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
U10868

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_4_Locus:
11q13

# Metabolic_Enzyme_4_SNPs:
rs572574; rs3764821; rs172620; rs3794181; rs3751081; rs12281209; rs1703440; rs3764818; rs556601; rs2286170; rs1003777; rs308293; rs2286169; rs4646809; rs3764819; rs886702; rs2286163; rs2286164; rs3794177; rs2286165; rs105147; rs2286168; rs2286166; rs308342; rs7125916; rs2286171; rs3794176; rs581105; rs12574760; rs3751082; rs308341; rs34280013; rs475325; rs3764817; rs3751084; rs4244839; rs4646812; rs598156; rs3764816; rs1636207; rs886701; rs11228121; rs308336; rs2010404; rs308335; rs557098; rs308334; rs308338; rs308337; rs3763941; rs737265; rs308333; rs35738719; rs12794336; rs34580830; rs11607185; rs1636208; rs1793238; rs1636209; rs11605214; rs7108283; rs3815220; rs12286110; rs34494820; rs35406834; rs2286167; rs12789057; rs33945294; rs7116695; rs35785905; rs11436139; rs28584816; rs12799330; rs4646808; rs5792429; rs4646813; rs12284146; rs12806003; rs4646811; rs34109111; rs35256233; rs34526809; rs12277180; rs4646810; rs177812; rs34271562; rs8181582; rs11433668; rs7925460; rs34588975; rs34721102; rs7116941; rs3794179; rs12273237; rs34130972; rs5792428; rs7113328; rs34928150; rs7117605; rs35400021; rs11826595; rs1051806; rs1076558; rs10896288; rs1122731; rs11228120; rs11228122; rs11823975; rs11824781; rs11825872; rs12418774; rs12421254; rs12803743; rs1703438; rs1804688; rs191064; rs191065; rs2075626; rs2286172; rs28939679; rs308326; rs308339; rs308340; rs3115545; rs3115546; rs3115548; rs3133266; rs3133267; rs3133269; rs3751085; rs3763942; rs3808969; rs3808970; rs3808971; rs4147776; rs4147777; rs4147778; rs4147780; rs4147782; rs479763; rs7949541; rs7951010; rs7952122; rs884826; rs999571

# Metabolic_Enzyme_4_General_References:
7828891

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5303

# Metabolic_Enzyme_5_Name:
Aldo-keto reductase family 1 member C4

# Metabolic_Enzyme_5_Synonyms:
Chlordecone reductase; CDR; 3-alpha-hydroxysteroid dehydrogenase type I; 3-alpha-HSD1; Dihydrodiol dehydrogenase 4; DD4; HAKRA

# Metabolic_Enzyme_5_Gene_Name:
AKR1C4

# Metabolic_Enzyme_5_Protein_Sequence:
>Aldoketo reductase family 1 member C4
MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP
GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
RNYRYVVMDFLMDHPDYPFSDEY

# Metabolic_Enzyme_5_Number_of_Residues:
323

# Metabolic_Enzyme_5_Molecular_Weight:
37095

# Metabolic_Enzyme_5_Theoretical_pI:
7.19

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3alpha,17beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route

# Metabolic_Enzyme_5_Pathway:
map00120  Bile acid biosynthesis;
 map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_5_Reaction:
chlordecone alcohol + NADP+ = chlordecone + NADPH + H+

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.1.1.225;EC 1.1.1.50

# Metabolic_Enzyme_5_GenBank_ID_Protein:
4261710

# Metabolic_Enzyme_5_SwissProt_ID:
AK1C4_HUMAN (P17516)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
AKR1C4

# Metabolic_Enzyme_5_Geneatlas_id:
AKR1C4

# Metabolic_Enzyme_5_hgnc_id:
HGNC:387

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>972 bp
ATGGATCCCAAATATCAGCGTGTAGAGCTAAATGATGGTCATTTCATGCCCGTATTGGGA
TTTGGCACCTATGCACCTCCAGAGGTTCCGAGGAACAGAGCTGTAGAGGTCACCAAATTA
GCAATAGAAGCTGGCTTCCGCCATATTGATTCTGCTTATTTATACAATAATGAGGAGCAG
GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTC
TACACTTCAAAGCTTTGGTGCACTTTCTTTCAACCACAGATGGTCCAACCAGCCTTGGAA
AGCTCACTGAAAAAACTTCAACTGGACTATGTTGACCTCTATCTTCTTCATTTCCCAATG
GCTCTCAAGCCAGGTGAGACGCCACTACCAAAAGATGAAAATGGAAAAGTAATATTCGAC
ACAGTGGATCTCTCTGCCACATGGGAGGTCATGGAGAAGTGTAAGGATGCAGGATTGGCC
AAGTCCATCGGGGTGTCAAACTTCAACTGCAGGCAGCTGGAGATGATCCTCAACAAGCCA
GGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCTTACCTCAACCAGAGC
AAACTGCTGGATTTCTGCAAGTCAAAAGACATTGTTCTGGTTGCCCACAGTGCTCTGGGA
ACCCAACGACATAAACTATGGGTGGACCCAAACTCCCCAGTTCTTTTGGAGGACCCAGTT
CTTTGTGCCTTAGCAAAGAAACACAAACGAACCCCAGCCCTGATTGCCCTGCGCTACCAG
CTGCAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGGATCAGAGAGAAC
ATCCAGGTTTTTGAATTCCAGTTGACATCAGAGGATATGAAAGTTCTAGATGGTCTAAAC
AGAAATTATCGATATGTTGTCATGGATTTTCTTATGGACCATCCTGATTATCCATTTTCA
GATGAATATTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
S68287

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_5_Locus:
10p15-p14

# Metabolic_Enzyme_5_SNPs:
rs3829125; rs17134592; rs11253043; rs17306779; rs2398157; rs17307359; rs1413622; rs10458795; rs1931679; rs7085249; rs1413781; rs1413624; rs2050308; rs7921838; rs7088788; rs6601927; rs4881412; rs6601924; rs7078211; rs12247748; rs11594448; rs7101071; rs17134526; rs7092102; rs3750572; rs10795255; rs3750569; rs12762017; rs1413780; rs2225695; rs3750567; rs7070862; rs1832007; rs10904440; rs10795256; rs3750568; rs3750571; rs7074004; rs1889457; rs4881413; rs7475281; rs7908297; rs11253046; rs7475279; rs17134531; rs7083869; rs7897431; rs1334475; rs2151896; rs7087111; rs17134533; rs1334474; rs11594520; rs12257364; rs17134589; rs4881411; rs11594428; rs4098025; rs17134585; rs11253045; rs7477230; rs17134523; rs34463109; rs34030369; rs11253042; rs7100517; rs12771394; rs1831977; rs11253041; rs2398160; rs1334473; rs2210681; rs7477114; rs7893850; rs36048054; rs11596429; rs3996505; rs7099303; rs4478889; rs4427472; rs11253047; rs2095367; rs12264733; rs7099651; rs2050309; rs4612705; rs35950499; rs17134588; rs12252186; rs4880716; rs6601928; rs7072596; rs17134601; rs11253048; rs17134604; rs4880718; rs17851824; rs3038974; rs1413623; rs35960357; rs11327365; rs11268534; rs2398158; rs3039101; rs7096122; rs3750570; rs2398159; rs5782814; rs11253044; rs35917693; rs10600924; rs9423555; rs4350268; rs7909380; rs10586998; rs7915357; rs41305665; rs4420164; rs4424574; rs5782812; rs4642979; rs915135; rs34826816; rs12784055; rs3039090; rs35154936; rs2151895; rs35283379; rs1334472; rs7912751; rs7909379; rs2104997; rs5782813; rs12776936; rs2065661; rs10458789; rs34351269; rs11253040; rs1811960; rs3812617; rs11402533; rs12774775; rs10711188; rs11291778; rs11427518; rs3841204; rs3812616; rs10795253; rs10904441; rs10904442; rs11253038; rs12253078; rs12267307; rs12269559; rs12360316; rs12775790; rs1334466; rs17134607; rs17134608; rs17134610; rs17134614; rs17134616; rs17134617; rs17155741; rs17306485; rs1889456; rs1931681; rs2151901; rs6422393; rs6601929; rs7091223; rs7096360; rs9423382

# Metabolic_Enzyme_5_General_References:
8274401; 7650035; 7626489; 10634139; 10672042; 11158055; 2187532; 8172617; 1530633

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5305

# Metabolic_Enzyme_6_Name:
Dehydrogenase/reductase SDR family member 4

# Metabolic_Enzyme_6_Synonyms:
NADPH- dependent carbonyl reductase/NADP-retinol dehydrogenase; CR; PHCR; Peroxisomal short-chain alcohol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase; NDRD; SCAD-SRL; humNRDR; PSCD

# Metabolic_Enzyme_6_Gene_Name:
DHRS4

# Metabolic_Enzyme_6_Protein_Sequence:
>Dehydrogenase/reductase SDR family member 4
MASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQG
EGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTL
DINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAI
ELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSE
DASYITGETVVVGGGTPSRL

# Metabolic_Enzyme_6_Number_of_Residues:
260

# Metabolic_Enzyme_6_Molecular_Weight:
27572

# Metabolic_Enzyme_6_Theoretical_pI:
7.96

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones

# Metabolic_Enzyme_6_Pathway:
map00590  Prostaglandin and leukotriene metabolism

# Metabolic_Enzyme_6_Reaction:
R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.1.1.184

# Metabolic_Enzyme_6_GenBank_ID_Protein:
4105190

# Metabolic_Enzyme_6_SwissProt_ID:
DHRS4_HUMAN (Q9BTZ2)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
DHRS4

# Metabolic_Enzyme_6_Geneatlas_id:
DHRS4

# Metabolic_Enzyme_6_hgnc_id:
HGNC:16985

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_6_Gene_Sequence:
>783 bp
ATGGCCAGCTCCGGGATGACCCGCCGGGACCCGCTCGCAAATAAGGTGGCCCTGGTAACG
GCCTCCACCGACGGGATCGGCTTCGCCATCGCCCGGCGTTTGGCCCAGGACGGGGCCCAT
GTGGTCGTCAGCAGCCGGAAGCAGCAGAATGTGGACCAGGCGGTGGCCACGCTGCAGGGG
GAGGGGCTGAGCGTGACGGGCACCGTGTGCCATGTGGGGAAGGCGGAGGACCGGGAGCGG
CTGGTGGCCATGGCTGTGAAGCTTCATGGAGGTATCGATATCCTAGTCTCCAATGCTGCT
GTCAACCCTTTCTTTGGAAGCCTAATGGATGTCACTGAGGAGGTGTGGGACAAGACTCTG
GACATTAATGTGAAGGCCCCAGCCCTGATGACAAAGGCAGTGGTGCCAGAAATGGAGAAA
CGAGGAGGCGGCTCAGTGGTGATCGTGTCTTCCATAGCAGCCTTCAGTCCATCTCCTGGC
TTCAGTCCTTACAATGTCAGTAAAACAGCCTTGCTGGGCCTGACCAAGACCCTGGCCATA
GAGCTGGCCCCAAGGAACATTAGGGTGAACTGCCTAGCACCTGGACTTATCAAGACTAGC
TTCAGCAGGATGCTCTGGATGGACAAGGAAAAAGAGGAAAGCATGAAAGAAACCCTGCGG
ATAAGAAGGTTAGGCGAGCCAGAGGATTGTGCTGGCATCGTGTCTTTCCTGTGCTCTGAA
GATGCCAGCTACATCACTGGGGAAACAGTGGTGGTGGGTGGAGGAACCCCGTCCCGCCTC
TGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AF044127

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_6_Locus:
14q11.2

# Metabolic_Enzyme_6_SNPs:
rs1043442; rs17099455; rs2273944; rs12147221; rs4457918; rs1885805; rs1885808; rs8009599; rs8010151; rs2984817; rs10137990; rs6573484; rs7153422; rs6573488; rs3742491; rs10140455; rs6573486; rs6573487; rs10151581; rs6573485; rs1961181; rs11848292; rs11844505; rs11158474; rs8009022; rs3742493; rs11845361; rs10141263; rs7153513; rs1957688; rs1885807; rs3742494; rs1885806; rs8012155; rs3742492; rs11158470; rs1951737; rs1951736; rs17099424; rs10148823; rs10141091; rs10149094; rs4048586; rs10137992; rs10151793; rs1043438; rs1043437; rs1043440; rs1127276; rs1043650; rs1127278; rs1043439; rs1043446; rs11556285; rs4981491; rs3211118; rs28437269; rs3742495; rs2181423; rs28800275; rs8007763; rs28635008; rs28373485; rs35952435; rs35550020; rs7154783; rs35298187; rs1957687; rs28871625; rs33966071; rs2332156; rs35429464; rs34506026; rs11844693; rs5807245; rs2011740; rs7156226; rs2332157; rs13379296; rs6573483; rs28477540; rs35656062; rs28687936; rs2146573; rs28879726; rs4982825; rs2146574; rs35657085; rs34929257; rs35631264; rs28620370; rs2332145; rs4048597; rs35183145; rs2019493; rs4048602; rs2332123; rs4048598; rs10140992; rs10149300; rs2011934; rs10148822; rs2332118; rs2332124; rs4048601; rs3049857; rs4048599; rs4048603; rs1815263; rs3049828; rs6573471; rs7152712

# Metabolic_Enzyme_6_General_References:
10333503; 12975309

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5431

# Metabolic_Enzyme_7_Name:
Retinal dehydrogenase 1

# Metabolic_Enzyme_7_Synonyms:
RalDH1; RALDH 1; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; ALHDII; ALDH-E1

# Metabolic_Enzyme_7_Gene_Name:
ALDH1A1

# Metabolic_Enzyme_7_Protein_Sequence:
>Retinal dehydrogenase 1
MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV
DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL
NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI
GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID
KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG
QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES
GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR
ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE
YGFHEYTEVKTVTVKISQKNS

# Metabolic_Enzyme_7_Number_of_Residues:
501

# Metabolic_Enzyme_7_Molecular_Weight:
54862

# Metabolic_Enzyme_7_Theoretical_pI:
6.71

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_7_Specific_Function:
Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid

# Metabolic_Enzyme_7_Pathway:
map00830  Retinol metabolism;
GENES       HSA: 216(ALDH1A1) 8854(ALDH1A2);
            MMU: 11668(Aldh1a1) 19378(Aldh1a2);
            RNO: 116676(Aldh1a2) 24188(Aldh1a1);
            DRE: 116713(aldh1a2)

# Metabolic_Enzyme_7_Reaction:
retinal + NAD+ + H2O = retinoate + NADH + H+

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.2.1.36

# Metabolic_Enzyme_7_GenBank_ID_Protein:
178372

# Metabolic_Enzyme_7_SwissProt_ID:
AL1A1_HUMAN (P00352)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
ALDH1A1

# Metabolic_Enzyme_7_Geneatlas_id:
ALDH1A1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:402

# Metabolic_Enzyme_7_PDB_ID:
1BXS

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_7_Gene_Sequence:
>1506 bp
ATGTCATCCTCAGGCACGCCAGACTTACCTGTCCTACTCACCGATTTGAAGATTCAATAT
ACTAAGATCTTCATAAACAATGAATGGCATGATTCAGTGAGTGGCAAGAAATTTCCTGTC
TTTAATCCTGCAACTGAGGAGGAGCTCTGCCAGGTAGAAGAAGGAGATAAGGAGGATGTT
GACAAGGCAGTGAAGGCCGCAAGACAGGCTTTTCAGATTGGATCTCCGTGGCGTACTATG
GATGCTTCCGAGAGGGGGCGACTATTATACAAGTTGGCTGATTTAATCGAAAGAGATCGT
CTGCTGCTGGCGACAATGGAGTCAATGAATGGTGGAAAACTCTATTCCAATGCATATCTG
AATGATTTAGCAGGCTGCATCAAAACATTGCGCTACTGTGCAGGTTGGGCTGACAAGATC
CAGGGCCGTACAATACCAATTGATGGAAATTTTTTTACATATACAAGACATGAACCTATT
GGTGTATGTGGCCAAATCATTCCTTGGAATTTCCCGTTGGTTATGCTCATTTGGAAGATA
GGGCCTGCACTGAGCTGTGGAAACACAGTGGTTGTCAAACCAGCAGAGCAAACTCCTCTC
ACTGCTCTCCACGTGGCATCTTTAATAAAAGAGGCAGGGTTTCCTCCTGGAGTAGTGAAT
ATTGTTCCTGGTTATGGGCCTACAGCAGGGGCAGCCATTTCTTCTCACATGGATATAGAC
AAAGTAGCCTTCACAGGATCAACAGAGGTTGGCAAGTTGATCAAAGAAGCTGCCGGGAAA
AGCAATCTGAAGAGGGTGACCCTGGAGCTTGGAGGAAAGAGCCCTTGCATTGTGTTAGCT
GATGCCGACTTGGACAATGCTGTTGAATTTGCACACCATGGGGTATTCTACCACCAGGGC
CAGTGTTGTATAGCCGCATCCAGGATTTTTGTGGAAGAATCAATTTATGATGAGTTTGTT
CGAAGGAGTGTTGAGCGGGCTAAGAAGTATATCCTTGGAAATCCTCTGACCCCAGGAGTC
ACTCAAGGCCCTCAGATTGACAAGGAACAATATGATAAAATACTTGACCTCATTGAGAGT
GGGAAGAAAGAAGGGGCCAAACTGGAATGTGGAGGAGGCCCGTGGGGGAATAAAGGCTAC
TTTGTCCAGCCCACAGTGTTCTCTAATGTTACAGATGAGATGCGCATTGCCAAAGAGGAG
ATTTTTGGACCAGTGCAGCAAATCATGAAGTTTAAATCTTTAGATGACGTGATCAAAAGA
GCAAACAATACTTTCTATGGCTTATCAGCAGGAGTGTTTACCAAAGACATTGATAAAGCC
ATAACAATCTCCTCTGCTCTGCAGGCAGGAACAGTGTGGGTGAATTGCTATGGCGTGGTA
AGTGCCCAGTGCCCCTTTGGTGGATTCAAGATGTCTGGAAATGGAAGAGAACTGGGAGAG
TACGGTTTCCATGAATATACAGAGGTCAAAACAGTCACAGTGAAAATCTCTCAGAAGAAC
TCATAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
M31994

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_7_Locus:
9q21.13

# Metabolic_Enzyme_7_SNPs:
rs8187929; rs13959; rs8187999; rs8187998; rs8188000; rs1330286; rs348449; rs2288087; rs1888202; rs348461; rs348458; rs348462; rs348463; rs1469167; rs1424482; rs2773806; rs647880; rs348457; rs3764435; rs348455; rs1888203; rs348460; rs610529; rs8187924; rs10781106; rs2309779; rs2210103; rs3909559; rs1330291; rs4237254; rs11143419; rs1424487; rs63319; rs7027604; rs7043217; rs8187981; rs4646547; rs2161811; rs1424488; rs12000845; rs8187906; rs348459; rs8187902; rs595958; rs348450; rs8187893; rs8187940; rs8187878; rs8187927; rs7871253; rs8187976; rs8187895; rs8187919; rs348471; rs348477; rs7870836; rs348472; rs8187884; rs8187972; rs8187973; rs348454; rs2303317; rs348475; rs7851899; rs8187945; rs8187978; rs2161810; rs8187909; rs8187887; rs3739962; rs8187961; rs1330282; rs1330285; rs8187922; rs8187993; rs4744674; rs8187898; rs1928848; rs168351; rs8187942; rs8187876; rs190227; rs8187891; rs17058219; rs3780833; rs8187890; rs4646540; rs8187925; rs722921; rs4237253; rs8187871; rs3815836; rs8187923; rs8187963; rs348456; rs4646543; rs4646544; rs4237255; rs8187950; rs5898284; rs2017362; rs2288086; rs8187934; rs8187996; rs12684937; rs8187983; rs17058224; rs8187935; rs8187916; rs8187920; rs8187939; rs17648566; rs8187930; rs8187949; rs8187875; rs8187910; rs8187931; rs189432; rs8187966; rs8187967; rs8187977; rs8187951; rs8187941; rs7852860; rs11143410; rs8187962; rs8187905; rs8187873; rs8187912; rs8187958; rs8187965; rs8187901; rs8187896; rs8187932; rs8187988; rs8187928; rs8187955; rs8187868; rs12683230; rs768254; rs8187914; rs4567103; rs8187974; rs12347296; rs8187882; rs348453; rs8187943; rs186997; rs348476; rs1364457; rs348473; rs8187989; rs8187872; rs8187970; rs8187947; rs8187897; rs8187913; rs7037994; rs7874767; rs8187984; rs8187946; rs8187956; rs8187975; rs8187903; rs8187881; rs8187869; rs8187969; rs348474; rs348452; rs10869199; rs7027713; rs8187948; rs8187938; rs8187874; rs8187968; rs8187953; rs8187889; rs3739960; rs348482; rs348481; rs8188001; rs17058197; rs348485; rs8188002; rs4646548; rs348484; rs348445; rs348480; rs348483; rs8187865; rs6151031; rs8187864; rs8187866; rs1803054; rs1063447; rs1049981; rs11554424; rs11554423; rs11554426; rs11554422; rs34476430; rs15500; rs8187867; rs2480918; rs4070551; rs5898277; rs35965674; rs11143411; rs12683758; rs8187870; rs662728; rs13294308; rs13296161; rs7853294; rs34939955; rs12000418; rs4070547; rs3970137; rs8187995; rs35554394; rs12339821; rs8187957; rs8187971; rs13302421; rs8187888; rs8187992; rs5898285; rs34704107; rs13293836; rs7868275; rs8187987; rs11143418; rs33988381; rs8187954; rs28450146; rs11143421; rs8187885; rs34299574; rs8187936; rs35283357; rs35871415; rs34765286; rs4646546; rs1411425; rs3079025; rs5898276; rs8187980; rs34878833; rs5898280; rs8187921; rs4070548; rs8187918; rs8187894; rs13294172; rs2113458; rs7470175; rs11143409; rs4646539; rs11325184; rs8187991; rs35717410; rs35500367; rs11459106; rs8187877; rs4646541; rs8187994; rs11327072; rs35095299; rs35665439; rs34289326; rs35870093; rs8187917; rs4070545; rs8187883; rs8187985; rs8187904; rs5898281; rs10610423; rs8187959; rs3079046; rs4070553; rs8187900; rs5898279; rs35382115; rs8187911; rs4646545; rs8187964; rs4070550; rs8187952; rs8187960; rs8187937; rs4070549; rs8187979; rs34812942; rs8187908; rs35186484; rs36001809; rs8187986; rs35839136; rs4990322; rs34872376; rs34216366; rs191549; rs34117615; rs10670898; rs8187990; rs8187933; rs8187982; rs35843379; rs34995395; rs5898282; rs33965511; rs13294502; rs8187944; rs13296621; rs8187886; rs34286887; rs8187997; rs4070546; rs13294503; rs8187899; rs34234055; rs8187892; rs4070552; rs959669; rs5898278; rs8187880; rs11143420; rs11349565; rs34403014; rs348451; rs8187926; rs12682966; rs35104046; rs11360055; rs8187879; rs5898275; rs13294544; rs8187907; rs6151030; rs12342202; rs41316480; rs33997596; rs8188003; rs35774924; rs33979949; rs5898283; rs10869197; rs10869198; rs11787668; rs11999628; rs12002950; rs12350584; rs13287937; rs1330284; rs34410204; rs34464617; rs348447; rs348448; rs348478; rs348479; rs610487; rs617590; rs618596; rs622739; rs687428; rs694564; rs7873724; rs9411067

# Metabolic_Enzyme_7_General_References:
2591967; 8214422; 6723659; 2987944; 4015823; 3676276; 2776714; 8493914

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5532

# Metabolic_Enzyme_8_Name:
Aldehyde dehydrogenase X, mitochondrial precursor

# Metabolic_Enzyme_8_Synonyms:
Aldehyde dehydrogenase family 1 member B1; ALDH class 2

# Metabolic_Enzyme_8_Gene_Name:
ALDH1B1

# Metabolic_Enzyme_8_Protein_Sequence:
>Aldehyde dehydrogenase X, mitochondrial precursor
MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT
TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNLLADLVERDRVYLA
SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCG
QIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITG
YGPTAGAAIAQHMDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADM
EHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGP
QVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP
VQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHT
PFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS

# Metabolic_Enzyme_8_Number_of_Residues:
517

# Metabolic_Enzyme_8_Molecular_Weight:
57239

# Metabolic_Enzyme_8_Theoretical_pI:
6.79

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_8_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation

# Metabolic_Enzyme_8_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_8_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_8_Signals:
1-22

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_8_GenBank_ID_Protein:
1263008

# Metabolic_Enzyme_8_SwissProt_ID:
AL1B1_HUMAN (P30837)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
ALDH1B1

# Metabolic_Enzyme_8_Geneatlas_id:
ALDH1B1

# Metabolic_Enzyme_8_hgnc_id:
HGNC:407

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_8_Gene_Sequence:
>1554 bp
ATGCTGCGCTTCCTGGCACCCCGGCTGCTTAGCCTCCAGGGCAGGACCGCCCTCTACTCC
TCGGCAGCAGCCCTCCCAAGCCCCATTCTGAACCCAGACATCCCCTACAACCAGCTGTTC
ATCAACAATGAATGGCAAGATGCAGTCAGCAAGAAGACCTTCCCGACGGTCAACCCTACC
ACCGGGGAGGTCATCGGGCACGTGGCTGAAGGTGACCGGGCTGATGTGGATCGGGCCGTG
AAAGCAGCCCGGGAAGCCTTCCGCCTGGGGTCCCCATGGCGCCGGATGGATGCCTCTGAG
CGGGGCCGGCTGCTGAACCTCCTGGCAGACCTAGTGGAGCGGGATCGAGTCTACTTGGCC
TCACTCGAGACCTTGGACAATGGGAAGCCTTTCCAAGAGTCTTACGCCTTGGACTTGGAT
GAGGTCATCAAGGTGTATCGGTACTTTGCTGGCTGGGCTGACAAGTGGCATGGCAAGACC
ATCCCCATGCATGGCCAGCATTTCTGCTTCACCCGGCATGAGCCCGTTGGTGTCTGTGGC
CAGATCATCCCGTGGAACTTCCCCTTGGTCATGCAGGGTTGGAAACTTGCCCCGGCACTC
GCCACAGGCAACACTGTGGTTATGAAGGTGGCAGAGCAGACCCCCCTCTCTGCCCTGTAT
TTGGCCTCCCTCATCAAGGAGGCAGGCTTTCCCCCTGGGGTGGTGAACATCATCACGGGG
TATGGCCCAACAGCAGGTGCGGCCATCGCCCAGCACATGGATGTTGACAAAGTTGCCTTC
ACCGGTTCCACCGAGGTGGGCCACCTGATCCAGAAAGCAGCTGGCGATTCCAACCTCAAG
AGAGTCACCCTGGAGCTGGGTGGTAAGAGCCCCAGCATCGTGCTGGCCGATGCTGACATG
GAGCATGCCGTGGAGCAGTGCCACGAAGCCCTGTTCTTCAACATGGGCCAGTGCTGCTGT
GCTGGCTCCCGGACCTTCGTGGAAGAATCCATCTACAATGAGTTTCTCGAGAGAACCGTG
GAGAAAGCAAAGCAGAGGAAAGTGGGGAACCCCTTTGAGCTGGACACCCAGCAGGGGCCT
CAGGTGGACAAGGAGCAGTTTGAACGAGTCCTAGGCTACATCCAGCTTGGCCAGAAGGAG
GGCGCAAAACTCCTCTGTGGCGGAGAGCGTTTCGGGGAGCGTGGTTTCTTCATCAAGCCT
ACTGTCTTTGGTGGCGTGCAGGATGACATGAGAATTGCCAAAGAGGAGATCTTTGGGCCT
GTGCAGCCCCTGTTCAAGTTCAAGAAGATTGAGGAGGTGGTTGAGAGGGCCAACAACACC
AGGTATGGCCTGGCTGCGGCTGTGTTCACCCGGGATCTGGACAAGGCCATGTACTTCACC
CAGGCACTCCAGGCCGGGACCGTGTGGGTAAACACCTACAACATCGTCACCTGCCACACG
CCATTTGGAGGGTTTAAGGAATCTGGAAACGGGAGGGAGCTGGGTGAGGATGGGCTTAAG
GCCTACACAGAGGTAAAGACGGTCACCATCAAGGTTCCTCAGAAGAACTCGTAA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
M63967

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_8_Locus:
9p11.1

# Metabolic_Enzyme_8_SNPs:
rs2228093; rs4878199; rs2073478; rs2073477; rs2228094; rs3043; rs6476701; rs10758494; rs10758495; rs7859877; rs4646772; rs4646774; rs4878802; rs10738997; rs11555705; rs4646773; rs41278335; rs11555706; rs10973781; rs10973782; rs12343271; rs41278337; rs10118683; rs10758496; rs10814687; rs10973774; rs10973779; rs10973783; rs10973785; rs10973786; rs10973787; rs10973789; rs10973792; rs11361; rs11790480; rs11791018; rs11791622; rs12001093; rs12336048; rs12352007; rs12378762; rs13285234; rs13290293; rs1555480; rs1923423; rs1923424; rs2038589; rs34183602; rs35950473; rs4142260; rs4242647; rs4878203; rs4878800; rs4878801; rs4878804; rs4878805; rs4878806; rs4878807; rs4878808; rs4878809; rs4878811; rs6476703; rs7021469; rs7031628; rs7045542; rs7046137; rs7853954; rs7865905; rs7866277; rs7867383; rs911757; rs911758

# Metabolic_Enzyme_8_General_References:
2061311; 8244338

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
6063

# Metabolic_Enzyme_9_Name:
Alcohol dehydrogenase class 4 mu/sigma chain

# Metabolic_Enzyme_9_Synonyms:
Alcohol dehydrogenase class IV mu/sigma chain; Retinol dehydrogenase; Gastric alcohol dehydrogenase

# Metabolic_Enzyme_9_Gene_Name:
ADH7

# Metabolic_Enzyme_9_Protein_Sequence:
>Alcohol dehydrogenase class 4 mu/sigma chain
MGTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVS
KFPVIVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGR
GVLADGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGY
GAAVKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATEC
ISPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSAKM
LTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITHVLPFKKISEGFE
LLNSGQSIRTVLTF

# Metabolic_Enzyme_9_Number_of_Residues:
374

# Metabolic_Enzyme_9_Molecular_Weight:
40006

# Metabolic_Enzyme_9_Theoretical_pI:
8.08

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_9_Specific_Function:
Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism

# Metabolic_Enzyme_9_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_9_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_9_GenBank_ID_Protein:
516618

# Metabolic_Enzyme_9_SwissProt_ID:
ADH7_HUMAN (P40394)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
ADH7

# Metabolic_Enzyme_9_Geneatlas_id:
ADH7

# Metabolic_Enzyme_9_hgnc_id:
HGNC:256

# Metabolic_Enzyme_9_PDB_ID:
1D1S

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_9_Gene_Sequence:
>1125 bp
ATGGGCACTGCTGGAAAAGTTATTAAGTGCAAAGCAGCTGTGCTTTGGGAGCAGAAGCAA
CCCTTCTCCATTGAGGAAATAGAAGTTGCCCCACCAAAGACTAAAGAAGTTCGCATTAAG
ATTTTGGCCACAGGAATCTGTCGCACAGATGACCATGTGATAAAAGGAACAATGGTGTCC
AAGTTTCCAGTGATTGTGGGACATGAGGCAACTGGGATTGTAGAGAGCATTGGAGAAGGA
GTGACTACAGTGAAACCAGGTGACAAAGTCATCCCTCTCTTTCTGCCACAATGTAGAGAA
TGCAATGCTTGTCGCAACCCAGATGGCAACCTTTGCATTAGGAGCGATATTACTGGTCGT
GGAGTACTGGCTGATGGCACCACCAGATTTACATGCAAGGGCAAACCAGTCCACCACTTC
ATGAACACCAGTACATTTACCGAGTACACAGTGGTGGATGAATCTTCTGTTGCTAAGATT
GATGATGCAGCTCCTCCTGAGAAAGTCTGTTTAATTGGCTGTGGGTTTTCCACTGGATAT
GGCGCTGCTGTTAAAACTGGCAAGGTCAAACCTGGTTCCACTTGCGTCGTCTTTGGCCTG
GGAGGAGTTGGCCTGTCAGTCATCATGGGCTGTAAGTCAGCTGGTGCATCTAGGATCATT
GGGATTGACCTCAACAAAGACAAATTTGAGAAGGCCATGGCTGTAGGTGCCACTGAGTGT
ATCAGTCCCAAGGACTCTACCAAACCCATCAGTGAGGTGCTGTCAGAAATGACAGGCAAC
AACGTGGGATACACCTTTGAAGTTATTGGGCATCTTGAAACCATGATTGATGCCCTGGCA
TCCTGCCACATGAACTATGGGACCAGCGTGGTTGTAGGAGTTCCTCCATCAGCCAAGATG
CTCACCTATGACCCGATGTTGCTCTTCACTGGACGCACATGGAAGGGATGTGTCTTTGGA
GGTTTGAAAAGCAGAGATGATGTCCCAAAACTAGTGACTGAGTTCCTGGCAAAGAAATTT
GACCTGGACCAGTTGATAACTCATGTTTTACCATTTAAAAAAATCAGTGAAGGATTTGAG
CTGCTCAATTCAGGACAAAGCATTCGAACGGTCCTGACGTTTTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
L33179

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_9_Locus:
4q23-q24

# Metabolic_Enzyme_9_SNPs:
rs1573496; rs971074; rs894369; rs284787; rs3805331; rs3805329; rs284786; rs4147554; rs17029033; rs17537595; rs1154456; rs284784; rs1154460; rs284785; rs2584464; rs1154467; rs1154459; rs4147549; rs1154458; rs2851011; rs1827567; rs1154457; rs12504511; rs284779; rs930478; rs1154461; rs1154455; rs1154454; rs1229797; rs1154464; rs4147553; rs1154469; rs2851297; rs17529377; rs7693230; rs284798; rs17588403; rs17588761; rs17029037; rs1154468; rs3737482; rs17529509; rs12499297; rs2584465; rs4147552; rs17029035; rs12502365; rs12510051; rs17529530; rs1154470; rs729147; rs284789; rs1154453; rs284790; rs2851012; rs4147555; rs2654847; rs1154471; rs284797; rs1042111; rs34907712; rs1154462; rs34061749; rs35268476; rs28418615; rs2866159; rs34652525; rs35672109; rs36008509; rs2866158; rs28712290; rs34555199; rs1154466; rs11480228; rs4147551; rs11359125; rs35475511; rs4147550; rs35065328; rs35006747; rs1154465; rs36166167; rs34553961; rs2860159; rs4318659; rs7690256; rs13137887; rs34682744; rs2851031; rs2866160; rs12502381; rs13146108; rs35816713; rs1154463; rs6831961; rs36084955; rs2851030; rs34925826; rs422143; rs33995120; rs2851028; rs34216119; rs3076141; rs2851296; rs2584463; rs34090033; rs377582; rs1154452; rs284788; rs34457649; rs34867051; rs437106; rs10020840; rs1154472; rs1154473; rs1154474; rs1154475; rs1154476; rs1154477; rs1154480; rs1154481; rs1154483; rs13104075; rs1348276; rs1442477; rs1442488; rs1442489; rs1442490; rs1553434; rs17028991; rs17587689; rs2083687; rs2083688; rs2099855; rs2202291; rs2584462; rs2654848; rs284791; rs284792; rs284793; rs2851295; rs400144; rs4699382; rs7435475; rs7663410; rs7668420; rs7696921; rs969804; rs994771; rs994772

# Metabolic_Enzyme_9_General_References:
8195208; 7876191; 7925371; 8082805; 7876099; 7771649; 1592118; 9228021

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5810

# Metabolic_Enzyme_10_Name:
Aldehyde dehydrogenase 3B2

# Metabolic_Enzyme_10_Synonyms:
Aldehyde dehydrogenase 8

# Metabolic_Enzyme_10_Gene_Name:
ALDH3B2

# Metabolic_Enzyme_10_Protein_Sequence:
>Aldehyde dehydrogenase 3B2
MKDEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGNCVVLKPSE
ISQGTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAAT
KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLL
PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVL
VDVQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERT
SSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEI
RYPPYTDWNQQLLRWGMGSQSCTLL

# Metabolic_Enzyme_10_Number_of_Residues:
385

# Metabolic_Enzyme_10_Molecular_Weight:
42670

# Metabolic_Enzyme_10_Theoretical_pI:
5.97

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_10_Specific_Function:
An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

# Metabolic_Enzyme_10_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_10_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_10_GenBank_ID_Protein:
1051281

# Metabolic_Enzyme_10_SwissProt_ID:
AL3B2_HUMAN (P48448)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
ALDH3B2

# Metabolic_Enzyme_10_Geneatlas_id:
ALDH3B2

# Metabolic_Enzyme_10_hgnc_id:
HGNC:411

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Not Available

# Metabolic_Enzyme_10_Gene_Sequence:
>1158 bp
ATGAAGGATGAACCACGGTCCACGAACCTGTTCATGAAGCTGGACTCGGTCTTCATCTGG
AAGGAACCCTTTGGCCTGGTCCTCATCATCGCACCCTGGAACTACCCATTGAACCTGACC
CTGGTGCTCCTGGTGGGCACCCTCCCCGCAGGGAATTGCGTGGTGCTGAAGCCGTCAGAA
ATCAGCCAGGGCACAGAGAAGGTCCTGGCTGAGGTGCTGCCCCAGTACCTGGACCAGAGC
TGCTTTGCCGTGGTGCTGGGCGGACCCCAGGAGACAGGGCAGCTGCTAGAGCACAAGTTG
GACTACATCTTCTTCACAGGGAGCCCTCGTGTGGGCAAGATTGTCATGACTGCTGCCACC
AAGCACCTGACGCCTGTCACCCTGGAGCTGGGGGGCAAGAACCCCTGCTACGTGGACGAC
AACTGCGACCCCCAGACCGTGGCCAACCGCGTGGCCTGGTTCTGCTACTTCAATGCCGGC
CAGACCTGCGTGGCCCCTGACTACGTCCTGTGCAGCCCCGAGATGCAGGAGAGGCTGCTG
CCCGCCCTGCAGAGCACCATCACCCGTTTCTATGGCGACGACCCCCAGAGCTCCCCAAAC
CTGGGCCGCATCATCAACCAGAAACAGTTCCAGCGGCTGCGGGCATTGCTGGGCTGCGGC
CGCGTGGCCATTGGGGGCCAGAGCAACGAGAGCGATCGCTACATCGCCCCCACGGTGCTG
GTGGACGTGCAGGAGACGGAGCCTGTGATGCAGGAGGAGATCTTCGGGCCCATCCTGCCC
ATCGTGAACGTGCAGAGCGTGGACGAGGCCATCAAGTTCATCAACCGGCAGGAGAAGCCC
CTGGCCCTGTACGCCTTCTCCAACAGCAGACAGGTTGTGAACCAGATGCTGGAGCGGACC
AGCAGCGGCAGCTTTGGAGGCAATGAGGGCTTCACCTACATATCTCTGCTGTCCGTGCCA
TTCGGGGGAGTCGGCCACAGTGGGATGGGCCGGTACCACGGCAAGTTCACCTTCGACACC
TTCTCCCACCACCGCACCTGCCTGCTCGCCCCCTCCGGCCTGGAGAAATTAAAGGAGATC
CGCTACCCACCCTATACCGACTGGAACCAGCAGCTGTTACGCTGGGGCATGGGCTCCCAG
AGCTGCACCCTCCTGTGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
U37519

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_10_Locus:
11q13

# Metabolic_Enzyme_10_SNPs:
rs3741178; rs1551888; rs4646826; rs6591270; rs1551886; rs3741172; rs2279123; rs2279124; rs17510687; rs4313593; rs3127; rs1551885; rs3808972; rs2279125; rs1903829; rs866907; rs7947978; rs11823098; rs7114210; rs2514061; rs2251277; rs6591274; rs6591273; rs4646823; rs3825021; rs28372760; rs2279126; rs6591272; rs7947754; rs5019163; rs1871031; rs4930471; rs2514063; rs4569014; rs4930472; rs12295420; rs2251281; rs10791909; rs9787887; rs6591271; rs9736142; rs3741179; rs2514060; rs4930465; rs1551887; rs1871032; rs1979376; rs1979375; rs11603033; rs6591269; rs7934566; rs11821703; rs2514056; rs2514057; rs1140670; rs2447571; rs12292126; rs1131740; rs12278968; rs17856219; rs1051493; rs4646818; rs2514019; rs4587733; rs7483770; rs4646821; rs28887499; rs2447570; rs2514058; rs35431164; rs7944424; rs34589365; rs3191912; rs2514059; rs34763154; rs2514062; rs4930474; rs4646820; rs4581451; rs4646822; rs35843427; rs34926854; rs34057662; rs12361092; rs35632190; rs35691462; rs4646819; rs7483773; rs12288316; rs2447598; rs35605762; rs36154763; rs1131725; rs12272679; rs3928535; rs4930475; rs5019164; rs2447593; rs11227878; rs4646827; rs2126716; rs12285813; rs7943880; rs28819504; rs34264835; rs3741177; rs5792425; rs12807294; rs4244825; rs4646824; rs5792424; rs4646825; rs33990300; rs11826930; rs12574701; rs12294545; rs11824747; rs10736660; rs11828473; rs12272021; rs12288023; rs12363825; rs2054409; rs2447597; rs2509720; rs2514024; rs2514025; rs2885171; rs4930211; rs4930212; rs4930463; rs4930464; rs6591267; rs7108411

# Metabolic_Enzyme_10_General_References:
7484374; 8890755

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5530

# Metabolic_Enzyme_11_Name:
Aldehyde dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_11_Synonyms:
ALDH class 2; ALDHI; ALDH-E2

# Metabolic_Enzyme_11_Gene_Name:
ALDH2

# Metabolic_Enzyme_11_Protein_Sequence:
>Aldehyde dehydrogenase, mitochondrial precursor
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS

# Metabolic_Enzyme_11_Number_of_Residues:
517

# Metabolic_Enzyme_11_Molecular_Weight:
56382

# Metabolic_Enzyme_11_Theoretical_pI:
7.05

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_11_Specific_Function:
An aldehyde + NAD(+) + H(2)O = an acid + NADH

# Metabolic_Enzyme_11_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_11_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_11_Signals:
1-24

# Metabolic_Enzyme_11_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_11_GenBank_ID_Protein:
28606

# Metabolic_Enzyme_11_SwissProt_ID:
ALDH2_HUMAN (P05091)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
ALDH2

# Metabolic_Enzyme_11_Geneatlas_id:
ALDH2

# Metabolic_Enzyme_11_hgnc_id:
HGNC:404

# Metabolic_Enzyme_11_PDB_ID:
1OF7

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_11_Gene_Sequence:
>1551 bp
ATGTTGCGCGCTGCCGCCGCTCGGGCCCCGCCTGGCCGCCGCCTCTTGTCAGCCGCCGCC
ACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTTCATA
AACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACT
GGAGAGGTCATCTGTCAGGTAGCTGAAGGGGACAAGGAAGATGTGGACAAGGCACGTGAA
GGCCGCCCGGGCGCCTTCCAGCTGGGCTCACCTTGGCGCCGCATGGACGCATCACACAGC
GGCCGGCTGCTGAACCGCCTGGCCGATCTGATCGAGCGGGACCGGACCTACCTGGCGGCC
TTGGAGACCCTGGACAATGGCAAGCCCTATGTCATCTCCTACCTGGTGGATTTGGACATG
GTCCTCAAATGTCTCCGGTATTATGCCGGCTGGGCTGATAAGTACCACGGGAAAACCATC
CCCATTGACGGAGACTTCTTCAGCTACACACGCCATGAACCTGTGGGGGTGTGCGGGCAG
ATCATTCCGTGGAATTTCCCGCTCCTGATGCAAGCATGGAAGCTGGGCCCAGCCTTGGCA
ACTGGAAACGTGGTTGTGATGAAGGTAGCTGAGCAGACACCCCTCACCGCCCTCTATGTG
GCCAACCTGATCAAGGAGGCTGGCTTTCCCCCTGGTGTGGTCAACATTGTGCCTGGATTT
GGCCCCACGGCTGGGGCCGCCATTGCCTCCCATGAGGATGTGGACAAAGTGGCATTCACA
GGCTCCACTGAGATTGGCCGCGTAATCCAGGTTGCTGCTGGGAGCAGCAACCTCAAGAGA
GTGACCTTGGAGCTGGGGGGGAAGAGCCCCAACATCATCATGTCAGATGCCGATATGGAT
TGGGCCGTGGAACAGGCCCACTTCGCCCTGTTCTTCAACCAGGGCCAGTGCTGCTGTGCC
GGCTCCCGGACCTTCGTGCAGGAGGACATCTATGATGAGTTTGTGGTGCGGAGCGTTGCC
CGGGCCAAGTCTCGGGTGGTCGGGAACCCCTTTGATAGCAAGACCGAGCAGGGGCCGCAG
GTGGATGAAACTCAGTTTAAGAAGATCCTCGGCTACATCAACACGGGGAAGCAAGAGGGG
GCGAAGCTGCTGTGTGGTGGGGGCATTGCTGCTGACCGTGGTTACTTCATCCAGCCCACT
GTGTTTGGAGATGTGCAGGATGGCATGACCATCGCCAAGGAGGAGATCTTCGGGCCAGTG
ATGCAGATCCTGAAGTTCAAGACCATAGAGGAGGTTGTTGGGAGAGCCAACAATTCCACG
TACGGGCTGGCCGCAGCTGTCTTCACAAAGGATTTGGACAAGGCCAATTACCTGTCCCAG
GCCCTCCAGGCGGGCACTGTGTGGGTCAACTGCTATGATGTGTTTGGAGCCCAGTCACCC
TTTGGTGGCTACAAGATGTCGGGGAGTGGCCGGGAGTTGGGCGAGTACGGGCTGCAGGCA
TACACTGAAGTGAAAACTGTCACAGTCAAAGTGCCTCAGAAGAACTCATAA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
X05409

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_11_Locus:
12q24.2

# Metabolic_Enzyme_11_SNPs:
rs671; rs1062136; rs6490301; rs886205; rs2238151; rs968529; rs7296651; rs441; rs4767939; rs10744777; rs4646778; rs4767944; rs10849970; rs2158029; rs4646776; rs7312055; rs7311852; rs2238152; rs4646777; rs2283354; rs10774637; rs4648328; rs10774638; rs11609628; rs11066028; rs4646779; rs16941669; rs440; rs7397491; rs11834780; rs16941667; rs4646775; rs11066029; rs35154896; rs11066024; rs2106696; rs11613231; rs2158028; rs4767035; rs13306166; rs34083959; rs7136890; rs13306164; rs1064933; rs34477327; rs34884061; rs28633753; rs11442381; rs11615695; rs11066023; rs35511855; rs35781311; rs13306163; rs7397456; rs35050853; rs35642129; rs12312867; rs12829533; rs11407827; rs34480430; rs12314397; rs35264878; rs12813835; rs12322000; rs34896918; rs35650885; rs7970477; rs11066025; rs13306167; rs11066027; rs12301347; rs11614684; rs35700215; rs35746295; rs34587287; rs13306165; rs35786282; rs11066022; rs7397469; rs11066030; rs10450717; rs35693865; rs11503169; rs35546929; rs33973376; rs34497874; rs12830829; rs35061167; rs11609093; rs36073646; rs34108639; rs12824249; rs11610258; rs35147079; rs11613713; rs11066026; rs7486832; rs12099590; rs3832868; rs34300515; rs35212101; rs7398472; rs35239056; rs35752199; rs5800933; rs11613351; rs5023470; rs34587619; rs4646781; rs4646780; rs11304348; rs12305979; rs4646782; rs10849969; rs10849971; rs11066032; rs14630; rs2339839; rs2339840; rs7133964; rs737280; rs739580; rs7974339; rs7978737; rs9971942

# Metabolic_Enzyme_11_General_References:
3582651; 3562250; 2838413; 4065146; 2987944; 4015823; 3610592; 3653404; 6582480; 8561277; 10631996

# Metabolic_Enzyme_11_References:
15983043; 10235287; 11410717

# Metabolic_Enzyme_12_ID:
6060

# Metabolic_Enzyme_12_Name:
Alcohol dehydrogenase class 3

# Metabolic_Enzyme_12_Synonyms:
Alcohol dehydrogenase class III; Alcohol dehydrogenase class chi chain; S-; hydroxymethylglutathione dehydrogenase; Glutathione- dependent formaldehyde dehydrogenase; FDH

# Metabolic_Enzyme_12_Gene_Name:
ADH5

# Metabolic_Enzyme_12_Protein_Sequence:
>Alcohol dehydrogenase class 3
MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGC
FPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGK
GLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGY
GAAVNTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATEC
INPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEE
IATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFE
LMHSGKSIRTVVKI

# Metabolic_Enzyme_12_Number_of_Residues:
374

# Metabolic_Enzyme_12_Molecular_Weight:
39725

# Metabolic_Enzyme_12_Theoretical_pI:
7.54

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_12_Specific_Function:
Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione

# Metabolic_Enzyme_12_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_12_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_12_Signals:
None

# Metabolic_Enzyme_12_Transmembrane_Regions:
None

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 1.1.1.1;EC 1.1.1.284

# Metabolic_Enzyme_12_GenBank_ID_Protein:
178134

# Metabolic_Enzyme_12_SwissProt_ID:
ADHX_HUMAN (P11766)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
ADH5

# Metabolic_Enzyme_12_Geneatlas_id:
ADH5

# Metabolic_Enzyme_12_hgnc_id:
HGNC:253

# Metabolic_Enzyme_12_PDB_ID:
1MC5

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_12_Gene_Sequence:
>1125 bp
ATGGCGAACGAGGTTATCAAGTGCAAGGCTGCAGTTGCTTGGGAGGCTGGAAAGCCTCTC
TCCATAGAGGAGATAGAGGTGGCACCCCCAAAGGCTCATGAAGTTCGAATCAAGATCATT
GCCACTGCGGTTTGCCACACCGATGCCTATACCCTGAGTGGAGCTGATCCTGAGGGTTGT
TTTCCAGTGATCTTGGGACATGAAGGTGCTGGAATTGTGGAAAGTGTTGGTGAGGGAGTT
ACTAAGCTGAAGGCGGGTGACACTGTCATCCCACTTTACATCCCACAGTGTGGAGAATGC
AAATTTTGTCTAAATCCTAAAACTAACCTTTGCCAGAAGATAAGAGTCACTCAAGGGAAA
GGATTAATGCCAGATGGTACCAGCAGATTTACTTGCAAAGGAAAGACAATTTTGCATTAC
ATGGGAACCAGCACATTTTCTGAATACACAGTTGTGGCTGATATCTCTGTTGCTAAAATA
GATCCTTTAGCACCTTTGGATAAAGTCTGCCTTCTAGGTTGTGGCATTTCAACCGGTTAT
GGTGCTGCTGTGAACACTGCCAAGTTGGAGCCTGGCTCTGTTTGTGCCGTCTTTGGTCTG
GGAGGAGTCGGATTGGCAGTTATCATGGGCTGTAAAGTGGCTGGTGCTTCCCGGATCATT
GGTGTGGACATCAATAAAGATAAATTTGCAAGGGCCAAAGAGTTTGGAGCCACTGAATGT
ATTAACCCTCAGGATTTTAGTAAACCCATCCAGGAAGTGCTCATTGAGATGACCGATGGA
GGAGTGGACTATTCCTTTGAATGTATTGGTAATGTGAAGGTCATGAGAGCAGCACTTGAG
GCATGTCACAAGGGCTGGGGCGTCAGCGTCGTGGTTGGAGTAGCTGCTTCAGGTGAAGAA
ATTGCCACTCGTCCATTCCAGCTGGTAACAGGTCGCACATGGAAAGGCACTGCCTTTGGA
GGATGGAAGAGTGTAGAAAGTGTCCCAAAGTTGGTGTCTGAATATATGTCCAAAAAGATA
AAAGTTGATGAATTTGTGACTCACAATCTGTCTTTTGATGAAATCAACAAAGCCTTTGAA
CTGATGCATTCTGGAAAGAGCATTCGAACTGTTGTAAAGATTTAA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
M30471

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_12_Locus:
4q21-q25

# Metabolic_Enzyme_12_SNPs:
rs16996593; rs28730623; rs28730643; rs7669660; rs1803037; rs13832; rs11568816; rs6827292; rs12106; rs11547772; rs28730650; rs1061187; rs28730645; rs28730646; rs17028487; rs12697; rs28730649; rs1154410; rs7683802; rs896992; rs1154411; rs1154405; rs6846829; rs7683704; rs1154401; rs1154414; rs17028505; rs17028500; rs7658279; rs4699701; rs4699700; rs7688859; rs6852848; rs7658127; rs7658118; rs7666867; rs3018048; rs7688835; rs7688531; rs13109048; rs7688686; rs4699699; rs1154412; rs17595424; rs28730592; rs28730605; rs28894371; rs1154415; rs28730639; rs13145727; rs28985868; rs28730576; rs28730607; rs28730581; rs28730569; rs28730624; rs1154404; rs28730641; rs28730597; rs28730601; rs28730578; rs28730590; rs28730575; rs1154409; rs1154402; rs13118409; rs28730612; rs29001350; rs28730632; rs28730571; rs29001346; rs28730603; rs28730594; rs29001583; rs28730596; rs29001348; rs28730582; rs28730620; rs28730619; rs28730637; rs13127586; rs28730608; rs28730568; rs28730640; rs28894370; rs28730600; rs28730630; rs13146416; rs28730644; rs28730625; rs28730617; rs1154416; rs29001345; rs28730610; rs28730584; rs28730602; rs9799556; rs13125919; rs28730636; rs28730587; rs28730621; rs29001347; rs28730573; rs28730611; rs28730593; rs28730595; rs28730627; rs29001351; rs35123946; rs2866033; rs28730613; rs28730629; rs1154403; rs13119035; rs28730589; rs11934304; rs29001349; rs28730631; rs28730591; rs29001631; rs28730604; rs28730570; rs7684735; rs7679102; rs1154400; rs7684986; rs17216887; rs7662987; rs7667261; rs2602899; rs29001338; rs29001341; rs28730655; rs29001336; rs1230158; rs13132688; rs29001339; rs17028482; rs2851301; rs28987121; rs29001340; rs1050636; rs1050637; rs28730628; rs28730652; rs28730653; rs28730648; rs29001343; rs1803038; rs28730647; rs28730651; rs28730583; rs28730599; rs33990814; rs34370152; rs1154406; rs34443372; rs28730606; rs28730616; rs28730586; rs34609488; rs34912906; rs11317364; rs28730585; rs35796474; rs28730618; rs28730634; rs28730626; rs28730572; rs28894372; rs1154413; rs5860558; rs34470866; rs28730622; rs28730635; rs29001344; rs28730598; rs35169500; rs28894368; rs6148593; rs34594585; rs29001542; rs28730588; rs28730609; rs28730577; rs28730633; rs28730615; rs28730580; rs29001570; rs3805321; rs33981706; rs1154407; rs1235433; rs28730574; rs34763643; rs36160699; rs34146172; rs3792680; rs10618658; rs28730638; rs35904284; rs13133011; rs34452464; rs1154408; rs33972516; rs28730656; rs1048578; rs29001342; rs10582873; rs3974877; rs28730657; rs36093781; rs1048577; rs5860559; rs10560641; rs11455235; rs10616090; rs35101663; rs35815329; rs11553737; rs29001335; rs28730658; rs11292055; rs34834932; rs2187482; rs10587720; rs34985976; rs1130076; rs34439422; rs28730654; rs29001337; rs10006953; rs1230154; rs1230155; rs1230157; rs1230164; rs1230165; rs1238741; rs1311615; rs1311616; rs1311617; rs1311621; rs13120000; rs1312200; rs1473371; rs15193; rs17028473; rs17595102; rs17595186; rs2602836; rs2851286; rs28730614; rs2924584; rs7664906; rs7667424; rs7681427; rs7687322

# Metabolic_Enzyme_12_General_References:
2818582; 2679557; 1446828; 3365377; 8494891; 8460164; 9018047

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5758

# Metabolic_Enzyme_13_Name:
Alcohol dehydrogenase 4

# Metabolic_Enzyme_13_Synonyms:
Alcohol dehydrogenase class II pi chain

# Metabolic_Enzyme_13_Gene_Name:
ADH4

# Metabolic_Enzyme_13_Protein_Sequence:
>Alcohol dehydrogenase 4
MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEG
LAFPVIVGHE
AAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNL
KSPASDQQLMEDKTSRFTCKG
KPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLL
GCGFSTGYGAAINNAKVTPGSTCAVFGLGGVG
LSAVMGCKAAGASRIIGIDINSEKFVK
AKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSET
MKAALDCTTAGWGSCT
FIGVAAGSKGLTVFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDA
LVTHT
LPFDKISEAFDLMNQGKSIRTILIF

# Metabolic_Enzyme_13_Number_of_Residues:
380

# Metabolic_Enzyme_13_Molecular_Weight:
40222

# Metabolic_Enzyme_13_Theoretical_pI:
8.01

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_13_Specific_Function:
An alcohol + NAD(+) = an aldehyde or ketone + NADH

# Metabolic_Enzyme_13_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_13_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
None

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_13_GenBank_ID_Protein:
178121

# Metabolic_Enzyme_13_SwissProt_ID:
ADH4_HUMAN (P08319)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
ADH4

# Metabolic_Enzyme_13_Geneatlas_id:
ADH4

# Metabolic_Enzyme_13_hgnc_id:
HGNC:252

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_13_Gene_Sequence:
>1179 bp

ATGGGCACCAAGGGCAAAGTTATTAAATGCAAAGCAGCCATCGCCTGGGAAGCAGGCAA
GCCCCTTTGCA
TTGAAGAGGTTGAAGTAGCTCCCCCCAAGGCTCATGAAGTTCGCATTC
AGATCATTGCTACCTCCCTGTG
CCATACTGATGCCAGTGTTATCGATTCTAAATTTGAG
GGCCTAGCTTTCCCAGTGATCGTTGGCCATGAG
GCTGCAGGTATTGTGGAAAGTATTGG
GCCAGGAGTGACCAACGTCAAACCAGGTGACAAAGTAATTCCAC
TTTATGCACCTCTAT
GTAGAAAATGCAAGTTTTGTCTGAGTCCACTCACAAATTTGTGTGGGAAAATCAG
TAAT
CTCAAAAGTCCTGCTAGTGATCAACAACTAATGGAAGACAAAACCAGCAGGTTTACCTGC
AAAGGA
AAACCAGTTTACCATTTCTTTGGAACCAGTACATTCTCTCAGTACACTGTGGT
GTCAGATATCAATCTTG
CCAAAATAGATGATGATGCAAATTTAGAGAGAGTTTGTCTGC
TTGGATGTGGGTTTTCAACTGGCTATGG
GGCTGCAATCAACAATGCCAAGGTCACCCCT
GGTTCGACTTGTGCTGTCTTTGGCCTAGGAGGTGTGGGT
CTTTCTGCTGTAATGGGTTG
TAAAGCAGCAGGAGCTTCCAGAATCATAGGTATTGACATCAACAGTGAGA
AGTTTGTGA
AGGCTAAAGCCCTGGGAGCCACTGACTGCCTCAATCCTAGAGACTTACATAAACCGATCC
A
GGAAGTTATCATTGAATTGACCAAGGGAGGTGTGGATTTTGCCCTTGACTGTGCAGGT
GGATCTGAAACC
ATGAAAGCAGCCCTGGACTGTACAACCGCAGGCTGGGGATCATGTAC
TTTCATTGGAGTAGCTGCTGGTA
GCAAAGGATTGACTATTTTTCCAGAGGAGCTAATAA
TCGGCCGTACTATAAATGGAACATTCTTTGGTGG
TTGGAAAAGTGTAGATTCTATCCCA
AAGCTGGTCACTGACTATAAGAATAAGAAATTCAATCTGGATGCA
TTGGTGACCCATAC
CCTGCCTTTTGACAAAATCAGTGAGGCATTTGACCTAATGAACCAAGGAAAAAGCG
TCC
GAACAATCCTCATCTTTGGAAGATGCCAGGAGCAATTCAGAATACTATCTGATTGA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
M15943

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_13_Locus:
4q21-q24|4q22

# Metabolic_Enzyme_13_SNPs:
rs1126671; rs1126673; rs1126672; rs1126670; rs2032349; rs1042364; rs1042365; rs10097; rs1139490; rs4148886; rs7672728; rs7670060; rs6532798; rs2032348; rs6532799; rs2602895; rs7670241; rs7694646; rs13110764; rs2851247; rs7694844; rs4699714; rs17217949; rs6813415; rs10017466; rs13108999; rs7689753; rs6532797; rs6831352; rs2602894; rs28987095; rs17817868; rs17817359; rs3805322; rs7670638; rs9307234; rs7669636; rs7692974; rs17817958; rs6820625; rs13143133; rs2851248; rs10009145; rs17218162; rs13133647; rs17218239; rs17218602; rs1984360; rs6837685; rs17218003; rs13110176; rs2851246; rs17218141; rs6855482; rs29001203; rs4699713; rs17218560; rs13133633; rs17218108; rs6822348; rs17218073; rs4699712; rs10026860; rs6848050; rs17218288; rs13138294; rs6848576; rs4699710; rs6836440; rs13148577; rs4148890; rs28987097; rs29001202; rs29001236; rs29001218; rs29001221; rs13140423; rs28987090; rs28987088; rs13132999; rs34936974; rs4502688; rs29001175; rs1540054; rs29001209; rs29001192; rs29001223; rs29001216; rs7691700; rs29001214; rs5860563; rs29001194; rs29001222; rs29001188; rs29001208; rs28987100; rs6840413; rs29001234; rs29001229; rs5860565; rs28987102; rs13112924; rs29001227; rs2602897; rs3919370; rs4148887; rs13132776; rs29001232; rs29001190; rs28987092; rs29001211; rs6532800; rs29001237; rs13106879; rs28987089; rs13113166; rs13133214; rs29001224; rs28987098; rs4699715; rs13125262; rs13112733; rs29001235; rs6840888; rs29001199; rs13133140; rs29001183; rs29001177; rs29001217; rs29001170; rs6841113; rs29001215; rs28987101; rs1573495; rs29001195; rs13129488; rs29001212; rs13112176; rs29001207; rs29001196; rs1984361; rs13102874; rs29001231; rs1984365; rs2213035; rs29001210; rs13108745; rs4148888; rs10712996; rs2602896; rs13107558; rs29001201; rs2602891; rs4148884; rs2226896; rs3762894; rs4148883; rs1800761; rs2851253; rs4140388; rs4699716; rs6858148; rs2924583; rs1800760; rs2851249; rs1800759; rs2851251; rs2213034; rs29001169; rs2851252; rs2851254; rs2602893; rs2602890; rs4699717; rs35229514; rs29001219; rs1139492; rs35490064; rs1139491; rs1139489; rs29001238; rs35073321; rs35760460; rs29001182; rs35767213; rs33933720; rs29001205; rs34876213; rs35652689; rs34071486; rs35019093; rs13127582; rs29001198; rs4699711; rs29001181; rs29001176; rs29001171; rs33927405; rs35882815; rs28987094; rs29001213; rs29001186; rs29001230; rs29001197; rs29001178; rs35786878; rs36034266; rs28987099; rs29001200; rs34805407; rs28816225; rs34338603; rs29001225; rs34360292; rs29001172; rs11728281; rs34069499; rs11732799; rs35062722; rs35774359; rs34118841; rs29001220; rs29001204; rs29001174; rs29001233; rs41275695; rs3049429; rs29001180; rs35385089; rs10711227; rs4148891; rs33955894; rs28987096; rs29001189; rs29001193; rs35108469; rs13127153; rs35784540; rs29001228; rs28987093; rs10014222; rs5860564; rs29001226; rs29001179; rs35205530; rs34295744; rs35406734; rs33977891; rs11724440; rs28987091; rs2156732; rs33958017; rs29001173; rs35518660; rs35246304; rs29001184; rs29001191; rs35662508; rs5860566; rs11317458; rs35988291; rs29001650; rs28973169; rs35283873; rs28542574; rs3049432; rs34851571; rs10648918; rs28987087; rs2851250; rs34634551; rs3049427; rs33970666; rs10678943; rs35146617; rs10032099; rs12649136; rs17028615; rs1984362; rs1984364; rs2156731; rs2602865; rs2602866; rs2602874; rs2602875; rs2602876; rs2602877; rs2602878; rs2602883; rs2602884; rs2602885; rs2602886; rs2851255; rs2851256; rs2851257; rs3828541; rs4235435; rs4235436; rs4699718; rs4699720; rs6532795; rs6532796; rs7434491; rs7698301

# Metabolic_Enzyme_13_General_References:
3036213; 1889753

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
6324

# Metabolic_Enzyme_14_Name:
Cytochrome P450 2C9

# Metabolic_Enzyme_14_Synonyms:
(R-limonene 6-monooxygenase; (S-limonene 6-monooxygenase; (S- limonene 7-monooxygenase; CYPIIC9; P450 PB-1; P450 MP-4/MP-8; S- mephenytoin 4-hydroxylase; P-450MP

# Metabolic_Enzyme_14_Gene_Name:
CYP2C9

# Metabolic_Enzyme_14_Protein_Sequence:
>Cytochrome P450 2C9
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
PFYQLCFIPV

# Metabolic_Enzyme_14_Number_of_Residues:
490

# Metabolic_Enzyme_14_Molecular_Weight:
55629

# Metabolic_Enzyme_14_Theoretical_pI:
7.99

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_14_Specific_Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S- warfarin, diclofenac, phenytoin, tolbutamide and losartan

# Metabolic_Enzyme_14_Pathway:
map00902  Monoterpenoid biosynthesis;
 map00903  Limonene and pinene degradation;
GENES       HSA: 1559(CYP2C9)

# Metabolic_Enzyme_14_Reaction:
(+)-(R)-limonene + NADPH + H+ + O2 = (+)-trans-carveol + NADP+ + H2O

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_14_Signals:
1-25

# Metabolic_Enzyme_14_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 1.14.13.80;EC 1.14.13.

# Metabolic_Enzyme_14_GenBank_ID_Protein:
181366

# Metabolic_Enzyme_14_SwissProt_ID:
CP2C9_HUMAN (P11712)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
CYP2C9

# Metabolic_Enzyme_14_Geneatlas_id:
CYP2C9

# Metabolic_Enzyme_14_hgnc_id:
HGNC:2623

# Metabolic_Enzyme_14_PDB_ID:
1R9O

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein

# Metabolic_Enzyme_14_Gene_Sequence:
>1152 bp
AGAGGATTTGGAATTGTTTTCAGCAATGGAAAGAAATGGAAGGAGATCCGGCGTTTCTCC
CTCATGACGCTGCGGAATTTTGGGATGGGGAAGAGGAGCATTGAGGACCGTGTTCAAGAG
GAAGCCCGCTGCCTTGTGGAGGAGTTGAGAAAAACCAAGGCCTCACCCTGTGATCCCACT
TTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCCATTATTTTCCATAAACGTTTT
GATTATAAAGATCAGCAATTTCTTAACTTAATGGAAAAGTTGAATGAAAACATCAAGATT
TTGAGCAGCCCCTGGATCCAGATCTGCAATAATTTTTCTCCTATCATTGATTACTTCCCG
GGAACTCACAACAAATTACTTAAAAACGTTGCTTTTATGAAAAGTTATATTTTGGAAAAA
GTAAAAGAACACCAAGAATCAATGGACATGAACAACCCTCAGGACTTTATTGATTGCTTC
CTGATGAAAATGGAGAAGGAAAAGCACAACCAACCATCAGAATTTACTATTGAAAGCTTG
GAAAACACTGCAGTTGACTTGTTTGGAGCTGGGACAGAGACGACAAGCACAACCCTGAGA
TATGCTCTCCTTCTCCTGCTGAAGCACCCAGAGGTCACAGCTAAAGTCCAGGAAGAGATT
GAACGTGTGATTGGCAGAAACCGGAGCCCCTGCATGCAAGACAGGAGCCACATGCCCTAC
ACAGATGCTGTGGTGCACGAGGTCCAGAGATGCATTGACCTTCTCCCCACCAGCCTGCCC
CATGCAGTGACCTGTGACATTAAATTCAGAAACTATCTCATTCCCAAGGGCACAACCATA
TTAATTTCCCTGACTTCTGTGCTACATGACAACAAAGAATTTCCCAACCCAGAGATGTTT
GACCCTCATCACTTTCTGGATGAAGGTGGCAATTTTAAGAAAAGTAAATACTTCATGCCT
TTCTCAGCAGGAAAACGGATTTGTGTGGGAGAAGCCCTGGCCGGCATGGAGCTGTTTTTA
TTCCTGACCTCCATTTTACAGAACTTTAACCTGAAATCTCTGGTTGACCCAAAGAACCTT
GACACCACTCCAGTTGTCAATGGATTTGCCTCTGTGCCGCCCTTCTACCAGCTGTGCTTC
ATTCCTGTCTGA

# Metabolic_Enzyme_14_GenBank_ID_Gene:
M21940

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_14_Locus:
10q24

# Metabolic_Enzyme_14_SNPs:
rs2256871; rs1799853; rs7900194; rs1057910; rs1057909; rs12414460; rs1057911; rs2017319; rs5031019; rs9332241; rs9332242; rs9332244; rs9332240; rs1934969; rs1934963; rs2253635; rs1856908; rs2298037; rs2475376; rs1934967; rs12772884; rs1200313; rs1934968; rs9332172; rs9332220; rs4917639; rs9332127; rs9332140; rs9332232; rs9332113; rs9332117; rs7074012; rs10509680; rs9332134; rs9332165; rs9332177; rs1934966; rs1934962; rs17443251; rs9332216; rs9332209; rs9332169; rs10882507; rs9332222; rs1934959; rs9332116; rs2153629; rs4918766; rs12772675; rs9332132; rs4086116; rs9332234; rs1341161; rs10509679; rs9332168; rs7897079; rs2153628; rs4351748; rs2901824; rs9332208; rs9332214; rs9332119; rs9332230; rs12572351; rs4918795; rs9332174; rs9332121; rs9332219; rs9325473; rs9332167; rs9332118; rs9332104; rs9332120; rs9332197; rs2487502; rs9332226; rs9332155; rs9332228; rs9332212; rs9332141; rs9731221; rs9332193; rs9332238; rs9332137; rs9332157; rs17110288; rs2096069; rs9332194; rs9332105; rs7476934; rs7475054; rs9332166; rs3980257; rs7089580; rs9332196; rs2860968; rs9332126; rs6583964; rs12569850; rs7917731; rs7073165; rs9332128; rs12573036; rs9332149; rs9332227; rs3980254; rs9332184; rs7072260; rs12572373; rs9332233; rs9332199; rs9332223; rs9332236; rs2860906; rs7085035; rs9332217; rs9332215; rs9332147; rs9332183; rs9332138; rs9332176; rs9332175; rs1934960; rs12416142; rs9332129; rs9332218; rs9332107; rs12415137; rs9332205; rs11599435; rs9332124; rs9332198; rs9332136; rs9332224; rs1934964; rs17847029; rs9332139; rs9332192; rs9332153; rs2487501; rs9332110; rs9332237; rs9332201; rs12245729; rs9332142; rs9332235; rs12262254; rs9332163; rs9332108; rs9332187; rs9332151; rs9332179; rs7083767; rs9332211; rs9332160; rs9332146; rs9332181; rs12572588; rs1934965; rs2860905; rs9332188; rs4918758; rs9332093; rs4917636; rs9332245; rs9332099; rs9332100; rs9332094; rs9332101; rs9332092; rs9332096; rs9332102; rs9332098; rs9332130; rs17847037; rs9332239; rs28371685; rs9332131; rs5030781; rs28371686; rs28371687; rs28371673; rs17847036; rs1135654; rs9332173; rs17847032; rs12269642; rs28969379; rs9332243; rs9332221; rs28371691; rs12767175; rs2265609; rs9332112; rs9332122; rs9332203; rs28371677; rs28371679; rs9332162; rs9332186; rs34071691; rs9332109; rs35144931; rs41291560; rs34977198; rs9332145; rs28371688; rs35158548; rs12264119; rs2860969; rs2793285; rs2264932; rs28371681; rs9332206; rs12572071; rs1200312; rs9332182; rs2487499; rs35775635; rs35626865; rs9332202; rs28371678; rs9332229; rs9332154; rs2487500; rs2265608; rs36056939; rs12262620; rs9332111; rs4344423; rs34532201; rs9332213; rs11188120; rs4917641; rs17847041; rs2994704; rs35687798; rs9332115; rs3980250; rs9332123; rs2793284; rs1200314; rs12252334; rs28371682; rs9332150; rs12781007; rs28371689; rs28969378; rs10637048; rs9332143; rs7084024; rs11188121; rs34911663; rs9332164; rs2994703; rs7068328; rs36002977; rs35617077; rs17847040; rs12785201; rs2860970; rs12264083; rs35803517; rs9332185; rs9332159; rs28371690; rs12780709; rs12769684; rs9332210; rs35601426; rs34483281; rs3980251; rs11456510; rs9332171; rs34421425; rs7089813; rs34260936; rs9332106; rs7893727; rs12247980; rs2265610; rs17847035; rs28371675; rs3980258; rs9332148; rs9332180; rs9332161; rs2984310; rs35126593; rs9332191; rs3961966; rs12780688; rs12783288; rs28371683; rs1200315; rs3058948; rs7917838; rs9332170; rs9332114; rs7897401; rs1578438; rs28371680; rs9332204; rs34231123; rs9332207; rs9332178; rs9332190; rs3980256; rs9332231; rs35370382; rs35571078; rs3980259; rs28371676; rs33968005; rs34900301; rs35406621; rs9332200; rs28371684; rs9332225; rs9332125; rs35511771; rs12257938; rs9332195; rs9332152; rs3740503; rs9332095; rs36103485; rs9332103; rs9332097; rs11516923; rs12251688; rs12252207; rs12255458; rs12782374; rs1505; rs1934970; rs2475377

# Metabolic_Enzyme_14_General_References:
2827463; 3697070; 2963808; 3032244; 3196692; 1445376; 3079764; 3243766; 1857342; 8809086; 8215449; 11950794; 12861225; 8946475; 9110362; 10739176; 11455026; 11926893

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
6064

# Metabolic_Enzyme_15_Name:
Alcohol dehydrogenase 1A

# Metabolic_Enzyme_15_Synonyms:
Alcohol dehydrogenase alpha subunit

# Metabolic_Enzyme_15_Gene_Name:
ADH1A

# Metabolic_Enzyme_15_Protein_Sequence:
>Alcohol dehydrogenase 1
AMSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAVGICGTDDHVVSGTMV
TPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLAIPQCGKCRICKNPESNYCLKNDVSN
PQGTLQDGTSRFTCRRKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFST
GYGSAVNVAKVTPGSTCAVFGLGGVGLSAIMGCKAAGAARIIAVDINKDKFAKAKELGAT
ECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDS
QNLSMNPMLLLTGRTWKGAILGGFKSKECVPKLVADFMAKKFSLDALITHVLPFEKINEG
FDLLHSGKSIRTILMF

# Metabolic_Enzyme_15_Number_of_Residues:
375

# Metabolic_Enzyme_15_Molecular_Weight:
39859

# Metabolic_Enzyme_15_Theoretical_pI:
8.02

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_15_Specific_Function:
An alcohol + NAD(+) = an aldehyde or ketone + NADH

# Metabolic_Enzyme_15_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_15_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_15_Signals:
None

# Metabolic_Enzyme_15_Transmembrane_Regions:
None

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_15_GenBank_ID_Protein:
178092

# Metabolic_Enzyme_15_SwissProt_ID:
ADH1A_HUMAN (P07327)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
ADH1A

# Metabolic_Enzyme_15_Geneatlas_id:
ADH1A

# Metabolic_Enzyme_15_hgnc_id:
HGNC:249

# Metabolic_Enzyme_15_PDB_ID:
1HSO

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_15_Gene_Sequence:
>1128 bp
ATGAGCACAGCAGGAAAAGTAATCAAATGCAAAGCAGCTGTGCTATGGGAGTTAAAGAAA
CCCTTTTCCATTGAGGAGGTGGAGGTTGCACCTCCTAAGGCCCATGAAGTTCGTATTAAG
ATGGTGGCTGTAGGAATCTGTGGCACAGATGACCACGTGGTTAGTGGTACCATGGTGACC
CCACTTCCTGTGATTTTAGGCCATGAGGCAGCCGGCATCGTGGAGAGTGTTGGAGAAGGG
GTGACTACAGTCAAACCAGGTGATAAAGTCATCCCACTCGCTATTCCTCAGTGTGGAAAA
TGCAGAATTTGTAAAAACCCGGAGAGCAACTACTGCTTGAAAAACGATGTAAGCAATCCT
CAGGGGACCCTGCAGGATGGCACCAGCAGGTTCACCTGCAGGAGGAAGCCCATCCACCAC
TTCCTTGGCATCAGCACCTTCTCACAGTACACAGTGGTGGATGAAAATGCAGTAGCCAAA
ATTGATGCAGCCTCGCCTCTAGAGAAAGTCTGTCTCATTGGCTGTGGATTTTCAACTGGT
TATGGGTCTGCAGTCAATGTTGCCAAGGTCACCCCAGGCTCTACCTGTGCTGTGTTTGGC
CTGGGAGGGGTCGGCCTATCTGCTATTATGGGCTGTAAAGCAGCTGGGGCAGCCAGAATC
ATTGCGGTGGACATCAACAAGGACAAATTTGCAAAGGCCAAAGAGTTGGGGGCCACTGAA
TGCATCAACCCTCAAGACTACAAGAAACCCATCCAGGAGGTGCTAAAGGAAATGACTGAT
GGAGGTGTGGATTTTTCATTTGAAGTCATCGGTCGGCTTGACACCATGATGGCTTCCCTG
TTATGTTGTCATGAGGCATGTGGCACAAGTGTCATCGTAGGGGTACCTCCTGATTCCCAA
AACCTCTCAATGAACCCTATGCTGCTACTGACTGGACGTACCTGGAAGGGAGCTATTCTT
GGTGGCTTTAAAAGTAAAGAATGTGTCCCAAAACTTGTGGCTGATTTTATGGCTAAGAAG
TTTTCATTGGATGCATTAATAACCCATGTTTTACCTTTTGAAAAAATAAATGAAGGATTT
GACCTGCTTCACTCTGGGAAAAGTATCCGTACCATTCTGATGTTTTGA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
M12271

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_15_Locus:
4q21-q23

# Metabolic_Enzyme_15_SNPs:
rs6828526; rs2866151; rs1229970; rs12504321; rs28364312; rs6835771; rs3805325; rs1229969; rs931635; rs975833; rs1229977; rs3805324; rs13120422; rs2276332; rs3819197; rs1229967; rs4147532; rs28364333; rs1229968; rs28364323; rs33991678; rs28364307; rs28364328; rs1229976; rs28364304; rs28364324; rs28364334; rs28364322; rs28364338; rs28364294; rs28364311; rs28364305; rs28364298; rs28364332; rs28364335; rs28364319; rs28364321; rs28364292; rs28364313; rs28364329; rs28364336; rs28364296; rs4147531; rs12512110; rs1229966; rs13120304; rs7684674; rs17584149; rs28364286; rs6835371; rs28364283; rs28364342; rs13134764; rs28364341; rs28364340; rs28364325; rs28364337; rs28364315; rs10690902; rs28364293; rs34073783; rs4147533; rs28364297; rs28364301; rs28364306; rs28364314; rs35568460; rs28521649; rs28745868; rs28364330; rs13126850; rs28364300; rs28364317; rs28364339; rs28364327; rs12645219; rs13116877; rs1229971; rs28364309; rs28364331; rs2051429; rs12508502; rs12504365; rs28364295; rs28364316; rs35613639; rs34235527; rs28364326; rs12512053; rs28364299; rs28364308; rs28364303; rs28364318; rs35573104; rs33992258; rs5860574; rs28364320; rs34362837; rs6854980; rs28364289; rs28364285; rs35984131; rs34231176; rs5860573; rs35354633; rs11461839; rs28364287; rs28364282; rs28364290; rs2173198; rs28364288; rs28364343; rs28364284; rs28364291; rs1230024; rs12504387; rs13103321; rs13117371; rs13123099; rs13145277; rs17028765; rs17028770; rs2051427; rs6811453; rs6812015; rs6837311; rs904092

# Metabolic_Enzyme_15_General_References:
3013304; 2935875; 2920825; 2347582

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
6065

# Metabolic_Enzyme_16_Name:
Alcohol dehydrogenase 6

# Metabolic_Enzyme_16_Synonyms:
Not Available

# Metabolic_Enzyme_16_Gene_Name:
ADH6

# Metabolic_Enzyme_16_Protein_Sequence:
>Alcohol dehydrogenase 6
MSTTGQVIRCKAAILWKPGAPFSIEEVEVAPPKAKEVRIKVVATGLCGTEMKVLGSKHLD
LLYPTILGHE
GAGIVESIGEGVSTVKPGDKVITLFLPQCGECTSCLNSEGNFCIQFKQS
KTQLMSDGTSRFTCKGKSIYH
FGNTSTFCEYTVIKEISVAKIDAVAPLEKVCLISCGFS
TGFGAAINTAKVTPGSTCAVFGLGGVGLSVVM
GCKAAGAARIIGVDVNKEKFKKAQELG
ATECLNPQDLKKPIQEVLFDMTDAGIDFCFEAIGNLDVLAAAL
ASCNESYGVCVVVGVL
PASVQLKISGQLFFSGRSLKGSVFGGWKSRQHIPKLVADYMAEKLNLDPLITHT
LNLDK
INEAVELMKTGKW

# Metabolic_Enzyme_16_Number_of_Residues:
368

# Metabolic_Enzyme_16_Molecular_Weight:
39073

# Metabolic_Enzyme_16_Theoretical_pI:
7.86

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_16_Specific_Function:
An alcohol + NAD(+) = an aldehyde or ketone + NADH

# Metabolic_Enzyme_16_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_16_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_16_Signals:
None

# Metabolic_Enzyme_16_Transmembrane_Regions:
None

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_16_GenBank_ID_Protein:
178146

# Metabolic_Enzyme_16_SwissProt_ID:
ADH6_HUMAN (P28332)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
ADH6

# Metabolic_Enzyme_16_Geneatlas_id:
ADH6

# Metabolic_Enzyme_16_hgnc_id:
HGNC:255

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_16_Gene_Sequence:
>1107 bp

ATGAGTACTACAGGCCAAGTCATCAGATGCAAAGCAGCCATACTCTGGAAGCCTGGTGC
ACCATTTTCTA
TTGAAGAGGTAGAAGTGGCCCCACCAAAGGCAAAGGAGGTTCGCATAA
AGGTTGTGGCCACCGGACTGTG
TGGTACAGAGATGAAAGTGTTGGGGAGTAAACACTTG
GACCTCTTGTATCCCACCATCTTGGGCCATGAA
GGGGCTGGAATCGTTGAGAGTATTGG
AGAAGGAGTAAGCACAGTGAAACCAGGTGACAAAGTTATCACAC
TCTTTCTGCCACAGT
GTGGAGAATGTACCTCTTGCCTGAATTCTGAGGGCAATTTTTGTATACAATTCAA
ACAG
TCAAAAACCCAACTGATGTCTGATGGTACCAGCAGGTTTACCTGCAAGGGAAAATCAATA
TATCAC
TTTGGTAATACCAGCACCTTCTGTGAATACACAGTGATAAAGGAAATCTCAGT
TGCCAAGATTGATGCAG
TCGCTCCTCTAGAGAAAGTATGCCTAATTAGCTGTGGCTTTT
CCACTGGGTTTGGTGCTGCAATCAATAC
TGCCAAGGTGACTCCAGGTTCTACCTGTGCT
GTGTTTGGCCTGGGAGGAGTCGGCTTGTCTGTTGTCATG
GGTTGTAAAGCAGCAGGAGC
AGCCAGGATCATTGGAGTGGATGTCAACAAGGAGAAATTTAAGAAGGCAC
AGGAATTGG
GTGCGACTGAGTGCCTCAACCCTCAGGACTTAAAGAAACCCATTCAAGAAGTTTTATTTG
A
TATGACAGATGCTGGTATAGACTTCTGCTTTGAGGCCATTGGAAATCTGGACGTTCTG
GCAGCTGCCCTC
GCCTCCTGCAATGAGAGCTATGGGGTCTGTGTGGTTGTTGGGGTGTT
GCCTGCCAGTGTTCAACTCAAAA
TCAGTGGCCAGTTGTTCTTCTCAGGACGTTCTTTGA
AGGGTTCTGTTTTTGGAGGCTGGAAGAGCAGACA
GCACATCCCTAAACTGGTTGCTGAT
TATATGGCAGAGAAGTTGAATCTAGATCCACTAATTACTCATACT
CTGAATCTTGATAA
AATCAATGAAGCAGTTGAATTAATGAAAACTGGAAAATGGTAA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
M84402

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_16_Locus:
4q23

# Metabolic_Enzyme_16_SNPs:
rs34582580; rs3857224; rs4147547; rs2156733; rs2187483; rs4147545; rs4699733; rs6833176; rs9307238; rs4147544; rs17219626; rs7692358; rs17219837; rs9995799; rs7661441; rs17028743; rs10030920; rs6820368; rs1893882; rs17028735; rs28891986; rs28720148; rs28720143; rs28720157; rs28720134; rs28720150; rs28720139; rs28720155; rs28891982; rs17028732; rs4699734; rs5860571; rs28891984; rs28720159; rs28720146; rs28720147; rs28891987; rs28720140; rs28720149; rs28891983; rs17028740; rs28720151; rs28891985; rs1893883; rs10008281; rs13104485; rs10002894; rs2866041; rs12507078; rs28720166; rs28720167; rs28720128; rs28720164; rs28720130; rs28720129; rs28720152; rs4699735; rs28720153; rs4147546; rs6843298; rs28720162; rs1893881; rs28720160; rs33918268; rs28720145; rs11097661; rs28720154; rs28720156; rs5860570; rs4147548; rs17028745; rs28720141; rs34347755; rs28720161; rs34008565; rs10026121; rs34584669; rs28720135; rs34587044; rs4283664; rs3049463; rs36016490; rs10025760; rs28720144; rs5860569; rs28720158; rs28720133; rs11097660; rs35632288; rs34273750; rs28720142; rs35482105; rs34686169; rs35230679; rs11305316; rs35171550; rs28720138; rs28720136; rs1130919; rs28720132; rs1130917; rs34932624; rs1130918; rs28720165; rs34713251; rs28720131; rs28720163; rs35371403; rs34274880; rs1130921; rs11733695; rs12510722; rs2000864; rs2051428; rs6532807; rs6814114; rs6828364; rs6830685

# Metabolic_Enzyme_16_General_References:
1881901

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5596

# Metabolic_Enzyme_17_Name:
Aldo-keto reductase family 1 member C3

# Metabolic_Enzyme_17_Synonyms:
Trans-1,2- dihydrobenzene-1,2-diol dehydrogenase; 3-alpha- hydroxysteroid dehydrogenase type 2; 3-alpha-HSD type 2; 3-alpha-HSD type II, brain; Prostaglandin F synthase; PGFS; Estradiol 17-beta-dehydrogenase; 17-beta-hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5; Chlordecone reductase homolog HAKRb; HA1753; Dihydrodiol dehydrogenase type I; Dihydrodiol dehydrogenase 3; DD3; DD-3

# Metabolic_Enzyme_17_Gene_Name:
AKR1C3

# Metabolic_Enzyme_17_Protein_Sequence:
>Aldoketo reductase family 1 member C3
MDSKQQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
RNLHYFNSDSFASHPNYPYSDEY

# Metabolic_Enzyme_17_Number_of_Residues:
323

# Metabolic_Enzyme_17_Molecular_Weight:
36845

# Metabolic_Enzyme_17_Theoretical_pI:
8.06

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Not Available

# Metabolic_Enzyme_17_Specific_Function:
Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9alpha,11beta- PGF2 to PGD2. Functions as a bi-directional 3alpha-, 17beta- and 20alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone

# Metabolic_Enzyme_17_Pathway:
map00590  Prostaglandin and leukotriene metabolism

# Metabolic_Enzyme_17_Reaction:
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_17_Signals:
None

# Metabolic_Enzyme_17_Transmembrane_Regions:
None

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 1.3.1.20;EC 1.1.1.213;

# Metabolic_Enzyme_17_GenBank_ID_Protein:
4261711

# Metabolic_Enzyme_17_SwissProt_ID:
AK1C3_HUMAN (P42330)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
AKR1C3

# Metabolic_Enzyme_17_Geneatlas_id:
AKR1C3

# Metabolic_Enzyme_17_hgnc_id:
HGNC:386

# Metabolic_Enzyme_17_PDB_ID:
1XF0

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_17_Gene_Sequence:
>972 bp
ATGGATTCCAAACAGCAGTGTGTAAAGCTAAATGATGGCCACTTCATGCCTGTATTGGGA
TTTGGCACCTATGCACCTCCAGAGGTTCCGAGAAGTAAAGCTTTGGAGGTCACAAAATTA
GCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCATTTATACAATAATGAGGAGCAG
GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTTGAGAGAGAAGACATATTC
TACACTTCAAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGTCCGACCAGCCTTGGAA
AACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCTCTATCTTATTCATTCTCCAATG
TCTCTAAAGCCAGGTGAGGAACTTTCACCAACAGATGAAAATGGAAAAGTAATATTTGAC
ATAGTGGATCTCTGTACCACCTGGGAGGCCATGGAGAAGTGTAAGGATGCAGGATTGGCC
AAGTCCATTGGGGTATCAAACTTCAACCGCAGGCAGCTGGAGATCATCCTCAACAAGCCA
GGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCGTATTTCAACCGGAGT
AAATTGCTAGATTTCTGCAAGTCGAAAGATATTGTTCTGGTTGCCTATAGTGCTCTGGGA
TCTCAACGAGACAAACGATGGGTGGACCCGAACTCCCCGGTCCTCTTGGAGGACCCAGTC
CTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAG
CTGCAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAAC
GTGCAGGTTTTTGAGTTCCAGTTGACTGCAGAGGACATGAAAGCCATAGATGGCCTAGAC
AGAAATCTCCACTATTTTAACAGTGATAGTTTTGCTAGCCACCCTAATTATCCATATTCA
GATGAATATTAA

# Metabolic_Enzyme_17_GenBank_ID_Gene:
S68288

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_17_Locus:
10p15-p14

# Metabolic_Enzyme_17_SNPs:
rs12529; rs1804062; rs35575889; rs34186955; rs35961894; rs12387; rs1937839; rs28943574; rs7741; rs3209896; rs1937840; rs2801883; rs2275928; rs2245191; rs1937843; rs2154309; rs9329316; rs11252951; rs4641368; rs4478887; rs7076063; rs4242785; rs10508294; rs4512728; rs10904418; rs9888062; rs2298305; rs2518049; rs4881400; rs7917546; rs2801882; rs17173403; rs7091485; rs2154307; rs10795245; rs11252945; rs11252941; rs33921818; rs17155732; rs1937841; rs11252942; rs33979906; rs11252943; rs12769666; rs12775701; rs9888075; rs10508293; rs11252944; rs2154306; rs10160019; rs3750566; rs11252950; rs10904416; rs12242350; rs11252939; rs35768949; rs12267712; rs35567055; rs34760938; rs34936429; rs36050091; rs4987101; rs17396032; rs11252940; rs7090349; rs4559587; rs35955223; rs12244591; rs11252946; rs4347280; rs34291069; rs36003741; rs12775913; rs17134355; rs34320249; rs7920141; rs36204597; rs2339; rs34140485; rs4584484; rs10904417; rs4584485; rs34304688; rs12775922; rs35983920; rs9329315; rs35047456; rs4264066; rs12782982; rs12244584; rs10904419; rs34335319; rs3763676; rs10904421; rs11818810; rs10904415; rs11252935; rs1937845; rs7894034; rs2518047; rs17134359; rs11252936; rs36000531; rs34516592; rs34722940; rs35483669; rs35531692; rs11252937; rs28942669; rs11551178; rs1131132; rs4987102; rs41306308; rs1804059; rs28943579; rs7342072; rs17849485; rs1131124; rs1804061; rs1804060; rs6581; rs28943581; rs28943582; rs35460332; rs35951787; rs35498365; rs34464507; rs3996506; rs11273607; rs34805426; rs35558480; rs34376012; rs12219397; rs1937844; rs4987103; rs12775924; rs34401009; rs35550189; rs11252947; rs7913166; rs35859199; rs34365063; rs35516441; rs7089963; rs2298304; rs41306310; rs35338655; rs34942947; rs34429432; rs12413055; rs34774984; rs11252948; rs35174293; rs10637298; rs5782801; rs28758366; rs7090071; rs34977292; rs10654845; rs35681139; rs10637297; rs11270349; rs35857003; rs11252938; rs3216070; rs35888676; rs34948891; rs34791059; rs5782800; rs11252949; rs34835891; rs35156069; rs11592217; rs34747896; rs28943578; rs34819103; rs11819187; rs5782802; rs34506108; rs34070010; rs35613411; rs35843850; rs28943577; rs36201177; rs35754932; rs1937846; rs35143522; rs28943576; rs35288974; rs10904422; rs10904423; rs10904428; rs11252931; rs11252932; rs11252934; rs11252955; rs11252960; rs11813521; rs12263243; rs12354530; rs12414038; rs17134288; rs1937847; rs1937848; rs1937849; rs1937905; rs1937906; rs2211624; rs2211625; rs2211630; rs2226260; rs34706100; rs4636560; rs4880708; rs4880709; rs4880710; rs7068685; rs7070041; rs7086771; rs7088288; rs7477623; rs7478099; rs7904863; rs7917079; rs7921327

# Metabolic_Enzyme_17_General_References:
8274401; 7650035; 7626489; 9415401; 10622721; 10557352; 10672042; 11165022; 7788527; 9927279

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5526

# Metabolic_Enzyme_18_Name:
4-trimethylaminobutyraldehyde dehydrogenase

# Metabolic_Enzyme_18_Synonyms:
TMABADH; Aldehyde dehydrogenase 9A1; Aldehyde dehydrogenase E3 isozyme; Gamma-aminobutyraldehyde dehydrogenase; R- aminobutyraldehyde dehydrogenase

# Metabolic_Enzyme_18_Gene_Name:
ALDH9A1

# Metabolic_Enzyme_18_Protein_Sequence:
>4trimethylaminobutyraldehyde dehydrogenase
MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA
AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY
AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK
PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI
MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI
LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY
VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA
AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL
KTVCVEMGDVESAF

# Metabolic_Enzyme_18_Number_of_Residues:
494

# Metabolic_Enzyme_18_Molecular_Weight:
53802

# Metabolic_Enzyme_18_Theoretical_pI:
5.61

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_18_Specific_Function:
Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction

# Metabolic_Enzyme_18_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_18_Reaction:
4-trimethylammoniobutanal + NAD+ = 4-trimethylammoniobutanoate + NADH + H+

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_18_Signals:
None

# Metabolic_Enzyme_18_Transmembrane_Regions:
None

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 1.2.1.47;EC 1.2.1.3;EC

# Metabolic_Enzyme_18_GenBank_ID_Protein:
1049219

# Metabolic_Enzyme_18_SwissProt_ID:
AL9A1_HUMAN (P49189)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
ALDH9A1

# Metabolic_Enzyme_18_Geneatlas_id:
ALDH9A1

# Metabolic_Enzyme_18_hgnc_id:
HGNC:412

# Metabolic_Enzyme_18_PDB_ID:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_18_Gene_Sequence:
>1482 bp
ATGAGCACTGGCACCTTCGTCGTGTCGCAGCCGCTCAATTACCGCGGCGGGGCCGCTGGA
GCCGGCGGACGCTCCGGTACCGAGAAAGCTTTCGAGCCAGCAACCGGCCGAGTGATAGCT
ACTTTCACATGTTCAGGAGAAAAGGAAGTAAATTTGGCTGTTCAAAATGCAAAGGCTGCT
TTTAAAATATGGAGTCAAAAATCTGGCATGGAGCGTTGCCGAATCCTTTTGGAGGCTGCC
AGGATAATAAGGGAACGGGAGGATGAAATTGCTACTATGGAGTGCATCAACAATGGCAAG
TCCATCTTTGAGGCCCGCTTGGACATTGACATTTCCTGGCAGTGCCTGGAGTATTATGCG
GGCTTGGCTGCATCCATGGCTGGTGAACACATCCAGCTCCCAGGTGGATCGTTTGGTTAT
ACCAGAAGAGAACCACTTGGGGTATGTGTGGGAATAGGAGCATGGAACTACCCCTTTCAG
ATTGCCTCTTGGAAGTCGGCTCCAGCATTAGCCTGTGGTAATGCCATGGTCTTTAAACCT
TCTCCCTTTACACCTGTTTCTGCATTGCTACTGGCTGAAATCTACAGTGAGGCTGGTGTA
CCTCCTGGGCTCTTCAATGTGGTGCAGGGAGGGGCTGCCACAGGCCAGTTTCTGTGTCAG
CATCCCGATGTGGCCAAAGTCTCCTTCACTGGAAGTGTGCCCACTGGCATGAAGATCATG
GAGATGTCAGCTAAAGGAATCAAACCTGTTACCTTGGAACTTGGAGGCAAATCTCCACTC
ATCATCTTCTCAGACTGTGATATGAACAATGCTGTAAAGGGGGCGCTGATGGCCAACTTC
CTCACACAAGGCCAGGTTTGCTGTAATGGCACAAGAGTATTTGTGCAGAAAGAAATTCTT
GATAAATTTACAGAGGAAGTGGTGAAACAGACCCAAAGGATTAAAATTGGAGATCCCCTT
CTGGAAGATACAAGGATGGGTCCACTCATCAACCGACCACACCTGGAGCGAGTCCTTGGG
TTTGTCAAAGTGGCAAAGGAGCAGGGTGCTAAAGTGTTATGTGGTGGAGATATATATGTA
CCTGAAGATCCCAAATTAAAGGATGGATATTACATGAGACCTTGTGTATTAACTAATTGC
AGAGACGACATGACCTGTGTGAAGGAAGAGATCTTTGGGCCTGTTATGTCCATTTTATCA
TTTGACACTGAAGCTGAGGTTCTAGAAAGAGCCAATGATACCACTTTTGGACTAGCAGCT
GGCGTCTTTACCAGGGACATCCAACGGGCTCATAGAGTGGTAGCTGAGCTTCAGGCTGGG
ACGTGCTTCATTAACAACTATAACGTCAGCCCAGTGGAGTTGCCCTTTGGTGGATATAAG
AAGTCAGGATTTGGCAGAGAGAACGGCCGTGTGACAATCGAATATTATTCACAGCTGAAG
ACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGA

# Metabolic_Enzyme_18_GenBank_ID_Gene:
U34252

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_18_Locus:
1q23.1

# Metabolic_Enzyme_18_SNPs:
rs1065756; rs11808728; rs1143659; rs11506; rs12670; rs12408101; rs1913844; rs2882006; rs10753688; rs4646891; rs4646889; rs7516126; rs12565874; rs3820362; rs10800129; rs10800128; rs7534437; rs12072634; rs4656457; rs1337442; rs2348728; rs4578194; rs12080699; rs7541817; rs10918239; rs2348727; rs3738192; rs6683969; rs12065621; rs2348734; rs16849230; rs6426930; rs12083232; rs7513998; rs12122497; rs7555787; rs4646886; rs10800127; rs10918252; rs2348729; rs4646883; rs7518869; rs10800133; rs2176151; rs4646882; rs1538115; rs10800131; rs4646897; rs6690818; rs2050619; rs10753689; rs7546084; rs12076579; rs17482717; rs4657463; rs10918235; rs11587760; rs4274037; rs12567331; rs4557947; rs1337443; rs10800130; rs10800132; rs4646895; rs16849238; rs17450889; rs12033254; rs12069198; rs6657651; rs10918245; rs3845537; rs10918237; rs11807857; rs11807866; rs884121; rs4657462; rs10918236; rs7543204; rs2184918; rs12070650; rs17417191; rs9970857; rs6662419; rs7367737; rs10918242; rs10918241; rs7546322; rs4646888; rs16849374; rs12409168; rs12037790; rs10918247; rs7537071; rs12084748; rs10918238; rs7368130; rs2348730; rs10918244; rs4233407; rs12123278; rs4646892; rs4657466; rs4576644; rs6683651; rs6667075; rs12021795; rs6683665; rs12081464; rs7546215; rs7519162; rs10918240; rs6667088; rs6669697; rs12081903; rs4646885; rs7542184; rs16849479; rs4646887; rs12072664; rs10753687; rs4646896; rs10157944; rs6668102; rs3753893; rs4657468; rs3753892; rs7553712; rs7511691; rs7554409; rs7544840; rs6426928; rs6667681; rs4646881; rs1415503; rs11555775; rs9164; rs4646902; rs6667510; rs11555774; rs4307543; rs11436915; rs34948330; rs12139219; rs34495301; rs10918248; rs1890080; rs35894201; rs4646884; rs28759374; rs12137604; rs28589393; rs34662022; rs12354157; rs10918246; rs35087657; rs34105906; rs35913333; rs34664103; rs12083492; rs2271658; rs34872122; rs7512816; rs4646893; rs7527514; rs12566251; rs1970286; rs3831954; rs2348731; rs10918249; rs35178491; rs36027739; rs35864611; rs17416948; rs4646894; rs11583089; rs12742656; rs12754903; rs12742657; rs41267568; rs4646890; rs12084651; rs4646900; rs34304173; rs13376536; rs12727801; rs41326750; rs28439296; rs12134617; rs12036561; rs35531113; rs3845536; rs36011778; rs12090132; rs7525102; rs10918250; rs3738191; rs12239517; rs4646898; rs34072474; rs34945812; rs10918251; rs1890079; rs35439339; rs36150573; rs1577847; rs12728137; rs34846458; rs4646901; rs36110991; rs12083091; rs34894576; rs6426927; rs11458950; rs1856143; rs35757606; rs41267564; rs41267566; rs35742388; rs10494446; rs10494447; rs10800123; rs10800125; rs10800126; rs10800135; rs10800136; rs10918228; rs10918229; rs10918231; rs10918254; rs10918255; rs10918256; rs11579160; rs11800476; rs11810856; rs12027066; rs12028588; rs12043815; rs12044709; rs12060366; rs12143472; rs12748251; rs1547725; rs16848876; rs16848958; rs16849041; rs16849616; rs1878074; rs1878075; rs2090281; rs2297762; rs2297763; rs2297764; rs2297765; rs3753894; rs3795540; rs4147602; rs4147604; rs4147605; rs4147610; rs4147611; rs4341347; rs7527279; rs7549511; rs7551594; rs8133; rs9333483; rs9333487; rs9919190

# Metabolic_Enzyme_18_General_References:
8786138; 10702312; 8645224; 8269919; 2925663

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
6066

# Metabolic_Enzyme_19_Name:
Alcohol dehydrogenase 1C

# Metabolic_Enzyme_19_Synonyms:
Alcohol dehydrogenase gamma subunit

# Metabolic_Enzyme_19_Gene_Name:
ADH1C

# Metabolic_Enzyme_19_Protein_Sequence:
>Alcohol dehydrogenase 1
CMSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLV
TPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGN
PRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFST
GYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGAT
ECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDS
QNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNILPFEKINEG
FDLLRSGKSIRTVLTF

# Metabolic_Enzyme_19_Number_of_Residues:
375

# Metabolic_Enzyme_19_Molecular_Weight:
39868

# Metabolic_Enzyme_19_Theoretical_pI:
8.38

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_19_Specific_Function:
An alcohol + NAD(+) = an aldehyde or ketone + NADH

# Metabolic_Enzyme_19_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_19_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_19_Signals:
None

# Metabolic_Enzyme_19_Transmembrane_Regions:
None

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_19_GenBank_ID_Protein:
28404

# Metabolic_Enzyme_19_SwissProt_ID:
ADH1G_HUMAN (P00326)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
ADH1C

# Metabolic_Enzyme_19_Geneatlas_id:
ADH1C

# Metabolic_Enzyme_19_hgnc_id:
HGNC:251

# Metabolic_Enzyme_19_PDB_ID:
1HT0

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_19_Gene_Sequence:
>1128 bp
ATGAGCACAGCAGGAAAAGTAATCAAATGCAAAGCAGCTGTGCTATGGGAGTTAAAGAAA
CCCTTTTCCATTGAGGAGGTAGAGGTTGCACCTCCTAAGGCTCATGAAGTTCGCATTAAG
ATGGTGGCTGCAGGAATCTGTCGTTCAGATGAGCATGTGGTTAGTGGCAACCTGGTGACC
CCCCTTCCTGTGATTTTAGGCCATGAGGCAGCCGGCATCGTGGAAAGTGTTGGAGAAGGG
GTGACTACAGTCAAACCAGGTGATAAAGTCATCCCGCTCTTTACTCCTCAGTGTGGAAAA
TGCAGAATTTGCAAAAACCCAGAAAGCAACTACTGCTTGAAAAATGATCTAGGCAATCCT
CGGGGGACCCTGCAGGATGGCACCAGGAGGTTCACCTGCAGCGGGAAGCCCATCCACCAC
TTCGTCGGCGTCAGCACCTTCTCCCAGTACACAGTGGTGGATGAGAATGCAGTAGCCAAA
ATTGATGCAGCCTCGCCCCTGGAGAAAGTCTGCCTCATTGGCTGTGGATTTTCGACTGGT
TATGGGTCTGCAGTCAAAGTTGCCAAGGTCACCCCAGGGTCTACCTGTGCTGTGTTTGGC
CTGGGAGGGGTCGGCCTATCTGTTGTTATGGGCTGTAAAGCAGCTGGAGCAGCCAGAATC
ATTGCTGTGGACATCAACAAGGACAAATTTGCAAAGGCTAAAGAGTTGGGTGCCACTGAA
TGCATCAACCCTCAAGACTACAAGAAACCCATTCAGGAAGTGCTAAAGGAAATGACTGAT
GGAGGTGTGGATTTTTCGTTTGAAGTCATCGGTCAGCTTGACACCATGATGGCTTCCCTG
TTATGTTGTCATGAGGCATGTGGCACAAGTGTCATTGTAGGGGTACCTCCTGATTCCCAG
AACCTCTCAATAAACCCTATGCTGCTACTGACTGGACGCACGTGGAAAGGAGCTATTTTT
GGAGGCTTTAAGAGTAAAGAATCTGTCCCCAAACTTGTGGCTGACTTTATGGCTAAGAAG
TTTTCACTGGATGCATTAATAACAAATGTTTTACCTTTTGAAAAAATAAATGAAGGATTT
GACCTGCTTCGCTCTGGAAAGAGTATCCGTACCGTCCTGACGTTTTGA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
X04299

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_19_Locus:
4q21-q23

# Metabolic_Enzyme_19_SNPs:
rs35385902; rs35719513; rs1693482; rs698; rs2241894; rs6413444; rs1042756; rs1693425; rs1789915; rs2298753; rs1391088; rs904096; rs1789911; rs1614972; rs1789898; rs1612735; rs1789921; rs3762896; rs3846449; rs283415; rs4147542; rs1789910; rs3133158; rs11936869; rs1789912; rs1442481; rs33988198; rs17586023; rs1662058; rs1662051; rs1789908; rs2298755; rs17526590; rs1789903; rs1662048; rs1789900; rs1662057; rs1693481; rs904095; rs6846835; rs1662060; rs1789920; rs6413446; rs1662049; rs1693480; rs6532815; rs1442479; rs1693427; rs35429031; rs1693453; rs13125415; rs1693476; rs6413447; rs12650330; rs1789901; rs35862892; rs3114047; rs1693471; rs283409; rs34009511; rs1662047; rs2009181; rs1789923; rs35500540; rs6413445; rs35189763; rs36050634; rs1789902; rs1693428; rs1625439; rs3114048; rs283411; rs34178057; rs34484723; rs6413448; rs35408712; rs35799067; rs283410; rs34250750; rs34551784; rs1662052; rs1662033; rs1662059; rs1662045; rs34736030; rs34664835; rs1693426; rs1442480; rs1693431; rs1789904; rs3910713; rs1693424; rs12639833; rs1662053; rs1693477; rs35221936; rs34871400; rs283416; rs1662046; rs34317813; rs34761493; rs2866153; rs1631460; rs904094; rs1693454; rs1789896; rs3114046; rs1229979; rs3098808; rs1662031; rs11499825; rs1789924; rs17028860; rs11499824; rs17586163; rs11499823; rs35963940; rs1693468; rs4147541; rs1789925; rs34436992; rs36024187; rs2584453; rs35365756; rs1629838; rs1789895; rs35478916; rs35614967; rs1693469; rs1229978; rs283413; rs34195308; rs35725608; rs2132839; rs2851298; rs1789919; rs36019411; rs1693483; rs6834363; rs34427956; rs35124782; rs33982136; rs904093; rs35088274; rs7658726; rs2298754; rs1662055; rs35191371; rs34918164; rs1789905; rs3133157; rs35090494; rs35470995; rs34661405; rs13118501; rs1693456; rs35418122; rs34057349; rs2903199; rs36052336; rs2851299; rs13118443; rs3216150; rs1975438; rs13147169; rs35920708; rs1662056; rs34579771; rs1789917; rs34804188; rs1789906; rs2132838; rs35081954; rs13147189; rs35381492; rs1693430; rs1693429; rs1693474; rs3960879; rs10634918; rs35735210; rs6148597; rs34782639; rs1629270; rs283414; rs1789914; rs1789916; rs35733876; rs34936799; rs35420886; rs34379379; rs1662035; rs6148596; rs283412; rs172223; rs1789913; rs5860576; rs35801274; rs34480181; rs3098809; rs35293095; rs1662030; rs36095748; rs34774688; rs1662032; rs35691997; rs35978141; rs34328535; rs34484557; rs1154432; rs1154433; rs1229851; rs1229852; rs1229853; rs1229854; rs1229863; rs1229864; rs1229980; rs1614377; rs1662037; rs1662039; rs166892; rs1693470; rs17586246; rs1789890; rs1789891; rs2584455; rs2851300; rs2866152; rs4699741; rs980972

# Metabolic_Enzyme_19_General_References:
3758060; 2935875; 1524834; 6391921

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
5591

# Metabolic_Enzyme_20_Name:
Sulfotransferase family cytosolic 2B member 1

# Metabolic_Enzyme_20_Synonyms:
Sulfotransferase 2B1; Alcohol sulfotransferase; Hydroxysteroid sulfotransferase 2

# Metabolic_Enzyme_20_Gene_Name:
SULT2B1

# Metabolic_Enzyme_20_Protein_Sequence:
>Sulfotransferase family cytosolic 2B member 1
MDGPAEPQIPGLWDTYEDDISEISQKLPGEYFRYKGVPFPVGLYSLESISLAENTQDVRD
DDIFIITYPK
SGTTWMIEIICLILKEGDPSWIRSVPIWERAPWCETIVGAFSLPDQYSP
RLMSSHLPIQIFTKAFFSSKA
KVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLRD
FLKGEVQFGSWFDHIKGWLRMKGKDNFLFITY
EELQQDLQGSVERICGFLGRPLGKEAL
GSVVAHSTFSAMKANTMSNYTLLPPSLLDHRRGAFLRKGVCGD
WKNHFTVAQSEAFDRA
YRKQMRGMPTFPWDEDPEEDGSPDPEPSPEPEPKPSLEPNTSLEREPRPNSSPS
PSPGQ
ASETPHPRPS

# Metabolic_Enzyme_20_Number_of_Residues:
365

# Metabolic_Enzyme_20_Molecular_Weight:
41308

# Metabolic_Enzyme_20_Theoretical_pI:
5.05

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_20_General_Function:
Not Available

# Metabolic_Enzyme_20_Specific_Function:
Catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol

# Metabolic_Enzyme_20_Pathway:
map00150  Androgen and estrogen metabolism;
 map00920  Sulfur metabolism

# Metabolic_Enzyme_20_Reaction:
3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_20_Signals:
None

# Metabolic_Enzyme_20_Transmembrane_Regions:
None

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 2.8.2.2

# Metabolic_Enzyme_20_GenBank_ID_Protein:
1923291

# Metabolic_Enzyme_20_SwissProt_ID:
ST2B1_HUMAN (O00204)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
SULT2B1

# Metabolic_Enzyme_20_Geneatlas_id:
SULT2B1

# Metabolic_Enzyme_20_hgnc_id:
HGNC:11459

# Metabolic_Enzyme_20_PDB_ID:
1Q1Q

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_20_Gene_Sequence:
>1053 bp

ATGGCGTCTCCCCCACCTTTCCACAGCCAGAAGTTGCCAGGTGAATACTTCCGGTACAA
GGGCGTCCCCT
TCCCCGTCGGCCTGTACTCGCTCGAGAGCATCAGCTTGGCGGAGAACA
CCCAAGATGTGCGGGACGACGA
CATCTTTATCATCACCTACCCCAAGTCAGGCACGACC
TGGATGATCGAGATCATCTGCTTAATCCTGAAG
GAAGGGGATCCATCCTGGATCCGCTC
CGTGCCCATCTGGGAGCGGGCACCCTGGTGTGAGACCATTGTGG
GTGCTTTCAGCCTCC
CGGACCAGTACAGCCCCCGCCTCATGAGCTCCCATCTTCCCATCCAGATCTTCAC
CAAG
GCCTTCTTCAGCTCCAAGGCCAAGGTGATCTACATGGGCCGCAACCCCCGGGACGTTGTG
GTCTCC
CTCTATCATTACTCCAAGATCGCCGGGCAGTTAAAGGACCCGGGCACACCCGA
CCAGTTCCTGAGGGACT
TCCTCAAAGGCGAAGTGCAGTTTGGCTCCTGGTTCGACCACA
TTAAGGGCTGGCTTCGGATGAAGGGCAA
AGACAACTTCCTATTTATCACCTACGAGGAG
CTGCAGCAGGACTTACAGGGCTCCGTGGAGCGCATCTGT
GGGTTCCTGGGCCGTCCGCT
GGGCAAGGAGGCACTGGGCTCCGTCGTGGCACACTCAACCTTCAGCGCCA
TGAAGGCCA
ACACCATGTCCAACTACACGCTGCTGCCTCCCAGCCTGCTGGACCACCGTCGCGGGGCCT
T
CCTCCGGAAAGGGGTCTGCGGCGACTGGAAGAACCACTTCACGGTGGCCCAGAGCGAA
GCCTTCGATCGT
GCCTACCGCAAGCAGATGCGGGGGATGCCGACCTTCCCCTGGGATGA
AGACCCGGAGGAGGATGGCAGCC
CAGATCCTGAGCCCAGCCCTGAGCCTGAGCCCAAGC
CCAGCCTTGAGCCCAACACCAGCCTGGAGCGTGA
GCCCAGACCCAACTCCAGCCCCAAC
CCCAGCCCCGGCCAGGCCTCTGAGACCCCGCACCCACGACCCTCA
TAA

# Metabolic_Enzyme_20_GenBank_ID_Gene:
U92314

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_20_Locus:
19q13.3

# Metabolic_Enzyme_20_SNPs:
rs2302947; rs2544794; rs1132054; rs2302948; rs1052131; rs2431141; rs3815691; rs12460535; rs4149455; rs2544789; rs10416980; rs3760802; rs3760800; rs8109054; rs2544788; rs10424976; rs8109050; rs4802489; rs11083943; rs2544785; rs6509396; rs2544784; rs10426377; rs175924; rs2544783; rs8108904; rs3745726; rs3848542; rs12611137; rs2544787; rs4802495; rs11672175; rs4801764; rs11880293; rs4080470; rs10417472; rs10401347; rs8108022; rs11880831; rs4149456; rs10425691; rs2665601; rs11882923; rs11083944; rs10420140; rs12462337; rs2544786; rs6509393; rs2665605; rs11881295; rs7248376; rs10426193; rs2544800; rs6509397; rs10425172; rs7249780; rs3760808; rs4801766; rs10420172; rs10424445; rs2665586; rs10418193; rs2665580; rs4080469; rs3760804; rs12611168; rs10424655; rs4802490; rs8109679; rs12462087; rs8106759; rs2665583; rs9304677; rs7249118; rs3909296; rs6509392; rs3826827; rs10424237; rs4802491; rs10418222; rs12981320; rs12608902; rs2665606; rs8111787; rs11878385; rs11880848; rs6509394; rs2665584; rs12976976; rs7409348; rs2379081; rs2544793; rs3760805; rs7408540; rs12611151; rs4801768; rs2665582; rs34373168; rs8112135; rs6509391; rs12611128; rs12610737; rs11882607; rs11083946; rs2665577; rs10426563; rs3786749; rs7248627; rs2665587; rs3786750; rs2665581; rs10415318; rs12611192; rs4801765; rs9676424; rs3909295; rs10404801; rs11882405; rs2302949; rs11083945; rs2544795; rs9676516; rs12977025; rs7258739; rs12975397; rs10426628; rs2544790; rs2379085; rs7246557; rs7255533; rs9973264; rs11666506; rs13347093; rs2665600; rs2544804; rs10422117; rs8107786; rs2246836; rs10419482; rs9676485; rs12460513; rs8108917; rs8108812; rs7257121; rs2665604; rs12981299; rs12981760; rs10403171; rs10420304; rs2665579; rs10422717; rs12608918; rs8107219; rs11878647; rs2665575; rs12977008; rs12611181; rs8100256; rs3815692; rs8103525; rs6509395; rs11083942; rs10416165; rs11672291; rs279447; rs2246837; rs3859437; rs2665603; rs11671705; rs2665574; rs10420892; rs2665602; rs12611119; rs2544801; rs11882293; rs10416119; rs8113355; rs10410524; rs12609189; rs279449; rs11878685; rs1052124; rs5828356; rs11286832; rs2544799; rs34578466; rs10589655; rs11083941; rs2544802; rs34808712; rs35790289; rs2544792; rs10648968; rs34429366; rs10427068; rs34768198; rs279446; rs12980918; rs28626601; rs9676509; rs10407019; rs34332722; rs2665576; rs34698909; rs35448535; rs10577756; rs11878722; rs8104499; rs36003772; rs2544782; rs34741298; rs3837954; rs10411546; rs34625801; rs2544796; rs3859438; rs2941502; rs2544798; rs9676465; rs7259869; rs2544803; rs10421116; rs34399820; rs35503043; rs9789258; rs10411304; rs2665596; rs11285675; rs35536990; rs10581692; rs11881377; rs9789261; rs4802492; rs8108788; rs2544791; rs2544781; rs34482710; rs35921662; rs2379089; rs35197699; rs2379082; rs34353616; rs8109498; rs9676529; rs28446557; rs4011542; rs12983435; rs11666287; rs35450632; rs10417160; rs7259862; rs13343592; rs35211958; rs2665597; rs11671834; rs279445; rs10423750; rs34345412; rs35813972; rs10402100; rs3760806; rs3833253; rs10426286; rs12974007; rs3760801; rs28411253; rs35375190; rs34154386; rs35544342; rs34107488; rs2665578; rs12104307; rs2665599; rs10408348; rs35172026; rs10668221; rs35747850; rs34522310; rs7256244; rs35749262; rs10424430; rs34520151; rs12981151; rs36088037; rs35221052; rs5828354; rs34704123; rs35905762; rs2665590; rs28439983; rs2665585; rs3843745; rs34512399; rs12976785; rs2665608; rs10425879; rs28370904; rs11879142; rs4801767; rs34945864; rs10407495; rs3760807; rs2379083; rs12979357; rs11882313; rs2544797; rs11668970; rs36014830; rs5828355; rs3893696; rs11453549; rs2890071; rs34812578; rs28366580; rs2665598; rs12979991; rs10552230; rs35186872; rs10549281; rs10405920; rs2665607; rs34974937; rs34230215; rs10427087; rs34886384; rs3760803; rs35280795; rs11880900; rs2379084; rs35679165; rs34813342; rs10415492; rs35078110; rs28759208; rs8108153; rs2665588; rs12980615; rs3837955; rs34622126; rs10639250; rs279448; rs10415861; rs279450; rs10413911; rs1236093; rs12460223; rs12611321; rs12981419; rs16982137; rs16982149; rs16982159; rs17842463; rs2544808; rs2617805; rs2665591; rs2665593; rs279451; rs279452; rs34439264; rs3745727; rs378333; rs402209; rs411482; rs9807810

# Metabolic_Enzyme_20_General_References:
9799594; 12145317; 12923182

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
6326

# Metabolic_Enzyme_21_Name:
Cytochrome P450 2C19

# Metabolic_Enzyme_21_Synonyms:
(R-limonene 6-monooxygenase; (S-limonene 6-monooxygenase; (S- limonene 7-monooxygenase; CYPIIC19; P450-11A; Mephenytoin 4- hydroxylase; CYPIIC17; P450-254C

# Metabolic_Enzyme_21_Gene_Name:
CYP2C19

# Metabolic_Enzyme_21_Protein_Sequence:
>Cytochrome P450 2C19
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI
YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM
ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYID
LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK
KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP
PFYQLCFIPV

# Metabolic_Enzyme_21_Number_of_Residues:
490

# Metabolic_Enzyme_21_Molecular_Weight:
55932

# Metabolic_Enzyme_21_Theoretical_pI:
7.42

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_21_Specific_Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine

# Metabolic_Enzyme_21_Pathway:
map00902  Monoterpenoid biosynthesis;
 map00903  Limonene and pinene degradation;
GENES       HSA: 1559(CYP2C9)

# Metabolic_Enzyme_21_Reaction:
(+)-(R)-limonene + NADPH + H+ + O2 = (+)-trans-carveol + NADP+ + H2O

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_21_Signals:
1-25

# Metabolic_Enzyme_21_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 1.14.13.80;EC 1.14.13.

# Metabolic_Enzyme_21_GenBank_ID_Protein:
181344

# Metabolic_Enzyme_21_SwissProt_ID:
CP2CJ_HUMAN (P33261)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
CYP2C19

# Metabolic_Enzyme_21_Geneatlas_id:
CYP2C19

# Metabolic_Enzyme_21_hgnc_id:
HGNC:2621

# Metabolic_Enzyme_21_PDB_ID:
1R9O

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein

# Metabolic_Enzyme_21_Gene_Sequence:
>1473 bp
ATGGATCCTTTTGTGGTCCTTGTGCTCTGTCTCTCATGTTTGCTTCTCCTTTCAATCTGG
AGACAGAGCTCTGGGAGAGGAAAACTCCCTCCTGGCCCCACTCCTCTCCCAGTGATTGGA
AATATCCTACAGATAGATATTAAGGATGTCAGCAAATCCTTAACCAATCTCTCAAAAATC
TATGGCCCTGTGTTCACTCTGTATTTTGGCCTGGAACGCATGGTGGTGCTGCATGGATAT
GAAGTGGTGAAGGAAGCCCTGATTGATCTTGGAGAGGAGTTTTCTGGAAGAGGCCATTTC
CCACTGGCTGAAAGAGCTAACAGAGGATTTGGAATCGTTTTCAGCAATGGAAAGAGATGG
AAGGAGATCCGGCGTTTCTCCCTCATGACGCTGCGGAATTTTGGGATGGGGAAGAGGAGC
ATTGAGGACCGTGTTCAAGAGGAAGCCCGCTGCCTTGTGGAGGAGTTGAGAAAAACCAAG
GCTTCACCCTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCC
ATTATTTTCCAGAAACGTTTCGATTATAAAGATCAGCAATTTCTTAACTTGATGGAAAAA
TTGAATGAAAACATCAGGATTGTAAGCACCCCCTGGATCCAGATATGCAATAATTTTCCC
ACTATCATTGATTATTTCCCGGGAACCCATAACAAATTACTTAAAAACCTTGCTTTTATG
GAAAGTGATATTTTGGAGAAAGTAAAAGAACACCAAGAATCGATGGACATCAACAACCCT
CGGGACTTTATTGATTGCTTCCTGATCAAAATGGAGAAGGAAAAGCAAAACCAACAGTCT
GAATTCACTATTGAAAACTTGGTAATCACTGCAGCTGACTTACTTGGAGCTGGGACAGAG
ACAACAAGCACAACCCTGAGATATGCTCTCCTTCTCCTGCTGAAGCACCCAGAGGTCACA
GCTAAAGTCCAGGAAGAGATTGAACGTGTCATTGGCAGAAACCGGAGCCCCTGCATGCAG
GACAGGGGCCACATGCCCTACACAGATGCTGTGGTGCACGAGGTCCAGAGATACATCGAC
CTCATCCCCACCAGCCTGCCCCATGCAGTGACCTGTGACGTTAAATTCAGAAACTACCTC
ATTCCCAAGGGCACAACCATATTAACTTCCCTCACTTCTGTGCTACATGACAACAAAGAA
TTTCCCAACCCAGAGATGTTTGACCCTCGTCACTTTCTGGATGAAGGTGGAAATTTTAAG
AAAAGTAACTACTTCATGCCTTTCTCAGCAGGAAAACGGATTTGTGTGGGAGAGGGCCTG
GCCCGCATGGAGCTGTTTTTATTCCTGACCTTCATTTTACAGAACTTTAACCTGAAATCT
CTGATTGACCCAAAGGACCTTGACACAACTCCTGTTGTCAATGGATTTGCTTCTGTCCCG
CCCTTCTATCAGCTGTGCTTCATTCCTGTCTGA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
M61854

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_21_Locus:
10q24.1-q24.3

# Metabolic_Enzyme_21_SNPs:
rs4986893; rs3758581; rs17878459; rs4244285; rs3758580; rs17885098; rs17886522; rs7079533; rs11597626; rs4388808; rs4917623; rs1322179; rs6583954; rs4417205; rs12098606; rs17885348; rs17884938; rs17885567; rs7918461; rs10509677; rs7916649; rs10786172; rs4244284; rs7088784; rs11592737; rs7915414; rs1853205; rs3853515; rs4304697; rs1322181; rs4617515; rs17885417; rs7081643; rs10509678; rs12779363; rs1555474; rs11188092; rs17884832; rs17878627; rs12253253; rs17881883; rs12773342; rs17882222; rs11528090; rs9664621; rs4451645; rs17882547; rs9664361; rs7068577; rs11597292; rs7086313; rs17884928; rs11813465; rs11188089; rs11188091; rs4641393; rs17879263; rs11188093; rs11595907; rs2104161; rs7091883; rs9663112; rs11596729; rs12573281; rs12571421; rs9663219; rs17882066; rs17884974; rs7077029; rs17879466; rs12268020; rs12218984; rs17880188; rs17878673; rs10509676; rs12247175; rs12768009; rs9663214; rs17878382; rs9663965; rs12767583; rs7081559; rs17885052; rs7919524; rs7076598; rs17882201; rs11188087; rs17879992; rs17878649; rs11596777; rs12778026; rs10748628; rs10882498; rs9663206; rs4362080; rs12572917; rs12569455; rs12572085; rs11188074; rs12218223; rs17885308; rs7076898; rs12769205; rs12761391; rs1972341; rs17882345; rs11568732; rs12248560; rs3814637; rs4986894; rs17880036; rs7902257; rs5787121; rs6413438; rs17884712; rs17885179; rs28399504; rs28399505; rs28399510; rs41291556; rs17882687; rs17879685; rs17879239; rs28399514; rs17882291; rs17882744; rs11498699; rs9664368; rs12763180; rs11188086; rs2264939; rs9664553; rs35554433; rs17880980; rs2264940; rs34503067; rs11188078; rs34498672; rs11188090; rs34468815; rs28399511; rs17879729; rs35421605; rs11528087; rs34121168; rs9783199; rs10454474; rs7476824; rs12572478; rs12357854; rs4110515; rs11188082; rs17878606; rs34059718; rs34683025; rs12246578; rs7909467; rs7086525; rs34126197; rs35577798; rs17882507; rs12775283; rs11188085; rs9630086; rs34523983; rs2984314; rs12221433; rs34258504; rs2984315; rs17885915; rs11188094; rs4494250; rs11188073; rs7394219; rs2264938; rs41291558; rs7078494; rs1853209; rs17882839; rs11813865; rs11597811; rs12218975; rs17879150; rs2984318; rs11498700; rs17883850; rs2093435; rs12268172; rs35553115; rs2984328; rs35739901; rs17885978; rs12217240; rs11498525; rs4501922; rs34815130; rs17882412; rs11528086; rs17879918; rs4396216; rs35390752; rs4414147; rs2264935; rs17882572; rs36148720; rs28872185; rs36190903; rs28399506; rs35163153; rs11461829; rs2260946; rs17878937; rs17878279; rs4447102; rs35414916; rs17885958; rs34100740; rs12268235; rs7911654; rs35399877; rs36185424; rs17879750; rs11517027; rs10748625; rs4445573; rs2984317; rs28399513; rs35191672; rs7096146; rs7393360; rs2264937; rs35577300; rs12772139; rs2757483; rs4277036; rs2264934; rs2984329; rs11188079; rs12416196; rs34374889; rs2984321; rs34647676; rs17879440; rs1923377; rs12256208; rs11364900; rs12772672; rs12248975; rs17879629; rs17886017; rs12218972; rs10624873; rs11819481; rs35337223; rs11498523; rs35781911; rs11528085; rs35476215; rs34312574; rs34983326; rs2984319; rs17882089; rs17879677; rs2260939; rs11188075; rs7072110; rs2264936; rs11188081; rs2984330; rs34648834; rs17884823; rs4917612; rs4291603; rs2984316; rs34737722; rs11498522; rs17887022; rs12251223; rs2224566; rs17878981; rs35182703; rs34017578; rs34707411; rs17886482; rs7911008; rs17878682; rs2264933; rs6144036; rs17878417; rs35442644; rs34058919; rs35751085; rs28399509; rs2984320; rs11188095; rs17882646; rs3980277; rs34986692; rs12258243; rs10082434; rs17878972; rs28399515; rs17887130; rs34897610; rs17882329; rs17882796; rs41317284; rs17879512; rs17886301; rs17878739; rs17885857; rs11188097; rs11568730; rs1998322; rs3862009; rs4400728; rs4532967; rs7094377; rs7101258; rs733115; rs941890

# Metabolic_Enzyme_21_General_References:
2009263; 8095407; 11950794; 8195181; 7969038; 9103550; 9732415; 10022751; 10411572

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
5772

# Metabolic_Enzyme_22_Name:
Acetylcholinesterase precursor

# Metabolic_Enzyme_22_Synonyms:
AChE

# Metabolic_Enzyme_22_Gene_Name:
ACHE

# Metabolic_Enzyme_22_Protein_Sequence:
>Acetylcholinesterase precursor
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL

# Metabolic_Enzyme_22_Number_of_Residues:
614

# Metabolic_Enzyme_22_Molecular_Weight:
67797

# Metabolic_Enzyme_22_Theoretical_pI:
6.24

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  cholinesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_22_Specific_Function:
Rapidly hydrolyzes choline released into the synapse

# Metabolic_Enzyme_22_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_22_Reaction:
acetylcholine + H2O = choline + acetate

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF08674:AChE_tetra;
PF00135:COesterase

# Metabolic_Enzyme_22_Signals:
1-31

# Metabolic_Enzyme_22_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 3.1.1.7

# Metabolic_Enzyme_22_GenBank_ID_Protein:
177975

# Metabolic_Enzyme_22_SwissProt_ID:
ACES_HUMAN (P22303)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
ACHE

# Metabolic_Enzyme_22_Geneatlas_id:
ACHE

# Metabolic_Enzyme_22_hgnc_id:
HGNC:108

# Metabolic_Enzyme_22_PDB_ID:
1F8U

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_22_Gene_Sequence:
>1845 bp
ATGAGGCCCCCGCAGTGTCTGCTGCACACGCCTTCCCTGGCTTCCCCACTCCTTCTCCTC
CTCCTCTGGCTCCTGGGTGGAGGAGTGGGGGCTGAGGGCCGGGAGGATGCAGAGCTGCTG
GTGACGGTGCGTGGGGGCCGGCTGCGGGGCATTCGCCTGAAGACCCCCGGGGGCCCTGTC
TCTGCTTTCCTGGGCATCCCCTTTGCGGAGCCACCCATGGGACCCCGTCGCTTTCTGCCA
CCGGAGCCCAAGCAGCCTTGGTCAGGGGTGGTAGACGCTACAACCTTCCAGAGTGTCTGC
TACCAATATGTGGACACCCTATACCCAGGTTTTGAGGGCACCGAGATGTGGAACCCCAAC
CGTGAGCTGAGCGAGGACTGCCTGTACCTCAACGTGTGGACACCATACCCCCGGCCTACA
TCCCCCACCCCTGTCCTCGTCTGGATCTATGGGGGTGGCTTCTACAGTGGGGCCTCCTCC
TTGGACGTGTACGATGGCCGCTTCTTGGTACAGGCCGAGAGGACTGTGCTGGTGTCCATG
AACTACCGGGTGGGAGCCTTTGGCTTCCTGGCCCTGCCGGGGAGCCGAGAGGCCCCGGGC
AATGTGGGTCTCCTGGATCAGAGGCTGGCCCTGCAGTGGGTGCAGGAGAACGTGGCAGCC
TTCGGGGGTGACCCGACATCAGTGACGCTGTTTGGGGAGAGCGCGGGAGCCGCCTCGGTG
GGCATGCACCTGCTGTCCCCGCCCAGCCGGGGCCTGTTCCACAGGGCCGTGCTGCAGAGC
GGTGCCCCCAATGGACCCTGGGCCACGGTGGGCATGGGAGAGGCCCGTCGCAGGGCCACG
CAGCTGGCCCACCTTGTGGGCTGTCCTCCAGGCGGCACTGGTGGGAATGACACAGAGCTG
GTAGCCTGCCTTCGGACACGACCAGCGCAGGTCCTGGTGAACCACGAATGGCACGTGCTG
CCTCAAGAAAGCGTCTTCCGGTTCTCCTTCGTGCCTGTGGTAGATGGAGACTTCCTCAGT
GACACCCCAGAGGCCCTCATCAACGCGGGAGACTTCCACGGCCTGCAGGTGCTGGTGGGT
GTGGTGAAGGATGAGGGCTCGTATTTTCTGGTTTACGGGGCCCCAGGCTTCAGCAAAGAC
AACGAGTCTCTCATCAGCCGGGCCGAGTTCCTGGCCGGGGTGCGGGTCGGGGTTCCCCAG
GTAAGTGACCTGGCAGCCGAGGCTGTGGTCCTGCATTACACAGACTGGCTGCATCCCGAG
GACCCGGCACGCCTGAGGGAGGCCCTGAGCGATGTGGTGGGCGACCACAATGTCGTGTGC
CCCGTGGCCCAGCTGGCTGGGCGACTGGCTGCCCAGGGTGCCCGGGTCTACGCCTACGTC
TTTGAACACCGTGCTTCCACGCTCTCCTGGCCCCTGTGGATGGGGGTGCCCCACGGCTAC
GAGATCGAGTTCATCTTTGGGATCCCCCTGGACCCCTCTCGAAACTACACGGCAGAGGAG
AAAATCTTCGCCCAGCGACTGATGCGATACTGGGCCAACTTTGCCCGCACAGGGGATCCC
AATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAG
TACGTTAGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGC
GCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCCACCGACACGCTCGACGAGGCG
GAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAAC
CAGTTCGACCACTACAGCAAGCAGGATCGCTGCTCAGACCTGTGA

# Metabolic_Enzyme_22_GenBank_ID_Gene:
M55040

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_22_Locus:
7q22

# Metabolic_Enzyme_22_SNPs:
Not Available

# Metabolic_Enzyme_22_General_References:
2263619; 12853948; 11239002; 8299725; 2714437; 1748670; 1517212; 9640563; 11053835; 8488842

# Metabolic_Enzyme_22_References:
17077538; 17082743

# Metabolic_Enzyme_23_ID:
8565

# Metabolic_Enzyme_23_Name:
Hypothetical protein HMFT2263

# Metabolic_Enzyme_23_Synonyms:
Not Available

# Metabolic_Enzyme_23_Gene_Name:
HMFT2263

# Metabolic_Enzyme_23_Protein_Sequence:
>Hypothetical protein HMFT2263
DVDDGLAAVGYSKADIPALVKGTLPQERVTKLAPRPQSEEDLAALFEASMKLY

# Metabolic_Enzyme_23_Number_of_Residues:
53

# Metabolic_Enzyme_23_Molecular_Weight:
5690

# Metabolic_Enzyme_23_Theoretical_pI:
4.33

# Metabolic_Enzyme_23_GO_Classification:
Not Available

# Metabolic_Enzyme_23_General_Function:
Not Available

# Metabolic_Enzyme_23_Specific_Function:
Not Available

# Metabolic_Enzyme_23_Pathway:
Not Available

# Metabolic_Enzyme_23_Reaction:
Not Available

# Metabolic_Enzyme_23_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_23_Signals:
Not Available

# Metabolic_Enzyme_23_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_23_GenBank_ID_Protein:
51555812

# Metabolic_Enzyme_23_SwissProt_ID:
Q68CI7_HUMAN (Q68CI7)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
HMFT2263

# Metabolic_Enzyme_23_Geneatlas_id:
HMFT2263

# Metabolic_Enzyme_23_hgnc_id:
HGNC:16354

# Metabolic_Enzyme_23_PDB_ID:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Not Available

# Metabolic_Enzyme_23_Gene_Sequence:
Not Available

# Metabolic_Enzyme_23_GenBank_ID_Gene:
AB075879

# Metabolic_Enzyme_23_Chromosome_Location:
Not Available

# Metabolic_Enzyme_23_Locus:
Not Available

# Metabolic_Enzyme_23_SNPs:
Not Available

# Metabolic_Enzyme_23_General_References:
Not Available

# Metabolic_Enzyme_23_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7086

# Macromolecular_Interacting_Partner_1_Name:
D(2) dopamine receptor

# Macromolecular_Interacting_Partner_1_Synonyms:
Dopamine D2 receptor

# Macromolecular_Interacting_Partner_1_Gene_Name:
DRD2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>D2 dopamine receptor
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
443

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
50620

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
9.85

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  amine receptor activity
Function:  dopamine receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
38-60
72-97
109-130
152-174
187-210
374-397
406-429

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
563756

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
DRD2_HUMAN (P14416)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
DRD2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
DRD2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:3023

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>66 bp
ATGCGGCGGGAGCTGGAAGCCTCAAGCAGCCGGCGCCGTCTCTGCCCCCGGGGCCCTATG
GCTTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M30625

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11q23

# Macromolecular_Interacting_Partner_1_SNPs:
rs1801028; rs1800496; rs6277; rs6275; rs1800499; rs4986918; rs4986921; rs4986923; rs1125394; rs2471857; rs1076563; rs7109615; rs4581480; rs7934416; rs7350522; rs6279; rs4245149; rs4586205; rs11214608; rs4245148; rs4436578; rs10891552; rs4938019; rs4648319; rs7131056; rs7125415; rs4245147; rs6278; rs1079596; rs1125393; rs4936271; rs4587762; rs4630328; rs4938017; rs6276; rs4936270; rs1116313; rs7122246; rs7102650; rs12574471; rs12800853; rs4274224; rs7103679; rs17529477; rs11601054; rs12364051; rs4936274; rs17115583; rs7131440; rs1079597; rs4460839; rs11214613; rs4620755; rs1079598; rs4350392; rs11214605; rs4245145; rs4648317; rs7122454; rs7118161; rs11214606; rs1076562; rs4938018; rs2471854; rs11214611; rs7948028; rs4245146; rs7937704; rs17115596; rs11608109; rs7131627; rs7131465; rs12805897; rs12417342; rs9282673; rs9282672; rs6274; rs7109897; rs17601612; rs34164777; rs7131681; rs10891550; rs35659571; rs2471851; rs7117847; rs10891551; rs12283680; rs7118174; rs12799083; rs12421616; rs10789943; rs7118024; rs2471856; rs2471850; rs11214607; rs11214612; rs12421264; rs2471848; rs10789944; rs10891553; rs7117915; rs12417718; rs4648318; rs4936272; rs4322431; rs2734837; rs1079594; rs2734841; rs1124493; rs1124491; rs2587548; rs1800498; rs1079595; rs2734836; rs2362873; rs1124492; rs2734833; rs1107162; rs1076560; rs2245805; rs1079727; rs2734838; rs2075654; rs2002453; rs2234690; rs2734839; rs2005313; rs12363125; rs1079721; rs11608185; rs4986920; rs12808482; rs2511521; rs2075652; rs2283265; rs2734835; rs2440390; rs2734831; rs2242592; rs2242591; rs10891549; rs1554929; rs1799978; rs2734842; rs12364283; rs2234689; rs1110977; rs11214604; rs35675212; rs34609702; rs34126713; rs35145680; rs2471855; rs11214610; rs1130354; rs34286726; rs34760436; rs7939472; rs10544310; rs3935565; rs35921774; rs34045234; rs36009253; rs36152573; rs35080812; rs1882765; rs36083757; rs12276545; rs10554769; rs12225915; rs34771705; rs36101312; rs11214616; rs7118628; rs6144513; rs7126289; rs4986922; rs12291794; rs10536949; rs35383923; rs35206875; rs34755690; rs34535530; rs34992190; rs34632468; rs11214615; rs11439751; rs6273; rs34735140; rs5794865; rs7131443; rs5794866; rs34063793; rs28685216; rs35826108; rs11214614; rs36102234; rs2471849; rs4337071; rs34179357; rs12798900; rs12576411; rs4379875; rs7930567; rs35751498; rs7116768; rs10652849; rs10707068; rs4533070; rs34322013; rs35033827; rs10891554; rs35610061; rs1124469; rs34684460; rs34083584; rs34674946; rs35319840; rs34986358; rs34554234; rs5794863; rs1110976; rs34216456; rs17115475; rs1076561; rs35352421; rs35299201; rs34135920; rs34113117; rs36019021; rs35608204; rs10622802; rs5794864; rs1962262; rs35579712; rs35685394; rs1124470; rs35761620; rs3060174; rs34914014; rs17505337; rs34525623; rs1110975; rs5794862; rs12098980; rs34482574; rs5013059; rs2587542; rs2734843; rs5013061; rs5013060; rs1554928; rs34681050; rs10547477; rs5794867; rs11351536; rs5013062; rs1799732; rs5794868; rs10637059; rs10547478; rs12281924; rs10546823; rs2734844; rs36070058; rs11214603; rs1003641; rs1005104; rs1005105; rs1005106; rs10891556; rs11214599; rs11214601; rs11214602; rs11214618; rs12422191; rs12794908; rs1800497; rs1882764; rs2242593; rs2471853; rs2511520; rs2516346; rs2587543; rs2587544; rs2587545; rs2587546; rs2587547; rs2587550; rs2587551; rs2587552; rs2587553; rs2734832; rs2734845; rs2734848; rs2859543; rs2859544; rs2859545; rs4254098; rs4307755; rs4424703; rs4483623; rs6589377; rs7110440

# Macromolecular_Interacting_Partner_1_General_References:
2533064; 2531656; 2138729; 2532362; 2137193; 2144985; 1363862; 1835903; 8471125; 10719223; 7902708; 10220438

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
5754

# Macromolecular_Interacting_Partner_2_Name:
Alcohol dehydrogenase [NADP+]

# Macromolecular_Interacting_Partner_2_Synonyms:
Aldehyde reductase; Aldo- keto reductase family 1 member A1

# Macromolecular_Interacting_Partner_2_Gene_Name:
AKR1A1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Alcohol dehydrogenase NADP+
MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL
KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER
GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP
AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK
YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV
PMLTVDGKRVPRDAGHPLYPFNDPY

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
325

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
36573

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.79

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Catalyzes the NADPH-dependent reduction of a variety of aldehydes to their corresponding alcohols

# Macromolecular_Interacting_Partner_2_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00561  Glycerolipid metabolism;
 map00930  Caprolactam degradation

# Macromolecular_Interacting_Partner_2_Reaction:
an alcohol + NADP+ = an aldehyde + NADPH + H+

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
EC 1.1.1.2

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
178481

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
AK1A1_HUMAN (P14550)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
AKR1A1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
AKR1A1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:380

# Macromolecular_Interacting_Partner_2_PDB_ID:
2ALR

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>978 bp
ATGGCGGCTTCCTGTGTTCTACTGCACACTGGGCAGAAGATGCCTCTGATTGGTCTGGGT
ACCTGGAAGAGTGAGCCTGGTCAGGTAAAAGCAGCTGTTAAGTATGCCCTTAGCGTAGGC
TACCGCCACATTGATTGTGCTGCTATCTACGGCAATGAGCCTGAGATTGGGGAGGCCCTG
AAGGAGGACGTGGGACCAGGCAAGGCGGTGCCTCGGGAGGAGCTGTTTGTGACATCCAAG
CTGTGGAACACCAAGCACCACCCCGAGGATGTGGAGCCTGCCCTCCGGAAGACTCTGGCT
GACCTCCAGCTGGAGTATCTGGACCTGTACCTGATGCACTGGCCTTATGCCTTTGAGCGG
GGAGACAACCCCTTCCCCAAGAATGCTGATGGGACTATATGCTACGACTCCACCCACTAC
AAGGAGACTTGGAAGGCTCTGGAGGCACTGGTGGCTAAGGGGCTGGTGCAGGCGCTGGGC
CTGTCCAACTTCAACAGTCGGCAGATTGATGACATACTCAGTGTGGCCTCCGTGCGTCCA
GCTGTCTTGCAGGTGGAATGCCACCCATACTTGGCTCAAAATGAGCTAATTGCCCACTGC
CAAGCACGTGGCTTGGAGGTAACTGCTTATAGCCCTTTGGGCTCCTCTGATCGTGCATGG
CGTGATCCTGATGAGCCTGTCCTGCTGGAGGAACCAGTAGTCCTGGCATTGGCTGAAAAG
TATGGCCGATCTCCAGCTCAGATCTTGCTCAGGTGGCAGGTCCAGCGGAAAGTGATCTGC
ATCCCCAAAAGTATCACTCCTTCTCGAATCCTTCAGAACATCAAGGTGTTTGACTTCACC
TTTAGCCCAGAAGAGATGAAGCAGCTAAATGCCCTGAACAAAAATTGGAGATATATTGTG
CCTATGCTTACGGTGGATGGGAAGAGAGTCCCAAGGGATGCAGGGCATCCTCTGTACCCC
TTTAATGACCCGTACTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
J04794

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Locus:
Not Available

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
2498333; 10486210; 3615425; 7669785

# Macromolecular_Interacting_Partner_2_References:
11762132; 11893554; 14722082

# Macromolecular_Interacting_Partner_3_ID:
6840

# Macromolecular_Interacting_Partner_3_Name:
Cytochrome P450 2E1

# Macromolecular_Interacting_Partner_3_Synonyms:
CYPIIE1; P450-J

# Macromolecular_Interacting_Partner_3_Gene_Name:
CYP2E1

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Cytochrome P450 2E1
MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL
AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP
TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI
ADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA
EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG
TETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRF
ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK
FKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGC
IPPRYKLCVIPRS

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
493

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
56850

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
8.22

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Macromolecular_Interacting_Partner_3_Specific_Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites

# Macromolecular_Interacting_Partner_3_Pathway:
map00071  Fatty acid metabolism;
 map00361  gamma-Hexachlorocyclohexane degradation;
 map00380  Tryptophan metabolism

# Macromolecular_Interacting_Partner_3_Reaction:
RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00067:p450

# Macromolecular_Interacting_Partner_3_Signals:
1-28

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
EC 1.14.14.1

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
181360

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
CP2E1_HUMAN (P05181)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
CYP2E1

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
CYP2E1

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:2631

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1482 bp
ATGTCTGCCCTCGGAGTGACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTGGTG
TCCATGTGGAGGCAGGTGCACAGCAGCTGGAATCTGCCCCCAGGTCCTTTCCCGCTTCCC
ATCATCGGGAACCTCTTCCAGTTGGAATTGAAGAATATTCCCAAGTCCTTCACCCGGTTG
GCCCAGCGCTTCGGGCCGGTGTTCACGCTGTACGTGGGCTCGCAGCGCATGGTGGTGATG
CACGGCTACAAGGCGGTGAAGGAAGCGCTGCTGGACTACAAGGACGAGTTCTCGGGCAGA
GGCGACCTCCCCGCGTTCCATGCGCACAGGGACAGGGGAATCATTTTTAATAATGGACCT
ACCTGGAAGGACATCCGGCGGTTTTCCCTGACCACCCTCCGGAACTATGGGATGGGGAAA
CAGGGCAATGAGAGCCGGATCCAGAGGGAGGCCCACTTCCTGCTGGAAGCACTCAGGAAG
ACCCAAGGCCAGCCTTTCGACCCCACCTTCCTCATCGGCTGCGCGCCCTGCAACGTCATA
GCCGACATCCTCTTCCGCAAGCATTTTGACTACAATGATGAGAAGTTTCTAAGGCTGATG
TATTTGTTTAATGAGAACTTCCACCTACTCAGCACTCCCTGGCTCCAGCTTTACAATAAT
TTTCCCAGCTTTCTACACTACTTGCCTGGAAGCCACAGAAAAGTCATAAAAAATGTGGCT
GAAGTAAAAGAGTATGTGTCTGAAAGGGTGAAGGAGCACCATCAATCTCTGGACCCCAAC
TGTCCCCGGGACCTCACCGACTGCCTGCTCGTGGAAATGGAGAAGGAAAAGCACAGTGCA
GAGCGCTTGTACACAATGGACGGTATCACCGTGACTGTGGCCGACCTGTTCTTTGCGGGG
ACAGAGACCACCAGCACAACTCTGAGATATGGGCTCCTGATTCTCATGAAATACCCTGAG
ATCGAAGAGAAGCTCCATGAAGAAATTGACAGGGTGATTGGGCCAAGCCGAATCCCTGCC
ATCAAGGATAGGCAAGAGATGCCCTACATGGATGCTGTGGTGCATGAGATTCAGCGGTTC
ATCACCCTCGTGCCCTCCAACCTGCCCCATGAAGCAACCCGAGACACCATTTTCAGAGGA
TACCTCATCCCCAAGGGCACAGTCGTAGTGCCAACTCTGGACTCTGTTTTGTATGACAAC
CAAGAATTTCCTGATCCAGAAAAGTTTAAGCCAGAACACTTCCTGAATGAAAATGGAAAG
TTCAAGTACAGTGACTATTTCAAGCCATTTTCCACAGGAAAACGAGTGTGTGCTGGAGAA
GGCCTGGCTCGCATGGAGTTGTTTCTTTTGTTGTGTGCCATTTTGCAGCATTTTAATTTG
AAGCCTCTCGTTGACCCAAAGGATATCGACCTCAGCCCTATACATATTGGGTTTGGCTGT
ATCCCACCACGTTACAAACTCTGTGTCATTCCCCGCTCATGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
J02625

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_3_Locus:
10q24.3-qter

# Macromolecular_Interacting_Partner_3_SNPs:
rs6413419; rs28969387; rs915909; rs2515641; rs28371746; rs7081484; rs2480257; rs2480256; rs11101812; rs11445593; rs12164704; rs915908; rs2480259; rs943975; rs2070677; rs915907; rs2249694; rs743534; rs1410897; rs2070676; rs1536828; rs2515642; rs2249695; rs2480258; rs7088600; rs743535; rs2864984; rs915906; rs1329149; rs2070675; rs6413432; rs943976; rs4646976; rs6413421; rs41258504; rs8192777; rs2902902; rs8192770; rs2070674; rs28969386; rs9919378; rs2864986; rs2011661; rs2864987; rs11819675; rs28371747; rs2864985; rs2771202; rs7092584; rs8192775; rs8192772; rs12164778; rs41299400; rs11818144; rs6413439; rs9919379; rs41299436; rs9919386; rs12257054; rs41299420; rs8192776; rs2854144; rs12254222; rs28371748; rs41299414; rs9629960; rs12254225; rs41299422; rs6413440; rs41299410; rs8192769; rs28371745; rs28371742; rs41299428; rs7088325; rs41299430; rs41299418; rs8192773; rs9629959; rs12761234; rs2515644; rs2031920; rs3813865; rs2031921; rs3813867; rs6413423; rs2031922; rs6413424; rs8192766; rs6413420; rs2070673; rs10857739; rs2070672; rs7092804; rs35806299; rs34808295; rs7082229; rs2480255; rs2480254; rs3813866; rs6413422; rs34562297; rs35844228; rs41299426; rs41299434; rs34767794; rs28371740; rs28371743; rs35748520; rs28371741; rs8192768; rs28517390; rs11368724; rs11417006; rs28371739; rs35353214; rs12762259; rs28594404; rs41299402; rs10552252; rs2854146; rs41299438; rs3065552; rs41299440; rs28371744; rs12766531; rs41299432; rs8192767; rs41299404; rs2854145; rs2771203; rs28437930; rs5789170; rs41299406; rs11460955; rs41299412; rs12767308; rs10698404; rs41299416; rs28613531; rs8192771; rs41299424; rs41299408; rs41283307; rs7342118; rs9419083; rs2854143; rs41299398; rs34625023; rs2854142; rs12164715; rs2515643; rs35467185; rs2854140; rs11516897; rs11575870; rs12164716; rs3813870; rs12164799; rs2854141; rs10776686; rs10776687; rs10857733; rs10857736; rs10857741; rs11101803; rs11101806; rs11101815; rs11516898; rs11527823; rs11527824; rs11812957; rs12260065; rs12266332; rs12267919; rs12269057; rs12359703; rs1536826; rs1952467; rs2031919; rs4240522; rs4512750; rs4838689; rs4838767; rs4838768; rs7091961; rs7893521; rs8192780; rs8192781; rs9418989; rs9418990; rs9419081; rs9419082; rs9629923; rs9629926; rs9629928; rs9629962; rs9629963; rs9629964; rs9629971; rs9629973; rs9629975; rs9629976; rs9629977; rs9629981; rs9629982; rs9629983

# Macromolecular_Interacting_Partner_3_General_References:
3782137; 3233219; 3675576; 2587619; 8031147; 9058590; 9918138

# Macromolecular_Interacting_Partner_3_References:
12427108; 10667633; 10801323

# Macromolecular_Interacting_Partner_4_ID:
7087

# Macromolecular_Interacting_Partner_4_Name:
Calcium-activated potassium channel subunit alpha 1

# Macromolecular_Interacting_Partner_4_Synonyms:
Calcium-activated potassium channel, subfamily M subunit alpha 1; Maxi K channel; MaxiK; BK channel; K(VCAalpha; BKCA alpha; KCa1.1; Slowpoke homolog; Slo homolog; Slo-alpha; Slo1; hSlo

# Macromolecular_Interacting_Partner_4_Gene_Name:
KCNMA1

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Calciumactivated potassium channel subunit alpha 1
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS
VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH
CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL
WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL
VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA
KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES
VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK
IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW
NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE
MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLG
FFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRPKMSIYKRMRRACCFDCGRSERD
CSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPN
TSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSG
HVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVS
ILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIG
VLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDD
DPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEEN
ALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRL
RDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSS
KKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
1236

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
137561

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
7.07

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  transporter activity
Function:  ion transporter activity
Function:  ion channel activity
Function:  cation channel activity
Function:  potassium channel activity
Function:  calcium-activated potassium channel activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  cation transport
Process:  monovalent inorganic cation transport
Process:  potassium ion transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_4_Specific_Function:
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX)

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF03493:BK_channel_a;
PF00520:Ion_trans

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
87-107
179-199
215-235
240-260
265-285
301-321
368-388

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
537439

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
KCMA1_HUMAN (Q12791)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
KCNMA1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
KCNMA1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:6284

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>3537 bp
ATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGC
AGCAGTCTTAGAATGAGTAGCAATATCCACGCGAACCATCTCAGCCTAGACGTGTCCTCC
TCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCG
GTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGAC
AGCCGGGGCCAACGCATGTGGTGGGCTTTCCTGGCCTCCTCCATGGTGACTTTCTTCGGG
GGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCAC
TGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGC
ACTCTCAAACCAGTGGATGAAAAAGAGGAGGCAGTGGCCGCCGAGGTCGGCTGGATGACC
TCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTG
GTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCA
AACCCAATAGAATCCTGCCAGAATTTCTACAAAGATTTCACATTACAGATCGACATGGCT
TTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTG
TGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTG
TCTGTGTACTTAAACAGAAGTTGGCTTGGTTTGAGATTTTTAAGAGCTCTGAGACTGATA
CAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGTAATTCCATCAAGCTG
GTGAATCTGCTCTCCATATTTATCAGCACGTGGCTGACTGCAGCCGGGTTCATCCATTTG
GTGGAGAATTCAGGGGACCCATGGGAAAATTTCCAAAACAACCAGGCTCTCACCTACTGG
GAATGTGTCTATTTACTCATGGTCACAATGTCCACCGTTGGTTATGGGGATGTTTATGCA
AAAACCACACTTGGGCGCCTCTTCATGGTCTTCTTCATCCTCGGGGGACTGGCCATGTTT
GCCAGCTACGTCCCTGAAATCATAGAGTTAATAGGAAACCGCAAGAAATACGGGGGCTCC
TATAGTGCGGTTAGTGGAAGAAAGCACATTGTGGTCTGCGGACACATCACTCTGGAGAGT
GTTTCCAACTTCCTGAAGGACTTTCTGCACAAGGACCGGGATGACGTCAATGTGGAGATC
GTTTTTCTTCACAACATCTCCCCCAACCTGGAGCTTGAAGCTCTGTTCAAACGACATTTT
ACTCAGGTGGAATTTTATCAGGGTTCCGTCCTCAATCCACATGATCTTGCAAGAGTCAAG
ATAGAGTCAGCAGATGCATGCCTGATCCTTGCCAACAAGTACTGCGCTGACCCGGATGCG
GAGGATGCCTCGAATATCATGAGAGTAATCTCCATAAAGAACTACCATCCGAAGATAAGA
ATCATCACTCAAATGCTGCAGTATCACAACAAGGCCCATCTGCTAAACATCCCGAGCTGG
AATTGGAAAGAAGGTGATGACGCAATCTGCCTCGCAGAGTTGAAGTTGGGCTTCATAGCC
CAGAGCTGCCTGGCTCAAGGCCTCTCCACCATGCTTGCCAACCTCTTCTCCATGAGGTCA
TTCATAAAGATTGAGGAAGACACATGGCAGAAATACTACTTGGAAGGAGTCTCAAATGAA
ATGTACACAGAATATCTCTCCAGTGCCTTCGTGGGTCTGTCCTTCCCTACTGTTTGTGAG
CTGTGTTTTGTGAAGCTCAAGCTCCTAATGATAGCCATTGAGTACAAGTCTGCCAACCGA
GAGAGCCGTATATTAATTAATCCTGGAAACCATCTTAAGATCCAAGAAGGTACTTTAGGA
TTTTTCATCGCAAGTGATGCCAAAGAAGTTAAAAGGGCATTTTTTTACTGCAAGGCCTGT
CATGATGACATCACAGATCCCAAAAGAATAAAAAAATGTGGCTGCAAACGGCTTGAAGAT
GAGCAGCCGTCAACACTATCACCAAAAAAAAAGCAACGGAATGGAGGCATGCGGAACTCA
CCCAACACCTCGCCTAAGCTGATGAGGCATGACCCCTTGTTAATTCCTGGCAATGATCAG
ATTGACAACATGGACTCCAATGTGAAGAAGTACGACTCTACTGGGATGTTTCACTGGTGT
GCACCCAAGGAGATAGAGAAAGTCATCCTGACTCGAAGTGAAGCTGCCATGACCGTCCTG
AGTGGCCATGTCGTGGTCTGCATCTTTGGCGACGTCAGCTCAGCCCTGATCGGCCTCCGG
AACCTGGTGATGCCGCTCCGTGCCAGCAACTTTCATTACCATGAGCTCAAGCACATTGTG
TTTGTGGGCTCTATTGAGTACCTCAAGCGGGAATGGGAGACGCTTCATAACTTCCCCAAA
GTGTCCATATTGCCTGGTACGCCATTAAGTCGGGCTGATTTAAGGGCTGTCAACATCAAC
CTCTGTGACATGTGCGTTATCCTGTCAGCCAATCAGAATAATATTGATGATACTTCGCTG
CAGGACAAGGAATGCATCTTGGCGTCACTCAACATCAAATCTATGCAGTTTGATGACAGC
ATCGGAGTCTTGCAGGCTAATTCCCAAGGGTTCACACCTCCAGGAATGGATAGATCCTCT
CCAGATAACAGCCCAGTGCACGGGATGTTACGTCAACCATCCATCACAACTGGGGTCAAC
ATCCCCATCATCACTGAACTAGTGAACGATACTAATGTTCAGTTTTTGGACCAAGACGAT
GATGATGACCCTGATACAGAACTGTACCTCACGCAGCCCTTTGCCTGTGGGACAGCATTT
GCCGTCAGTGTCCTGGACTCACTCATGAGCGCGACGTACTTCAATGACAATATCCTCACC
CTGATACGGACCCTGGTGACCGGAGGAGCCACGCCGGAGCTGGAGGCTCTGATTGCTGAG
GAAAACGCCCTTAGAGGTGGCTACAGCACCCCGCAGACACTGGCCAATAGGGACCGCTGC
CGCGTGGCCCAGTTAGCTCTGCTCGATGGGCCATTTGCGGACTTAGGGGATGGTGGTTGT
TATGGTGATCTGTTCTGCAAAGCTCTGAAAACATATAATATGCTTTGTTTTGGAATTTAC
CGGCTGAGAGATGCTCACCTCAGCACCCCCAGTCAGTGCACAAAGAGGTATGTCATCACC
AACCCGCCCTATGAGTTTGAGCTCGTGCCGACGGACCTGATCTTCTGCTTAATGCAGTTT
GACCACAATGCCGGCCAGTCCCGGGCCAGCCTGTCCCATTCCTCCCACTCGTCGCAGTCC
TCCAGCAAGAAGAGCTCCTCTGTTCACTCCATCCCATCCACAGCAAACCGACAGAACCGG
CCCAAGTCCAGGGAGTCCCGGGACAAACAGAAGTACGTGCAGGAAGAGCGGCTTTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
U13913

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_4_Locus:
10q22.3

# Macromolecular_Interacting_Partner_4_SNPs:
rs1131824; rs4980113; rs7073015; rs7894833; rs6480840; rs2116830; rs10762733; rs10762732; rs10824460; rs1897594; rs10824462; rs11001914; rs7078702; rs7070085; rs11001915; rs674840; rs816828; rs560830; rs1866591; rs35787; rs35793; rs489865; rs570706; rs42455; rs717207; rs598651; rs35776; rs816864; rs2290712; rs1871064; rs1897590; rs1907746; rs2616612; rs673195; rs866864; rs1850285; rs1907724; rs548216; rs660465; rs1268510; rs603788; rs572093; rs596832; rs2249945; rs1457524; rs667808; rs2670149; rs1473966; rs1436092; rs2619638; rs35807; rs1369809; rs1907727; rs1516514; rs2673475; rs1871065; rs554834; rs176287; rs2176283; rs1318421; rs2925826; rs40430; rs624713; rs1877993; rs2619610; rs999993; rs2280163; rs2077641; rs595386; rs1247755; rs479033; rs816839; rs605089; rs1926702; rs688528; rs999995; rs1247763; rs527458; rs2163799; rs1247769; rs637897; rs1561087; rs1436089; rs207675; rs2288836; rs734949; rs176285; rs938519; rs2673418; rs2673471; rs994076; rs593572; rs2673462; rs2720001; rs592676; rs35774; rs1897592; rs611519; rs2917454; rs287184; rs577360; rs539954; rs501254; rs2766620; rs1516505; rs582273; rs35790; rs1457523; rs2719995; rs583507; rs184090; rs2574797; rs696211; rs185944; rs1516513; rs623257; rs189745; rs2247557; rs672735; rs660940; rs2673436; rs1248571; rs655487; rs861662; rs585895; rs591485; rs28735; rs938225; rs480177; rs1873696; rs610097; rs1907722; rs872794; rs2119058; rs880864; rs2670147; rs2619627; rs1907720; rs1247767; rs2395463; rs2253545; rs637847; rs2670164; rs2116829; rs250710; rs627203; rs1873692; rs2574796; rs2288839; rs1907725; rs42311; rs1865020; rs555766; rs1813767; rs1248572; rs2766625; rs523611; rs2719978; rs866865; rs1457525; rs2673429; rs584141; rs1457526; rs1356255; rs1247771; rs2719979; rs1991808; rs547144; rs166994; rs287187; rs2928137; rs10824520; rs1949352; rs7921994; rs3844118; rs586676; rs1659789; rs502708; rs7097408; rs7922645; rs1400253; rs7076995; rs1515404; rs1974059; rs603146; rs625148; rs582449; rs11597111; rs2616651; rs10740467; rs10762744; rs2116832; rs10762756; rs2619628; rs7083476; rs540783; rs7909999; rs10824515; rs2670108; rs652373; rs10762741; rs6480857; rs7924171; rs1247781; rs3781156; rs681088; rs4639876; rs289274; rs7071891; rs752372; rs6480855; rs1439785; rs612797; rs1516507; rs2037193; rs1247787; rs7071840; rs2026591; rs10824541; rs703265; rs1247784; rs10824534; rs7073856; rs7076580; rs250708; rs7095155; rs1907716; rs10740466; rs1248568; rs2766618; rs6480847; rs2670137; rs2616654; rs503242; rs35777; rs816848; rs843836; rs7898846; rs10762745; rs7900755; rs11001998; rs7068994; rs176286; rs3127449; rs697168; rs287170; rs11002086; rs866539; rs10824512; rs11002137; rs11001950; rs816850; rs7897924; rs7086095; rs1247774; rs2395453; rs2574790; rs7903765; rs3910605; rs4633404; rs603674; rs10762753; rs6480856; rs1897593; rs7097255; rs1897591; rs11593691; rs7896256; rs35780; rs1400250; rs2619634; rs10824544; rs1873695; rs487926; rs1907723; rs11818892; rs287174; rs1567999; rs874564; rs7072185; rs3851038; rs6480861; rs1079026; rs1247756; rs7895108; rs2719998; rs993609; rs2255649; rs600557; rs11001996; rs4979873; rs2670121; rs7918140; rs669540; rs3851040; rs6480848; rs1866587; rs2003194; rs1248567; rs7910544; rs980832; rs4979884; rs1903896; rs2619642; rs653253; rs7895934; rs7067779; rs1515416; rs1464138; rs6480850; rs7897426; rs1907714; rs6480859; rs10740464; rs2119059; rs10740460; rs2288840; rs625587; rs2619624; rs1247778; rs7097101; rs669677; rs10824508; rs994075; rs289265; rs2574805; rs7916611; rs11001918; rs1501637; rs10824540; rs703260; rs1873691; rs10824475; rs621093; rs1907726; rs2673488; rs2395501; rs4980118; rs1400251; rs2246635; rs10762759; rs7907270; rs2131217; rs2131218; rs4979892; rs2673427; rs2673428; rs2574784; rs2199582; rs10824478; rs2163796; rs1516510; rs6480842; rs7080575; rs7918564; rs11001968; rs7923581; rs12775139; rs7089123; rs561336; rs7071575; rs10762743; rs1318644; rs2253530; rs10762757; rs2670117; rs2574804; rs3781142; rs1907744; rs669509; rs7904387; rs1004585; rs10509383; rs2253072; rs10824545; rs2574793; rs556172; rs3862499; rs10824524; rs10824532; rs7076990; rs7086316; rs10762734; rs816849; rs816843; rs10762755; rs1247759; rs2116831; rs816867; rs7088086; rs2619625; rs494557; rs1878001; rs938517; rs287177; rs1865018; rs7083934; rs1907747; rs1247770; rs12411508; rs4980123; rs1907730; rs1873693; rs7099467; rs1871063; rs670898; rs7082883; rs1516512; rs3781157; rs959796; rs1877578; rs7912269; rs1907740; rs10824521; rs10437395; rs2574799; rs11001919; rs3844120; rs1907718; rs2619612; rs11001973; rs7907504; rs536297; rs1903894; rs1865017; rs816852; rs1907715; rs2244338; rs3127447; rs573712; rs10824477; rs2255656; rs4980144; rs2619640; rs10824466; rs3887429; rs2253201; rs7905358; rs4980117; rs10824549; rs10509386; rs676267; rs4980146; rs3781153; rs250706; rs12359379; rs936319; rs3902277; rs10762760; rs3781141; rs7079556; rs7915877; rs11598926; rs7087337; rs12775320; rs7094815; rs12770151; rs11814850; rs2574803; rs10824522; rs1543588; rs1473965; rs11002079; rs7070554; rs2619617; rs473881; rs520887; rs655797; rs816827; rs10824537; rs181836; rs7898951; rs11002089; rs1897586; rs35806; rs4980150; rs11002104; rs11002208; rs12764328; rs607483; rs2925827; rs1866593; rs2250972; rs655455; rs499437; rs646678; rs11002109; rs1878216; rs1464111; rs816838; rs618081; rs10762749; rs682275; rs7068356; rs6480844; rs584021; rs567857; rs673657; rs172291; rs607459; rs1878002; rs2131216; rs1106657; rs9633596; rs2670107; rs10824527; rs1436091; rs617963; rs1319039; rs1439789; rs10824547; rs1247754; rs7906640; rs669069; rs2670165; rs602219; rs7093275; rs816855; rs17388160; rs2045448; rs7073501; rs7069801; rs11002123; rs2619641; rs12571330; rs860990; rs12415149; rs2616648; rs2253202; rs11002064; rs10824519; rs16934860; rs4622198; rs12413675; rs287190; rs11599090; rs521773; rs35782; rs12248514; rs3937866; rs7093023; rs816845; rs12569535; rs1873694; rs10824496; rs3910604; rs2619608; rs1247766; rs10824494; rs4980126; rs11002041; rs7912940; rs2163798; rs12218239; rs17391134; rs35772; rs10509381; rs2673465; rs583264; rs2673434; rs10824483; rs488900; rs816868; rs16934131; rs10824467; rs11001993; rs2673401; rs10509385; rs16935090; rs626860; rs2574789; rs16934472; rs11001978; rs10509387; rs11002092; rs1907734; rs16934760; rs2164443; rs12248504; rs1247777; rs816853; rs10762752; rs558649; rs7069982; rs35794; rs609753; rs7907070; rs675055; rs7071160; rs11813909; rs10509378; rs10509384; rs10824484; rs16933980; rs547039; rs7923681; rs35792; rs11002088; rs11002078; rs7922373; rs11816403; rs2607801; rs7093668; rs1907732; rs12782599; rs4979880; rs2163795; rs1436090; rs11594398; rs625997; rs11814189; rs10762739; rs16934296; rs2045449; rs11002162; rs1371457; rs2253060; rs586182; rs10824536; rs11002091; rs11001971; rs2719996; rs11001992; rs7922088; rs12573582; rs7095476; rs3781167; rs35788; rs563994; rs2619629; rs2280165; rs12778094; rs2673461; rs10824526; rs17480656; rs612732; rs7071593; rs11001997; rs11002200; rs558828; rs2169673; rs12254500; rs12765834; rs10740461; rs11002057; rs790; rs1248563; rs566319; rs561861; rs17390995; rs2255727; rs12217811; rs12265896; rs10762742; rs10824510; rs2616650; rs28286; rs12263942; rs866392; rs1907745; rs287173; rs4980145; rs4980136; rs2673466; rs11001947; rs7098001; rs2720010; rs1907741; rs1247785; rs11593685; rs2574798; rs16934688; rs672746; rs542007; rs11002149; rs11002099; rs2619609; rs250709; rs11591437; rs35796; rs10824495; rs12768649; rs287175; rs1356278; rs11597359; rs1850286; rs7095075; rs12416677; rs7906219; rs7086619; rs11001987; rs10824525; rs865292; rs10824530; rs3781158; rs11001975; rs2116833; rs2619620; rs10824493; rs816861; rs7079351; rs2673454; rs479256; rs620803; rs10762738; rs2670128; rs2670166; rs2673487; rs3781139; rs16934781; rs1907733; rs39684; rs1926698; rs11002051; rs1516506; rs3844119; rs477375; rs513489; rs158205; rs1347543; rs2616653; rs11002056; rs17412609; rs994594; rs12217851; rs1271394; rs16933997; rs2395442; rs1897589; rs2395500; rs7919150; rs7903624; rs17415304; rs816837; rs1247757; rs4980128; rs3862501; rs1247761; rs519476; rs1907719; rs1878217; rs7097325; rs10824481; rs1871066; rs10824492; rs12255547; rs12415834; rs1907731; rs2619626; rs7897566; rs16934331; rs17389253; rs287172; rs207676; rs2209666; rs10762758; rs11596101; rs11812342; rs3824716; rs11002211; rs12411341; rs35791; rs12774512; rs2288837; rs3816025; rs7898958; rs1028831; rs43204; rs11595074; rs956513; rs16934182; rs17389791; rs714673; rs16934801; rs2574810; rs7893394; rs502004; rs3844123; rs7087190; rs2619613; rs2619618; rs1907717; rs10824474; rs3781166; rs7908126; rs7071433; rs10509390; rs7914901; rs1079037; rs10437394; rs11002201; rs10509380; rs7922300; rs3851037; rs35781; rs2082415; rs10824516; rs11597938; rs10824487; rs11813473; rs11598241; rs7086746; rs1871062; rs7078013; rs2673476; rs12219105; rs1247764; rs7912978; rs7897756; rs2616652; rs2172305; rs9943331; rs613364; rs12416539; rs7923107; rs10824465; rs1457522; rs669657; rs2619631; rs2250840; rs11001957; rs11815742; rs10824479; rs16934917; rs16934600; rs2574787; rs250712; rs10762754; rs617142; rs816841; rs11001976; rs7078109; rs529426; rs583728; rs860129; rs11593384; rs816857; rs12772410; rs16934349; rs2616646; rs10509389; rs664470; rs11002110; rs11002020; rs3887173; rs7906642; rs11002117; rs11592934; rs1516509; rs11594152; rs11818009; rs1476318; rs11592060; rs3781140; rs7070015; rs11595722; rs4979882; rs2247880; rs816847; rs4980147; rs585620; rs10159939; rs7907577; rs17413503; rs7910422; rs169661; rs16934833; rs35795; rs2574802; rs2574794; rs158206; rs10824514; rs7071842; rs10824489; rs11001999; rs10824509; rs7906441; rs40432; rs7923095; rs16934799; rs7906039; rs2766628; rs1878218; rs11596872; rs2250841; rs1247762; rs10740463; rs16934883; rs3781160; rs10824542; rs35799; rs2243681; rs6480853; rs1247776; rs10824473; rs11002059; rs7912055; rs7918859; rs1976717; rs2616655; rs2673417; rs475585; rs1457521; rs35798; rs2288838; rs686374; rs10824517; rs860989; rs3781150; rs2217895; rs10824546; rs11594783; rs1439788; rs10824552; rs2131215; rs1356092; rs1598793; rs553199; rs1247783; rs12359688; rs35773; rs10824523; rs1866594; rs11002139; rs152774; rs2616611; rs10824482; rs250711; rs11001989; rs7922568; rs7910205; rs607769; rs11001952; rs1711290; rs11002133; rs42453; rs7087345; rs10762751; rs11002222; rs2766624; rs816840; rs3781164; rs16934172; rs625737; rs4979881; rs2619632; rs2607798; rs12219498; rs11002120; rs11593194; rs1369808; rs2673489; rs35778; rs880863; rs12220179; rs12220505; rs10824535; rs287196; rs11002054; rs10509382; rs7922961; rs10824518; rs6480843; rs1439787; rs11816507; rs10509379; rs2673437; rs1968013; rs11593652; rs158421; rs7099352; rs3125429; rs11001956; rs656283; rs7905555; rs703266; rs10824490; rs1907721; rs7072406; rs11817355; rs1555924; rs11596909; rs816846; rs866419; rs287186; rs12572857; rs2719981; rs10824497; rs250707; rs980833; rs11002044; rs580986; rs182296; rs11595443; rs816854; rs4378328; rs16934766; rs1261988; rs10762740; rs7895375; rs536430; rs11002224; rs864026; rs2720007; rs2616645; rs7894324; rs16934560; rs16934354; rs816863; rs10509388; rs10824538; rs993476; rs11002158; rs2670118; rs11002116; rs551010; rs11002065; rs6480858; rs11594665; rs2258870; rs4980120; rs2670136; rs12250255; rs2619611; rs190380; rs1356256; rs11002126; rs11592554; rs7475710; rs39685; rs12253173; rs10824543; rs628948; rs7893614; rs17480887; rs1907728; rs816856; rs2395480; rs11001970; rs2280164; rs2673402; rs7098061; rs3781168; rs509722; rs7078632; rs16935144; rs658038; rs3110032; rs11002097; rs2766619; rs11002159; rs10824463; rs7089425; rs846101; rs745402; rs843835; rs11596838; rs7913206; rs4980137; rs12761271; rs816831; rs12358397; rs11002087; rs2448395; rs10160069; rs12780411; rs1247768; rs11002184; rs287179; rs678816; rs10762761; rs7918148; rs3900539; rs12218822; rs11592698; rs16934828; rs1948746; rs11814245; rs547163; rs12767900; rs12355027; rs12218026; rs12355548; rs559360; rs1865019; rs10824506; rs11002223; rs2616606; rs7083950; rs816835; rs12249361; rs2395465; rs16934549; rs12257235; rs4979877; rs7923969; rs7902210; rs1865021; rs12220064; rs2607800; rs12413674; rs158209; rs3851039; rs7096548; rs817190; rs4979885; rs11001983; rs11002069; rs11002212; rs16934368; rs7916246; rs4408254; rs2395444; rs1468037; rs12572413; rs1871061; rs734883; rs7074008; rs10824502; rs7393115; rs865293; rs35779; rs7906526; rs11001988; rs16934869; rs11002062; rs7067873; rs16935161; rs1907742; rs7080200; rs11002132; rs2673406; rs17392393; rs936318; rs17388943; rs3781163; rs1247773; rs3781170; rs12220957; rs4979889; rs12253758; rs2292717; rs4399276; rs927875; rs2247887; rs12221259; rs35713528; rs12782721; rs16934208; rs17480698; rs11002206; rs2296676; rs10733906; rs7909010; rs12256436; rs7916784; rs2616640; rs2670129; rs4979890; rs12569854; rs12357970; rs16934419; rs7088034; rs12782145; rs16934960; rs4980116; rs12264331; rs10824501; rs2673425; rs12245071; rs12769127; rs11596489; rs1028832; rs10762750; rs2278399; rs2395460; rs1903895; rs7910921; rs4979876; rs7922133; rs7909099; rs11594940; rs35783; rs1515417; rs559419; rs2719980; rs11002101; rs2248277; rs16913647; rs11001961; rs7086761; rs12220262; rs158208; rs12415915; rs7092786; rs12257908; rs2616643; rs11002118; rs16935100; rs7894547; rs7923848; rs1865022; rs4980148; rs482422; rs11002022; rs11002105; rs11002042; rs11002071; rs16935102; rs3781159; rs250704; rs816830; rs11002199; rs12247001; rs2048626; rs4345908; rs12569845; rs12768731; rs16934352; rs584990; rs10824554; rs16934025; rs16935043; rs12571938; rs17506197; rs497578; rs16934328; rs11595437; rs927874; rs11002031; rs3844122; rs504374; rs12262785; rs2619619; rs11002081; rs12762512; rs7075564; rs2616635; rs11596769; rs477568; rs2670116; rs7906893; rs7080704; rs4979878; rs12359771; rs1926701; rs7920471; rs11002049; rs10824507; rs11002169; rs477597; rs10824504; rs11002194; rs2720005; rs16934797; rs12262798; rs11002156; rs7087474; rs7903931; rs11002125; rs1247782; rs12241296; rs3862502; rs7895756; rs11002068; rs16934345; rs1568000; rs7897450; rs6480845; rs7911878; rs2719983; rs9943330; rs17503831; rs40142; rs12774382; rs7097332; rs16934809; rs11002015; rs1865016; rs12771023; rs7088376; rs11001965; rs11593013; rs12241006; rs287202; rs12220157; rs16934764; rs7098832; rs2247697; rs533584; rs3781171; rs2131220; rs17486753; rs10762746; rs7069503; rs11002014; rs7909335; rs3802645; rs2619639; rs12251114; rs11002032; rs4980119; rs12258392; rs7076675; rs4979897; rs7076474; rs10824533; rs11002122; rs11001958; rs2574795; rs12240791; rs2574791; rs7091243; rs2574807; rs3781143; rs16934441; rs7895631; rs11597431; rs683088; rs11002072; rs11002061; rs7910627; rs3862503; rs16934032; rs11001979; rs2067186; rs7083771; rs169602; rs12266321; rs2574786; rs1356091; rs35808; rs16934000; rs11002011; rs1850287; rs2247743; rs10824503; rs2673457; rs11814127; rs571396; rs2766622; rs17480203; rs11002131; rs10824468; rs4980141; rs3127448; rs12248157; rs17480264; rs11002144; rs11001933; rs11598499; rs4980127; rs816842; rs16934089; rs10740465; rs734884; rs11001969; rs816869; rs647778; rs11002005; rs2574785; rs11002136; rs2619630; rs7911383; rs12573143; rs12252174; rs2395462; rs12359742; rs2014471; rs2619635; rs11002145; rs16934856; rs7075164; rs6480846; rs287178; rs11814217; rs7070122; rs12243777; rs4979874; rs2452333; rs2116827; rs12355116; rs2616609; rs3781161; rs11002058; rs2673416; rs17480173; rs16934396; rs7476396; rs1247758; rs7915443; rs2246003; rs11001972; rs4979893; rs7912528; rs10824557; rs7921324; rs11001985; rs12768824; rs11002198; rs16934683; rs12414555; rs620354; rs12240507; rs11594350; rs12766265; rs16935108; rs10824529; rs11001967; rs1078740; rs583510; rs12782077; rs7076508; rs11815718; rs817528; rs11002179; rs11002121; rs2673455; rs4979888; rs550303; rs16934403; rs860162; rs11002085; rs3844121; rs12219334; rs10824511; rs12572402; rs816851; rs16934318; rs10824499; rs2720009; rs745363; rs17388908; rs11002070; rs817672; rs17415098; rs12243157; rs35789; rs16934873; rs1371458; rs4980122; rs2616642; rs1247775; rs11002043; rs2395452; rs11002157; rs3127450; rs816866; rs3910606; rs11002075; rs169601; rs816833; rs2117910; rs2048627; rs2203604; rs624213; rs11002154; rs2670115; rs579143; rs2574808; rs2278400; rs2719982; rs16934248; rs12240864; rs7893843; rs2607799; rs11599757; rs17478773; rs2116826; rs11596612; rs1248566; rs10824548; rs1659784; rs7070378; rs16934646; rs35809; rs7894053; rs7900261; rs1356090; rs12569574; rs16934440; rs11002013; rs11002153; rs2607802; rs11002035; rs9988712; rs527706; rs16934543; rs11001986; rs651299; rs11001963; rs816836; rs2766623; rs7913421; rs40431; rs11002130; rs11001944; rs7909237; rs12769218; rs17479797; rs11002066; rs816862; rs10824539; rs2619615; rs7917550; rs16933996; rs2448394; rs999994; rs2395479; rs628992; rs504197; rs3781147; rs16934772; rs16934305; rs1247786; rs16934690; rs3851041; rs10824531; rs10762737; rs7909588; rs12416554; rs7909390; rs1865023; rs12781774; rs16934206; rs11813660; rs1122877; rs12415727; rs673831; rs479495; rs12783818; rs2169671; rs10762748; rs11002047; rs16935116; rs560305; rs10824498; rs7095163; rs250705; rs2673463; rs12241413; rs637844; rs580784; rs605976; rs287171; rs2274416; rs12359374; rs11001940; rs10824528; rs1836791; rs11002142; rs17486941; rs11002210; rs4979886; rs7894156; rs11001960; rs17484282; rs2574806; rs2395464; rs2720003; rs16934369; rs11592797; rs7912448; rs12245811; rs2673433; rs16934807; rs664053; rs16934716; rs1907737; rs11594156; rs12416271; rs11002036; rs11002007; rs7095028; rs12414292; rs816829; rs10824500; rs752762; rs11596579; rs12412773; rs12360032; rs2574788; rs12264715; rs12768125; rs2616649; rs16934836; rs7910089; rs11002074; rs11598189; rs2292718; rs11001980; rs11002127; rs11002197; rs3862500; rs816832; rs511084; rs17506456; rs12260114; rs10450308; rs17486851; rs10824488; rs12357804; rs17407165; rs7071425; rs2616641; rs2673477; rs12146201; rs16934736; rs659111; rs4979887; rs1962880; rs674444; rs10824491; rs745364; rs11002033; rs11593851; rs17507165; rs7922919; rs16934601; rs11001922; rs12780549; rs40339; rs7919397; rs7918361; rs12773252; rs158207; rs16933987; rs16933995; rs16934541; rs12357899; rs12354965; rs16934803; rs16935035; rs11597477; rs11002175; rs11002172; rs17483623; rs10762747; rs7909158; rs562187; rs17388978; rs11002219; rs16934995; rs12763167; rs11594764; rs2255725; rs11002181; rs569312; rs16934848; rs10824505; rs17413447; rs1907729; rs11002163; rs11002124; rs11592881; rs17482756; rs16934250; rs17482943; rs10762736; rs2099330; rs682126; rs2131219; rs12218554; rs12218921; rs16934534; rs11002008; rs4979875; rs11817503; rs7910590; rs2619607; rs1907743; rs17505491; rs11002166; rs1247765; rs7078525; rs12253512; rs7093735; rs4979899; rs12767350; rs572215; rs11002205; rs16934082; rs669312; rs2296677; rs10824556; rs11002034; rs502308; rs12243061; rs1849909; rs4639877; rs12783257; rs11597825; rs10465982; rs7085580; rs2673409; rs11002021; rs7920959; rs2574809; rs2395445; rs11595837; rs16934727; rs11002063; rs11001990; rs16934916; rs1516508; rs2894347; rs2894346; rs2673485; rs10824459; rs11001912; rs11598583; rs2812420; rs3192023; rs7921386; rs41274568; rs2229009; rs1051636; rs11001913; rs12783723; rs11398145; rs35661468; rs12783747; rs34440192; rs41281552; rs12761010; rs35162611; rs41281550; rs7908954; rs35698004; rs12783748; rs41281548; rs35929073; rs3936407; rs11272342; rs34380726; rs35356394; rs12240477; rs12775205; rs10685087; rs34940768; rs17502509; rs11433642; rs34130741; rs12244903; rs10588746; rs35545349; rs11002112; rs7897433; rs10590750; rs12355250; rs10824472; rs34224383; rs11392217; rs35718752; rs1837440; rs35339496; rs10602893; rs250714; rs34581992; rs3998084; rs34945994; rs35305164; rs35894134; rs11002180; rs2719999; rs7072236; rs2719993; rs35159460; rs5786285; rs7090036; rs35275511; rs34471392; rs11002119; rs34650191; rs34593783; rs34674741; rs11001946; rs664841; rs35565130; rs11314829; rs11455865; rs34221398; rs7475242; rs12240531; rs507273; rs10558661; rs35283320; rs2720004; rs3910607; rs289270; rs5786295; rs11593513; rs5786274; rs10555644; rs35883503; rs35114652; rs7096201; rs35302244; rs11002203; rs12218555; rs34664075; rs531402; rs11002147; rs36033109; rs10698438; rs34129858; rs33926459; rs34766386; rs11001938; rs166992; rs11819506; rs34263729; rs34633487; rs11002006; rs11443814; rs1907738; rs12357779; rs34693013; rs35233819; rs34104918; rs34839785; rs2670146; rs34686597; rs35247681; rs11460054; rs658329; rs4114358; rs33948140; rs169603; rs36077756; rs10762735; rs34428338; rs35261541; rs35321767; rs185943; rs12771340; rs11002143; rs34026052; rs7894241; rs7084895; rs6480852; rs11287601; rs34387105; rs10658832; rs35035914; rs36072586; rs34147412; rs10740462; rs11001936; rs287194; rs34930671; rs5786266; rs11001941; rs35605244; rs4414158; rs36008118; rs2619633; rs34122156; rs9299540; rs35097922; rs7081398; rs6143996; rs3837323; rs11002170; rs723201; rs5741701; rs12259554; rs3948354; rs11002173; rs1836792; rs7901616; rs11002217; rs11599430; rs7087619; rs4604816; rs7069006; rs3068755; rs34501369; rs11001994; rs12262582; rs34888467; rs16934371; rs816834; rs35968992; rs28706743; rs34963014; rs12783504; rs1711298; rs16934663; rs35061889; rs36100496; rs35837413; rs34118826; rs9664021; rs34793306; rs34378134; rs976068; rs11002055; rs35311171; rs11002083; rs35770; rs5786265; rs34475461; rs13377017; rs35498567; rs34057000; rs1371462; rs33971461; rs2670119; rs1052178; rs5786251; rs12762216; rs2574792; rs28654372; rs11002115; rs7895105; rs5786291; rs2574800; rs35351916; rs11001974; rs5025442; rs12257932; rs34777856; rs10701430; rs34337816; rs11002155; rs3068595; rs10637611; rs34846938; rs11002026; rs35947610; rs35292776; rs34547398; rs3071911; rs10684559; rs16934486; rs1371456; rs11002048; rs816865; rs11330368; rs35686253; rs12244239; rs34987603; rs34925903; rs5786289; rs41300548; rs34476440; rs28630563; rs10718368; rs11002148; rs5786282; rs7910574; rs35619906; rs12768378; rs12784601; rs35645218; rs12777941; rs35939073; rs34653969; rs3067677; rs34706289; rs5786279; rs39683; rs16933994; rs34785959; rs4980124; rs35208132; rs35716839; rs4980143; rs5786277; rs35234113; rs35846030; rs3998097; rs12248158; rs7902173; rs7910300; rs11402076; rs34302320; rs34595753; rs12764577; rs28542287; rs34376142; rs35056943; rs35078602; rs506555; rs16934377; rs5786256; rs10527600; rs34041020; rs11451985; rs11001984; rs11591482; rs12415943; rs3068679; rs35518349; rs11446237; rs12412336; rs35276645; rs12764511; rs3997979; rs12262583; rs35772471; rs12770192; rs35330858; rs12250818; rs35764356; rs166993; rs2117909; rs35475069; rs11594569; rs35519547; rs11369702; rs2720000; rs11594001; rs16934014; rs11001942; rs7911382; rs7081901; rs7083666; rs35438549; rs11001955; rs11002073; rs34880591; rs11002165; rs2395443; rs11456586; rs11002195; rs35554112; rs34554892; rs34941006; rs11267950; rs1561086; rs35583526; rs11002002; rs34214541; rs573048; rs35452673; rs10642805; rs1247772; rs11001966; rs2607797; rs34640561; rs35265993; rs9415158; rs3068790; rs11001920; rs11304136; rs35276091; rs34847548; rs34717545; rs7901989; rs34588382; rs938520; rs7358111; rs34782212; rs817988; rs2574811; rs34528617; rs34311272; rs11002176; rs11002039; rs4980121; rs35728303; rs11001927; rs1033986; rs34019491; rs34798894; rs35787824; rs28494548; rs287176; rs3758461; rs12264589; rs1272336; rs35621815; rs4979894; rs11002183; rs5013069; rs35517637; rs1873690; rs35180352; rs10610854; rs11597456; rs9416116; rs35993060; rs4979785; rs35254431; rs287193; rs1270877; rs35370605; rs5786284; rs11001932; rs35986879; rs12771189; rs12784630; rs35977626; rs11002095; rs35895630; rs11001982; rs5786270; rs35792348; rs12264825; rs35996461; rs12768383; rs7089214; rs11002108; rs843834; rs16933998; rs34671278; rs287197; rs10675139; rs34712581; rs12356282; rs3740246; rs34508225; rs34002562; rs11002052; rs35030342; rs11594513; rs34698220; rs34251501; rs4568953; rs3997981; rs12355753; rs10558660; rs3781148; rs1563616; rs35113519; rs1464139; rs11002135; rs12261760; rs10683085; rs12412299; rs34326001; rs11278993; rs35004109; rs34603713; rs11818484; rs10572162; rs36070481; rs183674; rs34868611; rs287185; rs11002111; rs41274570; rs34911534; rs35771; rs2134144; rs34133785; rs1265491; rs12764452; rs7912313; rs5786254; rs35303386; rs34015618; rs11593771; rs3781149; rs182299; rs34659693; rs17411944; rs41274576; rs7902571; rs816826; rs35799695; rs10631892; rs12766914; rs35688651; rs10533472; rs34713590; rs7477137; rs12771519; rs250713; rs35696557; rs34020156; rs791; rs12221446; rs11293097; rs12769118; rs2616607; rs35101718; rs35789536; rs34280075; rs34554451; rs11001959; rs12358763; rs172292; rs12262374; rs11002215; rs36007501; rs35910382; rs12784790; rs2116828; rs2766626; rs35606659; rs1926699; rs12220323; rs4980131; rs28541483; rs12774715; rs2279543; rs11002174; rs34943268; rs11002216; rs11002000; rs34193385; rs11002220; rs34246496; rs10563488; rs10710538; rs12773034; rs35362534; rs12763032; rs35960645; rs35154375; rs12773905; rs12049778; rs5786249; rs34357283; rs35873516; rs34726010; rs35383668; rs34708308; rs34934584; rs2894352; rs12764873; rs5786271; rs609349; rs34605286; rs35930787; rs10638689; rs10598733; rs34211793; rs3067711; rs34348514; rs35727882; rs5786259; rs10584189; rs36126099; rs1897585; rs2670127; rs12769697; rs3998087; rs2014183; rs481869; rs40338; rs5013389; rs12772501; rs11001937; rs3067715; rs35418260; rs34097171; rs3068748; rs17411325; rs35828758; rs34271424; rs287189; rs7069854; rs34412918; rs4980125; rs36208854; rs5786260; rs4980130; rs4625398; rs33988327; rs10715101; rs34553397; rs287192; rs35648543; rs34938613; rs34713731; rs34657957; rs35353145; rs12260404; rs12219680; rs35668958; rs5786278; rs12773532; rs4531406; rs7070171; rs34173252; rs12269169; rs547212; rs34511733; rs35078324; rs12146394; rs34802013; rs10594438; rs5786250; rs34833466; rs35829080; rs34399732; rs2673407; rs35167525; rs34543830; rs34600954; rs2148549; rs11002207; rs5786302; rs35019199; rs5786292; rs1079034; rs28712162; rs12253946; rs35626401; rs7913805; rs12241892; rs2616647; rs35786811; rs7099004; rs34481013; rs7073951; rs35637197; rs1516511; rs35167729; rs35911955; rs34061882; rs34241578; rs5002164; rs2894371; rs11002168; rs9415155; rs34629886; rs635591; rs588317; rs36069976; rs12259308; rs36096979; rs11002028; rs11002027; rs34198639; rs28571738; rs10430527; rs12775207; rs34406006; rs7918245; rs11345768; rs3997976; rs35436730; rs189747; rs34419689; rs675131; rs12783803; rs11437844; rs28430669; rs3073771; rs9415159; rs34267383; rs35086883; rs12217221; rs10578521; rs34932361; rs11448177; rs34854972; rs3071912; rs1567998; rs34827898; rs11002161; rs4980142; rs12220945; rs12774692; rs12049787; rs10522177; rs11001962; rs12357501; rs11001926; rs3068684; rs28559914; rs2574812; rs5016429; rs36079291; rs34796811; rs11002038; rs34049292; rs12779310; rs41281554; rs12764930; rs10628738; rs28700590; rs36094283; rs35799231; rs34481491; rs35698556; rs2720002; rs34269347; rs11272858; rs35785801; rs5786255; rs1968485; rs35202945; rs34392105; rs34035783; rs11596446; rs12771649; rs1907713; rs4559625; rs9943325; rs34081325; rs2117908; rs5786281; rs35637257; rs35778231; rs7904750; rs35662690; rs5786299; rs34201112; rs34119830; rs12778504; rs12764147; rs11597128; rs11288201; rs17392728; rs34378335; rs11317353; rs11001953; rs12778214; rs12782491; rs10717601; rs2126752; rs35826391; rs4980115; rs12049739; rs34701010; rs35329642; rs34863978; rs12769997; rs35879581; rs11002004; rs12240291; rs34932253; rs6143993; rs10542396; rs5786261; rs34867524; rs10696567; rs10588747; rs12413030; rs34258163; rs2117907; rs34171087; rs4275556; rs11813419; rs11814814; rs28796652; rs12220331; rs34611409; rs35964716; rs11002160; rs629966; rs12359284; rs11002067; rs35070307; rs35103280; rs11001934; rs12771435; rs35075383; rs34309056; rs12774371; rs34311772; rs2616608; rs12221028; rs35547486; rs35221640; rs9416118; rs7912270; rs2574813; rs12358532; rs11002024; rs3068600; rs11002023; rs35333567; rs35573127; rs2169672; rs34537500; rs34603278; rs34625596; rs35698225; rs36024406; rs2670120; rs4979883; rs7913952; rs35528388; rs34798114; rs33932641; rs35896634; rs35027991; rs12775824; rs7074464; rs11002221; rs35430676; rs12255556; rs11002037; rs34004473; rs11371976; rs12240989; rs11002134; rs34281291; rs7916461; rs11441996; rs287199; rs10590559; rs11002138; rs36062602; rs11375807; rs11317483; rs10580904; rs35476319; rs11002053; rs34486490; rs10663230; rs2175753; rs2616610; rs28367060; rs10563925; rs34536108; rs5786253; rs35124298; rs3887430; rs12268022; rs12764753; rs5786264; rs34009508; rs11002030; rs5786248; rs34473997; rs644788; rs11002077; rs11326515; rs11002094; rs7100919; rs11002167; rs12779089; rs34500161; rs34022069; rs11002182; rs12770084; rs34773065; rs34454247; rs34276840; rs11364479; rs34088550; rs34252688; rs533102; rs12252683; rs35330767; rs11002060; rs10536103; rs12261491; rs34624749; rs12764341; rs11002192; rs182323; rs35608395; rs35138513; rs10589344; rs34495678; rs4980139; rs5786288; rs33998103; rs35815612; rs35736592; rs5026699; rs35759389; rs34075002; rs34342603; rs34245004; rs2163797; rs34071531; rs34414928; rs185945; rs5786272; rs5786258; rs2925825; rs35526767; rs7899039; rs34844470; rs11002204; rs12779465; rs34864630; rs2954109; rs5786297; rs34012040; rs10627854; rs33934743; rs34425231; rs12764923; rs9943410; rs11001948; rs34399103; rs35257209; rs11002009; rs11001991; rs34414255; rs12241013; rs2619621; rs287201; rs12783439; rs34185387; rs34999699; rs35698351; rs11400203; rs34975316; rs7084249; rs42454; rs28459226; rs10642363; rs11001923; rs35418453; rs34220574; rs11597576; rs35908963; rs287188; rs1926700; rs34528040; rs34483086; rs34218137; rs11455926; rs34368866; rs7098075; rs11002189; rs11002103; rs11001981; rs34346786; rs34716835; rs12360121; rs11001931; rs11002050; rs12258034; rs5786268; rs35654154; rs1247779; rs35364008; rs697170; rs11595772; rs11001935; rs12240475; rs35775; rs11002128; rs7092628; rs35789388; rs3997977; rs11458300; rs4994414; rs10551405; rs1272897; rs12220344; rs36019588; rs35006771; rs10672810; rs11594298; rs2670130; rs11597522; rs34094503; rs35202046; rs287195; rs11819489; rs33922202; rs35474661; rs35951095; rs12571483; rs35639990; rs7074134; rs2673408; rs34590807; rs1907735; rs34515948; rs35092347; rs12768139; rs34307071; rs13376969; rs11002029; rs36043632; rs35742212; rs7895636; rs35824210; rs11002098; rs7088115; rs1903897; rs34280745; rs33997559; rs36062874; rs12250773; rs1897588; rs35382696; rs5786283; rs34520522; rs28394350; rs34270751; rs11306155; rs11292631; rs10635278; rs36130333; rs5786275; rs34170073; rs34925924; rs34972346; rs11599006; rs11002140; rs34464622; rs11819263; rs11002150; rs36024854; rs12266438; rs35650107; rs35113470; rs11591346; rs12146319; rs7476721; rs36127832; rs12252301; rs35232081; rs11002213; rs7087813; rs11002225; rs11595789; rs35650392; rs5786293; rs5786269; rs36034012; rs994074; rs4261229; rs34736679; rs17502433; rs35281727; rs34323979; rs35397755; rs36100746; rs1897587; rs35490368; rs34366427; rs12772853; rs7910415; rs4414159; rs11001995; rs34524709; rs35368463; rs5786273; rs2925799; rs2574814; rs12240748; rs35706946; rs1824207; rs12413744; rs9415153; rs35086371; rs34567556; rs12263556; rs11334660; rs1247753; rs35974389; rs35661463; rs12246819; rs34195608; rs7476129; rs11001939; rs34722999; rs34496101; rs34348979; rs7913117; rs35782147; rs4980114; rs35394873; rs34510105; rs7903851; rs35864746; rs12416293; rs12256620; rs34282184; rs10535903; rs4344435; rs28384354; rs12414699; rs182297; rs35433532; rs34009957; rs35449198; rs12049738; rs35058760; rs35955488; rs658906; rs1926704; rs35905149; rs28676468; rs34060353; rs877211; rs1515418; rs5786247; rs11002106; rs12240290; rs11388686; rs35527205; rs34265995; rs7084266; rs34495556; rs11002040; rs182324; rs1993854; rs35876623; rs2670162; rs12260510; rs11002093; rs12782391; rs287183; rs11002218; rs28439872; rs3781146; rs35099453; rs34035122; rs2580805; rs35324170; rs36071133; rs34345244; rs3851036; rs10670040; rs1371460; rs12777278; rs9416114; rs35338863; rs12255161; rs35222524; rs287200; rs865996; rs34394335; rs11297506; rs35701403; rs11002076; rs35189565; rs4471363; rs11002146; rs1659786; rs11405950; rs5786290; rs11001925; rs4980129; rs11325401; rs7087625; rs12770207; rs5786298; rs12783605; rs11379938; rs34189993; rs7077738; rs28562702; rs730330; rs35646612; rs34646112; rs4486567; rs34440077; rs35820939; rs11447627; rs35091810; rs34876953; rs12763065; rs10602891; rs11351133; rs36047967; rs41274572; rs5786252; rs34108487; rs2395481; rs12764364; rs10672811; rs11002025; rs1866592; rs287191; rs12765673; rs1898968; rs41274574; rs34187534; rs28368316; rs35288680; rs41421544; rs11002003; rs34797913; rs12414369; rs34228557; rs12415950; rs34655850; rs11598246; rs12355446; rs11002100; rs10666173; rs35442566; rs34888174; rs11001930; rs12265133; rs190379; rs11298052; rs12775194; rs10716625; rs11356947; rs11001977; rs289277; rs3998088; rs34906872; rs34175824; rs11436499; rs12262464; rs12250501; rs35511246; rs7908407; rs11001964; rs4979896; rs34209871; rs35217097; rs12765292; rs35981703; rs4979895; rs35025464; rs11001928; rs36047389; rs4641400; rs34161066; rs34243146; rs10699200; rs34513571; rs12764157; rs35244797; rs4979879; rs9416113; rs34172446; rs12358717; rs7903709; rs12256292; rs11813298; rs3068682; rs4979891; rs34184702; rs35370106; rs7071666; rs12762724; rs35951686; rs12766879; rs1371461; rs12259719; rs12781197; rs12778339; rs12783438; rs34084815; rs35930793; rs5786257; rs12413882; rs35365842; rs7073168; rs11002214; rs11001949; rs34238032; rs35536891; rs12769692; rs35375473; rs4384338; rs4979783; rs938518; rs36143700; rs10684248; rs34016608; rs35398166; rs28441546; rs35366821; rs12570321; rs12411327; rs7906437; rs35143501; rs34384634; rs11002141; rs1865024; rs6143994; rs36125057; rs35797893; rs11001921; rs11435423; rs36087456; rs12357749; rs34550967; rs10529840; rs12240536; rs34848390; rs35693128; rs36201547; rs12413426; rs4979900; rs34470453; rs34127380; rs166108; rs12240978; rs11002202; rs34130212; rs7083346; rs35145229; rs9943320; rs12765652; rs10673009; rs34104993; rs34902037; rs5786294; rs11001945; rs34094946; rs12263654; rs1079035; rs5786300; rs35933377; rs2719994; rs11363467; rs12761957; rs12764579; rs35031198; rs12264494; rs507278; rs5786276; rs35360076; rs35851885; rs7903711; rs1907739; rs34394378; rs35587291; rs3068597; rs35867052; rs11594230; rs34962545; rs10551406; rs10638309; rs2574801; rs11002080; rs35119991; rs4344436; rs4295988; rs35198770; rs3068573; rs11378891; rs11002012; rs7068024; rs1907736; rs2894355; rs35233838; rs2395478; rs34509332; rs34592624; rs12764752; rs727002; rs35187195; rs34349026; rs2720006; rs35682176; rs3067639; rs2619637; rs106242; rs1072397; rs10740459; rs10762731; rs10824458; rs11001911; rs11594258; rs12248045; rs12262892; rs1247760; rs1439786; rs1531224; rs1531225; rs1531226; rs166991; rs16933964; rs16934811; rs183280; rs1897595; rs193376; rs2077236; rs2244688; rs2619636; rs2812414; rs2812415; rs2812418; rs34297220; rs34612033; rs4620665; rs4980108; rs4980109; rs4980111; rs4980112; rs604677; rs650019; rs667497; rs697171; rs697172; rs703261; rs703262; rs7071206; rs7079589; rs938221

# Macromolecular_Interacting_Partner_4_General_References:
7877450; 7573516; 7993625; 7987297; 8821792; 9391153; 8962157; 10097176; 10692449

# Macromolecular_Interacting_Partner_4_References:
Not Available

# Macromolecular_Interacting_Partner_5_ID:
7088

# Macromolecular_Interacting_Partner_5_Name:
Epsilon-sarcoglycan precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
Epsilon-SG

# Macromolecular_Interacting_Partner_5_Gene_Name:
SGCE

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Epsilonsarcoglycan precursor
MSPATTGTFLLTVYSIFSKVHSDRNVYPSAGVLFVHVLEREYFKGEFPPYPKPGEISNDP
ITFNTNLMGYPDRPGWLRYIQRTPYSDGVLYGSPTAENVGKPTIIEITAYNRRTFETARH
NLIINIMSAEDFPLPYQAEFFIKNMNVEEMLASEVLGDFLGAVKNVWQPERLNAINITSA
LDRGGRVPLPINDLKEGVYVMVGADVPFSSCLREVENPQNQLRCSQEMEPVITCDKKFRT
QFYIDWCKISLVDKTKQVSTYQEVIRGEGILPDGGEYKPPSDSLKSRDYYTDFLITLAVP
SAVALVLFLILAYIMCCRREGVEKRNMQTPDIQLVHHSAIQKSTKELRDMSKNREIAWPL
STLPVFHPVTGEIIPPLHTDNYDSTNMPLMQTQQWSFAPVAQAGVQWRDLGSLQPPPPRN
LPHQTQIPQQQTTGKWYP

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
438

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
49754

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.32

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  protein binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  cellular process
Process:  cell adhesion
Process:  cell-cell adhesion
Process:  homophilic cell adhesion
 ||
>>>
Component:  protein complex
Component:  sarcoglycan complex
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF05510:Sarcoglycan_2

# Macromolecular_Interacting_Partner_5_Signals:
1-22

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
294-314

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
2852695

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
SGCE_HUMAN (O43556)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
SGCE

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
SGCE

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:10808

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Cell membrane; sarcolemma; single-pass type I membrane protein (Potential)

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>438 bp
GGGATTTTACCTGATGGTGGAGAATACAAACCCCCTTCTGATTCTTTGAAAAGCAGAGAC
TATTACACGGATTTCCTAATTACACTGGCTGTGCCCTCGGCAGTGGCACTGGTCCTTTTT
CTAATACTTGCTTATATCATGTGCTGCCGACGGGAAGGCGTGGAAAAGAGAAACATGCAA
ACACCAGACATCCAACTGGTCCATCACAGTGCTATTCAGAAATCTACCAAGGAGCTTCGA
GACATGTCCAAGAATAGAGAGATAGCATGGCCCCTGTCAACGCTTCCTGTGTTCCACCCT
GTGACTGGGGAAATCATACCTCCTTTACACACAGACAACTATGATAGCACAAACATGCCA
TTGATGCAAACGCAGCAGAACTTGCCACATCAGACTCAGATTCCCCAACAGCAGACTACA
GGTAAATGGTATCCCTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AF031920

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_5_Locus:
7q21-q22

# Macromolecular_Interacting_Partner_5_SNPs:
rs13225971; rs2037496; rs1357318; rs10232398; rs1878588; rs1568214; rs1879854; rs7783198; rs4330611; rs885573; rs7778237; rs10499905; rs17166393; rs12704731; rs10231656; rs13245233; rs1915989; rs10235385; rs10241344; rs10953114; rs13307062; rs12704730; rs10272757; rs17400776; rs10260642; rs17166404; rs10247562; rs13241095; rs883176; rs17166402; rs7778029; rs6943782; rs17166410; rs17166406; rs1851422; rs7809129; rs1357316; rs17166394; rs12113805; rs11980118; rs13226201; rs10225862; rs10274271; rs883174; rs17166376; rs10267027; rs17479086; rs17166382; rs12234469; rs17166409; rs12704733; rs12670168; rs11972527; rs17166375; rs6980229; rs17166384; rs12704732; rs9656022; rs1915988; rs13235539; rs6465421; rs12704728; rs13241489; rs1000714; rs2272091; rs6979891; rs17166371; rs10247056; rs11548284; rs11548286; rs11548285; rs17851923; rs9641141; rs3922687; rs35122653; rs34162841; rs28498968; rs13245774; rs4407799; rs34173737; rs33909846; rs11770181; rs28507629; rs34140372; rs12533301; rs5885873; rs883175; rs3045714; rs13245017; rs12704727; rs3045711; rs10226206; rs13242321; rs34805207; rs34752695; rs35710037; rs13245793; rs13245775; rs10225333; rs34646287; rs35686665; rs1533833; rs34944430; rs28380230; rs41278803; rs13226892; rs34592076; rs28614163; rs34458970; rs11422778; rs34807369; rs34660181; rs35069255; rs35492090; rs35980816; rs10256885; rs11381327; rs10224050; rs34311900; rs13226896; rs5885874; rs6962866; rs34753451; rs35787172; rs1053647; rs13238830; rs11770122; rs34890547; rs36037021; rs35169617; rs34719881; rs34747123; rs13307770; rs1522546; rs34507732; rs35000110; rs34569386; rs2177178; rs35825030; rs35639288; rs34731098; rs35016618; rs5885871; rs35481362; rs11389101; rs1522543; rs28439281; rs4729141; rs6971583; rs10233613; rs28543048; rs35723940; rs34703841; rs13227202; rs12704729; rs28684666; rs11973272; rs5885872; rs34657572; rs13245864; rs28727478; rs7459123; rs34988075; rs11770125; rs34542079; rs35685364; rs11331999; rs13222972; rs36031593; rs11984148; rs34577258; rs10239643; rs10263559; rs11976522; rs11980206; rs11983951; rs12534176; rs13232545; rs1607257; rs1609528; rs17166413; rs17400379; rs2621206; rs2687062; rs2687063; rs3209061; rs35039803; rs35237090; rs3750105; rs3814104; rs4530967; rs4729140; rs9692104

# Macromolecular_Interacting_Partner_5_General_References:
9475163; 9405466

# Macromolecular_Interacting_Partner_5_References:
Not Available

# Macromolecular_Interacting_Partner_6_ID:
7197

# Macromolecular_Interacting_Partner_6_Name:
Corticotropin-lipotropin precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
Pro-opiomelanocortin; POMC[Contains: NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin]

# Macromolecular_Interacting_Partner_6_Gene_Name:
POMC

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Corticotropinlipotropin precursor
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
267

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
29424

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Beta-endorphin and Met-enkephalin are endogenous opiates

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00976:ACTH_domain;
PF08384:NPP;
PF08035:Op_neuropeptide

# Macromolecular_Interacting_Partner_6_Signals:
1-26

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
190188

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
COLI_HUMAN (P01189)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
POMC

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
POMC

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:9201

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>789 bp
TGCAGCCGCTCGGGGGCCCTGTTGCTGGCCTTGCTGCTTCAGGCCTCCATGGAAGTGCGT
GGCTGGTGCCTGGAGAGCAGCCAGTGTCAGGACCTCACCACGGAAAGCAACCTGCTGGAG
TGCATCCGGGCCTGCAAGCCCGACCTCTCGGCCGAGACTCCCATGTTCCCGGGAAATGGC
GACGAGCAGCCTCTGACCGAGAACCCCCGGAAGTACGTCATGGGCCACTTCCGCTGGGAC
CGATTCGGCCGCCGCAACAGCAGCAGCAGCGGCAGCAGCGGCGCAGGGCAGAAGCGCGAG
GACGTCTCAGCGGGCGAAGACTGCGGCCCGCTGCCTGAGGGCGGCCCCGAGCCCCGCAGC
GATGGTGCCAAGCCGGGCCCGCGCGAGGGCAAGCGCTCCTACTCCATGGAGCACTTCCGC
TGGGGCAAGCCGGTGGGCAAGAAGCGGCGCCCAGTGAAGGTGTACCCTAACGGCGCCGAG
GACGAGTCGGCCGAGGCCTTCCCCCTGGAGTTCAAGAGGGAGCTGACTGGCCAGCGACTC
CGGGAGGGAGATGGCCCCGACGGCCCTGCCGATGACGGCGCAGGGGCCCAGGCCGACCTG
GAGCACAGCCTGCTGGTGGCGGCCGAGAAGAAGGACGAGGGCCCCTACAGGATGGAGCAC
TTCCGCTGGGGCAGCCCGCCCAAGGACAAGCGCTACGGCGGTTTCATGACCTCCGAGAAG
AGCCAGACGCCCCTGGTGACGCTGTTCAAAAACGCCATCATCAAGAACGCCTACAAGAAG
GGCGAGTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
M38297

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_6_Locus:
2p23.3

# Macromolecular_Interacting_Partner_6_SNPs:
rs28932472; rs8192606; rs28932471; rs35254395; rs8192605; rs28930368; rs2071345; rs34650613; rs1042571; rs11679531; rs6713532; rs7565877; rs6713396; rs12473543; rs6756695; rs6545975; rs6756566; rs28932474; rs28932476; rs28932475; rs28932473; rs10654394; rs28932470; rs3039380; rs35411223; rs35023083; rs33950052; rs7591899; rs15461; rs2071344; rs13388660; rs9973478; rs11353932; rs13404336; rs7565427; rs34619618; rs8192607; rs35639116; rs34526166; rs10188864; rs10195561; rs11892647; rs12472851; rs13418937; rs17046887; rs17046891; rs1866146; rs2071343; rs2118404; rs2164808; rs3769671; rs3795955; rs3820935; rs6545976; rs6719226; rs6734859; rs7589318; rs7605927; rs934778

# Macromolecular_Interacting_Partner_6_General_References:
6274691; 6299668; 6314261; 3606677; 6254047; 6945581; 6267033; 6272808; 4352834; 4334191; 4338630; 4347148; 1264228; 195688; 2424570; 2839146; 7828531; 9768693; 10193875; 11244459

# Macromolecular_Interacting_Partner_6_References:
17010143; 17067358

# Macromolecular_Interacting_Partner_7_ID:
7549

# Macromolecular_Interacting_Partner_7_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_7_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Name:
INS

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_7_Signals:
1-24

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
INS

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_7_Locus:
11p15.5

# Macromolecular_Interacting_Partner_7_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_7_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_7_References:
17020909; 17024851; 17065813

# Macromolecular_Interacting_Partner_8_ID:
6559

# Macromolecular_Interacting_Partner_8_Name:
Mitogen-activated protein kinase 3

# Macromolecular_Interacting_Partner_8_Synonyms:
Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAPK 1; p44-ERK1; ERT2; p44-MAPK; Microtubule- associated protein 2 kinase

# Macromolecular_Interacting_Partner_8_Gene_Name:
MAPK3

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Mitogenactivated protein kinase 3
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
379

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
43136

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
6.74

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00069:Pkinase

# Macromolecular_Interacting_Partner_8_Signals:
None

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
EC 2.7.11.24

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
31221

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
MK03_HUMAN (P27361)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
MAPK3

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
MAPK3

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:6877

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1140 bp
ATGGCGGCGGCGGCGGCTCAGGGGGGCGGGGGCGGGGAGCCCCGTAGAACCGAGGGGGTC
GGCCCGGGGGTCCCGGGGGAGGTGGAGATGGTGAAGGGGCAGCCGTTCGACGTGGGCCCG
CGCTACACGCAGTTGCAGTACATCGGCGAGGGCGCGTACGGCATGGTCAGCTCGGCCTAT
GACCACGTGCGCAAGACTCGCGTGGCCATCAAGAAGATCAGCCCCTTCGAACATCAGACC
TACTGCCAGCGCACGCTCCGGGAGATCCAGATCCTGCTGCGCTTCCGCCATGAGAATGTC
ATCGGCATCCGAGACATTCTGCGGGCGTCCACCCTGGAAGCCATGAGAGATGTCTACATT
GTGCAGGACCTGATGGAGACTGACCTGTACAAGTTGCTGAAAAGCCAGCAGCTGAGCAAT
GACCATATCTGCTACTTCCTCTACCAGATCCTGCGGGGCCTCAAGTACATCCACTCCGCC
AACGTGCTCCACCGAGATCTAAAGCCCTCCAACCTGCTCAGCAACACCACCTGCGACCTT
AAGATTTGTGATTTCGGCCTGGCCCGGATTGCCGATCCTGAGCATGACCACACCGGCTTC
CTGACGGAGTATGTGGCTACGCGCTGGTACCGGGCCCCAGAGATCATGCTGAACTCCAAG
GGCTATACCAAGTCCATCGACATCTGGTCTGTGGGCTGCATTCTGGCTGAGATGCTCTCT
AACCGGCCCATCTTCCCTGGCAAGCACTACCTGGATCAGCTCAACCACATTCTGGGCATC
CTGGGCTCCCCATCCCAGGAGGACCTGAATTGTATCATCAACATGAAGGCCCGAAACTAC
CTACAGTCTCTGCCCTCCAAGACCAAGGTGGCTTGGGCCAAGCTTTTCCCCAAGTCAGAC
TCCAAAGCCCTTGACCTGCTGGACCGGATGTTAACCTTTAACCCCAATAAACGGATCACA
GTGGAGGAAGCGCTGGCTCACCCCTACCTGGAGCAGTACTATGACCCGACGGATGAGCCA
GTGGCCGAGGAGCCCTTCACCTTCGCCATGGAGCTGGATGACCTACCTAAGGAGCGGCTG
AAGGAGCTCATCTTCCAGGAGACAGCACGCTTCCAGCCCGGAGTGCTGGAGGCCCCCTAG


# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
X60188

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_8_Locus:
16p11.2

# Macromolecular_Interacting_Partner_8_SNPs:
rs1143695; rs11865086; rs11864737; rs9921806; rs12922100; rs11863765; rs9930013; rs11546680; rs41292376; rs41291696; rs41280862; rs35691465; rs41280866; rs41280860; rs41280864; rs35666305; rs11644927; rs7199920; rs12918285; rs36084237; rs34799400; rs34564246; rs9940575; rs9940581; rs28529403; rs1042404; rs1062543; rs12924137; rs12930241; rs13569; rs1561414; rs2005219; rs3751867; rs7542; rs7698; rs8061772

# Macromolecular_Interacting_Partner_8_General_References:
7687743; 1540184; 1319925; 8794306

# Macromolecular_Interacting_Partner_8_References:
17107949

# Macromolecular_Interacting_Partner_9_ID:
7717

# Macromolecular_Interacting_Partner_9_Name:
Transient receptor potential cation channel subfamily M member 8

# Macromolecular_Interacting_Partner_9_Synonyms:
Transient receptor potential-p8; Trp-p8; Long transient receptor potential channel 6; LTrpC6

# Macromolecular_Interacting_Partner_9_Gene_Name:
TRPM8

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Transient receptor potential cation channel subfamily M member 8
MSFRAARLSMRNRRNDTLDSTRTLYSSASRSTDLSYSESDLVNFIQANFKKRECVFFTKD
SKATENVCKCGYAQSQHMEGTQINQSEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYIRL
SCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQY
LMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIP
IVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEVEDALTSSAVKEKLVR
FLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSE
QDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN
GLNLRKFLTHDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR
NGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKT
LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA
VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPVDKH
KKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFC
DEVRQWYVNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFT
LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIF
RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV
CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAY
FYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH
RFRQLDTKLNDLKGLLKEIANKIK

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
1104

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
127686

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
7.25

# Macromolecular_Interacting_Partner_9_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Signals:
None

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
692-712
735-755
760-780
795-815
830-850
959-979

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
20147036

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
TRPM8_HUMAN (Q7Z2W7)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
TRPM8

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
TRPM8

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:17961

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Membrane; multi-pass membrane protein (Probable)

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>3315 bp
ATGTCCTTTCGGGCAGCCAGGCTCAGCATGAGGAACAGAAGGAATGACACTCTGGACAGC
ACCCGGACCCTGTACTCCAGCGCGTCTCGGAGCACAGACTTGTCTTACAGTGAAAGCGAC
TTGGTGAATTTTATTCAAGCAAATTTTAAGAAACGAGAATGTGTCTTCTTTATCAAAGAT
TCCAAGGCCACGGAGAATGTGTGCAAGTGTGGCTATGCCCAGAGCCAGCACATGGAAGGC
ACCCAGATCAACCAAAGTGAGAAATGGAACTACAAGAAACACACCAAGGAATTTCCTACC
GACGCCTTTGGGGATATTCAGTTTGAGACACTGGGGAAGAAAGGGAAGTATATACGTCTG
TCCTGCGACACGGACGCGGAAATCCTTTACGAGCTGCTGACCCAGCACTGGCACCTGAAA
ACACCCAACCTGGTCATTTCTGTGACCGGGGGCGCCAAGAACTTCGCCCTGAAGCCGCGC
ATGCGCAAGATCTTCAGCCGGCTCATCTACATCGCGCAGTCCAAAGGTGCTTGGATTCTC
ACGGGAGGCACCCATTATGGCCTGATGAAGTACATCGGGGAGGTGGTGAGAGATAACACC
ATCAGCAGGAGTTCAGAGGAGAATATTGTGGCCATTGGCATAGCAGCTTGGGGCATGGTC
TCCAACCGGGACACCCTCATCAGGAATTGCGATGCTGAGGGCTATTTTTTAGCCCAGTAC
CTTATGGATGACTTCACAAGAGATCCACTGTATATCCTGGACAACAACCACACACATTTG
CTGCTCGTGGACAATGGCTGTCATGGACATCCCACTGTCGAAGCAAAGCTCCGGAATCAG
CTAGAGAAGTATATCTCTGAGCGCACTATTCAAGATTCCAACTATGGTGGCAAGATCCCC
ATTGTGTGTTTTGCCCAAGGAGGTGGAAAAGAGACTTTGAAAGCCATCAATACCTCCATC
AAAAATAAAATTCCTTGTGTGGTGGTGGAAGGCTCGGGCCAGATCGCTGATGTGATCGCT
AGCCTGGTGGAGGTGGAGGATGCCCTGACATCTTCTGCCGTCAAGGAGAAGCTGGTGCGC
TTTTTACCCCGCACGGTGTCCCGGCTGCCTGAGGAGGAGACTGAGAGTTGGATCAAATGG
CTCAAAGAAATTCTCGAATGTTCTCACCTATTAACAGTTATTAAAATGGAAGAAGCTGGG
GATGAAATTGTGAGCAATGCCATCTCCTACGCTCTATACAAAGCCTTCAGCACCAGTGAG
CAAGACAAGGATAACTGGAATGGGCAGCTGAAGCTTCTGCTGGAGTGGAACCAGCTGGAC
TTAGCCAATGATGAGATTTTCACCAATGACCGCCGATGGGAGTCTGCTGACCTTCAAGAA
GTCATGTTTACGGCTCTCATAAAGGACAGACCCAAGTTTGTCCGCCTCTTTCTGGAGAAT
GGCTTGAACCTACGGAAGTTTCTCACCCATGATGTCCTCACTGAACTCTTCTCCAACCAC
TTCAGCACGCTTGTGTACCGGAATCTGCAGATCGCCAAGAATTCCTATAATGATGCCCTC
CTCACGTTTGTCTGGAAACTGGTTGCGAACTTCCGAAGAGGCTTCCGGAAGGAAGACAGA
AATGGCCGGGACGAGATGGACATAGAACTCCACGACGTGTCTCCTATTACTCGGCACCCC
CTGCAAGCTCTCTTCATCTGGGCCATTCTTCAGAATAAGAAGGAACTCTCCAAAGTCATT
TGGGAGCAGACCAGGGGCTGCACTCTGGCAGCCCTGGGAGCCAGCAAGCTTCTGAAGACT
CTGGCCAAAGTGAAGAACGACATCAATGCTGCTGGGGAGTCCGAGGAGCTGGCTAATGAG
TACGAGACCCGGGCTGTTGAGCTGTTCACTGAGTGTTACAGCAGCGATGAAGACTTGGCA
GAACAGCTGCTGGTCTATTCCTGTGAAGCTTGGGGTGGAAGCAACTGTCTGGAGCTGGCG
GTGGAGGCCACAGACCAGCATTTCATCGCCCAGCCTGGGGTCCAGAATTTTCTTTCTAAG
CAATGGTATGGAGAGATTTCCCGAGACACCAAGAACTGGAAGATTATCCTGTGTCTGTTT
ATTATACCCTTGGTGGGCTGTGGCTTTGTATCATTTAGGAAGAAACCTGTCGACAAGCAC
AAGAAGCTGCTTTGGTACTATGTGGCGTTCTTCACCTCCCCCTTCGTGGTCTTCTCCTGG
AATGTGGTCTTCTACATCGCCTTCCTCCTGCTGTTTGCCTACGTGCTGCTCATGGATTTC
CATTCGGTGCCACACCCCCCCGAGCTGGTCCTGTACTCGCTGGTCTTTGTCCTCTTCTGT
GATGAAGTGAGACAGTGGTACGTAAATGGGGTGAATTATTTTACTGACCTGTGGAATGTG
ATGGACACGCTGGGGCTTTTTTACTTCATAGCAGGAATTGTATTTCGGCTCCACTCTTCT
AATAAAAGCTCTTTGTATTCTGGACGAGTCATTTTCTGTCTGGACTACATTATTTTCACT
CTAAGATTGATCCACATTTTTACTGTAAGCAGAAACTTAGGACCCAAGATTATAATGCTG
CAGAGGATGCTGATCGATGTGTTCTTCTTCCTGTTCCTCTTTGCGGTGTGGATGGTGGCC
TTTGGCGTGGCCAGGCAAGGGATCCTTAGGCAGAATGAGCAGCGCTGGAGGTGGATATTC
CGTTCGGTCATCTACGAGCCCTACCTGGCCATGTTCGGCCAGGTGCCCAGTGACGTGGAT
GGTACCACGTATGACTTTGCCCACTGCACCTTCACTGGGAATGAGTCCAAGCCACTGTGT
GTGGAGCTGGATGAGCACAACCTGCCCCGGTTCCCCGAGTGGATCACCATCCCCCTGGTG
TGCATCTACATGTTATCCACCAACATCCTGCTGGTCAACCTGCTGGTCGCCATGTTTGGC
TACACGGTGGGCACCGTCCAGGAGAACAATGACCAGGTCTGGAAGTTCCAGAGGTACTTC
CTGGTGCAGGAGTACTGCAGCCGCCTCAATATCCCCTTCCCCTTCATCGTCTTCGCTTAC
TTCTACATGGTGGTGAAGAAGTGCTTCAAGTGTTGCTGCAAGGAGAAAAACATGGAGTCT
TCTGTCTGCTGTTTCAAAAATGAAGACAATGAGACTCTGGCATGGGAGGGTGTCATGAAG
GAAAACTACCTTGTCAAGATCAACACAAAAGCCAACGACACCTCAGAGGAAATGAGGCAT
CGATTTAGACAACTGGATACAAAGCTTAATGATCTCAAGGGTCTTCTGAAAGAGATTGCT
AATAAAATCAAATAA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
AY090109

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_9_Locus:
2q37.1

# Macromolecular_Interacting_Partner_9_SNPs:
rs7593557; rs17868387; rs13004520; rs17862932; rs11562975; rs11563071; rs11563208; rs11563130; rs737636; rs6709005; rs2190951; rs10803665; rs7604471; rs4497869; rs10803664; rs737635; rs6431648; rs10170399; rs7602303; rs4664001; rs4663986; rs11563199; rs4233636; rs2362291; rs11563221; rs7597116; rs17862921; rs1003757; rs1003756; rs6741751; rs11562973; rs763380; rs2017655; rs11563201; rs4663984; rs17862920; rs11563054; rs3732213; rs11562977; rs11563220; rs9646718; rs11563200; rs763379; rs17869077; rs11901004; rs11563254; rs4663985; rs12988953; rs2052029; rs10172388; rs11563062; rs12105689; rs2052030; rs17866591; rs11901051; rs10172275; rs17865681; rs2362295; rs1024607; rs735551; rs1024608; rs758276; rs2215173; rs2362294; rs10490014; rs2302153; rs10929319; rs2108809; rs7595960; rs11563216; rs6711120; rs4663998; rs10803666; rs12473889; rs6431651; rs4233637; rs11695247; rs4663994; rs10929321; rs6431649; rs6717651; rs7601861; rs4663341; rs10171428; rs6750653; rs7560562; rs6712540; rs6708995; rs13418652; rs12619960; rs4663999; rs6736916; rs10189040; rs6723922; rs4233638; rs4663996; rs728671; rs7562971; rs11563060; rs735552; rs7569987; rs4663995; rs7562952; rs6431652; rs10490016; rs11689034; rs12476852; rs7577157; rs10929329; rs4663991; rs4663345; rs13401339; rs6758653; rs10929324; rs10166496; rs740550; rs9646720; rs4663343; rs758275; rs4664000; rs10803667; rs10169266; rs10490010; rs7605850; rs6734618; rs10170647; rs6721761; rs917435; rs4663344; rs12470426; rs10490018; rs10490019; rs17863841; rs4663342; rs6712893; rs11563056; rs11892658; rs6740118; rs11563212; rs17865676; rs11563059; rs17864757; rs6751169; rs11563217; rs7564831; rs3732214; rs12472151; rs12468783; rs10929327; rs7576321; rs6723443; rs6714489; rs6721957; rs11563202; rs6756537; rs17869070; rs11563058; rs6709823; rs13414162; rs6714644; rs887065; rs11562993; rs11563128; rs11563210; rs11886103; rs11563127; rs6431650; rs11563219; rs6749421; rs13028228; rs11902618; rs6719854; rs10490013; rs10432393; rs7562378; rs10490017; rs12692252; rs728672; rs7606865; rs11563055; rs11563061; rs6712962; rs758277; rs17863842; rs12185625; rs2108810; rs11563215; rs11562976; rs4663989; rs13421820; rs6752001; rs11563209; rs7569211; rs887064; rs6706861; rs6738375; rs11563206; rs11563124; rs13411202; rs11562992; rs9646719; rs11563031; rs10490012; rs11562948; rs4663988; rs7558436; rs17863840; rs12995775; rs17862928; rs11562994; rs2362292; rs17869068; rs12478399; rs11562954; rs10929320; rs4663992; rs11563125; rs2362293; rs12999395; rs17863848; rs12620352; rs7607001; rs10188366; rs12617866; rs10519360; rs13024825; rs11563204; rs11563029; rs11563214; rs17865679; rs11563253; rs7420034; rs4663987; rs10210459; rs6746331; rs12466401; rs10180847; rs10207672; rs7592709; rs11682848; rs11563126; rs1548690; rs17864753; rs10490011; rs2190952; rs11563207; rs11563218; rs10490015; rs6745987; rs13034437; rs11562942; rs12465950; rs4663993; rs11563009; rs7597012; rs17868396; rs12692251; rs6710801; rs6718140; rs12995095; rs11562974; rs11685673; rs1008355; rs11563057; rs17864768; rs11563203; rs6727222; rs1016062; rs10182895; rs13024921; rs11898669; rs17864764; rs17868394; rs17864779; rs17869074; rs13421753; rs10211203; rs12476648; rs17864746; rs11563211; rs17869073; rs10196968; rs7564119; rs6758678; rs17865677; rs17863853; rs2885478; rs12621049; rs12623777; rs12992084; rs17868384; rs4663990; rs17862943; rs17866588; rs2005791; rs10197047; rs6719311; rs6713715; rs6749354; rs17864758; rs17874955; rs7607540; rs17864777; rs11679873; rs6705259; rs17864770; rs17865678; rs7605226; rs11679197; rs41328844; rs11686469; rs17865674; rs17864759; rs11684966; rs1860162; rs6706623; rs17869069; rs17868397; rs17862942; rs740549; rs7422827; rs7421125; rs17869072; rs17868389; rs11682757; rs17864755; rs11691335; rs17874956; rs13020968; rs11563030; rs28514310; rs4663997; rs7421127; rs17864761; rs6760498; rs10929328; rs7558883; rs1019103; rs17863851; rs17862931; rs12620418; rs17868402; rs17868400; rs17864744; rs41128; rs17863844; rs1003540; rs10929331; rs1004478; rs10203291; rs1965629; rs10166942; rs9789366; rs17865682; rs17865683; rs10929318; rs17865684; rs9789398; rs1985366; rs1118259; rs9789675; rs2362290; rs41371544; rs11690675; rs1987842; rs34709945; rs28902201; rs35124867; rs11368966; rs28902173; rs28901637; rs28901630; rs34316917; rs28901601; rs35163686; rs28902474; rs34090396; rs11562963; rs28901603; rs17864780; rs28946906; rs13023831; rs28948677; rs35409049; rs28901602; rs28901607; rs34459106; rs13032378; rs11318897; rs34523697; rs34492021; rs28901604; rs34774481; rs34426413; rs28902475; rs10685994; rs28901608; rs10675460; rs28901605; rs36087103; rs11373529; rs34877212; rs12990134; rs28902238; rs35157671; rs28901600; rs35884761; rs28901606; rs34109711; rs13023823; rs11422376; rs28902237; rs28901651; rs28902182; rs28902205; rs28902194; rs35415321; rs28901638; rs35695658; rs28902230; rs28902171; rs35630487; rs28948676; rs34052025; rs11563129; rs5839499; rs11433963; rs17862926; rs28901618; rs34515959; rs34796091; rs11563132; rs28902187; rs34996735; rs28901627; rs28901624; rs11312917; rs34052230; rs17874952; rs28948671; rs35021268; rs35173283; rs28901869; rs35662363; rs28902223; rs28901656; rs13035502; rs13034919; rs28901879; rs28902225; rs28902218; rs28901644; rs35238710; rs17864745; rs35982332; rs28902220; rs28901628; rs28902234; rs28953470; rs3952145; rs28902231; rs28902200; rs28902229; rs17868390; rs28901885; rs34301170; rs34095183; rs28902477; rs35745753; rs10535391; rs34118000; rs28901632; rs13029075; rs17868403; rs28946912; rs28901874; rs28901611; rs34301158; rs28902176; rs11325904; rs34817253; rs41127; rs11563205; rs28902209; rs28953468; rs17864742; rs28901645; rs28901888; rs28901619; rs10700294; rs28902228; rs28901654; rs28902222; rs28946913; rs35091332; rs28902191; rs41557919; rs28902213; rs28902212; rs17868393; rs28901641; rs34770229; rs5839500; rs35228816; rs28902183; rs34225370; rs35495354; rs28901873; rs2108808; rs17874951; rs33924049; rs17864771; rs28902206; rs28901868; rs35644215; rs28901881; rs17864774; rs28901622; rs28901649; rs28901640; rs28902768; rs28902199; rs28902233; rs28902202; rs34601211; rs28901878; rs28901650; rs28902172; rs28902217; rs28902216; rs28902195; rs28902190; rs28901623; rs17864766; rs17864773; rs28901631; rs11563032; rs28902178; rs28901612; rs12185590; rs3078202; rs28948673; rs28902177; rs28901655; rs28901884; rs11563131; rs10659716; rs17863849; rs17864763; rs28902188; rs34464856; rs10572559; rs10432392; rs17864762; rs11450151; rs17874950; rs28901883; rs28901626; rs28902211; rs35123718; rs28948668; rs35379195; rs28902174; rs34032602; rs35873472; rs28901872; rs28901621; rs35282569; rs28946910; rs28901647; rs28902207; rs28902184; rs28902236; rs34723843; rs17863847; rs11562970; rs28901636; rs28902196; rs28901646; rs36115024; rs35062089; rs36019228; rs28901616; rs17864749; rs28901871; rs28948674; rs6755982; rs35022769; rs17862939; rs17864748; rs35021904; rs28901634; rs28901615; rs28902189; rs17865680; rs28902168; rs28901639; rs28901613; rs28902179; rs28946909; rs17868401; rs28948672; rs34984521; rs28902227; rs17862925; rs28901877; rs28902221; rs28901653; rs28902215; rs28901609; rs35875128; rs17864772; rs13019120; rs28902180; rs17863843; rs11375668; rs28901887; rs35171208; rs28901625; rs28901635; rs28902175; rs13035474; rs28902208; rs28901620; rs13032519; rs35182913; rs28902235; rs28902203; rs35702211; rs28902476; rs28901648; rs28902198; rs28901882; rs28901870; rs35533329; rs28901610; rs28948675; rs28901617; rs28902224; rs34450729; rs28902185; rs13034132; rs17868395; rs28901643; rs28902193; rs10432391; rs28946911; rs34853446; rs28948669; rs28902219; rs28901652; rs28902210; rs17862929; rs28901614; rs35177121; rs28948670; rs28901880; rs11305740; rs28901633; rs28902186; rs28902169; rs17874953; rs13019115; rs11563213; rs28953469; rs28902232; rs28902170; rs28901642; rs17869071; rs5839498; rs28902181; rs35282814; rs28902197; rs28902204; rs28946908; rs28901886; rs28645349; rs28946907; rs28901876; rs28902226; rs28902214; rs28901629; rs28901875; rs28902192; rs17868391; rs35060197; rs35588579; rs28902239; rs28901598; rs28901599; rs36206145; rs34870473; rs35144672; rs35201441; rs35039547; rs10084247; rs1024688; rs10519356; rs10929332; rs11562955; rs11562957; rs11563063; rs11563198; rs11677046; rs11679031; rs11681894; rs11682121; rs11683566; rs11684714; rs11892538; rs12473717; rs12474996; rs12477019; rs1395837; rs1395840; rs17863838; rs17864741; rs17864782; rs17864783; rs17864784; rs17864785; rs17864789; rs17864791; rs17865685; rs17865686; rs17865687; rs17865692; rs17866592; rs17866593; rs17866594; rs17866595; rs17866602; rs17866604; rs17869079; rs17869080; rs17869085; rs17869087; rs2108806; rs2108807; rs28948678; rs35481104; rs4233635; rs4663347; rs4663349; rs591103; rs599294; rs601129; rs601885; rs602312; rs602371; rs603217; rs604082; rs663924; rs664373; rs668355; rs6707645; rs6724624; rs6738979; rs676546; rs676959; rs679207; rs683719; rs7577262; rs7582832; rs9287650

# Macromolecular_Interacting_Partner_9_General_References:
11325849

# Macromolecular_Interacting_Partner_9_References:
17074062

# Macromolecular_Interacting_Partner_10_ID:
8008

# Macromolecular_Interacting_Partner_10_Name:
Adiponectin precursor

# Macromolecular_Interacting_Partner_10_Synonyms:
Adipocyte, C1q and collagen domain-containing protein; 30 kDa adipocyte complement-related protein; Adipocyte complement-related 30 kDa protein; ACRP30; Adipose most abundant gene transcript 1; apM-1; Gelatin-binding protein

# Macromolecular_Interacting_Partner_10_Gene_Name:
ADIPOQ

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Adiponectin precursor
MLLLGAVLLLLALPGHDQETTTQGPGVLLPLPKGACTGWMAGIPGHPGHNGAPGRDGRDG
TPGEKGEKGDPGLIGPKGDIGETGVPGAEGPRGFPGIQGRKGEPGEGAYVYRSAFSVGLE
TYVTIPNMPIRFTKIFYNQQNHYDGSTGKFHCNIPGLYYFAYHITVYMKDVKVSLFKKDK
AMLFTYDQYQENNVDQASGSVLLHLEVGDQVWLQVYGEGERNGLYADNDNDSTFTGFLLY
HDTN

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
244

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
26414

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
5.53

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00386:C1q;
PF01391:Collagen

# Macromolecular_Interacting_Partner_10_Signals:
1-18

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
871887

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
ADIPO_HUMAN (Q15848)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
ADIPOQ

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
ADIPOQ

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:13633

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>735 bp
ATGCTGTTGCTGGGAGCTGTTCTACTGCTATTAGCTCTGCCCGGGCATGACCAGGAAACC
ACGACTCAAGGGCCCGGAGTCCTGCTTCCCCTGCCCAAGGGGGCCTGCACAGGTTGGATG
GCGGGCATCCCAGGGCATCCGGGCCATAATGGGGCCCCAGGCCGTGATGGCAGAGATGGC
ACCCCTGGTGAGAAGGGTGAGAAAGGAGATCCAGGTCTTATTGGTCCTAAGGGAGACATC
GGTGAAACCGGAGTACCCGGGGCTGAAGGTCCCCGAGGCTTTCCGGGAATCCAAGGCAGG
AAAGGAGAACCTGGAGAAGGTGCCTATGTATACCGCTCAGCATTCAGTGTGGGATTGGAG
ACTTACGTTACTATCCCCAACATGCCCATTCGCTTTACCAAGATCTTCTACAATCAGCAA
AACCACTATGATGGCTCCACTGGTAAATTCCACTGCAACATTCCTGGGCTGTACTACTTT
GCCTACCACATCACAGTCTATATGAAGGATGTGAAGGTCAGCCTCTTCAAGAAGGACAAG
GCTATGCTCTTCACCTATGATCAGTACCAGGAAAATAATGTGGACCAGGCCTCCGGCTCT
GTGCTCCTGCATCTGGAGGTGGGCGACCAAGTCTGGCTCCAGGTGTATGGGGAAGGAGAG
CGTAATGGACTCTATGCTGATAATGACAATGACTCCACCTTCACAGGCTTTCTTCTCTAC
CATGACACCAACTGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
D45371

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_10_Locus:
3q27

# Macromolecular_Interacting_Partner_10_SNPs:
rs17366743; rs2241766; rs2082940; rs1063537; rs1063539; rs822394; rs7649121; rs1063538; rs182052; rs9877202; rs7627128; rs822395; rs12495941; rs6773957; rs6444174; rs4686804; rs17366568; rs6414520; rs9882205; rs822396; rs4686803; rs822388; rs16861205; rs822389; rs16861209; rs11711059; rs6444172; rs822393; rs9842733; rs1501298; rs16861210; rs2036373; rs17366653; rs4068; rs12635510; rs17846866; rs822391; rs9882097; rs3774262; rs2241767; rs3821799; rs3774261; rs1501299; rs266729; rs17300539; rs1403697; rs16861194; rs12492612; rs13061862; rs12639220; rs10575960; rs35469083; rs710445; rs34046054; rs35759948; rs12494576; rs17846865; rs34534547; rs34422369; rs16861222; rs34463314; rs36219755; rs1501297; rs11451767; rs11434648; rs36219760; rs11412081; rs17366499; rs34225626; rs13066093; rs35993781; rs11429836; rs35378606; rs16861220; rs17846872; rs36219758; rs35615373; rs822392; rs35310830; rs10662925; rs10662615; rs10545762; rs36219762; rs34265972; rs33955672; rs35595243; rs6789230; rs7649044; rs6796106; rs11377702; rs12495855; rs34513325; rs4686440; rs34568537; rs34156726; rs35088921; rs34814577; rs266730; rs11711353; rs12629945; rs1403695; rs1403696; rs1648707; rs17373414; rs1827311; rs1865762; rs34187390; rs4607097; rs4632532; rs6444175; rs6808791; rs7628649; rs7641507; rs7653711; rs864265

# Macromolecular_Interacting_Partner_10_General_References:
8619847; 10095105; 10403784; 10961870; 10982546; 11479627; 10918532; 11812766

# Macromolecular_Interacting_Partner_10_References:
17047161

# Macromolecular_Interacting_Partner_11_ID:
8781

# Macromolecular_Interacting_Partner_11_Name:
Zinc-binding alcohol dehydrogenase domain-containing protein 2

# Macromolecular_Interacting_Partner_11_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_11_Gene_Name:
ZADH2

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Zincbinding alcohol dehydrogenase domaincontaining protein 2
MLRLVPTGARAIVDMSYARHFLDFQGSAIPQAMQKLVVTRLSPNFREAVTLSRDCPVPLP
GDGDLLVRNRFVGVNASDINYSAGRYDPSVKPPFDIGFEGIGEVVALGLSASARYTVGQA
VAYMAPGSFAEYTVVPASIATPVPSVKPEYLTLLVSGTTAYISLKELGGLSEGKKVLVTA
AAGGTGQFAMQLSKKAKCHVIGTCSSDEKSAFLKSLGCDRPINYKTEPVGTVLKQEYPEG
VDVVYESVGGAMFDLAVDALATKGRLIVIGFISGYQTPTGLSPVKAGTLPAKLLKKSASV
QGFFLNHYLSKYQAAMSHLLEMCVSGDLVCEVDLGDLSPEGRFTGLESIFRAVNYMYMGK
NTGKIVVELPHSVNSKL

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
377

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
40141

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
8.32

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
 Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_11_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_11_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF08240:ADH_N
PF00107:ADH_zinc_N

# Macromolecular_Interacting_Partner_11_Signals:
Not Available

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
21707266

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
ZADH2_HUMAN (Q8N4Q0)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
ZADH2

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
ZADH2

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:28697

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>1134 bp
ATGCTGCGGCTGGTGCCCACCGGGGCCCGGGCCATCGTGGACATGTCGTACGCCCGCCAC
TTCCTGGACTTCCAGGGCTCCGCCATTCCCCAAGCCATGCAGAAGCTGGTGGTGACCCGG
CTGAGCCCCAACTTCCGCGAGGCCGTCACCCTGAGCCGGGACTGCCCGGTGCCGCTCCCC
GGGGACGGAGACCTCCTCGTCCGGAACCGATTTGTTGGTGTTAACGCATCTGACATCAAC
TATTCAGCAGGCCGCTATGACCCCTCAGTTAAGCCTCCCTTTGACATAGGTTTCGAAGGC
ATTGGGGAGGTGGTGGCCCTAGGCCTCTCTGCTAGTGCCAGATACACAGTTGGCCAAGCT
GTGGCTTACATGGCACCTGGTTCTTTTGCTGAGTACACAGTTGTGCCTGCCAGCATTGCA
ACTCCAGTGCCCTCAGTGAAACCCGAGTATCTTACCCTGCTGGTAAGTGGCACCACCGCA
TACATCAGCCTGAAAGAGCTCGGAGGACTGTCGGAAGGGAAAAAAGTTTTGGTGACAGCA
GCAGCTGGGGGAACGGGCCAGTTTGCCATGCAGCTTTCAAAGAAGGCAAAGTGCCATGTA
ATTGGAACCTGCTCTTCTGATGAAAAGTCTGCTTTTCTGAAATCTCTTGGCTGTGATCGT
CCTATCAACTATAAAACTGAACCCGTAGGTACCGTCCTTAAGCAGGAGTACCCTGAAGGT
GTCGATGTGGTCTATGAATCTGTTGGGGGAGCCATGTTTGACTTGGCTGTAGACGCCCTG
GCTACGAAAGGGCGCTTGATAGTAATAGGGTTTATCTCTGGCTACCAAACTCCTACTGGC
CTTTCGCCTGTGAAAGCAGGAACATTGCCAGCCAAACTGCTCAAGAAATCTGCCAGCGTA
CAGGGCTTCTTCCTGAACCATTACCTTTCTAAGTATCAAGCAGCCATGAGCCACTTGCTC
GAGATGTGTGTGAGCGGAGACCTGGTTTGTGAGGTGGACCTTGGAGATCTGTCTCCAGAG
GGCAGGTTTACTGGCCTGGAGTCCATATTCCGTGCTGTCAATTATATGTACATGGGAAAA
AACACTGGAAAAATTGTAGTTGAATTACCTCACTCTGTCAACAGTAAGCTGTAA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
BC033780

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:18

# Macromolecular_Interacting_Partner_11_Locus:
18q22.3

# Macromolecular_Interacting_Partner_11_SNPs:
rs17056661; rs7230037; rs632157; rs9240; rs2292233; rs17056651; rs17181586; rs1132845; rs17056648; rs1866730; rs1972887; rs2581648; rs2639963; rs2639989; rs7237736; rs1047521; rs615360; rs658974; rs1047526; rs2289438; rs34616479; rs35407927; rs2581647; rs1660084; rs17056649; rs17056670; rs2639962; rs35601535; rs1866728; rs34385379; rs1866729; rs12969004; rs7242350; rs11307633; rs2639990; rs35583435; rs12458587; rs35976070; rs1047524; rs1129562; rs1129563; rs1047528; rs10626255; rs10163911; rs35832670; rs10163698; rs1039743; rs10460107; rs11660312; rs12326420; rs12605885; rs12970215; rs1440298; rs1702832; rs17056615; rs1866731; rs2439254; rs2439255; rs2581650; rs2581651; rs2581652; rs2581653; rs2581654; rs2639974; rs2639993; rs4891050; rs4891240; rs4891241; rs4891244; rs4891246; rs590483; rs607917; rs623223; rs629081; rs629126; rs634687; rs635553; rs637318; rs640261; rs643767; rs643811; rs733070; rs906508; rs906509; rs931920; rs931921; rs9962947

# Macromolecular_Interacting_Partner_11_General_References:
Not Available

# Macromolecular_Interacting_Partner_11_References:
Not Available

End of HMDB00108

Beginning of HMDB00112
# Accession_No:
HMDB00112

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-02 15:30:28

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
gamma-Aminobutyric acid

# Description:
Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter found in the nervous systems of widely divergent species. It is the chief inhibitory neurotransmitter in the vertebrate central nervous system. In vertebrates, GABA acts at inhibitory synapses in the brain. GABA acts by binding to specific transmembrane receptors in the plasma membrane of both pre- and postsynaptic neurons. This binding causes the opening of ion channels to allow either the flow of negatively-charged chloride ions into the cell or positively-charged potassium ions out of the cell. This will typically result in a negative change in the transmembrane potential, usually causing hyperpolarization. Three general classes of GABA receptor are known. These include GABAA and GABAC ionotropic receptors, which are ion channels themselves, and GABAB metabotropic receptors, which are G protein-coupled receptors that open ion channels via intermediaries (G proteins). Neurons that produce GABA as their output are called GABAergic neurons, and have chiefly inhibitory action at receptors in the vertebrate. Medium Spiny Cells are a typical example of inhibitory CNS GABAergic cells. GABA exhibits excitatory actions in insects, mediating muscle activation at synapses between nerves and muscle cells and also the stimulation of certain glands. GABA has also been shown to have excitatory roles in the vertebrate, most notably in the developing cortex. Organisms synthesize GABA from glutamate using the enzyme L-glutamic acid decarboxylase and pyridoxal phosphate as a cofactor. It is worth noting that this involves converting the principal excitatory neurotransmitter (glutamate) into the principal inhibitory one (GABA). Drugs that act as agonists of GABA receptors (known as GABA analogues or GABAergic drugs) or increase the available amount of GABA typically have relaxing, anti-anxiety and anti-convulsive effects. (http://en.wikipedia.org/wiki/GABA)  Doses of GABA 1 to 3 g orally also have been used effectively to raise the IQ of mentally retarded persons. GABA is found to be deficient in cerebrospinal fluid and brain in many studies of experimental and human epilepsy. Benzodiazepines (such as Valium) are useful in status epilepticus because they act on GABA receptors. GABA increases in the brain after administration of many seizure medications. Hence, GABA is clearly an antiepileptic nutrient. Inhibitors of GAM metabolism can also produce convulsions. Spasticity and involuntary movement syndromes, e.g., Parkinson's, Friedreich's ataxia, tardive dyskinesia, and Huntington's chorea are all marked by low GABA when amino acid levels are studied. Trials of 2 to 3 g of GABA given orally have been effective in various epilepsy and spasticity syndromes. Agents that elevate GABA also are useful in lowering hypertension. Three grams orally have been effective in control of blood pressure. GABA is decreased in various encephalopathies. GABA can reduce appetite and is decreased in hypoglycemics. GABA reduces blood sugar in diabetics. Chronic brain syndromes can also be marked by deficiency of GABA; GABA has many promising uses in therapy.  Cerebrospinal fluid levels of GABA may be useful in diagnosing very serious diseases. Vitamin B6, manganese, taurine and lysine can increase both GABA synthesis and effects, while aspartic acid and Glutamic acid probably inhibit GABA effects. (http://www.dcnutrition.com/AminoAcids/Detail.CFM)The brain's principal inhibitory neurotransmitter, GABA, along with serotonin and norepinephrine, is one of several neurotransmitters that appear to be involved in the pathogenesis of anxiety and mood disorders. There are two principal subtypes of postsynaptic GABA receptor complexes, the GABA-A and GABA-B receptor complexes. Activation of the GABA-B receptor by GABA causes neuronal membrane hyperpolarization and a resultant inhibition of neurotransmitter release. In addition to binding sites for GABA, the GABA-A receptor has binding sites for benzodiazepines, barbiturates, and neurosteroids. GABA-A receptors are coupled to chloride ion channels; activation of the receptor induces increased inward chloride ion flux, resulting in membrane hyperpolarization and neuronal inhibition. After release into the synapse, free GABA that does not bind to either the GABA-A or GABA-B receptor complexes can be taken up by neurons and glial cells. Four different membrane transporter proteins, known as GAT-1, GAT-2, GAT-3, and BGT-1, which differ in their distribution in the CNS, are believed to mediate the uptake of synaptic GABA into neurons and glial cells. The GABA-A receptor subtype regulates neuronal excitability and rapid changes in fear arousal, such as anxiety, panic, and the acute stress response. Drugs that stimulate GABA-A receptors, such as the benzodiazepines and barbiturates, have anxiolytic and anti-seizure effects via GABA-A-mediated reduction of neuronal excitability, which effectively raises the seizure threshold. In support of the anticonvulsant and anxiolytic effects of the GABA-A receptor are findings that GABA-A antagonists produce convulsions in animals and the demonstration that there is decreased GABA-A receptor binding in a positron emission tomography (PET) study of patients with panic disorder. Low plasma GABA has been reported in some depressed patients and, in fact, may be a useful trait marker for mood disorders. (The Role Of GABA In The Pathogenesis And Treatment Of Anxiety And Other Neuropsychiatric Disorders: http://www.vcu-cme.org/gaba/overview.html)

# Synonyms:
3-Carboxypropylamine; 4-Aminobutanoate; 4-Aminobutanoic acid; 4-Aminobutyrate; 4-Aminobutyric acid; Aminalon; GABA; Gaballon; Gamarex; Gamma aminobutyrate; Gamma aminobutyric acid; Gamma-aminobutyrate; Gamma-aminobutyric acid; Gammalon; Gammalone; Gammar; Gammasol; Mielogen; Mielomade; Piperidate; Piperidic acid; Piperidinate; Piperidinic acid; w-Aminobutyrate; w-Aminobutyric acid; omega-Aminobutyrate; omega-Aminobutyric acid

# Chemical_IUPAC_Name:
4-amino-Butanoic acid

# Chemical_Formula:
C4H9NO2

# Chemical_Structure:
tbl_chemical:::HMDB00112_ZOOM.png:::119283193043970968

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00112_THUMB.png:::119283192885369228

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids; Nitrogenous Compounds

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid

# Taxonomy_Biofunction:
Component of Alanine and aspartate metabolism; Component of beta-Alanine metabolism; Component of Butanoate metabolism; Component of Glutamate metabolism; Component of Taurine and hypotaurine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
103.06333

# Molecular_Weight_Avg:
103.11977

# Smiles_String_isomeric:
NCCCC(O)=O

# Smiles_String_canonical:
NCCCC(O)=O

# KEGG_Compound_ID:
C00334

# BioCyc_ID:
4-AMINO-BUTYRATE

# PubChem_CID:
119

# PubChem_SID:
11335791; 10323897; 8145275; 8139983; 8138144; 11376129; 3131894; 8138279; 148764; 11491200; 3628; 11367967; 11484732; 10527343; 7885654; 8149630; 8150467; 7847126; 11462002; 11374436; 841798; 2023; 8138105; 710516; 11493863; 11489024; 11361030; 7979337; 5006226; 7989498; 11113457; 11110722; 11365405; 11372289; 90737; 99151; 588080; 11362843; 8138251; 87901; 11492624; 102735

# OMIM_ID:
137150

# Metagene_ID:
Not Available

# BiGG_ID:
34652

# Wikipedia_ID:
GABA

# METLIN_ID:
Not Available

# Ref_ID:
12097436; 16037152; 15956168; 16043137; 12445190; 16527506; 16032672; 14726441; 8432013; 15538143; 6198481; 10534261; 1485027; 11121859; 7473299

# ChEBI_ID:
16865

# CAS_Registry_Number:
56-12-2

# InChI:
InChI=1/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

# Synthesis_Reference:
ynthesis of 4-aminobutyric acid and 2,4-diaminobutyric acid from butyrolactone.     Talbot, Guy; Gaudry, Roger; Berlinguet, Louis.    Laval Univ.,  QC,    Canadian Journal of Chemistry  (1958),  36  593-6.

# Melting_Point:
203 oC

# Melting_Point_predicted:
26.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1300.0 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
365.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-3.17 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-2.98 [Predicted by ALOGPS]; -0.7 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::g-Aminobutyric acid.pdf:::1132562201030831071

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::gamma-Aminobutyric_acid.mol:::1132723807828258901

# SDF_File_[Text]:
tbl_chemical:::HMDB00112.sdf:::119283192584145154

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00112.pdb:::119283192748674699

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041026_P00_01_HW_1DP_presat.zip:::114866422206789200

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041026_P00_01_HW_1DP_presat.png:::114866422224638211

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041026_P00_01_HW_1DP_Assigned.png:::115644655610686483

# C_NMR_Spectra:
tbl_cnmr:::041026_P00_01_HW_1DC_1.jpg:::114168459753426892

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041026_P00_01_HW_1DC_1.zip:::114168459750641883

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041026_P00_01_HW_1DC_1_Assigned.jpg:::114322930435453624

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041026_P00_01_HW_2DHSQC_494.jpg:::114781200024581688

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041026_P00_01_HW_2DHSQC_494.zip:::114781200027195936

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041026_P00_01_HW_2DHSQC_494_Assigned.jpg:::114781200040842780

# Predicted_H_NMR_Spectrum:
tbl_chemical:::gamma-Aminobutyric acid.gif:::1132732109562388498

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00112_peaks.txt:::1156309550315878294

# Predicted_C_NMR_Spectrum:
tbl_chemical:::gamma-Aminobutyric acid_C.gif:::1132737686439503906

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00112_peaks.txt:::1156310740512581671

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00112L.png:::117555261960978428; Medium Energy:tbl_ms:::HMDB00112M.png:::117555267075764671; High Energy:tbl_ms:::HMDB00112H.png:::117555270942165093

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP); Extracellular; lysosome; mitochondria

# Tissue_Location:
Adrenal Cortex; Brain; Epidermis; Fibroblasts; Hippocampus; Kidney; Muscle; Nerve Cells; Neuron; Neurons; Spleen; Testis

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Urine	<0.461	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Urine	0.17 +/- 0.025	umol/mmol_creatinine	Adult:>18_yrs_old	Female	Normal	11121859
Blood	0.110 +/- 0.23	uM	Adult:>18_yrs_old	Both	Normal	1485027
Cerebrospinal_Fluid(CSF)	0.32 (0.2 -0.45)	uM	Adult:>18_yrs_old	Both	Normal	7473299
Cerebrospinal_Fluid(CSF)	0.23 +/- 0.075	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	0.093 (0.083-0.10)	umol/L	Adult:>18_yrs_old	Both	Normal	8432013
Saliva	>10	umol/L	Adult:>18_yrs_old	Both	Normal	12097436


# Concentration_[Abnormal]:
Cerebrospinal_Fluid(CSF)	1.5 +/- 1.1 	umol/L	Adult:>18_yrs_old	N/A	Epilepsy 	10534261
Cerebrospinal_Fluid(CSF)	0.1 (0.063 - 0.179)	uM	Children:1-13_yrs_old	N/A	Children with febrile convulsions	6198481
Cerebrospinal_Fluid(CSF)	0.52 - 0.57	uM	Children:1-13_yrs_old	N/A	Epileptic children on valproate treatment	6198481
Cerebrospinal_Fluid(CSF)	0.11 (0.067 - 0.176)	uM	Children:1-13_yrs_old	N/A	Untreated epileptic children	6198481
Cerebrospinal_Fluid(CSF)	0.1 (0.061 - 0.171)	N/A	Children:1-13_yrs_old	Both	Children with acute meningitis	6198481
Cerebrospinal_Fluid(CSF)	4.0 +/- 4.2 	uM	Adult:>18_yrs_old	Both	Epilepsy treated with Vigabatrin	10534261
Cerebrospinal_Fluid(CSF)	0.0002 +/- 0.000013	uM	Adult:>18_yrs_old	Both	Tuberculous meningitis	9542731
Cerebrospinal_Fluid(CSF)	0.00013 +/- 0.00002	uM	Adult:>18_yrs_old	Both	Aseptic meningitis	9542731


# Associated_Disorders:
Aseptic meningitis; Children with acute meningitis; Children with febrile convulsions; Epilepsy; Epilepsy treated with Vigabatrin; Epileptic children on valproate treatment; Ischemic Stroke; Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency; Tuberculous meningitis; Untreated epileptic children

# Pathway_Names:
Pyruvate metabolism;Glycolysis;Fatty acid metabolism;Bile acid biosynthesis;Glycerolipid metabolism

# Pathway_Images:
;Glycolysis.jpg;;;

# KEGG_Images:
map00620;map00010;map00071;map00120;map00561

# Pathway_Graphs:
;Glycolysis_Graph.jpg;;;

# Pathway_SBMLs:
;Glycolysis.xml;;;

# Metabolic_Enzyme_1_ID:
6060

# Metabolic_Enzyme_1_Name:
Alcohol dehydrogenase class 3

# Metabolic_Enzyme_1_Synonyms:
Alcohol dehydrogenase class III; Alcohol dehydrogenase class chi chain; S-; hydroxymethylglutathione dehydrogenase; Glutathione- dependent formaldehyde dehydrogenase; FDH

# Metabolic_Enzyme_1_Gene_Name:
ADH5

# Metabolic_Enzyme_1_Protein_Sequence:
>Alcohol dehydrogenase class 3
MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGC
FPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGK
GLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGY
GAAVNTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATEC
INPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEE
IATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFE
LMHSGKSIRTVVKI

# Metabolic_Enzyme_1_Number_of_Residues:
374

# Metabolic_Enzyme_1_Molecular_Weight:
39725

# Metabolic_Enzyme_1_Theoretical_pI:
7.54

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione

# Metabolic_Enzyme_1_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_1_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.1.1.1;EC 1.1.1.284

# Metabolic_Enzyme_1_GenBank_ID_Protein:
178134

# Metabolic_Enzyme_1_SwissProt_ID:
ADHX_HUMAN (P11766)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ADH5

# Metabolic_Enzyme_1_Geneatlas_id:
ADH5

# Metabolic_Enzyme_1_hgnc_id:
HGNC:253

# Metabolic_Enzyme_1_PDB_ID:
1MC5

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1125 bp
ATGGCGAACGAGGTTATCAAGTGCAAGGCTGCAGTTGCTTGGGAGGCTGGAAAGCCTCTC
TCCATAGAGGAGATAGAGGTGGCACCCCCAAAGGCTCATGAAGTTCGAATCAAGATCATT
GCCACTGCGGTTTGCCACACCGATGCCTATACCCTGAGTGGAGCTGATCCTGAGGGTTGT
TTTCCAGTGATCTTGGGACATGAAGGTGCTGGAATTGTGGAAAGTGTTGGTGAGGGAGTT
ACTAAGCTGAAGGCGGGTGACACTGTCATCCCACTTTACATCCCACAGTGTGGAGAATGC
AAATTTTGTCTAAATCCTAAAACTAACCTTTGCCAGAAGATAAGAGTCACTCAAGGGAAA
GGATTAATGCCAGATGGTACCAGCAGATTTACTTGCAAAGGAAAGACAATTTTGCATTAC
ATGGGAACCAGCACATTTTCTGAATACACAGTTGTGGCTGATATCTCTGTTGCTAAAATA
GATCCTTTAGCACCTTTGGATAAAGTCTGCCTTCTAGGTTGTGGCATTTCAACCGGTTAT
GGTGCTGCTGTGAACACTGCCAAGTTGGAGCCTGGCTCTGTTTGTGCCGTCTTTGGTCTG
GGAGGAGTCGGATTGGCAGTTATCATGGGCTGTAAAGTGGCTGGTGCTTCCCGGATCATT
GGTGTGGACATCAATAAAGATAAATTTGCAAGGGCCAAAGAGTTTGGAGCCACTGAATGT
ATTAACCCTCAGGATTTTAGTAAACCCATCCAGGAAGTGCTCATTGAGATGACCGATGGA
GGAGTGGACTATTCCTTTGAATGTATTGGTAATGTGAAGGTCATGAGAGCAGCACTTGAG
GCATGTCACAAGGGCTGGGGCGTCAGCGTCGTGGTTGGAGTAGCTGCTTCAGGTGAAGAA
ATTGCCACTCGTCCATTCCAGCTGGTAACAGGTCGCACATGGAAAGGCACTGCCTTTGGA
GGATGGAAGAGTGTAGAAAGTGTCCCAAAGTTGGTGTCTGAATATATGTCCAAAAAGATA
AAAGTTGATGAATTTGTGACTCACAATCTGTCTTTTGATGAAATCAACAAAGCCTTTGAA
CTGATGCATTCTGGAAAGAGCATTCGAACTGTTGTAAAGATTTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M30471

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_1_Locus:
4q21-q25

# Metabolic_Enzyme_1_SNPs:
rs16996593; rs28730623; rs28730643; rs7669660; rs1803037; rs13832; rs11568816; rs6827292; rs12106; rs11547772; rs28730650; rs1061187; rs28730645; rs28730646; rs17028487; rs12697; rs28730649; rs1154410; rs7683802; rs896992; rs1154411; rs1154405; rs6846829; rs7683704; rs1154401; rs1154414; rs17028505; rs17028500; rs7658279; rs4699701; rs4699700; rs7688859; rs6852848; rs7658127; rs7658118; rs7666867; rs3018048; rs7688835; rs7688531; rs13109048; rs7688686; rs4699699; rs1154412; rs17595424; rs28730592; rs28730605; rs28894371; rs1154415; rs28730639; rs13145727; rs28985868; rs28730576; rs28730607; rs28730581; rs28730569; rs28730624; rs1154404; rs28730641; rs28730597; rs28730601; rs28730578; rs28730590; rs28730575; rs1154409; rs1154402; rs13118409; rs28730612; rs29001350; rs28730632; rs28730571; rs29001346; rs28730603; rs28730594; rs29001583; rs28730596; rs29001348; rs28730582; rs28730620; rs28730619; rs28730637; rs13127586; rs28730608; rs28730568; rs28730640; rs28894370; rs28730600; rs28730630; rs13146416; rs28730644; rs28730625; rs28730617; rs1154416; rs29001345; rs28730610; rs28730584; rs28730602; rs9799556; rs13125919; rs28730636; rs28730587; rs28730621; rs29001347; rs28730573; rs28730611; rs28730593; rs28730595; rs28730627; rs29001351; rs35123946; rs2866033; rs28730613; rs28730629; rs1154403; rs13119035; rs28730589; rs11934304; rs29001349; rs28730631; rs28730591; rs29001631; rs28730604; rs28730570; rs7684735; rs7679102; rs1154400; rs7684986; rs17216887; rs7662987; rs7667261; rs2602899; rs29001338; rs29001341; rs28730655; rs29001336; rs1230158; rs13132688; rs29001339; rs17028482; rs2851301; rs28987121; rs29001340; rs1050636; rs1050637; rs28730628; rs28730652; rs28730653; rs28730648; rs29001343; rs1803038; rs28730647; rs28730651; rs28730583; rs28730599; rs33990814; rs34370152; rs1154406; rs34443372; rs28730606; rs28730616; rs28730586; rs34609488; rs34912906; rs11317364; rs28730585; rs35796474; rs28730618; rs28730634; rs28730626; rs28730572; rs28894372; rs1154413; rs5860558; rs34470866; rs28730622; rs28730635; rs29001344; rs28730598; rs35169500; rs28894368; rs6148593; rs34594585; rs29001542; rs28730588; rs28730609; rs28730577; rs28730633; rs28730615; rs28730580; rs29001570; rs3805321; rs33981706; rs1154407; rs1235433; rs28730574; rs34763643; rs36160699; rs34146172; rs3792680; rs10618658; rs28730638; rs35904284; rs13133011; rs34452464; rs1154408; rs33972516; rs28730656; rs1048578; rs29001342; rs10582873; rs3974877; rs28730657; rs36093781; rs1048577; rs5860559; rs10560641; rs11455235; rs10616090; rs35101663; rs35815329; rs11553737; rs29001335; rs28730658; rs11292055; rs34834932; rs2187482; rs10587720; rs34985976; rs1130076; rs34439422; rs28730654; rs29001337; rs10006953; rs1230154; rs1230155; rs1230157; rs1230164; rs1230165; rs1238741; rs1311615; rs1311616; rs1311617; rs1311621; rs13120000; rs1312200; rs1473371; rs15193; rs17028473; rs17595102; rs17595186; rs2602836; rs2851286; rs28730614; rs2924584; rs7664906; rs7667424; rs7681427; rs7687322

# Metabolic_Enzyme_1_General_References:
2818582; 2679557; 1446828; 3365377; 8494891; 8460164; 9018047

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6061

# Metabolic_Enzyme_2_Name:
3-mercaptopyruvate sulfurtransferase

# Metabolic_Enzyme_2_Synonyms:
MST

# Metabolic_Enzyme_2_Gene_Name:
MPST

# Metabolic_Enzyme_2_Protein_Sequence:
>3mercaptopyruvate sulfurtransferase
MASPQLCRALVSAQWVAEALRAPRAGQPLQLLDASWYLPKLGRDARREFEERHIPGAAFF
DIDQCSDRTSPYDHMLPGAEHFAEYAGRLGVGAATHVVIYDASDQGLYSAPRVWWMFRAF
GHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQLDPAFIKTYEDIKENLESRRFQV
VDSRATGRFRGTEPEPRDGIEPGHIPGTVNIPFTDFLSQEGLEKSPEEIRHLFQEKKVDL
SKPLVATCGSGVTACHVALGAYLCGKPDVPIYDGSWVEWYMRARPEDVISEGRGKTH

# Metabolic_Enzyme_2_Number_of_Residues:
297

# Metabolic_Enzyme_2_Molecular_Weight:
33179

# Metabolic_Enzyme_2_Theoretical_pI:
6.58

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfurtransferase activity
Function:  thiosulfate sulfurtransferase activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  sulfate transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. May have a role in cyanide degradation or in thiosulfate biosynthesis

# Metabolic_Enzyme_2_Pathway:
map00272  Cysteine metabolism

# Metabolic_Enzyme_2_Reaction:
3-mercaptopyruvate + cyanide = pyruvate + thiocyanate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00581:Rhodanese

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.8.1.2

# Metabolic_Enzyme_2_GenBank_ID_Protein:
432376

# Metabolic_Enzyme_2_SwissProt_ID:
THTM_HUMAN (P25325)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
MPST

# Metabolic_Enzyme_2_Geneatlas_id:
MPST

# Metabolic_Enzyme_2_hgnc_id:
HGNC:7223

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>891 bp
ATGGCTTCGCCGCAGCTCTGCCGCGCGCTGGTGTCGGCGCAATGGGTGGCGGAGGCGCTG
CGGGCCCCGCGCGCTGGGCAGCCTCTGCAGCTGCTGGACGCCTCCTGGTACCTGCCGAAG
CTGGGGCGCGACGCGACGCAGTTCGAGGAGCGCCACATCCCGGGCGCCGCTTTCTTCGAC
ATCGACCAGTGCAGCGACCGCACCTCGCCCTACGACCACATGCTGCCCGGGGCCGAGCAT
TTCGCGGAGTACGCAGGCCGCCTGGGCGTGGGCGCGGCCACCCACGTCGTGATCTACGAC
GCCAGCGACCAGGGCCTCTACTCCGCCCCGCGCGTCTGGTGGATGTTCCGCGCCTTCGGC
CACCACGCCGTGTCACTGCTTGATGGCGGCCTCCGCCACTGGCTGCGCCAGAACCTCCCG
CTCAGCTCCGGCAAGAGCCAACCTGCTCCCGCCGAGTTCCGCGCTCAGCTCGACCCCGCC
TTCATCAAGACCTACGAGGACATCAAGGAGAACCTGGAATCCCGGCGCTTCCAGGTGGTG
GACTCCCGAGCCACTGGCAGGTTCCGCGGCACCGAGCCCGAGCCCCGAGACGGCATTGAA
CCTGGCCACATCCCAGGTACCGTGAACATCCCCTTCACAGACTTCCTGAGCCAGGAGGGG
CTGGAGAAGAGCCCTGAGGAGATCCGCCATCTGTTCCAGGAGAAGAAAGTGGACCTGTCT
AAGCCACTGGTGGCCACGTGTGGCTCTGGCGTCACAGCCTGCCACGTGGCACTAGGGGCC
TACCTCTGCGGCAAGCCAGACGTGCCCATCTACGATGGCTCCTGGGTGGAGTGGTACATG
CGCGCCCGGCCCGAGGATGTCATCTCAGAGGGCCGGGGGAAGACCCACTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X59434

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_2_Locus:
22q13.1

# Metabolic_Enzyme_2_SNPs:
rs11704682; rs10427778; rs10427757; rs4821585; rs12158886; rs10427747; rs1049282; rs8141597; rs9607407; rs5756490; rs6000536; rs2187723; rs5756492; rs8136338; rs5750373; rs8136339; rs3753145; rs17850508; rs11547217; rs5750371; rs28626693; rs34526823; rs5756491; rs11403393; rs8138527; rs5995374; rs3753143; rs11376623; rs11403451; rs9610632; rs6000537; rs41280015; rs41280013; rs3753144; rs35546852; rs8135732; rs9622535; rs34362432; rs1049262; rs1049270; rs1049280; rs11912963; rs130598; rs130599; rs130607; rs130608; rs130617; rs135167; rs2157152; rs2187724; rs228129; rs228131; rs25095; rs34374682; rs34639542; rs35156365; rs35722346; rs470029; rs4764; rs4821582; rs4821583; rs4821584; rs5750366; rs5750370; rs5756476; rs5756477; rs5756479; rs5756482; rs5756489; rs6000533; rs6000534; rs6000539; rs715483; rs9610630; rs9622533

# Metabolic_Enzyme_2_General_References:
1953758; 10591208

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6062

# Metabolic_Enzyme_3_Name:
Alcohol dehydrogenase 1B

# Metabolic_Enzyme_3_Synonyms:
Alcohol dehydrogenase beta subunit

# Metabolic_Enzyme_3_Gene_Name:
ADH1B

# Metabolic_Enzyme_3_Protein_Sequence:
>Alcohol dehydrogenase 1B
MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVT
PLPVILGHEA
AGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGN
PRGTLQDGTRRFTCRGKPIHH
FLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFS
TGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVM
GCKAAGAARIIAVDINKDKFAKAKELG
ATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASL
LCCHEACGTSVIVGVP
PASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHV
LPFEK
INEGFDLLHSGKSIRTVLTF

# Metabolic_Enzyme_3_Number_of_Residues:
375

# Metabolic_Enzyme_3_Molecular_Weight:
39855

# Metabolic_Enzyme_3_Theoretical_pI:
8.38

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
An alcohol + NAD(+) = an aldehyde or ketone + NADH

# Metabolic_Enzyme_3_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_3_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_3_GenBank_ID_Protein:
178098

# Metabolic_Enzyme_3_SwissProt_ID:
ADH1B_HUMAN (P00325)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ADH1B

# Metabolic_Enzyme_3_Geneatlas_id:
ADH1B

# Metabolic_Enzyme_3_hgnc_id:
HGNC:250

# Metabolic_Enzyme_3_PDB_ID:
1HSZ

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>1128 bp

ATGAGCACAGCAGGAAAAGTAATCAAATGCAAAGCAGCTGTGCTATGGGAGGTAAAGAA
ACCCTTTTCCA
TTGAGGATGTGGAGGTTGCACCTCCTAAGGCTTATGAAGTTCGCATTA
AGATGGTGGCTGTAGGAATCTG
TCGCACAGATGACCACGTGGTTAGTGGCAACCTGGTG
ACCCCCCTTCCTGTGATTTTAGGCCATGAGGCA
GCCGGCATCGTGGAGAGTGTTGGAGA
AGGGGTGACTACAGTCAAACCAGGTGATAAAGTCATCCCGCTCT
TTACTCCTCAGTGTG
GAAAATGCAGAGTTTGTAAAAACCCGGAGAGCAACTACTGCTTGAAAAATGATCT
AGGC
AATCCTCGGGGGACCCTGCAGGATGGCACCAGGAGGTTCACCTGCAGGGGGAAGCCCATT
CACCAC
TTCCTTGGCACCAGCACCTTCTCCCAGTACACGGTGGTGGATGAGAATGCAGT
GGCCAAAATTGATGCAG
CCTCGCCCCTGGAGAAAGTCTGCCTCATTGGCTGTGGATTCT
CGACTGGTTATGGGTCTGCAGTTAACGT
TGCCAAGGTCACCCCAGGCTCTACCTGTGCT
GTGTTTGGCCTGGGAGGGGTCGGCCTATCTGCTGTTATG
GGCTGTAAAGCAGCTGGAGC
AGCCAGAATCATTGCGGTGGACATCAACAAGGACAAAAAAGCAAAGGCCA
AAGAGTTGG
GTGCCACTGAATGCATCAACCCTCAAGACTACAAGAAACCCATCCAGGAAGTGCTAAAGG
A
AATGACTGATGGAGGTGTGGATTTTTCGTTTGAAGTCATCGGTCGGCTTGACACCATG
ATGGCTTCCCTG
TTATGTTGTCATGAGGCATGTGGCACAAGCGTCATCGTAGGGGTACC
TCCTGCTTCCCAGAACCTCTCAA
TAAACCCTATGCTGCTACTGACTGGACGCACCTGGA
AGGGGGCTGTTTATGGTGGCTTTAAGAGTAAAGA
AGGTATCCCAAAACTTGTGGCTGAT
TTTATGGCTAAGAAGTTTTCACTGGATGCGTTAATAACCCATGTT
TTACCTTTTGAAAA
AATAAATGAAGGATTTGACCTGCTTCACTCTGGGAAAAGTATCCGTACCGTCCTGA
CGT
TTTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M24317

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_3_Locus:
4q21-q23

# Metabolic_Enzyme_3_SNPs:
rs6413413; rs2066702; rs1229984; rs1041969; rs28626993; rs1789882; rs2018417; rs1229983; rs1042026; rs17033; rs28914789; rs3840296; rs28914788; rs1353621; rs12498658; rs1693457; rs17028834; rs6850217; rs10005290; rs2066701; rs9282578; rs11730075; rs2075633; rs9282577; rs4147536; rs28913906; rs28914783; rs1235416; rs28914772; rs13133908; rs28914770; rs28914773; rs1229985; rs28914769; rs28913922; rs1789880; rs1229986; rs28913915; rs1789883; rs28914768; rs28914775; rs4147539; rs28914785; rs7673353; rs28914784; rs28913924; rs28913907; rs2018613; rs28913921; rs1159918; rs12507573; rs3811801; rs3811802; rs1229982; rs1693458; rs1229981; rs2070898; rs28913902; rs2070897; rs28914792; rs28913901; rs28914793; rs1789878; rs3133155; rs28914794; rs28913903; rs1126441; rs41275699; rs1126440; rs41275697; rs28914790; rs35274586; rs3211503; rs34503441; rs35273731; rs28913919; rs28914777; rs28913926; rs28914782; rs34044126; rs28913909; rs17028839; rs7441278; rs28913916; rs34689791; rs28913918; rs28914786; rs35046750; rs28914781; rs35105761; rs28914776; rs28913911; rs10711677; rs4147538; rs28914780; rs7435646; rs34702119; rs28913923; rs28914779; rs4147535; rs28913913; rs28913920; rs28913908; rs28913914; rs28913910; rs28913917; rs28913925; rs35822752; rs28914778; rs28913912; rs28914787; rs10033960; rs34198524; rs28914774; rs3840297; rs28914791; rs13114844; rs5860575; rs1789877; rs34004679; rs36208360; rs34739423; rs6839995; rs36038206; rs28913904; rs28913905; rs34644331; rs1789879; rs35468479; rs1229863; rs1229864; rs13103321; rs13117371; rs13145277; rs1693439; rs1789888; rs1789890; rs1789891; rs2213041; rs2866152; rs6810842; rs9307239

# Metabolic_Enzyme_3_General_References:
3000832; 2935533; 2935875; 2679216; 2547609; 6391920; 3397059; 6374651; 3619918; 1896463; 8201622; 8663387; 11274460; 10733556

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5754

# Metabolic_Enzyme_4_Name:
Alcohol dehydrogenase [NADP+]

# Metabolic_Enzyme_4_Synonyms:
Aldehyde reductase; Aldo- keto reductase family 1 member A1

# Metabolic_Enzyme_4_Gene_Name:
AKR1A1

# Metabolic_Enzyme_4_Protein_Sequence:
>Alcohol dehydrogenase NADP+
MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL
KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER
GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP
AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK
YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV
PMLTVDGKRVPRDAGHPLYPFNDPY

# Metabolic_Enzyme_4_Number_of_Residues:
325

# Metabolic_Enzyme_4_Molecular_Weight:
36573

# Metabolic_Enzyme_4_Theoretical_pI:
6.79

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes the NADPH-dependent reduction of a variety of aldehydes to their corresponding alcohols

# Metabolic_Enzyme_4_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00561  Glycerolipid metabolism;
 map00930  Caprolactam degradation

# Metabolic_Enzyme_4_Reaction:
an alcohol + NADP+ = an aldehyde + NADPH + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.1.1.2

# Metabolic_Enzyme_4_GenBank_ID_Protein:
178481

# Metabolic_Enzyme_4_SwissProt_ID:
AK1A1_HUMAN (P14550)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
AKR1A1

# Metabolic_Enzyme_4_Geneatlas_id:
AKR1A1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:380

# Metabolic_Enzyme_4_PDB_ID:
2ALR

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>978 bp
ATGGCGGCTTCCTGTGTTCTACTGCACACTGGGCAGAAGATGCCTCTGATTGGTCTGGGT
ACCTGGAAGAGTGAGCCTGGTCAGGTAAAAGCAGCTGTTAAGTATGCCCTTAGCGTAGGC
TACCGCCACATTGATTGTGCTGCTATCTACGGCAATGAGCCTGAGATTGGGGAGGCCCTG
AAGGAGGACGTGGGACCAGGCAAGGCGGTGCCTCGGGAGGAGCTGTTTGTGACATCCAAG
CTGTGGAACACCAAGCACCACCCCGAGGATGTGGAGCCTGCCCTCCGGAAGACTCTGGCT
GACCTCCAGCTGGAGTATCTGGACCTGTACCTGATGCACTGGCCTTATGCCTTTGAGCGG
GGAGACAACCCCTTCCCCAAGAATGCTGATGGGACTATATGCTACGACTCCACCCACTAC
AAGGAGACTTGGAAGGCTCTGGAGGCACTGGTGGCTAAGGGGCTGGTGCAGGCGCTGGGC
CTGTCCAACTTCAACAGTCGGCAGATTGATGACATACTCAGTGTGGCCTCCGTGCGTCCA
GCTGTCTTGCAGGTGGAATGCCACCCATACTTGGCTCAAAATGAGCTAATTGCCCACTGC
CAAGCACGTGGCTTGGAGGTAACTGCTTATAGCCCTTTGGGCTCCTCTGATCGTGCATGG
CGTGATCCTGATGAGCCTGTCCTGCTGGAGGAACCAGTAGTCCTGGCATTGGCTGAAAAG
TATGGCCGATCTCCAGCTCAGATCTTGCTCAGGTGGCAGGTCCAGCGGAAAGTGATCTGC
ATCCCCAAAAGTATCACTCCTTCTCGAATCCTTCAGAACATCAAGGTGTTTGACTTCACC
TTTAGCCCAGAAGAGATGAAGCAGCTAAATGCCCTGAACAAAAATTGGAGATATATTGTG
CCTATGCTTACGGTGGATGGGAAGAGAGTCCCAAGGGATGCAGGGCATCCTCTGTACCCC
TTTAATGACCCGTACTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
J04794

# Metabolic_Enzyme_4_Chromosome_Location:
Not Available

# Metabolic_Enzyme_4_Locus:
Not Available

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
2498333; 10486210; 3615425; 7669785

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
6063

# Metabolic_Enzyme_5_Name:
Alcohol dehydrogenase class 4 mu/sigma chain

# Metabolic_Enzyme_5_Synonyms:
Alcohol dehydrogenase class IV mu/sigma chain; Retinol dehydrogenase; Gastric alcohol dehydrogenase

# Metabolic_Enzyme_5_Gene_Name:
ADH7

# Metabolic_Enzyme_5_Protein_Sequence:
>Alcohol dehydrogenase class 4 mu/sigma chain
MGTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVS
KFPVIVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGR
GVLADGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGY
GAAVKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATEC
ISPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSAKM
LTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITHVLPFKKISEGFE
LLNSGQSIRTVLTF

# Metabolic_Enzyme_5_Number_of_Residues:
374

# Metabolic_Enzyme_5_Molecular_Weight:
40006

# Metabolic_Enzyme_5_Theoretical_pI:
8.08

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_5_Specific_Function:
Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism

# Metabolic_Enzyme_5_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_5_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_5_GenBank_ID_Protein:
516618

# Metabolic_Enzyme_5_SwissProt_ID:
ADH7_HUMAN (P40394)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ADH7

# Metabolic_Enzyme_5_Geneatlas_id:
ADH7

# Metabolic_Enzyme_5_hgnc_id:
HGNC:256

# Metabolic_Enzyme_5_PDB_ID:
1D1S

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1125 bp
ATGGGCACTGCTGGAAAAGTTATTAAGTGCAAAGCAGCTGTGCTTTGGGAGCAGAAGCAA
CCCTTCTCCATTGAGGAAATAGAAGTTGCCCCACCAAAGACTAAAGAAGTTCGCATTAAG
ATTTTGGCCACAGGAATCTGTCGCACAGATGACCATGTGATAAAAGGAACAATGGTGTCC
AAGTTTCCAGTGATTGTGGGACATGAGGCAACTGGGATTGTAGAGAGCATTGGAGAAGGA
GTGACTACAGTGAAACCAGGTGACAAAGTCATCCCTCTCTTTCTGCCACAATGTAGAGAA
TGCAATGCTTGTCGCAACCCAGATGGCAACCTTTGCATTAGGAGCGATATTACTGGTCGT
GGAGTACTGGCTGATGGCACCACCAGATTTACATGCAAGGGCAAACCAGTCCACCACTTC
ATGAACACCAGTACATTTACCGAGTACACAGTGGTGGATGAATCTTCTGTTGCTAAGATT
GATGATGCAGCTCCTCCTGAGAAAGTCTGTTTAATTGGCTGTGGGTTTTCCACTGGATAT
GGCGCTGCTGTTAAAACTGGCAAGGTCAAACCTGGTTCCACTTGCGTCGTCTTTGGCCTG
GGAGGAGTTGGCCTGTCAGTCATCATGGGCTGTAAGTCAGCTGGTGCATCTAGGATCATT
GGGATTGACCTCAACAAAGACAAATTTGAGAAGGCCATGGCTGTAGGTGCCACTGAGTGT
ATCAGTCCCAAGGACTCTACCAAACCCATCAGTGAGGTGCTGTCAGAAATGACAGGCAAC
AACGTGGGATACACCTTTGAAGTTATTGGGCATCTTGAAACCATGATTGATGCCCTGGCA
TCCTGCCACATGAACTATGGGACCAGCGTGGTTGTAGGAGTTCCTCCATCAGCCAAGATG
CTCACCTATGACCCGATGTTGCTCTTCACTGGACGCACATGGAAGGGATGTGTCTTTGGA
GGTTTGAAAAGCAGAGATGATGTCCCAAAACTAGTGACTGAGTTCCTGGCAAAGAAATTT
GACCTGGACCAGTTGATAACTCATGTTTTACCATTTAAAAAAATCAGTGAAGGATTTGAG
CTGCTCAATTCAGGACAAAGCATTCGAACGGTCCTGACGTTTTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
L33179

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_5_Locus:
4q23-q24

# Metabolic_Enzyme_5_SNPs:
rs1573496; rs971074; rs894369; rs284787; rs3805331; rs3805329; rs284786; rs4147554; rs17029033; rs17537595; rs1154456; rs284784; rs1154460; rs284785; rs2584464; rs1154467; rs1154459; rs4147549; rs1154458; rs2851011; rs1827567; rs1154457; rs12504511; rs284779; rs930478; rs1154461; rs1154455; rs1154454; rs1229797; rs1154464; rs4147553; rs1154469; rs2851297; rs17529377; rs7693230; rs284798; rs17588403; rs17588761; rs17029037; rs1154468; rs3737482; rs17529509; rs12499297; rs2584465; rs4147552; rs17029035; rs12502365; rs12510051; rs17529530; rs1154470; rs729147; rs284789; rs1154453; rs284790; rs2851012; rs4147555; rs2654847; rs1154471; rs284797; rs1042111; rs34907712; rs1154462; rs34061749; rs35268476; rs28418615; rs2866159; rs34652525; rs35672109; rs36008509; rs2866158; rs28712290; rs34555199; rs1154466; rs11480228; rs4147551; rs11359125; rs35475511; rs4147550; rs35065328; rs35006747; rs1154465; rs36166167; rs34553961; rs2860159; rs4318659; rs7690256; rs13137887; rs34682744; rs2851031; rs2866160; rs12502381; rs13146108; rs35816713; rs1154463; rs6831961; rs36084955; rs2851030; rs34925826; rs422143; rs33995120; rs2851028; rs34216119; rs3076141; rs2851296; rs2584463; rs34090033; rs377582; rs1154452; rs284788; rs34457649; rs34867051; rs437106; rs10020840; rs1154472; rs1154473; rs1154474; rs1154475; rs1154476; rs1154477; rs1154480; rs1154481; rs1154483; rs13104075; rs1348276; rs1442477; rs1442488; rs1442489; rs1442490; rs1553434; rs17028991; rs17587689; rs2083687; rs2083688; rs2099855; rs2202291; rs2584462; rs2654848; rs284791; rs284792; rs284793; rs2851295; rs400144; rs4699382; rs7435475; rs7663410; rs7668420; rs7696921; rs969804; rs994771; rs994772

# Metabolic_Enzyme_5_General_References:
8195208; 7876191; 7925371; 8082805; 7876099; 7771649; 1592118; 9228021

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5758

# Metabolic_Enzyme_6_Name:
Alcohol dehydrogenase 4

# Metabolic_Enzyme_6_Synonyms:
Alcohol dehydrogenase class II pi chain

# Metabolic_Enzyme_6_Gene_Name:
ADH4

# Metabolic_Enzyme_6_Protein_Sequence:
>Alcohol dehydrogenase 4
MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEG
LAFPVIVGHE
AAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNL
KSPASDQQLMEDKTSRFTCKG
KPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLL
GCGFSTGYGAAINNAKVTPGSTCAVFGLGGVG
LSAVMGCKAAGASRIIGIDINSEKFVK
AKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSET
MKAALDCTTAGWGSCT
FIGVAAGSKGLTVFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDA
LVTHT
LPFDKISEAFDLMNQGKSIRTILIF

# Metabolic_Enzyme_6_Number_of_Residues:
380

# Metabolic_Enzyme_6_Molecular_Weight:
40222

# Metabolic_Enzyme_6_Theoretical_pI:
8.01

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_6_Specific_Function:
An alcohol + NAD(+) = an aldehyde or ketone + NADH

# Metabolic_Enzyme_6_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_6_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
178121

# Metabolic_Enzyme_6_SwissProt_ID:
ADH4_HUMAN (P08319)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ADH4

# Metabolic_Enzyme_6_Geneatlas_id:
ADH4

# Metabolic_Enzyme_6_hgnc_id:
HGNC:252

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_6_Gene_Sequence:
>1179 bp

ATGGGCACCAAGGGCAAAGTTATTAAATGCAAAGCAGCCATCGCCTGGGAAGCAGGCAA
GCCCCTTTGCA
TTGAAGAGGTTGAAGTAGCTCCCCCCAAGGCTCATGAAGTTCGCATTC
AGATCATTGCTACCTCCCTGTG
CCATACTGATGCCAGTGTTATCGATTCTAAATTTGAG
GGCCTAGCTTTCCCAGTGATCGTTGGCCATGAG
GCTGCAGGTATTGTGGAAAGTATTGG
GCCAGGAGTGACCAACGTCAAACCAGGTGACAAAGTAATTCCAC
TTTATGCACCTCTAT
GTAGAAAATGCAAGTTTTGTCTGAGTCCACTCACAAATTTGTGTGGGAAAATCAG
TAAT
CTCAAAAGTCCTGCTAGTGATCAACAACTAATGGAAGACAAAACCAGCAGGTTTACCTGC
AAAGGA
AAACCAGTTTACCATTTCTTTGGAACCAGTACATTCTCTCAGTACACTGTGGT
GTCAGATATCAATCTTG
CCAAAATAGATGATGATGCAAATTTAGAGAGAGTTTGTCTGC
TTGGATGTGGGTTTTCAACTGGCTATGG
GGCTGCAATCAACAATGCCAAGGTCACCCCT
GGTTCGACTTGTGCTGTCTTTGGCCTAGGAGGTGTGGGT
CTTTCTGCTGTAATGGGTTG
TAAAGCAGCAGGAGCTTCCAGAATCATAGGTATTGACATCAACAGTGAGA
AGTTTGTGA
AGGCTAAAGCCCTGGGAGCCACTGACTGCCTCAATCCTAGAGACTTACATAAACCGATCC
A
GGAAGTTATCATTGAATTGACCAAGGGAGGTGTGGATTTTGCCCTTGACTGTGCAGGT
GGATCTGAAACC
ATGAAAGCAGCCCTGGACTGTACAACCGCAGGCTGGGGATCATGTAC
TTTCATTGGAGTAGCTGCTGGTA
GCAAAGGATTGACTATTTTTCCAGAGGAGCTAATAA
TCGGCCGTACTATAAATGGAACATTCTTTGGTGG
TTGGAAAAGTGTAGATTCTATCCCA
AAGCTGGTCACTGACTATAAGAATAAGAAATTCAATCTGGATGCA
TTGGTGACCCATAC
CCTGCCTTTTGACAAAATCAGTGAGGCATTTGACCTAATGAACCAAGGAAAAAGCG
TCC
GAACAATCCTCATCTTTGGAAGATGCCAGGAGCAATTCAGAATACTATCTGATTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M15943

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_6_Locus:
4q21-q24|4q22

# Metabolic_Enzyme_6_SNPs:
rs1126671; rs1126673; rs1126672; rs1126670; rs2032349; rs1042364; rs1042365; rs10097; rs1139490; rs4148886; rs7672728; rs7670060; rs6532798; rs2032348; rs6532799; rs2602895; rs7670241; rs7694646; rs13110764; rs2851247; rs7694844; rs4699714; rs17217949; rs6813415; rs10017466; rs13108999; rs7689753; rs6532797; rs6831352; rs2602894; rs28987095; rs17817868; rs17817359; rs3805322; rs7670638; rs9307234; rs7669636; rs7692974; rs17817958; rs6820625; rs13143133; rs2851248; rs10009145; rs17218162; rs13133647; rs17218239; rs17218602; rs1984360; rs6837685; rs17218003; rs13110176; rs2851246; rs17218141; rs6855482; rs29001203; rs4699713; rs17218560; rs13133633; rs17218108; rs6822348; rs17218073; rs4699712; rs10026860; rs6848050; rs17218288; rs13138294; rs6848576; rs4699710; rs6836440; rs13148577; rs4148890; rs28987097; rs29001202; rs29001236; rs29001218; rs29001221; rs13140423; rs28987090; rs28987088; rs13132999; rs34936974; rs4502688; rs29001175; rs1540054; rs29001209; rs29001192; rs29001223; rs29001216; rs7691700; rs29001214; rs5860563; rs29001194; rs29001222; rs29001188; rs29001208; rs28987100; rs6840413; rs29001234; rs29001229; rs5860565; rs28987102; rs13112924; rs29001227; rs2602897; rs3919370; rs4148887; rs13132776; rs29001232; rs29001190; rs28987092; rs29001211; rs6532800; rs29001237; rs13106879; rs28987089; rs13113166; rs13133214; rs29001224; rs28987098; rs4699715; rs13125262; rs13112733; rs29001235; rs6840888; rs29001199; rs13133140; rs29001183; rs29001177; rs29001217; rs29001170; rs6841113; rs29001215; rs28987101; rs1573495; rs29001195; rs13129488; rs29001212; rs13112176; rs29001207; rs29001196; rs1984361; rs13102874; rs29001231; rs1984365; rs2213035; rs29001210; rs13108745; rs4148888; rs10712996; rs2602896; rs13107558; rs29001201; rs2602891; rs4148884; rs2226896; rs3762894; rs4148883; rs1800761; rs2851253; rs4140388; rs4699716; rs6858148; rs2924583; rs1800760; rs2851249; rs1800759; rs2851251; rs2213034; rs29001169; rs2851252; rs2851254; rs2602893; rs2602890; rs4699717; rs35229514; rs29001219; rs1139492; rs35490064; rs1139491; rs1139489; rs29001238; rs35073321; rs35760460; rs29001182; rs35767213; rs33933720; rs29001205; rs34876213; rs35652689; rs34071486; rs35019093; rs13127582; rs29001198; rs4699711; rs29001181; rs29001176; rs29001171; rs33927405; rs35882815; rs28987094; rs29001213; rs29001186; rs29001230; rs29001197; rs29001178; rs35786878; rs36034266; rs28987099; rs29001200; rs34805407; rs28816225; rs34338603; rs29001225; rs34360292; rs29001172; rs11728281; rs34069499; rs11732799; rs35062722; rs35774359; rs34118841; rs29001220; rs29001204; rs29001174; rs29001233; rs41275695; rs3049429; rs29001180; rs35385089; rs10711227; rs4148891; rs33955894; rs28987096; rs29001189; rs29001193; rs35108469; rs13127153; rs35784540; rs29001228; rs28987093; rs10014222; rs5860564; rs29001226; rs29001179; rs35205530; rs34295744; rs35406734; rs33977891; rs11724440; rs28987091; rs2156732; rs33958017; rs29001173; rs35518660; rs35246304; rs29001184; rs29001191; rs35662508; rs5860566; rs11317458; rs35988291; rs29001650; rs28973169; rs35283873; rs28542574; rs3049432; rs34851571; rs10648918; rs28987087; rs2851250; rs34634551; rs3049427; rs33970666; rs10678943; rs35146617; rs10032099; rs12649136; rs17028615; rs1984362; rs1984364; rs2156731; rs2602865; rs2602866; rs2602874; rs2602875; rs2602876; rs2602877; rs2602878; rs2602883; rs2602884; rs2602885; rs2602886; rs2851255; rs2851256; rs2851257; rs3828541; rs4235435; rs4235436; rs4699718; rs4699720; rs6532795; rs6532796; rs7434491; rs7698301

# Metabolic_Enzyme_6_General_References:
3036213; 1889753

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
6064

# Metabolic_Enzyme_7_Name:
Alcohol dehydrogenase 1A

# Metabolic_Enzyme_7_Synonyms:
Alcohol dehydrogenase alpha subunit

# Metabolic_Enzyme_7_Gene_Name:
ADH1A

# Metabolic_Enzyme_7_Protein_Sequence:
>Alcohol dehydrogenase 1
AMSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAVGICGTDDHVVSGTMV
TPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLAIPQCGKCRICKNPESNYCLKNDVSN
PQGTLQDGTSRFTCRRKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFST
GYGSAVNVAKVTPGSTCAVFGLGGVGLSAIMGCKAAGAARIIAVDINKDKFAKAKELGAT
ECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDS
QNLSMNPMLLLTGRTWKGAILGGFKSKECVPKLVADFMAKKFSLDALITHVLPFEKINEG
FDLLHSGKSIRTILMF

# Metabolic_Enzyme_7_Number_of_Residues:
375

# Metabolic_Enzyme_7_Molecular_Weight:
39859

# Metabolic_Enzyme_7_Theoretical_pI:
8.02

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_7_Specific_Function:
An alcohol + NAD(+) = an aldehyde or ketone + NADH

# Metabolic_Enzyme_7_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_7_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_7_GenBank_ID_Protein:
178092

# Metabolic_Enzyme_7_SwissProt_ID:
ADH1A_HUMAN (P07327)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
ADH1A

# Metabolic_Enzyme_7_Geneatlas_id:
ADH1A

# Metabolic_Enzyme_7_hgnc_id:
HGNC:249

# Metabolic_Enzyme_7_PDB_ID:
1HSO

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_7_Gene_Sequence:
>1128 bp
ATGAGCACAGCAGGAAAAGTAATCAAATGCAAAGCAGCTGTGCTATGGGAGTTAAAGAAA
CCCTTTTCCATTGAGGAGGTGGAGGTTGCACCTCCTAAGGCCCATGAAGTTCGTATTAAG
ATGGTGGCTGTAGGAATCTGTGGCACAGATGACCACGTGGTTAGTGGTACCATGGTGACC
CCACTTCCTGTGATTTTAGGCCATGAGGCAGCCGGCATCGTGGAGAGTGTTGGAGAAGGG
GTGACTACAGTCAAACCAGGTGATAAAGTCATCCCACTCGCTATTCCTCAGTGTGGAAAA
TGCAGAATTTGTAAAAACCCGGAGAGCAACTACTGCTTGAAAAACGATGTAAGCAATCCT
CAGGGGACCCTGCAGGATGGCACCAGCAGGTTCACCTGCAGGAGGAAGCCCATCCACCAC
TTCCTTGGCATCAGCACCTTCTCACAGTACACAGTGGTGGATGAAAATGCAGTAGCCAAA
ATTGATGCAGCCTCGCCTCTAGAGAAAGTCTGTCTCATTGGCTGTGGATTTTCAACTGGT
TATGGGTCTGCAGTCAATGTTGCCAAGGTCACCCCAGGCTCTACCTGTGCTGTGTTTGGC
CTGGGAGGGGTCGGCCTATCTGCTATTATGGGCTGTAAAGCAGCTGGGGCAGCCAGAATC
ATTGCGGTGGACATCAACAAGGACAAATTTGCAAAGGCCAAAGAGTTGGGGGCCACTGAA
TGCATCAACCCTCAAGACTACAAGAAACCCATCCAGGAGGTGCTAAAGGAAATGACTGAT
GGAGGTGTGGATTTTTCATTTGAAGTCATCGGTCGGCTTGACACCATGATGGCTTCCCTG
TTATGTTGTCATGAGGCATGTGGCACAAGTGTCATCGTAGGGGTACCTCCTGATTCCCAA
AACCTCTCAATGAACCCTATGCTGCTACTGACTGGACGTACCTGGAAGGGAGCTATTCTT
GGTGGCTTTAAAAGTAAAGAATGTGTCCCAAAACTTGTGGCTGATTTTATGGCTAAGAAG
TTTTCATTGGATGCATTAATAACCCATGTTTTACCTTTTGAAAAAATAAATGAAGGATTT
GACCTGCTTCACTCTGGGAAAAGTATCCGTACCATTCTGATGTTTTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
M12271

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_7_Locus:
4q21-q23

# Metabolic_Enzyme_7_SNPs:
rs6828526; rs2866151; rs1229970; rs12504321; rs28364312; rs6835771; rs3805325; rs1229969; rs931635; rs975833; rs1229977; rs3805324; rs13120422; rs2276332; rs3819197; rs1229967; rs4147532; rs28364333; rs1229968; rs28364323; rs33991678; rs28364307; rs28364328; rs1229976; rs28364304; rs28364324; rs28364334; rs28364322; rs28364338; rs28364294; rs28364311; rs28364305; rs28364298; rs28364332; rs28364335; rs28364319; rs28364321; rs28364292; rs28364313; rs28364329; rs28364336; rs28364296; rs4147531; rs12512110; rs1229966; rs13120304; rs7684674; rs17584149; rs28364286; rs6835371; rs28364283; rs28364342; rs13134764; rs28364341; rs28364340; rs28364325; rs28364337; rs28364315; rs10690902; rs28364293; rs34073783; rs4147533; rs28364297; rs28364301; rs28364306; rs28364314; rs35568460; rs28521649; rs28745868; rs28364330; rs13126850; rs28364300; rs28364317; rs28364339; rs28364327; rs12645219; rs13116877; rs1229971; rs28364309; rs28364331; rs2051429; rs12508502; rs12504365; rs28364295; rs28364316; rs35613639; rs34235527; rs28364326; rs12512053; rs28364299; rs28364308; rs28364303; rs28364318; rs35573104; rs33992258; rs5860574; rs28364320; rs34362837; rs6854980; rs28364289; rs28364285; rs35984131; rs34231176; rs5860573; rs35354633; rs11461839; rs28364287; rs28364282; rs28364290; rs2173198; rs28364288; rs28364343; rs28364284; rs28364291; rs1230024; rs12504387; rs13103321; rs13117371; rs13123099; rs13145277; rs17028765; rs17028770; rs2051427; rs6811453; rs6812015; rs6837311; rs904092

# Metabolic_Enzyme_7_General_References:
3013304; 2935875; 2920825; 2347582

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
6065

# Metabolic_Enzyme_8_Name:
Alcohol dehydrogenase 6

# Metabolic_Enzyme_8_Synonyms:
Not Available

# Metabolic_Enzyme_8_Gene_Name:
ADH6

# Metabolic_Enzyme_8_Protein_Sequence:
>Alcohol dehydrogenase 6
MSTTGQVIRCKAAILWKPGAPFSIEEVEVAPPKAKEVRIKVVATGLCGTEMKVLGSKHLD
LLYPTILGHE
GAGIVESIGEGVSTVKPGDKVITLFLPQCGECTSCLNSEGNFCIQFKQS
KTQLMSDGTSRFTCKGKSIYH
FGNTSTFCEYTVIKEISVAKIDAVAPLEKVCLISCGFS
TGFGAAINTAKVTPGSTCAVFGLGGVGLSVVM
GCKAAGAARIIGVDVNKEKFKKAQELG
ATECLNPQDLKKPIQEVLFDMTDAGIDFCFEAIGNLDVLAAAL
ASCNESYGVCVVVGVL
PASVQLKISGQLFFSGRSLKGSVFGGWKSRQHIPKLVADYMAEKLNLDPLITHT
LNLDK
INEAVELMKTGKW

# Metabolic_Enzyme_8_Number_of_Residues:
368

# Metabolic_Enzyme_8_Molecular_Weight:
39073

# Metabolic_Enzyme_8_Theoretical_pI:
7.86

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_8_Specific_Function:
An alcohol + NAD(+) = an aldehyde or ketone + NADH

# Metabolic_Enzyme_8_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_8_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_8_GenBank_ID_Protein:
178146

# Metabolic_Enzyme_8_SwissProt_ID:
ADH6_HUMAN (P28332)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
ADH6

# Metabolic_Enzyme_8_Geneatlas_id:
ADH6

# Metabolic_Enzyme_8_hgnc_id:
HGNC:255

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_8_Gene_Sequence:
>1107 bp

ATGAGTACTACAGGCCAAGTCATCAGATGCAAAGCAGCCATACTCTGGAAGCCTGGTGC
ACCATTTTCTA
TTGAAGAGGTAGAAGTGGCCCCACCAAAGGCAAAGGAGGTTCGCATAA
AGGTTGTGGCCACCGGACTGTG
TGGTACAGAGATGAAAGTGTTGGGGAGTAAACACTTG
GACCTCTTGTATCCCACCATCTTGGGCCATGAA
GGGGCTGGAATCGTTGAGAGTATTGG
AGAAGGAGTAAGCACAGTGAAACCAGGTGACAAAGTTATCACAC
TCTTTCTGCCACAGT
GTGGAGAATGTACCTCTTGCCTGAATTCTGAGGGCAATTTTTGTATACAATTCAA
ACAG
TCAAAAACCCAACTGATGTCTGATGGTACCAGCAGGTTTACCTGCAAGGGAAAATCAATA
TATCAC
TTTGGTAATACCAGCACCTTCTGTGAATACACAGTGATAAAGGAAATCTCAGT
TGCCAAGATTGATGCAG
TCGCTCCTCTAGAGAAAGTATGCCTAATTAGCTGTGGCTTTT
CCACTGGGTTTGGTGCTGCAATCAATAC
TGCCAAGGTGACTCCAGGTTCTACCTGTGCT
GTGTTTGGCCTGGGAGGAGTCGGCTTGTCTGTTGTCATG
GGTTGTAAAGCAGCAGGAGC
AGCCAGGATCATTGGAGTGGATGTCAACAAGGAGAAATTTAAGAAGGCAC
AGGAATTGG
GTGCGACTGAGTGCCTCAACCCTCAGGACTTAAAGAAACCCATTCAAGAAGTTTTATTTG
A
TATGACAGATGCTGGTATAGACTTCTGCTTTGAGGCCATTGGAAATCTGGACGTTCTG
GCAGCTGCCCTC
GCCTCCTGCAATGAGAGCTATGGGGTCTGTGTGGTTGTTGGGGTGTT
GCCTGCCAGTGTTCAACTCAAAA
TCAGTGGCCAGTTGTTCTTCTCAGGACGTTCTTTGA
AGGGTTCTGTTTTTGGAGGCTGGAAGAGCAGACA
GCACATCCCTAAACTGGTTGCTGAT
TATATGGCAGAGAAGTTGAATCTAGATCCACTAATTACTCATACT
CTGAATCTTGATAA
AATCAATGAAGCAGTTGAATTAATGAAAACTGGAAAATGGTAA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
M84402

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_8_Locus:
4q23

# Metabolic_Enzyme_8_SNPs:
rs34582580; rs3857224; rs4147547; rs2156733; rs2187483; rs4147545; rs4699733; rs6833176; rs9307238; rs4147544; rs17219626; rs7692358; rs17219837; rs9995799; rs7661441; rs17028743; rs10030920; rs6820368; rs1893882; rs17028735; rs28891986; rs28720148; rs28720143; rs28720157; rs28720134; rs28720150; rs28720139; rs28720155; rs28891982; rs17028732; rs4699734; rs5860571; rs28891984; rs28720159; rs28720146; rs28720147; rs28891987; rs28720140; rs28720149; rs28891983; rs17028740; rs28720151; rs28891985; rs1893883; rs10008281; rs13104485; rs10002894; rs2866041; rs12507078; rs28720166; rs28720167; rs28720128; rs28720164; rs28720130; rs28720129; rs28720152; rs4699735; rs28720153; rs4147546; rs6843298; rs28720162; rs1893881; rs28720160; rs33918268; rs28720145; rs11097661; rs28720154; rs28720156; rs5860570; rs4147548; rs17028745; rs28720141; rs34347755; rs28720161; rs34008565; rs10026121; rs34584669; rs28720135; rs34587044; rs4283664; rs3049463; rs36016490; rs10025760; rs28720144; rs5860569; rs28720158; rs28720133; rs11097660; rs35632288; rs34273750; rs28720142; rs35482105; rs34686169; rs35230679; rs11305316; rs35171550; rs28720138; rs28720136; rs1130919; rs28720132; rs1130917; rs34932624; rs1130918; rs28720165; rs34713251; rs28720131; rs28720163; rs35371403; rs34274880; rs1130921; rs11733695; rs12510722; rs2000864; rs2051428; rs6532807; rs6814114; rs6828364; rs6830685

# Metabolic_Enzyme_8_General_References:
1881901

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
6066

# Metabolic_Enzyme_9_Name:
Alcohol dehydrogenase 1C

# Metabolic_Enzyme_9_Synonyms:
Alcohol dehydrogenase gamma subunit

# Metabolic_Enzyme_9_Gene_Name:
ADH1C

# Metabolic_Enzyme_9_Protein_Sequence:
>Alcohol dehydrogenase 1
CMSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLV
TPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGN
PRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFST
GYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGAT
ECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDS
QNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNILPFEKINEG
FDLLRSGKSIRTVLTF

# Metabolic_Enzyme_9_Number_of_Residues:
375

# Metabolic_Enzyme_9_Molecular_Weight:
39868

# Metabolic_Enzyme_9_Theoretical_pI:
8.38

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_9_Specific_Function:
An alcohol + NAD(+) = an aldehyde or ketone + NADH

# Metabolic_Enzyme_9_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_9_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_9_GenBank_ID_Protein:
28404

# Metabolic_Enzyme_9_SwissProt_ID:
ADH1G_HUMAN (P00326)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
ADH1C

# Metabolic_Enzyme_9_Geneatlas_id:
ADH1C

# Metabolic_Enzyme_9_hgnc_id:
HGNC:251

# Metabolic_Enzyme_9_PDB_ID:
1HT0

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_9_Gene_Sequence:
>1128 bp
ATGAGCACAGCAGGAAAAGTAATCAAATGCAAAGCAGCTGTGCTATGGGAGTTAAAGAAA
CCCTTTTCCATTGAGGAGGTAGAGGTTGCACCTCCTAAGGCTCATGAAGTTCGCATTAAG
ATGGTGGCTGCAGGAATCTGTCGTTCAGATGAGCATGTGGTTAGTGGCAACCTGGTGACC
CCCCTTCCTGTGATTTTAGGCCATGAGGCAGCCGGCATCGTGGAAAGTGTTGGAGAAGGG
GTGACTACAGTCAAACCAGGTGATAAAGTCATCCCGCTCTTTACTCCTCAGTGTGGAAAA
TGCAGAATTTGCAAAAACCCAGAAAGCAACTACTGCTTGAAAAATGATCTAGGCAATCCT
CGGGGGACCCTGCAGGATGGCACCAGGAGGTTCACCTGCAGCGGGAAGCCCATCCACCAC
TTCGTCGGCGTCAGCACCTTCTCCCAGTACACAGTGGTGGATGAGAATGCAGTAGCCAAA
ATTGATGCAGCCTCGCCCCTGGAGAAAGTCTGCCTCATTGGCTGTGGATTTTCGACTGGT
TATGGGTCTGCAGTCAAAGTTGCCAAGGTCACCCCAGGGTCTACCTGTGCTGTGTTTGGC
CTGGGAGGGGTCGGCCTATCTGTTGTTATGGGCTGTAAAGCAGCTGGAGCAGCCAGAATC
ATTGCTGTGGACATCAACAAGGACAAATTTGCAAAGGCTAAAGAGTTGGGTGCCACTGAA
TGCATCAACCCTCAAGACTACAAGAAACCCATTCAGGAAGTGCTAAAGGAAATGACTGAT
GGAGGTGTGGATTTTTCGTTTGAAGTCATCGGTCAGCTTGACACCATGATGGCTTCCCTG
TTATGTTGTCATGAGGCATGTGGCACAAGTGTCATTGTAGGGGTACCTCCTGATTCCCAG
AACCTCTCAATAAACCCTATGCTGCTACTGACTGGACGCACGTGGAAAGGAGCTATTTTT
GGAGGCTTTAAGAGTAAAGAATCTGTCCCCAAACTTGTGGCTGACTTTATGGCTAAGAAG
TTTTCACTGGATGCATTAATAACAAATGTTTTACCTTTTGAAAAAATAAATGAAGGATTT
GACCTGCTTCGCTCTGGAAAGAGTATCCGTACCGTCCTGACGTTTTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
X04299

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_9_Locus:
4q21-q23

# Metabolic_Enzyme_9_SNPs:
rs35385902; rs35719513; rs1693482; rs698; rs2241894; rs6413444; rs1042756; rs1693425; rs1789915; rs2298753; rs1391088; rs904096; rs1789911; rs1614972; rs1789898; rs1612735; rs1789921; rs3762896; rs3846449; rs283415; rs4147542; rs1789910; rs3133158; rs11936869; rs1789912; rs1442481; rs33988198; rs17586023; rs1662058; rs1662051; rs1789908; rs2298755; rs17526590; rs1789903; rs1662048; rs1789900; rs1662057; rs1693481; rs904095; rs6846835; rs1662060; rs1789920; rs6413446; rs1662049; rs1693480; rs6532815; rs1442479; rs1693427; rs35429031; rs1693453; rs13125415; rs1693476; rs6413447; rs12650330; rs1789901; rs35862892; rs3114047; rs1693471; rs283409; rs34009511; rs1662047; rs2009181; rs1789923; rs35500540; rs6413445; rs35189763; rs36050634; rs1789902; rs1693428; rs1625439; rs3114048; rs283411; rs34178057; rs34484723; rs6413448; rs35408712; rs35799067; rs283410; rs34250750; rs34551784; rs1662052; rs1662033; rs1662059; rs1662045; rs34736030; rs34664835; rs1693426; rs1442480; rs1693431; rs1789904; rs3910713; rs1693424; rs12639833; rs1662053; rs1693477; rs35221936; rs34871400; rs283416; rs1662046; rs34317813; rs34761493; rs2866153; rs1631460; rs904094; rs1693454; rs1789896; rs3114046; rs1229979; rs3098808; rs1662031; rs11499825; rs1789924; rs17028860; rs11499824; rs17586163; rs11499823; rs35963940; rs1693468; rs4147541; rs1789925; rs34436992; rs36024187; rs2584453; rs35365756; rs1629838; rs1789895; rs35478916; rs35614967; rs1693469; rs1229978; rs283413; rs34195308; rs35725608; rs2132839; rs2851298; rs1789919; rs36019411; rs1693483; rs6834363; rs34427956; rs35124782; rs33982136; rs904093; rs35088274; rs7658726; rs2298754; rs1662055; rs35191371; rs34918164; rs1789905; rs3133157; rs35090494; rs35470995; rs34661405; rs13118501; rs1693456; rs35418122; rs34057349; rs2903199; rs36052336; rs2851299; rs13118443; rs3216150; rs1975438; rs13147169; rs35920708; rs1662056; rs34579771; rs1789917; rs34804188; rs1789906; rs2132838; rs35081954; rs13147189; rs35381492; rs1693430; rs1693429; rs1693474; rs3960879; rs10634918; rs35735210; rs6148597; rs34782639; rs1629270; rs283414; rs1789914; rs1789916; rs35733876; rs34936799; rs35420886; rs34379379; rs1662035; rs6148596; rs283412; rs172223; rs1789913; rs5860576; rs35801274; rs34480181; rs3098809; rs35293095; rs1662030; rs36095748; rs34774688; rs1662032; rs35691997; rs35978141; rs34328535; rs34484557; rs1154432; rs1154433; rs1229851; rs1229852; rs1229853; rs1229854; rs1229863; rs1229864; rs1229980; rs1614377; rs1662037; rs1662039; rs166892; rs1693470; rs17586246; rs1789890; rs1789891; rs2584455; rs2851300; rs2866152; rs4699741; rs980972

# Metabolic_Enzyme_9_General_References:
3758060; 2935875; 1524834; 6391921

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5977

# Metabolic_Enzyme_10_Name:
Adenylate cyclase type 7

# Metabolic_Enzyme_10_Synonyms:
Adenylate cyclase type VII; ATP pyrophosphate-lyase 7; Adenylyl cyclase 7

# Metabolic_Enzyme_10_Gene_Name:
ADCY7

# Metabolic_Enzyme_10_Protein_Sequence:
>Adenylate cyclase type 7
MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPS
RHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAA
CAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQL
LANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAH
ISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKEL
VVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQ
VREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT
LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRA
SVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRS
EDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACA
SLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISER
VETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLP
YYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKP
NGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFET
MENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKE
GLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAH
IGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVAS
RMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN


# Metabolic_Enzyme_10_Number_of_Residues:
1080

# Metabolic_Enzyme_10_Molecular_Weight:
120310

# Metabolic_Enzyme_10_Theoretical_pI:
8.16

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  cyclase activity
Function:  adenylate cyclase activity
Function:  catalytic activity
Function:  lyase activity
Function:  phosphorus-oxygen lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  cyclic nucleotide biosynthesis
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Metabolic_Enzyme_10_General_Function:
Signal transduction mechanisms 

# Metabolic_Enzyme_10_Specific_Function:
This is a membrane-bound, calcium-inhibitable adenylyl cyclase

# Metabolic_Enzyme_10_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_10_Reaction:
ATP = 3',5'-cyclic AMP + diphosphate

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF06327:DUF1053;
PF00211:Guanylate_cyc

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
34-54
63-83
95-117
122-142
147-167
176-196
595-615
620-640
669-688
718-737
746-773
794-814

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 4.6.1.1

# Metabolic_Enzyme_10_GenBank_ID_Protein:
40788941

# Metabolic_Enzyme_10_SwissProt_ID:
ADCY7_HUMAN (P51828)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
ADCY7

# Metabolic_Enzyme_10_Geneatlas_id:
ADCY7

# Metabolic_Enzyme_10_hgnc_id:
HGNC:238

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Membrane; multi-pass membrane protein

# Metabolic_Enzyme_10_Gene_Sequence:
>3267 bp
CGACACGCGTGCCAAGGGTGGAGGATGCCAGCCAAGGGGCGCTACTTCCTCAACGAGGGC
GAGGAGGGCCCTGACCAAGATGCGCTCTACGAGAAGTACCAGCTCACCAGCCAGCATGGG
CCGCTGCTGCTCACGCTCCTGCTGGTGGCCGCCACTGCCTGCGTGGCCCTCATCATCATT
GCCTTCAGCCAGGGGGACCCCTCCAGACACCAGGCCATTCTGGGCATGGCGTTCCTGGTG
CTGGCGGTGTTTGCGGCCCTCTCTGTGCTGATGTACGTCGAGTGTCTCCTGCGGCGCTGG
CTCAGGGCCTTGGCGCTGCTCACCTGGGCCTGCTTGGTGGCGCTGGGCTATGTGCTGGTG
TTCGACGCATGGACAAAGGCGGCCTGTGCGTGGGAGCAGGTGCCCTTCTTCCTGTTCATT
GTCTTCGTGGTGTACACACTACTGCCCTTCAGCATGCGGGGCGCTGTCGCCGTTGGGGCC
GTCTCCACTGCCTCCCACCTCCTGGTGCTCGGTTCTTTGATGGGAGGCTTCACGACACCC
AGTGTCCGGGTGGGGCTGCAGCTGCTGGCCAACGCAGTCATCTTCCTGTGTGGGAACCTG
ACAGGCGCCTTCCACAAGCACCAAATGCAGGATGCGTCCCGGGACCTCTTCACCTACACT
GTGAAGTGCATCCAGATCCGCCGGAAGCTGCGCATCGAGAAGCGCCAGCAGGAGAACCTG
CTGCTGTCAGTGCTTCCGGCCCACATCTCCATGGGCATGAAGCTGGCCATCATCGAACGG
CTCAAGGAGCATGGTGACCGTCGCTGCATGCCTGACAACAACTTCCACAGCCTCTACGTC
AAGAGGCACCAGAATGTCAGCATCCTCTATGCGGACATCGTGGGCTTCACGCAGCTGGCC
AGCGACTGTTCTCCCAAGGAGCTGGTGGTGGTGCTGAATGAGCTCTTTGGCAAGTTCGAC
CAGATCGCCAAGGCCAACGAGTGCATGCGAATCAAGATCCTCGGCGACTGCTACTACTGT
GTATCGGGCCTGCCCGTGTCGCTGCCTACCCACGCCCGGAACTGCGTGAAGATGGGGCTG
GACATGTGCCAGGCCATCAAGCAGGTGCGGGAGGCCACGGGCGTGGACATCAACATGCGT
GTGGGCATACACTCGGGGAATGTGCTGTGCGGGGTCATCGGGCTGCGCAAGTGGCAGTAT
GACGTGTGGTCCCACGACGTGTCCCTGGCCAACCGGATGGAGGCAGCCGGAGTACCCGGC
CGGGTGCACATCACGGAGGCCACGCTAAAGCACCTGGACAAGGCGTACGAGGTGGAGGAT
GGGCACGGGCAGCAGCGGGACCCCTACCTCAAGGAGATGAACATCCGCACCTACCTGGTC
ATCGACCCCCGGAGCCAGCAGCCACCCCCGCCCAGCCAACACCTCCCCAGGCCCAAGGGG
GACGCGGCCCTGAAGATGCGGGCGTCAGTGCGCATGACCCGGTACCTCGAGTCCTGGGGG
GCGGCACGGCCCTTTGCACATCTCAACCACCGTGAGAGCGTGAGCAGTGGTGAGACCCAC
GTCCCCAACGGGCGGAGGCCTAAGAGCGTTCCCCAGCGCCACCGCCGGACCCCAGACAGA
AGCATGTCCCCCAAGGGGCGGTCGGAGGATGACTCGTACGATGACGAGATGCTGTCAGCC
ATTGAGGGGCTCAGCTCCACGAGGCCCTGCTGCTCCAAGTCCGATGACTTCTACACCTTT
GGGTCCATCTTCCTGGAGAAGGGCTTTGAGCGCGAGTACCGCCTGGCACCCATCCCCCGG
GCCCGCCACGACTTTGCCTGCGCCAGCCTGATCTTCGTCTGCATCCTGCTCGTCCATGTC
CTGCTCATGCCCAGGACGGCGGCACTGGGTGTGTCCTTCGGGCTGGTGGCCTGTGTACTG
GGGCTGGTGCTGGGCCTGTGCTTTGCCACCAAGTTCTCGAGGTGCTGCCCAGCTCGGGGG
ACGCTCTGCACTATCTCTGAGAGGGTGGAGACACAGCCCCTGCTGAGGCTGACCCTGGCC
GTCCTGACCATCGGCAGCCTGCTCACTGTGGCCATCATCAACCTGCCCCTGATGCCTTTC
CAAGTTCCAGAGCTGCCTGTTGGCAATGAGACAGGCCTACTGGCCGCGAGCAGCAAGACA
AGAGCCCTGTGTGAGCCCCTCCCGTACTACACCTGCAGCTGTGTCCTGGGCTTCATCGCC
TGCTCGGTCTTCCTGAGGATGAGCCTGGAGCCAAAGGTTGTGCTGCTGACAGTGGCCCTG
GTGGCCTACCTGGTGCTCTTCAACCTCTCCCCATGCTGGCAGTGGGACTGCTGCGGCCAA
GGCCTGGGCAACCTCACCAAGCCCAACGGCACCACCAGTGGCACCCCTAGCTGTTCCTGG
AAGGACCTGAAGACCATGACCAATTTCTACCTGGTCCTGTTCTACATCACCCTGCTTACA
CTCTCCAGACAGATTGACTATTACTGCCGCTTGGACTGCCTATGGAAGAAGAAGTTCAAG
AAGGAGCACGAGGAGTTTGAGACCATGGAGAACGTGAACCGCCTTCTTCTGGAGAACGTC
CTGCCAGCCCACGTGGCTGCCCACTTTATCGGTGACAAGTTAAACGAGGACTGGTACCAT
CAGTCCTATGACTGCGTCTGTGTCATGTTTGCCTCCGTGCCGGACTTCAAAGTGTTCTAC
ACAGAGTGCGATGTCAACAAAGAAGGGCTGGAGTGCCTACGCCTGCTCAATGAGATCATT
GCCGACTTCGACGAGCTCCTACTGAAGCCCAAGTTCAGCGGCGTGGAGAAGATCAAGACC
ATCGGCAGCACGTACATGGCAGCTGCAGGGCTCAGCGTCGCCTCAGGGCACGAGAACCAG
GAGCTGGAGCGGCAGCATGCCCACATTGGTGTCATGGTGGAGTTCAGCATCGCCCTGATG
AGTAAGCTGGACGGCATCAACAGGCACTCCTTCAACTCCTTCCGCCTCCGCGTCGGCATA
AACCATGGGCCTGTGATTGCTGGAGTGATTGGGGCCCGAAAACCTCAGTATGACATCTGG
GGAAACACTGTCAATGTGGCCAGCCGAATGGAAAGCACTGGAGAACTTGGGAAAATCCAG
GTTACCGAGGAGACCTGCACCATCCTCCAGGGCCTCGGGTACTCTTGTGAATGCCGTGGC
CTGATCAACGTCAAAGGCAAAGGCGAGCTGAGGACTTACTTTGTCTGTACGGACACTGCC
AAGTTTCAGGGGCTGGGGCTGAACTGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
D25538

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_10_Locus:
16q12-q13

# Metabolic_Enzyme_10_SNPs:
rs17289102; rs11861332; rs1064448; rs1872691; rs11644926; rs1540624; rs2302681; rs8052384; rs9939322; rs4785211; rs9936021; rs4785403; rs8061123; rs9926131; rs7191958; rs4785210; rs4785402; rs3813755; rs729229; rs2302712; rs11649380; rs9924714; rs8045659; rs8049122; rs2302680; rs7193839; rs11648839; rs7193875; rs2302717; rs2302715; rs12445243; rs11859417; rs728962; rs2302716; rs11861597; rs7202127; rs7186882; rs12444679; rs8056293; rs3833062; rs2302679; rs9927261; rs8060642; rs4082435; rs3826173; rs3892156; rs3760012; rs3760011; rs28514808; rs7359472; rs2230664; rs1064447; rs8051594; rs35787328; rs10589177; rs9940992; rs4785407; rs12918980; rs12444266; rs7500891; rs5816686; rs35969283; rs34860956; rs34493825; rs9937781; rs35262781; rs2302678; rs13332825; rs12932721; rs34996336; rs2302714; rs11640409; rs12932722; rs16948389; rs34039653; rs28510819; rs28432797; rs3841348; rs3214383; rs3815562; rs35078746; rs34191947; rs11403746; rs4502213; rs34381393; rs7197662; rs35284914; rs28403987; rs2302713; rs12919306; rs35003370; rs35732926; rs35829985; rs34216705; rs11352304; rs10577557; rs12444236; rs12924307; rs12598249; rs11417859; rs12443620; rs8048743; rs34009001; rs34686094; rs8053067; rs1078151; rs11644043; rs11645133; rs11649621; rs11860192; rs17216076; rs1872688; rs34176129; rs3760013; rs3760014; rs4497684; rs4785401; rs4785408; rs7184476; rs7184802; rs7196135; rs7204026; rs751127; rs8046783; rs8057103; rs8061808; rs9922362; rs9926720; rs9937029; rs9940619

# Metabolic_Enzyme_10_General_References:
7584026

# Metabolic_Enzyme_10_References:
17144904

# Macromolecular_Interacting_Partner_1_ID:
7197

# Macromolecular_Interacting_Partner_1_Name:
Corticotropin-lipotropin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Pro-opiomelanocortin; POMC[Contains: NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin]

# Macromolecular_Interacting_Partner_1_Gene_Name:
POMC

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Corticotropinlipotropin precursor
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
267

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
29424

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Beta-endorphin and Met-enkephalin are endogenous opiates

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00976:ACTH_domain;
PF08384:NPP;
PF08035:Op_neuropeptide

# Macromolecular_Interacting_Partner_1_Signals:
1-26

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
190188

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
COLI_HUMAN (P01189)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
POMC

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
POMC

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9201

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>789 bp
TGCAGCCGCTCGGGGGCCCTGTTGCTGGCCTTGCTGCTTCAGGCCTCCATGGAAGTGCGT
GGCTGGTGCCTGGAGAGCAGCCAGTGTCAGGACCTCACCACGGAAAGCAACCTGCTGGAG
TGCATCCGGGCCTGCAAGCCCGACCTCTCGGCCGAGACTCCCATGTTCCCGGGAAATGGC
GACGAGCAGCCTCTGACCGAGAACCCCCGGAAGTACGTCATGGGCCACTTCCGCTGGGAC
CGATTCGGCCGCCGCAACAGCAGCAGCAGCGGCAGCAGCGGCGCAGGGCAGAAGCGCGAG
GACGTCTCAGCGGGCGAAGACTGCGGCCCGCTGCCTGAGGGCGGCCCCGAGCCCCGCAGC
GATGGTGCCAAGCCGGGCCCGCGCGAGGGCAAGCGCTCCTACTCCATGGAGCACTTCCGC
TGGGGCAAGCCGGTGGGCAAGAAGCGGCGCCCAGTGAAGGTGTACCCTAACGGCGCCGAG
GACGAGTCGGCCGAGGCCTTCCCCCTGGAGTTCAAGAGGGAGCTGACTGGCCAGCGACTC
CGGGAGGGAGATGGCCCCGACGGCCCTGCCGATGACGGCGCAGGGGCCCAGGCCGACCTG
GAGCACAGCCTGCTGGTGGCGGCCGAGAAGAAGGACGAGGGCCCCTACAGGATGGAGCAC
TTCCGCTGGGGCAGCCCGCCCAAGGACAAGCGCTACGGCGGTTTCATGACCTCCGAGAAG
AGCCAGACGCCCCTGGTGACGCTGTTCAAAAACGCCATCATCAAGAACGCCTACAAGAAG
GGCGAGTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M38297

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_1_Locus:
2p23.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs28932472; rs8192606; rs28932471; rs35254395; rs8192605; rs28930368; rs2071345; rs34650613; rs1042571; rs11679531; rs6713532; rs7565877; rs6713396; rs12473543; rs6756695; rs6545975; rs6756566; rs28932474; rs28932476; rs28932475; rs28932473; rs10654394; rs28932470; rs3039380; rs35411223; rs35023083; rs33950052; rs7591899; rs15461; rs2071344; rs13388660; rs9973478; rs11353932; rs13404336; rs7565427; rs34619618; rs8192607; rs35639116; rs34526166; rs10188864; rs10195561; rs11892647; rs12472851; rs13418937; rs17046887; rs17046891; rs1866146; rs2071343; rs2118404; rs2164808; rs3769671; rs3795955; rs3820935; rs6545976; rs6719226; rs6734859; rs7589318; rs7605927; rs934778

# Macromolecular_Interacting_Partner_1_General_References:
6274691; 6299668; 6314261; 3606677; 6254047; 6945581; 6267033; 6272808; 4352834; 4334191; 4338630; 4347148; 1264228; 195688; 2424570; 2839146; 7828531; 9768693; 10193875; 11244459

# Macromolecular_Interacting_Partner_1_References:
16435314; 16934232; 17062929

# Macromolecular_Interacting_Partner_2_ID:
7546

# Macromolecular_Interacting_Partner_2_Name:
Prolactin precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
PRL

# Macromolecular_Interacting_Partner_2_Gene_Name:
PRL

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Prolactin precursor
MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN
EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG
LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
227

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
25876

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.99

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Prolactin acts primarily on the mammary gland by promoting lactation

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_2_Signals:
1-28

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
34211

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
PRL_HUMAN (P01236)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
PRL

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
PRL

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:9445

# Macromolecular_Interacting_Partner_2_PDB_ID:
1RW5

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>684 bp
ATGAACATCAAAGGATCGCCATGGAAAGGGTCCCTCCTGCTGCTGCTGGTGTCAAACCTG
CTGCTGTGCCAGAGCGTGGCCCCCTTGCCCATCTGTCCCGGCGGGGCTGCCCGATGCCAG
GTGACCCTTCGAGACCTGTTTGACCGCGCCGTCGTCCTGTCCCACTACATCCATAACCTC
TCCTCAGAAATGTTCAGCGAATTCGATAAACGGTATACCCATGGCCGGGGGTTCATTACC
AAGGCCATCAACAGCTGCCACACTTCTTCCCTTGCCACCCCCGAAGACAAGGAGCAAGCC
CAACAGATGAATCAAAAAGACTTTCTGAGCCTGATAGTCAGCATATTGCGATCCTGGAAT
GAGCCTCTGTATCATCTGGTCACGGAAGTACGTGGTATGCAAGAAGCCCCGGAGGCTATC
CTATCCAAAGCTGTAGAGATTGAGGAGCAAACCAAACGGCTTCTAGAGGGCATGGAGCTG
ATAGTCAGCCAGGTTCATCCTGAAACCAAAGAAAATGAGATCTACCCTGTCTGGTCGGGA
CTTCCATCCCTGCAGATGGCTGATGAAGAGTCTCGCCTTTCTGCTTATTATAACCTGCTC
CACTGCCTACGCAGGGATTCACATAAAATCGACAATTATCTCAAGCTCCTGAAGTGCCGA
ATCATCCACAACAACAACTGCTAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00566

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_2_Locus:
6p22.2-p21.3

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
6260780; 6325171; 2050267; 6146607; 9266104; 925136; 1126929

# Macromolecular_Interacting_Partner_2_References:
16677614; 16682806; 16930771

# Macromolecular_Interacting_Partner_3_ID:
7549

# Macromolecular_Interacting_Partner_3_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
INS

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_3_Signals:
1-24

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
INS

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11p15.5

# Macromolecular_Interacting_Partner_3_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_3_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_3_References:
16447058; 16604089; 16819942; 16890252

# Macromolecular_Interacting_Partner_4_ID:
7552

# Macromolecular_Interacting_Partner_4_Name:
Interferon gamma precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
IFN-gamma; Immune interferon

# Macromolecular_Interacting_Partner_4_Gene_Name:
IFNG

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Interferon gamma precursor
MKYTSYILAFQLCIVLGSLGCYCQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWK
EESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTN
YSVTDLNVQRKAIHELIQVMAELSPAAKTGKRKRSQMLFRGRRASQ

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
166

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
19349

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
10.01

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interferon-gamma receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00714:IFN-gamma

# Macromolecular_Interacting_Partner_4_Signals:
1-23

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
32692

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
IFNG_HUMAN (P01579)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
IFNG

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
IFNG

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:5438

# Macromolecular_Interacting_Partner_4_PDB_ID:
1HIG

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>501 bp
ATGAAATATACAAGTTATATCTTGGCTTTTCAGCTCTGCATCGTTTTGGGTTCTCTTGGC
TGTTACTGCCAGGACCCATATGTAAAAGAAGCAGAAAACCTTAAGAAATATTTTAATGCA
GGTCATTCAGATGTAGCGGATAATGGAACTCTTTTCTTAGGCATTTTGAAGAATTGGAAA
GAGGAGAGTGACAGAAAAATAATGCAGAGCCAAATTGTCTCCTTTTACTTCAAACTTTTT
AAAAACTTTAAAGATGACCAGAGCATCCAAAAGAGTGTGGAGACCATCAAGGAAGACATG
AATGTCAAGTTTTTCAATAGCAACAAAAAGAAACGAGATGACTTCGAAAAGCTGACTAAT
TATTCGGTAACTGACTTGAATGTCCAACGCAAAGCAATACATGAACTCATCCAAGTGATG
GCTGAACTGTCGCCAGCAGCTAAAACAGGGAAGCGAAAAAGGAGTCAGATGCTGTTTCAA
GGTCGAAGAGCATCCCAGTAA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
X13274

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_4_Locus:
12q14

# Macromolecular_Interacting_Partner_4_SNPs:
rs2069723; rs2069734; rs2069722; rs2234687; rs1042274; rs2069721; rs2069718; rs1861493; rs2069719; rs2069714; rs2069716; rs2069720; rs1861494; rs2069713; rs2069717; rs9282708; rs2234685; rs3087272; rs2069715; rs2069733; rs2430561; rs2193049; rs2069728; rs2069705; rs2069724; rs2069731; rs2193050; rs2069725; rs2069709; rs3181034; rs2069727; rs2069736; rs2069707; rs7956940; rs7956720; rs2069706; rs2069732; rs9282709; rs2069729; rs2069726; rs2069730; rs2069710; rs7957366; rs35040375; rs35314021; rs34079299; rs2069712; rs10611634; rs2234686; rs34399538; rs2069711; rs28910281; rs10599707; rs35008976; rs35994963; rs2069737; rs35751061; rs7956688; rs2069735; rs35815094; rs3814242; rs4394909; rs2069708; rs10878762; rs10878763; rs11177072; rs11177073; rs11177074; rs11831576; rs12306852; rs12366912; rs12369470; rs2098395; rs2111059; rs2870953; rs3181032; rs3181033; rs3181035; rs6421227; rs6581791; rs6581794; rs6581795; rs7138107; rs7139169; rs7298719; rs7302488; rs7350604; rs7968411; rs7969745

# Macromolecular_Interacting_Partner_4_General_References:
6180322; 6173769; 2860101; 6329718; 6176945; 6427223; 3109913; 2504704; 1902591; 7617032; 10860730; 1525157

# Macromolecular_Interacting_Partner_4_References:
16670301; 16951320; 16987553

# Macromolecular_Interacting_Partner_5_ID:
7574

# Macromolecular_Interacting_Partner_5_Name:
Cholecystokinins precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
CCK[Contains: Cholecystokinin 58; CCK58; Cholecystokinin 39; CCK39; Cholecystokinin 33; CCK33; Cholecystokinin 12; CCK12; Cholecystokinin 8; CCK8]

# Macromolecular_Interacting_Partner_5_Gene_Name:
CCK

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Cholecystokinins precursor
MNSGVCLCVLMAVLAAGALTQPVPPADPAGSGLQRAEEAPRRQLRVSQRTDGESRAHLGA
LLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDFGRRSAEEYEYPS

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
115

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
12670

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
9.22

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00918:Gastrin

# Macromolecular_Interacting_Partner_5_Signals:
1-20

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
179996

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
CCKN_HUMAN (P06307)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
CCK

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
CCK

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:1569

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>348 bp
ATGAACAGCGGCGTGTGCCTGTGCGTGCTGATGGCGGTACTGGCGGCTGGCGCCCTGACG
CAGCCGGTGCCTCCCGCAGATCCCGCGGGCTCCGGGCTGCAGCGGGCAGAGGAGGCGCCC
CGTAGGCAGCTGAGGGTATCGCAGAGAACGGATGGCGAGTCCCGAGCGCACCTGGGCGCC
CTGCTGGCAAGATACATCCAGCAGGCCCGGAAAGCTCCTTCTGGACGAATGTCCATCGTT
AAGAACCTGCAGAACCTGGACCCCAGCCACAGGATAAGTGACCGGGACTACATGGGCTGG
ATGGATTTTGGCCGTCGCAGTGCCGAGGAGTATGAGTACCCCTCCTAG

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
L00354

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_5_Locus:
3p22-p21.3

# Macromolecular_Interacting_Partner_5_SNPs:
rs3774395; rs754635; rs747456; rs1799923; rs747455; rs8192473; rs2241996; rs6784327; rs6762874; rs11571844; rs2241997; rs11571876; rs11571846; rs11571843; rs11571847; rs1868522; rs4377469; rs8192472; rs10865918; rs2278794; rs4602358; rs11129949; rs11571857; rs11571855; rs11571851; rs3774396; rs11571864; rs11571866; rs11571863; rs11571875; rs7616571; rs11571867; rs11571871; rs11571856; rs11571849; rs11571853; rs10865917; rs11129948; rs11571877; rs11571888; rs11571878; rs11571842; rs11571884; rs11571887; rs11571882; rs11571880; rs11571841; rs3806691; rs11571838; rs11571879; rs11571848; rs11559016; rs1050815; rs11571845; rs3774394; rs11328368; rs4634088; rs34621311; rs11571859; rs11298401; rs11345711; rs11571873; rs11571862; rs4266164; rs11571865; rs11571852; rs11571860; rs11571858; rs11571872; rs11571869; rs11571854; rs11571874; rs11571861; rs35155419; rs7371919; rs11571870; rs11571868; rs11571881; rs11571886; rs34853186; rs11571839; rs11571840; rs11571883; rs35292864; rs11571885; rs10460960; rs11129946; rs11129947; rs11129950; rs12493571; rs13069836; rs17071699; rs17071704; rs17071771; rs1867020; rs1868520; rs1868521; rs2029127; rs4450782; rs4488805; rs4533619; rs6605331; rs6786615; rs7615049; rs7621531; rs7628785; rs7628795; rs9311317; rs935111; rs935112; rs9682785; rs9757702; rs9813346; rs9835027

# Macromolecular_Interacting_Partner_5_General_References:
3856870; 11076522

# Macromolecular_Interacting_Partner_5_References:
16455686; 16718782; 16769038

# Macromolecular_Interacting_Partner_6_ID:
7431

# Macromolecular_Interacting_Partner_6_Name:
Protachykinin 1 precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
PPT[Contains: Substance P; Neurokinin A; NKA; Substance K; Neuromedin L; Neuropeptide K; NPK; Neuropeptide gamma; C-terminal-flanking peptide]

# Macromolecular_Interacting_Partner_6_Gene_Name:
TAC1

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Protachykinin 1 precursor
MKILVALAVFFLVSTQLFAEEIGANDDLNYWSDWYDSDQIKEELPEPFEHLLQRIARRPK
PQQFFGLMGKRDADSSIEKQVALLKALYGHGQISHKRHKTDSFVGLMGKRALNSVAYERS
AMQNYERRR

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
129

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
15003

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
9.38

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cell-cell signaling
Process:  transmission of nerve impulse
Process:  synaptic transmission
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
Process:  tachykinin signaling pathway
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF02202:Tachykinin

# Macromolecular_Interacting_Partner_6_Signals:
1-19

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
29483

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
TKN1_HUMAN (P20366)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
TAC1

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
TAC1

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:11517

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>390 bp
ATGAAAATCCTCGTGGCCTTGGCAGTCTTTTTTCTTGTCTCCACTCAGCTGTTTGCAGAA
GAAATAGGAGCCAATGATGATCTGAATTACTGGTCCGACTGGTACGACAGCGACCAGATC
AAGGAGGAACTGCCGGAGCCCTTTGAGCATCTTCTGCAGAGAATCGCCCGGAGACCCAAG
CCTCAGCAGTTCTTTGGATTAATGGGCAAACGGGATGCTGATTCCTCAATTGAAAAACAA
GTGGCCCTGTTAAAGGCTCTTTATGGACATGGCCAGATCTCTCACAAAAGACATAAAACA
GATTCCTTTGTTGGACTAATGGGCAAAAGAGCTTTAAATTCTGTGGCTTATGAAAGGAGT
GCAATGCAGAATTATGAAAGAAGACGTTAA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
X54469

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_6_Locus:
7q21-q22

# Macromolecular_Interacting_Partner_6_SNPs:
rs2072100; rs12532490; rs12534885; rs4602814; rs1229434; rs1397202; rs4526299; rs2072099; rs3779470; rs4598190; rs7795107; rs1510300; rs11974592; rs2051794; rs7793277; rs17169049; rs11554502; rs6971011; rs11554503; rs6971427; rs1802867; rs15575; rs34326418; rs34707813; rs28740842; rs2189306; rs28475844; rs3058356; rs10602908; rs28674851; rs5886042; rs34560734; rs11320559; rs10247565; rs1229438; rs1229440; rs1237992; rs13232655; rs1510302; rs1510303; rs6465606; rs6465608; rs6945396; rs6962048

# Macromolecular_Interacting_Partner_6_General_References:
3770210; 1708336; 3038549; 2284201

# Macromolecular_Interacting_Partner_6_References:
16489368; 16616214

# Macromolecular_Interacting_Partner_7_ID:
5846

# Macromolecular_Interacting_Partner_7_Name:
Tryptophanyl-tRNA synthetase, cytoplasmic

# Macromolecular_Interacting_Partner_7_Synonyms:
Tryptophan-- tRNA ligase; TrpRS; IFP53; hWRS

# Macromolecular_Interacting_Partner_7_Gene_Name:
WARS

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>TryptophanyltRNA synthetase, cytoplasmic
MPNSEPASLLELFNSIATQGELVRSLKAGNASKDEIDSAVKMLVSLKMSYKAAAGEDYKA
DCPPGNPAPTSNHGPDATEAEEDFVDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELINRI
ERATGQRPHHFLRRGIFFSHRDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFT
KWLQDVFNVPLVIQMTDDEKYLWKDLTLDQAYSYAVENAKDIIACGFDINKTFIFSDLDY
MGMSSGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDR
TDIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIF
LTDTAKQIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQIRKDY
TSGAMLTGELKKALIEVLQPLIAEHQARRKEVTDEIVKEFMTPRKLSFDFQ

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
471

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
53166

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.15

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  tryptophan-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  tryptophanyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_7_Specific_Function:
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)

# Macromolecular_Interacting_Partner_7_Pathway:
map00380  Tryptophan metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Macromolecular_Interacting_Partner_7_Reaction:
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00579:tRNA-synt_1b;
PF00458:WHEP-TRS

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
EC 6.1.1.2

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
184657

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
SYWC_HUMAN (P23381)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
WARS

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
WARS

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:12729

# Macromolecular_Interacting_Partner_7_PDB_ID:
1R6T

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1416 bp
ATGCCCAACAGTGAGCCCGCATCTCTGCTGGAGCTGTTCAACAGCATCGCCACACAAGGG
GAGCTCGTAAGGTCCCTCAAAGCGGGAAATGCGTCAAAGGATGAAATTGATTCTGCAGTA
AAGATGTTGGTGTCATTAAAAATGAGCTACAAAGCTGCCGCGGGGGAGGATTACAAGGCT
GACTGTCCTCCAGGGAACCCAGCACCTACCAGTAATCATGGCCCAGATGCCACAGAAGCT
GAAGAGGATTTTGTGGACCCATGGACAGTACAGACAAGCAGTGCAAAAGGCATAGACTAC
GATAAGCTCATTGTTCGGTTTGGAAGTAGTAAAATTGACAAAGAGCTAATAAACCGAATA
GAGAGAGCCACCGGCCAAAGACCACACCACTTCCTGCGCAGAGGCATCTTCTTCTCACAC
AGAGATATGAATCAGGTTCTTGATGCCTATGAAAATAAGAAGCCATTTTATCTGTACACG
GGCCGGGGCCCCTCTTCTGAAGCAATGCATGTAGGTCACCTCATTCCATTTATTTTCACA
AAGTGGCTCCAGGATGTATTTAACGTGCCCTTGGTGATCCAGATGACGGATGACGAGAAG
TATCTGTGGAAGGACCTGACCCTGGACCAGGCCTATAGCTATGCTGTGGAGAATGCCAAG
GACATCATCGCCTGTGGCTTTGACATCAACAAGACTTTCATATTCTCTGACCTGGACTAC
ATGGGGATGAGCTCAGGTTTCTACAAAAATGTGGTGAAGATTCAAAAGCATGTTACCTTC
AACCAAGTGAAAGGCATTTTCGGCTTCACTGACAGCGACTGCATTGGGAAGATCAGTTTT
CCTGCCATCCAGGCTGCTCCCTCCTTCAGCAACTCATTCCCACAGATCTTCCGAGACAGG
ACGGATATCCAGTGCCTTATCCCATGTGCCATTGACCAGGATCCTTACTTTAGAATGACA
AGGGACGTCGCCCCCAGGATCGGCTATCCTAAACCAGCCCTGTTGCACTCCACCTTCTTC
CCAGCCCTGCAGGGCGCCCAGACCAAAATGAGTGCCAGCGACCCCAACTCCTCCATCTTC
CTCACCGACACGGCCAAGCAGATCAAAACCAAGGTCAATAAGCATGCGTTTTCTGGAGGG
AGAGACACCATCGAGGAGCACAGGCAGTTTGGGGGCAACTGTGATGTGGACGTGTCTTTC
ATGTACCTGACCTTCTTCCTCGAGGACGACGACAAGCTCGAGCAGATCAGGAAGGATTAC
ACCAGCGGAGCCATGCTCACCGGTGAGCTCAAGAAGGCACTCATAGAGGTTCTGCAGCCC
TTGATCGCAGAGCACCAGGCCCGGCGCAAGGAGGTCACGGATGAGATAGTGAAAGAGTTC
ATGACTCCCCGGAAGCTGTCCTTCGACTTTCAGTAG

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
M77804

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_7_Locus:
14q32.31

# Macromolecular_Interacting_Partner_7_SNPs:
rs9453; rs2234529; rs941928; rs8012938; rs8022027; rs2400898; rs2400899; rs941927; rs4905956; rs941929; rs941930; rs941931; rs3994912; rs6575775; rs3783346; rs10149239; rs2301240; rs3783347; rs12888855; rs7150701; rs4905957; rs10149438; rs1887198; rs10438233; rs11622361; rs941923; rs1009812; rs9324020; rs2146106; rs2146107; rs7154151; rs11160582; rs10438234; rs2234532; rs10438232; rs1373; rs10142340; rs4905953; rs2234528; rs4905954; rs1570305; rs1983770; rs4900463; rs7144866; rs10141823; rs732625; rs11624738; rs9671761; rs7156157; rs8009897; rs8009435; rs10141847; rs11620717; rs8010851; rs10873516; rs12882639; rs4905952; rs8008560; rs11626703; rs11624974; rs2234523; rs8009578; rs8009443; rs7155068; rs11626882; rs2234530; rs4905951; rs2234533; rs10142580; rs7154999; rs2234525; rs10141925; rs732626; rs11627197; rs11629422; rs7157522; rs3783345; rs2234524; rs11629457; rs11623879; rs8022658; rs8009765; rs11160581; rs3742384; rs8012062; rs6575773; rs3742383; rs12887559; rs2234520; rs2234521; rs2234522; rs11541753; rs1803791; rs11541754; rs3825556; rs34312584; rs34511223; rs2247044; rs34255137; rs34903259; rs2400915; rs12887392; rs2400906; rs2400916; rs1051002; rs1051043; rs12888583; rs2400905; rs34428908; rs2400904; rs6575774; rs13885; rs3838956; rs2400913; rs1131344; rs35551916; rs33915530; rs8018305; rs2246904; rs2400914; rs7906; rs1131345; rs2400902; rs2400911; rs2400918; rs2400909; rs5810994; rs1051022; rs11271487; rs2478493; rs3809407; rs8021207; rs1051051; rs2400917; rs2400912; rs10612736; rs2400903; rs2478492; rs35916618; rs2246905; rs34107388; rs35100722; rs2400907; rs2400900; rs2400910; rs34966278; rs2400908; rs2400901; rs34345611; rs12887608; rs34304748; rs3783341; rs35102588; rs12896648; rs34231621; rs11279498; rs28633946; rs12882218; rs28651775; rs11626328; rs35384251; rs35863763; rs12880435; rs2234526; rs12892068; rs3842315; rs12880834; rs3783342; rs10636945; rs34070753; rs12896107; rs5810992; rs8004957; rs34657918; rs28708874; rs35136309; rs10593205; rs12888911; rs34115089; rs35387609; rs2234531; rs11383055; rs8020597; rs4520782; rs36210845; rs8004757; rs35594168; rs12880110; rs34489833; rs11160583; rs11624811; rs12882363; rs2281893; rs12880803; rs7142222; rs35725702; rs33934327; rs7141631; rs8020087; rs2400879; rs9707505; rs12880761; rs33939310; rs3783343; rs2234527; rs4900461; rs12892489; rs34040257; rs10148928; rs10619515; rs35202616; rs12881475; rs12887585; rs11276770; rs3783344; rs34113960; rs35520638; rs33952550; rs11394611; rs34924236; rs35032026; rs34256537; rs10144242; rs10147903; rs11160584; rs11622502; rs12882934; rs12897338; rs12897688; rs17554326; rs1951519; rs1957453; rs2146104; rs2146105; rs2181170; rs2234517; rs2234518; rs2234519; rs2273800; rs2273801; rs2273802; rs2273803; rs2273804; rs2475486; rs3117689; rs34007610; rs34184867; rs34205276; rs34277171; rs34331240; rs35007880; rs35097172; rs35966201; rs36056565; rs3736951; rs3736952; rs3742380; rs3742381; rs3742382; rs3742387; rs3764786; rs4905950; rs7143025; rs7147511; rs7155877; rs724392; rs732898; rs8007184; rs8015259; rs9324019; rs941926; rs9972137

# Macromolecular_Interacting_Partner_7_General_References:
1761529; 1763065; 1765274; 1537332; 8724762; 7685728; 1286667; 1373391

# Macromolecular_Interacting_Partner_7_References:
16806831; 16875845; 16876255; 16914686

# Macromolecular_Interacting_Partner_8_ID:
7636

# Macromolecular_Interacting_Partner_8_Name:
Brain-derived neurotrophic factor precursor

# Macromolecular_Interacting_Partner_8_Synonyms:
BDNF; Abrineurin

# Macromolecular_Interacting_Partner_8_Gene_Name:
BDNF

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Brainderived neurotrophic factor precursor
MTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLA
DTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAA
NMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQY
FYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCT
LTIKRGR

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
247

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
27818

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
9.01

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00243:NGF

# Macromolecular_Interacting_Partner_8_Signals:
1-18

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
179403

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
BDNF_HUMAN (P23560)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
BDNF

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
BDNF

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:1033

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>744 bp
ATGACCATCCTTTTCCTTACTATGGTTATTTCATACTTTGGTTGCATGAAGGCTGCCCCC
ATGAAAGAAGCAAACATCCGAGGACAAGGTGGCTTGGCCTACCCAGGTGTGCGGACCCAT
GGGACTCTGGAGAGCGTGAATGGGCCCAAGGCAGGTTCAAGAGGCTTGACATCATTGGCT
GACACTTTCGAACACGTGATAGAAGAGCTGTTGGATGAGGACCAGAAAGTTCGGCCCAAT
GAAGAAAACAATAAGGACGCAGACTTGTACACGTCCAGGGTGATGCTCAGTAGTCAAGTG
CCTTTGGAGCCTCCTCTTCTCTTTCTGCTGGAGGAATACAAAAATTACCTAGATGCTGCA
AACATGTCCATGAGGGTCCGGCGCCACTCTGACCCTGCCCGCCGAGGGGAGCTGAGCGTG
TGTGACAGTATTAGTGAGTGGGTAACGGCGGCAGACAAAAAGACTGCAGTGGACATGTCG
GGCGGGACGGTCACAGTCCTTGAAAAGGTCCCTGTATCAAAAGGCCAACTGAAGCAATAC
TTCTACGAGACCAAGTGCAATCCCATGGGTTACACAAAAGAAGGCTGCAGGGGCATAGAC
AAAAGGCATTGGAACTCCCAGTGCCGAACTACCCAGTCGTACGTGCGGGCCCTTACCATG
GATAGCAAAAAGAGAATTGGCTGGCGATTCATAAGGATAGACACTTCTTGTGTATGTACA
TTGACCATTAAAAGGGGAAGATAG

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
M37762

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_8_Locus:
11p13

# Macromolecular_Interacting_Partner_8_SNPs:
rs11030119; rs1013402; rs6484320; rs7103873; rs7104207; rs2030324; rs7103411; rs2030323; rs16917237; rs2049046; rs10767664; rs7482752; rs7934165; rs988748; rs962369; rs10835211; rs11030121; rs7127507; rs11826087; rs10767665; rs7483223; rs12293082; rs1158615; rs10835214; rs10835215; rs10767662; rs10160339; rs7944119; rs13306221; rs10219241; rs4923468; rs12575096; rs11030117; rs11030116; rs7931214; rs962368; rs10767666; rs11030112; rs36211437; rs4923466; rs6484321; rs12807356; rs36211436; rs12292980; rs11030120; rs7926362; rs2883187; rs7931755; rs12273363; rs36211441; rs28383487; rs4333984; rs1829469; rs34775831; rs12804186; rs10603158; rs4633417; rs982495; rs7937405; rs34640261; rs36186721; rs35882286; rs36211435; rs36154247; rs34000680; rs11500197; rs35365597; rs11428064; rs7930226; rs35038967; rs10626744; rs1949513; rs41282914; rs11030118; rs5790663; rs41282918; rs36137816; rs34782136; rs34097841; rs34006299; rs1967554; rs4505020; rs4378341; rs10835213; rs34137922; rs11375149; rs7942023; rs33973780; rs35952596; rs34379767; rs10767663; rs34590225; rs34710639; rs36080697; rs41282916; rs7126155; rs7943622; rs12790234; rs12099399; rs34043390; rs4542361; rs34845916; rs4385847; rs35397930; rs35092401; rs4258332; rs12801337; rs12790808; rs12289769; rs35935579; rs4922793; rs33943251; rs11607106; rs35791154; rs34321446; rs6484326; rs35699873; rs35168316; rs11030115; rs36162242; rs10835216; rs35920578; rs34006734; rs11030111; rs4390309; rs35641613; rs11030113; rs4923467; rs41274436; rs41274440; rs41274434; rs41274438; rs41274442; rs7929344; rs34194909; rs34578636; rs1048218; rs1048220; rs1048221; rs1048241; rs10501087; rs10767658; rs10767660; rs10767661; rs10835210; rs11030098; rs11030101; rs11030102; rs11030104; rs11030107; rs11030108; rs11030109; rs11030123; rs11819808; rs11825814; rs11826739; rs12273539; rs12284158; rs12284724; rs12288512; rs12291063; rs12291186; rs12419948; rs12790077; rs1401635; rs1491850; rs1491851; rs1519479; rs1519480; rs16917204; rs16917234; rs16917271; rs16917274; rs17309874; rs17309930; rs2049045; rs2049047; rs2049048; rs2203877; rs2353512; rs3178739; rs3750934; rs4923463; rs6265; rs7102921; rs7124442; rs727155; rs7931247; rs7940188; rs8192466; rs908867; rs925946; rs925947; rs925948

# Macromolecular_Interacting_Partner_8_General_References:
2236018; 1889806; 1339267; 2025430; 8527932; 11214319; 7703225; 11152678; 10391209; 14566559

# Macromolecular_Interacting_Partner_8_References:
17029253; 17074039

# Macromolecular_Interacting_Partner_9_ID:
7644

# Macromolecular_Interacting_Partner_9_Name:
14-3-3 protein theta

# Macromolecular_Interacting_Partner_9_Synonyms:
14-3-3 protein tau; 14-3-3 protein T-cell; HS1 protein

# Macromolecular_Interacting_Partner_9_Gene_Name:
YWHAQ

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>1433 protein theta
MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWR
VISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLK
MKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYE
ILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAA
EGAEN

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
245

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
27764

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
4.41

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  protein domain specific binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00244:14-3-3

# Macromolecular_Interacting_Partner_9_Signals:
None

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
23222

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
1433T_HUMAN (P27348)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
YWHAQ

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
YWHAQ

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:12854

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Cytoplasm. Note=In neurons, axonally transported to the nerve terminals

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>738 bp
ATGGAGAAGACTGAGCTGATCCAGAAGGCCAAGCTGGCCGAGCAGGCCGAGCGCTACGAC
GACATGGCCACCTGCATGAAGGCAGTGACCGAGCAGGGCGCCGAGCTGTCCAACGAGGAG
CGCAACCTGCTCTCCGTGGCCTACAAGAACGTGGTCGGGGGCCGCAGGTCCGCCTGGAGG
GTCATCTCTAGCATCGAGCAGAAGACCGACACCTCCGACAAGAAGTTGCAGCTGATTAAG
GACTATCGGGAGAAAGTGGAGTCCGAGCTGAGATCCATCTGCACCACGGTGCTGGAATTG
TTGGATAAATATTTAATAGCCAATGCAACTAATCCAGAGAGTAAGGTCTTCTATCTGAAA
ATGAAGGGTGATTACTTCCGGTACCTTGCTGAAGTTGCGTGTGGTGATGATCGAAAACAA
ACGATAGATAATTCCCAAGGAGCTTACCAAGAGGCATTTGATATAAGCAAGAAAGAGATG
CAACCCACACACCCAATCCGCCTGGGGCTTGCTCTTAACTTTTCTGTATTTTACTATGAG
ATTCTTAATAACCCAGAGCTTGCCTGCACGCTGGCTAAAACGGCTTTTGATGAGGCCATT
GCTGAACTTGATACACTGAATGAAGACTCATACAAAGACAGCACCCTCATCATGCAGTTG
CTTAGAGACAACCTAACACTTTGGACATCAGACAGTGCAGGAGAAGAATGTGATGCGGCA
GAAGGGGCTGAAAACTAA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
X56468

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_9_Locus:
2p25.1

# Macromolecular_Interacting_Partner_9_SNPs:
rs16822436; rs11676903; rs6432023; rs7608161; rs11674777; rs6432025; rs11674769; rs11890807; rs3791748; rs12692388; rs11888451; rs4668625; rs1111976; rs11684568; rs10495572; rs16867083; rs1524667; rs17362839; rs7601942; rs11681780; rs16867065; rs2357157; rs13415136; rs11674917; rs13388486; rs6432020; rs13417081; rs11902264; rs4669401; rs10520030; rs10495571; rs6432024; rs10495570; rs13024360; rs13025344; rs16867082; rs6734469; rs7597961; rs17362902; rs7569485; rs17453752; rs6748558; rs17362853; rs16867063; rs3951115; rs11689741; rs6745213; rs11892623; rs17362734; rs10210225; rs16867073; rs16867064; rs12476008; rs4429446; rs4669400; rs13420746; rs11693980; rs16867074; rs17453675; rs10929591; rs7556678; rs11695334; rs7565646; rs7567811; rs6720625; rs16867075; rs11887863; rs16867066; rs7558086; rs16867078; rs11902431; rs17453724; rs13415111; rs6706227; rs13022460; rs16867084; rs7556890; rs2091210; rs10203320; rs11692112; rs17428551; rs11544465; rs11544462; rs1130874; rs11544459; rs11544463; rs11544466; rs6758214; rs41264177; rs6754543; rs6754559; rs11544464; rs7594; rs35056773; rs7596076; rs34108301; rs7605763; rs35321100; rs1630042; rs11900061; rs2510846; rs1790036; rs34963513; rs1620756; rs28665417; rs34902007; rs6705840; rs6715408; rs1969436; rs16867080; rs34872137; rs11888902; rs35323595; rs13433069; rs34048944; rs12999819; rs13017323; rs34640890; rs9750287; rs1969439; rs13013116; rs34331149; rs34085406; rs2510844; rs34794356; rs12994716; rs35089410; rs28368421; rs41308184; rs10202035; rs35581018; rs34658147; rs10170653; rs1969440; rs28439627; rs13020163; rs35000301; rs1534044; rs13401147; rs12478274; rs1969438; rs3951116; rs12994731; rs35332379; rs10177405; rs13002246; rs36088984; rs13024142; rs2510845; rs13007969; rs6432021; rs35425869; rs36039023; rs13029449; rs3018094; rs34127051; rs11678569; rs7562098; rs1969437; rs13398449; rs35874826; rs34038792; rs35428813; rs33920918; rs3834784; rs34371100; rs35939717; rs7597050; rs35677663; rs34701516; rs10187701; rs10193583; rs10197336; rs10427360; rs10929590; rs1534043; rs16867062; rs1722694; rs1722696; rs1722697; rs1790037; rs1790038; rs1790039; rs1790040; rs35458571; rs3762535; rs4145375; rs4668626; rs4669402; rs6432018; rs6715748; rs6749616; rs6752971; rs7556757; rs7564270; rs7589625

# Macromolecular_Interacting_Partner_9_General_References:
2015305; 8515476; 12665801; 7603573

# Macromolecular_Interacting_Partner_9_References:
17080964

# Macromolecular_Interacting_Partner_10_ID:
5481

# Macromolecular_Interacting_Partner_10_Name:
Succinate semialdehyde dehydrogenase, mitochondrial precursor

# Macromolecular_Interacting_Partner_10_Synonyms:
NAD(+-dependent succinic semialdehyde dehydrogenase

# Macromolecular_Interacting_Partner_10_Gene_Name:
ALDH5A1

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Succinate semialdehyde dehydrogenase, mitochondrial precursor
MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR
TDSFVGGRWL
PAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKE
RSSLLRKWYNLMIQNKDDLAR
IITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDI
IHTPAKDRRALVLKQPIGVAAVITPWNFPSAM
ITRKVGAALAAGCTVVVKPAEDTPFSA
LALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKI
SFTGSTTTGKILLHHA
ANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQR
GIHDA
FVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQL
GKNFF
EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQD
PAQIWRVAEQLEVGMV
GVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYG
GL

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
535

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
57215

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
8.37

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Function:  aldehyde dehydrogenase activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_10_General_Function:
Energy production and conversion 

# Macromolecular_Interacting_Partner_10_Specific_Function:
Succinate semialdehyde + NAD(+) + H(2)O = succinate + NADH

# Macromolecular_Interacting_Partner_10_Pathway:
map00251  Glutamate metabolism;
 map00650  Butanoate metabolism

# Macromolecular_Interacting_Partner_10_Reaction:
succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00171:Aldedh

# Macromolecular_Interacting_Partner_10_Signals:
None

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
EC 1.2.1.24

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
3766467

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
SSDH_HUMAN (P51649)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
ALDH5A1

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
ALDH5A1

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:408

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>1608 bp

ATGGCGACCTGCATTTGGCTGCGGAGCTGTGGGGCCCGGCGCCTCGGGTCGACGTTTCC
AGGCTGCCGCC
TCCGCCCCCGCGCCGGCGGCCTGGTCCCTGCCTCCGGGCCTGCGCCCG
GCCCGGCCCAGCTCCGCTGCTA
CGCTGGGCGCCTGGCGGGCCTCTCTGCGGCGCTGCTG
CGCACCGACAGCTTCGTGGGCGGCCGCTGGCTC
CCGGCCGCCGCCACCTTCCCCGTGCA
AGACCCGGCCAGCGGCGCCGCTCTGGGCATGGTAGCCGACTGCG
GGGTGCGAGAGGCCC
GCGCCGCCGTGCGCGCTGCCTACGAGGCTTTCTGCCGCTGGAGGGAGGTCTCCGC
CAAG
GAGAGGAGTTCATTACTTCGGAAGTGGTACAATTTAATGATACAAAATAAGGATGACCTT
GCCAGA
ATAATCACAGCTGAAAGTGGAAAGCCACTGAAGGAGGCACATGGAGAAATTCT
CTATTCCGCCTTTTTCC
TAGAGTGGTTCTCTGAGGAAGCCCGCCGTGTTTACGGAGACA
TTATCCACACCCCGGCAAAGGACAGGCG
GGCCCTGGTCCTCAAGCAGCCCATAGGCGTG
GCTGCAGTCATCACCCCGTGGAATTTCCCCAGTGCCATG
ATCACCCGGAAGGTGGGGGC
CGCCCTGGCAGCCGGCTGTACTGTCGTGGTGAAGCCTGCCGAAGACACGC
CCTTCTCCG
CCCTGGCCCTGGCTGAGCTTGCAAGCCAGGCTGGGATTCCTTCAGGTGTATACAATGTTA
T
TCCCTGTTCTCGAAAGAATGCCAAGGAAGTAGGGGAGGCAATTTGTACTGATCCTCTG
GTGTCCAAAATT
TCCTTTACTGGTTCAACAACTACAGGAAAGATCCTGTTGCACCACGC
AGCAAACTCTGTGAAAAGGGTCT
CTATGGAGCTGGGCGGCCTTGCTCCATTTATAGTAT
TTGACAGTGCCAACGTGGACCAGGCTGTAGCAGG
GGCCATGGCATCTAAATTTAGGAAC
ACTGGACAGACTTGTGTTTGCTCAAACCAATTCTTGGTGCAAAGG
GGCATCCATGATGC
CTTTGTAAAAGCATTCGCCGAGGCCATGAAGAAGAACCTGCGCGTAGGTAATGGAT
TTG
AGGAAGGAACTACTCAGGGCCCATTAATTAATGAAAAAGCGGTAGAAAAGGTGGAGAAAC
AGGTGAA
TGATGCCGTTTCTAAAGGTGCCACCGTTGTGACAGGTGGAAAACGACACCAA
CTTGGAAAAAATTTCTTT
GAGCCTACCCTGCTGTGCAATGTCACCCAGGACATGCTGTG
CACTCATGAAGAGACTTTCGGGCCTCTGG
CACCAGTTATCAAGTTCGATACAGAGGAGG
AGGCTATAGCAATCGCTAACGCAGCTGATGTTGGGTTAGC
AGGTTATTTTTACTCTCAA
GACCCAGCCCAGATCTGGAGAGTGGCAGAGCAGCTGGAAGTGGGCATGGTT
GGCGTCAA
CGAAGGATTAATTTCCTCTGTGGAGTGCCCTTTTGGTGGAGTGAAGCAGTCCGGCCTTGG
GC
GAGAGGGGTCCAAGTATGGCATTGATGAGTATCTGGAACTCAAGTATGTGTGTTACG
GGGGCTTGTAG

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
Y11192

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_10_Locus:
6p22.2-p22.3

# Macromolecular_Interacting_Partner_10_SNPs:
Not Available

# Macromolecular_Interacting_Partner_10_General_References:
9683595; 14574404; 7814412; 9059628

# Macromolecular_Interacting_Partner_10_References:
16483879; 16504488; 16601881

# Macromolecular_Interacting_Partner_11_ID:
7120

# Macromolecular_Interacting_Partner_11_Name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit precursor

# Macromolecular_Interacting_Partner_11_Synonyms:
G gamma-I

# Macromolecular_Interacting_Partner_11_Gene_Name:
GNG2

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Guanine nucleotidebinding protein GI/GS/GO gamma2 subunit precursor
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
FREKKFFCAIL

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
71

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
7850

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
8.22

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  signal transducer activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  extrinsic to membrane
Component:  extrinsic to plasma membrane
Component:  heterotrimeric G-protein complex

# Macromolecular_Interacting_Partner_11_General_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Specific_Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF00631:G-gamma

# Macromolecular_Interacting_Partner_11_Signals:
None

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
20147633

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
GBG2_HUMAN (P59768)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
GNG2

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
GNG2

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:4404

# Macromolecular_Interacting_Partner_11_PDB_ID:
1GP2

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Cell membrane; lipid-anchor; cytoplasmic side (Potential)

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>216 bp
ATGGCCAGCAACAACACCGCCAGCATAGCACAAGCCAGGAAGCTGGTAGAGCAGCTTAAG
ATGGAAGCCAATATCGACAGGATAAAGGTGTCCAAGGCAGCTGCAGATTTGATGGCCTAC
TGTGAAGCACATGCCAAGGAAGACCCCCTCCTGACCCCTGTTCCGGCTTCAGAAAACCCG
TTTAGGGAGAAGAAGTTTTTCTGTGCCATCCTTTAA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
AF493870

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_11_Locus:
14q21

# Macromolecular_Interacting_Partner_11_SNPs:
rs2173147; rs1540703; rs1057804; rs1890698; rs1953861; rs1253671; rs1253705; rs10150753; rs4898723; rs8008081; rs4271524; rs8014746; rs8017436; rs2357306; rs1618825; rs8006278; rs1959517; rs4271525; rs1253685; rs8019194; rs1253687; rs1693198; rs1253707; rs3204006; rs6572805; rs1253669; rs8014732; rs7153584; rs12883315; rs6572803; rs4901174; rs1253696; rs12883290; rs7158342; rs8019331; rs11157869; rs12435475; rs10131301; rs12889199; rs4898725; rs1253690; rs7154422; rs6572804; rs8011452; rs1253703; rs12435509; rs2000006; rs4901173; rs6572802; rs1253691; rs11621156; rs11851703; rs7160163; rs7154419; rs11157865; rs11623465; rs1253708; rs1253672; rs10143072; rs8020243; rs10498440; rs8015777; rs11623590; rs1253692; rs11157864; rs11623924; rs7152919; rs11624752; rs17124753; rs11625611; rs1959518; rs2357302; rs12434038; rs12894908; rs12882906; rs1874566; rs8019382; rs3742539; rs11621160; rs8007155; rs10498438; rs1343870; rs10498439; rs8010684; rs1953859; rs1253686; rs12147761; rs1890699; rs10129965; rs11157866; rs2357249; rs4901171; rs1623101; rs11624779; rs8009095; rs12588848; rs1693203; rs1253698; rs4514593; rs10133203; rs1253704; rs3742541; rs2275459; rs8009132; rs11622145; rs1253706; rs10146408; rs7143686; rs2357247; rs1253699; rs7150643; rs8010820; rs10147806; rs17124732; rs1253689; rs1253700; rs2357304; rs1269967; rs9635225; rs17124751; rs1953858; rs7148779; rs35277565; rs12588519; rs11625461; rs8003709; rs8009835; rs10147177; rs4901175; rs1253693; rs11628249; rs8009405; rs10144829; rs1693199; rs12880965; rs2357305; rs8014838; rs8005440; rs7143789; rs12890422; rs12100449; rs3818870; rs1316298; rs7494751; rs1578974; rs17124744; rs11621108; rs3742540; rs7144109; rs1253702; rs17252733; rs17124725; rs17124746; rs3742537; rs1109745; rs12101277; rs1253701; rs11850819; rs8010780; rs10220546; rs17124713; rs12895034; rs17124709; rs7153274; rs3204008; rs11847330; rs1253632; rs1262155; rs17092983; rs3825596; rs7143009; rs1253656; rs1693204; rs1253636; rs1253634; rs4898728; rs1032583; rs1032582; rs1253657; rs7141670; rs3825604; rs10873055; rs8019374; rs7147405; rs1253660; rs4633613; rs1253655; rs1253645; rs3825603; rs3825597; rs12431532; rs1253646; rs1253633; rs3825602; rs2236561; rs1253642; rs1032584; rs1253643; rs1253648; rs1253658; rs1253644; rs17124780; rs12432144; rs1253647; rs12436573; rs1271518; rs1253664; rs12433722; rs1253652; rs17124772; rs3825600; rs17124796; rs4898727; rs1253639; rs1497089; rs12431528; rs11850096; rs1253662; rs1253665; rs12433696; rs1253640; rs12894196; rs1272117; rs1253649; rs11847688; rs1253638; rs17124774; rs1253641; rs3825601; rs1693177; rs1253635; rs2236562; rs17124768; rs11157867; rs1253653; rs8019625; rs1253654; rs7144097; rs1253663; rs11847372; rs7159454; rs11157868; rs1253650; rs17831501; rs1253666; rs1253651; rs17124698; rs9743514; rs950010; rs12889322; rs36047102; rs36067357; rs35614601; rs4523850; rs35174771; rs35178030; rs35139612; rs12889284; rs7148451; rs35822692; rs12886703; rs35819066; rs35462757; rs10539775; rs35213821; rs35673554; rs17831464; rs8011560; rs17124735; rs35190987; rs34192983; rs2884152; rs35975919; rs28694719; rs1497081; rs36016212; rs10717240; rs34445110; rs11354444; rs35455303; rs36032151; rs7158119; rs4898724; rs34308582; rs34283228; rs5808640; rs8011272; rs34329964; rs35145745; rs34857364; rs1693193; rs12890418; rs34693198; rs12586590; rs10689259; rs35336316; rs11322637; rs11322270; rs34146466; rs35195529; rs35803539; rs4347544; rs2067829; rs11428089; rs1953860; rs17252712; rs5808641; rs34973942; rs11315945; rs34499635; rs33911162; rs35429944; rs35289455; rs7161446; rs28718093; rs8013372; rs1253688; rs2357303; rs34764790; rs7156066; rs10543520; rs34028168; rs11623464; rs1253694; rs10150861; rs34653407; rs35238426; rs35433627; rs35848969; rs1959516; rs12586607; rs35870554; rs28459525; rs35495615; rs10083534; rs10539774; rs35583464; rs35727674; rs35105434; rs12882099; rs33955770; rs12895248; rs11463019; rs1272118; rs1253695; rs34361665; rs1253697; rs12894239; rs8005542; rs34031930; rs35437257; rs35846208; rs35134680; rs36078788; rs34449528; rs28410474; rs12896633; rs35857266; rs35561589; rs35748925; rs34420705; rs3030340; rs35420086; rs12589934; rs35009719; rs36010201; rs34591914; rs1959519; rs34670484; rs11288986; rs34986921; rs35088349; rs12894231; rs35622909; rs34263394; rs34779533; rs4456417; rs8010602; rs10624821; rs34877164; rs33974701; rs4901172; rs34780909; rs34248762; rs4309306; rs34782634; rs5808639; rs8004034; rs35616481; rs5808645; rs34701338; rs34410329; rs17124728; rs34480788; rs35453948; rs12889304; rs9707478; rs35484737; rs10604942; rs35494600; rs3832939; rs36123684; rs35923674; rs35156219; rs4898726; rs35052096; rs35374258; rs34240079; rs34350221; rs28688492; rs35192783; rs35005802; rs34991244; rs34006183; rs10134518; rs10140188; rs2357248; rs1253673; rs5808642; rs2047364; rs34966733; rs1620540; rs34110528; rs17124723; rs33933786; rs6145342; rs33922275; rs34470726; rs5808643; rs2790507; rs35561836; rs35675957; rs1769485; rs34653524; rs35548218; rs1693171; rs4589468; rs35319859; rs35289575; rs1269018; rs11326387; rs11301975; rs1769484; rs34265134; rs10646775; rs10636640; rs11301974; rs1253637; rs1693172; rs10684028; rs1693202; rs28437731; rs11847369; rs3825598; rs28613476; rs10643481; rs34424623; rs34270098; rs5808644; rs17252747; rs1253659; rs35702479; rs33913949; rs35088804; rs1253661; rs35348536; rs1769486; rs34736340; rs11847426; rs17831409; rs35153814; rs10529707; rs10137625; rs10138800; rs10145910; rs10146660; rs10150721; rs10151155; rs11844663; rs11844741; rs12433790; rs12436400; rs12436887; rs12587228; rs12589956; rs12878101; rs12878420; rs12886319; rs1693194; rs1693195; rs17124691; rs17124692; rs17124695; rs17124696; rs17124815; rs17252644; rs1769483; rs2357245; rs2357246; rs34468044; rs34867128; rs4901170; rs7154813

# Macromolecular_Interacting_Partner_11_General_References:
10833460

# Macromolecular_Interacting_Partner_11_References:
16903850; 16966477

# Macromolecular_Interacting_Partner_12_ID:
6979

# Macromolecular_Interacting_Partner_12_Name:
Somatostatin precursor

# Macromolecular_Interacting_Partner_12_Synonyms:
Growth hormone release-inhibiting factor[Contains: Somatostatin-28; Somatostatin-14]

# Macromolecular_Interacting_Partner_12_Gene_Name:
SST

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Somatostatin precursor
MLSCRLQCALAALSIVLALGCVTGAPSDPRLRQFLQKSLAAAAGKQELAKYFLAELLSEP
NQTENDALEPEDLSQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
116

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
12736

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
5.18

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
Somatostatin inhibits the release of somatotropin

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF03002:Somatostatin

# Macromolecular_Interacting_Partner_12_Signals:
1-24

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
338288

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
SMS_HUMAN (P61278)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
SST

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
SST

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:11329

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>351 bp
ATGCTGTCCTGCCGCCTCCAGTGCGCGCTGGCTGCGCTGTCCATCGTCCTGGCCCTGGGC
TGTGTCACCGGCGCTCCCTCGGACCCCAGACTCCGTCAGTTTCTGCAGAAGTCCCTGGCT
GCTGCCGCGGGGAAGCAGGAACTGGCCAAGTACTTCTTGGCAGAGCTGCTGTCTGAACCC
AACCAGACGGAGAATGATGCCCTGGAACCTGAAGATCTGTCCCAGGCTGCTGAGCAGGAT
GAAATGAGGCTTGAGCTGCAGAGATCTGCTAACTCAAACCCGGCTATGGCACCCCGAGAA
CGCAAAGCTGGCTGCAAGAATTTCTTCTGGAAGACTTTCACATCCTGTTAG

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
J00306

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_12_Locus:
3q28

# Macromolecular_Interacting_Partner_12_SNPs:
rs33934967; rs35603672; rs4988514; rs4988513; rs34477564; rs7624906; rs6797699; rs17796004; rs10513818; rs10513817; rs3755792; rs9822131; rs6784777; rs35435818; rs34907490; rs34148761; rs35648422; rs34026617; rs6784778; rs34714141; rs35517186; rs11544862; rs10576690; rs17796022; rs34988133; rs4988512; rs10704560; rs35410638; rs34872250; rs34488209; rs35880616; rs35564993; rs35405263; rs3834203; rs35293276; rs36047944; rs10513819; rs12495024; rs12635290; rs12636935; rs12638067; rs13434247; rs1365111; rs1365112; rs1365113; rs1425922; rs1425923; rs16862441; rs16862444; rs17728902; rs2114118; rs2114119; rs2162188; rs2162189; rs3864101; rs6786957; rs6789745; rs6794112; rs7626009; rs7631984; rs9290858; rs9810336; rs9842256; rs9842351; rs9842483; rs9852989; rs9865318; rs9872531

# Macromolecular_Interacting_Partner_12_General_References:
6126875; 6142531

# Macromolecular_Interacting_Partner_12_References:
16413119

# Macromolecular_Interacting_Partner_13_ID:
5480

# Macromolecular_Interacting_Partner_13_Name:
4-aminobutyrate aminotransferase, mitochondrial precursor

# Macromolecular_Interacting_Partner_13_Synonyms:
(S-3-amino-2-methylpropionate transaminase; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA aminotransferase; GABA-AT; GABA-T; L-AIBAT

# Macromolecular_Interacting_Partner_13_Gene_Name:
ABAT

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>4aminobutyrate aminotransferase, mitochondrial precursor
MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMK
QLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQ
NASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYR
SKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPS
FDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGG
DNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMM
TGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLL
DLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVF
RDHHAHLFLNIFSDILADFK

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
500

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
56440

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
8.04

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
Function:  4-aminobutyrate transaminase activity
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid derivative metabolism
Process:  gamma-aminobutyric acid metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_13_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_13_Specific_Function:
Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine

# Macromolecular_Interacting_Partner_13_Pathway:
map00280  Valine, leucine and isoleucine degradation;
GENES       ECO: b2662(gabT);
            ECJ: JW2637(gabT);
            ECE: Z3960(gabT);
            ECS: ECs3523;
            ECC: c3210(gabT);
            STY: STY2912(gabT);
            STT: t2687(gabT);
            SPT: SPA2649(gabT);
            SEC: SC2724(gabT);
            STM: STM2792(gabT);
            YPE: YPO2844(goaG);
            YPK: y1390(goaG);
            YPM: YP2711(goaG);
            YPS: YPTB2810(goaG);
            SFL: SF2689(gabT);
            SFX: S2874(gabT);
            ECA: ECA2053(gabT);
            PLU: plu2347(goaG);
            VPA: VP1771;
            PAE: PA0266(gabT);
            PPU: PP0214(gabT);
            PST: PSPTO0301(gabT-2);
            PSB: Psyr_0090;
            ACI: ACIAD3446(gabT);
            SON: SO1276(gabT);
            CVI: CV3926(goaG);
            RSO: RSc0029(goaG);
            BMA: BMAA1480(gabT);
            BPS: BPSS0281(gabT);
            BPE: BP2298;
            BPA: BPP2431;
            BBR: BB1880;
            MLO: mlr5521;
            SME: SMb21186(gabT);
            RPA: RPA2323(goaT);
            SIL: SPOA0274(gabT);
            BAN: BA0325(gabT);
            BAR: GBAA0325(gabT);
            BAA: BA_0895;
            BAT: BAS0310;
            BCA: BCE0354(gabT);
            BCZ: BCZK0297(gabT)

# Macromolecular_Interacting_Partner_13_Reaction:
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF00202:Aminotran_3

# Macromolecular_Interacting_Partner_13_Signals:
None

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
EC 2.6.1.19;EC 2.6.1.22

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
602705

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
GABT_HUMAN (P80404)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
ABAT

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
ABAT

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:23

# Macromolecular_Interacting_Partner_13_PDB_ID:
1OHY

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>1503 bp
ATGGCCTCCATGTTGCTCGCCCAGCGGCTGGCCTGCAGCTTCCAGCACACGTACCGCCTG
CTGGTGCCTGGATCCAGACACATTAGTCAAGCTGCAGCCAAAGTCGACGTTGAATTTGAT
TATGATGGGCCTCTGATGAAGACGGAAGTCCCAGGGCCTAGATCTCAGGAGTTAATGAAA
CAGCTGAATATAATTCAGAATGCAGAGGCTGTGCATTTTTTCTGCAATTACGAAGAGAGC
CGAGGCAATTACCTGGTTGATGTGGACGGCAACCGAATGCTGGATCTTTATTCCCAGATC
TCCTCTGTTCCCATAGGTTACAGCGACCCGGCCCTCGTGAAACTCATCCAACAGCCACAA
AATGCGAGCATGTTTGTCAACAGACCCGCCCTCGAAATCCTGCCTCCGGAGAACTTTGTG
GAGAAGCTCCGGCAGTCCTTGCTCTCGGTGGCTCCCAAAGGGATGTCCCAGCTCATCACC
ATGGCCTGCGGCTCCTGCTCCAATGAAAACGCCTTAAAGACCATCTTCATGTGGTACCGG
AGCAAGGAAAGAGGGCAGAGGGGATTCTCCAAAGAGGAGCTGGAGACGTGCATGATTAAC
CAGGCCCCCTGGTGCCCCGACTACAGCATCCTCTCCTTCATGGGTTCCTTCCATGGGAGG
ACCATGGGTTGCTTAGCGACCACGCACTCTAAAGCCATTCACAAGATCGATATCCCTTCC
TTTGACTGGCCCATCGCACCGTTCCCACGGCTGAAATACCCTCTGGAAGAGTTTGTGAAA
GAGAACCAACAGGAAGAGGCCGGCTGTCTGGAAGAGGTTGAGGATCTGATTGTGAAATAT
CGAAAAAAGAAGAAGACGGTGGCCGGGATCATCGTGGAGCCCATCCAGTCCGAGGGTGGA
GACAACCATGCATCCGATGACTTCTTTCGGAAGCTGAGAGACATCGCCAGGAAGCACTGC
TGCGCCTTCTTGGTGGACGAGGTCCAGACCGGAGGAGGCTGCACGGGCAAGTTCTGGGCC
CATGAGCACTGGGGCCTGGATGACCCAGCAGACGTGATGACCTTCAGCAAGAAGATGATG
ACTGGGGGCTTCTTCCTCAAGGAGGAGTTCAGGCCTAATGCTCCCTACCGGATCTTCAAC
ACGTGGCTGGGGGACCCGTCCAAGAACCTGTTGCTGGCTGAGGTCATCAACATCATCAAG
CGGGAGGACCTGCTAAATAATGCAGCCCATGCCGGGAAGGCCCTGCTCACAGGACTGCTG
GACCTCCAGGCCCGGTACCCCCAGTTCATCAGCAGGGTGAGAGGACGAGGCACCTTTTGC
TCCTTCGATACTCCCGATGATTCCATACGGAATAAGCTCATTTTAATTGCCAGAAACAAA
GGTGTGGTGTTGGGTGGCTGTGGTGACAAATCCATTCGTTTCCGTCCCACGCTGGTGTTC
AGGGATCACCACGCTCACCTGTTCCTCAATATTTTCAGTGACATCTTAGCAGACTTCAAG
TAA

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
L32961

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_13_Locus:
16p13.2

# Macromolecular_Interacting_Partner_13_SNPs:
rs1731017; rs1641022; rs28687443; rs1731062; rs1006636; rs747329; rs1730951; rs1273350; rs1273394; rs1730948; rs4454975; rs3743801; rs1730946; rs6497519; rs1730941; rs2313427; rs1641113; rs1273364; rs4984996; rs1641107; rs747330; rs1273396; rs11075408; rs6497548; rs1730945; rs6497583; rs1295741; rs1641112; rs1273373; rs1640989; rs1273357; rs4985113; rs8062395; rs1730952; rs7205816; rs1641032; rs3108684; rs1730954; rs1273393; rs7199025; rs4985114; rs4985036; rs1730958; rs9935902; rs1641110; rs6497327; rs4985000; rs1273351; rs8055836; rs1641108; rs1344476; rs1730938; rs1730953; rs1730943; rs1641111; rs1730937; rs4984997; rs17566580; rs737695; rs3095512; rs1289964; rs1273360; rs1273397; rs9456; rs1273381; rs1273359; rs1731071; rs1273353; rs1640997; rs3743798; rs1273355; rs9935408; rs6498753; rs17674530; rs1273356; rs12933164; rs1273376; rs1730956; rs1273361; rs1273390; rs12447371; rs12596289; rs1731083; rs1641031; rs12445987; rs12597124; rs4445904; rs11648372; rs1640995; rs1730961; rs1273395; rs11645254; rs9935422; rs1295740; rs11647162; rs4984998; rs11646372; rs1273366; rs1640979; rs7499026; rs2313548; rs6498755; rs1640980; rs3095514; rs1273372; rs1273363; rs6497565; rs11074405; rs1273358; rs1731061; rs1273382; rs1730955; rs1273352; rs1273367; rs7499025; rs1640971; rs7201586; rs1730949; rs1640974; rs1641106; rs8052707; rs1612155; rs1273391; rs12596654; rs12448579; rs1641109; rs1807439; rs8056063; rs1273349; rs1731081; rs1731082; rs9923953; rs8059639; rs3095516; rs1730944; rs11642785; rs8061555; rs1061842; rs1641105; rs8056550; rs12149040; rs1731078; rs7194430; rs1730959; rs1420082; rs12448693; rs12597484; rs737696; rs1273380; rs1273370; rs8058062; rs1640973; rs1731069; rs1730947; rs1731085; rs1731079; rs2270289; rs3095515; rs1640978; rs1640981; rs1730962; rs1640996; rs9939980; rs1123891; rs8054014; rs1273369; rs1730957; rs9928478; rs8046210; rs12921061; rs2270288; rs7501036; rs11648678; rs1273383; rs1273362; rs11643667; rs1730939; rs1881828; rs1640988; rs2313596; rs12444390; rs1731080; rs17651562; rs16964282; rs9935013; rs7193087; rs11866675; rs8275; rs10261; rs12445958; rs1731070; rs737694; rs8048045; rs7192026; rs7197787; rs8050233; rs1640994; rs3095513; rs8049263; rs12447028; rs11643578; rs3095510; rs1641021; rs9674265; rs8057362; rs1273427; rs1641024; rs1273398; rs1273422; rs1273424; rs2091634; rs7196462; rs1273430; rs1640998; rs8053509; rs8049072; rs9673595; rs12708689; rs4985035; rs1641003; rs1641019; rs6497960; rs7197673; rs1273425; rs12447235; rs1273429; rs8055880; rs1641025; rs1273433; rs3815507; rs1079350; rs4482281; rs11863437; rs1273423; rs1731039; rs1731019; rs1640999; rs1641007; rs12446980; rs12925086; rs13337024; rs13336159; rs9937726; rs933481; rs1273431; rs1641014; rs12446169; rs8060255; rs1641002; rs1078509; rs1273417; rs1641027; rs1641016; rs1731027; rs12448959; rs6497959; rs1273428; rs1079348; rs11862060; rs11074631; rs2103340; rs753071; rs1731026; rs1731072; rs1299926; rs1273420; rs8055737; rs12448823; rs1079349; rs1731086; rs7203297; rs1273406; rs3815508; rs1641001; rs8061093; rs9937937; rs9302405; rs11640989; rs8056083; rs11866199; rs1273426; rs9924807; rs1273419; rs1273402; rs1641030; rs7206830; rs1273421; rs8053030; rs12596790; rs8046201; rs11865147; rs1731087; rs1731073; rs13338443; rs1273415; rs12918897; rs1641010; rs8055927; rs11074534; rs13335330; rs1731030; rs1641015; rs9929124; rs10775278; rs1641023; rs1420084; rs9673228; rs7193333; rs1990574; rs1894861; rs1965648; rs1078511; rs1731020; rs1641008; rs1731034; rs1273407; rs1612383; rs11647952; rs2464048; rs1731018; rs9673371; rs7193305; rs1641011; rs1273416; rs1273400; rs11074713; rs1641029; rs9673409; rs1465319; rs1965649; rs1420085; rs10775279; rs11860865; rs12445730; rs11641035; rs1273408; rs7200886; rs1630164; rs13332999; rs1731029; rs1273401; rs1616856; rs1273412; rs1273418; rs12445609; rs11074695; rs8057162; rs13336186; rs11074533; rs1075853; rs1273413; rs11074712; rs3217123; rs9673401; rs1641026; rs12922831; rs12445687; rs13332215; rs12102631; rs12598074; rs12444233; rs1731036; rs1641006; rs12930556; rs12325344; rs933482; rs13339338; rs1613314; rs1965647; rs8061716; rs4989413; rs2302608; rs1641013; rs8048375; rs1617601; rs12448478; rs1273410; rs1465318; rs8060512; rs1641017; rs12149331; rs13331042; rs8047293; rs4984999; rs11646271; rs10852271; rs9925620; rs10775277; rs8060323; rs9931017; rs1420083; rs7203550; rs1641104; rs1139523; rs1139520; rs35780038; rs41311264; rs1139522; rs1062593; rs1139525; rs34813662; rs1042495; rs1139521; rs1139519; rs8059762; rs35850996; rs1273386; rs1640972; rs34187437; rs12597184; rs28415910; rs7195521; rs36138946; rs28587720; rs1640985; rs12149146; rs1731059; rs34441266; rs28403171; rs9939846; rs1640993; rs1273377; rs34595424; rs35454761; rs1273378; rs7195079; rs35916063; rs1640987; rs1273371; rs9928667; rs4296259; rs13334372; rs28382303; rs35255805; rs33951087; rs1630895; rs1731084; rs1273388; rs16964376; rs34014796; rs35351214; rs1730950; rs7184890; rs34724138; rs1640977; rs4442807; rs1731064; rs17651173; rs7204053; rs1273374; rs1730960; rs2178371; rs1640975; rs3095511; rs2160182; rs13337410; rs35163930; rs28692588; rs8056066; rs34165726; rs1731075; rs35012807; rs35638621; rs1640986; rs5815494; rs28602865; rs1273368; rs1640992; rs28622536; rs1731058; rs12149145; rs7190843; rs28714127; rs35832558; rs8056594; rs1986108; rs33928355; rs1640984; rs34006471; rs8060892; rs28742255; rs9746220; rs12926736; rs35163795; rs1273365; rs34531177; rs3065947; rs1640991; rs34595884; rs34089650; rs35176944; rs34736230; rs2313428; rs10163233; rs1731057; rs8049522; rs730750; rs34452392; rs9941133; rs34403235; rs34698480; rs1640970; rs34686381; rs8056020; rs7196194; rs35069718; rs28581915; rs28589960; rs8046394; rs34733640; rs1640983; rs12446703; rs13337518; rs28609006; rs1730942; rs1731076; rs7187850; rs35596444; rs8046003; rs28864687; rs1640990; rs12325121; rs8046571; rs9931939; rs8044285; rs7203755; rs41312250; rs8062725; rs28618356; rs13338663; rs7195524; rs28650912; rs35853974; rs34216922; rs13333072; rs10163342; rs12925473; rs1273379; rs7499024; rs1273387; rs5815492; rs13338551; rs7498949; rs34887951; rs28397834; rs7196287; rs28568507; rs2052235; rs34327953; rs34516341; rs28679855; rs35724649; rs11861413; rs7206673; rs2160181; rs1627524; rs35141742; rs1731077; rs1641114; rs13336886; rs12149463; rs35336676; rs34655579; rs9934284; rs35896679; rs1730940; rs8046260; rs1273375; rs28430948; rs3069301; rs35773832; rs28483683; rs5815493; rs11642744; rs8052663; rs1273389; rs12445001; rs35804023; rs35621836; rs1273392; rs3108683; rs34943374; rs1640982; rs35771183; rs4985115; rs1640976; rs1731088; rs12932819; rs35772192; rs34403809; rs34264472; rs9931477; rs8063475; rs1731024; rs11862275; rs36095894; rs753070; rs1273403; rs1298679; rs1630161; rs34085775; rs28785577; rs7192987; rs33948976; rs13337697; rs3069345; rs12924611; rs1731068; rs1465317; rs13339388; rs28557212; rs34198010; rs6497761; rs7188839; rs13337020; rs12921235; rs28669991; rs12598010; rs1078510; rs1320812; rs35617486; rs13338915; rs12445356; rs9674283; rs36191361; rs1273404; rs11647647; rs34543657; rs7198302; rs12924829; rs34544015; rs36181426; rs1627098; rs1731038; rs9923086; rs1273411; rs36055711; rs10153069; rs1641004; rs1731033; rs1657081; rs35468187; rs13337062; rs7200508; rs7185579; rs35255659; rs11649570; rs34994165; rs35503372; rs12598506; rs1641018; rs1731037; rs34598069; rs34415556; rs41307917; rs11648982; rs34761392; rs1273405; rs1548863; rs1641000; rs34630251; rs2464049; rs28568366; rs12930438; rs7205552; rs1299925; rs9941328; rs28759346; rs34495251; rs1641012; rs34900184; rs1629364; rs11862270; rs9936820; rs9926653; rs34177196; rs41312254; rs7200724; rs9932833; rs35002036; rs12935717; rs28852097; rs1273409; rs35359682; rs753072; rs10852270; rs28427346; rs35691630; rs11640314; rs10775276; rs1731025; rs28495577; rs34651404; rs34982194; rs35248639; rs36034133; rs1078508; rs12149630; rs35745596; rs9926200; rs36000891; rs7187363; rs8060324; rs7189861; rs13339115; rs35414822; rs34346487; rs35585805; rs41303767; rs35010946; rs933480; rs12447747; rs41305755; rs35405936; rs28630033; rs9941032; rs41427146; rs9922301; rs7191001; rs2313560; rs41312252; rs41311266; rs13338171; rs13339497; rs1641005; rs34408519; rs13380503; rs34755382; rs7500881; rs13335619; rs1273432; rs9936647; rs35893143; rs1273414; rs34060423; rs1623647; rs34484640; rs11647644; rs35548548; rs28398424; rs1730964; rs35258023; rs1730963; rs35440533; rs28758216; rs1060784; rs11641192; rs11860988; rs11861249; rs12103329; rs12444391; rs12444975; rs12447079; rs1273384; rs1273385; rs12929416; rs13338256; rs1345300; rs1358692; rs1641098; rs1641099; rs1641100; rs1641101; rs1865805; rs1865806; rs2160180; rs2241103; rs2312957; rs2840195; rs34611261; rs35851221; rs3743811; rs3743812; rs4985110; rs4985111; rs7188782; rs7192702; rs7200823; rs7204765; rs7205295; rs876945; rs9928906

# Macromolecular_Interacting_Partner_13_General_References:
7721088; 7851425; 10407778

# Macromolecular_Interacting_Partner_13_References:
16517019; 16539672; 16551461; 16777090

# Macromolecular_Interacting_Partner_14_ID:
5975

# Macromolecular_Interacting_Partner_14_Name:
Glutamate decarboxylase 2

# Macromolecular_Interacting_Partner_14_Synonyms:
Glutamate decarboxylase 65 kDa isoform; GAD-65; 65 kDa glutamic acid decarboxylase

# Macromolecular_Interacting_Partner_14_Gene_Name:
GAD2

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>Glutamate decarboxylase 2
MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGG
SQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQ
YVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFN
QLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFS
PGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVI
LIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIW
MHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQ
MHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEY
LYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEY
GTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
585

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
65412

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
6.89

# Macromolecular_Interacting_Partner_14_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_14_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_14_Specific_Function:
Catalyzes the production of GABA

# Macromolecular_Interacting_Partner_14_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00410  beta-Alanine metabolism;
 map00430  Taurine and hypotaurine metabolism;
 map00650  Butanoate metabolism

# Macromolecular_Interacting_Partner_14_Reaction:
L-glutamate = 4-aminobutanoate + CO2

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF00282:Pyridoxal_deC

# Macromolecular_Interacting_Partner_14_Signals:
None

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
EC 4.1.1.15

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
182934

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
DCE2_HUMAN (Q05329)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
GAD2

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
GAD2

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:4093

# Macromolecular_Interacting_Partner_14_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Cytoplasm; cytosol. Cytoplasmic vesicle. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>1758 bp
ATGGCATCTCCGGGCTCTGGCTTTTGGTCTTTCGGGTCGGAAGATGGCTCTGGGGATTCC
GAGAATCCCGGCACAGCGCGAGCCTGGTGCCAAGTGGCTCAGAAGTTCACGGGCGGCATC
GGAAACAAACTGTGCGCCCTGCTCTACGGAGACGCCGAGAAGCCGGCGGAGAGCGGCGGG
AGCCAACCCCCGCGGGCCGCCGCCCGGAAGGCCGCCTGCGCCTGCGACCAGAAGCCCTGC
AGCTGCTCCAAAGTGGATGTCAACTACGCGTTTCTCCATGCAACAGACCTGCTGCCGGCG
TGTGATGGAGAAAGGCCCACTTTGGCGTTTCTGCAAGATGTTATGAACATTTTACTTCAG
TATGTGGTGAAAAGTTTCGATAGATCAACCAAAGTGATTGATTTCCATTATCCTAATGAG
CTTCTCCAAGAATATAATTGGGAATTGGCAGACCAACCACAAAATTTGGAGGAAATTTTG
ATGCATTGCCAAACAACTCTAAAATATGCAATTAAAACAGGGCATCCTAGATACTTCAAT
CAACTTTCTACTGGTTTGGATATGGTTGGATTAGCAGCAGACTGGCTGACATCAACAGCA
AATACTAACATGTTCACCTATGAAATTGCTCCAGTATTTGTGCTTTTGGAATATGTCACA
CTAAAGAAAATGAGAGAAATCATTGGCTGGCCAGGGGGCTCTGGCGATGGGATATTTTCT
CCCGGTGGCGCCATATCTAACATGTATGCCATGATGATCGCACGCTTTAAGATGTTCCCA
GAAGTCAAGGAGAAAGGAATGGCTGCTCTTCCCAGGCTCATTGCCTTCACGTCTGAACAT
AGTCATTTTTCTCTCAAGAAGGGAGCTGCAGCCTTAGGGATTGGAACAGACAGCGTGATT
CTGATTAAATGTGATGAGAGAGGGAAAATGATTCCATCTGATCTTGAAAGAAGGATTCTT
GAAGCCAAACAGAAAGGGTTTGTTCCTTTCCTCGTGAGTGCCACAGCTGGAACCACCGTG
TACGGAGCATTTGACCCCCTCTTAGCTGTCGCTGACATTTGCAAAAAGTATAAGATCTGG
ATGCATGTGGATGCAGCTTGGGGTGGGGGATTACTGATGTCCCGAAAACACAAGTGGAAA
CTGAGTGGCGTGGAGAGGGCCAACTCTGTGACGTGGAATCCACACAAGATGATGGGAGTC
CCTTTGCAGTGCTCTGCTCTCCTGGTTAGAGAAGAGGGATTGATGCAGAATTGCAACCAA
ATGCATGCCTCCTACCTCTTTCAGCAAGATAAACATTATGACCTGTCCTATGACACTGGA
GACAAGGCCTTACAGTGCGGACGCCACGTTGATGTTTTTAAACTATGGCTGATGTGGAGG
GCAAAGGGGACTACCGGGTTTGAAGCGCATGTTGATAAATGTTTGGAGTTGGCAGAGTAT
TTATACAACATCATAAAAAACCGAGAAGGATATGAGATGGTGTTTGATGGGAAGCCTCAG
CACACAAATGTCTGCTTCTGGTACATTCCTCCAAGCTTGCGTACTCTGGAAGACAATGAA
GAGAGAATGAGTCGCCTCTCGAAGGTGGCTCCAGTGATTAAAGCCAGAATGATGGAGTAT
GGAACCACAATGGTCAGCTACCAACCCTTGGGAGACAAGGTCAATTTCTTCCGCATGGTC
ATCTCAAACCCAGCGGCAACTCACCAAGACATTGACTTCCTGATTGAAGAAATAGAACGC
CTTGGACAAGATTTATAA

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
M81882

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_14_Locus:
10p11.23

# Macromolecular_Interacting_Partner_14_SNPs:
rs2839672; rs2839678; rs1805397; rs2229845; rs7919405; rs1556234; rs3781106; rs8190809; rs1335547; rs3781105; rs3781107; rs8190811; rs8190812; rs8190817; rs8190816; rs8190800; rs8190590; rs8190813; rs8190805; rs8190801; rs7073217; rs8190802; rs8190814; rs8190807; rs8190815; rs8190803; rs992990; rs2368160; rs2368159; rs913963; rs913964; rs1999241; rs870341; rs928197; rs8190604; rs7906725; rs3781109; rs6482551; rs1330581; rs8190764; rs4749108; rs6482541; rs7897510; rs8190780; rs7071922; rs3893052; rs6482537; rs7073119; rs7900739; rs2839671; rs3781108; rs11015008; rs12267286; rs4994426; rs7893400; rs1330582; rs8190754; rs7087663; rs7900976; rs12414701; rs7074534; rs4144102; rs7074235; rs7068224; rs3847380; rs3781113; rs7902107; rs7076544; rs6482540; rs7913676; rs7908975; rs6482550; rs3781117; rs4747548; rs8190748; rs4749105; rs8190706; rs8190704; rs7087011; rs3781114; rs4749101; rs3847378; rs7893194; rs4747550; rs7913524; rs4749102; rs8190798; rs4749107; rs7095327; rs4747547; rs4747549; rs3847379; rs6482538; rs8190598; rs3824694; rs17667367; rs8190658; rs3781111; rs7081084; rs11015015; rs8190694; rs7897355; rs8190734; rs3904297; rs10828963; rs928198; rs913962; rs11015025; rs8190624; rs7099569; rs7918935; rs7072964; rs8190628; rs11015024; rs8190714; rs4749103; rs8190690; rs8190635; rs3781112; rs2839676; rs7909909; rs8190720; rs8190645; rs16926761; rs8190770; rs11594057; rs870342; rs6482544; rs7898281; rs1935996; rs8190708; rs8190716; rs3904298; rs8190597; rs8190779; rs3781116; rs12253114; rs8190660; rs7089304; rs3893253; rs7074934; rs2839675; rs8190796; rs4749104; rs12098763; rs7080514; rs8190685; rs7067571; rs6482543; rs7068510; rs8190611; rs12242971; rs1805398; rs7072137; rs8190689; rs8190646; rs11015010; rs11015028; rs8190718; rs2298124; rs2839674; rs8190713; rs7100268; rs6482548; rs7903208; rs7078680; rs1805399; rs8190678; rs8190701; rs8190612; rs3781118; rs3904296; rs8190637; rs8190683; rs8190673; rs8190782; rs7079102; rs6482542; rs11015004; rs12258601; rs12263667; rs7909902; rs8190620; rs8190650; rs7911425; rs6482547; rs913965; rs8190794; rs8190741; rs8190621; rs7895479; rs1330579; rs8190786; rs8190665; rs8190594; rs8190778; rs8190656; rs16926784; rs8190618; rs8190675; rs8190711; rs8190739; rs7091779; rs8190616; rs8190648; rs8190763; rs8190661; rs11015012; rs8190773; rs12248404; rs8190641; rs8190746; rs8190757; rs8190668; rs12358823; rs8190776; rs8190750; rs8190697; rs11015016; rs7067786; rs8190695; rs8190623; rs12258107; rs6482539; rs8190723; rs8190797; rs8190738; rs8190765; rs8190787; rs7915657; rs7912687; rs12251044; rs10828964; rs8190608; rs8190667; rs8190596; rs16926747; rs8190781; rs8190642; rs8190639; rs8190751; rs8190784; rs8190627; rs3781110; rs8190696; rs8190703; rs12254792; rs8190593; rs8190715; rs8190737; rs8190634; rs8190727; rs10160178; rs12098764; rs8190771; rs8190736; rs8190682; rs2839677; rs8190651; rs8190785; rs11015018; rs4111544; rs7911393; rs10466096; rs7080693; rs11015003; rs8190709; rs7909127; rs7922748; rs8190733; rs11015017; rs8190602; rs8190672; rs8190789; rs3904299; rs8190692; rs8190626; rs8190632; rs8190774; rs11015002; rs12243085; rs8190768; rs8190722; rs8190617; rs7905275; rs8190752; rs8190595; rs8190728; rs1330580; rs7893528; rs11015011; rs12360108; rs8190607; rs8190772; rs8190766; rs8190693; rs8190647; rs7089218; rs6482549; rs10466098; rs8190756; rs8190775; rs8190744; rs7914135; rs12243037; rs12240863; rs8190758; rs8190670; rs7076905; rs12269473; rs8190721; rs8190606; rs8190615; rs8190649; rs2236418; rs3758446; rs4749111; rs8190582; rs2839669; rs2839670; rs4747553; rs4749110; rs7090727; rs4747551; rs7090581; rs4747552; rs2236417; rs8190586; rs1065239; rs8190588; rs8190825; rs8190585; rs8190587; rs8190584; rs8190823; rs2839673; rs8190730; rs8190671; rs8190600; rs8190591; rs8190729; rs8190799; rs8190804; rs34587935; rs41279918; rs8190818; rs1360845; rs8190821; rs17847106; rs8190806; rs8190819; rs8190820; rs8190810; rs8190808; rs2210118; rs35598312; rs35399576; rs8190609; rs8190724; rs11015005; rs11015026; rs8190753; rs8190747; rs11812646; rs11015007; rs8190731; rs16926771; rs34544929; rs8190783; rs8190680; rs8190742; rs7914958; rs11424034; rs34446027; rs10706901; rs8190687; rs8190795; rs8190792; rs12242900; rs7912720; rs12765251; rs8190638; rs17847108; rs35729928; rs35302027; rs8190674; rs28411087; rs36068216; rs11015021; rs12413327; rs41279916; rs8190760; rs3831349; rs35525470; rs8190702; rs12240533; rs8190759; rs7077030; rs35027140; rs8190657; rs8190743; rs35001308; rs35095406; rs8190664; rs35193512; rs8190676; rs7898671; rs34460749; rs7910714; rs8190610; rs8190601; rs11015029; rs34165540; rs10571094; rs34714031; rs17847113; rs8190655; rs10466097; rs8190691; rs34544347; rs8190788; rs34492981; rs11397236; rs8190640; rs8190767; rs34551923; rs11015013; rs12240390; rs17847119; rs958295; rs7896603; rs8190613; rs11351928; rs8190793; rs35560251; rs8190777; rs12258225; rs4749109; rs35466733; rs8190619; rs12764007; rs8190677; rs8190712; rs8190684; rs8190652; rs8190761; rs11015023; rs8190717; rs3925895; rs12780466; rs35967087; rs10691988; rs41279914; rs8190654; rs35473617; rs7906622; rs8190622; rs8190699; rs8190700; rs35554915; rs8190790; rs8190614; rs34282513; rs7904959; rs35460917; rs35692804; rs35701656; rs5783968; rs41304597; rs8190740; rs11015030; rs7910604; rs12258527; rs4749100; rs8190755; rs12265834; rs7906659; rs7911822; rs8190681; rs11382565; rs10550716; rs8190726; rs41304609; rs7900313; rs12258214; rs8190599; rs11015014; rs8190633; rs8190605; rs11594128; rs7084058; rs8190643; rs35046451; rs7897227; rs35449881; rs11015009; rs35322930; rs35856372; rs35871778; rs11389512; rs8190636; rs11437464; rs8190653; rs35327186; rs35218393; rs8190745; rs34436183; rs11015006; rs35900771; rs8190732; rs8190735; rs12252062; rs7074897; rs8190791; rs8190725; rs8190666; rs8190669; rs8190631; rs8190707; rs8190679; rs8190749; rs34964656; rs34166651; rs35778757; rs8190719; rs8190710; rs8190686; rs35829665; rs11407523; rs8190625; rs11417128; rs8190659; rs36008357; rs16926745; rs8190698; rs8190769; rs11014999; rs8190603; rs8190705; rs7078821; rs11015027; rs8190762; rs8190644; rs4589175; rs8190589; rs8190822; rs8190583; rs34861013; rs10508715; rs11014998; rs11015031; rs11015032; rs11591556; rs12248143; rs12256696; rs12264198; rs12265385; rs1330574; rs16926835; rs16926836; rs1888251; rs2150157; rs2150158; rs2150159; rs2150160; rs2839668; rs7899642; rs7915415; rs7922791; rs8190828; rs8190830; rs876845; rs876846; rs876847; rs876848; rs882138; rs994502

# Macromolecular_Interacting_Partner_14_General_References:
1924293; 1549570; 8088791; 7680313; 8243826; 8999827; 12356867

# Macromolecular_Interacting_Partner_14_References:
16461938; 16569443; 16624944; 16787266

# Macromolecular_Interacting_Partner_15_ID:
7803

# Macromolecular_Interacting_Partner_15_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_15_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_15_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_15_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_15_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_15_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_15_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_15_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_15_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_15_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_15_Pathway:
Not Available

# Macromolecular_Interacting_Partner_15_Reaction:
Not Available

# Macromolecular_Interacting_Partner_15_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_15_Signals:
None

# Macromolecular_Interacting_Partner_15_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_15_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_15_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_15_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_15_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_15_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_15_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_15_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_15_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_15_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_15_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_15_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_15_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_15_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_15_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_15_SNPs:
Not Available

# Macromolecular_Interacting_Partner_15_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_15_References:
16417462; 16634430; 17147268

# Macromolecular_Interacting_Partner_16_ID:
7828

# Macromolecular_Interacting_Partner_16_Name:
Orexin precursor

# Macromolecular_Interacting_Partner_16_Synonyms:
Hypocretin; Hcrt[Contains: Orexin-A; Hypocretin- 1; Hcrt1; Orexin-B; Hypocretin-2; Hcrt2]

# Macromolecular_Interacting_Partner_16_Gene_Name:
HCRT

# Macromolecular_Interacting_Partner_16_Protein_Sequence:
>Orexin precursor
MNLPSTKVSWAAVTLLLLLLLLPPALLSSGAAAQPLPDCCRQKTCSCRLYELLHGAGNHA
AGILTLGKRRSGPPGLQGRLQRLLQASGNHAAGILTMGRRAGAEPAPRPCLGRRCSAPAA
ASVAPGGQSGI

# Macromolecular_Interacting_Partner_16_Number_of_Residues:
131

# Macromolecular_Interacting_Partner_16_Molecular_Weight:
13363

# Macromolecular_Interacting_Partner_16_Theoretical_pI:
11.35

# Macromolecular_Interacting_Partner_16_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  response to stimulus
Process:  behavior
Process:  feeding behavior
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
Process:  neuropeptide signaling pathway
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_16_General_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Specific_Function:
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity

# Macromolecular_Interacting_Partner_16_Pathway:
Not Available

# Macromolecular_Interacting_Partner_16_Reaction:
Not Available

# Macromolecular_Interacting_Partner_16_Pfam_Domain_Function:
PF02072:Orexin

# Macromolecular_Interacting_Partner_16_Signals:
1-33

# Macromolecular_Interacting_Partner_16_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_16_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_16_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_16_GenBank_ID_Protein:
2897118

# Macromolecular_Interacting_Partner_16_SwissProt_ID:
OREX_HUMAN (O43612)

# Macromolecular_Interacting_Partner_16_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_16_Genecard_id:
HCRT

# Macromolecular_Interacting_Partner_16_Geneatlas_id:
HCRT

# Macromolecular_Interacting_Partner_16_hgnc_id:
HGNC:4847

# Macromolecular_Interacting_Partner_16_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_16_Subcellular_Location:
Endoplasmic reticulum; rough endoplasmic reticulum. Cytoplasmic vesicle (By similarity). Cell junction; synapse (By similarity). Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses (By similarity)

# Macromolecular_Interacting_Partner_16_Gene_Sequence:
>396 bp
ATGAACCTTCCTTCCACAAAGGTCTCCTGGGCCGCCGTGACGCTACTGCTGCTGCTGCTG
CTGCTGCCGCCCGCGCTGTTGTCGTCCGGGGCGGCTGCACAGCCCCTGCCCGACTGCTGT
CGTCAAAAGACTTGCTCTTGCCGCCTCTACGAGCTGCTGCACGGCGCGGGCAATCACGCG
GCCGGCATCCTCACGCTGGGCAAGCGGAGGTCCGGGCCCCCGGGCCTCCAGGGTCGGCTG
CAGCGCCTCCTGCAGGCCAGCGGCAACCACGCCGCGGGCATCCTGACCATGGGCCGCCGC
GCAGGCGCAGAGCCAGCGCCGCGCCCCTGCCTCGGGCGCCGCTGTTCCGCCCCGGCCGCC
GCCTCCGTCGCGCCCGGAGGACAGTCCGGGATCTGA

# Macromolecular_Interacting_Partner_16_GenBank_ID_Gene:
AF041240

# Macromolecular_Interacting_Partner_16_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_16_Locus:
17q21

# Macromolecular_Interacting_Partner_16_SNPs:
rs9902709; rs8072099; rs8072081; rs760282; rs41513044; rs4796777; rs34727363; rs3760391; rs748442; rs34801573; rs748443; rs28879196; rs28696012; rs12953110; rs35725938; rs748444; rs3760390; rs36046844; rs4796776; rs1453402; rs28863552; rs5820451; rs34171118; rs34640131; rs12450953; rs12603630; rs2293153; rs3744485; rs3785901; rs7226205; rs9896975; rs9905193

# Macromolecular_Interacting_Partner_16_General_References:
9491897; 10364220; 10583376; 11340621; 11283317; 10973318

# Macromolecular_Interacting_Partner_16_References:
16627567; 17092492

# Macromolecular_Interacting_Partner_17_ID:
7841

# Macromolecular_Interacting_Partner_17_Name:
Major prion protein precursor

# Macromolecular_Interacting_Partner_17_Synonyms:
PrP; PrP27-30; PrP33-35C; ASCR; CD230 antigen

# Macromolecular_Interacting_Partner_17_Gene_Name:
PRNP

# Macromolecular_Interacting_Partner_17_Protein_Sequence:
>Major prion protein precursor
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQP
HGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGA
VVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCV
NITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPV
ILLISFLIFLIVG

# Macromolecular_Interacting_Partner_17_Number_of_Residues:
253

# Macromolecular_Interacting_Partner_17_Molecular_Weight:
27662

# Macromolecular_Interacting_Partner_17_Theoretical_pI:
9.23

# Macromolecular_Interacting_Partner_17_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_17_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_17_Specific_Function:
The physiological function of PrP is not known

# Macromolecular_Interacting_Partner_17_Pathway:
Not Available

# Macromolecular_Interacting_Partner_17_Reaction:
Not Available

# Macromolecular_Interacting_Partner_17_Pfam_Domain_Function:
PF00377:Prion;
PF03991:Prion_octapep

# Macromolecular_Interacting_Partner_17_Signals:
1-22

# Macromolecular_Interacting_Partner_17_Transmembrane_Regions:
112-134; 230-252

# Macromolecular_Interacting_Partner_17_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_17_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_17_GenBank_ID_Protein:
190468

# Macromolecular_Interacting_Partner_17_SwissProt_ID:
PRIO_HUMAN (P04156)

# Macromolecular_Interacting_Partner_17_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_17_Genecard_id:
PRNP

# Macromolecular_Interacting_Partner_17_Geneatlas_id:
PRNP

# Macromolecular_Interacting_Partner_17_hgnc_id:
HGNC:9449

# Macromolecular_Interacting_Partner_17_PDB_ID:
1QLZ

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_17_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Macromolecular_Interacting_Partner_17_Gene_Sequence:
>762 bp
ATGGCGAACCTTGGCTGCTGGATGCTGGTTCTCTTTGTGGCCACATGGAGTGACCTGGGC
CTCTGCAAGAAGCGCCCGAAGCCTGGAGGATGGAACACTGGGGGCAGCCGATACCCGGGG
CAGGGCAGCCCTGGAGGCAACCGCTACCCACCTCAGGGCGGTGGTGGCTGGGGGCAGCCT
CATGGTGGTGGCTGGGGGCAGCCTCATGGTGGTGGCTGGGGGCAGCCCCATGGTGGTGGC
TGGGGACAGCCTCATGGTGGTGGCTGGGGTCAAGGAGGTGGCACCCACAGTCAGTGGAAC
AAGCCGAGTAAGCCAAAAACCAACATGAAGCACATGGCTGGTGCTGCAGCAGCTGGGGCA
GTGGTGGGGGGCCTTGGCGGCTACATGCTGGGAAGTGCCATGAGCAGGCCCATCATACAT
TTCGGCAGTGACTATGAGGACCGTTACTATCGTGAAAACATGCACCGTTACCCCAACCAA
GTGTACTACAGGCCCATGGATGAGTACAGCAACCAGAACAACTTTGTGCACGACTGCGTC
AATATCACAATCAAGCAGCACACGGTCACCACAACCACCAAGGGGGAGAACTTCACCGAG
ACCGACGTTAAGATGATGGAGCGCGTGGTTGAGCAGATGTGTATCACCCAGTACGAGAGG
GAATCTCAGGCCTATTACCAGAGAGGATCGAGCATGGTCCTCTTCTCCTCTCCACCTGTG
ATCCTCCTGATCTCTTTCCTCATCTTCCTGATAGTGGGATGA

# Macromolecular_Interacting_Partner_17_GenBank_ID_Gene:
M13899

# Macromolecular_Interacting_Partner_17_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_17_Locus:
20p13

# Macromolecular_Interacting_Partner_17_SNPs:
rs1799990; rs16990018; rs8124214; rs6037932; rs6116471; rs13045348; rs6116475; rs6084833; rs6107516; rs6116474; rs2756268; rs12625220; rs6052768; rs6052772; rs6052769; rs6037931; rs11087653; rs1894284; rs2093390; rs2025113; rs2093391; rs7274758; rs6076715; rs2025112; rs1931969; rs4815729; rs2025114; rs6107515; rs6052771; rs6037933; rs11087654; rs16990011; rs6084832; rs11698714; rs12625444; rs2756271; rs11538769; rs11538764; rs28933385; rs17852079; rs11538753; rs11538758; rs11538768; rs11538767; rs11538756; rs11538762; rs11538766; rs1800014; rs11538755; rs11477517; rs11538754; rs11538759; rs11538763; rs6052773; rs11538765; rs6052775; rs35798066; rs34018918; rs6084831; rs11471790; rs11538760; rs5840051; rs4815730; rs41279420; rs6037934; rs7344736; rs11475157; rs13045887; rs6052774; rs6116472; rs7348058; rs2756270; rs6116470; rs34756298; rs34701827; rs8120718; rs35197124; rs35643278; rs8182868; rs6052767; rs35971722; rs13044114; rs6116473; rs7508980; rs2756269; rs8182841; rs34805351; rs8182830; rs6052766; rs1894282; rs6084835; rs6139520; rs6076716; rs14521; rs6076717; rs1894281; rs1894283; rs35519959; rs8182840; rs35481474; rs35256267; rs34193061; rs11477771; rs3054138; rs34209902; rs13040327; rs6084828; rs12624929; rs6084830; rs6084829; rs41279422; rs13042681; rs1885358; rs2065706; rs2181021; rs2756267; rs2855412; rs4378874; rs6037929; rs6037930; rs6037937; rs6037938; rs6052763; rs6052764; rs6052778; rs6052780; rs6052781; rs6052782; rs6076714; rs6084827; rs6084837; rs6084838; rs6084842; rs6084843; rs6107517; rs6107518; rs6116477; rs6116480; rs6116481; rs6133156; rs7264175; rs7360331; rs765470

# Macromolecular_Interacting_Partner_17_General_References:
3755672; 1678248; 9799790; 10581485; 11780052; 3014653; 1363802; 9384372; 7485229; 1672107; 1683708; 10618385; 10900000; 8364585; 8105771; 2564168; 2783132; 1347910; 1671440; 1975028; 1363810; 8461023; 7902693; 7902972; 7699395; 7906019; 7913755; 7783876; 8797472; 8909447; 9266722; 9786248; 10987652; 10631141; 11709001

# Macromolecular_Interacting_Partner_17_References:
16754670

# Macromolecular_Interacting_Partner_18_ID:
7745

# Macromolecular_Interacting_Partner_18_Name:
Gamma-aminobutyric-acid receptor subunit gamma-2 precursor

# Macromolecular_Interacting_Partner_18_Synonyms:
GABA(Areceptor subunit gamma-2

# Macromolecular_Interacting_Partner_18_Gene_Name:
GABRG2

# Macromolecular_Interacting_Partner_18_Protein_Sequence:
>Gammaaminobutyricacid receptor subunit gamma2 precursor
MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK
VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT
WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY
TLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQF
SFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDA
VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV
SNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCC
FEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL

# Macromolecular_Interacting_Partner_18_Number_of_Residues:
467

# Macromolecular_Interacting_Partner_18_Molecular_Weight:
54163

# Macromolecular_Interacting_Partner_18_Theoretical_pI:
8.60

# Macromolecular_Interacting_Partner_18_GO_Classification:
>>>
Function:  neurotransmitter receptor activity
Function:  transporter activity
Function:  ion transporter activity
Function:  ion channel activity
Function:  ligand-gated ion channel activity
Function:  extracellular ligand-gated ion channel activity
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  GABA receptor activity
Function:  GABA-A receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
Process:  gamma-aminobutyric acid signaling pathway
Process:  anion transport
Process:  inorganic anion transport
Process:  chloride transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
 ||
>>>
Component:  postsynaptic membrane
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_18_General_Function:
Not Available

# Macromolecular_Interacting_Partner_18_Specific_Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

# Macromolecular_Interacting_Partner_18_Pathway:
Not Available

# Macromolecular_Interacting_Partner_18_Reaction:
Not Available

# Macromolecular_Interacting_Partner_18_Pfam_Domain_Function:
PF02931:Neur_chan_LBD;
PF02932:Neur_chan_memb

# Macromolecular_Interacting_Partner_18_Signals:
1-39

# Macromolecular_Interacting_Partner_18_Transmembrane_Regions:
274-296
300-322
334-356
444-466

# Macromolecular_Interacting_Partner_18_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_18_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_18_GenBank_ID_Protein:
31637

# Macromolecular_Interacting_Partner_18_SwissProt_ID:
GBRG2_HUMAN (P18507)

# Macromolecular_Interacting_Partner_18_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_18_Genecard_id:
GABRG2

# Macromolecular_Interacting_Partner_18_Geneatlas_id:
GABRG2

# Macromolecular_Interacting_Partner_18_hgnc_id:
HGNC:4087

# Macromolecular_Interacting_Partner_18_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_18_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_18_Gene_Sequence:
>1404 bp
ATGAGTTCACCAAATATATGGAGCACAGGAAGCTCAGTCTACTCGACTCCTGTATTTTCA
CAGAAAATGACGGTGTGGATTCTGCTCCTGCTGTCGCTCTACCCTGGCTTCACTAGCCAG
AAATCTGATGATGACTATGAAGATTATGCTTCTAACAAAACATGGGTCTTGACTCCAAAA
GTTCCTGAGGGTGATGTCACTGTCATCTTAAACAACCTGCTGGAAGGATATGACAATAAA
CTTCGGCCTGATATAGGAGTGAAGCCAACGTTAATTCACACAGACATGTATGTGAATAGC
ATTGGTCCAGTGAACGCTATCAATATGGAATACACTATTGATATATTTTTTGCGCAAATG
TGGTATGACAGACGTTTGAAATTTAACAGCACCATTAAAGTCCTCCGATTGAACAGCAAC
ATGGTGGGGAAAATCTGGATTCCAGACACTTTCTTCAGAAATTCCAAAAAAGCTGATGCA
CACTGGATCACCACCCCCAACAGGATGCTGAGAATTTGGAATGATGGTCGAGTGCTCTAC
TCCCTAAGGTTGACAATTGATGCTGAGTGCCAATTACAATTGCACAATTTTCCAATGGAT
GAACACTCCTGCCCCTTGGAGTTCTCCAGTTATGGCTATCCACGTGAAGAAATTGTTTAT
CAATGGAAGCGAAGTTCTGTTGAAGTGGGCGACACAAGATCCTGGAGGCTTTATCAATTC
TCATTTGTTGGTCTAAGAAATACCACCGAAGTAGTGAAGACAACTTCCGGAGATTATGTG
GTCATGTCTGTCTACTTTGATCTGAGCAGAAGAATGGGATACTTTACCATCCAGACCTAT
ATCCCCTGCACACTCATTGTCGTCCTATCCTGGGTGTCTTTCTGGATCAATAAGGATGCT
GTTCCAGCCAGAACATCTTTAGGTATCACCACTGTCCTGACAATGACCACCCTCAGCACC
ATTGCCCGGAAATCGCTCCCCAAGGTCTCCTATGTCACAGCGATGGATCTCTTTGTATCT
GTTTGTTTCATCTTTGTCTTCTCTGCTCTGGTGGAGTATGGCACCTTGCATTATTTTGTC
AGCAACCGGAAACCAAGCAAGGACAAAGATAAAAAGAAGAAAAACCCTGCCCCTACCATT
GATATCCGCCCAAGATCAGCAACCATTCAAATGAATAATGCTACACACCTTCAAGAGAGA
GATGAAGAGTACGGCTATGAGTGTCTGGACGGCAAGGACTGTGCCAGTTTTTTCTGCTGT
TTTGAAGATTGTCGAACAGGAGCTTGGAGACATGGGAGGATACATATCCGCATTGCCAAA
ATGGACTCCTATGCTCGGATCTTCTTCCCCACTGCCTTCTGCCTGTTTAATCTGGTCTAT
TGGGTCTCCTACCTCTACCTGTGA

# Macromolecular_Interacting_Partner_18_GenBank_ID_Gene:
X15376

# Macromolecular_Interacting_Partner_18_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_18_Locus:
5q31.1-q33.1

# Macromolecular_Interacting_Partner_18_SNPs:
rs211037; rs11135176; rs209358; rs183294; rs209350; rs209354; rs2910223; rs418210; rs424740; rs209353; rs209357; rs211017; rs209348; rs2268583; rs209347; rs11956247; rs1997583; rs11742028; rs11958269; rs209352; rs3797863; rs3219203; rs2963169; rs2268582; rs3797860; rs209356; rs2910062; rs13154832; rs7702288; rs11958242; rs17060039; rs7730798; rs209355; rs3797861; rs479294; rs3797862; rs17060038; rs11950672; rs209351; rs7714104; rs209346; rs13174392; rs3115739; rs2284782; rs365054; rs211013; rs211029; rs169792; rs989694; rs210982; rs398690; rs2205364; rs766349; rs2103475; rs210983; rs10079477; rs211014; rs721719; rs2272600; rs211030; rs454888; rs2422106; rs211015; rs210989; rs387661; rs210991; rs440218; rs211036; rs17462431; rs210981; rs10491328; rs211031; rs17060096; rs1422827; rs12520992; rs169793; rs210988; rs17060118; rs10491330; rs10055965; rs10052464; rs211032; rs17060101; rs411409; rs2223090; rs210985; rs387556; rs210990; rs10491329; rs1422826; rs211034; rs13173675; rs17060112; rs184135; rs2268581; rs188379; rs10069323; rs211033; rs2964616; rs17462459; rs211035; rs17060077; rs17060111; rs6893138; rs2161409; rs365359; rs17060103; rs17060106; rs210986; rs977412; rs17572158; rs12520033; rs210979; rs210980; rs387554; rs210984; rs3797866; rs210987; rs436816; rs9313908; rs10072226; rs7728001; rs647625; rs401750; rs17855003; rs17855004; rs2178932; rs35469674; rs34469408; rs381647; rs5872743; rs5019608; rs209349; rs7713739; rs3216599; rs11327478; rs426978; rs34352711; rs34496139; rs34705786; rs41275341; rs7735226; rs35315145; rs2963170; rs5872746; rs34565945; rs2284781; rs10672843; rs35962499; rs431201; rs2284783; rs3216598; rs35764415; rs13179628; rs1990956; rs3079252; rs33931964; rs34809383; rs13166868; rs35748294; rs450549; rs35700692; rs34269152; rs3180569; rs1363637; rs33913218; rs28672781; rs13177714; rs191892; rs5872742; rs5019611; rs34324460; rs5872747; rs11343344; rs35985419; rs35587210; rs34161555; rs2284784; rs35128025; rs28693828; rs34053657; rs36112889; rs13168345; rs33958814; rs41304898; rs35867676; rs35887658; rs33955804; rs35691477; rs211016; rs2963168; rs13171631; rs34987164; rs41311629; rs5872749; rs35239213; rs34038866; rs960673; rs35683736; rs35833342; rs34493885; rs13164026; rs35298553; rs35999351; rs34938012; rs35072787; rs3839306; rs34781222; rs11397950; rs10058192; rs2910224; rs35828738; rs7715656; rs7445871; rs34861510; rs28594438; rs3839308; rs10073724; rs9313911; rs11575991; rs17572310; rs34902091; rs2422105; rs11575990; rs34083256; rs11280887; rs1114323; rs10650652; rs36006629; rs28550487; rs13181691; rs35750805; rs5872748; rs10066759; rs34875047; rs7730235; rs34752702; rs3839307; rs35439602; rs33995879; rs1882909; rs3797870; rs13163986; rs11575992; rs17060115; rs34354554; rs34554692; rs35294821; rs35915499; rs10644742; rs35649872; rs35610813; rs35982122; rs10066272; rs34281163; rs10665220; rs35039926; rs36076040; rs28660248; rs35905265; rs10569256; rs35339412; rs41303360; rs10052588; rs12514373; rs1422828; rs1422829; rs17462576; rs17462590; rs17462597; rs17548793; rs17572394; rs209337; rs209338; rs209341; rs209345; rs211010; rs211012; rs3756626; rs6886028; rs987580

# Macromolecular_Interacting_Partner_18_General_References:
2538761; 9892355; 11326274; 11326275

# Macromolecular_Interacting_Partner_18_References:
16829199

# Macromolecular_Interacting_Partner_19_ID:
8352

# Macromolecular_Interacting_Partner_19_Name:
Parvalbumin alpha

# Macromolecular_Interacting_Partner_19_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_19_Gene_Name:
PVALB

# Macromolecular_Interacting_Partner_19_Protein_Sequence:
>Parvalbumin alpha
MSMTDLLNAEDIKKAVGAFSATDSFDHKKFFQMVGLKKKSADDVKKVFHMLDKDKSGFIE
EDELGFILKGFSPDARDLSAKETKMLMAAGDKDGDGKIGVDEFSTLVAES

# Macromolecular_Interacting_Partner_19_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_19_Molecular_Weight:
12059

# Macromolecular_Interacting_Partner_19_Theoretical_pI:
4.78

# Macromolecular_Interacting_Partner_19_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_19_General_Function:
Not Available

# Macromolecular_Interacting_Partner_19_Specific_Function:
In muscle, the calcium-binding protein parvalbumin is thought to be involved in muscle relaxation

# Macromolecular_Interacting_Partner_19_Pathway:
Not Available

# Macromolecular_Interacting_Partner_19_Reaction:
Not Available

# Macromolecular_Interacting_Partner_19_Pfam_Domain_Function:
PF00036:efhand

# Macromolecular_Interacting_Partner_19_Signals:
None

# Macromolecular_Interacting_Partner_19_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_19_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_19_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_19_GenBank_ID_Protein:
35808

# Macromolecular_Interacting_Partner_19_SwissProt_ID:
PRVA_HUMAN (P20472)

# Macromolecular_Interacting_Partner_19_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_19_Genecard_id:
PVALB

# Macromolecular_Interacting_Partner_19_Geneatlas_id:
PVALB

# Macromolecular_Interacting_Partner_19_hgnc_id:
HGNC:9704

# Macromolecular_Interacting_Partner_19_PDB_ID:
1RK9

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_19_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_19_Gene_Sequence:
>327 bp
ATGTCGATGACAGACTTGCTGAACGCTGAGGACATCAAGAAGGCGGTGGGAGCCTTTAGC
GCTACCGACTCCTTCGACCACAAAAAGTTCTTCCAAATGGTCGGCCTGAAGAAAAAGAGT
GCGGATGATGTGAAGAAGGTGTTTCACATGCTGGACAAGGACAAAAGTGGCTTCATCGAG
GAGGATGAGCTGGGATTCATCCTAAAAGGCTTCTCCCCAGATGCCAGAGACCTGTCTGCT
AAAGAAACCAAGATGCTGATGGCTGCTGGAGACAAAGATGGGGACGGCAAAATTGACGAA
TTCTCCACTCTGGTGGCTGAAAGCTAA

# Macromolecular_Interacting_Partner_19_GenBank_ID_Gene:
X63578

# Macromolecular_Interacting_Partner_19_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_19_Locus:
22q12-q13.1|22q13.1

# Macromolecular_Interacting_Partner_19_SNPs:
rs3484; rs2284026; rs2284025; rs12483924; rs5750313; rs762917; rs2001063; rs736720; rs12171125; rs4820252; rs1894479; rs2022068; rs6519035; rs739031; rs9610587; rs5750309; rs4820250; rs6519034; rs9622488; rs2284022; rs5750310; rs4821536; rs13057042; rs2071709; rs4821535; rs7511216; rs4820249; rs2067069; rs4820255; rs4821532; rs4821531; rs7288290; rs2269512; rs11913972; rs736721; rs2269511; rs2284021; rs4821534; rs762920; rs4820253; rs2284023; rs6000426; rs11913267; rs2284024; rs4820254; rs4820251; rs2284019; rs5750311; rs2067068; rs13057439; rs10775741; rs13056258; rs2413421; rs2001064; rs4239881; rs4820248; rs2413423; rs2267362; rs2227064; rs2413422; rs5756345; rs5756349; rs5756347; rs5756346; rs4820247; rs17810287; rs2213429; rs4821529; rs4820246; rs4821530; rs4821528; rs1131432; rs35095499; rs34926114; rs9607383; rs34561646; rs34159767; rs9622489; rs11703317; rs7286330; rs6000427; rs4821533; rs12053777; rs7287999; rs5004490; rs4084292; rs7290425; rs5845300; rs12159841; rs35988819; rs13055296; rs7287559; rs13054448; rs5750312; rs11913511; rs13055625; rs10599854; rs28372402; rs12168594; rs28473514; rs11705163; rs4820256; rs34281373; rs5756351; rs35724962; rs12159680; rs10605026; rs35805671; rs5845302; rs12483785; rs34262500; rs7290723; rs11370531; rs4414767; rs36215449; rs9610586; rs4630865; rs2284020; rs5756350; rs7410360; rs5756353; rs12330085; rs9610585; rs5845299; rs5995346; rs5750314; rs9610588; rs5756348; rs6000428; rs2227065; rs12159863; rs17810645; rs28582101; rs4616572; rs5756354; rs5756357; rs5756363; rs6000425; rs6650880; rs9607382; rs9610583; rs9619636

# Macromolecular_Interacting_Partner_19_General_References:
2614829; 8354278; 10591208; 10036163

# Macromolecular_Interacting_Partner_19_References:
16413119; 16420437; 16720092; 17030651

# Macromolecular_Interacting_Partner_20_ID:
8319

# Macromolecular_Interacting_Partner_20_Name:
Sodium- and chloride-dependent GABA transporter 1

# Macromolecular_Interacting_Partner_20_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_20_Gene_Name:
SLC6A1

# Macromolecular_Interacting_Partner_20_Protein_Sequence:
>Sodium and chloridedependent GABA transporter 1
MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLALKGSLKQRIQVMVQPSEDTVRPENGPEHAQAGSSTSKEAYI

# Macromolecular_Interacting_Partner_20_Number_of_Residues:
599

# Macromolecular_Interacting_Partner_20_Molecular_Weight:
67015

# Macromolecular_Interacting_Partner_20_Theoretical_pI:
8.16

# Macromolecular_Interacting_Partner_20_GO_Classification:
>>>
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
Function:  transporter activity
Function:  organic acid transporter activity
Function:  organic acid:sodium symporter activity
Function:  sodium:amino acid symporter activity
Function:  gamma-aminobutyric acid:sodium symporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_20_General_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Specific_Function:
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals

# Macromolecular_Interacting_Partner_20_Pathway:
Not Available

# Macromolecular_Interacting_Partner_20_Reaction:
Not Available

# Macromolecular_Interacting_Partner_20_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_20_Signals:
None

# Macromolecular_Interacting_Partner_20_Transmembrane_Regions:
53-73
81-100
124-144
212-230
239-256
292-309
321-342
375-394
422-440
457-477
498-517
536-554

# Macromolecular_Interacting_Partner_20_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_20_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_20_GenBank_ID_Protein:
31658

# Macromolecular_Interacting_Partner_20_SwissProt_ID:
SC6A1_HUMAN (P30531)

# Macromolecular_Interacting_Partner_20_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_20_Genecard_id:
SLC6A1

# Macromolecular_Interacting_Partner_20_Geneatlas_id:
SLC6A1

# Macromolecular_Interacting_Partner_20_hgnc_id:
HGNC:11042

# Macromolecular_Interacting_Partner_20_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_20_Subcellular_Location:
Cell membrane; multi-pass membrane protein. Membrane; multi-pass membrane protein. Note=Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons

# Macromolecular_Interacting_Partner_20_Gene_Sequence:
>1800 bp
ATGGCGACCAACGGCAGCAAGGTGGCCGACGGGCAGATCTCCACCGAGGTCAGCGAGGCC
CCTGTGGCCAATGACAAGCCCAAAACCTTGGTGGTCAAGGTGCAGAAGAAGGCGGCAGAC
CTCCCCGACCGGGACACGTGGAAGGGCCGCTTCGACTTCCTCATGTCCTGTGTGGGCTAT
GCCATCGGCCTGGGCAACGTCTGGAGGTTCCCCTATCTCTGCGGGAAAAATGGTGGGGGA
GCCTTCCTGATCCCCTATTTCCTGACACTCATCTTTGCGGGGGTCCCACTCTTCCTGCTG
GAGTGCTCCCTGGGCCAGTACACCTCCATCGGGGGGCTAGGGGTATGGAAGCTGGCTCCT
ATGTTCAAGGGCGTGGGCCTTGCGGCTGCTGTGCTATCATTCTGGCTGAACATCTACTAC
ATCGTCATCATCTCCTGGGCCATTTACTACCTGTACAACTCCTTCACCACGACACTGCCG
TGGAAACAGTGCGACAACCCCTGGAACACAGACCGCTGCTTCTCCAACTACAGCATGGTC
AACACTACCAACATGACCAGCGCTGTGGTGGAGTTCTGGGAGCGCAACATGCATCAGATG
ACGGACGGGCTGGATAAGCCAGGTCAGATCCGCTGGCCACTGGCCATCACGCTGGCCATC
GCCTGGATCCTTGTGTATTTCTGTATCTGGAAGGGTGTTGGCTGGACTGGAAAGGTGGTC
TACTTTTCAGCCACATACCCCTACATCATGCTGATCATCCTGTTCTTCCGTGGAGTGACG
CTGCCCGGGGCCAAGGAGGGCATCCTCTTCTACATCACACCCAACTTCCGCAAGCTGTCT
GACTCCGAGGTGTGGCTGGATGCGGCAACCCAGATCTTCTTCTCATACGGGCTGGGCCTG
GGGTCCCTGATCGCTCTCGGGAGCTACAACTCTTTCCACAACAATGTCTACAGGGACTCC
ATCATCGTCTGCTGCATCAATTCGTGCACCAGCATGTTCGCAGGATTCGTCATCTTCTCC
ATCGTGGGCTTCATGGCCCATGTCACCAAGAGGTCCATTGCTGATGTGGCCGCCTCAGGC
CCCGGGCTGGCGTTCCTGGCATACCCAGAGGCGGTGACCCAGCTGCCTATCTCCCCACTC
TGGGCCATCCTCTTCTTCTCCATGCTGTTGATGCTGGGCATTGACAGCCAGTTCTGCACT
GTGGAGGGCTTCATCACAGCCCTGGTGGATGAGTACCCCAGGCTCCTCCGCAACCGCAGA
GAGCTCTTCATTGCTGCTGTCTGCATCATCTCCTACCTGATCGGTCTCTCTAACATCACT
CAGGGGGGTATTTATGTCTTCAAACTCTTTGACTACTACTCTGCCAGTGGCATGAGCCTG
CTGTTCCTCGTGTTCTTTGAATGTGTCTCTATTTCCTGGTTTTACGGTGTCAACCGATTC
TATGACAATATCCAAGAGATGGTTGGATCCAGGCCCTGCATCTGGTGGAAACTCTGCTGG
TCTTTCTTCACACCAATCATTGTGGCGGGCGTGTTCATTTTCAGTGCTGTGCAGATGACG
CCACTCACCATGGGAAACTATGTTTTCCCCAAGTGGGGCCAGGGTGTGGGCTGGCTGATG
GCTCTGTCTTCCATGGTCCTCATCCCCGGGTACATGGCCTACATGTTCCTCGCCCTAAAG
GGCTCCCTGAAGCAGCGCATCCAAGTCATGGTCCAGCCCAGCGAAGACACTGTTCGCCCA
GAGAATGGTCCTGAGCACGCCCAGGCGGGCAGCTCCACCAGCAAGGAGGCCTACATCTAG


# Macromolecular_Interacting_Partner_20_GenBank_ID_Gene:
X54673

# Macromolecular_Interacting_Partner_20_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_20_Locus:
3p25-p24

# Macromolecular_Interacting_Partner_20_SNPs:
rs2272404; rs33948309; rs6344; rs2272401; rs6343; rs1710887; rs2928079; rs1710891; rs2933308; rs2930154; rs2675166; rs2944367; rs1710898; rs2675165; rs1568074; rs720352; rs1062246; rs1710892; rs1170695; rs6766999; rs9863701; rs2933309; rs9855272; rs1728816; rs9821726; rs6778281; rs1710897; rs1710890; rs6780165; rs1728817; rs1728814; rs4684055; rs2601126; rs1710880; rs6442218; rs2933310; rs2950800; rs2697149; rs6766512; rs11707097; rs9821288; rs1919075; rs1728811; rs4684054; rs3732944; rs2675161; rs2697144; rs2675160; rs7613535; rs11718132; rs9990174; rs17466478; rs1728815; rs1728807; rs11710097; rs6342; rs1170694; rs1710881; rs1710886; rs11710497; rs2930138; rs2697146; rs17466644; rs2697142; rs41276505; rs17033824; rs1617523; rs7629093; rs1170696; rs2675159; rs6789420; rs6804165; rs2944366; rs13320265; rs1710885; rs2697145; rs1728806; rs7645218; rs2944365; rs11919775; rs2933311; rs1568073; rs17601884; rs17033808; rs34189945; rs2697148; rs6766500; rs2697150; rs2601125; rs2933307; rs4038396; rs9879137; rs3817585; rs2697136; rs17532365; rs3856786; rs2697135; rs1028152; rs3856787; rs6780064; rs9821628; rs2246543; rs11925331; rs2950798; rs11719645; rs2272403; rs9876005; rs1728803; rs11708202; rs9310373; rs2272402; rs6770472; rs2675163; rs1728802; rs10510403; rs1710888; rs9836017; rs9822125; rs17033838; rs2928077; rs11712912; rs17033829; rs10514669; rs2928078; rs3774070; rs2675164; rs2697134; rs3817584; rs11711646; rs9819882; rs11290120; rs6341; rs12107996; rs3841958; rs2697138; rs7643585; rs1728818; rs2675156; rs2928080; rs2067382; rs2675157; rs1400154; rs2928081; rs17855574; rs1139554; rs17853248; rs35513423; rs34201135; rs2675167; rs2933313; rs35456709; rs10696522; rs11425810; rs34389160; rs13076117; rs35265541; rs41293373; rs7431276; rs10710996; rs35119915; rs35964686; rs2675158; rs2077135; rs1062616; rs11710192; rs1062237; rs11280487; rs1568072; rs34884581; rs6766948; rs2933312; rs34937975; rs11706135; rs7650969; rs1105781; rs41429044; rs5846691; rs11319908; rs34458709; rs2077136; rs35997142; rs11923810; rs34408917; rs2930155; rs2601124; rs11319907; rs35743928; rs35862296; rs34236722; rs2944364; rs2204689; rs34990229; rs2930137; rs35322516; rs28562799; rs41362845; rs10711832; rs2697147; rs2944363; rs11288671; rs35849758; rs17033816; rs41510044; rs41293365; rs34530325; rs41391147; rs9869358; rs41517144; rs41497953; rs41444444; rs41293369; rs41422847; rs41381549; rs2697140; rs41370144; rs35486441; rs41293371; rs41426745; rs3774069; rs35910232; rs34536989; rs10702772; rs2928076; rs34939196; rs2697141; rs9878778; rs34279235; rs41506145; rs9827626; rs41308232; rs10663120; rs41537851; rs35855996; rs41388950; rs6799755; rs9825337; rs9874325; rs2697139; rs41486951; rs35518745; rs34543552; rs41386254; rs41276503; rs35731717; rs1710882; rs41436650; rs1710889; rs35278682; rs41293367; rs41524646; rs41478447; rs2697137; rs41323844; rs35244184; rs9874479; rs10662859; rs41335049; rs35504380; rs35994749; rs41480248; rs41342644; rs34428600; rs34937215; rs35296635; rs1710873; rs41338544; rs41469948; rs2697151; rs13092196; rs12019231; rs34317261; rs10470635; rs11719708; rs12185978; rs12186082; rs1400155; rs1630696; rs1710874; rs1710875; rs1710876; rs1710877; rs1710878; rs1710879; rs1728819; rs1728820; rs1728821; rs17467186; rs1919076; rs2343224; rs2928082; rs2930151; rs2930152; rs36034065; rs4282038; rs4572751; rs4684752; rs6794616; rs6794626; rs7650199; rs9682960; rs9814213; rs9844030

# Macromolecular_Interacting_Partner_20_General_References:
2387399

# Macromolecular_Interacting_Partner_20_References:
16462035; 16466645; 16517017; 16641366

# Macromolecular_Interacting_Partner_21_ID:
7764

# Macromolecular_Interacting_Partner_21_Name:
Sodium- and chloride-dependent GABA transporter 3

# Macromolecular_Interacting_Partner_21_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_21_Gene_Name:
SLC6A11

# Macromolecular_Interacting_Partner_21_Protein_Sequence:
>Sodium and chloridedependent GABA transporter 3
MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFV
LSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGIT
CWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENC
VEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICY
FCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWV
DAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMA
YEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVT
AVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVA
IFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKY
NNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKL
GVSPRMVTVNDCDAKLKSDGTIAAITEKETHF

# Macromolecular_Interacting_Partner_21_Number_of_Residues:
632

# Macromolecular_Interacting_Partner_21_Molecular_Weight:
70607

# Macromolecular_Interacting_Partner_21_Theoretical_pI:
6.89

# Macromolecular_Interacting_Partner_21_GO_Classification:
>>>
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
Function:  transporter activity
Function:  organic acid transporter activity
Function:  organic acid:sodium symporter activity
Function:  sodium:amino acid symporter activity
Function:  gamma-aminobutyric acid:sodium symporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_21_General_Function:
Not Available

# Macromolecular_Interacting_Partner_21_Specific_Function:
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals

# Macromolecular_Interacting_Partner_21_Pathway:
Not Available

# Macromolecular_Interacting_Partner_21_Reaction:
Not Available

# Macromolecular_Interacting_Partner_21_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_21_Signals:
None

# Macromolecular_Interacting_Partner_21_Transmembrane_Regions:
59-79
87-106
131-151
226-244
253-270
306-323
335-356
389-408
438-456
473-493
514-533
553-571

# Macromolecular_Interacting_Partner_21_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_21_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_21_GenBank_ID_Protein:
913242

# Macromolecular_Interacting_Partner_21_SwissProt_ID:
S6A11_HUMAN (P48066)

# Macromolecular_Interacting_Partner_21_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_21_Genecard_id:
SLC6A11

# Macromolecular_Interacting_Partner_21_Geneatlas_id:
SLC6A11

# Macromolecular_Interacting_Partner_21_hgnc_id:
HGNC:11044

# Macromolecular_Interacting_Partner_21_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_21_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_21_Gene_Sequence:
>1899 bp
ATGACGGCGGAGAAGGCGCTGCCCCTGGGCAATGGGAAGGCTGCTGAGGAGGCGCGGGAG
TCCGAGGCGCCGGGTGGCGGCTGCAGCAGCGGGGGCGCGGCGCCCGCGCGCCACCCGCGC
GTCAAGCGCGACAAGGCGGTCCACGAGCGCGGCCACTGGAACAACAAGGTGGAGTTCGTG
CTGAGCGTGGCCGGGGAGATCATTGGGCTGGGCAACGTGTGGCGCTTCCCCTACCTGTGC
TACAAGAACGGAGGAGGGGCATTCCTGATTCCCTACGTGGTGTTTTTTATTTGCTGTGGA
ATTCCTGTTTTTTTCCTGGAGACAGCTCTGGGGCAGTTCACAAGTGAAGGTGGCATTACG
TGTTGGAGGAAAGTTTGCCCTTTATTTGAAGGCATTGGCTATGCAACACAGGTGATTGAG
GCCCATCTGAATGTGTACTACATCATCATCCTGGCATGGGCCATTTTTTACCTGAGCAAC
TGCTTCACTACTGAGCTACCCTGGGCTACCTGTGGGCATGAGTGGAACACAGAGAATTGT
GTGGAGTTCCAGAAACTGAATGTGAGCAACTACAGCCATGTGTCTCTGCAGAATGCCACC
TCCCCTGTCATGGAGTTTTGGGAGCACCGGGTCCTGGCCATCTCTGACGGGATCGAGCAC
ATCGGGAACCTTCGCTGGGAGCTGGCCTTGTGTCTCTTGGCAGCCTGGACCATCTGTTAC
TTCTGTATCTGGAAGGGGACCAAGTCTACAGGAAAGGTTGTATACGTGACTGCGACATTC
CCCTACATCATGCTGCTGATCCTCCTGATACGAGGGGTCACGTTGCCCGGGGCCTCAGAG
GGCATCAAGTTCTACTTGTACCCTGACCTCTCCCGGCTCTCCGACCCCCAGGTCTGGGTA
GATGCTGGAACGCAGATCTTTTTCTCCTATGCCATTTGCCTGGGCTGTCTGACCGCTCTG
GGAAGTTATAACAATTATAACAACAACTGCTACAGGGACTGCATCATGCTCTGTTGCCTG
AACAGCGGCACCAGCTTCGTGGCTGGGTTTGCCATCTTCTCAGTCCTGGGTTTTATGGCG
TACGAGCAGGGGGTACCCATTGCTGAGGTGGCAGAGTCAGGCCCCGGCCTGGCCTTTATT
GCGTACCCCAAGGCGGTCACCATGATGCCTCTCTCCCCGCTGTGGGCCACCTTGTTCTTC
ATGATGCTCATCTTCCTGGGCCTGGACAGCCAGTTTGTGTGTGTGGAAAGCCTGGTGACC
GCCGTGGTGGACATGTACCCCAAGGTTTTCCGGAGGGGTTACCGGCGGGAGCTGCTCATC
CTAGCCTTGTCTGTTATCTCCTATTTTCTGGGCCTCGTGATGTTAACAGAGGGTGGCATG
TACATCTTCCAGCTCTTTGACTCCTATGCCGCCAGTGGGATGTGCCTTCTCTTCGTGGCC
ATCTTTGAGTGCATCTGCATCGGCTGGGTGTATGGAAGCAACCGGTTCTATGATAACATT
GAAGACATGATTGGCTACCGGCCACCGTCGCTCATTAAGTGGTGCTGGATGATCATGACC
CCTGGGATCTGCGCGGGGATCTTCATCTTCTTCTTGATCAAGTACAAGCCACTCAAGTAC
AACAACATCTACACCTACCCAGCCTGGGGCTATGGCATTGGCTGGCTCATGGCCCTGTCC
TCCATGCTCTGCATCCCGCTCTGGATCTGCATCACAGTGTGGAAGACGGAGGGGACACTG
CCCGAGAAACTCCAGAAGTTGACGACCCCCAGCACAGATCTGAAAATGCGGGGCAAGCTT
GGGGTGAGCCCACGGATGGTGACAGTTAATGACTGTGATGCCAAACTCAAGAGTGACGGG
ACCATCGCAGCCATCACAGAGAAGGAGACGCACTTCTGA

# Macromolecular_Interacting_Partner_21_GenBank_ID_Gene:
S75989

# Macromolecular_Interacting_Partner_21_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_21_Locus:
3p25.3

# Macromolecular_Interacting_Partner_21_SNPs:
rs2304725; rs2245532; rs2272395; rs2272400; rs2272394; rs7620415; rs1601369; rs1610180; rs2343246; rs746278; rs2655278; rs1580441; rs2880586; rs1485142; rs2629133; rs1881367; rs6442209; rs1960131; rs2581206; rs1881364; rs3821761; rs1872392; rs2581211; rs2596847; rs11715462; rs2697161; rs1881354; rs4684740; rs7628912; rs6442211; rs2697159; rs2046423; rs3774113; rs4684742; rs7619622; rs736078; rs2938399; rs1807101; rs9835618; rs2272399; rs1485143; rs7628928; rs958469; rs6799474; rs2629127; rs2581210; rs750784; rs2655281; rs6442214; rs1994260; rs2254794; rs2697166; rs4684739; rs9835411; rs3821757; rs1485144; rs6809562; rs2697155; rs1601371; rs3774123; rs1586261; rs971930; rs2581205; rs3774130; rs4434127; rs2254931; rs1881366; rs7611534; rs1881369; rs2928074; rs3821767; rs746657; rs2629130; rs7614953; rs3774086; rs2629129; rs2697160; rs2017660; rs11128532; rs4481143; rs7631448; rs3774116; rs9878482; rs7612377; rs1881371; rs1881370; rs6795890; rs7617062; rs17033655; rs3774112; rs901031; rs9868537; rs4684052; rs750175; rs11714018; rs4684743; rs2581215; rs1545905; rs3774118; rs12634953; rs3774098; rs6442208; rs6798171; rs17033650; rs3774097; rs9812379; rs11709729; rs4684746; rs1843278; rs11717388; rs2697156; rs17033550; rs11714586; rs7618049; rs3774114; rs2655280; rs2629131; rs11719338; rs11918616; rs11715332; rs2581207; rs3774119; rs17033503; rs901029; rs12630119; rs2950806; rs3774110; rs2697162; rs3774104; rs2655274; rs2655283; rs1881365; rs11128533; rs2629128; rs3774108; rs9826851; rs7650590; rs11929187; rs2880585; rs11920286; rs2697158; rs11928687; rs901033; rs2629132; rs6442207; rs7618137; rs4525846; rs3821762; rs7650862; rs2272398; rs10049332; rs11708378; rs1580442; rs3774120; rs12497527; rs2629135; rs4684738; rs3774074; rs11128528; rs9844469; rs4684745; rs6791465; rs1807318; rs9855033; rs966030; rs7648448; rs2655284; rs7636799; rs11712487; rs755332; rs6442212; rs3821763; rs3774121; rs11720592; rs3774128; rs1601370; rs11710402; rs2304724; rs1601372; rs1609480; rs1881368; rs11706246; rs3774081; rs11719866; rs1843277; rs17033567; rs12634925; rs2581212; rs7617750; rs4602370; rs4684744; rs1485145; rs6785782; rs12493203; rs3821766; rs17033529; rs1872391; rs7649311; rs11929135; rs1809529; rs3774129; rs3774089; rs3774117; rs2629134; rs901026; rs7647698; rs2629122; rs13059801; rs3821764; rs13079153; rs1994261; rs4541387; rs9859040; rs11923141; rs17033548; rs11720695; rs715148; rs13081818; rs2062366; rs3774109; rs3774125; rs11919120; rs11918448; rs1817570; rs12330294; rs3821754; rs3774084; rs9829082; rs11926965; rs4684747; rs13319764; rs6803822; rs3774096; rs17033651; rs7620904; rs3836463; rs3774115; rs3821768; rs3774083; rs6779181; rs13097219; rs6807779; rs11716365; rs901032; rs3774082; rs3774107; rs999448; rs9845079; rs13062556; rs1485133; rs7629978; rs2581208; rs6775654; rs11925561; rs9861593; rs7628460; rs13078932; rs9860808; rs12637603; rs7631023; rs2581209; rs12397640; rs17033665; rs11927152; rs2600072; rs2581219; rs41308279; rs41308275; rs4536806; rs9846244; rs2923851; rs13086897; rs34223012; rs13086776; rs2601121; rs41304868; rs1807317; rs34769735; rs34770723; rs2928075; rs2655273; rs34767884; rs33980604; rs34527920; rs2629125; rs2077253; rs35626500; rs11924922; rs2272397; rs34084820; rs2938403; rs9811957; rs11927738; rs5846686; rs35060693; rs6770378; rs34534401; rs41293361; rs6789517; rs7623209; rs9851587; rs9848603; rs5846683; rs2950804; rs3732945; rs35692912; rs35381221; rs34616599; rs2581203; rs28595895; rs9821889; rs3836461; rs34251520; rs13070185; rs13082433; rs34661734; rs34263808; rs41308277; rs2581200; rs34134730; rs34707916; rs13086759; rs958470; rs35381777; rs2581214; rs34189890; rs6770380; rs3774093; rs35112270; rs34309032; rs36087056; rs7653062; rs750174; rs34883736; rs2272396; rs28516905; rs34455230; rs34797297; rs12495007; rs34129830; rs35032328; rs3821765; rs34230224; rs3774122; rs34982364; rs41293363; rs2655269; rs4373053; rs7622695; rs34966511; rs3836462; rs35260536; rs13086924; rs34979892; rs901030; rs28490351; rs2629124; rs35418313; rs35206654; rs35764986; rs9843447; rs34177340; rs4284961; rs4505681; rs34474776; rs11284997; rs2655270; rs6780274; rs35167441; rs35862046; rs35445550; rs2581201; rs7630744; rs17033580; rs35320455; rs34936417; rs2655271; rs6783225; rs28410774; rs11371916; rs10049075; rs34086036; rs35747056; rs34653825; rs2938402; rs2923849; rs34648959; rs35989736; rs2950805; rs34432844; rs35594707; rs12496495; rs28753873; rs750173; rs876645; rs35859776; rs1905756; rs5846681; rs34322038; rs9846118; rs36012755; rs35546613; rs9855154; rs3821759; rs34936845; rs2581213; rs10049203; rs28658050; rs2655275; rs34865770; rs2697157; rs3774103; rs9840941; rs13066552; rs13066373; rs3774111; rs7653444; rs13060065; rs35674840; rs4234505; rs35049900; rs34600807; rs6807787; rs41295968; rs1809528; rs4637272; rs11361230; rs35484118; rs2655272; rs6783303; rs36027556; rs3821756; rs9815640; rs41469944; rs5846682; rs3821760; rs2017848; rs9851830; rs1580443; rs7625514; rs1905757; rs12330244; rs2923850; rs34355508; rs2655285; rs35498692; rs3101847; rs34902243; rs34301698; rs2581202; rs35242172; rs1610181; rs34211865; rs13087062; rs2655276; rs35830689; rs6774668; rs3841959; rs34653582; rs1586260; rs3821758; rs28447061; rs34001214; rs35119727; rs901027; rs10618798; rs7617470; rs34705667; rs9825913; rs5024274; rs41315896; rs41295966; rs3836460; rs35942645; rs35387224; rs2928073; rs34577499; rs35285195; rs34447235; rs11128534; rs11705992; rs11719728; rs11916959; rs12491841; rs2141356; rs2171003; rs2292103; rs2601122; rs2629104; rs2629106; rs2655282; rs2655286; rs2655287; rs2655296; rs2655297; rs2655301; rs2697163; rs2933296; rs2938400; rs2938401; rs2950807; rs3732370; rs3732371; rs6782922; rs9815136

# Macromolecular_Interacting_Partner_21_General_References:
7874447

# Macromolecular_Interacting_Partner_21_References:
16466645; 16675519; 16766089

# Macromolecular_Interacting_Partner_22_ID:
7966

# Macromolecular_Interacting_Partner_22_Name:
Hypothetical protein GAD1

# Macromolecular_Interacting_Partner_22_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_22_Gene_Name:
GAD1

# Macromolecular_Interacting_Partner_22_Protein_Sequence:
>Hypothetical protein GAD1
MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEK
SRLVSAFKERQSSKNLLSCENSDRDARFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEV
VDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGV
RTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWS
SKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTSEQSHYSIKKAGAA
LGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDPIQEIA
DICEKYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKE
KGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQI
NKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAP
KIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL

# Macromolecular_Interacting_Partner_22_Number_of_Residues:
594

# Macromolecular_Interacting_Partner_22_Molecular_Weight:
66897

# Macromolecular_Interacting_Partner_22_Theoretical_pI:
7.67

# Macromolecular_Interacting_Partner_22_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_22_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_22_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_22_Pathway:
Not Available

# Macromolecular_Interacting_Partner_22_Reaction:
Not Available

# Macromolecular_Interacting_Partner_22_Pfam_Domain_Function:
PF00282:Pyridoxal_deC

# Macromolecular_Interacting_Partner_22_Signals:
None

# Macromolecular_Interacting_Partner_22_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_22_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_22_EC_Link:
EC 4.1.1.15

# Macromolecular_Interacting_Partner_22_GenBank_ID_Protein:
62988850

# Macromolecular_Interacting_Partner_22_SwissProt_ID:
Q53TQ7_HUMAN (Q53TQ7)

# Macromolecular_Interacting_Partner_22_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_22_Genecard_id:
GAD1

# Macromolecular_Interacting_Partner_22_Geneatlas_id:
GAD1

# Macromolecular_Interacting_Partner_22_hgnc_id:
HGNC:4092

# Macromolecular_Interacting_Partner_22_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_22_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_22_Gene_Sequence:
>1785 bp
ATGGCGTCTTCGACCCCATCTTCGTCCGCAACCTCCTCGAACGCGGGAGCGGACCCCAAT
ACCACTAACCTGCGCCCCACAACGTACGATACCTGGTGCGGCGTGGCCCATGGATGCACC
AGAAAACTGGGGCTCAAGATCTGCGGCTTCTTGCAAAGGACCAACAGCCTGGAAGAGAAG
AGTCGCCTTGTGAGTGCCTTCAAGGAGAGGCAATCCTCCAAGAACCTGCTTTCCTGTGAA
AACAGCGACCGGGATGCCCGCTTCCGGCGCACAGAGACTGACTTCTCTAATCTGTTTGCT
AGAGATCTGCTTCCGGCTAAGAACGGTGAGGAGCAAACCGTGCAATTCCTCCTGGAAGTG
GTGGACATACTCCTCAACTATGTCCGCAAGACATTTGATCGCTCCACCAAGGTGCTGGAC
TTTCATCACCCACACCAGTTGCTGGAAGGCATGGAGGGCTTCAACTTGGAGCTCTCTGAC
CACCCCGAGTCCCTGGAGCAGATCCTGGTTGACTGCAGAGACACCTTGAAGTATGGGGTT
CGCACAGGTCATCCTCGATTTTTCAACCAGCTCTCCACTGGATTGGATATTATTGGCCTA
GCTGGAGAATGGCTGACATCAACGGCCAATACCAACATGTTTACATATGAAATTGCACCA
GTGTTTGTCCTCATGGAACAAATAACACTTAAGAAGATGAGAGAGATAGTTGGATGGTCA
AGTAAAGATGGTGATGGGATATTTTCTCCTGGGGGCGCCATATCCAACATGTACAGCATC
ATGGCTGCTCGCTACAAGTACTTCCCGGAAGTTAAGACAAAGGGCATGGCGGCTGTGCCT
AAACTGGTCCTCTTCACCTCAGAACAGAGTCACTATTCCATAAAGAAAGCTGGGGCTGCA
CTTGGCTTTGGAACTGACAATGTGATTTTGATAAAGTGCAATGAAAGGGGGAAAATAATT
CCAGCTGATTTTGAGGCAAAAATTCTTGAAGCCAAACAGAAGGGATATGTTCCCTTTTAT
GTCAATGCAACTGCTGGCACGACTGTTTATGGAGCTTTTGATCCGATACAAGAGATTGCA
GATATATGTGAGAAATATAACCTTTGGTTGCATGTCGATGCTGCCTGGGGAGGTGGGCTG
CTCATGTCCAGGAAGCACCGCCATAAACTCAACGGCATAGAAAGGGCCAACTCAGTCACC
TGGAACCCTCACAAGATGATGGGCGTGCTGTTGCAGTGCTCTGCCATTCTCGTCAAGGAA
AAGGGTATACTCCAAGGATGCAACCAGATGTGTGCAGGATACCTCTTCCAGCCAGACAAG
CAGTATGATGTCTCCTACGACACCGGGGACAAGGCAATTCAGTGTGGCCGCCACGTGGAT
ATCTTCAAGTTCTGGCTGATGTGGAAAGCAAAGGGCACAGTGGGATTTGAAAACCAGATC
AACAAATGCCTGGAACTGGCTGAATACCTCTATGCCAAGATTAAAAACAGAGAAGAATTT
GAGATGGTTTTCAATGGCGAGCCTGAGCACACAAACGTCTGTTTTTGGTATATTCCACAA
AGCCTCAGGGGTGTGCCAGACAGCCCTCAACGACGGGAAAAGCTACACAAGGTGGCTCCA
AAAATCAAAGCCCTGATGATGGAGTCAGGTACGACCATGGTTGGCTACCAGCCCCAAGGG
GACAAGGCCAACTTCTTCCGGATGGTCATCTCCAACCCAGCCGCTACCCAGTCTGACATT
GACTTCCTCATTGAGGAGATAGAAAGACTGGGCCAGGATCTGTAA

# Macromolecular_Interacting_Partner_22_GenBank_ID_Gene:
AC007405

# Macromolecular_Interacting_Partner_22_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_22_Locus:
2q31

# Macromolecular_Interacting_Partner_22_SNPs:
rs769402; rs769403; rs41526346; rs769401; rs11542313; rs769395; rs2270335; rs769399; rs3749034; rs1049730; rs3762553; rs769406; rs769409; rs2058725; rs769391; rs769411; rs3791861; rs3791856; rs2270334; rs701492; rs4668331; rs3791857; rs769393; rs3791875; rs3791853; rs3791876; rs2302659; rs3791877; rs769390; rs3791862; rs10439259; rs2234728; rs4668329; rs2241164; rs3791860; rs7561581; rs3791850; rs6716794; rs3791865; rs3791858; rs2241165; rs3791851; rs7578661; rs3828275; rs6433253; rs16858977; rs3791866; rs16858988; rs6433252; rs3749033; rs34210682; rs12612498; rs769405; rs3791871; rs4668330; rs11900444; rs11896169; rs769408; rs3791874; rs3791859; rs4668327; rs41464547; rs41393845; rs1420385; rs1548902; rs41496949; rs1477061; rs11896015; rs701491; rs3791864; rs3791872; rs10930441; rs11890416; rs10191129; rs11895404; rs769407; rs3791855; rs2234727; rs11890409; rs3762556; rs3791878; rs6755370; rs3762557; rs3749035; rs3791879; rs6755371; rs3791880; rs2356236; rs3762554; rs4668324; rs872124; rs3762555; rs1049731; rs1049736; rs17857149; rs17857148; rs1049735; rs34856125; rs34100397; rs1049733; rs1049734; rs35426017; rs3049870; rs5836306; rs34510522; rs34365430; rs35367730; rs35542409; rs954947; rs17752543; rs13017667; rs35495756; rs3791868; rs10698625; rs3049892; rs11338558; rs11331088; rs41265947; rs3791852; rs13035478; rs769394; rs35089719; rs13018052; rs3838551; rs34072956; rs2160415; rs769389; rs34265473; rs13385854; rs2160414; rs11338557; rs34462898; rs13014614; rs35050499; rs3791867; rs4668332; rs13017665; rs3828274; rs35232338; rs34347776; rs13000989; rs35659093; rs4668325; rs10698618; rs34528852; rs3791873; rs7602684; rs12995992; rs35050304; rs6753612; rs35212610; rs10179059; rs35492651; rs3838552; rs7576933; rs41304175; rs34884445; rs10529529; rs13028093; rs35845895; rs41315874; rs28514878; rs3749032; rs3791854; rs35445717; rs769398; rs5836308; rs12991140; rs13014984; rs13033900; rs3791869; rs11333718; rs3791863; rs10605864; rs7594314; rs4667661; rs34291719; rs3791870; rs11314645; rs35495071; rs769410; rs4536622; rs10623405; rs35403424; rs4668326; rs3838550; rs10930442; rs3838553; rs35991368; rs4668328; rs13014595; rs7595288; rs11327360; rs35566565; rs35379843; rs41311313; rs5836305; rs1362492; rs4667659; rs3762558; rs4667660; rs6755102; rs6758358; rs33918896; rs34236419; rs10803852; rs10930443; rs11682957; rs11694200; rs11904485; rs12185692; rs12472230; rs12614879; rs12999141; rs13432752; rs16858996; rs17701824; rs1978340; rs2160413; rs2192987; rs28642888; rs3762560; rs3762561; rs4389303; rs4667662; rs4667663; rs6433254; rs6433255; rs6433256; rs6433257; rs6433261; rs6755814; rs7564761; rs7577421

# Macromolecular_Interacting_Partner_22_General_References:
Not Available

# Macromolecular_Interacting_Partner_22_References:
16420077; 16461938; 16516347; 16545783

# Macromolecular_Interacting_Partner_23_ID:
8259

# Macromolecular_Interacting_Partner_23_Name:
GRINL1A combined protein Gcom13 precursor

# Macromolecular_Interacting_Partner_23_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_23_Gene_Name:
GRINL1A

# Macromolecular_Interacting_Partner_23_Protein_Sequence:
>GRINL1A combined protein Gcom13 precursor
MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN
GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVSHAQQEYLENHIQ
TQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQR
QLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEET
NSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGEL
TDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQL
LEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPSQTGRTREIVMPSRNYT
PYTRVLELTMKKTLT

# Macromolecular_Interacting_Partner_23_Number_of_Residues:
435

# Macromolecular_Interacting_Partner_23_Molecular_Weight:
50382

# Macromolecular_Interacting_Partner_23_Theoretical_pI:
5.50

# Macromolecular_Interacting_Partner_23_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_23_General_Function:
Cell wall/membrane/envelope biogenesis 

# Macromolecular_Interacting_Partner_23_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_23_Pathway:
Not Available

# Macromolecular_Interacting_Partner_23_Reaction:
Not Available

# Macromolecular_Interacting_Partner_23_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_23_Signals:
1-16

# Macromolecular_Interacting_Partner_23_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_23_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_23_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_23_GenBank_ID_Protein:
34596313

# Macromolecular_Interacting_Partner_23_SwissProt_ID:
Q6EER8_HUMAN (Q6EER8)

# Macromolecular_Interacting_Partner_23_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_23_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_23_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_23_hgnc_id:
Not Available

# Macromolecular_Interacting_Partner_23_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_23_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_23_Gene_Sequence:
>1308 bp
ATGCTGCGCTCCACGTCCACGGTCACCCTGCTCTCGGGCGGCGCCGCCAGGACGCCCGGG
GCGCCCAGCAGGAGGGCAAATGTTTGCAGACTACGGCTGACCGTACCTCCTGAGAGTCCA
GTTCCTGAGCAATGTGAAAAGAAGATTGAGAGAAAAGAGCAGCTTCTTGACCTGAGCAAT
GGAGAACCTACCAGGAAACTTCCTCAGGGTGTTGTTTATGGTGTGGTGCGAAGATCAGAT
CAAAATCAGCAGAAAGAAATGGTGGTGTATGGGTGGTCCACCAGTCAGCTGAAAGAAGAG
ATGAACTACATCAAAGATGTTTCCCATGCTCAGCAGGAGTATCTGGAGAATCACATCCAA
ACCCAGTCGTCTGCCCTGGATCGTTTTAATGCCATGAACTCAGCCTTGGCATCAGATTCC
ATTGGCCTGCAAAAAACCCTCGTGGATGTGACTTTGGAAAACAGCAACATTAAGGATCAA
ATCAGAAATCTGCAGCAGACGTATGAAGCATCCATGGACAAGCTGAGGGAAAAGCAGAGG
CAGTTGGAGGTAGCGCAAGTTGAAAACCAGCTGCTAAAAATGAAGGTGGAATCGTCCCAA
GAAGCCAATGCTGAGGTGATGCGAGAGATGACCAAGAAGCTGTACAGCCAGTATGAGGAG
AAGCTGCAGGAAGAACAGAGGAAGCACAGTGCTGAGAAGGAGGCTCTTTTGGAAGAAACC
AATAGTTTTCTGAAAGCGATTGAAGAAGCCAATAAAAAGATGCAAGCAGCAGAGATCAGC
CTAGAGGAGAAAGACCAGAGGATCGGGGAGCTGGACAGGCTGATTGAGCGCATGGAAAAG
GAACGTCATCAACTGCAACTTCAACTCCTAGAACATGAAACAGAAATGTCTGGGGAGTTA
ACTGATTCTGACAAGGAAAGGTATCAGCAGTTGGAGGAGGCATCAGCCAGCCTCCGTGAG
CGGATCAGACACCTAGATGACATGGTGCATTGCCAGCAGAAGAAAGTCAAGCAGATGGTC
GAGGAGATTGAATCATTAAAGAAAAAGTTGCAACAGAAACAGCTCTTAATACTGCAGCTT
TTAGAAAAGATATCTTTCTTAGAAGGAGAGAATAATGAACTACAAAGCAGGTTGGACTAT
TTAACAGAAACCCAGGCCAAGACTGAAGTGGAAACCAGAGAGATAGGAGTGGGCTGTGAT
CTTCTACCCAGCCAAACAGGCAGGACTCGTGAAATTGTGATGCCTTCTAGGAACTACACC
CCATACACAAGAGTCCTGGAGTTAACCATGAAGAAAACTCTGACTTAG

# Macromolecular_Interacting_Partner_23_GenBank_ID_Gene:
AY353060

# Macromolecular_Interacting_Partner_23_Chromosome_Location:
Chromosome:15

# Macromolecular_Interacting_Partner_23_Locus:
15q22.1

# Macromolecular_Interacting_Partner_23_SNPs:
Not Available

# Macromolecular_Interacting_Partner_23_General_References:
Not Available

# Macromolecular_Interacting_Partner_23_References:
16420458; 17105908

# Macromolecular_Interacting_Partner_24_ID:
7981

# Macromolecular_Interacting_Partner_24_Name:
Solute carrier family 12 member 5

# Macromolecular_Interacting_Partner_24_Synonyms:
Electroneutral potassium-chloride cotransporter 2; Erythroid K-Cl cotransporter 2; Neuronal K-Cl cotransporter; hKCC2

# Macromolecular_Interacting_Partner_24_Gene_Name:
SLC12A5

# Macromolecular_Interacting_Partner_24_Protein_Sequence:
>Solute carrier family 12 member 5
MLNNLTDCEDGDGGANPGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSS
LLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRL
TWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAV
GLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTC
MATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFD
VCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWS
SYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNR
SGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLA
WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLL
TACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSF
LGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRL
EEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHP
QAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWR
QKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLML
LPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISA
YTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETA
GDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKG
PSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRN
RNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS

# Macromolecular_Interacting_Partner_24_Number_of_Residues:
1116

# Macromolecular_Interacting_Partner_24_Molecular_Weight:
123513

# Macromolecular_Interacting_Partner_24_Theoretical_pI:
6.22

# Macromolecular_Interacting_Partner_24_GO_Classification:
>>>
Function:  ion transporter activity
Function:  cation transporter activity
Function:  anion:cation symporter activity
Function:  cation:chloride symporter activity
Function:  transporter activity
 ||
>>>
Process:  anion transport
Process:  inorganic anion transport
Process:  chloride transport
Process:  cation transport
Process:  monovalent inorganic cation transport
Process:  sodium ion transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
 ||
>>>
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_24_General_Function:
Not Available

# Macromolecular_Interacting_Partner_24_Specific_Function:
Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons

# Macromolecular_Interacting_Partner_24_Pathway:
Not Available

# Macromolecular_Interacting_Partner_24_Reaction:
Not Available

# Macromolecular_Interacting_Partner_24_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_24_Signals:
None

# Macromolecular_Interacting_Partner_24_Transmembrane_Regions:
111-131
133-153
172-192
194-214
232-252
255-275
396-416
436-456
474-494
547-567
608-628
825-845

# Macromolecular_Interacting_Partner_24_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_24_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_24_GenBank_ID_Protein:
12003227

# Macromolecular_Interacting_Partner_24_SwissProt_ID:
S12A5_HUMAN (Q9H2X9)

# Macromolecular_Interacting_Partner_24_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_24_Genecard_id:
SLC12A5

# Macromolecular_Interacting_Partner_24_Geneatlas_id:
SLC12A5

# Macromolecular_Interacting_Partner_24_hgnc_id:
HGNC:13818

# Macromolecular_Interacting_Partner_24_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_24_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_24_Gene_Sequence:
>3351 bp
ATGCCCAACAACCTGACGGACTGCGAGGACGGCGATGGGGGAGCCAACCCGGGTGATGGC
AACCCCAAGGAAAGCAGTCCCTTCATCAACAGCACCGACACAGAGAAGGGAAAGGAGTAT
GATGGCAAGAACATGGCCTTGTTTGAGGAGGAGATGGACACCAGCCCTATGGTGTCCTCC
TTGCTCAGTGGCCTGGCCAACTACACCAACCTGCCCCAGGGAAGTAGGGAGCATGAAGAG
GCAGAAAACAATGAGGGTGGAAAAAAGAAGCCGGTGCAGGCCCCACGCATGGGCACCTTC
ATGGGCGTGTACCTGCCGTGCCTGCAGAACATCTTTGGCGTCATCCTCTTCCTGCGGCTC
ACCTGGGTGGTGGGCATTGCAGGCATCATGGAGTCCTTCTGCATGGTGTTCATCTGCTGC
TCCTGTACGATGCTCACGGCCATCTCCATGAGTGCAATTGCAACGAATGGTGTTGTGCCT
GCTGGTGGCTCCTACTACATGATTTCCAGGTCTCTGGGCCCAGAGTTTGGGGGTGCCGTG
GGCCTCTGCTTCTACCTGGGCACTACCTTTGCAGGAGCCATGTACATCCTGGGCACCATC
GAAATCCTGCTGGCTTACCTCTTCCCAGCCATGGCCATCTTCAAGGCAGAAGATGCCAGT
GGGGAGGCAGCAGCCATGCTGAACAACATGCGTGTTTACGGCACCTGTGTGCTCACCTGC
ATGGCCACTGTGGTGTTTGTGGGTGTCAAGTATGTCAACAAGTTTGCCCTTGTCTTCCTG
GGTTGTGTCATCCTCTCCATCCTGGCCATCTATGCTGGGGTCATCAAGTCTGCCTTCGAC
CCACCCAACTTCCCGATCTGCCTCCTGGGTAACCGCACGCTGTCTCGCCATGGCTTTGAT
GTCTGTGCCAAGCTGGCTTGGGAAGGAAATGAGACGGTGACCACACGGCTATGGGGCCTT
TTCTGCTCCTCTCGCTTCCTCAACGCCACCTGTGATGAATACTTCACCCGAAACAATGTC
ACAGAGATCCAGGGCATCCCTGGTGCTGCCAGTGGCCTCATCAAAGAGAACCTCTGGAGC
TCCTACCTGACCAAGGGCGTGATTGTGGAGAGGAGTGGGATGACCTCGGTGGGCCTGGCC
GATGGCACTCCTATCGACATGGACCACCCTTATGTCTTCAGTGATATGACCTCCTACTTC
ACCCTGCTGGTTGGCATCTACTTCCCCTCAGTCACAGGGATCATGGCTGGTTCTAACCGC
TCTGGGGACCTGAGGGATGCCCAGAAGTCAATCCCCACTGGCACCATCCTGGCCATCGCC
ACCACCTCTGCTGTCTACATCAGCTCCGTTGTTCTGTTTGGGGCCTGCATTGAGGGGGTC
GTCCTGCGGGACAAGTTTGGCGAAGCTGTGAATGGCAACCTCGTGGTGGGCACTCTGGCC
TGGCCATCTCCATGGGTAATTGTCATCGGATCCTTCTTCTCCACCTGTGGGGCTGGGCTG
CAGAGCCTCACGGGGGCCCCACGCCTGCTGCAGGCCATCTCGAGGGATGGCATTGTGCCC
TTCCTGCAGGTCTTTGGCCATGGCAAGGCCAATGGAGAGCCGACCTGGGCCCTGCTCCTG
ACTGCCTGCATCTGCGAGATTGGCATCCTCATTGCATCCCTCGACGAGGTGGCCCCCATC
CTCTCTATGTTCTTCCTGATGTGCTACATGTTTGTGAATCTGGCCTGTGCAGTGCAGACG
CTGCTGAGGACACCCAACTGGAGGCCACGCTTTCGATATTACCACTGGACCCTCTCCTTC
CTGGGCATGAGCCTCTGCCTGGCCCTCATGTTCATCTGCTCCTGGTATTATGCACTGGTA
GCCATGCTCATTGCTGGACTCATCTACAAGTACATTGAGTACCGTGGGGCAGAGAAGGAG
TGGGGCGATGGGATACGAGGTCTGTCTCTCAGTGCGGCTCGCTATGCCCTCTTACGCCTG
GAGGAAGGGCCCCCACACACCAAGAACTGGAGGCCACAGCTGCTGGTGCTGGTGCGTGTG
GACCAAGACCAGAATGTGGTGCACCCCCAGCTGCTCTCACTGACCTCCCAGCTGAAGGCA
GGGAAGGGCCTGACCATCGTGGGCTCTGTCCTTGAGGGCACCTTTCTGGAAAATCATCCA
CAGGCCCAGCGGGCAGAAGAGTCTATCAGGCGCCTGATGGAGGCAGAGAAGGTGAAGGGC
TTCTGCCAGGTGGTGATCTCCTCCAACTTGCGTGATGGCGTGTCCCATCTGATCCAGTCC
GGGGGCCTCGGGGGGCTGCAGCACAACACTGTGCTTGTTGGCTGGCCCCGCAACTGGCGC
CAGAAGGAAGATCATCAGACGTGGAGGAACTTCATTGAGCTGGTCCGGGAAACCACAGCT
GGCCACTTAGCCCTGCTGGTCACCAAGAACGTTTCCATGTTTCCTGGGAACCCTGAGCGC
TTCTCTGAGGGCAGCATCGACGTTTGGTGGATTGTGCACGATGGAGGCATGCTCATGCTG
CTGCCCTTCCTGCTGCGGCACCACAAGGTCTGGCGGAAGTGCAAGATGCGTATCTTCACT
GTGGCCCAGATGGATGACAATAGCATCCAGATGAAGAAGGATCTGACCACATTTCTGTAT
CATTTACGCATCACTGCGGAGGTCGAGGTGGTGGAGATGCATGAGAGCGACATCTCAGCT
TACACCTATGAGAAGACGTTGGTGATGGAGCAGCGTTCCCAGATCCTCAAACAGATGCAT
TTAACCAAGAATGAGCGGGAGCGGGAGATCCAGAGTATCACAGATGAGTCACGAGGCTCA
ATCCGGAGAAAGAATCCAGCCAACACGCGGCTCCGCCTGAACGTCCCAGAAGAGACGGCT
GGTGACAGTGAAGAGAAGCCAGAGGAGGAGGTGCAGCTGATCCACGATCAGAGTGCTCCC
AGCTGCCCCAGCAGCTCCCCGTCCCCAGGGGAGGAGCCTGAGGGGGAAGGGGAGACAGAT
CCGGAGAAGGTGCATCTCACCTGGACCAAGGACAAGTCGGTGGCAGAGAAGAATAAGGGC
CCCAGTCCTGTCTCCTCTGAGGGCATCAAGGACTTCTTCAGCATGAAGCCGGAGTGGGAG
AACTTGAACCAGTCCAACGTGCGGCGCATGCACACGGCCGTGCGGCTGAACGAGGTCATC
GTGAAGAAATCCCGGGACGCCAAGCTTGTTTTGCTCAACATGCCTGGGCCTCCCCGCAAC
CGCAATGGTGATGAAAACTACATGGAGTTTCTCGAGGTCCTCACAGAGCACCTGGACCGG
GTGATGCTGGTCCGCGGTGGTGGCCGAGAGGTCATCACCATCTACTCCTGA

# Macromolecular_Interacting_Partner_24_GenBank_ID_Gene:
AF208159

# Macromolecular_Interacting_Partner_24_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_24_Locus:
20q13.12

# Macromolecular_Interacting_Partner_24_SNPs:
rs16985442; rs17297532; rs3848724; rs3746522; rs3746519; rs35804246; rs3746521; rs17344810; rs1128536; rs9074; rs7266662; rs6065917; rs2297199; rs4812985; rs12481488; rs2297197; rs3746516; rs3859613; rs3848727; rs3746515; rs2297198; rs4812987; rs6104433; rs12479662; rs3848723; rs16991026; rs2297200; rs6073993; rs12480942; rs2903810; rs16985435; rs2297201; rs3848725; rs2868364; rs3746518; rs6017731; rs3901163; rs4812986; rs12624433; rs6073995; rs12480008; rs11696784; rs11699335; rs6032637; rs3746517; rs4810483; rs4812988; rs3737064; rs6032629; rs3848726; rs3746520; rs12480918; rs6094240; rs6104437; rs11906568; rs16991024; rs6131001; rs6032638; rs6032631; rs11699481; rs6032627; rs6032636; rs8125780; rs6124764; rs6073991; rs11908352; rs34058554; rs6074002; rs6073997; rs35981087; rs10460627; rs6094245; rs41282782; rs41282784; rs6065914; rs6131007; rs6032640; rs2664528; rs6065916; rs6065915; rs6104446; rs34116575; rs16989622; rs6094246; rs11470685; rs7274705; rs6032641; rs35959757; rs6094244; rs35439936; rs6017732; rs6104438; rs28696773; rs12625509; rs8115080; rs34688239; rs6131002; rs6073998; rs2297196; rs6032634; rs11405083; rs6094243; rs6104435; rs6073994; rs6032630; rs3848728; rs2868365; rs35505185; rs35045805; rs6104440; rs6032633; rs7346296; rs11483199; rs12373874; rs6104443; rs34974085; rs35301601; rs34669030; rs6104434; rs13039389; rs11700228; rs7272980; rs34618340; rs12625089; rs11470072; rs6032639; rs11477872; rs34834975; rs6074000; rs16985440; rs11905317; rs12479764; rs6131005; rs33941278; rs34076479; rs13041935; rs6104441; rs11700043; rs3080279; rs35432045; rs6032632; rs6104445; rs11460894; rs3746514; rs6017730; rs11375367; rs33990605; rs35720358; rs6074001; rs6124765; rs35310239; rs35046648; rs6131003; rs6073999; rs11481017; rs6104436; rs35611652; rs4126368; rs6104439; rs34584025; rs13039932; rs6094241; rs35422720; rs33942190; rs6131004; rs6017729; rs6104444; rs11478722; rs35754569; rs35829181; rs34537865; rs13039939; rs6094242; rs11696488; rs34660043; rs35034253; rs35377254; rs6017727; rs6073992; rs6032642; rs11470662; rs11086993; rs35303427; rs35175715; rs6131000; rs34690878; rs34146059; rs11700057; rs12480479; rs12480874; rs13037326; rs1537028; rs15949; rs16991048; rs17450969; rs2425750; rs2664549; rs2903908; rs3092502; rs34503366; rs35315891; rs35481630; rs3746523; rs4812989; rs6032625; rs6032635; rs6032645; rs6032646; rs6032647; rs6073990; rs6074006; rs6074007; rs6074008; rs6074009; rs6094247; rs6104432; rs6104449; rs6104450; rs6130998; rs6130999

# Macromolecular_Interacting_Partner_24_General_References:
12106695; 11780052; 10574461

# Macromolecular_Interacting_Partner_24_References:
16420452; 16936706; 16943550; 17045484

# Macromolecular_Interacting_Partner_25_ID:
7818

# Macromolecular_Interacting_Partner_25_Name:
Gamma-aminobutyric acid type B receptor, subunit 1 precursor

# Macromolecular_Interacting_Partner_25_Synonyms:
GABA-B receptor 1; GABA-B-R1; Gb1

# Macromolecular_Interacting_Partner_25_Gene_Name:
GABBR1

# Macromolecular_Interacting_Partner_25_Protein_Sequence:
>Gammaaminobutyric acid type B receptor, subunit 1 precursor
MLLLLLLAPLFLRPPGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVD
YEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLP
ALDGARVDFRCDPDFHLVGSSRSICSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSG
GWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKI
ILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKL
FEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDAR
IIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVE
GHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALA
LNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIE
QLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSS
LGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFP
FVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGM
DVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLL
LLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLA
IVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEK
IIAEKEERVSELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDRLSCDGSRVHLLY
K

# Macromolecular_Interacting_Partner_25_Number_of_Residues:
961

# Macromolecular_Interacting_Partner_25_Molecular_Weight:
108321

# Macromolecular_Interacting_Partner_25_Theoretical_pI:
8.30

# Macromolecular_Interacting_Partner_25_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  metabotropic glutamate, GABA-B-like receptor activity
Function:  GABA-B receptor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_25_General_Function:
Not Available

# Macromolecular_Interacting_Partner_25_Specific_Function:
Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites

# Macromolecular_Interacting_Partner_25_Pathway:
Not Available

# Macromolecular_Interacting_Partner_25_Reaction:
Not Available

# Macromolecular_Interacting_Partner_25_Pfam_Domain_Function:
PF00003:7tm_3;
PF01094:ANF_receptor;
PF00084:Sushi

# Macromolecular_Interacting_Partner_25_Signals:
1-14

# Macromolecular_Interacting_Partner_25_Transmembrane_Regions:
592-612
632-652
668-688
711-731
769-789
805-825
834-854

# Macromolecular_Interacting_Partner_25_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_25_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_25_GenBank_ID_Protein:
3892594

# Macromolecular_Interacting_Partner_25_SwissProt_ID:
GABR1_HUMAN (Q9UBS5)

# Macromolecular_Interacting_Partner_25_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_25_Genecard_id:
GABBR1

# Macromolecular_Interacting_Partner_25_Geneatlas_id:
GABBR1

# Macromolecular_Interacting_Partner_25_hgnc_id:
HGNC:4070

# Macromolecular_Interacting_Partner_25_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_25_Subcellular_Location:
Cell membrane; multi-pass membrane protein. Isoform 1E:Secreted protein (Probable). Note=Colocalizes with ATF4 in hippocampal neuron dendritic membranes. Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane

# Macromolecular_Interacting_Partner_25_Gene_Sequence:
>2886 bp
ATGTTGCTGCTGCTGTTACTGGCGCCACTCTTCCTCCGCCCCCCGGGCGCGGGCGGGGCG
CAGACCCCCAACGCCACCTCAGAAGGTTGCCAGATCATACACCCGCCCTGGGAAGGGGGC
ATCAGGTACCGGGGCCTGACTCGGGACCAGGTGAAGGCTATCAACTTCCTGCCAGTGGAC
TATGAGATTGAGTATGTGTGCCGGGGGGAGCGCGAGGTGGTGGGGCCCAAGGTCCGCAAG
TGCCTGGCCAACGGCTCCTGGACAGATATGGACACACCCAGCCGCTGTGTCCGAATCTGC
TCCAAGTCTTATTTGACCCTGGAAAATGGGAAGGTTTTCCTGACGGGTGGGGACCTCCCA
GCTCTGGACGGAGCCCGGGTGGATTTCCGGTGTGACCCCGACTTCCATCTGGTGGGCAGC
TCCCGGAGCATCTGTAGTCAGGGCCAGTGGAGCACCCCCAAGCCCCACTGCCAGGTGAAT
CGAACGCCACACTCAGAACGGCGCGCAGTGTACATCGGGGCACTGTTTCCCATGAGCGGG
GGCTGGCCAGGGGGCCAGGCCTGCCAGCCCGCGGTGGAGATGGCGCTGGAGGACGTGAAT
AGCCGCAGGGACATCCTGCCGGACTATGAGCTCAAGCTCATCCACCACGACAGCAAGTGT
GATCCAGGCCAAGCCACCAAGTACCTATATGAGCTGCTCTACAACGACCCTATCAAGATC
ATCCTTATGCCTGGCTGCAGCTCTGTCTCCACGCTGGTGGCTGAGGCTGCTAGGATGTGG
AACCTCATTGTGCTTTCCTATGGCTCCAGCTCACCAGCCCTGTCAAACCGGCAGCGTTTC
CCCACTTTCTTCCGAACGCACCCATCAGCCACACTCCACAACCCTACCCGCGTGAAACTC
TTTGAAAAGTGGGGCTGGAAGAAGATTGCTACCATCCAGCAGACCACTGAGGTCTTCACT
TCGACTCTGGACGACCTGGAGGAACGAGTGAAGGAGGCTGGAATTGAGATTACTTTCCGC
CAGAGTTTCTTCTCAGATCCAGCTGTGCCCGTCAAAAACCTGAAGCGCCAGGATGCCCGA
ATCATCGTGGGACTTTTCTATGAGACTGAAGCCCGGAAAGTTTTTTGTGAGGTGTACAAG
GAGCGTCTCTTTGGGAAGAAGTACGTCTGGTTCCTCATTGGGTGGTATGCTGACAATTGG
TTCAAGATCTACGACCCTTCTATCAACTGCACAGTGGATGAGATGACTGAGGCGGTGGAG
GGCCACATCACAACTGAGATTGTCATGCTGAATCCTGCCAATACCCGCAGCATTTCCAAC
ATGACATCCCAGGAATTTGTGGAGAAACTAACCAAGCGACTGAAAAGACACCCTGAGGAG
ACAGGAGGCTTCCAGGAGGCACCGCTGGCCTATGATGCCATCTGGGCCTTGGCACTGGCC
CTGAACAAGACATCTGGAGGAGGCGGCCGTTCTGGTGTGCGCCTGGAGGACTTCAACTAC
AACAACCAGACCATTACCGACCAAATCTACCGGGCAATGAACTCTTCGTCCTTTGAGGGT
GTCTCTGGCCATGTGGTGTTTGATGCCAGCGGCTCTCGGATGGCATGGACGCTTATCGAG
CAGCTTCAGGGTGGCAGCTACAAGAAGATTGGCTACTATGACAGCACCAAGGATGATCTT
TCCTGGTCCAAAACAGATAAATGGATTGGAGGGTCCCCCCCAGCTGACCAGACCCTGGTC
ATCAAGACATTCCGCTTCCTGTCACAGAAACTCTTTATCTCCGTCTCAGTTCTCTCCAGC
CTGGGCATTGTCCTAGCTGTTGTCTGTCTGTCCTTTAACATCTACAACTCACATGTCCGT
TATATCCAGAACTCACAGCCCAACCTGAACAACCTGACTGCTGTGGGCTGCTCACTGGCT
TTAGCTGCTGTCTTCCCCCTGGGGCTCGATGGTTACCACATTGGGAGGAACCAGTTTCCT
TTCGTCTGCCAGGCCCGCCTCTGGCTCCTGGGCCTGGGCTTTAGTCTGGGCTACGGTTCC
ATGTTCACCAAGATTTGGTGGGTCCACACGGTCTTCACAAAGAAGGAAGAAAAGAAGGAG
TGGAGGAAGACTCTGGAACCCTGGAAGCTGTATGCCACAGTGGGCCTGCTGGTGGGCATG
GATGTCCTCACTCTCGCCATCTGGCAGATCGTGGACCCTCTGCACCGGACCATTGAGACA
TTTGCCAAGGAGGAACCTAAGGAAGATATTGACGTCTCTATTCTGCCCCAGCTGGAGCAT
TGCAGCTCCAGGAAGATGAATACATGGCTTGGCATTTTCTATGGTTACAAGGGGCTGCTG
CTGCTGCTGGGAATCTTCCTTGCTTATGAGACCAAGAGTGTGTCCACTGAGAAGATCAAT
GATCACCGGGCTGTGGGCATGGCTATCTACAATGTGGCAGTCCTGTGCCTCATCACTGCT
CCTGTCACCATGATTCTGTCCAGCCAGCAGGATGCAGCCTTTGCCTTTGCCTCTCTTGCC
ATAGTTTTCTCCTCCTATATCACTCTTGTTGTGCTCTTTGTGCCCAAGATGCGCAGGCTG
ATCACCCGAGGGGAATGGCAGTCGGAGGCGCAGGACACCATGAAGACAGGGTCATCGACC
AACAACAACGAGGAGGAGAAGTCCCGGCTGTTGGAGAAGGAGAACCGTGAACTGGAAAAG
ATCATTGCTGAGAAAGAGGAGCGTGTCTCTGAACTGCGCCATCAACTCCAGTCTCGGCAG
CAGCTCCGCTCCCGGCGCCACCCACCGACACCCCCAGAACCCTCTGGGGGCCTGCCCAGG
GGACCCCCTGAGCCCCCCGACCGGCTTAGCTGTGATGGGAGTCGAGTGCATTTGCTTTAT
AAGTGA

# Macromolecular_Interacting_Partner_25_GenBank_ID_Gene:
AJ225028

# Macromolecular_Interacting_Partner_25_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_25_Locus:
6p21.31

# Macromolecular_Interacting_Partner_25_SNPs:
Not Available

# Macromolecular_Interacting_Partner_25_General_References:
9844003; 9872316; 9753614; 9798068; 9933300; 9889352; 10906333; 14574404; 10773016; 9872744; 10402495

# Macromolecular_Interacting_Partner_25_References:
16420458; 16516868; 16538684; 16620752

# Macromolecular_Interacting_Partner_26_ID:
8518

# Macromolecular_Interacting_Partner_26_Name:
Proton-coupled amino acid transporter 1

# Macromolecular_Interacting_Partner_26_Synonyms:
Proton/amino acid transporter 1; Solute carrier family 36 member 1

# Macromolecular_Interacting_Partner_26_Gene_Name:
SLC36A1

# Macromolecular_Interacting_Partner_26_Protein_Sequence:
>Protoncoupled amino acid transporter 1
MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNSTTWFQTLIHLLKGN
IGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCAHHFCRRLNKSFVDYGDTV
MYGLESSPCSWLRNHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQVIEAANGTTNNC
HNNETVILTPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIV
QRIPDPSHLPLVAPWKTYPLFFGTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVT
ILYISLGCLGYLQFGANIQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIP
FFVSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLE
VTTFYSEGMSPLTIFKDALISILGFVGFVVGTYEALYELIQPSNAPIFINSTCAFI

# Macromolecular_Interacting_Partner_26_Number_of_Residues:
476

# Macromolecular_Interacting_Partner_26_Molecular_Weight:
53076

# Macromolecular_Interacting_Partner_26_Theoretical_pI:
7.00

# Macromolecular_Interacting_Partner_26_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_26_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_26_Specific_Function:
Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid

# Macromolecular_Interacting_Partner_26_Pathway:
Not Available

# Macromolecular_Interacting_Partner_26_Reaction:
Not Available

# Macromolecular_Interacting_Partner_26_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_26_Signals:
1-216

# Macromolecular_Interacting_Partner_26_Transmembrane_Regions:
52-72
79-99
142-162
191-211
216-236
258-278
290-310
343-363
373-393
398-418
440-460

# Macromolecular_Interacting_Partner_26_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_26_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_26_GenBank_ID_Protein:
31324239

# Macromolecular_Interacting_Partner_26_SwissProt_ID:
S36A1_HUMAN (Q7Z2H8)

# Macromolecular_Interacting_Partner_26_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_26_Genecard_id:
SLC36A1

# Macromolecular_Interacting_Partner_26_Geneatlas_id:
SLC36A1

# Macromolecular_Interacting_Partner_26_hgnc_id:
HGNC:18761

# Macromolecular_Interacting_Partner_26_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_26_Subcellular_Location:
Cell membrane; multi-pass membrane protein. Lysosome; lysosomal membrane; multi-pass membrane protein (By similarity)

# Macromolecular_Interacting_Partner_26_Gene_Sequence:
>1431 bp
ATGTCCACGCAGAGACTTCGGAATGAAGACTACCACGACTACAGCTCCACGGACGTGAGC
CCTGAGGAGAGCCCGTCGGAAGGCCTCAACAACCTCTCCTCCCCGGGCTCCTACCAGCGC
TTTGGTCAAAGCAATAGCACAACATGGTTCCAGACCTTGATCCACCTGTTAAAAGGCAAC
ATTGGCACAGGACTCCTGGGACTCCCTCTGGCGGTGAAAAATGCAGGCATCGTGATGGGT
CCCATCAGCCTGCTGATCATAGGCATCGTGGCCGTGCACTGCATGGGTATCCTGGTGAAA
TGTGCTCACCACTTCTGCCGCAGGCTGAATAAATCCTTTGTGGATTATGGTGATACTGTG
ATGTATGGACTAGAATCCAGCCCCTGCTCCTGGCTCCGGAACCACGCACACTGGGGAAGA
CGTGTTGTGGACTTCTTCCTGATTGTCACCCAGCTGGGATTCTGCTGTGTCTATTTTGTG
TTTCTGGCTGACAACTTTAAACAGGTGATAGAAGCGGCCAATGGGACCACCAATAACTGC
CACAACAATGAGACGGTGATTCTGACGCCTACCATGGACTCGCGACTCTACATGCTCTCC
TTCCTGCCCTTCCTGGTGCTGCTGGTTTTCATCAGGAACCTCCGAGCCCTGTCCATCTTC
TCCCTGTTGGCCAACATCACCATGCTGGTCAGCTTGGTCATGATCTACCAGTTCATTGTT
CAGAGGATCCCAGACCCCAGCCACCTCCCCTTGGTGGCCCCTTGGAAGACCTACCCTCTC
TTCTTTGGCACAGCGATTTTTTCATTTGAAGGCATTGGAATGGTTCTGCCCCTGGAAAAC
AAAATGAAGGATCCTCGGAAGTTCCCACTCATCCTGTACCTGGGCATGGTCATCGTCACC
ATCCTCTACATCAGCCTGGGGTGTCTGGGGTACCTGCAATTTGGAGCTAATATCCAAGGC
AGCATAACCCTCAACCTGCCCAACTGCTGGTTGTACCAGTCAGTTAAGCTGCTGTACTCC
ATCGGGATCTTTTTCACCTACGCACTCCAGTTCTACGTCCCGGCTGAGATCATCATCCCC
TTCTTTGTGTCCCGAGCGCCCGAGCACTGTGAGTTAGTGGTGGACCTGTTTGTGCGCACA
GTGCTGGTCTGCCTGACATGCATCTTGGCCATCCTCATCCTCCGCCTGGACCTGGTCATC
TCCCTGGTGGGCTCCGTGAGCAGCAGCGCCCTGGCCCTCATCATCCCACCGCTCCTGGAG
GTCACCACCTTCTACTCAGAGGGCATGAGCCCCCTCACCATCTTTAAGGACGCCCTGATC
AGCATCCTGGGCTTCGGGGGCTTTGGGGGGGGGACCTATGAGGCTCTCTATGAGCTGATC
CAGCCAAGCAATGCTCCCATCTTCATCAATTCCACCTGTGCCTTCATATAG

# Macromolecular_Interacting_Partner_26_GenBank_ID_Gene:
AF516142

# Macromolecular_Interacting_Partner_26_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_26_Locus:
5q33.1

# Macromolecular_Interacting_Partner_26_SNPs:
rs9687945; rs918421; rs6871593; rs12655145; rs7706041; rs723329; rs165370; rs6875844; rs729057; rs4958272; rs4958458; rs1175; rs7730595; rs17112008; rs165323; rs165369; rs6872051; rs17740674; rs11954054; rs10077304; rs14160; rs17802828; rs17717168; rs12654623; rs2278372; rs6868032; rs2278373; rs35060330; rs13362472; rs11950575; rs10074670; rs165353; rs165366; rs357620; rs165364; rs357616; rs2271215; rs152722; rs415426; rs165359; rs357618; rs165350; rs357619; rs165363; rs357628; rs357610; rs165352; rs165367; rs357617; rs7700762; rs165351; rs6892322; rs357627; rs165355; rs7729973; rs357624; rs6579877; rs357614; rs152392; rs7730542; rs357629; rs165365; rs357623; rs357611; rs357613; rs152391; rs357622; rs165357; rs7721225; rs11949709; rs357625; rs17112022; rs7715996; rs173349; rs357608; rs2271217; rs152390; rs152389; rs165358; rs165356; rs6891599; rs441652; rs13165298; rs165361; rs165354; rs7722725; rs151755; rs12109083; rs12108809; rs10476986; rs17112026; rs12652584; rs193299; rs12517705; rs17740853; rs181548; rs357621; rs2278374; rs357609; rs13177627; rs394736; rs165360; rs357630; rs357612; rs189615; rs6884262; rs165324; rs10067717; rs3905908; rs10060512; rs35204299; rs34807130; rs36112231; rs34668619; rs34075182; rs34478431; rs165368; rs35191954; rs1238148; rs3832373; rs34023473; rs1876621; rs33959674; rs6865892; rs35523611; rs13436718; rs10054849; rs1494538; rs36036885; rs10635760; rs10076469; rs35240570; rs35074529; rs33931867; rs5872207; rs35097474; rs7710891; rs11553685; rs34867392; rs400501; rs34306317; rs1494537; rs6868168; rs1644031; rs11435061; rs35256722; rs34814099; rs13155218; rs190360; rs34768974; rs34046389; rs34232698; rs35595732; rs10050844; rs6878589; rs28703169; rs35929969; rs11389317; rs35868592; rs13172953; rs11453209; rs35002039; rs165362; rs28625753; rs6860029; rs13355111; rs34928684; rs35727313; rs34320512; rs36220874; rs5872208; rs1047371; rs33918956; rs357626; rs10067276; rs11750448; rs1654089; rs6878344; rs3841626; rs36024368; rs34013133; rs28591205; rs11949963; rs11167548; rs35707638; rs35655674; rs11303709; rs34145742; rs35361647; rs33938062; rs187180; rs7729206; rs11427460; rs10067553; rs6869796; rs34114557; rs13164973; rs3830456; rs34920684; rs35854261; rs11281205; rs2271216; rs33974809; rs3086279; rs34249564; rs10648851; rs12332278; rs35901406; rs35132795; rs36039116; rs28400419; rs34757222; rs34517564; rs35461038; rs10637454; rs11279332; rs2278375; rs35783925; rs13359993; rs34965236; rs6875491; rs35220703; rs35474478; rs13357451; rs34688075; rs6860591; rs12109979; rs36232311; rs11459545; rs35330119; rs10042192; rs10664114; rs10709981; rs11959634; rs28557209; rs10079386; rs6877865; rs35791981; rs10040628; rs10042791; rs10043854; rs10054626; rs10075373; rs10476771; rs11951808; rs11956563; rs13180182; rs165325; rs165326; rs165327; rs165328; rs165329; rs165330; rs165331; rs165332; rs165333; rs165334; rs165335; rs1654090; rs17111998; rs17717506; rs17802804; rs1876620; rs2545666; rs34831908; rs357607; rs385255; rs393824; rs420486; rs4958457; rs6579878; rs6879238; rs6885230; rs7356707; rs7714380; rs9324696

# Macromolecular_Interacting_Partner_26_General_References:
12809675

# Macromolecular_Interacting_Partner_26_References:
Not Available

# Macromolecular_Interacting_Partner_27_ID:
8669

# Macromolecular_Interacting_Partner_27_Name:
Sodium- and chloride-dependent GABA transporter 2

# Macromolecular_Interacting_Partner_27_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_27_Gene_Name:
SLC6A13

# Macromolecular_Interacting_Partner_27_Protein_Sequence:
>Sodium and chloridedependent GABA transporter 2
MDSRVSGTTSNGETKPVYHKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFL
FTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALF
YLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGI
QHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGA
AQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYSGTSFVA
GFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGL
DSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFPVGLIMLTEGGMYVFQLFDY
YAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATF
LFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSWSAFLPGASTDSEPSRAPSERESVSSC
AQPRTCPSGTQQDPRLPPPPGPHCSDSQS

# Macromolecular_Interacting_Partner_27_Number_of_Residues:
569

# Macromolecular_Interacting_Partner_27_Molecular_Weight:
63748

# Macromolecular_Interacting_Partner_27_Theoretical_pI:
6.79

# Macromolecular_Interacting_Partner_27_GO_Classification:
>>>
 Function:  transporter activity
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_27_General_Function:
Not Available

# Macromolecular_Interacting_Partner_27_Specific_Function:
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals

# Macromolecular_Interacting_Partner_27_Pathway:
Not Available

# Macromolecular_Interacting_Partner_27_Reaction:
Not Available

# Macromolecular_Interacting_Partner_27_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_27_Signals:
1-478

# Macromolecular_Interacting_Partner_27_Transmembrane_Regions:
23-43
51-70
95-115
188-206
215-232
268-285
293-308
341-360
390-408
425-445
466-485
505-523

# Macromolecular_Interacting_Partner_27_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_27_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_27_GenBank_ID_Protein:
7579920

# Macromolecular_Interacting_Partner_27_SwissProt_ID:
S6A13_HUMAN (Q9NSD5)

# Macromolecular_Interacting_Partner_27_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_27_Genecard_id:
SLC6A13

# Macromolecular_Interacting_Partner_27_Geneatlas_id:
SLC6A13

# Macromolecular_Interacting_Partner_27_hgnc_id:
HGNC:11046

# Macromolecular_Interacting_Partner_27_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_27_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_27_Gene_Sequence:
>1710 bp
ATGGATAGCAGGGTCTCAGGCACAACCAGTAATGGAGAGACAAAACCANTGTATCACAAG
ATGGAGTTTGTGCTGTCAGTGGCTGGGGAGATCATTGGCTTAGGCAACGTCTGGAGGTTT
CCCTATCTCTGCTACAAAAATGGGGGAGGTGCCTTCTTCATCCCCTACCTCGTCTTCCTC
TTTACCTGTGGCATTCCTGTCTTCCTTCTGGAGACAGCACTAGGCCAGTACACTAGCCAG
GGAGGCGTCACAGCCTGGAGGAAGATCTGCCCCATCTTTGAGGGCATTGGCTATGCCTCC
CAGATGATCGTCATCCTCCTCAACGTCTACTACATCATTGTGTTGGCCTGGGCCCTGTTC
TACCTCTTCAGCAGCTTCACCATCGACCTGCCCTGGGGCGGCTGCTACCATGAGTGGAAC
ACAGAACACTGTATGGAGTTCCAGAAGACCAACGGCTCCCTGAATGGTACCTCTGAGAAT
GCCACCTCTCCTGTCATCGAGTTCTGGGAGCGGCGGGTCTTGAAGATCTCTGATGGGATC
CAGCACCTGGGGGCCCTGCGCTGGGAGCTGGCTCTGTGCCTCCTGCTGGCCTGGGTCATC
TGCTACTTCTGCATCTGGAAGGGGGTGAAGTCCACAGGCAAGGTGGTGTACTTCACGGCC
ACATTTCCTTACCTCATGCTGGTGGTCCTGTTAATTCGAGGGGTGACGTTGCCTGGGGCA
GCCCAAGGAATTCAGTTTTACCTGTACCCAAACCTCACGCGTCTGTGGGATCCCCAGGTG
TGGATGGATGCAGGCACCCAGATATTCTTCTCCTTCGCCATCTGTCTTGGGTGCCTGACA
GCCCTGGGCAGCTACAACAAGTACCACAACAACTGCTACAGCGGCACCAGCTTTGTGGCC
GGCTTTGCCATCTTCTCCATCCTGGGCTTCATGTCTCAGGAGCAGGGGGTGCCCATTTCT
GAGGTGGCCGAGTCAGGCCCTGGCCTGGCTTTCATCGCTTACCCGCGGGCTGTGGTGATG
CTGCCCTTCTCTCCTCTCTGGGCCTGCTGTTTCTTCTTCATGGTCGTTCTCCTGGGACTG
GATAGCCAGTTTGTGTGTGTAGAAAGCCTGGTGACAGCGCTGGTGGACATGTACCCTCAC
GTGTTCCGCAAGAAGAACCGGAGGGAAGTCCTCATCCTTGGAGTATCTGTCGTCTCCTTC
CCTGTGGGGCTGATCATGCTCACAGAGGGCGGAATGTACGTGTTCCAGCTCTTTGACTAC
TATGCGGCCAGTGGCATGTGCCTCCTGTTCGTGGCCATCTTCGAGTCCCTCTGTGTGGCT
TGGGTTTACGGAGCCAAGCGCTTCTACGACAACATCGAAGACATGATTGGGTACAGGCCA
TGGCCTCTTATCAAATACTGTTGGCTCTTCCTCACACCAGCTGTGTGCACAGCCACCTTT
CTCTTCTCCCTGATAAAGTACACTCCGCTGACCTACAACAAGAAGTACACGTACCCGTGG
TGGGGCGATGCCCTGGGCTGGCTCCTGGCTCTGTCCTCCTGGTCTGCATTCCTGCCTGGA
GCCTCTACAGACTCGGAACCCTCAAGGGCCCCTTCAGAGAGAGAATCCGTCAGCTCATGT
GCCCAGCCGAGGACCTGCCCCAGCGGAACCCAGCAGGACCCTCGGCTCCCGCCACCCCCA
GGACCTCACTGCTCAGACTCACAGAGCTAG

# Macromolecular_Interacting_Partner_27_GenBank_ID_Gene:
U76343

# Macromolecular_Interacting_Partner_27_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_27_Locus:
12p13.3

# Macromolecular_Interacting_Partner_27_SNPs:
rs577294; rs2289954; rs16928571; rs524468; rs495973; rs527118; rs4980870; rs555044; rs520932; rs124440; rs809517; rs11613331; rs525631; rs10744557; rs11613826; rs7960083; rs511230; rs1003452; rs2053736; rs3782862; rs7303797; rs525797; rs10774021; rs485514; rs497740; rs17800720; rs11610536; rs577140; rs1446583; rs11062126; rs570680; rs4980869; rs523169; rs797733; rs3782867; rs2289958; rs3782858; rs580420; rs11609381; rs11062163; rs11615492; rs3782866; rs7298813; rs7961138; rs10848594; rs505211; rs11610539; rs488192; rs11835796; rs6489355; rs2305164; rs515639; rs10848623; rs11062102; rs7969761; rs11610036; rs2080403; rs10774031; rs505778; rs3782856; rs476646; rs10848644; rs10848638; rs561658; rs7968614; rs7132236; rs2289957; rs3782857; rs552788; rs11062070; rs7960704; rs579366; rs2080402; rs546796; rs10744558; rs1088324; rs727019; rs7960324; rs541182; rs520739; rs535147; rs11062071; rs10774020; rs531709; rs10848639; rs548755; rs496206; rs11612724; rs12580917; rs11062072; rs10774013; rs3782861; rs1092214; rs12579445; rs7969059; rs493624; rs11613232; rs7971952; rs510384; rs1446582; rs538710; rs11062035; rs519566; rs12815498; rs10774019; rs2289956; rs540339; rs7969544; rs505631; rs492540; rs554597; rs10774015; rs512147; rs12826998; rs7312499; rs12830750; rs10744561; rs797765; rs1548904; rs579526; rs500844; rs11062187; rs16928976; rs11062011; rs533112; rs17851999; rs41300044; rs41306938; rs41311243; rs5795911; rs34279667; rs11062182; rs11353420; rs4980871; rs11062180; rs35222334; rs11062178; rs34059463; rs41276698; rs7976795; rs11309524; rs532463; rs530500; rs520825; rs5023845; rs9943840; rs35081451; rs7303844; rs35788657; rs35470225; rs7977022; rs12366824; rs41303001; rs35524331; rs492750; rs11062177; rs11309643; rs11062125; rs35180952; rs34427168; rs7311055; rs11062167; rs34715581; rs34873030; rs41306427; rs35885299; rs506572; rs28880686; rs5795910; rs11062097; rs41302999; rs35137906; rs12146866; rs36022517; rs11444114; rs11615151; rs517874; rs12426630; rs34378007; rs35789455; rs35297718; rs482628; rs2289955; rs11062176; rs3837516; rs1641509; rs41311945; rs12305825; rs11441196; rs35959666; rs4980808; rs534431; rs11295402; rs12825287; rs506600; rs12314545; rs12831369; rs11062179; rs41309403; rs34077284; rs34213228; rs12231963; rs11611619; rs3837515; rs4980868; rs35311301; rs34008663; rs41276700; rs537117; rs36079160; rs505574; rs11062085; rs487252; rs7953163; rs12049966; rs35227285; rs10660448; rs12296696; rs34595456; rs7138725; rs35992702; rs34328511; rs35177774; rs35585051; rs11433818; rs10848647; rs10848650; rs11062211; rs11062212; rs11832251; rs12424772; rs16928441; rs16929048; rs1972582; rs3759373; rs3782860; rs495360; rs499368; rs508450; rs526282; rs529395; rs541273; rs554788; rs555512; rs567487; rs570644; rs7138605; rs7959713; rs7968352; rs7976420; rs797755

# Macromolecular_Interacting_Partner_27_General_References:
11824941

# Macromolecular_Interacting_Partner_27_References:
Not Available

# Macromolecular_Interacting_Partner_28_ID:
8896

# Macromolecular_Interacting_Partner_28_Name:
Vesicular inhibitory amino acid transporter

# Macromolecular_Interacting_Partner_28_Synonyms:
GABA and glycine transporter; Vesicular GABA transporter; hVIAAT; Solute carrier family 32 member 1

# Macromolecular_Interacting_Partner_28_Gene_Name:
SLC32A1

# Macromolecular_Interacting_Partner_28_Protein_Sequence:
>Vesicular inhibitory amino acid transporter
MATLLRSKLSNVATSVSNKSQAKMSGMFARMGFQAATDEEAVGFAHCDDLDFEHRQGLQM
DILKAEGEPCGDEGAEAPVEGDIHYQRGSGAPLPPSGSKDQVGGGGEFGGHDKPKITAWE
AGWNVTNAIQGMFVLGLPYAILHGGYLGLFLIIFAAVVCCYTGKILIACLYEENEDGEVV
RVRDSYVAIANACCAPRFPTLGGRVVNVAQIIELVMTCILYVVVSGNLMYNSFPGLPVSQ
KSWSIIATAVLLPCAFLKNLKAVSKFSLLCTLAHFVINILVIAYCLSRARDWAWEKVKFY
IDVKKFPISIGIIVFSYTSQIFLPSLEGNMQQPSEFHCMMNWTHIAACVLKGLFALVAYL
TWADETKEVITDNLPGSIRAVVNIFLVAKALLSYPLPFFAAVEVLEKSLFQEGSRAFFPA
CYSGDGRLKSWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRL
LWRKLLWHQVFFDVAIFVIGGICSVSGFVHSLEGLIEAYRTNAED

# Macromolecular_Interacting_Partner_28_Number_of_Residues:
525

# Macromolecular_Interacting_Partner_28_Molecular_Weight:
57416

# Macromolecular_Interacting_Partner_28_Theoretical_pI:
6.63

# Macromolecular_Interacting_Partner_28_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_28_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_28_Specific_Function:
Involved in the uptake of GABA and glycine into the synaptic vesicles

# Macromolecular_Interacting_Partner_28_Pathway:
Not Available

# Macromolecular_Interacting_Partner_28_Reaction:
Not Available

# Macromolecular_Interacting_Partner_28_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_28_Signals:
Not Available

# Macromolecular_Interacting_Partner_28_Transmembrane_Regions:
134-154
205-225
243-263
266-286
306-326
342-362
384-404
439-459
462-482
490-510

# Macromolecular_Interacting_Partner_28_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_28_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_28_GenBank_ID_Protein:
17975777

# Macromolecular_Interacting_Partner_28_SwissProt_ID:
VIAAT_HUMAN (Q9H598)

# Macromolecular_Interacting_Partner_28_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_28_Genecard_id:
SLC32A1

# Macromolecular_Interacting_Partner_28_Geneatlas_id:
SLC32A1

# Macromolecular_Interacting_Partner_28_hgnc_id:
HGNC:11018

# Macromolecular_Interacting_Partner_28_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_28_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_28_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_28_Subcellular_Location:
Cytoplasmic vesicle; cytoplasmic vesicle membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_28_Gene_Sequence:
>1578 bp
ATGGCCACCTTGCTCCGCAGCAAGCTGTCCAACGTGGCCACGTCCGTGTCCAACAAGTCC
CAGGCCAAGATGAGCGGCATGTTCGCCAGGATGGGTTTTCAGGCGGCCACGGATGAGGAG
GCGGTGGGCTTCGCGCATTGCGACGACCTCGACTTTGAGCACCGCCAGGGCCTGCAGATG
GACATCCTGAAAGCCGAGGGAGAGCCCTGCGGGGACGAGGGCGCTGAAGCGCCCGTCGAG
GGAGACATCCATTATCAGCGAGGCAGCGGAGCTCCTCTGCCGCCCTCCGGCTCCAAGGAC
CAGGTGGGAGGTGGTGGCGAATTCGGGGGCCACGACAAGCCCAAAATCACGGCGTGGGAG
GCAGGCTGGAACGTGACCAACGCCATCCAGGGCATGTTCGTGCTGGGCCTACCCTACGCC
ATCCTGCACGGCGGCTACCTGGGGTTGTTTCTCATCATCTTCGCCGCCGTTGTGTGCTGC
TACACCGGCAAGATCCTCATCGCGTGCCTGTACGAGGAGAATGAAGACGGCGAGGTGGTG
CGCGTGCGGGACTCGTACGTGGCCATAGCCAACGCCTGCTGCGCCCCGCGCTTCCCAACG
CTGGGCGGCCGAGTGGTGAACGTAGCGCAGATCATCGAGCTGGTGATGACGTGCATCCTG
TACGTGGTGGTGAGTGGCAACCTCATGTACAACAGCTTCCCGGGGCTGCCCGTGTCGCAG
AAGTCCTGGTCCATTATCGCCACGGCCGTGCTGCTGCCTTGCGCCTTCCTTAAGAACCTC
AAGGCCGTGTCCAAGTTCAGTCTGCTGTGCACTCTGGCCCACTTCGTCATCAATATCCTG
GTCATAGCCTACTGTCTATCGCGGGCGCGCGACTGGGCCTGGGAGAAGGTCAAGTTCTAC
ATCGACGTCAAGAAGTTCCCCATCTCCATTGGCATCATCGTGTTCAGCTACACGTCTCAG
ATCTTCCTGCCTTCGCTGGAGGGCAATATGCAGCAGCCCAGCGAGTTCCACTGCATGATG
AACTGGACGCACATCGCAGCCTGCGTGCTCAAGGGCCTCTTCGCGCTCGTCGCCTACCTC
ACCTGGGCCGACGAGACCAAGGAGGTCATCACGGATAACCTGCCCGGCTCCATCCGCGCC
GTGGTCAACATCTTTCTGGTGGCCAAGGCGCTGTTGTCCTATCCTCTGCCATTCTTTGCC
GCTGTCGAGGTGCTGGAGAAGTCGCTCTTCCAGGAAGGCAGCCGCGCCTTTTTCCCGGCC
TGCTACAGCGGCGACGGGCGCCTGAAGTCCTGGGGGCTGACGCTGCGCTGCGCGCTCGTC
GTCTTCACGCTGCTCATGGCCATTTATGTGCCGCACTTCGCGCTGCTCATGGGCCTCACC
GGCAGCCTCACGGGCGCCGGCCTCTGTTTCTTGCTGCCCAGCCTCTTTCACCTGCGCCTG
CTCTGGCGCAAGCTGCTGTGGCACCAAGTCTTCTTCGACGTCGCCATCTTCGTCATCGGC
GGCATCTGCAGCGTGTCCGGCTTCGTGCACTCCCTCGAGGGCCTCATCGAAGCCTACCGA
ACCAACGCGGAGGACTAG

# Macromolecular_Interacting_Partner_28_GenBank_ID_Gene:
AY044836

# Macromolecular_Interacting_Partner_28_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_28_Locus:
20q11.23

# Macromolecular_Interacting_Partner_28_SNPs:
rs34517228; rs16987520; rs16987519; rs6128821; rs6128822; rs8118790; rs6064926; rs4328688; rs6100927; rs6100928; rs6100926; rs2865; rs41304659; rs6100930; rs6027611; rs6027610; rs34068158; rs41311047; rs41305815; rs11477723; rs6027609; rs2867326; rs8125102; rs6071200; rs13042447; rs1010321; rs11700227; rs11906418; rs12624979; rs1321099; rs1322183; rs1406857; rs1406858; rs16987521; rs16987523; rs2180224; rs2246443; rs2246672; rs2246804; rs2247054; rs2263747; rs2757515; rs6027580; rs6064941; rs6071237; rs6092933; rs6092935; rs6092955; rs6100937; rs6100962; rs6128836; rs7274633; rs733549; rs911717; rs911718; rs911719; rs997848; rs998277

# Macromolecular_Interacting_Partner_28_General_References:
12031963; 11780052; 12115694

# Macromolecular_Interacting_Partner_28_References:
Not Available

End of HMDB00112

Beginning of HMDB00114
# Accession_No:
HMDB00114

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-03-28 14:23:21

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Glycerylphosphorylethanolamine

# Description:
A membrane breakdown product resulting from the cleavage of the lipid group from glycerophosphoethanlomine fatty acids (i.e. phosphatidylethanolamine).  It acts as a growth stimulant for hepatocytes.

# Synonyms:
2-aminoethyl ester 1-Glycerophosphoric acid; GPEA; Glycerol 3-phosphoethanolamine; Glycerol 3-phosphorylethanolamine; Glycerophosphoethanolamine; Glycerophosphorylethanolamine; Glyceryl-3-phosphorylethanolamine; Glycerylphosphorylethanolamine; a-Glycerophosphorylethanolamine; alpha-Glycerophosphorylethanolamine

# Chemical_IUPAC_Name:
Phosphoric acid, mono(2-aminoethyl) mono(2,3-dihydroxypropyl) ester

# Chemical_Formula:
C5H14NO6P

# Chemical_Structure:
tbl_chemical:::HMDB00114_ZOOM.png:::11928319404274883

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00114_THUMB.png:::119283193865176535

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Alcohol Phosphates; Phosphate Amines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary alcohol; secondary alcohol; 1,2-diol; primary amine; primary aliphatic amine (alkylamine); phosphoric acid ester

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
215.05588

# Molecular_Weight_Avg:
215.14151

# Smiles_String_isomeric:
OCCN(CC(O)CO)P(O)(O)=O

# Smiles_String_canonical:
OCCN(CC(O)CO)P(O)(O)=O

# KEGG_Compound_ID:
C01233

# BioCyc_ID:
Not Available

# PubChem_CID:
123874

# PubChem_SID:
700620; 10240889; 6740390; 4454

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Not Available

# METLIN_ID:
5151

# Ref_ID:
2293106; 7463068; 1311847; 12203225; 8940245; 10407117

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
1190-00-7

# InChI:
InChI=1/C5H14NO6P/c7-2-1-6(13(10,11)12)3-5(9)4-8/h5,7-9H,1-4H2,(H2,10,11,12)

# Synthesis_Reference:
Not Available

# Melting_Point:
Not Available

# Melting_Point_predicted:
45.9 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
29.2 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-1.90 [Predicted by ALOGPS]; -3.4 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Glycerylphosphorylethanolamine.mol:::1132723807890349042

# SDF_File_[Text]:
tbl_chemical:::HMDB00114.sdf:::119283193497139181

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00114.pdb:::119283193711384020

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Glycerylphosphorylethanolamine.gif:::1132732109765906723

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00114_peaks.txt:::1156309551352860861

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Glycerylphosphorylethanolamine_C.gif:::1132737687040373786

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00114_peaks.txt:::1156310741526888404

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Brain; Liver

# deuterated:
No

# Biofluid_Location:
Not Available

# Concentration_[Normal]:
Not Available


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Alzheimer's Disease; Down's Syndrome; Olivopontocerebellar Atrophy

# Pathway_Names:
Glycerophospholipid metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00564

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5286

# Metabolic_Enzyme_1_Name:
1-O-acylceramide synthase precursor

# Metabolic_Enzyme_1_Synonyms:
ACS; Lysosomal phospholipase A2; Lysophospholipase 3; LPLA2; LCAT-like lysophospholipase; LLPL

# Metabolic_Enzyme_1_Gene_Name:
LYPLA3

# Metabolic_Enzyme_1_Protein_Sequence:
>1Oacylceramide synthase precursor
MGLHLRPYRVGLLPDGLLFLLLLLMLLADPALPAGRHPPVVLVPGDLGNQLEAKLDKPTV
VHYLCSKKTESYFTIWLNLELLLPVIIDCWIDNIRLVYNKTSRATQFPDGVDVRVPGFGK
TFSLEFLDPSKSSVGSYFHTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALREM
IEEMYQLYGGPVVLVAHSMGNMYTLYFLQRQPQAWKDKYIRAFVSLGAPWGGVAKTLRVL
ASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNYTWSPEKVFVQTPTINYTLRDYRKFFQ
DIGFEDGWLMRQDTEGLVEATMPPGVQLHCLYGTGVPTPDSFYYESFPDRDPKICFGDGD
GTVNLKSALQCQAWQSRQEHQVLLQELPGSEHIEMLANATTLAYLKRVLLGP

# Metabolic_Enzyme_1_Number_of_Residues:
412

# Metabolic_Enzyme_1_Molecular_Weight:
46658

# Metabolic_Enzyme_1_Theoretical_pI:
6.72

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
Function:  O-acyltransferase activity
Function:  phosphatidylcholine-sterol O-acyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N- acetylsphingosine and the concomitant release of a lyso- phospholipid. May have weak lysophospholipase activity

# Metabolic_Enzyme_1_Pathway:
Not Available

# Metabolic_Enzyme_1_Reaction:
Not Available

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF02450:LACT

# Metabolic_Enzyme_1_Signals:
1-33

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.1.1.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
4589720

# Metabolic_Enzyme_1_SwissProt_ID:
LYPA3_HUMAN (Q8NCC3)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
LYPLA3

# Metabolic_Enzyme_1_Geneatlas_id:
LYPLA3

# Metabolic_Enzyme_1_hgnc_id:
HGNC:17163

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Lysosome. Secreted protein

# Metabolic_Enzyme_1_Gene_Sequence:
>1239 bp
ATGGGCCTCCACCTCCGCCCCTACCGTGTGGGGCTGCTCCCGGATGGCCTCCTGTTCCTC
TTGCTGCTGCTAATGCTGCTCGCGGACCCAGCGCTCCCGGCCGGACGTCACCCCCCAGTG
GTGCTGGTCCCTGGTGATTTGGGTAACCAACTGGAAGCCAAGCTGGACAAGCCGACAGTG
GTGCACTACCTCTGCTCCAAGAAGACCGAAAGCTACTTCACAATCTGGCTGAACCTGGAA
CTGCTGCTGCCTGTCATCATTGACTGCTGGATTGACAATATCAGGCTGGTTTACAACAAA
ACATCCAGGGCCACCCAGTTTCCTGATGGTGTGGATGTACGTGTCCCTGGCTTTGGGAAG
ACCTTCTCACTGGAGTTCCTGGACCCCAGCAAAAGCAGCGTGGGTTCCTATTTCCACACC
ATGGTGGAGAGCCTTGTGGGCTGGGGCTACACACGGGGTGAGGATGTCCGAGGGGCTCCC
TATGACTGGCGCCGAGCCCCAAATGAAAACGGGCCCTACTTCCTGGCCCTCCGCGAGATG
ATCGAGGAGATGTACCAGCTGTATGGGGGCCCCGTGGTGCTGGTTGCCCACAGTATGGGC
AACATGTACACGCTCTACTTTCTGCAGCGGCAGCCGCAGGCCTGGAAGGACAAGTATATC
CGGGCCTTCGTGTCACTGGGTGCGCCCTGGGGGGGCGTGGCCAAGACCCTGCGCGTCCTG
GCTTCAGGAGACAACAACCGGATCCCAGTCATCGGGCCCCTGAAGATCCGGGAGCAGCAG
CGGTCAGCTGTCTCCACCAGCTGGCTGCTGCCCTACAACTACACATGGTCACCTGAGAAG
GTGTTCGTGCAGACACCCACAATCAACTACACACTGCGGGACTACCGCAAGTTCTTCCAG
GACATCGGCTTTGAAGATGGCTGGCTCATGCGGCAGGACACAGAAGGGCTGGTGGAAGCC
ACGATGCCACCTGGCGTGCAGCTGCACTGCCTCTATGGCACTGGCGTCCCCACACCAGAC
TCCTTCTACTATGAGAGCTTCCCTGACCGTGACCCTAAAATCTGCTTTGGTGACGGCGAT
GGTACTGTGAACTTGAAGAGTGCCCTGCAGTGCCAGGCCTGGCAGAGCCGCCAGGAGCAC
CAAGTGTTGCTGCAGGAGCTGCCAGGCAGCGAGCACATCGAGATGCTGGCCAACGCCACC
ACCCTGGCCTATCTGAAACGTGTGCTCCTTGGGCCCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AB017494

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_1_Locus:
16q22.1

# Metabolic_Enzyme_1_SNPs:
rs3743739; rs7672; rs9935022; rs1975802; rs2290700; rs16957784; rs12446418; rs1971546; rs3826164; rs10500543; rs12444188; rs8062085; rs12600062; rs2290699; rs17688065; rs11075670; rs8063214; rs10852439; rs17688076; rs7189794; rs28565410; rs34573759; rs34767979; rs11550043; rs9922331; rs35744179; rs3180464; rs34645528; rs11368218; rs34967472; rs12918044; rs3068687; rs36037115; rs5817633; rs12918043; rs28536091; rs35588224; rs35048006; rs3214854; rs12444774; rs12918145; rs36121098; rs3785110; rs8053594; rs9923137; rs10695552; rs168770; rs12324926; rs12918064; rs34546790; rs7184506; rs7189381; rs12325587; rs7189155; rs12324938; rs35155877; rs12102971; rs12447119; rs12596500; rs12924125; rs2863981; rs7184821; rs7187202; rs8056893; rs9930792; rs9933029

# Metabolic_Enzyme_1_General_References:
10092508; 12975309; 11790796

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5295

# Metabolic_Enzyme_2_Name:
Acyl-protein thioesterase 2

# Metabolic_Enzyme_2_Synonyms:
Lysophospholipase II; LPL- I

# Metabolic_Enzyme_2_Gene_Name:
LYPLA2

# Metabolic_Enzyme_2_Protein_Sequence:
>Acylprotein thioesterase 2
MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAP
RIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGG
FSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPMVP
VRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV

# Metabolic_Enzyme_2_Number_of_Residues:
231

# Metabolic_Enzyme_2_Molecular_Weight:
24737

# Metabolic_Enzyme_2_Theoretical_pI:
7.25

# Metabolic_Enzyme_2_GO_Classification:
Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity

# Metabolic_Enzyme_2_Pathway:
Not Available

# Metabolic_Enzyme_2_Reaction:
Not Available

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF02230:Abhydrolase_2

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.1.1.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
3859560

# Metabolic_Enzyme_2_SwissProt_ID:
LYPA2_HUMAN (O95372)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
LYPLA2

# Metabolic_Enzyme_2_Geneatlas_id:
LYPLA2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:6738

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm (Probable)

# Metabolic_Enzyme_2_Gene_Sequence:
>696 bp
ATGTGTGGTAACACCATGTCTGTGCCCCTGCTCACCGATGCTGCCACCGTGTCTGGAGCT
GAGCGGGAAACGGCCGCGGTTATTTTTTTACATGGACTTGGAGACACAGGGCACAGCTGG
GCTGACGCCCTCTCCACCATCCGGCTCCCTCACGTCAAGTACATCTGTCCCCATGCGCCT
AGGATCCCTGTGACCCTCAACATGAAGATGGTGATGCCCTCCTGGTTTGACCTGATGGGG
CTGAGTCCAGATGCCCCAGAGGACGAGGCTGGCATCAAGAAGGCAGCAGAGAACATCAAG
GCCTTGATTGAGCATGAAATGAAGAACGGGATCCCTGCCAATCGAATCGTCCTGGGAGGC
TTTTCACAGGGCGGGGCCCTGTCCCTCTACACGGCCCTCACCTGCCCCCACCCTCTGGCT
GGCATCGTGGCGTTGAGCTGCTGGCTGCCTCTGCACCGGGCCTTCCCCCAGGCAGCTAAT
GGCAGTGCCAAGGACCTGGCCATACTCCAGTGCCATGGGGAGCTGGACCCCATGGTGCCC
GTACGGTTTGGGGCCCTGACGGCTGAGAAGCTCCGGTCTGTTGTCACACCTGCCAGGGTC
CAGTTCAAGACATACCCGGGTGTCATGCACAGCTCCTGTCCTCAGGAGATGGCAGCTGTG
AAGGAATTTCTTGAGAAGCTGCTGCCTCCTGTCTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF098668

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_2_Locus:
1p36.12-p35.1

# Metabolic_Enzyme_2_SNPs:
rs2502985; rs2232982; rs2232979; rs11584220; rs2232978; rs2232985; rs2232986; rs2232984; rs3835423; rs2232976; rs2232977; rs2232981; rs2232980; rs2232983; rs2232975; rs35791072; rs1042436; rs1046924; rs1049988; rs11714; rs12031592; rs12131539; rs15778; rs1803612; rs1803613; rs2076343; rs2473381; rs2473382; rs28940882; rs28940883; rs28940885; rs3177810; rs3177811; rs3177814; rs3179862; rs3180382; rs3180383; rs3180545; rs3180546; rs3180547; rs3180549; rs3203593; rs3209973; rs6692104; rs760941

# Metabolic_Enzyme_2_General_References:
Not Available

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5289

# Metabolic_Enzyme_3_Name:
Cytosolic phospholipase A2

# Metabolic_Enzyme_3_Synonyms:
cPLA2; Phospholipase A2 group IVA[Includes: Phospholipase A2; Phosphatidylcholine 2- acylhydrolase; Lysophospholipase

# Metabolic_Enzyme_3_Gene_Name:
PLA2G4A

# Metabolic_Enzyme_3_Protein_Sequence:
>Cytosolic phospholipase A2
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRT
RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEV
PFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEG
LHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSH
PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIG
ETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYG
TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEE
LENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFN
TREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDV
KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN
KLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYKAPGVPRETE
EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRR
QNPSRCSVSLSNVEARRFFNKEFLSKPKA

# Metabolic_Enzyme_3_Number_of_Residues:
749

# Metabolic_Enzyme_3_Molecular_Weight:
85212

# Metabolic_Enzyme_3_Theoretical_pI:
5.03

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  lipase activity
Function:  phospholipase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  phospholipid metabolism
Process:  phospholipid catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response

# Metabolic_Enzyme_3_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_3_Reaction:
2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00168:C2;
PF01735:PLA2_B

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.1.1.4;EC 3.1.1.5

# Metabolic_Enzyme_3_GenBank_ID_Protein:
190007

# Metabolic_Enzyme_3_SwissProt_ID:
PA24A_HUMAN (P47712)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
PLA2G4A

# Metabolic_Enzyme_3_Geneatlas_id:
PLA2G4A

# Metabolic_Enzyme_3_hgnc_id:
HGNC:9035

# Metabolic_Enzyme_3_PDB_ID:
1CJY

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion

# Metabolic_Enzyme_3_Gene_Sequence:
>2250 bp
ATGTCATTTATAGATCCTTACCAGCACATTATAGTGGAGCACCAGTATTCCCACAAGTTT
ACGGTAGTGGTGTTACGTGCCACCAAAGTGACAAAGGGGGCCTTTGGTGACATGCTTGAT
ACTCCAGATCCCTATGTGGAACTTTTTATCTCTACAACCCCTGACAGCAGGAAGAGAACA
AGACATTTCAATAATGACATAAACCCTGTGTGGAATGAGACCTTTGAATTTATTTTGGAT
CCTAATCAGGAAAATGTTTTGGAGATTACGTTAATGGATGCCAATTATGTCATGGATGAA
ACTCTAGGGACAGCAACATTTACTGTATCTTCTATGAAGGTGGGAGAAAAGAAAGAAGTT
CCTTTTATTTTCAACCAAGTCACTGAAATGGTTCTAGAAATGTCTCTTGAAGTTTGCTCA
TGCCCAGACCTACGATTTAGTATGGCTCTGTGTGATCAGGAGAAGACTTTCAGACAACAG
AGAAAAGAACACATAAGGGAGAGCATGAAGAAACTCTTGGGTCCAAAGAATAGTGAAGGA
TTGCATTCTGCACGTGATGTGCCTGTGGTAGCCATATTGGGTTCAGGTGGGGGTTTCCGA
GCCATGGTGGGATTCTCTGGTGTGATGAAGGCATTATACGAATCAGGAATTCTGGATTGT
GCTACCTACGTTGCTGGTCTTTCTGGCTCCACCTGGTATATGTCAACCTTGTATTCTCAC
CCTGATTTTCCAGAGAAAGGGCCAGAGGAGATTAATGAAGAACTAATGAAAAATGTTAGC
CACAATCCCCTTTTACTTCTCACACCACAGAAAGTTAAAAGATATGTTGAGTCTTTATGG
AAGAAGAAAAGCTCTGGACAACCTGTCACCTTTACTGATATCTTTGGGATGTTAATAGGA
GAAACACTAATTCATAATAGAATGAATACTACTCTGAGCAGTTTGAAGGAAAAAGTTAAT
ACTGCACAATGCCCTTTACCTCTTTTCACCTGTCTTCATGTCAAACCTGACGTTTCAGAG
CTGATGTTTGCAGATTGGGTTGAATTTAGTCCATACGAAATTGGCATGGCTAAATATGGT
ACTTTTATGGCTCCCGACTTATTTGGAAGCAAATTTTTTATGGGAACAGTCGTTAAGAAG
TATGAAGAAAACCCCTTGCATTTCTTAATGGGTGTCTGGGGCAGTGCCTTTTCCATATTG
TTCAACAGAGTTTTGGGCGTTTCTGGTTCACAAAGCAGAGGCTCCACAATGGAGGAAGAA
TTAGAAAATATTACCACAAAGCATATTGTGAGTAATGATAGCTCGGACAGTGATGATGAA
TCACACGAACCCAAAGGCACTGAAAATGAAGATGCTGGAAGTGACTATCAAAGTGATAAT
CAAGCAAGTTGGATTCATCGTATGATAATGGCCTTGGTGAGTGATTCAGCTTTATTCAAT
ACCAGAGAAGGACGTGCTGGGAAGGTACACAACTTCATGCTGGGCTTGAATCTCAATACA
TCTTATCCACTGTCTCCTTTGAGTGACTTTGCCACACAGGACTCCTTTGATGATGATGAA
CTGGATGCAGCTGTAGCAGATCCTGATGAATTTGAGCGAATATATGAGCCTCTGGATGTC
AAAAGTAAAAAGATTCATGTAGTGGACAGTGGGCTCACATTTAACCTGCCGTATCCCTTG
ATACTGAGACCTCAGAGAGGGGTTGATCTCATAATCTCCTTTGACTTTTCTGCAAGGCCA
AGTGACTCTAGTCCTCCGTTCAAGGAACTTCTACTTGCAGAAAAGTGGGCTAAAATGAAC
AAGCTCCCCTTTCCAAAGATTGATCCTTATGTGTTTGATCGGGAAGGGCTGAAGGAGTGC
TATGTCTTTAAACCCAAGAATCCTGATATGGAGAAAGATTGCCCAACCATCATCCACTTT
GTTCTGGCCAACATCAACTTCAGAAAGTACAAGGCTCCAGGTGTTCCAAGGGAAACTGAG
GAAGAGAAAGAAATCGCTGACTTTGATATTTTTGATGACCCAGAATCACCATTTTCAACC
TTCAATTTTCAATATCCAAATCAAGCATTCAAAAGACTACATGATCTTATGCACTTCAAT
ACTCTGAACAACATTGATGTGATAAAAGAAGCCATGGTTGAAAGCATTGAATATAGAAGA
CAGAATCCATCTCGTTGCTCTGTTTCCCTTAGTAATGTTGAGGCAAGAAGATTTTTCAAC
AAGGAGTTTCTAAGTAAACCCAAAGCATAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M72393

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_3_Locus:
1q25

# Metabolic_Enzyme_3_SNPs:
rs2307198; rs12720691; rs10752976; rs4651331; rs2076075; rs7535459; rs12720707; rs11591148; rs12720485; rs3820185; rs10798059; rs12022299; rs12720496; rs1473676; rs12070719; rs6682761; rs6669230; rs6425051; rs10911930; rs11578084; rs6425050; rs11455181; rs10489406; rs4651330; rs12720495; rs2205897; rs9645303; rs16825998; rs12720708; rs7518131; rs12720488; rs12065442; rs12720490; rs12097836; rs10911927; rs7522183; rs12720486; rs2179189; rs2223307; rs2891262; rs1980444; rs2223309; rs2383555; rs726706; rs1018378; rs6672324; rs1474590; rs4336803; rs10798065; rs1569480; rs7555326; rs10737277; rs1160719; rs4650708; rs10752988; rs7545121; rs12062681; rs10911946; rs12068233; rs6678708; rs6690185; rs10911943; rs10798070; rs1569479; rs6682481; rs7542180; rs7519192; rs969357; rs932476; rs10752989; rs10911948; rs10911971; rs10798067; rs12072973; rs6697116; rs2307199; rs10737272; rs1033410; rs6678709; rs6698103; rs4651343; rs10752985; rs7554339; rs5027750; rs2383556; rs10798062; rs6683363; rs10911945; rs7542659; rs2207209; rs6695515; rs10911949; rs1003348; rs1977064; rs969358; rs2223308; rs10752983; rs2064115; rs6697145; rs763419; rs6683515; rs2891263; rs7540602; rs10157410; rs10911947; rs2307200; rs10798069; rs10911944; rs2383553; rs2891264; rs2049963; rs10911953; rs2383554; rs11587539; rs10911956; rs6661772; rs1980445; rs10489410; rs10911937; rs1555205; rs12129917; rs10798076; rs10489409; rs17591814; rs6425064; rs4650706; rs10911973; rs2024656; rs6682706; rs10911955; rs2076675; rs4272579; rs12720576; rs10798064; rs12404877; rs10911968; rs10911972; rs12720500; rs6425065; rs2273169; rs10911935; rs16826051; rs12567822; rs4650711; rs12720573; rs6425059; rs12720528; rs12720566; rs6666834; rs10489408; rs12564966; rs4651337; rs6686860; rs10911969; rs12720639; rs10798063; rs4651339; rs7547993; rs2383551; rs10911934; rs3736741; rs12720613; rs12720520; rs2307193; rs12406315; rs12720687; rs12563152; rs12066585; rs12091045; rs6688584; rs7526089; rs10798075; rs12720571; rs12720699; rs10911966; rs7555140; rs4651336; rs6704304; rs12720662; rs6664561; rs6685652; rs12749354; rs10798060; rs10911933; rs6693896; rs2307195; rs4433346; rs12726519; rs10489407; rs4402086; rs12720686; rs10798068; rs12720704; rs12720702; rs10911967; rs10737270; rs6425058; rs2891258; rs12720642; rs12353944; rs10737278; rs12720597; rs12131989; rs10911952; rs12042344; rs6686848; rs12720541; rs7526761; rs12720554; rs12720526; rs12353945; rs12409191; rs10911942; rs6425053; rs2307196; rs10737276; rs12746200; rs12401750; rs12139172; rs12720667; rs2064471; rs10752981; rs6699187; rs11576330; rs2223310; rs12720536; rs6665700; rs10752979; rs7521601; rs12567046; rs6678716; rs6696406; rs16826049; rs12144159; rs12720497; rs6662822; rs6425054; rs10737275; rs10911938; rs6683416; rs6425066; rs2307197; rs1555202; rs6690542; rs12720502; rs12720519; rs10688954; rs12720535; rs7416329; rs2142761; rs10752982; rs12407699; rs1555204; rs12128551; rs6683619; rs6662687; rs10752978; rs12131535; rs10737274; rs6678825; rs10752977; rs12073758; rs7522213; rs1160718; rs6425067; rs12568962; rs10911963; rs10157338; rs11802826; rs4651334; rs16826045; rs6656909; rs12073712; rs6685207; rs7547156; rs12720586; rs7541946; rs12720696; rs6691054; rs6672835; rs6695425; rs12720584; rs12720603; rs16670; rs6675898; rs12720572; rs35782442; rs4650712; rs12567071; rs2891261; rs12720625; rs16826065; rs12720565; rs6680308; rs16826055; rs6699070; rs12720537; rs12720508; rs12720605; rs10798073; rs12720700; rs12136279; rs7532616; rs6685195; rs12720658; rs16826181; rs12405420; rs12720650; rs12720654; rs12720622; rs10911951; rs6688358; rs12720556; rs12720680; rs12720560; rs12720514; rs2223909; rs12720552; rs12720527; rs12720637; rs12720549; rs6703952; rs10737273; rs10157406; rs975762; rs12720672; rs6683622; rs12720570; rs12720664; rs6425062; rs10798066; rs4276871; rs11805429; rs12720644; rs10911960; rs12720516; rs12720505; rs12720548; rs12720675; rs11806629; rs6675166; rs12720630; rs10911950; rs12720539; rs10732978; rs12720550; rs12720530; rs12720559; rs12691467; rs11577826; rs12720660; rs6700651; rs6675578; rs12720531; rs6685468; rs2207212; rs6690278; rs9803785; rs4650705; rs12720673; rs17601344; rs12720615; rs12567135; rs7547623; rs10737271; rs5007825; rs4651333; rs10798072; rs12720610; rs12720534; rs17591849; rs10798077; rs16826212; rs2223306; rs6683421; rs12720692; rs12720564; rs12720595; rs17526478; rs6668908; rs12720504; rs16826197; rs12720563; rs6425052; rs12090109; rs16826185; rs12720655; rs7534926; rs6688401; rs4650715; rs12720555; rs12720580; rs10911959; rs10752980; rs12720677; rs12720517; rs10158652; rs12567058; rs1555201; rs9804084; rs10798061; rs12720547; rs2383552; rs12720705; rs10911964; rs6688292; rs16826066; rs1033409; rs12720551; rs725892; rs5007826; rs12720628; rs12720638; rs12720582; rs12720633; rs2205898; rs11802050; rs10911931; rs12720511; rs4650709; rs10911958; rs12720684; rs10798074; rs1980446; rs12720557; rs12720617; rs12125857; rs12720676; rs7512281; rs12720561; rs16826060; rs11799495; rs12720594; rs2891259; rs7542836; rs6680303; rs7555537; rs12720690; rs10911965; rs12720544; rs16826042; rs2223305; rs12720581; rs7514702; rs12720634; rs5007824; rs6425055; rs6687896; rs4651332; rs12720689; rs12720694; rs12720669; rs12720656; rs2207213; rs979924; rs12720709; rs12720715; rs6684111; rs12720714; rs12720711; rs12720484; rs2066730; rs12720588; rs34758865; rs12720706; rs34500623; rs34278354; rs12720493; rs36079774; rs35180943; rs34635375; rs35145197; rs34795932; rs35339490; rs12093847; rs12744150; rs3795405; rs11543184; rs12095150; rs12720491; rs34716672; rs34429516; rs7521834; rs6662798; rs12720492; rs2307194; rs35977655; rs7525336; rs12734741; rs36062883; rs35641837; rs12084339; rs28595275; rs35960872; rs10911929; rs34827324; rs11810276; rs12070830; rs12720494; rs10651334; rs12720487; rs10911928; rs34397242; rs11577918; rs12734740; rs35762270; rs28679753; rs34496849; rs34438674; rs10566895; rs5779305; rs12033196; rs34724808; rs34832532; rs34045840; rs34986389; rs7513536; rs34537878; rs35209416; rs12720614; rs12720665; rs10712560; rs12720562; rs35723333; rs10609057; rs11371525; rs4650710; rs11406614; rs10695580; rs34215604; rs11371082; rs12720620; rs12720545; rs12742851; rs6702522; rs12720670; rs6671076; rs12720538; rs12720631; rs12720515; rs10911941; rs34711478; rs4651338; rs12720513; rs7522714; rs34670614; rs10911936; rs12720585; rs34385931; rs5779307; rs10752987; rs2207210; rs12720646; rs12720577; rs34340996; rs12753440; rs5779313; rs35091910; rs28633464; rs12751616; rs6679956; rs4007494; rs11399679; rs34101258; rs12128554; rs34680053; rs34586699; rs28412072; rs12720546; rs7527362; rs35773380; rs12720621; rs12022898; rs11390247; rs10700665; rs10592003; rs12720671; rs28691172; rs16826187; rs12745030; rs12720608; rs10911962; rs12720589; rs12720583; rs12720632; rs35131542; rs6682327; rs35260952; rs12720697; rs7544607; rs34405767; rs28676882; rs41264626; rs34416417; rs35443164; rs12566020; rs35801522; rs12032535; rs35069250; rs6691582; rs12095733; rs10752984; rs35183959; rs34391401; rs2205899; rs2205900; rs12129429; rs35047746; rs35174355; rs12131723; rs10911961; rs34709541; rs33956999; rs34677530; rs35412398; rs12088010; rs12720503; rs12720553; rs35618673; rs12141266; rs6696994; rs12720579; rs12720606; rs34191261; rs35003727; rs12720590; rs2207211; rs34356253; rs12071785; rs6675261; rs7546816; rs10627684; rs12720698; rs33958012; rs7524685; rs12122892; rs34414453; rs17592348; rs6683074; rs34543034; rs35037006; rs36037957; rs12063845; rs34089378; rs35264080; rs28606018; rs7413826; rs10538195; rs12720567; rs12074730; rs34098374; rs2383557; rs2891260; rs10911940; rs36020072; rs5779309; rs7545760; rs12720701; rs12720661; rs4540601; rs10708783; rs12720529; rs12720506; rs12057343; rs12720627; rs12720693; rs12720509; rs10631853; rs12720663; rs35389587; rs10708367; rs34107747; rs35813341; rs12720681; rs6662570; rs5779311; rs12742431; rs12738756; rs12758086; rs5779312; rs35947118; rs10702515; rs12720578; rs6703998; rs12720521; rs35425521; rs35800521; rs12720643; rs12720518; rs12720674; rs41264620; rs12720592; rs28493593; rs35050511; rs41516146; rs33948033; rs11375182; rs28863289; rs2017443; rs12720635; rs35712617; rs12720558; rs12720682; rs10674434; rs10609058; rs12720679; rs34796725; rs11388924; rs12720499; rs12720525; rs12720666; rs28896572; rs10599543; rs34632328; rs34437304; rs6425063; rs12720540; rs34350773; rs1467392; rs4650714; rs7536112; rs34147625; rs12720626; rs12720522; rs10596911; rs12720629; rs6685936; rs34920672; rs12730988; rs12121329; rs7526859; rs11428922; rs16826040; rs34398848; rs12720657; rs12720533; rs5014276; rs12720636; rs5779310; rs12720510; rs12744618; rs6425060; rs10634937; rs12720695; rs12720618; rs12720685; rs34820266; rs12125608; rs35455351; rs12720678; rs12720587; rs10911939; rs34441009; rs12744872; rs34503201; rs12720523; rs7520075; rs12720542; rs11426942; rs12088931; rs12143244; rs10633079; rs12720703; rs11460224; rs35869038; rs6678801; rs12128380; rs6675277; rs2143998; rs34952820; rs33991046; rs10578509; rs12720507; rs12720641; rs6425061; rs6674263; rs41264622; rs11268618; rs12720575; rs12730485; rs34117619; rs12720524; rs3060324; rs12720640; rs11307887; rs12720543; rs35673805; rs12720569; rs12129578; rs12720601; rs12720683; rs12143166; rs12747953; rs12720668; rs5007827; rs12409076; rs6670830; rs1555203; rs6695438; rs11441392; rs10647657; rs34948178; rs35146633; rs11314983; rs34814979; rs12097804; rs10689140; rs12720574; rs12720688; rs12077935; rs11387651; rs34068761; rs5007828; rs34866477; rs12730349; rs12720653; rs10707298; rs28878026; rs28634506; rs10709187; rs35257640; rs35387925; rs34796478; rs34017667; rs10752986; rs4262498; rs11410376; rs34113977; rs28749294; rs34023737; rs5779306; rs12720498; rs35843046; rs10585011; rs12720512; rs35114616; rs34490217; rs12744998; rs7416510; rs12720616; rs35566402; rs35454348; rs11320837; rs10657628; rs35523045; rs11805955; rs35126168; rs41519945; rs41264624; rs36064066; rs10647022; rs4650713; rs12720501; rs12071782; rs35214657; rs10603183; rs34029312; rs6678891; rs12720593; rs7551458; rs10681360; rs12123893; rs7523149; rs41453146; rs12720483; rs10158368; rs7556320; rs11802141; rs12066562; rs12720710; rs12066511; rs5779304; rs12092415; rs12720712; rs12720713; rs12066519; rs12066344; rs10752990; rs10798078; rs10911976; rs10911978; rs11590854; rs12037836; rs12746284; rs1474797; rs2143999; rs2144000; rs4651345; rs6661727; rs6696144; rs7414079; rs7544719; rs761517

# Metabolic_Enzyme_3_General_References:
1904318; 1869522; 8381049; 11416127; 9430701; 9665851

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5300

# Metabolic_Enzyme_4_Name:
Cardiotrophin-like cytokine factor 1 precursor

# Metabolic_Enzyme_4_Synonyms:
B cell-stimulating factor 3; BSF-3; Novel neurotrophin-1; NNT-1

# Metabolic_Enzyme_4_Gene_Name:
CLCF1

# Metabolic_Enzyme_4_Protein_Sequence:
>Cardiotrophinlike cytokine factor 1 precursor
MDLRAGDSWGMLACLCTVLWHLPAVPALNRTGDPGPGPSIQKTYDLTRYLEHQLRSLAGT
YLNYLGPPFNEPDFNPPRLGAETLPRATVDLEVWRSLNDKLRLTQNYEAYSHLLCYLRGL
NRQAATAELRRSLAHFCTSLQGLLGSIAGVMAALGYPLPQPLPGTEPTWTPGPAHSDFLQ
KMDDFWLLKELQTWLWRSAKDFNRLKKKMQPPAAAVTLHLGAHGF

# Metabolic_Enzyme_4_Number_of_Residues:
225

# Metabolic_Enzyme_4_Molecular_Weight:
25176

# Metabolic_Enzyme_4_Theoretical_pI:
8.61

# Metabolic_Enzyme_4_GO_Classification:
Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor

# Metabolic_Enzyme_4_Pathway:
Not Available

# Metabolic_Enzyme_4_Reaction:
Not Available

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF06875:PRF

# Metabolic_Enzyme_4_Signals:
1-27

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.1.1.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
6007641

# Metabolic_Enzyme_4_SwissProt_ID:
CLCF1_HUMAN (Q9UBD9)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CLCF1

# Metabolic_Enzyme_4_Geneatlas_id:
CLCF1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:17412

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_4_Gene_Sequence:
>678 bp
ATGGACCTCCGAGCAGGGGACTCGTGGGGGATGTTAGCGTGCCTGTGCACGGTGCTCTGG
CACCTCCCTGCAGTGCCAGCTCTCAATCGCACAGGGGACCCAGGGCCTGGCCCCTCCATC
CAGAAAACCTATGACCTCACCCGCTACCTGGAGCACCAACTCCGCAGCTTGGCTGGGACC
TATCTGAACTACCTGGGCCCCCCTTTCAACGAGCCAGACTTCAACCCTCCCCGCCTGGGG
GCAGAGACTCTGCCCAGGGCCACTGTTGACTTGGAGGTGTGGCGAAGCCTCAATGACAAA
CTGCGGCTGACCCAGAACTACGAGGCCTACAGCCACCTTCTGTGTTACTTGCGTGGCCTC
AACCGTCAGGCTGCCACTGCTGAGCTGCGCCGCAGCCTGGCCCACTTCTGCACCAGCCTC
CAGGGCCTGCTGGGCAGCATTGCGGGCGTCATGGCAGCTCTGGGCTACCCACTGCCCCAG
CCGCTGCCTGGGACTGAACCCACTTGGACTCCTGGCCCTGCCCACAGTGACTTCCTCCAG
AAGATGGACGACTTCTGGCTGCTGAAGGAGCTGCAGACCTGGCTGTGGCGCTCGGCCAAG
GACTTCAACCGGCTCAAGAAGAAGATGCAGCCTCCAGCAGCTGCAGTCACCCTGCACCTG
GGGGCTCATGGCTTCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF176911

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_4_Locus:
11q13.3

# Metabolic_Enzyme_4_SNPs:
rs867193; rs4930197; rs1790738; rs3781941; rs3781942; rs11826923; rs11227780; rs1638569; rs1790737; rs12788752; rs1790739; rs1790740; rs3758943; rs34057094; rs35896036; rs35385218; rs35544864; rs4024257; rs3837414; rs35112616; rs885763; rs35983106; rs5792415; rs10578684; rs34865354; rs10666079; rs12790741; rs5792414; rs885764; rs34198998; rs3837416; rs35361219; rs34641131; rs10666811; rs35573072; rs3837415; rs34550280; rs7484118; rs35764861; rs4320957; rs11227779; rs11227778; rs12222500; rs12288324; rs1419861; rs1638566; rs1638567; rs1638570; rs1638571; rs1638572; rs1790731; rs1790735; rs34087937; rs34468513; rs35176549; rs3909168; rs4930198; rs869154

# Metabolic_Enzyme_4_General_References:
10500198; 10448081

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5285

# Metabolic_Enzyme_5_Name:
Acyl-protein thioesterase 1

# Metabolic_Enzyme_5_Synonyms:
Lysophospholipase 1; Lysophospholipase I

# Metabolic_Enzyme_5_Gene_Name:
LYPLA1

# Metabolic_Enzyme_5_Protein_Sequence:
>Acylprotein thioesterase 1
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRP
VTLNMNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQ
GGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLM
FGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID

# Metabolic_Enzyme_5_Number_of_Residues:
230

# Metabolic_Enzyme_5_Molecular_Weight:
24670

# Metabolic_Enzyme_5_Theoretical_pI:
6.77

# Metabolic_Enzyme_5_GO_Classification:
Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Also has low lysophospholipase activity

# Metabolic_Enzyme_5_Pathway:
Not Available

# Metabolic_Enzyme_5_Reaction:
Not Available

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF02230:Abhydrolase_2

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.1.1.5

# Metabolic_Enzyme_5_GenBank_ID_Protein:
3415123

# Metabolic_Enzyme_5_SwissProt_ID:
LYPA1_HUMAN (O75608)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
LYPLA1

# Metabolic_Enzyme_5_Geneatlas_id:
LYPLA1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:6737

# Metabolic_Enzyme_5_PDB_ID:
1FJ2

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>693 bp
ATGTGCGGCAATAACATGTCAACCCCGCTGCCCGCCATCGTGCCCGCCGCCCGGAAGGCC
ACCGCTGCGGTGATTTTCCTGCATGGATTGGGAGATACTGGGCACGGATGGGCAGAAGCC
TTTGCAGGTATCAGAAGTTCACATATCAAATATATCTGCCCGCATGCGCCTGTTAGGCCT
GTTACATTAAATATGAACGTGGCTATGCCTTCATGGTTTGATATTATTGGGCTTTCACCA
GATTCACAGGAGGATGAATCTGGGATTAAACAGGCAGCAGAAAATATAAAAGCTTTGATT
GATCAAGAAGTGAAGAATGGCATTCCTTCTAACAGAATTATTTTGGGAGGGTTTTCTCAG
GGAGGAGCTTTATCTTTATATACTGCCCTTACCACACAGCAGAAACTGGCAGGTGTCACT
GCACTCAGTTGCTGGCTTCCACTTCGGGCTTCCTTTCCACAGGGTCCTATCGGTGGTGCT
AATAGAGATATTTCTATTCTCCAGTGCCACGGGGATTGTGACCCTTTGGTTCCCCTGATG
TTTGGTTCTCTTACGGTGGAAAAACTAAAAACATTGGTGAATCCAGCCAATGTGACCTTT
AAAACCTATGAAGGTATGATGCACAGTTCGTGTCAACAGGAAATGATGGATGTCAAGCAA
TTCATTGATAAACTCCTACCTCCAATTGATTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AF081281

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_5_Locus:
8q11.23

# Metabolic_Enzyme_5_SNPs:
rs16919923; rs6473905; rs8822; rs4737486; rs4506187; rs7829394; rs6473908; rs6983694; rs11998000; rs7003793; rs7844299; rs11994629; rs4737485; rs6473907; rs7008593; rs11986605; rs7463083; rs16919753; rs7007031; rs10504160; rs10112111; rs11988830; rs2037068; rs10101097; rs11988859; rs11775545; rs16919924; rs4737479; rs7011379; rs16919750; rs11993367; rs7839276; rs11549451; rs4310181; rs4486181; rs1044691; rs35038027; rs1044604; rs11549452; rs11549447; rs11549455; rs4475455; rs11549454; rs36051350; rs35130790; rs7005653; rs7836760; rs13269916; rs34705172; rs34207117; rs34578596; rs34866895; rs35292579; rs34317314; rs13279277; rs7820688; rs13275711; rs13269847; rs28369337; rs34967619; rs36030049; rs34232589; rs4737480; rs13279284; rs10090273; rs11780155; rs13265668; rs34599244; rs12019384; rs13259254; rs13259230; rs7815998; rs10101967; rs4427146; rs13269571; rs7833336; rs3054305; rs28452332; rs35231924; rs28749838; rs13276007; rs34951751; rs35405582; rs35023326; rs4480103; rs35882577; rs28813536; rs7001391; rs34805415; rs7001356; rs35772548; rs11994366; rs34478960; rs7004430; rs28437156; rs7822750; rs35162856; rs13250609; rs35188512; rs28397021; rs13277892; rs35318714; rs11992220; rs28533970; rs9643481; rs12056824; rs34135278; rs13263441; rs12676310; rs35672696; rs5891512; rs11288082; rs10958395; rs5891513; rs13262695; rs7357559; rs1828835; rs6981386; rs3054289; rs34828721; rs13269238; rs35106127; rs35890246

# Metabolic_Enzyme_5_General_References:
11080636; 11042152

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5293

# Metabolic_Enzyme_6_Name:
Galactoside-binding soluble lectin 13

# Metabolic_Enzyme_6_Synonyms:
Placental tissue protein 13; Placenta protein 13; PP13; Galectin-13

# Metabolic_Enzyme_6_Gene_Name:
LGALS13

# Metabolic_Enzyme_6_Protein_Sequence:
>Galactosidebinding soluble lectin 13
MSSLPVPYKLPVSLSVGSCVIIKGTPIHSFINDPQLQVDFYTDMDEDSDIAFRFRVHFGN
HVVMNRREFGIWMLEETTDYVPFEDGKQFELCIYVHYNEYEIKVNGIRIYGFVHRIPPSF
VKMVQVSRDISLTSVCVCN

# Metabolic_Enzyme_6_Number_of_Residues:
139

# Metabolic_Enzyme_6_Molecular_Weight:
16119

# Metabolic_Enzyme_6_Theoretical_pI:
5.53

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Has lysophospholipase activity

# Metabolic_Enzyme_6_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_6_Reaction:
2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00337:Gal-bind_lectin

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.1.1.5

# Metabolic_Enzyme_6_GenBank_ID_Protein:
6650760

# Metabolic_Enzyme_6_SwissProt_ID:
PP13_HUMAN (Q9UHV8)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
LGALS13

# Metabolic_Enzyme_6_Geneatlas_id:
LGALS13

# Metabolic_Enzyme_6_hgnc_id:
HGNC:15449

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>420 bp
ATGTCTTCTTTACCCGTGCCATACAAACTGCCTGTGTCTTTGTCTGTTGGTTCCTGCGTG
ATAATCAAAGGGACACCAATCCACTCTTTTATCAATGACCCACAGCTGCAGGTGGATTTC
TACACTGACATGGATGAGGATTCAGATATTGCCTTCCGTTTCCGAGTGCACTTTGGCAAT
CATGTGGTCATGAACAGGCGTGAGTTTGGGATATGGATGTTGGAGGAGACAACAGACTAC
GTGCCCTTTGAGGATGGCAAACAATTTGAGCTGTGCATCTACGTACATTACAATGAGTAT
GAGATAAAGGTCAATGGCATACGCATTTACGGCTTTGTCCATCGAATCCCGCCATCATTT
GTGAAGATGGTGCAAGTGTCGAGAGATATCTCCCTGACCTCAGTGTGTGTCTGCAATTGA


# Metabolic_Enzyme_6_GenBank_ID_Gene:
AF117383

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_6_Locus:
19q13.1

# Metabolic_Enzyme_6_SNPs:
rs2158964; rs2233706; rs2233709; rs17795657; rs1986156; rs1014206; rs3764844; rs2233708; rs12610294; rs3764843; rs10409099; rs11881603; rs2233711; rs1801654; rs2233710; rs2233707; rs9917050; rs28445525; rs12978134; rs10426654; rs2233703; rs35552633; rs3764842; rs2233704; rs2233705; rs2233702; rs10408486; rs10412234; rs10412744; rs10414890; rs10424213; rs10426515; rs10500280; rs11881743; rs12980535; rs12981089; rs12985936; rs2215004; rs4802044; rs6508877; rs6508878; rs682287; rs7245819; rs7251429; rs7259935; rs8106020

# Metabolic_Enzyme_6_General_References:
10527825; 6856484

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5299

# Metabolic_Enzyme_7_Name:
Eosinophil lysophospholipase

# Metabolic_Enzyme_7_Synonyms:
Charcot-Leyden crystal protein; Lysolecithin acylhydrolase; CLC; Galectin-10

# Metabolic_Enzyme_7_Gene_Name:
CLC

# Metabolic_Enzyme_7_Protein_Sequence:
>Eosinophil lysophospholipase
MSLLPVPYTEAASLSTGSTVTIKGRPLVCFLNEPYLQVDFHTEMKEESDIVFHFQVCFGR
RVVMNSREYGAWKQQVESKNMPFQDGQEFELSISVLPDKYQVMVNGQSSYTFDHRIKPEA
VKMVQVWRDISLTKFNVSYLKR

# Metabolic_Enzyme_7_Number_of_Residues:
142

# Metabolic_Enzyme_7_Molecular_Weight:
16481

# Metabolic_Enzyme_7_Theoretical_pI:
7.50

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
May have both lysophospholipase and carbohydrate-binding activities

# Metabolic_Enzyme_7_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_7_Reaction:
2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00337:Gal-bind_lectin

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.1.1.5

# Metabolic_Enzyme_7_GenBank_ID_Protein:
187274

# Metabolic_Enzyme_7_SwissProt_ID:
LPPL_HUMAN (Q05315)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
CLC

# Metabolic_Enzyme_7_Geneatlas_id:
CLC

# Metabolic_Enzyme_7_hgnc_id:
HGNC:2014

# Metabolic_Enzyme_7_PDB_ID:
1QKQ

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Note=Localized in granules from where it may be secreted or transported to other locations in the cell

# Metabolic_Enzyme_7_Gene_Sequence:
>429 bp
ATGTCCCTGCTACCCGTGCCATACACAGAGGCTGCCTCTTTGTCTACTGGTTCTACTGTG
ACAATCAAAGGGCGACCACTTGTCTGTTTCTTGAATGAACCATATCTGCAGGTGGATTTC
CACACTGAGATGAAGGAGGAATCAGACATTGTCTTCCATTTCCAAGTGTGCTTTGGTCGT
CGTGTGGTCATGAACAGCCGTGAGTATGGGGCCTGGAAGCAGCAGGTGGAATCCAAGAAC
ATGCCCTTTCAGGATGGCCAAGAATTTGAACTGAGCATCTCAGTGCTGCCAGATAAGTAC
CAGGTAATGGTCAATGGCCAATCCTCTTACACCTTTGACCATAGAATCAAGCCTGAGGCT
GTGAAGATGGTGCAAGTGTGGAGAGATATCTCCCTGACCAAATTTAATGTCAGCTATTTA
AAGAGATAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
L01664

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_7_Locus:
19q13.1

# Metabolic_Enzyme_7_SNPs:
rs17608; rs384138; rs44049; rs400233; rs367788; rs2238678; rs395892; rs44048; rs364911; rs373449; rs2074926; rs385520; rs446425; rs372902; rs391660; rs7253094; rs396854; rs1985359; rs367529; rs378917; rs437780; rs399641; rs372081; rs385288; rs444963; rs12611412; rs453827; rs383768; rs17709471; rs385240; rs10402365; rs389708; rs375867; rs388648; rs444817; rs391646; rs367156; rs395969; rs390406; rs414423; rs4802054; rs420297; rs2074928; rs431329; rs407640; rs447034; rs425218; rs428007; rs12611334; rs440191; rs7248113; rs7248344; rs7260274; rs425265; rs412211; rs413216; rs1034995; rs12463284; rs375688; rs10407799; rs7249415; rs7249847; rs12977184; rs12977467; rs34365053; rs34895925; rs12978411; rs12978659; rs12978243; rs104734; rs10636410; rs28439433; rs10636409; rs7249381; rs36043907; rs368009; rs34256647; rs34848185; rs34788009; rs2074927; rs375580; rs34953733; rs34190066; rs12980270; rs10408284; rs12979750; rs391333; rs444844; rs7249657; rs9676700; rs12978155; rs12979261; rs35837917; rs28595535; rs2159137; rs403831; rs7260191; rs2108685; rs5828049; rs1034996; rs7258913; rs8101720; rs35110762; rs1034867; rs1034868; rs10402500; rs10409161; rs10421474; rs10422830; rs16973596; rs2108686; rs2355335; rs385563; rs385895; rs410034; rs412884; rs4141230; rs4141231; rs418664; rs440334

# Metabolic_Enzyme_7_General_References:
8419478; 1577491; 9119387; 8747464; 10529229

# Metabolic_Enzyme_7_References:
Not Available

End of HMDB00114

Beginning of HMDB00115
# Accession_No:
HMDB00115

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-14 13:55:37

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Glycolic acid

# Description:
Glycolic acid (or hydroxyacetic acid) is the smallest alpha-hydroxy acid (AHA). In its pure form, glycolic acid is a colorless crystalline solid. Due to its excellent capability to penetrate skin, glycolic acid finds applications in skin care products, most often as a chemical peel. Glycolic acid is also used for tattoo removal.

# Synonyms:
2-Hydroxyacetate; 2-Hydroxyacetic acid; GlyPure; GlyPure 70; Glycocide; Glycolate; Glycollate; Glycolic acid; Glycollic acid; Hydroxyacetate; Hydroxyacetic acid; Hydroxyethanoate; Hydroxyethanoic acid; a-Hydroxyacetate; a-Hydroxyacetic acid; Sodium glycolate; alpha-Hydroxyacetate; alpha-Hydroxyacetic acid

# Chemical_IUPAC_Name:
Acetic acid, hydroxy-

# Chemical_Formula:
C2H4O3

# Chemical_Structure:
tbl_chemical:::HMDB00115_ZOOM.png:::119283194858559770

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00115_THUMB.png:::119283194720772977

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary alcohol; carboxylic acid; alpha-hydroxyacid

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
76.01605

# Molecular_Weight_Avg:
76.05136

# Smiles_String_isomeric:
OCC(O)=O

# Smiles_String_canonical:
OCC(O)=O

# KEGG_Compound_ID:
C00160

# BioCyc_ID:
GLYCOLLATE

# PubChem_CID:
757

# PubChem_SID:
8145512; 3135611; 3460; 834273; 10324330; 175185; 2774; 831014; 8028465; 589599; 6350; 7989227; 837138; 8150775; 566891; 827351; 10536092; 623904; 149551; 7850238; 67104; 854465; 8137761; 4523739; 841751; 7887947

# OMIM_ID:
259900; 260000

# Metagene_ID:
PRIMARY HYPEROXALURIA I, PH1: 184

# BiGG_ID:
34090

# Wikipedia_ID:
Glycolic acid

# METLIN_ID:
3219

# Ref_ID:
15660917; 2026685; 8634803; 2002628; 11795781; 10595845; 3337119; 8087979; 11359487; 2242313; 14742135; 8311360; 8412012; 1507356; 8651024; 11953504; 9267307; 8634809; 6592775; 11762669

# ChEBI_ID:
29805

# CAS_Registry_Number:
79-14-1

# InChI:
InChI=1/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)

# Synthesis_Reference:
Preparation of glycollic acid.     Witzemann, Edgar J.    Journal of the American Chemical Society  (1917),  39  109-12.

# Melting_Point:
75-80 oC

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
1000.0 mg/mL [MEYLAN,WM et al. (1996)]; 608.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
-1.11 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-1.01 [Predicted by ALOGPS]; -1.1 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Glycolic acid.pdf:::1132562201310626489

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Glycolic_acid.mol:::1132723807937381963

# SDF_File_[Text]:
tbl_chemical:::HMDB00115.sdf:::119283194435366751

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00115.pdb:::119283194582020450

# PDB_ID:
1QKI

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041018_P00_03_HW_1DP_PRESAT_expanded_1.gif:::11416823133639122

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041018_P00_03_HW_1DP_presat.zip:::1177710602240237846

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041018_P00_03_HW_1DP_Assigned.png:::114660660312043723

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041018_P00_03_HW_2DHSQC_649.png:::114798390808795598

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041018_P00_03_HW_2DHSQC_649.zip:::114798390813736650

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041018_P00_03_HW_2DHSQC_649_Assigned.png:::115384174139769520

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Glycolic acid.gif:::1132732109984281000

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00115_peaks.txt:::1156309552377801669

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Glycolic acid_C.gif:::1132737687681275370

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00115_peaks.txt:::1156310742549533187

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00115L.png:::117555262457438978; Medium Energy:tbl_ms:::HMDB00115M.png:::117555267833533362; High Energy:tbl_ms:::HMDB00115H.png:::117555271439055254

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP); mitochondria; peroxisome

# Tissue_Location:
Bladder; Epidermis; Fibroblasts; Liver; Skin; Stratum Corneum

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	32.8	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	8087979
Urine	39.6	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	8087979
Urine	50.0	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	77.1	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	67.9	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	8087979
Urine	38.1 +/- 27.35	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	2026685
Urine	64.0 (21.0-107.0)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9267307
Urine	 248.5(72.0-425.0)	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	2242313
Urine	169.5 (46.0-293.0)	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	2242313
Urine	128.0 (48.0-208.0)	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	2242313
Urine	110.0 (34.0-186.0)	umol/mmol_creatinine	Adolescent:13-18_yrs_old	Both	Normal	2242313
Blood	7.9 +/- 2.4	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	1507356
Blood	7.8 +/- 1.7	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	2002628 
Cerebrospinal_Fluid(CSF)	54.0 +/- 50.0	umol/L	Adult:>18_yrs_old	N/A	Normal	8412012


# Concentration_[Abnormal]:
Urine	23.0 +/- 14.0	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Lung Cancer	HMP experiment
Blood	48.0 (40.0-56.0)	uM	Adult:>18_yrs_old	Both	Ethylene Glycol Poisoning	3337119


# Associated_Disorders:
Ethylene Glycol Poisoning; Hyperoxaluria; Lung Cancer; Primary Hyperoxaluria I (PH1)

# Pathway_Names:
Alanine and aspartate metabolism;Butanoate metabolism;Glycolysis;Fatty acid metabolism;Bile acid biosynthesis;Valine, leucine and isoleucine degradation;Lysine degradation;Glycerolipid metabolism;Pyruvate metabolism;Propanoate metabolism;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
Aspartate_and_Alanine_metabolism.jpg;;Glycolysis.jpg;;;valine,leucine,and_isoleucine_degradation.jpg;Lysine_degradation.jpg;;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00252;map00650;map00010;map00071;map00120;map00280;map00310;map00561;map00620;map00640;map00280;map00280

# Pathway_Graphs:
Aspartate_and_Alanine_metabolism_Graph.jpg;;Glycolysis_Graph.jpg;;;valine,leucine,and_isoleucine_degradation_Graph.jpg;Lysine_degradation_Graph.jpg;;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
Aspartate_and_Alanine_metabolism.xml;;Glycolysis.xml;;;valine,leucine,and_isoleucine_degradation.xml;Lysine_degradation.xml;;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5975

# Metabolic_Enzyme_1_Name:
Glutamate decarboxylase 2

# Metabolic_Enzyme_1_Synonyms:
Glutamate decarboxylase 65 kDa isoform; GAD-65; 65 kDa glutamic acid decarboxylase

# Metabolic_Enzyme_1_Gene_Name:
GAD2

# Metabolic_Enzyme_1_Protein_Sequence:
>Glutamate decarboxylase 2
MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGG
SQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQ
YVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFN
QLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFS
PGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVI
LIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIW
MHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQ
MHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEY
LYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEY
GTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL

# Metabolic_Enzyme_1_Number_of_Residues:
585

# Metabolic_Enzyme_1_Molecular_Weight:
65412

# Metabolic_Enzyme_1_Theoretical_pI:
6.89

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the production of GABA

# Metabolic_Enzyme_1_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00410  beta-Alanine metabolism;
 map00430  Taurine and hypotaurine metabolism;
 map00650  Butanoate metabolism

# Metabolic_Enzyme_1_Reaction:
L-glutamate = 4-aminobutanoate + CO2

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00282:Pyridoxal_deC

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 4.1.1.15

# Metabolic_Enzyme_1_GenBank_ID_Protein:
182934

# Metabolic_Enzyme_1_SwissProt_ID:
DCE2_HUMAN (Q05329)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
GAD2

# Metabolic_Enzyme_1_Geneatlas_id:
GAD2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4093

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm; cytosol. Cytoplasmic vesicle. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters

# Metabolic_Enzyme_1_Gene_Sequence:
>1758 bp
ATGGCATCTCCGGGCTCTGGCTTTTGGTCTTTCGGGTCGGAAGATGGCTCTGGGGATTCC
GAGAATCCCGGCACAGCGCGAGCCTGGTGCCAAGTGGCTCAGAAGTTCACGGGCGGCATC
GGAAACAAACTGTGCGCCCTGCTCTACGGAGACGCCGAGAAGCCGGCGGAGAGCGGCGGG
AGCCAACCCCCGCGGGCCGCCGCCCGGAAGGCCGCCTGCGCCTGCGACCAGAAGCCCTGC
AGCTGCTCCAAAGTGGATGTCAACTACGCGTTTCTCCATGCAACAGACCTGCTGCCGGCG
TGTGATGGAGAAAGGCCCACTTTGGCGTTTCTGCAAGATGTTATGAACATTTTACTTCAG
TATGTGGTGAAAAGTTTCGATAGATCAACCAAAGTGATTGATTTCCATTATCCTAATGAG
CTTCTCCAAGAATATAATTGGGAATTGGCAGACCAACCACAAAATTTGGAGGAAATTTTG
ATGCATTGCCAAACAACTCTAAAATATGCAATTAAAACAGGGCATCCTAGATACTTCAAT
CAACTTTCTACTGGTTTGGATATGGTTGGATTAGCAGCAGACTGGCTGACATCAACAGCA
AATACTAACATGTTCACCTATGAAATTGCTCCAGTATTTGTGCTTTTGGAATATGTCACA
CTAAAGAAAATGAGAGAAATCATTGGCTGGCCAGGGGGCTCTGGCGATGGGATATTTTCT
CCCGGTGGCGCCATATCTAACATGTATGCCATGATGATCGCACGCTTTAAGATGTTCCCA
GAAGTCAAGGAGAAAGGAATGGCTGCTCTTCCCAGGCTCATTGCCTTCACGTCTGAACAT
AGTCATTTTTCTCTCAAGAAGGGAGCTGCAGCCTTAGGGATTGGAACAGACAGCGTGATT
CTGATTAAATGTGATGAGAGAGGGAAAATGATTCCATCTGATCTTGAAAGAAGGATTCTT
GAAGCCAAACAGAAAGGGTTTGTTCCTTTCCTCGTGAGTGCCACAGCTGGAACCACCGTG
TACGGAGCATTTGACCCCCTCTTAGCTGTCGCTGACATTTGCAAAAAGTATAAGATCTGG
ATGCATGTGGATGCAGCTTGGGGTGGGGGATTACTGATGTCCCGAAAACACAAGTGGAAA
CTGAGTGGCGTGGAGAGGGCCAACTCTGTGACGTGGAATCCACACAAGATGATGGGAGTC
CCTTTGCAGTGCTCTGCTCTCCTGGTTAGAGAAGAGGGATTGATGCAGAATTGCAACCAA
ATGCATGCCTCCTACCTCTTTCAGCAAGATAAACATTATGACCTGTCCTATGACACTGGA
GACAAGGCCTTACAGTGCGGACGCCACGTTGATGTTTTTAAACTATGGCTGATGTGGAGG
GCAAAGGGGACTACCGGGTTTGAAGCGCATGTTGATAAATGTTTGGAGTTGGCAGAGTAT
TTATACAACATCATAAAAAACCGAGAAGGATATGAGATGGTGTTTGATGGGAAGCCTCAG
CACACAAATGTCTGCTTCTGGTACATTCCTCCAAGCTTGCGTACTCTGGAAGACAATGAA
GAGAGAATGAGTCGCCTCTCGAAGGTGGCTCCAGTGATTAAAGCCAGAATGATGGAGTAT
GGAACCACAATGGTCAGCTACCAACCCTTGGGAGACAAGGTCAATTTCTTCCGCATGGTC
ATCTCAAACCCAGCGGCAACTCACCAAGACATTGACTTCCTGATTGAAGAAATAGAACGC
CTTGGACAAGATTTATAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M81882

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_1_Locus:
10p11.23

# Metabolic_Enzyme_1_SNPs:
rs2839672; rs2839678; rs1805397; rs2229845; rs7919405; rs1556234; rs3781106; rs8190809; rs1335547; rs3781105; rs3781107; rs8190811; rs8190812; rs8190817; rs8190816; rs8190800; rs8190590; rs8190813; rs8190805; rs8190801; rs7073217; rs8190802; rs8190814; rs8190807; rs8190815; rs8190803; rs992990; rs2368160; rs2368159; rs913963; rs913964; rs1999241; rs870341; rs928197; rs8190604; rs7906725; rs3781109; rs6482551; rs1330581; rs8190764; rs4749108; rs6482541; rs7897510; rs8190780; rs7071922; rs3893052; rs6482537; rs7073119; rs7900739; rs2839671; rs3781108; rs11015008; rs12267286; rs4994426; rs7893400; rs1330582; rs8190754; rs7087663; rs7900976; rs12414701; rs7074534; rs4144102; rs7074235; rs7068224; rs3847380; rs3781113; rs7902107; rs7076544; rs6482540; rs7913676; rs7908975; rs6482550; rs3781117; rs4747548; rs8190748; rs4749105; rs8190706; rs8190704; rs7087011; rs3781114; rs4749101; rs3847378; rs7893194; rs4747550; rs7913524; rs4749102; rs8190798; rs4749107; rs7095327; rs4747547; rs4747549; rs3847379; rs6482538; rs8190598; rs3824694; rs17667367; rs8190658; rs3781111; rs7081084; rs11015015; rs8190694; rs7897355; rs8190734; rs3904297; rs10828963; rs928198; rs913962; rs11015025; rs8190624; rs7099569; rs7918935; rs7072964; rs8190628; rs11015024; rs8190714; rs4749103; rs8190690; rs8190635; rs3781112; rs2839676; rs7909909; rs8190720; rs8190645; rs16926761; rs8190770; rs11594057; rs870342; rs6482544; rs7898281; rs1935996; rs8190708; rs8190716; rs3904298; rs8190597; rs8190779; rs3781116; rs12253114; rs8190660; rs7089304; rs3893253; rs7074934; rs2839675; rs8190796; rs4749104; rs12098763; rs7080514; rs8190685; rs7067571; rs6482543; rs7068510; rs8190611; rs12242971; rs1805398; rs7072137; rs8190689; rs8190646; rs11015010; rs11015028; rs8190718; rs2298124; rs2839674; rs8190713; rs7100268; rs6482548; rs7903208; rs7078680; rs1805399; rs8190678; rs8190701; rs8190612; rs3781118; rs3904296; rs8190637; rs8190683; rs8190673; rs8190782; rs7079102; rs6482542; rs11015004; rs12258601; rs12263667; rs7909902; rs8190620; rs8190650; rs7911425; rs6482547; rs913965; rs8190794; rs8190741; rs8190621; rs7895479; rs1330579; rs8190786; rs8190665; rs8190594; rs8190778; rs8190656; rs16926784; rs8190618; rs8190675; rs8190711; rs8190739; rs7091779; rs8190616; rs8190648; rs8190763; rs8190661; rs11015012; rs8190773; rs12248404; rs8190641; rs8190746; rs8190757; rs8190668; rs12358823; rs8190776; rs8190750; rs8190697; rs11015016; rs7067786; rs8190695; rs8190623; rs12258107; rs6482539; rs8190723; rs8190797; rs8190738; rs8190765; rs8190787; rs7915657; rs7912687; rs12251044; rs10828964; rs8190608; rs8190667; rs8190596; rs16926747; rs8190781; rs8190642; rs8190639; rs8190751; rs8190784; rs8190627; rs3781110; rs8190696; rs8190703; rs12254792; rs8190593; rs8190715; rs8190737; rs8190634; rs8190727; rs10160178; rs12098764; rs8190771; rs8190736; rs8190682; rs2839677; rs8190651; rs8190785; rs11015018; rs4111544; rs7911393; rs10466096; rs7080693; rs11015003; rs8190709; rs7909127; rs7922748; rs8190733; rs11015017; rs8190602; rs8190672; rs8190789; rs3904299; rs8190692; rs8190626; rs8190632; rs8190774; rs11015002; rs12243085; rs8190768; rs8190722; rs8190617; rs7905275; rs8190752; rs8190595; rs8190728; rs1330580; rs7893528; rs11015011; rs12360108; rs8190607; rs8190772; rs8190766; rs8190693; rs8190647; rs7089218; rs6482549; rs10466098; rs8190756; rs8190775; rs8190744; rs7914135; rs12243037; rs12240863; rs8190758; rs8190670; rs7076905; rs12269473; rs8190721; rs8190606; rs8190615; rs8190649; rs2236418; rs3758446; rs4749111; rs8190582; rs2839669; rs2839670; rs4747553; rs4749110; rs7090727; rs4747551; rs7090581; rs4747552; rs2236417; rs8190586; rs1065239; rs8190588; rs8190825; rs8190585; rs8190587; rs8190584; rs8190823; rs2839673; rs8190730; rs8190671; rs8190600; rs8190591; rs8190729; rs8190799; rs8190804; rs34587935; rs41279918; rs8190818; rs1360845; rs8190821; rs17847106; rs8190806; rs8190819; rs8190820; rs8190810; rs8190808; rs2210118; rs35598312; rs35399576; rs8190609; rs8190724; rs11015005; rs11015026; rs8190753; rs8190747; rs11812646; rs11015007; rs8190731; rs16926771; rs34544929; rs8190783; rs8190680; rs8190742; rs7914958; rs11424034; rs34446027; rs10706901; rs8190687; rs8190795; rs8190792; rs12242900; rs7912720; rs12765251; rs8190638; rs17847108; rs35729928; rs35302027; rs8190674; rs28411087; rs36068216; rs11015021; rs12413327; rs41279916; rs8190760; rs3831349; rs35525470; rs8190702; rs12240533; rs8190759; rs7077030; rs35027140; rs8190657; rs8190743; rs35001308; rs35095406; rs8190664; rs35193512; rs8190676; rs7898671; rs34460749; rs7910714; rs8190610; rs8190601; rs11015029; rs34165540; rs10571094; rs34714031; rs17847113; rs8190655; rs10466097; rs8190691; rs34544347; rs8190788; rs34492981; rs11397236; rs8190640; rs8190767; rs34551923; rs11015013; rs12240390; rs17847119; rs958295; rs7896603; rs8190613; rs11351928; rs8190793; rs35560251; rs8190777; rs12258225; rs4749109; rs35466733; rs8190619; rs12764007; rs8190677; rs8190712; rs8190684; rs8190652; rs8190761; rs11015023; rs8190717; rs3925895; rs12780466; rs35967087; rs10691988; rs41279914; rs8190654; rs35473617; rs7906622; rs8190622; rs8190699; rs8190700; rs35554915; rs8190790; rs8190614; rs34282513; rs7904959; rs35460917; rs35692804; rs35701656; rs5783968; rs41304597; rs8190740; rs11015030; rs7910604; rs12258527; rs4749100; rs8190755; rs12265834; rs7906659; rs7911822; rs8190681; rs11382565; rs10550716; rs8190726; rs41304609; rs7900313; rs12258214; rs8190599; rs11015014; rs8190633; rs8190605; rs11594128; rs7084058; rs8190643; rs35046451; rs7897227; rs35449881; rs11015009; rs35322930; rs35856372; rs35871778; rs11389512; rs8190636; rs11437464; rs8190653; rs35327186; rs35218393; rs8190745; rs34436183; rs11015006; rs35900771; rs8190732; rs8190735; rs12252062; rs7074897; rs8190791; rs8190725; rs8190666; rs8190669; rs8190631; rs8190707; rs8190679; rs8190749; rs34964656; rs34166651; rs35778757; rs8190719; rs8190710; rs8190686; rs35829665; rs11407523; rs8190625; rs11417128; rs8190659; rs36008357; rs16926745; rs8190698; rs8190769; rs11014999; rs8190603; rs8190705; rs7078821; rs11015027; rs8190762; rs8190644; rs4589175; rs8190589; rs8190822; rs8190583; rs34861013; rs10508715; rs11014998; rs11015031; rs11015032; rs11591556; rs12248143; rs12256696; rs12264198; rs12265385; rs1330574; rs16926835; rs16926836; rs1888251; rs2150157; rs2150158; rs2150159; rs2150160; rs2839668; rs7899642; rs7915415; rs7922791; rs8190828; rs8190830; rs876845; rs876846; rs876847; rs876848; rs882138; rs994502

# Metabolic_Enzyme_1_General_References:
1924293; 1549570; 8088791; 7680313; 8243826; 8999827; 12356867

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5976

# Metabolic_Enzyme_2_Name:
Glutamate decarboxylase 1

# Metabolic_Enzyme_2_Synonyms:
Glutamate decarboxylase 67 kDa isoform; GAD-67; 67 kDa glutamic acid decarboxylase

# Metabolic_Enzyme_2_Gene_Name:
GAD1

# Metabolic_Enzyme_2_Protein_Sequence:
>Glutamate decarboxylase 1
MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEK
SRLVSAFKERQSSKNLLSCENSDRDARFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEV
VDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGV
RTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWS
SKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTSEQSHYSIKKAGAA
LGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDPIQEIA
DICEKYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKE
KGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQI
NKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAP
KIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL

# Metabolic_Enzyme_2_Number_of_Residues:
594

# Metabolic_Enzyme_2_Molecular_Weight:
66897

# Metabolic_Enzyme_2_Theoretical_pI:
7.67

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the production of GABA

# Metabolic_Enzyme_2_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00410  beta-Alanine metabolism;
 map00430  Taurine and hypotaurine metabolism;
 map00650  Butanoate metabolism

# Metabolic_Enzyme_2_Reaction:
L-glutamate = 4-aminobutanoate + CO2

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00282:Pyridoxal_deC

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 4.1.1.15

# Metabolic_Enzyme_2_GenBank_ID_Protein:
182936

# Metabolic_Enzyme_2_SwissProt_ID:
DCE1_HUMAN (Q99259)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
GAD1

# Metabolic_Enzyme_2_Geneatlas_id:
GAD1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:4092

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>1785 bp
ATGGCGTCTTCGACCCCATCTTCGTCCGCAACCTCCTCGAACGCGGGAGCGGACCCCAAT
ACCACTAACCTGCGCCCCACAACGTACGATACCTGGTGCGGCGTGGCCCATGGATGCACC
AGAAAACTGGGGCTCAAGATCTGCGGCTTCTTGCAAAGGACCAACAGCCTGGAAGAGAAG
AGTCGCCTTGTGAGTGCCTTCAGGGAGAGGCAATCCTCCAAGAACCTGCTTTCCTGTGAA
AACAGCGACCGGGATGCCCGCTTCCGGCGCACAGAGACTGACTTCTCTAATCTGTTTGCT
AGAGATCTGCTTCCGGCTAAGAACGGTGAGGAGCAAACCGTGCAATTCCTCCTGGAAGTG
GTGGACATACTCCTCAACTATGTCCGCAAGACATTTGATCGCTCCACCAAGGTGCTGGAC
TTTCATCACCCACACCAGTTGCTGGAAGGCATGGAGGGCTTCAACTTGGAGCTCTCTGAC
CACCCCGAGTCCCTGGAGCAGATCCTGGTTGACTGCAGAGACACCTTGAAGTATGGGGTT
CGCACAGGTCATCCTCGATTTTTCAACCAGCTCTCCACTGGATTGGATATTATTGGCCTA
GCTGGAGAATGGCTGACATCAACGGCCAATACCAACATGTTTACATATGAAATTGCACCA
GTGTTTGTCCTCATGGAACAAATAACACTTAAGAAGATGAGAGAGATAGTTGGATGGTCA
AGTAAAGATGGTGATGGGATATTTTCTCCTGGGGGCGCCATATCCAACATGTACAGCATC
ATGGCTGCTCGCTACAAGTACTTCCCGGAAGTTAAGACAAAGGGCATGGCGGCTGTGCCT
AAACTGGTCCTCTTCACCTCAGAACAGAGTCACTATTCCATAAAGAAAGCTGGGGCTGCA
CTTGGCTTTGGAACTGACAATGTGATTTTGATAAAGTGCAATGAAAGGGGGAAAATAATT
CCAGCTGATTTTGAGGCAAAAATTCTTGAAGCCAAACAGAAGGGATATGTTCCCTTTTAT
GTCAATGCAACTGCTGGCACGACTGTTTATGGAGCTTTTGATCCGATACAAGAGATTGCA
GATATATGTGAGAAATATAACCTTTGGTTGCATGTCGATGCTGCCTGGGGAGGTGGGCTG
CTCATGTCCAGGAAGCACCGCCATAAACTCAACGGCATAGAAAGGGCCAACTCAGTCACC
TGGAACCCTCACAAGATGATGGGCGTGCTGTTGCAGTGCTCTGCCATTCTCGTCAAGGAA
AAGGGTATACTCCAAGGATGCAACCAGATGTGTGCAGGATATCTCTTCCAGCCAGACAAG
CAGTATGATGTCTCCTACGACACCGGGGACAAGGCAATTCAGTGTGGCCGCCACGTGGAT
ATCTTCAAGTTCTGGCTGATGTGGAAAGCAAAGGGCACAGTGGGATTTGAAAACCAGATC
AACAAATGCCTGGAACTGGCTGAATACCTCTATGCCAAGATTAAAAACAGAGAAGAATTT
GAGATGGTTTTCAATGGCGAGCCTGAGCACACAAACGTCTGTTTTTGGTATATTCCACAA
AGCCTCAGGGGTGTGCCAGACAGCCCTCAACGACGGGAAAAGCTACACAAGGTGGCTCCA
AAAATCAAAGCCCTGATGATGGAGTCAGGTACGACCATGGTTGGCTACCAGCCCCAAGGG
GACAAGGCCAACTTCTTCCGGATGGTCATCTCCAACCCAGCCGCTACCCAGTCTGACATT
GACTTCCTCATTGAGGAGATAGAAAGACTGGGCCAGGATCTGTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M81883

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_2_Locus:
2q31

# Metabolic_Enzyme_2_SNPs:
rs769402; rs769403; rs41526346; rs769401; rs11542313; rs769395; rs2270335; rs769399; rs3749034; rs1049730; rs3762553; rs769406; rs769409; rs2058725; rs769391; rs769411; rs3791861; rs3791856; rs2270334; rs701492; rs4668331; rs3791857; rs769393; rs3791875; rs3791853; rs3791876; rs2302659; rs3791877; rs769390; rs3791862; rs10439259; rs2234728; rs4668329; rs2241164; rs3791860; rs7561581; rs3791850; rs6716794; rs3791865; rs3791858; rs2241165; rs3791851; rs7578661; rs3828275; rs6433253; rs16858977; rs3791866; rs16858988; rs6433252; rs3749033; rs34210682; rs12612498; rs769405; rs3791871; rs4668330; rs11900444; rs11896169; rs769408; rs3791874; rs3791859; rs4668327; rs41464547; rs41393845; rs1420385; rs1548902; rs41496949; rs1477061; rs11896015; rs701491; rs3791864; rs3791872; rs10930441; rs11890416; rs10191129; rs11895404; rs769407; rs3791855; rs2234727; rs11890409; rs3762556; rs3791878; rs6755370; rs3762557; rs3749035; rs3791879; rs6755371; rs3791880; rs2356236; rs3762554; rs4668324; rs872124; rs3762555; rs1049731; rs1049736; rs17857149; rs17857148; rs1049735; rs34856125; rs34100397; rs1049733; rs1049734; rs35426017; rs3049870; rs5836306; rs34510522; rs34365430; rs35367730; rs35542409; rs954947; rs17752543; rs13017667; rs35495756; rs3791868; rs10698625; rs3049892; rs11338558; rs11331088; rs41265947; rs3791852; rs13035478; rs769394; rs35089719; rs13018052; rs3838551; rs34072956; rs2160415; rs769389; rs34265473; rs13385854; rs2160414; rs11338557; rs34462898; rs13014614; rs35050499; rs3791867; rs4668332; rs13017665; rs3828274; rs35232338; rs34347776; rs13000989; rs35659093; rs4668325; rs10698618; rs34528852; rs3791873; rs7602684; rs12995992; rs35050304; rs6753612; rs35212610; rs10179059; rs35492651; rs3838552; rs7576933; rs41304175; rs34884445; rs10529529; rs13028093; rs35845895; rs41315874; rs28514878; rs3749032; rs3791854; rs35445717; rs769398; rs5836308; rs12991140; rs13014984; rs13033900; rs3791869; rs11333718; rs3791863; rs10605864; rs7594314; rs4667661; rs34291719; rs3791870; rs11314645; rs35495071; rs769410; rs4536622; rs10623405; rs35403424; rs4668326; rs3838550; rs10930442; rs3838553; rs35991368; rs4668328; rs13014595; rs7595288; rs11327360; rs35566565; rs35379843; rs41311313; rs5836305; rs1362492; rs4667659; rs3762558; rs4667660; rs6755102; rs6758358; rs33918896; rs34236419; rs10803852; rs10930443; rs11682957; rs11694200; rs11904485; rs12185692; rs12472230; rs12614879; rs12999141; rs13432752; rs16858996; rs17701824; rs1978340; rs2160413; rs2192987; rs28642888; rs3762560; rs3762561; rs4389303; rs4667662; rs4667663; rs6433254; rs6433255; rs6433256; rs6433257; rs6433261; rs6755814; rs7564761; rs7577421

# Metabolic_Enzyme_2_General_References:
1549570; 8088791; 1339255; 8507202; 8507203; 10671565; 2039509; 1697032

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5532

# Metabolic_Enzyme_3_Name:
Aldehyde dehydrogenase X, mitochondrial precursor

# Metabolic_Enzyme_3_Synonyms:
Aldehyde dehydrogenase family 1 member B1; ALDH class 2

# Metabolic_Enzyme_3_Gene_Name:
ALDH1B1

# Metabolic_Enzyme_3_Protein_Sequence:
>Aldehyde dehydrogenase X, mitochondrial precursor
MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT
TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNLLADLVERDRVYLA
SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCG
QIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITG
YGPTAGAAIAQHMDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADM
EHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGP
QVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP
VQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHT
PFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS

# Metabolic_Enzyme_3_Number_of_Residues:
517

# Metabolic_Enzyme_3_Molecular_Weight:
57239

# Metabolic_Enzyme_3_Theoretical_pI:
6.79

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation

# Metabolic_Enzyme_3_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_3_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_3_Signals:
1-22

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1263008

# Metabolic_Enzyme_3_SwissProt_ID:
AL1B1_HUMAN (P30837)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ALDH1B1

# Metabolic_Enzyme_3_Geneatlas_id:
ALDH1B1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:407

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_3_Gene_Sequence:
>1554 bp
ATGCTGCGCTTCCTGGCACCCCGGCTGCTTAGCCTCCAGGGCAGGACCGCCCTCTACTCC
TCGGCAGCAGCCCTCCCAAGCCCCATTCTGAACCCAGACATCCCCTACAACCAGCTGTTC
ATCAACAATGAATGGCAAGATGCAGTCAGCAAGAAGACCTTCCCGACGGTCAACCCTACC
ACCGGGGAGGTCATCGGGCACGTGGCTGAAGGTGACCGGGCTGATGTGGATCGGGCCGTG
AAAGCAGCCCGGGAAGCCTTCCGCCTGGGGTCCCCATGGCGCCGGATGGATGCCTCTGAG
CGGGGCCGGCTGCTGAACCTCCTGGCAGACCTAGTGGAGCGGGATCGAGTCTACTTGGCC
TCACTCGAGACCTTGGACAATGGGAAGCCTTTCCAAGAGTCTTACGCCTTGGACTTGGAT
GAGGTCATCAAGGTGTATCGGTACTTTGCTGGCTGGGCTGACAAGTGGCATGGCAAGACC
ATCCCCATGCATGGCCAGCATTTCTGCTTCACCCGGCATGAGCCCGTTGGTGTCTGTGGC
CAGATCATCCCGTGGAACTTCCCCTTGGTCATGCAGGGTTGGAAACTTGCCCCGGCACTC
GCCACAGGCAACACTGTGGTTATGAAGGTGGCAGAGCAGACCCCCCTCTCTGCCCTGTAT
TTGGCCTCCCTCATCAAGGAGGCAGGCTTTCCCCCTGGGGTGGTGAACATCATCACGGGG
TATGGCCCAACAGCAGGTGCGGCCATCGCCCAGCACATGGATGTTGACAAAGTTGCCTTC
ACCGGTTCCACCGAGGTGGGCCACCTGATCCAGAAAGCAGCTGGCGATTCCAACCTCAAG
AGAGTCACCCTGGAGCTGGGTGGTAAGAGCCCCAGCATCGTGCTGGCCGATGCTGACATG
GAGCATGCCGTGGAGCAGTGCCACGAAGCCCTGTTCTTCAACATGGGCCAGTGCTGCTGT
GCTGGCTCCCGGACCTTCGTGGAAGAATCCATCTACAATGAGTTTCTCGAGAGAACCGTG
GAGAAAGCAAAGCAGAGGAAAGTGGGGAACCCCTTTGAGCTGGACACCCAGCAGGGGCCT
CAGGTGGACAAGGAGCAGTTTGAACGAGTCCTAGGCTACATCCAGCTTGGCCAGAAGGAG
GGCGCAAAACTCCTCTGTGGCGGAGAGCGTTTCGGGGAGCGTGGTTTCTTCATCAAGCCT
ACTGTCTTTGGTGGCGTGCAGGATGACATGAGAATTGCCAAAGAGGAGATCTTTGGGCCT
GTGCAGCCCCTGTTCAAGTTCAAGAAGATTGAGGAGGTGGTTGAGAGGGCCAACAACACC
AGGTATGGCCTGGCTGCGGCTGTGTTCACCCGGGATCTGGACAAGGCCATGTACTTCACC
CAGGCACTCCAGGCCGGGACCGTGTGGGTAAACACCTACAACATCGTCACCTGCCACACG
CCATTTGGAGGGTTTAAGGAATCTGGAAACGGGAGGGAGCTGGGTGAGGATGGGCTTAAG
GCCTACACAGAGGTAAAGACGGTCACCATCAAGGTTCCTCAGAAGAACTCGTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M63967

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_3_Locus:
9p11.1

# Metabolic_Enzyme_3_SNPs:
rs2228093; rs4878199; rs2073478; rs2073477; rs2228094; rs3043; rs6476701; rs10758494; rs10758495; rs7859877; rs4646772; rs4646774; rs4878802; rs10738997; rs11555705; rs4646773; rs41278335; rs11555706; rs10973781; rs10973782; rs12343271; rs41278337; rs10118683; rs10758496; rs10814687; rs10973774; rs10973779; rs10973783; rs10973785; rs10973786; rs10973787; rs10973789; rs10973792; rs11361; rs11790480; rs11791018; rs11791622; rs12001093; rs12336048; rs12352007; rs12378762; rs13285234; rs13290293; rs1555480; rs1923423; rs1923424; rs2038589; rs34183602; rs35950473; rs4142260; rs4242647; rs4878203; rs4878800; rs4878801; rs4878804; rs4878805; rs4878806; rs4878807; rs4878808; rs4878809; rs4878811; rs6476703; rs7021469; rs7031628; rs7045542; rs7046137; rs7853954; rs7865905; rs7866277; rs7867383; rs911757; rs911758

# Metabolic_Enzyme_3_General_References:
2061311; 8244338

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5702

# Metabolic_Enzyme_4_Name:
Glycine amidinotransferase, mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
L- arginine:glycine amidinotransferase; Transamidinase; AT

# Metabolic_Enzyme_4_Gene_Name:
GATM

# Metabolic_Enzyme_4_Protein_Sequence:
>Glycine amidinotransferase, mitochondrial precursor
MLRVRCLRGGSRGAEAVHYIGSRLGRTLTGWVQRTFQSTQAATASSRNSCAADDKATEPL
PKDCPVSSYNEWDPLEEVIVGRAENACVPPFTIEVKANTYEKYWPFYQKQGGHYFPKDHL
KKAVAEIEEMCNILKTEGVTVRRPDPIDWSLKYKTPDFESTGLYSAMPRDILIVVGNEII
EAPMAWRSRFFEYRAYRSIIKDYFHRGAKWTTAPKPTMADELYNQDYPIHSVEDRHKLAA
QGKFVTTEFEPCFDAADFIRAGRDIFAQRSQVTNYLGIEWMRRHLAPDYRVHIISFKDPN
PMHIDATFNIIGPGIVLSNPDRPCHQIDLFKKAGWTIITPPTPIIPDDHPLWMSSKWLSM
NVLMLDEKRVMVDANEVPIQKMFEKLGITTIKVNIRNANSLGGGFHCWTCDVRRRGTLQS
YLD

# Metabolic_Enzyme_4_Number_of_Residues:
423

# Metabolic_Enzyme_4_Molecular_Weight:
48456

# Metabolic_Enzyme_4_Theoretical_pI:
8.15

# Metabolic_Enzyme_4_GO_Classification:
Not Available

# Metabolic_Enzyme_4_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
L-arginine + glycine = L-ornithine + guanidinoacetate

# Metabolic_Enzyme_4_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_4_Reaction:
L-arginine + glycine = L-ornithine + guanidinoacetate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF02274:Amidinotransf

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.1.4.1

# Metabolic_Enzyme_4_GenBank_ID_Protein:
545385

# Metabolic_Enzyme_4_SwissProt_ID:
GATM_HUMAN (P50440)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
GATM

# Metabolic_Enzyme_4_Geneatlas_id:
GATM

# Metabolic_Enzyme_4_hgnc_id:
HGNC:4175

# Metabolic_Enzyme_4_PDB_ID:
3JDW

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane; intermembrane side (Potential). Cytoplasm. Note=The mitochondrial form is found in the intermembrane space probably attached to the outer side of the inner membrane

# Metabolic_Enzyme_4_Gene_Sequence:
>1272 bp
ATGCTGCGGGTGCGGTGTCTGCGCGGCGGGAGCCGCGGCGCCGAGGCGGTGCACTACATC
GGATCTCGGCTTGGACGAACCTTGACAGGATGGGTGCAGCGAACTTTCCAGAGCACCCAG
GCAGCTACGGCTTCCTCCCGGAACTCCTGTGCAGCTGACGACAAAGCCACTGAGCCTCTG
CCCAAGGACTGCCCTGTCTCTTCTTACAACGAATGGGACCCCTTAGAGGAAGTGATAGTG
GGCAGAGCAGAAAACGCCTGTGTTCCACCGTTCACCATCGAGGTGAAGGCCAACACATAT
GAAAAGTACTGGCCATTTTACCAGAAGCAAGGAGGGCATTATTTTCCCAAAGATCATTTG
AAAAAGGCTGTTGCTGAAATTGAAGAAATGTGCAATATTTTAAAAACGGAAGGAGTGACA
GTAAGGAGGCCTGACCCCATTGACTGGTCATTGAAGTATAAAACTCCTGATTTTGAGTCT
ACGGGTTTATACAGTGCAATGCCTCGAGACATCCTGATAGTTGTGGGCAATGAGATTATC
GAGGCTCCCATGGCATGGCGTTCACGCTTCTTTGAGTACCGAGCGTACAGGTCAATTATC
AAAGACTACTTCCACCGTGGCGCCAAGTGGACAACAGCTCCTAAGCCCACAATGGCTGAT
GAGCTTTATAACCAGGATTATCCCATCCACTCTGTAGAAGACAGACACAAATTGGCTGCT
CAGGGAAAATTTGTGACAACTGAGTTTGAGCCATGCTTTGATGCTGCTGACTTCATTCGA
GCTGGAAGAGATATTTTTGCACAGAGAAGCCAGGTTACAAACTACCTAGGCATTGAATGG
ATGCGTAGGCATCTTGCTCCAGACTACAGAGTGCATATCATCTCCTTTAAAGATCCCAAT
CCCATGCATATTGATGCTACCTTCAACATCATTGGACCTGGTATTGTGCTTTCCAACCCT
GACCGACCATGTCACCAGATTGATCTTTTCAAGAAAGCAGGATGGACTATCATTACTCCT
CCAACACCAATCATCCCAGACGATCATCCACTCTGGATGTCATCCAAATGGCTTTCCATG
AATGTCTTAATGCTAGATGAAAAACGTGTTATGGTGGATGCCAATGAAGTTCCAATTCAA
AAGATGTTTGAAAAGCTGGGTATCACTACCATTAAAGTTAACATTCGTAATGCCAATTCC
CTGGGAGGAGGCTTCCATTGCTGGACCTGCGATGTCCGGCGCCGAGGCACCCTACAGTCC
TACTTGGACTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
S68805

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_4_Locus:
15q21.1

# Metabolic_Enzyme_4_SNPs:
rs1288775; rs1145086; rs3210028; rs1145080; rs1145077; rs1145081; rs1049508; rs4775937; rs1049518; rs12441971; rs8024550; rs7164602; rs1145079; rs11070454; rs1049503; rs1145084; rs1145078; rs1346268; rs17618637; rs12442696; rs16942568; rs12442078; rs16942588; rs1554521; rs2486274; rs3759899; rs1145085; rs12437887; rs1153854; rs1153855; rs12594857; rs12437840; rs2433611; rs10519022; rs9972498; rs2172874; rs7494956; rs1055395; rs17535381; rs1890565; rs1153857; rs8040380; rs12595087; rs2114501; rs17618783; rs1153856; rs1145076; rs1153858; rs1145089; rs4271549; rs4395020; rs4627277; rs4774579; rs4625670; rs8038342; rs4534782; rs12439575; rs4774580; rs9788780; rs16942663; rs34991226; rs1049491; rs3210030; rs3210027; rs3210026; rs3210029; rs3210025; rs16942529; rs1145083; rs11070455; rs9672959; rs12439919; rs35353298; rs1145082; rs36091209; rs2486273; rs1145087; rs28395435; rs1691665; rs11853955; rs34835251; rs16942536; rs2486272; rs28609657; rs34215740; rs35805543; rs34690026; rs2467850; rs7164139; rs34122808; rs11275645; rs2467851; rs1049511; rs35410548; rs1593621; rs34755569; rs1049502; rs11281225; rs34245967; rs1153853; rs6145546; rs28711439; rs2453543; rs36108646; rs9806260; rs2453542; rs12324848; rs35634173; rs34202663; rs35160985; rs12595153; rs5812296; rs35727417; rs11283178; rs9972528; rs2486275; rs9972405; rs3047502; rs5812295; rs35698201; rs28681101; rs28552543; rs3047503; rs34418487; rs34271244; rs11310088; rs34401164; rs10152697; rs10444821; rs11070453; rs11070456; rs11070457; rs1145090; rs1145091; rs1145093; rs1145094; rs1153851; rs1153859; rs1346267; rs1426932; rs2056493; rs2056494; rs2066090; rs2217121; rs2433604; rs2433608; rs2433609; rs2433610; rs2461702; rs2461704; rs2467862; rs2486271; rs4774577; rs4775911; rs7163751; rs7174251; rs8032904

# Metabolic_Enzyme_4_General_References:
8313955; 9148748; 9165070; 9218780; 9915841

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5480

# Metabolic_Enzyme_5_Name:
4-aminobutyrate aminotransferase, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
(S-3-amino-2-methylpropionate transaminase; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA aminotransferase; GABA-AT; GABA-T; L-AIBAT

# Metabolic_Enzyme_5_Gene_Name:
ABAT

# Metabolic_Enzyme_5_Protein_Sequence:
>4aminobutyrate aminotransferase, mitochondrial precursor
MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMK
QLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQ
NASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYR
SKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPS
FDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGG
DNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMM
TGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLL
DLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVF
RDHHAHLFLNIFSDILADFK

# Metabolic_Enzyme_5_Number_of_Residues:
500

# Metabolic_Enzyme_5_Molecular_Weight:
56440

# Metabolic_Enzyme_5_Theoretical_pI:
8.04

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  4-aminobutyrate transaminase activity
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid derivative metabolism
Process:  gamma-aminobutyric acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine

# Metabolic_Enzyme_5_Pathway:
map00280  Valine, leucine and isoleucine degradation;
GENES       ECO: b2662(gabT);
            ECJ: JW2637(gabT);
            ECE: Z3960(gabT);
            ECS: ECs3523;
            ECC: c3210(gabT);
            STY: STY2912(gabT);
            STT: t2687(gabT);
            SPT: SPA2649(gabT);
            SEC: SC2724(gabT);
            STM: STM2792(gabT);
            YPE: YPO2844(goaG);
            YPK: y1390(goaG);
            YPM: YP2711(goaG);
            YPS: YPTB2810(goaG);
            SFL: SF2689(gabT);
            SFX: S2874(gabT);
            ECA: ECA2053(gabT);
            PLU: plu2347(goaG);
            VPA: VP1771;
            PAE: PA0266(gabT);
            PPU: PP0214(gabT);
            PST: PSPTO0301(gabT-2);
            PSB: Psyr_0090;
            ACI: ACIAD3446(gabT);
            SON: SO1276(gabT);
            CVI: CV3926(goaG);
            RSO: RSc0029(goaG);
            BMA: BMAA1480(gabT);
            BPS: BPSS0281(gabT);
            BPE: BP2298;
            BPA: BPP2431;
            BBR: BB1880;
            MLO: mlr5521;
            SME: SMb21186(gabT);
            RPA: RPA2323(goaT);
            SIL: SPOA0274(gabT);
            BAN: BA0325(gabT);
            BAR: GBAA0325(gabT);
            BAA: BA_0895;
            BAT: BAS0310;
            BCA: BCE0354(gabT);
            BCZ: BCZK0297(gabT)

# Metabolic_Enzyme_5_Reaction:
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00202:Aminotran_3

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.6.1.19;EC 2.6.1.22

# Metabolic_Enzyme_5_GenBank_ID_Protein:
602705

# Metabolic_Enzyme_5_SwissProt_ID:
GABT_HUMAN (P80404)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ABAT

# Metabolic_Enzyme_5_Geneatlas_id:
ABAT

# Metabolic_Enzyme_5_hgnc_id:
HGNC:23

# Metabolic_Enzyme_5_PDB_ID:
1OHY

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_5_Gene_Sequence:
>1503 bp
ATGGCCTCCATGTTGCTCGCCCAGCGGCTGGCCTGCAGCTTCCAGCACACGTACCGCCTG
CTGGTGCCTGGATCCAGACACATTAGTCAAGCTGCAGCCAAAGTCGACGTTGAATTTGAT
TATGATGGGCCTCTGATGAAGACGGAAGTCCCAGGGCCTAGATCTCAGGAGTTAATGAAA
CAGCTGAATATAATTCAGAATGCAGAGGCTGTGCATTTTTTCTGCAATTACGAAGAGAGC
CGAGGCAATTACCTGGTTGATGTGGACGGCAACCGAATGCTGGATCTTTATTCCCAGATC
TCCTCTGTTCCCATAGGTTACAGCGACCCGGCCCTCGTGAAACTCATCCAACAGCCACAA
AATGCGAGCATGTTTGTCAACAGACCCGCCCTCGAAATCCTGCCTCCGGAGAACTTTGTG
GAGAAGCTCCGGCAGTCCTTGCTCTCGGTGGCTCCCAAAGGGATGTCCCAGCTCATCACC
ATGGCCTGCGGCTCCTGCTCCAATGAAAACGCCTTAAAGACCATCTTCATGTGGTACCGG
AGCAAGGAAAGAGGGCAGAGGGGATTCTCCAAAGAGGAGCTGGAGACGTGCATGATTAAC
CAGGCCCCCTGGTGCCCCGACTACAGCATCCTCTCCTTCATGGGTTCCTTCCATGGGAGG
ACCATGGGTTGCTTAGCGACCACGCACTCTAAAGCCATTCACAAGATCGATATCCCTTCC
TTTGACTGGCCCATCGCACCGTTCCCACGGCTGAAATACCCTCTGGAAGAGTTTGTGAAA
GAGAACCAACAGGAAGAGGCCGGCTGTCTGGAAGAGGTTGAGGATCTGATTGTGAAATAT
CGAAAAAAGAAGAAGACGGTGGCCGGGATCATCGTGGAGCCCATCCAGTCCGAGGGTGGA
GACAACCATGCATCCGATGACTTCTTTCGGAAGCTGAGAGACATCGCCAGGAAGCACTGC
TGCGCCTTCTTGGTGGACGAGGTCCAGACCGGAGGAGGCTGCACGGGCAAGTTCTGGGCC
CATGAGCACTGGGGCCTGGATGACCCAGCAGACGTGATGACCTTCAGCAAGAAGATGATG
ACTGGGGGCTTCTTCCTCAAGGAGGAGTTCAGGCCTAATGCTCCCTACCGGATCTTCAAC
ACGTGGCTGGGGGACCCGTCCAAGAACCTGTTGCTGGCTGAGGTCATCAACATCATCAAG
CGGGAGGACCTGCTAAATAATGCAGCCCATGCCGGGAAGGCCCTGCTCACAGGACTGCTG
GACCTCCAGGCCCGGTACCCCCAGTTCATCAGCAGGGTGAGAGGACGAGGCACCTTTTGC
TCCTTCGATACTCCCGATGATTCCATACGGAATAAGCTCATTTTAATTGCCAGAAACAAA
GGTGTGGTGTTGGGTGGCTGTGGTGACAAATCCATTCGTTTCCGTCCCACGCTGGTGTTC
AGGGATCACCACGCTCACCTGTTCCTCAATATTTTCAGTGACATCTTAGCAGACTTCAAG
TAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
L32961

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_5_Locus:
16p13.2

# Metabolic_Enzyme_5_SNPs:
rs1731017; rs1641022; rs28687443; rs1731062; rs1006636; rs747329; rs1730951; rs1273350; rs1273394; rs1730948; rs4454975; rs3743801; rs1730946; rs6497519; rs1730941; rs2313427; rs1641113; rs1273364; rs4984996; rs1641107; rs747330; rs1273396; rs11075408; rs6497548; rs1730945; rs6497583; rs1295741; rs1641112; rs1273373; rs1640989; rs1273357; rs4985113; rs8062395; rs1730952; rs7205816; rs1641032; rs3108684; rs1730954; rs1273393; rs7199025; rs4985114; rs4985036; rs1730958; rs9935902; rs1641110; rs6497327; rs4985000; rs1273351; rs8055836; rs1641108; rs1344476; rs1730938; rs1730953; rs1730943; rs1641111; rs1730937; rs4984997; rs17566580; rs737695; rs3095512; rs1289964; rs1273360; rs1273397; rs9456; rs1273381; rs1273359; rs1731071; rs1273353; rs1640997; rs3743798; rs1273355; rs9935408; rs6498753; rs17674530; rs1273356; rs12933164; rs1273376; rs1730956; rs1273361; rs1273390; rs12447371; rs12596289; rs1731083; rs1641031; rs12445987; rs12597124; rs4445904; rs11648372; rs1640995; rs1730961; rs1273395; rs11645254; rs9935422; rs1295740; rs11647162; rs4984998; rs11646372; rs1273366; rs1640979; rs7499026; rs2313548; rs6498755; rs1640980; rs3095514; rs1273372; rs1273363; rs6497565; rs11074405; rs1273358; rs1731061; rs1273382; rs1730955; rs1273352; rs1273367; rs7499025; rs1640971; rs7201586; rs1730949; rs1640974; rs1641106; rs8052707; rs1612155; rs1273391; rs12596654; rs12448579; rs1641109; rs1807439; rs8056063; rs1273349; rs1731081; rs1731082; rs9923953; rs8059639; rs3095516; rs1730944; rs11642785; rs8061555; rs1061842; rs1641105; rs8056550; rs12149040; rs1731078; rs7194430; rs1730959; rs1420082; rs12448693; rs12597484; rs737696; rs1273380; rs1273370; rs8058062; rs1640973; rs1731069; rs1730947; rs1731085; rs1731079; rs2270289; rs3095515; rs1640978; rs1640981; rs1730962; rs1640996; rs9939980; rs1123891; rs8054014; rs1273369; rs1730957; rs9928478; rs8046210; rs12921061; rs2270288; rs7501036; rs11648678; rs1273383; rs1273362; rs11643667; rs1730939; rs1881828; rs1640988; rs2313596; rs12444390; rs1731080; rs17651562; rs16964282; rs9935013; rs7193087; rs11866675; rs8275; rs10261; rs12445958; rs1731070; rs737694; rs8048045; rs7192026; rs7197787; rs8050233; rs1640994; rs3095513; rs8049263; rs12447028; rs11643578; rs3095510; rs1641021; rs9674265; rs8057362; rs1273427; rs1641024; rs1273398; rs1273422; rs1273424; rs2091634; rs7196462; rs1273430; rs1640998; rs8053509; rs8049072; rs9673595; rs12708689; rs4985035; rs1641003; rs1641019; rs6497960; rs7197673; rs1273425; rs12447235; rs1273429; rs8055880; rs1641025; rs1273433; rs3815507; rs1079350; rs4482281; rs11863437; rs1273423; rs1731039; rs1731019; rs1640999; rs1641007; rs12446980; rs12925086; rs13337024; rs13336159; rs9937726; rs933481; rs1273431; rs1641014; rs12446169; rs8060255; rs1641002; rs1078509; rs1273417; rs1641027; rs1641016; rs1731027; rs12448959; rs6497959; rs1273428; rs1079348; rs11862060; rs11074631; rs2103340; rs753071; rs1731026; rs1731072; rs1299926; rs1273420; rs8055737; rs12448823; rs1079349; rs1731086; rs7203297; rs1273406; rs3815508; rs1641001; rs8061093; rs9937937; rs9302405; rs11640989; rs8056083; rs11866199; rs1273426; rs9924807; rs1273419; rs1273402; rs1641030; rs7206830; rs1273421; rs8053030; rs12596790; rs8046201; rs11865147; rs1731087; rs1731073; rs13338443; rs1273415; rs12918897; rs1641010; rs8055927; rs11074534; rs13335330; rs1731030; rs1641015; rs9929124; rs10775278; rs1641023; rs1420084; rs9673228; rs7193333; rs1990574; rs1894861; rs1965648; rs1078511; rs1731020; rs1641008; rs1731034; rs1273407; rs1612383; rs11647952; rs2464048; rs1731018; rs9673371; rs7193305; rs1641011; rs1273416; rs1273400; rs11074713; rs1641029; rs9673409; rs1465319; rs1965649; rs1420085; rs10775279; rs11860865; rs12445730; rs11641035; rs1273408; rs7200886; rs1630164; rs13332999; rs1731029; rs1273401; rs1616856; rs1273412; rs1273418; rs12445609; rs11074695; rs8057162; rs13336186; rs11074533; rs1075853; rs1273413; rs11074712; rs3217123; rs9673401; rs1641026; rs12922831; rs12445687; rs13332215; rs12102631; rs12598074; rs12444233; rs1731036; rs1641006; rs12930556; rs12325344; rs933482; rs13339338; rs1613314; rs1965647; rs8061716; rs4989413; rs2302608; rs1641013; rs8048375; rs1617601; rs12448478; rs1273410; rs1465318; rs8060512; rs1641017; rs12149331; rs13331042; rs8047293; rs4984999; rs11646271; rs10852271; rs9925620; rs10775277; rs8060323; rs9931017; rs1420083; rs7203550; rs1641104; rs1139523; rs1139520; rs35780038; rs41311264; rs1139522; rs1062593; rs1139525; rs34813662; rs1042495; rs1139521; rs1139519; rs8059762; rs35850996; rs1273386; rs1640972; rs34187437; rs12597184; rs28415910; rs7195521; rs36138946; rs28587720; rs1640985; rs12149146; rs1731059; rs34441266; rs28403171; rs9939846; rs1640993; rs1273377; rs34595424; rs35454761; rs1273378; rs7195079; rs35916063; rs1640987; rs1273371; rs9928667; rs4296259; rs13334372; rs28382303; rs35255805; rs33951087; rs1630895; rs1731084; rs1273388; rs16964376; rs34014796; rs35351214; rs1730950; rs7184890; rs34724138; rs1640977; rs4442807; rs1731064; rs17651173; rs7204053; rs1273374; rs1730960; rs2178371; rs1640975; rs3095511; rs2160182; rs13337410; rs35163930; rs28692588; rs8056066; rs34165726; rs1731075; rs35012807; rs35638621; rs1640986; rs5815494; rs28602865; rs1273368; rs1640992; rs28622536; rs1731058; rs12149145; rs7190843; rs28714127; rs35832558; rs8056594; rs1986108; rs33928355; rs1640984; rs34006471; rs8060892; rs28742255; rs9746220; rs12926736; rs35163795; rs1273365; rs34531177; rs3065947; rs1640991; rs34595884; rs34089650; rs35176944; rs34736230; rs2313428; rs10163233; rs1731057; rs8049522; rs730750; rs34452392; rs9941133; rs34403235; rs34698480; rs1640970; rs34686381; rs8056020; rs7196194; rs35069718; rs28581915; rs28589960; rs8046394; rs34733640; rs1640983; rs12446703; rs13337518; rs28609006; rs1730942; rs1731076; rs7187850; rs35596444; rs8046003; rs28864687; rs1640990; rs12325121; rs8046571; rs9931939; rs8044285; rs7203755; rs41312250; rs8062725; rs28618356; rs13338663; rs7195524; rs28650912; rs35853974; rs34216922; rs13333072; rs10163342; rs12925473; rs1273379; rs7499024; rs1273387; rs5815492; rs13338551; rs7498949; rs34887951; rs28397834; rs7196287; rs28568507; rs2052235; rs34327953; rs34516341; rs28679855; rs35724649; rs11861413; rs7206673; rs2160181; rs1627524; rs35141742; rs1731077; rs1641114; rs13336886; rs12149463; rs35336676; rs34655579; rs9934284; rs35896679; rs1730940; rs8046260; rs1273375; rs28430948; rs3069301; rs35773832; rs28483683; rs5815493; rs11642744; rs8052663; rs1273389; rs12445001; rs35804023; rs35621836; rs1273392; rs3108683; rs34943374; rs1640982; rs35771183; rs4985115; rs1640976; rs1731088; rs12932819; rs35772192; rs34403809; rs34264472; rs9931477; rs8063475; rs1731024; rs11862275; rs36095894; rs753070; rs1273403; rs1298679; rs1630161; rs34085775; rs28785577; rs7192987; rs33948976; rs13337697; rs3069345; rs12924611; rs1731068; rs1465317; rs13339388; rs28557212; rs34198010; rs6497761; rs7188839; rs13337020; rs12921235; rs28669991; rs12598010; rs1078510; rs1320812; rs35617486; rs13338915; rs12445356; rs9674283; rs36191361; rs1273404; rs11647647; rs34543657; rs7198302; rs12924829; rs34544015; rs36181426; rs1627098; rs1731038; rs9923086; rs1273411; rs36055711; rs10153069; rs1641004; rs1731033; rs1657081; rs35468187; rs13337062; rs7200508; rs7185579; rs35255659; rs11649570; rs34994165; rs35503372; rs12598506; rs1641018; rs1731037; rs34598069; rs34415556; rs41307917; rs11648982; rs34761392; rs1273405; rs1548863; rs1641000; rs34630251; rs2464049; rs28568366; rs12930438; rs7205552; rs1299925; rs9941328; rs28759346; rs34495251; rs1641012; rs34900184; rs1629364; rs11862270; rs9936820; rs9926653; rs34177196; rs41312254; rs7200724; rs9932833; rs35002036; rs12935717; rs28852097; rs1273409; rs35359682; rs753072; rs10852270; rs28427346; rs35691630; rs11640314; rs10775276; rs1731025; rs28495577; rs34651404; rs34982194; rs35248639; rs36034133; rs1078508; rs12149630; rs35745596; rs9926200; rs36000891; rs7187363; rs8060324; rs7189861; rs13339115; rs35414822; rs34346487; rs35585805; rs41303767; rs35010946; rs933480; rs12447747; rs41305755; rs35405936; rs28630033; rs9941032; rs41427146; rs9922301; rs7191001; rs2313560; rs41312252; rs41311266; rs13338171; rs13339497; rs1641005; rs34408519; rs13380503; rs34755382; rs7500881; rs13335619; rs1273432; rs9936647; rs35893143; rs1273414; rs34060423; rs1623647; rs34484640; rs11647644; rs35548548; rs28398424; rs1730964; rs35258023; rs1730963; rs35440533; rs28758216; rs1060784; rs11641192; rs11860988; rs11861249; rs12103329; rs12444391; rs12444975; rs12447079; rs1273384; rs1273385; rs12929416; rs13338256; rs1345300; rs1358692; rs1641098; rs1641099; rs1641100; rs1641101; rs1865805; rs1865806; rs2160180; rs2241103; rs2312957; rs2840195; rs34611261; rs35851221; rs3743811; rs3743812; rs4985110; rs4985111; rs7188782; rs7192702; rs7200823; rs7204765; rs7205295; rs876945; rs9928906

# Metabolic_Enzyme_5_General_References:
7721088; 7851425; 10407778

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5530

# Metabolic_Enzyme_6_Name:
Aldehyde dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_6_Synonyms:
ALDH class 2; ALDHI; ALDH-E2

# Metabolic_Enzyme_6_Gene_Name:
ALDH2

# Metabolic_Enzyme_6_Protein_Sequence:
>Aldehyde dehydrogenase, mitochondrial precursor
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS

# Metabolic_Enzyme_6_Number_of_Residues:
517

# Metabolic_Enzyme_6_Molecular_Weight:
56382

# Metabolic_Enzyme_6_Theoretical_pI:
7.05

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_6_Specific_Function:
An aldehyde + NAD(+) + H(2)O = an acid + NADH

# Metabolic_Enzyme_6_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_6_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_6_Signals:
1-24

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_6_GenBank_ID_Protein:
28606

# Metabolic_Enzyme_6_SwissProt_ID:
ALDH2_HUMAN (P05091)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ALDH2

# Metabolic_Enzyme_6_Geneatlas_id:
ALDH2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:404

# Metabolic_Enzyme_6_PDB_ID:
1OF7

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_6_Gene_Sequence:
>1551 bp
ATGTTGCGCGCTGCCGCCGCTCGGGCCCCGCCTGGCCGCCGCCTCTTGTCAGCCGCCGCC
ACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTTCATA
AACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACT
GGAGAGGTCATCTGTCAGGTAGCTGAAGGGGACAAGGAAGATGTGGACAAGGCACGTGAA
GGCCGCCCGGGCGCCTTCCAGCTGGGCTCACCTTGGCGCCGCATGGACGCATCACACAGC
GGCCGGCTGCTGAACCGCCTGGCCGATCTGATCGAGCGGGACCGGACCTACCTGGCGGCC
TTGGAGACCCTGGACAATGGCAAGCCCTATGTCATCTCCTACCTGGTGGATTTGGACATG
GTCCTCAAATGTCTCCGGTATTATGCCGGCTGGGCTGATAAGTACCACGGGAAAACCATC
CCCATTGACGGAGACTTCTTCAGCTACACACGCCATGAACCTGTGGGGGTGTGCGGGCAG
ATCATTCCGTGGAATTTCCCGCTCCTGATGCAAGCATGGAAGCTGGGCCCAGCCTTGGCA
ACTGGAAACGTGGTTGTGATGAAGGTAGCTGAGCAGACACCCCTCACCGCCCTCTATGTG
GCCAACCTGATCAAGGAGGCTGGCTTTCCCCCTGGTGTGGTCAACATTGTGCCTGGATTT
GGCCCCACGGCTGGGGCCGCCATTGCCTCCCATGAGGATGTGGACAAAGTGGCATTCACA
GGCTCCACTGAGATTGGCCGCGTAATCCAGGTTGCTGCTGGGAGCAGCAACCTCAAGAGA
GTGACCTTGGAGCTGGGGGGGAAGAGCCCCAACATCATCATGTCAGATGCCGATATGGAT
TGGGCCGTGGAACAGGCCCACTTCGCCCTGTTCTTCAACCAGGGCCAGTGCTGCTGTGCC
GGCTCCCGGACCTTCGTGCAGGAGGACATCTATGATGAGTTTGTGGTGCGGAGCGTTGCC
CGGGCCAAGTCTCGGGTGGTCGGGAACCCCTTTGATAGCAAGACCGAGCAGGGGCCGCAG
GTGGATGAAACTCAGTTTAAGAAGATCCTCGGCTACATCAACACGGGGAAGCAAGAGGGG
GCGAAGCTGCTGTGTGGTGGGGGCATTGCTGCTGACCGTGGTTACTTCATCCAGCCCACT
GTGTTTGGAGATGTGCAGGATGGCATGACCATCGCCAAGGAGGAGATCTTCGGGCCAGTG
ATGCAGATCCTGAAGTTCAAGACCATAGAGGAGGTTGTTGGGAGAGCCAACAATTCCACG
TACGGGCTGGCCGCAGCTGTCTTCACAAAGGATTTGGACAAGGCCAATTACCTGTCCCAG
GCCCTCCAGGCGGGCACTGTGTGGGTCAACTGCTATGATGTGTTTGGAGCCCAGTCACCC
TTTGGTGGCTACAAGATGTCGGGGAGTGGCCGGGAGTTGGGCGAGTACGGGCTGCAGGCA
TACACTGAAGTGAAAACTGTCACAGTCAAAGTGCCTCAGAAGAACTCATAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
X05409

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_6_Locus:
12q24.2

# Metabolic_Enzyme_6_SNPs:
rs671; rs1062136; rs6490301; rs886205; rs2238151; rs968529; rs7296651; rs441; rs4767939; rs10744777; rs4646778; rs4767944; rs10849970; rs2158029; rs4646776; rs7312055; rs7311852; rs2238152; rs4646777; rs2283354; rs10774637; rs4648328; rs10774638; rs11609628; rs11066028; rs4646779; rs16941669; rs440; rs7397491; rs11834780; rs16941667; rs4646775; rs11066029; rs35154896; rs11066024; rs2106696; rs11613231; rs2158028; rs4767035; rs13306166; rs34083959; rs7136890; rs13306164; rs1064933; rs34477327; rs34884061; rs28633753; rs11442381; rs11615695; rs11066023; rs35511855; rs35781311; rs13306163; rs7397456; rs35050853; rs35642129; rs12312867; rs12829533; rs11407827; rs34480430; rs12314397; rs35264878; rs12813835; rs12322000; rs34896918; rs35650885; rs7970477; rs11066025; rs13306167; rs11066027; rs12301347; rs11614684; rs35700215; rs35746295; rs34587287; rs13306165; rs35786282; rs11066022; rs7397469; rs11066030; rs10450717; rs35693865; rs11503169; rs35546929; rs33973376; rs34497874; rs12830829; rs35061167; rs11609093; rs36073646; rs34108639; rs12824249; rs11610258; rs35147079; rs11613713; rs11066026; rs7486832; rs12099590; rs3832868; rs34300515; rs35212101; rs7398472; rs35239056; rs35752199; rs5800933; rs11613351; rs5023470; rs34587619; rs4646781; rs4646780; rs11304348; rs12305979; rs4646782; rs10849969; rs10849971; rs11066032; rs14630; rs2339839; rs2339840; rs7133964; rs737280; rs739580; rs7974339; rs7978737; rs9971942

# Metabolic_Enzyme_6_General_References:
3582651; 3562250; 2838413; 4065146; 2987944; 4015823; 3610592; 3653404; 6582480; 8561277; 10631996

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5531

# Metabolic_Enzyme_7_Name:
Fatty aldehyde dehydrogenase

# Metabolic_Enzyme_7_Synonyms:
Aldehyde dehydrogenase, microsomal; Aldehyde dehydrogenase family 3 member A2; Aldehyde dehydrogenase 10

# Metabolic_Enzyme_7_Gene_Name:
ALDH3A2

# Metabolic_Enzyme_7_Protein_Sequence:
>Fatty aldehyde dehydrogenase
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE
VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ
PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH
IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT
CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI
AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA
LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS
HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV
KAEYY

# Metabolic_Enzyme_7_Number_of_Residues:
485

# Metabolic_Enzyme_7_Molecular_Weight:
54849

# Metabolic_Enzyme_7_Theoretical_pI:
7.99

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_7_Specific_Function:
Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length

# Metabolic_Enzyme_7_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_7_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
464-480

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_7_GenBank_ID_Protein:
1082036

# Metabolic_Enzyme_7_SwissProt_ID:
AL3A2_HUMAN (P51648)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
ALDH3A2

# Metabolic_Enzyme_7_Geneatlas_id:
ALDH3A2

# Metabolic_Enzyme_7_hgnc_id:
HGNC:403

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein; cytoplasmic side

# Metabolic_Enzyme_7_Gene_Sequence:
>1458 bp
ATGGAGCTCGAAGTCCGGCGGGTCCGACAGGCGTTCCTGTCCGGCCGGTCGCGACCTCTG
CGGTTTCGGCTGCAGCAGCTGGAGGCCCTGCGGAGGATGGTGCAGGAGCGCGAGAAGGAT
ATCCTGACGGCCATCGCCGCCGACCTGTGCAAGAGTGAATTCAATGTGTACAGTCAGGAA
GTCATTACTGTCCTTGGGGAAATTGATTTTATGCTTGAGAATCTTCCTGAATGGGTTACT
GCTAAACCAGTTAAGAAGAACGTGCTCACCATGCTGGATGAGGCCTATATTCAGCCACAG
CCTCTGGGAGTGGTGCTGATAATCGGAGCTTGGAATTACCCCTTCGTTCTCACCATTCAG
CCACTGATAGGAGCCATCGCTGCAGGAAATGCTGTGATTATAAAGCCTTCTGAACTGAGT
GAAAATACAGCCAAGATCTTGGCAAAGCTTCTCCCTCAGTATTTAGACCAGGATCTCTAT
ATTGTTATTAATGGTGGTGTTGAGGAAACCACGGAGCTCCTGAAGCAGCGATTTGACCAC
ATTTTCTATACGGGAAACACTGCGGTTGGCAAAATTGTCATGGAAGCTGCTGCCAAGCAT
CTGACCCCTGTGACTCTTGAACTGGGAGGGAAAAGTCCATGTTATATTGATAAAGATTGT
GACCTGGACATTGTTTGCAGACGCATAACCTGGGGAAAATACATGAATTGTGGCCAAACC
TGCATTGCACCCGACTATATTCTCTGTGAAGCATCCCTCCAAAATCAAATTGTATGGAAG
ATTAAGGAAACAGTGAAGGAATTTTATGGAGAAAATATAAAAGAGTCTCCTGATTATGAA
AGGATCATCAATCTTCGTCATTTTAAGAGGATACTAAGTTTGCTTGAAGGACAAAAGATA
GCTTTTGGTGGGGAGACTGATGAGGCCACACGCTACATAGCCCCAACAGTACTTACCGAT
GTTGATCCTAAAACCAAGGTGATGCAAGAAGAAATTTTTGGACCAATTCTTCCAATAGTG
CCTGTGAAAAATGTAGATGAGGCCATAAATTTCATAAATGAACGTGAAAAGCCTCTGGCT
CTTTATGTATTTTCGCATAACCATAAGCTCATCAAACGGATGATTGATGAGACATCCAGT
GGAGGTGTCACAGGCAATGACGTCATTATGCACTTCACGCTCAACTCTTTCCCATTTGGA
GGAGTGGGTTCCAGTGGGATGGGAGCTTATCACGGAAAACATAGTTTTGATACTTTTTCT
CATCAGCGTCCCTGTTTATTAAAAAGTTTAAAGAGAGAAGGTGCTAACAAACTCAGATAT
CCTCCCAACAGCCAGTCAAAGGTGGATTGGGGGAAATTTTTTCTCTTGAAACGGTTCAAC
AAAGAAAAACTCGGTCTCCTGTTGCTCACTTTCCTGGGTATTGTAGCCGCTGTGCTTGTC
AAGGCAGAATATTACTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
L47162

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_7_Locus:
17p11.2

# Metabolic_Enzyme_7_SNPs:
rs7216; rs7503517; rs7215; rs16420; rs11204408; rs3786038; rs962801; rs2072333; rs1034897; rs2072331; rs2108971; rs1004490; rs1004491; rs4244600; rs962800; rs8069576; rs4925036; rs2072332; rs16960280; rs4646797; rs8069478; rs2386145; rs1800869; rs11204407; rs4646798; rs4646794; rs4925038; rs4646800; rs4925037; rs4646795; rs4646804; rs4646802; rs8073767; rs12937946; rs9910300; rs4646801; rs9901895; rs1034896; rs3760489; rs4621031; rs3888642; rs1057405; rs11548343; rs12947169; rs34160909; rs35364675; rs7209322; rs35495378; rs12947168; rs12708; rs4646805; rs7215552; rs35965955; rs2386146; rs35716578; rs34082599; rs4646799; rs4646796; rs3034928; rs1800870; rs35581449; rs5819686; rs34567842; rs34350257; rs34642385; rs4646793; rs11652177; rs4646907; rs34471504; rs8073053; rs2386147; rs6146012; rs34945824; rs36031953; rs34327718; rs35797108; rs34664206; rs4646803; rs35265843; rs36025724; rs35053333; rs3841513; rs34368630; rs4646806; rs35604266; rs16960266; rs28375263; rs11868363; rs11871420; rs11871642; rs12937179; rs1804608; rs2386144; rs34399035; rs34416664; rs35526408; rs4646807; rs4925026; rs8065688; rs8074204; rs8074500

# Metabolic_Enzyme_7_General_References:
8528251; 9027499; 9070922; 9254849; 9829906

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5526

# Metabolic_Enzyme_8_Name:
4-trimethylaminobutyraldehyde dehydrogenase

# Metabolic_Enzyme_8_Synonyms:
TMABADH; Aldehyde dehydrogenase 9A1; Aldehyde dehydrogenase E3 isozyme; Gamma-aminobutyraldehyde dehydrogenase; R- aminobutyraldehyde dehydrogenase

# Metabolic_Enzyme_8_Gene_Name:
ALDH9A1

# Metabolic_Enzyme_8_Protein_Sequence:
>4trimethylaminobutyraldehyde dehydrogenase
MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA
AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY
AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK
PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI
MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI
LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY
VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA
AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL
KTVCVEMGDVESAF

# Metabolic_Enzyme_8_Number_of_Residues:
494

# Metabolic_Enzyme_8_Molecular_Weight:
53802

# Metabolic_Enzyme_8_Theoretical_pI:
5.61

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_8_Specific_Function:
Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction

# Metabolic_Enzyme_8_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_8_Reaction:
4-trimethylammoniobutanal + NAD+ = 4-trimethylammoniobutanoate + NADH + H+

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.2.1.47;EC 1.2.1.3;EC

# Metabolic_Enzyme_8_GenBank_ID_Protein:
1049219

# Metabolic_Enzyme_8_SwissProt_ID:
AL9A1_HUMAN (P49189)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
ALDH9A1

# Metabolic_Enzyme_8_Geneatlas_id:
ALDH9A1

# Metabolic_Enzyme_8_hgnc_id:
HGNC:412

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_8_Gene_Sequence:
>1482 bp
ATGAGCACTGGCACCTTCGTCGTGTCGCAGCCGCTCAATTACCGCGGCGGGGCCGCTGGA
GCCGGCGGACGCTCCGGTACCGAGAAAGCTTTCGAGCCAGCAACCGGCCGAGTGATAGCT
ACTTTCACATGTTCAGGAGAAAAGGAAGTAAATTTGGCTGTTCAAAATGCAAAGGCTGCT
TTTAAAATATGGAGTCAAAAATCTGGCATGGAGCGTTGCCGAATCCTTTTGGAGGCTGCC
AGGATAATAAGGGAACGGGAGGATGAAATTGCTACTATGGAGTGCATCAACAATGGCAAG
TCCATCTTTGAGGCCCGCTTGGACATTGACATTTCCTGGCAGTGCCTGGAGTATTATGCG
GGCTTGGCTGCATCCATGGCTGGTGAACACATCCAGCTCCCAGGTGGATCGTTTGGTTAT
ACCAGAAGAGAACCACTTGGGGTATGTGTGGGAATAGGAGCATGGAACTACCCCTTTCAG
ATTGCCTCTTGGAAGTCGGCTCCAGCATTAGCCTGTGGTAATGCCATGGTCTTTAAACCT
TCTCCCTTTACACCTGTTTCTGCATTGCTACTGGCTGAAATCTACAGTGAGGCTGGTGTA
CCTCCTGGGCTCTTCAATGTGGTGCAGGGAGGGGCTGCCACAGGCCAGTTTCTGTGTCAG
CATCCCGATGTGGCCAAAGTCTCCTTCACTGGAAGTGTGCCCACTGGCATGAAGATCATG
GAGATGTCAGCTAAAGGAATCAAACCTGTTACCTTGGAACTTGGAGGCAAATCTCCACTC
ATCATCTTCTCAGACTGTGATATGAACAATGCTGTAAAGGGGGCGCTGATGGCCAACTTC
CTCACACAAGGCCAGGTTTGCTGTAATGGCACAAGAGTATTTGTGCAGAAAGAAATTCTT
GATAAATTTACAGAGGAAGTGGTGAAACAGACCCAAAGGATTAAAATTGGAGATCCCCTT
CTGGAAGATACAAGGATGGGTCCACTCATCAACCGACCACACCTGGAGCGAGTCCTTGGG
TTTGTCAAAGTGGCAAAGGAGCAGGGTGCTAAAGTGTTATGTGGTGGAGATATATATGTA
CCTGAAGATCCCAAATTAAAGGATGGATATTACATGAGACCTTGTGTATTAACTAATTGC
AGAGACGACATGACCTGTGTGAAGGAAGAGATCTTTGGGCCTGTTATGTCCATTTTATCA
TTTGACACTGAAGCTGAGGTTCTAGAAAGAGCCAATGATACCACTTTTGGACTAGCAGCT
GGCGTCTTTACCAGGGACATCCAACGGGCTCATAGAGTGGTAGCTGAGCTTCAGGCTGGG
ACGTGCTTCATTAACAACTATAACGTCAGCCCAGTGGAGTTGCCCTTTGGTGGATATAAG
AAGTCAGGATTTGGCAGAGAGAACGGCCGTGTGACAATCGAATATTATTCACAGCTGAAG
ACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
U34252

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_8_Locus:
1q23.1

# Metabolic_Enzyme_8_SNPs:
rs1065756; rs11808728; rs1143659; rs11506; rs12670; rs12408101; rs1913844; rs2882006; rs10753688; rs4646891; rs4646889; rs7516126; rs12565874; rs3820362; rs10800129; rs10800128; rs7534437; rs12072634; rs4656457; rs1337442; rs2348728; rs4578194; rs12080699; rs7541817; rs10918239; rs2348727; rs3738192; rs6683969; rs12065621; rs2348734; rs16849230; rs6426930; rs12083232; rs7513998; rs12122497; rs7555787; rs4646886; rs10800127; rs10918252; rs2348729; rs4646883; rs7518869; rs10800133; rs2176151; rs4646882; rs1538115; rs10800131; rs4646897; rs6690818; rs2050619; rs10753689; rs7546084; rs12076579; rs17482717; rs4657463; rs10918235; rs11587760; rs4274037; rs12567331; rs4557947; rs1337443; rs10800130; rs10800132; rs4646895; rs16849238; rs17450889; rs12033254; rs12069198; rs6657651; rs10918245; rs3845537; rs10918237; rs11807857; rs11807866; rs884121; rs4657462; rs10918236; rs7543204; rs2184918; rs12070650; rs17417191; rs9970857; rs6662419; rs7367737; rs10918242; rs10918241; rs7546322; rs4646888; rs16849374; rs12409168; rs12037790; rs10918247; rs7537071; rs12084748; rs10918238; rs7368130; rs2348730; rs10918244; rs4233407; rs12123278; rs4646892; rs4657466; rs4576644; rs6683651; rs6667075; rs12021795; rs6683665; rs12081464; rs7546215; rs7519162; rs10918240; rs6667088; rs6669697; rs12081903; rs4646885; rs7542184; rs16849479; rs4646887; rs12072664; rs10753687; rs4646896; rs10157944; rs6668102; rs3753893; rs4657468; rs3753892; rs7553712; rs7511691; rs7554409; rs7544840; rs6426928; rs6667681; rs4646881; rs1415503; rs11555775; rs9164; rs4646902; rs6667510; rs11555774; rs4307543; rs11436915; rs34948330; rs12139219; rs34495301; rs10918248; rs1890080; rs35894201; rs4646884; rs28759374; rs12137604; rs28589393; rs34662022; rs12354157; rs10918246; rs35087657; rs34105906; rs35913333; rs34664103; rs12083492; rs2271658; rs34872122; rs7512816; rs4646893; rs7527514; rs12566251; rs1970286; rs3831954; rs2348731; rs10918249; rs35178491; rs36027739; rs35864611; rs17416948; rs4646894; rs11583089; rs12742656; rs12754903; rs12742657; rs41267568; rs4646890; rs12084651; rs4646900; rs34304173; rs13376536; rs12727801; rs41326750; rs28439296; rs12134617; rs12036561; rs35531113; rs3845536; rs36011778; rs12090132; rs7525102; rs10918250; rs3738191; rs12239517; rs4646898; rs34072474; rs34945812; rs10918251; rs1890079; rs35439339; rs36150573; rs1577847; rs12728137; rs34846458; rs4646901; rs36110991; rs12083091; rs34894576; rs6426927; rs11458950; rs1856143; rs35757606; rs41267564; rs41267566; rs35742388; rs10494446; rs10494447; rs10800123; rs10800125; rs10800126; rs10800135; rs10800136; rs10918228; rs10918229; rs10918231; rs10918254; rs10918255; rs10918256; rs11579160; rs11800476; rs11810856; rs12027066; rs12028588; rs12043815; rs12044709; rs12060366; rs12143472; rs12748251; rs1547725; rs16848876; rs16848958; rs16849041; rs16849616; rs1878074; rs1878075; rs2090281; rs2297762; rs2297763; rs2297764; rs2297765; rs3753894; rs3795540; rs4147602; rs4147604; rs4147605; rs4147610; rs4147611; rs4341347; rs7527279; rs7549511; rs7551594; rs8133; rs9333483; rs9333487; rs9919190

# Metabolic_Enzyme_8_General_References:
8786138; 10702312; 8645224; 8269919; 2925663

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5527

# Metabolic_Enzyme_9_Name:
Aldehyde dehydrogenase, dimeric NADP-preferring

# Metabolic_Enzyme_9_Synonyms:
ALDH class 3; ALDHIII

# Metabolic_Enzyme_9_Gene_Name:
ALDH3A1

# Metabolic_Enzyme_9_Protein_Sequence:
>Aldehyde dehydrogenase, dimeric NADPpreferring
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH

# Metabolic_Enzyme_9_Number_of_Residues:
453

# Metabolic_Enzyme_9_Molecular_Weight:
50380

# Metabolic_Enzyme_9_Theoretical_pI:
6.52

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_9_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes

# Metabolic_Enzyme_9_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_9_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_9_GenBank_ID_Protein:
178402

# Metabolic_Enzyme_9_SwissProt_ID:
AL3A1_HUMAN (P30838)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
ALDH3A1

# Metabolic_Enzyme_9_Geneatlas_id:
ALDH3A1

# Metabolic_Enzyme_9_hgnc_id:
HGNC:405

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_9_Gene_Sequence:
>1362 bp
ATGAGCAAGATCAGCGAGGCCGTGAAGCGCGCCCGCGCCGCCTTCAGCTCGGGCAGGACC
CGTCCGCTGCAGTTCCGATTCCAGCAGCTGGAGGCGCTGCAGCGCCTGATCCAGGAGCAG
GAGCAGGAGCTGGTGGGCGCGCTGGCCGCAGACCTGCACAAGAATGAATGGAACGCCTAC
TATGAGGAGGTGGTGTACGTCCTAGAGGAGATCGAGTACATGATCCAGAAGCTCCCTGAG
TGGGCCGCGGATGAGCCCGTGGAGAAGACGCCCCAGACTCAGCAGGACGAGCTCTACATC
CACTCGGAGCCACTGGGCGTGGTCCTCGTCATTGGCACCTGGAACTACCCCTTCAACCTC
ACCATCCAGCCCATGGTGGGCGCCATCGCTGCAGGGAACGCAGTGGTCCTCAAGCCCTCG
GAGCTGAGTGAGAACATGGCGAGCCTGCTGGCTACCATCATCCCCCAGTACCTGGACAAG
GATCTGTACCCAGTAATCAATGGGGGTGTCCCTGAGACCACGGAGCTGCTCAAGGAGAGG
TTCGACCATATCCTGTACACGGGCAGCACGGGGGTGGGGAAGATCATCATGACGGCTGCT
GCCAAGCACCTGACCCCTGTCACGCTGGAGCTGGGAGGGAAGAGTCCCTGCTACGTGGAC
AAGAACTGTGACCTGGACGTGGCCTGCCGACGCATCGCCTGGGGGAAATTCATGAACAGT
GGCCAGACCTGCGTGGCCCCAGACTACATCCTCTGTGACCCCTCGATCCAGAACCAAATT
GTGGAGAAGCTCAAGAAGTCACTGAAAGAGTTCTACGGGGAAGATGCTAAGAAATCCCGG
GACTATGGAAGAATCATTAGTGCCCGGCACTTCCAGAGGGTGATGGGCCTGATTGAGGGC
CAGAAGGTGGCTTATGGGGGCACCGGGGATGCCGCCACTCGCTACATAGCCCCCACCATC
CTCACGGACGTGGACCCCCAGTCCCCGGTGATGCAAGAGGAGATCTTCGGGCCTGTGCTG
CCCATCGTGTGCGTGCGCAGCCTGGAGGAGGCCATCCAGTTCATCAACCAGCGTGAGAAG
CCCCTGGCCCTCTACATGTTCTCCAGCAACGACAAGGTGATTAAGAAGATGATTGCAGAG
ACATCCAGTGGTGGGGTGGCGGCCAACGATGTCATCGTCCACATCACCTTGCACTCTCTG
CCCTTCGGGGGCGTGGGGAACAGCGGCATGGGATCCTACCATGGCAAGAAGAGCTTCGAG
ACTTTCTCTCACCGCCGCTCTTGCCTGGTGAGGCCTCTGATGAATGATGAAGGCCTGAAG
GTCAGATACCCCCCGAGCCCGGCCAAGATGACCCAGCACTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
M74542

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_9_Locus:
17p11.2

# Metabolic_Enzyme_9_SNPs:
rs887241; rs2228100; rs3744692; rs2072330; rs4646787; rs1042183; rs917520; rs4646789; rs4646788; rs3786036; rs887240; rs2072329; rs4646790; rs3744693; rs9895030; rs3826507; rs3744695; rs3744694; rs2072328; rs1006556; rs4319825; rs1042172; rs11554977; rs11554978; rs11554975; rs11554974; rs34474118; rs3786037; rs35473971; rs4646792; rs35116940; rs4646791; rs35853488; rs887239; rs28531080; rs7216299; rs35009373; rs3786035; rs11385990; rs35308039; rs35128135; rs35885485; rs28552545; rs34438543; rs1006553; rs11650088; rs11651480; rs11870332; rs12948881; rs12949049; rs12951039; rs16960382; rs16960386; rs17793620; rs1989379; rs2016823; rs2052052; rs2072327; rs2108967; rs3760485; rs3760486; rs3760487; rs4646783; rs4646784; rs4646785; rs4646786; rs4924793; rs4925046; rs7214841; rs7221211; rs7225305; rs8075157; rs9898715; rs9900430

# Metabolic_Enzyme_9_General_References:
1737758; 8493892; 2037078; 9250352

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5528

# Metabolic_Enzyme_10_Name:
Alpha-aminoadipic semialdehyde dehydrogenase

# Metabolic_Enzyme_10_Synonyms:
Alpha-AASA dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenease; P6c dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1

# Metabolic_Enzyme_10_Gene_Name:
ALDH7A1

# Metabolic_Enzyme_10_Protein_Sequence:
>Alphaaminoadipic semialdehyde dehydrogenase
MSTLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADY
EETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQ
EYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIA
MICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVN
LLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQ
RCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEA
KKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWN
NEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRES
GSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ

# Metabolic_Enzyme_10_Number_of_Residues:
511

# Metabolic_Enzyme_10_Molecular_Weight:
55367

# Metabolic_Enzyme_10_Theoretical_pI:
6.86

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_10_Specific_Function:
L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H

# Metabolic_Enzyme_10_Pathway:
map00300  Lysine biosynthesis;
 map00310  Lysine degradation

# Metabolic_Enzyme_10_Reaction:
L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 1.2.1.31

# Metabolic_Enzyme_10_GenBank_ID_Protein:
797410

# Metabolic_Enzyme_10_SwissProt_ID:
AL7A1_HUMAN (P49419)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
ALDH7A1

# Metabolic_Enzyme_10_Geneatlas_id:
ALDH7A1

# Metabolic_Enzyme_10_hgnc_id:
HGNC:877

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Not Available

# Metabolic_Enzyme_10_Gene_Sequence:
>1536 bp
ATGTCCACTCTCCTCATCAATCAGCCCCAGTATGCGTGGCTGAAAGAGCTGGGGCTCCGC
GAGGAAAACGAGGGCGTGTATAATGGAAGCTGGGGAGGCCGGGGAGAGGTTATTACGACC
TATTGCCCCGCTAACAACGAGCCAATAGCAAGAGTCCGACAGGCCAGTGTGGCAGACTAT
GAAGAAACTGTAAAGAAAGCAAGAGAAGCATGGAAAATCTGGGCAGATATTCCTGCTCCA
AAACGAGGAGAAATAGTAAGACAGATTGGCGATGCCTTGCGGGAGAAGATCCAAGTACTA
GGAAGCTTGGTGTCTTTGGAGATGGGGAAAATCTTAGTGGAAGGTGTGGGTGAAGTTCAG
GAGTATGTGGATATCTGTGACTATGCTGTTGGTTTATCAAGGATGATTGGAGGACCTATC
TTGCCTTCTGAAAGATCTGGCCATGCACTGATTGAGCAGTGGAATCCCGTAGGCCTGGTT
GGAATCATCACGGCATTCAATTTCCCTGTGGCAGTGTATGGTTGGAACAACGCCATCGCC
ATGATCTGTGGAAATGTCTGCCTCTGGAAAGGAGCTCCAACCACTTCCCTCATTAGTGTG
GCTGTCACAAAGATAATAGCCAAGGTTCTGGAGGACAACAAGCTGCCTGGTGCAATTTGT
TCCTTGACTTGTGGTGGAGCAGATATTGGCACAGCAATGGCCAAAGATGAACGAGTGAAC
CTGCTGTCCTTCACTGGGAGCACTCAGGTGGGAAAACAGGTGGGCCTGATGGTGCAGGAG
AGGTTTGGGAGAAGTCTGTTGGAACTTGGAGGAAACAATGCCATTATTGCCTTTGAAGAT
GCAGACCTCAGCTTAGTTGTTCCATCAGCTCTCTTCGCTGCTGTGGGAACAGCTGGCCAG
AGGTGTACCACTGCGAGGCGACTGTTTATACATGAAAGCATCCATGATGAGGTTGTAAAC
AGACTTAAAAAGGCCTATGCACAGATCCGAGTTGGGAACCCATGGGACCCTAATGTTCTC
TATGGGCCACTCCACACCAAGCAGGCAGTGAGCATGTTTCTTGGAGCAGTGGAAGAAGCA
AAGAAAGAAGGTGGCACAGTGGTCTATGGGGGCAAGGTTATGGATCGCCCTGGAAATTAT
GTAGAACCGACAATTGTGACAGGTCTTGGCCACGATGCGTCCATTGCACACACAGAGACT
TTCGCTCCGATTCTCTATGTCTTTAAATTCAAGAATGAAGAAGAGGTCTTTGCATGGAAT
AATGAAGTAAAACAGGGACTTTCAAGTAGCATCTTTACCAAAGATCTGGGCAGAATCTTT
CGCTGGCTTGGACCTAAAGGATCAGACTGTGGCATTGTAAATGTCAACATTCCAACAAGT
GGGGCTGAGATTGGAGGTGCCTTTGGAGGAGAAAAGCACACTGGTGGTGGCAGGGAGTCT
GGCAGTGATGCCTGGAAACAGTACATGAGAAGGTCTACTTGTACTATCAACTACAGTAAA
GACCTTCCTCTGGCCCAAGGAATCAAGTTTCAGTAA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
S74728

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_10_Locus:
5q31

# Metabolic_Enzyme_10_SNPs:
rs12514417; rs2306618; rs2775; rs1038381; rs6595719; rs4835912; rs1038378; rs1038380; rs2306617; rs4379190; rs4836276; rs11241901; rs4240406; rs12513847; rs7709115; rs4836272; rs7713264; rs6870785; rs11241902; rs7714044; rs1038379; rs10050642; rs7723008; rs4836277; rs3734175; rs6898430; rs17154671; rs4626334; rs13182402; rs17154679; rs4835914; rs12653605; rs2306619; rs7719675; rs10478743; rs7700981; rs2035472; rs11241903; rs6861395; rs7724875; rs2291295; rs10519915; rs7719712; rs6898559; rs4626335; rs17154676; rs11952752; rs13179664; rs4835913; rs11742214; rs3734174; rs11742381; rs7736031; rs7737529; rs10478744; rs4836275; rs17154666; rs34241005; rs10043987; rs7718426; rs2013986; rs10067785; rs7719091; rs17165056; rs13188450; rs900645; rs7708281; rs7703958; rs7723494; rs10050872; rs7702811; rs13171814; rs6897789; rs13177576; rs7704283; rs4526102; rs11741551; rs10038571; rs4836273; rs3736174; rs3736171; rs1483780; rs900641; rs744722; rs900640; rs7718710; rs1060856; rs744720; rs17165061; rs744721; rs1807; rs6865317; rs6884473; rs7447092; rs3189320; rs1049217; rs1049211; rs11542969; rs1049214; rs11269202; rs6898845; rs35027610; rs35284915; rs34275373; rs35570062; rs34674137; rs28429591; rs7730016; rs4612066; rs36058537; rs2408702; rs11406545; rs1142071; rs13356526; rs35492150; rs34697893; rs10539406; rs34825424; rs7703752; rs12187161; rs34949719; rs36125577; rs36077292; rs7719949; rs35736560; rs34201518; rs33926729; rs34250591; rs13185811; rs34323751; rs34907915; rs28865092; rs35559498; rs35109136; rs10630162; rs4836274; rs34972014; rs13173864; rs7709981; rs6870070; rs2408703; rs35118533; rs10532390; rs34517958; rs34069611; rs10629966; rs7706009; rs34496788; rs34935903; rs35115612; rs13174679; rs10609859; rs34995966; rs34074703; rs36120385; rs34424711; rs34537297; rs7737783; rs35457522; rs35367836; rs36017518; rs17597559; rs7730933; rs33954485; rs35196030; rs35930104; rs34575294; rs10666972; rs10676689; rs35010266; rs34035179; rs28629815; rs7704352; rs35797169; rs10044223; rs35622239; rs35960414; rs34959052; rs35342756; rs13154789; rs4836278; rs35617751; rs34731336; rs12656014; rs34305021; rs34684581; rs5871220; rs11951146; rs35290920; rs13166319; rs2408633; rs11290126; rs34862437; rs35992646; rs35110442; rs10609860; rs11742868; rs6896807; rs17531712; rs34770295; rs3080835; rs11387172; rs7737256; rs34601459; rs9765047; rs1060857; rs3736172; rs11458774; rs1138001; rs7447380; rs5871218; rs1138005; rs34410568; rs3736173; rs35569843; rs744723; rs5871219; rs34450389; rs34135005; rs3830274; rs11750167; rs1384880; rs17154635; rs2035471; rs2128931; rs2306620; rs2306621; rs2306622; rs2408700; rs28365789; rs3734173; rs4240405; rs4597966; rs4835911; rs4836271; rs6882015; rs730870; rs7715516; rs7726892

# Metabolic_Enzyme_10_General_References:
8088832; 9417906

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5529

# Metabolic_Enzyme_11_Name:
Aldehyde dehydrogenase 1A3

# Metabolic_Enzyme_11_Synonyms:
Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3

# Metabolic_Enzyme_11_Gene_Name:
ALDH1A3

# Metabolic_Enzyme_11_Protein_Sequence:
>Aldehyde dehydrogenase 1A3
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI
CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM
DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW
NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV
GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE
CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK
QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL
KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF
KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP

# Metabolic_Enzyme_11_Number_of_Residues:
512

# Metabolic_Enzyme_11_Molecular_Weight:
56109

# Metabolic_Enzyme_11_Theoretical_pI:
7.29

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_11_Specific_Function:
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system

# Metabolic_Enzyme_11_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_11_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_11_GenBank_ID_Protein:
544482

# Metabolic_Enzyme_11_SwissProt_ID:
AL1A3_HUMAN (P47895)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
ALDH1A3

# Metabolic_Enzyme_11_Geneatlas_id:
ALDH1A3

# Metabolic_Enzyme_11_hgnc_id:
HGNC:409

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_11_Gene_Sequence:
>1539 bp
ATGGCCACCGCTAACGGGGCCGTGGAAAACGGGCAGCCGGACGGGAAGCCGCCGGCCCTG
CCGCGCCCCATCCGCAACCTGGAGGTCAAGTTCACCAAGATATTTATCAACAATGAATGG
CACGAATCCAAGAGTGGGAAAAAGTTTGCTACATGTAACCCTTCAACTCGGGAGCAAATA
TGTGAAGTGGAAGAAGGAGATAAGCCCGACGTGGACAAGGCTGTGGAGGCTGCACAGGTT
GCCTTCCAGAGGGGCTCGCCATGGCGCCGGCTGGATGCCCTGAGTCGTGGGCGGCTGCTG
CACCAGCTGGCTGACCTGGTGGAGAGGGACCGCGCCACCTTGGCCGCCCTGGAGACGATG
GATACAGGGAAGCCATTTCTTCATGCTTTTTTCATCGACCTGGAGGGCTGTATTAGAACC
CTCAGATACTTTGCAGGGTGGGCAGACAAAATCCAGGGCAAGACCATCCCCACAGATGAC
AACGTCGTATGCTTCACCAGGCATGAGCCCATTGGTGTCTGTGGGGCCATCACTCCATGG
AACTTCCCCCTGCTGATGCTGGTGTGGAAGCTGGCACCCGCCCTCTGCTGTGGGAACACC
ATGGTCCTGAAGCCTGCGGAGCAGACACCTCTCACCGCCCTTTATCTCGGCTCTCTGATC
AAAGAGGCCGGGTTCCCTCCAGGAGTGGTGAACATTGTGCCAGGATTCGGGCCCACAGTG
GGAGCAGCAATTTCTTCTCACCCTCAGATCAACAAGATCGCCTTCACCGGCTCCACAGAG
GTTGGAAAACTGGTTAAAGAAGCTGCGTCCCGGAGCAATCTGAAGCGGGTGACGCTGGAG
CTGGGGGGGAAGAACCCCTGCATCGTGTGTGCGGACGCTGACTTGGACTTGGCAGTGGAG
TGTGCCCATCAGGGAGTGTTCTTCAACCAAGGCCAGTGTTGCACGGCAGCCTCCAGGGTG
TTCGTGGAGGAGCAGGTCTACTCTGAGTTTGTCAGGCGGAGCGTGGAGTATGCCAAGAAA
CGGCCCGTGGGAGACCCCTTCGATGTCAAAACAGAACAGGGGCCTCAGATTGATCAAAAG
CAGTTCGACAAAATCTTAGAGCTGATCGAGAGTGGGAAGAAGGAAGGGGCCAAGCTGGAA
TGCGGGGGCTCAGCCATGGAAGACAAGGGGCTCTTCATCAAACCCACTGTCTTCTCAGAA
GTCACAGACAACATGCGGATTGCCAAAGAGGAGATTTTCGGGCCAGTGCAACCAATACTG
AAGTTCAAAAGTATCGAAGAAGTGATAAAAAGAGCGAATAGCACCGACTATGGACTCACA
GCAGCCGTGTTCACAAAAAATCTCGACAAAGCCCTGAAGTTGGCTTCTGCCTTAGAGTCT
GGAACGGTCTGGATCAACTGCTACAACGCCCTCTATGCACAGGCTCCATTTGGTGGCTTT
AAAATGTCAGGAAATGGCAGAGAACTAGGTGAATACGCTTTGGCCGAATACACAGAAGTG
AAAACTGTCACCATCAAACTTGGCGACAAGAACCCCTGA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
U07919

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_11_Locus:
15q26.3

# Metabolic_Enzyme_11_SNPs:
rs3803430; rs2229183; rs1130738; rs14226; rs3803424; rs7045; rs3803426; rs7182089; rs4646690; rs7161860; rs4246328; rs4646688; rs4646668; rs4646670; rs3803428; rs4646671; rs6598396; rs4646675; rs9944290; rs7181897; rs4646684; rs4246323; rs4246327; rs4246329; rs4646674; rs8039374; rs4646678; rs4646653; rs4646655; rs7182884; rs3809521; rs11854028; rs3825926; rs3803433; rs6598397; rs4646662; rs4646685; rs4646651; rs4646672; rs3922685; rs4646654; rs3902902; rs4646683; rs7176046; rs3803432; rs4246324; rs4646661; rs8030776; rs12903828; rs4646687; rs4646680; rs3825925; rs7178221; rs3803427; rs7170197; rs4246325; rs8023972; rs4646681; rs7167278; rs4246326; rs1886; rs4646649; rs12908902; rs7171776; rs3803429; rs12914598; rs4646669; rs4646650; rs3803434; rs4646660; rs4646682; rs3809524; rs3809523; rs3809526; rs7179268; rs1130737; rs3803431; rs1130768; rs34302490; rs28760343; rs35300460; rs1802602; rs1802604; rs4288979; rs3803425; rs1802603; rs4646663; rs28691047; rs28731371; rs34655770; rs35165034; rs28509297; rs10400871; rs35129664; rs12905372; rs28405557; rs34486175; rs28546254; rs35055541; rs4646686; rs28441320; rs28410143; rs4646676; rs4646648; rs8029933; rs12910188; rs34182689; rs28504296; rs28449981; rs28507582; rs3825927; rs35310246; rs12910025; rs28384196; rs4343265; rs12910662; rs8028283; rs28475530; rs4392045; rs28369514; rs28377287; rs8035722; rs28480133; rs28707102; rs28583888; rs4646666; rs7173413; rs28472416; rs28673034; rs28668881; rs28711429; rs34837038; rs4646659; rs28452487; rs28712665; rs12910029; rs12902704; rs4646673; rs28689536; rs28431101; rs34431941; rs7178645; rs28454526; rs7170202; rs1889; rs4646647; rs4375646; rs11348272; rs4646656; rs28408085; rs28699556; rs28615197; rs28539744; rs28557216; rs28631565; rs34302839; rs3923499; rs4646664; rs35740226; rs28385499; rs3922686; rs28474807; rs28490217; rs12909825; rs10593974; rs28679806; rs28610999; rs7178553; rs35519561; rs35831758; rs35526807; rs4646658; rs28538652; rs28685242; rs10400842; rs4646667; rs35948146; rs4646677; rs7165217; rs10400872; rs28750207; rs3825924; rs7171453; rs34906846; rs4646665; rs9920154; rs36081993; rs11435500; rs28464660; rs4646679; rs12595234; rs4646689; rs3809522; rs35950557; rs3809527; rs7172149; rs7178931; rs8034153; rs7183889; rs3809525; rs4646646; rs11630601; rs11630691; rs11632820; rs11637204; rs11854709; rs12148466; rs12148493; rs12440023; rs12593839; rs12901792; rs12907776; rs12908105; rs12909230; rs12909791; rs28507591; rs3803435; rs4346184; rs4646694; rs7163108; rs7164136; rs7181644; rs8034686; rs8035036

# Metabolic_Enzyme_11_General_References:
7698756

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
6878

# Metabolic_Enzyme_12_Name:
Catalase

# Metabolic_Enzyme_12_Synonyms:
Not Available

# Metabolic_Enzyme_12_Gene_Name:
CAT

# Metabolic_Enzyme_12_Protein_Sequence:
>Catalase
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT
KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD
THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE
HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK
NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL

# Metabolic_Enzyme_12_Number_of_Residues:
527

# Metabolic_Enzyme_12_Molecular_Weight:
59757

# Metabolic_Enzyme_12_Theoretical_pI:
7.41

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  catalase activity
 ||
>>>
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_12_Specific_Function:
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide

# Metabolic_Enzyme_12_Pathway:
map00380  Tryptophan metabolism;
 map00680  Methane metabolism

# Metabolic_Enzyme_12_Reaction:
2 H2O2 = O2 + 2 H2O

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00199:Catalase

# Metabolic_Enzyme_12_Signals:
None

# Metabolic_Enzyme_12_Transmembrane_Regions:
None

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 1.11.1.6

# Metabolic_Enzyme_12_GenBank_ID_Protein:
1228085

# Metabolic_Enzyme_12_SwissProt_ID:
CATA_HUMAN (P04040)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
CAT

# Metabolic_Enzyme_12_Geneatlas_id:
CAT

# Metabolic_Enzyme_12_hgnc_id:
HGNC:1516

# Metabolic_Enzyme_12_PDB_ID:
1F4J

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_12_Gene_Sequence:
>66 bp
ATGGCTGACAGCCGGGATCCCGCCAGCGACCAGATGCAGCACTGGAAGGAGCAGCGGGCC
GCGCAG

# Metabolic_Enzyme_12_GenBank_ID_Gene:
X04085

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_12_Locus:
11p13

# Metabolic_Enzyme_12_SNPs:
rs17880442; rs11032709; rs769217; rs35677492; rs1049982; rs2234940; rs1050032; rs566979; rs769218; rs511895; rs524167; rs494024; rs1408035; rs560807; rs10488736; rs2284367; rs482322; rs7947841; rs480496; rs11032699; rs2300182; rs2284365; rs7103083; rs499406; rs3758730; rs4755372; rs508370; rs7933285; rs1000343; rs554576; rs2073059; rs11032701; rs17886008; rs4755373; rs484214; rs6484722; rs543701; rs17884666; rs2420389; rs551929; rs480575; rs10836244; rs2179625; rs7113917; rs2268063; rs533425; rs12272630; rs17881488; rs486256; rs17884576; rs2073058; rs11604331; rs17884491; rs7120960; rs1408034; rs524154; rs7109778; rs7101395; rs17881288; rs12269988; rs7126610; rs10836235; rs16925608; rs16925614; rs11824384; rs2284368; rs17883121; rs2420388; rs4756146; rs16925606; rs17884086; rs2284364; rs7930427; rs12803540; rs1408036; rs17268652; rs2284366; rs17881567; rs2300181; rs7928213; rs11032702; rs16925581; rs525938; rs11032700; rs17881921; rs17884095; rs17885743; rs17881476; rs17883793; rs11826620; rs12270780; rs35915891; rs2268064; rs17883592; rs17884725; rs17881482; rs17880673; rs2284369; rs17883544; rs11032703; rs12273124; rs17884248; rs35755143; rs7126640; rs2076556; rs4755374; rs1055981; rs17884335; rs17884518; rs17880274; rs17883699; rs4756148; rs17886200; rs475043; rs564250; rs769214; rs9282626; rs7943316; rs9282627; rs7104301; rs17883920; rs1001179; rs17881029; rs17886350; rs2266625; rs34455645; rs3180560; rs11546300; rs1050028; rs2266629; rs2266619; rs14527; rs2266628; rs35012776; rs34964953; rs34727149; rs3831770; rs17886810; rs35927227; rs7121850; rs17885881; rs17882812; rs17885837; rs17880607; rs17882039; rs17881916; rs17880549; rs34138762; rs28586982; rs34503767; rs36074933; rs515130; rs35099202; rs35849009; rs17881846; rs17887048; rs17881224; rs17884421; rs34840731; rs17881231; rs35340649; rs35292563; rs17884242; rs12286702; rs35034960; rs28733253; rs17887248; rs35791482; rs35703808; rs35648206; rs34808995; rs35386961; rs34420404; rs856714; rs17883483; rs17884804; rs17883367; rs17883534; rs17880160; rs17886672; rs34281397; rs34790990; rs2982523; rs35122257; rs2284370; rs12798927; rs35781217; rs11032707; rs17886592; rs4483566; rs34890123; rs4272763; rs12789374; rs17881734; rs35330036; rs17883434; rs35081167; rs17886155; rs17886248; rs34840787; rs34890990; rs17881192; rs17881586; rs34267165; rs12786539; rs35834969; rs3818354; rs17884443; rs36224415; rs36224416; rs36224102; rs10312; rs10836230; rs10836233; rs10836234; rs11032717; rs1107573; rs11606946; rs12284341; rs12807961; rs12808450; rs1323690; rs1535718; rs1535719; rs1535720; rs1535721; rs16925525; rs2073057; rs208678; rs208679; rs208681; rs208682; rs208683; rs2231828; rs2266624; rs2266630; rs2296144; rs409598; rs554518; rs7109862; rs7114869; rs7118388; rs7928156; rs7941147; rs7944397; rs7949972

# Metabolic_Enzyme_12_General_References:
3755525; 3755526; 11728823; 8282800; 12665801; 6548744; 10666617; 10656833; 11134921

# Metabolic_Enzyme_12_References:
193557; 6521729; 9272859

# Metabolic_Enzyme_13_ID:
6085

# Metabolic_Enzyme_13_Name:
Transketolase

# Metabolic_Enzyme_13_Synonyms:
TK

# Metabolic_Enzyme_13_Gene_Name:
TKT

# Metabolic_Enzyme_13_Protein_Sequence:
>Transketolase
MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKS
QDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDV
ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA
ILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIA
KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN
IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFI
ECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVS
IGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII
YNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPL
DRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAE
LLKMFGIDRDAIAQAVRGLITKA

# Metabolic_Enzyme_13_Number_of_Residues:
623

# Metabolic_Enzyme_13_Molecular_Weight:
67878

# Metabolic_Enzyme_13_Theoretical_pI:
7.73

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring aldehyde or ketonic groups
Function:  transketolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_13_Specific_Function:
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

# Metabolic_Enzyme_13_Pathway:
map00030  Pentose phosphate pathway;
 map00710  Carbon fixation;
 map01051  Biosynthesis of ansamycins

# Metabolic_Enzyme_13_Reaction:
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF02779:Transket_pyr;
PF02780:Transketolase_C;
PF00456:Transketolase_N

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
None

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 2.2.1.1

# Metabolic_Enzyme_13_GenBank_ID_Protein:
37267

# Metabolic_Enzyme_13_SwissProt_ID:
TKT_HUMAN (P29401)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
TKT

# Metabolic_Enzyme_13_Geneatlas_id:
TKT

# Metabolic_Enzyme_13_hgnc_id:
HGNC:11834

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Not Available

# Metabolic_Enzyme_13_Gene_Sequence:
>1872 bp
ATGGAGAGCTACCACAAGCCTGACCAGCAGAAGCTGCAGGCCTTGAAGGACACGGCCAAC
CGCCTACGTATCAGCTCCATCCAGGCCTCCTCTGCGGCGGGCTCTGGCCACCCCACGTCA
TGCTGCAGCGCCGCAGTGATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTCC
CAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCC
ATCCTCTACGCGGTCTGGGCTGAAGCTGGTTTCCTGGCCGAGGCGGAGCTGCTGAACCTG
AGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGTG
GCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAA
TACTTCGACAAGGCCAGCTACCGAGTCTATTGCTTGCTGGGAGATGGGGAGCTGTCAGAG
GGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGCC
ATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCGCTGCAGCACCAGATGGAC
ATCTACCAGAAGCGGTGCGAGGCCTTCGGTTGGCATGCCATCATCGTGGATGGACACAGC
GTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGCC
AAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAG
CCCCTCCCCAAAAACATGGCTGAGCAGATCATCCAGGAGATCTACAGCCAGATCCAGAGC
AAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAAC
ATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCC
TACGGGCAGGCACTGGCCAAGCTGGGCCATGCCAGTGACCGCATCATCGCCCTGGATGGG
GACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCATC
GAGTGCTACATTGCCGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAAC
AGGACGGTGCCCTTCTGCAGCACTTTTGCAGCCTTCTTCACGCGGGCCTTTGACCAGATT
CGCATGGCGGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTCC
ATCGGGGAAGACGGGGCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTC
CCCACATCAACTGTCTTTTACCCAAGTGATGGCGTTGCTACAGAGAAGGCAGTGGAACTA
GCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCATC
TATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGAT
GACCAGGTGACCGTTATCGGGGCTGGGGTGACCCTGCACGAGGCCTTGGCCGCTGCCGAA
CTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCTG
GACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAG
GACCATTATTATGAAGGTGGCATTGGTGAGGCTGTGTCCAGTGCAGTAGTGGGCGAGCCT
GGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCAGCTGAG
CTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATC
ACCAAGGCCTAG

# Metabolic_Enzyme_13_GenBank_ID_Gene:
X67688

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_13_Locus:
3p14.3

# Metabolic_Enzyme_13_SNPs:
rs17052920; rs3163; rs6785374; rs1051485; rs1051483; rs2035450; rs4267636; rs4687715; rs6768738; rs900494; rs3773745; rs10433616; rs968702; rs7628245; rs7633598; rs12493802; rs7650103; rs7610113; rs3773747; rs7633966; rs11720625; rs2306569; rs4687717; rs9850440; rs6787685; rs3773743; rs2279323; rs735940; rs9827244; rs7356056; rs11717767; rs2242301; rs3821691; rs17234092; rs11717712; rs3736154; rs2279321; rs9879195; rs3736153; rs3773742; rs12487632; rs728910; rs9820968; rs7631667; rs3816767; rs7649481; rs7647720; rs2358621; rs9858133; rs12630643; rs9864057; rs9284890; rs3773739; rs3773746; rs7609596; rs2242302; rs3736156; rs7627444; rs7640493; rs7617474; rs6445573; rs2242303; rs11130362; rs12635973; rs2279322; rs9846315; rs3773740; rs12629909; rs7646760; rs2242300; rs4687718; rs12633001; rs2884495; rs6793773; rs9826552; rs4687716; rs9820979; rs2279320; rs3773744; rs9858502; rs7625237; rs7630632; rs9830594; rs1545857; rs6782597; rs2077693; rs12494824; rs9818458; rs12487568; rs10433618; rs6793684; rs11719464; rs10433617; rs13101181; rs13075304; rs7612011; rs9311494; rs12633000; rs12485313; rs3736155; rs2242304; rs6445572; rs13074156; rs3773741; rs11130365; rs12632671; rs3736151; rs17306163; rs17030933; rs13093936; rs34466346; rs3162; rs11556003; rs11556004; rs4687714; rs1802929; rs11556002; rs11556006; rs41275537; rs34601275; rs2229693; rs1140826; rs1140825; rs11305678; rs35203736; rs12638638; rs34084206; rs11130364; rs9835964; rs10620591; rs34995533; rs35075155; rs10703271; rs35048890; rs10212420; rs34310421; rs41275543; rs2358620; rs7356096; rs6786157; rs34089717; rs10666288; rs13091081; rs10668063; rs35041022; rs12054426; rs28758191; rs34095201; rs9850314; rs1351703; rs35712428; rs41389846; rs35495179; rs35643056; rs34243738; rs5848979; rs5848978; rs12629312; rs7430638; rs35154296; rs9875011; rs9859430; rs41275539; rs35936646; rs9830895; rs34146825; rs13059189; rs7626730; rs35171987; rs10049441; rs35205801; rs34618710; rs35246063; rs41275541; rs3821692; rs33924283; rs41275535; rs41332244; rs3075727; rs34276819; rs35110726; rs9868820; rs35794580; rs34107310; rs34838231; rs7431404; rs11297416; rs3075723; rs9833188; rs10622320; rs9858049; rs1056082; rs3832231; rs1056076; rs35706165; rs1056083; rs9681418; rs35261010; rs11540529; rs11540530; rs17030930; rs17030934; rs11130358; rs11130367; rs11919567; rs12490667; rs12633545; rs12634987; rs13317770; rs17052954; rs17052957; rs1979491; rs34774173; rs4687573; rs6773409; rs6781629; rs7631103; rs7637556; rs7637934; rs7641951; rs7647990; rs7648309; rs931253; rs9852398

# Metabolic_Enzyme_13_General_References:
8419340; 12665801; 1567394

# Metabolic_Enzyme_13_References:
6250580; 6995116

# Metabolic_Enzyme_14_ID:
8070

# Metabolic_Enzyme_14_Name:
Glyoxylate reductase/hydroxypyruvate reductase

# Metabolic_Enzyme_14_Synonyms:
Not Available

# Metabolic_Enzyme_14_Gene_Name:
GRHPR

# Metabolic_Enzyme_14_Protein_Sequence:
>Glyoxylate reductase/hydroxypyruvate reductase
MRPVRLMKVFVTRRIPAEGRVALARAADCEVEQWDSDEPIPAKELERGVAGAHGLLCLLS
DHVDKRILDAAGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLL
TTCRRLPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRF
LYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVF
INISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIGSATHR
TRNTMSLLAANNLLAGLRGEPMPSELKL

# Metabolic_Enzyme_14_Number_of_Residues:
328

# Metabolic_Enzyme_14_Molecular_Weight:
35669

# Metabolic_Enzyme_14_Theoretical_pI:
7.44

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  L-serine metabolism
Process:  L-serine biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_14_Specific_Function:
Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities

# Metabolic_Enzyme_14_Pathway:
map00620  Pyruvate metabolism;
 map00630  Glyoxylate and dicarboxylate metabolism

# Metabolic_Enzyme_14_Reaction:
glycolate + NADP+ = glyoxylate + NADPH + H+

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00389:2-Hacid_dh;
PF02826:2-Hacid_dh_C

# Metabolic_Enzyme_14_Signals:
None

# Metabolic_Enzyme_14_Transmembrane_Regions:
None

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 1.1.1.79

# Metabolic_Enzyme_14_GenBank_ID_Protein:
6002730

# Metabolic_Enzyme_14_SwissProt_ID:
GRHPR_HUMAN (Q9UBQ7)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
GRHPR

# Metabolic_Enzyme_14_Geneatlas_id:
GRHPR

# Metabolic_Enzyme_14_hgnc_id:
HGNC:4570

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Not Available

# Metabolic_Enzyme_14_Gene_Sequence:
>987 bp
ATGAGACCGGTGCGACTCATGAAGGTGTTCGTCACCCGCAGGATACCCGCCGAGGGTAGG
GTCGCGCTCGCCCGGGCGGCAGACTGTGAGGTGGAGCAGTGGGACTCGGATGAGCCCATC
CCTGCCAAGGAGCTAGAGCGAGGTGTGGCGGGGGCCCACGGCCTGCTCTGCCTCCTCTCC
GACCACGTGGACAAGAGGATCCTGGATGCTGCAGGGGCCAATCTCAAAGTCATCAGCACC
ATGTCTGTGGGCATCGACCACTTGGCTTTGGATGAAATCAAGAAGCGTGGGATCCGAGTT
GGCTACACCCCAGATGTCCTGACAGATACCACCGCCGAACTCGCAGTCTCCCTGCTACTT
ACCACCTGCCGCCGGTTGCCGGAGGCCATCGAGGAAGTGAAGAATGGTGGCTGGACCTCG
TGGAAGCCCCTCTGGCTGTGTGGCTATGGACTCACGCAGAGCACTGTCGGCATCATCGGG
CTGGGGCGCATAGGCCAGGCCATTGCTCGGCGTCTGAAACCATTCGGTGTCCAGAGATTT
CTGTACACAGGGCGCCAGCCCAGGCCTGAGGAAGCAGCAGAATTCCAGGCAGAGTTTGTG
TCTACCCCTGAGCTGGCTGCCCAATCTGATTTCATCGTCGTGGCCTGCTCCTTAACACCT
GCAACCGAGGGACTCTGCAACAAGGACTTCTTCCAGAAGATGAAGGAAACAGCTGTGTTC
ATCAACATCAGCAGGGGCGACGTCGTAAACCAGGACGACCTGTACCAGGCCTTGGCCAGT
GGTAAGATTGCAGCTGCTGGACTGGATGTGACGAGCCCAGAACCACTGCCTACAAACCAC
CCTCTCCTGACCCTGAAGAACTGTGTGATTCTGCCCCACATTGGCAGTGCCACCCACAGA
ACCCGCAACACCATGTCCTTGTTGGCAGCTAACAACTTGCTGGCTGGCCTGAGAGGGGAG
CCGATGCCTAGTGAACTCAAGCTGTAG

# Metabolic_Enzyme_14_GenBank_ID_Gene:
AF134895

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_14_Locus:
9q12

# Metabolic_Enzyme_14_SNPs:
rs12002324; rs309458; rs309461; rs2768659; rs2736664; rs2768662; rs7867764; rs309455; rs309459; rs1887454; rs309453; rs2768658; rs12552734; rs309452; rs309460; rs309457; rs2235096; rs10973333; rs309456; rs309462; rs17885933; rs17411423; rs12683277; rs10973336; rs2768657; rs10973334; rs309454; rs4472607; rs7856656; rs4878690; rs7872991; rs10973329; rs7853540; rs7857159; rs10973327; rs10973328; rs7872720; rs6476631; rs7853526; rs11546642; rs35975284; rs11546644; rs1057507; rs3198078; rs2736669; rs2736662; rs2768660; rs2736670; rs35891798; rs2736673; rs34288288; rs41278295; rs41298174; rs2736665; rs2736660; rs2736667; rs10973335; rs2736671; rs2736661; rs41303225; rs16934118; rs2736663; rs1807410; rs35417895; rs2736666; rs2736674; rs10643023; rs2736668; rs34302950; rs11345501; rs2736672; rs309451; rs13299681; rs10973331; rs10679296; rs34280344; rs10973332; rs35292277; rs34688490; rs34632389; rs10643132; rs5897688; rs927929; rs34510989; rs10814535; rs10973324; rs10973338; rs10973339; rs10973340; rs11793053; rs12348205; rs13300415; rs17411255; rs17502738; rs1802995; rs2840246; rs309450; rs35680410; rs35720597; rs7022431; rs7031029; rs7038960; rs7039333

# Metabolic_Enzyme_14_General_References:
10524214; 10484776; 10679197

# Metabolic_Enzyme_14_References:
11237876; 7864371; 8538930

# Metabolic_Enzyme_15_ID:
8079

# Metabolic_Enzyme_15_Name:
Hydroxyacid oxidase 2

# Metabolic_Enzyme_15_Synonyms:
Long chain

# Metabolic_Enzyme_15_Gene_Name:
HAO2

# Metabolic_Enzyme_15_Protein_Sequence:
>Hydroxyacid oxidase 2
MEDKMWSECEGPEMSLVCLTDFQAHAREQLSKSTRDFIEGGADDSITRDDNIAAFKRIRL
RPRYLRDVSEVDTRTTIQGEEISAPICIAPTGFHCLVWPDGEMSTARAAQAAGICYITST
FASCSLEDIVIAAPEGLRWFQLYVHPDLQLNKQLIQRVESLGFKALVITLDTPVCGNRRH
DIRNQLRRNLTLTDLQSPKKGNAIPYFQMTPISTSLCWNDLSWFQSITRLPIILKGILTK
EDAELAVKHNVQGIIVSNHGGRQLDEVLASIDALTEVVAAVKGKIEVYLDGGVRTGNDVL
KALALGAKCIFLGRPILWGLACKGEHGVKEVLNILTNEFHTSMALTGCRSVAEINRNLVQ
FSRL

# Metabolic_Enzyme_15_Number_of_Residues:
364

# Metabolic_Enzyme_15_Molecular_Weight:
40392

# Metabolic_Enzyme_15_Theoretical_pI:
6.70

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_15_Specific_Function:
Not Available

# Metabolic_Enzyme_15_Pathway:
Not Available

# Metabolic_Enzyme_15_Reaction:
Not Available

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF01070:FMN_dh

# Metabolic_Enzyme_15_Signals:
None

# Metabolic_Enzyme_15_Transmembrane_Regions:
None

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 1.1.3.15

# Metabolic_Enzyme_15_GenBank_ID_Protein:
56205790

# Metabolic_Enzyme_15_SwissProt_ID:
Q5QP00_HUMAN (Q5QP00)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
HAO2

# Metabolic_Enzyme_15_Geneatlas_id:
HAO2

# Metabolic_Enzyme_15_hgnc_id:
HGNC:4810

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Not Available

# Metabolic_Enzyme_15_Gene_Sequence:
>1095 bp
ATGGAAGACAAGATGTGGAGTGAATGTGAAGGTCCAGAAATGTCCTTGGTGTGTTTGACA
GACTTTCAGGCCCATGCGCGAGAGCAGCTGTCTAAGTCAACTCGGGATTTTATTGAAGGT
GGAGCAGATGACAGCATCACGCGGGATGACAACATTGCAGCATTTAAAAGAATTCGCCTC
CGTCCGCGGTACCTGAGAGATGTGTCTGAGGTGGACACCAGAACCACAATCCAAGGGGAG
GAGATCAGTGCCCCTATTTGTATCGCACCCACAGGGTTCCACTGCCTTGTCTGGCCTGAT
GGGGAAATGAGCACAGCAAGAGCTGCCCAAGCGGCTGGTATCTGCTACATCACCAGCACA
TTTGCCAGCTGTAGCCTTGAAGACATTGTCATTGCAGCTCCCGAAGGCCTCCGATGGTTC
CAACTCTATGTGCATCCAGACCTGCAGCTGAACAAACAGTTGATCCAGAGGGTAGAATCC
CTAGGTTTCAAAGCTTTGGTAATAACTTTGGATACACCTGTATGTGGCAACAGGCGACAT
GACATTCGAAACCAGTTGAGGAGGAACTTAACACTAACAGATCTTCAATCACCTAAAAAG
GGAAATGCAATACCTTATTTCCAGATGACTCCTATCAGCACTTCTCTCTGCTGGAATGAT
CTCTCCTGGTTTCAGAGCATAACTCGATTGCCCATCATCCTGAAAGGGATTTTGACAAAA
GAGGATGCAGAGTTAGCTGTGAAGCACAATGTCCAGGGTATCATTGTTTCCAACCATGGT
GGGAGGCAGCTTGATGAGGTTCTTGCTTCAATTGATGCTTTGACAGAAGTGGTGGCTGCT
GTAAAGGGGAAAATTGAAGTCTACCTGGATGGCGGGGTCCGAACTGGCAATGATGTGCTG
AAGGCTCTGGCCCTTGGAGCTAAGTGCATTTTTCTTGGGAGACCAATCCTATGGGGCCTT
GCCTGCAAGGGTGAACATGGTGTTAAGGAAGTTTTGAACATTTTAACAAATGAGTTCCAC
ACTTCCATGGCCCTTACAGGCTGCCGGTCGGTCGCTGAGATCAATCGAAACTTGGTCCAG
TTTTCCAGGCTGTAA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
AL359553

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_15_Locus:
1p13.3-p13.1

# Metabolic_Enzyme_15_SNPs:
rs34638261; rs2275607; rs35295280; rs2224995; rs3765953; rs3765955; rs3765951; rs3765956; rs10923804; rs7514283; rs6667104; rs3765952; rs10494225; rs6694847; rs6667203; rs10923802; rs6691943; rs7513419; rs12071883; rs6704362; rs7529983; rs3753260; rs4659003; rs3765954; rs3765957; rs10802090; rs17023507; rs17013697; rs1341007; rs2298028; rs6670497; rs6667679; rs2275608; rs1417604; rs7552690; rs2298027; rs12032036; rs6663287; rs3765949; rs3207643; rs6428816; rs10923805; rs7528838; rs2182243; rs17023517; rs3765950; rs11586988; rs9728422; rs10802092; rs6675731; rs3753263; rs3753264; rs3753262; rs6656360; rs3753261; rs12402209; rs6661625; rs41313995; rs41306185; rs4659002; rs11398278; rs12753975; rs12118920; rs12743964; rs34875589; rs12724529; rs7547008; rs36096589; rs35468112; rs35672626; rs35324941; rs35351478; rs12404377; rs35476629; rs3753259; rs4659004; rs11582039; rs10585699; rs11366732; rs41313280; rs6678290; rs34306563; rs28570107; rs41443445; rs3753265; rs3834006; rs3818927; rs3820031; rs10923808; rs12047811; rs12404344; rs12740687; rs1325751; rs1536228; rs17023479; rs1935248; rs2005390; rs2885607; rs35298838; rs3753266; rs3820032; rs6658331; rs6683756; rs879333; rs879334; rs942903; rs947127

# Metabolic_Enzyme_15_General_References:
Not Available

# Metabolic_Enzyme_15_References:
11305652; 16228304; 16657053; 16658319

# Metabolic_Enzyme_16_ID:
8537

# Metabolic_Enzyme_16_Name:
Methylmalonate semialdehyde dehydrogenase precursor

# Metabolic_Enzyme_16_Synonyms:
Not Available

# Metabolic_Enzyme_16_Gene_Name:
MMSADHA

# Metabolic_Enzyme_16_Protein_Sequence:
>Methylmalonate semialdehyde dehydrogenase precursor
RAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPATNEV
IGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQ
GKTLADAEGDVFRG

# Metabolic_Enzyme_16_Number_of_Residues:
134

# Metabolic_Enzyme_16_Molecular_Weight:
14780

# Metabolic_Enzyme_16_Theoretical_pI:
10.43

# Metabolic_Enzyme_16_GO_Classification:
>>>
 Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Energy production and conversion

# Metabolic_Enzyme_16_Specific_Function:
Not Available

# Metabolic_Enzyme_16_Pathway:
Not Available

# Metabolic_Enzyme_16_Reaction:
Not Available

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_16_Signals:
Not Available

# Metabolic_Enzyme_16_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 1.2.1.27

# Metabolic_Enzyme_16_GenBank_ID_Protein:
2708830

# Metabolic_Enzyme_16_SwissProt_ID:
O43573_HUMAN (O43573)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
MMSADHA

# Metabolic_Enzyme_16_Geneatlas_id:
MMSADHA

# Metabolic_Enzyme_16_hgnc_id:
HGNC:7179

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Not Available

# Metabolic_Enzyme_16_Gene_Sequence:
>401 bp
CGGGCAGTGCGAGCCCGGATCCTGCAGGTTTCTTCCAAGGTGAAATCCAGTCCCACCTGG
TATTCAGCATCTTCCTTCTCTTCTTCAGTGCCAACTGTAAAGCTCTTCATTGGTGGGAAA
TTCGTTGAATCCAAAAGTGACAAATGGATCGATATCCACAACCCAGCCACCAATGAGGTC
ATTGGTCGGGTCCCTCAGGCCACCAAGGCAGAAATGGATGCAGCCATTGCTTCCTGCAAA
CGTGCTTTTCCTGCATGGGCAGACACTTCAGTATTAAGCCGCCAGCAGGTCTTGCTCCGC
TATCAACAACTTATTAAAGAAAACTTGAAAGAAATTGCCAAGTTAATCACATTGGAACAA
GGGAAGACCCTAGCTGATGCTGAAGGAGATGTATTTCGAGG

# Metabolic_Enzyme_16_GenBank_ID_Gene:
AF038011

# Metabolic_Enzyme_16_Chromosome_Location:
Not Available

# Metabolic_Enzyme_16_Locus:
Not Available

# Metabolic_Enzyme_16_SNPs:
Not Available

# Metabolic_Enzyme_16_General_References:
Not Available

# Metabolic_Enzyme_16_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8202

# Macromolecular_Interacting_Partner_1_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_1_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_1_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_1_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_1_Locus:
10q22

# Macromolecular_Interacting_Partner_1_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_1_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_1_References:
10193963; 8634806; 8791575

End of HMDB00115

Beginning of HMDB00117
# Accession_No:
HMDB00117

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-09-27 22:07:18

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Ganglioside GM1

# Description:
A glycosphingolipid (ceramide and oligosaccharide) or oligoglycosylceramide with one or more sialic acids (i.e. n-acetylneuraminic acid) linked on the sugar chain. It is a component the cell plasma membrane which modulates cell signal transduction events. Gangliosides have been found to be highly important in immunology. Ganglioside GM1 carries a net-negative charge at pH 7.0 and is acidic. Gangliosides can amount to 6% of the weight of lipids from brain, but they are found at low levels in all animal tissues.

# Synonyms:
1-O-[O-(N-acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide; 1-O-[O-(N-acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-Ceramide; D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-Nacylsphingosine; D-Galactosyl-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide; GM1; GM1a; Gal-beta1->3GalNAc-beta1->4(Neu5Ac-alpha2>3)Gal-beta1->4Glc-beta1->1'Cer; Ganglioside GM1; II3NeuAcGgOse4Cer; N-Acetylganglioside GM1; N-acetyl-Ganglioside GM1; NeuAc-GM1a; 1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-Ceramide; 1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-Ceramide; delta-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-delta-galactosyl-delta-glucosyl-Nacylsphingosine; delta-Galactosyl-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-delta-galactosyl-delta-glucosylceramide

# Chemical_IUPAC_Name:
(2S,4S,5R,6R)-5-acetamido-6-[3-[(2R,3R,4R,5R,6R)-5-[(2S,3R,4R,5R,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-oxan-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(E)-3-hydroxy-2-(octadecanoylamino)octadec-4-enoxy]oxan-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-1,2-dihydroxy-propyl]-2,4-dihydroxy-oxane-2-carboxylic acid

# Chemical_Formula:
C73H131N3O31

# Chemical_Structure:
tbl_chemical:::HMDB00117_ZOOM.png:::119283197178953036

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00117_THUMB.png:::119283196948011138

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Glycolipids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
1,2-diol; secondary carboxylic acid amide; primary alcohol; alkene; heterocyclic compound; acetal; hemiacetal; carboxylic acid; secondary alcohol; dialkyl ether

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
1545.87671

# Molecular_Weight_Avg:
1546.82288

# Smiles_String_isomeric:
CCCCCCCCCCCCCCCCCC(=O)NC(CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O)[C@H]3NC(C)=O)[C@H](OCC(O)[C@H](O)[C@@H]5O[C@@](O)(C[C@H](O)[C@H]5NC(C)=O)C(O)=O)[C@H]2O)[C@H](O)[C@H]1O)C(O)C=CCCCCCCCCCCCCC

# Smiles_String_canonical:
CCCCCCCCCCCCCCCCCC(=O)NC(COC1OC(CO)C(OC2OC(CO)C(OC3OC(CO)C(O)C(OC4OC(CO)C(O)C(O)C4O)C3NC(C)=O)C(OCC(O)C(O)C5OC(O)(CC(O)C5NC(C)=O)C(O)=O)C2O)C(O)C1O)C(O)C=CCCCCCCCCCCCCC

# KEGG_Compound_ID:
C04911

# BioCyc_ID:
Not Available

# PubChem_CID:
6434235

# PubChem_SID:
179135;7461

# OMIM_ID:
176801

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
GM1

# METLIN_ID:
Not Available

# Ref_ID:
2026685; 1868675; 12900764; 7538811; 7785034; 12770782; 1590911; 3426245; 8464986; 9337086; 12374210; 9111177

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
104443-62-1

# InChI:
InChI=1/C73H131N3O31/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-52(86)76-44(45(83)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-99-69-61(93)59(91)63(50(38-79)102-69)104-71-62(94)67(98-41-47(85)55(87)66-53(74-42(3)81)46(84)35-73(97,107-66)72(95)96)64(51(39-80)103-71)105-68-54(75-43(4)82)65(57(89)49(37-78)100-68)106-70-60(92)58(90)56(88)48(36-77)101-70/h31,33,44-51,53-71,77-80,83-85,87-94,97H,5-30,32,34-41H2,1-4H3,(H,74,81)(H,75,82)(H,76,86)(H,95,96)/b33-31+/t44?,45?,46-,47?,48+,49+,50+,51+,53+,54+,55-,56-,57-,58-,59+,60+,61+,62+,63+,64-,65+,66+,67+,68-,69+,70-,71-,73-/m0/s1

# Synthesis_Reference:
Russian Journal of Bioorganic Chemistry (Translation of Bioorganicheskaya Khimiya)  (2003),  29(2),  168-174.

# Melting_Point:
Not Available

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
0.176 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
2.19 [Predicted by ALOGPS]; 1.7515 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00117.mol:::117503934446853385

# SDF_File_[Text]:
tbl_chemical:::HMDB00117.sdf:::119283195426150727

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00117.pdb:::119283196703929240

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Ganglioside GM1.gif:::1160769341327235

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00117_peaks.txt:::1174426579765476485

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Ganglioside GM1_C.gif:::11607693413332094

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00117_peaks.txt:::1174426596939721464

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane

# Tissue_Location:
Brain; Fibroblasts; Myelin; Nerve Cells

# deuterated:
No

# Biofluid_Location:
Blood; Breast Milk; CSF; Feces; Urine

# Concentration_[Normal]:
Urine	<0.001	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	1868675
Blood	3.4	uM	Adult:>18_yrs_old	Both	Normal	1868675
Cerebrospinal_Fluid(CSF)	0.011 +/- 0.004	uM	Adult:>18_yrs_old	Both	Normal	1294245
Breast_Milk	0.0083432	uM	Adult:>18_yrs_old	Female	Normal	10887501


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Fibromyalgia Syndrome; Mononeuropathy; Tumour Necrosis

# Pathway_Names:
Glycerophospholipid metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00564

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5286

# Metabolic_Enzyme_1_Name:
1-O-acylceramide synthase precursor

# Metabolic_Enzyme_1_Synonyms:
ACS; Lysosomal phospholipase A2; Lysophospholipase 3; LPLA2; LCAT-like lysophospholipase; LLPL

# Metabolic_Enzyme_1_Gene_Name:
LYPLA3

# Metabolic_Enzyme_1_Protein_Sequence:
>1Oacylceramide synthase precursor
MGLHLRPYRVGLLPDGLLFLLLLLMLLADPALPAGRHPPVVLVPGDLGNQLEAKLDKPTV
VHYLCSKKTESYFTIWLNLELLLPVIIDCWIDNIRLVYNKTSRATQFPDGVDVRVPGFGK
TFSLEFLDPSKSSVGSYFHTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALREM
IEEMYQLYGGPVVLVAHSMGNMYTLYFLQRQPQAWKDKYIRAFVSLGAPWGGVAKTLRVL
ASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNYTWSPEKVFVQTPTINYTLRDYRKFFQ
DIGFEDGWLMRQDTEGLVEATMPPGVQLHCLYGTGVPTPDSFYYESFPDRDPKICFGDGD
GTVNLKSALQCQAWQSRQEHQVLLQELPGSEHIEMLANATTLAYLKRVLLGP

# Metabolic_Enzyme_1_Number_of_Residues:
412

# Metabolic_Enzyme_1_Molecular_Weight:
46658

# Metabolic_Enzyme_1_Theoretical_pI:
6.72

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
Function:  O-acyltransferase activity
Function:  phosphatidylcholine-sterol O-acyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N- acetylsphingosine and the concomitant release of a lyso- phospholipid. May have weak lysophospholipase activity

# Metabolic_Enzyme_1_Pathway:
Not Available

# Metabolic_Enzyme_1_Reaction:
Not Available

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF02450:LACT

# Metabolic_Enzyme_1_Signals:
1-33

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.1.1.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
4589720

# Metabolic_Enzyme_1_SwissProt_ID:
LYPA3_HUMAN (Q8NCC3)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
LYPLA3

# Metabolic_Enzyme_1_Geneatlas_id:
LYPLA3

# Metabolic_Enzyme_1_hgnc_id:
HGNC:17163

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Lysosome. Secreted protein

# Metabolic_Enzyme_1_Gene_Sequence:
>1239 bp
ATGGGCCTCCACCTCCGCCCCTACCGTGTGGGGCTGCTCCCGGATGGCCTCCTGTTCCTC
TTGCTGCTGCTAATGCTGCTCGCGGACCCAGCGCTCCCGGCCGGACGTCACCCCCCAGTG
GTGCTGGTCCCTGGTGATTTGGGTAACCAACTGGAAGCCAAGCTGGACAAGCCGACAGTG
GTGCACTACCTCTGCTCCAAGAAGACCGAAAGCTACTTCACAATCTGGCTGAACCTGGAA
CTGCTGCTGCCTGTCATCATTGACTGCTGGATTGACAATATCAGGCTGGTTTACAACAAA
ACATCCAGGGCCACCCAGTTTCCTGATGGTGTGGATGTACGTGTCCCTGGCTTTGGGAAG
ACCTTCTCACTGGAGTTCCTGGACCCCAGCAAAAGCAGCGTGGGTTCCTATTTCCACACC
ATGGTGGAGAGCCTTGTGGGCTGGGGCTACACACGGGGTGAGGATGTCCGAGGGGCTCCC
TATGACTGGCGCCGAGCCCCAAATGAAAACGGGCCCTACTTCCTGGCCCTCCGCGAGATG
ATCGAGGAGATGTACCAGCTGTATGGGGGCCCCGTGGTGCTGGTTGCCCACAGTATGGGC
AACATGTACACGCTCTACTTTCTGCAGCGGCAGCCGCAGGCCTGGAAGGACAAGTATATC
CGGGCCTTCGTGTCACTGGGTGCGCCCTGGGGGGGCGTGGCCAAGACCCTGCGCGTCCTG
GCTTCAGGAGACAACAACCGGATCCCAGTCATCGGGCCCCTGAAGATCCGGGAGCAGCAG
CGGTCAGCTGTCTCCACCAGCTGGCTGCTGCCCTACAACTACACATGGTCACCTGAGAAG
GTGTTCGTGCAGACACCCACAATCAACTACACACTGCGGGACTACCGCAAGTTCTTCCAG
GACATCGGCTTTGAAGATGGCTGGCTCATGCGGCAGGACACAGAAGGGCTGGTGGAAGCC
ACGATGCCACCTGGCGTGCAGCTGCACTGCCTCTATGGCACTGGCGTCCCCACACCAGAC
TCCTTCTACTATGAGAGCTTCCCTGACCGTGACCCTAAAATCTGCTTTGGTGACGGCGAT
GGTACTGTGAACTTGAAGAGTGCCCTGCAGTGCCAGGCCTGGCAGAGCCGCCAGGAGCAC
CAAGTGTTGCTGCAGGAGCTGCCAGGCAGCGAGCACATCGAGATGCTGGCCAACGCCACC
ACCCTGGCCTATCTGAAACGTGTGCTCCTTGGGCCCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AB017494

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_1_Locus:
16q22.1

# Metabolic_Enzyme_1_SNPs:
rs3743739; rs7672; rs9935022; rs1975802; rs2290700; rs16957784; rs12446418; rs1971546; rs3826164; rs10500543; rs12444188; rs8062085; rs12600062; rs2290699; rs17688065; rs11075670; rs8063214; rs10852439; rs17688076; rs7189794; rs28565410; rs34573759; rs34767979; rs11550043; rs9922331; rs35744179; rs3180464; rs34645528; rs11368218; rs34967472; rs12918044; rs3068687; rs36037115; rs5817633; rs12918043; rs28536091; rs35588224; rs35048006; rs3214854; rs12444774; rs12918145; rs36121098; rs3785110; rs8053594; rs9923137; rs10695552; rs168770; rs12324926; rs12918064; rs34546790; rs7184506; rs7189381; rs12325587; rs7189155; rs12324938; rs35155877; rs12102971; rs12447119; rs12596500; rs12924125; rs2863981; rs7184821; rs7187202; rs8056893; rs9930792; rs9933029

# Metabolic_Enzyme_1_General_References:
10092508; 12975309; 11790796

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5295

# Metabolic_Enzyme_2_Name:
Acyl-protein thioesterase 2

# Metabolic_Enzyme_2_Synonyms:
Lysophospholipase II; LPL- I

# Metabolic_Enzyme_2_Gene_Name:
LYPLA2

# Metabolic_Enzyme_2_Protein_Sequence:
>Acylprotein thioesterase 2
MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAP
RIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGG
FSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPMVP
VRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV

# Metabolic_Enzyme_2_Number_of_Residues:
231

# Metabolic_Enzyme_2_Molecular_Weight:
24737

# Metabolic_Enzyme_2_Theoretical_pI:
7.25

# Metabolic_Enzyme_2_GO_Classification:
Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity

# Metabolic_Enzyme_2_Pathway:
Not Available

# Metabolic_Enzyme_2_Reaction:
Not Available

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF02230:Abhydrolase_2

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.1.1.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
3859560

# Metabolic_Enzyme_2_SwissProt_ID:
LYPA2_HUMAN (O95372)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
LYPLA2

# Metabolic_Enzyme_2_Geneatlas_id:
LYPLA2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:6738

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm (Probable)

# Metabolic_Enzyme_2_Gene_Sequence:
>696 bp
ATGTGTGGTAACACCATGTCTGTGCCCCTGCTCACCGATGCTGCCACCGTGTCTGGAGCT
GAGCGGGAAACGGCCGCGGTTATTTTTTTACATGGACTTGGAGACACAGGGCACAGCTGG
GCTGACGCCCTCTCCACCATCCGGCTCCCTCACGTCAAGTACATCTGTCCCCATGCGCCT
AGGATCCCTGTGACCCTCAACATGAAGATGGTGATGCCCTCCTGGTTTGACCTGATGGGG
CTGAGTCCAGATGCCCCAGAGGACGAGGCTGGCATCAAGAAGGCAGCAGAGAACATCAAG
GCCTTGATTGAGCATGAAATGAAGAACGGGATCCCTGCCAATCGAATCGTCCTGGGAGGC
TTTTCACAGGGCGGGGCCCTGTCCCTCTACACGGCCCTCACCTGCCCCCACCCTCTGGCT
GGCATCGTGGCGTTGAGCTGCTGGCTGCCTCTGCACCGGGCCTTCCCCCAGGCAGCTAAT
GGCAGTGCCAAGGACCTGGCCATACTCCAGTGCCATGGGGAGCTGGACCCCATGGTGCCC
GTACGGTTTGGGGCCCTGACGGCTGAGAAGCTCCGGTCTGTTGTCACACCTGCCAGGGTC
CAGTTCAAGACATACCCGGGTGTCATGCACAGCTCCTGTCCTCAGGAGATGGCAGCTGTG
AAGGAATTTCTTGAGAAGCTGCTGCCTCCTGTCTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF098668

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_2_Locus:
1p36.12-p35.1

# Metabolic_Enzyme_2_SNPs:
rs2502985; rs2232982; rs2232979; rs11584220; rs2232978; rs2232985; rs2232986; rs2232984; rs3835423; rs2232976; rs2232977; rs2232981; rs2232980; rs2232983; rs2232975; rs35791072; rs1042436; rs1046924; rs1049988; rs11714; rs12031592; rs12131539; rs15778; rs1803612; rs1803613; rs2076343; rs2473381; rs2473382; rs28940882; rs28940883; rs28940885; rs3177810; rs3177811; rs3177814; rs3179862; rs3180382; rs3180383; rs3180545; rs3180546; rs3180547; rs3180549; rs3203593; rs3209973; rs6692104; rs760941

# Metabolic_Enzyme_2_General_References:
Not Available

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5289

# Metabolic_Enzyme_3_Name:
Cytosolic phospholipase A2

# Metabolic_Enzyme_3_Synonyms:
cPLA2; Phospholipase A2 group IVA[Includes: Phospholipase A2; Phosphatidylcholine 2- acylhydrolase; Lysophospholipase

# Metabolic_Enzyme_3_Gene_Name:
PLA2G4A

# Metabolic_Enzyme_3_Protein_Sequence:
>Cytosolic phospholipase A2
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRT
RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEV
PFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEG
LHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSH
PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIG
ETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYG
TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEE
LENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFN
TREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDV
KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN
KLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYKAPGVPRETE
EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRR
QNPSRCSVSLSNVEARRFFNKEFLSKPKA

# Metabolic_Enzyme_3_Number_of_Residues:
749

# Metabolic_Enzyme_3_Molecular_Weight:
85212

# Metabolic_Enzyme_3_Theoretical_pI:
5.03

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  lipase activity
Function:  phospholipase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  phospholipid metabolism
Process:  phospholipid catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response

# Metabolic_Enzyme_3_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_3_Reaction:
2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00168:C2;
PF01735:PLA2_B

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.1.1.4;EC 3.1.1.5

# Metabolic_Enzyme_3_GenBank_ID_Protein:
190007

# Metabolic_Enzyme_3_SwissProt_ID:
PA24A_HUMAN (P47712)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
PLA2G4A

# Metabolic_Enzyme_3_Geneatlas_id:
PLA2G4A

# Metabolic_Enzyme_3_hgnc_id:
HGNC:9035

# Metabolic_Enzyme_3_PDB_ID:
1CJY

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion

# Metabolic_Enzyme_3_Gene_Sequence:
>2250 bp
ATGTCATTTATAGATCCTTACCAGCACATTATAGTGGAGCACCAGTATTCCCACAAGTTT
ACGGTAGTGGTGTTACGTGCCACCAAAGTGACAAAGGGGGCCTTTGGTGACATGCTTGAT
ACTCCAGATCCCTATGTGGAACTTTTTATCTCTACAACCCCTGACAGCAGGAAGAGAACA
AGACATTTCAATAATGACATAAACCCTGTGTGGAATGAGACCTTTGAATTTATTTTGGAT
CCTAATCAGGAAAATGTTTTGGAGATTACGTTAATGGATGCCAATTATGTCATGGATGAA
ACTCTAGGGACAGCAACATTTACTGTATCTTCTATGAAGGTGGGAGAAAAGAAAGAAGTT
CCTTTTATTTTCAACCAAGTCACTGAAATGGTTCTAGAAATGTCTCTTGAAGTTTGCTCA
TGCCCAGACCTACGATTTAGTATGGCTCTGTGTGATCAGGAGAAGACTTTCAGACAACAG
AGAAAAGAACACATAAGGGAGAGCATGAAGAAACTCTTGGGTCCAAAGAATAGTGAAGGA
TTGCATTCTGCACGTGATGTGCCTGTGGTAGCCATATTGGGTTCAGGTGGGGGTTTCCGA
GCCATGGTGGGATTCTCTGGTGTGATGAAGGCATTATACGAATCAGGAATTCTGGATTGT
GCTACCTACGTTGCTGGTCTTTCTGGCTCCACCTGGTATATGTCAACCTTGTATTCTCAC
CCTGATTTTCCAGAGAAAGGGCCAGAGGAGATTAATGAAGAACTAATGAAAAATGTTAGC
CACAATCCCCTTTTACTTCTCACACCACAGAAAGTTAAAAGATATGTTGAGTCTTTATGG
AAGAAGAAAAGCTCTGGACAACCTGTCACCTTTACTGATATCTTTGGGATGTTAATAGGA
GAAACACTAATTCATAATAGAATGAATACTACTCTGAGCAGTTTGAAGGAAAAAGTTAAT
ACTGCACAATGCCCTTTACCTCTTTTCACCTGTCTTCATGTCAAACCTGACGTTTCAGAG
CTGATGTTTGCAGATTGGGTTGAATTTAGTCCATACGAAATTGGCATGGCTAAATATGGT
ACTTTTATGGCTCCCGACTTATTTGGAAGCAAATTTTTTATGGGAACAGTCGTTAAGAAG
TATGAAGAAAACCCCTTGCATTTCTTAATGGGTGTCTGGGGCAGTGCCTTTTCCATATTG
TTCAACAGAGTTTTGGGCGTTTCTGGTTCACAAAGCAGAGGCTCCACAATGGAGGAAGAA
TTAGAAAATATTACCACAAAGCATATTGTGAGTAATGATAGCTCGGACAGTGATGATGAA
TCACACGAACCCAAAGGCACTGAAAATGAAGATGCTGGAAGTGACTATCAAAGTGATAAT
CAAGCAAGTTGGATTCATCGTATGATAATGGCCTTGGTGAGTGATTCAGCTTTATTCAAT
ACCAGAGAAGGACGTGCTGGGAAGGTACACAACTTCATGCTGGGCTTGAATCTCAATACA
TCTTATCCACTGTCTCCTTTGAGTGACTTTGCCACACAGGACTCCTTTGATGATGATGAA
CTGGATGCAGCTGTAGCAGATCCTGATGAATTTGAGCGAATATATGAGCCTCTGGATGTC
AAAAGTAAAAAGATTCATGTAGTGGACAGTGGGCTCACATTTAACCTGCCGTATCCCTTG
ATACTGAGACCTCAGAGAGGGGTTGATCTCATAATCTCCTTTGACTTTTCTGCAAGGCCA
AGTGACTCTAGTCCTCCGTTCAAGGAACTTCTACTTGCAGAAAAGTGGGCTAAAATGAAC
AAGCTCCCCTTTCCAAAGATTGATCCTTATGTGTTTGATCGGGAAGGGCTGAAGGAGTGC
TATGTCTTTAAACCCAAGAATCCTGATATGGAGAAAGATTGCCCAACCATCATCCACTTT
GTTCTGGCCAACATCAACTTCAGAAAGTACAAGGCTCCAGGTGTTCCAAGGGAAACTGAG
GAAGAGAAAGAAATCGCTGACTTTGATATTTTTGATGACCCAGAATCACCATTTTCAACC
TTCAATTTTCAATATCCAAATCAAGCATTCAAAAGACTACATGATCTTATGCACTTCAAT
ACTCTGAACAACATTGATGTGATAAAAGAAGCCATGGTTGAAAGCATTGAATATAGAAGA
CAGAATCCATCTCGTTGCTCTGTTTCCCTTAGTAATGTTGAGGCAAGAAGATTTTTCAAC
AAGGAGTTTCTAAGTAAACCCAAAGCATAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M72393

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_3_Locus:
1q25

# Metabolic_Enzyme_3_SNPs:
rs2307198; rs12720691; rs10752976; rs4651331; rs2076075; rs7535459; rs12720707; rs11591148; rs12720485; rs3820185; rs10798059; rs12022299; rs12720496; rs1473676; rs12070719; rs6682761; rs6669230; rs6425051; rs10911930; rs11578084; rs6425050; rs11455181; rs10489406; rs4651330; rs12720495; rs2205897; rs9645303; rs16825998; rs12720708; rs7518131; rs12720488; rs12065442; rs12720490; rs12097836; rs10911927; rs7522183; rs12720486; rs2179189; rs2223307; rs2891262; rs1980444; rs2223309; rs2383555; rs726706; rs1018378; rs6672324; rs1474590; rs4336803; rs10798065; rs1569480; rs7555326; rs10737277; rs1160719; rs4650708; rs10752988; rs7545121; rs12062681; rs10911946; rs12068233; rs6678708; rs6690185; rs10911943; rs10798070; rs1569479; rs6682481; rs7542180; rs7519192; rs969357; rs932476; rs10752989; rs10911948; rs10911971; rs10798067; rs12072973; rs6697116; rs2307199; rs10737272; rs1033410; rs6678709; rs6698103; rs4651343; rs10752985; rs7554339; rs5027750; rs2383556; rs10798062; rs6683363; rs10911945; rs7542659; rs2207209; rs6695515; rs10911949; rs1003348; rs1977064; rs969358; rs2223308; rs10752983; rs2064115; rs6697145; rs763419; rs6683515; rs2891263; rs7540602; rs10157410; rs10911947; rs2307200; rs10798069; rs10911944; rs2383553; rs2891264; rs2049963; rs10911953; rs2383554; rs11587539; rs10911956; rs6661772; rs1980445; rs10489410; rs10911937; rs1555205; rs12129917; rs10798076; rs10489409; rs17591814; rs6425064; rs4650706; rs10911973; rs2024656; rs6682706; rs10911955; rs2076675; rs4272579; rs12720576; rs10798064; rs12404877; rs10911968; rs10911972; rs12720500; rs6425065; rs2273169; rs10911935; rs16826051; rs12567822; rs4650711; rs12720573; rs6425059; rs12720528; rs12720566; rs6666834; rs10489408; rs12564966; rs4651337; rs6686860; rs10911969; rs12720639; rs10798063; rs4651339; rs7547993; rs2383551; rs10911934; rs3736741; rs12720613; rs12720520; rs2307193; rs12406315; rs12720687; rs12563152; rs12066585; rs12091045; rs6688584; rs7526089; rs10798075; rs12720571; rs12720699; rs10911966; rs7555140; rs4651336; rs6704304; rs12720662; rs6664561; rs6685652; rs12749354; rs10798060; rs10911933; rs6693896; rs2307195; rs4433346; rs12726519; rs10489407; rs4402086; rs12720686; rs10798068; rs12720704; rs12720702; rs10911967; rs10737270; rs6425058; rs2891258; rs12720642; rs12353944; rs10737278; rs12720597; rs12131989; rs10911952; rs12042344; rs6686848; rs12720541; rs7526761; rs12720554; rs12720526; rs12353945; rs12409191; rs10911942; rs6425053; rs2307196; rs10737276; rs12746200; rs12401750; rs12139172; rs12720667; rs2064471; rs10752981; rs6699187; rs11576330; rs2223310; rs12720536; rs6665700; rs10752979; rs7521601; rs12567046; rs6678716; rs6696406; rs16826049; rs12144159; rs12720497; rs6662822; rs6425054; rs10737275; rs10911938; rs6683416; rs6425066; rs2307197; rs1555202; rs6690542; rs12720502; rs12720519; rs10688954; rs12720535; rs7416329; rs2142761; rs10752982; rs12407699; rs1555204; rs12128551; rs6683619; rs6662687; rs10752978; rs12131535; rs10737274; rs6678825; rs10752977; rs12073758; rs7522213; rs1160718; rs6425067; rs12568962; rs10911963; rs10157338; rs11802826; rs4651334; rs16826045; rs6656909; rs12073712; rs6685207; rs7547156; rs12720586; rs7541946; rs12720696; rs6691054; rs6672835; rs6695425; rs12720584; rs12720603; rs16670; rs6675898; rs12720572; rs35782442; rs4650712; rs12567071; rs2891261; rs12720625; rs16826065; rs12720565; rs6680308; rs16826055; rs6699070; rs12720537; rs12720508; rs12720605; rs10798073; rs12720700; rs12136279; rs7532616; rs6685195; rs12720658; rs16826181; rs12405420; rs12720650; rs12720654; rs12720622; rs10911951; rs6688358; rs12720556; rs12720680; rs12720560; rs12720514; rs2223909; rs12720552; rs12720527; rs12720637; rs12720549; rs6703952; rs10737273; rs10157406; rs975762; rs12720672; rs6683622; rs12720570; rs12720664; rs6425062; rs10798066; rs4276871; rs11805429; rs12720644; rs10911960; rs12720516; rs12720505; rs12720548; rs12720675; rs11806629; rs6675166; rs12720630; rs10911950; rs12720539; rs10732978; rs12720550; rs12720530; rs12720559; rs12691467; rs11577826; rs12720660; rs6700651; rs6675578; rs12720531; rs6685468; rs2207212; rs6690278; rs9803785; rs4650705; rs12720673; rs17601344; rs12720615; rs12567135; rs7547623; rs10737271; rs5007825; rs4651333; rs10798072; rs12720610; rs12720534; rs17591849; rs10798077; rs16826212; rs2223306; rs6683421; rs12720692; rs12720564; rs12720595; rs17526478; rs6668908; rs12720504; rs16826197; rs12720563; rs6425052; rs12090109; rs16826185; rs12720655; rs7534926; rs6688401; rs4650715; rs12720555; rs12720580; rs10911959; rs10752980; rs12720677; rs12720517; rs10158652; rs12567058; rs1555201; rs9804084; rs10798061; rs12720547; rs2383552; rs12720705; rs10911964; rs6688292; rs16826066; rs1033409; rs12720551; rs725892; rs5007826; rs12720628; rs12720638; rs12720582; rs12720633; rs2205898; rs11802050; rs10911931; rs12720511; rs4650709; rs10911958; rs12720684; rs10798074; rs1980446; rs12720557; rs12720617; rs12125857; rs12720676; rs7512281; rs12720561; rs16826060; rs11799495; rs12720594; rs2891259; rs7542836; rs6680303; rs7555537; rs12720690; rs10911965; rs12720544; rs16826042; rs2223305; rs12720581; rs7514702; rs12720634; rs5007824; rs6425055; rs6687896; rs4651332; rs12720689; rs12720694; rs12720669; rs12720656; rs2207213; rs979924; rs12720709; rs12720715; rs6684111; rs12720714; rs12720711; rs12720484; rs2066730; rs12720588; rs34758865; rs12720706; rs34500623; rs34278354; rs12720493; rs36079774; rs35180943; rs34635375; rs35145197; rs34795932; rs35339490; rs12093847; rs12744150; rs3795405; rs11543184; rs12095150; rs12720491; rs34716672; rs34429516; rs7521834; rs6662798; rs12720492; rs2307194; rs35977655; rs7525336; rs12734741; rs36062883; rs35641837; rs12084339; rs28595275; rs35960872; rs10911929; rs34827324; rs11810276; rs12070830; rs12720494; rs10651334; rs12720487; rs10911928; rs34397242; rs11577918; rs12734740; rs35762270; rs28679753; rs34496849; rs34438674; rs10566895; rs5779305; rs12033196; rs34724808; rs34832532; rs34045840; rs34986389; rs7513536; rs34537878; rs35209416; rs12720614; rs12720665; rs10712560; rs12720562; rs35723333; rs10609057; rs11371525; rs4650710; rs11406614; rs10695580; rs34215604; rs11371082; rs12720620; rs12720545; rs12742851; rs6702522; rs12720670; rs6671076; rs12720538; rs12720631; rs12720515; rs10911941; rs34711478; rs4651338; rs12720513; rs7522714; rs34670614; rs10911936; rs12720585; rs34385931; rs5779307; rs10752987; rs2207210; rs12720646; rs12720577; rs34340996; rs12753440; rs5779313; rs35091910; rs28633464; rs12751616; rs6679956; rs4007494; rs11399679; rs34101258; rs12128554; rs34680053; rs34586699; rs28412072; rs12720546; rs7527362; rs35773380; rs12720621; rs12022898; rs11390247; rs10700665; rs10592003; rs12720671; rs28691172; rs16826187; rs12745030; rs12720608; rs10911962; rs12720589; rs12720583; rs12720632; rs35131542; rs6682327; rs35260952; rs12720697; rs7544607; rs34405767; rs28676882; rs41264626; rs34416417; rs35443164; rs12566020; rs35801522; rs12032535; rs35069250; rs6691582; rs12095733; rs10752984; rs35183959; rs34391401; rs2205899; rs2205900; rs12129429; rs35047746; rs35174355; rs12131723; rs10911961; rs34709541; rs33956999; rs34677530; rs35412398; rs12088010; rs12720503; rs12720553; rs35618673; rs12141266; rs6696994; rs12720579; rs12720606; rs34191261; rs35003727; rs12720590; rs2207211; rs34356253; rs12071785; rs6675261; rs7546816; rs10627684; rs12720698; rs33958012; rs7524685; rs12122892; rs34414453; rs17592348; rs6683074; rs34543034; rs35037006; rs36037957; rs12063845; rs34089378; rs35264080; rs28606018; rs7413826; rs10538195; rs12720567; rs12074730; rs34098374; rs2383557; rs2891260; rs10911940; rs36020072; rs5779309; rs7545760; rs12720701; rs12720661; rs4540601; rs10708783; rs12720529; rs12720506; rs12057343; rs12720627; rs12720693; rs12720509; rs10631853; rs12720663; rs35389587; rs10708367; rs34107747; rs35813341; rs12720681; rs6662570; rs5779311; rs12742431; rs12738756; rs12758086; rs5779312; rs35947118; rs10702515; rs12720578; rs6703998; rs12720521; rs35425521; rs35800521; rs12720643; rs12720518; rs12720674; rs41264620; rs12720592; rs28493593; rs35050511; rs41516146; rs33948033; rs11375182; rs28863289; rs2017443; rs12720635; rs35712617; rs12720558; rs12720682; rs10674434; rs10609058; rs12720679; rs34796725; rs11388924; rs12720499; rs12720525; rs12720666; rs28896572; rs10599543; rs34632328; rs34437304; rs6425063; rs12720540; rs34350773; rs1467392; rs4650714; rs7536112; rs34147625; rs12720626; rs12720522; rs10596911; rs12720629; rs6685936; rs34920672; rs12730988; rs12121329; rs7526859; rs11428922; rs16826040; rs34398848; rs12720657; rs12720533; rs5014276; rs12720636; rs5779310; rs12720510; rs12744618; rs6425060; rs10634937; rs12720695; rs12720618; rs12720685; rs34820266; rs12125608; rs35455351; rs12720678; rs12720587; rs10911939; rs34441009; rs12744872; rs34503201; rs12720523; rs7520075; rs12720542; rs11426942; rs12088931; rs12143244; rs10633079; rs12720703; rs11460224; rs35869038; rs6678801; rs12128380; rs6675277; rs2143998; rs34952820; rs33991046; rs10578509; rs12720507; rs12720641; rs6425061; rs6674263; rs41264622; rs11268618; rs12720575; rs12730485; rs34117619; rs12720524; rs3060324; rs12720640; rs11307887; rs12720543; rs35673805; rs12720569; rs12129578; rs12720601; rs12720683; rs12143166; rs12747953; rs12720668; rs5007827; rs12409076; rs6670830; rs1555203; rs6695438; rs11441392; rs10647657; rs34948178; rs35146633; rs11314983; rs34814979; rs12097804; rs10689140; rs12720574; rs12720688; rs12077935; rs11387651; rs34068761; rs5007828; rs34866477; rs12730349; rs12720653; rs10707298; rs28878026; rs28634506; rs10709187; rs35257640; rs35387925; rs34796478; rs34017667; rs10752986; rs4262498; rs11410376; rs34113977; rs28749294; rs34023737; rs5779306; rs12720498; rs35843046; rs10585011; rs12720512; rs35114616; rs34490217; rs12744998; rs7416510; rs12720616; rs35566402; rs35454348; rs11320837; rs10657628; rs35523045; rs11805955; rs35126168; rs41519945; rs41264624; rs36064066; rs10647022; rs4650713; rs12720501; rs12071782; rs35214657; rs10603183; rs34029312; rs6678891; rs12720593; rs7551458; rs10681360; rs12123893; rs7523149; rs41453146; rs12720483; rs10158368; rs7556320; rs11802141; rs12066562; rs12720710; rs12066511; rs5779304; rs12092415; rs12720712; rs12720713; rs12066519; rs12066344; rs10752990; rs10798078; rs10911976; rs10911978; rs11590854; rs12037836; rs12746284; rs1474797; rs2143999; rs2144000; rs4651345; rs6661727; rs6696144; rs7414079; rs7544719; rs761517

# Metabolic_Enzyme_3_General_References:
1904318; 1869522; 8381049; 11416127; 9430701; 9665851

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5300

# Metabolic_Enzyme_4_Name:
Cardiotrophin-like cytokine factor 1 precursor

# Metabolic_Enzyme_4_Synonyms:
B cell-stimulating factor 3; BSF-3; Novel neurotrophin-1; NNT-1

# Metabolic_Enzyme_4_Gene_Name:
CLCF1

# Metabolic_Enzyme_4_Protein_Sequence:
>Cardiotrophinlike cytokine factor 1 precursor
MDLRAGDSWGMLACLCTVLWHLPAVPALNRTGDPGPGPSIQKTYDLTRYLEHQLRSLAGT
YLNYLGPPFNEPDFNPPRLGAETLPRATVDLEVWRSLNDKLRLTQNYEAYSHLLCYLRGL
NRQAATAELRRSLAHFCTSLQGLLGSIAGVMAALGYPLPQPLPGTEPTWTPGPAHSDFLQ
KMDDFWLLKELQTWLWRSAKDFNRLKKKMQPPAAAVTLHLGAHGF

# Metabolic_Enzyme_4_Number_of_Residues:
225

# Metabolic_Enzyme_4_Molecular_Weight:
25176

# Metabolic_Enzyme_4_Theoretical_pI:
8.61

# Metabolic_Enzyme_4_GO_Classification:
Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor

# Metabolic_Enzyme_4_Pathway:
Not Available

# Metabolic_Enzyme_4_Reaction:
Not Available

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF06875:PRF

# Metabolic_Enzyme_4_Signals:
1-27

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.1.1.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
6007641

# Metabolic_Enzyme_4_SwissProt_ID:
CLCF1_HUMAN (Q9UBD9)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CLCF1

# Metabolic_Enzyme_4_Geneatlas_id:
CLCF1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:17412

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_4_Gene_Sequence:
>678 bp
ATGGACCTCCGAGCAGGGGACTCGTGGGGGATGTTAGCGTGCCTGTGCACGGTGCTCTGG
CACCTCCCTGCAGTGCCAGCTCTCAATCGCACAGGGGACCCAGGGCCTGGCCCCTCCATC
CAGAAAACCTATGACCTCACCCGCTACCTGGAGCACCAACTCCGCAGCTTGGCTGGGACC
TATCTGAACTACCTGGGCCCCCCTTTCAACGAGCCAGACTTCAACCCTCCCCGCCTGGGG
GCAGAGACTCTGCCCAGGGCCACTGTTGACTTGGAGGTGTGGCGAAGCCTCAATGACAAA
CTGCGGCTGACCCAGAACTACGAGGCCTACAGCCACCTTCTGTGTTACTTGCGTGGCCTC
AACCGTCAGGCTGCCACTGCTGAGCTGCGCCGCAGCCTGGCCCACTTCTGCACCAGCCTC
CAGGGCCTGCTGGGCAGCATTGCGGGCGTCATGGCAGCTCTGGGCTACCCACTGCCCCAG
CCGCTGCCTGGGACTGAACCCACTTGGACTCCTGGCCCTGCCCACAGTGACTTCCTCCAG
AAGATGGACGACTTCTGGCTGCTGAAGGAGCTGCAGACCTGGCTGTGGCGCTCGGCCAAG
GACTTCAACCGGCTCAAGAAGAAGATGCAGCCTCCAGCAGCTGCAGTCACCCTGCACCTG
GGGGCTCATGGCTTCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF176911

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_4_Locus:
11q13.3

# Metabolic_Enzyme_4_SNPs:
rs867193; rs4930197; rs1790738; rs3781941; rs3781942; rs11826923; rs11227780; rs1638569; rs1790737; rs12788752; rs1790739; rs1790740; rs3758943; rs34057094; rs35896036; rs35385218; rs35544864; rs4024257; rs3837414; rs35112616; rs885763; rs35983106; rs5792415; rs10578684; rs34865354; rs10666079; rs12790741; rs5792414; rs885764; rs34198998; rs3837416; rs35361219; rs34641131; rs10666811; rs35573072; rs3837415; rs34550280; rs7484118; rs35764861; rs4320957; rs11227779; rs11227778; rs12222500; rs12288324; rs1419861; rs1638566; rs1638567; rs1638570; rs1638571; rs1638572; rs1790731; rs1790735; rs34087937; rs34468513; rs35176549; rs3909168; rs4930198; rs869154

# Metabolic_Enzyme_4_General_References:
10500198; 10448081

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5285

# Metabolic_Enzyme_5_Name:
Acyl-protein thioesterase 1

# Metabolic_Enzyme_5_Synonyms:
Lysophospholipase 1; Lysophospholipase I

# Metabolic_Enzyme_5_Gene_Name:
LYPLA1

# Metabolic_Enzyme_5_Protein_Sequence:
>Acylprotein thioesterase 1
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRP
VTLNMNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQ
GGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLM
FGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID

# Metabolic_Enzyme_5_Number_of_Residues:
230

# Metabolic_Enzyme_5_Molecular_Weight:
24670

# Metabolic_Enzyme_5_Theoretical_pI:
6.77

# Metabolic_Enzyme_5_GO_Classification:
Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Also has low lysophospholipase activity

# Metabolic_Enzyme_5_Pathway:
Not Available

# Metabolic_Enzyme_5_Reaction:
Not Available

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF02230:Abhydrolase_2

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.1.1.5

# Metabolic_Enzyme_5_GenBank_ID_Protein:
3415123

# Metabolic_Enzyme_5_SwissProt_ID:
LYPA1_HUMAN (O75608)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
LYPLA1

# Metabolic_Enzyme_5_Geneatlas_id:
LYPLA1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:6737

# Metabolic_Enzyme_5_PDB_ID:
1FJ2

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>693 bp
ATGTGCGGCAATAACATGTCAACCCCGCTGCCCGCCATCGTGCCCGCCGCCCGGAAGGCC
ACCGCTGCGGTGATTTTCCTGCATGGATTGGGAGATACTGGGCACGGATGGGCAGAAGCC
TTTGCAGGTATCAGAAGTTCACATATCAAATATATCTGCCCGCATGCGCCTGTTAGGCCT
GTTACATTAAATATGAACGTGGCTATGCCTTCATGGTTTGATATTATTGGGCTTTCACCA
GATTCACAGGAGGATGAATCTGGGATTAAACAGGCAGCAGAAAATATAAAAGCTTTGATT
GATCAAGAAGTGAAGAATGGCATTCCTTCTAACAGAATTATTTTGGGAGGGTTTTCTCAG
GGAGGAGCTTTATCTTTATATACTGCCCTTACCACACAGCAGAAACTGGCAGGTGTCACT
GCACTCAGTTGCTGGCTTCCACTTCGGGCTTCCTTTCCACAGGGTCCTATCGGTGGTGCT
AATAGAGATATTTCTATTCTCCAGTGCCACGGGGATTGTGACCCTTTGGTTCCCCTGATG
TTTGGTTCTCTTACGGTGGAAAAACTAAAAACATTGGTGAATCCAGCCAATGTGACCTTT
AAAACCTATGAAGGTATGATGCACAGTTCGTGTCAACAGGAAATGATGGATGTCAAGCAA
TTCATTGATAAACTCCTACCTCCAATTGATTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AF081281

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_5_Locus:
8q11.23

# Metabolic_Enzyme_5_SNPs:
rs16919923; rs6473905; rs8822; rs4737486; rs4506187; rs7829394; rs6473908; rs6983694; rs11998000; rs7003793; rs7844299; rs11994629; rs4737485; rs6473907; rs7008593; rs11986605; rs7463083; rs16919753; rs7007031; rs10504160; rs10112111; rs11988830; rs2037068; rs10101097; rs11988859; rs11775545; rs16919924; rs4737479; rs7011379; rs16919750; rs11993367; rs7839276; rs11549451; rs4310181; rs4486181; rs1044691; rs35038027; rs1044604; rs11549452; rs11549447; rs11549455; rs4475455; rs11549454; rs36051350; rs35130790; rs7005653; rs7836760; rs13269916; rs34705172; rs34207117; rs34578596; rs34866895; rs35292579; rs34317314; rs13279277; rs7820688; rs13275711; rs13269847; rs28369337; rs34967619; rs36030049; rs34232589; rs4737480; rs13279284; rs10090273; rs11780155; rs13265668; rs34599244; rs12019384; rs13259254; rs13259230; rs7815998; rs10101967; rs4427146; rs13269571; rs7833336; rs3054305; rs28452332; rs35231924; rs28749838; rs13276007; rs34951751; rs35405582; rs35023326; rs4480103; rs35882577; rs28813536; rs7001391; rs34805415; rs7001356; rs35772548; rs11994366; rs34478960; rs7004430; rs28437156; rs7822750; rs35162856; rs13250609; rs35188512; rs28397021; rs13277892; rs35318714; rs11992220; rs28533970; rs9643481; rs12056824; rs34135278; rs13263441; rs12676310; rs35672696; rs5891512; rs11288082; rs10958395; rs5891513; rs13262695; rs7357559; rs1828835; rs6981386; rs3054289; rs34828721; rs13269238; rs35106127; rs35890246

# Metabolic_Enzyme_5_General_References:
11080636; 11042152

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5293

# Metabolic_Enzyme_6_Name:
Galactoside-binding soluble lectin 13

# Metabolic_Enzyme_6_Synonyms:
Placental tissue protein 13; Placenta protein 13; PP13; Galectin-13

# Metabolic_Enzyme_6_Gene_Name:
LGALS13

# Metabolic_Enzyme_6_Protein_Sequence:
>Galactosidebinding soluble lectin 13
MSSLPVPYKLPVSLSVGSCVIIKGTPIHSFINDPQLQVDFYTDMDEDSDIAFRFRVHFGN
HVVMNRREFGIWMLEETTDYVPFEDGKQFELCIYVHYNEYEIKVNGIRIYGFVHRIPPSF
VKMVQVSRDISLTSVCVCN

# Metabolic_Enzyme_6_Number_of_Residues:
139

# Metabolic_Enzyme_6_Molecular_Weight:
16119

# Metabolic_Enzyme_6_Theoretical_pI:
5.53

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Has lysophospholipase activity

# Metabolic_Enzyme_6_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_6_Reaction:
2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00337:Gal-bind_lectin

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.1.1.5

# Metabolic_Enzyme_6_GenBank_ID_Protein:
6650760

# Metabolic_Enzyme_6_SwissProt_ID:
PP13_HUMAN (Q9UHV8)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
LGALS13

# Metabolic_Enzyme_6_Geneatlas_id:
LGALS13

# Metabolic_Enzyme_6_hgnc_id:
HGNC:15449

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>420 bp
ATGTCTTCTTTACCCGTGCCATACAAACTGCCTGTGTCTTTGTCTGTTGGTTCCTGCGTG
ATAATCAAAGGGACACCAATCCACTCTTTTATCAATGACCCACAGCTGCAGGTGGATTTC
TACACTGACATGGATGAGGATTCAGATATTGCCTTCCGTTTCCGAGTGCACTTTGGCAAT
CATGTGGTCATGAACAGGCGTGAGTTTGGGATATGGATGTTGGAGGAGACAACAGACTAC
GTGCCCTTTGAGGATGGCAAACAATTTGAGCTGTGCATCTACGTACATTACAATGAGTAT
GAGATAAAGGTCAATGGCATACGCATTTACGGCTTTGTCCATCGAATCCCGCCATCATTT
GTGAAGATGGTGCAAGTGTCGAGAGATATCTCCCTGACCTCAGTGTGTGTCTGCAATTGA


# Metabolic_Enzyme_6_GenBank_ID_Gene:
AF117383

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_6_Locus:
19q13.1

# Metabolic_Enzyme_6_SNPs:
rs2158964; rs2233706; rs2233709; rs17795657; rs1986156; rs1014206; rs3764844; rs2233708; rs12610294; rs3764843; rs10409099; rs11881603; rs2233711; rs1801654; rs2233710; rs2233707; rs9917050; rs28445525; rs12978134; rs10426654; rs2233703; rs35552633; rs3764842; rs2233704; rs2233705; rs2233702; rs10408486; rs10412234; rs10412744; rs10414890; rs10424213; rs10426515; rs10500280; rs11881743; rs12980535; rs12981089; rs12985936; rs2215004; rs4802044; rs6508877; rs6508878; rs682287; rs7245819; rs7251429; rs7259935; rs8106020

# Metabolic_Enzyme_6_General_References:
10527825; 6856484

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5299

# Metabolic_Enzyme_7_Name:
Eosinophil lysophospholipase

# Metabolic_Enzyme_7_Synonyms:
Charcot-Leyden crystal protein; Lysolecithin acylhydrolase; CLC; Galectin-10

# Metabolic_Enzyme_7_Gene_Name:
CLC

# Metabolic_Enzyme_7_Protein_Sequence:
>Eosinophil lysophospholipase
MSLLPVPYTEAASLSTGSTVTIKGRPLVCFLNEPYLQVDFHTEMKEESDIVFHFQVCFGR
RVVMNSREYGAWKQQVESKNMPFQDGQEFELSISVLPDKYQVMVNGQSSYTFDHRIKPEA
VKMVQVWRDISLTKFNVSYLKR

# Metabolic_Enzyme_7_Number_of_Residues:
142

# Metabolic_Enzyme_7_Molecular_Weight:
16481

# Metabolic_Enzyme_7_Theoretical_pI:
7.50

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
May have both lysophospholipase and carbohydrate-binding activities

# Metabolic_Enzyme_7_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_7_Reaction:
2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00337:Gal-bind_lectin

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.1.1.5

# Metabolic_Enzyme_7_GenBank_ID_Protein:
187274

# Metabolic_Enzyme_7_SwissProt_ID:
LPPL_HUMAN (Q05315)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
CLC

# Metabolic_Enzyme_7_Geneatlas_id:
CLC

# Metabolic_Enzyme_7_hgnc_id:
HGNC:2014

# Metabolic_Enzyme_7_PDB_ID:
1QKQ

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Note=Localized in granules from where it may be secreted or transported to other locations in the cell

# Metabolic_Enzyme_7_Gene_Sequence:
>429 bp
ATGTCCCTGCTACCCGTGCCATACACAGAGGCTGCCTCTTTGTCTACTGGTTCTACTGTG
ACAATCAAAGGGCGACCACTTGTCTGTTTCTTGAATGAACCATATCTGCAGGTGGATTTC
CACACTGAGATGAAGGAGGAATCAGACATTGTCTTCCATTTCCAAGTGTGCTTTGGTCGT
CGTGTGGTCATGAACAGCCGTGAGTATGGGGCCTGGAAGCAGCAGGTGGAATCCAAGAAC
ATGCCCTTTCAGGATGGCCAAGAATTTGAACTGAGCATCTCAGTGCTGCCAGATAAGTAC
CAGGTAATGGTCAATGGCCAATCCTCTTACACCTTTGACCATAGAATCAAGCCTGAGGCT
GTGAAGATGGTGCAAGTGTGGAGAGATATCTCCCTGACCAAATTTAATGTCAGCTATTTA
AAGAGATAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
L01664

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_7_Locus:
19q13.1

# Metabolic_Enzyme_7_SNPs:
rs17608; rs384138; rs44049; rs400233; rs367788; rs2238678; rs395892; rs44048; rs364911; rs373449; rs2074926; rs385520; rs446425; rs372902; rs391660; rs7253094; rs396854; rs1985359; rs367529; rs378917; rs437780; rs399641; rs372081; rs385288; rs444963; rs12611412; rs453827; rs383768; rs17709471; rs385240; rs10402365; rs389708; rs375867; rs388648; rs444817; rs391646; rs367156; rs395969; rs390406; rs414423; rs4802054; rs420297; rs2074928; rs431329; rs407640; rs447034; rs425218; rs428007; rs12611334; rs440191; rs7248113; rs7248344; rs7260274; rs425265; rs412211; rs413216; rs1034995; rs12463284; rs375688; rs10407799; rs7249415; rs7249847; rs12977184; rs12977467; rs34365053; rs34895925; rs12978411; rs12978659; rs12978243; rs104734; rs10636410; rs28439433; rs10636409; rs7249381; rs36043907; rs368009; rs34256647; rs34848185; rs34788009; rs2074927; rs375580; rs34953733; rs34190066; rs12980270; rs10408284; rs12979750; rs391333; rs444844; rs7249657; rs9676700; rs12978155; rs12979261; rs35837917; rs28595535; rs2159137; rs403831; rs7260191; rs2108685; rs5828049; rs1034996; rs7258913; rs8101720; rs35110762; rs1034867; rs1034868; rs10402500; rs10409161; rs10421474; rs10422830; rs16973596; rs2108686; rs2355335; rs385563; rs385895; rs410034; rs412884; rs4141230; rs4141231; rs418664; rs440334

# Metabolic_Enzyme_7_General_References:
8419478; 1577491; 9119387; 8747464; 10529229

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
8405

# Metabolic_Enzyme_8_Name:
Hypothetical protein

# Metabolic_Enzyme_8_Synonyms:
Not Available

# Metabolic_Enzyme_8_Gene_Name:
Not Available

# Metabolic_Enzyme_8_Protein_Sequence:
>Hypothetical protein
MLFKAYMYLNEGQKLLKTLKKDKSWSQTFESATFYSLKGEVCFNMGQIVLAKKMLRKALK
LLNRIFPYNLISLFLHIHVEKNRHFHYVNRQAQESPPPGKKRLAQLYRQTVCLSLLWRIY
SYSYLFHCKYYAHLAVMMQMNTALETQNCFQIIKAYLDYSLYHHLAGYKGVWFKYEVMAM
EHIFNLPLKGEGIEIVAYVAETLVFNKLIMGHLDLAIELGSRALQMWALLQNPNRHYQSL
CRLSRCLLLNSRYPQLIQVLGRLWELSVTQEHIFSKAFFYFVCLDILLYSGFVYRTFEEC
LEFIHQYENNRILKFHSGLLLGLYSSVAIWECEAGVGRRLHTSRDPGMPDFRNGTTFTNF
PIELKIFCQEEP

# Metabolic_Enzyme_8_Number_of_Residues:
372

# Metabolic_Enzyme_8_Molecular_Weight:
43901

# Metabolic_Enzyme_8_Theoretical_pI:
9.26

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
Not Available

# Metabolic_Enzyme_8_Pathway:
Not Available

# Metabolic_Enzyme_8_Reaction:
Not Available

# Metabolic_Enzyme_8_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 4.6.1.1

# Metabolic_Enzyme_8_GenBank_ID_Protein:
4153951

# Metabolic_Enzyme_8_SwissProt_ID:
O95558_HUMAN (O95558)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
Not Available

# Metabolic_Enzyme_8_Geneatlas_id:
Not Available

# Metabolic_Enzyme_8_hgnc_id:
Not Available

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Not Available

# Metabolic_Enzyme_8_Gene_Sequence:
>1119 bp
ATGCTGTTCAAGGCATACATGTATTTGAATGAAGGACAGAAGTTGCTAAAAACTCTCAAG
AAGGACAAATCTTGGAGCCAGACATTTGAGTCTGCCACCTTTTACAGCCTCAAAGGTGAG
GTCTGTTTCAATATGGGCCAGATAGTGCTTGCCAAGAAAATGCTGAGGAAGGCACTGAAG
CTCCTCAACCGAATCTTTCCTTACAACTTAATCTCCTTGTTTCTCCATATCCATGTCGAG
AAAAACAGACACTTTCATTATGTGAATCGGCAGGCCCAAGAGAGCCCACCTCCAGGGAAG
AAGAGGCTGGCACAACTTTACCGGCAAACTGTCTGCCTTTCCTTGCTGTGGCGCATCTAT
AGCTACAGTTATCTTTTTCACTGCAAGTATTATGCCCACCTGGCAGTTATGATGCAAATG
AATACTGCACTGGAAACTCAAAATTGTTTCCAGATCATTAAGGCTTACCTAGACTATTCG
CTATACCACCACCTGGCTGGCTACAAAGGTGTGTGGTTCAAATATGAAGTCATGGCCATG
GAGCACATCTTCAACCTCCCCCTGAAAGGCGAGGGCATTGAAATCGTGGCATACGTGGCT
GAGACACTGGTCTTCAACAAGCTCATAATGGGACACCTGGATTTGGCCATTGAGTTAGGC
TCCCGAGCCCTTCAGATGTGGGCACTGCTCCAGAATCCCAACCGACATTATCAGTCCCTC
TGCAGACTTAGCAGATGTCTCCTTCTGAACAGCAGATACCCGCAATTGATCCAGGTGCTG
GGGCGGCTGTGGGAGCTTTCTGTAACACAGGAACACATCTTCAGCAAGGCATTTTTCTAT
TTTGTCTGCTTGGACATCCTGCTTTATTCTGGTTTTGTTTATAGAACATTTGAAGAATGT
TTGGAATTCATACACCAATACGAAAACAACAGAATCCTCAAGTTCCACAGTGGACTCCTC
CTGGGACTTTATTCCTCTGTAGCTATCTGGGAGTGTGAAGCAGGGGTAGGCAGGAGACTA
CACACTTCCAGAGACCCAGGTATGCCAGACTTCAGGAATGGGACAACTTTTACAAATTTT
CCAATAGAGCTAAAAATCTTTTGCCAAGAAGAACCATGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
AL035122

# Metabolic_Enzyme_8_Chromosome_Location:
Not Available

# Metabolic_Enzyme_8_Locus:
Not Available

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
Not Available

# Metabolic_Enzyme_8_References:
7744860

# Metabolic_Enzyme_9_ID:
8447

# Metabolic_Enzyme_9_Name:
Sialidase-1 precursor

# Metabolic_Enzyme_9_Synonyms:
Lysosomal sialidase; N-acetyl- alpha-neuraminidase 1; Acetylneuraminyl hydrolase; G9 sialidase

# Metabolic_Enzyme_9_Gene_Name:
NEU1

# Metabolic_Enzyme_9_Protein_Sequence:
>Sialidase1 precursor
MTGERPSTALPDRRWGPRILGFWGGCRVWVFAAIFLLLSLAASWSKAENDFGLVQPLVTM
EQLLWVSGRQIGSVDTFRIPLITATPRGTLLAFAEARKMSSSDEGAKFIALRRSMDQGST
WSPTAFIVNDGDVPDGLNLGAVVSDVETGVVFLFYSLCAHKAGCQVASTMLVWSKDDGVS
WSTPRNLSLDIGTEVFAPGPGSGIQKQREPRKGRLIVCGHGTLERDGVFCLLSDDHGASW
RYGSGVSGIPYGQPKQENDFNPDECQPYELPDGSVVINARNQNNYHCHCRIVLRSYDACD
TLRPRDVTFDPELVDPVVAAGAVVTSSGIVFFSNPAHPEFRVNLTLRWSFSNGTSWRKET
VQLWPGPSGYSSLATLEGSMDGEEQAPQLYVLYEKGRNHYTESISVAKISVYGTL

# Metabolic_Enzyme_9_Number_of_Residues:
415

# Metabolic_Enzyme_9_Molecular_Weight:
45468

# Metabolic_Enzyme_9_Theoretical_pI:
5.68

# Metabolic_Enzyme_9_GO_Classification:
Not Available

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
Catalyzes the removal of sialic acid (N-acetylneuramic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage

# Metabolic_Enzyme_9_Pathway:
map00511  N-Glycan degradation;
 map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_9_Reaction:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF02012:BNR

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
20-42

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 3.2.1.18

# Metabolic_Enzyme_9_GenBank_ID_Protein:
2773339

# Metabolic_Enzyme_9_SwissProt_ID:
NEUR1_HUMAN (Q99519)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
NEU1

# Metabolic_Enzyme_9_Geneatlas_id:
NEU1

# Metabolic_Enzyme_9_hgnc_id:
HGNC:7758

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Lysosome; lysosomal membrane; peripheral membrane protein; lumenal side. Lysosome; lysosomal lumen. Cell membrane. Cytoplasmic vesicle. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles

# Metabolic_Enzyme_9_Gene_Sequence:
>1248 bp
ATGACTGGGGAGCGACCCAGCACGGCGCTCCCGGACAGACGCTGGGGGCCGCGGATTCTG
GGCTTCTGGGGAGGCTGTAGGGTTTGGGTGTTTGCCGCGATCTTCCTGCTGCTGTCTCTG
GCAGCCTCCTGGTCCAAGGCTGAGAACGACTTCGGTCTGGTGCAGCCGCTGGTGACCATG
GAGCAACTGCTGTGGGTGAGCGGGAGACAGATCGGCTCAGTGGACACCTTCCGCATCCCG
CTCATCACAGCCACTCCGCGGGGCACTCTTCTCGCCTTTGCTGAGGCGAGGAAAATGTCC
TCATCCGATGAGGGGGCCAAGTTCATCGCCCTGCGGAGGTCCATGGACCAGGGCAGCACA
TGGTCTCCTACAGCGTTCATTGTCAATGATGGGGATGTCCCCGATGGGCTGAACCTTGGG
GCAGTAGTGAGCGATGTTGAGACAGGAGTAGTATTTCTTTTCTACTCCCTTTGTGCTCAC
AAGGCCGGCTGCCAGGTGGCCTCTACCATGTTGGTATGGAGCAAGGATGATGGTGTTTCC
TGGAGCACACCCCGGAATCTCTCCCTGGATATTGGCACTGAAGTGTTTGCCCCTGGACCG
GGCTCTGGTATTCAGAAACAGCGGGAGCCACGGAAGGGCCGCCTCATCGTGTGTGGCCAT
GGGACGCTGGAGCGGGACGGAGTCTTCTGTCTCCTCAGCGATGATCATGGTGCCTCCTGG
CGCTACGGAAGTGGGGTCAGCGGCATCCCCTACGGTCAGCCCAAGCAGGAAAATGATTTC
AATCCTGATGAATGCCAGCCCTATGAGCTCCCAGATGGCTCAGTCGTCATCAATGCCCGA
AACCAGAACAACTACCACTGCCACTGCCGAATTGTCCTCCGCAGCTATGATGCCTGTGAT
ACACTAAGGCCCCGTGATGTGACCTTCGACCCTGAGCTCGTGGACCCTGTGGTAGCTGCA
GGAGCTGTAGTCACCAGCTCCGGCATTGTCTTCTTCTCCAACCCAGCACATCCAGAGTTC
CGAGTGAACCTGACCCTGCGATGGAGCTTCAGCAATGGTACCTCATGGCGGAAAGAGACA
GTCCAGCTATGGCCAGGCCCCAGTGGCTATTCATCCCTGGCAACCCTGGAGGGCAGCATG
GATGGAGAGGAGCAGGCCCCCCAGCTCTACGTCCTGTATGAGAAAGGCCGGAACCACTAC
ACAGAGAGCATCTCCGTGGCCAAAATCAGTGTCTATGGGACACTCTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AF040958

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_9_Locus:
6p21.3

# Metabolic_Enzyme_9_SNPs:
Not Available

# Metabolic_Enzyme_9_General_References:
8985184; 9020182; 9054950; 9480870; 10767332; 11063730; 10944856; 11279074

# Metabolic_Enzyme_9_References:
2649154

# Macromolecular_Interacting_Partner_1_ID:
7549

# Macromolecular_Interacting_Partner_1_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
INS

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_1_Signals:
1-24

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
INS

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11p15.5

# Macromolecular_Interacting_Partner_1_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_1_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_1_References:
1846542; 2674135; 2849433

# Macromolecular_Interacting_Partner_2_ID:
7061

# Macromolecular_Interacting_Partner_2_Name:
Ganglioside GM2 activator precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
GM2-AP; Cerebroside sulfate activator protein; Shingolipid activator protein 3; SAP-3[Contains: Ganglioside GM2 activator isoform short]

# Macromolecular_Interacting_Partner_2_Gene_Name:
GM2A

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Ganglioside GM2 activator precursor
MQSLMQAPLLIALGLLLATPAQAHLKKPSQLSSFSWDNCDEGKDPAVIRSLTLEPDPIVV
PGNVTLSVVGSTSVPLSSPLKVDLVLEKEVAGLWIKIPCTDYIGSCTFEHFCDVLDMLIP
TGEPCPEPLRTYGLPCHCPFKEGTYSLPKSEFVVPDLELPSWLTTGNYRIESVLSSSGKR
LGCIKIAASLKGI

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
193

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
20822

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
4.96

# Macromolecular_Interacting_Partner_2_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Signals:
1-23

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
183357

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
SAP3_HUMAN (P17900)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
GM2A

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
GM2A

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:4367

# Macromolecular_Interacting_Partner_2_PDB_ID:
1PU5

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Lysosome

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>582 bp
ATGCAGTCCCTGATGCAGGCTCCCCTCCTGATCGCCCTGGGCTTGCTTCTCGCGGCCCCT
GCGCAAGCCCACCTGAAAAAGCCATCCCAGCTCAGTAGCTTTTCCTGGGATAACTGTGAT
GAAGGGAAGGACCCTGCGGTGATCAGAAGCCTGACTCTGGAGCCTGACCCCATCGTCGTT
CCTGGAAATGTGACCCTCAGTGTCGTGGGCAGCACCAGTGTCCCCCTGAGTTCTCCTCTG
AAGGTGGATTTAGTTTTGGAGAAGGAGGTGGCTGGCCTCTGGATCAAGATCCCATGCACA
GACTACATTGGCAGCTGTACCTTTGAACACTTCTGTGATGTGCTTGACATGTTAATTCCT
ACTGGGGAGCCCTGCCCAGAGCCCCTGCGTACCTATGGGCTTCCTTGCCACTGTCCCTTC
AAAGAAGGAACCTACTCACTGCCCAAGAGCGAATTCGTTGTGCCTGACCTGGAGCTGCCC
AGTTGGCTCACCACCGGGAACTACCGCATAGAGAGCGTCCTGAGCAGCAGTGGGAAGCGT
CTGGGCTGCATCAAGATCGCTGCCTCTCTAAAGGGCATATAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M76477

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_2_Locus:
5q31.3-q33.1

# Macromolecular_Interacting_Partner_2_SNPs:
rs153477; rs153478; rs1048719; rs1048723; rs153450; rs9324685; rs2277028; rs9324686; rs989; rs149174; rs153479; rs248463; rs1004595; rs6861766; rs6579845; rs16838; rs248465; rs153476; rs12657307; rs152266; rs6896627; rs153473; rs2075783; rs17716141; rs2075782; rs248464; rs17659728; rs153481; rs248466; rs153474; rs6882156; rs6896500; rs746619; rs2277030; rs2277029; rs1006748; rs10039987; rs153480; rs17801974; rs253570; rs153449; rs12516391; rs3806953; rs153483; rs3806952; rs28365994; rs1048718; rs1130163; rs35295884; rs1048724; rs35982513; rs15860; rs35654352; rs11262; rs35568032; rs35550113; rs35055757; rs35558756; rs248467; rs999296; rs35663468; rs13186851; rs190336; rs41290575; rs35047331; rs33953379; rs5872196; rs6878463; rs6884764; rs34519111; rs34214150; rs35176969; rs2839733; rs153484; rs34750048; rs10076604; rs3756627; rs3834264; rs34066259; rs10059702; rs10076053; rs1065018; rs13155282; rs1469684; rs153445; rs153447; rs153482; rs17111892; rs17111894; rs17659864; rs17728915; rs17729018; rs17802052; rs2193931; rs248469; rs253566; rs6579843; rs6579844; rs7717132; rs7732049

# Macromolecular_Interacting_Partner_2_General_References:
2059210; 1915857; 1554364; 1427911; 10364519; 2753159; 2209618; 11090283; 1915858; 8244332; 8900233

# Macromolecular_Interacting_Partner_2_References:
9712817

# Macromolecular_Interacting_Partner_3_ID:
8080

# Macromolecular_Interacting_Partner_3_Name:
Beta-nerve growth factor precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
Beta-NGF

# Macromolecular_Interacting_Partner_3_Gene_Name:
NGFB

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Betanerve growth factor precursor
MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIA
ARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSK
RSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCR
DPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRR
A

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
241

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
26959

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
10.54

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00243:NGF

# Macromolecular_Interacting_Partner_3_Signals:
1-18

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
671883

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
NGF_HUMAN (P01138)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
NGFB

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
NGFB

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:7808

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>726 bp
ATGTCCATGTTGTTCTACACTCTGATCACAGCTTTTCTGATCGGCATACAGGCGGAACCA
CACTCAGAGAGCAATGTCCCTGCAGGACACACCATCCCCCAAGTCCACTGGACTAAACTT
CAGCATTCCCTTGACACTGCCCTTCGCAGAGCCCGCAGCGCCCCGGCAGCGGCGATAGCT
GCACGCGTGGCGGGGCAGACCCGCAACATTACTGTGGACCCCAGGCTGTTTAAAAAGCGG
CGACTCCGTTCACCCCGTGTGCTGTTTAGCACCCAGCCTCCCCGTGAAGCTGCAGACACT
CAGGATCTGGACTTCGAGGTCGGTGGTGCTGCCCCCTTCAACAGGACTCACAGGAGCAAG
CGGTCATCATCCCATCCCATCTTCCACAGGGGCGAATTCTCGGTGTGTGACAGTGTCAGC
GTGTGGGTTGGGGATAAGACCACCGCCACAGACATCAAGGGCAAGGAGGTGATGGTGTTG
GGAGAGGTGAACATTAACAACAGTGTATTCAAACAGTACTTTTTTGAGACCAAGTGCCGG
GACCCAAATCCCGTTGACAGCGGGTGCCGGGGCATTGACTCAAAGCACTGGAACTCATAT
TGTACCACGACTCACACCTTTGTCAAGGCGCTGACCATGGATGGCAAGCAGGCTGCCTGG
CGGTTTATCCGGATAGATACGGCCTGTGTGTGTGTGCTCAGCAGGAAGGCTGTGAGAAGA
GCCTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
V01511

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_3_Locus:
1p13.1

# Macromolecular_Interacting_Partner_3_SNPs:
rs6330; rs11466110; rs11466111; rs6325; rs1318345; rs2747058; rs719452; rs2179926; rs2254404; rs2856813; rs910330; rs2239622; rs10776800; rs2254527; rs3811015; rs4332358; rs10776798; rs4454548; rs4839028; rs4073129; rs4076194; rs4839435; rs4146585; rs6678788; rs4839436; rs6326; rs12082544; rs6328; rs6698675; rs7540561; rs6537860; rs4240542; rs7544068; rs4529705; rs7542555; rs4075872; rs11102929; rs2747063; rs10745349; rs7535026; rs10776799; rs2268792; rs6673867; rs4565713; rs4626883; rs2268793; rs4076018; rs2300692; rs6331; rs6686615; rs10858075; rs12402406; rs11466098; rs17540656; rs4573519; rs10858072; rs10489530; rs12060354; rs7516191; rs11466100; rs11102924; rs7530686; rs3730194; rs2856811; rs10776797; rs12026714; rs11102925; rs17033706; rs7513144; rs4298728; rs17033692; rs17033685; rs10442682; rs11102919; rs12067817; rs4382725; rs4567277; rs3738701; rs11102917; rs11466085; rs11102926; rs7544163; rs7523654; rs17033688; rs10858074; rs4634908; rs2300694; rs7520839; rs11466069; rs11466104; rs11466091; rs11466073; rs4240543; rs11466103; rs11466089; rs11466083; rs11466102; rs12026809; rs11102920; rs12145726; rs12048019; rs11466076; rs11102916; rs11466070; rs10442681; rs6678898; rs11466068; rs11466075; rs12061479; rs7415422; rs11466099; rs7555016; rs11466093; rs6658541; rs11466077; rs17033622; rs11466079; rs11466095; rs2300693; rs11466094; rs4623700; rs10858071; rs11466106; rs11466109; rs12058002; rs11466097; rs11466074; rs3811016; rs12061661; rs17033680; rs2300695; rs11466108; rs4644491; rs11102922; rs4406631; rs12058927; rs11466072; rs12091513; rs12060360; rs11466071; rs4298730; rs11466081; rs11466086; rs10858073; rs11466080; rs11102921; rs11102927; rs7536097; rs12760036; rs11102918; rs11466087; rs11466096; rs11466084; rs4320778; rs11584438; rs4348722; rs4456091; rs4839434; rs6329; rs7417254; rs11466088; rs10158276; rs4240544; rs11466082; rs3811014; rs10776801; rs11102930; rs11466113; rs11466066; rs11466063; rs11466065; rs11466062; rs34542615; rs28758211; rs11466112; rs34079702; rs35941329; rs11466092; rs12727497; rs35833423; rs11579116; rs35290932; rs11302114; rs2284830; rs12749420; rs3730184; rs28645283; rs2747059; rs11466090; rs35070942; rs11102923; rs12088144; rs35067920; rs11102928; rs11580846; rs35755250; rs11466107; rs34024301; rs12023088; rs28735771; rs28461336; rs11579131; rs34357271; rs34257515; rs11579114; rs35884898; rs12025459; rs12119346; rs35221274; rs35274060; rs12073677; rs12070188; rs11584424; rs35329343; rs34377570; rs11485078; rs3730215; rs35658308; rs3021067; rs4417063; rs12731678; rs2747061; rs35447405; rs12047130; rs11579133; rs13374803; rs35225488; rs9970214; rs719451; rs7528234; rs2747056; rs2856814; rs10157426; rs12731680; rs11466078; rs2747055; rs35917469; rs35011726; rs35337130; rs35044546; rs17033682; rs28505352; rs34063775; rs2856812; rs35439338; rs11466105; rs34845120; rs11586039; rs34042023; rs35071824; rs34402529; rs2747057; rs11466114; rs35603764; rs11466064; rs11466061; rs11466067; rs34611363; rs3841009; rs10776802; rs10858076; rs10858077; rs10858078; rs11102915; rs11102932; rs11466059; rs11583020; rs11805062; rs11807499; rs12074502; rs12075799; rs12085129; rs12139760; rs12723944; rs1474798; rs1535093; rs1555207; rs17033589; rs17033597; rs17033602; rs17033725; rs2068797; rs2982740; rs2982741; rs2982742; rs3014804; rs4073110; rs4131272; rs4131273; rs4310443; rs4418592; rs4504888; rs4839029; rs4839030; rs4839031; rs6327; rs6656381; rs6657711; rs6676284; rs6678944; rs6691765; rs7416420; rs7523086; rs7523831; rs7532754; rs7544256; rs926781

# Macromolecular_Interacting_Partner_3_General_References:
6688123; 6327169; 2374737; 10322959; 2025430; 10391209

# Macromolecular_Interacting_Partner_3_References:
10082272; 7539142; 9166727; 9748278

# Macromolecular_Interacting_Partner_4_ID:
8384

# Macromolecular_Interacting_Partner_4_Name:
Thy-1 membrane glycoprotein precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
Thy-1 antigen; CD90 antigen; CDw90 antigen

# Macromolecular_Interacting_Partner_4_Gene_Name:
THY1

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Thy1 membrane glycoprotein precursor
MNLAISIALLLTVLQVSRGQKVTSLTACLVDQSLRLDCRHENTSSSPIQYEFSLTRETKK
HVLFGTVGVPEHTYRSRTNFTSKYNMKVLYLSAFTSKDEGTYTCALHHSGHSPPISSQNV
TVLRDKLVKCEGISLLAQNTSWLLLLLLSLSLLQATDFMSL

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
161

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
17935

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.93

# Macromolecular_Interacting_Partner_4_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00047:ig

# Macromolecular_Interacting_Partner_4_Signals:
1-19

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
339683

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
THY1_HUMAN (P04216)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
THY1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
THY1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11801

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>486 bp
ATGAACCTGGCCATCAGCATCGCTCTCCTGCTAACAGTCTTGCAGGTCTCCCGAGGGCAG
AAGGTGACCAGCCTAACGGCCTGCCTAGTGGACCAGAGCCTTCGTCTGGACTGCCGCCAT
GAGAATACCAGCAGTTCACCCATCCAGTACGAGTTCAGCCTGACCCGTGAGACAAAGAAG
CACGTGCTCTTTGGCACTGTGGGGGTGCCTGAGCACACATACCGCTCCCGAACCAACTTC
ACCAGCAAATACCACATGAAGGTCCTCTACTTATCCGCCTTCACTAGCAAGGACGAGGGC
ACCTACACGTGTGCACTCCACCACTCTGGCCATTCCCCACCCATCTCCTCCCAGAACGTC
ACAGTGCTCAGAGACAAACTGGTCAAGTGTGAGGGCATCAGCCTGCTGGCTCAGAACACC
TCGTGGCTGCTGCTGCTCCTGCTGTCCCTCTCCCTCCTCCAGGCCACGGATTTCATGTCC
CTGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
M11749

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_4_Locus:
11q22.3-q23

# Macromolecular_Interacting_Partner_4_SNPs:
rs35922941; rs1054735; rs1001205; rs1429512; rs3138090; rs3138088; rs3138089; rs12291644; rs3751026; rs3138091; rs1894006; rs3138092; rs3138093; rs3910017; rs3138094; rs1864291; rs7130266; rs3862600; rs11574653; rs6589737; rs11605591; rs17122908; rs3138095; rs11546392; rs11546394; rs11546391; rs11574654; rs1055370; rs11546395; rs35968741; rs34221330; rs1055922; rs34445567; rs1064070; rs34842757; rs3834923; rs13770; rs34024712; rs12574900; rs4397862; rs35040118; rs34373320; rs2082050; rs1864290; rs34587031; rs9651689; rs11217274; rs11217278; rs11217279; rs11603909; rs12277306; rs12282662; rs12417523; rs12417550; rs12417611; rs12418314; rs12421120; rs12797564; rs12807216; rs2852368; rs34787647; rs576204; rs7102492; rs7102696; rs7119828; rs7939055; rs891293

# Macromolecular_Interacting_Partner_4_General_References:
2864690; 10944468; 7683034

# Macromolecular_Interacting_Partner_4_References:
11999340; 15034144; 304463

# Macromolecular_Interacting_Partner_5_ID:
7921

# Macromolecular_Interacting_Partner_5_Name:
Galectin-1

# Macromolecular_Interacting_Partner_5_Synonyms:
Lectin galactoside-binding soluble 1; Beta-galactoside- binding lectin L-14-I; Lactose-binding lectin 1; S-Lac lectin 1; Galaptin; 14 kDa lectin; HPL; HBL; Putative MAPK-activating protein MP12

# Macromolecular_Interacting_Partner_5_Gene_Name:
LGALS1

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Galectin1
MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIV
CNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINY
MAADGDFKIKCVAFD

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
135

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
14716

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
5.15

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
May regulate cell apoptosis and cell differentiation. Binds beta-galactoside. Binds CD45, CD3 and CD4. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00337:Gal-bind_lectin

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
34343

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
LEG1_HUMAN (P09382)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
LGALS1

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
LGALS1

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:6561

# Macromolecular_Interacting_Partner_5_PDB_ID:
1GZW

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>408 bp
ATGGCTTGTGGTCTGGTCGCCAGCAACCTGAATCTCAAACCTGGAGAGTGCCTTCGAGTG
CGAGGCGAGGTGGCTCCTGACGCTAAGAGCTTCGTGCTGAACCTGGGCAAAGACAGCAAC
AACCTGTGCCTGCACTTCAACCCTCGCTTCAACGCCCACGGCGACGCCAACACCATCGTG
TGCAACAGCAAGGACGGCGGGGCCTGGGGGACCGAGCAGCGGGAGGCTGTCTTTCCCTTC
CAGCCTGGAAGTGTTGCAGAGGTGTGCATCACCTTCGACCAGGCCAACCTGACCGTCAAG
CTGCCAGATGGATACGAATTCAAGTTCCCCAACCGCCTCAACCTGGAGGCCATCAACTAC
ATGGCAGCTGACGGTGACTTCAAGATCAAATGTGTGGCCTTTGACTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
X14829

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_5_Locus:
22q13.1

# Macromolecular_Interacting_Partner_5_SNPs:
rs9622680; rs9622682; rs12167604; rs4820294; rs4820293; rs929039; rs2071769; rs11539852; rs11539846; rs4887; rs11539856; rs3208174; rs11539850; rs11704758; rs11539847; rs1803902; rs4888; rs35767287; rs11539857; rs12251; rs11539854; rs34671258; rs35297059; rs12157867; rs9917591; rs9619701; rs9622681; rs12172389; rs34806296; rs5845352; rs3985986; rs9610829; rs13057866; rs7287759; rs35411985; rs41283239; rs35530306; rs34195652; rs11914203; rs13055131; rs2899292; rs3177075; rs4820295; rs5756764; rs6000861; rs6000862; rs713835; rs739139; rs743837; rs762990

# Macromolecular_Interacting_Partner_5_General_References:
2719964; 2910856; 2719646; 1988031; 12761501; 10591208; 3065332; 12665801; 3611046; 2383549; 7501023; 10369126; 10764829; 11146440

# Macromolecular_Interacting_Partner_5_References:
11451961; 16267866; 9556610

End of HMDB00117

Beginning of HMDB00118
# Accession_No:
HMDB00118

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-17 15:48:34

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Homovanillic acid

# Description:
A dopamine metabolite occurring in human biofluids. A high proportion of patients with neuroblastoma excrete increased amounts of it in their urine.
Homovanillic acid is a major catecholamine metabolite. It is used as a reagent to detect oxidative enzymes.(Wikipedia)

# Synonyms:
(4-Hydroxy-3-methoxyphenyl)acetate; (4-Hydroxy-3-methoxyphenyl)acetic acid; 3-methoxy-4-hydroxy-phenylacetic acid; 3-Methoxy-4-hydroxyphenylacetate; 3-Methoxy-4-hydroxyphenylacetic acid; 4-Hydroxy-3-methoxybenzeneacetate; 4-Hydroxy-3-methoxybenzeneacetic acid; 4-Hydroxy-3-methoxyphenylacetic acid;  Homovanilate; Homovanilic acid; Homovanillate; Homovanillinic acid;  Vanilacetate; Vanilacetic acid

# Chemical_IUPAC_Name:
2-(4-hydroxy-3-methoxy-phenyl)acetic acid

# Chemical_Formula:
C9H10O4

# Chemical_Structure:
tbl_chemical:::HMDB00118_ZOOM.png:::119283198108166080

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00118_THUMB.png:::119283197927661607

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Phenols; Aromatic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
phenol or hydroxyhetarene; alkyl aryl ether; carboxylic acid; aromatic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
182.05791

# Molecular_Weight_Avg:
182.17329

# Smiles_String_isomeric:
COC1=CC(CC(O)=O)=CC=C1O

# Smiles_String_canonical:
COC1=CC(CC(O)=O)=CC=C1O

# KEGG_Compound_ID:
C05582

# BioCyc_ID:
Not Available

# PubChem_CID:
1738

# PubChem_SID:
7908; 10410972; 8151265; 152580; 80195; 11111257; 4527131; 3136274; 8316; 10517916

# OMIM_ID:
168605

# Metagene_ID:
SEGAWA SYNDROME: 391; MONOAMINE OXIDASE-A DEFICIENCY (MAO-A): 446; SEPIAPTERIN REDUCTASE DEFICIENCY: 471; DOPA-RESPONSIVE DYSTONIA: 451; DOPAMINE BETA-HYDROXYLASE DEFICIENCY (DßH): 445; TYROSINE HYDROXYLASE DEFICIENCY: 439; AROMATIC L-AMINO ACID DECARBOXYLASE DEFICIENCY: 354; HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY: 133; HYPERPHENYLALANIEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY: 355

# BiGG_ID:
46066

# Wikipedia_ID:
Homovanillic acid

# METLIN_ID:
971

# Ref_ID:
8516085; 3797547; 2428421; 6085084; 9722142; 2939198; 2437853; 432666; 3000280; 2193315; 2644889; 8515683; 3263594; 1537368; 1712114; 2991966; 12891653; 15843212; 8087979; 2581293; 9849813; 16259647; 2604799; 2428259; 2409733; 8306920; 3400977; 8724671; 15652629; 8561958; 8884658; 2416192; 8945737; 9270904; 2702581; 9608578; 1901508; 115032; 11020122; 12615172; 2026685; 9732974; 9509499; 7524950; 9210210; 12649306; 1628216; 2742727; 16922197; 11710721; 9736322; 1166321; 3928811; 1257763; 1729408; 4039834; 3572399; 8729530; 7687150; 6198473; 1930613; 10331106

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
306-08-1

# InChI:
InChI=1/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12)

# Synthesis_Reference:
Not Available

# Melting_Point:
138-140 oC; 142 oC

# Melting_Point_predicted:
101.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
17 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
69.7 mg/mL [MEYLAN,WM et al. (1996)]; 2.72 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
0.33 [LAHANN,TR ET AL. (1989)]

# LogP_predicted:
1.02 [Predicted by ALOGPS]; 1 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Homovanillic acid.pdf:::1132562201761940132

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Homovanillic_acid.mol:::1132723808031472104

# SDF_File_[Text]:
tbl_chemical:::HMDB00118.sdf:::119283197589761193

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00118.pdb:::119283197789854985

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::050104_P00_04_IS_1DP_presat.png:::11527240686708126

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::050104_P00_04_IS_1DP_presat_1.zip:::114720991159044020

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::050104_P00_04_IS_1DP_Assigned.png:::114850876259761673

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050104_P00_04_IS_2DHSQC_824.png:::1148058798582654

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050104_P00_04_IS_2DHSQC_824.zip:::11480587985889466

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050104_P00_04_IS_2DHSQC_824_Assigned.png:::116249107181893175

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Homovanillic acid.gif:::1132732110171480317

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00118_peaks.txt:::115630955444715031

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Homovanillic acid_C.gif:::1132737688302580334

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00118_peaks.txt:::1156310744589669757

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00118L.png:::117555263355477760; Medium Energy:tbl_ms:::HMDB00118M.png:::117555268562431582; High Energy:tbl_ms:::HMDB00118H.png:::117555271891578895

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000132.png:::11690744409375985

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000132.txt:::116907444093729282

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000132.png:::116890828314049016

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000132.txt:::116890828339051276

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Brain; Caudate Nucleus; Central Nervous System; Fibroblasts; Kidneys; Spinal Cord; Striatum

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Urine	17.1	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	8087979
Urine	20.6	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	8087979
Urine	9.2	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	7.5	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	5.6	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	8087979
Urine	<=3.618	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Merck Manual
Urine	2.2 (0.4-4.0)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	7524950
Urine	4.93 +/- 3.37	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	2026685
Urine	10.9	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	3400977
Blood	0.082 +/- 0.050	umol/L	Adult:>18_yrs_old	Both	Normal	2480613
Blood	0.07	umol/L	Adult:>18_yrs_old	Both	Normal	12649306
Cerebrospinal_Fluid(CSF)	0.12 +/- 0.07	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	0.19+/- 0.093	uM	Adult:>18_yrs_old	N/A	Normal	7872875
Cerebrospinal_Fluid(CSF)	0.28 (0.15-0.41)	uM	Adolescent:13-18_yrs_old	Both	Normal	15652629
Cerebrospinal_Fluid(CSF)	0.0004 +/- 0.00006 	uM	Adult:>18_yrs_old	Male	Normal	8884658 
Cerebrospinal_Fluid(CSF)	0.89 +/- 0.47	umol/L	Infant:0-1_yr_old	N/A	Normal	9732974
Cerebrospinal_Fluid(CSF)	0.78 +/- 0.42	umol/L	Children:1-13_yrs_old	N/A	Normal	9732974
Cerebrospinal_Fluid(CSF)	0.76 +/- 0.38	umol/L	Children:1-13_yrs_old	N/A	Normal	9732974
Cerebrospinal_Fluid(CSF)	0.71 +/- 0.34	umol/L	Children:1-13_yrs_old	N/A	Normal	9732974
Cerebrospinal_Fluid(CSF)	0.66 +/- 0.33	umol/L	Infant:0-1_yr_old	N/A	Normal	9732974
Cerebrospinal_Fluid(CSF)	0.66 +/- 0.48	umol/L	Children:1-13_yrs_old	N/A	Normal	9732974
Cerebrospinal_Fluid(CSF)	0.54 +/- 0.211	umol/L	Adolescent:13-18_yrs_old	N/A	Normal	9732974
Cerebrospinal_Fluid(CSF)	0.37 +/- 0.08	umol/L	Adolescent:13-18_yrs_old	N/A	Normal	9732974
Cerebrospinal_Fluid(CSF)	1.14 +/- 0.54	umol/L	Newborn:0-30_days_old	N/A	Normal	9732974
Cerebrospinal_Fluid(CSF)	0.14 +/- 0.046	umol/L	Adult:>18_yrs_old	N/A	Normal	1712114
Cerebrospinal_Fluid(CSF)	0.40 +/- 0.075	umol/L	Adult:>18_yrs_old	N/A	Normal	7687150
Cerebrospinal_Fluid(CSF)	0.039 +/- 0.021	umol/L	Adult:>18_yrs_old	N/A	Normal	6085084
Cerebrospinal_Fluid(CSF)	0.174 +/- 0.075	umol/L	Adult:>18_yrs_old	Male	Normal	6198473
Cerebrospinal_Fluid(CSF)	0.202 +/- 0.094	umol/L	Adult:>18_yrs_old	Female	Normal	6198473
Cerebrospinal_Fluid(CSF)	0.94 +/- 0.11 	umol/L	Children:1-13_yrs_old	N/A	Normal	803305
Cerebrospinal_Fluid(CSF)	0.20 (0.047-0.35)	umol/L	Adult:>18_yrs_old	Both	Normal	16259647


# Concentration_[Abnormal]:
Blood	0.0623 +/- 0.022	umol/L	Adult:>18_yrs_old	Male	schizophrenic patient (Male)	2480613
Blood	0.0711 +/- 0.022	umol/L	Adult:>18_yrs_old	Female	Schizophrenic patients (Women)	2480613
Cerebrospinal_Fluid(CSF)	0.49 +/- 0.08 	uM	Children:1-13_yrs_old	Both	Epilepsy	803305
Cerebrospinal_Fluid(CSF)	0.39 +/- 0.091	umol/L	Adult:>18_yrs_old	N/A	Narcolepsy	8945737
Cerebrospinal_Fluid(CSF)	0.21 +/- 0.08	umol/L	Adult:>18_yrs_old	N/A	GH Deficiency	8729530
Cerebrospinal_Fluid(CSF)	0.21 +/- 0.035 	umol/L	Adult:>18_yrs_old	Female	Schizophrenic patients after treatment with ETC	115032
Cerebrospinal_Fluid(CSF)	0.19 +/- 0.030 	umol/L	Adult:>18_yrs_old	Female	Schizophrenic patients	115032
Cerebrospinal_Fluid(CSF)	0.21 +/- 0.12 	uM	Adult:>18_yrs_old	N/A	Epilepsy with low thiamine	1705463
Cerebrospinal_Fluid(CSF)	0.05 +/- 0.03 	uM	Adult:>18_yrs_old	N/A	Epilepsy with cerebellar and cerebral atrophy	1705463
Cerebrospinal_Fluid(CSF)	0.05 +/- 0.04 	uM	Adult:>18_yrs_old	Both	Epilepsy not treated with phenytoin	1705463
Cerebrospinal_Fluid(CSF)	0.19 +/- 0.09 	uM	Adult:>18_yrs_old	N/A	Epilepsy with low folate	1705463
Cerebrospinal_Fluid(CSF)	0.20 +/- 0.09 	uM	Adult:>18_yrs_old	Both	Major depression	9004051 
Cerebrospinal_Fluid(CSF)	0.17 +/- 0.084	umol/L	Adult:>18_yrs_old	N/A	Panic Disorder	1712114
Cerebrospinal_Fluid(CSF)	0.16 +/- 0.095 	uM	Elderly:>65_yrs_old	N/A	Parkinson's disease	1436520
Cerebrospinal_Fluid(CSF)	0.17 +/- 0.01 	uM	Adult:>18_yrs_old	N/A	Olivopontocerebral Atrophy	11383938
Cerebrospinal_Fluid(CSF)	0.17 +/- 0.01 	uM	N/A	N/A	Friedrich's Ataxia	11383938
Cerebrospinal_Fluid(CSF)	0.15 +/- 0.03 	uM	Adult:>18_yrs_old	N/A	Spastic Ataxia	11383938
Cerebrospinal_Fluid(CSF)	0.50 +/- 0.32	umol/L	Children:1-13_yrs_old	N/A	Autism	7687150
Cerebrospinal_Fluid(CSF)	0.0002 +/- 0.00005 	uM	Adult:>18_yrs_old	Both	Hypothyroid patients	9849813 
Cerebrospinal_Fluid(CSF)	0.00017 (0.00013-0.00022)	umol/L	Adult:>18_yrs_old	Both	Hypothyroidism	9849813


# Associated_Disorders:
Alzheimer's Disease; Autism; Autistism; Cocaine Exposure; Cognitive Disorders; Down's syndrome; Down's syndrome(<35 years old); Epilepsy; Epilepsy not treated with phenytoin; Epilepsy treated with phenytoin (after Intoxication); Epilepsy treated with phenytoin (Intoxicated); Epilepsy treated with phenytoin (well controlled); Epilepsy with borderline folate; Epilepsy with borderline thiamine; Epilepsy with cerebellar and cerebral atrophy; Epilepsy with cerebellar atrophy; Epilepsy with low folate; Epilepsy with low thiamine; Epilepsy with no CNS atrophy; Friedrich's Ataxia; GH Deficiency; GTP cyclohydroxylase-I (GTP-CH) Deficiency; Hypothyroid patients; Hypothyroidism; major depression; Narcolepsy; Neuroblastoma; Olivopontocerebral Atrophy; Opsoclonus-myoclonus; Panic Disorder; Parkinson's disease; Schizophrenia; schizophrenic patient (Male); Schizophrenic patients; Schizophrenic patients (Women); Schizophrenic patients after treatment with ETC; Sepiapterin Reductase Deficiency; Spastic Ataxia; Subarachnoid Haemorrhage; Tyrosine Hydroxylase (TH) Deficiency

# Pathway_Names:
Pyruvate metabolism;Glyoxylate and dicarboxylate metabolism

# Pathway_Images:
;

# KEGG_Images:
map00620;map00630

# Pathway_Graphs:
;

# Pathway_SBMLs:
;

# Metabolic_Enzyme_1_ID:
5628

# Metabolic_Enzyme_1_Name:
Glyoxylate reductase/hydroxypyruvate reductase

# Metabolic_Enzyme_1_Synonyms:
Not Available

# Metabolic_Enzyme_1_Gene_Name:
GRHPR

# Metabolic_Enzyme_1_Protein_Sequence:
>Glyoxylate reductase/hydroxypyruvate reductase
MRPVRLMKVFVTRRIPAEGRVALARAADCEVEQWDSDEPIPAKELERGVAGAHGLLCLLS
DHVDKRILDAAGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLL
TTCRRLPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRF
LYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVF
INISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIGSATHR
TRNTMSLLAANNLLAGLRGEPMPSELKL

# Metabolic_Enzyme_1_Number_of_Residues:
328

# Metabolic_Enzyme_1_Molecular_Weight:
35669

# Metabolic_Enzyme_1_Theoretical_pI:
7.44

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  L-serine metabolism
Process:  L-serine biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities

# Metabolic_Enzyme_1_Pathway:
map00620  Pyruvate metabolism;
 map00630  Glyoxylate and dicarboxylate metabolism

# Metabolic_Enzyme_1_Reaction:
glycolate + NADP+ = glyoxylate + NADPH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00389:2-Hacid_dh;
PF02826:2-Hacid_dh_C

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.1.1.79

# Metabolic_Enzyme_1_GenBank_ID_Protein:
6002730

# Metabolic_Enzyme_1_SwissProt_ID:
GRHPR_HUMAN (Q9UBQ7)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
GRHPR

# Metabolic_Enzyme_1_Geneatlas_id:
GRHPR

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4570

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>987 bp
ATGAGACCGGTGCGACTCATGAAGGTGTTCGTCACCCGCAGGATACCCGCCGAGGGTAGG
GTCGCGCTCGCCCGGGCGGCAGACTGTGAGGTGGAGCAGTGGGACTCGGATGAGCCCATC
CCTGCCAAGGAGCTAGAGCGAGGTGTGGCGGGGGCCCACGGCCTGCTCTGCCTCCTCTCC
GACCACGTGGACAAGAGGATCCTGGATGCTGCAGGGGCCAATCTCAAAGTCATCAGCACC
ATGTCTGTGGGCATCGACCACTTGGCTTTGGATGAAATCAAGAAGCGTGGGATCCGAGTT
GGCTACACCCCAGATGTCCTGACAGATACCACCGCCGAACTCGCAGTCTCCCTGCTACTT
ACCACCTGCCGCCGGTTGCCGGAGGCCATCGAGGAAGTGAAGAATGGTGGCTGGACCTCG
TGGAAGCCCCTCTGGCTGTGTGGCTATGGACTCACGCAGAGCACTGTCGGCATCATCGGG
CTGGGGCGCATAGGCCAGGCCATTGCTCGGCGTCTGAAACCATTCGGTGTCCAGAGATTT
CTGTACACAGGGCGCCAGCCCAGGCCTGAGGAAGCAGCAGAATTCCAGGCAGAGTTTGTG
TCTACCCCTGAGCTGGCTGCCCAATCTGATTTCATCGTCGTGGCCTGCTCCTTAACACCT
GCAACCGAGGGACTCTGCAACAAGGACTTCTTCCAGAAGATGAAGGAAACAGCTGTGTTC
ATCAACATCAGCAGGGGCGACGTCGTAAACCAGGACGACCTGTACCAGGCCTTGGCCAGT
GGTAAGATTGCAGCTGCTGGACTGGATGTGACGAGCCCAGAACCACTGCCTACAAACCAC
CCTCTCCTGACCCTGAAGAACTGTGTGATTCTGCCCCACATTGGCAGTGCCACCCACAGA
ACCCGCAACACCATGTCCTTGTTGGCAGCTAACAACTTGCTGGCTGGCCTGAGAGGGGAG
CCGATGCCTAGTGAACTCAAGCTGTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF134895

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_1_Locus:
9q12

# Metabolic_Enzyme_1_SNPs:
rs12002324; rs309458; rs309461; rs2768659; rs2736664; rs2768662; rs7867764; rs309455; rs309459; rs1887454; rs309453; rs2768658; rs12552734; rs309452; rs309460; rs309457; rs2235096; rs10973333; rs309456; rs309462; rs17885933; rs17411423; rs12683277; rs10973336; rs2768657; rs10973334; rs309454; rs4472607; rs7856656; rs4878690; rs7872991; rs10973329; rs7853540; rs7857159; rs10973327; rs10973328; rs7872720; rs6476631; rs7853526; rs11546642; rs35975284; rs11546644; rs1057507; rs3198078; rs2736669; rs2736662; rs2768660; rs2736670; rs35891798; rs2736673; rs34288288; rs41278295; rs41298174; rs2736665; rs2736660; rs2736667; rs10973335; rs2736671; rs2736661; rs41303225; rs16934118; rs2736663; rs1807410; rs35417895; rs2736666; rs2736674; rs10643023; rs2736668; rs34302950; rs11345501; rs2736672; rs309451; rs13299681; rs10973331; rs10679296; rs34280344; rs10973332; rs35292277; rs34688490; rs34632389; rs10643132; rs5897688; rs927929; rs34510989; rs10814535; rs10973324; rs10973338; rs10973339; rs10973340; rs11793053; rs12348205; rs13300415; rs17411255; rs17502738; rs1802995; rs2840246; rs309450; rs35680410; rs35720597; rs7022431; rs7031029; rs7038960; rs7039333

# Metabolic_Enzyme_1_General_References:
10524214; 10484776; 10679197

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6067

# Metabolic_Enzyme_2_Name:
Hydroxyacid oxidase 1

# Metabolic_Enzyme_2_Synonyms:
HAOX1; Glycolate oxidase; GOX

# Metabolic_Enzyme_2_Gene_Name:
HAO1

# Metabolic_Enzyme_2_Protein_Sequence:
>Hydroxyacid oxidase 1
MLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAET
DLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAE
AGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQ
LRMKNFETSTLSFSPEENFGDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILR
GDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDV
LKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLV
RKNPLAVSKI

# Metabolic_Enzyme_2_Number_of_Residues:
370

# Metabolic_Enzyme_2_Molecular_Weight:
40925

# Metabolic_Enzyme_2_Theoretical_pI:
8.29

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids

# Metabolic_Enzyme_2_Pathway:
map00630  Glyoxylate and dicarboxylate metabolism

# Metabolic_Enzyme_2_Reaction:
(S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01070:FMN_dh

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.3.15

# Metabolic_Enzyme_2_GenBank_ID_Protein:
7530485

# Metabolic_Enzyme_2_SwissProt_ID:
HAOX1_HUMAN (Q9UJM8)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
HAO1

# Metabolic_Enzyme_2_Geneatlas_id:
HAO1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:4809

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_2_Gene_Sequence:
>1113 bp
ATGCTCCCCCGGCTAATTTGTATCAATGATTATGAACAACATGCTAAATCAGTACTTCCA
AAGTCTATATATGACTATTACAGGTCTGGGGCAAATGATGAAGAAACTTTGGCTGATAAT
ATTGCAGCATTTTCCAGATGGAAGCTGTATCCAAGGATGCTCCGGAATGTTGCTGAAACA
GATCTGTCGACTTCTGTTTTAGGACAGAGGGTCAGCATGCCAATATGTGTGGGGGCTACG
GCCATGCAGCGCATGGCTCATGTGGACGGCGAGCTTGCCACTGTGAGAGCCTGTCAGTCC
CTGGGAACGGGCATGATGTTGAGTTCCTGGGCCACCTCCTCAATTGAAGAAGTGGCGGAA
GCTGGTCCTGAGGCACTTCGTTGGCTGCAACTGTATATCTACAAGGACCGAGAAGTCACC
AAGAAGCTAGTGCGGCAGGCAGAGAAGATGGGCTACAAGGCCATATTTGTGACAGTGGAC
ACACCTTACCTGGGCAACCGTCTGGATGATGTGCGTAACAGATTCAAACTGCCGCCACAA
CTCAGGATGAAAAATTTTGAAACCAGTACTTTATCATTTTCTCCTGAGGAAAATTTTGGA
GACGACAGTGGACTTGCTGCATATGTGGCTAAAGCAATAGACCCATCTATCAGCTGGGAA
GATATCAAATGGCTGAGAAGACTGACATCATTGCCAATTGTTGCAAAGGGCATTTTGAGA
GGTGATGATGCCAGGGAGGCTGTTAAACATGGCTTGAATGGGATCTTGGTGTCGAATCAT
GGGGCTCGACAACTCGATGGGGTGCCAGCCACTATTGATGTTCTGCCAGAAATTGTGGAG
GCTGTGGAAGGGAAGGTGGAAGTCTTCCTGGACGGGGGTGTGCGGAAAGGCACTGATGTT
CTGAAAGCTCTGGCTCTTGGCGCCAAGGCTGTGTTTGTGGGGAGACCAATCGTTTGGGGC
TTAGCTTTCCAGGGGGAGAAAGGTGTTCAAGATGTCCTCGAGATACTAAAGGAAGAATTC
CGGTTGGCCATGGCTCTGAGTGGGTGCCAGAATGTGAAAGTCATCGACAAGACATTGGTG
AGGAAAAATCCTTTGGCCGTTTCCAAGATCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF244134

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_2_Locus:
20p12

# Metabolic_Enzyme_2_SNPs:
rs33931524; rs3747926; rs2243433; rs1569454; rs2017494; rs2423325; rs1883209; rs2235241; rs941425; rs2294301; rs2142696; rs2250943; rs2247586; rs2142697; rs2294300; rs2423336; rs1540901; rs2423326; rs6086284; rs2235237; rs6055364; rs1883210; rs2423334; rs2235243; rs6108081; rs8119321; rs941426; rs8113842; rs6133511; rs7260781; rs2235250; rs2254923; rs6055372; rs2255183; rs2254801; rs2294304; rs2235240; rs12625899; rs6117980; rs6055390; rs7266916; rs2423322; rs2327003; rs6516330; rs6055375; rs6055400; rs1883211; rs12710332; rs6055391; rs6055398; rs1028310; rs2423335; rs2247663; rs1983560; rs12625217; rs2250429; rs2205817; rs2423324; rs6108080; rs4140559; rs2294306; rs1569453; rs6118004; rs2247673; rs2423330; rs2142700; rs16994127; rs6086276; rs2223276; rs1983559; rs6038976; rs12625244; rs8119185; rs7266518; rs2294298; rs2235242; rs2423328; rs6086287; rs6086282; rs2235245; rs6077285; rs11907636; rs3930510; rs2423327; rs6086279; rs2235244; rs7266199; rs2205818; rs11905753; rs2294299; rs6055370; rs6140463; rs8118176; rs2142701; rs7269011; rs6055367; rs6117978; rs16994181; rs12479800; rs17332292; rs7271299; rs8119175; rs6055378; rs2235248; rs8124232; rs2205821; rs2423331; rs6117982; rs6038977; rs2235247; rs11907197; rs2142698; rs3938382; rs2250928; rs6055396; rs17423211; rs6055366; rs2423333; rs2247585; rs2235246; rs11698761; rs13038486; rs2235238; rs16994134; rs6133515; rs2223275; rs13040468; rs6108079; rs8114834; rs6140461; rs7361466; rs2235239; rs13041645; rs6055387; rs2294307; rs2294305; rs2223274; rs2281026; rs4140560; rs2250567; rs6086290; rs6140468; rs12624817; rs9753568; rs6133516; rs6140469; rs6055363; rs6140467; rs16994212; rs12625575; rs6055362; rs17424349; rs6117976; rs12624982; rs34249643; rs6118003; rs6038973; rs6140460; rs2294302; rs35708943; rs35500410; rs3215458; rs3830727; rs6140455; rs2272813; rs34475991; rs33971182; rs6038975; rs6117993; rs10610494; rs6140458; rs11475177; rs34245391; rs11469680; rs7345525; rs3817774; rs6118010; rs35108815; rs35848853; rs6055395; rs2423329; rs5840240; rs6117987; rs6055399; rs35930462; rs6086277; rs10693627; rs35338069; rs11468202; rs34416691; rs34473022; rs6055371; rs11475130; rs11329950; rs10630953; rs6140464; rs6086272; rs13045772; rs34671595; rs6117997; rs11473859; rs6055392; rs10585629; rs35105944; rs36037568; rs6118000; rs11467510; rs11479131; rs35974266; rs11468404; rs11438122; rs8122709; rs6108076; rs2294303; rs3215459; rs11478854; rs6118009; rs7267272; rs6117985; rs2205816; rs11476410; rs11483714; rs11484347; rs28546842; rs6140459; rs6055377; rs6086274; rs34236287; rs28599710; rs35669859; rs6055379; rs6118014; rs34880394; rs34334468; rs6117990; rs6147282; rs11477740; rs2205820; rs6118013; rs6140465; rs6117998; rs6086268; rs6077291; rs3215460; rs34412020; rs6117983; rs6086280; rs7266585; rs10590340; rs13039013; rs35798481; rs6117988; rs6086271; rs34625451; rs6038979; rs11697565; rs6055374; rs6077290; rs6117999; rs6055393; rs6086269; rs35385638; rs33934623; rs35526555; rs2142699; rs6117984; rs34344737; rs35478783; rs6108077; rs34672598; rs11480593; rs2205819; rs16994117; rs35960606; rs6140466; rs13045696; rs35264555; rs11470783; rs3215457; rs6117991; rs6055373; rs6055369; rs6118002; rs5840241; rs6086270; rs11476936; rs35845521; rs10543894; rs6118012; rs6140457; rs28396241; rs34395726; rs11470902; rs11477909; rs11468259; rs35502451; rs3215461; rs7263368; rs4816026; rs6055384; rs6117989; rs11480990; rs11699240; rs6118001; rs34357188; rs34819349; rs6055397; rs6055394; rs6077286; rs6118007; rs6140462; rs6055365; rs11358812; rs7268911; rs7269597; rs11478920; rs6117995; rs6117992; rs6108078; rs7347181; rs11481371; rs8123185; rs2423332; rs34931508; rs6086278; rs35167351; rs34198710; rs6055388; rs6055368; rs6117981; rs6117986; rs2235249; rs11475213; rs35267240; rs34439496; rs8182639; rs34738743; rs34048209; rs6086267; rs6055361; rs6038972; rs7270706; rs11699153; rs6086266; rs35365849; rs2142702; rs4366971; rs6038970; rs6038971; rs6055351; rs6055354; rs6055357; rs6055359; rs6055360; rs6055404; rs6055405; rs6055406; rs6055408; rs6055409; rs6077284; rs6077294; rs6086261; rs6086262; rs6086263; rs6086265; rs6086291; rs6108074; rs6108075; rs6117974; rs6118015; rs6118017; rs6118025; rs6133508; rs6133517; rs6140450; rs6140452; rs6140453; rs7343234; rs8120370; rs8120893

# Metabolic_Enzyme_2_General_References:
10978532; 10777549; 11780052

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6068

# Metabolic_Enzyme_3_Name:
Hydroxyacid oxidase 2

# Metabolic_Enzyme_3_Synonyms:
HAOX2; (S-2-hydroxy-acid oxidase, peroxisomal; Long chain alpha-hydroxy acid oxidase; Long- chain L-2-hydroxy acid oxidase

# Metabolic_Enzyme_3_Gene_Name:
HAO2

# Metabolic_Enzyme_3_Protein_Sequence:
>Hydroxyacid oxidase 2
MSLVCLTDFQAHAREQLSKSTRDFIEGGADDSITRDDNIAAFKRIRLRPRYLRDVSEVDT
RTTIQGEEISAPICIAPTGFHCLVWPDGEMSTARAAQAAGICYITSTFASCSLEDIVIAA
PEGLRWFQLYVHPDLQLNKQLIQRVESLGFKALVITLDTPVCGNRRHDIRNQLRRNLTLT
DLQSPKKGNAIPYFQMTPISTSLCWNDLSWFQSITRLPIILKGILTKEDAELAVKHNVQG
IIVSNHGGRQLDEVLASIDALTEVVAAVKGKIEVYLDGGVRTGNDVLKALALGAKCIFLG
RPILWGLACKGEHGVKEVLNILTNEFHTSMALTGCRSVAEINRNLVQFSRL

# Metabolic_Enzyme_3_Number_of_Residues:
351

# Metabolic_Enzyme_3_Molecular_Weight:
38839

# Metabolic_Enzyme_3_Theoretical_pI:
7.69

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids

# Metabolic_Enzyme_3_Pathway:
map00630  Glyoxylate and dicarboxylate metabolism

# Metabolic_Enzyme_3_Reaction:
(S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01070:FMN_dh

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.1.3.15

# Metabolic_Enzyme_3_GenBank_ID_Protein:
7208438

# Metabolic_Enzyme_3_SwissProt_ID:
HAOX2_HUMAN (Q9NYQ3)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
HAO2

# Metabolic_Enzyme_3_Geneatlas_id:
HAO2

# Metabolic_Enzyme_3_hgnc_id:
HGNC:4810

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_3_Gene_Sequence:
>1056 bp
ATGTCCTTGGTGTGTTTGACAGACTTTCAGGCCCATGCGCGAGAGCAGCTGTCTAAGTCA
ACTCGGGATTTTATTGAAGGTGGAGCAGATGACAGCATCACGCGGGATGACAACATTGCA
GCATTTAAAAGAATTCGCCTCCGTCCGCGGTACCTGAGAGATGTGTCTGAGGTGGACACC
AGAACCACAATCCAAGGGGAGGAGATCAGTGCCCCTATTTGTATCGCACCCACAGGGTTC
CACTGCCTTGTCTGGCCTGATGGGGAAATGAGCACAGCAAGAGCTGCCCAAGCGGCTGGT
ATCTGCTACATCACCAGCACATTTGCCAGCTGTAGCCTTGAAGACATTGTCATTGCAGCT
CCCGAAGGCCTCCGATGGTTCCAACTCTATGTGCATCCAGACCTGCAGCTGAACAAACAG
TTGATCCAGAGGGTAGAATCCCTAGGTTTCAAAGCTTTGGTAATAACTTTGGATACACCT
GTATGTGGCAACAGGCGACATGACATTCGAAACCAGTTGAGGAGGAACTTAACACTAACA
GATCTTCAATCACCTAAAAAGGGAAATGCAATACCTTATTTCCAGATGACTCCTATCAGC
ACTTCTCTCTGCTGGAATGATCTCTCCTGGTTTCAGAGCATAACTCGATTGCCCATCATC
CTGAAAGGGATTTTGACAAAAGAGGATGCAGAGTTAGCTGTGAAGCACAATGTCCAGGGT
ATCATTGTTTCCAACCATGGTGGGAGGCAGCTTGATGAGGTTCTTGCTTCAATTGATGCT
TTGACAGAAGTGGTGGCTGCTGTAAAGGGGAAAATTGAAGTCTACCTGGATGGCGGGGTC
CGAACTGGCAATGATGTGCTGAAGGCTCTGGCCCTTGGAGCTAAGTGCATTTTTCTTGGG
AGACCAATCCTATGGGGCCTTGCCTGCAAGGGTGAACATGGTGTTAAGGAAGTTTTGAAC
ATTTTAACAAATGAGTTCCACACTTCCATGGCCCTTACAGGCTGCCGGTCGGTCGCTGAG
ATCAATCGAAACTTGGTCCAGTTTTCCAGGCTGTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
AF231917

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_3_Locus:
1p13.3-p13.1

# Metabolic_Enzyme_3_SNPs:
rs34638261; rs2275607; rs35295280; rs2224995; rs3765953; rs3765955; rs3765951; rs3765956; rs10923804; rs7514283; rs6667104; rs3765952; rs10494225; rs6694847; rs6667203; rs10923802; rs6691943; rs7513419; rs12071883; rs6704362; rs7529983; rs3753260; rs4659003; rs3765954; rs3765957; rs10802090; rs17023507; rs17013697; rs1341007; rs2298028; rs6670497; rs6667679; rs2275608; rs1417604; rs7552690; rs2298027; rs12032036; rs6663287; rs3765949; rs3207643; rs6428816; rs10923805; rs7528838; rs2182243; rs17023517; rs3765950; rs11586988; rs9728422; rs10802092; rs6675731; rs3753263; rs3753264; rs3753262; rs6656360; rs3753261; rs12402209; rs6661625; rs41313995; rs41306185; rs4659002; rs11398278; rs12753975; rs12118920; rs12743964; rs34875589; rs12724529; rs7547008; rs36096589; rs35468112; rs35672626; rs35324941; rs35351478; rs12404377; rs35476629; rs3753259; rs4659004; rs11582039; rs10585699; rs11366732; rs41313280; rs6678290; rs34306563; rs28570107; rs41443445; rs3753265; rs3834006; rs3818927; rs3820031; rs10923808; rs12047811; rs12404344; rs12740687; rs1325751; rs1536228; rs17023479; rs1935248; rs2005390; rs2885607; rs35298838; rs3753266; rs3820032; rs6658331; rs6683756; rs879333; rs879334; rs942903; rs947127

# Metabolic_Enzyme_3_General_References:
10777549

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5504

# Metabolic_Enzyme_4_Name:
Catechol O-methyltransferase

# Metabolic_Enzyme_4_Synonyms:
Not Available

# Metabolic_Enzyme_4_Gene_Name:
COMT

# Metabolic_Enzyme_4_Protein_Sequence:
>Catechol Omethyltransferase
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRIL
NHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCG
YSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKY
DVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFE
CTHYQSFLEYREVVDGLEKAIYKGPGSEAGP

# Metabolic_Enzyme_4_Number_of_Residues:
271

# Metabolic_Enzyme_4_Molecular_Weight:
30037

# Metabolic_Enzyme_4_Theoretical_pI:
5.15

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  O-methyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol

# Metabolic_Enzyme_4_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_4_Reaction:
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01596:Methyltransf_3

# Metabolic_Enzyme_4_Signals:
1-32

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.1.1.6

# Metabolic_Enzyme_4_GenBank_ID_Protein:
180920

# Metabolic_Enzyme_4_SwissProt_ID:
COMT_HUMAN (P21964)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
COMT

# Metabolic_Enzyme_4_Geneatlas_id:
COMT

# Metabolic_Enzyme_4_hgnc_id:
HGNC:2228

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Isoform S-COMT:Cytoplasm. Isoform MB-COMT:Cell membrane; single-pass type II membrane protein; extracellular side

# Metabolic_Enzyme_4_Gene_Sequence:
>816 bp
ATGCCGGAGGCCCCGCCTCTGCTGTTGGCAGCTGTGTTGCTGGGCCTGGTGCTGCTGGTG
GTGCTGCTGCTGCTTCTGAGGCACTGGGGCTGGGGCCTGTGCCTTATCGGCTGGAACGAG
TTCATCCTGCAGCCCATCCACAACCTGCTCATGGGTGACACCAAGGAGCAGCGCATCCTG
AACCACGTGCTGCAGCATGCGGAGCCCGGGAACGCACAGAGCGTGCTGGAGGCCATTGAC
ACCTACTGCGAGCAGAAGGAGTGGGCCATGAACGTGGGCGACAAGAAAGGCAAGATCGTG
GACGCCGTGATTCAGGAGCACCAGCCCTCCGTGCTGCTGGAGCTGGGGGCCTACTGTGGC
TACTCAGCTGTGCGCATGGCCCGCCTGCTGTCACCAGGGGCGAGGCTCATCACCATCGAG
ATCAACCCCGACTGTGCCGCCATCACCCAGCGGATGGTGGATTTCGCTGGCGTGAAGGAC
AAGGTCACCCTTGTGGTTGGAGCGTCCCAGGACATCATCCCCCAGCTGAAGAAGAAGTAT
GATGTGGACACACTGGACATGGTCTTCCTCGACCACTGGAAGGACCGGTACCTGCCGGAC
ACGCTTCTCTTGGAGGAATGTGGCCTGCTGCGGAAGGGGACAGTGCTACTGGCTGACAAC
GTGATCTGCCCAGGTGCGCCAGACTTCCTAGCACACGTGCGCGGGAGCAGCTGCTTTGAG
TGCACACACTACCAATCGTTCCTGGAATACAGGGAGGTGGTGGACGGCCTGGAGAAGGCC
ATCTACAAGGGCCCAGGCAGCGAAGCAGGGCCCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M65212

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_4_Locus:
22q11.21-q11.23|22q11.21

# Metabolic_Enzyme_4_SNPs:
rs5031015; rs6267; rs4680; rs13306279; rs13306281; rs6270; rs740602; rs8192488; rs4818; rs769223; rs769224; rs165631; rs4633; rs6269; rs739368; rs165656; rs4646312; rs5992501; rs7287550; rs165722; rs5746849; rs11569715; rs740603; rs9332380; rs7290221; rs174674; rs9332351; rs3810595; rs174675; rs5993887; rs9332361; rs6518593; rs174680; rs9332356; rs5993882; rs11569716; rs3087869; rs9332325; rs174673; rs174678; rs5993883; rs933271; rs9332359; rs165767; rs9332347; rs8185002; rs5993879; rs9332363; rs174691; rs9332332; rs5992500; rs174682; rs9332346; rs13306280; rs362204; rs174688; rs9332342; rs11569717; rs174695; rs5993881; rs7291003; rs1544325; rs9332331; rs3819621; rs174684; rs34798238; rs174677; rs174690; rs9606196; rs174693; rs11912353; rs12053782; rs11913025; rs36111598; rs5993888; rs9332362; rs174685; rs34438295; rs5992499; rs34691071; rs9332357; rs174692; rs9332334; rs3838146; rs9332333; rs9332352; rs35014456; rs35527466; rs35558779; rs11704299; rs9332350; rs6268; rs34450201; rs9680656; rs1055503; rs11912354; rs11089323; rs5993884; rs16982842; rs174679; rs9332353; rs34300220; rs9332358; rs9332360; rs34937293; rs34966851; rs174676; rs16982844; rs5844402; rs9332323; rs35919169; rs174683; rs35777291; rs9332348; rs8140865; rs34686565; rs165737; rs4646315; rs2239393; rs165774; rs9306235; rs740601; rs5993889; rs9306234; rs4646316; rs8140835; rs4646317; rs9332370; rs174697; rs174696; rs9332377; rs4646318; rs1109436; rs9332368; rs3218737; rs34068292; rs9332369; rs9332364; rs9332372; rs9332367; rs9332365; rs4646313; rs34446512; rs34819182; rs174699; rs34234839; rs165895; rs165599; rs9332381; rs35478083; rs36082074; rs11544670; rs4986871; rs11544669; rs165879; rs35791904; rs35788262; rs13054814; rs5992498; rs5748490; rs361698; rs28600912; rs9605040; rs11703339; rs9332319; rs174689; rs9606193; rs5844403; rs9332340; rs34778315; rs11703340; rs5993886; rs14968; rs9332344; rs28621910; rs3081743; rs174681; rs361549; rs35280052; rs361708; rs12167365; rs2004497; rs12170804; rs35357972; rs9332321; rs361574; rs9332328; rs35920235; rs9332337; rs5993880; rs12814; rs9332343; rs11544667; rs9606195; rs9332349; rs11296030; rs5748492; rs9332354; rs34029447; rs35188675; rs3819619; rs8136901; rs35094299; rs9332322; rs28804429; rs174687; rs9332339; rs11912495; rs35617967; rs9332327; rs9332336; rs3841769; rs12167215; rs362253; rs9332338; rs35689277; rs11703069; rs174686; rs12168881; rs9606194; rs361699; rs9332355; rs3081741; rs5746850; rs9617852; rs28565095; rs13306277; rs174698; rs9332373; rs9332374; rs9332366; rs13054356; rs35819339; rs11460758; rs4646314; rs34016976; rs2904564; rs12158230; rs13055002; rs9332375; rs28562050; rs9332378; rs9332371; rs9332376; rs10427781; rs10427983; rs10483103; rs1110477; rs1110478; rs1110479; rs12165997; rs12169508; rs12627876; rs165655; rs165728; rs165815; rs165824; rs165840; rs165849; rs1800749; rs2020917; rs2073749; rs2239394; rs2239395; rs2240713; rs2240714; rs2240715; rs2240718; rs2518823; rs2518824; rs2871047; rs34134422; rs35219372; rs3788319; rs3788320; rs4646310; rs5746846; rs5746847; rs5748483; rs5748484; rs5993890; rs5993891; rs7288060; rs737864; rs737865; rs737866; rs758373; rs8140265; rs887199; rs887200; rs9265; rs9332314; rs9332315; rs9605030; rs9605031; rs9606186; rs9606189; rs9606201; rs9618716

# Metabolic_Enzyme_4_General_References:
1707278; 1847521; 8055944; 1993083; 1765063; 8807664; 10391209

# Metabolic_Enzyme_4_References:
12741370

# Metabolic_Enzyme_5_ID:
5393

# Metabolic_Enzyme_5_Name:
Amine oxidase [flavin-containing] B

# Metabolic_Enzyme_5_Synonyms:
Monoamine oxidase type B; MAO-B

# Metabolic_Enzyme_5_Gene_Name:
MAOB

# Metabolic_Enzyme_5_Protein_Sequence:
>Amine oxidase flavincontaining 
BMSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGS
YVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFW
RTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHE
VSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYID
QTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIV
YYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEE
RLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVD
RIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITT
TFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV

# Metabolic_Enzyme_5_Number_of_Residues:
520

# Metabolic_Enzyme_5_Molecular_Weight:
58764

# Metabolic_Enzyme_5_Theoretical_pI:
7.55

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine

# Metabolic_Enzyme_5_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_5_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01593:Amino_oxidase

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
490-516

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.4.3.4

# Metabolic_Enzyme_5_GenBank_ID_Protein:
398415

# Metabolic_Enzyme_5_SwissProt_ID:
AOFB_HUMAN (P27338)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
MAOB

# Metabolic_Enzyme_5_Geneatlas_id:
MAOB

# Metabolic_Enzyme_5_hgnc_id:
HGNC:6834

# Metabolic_Enzyme_5_PDB_ID:
2BK3

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type IV membrane protein; cytoplasmic side

# Metabolic_Enzyme_5_Gene_Sequence:
>1560 bp
ATGAGCAACAAATGCGACGTGGTCGTGGTGGGGGGCGGCATCTCAGGTATGGCAGCAGCC
AAACTTCTGCATGACTCTGGACTGAATGTGGTTGTTCTGGAAGCCCGGGACCGTGTGGGA
GGCAGGACTTACACTCTTAGGAACCAAAAGGTTAAATATGTGGACCTTGGAGGATCCTAT
GTTGGACCAACCCAGAATCGTATCTTGAGATTAGCCAAGGAGCTAGGATTGGAGACCTAC
AAAGTGAATGAGGTTGAGCGTCTGATCCACCATGTAAAGGGCAAATCATACCCCTTCAGG
GGGCCATTCCCACCTGTATGGAATCCAATTACCTACTTAGATCATAACAACTTTTGGAGG
ACAATGGATGACATGGGGCGAGAGATTCCGAGTGATGCCCCATGGAAGGCTCCCCTTGCA
GAAGAGTGGGACAACATGACAATGAAGGAGCTACTGGACAAGCTCTGCTGGACTGAATCT
GCAAAGCAGCTTGCCACTCTCTTTGTGAACCTGTGTGTCACTGCAGAGACCCATGAGGTC
TCTGCTCTCTGGTTCCTGTGGTATGTGAAGCAGTGTGGAGGCACAACAAGAATCATCTCG
ACAACAAATGGAGGACAGGAGAGGAAATTTGTGGGCGGATCTGGTCAAGTGAGTGAGCGG
ATAATGGACCTCCTTGGAGACCGAGTGAAGCTGGAGAGGCCTGTGATCTACATTGACCAG
ACAAGAGAAAATGTCCTTGTGGAGACCCTAAACCATGAGATGTATGAGGCTAAATATGTG
ATTAGTGCTATTCCTCCTACTCTGGGCATGAAGATTCACTTCAATCCCCCTCTGCCAATG
ATGAGAAACCAGATGATCACTCGTGTGCCTTTGGGTTCAGTCATCAAGTGTATAGTTTAT
TATAAAGAGCCTTTCTGGAGGAAAAAGGATTACTGTGGAACCATGATTATTGATGGAGAA
GAAGCTCCAGTTGCCTACACGTTGGATGATACCAAACCTGAAGGCAACTATGCTGCCATA
ATGGGATTTATCCTGGCCCACAAAGCCAGAAAACTGGCACGTCTTACCAAAGAGGAAAGG
TTGAAGAAACTTTGTGAACTCTATGCCAAGGTTCTGGGTTCCCTAGAAGCTCTGGAGCCA
GTGCATTATGAAGAAAAGAACTGGTGTGAGGAGCAGTACTCTGGGGGCTGCTACACAACT
TATTTCCCCCCTGGGATCCTGACTCAATATGGAAGGGTTCTACGCCAGCCAGTGGACAGG
ATTTACTTTGCAGGCACCGAGACTGCCACACACTGGAGCGGCTACATGGAGGGGGCTGTA
GAGGCCGGGGAGAGAGCAGCCCGAGAGATCCTGCATGCCATGGGGAAGATTCCAGAGGAT
GAAATCTGGCAGTCAGAACCAGAGTCTGTGGATGTCCCTGCACAGCCCATCACCACCACC
TTTTTGGAGAGACATTTGCCCTCCGTGCCAGGCCTGCTCAGGCTGATTGGATTGACCACC
ATCTTTTCAGCAACGGCTCTTGGCTTCCTGGCCCACAAAAGGGGGCTACTTGTGAGAGTC


# Metabolic_Enzyme_5_GenBank_ID_Gene:
S62734

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_5_Locus:
Xp11.23

# Metabolic_Enzyme_5_SNPs:
rs7879356; rs6324; rs12010260; rs2072745; rs17462; rs3027440; rs7066677; rs3027439; rs1799836; rs3027453; rs2311013; rs3027441; rs5905512; rs3027459; rs2239450; rs2239441; rs7890174; rs5952297; rs3027444; rs5952330; rs7883073; rs5952671; rs6520902; rs2239449; rs6651806; rs3027454; rs7057075; rs12394221; rs2238969; rs12008119; rs7888450; rs12388038; rs2283727; rs12013965; rs17310637; rs12008438; rs5952294; rs5952340; rs12008548; rs12014398; rs1014876; rs3027449; rs2283730; rs2283729; rs5952813; rs6520901; rs5952352; rs2205655; rs10521432; rs6610856; rs12006628; rs3027450; rs6610853; rs2283731; rs3027456; rs2283728; rs9887326; rs5952325; rs3027442; rs7879586; rs12389168; rs3817729; rs12851487; rs5952686; rs3736672; rs2056913; rs1569424; rs7053203; rs2092042; rs7876594; rs12010996; rs3027457; rs9887047; rs3027451; rs17146716; rs7061798; rs3027464; rs6609259; rs3027446; rs736944; rs2239442; rs6609260; rs7067187; rs3027466; rs12558324; rs7888462; rs3027452; rs2092040; rs4824562; rs17146721; rs7884044; rs3027461; rs12389234; rs12007768; rs17244906; rs5952795; rs17146719; rs5905449; rs5952799; rs12394863; rs3027458; rs3027443; rs9698576; rs2092041; rs7892217; rs7061088; rs12689868; rs7067027; rs3027448; rs12558614; rs7057957; rs1040398; rs1040400; rs3027435; rs1181252; rs1040399; rs3027434; rs17852046; rs12850496; rs12845773; rs17856663; rs12845783; rs5952696; rs3191382; rs1181251; rs35285191; rs1051000; rs1803940; rs3027438; rs1051003; rs1050990; rs4339787; rs28530533; rs3027468; rs5952754; rs5952690; rs12558961; rs12852985; rs34468176; rs2311012; rs5905428; rs34165496; rs34825602; rs7892394; rs5952812; rs11091124; rs5906017; rs28522648; rs5952677; rs11282093; rs5906045; rs3838196; rs3027455; rs28667959; rs3027463; rs35676271; rs12841775; rs35574902; rs3027447; rs28657720; rs6610848; rs28531879; rs4824563; rs6610854; rs7060566; rs12396954; rs3027469; rs35687186; rs5952736; rs35375952; rs7057164; rs34716997; rs7062993; rs7063171; rs11412800; rs6651629; rs12845848; rs12853563; rs12012179; rs28368734; rs12115950; rs35968321; rs3027460; rs12394356; rs35439218; rs36085366; rs34265248; rs35762562; rs2239451; rs34292051; rs3027445; rs11320541; rs10481834; rs12845568; rs4592179; rs3216388; rs34945383; rs34220802; rs6610855; rs34261731; rs28485908; rs7888867; rs11431011; rs4071606; rs12390352; rs10567219; rs35520175; rs28527225; rs36068670; rs5952687; rs7888857; rs5952777; rs34822523; rs12010683; rs7883563; rs5952814; rs36209687; rs5952751; rs2238970; rs5952744; rs35797631; rs12389578; rs7474005; rs3027465; rs5952768; rs5906031; rs28636832; rs34252524; rs7058426; rs12391346; rs12689072; rs35943983; rs12395246; rs11414517; rs3027467; rs12013925; rs3736671; rs28421767; rs7058949; rs35634965; rs28754429; rs1894610; rs36102775; rs9887081; rs5952817; rs12855578; rs10658111; rs7062575; rs4620438; rs28568938; rs35291347; rs11797733; rs35054600; rs5952335; rs3027462; rs5952712; rs34752122; rs3054011; rs3027437; rs28577261; rs3027433; rs3761584; rs3027436; rs3027432; rs12558036; rs3027418; rs3027419; rs3027420; rs3027421; rs3027423; rs3027424; rs3027425; rs3027426; rs3027427; rs3027428; rs3027429; rs3027430; rs3027431; rs4351544; rs7884135; rs7890899

# Metabolic_Enzyme_5_General_References:
2023912; 3387449; 8515265; 1432104; 11049757; 11753429

# Metabolic_Enzyme_5_References:
11871228; 16144652

# Macromolecular_Interacting_Partner_1_ID:
7735

# Macromolecular_Interacting_Partner_1_Name:
Methyl-CpG-binding domain protein 2

# Macromolecular_Interacting_Partner_1_Synonyms:
Methyl-CpG-binding protein MBD2; Demethylase; DMTase

# Macromolecular_Interacting_Partner_1_Gene_Name:
MBD2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>MethylCpGbinding domain protein 2
MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRG
RGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGG
APRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYF
SPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLN
TTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQII
KTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCK
AFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
411

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
43255

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
10.76

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemi-methylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Isoform 1 may enhance the activation of some unmethylated cAMP-responsive promoters. Reports about DNA demethylase activity of isoform 2 are contradictory

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01429:MBD

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
3800793

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
MBD2_HUMAN (Q9UBB5)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
MBD2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
MBD2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6917

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Nucleus. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1236 bp
ATGCGCGCGCACCCGGGGGGAGGCCGCTGCTGCCCGGAGCAGGAGGAGGGGGAGAGTGCG
GCGGGCGGCAGCGGCGCTGGCGGCGACTCCGCCATAGAGCAGGGGGGCCAGGGCAGCGCG
CTCGCCCCGTCCCCGGTGAGCGGCGTGCGCAGGGAAGGCGCTCGGGGCGGCGGCCGTGGC
CGGGGGCGGTGGAAGCAGGCGGGCCGGGGCGGCGGCGTCTGTGGCCGTGGCCGGGGCCGG
GGCCGTGGCCGGGGACGGGGACGGGGCCGGGGCCGGGGCCGCGGCCGTCCCCCGAGTGGC
GGCAGCGGCCTTGGCGGCGACGGCGGCGGCTGCGGCGGCGGCGGCAGCGGTGGCGGCGGC
GCCCCCCGGCGGGAGCCGGTCCCTTTCCCGTCGGGGAGCGCGGGGCCGGGGCCCAGGGGA
CCCCGGGCCACGGAGAGCGGGAAGAGGATGGATTGCCCGGCCCTCCCCCCCGGATGGAAG
AAGGAGGAAGTGATCCGAAAATCTGGGCTAAGTGCTGGCAAGAGCGATGTCTACTACTTC
AGTCCAAGTGGTAAGAAGTTCAGAAGCAAGCCTCAGTTGGCAAGGTACCTGGGAAATACT
GTTGATCTCAGCAGTTTTGACTTCAGAACTGGAAAGATGATGCCTAGTAAATTACAGAAG
AACAAACAGAGACTGCGAAACGATCCTCTCAATCAAAATAAGGGTAAACCAGACTTGAAT
ACAACATTGCCAATTAGACAAACAGCATCAATTTTCAAACAACCGGTAACCAAAGTCACA
AATCATCCTAGTAATAAAGTGAAATCAGACCCACAACGAATGAATGAACAGCCACGTCAG
CTTTTCTGGGAGAAGAGGCTACAAGGACTTAGTGCATCAGATGTAACAGAACAAATTATA
AAAACCATGGAACTACCCAAAGGTCTTCAAGGAGTTGGTCCAGGTAGCAATGATGAGACC
CTTTTATCTGCTGTTGCCAGTGCTTTGCACACAAGCTCTGCGCCAATCACAGGGCAAGTC
TCCGCTGCTGTGGAAAAGAACCCTGCTGTTTGGCTTAACACATCTCAACCCCTCTGCAAA
GCTTTTATTGTCACAGATGAAGACATCAGGAAACAGGAAGAGCGAGTACAGCAAGTACGC
AAGAAATTGGAAGAAGCACTGATGGCAGACATCTTGTCGCGAGCTGCTGATACAGAAGAG
ATGGATATTGAAATGGACAGTGGAGATGAAGCCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AF072242

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:18

# Macromolecular_Interacting_Partner_1_Locus:
18q21

# Macromolecular_Interacting_Partner_1_SNPs:
rs1259938; rs1259941; rs7614; rs3786254; rs4041245; rs1730267; rs11877833; rs3786255; rs35733000; rs4987184; rs1259940; rs11663319; rs1259939; rs1145308; rs661215; rs676800; rs1145316; rs543241; rs2926997; rs585835; rs584330; rs475368; rs2926341; rs8083077; rs4940316; rs687994; rs599482; rs8090480; rs573285; rs672947; rs1145315; rs8094493; rs1145309; rs4041246; rs140691; rs609791; rs1790514; rs492726; rs693857; rs1145317; rs685057; rs8086950; rs662336; rs572797; rs10502986; rs1145310; rs7234495; rs4939750; rs8094185; rs479852; rs9958418; rs7232422; rs7241063; rs9960390; rs1145311; rs570017; rs570867; rs12957175; rs615696; rs1145312; rs16957946; rs8089935; rs7237892; rs10502987; rs3017292; rs1730270; rs4940315; rs16957921; rs1267799; rs4939751; rs9963926; rs498705; rs656923; rs8097780; rs583268; rs4987185; rs629824; rs17554142; rs16957953; rs7238796; rs4940312; rs629473; rs17462973; rs4987186; rs671835; rs656306; rs642361; rs35040517; rs16957939; rs9951912; rs11873149; rs9807692; rs1259858; rs17462765; rs17462646; rs16957932; rs603097; rs12608387; rs35915489; rs9963869; rs753864; rs7241067; rs1268764; rs11875248; rs1145307; rs11345394; rs11344752; rs9946304; rs34174132; rs11364876; rs28404719; rs9956656; rs11552898; rs1790513; rs10558467; rs3017295; rs3017287; rs623876; rs634693; rs9961259; rs642383; rs34993600; rs1145313; rs678114; rs8093652; rs7229672; rs34025949; rs16957923; rs8092125; rs1730279; rs35601988; rs35170749; rs16957906; rs35186700; rs1730271; rs1790515; rs12326535; rs34382203; rs1675718; rs35225687; rs509794; rs34458441; rs5825061; rs28448589; rs3018200; rs11874884; rs645506; rs35237708; rs34234339; rs34545409; rs36037876; rs36079641; rs626357; rs34556367; rs2169361; rs16957902; rs8094268; rs36230166; rs510530; rs34887478; rs3017286; rs12963699; rs11277762; rs35790077; rs10607975; rs35199872; rs12232598; rs543989; rs16957887; rs594296; rs611912; rs2926999; rs2199388; rs11300205; rs7235939; rs2926343; rs645961; rs7233296; rs16957881; rs11293678; rs35824179; rs35056647; rs2956143; rs554633; rs681289; rs2926342; rs10719481; rs3017296; rs11285730; rs35643173; rs34165824; rs8095425; rs35571665; rs16957892; rs34076609; rs10607976; rs1812558; rs1674711; rs35362298; rs7239431; rs34992594; rs28433825; rs7240184; rs36115254; rs35922006; rs3017288; rs34003182; rs1145314; rs1730269; rs17463119; rs586244; rs34014406; rs35697526; rs10666436; rs2614359; rs668141; rs34283776; rs35667017; rs3018197; rs12963932; rs34366283; rs3017294; rs613506; rs11295866; rs684456; rs34113185; rs2446537; rs1272783; rs681942; rs12326943; rs34411987; rs34574073; rs1145319; rs11271806; rs2219626; rs35551191; rs586302; rs28637773; rs36211882; rs7241787; rs2610528; rs2610529; rs568092; rs2056778; rs35696367; rs473734; rs4939752; rs34716232; rs9748585; rs11665560; rs5825062; rs12608372; rs3017298; rs28448407; rs4940317; rs35153750; rs11875214; rs1259842; rs1259936; rs1259937; rs12607263; rs1273266; rs1471216; rs16957870; rs636450; rs649780; rs649896; rs8084184; rs8086877; rs8089348; rs9807513

# Macromolecular_Interacting_Partner_1_General_References:
9774669; 10441743; 10947852; 11102443; 12183469

# Macromolecular_Interacting_Partner_1_References:
10591845; 10671462; 11092855; 14532071

End of HMDB00118

Beginning of HMDB00119
# Accession_No:
HMDB00119

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-07-20 02:53:46

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Glyoxylic acid

# Description:
Glyoxylic acid or oxoacetic acid is an organic compound that is both an aldehyde and a carboxylic acid.  Glyoxylic acid is a liquid with a melting Point of -93 degree centigrade and a boiling Point of 111 degree centigrade.  It is an intermediate of the glyoxylate cycle, which enables certain organisms to convert fatty acids into carbohydrates.

# Synonyms:
Formylformate; Formylformic acid; Glyoxalate; Glyoxalic acid; Glyoxylate; Glyoxylic acid; Oxalaldehydate; Oxalaldehydic acid; Oxoacetate; Oxoacetic acid; Oxoethanoate; Oxoethanoic acid; a-Ketoacetate; a-Ketoacetic acid; alpha-Ketoacetate; alpha-Ketoacetic acid

# Chemical_IUPAC_Name:
Acetic acid, oxo-

# Chemical_Formula:
C2H2O3

# Chemical_Structure:
tbl_chemical:::HMDB00119_ZOOM.png:::119283198928349271

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00119_THUMB.png:::119283198790880517

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
aldehyde; carboxylic acid

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
74.00040

# Molecular_Weight_Avg:
74.03548

# Smiles_String_isomeric:
OC(=O)C=O

# Smiles_String_canonical:
OC(=O)C=O

# KEGG_Compound_ID:
C00048

# BioCyc_ID:
GLYOX

# PubChem_CID:
760

# PubChem_SID:
8027585; 10517586; 10318882; 7853082; 8150776; 8138112; 7887924; 8024942; 827341; 3156891; 3350; 836991; 5558614; 10336274; 828048; 8028475; 2775; 8145625; 88069; 152473; 841603; 838887

# OMIM_ID:
170995; 259900; 260000

# Metagene_ID:
PRIMARY HYPEROXALURIA I, PH1: 184

# BiGG_ID:
33659

# Wikipedia_ID:
Glyoxylic acid

# METLIN_ID:
3213

# Ref_ID:
1261003; 6148211; 11582947; 9767556; 9260660; 3654878; 2369642; 9869358; 16168380; 14742135; 2875046; 1456449; 10409918

# ChEBI_ID:
16891

# CAS_Registry_Number:
298-12-4

# InChI:
InChI=1/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)

# Synthesis_Reference:
Carbon-fluorine bond in compounds of biological interest.     Goldman, Peter.    Nat. Inst. of Arthritis and Metab. Dis.,  Nat. Inst. of Health,  Bethesda,  MD,  USA.    Science (Washington, DC, United States)  (1969),  164(3884),  1123-30.

# Melting_Point:
-93 oC

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
1000.0 mg/mL [MEYLAN,WM et al. (1996)]; 224.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Liquid

# LogP:
Not Available

# LogP_predicted:
-0.59 [Predicted by ALOGPS]; -0.6 [Predicted by PubChem via XLOGP]; -1.40 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Glyoxylic acid Monohydrate:::1132562202162475598

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Glyoxylic_acid.mol:::1132723808125619408

# SDF_File_[Text]:
tbl_chemical:::HMDB00119.sdf:::119283198516631809

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00119.pdb:::119283198653484223

# PDB_ID:
1D8C

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041009_P00_04_HW_1DP_PRESAT_expanded_2.gif:::114460751913335411

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041009_P00_04_HW_1DP_presat.zip:::117771058146333285

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041009_P00_04_HW_1DP_Assigned.png:::114669163322853231

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041009_P00_04_HW_2DHSQC_729.png:::114790100274267860

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041009_P00_04_HW_2DHSQC_729.zip:::114790100275914829

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041009_P00_04_HW_2DHSQC_729_Assigned.png:::115384179893889124

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Glyoxylic acid.gif:::1132732110375584228

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00119_peaks.txt:::115630955549129693

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Glyoxylic acid_C.gif:::1132737688912866264

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00119_peaks.txt:::1156310745614957839

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00119L.png:::117555262424311368; Medium Energy:tbl_ms:::HMDB00119M.png:::11755526780186111; High Energy:tbl_ms:::HMDB00119H.png:::117555271418042584

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from Solubility); mitochondria; peroxisome

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Amniotic Fluid; Blood; Urine

# Concentration_[Normal]:
Urine	1.27 (0.46-3.26)	umol/mmol_creatinine	Adult:>18_yrs_old	Male	Normal	9869358
Urine	1.88 (0.63-3.22)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9869358


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Primary Hyperoxaluria; Primary Hyperoxaluria II (PHII)

# Pathway_Names:
Glycine, serine and threonine metabolism;1,4-Dichlorobenzene degradation;C5-Branched dibasic acid metabolism

# Pathway_Images:
;;

# KEGG_Images:
map00260;map00627;map00660

# Pathway_Graphs:
;;

# Pathway_SBMLs:
;;

# Metabolic_Enzyme_1_ID:
6097

# Metabolic_Enzyme_1_Name:
Maleylacetoacetate isomerase

# Metabolic_Enzyme_1_Synonyms:
MAAI; Glutathione S- transferase zeta 1; GSTZ1-1

# Metabolic_Enzyme_1_Gene_Name:
GSTZ1

# Metabolic_Enzyme_1_Protein_Sequence:
>Maleylacetoacetate isomerase
MQAGKPILYSYFRSSCSWRVRIALALKGIDYKTVPINLIKDRGQQFSKDFQALNPMKQVP
TLKIDGITIHQSLAIIEYLEETRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLK
QVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDL
TPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA

# Metabolic_Enzyme_1_Number_of_Residues:
216

# Metabolic_Enzyme_1_Molecular_Weight:
24182

# Metabolic_Enzyme_1_Theoretical_pI:
8.71

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_1_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_1_Specific_Function:
Bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4- nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T- butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid

# Metabolic_Enzyme_1_Pathway:
map00350  Tyrosine metabolism;
 map00643  Styrene degradation

# Metabolic_Enzyme_1_Reaction:
4-maleylacetoacetate = 4-fumarylacetoacetate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 5.2.1.2;EC 2.5.1.18

# Metabolic_Enzyme_1_GenBank_ID_Protein:
2832731

# Metabolic_Enzyme_1_SwissProt_ID:
MAAI_HUMAN (O43708)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
GSTZ1

# Metabolic_Enzyme_1_Geneatlas_id:
GSTZ1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4643

# Metabolic_Enzyme_1_PDB_ID:
1FW1

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>651 bp
ATGCAGGCGGGGAAGCCCATCCTCTATTCCTATTTCCGAAGCTCCTGCTCATGGAGAGTT
CGAATTGCTCTGGCCTTGAAAGGCATCGACTACAAGACGGTGCCCATCAATCTCATAAAG
GATGGGGGCCAACAGTTTTCTAAGGACTTCCAGGCACTGAATCCTATGAAGCAGGTGCCA
ACCCTGAAGATTGATGGAATCACCATTCACCAGTCACTGGCCATCATTGAGTATCTAGAG
GAGACGCGTCCCACTCCGCGACTTCTGCCTCAGGACCCAAAGAAGAGGGCCAGCGTGCGT
ATGATTTCTGACCTCATCGCTGGTGGCATCCAGCCCCTGCAGAACCTGTCTGTCCTGAAG
CAAGTGGGAGAGGAGATGCAGCTGACCTGGGCCCAGAACGCCATCACTTGTGGCTTTAAC
GCCCTGGAGCAGATCCTACAGAGCACAGCGGGCATATACTGTGTAGGAGACGAGGTGACC
ATGGCTGATCTGTGCTTGGTGCCTCAGGTGGCAAATGCTGAAAGATTCAAGGTGGATCTC
ACCCCCTACCCTACCATCAGCTCCATCAACAAGAGGCTGCTGGTCTTGGAGGCCTTCCAG
GTGTCTCACCCCTGCCGGCAGCCAGATACACCCACTGAGCTGAGGGCCTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AJ001838

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_1_Locus:
14q24.3

# Metabolic_Enzyme_1_SNPs:
rs1046428; rs2234955; rs7972; rs3177427; rs1861887; rs8004561; rs2270422; rs7142535; rs2234738; rs5809822; rs8004558; rs8016187; rs2234737; rs3742739; rs2287395; rs8177546; rs8177551; rs1468951; rs8177555; rs8177552; rs8177550; rs8177559; rs8177547; rs8177548; rs8177557; rs4147578; rs731346; rs2287396; rs888411; rs8177570; rs888410; rs8177573; rs5809824; rs8177571; rs2270423; rs2287397; rs8177562; rs8177569; rs8177565; rs8177567; rs1017186; rs1800199; rs17105715; rs8177549; rs8177575; rs35412338; rs8177556; rs34853065; rs2885855; rs5809823; rs3037047; rs4147579; rs8177554; rs11287763; rs35612979; rs8177560; rs8177558; rs10716979; rs8177553; rs8177561; rs10584256; rs8177566; rs8177568; rs8177563; rs8177572; rs8177564; rs8177574; rs41285488; rs34553858; rs5809825; rs11319759; rs12898118; rs35278065; rs34442366; rs10132619; rs11624726; rs11850771; rs12441; rs2111699; rs2160837; rs2160838; rs2234736; rs2234954; rs2270421; rs2363640; rs2363641; rs2363643; rs3759731; rs3759732; rs3759733; rs3759734; rs4899651; rs6636; rs6637; rs7153544; rs8177535; rs8177537; rs8177538; rs8177539; rs8177544; rs9671248

# Metabolic_Enzyme_1_General_References:
9417084; 9396740; 9925947; 10373324; 12508121; 9531472; 10739172; 11327815

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6878

# Metabolic_Enzyme_2_Name:
Catalase

# Metabolic_Enzyme_2_Synonyms:
Not Available

# Metabolic_Enzyme_2_Gene_Name:
CAT

# Metabolic_Enzyme_2_Protein_Sequence:
>Catalase
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT
KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD
THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE
HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK
NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL

# Metabolic_Enzyme_2_Number_of_Residues:
527

# Metabolic_Enzyme_2_Molecular_Weight:
59757

# Metabolic_Enzyme_2_Theoretical_pI:
7.41

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  catalase activity
 ||
>>>
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide

# Metabolic_Enzyme_2_Pathway:
map00380  Tryptophan metabolism;
 map00680  Methane metabolism

# Metabolic_Enzyme_2_Reaction:
2 H2O2 = O2 + 2 H2O

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00199:Catalase

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.11.1.6

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1228085

# Metabolic_Enzyme_2_SwissProt_ID:
CATA_HUMAN (P04040)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
CAT

# Metabolic_Enzyme_2_Geneatlas_id:
CAT

# Metabolic_Enzyme_2_hgnc_id:
HGNC:1516

# Metabolic_Enzyme_2_PDB_ID:
1F4J

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_2_Gene_Sequence:
>66 bp
ATGGCTGACAGCCGGGATCCCGCCAGCGACCAGATGCAGCACTGGAAGGAGCAGCGGGCC
GCGCAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X04085

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_2_Locus:
11p13

# Metabolic_Enzyme_2_SNPs:
rs17880442; rs11032709; rs769217; rs35677492; rs1049982; rs2234940; rs1050032; rs566979; rs769218; rs511895; rs524167; rs494024; rs1408035; rs560807; rs10488736; rs2284367; rs482322; rs7947841; rs480496; rs11032699; rs2300182; rs2284365; rs7103083; rs499406; rs3758730; rs4755372; rs508370; rs7933285; rs1000343; rs554576; rs2073059; rs11032701; rs17886008; rs4755373; rs484214; rs6484722; rs543701; rs17884666; rs2420389; rs551929; rs480575; rs10836244; rs2179625; rs7113917; rs2268063; rs533425; rs12272630; rs17881488; rs486256; rs17884576; rs2073058; rs11604331; rs17884491; rs7120960; rs1408034; rs524154; rs7109778; rs7101395; rs17881288; rs12269988; rs7126610; rs10836235; rs16925608; rs16925614; rs11824384; rs2284368; rs17883121; rs2420388; rs4756146; rs16925606; rs17884086; rs2284364; rs7930427; rs12803540; rs1408036; rs17268652; rs2284366; rs17881567; rs2300181; rs7928213; rs11032702; rs16925581; rs525938; rs11032700; rs17881921; rs17884095; rs17885743; rs17881476; rs17883793; rs11826620; rs12270780; rs35915891; rs2268064; rs17883592; rs17884725; rs17881482; rs17880673; rs2284369; rs17883544; rs11032703; rs12273124; rs17884248; rs35755143; rs7126640; rs2076556; rs4755374; rs1055981; rs17884335; rs17884518; rs17880274; rs17883699; rs4756148; rs17886200; rs475043; rs564250; rs769214; rs9282626; rs7943316; rs9282627; rs7104301; rs17883920; rs1001179; rs17881029; rs17886350; rs2266625; rs34455645; rs3180560; rs11546300; rs1050028; rs2266629; rs2266619; rs14527; rs2266628; rs35012776; rs34964953; rs34727149; rs3831770; rs17886810; rs35927227; rs7121850; rs17885881; rs17882812; rs17885837; rs17880607; rs17882039; rs17881916; rs17880549; rs34138762; rs28586982; rs34503767; rs36074933; rs515130; rs35099202; rs35849009; rs17881846; rs17887048; rs17881224; rs17884421; rs34840731; rs17881231; rs35340649; rs35292563; rs17884242; rs12286702; rs35034960; rs28733253; rs17887248; rs35791482; rs35703808; rs35648206; rs34808995; rs35386961; rs34420404; rs856714; rs17883483; rs17884804; rs17883367; rs17883534; rs17880160; rs17886672; rs34281397; rs34790990; rs2982523; rs35122257; rs2284370; rs12798927; rs35781217; rs11032707; rs17886592; rs4483566; rs34890123; rs4272763; rs12789374; rs17881734; rs35330036; rs17883434; rs35081167; rs17886155; rs17886248; rs34840787; rs34890990; rs17881192; rs17881586; rs34267165; rs12786539; rs35834969; rs3818354; rs17884443; rs36224415; rs36224416; rs36224102; rs10312; rs10836230; rs10836233; rs10836234; rs11032717; rs1107573; rs11606946; rs12284341; rs12807961; rs12808450; rs1323690; rs1535718; rs1535719; rs1535720; rs1535721; rs16925525; rs2073057; rs208678; rs208679; rs208681; rs208682; rs208683; rs2231828; rs2266624; rs2266630; rs2296144; rs409598; rs554518; rs7109862; rs7114869; rs7118388; rs7928156; rs7941147; rs7944397; rs7949972

# Metabolic_Enzyme_2_General_References:
3755525; 3755526; 11728823; 8282800; 12665801; 6548744; 10666617; 10656833; 11134921

# Metabolic_Enzyme_2_References:
1444337; 3987689; 9272859

# Metabolic_Enzyme_3_ID:
6069

# Metabolic_Enzyme_3_Name:
Serine--pyruvate aminotransferase

# Metabolic_Enzyme_3_Synonyms:
SPT; Alanine-- glyoxylate aminotransferase; AGT

# Metabolic_Enzyme_3_Gene_Name:
AGXT

# Metabolic_Enzyme_3_Protein_Sequence:
>Serinepyruvate aminotransferase
MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEI
KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG
ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLL
LVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF
YLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHG
RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLR
IGLLGCNATRENVDRVTEALRAALQHCPKKKL

# Metabolic_Enzyme_3_Number_of_Residues:
392

# Metabolic_Enzyme_3_Molecular_Weight:
43011

# Metabolic_Enzyme_3_Theoretical_pI:
8.55

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
L-serine + pyruvate = 3-hydroxypyruvate + L- alanine

# Metabolic_Enzyme_3_Pathway:
map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_3_Reaction:
L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00266:Aminotran_5

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.6.1.51;EC 2.6.1.44

# Metabolic_Enzyme_3_GenBank_ID_Protein:
36582

# Metabolic_Enzyme_3_SwissProt_ID:
SPYA_HUMAN (P21549)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
AGXT

# Metabolic_Enzyme_3_Geneatlas_id:
AGXT

# Metabolic_Enzyme_3_hgnc_id:
HGNC:341

# Metabolic_Enzyme_3_PDB_ID:
1H0C

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Peroxisome. Note=Except in some PH1 patients where AGT is found in the mitochondrial matrix

# Metabolic_Enzyme_3_Gene_Sequence:
>1179 bp
ATGGCCTCTCACAAGCTGCTGGTGACCCCCCCCAAGGCCCTGCTCAAGCCCCTCTCCATC
CCCAACCAGCTCCTGCTGGGGCCTGGTCCTTCCAACCTGCCTCCTCGCATCATGGCAGCC
GGGGGGCTGCAGATGATCGGGTCCATGAGCAAGGATATGTACCAGATCATGGACGAGATC
AAGGAAGGCATCCAGTACGTGTTCCAGACCAGGAACCCACTCACACTGGTCATCTCTGGC
TCGGGACACTGTGCCCTGGAGGCCGCCCTGGTCAATGTGCTGGAGCCTGGGGACTCCTTC
CTGGTTGGGGCCAATGGCATTTGGGGGCAGCGAGCCGTGGACATCGGGGAGCGCATAGGA
GCCCGAGTGCACCCGATGACCAAGGACCCTGGAGGCCACTACACACTGCAGGAGGTGGAG
GAGGGCCTGGCCCAGCACAAGCCAGTGCTGCTGTTCTTAACCCACGGGGAGTCGTCCACC
GGCGTGCTGCAGCCCCTTGATGGCTTCGGGGAACTCTGCCACAGGTACAAGTGCCTGCTC
CTGGTGGATTCGGTGGCATCCCTGGGCGGGACCCCCCTTTACATGGACCGGCAAGGCATC
GACATCCTGTACTCGGGCTCCCAGAAGGCCCTGAACGCCCCTCCAGGGACCTCGCTCATC
TCCTTCAGTGACAAGGCCAAAAAGAAGATGTACTCCCGCAAGACGAAGCCCTTCTCCTTC
TACCTGGACATCAAGTGGCTGGCCAACTTCTGGGGCTGTGACGACCAGCCCAGGATGTAC
CATCACACAATCCCCGTCATCAGCCTGTACAGCCTGAGAGAGAGCCTGGCCCTCATTGCG
GAACAGGGCCTGGAGAACAGCTGGCGCCAGCACCGCGAGGCCGCGGCGTATCTGCATGGG
CGCCTGCAGGCACTGGGGCTGCAGCTCTTCGTGAAGGACCCGGCGCTCCGGCTTCCCACA
GTCACCACTGTGGCTGTACCCGCTGGCTATGACTGGAGAGACATCGTCAGCTACGTCATA
GACCACTTCGACATTGAGATCATGGGTGGCCTTGGGCCCTCCACGGGGAAGGTGCTGCGG
ATCGGCCTGCTGGGCTGCAATGCCACCCGCGAGAATGTGGACCGCGTGACGGAGGCCCTG
AGGGCGGCCCTGCAGCACTGCCCCAAGAAGAAGCTGTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X56092

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_3_Locus:
2q36-q37

# Metabolic_Enzyme_3_SNPs:
rs4426527; rs13408961; rs34885252; rs34116584; rs33958047; rs4273214; rs4344931; rs4073369; rs4073370; rs12695032; rs6732985; rs4073597; rs10199038; rs11681134; rs11894759; rs12478859; rs10933640; rs4355101; rs13430507; rs13423821; rs5021686; rs5013752; rs11901056; rs11687303; rs10933641; rs13030904; rs11693280; rs11685698; rs11886288; rs4675876; rs4675875; rs4234095; rs10182575; rs34664134; rs35977912; rs35698882; rs3196760; rs4991357; rs11682457; rs11688815; rs11691745; rs35882315; rs12997245; rs4991356; rs33996129; rs6722479; rs4991354; rs4414673; rs5839789; rs35937797; rs12464426; rs4991360; rs34134404; rs35561942; rs4991355; rs5839787; rs34995778; rs34572785; rs10196315; rs13020254; rs11691886; rs35566646; rs5839788; rs4257395; rs4991359; rs5013751; rs4328626; rs4991361; rs35172778; rs5839786; rs4991358; rs5021687; rs4675793; rs12622523; rs34927888; rs12998301; rs11897804; rs7568864; rs4675877; rs6718131; rs35931917; rs35082207; rs12619921; rs6717643; rs10177846; rs10178744; rs10185214; rs10933510; rs1138103; rs11680732; rs11681382; rs11686679; rs11689640; rs11886874; rs11899555; rs12616061; rs12991730; rs12994627; rs13000529; rs13001584; rs13007644; rs13025495; rs13030611; rs13385816; rs13387029; rs13397515; rs13410652; rs33998315; rs34927891; rs36014033; rs4129624; rs4295000; rs4311055; rs4312490; rs4465762; rs4538195; rs4675792; rs4675869; rs4675871; rs4675872; rs4675874; rs6437372; rs6707763; rs6708304; rs6741220; rs6744422; rs7340215; rs7340501; rs7355583; rs7557279; rs7590032; rs7598309; rs7600847; rs7601670; rs7604393; rs7606856; rs9288742

# Metabolic_Enzyme_3_General_References:
2253628; 1703535; 2363689; 2045108; 2039493; 1349575; 1301173; 8101040; 8507692; 9192270; 10394939; 10862087

# Metabolic_Enzyme_3_References:
10347152; 11330044; 11699734; 15849465

# Metabolic_Enzyme_4_ID:
5772

# Metabolic_Enzyme_4_Name:
Acetylcholinesterase precursor

# Metabolic_Enzyme_4_Synonyms:
AChE

# Metabolic_Enzyme_4_Gene_Name:
ACHE

# Metabolic_Enzyme_4_Protein_Sequence:
>Acetylcholinesterase precursor
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL

# Metabolic_Enzyme_4_Number_of_Residues:
614

# Metabolic_Enzyme_4_Molecular_Weight:
67797

# Metabolic_Enzyme_4_Theoretical_pI:
6.24

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  cholinesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Rapidly hydrolyzes choline released into the synapse

# Metabolic_Enzyme_4_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_4_Reaction:
acetylcholine + H2O = choline + acetate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF08674:AChE_tetra;
PF00135:COesterase

# Metabolic_Enzyme_4_Signals:
1-31

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.1.1.7

# Metabolic_Enzyme_4_GenBank_ID_Protein:
177975

# Metabolic_Enzyme_4_SwissProt_ID:
ACES_HUMAN (P22303)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
ACHE

# Metabolic_Enzyme_4_Geneatlas_id:
ACHE

# Metabolic_Enzyme_4_hgnc_id:
HGNC:108

# Metabolic_Enzyme_4_PDB_ID:
1F8U

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_4_Gene_Sequence:
>1845 bp
ATGAGGCCCCCGCAGTGTCTGCTGCACACGCCTTCCCTGGCTTCCCCACTCCTTCTCCTC
CTCCTCTGGCTCCTGGGTGGAGGAGTGGGGGCTGAGGGCCGGGAGGATGCAGAGCTGCTG
GTGACGGTGCGTGGGGGCCGGCTGCGGGGCATTCGCCTGAAGACCCCCGGGGGCCCTGTC
TCTGCTTTCCTGGGCATCCCCTTTGCGGAGCCACCCATGGGACCCCGTCGCTTTCTGCCA
CCGGAGCCCAAGCAGCCTTGGTCAGGGGTGGTAGACGCTACAACCTTCCAGAGTGTCTGC
TACCAATATGTGGACACCCTATACCCAGGTTTTGAGGGCACCGAGATGTGGAACCCCAAC
CGTGAGCTGAGCGAGGACTGCCTGTACCTCAACGTGTGGACACCATACCCCCGGCCTACA
TCCCCCACCCCTGTCCTCGTCTGGATCTATGGGGGTGGCTTCTACAGTGGGGCCTCCTCC
TTGGACGTGTACGATGGCCGCTTCTTGGTACAGGCCGAGAGGACTGTGCTGGTGTCCATG
AACTACCGGGTGGGAGCCTTTGGCTTCCTGGCCCTGCCGGGGAGCCGAGAGGCCCCGGGC
AATGTGGGTCTCCTGGATCAGAGGCTGGCCCTGCAGTGGGTGCAGGAGAACGTGGCAGCC
TTCGGGGGTGACCCGACATCAGTGACGCTGTTTGGGGAGAGCGCGGGAGCCGCCTCGGTG
GGCATGCACCTGCTGTCCCCGCCCAGCCGGGGCCTGTTCCACAGGGCCGTGCTGCAGAGC
GGTGCCCCCAATGGACCCTGGGCCACGGTGGGCATGGGAGAGGCCCGTCGCAGGGCCACG
CAGCTGGCCCACCTTGTGGGCTGTCCTCCAGGCGGCACTGGTGGGAATGACACAGAGCTG
GTAGCCTGCCTTCGGACACGACCAGCGCAGGTCCTGGTGAACCACGAATGGCACGTGCTG
CCTCAAGAAAGCGTCTTCCGGTTCTCCTTCGTGCCTGTGGTAGATGGAGACTTCCTCAGT
GACACCCCAGAGGCCCTCATCAACGCGGGAGACTTCCACGGCCTGCAGGTGCTGGTGGGT
GTGGTGAAGGATGAGGGCTCGTATTTTCTGGTTTACGGGGCCCCAGGCTTCAGCAAAGAC
AACGAGTCTCTCATCAGCCGGGCCGAGTTCCTGGCCGGGGTGCGGGTCGGGGTTCCCCAG
GTAAGTGACCTGGCAGCCGAGGCTGTGGTCCTGCATTACACAGACTGGCTGCATCCCGAG
GACCCGGCACGCCTGAGGGAGGCCCTGAGCGATGTGGTGGGCGACCACAATGTCGTGTGC
CCCGTGGCCCAGCTGGCTGGGCGACTGGCTGCCCAGGGTGCCCGGGTCTACGCCTACGTC
TTTGAACACCGTGCTTCCACGCTCTCCTGGCCCCTGTGGATGGGGGTGCCCCACGGCTAC
GAGATCGAGTTCATCTTTGGGATCCCCCTGGACCCCTCTCGAAACTACACGGCAGAGGAG
AAAATCTTCGCCCAGCGACTGATGCGATACTGGGCCAACTTTGCCCGCACAGGGGATCCC
AATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAG
TACGTTAGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGC
GCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCCACCGACACGCTCGACGAGGCG
GAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAAC
CAGTTCGACCACTACAGCAAGCAGGATCGCTGCTCAGACCTGTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M55040

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_4_Locus:
7q22

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
2263619; 12853948; 11239002; 8299725; 2714437; 1748670; 1517212; 9640563; 11053835; 8488842

# Metabolic_Enzyme_4_References:
12002439; 2077764; 2782610; 3426523

# Metabolic_Enzyme_5_ID:
6178

# Metabolic_Enzyme_5_Name:
Isocitrate dehydrogenase [NADP], mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
Oxalosuccinate decarboxylase; IDH; NADP(+-specific ICDH; IDP; ICD-M

# Metabolic_Enzyme_5_Gene_Name:
IDH2

# Metabolic_Enzyme_5_Protein_Sequence:
>Isocitrate dehydrogenase NADP, mitochondrial precursor
MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ

# Metabolic_Enzyme_5_Number_of_Residues:
452

# Metabolic_Enzyme_5_Molecular_Weight:
50910

# Metabolic_Enzyme_5_Theoretical_pI:
8.95

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  isocitrate dehydrogenase activity
Function:  isocitrate dehydrogenase (NADP+) activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_5_Specific_Function:
Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex

# Metabolic_Enzyme_5_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00480  Glutathione metabolism;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_5_Reaction:
isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00180:Iso_dh

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.1.1.42

# Metabolic_Enzyme_5_GenBank_ID_Protein:
872121

# Metabolic_Enzyme_5_SwissProt_ID:
IDHP_HUMAN (P48735)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
IDH2

# Metabolic_Enzyme_5_Geneatlas_id:
IDH2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:5383

# Metabolic_Enzyme_5_PDB_ID:
1LWD

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_5_Gene_Sequence:
>1359 bp
ATGGCCGGCTACCTGCGGGTCGTGCGCTCGCTCTGCAGAGCCTCAGGCTCGCGGCCGGCC
TGGGCGCCGGCGGCCCTGACAGCCCCCACCTCGCAAGAGCATCCGCGGCGCCACTATGCC
GACAAAAGGATCAAGGTGGCGAAGCCCGTGGTGGAGATGGATGGTGATGAGATGACCCGT
ATTATCTGGCAGTTCATCAAGGAGAAGCTCATCCTGCCCCACGTGGACATCCAGCTAAAG
TATTTTGACCTCGGGCTCCCAAACCGTGACCAGACTGATGACCAGGTCACCATTGACTCT
GCACTGGCCACCCAGAAGTACAGTGTGGCTGTCAAGTGTGCCACCATCACCCCTGATGAG
GCCCGTGTGGAAGAGTTCAAGCTGAAGAAGATGTGGAAAAGTCCCAATGGAACTATCCGG
AACATCCTGGGGGGGACTGTCTTCCGGGAGCCCATCATCTGCAAAAACATCCCACGCCTA
GTCCCTGGCTGGACCAAGCCCATCACCATTGGCAGGCACGCCCATGGCGACCAGTACAAG
GCCACAGACTTTGTGGCAGACCGGGCCGGCACTTTCAAAATGGTCTTCACCCCAAAAGAT
GGCAGTGGTGTCAAGGAGTGGGAAGTGTACAACTTTCCCGCAGGCGGCGTGGGCATGGGC
ATGTACAACACCGACGAGTCCATCTCAGGTTTTGCGCACAGCTGCTTCCAGTATGCCATC
CAGAAGAAATGGCCGCTGTACATGAGCACCAAGAACACCATACTGAAAGCCTACGATGGG
CGTTTCAAGGACATCTTCCAGGAGATCTTTGACAAGCACTATAAGACCGACTTCGACAAG
AATAAGATCTGGTATGAGCACCGGCTCATTGATGACATGGTGGCTCAGGTCCTCAAGTCT
TCGGGTGGCTTTGTGTGGGCCTGCAAGAACTATGACGGAGATGTGCAGTCAGACATCCTG
GCCCAGGGCTTTGGCTCCCTTGGCCTGATGACGTCCGTCCTGGTCTGCCCTGATGGGAAG
ACGATTGAGGCTGAGGCCGCTCATGGGACCGTCACCCGCCACTATCGGGAGCACCAGAAG
GGCCGGCCCACCAGCACCAACCCCATCGCCAGCATCTTTGCCTGGACACGTGGCCTGGAG
CACCGGGGGAAGCTGGATGGGAACCAAGACCTCATCAGGTTTGCCCAGATGCTGGAGAAG
GTGTGCGTGGAGACGGTGGAGAGTGGAGCCATGACCAAGGACCTGGCGGGCTGCATTCAC
GGCCTCAGCAATGTGAAGCTGAACGAGCACTTCCTGAACACCATGGACTTCCTCGACACC
ATCAAGAGCAACCTGGACAGAGCCCTGGGCAGGCAGTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X69433

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_5_Locus:
15q26.1

# Metabolic_Enzyme_5_SNPs:
rs11540478; rs16943901; rs4932279; rs8034938; rs7167577; rs6496622; rs7177165; rs8030346; rs9672249; rs10520685; rs4932278; rs11630814; rs10459702; rs11853055; rs9972549; rs11073899; rs7178604; rs9972327; rs3934860; rs8028234; rs10852126; rs16943899; rs7177558; rs7182369; rs16943894; rs11630335; rs8038011; rs4932280; rs7176347; rs4283211; rs3207044; rs4280211; rs3207045; rs3207047; rs7177032; rs1802920; rs35595609; rs35229668; rs35664386; rs10459675; rs9652516; rs8031694; rs34664136; rs35477556; rs28458925; rs11638845; rs8028270; rs34506900; rs35222274; rs4548834; rs11367383; rs34936041; rs34409906; rs35717725; rs34807593; rs4369633; rs9652515; rs28508560; rs28611491; rs28397672; rs35845864; rs35789470; rs34687144; rs35474233; rs4548833; rs28407278; rs28524104; rs28817699; rs35069981; rs34813967; rs11397045; rs35633367; rs35207526; rs4932157; rs11316815; rs28755429; rs6496621; rs34120525; rs35474715; rs28664905; rs12912761; rs34116091; rs36118949; rs4462566; rs28795173; rs34281036; rs10622800; rs28592803; rs4516205; rs4537990; rs34405020; rs34552862; rs4932281; rs2970355; rs5814411; rs35833570; rs28547012; rs11298094; rs28692845; rs4539574; rs4341718; rs3207049; rs1142630; rs13380100; rs1064031; rs28727276; rs34123931; rs17523637; rs3207046; rs3207050; rs4932277; rs35788632; rs4570818; rs8026919; rs5020666; rs28489267; rs4316732; rs11545493; rs3207048; rs34380663; rs11073900; rs11632348; rs12443387; rs2939846; rs2939847; rs2939850; rs2970356; rs2970357; rs2970358; rs2970359; rs4553601; rs4561444; rs4577063; rs6496620; rs7168705

# Metabolic_Enzyme_5_General_References:
Not Available

# Metabolic_Enzyme_5_References:
10698750; 12445639; 14595781; 16887020

# Metabolic_Enzyme_6_ID:
6172

# Metabolic_Enzyme_6_Name:
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial precursor

# Metabolic_Enzyme_6_Synonyms:
Phosphoenolpyruvate carboxylase; PEPCK-M

# Metabolic_Enzyme_6_Gene_Name:
PCK2

# Metabolic_Enzyme_6_Protein_Sequence:
>Phosphoenolpyruvate carboxykinase GTP, mitochondrial precursor
MAALYRPGLRLNWHGLSPLGWPSCRSIQTLRVLSGDLGQLPTGIRDFVEHSARLCQPEGI
HICDGTEAENTATLTLLEQQGLIRKLPKYNNCWLARTDPKDVARVESKTVIVTPSQRDTV
PLPPGGARGQLGNWMSPADFQRAVDERFPGCMQGRTMYVLPFSMGPVGSPLSRIGVQLTD
SAYVVASMRIMTRLGTPVLQALGDGDFVKCLHSVGQPLTGQGEPVSQWPCNPEKTLIGHV
PDQREIISFGSGYGGNSLLGKKCFALRIASRLARDEGWLAEHMLILGITSPAGKKALCAA
AFPSACGKTNLAMMRPALPGWKVECVGDDIAWMRFDSEGRLRAINPENGFFGVAPGTSAT
TNPNAMATIQSNTIFTNVAETSDGGVYWEGIDQPLPPGVTVTSWLGKPWKPGDKEPCAHP
NSRFCAPARQCPIMDPAWEAPEGVPIDAIIFGGRRPKGVPLVYEAFNWRHGVFVGRAMRS
ESTAAAEHKGKIIMHDPFAMRPFFGYNFGHYLEHWLSMEGRKGAQLPRIFHVNWFRRDEA
GHFLWPGFGENARVLDWICRRLEGEDSARETPIGLVPKEGALDLSGLRAIDTTQLFSLPK
DFWEQEVRDIRSYLTEQVNQDLPKEVLAELEALERRVHKM

# Metabolic_Enzyme_6_Number_of_Residues:
640

# Metabolic_Enzyme_6_Molecular_Weight:
70638

# Metabolic_Enzyme_6_Theoretical_pI:
7.65

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  guanyl nucleotide binding
Function:  GTP binding
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
Function:  phosphoenolpyruvate carboxykinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  gluconeogenesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_6_Specific_Function:
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO(2)

# Metabolic_Enzyme_6_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00620  Pyruvate metabolism

# Metabolic_Enzyme_6_Reaction:
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00821:PEPCK

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 4.1.1.32

# Metabolic_Enzyme_6_GenBank_ID_Protein:
1403050

# Metabolic_Enzyme_6_SwissProt_ID:
PPCKM_HUMAN (Q16822)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
PCK2

# Metabolic_Enzyme_6_Geneatlas_id:
PCK2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:8725

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_6_Gene_Sequence:
>1923 bp
ATGGCCGCATTGTACCGCCCTGGCCTGCGGCTTAACTGGCATGGGCTGAGCCCCTTGGGC
TGGCCATCATGCCGTAGCATCCAGACCCTGCGAGTGCTTAGTGGAGATCTGGGCCAGCTT
CCCACTGGCATTCGAGATTTTGTAGAGCACAGTGCCCGCCTGTGCCAACCAGAGGGCATC
CACATCTGTGATGGAACTGAGGCTGAGAATACTGCCACACTGACCCTGCTGGAGCAGCAG
GGCCTCATCCGAAAGCTCCCCAAGTACAATAACTGCTGGCTGGCCCGCACAGACCCCAAG
GATGTGGCACGAGTAGAGAGCAAGACGGTGATTGTAACTCCTTCTCAGCGGGACACGGTA
CCACTCCCGCCTGGTGGGGCCTGTGGGCAGCTGGGCAACTGGATGTCCCCAGCTGATTTC
CAGCGAGCTGTGGATGAGAGGTTTCCAGGCTGCATGCAGGGCCGCACCATGTATGTGCTT
CCATTCAGCATGGGTCCTGTGGGCTCCCCGCTGTCCCGCATCGGGGTGCAGCTCACTGAC
TCAGCCTATGTGGTGGCAAGCATGCGTATTATGACCCGACTGGGGACACCTGTGCTTCAG
GCCCTGGGAGATGGTGACTTTGTCAAGTGTCTGCACTCCGTGGGCCAGCCCCTGACAGGA
CAAGGGGAGCCAGTGAGCCAGTGGCCGTGCAACCCAGAGAAAACCCTGATTGGCCACGTG
CCCGACCAGCGGGAGATCATCTCCTTCGGCAGCGGCTATGGTGGCAACTCCCTGCTGGGC
AAGAAGTGCTTTGCCCTACGCATCGCCTCTCGGCTGGCCCGGGATGAGGGCTGGCTGGCA
GAGCACATGCTGATCCTGGGCATCACCAGCCCTGCAGGGAAGAAGGCGCTATGTGCAGCC
GCCTTCCCTAGTGCCTGTGGCAAGACCAACCTGGCTATGATGCGGCCTGCACTGCCAGGC
TGGAAAGTGGAGTGTGTGGGGGATGATATTGCTTGGATGAGGTTTGACAGTGAAGGTCGA
CTCCGGGCCATCAACCCTGAGAACGGCTTCTTTGGGGTTGCCCCTGGTACCTCTGCCACC
ACCAATCCCAACGCCATGGCTACAATCCAGAGTAACACTATTTTTACCAATGTGGCTGAG
ACCAGTGATGGTGGCGTGTACTGGGAGGGCATTGACCAGCCTCTTCCACCTGGTGTTACT
GTGACCTCCTGGCTGGGCAAACCCTGGAAACCTGGTGACAAGGAGCCCTGTGCACATCCC
AACTCTCGATTTTGTGCCCCGGCTCGCCAGTGCCCCATCATGGACCCAGCCTGGGAGGCC
CCAGAGGGTGTCCCCATTGACGCCATCATCTTTGGTGGCCGCAGACCCAAAGGGGTACCC
CTGGTATACGAGGCCTTCAACTGGCGTCATGGGGTGTTTGTGGGCAGAGCCATGCGCTCT
GAGTCCACTGCTGCAGCAGAACACAAAGGGAAGATCATCATGCACGACCCATTTGCCATG
CGGCCCTTTTTTGGCTACAACTTCGGGCACTACCTGGAACACTGGCTGAGCATGGAAGGG
CGCAAGGGGGCCCAGCTGCCCCGTATCTTCCATGTCAACTGGTTCCGGCGTGACGAGGCA
GGGCACTTCCTGTGGCCAGGCTTTGGGGAGAATGCTCGGGTGCTAGACTGGATCTGCCGG
CGGTTAGAGGGGGAGGACAGTGCCCGAGAGACACCCATTGGGCTGGTGCCAAAGGAAGGA
GCCTTGGATCTCAGCGGCCTCAGAGCTATAGACACCACTCAGCTGTTCTCCCTCCCCAAG
GACTTCTGGGAACAGGAGGTTCGTGACATTCGGAGCTACCTGACAGAGCAGGTCAACCAG
GATCTGCCCAAAGAGGTGTTGGCTGAGCTTGAGGCCCTGGAGAGACGTGTGCACAAAATG
TGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
X92720

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_6_Locus:
14q12

# Metabolic_Enzyme_6_SNPs:
Not Available

# Metabolic_Enzyme_6_General_References:
8645161; 9657976

# Metabolic_Enzyme_6_References:
9265774

# Metabolic_Enzyme_7_ID:
7975

# Metabolic_Enzyme_7_Name:
Tyrosine 3-monooxygenase

# Metabolic_Enzyme_7_Synonyms:
Tyrosine 3-hydroxylase; TH

# Metabolic_Enzyme_7_Gene_Name:
TH

# Metabolic_Enzyme_7_Protein_Sequence:
>Tyrosine 3monooxygenase
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTP
RSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPR
ATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVR
QVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEI
AFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNI
PQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCC
HELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQNGEVKAYG
AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYAS
RIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG

# Metabolic_Enzyme_7_Number_of_Residues:
528

# Metabolic_Enzyme_7_Molecular_Weight:
58525

# Metabolic_Enzyme_7_Theoretical_pI:
6.25

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  tyrosine 3-monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  catecholamine metabolism
Process:  catecholamine biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Plays an important role in the physiology of adrenergic neurons

# Metabolic_Enzyme_7_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_7_Reaction:
L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00351:Biopterin_H

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.14.16.2

# Metabolic_Enzyme_7_GenBank_ID_Protein:
37127

# Metabolic_Enzyme_7_SwissProt_ID:
TY3H_HUMAN (P07101)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
TH

# Metabolic_Enzyme_7_Geneatlas_id:
TH

# Metabolic_Enzyme_7_hgnc_id:
HGNC:11782

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>1575 bp
ATGCCCACCCCCGACGCCACCACGCCACAGGCCAAGGGCTTCCGCAGGGCCGTGTCTGAG
CTGGACGCCAAGCAGGCAGAGGCCATCATGGGCGCCCCGGGGCCCAGCCTCACAGGCTCT
CCGTGGCCTGGAACTGCAGCCCCAGCTGCATCCTACACCCCCACCCCAAGGTCCCCGCGG
TTCATTGGGCGCAGGCAGAGCCTCATCGAGGACGCCCGCAAGGAGCGGGAGGCGGCGGTG
GCAGCAGCGGCCGCTGCAGTCCCCTCGGAGCCCGGGGACCCCCTGGAGGCTGTGGCCTTT
GAGGAGAAGGAGGGGAAGGCCGTGCTAAACCTGCTCTTCTCCCCGAGGGCCACCAAGCCC
TCGGCGCTGTCCCGAGCTGTGAAGGTGTTTGAGACGTTTGAAGCCAAAATCCACCATCTA
GAGACCCGGCCCGCCCAGAGGCCGCGAGCTGGGGGCCCCCACCTGGAGTACTTCGTGCGC
CTCGAGGTGCGCCGAGGGGACCTGGCCGCCCTGCTCAGTGGTGTGCGCCAGGTGTCAGAG
GACGTGCGCAGCCCCGCGGGGCCCAAGGTCCCCTGGTTCCCAAGAAAAGTGTCAGAGCTG
GACAAGTGTCATCACCTGGTCACCAAGTTCGACCCTGACCTGGACTTGGACCACCCGGGC
TTCTCGGACCAGGTGTACCGCCAGCGCAGGAAGCTGATTGCTGAGATCGCCTTCCAGTAC
AGGCACGGCGACCCGATTCCCCGTGTGGAGTACACCGCCGAGGAGATTGCCACCTGGAAG
GAGGTCTACACCACGCTGAAGGGCCTCTACGCCACGCACGCCTGCGGGGAGCACCTGGAG
GCCTTTGCTTTGCTGGAGCGCTTCAGCGGCTACCGGGAAGACAATATCCCCCAGCTGGAG
GACGTCTCCCGCTTCCTGAAGGAGCGCACGGGCTTCCAGCTGCGGCCTGTGGCCGGCCTG
CTGTCCGCCCGGGACTTCCTGGCCAGCCTGGCCTTCCGCGTGTTCCAGTGCACCCAGTAT
ATCCGCCACGCGTCCTCGCCCATGCACTCCCCTGAGCCGGACTGCTGCCACGAGCTGCTG
GGGCACGTGCCCATGCTGGCCGACCGCACCTTCGCGCAGTTCTCGCAGGACATTGGCCTG
GCGTCCCTGGGGGCCTCGGATGAGGAAATTGAGAAGCTGTCCACGCTGTCATGGTTCACG
GTGGAGTTCGGGCTGTGTAAGCAGAACGGGGAGGTGAAGGCCTATGGTGCCGGGCTGCTG
TCCTCCTACGGGGAGCTCCTGCACTGCCTGTCTGAGGAGCCTGAGATTCGGGCCTTCGAC
CCTGAGGCTGCGGCCGTGCAGCCCTACCAAGACCAGACGTACCAGTCAGTCTACTTCGTG
TCTGAGAGCTTCAGTGACGCCAAGGACAAGCTCAGGAGCTATGCCTCACGCATCCAGCGC
CCCTTCTCCGTGAAGTTCGACCCGTACACGCTGGCCATCGACGTGCTGGACAGCCCCCAG
GCCGTGCGGCGCTCCCTGGAGGGTGTCCAGGATGAGCTGGACACCCTTGCCCATGCGCTG
AGTGCCATTGGCTAG

# Metabolic_Enzyme_7_GenBank_ID_Gene:
Y00414

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_7_Locus:
11p15.5

# Metabolic_Enzyme_7_SNPs:
rs6356; rs7950050; rs6357; rs34510659; rs11826260; rs3842725; rs10840489; rs11825601; rs4074905; rs12419447; rs2070762; rs7482510; rs3842722; rs7925924; rs7942881; rs11826130; rs7483805; rs7483056; rs4072826; rs4072824; rs7925375; rs7479936; rs4072823; rs3842723; rs10743149; rs10770140; rs3842727; rs7119275; rs7115640; rs10840490; rs10770141; rs11564711; rs10840491; rs3842726; rs11042962; rs10770142; rs28934581; rs28934579; rs28934580; rs1800033; rs36097848; rs3842724; rs1799833; rs11564716; rs34723540; rs6578990; rs11042950; rs3842721; rs35596265; rs11564713; rs11564712; rs36009557; rs4930043; rs36010304; rs7925784; rs35996457; rs4072825; rs35125951; rs11564714; rs35444567; rs34965351; rs11564715; rs11564717; rs10734659; rs11564718; rs1800032; rs10743152; rs10770143; rs10840447; rs10840452; rs10840495; rs10840496; rs10840502; rs11042965; rs11042966; rs11042971; rs11042976; rs11042978; rs11042982; rs11042984; rs11042987; rs11564709; rs11564710; rs11564720; rs2000993; rs28494588; rs28933985; rs3842733; rs3842738; rs3842741; rs3842748; rs3842752; rs3842753; rs3842754; rs3842756; rs3842768; rs3842769; rs3842770; rs3842775; rs4929964; rs4929966; rs4930046; rs5505; rs5506; rs5507; rs6578993; rs689; rs7110099; rs7128097; rs7482891; rs7936868

# Metabolic_Enzyme_7_General_References:
2882428; 2888085; 2887169; 2902075; 2892893; 2896667; 7814018; 7789962; 8528210; 8817341; 9613851; 9754624; 9703425; 10391209; 11246459

# Metabolic_Enzyme_7_References:
12384464; 1973605; 2481804; 3129458

# Metabolic_Enzyme_8_ID:
8070

# Metabolic_Enzyme_8_Name:
Glyoxylate reductase/hydroxypyruvate reductase

# Metabolic_Enzyme_8_Synonyms:
Not Available

# Metabolic_Enzyme_8_Gene_Name:
GRHPR

# Metabolic_Enzyme_8_Protein_Sequence:
>Glyoxylate reductase/hydroxypyruvate reductase
MRPVRLMKVFVTRRIPAEGRVALARAADCEVEQWDSDEPIPAKELERGVAGAHGLLCLLS
DHVDKRILDAAGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLL
TTCRRLPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRF
LYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVF
INISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIGSATHR
TRNTMSLLAANNLLAGLRGEPMPSELKL

# Metabolic_Enzyme_8_Number_of_Residues:
328

# Metabolic_Enzyme_8_Molecular_Weight:
35669

# Metabolic_Enzyme_8_Theoretical_pI:
7.44

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  L-serine metabolism
Process:  L-serine biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_8_Specific_Function:
Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities

# Metabolic_Enzyme_8_Pathway:
map00620  Pyruvate metabolism;
 map00630  Glyoxylate and dicarboxylate metabolism

# Metabolic_Enzyme_8_Reaction:
glycolate + NADP+ = glyoxylate + NADPH + H+

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00389:2-Hacid_dh;
PF02826:2-Hacid_dh_C

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.1.1.79

# Metabolic_Enzyme_8_GenBank_ID_Protein:
6002730

# Metabolic_Enzyme_8_SwissProt_ID:
GRHPR_HUMAN (Q9UBQ7)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
GRHPR

# Metabolic_Enzyme_8_Geneatlas_id:
GRHPR

# Metabolic_Enzyme_8_hgnc_id:
HGNC:4570

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Not Available

# Metabolic_Enzyme_8_Gene_Sequence:
>987 bp
ATGAGACCGGTGCGACTCATGAAGGTGTTCGTCACCCGCAGGATACCCGCCGAGGGTAGG
GTCGCGCTCGCCCGGGCGGCAGACTGTGAGGTGGAGCAGTGGGACTCGGATGAGCCCATC
CCTGCCAAGGAGCTAGAGCGAGGTGTGGCGGGGGCCCACGGCCTGCTCTGCCTCCTCTCC
GACCACGTGGACAAGAGGATCCTGGATGCTGCAGGGGCCAATCTCAAAGTCATCAGCACC
ATGTCTGTGGGCATCGACCACTTGGCTTTGGATGAAATCAAGAAGCGTGGGATCCGAGTT
GGCTACACCCCAGATGTCCTGACAGATACCACCGCCGAACTCGCAGTCTCCCTGCTACTT
ACCACCTGCCGCCGGTTGCCGGAGGCCATCGAGGAAGTGAAGAATGGTGGCTGGACCTCG
TGGAAGCCCCTCTGGCTGTGTGGCTATGGACTCACGCAGAGCACTGTCGGCATCATCGGG
CTGGGGCGCATAGGCCAGGCCATTGCTCGGCGTCTGAAACCATTCGGTGTCCAGAGATTT
CTGTACACAGGGCGCCAGCCCAGGCCTGAGGAAGCAGCAGAATTCCAGGCAGAGTTTGTG
TCTACCCCTGAGCTGGCTGCCCAATCTGATTTCATCGTCGTGGCCTGCTCCTTAACACCT
GCAACCGAGGGACTCTGCAACAAGGACTTCTTCCAGAAGATGAAGGAAACAGCTGTGTTC
ATCAACATCAGCAGGGGCGACGTCGTAAACCAGGACGACCTGTACCAGGCCTTGGCCAGT
GGTAAGATTGCAGCTGCTGGACTGGATGTGACGAGCCCAGAACCACTGCCTACAAACCAC
CCTCTCCTGACCCTGAAGAACTGTGTGATTCTGCCCCACATTGGCAGTGCCACCCACAGA
ACCCGCAACACCATGTCCTTGTTGGCAGCTAACAACTTGCTGGCTGGCCTGAGAGGGGAG
CCGATGCCTAGTGAACTCAAGCTGTAG

# Metabolic_Enzyme_8_GenBank_ID_Gene:
AF134895

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_8_Locus:
9q12

# Metabolic_Enzyme_8_SNPs:
rs12002324; rs309458; rs309461; rs2768659; rs2736664; rs2768662; rs7867764; rs309455; rs309459; rs1887454; rs309453; rs2768658; rs12552734; rs309452; rs309460; rs309457; rs2235096; rs10973333; rs309456; rs309462; rs17885933; rs17411423; rs12683277; rs10973336; rs2768657; rs10973334; rs309454; rs4472607; rs7856656; rs4878690; rs7872991; rs10973329; rs7853540; rs7857159; rs10973327; rs10973328; rs7872720; rs6476631; rs7853526; rs11546642; rs35975284; rs11546644; rs1057507; rs3198078; rs2736669; rs2736662; rs2768660; rs2736670; rs35891798; rs2736673; rs34288288; rs41278295; rs41298174; rs2736665; rs2736660; rs2736667; rs10973335; rs2736671; rs2736661; rs41303225; rs16934118; rs2736663; rs1807410; rs35417895; rs2736666; rs2736674; rs10643023; rs2736668; rs34302950; rs11345501; rs2736672; rs309451; rs13299681; rs10973331; rs10679296; rs34280344; rs10973332; rs35292277; rs34688490; rs34632389; rs10643132; rs5897688; rs927929; rs34510989; rs10814535; rs10973324; rs10973338; rs10973339; rs10973340; rs11793053; rs12348205; rs13300415; rs17411255; rs17502738; rs1802995; rs2840246; rs309450; rs35680410; rs35720597; rs7022431; rs7031029; rs7038960; rs7039333

# Metabolic_Enzyme_8_General_References:
10524214; 10484776; 10679197

# Metabolic_Enzyme_8_References:
15240345; 16653027; 16667010; 7864371

# Metabolic_Enzyme_9_ID:
8079

# Metabolic_Enzyme_9_Name:
Hydroxyacid oxidase 2

# Metabolic_Enzyme_9_Synonyms:
Long chain

# Metabolic_Enzyme_9_Gene_Name:
HAO2

# Metabolic_Enzyme_9_Protein_Sequence:
>Hydroxyacid oxidase 2
MEDKMWSECEGPEMSLVCLTDFQAHAREQLSKSTRDFIEGGADDSITRDDNIAAFKRIRL
RPRYLRDVSEVDTRTTIQGEEISAPICIAPTGFHCLVWPDGEMSTARAAQAAGICYITST
FASCSLEDIVIAAPEGLRWFQLYVHPDLQLNKQLIQRVESLGFKALVITLDTPVCGNRRH
DIRNQLRRNLTLTDLQSPKKGNAIPYFQMTPISTSLCWNDLSWFQSITRLPIILKGILTK
EDAELAVKHNVQGIIVSNHGGRQLDEVLASIDALTEVVAAVKGKIEVYLDGGVRTGNDVL
KALALGAKCIFLGRPILWGLACKGEHGVKEVLNILTNEFHTSMALTGCRSVAEINRNLVQ
FSRL

# Metabolic_Enzyme_9_Number_of_Residues:
364

# Metabolic_Enzyme_9_Molecular_Weight:
40392

# Metabolic_Enzyme_9_Theoretical_pI:
6.70

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_9_Specific_Function:
Not Available

# Metabolic_Enzyme_9_Pathway:
Not Available

# Metabolic_Enzyme_9_Reaction:
Not Available

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF01070:FMN_dh

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 1.1.3.15

# Metabolic_Enzyme_9_GenBank_ID_Protein:
56205790

# Metabolic_Enzyme_9_SwissProt_ID:
Q5QP00_HUMAN (Q5QP00)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
HAO2

# Metabolic_Enzyme_9_Geneatlas_id:
HAO2

# Metabolic_Enzyme_9_hgnc_id:
HGNC:4810

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Not Available

# Metabolic_Enzyme_9_Gene_Sequence:
>1095 bp
ATGGAAGACAAGATGTGGAGTGAATGTGAAGGTCCAGAAATGTCCTTGGTGTGTTTGACA
GACTTTCAGGCCCATGCGCGAGAGCAGCTGTCTAAGTCAACTCGGGATTTTATTGAAGGT
GGAGCAGATGACAGCATCACGCGGGATGACAACATTGCAGCATTTAAAAGAATTCGCCTC
CGTCCGCGGTACCTGAGAGATGTGTCTGAGGTGGACACCAGAACCACAATCCAAGGGGAG
GAGATCAGTGCCCCTATTTGTATCGCACCCACAGGGTTCCACTGCCTTGTCTGGCCTGAT
GGGGAAATGAGCACAGCAAGAGCTGCCCAAGCGGCTGGTATCTGCTACATCACCAGCACA
TTTGCCAGCTGTAGCCTTGAAGACATTGTCATTGCAGCTCCCGAAGGCCTCCGATGGTTC
CAACTCTATGTGCATCCAGACCTGCAGCTGAACAAACAGTTGATCCAGAGGGTAGAATCC
CTAGGTTTCAAAGCTTTGGTAATAACTTTGGATACACCTGTATGTGGCAACAGGCGACAT
GACATTCGAAACCAGTTGAGGAGGAACTTAACACTAACAGATCTTCAATCACCTAAAAAG
GGAAATGCAATACCTTATTTCCAGATGACTCCTATCAGCACTTCTCTCTGCTGGAATGAT
CTCTCCTGGTTTCAGAGCATAACTCGATTGCCCATCATCCTGAAAGGGATTTTGACAAAA
GAGGATGCAGAGTTAGCTGTGAAGCACAATGTCCAGGGTATCATTGTTTCCAACCATGGT
GGGAGGCAGCTTGATGAGGTTCTTGCTTCAATTGATGCTTTGACAGAAGTGGTGGCTGCT
GTAAAGGGGAAAATTGAAGTCTACCTGGATGGCGGGGTCCGAACTGGCAATGATGTGCTG
AAGGCTCTGGCCCTTGGAGCTAAGTGCATTTTTCTTGGGAGACCAATCCTATGGGGCCTT
GCCTGCAAGGGTGAACATGGTGTTAAGGAAGTTTTGAACATTTTAACAAATGAGTTCCAC
ACTTCCATGGCCCTTACAGGCTGCCGGTCGGTCGCTGAGATCAATCGAAACTTGGTCCAG
TTTTCCAGGCTGTAA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AL359553

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_9_Locus:
1p13.3-p13.1

# Metabolic_Enzyme_9_SNPs:
rs34638261; rs2275607; rs35295280; rs2224995; rs3765953; rs3765955; rs3765951; rs3765956; rs10923804; rs7514283; rs6667104; rs3765952; rs10494225; rs6694847; rs6667203; rs10923802; rs6691943; rs7513419; rs12071883; rs6704362; rs7529983; rs3753260; rs4659003; rs3765954; rs3765957; rs10802090; rs17023507; rs17013697; rs1341007; rs2298028; rs6670497; rs6667679; rs2275608; rs1417604; rs7552690; rs2298027; rs12032036; rs6663287; rs3765949; rs3207643; rs6428816; rs10923805; rs7528838; rs2182243; rs17023517; rs3765950; rs11586988; rs9728422; rs10802092; rs6675731; rs3753263; rs3753264; rs3753262; rs6656360; rs3753261; rs12402209; rs6661625; rs41313995; rs41306185; rs4659002; rs11398278; rs12753975; rs12118920; rs12743964; rs34875589; rs12724529; rs7547008; rs36096589; rs35468112; rs35672626; rs35324941; rs35351478; rs12404377; rs35476629; rs3753259; rs4659004; rs11582039; rs10585699; rs11366732; rs41313280; rs6678290; rs34306563; rs28570107; rs41443445; rs3753265; rs3834006; rs3818927; rs3820031; rs10923808; rs12047811; rs12404344; rs12740687; rs1325751; rs1536228; rs17023479; rs1935248; rs2005390; rs2885607; rs35298838; rs3753266; rs3820032; rs6658331; rs6683756; rs879333; rs879334; rs942903; rs947127

# Metabolic_Enzyme_9_General_References:
Not Available

# Metabolic_Enzyme_9_References:
16662922; 2223823

# Metabolic_Enzyme_10_ID:
7812

# Metabolic_Enzyme_10_Name:
OTTHUMP00000030716

# Metabolic_Enzyme_10_Synonyms:
Not Available

# Metabolic_Enzyme_10_Gene_Name:
Not Available

# Metabolic_Enzyme_10_Protein_Sequence:
>
OTTHUMP00000030716MQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYM
LYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRL
WSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVV
GAQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEG
YLVFKQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNV
SGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQ
IREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFS
HRCLTIQ

# Metabolic_Enzyme_10_Number_of_Residues:
409

# Metabolic_Enzyme_10_Molecular_Weight:
45546

# Metabolic_Enzyme_10_Theoretical_pI:
5.69

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
Not Available

# Metabolic_Enzyme_10_Pathway:
Not Available

# Metabolic_Enzyme_10_Reaction:
Not Available

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 6.2.1.1

# Metabolic_Enzyme_10_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_10_SwissProt_ID:
Q5QPG9_HUMAN (Q5QPG9)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
Not Available

# Metabolic_Enzyme_10_Geneatlas_id:
Not Available

# Metabolic_Enzyme_10_hgnc_id:
Not Available

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Not Available

# Metabolic_Enzyme_10_Gene_Sequence:
Not Available

# Metabolic_Enzyme_10_GenBank_ID_Gene:
AL049709

# Metabolic_Enzyme_10_Chromosome_Location:
Not Available

# Metabolic_Enzyme_10_Locus:
Not Available

# Metabolic_Enzyme_10_SNPs:
Not Available

# Metabolic_Enzyme_10_General_References:
Not Available

# Metabolic_Enzyme_10_References:
15806547

# Macromolecular_Interacting_Partner_1_ID:
5565

# Macromolecular_Interacting_Partner_1_Name:
GDH/6PGL endoplasmic bifunctional protein precursor [Includes: Glucose 1-dehydrogenase

# Macromolecular_Interacting_Partner_1_Synonyms:
Hexose-6-phosphate dehydrogenase; 6- phosphogluconolactonase; 6PGL]

# Macromolecular_Interacting_Partner_1_Gene_Name:
H6PD

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>GDH/6PGL endoplasmic bifunctional protein precursor Includes: Glucose 1dehydrogenase
MWNMLIVAMCLALLGCLQAQELQGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGRGHSF
SFHGAALTAPKQGQELMAKALESLSCPKDMAPSHCAEHKDQFLQLSQYRQLKTAEDYQAL
NKDIEAQLQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDH
FSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDGLWNRHHVERVEII
MKETVDAEGRTSFYEEYGVIRDVLQNHLTEVLTLVAMELPHNVSSAEAVLRHKLQVFQAL
RGLQRGSAVVGQYQSYSEQVRRELQKPDSFHSLTPTFAAVLVHIDNLRWEGVPFILMSGK
ALDERVGYARILFKNQACCVQSEKHWAAAQSQCLPRQLVFHIGHGDLGSPAVLVSRNLFR
PSLPSSWKEMEGPPGLRLFGSPLSDYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLL
ASWNFWTPLLESLAHKAPRLYPGGAENGRLLDFEFSSGRLFFSQQQPEQLVPGPGPAPMP
SDFQVLRAKYRESPLVSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQ
QLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHLLQHVRIPYYNIHPMPVHLQQ
RLCAEEDQGAQIYAREISALVANSSFDLVLLGMGADGHTASLFPQSPTGLDGEQLVVLTT
SPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLPHSGQL
VWYMDYDAFLG

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
791

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
88894

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.31

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  6-phosphogluconolactonase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  glucose-6-phosphate 1-dehydrogenase activity
 ||
>>>
Process:  glucose catabolism
Process:  pentose-phosphate shunt
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates

# Macromolecular_Interacting_Partner_1_Pathway:
map00030  Pentose phosphate pathway

# Macromolecular_Interacting_Partner_1_Reaction:
6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF02781:G6PD_C;
PF00479:G6PD_N;
PF01182:Glucosamine_iso

# Macromolecular_Interacting_Partner_1_Signals:
1-19

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 1.1.1.47;EC 3.1.1.31

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
4186038

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
G6PE_HUMAN (O95479)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
H6PD

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
H6PD

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:4795

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum lumen. Note=Microsomes, endoplasmic reticulum lumen

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>2376 bp
ATGTGGAATATGCTCATAGTGGCGATGTGCTTGGCCCTTCTGGGCTGCCTGCAAGCCCAG
GAGCTCCAGGGACATGTCTCCATAATCCTGCTGGGAGCAACTGGGGACCTGGCTAAGAAG
TACTTATGGCAGGGACTGTTCCAGCTGTACCTGGATGAAGCGGGGAGGGGTCACAGTTTT
AGCTTCCATGGAGCTGCTCTGACAGCCCCCAAGCAGGGTCAAGAGCTCATGGCCAAGGCC
CTGGAATCCCTCTCCTGCCCCAAGGACATGGCACCCAGTCACTGTGCAGAGCACAAGGAT
CAGTTCCTGCAGCTGAGCCAGTACCGCCAACTGAAGACGGCCGAGGACTATCAGGCCCTG
AACAAGGACATCGAGGCACAGCTCCAGCACGCAGGCCTCCGGGAGGCTGGCAGGATCTTC
TACTTCTCAGTGCCACCCTTCGCCTATGAAGACATTGCCCGCAACATCAACAGTAGCTGC
CGGCCAGGCCCGGGCGCCTGGCTGCGGGTTGTCCTTGAGAAACCCTTTGGCCATGACCAC
TTCTCAGCCCAGCAGCTGGCCACAGAACTCGGGACCTTTTTCCAGGAGGAGGAGATGTAC
CGGGTGGACCATTACTTAGGCAAGCAGGCTGTGGCGCAGATCCTGCCTTTCCGAGACCAG
AACCGCAAGGCTTTGGACGGCCTCTGGAACCGGCACCATGTGGAGCGGGTGGAGATCATC
ATGAAAGAGACCGTGGATGCTGAAGGCCGCACCAGCTTCTATGAGGAGTACGGTGTCATT
CGCGACGTCCTCCAGAACCATCTGACGGAGGTCCTCACCCTCGTGGCCATGGAGCTGCCC
CACAATGTCAGCAGTGCGGAGGCTGTGCTGCGGCACAAGCTTCAGGTCTTCCAGGCGCTG
CGGGGCCTGCAGAGGGGCAGTGCCGTCGTGGGCCAGTACCAGTCTTACAGTGAGCAGGTG
CGCAGAGAGCTGCAGAAGCCAGACAGCTTCCACAGCCTGACGCCGACCTTCGCAGGTGTC
CTAGTGCACATTGACAACCTTCGCTGGGAGGGCGTGCCTTTCATCCTGATGTCTGGCAAA
GCCTTGGACGAGAGAGTGGGCTACGCTCGGATCTTGTTCAAGAACCAGGCCTGCTGTGTG
CAGAGCGAAAAGCACTGGGCCGCGGCGCAGAGCCAGTGCCTGCCCCGGCAGCTCGTCTTC
CACATCGGCCATGGCGACCTGGGCAGCCCTGCCGTGCTGGTCAGCAGGAACCTGTTCAGG
CCCTCCCTGCCCTCCAGCTGGAAGGAAATGGAGGGACCACCTGGGCTCCGCCTTTTCGGC
AGCCCTCTGTCCGATTACTACGCCTACAGCCCTGTGCGGGAGCGGGACGCCCACTCCGTC
CTCTTATCCCATATCTTCCATGGCCGGAAGAATTTCTTCATCACCACAGAGAACTTGCTG
GCCTCCTGGAACTTCTGGACCCCTCTGCTGGAGAGCCTGGCCCATAAGGCCCCACGCCTC
TACCCTGGAGGAGCTGAGAATGGCCGTCTGTTGGACTTTGAGTTCAGTAGCGGCCGGTTG
TTCTTTTCCCAGCAGCAGCCGGAGCAGCTGGTGCCAGGGCCAGGGCCGGCCCCAATGCCC
AGTGACTTCCAGGTCCTCAGGGCCAAGTACCGAGAGAGCCCGCTGGTCTCCGCCTGGTCC
GAGGAGCTGATCTCTAAGCTGGCTAATGACATCGAGGCCACCGCTGTGCGAGCCGTGCGG
CGCTTTGGCCAGTTCCACCTGGCACTGTCGGGGGGCTCGAGCCCCGTGGCCCTGTTCCAG
CAGCTGGCCACGGCGCACTATGGCTTCCCCTGGGCCCACACGCACCTGTGGCTGGTTGAC
GAGCGCTGCGTCCCACTCTCAGACCCGGAGTCCAACTTCCAGGGCCTGCAGGCCCACCTG
CTGCAGCACGTCCGGATCCCCTACTACAACATCCACCCCATGCCTGTGCACCTGCAGCAG
CGGCTCTGCGCCGAGGAGGACCAGGGCGCCCAGATCTATGCCAGGGAGATCTCAGCCCTG
GTGGCCAACAGCAGCTTCGACCTGGTGCTGCTGGGCATGGGTGCCGACGGGCACACAGCC
TCCCTCTTCCCACAGTCACCCACTGGCCTGGATGGCGAGCAGCTGGTCGTGCTGACCACG
AGCCCCTCCCAGCCACACCGCCGCATGAGCCTTAGCCTGCCTCTCATCAACCGCGCCAAG
AAGGTGGCAGTCCTGGTCATGGGCAGGATGAAGCGTGAGATCACCACGCTGGTGAGCCGG
GTGGGCCATGAGCCCAAGAAGTGGCCCATCTCGGGTGTCCTGCCGCACTCCGGCCAGCTG
GTGTGGTACATGGACTACGACGCCTTCCTGGGATGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AJ012590

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_1_Locus:
1p36

# Macromolecular_Interacting_Partner_1_SNPs:
rs6688832; rs17368528; rs35404275; rs34603401; rs35525021; rs7524046; rs9434743; rs9434742; rs11121350; rs35301166; rs1294014; rs11807816; rs2268175; rs12314; rs1294015; rs2239561; rs2268176; rs11121354; rs11121356; rs17368633; rs11121355; rs2268173; rs2071931; rs9434747; rs17033642; rs1142687; rs11121349; rs12405956; rs6685399; rs4908830; rs1294011; rs9434745; rs9435159; rs9434729; rs12126056; rs2268172; rs11588606; rs1142672; rs2239560; rs732950; rs731183; rs3753165; rs1294010; rs3753164; rs2268169; rs3753163; rs2268170; rs6662509; rs11804534; rs763180; rs11809790; rs2310925; rs10864404; rs2311051; rs11806000; rs3765959; rs10864403; rs12082862; rs7526864; rs9435151; rs7514387; rs6577564; rs11801562; rs9434725; rs7522207; rs35610691; rs34274595; rs12118991; rs35668164; rs17368556; rs35511555; rs34580447; rs35863691; rs7412488; rs36094664; rs34082738; rs34448374; rs36058755; rs3207298; rs33954071; rs3207317; rs3752547; rs5772361; rs41280760; rs9434726; rs35833857; rs12728837; rs4908831; rs1065216; rs3207316; rs3057978; rs11588618; rs35071335; rs41280764; rs9435162; rs2268174; rs9435144; rs35341128; rs34967254; rs9435148; rs34715803; rs1142686; rs1142671; rs9435161; rs1138467; rs12144045; rs34078161; rs12403063; rs1138468; rs1142675; rs35486518; rs3206225; rs1142689; rs9435163; rs6697931; rs1294016; rs35600947; rs9434746; rs41280762; rs2268171; rs6658895; rs12040818; rs1142688; rs9435164; rs1142690; rs34854341; rs9434737; rs36065021; rs1294009; rs5772359; rs12039626; rs9435158; rs1890684; rs34931714; rs12076525; rs2097519; rs763179; rs28548609; rs28665681; rs34308839; rs12083129; rs10449320; rs3861753; rs9434736; rs12032814; rs11805951; rs9435152; rs34764359; rs28496367; rs35492379; rs9435156; rs9434732; rs11804519; rs3765958; rs5772358; rs9435155; rs12042692; rs9434738; rs743972; rs35063052; rs12039625; rs2185298; rs12738271; rs2095907; rs4601607; rs34149245; rs6680990; rs9435167; rs9435166; rs7523498; rs35587892; rs7523400; rs1003369; rs1004920; rs10489436; rs10746487; rs11590326; rs12072683; rs12093524; rs12093571; rs12403829; rs1294012; rs2097520; rs2105225; rs2871656; rs34870859; rs3753271; rs4908832; rs6688233; rs7517538; rs916379; rs916380; rs916381; rs916382; rs916383; rs916384; rs916385; rs916386; rs9434723; rs9435168; rs9435179; rs946599; rs946602

# Macromolecular_Interacting_Partner_1_General_References:
10349511

# Macromolecular_Interacting_Partner_1_References:
2896226

# Macromolecular_Interacting_Partner_2_ID:
5485

# Macromolecular_Interacting_Partner_2_Name:
Dopamine beta-hydroxylase precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Dopamine beta- monooxygenase

# Macromolecular_Interacting_Partner_2_Gene_Name:
DBH

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Dopamine betahydroxylase precursor
MREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYHIPLDPEGSLELSWNVSYTQEAIHF
QLLVRRLKAG
VLFGMSDRGELENADLVVLWTDGDTAYFADAWSDQKGQIHLDPQQDYQL
LQVQRTPEGLTLLFKRPFGTC
DPKDYLIEDGTVHLVYGILEEPFRSLEAINGSGLQMGL
QRVQLLKPNIPEPELPSDACTMEVQAPNIQIP
SQETTYWCYIKELPKGFSRHHIIKYEP
IVTKGNEALVHHMEVFQCAPEMDSVPHFSGPCDSKMKPDRLNY
CRHVLAAWALGAKAFY
YPEEAGLAFGGPGSSRYLRLEVHYHNPLVIEGRNDSSGIRLYYTAKLRRFNAGI
MELGL
VYTPVMAIPPRETAFILTGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKVVTVLVRDGR
EWEIV
NQDNHYSPHFQEIRMLKKVVSVHPGDVLITSCTYNTEDRELATVGGFGILEEMC
VNYVHYYPQTQLELCK
SAVDAGFLQKYFHLINRFNNEDVCTCPQASVSQQFTSVPWNSF
NRDVLKALYSFAPISMHCNKSSAVRFQ
GEWNLQPLPKVISTLEEPTPQCPTSQGRSPAG
PTVVSIGGGKG

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
603

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
67614

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.31

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
Function:  dopamine beta-monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  catecholamine metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  histidine family amino acid metabolism
Process:  histidine metabolism
Process:  histidine catabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Conversion of dopamine to noradrenaline

# Macromolecular_Interacting_Partner_2_Pathway:
map00350  Tyrosine metabolism

# Macromolecular_Interacting_Partner_2_Reaction:
3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF03712:Cu2_monoox_C;
PF01082:Cu2_monooxygen;
PF03351:DOMON

# Macromolecular_Interacting_Partner_2_Signals:
1-25

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
EC 1.14.17.1

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
30474

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
DOPO_HUMAN (P09172)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
DBH

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
DBH

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:2689

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cytoplasmic vesicle; secretory vesicle; chromaffin granule. Cytoplasmic vesicle; secretory vesicle; chromaffin granule; chromaffin granule membrane. Note=Exists both in a soluble form (in chromaffin granules) and as membrane bound (the membrane bound form is anchored by an uncleaved signal peptide)

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1812 bp

ATGCGGGAGGCAGCCTTCATGTACAGCACAGCAGTGGCCATCTTCCTGGTCATCCTGGT
GGCCGCACTGC
AGGGCTCGGCTCCCCGTGAGAGCCCCCTCCCCTATCACATCCCCCTGG
ACCCGGAGGGGTCCCTGGAGCT
CTCATGGAATGTCAGCTACACCCAGGAGGCCATCCAT
TTCCAGCTCCTGGTGCGGAGGCTCAAGGCTGGC
GTCCTGTTTGGGATGTCCGACCGTGG
CGAGCTTGAGAACGCAGATCTCGTGGTGCTCTGGACCGATGGGG
ACACTGCCTATTTTG
CGGACGCCTGGAGTGACCAGAAGGGGCAGATCCACCTGGATCCCCAGCAGGACTA
CCAG
CTGCTGCAGGTGCAGAGGACCCCAGAAGGCCTGACCCTGCTTTTCAAGAGGCCCTTTGGC
ACCTGC
GACCCCAAGGATTACCTCATTGAAGACGGCACTGTCCACTTGGTCTACGGGAT
CCTGGAGGAGCCGTTCC
GGTCACTGGAGGCCATCAACGGCTCGGGCCTGCAGATGGGGC
TGCAGAGGGTGCAGCTCCTGAAGCCCAA
TATCCCCGAACCGGAGTTGCCCTCAGACGCG
TGCACCATGGAGGTCCAAGCTCCCAATATCCAGATCCCC
AGCCAGGAGACCACGTACTG
GTGCTACATTAAGGAGCTTCCAAAGGGCTTCTCTCGGCACCACATTATCA
AGTACGAGC
CCATCGTCACCAAGGGCAATGAGGCCCTTGTCCACCACATGGAAGTCTTCCAGTGCGCCC
C
CGAGATGGACAGCGTCCCCCACTTCAGCGGGCCCTGCGACTCCAAGATGAAACCCGAC
CGCCTCAACTAC
TGCCGCCACGTGCTGGCCGCCTGGGCCCTGGGTGCCAAGGCATTTTA
CTACCCAGAGGAAGCCGGCCTTG
CCTTCGGGGGTCCAGGGTCCTCCAGATATCTCCGCC
TGGAAGTTCACTACCACAACCCACTGGTGATAGA
AGGACGAAACGACTCCTCAGGCATC
CGCTTGTACTACACAGCCAAGCTGCGGCGCTTCAACGCGGGGATC
ATGGAGCTGGGACT
GGTGTACACGCCAGTGATGGCCATTCCACCACGGGAGACCGCCTTCATCCTCACTG
GCT
ACTGCACGGACAAGTGCACCCAGCTGGCACTGCCTCCCTCCGGGATCCACATCTTCGCCT
CTCAGCT
CCACACACACCTGACTGGGAGAAAGGTGGTCACAGTGCTGGTCCGGGACGGC
CGGGAGTGGGAGATCGTG
AACCAGGACAATCACTACAGCCCTCACTTCCAGGAGATCCG
CATGTTGAAGAAGGTCGTGTCGGTCCATC
CGGGAGATGTGCTCATCACCTCCTGCACGT
ACAACACGGAAGACCGGGAGCTGGCCACAGTGGGGGGCTT
CGGGATCCTGGAGGAGATG
TGTGTCAACTACGTGCACTACTACCCCCAGACGCAGCTGGAGCTCTGCAAG
ACGGCTGT
GGACGCCGGCTTCCTGCAGAAGTACTTCCACCTCATCAACAGGTTCAACAACGAGGATGT
CT
GCACCTGCCCTCAGGCGTCCGTGTCTCAGCAGTTCACCTCTGTTCCCTGGAACTCCT
TCAACCGCGACGT
ACTGAAGGCCCTGTACAGCTTCGCGCCCATCTCCATGCACTGCAAC
AAGTCCTCAGCCGTCCGCTTCCAG
GGTGAATGGAACCTGCAGCCCCTGCCCAAGGTCAT
CTCCACACTGGAAGAGCCCACCCCACAGTGCCCCA
CCAGCCAGGGCCGAAGCCCTGCTG
GCCCCACCGTTGTCAGCATTGGTGGGGGCAAAGGCTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
X13255

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_2_Locus:
9q34

# Macromolecular_Interacting_Partner_2_SNPs:
rs5324; rs5320; rs4531; rs5325; rs1108580; rs77905; rs5322; rs5318; rs2519154; rs2797849; rs1541333; rs6479643; rs1611126; rs1108581; rs7035577; rs2797853; rs7876027; rs1611122; rs1611130; rs1611124; rs3025399; rs12343735; rs3025405; rs2797852; rs1541332; rs3025383; rs2519143; rs1611120; rs1611128; rs1611123; rs1611119; rs7862391; rs3025411; rs3025395; rs9657707; rs3025391; rs2519151; rs3025382; rs2007153; rs2797855; rs2283123; rs2283124; rs3025388; rs2519155; rs2873804; rs1548364; rs80858; rs1611125; rs2797851; rs739398; rs3025390; rs3025410; rs129911; rs10993947; rs2283122; rs129913; rs3025413; rs1548367; rs10121827; rs3025401; rs12003344; rs3025387; rs3025403; rs2519153; rs2797854; rs7870239; rs3025393; rs129910; rs7864658; rs2005663; rs3025404; rs3025406; rs1611127; rs2797850; rs3025408; rs3739885; rs129908; rs2519157; rs129909; rs1611118; rs2519152; rs13284520; rs3025392; rs2519144; rs1611114; rs1611115; rs129883; rs129915; rs12002610; rs3025379; rs1611116; rs13306301; rs41316996; rs2797848; rs5319; rs5323; rs3025380; rs13306306; rs5321; rs13306303; rs17851478; rs35465867; rs3025400; rs35043556; rs3739886; rs35067824; rs3025381; rs28419319; rs3025415; rs1548365; rs28481752; rs5901024; rs3081166; rs13306307; rs3025385; rs1611129; rs35246072; rs12001868; rs2519156; rs35528158; rs11278217; rs11283016; rs13293282; rs3025428; rs34469151; rs13306302; rs3025430; rs35806215; rs35682711; rs28662126; rs7032535; rs34932746; rs12003763; rs3025416; rs3025427; rs3025384; rs3025426; rs1548366; rs3025389; rs4333676; rs3025398; rs28738882; rs13306308; rs1548368; rs129912; rs3025386; rs7027680; rs28698922; rs1611121; rs35688529; rs12005180; rs3025396; rs5901023; rs3025414; rs28534474; rs3025407; rs13306305; rs3025402; rs3025429; rs3025409; rs35808071; rs3025394; rs3025412; rs34553440; rs34242880; rs13298385; rs34701710; rs34498190; rs3025377; rs1611117; rs12684659; rs3025433; rs10993904; rs3025432; rs13285918; rs3025378; rs2797847; rs1076150; rs1076153; rs10993885; rs10993886; rs10993948; rs10993949; rs10993950; rs12337651; rs129882; rs129884; rs129885; rs129888; rs129914; rs129916; rs129917; rs129918; rs129919; rs129921; rs129922; rs129923; rs129924; rs129925; rs129926; rs129928; rs129929; rs129930; rs129931; rs17150766; rs1989787; rs2073833; rs2073835; rs2073836; rs2073837; rs2097628; rs2519145; rs2519147; rs2519148; rs2519149; rs2519764; rs2519765; rs3025369; rs3025370; rs3025371; rs3025372; rs3025373; rs3025374; rs3025375; rs3025376; rs3025417; rs3025418; rs3025419; rs3025421; rs3025422; rs3025423; rs3025424; rs3025425; rs3025431; rs3025434; rs3025435; rs3025436; rs3025437; rs3025438; rs3025439; rs3025440; rs3025441; rs3025443; rs6271; rs7043939; rs732833; rs7851898; rs7859358; rs9409875

# Macromolecular_Interacting_Partner_2_General_References:
2922261; 3443096; 8546710; 10490716; 10391209; 10391210; 11857564

# Macromolecular_Interacting_Partner_2_References:
2480372; 2682387; 7912656

# Macromolecular_Interacting_Partner_3_ID:
7831

# Macromolecular_Interacting_Partner_3_Name:
Neuropeptide Y precursor [Contains: Neuropeptide Y

# Macromolecular_Interacting_Partner_3_Synonyms:
Neuropeptide tyrosine; NPY; C-flanking peptide of NPY; CPON]

# Macromolecular_Interacting_Partner_3_Gene_Name:
NPY

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Neuropeptide Y precursor Contains: Neuropeptide 
YMLGNKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDMARYYSALRHYINLI
TRQRYGKRSSPETLISDLLMRESTENVPRTRLEDPAMW

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
97

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
10852

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
7.34

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00159:Hormone_3

# Macromolecular_Interacting_Partner_3_Signals:
1-28

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
189274

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
NPY_HUMAN (P01303)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
NPY

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
NPY

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:7955

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>294 bp
ATGCTAGGTAACAAGCGACTGGGGCTGTCCGGACTGACCCTCGCCCTGTCCCTGCTCGTG
TGCCTGGGTGCGCTGGCCGAGGCGTACCCCTCCAAGCCGGACAACCCGGGCGAGGACGCA
CCAGCGGAGGACATGGCCAGATACTACTCGGCGCTGCGACACTACATCAACCTCATCACC
AGGCAGAGATATGGAAAACGATCCAGCCCAGAGACACTGATTTCAGACCTCTTGATGAGA
GAAAGCACAGAAAATGTTCCCAGAACTCGGCTTGAAGACCCTGCAATGTGGTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
K01911

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_3_Locus:
7p15.1

# Macromolecular_Interacting_Partner_3_SNPs:
rs16139; rs5572; rs5574; rs9785023; rs2229966; rs16478; rs16140; rs16141; rs16142; rs5576; rs16143; rs16144; rs3025123; rs16145; rs16146; rs13235940; rs16129; rs16477; rs16131; rs16138; rs16127; rs16476; rs3025118; rs3779477; rs1468271; rs16133; rs16137; rs16130; rs3025115; rs6950937; rs3025121; rs4719762; rs3757680; rs6977705; rs16135; rs16132; rs6951110; rs3025120; rs6977736; rs16147; rs16148; rs16149; rs16124; rs2189495; rs2390964; rs7807047; rs16479; rs16475; rs16125; rs16126; rs17149106; rs3857724; rs3025124; rs1859290; rs10551063; rs3857723; rs1859291; rs5571; rs1042552; rs3025122; rs13235842; rs13235938; rs36083509; rs3025113; rs13235944; rs2390966; rs13235935; rs2390965; rs2390967; rs5575; rs10693218; rs4722343; rs7791591; rs11575889; rs3757681; rs35016178; rs16136; rs3025119; rs35926284; rs10693219; rs3025117; rs35313836; rs16128; rs4382369; rs10701265; rs3779476; rs3025116; rs13306005; rs1468272; rs6971226; rs11765363; rs10701264; rs35494761; rs36227310; rs36227594; rs3037354; rs36227311; rs1013851; rs10256432; rs1073317; rs10951003; rs12111912; rs12700523; rs12700524; rs12700525; rs16105; rs16106; rs16107; rs16108; rs16109; rs16110; rs16111; rs16112; rs16113; rs16114; rs16115; rs16116; rs16117; rs16118; rs16119; rs16120; rs16121; rs16122; rs16123; rs16468; rs16469; rs16470; rs16471; rs16472; rs16473; rs16474; rs17149144; rs2390963; rs2722382; rs3025107; rs3025108; rs3025109; rs3025110; rs3025111; rs3025112; rs3905497; rs4719763; rs6461790; rs7800861

# Macromolecular_Interacting_Partner_3_General_References:
6589611; 2427515; 3753985; 12853948; 3839058; 1425680; 9008359

# Macromolecular_Interacting_Partner_3_References:
12384464; 12574668; 2897231; 7559158

# Macromolecular_Interacting_Partner_4_ID:
8617

# Macromolecular_Interacting_Partner_4_Name:
UEVLD protein

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
UEVLD

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>UEVLD protein
MEFDCEGLRRLLGKYKFRDLTVEELRNVNVFFPHFKYSMDTYGNTYNIPIRFWILDSHPF
APPICFLKPTANMGILVGKHVDAQGRIYLPYLQNWSHPKSVIVGLIKEMIAKFQEELPMY
SLSSSDEARQVDLLAYIAKITEGVSDTNSKSWANHENKTVNKITVVGGGELGIACTLAIS
AKGIADRLVLLDLSEGTKGATMDLEIFNLPNVEISKDLSASAHSKVVIFTVNSLGSSQSY
LDVVQSNVDMFRALVPALGHYSQHSVLLVASQPVEIMTYVTWKLSTFPANRVIGIGCNLD
SQRLQYIITNVLKAQTSGKEVWVIGEQGEDKVLTWSGQEEVVSHTSQVQLSNRDIMI

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
357

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
39778

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.42

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
 Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
 Process:  cellular physiological process
Process:  transport
Process:  protein transport
Process:  ubiquitin cycle
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_4_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00056:Ldh_1_N
PF05743:UEV

# Macromolecular_Interacting_Partner_4_Signals:
Not Available

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
40555769

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
Q6P2F0_HUMAN (Q6P2F0)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
UEVLD

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
UEVLD

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:30866

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1074 bp
ATGGAGTTCGACTGCGAGGGCCTGAGACGGCTGCTTGGCAAGTACAAGTTCAGGGACCTA
ACTGTGGAAGAACTAAGGAATGTAAATGTATTTTTCCCACATTTCAAATATTCCATGGAC
ACCTATGGTAATACATATAACATACCAATTCGTTTCTGGATTTTGGATTCTCACCCTTTC
GCTCCCCCTATTTGCTTCTTGAAGCCAACTGCAAATATGGGAATCTTAGTCGGAAAACAT
GTGGATGCTCAAGGCAGAATATATTTGCCCTATCTCCAAAACTGGAGCCATCCTAAATCT
GTCATTGTTGGATTAATTAAAGAAATGATTGCCAAGTTTCAAGAGGAACTTCCCATGTAT
TCTCTATCATCATCTGATGAGGCACGGCAGGTAGACTTGCTAGCCTATATTGCAAAAATC
ACTGAAGGTGTTTCAGATACAAATTCAAAGAGCTGGGCAAATCATGAGAATAAAACAGTC
AATAAAATTACTGTGGTTGGAGGTGGAGAACTCGGTATTGCCTGCACATTAGCAATTTCA
GCAAAGGGTATTGCAGACAGGCTTGTCCTCTTAGACCTCTCAGAAGGGACTAAAGGAGCC
ACGATGGACCTTGAAATCTTCAACCTTCCTAATGTGGAGATCAGCAAAGATTTGTCTGCC
TCTGCTCATTCCAAGGTGGTGATCTTCACAGTCAACTCTTTGGGTAGTTCTCAGTCGTAC
CTTGATGTGGTACAGAGCAATGTGGATATGTTCAGAGCCCTTGTCCCAGCTCTGGGACAT
TATAGTCAACACAGTGTCCTGCTCGTTGCATCTCAACCAGTGGAAATCATGACCTATGTA
ACATGGAAACTGAGTACATTTCCTGCAAATCGAGTGATCGGAATTGGATGTAATCTGGAT
TCACAGAGATTACAGTATATTATTACAAATGTTTTGAAGGCACAGACTTCAGGCAAAGAA
GTATGGGTTATTGGCGAGCAAGGAGAAGACAAAGTGCTCACATGGAGTGGCCAAGAAGAA
GTAGTGAGTCATACCTCTCAAGTGCAGCTGTCCAACAGGGATATTATGATATAA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
BC064566

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_4_Locus:
11p15.1

# Macromolecular_Interacting_Partner_4_SNPs:
rs10500835; rs34242612; rs4756952; rs7950602; rs7107057; rs4756951; rs6486434; rs10832940; rs7105889; rs7109314; rs2305166; rs10741747; rs11024718; rs11024717; rs11024715; rs7928508; rs10766485; rs4756949; rs4756950; rs16935539; rs11024716; rs2271080; rs7942733; rs10741745; rs2271079; rs12577416; rs12420702; rs16935575; rs12577346; rs6486435; rs7119085; rs11024706; rs10832943; rs2305167; rs11822477; rs12577619; rs11024711; rs7951508; rs16935543; rs12418907; rs11024709; rs1857907; rs10219146; rs7952284; rs11024725; rs10832942; rs4757672; rs7130163; rs12224694; rs7101733; rs16935538; rs11024719; rs7108487; rs7483340; rs11024722; rs7109496; rs10832946; rs17392588; rs12420882; rs12225461; rs4756948; rs7102116; rs11825249; rs10219166; rs7940645; rs12421803; rs10741746; rs16935559; rs11024723; rs12419223; rs12225037; rs10832947; rs10832944; rs16935541; rs12803251; rs12418726; rs10766486; rs11024724; rs7107204; rs16935557; rs12049912; rs12289644; rs10832941; rs7116316; rs3781639; rs10832945; rs4623881; rs7106180; rs12289223; rs7926511; rs13377281; rs33991194; rs193330; rs11445836; rs968711; rs12794725; rs35449210; rs10638102; rs11024713; rs34853816; rs12049909; rs11024703; rs34081721; rs34109550; rs35749759; rs12796224; rs33928228; rs3214765; rs4756947; rs34523639; rs7948475; rs12796202; rs28607050; rs4417245; rs12790354; rs11600760; rs10683299; rs12795883; rs35059773; rs12049851; rs7119501; rs35960383; rs7934311; rs968712; rs11024705; rs34474192; rs34736014; rs12790143; rs11024726; rs35798683; rs11024712; rs34170647; rs12807106; rs34286769; rs34951254; rs35410505; rs12792924; rs35715013; rs12280959; rs35038497; rs12225251; rs11449292; rs36022682; rs11024704; rs35032055; rs12278992; rs35875343; rs5790040; rs12795875; rs35900814; rs12223260; rs11024721; rs35864596; rs12226584; rs11024714; rs34120372; rs11600244; rs34327848; rs36054394; rs35906676; rs35944144; rs34900962; rs4757671; rs34888550; rs35110669; rs11394988; rs3837379; rs7116220; rs34434085; rs34297128; rs10540605; rs35315027; rs3832729; rs34999373; rs11024720; rs35047705; rs35274706; rs34545423; rs11602888; rs34585786; rs11603372; rs12574808; rs35702732; rs12421881; rs11302053; rs34139368; rs35384688; rs12804077; rs12290527; rs34587461; rs34646785; rs11443134; rs34386323; rs11602699; rs34857682; rs34561317; rs11024710; rs12222154; rs35537932; rs10734260; rs4757670; rs34226030; rs10444226; rs11024701; rs12287275; rs12785294; rs1395319; rs1395320; rs1530565; rs1547497; rs1857908; rs1857909; rs1979051; rs1983124; rs2088184; rs2121386; rs2174614; rs2292177; rs2292178; rs2292179; rs3802965; rs3802966; rs4436523; rs4757673; rs6416020; rs7931630

# Macromolecular_Interacting_Partner_4_General_References:
12477932

# Macromolecular_Interacting_Partner_4_References:
Not Available

End of HMDB00119

Beginning of HMDB00121
# Accession_No:
HMDB00121

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-02 16:26:00

# biospider_lastupdate:
2007-04-18 12:46:18

# Common_Name:
Folic acid

# Description:
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid, being biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase. These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylated tRNA, and generate and use formate. Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.

# Synonyms:
Acifolic; Cytofol; Dosfolat B activ; Folacid; Folacin; Folate; Folbal; Folcidin; Foldine; Folettes; Foliamin; Folic acid; Folicet; Folipac; Folsan; Folsaure; Folsav; Folvite; Incafolic; Liver Lactobacillus casei factor; Millafol; Pteroyl-L-glutamate; Pteroyl-L-glutamic acid; Pteroyl-L-monoglutamate; Pteroyl-L-monoglutamic acid; Pteroylglutamate; Pteroylglutamic acid; Pteroylmonoglutamic acid; Vitamin M

# Chemical_IUPAC_Name:
2-[[4-[(2-amino-4-hydroxy-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

# Chemical_Formula:
C19H19N7O6

# Chemical_Structure:
tbl_chemical:::HMDB00121_ZOOM.png:::119283199964568425

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00121_THUMB.png:::119283199754425369

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Vitamins

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
oxo(het)arene; secondary carboxylic acid amide; secondary amine; primary amine; heterocyclic compound; primary aromatic amine; carboxylic acid; aromatic compound; secondary aliphatic/aromatic amine (alkylarylamine

# Taxonomy_Biofunction:
Essential vitamins; DNA component; Enzyme co-factor; Component of Cyanoamino acid metabolism; Component of Folate biosynthesis; Component of Glycine, serine and threonine metabolism; Component of Glyoxylate and dicarboxylate metabolism; Component of Methane metabolism; Component of Pyrimidine metabolism

# Taxonomy_Source:
Exogenous

# Molecular_Weight:
441.13968

# Molecular_Weight_Avg:
441.39746

# Smiles_String_isomeric:
NC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=CN=C2N1

# Smiles_String_canonical:
NC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)=CN=C2N1

# KEGG_Compound_ID:
C00504

# BioCyc_ID:
FOLATE

# PubChem_CID:
6037

# PubChem_SID:
11112150; 829572; 831381; 832102; 11490565; 835597; 11364275; 831571; 11485093; 10318222; 11360908; 826381; 841329; 584223; 7847138; 834516; 148901; 3787; 11366837; 837484; 11377561; 832091; 831633; 11369399; 10321330; 8149795; 7887539; 7854158; 837196; 7887399; 11489275; 831566; 831664; 11537760; 8144505; 7979297; 11495195; 11461880; 11335669; 11375360; 11371658; 836500; 11493565; 831592; 837689; 835744; 832103

# OMIM_ID:
136610; 136630; 229050; 229100; 236200; 236250; 309548; 601634; 601775; 603174; 608866

# Metagene_ID:
Not Available

# BiGG_ID:
35180

# Wikipedia_ID:
Folic acid

# METLIN_ID:
246

# Ref_ID:
15523939; 9808640; 15321809; 15797531; 11959400; 10897644; 9808641; 16093404; 15831910; 9781393; 16871332; 10958818; 15990733; 9565830

# ChEBI_ID:
27470

# CAS_Registry_Number:
59-30-3

# InChI:
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

# Synthesis_Reference:
 Journal of Heterocyclic Chemistry  (1987),  24(1),  279-82.

# Melting_Point:
250 oC

# Melting_Point_predicted:
198.2 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.0016 mg/mL [MERCK INDEX (1983)]

# H2O_Solubility_Predicted:
0.0761 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.81 [MEYLAN,WM & HOWARD,PH (1995)]; -2.5 [Predicted by PubChem via XLOGP]; -0.04 [Predicted by ALOGPS]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Folic acid.pdf:::1132562202452413229

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::1176921976.mol:::146495287966197

# SDF_File_[Text]:
tbl_chemical:::HMDB00121.sdf:::119283199335199257

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00121.pdb:::119283199615762049

# PDB_ID:
1CD2

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041007_P00_03_HW_1DP_PRESAT_expanded_2.gif:::114460751395330648

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041007_P00_03_HW_1DP_presat.zip:::117771057213574272

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041007_P00_03_HW_1DP_Assigned.png:::114660302100083163

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041007_P00_03_HW_Presat_1DP.png:::116440013071864040

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041007_P00_03_HW_Presat_1DP.zip:::116440013076833373

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041007_P00_03_HW_2DHSQC_834.png:::115334752226923659

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041007_P00_03_HW_2DHSQC_834.zip:::114805892489439318

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041007_P00_03_HW_2DHSQC_834_Assigned.png:::116249835643042820

# Predicted_H_NMR_Spectrum:
tbl_chemical:::folic acid.gif:::1132732110593372819

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00121_peaks.txt:::1156309556515692705

# Predicted_C_NMR_Spectrum:
tbl_chemical:::folic acid_C.gif:::1132737689523342832

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00121_peaks.txt:::1156310746629736530

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP); Extracellular

# Tissue_Location:
Brain; Erythrocyte; Kidneys; Liver

# deuterated:
No

# Biofluid_Location:
Amniotic Fluid; Blood; CSF; Cellular Cytoplasm; Urine

# Concentration_[Normal]:
Urine	< 0.01	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	15321809
Blood	0.18 (0.10 - 0.35)	umol/L	Adult:>18_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 131. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	0.039 (0.01 - 0.14)	umol/L	Newborn:0-30_days_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 131. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	0.011 (0.004 - 0.028)	umol/L	Children:1-13_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 131. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	0.020 (0.005 - 0.061)	umol/L	Adult:>18_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 131. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	0.077 (0.071-0.083)	uM	Adult:>18_yrs_old	Both	Normal	16871332
Blood	0.011-0.036	uM	Adult:>18_yrs_old	Both	Normal	Tietz Clinical Guide to Laboratory Tests, 4th. Ed. 2006 Elsevier
Cerebrospinal_Fluid(CSF)	0.0078 +/- 0.0011	uM	Adult:>18_yrs_old	N/A	Normal	11959400
Cerebrospinal_Fluid(CSF)	0.053 +/- 0.024	N/A	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	0.006 +/- 0.0005 	uM	Elderly:>65_yrs_old	Both	Normal	11959400
Cellular_Cytoplasm	0.735 +/- 0.202	umol/L	Newborn:0-30_days_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 131. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Cellular_Cytoplasm	0.453 +/- 0.131	umol/L	Adult:>18_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 131. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Cellular_Cytoplasm	> 0.35	uM	Adult:>18_yrs_old	Both	Normal	Merck Manual


# Concentration_[Abnormal]:
Blood	< 0.007	uM	Adult:>18_yrs_old	Both	Folate Deficiency	Tietz Clinical Guide to Laboratory Tests, 4th. Ed. 2006 Elsevier
Cerebrospinal_Fluid(CSF)	0.008 +/- 0.0011 	uM	Elderly:>65_yrs_old	Both	Alzheimer’s disease	11959400
Cerebrospinal_Fluid(CSF)	0.0056 +/- 0.005	uM	Adult:>18_yrs_old	Both	Alzheimer's Disease	11959400


# Associated_Disorders:
Alzheimer's Disease; Alzheimer’s disease; Folate Deficiency; Hyperhomocysteinemia; Thrombophilia

# Pathway_Names:
Glycolysis

# Pathway_Images:
Glycolysis.jpg

# KEGG_Images:
map00010

# Pathway_Graphs:
Glycolysis_Graph.jpg

# Pathway_SBMLs:
Glycolysis.xml

# Metabolic_Enzyme_1_ID:
5504

# Metabolic_Enzyme_1_Name:
Catechol O-methyltransferase

# Metabolic_Enzyme_1_Synonyms:
Not Available

# Metabolic_Enzyme_1_Gene_Name:
COMT

# Metabolic_Enzyme_1_Protein_Sequence:
>Catechol Omethyltransferase
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRIL
NHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCG
YSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKY
DVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFE
CTHYQSFLEYREVVDGLEKAIYKGPGSEAGP

# Metabolic_Enzyme_1_Number_of_Residues:
271

# Metabolic_Enzyme_1_Molecular_Weight:
30037

# Metabolic_Enzyme_1_Theoretical_pI:
5.15

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  O-methyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol

# Metabolic_Enzyme_1_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_1_Reaction:
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01596:Methyltransf_3

# Metabolic_Enzyme_1_Signals:
1-32

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.1.1.6

# Metabolic_Enzyme_1_GenBank_ID_Protein:
180920

# Metabolic_Enzyme_1_SwissProt_ID:
COMT_HUMAN (P21964)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
COMT

# Metabolic_Enzyme_1_Geneatlas_id:
COMT

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2228

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Isoform S-COMT:Cytoplasm. Isoform MB-COMT:Cell membrane; single-pass type II membrane protein; extracellular side

# Metabolic_Enzyme_1_Gene_Sequence:
>816 bp
ATGCCGGAGGCCCCGCCTCTGCTGTTGGCAGCTGTGTTGCTGGGCCTGGTGCTGCTGGTG
GTGCTGCTGCTGCTTCTGAGGCACTGGGGCTGGGGCCTGTGCCTTATCGGCTGGAACGAG
TTCATCCTGCAGCCCATCCACAACCTGCTCATGGGTGACACCAAGGAGCAGCGCATCCTG
AACCACGTGCTGCAGCATGCGGAGCCCGGGAACGCACAGAGCGTGCTGGAGGCCATTGAC
ACCTACTGCGAGCAGAAGGAGTGGGCCATGAACGTGGGCGACAAGAAAGGCAAGATCGTG
GACGCCGTGATTCAGGAGCACCAGCCCTCCGTGCTGCTGGAGCTGGGGGCCTACTGTGGC
TACTCAGCTGTGCGCATGGCCCGCCTGCTGTCACCAGGGGCGAGGCTCATCACCATCGAG
ATCAACCCCGACTGTGCCGCCATCACCCAGCGGATGGTGGATTTCGCTGGCGTGAAGGAC
AAGGTCACCCTTGTGGTTGGAGCGTCCCAGGACATCATCCCCCAGCTGAAGAAGAAGTAT
GATGTGGACACACTGGACATGGTCTTCCTCGACCACTGGAAGGACCGGTACCTGCCGGAC
ACGCTTCTCTTGGAGGAATGTGGCCTGCTGCGGAAGGGGACAGTGCTACTGGCTGACAAC
GTGATCTGCCCAGGTGCGCCAGACTTCCTAGCACACGTGCGCGGGAGCAGCTGCTTTGAG
TGCACACACTACCAATCGTTCCTGGAATACAGGGAGGTGGTGGACGGCCTGGAGAAGGCC
ATCTACAAGGGCCCAGGCAGCGAAGCAGGGCCCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M65212

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_1_Locus:
22q11.21-q11.23|22q11.21

# Metabolic_Enzyme_1_SNPs:
rs5031015; rs6267; rs4680; rs13306279; rs13306281; rs6270; rs740602; rs8192488; rs4818; rs769223; rs769224; rs165631; rs4633; rs6269; rs739368; rs165656; rs4646312; rs5992501; rs7287550; rs165722; rs5746849; rs11569715; rs740603; rs9332380; rs7290221; rs174674; rs9332351; rs3810595; rs174675; rs5993887; rs9332361; rs6518593; rs174680; rs9332356; rs5993882; rs11569716; rs3087869; rs9332325; rs174673; rs174678; rs5993883; rs933271; rs9332359; rs165767; rs9332347; rs8185002; rs5993879; rs9332363; rs174691; rs9332332; rs5992500; rs174682; rs9332346; rs13306280; rs362204; rs174688; rs9332342; rs11569717; rs174695; rs5993881; rs7291003; rs1544325; rs9332331; rs3819621; rs174684; rs34798238; rs174677; rs174690; rs9606196; rs174693; rs11912353; rs12053782; rs11913025; rs36111598; rs5993888; rs9332362; rs174685; rs34438295; rs5992499; rs34691071; rs9332357; rs174692; rs9332334; rs3838146; rs9332333; rs9332352; rs35014456; rs35527466; rs35558779; rs11704299; rs9332350; rs6268; rs34450201; rs9680656; rs1055503; rs11912354; rs11089323; rs5993884; rs16982842; rs174679; rs9332353; rs34300220; rs9332358; rs9332360; rs34937293; rs34966851; rs174676; rs16982844; rs5844402; rs9332323; rs35919169; rs174683; rs35777291; rs9332348; rs8140865; rs34686565; rs165737; rs4646315; rs2239393; rs165774; rs9306235; rs740601; rs5993889; rs9306234; rs4646316; rs8140835; rs4646317; rs9332370; rs174697; rs174696; rs9332377; rs4646318; rs1109436; rs9332368; rs3218737; rs34068292; rs9332369; rs9332364; rs9332372; rs9332367; rs9332365; rs4646313; rs34446512; rs34819182; rs174699; rs34234839; rs165895; rs165599; rs9332381; rs35478083; rs36082074; rs11544670; rs4986871; rs11544669; rs165879; rs35791904; rs35788262; rs13054814; rs5992498; rs5748490; rs361698; rs28600912; rs9605040; rs11703339; rs9332319; rs174689; rs9606193; rs5844403; rs9332340; rs34778315; rs11703340; rs5993886; rs14968; rs9332344; rs28621910; rs3081743; rs174681; rs361549; rs35280052; rs361708; rs12167365; rs2004497; rs12170804; rs35357972; rs9332321; rs361574; rs9332328; rs35920235; rs9332337; rs5993880; rs12814; rs9332343; rs11544667; rs9606195; rs9332349; rs11296030; rs5748492; rs9332354; rs34029447; rs35188675; rs3819619; rs8136901; rs35094299; rs9332322; rs28804429; rs174687; rs9332339; rs11912495; rs35617967; rs9332327; rs9332336; rs3841769; rs12167215; rs362253; rs9332338; rs35689277; rs11703069; rs174686; rs12168881; rs9606194; rs361699; rs9332355; rs3081741; rs5746850; rs9617852; rs28565095; rs13306277; rs174698; rs9332373; rs9332374; rs9332366; rs13054356; rs35819339; rs11460758; rs4646314; rs34016976; rs2904564; rs12158230; rs13055002; rs9332375; rs28562050; rs9332378; rs9332371; rs9332376; rs10427781; rs10427983; rs10483103; rs1110477; rs1110478; rs1110479; rs12165997; rs12169508; rs12627876; rs165655; rs165728; rs165815; rs165824; rs165840; rs165849; rs1800749; rs2020917; rs2073749; rs2239394; rs2239395; rs2240713; rs2240714; rs2240715; rs2240718; rs2518823; rs2518824; rs2871047; rs34134422; rs35219372; rs3788319; rs3788320; rs4646310; rs5746846; rs5746847; rs5748483; rs5748484; rs5993890; rs5993891; rs7288060; rs737864; rs737865; rs737866; rs758373; rs8140265; rs887199; rs887200; rs9265; rs9332314; rs9332315; rs9605030; rs9605031; rs9606186; rs9606189; rs9606201; rs9618716

# Metabolic_Enzyme_1_General_References:
1707278; 1847521; 8055944; 1993083; 1765063; 8807664; 10391209

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5529

# Metabolic_Enzyme_2_Name:
Aldehyde dehydrogenase 1A3

# Metabolic_Enzyme_2_Synonyms:
Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3

# Metabolic_Enzyme_2_Gene_Name:
ALDH1A3

# Metabolic_Enzyme_2_Protein_Sequence:
>Aldehyde dehydrogenase 1A3
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI
CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM
DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW
NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV
GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE
CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK
QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL
KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF
KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP

# Metabolic_Enzyme_2_Number_of_Residues:
512

# Metabolic_Enzyme_2_Molecular_Weight:
56109

# Metabolic_Enzyme_2_Theoretical_pI:
7.29

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system

# Metabolic_Enzyme_2_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_2_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
544482

# Metabolic_Enzyme_2_SwissProt_ID:
AL1A3_HUMAN (P47895)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ALDH1A3

# Metabolic_Enzyme_2_Geneatlas_id:
ALDH1A3

# Metabolic_Enzyme_2_hgnc_id:
HGNC:409

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1539 bp
ATGGCCACCGCTAACGGGGCCGTGGAAAACGGGCAGCCGGACGGGAAGCCGCCGGCCCTG
CCGCGCCCCATCCGCAACCTGGAGGTCAAGTTCACCAAGATATTTATCAACAATGAATGG
CACGAATCCAAGAGTGGGAAAAAGTTTGCTACATGTAACCCTTCAACTCGGGAGCAAATA
TGTGAAGTGGAAGAAGGAGATAAGCCCGACGTGGACAAGGCTGTGGAGGCTGCACAGGTT
GCCTTCCAGAGGGGCTCGCCATGGCGCCGGCTGGATGCCCTGAGTCGTGGGCGGCTGCTG
CACCAGCTGGCTGACCTGGTGGAGAGGGACCGCGCCACCTTGGCCGCCCTGGAGACGATG
GATACAGGGAAGCCATTTCTTCATGCTTTTTTCATCGACCTGGAGGGCTGTATTAGAACC
CTCAGATACTTTGCAGGGTGGGCAGACAAAATCCAGGGCAAGACCATCCCCACAGATGAC
AACGTCGTATGCTTCACCAGGCATGAGCCCATTGGTGTCTGTGGGGCCATCACTCCATGG
AACTTCCCCCTGCTGATGCTGGTGTGGAAGCTGGCACCCGCCCTCTGCTGTGGGAACACC
ATGGTCCTGAAGCCTGCGGAGCAGACACCTCTCACCGCCCTTTATCTCGGCTCTCTGATC
AAAGAGGCCGGGTTCCCTCCAGGAGTGGTGAACATTGTGCCAGGATTCGGGCCCACAGTG
GGAGCAGCAATTTCTTCTCACCCTCAGATCAACAAGATCGCCTTCACCGGCTCCACAGAG
GTTGGAAAACTGGTTAAAGAAGCTGCGTCCCGGAGCAATCTGAAGCGGGTGACGCTGGAG
CTGGGGGGGAAGAACCCCTGCATCGTGTGTGCGGACGCTGACTTGGACTTGGCAGTGGAG
TGTGCCCATCAGGGAGTGTTCTTCAACCAAGGCCAGTGTTGCACGGCAGCCTCCAGGGTG
TTCGTGGAGGAGCAGGTCTACTCTGAGTTTGTCAGGCGGAGCGTGGAGTATGCCAAGAAA
CGGCCCGTGGGAGACCCCTTCGATGTCAAAACAGAACAGGGGCCTCAGATTGATCAAAAG
CAGTTCGACAAAATCTTAGAGCTGATCGAGAGTGGGAAGAAGGAAGGGGCCAAGCTGGAA
TGCGGGGGCTCAGCCATGGAAGACAAGGGGCTCTTCATCAAACCCACTGTCTTCTCAGAA
GTCACAGACAACATGCGGATTGCCAAAGAGGAGATTTTCGGGCCAGTGCAACCAATACTG
AAGTTCAAAAGTATCGAAGAAGTGATAAAAAGAGCGAATAGCACCGACTATGGACTCACA
GCAGCCGTGTTCACAAAAAATCTCGACAAAGCCCTGAAGTTGGCTTCTGCCTTAGAGTCT
GGAACGGTCTGGATCAACTGCTACAACGCCCTCTATGCACAGGCTCCATTTGGTGGCTTT
AAAATGTCAGGAAATGGCAGAGAACTAGGTGAATACGCTTTGGCCGAATACACAGAAGTG
AAAACTGTCACCATCAAACTTGGCGACAAGAACCCCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
U07919

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_2_Locus:
15q26.3

# Metabolic_Enzyme_2_SNPs:
rs3803430; rs2229183; rs1130738; rs14226; rs3803424; rs7045; rs3803426; rs7182089; rs4646690; rs7161860; rs4246328; rs4646688; rs4646668; rs4646670; rs3803428; rs4646671; rs6598396; rs4646675; rs9944290; rs7181897; rs4646684; rs4246323; rs4246327; rs4246329; rs4646674; rs8039374; rs4646678; rs4646653; rs4646655; rs7182884; rs3809521; rs11854028; rs3825926; rs3803433; rs6598397; rs4646662; rs4646685; rs4646651; rs4646672; rs3922685; rs4646654; rs3902902; rs4646683; rs7176046; rs3803432; rs4246324; rs4646661; rs8030776; rs12903828; rs4646687; rs4646680; rs3825925; rs7178221; rs3803427; rs7170197; rs4246325; rs8023972; rs4646681; rs7167278; rs4246326; rs1886; rs4646649; rs12908902; rs7171776; rs3803429; rs12914598; rs4646669; rs4646650; rs3803434; rs4646660; rs4646682; rs3809524; rs3809523; rs3809526; rs7179268; rs1130737; rs3803431; rs1130768; rs34302490; rs28760343; rs35300460; rs1802602; rs1802604; rs4288979; rs3803425; rs1802603; rs4646663; rs28691047; rs28731371; rs34655770; rs35165034; rs28509297; rs10400871; rs35129664; rs12905372; rs28405557; rs34486175; rs28546254; rs35055541; rs4646686; rs28441320; rs28410143; rs4646676; rs4646648; rs8029933; rs12910188; rs34182689; rs28504296; rs28449981; rs28507582; rs3825927; rs35310246; rs12910025; rs28384196; rs4343265; rs12910662; rs8028283; rs28475530; rs4392045; rs28369514; rs28377287; rs8035722; rs28480133; rs28707102; rs28583888; rs4646666; rs7173413; rs28472416; rs28673034; rs28668881; rs28711429; rs34837038; rs4646659; rs28452487; rs28712665; rs12910029; rs12902704; rs4646673; rs28689536; rs28431101; rs34431941; rs7178645; rs28454526; rs7170202; rs1889; rs4646647; rs4375646; rs11348272; rs4646656; rs28408085; rs28699556; rs28615197; rs28539744; rs28557216; rs28631565; rs34302839; rs3923499; rs4646664; rs35740226; rs28385499; rs3922686; rs28474807; rs28490217; rs12909825; rs10593974; rs28679806; rs28610999; rs7178553; rs35519561; rs35831758; rs35526807; rs4646658; rs28538652; rs28685242; rs10400842; rs4646667; rs35948146; rs4646677; rs7165217; rs10400872; rs28750207; rs3825924; rs7171453; rs34906846; rs4646665; rs9920154; rs36081993; rs11435500; rs28464660; rs4646679; rs12595234; rs4646689; rs3809522; rs35950557; rs3809527; rs7172149; rs7178931; rs8034153; rs7183889; rs3809525; rs4646646; rs11630601; rs11630691; rs11632820; rs11637204; rs11854709; rs12148466; rs12148493; rs12440023; rs12593839; rs12901792; rs12907776; rs12908105; rs12909230; rs12909791; rs28507591; rs3803435; rs4346184; rs4646694; rs7163108; rs7164136; rs7181644; rs8034686; rs8035036

# Metabolic_Enzyme_2_General_References:
7698756

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5810

# Metabolic_Enzyme_3_Name:
Aldehyde dehydrogenase 3B2

# Metabolic_Enzyme_3_Synonyms:
Aldehyde dehydrogenase 8

# Metabolic_Enzyme_3_Gene_Name:
ALDH3B2

# Metabolic_Enzyme_3_Protein_Sequence:
>Aldehyde dehydrogenase 3B2
MKDEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGNCVVLKPSE
ISQGTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAAT
KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLL
PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVL
VDVQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERT
SSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEI
RYPPYTDWNQQLLRWGMGSQSCTLL

# Metabolic_Enzyme_3_Number_of_Residues:
385

# Metabolic_Enzyme_3_Molecular_Weight:
42670

# Metabolic_Enzyme_3_Theoretical_pI:
5.97

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

# Metabolic_Enzyme_3_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_3_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1051281

# Metabolic_Enzyme_3_SwissProt_ID:
AL3B2_HUMAN (P48448)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ALDH3B2

# Metabolic_Enzyme_3_Geneatlas_id:
ALDH3B2

# Metabolic_Enzyme_3_hgnc_id:
HGNC:411

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>1158 bp
ATGAAGGATGAACCACGGTCCACGAACCTGTTCATGAAGCTGGACTCGGTCTTCATCTGG
AAGGAACCCTTTGGCCTGGTCCTCATCATCGCACCCTGGAACTACCCATTGAACCTGACC
CTGGTGCTCCTGGTGGGCACCCTCCCCGCAGGGAATTGCGTGGTGCTGAAGCCGTCAGAA
ATCAGCCAGGGCACAGAGAAGGTCCTGGCTGAGGTGCTGCCCCAGTACCTGGACCAGAGC
TGCTTTGCCGTGGTGCTGGGCGGACCCCAGGAGACAGGGCAGCTGCTAGAGCACAAGTTG
GACTACATCTTCTTCACAGGGAGCCCTCGTGTGGGCAAGATTGTCATGACTGCTGCCACC
AAGCACCTGACGCCTGTCACCCTGGAGCTGGGGGGCAAGAACCCCTGCTACGTGGACGAC
AACTGCGACCCCCAGACCGTGGCCAACCGCGTGGCCTGGTTCTGCTACTTCAATGCCGGC
CAGACCTGCGTGGCCCCTGACTACGTCCTGTGCAGCCCCGAGATGCAGGAGAGGCTGCTG
CCCGCCCTGCAGAGCACCATCACCCGTTTCTATGGCGACGACCCCCAGAGCTCCCCAAAC
CTGGGCCGCATCATCAACCAGAAACAGTTCCAGCGGCTGCGGGCATTGCTGGGCTGCGGC
CGCGTGGCCATTGGGGGCCAGAGCAACGAGAGCGATCGCTACATCGCCCCCACGGTGCTG
GTGGACGTGCAGGAGACGGAGCCTGTGATGCAGGAGGAGATCTTCGGGCCCATCCTGCCC
ATCGTGAACGTGCAGAGCGTGGACGAGGCCATCAAGTTCATCAACCGGCAGGAGAAGCCC
CTGGCCCTGTACGCCTTCTCCAACAGCAGACAGGTTGTGAACCAGATGCTGGAGCGGACC
AGCAGCGGCAGCTTTGGAGGCAATGAGGGCTTCACCTACATATCTCTGCTGTCCGTGCCA
TTCGGGGGAGTCGGCCACAGTGGGATGGGCCGGTACCACGGCAAGTTCACCTTCGACACC
TTCTCCCACCACCGCACCTGCCTGCTCGCCCCCTCCGGCCTGGAGAAATTAAAGGAGATC
CGCTACCCACCCTATACCGACTGGAACCAGCAGCTGTTACGCTGGGGCATGGGCTCCCAG
AGCTGCACCCTCCTGTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U37519

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_3_Locus:
11q13

# Metabolic_Enzyme_3_SNPs:
rs3741178; rs1551888; rs4646826; rs6591270; rs1551886; rs3741172; rs2279123; rs2279124; rs17510687; rs4313593; rs3127; rs1551885; rs3808972; rs2279125; rs1903829; rs866907; rs7947978; rs11823098; rs7114210; rs2514061; rs2251277; rs6591274; rs6591273; rs4646823; rs3825021; rs28372760; rs2279126; rs6591272; rs7947754; rs5019163; rs1871031; rs4930471; rs2514063; rs4569014; rs4930472; rs12295420; rs2251281; rs10791909; rs9787887; rs6591271; rs9736142; rs3741179; rs2514060; rs4930465; rs1551887; rs1871032; rs1979376; rs1979375; rs11603033; rs6591269; rs7934566; rs11821703; rs2514056; rs2514057; rs1140670; rs2447571; rs12292126; rs1131740; rs12278968; rs17856219; rs1051493; rs4646818; rs2514019; rs4587733; rs7483770; rs4646821; rs28887499; rs2447570; rs2514058; rs35431164; rs7944424; rs34589365; rs3191912; rs2514059; rs34763154; rs2514062; rs4930474; rs4646820; rs4581451; rs4646822; rs35843427; rs34926854; rs34057662; rs12361092; rs35632190; rs35691462; rs4646819; rs7483773; rs12288316; rs2447598; rs35605762; rs36154763; rs1131725; rs12272679; rs3928535; rs4930475; rs5019164; rs2447593; rs11227878; rs4646827; rs2126716; rs12285813; rs7943880; rs28819504; rs34264835; rs3741177; rs5792425; rs12807294; rs4244825; rs4646824; rs5792424; rs4646825; rs33990300; rs11826930; rs12574701; rs12294545; rs11824747; rs10736660; rs11828473; rs12272021; rs12288023; rs12363825; rs2054409; rs2447597; rs2509720; rs2514024; rs2514025; rs2885171; rs4930211; rs4930212; rs4930463; rs4930464; rs6591267; rs7108411

# Metabolic_Enzyme_3_General_References:
7484374; 8890755

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5527

# Metabolic_Enzyme_4_Name:
Aldehyde dehydrogenase, dimeric NADP-preferring

# Metabolic_Enzyme_4_Synonyms:
ALDH class 3; ALDHIII

# Metabolic_Enzyme_4_Gene_Name:
ALDH3A1

# Metabolic_Enzyme_4_Protein_Sequence:
>Aldehyde dehydrogenase, dimeric NADPpreferring
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH

# Metabolic_Enzyme_4_Number_of_Residues:
453

# Metabolic_Enzyme_4_Molecular_Weight:
50380

# Metabolic_Enzyme_4_Theoretical_pI:
6.52

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes

# Metabolic_Enzyme_4_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_4_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
178402

# Metabolic_Enzyme_4_SwissProt_ID:
AL3A1_HUMAN (P30838)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
ALDH3A1

# Metabolic_Enzyme_4_Geneatlas_id:
ALDH3A1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:405

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_4_Gene_Sequence:
>1362 bp
ATGAGCAAGATCAGCGAGGCCGTGAAGCGCGCCCGCGCCGCCTTCAGCTCGGGCAGGACC
CGTCCGCTGCAGTTCCGATTCCAGCAGCTGGAGGCGCTGCAGCGCCTGATCCAGGAGCAG
GAGCAGGAGCTGGTGGGCGCGCTGGCCGCAGACCTGCACAAGAATGAATGGAACGCCTAC
TATGAGGAGGTGGTGTACGTCCTAGAGGAGATCGAGTACATGATCCAGAAGCTCCCTGAG
TGGGCCGCGGATGAGCCCGTGGAGAAGACGCCCCAGACTCAGCAGGACGAGCTCTACATC
CACTCGGAGCCACTGGGCGTGGTCCTCGTCATTGGCACCTGGAACTACCCCTTCAACCTC
ACCATCCAGCCCATGGTGGGCGCCATCGCTGCAGGGAACGCAGTGGTCCTCAAGCCCTCG
GAGCTGAGTGAGAACATGGCGAGCCTGCTGGCTACCATCATCCCCCAGTACCTGGACAAG
GATCTGTACCCAGTAATCAATGGGGGTGTCCCTGAGACCACGGAGCTGCTCAAGGAGAGG
TTCGACCATATCCTGTACACGGGCAGCACGGGGGTGGGGAAGATCATCATGACGGCTGCT
GCCAAGCACCTGACCCCTGTCACGCTGGAGCTGGGAGGGAAGAGTCCCTGCTACGTGGAC
AAGAACTGTGACCTGGACGTGGCCTGCCGACGCATCGCCTGGGGGAAATTCATGAACAGT
GGCCAGACCTGCGTGGCCCCAGACTACATCCTCTGTGACCCCTCGATCCAGAACCAAATT
GTGGAGAAGCTCAAGAAGTCACTGAAAGAGTTCTACGGGGAAGATGCTAAGAAATCCCGG
GACTATGGAAGAATCATTAGTGCCCGGCACTTCCAGAGGGTGATGGGCCTGATTGAGGGC
CAGAAGGTGGCTTATGGGGGCACCGGGGATGCCGCCACTCGCTACATAGCCCCCACCATC
CTCACGGACGTGGACCCCCAGTCCCCGGTGATGCAAGAGGAGATCTTCGGGCCTGTGCTG
CCCATCGTGTGCGTGCGCAGCCTGGAGGAGGCCATCCAGTTCATCAACCAGCGTGAGAAG
CCCCTGGCCCTCTACATGTTCTCCAGCAACGACAAGGTGATTAAGAAGATGATTGCAGAG
ACATCCAGTGGTGGGGTGGCGGCCAACGATGTCATCGTCCACATCACCTTGCACTCTCTG
CCCTTCGGGGGCGTGGGGAACAGCGGCATGGGATCCTACCATGGCAAGAAGAGCTTCGAG
ACTTTCTCTCACCGCCGCTCTTGCCTGGTGAGGCCTCTGATGAATGATGAAGGCCTGAAG
GTCAGATACCCCCCGAGCCCGGCCAAGATGACCCAGCACTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M74542

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_4_Locus:
17p11.2

# Metabolic_Enzyme_4_SNPs:
rs887241; rs2228100; rs3744692; rs2072330; rs4646787; rs1042183; rs917520; rs4646789; rs4646788; rs3786036; rs887240; rs2072329; rs4646790; rs3744693; rs9895030; rs3826507; rs3744695; rs3744694; rs2072328; rs1006556; rs4319825; rs1042172; rs11554977; rs11554978; rs11554975; rs11554974; rs34474118; rs3786037; rs35473971; rs4646792; rs35116940; rs4646791; rs35853488; rs887239; rs28531080; rs7216299; rs35009373; rs3786035; rs11385990; rs35308039; rs35128135; rs35885485; rs28552545; rs34438543; rs1006553; rs11650088; rs11651480; rs11870332; rs12948881; rs12949049; rs12951039; rs16960382; rs16960386; rs17793620; rs1989379; rs2016823; rs2052052; rs2072327; rs2108967; rs3760485; rs3760486; rs3760487; rs4646783; rs4646784; rs4646785; rs4646786; rs4924793; rs4925046; rs7214841; rs7221211; rs7225305; rs8075157; rs9898715; rs9900430

# Metabolic_Enzyme_4_General_References:
1737758; 8493892; 2037078; 9250352

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5811

# Metabolic_Enzyme_5_Name:
Aldehyde dehydrogenase 3B1

# Metabolic_Enzyme_5_Synonyms:
Aldehyde dehydrogenase 7

# Metabolic_Enzyme_5_Gene_Name:
ALDH3B1

# Metabolic_Enzyme_5_Protein_Sequence:
>Aldehyde dehydrogenase 3B1
MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE
VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL
TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR
FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA
GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC
GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK
PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD
TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL

# Metabolic_Enzyme_5_Number_of_Residues:
468

# Metabolic_Enzyme_5_Molecular_Weight:
51840

# Metabolic_Enzyme_5_Theoretical_pI:
7.67

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_5_Specific_Function:
An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

# Metabolic_Enzyme_5_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_5_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_5_GenBank_ID_Protein:
601780

# Metabolic_Enzyme_5_SwissProt_ID:
AL3B1_HUMAN (P43353)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ALDH3B1

# Metabolic_Enzyme_5_Geneatlas_id:
ALDH3B1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:410

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Not Available

# Metabolic_Enzyme_5_Gene_Sequence:
>1407 bp
ATGGACCCCCTTGGGGACACGCTGCGGCGACTGCGGGAGGCCTTCCACGCGGGGCGCACG
CGGCCAGCTGAGTTCCGGGCTGCGCAGCTCCAAGGCCTGGGCCGCTTCCTGCAAGAAAAC
AAGCAGCTTCTGCACGACGCACTGGCCCAGGACCTGCACAAGTCAGCCTTCGAGTCGGAG
GTGTCTGAGGTTGCCATCAGCCAGGGCGAGGTCACCCTGGCCCTCAGGAACCTCCGGGCC
TGGATGAAGGACGAGCGTGTGCCCAAGAACCTGGCCACGCAGCTGGACTCCGCCTTCATC
CGGAAGGAGCCCTTTGGCCTGGTCCTCATCATTGCGCCCTGGAACTATCCGCTGAACCTG
ACGCTGGTGCCCCTCGTGGGAGCCCTCGCTGCAGGGAACTGTGTGGTGCTGAAGCCATCG
GAGATTAGCAAGAACGTCGAGAAGATCCTGGCCGAGGTGCTGCCCCAATACGTGGACCAG
AGCTGCTTTGCTGTGGTGCTGGGCGGGCCCCAGGAGACGGGGCAGCTGCTAGAGCACAGG
TTCGACTACATCTTCTTCACAGGGAGCCCTCGTGTGGGCAAGATTGTTATGACTGCTGCC
GCCAAGCACCTGACACCTGTCACCCTGGAGCTGGGGGGCAAGAACCCTTGCTACGTGGAC
GACAACTGCGACCCCCAGACCGTGGCCAACCGCGTGGCCTGGTTCCGCTACTTCAACGCC
GGCCAGACCTGCGTGGCCCCCGACTACGTCCTATGCAGCCCTGAGATGCAGGAGAGGCTG
CTGCCTGCCCTGCAGAGCACCATCACCCGTTTCTATGGCGACGACCCCCAGAGCTCCCCA
AACCTGGGCCGCATCATCAACCAGAAACAGTTCCAGCGGCTGCGGGCATTGCTGGGCTGC
GGCCGTGTGGCCATTGGGGGCCAGAGCGATGAGAGCGATCGCTACATCGCCCCCACGGTG
CTGGTGGATGTGCAGGAGATGGAGCCTGTGATGCAGGAGGAGATCTTCGGGCCCATCCTG
CCCATCGTGAACGTGCAGAGCTTGGACGAGGCCATCGAGTTCATCAACCGGCGGGAGAAG
CCCCTGGCCCTGTACGCCTTCTCCAACAGCAGCCAGGTGGTCAAGCGGGTGCTGACCCAG
ACCAGCAGCGGGGGCTTCTGTGGGAACGACGGCTTCATGCACATGACCCTGGCCAGCCTG
CCTTTTGGAGGAGTGGGTGCCAGTGGGATGGGCCGGTACCATGGCAAGTTCTCCTTCGAC
ACCTTCTCCCACCATCGCGCCTGCCTCCTGCGCAGCCCGGGGATGGAGAAGCTCAACGCC
CTCCGCTACCCGCCGCAATCGCCGCGCCGCCTGAGGATGCTGCTGGTGGCCATGGAGGCC
CAAGGCTGCAGCTGCACACTGCTCTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U10868

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_5_Locus:
11q13

# Metabolic_Enzyme_5_SNPs:
rs572574; rs3764821; rs172620; rs3794181; rs3751081; rs12281209; rs1703440; rs3764818; rs556601; rs2286170; rs1003777; rs308293; rs2286169; rs4646809; rs3764819; rs886702; rs2286163; rs2286164; rs3794177; rs2286165; rs105147; rs2286168; rs2286166; rs308342; rs7125916; rs2286171; rs3794176; rs581105; rs12574760; rs3751082; rs308341; rs34280013; rs475325; rs3764817; rs3751084; rs4244839; rs4646812; rs598156; rs3764816; rs1636207; rs886701; rs11228121; rs308336; rs2010404; rs308335; rs557098; rs308334; rs308338; rs308337; rs3763941; rs737265; rs308333; rs35738719; rs12794336; rs34580830; rs11607185; rs1636208; rs1793238; rs1636209; rs11605214; rs7108283; rs3815220; rs12286110; rs34494820; rs35406834; rs2286167; rs12789057; rs33945294; rs7116695; rs35785905; rs11436139; rs28584816; rs12799330; rs4646808; rs5792429; rs4646813; rs12284146; rs12806003; rs4646811; rs34109111; rs35256233; rs34526809; rs12277180; rs4646810; rs177812; rs34271562; rs8181582; rs11433668; rs7925460; rs34588975; rs34721102; rs7116941; rs3794179; rs12273237; rs34130972; rs5792428; rs7113328; rs34928150; rs7117605; rs35400021; rs11826595; rs1051806; rs1076558; rs10896288; rs1122731; rs11228120; rs11228122; rs11823975; rs11824781; rs11825872; rs12418774; rs12421254; rs12803743; rs1703438; rs1804688; rs191064; rs191065; rs2075626; rs2286172; rs28939679; rs308326; rs308339; rs308340; rs3115545; rs3115546; rs3115548; rs3133266; rs3133267; rs3133269; rs3751085; rs3763942; rs3808969; rs3808970; rs3808971; rs4147776; rs4147777; rs4147778; rs4147780; rs4147782; rs479763; rs7949541; rs7951010; rs7952122; rs884826; rs999571

# Metabolic_Enzyme_5_General_References:
7828891

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5316

# Metabolic_Enzyme_6_Name:
Thymidylate synthase

# Metabolic_Enzyme_6_Synonyms:
TS; TSase

# Metabolic_Enzyme_6_Gene_Name:
TYMS

# Metabolic_Enzyme_6_Protein_Sequence:
>Thymidylate synthase
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDE
FPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLD
SLGFSTREEGDLGPVYGFQWR
HFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRII
MCAWNPRDLPLMALPPCHALCQFYVVNSELSC
QLYQRSGDMGLGVPFNIASYALLTYMI
AHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLR
ILRKVEKIDDFKAEDF
QIEGYNPHPTIKMEMAV

# Metabolic_Enzyme_6_Number_of_Residues:
313

# Metabolic_Enzyme_6_Molecular_Weight:
35716

# Metabolic_Enzyme_6_Theoretical_pI:
7.00

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  5,10-methylenetetrahydrofolate-dependent methyltransferase activity
Function:  thymidylate synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  pyrimidine nucleotide metabolism
Process:  pyrimidine nucleotide biosynthesis
Process:  pyrimidine nucleoside monophosphate biosynthesis
Process:  pyrimidine deoxyribonucleoside monophosphate biosynthesis
Process:  dTMP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP

# Metabolic_Enzyme_6_Pathway:
map00240  Pyrimidine metabolism;
 map00670  One carbon pool by folate

# Metabolic_Enzyme_6_Reaction:
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00303:Thymidylat_synt

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.1.1.45

# Metabolic_Enzyme_6_GenBank_ID_Protein:
37479

# Metabolic_Enzyme_6_SwissProt_ID:
TYSY_HUMAN (P04818)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
TYMS

# Metabolic_Enzyme_6_Geneatlas_id:
TYMS

# Metabolic_Enzyme_6_hgnc_id:
HGNC:12441

# Metabolic_Enzyme_6_PDB_ID:
1JUJ

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>942 bp

ATGCCTGTGGCCGGCTCGGAGCTGCCGCGCCGGCCCTTGCCCCCCGCCGCACAGGAGCG
GGACGCCGAGC
CGCGTCCGCCGCACGGGGAGCTGCAGTACCTGGGGCAGATCCAACACA
TCCTCCGCTGCGGCGTCAGGAA
GGACGACCGCACGGGCACCGGCACCCTGTCGGTATTC
GGCATGCAGGCGCGCTACAGCCTGAGAGATGAA
TTCCCTCTGCTGACAACCAAACGTGT
GTTCTGGAAGGGTGTTTTGGAGGAGTTGCTGTGGTTTATCAAGG
GATCCACAAATGCTA
AAGAGCTGTCTTCCAAGGGAGTGAAAATCTGGGATGCCAATGGATCCCGAGACTT
TTTG
GACAGCCTGGGATTCTCCACCAGAGAAGAAGGGGACTTGGGCCCAGTTTATGGCTTCCAG
TGGAGG
CATTTTGGGGCAGAATACAGAGATATGGAATCAGATTATTCAGGACAGGGAGT
TGACCAACTGCAAAGAG
TGATTGACACCATCAAAACCAACCCTGACGACAGAAGAATCA
TCATGTGCGCTTGGAATCCAAGAGATCT
TCCTCTGATGGCGCTGCCTCCATGCCATGCC
CTCTGCCAGTTCTATGTGGTGAACAGTGAGCTGTCCTGC
CAGCTGTACCAGAGATCGGG
AGACATGGGCCTCGGTGTGCCTTTCAACATCGCCAGCTACGCCCTGCTCA
CGTACATGA
TTGCGCACATCACGGGCCTGAAGCCAGGTGACTTTATACACACTTTGGGAGATGCACATA
T
TTACCTGAATCACATCGAGCCACTGAAAATTCAGCTTCAGCGAGAACCCAGACCTTTC
CCAAAGCTCAGG
ATTCTTCGAAAAGTTGAGAAAATTGATGACTTCAAAGCTGAAGACTT
TCAGATTGAAGGGTACAATCCGC
ATCCAACTATTAAAATGGAAATGGCTGTTTAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
X02308

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:18

# Metabolic_Enzyme_6_Locus:
18p11.32

# Metabolic_Enzyme_6_SNPs:
rs3786362; rs16948421; rs699517; rs16948409; rs2790; rs2612098; rs2853740; rs2612100; rs1001761; rs2847149; rs2853532; rs2853536; rs2244500; rs2612099; rs2853543; rs11873890; rs1004474; rs2612096; rs1059394; rs16948305; rs9953447; rs2847609; rs2847150; rs1051527; rs8088781; rs2612095; rs1059393; rs3826626; rs15872; rs2853524; rs2853537; rs16948322; rs34795969; rs2847151; rs1970763; rs2853528; rs2853535; rs2606245; rs2853525; rs2853534; rs2847153; rs35143366; rs11876369; rs2853526; rs8094124; rs35069638; rs2925470; rs2015944; rs2853527; rs36005458; rs35517586; rs35449827; rs35710611; rs36080427; rs34502878; rs34007153; rs523998; rs11540152; rs596909; rs11540153; rs2847608; rs34543484; rs287599; rs571276; rs188267; rs1134333; rs2853531; rs11872109; rs172296; rs2853540; rs2853541; rs34118802; rs11875638; rs287600; rs2124616; rs2853530; rs11872105; rs35087169; rs9675762; rs1134338; rs12958458; rs11875614; rs2853739; rs35914751; rs287601; rs1894234; rs35626549; rs2853538; rs1894233; rs12962403; rs287602; rs1672564; rs1134335; rs35338895; rs2606244; rs8093444; rs2847610; rs35723992; rs207950; rs11878085; rs36009852; rs2853529; rs28503425; rs12326481; rs34581442; rs207949; rs571377; rs8084452; rs35623440; rs34941278; rs1672569; rs2606243; rs2606242; rs644072; rs2926562; rs2847611; rs11874511; rs11411741; rs11875662; rs10502289; rs10502290; rs1058151; rs1059384; rs11081251; rs11081266; rs11664283; rs11873007; rs11876755; rs11877806; rs12373391; rs12964837; rs2276115; rs2298581; rs2298582; rs2298583; rs2606241; rs2606246; rs2612092; rs2741182; rs2741183; rs2741184; rs2741186; rs2847173; rs2847324; rs2847326; rs2847607; rs2847612; rs2847620; rs2853533; rs2853741; rs2853742; rs3198762; rs34445332; rs35173059; rs3744962; rs3786355; rs3819101; rs3819102; rs495139; rs502396; rs539913; rs548203; rs579099; rs686819; rs7229142; rs7239738; rs8089075; rs8423; rs9948583; rs9966612

# Metabolic_Enzyme_6_General_References:
2987839; 2243092; 2532645; 3839505; 2656695; 8845352; 11329255; 11278511

# Metabolic_Enzyme_6_References:
16142999; 16284371; 17023046

# Metabolic_Enzyme_7_ID:
6211

# Metabolic_Enzyme_7_Name:
C-1-tetrahydrofolate synthase, cytoplasmic

# Metabolic_Enzyme_7_Synonyms:
C1-THF synthase[Includes: Methylenetetrahydrofolate dehydrogenase

# Metabolic_Enzyme_7_Gene_Name:
MTHFD1

# Metabolic_Enzyme_7_Protein_Sequence:
>C1tetrahydrofolate synthase, cytoplasmic
MAPAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAA
EEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAP
EKDVDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAP
MHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINY
VPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKP
GKWMIQYNNLNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSAL
ERLKHRPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGI
KGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLV
PSVNGVRRFSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRF
LRKITIGQAPTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPV
SAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVG
PEGFVVTEAGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLP
KAYIQENLELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAF
DAVKCTHWAEGGKGALALAQAVQRAAQAPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIE
LLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFL
YPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF

# Metabolic_Enzyme_7_Number_of_Residues:
935

# Metabolic_Enzyme_7_Molecular_Weight:
101561

# Metabolic_Enzyme_7_Theoretical_pI:
7.32

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  formate-tetrahydrofolate ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  aromatic compound metabolism
Process:  folic acid and derivative metabolism
Process:  folic acid and derivative biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH

# Metabolic_Enzyme_7_Pathway:
map00630  Glyoxylate and dicarboxylate metabolism;
 map00670  One carbon pool by folate

# Metabolic_Enzyme_7_Reaction:
ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF01268:FTHFS;
PF00763:THF_DHG_CYH;
PF02882:THF_DHG_CYH_C

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.5.1.5;EC 3.5.4.9;EC

# Metabolic_Enzyme_7_GenBank_ID_Protein:
307178

# Metabolic_Enzyme_7_SwissProt_ID:
C1TC_HUMAN (P11586)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
MTHFD1

# Metabolic_Enzyme_7_Geneatlas_id:
MTHFD1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:7432

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_7_Gene_Sequence:
>2808 bp
ATGGCGCCAGCAGAAATCCTGAACGGGAAGGAGATCTCCGCGCAAATAAGGGCGAGACTG
AAAAATCAAGTCACTCAGTTGAAGGAGCAAGTACCTGGTTTCACACCACGCCTGGCAATA
TTACAGGTTGGCAACAGAGATGATTCCAATCTTTATATAAATGTGAAGCTGAAGGCTGCT
GAAGAGATTGGGATCAAAGCCACTCACATTAAGTTACCAAGAACAACCACAGAATCTGAG
GTGATGAAGTACATTACATCTTTGAATGAAGACTCTACTGTACATGGGTTCTTAGTGCAG
CTACCTTTAGATTCAGAGAATTCCATTAACACTGAAGAAGTGATCAATGCTATTGCACCC
GAGAAGGATGTGGATGGATTGACTAGCATCAATGCTGGGAGACTTGCTAGAGGTGACCTC
AATGACTGTTTCATTCCTTGTACGCCTAAGGGATGCTTGGAACTCATCAAAGAGACAGGG
GTGCCGATTGCCGGAAGGCATGCTGTGGTGGTTGGGCGCAGTAAAATAGTTGGGGCCCCG
ATGCATGACTTGCTTCTGTGGAACAATGCCACAGTGACCACCTGCCACTCCAAGACTGCC
CATCTGGATGAGGAGGTAAATAAAGGTGACATCCTGGTGGTTGCAACTGGTCAGCCTGAA
ATGGTTAAAGGGGAGTGGATCAAACCTGGGGCAATAGTCATCGACTGTGGAATCAATTAT
GTCCCAGATGATAAAAAACCAAATGGGAGAAAAGTTGTGGGTGATGTGGCATACGACGAG
GCCAAAGAGAGGGCGAGCTTCATCACTCCTGTTCCTGGCGGCGTAGGGCCCATGACAGTT
GCAATGCTCATGCAGAGCACAGTAGAGAGTGCCAAGCGTTTCCTGGAGAAATTTAAGCCA
GGAAAGTGGATGATTCAGTATAACAACCTTAACCTCAAGACACCTGTTCCAAGTGACATT
GATATATCACGATCTTGTAAACCGAAGCCCATTGGTAAGCTGGCTCGAGAAATTGGTCTG
CTGTCTGAAGAGGTAGAATTATATGGTGAAACAAAGGCCAAAGTTCTGCTGTCAGCACTA
GAACGCCTGAAGCACCGGCCTGATGGGAAATACGTGGTGGTGACTGGAATAACTCCAACA
CCCCTGGGAGAAGGGAAAAGCACAACTACAATCGGGCTAGTGCAAGCCCTTGGTGCCCAT
CTCTACCAGAATGTCTTTGCGTGTGTGCGACAGCCTTCTCAGGGCCCCACCTTTGGAATA
AAAGGTGGCGCTGCAGGAGGCGGCTACTCCCAGGTCATTCCTATGGAAGAGTTTAATCTC
CACCTCACAGGTGACATCCATGCCATCACTGCAGCTAATAACCTCGTTGCTGCGGCCATT
GATGCTCGGATATTTCATGAACTGACCCAGACAGACAAGGCTCTCTTTAATCGTTTGGTG
CCATCAGTAAATGGAGTGAGAAGGTTCTCTGACATCCAAATCCGAAGGTTAAAGAGACTA
GGCATTGAAAAGACTGACCCTACCACACTGACAGATGAAGAGATAAACAGATTTGCAAGA
TTGGACATTGATCCAGAAACCATAACTTGGCAAAGAGTGTTGGATACCAATGATAGATTC
CTGAGGAAGATCACGATTGGACAGGCTCCAACGGAGAAGGGTCACACACGGACGGCCCAG
TTTGATATCTCTGTGGCCAGTGAAATTATGGCTGTCCTGGCTCTCACCACTTCTCTAGAA
GACATGAGAGAGAGACTGGGCAAAATGGTGGTGGCATCCAGTAAGAAAGGAGAGCCCGTC
AGTGCCGAAGATCTGGGGGTGAGTGGTGCACTGACAGTGCTTATGAAGGACGCAATCAAG
CCCAATCTCATGCAGACACTGGAGGGCACTCCAGTGTTTGTCCATGCTGGCCCGTTTGCC
AACATCGCACATGGCAATTCCTCCATCATTGCAGACCGGATCGCACTCAAGCTTGTTGGC
CCAGAAGGGTTTGTAGTGACGGAAGCAGGATTTGGAGCAGACATTGGAATGGAAAAGTTT
TTTAACATCAAATGCCGGTATTCCGGCCTCTGCCCCCACGTGGTGGTGCTTGTTGCCACT
GTCAGGGCTCTCAAGATGCACGGGGGCGGCCCCACGGTCACTGCTGGACTGCCTCTTCCC
AAGGCTTACATACAGGAGAACCTGGAGCTGGTTGAAAAAGGCTTCAGTAACTTGAAGAAA
CAAATTGAAAATGCCAGAATGTTTGGAATTCCAGTAGTAGTGGCCGTGAATGCATTCAAG
ACGGATACAGAGTCTGAGCTGGACCTCATCAGCCGCCTTTCCAGAGAACATGGGGCTTTT
GATGCCGTGAAGTGCACTCACTGGGCAGAAGGGGGCAAGGGTGCCTTAGCCCTGGCTCAG
GCCGTCCAGAGAGCAGCACAAGCACCCAGCAGCTTCCAGCTCCTTTATGACCTCAAGCTC
CCAGTTGAGGATAAAATCAGGATCATTGCACAGAAGATCTATGGAGCAGATGACATTGAA
TTACTTCCCGAAGCTCAACACAAAGCTGAAGTCTACACGAAGCAGGGCTTTGGGAATCTC
CCCATCTGCATGGCTAAAACACACTTGTCTTTGTCTCACAACCCAGAGCAAAAAGGTGTC
CCTACAGGCTTCATTCTGCCCATTCGCGACATCCGCGCCAGCGTTGGGGCTGGTTTTCTG
TACCCCTTAGTAGGAACGATGAGCACAATGCCTGGACTCCCCACCCGGCCCTGTTTTTAT
GATATTGATTTGGACCCTGAAACAGAACAGGTGAATGGATTATTCTAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
J04031

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_7_Locus:
14q24

# Metabolic_Enzyme_7_SNPs:
rs1950902; rs2236225; rs10137921; rs4902283; rs2281603; rs11627387; rs1885031; rs11158539; rs8012229; rs3783731; rs1256143; rs1956546; rs7151163; rs11629135; rs2295640; rs3783726; rs4899135; rs3818239; rs2295639; rs10133855; rs1256142; rs3783728; rs2236224; rs17101854; rs11622591; rs17824591; rs8003379; rs1256144; rs8003567; rs12434608; rs10135928; rs6573558; rs11849530; rs8011839; rs8016556; rs11158537; rs12434779; rs4902278; rs11158538; rs10149005; rs11627525; rs10498514; rs6573559; rs4902279; rs2093209; rs11158540; rs10142442; rs2295638; rs11844750; rs8019215; rs2884243; rs4902282; rs3818240; rs8003368; rs2236223; rs8006686; rs3825648; rs8015278; rs17751556; rs1256140; rs3783725; rs1256146; rs8016118; rs8020276; rs12587229; rs8022867; rs3742612; rs2357694; rs11627122; rs3742613; rs11622534; rs8022537; rs11621442; rs2236222; rs8013633; rs8023159; rs11848935; rs9671542; rs4902284; rs3783727; rs8017233; rs17101851; rs1256145; rs1803951; rs34181110; rs17857382; rs1803950; rs11551058; rs3215668; rs1801340; rs1803948; rs1803949; rs34559242; rs34619335; rs12895665; rs11390271; rs34046793; rs35834354; rs34166790; rs12896912; rs11624316; rs12888491; rs8015897; rs2145439; rs28449701; rs34280342; rs34737278; rs9783612; rs34457841; rs35749741; rs28655371; rs3062425; rs3825647; rs12147679; rs35786511; rs10678665; rs4902280; rs2295641; rs34982267; rs10138064; rs34498014; rs8018342; rs35315024; rs35313218; rs10524943; rs34415604; rs12897898; rs7492835; rs10138837; rs33944198; rs8019804; rs2104049; rs8022545; rs12895204; rs10146031; rs10719061; rs35399290; rs11364516; rs2357696; rs35960360; rs35360695; rs12896911; rs10582985; rs34179108; rs1885032; rs28628790; rs10142472; rs34177532; rs4902281; rs8018015; rs35789478; rs33997830; rs11629354; rs12591015; rs8015898; rs4899134; rs7144437; rs12892306; rs8004960; rs3842326; rs3825646; rs34736680; rs34456417; rs1256141; rs34596029; rs12591011; rs2884244; rs11628396; rs4899136; rs2295637; rs11849167; rs10144786; rs11628440; rs11628372; rs11324178; rs12432825; rs10628197; rs35984208; rs34380833; rs34399909; rs35327320; rs28630894; rs35192725; rs34804199; rs10150708; rs35280360; rs35284720; rs2357695; rs35927010; rs34110441; rs34004524; rs34013579; rs8013134; rs34868771; rs12147184; rs10587324; rs7147830; rs28716830; rs8020786; rs11444190; rs11628466; rs8020827; rs35945963; rs35725762; rs34931433; rs12880360; rs35957489; rs34158471; rs7145462; rs10547684; rs12886138; rs10140284; rs11289659; rs35824559; rs34735594; rs35307627; rs1076991; rs11158542; rs1256148; rs1256149; rs1956545; rs2230490; rs2230491; rs2230492; rs2357482; rs2983733; rs2983736; rs2983737; rs2983740; rs3020448; rs34433837; rs34616731; rs35020344; rs3742609; rs3783732; rs3783733; rs4902277; rs745686; rs746488

# Metabolic_Enzyme_7_General_References:
3053686; 12665801; 9519408; 9611072

# Metabolic_Enzyme_7_References:
16315005

# Metabolic_Enzyme_8_ID:
6074

# Metabolic_Enzyme_8_Name:
Serine hydroxymethyltransferase, cytosolic

# Metabolic_Enzyme_8_Synonyms:
Serine methylase; Glycine hydroxymethyltransferase; SHMT

# Metabolic_Enzyme_8_Gene_Name:
SHMT1

# Metabolic_Enzyme_8_Protein_Sequence:
>Serine hydroxymethyltransferase, cytosolic
MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA
VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG
SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV
VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL
QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL
VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK
VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL
PDF

# Metabolic_Enzyme_8_Number_of_Residues:
483

# Metabolic_Enzyme_8_Molecular_Weight:
53083

# Metabolic_Enzyme_8_Theoretical_pI:
7.77

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  glycine hydroxymethyltransferase activity
 ||
>>>
Process:  L-serine metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Interconversion of serine and glycine

# Metabolic_Enzyme_8_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00310  Lysine degradation;
 map00460  Cyanoamino acid metabolism;
 map00670  One carbon pool by folate;
 map00680  Methane metabolism

# Metabolic_Enzyme_8_Reaction:
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00464:SHMT

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.1.2.1

# Metabolic_Enzyme_8_GenBank_ID_Protein:
307422

# Metabolic_Enzyme_8_SwissProt_ID:
GLYC_HUMAN (P34896)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
SHMT1

# Metabolic_Enzyme_8_Geneatlas_id:
SHMT1

# Metabolic_Enzyme_8_hgnc_id:
HGNC:10850

# Metabolic_Enzyme_8_PDB_ID:
1BJ4

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_8_Gene_Sequence:
>1452 bp
ATGACGATGCCAGTCAACGGGGCCCACAAGGATGCTGACCTGTGGTCCTCACATGACAAG
ATGCTGGCACAACCCCTCAAAGACAGTGATGTTGAGGTTTACAACATCATTAAGAAGGAG
AGTAACCGGCAGAGGGTTGGATTGGAGCTGATTGCCTCGGAGAATTTCGCCAGCCGAGCA
GTTTTGGAGGCCCTAGGCTCTTGCTTAAATAACAAATACTCTGAGGGGTACCCGGGCCAG
AGATACTATGGCGGGACTGAGTTTATTGATGAACTGGAGACCCTCTGTCAGAAGCGAGCC
CTGCAGGCCTATAAGCTGGACCCACAGTGCTGGGGGGTCAACGTCCAGCCCTACTCAGGC
TCCCCTGCAAACTTTGCTGTGTACACTGCCCTGGTGGAACCCCATGGGCGCATCATGGGC
CTGGACCTTCCGGATGGGGGCCACCTGACCCATGGGTTCATGACAGACAAGAAGAAAATC
TCTGCCACGTCCATCTTCTTTGAATCTATGCCCTACAAGGTGAACCCAGATACTGGCTAC
ATCAACTATGACCAGCTGGAGGAGAACGCACGCCTCTTCCACCCGAAGCTGATCATCGCA
GGAACCAGCTGCTACTCCCGAAACCTGGAATATGCCCGGCTACGGAAGATTGCAGATGAG
AACGGGGCGTATCTCATGGCGGACATGGCTCACATCAGCGGGCTGGTGGCGGCTGGCGTG
GTGCCCTCCCCATTTGAACACTGCCATGTGGTGACCACCACCACTCACAAGACCCTGCGA
GGCTGCCGAGCTGGCATGATCTTCTACAGGAAAGGAGTGAAAAGTGTGGATCCCAAGACT
GGCAAAGAGATTCTGTACAACCTGGAGTCTCTTATCAATTCTGCTGTGTTCCCTGGCCTG
CAGGGAGGTCCCCACAACCACGCCATTGCTGGGGTTGCTGTGGCACTGAAGCAAGCTATG
ACTCTGGAATTTAAAGTTTATCAACACCAGGTGGTGGCCAACTGCAGGGCTCTGTCTGAG
GCCCTGACGGAGCTGGGCTACAAAATAGTCACAGGTGGTTCTGACAACCATTTGATCCTT
GTGGATCTCCGTTCCAAAGGCACAGATGGTGGAAGGGCTGAGAAGGTGCTAGAAGCCTGT
TCTATTGCCTGCAACAAGAACACCTGTCCAGGTGACAGAAGCGCTCTGCGGCCCAGTGGA
CTGCGGCTGGGGACCCCAGCACTGACGTCCCGTGGACTTTTGGAAAAAGACTTCCAAAAA
GTAGCCCACTTTATTCACAGAGGGATAGAGCTGACCCTGCAGATCCAGAGCGACACTGGT
GTCAGAGCCACCCTGAAAGAGTTCAAGGAGAGACTGGCAGGGGATAAGTACCAGGCGGCC
GTGCAGGCTCTCCGGGAGGAGGTTGAGAGCTTCGCCTCTCTCTTCCCTCTGCCTGGCCTG
CCTGACTTCTAA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
L11931

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_8_Locus:
17p11.2

# Metabolic_Enzyme_8_SNPs:
rs1979277; rs7215148; rs3783; rs1979276; rs4924750; rs12952556; rs2688030; rs7211382; rs2688036; rs9902011; rs9901707; rs11867855; rs12602780; rs2273027; rs6502648; rs2125154; rs2168781; rs4925177; rs2273029; rs4925178; rs9909104; rs4924848; rs2273028; rs4500798; rs4924849; rs9904323; rs9902498; rs9910090; rs11868708; rs2273026; rs4925176; rs7215241; rs4925174; rs17806489; rs8080285; rs12937300; rs4925175; rs7215491; rs9897954; rs6502649; rs7207306; rs11078415; rs11869515; rs3794772; rs12603682; rs1975822; rs9899244; rs12451555; rs12601687; rs8070633; rs8070162; rs7217566; rs6502650; rs12939092; rs8073464; rs7216214; rs4925180; rs638318; rs9748196; rs1975821; rs4925179; rs12451698; rs6502652; rs12949119; rs12939757; rs593297; rs10560621; rs12950117; rs12603525; rs10605292; rs2045463; rs10560620; rs1801438; rs9907815; rs34046905; rs6502651; rs28842509; rs35758894; rs35958900; rs599147; rs12603622; rs3866955; rs35176939; rs34396945; rs35675509; rs36074773; rs4924850; rs9893653; rs9891958; rs11652808; rs640629; rs28479066; rs8076444; rs35371970; rs35017109; rs9890189; rs9890744; rs12451807; rs7222930; rs9915858; rs34314562; rs3039790; rs10163522; rs8074044; rs641028; rs12952667; rs35782384; rs8074369; rs3794773; rs35005892; rs41313224; rs35818260; rs11415006; rs33997817; rs8080168; rs34157006; rs36102200; rs10655994; rs11649868; rs28823869; rs35253049; rs12450760; rs9901339; rs9905667; rs28895954; rs7219549; rs35552686; rs11649727; rs28893340; rs28630807; rs34568590; rs34135775; rs17806333; rs10669899; rs35431354; rs11659056; rs11658098; rs11649725; rs35628660; rs9891024; rs7217603; rs941454; rs2461837; rs2461838; rs4924845; rs4924846; rs4924847; rs4925169; rs4925170; rs4925171; rs4925172; rs4925173; rs638416; rs643333; rs6502646; rs669340; rs672356; rs7213472; rs8065874; rs921865; rs921866; rs921985; rs921986; rs9894406; rs9898323; rs9900382; rs9901160; rs9906010; rs9907337; rs9909530; rs9913022

# Metabolic_Enzyme_8_General_References:
8505317; 9056951; 9753690

# Metabolic_Enzyme_8_References:
17023046; 17074544

# Metabolic_Enzyme_9_ID:
5420

# Metabolic_Enzyme_9_Name:
Methylenetetrahydrofolate reductase

# Metabolic_Enzyme_9_Synonyms:
Not Available

# Metabolic_Enzyme_9_Gene_Name:
MTHFR

# Metabolic_Enzyme_9_Protein_Sequence:
>Methylenetetrahydrofolate reductase
MVNEARGNSSLNPCLEGSASSGSESSKDSSRCSTPGLDPERHERLREKMRRRLESGDKWF
SLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAGDPGSDKETSSMMIASTAVNYC
GLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGDPIGDQWEEEEGGFNYAVDLVK
HIRSEFGDYFDICVAGYPKGHPEAGSFEADLKHLKEKVSAGADFIITQLFFEADTFFRFV
KACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIE
LAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDPRRPLPWALSAHPKRREE
DVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKM
WGEELTSEESVFEVFVLYLSGEPNRNGHKVTCLPWNDEPLAAETSLLKEELLRVNRQGIL
TINSQPNINGKPSSDPIVGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHL
VNVKGENITNAPELQPNAVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIERWGKLYE
EESPSRTIIQYIHDNYFLVNLVDNDFPLDNCLWQVVEDTLELLNRPTQNARETEAP

# Metabolic_Enzyme_9_Number_of_Residues:
656

# Metabolic_Enzyme_9_Molecular_Weight:
74597

# Metabolic_Enzyme_9_Theoretical_pI:
5.00

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  methylenetetrahydrofolate reductase (NADPH) activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
Function:  methylenetetrahydrofolate reductase (NADPH) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  sulfur amino acid metabolism
Process:  methionine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine

# Metabolic_Enzyme_9_Pathway:
map00670  One carbon pool by folate

# Metabolic_Enzyme_9_Reaction:
5-methyltetrahydrofolate + NADP+ = 5,10-methylenetetrahydrofolate + NADPH + H+

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF02219:MTHFR

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 1.5.1.20

# Metabolic_Enzyme_9_GenBank_ID_Protein:
6139053

# Metabolic_Enzyme_9_SwissProt_ID:
MTHR_HUMAN (P42898)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
MTHFR

# Metabolic_Enzyme_9_Geneatlas_id:
MTHFR

# Metabolic_Enzyme_9_hgnc_id:
HGNC:7436

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Not Available

# Metabolic_Enzyme_9_Gene_Sequence:
>1971 bp
ATGGTGAACGAAGCCAGAGGAAACAGCAGCCTCAACCCCTGCTTGGAGGGCAGTGCCAGC
AGTGGCAGTGAGAGCTCCAAAGATAGTTCGAGATGTTCCACCCCGGGCCTGGACCCTGAG
CGGCATGAGAGACTCCGGGAGAAGATGAGGCGGCGATTGGAATCTGGTGACAAGTGGTTC
TCCCTGGAATTCTTCCCTCCTCGAACTGCTGAGGGAGCTGTCAATCTCATCTCAAGGTTT
GACCGGATGGCAGCAGGTGGCCCCCTCTACATAGACGTGACCTGGCACCCAGCAGGTGAC
CCTGGCTCAGACAAGGAGACCTCCTCCATGATGATCGCCAGCACCGCCGTGAACTACTGT
GGCCTGGAGACCATCCTGCACATGACCTGCTGCCGTCAGCGCCTGGAGGAGATCACGGGC
CATCTGCACAAAGCTAAGCAGCTGGGCCTGAAGAACATCATGGCGCTGCGGGGAGACCCA
ATAGGTGACCAGTGGGAAGAGGAGGAGGGAGGCTTCAACTACGCAGTGGACCTGGTGAAG
CACATCCGAAGTGAGTTTGGTGACTACTTTGACATCTGTGTGGCAGGTTACCCCAAAGGC
CACCCCGAAGCAGGGAGCTTTGAGGCTGACCTGAAGCACTTGAAGGAGAAGGTGTCTGCG
GGAGCCGATTTCATCATCACGCAGCTTTTCTTTGAGGCTGACACATTCTTCCGCTTTGTG
AAGGCATGCACCGACATGGGCATCACTTGCCCCATCGTCCCCGGGATCTTTCCCATCCAG
GGCTACCACTCCCTTCGGCAGCTTGTGAAGCTGTCCAAGCTGGAGGTGCCACAGGAGATC
AAGGACGTGATTGAGCCAATCAAAGACAACGATGCTGCCATCCGCAACTATGGCATCGAG
CTGGCCGTGAGCCTGTGCCAGGAGCTTCTGGCCAGTGGCTTGGTGCCAGGCCTCCACTTC
TACACCCTCAACCGCGAGATGGCTACCACAGAGGTGCTGAAGCGCCTGGGGATGTGGACT
GAGGACCCCAGGCGTCCCCTACCCTGGGCTCTCAGTGCCCACCCCAAGCGCCGAGAGGAA
GATGTACGTCCCATCTTCTGGGCCTCCAGACCAAAGAGTTACATCTACCGTACCCAGGAG
TGGGACGAGTTCCCTAACGGCCGCTGGGGCAATTCCTCTTCCCCTGCCTTTGGGGAGCTG
AAGGACTACTACCTCTTCTACCTGAAGAGCAAGTCCCCCAAGGAGGAGCTGCTGAAGATG
TGGGGGGAGGAGCTGACCAGTGAAGCAAGTGTCTTTGAAGTCTTTGTTCTTTACCTCTCG
GGAGAACCAAACCGGAATGGTCACAAAGTGACTTGCCTGCCCTGGAACGATGAGCCCCTG
GCGGCTGAGACCAGCCTGCTGAAGGAGGAGCTGCTGCGGGTGAACCGCCAGGGCATCCTC
ACCATCAACTCACAGCCCAACATCAACGGGAAGCCGTCCTCCGACCCCATCGTGGGCTGG
GGCCCCAGCGGGGGCTATGTCTTCCAGAAGGCCTACTTAGAGTTTTTCACTTCCCGCGAG
ACAGCGGAAGCACTTCTGCAAGTGCTGAAGAAGTACGAGCTCCGGGTTAATTACCACCTT
GTCAATGTGAAGGGTGAAAACATCACCAATGCCCCTGAACTGCAGCCGAATGCTGTCACT
TGGGGCATCTTCCCTGGGCGAGAGATCATCCAGCCCACCGTAGTGGATCCCGTCAGCTTC
ATGTTCTGGAAGGACGAGGCCTTTGCCCTGTGGATTGAGCGGTGGGGAAAGCTGTATGAG
GAGGAGTCCCCGTCCCGCACCATCATCCAGTACATCCACGACAACTACTTCCTGGTCAAC
CTGGTGGACAATGACTTCCCACTGGACAACTGCCTCTGGCAGGTGGTGGAAGACACATTG
GAGCTTCTCAACAGGCCCACCCAGAATGCGAGAGAAACGGAGGCTCCATGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
U09806

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_9_Locus:
1p36.3

# Metabolic_Enzyme_9_SNPs:
rs1801133; rs1801131; rs2066470; rs2066466; rs4846051; rs13306554; rs2066462; rs7553194; rs1931226; rs17037404; rs3753588; rs34889587; rs3753586; rs13306558; rs3753587; rs1476413; rs1994798; rs4846052; rs1572151; rs11121832; rs17367504; rs7518348; rs17037390; rs17421511; rs13306556; rs13306567; rs7545331; rs7533315; rs6541003; rs9651118; rs13306553; rs35593468; rs7537955; rs6541005; rs35529390; rs34983699; rs17421462; rs34450350; rs3766747; rs7526128; rs17421560; rs7525338; rs17037388; rs6700268; rs2274973; rs36015380; rs2066464; rs34846084; rs17375901; rs36040334; rs34840945; rs41394446; rs17037397; rs2066471; rs12121543; rs2066465; rs7527897; rs17037396; rs34825967; rs6541004; rs6541006; rs35464336; rs7535669; rs2274975; rs1413355; rs2066469; rs3927589; rs2274974; rs2066472; rs13306555; rs2066461; rs6664734; rs34279942; rs35653697; rs13306559; rs2066463; rs34511073; rs5772477; rs2066467; rs35607549; rs35514701; rs12403856; rs35959725; rs2066468; rs6681229; rs41452445; rs35424354; rs4846050; rs7547068; rs4845885; rs1057624; rs10779765; rs10864540; rs10864543; rs1106409; rs11121833; rs12123964; rs12132479; rs12134663; rs12145559; rs12404124; rs12406667; rs12564002; rs13306560; rs13306561; rs13375493; rs1537514; rs1537515; rs1537516; rs15854; rs17037420; rs17037425; rs1889292; rs1889293; rs1889294; rs2077360; rs2151654; rs2151655; rs2184226; rs2274976; rs34994762; rs35059007; rs35737219; rs3737964; rs3737965; rs3737966; rs3737967; rs3753582; rs3753583; rs3753584; rs3820192; rs4845882; rs4845883; rs4845884; rs4846039; rs4846040; rs4846041; rs4846042; rs4846043; rs4846044; rs4846045; rs4846046; rs4846048; rs4846049; rs4846054; rs4846056; rs6541001; rs6687229; rs6696752; rs6697244; rs6699881; rs7538516; rs7555034; rs7555471; rs868014; rs915014

# Metabolic_Enzyme_9_General_References:
7920641; 7951330; 9680386; 7726158; 7647779; 8940272; 9545406; 9545395; 9781030; 9719624; 10679944

# Metabolic_Enzyme_9_References:
15979267; 16002796; 16002814; 16095790

# Metabolic_Enzyme_10_ID:
8310

# Metabolic_Enzyme_10_Name:
72 kDa type IV collagenase precursor

# Metabolic_Enzyme_10_Synonyms:
72 kDa gelatinase; Matrix metalloproteinase-2; MMP-2; Gelatinase A; TBE- 1

# Metabolic_Enzyme_10_Gene_Name:
MMP2

# Metabolic_Enzyme_10_Protein_Sequence:
>72 kDa type IV collagenase precursor
MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT
SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ
IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY
WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP
GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC


# Metabolic_Enzyme_10_Number_of_Residues:
660

# Metabolic_Enzyme_10_Molecular_Weight:
73883

# Metabolic_Enzyme_10_Theoretical_pI:
5.09

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  metallopeptidase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  metalloendopeptidase activity
 ||
>>>
Process:  carbohydrate metabolism
Process:  cellular carbohydrate metabolism
Process:  peptidoglycan metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  extracellular matrix
Component:  extracellular matrix (sensu Metazoa)

# Metabolic_Enzyme_10_General_Function:
Not Available

# Metabolic_Enzyme_10_Specific_Function:
In addition to gelatin and collagens, it cleaves KiSS1 at a Gly-|-Leu bond

# Metabolic_Enzyme_10_Pathway:
Not Available

# Metabolic_Enzyme_10_Reaction:
Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00040:fn2;
PF00045:Hemopexin;
PF00413:Peptidase_M10;
PF01471:PG_binding_1

# Metabolic_Enzyme_10_Signals:
1-29

# Metabolic_Enzyme_10_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 3.4.24.24

# Metabolic_Enzyme_10_GenBank_ID_Protein:
180671

# Metabolic_Enzyme_10_SwissProt_ID:
MMP2_HUMAN (P08253)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
MMP2

# Metabolic_Enzyme_10_Geneatlas_id:
MMP2

# Metabolic_Enzyme_10_hgnc_id:
HGNC:7166

# Metabolic_Enzyme_10_PDB_ID:
1GXD

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_10_Gene_Sequence:
>1936 bp
CCTCTGTCTCCTGGGCTGCCTGCTGAGCCACGCCGCCGCCGCGCCGTCGCCCATCATCAA
GTTCCCCGGCGATGTCGCCCCCAAAACGGACAAAGAGTTGGCAGTGCAATACCTGAACAC
CTTCTATGGCTGCCCCAAGGAGAGCTGCAACCTGTTTGTGCTGAAGGACACACTAAAGAA
GATGCAGAAGTTCTTTGGACTGCCCCAGACAGGTGATCTTGACCAGAATACCATCGAGAC
CATGCGGAAGCCACGCTGCGGCAACCCAGATGTGGCCAACTACAACTTCTTCCCTCGCAA
GCCCAAGTGGGACAAGAACCAGATCACATACAGGATCATCGGCTACACACCTGATCTGGA
CCCAGAGACAGTGGATGATGCCTTTGCTCGTGCCTTCCAAGTCTGGAGCGATGTGACCCC
ACTGCGGTTTTCTCGAATCCATGATGGAGAGGCAGACATCATGATCAACTTTGGCCGCTG
GGAGCATGGCGATGGATACCCCTTTGACGGTAAGGACGGACTCCTGGCTCATGCCTTCGC
CCCAGGCACTGGTGTTGGGGGAGACTCCCATTTTGATGACGATGAGCTATGGACCTTGGG
AGAAGGCCAAGTGGTCCGTGTGAAGTATGGGAACGCCGATGGGGAGTACTGCAAGTTCCC
CTTCTTGTTCAATGGCAAGGAGTACAACAGCTGCACTGATACTGGCCGCAGCGATGGCTT
CCTCTGGTGCTCCACCACCTACAACTTTGAGAAGGATGGCAAGTACGGCTTCTGTCCCCA
TGAAGCCCTGTTCACCATGGGCGGCAACGCTGAAGGACAGCCCTGCAAGTTTCCATTCCG
CTTCCAGGGCACATCCTATGACAGCTGCACCACTGAGGGCCGCACGGATGGCTACCGCTG
GTGCGGCACCACTGAGGACTACGACCGCGACAAGAAGTATGGCTTCTGCCCTGAGACCGC
CATGTCCACTGTTGGTGGGAACTCAGAAGGTGCCCCCTGTGTCTTCCCCTTCACTTTCCT
GGGCAACAAATATGAGAGCTGCACCAGCGCCGGCCGCAGTGACGGAAAGATGTGGTGTGC
GACCACAGCCAACTACGATGACGACCGCAAGTGGGGCTTCTGCCCTGACCAAGGGTACAG
CCTGTTCCTCGTGGCAGCCCACGAGTTTGGCCACGCCATGGGGCTGGAGCACTCCCAAGA
CCCTGGGGCCCTGATGGCACCCATTTACACCTACACCAAGAACTTCCGTCTGTCCCAGGA
TGACATCAAGGGCATTCAGGAGCTCTATGGGGCCTCTCCTGACATTGACCTTGGCACCGG
CCCCACCCCCACACTGGGCCCTGTCACTCCTGAGATCTGCAAACAGGACATTGTATTTGA
TGGCATCGCTCAGATCCGTGGTGAGATCTTCTTCTTCAAGGACCGGTTCATTTGGCGGAC
TGTGACGCCACGTGACAAGCCCATGGGGCCCCTGCTGGTGGCCACATTCTGGCCTGAGCT
CCCGGAAAAGATTGATGCGGTATACGAGGCCCCACAGGAGGAGAAGGCTGTGTTCTTTGC
AGGGAATGAATACTGGATCTACTCAGCCAGCACCTTGGAGCGAGGGTACCCCAAGCCACT
GACCAGCCTGGGACTGCCCCCTGATGTCCAGCGAGTGGATGCCGCCTTTAACTGGAGCAA
AAACAAGAAGACATACATCTTTGCTGGAGACAAATTCTGGAGATACAATGAGGTGAAGAA
GAAAATGGATCCTGGCTTCCCCAAGCTCATCGCAGATGCCTGGAATGCCATCCCCGATAA
CCTGGATGCCGTCGTGGACCTGCAGGGCGGCGGTCACAGCTACTTCTTCAAGGGTGCCTA
TTACCTGAAGCTGGAGAACCAAAGTCTGAAGAGCGTGAAGTTTGGAAGCATCAAATCCGA
CTGGCTAGGCTGCTGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
J03210

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_10_Locus:
16q13-q21

# Metabolic_Enzyme_10_SNPs:
rs16955280; rs243849; rs1053605; rs10775332; rs1132896; rs11541998; rs2287074; rs16955236; rs2052264; rs7201; rs17860019; rs2287073; rs17860021; rs15142; rs1799818; rs1477017; rs243832; rs243839; rs243844; rs243842; rs243834; rs243840; rs11640428; rs1030869; rs243836; rs837546; rs837547; rs183112; rs2287076; rs243837; rs1992116; rs243846; rs857403; rs866770; rs243845; rs243841; rs857402; rs243833; rs243835; rs9928731; rs243847; rs1030870; rs12923011; rs9302671; rs9939185; rs9936955; rs1992115; rs243862; rs8055959; rs243843; rs243838; rs1946773; rs865094; rs6499763; rs12598301; rs12934241; rs17860007; rs17859880; rs17859912; rs9923304; rs17859930; rs11076101; rs17859885; rs17859977; rs16955243; rs1030868; rs17860008; rs2241145; rs16955212; rs17859898; rs17859990; rs12599775; rs16955228; rs17859925; rs11639960; rs17859937; rs17860013; rs16955224; rs2287075; rs708269; rs17859886; rs17859974; rs17859889; rs17859882; rs17859958; rs17859975; rs16955268; rs17243002; rs11863252; rs2241146; rs17859910; rs171498; rs16955260; rs11646643; rs17859841; rs7184360; rs17301608; rs17242473; rs17859942; rs17859859; rs17859956; rs9923164; rs17859866; rs243848; rs17859878; rs17859934; rs17859978; rs16955273; rs17859994; rs17859908; rs17859927; rs17859894; rs17859991; rs17859950; rs17859867; rs17859881; rs171497; rs17859913; rs17859871; rs17859890; rs17859976; rs17859968; rs17859920; rs17859855; rs17859856; rs17859837; rs17859989; rs17859972; rs17859851; rs17859940; rs17859992; rs17859979; rs17859853; rs17859922; rs17860010; rs17859865; rs17859993; rs17860017; rs17859854; rs17859995; rs17859919; rs17859997; rs17859838; rs243831; rs11865501; rs243866; rs243865; rs243830; rs2052265; rs17859817; rs17859819; rs2285052; rs17859829; rs17859816; rs17859821; rs243864; rs2285053; rs17859827; rs41459945; rs11542001; rs17859943; rs243863; rs28730814; rs41503347; rs41513346; rs41521545; rs1063977; rs1063976; rs35646586; rs1799839; rs1058373; rs1063978; rs41280909; rs17860023; rs1799840; rs11541999; rs187228; rs36115725; rs17859832; rs17860024; rs8059615; rs17859844; rs17859873; rs17859839; rs17859843; rs17859911; rs17860011; rs3996855; rs10625273; rs28392975; rs17859884; rs17859905; rs17860000; rs865095; rs17859914; rs7206229; rs17859902; rs17859845; rs17859874; rs34939163; rs17860012; rs17860009; rs34264316; rs17859932; rs41280907; rs17859893; rs12919236; rs17859973; rs17860002; rs17859840; rs17859901; rs35129615; rs35420043; rs12445370; rs17859903; rs35909165; rs34621950; rs17859951; rs17859875; rs17859870; rs17859847; rs35367564; rs34123566; rs17859896; rs17859895; rs17859959; rs17859963; rs17859964; rs17859948; rs17859933; rs17860014; rs28730813; rs17859891; rs12919779; rs35887028; rs12922542; rs17859980; rs17859998; rs17859929; rs17860015; rs17859924; rs17859835; rs10670193; rs8054776; rs17859971; rs17859961; rs17859868; rs34871383; rs17859999; rs9932439; rs17859960; rs17859857; rs17859909; rs35242322; rs28730812; rs35472030; rs17859869; rs17859858; rs17859981; rs3214373; rs5817013; rs33937239; rs10548685; rs34036359; rs17859831; rs17859823; rs34377253; rs41400448; rs17860025; rs17859830; rs17859826; rs17859813; rs17859815; rs34814653; rs17859828; rs17860027; rs17859824; rs17859820; rs1005912; rs1005913; rs11076099; rs11076102; rs1116195; rs11643630; rs11861520; rs11865658; rs12373066; rs12446205; rs12599478; rs12599483; rs12708952; rs12918208; rs12930259; rs1347653; rs1362399; rs1561219; rs1561220; rs1583585; rs1583587; rs16955194; rs16955289; rs17302903; rs1861319; rs1861320; rs2192852; rs2192853; rs2241148; rs243828; rs243829; rs2859482; rs4454968; rs4454969; rs4454970; rs4627342; rs7189232; rs8054459; rs9922534

# Metabolic_Enzyme_10_General_References:
2834383; 1851724; 2162831; 2158484; 12879005; 7583664; 8549817

# Metabolic_Enzyme_10_References:
16377938

# Metabolic_Enzyme_11_ID:
8257

# Metabolic_Enzyme_11_Name:
Methionine synthase

# Metabolic_Enzyme_11_Synonyms:
5-methyltetrahydrofolate-- homocysteine methyltransferase; Methionine synthase, vitamin-B12 dependent; MS

# Metabolic_Enzyme_11_Gene_Name:
MTR

# Metabolic_Enzyme_11_Protein_Sequence:
>Methionine synthase
MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHA
RPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMC
SAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQA
KGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQT
GEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDET
PSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGL
EPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDG
MLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDD
FLEKARKIKKYGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNI
LTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLY
HAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKV
IQTDEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVG
DLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATV
KGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEM
IFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDEN
LKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQV
FEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTL
ISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYY
CLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEE
LHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTG
IRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPIL
GYDTD

# Metabolic_Enzyme_11_Number_of_Residues:
1265

# Metabolic_Enzyme_11_Molecular_Weight:
140529

# Metabolic_Enzyme_11_Theoretical_pI:
5.27

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  homocysteine S-methyltransferase activity
Function:  vitamin binding
Function:  cobalamin binding
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  S-methyltransferase activity
Function:  methionine synthase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  dihydropteroate synthase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  cobalt ion binding
 ||
>>>
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  sulfur amino acid metabolism
Process:  sulfur amino acid biosynthesis
Process:  methionine biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  aromatic compound metabolism
Process:  folic acid and derivative metabolism
Process:  folic acid and derivative biosynthesis
 ||
>>>
Component:  cell
Component:  intracellular

# Metabolic_Enzyme_11_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate

# Metabolic_Enzyme_11_Pathway:
map00271  Methionine metabolism;
 map00670  One carbon pool by folate

# Metabolic_Enzyme_11_Reaction:
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF02310:B12-binding;
PF02607:B12-binding_2;
PF02965:Met_synt_B12;
PF00809:Pterin_bind;
PF02574:S-methyl_trans

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.1.1.13

# Metabolic_Enzyme_11_GenBank_ID_Protein:
1923221

# Metabolic_Enzyme_11_SwissProt_ID:
METH_HUMAN (Q99707)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
MTR

# Metabolic_Enzyme_11_Geneatlas_id:
MTR

# Metabolic_Enzyme_11_hgnc_id:
HGNC:7468

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_11_Gene_Sequence:
>3798 bp
ATGTCACCCGCGCTCCAAGACCTGTCGCAACCCGAAGGTCTGAAGAAAACCCTGCGGGAT
GAGATCAATGCCATTCTGCAGAAGAGGATTATGGTGCTGGATGGAGGGATGGGGACCATG
ATCCAGCGGGAGAAGCTAAACGAAGAACACTTCCGAGGTCAGGAATTTAAAGATCATGCC
AGGCCGCTGAAAGGCAACAATGACATTTTAAGTATAACTCAGCCTGATGTCATTTACCAA
ATCCATAAGGAATACTTGCTGGCTGGGGCAGATATCATTGAAACAAATACTTTTAGCAGC
ACTAGTATTGCCCAAGCTGACTATGGCCTTGAACACTTGGCCTACCGGATGAACATGTGC
TCTGCAGGAGTGGCCAGAAAAGCTGCCGAGGAGGTAACTCTCCAGACAGGAATTAAGAGG
TTTGTGGCAGGGGCTCTGGGTCCGACTAATAAGACACTCTCTGTGTCCCCATCTGTGGAA
AGGCCGGATTATAGGAACATCACATTTGATGAGCTTGTTGAAGCATACCAAGAGCAGGCC
AAAGGACTTCTGGATGGCGGGGTTGATATCTTACTCATTGAAACTATTTTTGATACTGCC
AATGCCAAGGCAGCCTTGTTTGCACTCCAAAATCTTTTTGAGGAGAAATATGCTCCCCGG
CCTATCTTTATTTCAGGGACGATCGTTGATAAAAGTGGGCGGACTCTTTCCGGACAGACA
GGAGAGGGATTTGTCATCAGCGTGTCTCATGGAGAACCACTCTGCATTGGATTAAATTGT
GCTTTGGGTGCAGCTGAGATGAGACCTTTTATTGAAATAATTGGAAAATGTACAACAGCC
TATGTCCTCTGTTATCCCAATGCAGGTCTTCCCAACACCTTTGGTGACTATGATGAAACG
CCTTCTATGATGGCCAAGCACCTAAAGGATTTTGCTATGGATGGCTTGGTCAATATAGTT
GGAGGATGCTGTGGGTCAACACCAGATCATATCAGGGAAATTGCTGAAGCTGTGAAAAAT
TGTAAGCCTAGAGTTCCACCTGCCACTGCTTTTGAAGGACATATGTTACTGTCTGGTCTA
GAGCCCTTCAGGATTGGACCGTACACCAACTTTGTTAACATTGGAGAGCGCTGTAATGTT
GCAGGATCAAGGAAGTTTGCTAAACTCATCATGGCAGGAAACTATGAAGAAGCCTTGTGT
GTTGCCAAAGTGCAGGTGGAAATGGGAGCCCAGGTGTTGGATGTCAACATGGATGATGGC
ATGCTAGATGGTCCAAGTGCAATGACCAGATTTTGCAACTTAATTGCTTCCGAGCCAGAC
ATCGCAAAGGTACCTTTGTGCATCGACTCCTCCAATTTTGCTGTGATTGAAGCTGGGTTA
AAGTGCTGCCAAGGGAAGTGCATTGTCAATAGCATTAGTCTGAAGGAAGGAGAGGACGAC
TTCTTGGAGAAGGCCAGGAAGATTAAAAAGTATGGAGCTGCTATGGTGGTCATGGCTTTT
GATGAAGAAGGACAGGCAACAGAAACAGACACAAAAATCAGAGTGTGCACCCGGGCCTAC
CATCTGCTTGTGAAAAAACTGGGCTTTAATCCAAATGACATTATTTTTGACCCTAATATC
CTAACCATTGGGACTGGAATGGAGGAACACAACTTGTATGCCATTAATTTTATCCATGCA
ACAAAAGTCATTAAAGAAACATTACCTGGAGCCAGAATAAGTGGAGGTCTTTCCAACTTG
TCCTTCTCCTTCCGAGGAATGGAAGCCATTCGAGAAGCAATGCATGGGGTTTTCCTTTAC
CATGCAATCAAGTCTGGCATGGACATGGGGATAGTGAATGCTGGAAACCTCCCTGTGTAT
GATGATATCCATAAGGAACTTCTGCAGCTCTGTGAAGATCTCATCTGGAATAAAGACCCT
GAGGCCACTGAGAAGCTCTTACGTTATGCCCAGACTCAAGGCACAGGAGGGAAGAAAGTC
ATTCAGACTGATGAGTGGAGAAATGGCCCTGTCGAAGAACGCCTTGAGTATGCCCTTGTG
AAGGGCATTGAAAAACATATTATTGAGGATACTGAGGAAGCCAGGTTAAACCAAAAAAAA
TATCCCCGACCTCTCAATATAATTGAAGGACCCCTGATGAATGGAATGAAAATTGTTGGT
GATCTTTTTGGAGCTGGAAAAATGTTTCTACCTCAGGTTATAAAGTCAGCCCGGGTTATG
AAGAAGGCTGTTGGCCACCTTATCCCTTTCATGGAAAAAGAAAGAGAAGAAACCAGAGTG
CTTAACGGCACAGTAGAAGAAGAGGACCCTTACCAGGGCACCATCGTGCTGGCCACTGTT
AAAGGCGACGTGCACGACATAGGCAAGAACATAGTTGGAGTAGTCCTTGGCTGCAATAAT
TTCCGAGTTATTGATTTAGGAGTCATGACTCCATGTGATAAGATACTGAAAGCTGCTCTT
GACCACAAAGCAGATATAATTGGCCTGTCAGGACTCATCACTCCTTCCCTGGATGAAATG
ATTTTTGTTGCCAAGGAAATGGAGAGATTAGCTATAAGGATTCCATTGTTGATTGGAGGA
GCAACCACTTCAAAAACCCACACAGCAGTTAAAATAGCTCCGAGATACAGTGCACCTGTA
ATCCATGTCCTGGACGCGTCCAAGAGTGTGGTGGTGTGTTCCCAGCTGTTAGATGAAAAT
CTAAAGGATGAATACTTTGAGGAAATCATGGAAGAATATGAAGATATTAGACAGGACCAT
TATGAGTCTCTCAAGGAGAGGAGATACTTACCCTTAAGTCAAGCCAGAAAAAGTGGTTTC
CAAATGGATTGGCTGTCTGAACCTCACCCAGTGAAGCCCACGTTTATTGGGACCCAGGTC
TTTGAAGACTATGACCTGCAGAAGCTGGTGGACTACATTGACTGGAAGCCTTTCTTTGAT
GTCTGGCAGCTCCGGGGCAAGTACCCGAATCGAGGCTTCCCCAAGATATTTAACGACAAA
ACAGTAGGTGGAGAGGCCAGGAAGGTCTACGATGATGCCCACAATATGCTGAACACACTG
ATTAGTCAAAAGAAACTCCGGGCCCGGGGTGTGGTTGGGTTCTGGCCAGCACAGAGTATC
CAAGACGACATTCACCTGTACGCAGAGGCTGCTGTGCCCCAGGCTGCAGAGCCCATAGCC
ACTTTCTATGGGTTAAGGCAACAGGCTGAGAAGGACTCTGCCAGCACGGAGCCATACTAC
TGCCTCTCAGACTTCATCGCTCCCTTGCATTCTGGCATCCGTGACTACCTGGGCCTGTTT
GCCGTTGCCTGCTTTGGGGTAGAAGAGCTGAGCAAGGCCTATGAGGATGATGGTGACGAC
TACAGCAGCATCATGGTCAAGGCGCTGGGGGACCGGCTGGCAGAGGCCTTTGCAGAAGAG
CTCCATGAAAGAGTTCGCCGAGAACTGTGGGCCTACTGTGGCAGTGAGCAGCTGGACGTC
GCAGACCTGCGAAGGTTGCGGTACAAGGGCATCCGCCCGGCTCCTGGCTACCCCAGCCAG
CCCGACCACACCGAGAAGCTCACCATGTGGAGACTCGCAGACATCGAGCAGTCTACAGGC
ATTAGGTTAACAGAATCATTAGCAATGGCACCTGCTTCAGCAGTCTCAGGCCTCTACTTC
TCCAATTTGAAGTCCAAATATTTTGCTGTGGGGAAGATTTCCAAGGATCAGGTTGAGGAT
TATGCATTGAGGAAGAACATATCTGTGGCTGAGGTTGAGAAATGGCTTGGACCCATTTTG
GGATATGATACAGACTAA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
U71285

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_11_Locus:
1q43

# Metabolic_Enzyme_11_SNPs:
rs1805087; rs10737812; rs16834521; rs1050993; rs2853522; rs1804742; rs2853523; rs3768159; rs11799670; rs1050996; rs10925263; rs1131450; rs3738547; rs3768160; rs12058328; rs9779; rs2275565; rs2236573; rs1266164; rs2275568; rs2297965; rs946403; rs1770449; rs1806505; rs2185471; rs2385511; rs1252252; rs2712829; rs10925251; rs10802565; rs4659744; rs4659724; rs4659723; rs3795708; rs2385504; rs3768155; rs4659738; rs2275566; rs7526063; rs4659476; rs10158222; rs10754584; rs10802569; rs4659729; rs3754255; rs10733117; rs4659743; rs2385512; rs4659730; rs3768150; rs4077829; rs4639750; rs10733118; rs3820568; rs10925250; rs12563688; rs4659745; rs10925258; rs10925261; rs3820571; rs4659725; rs10802564; rs10925235; rs4659739; rs12354209; rs6682427; rs2275564; rs3768141; rs3768142; rs10925233; rs3890786; rs7551985; rs2282369; rs3737291; rs2297967; rs2185208; rs2066190; rs4659736; rs10158822; rs10925259; rs3820569; rs10925254; rs12567062; rs3768145; rs3768139; rs3768132; rs4659726; rs10925248; rs1856769; rs6668344; rs10925236; rs3768148; rs7541539; rs10495385; rs4598478; rs6668438; rs2385569; rs4659479; rs10925249; rs12060570; rs11800413; rs883395; rs3768135; rs17599657; rs3768152; rs12096955; rs10495384; rs3768149; rs2297966; rs3845567; rs6660700; rs12097647; rs10802570; rs2789352; rs10925247; rs2066191; rs10925241; rs10495387; rs10925257; rs7540612; rs10925260; rs2297964; rs12138911; rs2385500; rs7536446; rs3820573; rs12093482; rs3768156; rs11576943; rs3768138; rs3768144; rs7527957; rs10802566; rs10495386; rs12562226; rs3768153; rs6694576; rs10802568; rs883396; rs4659727; rs10925252; rs10925242; rs2385568; rs7525347; rs955516; rs4659731; rs7516758; rs12407420; rs16834527; rs7534947; rs10925240; rs12070633; rs11589672; rs4500304; rs12094071; rs16834490; rs7514137; rs12066434; rs16834475; rs12090960; rs16834402; rs34991146; rs16834418; rs2275400; rs12039633; rs3768136; rs16834465; rs10925253; rs16834516; rs10802567; rs16834510; rs12060264; rs3768140; rs4659737; rs12049580; rs3901559; rs4659741; rs10925234; rs12136861; rs6665348; rs2891796; rs12065382; rs12759827; rs17658475; rs4545327; rs7519180; rs10925262; rs12047554; rs2385509; rs12096325; rs12129440; rs12059215; rs3768147; rs7517015; rs7546675; rs16834519; rs10925246; rs7527176; rs3768137; rs12065561; rs12093006; rs12022937; rs3768154; rs10925243; rs2297968; rs12094067; rs16834406; rs2275567; rs10925239; rs12096821; rs3820570; rs4456082; rs10399834; rs6701372; rs12072008; rs12022198; rs3768151; rs4659740; rs4659735; rs11802532; rs6657167; rs28372869; rs28372867; rs28372868; rs16834388; rs3768161; rs11799647; rs12749581; rs12070777; rs12030699; rs34672910; rs34877975; rs35177227; rs2853639; rs12561937; rs34686098; rs35107824; rs3738548; rs1050992; rs41305572; rs34432798; rs34899082; rs3831323; rs34042661; rs36046613; rs36013971; rs35458318; rs11315816; rs28570085; rs12138233; rs1268563; rs12117459; rs12029689; rs35687492; rs12731423; rs2712832; rs35092440; rs10581765; rs4521982; rs10561343; rs4659734; rs12735148; rs12024034; rs17598102; rs12354279; rs2185417; rs10675878; rs35616019; rs1271481; rs11478942; rs2791956; rs955515; rs35478140; rs34433980; rs4659732; rs35971499; rs1770585; rs1252482; rs12040912; rs12044369; rs2011943; rs35639320; rs12038350; rs12730877; rs12093994; rs35888207; rs5781925; rs16834420; rs34152972; rs35147969; rs34922580; rs3768143; rs12080662; rs12120433; rs34750969; rs34712768; rs12024711; rs1252251; rs34718091; rs34832362; rs3835677; rs36073004; rs12143890; rs2712831; rs4006389; rs11363843; rs34414656; rs10644490; rs35668201; rs36109542; rs12143889; rs41295948; rs35252833; rs35840272; rs10925255; rs2791957; rs11809449; rs12078297; rs4659742; rs12749287; rs34182535; rs1252254; rs5781926; rs3856242; rs10925245; rs11288788; rs3795707; rs35789760; rs5781924; rs28558923; rs2792274; rs35511250; rs34232615; rs41269359; rs1770584; rs2791955; rs3890848; rs35864633; rs34466832; rs1624004; rs11472899; rs16834466; rs3054157; rs12037527; rs12082167; rs41530146; rs11358481; rs16834433; rs35815932; rs1556871; rs8179317; rs36066151; rs34338840; rs34305921; rs35913043; rs12087359; rs36075640; rs6681710; rs6658027; rs34559766; rs34616890; rs16834396; rs34999138; rs16834501; rs34111292; rs35025237; rs12073644; rs11584644; rs16834391; rs41304165; rs28372871; rs41305961; rs35664469; rs41305971; rs28372870; rs34421688; rs35351871; rs1047027; rs1047052; rs10925237; rs10925238; rs10925264; rs10925265; rs10925266; rs10925267; rs10925269; rs1150180; rs11803836; rs11806016; rs12034079; rs12062747; rs12066406; rs12075101; rs12075824; rs12089156; rs12137040; rs12563463; rs14354; rs16831987; rs16834387; rs16834539; rs16834541; rs16834549; rs1815605; rs2282368; rs2712830; rs2791958; rs3738549; rs3738550; rs3738551; rs4659728; rs4659747; rs6662510; rs6676866; rs6677090; rs6679990; rs6680753; rs946938; rs9803986

# Metabolic_Enzyme_11_General_References:
8968737; 8968735; 9013615; 8968736

# Metabolic_Enzyme_11_References:
16709328; 16861746; 17151354

# Metabolic_Enzyme_12_ID:
8277

# Metabolic_Enzyme_12_Name:
Methionine synthase reductase, mitochondrial precursor

# Metabolic_Enzyme_12_Synonyms:
MSR

# Metabolic_Enzyme_12_Gene_Name:
MTRR

# Metabolic_Enzyme_12_Protein_Sequence:
>Methionine synthase reductase, mitochondrial precursor
MGAASVRAGARLVEVALCSFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSA
DLHCISESDKYDLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGL
LGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKH
FRSSRGQEEISGALPVASPASLRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVN
SNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQVSVTSADPV
FQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQL
EDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTS
DSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPY
SCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSG
KALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGA
MWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEEEAPAKYVQDNIQLHG
QQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYL
QDIWS

# Metabolic_Enzyme_12_Number_of_Residues:
725

# Metabolic_Enzyme_12_Molecular_Weight:
80437

# Metabolic_Enzyme_12_Theoretical_pI:
6.47

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
Function:  transporter activity
Function:  electron transporter activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_12_Specific_Function:
Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state

# Metabolic_Enzyme_12_Pathway:
Not Available

# Metabolic_Enzyme_12_Reaction:
2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP+ = 2 [methionine synthase]-cob(I)alamin + NADPH + H+ + 2 S-adenosylLmethionine

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00667:FAD_binding_1;
PF00258:Flavodoxin_1;
PF00175:NAD_binding_1

# Metabolic_Enzyme_12_Signals:
1-24

# Metabolic_Enzyme_12_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 1.16.1.8

# Metabolic_Enzyme_12_GenBank_ID_Protein:
6572540

# Metabolic_Enzyme_12_SwissProt_ID:
MTRR_HUMAN (Q9UBK8)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
MTRR

# Metabolic_Enzyme_12_Geneatlas_id:
MTRR

# Metabolic_Enzyme_12_hgnc_id:
HGNC:7473

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Isoform B:Cytoplasm. Isoform C:Cytoplasm. Isoform A:Mitochondrion (Probable)

# Metabolic_Enzyme_12_Gene_Sequence:
>2178 bp
ATGGGCGCTGCGTCAGTGCGCGCTGGCGCAAGGTTGGTGGAAGTCGCGTTGTGCAGTTTC
ACTGTTACATGCCTTGAAGTGATGAGGAGGTTTCTGTTACTATATGCTACACAGCAGGGA
CAGGCAAAGGCCATCGCAGAAGAAATGTGTGAGCAAGCTGTGGTACATGGATTTTCTGCA
GATCTTCACTGTATTAGTGAATCCGATAAGTATGACCTAAAAACCGAAACAGCTCCTCTT
GTTGTTGTGGTTTCTACCACGGGCACCGGAGACCCACCCGACACAGCCCGCAAGTTTGTT
AAGGAAATACAGAACCAAACACTGCCGGTTGATTTCTTTGCTCACCTGCGGTATGGGTTA
CTGGGTCTCGGTGATTCAGAATACACCTACTTTTGCAATGGGGGGAAGATAATTGATAAA
CGACTTCAAGAGCTTGGAGCCCGGCATTTCTATGACACTGGACATGCAGATGACTGTGTA
GGTTTAGAACTTGTGGTTGAGCCGTGGATTGCTGGACTCTGGCCAGCCCTCAGAAAGCAT
TTTAGGTCAAGCAGAGGACAAGAGGAGATAAGTGGCGCACTCCCGGTGGCATCACCTGCA
TCCTTGAGGACAGACCTTGTGAAGTCAGAGCTGCTACACATTGAATCTCAAGTCGAGCTT
CTGAGATTCGATGATTCAGGAAGAAAGGATTCTGAGGTTTTGAAGCAAAATGCAGTGAAC
AGCAACCAATCCAATGTTGTAATTGAAGACTTTGAGTCCTCACTTACCCGTTCGGTACCC
CCACTCTCACAAGCCTCTCTGAATATTCCTGGTTTACCCCCAGAATATTTACAGGTACAT
CTGCAGGAGTCTCTTGGCCAGGAGGAAAGCCAAGTATCTGTGACTTCAGCAGATCCAGTT
TTTCAAGTGCCAATTTCAAAGGCAGTTCAACTTACTACGAATGATGCCATAAAAACCACT
CTGCTGGTAGAATTGGACATTTCAAATACAGACTTTTCCTATCAGCCTGGAGATGCCTTC
AGCGTGATCTGCCCTAACAGTGATTCTGAGGTACAAAGCCTACTCCAAAGACTGCAGCTT
GAAGATAAAAGAGAGCACTGCGTCCTTTTGAAAATAAAGGCAGACACAAAGAAGAAAGGA
GCTACCTTACCCCAGCATATACCTGCGGGATGTTCTCTCCAGTTCATTTTTACCTGGTGT
CTTGAAATCCGAGCAATTCCTAAAAAGGCATTTTTGCGAGCCCTTGTGGACTATACCAGT
GACAGTGCTGAAAAGCGCAGGCTACAGGAGCTGTGCAGTAAACAAGGGGCAGCCGATTAT
AGCCGCTTTGTACGAGATGCCTGTGCCTGCTTGTTGGATCTCCTCCTCGCTTTCCCTTCT
TGCCAGCCACCACTCAGTCTCCTGCTCGAACATCTTCCTAAACTTCAACCCAGACCATAT
TCGTGTGCAAGCTCAAGTTTATTTCACCCAGGAAAGCTCCATTTTGTCTTCAACATTGTG
GAATTTCTGTCTACTGCCACAACAGAGGTTCTGCGGAAGGGAGTATGTACAGGCTGGCTG
GCCTTGTTGGTTGCTTCAGTTCTTCAGCCAAACATACATGCATCCCATGAAGACAGCGGG
AAAGCCCTGGCTCCTAAGATATCCATCTCTCCTCGAACAACAAATTCTTTCCACTTACCA
GATGACCCCTCAATCCCCATCATAATGGTGGGTCCAGGAACCGGCATAGCCCCGTTTATT
GGGTTCCTACAACATAGAGAGAAACTCCAAGAACAACACCCAGATGGAAATTTTGGAGCA
ATGTGGTTGTTTTTTGGCTGCAGGCATAAGGATAGGGATTATCTATTCAGAAAAGAGCTC
AGACATTTCCTTAAGCATGGGATCTTAACTCATCTAAAGGTTTCCTTCTCAAGAGATGCT
CCTGTTGGGGAGGAGGAAGCCCCAGCAAAGTATGTACAAGACAACATCCAGCTTCATGGC
CAGCAGGTGGCGAGAATCCTCCTCCAGGAGAACGGCCATATTTATGTGTGTGGAGATGCA
AAGAATATGGCCAAGGATGTACATGATGCCCTTGTGCAAATAATAAGCAAAGAGGTTGGA
GTTGAAAAACTAGAAGCAATGAAAACCCTGGCCACTTTAAAAGAAGAAAAACGCTACCTT
CAGGATATTTGGTCATAA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
AF121213

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_12_Locus:
5p15.3-p15.2

# Metabolic_Enzyme_12_SNPs:
rs162036; rs1532268; rs10380; rs2287780; rs10064631; rs2303080; rs16879334; rs161870; rs12347; rs6874544; rs1802059; rs2287779; rs34172797; rs35890938; rs9282786; rs8659; rs9332; rs327591; rs9282787; rs9282789; rs9282788; rs10520873; rs1802060; rs9282790; rs162038; rs326122; rs161871; rs326121; rs326124; rs162049; rs162031; rs2303081; rs162045; rs7730643; rs162034; rs7703033; rs162035; rs162131; rs162048; rs2277957; rs6555501; rs7704596; rs162033; rs3776465; rs327592; rs162037; rs716537; rs162047; rs162032; rs161869; rs162051; rs3776460; rs10520874; rs3797191; rs162043; rs3815743; rs326120; rs162039; rs3822443; rs162044; rs10040859; rs17267737; rs3776467; rs162050; rs326123; rs16879356; rs6868871; rs2277958; rs3822441; rs6859960; rs49672; rs3776455; rs327593; rs2303079; rs3776463; rs12656618; rs3836787; rs4001964; rs16879305; rs435836; rs12654509; rs10475399; rs9282791; rs6879300; rs326981; rs2308001; rs3776454; rs7722483; rs3776464; rs16879367; rs16879342; rs3756439; rs2287781; rs2308000; rs17267793; rs6870678; rs162040; rs16879316; rs11949523; rs6864295; rs16879355; rs41283145; rs41282641; rs35587995; rs34694972; rs36045697; rs9218; rs12109079; rs34927942; rs34732004; rs13181011; rs6872300; rs33961116; rs457129; rs3822444; rs7725672; rs3822442; rs36038785; rs2640668; rs35462089; rs34791262; rs11276001; rs11325590; rs2640671; rs34966478; rs35400615; rs34133380; rs34209341; rs11417443; rs11324670; rs6148899; rs162041; rs3756438; rs11345492; rs326125; rs162046; rs3776458; rs5865743; rs3776457; rs467102; rs35558077; rs34487083; rs2303082; rs10613827; rs2914032; rs34590395; rs10069646; rs13361303; rs13163363; rs17208190; rs34834130; rs35035568; rs162053; rs441581; rs4478290; rs10475398; rs435841; rs13189728; rs10059607; rs34051050; rs162042; rs41282643; rs34411979; rs11743268; rs447434; rs2624236; rs416455; rs28515801; rs162052; rs6886291; rs11739527; rs41283147; rs36226225; rs6873330; rs6876840; rs35948182; rs5865744; rs11740089; rs17208127; rs3214449; rs13190084; rs10063972; rs35657622; rs11397585; rs13161857; rs34901529; rs10057956; rs10066017; rs1046012; rs1046014; rs10512930; rs10512931; rs11134265; rs11749024; rs11951657; rs12108985; rs12109146; rs12653464; rs13154074; rs13154459; rs13166314; rs13183229; rs1384232; rs161875; rs162024; rs162026; rs162027; rs162029; rs162030; rs162270; rs162271; rs16879236; rs16879237; rs16879248; rs16879258; rs16879259; rs16879402; rs17184211; rs17245023; rs1801394; rs2170502; rs2307116; rs2966952; rs326119; rs327585; rs327586; rs327587; rs327588; rs327589; rs3733781; rs3733782; rs3733784; rs3822445; rs6413426; rs7715062; rs7727290

# Metabolic_Enzyme_12_General_References:
10564814; 9501215; 10484769; 10444342

# Metabolic_Enzyme_12_References:
16169148; 16861746; 17023046

# Macromolecular_Interacting_Partner_1_ID:
6070

# Macromolecular_Interacting_Partner_1_Name:
Dihydrofolate reductase

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
DHFR

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Dihydrofolate reductase
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
187

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
21453

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.60

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NADP binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
Function:  dihydrofolate reductase activity
 ||
>>>
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
Process:  glycine biosynthesis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Coenzyme transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8- dihydrofolate + NADPH

# Macromolecular_Interacting_Partner_1_Pathway:
map00670  One carbon pool by folate;
 map00790  Folate biosynthesis

# Macromolecular_Interacting_Partner_1_Reaction:
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00186:DHFR_1

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 1.5.1.3

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
182724

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
DYR_HUMAN (P00374)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
DHFR

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
DHFR

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:2861

# Macromolecular_Interacting_Partner_1_PDB_ID:
1MVT

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>564 bp
ATGGTTGGTTCGCTAAACTGCATCGTCGCTGTGTCCCAGAACATGGGCATCGGCAAGAAC
GGGGACCTGCCCTGGCCACCGCTCAGGAATGAATTCAGATATTTCCAGAGAATGACCACA
ACCTCTTCAGTAGAAGGTAAACAGAATCTGGTGATTATGGGTAAGAAGACCTGGTTCTCC
ATTCCTGAGAAGAATCGACCTTTAAAGGGTAGAATTAATTTAGTTCTCAGCAGAGAACTC
AAGGAACCTCCACAAGGAGCTCATTTTCTTTCCAGAAGTCTAGATGATGCCTTAAAACTT
ACTGAACAACCAGAATTAGCAAATAAAGTAGACATGGTCTGGATAGTTGGTGGCAGTTCT
GTTTATAAGGAAGCCATGAATCACCCAGGCCATCTTAAACTATTTGTGACAAGGATCATG
CAAGACTTTGAAAGTGACACGTTTTTTCCAGAAATTGATTTGGAGAAATATAAACTTCTG
CCAGAATACCCAGGTGTTCTCTCTGATGTCCAGGAGGAGAAAGGCATTAAGTACAAATTT
GAAGTATATGAGAAGAATGATTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
J00140

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_1_Locus:
5q11.2-q13.2

# Macromolecular_Interacting_Partner_1_SNPs:
rs1643630; rs2618372; rs1643650; rs6875184; rs10072026; rs11951910; rs836818; rs1643638; rs1677693; rs1643658; rs10078190; rs836823; rs836821; rs1643659; rs1677691; rs1643635; rs1677694; rs1677634; rs13161245; rs865646; rs1677633; rs844370; rs10052238; rs966762; rs865647; rs1650709; rs2431221; rs10054574; rs34965641; rs865645; rs1643649; rs525054; rs245104; rs11951283; rs1650700; rs1650711; rs245099; rs1650710; rs6453522; rs1677700; rs372069; rs34563643; rs1677696; rs1650714; rs1643664; rs864133; rs1623489; rs1650701; rs35709834; rs1677661; rs11742668; rs836819; rs861373; rs1677692; rs836822; rs860717; rs34781740; rs1677701; rs1650706; rs1650713; rs2560424; rs863216; rs2897261; rs1643657; rs1643661; rs1643634; rs1677666; rs12517451; rs1650723; rs12109877; rs1650720; rs14435; rs11112; rs1053136; rs11550953; rs1129240; rs1129243; rs2431220; rs7387; rs190293; rs34764978; rs35262215; rs1129242; rs34087552; rs10685456; rs1650717; rs13182730; rs1677706; rs10474631; rs34268388; rs35740086; rs6863377; rs10076523; rs2545005; rs1677704; rs1643662; rs1643647; rs1677697; rs7706270; rs10557831; rs2560423; rs3958540; rs863217; rs1677699; rs1643637; rs165957; rs3991269; rs4406117; rs34545755; rs3991268; rs245101; rs11305000; rs1643656; rs1677636; rs1677684; rs11490741; rs1650712; rs34132382; rs1677705; rs2897260; rs1677688; rs3958541; rs34289983; rs863215; rs1677686; rs1650707; rs34468903; rs1650715; rs245103; rs34184316; rs1677702; rs34288321; rs35372305; rs34122957; rs1643660; rs7705115; rs34674884; rs2434329; rs10942929; rs2927911; rs1650716; rs7706404; rs3797876; rs2405873; rs1222967; rs245105; rs1677689; rs34359040; rs11749051; rs1643648; rs2560422; rs1650718; rs1677631; rs10942928; rs34504711; rs11952744; rs3958542; rs35633165; rs1643636; rs836820; rs1650708; rs245100; rs7725721; rs34141487; rs11491447; rs1643663; rs34540063; rs8180493; rs1677687; rs1677695; rs33948142; rs1677685; rs13165178; rs10077031; rs34143020; rs390975; rs12109309; rs10168; rs10474632; rs1105524; rs1222809; rs1232027; rs1382539; rs1382540; rs1382541; rs1382542; rs1478834; rs1478835; rs1643639; rs1643641; rs1643646; rs1643655; rs1650675; rs1650676; rs1650681; rs1650692; rs1650694; rs1650695; rs1650696; rs1650697; rs1677626; rs1677667; rs1677670; rs1677682; rs1677703; rs245102; rs380691; rs3822706; rs384925; rs408626; rs442767; rs453544; rs6878815; rs6897872; rs701383; rs861365

# Macromolecular_Interacting_Partner_1_General_References:
6323448; 6687716; 6235374; 3383852; 2248959; 9374868; 1731871

# Macromolecular_Interacting_Partner_1_References:
16142999; 16280378; 16368880; 16585211

# Macromolecular_Interacting_Partner_2_ID:
7556

# Macromolecular_Interacting_Partner_2_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_2_Signals:
1-18

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_2_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_2_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_2_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_2_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_2_References:
16454580; 16468648; 16760376; 17029005

# Macromolecular_Interacting_Partner_3_ID:
7263

# Macromolecular_Interacting_Partner_3_Name:
Small inducible cytokine A2 precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
CCL2; Monocyte chemotactic protein 1; MCP-1; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte secretory protein JE; HC11

# Macromolecular_Interacting_Partner_3_Gene_Name:
CCL2

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Small inducible cytokine A2 precursor
MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCP
KEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
99

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
11025

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
9.72

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  chemokine activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00048:IL8

# Macromolecular_Interacting_Partner_3_Signals:
1-23

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
307163

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
CCL2_HUMAN (P13500)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
CCL2

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
CCL2

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:10618

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>300 bp
ATGAAAGTCTCTGCCGCCCTTCTGTGCCTGCTGCTCATAGCAGCCACCTTCATTCCCCAA
GGGCTCGCTCAGCCAGATGCAATCAATGCCCCAGTCACCTGCTGTTATAACTTCACCAAT
AGGAAGATCTCAGTGCAGAGGCTCGCGAGCTATAGAAGAATCACCAGCAGCAAGTGTCCC
AAAGAAGCTGTGATCTTCAAGACCATTGTGGCCAAGGAGATCTGTGCTGACCCCAAGCAG
AAGTGGGTTCAGGATTCCATGGACCACCTGGACAAGCAAACCCAAACTCCGAAGACTTGA


# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
M24545

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_3_Locus:
17q11.2-q12

# Macromolecular_Interacting_Partner_3_SNPs:
rs4586; rs13900; rs2215182; rs2857657; rs3917887; rs28730833; rs2857656; rs2190971; rs2857655; rs3760399; rs3091332; rs3917886; rs11575012; rs11575011; rs3760396; rs13306749; rs13306748; rs13306750; rs41507946; rs3917888; rs34095515; rs3760398; rs11575010; rs2190972; rs36231142; rs3917904; rs1014542; rs3760397; rs1024610; rs1024611; rs1080327; rs11575013; rs11575018; rs11652475; rs11652585; rs11655761; rs11656026; rs11656271; rs11867200; rs11870347; rs17652343; rs1860188; rs1860189; rs1860190; rs1989055; rs2530797; rs2857653; rs2857654; rs3091315; rs3091316; rs3917878; rs3917883; rs3917891; rs3917894; rs3917895; rs4795893; rs4795894; rs6505402; rs7210316; rs7503519; rs8068314; rs8074043; rs8079288; rs991804

# Macromolecular_Interacting_Partner_3_General_References:
2923622; 2513477; 2465924; 2518726; 2357211; 1661560; 8107690; 10918580; 2648385; 2322286; 2071154; 8195247; 8627182; 8898111; 1857712; 8639605; 8989326

# Macromolecular_Interacting_Partner_3_References:
16178442; 16491109

# Macromolecular_Interacting_Partner_4_ID:
7252

# Macromolecular_Interacting_Partner_4_Name:
Multidrug resistance-associated protein 1

# Macromolecular_Interacting_Partner_4_Synonyms:
ATP-binding cassette sub- family C member 1; Leukotriene C(4transporter; LTC4 transporter

# Macromolecular_Interacting_Partner_4_Gene_Name:
ABCC1

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Multidrug resistanceassociated protein 1
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITTLLA
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND
SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLAR
AVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIV
MSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGM
LVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL
SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG
ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL
DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL
KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA
VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA
VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG
EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF
SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCL
ARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVL
DKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
1531

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
171563

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
7.11

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  transporter activity
Function:  ATPase activity
Function:  hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Function:  ATPase activity, coupled to transmembrane movement of substances
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_4_Specific_Function:
May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Confers resistance to anticancer drugs. Transports LTC4. May protect milk against xenobiotics

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00664:ABC_membrane;
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
34-54
75-95
101-121
134-154
173-193
317-337
364-384
441-461
465-485
548-568
591-611
968-988
1026-1046
1090-1110
1112-1132
1204-1224
1227-1247

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
1835659

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
MRP1_HUMAN (P33527)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
ABCC1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
ABCC1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:51

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>4596 bp
ATGGCGCTCCGGGGCTTCTGCAGCGCCGATGGCTCCGACCCGCTCTGGGACTGGAATGTC
ACGTGGAATACCAGCAACCCCGACTTCACCAAGTGCTTTCAGAACACGGTCCTCGTGTGG
GTGCCTTGTTTTTACCTCTGGGCCTGTTTCCCCTTCTACTTCCTCTATCTCTCCCGACAT
GACCGAGGCTACATTCAGATGACACCTCTCAACAAAACCAAAACTGCCTTGGGATTTTTG
CTGTGGATCGTCTGCTGGGCAGACCTCTTCTACTCTTTCTGGGAAAGAAGTCGGGGCATA
TTCCTGGCCCCAGTGTTTCTGGTCAGCCCAACTCTCTTGGGCATCACCACGCTGCTTGCT
ACCTTTTTAATTCAGCTGGAGAGGAGGAAGGGAGTTCAGTCTTCAGGGATCATGCTCACT
TTCTGGCTGGTAGCCCTAGTGTGTGCCCTAGCCATCCTGAGATCCAAAATTATGACAGCC
TTAAAAGAGGATGCCCAGGTGGACCTGTTTCGTGACATCACTTTCTACGTCTACTTTTCC
CTCTTACTCATTCAGCTCGTCTTGTCCTGTTTCTCAGATCGCTCACCCCTGTTCTCGGAA
ACCATCCACGACCCTAATCCCTGCCCAGAGTCCAGCGCTTCCTTCCTGTCGAGGATCACC
TTCTGGTGGATCACAGGGTTGATTGTCCGGGGCTACCGCCAGCCCCTGGAGGGCAGTGAC
CTCTGGTCCTTAAACAAGGAGGACACGTCGGAACAAGTCGTGCCTGTTTTGGTAAAGAAC
TGGAAGAAGGAATGCGCCAAGACTAGGAAGCAGCCGGTGAAGGTTGTGTACTCCTCCAAG
GATCCTGCCCAGCCGAAAGAGAGTTCCAAGGTGGATGCGAATGAGGAGGTGGAGGCTTTG
ATCGTCAAGTCCCCACAGAAGGAGTGGAACCCCTCTCTGTTTAAGGTGTTATACAAGACC
TTTGGGCCCTACTTCCTCATGAGCTTCTTCTTCAAGGCCATCCACGACCTGATGATGTTT
TCCGGGCCGCAGATCTTAAAGTTGCTCATCAAGTTCGTGAATGACACGAAGGCCCCAGAC
TGGCAGGGCTACTTCTACACCGTGCTGCTGTTTGTCACTGCCTGCCTGCAGACCCTCGTG
CTGCACCAGTACTTCCACATCTGCTTCGTCAGTGGCATGAGGATCAAGACCGCTGTCATT
GGGGCTGTCTATCGGAAGGCCCTGGTGATCACCAATTCAGCCAGAAAATCCTCCACGGTC
GGGGAGATTGTCAACCTCATGTCTGTGGACGCTCAGAGGTTCATGGACTTGGCCACGTAC
ATTAACATGATCTGGTCAGCCCCCCTGCAAGTCATCCTTGCTCTCTACCTCCTGTGGCTG
AATCTGGGCCCTTCCGTCCTGGCTGGAGTGGCGGTGATGGTCCTCATGGTGCCCGTCAAT
GCTGTGATGGCGATGAAGACCAAGACGTATCAGGTGGCCCACATGAAGAGCAAAGACAAT
CGGATCAAGCTGATGAACGAAATTCTCAATGGGATCAAAGTGCTAAAGCTTTATGCCTGG
GAGCTGGCATTCAAGGACAAGGTGCTGGCCATCAGGCAGGAGGAGCTGAAGGTGCTGAAG
AAGTCTGCCTACCTGTCAGCCGTGGGCACCTTCACCTGGGTCTGCACGCCCTTTCTGGTG
GCCTTGTGCACATTTGCCGTCTACGTGACCATTGACGAGAACAACATCCTGGATGCCCAG
ACAGCCTTCGTGTCTTTGGCCTTGTTCAACATCCTCCGGTTTCCCCTGAACATTCTCCCC
ATGGTCATCAGCAGCATCGTGCAGGCGAGTGTCTCCCTCAAACGCCTGAGGATCTTTCTC
TCCCATGAGGAGCTGGAACCTGACAGCATCGAGCGACGGCCTGTCAAAGACGGCGGGGGC
ACGAACAGCATCACCGTGAGGAATGCCACATTCACCTGGGCCAGGAGCGACCCTCCCACA
CTGAATGGCATCACCTTCTCCATCCCCGAAGGTGCTTTGGTGGCCGTGGTGGGCCAGGTG
GGCTGCGGAAAGTCGTCCCTGCTCTCAGCCCTCTTGGCTGAGATGGACAAAGTGGAGGGG
CACGTGGCTATCAAGGGCTCCGTGGCCTATGTGCCACAGCAGGCCTGGATTCAGAATGAT
TCTCTCCGAGAAAACATCCTTTTTGGATGTCAGCTGGAGGAACCATATTACAGGTCCGTG
ATACAGGCCTGTGCCCTCCTCCCAGACCTGGAAATCCTGCCCAGTGGGGATCGGACAGAG
ATTGGCGAGAAGGGCGTGAACCTGTCTGGGGGCCAGAAGCAGCGCGTGAGCCTGGCCCGG
GCCGTGTACTCCAACGCTGACATTTACCTCTTCGATGATCCCCTCTCAGCAGTGGATGCC
CATGTGGGAAAACACATCTTTGAAAATGTGATTGGCCCCAAGGGGATGCTGAAGAACAAG
ACGCGGATCTTGGTCACGCACAGCATGAGCTACTTGCCGCAGGTGGACGTCATCATCGTC
ATGAGTGGCGGCAAGATCTCTGAGATGGGCTCCTACCAGGAGCTGCTGGCTCGAGACGGC
GCCTTCGCTGAGTTCCTGCGTACCTATGCCAGCACAGAGCAGGAGCAGGATGCAGAGGAG
AACGGGGTCACGGGCGTCAGCGGTCCAGGGAAGGAAGCAAAGCAAATGGAGAATGGCATG
CTGGTGACGGACAGTGCAGGGAAGCAACTGCAGAGACAGCTCAGCAGCTCCTCCTCCTAT
AGTGGGGACATCAGCAGGCACCACAACAGCACCGCAGAACTGCAGAAAGCTGAGGCCAAG
AAGGAGGAGACCTGGAAGCTGATGGAGGCTGACAAGGCGCAGACAGGGCAGGTCAAGCTT
TCCGTGTACTGGGACTACATGAAGGCCATCGGACTCTTCATCTCCTTCCTCAGCATCTTC
CTTTTCATGTGTAACCATGTGTCCGCGCTGGCTTCCAACTATTGGCTCAGCCTCTGGACT
GATGACCCCATCGTCAACGGGACTCAGGAGCACACGAAAGTCCGGCTGAGCGTCTATGGA
GCCCTGGGCATTTCACAAGGGATCGCCGTGTTTGGCTACTCCATGGCCGTGTCCATCGGG
GGGATCTTGGCTTCCCGCTGTCTGCACGTGGACCTGCTGCACAGCATCCTGCGGTCACCC
ATGAGCTTCTTTGAGCGGACCCCCAGTGGGAACCTGGTGAACCGCTTCTCCAAGGAGCTG
GACACAGTGGACTCCATGATCCCGGAGGTCATCAAGATGTTCATGGGCTCCCTGTTCAAC
GTCATTGGTGCCTGCATCGTTATCCTGCTGGCCACGCCCATCGCCGCCATCATCATCCCG
CCCCTTGGCCTCATCTACTTCTTCGTCCAGAGGTTCTACGTGGCTTCCTCCCGGCAGCTG
AAGCGCCTCGAGTCGGTCAGCCGCTCCCCGGTCTATTCCCATTTCAACGAGACCTTGCTG
GGGGTCAGCGTCATTCGAGCCTTCGAGGAGCAGGAGCGCTTCATCCACCAGAGTGACCTG
AAGGTGGACGAGAACCAGAAGGCCTATTACCCCAGCATCGTGGCCAACAGGTGGCTGGCC
GTGCGGCTGGAGTGTGTGGGCAACTGCATCGTTCTGTTTGCTGCCCTGTTTGCGGTGATC
TCCAGGCACAGCCTCAGTGCTGGCTTGGTGGGCCTCTCAGTGTCTTACTCATTGCAGGTC
ACCACGTACTTGAACTGGCTGGTTCGGATGTCATCTGAAATGGAAACCAACATCGTGGCC
GTGGAGAGGCTCAAGGAGTATTCAGAGACTGAGAAGGAGGCGCCCTGGCAAATCCAGGAG
ACAGCTCCGCCCAGCAGCTGGCCCCAGGTGGGCCGAGTGGAATTCCGGAACTACTGCCTG
CGCTACCGAGAGGACCTGGACTTCGTTCTCAGGCACATCAATGTCACGATCAATGGGGGA
GAAAAGGTCGGCATCGTGGGGCGGACGGGAGCTGGGAAGTCGTCCCTGACCCTGGGCTTA
TTTCGGATCAACGAGTCTGCCGAAGGAGAGATCATCATCGATGGCATCAACATCGCCAAG
ATCGGCCTGCACGACCTCCGCTTCAAGATCACCATCATCCCCCAGGACCCTGTTTTGTTT
TCGGGTTCCCTCCGAATGAACCTGGACCCATTCAGCCAGTACTCGGATGAAGAAGTCTGG
ACGTCCCTGGAGCTGGCCCACCTGAAGGACTTCGTGTCAGCCCTTCCTGACAAGCTAGAC
CATGAATGTGCAGAAGGCGGGGAGAACCTCAGTGTCGGGCAGCGCCAGCTTGTGTGCCTA
GCCCGGGCCCTGCTGAGGAAGACGAAGATCCTTGTGTTGGATGAGGCCACGGCAGCCGTG
GACCTGGAAACGGACGACCTCATCCAGTCCACCATCCGGACACAGTTCGAGGACTGCACC
GTCCTCACCATCGCCCACCGGCTCAACACCATCATGGACTACACAAGGGTGATCGTCTTG
GACAAAGGAGAAATCCAGGAGTACGGCGCCCCATCGGACCTCCTGCAGCAGAGAGGTCTT
TTCTACAGCATGGCCAAAGACGCCGGCTTGGTGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
L05628

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_4_Locus:
16p13.1

# Macromolecular_Interacting_Partner_4_SNPs:
rs13337489; rs246221; rs8187863; rs35605; rs2301666; rs9933640; rs35587; rs8187853; rs2239330; rs8187858; rs16967004; rs212090; rs129081; rs3743527; rs2644983; rs215101; rs246240; rs35592; rs152022; rs152029; rs215059; rs2014800; rs903880; rs35591; rs1967120; rs246217; rs2283515; rs937369; rs215074; rs2239996; rs246220; rs129116; rs212081; rs35628; rs35597; rs875740; rs35604; rs2062541; rs215063; rs212082; rs212087; rs215094; rs246232; rs8050836; rs4148333; rs117854; rs246230; rs246228; rs212085; rs246234; rs215100; rs1964656; rs35588; rs11864374; rs4781711; rs3851710; rs11861115; rs7188722; rs35621; rs4780585; rs35607; rs4148366; rs9932506; rs7189813; rs11075296; rs212084; rs171583; rs924138; rs35589; rs7198841; rs2238475; rs7188937; rs246214; rs119774; rs6498594; rs8052419; rs215075; rs4148355; rs212089; rs3851718; rs215049; rs9933511; rs4781708; rs7187319; rs173476; rs35595; rs3887893; rs215105; rs35610; rs2889517; rs152030; rs7190484; rs8054670; rs3851712; rs35623; rs246226; rs7204081; rs11861085; rs9332430; rs4148343; rs3784867; rs246215; rs35596; rs215099; rs185005; rs8048316; rs2269800; rs8061136; rs7185286; rs215052; rs246219; rs2074086; rs4781712; rs246212; rs3851711; rs8059648; rs35620; rs11075293; rs193538; rs8054156; rs3784864; rs35629; rs3887412; rs3851719; rs6498591; rs11642957; rs246238; rs2384938; rs215098; rs12923345; rs8045309; rs1964657; rs16967126; rs3784862; rs12921748; rs246218; rs246222; rs215077; rs12934692; rs7404127; rs7188177; rs6498595; rs12445600; rs2283512; rs17501011; rs152032; rs4780589; rs8044115; rs17287570; rs215087; rs4148354; rs35625; rs9673292; rs17215768; rs35618; rs35594; rs2283516; rs17205859; rs11865361; rs4781699; rs7198766; rs452277; rs215088; rs246235; rs2384939; rs4780592; rs9932856; rs8047359; rs40427; rs35615; rs152027; rs215058; rs17501331; rs16967173; rs924135; rs6498597; rs35626; rs9932395; rs8049010; rs9932097; rs8053266; rs11861014; rs215096; rs8051963; rs17579406; rs2889518; rs11075291; rs4781727; rs35619; rs4780591; rs6498590; rs9635480; rs35606; rs152033; rs1153867; rs2074087; rs35601; rs152260; rs4781724; rs12921924; rs11075292; rs7203145; rs7196296; rs2238474; rs8048428; rs8054099; rs6498593; rs16967758; rs16967096; rs17265551; rs4781718; rs4148361; rs11861804; rs3851717; rs8058379; rs246241; rs11865571; rs16967145; rs215085; rs11866794; rs215066; rs1874001; rs16967227; rs11647513; rs7198932; rs903881; rs17264736; rs4148358; rs7189529; rs10852377; rs35627; rs11862504; rs2299670; rs182482; rs12924212; rs6498592; rs11075290; rs152028; rs152031; rs9938317; rs165975; rs8050637; rs7202970; rs12444264; rs4781716; rs7195031; rs12708802; rs2074085; rs215090; rs7197317; rs246236; rs11075289; rs35612; rs4148344; rs3851713; rs7201642; rs4780593; rs13332486; rs17579503; rs12921623; rs3888565; rs8187860; rs16967755; rs3765129; rs215086; rs4781701; rs924137; rs7196970; rs8048485; rs7201361; rs35614; rs7200100; rs3819552; rs12449241; rs6416665; rs11075295; rs11860247; rs35599; rs3216337; rs13335850; rs152023; rs35622; rs4148353; rs11861765; rs2644990; rs4148375; rs3844217; rs12922744; rs8055903; rs11645172; rs9923585; rs215091; rs7199424; rs215095; rs7193363; rs246229; rs7189316; rs11862407; rs9927099; rs4781709; rs12596469; rs215076; rs7196112; rs3851708; rs193537; rs7197383; rs16967179; rs9933152; rs9921168; rs16967046; rs3837750; rs3851716; rs248417; rs762775; rs1809815; rs4781700; rs12447386; rs215106; rs8056499; rs16955252; rs215053; rs8057422; rs215064; rs6498598; rs4781715; rs4148337; rs149541; rs4148346; rs762778; rs3784863; rs4148376; rs169984; rs11645782; rs2270490; rs12924026; rs7198391; rs8055510; rs17205838; rs215050; rs8058078; rs12927980; rs35602; rs11640751; rs246233; rs4781710; rs3888568; rs246223; rs456640; rs9931401; rs11075297; rs4148331; rs3851715; rs13331142; rs8059482; rs9927011; rs458926; rs8057596; rs12930197; rs215061; rs11866350; rs12929789; rs4148340; rs215054; rs3851709; rs215092; rs9933592; rs4781714; rs12922588; rs11863132; rs12447005; rs762777; rs11075288; rs35593; rs17841264; rs215079; rs4148351; rs152024; rs246213; rs215067; rs4148373; rs997691; rs215062; rs215051; rs215060; rs12927675; rs7198872; rs11861837; rs9928852; rs35616; rs4148335; rs13339242; rs9938526; rs10775291; rs215072; rs215089; rs35624; rs9931103; rs8057590; rs4781721; rs17205398; rs212079; rs8047227; rs7192281; rs8063599; rs215108; rs150530; rs4781720; rs1472532; rs35611; rs3932161; rs12446785; rs12922404; rs215055; rs8047871; rs215078; rs4781717; rs11865161; rs7193261; rs2283514; rs212083; rs169985; rs6498596; rs215103; rs246227; rs215057; rs17287542; rs4780586; rs937367; rs3784860; rs8062525; rs3851714; rs8058040; rs8059503; rs9934297; rs212088; rs13332140; rs35609; rs8047230; rs215068; rs212086; rs12599429; rs16966996; rs6498599; rs4780584; rs7198319; rs8046737; rs7186901; rs8053946; rs13335227; rs2644989; rs152025; rs35613; rs2283511; rs8046950; rs35600; rs4238623; rs4781722; rs4148362; rs11075298; rs13336889; rs4148336; rs12935283; rs215097; rs246237; rs924136; rs215056; rs4148349; rs11865349; rs35598; rs12449239; rs5016527; rs16967135; rs212080; rs8060750; rs2239995; rs4148359; rs215073; rs12447187; rs35590; rs6416666; rs7498870; rs9935678; rs12928602; rs7195815; rs3784861; rs10852378; rs7195962; rs11640684; rs9673916; rs35608; rs2238476; rs13333810; rs212091; rs4148380; rs504348; rs4148330; rs8056298; rs41395947; rs41410450; rs8057331; rs4148356; rs28706727; rs41494447; rs4148377; rs12596095; rs35840440; rs11647037; rs435683; rs7202416; rs36027088; rs2047591; rs8047497; rs28535049; rs36032323; rs35752420; rs7187052; rs3072717; rs28431874; rs34993915; rs34549440; rs12927511; rs34833276; rs12917894; rs13337533; rs35358180; rs10638507; rs9935219; rs35705679; rs10614463; rs9927479; rs4148363; rs13333388; rs7501384; rs4148371; rs4781728; rs12920011; rs35727154; rs11860365; rs28377922; rs12934657; rs35006643; rs28814960; rs12920817; rs5815853; rs215070; rs215065; rs35874442; rs5815856; rs11393636; rs10543560; rs33981753; rs35046517; rs4780588; rs5815852; rs34673924; rs35160852; rs6498601; rs28852806; rs34873364; rs4781707; rs10644540; rs9929609; rs13332722; rs2376956; rs34220492; rs35240096; rs28600754; rs11397057; rs3837749; rs4148368; rs12926867; rs12934266; rs9932205; rs35418200; rs35711628; rs12921067; rs35240251; rs28489119; rs13339669; rs35076831; rs13332852; rs165974; rs35241718; rs10438544; rs34334712; rs215080; rs13337581; rs34184710; rs12923217; rs35662370; rs34417580; rs28502346; rs11866942; rs11647533; rs28844882; rs34365293; rs8054963; rs10636969; rs9940699; rs393915; rs4479256; rs8055122; rs41278166; rs12920754; rs35229595; rs34555174; rs1108573; rs215109; rs13334390; rs12918259; rs34155371; rs35666498; rs11862552; rs10634703; rs11643934; rs34712007; rs4148364; rs12928233; rs11287273; rs12924449; rs12926589; rs10577554; rs11441919; rs10526186; rs7498869; rs35219631; rs34044736; rs12923333; rs35081755; rs34550012; rs35201502; rs10591001; rs215104; rs34485846; rs150529; rs4781719; rs11441920; rs7404359; rs12920923; rs35208396; rs9936158; rs11282335; rs34528514; rs34905861; rs2385154; rs35207136; rs5815854; rs35096356; rs35694522; rs4148369; rs7205368; rs10543561; rs35804420; rs7188711; rs35978240; rs28661219; rs11410221; rs8058069; rs7195265; rs9922649; rs35600720; rs12927259; rs246225; rs34275813; rs3837751; rs10712722; rs28662320; rs1690409; rs35090860; rs4646414; rs9933212; rs34159339; rs12447413; rs28710234; rs1690410; rs12935384; rs4148360; rs10694441; rs34530270; rs11373213; rs12443966; rs10656206; rs28393114; rs3072761; rs10673887; rs34085651; rs11427239; rs8062040; rs215048; rs34026115; rs9936155; rs33916796; rs35534532; rs5815850; rs34627014; rs34325137; rs11311843; rs34655471; rs34914361; rs34817873; rs35167276; rs11274450; rs4148350; rs11380982; rs34820524; rs34761300; rs35092337; rs410375; rs35694269; rs34630818; rs28753779; rs35490080; rs34313407; rs7192604; rs35086205; rs11277270; rs12933642; rs12925569; rs371941; rs35246390; rs12929025; rs35151447; rs35928400; rs35167165; rs28505554; rs35327998; rs5815857; rs34346901; rs7194547; rs36108316; rs11317464; rs34600200; rs34770208; rs246224; rs10673886; rs34123416; rs34383577; rs7498133; rs3851720; rs12934619; rs7193196; rs35525424; rs8062912; rs34982921; rs10555145; rs35254618; rs35193854; rs4115669; rs12926865; rs11640365; rs3080589; rs34334486; rs5815858; rs34479623; rs11325281; rs35126918; rs35367430; rs34868583; rs3072678; rs34536387; rs34557574; rs215069; rs12920474; rs12919829; rs34358165; rs28695591; rs9932986; rs34292006; rs35704526; rs35802304; rs35378917; rs34575102; rs12934210; rs12149248; rs246239; rs3072682; rs34897139; rs149320; rs34115753; rs7192845; rs4148347; rs9674124; rs8057769; rs11371659; rs35347382; rs11284065; rs8050655; rs34443742; rs17289179; rs12918323; rs35810367; rs11269394; rs35419413; rs35420214; rs34650655; rs35956116; rs34936105; rs35600994; rs6416667; rs12929024; rs12934905; rs17289158; rs28722680; rs2014793; rs1153866; rs12449077; rs34752935; rs3743526; rs35747063; rs34872698; rs8044628; rs35437608; rs11644918; rs4148348; rs12596360; rs35058919; rs4148332; rs34654774; rs41280868; rs10589853; rs36056963; rs10580146; rs11642737; rs10716039; rs7193755; rs152261; rs4520863; rs35609874; rs35869759; rs13329759; rs35851401; rs34074243; rs34575460; rs4148370; rs34490863; rs10532060; rs13334396; rs11327128; rs11343915; rs34482500; rs12917903; rs12934085; rs34466025; rs11639546; rs28592191; rs3830390; rs9923248; rs1690411; rs35471843; rs4780590; rs16967727; rs34789916; rs35133979; rs12934491; rs1874473; rs35983738; rs35101141; rs35252822; rs2283513; rs28501979; rs9889088; rs9929703; rs11323592; rs34788606; rs4459564; rs35384983; rs7193245; rs12934472; rs4646415; rs35685006; rs12927524; rs34005060; rs9931487; rs28515006; rs11647389; rs12050956; rs35692393; rs34742430; rs35708071; rs762776; rs13337279; rs5815855; rs34781067; rs35494993; rs35163690; rs41278168; rs12929883; rs13380679; rs7194549; rs35273939; rs12933311; rs28723466; rs490294; rs10706261; rs35493923; rs2384937; rs36080634; rs34754847; rs28561819; rs35605618; rs215102; rs7193525; rs34024385; rs4780594; rs28367505; rs11863228; rs13332325; rs11281850; rs12934805; rs8045000; rs4148367; rs5815851; rs6145768; rs10568708; rs35617; rs11644882; rs7202715; rs34870561; rs10673197; rs11320744; rs35791790; rs7196697; rs4497718; rs4148342; rs11416711; rs35962196; rs11304106; rs34692171; rs34935265; rs10598360; rs28735920; rs35603; rs6498600; rs215107; rs11416710; rs34985714; rs12925671; rs34292394; rs3072683; rs1697157; rs7205077; rs8064014; rs34714018; rs35601346; rs8058245; rs12232450; rs7199834; rs35481775; rs11430158; rs11291616; rs12930255; rs7197454; rs215093; rs28435381; rs34360190; rs8058920; rs4148378; rs28450757; rs35473382; rs4780587; rs10648689; rs416821; rs35118593; rs979560; rs34692126; rs7404210; rs11399369; rs12917672; rs4148365; rs34233722; rs28449253; rs34088403; rs34566056; rs11449114; rs35335689; rs34381428; rs34089889; rs12929977; rs11075299; rs12448760; rs16967632; rs212093; rs212094; rs212097; rs212098; rs2238473; rs28364001; rs28364002; rs34288338; rs34526519; rs34545444; rs35148086; rs35934123; rs35939983; rs3902401; rs4148382; rs6498603; rs7192634; rs8047642; rs8050881; rs8062278; rs8187843; rs8187844; rs8187845; rs8187846; rs8187848; rs8187849; rs8187850; rs8187851; rs8187854; rs8187855; rs8187856; rs8187857; rs8187859; rs8187861; rs8187862

# Macromolecular_Interacting_Partner_4_General_References:
1360704; 8098549; 8649356; 9344662; 10493829; 9295302; 9334225; 9485377; 11114332; 11469806; 11278867; 10835642; 10811882; 11721885; 11139250; 11266082

# Macromolecular_Interacting_Partner_4_References:
16362298; 16504991

# Macromolecular_Interacting_Partner_5_ID:
6072

# Macromolecular_Interacting_Partner_5_Name:
Serine hydroxymethyltransferase, mitochondrial precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
Serine methylase; Glycine hydroxymethyltransferase; SHMT

# Macromolecular_Interacting_Partner_5_Gene_Name:
SHMT2

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Serine hydroxymethyltransferase, mitochondrial precursor
MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELL
QREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQ
RRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV
KRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREV
CDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVD
PKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARA
MADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAIT
PGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQ
RLANLRQRVEQFARAFPMPGFDEH

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
504

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
55994

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
8.67

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  glycine hydroxymethyltransferase activity
 ||
>>>
Process:  L-serine metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_5_Specific_Function:
Interconversion of serine and glycine

# Macromolecular_Interacting_Partner_5_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00310  Lysine degradation;
 map00460  Cyanoamino acid metabolism;
 map00670  One carbon pool by folate;
 map00680  Methane metabolism

# Macromolecular_Interacting_Partner_5_Reaction:
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00464:SHMT

# Macromolecular_Interacting_Partner_5_Signals:
1-18

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
EC 2.1.2.1

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
746436

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
GLYM_HUMAN (P34897)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
SHMT2

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
SHMT2

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:10852

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Mitochondrion

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1452 bp
ATGGCCATTCGGGCTCAGCACAGCAACGCAGCCCAGACTCAGACTGGGGAAGCAAACAGG
GGCTGGACAGGCCAGGAGAGCCTGTCGGACAGTGATCCTGAGATGTGGGAGTTGCTGCAG
AGGGAGAAGGACAGGCAGTGTCGTGGCCTGGAGCTCATTGCCTCAGAGAACTTCTGCAGC
CGAGCTGCGCTGGAGGCCCTGGGGTCCTGTCTGAACAACAAGTACTCGGAGGGTTATCCT
GGCAAGAGATACTATGGGGGAGCAGAGGTGGTGGATGAAATTGAGCTGCTGTGCCAGCGC
CGGGCCTTGGAAGCCTTTGACCTGGATCCTGCACAGTGGGGAGTCAATGTCCAGCCCTAC
TCCGGGTCCCCAGCCAACCTGGCCGTCTACACAGCCCTTCTGCAACCTCACGACCGGATC
ATGGGGCTGGACCTGCCCGATGGGGGCCATCTCACCCACGGCTACATGTCTGACGTCAAG
CGGATATCAGCCACGTCCATCTTCTTCGAGTCTATGCCCTATAAGCTCAACCCCAAAACT
GGCCTCATTGACTACAACCAGCTGGCACTGACTGCTCGACTTTTCCGGCCACGGCTCATC
ATAGCTGGCACCAGCGCCTATGCTCGCCTCATTGACTACGCCCGCATGAGAGAGGTGTGT
GATGAAGTCAAAGCACACCTGCTGGCAGACATGGCCCACATCAGTGGCCTGGTGGCTGCC
AAGGTGATTCCCTCGCCTTTCAAGCACGCGGACATCGTCACCACCACTACTCACAAGACT
CTTCGAGGGGCCAGGTCAGGGCTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGGACCCC
AAGACTGGCCGGGAGATCCCTTACACATTTGAGGACCGAATCAACTTTGCCGTGTTCCCA
TCCCTGCAGGGGGGCCCCCACAATCATGCCATTGCTGCAGTAGCTGTGGCCCTAAAGCAG
GCCTGCACCCCCATGTTCCGGGAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGGCCATG
GCAGATGCCCTGCTAGAGCGAGGCTACTCACTGGTATCAGGTGGTACTGACAACCACCTG
GTGCTGGTGGACCTGCGGCCCAAGGGCCTGGATGGAGCTCGGGCTGAGCGGGTGCTAGAG
CTTGTATCCATCACTGCCAACAAGAACACCTGTCCTGGAGACCGAAGTGCCATCACACCG
GGCGGCCTGCGGCTTGGGGCCCCAGCCTTAACTTCTCGACAGTTCCGTGAGGATGACTTC
CGGAGAGTTGTGGACTTTATAGATGAAGGGGTCAACATTGGCTTAGAGGTGAAGAGCAAG
ACTGCCAAGCTCCAGGATTTCAAATCCTTCCTGCTTAAGGACTCAGAAACAAGTCAGCGT
CTGGCCAACCTCAGGCAACGGGTGGAGCAGTTTGCCAGGGCCTTCCCCATGCCTGGTTTT
GATGAGCATTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
U23143

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_5_Locus:
12q12-q14

# Macromolecular_Interacting_Partner_5_SNPs:
rs2229717; rs2229718; rs2229716; rs11615783; rs28365862; rs28365863; rs7301155; rs12319666; rs11557165; rs11557163; rs11557167; rs11557162; rs14201; rs2229715; rs11557166; rs10603176; rs28365864; rs34095989; rs34808817; rs35850385; rs35467141; rs12826178; rs10717122; rs35603162; rs10783815; rs11609986; rs11612037; rs11612551; rs11829843; rs3204635; rs35132254; rs6581130; rs7134826; rs7485577

# Macromolecular_Interacting_Partner_5_General_References:
8999870; 8505317; 10828359

# Macromolecular_Interacting_Partner_5_References:
16876889

# Macromolecular_Interacting_Partner_6_ID:
6130

# Macromolecular_Interacting_Partner_6_Name:
Folylpolyglutamate synthase, mitochondrial precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolate synthase; Tetrahydrofolylpolyglutamate synthase

# Macromolecular_Interacting_Partner_6_Gene_Name:
FPGS

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Folylpolyglutamate synthase, mitochondrial precursor
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
HQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
QASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSP
PKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
587

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
64610

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
8.00

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  acid-amino acid ligase activity
Function:  tetrahydrofolylpolyglutamate synthase activity
 ||
>>>
Process:  biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  aromatic compound metabolism
Process:  folic acid and derivative metabolism
Process:  folic acid and derivative biosynthesis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Coenzyme transport and metabolism 

# Macromolecular_Interacting_Partner_6_Specific_Function:
Conversion of folates to polyglutamate derivatives. This allows tissues to concentrate folate at higher levels than in plasma

# Macromolecular_Interacting_Partner_6_Pathway:
map00790  Folate biosynthesis

# Macromolecular_Interacting_Partner_6_Reaction:
ATP + tetrahydrofolyl-[Glu]n + L-glutamate = ADP + phosphate + tetrahydrofolyl-[Glu]n+1

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF02875:Mur_ligase_C

# Macromolecular_Interacting_Partner_6_Signals:
1-19

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
EC 6.3.2.17

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
292029

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
FOLC_HUMAN (Q05932)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
FPGS

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
FPGS

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:3824

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Mitochondrion. Cytoplasm

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1638 bp
ATGGAGTACCAGGATGCCGTGCGCATGCTCAATACCCTGCAGACCAATGCCGGCTACCTG
GAGCAGGTGAAGCGCCAGCGGGGTGACCCTCAGACACAGTTGGAAGCCATGGAACTGTAC
CTGGCACGGAGTGGGCTGCAGGTGGAGGACTTGGACCGGCTGAACATCATCCACGTCACT
GGGACGAAGGGGAAGGGCTCCACCTGTGCCTTCACGGAATGTATCCTCCGAAGCTATGGC
CTGAAGACGGGATTCTTTAGCTCTCCCCACCTGGTGCAGGTTCGGGAGCGGATCCGCATC
AATGGGCAGCCCATCAGTCCTGAGCTCTTCACCAAGTACTTCTGGCGCCTCTACCACCGG
CTGGAGGAGACCAAGGATGGCAGCTGTGTCTCCATGCCCCCCTACTTCCGCTTCCTGACA
CTCATGGCCTTCCACGTCTTCCTCCAAGAGAAGGTGGACCTGGCAGTGGTGGAGGTGGGC
ATTGGCGGGGCTTATGACTGCACCAACATCATCAGGAAGCCTGTGGTGTGCGGAGTCTCC
TCTCTTGGCATCGACCACACCAGCCTCCTGGGGGATACGGTGGAGAAGATCGCATGGCAG
AAAGGGGGCATCTTTAAGCAAGGTGTCCCTGCCTTCACTGTGCTCCAACCTGAAGGTCCC
CTGGCAGTGCTGAGGGACCGAGCCCAGCAGATCTCATGTCCTCTATACCTGTGTCCGATG
CTGGAGGCCCTCGAGGAAGGGGGGCCGCCGCTGACCCTGGGCCTGGAGGGGGAGCACCAG
CGGTCCAACGCCGCCTTGGCCTTGCAGCTGGCCCACTGCTGGCTGCAGCGGCAGGACCGC
CATGGTGCTGGGGAGCCAAAGGCATCCAGGCCAGGGCTCCTGTGGCAGCTGCCCCTGGCA
CCTGTGTTCCAGCCCACATCCCACATGCGGCTCGGGCTTCGGAACACGGAGTGGCCGGGC
CGGACGCAGGTGCTGCGGCGCGGGCCCCTCACCTGGTACCTGGACGGTGCGCACACCGCC
AGCAGCGCGCAGGCCTGCGTGCGCTGGTTCCGCCAGGCGCTGCAGGGCCGCGAGAGGCCG
AGCGGTGGCCCCGAGGTTCGAGTCTTGCTCTTCAATGCTACCGGGGACCGGGACCCGGCG
GCCCTGCTGAAGCTGCTGCAGCCCTGCCAGTTTGACTATGCCGTCTTCTGCCCTAACCTG
ACAGAGGTGTCATCCACAGGCAACGCAGACCAACAGAACTTCACAGTGACACTGGACCAG
GTCCTGCTCCGCTGCCTGGAACACCAGCAGCACTGGAACCACCTGGACGAAGAGCAGGCC
AGCCCGGACCTCTGGAGTGCCCCCAGCCCAGAGCCCGGTGGGTCCGCATCCCTGCTTCTG
GCGCCCCACCCACCCCACACCTGCAGTGCCAGCTCCCTCGTCTTCAGCTGCATTTCACAT
GCCTTGCAATGGATCAGCCAAGGCCGAGACCCCATCTTCCAGCCACCTAGTCCCCCAAAG
GGCCTCCTCACCCACCCTGTGGCTCACAGTGGGGCCAGCATACTCCGTGAGGCTGCTGCC
ATCCATGTGCTAGTCACTGGCAGCCTGCACCTGGTGGGTGGTGTCCTGAAGCTGCTGGAG
CCCGCACTGTCCCAGTAG

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
M98045

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_6_Locus:
9q34.1

# Macromolecular_Interacting_Partner_6_SNPs:
rs10760502; rs34354111; rs7856096; rs10106; rs955171; rs1042304; rs7027767; rs7868117; rs1966227; rs4451422; rs12005665; rs10732395; rs28570299; rs11790075; rs17855900; rs12686275; rs2230270; rs41306702; rs35789560; rs34330923; rs11554717; rs1042320; rs2183471; rs10120483; rs10987742; rs41307463; rs10122277; rs7854264; rs34756461; rs10987745; rs34570466; rs10987744; rs3926812; rs5900768; rs10819307; rs12004468; rs35024559; rs35879553; rs7847684; rs10122348; rs35214573; rs10987743; rs10671024; rs9632913; rs35903231; rs35342422; rs10122345; rs9802255; rs11414140; rs10987741; rs36204713; rs36204705; rs36204709; rs10118903; rs36204707; rs36204706; rs36204712; rs34601856; rs10117208; rs10120784; rs10264; rs1054775; rs10760503; rs10819309; rs10987734; rs10987735; rs10987736; rs10987737; rs10987740; rs10987746; rs12001427; rs12379987; rs13300241; rs1330683; rs1330684; rs1544105; rs15630; rs34116890; rs34828244; rs4338213; rs5031024; rs5031025; rs5031026; rs5031027; rs6478796; rs7018778; rs7024560; rs7033913; rs7039798

# Macromolecular_Interacting_Partner_6_General_References:
1409616; 7721888; 8521387; 3828320

# Macromolecular_Interacting_Partner_6_References:
16122883; 16302815

# Macromolecular_Interacting_Partner_7_ID:
7811

# Macromolecular_Interacting_Partner_7_Name:
Folate receptor alpha precursor

# Macromolecular_Interacting_Partner_7_Synonyms:
FR-alpha; Folate receptor 1; Folate receptor, adult; Adult folate-binding protein; FBP; Ovarian tumor- associated antigen MOv18; KB cells FBP

# Macromolecular_Interacting_Partner_7_Gene_Name:
FOLR1

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Folate receptor alpha precursor
MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPW
RKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQV
DQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHF
YFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWA
AWPFLLSLALMLLWLLS

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
257

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
29819

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
8.02

# Macromolecular_Interacting_Partner_7_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF03024:Folate_rec

# Macromolecular_Interacting_Partner_7_Signals:
1-24

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
239-256

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
182416

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
FOLR1_HUMAN (P15328)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
FOLR1

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
FOLR1

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:3791

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor. Secreted protein (Probable)

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>774 bp
ATGGCTCAGCGGATGACAACACAGCTGCTGCTCCTTCTAGTGTGGGTGGCTGTAGTAGGG
GAGGCTCAGACAAGGATTGCATGGGCCAGGACTGAGCTTCTCAATGTCTGCATGAACGCC
AAGCACCACAAGGAAAAGCCAGGCCCCGAGGACAAGTTGCATGAGCAGTGTCGACCCTGG
AGGAAGAATGCCTGCTGTTCTACCAACACCAGCCAGGAAGCCCATAAGGATGTTTCCTAC
CTATATAGATTCAACTGGAACCACTGTGGAGAGATGGCACCTGCCTGCAAACGGCATTTC
ATCCAGGACACCTGCCTCTACGAGTGCTCCCCCAACTTGGGGCCCTGGATCCAGCAGGTG
GATCAGAGCTGGCGCAAAGAGCGGGTACTGAACGTGCCCCTGTGCAAAGAGGACTGTGAG
CAATGGTGGGAAGATTGTCGCACCTCCTACACCTGCAAGAGCAACTGGCACAAGGGCTGG
AACTGGACTTCAGGGTTTAACAAGTGCGCAGTGGGAGCTGCCTGCCAACCTTTCCATTTC
TACTTCCCCACACCCACTGTTCTGTGCAATGAAATCTGGACTCACTCCTACAAGGTCAGC
AACTACAGCCGAGGGAGTGGCCGCTGCATCCAGATGTGGTTCGACCCAGCCCAGGGCAAC
CCCAATGAGGAGGTGGCGAGGTTCTATGCTGCAGCCATGAGTGGGGCTGGGCCCTGGGCA
GCCTGGCCTTTCCTGCTTAGCCTGGCCCTAATGCTGCTGTGGCTGCTCAGCTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
M28099

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_7_Locus:
11q13.3-q14.1

# Macromolecular_Interacting_Partner_7_SNPs:
rs7928649; rs7125189; rs7109250; rs2071010; rs1540087; rs3833748; rs3763796; rs499087; rs7928531; rs7925351; rs9282688; rs7938303; rs17162056; rs7938669; rs630074; rs7939650; rs1801932; rs35179028; rs34465999; rs762621; rs5792581; rs35340702; rs1803570; rs7113391; rs5792580; rs762622; rs34217205; rs34345837; rs10628835; rs34116110; rs35968400; rs7479514; rs35805771; rs34989500; rs34400244; rs34219351; rs34030891; rs5792579; rs10501409; rs11235462; rs11235464; rs11235465; rs11235466; rs17162064; rs17162069; rs34468529; rs34575766

# Macromolecular_Interacting_Partner_7_General_References:
2527252; 2768245; 1717147; 1840502; 1581364; 2538429; 3476960; 7578066

# Macromolecular_Interacting_Partner_7_References:
16000291; 16089466; 16129577; 16142970

# Macromolecular_Interacting_Partner_8_ID:
7978

# Macromolecular_Interacting_Partner_8_Name:
Folate transporter 1

# Macromolecular_Interacting_Partner_8_Synonyms:
Solute carrier family 19 member 1; Placental folate transporter; FOLT; Reduced folate carrier protein; RFC; Intestinal folate carrier; IFC-1

# Macromolecular_Interacting_Partner_8_Gene_Name:
SLC19A1

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Folate transporter 1
MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFT
REQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQ
LMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRV
SFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGH
ALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTN
SARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPS
SIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSD
VRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKA
AQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPV
TTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
591

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
64869

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
9.10

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
Function:  electrochemical potential-driven transporter activity
Function:  porter activity
Function:  reduced folate carrier activity
Function:  binding
Function:  vitamin binding
Function:  folic acid binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF01770:Folate_carrier

# Macromolecular_Interacting_Partner_8_Signals:
None

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
24-44
71-89
96-116
124-144
160-177
187-203
260-287
310-327
334-354
361-378
395-419
434-454

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
1222523

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
S19A1_HUMAN (P41440)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
SLC19A1

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
SLC19A1

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:10937

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1776 bp
ATGGTGCCCTCCAGCCCAGCGGTGGAGAAGCAGGTGCCCGTGGAACCTGGGCCTGACCCC
GAGCTCCGGTCCTGGCGGCGCCTCGTGTGCTACCTTTGCTTCTACGGCTTCATGGCGCAG
ATACGGCCAGGGGAGAGCTTCATCACCCCCTACCTCCTGGGGCCCGACAAGAACTTCACG
CGGGACGAGGTCACGAACGAGATCACGCCGGTGCTGTCGTACTCCTACCTGGCCGTGCTG
GTGCCCGTGTTCCTGCTCACCGACTACCTGCGCTACACGCCGGTGCTGCTGCTGCAGGGG
CTCAGCTTCGTGTCGGTGTGGCTGCTGCTGCTGCTGGGCCACTCGGTGGCGCACATGCAG
CTCATGGAGCTCTTCTACAGCGTCACCATGGCCGCGCGCATCGCCTATTCCTCCTACATC
TTCTCTCTCGTGCGGCCCGCGCGCTACCAGCGTGTGGCCGGCTACTCGCGCGCTGCGGTG
CTGCTGGGCGTGTTCACCAGCTCCGTGCTGGGCCAGCTGCTGGTCACTGTGGGCCGAGTC
TCCTTCTCCACGCTCAACTACATCTCGCTGGCCTTCCTCACCTTCAGCGTGGTCCTCGCC
CTCTTCCTGAAGCGCCCCAAGCGCAGCCTCTTCTTCAACCGCGACGACCGGGGGCGGTGC
GAAACCTCGGCTTCGGAGCTGGAGCGCATGAATCCCGGCCCAGGCGGGAAGCTGGGACAC
GCCCTGCGGGTGGCCTGTGGGGACTCAGTGCTGGCGCGGATGCTGCGGGAGCTGGGGGAC
AGCCTGCGGCGGCCGCAGCTGCCCCTGTGGTCCCTCTGGTGGGTCTTCAACTCGGCCGGC
TACTACCTGGTGGTCTACTACGTGCACATCCTGTGGAACGAGGTGGACCCCACCACCAAC
AGTGCGCGGGTCTACAACGGCGCGGCAGATGCTGCCTCCACGCTGCTGGGCGCCATCACG
TCCTTCGCCGCGGGCTTCGTGAAGATCCGCTGGGCGCGCTGGTCCAAGCTGCTCATCGCG
GGCGTCACGGCCACGCAGGCGGGGCTGGTCTTCCTTCTGGCGCACACGCGCCACCCGAGC
AGCATCTGGCTGTGCTATGCGGCCTTCGTGCTGTTCCGCGGCTCCTACCAGTTCCTCGTG
CCCATCGCCACCTTTCAGATTGCATCTTCTCTGTCTAAAGAGCTCTGTGCCCTGGTCTTC
GGGGTCAACACGTTCTTTGCCACCATCGTCAAGACCATCATCACTTTCATTGTCTCGGAC
GTGCGGGGCCTGGGCCTCCCGGTCCGCAAGCAGTTCCAGTTATACTCCGTGTACTTCCTG
ATCCTGTCCATCATCTACTTCTTGGGGGCCATGCTGGATGGCCTGCGGCACTGCCAGCGG
GGCCACCACCCGCGGCAGCCCCCGGCCCAGGGCCTGAGGAGTGCCGCGGAGGAGAAGGCA
GCACAGGCACTGAGCGTGCAGGACAAGGGCCTCGGAGGCCTGCAGCCAGCCCAGAGCCCG
CCGCTTTCCCCAGAAGACAGCCTGGGGGCTGTGGGGCCAGCCTCCCTGGAGCAGAGACAG
AGCGACCCATACCTGGCCCAGGCCCCGGCCCCGCAGGCAGCTGAATTCCTGAGCCCAGTG
ACAACCCCTTCCCCCTGCACTCTGTCGTCCGCCCAAGCCTCAGGCCCTGAGGCTGCAGAT
GAGACTTGTCCCCAGCTGGCTGTCCATCCTCCTGGTGTCAGCAAGCTGGGTTTGCAGTGT
CTTCCAAGCGACGGTGTTCAGAATGTGAACCAGTGA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
U15939

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_8_Locus:
Not Available

# Macromolecular_Interacting_Partner_8_SNPs:
rs1051266; rs35786590; rs12659; rs9282853; rs1051296; rs2010540; rs3788203; rs2330183; rs1051298; rs3788202; rs914232; rs4819130; rs3788200; rs13050920; rs3788199; rs9976727; rs2330182; rs4818790; rs9977610; rs914231; rs1888531; rs3827265; rs35764705; rs12329692; rs3788201; rs4987217; rs7509663; rs4311136; rs13052294; rs11702537; rs2330184; rs1888532; rs3177999; rs12106284; rs2838956; rs1888530; rs2838957; rs2838958; rs3788189; rs4819128; rs4818786; rs7278332; rs1888529; rs3788191; rs9306134; rs12482346; rs4818789; rs2297291; rs11089011; rs9306132; rs11701985; rs9975958; rs4818788; rs2039277; rs9978293; rs9982301; rs9979694; rs11089010; rs4819129; rs11702591; rs4819127; rs965933; rs11089012; rs9306133; rs11089013; rs3746985; rs2039278; rs3788190; rs9306135; rs9976313; rs4818787; rs9980386; rs2838955; rs9978677; rs3838134; rs16979529; rs9917539; rs9978673; rs7278825; rs1051269; rs9282854; rs35421985; rs9977985; rs35978794; rs9974325; rs9680103; rs7510226; rs28737388; rs35387515; rs11284347; rs5844241; rs34196997; rs2297292; rs3831211; rs11329241; rs9976224; rs9974515; rs13048427; rs11426397; rs35123999; rs3028044; rs34593445; rs34393613; rs9984436; rs35718273; rs3788197; rs12106470; rs9982270; rs35100713; rs762782; rs13052709; rs3028039; rs9984419; rs28627372; rs11701436; rs35727413; rs28722137; rs13050001; rs13052677; rs11702003; rs28448590; rs3833366; rs28568291; rs28756113; rs9979328; rs9647238; rs2330181; rs7278430; rs28417948; rs7509787; rs10460742; rs33981341; rs10644910; rs34845874; rs13046287; rs13046919; rs35809128; rs11434243; rs9984404; rs11702487; rs28665979; rs10545855; rs2039276; rs9798633; rs28413786; rs7280587; rs13051456; rs11281978; rs36230821; rs3788204; rs36230819; rs35797010; rs36230817; rs36230815; rs35132960; rs9978086; rs36230818; rs36230816; rs13051342; rs36230820; rs3746987; rs36230814; rs1023159; rs10483080; rs1050351; rs1063505; rs11701905; rs11908961; rs12483377; rs12483553; rs12483761; rs17004784; rs17004785; rs2236483; rs2236484; rs2838950; rs2838951; rs2838952; rs2838954; rs3753019; rs3788205; rs3939250; rs4818791; rs7278425; rs7499; rs7867; rs8199; rs9653779; rs9975694; rs9983050; rs9983151

# Macromolecular_Interacting_Partner_8_General_References:
7826387; 7615551; 7641195; 7852378; 9041240; 10830953; 10347183

# Macromolecular_Interacting_Partner_8_References:
15952116; 15958060; 15964598; 16019224

# Macromolecular_Interacting_Partner_9_ID:
8231

# Macromolecular_Interacting_Partner_9_Name:
Low-density lipoprotein receptor-related protein 2 precursor

# Macromolecular_Interacting_Partner_9_Synonyms:
Megalin; Glycoprotein 330; gp330

# Macromolecular_Interacting_Partner_9_Gene_Name:
LRP2

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Lowdensity lipoprotein receptorrelated protein 2 precursor
MDRGPAAVACTLLLALVACLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEI
GCAVVTCQQGYFKCQSEGQCIPSSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQC
IPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCT
EICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWV
CDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENN
TSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQ
KCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVES
QNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNK
IYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLER
AFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSL
IPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYAT
NPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIR
GIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAA
NRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLNNPRSVVVHPFAGYL
FFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFD
GLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHL
KSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNE
PPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECI
PAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDE
KNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKC
IGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGS
DEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCL
GHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFL
LANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLV
ASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDR
RVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALD
PRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLD
YMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVM
YNIQWPLGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNC
LRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGE
IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTL
IANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEH
LECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQY
EVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGL
FSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHV
DVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLY
FTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFL
DCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTP
YGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAE
VNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNCAISTENFLIFALSNSLRS
LHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTV
IASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGY
LYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTL
TGVDREVIVNAAVHAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGI
NTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERC
GASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRC
DYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDR
TCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQH
WYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKR
HQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTC
GYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDG
SDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSIS
GCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAP
GYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKR
LYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLN
GGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVII
STKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTI
YWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLC
LIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSD
GSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQ
CANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDC
GDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCH
PVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDH
YNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGA
YCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSH
EVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDEL
GCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQH
CRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQD
EEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKY
VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF
WTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYD
GTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRI
FHQLRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPP
CRCMHGGNCYFDETDLPKCKCPSGYTGKYCEMAFSKGISPGTTAVAVLLTILLIVVIGAL
AIAGFFHYRRTGSLLPALPKLPSLSSLVKPSENGNGVTFRSGADLNMDIGVSGFGPETAI
DRSMAMSEDFVMEMGKQPIIFENPMYSARDSAVKVVQPIQVTVSENVDNKNYGSPINPSE
IVPETNPTSPAADGTQVTKWNLFKRKSKQTTNFENPIYAQMENEQKESVAATPPPSPSLP
AKPKPPSRRDPTPTYSATEDTFKDTANLVKEDSEV

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
4655

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
521933

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
4.68

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
May participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00008:EGF;
PF07974:EGF_2;
PF07645:EGF_CA;
PF00057:Ldl_recept_a;
PF00058:Ldl_recept_b

# Macromolecular_Interacting_Partner_9_Signals:
1-25

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
4424-4446

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
1809240

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
LRP2_HUMAN (P98164)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
LRP2

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
LRP2

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:6694

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>13968 bp
ATGGATCGCGGGCCGGCAGCAGTGGCGTGCACGCTGCTCCTGGCTCTCGTCGCCTGCCTA
GCGCCGGCCAGTGGCCAAGAATGTGACAGTGCGCATTTTCGCTGTGGAAGTGGGCATTGC
ATCCCTGCAGACTGGAGGTGTGATGGGACCAAAGACTGTTCAGATGACGCGGATGAAATT
GGCTGCGCTGTTGTGACCTGCCAGCAGGGCTATTTCAAGTGCCAGAGTGAGGGACAATGC
ATCCCCAGCTCCTGGGTGTGTGACCAAGATCAAGACTGTGATGATGGCTCAGATGAACGT
CAAGATTGCTCACAAAGTACATGCTCAAGTCATCAGATAACATGCTCCAATGGTCAGTGT
ATCCCAAGTGAATACAGGTGCGACCACGTCAGAGACTGCCCCGATGGAGCTGATGAGAAT
GACTGCCAGTACCCAACATGTGAGCAGCTTACTTGTGACAATGGGGCCTGCTATAACACC
AGTCAGAAGTGTGATTGGAAAGTTGATTGCAGGGACTCCTCAGATGAAATCAACTGCACT
GAGATATGCTTGCACAATGAGTTTTCATGTGGCAATGGAGAGTGTATCCCTCGTGCTTAT
GTCTGTGACCATGACAATGATTGCCAAGACGGCAGTGATGAACATGCTTGCAACTATCCG
ACCTGCGGTGGTTACCAGTTCACTTGCCCCAGTGGCCGATGCATTTATCAAAACTGGGTT
TGTGATGGAGAAGATGACTGTAAAGATAATGGAGATGAAGATGGATGTGAAAGCGGTCCT
CATGATGTTCATAAATGTTCCCCAAGAGAATGGTCTTGCCCAGAGTCGGGACGATGCATC
TCCATTTATAAAGTTTGTGATGGGATTTTAGATTGCCCAGGAAGAGAAGATGAAAACAAC
ACTAGTACCGGAAAATACTGTAGTATGACTCTGTGCTCTGCCTTGAACTGCCAGTACCAG
TGCCATGAGACGCCGTATGGAGGAGCGTGTTTTTGTCCCCCAGGTTATATCATCAACCAC
AATGACAGCCGTACCTGTGTTGAGTTTGATGATTGCCAGATATGGGGAATTTGTGACCAG
AAGTGTGAAAGCCGACCTGGCCGTCACCTGTGCCACTGTGAAGAAGGGTATATCTTGGAG
CGTGGACAGTATTGCAAAGCTAATGATTCCTTTGGCGAGGCCTCCATTATCTTCTCCAAT
GGTCGGGATTTGTTAATTGGTGATATTCATGGAAGGAGCTTCCGGATCCTAGTGGAGTCT
CAGAATCGTGGAGTGGCCGTGGGTGTGGCTTTCCACTATCACCTGCAAAGAGTTTTTTGG
ACAGACACCGTGCAAAATAAGGTTTTTTCAGTTGACATTAATGGTTTAAATATCCAAGAG
GTTCTCAATGTTTCTGTTGAAACCCCAGAGAACCTGGCTGTGGACTGGGTTAATAATAAA
ATCTATCTAGTGGAAACCAAGGTCAACCGCATAGATATGGTAAATTTGGATGGAAGCTAT
CGGGTTACCCTTATAACTGAAAACTTGGGGCATCCTAGAGGAATTGCCGTGGACCCAACT
GTTGGTTATTTATTTTTCTCAGATTGGGAGAGCCTTTCTGGGGAACCTAAGCTGGAAAGG
GCATTCATGGATGGCAGCAACCGTAAAGACTTGGTGAAAACAAAGCTGGGATGGCCTGCT
GGGGTAACTCTGGATATGATATCGAAGCGTGTTTACTGGGTTGACTCTCGGTTTGATTAC
ATTGAAACTGTAACTTATGATGGAATTCAAAGGAAGACTGTAGTTCATGGAGGCTCCCTC
ATTCCTCATCCCTTTGGAGTAAGCTTATTTGAAGGTCAGGTGTTCTTTACAGATTGGACA
AAGATGGCCGTGCTGAAGGCAAACAAGTTCACAGAGACCAACCCACAAGTGTACTACCAG
GCTTCCCTGAGGCCCTATGGAGTGACTGTTTACCATTCCCTCAGACAGCCCTATGCTACC
AATCCGTGTAAAGATAACAATGGGGGCTGTGAGCAGGTCTGTGTTCTCAGCCACAGAACA
GATAATGATGGTTTGGGTTTCCGTTGCAAGTGCACATTCGGCTTCCAACTGGATACAGAT
GAGCGCCACTGCATTGCTGTTCAGAATTTCCTCATTTTTTCATCCCAAGTTGCTATTCGT
GGGATCCCGTTCACCTTGTCTACCCAGGAAGATGTCATGGTTCCAGTTTCGGGGAATCCT
TCTTTCTTTGTCGGGATTGATTTTGACGCCCAGGACAGCACTATCTTTTTTTCAGATATG
TCAAAACACATGATTTTTAAGCAAAAGATTGATGGCACAGGAAGAGAAATTCTCGCAGCT
AACAGGGTGGAAAATGTTGAAAGTTTGGCTTTTGATTGGATTTCAAAGAATCTCTATTGG
ACAGACTCTCATTACAAGAGTATCAGTGTCATGAGGCTAGCTGATAAAACGAGACGCACA
GTAGTTCAGTATTTAAATAACCCACGGTCGGTGGTAGTTCATCCTTTTGCCGGGTATCTA
TTCTTCACTGATTGGTTCCGTCCTGCTAAAATTATGAGAGCATGGAGTGACGGATCTCAC
CTCTTGCCTGTAATAAACACTACTCTTGGATGGCCCAATGGCTTGGCCATCGATTGGGCT
GCTTCACGATTGTACTGGGTAGATGCCTATTTTGATAAAATTGAGCACAGCACCTTTGAT
GGTTTAGACAGAAGAAGACTGGGCCATATAGAGCAGATGACACATCCGTTTGGACTTGCC
ATCTTTGGAGAGCATTTATTTTTTACTGACTGGAGACTGGGTGCCATTATTCGAGTCAGG
AAAGCAGATGGTGGAGAAATGACAGTTATCCGAAGTGGCATTGCTTACATACTGCATTTG
AAATCGTATGATGTCAACATCCAGACTGGTTCTAACGCCTGTAATCAACCCACGCATCCT
AACGGTGACTGCAGCCACTTCTGCTTCCCGGTGCCAAATTTCCAGCGAGTGTGTGGGTGC
CCTTATGGAATGAGGCTGGCTTCCAATCACTTGACATGCGAGGGGGACCCAACCAATGAA
CCACCCACGGAGCAGTGTGGCTTATTTTCCTTCCCCTGTAAAAATGGCAGATGTGTGCCC
AATTACTATCTCTGTGATGGAGTCGATGATTGTCATGATAACAGTGATGAGCAACTATGT
GGCACACTTAATAATACCTGTTCATCTTCGGCGTTCACCTGTGGCCATGGGGAGTGCATT
CCTGCACACTGGCGCTGTGACAAACGCAACGACTGTGTGGATGGCAGTGATGAGCACAAC
TGCCCCACCCACGCACCTGCTTCCTGCCTTGACACCCAATACACCTGTGATAATCACCAG
TGTATCTCAAAGAACTGGGTCTGTGACACAGACAATGATTGTGGGGATGGATCTGATGAA
AAGAACTGCAATTCGACAGAGACATGCCAACCTAGTCAGTTTAATTGCCCCAATCATCGA
TGTATTGACCTATCGTTTGTCTGTGATGGTGACAAGGATTGTGTTGATGGATCTGATGAG
GTTGGTTGTGTATTAAACTGTACTGCTTCTCAATTCAAGTGTGCCAGTGGGGATAAATGT
ATTGGCGTCACAAATCGTTGTGATGGTGTTTTTGATTGCAGTGACAACTCGGATGAAGCG
GGCTGTCCAACCAGGCCTCCTGGTATGTGCCACTCAGATGAATTTCAGTGCCAAGAAGAT
GGTATCTGCATCCCGAACTTCTGGGAATGTGATGGGCATCCAGACTGCCTCTATGGATCT
GATGAGCACAATGCCTGTGTCCCCAAGACTTGCCCTTCATCATATTTCCACTGTGACAAC
GGAAACTGCATCCACAGGGCATGGCTCTGTGATCGGGACAATGACTGCGGGGATATGAGT
GATGAGAAGGACTGCCCTACTCAGCCCTTTCGCTGTCCTAGTTGGCAATGGCAGTGTCTT
GGCCATAACATCTGTGTGAATCTGAGTGTAGTGTGTGATGGCATCTTTGACTGCCCCAAT
GGGACAGATGAGTCCCCACTTTGCAATGGGAACAGCTGCTCAGATTTCAATGGTGGTTGT
ACTCACGAGTGTGTTCAAGAGCCCTTTGGGGCTAAATGCCTATGTCCATTGGGATTCTTA
CTTGCCAATGATTCTAAGACCTGTGAAGACATAGATGAATGTGATATTCTAGGCTCTTGT
AGCCAGCACTGTTACAATATGAGAGGTTCTTTCCGGTGCTCGTGTGATACAGGCTACATG
TTAGAAAGTGATGGGAGGACTTGCAAAGTTACAGCATCTGAGAGTCTGCTGTTACTTGTG
GCAAGTCAGAACAAAATTATTGCCGACAGTGTCACCTCCCAGGTCCACAATATCTATTCA
TTGGTCGAGAATGGTTCTTACATTGTAGCTGTTGATTTTGATTCAATTAGTGGTCGTATC
TTTTGGTCTGATGCAACTCAGGGTAAAACCTGGAGTGCGTTTCAAAATGGAACGGACAGA
AGAGTGGTATTTGACAGTAGCATCATCTTGACTGAAACTATTGCAATAGATTGGGTAGGT
CGTAATCTTTACTGGACAGACTATGCTCTGGAAACAATTGAAGTCTCCAAAATTGATGGG
AGCCACAGGACTGTGCTGATTAGTAAAAACCTAACAAATCCAAGAGGACTAGCATTAGAT
CCCAGAATGAATGAGCATCTACTGTTCTGGTCTGACTGGGGCCACCACCCTCGCATCGAG
CGAGCCAGCATGGACGGCAGCATGCGCACTGTCATTGTCCAGGACAAGATCTTCTGGCCC
TGCGGCTTAACTATTGACTACCCCAACAGACTGCTCTACTTCATGGACTCCTATCTTGAT
TACATGGACTTTTGCGATTATAATGGACACCATCGGAGACAGGTGATAGCCAGTGATTTG
ATTATACGGCACCCCTATGCCCTAACTCTCTTTGAAGACTCTGTGTACTGGACTGACCGT
GCTACTCGTCGGGTTATGCGAGCCAACAAGTGGCATGGAGGGAACCAGTCAGTTGTAATG
TATAATATTCAATGGCCCCTTGGGATTGTTGCGGTTCATCCTTCGAAACAACCAAATTCC
GTGAATCCATGTGCCTTTTCCCGCTGCAGCCATCTCTGCCTGCTTTCCTCACAGGGGCCT
CATTTTTACTCCTGTGTTTGTCCTTCAGGATGGAGTCTGTCTCCTGATCTCCTGAATTGC
TTGAGAGATGATCAACCTTTCTTAATAACTGTAAGGCAACATATAATTTTTGGAATCTCC
CTTAATCCTGAGGTGAAGAGCAATGATGCTATGGTCCCCATAGCAGGGATACAGAATGGT
TTAGATGTTGAATTTGATGATGCTGAGCAATACATCTATTGGGTTGAAAATCCAGGTGAA
ATTCACAGAGTGAAGACAGATGGCACCAACAGGACAGTATTTGCTTCTATATCTATGGTG
GGGCCTTCTATGAACCTGGCCTTAGATTGGATTTCAAGAAACCTTTATTCTACCAATCCT
AGAACTCAGTCAATCGAGGTTTTGACACTCCACGGAGATATCAGATACAGAAAAACATTG
ATTGCCAATGATGGGACAGCTCTTGGAGTTGGCTTTCCAATTGGCATAACTGTTGATCCT
GCTCGTGGGAAGCTGTACTGGTCAGACCAAGGAACTGACAGTGGGGTTCCTGCCAAGATC
GCCAGTGCTAACATGGATGGCACATCTGTGAAAACTCTCTTTACTGGGAACCTCGAACAC
CTGGAGTGTGTCACTCTTGACATCGAAGAGCAGAAACTCTACTGGGCAGTCACTGGAAGA
GGAGTGATTGAAAGAGGAAACGTGGATGGAACAGATCGGATGATCCTGGTACACCAGCTT
TCCCACCCCTGGGGAATTGCAGTCCATGATTCTTTCCTTTATTATACTGATGAACAGTAT
GAGGTCATTGAAAGAGTTGATAAGGCCACTGGGGCCAACAAAATAGTCTTGAGAGATAAT
GTTCCAAATCTGAGGGGTCTTCAAGTTTATCACAGACGCAATGCCGCCGAATCCTCAAAT
GGCTGTAGCAACAACATGAATGCCTGTCAGCAGATTTGCCTGCCTGTACCAGGAGGATTG
TTTTCCTGCGCCTGTGCCACTGGATTTAAACTCAATCCTGATAATCGGTCCTGCTCTCCA
TATAACTCTTTCATTGTTGTTTCAATGCTGTCTGCAATCAGAGGCTTTAGCTTGGAATTG
TCAGATCATTCAGAAACCATGGTGCCGGTGGCAGGCCAAGGACGAAACGCACTGCATGTG
GATGTGGATGTGTCCTCTGGCTTTATTTATTGGTGTGATTTTAGCAGCTCAGTGGCATCT
GATAATGCGATCCGTAGAATTAAACCAGATGGATCTTCTCTGATGAACATTGTGACACAT
GGAATAGGAGAAAATGGAGTCCGGGGTATTGCAGTGGATTGGGTAGCAGGAAATCTTTAT
TTCACCAATGCCTTTGTTTCTGAAACACTGATAGAAGTTCTGCGGATCAATACTACTTAC
CGCCGTGTTCTTCTTAAAGTCACAGTGGACATGCCTAGGCATATTGTTGTAGATCCCAAG
AACAGATACCTCTTCTGGGCTGACTATGGGCAGAGACCAAAGATTGAGCGTTCTTTCCTT
GACTGTACCAATCGAACAGTGCTTGTGTCAGAGGGCATTGTCACACCACGGGGCTTGGCA
GTGGACCGAAGTGATGGCTACGTTTATTGGGTTGATGATTCTTTAGATATAATTGCAAGG
ATTCGTATCAATGGAGAGAACTCTGAAGTGATTCGTTATGGCAGTCGTTACCCAACTCCT
TATGGCATCACTGTTTTTGAAAATTCTATCATATGGGTAGATAGGAATTTGAAAAAGATC
TTCCAAGCCAGCAAGGAACCAGAGAACACAGAGCCACCCACAGTGATAAGAGACAATATC
AACTGGCTAAGAGATGTGACCATCTTTGACAAGCAAGTCCAGCCCCGGTCACCAGCAGAG
GTCAACAACAACCCTTGCTTGGAAAACAATGGTGGGTGCTCTCATCTCTGCTTTGCTCTG
CCTGGATTGCACACCCCAAAATGTGACTGTGCCTTTGGGACCCTGCAAAGTGATGGCAAG
AATTGTGCCATTTCAACAGAAAATTTCCTCATCTTTGCCTTGTCTAATTCCTTGAGAAGC
TTACACTTGGACCCTGAAAACCATAGCCCACCTTTCCAAACAATAAATGTGGAAAGAACT
GTCATGTCTCTAGACTATGACAGTGTAAGTGATAGAATCTACTTCACACAAAATTTAGCC
TCTGGAGTTGGACAGATTTCCTATGCCACCCTGTCTTCAGGGATCCATACTCCAACTGTC
ATTGCTTCAGGTATAGGGACTGCTGATGGCATTGCCTTTGACTGGATTACTAGAAGAATT
TATTACAGTGACTACCTCAACCAGATGATTAATTCCATGGCTGAAGATGGGTCTAACCGC
ACTGTGATAGCCCGCGTTCCAAAACCAAGAGCAATTGTGTTAGATCCCTGCCAAGGGTAC
CTGTACTGGGCTGACTGGGATACACATGCCAAAATCGAGAGAGCCACATTGGGAGGAAAC
TTCCGGGTACCCATTGTGAACAGCAGTCTGGTCATGCCCAGTGGGCTGACTCTGGACTAT
GAAGAGGACCTTCTCTACTGGGTGGATGCTAGTCTGCAGAGGATTGAACGCAGCACTCTG
ACGGGCGTGGATCGTGAAGTCATTGTCAATGCAGCCGTTCATGCTTTTGGCTTGACTCTC
TATGGCCAGTATATTTACTGGACTGACTTGTACACACAAAGAATTTACCGAGCTAACAAA
TATGACGGGTCAGGTCAGATTGCAATGACCACAAATTTGCTCTCCCAGCCCAGGGGAATC
AACACTGTTGTGAAGAACCAGAAACAACAGTGTAACAATCCTTGTGAACAGTTTAATGGG
GGCTGCAGCCATATCTGTGCACCAGGTCCAAATGGTGCCGAGTGCCAGTGTCCACATGAG
GGCAACTGGTATTTGGCCAACAACAGGAAGCACTGCATTGTGGACAATGGTGAACGATGT
GGTGCATCTTCCTTCACCTGCTCCAATGGGCGCTGCATCTCGGAAGAGTGGAAGTGTGAT
AATGACAACGACTGTGGGGATGGCAGTGATGAGATGGAAAGTGTCTGTGCACTTCACACC
TGCTCACCGACAGCCTTCACCTGTGCCAATGGGCGATGTGTCCAATACTCTTACCGCTGT
GATTACTACAATGACTGTGGTGATGGCAGTGATGAGGCAGGGTGCCTGTTCAGGGACTGC
AATGCCACCACGGAGTTTATGTGCAATAACAGAAGGTGCATACCTCGTGAGTTTATCTGC
AATGGTGTAGACAACTGCCATGATAATAACACTTCAGATGAGAAAAATTGCCCTGATCGC
ACTTGCCAGTCTGGATACACAAAATGTCATAATTCAAATATTTGTATTCCTCGCGTTTAT
TTGTGTGACGGAGACAATGACTGTGGAGATAACAGTGATGAAAACCCTACTTATTGCACC
ACTCACACATGCAGCAGCAGTGAGTTCCAATGCGCATCTGGGCGCTGTATTCCTCAACAT
TGGTATTGTGATCAAGAAACAGATTGTTTTGATGCCTCTGATGAACCTGCCTCTTGTGGT
CACTCTGAGCGAACATGCCTAGCTGATGAGTTCAAGTGTGATGGTGGGAGGTGCATCCCA
AGCGAATGGATCTGTGACGGTGATAATGACTGTGGGGATATGAGTGACGAGGATAAAAGG
CACCAGTGTCAGAATCAAAACTGCTCGGATTCCGAGTTTCTCTGTGTAAATGACAGACCT
CCGGACAGGAGGTGCATTCCCCAGTCTTGGGTCTGTGATGGCGATGTGGATTGTACTGAC
GGCTACGATGAGAATCAGAATTGCACCAGGAGAACTTGCTCTGAAAATGAATTCACCTGT
GGTTACGGACTGTGTATCCCAAAGATATTCAGGTGTGACCGGCACAATGACTGTGGTGAC
TATAGCGACGAGAGGGGCTGCTTATACCAGACTTGCCAACAGAATCAGTTTACCTGTCAG
AACGGGCGCTGCATTAGTAAAACCTTCGTCTGTGATGAGGATAATGACTGTGGAGACGGA
TCTGATGAGCTGATGCACCTGTGCCACACCCCAGAACCCACGTGTCCACCTCACGAGTTC
AAGTGTGACAATGGGCGCTGCATCGAGATGATGAAACTCTGCAACCACCTAGATGACTGT
TTGGACAACAGCGATGAGAAAGGCTGTGGCATTAATGAATGCCATGACCCTTCAATCAGT
GGCTGCGATCACAACTGCACAGACACCTTAACCAGTTTCTATTGTTCCTGTCGTCCTGGT
TACAAGCTCATGTCTGACAAGCGGACTTGTGTTGATATTGATGAATGCACAGAGATGCCT
TTTGTCTGTAGCCAGAAGTGTGAGAATGTAATAGGCTCCTACATCTGTAAGTGTGCCCCA
GGCTACCTCCGAGAACCAGATGGAAAGACCTGCCGGCAAAACAGTAACATCGAACCCTAT
CTCATTTTTAGCAACCGTTACTATTTGAGAAATTTAACTATAGATGGCTATTTTTACTCC
CTCATCTTGGAAGGACTGGACAATGTTGTGGCATTAGATTTTGACCGAGTAGAGAAGAGA
TTGTATTGGATTGATACACAGAGGCAAGTCATTGAGAGAATGTTTCTGAATAAGACAAAC
AAGGAGACAATCATAAACCACAGACTACCAGCTGCAGAAAGTCTGGCTGTAGACTGGGTT
TCCAGAAAGCTCTACTGGTTGGATGCCCGCCTGGATGGCCTCTTTGTCTCTGACCTCAAT
GGTGGACACCGCCGCATGCTGGCCCAGCACTGTGTGGATGCCAACAACACCTTCTGCTTT
GATAATCCCAGAGGACTTGCCCTTCACCCTCAATATGGGTACCTCTACTGGGCAGACTGG
GGTCACCGCGCATACATTGGGAGAGTAGGCATGGATGGAACCAACAAGTCTGTGATAATC
TCCACCAAGTTAGAGTGGCCTAATGGCATCACCATTGATTACACCAATGATCTACTCTAC
TGGGCAGATGCCCACCTGGGTTACATAGAGTACTCTGATTTGGAGGGCCACCATCGACAC
ACGGTGTATGATGGGGCACTGCCTCACCCTTTCGCTATTACCATTTTTGAAGACACTATT
TATTGGACAGATTGGAATACAAGGACAGTGGAAAAGGGAAACAAATATGATGGATCAAAT
AGACAGACACTGGTGAACACAACACACAGACCATTTGACATCCATGTGTACCATCCATAT
AGGCAGCCCATTGTGAGCAATCCCTGTGGTACCAACAATGGTGGCTGTTCTCATCTCTGC
CTCATCAAGCCAGGAGGAAAAGGGTTCACTTGCGAGTGTCCAGATGACTTCCGCACCCTT
CAACTGAGTGGCAGCACCTACTGCATGCCCATGTGCTCCAGCACCCAGTTCCTGTGCGCT
AACAATGAAAAGTGCATTCCTATCTGGTGGAAATGTGATGGACAGAAAGACTGCTCAGAT
GGCTCTGATGAACTGGCCCTTTGCCCGCAGCGCTTCTGCCGACTGGGACAGTTCCAGTGC
AGTGACGGCAACTGCACCAGCCCGCAGACTTTATGCAATGCTCACCAAAATTGCCCTGAT
GGGTCTGATGAAGACCGTCTTCTTTGTGAGAATCACCACTGTGACTCCAATGAATGGCAG
TGCGCCAACAAACGTTGCATCCCAGAATCCTGGCAGTGTGACACATTTAACGACTGTGAG
GATAACTCAGATGAAGACAGTTCCCACTGTGCCAGCAGGACCTGCCGGCCGGGCCAGTTT
CGGTGTGCTAATGGCCGCTGCATCCCGCAGGCCTGGAAGTGTGATGTGGATAATGATTGT
GGAGACCACTCGGATGAGCCCATTGAAGAATGCATGAGCTCTGCCCATCTCTGTGACAAC
TTCACAGAATTCAGCTGCAAAACAAATTACCGCTGCATCCCAAAGTGGGCCGTGTGCAAT
GGTGTAGATGACTGCAGGGACAACAGTGATGAGCAAGGCTGTGAGGAGAGGACATGCCAT
CCTGTGGGGGATTTCCGCTGTAAAAATCACCACTGCATCCCTCTTCGTTGGCAGTGTGAT
GGGCAAAATGACTGTGGAGATAACTCAGATGAGGAAAACTGTGCTCCCCGGGAGTGCACA
GAGAGCGAGTTTCGATGTGTCAATCAGCAGTGCATTCCCTCGCGATGGATCTGTGACCAT
TACAACGACTGTGGGGACAACTCAGATGAACGGGACTGTGAGATGAGGACCTGCCATCCT
GAATATTTTCAGTGTACAAGTGGACATTGTGTACACAGTGAACTGAAATGCGATGGATCC
GCTGACTGTTTGGATGCGTCTGATGAAGCTGATTGTCCCACACGCTTTCCTGATGGTGCA
TACTGCCAGGCTACTATGTTCGAATGCAAAAACCATGTTTGTATCCCGCCATATTGGAAA
TGTGATGGCGATGATGACTGTGGCGATGGTTCAGATGAAGAACTTCACCTGTGCTTGGAT
GTTCCCTGTAATTCACCAAACCGTTTCCGGTGTGACAACAATCGCTGCATTTATAGTCAT
GAGGTGTGCAATGGTGTGGATGACTGTGGAGATGGAACTGATGAGACAGAGGAGCACTGT
AGAAAACCGACCCCTAAACCTTGTACAGAATATGAATATAAGTGTGGCAATGGGCATTGC
ATTCCACATGACAATGTGTGTGATGATGCCGATGACTGTGGTGACTGGTCCGATGAACTG
GGTTGCAATAAAGGAAAAGAAAGAACATGTGCTGAAAATATATGCGAGCAAAATTGTACC
CAATTAAATGAAGGAGGATTTATCTGCTCCTGTACAGCTGGGTTCGAAACCAATGTTTTT
GACAGAACCTCCTGTCTAGATATCAATGAATGTGAACAATTTGGGACTTGTCCCCAGCAC
TGCAGAAATACCAAAGGAAGTTATGAGTGTGTCTGTGCTGATGGCTTCACGTCTATGAGT
GACCGCCCTGGAAAACGATGTGCAGCTGAGGGTAGCTCTCCTTTGTTGCTACTGCCTGAC
AATGTCCGAATTCGAAAATATAATCTCTCATCTGAGAGGTTCTCAGAGTATCTTCAAGAT
GAGGAATATATCCAAGCTGTTGATTATGATTGGGATCCCAAGGACATAGGCCTCAGTGTT
GTGTATTACACTGTGCGAGGGGAGGGCTCTAGGTTTGGTGCTATCAAACGTGCCTACATC
CCCAACTTTGAATCCGGCCGCAATAATCTTGTGCAGGAAGTTGACCTGAAACTGAAATAC
GTAATGCAGCCAGATGGAATAGCAGTGGACTGGGTTGGAAGGCATATTTACTGGTCAGAT
GTCAAGAATAAACGCATTGAGGTGGCTAAACTTGATGGAAGGTACAGAAAGTGGCTGATT
TCCACTGACCTGGACCAACCAGCTGCTATTGCTGTGAATCCCAAACTAGGGCTTATGTTC
TGGACTGACTGGGGAAAGGAACCTAAAATCGAGTCTGCCTGGATGAATGGAGAGGACCGC
AACATCCTGGTTTTCGAGGACCTTGGTTGGCCAACTGGCCTTTCTATCGATTATTTGAAC
AATGACCGAATCTACTGGAGTGACTTCAAGGAGGACGTTATTGAAACCATAAAATATGAT
GGGACTGATAGGAGAGTCATTGCAAAGGAAGCAATGAACCCTTACAGCCTGGACATCTTT
GAAGACCAGTTATACTGGATATCTAAGGAAAAGGGAGAAGTATGGAAACAAAATAAATTT
GGGCAAGGAAAGAAAGAGAAAACGCTGGTAGTGAACCCTTGGCTCACTCAAGTTCGAATC
TTTCATCAACTCAGATACAATAAGTCAGTGCCCAACCTTTGCAAACAGATCTGCAGCCAC
CTCTGCCTTCTGAGACCTGGAGGATACAGCTGTGCCTGTCCCCAAGGCTCCAGCTTTATA
GAGGGGAGCACCACTGAGTGTGATGCAGCCATCGAACTGCCTATCAACCTGCCCCCCCCA
TGCAGGTGCATGCACGGAGGAAATTGCTATTTTGATGAGACTGACCTCCCCAAATGCAAG
TGTCCTAGCGGCTACACCGGAAAATATTGTGAAATGGCGTTTTCAAAAGGCATCTCTCCA
GGAACAACCGCAGTAGCTGTGCTGTTGACAATCCTCTTGATCGTCGTAATTGGAGCTCTG
GCAATTGCAGGATTCTTCCACTATAGAAGGACCGGCTCCCTTTTGCCTGCTCTGCCCAAG
CTGCCAAGCTTAAGCAGTCTCGTCAAGCCCTCTGAAAATGGGAATGGGGTGACCTTCAGA
TCAGGGGCAGATCTTAACATGGATATTGGAGTGTCTGGTTTTGGACCTGAGACTGCTATT
GACAGGTCAATGGCAATGAGTGAAGACTTTGTCATGGAAATGGGGAAGCAGCCCATAATA
TTTGAAAACCCAATGTACTCAGCCAGAGACAGTGCTGTCAAAGTGGTTCAGCCAATCCAG
GTGACTGTATCTGAAAATGTGGATAATAAGAATTATGGAAGTCCCATAAACCCTTCTGAG
ATAGTTCCAGAGACAAACCCAACTTCACCAGCTGCTGATGGAACTCAGGTGACAAAATGG
AATCTCTTCAAACGAAAATCTAAACAAACTACCAACTTTGAAAATCCAATCTATGCACAG
ATGGAGAACGAGCAAAAGGAAAGTGTTGCTGCGACACCACCTCCATCACCTTCGCTCCCT
GCTAAGCCTAAGCCTCCTTCGAGAAGAGACCCAACTCCAACCTATTCTGCAACAGAAGAC
ACTTTTAAAGACACCGCAAATCTTGTTAAAGAAGACTCTGAAGTATAG

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
U33837

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_9_Locus:
2q24-q31

# Macromolecular_Interacting_Partner_9_SNPs:
rs2075252; rs4668123; rs4667591; rs6716834; rs17848149; rs2228168; rs17848169; rs4667596; rs36082715; rs34291900; rs831043; rs990626; rs2075249; rs11893040; rs830994; rs13397109; rs2241190; rs12622480; rs2302694; rs831042; rs33954745; rs11886219; rs16856476; rs1559014; rs34104660; rs35114151; rs34359765; rs34029982; rs2228170; rs35297090; rs34440349; rs13400618; rs34834388; rs34915742; rs700550; rs2193195; rs741378; rs2544381; rs831004; rs830977; rs2075246; rs830973; rs831003; rs830957; rs831041; rs2075251; rs2300446; rs2673164; rs830971; rs831011; rs1362996; rs830995; rs831007; rs2544377; rs2389589; rs831044; rs2268367; rs831002; rs1816039; rs831010; rs2239591; rs2892802; rs2673170; rs2892803; rs2268370; rs830965; rs2239594; rs831022; rs2075253; rs830997; rs830969; rs2544376; rs1548936; rs2193193; rs1990842; rs1972589; rs2268365; rs2673165; rs2673172; rs6751001; rs2268374; rs2302693; rs10490129; rs2389557; rs4668134; rs6719440; rs2284681; rs2284679; rs10169232; rs4668128; rs2161039; rs831031; rs831036; rs3821125; rs3845731; rs2239589; rs2544380; rs9287911; rs3815572; rs12614394; rs10210408; rs853988; rs3770604; rs2024481; rs2268380; rs9287910; rs11887007; rs830992; rs7598209; rs6433115; rs2268377; rs7592152; rs3821126; rs10169879; rs10204688; rs831037; rs830998; rs6733122; rs6746604; rs982810; rs1421509; rs2247506; rs830956; rs2544374; rs830983; rs831038; rs831040; rs2268368; rs2390793; rs2268379; rs2302695; rs4668136; rs2300447; rs6433109; rs830982; rs6744473; rs831006; rs830999; rs4331469; rs2052297; rs2239597; rs2239590; rs10490132; rs831030; rs11886411; rs831016; rs2239592; rs3926693; rs831005; rs1003456; rs11679947; rs10199676; rs2075248; rs7600336; rs2302692; rs7569236; rs831008; rs2673169; rs10754970; rs3914468; rs2302696; rs6718884; rs831014; rs4668129; rs831009; rs831034; rs830966; rs831025; rs13408445; rs13417486; rs2024480; rs2239600; rs9646731; rs9653235; rs6733111; rs2673177; rs7588584; rs2239598; rs6433114; rs12988804; rs830970; rs830943; rs3944004; rs4140872; rs2216239; rs6730825; rs12615180; rs2544379; rs11687903; rs741376; rs2673173; rs831045; rs4667594; rs3770615; rs10195737; rs831019; rs9283479; rs2268366; rs10177799; rs4287730; rs2300445; rs10930352; rs10198527; rs830967; rs11691854; rs2544378; rs3729573; rs6725805; rs11902491; rs3815678; rs2239596; rs16856592; rs830960; rs7565788; rs4668135; rs2284680; rs2075255; rs10190601; rs3821127; rs7575260; rs3770616; rs831012; rs2544390; rs6433112; rs11889511; rs12692895; rs6759013; rs2544386; rs2673162; rs10490130; rs3815573; rs2239593; rs4667597; rs830964; rs2284675; rs7578722; rs3770636; rs16856796; rs12998030; rs3770630; rs2075247; rs6744155; rs13385160; rs13027608; rs830981; rs4668122; rs6713072; rs7565822; rs990627; rs861239; rs10490131; rs830979; rs6747692; rs16856594; rs11898106; rs831017; rs4667592; rs831033; rs16856843; rs2268376; rs2075254; rs7604111; rs13424066; rs2268373; rs2673167; rs16856530; rs12466068; rs9287913; rs2193194; rs830959; rs2544383; rs2673178; rs10515930; rs2268375; rs13401167; rs12613980; rs2284678; rs2239599; rs11685268; rs16823023; rs12692892; rs2268369; rs830962; rs2544373; rs2544392; rs10515931; rs830976; rs9287912; rs755631; rs10191176; rs2268378; rs16856593; rs16856558; rs4302191; rs6725137; rs16856759; rs830993; rs16856573; rs830972; rs2239595; rs9789747; rs7568568; rs2268372; rs16856802; rs10221870; rs16856748; rs3213759; rs4606889; rs11900233; rs6724600; rs11689553; rs3845732; rs1096456; rs3845730; rs11886318; rs830985; rs9678967; rs17848192; rs6706292; rs10177180; rs9678151; rs2052296; rs11902433; rs10192078; rs2293773; rs11693676; rs10200859; rs16856596; rs830958; rs7557964; rs6754932; rs830963; rs16856823; rs12988055; rs3770607; rs2544387; rs2544385; rs16856642; rs830980; rs831013; rs4667599; rs12622085; rs11886185; rs2239602; rs2284676; rs12151603; rs830984; rs831000; rs7421492; rs2544372; rs10174058; rs2390829; rs3770642; rs11885863; rs3755164; rs10177361; rs3770623; rs7576280; rs13410285; rs831035; rs11886626; rs12478774; rs2389558; rs2673154; rs13388593; rs830978; rs3770624; rs2673176; rs1559013; rs1123905; rs16856842; rs13417389; rs4667593; rs2161038; rs11901315; rs831023; rs2544382; rs830986; rs12615839; rs13389381; rs2673179; rs10191692; rs16856745; rs16856765; rs830948; rs16856600; rs11902300; rs830968; rs6757391; rs3815680; rs13025890; rs700549; rs4497843; rs2075250; rs13424971; rs10165679; rs830991; rs16856638; rs2222020; rs12692894; rs6709670; rs7582071; rs831021; rs12622741; rs2673175; rs13409736; rs3836046; rs13027887; rs831026; rs831046; rs6752222; rs3821128; rs9677474; rs12104494; rs10198558; rs9287914; rs17212087; rs2673163; rs10200740; rs16856731; rs11884342; rs3915725; rs6730118; rs16823029; rs7422871; rs11900411; rs2052298; rs16856840; rs10201691; rs3856427; rs9646777; rs12991585; rs6761244; rs3821124; rs3770628; rs7600757; rs4001547; rs9711887; rs3770613; rs831015; rs830987; rs17280868; rs1006738; rs10153850; rs3770641; rs16856844; rs831029; rs6752778; rs6747214; rs11896574; rs830988; rs12987817; rs16856488; rs13383183; rs831020; rs830990; rs35853478; rs7559094; rs2244407; rs6752012; rs830996; rs16856632; rs11897009; rs830989; rs2222019; rs11888479; rs10199321; rs11893158; rs10169533; rs11896551; rs3770611; rs13011165; rs13013931; rs831001; rs13034796; rs2544369; rs2544384; rs13421129; rs16856618; rs3815679; rs2284677; rs2673151; rs13401581; rs9677453; rs6706290; rs11674531; rs3755166; rs6755801; rs12612683; rs16856847; rs11674973; rs35734447; rs34041086; rs34052957; rs9646779; rs34026778; rs36088625; rs35086590; rs17848140; rs17848188; rs3213760; rs34893088; rs35942532; rs35642533; rs34693334; rs28735621; rs34355135; rs2302691; rs35413340; rs41268689; rs13391626; rs34564141; rs41268685; rs34592807; rs34813328; rs7598640; rs34663643; rs17848184; rs17848143; rs34223099; rs11378293; rs36131094; rs12624237; rs34476611; rs13004829; rs13431061; rs34910249; rs9967871; rs831028; rs10639830; rs12105819; rs11382491; rs10566422; rs17848185; rs17848202; rs13422498; rs35990317; rs12999891; rs34848084; rs13386674; rs35972214; rs35439968; rs10190812; rs1548935; rs11322404; rs34715611; rs6748227; rs34102076; rs36003215; rs11891222; rs13002515; rs3770627; rs34505633; rs34583365; rs13006149; rs11448309; rs17212440; rs3033077; rs9711313; rs13003297; rs11275926; rs2544391; rs4514847; rs1807413; rs10622620; rs1362995; rs34938969; rs35243196; rs13021137; rs12995288; rs35837945; rs17848176; rs10930351; rs5836233; rs3732041; rs36172249; rs10173013; rs13017888; rs13006076; rs10659916; rs35719196; rs12469097; rs4625869; rs35578126; rs34838765; rs34945254; rs5836223; rs2193196; rs830950; rs3770612; rs35517202; rs34861690; rs35889105; rs34407839; rs13005288; rs35583956; rs35448302; rs4249429; rs13396247; rs11371465; rs12476376; rs17848189; rs12986767; rs12476396; rs35842402; rs34379215; rs35311775; rs34401477; rs4001548; rs36154670; rs11301096; rs35472707; rs35200244; rs34912635; rs830947; rs12997360; rs35272876; rs34102451; rs952638; rs11348179; rs2673171; rs3216575; rs13003267; rs13030285; rs10554299; rs3770621; rs34214329; rs3836048; rs35411177; rs831024; rs10547732; rs36122208; rs35786102; rs34543659; rs830944; rs3895006; rs13030290; rs4000805; rs34253557; rs830945; rs34270545; rs10615798; rs13022769; rs35279056; rs34449338; rs10930346; rs3895005; rs11903888; rs35716176; rs3845729; rs12996849; rs10534975; rs34767935; rs34003545; rs28490283; rs5836227; rs7593536; rs13412741; rs34951037; rs35122944; rs11324299; rs34077026; rs4667600; rs7592045; rs35944916; rs34560510; rs2389588; rs13002323; rs17848170; rs3909274; rs5836232; rs17848153; rs17848168; rs11285321; rs11378292; rs831018; rs13004992; rs11900169; rs17848179; rs35371947; rs10170902; rs4613240; rs6709523; rs13415505; rs13386120; rs10607834; rs35845876; rs2544389; rs7419248; rs1548934; rs41268683; rs10567789; rs4347786; rs11407129; rs6147022; rs11333901; rs13003777; rs35629202; rs3831807; rs4668130; rs2544388; rs17848199; rs4000808; rs2673168; rs17848190; rs35918854; rs10188487; rs28450416; rs35863496; rs11283471; rs830949; rs10607809; rs4638759; rs13030894; rs13387618; rs5836222; rs35900697; rs35673463; rs34639881; rs1123904; rs34038476; rs12996875; rs17848175; rs34482409; rs4668124; rs9710881; rs12105427; rs4668127; rs3755165; rs11900170; rs831032; rs13403197; rs11892075; rs34760078; rs16823028; rs41268687; rs830974; rs33994854; rs35913745; rs2239601; rs3216573; rs36190141; rs6721930; rs34375746; rs2544394; rs34430385; rs34379200; rs36016897; rs35809065; rs3216574; rs13025823; rs17848165; rs2544393; rs3836047; rs9678407; rs41416647; rs17848152; rs36029796; rs4000804; rs4577254; rs13004583; rs6719945; rs36198025; rs12997311; rs2673153; rs17848178; rs35192771; rs35444374; rs13035447; rs3083194; rs17848142; rs35235346; rs35710276; rs12104648; rs34840963; rs830961; rs6713797; rs41265945; rs5836221; rs35108325; rs34253860; rs34591586; rs11280955; rs10192423; rs34747016; rs7421121; rs7593537; rs17848183; rs34527748; rs6706284; rs34806803; rs35836996; rs34231545; rs3956575; rs34622768; rs34740272; rs10582057; rs908269; rs10548576; rs34635567; rs3083159; rs7567075; rs35311977; rs36107205; rs34734219; rs36150989; rs35735315; rs11355022; rs13022918; rs35778412; rs36105004; rs3033128; rs13405967; rs11463198; rs34980705; rs830975; rs5836228; rs17848180; rs5836225; rs17848187; rs17214591; rs7563506; rs17848164; rs6741849; rs17848204; rs34624171; rs7593519; rs4264540; rs5836231; rs17848195; rs2892798; rs2673152; rs700551; rs35329615; rs831027; rs35019490; rs13008676; rs35815997; rs34235346; rs3887613; rs13407803; rs13023093; rs35248019; rs34030782; rs36044134; rs1972588; rs3770637; rs9646778; rs13412458; rs12476398; rs831039; rs12617198; rs35994058; rs4668125; rs3821129; rs34187200; rs7567247; rs5836224; rs13022760; rs34950907; rs13415407; rs13005742; rs34822180; rs16856621; rs35862615; rs13029271; rs830942; rs10535757; rs2673180; rs12993779; rs36103732; rs35795863; rs4668137; rs4496304; rs35578054; rs12999602; rs13017872; rs4530335; rs35672541; rs11277444; rs12373565; rs17848161; rs34303563; rs34029789; rs17848191; rs10175901; rs12624226; rs35881194; rs7581268; rs35743956; rs11334523; rs11412926; rs28684083; rs35301449; rs2673174; rs34143252; rs13017879; rs12615478; rs10560196; rs34507563; rs3841894; rs7594986; rs36192333; rs2544375; rs35417732; rs11310711; rs3083236; rs35410668; rs13383187; rs17848182; rs34572668; rs28628065; rs5836230; rs10535758; rs11891223; rs13393740; rs34880654; rs3887612; rs34719462; rs34858999; rs35308196; rs35555656; rs28454851; rs34008706; rs4667595; rs34526338; rs36014271; rs3834152; rs35215525; rs3835381; rs34403096; rs10201911; rs17848205; rs35121806; rs35544194; rs34008226; rs830946; rs17848150; rs34191379; rs34964076; rs35316861; rs36155777; rs831047; rs28612363; rs10561836; rs1331; rs5836220; rs35103265; rs1019334; rs35092200; rs4668138; rs34584070; rs3083261; rs11411235; rs3083240; rs6711662; rs35812045; rs35812271; rs34487091; rs34210907; rs10191750; rs11678216; rs11884346; rs11900073; rs13002827; rs1990702; rs2111187; rs2111188; rs2544371; rs2839723; rs34519055; rs4668121; rs6433106; rs6433107; rs6708113; rs6720740; rs700552; rs830951; rs830955

# Macromolecular_Interacting_Partner_9_General_References:
8706697; 7959795; 8187828; 7768901

# Macromolecular_Interacting_Partner_9_References:
16128811; 16567952; 16760376

End of HMDB00121

Beginning of HMDB00122
# Accession_No:
HMDB00122

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-23 16:38:36

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
D-Glucose

# Description:
Glucose is a monosaccharide containing six carbon atoms and an aldehyde group and is therefore referred to as an aldohexose. The glucose molecule can exist in an open-chain (acyclic) and ring (cyclic) form, the latter being the result of an intramolecular reaction between the aldehyde C atom and the C-5 hydroxyl group to form an intramolecular hemiacetal. In water solution both forms are in equilibrium and at pH 7 the cyclic one is the predominant. Glucose is a primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. In animals glucose arises from the breakdown of glycogen in a process known as glycogenolysis.  Glucose is synthesized in the liver and kidneys from non-carbohydrate intermediates, such as pyruvate and glycerol, by a process known as gluconeogenesis.

# Synonyms:
(+)-Glucose; Anhydrous dextrose; CPC hydrate; Cerelose; Cerelose 2001; Clearsweet 95; Clintose L; Corn sugar; D(+)-Glucose; Dextropur; Dextrose; Dextrosol; Glucodin; Glucolin; Glucose; Goldsugar; Grape sugar; Meritose;  Roferose ST; Staleydex 111; Staleydex 95M; Tabfine 097(HS); Vadex

# Chemical_IUPAC_Name:
(3R,4R,5S,6S)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol

# Chemical_Formula:
C6H12O6

# Chemical_Structure:
tbl_chemical:::HMDB00122_ZOOM.png:::119283200888566548

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00122_THUMB.png:::119283200730538327

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Carbohydrates

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiacetal; primary alcohol; secondary alcohol; 1,2-diol; heterocyclic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
180.06339

# Molecular_Weight_Avg:
180.15588

# Smiles_String_isomeric:
OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O

# Smiles_String_canonical:
OCC1OC(O)C(O)C(O)C1O

# KEGG_Compound_ID:
C00031

# BioCyc_ID:
GLC

# PubChem_CID:
5793

# PubChem_SID:
833240; 838951; 841535; 206675; 7854019; 7847121; 3333; 3587; 148583; 823016; 823057; 3885805; 6435762; 8023353; 7847077; 819111

# OMIM_ID:
232200; 606777; 606824

# Metagene_ID:
CARNITINE TRANSPORTER DEFECT. PRIMARY SYSTEMIC CARNITINE DEFICIENCY: 90; FRIEDREICH ATAXIA: 386; PROPIONIC ACIDEMIA. KETOTIC HYPERGLYCINEMIA (PA): 18; WOLFRAM SYNDROME, DIDMOAD: 376; PERSISTANT HYPERINSULINEMIC HYPOGLYCEMIA OF INFANCY, PHHI: 255; GLUCOGLYCINURIA: 297; 3-METHYL-CROTONYL-GLYCINURIA: 27; 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY: 95; PYRUVATE CARBOXYLASE DEFICIENCY: 109; GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS: 163; CYSTIC FIBROSIS (CF): 103; ISOVALERIC ACIDEMIA: 10; TRIFUNCTIONAL PROTEIN DEFICIENCY: 343; CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY: 342; CHRONIC PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA AND KEARNS-SAYRE SYNDROM: 330; CARNITINE PALMITOYL TRANSFERASE DEFICIENCY (I): 263; GLYCOGENOSIS, TYPE IB: 157; DICARBOXYLIC AMINOACIDURIA. GLUTAMATE-ASPARTATE TRANSPORT DEFECT: 29; HYPOGLYCEMIA, FAMILIAL NEONATAL: 221; MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD): 39; RESPIRATORY CHAIN DEFICIENCIES: 374; GLYCEROL INTOLERANCE SYNDROM: 153; RENAL GLYCOSURIA: 173; SHORT-CHAIN 3-HYDROXYACYL-CoA DEHYDROGENASE DEFICIENCY (SCHAD): 393; S-ADENOSYLHOMOCYSTEINE HYDROLASE DEFICIENCY: 382; ADRENAL HYPOPLASIA. ADDISON DISEASE, X-LINKED: 45; FRUCTOSE INTOLERANCE, HEREDITARY: 129; GLUT-1 DEFICIENCY SYNDROME: 435; FAMILIAL HYPERINSULINEMIA AND HYPERPROINSULINEAMIA WITH MILD DIABETES: 327; 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY: 401; MAPLE SYRUP URINE DISEASE. BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE DEFICIENCY (MSUD): 1; GLYCOGENOSIS, TYPE VI. HERS DISEASE: 166; GALACTOSEMIA: 136; FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY: 128; KETOTIC HYPOGLYCEMIA: 252; PYRUVATE DEHYDROGENASE DEFICIENCY (E3): 333; MALONYL-COA DECARBOXYLASE DEFICIENCY: 28; GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE: 156; SHORT CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD): 40; REYE SYNDROME LIKE MANIFESTATIONS: 303; REYE SYNDROME: 268; BECKWITH-WIEDEMANN SYNDROME. EXOMPHALOS-MAKROGLOSSIA-GIGANTISM SYNDROME: 69; RENAL FANCONI SYNDROME: 112; LONG-CHAIN-3-HYDROXYACYL-CoA DEHYDROGENASE DEFICIENCY (LCHAD): 308; GLYCOGEN SYNTHETASE DEFICIENCY: 172; VERY-LONG-CHAIN ACYL CoA DEHYDROGENASE DEFICIENCY (VLCAD): 392; TYROSINEMIA I: 49; GLUCOSE-GALACTOSE MALABSORPTION: 150; CYSTINOSIS: 104; DIABETES, FETAL EFFECTS FROM MATERNAL: 124; METHYLMALONIC ACIDURIA, cblA TYPE: 328; HYPOADRENOCORTICISM, FAMILIAL: 239; CARNITINE DEFICIENCY, MYOPATHIC: 282; PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 2 (PEPCK2): 262; GLUCAGON DEFICIENCY: 269; GLYCOGENOSIS, TYPE IC: 158; GLYCEROL KINASE DEFICIENCY: 154; OCULOCEREBRORENAL SYNDROME OF LOWE: 344; GLUCOCORTICOID DEFICIENCY, FAMILIAL ISOLATED. MIGEON SYNDROME: 46; 3-METHYLGLUTACONIC ACIDURIA (TYPE I): 23; 21-HYDROXYLASE DEFICIENCY (CYP21): 235; CARNITINE PALMITOYL TRANSFERASE DEFICIENCY (II): 94; GLUTARIC ACIDURIA II: 9; ACTH DEFICIENCY, ISOLATED: 47; NEONATAL HEMOCHROMATOSIS: 367; LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD): 38; ASPHYXIA [DD]: 408; 3-HYDROXY-3-METHYLGLUTARYL-CoA LYASE DEFICIENCY: 4; DIABETES MELLITUS, INSULIN-DEPENDENT: 296; GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE: 164; DIABETES MELLITUS (MODY), NON-INSULIN-DEPENDENT: 117; HUMAN GROWTH HORMONE DEFICIENCY: 270; EXERCISE-INDUCED-HYPERINSULINSM [EIHI]: 478; BETA-KETOTHIOLASE DEFICIENCY: 5

# BiGG_ID:
33582

# Wikipedia_ID:
Dextrose

# METLIN_ID:
133

# Ref_ID:
16417449; 10218738; 15196417; 1008588; 16736954; 15627241; 9933021; 9693263; 6936873; 805737; 1828739; 3094400; 1931558; 7299995; 3580023; 6810706; 3153324; 14454131; 6321058; 3666622

# ChEBI_ID:
17634

# CAS_Registry_Number:
50-99-7

# InChI:
InChI=1/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1

# Synthesis_Reference:
 Journal of the American Chemical Society  (1935),  57  2204-8

# Melting_Point:
146-150 oC

# Melting_Point_predicted:
106.2 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1200.0 mg/mL [MULLIN,JW (1972)]

# H2O_Solubility_Predicted:
782.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-3.24 [SANGSTER (1994)]

# LogP_predicted:
-2.57 [Predicted by ALOGPS]; -2.3 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Glucose.pdf:::1132562202732483088

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::D-Glucose.mol:::11659404302238986

# SDF_File_[Text]:
tbl_chemical:::HMDB00122.sdf:::1192832003648973

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00122.pdb:::11928320059221292

# PDB_ID:
1A47

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::50-99-7presatC.gif:::114227353137122030

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041106_P00_04_IS_1DP_PRESAT_1.zip:::114460782976588039

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041106_P00_04_IS_1DP_Assigned.png:::114660462121015102

# C_NMR_Spectra:
tbl_cnmr:::041106_P00_04_IS_1DC_67.jpg:::114168459421495755

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041106_P00_04_IS_1DC_67.zip:::114168459418115763

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041106_P00_04_IS_1DC_67_Assigned.jpg:::114488147646918487

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041106_P00_04_IS_2DHSQC_219.jpg:::114495823641892816

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041106_P00_04_IS_2DHSQC_219.zip:::114495823642857535

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041106_P00_04_IS_2DHSQC_219_Assigned.jpg:::115955810165672645

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Glucose.gif:::1132732110796568665

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00122_peaks.txt:::1156309557547324769

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Glucose_C.gif:::113273769012422477

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00122_peaks.txt:::1156310747654291916

# Mass_Spectrum:
tbl_chemical:::HMDB00122.gif:::117253144073896121

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP); endoplasmic reticulum; Extracellular; golgi apparatus; lysosome

# Tissue_Location:
Adipose Tissue; Adrenal Cortex; Adrenal Gland; Adrenal Medulla; Beta Cell; Bladder; Brain; Brain Plaques; Epidermis; Eye Lens; Fetus; Fibroblasts; Gonads; Gut; Intestine; Kidney; Liver; Lung; Mouth; Muscle; Myelin; Nerves; Neurons; Pancreas; Placenta; Pla

# deuterated:
No

# Biofluid_Location:
Blood; Breast Milk; CSF; Saliva; Urine

# Concentration_[Normal]:
Urine	> 0.65	umol/mmol_creatinine	Adult:>18_yrs_old	N/A	Normal	6321058
Blood	12000.0 +/- 4440.0	umol/L	Children:1-13_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	5300 (4900-5700)	umol/L	Adult:>18_yrs_old	Both	Normal	10218738
Blood	4750.0 +/- 184.0	uM	Newborn:0-30_days_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	2200.0 (1100.0-3300.0)	uM	Newborn:0-30_days_old	Both	Normal	Tietz Clinical Guide to Laboratory Tests, 4th. Ed. 2006 Elsevier
Blood	4440.0 +/- 370.0	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	4570.0 +/- 411.0	uM	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	2750.0 (2200.0-3300.0)	uM	Newborn:0-30_days_old	Both	Normal	Tietz Clinical Guide to Laboratory Tests, 4th. Ed. 2006 Elsevier
Blood	4470.0 +/- 346.0	uM	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	4450.0 (3300.0 - 5600.0)	uM	Children:1-13_yrs_old	Both	Normal	Tietz Clinical Guide to Laboratory Tests, 4th. Ed. 2006 Elsevier
Blood	5450.0 (4200.0 - 6700.0)	uM	Elderly:>65_yrs_old	Both	Normal	Tietz Clinical Guide to Laboratory Tests, 4th. Ed. 2006 Elsevier
Cerebrospinal_Fluid(CSF)	7236.0 +/- 3598.0	uM	Adult:>18_yrs_old	Both	Normal	HMP Experimental
Cerebrospinal_Fluid(CSF)	5390.0 +/- 1650.0	umol/L	Adult:>18_yrs_old	N/A	Normal	1931558
Cerebrospinal_Fluid(CSF)	1720.0 (1560.0-1880.0)	umol/L	Adult:>18_yrs_old	Both	Normal	15627241
Saliva	>10	umol/L	Adult:>18_yrs_old	Both	Normal	3666622
Breast_Milk	4500.0+/- 100.0	uM	Adult:>18_yrs_old	Female	Normal	16456418 


# Concentration_[Abnormal]:
Urine	19700.0	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Diabetes	6321058
Urine	79600.0 (68300.0-90900.0)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Diabetic ketosis	6810706
Urine	79.6	umol/mmol_creatinine	Adult:>18_yrs_old	N/A	Diabetic ketosis	6810706
Cerebrospinal_Fluid(CSF)	3700.0 (3200.0-4200.0)	umol/L	Adult:>18_yrs_old	Both	Dementia of Alzheimer type (DAT)	9693263


# Associated_Disorders:
2-Ketoglutarate Dehydrogenase Complex Deficiency; 21-Hydroxylase Deficiency (CYP21); 3-Beta-Hydroxysteroid Dehydrogenase Deficiency; 3-Hydroxy-3-Methylglutaric Acidemia; 3-Methyl-Crotonyl-Glycinuria; 3-Methylglutaconic Aciduria (Type I); ACTH Deficiency, Isolated; Addison's Disease; Adenosylcobalamin Deficiency (CBLA, CBLB); Adrenal Hypoplasia; Amylopectinosis; Anderson Disease; Asphyxia [DD]; Beckwith-Wiedemann Syndrome; Beta-Ketothiolase Deficiency; Branched-Chain Alpha-Keto Acid Dehydrogenase Deficiency (MSUD); Cardiogenic Shock; Carnitine Deficiency, Myopathic; Carnitine Palmitoyl Transferase Deficiency (I); Carnitine Palmitoyl Transferase Deficiency (II); Carnitine Transporter Defect; Carnitine-Acylcarnitine Translocase Deficiency; Chronic Progressive External Ophthalmoplegia and Kearns-Sayre Syndrome; Cystic Fibrosis (CF); Cystinosis; Dementia of Alzheimer type (DAT); Diabetes; Diabetes, Fetal Effects From Maternal; Diabetic ketosis; Dicarboxylic Aminoaciduria; Disc herniation; Exercise-Induced-Hyperinsulinsm (EIHI); Exomphalos-Makroglossia-Gigantism Syndrome; Familial Hyperinsulinemia and Hyperproinsulineamia with Mild Diabetes; Friedreich Ataxia; Fructose Intolerance, Hereditary; Fructose-1,6-Diphosphatase Deficiency; Galactosemia; Gallstone Pancreatitis; Glucagon Deficiency; Glucocorticoid Deficiency, Familial Isolated; Glucoglycinuria; Glucose-galactose Malabsorption; Glutamate-Aspartate Transport Defect; Glutaric Aciduria II; Glycerol Intolerance Syndrome; Glycerol Kinase Deficiency; Glycogen Synthetase Deficiency; Glycogenosis Type III (Cori Disease, Debrancher Glycogenosis); Glycogenosis, Type IA; Glycogenosis, Type IB; Glycogenosis, Type IC; Glycogenosis, Type IV; Glycogenosis, Type VI; Hers Disease; Human Growth Hormone Deficiency; Hyperglycemia; Hypoadrenocorticism, Familial; Hypoglycemia, Familial Neonatal; Isovaleric Acidemia; Ketotic Hyperglycinemia; Ketotic Hypoglycemia; Kidney Damage; Long Chain Acyl-Coa Dehydrogenase Deficiency (LCAD); Long-Chain-3-Hydroxyacyl-Coa Dehydrogenase Deficiency (LCHAD); Malonyl-Coa Decarboxylase Deficiency; Maple Syrup Urine Disease; Medium Chain Acyl-Coa Dehydrogenase Deficiency (MCAD); Migeon Syndrome; Neonatal Hemochromatosis; Oculocerebrorenal Syndrome OF LOWE; Persistant Hyperinsulinemic Hypoglycemia of Infancy (PHHI); Phosphoenolpyruvate Carboxykinase Deficiency 2 (PEPCK2); Primary Systemic Carnitine Deficiency; Propionic Acidemia; Pyruvate Carboxylase Deficiency; Pyruvate Dehydrogenase Deficiency (E3); Renal Fanconi Syndrome; Respiratory Chain Deficiencies; Reye Syndrome; Reye Syndrome Like Manifestations; Short Chain Acyl-Coa Dehydrogenase Deficiency (SCAD); Short-Chain 3-Hydroxyacyl-Coa Dehydrogenase Deficiency (SCHAD); Spinal stenosis; Trifunctional Protein Deficiency; Tyrosinemia I; Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCADD); Von Gierke Disease; Wolfram Syndrome (DIDMOAD)

# Pathway_Names:
D-Arginine and D-ornithine metabolism;Pyruvate metabolism;Glyoxylate and dicarboxylate metabolism;Alanine and aspartate metabolism

# Pathway_Images:
;;;Aspartate_and_Alanine_metabolism.jpg

# KEGG_Images:
map00472;map00620;map00630;map00252

# Pathway_Graphs:
;;;Aspartate_and_Alanine_metabolism_Graph.jpg

# Pathway_SBMLs:
;;;Aspartate_and_Alanine_metabolism.xml

# Metabolic_Enzyme_1_ID:
5438

# Metabolic_Enzyme_1_Name:
D-amino-acid oxidase

# Metabolic_Enzyme_1_Synonyms:
DAMOX; DAO; DAAO

# Metabolic_Enzyme_1_Gene_Name:
DAO

# Metabolic_Enzyme_1_Protein_Sequence:
>Daminoacid oxidase
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPN
NPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPR
ELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVN
CTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGG
IFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGP
SNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL

# Metabolic_Enzyme_1_Number_of_Residues:
347

# Metabolic_Enzyme_1_Molecular_Weight:
39475

# Metabolic_Enzyme_1_Theoretical_pI:
6.84

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
Function:  D-amino-acid oxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids

# Metabolic_Enzyme_1_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00472  D-Arginine and D-ornithine metabolism

# Metabolic_Enzyme_1_Reaction:
a D-amino acid + H2O + O2 = a 2-oxo acid + ammonia + H2O2

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01266:DAO

# Metabolic_Enzyme_1_Signals:
1-16

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.4.3.3

# Metabolic_Enzyme_1_GenBank_ID_Protein:
30446

# Metabolic_Enzyme_1_SwissProt_ID:
OXDA_HUMAN (P14920)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
DAO

# Metabolic_Enzyme_1_Geneatlas_id:
DAO

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2671

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_1_Gene_Sequence:
>1044 bp
ATGCGTGTGGTGGTGATTGGAGCAGGAGTCATCGGGCTGTCCACCGCCCTCTGCATCCAT
GAGCGCTACCACTCAGTCCTGCAGCCACTGCACATAAAGGTCTACGCGGACCGCTTCACC
CCACTCACCACCACCGACGTGGCTGCCGGCCTCTGGCAGCCCTACCTTTCTGACCCCAAC
AACCCACAGGAGGCGGACTGGAGCCAACAGACCTTTGACTATCTCCTGAGCCATGTCCAT
TCTCCCAACGCTGAAAACCTGGGCCTGTTCCTAATCTCGGGCTACAACCTCTTCCATGAA
GCCATTCCGGACCCTTCCTGGAAGGACACAGTTCTGGGATTTCGGAAGCTGACCCCCAGA
GAGCTGGATATGTTCCCAGATTACGGCTATGGCTGGTTCCACACAAGCCTAATTCTGGAG
GGAAAGAACTATCTACAGTGGCTGACTGAAAGGTTAACTGAGAGGGGAGTGAAGTTCTTC
CAGCGGAAAGTGGAGTCTTTTGAGGAGGTGGCAAGAGAAGGCGCAGACGTGATTGTCAAC
TGCACTGGGGTATGGGCTGGGGCGCTACAACGAGACCCCCTGCTGCAGCCAGGCCGGGGG
CAGATCATGAAGGTGGACGCCCCTTGGATGAAGCACTTCATTCTCACCCATGACCCAGAG
AGAGGCATCTACAATTCCCCGTACATCATCCCAGGGACCCAGACAGTTACTCTTGGAGGC
ATCTTCCAGTTGGGAAACTGGAGTGAACTAAACAATATCCAGGACCACAACACCATTTGG
GAAGGCTGCTGCAGACTGGAGCCCACACTGAAGAATGCAAGAATTATTGGTGAAGCAACT
GGCTTCCGGCCAGTACGCCCCCAGATTCGGCTAGAAAGAGAACAGCTTCGCACTGGACCT
TCAAACACAGAGGTCATCCACAACTATGGCCATGGAGGCTACGGGCTCACCATCCACTGG
GGATGTGCCCTGGAGGCAGCCAAGCTCTTTGGGAGAATCCTGGAAGAAAAGAAATTGTCC
AGAATGCCACCATCCCACCTCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X13227

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_1_Locus:
12q24

# Metabolic_Enzyme_1_SNPs:
rs7980427; rs2111902; rs7977762; rs4964767; rs17041020; rs12579920; rs4964766; rs2070588; rs11114083; rs9706062; rs2070586; rs4964765; rs7316889; rs2070585; rs2070587; rs1808351; rs11830725; rs3741775; rs11114086; rs11114085; rs6539458; rs3918347; rs6539460; rs10861974; rs4964281; rs11837302; rs3918346; rs7967441; rs11114084; rs11114087; rs12426462; rs6539459; rs6539462; rs2302882; rs3741774; rs4964280; rs17041050; rs17041074; rs9669254; rs3825251; rs12229954; rs6539461; rs17041058; rs7962665; rs17041040; rs7975723; rs10778658; rs3741776; rs17041039; rs7302245; rs4623951; rs10861973; rs7965821; rs35388422; rs4262766; rs35658778; rs4644682; rs35550859; rs34135554; rs11415772; rs762451; rs34780883; rs11417050; rs1053875; rs3741773; rs35481176; rs11611767; rs10689951; rs10696805; rs4989798; rs35363883; rs28868909; rs12810412; rs11301485; rs34552650; rs35324225; rs7134038; rs36013571; rs7967357; rs35521446; rs4989799; rs35572480; rs36104885; rs9668314; rs5800839; rs12811324; rs11420034; rs11335673; rs11464907; rs11402329; rs11356161; rs9668327; rs7138366; rs35258241; rs34666571; rs35167645; rs10599880; rs35681690; rs12810212; rs10778659; rs12830695; rs35356685; rs36032329; rs11114080; rs11114081; rs34178394; rs10861977; rs1129027; rs12308912; rs4964762; rs4964770; rs7294679; rs7308400; rs7958090

# Metabolic_Enzyme_1_General_References:
2901986; 1356107

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5628

# Metabolic_Enzyme_2_Name:
Glyoxylate reductase/hydroxypyruvate reductase

# Metabolic_Enzyme_2_Synonyms:
Not Available

# Metabolic_Enzyme_2_Gene_Name:
GRHPR

# Metabolic_Enzyme_2_Protein_Sequence:
>Glyoxylate reductase/hydroxypyruvate reductase
MRPVRLMKVFVTRRIPAEGRVALARAADCEVEQWDSDEPIPAKELERGVAGAHGLLCLLS
DHVDKRILDAAGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLL
TTCRRLPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRF
LYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVF
INISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIGSATHR
TRNTMSLLAANNLLAGLRGEPMPSELKL

# Metabolic_Enzyme_2_Number_of_Residues:
328

# Metabolic_Enzyme_2_Molecular_Weight:
35669

# Metabolic_Enzyme_2_Theoretical_pI:
7.44

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  L-serine metabolism
Process:  L-serine biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities

# Metabolic_Enzyme_2_Pathway:
map00620  Pyruvate metabolism;
 map00630  Glyoxylate and dicarboxylate metabolism

# Metabolic_Enzyme_2_Reaction:
glycolate + NADP+ = glyoxylate + NADPH + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00389:2-Hacid_dh;
PF02826:2-Hacid_dh_C

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.1.79

# Metabolic_Enzyme_2_GenBank_ID_Protein:
6002730

# Metabolic_Enzyme_2_SwissProt_ID:
GRHPR_HUMAN (Q9UBQ7)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
GRHPR

# Metabolic_Enzyme_2_Geneatlas_id:
GRHPR

# Metabolic_Enzyme_2_hgnc_id:
HGNC:4570

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>987 bp
ATGAGACCGGTGCGACTCATGAAGGTGTTCGTCACCCGCAGGATACCCGCCGAGGGTAGG
GTCGCGCTCGCCCGGGCGGCAGACTGTGAGGTGGAGCAGTGGGACTCGGATGAGCCCATC
CCTGCCAAGGAGCTAGAGCGAGGTGTGGCGGGGGCCCACGGCCTGCTCTGCCTCCTCTCC
GACCACGTGGACAAGAGGATCCTGGATGCTGCAGGGGCCAATCTCAAAGTCATCAGCACC
ATGTCTGTGGGCATCGACCACTTGGCTTTGGATGAAATCAAGAAGCGTGGGATCCGAGTT
GGCTACACCCCAGATGTCCTGACAGATACCACCGCCGAACTCGCAGTCTCCCTGCTACTT
ACCACCTGCCGCCGGTTGCCGGAGGCCATCGAGGAAGTGAAGAATGGTGGCTGGACCTCG
TGGAAGCCCCTCTGGCTGTGTGGCTATGGACTCACGCAGAGCACTGTCGGCATCATCGGG
CTGGGGCGCATAGGCCAGGCCATTGCTCGGCGTCTGAAACCATTCGGTGTCCAGAGATTT
CTGTACACAGGGCGCCAGCCCAGGCCTGAGGAAGCAGCAGAATTCCAGGCAGAGTTTGTG
TCTACCCCTGAGCTGGCTGCCCAATCTGATTTCATCGTCGTGGCCTGCTCCTTAACACCT
GCAACCGAGGGACTCTGCAACAAGGACTTCTTCCAGAAGATGAAGGAAACAGCTGTGTTC
ATCAACATCAGCAGGGGCGACGTCGTAAACCAGGACGACCTGTACCAGGCCTTGGCCAGT
GGTAAGATTGCAGCTGCTGGACTGGATGTGACGAGCCCAGAACCACTGCCTACAAACCAC
CCTCTCCTGACCCTGAAGAACTGTGTGATTCTGCCCCACATTGGCAGTGCCACCCACAGA
ACCCGCAACACCATGTCCTTGTTGGCAGCTAACAACTTGCTGGCTGGCCTGAGAGGGGAG
CCGATGCCTAGTGAACTCAAGCTGTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF134895

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_2_Locus:
9q12

# Metabolic_Enzyme_2_SNPs:
rs12002324; rs309458; rs309461; rs2768659; rs2736664; rs2768662; rs7867764; rs309455; rs309459; rs1887454; rs309453; rs2768658; rs12552734; rs309452; rs309460; rs309457; rs2235096; rs10973333; rs309456; rs309462; rs17885933; rs17411423; rs12683277; rs10973336; rs2768657; rs10973334; rs309454; rs4472607; rs7856656; rs4878690; rs7872991; rs10973329; rs7853540; rs7857159; rs10973327; rs10973328; rs7872720; rs6476631; rs7853526; rs11546642; rs35975284; rs11546644; rs1057507; rs3198078; rs2736669; rs2736662; rs2768660; rs2736670; rs35891798; rs2736673; rs34288288; rs41278295; rs41298174; rs2736665; rs2736660; rs2736667; rs10973335; rs2736671; rs2736661; rs41303225; rs16934118; rs2736663; rs1807410; rs35417895; rs2736666; rs2736674; rs10643023; rs2736668; rs34302950; rs11345501; rs2736672; rs309451; rs13299681; rs10973331; rs10679296; rs34280344; rs10973332; rs35292277; rs34688490; rs34632389; rs10643132; rs5897688; rs927929; rs34510989; rs10814535; rs10973324; rs10973338; rs10973339; rs10973340; rs11793053; rs12348205; rs13300415; rs17411255; rs17502738; rs1802995; rs2840246; rs309450; rs35680410; rs35720597; rs7022431; rs7031029; rs7038960; rs7039333

# Metabolic_Enzyme_2_General_References:
10524214; 10484776; 10679197

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5633

# Metabolic_Enzyme_3_Name:
Alanine--glyoxylate aminotransferase 2, mitochondrial precursor

# Metabolic_Enzyme_3_Synonyms:
(R-3-amino-2-methylpropionate--pyruvate transaminase; AGT 2; Beta-alanine-pyruvate aminotransferase; Beta- ALAAT II; D-AIBAT

# Metabolic_Enzyme_3_Gene_Name:
AGXT2

# Metabolic_Enzyme_3_Protein_Sequence:
>Alanineglyoxylate aminotransferase 2, mitochondrial precursor
MTLIWRHLLRPLCLVTSAPRILEMHPFLSLGTSRTSVTKLSLHTKPRMPPCDFMPERYQS
LGYNRVLEIHKEHLSPVVTAYFQKPLLLHQGHMEWLFDAEGSRYLDFFSGIVTVSVGHCH
PKVNAVAQKQLGRLWHTSTVFFHPPMHEYAEKLAALLPEPLKVIFLVNSGSEANELAMLM
ARAHSNNIDIISFRGAYHGCSPYTLGLTNVGTYKMELPGGTGCQPTMCPDVFRGPWGGSH
CRDSPVQTIRKCSCAPDCCQAKDQYIEQFKDTLSTSVAKSIAGFFAEPIQGVNGVVQYPK
GFLKEAFELVRARGGVCIADEVQTGFGRLGSHFWGFQTHDVLPDIVTMAKGIGNGFPMAA
VITTPEIAKSLAKCLQHFNTFGGNPMACAIGSAVLEVIKEENLQENSQEVGTYMLLKFAK
LRDEFEIVGDVRGKGLMIGIEMVQDKISCRPLPREEVNQIHEDCKHMGLLVGRGSIFSQT
FRIAPSMCITKPEVDFAVEVFRSALTQHMERRAK

# Metabolic_Enzyme_3_Number_of_Residues:
514

# Metabolic_Enzyme_3_Molecular_Weight:
57157

# Metabolic_Enzyme_3_Theoretical_pI:
7.91

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
L-alanine + glyoxylate = pyruvate + glycine

# Metabolic_Enzyme_3_Pathway:
map00252  Alanine and aspartate metabolism;
 map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_3_Reaction:
L-alanine + glyoxylate = pyruvate + glycine

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00202:Aminotran_3

# Metabolic_Enzyme_3_Signals:
1-24

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.6.1.44;EC 2.6.1.40

# Metabolic_Enzyme_3_GenBank_ID_Protein:
12406973

# Metabolic_Enzyme_3_SwissProt_ID:
AGT2_HUMAN (Q9BYV1)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
AGXT2

# Metabolic_Enzyme_3_Geneatlas_id:
AGXT2

# Metabolic_Enzyme_3_hgnc_id:
HGNC:14412

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion (Potential)

# Metabolic_Enzyme_3_Gene_Sequence:
>1545 bp
ATGACTCTAATCTGGAGACATTTGCTGAGACCCTTGTGCCTGGTCACTTCCGCTCCCAGG
ATCCTTGAGATGCATCCTTTCCTGAGCCTAGGTACTTCCCGGACATCAGTAACCAAGCTC
AGTCTTCATACAAAGCCCAGAATGCCTCCATGTGACTTCATGCCTGAAAGATACCAGTCC
CTTGGCTACAACCGTGTCCTGGAAATCCACAAGGAACATCTTTCTCCTGTGGTGACGGCA
TATTTCCAGAAACCCCTGCTGCTCCACCAGGGGCACATGGAGTGGCTCTTTGATGCTGAA
GGAAGCAGATACCTGGATTTCTTTTCCGGGATTGTTACTGTCAGTGTTGGCCATTGCCAC
CCAAAGGTGAATGCAGTGGCACAAAAGCAGCTCGGCCGCCTGTGGCATACAAGCACCGTC
TTCTTCCACCCTCCAATGCATGAATATGCAGAGAAGCTTGCCGCACTTCTTCCTGAGCCT
CTTAAGGTCATTTTCTTGGTGAACAGTGGCTCAGAAGCCAATGAGCTGGCCATGCTGATG
GCCAGGGCGCACTCAAACAACATAGACATCATTTCTTTCAGAGGAGCCTACCATGGATGC
AGTCCTTACACACTTGGCTTGACAAACGTAGGGACCTACAAGATGGAACTCCCTGGTGGG
ACAGGTTGCCAACCAACAATGTGTCCAGATGTTTTTCGTGGCCCTTGGGGAGGAAGCCAC
TGTCGAGATTCTCCAGTGCAAACAATCAGGAAGTGCAGCTGTGCACCAGACTGCTGCCAA
GCTAAAGATCAGTATATTGAGCAATTCAAAGATACGCTGAGCACATCTGTGGCCAAGTCA
ATTGCTGGATTTTTCGCAGAACCTATTCAAGGTGTGAATGGAGTTGTCCAGTACCCAAAG
GGGTTTCTAAAGGAAGCCTTTGAGCTGGTGCGAGCAAGGGGAGGCGTGTGCATTGCAGAT
GAAGTGCAGACAGGATTTGGAAGGTTGGGCTCTCACTTCTGGGGCTTCCAAACCCACGAT
GTCCTGCCTGACATTGTCACCATGGCTAAAGGGATTGGGAATGGCTTTCCCATGGCAGCA
GTCATAACCACTCCAGAGATTGCCAAATCTTTGGCGAAATGCCTGCAGCACTTCAACACC
TTTGGAGGGAACCCCATGGCCTGTGCCATTGGATCTGCTGTGCTTGAGGTGATTAAAGAA
GAAAATCTACAGGAAAACAGTCAAGAAGTTGGGACCTACATGTTACTAAAGTTTGCTAAG
CTGCGGGATGAATTTGAAATTGTTGGAGACGTCCGAGGCAAAGGTCTCATGATAGGCATA
GAAATGGTGCAGGATAAGATAAGCTGTCGGCCTCTTCCCCGTGAAGAAGTAAATCAGATC
CATGAGGACTGCAAGCACATGGGACTCCTCGTTGGCAGAGGCAGCATTTTTTCTCAGACA
TTTCGCATTGCGCCCTCAATGTGCATCACTAAACCAGAAGTTGATTTTGCAGTAGAAGTA
TTTCGTTCTGCCTTAACCCAACACATGGAAAGAAGAGCTAAGTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
AJ292204

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
Not Available

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
6067

# Metabolic_Enzyme_4_Name:
Hydroxyacid oxidase 1

# Metabolic_Enzyme_4_Synonyms:
HAOX1; Glycolate oxidase; GOX

# Metabolic_Enzyme_4_Gene_Name:
HAO1

# Metabolic_Enzyme_4_Protein_Sequence:
>Hydroxyacid oxidase 1
MLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAET
DLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAE
AGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQ
LRMKNFETSTLSFSPEENFGDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILR
GDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDV
LKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLV
RKNPLAVSKI

# Metabolic_Enzyme_4_Number_of_Residues:
370

# Metabolic_Enzyme_4_Molecular_Weight:
40925

# Metabolic_Enzyme_4_Theoretical_pI:
8.29

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids

# Metabolic_Enzyme_4_Pathway:
map00630  Glyoxylate and dicarboxylate metabolism

# Metabolic_Enzyme_4_Reaction:
(S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01070:FMN_dh

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.1.3.15

# Metabolic_Enzyme_4_GenBank_ID_Protein:
7530485

# Metabolic_Enzyme_4_SwissProt_ID:
HAOX1_HUMAN (Q9UJM8)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
HAO1

# Metabolic_Enzyme_4_Geneatlas_id:
HAO1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:4809

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_4_Gene_Sequence:
>1113 bp
ATGCTCCCCCGGCTAATTTGTATCAATGATTATGAACAACATGCTAAATCAGTACTTCCA
AAGTCTATATATGACTATTACAGGTCTGGGGCAAATGATGAAGAAACTTTGGCTGATAAT
ATTGCAGCATTTTCCAGATGGAAGCTGTATCCAAGGATGCTCCGGAATGTTGCTGAAACA
GATCTGTCGACTTCTGTTTTAGGACAGAGGGTCAGCATGCCAATATGTGTGGGGGCTACG
GCCATGCAGCGCATGGCTCATGTGGACGGCGAGCTTGCCACTGTGAGAGCCTGTCAGTCC
CTGGGAACGGGCATGATGTTGAGTTCCTGGGCCACCTCCTCAATTGAAGAAGTGGCGGAA
GCTGGTCCTGAGGCACTTCGTTGGCTGCAACTGTATATCTACAAGGACCGAGAAGTCACC
AAGAAGCTAGTGCGGCAGGCAGAGAAGATGGGCTACAAGGCCATATTTGTGACAGTGGAC
ACACCTTACCTGGGCAACCGTCTGGATGATGTGCGTAACAGATTCAAACTGCCGCCACAA
CTCAGGATGAAAAATTTTGAAACCAGTACTTTATCATTTTCTCCTGAGGAAAATTTTGGA
GACGACAGTGGACTTGCTGCATATGTGGCTAAAGCAATAGACCCATCTATCAGCTGGGAA
GATATCAAATGGCTGAGAAGACTGACATCATTGCCAATTGTTGCAAAGGGCATTTTGAGA
GGTGATGATGCCAGGGAGGCTGTTAAACATGGCTTGAATGGGATCTTGGTGTCGAATCAT
GGGGCTCGACAACTCGATGGGGTGCCAGCCACTATTGATGTTCTGCCAGAAATTGTGGAG
GCTGTGGAAGGGAAGGTGGAAGTCTTCCTGGACGGGGGTGTGCGGAAAGGCACTGATGTT
CTGAAAGCTCTGGCTCTTGGCGCCAAGGCTGTGTTTGTGGGGAGACCAATCGTTTGGGGC
TTAGCTTTCCAGGGGGAGAAAGGTGTTCAAGATGTCCTCGAGATACTAAAGGAAGAATTC
CGGTTGGCCATGGCTCTGAGTGGGTGCCAGAATGTGAAAGTCATCGACAAGACATTGGTG
AGGAAAAATCCTTTGGCCGTTTCCAAGATCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF244134

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_4_Locus:
20p12

# Metabolic_Enzyme_4_SNPs:
rs33931524; rs3747926; rs2243433; rs1569454; rs2017494; rs2423325; rs1883209; rs2235241; rs941425; rs2294301; rs2142696; rs2250943; rs2247586; rs2142697; rs2294300; rs2423336; rs1540901; rs2423326; rs6086284; rs2235237; rs6055364; rs1883210; rs2423334; rs2235243; rs6108081; rs8119321; rs941426; rs8113842; rs6133511; rs7260781; rs2235250; rs2254923; rs6055372; rs2255183; rs2254801; rs2294304; rs2235240; rs12625899; rs6117980; rs6055390; rs7266916; rs2423322; rs2327003; rs6516330; rs6055375; rs6055400; rs1883211; rs12710332; rs6055391; rs6055398; rs1028310; rs2423335; rs2247663; rs1983560; rs12625217; rs2250429; rs2205817; rs2423324; rs6108080; rs4140559; rs2294306; rs1569453; rs6118004; rs2247673; rs2423330; rs2142700; rs16994127; rs6086276; rs2223276; rs1983559; rs6038976; rs12625244; rs8119185; rs7266518; rs2294298; rs2235242; rs2423328; rs6086287; rs6086282; rs2235245; rs6077285; rs11907636; rs3930510; rs2423327; rs6086279; rs2235244; rs7266199; rs2205818; rs11905753; rs2294299; rs6055370; rs6140463; rs8118176; rs2142701; rs7269011; rs6055367; rs6117978; rs16994181; rs12479800; rs17332292; rs7271299; rs8119175; rs6055378; rs2235248; rs8124232; rs2205821; rs2423331; rs6117982; rs6038977; rs2235247; rs11907197; rs2142698; rs3938382; rs2250928; rs6055396; rs17423211; rs6055366; rs2423333; rs2247585; rs2235246; rs11698761; rs13038486; rs2235238; rs16994134; rs6133515; rs2223275; rs13040468; rs6108079; rs8114834; rs6140461; rs7361466; rs2235239; rs13041645; rs6055387; rs2294307; rs2294305; rs2223274; rs2281026; rs4140560; rs2250567; rs6086290; rs6140468; rs12624817; rs9753568; rs6133516; rs6140469; rs6055363; rs6140467; rs16994212; rs12625575; rs6055362; rs17424349; rs6117976; rs12624982; rs34249643; rs6118003; rs6038973; rs6140460; rs2294302; rs35708943; rs35500410; rs3215458; rs3830727; rs6140455; rs2272813; rs34475991; rs33971182; rs6038975; rs6117993; rs10610494; rs6140458; rs11475177; rs34245391; rs11469680; rs7345525; rs3817774; rs6118010; rs35108815; rs35848853; rs6055395; rs2423329; rs5840240; rs6117987; rs6055399; rs35930462; rs6086277; rs10693627; rs35338069; rs11468202; rs34416691; rs34473022; rs6055371; rs11475130; rs11329950; rs10630953; rs6140464; rs6086272; rs13045772; rs34671595; rs6117997; rs11473859; rs6055392; rs10585629; rs35105944; rs36037568; rs6118000; rs11467510; rs11479131; rs35974266; rs11468404; rs11438122; rs8122709; rs6108076; rs2294303; rs3215459; rs11478854; rs6118009; rs7267272; rs6117985; rs2205816; rs11476410; rs11483714; rs11484347; rs28546842; rs6140459; rs6055377; rs6086274; rs34236287; rs28599710; rs35669859; rs6055379; rs6118014; rs34880394; rs34334468; rs6117990; rs6147282; rs11477740; rs2205820; rs6118013; rs6140465; rs6117998; rs6086268; rs6077291; rs3215460; rs34412020; rs6117983; rs6086280; rs7266585; rs10590340; rs13039013; rs35798481; rs6117988; rs6086271; rs34625451; rs6038979; rs11697565; rs6055374; rs6077290; rs6117999; rs6055393; rs6086269; rs35385638; rs33934623; rs35526555; rs2142699; rs6117984; rs34344737; rs35478783; rs6108077; rs34672598; rs11480593; rs2205819; rs16994117; rs35960606; rs6140466; rs13045696; rs35264555; rs11470783; rs3215457; rs6117991; rs6055373; rs6055369; rs6118002; rs5840241; rs6086270; rs11476936; rs35845521; rs10543894; rs6118012; rs6140457; rs28396241; rs34395726; rs11470902; rs11477909; rs11468259; rs35502451; rs3215461; rs7263368; rs4816026; rs6055384; rs6117989; rs11480990; rs11699240; rs6118001; rs34357188; rs34819349; rs6055397; rs6055394; rs6077286; rs6118007; rs6140462; rs6055365; rs11358812; rs7268911; rs7269597; rs11478920; rs6117995; rs6117992; rs6108078; rs7347181; rs11481371; rs8123185; rs2423332; rs34931508; rs6086278; rs35167351; rs34198710; rs6055388; rs6055368; rs6117981; rs6117986; rs2235249; rs11475213; rs35267240; rs34439496; rs8182639; rs34738743; rs34048209; rs6086267; rs6055361; rs6038972; rs7270706; rs11699153; rs6086266; rs35365849; rs2142702; rs4366971; rs6038970; rs6038971; rs6055351; rs6055354; rs6055357; rs6055359; rs6055360; rs6055404; rs6055405; rs6055406; rs6055408; rs6055409; rs6077284; rs6077294; rs6086261; rs6086262; rs6086263; rs6086265; rs6086291; rs6108074; rs6108075; rs6117974; rs6118015; rs6118017; rs6118025; rs6133508; rs6133517; rs6140450; rs6140452; rs6140453; rs7343234; rs8120370; rs8120893

# Metabolic_Enzyme_4_General_References:
10978532; 10777549; 11780052

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
6069

# Metabolic_Enzyme_5_Name:
Serine--pyruvate aminotransferase

# Metabolic_Enzyme_5_Synonyms:
SPT; Alanine-- glyoxylate aminotransferase; AGT

# Metabolic_Enzyme_5_Gene_Name:
AGXT

# Metabolic_Enzyme_5_Protein_Sequence:
>Serinepyruvate aminotransferase
MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEI
KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG
ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLL
LVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF
YLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHG
RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLR
IGLLGCNATRENVDRVTEALRAALQHCPKKKL

# Metabolic_Enzyme_5_Number_of_Residues:
392

# Metabolic_Enzyme_5_Molecular_Weight:
43011

# Metabolic_Enzyme_5_Theoretical_pI:
8.55

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
L-serine + pyruvate = 3-hydroxypyruvate + L- alanine

# Metabolic_Enzyme_5_Pathway:
map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_5_Reaction:
L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00266:Aminotran_5

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.6.1.51;EC 2.6.1.44

# Metabolic_Enzyme_5_GenBank_ID_Protein:
36582

# Metabolic_Enzyme_5_SwissProt_ID:
SPYA_HUMAN (P21549)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
AGXT

# Metabolic_Enzyme_5_Geneatlas_id:
AGXT

# Metabolic_Enzyme_5_hgnc_id:
HGNC:341

# Metabolic_Enzyme_5_PDB_ID:
1H0C

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Peroxisome. Note=Except in some PH1 patients where AGT is found in the mitochondrial matrix

# Metabolic_Enzyme_5_Gene_Sequence:
>1179 bp
ATGGCCTCTCACAAGCTGCTGGTGACCCCCCCCAAGGCCCTGCTCAAGCCCCTCTCCATC
CCCAACCAGCTCCTGCTGGGGCCTGGTCCTTCCAACCTGCCTCCTCGCATCATGGCAGCC
GGGGGGCTGCAGATGATCGGGTCCATGAGCAAGGATATGTACCAGATCATGGACGAGATC
AAGGAAGGCATCCAGTACGTGTTCCAGACCAGGAACCCACTCACACTGGTCATCTCTGGC
TCGGGACACTGTGCCCTGGAGGCCGCCCTGGTCAATGTGCTGGAGCCTGGGGACTCCTTC
CTGGTTGGGGCCAATGGCATTTGGGGGCAGCGAGCCGTGGACATCGGGGAGCGCATAGGA
GCCCGAGTGCACCCGATGACCAAGGACCCTGGAGGCCACTACACACTGCAGGAGGTGGAG
GAGGGCCTGGCCCAGCACAAGCCAGTGCTGCTGTTCTTAACCCACGGGGAGTCGTCCACC
GGCGTGCTGCAGCCCCTTGATGGCTTCGGGGAACTCTGCCACAGGTACAAGTGCCTGCTC
CTGGTGGATTCGGTGGCATCCCTGGGCGGGACCCCCCTTTACATGGACCGGCAAGGCATC
GACATCCTGTACTCGGGCTCCCAGAAGGCCCTGAACGCCCCTCCAGGGACCTCGCTCATC
TCCTTCAGTGACAAGGCCAAAAAGAAGATGTACTCCCGCAAGACGAAGCCCTTCTCCTTC
TACCTGGACATCAAGTGGCTGGCCAACTTCTGGGGCTGTGACGACCAGCCCAGGATGTAC
CATCACACAATCCCCGTCATCAGCCTGTACAGCCTGAGAGAGAGCCTGGCCCTCATTGCG
GAACAGGGCCTGGAGAACAGCTGGCGCCAGCACCGCGAGGCCGCGGCGTATCTGCATGGG
CGCCTGCAGGCACTGGGGCTGCAGCTCTTCGTGAAGGACCCGGCGCTCCGGCTTCCCACA
GTCACCACTGTGGCTGTACCCGCTGGCTATGACTGGAGAGACATCGTCAGCTACGTCATA
GACCACTTCGACATTGAGATCATGGGTGGCCTTGGGCCCTCCACGGGGAAGGTGCTGCGG
ATCGGCCTGCTGGGCTGCAATGCCACCCGCGAGAATGTGGACCGCGTGACGGAGGCCCTG
AGGGCGGCCCTGCAGCACTGCCCCAAGAAGAAGCTGTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X56092

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_5_Locus:
2q36-q37

# Metabolic_Enzyme_5_SNPs:
rs4426527; rs13408961; rs34885252; rs34116584; rs33958047; rs4273214; rs4344931; rs4073369; rs4073370; rs12695032; rs6732985; rs4073597; rs10199038; rs11681134; rs11894759; rs12478859; rs10933640; rs4355101; rs13430507; rs13423821; rs5021686; rs5013752; rs11901056; rs11687303; rs10933641; rs13030904; rs11693280; rs11685698; rs11886288; rs4675876; rs4675875; rs4234095; rs10182575; rs34664134; rs35977912; rs35698882; rs3196760; rs4991357; rs11682457; rs11688815; rs11691745; rs35882315; rs12997245; rs4991356; rs33996129; rs6722479; rs4991354; rs4414673; rs5839789; rs35937797; rs12464426; rs4991360; rs34134404; rs35561942; rs4991355; rs5839787; rs34995778; rs34572785; rs10196315; rs13020254; rs11691886; rs35566646; rs5839788; rs4257395; rs4991359; rs5013751; rs4328626; rs4991361; rs35172778; rs5839786; rs4991358; rs5021687; rs4675793; rs12622523; rs34927888; rs12998301; rs11897804; rs7568864; rs4675877; rs6718131; rs35931917; rs35082207; rs12619921; rs6717643; rs10177846; rs10178744; rs10185214; rs10933510; rs1138103; rs11680732; rs11681382; rs11686679; rs11689640; rs11886874; rs11899555; rs12616061; rs12991730; rs12994627; rs13000529; rs13001584; rs13007644; rs13025495; rs13030611; rs13385816; rs13387029; rs13397515; rs13410652; rs33998315; rs34927891; rs36014033; rs4129624; rs4295000; rs4311055; rs4312490; rs4465762; rs4538195; rs4675792; rs4675869; rs4675871; rs4675872; rs4675874; rs6437372; rs6707763; rs6708304; rs6741220; rs6744422; rs7340215; rs7340501; rs7355583; rs7557279; rs7590032; rs7598309; rs7600847; rs7601670; rs7604393; rs7606856; rs9288742

# Metabolic_Enzyme_5_General_References:
2253628; 1703535; 2363689; 2045108; 2039493; 1349575; 1301173; 8101040; 8507692; 9192270; 10394939; 10862087

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
6068

# Metabolic_Enzyme_6_Name:
Hydroxyacid oxidase 2

# Metabolic_Enzyme_6_Synonyms:
HAOX2; (S-2-hydroxy-acid oxidase, peroxisomal; Long chain alpha-hydroxy acid oxidase; Long- chain L-2-hydroxy acid oxidase

# Metabolic_Enzyme_6_Gene_Name:
HAO2

# Metabolic_Enzyme_6_Protein_Sequence:
>Hydroxyacid oxidase 2
MSLVCLTDFQAHAREQLSKSTRDFIEGGADDSITRDDNIAAFKRIRLRPRYLRDVSEVDT
RTTIQGEEISAPICIAPTGFHCLVWPDGEMSTARAAQAAGICYITSTFASCSLEDIVIAA
PEGLRWFQLYVHPDLQLNKQLIQRVESLGFKALVITLDTPVCGNRRHDIRNQLRRNLTLT
DLQSPKKGNAIPYFQMTPISTSLCWNDLSWFQSITRLPIILKGILTKEDAELAVKHNVQG
IIVSNHGGRQLDEVLASIDALTEVVAAVKGKIEVYLDGGVRTGNDVLKALALGAKCIFLG
RPILWGLACKGEHGVKEVLNILTNEFHTSMALTGCRSVAEINRNLVQFSRL

# Metabolic_Enzyme_6_Number_of_Residues:
351

# Metabolic_Enzyme_6_Molecular_Weight:
38839

# Metabolic_Enzyme_6_Theoretical_pI:
7.69

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_6_Specific_Function:
Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids

# Metabolic_Enzyme_6_Pathway:
map00630  Glyoxylate and dicarboxylate metabolism

# Metabolic_Enzyme_6_Reaction:
(S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF01070:FMN_dh

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.1.3.15

# Metabolic_Enzyme_6_GenBank_ID_Protein:
7208438

# Metabolic_Enzyme_6_SwissProt_ID:
HAOX2_HUMAN (Q9NYQ3)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
HAO2

# Metabolic_Enzyme_6_Geneatlas_id:
HAO2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:4810

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_6_Gene_Sequence:
>1056 bp
ATGTCCTTGGTGTGTTTGACAGACTTTCAGGCCCATGCGCGAGAGCAGCTGTCTAAGTCA
ACTCGGGATTTTATTGAAGGTGGAGCAGATGACAGCATCACGCGGGATGACAACATTGCA
GCATTTAAAAGAATTCGCCTCCGTCCGCGGTACCTGAGAGATGTGTCTGAGGTGGACACC
AGAACCACAATCCAAGGGGAGGAGATCAGTGCCCCTATTTGTATCGCACCCACAGGGTTC
CACTGCCTTGTCTGGCCTGATGGGGAAATGAGCACAGCAAGAGCTGCCCAAGCGGCTGGT
ATCTGCTACATCACCAGCACATTTGCCAGCTGTAGCCTTGAAGACATTGTCATTGCAGCT
CCCGAAGGCCTCCGATGGTTCCAACTCTATGTGCATCCAGACCTGCAGCTGAACAAACAG
TTGATCCAGAGGGTAGAATCCCTAGGTTTCAAAGCTTTGGTAATAACTTTGGATACACCT
GTATGTGGCAACAGGCGACATGACATTCGAAACCAGTTGAGGAGGAACTTAACACTAACA
GATCTTCAATCACCTAAAAAGGGAAATGCAATACCTTATTTCCAGATGACTCCTATCAGC
ACTTCTCTCTGCTGGAATGATCTCTCCTGGTTTCAGAGCATAACTCGATTGCCCATCATC
CTGAAAGGGATTTTGACAAAAGAGGATGCAGAGTTAGCTGTGAAGCACAATGTCCAGGGT
ATCATTGTTTCCAACCATGGTGGGAGGCAGCTTGATGAGGTTCTTGCTTCAATTGATGCT
TTGACAGAAGTGGTGGCTGCTGTAAAGGGGAAAATTGAAGTCTACCTGGATGGCGGGGTC
CGAACTGGCAATGATGTGCTGAAGGCTCTGGCCCTTGGAGCTAAGTGCATTTTTCTTGGG
AGACCAATCCTATGGGGCCTTGCCTGCAAGGGTGAACATGGTGTTAAGGAAGTTTTGAAC
ATTTTAACAAATGAGTTCCACACTTCCATGGCCCTTACAGGCTGCCGGTCGGTCGCTGAG
ATCAATCGAAACTTGGTCCAGTTTTCCAGGCTGTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AF231917

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_6_Locus:
1p13.3-p13.1

# Metabolic_Enzyme_6_SNPs:
rs34638261; rs2275607; rs35295280; rs2224995; rs3765953; rs3765955; rs3765951; rs3765956; rs10923804; rs7514283; rs6667104; rs3765952; rs10494225; rs6694847; rs6667203; rs10923802; rs6691943; rs7513419; rs12071883; rs6704362; rs7529983; rs3753260; rs4659003; rs3765954; rs3765957; rs10802090; rs17023507; rs17013697; rs1341007; rs2298028; rs6670497; rs6667679; rs2275608; rs1417604; rs7552690; rs2298027; rs12032036; rs6663287; rs3765949; rs3207643; rs6428816; rs10923805; rs7528838; rs2182243; rs17023517; rs3765950; rs11586988; rs9728422; rs10802092; rs6675731; rs3753263; rs3753264; rs3753262; rs6656360; rs3753261; rs12402209; rs6661625; rs41313995; rs41306185; rs4659002; rs11398278; rs12753975; rs12118920; rs12743964; rs34875589; rs12724529; rs7547008; rs36096589; rs35468112; rs35672626; rs35324941; rs35351478; rs12404377; rs35476629; rs3753259; rs4659004; rs11582039; rs10585699; rs11366732; rs41313280; rs6678290; rs34306563; rs28570107; rs41443445; rs3753265; rs3834006; rs3818927; rs3820031; rs10923808; rs12047811; rs12404344; rs12740687; rs1325751; rs1536228; rs17023479; rs1935248; rs2005390; rs2885607; rs35298838; rs3753266; rs3820032; rs6658331; rs6683756; rs879333; rs879334; rs942903; rs947127

# Metabolic_Enzyme_6_General_References:
10777549

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
6817

# Metabolic_Enzyme_7_Name:
Insulin receptor precursor

# Metabolic_Enzyme_7_Synonyms:
IR; CD220 antigen[Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta]

# Metabolic_Enzyme_7_Gene_Name:
INSR

# Metabolic_Enzyme_7_Protein_Sequence:
>Insulin receptor precursor
MGTGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHL
QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL
VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE
ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL
GNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQG
CHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC
TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL
EIGNYSFYALDNQNLRQLWDWSKHNLTTTQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE
RNDIALKTNGDKASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQ
NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS
DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE
RQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQIL
KELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAF
PNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYV
SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCV
SRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIG
PLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSR
EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKG
FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA
AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV
RWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDN
CPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEME
FEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSN
PS

# Metabolic_Enzyme_7_Number_of_Residues:
1382

# Metabolic_Enzyme_7_Molecular_Weight:
156308

# Metabolic_Enzyme_7_Theoretical_pI:
6.18

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  epidermal growth factor receptor activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein-tyrosine kinase activity
Function:  transmembrane receptor protein tyrosine kinase activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  enzyme linked receptor protein signaling pathway
Process:  transmembrane receptor protein tyrosine kinase signaling pathway
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
Not Available

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00041:fn3;
PF00757:Furin-like;
PF07714:Pkinase_Tyr;
PF01030:Recep_L_domain

# Metabolic_Enzyme_7_Signals:
1-27

# Metabolic_Enzyme_7_Transmembrane_Regions:
957-979

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.7.10.1

# Metabolic_Enzyme_7_GenBank_ID_Protein:
307070

# Metabolic_Enzyme_7_SwissProt_ID:
INSR_HUMAN (P06213)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
INSR

# Metabolic_Enzyme_7_Geneatlas_id:
INSR

# Metabolic_Enzyme_7_hgnc_id:
HGNC:6091

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Metabolic_Enzyme_7_Gene_Sequence:
>4149 bp
ATGGGCACCGGGGGCCGGCGGGGGGCGGCGGCCGCGCCGCTGCTGGTGGCGGTGGCCGCG
CTGCTACTGGGCGCCGCGGGCCACCTGTACCCCGGAGAGGTGTGTCCCGGCATGGATATC
CGGAACAACCTCACTAGGTTGCATGAGCTGGAGAATTGCTCTGTCATCGAAGGACACTTG
CAGATACTCTTGATGTTCAAAACGAGGCCCGAAGATTTCCGAGACCTCAGTTTCCCCAAA
CTCATCATGATCACTGATTACTTGCTGCTCTTCCGGGTCTATGGGCTCGAGAGCCTGAAG
GACCTGTTCCCCAACCTCACGGTCATCCGGGGATCACGACTGTTCTTTAACTACGCGCTG
GTCATCTTCGAGATGGTTCACCTCAAGGAACTCGGCCTCTACAACCTGATGAACATCACC
CGGGGTTCTGTCCGCATCGAGAAGAACAATGAGCTCTGTTACTTGGCCACTATCGACTGG
TCCCGTATCCTGGATTCCGTGGAGGATAATCACATCGTGTTGAACAAAGATGACAACGAG
GAGTGTGGAGACATCTGTCCGGGTACCGCGAAGGGCAAGACCAACTGCCCCGCCACCGTC
ATCAACGGGCAGTTTGTCGAACGATGTTGGACTCATAGTCACTGCCAGAAAGTTTGCCCG
ACCATCTGTAAGTCACACGGCTGCACCGCCGAAGGCCTCTGTTGCCACAGCGAGTGCCTG
GGCAACTGTTCTCAGCCCGACGACCCCACCAAGTGCGTGGCCTGCCGCAACTTCTACCTG
GACGGCAGGTGTGTGGAGACCTGCCCGCCCCCGTACTACCACTTCCAGGACTGGCGCTGT
GTGAACTTCAGCTTCTGCCAGGACCTGCACCACAAATGCAAGAACTCGCGGAGGCAGGGC
TGCCACCAATACGTCATTCACAACAACAAGTGCATCCCTGAGTGTCCCTCCGGGTACACG
ATGAATTCCAGCAACTTGCTGTGCACCCCATGCCTGGGTCCCTGTCCCAAGGTGTGCCAC
CTCCTAGAAGGCGAGAAGACCATCGACTCGGTGACGTCTGCCCAGGAGCTCCGAGGATGC
ACCGTCATCAACGGGAGTCTGATCATCAACATTCGAGGAGGCAACAATCTGGCAGCTGAG
CTAGAAGCCAACCTCGGCCTCATTGAAGAAATTTCAGGGTATCTAAAAATCCGCCGATCC
TACGCTCTGGTGTCACTTTCCTTCTTCCGGAAGTTACGTCTGATTCGAGGAGAGACCTTG
GAAATTGGGAACTACTCCTTCTATGCCTTGGACAACCAGAACCTAAGGCAGCTCTGGGAC
TGGAGCAAACACAACCTCACCACCACTCAGGGGAAACTCTTCTTCCACTATAACCCCAAA
CTCTGCTTGTCAGAAATCCACAAGATGGAAGAAGTTTCAGGAACCAAGGGGCGCCAGGAG
AGAAACGACATTGCCCTGAAGACCAATGGGGACAAGGCATCCTGTGAAAATGAGTTACTT
AAATTTTCTTACATTCGGACATCTTTTGACAAGATCTTGCTGAGATGGGAGCCGTACTGG
CCCCCCGACTTCCGAGACCTCTTGGGGTTCATGCTGTTCTACAAAGAGGCCCCTTATCAG
AATGTGACGGAGTTCGATGGGCAGGATGCGTGTGGTTCCAACAGTTGGACGGTGGTAGAC
ATTGACCCACCCCTGAGGTCCAACGACCCCAAATCACAGAACCACCCAGGGTGGCTGATG
CGGGGTCTCAAGCCCTGGACCCAGTATGCCATCTTTGTGAAGACCCTGGTCACCTTTTCG
GATGAACGCCGGACCTATGGGGCCAAGAGTGACATCATTTATGTCCAGACAGATGCCACC
AACCCCTCTGTGCCCCTGGATCCAATCTCAGTGTCTAACTCATCATCCCAGATTATTCTG
AAGTGGAAACCACCCTCCGACCCCAATGGCAACATCACCCACTACCTGGTTTTCTGGGAG
AGGCAGGCGGAAGACAGTGAGCTGTTCGAGCTGGATTATTGCCTCAAAGGGCTGAAGCTG
CCCTCGAGGACCTGGTCTCCACCATTCGAGTCTGAAGATTCTCAGAAGCACAACCAGAGT
GAGTATGAGGATTCGGCCGGCGAATGCTGCTCCTGTCCAAAGACAGACTCTCAGATCCTG
AAGGAGCTGGAGGAGTCCTCGTTTAGGAAGACGTTTGAGGATTACCTGCACAACGTGGTT
TTCGTCCCCAGAAAAACCTCTTCAGGCACTGGTGCCGAGGACCCTAGGCCATCTCGGAAA
CGCAGGTCCCTTGGCGATGTTGGGAATGTGACGGTGGCCGTGCCCACGGTGGCAGCTTTC
CCCAACACTTCCTCGACCAGCGTGCCCACGAGTCCGGAGGAGCACAGGCCTTTTGAGAAG
GTGGTGAACAAGGAGTCGCTGGTCATCTCCGGCTTGCGACACTTCACGGGCTATCGCATC
GAGCTGCAGGCTTGCAACCAGGACACCCCTGAGGAACGGTGCAGTGTGGCAGCCTACGTC
AGTGCGAGGACCATGCCTGAAGCCAAGGCTGATGACATTGTTGGCCCTGTGACGCATGAA
ATCTTTGAGAACAACGTCGTCCACTTGATGTGGCAGGAGCCGAAGGAGCCCAATGGTCTG
ATCGTGCTGTATGAAGTGAGTTATCGGCGATATGGTGATGAGGAGCTGCATCTCTGCGTC
TCCCGCAAGCACTTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCTGTCACCGGGGAAC
TACAGCGTGCGAATCCGGGCCACCTCCCTTGCGGGCAACGGCTCTTGGACGGAACCCACC
TATTTCTACGTGACAGACTATTTAGACGTCCCGTCAAATATTGCAAAAATTATCATCGGC
CCCCTCATCTTTGTCTTTCTCTTCAGTGTTGTGATTGGAAGTATTTATCTATTCCTGAGA
AAGAGGCAGCCAGATGGGCCGCTGGGACCGCTTTACGCTTCTTCAAACCCTGAGTATCTC
AGTGCCAGTGATGTGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTCGA
GAGAAGATCACCCTCCTTCGAGAGCTGGGGCAGGGCTCCTTCGGCATGGTGTATGAGGGC
AATGCCAGGGACATCATCAAGGGTGAGGCAGAGACCCGCGTGGCGGTGAAGACGGTCAAC
GAGTCAGCCAGTCTCCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGGGC
TTCACCTGCCATCACGTGGTGCGCCTCCTGGGAGTGGTGTCCAAGGGCCAGCCCACGCTG
GTGGTGATGGAGCTGATGGCTCACGGAGACCTGAAGAGCTACCTCCGTTCTCTGCGGCCA
GAGGCTGAGAATAATCCTGGCCGCCCTCCCCCTACCCTTCAAGAGATGATTCAGATGGCG
GCAGAGATTGCTGACGGGATGGCCTACCTGAACGCCAAGAAGTTTGTGCATCGGGACCTG
GCAGCGAGAAACTGCATGGTCGCCCATGATTTTACTGTCAAAATTGGAGACTTTGGAATG
ACCAGAGACATCTATGAAACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTCCCTGTA
CGGTGGATGGCACCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTCTTCTGACATGTGG
TCCTTTGGCGTGGTCCTTTGGGAAATCACCAGCTTGGCAGAACAGCCTTACCAAGGCCTG
TCTAATGAACAGGTGTTGAAATTTGTCATGGATGGAGGGTATCTGGATCAACCCGACAAC
TGTCCAGAGAGAGTCACTGACCTCATGCGCATGTGCTGGCAATTCAACCCCAAGATGAGG
CCAACCTTCCTGGAGATTGTCAACCTGCTCAAGGACGACCTGCACCCCAGCTTTCCAGAG
GTGTCGTTCTTCCACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGGAG
TTTGAGGACATGGAGAATGTGCCCCTGGACCGTTCCTCGCACTGTCAGAGGGAGGAGGCG
GGGGGCCGGGATGGAGGGTCCTCGCTGGGTTTCAAGCGGAGCTACGAGGAACACATCCCT
TACACACACATGAACGGAGGCAAGAAAAACGGGCGGATTCTGACCTTGCCTCGGTCCAAT
CCTTCCTAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
M10051

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_7_Locus:
19p13.3-p13.2

# Metabolic_Enzyme_7_SNPs:
rs7508518; rs891087; rs2059806; rs2229434; rs2229431; rs2245655; rs16994192; rs2229430; rs1799817; rs2229428; rs9282756; rs16994157; rs2962; rs36081066; rs2963; rs16994210; rs6413501; rs9282757; rs1799815; rs1051690; rs41416247; rs1035939; rs2059807; rs919275; rs4804103; rs8110377; rs3815901; rs8109308; rs10414819; rs2245649; rs4804404; rs2860175; rs7252268; rs4804416; rs8103955; rs1035941; rs2860178; rs7254487; rs10408844; rs8110428; rs6510960; rs6510950; rs6510959; rs890830; rs10415205; rs10416429; rs890860; rs1366234; rs8110116; rs4247374; rs11880482; rs3786681; rs8111710; rs6510976; rs2860177; rs10417205; rs7256657; rs8104314; rs8100109; rs2860173; rs7254060; rs10424224; rs7255710; rs7258382; rs7245562; rs2042901; rs1896639; rs7248104; rs7508679; rs12610022; rs8107575; rs890862; rs3848573; rs4804409; rs2081880; rs4804428; rs1346490; rs8108622; rs10221462; rs6417197; rs890861; rs8106042; rs2860172; rs10401485; rs2860183; rs11668751; rs4804366; rs8107928; rs4804414; rs2115386; rs8107359; rs4804304; rs8103483; rs7251963; rs10500204; rs2042902; rs3852876; rs10427021; rs10420382; rs7255382; rs6510953; rs10405423; rs2245143; rs16994298; rs6510969; rs8103497; rs11883202; rs6510974; rs1366235; rs17253937; rs12461909; rs10402346; rs10423156; rs10424085; rs6510958; rs16994200; rs8109559; rs11672443; rs10411728; rs8102764; rs890859; rs2396186; rs12979424; rs12971499; rs17254521; rs7248939; rs11878933; rs8106714; rs4608435; rs6510970; rs10422199; rs11669671; rs8102668; rs7256730; rs11672032; rs10413734; rs6510957; rs35169098; rs6510956; rs2042903; rs6510973; rs8112883; rs2894551; rs10411667; rs8113777; rs11672739; rs4804425; rs7258944; rs6510977; rs3745544; rs3859489; rs10419421; rs8110533; rs16994167; rs6413502; rs11670960; rs4804069; rs2042904; rs4804444; rs10420901; rs7247736; rs8106080; rs891088; rs1549616; rs10221473; rs7247119; rs3745548; rs2288404; rs4804377; rs3745545; rs10404166; rs8109384; rs4482400; rs4804443; rs6510955; rs11669336; rs10412485; rs11670892; rs11666226; rs10408374; rs2396188; rs6510962; rs890829; rs8109285; rs8100311; rs11883325; rs2252673; rs10426094; rs28540607; rs11882992; rs2894552; rs7255731; rs4804395; rs8103744; rs10415589; rs10420008; rs13306446; rs7254358; rs11671975; rs4804372; rs4804072; rs8111012; rs41315074; rs6510954; rs3745546; rs3848575; rs10403033; rs7256994; rs6510975; rs3815902; rs4804415; rs10421414; rs8109957; rs16994221; rs8109687; rs8100553; rs3890483; rs7257990; rs6510961; rs2352953; rs3848574; rs2860184; rs4499341; rs3848572; rs10411676; rs8112793; rs4804411; rs7507979; rs10404318; rs6510951; rs16994185; rs12461206; rs2860179; rs2396185; rs7254921; rs8106329; rs10403257; rs10410272; rs12985940; rs7256474; rs10416539; rs1808538; rs3786680; rs4325676; rs2303672; rs10422585; rs8113542; rs7256990; rs16994189; rs3786682; rs13306458; rs881759; rs11085217; rs7258229; rs4804112; rs12609789; rs35771267; rs12611104; rs4804222; rs8113351; rs4804071; rs7252150; rs10416131; rs12608575; rs13306455; rs8104283; rs8100653; rs12460089; rs12610413; rs9676400; rs10402062; rs10426979; rs10424782; rs8105787; rs4372802; rs12710100; rs11672896; rs8103366; rs4804455; rs34520134; rs11666196; rs7246346; rs7260417; rs35639485; rs2081882; rs13306451; rs16990074; rs8109590; rs4804433; rs4804405; rs4804403; rs9789298; rs16994213; rs2245648; rs11668772; rs12611355; rs4804424; rs10421872; rs3745547; rs11881212; rs1808539; rs12610983; rs11085221; rs11668724; rs2017199; rs12608774; rs34030944; rs11670932; rs12462446; rs12608528; rs16994171; rs35616329; rs11085212; rs12608977; rs6510949; rs16994316; rs2860174; rs11671045; rs8105852; rs11670971; rs10419596; rs11085218; rs41339753; rs16994352; rs8109131; rs11671338; rs11671460; rs16994216; rs10403619; rs35950506; rs10403229; rs1366246; rs12971756; rs4804420; rs8100807; rs8106700; rs10403764; rs34680902; rs10408111; rs6510978; rs7260634; rs12608565; rs2396187; rs8108933; rs1975030; rs8108661; rs12608547; rs36205677; rs11085213; rs12971331; rs5826963; rs11672597; rs4804195; rs2081881; rs10407499; rs11671419; rs12459713; rs11671458; rs34637545; rs8106126; rs8106735; rs7252534; rs10412476; rs7249200; rs10423028; rs3929068; rs11085219; rs8105232; rs12460478; rs11881057; rs8100562; rs4550582; rs10416766; rs16990079; rs4804373; rs10402777; rs7257359; rs12982656; rs41509747; rs17254556; rs10420869; rs12974699; rs16994220; rs35931207; rs11667110; rs10417000; rs11673363; rs8109040; rs11665904; rs12463278; rs10419413; rs8100252; rs11878560; rs11669384; rs10419104; rs4804368; rs10413173; rs7252074; rs4804422; rs10418811; rs10406869; rs1975031; rs6510979; rs4804457; rs16994164; rs10414388; rs10408733; rs7252192; rs12460805; rs11883285; rs4804092; rs12460809; rs10427109; rs10418684; rs1035940; rs8103883; rs10409259; rs10401628; rs7257345; rs12460755; rs10418842; rs10426819; rs8112748; rs1800658; rs35115418; rs6510952; rs4804418; rs11085220; rs4031066; rs11881167; rs17175860; rs1035942; rs36038439; rs1811344; rs16994173; rs8100501; rs8104049; rs3859490; rs8107417; rs16994314; rs34060473; rs17175790; rs12459488; rs11673642; rs10425868; rs12609995; rs12609034; rs8105406; rs12609574; rs7507622; rs10408759; rs7508692; rs8106071; rs12610987; rs10425129; rs4470256; rs10853999; rs16994169; rs11668986; rs10406487; rs12610686; rs10407075; rs10221475; rs4804070; rs11670972; rs6510947; rs10425864; rs10404551; rs1529448; rs10403019; rs35319747; rs2081879; rs8101843; rs34970365; rs11671381; rs8102612; rs4804421; rs8101064; rs12608473; rs34380568; rs4804219; rs3786683; rs12608462; rs11671314; rs7257866; rs12973279; rs11671297; rs12459862; rs10404874; rs3745550; rs1051651; rs12462548; rs2860189; rs1864009; rs12981042; rs1051692; rs1051691; rs1799816; rs13306449; rs2162771; rs35045353; rs41352749; rs2860188; rs9676819; rs17846409; rs41304772; rs1541806; rs41362249; rs41507444; rs2860171; rs4804293; rs1051689; rs35434645; rs4427922; rs12985490; rs8105224; rs10559506; rs34799768; rs11323545; rs12973110; rs2115070; rs33943571; rs12973230; rs7508459; rs8111943; rs3997563; rs28461923; rs8102363; rs28378198; rs11879297; rs3084141; rs12971601; rs11672694; rs35211876; rs13344151; rs35216879; rs10706876; rs12980108; rs34590794; rs11670905; rs11453584; rs28614180; rs35755805; rs12151134; rs11409928; rs10413831; rs28817398; rs12971459; rs3957263; rs11334308; rs7246290; rs5826960; rs11085222; rs34520561; rs35961932; rs12610776; rs10424426; rs7245524; rs11085216; rs34535970; rs11882912; rs35608213; rs7250292; rs12977065; rs8107074; rs8108574; rs35883676; rs10426943; rs11334237; rs12983945; rs12982692; rs934099; rs10419238; rs13306445; rs36145952; rs35433137; rs7250206; rs10404027; rs35973493; rs4804426; rs11666383; rs34194998; rs13306447; rs41300628; rs8100770; rs10410204; rs8101697; rs34478636; rs10706877; rs35743970; rs12975973; rs35679001; rs35476514; rs12971764; rs12985449; rs11342133; rs4804748; rs12971644; rs7257462; rs7253146; rs28506489; rs11402614; rs34840745; rs7249266; rs8105456; rs34807336; rs8101107; rs35341203; rs34501799; rs10549803; rs4804412; rs10672867; rs11393505; rs8102015; rs34457204; rs11314337; rs28532146; rs3943875; rs28608523; rs11404027; rs35959455; rs11667858; rs12463005; rs11673387; rs10423620; rs34589482; rs10603890; rs7508686; rs3837941; rs28532199; rs12609445; rs28456272; rs35058666; rs10409516; rs4584943; rs34215387; rs34444204; rs12973862; rs34335480; rs35884239; rs4804094; rs34105625; rs12985804; rs11424106; rs35482402; rs28538777; rs36043050; rs10414441; rs34734821; rs10716335; rs4804099; rs12978317; rs35928600; rs11345033; rs8102016; rs11670022; rs7245757; rs7254769; rs10567171; rs35908077; rs28706345; rs4031067; rs5826964; rs10630962; rs12608943; rs35625633; rs34198681; rs5025471; rs12463007; rs34734343; rs12978385; rs12972004; rs36092805; rs12974176; rs28376271; rs35231807; rs35672896; rs7256547; rs11882025; rs1529449; rs35025189; rs7260633; rs35296670; rs12973977; rs10415863; rs34316793; rs35734414; rs7250205; rs28786231; rs34090901; rs12973088; rs7245909; rs2352955; rs2010975; rs11274310; rs10418462; rs13306448; rs7257324; rs10710758; rs4804374; rs11085224; rs34757652; rs10571827; rs12978583; rs8107657; rs35886121; rs10659627; rs6510968; rs36021333; rs34095124; rs34316931; rs34338074; rs35763064; rs10421925; rs34622759; rs3835070; rs10418533; rs12985988; rs28687870; rs4804413; rs8103934; rs35329618; rs10655240; rs34688709; rs10415781; rs28628556; rs28663279; rs12975950; rs41315976; rs35783032; rs28377228; rs13344920; rs41398545; rs34391898; rs10417142; rs12979425; rs7257973; rs35822114; rs2059880; rs11402615; rs10412651; rs28665207; rs8102954; rs7245777; rs10411100; rs35890851; rs12977461; rs7257748; rs8102376; rs28651686; rs35259595; rs34343766; rs36073087; rs1469401; rs34328549; rs8100585; rs4804093; rs12462797; rs11330701; rs11382469; rs11541826; rs8103792; rs8103869; rs12973012; rs35649656; rs12986062; rs12608967; rs10628081; rs35366818; rs5826959; rs8105997; rs1808531; rs12978694; rs35776370; rs1017319; rs12986363; rs8100068; rs10607146; rs6417196; rs8104305; rs34013042; rs34745042; rs10408312; rs28701643; rs2288406; rs34340997; rs11356917; rs10403048; rs41336349; rs35656751; rs7250937; rs2352954; rs12976607; rs12979471; rs11399934; rs34319011; rs8102052; rs10404468; rs12971642; rs34318821; rs10532581; rs11368512; rs11666330; rs12971628; rs35055219; rs35762925; rs8113253; rs28532116; rs10610640; rs12610860; rs36064128; rs41505247; rs35043869; rs10411191; rs34073323; rs8110518; rs11363694; rs35321264; rs34932589; rs10614014; rs11360988; rs35283731; rs11882212; rs28453946; rs13306461; rs9676900; rs35079632; rs11449687; rs11387493; rs35692691; rs10653967; rs4273151; rs11400403; rs36098859; rs35571068; rs28705950; rs10411868; rs12151327; rs12973864; rs33988618; rs35195999; rs10547236; rs34967188; rs28711941; rs10626946; rs34109787; rs10571826; rs34160865; rs35277855; rs12980847; rs2288405; rs10533917; rs4804100; rs9676417; rs7507985; rs34380919; rs11292032; rs34526397; rs4328554; rs8103092; rs10419597; rs3997561; rs11359732; rs34225879; rs11085214; rs4031077; rs10415017; rs10424428; rs4804419; rs4804113; rs35964473; rs12973990; rs28843071; rs28482263; rs10714669; rs35310037; rs34938351; rs35417951; rs35831943; rs7409488; rs10410260; rs12973878; rs11881672; rs34670852; rs34202975; rs34022528; rs4804295; rs12982634; rs34720676; rs10416358; rs34805383; rs4804101; rs13306459; rs10628444; rs34757847; rs10415649; rs35639305; rs12973853; rs4804376; rs11312313; rs12976730; rs28406461; rs4371268; rs36106108; rs35017727; rs34778099; rs8105223; rs10424900; rs12982677; rs4804090; rs10415107; rs34719250; rs12610004; rs4273153; rs28497247; rs11395249; rs11368513; rs2303673; rs28451164; rs34182944; rs12611307; rs4538117; rs35444478; rs3084138; rs2162940; rs12981659; rs12986364; rs11299975; rs36047283; rs768129; rs28576486; rs28695870; rs4804427; rs12609950; rs11085215; rs28675285; rs35761321; rs8105391; rs10404406; rs10420973; rs36035559; rs4630674; rs12971960; rs35175375; rs10593632; rs34269817; rs34242449; rs12983149; rs12976239; rs11335901; rs34064539; rs7252542; rs5826961; rs41412545; rs13306460; rs34273927; rs12977534; rs3037834; rs10404831; rs10421955; rs12978472; rs34339934; rs8113290; rs41306363; rs12973087; rs10416407; rs7257861; rs11343255; rs34846316; rs11673358; rs34453877; rs11879819; rs7257663; rs28706247; rs10422180; rs28671367; rs11269686; rs28763275; rs12984529; rs4804410; rs34905540; rs10659628; rs34080394; rs10671298; rs12982412; rs36047075; rs2894553; rs28633204; rs34057185; rs11415975; rs2396184; rs35247711; rs11387492; rs3837940; rs35158638; rs10410130; rs4804073; rs34667861; rs7255781; rs12979722; rs11409677; rs10416958; rs28550121; rs11880756; rs10581605; rs5826965; rs41307635; rs10415870; rs34045095; rs10415919; rs41315072; rs1049945; rs12463045; rs1864010; rs10422223; rs10416100; rs3833238; rs10415445; rs11554036; rs2860190; rs12132; rs34463285; rs11343125; rs3209638; rs35828695; rs10698409; rs10414835; rs1052371; rs12150997; rs12642; rs1366600; rs1366601; rs1864193; rs2967661; rs34883124; rs3745551; rs7507911; rs890831

# Metabolic_Enzyme_7_General_References:
2859121; 2983222; 2210055; 3447155; 2211730; 3680248; 2777789; 2806055; 2280779; 2538124; 2369896; 2566545; 3166375; 2544997; 1472036; 1321605; 2842060; 3101064; 7559478; 11374898; 7997262; 9312016; 3283938; 2834824; 2479553; 2544998; 2168397; 2121734; 2365819; 1963473; 2040394; 2002058; 1890161; 1607067; 1607076; 1563582; 1730625; 1470163; 8432414; 8243830; 8458533; 8390949; 8242067; 8096518; 8388389; 8326490; 8419945; 8288049; 8314008; 8082780; 8188715; 7983039; 7815442; 7657032; 7538143; 8890729; 8636294; 9199575; 9175790; 9299395; 9249867; 9703342; 10443650; 10733238; 11260230; 12107746; 12023989; 12538626

# Metabolic_Enzyme_7_References:
17039177; 17100583; 17119271

# Metabolic_Enzyme_8_ID:
5331

# Metabolic_Enzyme_8_Name:
Alkaline phosphatase, placental-like precursor

# Metabolic_Enzyme_8_Synonyms:
Alkaline phosphatase Nagao isozyme; Germ-cell alkaline phosphatase; GCAP; PLAP-like; ALP-1

# Metabolic_Enzyme_8_Gene_Name:
ALPPL2

# Metabolic_Enzyme_8_Protein_Sequence:
>Alkaline phosphatase, placentallike precursor
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLG
DGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLC
GVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDY
SQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRD
STLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERA
GQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL
KDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHV
MAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP

# Metabolic_Enzyme_8_Number_of_Residues:
532

# Metabolic_Enzyme_8_Molecular_Weight:
57378

# Metabolic_Enzyme_8_Theoretical_pI:
6.31

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
A phosphate monoester + H(2)O = an alcohol + phosphate

# Metabolic_Enzyme_8_Pathway:
map00361  gamma-Hexachlorocyclohexane degradation;
 map00790  Folate biosynthesis

# Metabolic_Enzyme_8_Reaction:
A phosphate monoester + H2O = an alcohol + phosphate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00245:Alk_phosphatase

# Metabolic_Enzyme_8_Signals:
1-19

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.1.3.1

# Metabolic_Enzyme_8_GenBank_ID_Protein:
178428

# Metabolic_Enzyme_8_SwissProt_ID:
PPBN_HUMAN (P10696)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
ALPPL2

# Metabolic_Enzyme_8_Geneatlas_id:
ALPPL2

# Metabolic_Enzyme_8_hgnc_id:
HGNC:441

# Metabolic_Enzyme_8_PDB_ID:
1EW2

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Metabolic_Enzyme_8_Gene_Sequence:
>1599 bp
ATGCAGGGGCCCTGGGTGCTGCTCCTGCTGGGCCTGAGGCTACAGCTCTCCCTGGGCATC
ATCCCAGTTGAGGAGGAGAACCCGGACTTCTGGAACCGCCAGGCAGCCGAGGCCCTGGGT
GCCGCCAAGAAGCTGCAGCCTGCACAGACAGCCGCCAAGAACCTCATCATGTTCCTGGGT
GACGGGATGGGGGTGTCTACGGTGACAGCTGCCAGGATCCTAAAAGGGCAGAAGAAGGAC
AAACTGGGGCCTGAGACCTTCCTGGCCATGGACCGCTTCCCGTACGTGGCTCTGTCCAAG
ACATACAGTGTAGACAAGCATGTGCCAGACAGTGGAGCCACAGCCACGGCCTACCTGTGC
GGGGTCAAGGGCAACTTCCAGACCATTGGCTTGAGTGCAGCCGCCCGCTTTAACCAGTGC
AACACGACACGCGGCAACGAGGTCATCTCCGTGGTGAATCGGGCCAAGAAAGCAGGAAAG
TCAGTGGGAGTGGTAACCACCACACGGGTGCAGCATGCCTCGCCAGCCGGCACCTACGCC
CACACGGTGAACCGCAACTGGTACTCGGATGCCGACGTGCCTGCCTCGGCCCGCCAGGAG
GGGTGCCAGGACATCGCCACGCAGCTCATCTCCAACATGGACATTGATGTGATCCTAGGT
GGAGGCCGAAAGTACATGTTTCCCATGGGGACCCCAGACCCTGAGTACCCAGATGACTAC
AGCCAAGGTGGGACCAGGCTGGACGGGAAGAATCTGGTGCAGGAATGGCTGGCGAAGCAC
CAGGGTGCCCGGTACGTGTGGAACCGCACTGAGCTCCTGCAGGCTTCCCTGGACCCGTCT
GTGACCCATCTCATGGGTCTCTTTGAGCCTGGAGACATGAAATACGAGATCCACCGAGAC
TCCACACTGGACCCCTCCCTGATGGAGATGACAGAGGCTGCCCTGCTCCTGCTGAGCAGG
AACCCCCGCGGCTTCTTCCTCTTCGTGGAGGGTGGTCGCATCGACCATGGTCATCATGAA
AGCAGGGCTTACCGGGCACTGACTGAGACGATCATGTTCGACGACGCCATTGAGAGGGCG
GGCCAGCTCACCAGCGAGGAGGACACGCTGAGCCTCGTCACTGCCGACCACTCCCACGTC
TTCTCCTTCGGAGGCTACCCCCTGCGAGGGAGCTCCATCTTCGGGCTGGCCCCTGGCAAG
GCCCGGGACAGGAAGGCCTACACGGTCCTCCTATACGGAAACGGTCCAGGCTATGTGCTC
AAGGACGGCGCCCGGCCGGATGTTACGGAGAGCGAGAGCGGGAGCCCCGAGTATCGGCAG
CAGTCAGCAGTGCCCCTGGACGGAGAGACCCACGCAGGCGAGGACGTGGCGGTGTTCGCG
CGCGGCCCGCAGGCGCACCTGGTTCACGGCGTGCAGGAGCAGACCTTCATAGCGCACGTC
ATGGCCTTCGCCGCCTGCCTGGAGCCCTACACCGCCTGCGACCTGGCGCCCCCCGCCGGC
ACCACCGACGCCGCGCACCCGGGGCCGTCCGTGGTCCCCGCGTTGCTTCCTCTGCTGGCA
GGGACCTTGCTGCTGCTGGGGACGGCCACTGCTCCCTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
J03252

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_8_Locus:
2q37

# Metabolic_Enzyme_8_SNPs:
rs1048983; rs1048999; rs17416141; rs2090543; rs1048997; rs1009934; rs2678519; rs2697781; rs3828248; rs3828254; rs2697767; rs3828249; rs2697768; rs1048995; rs16836187; rs3116148; rs1130334; rs41265119; rs41265117; rs3111340; rs41265115; rs1049002; rs1049001; rs3189080; rs3924351; rs1049003; rs1130348; rs1130351; rs3924352; rs3189077; rs6728119; rs2091555; rs2945420; rs2678518; rs41265113; rs3111339; rs3833560; rs2678517; rs2945421; rs41265111; rs2091556; rs3830644; rs3828251; rs3828253; rs2697769; rs11363206; rs3828250; rs3828252; rs11678251; rs1001868; rs10195918; rs13002718; rs13003189; rs13412526; rs1878691; rs2082841; rs2082842; rs2139026; rs2139027; rs2573208; rs2573209; rs2697766; rs2697790; rs2697791; rs2697792; rs2697793; rs2741321; rs2853380; rs732581; rs744873; rs744874; rs790050; rs790051

# Metabolic_Enzyme_8_General_References:
2834730; 2745460; 2297757; 2162249; 3387245

# Metabolic_Enzyme_8_References:
17071070

# Metabolic_Enzyme_9_ID:
5447

# Metabolic_Enzyme_9_Name:
Hexokinase-1

# Metabolic_Enzyme_9_Synonyms:
Hexokinase type I; HK I; Brain form hexokinase

# Metabolic_Enzyme_9_Gene_Name:
HK1

# Metabolic_Enzyme_9_Protein_Sequence:
>Hexokinase1
MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT
VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH
GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV
EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME
ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM
YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG
VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH
PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT
KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV
LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF
TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG
TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD
IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG
IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA
VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG
AALITAVGVRLRTEASS

# Metabolic_Enzyme_9_Number_of_Residues:
917

# Metabolic_Enzyme_9_Molecular_Weight:
102487

# Metabolic_Enzyme_9_Theoretical_pI:
6.78

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_9_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism;
 map00521  Streptomycin biosynthesis;
 map00530  Aminosugars metabolism

# Metabolic_Enzyme_9_Reaction:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00349:Hexokinase_1;
PF03727:Hexokinase_2

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.7.1.1

# Metabolic_Enzyme_9_GenBank_ID_Protein:
184021

# Metabolic_Enzyme_9_SwissProt_ID:
HXK1_HUMAN (P19367)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
HK1

# Metabolic_Enzyme_9_Geneatlas_id:
HK1

# Metabolic_Enzyme_9_hgnc_id:
HGNC:4922

# Metabolic_Enzyme_9_PDB_ID:
1HKB

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding

# Metabolic_Enzyme_9_Gene_Sequence:
>2754 bp
ATGATCGCCGCGCAGCTCCTGGCCTATTACTTCACGGAGCTGAAGGATGACCAGGTCAAA
AAGATTGACAAGTATCTGTATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATG
ACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTAATCCAACAGCCACA
GTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGAAAAGGGAGATTTC
ATTGCCCTGGATCTTGGTGGGTCTTCCTTTCGAATTCTGCGGGTGCAAGTGAATCATGAG
AAAAACCAGAATGTTCACATGGAGTCCGAGGTTTATGACACCCCAGAGAACATCGTGCAC
GGCAGTGGAAGCCAGCTTTTTGATCATGTTGCTGAGTGCCTGGGAGATTTCATGGAGAAA
AGGAAGATCAAGGACAAGAAGTTACCTGTGGGATTCACGTTTTCTTTTCCTTGCCAACAA
TCCAAAATAGATGAGGCCATCCTGATCACCTGGACAAAGCGATTTAAAGCGAGCGGAGTG
GAAGGAGCAGATGTGGTCAAACTGCTTAACAAAGCCATCAAAAAGCGAGGGGACTATGAT
GCCAACATCGTAGCTGTGGTGAATGACACAGTGGGCACCATGATGACCTGTGGCTATGAC
GACCAGCACTGTGAAGTCGGCCTGATCATCGGCACTGGCACCAATGCTTGCTACATGGAG
GAACTGAGGCACATTGATCTGGTGGAAGGAGACGAGGGGAGGATGTGTATCAATACAGAA
TGGGGAGCCTTTGGAGACGATGGATCATTAGAAGACATCCGGACAGAGTTTGACAGGGAG
ATAGACCGGGGATCCCTCAACCCTGGAAAACAGCTGTTTGAGAAGATGGTCAGTGGCATG
TACTTGGGAGAGCTGGTTCGACTGATCCTAGTCAAGATGGCCAAGGAGGGCCTCTTATTT
GAAGGGCGGATCACCCCGGAGCTGCTCACCCGAGGGAAGTTTAACACCAGTGATGTGTCA
GCCATCGAAAAGAATAAGGAAGGCCTCCACAATGCCAAAGAAATCCTGACCCGCCTGGGA
GTGGAGCCGTCCGATGATGACTGTGTCTCAGTCCAGCACGTTTGCACCATTGTCTCATTT
CGCTCAGCCAACTTGGTGGCTGCCACACTGGGCGCCATCTTGAACCGCCTGCGTGATAAC
AAGGGCACACCCAGGCTGCGGACCACGGTTGGTGTCGACGGATCTCTTTACAAGACGCAC
CCACAGTATTCCCGGCGTTTCCACAAGACTCTAAGGCGCTTGGTGCCAGACTCCGATGTG
CGCTTCCTCCTCTCGGAGAGTGGCAGCGGCAAGGGGGCTGCCATGGTGACGGCGGTGGCC
TACCGCTTGGCCGAGCAGCACCGGCAGATAGAGGAGACCCTGGCTCATTTCCACCTCACC
AAAGACATGCTGCTGGAGGTGAAGAAGAGGATGCGGGCCGAGATGGAGCTGGGGCTGAGG
AAGCAGACGCACAACAATGCCGTGGTTAAGATGCTGCCCTCCTTCGTCCGGAGAACTCCC
GACGGGACCGAGAATGGTGACTTCTTGGCCCTGGATCTTGGAGGAACCAATTTCCGTGTG
CTGCTGGTGAAAATCCGTAGTGGGAAAAAGAGAACGGTGGAAATGCACAACAAGATCTAC
GCCATTCCTATTGAAATCATGCAGGGCACTGGGGAAGAGCTGTTTGATCACATTGTCTCC
TGCATCTCTGACTTCTTGGACTACATGGGGATCAAAGGCCCCAGGATGCCTCTGGGCTTC
ACGTTCTCATTTCCCTGCCAGCAGACGAGTCTGGACGCGGGAATCTTGATCACGTGGACA
AAGGGTTTTAAGGCAACAGACTGCGTGGGCCACGATGTAGTCACCTTACTAAGGGATGCG
ATAAAAAGGAGAGAGGAATTTGACCTGGACGTGGTGGCTGTGGTCAACGACACAGTGGGC
ACCATGATGACCTGTGCTTATGAGGAGCCCACCTGTGAGGTTGGACTCATTGTTGGGACC
GGCAGCAATGCCTGCTACATGGAGGAGATGAAGAACGTGGAGATGGTGGAGGGGGACCAG
GGGCAGATGTGCATCAACATGGAGTGGGGGGCCTTTGGGGACAACGGGTGTCTGGATGAT
ATCAGGACACACTACGACAGACTGGTGAACGAATATTCCCTAAATGCTGGGAAACAAAGG
TATGAGAAGATGATCAGTGGTATGTACCTGGGTGAAATCGTCCGCAACATCTTAATCGAC
TTCACCAAGAAGGGATTCCTCTTCCGAGGGCAGATCTCTGAGACGATGAAGACCCGGGGC
ATCTTTGAGACCAAGTTTCTCTCTCAGATCGAGAGTGACCGATTAGCACTGCTCCAGGTC
CGGGCTATCCTCCAGCAGCTAGGTCTGAATAGCACCTGCGATGACAGTATCCTCGTCAAG
ACAGTGTGCGGGGTGGTGTCCAGGAGGGCCGCACAGCTGTGTGGCGCAGGCATGGCTGCG
GTTGTGGATAAGATCCGCGAGAACAGAGGACTGGACCGTCTGAATGTGACTGTGGGAGTG
GACGGGACACTCTACAAGCTTCATCCACACTTCTCCAGAATCATGCACCAGACGGTGAAG
GAACTGTCACCAAAATGTAACGTGTCCTTCCTCCTGTCTGAGGATGGCAGCGGCAAGGGG
GCCGCCCTCATCACGGCCGTGGGCGTGCGGTTACGCACAGAGGCAAGCAGCTAA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
M75126

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_9_Locus:
10q22

# Metabolic_Enzyme_9_SNPs:
rs906220; rs1054203; rs748235; rs12254258; rs1133189; rs10998760; rs34616021; rs14006; rs2394539; rs10998704; rs6480394; rs10762281; rs3812689; rs10998703; rs4746834; rs7893994; rs4469773; rs7914134; rs1472817; rs2894081; rs11815833; rs2394540; rs10823332; rs10762280; rs10762277; rs2394543; rs7897621; rs4746837; rs7068435; rs13139; rs1876257; rs5030916; rs10998700; rs11819086; rs12257270; rs2394545; rs11818777; rs10998699; rs10762275; rs7907176; rs7903625; rs12216; rs10998702; rs1472819; rs2394541; rs7095428; rs1472816; rs2394538; rs10823333; rs10998692; rs11813648; rs11818779; rs10762276; rs10823329; rs12242964; rs12242332; rs10762273; rs1472818; rs11818927; rs10998684; rs2394535; rs11815263; rs7095547; rs10823328; rs10823335; rs12751; rs10823331; rs10998694; rs11815943; rs11815513; rs4746833; rs12244771; rs10762278; rs10823334; rs2894080; rs11818799; rs5030886; rs2394537; rs2089356; rs10998696; rs10998689; rs11819674; rs10762279; rs7092374; rs10823330; rs2002905; rs12263326; rs4372334; rs10998691; rs11816714; rs12265826; rs4746836; rs10740318; rs7095424; rs12218331; rs7907242; rs5030949; rs11816128; rs7095579; rs12241382; rs1867972; rs2084274; rs1867971; rs906215; rs1867975; rs749108; rs2305198; rs4537657; rs7084213; rs11596193; rs7909192; rs2305196; rs1227938; rs7072268; rs10823348; rs10159541; rs7094651; rs7084363; rs1900466; rs12414591; rs10762288; rs10733851; rs7921170; rs7921060; rs7095140; rs749107; rs10762282; rs2015803; rs6480396; rs6480404; rs1867973; rs3812691; rs10998738; rs11595647; rs11812791; rs10823360; rs9664217; rs4745988; rs10823350; rs10159477; rs10823357; rs12243794; rs4746848; rs10998730; rs7097078; rs749105; rs7071731; rs4745987; rs16926253; rs7076563; rs3793846; rs10998725; rs2305197; rs4072508; rs7898060; rs11597346; rs6480400; rs11596110; rs7092155; rs2394560; rs4745981; rs4589168; rs11595655; rs10823343; rs3829185; rs11599680; rs10823354; rs6480403; rs12262904; rs10998751; rs4746838; rs10823349; rs11819564; rs10762292; rs1867974; rs906216; rs2278745; rs10998754; rs10823356; rs10159540; rs11818709; rs4746839; rs7079157; rs7088667; rs7094214; rs11599150; rs4746846; rs11598389; rs1900467; rs10823345; rs12265560; rs10762290; rs2394561; rs10823355; rs10823340; rs12244847; rs2305199; rs4746841; rs749106; rs7913579; rs7076745; rs3793845; rs10823341; rs11596587; rs11596868; rs10998720; rs7905437; rs7917338; rs6480402; rs7914033; rs16926244; rs3829183; rs7067927; rs7912524; rs12416320; rs16926252; rs12571072; rs4746849; rs11596199; rs10823339; rs10998728; rs6480398; rs10823342; rs11813750; rs12415409; rs10998739; rs10762284; rs10998742; rs10823353; rs10998741; rs10128334; rs7895704; rs7902303; rs4745982; rs11818471; rs10159490; rs4746847; rs10128330; rs10762285; rs5030915; rs10998719; rs12252483; rs7072349; rs6480399; rs4745986; rs10998752; rs10998710; rs7905515; rs3793847; rs7904932; rs17489768; rs12255367; rs10998747; rs34895304; rs12240847; rs10823358; rs17567544; rs906221; rs12251732; rs10823338; rs10823351; rs9299503; rs10998726; rs10998735; rs12253797; rs10998706; rs7067730; rs12248026; rs12243312; rs12262357; rs4471325; rs11599654; rs12252916; rs3793844; rs7081302; rs10998715; rs12262687; rs16926246; rs7905243; rs10823352; rs10823337; rs10762286; rs10823359; rs10128513; rs10998748; rs17476364; rs10159599; rs11597225; rs10823344; rs10998736; rs7902486; rs12220752; rs7094943; rs7920991; rs10998731; rs16926242; rs10998723; rs12254195; rs10762293; rs4746851; rs7899625; rs16926292; rs10159598; rs2135589; rs10823347; rs4364944; rs7077298; rs10998716; rs16926249; rs11599655; rs12243716; rs7097551; rs10998744; rs10762283; rs12771121; rs7083032; rs12411628; rs10762287; rs10762291; rs7913272; rs12355201; rs5030917; rs10998733; rs10998740; rs1108272; rs4746850; rs11819352; rs10823346; rs12778692; rs6480397; rs11593167; rs11816511; rs11812380; rs10998724; rs2394534; rs1054202; rs34410083; rs35378602; rs41279658; rs12356717; rs35387972; rs12243655; rs35468118; rs1803712; rs10998693; rs35379025; rs5785909; rs35517819; rs35080013; rs34434447; rs10998687; rs28558590; rs12357729; rs12219469; rs12780875; rs34997376; rs35104096; rs12780655; rs10762274; rs34150929; rs12263929; rs10998698; rs10998690; rs10716029; rs2394542; rs12221426; rs4282890; rs12569892; rs7916281; rs35143457; rs2394536; rs36020756; rs3086615; rs7083056; rs10998695; rs1810023; rs2063048; rs36007468; rs10998688; rs11286202; rs35585147; rs28422950; rs35431404; rs12242466; rs35264480; rs35699014; rs14382; rs34382339; rs34539856; rs5785910; rs4745980; rs4638197; rs5785908; rs34031234; rs12262447; rs11815616; rs34736420; rs10672043; rs35376303; rs34164890; rs12253706; rs7914285; rs4622145; rs34547808; rs11556966; rs34453032; rs10998685; rs12241639; rs10998686; rs10998701; rs10998697; rs10400052; rs12268098; rs11819094; rs35607669; rs7905200; rs2394544; rs3750793; rs35895463; rs7083200; rs12220458; rs7914344; rs12259682; rs12571243; rs7894213; rs34610927; rs12253579; rs35804876; rs41279664; rs5030950; rs34938278; rs12242474; rs34931035; rs12780492; rs35306200; rs34327925; rs1057566; rs11819447; rs10668853; rs4453112; rs41279662; rs12252651; rs10998745; rs36104030; rs12247331; rs33984080; rs4366384; rs35347843; rs35619781; rs11592707; rs34834335; rs891564; rs34694521; rs35135619; rs5785912; rs34040090; rs35627580; rs10578071; rs6143971; rs1867970; rs12780794; rs10998734; rs11816980; rs35368978; rs10998714; rs11597178; rs34605664; rs10998756; rs7478446; rs34064357; rs11497990; rs10688656; rs7911813; rs7476246; rs12254694; rs34142395; rs35932296; rs1867976; rs12252489; rs35684348; rs35802626; rs36006142; rs35233497; rs10998757; rs16926233; rs10998709; rs10998722; rs12240898; rs34164799; rs34068824; rs41435648; rs35975244; rs34124986; rs35131910; rs11819725; rs11424399; rs906223; rs7476298; rs35300718; rs10998729; rs36006221; rs5785913; rs11597418; rs34156889; rs11592659; rs10679551; rs10159538; rs10998755; rs35790367; rs36124339; rs5030919; rs16926269; rs41279656; rs12264809; rs35680310; rs11596222; rs34391428; rs36012744; rs34821837; rs10580275; rs10998718; rs12769898; rs7090983; rs34729523; rs35983460; rs11598601; rs34428846; rs11597672; rs35532806; rs10998708; rs35337416; rs2089357; rs3086649; rs10998746; rs10684489; rs5019350; rs12248865; rs35385375; rs35827992; rs11400433; rs10128509; rs35246952; rs35351562; rs33920450; rs10998707; rs35258842; rs10998737; rs16926245; rs34348007; rs12765788; rs12248628; rs7911786; rs10998743; rs17489948; rs34969484; rs6480401; rs12258259; rs34967951; rs11591962; rs41279660; rs35833065; rs10998759; rs3086686; rs12782422; rs10998711; rs35024696; rs34137364; rs33920304; rs35326884; rs34301815; rs35860582; rs906222; rs35929312; rs7093863; rs11389885; rs10998705; rs3812690; rs7081298; rs2894082; rs12360012; rs34309168; rs12769387; rs41279654; rs36096331; rs34767311; rs36022169; rs12247649; rs10542467; rs12770156; rs12259309; rs12245854; rs35510140; rs10998750; rs12357558; rs34815317; rs35215102; rs3956966; rs35733293; rs12765993; rs4745983; rs11295023; rs5019351; rs10998753; rs10998727; rs12769386; rs11421011; rs12243746; rs34133918; rs12356440; rs34966318; rs35451830; rs7094375; rs12359036; rs12763363; rs34977762; rs10047284; rs10998758; rs12098572; rs35694546; rs10603617; rs10531274; rs35035641; rs10998717; rs11593738; rs12257925; rs5030918; rs34367822; rs35534322; rs4745984; rs7072757; rs12243670; rs7088597; rs11267589; rs12411524; rs35376932; rs34620768; rs10823336; rs11597926; rs10998712; rs28510843; rs10536437; rs35922004; rs12263320; rs35828572; rs12246003; rs7094252; rs6480405; rs10998749; rs10159790; rs35341389; rs10998713; rs12264596; rs2278744; rs34085490; rs4746840; rs34767665; rs10998732; rs35490740; rs35026222; rs34941976; rs34818501; rs12264010; rs34125846; rs10998682; rs34564828; rs34015903; rs34747241; rs1000251; rs10740320; rs10998677; rs10998679; rs10998762; rs11813340; rs11815413; rs11817458; rs12244723; rs1227958; rs12776509; rs12781552; rs1549797; rs1549798; rs1549799; rs16926201; rs2278746; rs2611; rs34690134; rs35008643; rs3740601; rs3793849; rs3793850; rs3793851; rs4603200; rs4644560; rs4746832; rs6480393; rs7097827; rs7097971; rs7098065; rs906219; rs986525

# Metabolic_Enzyme_9_General_References:
3207429; 9531504; 1637300; 1985912; 9028305; 10978502; 8706938; 9493266; 9735292; 10574795; 10686099; 7655856

# Metabolic_Enzyme_9_References:
17043805; 17049721; 17111003

# Metabolic_Enzyme_10_ID:
6981

# Metabolic_Enzyme_10_Name:
Dipeptidyl peptidase 4

# Metabolic_Enzyme_10_Synonyms:
Dipeptidyl peptidase IV; DPP IV; T-cell activation antigen CD26; TP103; Adenosine deaminase complexing protein 2; ADABP[Contains: Dipeptidyl peptidase 4 membrane form; Dipeptidyl peptidase IV membrane form; Dipeptidyl peptidase 4 soluble form; Dipeptidyl peptidase IV soluble form]

# Metabolic_Enzyme_10_Gene_Name:
DPP4

# Metabolic_Enzyme_10_Protein_Sequence:
>Dipeptidyl peptidase 4
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSL
RWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNY
VKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNL
PSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSF
YSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYL
CDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPS
EPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISN
EYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLY
TLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKY
PLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGT
FEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWE
YYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQIS
KALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP

# Metabolic_Enzyme_10_Number_of_Residues:
766

# Metabolic_Enzyme_10_Molecular_Weight:
88279

# Metabolic_Enzyme_10_Theoretical_pI:
5.92

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  dipeptidyl-peptidase IV activity
Function:  serine-type peptidase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
Function:  prolyl oligopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_10_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Plays a role in T-cell activation

# Metabolic_Enzyme_10_Pathway:
Not Available

# Metabolic_Enzyme_10_Reaction:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00930:DPPIV_N;
PF00326:Peptidase_S9

# Metabolic_Enzyme_10_Signals:
1-28

# Metabolic_Enzyme_10_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 3.4.14.5

# Metabolic_Enzyme_10_GenBank_ID_Protein:
535388

# Metabolic_Enzyme_10_SwissProt_ID:
DPP4_HUMAN (P27487)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
DPP4

# Metabolic_Enzyme_10_Geneatlas_id:
DPP4

# Metabolic_Enzyme_10_hgnc_id:
HGNC:3009

# Metabolic_Enzyme_10_PDB_ID:
2BGR

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists in a soluble form

# Metabolic_Enzyme_10_Gene_Sequence:
>2301 bp
ATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATC
ATCACCGTGCCCGTGGTTCTGCTGAACAAAGGCACAGATGATGCTACAGCTGACAGTCGC
AAAACTTACACTCTAACTGATTACTTAAAAAATACTTATAGACTGAAGTTATACTCCTTA
AGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAAT
GCTGAATATGGAAACAGCTCAGTTTTCTTGGAGAACAGTACATTTGATGAGTTTGGACAT
TCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTTATTCTCTTAGAATACAACTAC
GTGAAGCAATGGAGGCATTCCTACACAGCTTCATATGACATTTATGATTTAAATAAAAGG
CAGCTGATTACAGAAGAGAGGATTCCAAACAACACACAGTGGGTCACATGGTCACCAGTG
GGTCATAAATTGGCATATGTTTGGAACAATGACATTTATGTTAAAATTGAACCAAATTTA
CCAAGTTACAGAATCACATGGACGGGGAAAGAAGATATAATATATAATGGAATAACTGAC
TGGGTTTATGAAGAGGAAGTCTTCAGTGCCTACTCTGCTCTGTGGTGGTCTCCAAACGGC
ACTTTTTTAGCATATGCCCAATTTAACGACACAGAAGTCCCACTTATTGAATACTCCTTC
TACTCTGATGAGTCACTGCAGTACCCAAAGACTGTACGGGTTCCATATCCAAAGGCAGGA
GCTGTGAATCCAACTGTAAAGTTCTTTGTTGTAAATACAGACTCTCTCAGCTCAGTCACC
AATGCAACTTCCATACAAATCACTGCTCCTGCTTCTATGTTGATAGGGGATCACTACTTG
TGTGATGTGACATGGGCAACACAAGAAAGAATTTCTTTGCAGTGGCTCAGGAGGATTCAG
AACTATTCGGTCATGGATATTTGTGACTATGATGAATCCAGTGGAAGATGGAACTGCTTA
GTGGCACGGCAACACATTGAAATGAGTACTACTGGCTGGGTTGGAAGATTTAGGCCTTCA
GAACCTCATTTTACCCTTGATGGTAATAGCTTCTACAAGATCATCAGCAATGAAGAAGGT
TACAGACACATTTGCTATTTCCAAATAGATAAAAAAGACTGCACATTTATTACAAAAGGC
ACCTGGGAAGTCATCGGGATAGAAGCTCTAACCAGTGATTATCTATACTACATTAGTAAT
GAATATAAAGGAATGCCAGGAGGAAGGAATCTTTATAAAATCCAACTTAGTGACTATACA
AAAGTGACATGCCTCAGTTGTGAGCTGAATCCGGAAAGGTGTCAGTACTATTCTGTGTCA
TTCAGTAAAGAGGCGAAGTATTATCAGCTGAGATGTTCCGGTCCTGGTCTGCCCCTCTAT
ACTCTACACAGCAGCGTGAATGATAAAGGGCTGAGAGTCCTGGAAGACAATTCAGCTTTG
GATAAAATGCTGCAGAATGTCCAGATGCCCTCCAAAAAACTGGACTTCATTATTTTGAAT
GAAACAAAATTTTGGTATCAGATGATCTTGCCTCCTCATTTTGATAAATCCAAGAAATAT
CCTCTACTATTAGATGTGTATGCAGGCCCATGTAGTCAAAAAGCAGACACTGTCTTCAGA
CTGAACTGGGCCACTTACCTTGCAAGCACAGAAAACATTATAGTAGCTAGCTTTGATGGC
AGAGGAAGTGGTTACCAAGGAGATAAGATCATGCATGCAATCAACAGAAGACTGGGAACA
TTTGAAGTTGAAGATCAAATTGAAGCAGCCAGACAATTTTCAAAAATGGGATTTGTGGAC
AACAAACGAATTGCAATTTGGGGCTGGTCATATGGAGGGTACGTAACCTCAATGGTCCTG
GGATCGGGAAGTGGCGTGTTCAAGTGTGGAATAGCCGTGGCGCCTGTATCCCGGTGGGAG
TACTATGACTCAGTGTACACAGAACGTTACATGGGTCTCCCAACTCCAGAAGACAACCTT
GACCATTACAGAAATTCAACAGTCATGAGCAGAGCTGAAAATTTTAAACAAGTTGAGTAC
CTCCTTATTCATGGAACAGCAGATGATAACGTTCACTTTCAGCAGTCAGCTCAGATCTCC
AAAGCCCTGGTCGATGTTGGAGTGGATTTCCAGGCAATGTGGTATACTGATGAAGACCAT
GGAATAGCTAGCAGCACAGCACACCAACATATATATACCCACATGAGCCACTTCATAAAA
CAATGTTTCTCTTTACCTTAG

# Metabolic_Enzyme_10_GenBank_ID_Gene:
U13735

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_10_Locus:
2q24.3

# Metabolic_Enzyme_10_SNPs:
rs17574; rs2302872; rs12617336; rs13821; rs16846222; rs13015258; rs2287509; rs2268894; rs2300757; rs2268890; rs759717; rs1014444; rs2970933; rs2302873; rs3788976; rs12469968; rs10166311; rs5022713; rs2268888; rs2909448; rs2300755; rs7565794; rs4140685; rs2909449; rs2909450; rs6432707; rs2111850; rs12692646; rs10930040; rs1014445; rs6744557; rs10930041; rs10166124; rs12617656; rs2284873; rs2284872; rs16822665; rs6737128; rs1861975; rs6432708; rs11900409; rs2042069; rs6741949; rs2284871; rs2284868; rs7566261; rs2300758; rs4664446; rs10490422; rs873826; rs3788980; rs12621633; rs3788979; rs2268889; rs741529; rs17759529; rs13409045; rs6727102; rs1861978; rs2300753; rs6729733; rs11677330; rs7573951; rs12618391; rs2216447; rs2111849; rs16846261; rs12615031; rs16846234; rs7604582; rs2909447; rs2284869; rs4664443; rs2389643; rs11884002; rs1861976; rs2160927; rs2970932; rs6733162; rs1558957; rs7608798; rs12618149; rs12995983; rs16846230; rs11695645; rs11691329; rs7565475; rs3788978; rs2909451; rs2284870; rs12469930; rs2909445; rs1861977; rs2909446; rs2193681; rs13387537; rs2268891; rs12614077; rs2970931; rs2268885; rs12995636; rs16846253; rs13401660; rs6709308; rs6709208; rs1129599; rs1129598; rs17848907; rs2193680; rs17848910; rs41268649; rs35819043; rs34158426; rs41268645; rs11537990; rs956791; rs35635667; rs34282135; rs11340563; rs2300754; rs35429704; rs3831864; rs10558843; rs17848906; rs2909452; rs35559558; rs34536659; rs17848914; rs34067882; rs17848920; rs3217202; rs35839001; rs34413066; rs2302874; rs34779498; rs10647762; rs17848917; rs34955575; rs41268647; rs35532157; rs34436413; rs10526211; rs28668403; rs34315066; rs17848909; rs34561857; rs2268893; rs2216446; rs738107; rs28649469; rs3216773; rs35128070; rs10564811; rs34843867; rs35175377; rs6719154; rs2268884; rs12467848; rs34614786; rs11343430; rs35605823; rs11288272; rs2268887; rs10930039; rs727204; rs34869697; rs35591385; rs2892816; rs34193997; rs35570904; rs6725970; rs35363685; rs34697128; rs34697366; rs5835890; rs4364036; rs35628661; rs35455293; rs34650018; rs2909454; rs34034181; rs3833425; rs35395080; rs6731198; rs3216641; rs17848912; rs34902303; rs2268886; rs17848919; rs13020751; rs2300756; rs34450218; rs35326408; rs4664445; rs3885571; rs2909453; rs36066702; rs3919564; rs2080714; rs2268892; rs4637138; rs17848923; rs11437441; rs13015763; rs7578313; rs35052138; rs17848911; rs35058949; rs34768876; rs956792; rs17848922; rs34440743; rs11889971; rs13020787; rs3885566; rs3216640; rs41268651; rs34775433; rs17848916; rs35280626; rs12052902; rs13414943; rs35767547; rs34906971; rs35644200; rs35869045; rs13401492; rs10930042; rs12622869; rs1558958; rs1558959; rs1558960; rs1861979; rs2098526; rs2193677; rs2302871; rs2909443; rs2909455; rs7593348

# Metabolic_Enzyme_10_General_References:
1352704; 7927537; 1352530; 8094732; 1347043; 1977364; 7487939; 1677636; 8096237

# Metabolic_Enzyme_10_References:
17065392

# Metabolic_Enzyme_11_ID:
5442

# Metabolic_Enzyme_11_Name:
Glucokinase

# Metabolic_Enzyme_11_Synonyms:
Hexokinase-4; Hexokinase type IV; HK IV; HK4; Hexokinase-D

# Metabolic_Enzyme_11_Gene_Name:
GCK

# Metabolic_Enzyme_11_Protein_Sequence:
>Glucokinase
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ

# Metabolic_Enzyme_11_Number_of_Residues:
465

# Metabolic_Enzyme_11_Molecular_Weight:
52192

# Metabolic_Enzyme_11_Theoretical_pI:
4.85

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Not Available

# Metabolic_Enzyme_11_Specific_Function:
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage

# Metabolic_Enzyme_11_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism;
 map00521  Streptomycin biosynthesis

# Metabolic_Enzyme_11_Reaction:
ATP + D-glucose = ADP + D-glucose 6-phosphate

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00349:Hexokinase_1;
PF03727:Hexokinase_2

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.7.1.2

# Metabolic_Enzyme_11_GenBank_ID_Protein:
179427

# Metabolic_Enzyme_11_SwissProt_ID:
HXK4_HUMAN (P35557)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
GCK

# Metabolic_Enzyme_11_Geneatlas_id:
GCK

# Metabolic_Enzyme_11_hgnc_id:
HGNC:4195

# Metabolic_Enzyme_11_PDB_ID:
1V4T

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Not Available

# Metabolic_Enzyme_11_Gene_Sequence:
>1398 bp
ATGCTGGACGACAGAGCCAGGATGGAGGCCGCCAAGAAGGAGAAGGTAGAGCAGATCCTG
GCAGAGTTCCAGCTGCAGGAGGAGGACCTGAAGAAGGTGATGAGACGGATGCAGAAGGAG
ATGGACCGCGGCCTGAGGCTGGAGACCCATGAAGAGGCCAGTGTGAAGATGCTGCCCACC
TACGTGCGCTCCACCCCAGAAGGCTCAGAAGTCGGGGACTTCCTCTCCCTGGACCTGGGT
GGCACTAACTTCAGGGTGATGCTGGTGAAGGTGGGAGAAGGTGAGGAGGGGCAGTGGAGC
GTGAAGACCAAACACCAGATGTACTCCATCCCCGAGGACGCCATGACCGGCACTGCTGAG
ATGCTCTTCGACTACATCTCTGAGTGCATCTCCGACTTCCTGGACAAGCATCAGATGAAA
CACAAGAAGCTGCCCCTGGGCTTCACCTTCTCCTTTCCTGTGAGGCACGAAGACATCGAT
AAGGGCATCCTTCTCAACTGGACCAAGGGCTTCAAGGCCTCAGGAGCAGAAGGGAACAAT
GTCGTGGGGCTTCTGCGAGACGCTATCAAACGGAGAGGGGACTTTGAAATGGATGTGGTG
GCAATGGTGAATGACACGGTGGCCACGATGATCTCCTGCTACTACGAAGACCATCAGTGC
GAGGTCGGCATGATCGTGGGCACGGGCTGCAATGCCTGCTACATGGAGGAGATGCAGAAT
GTGGAGCTGGTGGAGGGGGACGAGGGCCGCATGTGCGTCAATACCGAGTGGGGCGCCTTC
GGGGACTCCGGCGAGCTGGACGAGTTCCTGCTGGAGTATGACCGCCTGGTGGACGAGAGC
TCTGCAAACCCCGGTCAGCAGCTGTATGAGAAGCTCATAGGTGGCAAGTACATGGGCGAG
CTGGTGCGGCTTGTGCTGCTCAGGCTCGTGGACGAAAACCTGCTCTTCCACGGGGAGGCC
TCCGAGCAGCTGCGCACACGCGGAGCCTTCGAGACGCGCTTCGTGTCGCAGGTGGAGAGC
GACACGGGCGACCGCAAGCAGATCTACAACATCCTGAGCACGCTGGGGCTGCGACCCTCG
ACCACCGACTGCGACATCGTGCGCCGCGCCTGCGAGAGCGTGTCTACGCGCGCTGCGCAC
ATGTGCTCGGCGGGGCTGGCGGGCGTCATCAACCGCATGCGCGAGAGCCGCAGCGAGGAC
GTAATGCGCATCACTGTGGGCGTGGATGGCTCCGTGTACAAGCTGCACCCCAGCTTCAAG
GAGCGGTTCCATGCCAGCGTGCGCAGGCTGACGCCCAGCTGCGAGATCACCTTCATCGAG
TCGGAGGAGGGCAGTGGCCGGGGCGCGGCCCTGGTCTCGGCGGTGGCCTGTAAGAAGGCC
TGTATGCTGGGCCAGTGA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
M88011

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_11_Locus:
7p15.3-p15.1

# Metabolic_Enzyme_11_SNPs:
rs2908275; rs2908276; rs13306390; rs13306391; rs2284776; rs2268572; rs2908290; rs741038; rs758989; rs2908289; rs2070971; rs2908296; rs758985; rs2268576; rs2268574; rs2300586; rs1990458; rs2908297; rs1303722; rs3808319; rs2300584; rs2971672; rs2284777; rs12540369; rs2268575; rs2908298; rs2010825; rs12535229; rs7793213; rs2908292; rs2971677; rs3808323; rs12534623; rs2971679; rs2268570; rs2908274; rs730497; rs11766576; rs3808322; rs12673242; rs2971678; rs17832252; rs2268573; rs2971674; rs2971671; rs4724290; rs2041547; rs758987; rs13239289; rs2268569; rs3808320; rs17172566; rs10246064; rs758988; rs16881016; rs2300587; rs3808321; rs887688; rs2284773; rs758986; rs887686; rs2244164; rs10259649; rs12702069; rs2284769; rs6952751; rs11768239; rs2080033; rs2971676; rs887687; rs2971675; rs2908293; rs6945550; rs13306387; rs2908291; rs12702068; rs12534104; rs2215644; rs1799884; rs1476891; rs2908277; rs12702070; rs34389297; rs13306389; rs35548117; rs34322372; rs13306388; rs13306393; rs41282709; rs35140467; rs13306392; rs35521280; rs34255297; rs28639899; rs741039; rs5883891; rs2284771; rs34710012; rs34691097; rs2971670; rs34288160; rs34574619; rs34807880; rs3216596; rs34265547; rs34672149; rs34973571; rs35368425; rs13227198; rs36094778; rs35276355; rs28491181; rs34859037; rs34947625; rs5883890; rs35079658; rs34780996; rs35606092; rs34124036; rs2971680; rs3065183; rs41282712; rs35786405; rs4724291; rs3840676; rs34675661; rs2284778; rs11447509; rs2284779; rs2268577; rs10680351; rs1303721; rs2908294; rs34114506; rs1799831; rs36084943; rs2908295; rs11974018; rs34380942; rs36118223; rs35568119; rs2284772; rs34185745; rs11772934; rs35262363; rs11412934; rs35723429; rs2284774; rs41282715; rs36193808; rs11287012; rs6971410; rs41314139; rs2284775; rs35688609; rs13239987; rs34178750; rs28684786; rs35620913; rs35907141; rs34976798; rs34359315; rs3779606; rs13306394; rs3840677; rs1076439; rs36205687; rs35670475; rs11372006; rs36205684; rs2971681; rs36205686; rs36205690; rs36205688; rs1008384; rs12669054; rs17135975; rs17136076; rs17172591; rs17769733; rs2080032; rs2908278; rs2908286; rs2971669; rs3757838; rs3757840; rs4397301; rs4607517; rs6953355; rs6975024; rs735670; rs737525; rs741033; rs741034; rs741035; rs741036; rs741037; rs758983; rs882019; rs882020; rs882021

# Metabolic_Enzyme_11_General_References:
1354840; 1871135; 1511800; 1612194; 1502186; 1464666; 8194664; 1303265; 8454109; 8495817; 8325892; 8446612; 8168652; 9049484; 9662401; 9435328; 10588527; 11106831; 11372010

# Metabolic_Enzyme_11_References:
17127032; 17130482

# Metabolic_Enzyme_12_ID:
8593

# Metabolic_Enzyme_12_Name:
Cytosolic beta-glucosidase

# Metabolic_Enzyme_12_Synonyms:
Cytosolic beta-glucosidase- like protein 1

# Metabolic_Enzyme_12_Gene_Name:
GBA3

# Metabolic_Enzyme_12_Protein_Sequence:
>Cytosolic betaglucosidase
MAFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWE
EDLKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYH
FDLPQTLEDQGGWLSEAIIESFDKYAQFCFSTFGDRVKQWITINEANVLSVMSYDLGMFP
PGIPHFGTGGYQAAHNLIKAHARSWHSYDSLFRKKQKGMVSLSLFAVWLEPADPNSVSDQ
EAAKRAITFHLDLFAKPIFIDGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGT
ADFFAVQYYTTRLIKYQENKKGELGILQDAEIEFFPDPSWKNVDWIYVVPWGVCKLLKYI
KDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYCAWSLL
DNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLEAHL

# Metabolic_Enzyme_12_Number_of_Residues:
469

# Metabolic_Enzyme_12_Molecular_Weight:
53696

# Metabolic_Enzyme_12_Theoretical_pI:
5.33

# Metabolic_Enzyme_12_GO_Classification:
>>>
 Function:  glucosidase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Carbohydrate transport and metabolism

# Metabolic_Enzyme_12_Specific_Function:
Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens

# Metabolic_Enzyme_12_Pathway:
map00460  Cyanoamino acid metabolism
 map00500  Starch and sucrose metabolism
 map00940  Stilbene, coumarine and lignin biosynthesis

# Metabolic_Enzyme_12_Reaction:
Hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00232:Glyco_hydro_1

# Metabolic_Enzyme_12_Signals:
Not Available

# Metabolic_Enzyme_12_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 3.2.1.21

# Metabolic_Enzyme_12_GenBank_ID_Protein:
11559218

# Metabolic_Enzyme_12_SwissProt_ID:
GBA3_HUMAN (Q9H227)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
GBA3

# Metabolic_Enzyme_12_Geneatlas_id:
GBA3

# Metabolic_Enzyme_12_hgnc_id:
HGNC:19069

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Cytoplasm; cytosol

# Metabolic_Enzyme_12_Gene_Sequence:
>1410 bp
ATGGCTTTCCCTGCAGGATTTGGATGGGCGGCAGCCACTGCAGCTTATCAAGTAGAAGGA
GGCTGGGATGCAGATGGAAAAGGCCCTTGTGTCTGGGACACATTTACTCATCAGGGAGGA
GAGAGAGTTTTCAAGAACCAGACTGGCGATGTAGCTTGTGGCAGCTACACTCTGTGGGAG
GAAGATTTGAAATGTATCAAACAGCTTGGATTGACTCATTACCGCTTCTCTCTTTCCTGG
TCACGTCTGTTACCTGATGGGACGACAGGTTTCATCAACCAGAAAGGAATTGATTATTAC
AACAAGATCATCGATGATTTGTTAAAAAATGGGGTTACTCCCATTGTGACCCTCTACCAC
TTTGATTTGCCTCAGACTTTAGAAGACCAAGGAGGTTGGTTGTCAGAGGCAATCATTGAA
TCCTTTGACAAATATGCTCAGTTTTGCTTCAGTACCTTTGGGGATCGTGTCAAGCAGTGG
ATCACCATAAATGAAGCTAATGTTCTTTCTGTGATGTCATATGACTTAGGTATGTTTCCT
CCGGGTATCCCTCACTTTGGGACTGGAGGTTATCAGGCAGCTCATAATTTGATTAAGGCT
CATGCCAGATCCTGGCACAGCTATGATTCCTTATTTCGAAAAAAGCAGAAAGGTATGGTG
TCTCTATCACTTTTTGCGGTCTGGTTGGAACCAGCAGATCCCAACTCAGTGTCTGACCAG
GAAGCTGCTAAAAGAGCCATCACTTTCCATCTGGATTTATTTGCTAAACCCATATTCATC
GATGGTGATTATCCTGAAGTTGTCAAGTCTCAGATTGCCTCCATGAGTCAAAAGCAAGGC
TATCCATCATCGAGGCTTCCAGAATTCACTGAAGAAGAGAAGAAAATGATCAAAGGCACT
GCTGATTTTTTTGCTGTGCAATATTATACAACTCGCTTAATCAAGTACCAGGAGAACAAG
AAAGGAGAACTAGGTATTCTCCAGGATGCGGAAATTGAATTTTTTCCAGATCCATCTTGG
AAAAATGTGGATTGGATCTACGTGGTACCATGGGGAGTATGTAAACTACTGAAATATATT
AAGGATACATATAATAACCCTGTAATTTACATCACTGAGAATGGGTTTCCCCAGAGTGAC
CCAGCGCCTCTTGATGACACTCAACGCTGGGAGTATTTCAGACAAACATTTCAGGAACTG
TTCAAAGCTATCCAACTTGATAAAGTCAATCTTCAAGTATATTGTGCATGGTCTCTTCTG
GATAACTTTGAGTGGAACCAGGGATACAGCAGCCGGTTTGGTCTCTTCCACGTTGATTTT
GAAGACCCAGCTAGACCCCGAGTCCCTTACACATCGGCCAAGGAATATGCCAAGATCATC
CGAAACAATGGCCTTGAAGCACATCTGTAG

# Metabolic_Enzyme_12_GenBank_ID_Gene:
AB017913

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_12_Locus:
4p15.31

# Metabolic_Enzyme_12_SNPs:
rs17612341; rs16873108; rs358231; rs36090352; rs33968830; rs34415331; rs1032147; rs1485826; rs1564931; rs952229; rs2014512; rs358260; rs2013715; rs2127178; rs1385761; rs183084; rs358253; rs9884116; rs1385760; rs358256; rs7688368; rs10030690; rs4103518; rs2306717; rs4582135; rs982215; rs9884549; rs358252; rs7690215; rs7695833; rs453881; rs10025573; rs12500105; rs9994139; rs1032149; rs358233; rs1540614; rs9991992; rs358246; rs1485828; rs4697336; rs1485832; rs11943842; rs6818185; rs12508070; rs4697340; rs7673025; rs6819056; rs370843; rs6854336; rs10000431; rs1468006; rs4697347; rs982557; rs9994229; rs1485829; rs10005717; rs1867937; rs12510908; rs10517005; rs10021978; rs7435211; rs10030375; rs16872974; rs6820730; rs9993345; rs16873014; rs10516412; rs9997307; rs16873132; rs6843078; rs4103517; rs16873068; rs358248; rs11941186; rs6842894; rs7442608; rs6448178; rs17539365; rs358235; rs11942704; rs4697341; rs358255; rs2169909; rs358254; rs1026982; rs16873006; rs358238; rs4697344; rs4697339; rs2875086; rs7356445; rs16872998; rs4697337; rs16873004; rs12645682; rs10007404; rs12498838; rs358247; rs10020177; rs16873011; rs7434290; rs9997684; rs1963996; rs9884970; rs17540321; rs16873092; rs369697; rs10004988; rs16873013; rs10026609; rs16873007; rs16873075; rs16873095; rs420777; rs16873066; rs16873087; rs9991883; rs4697338; rs16872984; rs4146270; rs10015227; rs16873016; rs4697024; rs7688408; rs6840176; rs7439185; rs11935750; rs16873041; rs118834; rs16873090; rs358258; rs7657589; rs34299764; rs16872987; rs12507529; rs17540786; rs16873000; rs16873134; rs16873028; rs16872994; rs4697335; rs16872976; rs4697346; rs17611607; rs11937242; rs11935840; rs358241; rs7661132; rs16873009; rs16873065; rs11935737; rs12510458; rs2011996; rs16873032; rs358240; rs1468007; rs7435037; rs16872991; rs1485827; rs4697023; rs12506107; rs4697025; rs16873063; rs12647646; rs16873138; rs358257; rs16873118; rs7662092; rs358261; rs1843482; rs1601471; rs7699293; rs16873127; rs358239; rs16873017; rs3912484; rs10516996; rs1843483; rs12509499; rs358251; rs2046473; rs16873110; rs16872986; rs11722380; rs16873122; rs16872995; rs9994035; rs4697334; rs1994304; rs16873034; rs12509633; rs358236; rs16873067; rs12503970; rs16873038; rs7657828; rs7682224; rs16872963; rs10012430; rs10049897; rs3209013; rs33911624; rs34413845; rs5015834; rs5856716; rs33944644; rs11414196; rs34442578; rs358250; rs36202439; rs10640126; rs28673279; rs364556; rs6845590; rs33944746; rs9998977; rs34051116; rs13139508; rs10618132; rs28662481; rs423921; rs10677827; rs28429665; rs10712924; rs11930753; rs1843484; rs35563948; rs412817; rs28397010; rs967492; rs12513084; rs181558; rs28609379; rs168579; rs3102828; rs13147871; rs5856715; rs34332650; rs28431961; rs35974580; rs28522756; rs358237; rs7681488; rs28703219; rs35454995; rs28412450; rs11461102; rs4697345; rs34912080; rs13148968; rs28613858; rs12639982; rs28730332; rs28840190; rs35757281; rs5856713; rs2629974; rs6832711; rs2875116; rs34888310; rs35796872; rs358232; rs11386490; rs34724859; rs28594549; rs28463277; rs11283631; rs9784404; rs35926170; rs6840706; rs10010881; rs4697343; rs173362; rs12502544; rs36096852; rs11347404; rs34840405; rs35641861; rs28425513; rs33980589; rs34625767; rs28453711; rs34524103; rs36214849; rs28592887; rs35110151; rs35424492; rs34304977; rs28727493; rs420712; rs6820924; rs3113632; rs10538083; rs10003599; rs12641214; rs11724205; rs6148339; rs34640218; rs34512325; rs5856708; rs34094686; rs380348; rs405255; rs10013028; rs11319298; rs10668171; rs12506085; rs13112304; rs10027984; rs34960363; rs35847308; rs35446375; rs11935776; rs28622534; rs10620801; rs5856714; rs28548658; rs28495660; rs450790; rs34799478; rs1838907; rs35155587; rs16873114; rs35623213; rs11423971; rs34314687; rs35973429; rs12502541; rs35367824; rs35969864; rs5856712; rs10012249; rs384679; rs653102; rs28378518; rs35594178; rs34912444; rs36017868; rs35808974; rs1803666; rs35966633; rs34846827; rs16873140; rs36012017; rs36011739; rs472896; rs7692758; rs10536222; rs3929303; rs4054470; rs10649799; rs3085366; rs7686822; rs28414388; rs28645461; rs4461512; rs380292; rs358259; rs34705166; rs35714003; rs380604; rs4697342; rs28578809; rs34282212; rs36035967; rs33934675; rs3085365; rs3214981; rs35629430; rs9991989; rs28650456; rs34448806; rs10538082; rs34452905; rs11419708; rs35751235; rs647358; rs35644053; rs423076; rs10030119; rs388967; rs28722003; rs34230718; rs11306978; rs28533002; rs28601647; rs385600; rs28397931; rs28565876; rs4602481; rs10027323; rs28818214; rs33941035; rs5856711; rs13112569; rs28473237; rs6811321; rs386002; rs28677984; rs10033886; rs28396160; rs967491; rs10005079; rs1564932; rs1485830; rs34303325; rs10615376; rs28433588; rs433440; rs34593360; rs16872988; rs34725128; rs3947761; rs358234; rs5856709; rs28634696; rs13148343; rs41345844; rs28521767; rs2306716; rs34584599; rs28490192; rs35343762; rs11299335; rs10010877; rs12644397; rs358249; rs35280353; rs1665393; rs1485822; rs13125881; rs10656933; rs10567802; rs371754; rs379779; rs383446; rs28611368; rs34234350; rs10008460; rs10010794; rs10013725; rs10028144; rs10034703; rs1038112; rs1183474; rs12506103; rs12512285; rs1485824; rs16873082; rs1843485; rs1843486; rs1993913; rs2009731; rs2169908; rs2448198; rs3099557; rs3172708; rs358226; rs358227; rs358228; rs358229; rs358230; rs367348; rs369330; rs370806; rs370920; rs371644; rs377718; rs386900; rs387248; rs389012; rs393899; rs400147; rs404384; rs416134; rs420439; rs428091; rs430359; rs4306940; rs432078; rs441110; rs451730; rs650016; rs650077; rs678019; rs6849406; rs6856346; rs7657113; rs7674626; rs7674947; rs7682149; rs7695938; rs7696145

# Metabolic_Enzyme_12_General_References:
11043382; 11389701

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
8603

# Metabolic_Enzyme_13_Name:
Maltase-glucoamylase, intestinal [Includes: Maltase

# Metabolic_Enzyme_13_Synonyms:
Alpha-glucosidase; Glucoamylase; Glucan 1,4-alpha- glucosidase]

# Metabolic_Enzyme_13_Gene_Name:
MGAM

# Metabolic_Enzyme_13_Protein_Sequence:
>Maltaseglucoamylase, intestinal Includes: Maltase
MARKKLKKFTTLEIVLSVLLLVLFIISIVLIVLLAKESLKSTAPDPGTTGTPDPGTTGTP
DPGTTGTTHA
RTTGPPDPGTTGTTPVSAECPVVNELERINCIPDQPPTKATCDQRGCCW
NPQGAVSVPWCYYSKNHSYHV
EGNLVNTNAGFTARLKNLPSSPVFGSNVDNVLLTAEYQ
TSNRFHFKLTDQTNNRFEVPHEHVQSFSGNAA
ASLTYQVEISRQPFSIKVTRRSNNRVL
FDSSIGPLLFADQFLQLSTRLPSTNVYGLGEHVHQQYRHDMNW
KTWPIFNRDTTPNGNG
TNLYGAQTFFLCLEDASGLSFGVFLMNSNAMEVVLQPAPAITYRTIGGILDFYV
FLGNT
PEQVVQEYLELIGRPALPSYWALGFHLSRYEYGTLDNMREVVERNRAAQLPYDVQHADID
YMDER
RDFTYDSVDFKGFPEFVNELHNNGQKLVIIVDPAISNNSSSSKPYGPYDRGSDM
KIWVNSSDGVTPLIGE
VWPGQTVFPDYTNPNCAVWWTKEFELFHNQVEFDGIWIDMNEV
SNFVDGSVSGCSTNNLNNPPFTPRILD
GYLFCKTLCMDAVQHWGKQYDIHNLYGYSMAV
ATAEAAKTVFPNKRSFILTRSTFAGSGKFAAHWLGDNT
ATWDDLRWSIPGVLEFNLFGI
PMVGPDICGFALDTPEELCRRWMQLGAFYPFSRNHNGQGYKDQDPASFG
ADSLLLNSSR
HYLNIRYTLLPYLYTLFFRAHSRGDTVARPLLHEFYEDNSTWDVHQQFLWGPGLLITPVL

DEGAEKVMAYVPDAVWYDYETGSQVRWRKQKVEMELPGDKIGLHLRGGYIFPTQQPNTT
TLASRKNPLGL
IIALDENKEAKGELFWDDGETKDTVANKVYLLCEFSVTQNRLEVNISQ
STYKDPNNLAFNEIKILGTEEP
SNVTVKHNGVPSQTSPTVTYDSNLKVAIITDIDLLLG
EAYTVEWSIKIRDEEKIDCYPDENGASAENCTA
RGCIWEASNSSGVPFCYFVNDLYSVS
DVQYNSHGATADISLKSSVYANAFPSTPVNPLRLDVTYHKNEML
QFKIYDPNKNRYEVP
VPLNIPSMPSSTPEGQLYDVLIKKNPFGIEIRRKSTGTIIWDSQLLGFTFSDMFI
RIST
RLPSKYLYGFGETEHRSYRRDLEWHTWGMFSRDQPPGYKKNSYGVHPYYMGLEEDGSAHG
VLLLNS
NAMDVTFQPLPALTYRTTGGVLDFYVFLGPTPELVTQQYTELIGRPVMVPYWS
LGFQLCRYGYQNDSEIA
SLYDEMVAAQIPYDVQYSDIDYMERQLDFTLSPKFAGFPALI
NRMKADGMRVILILDPAISGNETQPYPA
FTRGVEDDVFIKYPNDGDIVWGKVWPDFPDV
VVNGSLDWDSQVELYRAYVAFPDFFRNSTAKWWKREIEE
LYNNPQNPERSLKFDGMWID
MNEPSSFVNGAVSPGCRDASLNHPPYMPHLESRDRGLSSKTLCMESQQIL
PDGSLVQHY
NVHNLYGWSQTRPTYEAVQEVTGQRGVVITRSTFPSSGRWAGHWLGDNTAAWDQLKKSII
G
MMEFSLFGISYTGADICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWD
VAFVNISRTVLQ
TRYTLLPYLYTLMHKAHTEGVTVVRPLLHEFVSDQVTWDIDSQFLLG
PAFLVSPVLERNARNVTAYFPRA
RWYDYYTGVDINARGEWKTLPAPLDHINLHVRGGYI
LPWQEPALNTHLSRQKFMGFKIALDDEGTAGGWL
FWDDGQSIDTYGKGLYYLASFSASQ
NTMQSHIIFNNYITGTNPLKLGYIEIWGVGSVPVTSVSISVSGMV
ITPSFNNDPTTQVL
SIDVTDRNISLHNFTSLTWISTL

# Metabolic_Enzyme_13_Number_of_Residues:
1857

# Metabolic_Enzyme_13_Molecular_Weight:
209855

# Metabolic_Enzyme_13_Theoretical_pI:
5.14

# Metabolic_Enzyme_13_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Carbohydrate transport and metabolism

# Metabolic_Enzyme_13_Specific_Function:
May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing

# Metabolic_Enzyme_13_Pathway:
map00052  Galactose metabolism
 map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_13_Reaction:
Hydrolysis of terminal, non-reducing 1,4-linked alpha-D-glucose residues with release of alpha-D-glucose

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF01055:Glyco_hydro_31
PF00088:Trefoil

# Metabolic_Enzyme_13_Signals:
1-35

# Metabolic_Enzyme_13_Transmembrane_Regions:
14-34

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 3.2.1.20;EC 3.2.1.3

# Metabolic_Enzyme_13_GenBank_ID_Protein:
17648144

# Metabolic_Enzyme_13_SwissProt_ID:
MGA_HUMAN (O43451)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
MGAM

# Metabolic_Enzyme_13_Geneatlas_id:
MGAM

# Metabolic_Enzyme_13_hgnc_id:
HGNC:7043

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Cell membrane; apical cell membrane; single- pass type II membrane protein. Note=Brush border

# Metabolic_Enzyme_13_Gene_Sequence:
>5574 bp

ATGGCAAGAAAGAAGCTGAAAAAATTTACTACTTTGGAGATTGTGCTCAGTGTTCTTCT
GCTTGTGTTGT
TTATCATCAGTATTGTTCTAATTGTGCTTTTAGCCAAAGAGTCACTGA
AATCAACAGCCCCAGATCCTGG
GACAACTGGTACCCCAGATCCTGGGACAACTGGTACC
CCAGATCCTGGAACAACTGGTACCACACATGCT
AGGACAACGGGTCCCCCAGATCCTGG
AACAACTGGTACCACTCCTGTTTCTGCTGAATGTCCAGTGGTAA
ATGAATTGGAACGAA
TTAATTGCATCCCTGACCAGCCGCCAACAAAGGCCACATGTGACCAACGTGGCTG
TTGC
TGGAATCCCCAGGGAGCTGTAAGTGTTCCCTGGTGCTACTATTCCAAGAATCATAGCTAC
CATGTA
GAGGGCAACCTTGTCAACACAAATGCAGGATTCACAGCCCGGTTGAAAAATCT
GCCTTCTTCACCAGTGT
TTGGAAGCAATGTTGACAATGTTCTTCTCACAGCAGAATATC
AGACATCTAATCGTTTCCACTTTAAGTT
GACTGACCAAACCAATAACAGGTTTGAAGTG
CCCCACGAACACGTGCAGTCCTTCAGTGGAAATGCTGCT
GCTTCTTTGACCTACCAAGT
TGAAATCTCCAGACAGCCATTTAGCATCAAAGTGACCAGAAGAAGCAACA
ATCGTGTTT
TGTTTGACTCGAGCATTGGGCCCCTACTGTTTGCTGACCAGTTCTTGCAGCTCTCCACTC
G
ACTGCCTAGCACTAACGTGTATGGCCTGGGAGAGCATGTGCACCAGCAGTATCGGCAT
GATATGAATTGG
AAGACCTGGCCCATATTTAACAGAGACACAACTCCCAATGGAAACGG
AACTAATTTGTATGGTGCGCAGA
CATTCTTCTTGTGCCTTGAAGATGCTAGTGGATTGT
CCTTTGGGGTGTTTCTGATGAACAGCAATGCCAT
GGAGGTTGTCCTTCAGCCTGCGCCA
GCCATCACTTACCGCACCATTGGGGGCATTCTCGACTTCTATGTG
TTCTTGGGAAACAC
TCCAGAGCAAGTTGTTCAAGAATATCTAGAGCTCATTGGGCGGCCAGCCCTTCCCT
CCT
ACTGGGCGCTTGGATTTCACCTCAGTCGTTACGAATATGGAACCTTAGACAACATGAGGG
AAGTCGT
GGAGAGAAATCGCGCAGCACAGCTCCCTTATGATGTTCAGCATGCTGATATT
GATTATATGGATGAGAGA
AGGGACTTCACTTATGATTCAGTGGATTTTAAAGGCTTCCC
TGAATTTGTCAACGAGTTACACAATAATG
GACAGAAGCTTGTCATCATTGTGGATCCAG
CCATCTCCAACAACTCTTCCTCAAGTAAACCCTATGGCCC
ATATGACAGGGGTTCAGAT
ATGAAGATATGGGTGAATAGTTCAGATGGAGTGACTCCACTCATTGGGGAG
GTCTGGCC
TGGACAAACTGTGTTTCCTGATTATACCAATCCCAACTGTGCTGTTTGGTGGACAAAGGA
AT
TTGAGCTTTTTCACAATCAAGTAGAGTTTGATGGAATCTGGATTGATATGAATGAAG
TCTCCAACTTTGT
TGATGGTTCGGTCTCAGGATGTTCCACAAACAACCTAAATAATCCC
CCATTCACTCCCAGAATCCTGGAT
GGGTACCTGTTCTGCAAGACTCTCTGTATGGATGC
AGTGCAGCACTGGGGCAAGCAGTATGACATTCACA
ATCTGTATGGCTACTCCATGGCGG
TCGCCACAGCAGAAGCTGCCAAGACTGTGTTCCCTAATAAGAGAAG
CTTCATTCTGACC
CGTTCTACCTTTGCGGGCTCTGGCAAGTTTGCAGCACATTGGTTAGGAGACAACACT
GC
CACCTGGGATGACCTGAGATGGTCCATCCCTGGCGTGCTTGAGTTCAACCTTTTTGGCAT
CCCAATGG
TGGGTCCTGACATATGTGGCTTTGCTTTGGACACCCCTGAGGAGCTCTGTA
GGCGGTGGATGCAGTTGGG
TGCATTTTATCCGTTTTCTAGAAATCACAATGGCCAAGGC
TACAAGGACCAGGATCCTGCCTCCTTTGGA
GCTGACTCCCTGCTGTTGAATTCCTCCAG
GCACTACCTTAACATCCGCTATACTCTATTGCCCTACCTAT
ACACCCTTTTCTTCCGTG
CTCACAGCCGAGGGGACACGGTGGCCAGGCCCCTTTTGCATGAGTTCTACGA
GGACAAC
AGCACTTGGGATGTGCACCAACAGTTCTTATGGGGGCCCGGCCTCCTCATCACTCCAGTT
CTG
GATGAAGGTGCAGAGAAAGTGATGGCATATGTGCCTGATGCTGTCTGGTATGACTA
CGAGACTGGGAGCC
AAGTGAGATGGAGGAAGCAAAAAGTCGAGATGGAACTTCCTGGAG
ACAAAATTGGACTTCACCTTCGAGG
AGGCTACATCTTCCCCACACAGCAGCCAAATACA
ACCACTCTGGCCAGTCGAAAGAACCCTCTTGGTCTT
ATCATTGCCCTAGATGAGAACAA
AGAAGCAAAAGGAGAACTTTTCTGGGATGATGGGGAAACGAAGGATA
CTGTGGCCAATA
AAGTGTATCTTTTATGTGAGTTTTCTGTCACTCAAAACCGCTTGGAGGTGAATATTTC
A
CAATCAACCTACAAGGACCCCAATAATTTAGCATTTAATGAGATTAAAATTCTTGGGACG
GAGGAACCT
AGCAATGTTACAGTGAAACACAATGGTGTCCCAAGTCAGACTTCTCCTAC
AGTCACTTATGATTCTAACC
TGAAGGTTGCCATTATCACAGATATTGATCTTCTCCTGG
GAGAAGCATACACAGTGGAATGGAGCATAAA
GATAAGGGATGAAGAAAAAATAGACTGT
TACCCTGATGAGAATGGTGCTTCTGCCGAAAACTGCACTGCC
CGTGGCTGTATCTGGGA
GGCATCCAATTCTTCTGGAGTCCCTTTTTGCTATTTTGTCAACGACCTATACT
CTGTCA
GTGATGTTCAGTATAATTCCCATGGGGCCACAGCTGACATCTCCTTAAAGTCTTCCGTTT
ATGC
CAATGCCTTCCCCTCCACACCCGTGAACCCCCTTCGCCTGGATGTCACTTACCAT
AAGAATGAAATGCTG
CAGTTCAAGATTTATGATCCCAACAAGAATCGGTATGAAGTTCC
AGTCCCTCTGAACATACCCAGCATGC
CATCCAGCACCCCTGAGGGTCAACTCTATGATG
TGCTCATTAAGAAGAATCCATTTGGGATTGAAATTCG
CCGGAAGAGTACAGGCACTATA
ATTTGGGACTCTCAGCTCCTTGGCTTTACCTTCAGTGACATGTTTATC
CGCATCTCCAC
CCGCCTTCCCTCCAAGTACCTCTATGGCTTTGGGGAAACTGAGCACAGGTCCTATAGGA
GAGACTTGGAGTGGCACACTTGGGGGATGTTCTCCCGAGACCAGCCCCCAGGGTACAAGA
AGAATTCCTA
TGGTGTCCACCCCTACTACATGGGGCTGGAGGAGGACGGCAGTGCCCAT
GGAGTGCTCCTGCTGAACAGC
AATGCCATGGATGTGACGTTCCAGCCCCTGCCTGCCTT
GACATACCGCACCACAGGGGGAGTTCTGGACT
TTTATGTGTTCTTGGGGCCGACTCCAG
AGCTTGTCACCCAGCAGTACACTGAGTTGATTGGCCGGCCTGT
GATGGTACCTTACTGG
TCTTTGGGGTTCCAGCTGTGTCGCTATGGCTACCAGAATGACTCTGAGATCGCC
AGCTT
GTATGATGAGATGGTGGCTGCCCAGATCCCTTATGATGTGCAGTACTCAGACATCGACTA
CATGG
AGCGGCAGCTGGACTTCACCCTCAGCCCCAAGTTTGCTGGGTTTCCAGCTCTGA
TCAATCGCATGAAGGC
TGATGGGATGCGGGTCATCCTCATTCTGGATCCAGCCATTTCT
GGCAATGAGACACAGCCTTATCCTGCC
TTCACTCGGGGCGTGGAGGATGACGTCTTCAT
CAAATACCCAAATGATGGAGACATTGTCTGGGGAAAGG
TCTGGCCTGATTTTCCTGATG
TTGTTGTGAATGGGTCTCTAGACTGGGACAGCCAAGTGGAGCTATATCG
AGCTTATGTG
GCCTTCCCAGACTTTTTCCGTAATTCAACTGCCAAGTGGTGGAAGAGGGAAATAGAAGAA

CTATACAACAATCCACAGAATCCAGAGAGGAGCTTGAAGTTTGATGGCATGTGGATTGA
TATGAATGAAC
CATCAAGCTTCGTGAATGGGGCAGTTTCTCCAGGCTGCAGGGACGCCT
CTCTGAACCACCCTCCCTACAT
GCCACATTTGGAGTCCAGGGACAGGGGCCTGAGCAGC
AAGACCCTTTGTATGGAGAGTCAGCAGATCCTC
CCAGACGGCTCCCTGGTGCAGCACTA
CAACGTGCACAACCTGTATGGGTGGTCCCAGACCAGACCCACAT
ACGAAGCCGTGCAGG
AGGTGACGGGACAGCGAGGGGTCGTCATCACCCGCTCCACATTTCCCTCTTCTGG
CCGC
TGGGCAGGACATTGGCTGGGAGACAACACGGCCGCATGGGATCAGCTGAAGAAGTCTATC
ATTGGC
ATGATGGAGTTCAGCCTCTTCGGCATATCCTATACGGGAGCAGATATCTGTGG
GTTCTTTCAAGATGCTG
AATATGAGATGTGTGTTCGCTGGATGCAGCTGGGGGCCTTTT
ACCCCTTCTCAAGAAACCACAACACCAT
TGGGACCAGGAGACAAGACCCTGTGTCCTGG
GATGTTGCTTTTGTGAATATTTCCAGAACTGTCCTGCAG
ACCAGATACACCCTGTTGCC
ATATCTGTATACCTTGATGCATAAGGCCCACACGGAGGGCGTCACTGTTG
TGCGGCCTC
TGCTCCATGAATTTGTGTCAGACCAGGTGACATGGGACATAGACAGTCAGTTCCTGCTGG
G
CCCAGCCTTCCTGGTCAGCCCTGTCCTGGAGCGTAATGCCAGAAATGTCACTGCATAT
TTCCCTAGAGCC
CGCTGGTATGATTACTACACGGGTGTGGATATTAATGCAAGAGGAGA
GTGGAAGACCTTGCCAGCCCCTC
TTGACCACATTAATCTTCATGTCCGTGGGGGCTACA
TCCTGCCCTGGCAAGAGCCTGCACTGAACACCCA
CTTAAGCCGCCAGAAATTCATGGGC
TTCAAAATTGCCTTGGATGATGAAGGAACTGCTGGGGGCTGGCTC
TTCTGGGATGATGG
GCAAAGCATTGATACCTATGGGAAAGGACTCTATTACTTGGCCAGCTTTTCTGCCA
GCC
AGAATACGATGCAAAGCCATATAATTTTCAACAATTACATCACTGGTACAAATCCTTTGA
AACTGGG
CTACATTGAAATCTGGGGAGTGGGCAGTGTCCCCGTTACCAGTGTCAGCATC
TCTGTGAGTGGCATGGTC
ATAACACCCTCCTTCAACAATGACCCCACGACACAGGTATT
AAGCATCGATGTGACTGACAGAAACATCA
GCCTACATAATTTTACTTCATTGACGTGGA
TAAGCACTCTGTGA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
AF016833

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_13_Locus:
7q34

# Metabolic_Enzyme_13_SNPs:
rs2272330; rs2960746; rs9655651; rs2961085; rs10255702; rs2960758; rs6975672; rs7785793; rs7781962; rs7785785; rs1285938; rs1554779; rs1285943; rs2014744; rs2916189; rs2950415; rs6974784; rs1285939; rs1294353; rs1285942; rs1285940; rs1285941; rs9986889; rs1315501; rs1285963; rs2204607; rs1358305; rs1880924; rs1298582; rs3793158; rs4416750; rs7797443; rs4725564; rs2272329; rs4236462; rs6464459; rs6972387; rs10464448; rs1285964; rs2961075; rs4132774; rs4607527; rs6979075; rs2960744; rs4509233; rs6946799; rs10271514; rs6464455; rs4283959; rs4401759; rs1465093; rs7809134; rs4492290; rs11762139; rs1285965; rs6464456; rs7793854; rs4311588; rs1527308; rs2961084; rs4259331; rs6973762; rs4726487; rs10248676; rs2272327; rs10275642; rs6959526; rs11764581; rs6952930; rs12666982; rs1527304; rs2961093; rs6464460; rs6948116; rs10267188; rs7797360; rs3800992; rs2961072; rs2960747; rs6971536; rs6972399; rs1358304; rs10265585; rs4374898; rs10263152; rs10251374; rs4726489; rs2961089; rs6972071; rs10238188; rs10952514; rs2960741; rs17162645; rs4481500; rs2961071; rs10259614; rs10274953; rs10232224; rs11982668; rs10269898; rs6963697; rs4295577; rs10270832; rs2960757; rs11761379; rs4725565; rs7785237; rs1527307; rs6956284; rs12535134; rs6942712; rs2961088; rs3800993; rs17635392; rs6966500; rs6945268; rs2960753; rs10225000; rs2272332; rs12540186; rs4336523; rs6955265; rs10263497; rs7810984; rs4329195; rs2961070; rs10282125; rs4341081; rs6977302; rs10274727; rs10243909; rs10266961; rs4281037; rs7777521; rs6464457; rs10952513; rs2961079; rs10237480; rs6955801; rs10259179; rs6464458; rs4341082; rs10234559; rs11772559; rs7801101; rs3936103; rs6945098; rs10269972; rs4434539; rs7807614; rs6973212; rs13235026; rs2960745; rs2961086; rs4466313; rs10271524; rs4077884; rs11763459; rs4467860; rs10247389; rs4276595; rs11972048; rs10952515; rs10215074; rs4374899; rs10250021; rs10269815; rs13245455; rs4726488; rs7797154; rs10259247; rs12703416; rs4285406; rs10215397; rs2272333; rs4236463; rs8180874; rs4470936; rs10259861; rs10274045; rs12535693; rs11977977; rs2960749; rs11984387; rs11767883; rs12703419; rs7807635; rs4478492; rs10262878; rs3793160; rs10246711; rs10258756; rs11979847; rs10259080; rs10952512; rs6971200; rs10228658; rs11976181; rs1852508; rs10227984; rs10244346; rs12535150; rs2960748; rs13246665; rs10260661; rs3922664; rs7801560; rs10233312; rs10270252; rs4072660; rs7788669; rs4445145; rs10268987; rs12703420; rs10228285; rs10279559; rs4323398; rs2961073; rs7778384; rs10215743; rs6948269; rs12534166; rs10282365; rs3793159; rs4439034; rs2272331; rs7811738; rs6976953; rs10224348; rs6959585; rs1554778; rs1985729; rs1609100; rs17523282; rs17523275; rs12534052; rs13437780; rs3087318; rs3024261; rs10266732; rs2961087; rs3087316; rs3087313; rs3087312; rs3087321; rs2272326; rs3087320; rs3087317; rs2961078; rs2960743; rs2960736; rs2961074; rs3087319; rs2960742; rs34857144; rs35653081; rs28514687; rs10226939; rs34760774; rs12703415; rs5888024; rs35669493; rs3793155; rs35920360; rs34459807; rs1285966; rs10237141; rs35788986; rs34895109; rs11983493; rs10247082; rs12703421; rs10244325; rs28423084; rs4281038; rs12703417; rs10273420; rs35749361; rs10248818; rs11520861; rs28510141; rs10241636; rs10282275; rs35847864; rs7797111; rs10237351; rs10250665; rs35268349; rs11461388; rs35480595; rs13309020; rs12333515; rs34430579; rs6979151; rs7812190; rs2960756; rs1527306; rs10667629; rs2961068; rs7458999; rs10258491; rs34192955; rs2961091; rs2961090; rs2961050; rs2960738; rs35988825; rs28537610; rs6959057; rs34813545; rs34977568; rs35537649; rs34188746; rs4305809; rs28469296; rs2961080; rs35712953; rs10215393; rs5888027; rs35959513; rs28437665; rs2960752; rs11298938; rs10278406; rs12534614; rs13247647; rs5018142; rs10256983; rs35461005; rs6975959; rs28716240; rs4577878; rs34723275; rs13244181; rs7779914; rs28581545; rs10276356; rs11387547; rs11380053; rs34657431; rs10215476; rs7811050; rs4518576; rs4507684; rs28412172; rs35949770; rs10238608; rs4072659; rs10580224; rs4395805; rs13309153; rs35944134; rs34615965; rs13221059; rs4559156; rs28645759; rs11974543; rs13311070; rs28379279; rs28674598; rs34336582; rs11771350; rs35891390; rs34641123; rs5888030; rs35278052; rs5018141; rs12154542; rs36061384; rs10259742; rs10215116; rs28497852; rs13310650; rs6957100; rs2960739; rs7794785; rs6958744; rs13309184; rs35142877; rs34914843; rs35038034; rs35345914; rs10259159; rs10244836; rs2960740; rs2961051; rs34541464; rs10243556; rs28628756; rs10248179; rs13308609; rs1159908; rs10260094; rs35054393; rs13310356; rs3087323; rs35315198; rs2961077; rs6943118; rs4276597; rs4236465; rs10231300; rs34951844; rs7800808; rs35767682; rs12531274; rs4725566; rs2960750; rs34025802; rs2960754; rs6950286; rs5888026; rs5888025; rs34471297; rs28477143; rs4344010; rs10250427; rs7777496; rs10273141; rs35884991; rs3923516; rs28570409; rs35116200; rs34441915; rs4410826; rs10249175; rs11560310; rs13310467; rs35584918; rs28712440; rs2961082; rs13310343; rs2960759; rs34189651; rs10267379; rs7781119; rs10280322; rs10276588; rs35219643; rs12155113; rs10693852; rs35289418; rs28586906; rs2950416; rs36052135; rs34100990; rs7357303; rs10282020; rs35169560; rs35184064; rs3087322; rs7458091; rs6959679; rs6150373; rs35295955; rs7785722; rs28566864; rs2960755; rs4236464; rs34011006; rs2961083; rs35030661; rs4310117; rs34912666; rs4725567; rs13309170; rs2960751; rs28469053; rs11380054; rs35627220; rs2272328; rs7793931; rs1918300; rs13310649; rs34810980; rs34827622; rs34524738; rs4397311; rs13310468; rs35280330; rs10257488; rs4072658; rs28446896; rs2960737; rs34828733; rs2961076; rs13310136; rs10262981; rs4276596; rs10258954; rs10271669; rs12155112; rs11289169; rs10667628; rs34618129; rs12334002; rs35425766; rs9768807; rs2068065; rs10601773; rs2961069; rs11452654; rs35626773; rs13310352; rs10234045; rs941254; rs1527305; rs13234464; rs34993763; rs34385353; rs35513186; rs34254997; rs28476688; rs2961092; rs13310384; rs7785703; rs28559920; rs5888028; rs11770427; rs10710111; rs10229158; rs34917609; rs35381053; rs35957939; rs10225228; rs10234068; rs10246387; rs10273892; rs10952516; rs12703414; rs1294351; rs1298999; rs4288283; rs4324856; rs4407790; rs4428591; rs4593441; rs4632974; rs4725568; rs4726484; rs6947481; rs6951223; rs6951410

# Metabolic_Enzyme_13_General_References:
9446624; 3143729; 3121301

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
8825

# Metabolic_Enzyme_14_Name:
Lysosomal protective protein precursor

# Metabolic_Enzyme_14_Synonyms:
Cathepsin A; Carboxypeptidase C; Protective protein for beta-galactosidase[Contains: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain]

# Metabolic_Enzyme_14_Gene_Name:
CTSA

# Metabolic_Enzyme_14_Protein_Sequence:
>Lysosomal protective protein precursor
MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSK
HLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLI
ANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYA
GIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHC
CSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQD
LGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWD
MCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKME
VQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY


# Metabolic_Enzyme_14_Number_of_Residues:
480

# Metabolic_Enzyme_14_Molecular_Weight:
54467

# Metabolic_Enzyme_14_Theoretical_pI:
6.59

# Metabolic_Enzyme_14_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  exopeptidase activity
Function:  carboxypeptidase activity
Function:  serine carboxypeptidase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Amino acid transport and metabolism

# Metabolic_Enzyme_14_Specific_Function:
Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins

# Metabolic_Enzyme_14_Pathway:
Not Available

# Metabolic_Enzyme_14_Reaction:
Release of a C-terminal amino acid with broad specificity

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00450:Peptidase_S10

# Metabolic_Enzyme_14_Signals:
1-28

# Metabolic_Enzyme_14_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 3.4.16.5

# Metabolic_Enzyme_14_GenBank_ID_Protein:
190283

# Metabolic_Enzyme_14_SwissProt_ID:
PPGB_HUMAN (P10619)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
CTSA

# Metabolic_Enzyme_14_Geneatlas_id:
CTSA

# Metabolic_Enzyme_14_hgnc_id:
HGNC:9251

# Metabolic_Enzyme_14_PDB_ID:
1IVY

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_14_Gene_Sequence:
>1443 bp
ATGATCCGAGCCGCGCCGCCGCCGCTGTTCCTGCTGCTGCTGCTGCTGCTGCTGCTAGTG
TCCTGGGCGTCCCGAGGCGAGGCAGCCCCCGACCAGGACGAGATCCAGCGCCTCCCCGGG
CTGGCCAAGCAGCCGTCTTTCCGCCAGTACTCCGGCTACCTCAAAAGCTCCGGCTCCAAG
CACCTCCACTACTGGTTTGTGGAGTCCCAGAAGGATCCCGAGAACAGCCCTGTGGTGCTT
TGGCTCAATGGGGGTCCCGGCTGCAGCTCACTAGATGGGCTCCTCACAGAGCATGGCCCC
TTCCTGGTCCAGCCAGATGGTGTCACCCTGGAGTACAACCCCTATTCTTGGAATCTGATT
GCCAATGTGTTATACCTGGAGTCCCCAGCTGGGGTGGGCTTCTCCTACTCCGATGACAAG
TTTTATGCAACTAATGACACTGAGGTCGCCCAGAGCAATTTTGAGGCCCTTCAAGATTTC
TTCCGCCTCTTTCCGGAGTACAAGAACAACAAACTTTTCCTGACCGGGGAGAGCTATGCT
GGCATCTACATCCCCACCCTGGCCGTGCTGGTCATGCAGGATCCCAGCATGAACCTTCAG
GGGCTGGCTGTGGGCAATGGACTCTCCTCCTATGAGCAGAATGACAACTCCCTGGTCTAC
TTTGCCTACTACCATGGCCTTCTGGGGAACAGGCTTTGGTCTTCTCTCCAGACCCACTGC
TGCTCTCAAAACAAGTGTAACTTCTATGACAACAAAGACCTGGAATGCGTGACCAATCTT
CAGGAAGTGGCCCGCATCGTGGGCAACTCTGGCCTCAACATCTACAATCTCTATGCCCCG
TGTGCTGGAGGGGTGCCCAGCCATTTTAGGTATGAGAAGGACACTGTTGTGGTCCAGGAT
TTGGGCAACATCTTCACTCGCCTGCCACTCAAGCGGATGTGGCATCAGGCACTGCTGCGC
TCAGGGGATAAAGTGCGCATGGACCCCCCCTGCACCAACACAACAGCTGCTTCCACCTAC
CTCAACAACCCGTACGTGCGGAAGGCCCTCAACATCCCGGAGCAGCTGCCACAATGGGAC
ATGTGCAACTTTCTGGTAAACTTACAGTACCGCCGTCTCTACCGAAGCATGAACTCCCAG
TATCTGAAGCTGCTTAGCTCACAGAAATACCAGATCCTATTATATAATGGAGATGTAGAC
ATGGCCTGCAATTTCATGGGGGATGAGTGGTTTGTGGATTCCCTCAACCAGAAGATGGAG
GTGCAGCGCCGGCCCTGGTTAGTGAAGTACGGGGACAGCGGGGAGCAGATTGCCGGCTTC
GTGAAGGAGTTCTCCCACATCGCCTTTCTCACGATCAAGGGCGCCGGCCACATGGTTCCC
ACCGACAAGCCCCTCGCTGCCTTCACCATGTTCTCCCGCTTCCTGAACAAGCAGCCATAC
TGA

# Metabolic_Enzyme_14_GenBank_ID_Gene:
M22960

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_14_Locus:
20q13.1

# Metabolic_Enzyme_14_SNPs:
rs25649; rs4608591; rs7270170; rs11569665; rs4810476; rs742034; rs11569663; rs6104390; rs6094225; rs11569662; rs11569664; rs11569667; rs2075961; rs2075962; rs2075963; rs11538053; rs11484230; rs6094226; rs5841612; rs33947058; rs34656072; rs3215446; rs6130962; rs34800818; rs34590242; rs6130963; rs11468785; rs6094227; rs11698406; rs6124756; rs34300421; rs11480920; rs396980; rs11569666; rs35404688; rs5841610; rs5841611; rs35814654; rs11482387; rs1056929; rs11086984; rs11086985; rs11569644; rs11569645; rs11569646; rs11569647; rs11569649; rs11569651; rs11569652; rs11569661; rs11569674; rs11569675; rs12481109; rs1736493; rs1804161; rs1804212; rs1804213; rs2077056; rs2664568; rs2664590; rs2868362; rs34017227; rs34942730; rs35165640; rs35342327; rs35972756; rs3746500; rs3817731; rs3827040; rs4812974; rs4942; rs553359; rs6017711; rs6032575; rs6032577; rs6032580; rs6065903; rs6065904; rs6073942; rs6073943; rs6073945; rs6073946; rs6073947; rs6073951; rs6073952; rs6094224; rs6104386; rs6104388; rs6104389; rs6104393; rs7268221; rs742035

# Metabolic_Enzyme_14_General_References:
3136930; 11780052; 1694176; 12665801; 1907282; 8591035; 1756715; 8514852

# Metabolic_Enzyme_14_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7045

# Macromolecular_Interacting_Partner_1_Name:
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

# Macromolecular_Interacting_Partner_1_Synonyms:
O-GlcNAc transferase p110 subunit

# Macromolecular_Interacting_Partner_1_Gene_Name:
OGT

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>UDPNacetylglucosaminepeptide Nacetylglucosaminyltransferase 110 kDa subunit
MASSVGNVADSTEPTKRMLSFQGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLL
LSSIHFQCRR
LDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLK
PDFIDGYINLAAALVAAGDME
GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKA
CYLKAIETQPNFAVAWSNLGCVFNAQGEIWLA
IHHFEKAVTLDPNFLDAYINLGNVLKE
ARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAID
TYRRAIELQPHFPDAY
CNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLY
RKALE
VFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGAL
QCYTR
AIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQ
IVCDWTDYDERMKKLV
SIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLD
KINVLHKPPYEHPKDLKLSDGRLRVGY
VSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYA
LSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQ
DGIHILVNMNGYTKGARNELF
ALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEKLAYMP
HTFFIGDHAN
MFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSNT

ALNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIV
TTRSQYGLPED
AIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQ
YAQNMGLPQNRIIFSPVAPKEE
HVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMP
GETLASRVAASQLTCLGCLELIAKNRQEYEDIA
VKLGTDLEYLKKVRGKVWKQRISSPL
FNTKQYTMELERLYLQMWEHYAAGNKPDHMIKPVEVTESA

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
1046

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
116926

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.68

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00515:TPR_1

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
2266994

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
OGT1_HUMAN (O15294)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
OGT

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
OGT

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:8127

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cytoplasm (Potential). Nucleus (Potential)

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>2763 bp

ATGCTGCAGGGTCACTTTTGGCTGGTCAGAGAAGGAATAATGATATCACCTTCTTCCCC
CCCTCCCCCCA
ATCTTTTTTTTTTCCCTTTACAAATTTTCCCCTTTCCCTTTACCTCCT
TTCCCTCCCATCTTCTTTCATT
AACCCCTCCTAAGGCATGTTATTTGAAAGCAATTGAG
ACGCAACCGAACTTTGCAGTAGCTTGGAGTAAT
CTTGGCTGTGTTTTCAATGCACAAGG
GGAAATTTGGCTTGCAATTCATCACTTTGAAAAGGCTGTCACCC
TTGACCCAAACTTTC
TGGATGCTTATATCAATTTAGGAAATGTCTTGAAAGAGGCACGCATTTTTGACAG
AGCT
GTGGCAGCTTATCTTCGTGCCCTAAGTTTGAGTCCAAATCACGCAGTGGTGCACGGCAAC
CTGGCT
TGTGTATACTATGAGCAAGGCCTGATAGATCTGGCAATAGACACCTACAGGCG
GGCTATCGAACTACAAC
CACATTTCCCTGATGCTTACTGCAACCTAGCCAATGCTCTCA
AAGAGAAGGGCAGTGTTGCTGAAGCAGA
AGATTGTTATAATACAGCTCTCCGTCTGTGT
CCCACCCATGCAGACTCTCTGAATAACCTAGCCAATATC
AAACGAGAACAGGGAAACAT
TGAAGAGGCAGTTCGCTTGTATCGTAAAGCATTAGAAGTCTTCCCAGAGT
TTGCTGCTG
CCCATTCAAATTTAGCAAGTGTACTGCAGCAGCAGGGAAAACTGCAGGAAGCTCTGATGC
A
TTATAAGGAGGCTATTCGAATCAGTCCTACCTTTGCTGATGCCTACTCTAATATGGGA
AACACTCTAAAG
GAGATGCAGGATGTTCAGGGAGCCTTGCAGTGTTATACGCGTGCCAT
CCAAATTAATCCTGCATTTGCAG
ATGCACATAGCAATCTGGCTTCCATTCATAAGGATT
CAGGGAATATTCCAGAAGCCATAGCTTCTTACCG
CACGGCTCTGAAACTTAAGCCTGAT
TTTCCTGATGCTTATTGTAACTTGGCTCATTGCCTGCAGATTGTC
TGTGATTGGACAGA
CTATGATGAGCGAATGAAGAAGTTGGTCAGTATTGTGGCTGACCAGTTAGAGAAGA
ATA
GGTTGCCTTCTGTGCATCCTCATCATAGTATGCTATATCCTCTTTCTCATGGCTTCAGGA
AGGCTAT
TGCTGAGAGGCACGGCAACCTGTGCTTAGATAAGATTAATGTTCTTCATAAA
CCACCATATGAACATCCA
AAAGACTTGAAGCTCAGTGATGGTCGGCTGCGTGTAGGATA
TGTGAGTTCCGACTTTGGGAATCATCCTA
CTTCTCACCTTATGCAGTCTATTCCAGGCA
TGCACAATCCTGATAAATTTGAGGTGTTCTGTTATGCCCT
GAGCCCAGACGATGGCACA
AACTTCCGAGTGAAGGTGATGGCAGAAGCCAATCATTTCATTGATCTTTCT
CAGATTCC
ATGCAATGGAAAAGCAGCTGATCGCATCCATCAGGATGGAATTCATATCCTTGTAAATAT
GA
ATGGCTATACTAAGGGCGCTCGAAATGAGCTTTTTGCTCTCAGGCCAGCTCCTATTC
AGGCAATGTGGCT
GGGATACCCTGGGACGAGTGGTGCGCTTTTCATGGATTATATTATC
ACTGATCAGGAAACTTCGCCAGCT
GAAGTTGCTGAGCAGTATTCCGAGAAATTGGCTTA
TATGCCCCACACTTTTTTTATTGGTGATCATGCTA
ATATGTTCCCTCACCTGAAGAAAA
AAGCAGTCATCGATTTTAAGTCCAATGGGCACATTTATGACAATCG
GATAGTTCTGAAT
GGCATCGACCTCAAAGCATTTCTTGATAGTCTACCAGATGTGAAAATTGTCAAGATG
AA
GTGTCCTGATGGAGGAGACAATGCAGATAGCAGTAACACAGCTCTTAATATGCCTGTTAT
TCCTATGA
ATACTATTGCAGAAGCAGTTATTGAAATGATTAACCGAGGACAGATTCAAA
TAACAATTAATGGATTCAG
TATTAGCAATGGACTGGCAACTACTCAGATCAACAATAAG
GCTGCAACTGGAGAGGAGGTTCCCCGTACC
ATTATTGTAACCACCCGTTCTCAGTACGG
GTTACCAGAAGATGCCATCGTATACTGTAACTTTAATCAGT
TGTATAAAATTGACCCTT
CTACTTTGCAGATGTGGGCAAACATTCTGAAGCGTGTTCCCAATAGTGTACT
CTGGCTG
TTGCGTTTTCCAGCAGTAGGAGAACCTAATATTCAACAGTATGCACAAAACATGGGCCTG
CCC
CAGAACCGTATCATTTTTTCACCTGTTGCTCCTAAAGAGGAACACGTCAGGAGAGG
CCAGCTGGCTGATG
TCTGCTTGGACACTCCACTCTGTAATGGGCACACCACAGGGATGG
ATGTCCTCTGGGCAGGGACCCCCAT
GGTGACTATGCCAGGAGAGACTCTTGCTTCTCGA
GTTGCAGCATCCCAGCTCACTTGCTTAGGTTGTCTT
GAGCTTATTGCTAAAAACAGACA
AGAATATGAAGACATAGCTGTGAAGCTGGGAACTGATCTAGAATACC
TGAAGAAAGTTC
GTGGCAAAGTCTGGAAGCAAAGAATATCTAGCCCTCTGTTCAACACCAAACAATACAC
A
ATGGAACTAGAGCGGCTCTATCTACAGATGTGGGAGCATTATGCAGCTGGCAACAAACCT
GACCACATG
ATTAAGCCTGTTGAAGTCACTGAGTCAGCATAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
U77413

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_1_Locus:
Xq13

# Macromolecular_Interacting_Partner_1_SNPs:
rs34739713; rs34350994; rs6525488; rs5936630; rs6525489; rs3736670; rs11796215; rs12010797; rs11094204; rs4844296; rs4844297; rs2878161; rs12010194; rs12013063; rs12008091; rs1804763; rs35370336; rs11345203; rs5936631; rs5937092; rs6624558; rs34966587; rs7883541; rs34846338; rs34416880; rs41331244; rs35011801; rs12556218; rs12857729; rs34642674; rs5937093; rs11438332; rs35384418; rs35825458; rs5902686; rs34412554; rs35924897; rs720617; rs12841963; rs6624557; rs35436054; rs35779562; rs12834194; rs12835170; rs11414907; rs12833774; rs35539640; rs35816752; rs12008611; rs10704468; rs35156267; rs3842473; rs35996733; rs5902687; rs1063695; rs2272780; rs6625800; rs34723007; rs34545535; rs35847609; rs34214130; rs41505544; rs12834037; rs12838768; rs34223217; rs35720004; rs34951066; rs4844295; rs11319380; rs34127823; rs35135091; rs35949079; rs12012140; rs12834159; rs13440475; rs5937091

# Macromolecular_Interacting_Partner_1_General_References:
9083068; 11773972; 12670868

# Macromolecular_Interacting_Partner_1_References:
17122093

# Macromolecular_Interacting_Partner_2_ID:
7547

# Macromolecular_Interacting_Partner_2_Name:
Somatotropin precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Growth hormone; GH; GH-N; Pituitary growth hormone; Growth hormone 1

# Macromolecular_Interacting_Partner_2_Gene_Name:
GH1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Somatotropin precursor
MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEA
YIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLR
SVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDD
ALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
217

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
24848

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.09

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_2_Signals:
1-26

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
31905

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
SOMA_HUMAN (P01241)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
GH1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
GH1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:4261

# Macromolecular_Interacting_Partner_2_PDB_ID:
1HWG

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>654 bp
ATGGCTACAGGCTCCCGGACGTCCCTGCTCCTGGCTTTTGGCCTGCTCTGCCTGCCCTGG
CTTCAAGAGGGCAGTGCCTTCCCAACCATTCCCTTATCCAGGCCTTTTGACAACGCTATG
CTCCGCGCCCATCGTCTGCACCAGCTGGCCTTTGACACCTACCAGGAGTTTGAAGAAGCC
TATATCCCAAAGGAACAGAAGTATTCATTCCTGCAGAACCCCCAGACCTCCCTCTGTTTC
TCAGAGTCTATTCCGACACCCTCCAACAGGGAGGAAACACAACAGAAATCCAACCTAGAG
CTGCTCCGCATCTCCCTGCTGCTCATCCAGTCGTGGCTGGAGCCCGTGCAGTTCCTCAGG
AGTGTCTTCGCCAACAGCCTGGTGTACGGCGCCTCTGACAGCAACGTCTATGACCTCCTA
AAGGACCTAGAGGAAGGCATCCAAACGCTGATGGGGAGGCTGGAAGATGGCAGCCCCCGG
ACTGGGCAGATCTTCAAGCAGACCTACAGCAAGTTCGACACAAACTCACACAACGATGAC
GCACTACTCAAGAACTACGGGCTGCTCTACTGCTTCAGGAAGGACATGGACAAGGTCGAG
ACATTCCTGCGCATCGTGCAGTGCCGCTCTGTGGAGGGCAGCTGTGGCTTCTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00519

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_2_Locus:
17q24.2

# Macromolecular_Interacting_Partner_2_SNPs:
rs2001345; rs5388; rs6175; rs6173; rs6172; rs2665802; rs3744287; rs2001344; rs3020619; rs2005172; rs695; rs2854224; rs2854184; rs11568828; rs2011732; rs1974435; rs1811081; rs6171; rs2005171; rs2005170; rs7219235; rs2727338; rs6174; rs4080075; rs4080076; rs41295255; rs41295253; rs4080078; rs41295041; rs41295043; rs9282699; rs41295039; rs41295033; rs5821407; rs5821408; rs41295029; rs3833113; rs41295249; rs41295245; rs5821409; rs9282698; rs41295251; rs41295035; rs41295037; rs41295031; rs41295247; rs4341800; rs41299067; rs6146116; rs28485730; rs41295013; rs11568827; rs41295009; rs41295017; rs3760240; rs12945660; rs41295015; rs41299065; rs11079515; rs11657170; rs12946669; rs2070680; rs2532114; rs2532115; rs2665846; rs3180510; rs7209608

# Macromolecular_Interacting_Partner_2_General_References:
386281; 377496; 6269091; 7169009; 2744760; 10931946; 3912261; 5810834; 5144027; 4675454; 5279046; 5279528; 7462247; 7356479; 7028740; 10393484; 3447173; 1549776; 7984244; 8943276; 8552145; 9276733; 10391209; 11502836; 12655557

# Macromolecular_Interacting_Partner_2_References:
17043386; 17047388; 17114888

# Macromolecular_Interacting_Partner_3_ID:
7193

# Macromolecular_Interacting_Partner_3_Name:
Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide

# Macromolecular_Interacting_Partner_3_Synonyms:
GRPP; Oxyntomodulin; OXY; OXM; Glucagon; Glucagon-like peptide 1; GLP-1; Glucagon-like peptide 1(7-37; GLP-1(7-37; Glucagon-like peptide 1(7-36; GLP-1(7-36; Glucagon-like peptide 2; GLP-2]

# Macromolecular_Interacting_Partner_3_Gene_Name:
GCG

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Glucagon precursor Contains: Glicentin; Glicentinrelated polypeptide
MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTS
DYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFI
AWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMNTILDNLAARDFINWLIQTKITDRK


# Macromolecular_Interacting_Partner_3_Number_of_Residues:
180

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
20909

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.14

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00123:Hormone_2

# Macromolecular_Interacting_Partner_3_Signals:
1-20

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
183270

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
GLUC_HUMAN (P01275)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
GCG

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
GCG

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:4191

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>543 bp
ATGAAAAGCATTTACTTTGTGGCTGGGTTATTTGTAATGCTGGTACAAGGCAGCTGGCAA
CGTTCCCTTCAAGACACAGAGGAGAAATCCAGATCATTCTCAGCTTCCCAGGCAGACCCA
CTCAGTGATCCTGATCAGATGAACGAGGACAAGCGCCATTCACAGGGCACATTCACCAGT
GACTACAGCAAGTATCTGGACTCCAGGCGTGCCCAAGATTTTGTGCAGTGGTTGATGAAT
ACCAAGAGGAACAGGAATAACATTGCCAAACGTCACGATGAATTTGAGAGACATGCTGAA
GGGACCTTTACCAGTGATGTAAGTTCTTATTTGGAAGGCCAAGCTGCCAAGGAATTCATT
GCTTGGCTGGTGAAAGGCCGAGGAAGGCGAGATTTCCCAGAAGAGGTCGCCATTGTTGAA
GAACTTGGCCGCAGACATGCTGATGGTTCTTTCTCTGATGAGATGAACACCATTCTTGAT
AATCTTGCCGCCAGGGACTTTATAAACTGGTTGATTCAGACCAAAATCACTGACAGGAAA
TAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
J04040

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_3_Locus:
2q36-q37

# Macromolecular_Interacting_Partner_3_SNPs:
rs5645; rs4664448; rs6732914; rs4664449; rs10490424; rs10164435; rs11897425; rs7581952; rs7569992; rs7559086; rs5649; rs4664447; rs5653; rs6727317; rs13306377; rs5647; rs5654; rs13306376; rs1990761; rs6717659; rs13001107; rs16846320; rs13416088; rs35424779; rs6717263; rs3811540; rs6717609; rs35328019; rs5650; rs11552334; rs35920035; rs11552338; rs1042405; rs11552330; rs11552335; rs34074912; rs11552339; rs17711059; rs11552332; rs16846334; rs11552331; rs11552336; rs35185096; rs35902561; rs35301560; rs10557377; rs10603613; rs5648; rs34801095; rs10671204; rs33949193; rs5652; rs5646; rs11378120; rs7569999; rs34405490; rs5651; rs11898004; rs35323923; rs13429709; rs10696486; rs34204135; rs35205044; rs3811539; rs7590067; rs11692314; rs17762054; rs41368446; rs34932341; rs10170813; rs10189636; rs11888030; rs13010545; rs13028221; rs2111487; rs2193494; rs2216338; rs2389680; rs2389681; rs3761656; rs4664450; rs6704722; rs6733736; rs7599142

# Macromolecular_Interacting_Partner_3_General_References:
2901414; 3725587; 6877358; 2753890; 8482423; 14557443; 14632334; 9287128; 12651102; 12554744; 12626323; 10605628; 9667960; 11943215; 12627948

# Macromolecular_Interacting_Partner_3_References:
17055120; 17064063; 17073841; 17090794

# Macromolecular_Interacting_Partner_4_ID:
7549

# Macromolecular_Interacting_Partner_4_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
INS

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_4_Signals:
1-24

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
INS

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_4_Locus:
11p15.5

# Macromolecular_Interacting_Partner_4_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_4_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_4_References:
17027360; 17027570; 17027571; 17028432

# Macromolecular_Interacting_Partner_5_ID:
7551

# Macromolecular_Interacting_Partner_5_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_5_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_5_Locus:
6p21.3

# Macromolecular_Interacting_Partner_5_SNPs:
Not Available

# Macromolecular_Interacting_Partner_5_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_5_References:
17080243

# Macromolecular_Interacting_Partner_6_ID:
7595

# Macromolecular_Interacting_Partner_6_Name:
78 kDa glucose-regulated protein precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
GRP 78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP; Endoplasmic reticulum lumenal Ca(2+-binding protein grp78

# Macromolecular_Interacting_Partner_6_Gene_Name:
HSPA5

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>78 kDa glucoseregulated protein precursor
MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNR
ITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVV
EKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQ
RQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNG
VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALS
SQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIV
LVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVC
PLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLG
TFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIER
MVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEE
KIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
654

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
72334

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
4.80

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Macromolecular_Interacting_Partner_6_Specific_Function:
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00012:HSP70

# Macromolecular_Interacting_Partner_6_Signals:
1-18

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
386758

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
GRP78_HUMAN (P11021)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
HSPA5

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
HSPA5

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:5238

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1962 bp
ATGAAGCTCTCCCTGGTGGCCGCGATGCTGCTGCTGCTCAGCGCGGCGCGGGCCGAGGAG
GAGGACAAGAAGGAGGACGTGGGCACGGTGGTCGGCATCGACTTGGGGACCACCTACTCC
TGCGTCGGCGTGTTCAAGAACGGCCGCGTGGAGATCATCGCCAACGATCAGGGCAACCGC
ATCACGCCGTCCTATGTCGCCTTCACTCCTGAAGGGGAACGTCTGATTGGCGATGCCGCC
AAGAACCAGCTCACCTCCAACCCCGAGAACACGGTCTTTGACGCCAAGCGGCTCATCGGC
CGCACGTGGAATGACCCGTCTGTGCAGCAGGACATCAAGTTCTTGCCGTTCAAGGTGGTT
GAAAAGAAAACTAAACCATACATTCAAGTTGATATTGGAGGTGGGCAAACAAAGACATTT
GCTCCTGAAGAAATTTCTGCCATGGTTCTCACTAAAATGAAAGAAACCGCTGAGGCTTAT
TTGGGAAAGAAGGTTACCCATGCAGTTGTTACTGTACCAGCCTATTTTAATGATGCCCAA
CGCCAAGCAACCAAAGACGCTGGAACTATTGCTGGCCTAAATGTTATGAGGATCATCAAC
GAGCCTACGGCAGCTGCTATTGCTTATGGCCTGGATAAGAGGGAGGGGGAGAAGAACATC
CTGGTGTTTGACCTGGGTGGCGGAACCTTCGATGTGTCTCTTCTCACCATTGACAATGGT
GTCTTCGAAGTTGTGGCCACTAATGGAGATACTCATCTGGGTGGAGAAGACTTTGACCAG
CGTGTCATGGAACACTTCATCAAACTGTACAAAAAGAAGACGGGCAAAGATGTCAGGAAG
GACAATAGAGCTGTGCAGAAACTCCGGCGCGAGGTAGAAAAGGCCAAGGCCCTGTCTTCT
CAGCATCAAGCAAGAATTGAAATTGAGTCCTTCTATGAAGGAGAAGACTTTTCTGAGACC
CTGACTCGGGCCAAATTTGAAGAGCTCAACATGGATCTGTTCCGGTCTACTATGAAGCCC
GTCCAGAAAGTGTTGGAAGATTCTGATTTGAAGAAGTCTGATATTGATGAAATTGTTCTT
GTTGGTGGCTCGACTCGAATTCCAAAGATTCAGCAACTGGTTAAAGAGTTCTTCAATGGC
AAGGAACCATCCCGTGGCATAAACCCAGATGAAGCTGTAGCGTATGGTGCTGCTGTCCAG
GCTGGTGTGCTCTCTGGTGATCAAGATACAGGTGACCTGGTACTGCTTCATGTATGTCCC
CTTACACTTGGTATTGAAACTGTAGGAGGTGTCATGACCAAACTGATTCCAAGTAATACA
GTGGTGCCTACCAAGAACTCTCAGATCTTTTCTACAGCTTCTGATAATCAACCAACTGTT
ACAATCAAGGTCTATGAAGGTGAAAGACCCCTGACAAAAGACAATCATCTTCTGGGTACA
TTTGATCTGACTGGAATTCCTCCTGCTCCTCGTGGGGTCCCACAGATTGAAGTCACCTTT
GAGATAGATGTGAATGGTATTCTTCGAGTGACAGCTGAAGACAAGGGTACAGGGAACAAA
AATAAGATCACAATCACCAATGACCAGAATCGCCTGACACCTGAAGAAATCGAAAGGATG
GTTAATGATGCTGAGAAGTTTGCTGAGGAAGACAAAAAGCTGAAGGAGCGCATTGATACT
AGAAATGAGTTGGAAAGCTATGCCTATTCTCTAAAGAATCAGATTGGAGATAAAGAAAAG
CTGGGAGGTAAACTTTCCTCTGAAGATAAGGAGACCATGGAAAAAGCTGTAGAAGAAAAG
ATTGAATGGCTGGAAAGCCACCAAGATGCTGACATTGAAGACTTCAAAGCTAAGAAGAAG
GAACTGGAAGAAATTGTTCAACCAATTATCAGCAAACTCTATGGAAGTGCAGGCCCTCCC
CCAACTGGTGAAGAGGATACAGCAGAAAAAGATGAGTTGTAG

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
M19645

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_6_Locus:
9q33-q34.1

# Macromolecular_Interacting_Partner_6_SNPs:
rs35866338; rs12009; rs16927997; rs7922; rs7871419; rs35189333; rs35875709; rs1140763; rs430397; rs10125922; rs10986663; rs10986664; rs17253433; rs589306; rs35644223; rs34456173; rs35038898; rs17840762; rs391957; rs35877190; rs17840761; rs35650380; rs34871686; rs11542739; rs35356639; rs11542738; rs3189684; rs11542736; rs387491; rs35228219; rs34358468; rs35757312; rs11542737; rs34295340; rs35130081; rs34899577; rs8759; rs35204075; rs12352030; rs424676; rs34129695; rs35290112; rs11432886; rs35245888; rs35855725; rs35818114; rs34874380; rs34786778; rs34798155; rs11355458; rs10713635; rs7468946; rs3216733; rs35938784; rs34269398; rs13285091; rs5900647; rs34995001; rs10986665; rs36105914; rs10986660; rs12003827; rs12347750; rs15233; rs418496; rs599063; rs7864398; rs7869876; rs938729

# Macromolecular_Interacting_Partner_6_General_References:
2840249; 1480470; 9150946; 2294010; 9150948

# Macromolecular_Interacting_Partner_6_References:
17132139; 17137721; 17145889

# Macromolecular_Interacting_Partner_7_ID:
7596

# Macromolecular_Interacting_Partner_7_Name:
Solute carrier family 2, facilitated glucose transporter member 1

# Macromolecular_Interacting_Partner_7_Synonyms:
Glucose transporter type 1, erythrocyte/brain; HepG2 glucose transporter

# Macromolecular_Interacting_Partner_7_Gene_Name:
SLC2A1

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Solute carrier family 2, facilitated glucose transporter member 1
MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTT
LTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFE
MLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIM
GNKDLWPLLLSIIFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTHD
LQEMKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEK
AGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQ
LPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGM
CFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPE
ELFHPLGADSQV

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
492

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
54085

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
8.91

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  carrier activity
Function:  electrochemical potential-driven transporter activity
Function:  porter activity
Function:  sugar porter activity
Function:  transporter activity
Function:  carbohydrate transporter activity
Function:  sugar transporter activity
Function:  monosaccharide transporter activity
Function:  hexose transporter activity
Function:  glucose transporter activity
 ||
>>>
Process:  carbohydrate transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_7_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_7_Specific_Function:
Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00083:Sugar_tr

# Macromolecular_Interacting_Partner_7_Signals:
1-23

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
183303

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
GTR1_HUMAN (P11166)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
SLC2A1

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
SLC2A1

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:11005

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Cell membrane; multi-pass membrane protein. Melanosome. Note=Localizes primarily at the cell surface (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1479 bp
ATGGAGCCCAGCAGCAAGAAGCTGACGGGTCGCCTCATGCTGGCTGTGGGAGGAGCAGTG
CTTGGCTCCCTGCAGTTTGGCTACAACACTGGAGTCATCAATGCCCCCCAGAAGGTGATC
GAGGAGTTCTACAACCAGACATGGGTCCACCGCTATGGGGAGAGCATCCTGCCCACCACG
CTCACCACGCTCTGGTCCCTCTCAGTGGCCATCTTTTCTGTTGGGGGCATGATTGGCTCC
TTCTCTGTGGGCCTTTTCGTTAACCGCTTTGGCCGGCGGAATTCAATGCTGATGATGAAC
CTGCTGGCCTTCGTGTCCGCCGTGCTCATGGGCTTCTCGAAACTGGGCAAGTCCTTTGAG
ATGCTGATCCTGGGCCGCTTCATCATCGGTGTGTACTGCGGCCTGACCACAGGCTTCGTG
CCCATGTATGTGGGTGAAGTGTCACCCACAGCCTTTCGTGGGGCCCTGGGCACCCTGCAC
CAGCTGGGCATCGTCGTCGGCATCCTCATCGCCCAGGTGTTCGGCCTGGACTCCATCATG
GGCAACAAGGACCTGTGGCCCCTGCTGCTGAGCATCATCTTCATCCCGGCCCTGCTGCAG
TGCATCGTGCTGCCCTTCTGCCCCGAGAGTCCCCGCTTCCTGCTCATCAACCGCAACGAG
GAGAACCGGGCCAAGAGTGTGCTAAAGAAGCTGCGCGGGACAGCTGACGTGACCCATGAC
CTGCAGGAGATGAAGGAAGAGAGTCGGCAGATGATGCGGGAGAAGAAGGTCACCATCCTG
GAGCTGTTCCGCTCCCCCGCCTACCGCCAGCCCATCCTCATCGCTGTGGTGCTGCAGCTG
TCCCAGCAGCTGTCTGGCATCAACGCTGTCTTCTATTACTCCACGAGCATCTTCGAGAAG
GCGGGGGTGCAGCAGCCTGTGTATGCCACCATTGGCTCCGGTATCGTCAACACGGCCTTC
ACTGTCGTGTCGCTGTTTGTGGTGGAGCGAGCAGGCCGGCGGACCCTGCACCTCATAGGC
CTCGCTGGCATGGCGGGTTGTGCCATACTCATGACCATCGCGCTAGCACTGCTGGAGCAG
CTACCCTGGATGTCCTATCTGAGCATCGTGGCCATCTTTGGCTTTGTGGCCTTCTTTGAA
GTGGGTCCTGGCCCCATCCCATGGTTCATCGTGGCTGAACTCTTCAGCCAGGGTCCACGT
CCAGCTGCCATTGCCGTTGCAGGCTTCTCCAACTGGACCTCAAATTTCATTGTGGGCATG
TGCTTCCAGTATGTGGAGCAACTGTGTGGTCCCTACGTCTTCATCATCTTCACTGTGCTC
CTGGTTCTGTTCTTCATCTTCACCTACTTCAAAGTTCCTGAGACTAAAGGCCGGACCTTC
GATGAGATCGCTTCCGGCTTCCGGCAGGGGGGAGCCAGCCAAAGTGATAAGACACCCGAG
GAGCTGTTCCATCCCCTGGGGGCTGATTCCCAAGTGTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
K03195

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_7_Locus:
1p35-p31.3

# Macromolecular_Interacting_Partner_7_SNPs:
rs1385129; rs2236574; rs2229682; rs2306662; rs13306758; rs11537641; rs2229680; rs2229681; rs3199358; rs4658; rs6413525; rs6413524; rs1803656; rs2229683; rs841857; rs841852; rs900836; rs841846; rs841853; rs1770811; rs1770807; rs841858; rs3820548; rs710220; rs6657798; rs2367028; rs3768042; rs751210; rs7515384; rs900835; rs841855; rs2153303; rs3768029; rs841856; rs3820549; rs1770810; rs3754219; rs841851; rs11210766; rs710221; rs2297974; rs4660691; rs3820546; rs3729548; rs3768043; rs2306663; rs17387775; rs10890232; rs3754223; rs17387886; rs900837; rs1105297; rs12407920; rs844500; rs710222; rs2297972; rs12406072; rs841845; rs2086856; rs2297976; rs11808361; rs5031048; rs12718444; rs11799736; rs841854; rs900834; rs863522; rs3768045; rs16830099; rs5031045; rs2086857; rs7512565; rs9803693; rs9804138; rs7522674; rs3754218; rs12071418; rs17387733; rs2297975; rs7534555; rs841849; rs11282849; rs3768044; rs16830121; rs841847; rs16830071; rs841850; rs12565724; rs12130264; rs3820547; rs7512557; rs10890233; rs2297977; rs16830101; rs841848; rs1108902; rs841840; rs3806400; rs3820589; rs4660689; rs3754226; rs11537640; rs3806401; rs13306754; rs5811; rs34025424; rs12876; rs11933; rs11537639; rs2229684; rs11537638; rs1803655; rs11434081; rs3216017; rs34989628; rs34418800; rs10621183; rs3841833; rs34944109; rs3754225; rs35894618; rs35099378; rs34477585; rs710219; rs41310434; rs1622805; rs35734592; rs6696367; rs12080035; rs35343639; rs13306756; rs5031047; rs1770805; rs11576610; rs34128250; rs34394028; rs3835667; rs13306753; rs12080026; rs11210767; rs35739372; rs1681859; rs13306751; rs3768037; rs2200300; rs28658053; rs3831326; rs11401354; rs11439929; rs2297973; rs3841834; rs7512257; rs35883587; rs11294723; rs5031046; rs35181788; rs13306757; rs36015302; rs34964576; rs34790816; rs1572849; rs1054057; rs35637810; rs35565219; rs6675927; rs34502673; rs12066904; rs3216016; rs2367026; rs2001532; rs35745816; rs1770806; rs11451644; rs1681860; rs13306752; rs36090094; rs33944767; rs1770804; rs10683860; rs865193; rs35022307; rs5773795; rs10621182; rs34179281; rs11395781; rs34223767; rs3754224; rs34119304; rs710223; rs2200299; rs3768036; rs28970271; rs11537637; rs12143714; rs35117519; rs2279358; rs6695463; rs12064303; rs28489398; rs3835137; rs9660568; rs9661657; rs28613566; rs36126914; rs6692933; rs35878954; rs11210763; rs11210768; rs11210769; rs11586615; rs11808693; rs12074870; rs12083225; rs12140825; rs2367159; rs35912888; rs3738514; rs3738515; rs710216; rs710217; rs710218; rs710224; rs841839; rs841841; rs841844

# Macromolecular_Interacting_Partner_7_General_References:
3839598; 2834252; 10227690; 10980529; 11603379; 11136715

# Macromolecular_Interacting_Partner_7_References:
17041637; 17043658; 17052934; 17068286

# Macromolecular_Interacting_Partner_8_ID:
7597

# Macromolecular_Interacting_Partner_8_Name:
Solute carrier family 2, facilitated glucose transporter member 2

# Macromolecular_Interacting_Partner_8_Synonyms:
Glucose transporter type 2, liver

# Macromolecular_Interacting_Partner_8_Gene_Name:
SLC2A2

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Solute carrier family 2, facilitated glucose transporter member 2
MTEDKVTGTLVFTVITAVLGSFQFGYDIGVINAPQQVIISHYRHVLGVPLDDRKAINNYV
INSTDELPTISYSMNPKPTPWAEEETVAAAQLITMLWSLSVSSFAVGGMTASFFGGWLGD
TLGRIKAMLVANILSLVGALLMGFSKLGPSHILIIAGRSISGLYCGLISGLVPMYIGEIA
PTALRGALGTFHQLAIVTGILISQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFCP
ESPRYLYIKLDEEVKAKQSLKRLRGYDDVTKDINEMRKEREEASSEQKVSIIQLFTNSSY
RQPILVALMLHVAQQFSGINGIFYYSTSIFQTAGISKPVYATIGVGAVNMVFTAVSVFLV
EKAGRRSLFLIGMSGMFVCAIFMSVGLVLLNKFSWMSYVSMIAIFLFVSFFEIGPGPIPW
FMVAEFFSQGPRPAALAIAAFSNWTCNFIVALCFQYIADFCGPYVFFLFAGVLLAFTLFT
FFKVPETKGKSFEEIAAEFQKKSGSAHRPKAAVEMKFLGATETV

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
524

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
57490

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
8.10

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  carrier activity
Function:  electrochemical potential-driven transporter activity
Function:  porter activity
Function:  sugar porter activity
Function:  transporter activity
Function:  carbohydrate transporter activity
Function:  sugar transporter activity
Function:  monosaccharide transporter activity
Function:  hexose transporter activity
Function:  glucose transporter activity
 ||
>>>
Process:  carbohydrate transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_8_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_8_Specific_Function:
Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00083:Sugar_tr

# Macromolecular_Interacting_Partner_8_Signals:
None

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
11-31
99-119
128-148
159-179
188-208
218-238
304-324
339-359
369-389
401-421
434-454
462-482

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
307125

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
GTR2_HUMAN (P11168)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
SLC2A2

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
SLC2A2

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:11006

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1575 bp
ATGACAGAAGATAAGGTCACTGGGACCCTGGTTTTCACTGTCATCACTGCTGTGCTGGGT
TCCTTCCAGTTTGGATATGACATTGGTGTGATCAATGCACCTCAACAGGTAATAATATCT
CACTATAGACATGTTTTGGGTGTTCCACTGGATGACCGAAAAGCTATCAACAACTATGTT
ATCAACAGTACAGATGAACTGCCCACAATCTCATACTCAATGAACCCAAAACCAACCCCT
TGGGCTGAGGAAGAGACTGTGGCAGCTGCTCAACTAATCACCATGCTCTGGTCCCTGTCT
GTATCCAGCTTTGCAGTTGGTGGAATGACTGCATCATTCTTTGGTGGGTGGCTTGGGGAC
ACACTTGGAAGAATCAAAGCCATGTTAGTAGCAAACATTCTGTCATTAGTTGGAGCTCTC
TTGATGGGGTTTTCAAAATTGGGACCATCTCATATACTTATAATTGCTGGAAGAAGCATA
TCAGGACTATATTGTGGGCTAATTTCAGGCCTGGTTCCTATGTATATCGGTGAAATTGCT
CCAACCGCTCTCAGGGGAGCACTTGGCACTTTTCATCAGCTGGCCATCGTCACGGGCATT
CTTATTAGTCAGATTATTGGTCTTGAATTTATCTTGGGCAATTATGATCTGTGGCACATC
CTGCTTGGCCTGTCTGGTGTGCGAGCCATCCTTCAGTCTCTGCTACTCTTTTTCTGTCCA
GAAAGCCCCAGATACCTTTACATCAAGTTAGATGAGGAAGTCAAAGCAAAACAAAGCTTG
AAAAGACTCAGAGGATATGATGATGTCACCAAAGATATTAATGAAATGAGAAAAGAAAGA
GAAGAAGCATCGAGTGAGCAGAAAGTCTCTATAATTCAGCTCTTCACCAATTCCAGCTAC
CGACAGCCTATTCTAGTGGCACTGATGCTGCATGTGGCTCAGCAATTTTCCGGAATCAAT
GGCATTTTTTACTACTCAACCAGCATTTTTCAGACGGCTGGTATCAGCAAACCTGTTTAT
GCAACCATTGGAGTTGGCGCTGTAAACATGGTTTTCACTGCTGTCTCTGTATTCCTTGTG
GAGAAGGCAGGGCGACGTTCTCTCTTTCTAATTGGAATGAGTGGGATGTTTGTTTGTGCC
ATCTTCATGTCAGTGGGACTTGTGCTGCTGAATAAGTTCTCTTGGATGAGTTATGTGAGC
ATGATAGCCATCTTCCTCTTTGTCAGCTTCTTTGAAATTGGGCCAGGCCCGATCCCCTGG
TTCATGGTGGCTGAGTTTTTCAGTCAAGGACCACGTCCTGCTGCTTTAGCAATAGCTGCA
TTCAGCAATTGGACCTGCAATTTCATTGTAGCTCTGTGTTTCCAGTACATTGCGGACTTC
TGTGGACCTTATGTGTTTTTCCTCTTTGCTGGAGTGCTCCTGGCCTTTACCCTGTTCACA
TTTTTTAAAGTTCCAGAAACCAAAGGAAAGTCTTTTGAGGAAATTGCTGCAGAATTCCAA
AAGAAGAGTGGCTCAGCCCACAGGCCAAAAGCTGCTGTAGAAATGAAATTCCTAGGAGCT
ACAGAGACTGTGTAA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
J03810

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_8_Locus:
3q26.1-q26.2

# Macromolecular_Interacting_Partner_8_SNPs:
rs5400; rs5397; rs7637863; rs1800572; rs5404; rs5405; rs5398; rs5408; rs5401; rs5399; rs7610064; rs1499821; rs1879442; rs1996220; rs11928798; rs8192675; rs12487486; rs11924648; rs11711437; rs5406; rs11917504; rs7643425; rs2292620; rs10513685; rs11711206; rs10513687; rs6785803; rs2129019; rs6806926; rs10513686; rs12488694; rs9828378; rs10513688; rs10513684; rs12633688; rs11920090; rs7356034; rs11925298; rs7646014; rs10513689; rs11720145; rs5402; rs11924032; rs7429478; rs11923694; rs16855638; rs3774046; rs35297160; rs5403; rs6796748; rs9873618; rs12486657; rs12490982; rs9799218; rs5407; rs12487589; rs5396; rs5393; rs5394; rs1280; rs5395; rs16855617; rs2170818; rs2229608; rs28928874; rs35273940; rs35577271; rs28579899; rs12330351; rs11267912; rs13306759; rs10679921; rs6791781; rs35931331; rs35156427; rs34453112; rs3081330; rs35490342; rs3081362; rs34992273; rs34981057; rs5854403; rs35790233; rs6790946; rs6779633; rs35855616; rs13069849; rs13078217; rs7429037; rs28720688; rs35233805; rs2292621; rs5854402; rs10666231; rs11435971; rs11267657; rs35372106; rs35883164; rs34329296; rs34757833; rs11435313; rs13306760; rs34017892; rs731207; rs2292622; rs34358621; rs3215234; rs34369637; rs34528615; rs13090084; rs2859841; rs13098751; rs7625135; rs885445; rs7638998; rs5854404; rs1057904; rs1057903; rs34706115; rs3177521; rs1047094; rs3177516; rs34906618; rs3198465; rs35061096; rs34066960; rs12493271; rs12696316; rs1499820; rs1514895; rs6444956; rs6800110; rs6800180; rs7639688; rs7646791; rs7649712; rs9868410

# Macromolecular_Interacting_Partner_8_General_References:
3399500; 8063045; 8027028; 10987651; 11044475

# Macromolecular_Interacting_Partner_8_References:
17032938

# Macromolecular_Interacting_Partner_9_ID:
7609

# Macromolecular_Interacting_Partner_9_Name:
Solute carrier family 2, facilitated glucose transporter member 4

# Macromolecular_Interacting_Partner_9_Synonyms:
Glucose transporter type 4, insulin-responsive

# Macromolecular_Interacting_Partner_9_Gene_Name:
SLC2A4

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Solute carrier family 2, facilitated glucose transporter member 4
MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETW
LGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAV
LGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAI
VIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPA
RKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQL
SGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGM
CGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAM
AVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQIS
AAFHRTPSLLEQEVKPSTELEYLGPDEND

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
509

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
54788

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
6.94

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  carrier activity
Function:  electrochemical potential-driven transporter activity
Function:  porter activity
Function:  sugar porter activity
Function:  transporter activity
Function:  carbohydrate transporter activity
Function:  sugar transporter activity
Function:  monosaccharide transporter activity
Function:  hexose transporter activity
Function:  glucose transporter activity
 ||
>>>
Process:  carbohydrate transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_9_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_9_Specific_Function:
Insulin-regulated facilitative glucose transporter

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00083:Sugar_tr

# Macromolecular_Interacting_Partner_9_Signals:
None

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
25-45
82-102
112-132
143-163
172-192
202-222
288-308
324-344
354-374
385-405
418-438
446-466

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
307076

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
GTR4_HUMAN (P14672)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
SLC2A4

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
SLC2A4

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:11009

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Intracytoplasmic membrane; multi-pass membrane protein. Cytoplasm; perinuclear region. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>1530 bp
ATGCCGTCGGGCTTCCAACAGATAGGCTCCGAAGATGGGGAACCCCCTCAGCAGCGAGTG
ACTGGGACCCTGGTCCTTGCTGTGTTCTCTGCGGTGCTTGGCTCCCTGCAGTTTGGGTAC
AACATTGGGGTCATCAATGCCCCTCAGAAGGTGATTGAACAGAGCTACAATGAGACGTGG
CTGGGGAGGCAGGGGCCTGAGGGACCCAGCTCCATCCCTCCAGGCACCCTCACCACCCTC
TGGGCCCTCTCCGTGGCCATCTTTTCCGTGGGCGGCATGATTTCCTCCTTCCTCATTGGT
ATCATCTCTCAGTGGCTTGGAAGGAAAAGGGCCATGCTGGTCAACAATGTCCTGGCGGTG
CTGGGGGGCAGCCTCATGGGCCTGGCCAACGCTGCTGCCTCCTATGAAATGCTCATCCTT
GGACGATTCCTCATTGGCGCCTACTCAGGGCTGACATCAGGGCTGGTGCCCATGTACGTG
GGGGAGATTGCTCCCACTCACCTGCGGGGCGCCCTGGGGACGCTCAACCAACTGGCCATT
GTTATCGGCATTCTGATCGCCCAGGTGCTGGGCTTGGAGTCCCTCCTGGGCACTGCCAGC
CTGTGGCCACTGCTCCTGGGCCTCACAGTGCTACCTGCCCTCCTGCAGCTGGTCCTGCTG
CCCTTCTGTCCCGAGAGCCCCCGCTACCTCTACATCATCCAGAATCTCGAGGGGCCTGCC
AGAAAGAGTCTGAAGCGCCTGACAGGCTGGGCCGATGTTTCTGGAGTGCTGGCTGAGCTG
AAGGATGAGAAGCGGAAGCTGGAGCGTGAGCGGCCACTGTCCCTGCTCCAGCTCCTGGGC
AGCCGTACCCACCGGCAGCCCCTGATCATTGCGGTCGTGCTGCAGCTGAGCCAGCAGCTC
TCTGGCATCAATGCTGTTTTCTATTATTCGACCAGCATCTTCGAGACAGCAGGGGTAGGC
CAGCCTGCCTATGCCACCATAGGAGCTGGTGTGGTCAACACAGTCTTCACCTTGGTCTCG
GTGTTGTTGGTGGAGCGGGCGGGGCGCCGGACGCTCCATCTCCTGGGCCTGGCGGGCATG
TGTGGCTGTGCCATCCTGATGACTGTGGCTCTGCTCCTGCTGGAGCGAGTTCCAGCCATG
AGCTACGTCTCCATTGTGGCCATCTTTGGCTTCGTGGCATTTTTTGAGATTGGCCCTGGC
CCCATTCCTTGGTTCATCGTGGCCGAGCTCTTCAGCCAGGGACCCCGCCCGGCAGCCATG
GCTGTGGCTGGTTTCTCCAACTGGACGAGCAACTTCATCATTGGCATGGGTTTCCAGTAT
GTTGCGGAGGCTATGGGGCCCTACGTCTTCCTTCTATTTGCGGTCCTCCTGCTGGGCTTC
TTCATCTTCACCTTCTTAAGAGTACCTGAAACTCGAGGCCGGACGTTTGACCAGATCTCA
GCTGCCTTCCACCGGACACCCTCTCTTTTAGAGCAGGAGGTGAAACCCAGCACAGAACTT
GAGTATTTAGGGCCAGATGAGAACGACTGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
M20747

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_9_Locus:
17p13

# Macromolecular_Interacting_Partner_9_SNPs:
rs35198331; rs8192702; rs5434; rs5435; rs5418; rs5417; rs5420; rs5433; rs5419; rs5432; rs5427; rs5424; rs5423; rs5430; rs5428; rs9282855; rs5425; rs8082645; rs5426; rs5429; rs5422; rs5431; rs222849; rs16956647; rs5436; rs222847; rs5412; rs2654185; rs9902838; rs5415; rs2073476; rs5410; rs5413; rs5414; rs5409; rs5411; rs13306763; rs8192703; rs5819152; rs9894700; rs35035718; rs35240617; rs35584159; rs3744402; rs12937142; rs13306762; rs5437; rs41312262; rs222848; rs5421; rs5416; rs12952287; rs36118623; rs13306761; rs12951254; rs1634382; rs178472; rs222838; rs222839; rs222840; rs222842; rs2521992; rs2654189; rs35878719; rs3744404; rs3744405; rs391768; rs7208604; rs7210715; rs7211312; rs7503500; rs8073449; rs8076649; rs924703; rs9907557

# Macromolecular_Interacting_Partner_9_General_References:
2656669; 1397719; 7916714; 11842083; 8300557; 1918382; 1756912; 1521731

# Macromolecular_Interacting_Partner_9_References:
17035674; 17038550; 17050738; 17072583

# Macromolecular_Interacting_Partner_10_ID:
7612

# Macromolecular_Interacting_Partner_10_Name:
Vascular endothelial growth factor A precursor

# Macromolecular_Interacting_Partner_10_Synonyms:
VEGF-A; Vascular permeability factor; VPF

# Macromolecular_Interacting_Partner_10_Gene_Name:
VEGF

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Vascular endothelial growth factor A precursor
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD
IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM
SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPG
PHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
232

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
27043

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
9.08

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00341:PDGF

# Macromolecular_Interacting_Partner_10_Signals:
1-26

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
181971

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
VEGFA_HUMAN (P15692)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
VEGF

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
VEGF

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:12680

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Secreted protein. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell- associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>576 bp
ATGAACTTTCTGCTGTCTTGGGTGCATTGGAGCCTCGCCTTGCTGCTCTACCTCCACCAT
GCCAAGTGGTCCCAGGCTGCACCCATGGCAGAAGGAGGAGGGCAGAATCATCACGAAGTG
GTGAAGTTCATGGATGTCTATCAGCGCAGCTACTGCCATCCAATCGAGACCCTGGTGGAC
ATCTTCCAGGAGTACCCTGATGAGATCGAGTACATCTTCAAGCCATCCTGTGTGCCCCTG
ATGCGATGCGGGGGCTGCTGCAATGACGAGGGCCTGGAGTGTGTGCCCACTGAGGAGTCC
AACATCACCATGCAGATTATGCGGATCAAACCTCACCAAGGCCAGCACATAGGAGAGATG
AGCTTCCTACAGCACAACAAATGTGAATGCAGACCAAAGAAAGATAGAGCAAGACAAGAA
AATCCCTGTGGGCCTTGCTCAGAGCGGAGAAAGCATTTGTTTGTACAAGATCCGCAGACG
TGTAAATGTTCCTGCAAAAACACAGACTCGCGTTGCAAGGCGAGGCAGCTTGAGTTAAAC
GAACGTACTTGCAGATGTGACAAGCCGAGGCGGTGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
M32977

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_10_Locus:
6p12

# Macromolecular_Interacting_Partner_10_SNPs:
Not Available

# Macromolecular_Interacting_Partner_10_General_References:
2479986; 2479987; 1711045; 1791831; 1567395; 9054410; 9878851; 9450968; 10464055; 14574404; 7678805; 2584205; 10067980; 9207067; 9351807; 9922142; 9336848; 9634701; 11427521

# Macromolecular_Interacting_Partner_10_References:
17065333; 17100551

# Macromolecular_Interacting_Partner_11_ID:
6681

# Macromolecular_Interacting_Partner_11_Name:
RAC-alpha serine/threonine-protein kinase

# Macromolecular_Interacting_Partner_11_Synonyms:
RAC-PK-alpha; Protein kinase B; PKB; C-AKT

# Macromolecular_Interacting_Partner_11_Gene_Name:
AKT1

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>RACalpha serine/threonineprotein kinase
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA


# Macromolecular_Interacting_Partner_11_Number_of_Residues:
480

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
55687

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
5.96

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_11_General_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Specific_Function:
General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis, partly by playing a role in both insulin-induced phosphorylation of 4E-BP1 and in insulin-induced activation of p70 S6 kinase. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF00169:PH;
PF00069:Pkinase;
PF00433:Pkinase_C

# Macromolecular_Interacting_Partner_11_Signals:
None

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
EC 2.7.11.1

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
190828

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
AKT1_HUMAN (P31749)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
AKT1

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
AKT1

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:391

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Cytoplasm. Nucleus. Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1)

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>1443 bp
ATGAGCGACGTGGCTATTGTGAAGGAGGGTTGGCTGCACAAACGAGGGGAGTACATCAAG
ACCTGGCGGCCACGCTACTTCCTCCTCAAGAATGATGGCACCTTCATTGGCTACAAGGAG
CGGCCGCAGGATGTGGACCAACGTGAGGCTCCCCTCAACAACTTCTCTGTGGCGCAGTGC
CAGCTGATGAAGACGGAGCGGCCCCGGCCCAACACCTTCATCATCCGCTGCCTGCAGTGG
ACCACTGTCATCGAACGCACCTTCCATGTGGAGACTCCTGAGGAGCGGGAGGAGTGGACA
ACCGCCATCCAGACTGTGGCTGACGGCCTCAAGAAGCAGGAGGAGGAGGAGATGGACTTC
CGGTCGGGCTCACCCAGTGACAACTCAGGGGCTGAAGAGATGGAGGTGTCCCTGGCCAAG
CCCAAGCACCGCGTGACCATGAACGAGTTTGAGTACCTGAAGCTGCTGGGCAAGGGCACT
TTCGGCAAGGTGATCCTGGTGAAGGAGAAGGCCACAGGCCGCTACTACGCCATGAAGATC
CTCAAGAAGGAAGTCATCGTGGCCAAGGACGAGGTGGCCCACACACTCACCGAGAACCGC
GTCCTGCAGAACTCCAGGCACCCCTTCCTCACAGCCCTGAAGTACTCTTTCCAGACCCAC
GACCGCCTCTGCTTTGTCATGGAGTACGCCAACGGGGGCGAGCTGTTCTTCCACCTGTCC
CGGGAACGTGTGTTCTCCGAGGACCGGGCCCGCTTCTATGGCGCTGAGATTGTGTCAGCC
CTGGACTACCTGCACTCGGAGAAGAACGTGGTGTACCGGGACCTCAAGCTGGAGAACCTC
ATGCTGGACAAGGACGGGCACATTAAGATCACAGACTTCGGGCTGTGCAAGGAGGGGATC
AAGGACGGTGCCACCATGAAGACCTTTTGCGGCACACCTGAGTACCTGGCCCCCGAGGTG
CTGGAGGACAATGACTACGGCCGTGCAGTGGACTGGTGGGGGCTGGGCGTGGTCATGTAC
GAGATGATGTGCGGTCGCCTGCCCTTCTACAACCAGGACCATGAGAAGCTTTTTGAGCTC
ATCCTCATGGAGGAGATCCGCTTCCCGCGCACGCTTGGTCCCGAGGCCAAGTCCTTGCTT
TCAGGGCTGCTCAAGAAGGACCCCAAGCAGAGGCTTGGCGGGGGCTCCGAGGACGCCAAG
GAGATCATGCAGCATCGCTTCTTTGCCGGTATCGTGTGGCAGCACGTGTACGAGAAGAAG
CTCAGCCCACCCTTCAAGCCCCAGGTCACGTCGGAGACTGACACCAGGTATTTTGATGAG
GAGTTCACGGCCCAGATGATCACCATCACACCACCTGACCAAGATGACAGCATGGAGTGT
GTGGACAGCGAGCGCAGGCCCCACTTCCCCCAGTTCTCCTACTCGGCCAGCAGCACGGCC
TGA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
M63167

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_11_Locus:
14q32.32|14q32.32

# Macromolecular_Interacting_Partner_11_SNPs:
rs1130233; rs2230506; rs2230508; rs1130214; rs28634999; rs35416681; rs34558581; rs3803305; rs36214921; rs1130245; rs34757714; rs34790457; rs34865723; rs10144641; rs10138227; rs2494735; rs2494732; rs2494738; rs4375597; rs2494743; rs2494731; rs2494742; rs3730329; rs11849304; rs3730344; rs3001371; rs2494746; rs2498789; rs10149779; rs2494748; rs7140735; rs2498796; rs3803304; rs3730362; rs2494741; rs11848899; rs3730358; rs3730368; rs12588965; rs2494739; rs3730328; rs6576060; rs2494737; rs34410130; rs2498791; rs2494749; rs11848695; rs3730330; rs10136000; rs2494740; rs35635404; rs2498793; rs34664585; rs12432267; rs35622471; rs10142069; rs11848805; rs17846832; rs2498797; rs12436999; rs2498788; rs36214559; rs2494744; rs2498794; rs3730346; rs3730361; rs36214558; rs12437017; rs35314414; rs35586636; rs2498802; rs2494750; rs2494751; rs2498786; rs2498801; rs2494752; rs11555433; rs34409589; rs11555435; rs11555436; rs12881616; rs11555431; rs11555432; rs11555434; rs17846825; rs34670300; rs17846831; rs17846828; rs3840005; rs17102385; rs11555428; rs17846829; rs11555430; rs11555429; rs17846821; rs17846826; rs34830023; rs41307094; rs1130443; rs3001372; rs1130295; rs11391511; rs1130526; rs1804268; rs3002448; rs28730786; rs35285446; rs5811151; rs3730360; rs28535133; rs5811153; rs2498800; rs2498792; rs2494734; rs36214560; rs33931844; rs2498795; rs35707077; rs2494745; rs35858243; rs3730342; rs11382683; rs5811152; rs12433614; rs34907636; rs10149034; rs35478693; rs4076736; rs3002451; rs7143802; rs35641875; rs36214556; rs36214914; rs5811154; rs35288747; rs33938935; rs36214916; rs17846818; rs34530493; rs34326349; rs36214562; rs11847866; rs35939172; rs12590657; rs34782376; rs35330545; rs2494733; rs17846822; rs11851662; rs36214915; rs2494736; rs34119321; rs2498798; rs28379051; rs6145483; rs8192700; rs36214557; rs2498787; rs34402148; rs3730345; rs2494747; rs17846816; rs34449645; rs10141765; rs3730348; rs17846812; rs12897418; rs33970580; rs7160999; rs5811155; rs34391967; rs28546406; rs10141867; rs14905; rs2498784; rs2498785; rs2498804; rs33925946; rs34284721; rs3803299; rs3803300; rs4132468; rs4145854; rs4983387; rs7151243; rs9989156

# Macromolecular_Interacting_Partner_11_General_References:
1851997; 11508278; 1718748; 1533586; 9736715; 8978681; 11994271; 12149249

# Macromolecular_Interacting_Partner_11_References:
17028898; 17051390; 17062841

# Macromolecular_Interacting_Partner_12_ID:
7654

# Macromolecular_Interacting_Partner_12_Name:
Insulin receptor substrate 1

# Macromolecular_Interacting_Partner_12_Synonyms:
IRS-1

# Macromolecular_Interacting_Partner_12_Gene_Name:
IRS1

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Insulin receptor substrate 1
MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPN
GHYILSRGGNGHRCTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTRSYPEEGLEMHPLERRGGHHR
PDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN
GYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGTSYGKLWTNGVGGHHSHVLPHPKPPVES
SGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEP
EEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPH
LPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQPLLHPPEPKSPGEYVNIE
FGSDQSGYLSGPVAFHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQESTGV
EMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIA
AEEVSLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSPN
RNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSSSSEDVKR
HSSASFENVWLRPGELGGAPKEPAKLCGAAGGLENGLNYIDLDLVKDFKQCPQECTPEPQ
PPPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDRQ

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
1242

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
131592

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
8.66

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  insulin receptor binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF02174:IRS;
PF00169:PH

# Macromolecular_Interacting_Partner_12_Signals:
None

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
246466

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
IRS1_HUMAN (P35568)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
IRS1

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
IRS1

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:6125

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>3732 bp
ATGGCGAGCCCTCCGGAGAGCGATGGCTTCTCGGACGTGCGCAAGGTGGGCTACCTGCGC
AAACCCAAGAGCATGCACAAACGCTTCTTCGTACTGCGCGCGGCCAGCGAGGCTGGGGGC
CCGGCGCGCCTCGAGTACTACGAGAACGAGAAGAAGTGGCGGCACAAGTCGAGCGCCCCC
AAACGCTCGATCCCCCTTGAGAGCTGCTTCAACATCAACAAGCGGGCTGACTCCAAGAAC
AAGCACCTGGTGGCTCTCTACACCCGGGACGAGCACTTTGCCATCGCGGCGGACAGCGAG
GCCGAGCAAGACAGCTGGTACCAGGCTCTCCTACAGCTGCACAACCGTGCTAAGGGCCAC
CACGACGGAGCTGCGGCCCTCGGGGCGGGAGGTGGTGGTGGGGGCAGCTGCAGCGGCAGC
TCCGGCCTTGGTGAGGCTGGGGAGGACTTGAGCTACGGTGACGTGCCCCCAGGACCCGCA
TTCAAAGAGGTCTGGCAAGTGATCCTGAAGCCCAAGGGCCTGGGTCAGACAAAGAACCTG
ATTGGTATCTACCGCCTTTGCCTGACCAGCAAGACCATCAGCTTCGTGAAGCTGAACTCG
GAGGCAGCGGCCGTGGTGCTGCAGCTGATGAACATCAGGCGCTGTGGCCACTCGGAAAAC
TTCTTCTTCATCGAGGTGGGCCGTTCTGCCGTGACGGGGCCCGGGGAGTTCTGGATGCAG
GTGGATGACTCTGTGGTGGCCCAGAACATGCACGAGACCATCCTGGAGGCCATGCGGGCC
ATGAGCGATGAGTTCCGCCCTCGCAGCAAGAGCCAGTCCTCGTCCAACTGCTCTAACCCC
ATCAGCGTCCCCCTGCGCCGGCACCATCTCAACAATCCCCCGCCCAGCCAGGTGGGGCTG
ACCCGCCGATCACGCACTGAGAGCATCACCGCCACCTCCCCGGCCAGCATGGTGGGCGGG
AAGCCAGGCTCCTTCCGTGTCCGCGCCTCCAGTGACGGCGAAGGCACCATGTCCCGCCCA
GCCTCGGTGGACGGCAGCCCTGTGAGTCCCAGCACCAACAGAACCCACGCCCACCGGCAT
CGGGGCAGGGCCCGGCTGCACCCCCCGCTCAACCACAGCCGCTCCATCCCCATGCCGGCT
TCCCGCTGCTCCCGTTCGGCCACCAGCCCGGTCAGTCTGTCGTCCAGTAGCACCAGTGGC
CATGGCTCCACCTCGGATTGTCTCTTCCCACGGCGATCTAGTGCTTCGGTGTCTGGTTCC
CCCAGCGATGGCGGTTTCATCTCCTCGGATGAGTATGGCTCCAGTCCCTGCGATTTCCGG
AGTTCCTTCCGCAGTGTCACTCCGGATTCCCTGGGCCACACCCCACCAGCCCGCGGTGAG
GAGGAGCTAAGCAACTATATCTGCATGGGTGGCAAGGGGCCCTCCACCCTGACCGCCCCC
AACGGTCACTACATTTTGTCTCGGGGTGGCAATGGCCACCGCTGCACCCCAGGAACAGGC
TTGGGCACGAGTCCAGCCTTGGCTGGGGATGAAGCAGCCAGTGCTGCAGATCTGGATAAT
CGGTTCCGAAAGAGAACTCACTCGGCAGGCACATCCCCTACCATTACCCACCAGAAGACC
CCGTCCCAGTCCTCAGTGGCTTCCATTGAGGAGTACACAGAGATGATGCCTGCCTACCCA
CCAGGAGGTGGCAGTGGAGGCCGACTGCCGGGACACAGGCACTCCGCCTTCGTGCCCACC
CGCTCCTACCCAGAGGAGGGTCTGGAAATGCACCCCTTGGAGCGTCGGGGGGGGCACCAC
CGCCCAGACAGCTCCACCCTCCACACGGATGATGGCTACATGCCCATGTCCCCAGGGGTG
GCCCCAGTGCCCAGTGGCCGAAAGGGCAGTGGAGACTATATGCCCATGAGCCCCAAGAGC
GTATCTGCCCCACAGCAGATCATCAATCCCATCAGACGCCATCCCCAGAGAGTGGACCCC
AATGGCTACATGATGATGTCCCCCAGCGGTGGCTGCTCTCCTGACATTGGAGGTGGCCCC
AGCAGCAGCAGCAGCAGCAGCAACGCCGTCCCTTCCGGGACCAGCTATGGAAAGCTGTGG
ACAAACGGGGTAGGGGGCCACCACTCTCATGTCTTGCCTCACCCCAAACCCCCAGTGGAG
AGCAGCGGTGGTAAGCTCTTACCTTGCACAGGTGACTACATGAACATGTCACCAGTGGGG
GACTCCAACACCAGCAGCCCCTCCGACTGCTACTACGGCCCTGAGGACCCCCAGCACAAG
CCAGTCCTCTCCTACTACTCATTGCCAAGATCCTTTAAGCACACCCAGCGCCCCGGGGAG
CCGGAGGAGGGTGCCCGGCATCAGCACCTCCGCCTTTCCACTAGCTCTGGTCGCCTTCTC
TATGCTGCAACAGCAGATGATTCTTCCTCTTCCACCAGCAGCGACAGCCTGGGTGGGGGA
TACTGCGGGGCTAGGCTGGAGCCCAGCCTTCCACATCCCCACCATCAGGTTCTGCAGCCC
CATCTGCCTCGAAAGGTGGACACAGCTGCTCAGACCAATAGCCGCCTGGCCCGGCCCACG
AGGCTGTCCCTGGGGGATCCCAAGGCCAGCACCTTACCTCGGGCCCGAGAGCAGCAGCAG
CAGCAGCAGCCCTTGCTGCACCCTCCAGAGCCCAAGAGCCCGGGGGAATATGTCAATATT
GAATTTGGGAGTGATCAGTCTGGCTACTTGTCTGGCCCGGTGGCTTTCCACAGCTCACCT
TCTGTCAGGTGTCCATCCCAGCTCCAGCCAGCTCCCAGAGAGGAAGAGACTGGCACTGAG
GAGTACATGAAGATGGACCTGGGGCCGGGCCGGAGGGCAGCCTGGCAGGAGAGCACTGGG
GTCGAGATGGGCAGACTGGGCCCTGCACCTCCCGGGGCTGCTAGCATTTGCAGGCCTACC
CGGGCAGTGCCCAGCAGCCGGGGTGACTACATGACCATGCAGATGAGTTGTCCCCGTCAG
AGCTACGTGGACACCTCGCCAGCTGCCCCTGTAAGCTATGCTGACATGCGAACAGGCATT
GCTGCAGAGGAGGTGAGCCTGCCCAGGGCCACCATGGCTGCTGCCTCCTCATCCTCAGCA
GCCTCTGCTTCCCCGACTGGGCCTCAAGGGGCAGCAGAGCTGGCTGCCCACTCGTCCCTG
CTGGGGGGCCCACAAGGACCTGGGGGCATGAGCGCCTTCACCCGGGTGAACCTCAGTCCT
AACCGCAACCAGAGTGCCAAAGTGATCCGTGCAGACCCACAAGGGTGCCGGCGGAGGCAT
AGCTCCGAGACTTTCTCCTCAACACCCAGTGCCACCCGGGTGGGCAACACAGTGCCCTTT
GGAGCGGGGGCAGCAGTAGGGGGCGGTGGCGGTAGCAGCAGCAGCAGCGAGGATGTGAAA
CGCCACAGCTCTGCTTCCTTTGAGAATGTGTGGCTGAGGCCTGGGGAGCTTGGGGGAGCC
CCCAAGGAGCCAGCCAAACTGTGTGGGGCTGCTGGGGGTTTGGAGAATGGTCTTAACTAC
ATAGACCTGGATTTGGTCAAGGACTTCAAACAGTGCCCTCAGGAGTGCACCCCTGAACCG
CAGCCTCCCCCACCCCCACCCCCTCATCAACCCCTGGGCAGCGGTGAGAGCAGCTCCACC
CGCCGCTCAAGTGAGGATTTAAGCGCCTATGCCAGCATCAGTTTCCAGAAGCAGCCAGAG
GACCGTCAGTAG

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
S85963

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_12_Locus:
2q36

# Macromolecular_Interacting_Partner_12_SNPs:
rs3731594; rs1801278; rs1801276; rs1801118; rs2234931; rs3731596; rs2229613; rs1801123; rs3731597; rs1366757; rs10179720; rs1560252; rs9288616; rs10181778; rs10205923; rs1820841; rs9653366; rs1025333; rs4675095; rs10205233; rs13431179; rs4675093; rs16822623; rs10498211; rs16822647; rs17208470; rs10178285; rs4675094; rs16822615; rs7556692; rs4294992; rs10182336; rs10498210; rs11900752; rs12052364; rs16822633; rs10498212; rs3769647; rs16822604; rs16822638; rs13401886; rs16822609; rs2894611; rs1078533; rs16822640; rs2435182; rs16822607; rs2435185; rs16822625; rs16822652; rs16822626; rs35802832; rs6754575; rs17347714; rs16822627; rs13427008; rs10207942; rs17268434; rs10173960; rs10170494; rs16822644; rs16822636; rs17508368; rs2435186; rs16822630; rs16822573; rs10170579; rs16822574; rs16822628; rs7567312; rs16822579; rs9282770; rs16822601; rs16822642; rs6436635; rs16822570; rs11687038; rs1801108; rs13306470; rs41265094; rs1801120; rs13306466; rs12999226; rs11554580; rs1801277; rs13306469; rs13306467; rs13306468; rs1801112; rs41272723; rs34909077; rs35319654; rs1801119; rs35909627; rs34857960; rs34294898; rs34692391; rs4641921; rs35750474; rs2464987; rs10681471; rs35498416; rs4261709; rs5839180; rs13418700; rs35138140; rs35259831; rs34286846; rs34926444; rs35587446; rs34534791; rs13405260; rs34425805; rs34695433; rs34319959; rs6749638; rs28407115; rs35636509; rs35549956; rs13306465; rs28415492; rs35168801; rs28376161; rs35497390; rs35847201; rs13402124; rs11450624; rs13418829; rs2115598; rs10203149; rs35878583; rs35699614; rs2435184; rs13017342; rs35601172; rs3054797; rs34763265; rs6741302; rs12993944; rs10203; rs12105563; rs36040151; rs12617308; rs2464988; rs6710982; rs12994352; rs35302226; rs10201995; rs6749796; rs35420063; rs28695886; rs1529525; rs35954822; rs13306464; rs36047314; rs919423; rs34333258; rs15625; rs34459501; rs13418923; rs35327882; rs2435187; rs3054795; rs2435183; rs16822572; rs34557881; rs11680568; rs10168135; rs35930683; rs12105210; rs2033289; rs3832077; rs36216459; rs36028791; rs34870127; rs35214757; rs10199296; rs10207051; rs10211473; rs10211582; rs11690232; rs12053536; rs12467147; rs13018009; rs13392876; rs13423855; rs13431554; rs1560251; rs17208078; rs17208239; rs1896832; rs2288585; rs2288586; rs2288587; rs2894610; rs4675096; rs5017950; rs6725330; rs6725556; rs934167

# Macromolecular_Interacting_Partner_12_General_References:
8513971; 1311924; 8240352; 7541045; 7559478; 12624099; 8599766; 8104271; 8723689

# Macromolecular_Interacting_Partner_12_References:
17121043

# Macromolecular_Interacting_Partner_13_ID:
7657

# Macromolecular_Interacting_Partner_13_Name:
Peroxisome proliferator-activated receptor gamma

# Macromolecular_Interacting_Partner_13_Synonyms:
PPAR-gamma

# Macromolecular_Interacting_Partner_13_Gene_Name:
PPARG

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Peroxisome proliferatoractivated receptor gamma
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
505

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
57621

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
5.77

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
Function:  steroid hormone receptor activity
Function:  transcription factor activity
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_13_Signals:
None

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
1711117

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
PPARG_HUMAN (P37231)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
PPARG

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
PPARG

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:9236

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>1518 bp
ATGGGTGAAACTCTGGGAGATTCTCCTATTGACCCAGAAAGCGATTCCTTCACTGATACA
CTGTCTGCAAACATATCACAAGAAATGACCATGGTTGACACAGAGATGCCATTCTGGCCC
ACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCACTCCTTT
GATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGAC
ATTCCATTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATGACCTGAAACTTCAA
GAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAGAAGACT
CAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGT
GTCTGTGGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAG
GGTTTCTTCCGGAGAACAATCAGATTGAAGCTTATCTATGACAGATGTGATCTTAACTGT
CGGATCCACAAAAAAAGTAGAAATAAATGTCAGTACTGTCGGTTTCAGAAATGCCTTGCA
GTGGGGATGTCTCATAATGCCATCAGGTTTGGGCGGATGCCACAGGCCGAGAAGGAGAAG
CTGTTGGCGGAGATCTCCAGTGATATCGACCAGCTGAATCCAGAGTCCGCTGACCTCCGG
GCCCTGGCAAAACATTTGTATGACTCATACATAAAGTCCTTCCCGCTGACCAAAGCAAAG
GCGAGGGCGATCTTGACAGGAAAGACAACAGACAAATCACCATTCGTTATCTATGACATG
AATTCCTTAATGATGGGAGAAGATAAAATCAAGTTCAAACACATCACCCCCCTGCAGGAG
CAGAGCAAAGAGGTGGCCATCCGCATCTTTCAGGGCTGCCAGTTTCGCTCCGTGGAGGCT
GTGCAGGAGATCACAGAGTATGCCAAAAGCATTCCTGGTTTTGTAAATCTTGACTTGAAC
GACCAAGTAACTCTCCTCAAATATGGAGTCCACGAGATCATTTACACAATGCTGGCCTCC
TTGATGAATAAAGATGGGGTTCTCATATCCGAGGGCCAAGGCTTCATGACAAGGGAGTTT
CTAAAGAGCCTGCGAAAGCCTTTTGGTGACTTTATGGAGCCCAAGTTTGAGTTTGCTGTG
AAGTTCAATGCACTGGAATTAGATGACAGCGACTTGGCAATATTTATTGCTGTCATTATT
CTCAGTGGAGACCGCCCAGGTTTGCTGAATGTGAAGCCCATTGAAGACATTCAAGACAAC
CTGCTACAAGCCCTGGAGCTCCAGCTGAAGCTGAACCACCCTGAGTCCTCACAGCTGTTT
GCCAAGCTGCTCCAGAAAATGACAGACCTCAGACAGATTGTCACGGAACACGTGCAGCTA
CTGCAGGTGATCAAGAAGACGGAGACAGACATGAGTCTTCACCCGCTCCTGCAGGAGATC
TACAAGGACTTGTACTAG

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
U79012

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_13_Locus:
3p25

# Macromolecular_Interacting_Partner_13_SNPs:
rs1801282; rs3856806; rs4135352; rs13306747; rs1805151; rs2921188; rs2881654; rs6776454; rs12496005; rs2197423; rs4135307; rs4135315; rs4135316; rs880663; rs9829551; rs11128598; rs12636454; rs4135304; rs4135255; rs4135322; rs12631389; rs6800910; rs4135311; rs12487012; rs4135321; rs4135305; rs1064323; rs6800748; rs12496505; rs2120825; rs4135301; rs10510412; rs2028759; rs4135323; rs6802898; rs12629240; rs7647481; rs13095716; rs4135313; rs4684101; rs6805419; rs4135302; rs7627605; rs6809631; rs9310401; rs4135245; rs9817428; rs1899951; rs2938397; rs4135259; rs4135308; rs10865710; rs11715073; rs4684848; rs4135320; rs3885307; rs6778740; rs12629293; rs4135246; rs12636461; rs13433696; rs1373641; rs9812662; rs12639162; rs4135306; rs12633551; rs12497191; rs9858822; rs12629751; rs4135253; rs7648033; rs1596667; rs11128597; rs13083375; rs13070963; rs2007629; rs12630210; rs4135254; rs11128601; rs4135258; rs10510410; rs4135310; rs4145574; rs4135317; rs7646510; rs7636145; rs17036342; rs6768587; rs7620165; rs2012444; rs6798974; rs4135256; rs3892175; rs13073869; rs1122648; rs6782178; rs4145573; rs10510411; rs4135319; rs4135318; rs2938398; rs2972167; rs964232; rs4135247; rs2028760; rs17036328; rs10510418; rs9883281; rs11128603; rs4135312; rs6442311; rs12493718; rs9851767; rs2921189; rs11128599; rs17817276; rs6785890; rs13061415; rs2938396; rs4135248; rs4135257; rs4135303; rs6442310; rs12485478; rs7638903; rs7617488; rs28763893; rs4135250; rs17793693; rs12490265; rs17036326; rs7646425; rs4135249; rs2972164; rs1373640; rs17036263; rs4135251; rs4135314; rs12631819; rs11710969; rs7638788; rs17036321; rs11128596; rs4135309; rs12639094; rs17036188; rs6795085; rs12629497; rs3112395; rs6808179; rs2920505; rs12631028; rs6795946; rs13064760; rs6809832; rs35206526; rs7649970; rs17036314; rs11128600; rs4684845; rs10865711; rs12631322; rs7615916; rs9882725; rs9849386; rs2067819; rs11716748; rs17817469; rs17029006; rs4684846; rs2881479; rs17036242; rs6788489; rs11719186; rs6792284; rs4073770; rs12634544; rs2972168; rs2921190; rs9842021; rs13306745; rs11715016; rs11128602; rs13076055; rs12496413; rs7610055; rs9823137; rs9883193; rs17435731; rs2346795; rs4362702; rs10510417; rs6768049; rs12330440; rs12495364; rs9814788; rs17029008; rs2067820; rs6766920; rs11709077; rs2960422; rs17425935; rs17036163; rs17036281; rs17036160; rs6801982; rs4518111; rs17050719; rs3112393; rs4684847; rs17036174; rs17036282; rs10212597; rs34359034; rs17036165; rs35080475; rs17036333; rs17793951; rs1984669; rs17036170; rs12486170; rs9876942; rs12635309; rs4315668; rs11718775; rs9870196; rs3963364; rs1373642; rs1822825; rs2959273; rs2938394; rs2938392; rs1151998; rs709149; rs796313; rs709156; rs1175543; rs1175540; rs2959272; rs2972162; rs1875796; rs1151996; rs1151997; rs1797912; rs709154; rs796290; rs4135359; rs4135343; rs4135260; rs4135354; rs1152002; rs4135293; rs709157; rs4135327; rs709148; rs4135358; rs709152; rs4135329; rs4135344; rs2938395; rs4135263; rs4135330; rs1177809; rs4135345; rs4135296; rs4135264; rs1151999; rs2655259; rs4135324; rs4135332; rs4135276; rs709147; rs4135356; rs709151; rs4135362; rs6442313; rs709158; rs4135282; rs4135333; rs6442312; rs4135281; rs1175541; rs1175542; rs4135340; rs4135277; rs4135350; rs2938387; rs4135266; rs4135288; rs7626560; rs4135341; rs2921193; rs4135285; rs4135361; rs4135348; rs4135326; rs2938389; rs4135347; rs4135351; rs4135261; rs2972163; rs4135337; rs4135292; rs4135286; rs709155; rs2938388; rs10510420; rs4135299; rs4135283; rs2959271; rs4135273; rs4135294; rs7645903; rs4135284; rs4135335; rs4135280; rs709150; rs4135274; rs4135357; rs4135289; rs6794024; rs709153; rs4135331; rs1152001; rs7650895; rs4135336; rs1699337; rs2959269; rs4135346; rs4135265; rs4135275; rs4135278; rs4135297; rs6782475; rs4135295; rs4135355; rs10510419; rs4135334; rs4135338; rs4135290; rs2959268; rs4135360; rs4135298; rs2292101; rs4135349; rs4135287; rs895095; rs4135267; rs4135339; rs7634282; rs4135353; rs12489347; rs17036700; rs4135262; rs1175544; rs4135291; rs4135270; rs4135268; rs4135342; rs4135328; rs4135279; rs4135325; rs4135269; rs35724001; rs7639159; rs7636854; rs3105363; rs13099828; rs13099634; rs34611445; rs7636421; rs7636598; rs7616804; rs11293844; rs7639005; rs13099078; rs35125975; rs11128604; rs2307991; rs35812816; rs9282832; rs36073622; rs7623946; rs9871668; rs12632365; rs4684103; rs35995141; rs7635807; rs6784211; rs9836965; rs35520264; rs9876829; rs4135364; rs13077495; rs13076933; rs17029002; rs4135363; rs4135300; rs17425960; rs34577159; rs9880344; rs17028996; rs35138542; rs9714363; rs35204164; rs2920502; rs28936407; rs1805192; rs1800571; rs41516544; rs28763894; rs13306746; rs41415646; rs34462475; rs34797620; rs13085211; rs35324344; rs28675782; rs34047730; rs9812856; rs34861493; rs11558404; rs34251960; rs35459073; rs2972165; rs13316783; rs34091265; rs34108955; rs2347528; rs6802327; rs35658489; rs34391565; rs34034515; rs11718894; rs34727071; rs33992296; rs2921186; rs13067060; rs2197424; rs3031383; rs28469357; rs9812859; rs35649998; rs35590426; rs13090995; rs17036428; rs17029009; rs34665399; rs34694812; rs11323214; rs5846770; rs13088728; rs35004171; rs17036277; rs9860894; rs11712531; rs34096560; rs13097936; rs13082177; rs35917766; rs36001830; rs28684849; rs17425942; rs34598704; rs17036279; rs3910864; rs34915207; rs11319327; rs35408322; rs28435743; rs2972160; rs11921075; rs13095372; rs3112394; rs4438634; rs36035284; rs11450436; rs2921187; rs34758352; rs13091468; rs10620909; rs11360916; rs10665975; rs7614873; rs17029007; rs9858703; rs11321700; rs34832349; rs35958630; rs36009235; rs11712037; rs35256588; rs35816057; rs17050720; rs10212146; rs35562755; rs10212145; rs34295844; rs7650213; rs3112392; rs35763971; rs11719187; rs35248164; rs34914033; rs7627000; rs2972161; rs9282833; rs7430836; rs11718489; rs17036183; rs13082084; rs35305483; rs35986947; rs35944176; rs2972159; rs5846769; rs17036317; rs9813120; rs11293858; rs35196430; rs9824047; rs11458097; rs11394520; rs34762200; rs2920501; rs35224214; rs34258522; rs35431607; rs35830690; rs1064061; rs7641290; rs5846771; rs35240997; rs35824198; rs1984668; rs3963365; rs11712510; rs34850546; rs28783437; rs28683092; rs34001022; rs2920504; rs10619114; rs35788455; rs17036179; rs9827378; rs35586299; rs35112713; rs11456875; rs35000407; rs6787534; rs12106668; rs13091131; rs34856298; rs34132377; rs13095882; rs6795126; rs2938393; rs35403303; rs11373145; rs36052770; rs13316883; rs10587216; rs3773360; rs7612778; rs11451254; rs35474352; rs4371498; rs11324808; rs35789821; rs9837762; rs11372505; rs13071893; rs2921192; rs35942115; rs11287877; rs1152000; rs11280439; rs11337165; rs35434486; rs1797879; rs11346922; rs35190152; rs41311317; rs10540594; rs35649722; rs10049123; rs34692304; rs1699373; rs10602525; rs34493672; rs34334895; rs3821614; rs9837916; rs1797878; rs12629147; rs9843706; rs13064303; rs35491663; rs35258697; rs10643169; rs4684852; rs2938391; rs35632413; rs35218291; rs3127609; rs5846772; rs3105364; rs13095707; rs34897095; rs2938390; rs35121790; rs6147711; rs13075164; rs4684851; rs34151900; rs35880011; rs9833647; rs10614129; rs1987536; rs11427297; rs35082382; rs36025945; rs13095719; rs36121170; rs3836371; rs34898812; rs34318338; rs11914306; rs3127608; rs35948804; rs11344254; rs796289; rs11377897; rs35598149; rs10575755; rs36055981; rs11368226; rs11713869; rs10048953; rs11446342; rs1797895; rs35691895; rs41484149; rs1185785; rs11329101; rs3773357; rs3210577; rs41293379; rs28848197; rs34241217; rs7627540; rs3103310; rs4684102; rs35168570; rs41491647; rs10222537; rs1152003; rs1152004; rs1152005; rs1175545; rs1181795; rs13066537; rs13090265; rs1663813; rs17036753; rs1797877; rs2920500; rs2920503; rs2960421; rs4498025; rs4684104; rs6790976; rs709159; rs7609637; rs7616847; rs7622847; rs7643499; rs9827787; rs9831245; rs9831411; rs9833097; rs9837686; rs9868474

# Macromolecular_Interacting_Partner_13_General_References:
9065481; 8702406; 9144532; 7787419; 9356045; 8706692; 10681503; 11971969; 10882139; 9425261; 9753710; 10407229; 10394368; 10622252; 11788685

# Macromolecular_Interacting_Partner_13_References:
17032502; 17119271; 17119541; 17130474

# Macromolecular_Interacting_Partner_14_ID:
7694

# Macromolecular_Interacting_Partner_14_Name:
Peroxisome proliferator-activated receptor alpha

# Macromolecular_Interacting_Partner_14_Synonyms:
PPAR-alpha

# Macromolecular_Interacting_Partner_14_Gene_Name:
PPARA

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>Peroxisome proliferatoractivated receptor alpha
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
468

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
52226

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
6.20

# Macromolecular_Interacting_Partner_14_GO_Classification:
>>>
Function:  steroid hormone receptor activity
Function:  transcription factor activity
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_14_General_Function:
Not Available

# Macromolecular_Interacting_Partner_14_Specific_Function:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids

# Macromolecular_Interacting_Partner_14_Pathway:
Not Available

# Macromolecular_Interacting_Partner_14_Reaction:
Not Available

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_14_Signals:
None

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
307341

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
PPARA_HUMAN (Q07869)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
PPARA

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
PPARA

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:9232

# Macromolecular_Interacting_Partner_14_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>1407 bp
ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAG
AGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGGAAACATCCAAGAGATTTCGCAATCC
ATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT
CCTGGCTCAGATGGCTCGGTCATCACGGACACGCTTTCACCAGCTTCGAGCCCCTCCTCG
GTGACTTATCCTGTGGTCCCCGGCAGCGTGGACGAGTCTCCCAGTGGAGCATTGAACATC
GAATGTAGAATCTGCGGGGACAAGGCCTCAGGCTATCATTACGGAGTCCACGCGTGTGAA
GGCTGCAAGGGCTTCTTTCGGCGAACGATTCGACTCAAGCTGGTGTATGACAAGTGCGAC
CGCAGCTGCAAGATCCAGAAAAAGAACAGAAACAAATGCCAGTATTGTCGATTTCACAAG
TGCCTTTCTGTCGGGATGTCACACAACGCGATTCGTTTTGGACGAATGCCAAGATCTGAG
AAAGCAAAACTGAAAGCAGAAATTCTTACCTGTGAACATGACATAGAAGATTCTGAAACT
GCAGATCTCAAATCTCTGGCCAAGAGAATCTACGAGGCCTACTTGAAGAACTTCAACATG
AACAAGGTCAAAGCCCGGGTCATCCTCTCAGGAAAGGCCAGTAACAATCCACCTTTTGTC
ATACATGATATGGAGACACTGTGTATGGCTGAGAAGACGCTGGTGGCCAAGCTGGTGGCC
AATGGCATCCAGAACAAGGAGGTGGAGGTCCGCATCTTTCACTGCTGCCAGTGCACGTCA
GTGGAGACCGTCACGGAGCTCACGGAATTCGCCAAGGCCATCCCAGCGTTCGCAAACTTG
GACCTGAACGATCAAGTGACATTGCTAAAATACGGAGTTTATGAGGCCATATTCGCCATG
CTGTCTTCTGTGATGAACAAAGACGGGATGCTGGTAGCGTATGGAAATGGGTTTATAACT
CGTGAATTCCTAAAAAGCCTAAGGAAACCGTTCTGTGATATCATGGAACCCAAGTTTGAT
TTTGCCATGAAGTTCAATGCACTGGAACTGGATGACAGTGATATCTCCCTTTTTGTGGCT
GCTATCATTTGCTGTGGAGATCGTCCTGGCCTTCTAAACGTAGGACACATTGAAAAAATG
CAGGAGGGTATTGTACATGTGCTCAGACTCCACCTGCAGAGCAACCACCCGGACGATATC
TTTCTCTTCCCAAAACTTCTTCAAAAAATGGCAGACCTCCGGCAGCTGGTGACGGAGCAT
GCGCAGCTGGTGCAGATCATCAAGAAGACGGAGTCGGATGCTGCGCTGCACCCGCTACTG
CAGGAGATCTACAGGGACATGTACTGA

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
L02932

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_14_Locus:
22q12-q13.1|22q13.31

# Macromolecular_Interacting_Partner_14_SNPs:
rs1800206; rs1800234; rs1800204; rs1800235; rs4253773; rs135547; rs129600; rs4253681; rs4253652; rs135552; rs135539; rs135542; rs4253655; rs12330015; rs9627046; rs135538; rs4253663; rs7364220; rs4253620; rs4253698; rs4253781; rs9626729; rs4253758; rs4253699; rs4253630; rs4253682; rs4253703; rs1555208; rs4253701; rs4253622; rs4253704; rs135549; rs4253665; rs4253686; rs4253792; rs6008259; rs4253702; rs4253669; rs135550; rs135543; rs4253621; rs4253788; rs4253678; rs4253695; rs4253791; rs5769177; rs4253674; rs4253671; rs4253641; rs4253624; rs5766696; rs4253639; rs4253618; rs7286168; rs4253786; rs4253784; rs4253651; rs4253757; rs4253800; rs8138102; rs4253635; rs4253670; rs4253789; rs11704856; rs4253660; rs4253645; rs9626736; rs4253797; rs135540; rs4253638; rs4253694; rs8135690; rs4253633; rs4253627; rs4253642; rs4253696; rs4253656; rs4253706; rs4253659; rs4253672; rs4253691; rs4253667; rs9306498; rs5766698; rs4253688; rs4253623; rs4253634; rs4253801; rs1055659; rs135548; rs4253687; rs4253707; rs4253646; rs6008970; rs4253664; rs4253643; rs4253700; rs4253668; rs135555; rs4253685; rs4253640; rs6008976; rs7287085; rs4253705; rs3892755; rs4253661; rs4253626; rs4253637; rs4253658; rs4253629; rs4253782; rs4253647; rs7289836; rs4253679; rs135551; rs4253793; rs4253617; rs4253692; rs4253631; rs4253644; rs4253625; rs9306499; rs4253790; rs4253787; rs4253683; rs4253619; rs4253662; rs4253657; rs5769178; rs4253756; rs4253684; rs4253636; rs135554; rs4253785; rs4253628; rs9626737; rs4253780; rs4253654; rs4253677; rs761543; rs4253783; rs4253648; rs11704979; rs4253680; rs4253616; rs9626814; rs4253653; rs4253693; rs4253673; rs4253632; rs4253650; rs4253689; rs11913649; rs4253666; rs4823902; rs11704508; rs5769243; rs10427717; rs8135547; rs9680739; rs8139731; rs17661656; rs3747246; rs41367645; rs17661718; rs9306500; rs5766804; rs135553; rs41388244; rs9615264; rs16994933; rs41427746; rs16994915; rs6007981; rs17241878; rs10154348; rs12162684; rs11705154; rs11703495; rs135541; rs12160659; rs7287027; rs4823586; rs6009111; rs41378347; rs12169296; rs135545; rs1134224; rs10775794; rs11703746; rs135536; rs9680676; rs12169290; rs9627268; rs5769366; rs17241885; rs7288994; rs9627100; rs7289495; rs1055657; rs6009081; rs135546; rs1800246; rs5767743; rs4253762; rs4253778; rs4253690; rs4823613; rs4253769; rs4253751; rs6008197; rs6519979; rs4253761; rs4253747; rs4253730; rs4253775; rs4253713; rs4253719; rs4253750; rs4253764; rs4253765; rs4253776; rs4253729; rs4253709; rs4253712; rs4253760; rs4253728; rs11090819; rs4253737; rs4253770; rs4253777; rs2336904; rs4253711; rs4253754; rs4253798; rs4253748; rs4253727; rs4253723; rs4253710; rs4253714; rs6008160; rs4253708; rs4253718; rs4253774; rs4253722; rs4253767; rs4253732; rs5766741; rs4253726; rs4253799; rs5767700; rs7364297; rs4253736; rs4253794; rs4253752; rs4253731; rs4253766; rs4253721; rs4253717; rs4253742; rs4253744; rs4253697; rs4253771; rs4253746; rs4253725; rs4253739; rs4253720; rs4253738; rs4253755; rs1800245; rs4253795; rs4253716; rs4253735; rs4253734; rs5766743; rs4253779; rs4253741; rs4253753; rs6007662; rs4253768; rs4253743; rs4253745; rs4253772; rs4253763; rs4253724; rs4253759; rs4253733; rs4253715; rs8139794; rs4253740; rs4253749; rs8139663; rs41397552; rs11090791; rs11702902; rs11090817; rs6008123; rs7291727; rs5769175; rs5767636; rs9615238; rs5767560; rs5766734; rs6008126; rs5767633; rs11090818; rs8140236; rs12170204; rs9626730; rs11705483; rs11913971; rs7292459; rs5767634; rs4823477; rs6413511; rs1800243; rs1800242; rs9615759; rs1042311; rs5767686; rs1800236; rs12167302; rs9615163; rs41418950; rs34666721; rs5769287; rs35328780; rs7292112; rs11383159; rs7364140; rs5769365; rs34148860; rs5845740; rs35404482; rs35249750; rs41403648; rs35988564; rs6009112; rs5845739; rs36096470; rs41532849; rs881740; rs9615524; rs7286871; rs12484245; rs13053358; rs11538240; rs35966870; rs34896841; rs35838035; rs10643430; rs13053293; rs5767779; rs12171095; rs41479847; rs28772875; rs6009058; rs4592961; rs9627007; rs34109484; rs12159525; rs12170381; rs5845741; rs135544; rs41406451; rs35398060; rs28369325; rs5769129; rs12160049; rs34857047; rs12159225; rs6008042; rs7364165; rs10561065; rs7289761; rs5769184; rs9626764; rs12159821; rs5766682; rs41362646; rs41465647; rs3840962; rs5769088; rs41371446; rs2238833; rs4823487; rs9626756; rs7290774; rs41368348; rs5769276; rs34001104; rs35552991; rs28716636; rs13055301; rs5767424; rs12167354; rs1055658; rs41477146; rs5769364; rs36096495; rs5769356; rs35281820; rs35038216; rs41371949; rs5769142; rs11703765; rs35808855; rs6009014; rs41489145; rs9626751; rs135537; rs41355347; rs34437230; rs9615534; rs6007965; rs12159097; rs9615784; rs11344804; rs5769219; rs9615523; rs16994976; rs9626716; rs28895660; rs41329344; rs35345592; rs41489148; rs1800244; rs13054427; rs11912612; rs11703766; rs36124248; rs12166902; rs6008974; rs13055320; rs5769112; rs41332048; rs12169623; rs5769206; rs36074474; rs35436527; rs13056945; rs8139926; rs9627217; rs6008089; rs10570542; rs34977841; rs11325484; rs35637220; rs9615694; rs17847852; rs4365564; rs5767667; rs8135879; rs12166737; rs5767617; rs5766714; rs9626745; rs2336905; rs6008193; rs9615695; rs7290878; rs1973929; rs28875881; rs41526048; rs35528985; rs12168403; rs34108706; rs34716781; rs9626811; rs41461946; rs12168939; rs6008129; rs34902389; rs12166868; rs10563623; rs10427969; rs8141725; rs4365565; rs5767650; rs34142992; rs9627047; rs7290473; rs5767708; rs6008149; rs34052175; rs11703314; rs6008161; rs10593071; rs35418581; rs11445888; rs35658961; rs34873839; rs10658167; rs41497148; rs35027666; rs6008116; rs34774436; rs11270575; rs34036883; rs35700219; rs6008093; rs6007639; rs13057868; rs28669215; rs11332243; rs41343752; rs28508200; rs2283673; rs5767618; rs28786744; rs10591809; rs12170430; rs12168830; rs12167549; rs34858419; rs13058348; rs8141442; rs6008191; rs6008096; rs5767763; rs35145000; rs28584795; rs6007673; rs7286742; rs12168937; rs28828403; rs35615646; rs34406573; rs13058552; rs6008130; rs12166556; rs13056831; rs9626742; rs34363509; rs9615487; rs5767320; rs34775146; rs9626709; rs12157295; rs10154668; rs1053332; rs11705226; rs12106599; rs12159251; rs135556; rs135557; rs135559; rs135560; rs135561; rs135562; rs14842; rs14843; rs16995065; rs16995067; rs16995069; rs5767842; rs6008923; rs717926; rs7284616; rs7289611; rs7291028; rs9626816; rs9626823; rs9627278; rs9627280; rs9627281; rs9627287

# Macromolecular_Interacting_Partner_14_General_References:
7684926; 7981125; 8993548; 10591208; 9238002; 10681503

# Macromolecular_Interacting_Partner_14_References:
17119268

# Macromolecular_Interacting_Partner_15_ID:
7738

# Macromolecular_Interacting_Partner_15_Name:
Appetite-regulating hormone precursor

# Macromolecular_Interacting_Partner_15_Synonyms:
Growth hormone secretagogue; Growth hormone-releasing peptide; Motilin-related peptide; M46 protein[Contains: Ghrelin-27; Ghrelin-28; Ghrelin; Obestatin]

# Macromolecular_Interacting_Partner_15_Gene_Name:
GHRL

# Macromolecular_Interacting_Partner_15_Protein_Sequence:
>Appetiteregulating hormone precursor
MPSPGTVCSLLLLGMLWLDLAMAGSSFLSPEHQRVQQRKESKKPPAKLQPRALAGWLRPE
DGGQAEGAEDELEVRFNAPFDVGIKLSGVQYQQHSQALGKFLQDILWEEAKEAPADK

# Macromolecular_Interacting_Partner_15_Number_of_Residues:
117

# Macromolecular_Interacting_Partner_15_Molecular_Weight:
12911

# Macromolecular_Interacting_Partner_15_Theoretical_pI:
5.18

# Macromolecular_Interacting_Partner_15_GO_Classification:
>>>
Function:  growth hormone-releasing hormone activity
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_15_General_Function:
Not Available

# Macromolecular_Interacting_Partner_15_Specific_Function:
Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility

# Macromolecular_Interacting_Partner_15_Pathway:
Not Available

# Macromolecular_Interacting_Partner_15_Reaction:
Not Available

# Macromolecular_Interacting_Partner_15_Pfam_Domain_Function:
PF04643:Motilin_assoc;
PF04644:Motilin_ghrelin

# Macromolecular_Interacting_Partner_15_Signals:
1-23

# Macromolecular_Interacting_Partner_15_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_15_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_15_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_15_GenBank_ID_Protein:
6691572

# Macromolecular_Interacting_Partner_15_SwissProt_ID:
GHRL_HUMAN (Q9UBU3)

# Macromolecular_Interacting_Partner_15_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_15_Genecard_id:
GHRL

# Macromolecular_Interacting_Partner_15_Geneatlas_id:
GHRL

# Macromolecular_Interacting_Partner_15_hgnc_id:
HGNC:18129

# Macromolecular_Interacting_Partner_15_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_15_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_15_Gene_Sequence:
>354 bp
ATGCCCTCCCCAGGGACCGTCTGCAGCCTCCTGCTCCTCGGCATGCTCTGGCTGGACTTG
GCCATGGCAGGCTCCAGCTTCCTGAGCCCTGAACACCAGAGAGTCCAGCAGAGAAAGGAG
TCGAAGAAGCCACCAGCCAAGCTGCAGCCCCGAGCTCTAGCAGGCTGGCTCCGCCCGGAA
GATGGAGGTCAAGCAGAAGGGGCAGAGGATGAACTGGAAGTCCGGTTCAACGCCCCCTTT
GATGTTGGAATCAAGCTGTCAGGGGTTCAGTACCAGCAGCACAGCCAGGCCCTGGGGAAG
TTTCTTCAGGACATCCTCTGGGAAGAGGCCAAAGAGGCCCCAGCCGACAAGTGA

# Macromolecular_Interacting_Partner_15_GenBank_ID_Gene:
AB029434

# Macromolecular_Interacting_Partner_15_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_15_Locus:
3p26-p25

# Macromolecular_Interacting_Partner_15_SNPs:
rs4684677; rs696217; rs26802; rs35680; rs2075356; rs35682; rs35679; rs35681; rs42451; rs35683; rs11923293; rs11923313; rs9866514; rs27647; rs26312; rs27498; rs26311; rs4684678; rs3755777; rs34911341; rs35860352; rs36023991; rs34065382; rs9853290; rs34617791; rs35402980; rs9853024; rs35597000; rs697228; rs4988507; rs34186135; rs4988506; rs10285; rs10490815; rs10490816; rs1063429; rs11711287; rs11716841; rs11718213; rs12630739; rs149162; rs1617161; rs1629816; rs17032621; rs171336; rs171407; rs1803475; rs2072578; rs2075355; rs242728; rs242729; rs2619507; rs35684; rs3732950; rs3774202; rs3846106; rs40608; rs4684675; rs4684679; rs514658; rs582868; rs6809341; rs703916

# Macromolecular_Interacting_Partner_15_General_References:
10604470; 10930375; 12975309; 11306336

# Macromolecular_Interacting_Partner_15_References:
17026536; 17061019; 17130496

# Macromolecular_Interacting_Partner_16_ID:
7844

# Macromolecular_Interacting_Partner_16_Name:
Insulin-like growth factor IA precursor

# Macromolecular_Interacting_Partner_16_Synonyms:
IGF-IA; Somatomedin C; Mechano growth factor; MGF

# Macromolecular_Interacting_Partner_16_Gene_Name:
IGF1

# Macromolecular_Interacting_Partner_16_Protein_Sequence:
>Insulinlike growth factor IA precursor
MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD
ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS
VRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM

# Macromolecular_Interacting_Partner_16_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_16_Molecular_Weight:
17026

# Macromolecular_Interacting_Partner_16_Theoretical_pI:
9.40

# Macromolecular_Interacting_Partner_16_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
Function:  neuropeptide hormone activity
Function:  prothoracicotrophic hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_16_General_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Specific_Function:
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity

# Macromolecular_Interacting_Partner_16_Pathway:
Not Available

# Macromolecular_Interacting_Partner_16_Reaction:
Not Available

# Macromolecular_Interacting_Partner_16_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_16_Signals:
1-21

# Macromolecular_Interacting_Partner_16_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_16_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_16_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_16_GenBank_ID_Protein:
183110

# Macromolecular_Interacting_Partner_16_SwissProt_ID:
IGF1A_HUMAN (P01343)

# Macromolecular_Interacting_Partner_16_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_16_Genecard_id:
IGF1

# Macromolecular_Interacting_Partner_16_Geneatlas_id:
IGF1

# Macromolecular_Interacting_Partner_16_hgnc_id:
HGNC:5464

# Macromolecular_Interacting_Partner_16_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_16_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_16_Gene_Sequence:
>462 bp
ATGGGAAAAATCAGCAGTCTTCCAACCCAATTATTTAAGTGCTGCTTTTGTGATTTCTTG
AAGGTGAAGATGCACACCATGTCCTCCTCGCATCTCTTCTACCTGGCGCTGTGCCTGCTC
ACCTTCACCAGCTCTGCCACGGCTGGACCGGAGACGCTCTGCGGGGCTGAGCTGGTGGAT
GCTCTTCAGTTCGTGTGTGGAGACAGGGGCTTTTATTTCAACAAGCCCACAGGGTATGGC
TCCAGCAGTCGGAGGGCGCCTCAGACAGGCATCGTGGATGAGTGCTGCTTCCGGAGCTGT
GATCTAAGGAGGCTGGAGATGTATTGCGCACCCCTCAAGCCTGCCAAGTCAGCTCGCTCT
GTCCGTGCCCAGCGCCACACCGACATGCCCAAGACCCAGAAGGAAGTACATTTGAAGAAC
GCAAGTAGAGGGAGTGCAGGAAACAAGAACTACAGGATGTAG

# Macromolecular_Interacting_Partner_16_GenBank_ID_Gene:
M14156

# Macromolecular_Interacting_Partner_16_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_16_Locus:
12q22-q23

# Macromolecular_Interacting_Partner_16_SNPs:
rs17884626; rs3729846; rs6220; rs6219; rs5742714; rs6214; rs6216; rs5742707; rs6217; rs6222; rs3730192; rs3730205; rs5742711; rs3730204; rs5742705; rs6221; rs5742713; rs5742715; rs3730189; rs5742706; rs1063599; rs6218; rs5742700; rs6215; rs35528193; rs17881987; rs3209674; rs6212; rs3730201; rs3730190; rs5742704; rs1140655; rs17879349; rs5031032; rs978458; rs2373721; rs1019731; rs2195240; rs2288378; rs2195239; rs5742629; rs11111274; rs5742657; rs2033178; rs7314527; rs10860869; rs4764696; rs10778176; rs9989002; rs4764883; rs12310428; rs5009837; rs5742659; rs9308315; rs972936; rs5742683; rs4764886; rs10735380; rs4764887; rs7136446; rs5742632; rs7956547; rs5742692; rs17727519; rs6213; rs17880975; rs17882264; rs10047577; rs2072592; rs17879892; rs5742627; rs5742634; rs6539035; rs10860865; rs5742694; rs17032565; rs5742620; rs5742644; rs12821878; rs11831436; rs7957559; rs5742696; rs10745942; rs17032634; rs5742682; rs1520221; rs17727841; rs11829586; rs1549593; rs2195242; rs10860867; rs9651925; rs17884734; rs17884998; rs5742658; rs4764698; rs11111265; rs5742665; rs11831702; rs12305089; rs12423791; rs5742614; rs5742639; rs5742643; rs5742690; rs17885092; rs12299353; rs2162679; rs5742695; rs5742653; rs5742623; rs17032623; rs5742615; rs11837195; rs11111272; rs5742668; rs5742626; rs5742624; rs5742678; rs5742637; rs11111267; rs1520220; rs7132915; rs5742667; rs5742652; rs5742669; rs5742618; rs10778174; rs4764697; rs28682289; rs5742671; rs11111266; rs4764699; rs5742655; rs5742638; rs10778175; rs5742666; rs5742617; rs5742663; rs12833855; rs5742689; rs5742622; rs17885209; rs7300373; rs5742654; rs5742645; rs7971494; rs5742636; rs10745940; rs17796225; rs5742661; rs35996361; rs17886202; rs5742656; rs5742686; rs5742670; rs2373722; rs35524121; rs17882461; rs11111269; rs35626892; rs11111262; rs5742647; rs10860864; rs17882373; rs5742664; rs12313279; rs17884900; rs5742625; rs17878658; rs7296464; rs17879380; rs12426645; rs5742635; rs5742688; rs5742628; rs6539036; rs5742672; rs34300540; rs5742649; rs4764885; rs35897406; rs35349902; rs35209973; rs5742630; rs17882108; rs17878845; rs17885477; rs1520222; rs17886416; rs17881922; rs35437018; rs17879867; rs12316064; rs5742633; rs34291100; rs34311929; rs5742660; rs5742641; rs17878318; rs5742648; rs17884646; rs11608757; rs5742621; rs5742684; rs12425939; rs4764884; rs10860866; rs17032577; rs17878342; rs35767; rs5742722; rs5742723; rs2946834; rs11829707; rs5742720; rs5742612; rs11829693; rs2288377; rs5742716; rs3730195; rs3730193; rs35365615; rs5742702; rs3730211; rs3730224; rs5742712; rs3730210; rs4479044; rs3730207; rs5800508; rs34632512; rs17884961; rs5742698; rs3730206; rs3730203; rs35306040; rs35234844; rs3730188; rs3730226; rs17885397; rs5742703; rs5742701; rs2114911; rs3730218; rs5742708; rs3730221; rs28399924; rs35770817; rs1142050; rs3730200; rs35042457; rs1063600; rs14970; rs34621369; rs5742709; rs3032446; rs3730209; rs3730191; rs5742613; rs3730223; rs17847185; rs5742710; rs3730212; rs3730208; rs17847188; rs35359199; rs5800507; rs17886337; rs35249557; rs12817059; rs9282710; rs34903472; rs5742693; rs12299690; rs34647656; rs5742675; rs12810139; rs10745941; rs2373723; rs17879585; rs17880891; rs12320356; rs35140968; rs5800510; rs17879693; rs17882696; rs35437431; rs35174508; rs5742687; rs17885230; rs11608743; rs12368271; rs17882221; rs2373724; rs17886520; rs35775928; rs5742619; rs10860863; rs17885564; rs5742676; rs5742677; rs11421600; rs34805296; rs12816379; rs11608742; rs11111273; rs17879010; rs17886798; rs17882149; rs34599859; rs12817072; rs3032454; rs34813772; rs10860868; rs17879390; rs11111268; rs17885210; rs9282711; rs17886237; rs35222135; rs17878871; rs3729847; rs10557735; rs12320358; rs12819048; rs17878637; rs34545292; rs17882016; rs17878716; rs10614489; rs34568432; rs5742650; rs11111279; rs17881804; rs17878620; rs5742616; rs35813377; rs35403470; rs5742640; rs5742673; rs35865277; rs17879664; rs10685119; rs5742680; rs11111263; rs12314338; rs17878397; rs11111271; rs17880004; rs5742681; rs5742646; rs35004383; rs11111278; rs34817710; rs36103805; rs11111270; rs5742651; rs17881582; rs17885105; rs12816545; rs17882697; rs5742674; rs35123842; rs10161018; rs17882126; rs35993329; rs5742697; rs764911; rs11111277; rs35635523; rs12809983; rs5742631; rs1015693; rs17878818; rs12370356; rs11111276; rs35660465; rs7297946; rs11111281; rs11305762; rs34097393; rs34199594; rs5742662; rs17881697; rs36047405; rs36123817; rs4764882; rs17878303; rs36005419; rs17886265; rs17728444; rs12319588; rs17884880; rs34918171; rs11111264; rs35433913; rs5800512; rs17885262; rs17879785; rs17879563; rs17883650; rs34618338; rs34085295; rs34241965; rs17883689; rs34212937; rs17882244; rs17887104; rs34938746; rs35261849; rs12816586; rs17885578; rs17882564; rs17884984; rs17879080; rs17879837; rs12820619; rs11111280; rs12229818; rs17885158; rs5742691; rs34800889; rs12821533; rs11837097; rs5742679; rs17882237; rs12301183; rs34432139; rs17886964; rs34588740; rs5742685; rs10542027; rs35407198; rs5742642; rs17882333; rs10592539; rs5800511; rs17885342; rs35384466; rs3033405; rs12830260; rs2217241; rs3033407; rs17879774; rs35806302; rs17882374; rs5742717; rs10665874; rs5742719; rs5800513; rs7487728; rs5742718; rs17884864; rs5742721; rs10860860; rs10860861; rs10860862; rs11111259; rs11111260; rs11111261; rs11111282; rs11831864; rs12301163; rs12301559; rs12579077; rs12579108; rs1457601; rs17032483; rs17032487; rs17032648; rs2373720; rs2946831; rs2971575; rs2971577; rs35765; rs35766; rs7316439; rs7980083; rs855201; rs9919733

# Macromolecular_Interacting_Partner_16_General_References:
2937782; 6358902; 2935423; 3002851; 2018498; 1372070; 6382022; 632300; 6189745; 2036417; 1319992; 3242681; 8857020

# Macromolecular_Interacting_Partner_16_References:
17043386; 17047390

# Macromolecular_Interacting_Partner_17_ID:
8410

# Macromolecular_Interacting_Partner_17_Name:
Sodium/glucose cotransporter 1

# Macromolecular_Interacting_Partner_17_Synonyms:
Na(+/glucose cotransporter 1; High affinity sodium-glucose cotransporter

# Macromolecular_Interacting_Partner_17_Gene_Name:
SLC5A1

# Macromolecular_Interacting_Partner_17_Protein_Sequence:
>Sodium/glucose cotransporter 1
MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFL
AGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIY
IKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLA
IFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAI
PTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQR
CLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVG
CTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEK
ELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRV
NEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFIT
IVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKG
IFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCH
AYFA

# Macromolecular_Interacting_Partner_17_Number_of_Residues:
664

# Macromolecular_Interacting_Partner_17_Molecular_Weight:
73499

# Macromolecular_Interacting_Partner_17_Theoretical_pI:
7.74

# Macromolecular_Interacting_Partner_17_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_17_General_Function:
Not Available

# Macromolecular_Interacting_Partner_17_Specific_Function:
Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules

# Macromolecular_Interacting_Partner_17_Pathway:
Not Available

# Macromolecular_Interacting_Partner_17_Reaction:
Not Available

# Macromolecular_Interacting_Partner_17_Pfam_Domain_Function:
PF00474:SSF

# Macromolecular_Interacting_Partner_17_Signals:
None

# Macromolecular_Interacting_Partner_17_Transmembrane_Regions:
29-49
65-85
106-126
143-163
179-201
209-229
278-298
314-334
381-401
424-444
456-476
485-505
527-547
644-664

# Macromolecular_Interacting_Partner_17_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_17_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_17_GenBank_ID_Protein:
338055

# Macromolecular_Interacting_Partner_17_SwissProt_ID:
SC5A1_HUMAN (P13866)

# Macromolecular_Interacting_Partner_17_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_17_Genecard_id:
SLC5A1

# Macromolecular_Interacting_Partner_17_Geneatlas_id:
SLC5A1

# Macromolecular_Interacting_Partner_17_hgnc_id:
HGNC:11036

# Macromolecular_Interacting_Partner_17_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_17_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_17_Gene_Sequence:
>1995 bp
ATGGACAGTAGCACCTGGAGCCCCAAGACCACCGCGGTCACCCGGCCTGTTGAGACCCAC
GAGCTCATTCGCAATGCAGCCGATATCTCCATCATCGTTATCTACTTCGTGGTAGTGATG
GCCGTCGGACTGTGGGCTATGTTTTCCACCAATCGTGGGACTGTTGGAGGCTTCTTCCTG
GCAGGCCGAAGTATGGTGTGGTGGCCGATTGGAGCCTCCCTCTTTGCTAGTAACATTGGA
AGTGGCCACTTTGTGGGGCTGGCCGGGACTGGGGCAGCTTCAGGCATCGCCATTGGAGGC
TTTGAATGGAATGCCCTGGTTTTGGTGGTTGTGCTGGGCTGGCTGTTTGTCCCCATCTAT
ATTAAGGCTGGGGTGGTGACAATGCCAGAGTACCTGAGGAAGCGGTTTGGAGGCCAGCGG
ATCCAGGTCTACCTTTCCCTTCTGTCCCTGCTGCTCTACATTTTCACCAAGATCTCGGCA
GACATCTTCTCGGGGGCCATATTCATCAATCTGGCCTTAGGCCTGAATCTGTATTTAGCC
ATCTTTCTCTTATTGGCAATCACTGCCCTTTACACAATTACAGGGGGCCTGGCGGCGGTG
ATTTACACGGACACCTTGCAGACGGTGATCATGCTGGTGGGGTCTTTAATCCTGACTGGG
TTTGCTTTTCACGAAGTGGGAGGCTATGACGCCTTCATGGAAAAGTACATGAAAGCCATT
CCAACCATAGTGTCTGATGGCAACACCACCTTTCAGGAAAAATGCTACACTCCAAGGGCC
GACTCCTTCCACATCTTCCGAGATCCCCTCACGGGAGACCTCCCATGGCCTGGGTTCATC
TTTGGGATGTCCATCCTTACCTTGTGGTACTGGTGCACAGATCAGGTCATTGTGCAGCGC
TGCCTCTCAGCCAAGAATATGTCTCACGTGAAGGGTGGCTGCATCCTGTGTGGGTATCTA
AAGCTGATGCCCATGTTCATCATGGTGATGCCAGGAATGATCAGCCGCATTCTGTACACA
GAAAAAATTGCCTGTGTCGTCCCTTCAGAATGTGAGAAATATTGCGGTACCAAGGTTGGC
TGTACCAACATCGCCTATCCAACCTTAGTGGTGGAGCTCATGCCCAATGGACTGCGAGGC
CTGATGCTATCAGTCATGCTGGCCTCCCTCATGAGCTCCCTGACCTCCATCTTCAACAGC
GCCAGCACCCTCTTCACCATGGACATCTACGCCAAGGTCCGCAAGAGAGCATCTGAGAAA
GAGCTCATGATTGCCGGAAGGTTGTTTATCCTGGTGCTGATTGGCATCAGCATCGCCTGG
GTGCCCATTGTGCAGTCAGCACAAAGTGGGCAACTCTTCGATTACATCCAGTCCATCACC
AGTTACTTGGGACCACCCATTGCGGCTGTCTTCCTGCTTGCTATTTTCTGGAAGAGAGTC
AATGAGCCAGGAGCCTTTTGGGGACTGATCCTAGGACTTCTGATTGGGATTTCACGTATG
ATTACTGAGTTTGCTTATGGAACCGGGAGCTGCATGGAGCCCAGCAACTGTCCCACGATT
ATCTGTGGGGTGCACTACTTGTACTTTGCCATTATCCTCTTCGCCATTTCTTTCATCACC
ATCGTGGTCATCTCCCTCCTCACCAAACCCATTCCGGATGTGCATCTCTACCGTCTGTGT
TGGAGCCTGCGCAACAGCAAAGAGGAGCGTATTGACCTGGATGCGGAAGAGGAGAACATC
CAAGAAGGCCCTAAGGAGACCATTGAAATAGAAACACAAGTTCCTGAGAAGAAAAAAGGA
ATCTTCAGGAGAGCCTATGACCTATTTTGTGGGCTAGAGCAGCACGGTGCACCCAAGATG
ACTGAGGAAGAGGAGAAAGCCATGAAGATGAAGATGACGGACACCTCTGAGAAGCCTTTG
TGGAGGACAGTGTTGAACGTCAATGGCATCATCCTGGTGACCGTGGCTGTCTTTTGCCAT
GCATATTTTGCCTGA

# Macromolecular_Interacting_Partner_17_GenBank_ID_Gene:
M24847

# Macromolecular_Interacting_Partner_17_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_17_Locus:
22q13.1|22q12.3

# Macromolecular_Interacting_Partner_17_SNPs:
rs17683430; rs17683011; rs17683704; rs17683448; rs130405; rs5998233; rs135110; rs135023; rs734091; rs5998221; rs93108; rs130264; rs739009; rs5994463; rs5998228; rs5998225; rs130266; rs9606899; rs4821037; rs10483163; rs130407; rs135111; rs16989855; rs3752454; rs8139891; rs1547411; rs733907; rs4821031; rs9609420; rs17683310; rs2899173; rs5998222; rs7287435; rs1807727; rs9609421; rs5753853; rs16989809; rs734092; rs5753861; rs11913162; rs1475997; rs5998232; rs5998234; rs2413063; rs11912545; rs16989807; rs12166759; rs17745316; rs9606900; rs130406; rs2899174; rs12166345; rs2013683; rs16989842; rs743764; rs16989869; rs17683471; rs11703935; rs34830043; rs4821027; rs13057765; rs743763; rs16989845; rs11089534; rs1076905; rs2267175; rs1475996; rs17745543; rs733908; rs11703404; rs7286193; rs16989871; rs11703358; rs4821029; rs9606901; rs11913032; rs12158314; rs7284975; rs7285895; rs8138459; rs5998231; rs9609425; rs1076906; rs1056444; rs7291826; rs16989883; rs738993; rs2267173; rs35327506; rs1042566; rs34155280; rs5753863; rs35329884; rs5998230; rs130403; rs1076023; rs35013535; rs28470789; rs9619246; rs2413068; rs13056988; rs34819664; rs9606902; rs9609422; rs9621384; rs9606903; rs12159803; rs34248166; rs5998220; rs28733797; rs10677798; rs35804657; rs16989876; rs28619247; rs34035929; rs8140300; rs130267; rs28865618; rs4821030; rs2413065; rs13055656; rs35611924; rs28396666; rs9619248; rs35167706; rs5753864; rs34362494; rs4289286; rs11704400; rs11089533; rs35964250; rs4820068; rs9647305; rs28705324; rs10676021; rs9609417; rs2105866; rs9609423; rs12159428; rs13057863; rs34844950; rs5998236; rs28532565; rs12158169; rs2013684; rs34746407; rs11365344; rs28590200; rs7287793; rs12170981; rs5844962; rs5753855; rs34194550; rs2413064; rs28758489; rs13055475; rs35930984; rs11089532; rs34926213; rs28637843; rs4821028; rs35684991; rs9606904; rs34835092; rs28739501; rs28625942; rs2413067; rs12159340; rs34829582; rs131881; rs5998224; rs5998223; rs3069155; rs5749354; rs13053700; rs9609424; rs5753854; rs9609418; rs35865118; rs34522498; rs35671020; rs7289940; rs5753865; rs131880; rs28631458; rs16989863; rs10572968; rs35771891; rs2187731; rs130263; rs2413066; rs28888387; rs16989834; rs130265; rs34428161; rs5753858; rs28485900; rs10572967; rs34960379; rs135022; rs3069158; rs9609415; rs130404; rs36048736; rs5753866; rs5749352; rs34841895; rs9621383; rs35994722; rs9609419; rs10538729; rs28407831; rs35843263; rs35309167; rs34337503; rs8135210; rs35324029; rs28845289; rs12166995; rs5749353; rs2187798; rs28709492; rs34210441; rs36058777; rs35772243; rs4821036; rs36207934; rs5998219; rs2267174; rs36111134; rs2899172; rs5844961; rs12159751; rs130262; rs17683864; rs2187730; rs2413069; rs33915456; rs33954397; rs33973317; rs33985344; rs4820067; rs5753868; rs5994464; rs5998217; rs5998218; rs5998237; rs5998239; rs5998241; rs8140335; rs9606905; rs9609427; rs9621386; rs9621388; rs9621389

# Macromolecular_Interacting_Partner_17_General_References:
2490366; 8195156; 10591208; 8567640; 2008213; 10036327; 11406349

# Macromolecular_Interacting_Partner_17_References:
17130520

# Macromolecular_Interacting_Partner_18_ID:
8011

# Macromolecular_Interacting_Partner_18_Name:
Kit ligand precursor

# Macromolecular_Interacting_Partner_18_Synonyms:
C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF

# Macromolecular_Interacting_Partner_18_Gene_Name:
KITLG

# Macromolecular_Interacting_Partner_18_Protein_Sequence:
>Kit ligand precursor
MKKTQTWILTCIYLQLLLFNPLVKTEGICRNRVTNNVKDVTKLVANLPKDYMITLKYVPG
MDVLPSHCWISEMVVQLSDSLTDLLDKFSNISEGLSNYSIIDKLVNIVDDLVECVKENSS
KDLKKSFKSPEPRLFTPEEFFRIFNRSIDAFKDFVVASETSDCVVSSTLSPEKDSRVSVT
KPFMLPPVAASSLRNDSSSSNRKAKNPPGDSSLHWAAMALPALFSLIIGFAFGALYWKKR
QPSLTRAVENIQINEEDNEISMLQEKEREFQEV

# Macromolecular_Interacting_Partner_18_Number_of_Residues:
273

# Macromolecular_Interacting_Partner_18_Molecular_Weight:
30899

# Macromolecular_Interacting_Partner_18_Theoretical_pI:
5.92

# Macromolecular_Interacting_Partner_18_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  stem cell factor receptor binding
 ||
>>>
Process:  cellular process
Process:  cell adhesion
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_18_General_Function:
Not Available

# Macromolecular_Interacting_Partner_18_Specific_Function:
Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins

# Macromolecular_Interacting_Partner_18_Pathway:
Not Available

# Macromolecular_Interacting_Partner_18_Reaction:
Not Available

# Macromolecular_Interacting_Partner_18_Pfam_Domain_Function:
PF02404:SCF

# Macromolecular_Interacting_Partner_18_Signals:
1-25

# Macromolecular_Interacting_Partner_18_Transmembrane_Regions:
215-237

# Macromolecular_Interacting_Partner_18_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_18_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_18_GenBank_ID_Protein:
337934

# Macromolecular_Interacting_Partner_18_SwissProt_ID:
SCF_HUMAN (P21583)

# Macromolecular_Interacting_Partner_18_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_18_Genecard_id:
KITLG

# Macromolecular_Interacting_Partner_18_Geneatlas_id:
KITLG

# Macromolecular_Interacting_Partner_18_hgnc_id:
HGNC:6343

# Macromolecular_Interacting_Partner_18_PDB_ID:
1SCF

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_18_Subcellular_Location:
Isoform 1:Cell membrane; single-pass type I membrane protein. Isoform 2:Cell membrane; single-pass type I membrane protein (By similarity). Processed isoform 1:Secreted protein. Note=Also exists as a secreted soluble form (isoform 1 only) (By similarity)

# Macromolecular_Interacting_Partner_18_Gene_Sequence:
>822 bp
ATGAAGAAGACACAAACTTGGATTCTCACTTGCATTTATCTTCAGCTGCTCCTATTTAAT
CCTCTCGTCAAAACTGAAGGGATCTGCAGGAATCGTGTGACTAATAATGTAAAAGACGTC
ACTAAATTGGTGGCAAATCTTCCAAAAGACTACATGATAACCCTCAAATATGTCCCCGGG
ATGGATGTTTTGCCAAGTCATTGTTGGATAAGCGAGATGGTAGTACAATTGTCAGACAGC
TTGACTGATCTTCTGGACAAGTTTTCAAATATTTCTGAAGGCTTGAGTAATTATTCCATC
ATAGACAAACTTGTGAATATAGTCGATGACCTTGTGGAGTGCGTCAAAGAAAACTCATCT
AAGGATCTAAAAAAATCATTCAAGAGCCCAGAACCCAGGCTCTTTACTCCTGAAGAATTC
TTTAGAATTTTTAATAGATCCATTGATGCCTTCAAGGACTTTGTAGTGGCATCTGAAACT
AGTGATTGTGTGGTTTCTTCAACATTAAGTCCTGAGAAAGATTCCAGAGTCAGTGTCACA
AAACCATTTATGTTACCCCCTGTTGCAGCCAGCTCCCTTAGGAATGACAGCAGTAGCAGT
AATAGGAAGGCCAAAAATCCCCCTGGAGACTCCAGCCTACACTGGGCAGCCATGGCATTG
CCAGCATTGTTTTCTCTTATAATTGGCTTTGCTTTTGGAGCCTTATACTGGAAGAAGAGA
CAGCCAAGTCTTACAAGGGCAGTTGAAAATATACAAATTAATGAAGAGGATAATGAGATA
AGTATGTTGCAAGAGAAAGAGAGAGAGTTTCAAGAAGTGTAA

# Macromolecular_Interacting_Partner_18_GenBank_ID_Gene:
M59964

# Macromolecular_Interacting_Partner_18_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_18_Locus:
12q22

# Macromolecular_Interacting_Partner_18_SNPs:
rs41283112; rs3741457; rs17015782; rs1907699; rs995030; rs995029; rs906639; rs1388789; rs4842625; rs12344; rs1061981; rs11104908; rs11104905; rs1508594; rs1873680; rs11104907; rs11104906; rs17015901; rs17423825; rs11104904; rs12424567; rs1022034; rs1703081; rs1355062; rs1907703; rs7953414; rs1000788; rs1492347; rs1472898; rs2407206; rs1632677; rs3782180; rs1466691; rs1907702; rs11104925; rs7313352; rs10506953; rs2407205; rs3782176; rs4590952; rs7964695; rs11104922; rs11104923; rs1873681; rs4842632; rs11104911; rs3782181; rs2046971; rs3782170; rs7135958; rs3782174; rs1492350; rs7954414; rs7972397; rs6538154; rs11104940; rs3782179; rs10506955; rs7312974; rs3907470; rs1492354; rs2291557; rs906638; rs1472899; rs1492351; rs10858757; rs4474514; rs10506954; rs11104952; rs4842634; rs7298765; rs3782172; rs11104921; rs10506957; rs4842627; rs11104930; rs11835671; rs7969188; rs1629844; rs11104941; rs4842633; rs11104934; rs6538155; rs11610915; rs10777129; rs3782171; rs2407201; rs10506956; rs2046970; rs4284478; rs11104935; rs7297424; rs11104932; rs11104915; rs4842476; rs906637; rs1508596; rs12366295; rs10777131; rs1466692; rs10858758; rs3782178; rs10777125; rs4842630; rs11104913; rs11104942; rs10777130; rs10858760; rs11104938; rs17424366; rs1798010; rs1624014; rs11832562; rs10858753; rs12146799; rs4842631; rs10858759; rs11104933; rs11104947; rs10777126; rs12370494; rs11104939; rs10160879; rs17015899; rs1703083; rs2662060; rs1182760; rs4842475; rs11104929; rs4842628; rs1162372; rs1492356; rs12369778; rs10777127; rs11104945; rs11830019; rs11104931; rs1492348; rs4842629; rs2220695; rs3782175; rs7954809; rs11835565; rs11104920; rs7965365; rs2407204; rs4842626; rs11104937; rs11832155; rs11104924; rs4104478; rs11104948; rs11104914; rs11836241; rs11837051; rs4638377; rs11104928; rs2407203; rs17339927; rs1352947; rs11836316; rs7953218; rs1798011; rs12304776; rs4842477; rs17424193; rs869408; rs41416044; rs41300048; rs35191199; rs41300056; rs41306439; rs41303009; rs17015780; rs41300064; rs12814072; rs41300052; rs41306435; rs12369230; rs7484902; rs41303011; rs34504800; rs35000652; rs41311955; rs41306956; rs1508597; rs41303007; rs41311951; rs28636488; rs11421353; rs41309409; rs41307009; rs3203697; rs41300050; rs41301129; rs41306437; rs41307046; rs1798009; rs41309421; rs35417037; rs34405152; rs41309419; rs11104909; rs41309407; rs9668001; rs35072453; rs41300046; rs41300072; rs11104956; rs34282726; rs41306433; rs11412362; rs34477016; rs34129760; rs41306942; rs7487652; rs41300054; rs10532642; rs5799867; rs41303027; rs41311963; rs41311953; rs11834623; rs35120493; rs3782177; rs41307017; rs41306441; rs41301123; rs41307015; rs41300074; rs35662121; rs41307132; rs41303035; rs35568361; rs41303013; rs41309427; rs35816194; rs41306948; rs41307048; rs1388791; rs12315727; rs28568605; rs1466689; rs41303005; rs41311959; rs1703076; rs34790242; rs5799870; rs41306954; rs41307136; rs34667112; rs7969852; rs41303017; rs12296186; rs7307272; rs41309417; rs41306958; rs41307007; rs2407202; rs41303023; rs5799868; rs34164515; rs41311947; rs41303031; rs34354113; rs4631961; rs11104916; rs41283110; rs41311949; rs3057318; rs41309415; rs41309429; rs41300068; rs1798012; rs4262787; rs41303033; rs12297340; rs12831698; rs35969743; rs34771709; rs34346025; rs41301133; rs34585685; rs11104951; rs41306960; rs11104954; rs41307011; rs41307130; rs1352946; rs34762487; rs5799866; rs34851499; rs41307013; rs41306443; rs41307134; rs1876594; rs41303029; rs34368593; rs41303021; rs41311967; rs11104955; rs3060347; rs41307044; rs34290188; rs41309423; rs41306944; rs1466690; rs34329515; rs2662059; rs41303015; rs41306950; rs41303037; rs41309425; rs12578189; rs35861044; rs36080273; rs11104926; rs41311961; rs41300060; rs41303025; rs1798014; rs35279092; rs34447352; rs1624912; rs35836899; rs41306952; rs3990709; rs2131209; rs5799869; rs41306747; rs41301125; rs34419113; rs34547388; rs11104927; rs41306946; rs12313877; rs11104917; rs36233560; rs11104912; rs11104943; rs41306745; rs10688221; rs7312704; rs1703074; rs7309100; rs41300062; rs11104950; rs41307138; rs41300070; rs35239174; rs10607219; rs1703084; rs2897635; rs35341234; rs41309413; rs2407268; rs41301135; rs2131208; rs11428619; rs34401139; rs1162373; rs11835610; rs12825950; rs35818022; rs34509476; rs41301121; rs41300066; rs41300058; rs41307128; rs35342035; rs41307005; rs41303019; rs41307019; rs41311965; rs12832558; rs41311957; rs11836522; rs41301131; rs5799871; rs41301127; rs1798006; rs41306431; rs34458301; rs11833349; rs35888006; rs35618688; rs1703075; rs41309411; rs3057319; rs35291968; rs12829517; rs12367215; rs35138909; rs1703073; rs34051992; rs41306940; rs12372092; rs34860103; rs11104957; rs1616570; rs34979953; rs11104903; rs1162371; rs12368722; rs12721560; rs12721561; rs1703085

# Macromolecular_Interacting_Partner_18_General_References:
2208279; 10049787; 1379846

# Macromolecular_Interacting_Partner_18_References:
17115933

# Macromolecular_Interacting_Partner_19_ID:
8081

# Macromolecular_Interacting_Partner_19_Name:
Leptin precursor

# Macromolecular_Interacting_Partner_19_Synonyms:
Obesity factor; Obese protein

# Macromolecular_Interacting_Partner_19_Gene_Name:
LEP

# Macromolecular_Interacting_Partner_19_Protein_Sequence:
>Leptin precursor
MHWGTLCGFLWLWPYLFYVQAVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGL
DFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLP
WASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC

# Macromolecular_Interacting_Partner_19_Number_of_Residues:
167

# Macromolecular_Interacting_Partner_19_Molecular_Weight:
18641

# Macromolecular_Interacting_Partner_19_Theoretical_pI:
6.34

# Macromolecular_Interacting_Partner_19_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_19_General_Function:
Not Available

# Macromolecular_Interacting_Partner_19_Specific_Function:
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass

# Macromolecular_Interacting_Partner_19_Pathway:
Not Available

# Macromolecular_Interacting_Partner_19_Reaction:
Not Available

# Macromolecular_Interacting_Partner_19_Pfam_Domain_Function:
PF02024:Leptin

# Macromolecular_Interacting_Partner_19_Signals:
1-21

# Macromolecular_Interacting_Partner_19_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_19_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_19_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_19_GenBank_ID_Protein:
623332

# Macromolecular_Interacting_Partner_19_SwissProt_ID:
LEP_HUMAN (P41159)

# Macromolecular_Interacting_Partner_19_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_19_Genecard_id:
LEP

# Macromolecular_Interacting_Partner_19_Geneatlas_id:
LEP

# Macromolecular_Interacting_Partner_19_hgnc_id:
HGNC:6553

# Macromolecular_Interacting_Partner_19_PDB_ID:
1AX8

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_19_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_19_Gene_Sequence:
>504 bp
ATGCATTGGGGAACCCTGTGCGGATTCTTGTGGCTTTGGCCCTATCTTTTCTATGTCCAA
GCTGTGCCCATCCAAAAAGTCCAAGATGACACCAAAACCCTCATCAAGACAATTGTCACC
AGGATCAATGACATTTCACACACGCAGTCAGTCTCCTCCAAACAGAAAGTCACCGGTTTG
GACTTCATTCCTGGGCTCCACCCCATCCTGACCTTATCCAAGATGGACCAGACACTGGCA
GTCTACCAACAGATCCTCACCAGTATGCCTTCCAGAAACGTGATCCAAATATCCAACGAC
CTGGAGAACCTCCGGGATCTTCTTCACGTGCTGGCCTTCTCTAAGAGCTGCCACTTGCCC
TGGGCCAGTGGCCTGGAGACCTTGGACAGCCTGGGGGGTGTCCTGGAAGCTTCAGGCTAC
TCCACAGAGGTGGTGGCCCTGAGCAGGCTGCAGGGGTCTCTGCAGGACATGCTGTGGCAG
CTGGACCTCAGCCCTGGGTGCTGA

# Macromolecular_Interacting_Partner_19_GenBank_ID_Gene:
U18915

# Macromolecular_Interacting_Partner_19_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_19_Locus:
7q31.3

# Macromolecular_Interacting_Partner_19_SNPs:
rs17151919; rs13306517; rs28954113; rs11763517; rs4731426; rs10954173; rs11761556; rs4731427; rs2167270; rs7791621; rs10257175; rs12706832; rs11760956; rs7795794; rs28954116; rs11978419; rs10244329; rs17151922; rs2278814; rs28959471; rs10954174; rs4236625; rs7796202; rs28954117; rs28959470; rs28954095; rs28954101; rs28954086; rs28954099; rs28959468; rs3750034; rs28954093; rs2278815; rs2122627; rs28954379; rs28959474; rs28954082; rs41457646; rs28954114; rs28954096; rs28959476; rs28954084; rs28954102; rs28954100; rs2060713; rs28954090; rs28954098; rs28954105; rs28954118; rs11980266; rs28954091; rs12706831; rs28959475; rs28954094; rs28954083; rs28756049; rs11973652; rs3793162; rs17151913; rs17151914; rs6956510; rs2071045; rs3828942; rs7788818; rs10264361; rs28954109; rs28954110; rs28954108; rs28954111; rs791616; rs28954376; rs28954081; rs6976701; rs10262600; rs28954369; rs28954080; rs28954371; rs34104384; rs4728096; rs791620; rs28954372; rs28954373; rs28954375; rs35048003; rs28959478; rs10258300; rs12536535; rs28954378; rs13228377; rs1800564; rs1800583; rs28954097; rs11380467; rs35394014; rs28959469; rs10676401; rs28954106; rs1031340; rs28954115; rs1349398; rs34219283; rs28959472; rs28954088; rs10243710; rs6966536; rs28954104; rs10620014; rs34457895; rs13306516; rs33910507; rs28954107; rs41526944; rs41434248; rs28954087; rs34728887; rs28954103; rs28959473; rs41528456; rs17617757; rs28954089; rs28954092; rs34052732; rs10277407; rs28954112; rs41474844; rs13306518; rs35447711; rs34046133; rs36212573; rs28959477; rs36219262; rs791618; rs28954370; rs791619; rs34669250; rs10598051; rs28954377; rs36219261; rs28391558; rs791617; rs28954374; rs36219260; rs10249476; rs10264838; rs10276311; rs10487506; rs10954175; rs10954176; rs11770725; rs12535708; rs12535747; rs12537573; rs13245201; rs1349419; rs1376268; rs16871960; rs17151895; rs2060715; rs2167271; rs35854831; rs4731423; rs4731424; rs4731428; rs4731429; rs4731430; rs6949498; rs712722; rs7778154; rs7782257; rs7798338; rs7799039; rs7801674; rs7802530; rs791604; rs791606; rs791607; rs791608; rs791610; rs791611; rs791612; rs791613; rs791614; rs791615

# Macromolecular_Interacting_Partner_19_General_References:
7984236; 7789654; 8626726; 7499240; 8621021; 10428856; 9166907; 9144295; 9500540

# Macromolecular_Interacting_Partner_19_References:
17093945; 17121306; 17130635

# Macromolecular_Interacting_Partner_20_ID:
8452

# Macromolecular_Interacting_Partner_20_Name:
Lymphotoxin-beta

# Macromolecular_Interacting_Partner_20_Synonyms:
LT-beta; Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3

# Macromolecular_Interacting_Partner_20_Gene_Name:
LTB

# Macromolecular_Interacting_Partner_20_Protein_Sequence:
>Lymphotoxinbeta
MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD
PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS
DAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLE
GAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGA
VMVG

# Macromolecular_Interacting_Partner_20_Number_of_Residues:
244

# Macromolecular_Interacting_Partner_20_Molecular_Weight:
25390

# Macromolecular_Interacting_Partner_20_Theoretical_pI:
5.02

# Macromolecular_Interacting_Partner_20_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_20_General_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Specific_Function:
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional

# Macromolecular_Interacting_Partner_20_Pathway:
Not Available

# Macromolecular_Interacting_Partner_20_Reaction:
Not Available

# Macromolecular_Interacting_Partner_20_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_20_Signals:
1-35

# Macromolecular_Interacting_Partner_20_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_20_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_20_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_20_GenBank_ID_Protein:
292279

# Macromolecular_Interacting_Partner_20_SwissProt_ID:
TNFC_HUMAN (Q06643)

# Macromolecular_Interacting_Partner_20_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_20_Genecard_id:
LTB

# Macromolecular_Interacting_Partner_20_Geneatlas_id:
LTB

# Macromolecular_Interacting_Partner_20_hgnc_id:
HGNC:6711

# Macromolecular_Interacting_Partner_20_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_20_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_20_Gene_Sequence:
>735 bp
ATGGGGGCACTGGGGCTGGAGGGCAGGGGTGGGAGGCTCCAGGGGAGGGGTTCCCTCCTG
CTAGCTGTGGCAGGAGCCACTTCTCTGGTGACCTTGTTGCTGGCGGTGCCTATCACTGTC
CTGGCTGTGCTGGCCTTAGTGCCCCAGGATCAGGGAGGACTGGTAACGGAGACGGCCGAC
CCCGGGGCACAGGCCCAGCAAGGACTGGGGTTTCAGAAGCTGCCAGAGGAGGAGCCAGAA
ACAGATCTCAGCCCCGGGCTCCCAGCTGCCCACCTCATAGGCGCTCCGCTGAAGGGGCAG
GGGCTAGGCTGGGAGACGACGAAGGAACAGGCGTTTCTGACGAGCGGGACGCAGTTCTCG
GACGCCGAGGGGCTGGCGCTCCCGCAGGACGGCCTCTATTACCTCTACTGTCTCGTCGGC
TACCGGGGCCGGGCGCCCCCTGGCGGCGGGGACCCCCAGGGCCGCTCGGTCACGCTGCGC
AGCTCTCTGTACCGGGCGGGGGGCGCCTACGGGCCGGGCACTCCCGAGCTGCTGCTCGAG
GGCGCCGAGACGGTGACTCCAGTGCTGGACCCGGCCAGGAGACAAGGGTACGGGCCTCTC
TGGTACACGAGCGTGGGGTTCGGCGGCCTGGTGCAGCTCCGGAGGGGCGAGAGGGTGTAC
GTCAACATCAGTCACCCCGATATGGTGGACTTCGCGAGAGGGAAGACCTTCTTTGGGGCC
GTGATGGTGGGGTGA

# Macromolecular_Interacting_Partner_20_GenBank_ID_Gene:
L11016

# Macromolecular_Interacting_Partner_20_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_20_Locus:
6p21.3

# Macromolecular_Interacting_Partner_20_SNPs:
Not Available

# Macromolecular_Interacting_Partner_20_General_References:
7916655; 9299492; 10202016

# Macromolecular_Interacting_Partner_20_References:
17056184

# Macromolecular_Interacting_Partner_21_ID:
8417

# Macromolecular_Interacting_Partner_21_Name:
Glucokinase regulatory protein

# Macromolecular_Interacting_Partner_21_Synonyms:
Glucokinase regulator

# Macromolecular_Interacting_Partner_21_Gene_Name:
GCKR

# Macromolecular_Interacting_Partner_21_Protein_Sequence:
>Glucokinase regulatory protein
MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEI
FQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVS
FNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISV
GLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQ
KAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFE
RAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDV
RGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIFTLDDNLTEVQ
TIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISITWPLLFFEYEGNFIQKFQREL
STKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRALAMLQRFSGQSKARCIESLLR
AIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEA
VRSALAGPGQKRTADPLEILEPDVQ

# Macromolecular_Interacting_Partner_21_Number_of_Residues:
625

# Macromolecular_Interacting_Partner_21_Molecular_Weight:
68686

# Macromolecular_Interacting_Partner_21_Theoretical_pI:
6.68

# Macromolecular_Interacting_Partner_21_GO_Classification:
>>>
Function:  enzyme regulator activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_21_General_Function:
Not Available

# Macromolecular_Interacting_Partner_21_Specific_Function:
Inhibits glucokinase by forming an inactive complex with this enzyme

# Macromolecular_Interacting_Partner_21_Pathway:
Not Available

# Macromolecular_Interacting_Partner_21_Reaction:
Not Available

# Macromolecular_Interacting_Partner_21_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_21_Signals:
None

# Macromolecular_Interacting_Partner_21_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_21_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_21_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_21_GenBank_ID_Protein:
683572

# Macromolecular_Interacting_Partner_21_SwissProt_ID:
GCKR_HUMAN (Q14397)

# Macromolecular_Interacting_Partner_21_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_21_Genecard_id:
GCKR

# Macromolecular_Interacting_Partner_21_Geneatlas_id:
GCKR

# Macromolecular_Interacting_Partner_21_hgnc_id:
HGNC:4196

# Macromolecular_Interacting_Partner_21_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_21_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_21_Gene_Sequence:
>1878 bp
ATGCCAGGCACAAAACGGTTTCAACATGTCATTGAGACCCCGGAGCCTGGCAAGTGGGAG
TTGTCTGGGTACGAGGCAGCTGTGCCAATCACGGAGAAGTCAAACCCACTGACCCAGGAT
CTAGACAAAGCAGATGCTGAGAACATTGTTCGACTGCTAGGGCAATGTGATGCTGAGATC
TTCCAGGAGGAGGGGCAAGCCCTGTCCACATACCAGAGACTCTACAGCGAATCCATTCTG
ACCACCATGGTACAGGTGGCTGGGAAAGTTCAGGAAGTGCTGAAGGAGCCAGATGGGGGG
CTGGTTGTGCTGAGTGGAGGGGGCACCTCTGGCCGGATGGCATTCCTCATGTCGGTGTCC
TTTAATCAGCTGATGAAAGGTCTGGGACAGAAACCTCTTTACACCTACCTCATTGCAGGT
GGTGACAGGTCTGTGGTGGCCTCTAGGGAGGGGACAGAAGATAGTGCCTTGCACGGGATT
GAGGAACTGAAGAAGGTGGCTGCCGGGAAGAAGAGAGTGATTGTCATTGGCATTTCTGTG
GGACTCTCTGCTCCCTTTGTGGCAGGCCAGATGGACTGCTGCATGAACAACACAGCTGTC
TTCTTGCCAGTCCTGGTTGGCTTCAATCCAGTGAGCATGGCCAGAAATGACCCCATTGAA
GACTGGAGTTCAACATTCCGACAAGTAGCAGAGCGGATGCAGAAAATGCAGGAGAAACAG
AAAGCTTTTGTGCTCAATCCTGCCATCGGGCCCGAGGGTCTCAGCGGCTCCTCCCGGATG
AAAGGTGGAAGTGCCACCAAGATTCTGCTGGAAACCCTGTTATTAGCAGCCCATAAGACT
GTGGACCAGGGCATTGCAGCATCTCAAAGATGCCTCCTGGAAATCTTGCGGACATTTGAG
CGAGCTCATCAGGTGACCTACAGCCAAAGCCCCAAGATTGCCACCCTGATGAAGAGTGTC
AGCACCAGTCTGGAGAAGAAAGGCCACGTGTACCTGGTTGGCTGGCAGACCCTGGGTATC
ATTGCCATCATGGATGGAGTAGAGTGCATCCACACCTTTGGTGCTGATTTCCGAGATGTC
CGTGGCTTTCTCATTGGTGATCACAGTGACATGTTTAACCAGAAGGCTGAGCTCACCAAC
CAGGGTCCCCAGTTCACCTTCTCCCAGGAGGACTTCCCGACTTCCATCCTTCCCTCTCTC
ACGGAAATCGATACTGTGGTCTTCATTTTCACCCTGGATGACAACCTCACGGAGGTGCAG
ACTATAGTGGAGCAGGTGAAAGAGAAGACCAACCACATCCAGGCCCTGGCACACAGCACC
GTGGGTCAGACCTTGCCGATCCCTCTGAAGAAGCTCTTTCCCTCCATCATCAGCATCACA
TGGCCACTGCTTTTCTTTGAATATGAAGGGAACTTCATCCAGAAGTTCCAGCGTGAGCTA
AGCACCAAATGGGTGCTGAATACAGTGAGTACAGGTGCTCATGTGCTTCTTGGTAAGATC
CTACAAAACCACATGTTGGACCTTCGGATTAGCAACTCCAAGCTCTTCTGGCGGGCGCTG
GCCATGCTGCAGCGGTTCTCTGGACAGTCCAAGGCTCGATGCATCGAGAGCCTCCTCCGA
GCGATCCACTTTCCCCAGCCACTGTCAGATGATATTCGGGCTGCTCCCATCTCCTGCCGT
GTCCAGGTTGCACATGAGAAGGAACAGGTGATACCCATCGCCTTGCTGAGCCTCCTATTC
CGGTGCTCGATCACTGAGGCTCAGGCACACCTGGCTGCAGCTCCTTCTGTCTGTGAGGCT
GTCAGGAGTGCTCTTGCTGGGCCAGGTCAGAAGCGCACTGCGGACCCCCTCGAGATCCTA
GAGCCTGACGTTCAGTGA

# Macromolecular_Interacting_Partner_21_GenBank_ID_Gene:
Z48475

# Macromolecular_Interacting_Partner_21_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_21_Locus:
2p23

# Macromolecular_Interacting_Partner_21_SNPs:
rs1260326; rs8179249; rs704790; rs814295; rs780094; rs715325; rs780093; rs780092; rs715326; rs1260320; rs813592; rs6735762; rs11127044; rs780095; rs7589217; rs10169261; rs8179235; rs8179213; rs8179225; rs2293571; rs11681351; rs8179219; rs8179236; rs780096; rs3817588; rs2293572; rs8179242; rs8179228; rs8179248; rs6547692; rs13394224; rs12466018; rs12471703; rs12472643; rs2032971; rs889990; rs4425043; rs8179252; rs8179251; rs34498189; rs34792470; rs8179212; rs34316866; rs8179207; rs34326658; rs41291159; rs8179239; rs8179216; rs812955; rs8179232; rs13022659; rs8179211; rs8179231; rs8179221; rs10686678; rs8179241; rs13024376; rs8179234; rs35008972; rs8179215; rs34318823; rs41291157; rs8179223; rs35843492; rs35073769; rs11393265; rs8179246; rs8179237; rs34070225; rs41291155; rs8179245; rs8179226; rs34625318; rs9711035; rs11679089; rs6744137; rs34507360; rs8179209; rs35189790; rs11295580; rs11285570; rs7422925; rs8179220; rs8179217; rs8179233; rs35372959; rs35204632; rs35348937; rs2384625; rs8179230; rs8179210; rs8179222; rs11325709; rs35738265; rs8179243; rs1270255; rs8179240; rs8179229; rs8179250; rs8179214; rs10600159; rs34648846; rs8179218; rs12475764; rs8179247; rs10549495; rs8179244; rs8179224; rs8179208; rs8179227; rs11904646; rs1260328; rs1260333; rs1647285; rs2272415; rs2288155; rs2293573; rs2303369; rs3180420; rs4270306; rs4665987; rs6707529; rs704795; rs7583698; rs780090; rs8179205; rs8179253; rs8395; rs9188; rs9974

# Macromolecular_Interacting_Partner_21_General_References:
8589523; 9570959

# Macromolecular_Interacting_Partner_21_References:
17028192; 17082186

# Macromolecular_Interacting_Partner_22_ID:
8008

# Macromolecular_Interacting_Partner_22_Name:
Adiponectin precursor

# Macromolecular_Interacting_Partner_22_Synonyms:
Adipocyte, C1q and collagen domain-containing protein; 30 kDa adipocyte complement-related protein; Adipocyte complement-related 30 kDa protein; ACRP30; Adipose most abundant gene transcript 1; apM-1; Gelatin-binding protein

# Macromolecular_Interacting_Partner_22_Gene_Name:
ADIPOQ

# Macromolecular_Interacting_Partner_22_Protein_Sequence:
>Adiponectin precursor
MLLLGAVLLLLALPGHDQETTTQGPGVLLPLPKGACTGWMAGIPGHPGHNGAPGRDGRDG
TPGEKGEKGDPGLIGPKGDIGETGVPGAEGPRGFPGIQGRKGEPGEGAYVYRSAFSVGLE
TYVTIPNMPIRFTKIFYNQQNHYDGSTGKFHCNIPGLYYFAYHITVYMKDVKVSLFKKDK
AMLFTYDQYQENNVDQASGSVLLHLEVGDQVWLQVYGEGERNGLYADNDNDSTFTGFLLY
HDTN

# Macromolecular_Interacting_Partner_22_Number_of_Residues:
244

# Macromolecular_Interacting_Partner_22_Molecular_Weight:
26414

# Macromolecular_Interacting_Partner_22_Theoretical_pI:
5.53

# Macromolecular_Interacting_Partner_22_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_22_General_Function:
Not Available

# Macromolecular_Interacting_Partner_22_Specific_Function:
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW

# Macromolecular_Interacting_Partner_22_Pathway:
Not Available

# Macromolecular_Interacting_Partner_22_Reaction:
Not Available

# Macromolecular_Interacting_Partner_22_Pfam_Domain_Function:
PF00386:C1q;
PF01391:Collagen

# Macromolecular_Interacting_Partner_22_Signals:
1-18

# Macromolecular_Interacting_Partner_22_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_22_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_22_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_22_GenBank_ID_Protein:
871887

# Macromolecular_Interacting_Partner_22_SwissProt_ID:
ADIPO_HUMAN (Q15848)

# Macromolecular_Interacting_Partner_22_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_22_Genecard_id:
ADIPOQ

# Macromolecular_Interacting_Partner_22_Geneatlas_id:
ADIPOQ

# Macromolecular_Interacting_Partner_22_hgnc_id:
HGNC:13633

# Macromolecular_Interacting_Partner_22_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_22_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_22_Gene_Sequence:
>735 bp
ATGCTGTTGCTGGGAGCTGTTCTACTGCTATTAGCTCTGCCCGGGCATGACCAGGAAACC
ACGACTCAAGGGCCCGGAGTCCTGCTTCCCCTGCCCAAGGGGGCCTGCACAGGTTGGATG
GCGGGCATCCCAGGGCATCCGGGCCATAATGGGGCCCCAGGCCGTGATGGCAGAGATGGC
ACCCCTGGTGAGAAGGGTGAGAAAGGAGATCCAGGTCTTATTGGTCCTAAGGGAGACATC
GGTGAAACCGGAGTACCCGGGGCTGAAGGTCCCCGAGGCTTTCCGGGAATCCAAGGCAGG
AAAGGAGAACCTGGAGAAGGTGCCTATGTATACCGCTCAGCATTCAGTGTGGGATTGGAG
ACTTACGTTACTATCCCCAACATGCCCATTCGCTTTACCAAGATCTTCTACAATCAGCAA
AACCACTATGATGGCTCCACTGGTAAATTCCACTGCAACATTCCTGGGCTGTACTACTTT
GCCTACCACATCACAGTCTATATGAAGGATGTGAAGGTCAGCCTCTTCAAGAAGGACAAG
GCTATGCTCTTCACCTATGATCAGTACCAGGAAAATAATGTGGACCAGGCCTCCGGCTCT
GTGCTCCTGCATCTGGAGGTGGGCGACCAAGTCTGGCTCCAGGTGTATGGGGAAGGAGAG
CGTAATGGACTCTATGCTGATAATGACAATGACTCCACCTTCACAGGCTTTCTTCTCTAC
CATGACACCAACTGA

# Macromolecular_Interacting_Partner_22_GenBank_ID_Gene:
D45371

# Macromolecular_Interacting_Partner_22_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_22_Locus:
3q27

# Macromolecular_Interacting_Partner_22_SNPs:
rs17366743; rs2241766; rs2082940; rs1063537; rs1063539; rs822394; rs7649121; rs1063538; rs182052; rs9877202; rs7627128; rs822395; rs12495941; rs6773957; rs6444174; rs4686804; rs17366568; rs6414520; rs9882205; rs822396; rs4686803; rs822388; rs16861205; rs822389; rs16861209; rs11711059; rs6444172; rs822393; rs9842733; rs1501298; rs16861210; rs2036373; rs17366653; rs4068; rs12635510; rs17846866; rs822391; rs9882097; rs3774262; rs2241767; rs3821799; rs3774261; rs1501299; rs266729; rs17300539; rs1403697; rs16861194; rs12492612; rs13061862; rs12639220; rs10575960; rs35469083; rs710445; rs34046054; rs35759948; rs12494576; rs17846865; rs34534547; rs34422369; rs16861222; rs34463314; rs36219755; rs1501297; rs11451767; rs11434648; rs36219760; rs11412081; rs17366499; rs34225626; rs13066093; rs35993781; rs11429836; rs35378606; rs16861220; rs17846872; rs36219758; rs35615373; rs822392; rs35310830; rs10662925; rs10662615; rs10545762; rs36219762; rs34265972; rs33955672; rs35595243; rs6789230; rs7649044; rs6796106; rs11377702; rs12495855; rs34513325; rs4686440; rs34568537; rs34156726; rs35088921; rs34814577; rs266730; rs11711353; rs12629945; rs1403695; rs1403696; rs1648707; rs17373414; rs1827311; rs1865762; rs34187390; rs4607097; rs4632532; rs6444175; rs6808791; rs7628649; rs7641507; rs7653711; rs864265

# Macromolecular_Interacting_Partner_22_General_References:
8619847; 10095105; 10403784; 10961870; 10982546; 11479627; 10918532; 11812766

# Macromolecular_Interacting_Partner_22_References:
17074368; 17112529

# Macromolecular_Interacting_Partner_23_ID:
8373

# Macromolecular_Interacting_Partner_23_Name:
Hypoxia-inducible factor 1 alpha

# Macromolecular_Interacting_Partner_23_Synonyms:
HIF-1 alpha; HIF1 alpha; ARNT- interacting protein; Member of PAS protein 1; Basic-helix-loop- helix-PAS protein MOP1

# Macromolecular_Interacting_Partner_23_Gene_Name:
HIF1A

# Macromolecular_Interacting_Partner_23_Protein_Sequence:
>Hypoxiainducible factor 1 alpha
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP
NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT
VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR
DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR
KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC
RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN

# Macromolecular_Interacting_Partner_23_Number_of_Residues:
826

# Macromolecular_Interacting_Partner_23_Molecular_Weight:
92671

# Macromolecular_Interacting_Partner_23_Theoretical_pI:
4.97

# Macromolecular_Interacting_Partner_23_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein histidine kinase activity
Function:  two-component sensor molecule activity
Function:  signal transducer activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
Function:  transcription regulator activity
 ||
>>>
Process:  two-component signal transduction system (phosphorelay)
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  regulation of transcription, DNA-dependent
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_23_General_Function:
Signal transduction mechanisms 

# Macromolecular_Interacting_Partner_23_Specific_Function:
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP

# Macromolecular_Interacting_Partner_23_Pathway:
Not Available

# Macromolecular_Interacting_Partner_23_Reaction:
Not Available

# Macromolecular_Interacting_Partner_23_Pfam_Domain_Function:
PF08778:HIF-1a_CTAD;
PF00010:HLH;
PF08447:PAS_3

# Macromolecular_Interacting_Partner_23_Signals:
None

# Macromolecular_Interacting_Partner_23_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_23_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_23_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_23_GenBank_ID_Protein:
881346

# Macromolecular_Interacting_Partner_23_SwissProt_ID:
HIF1A_HUMAN (Q16665)

# Macromolecular_Interacting_Partner_23_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_23_Genecard_id:
HIF1A

# Macromolecular_Interacting_Partner_23_Geneatlas_id:
HIF1A

# Macromolecular_Interacting_Partner_23_hgnc_id:
HGNC:4910

# Macromolecular_Interacting_Partner_23_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_23_Subcellular_Location:
Cytoplasm. Nucleus. Note=Cytoplasmic in normoxia, nuclear translocation in response to hypoxia

# Macromolecular_Interacting_Partner_23_Gene_Sequence:
>2481 bp
ATGGAGGGCGCCGGCGGCGCGAACGACAAGAAAAAGATAAGTTCTGAACGTCGAAAAGAA
AAGTCTCGAGATGCAGCCAGATCTCGGCGAAGTAAAGAATCTGAAGTTTTTTATGAGCTT
GCTCATCAGTTGCCACTTCCACATAATGTGAGTTCGCATCTTGATAAGGCCTCTGTGATG
AGGCTTACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATT
GAAGATGACATGAAAGCACAGATGAATTGCTTTTATTTGAAAGCCTTGGATGGTTTTGTT
ATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATACATG
GGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGAC
CATGAGGAAATGAGAGAAATGCTTACACACAGAAATGGCCTTGTGAAAAAGGGTAAAGAA
CAAAACACACAGCGAAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGAGGAAGA
ACTATGAACATAAAGTCTGCAACATGGAAGGTATTGCACTGCACAGGCCACATTCACGTA
TATGATACCAACAGTAACCAACCTCAGTGTGGGTATAAGAAACCACCTATGACCTGCTTG
GTGCTGATTTGTGAACCCATTCCTCACCCATCAAATATTGAAATTCCTTTAGATAGCAAG
ACTTTCCTCAGTCGACACAGCCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACC
GAATTGATGGGATATGAGCCAGAAGAACTTTTAGGCCGCTCAATTTATGAATATTATCAT
GCTTTGGACTCTGATCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAAGTC
ACCACAGGACAGTACAGGATGCTTGCCAAAAGAGGTGGATATGTCTGGGTTGAAACTCAA
GCAACTGTCATATATAACACCAAGAATTCTCAACCACAGTGCATTGTATGTGTGAATTAC
GTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGTGTC
CTTAAACCGGTTGAATCTTCAGATATGAAAATGACTCAGCTATTCACCAAAGTTGAATCA
GAAGATACAAGTAGCCTCTTTGACAAACTTAAGAAGGAACCTGATGCTTTAACTTTGCTG
GCCCCAGCCGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAACGACACAGAAACT
GATGACCAGCAACTTGAGGAAGTACCATTATATAATGATGTAATGCTCCCCTCACCCAAC
GAAAAATTACAGAATATAAATTTGGCAATGTCTCCATTACCCACCGCTGAAACGCCAAAG
CCACTTCGAAGTAGTGCTGACCCTGCACTCAATCAAGAAGTTGCATTAAAATTAGAACCA
AATCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAGGATCAGACACCTAGT
CCTTCCGATGGAAGCACTAGACAAAGTTCACCTGAGCCTAATAGTCCCAGTGAATATTGT
TTTTATGTGGATAGTGATATGGTCAATGAATTCAAGTTGGAATTGGTAGAAAAACTTTTT
GCTGAAGACACAGAAGCAAAGAACCCATTTTCTACTCAGGACACAGATTTAGACTTGGAG
ATGTTAGCTCCCTATATCCCAATGGATGATGACTTCCAGTTACGTTCCTTCGATCAGTTG
TCACCATTAGAAAGCAGTTCCGCAAGCCCTGAAAGCGCAAGTCCTCAAAGCACAGTTACA
GTATTCCAGCAGACTCAAATACAAGAACCTACTGCTAATGCCACCACTACCACTGCCACC
ACTGATGAATTAAAAACAGTGACAAAAGACCGTATGGAAGACATTAAAATATTGATTGCA
TCTCCATCTCCTACCCACATACATAAAGAAACTACTAGTGCCACATCATCACCATATAGA
GATACTCAAAGTCGGACAGCCTCACCAAACAGAGCAGGAAAAGGAGTCATAGAACAGACA
GAAAAATCTCATCCAAGAAGCCCTAACGTGTTATCTGTCGCTTTGAGTCAAAGAACTACA
GTTCCTGAGGAAGAACTAAATCCAAAGATACTAGCTTTGCAGAATGCTCAGAGAAAGCGA
AAAATGGAACATGATGGTTCACTTTTTCAAGCAGTAGGAATTGGAACATTATTACAGCAG
CCAGACGATCATGCAGCTACTACATCACTTTCTTGGAAACGTGTAAAAGGATGCAAATCT
AGTGAACAGAATGGAATGGAGCAAAAGACAATTATTTTAATACCCTCTGATTTAGCATGT
AGACTGCTGGGGCAATCAATGGATGAAAGTGGATTACCACAGCTGACCAGTTATGATTGT
GAAGTTAATGCTCCTATACAAGGCAGCAGAAACCTACTGCAGGGTGAAGAATTACTCAGA
GCTTTGGATCAAGTTAACTGA

# Macromolecular_Interacting_Partner_23_GenBank_ID_Gene:
U22431

# Macromolecular_Interacting_Partner_23_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_23_Locus:
14q21-q24

# Macromolecular_Interacting_Partner_23_SNPs:
rs11549467; rs11549465; rs17099141; rs2057482; rs41398644; rs2301111; rs12435848; rs2301108; rs10873142; rs10135579; rs3783752; rs10147275; rs4902080; rs966824; rs11158358; rs8020184; rs8005745; rs1957757; rs7156573; rs10148514; rs12434438; rs10144011; rs4899056; rs2301106; rs2301113; rs1957756; rs1951795; rs10138153; rs1555585; rs10129270; rs2284999; rs11158357; rs10137588; rs10138032; rs7143164; rs4902082; rs1957754; rs1015447; rs10139578; rs7158683; rs3783751; rs1555584; rs2301112; rs12232182; rs8012370; rs4902081; rs10459450; rs6573397; rs17099143; rs4899057; rs2181600; rs10137529; rs962962; rs2301115; rs12896279; rs1957755; rs11851112; rs11621525; rs1967773; rs2301110; rs7161527; rs2301109; rs2301104; rs12885226; rs17256373; rs10146037; rs994740; rs41508050; rs1802821; rs11549468; rs41492849; rs34005929; rs34873475; rs33930665; rs11549466; rs17099190; rs5809121; rs8019084; rs41285516; rs35244739; rs34312928; rs12887165; rs11279176; rs35092820; rs10615565; rs11470130; rs10658676; rs17099146; rs17099114; rs17099117; rs35667836; rs12881961; rs12050207; rs34524939; rs10538225; rs34679569; rs35651869; rs10615564; rs7152775; rs5809118; rs36189686; rs28464725; rs34138408; rs7159740; rs3062103; rs17834635; rs35675133; rs34251430; rs12892205; rs3831892; rs35638635; rs34718743; rs5809116; rs34742261; rs35312129; rs11622129; rs10148312; rs2301105; rs35018703; rs5809120; rs5809119; rs35757892; rs41467354; rs11335043; rs3062105; rs17099144; rs35341362; rs7158929; rs10645014; rs3837622; rs34106499; rs41483044; rs34533346; rs41285514; rs2057481; rs35252062; rs3216697; rs35041916; rs6573398; rs7159736; rs12100452; rs12882000; rs3059957; rs34767998; rs17834617; rs17099140; rs36125594; rs7159535; rs12891737; rs2352598; rs34356353; rs1040995; rs2301107; rs35473541; rs34726371; rs35754318; rs17099135; rs34675544; rs5809117; rs5809115; rs984788; rs34644064; rs7156167; rs4902079; rs35441000; rs41362550; rs34794011; rs10131386; rs10133889; rs10140886; rs10141036; rs10151556; rs11625031; rs11627835; rs11847020; rs12385907; rs12888392; rs12888409; rs1319462; rs1535679; rs2146871; rs4902083; rs7143626; rs9989175

# Macromolecular_Interacting_Partner_23_General_References:
7539918; 9079689; 9782081; 9235919; 9822602; 9653127; 10202154; 10594042; 10758161; 11292861; 11598268; 12464182; 12080085; 12560087; 10950862; 11089639; 12446723; 11959990; 11959977; 12004076; 12050673

# Macromolecular_Interacting_Partner_23_References:
17043658

# Macromolecular_Interacting_Partner_24_ID:
8160

# Macromolecular_Interacting_Partner_24_Name:
Resistin precursor

# Macromolecular_Interacting_Partner_24_Synonyms:
Cysteine-rich secreted protein FIZZ3; Adipose tissue-specific secretory factor; ADSF; C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; Cysteine-rich secreted protein A12-alpha-like 2

# Macromolecular_Interacting_Partner_24_Gene_Name:
RETN

# Macromolecular_Interacting_Partner_24_Protein_Sequence:
>Resistin precursor
MKALCLLLLPVLGLLVSSKTLCSMEEAINERIQEVAGSLIFRAISSIGLECQSVTSRGDL
ATCPRGFAVTGCTCGSACGSWDVRAETTCHCQCAGMDWTGARCCRVQP

# Macromolecular_Interacting_Partner_24_Number_of_Residues:
108

# Macromolecular_Interacting_Partner_24_Molecular_Weight:
11419

# Macromolecular_Interacting_Partner_24_Theoretical_pI:
6.89

# Macromolecular_Interacting_Partner_24_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_24_General_Function:
Not Available

# Macromolecular_Interacting_Partner_24_Specific_Function:
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes

# Macromolecular_Interacting_Partner_24_Pathway:
Not Available

# Macromolecular_Interacting_Partner_24_Reaction:
Not Available

# Macromolecular_Interacting_Partner_24_Pfam_Domain_Function:
PF06954:Resistin

# Macromolecular_Interacting_Partner_24_Signals:
1-18

# Macromolecular_Interacting_Partner_24_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_24_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_24_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_24_GenBank_ID_Protein:
9931333

# Macromolecular_Interacting_Partner_24_SwissProt_ID:
RETN_HUMAN (Q9HD89)

# Macromolecular_Interacting_Partner_24_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_24_Genecard_id:
RETN

# Macromolecular_Interacting_Partner_24_Geneatlas_id:
RETN

# Macromolecular_Interacting_Partner_24_hgnc_id:
HGNC:20389

# Macromolecular_Interacting_Partner_24_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_24_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_24_Gene_Sequence:
>327 bp
ATGAAAGCTCTCTGTCTCCTCCTCCTCCCTGTCCTGGGGCTGTTGGTGTCTAGCAAGACC
CTGTGCTCCATGGAAGAAGCCATCAATGAGAGGATCCAGGAGGTCGCCGGCTCCCTAATA
TTTAGGGCAATAAGCAGCATTGGCCTGGAGTGCCAGAGCGTCACCTCCAGGGGGGACCTG
GCTACTTGCCCCCGAGGCTTCGCCGTCACCGGCTGCACTTGTGGCTCCGCCTGTGGCTCG
TGGGATGTGCGCGCCGAGACCACATGTCACTGCCAGTGCGCGGGCATGGACTGGACCGGA
GCGCGCTGCTGTCGTGTGCAGCCCTGA

# Macromolecular_Interacting_Partner_24_GenBank_ID_Gene:
AF205952

# Macromolecular_Interacting_Partner_24_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_24_Locus:
19p13.2

# Macromolecular_Interacting_Partner_24_SNPs:
rs3745368; rs3219176; rs35547567; rs3745367; rs3219178; rs10402265; rs3219177; rs12981326; rs34788323; rs1862513; rs3745369; rs7408449; rs3219175; rs34861192; rs3760678; rs34124816; rs12459044; rs35657925; rs10402306; rs11667432; rs11668394; rs17847440; rs35139946; rs11270887; rs35507159; rs17847442; rs34981023; rs36204113; rs36203768; rs36204112; rs7408174; rs36204109; rs3833230; rs34727385; rs34431688; rs34394061; rs12985832; rs36019626; rs10387740; rs36204404; rs7249130; rs36204110; rs34051686; rs12985865; rs35069217; rs36203769; rs10401670; rs10402974; rs10411016; rs10418380; rs11880289; rs11880394; rs12460179; rs12610253; rs1423096; rs4804765; rs4804766; rs8103654; rs8109598; rs8111596; rs889183

# Macromolecular_Interacting_Partner_24_General_References:
10921885; 11201732; 11090083; 12975309

# Macromolecular_Interacting_Partner_24_References:
17049721

# Macromolecular_Interacting_Partner_25_ID:
8040

# Macromolecular_Interacting_Partner_25_Name:
Low affinity sodium-glucose cotransporter

# Macromolecular_Interacting_Partner_25_Synonyms:
Sodium/glucose cotransporter 3; Na(+/glucose cotransporter 3

# Macromolecular_Interacting_Partner_25_Gene_Name:
SLC5A4

# Macromolecular_Interacting_Partner_25_Protein_Sequence:
>Low affinity sodiumglucose cotransporter
MASTVSPSTIAETPEPPPLSDHIRNAADISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFL
AGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIY
IKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLA
IFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNAT
PSVVEGDNLTISASCYTPRADSFHIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQR
CLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCGVDVG
CTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEK
ELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRV
NEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLV
TLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIDAEEKSQEETDDGVEEDYPEKSRGCLK
KAYDLFCGLQKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA

# Macromolecular_Interacting_Partner_25_Number_of_Residues:
659

# Macromolecular_Interacting_Partner_25_Molecular_Weight:
72456

# Macromolecular_Interacting_Partner_25_Theoretical_pI:
6.06

# Macromolecular_Interacting_Partner_25_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_25_General_Function:
Not Available

# Macromolecular_Interacting_Partner_25_Specific_Function:
Sodium-dependent glucose transporter

# Macromolecular_Interacting_Partner_25_Pathway:
Not Available

# Macromolecular_Interacting_Partner_25_Reaction:
Not Available

# Macromolecular_Interacting_Partner_25_Pfam_Domain_Function:
PF00474:SSF

# Macromolecular_Interacting_Partner_25_Signals:
None

# Macromolecular_Interacting_Partner_25_Transmembrane_Regions:
29-47
65-85
106-126
172-191
209-229
271-291
315-334
424-443
456-476
527-547
638-658

# Macromolecular_Interacting_Partner_25_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_25_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_25_GenBank_ID_Protein:
7263938

# Macromolecular_Interacting_Partner_25_SwissProt_ID:
SC5A4_HUMAN (Q9NY91)

# Macromolecular_Interacting_Partner_25_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_25_Genecard_id:
SLC5A4

# Macromolecular_Interacting_Partner_25_Geneatlas_id:
SLC5A4

# Macromolecular_Interacting_Partner_25_hgnc_id:
HGNC:11039

# Macromolecular_Interacting_Partner_25_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_25_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_25_Gene_Sequence:
>1980 bp
ATGGCCAGTACGGTTAGCCCCAGCACCATAGCTGAGACCCCAGAGCCACCTCCATTGTCT
GACCACATCCGAAATGCTGCTGACATCTCAGTCATTGTCATCTATTTTCTGGTGGTGATG
GCTGTTGGGCTGTGGGCGATGCTGAAGACCAACCGAGGTACTATAGGAGGCTTCTTCCTC
GCTGGTCGTGATATGGCCTGGTGGCCGATGGGCGCCTCTCTCTTTGCCAGTAACATCGGC
AGCAACCACTATGTGGGGCTGGCTGGGACAGGAGCAGCTTCAGGAGTCGCCACCGTAACA
TTTGAATGGACTTCCTCAGTAATGTTGCTGATTCTTGGGTGGATCTTTGTCCCTATCTAC
ATCAAGTCGGGGGTGATGACCATGCCGGAATATCTCAAGAAGCGGTTTGGTGGGGAGCGA
CTCCAGGTCTACCTCTCCATCCTCTCCCTCTTCATCTGTGTGGTTTTGTTAATTTCTGCA
GACATATTTGCTGGAGCCATATTCATCAAGCTGGCCTTGGGATTGGACCTTTACCTGGCA
ATCTTCATCCTCTTGGCTATGACTGCTGTTTACACCACCACTGGGGGCTTGGCCTCGGTG
ATTTACACAGACACCCTCCAGACCATCATCATGCTGATTGGCTCTTTTATTCTCATGGGG
TTTGCATTTAACGAAGTTGGAGGTTATGAGAGCTTTACCGAGAAGTACGTGAATGCCACC
CCATCCGTAGTCGAGGGGGACAACTTGACAATCAGTGCCAGTTGCTACACACCTCGGGCG
GACTCCTTCCATATCTTCCGAGATGCTGTGACTGGGGACATTCCATGGCCAGGAATTATA
TTTGGAATGCCCATTACAGCTTTGTGGTACTGGTGCACAAATCAGGTCATTGTGCAGCGC
TGCCTGTGTGGCAAGGACATGTCTCACGTGAAGGCCGCTTGCATTATGTGTGCTTACCTG
AAGCTGCTGCCCATGTTCCTCATGGTGATGCCGGGGATGATCAGCCGCATCCTGTACACA
GATATGGTAGCATGTGTGGTACCTTCTGAATGCGTGAAACACTGTGGCGTTGATGTTGGC
TGCACCAACTACGCATACCCCACGATGGTGCTGGAACTGATGCCCCAAGGACTGCGAGGC
CTGATGCTTTCGGTCATGCTGGCCTCTCTCATGAGCTCCCTGACCTCCATCTTCAACAGC
GCCAGCACCCTCTTCACCATTGACCTCTACACCAAGATGCGGAAGCAAGCGTCGGAGAAA
GAGCTCCTGATAGCTGGACGGATATTTGTTCTTCTATTAACTGTTGTGAGCATTGTGTGG
GTCCCACTGGTACAAGTTTCTCAAAATGGACAACTAATCCATTACACAGAATCAATTTCT
AGCTACCTTGGGCCTCCAATTGCAGCTGTCTTTGTGCTTGCCATCTTCTGTAAAAGAGTC
AATGAACAGGGAGCATTCTGGGGTCTAATGGTTGGACTTGCAATGGGCCTCATTCGTATG
ATAACAGAGTTTGCTTATGGAACAGGGAGTTGCTTGGCTCCCAGTAACTGTCCCAAGATT
ATCTGTGGAGTGCACTATCTGTACTTTTCCATCGTTCTCTTTTTTGGGTCCATGCTGGTC
ACCCTGGGAATTTCCCTCTTAACAAAACCCATTCCTGATGTACATCTGTACCGCCTGTGC
TGGGTTCTTCGGAACAGTACAGAGGAGCGAATCGATATAGATGCAGAAGAGAAAAGTCAG
GAAGAAACAGATGATGGTGTTGAAGAAGATTATCCTGAGAAATCACGTGGATGCCTCAAG
AAAGCTTATGACTTGTTCTGCGGTTTGCAGAAGGGACCCAAGCTAACCAAGGAGGAGGAG
GAAGCCTTGAGCAAGAAGCTCACAGACACGTCTGAGAGGCCCTCGTGGAGGACAATAGTG
AACATCAACGCCATCCTCCTCCTGGCTGTGGTGGTCTTTATTCACGGCTACTATGCCTGA


# Macromolecular_Interacting_Partner_25_GenBank_ID_Gene:
AJ133127

# Macromolecular_Interacting_Partner_25_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_25_Locus:
22q12.2-q12.3

# Macromolecular_Interacting_Partner_25_SNPs:
rs2235171; rs16990065; rs12169024; rs5998322; rs2179065; rs2179066; rs7292721; rs2294208; rs8137034; rs2294207; rs5998317; rs8142488; rs5998318; rs5994512; rs6518765; rs5998338; rs7287853; rs2068209; rs8138638; rs5998328; rs5998321; rs7292474; rs7289147; rs5998326; rs7289531; rs7291681; rs5998327; rs7289226; rs2294206; rs5998323; rs5994508; rs2142559; rs2011900; rs5994511; rs2294209; rs2142558; rs9606920; rs2294205; rs5994503; rs17759199; rs5749360; rs5753895; rs2413090; rs7292027; rs16990052; rs9606921; rs2294211; rs5749359; rs2899178; rs5994502; rs5998319; rs5998330; rs2235168; rs5998329; rs5998337; rs9621415; rs9621409; rs5994505; rs7292337; rs734023; rs7292033; rs8136915; rs12167742; rs11089540; rs5994514; rs5998324; rs9621414; rs9619254; rs5998320; rs2294210; rs5998314; rs5753896; rs12160790; rs12157791; rs16990066; rs5998313; rs5998339; rs7292298; rs5844969; rs35225664; rs35413610; rs5753892; rs28623080; rs13058581; rs34985154; rs7287794; rs9621413; rs9680683; rs5994507; rs28542297; rs5998331; rs35927024; rs2235169; rs9621416; rs5998332; rs9619255; rs35747507; rs12170748; rs1040381; rs5998333; rs11703492; rs35777893; rs3069413; rs9606924; rs35029077; rs9621419; rs35616277; rs5994506; rs34804460; rs28723688; rs34959838; rs738206; rs5998336; rs5749358; rs5994499; rs9606922; rs5994513; rs5994509; rs12168670; rs34216419; rs34283566; rs12170744; rs5994510; rs7287176; rs35120843; rs9621411; rs5998334; rs35071283; rs35950285; rs36042592; rs5994500; rs12170617; rs9606923; rs5753891; rs34681388; rs35272467; rs2235170; rs36094105; rs35978586; rs5994504; rs35715246; rs10538190; rs12170621; rs3069416; rs12484627; rs34561454; rs12170692; rs9621407; rs35297945; rs5998312; rs9619253; rs11912118; rs12158446; rs12159802; rs12168696; rs1467388; rs1467389; rs4447695; rs5749357; rs5753898; rs5994496; rs5994498; rs5994515; rs5994516; rs5994517; rs5998307; rs5998347; rs5998351; rs5998352; rs5998353; rs5998354; rs5998355; rs5998356; rs5998359; rs713766; rs713784; rs713785; rs738203; rs8140253

# Macromolecular_Interacting_Partner_25_General_References:
10591208

# Macromolecular_Interacting_Partner_25_References:
17032938

# Macromolecular_Interacting_Partner_26_ID:
7839

# Macromolecular_Interacting_Partner_26_Name:
5'-AMP-activated protein kinase subunit beta-1

# Macromolecular_Interacting_Partner_26_Synonyms:
AMPK beta-1 chain; AMPKb

# Macromolecular_Interacting_Partner_26_Gene_Name:
PRKAB1

# Macromolecular_Interacting_Partner_26_Protein_Sequence:
>5'AMPactivated protein kinase subunit beta1
MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEF
LAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPE
GEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELS
SSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLY
ALSIKDGVMVLSATHRYKKKYVTTLLYKPI

# Macromolecular_Interacting_Partner_26_Number_of_Residues:
270

# Macromolecular_Interacting_Partner_26_Molecular_Weight:
30383

# Macromolecular_Interacting_Partner_26_Theoretical_pI:
6.37

# Macromolecular_Interacting_Partner_26_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_26_General_Function:
Not Available

# Macromolecular_Interacting_Partner_26_Specific_Function:
AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone- sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adaptor molecule for the catalytic alpha-subunit

# Macromolecular_Interacting_Partner_26_Pathway:
Not Available

# Macromolecular_Interacting_Partner_26_Reaction:
Not Available

# Macromolecular_Interacting_Partner_26_Pfam_Domain_Function:
PF04739:AMPKBI;
PF02922:Isoamylase_N

# Macromolecular_Interacting_Partner_26_Signals:
None

# Macromolecular_Interacting_Partner_26_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_26_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_26_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_26_GenBank_ID_Protein:
2916800

# Macromolecular_Interacting_Partner_26_SwissProt_ID:
AAKB1_HUMAN (Q9Y478)

# Macromolecular_Interacting_Partner_26_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_26_Genecard_id:
PRKAB1

# Macromolecular_Interacting_Partner_26_Geneatlas_id:
PRKAB1

# Macromolecular_Interacting_Partner_26_hgnc_id:
HGNC:9378

# Macromolecular_Interacting_Partner_26_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_26_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_26_Gene_Sequence:
>813 bp
ATGGGCAATACCAGCAGTGAGAGGGCGGCGCTGGAGCGGCATGCTGGCCATAAGACGCCC
CGGAGGGACAGCTCGGGGGGCACCAAGGACGGGGACAGGCCCAAGATCCTGATGGACAGC
CCCGAAGACGCCGACCTCTTCCACTCCGAGGAAATCAAGGCACCAGAGAAGGAGGAATTC
CTGGCCTGGCAGCATGATCTGGAAGTGAATGATAAAGCTCCCGCCCAGGCTCGGCCAACG
GTGTTTCGATGGACGGGGGGCGGAAAGGAAGTTTACTTATCTGGGTCCTTCAACAACTGG
AGTAAACTTCCCCTCACCAGAAGCCACAATAACTTTGTAGCCATCCTGGATCTGCCGGAA
GGAGAGCATCAGTACAAGTTCTTTGTGGATGGTCAGTGGACGCACGACCCTTCCGAGCCC
ATAGTAACCAGCCAGCTTGGCACAGTTAACAACATAATTCAAGTGAAGAAAACTGACTTT
GAGGTATTTGATGCTTTAATGGTGGATTCCCAAAAGTGCTCCGATGTGTCTGAGCTGTCC
AGTTCTCCCCCAGGACCCTACCATCAGGAGCCCTACGTCTGCAAACCCGAAGAGCGCTTT
CGGGCACCCCCTATTCTCCCCCCACATCTCCTCCAGGTCATCCTGAACAAGGACACGGGG
ATTTCCTGTGATCCAGCTTTGCTTCCTGAGCCCAATCACGTCATGCTGAACCACCTATAC
GCGCTGTCTATCAAGGATGGAGTGATGGTGCTCAGCGCAACCCACCGGTACAAGAAGAAG
TACGTCACCACCTTGTTATACAAGCCCATATGA

# Macromolecular_Interacting_Partner_26_GenBank_ID_Gene:
AJ224515

# Macromolecular_Interacting_Partner_26_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_26_Locus:
12q24.1

# Macromolecular_Interacting_Partner_26_SNPs:
rs4213; rs278148; rs278147; rs278149; rs278152; rs278143; rs6490267; rs278144; rs278145; rs10849690; rs17408578; rs278151; rs12314027; rs12304635; rs6490266; rs3759400; rs6490265; rs11064873; rs11546695; rs1043354; rs1062688; rs1043350; rs1043352; rs11064876; rs3182909; rs35934503; rs278146; rs278150; rs34309696; rs7312687; rs3999587; rs34549847; rs2285593; rs11832628; rs11064874; rs7953470; rs11064875; rs34516378; rs35524914; rs34062789; rs10774512; rs11064877; rs12305216; rs12425960; rs175878; rs1978107; rs1978108; rs2393550; rs278122; rs278123; rs278155; rs3742046; rs3930004; rs7300583; rs7310266; rs7953776; rs7960723

# Macromolecular_Interacting_Partner_26_General_References:
9224708

# Macromolecular_Interacting_Partner_26_References:
17026483; 17049164; 17082366; 17088252

# Macromolecular_Interacting_Partner_27_ID:
8500

# Macromolecular_Interacting_Partner_27_Name:
Solute carrier family 2, facilitated glucose transporter member 10

# Macromolecular_Interacting_Partner_27_Synonyms:
Glucose transporter type 10

# Macromolecular_Interacting_Partner_27_Gene_Name:
SLC2A10

# Macromolecular_Interacting_Partner_27_Protein_Sequence:
>Solute carrier family 2, facilitated glucose transporter member 10
MGHSPPVLPLCASVSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALL
ASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACC
IYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTPWGWRHMFGWATAPAVLQSL
SLLFLPAGTDETATHKDLIPLQGGEAPKLGPGRPRYSFLDLFRARDNMRGRTTVGLGLVL
FQQLTGQPNVLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALL
LAGCALMALSVSGIGLVSFAVPMDSGPSCLAVPNATGQTGLPGDSGLLQDSSLPPIPRTN
EDQREPILSTAKKTKPHPRSGDPSAPPRLALSSALPGPPLPARGHALLRWTALLCLMVFV
SAFSFGFGPVTWLVLSEIYPVEIRGRAFAFCNSFNWAANLFISLSFLDLIGTIGLSWTFL
LYGLTAVLGLGFIYLFVPETKGQSLAEIDQQFQKRRFTLSFGHRQNSTGIPYSRIEISAA
S

# Macromolecular_Interacting_Partner_27_Number_of_Residues:
541

# Macromolecular_Interacting_Partner_27_Molecular_Weight:
56912

# Macromolecular_Interacting_Partner_27_Theoretical_pI:
8.68

# Macromolecular_Interacting_Partner_27_GO_Classification:
>>>
 Function:  carrier activity
Function:  electrochemical potential-driven transporter activity
Function:  porter activity
Function:  sugar porter activity
Function:  transporter activity
 ||
>>>
 Process:  carbohydrate transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_27_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_27_Specific_Function:
Facilitative glucose transporter

# Macromolecular_Interacting_Partner_27_Pathway:
Not Available

# Macromolecular_Interacting_Partner_27_Reaction:
Not Available

# Macromolecular_Interacting_Partner_27_Pfam_Domain_Function:
PF00083:Sugar_tr

# Macromolecular_Interacting_Partner_27_Signals:
1-422

# Macromolecular_Interacting_Partner_27_Transmembrane_Regions:
16-36
49-69
78-98
107-127
135-155
167-187
234-254
270-290
299-319
415-435
446-466
477-497

# Macromolecular_Interacting_Partner_27_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_27_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_27_GenBank_ID_Protein:
13445575

# Macromolecular_Interacting_Partner_27_SwissProt_ID:
GTR10_HUMAN (O95528)

# Macromolecular_Interacting_Partner_27_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_27_Genecard_id:
SLC2A10

# Macromolecular_Interacting_Partner_27_Geneatlas_id:
SLC2A10

# Macromolecular_Interacting_Partner_27_hgnc_id:
HGNC:13444

# Macromolecular_Interacting_Partner_27_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_27_Subcellular_Location:
Intracytoplasmic membrane; multi-pass membrane protein. Cytoplasm; perinuclear region

# Macromolecular_Interacting_Partner_27_Gene_Sequence:
>1626 bp
ATGGGCCACTCCCCACCTGTCCTGCCTTTGTGTGCCTCTGTGTCTTTGCTGGGTGGCCTG
ACCTTTGGTTATGAACTGGCAGTCATATCAGGTGCCCTGCTGCCACTGCAGCTTGACTTT
GGGCTAAGCTGCTTGGAGCAGGAGTTCCTGGTGGGCAGCCTGCTCCTGGGGGCTCTCCTC
GCCTCCCTGGTTGGTGGCTTCCTCATTGACTGCTATGGCAGGAAGCAAGCCATCCTCGGG
AGCAACTTGGTGCTGCTGGCAGGCAGCCTGACCCTGGGCCTGGCTGGTTCCCTGGCCTGG
CTGGTCCTGGGCCGCGCTGTGGTTGGCTTCGCCATTTCCCTCTCCTCCATGGCTTGCTGT
ATCTACGTGTCAGAGCTGGTGGGGCCACGGCAGCGGGGAGTGCTGGTGTCCCTCTATGAG
GCAGGCATCACCGTGGGCATCCTGCTCTCCTATGCCCTCAACTATGCACTGGCTGGTACC
CCCTGGGGATGGAGGCACATGTTCGGCTGGGCCACTGCACCTGCTGTCCTGCAATCCCTC
AGCCTCCTCTTCCTCCCTGCTGGTACAGATGAGACTGCAACACACAAGGACCTCATCCCA
CTCCAGGGAGGTGAGGCCCCCAAGCTGGGCCCGGGGAGGCCACGGTACTCCTTTCTGGAC
CTCTTCAGGGCACGCGATAACATGCGAGGCCGGACCACAGTGGGCCTGGGGCTGGTGCTC
TTCCAGCAACTAACAGGGCAGCCCAACGTGCTGTGCTATGCCTCCACCATCTTCAGCTCC
GTTGGTTTCCATGGGGGATCCTCAGCCGTGCTGGCCTCTGTGGGGCTTGGCGCAGTGAAG
GTGGCAGCTACCCTGACCGCCATGGGGCTGGTGGACCGTGCAGGCCGCAGGGCTCTGTTG
CTAGCTGGCTGTGCCCTCATGGCCCTGTCCGTCAGTGGCATAGGCCTCGTCAGCTTTGCC
GTGCCCATGGACTCAGGCCCAAGCTGTCTGGCTGTGCCCAATGCCACCGGGCAGACAGGC
CTCCCTGGAGACTCTGGCCTGCTGCAGGACTCCTCTCTACCTCCCATTCCAAGGACCAAT
GAGGACCAAAGGGAGCCAATCTTGTCCACTGCTAAGAAAACCAAGCCCCATCCCAGATCT
GGAGACCCCTCAGCCCCTCCTCGGCTGGCCCTGAGCTCTGCCCTCCCTGGGCCCCCTCTG
CCCGCTCGGGGGCATGCACTGCTGCGCTGGACCGCACTGCTGTGCCTGATGGTCTTTGTC
AGTGCCTTCTCCTTTGGGTTTGGGCCAGTGACCTGGCTTGTCCTCAGCGAGATCTACCCT
GTGGAGATACGAGGAAGAGCCTTCGCCTTCTGCAACAGCTTCAACTGGGCGGCCAACCTC
TTCATCAGCCTCTCCTTCCTCGATCTCATTGGCACCATCGGCTTGTCCTGGACCTTCCTG
CTCTACGGACTGACCGCTGTCCTCGGCCTGGGCTTCATCTATTTATTTGTTCCTGAAACA
AAAGGCCAGTCGTTGGCAGAGATAGACCAGCAGTTCCAGAAGAGACGGTTCACCCTGAGC
TTTGGCCACAGGCAGAACTCCACTGGCATCCCGTACAGCCGCATCGAGATCTCTGCGGCC
TCCTGA

# Macromolecular_Interacting_Partner_27_GenBank_ID_Gene:
AF321240

# Macromolecular_Interacting_Partner_27_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_27_Locus:
20q13.1

# Macromolecular_Interacting_Partner_27_SNPs:
rs6018008; rs7348121; rs2235491; rs6094438; rs34295241; rs707507; rs1059217; rs1136540; rs1136544; rs6012025; rs6018010; rs2425911; rs3091904; rs998422; rs2425901; rs6017999; rs3091788; rs2425902; rs3092053; rs3092439; rs2425910; rs2425903; rs6512388; rs6124855; rs4239646; rs3091514; rs2425907; rs4810546; rs2143044; rs4809600; rs2076293; rs6512389; rs6017998; rs2425909; rs3092412; rs998423; rs760872; rs2425899; rs3091421; rs3091822; rs6012019; rs11086177; rs1122067; rs2425904; rs2425896; rs7272875; rs6018005; rs8119275; rs3092211; rs8114951; rs6018004; rs2425900; rs2425898; rs6018006; rs7267790; rs3091961; rs6012022; rs6017995; rs3092706; rs3091934; rs4810545; rs17861024; rs2425895; rs35151194; rs34605643; rs41283344; rs35833600; rs34990188; rs6094447; rs41283042; rs6094446; rs34912587; rs6066056; rs34965637; rs6094450; rs6094448; rs3091691; rs36103903; rs11541582; rs9046; rs6066055; rs6066057; rs6018009; rs6094449; rs35691491; rs35087171; rs11086179; rs11341417; rs8122241; rs6066049; rs3091474; rs2425897; rs6094443; rs6066050; rs35623541; rs6018007; rs7266228; rs6012020; rs3091944; rs6063017; rs3091554; rs35700088; rs6094441; rs6066052; rs6094445; rs7272321; rs6012024; rs10624698; rs6018002; rs6094437; rs11483528; rs2425906; rs35295123; rs6090544; rs6012021; rs3092014; rs34105557; rs7266179; rs6124853; rs36117506; rs6066047; rs6063016; rs35102875; rs6094442; rs6063018; rs35302720; rs6090545; rs11474416; rs8123413; rs11477202; rs6066051; rs6094440; rs6094439; rs6090543; rs34455275; rs12481018; rs13043534; rs6018001; rs34020691; rs11472342; rs6066053; rs6066054; rs6094436; rs11479560; rs11472815; rs35220320; rs8116529; rs34955100; rs6066046; rs6094444; rs4428069; rs34503605; rs6012023; rs35119522; rs10650846; rs6094435; rs2425894; rs6017994; rs36220016; rs11470362; rs11266962; rs1003513; rs1003514; rs11699610; rs11699667; rs12479748; rs12479945; rs16991799; rs2179357; rs2425893; rs2903953; rs3091537; rs3092621; rs4618107; rs4809599; rs4810542; rs4810543; rs6012017; rs6012026; rs6012028; rs6012029; rs6012030; rs6017989; rs6018015; rs6018016; rs6018018; rs6018019; rs6018020; rs6018021; rs6063019; rs6066058; rs6066059; rs6090546; rs6094451; rs6094455; rs7270203; rs7343687; rs737543; rs742321; rs8120698; rs8125934

# Macromolecular_Interacting_Partner_27_General_References:
11247674; 11780052

# Macromolecular_Interacting_Partner_27_References:
Not Available

# Macromolecular_Interacting_Partner_28_ID:
8536

# Macromolecular_Interacting_Partner_28_Name:
SLC5A10 protein

# Macromolecular_Interacting_Partner_28_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_28_Gene_Name:
SLC5A10

# Macromolecular_Interacting_Partner_28_Protein_Sequence:
>SLC5A10 protein
ANSTSDLHTPGTQLSVADIIVITVYFALNVAVGIWSSCRASRNTVNGYFLAGRDMTWWPI
GASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWNATYVLLALAWVFVPIYISSEIVTLPE
YIQKRYGGQRIRMYLSVLSLLLSVFTKISLDLYAGALFVHICLGWNFYLSTILTLGITAL
YTIAAFDQIGGYGQLEAAYAQAIPSRTIANTTCHLPRTDAMHMFRDPHTGDLPWTGMTFG
LTIMATWYWCTDQVIVQRSLSARDLNHAKAGSILASYLKMLPMGLIIMPGMISRALFPDD
VGCVVPSECLRACGAEVGCSNIAYPKLVMELMPIGLRGLMIAVMLAALMSSLTSIFNSSS
TLFTMDIWRRLRPRSGERELLLVGRLVIVALIGVSVAWIPVLQDSNSGQLFIYMQSVTSS
LAPPVTAVFVLGVFWRRANEQGAFWGLIAGLVVGATRLVLEFLNPAPPCGEPDTRPAVLG
SIHYLHFAVALFALSGAVVVAGSLLTPPPQSVQIENLTWWTLAQDVPLGTKAGDGQTPQK
HAFWARVCGFNAILLMCVNIFFYAYFA

# Macromolecular_Interacting_Partner_28_Number_of_Residues:
567

# Macromolecular_Interacting_Partner_28_Molecular_Weight:
61415

# Macromolecular_Interacting_Partner_28_Theoretical_pI:
7.67

# Macromolecular_Interacting_Partner_28_GO_Classification:
>>>
 Function:  transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_28_General_Function:
Not Available

# Macromolecular_Interacting_Partner_28_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_28_Pathway:
Not Available

# Macromolecular_Interacting_Partner_28_Reaction:
Not Available

# Macromolecular_Interacting_Partner_28_Pfam_Domain_Function:
PF00474:SSF

# Macromolecular_Interacting_Partner_28_Signals:
1-40

# Macromolecular_Interacting_Partner_28_Transmembrane_Regions:
15-37; 57-79; 94-116; 163-185; 232-249; 270-292; 338-360; 381-403; 413-435; 442-464; 484-506; 543-565

# Macromolecular_Interacting_Partner_28_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_28_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_28_GenBank_ID_Protein:
38511471

# Macromolecular_Interacting_Partner_28_SwissProt_ID:
Q6P5X0_HUMAN (Q6P5X0)

# Macromolecular_Interacting_Partner_28_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_28_Genecard_id:
SLC5A10

# Macromolecular_Interacting_Partner_28_Geneatlas_id:
SLC5A10

# Macromolecular_Interacting_Partner_28_hgnc_id:
HGNC:23155

# Macromolecular_Interacting_Partner_28_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_28_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_28_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_28_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_28_Gene_Sequence:
>1705 bp
CGCCAACTCCACCAGCGACCTCCACACTCCCGGGACGCAGCTGAGCGTGGCTGACATCAT
CGTCATCACTGTGTATTTTGCTCTGAATGTGGCCGTGGGCATATGGTCCTCTTGTCGGGC
CAGTAGGAACACGGTGAATGGCTACTTCCTGGCAGGCCGGGACATGACGTGGTGGCCGAT
TGGAGCCTCCCTCTTCGCCAGCAGCGAGGGCTCTGGCCTCTTCATTGGACTGGCGGGCTC
AGGCGCGGCAGGAGGTCTGGCCGTGGCAGGCTTCGAGTGGAATGCCACGTACGTGCTGCT
GGCACTGGCATGGGTGTTCGTGCCCATCTACATCTCCTCAGAGATCGTCACCTTACCTGA
GTACATTCAGAAGCGCTACGGGGGCCAGCGGATCCGCATGTACCTGTCTGTCCTGTCCCT
GCTACTGTCTGTCTTCACCAAGATATCGCTGGACCTGTACGCGGGGGCTCTGTTTGTGCA
CATCTGCCTGGGCTGGAACTTCTACCTCTCCACCATCCTCACGCTCGGCATCACAGCCCT
GTACACCATCGCAGCTTTTGACCAGATCGGTGGTTACGGGCAGCTGGAGGCAGCCTACGC
CCAGGCCATTCCCTCCAGGACCATTGCCAACACCACCTGCCACCTGCCACGTACAGACGC
CATGCACATGTTTCGAGACCCCCACACAGGGGACCTGCCGTGGACCGGGATGACCTTTGG
CCTGACCATCATGGCCACCTGGTACTGGTGCACCGACCAGGTCATCGTGCAGCGATCACT
GTCAGCCCGGGACCTGAACCATGCCAAGGCGGGCTCCATCCTGGCCAGCTACCTCAAGAT
GCTCCCCATGGGCCTGATCATCATGCCGGGCATGATCAGCCGCGCATTGTTCCCAGATGA
TGTGGGCTGCGTGGTGCCGTCCGAGTGCCTGCGGGCCTGCGGGGCCGAGGTCGGCTGCTC
CAACATCGCCTACCCCAAGCTGGTCATGGAACTGATGCCCATCGGTCTGCGGGGGCTGAT
GATCGCAGTGATGCTGGCGGCGCTCATGTCGTCGCTGACCTCCATCTTCAACAGCAGCAG
CACCCTCTTCACTATGGACATCTGGAGGCGGCTGCGTCCCCGCTCCGGCGAGCGGGAGCT
CCTGCTGGTGGGACGGCTGGTCATAGTGGCACTCATCGGCGTGAGTGTGGCCTGGATCCC
CGTCCTGCAGGACTCCAACAGCGGGCAACTCTTCATCTACATGCAGTCAGTGACCAGCTC
CCTGGCCCCACCAGTGACTGCAGTCTTTGTCCTGGGCGTCTTCTGGCGACGTGCCAACGA
GCAGGGGGCCTTCTGGGGCCTGATAGCAGGGCTGGTGGTGGGGGCCACGAGGCTGGTCCT
GGAATTCCTGAACCCAGCCCCACCGTGCGGAGAGCCAGACACGCGGCCAGCCGTCCTGGG
GAGCATCCACTACCTGCACTTCGCTGTCGCCCTCTTTGCACTCAGTGGTGCTGTTGTGGT
GGCTGGAAGCCTGCTGACCCCACCCCCACAGAGTGTCCAGATTGAGAACCTTACCTGGTG
GACCCTGGCTCAGGATGTGCCCTTGGGAACTAAAGCAGGTGATGGCCAAACACCCCAGAA
ACACGCCTTCTGGGCCCGTGTCTGTGGCTTCAATGCCATCCTCCTCATGTGTGTCAACAT
ATTCTTTTATGCCTACTTCGCCTGA

# Macromolecular_Interacting_Partner_28_GenBank_ID_Gene:
BC062617

# Macromolecular_Interacting_Partner_28_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_28_Locus:
17p11.2

# Macromolecular_Interacting_Partner_28_SNPs:
rs2074279; rs2076562; rs2428379; rs4924949; rs7207513; rs7216663; rs2469842; rs11653983; rs2472691; rs9303159; rs7226255; rs2073078; rs9903337; rs1634413; rs2472693; rs8068094; rs2258367; rs2472692; rs11651570; rs1634416; rs2469843; rs7208220; rs2469847; rs2428375; rs2074275; rs8415; rs11652123; rs2074276; rs8073914; rs916823; rs8070971; rs12450886; rs17842752; rs3751970; rs3751969; rs2472707; rs12453523; rs12453564; rs2428369; rs2472719; rs2428376; rs2428371; rs2469845; rs11078427; rs2472708; rs2074280; rs11652575; rs2428370; rs12450520; rs17718627; rs2074281; rs2257609; rs11654290; rs2472710; rs2428372; rs2074272; rs1076203; rs4924950; rs9895133; rs2074273; rs2472709; rs1555142; rs1634418; rs1634417; rs12604020; rs28582882; rs1737945; rs11652176; rs10572143; rs11428721; rs11656746; rs10606920; rs34117189; rs1737946; rs1634414; rs7208785; rs10525201; rs2428378; rs11656645; rs8064437; rs10532839; rs36041055; rs1634415; rs9898417; rs11656642; rs10533006; rs34638037; rs35545653; rs35838018; rs8078103; rs36006919; rs11269799; rs3180910; rs34809691; rs12603640; rs34535827; rs34684464; rs12940928; rs2074278; rs12940947; rs2469846; rs9904265; rs11375864; rs35475444; rs11309887; rs12938841; rs34744898; rs28474381; rs34150297; rs2428373; rs28463694; rs2074282; rs9899204; rs36021973; rs35121271; rs9916283; rs2469844; rs34229689; rs1978126; rs35947526; rs2106851; rs28526726; rs3071666; rs12939071; rs11269374; rs11305580; rs9891254; rs34417477; rs2428377; rs2074274; rs34472502; rs12938817; rs36060906; rs1634420; rs1634419; rs35249728; rs35140082; rs7215284; rs10451246; rs11649710; rs11652364; rs11652366; rs11656760; rs11656765; rs11868888; rs12450425; rs12451868; rs1611882; rs1634421; rs17842753; rs17842754; rs2074270; rs2074271; rs2074277; rs2074283; rs2428374; rs2469860; rs2469861; rs2472694; rs2472713; rs2472714; rs2472715; rs2472716; rs2472717; rs35367461; rs35678611; rs6502681; rs7211874; rs7218569; rs731996; rs8064539; rs8069879; rs8070612; rs8070758; rs8077103; rs885675; rs886283; rs886284; rs9893211; rs9901327

# Macromolecular_Interacting_Partner_28_General_References:
12477932

# Macromolecular_Interacting_Partner_28_References:
Not Available

# Macromolecular_Interacting_Partner_29_ID:
8567

# Macromolecular_Interacting_Partner_29_Name:
Solute carrier family 2, facilitated glucose transporter member 11

# Macromolecular_Interacting_Partner_29_Synonyms:
Glucose transporter type 11; Glucose transporter type 10

# Macromolecular_Interacting_Partner_29_Gene_Name:
SLC2A11

# Macromolecular_Interacting_Partner_29_Protein_Sequence:
>Solute carrier family 2, facilitated glucose transporter member 11
MRALRRLIQGRILLLTICAAGIGGTFQFGYNLSIINAPTLHIQEFTNETWQARTGEPLPD
HLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRKAGS
FEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVVGLRE
LLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEACLAALRRLRGSGDLA
GELEELEEERAACQGCRARRPWELFQHRALRRQVTSLVVLGSAMELCGNDSVYAYASSVF
RKAGVPEAKIQYAIIGTGSCELLTAVVSCVVIERVGRRVLLIGGYSLMTCWGSIFTVALC
LQSSFPWTLYLAMACIFAFILSFGIGPAGVTGILATELFDQMARPAACMVCGALMWIMLI
LVGLGFPFIMEALSHFLYVPFLGVCVCGAIYTGLFLPETKGKTFQEISKELHRLNFPRRA
QGPTWRSLEVIQSTEL

# Macromolecular_Interacting_Partner_29_Number_of_Residues:
496

# Macromolecular_Interacting_Partner_29_Molecular_Weight:
53704

# Macromolecular_Interacting_Partner_29_Theoretical_pI:
8.23

# Macromolecular_Interacting_Partner_29_GO_Classification:
>>>
 Function:  carrier activity
Function:  electrochemical potential-driven transporter activity
Function:  porter activity
Function:  sugar porter activity
Function:  transporter activity
Function:  carbohydrate transporter activity
Function:  sugar transporter activity
Function:  monosaccharide transporter activity
Function:  hexose transporter activity
Function:  glucose transporter activity
 ||
>>>
 Process:  carbohydrate transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_29_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_29_Specific_Function:
Facilitative glucose transporter

# Macromolecular_Interacting_Partner_29_Pathway:
Not Available

# Macromolecular_Interacting_Partner_29_Reaction:
Not Available

# Macromolecular_Interacting_Partner_29_Pfam_Domain_Function:
PF00083:Sugar_tr

# Macromolecular_Interacting_Partner_29_Signals:
1-24

# Macromolecular_Interacting_Partner_29_Transmembrane_Regions:
12-32
62-82
98-118
129-149
158-178
188-208
274-294
312-332
339-359
365-385
409-429
436-456

# Macromolecular_Interacting_Partner_29_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_29_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_29_GenBank_ID_Protein:
12802047

# Macromolecular_Interacting_Partner_29_SwissProt_ID:
GTR11_HUMAN (Q9BYW1)

# Macromolecular_Interacting_Partner_29_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_29_Genecard_id:
SLC2A11

# Macromolecular_Interacting_Partner_29_Geneatlas_id:
SLC2A11

# Macromolecular_Interacting_Partner_29_hgnc_id:
HGNC:14239

# Macromolecular_Interacting_Partner_29_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_29_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_29_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_29_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_29_Gene_Sequence:
>1491 bp
ATGAGAGCGCTCCGAAGACTGATTCAGGGCAGGATCCTGCTCCTGACCATCTGCGCTGCC
GGCATTGGTGGGACTTTTCAGTTTGGCTATAACCTCTCTATCATCAATGCCCCGACCTTG
CACATTCAGGAATTCACCAATGAGACATGGCAGGCGCGTACTGGAGAGCCACTGCCCGAT
CACCTAGTCCTGCTTATGTGGTCCCTCATCGTGTCTCTGTATCCCCTGGGAGGCCTCTTT
GGAGCACTGCTTGCAGGTCCCTTGGCCATCACGCTGGGAAGGAAGAAGTCCCTCCTGGTG
AATAACATCTTTGTGGTGTCAGCAGCAATCCTGTTTGGATTCAGCCGCAAAGCAGGCTCC
TTTGAGATGATCATGCTGGGAAGACTGCTCGTGGGAGTCAATGCAGGTGTGAGCATGAAC
ATCCAGCCCATGTACCTGGGGGAGAGCGCCCCTAAGGAGCTCCGAGGAGCTGTGGCCATG
AGCTCAGCCATCTTTACGGCTCTGGGGATCGTGATGGGACAGGTGGTCGGACTCAGGGAG
CTCCTAGGTGGCCCTCAGGCCTGGCCCCTGCTGCTGGCCAGCTGCCTGGTGCCCGGGGCG
CTCCAGCTCGCCTCCCTGCCTCTGCTCCCTGAAAGCCCGCGCTACCTCCTCATTGACTGT
GGAGACACCGAGGCCTGCCTGGCAGCACTACGGCGGCTCCGGGGCTCCGGGGACTTGGCA
GGGGAGCTGGAGGAGCTGGAGGAGGAGCGCGCTGCCTGCCAGGGCTGCCGTGCCCGGCGC
CCATGGGAGCTGTTCCAGCATCGGGCCCTGAGGAGACAGGTGACAAGCCTCGTGGTTCTG
GGCAGTGCCATGGAGCTCTGCGGGAATGACTCGGTGTACGCCTACGCCTCCTCCGTGTTC
CGGAAGGCAGGAGTGCCGGAAGCGAAGATCCAGTACGCGATCATCGGGACTGGGAGCTGC
GAGCTGCTCACGGCGGTTGTTAGTTGTGTGGTAATCGAGAGGGTGGGTCGGCGCGTGCTG
CTCATCGGTGGGTACAGCCTGATGACCTGCTGGGGGAGCATCTTCACTGTGGCCCTGTGC
CTGCAGAGCTCCTTCCCCTGGACACTCTACCTGGCCATGGCCTGCATCTTTGCCTTCATC
CTCAGCTTTGGCATTGGCCCTGCCGGAGTGACGGGGATCCTGGCCACAGAGCTGTTTGAC
CAGATGGCCAGGCCTGCTGCCTGCATGGTCTGCGGGGCGCTCATGTGGATCATGCTCATC
CTGGTCGGCCTGGGATTTCCCTTTATCATGGAGGCCTTGTCCCACTTCCTCTATGTCCCT
TTCCTTGGTGTCTGTGTCTGTGGGGCCATCTACACTGGCCTGTTCCTTCCTGAGACCAAA
GGCAAGACCTTCCAAGAGATCTCCAAGGAATTACACAGACTCAACTTCCCCAGGCGGGCC
CAGGGCCCCACGTGGAGGAGCCTGGAGGTTATCCAGTCAACAGAACTCTAG

# Macromolecular_Interacting_Partner_29_GenBank_ID_Gene:
AJ271290

# Macromolecular_Interacting_Partner_29_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_29_Locus:
22q11.2

# Macromolecular_Interacting_Partner_29_SNPs:
rs9608213; rs16986337; rs34096096; rs2298376; rs36026871; rs9612499; rs6003939; rs9680524; rs17637865; rs2236620; rs2236621; rs2236619; rs6003933; rs4822441; rs2070460; rs11913427; rs2330625; rs9612496; rs738805; rs11912846; rs1003784; rs6003934; rs4822442; rs6519481; rs9612492; rs5760076; rs2330626; rs9612498; rs1018743; rs2275979; rs17550765; rs12157360; rs4428104; rs7354788; rs17550723; rs11913367; rs7292463; rs5751756; rs11914192; rs6003938; rs17004024; rs17004019; rs9608209; rs7285765; rs9612497; rs5760077; rs41534446; rs12628753; rs7285454; rs17004022; rs12628690; rs7290765; rs11913302; rs17004025; rs8137150; rs12627775; rs6003932; rs11913444; rs12159879; rs2154603; rs7510757; rs17004023; rs12628741; rs12628669; rs5760075; rs10154701; rs10154693; rs10154254; rs10154251; rs10154686; rs10154690; rs10154820; rs36015336; rs34605560; rs7292659; rs28538596; rs41277537; rs5760085; rs28394628; rs5760078; rs7284944; rs35530255; rs9620328; rs35460600; rs6003929; rs9608212; rs11324208; rs35771312; rs9612500; rs11913370; rs13055321; rs11704904; rs35211513; rs5760081; rs7288166; rs11457708; rs5844571; rs34657507; rs35137003; rs28551475; rs3831378; rs28651695; rs34976780; rs5996622; rs34398393; rs9608210; rs35473369; rs28438809; rs9608211; rs28456332; rs11913035; rs36101447; rs6003930; rs12172122; rs9612494; rs12160594; rs12160730; rs6003928; rs2298377; rs12172187; rs9608214; rs33955414; rs11273439; rs11913369; rs34323650; rs34441283; rs11284722; rs35262791; rs35173398; rs10570243; rs6003936; rs35970936; rs5751758; rs34697982; rs5760082; rs34629204; rs35177865; rs5760079; rs9612493; rs34729941; rs11393545; rs11913066; rs5996624; rs11455226; rs35493116; rs13057272; rs35108939; rs5760080; rs11457707; rs5760083; rs34068482; rs34192462; rs12159857; rs5760086; rs9680799; rs28421983; rs9754465; rs35420058; rs5996625; rs9754325; rs9680876; rs9754322; rs9754323; rs9680685; rs9680785; rs28636037; rs9754326; rs28374369; rs10427712; rs10427750; rs1049829; rs1050605; rs1129067; rs12485058; rs12628766; rs1803649; rs1803976; rs1984309; rs2070766; rs2096525; rs3191127; rs4820568; rs4822443; rs4822444; rs4822445; rs4822446; rs4822447; rs4822449; rs5751759; rs5760071; rs5760088; rs5760090; rs5996627; rs7287669; rs738802; rs738803; rs738804; rs738806; rs738807; rs755622; rs8140004; rs8141314; rs875643; rs9282783; rs9608207; rs9612490; rs9612503

# Macromolecular_Interacting_Partner_29_General_References:
11741323

# Macromolecular_Interacting_Partner_29_References:
Not Available

# Macromolecular_Interacting_Partner_30_ID:
8627

# Macromolecular_Interacting_Partner_30_Name:
4F2 cell-surface antigen heavy chain

# Macromolecular_Interacting_Partner_30_Synonyms:
4F2hc; Lymphocyte activation antigen 4F2 large subunit; 4F2 heavy chain antigen; CD98 antigen

# Macromolecular_Interacting_Partner_30_Gene_Name:
SLC3A2

# Macromolecular_Interacting_Partner_30_Protein_Sequence:
>4F2 cellsurface antigen heavy chain
MSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKF
TGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHT
GALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQID
PNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAG
VDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLT
SSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLP
GTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLS
LFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQAS
DLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYAA

# Macromolecular_Interacting_Partner_30_Number_of_Residues:
529

# Macromolecular_Interacting_Partner_30_Molecular_Weight:
57945

# Macromolecular_Interacting_Partner_30_Theoretical_pI:
4.99

# Macromolecular_Interacting_Partner_30_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  amylase activity
Function:  alpha-amylase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_30_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_30_Specific_Function:
Involved in sodium-independent, high-affinity transport of large neutral amino acids. Required for normal and neoplastic cell growth

# Macromolecular_Interacting_Partner_30_Pathway:
Not Available

# Macromolecular_Interacting_Partner_30_Reaction:
Not Available

# Macromolecular_Interacting_Partner_30_Pfam_Domain_Function:
PF00128:Alpha-amylase

# Macromolecular_Interacting_Partner_30_Signals:
1-98

# Macromolecular_Interacting_Partner_30_Transmembrane_Regions:
82-104

# Macromolecular_Interacting_Partner_30_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_30_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_30_GenBank_ID_Protein:
182865

# Macromolecular_Interacting_Partner_30_SwissProt_ID:
4F2_HUMAN (P08195)

# Macromolecular_Interacting_Partner_30_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_30_Genecard_id:
SLC3A2

# Macromolecular_Interacting_Partner_30_Geneatlas_id:
SLC3A2

# Macromolecular_Interacting_Partner_30_hgnc_id:
HGNC:11026

# Macromolecular_Interacting_Partner_30_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_30_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_30_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_30_Subcellular_Location:
Membrane; single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Macromolecular_Interacting_Partner_30_Gene_Sequence:
>1590 bp
ATGAGCCAGGACACCGAGGTGGATATGAAGGAGGTGGAGCTGAATGAGTTAGAGCCCGAG
AAGCAGCCGATGAACGCGGCGTCTGGGGCGGCCATGTCCCTGGCGGGAGCCGAGAAGAAT
GGTCTGGTGAAGATCAAGGTGGCGGAAGACGAGGCGGAGGCGGCAGCCGCGGCTAAGTTC
ACGGGCCTGTCCAAGGAGGAGCTGCTGAAGGTGGCAGGCAGCCCCGGCTGGGTACGCACC
CGCTGGGCACTGCTGCTGCTCTTCTGGCTCGGCTGGCTCGGCATGCTTGCTGGTGCCGTG
GTCATAATCGTGCGAGCGCCGCGTTGTCGCGAGCTACCGGCGCAGAAGTGGTGGCACACG
GGCGCCCTCTACCGCATCGGCGACCTTCAGGCCTTCCAGGGCCACGGCGCGGGCAACCTG
GCGGGTCTGAAGGGGCGTCTCGATTACCTGAGCTCTCTGAAGGTGAAGGGCCTTGTGCTG
GGTCCAATTCACAAGAACCAGAAGGATGATGTCGCTCAGACTGACTTGCTGCAGATCGAC
CCCAATTTTGGCTCCAAGGAAGATTTTGACAGTCTCTTGCAATCGGCTAAAAAAAAGAGC
ATCCGTGTCATTCTGGACCTTACTCCCAACTACCGGGGTGAGAACTCGTGGTTCTCCACT
CAGGTTGACACTGTGGCCACCAAGGTGAAGGATGCTCTGGAGTTTTGGCTGCAAGCTGGC
GTGGATGGGTTCCAGGTTCGGGACATAGAGAATCTGAAGGATGCATCCTCATTCTTGGCT
GAGTGGCAAAATATCACCAAGGGCTTCAGTGAAGACAGGCTCTTGATTGCGGGGACTAAC
TCCTCCGACCTTCAGCAGATCCTGAGCCTACTCGAATCCAACAAAGACTTGCTGTTGACT
AGCTCATACCTGTCTGATTCTGGTTCTACTGGGGAGCATACAAAATCCCTAGTCACACAG
TATTTGAATGCCACTGGCAATCGCTGGTGCAGCTGGAGTTTGTCTCAGGCAAGGCTCCTG
ACTTCCTTCTTGCCGGCTCAACTTCTCCGACTCTACCAGCTGATGCTCTTCACCCTGCCA
GGGACCCCTGTTTTCAGCTACGGGGATGAGATTGGCCTGGATGCAGCTGCCCTTCCTGGA
CAGCCTATGGAGGCTCCAGTCATGCTGTGGGATGAGTCCAGCTTCCCTGACATCCCAGGG
GCTGTAAGTGCCAACATGACTGTGAAGGGCCAGAGTGAAGACCCTGGCTCCCTCCTTTCC
TTGTTCCGGCGGCTGAGTGACCAGCGGAGTAAGGAGCGCTCCCTACTGCATGGGGACTTC
CACGCGTTCTCCGCTGGGCCTGGACTCTTCTCCTATATCCGCCACTGGGACCAGAATGAG
CGTTTTCTGGTAGTGCTTAACTTTGGGGATGTGGGCCTCTCGGCTGGACTGCAGGCCTCC
GACCTGCCTGCCAGCGCCAGCCTCCCAGCCAAGGCTGACCTCCTGCTCAGCACCCAGCCA
GGCCGTGAGGAGGGCTCCCCTCTTGAGCTGGAACGCCTGAAACTGGAGCCTCACGAAGGG
CTGCTGCTCCGCTTCCCCTACGCGGCCTGA

# Macromolecular_Interacting_Partner_30_GenBank_ID_Gene:
J02939

# Macromolecular_Interacting_Partner_30_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_30_Locus:
11q13

# Macromolecular_Interacting_Partner_30_SNPs:
rs4726; rs6932; rs489381; rs10897300; rs10897301; rs10792362; rs3809075; rs12221878; rs481235; rs12577251; rs4567465; rs12794763; rs7104190; rs507101; rs7106901; rs12098955; rs561385; rs519473; rs12804553; rs12274689; rs7935096; rs2070870; rs2920155; rs2282477; rs1140538; rs7944051; rs3015957; rs11548759; rs1051342; rs11548756; rs1051289; rs1051290; rs1802910; rs1051237; rs1802911; rs11548760; rs1051285; rs12272749; rs35228448; rs540791; rs549706; rs11231260; rs543622; rs541444; rs34047097; rs35246991; rs1815840; rs3840765; rs11231257; rs544453; rs35881347; rs35320203; rs2957168; rs7130029; rs519425; rs541388; rs34176851; rs535854; rs35091612; rs7106895; rs2096559; rs473815; rs11318751; rs5792273; rs12797676; rs499294; rs34225665; rs3809074; rs2957166; rs7115838; rs12803557; rs521939; rs1938675; rs563394; rs1300138; rs12225962; rs2105515; rs36034735; rs486306; rs12788771; rs1212628; rs1286159; rs5792274; rs12794229; rs7117639; rs495776; rs11231259; rs12366036; rs509327; rs35657900; rs11231261; rs496788; rs35988334; rs12788770; rs34335071; rs1298673; rs766316; rs34722625; rs560603; rs11824602; rs565303; rs34494671; rs35455481; rs7101685; rs1286160; rs510307; rs12270563; rs11231254; rs11231262; rs11318752; rs549635; rs12270604; rs2957167; rs11317361; rs7126772; rs34436839; rs11341257; rs577134; rs11558674; rs1059292; rs11231249; rs11231250; rs12270342; rs12295052; rs1785940; rs2071036; rs2269353; rs2507820; rs2509678; rs2510083; rs3737388; rs3737389; rs4034; rs480730; rs493851; rs498751; rs524891; rs547248; rs560006

# Macromolecular_Interacting_Partner_30_General_References:
3476959; 3036867; 3480538; 3265470; 12754519; 11840567; 12270127

# Macromolecular_Interacting_Partner_30_References:
Not Available

# Macromolecular_Interacting_Partner_31_ID:
8661

# Macromolecular_Interacting_Partner_31_Name:
Solute carrier family 5

# Macromolecular_Interacting_Partner_31_Synonyms:
Sodium/glucose cotransporter, member 9

# Macromolecular_Interacting_Partner_31_Gene_Name:
SLC5A9

# Macromolecular_Interacting_Partner_31_Protein_Sequence:
>Solute carrier family 5
MGPGASGDGVRTETAPHIALDSRVGLHAYDISVVVIYFVFVIAVGIWSSIRASRGTIGGY
FLAGRSMSWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEWNMRKSRSGGDRGIHP
RSHGRTGVRSQATWLLLALGWVFVPVYIAAGVVTMPQYLKKRFGGQRIQVYMSVLSLILY
IFTKISTDIFSGALFIQMALGWNLYLSTGILLVVTAVYTIAGGLMAVIYTDALQTVIMVG
GALVLMFLGFQDVGWYPGLEQRYRQAIPNVTVPNTTCHLPRPDAFHILRDPVSGDIPWPG
LIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRAL
FPDEVGCVDPDVCQRICGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIF
NSSSTLFTIDVWQRFRRKSTEQELMVVGRVFVVFLVVISILWIPIIQSSNSGQLFDYIQA
VTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRMILEFSYPAPACGEVDRRP
AVLKDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTRLTWWTRNCPLSELEKEAHES
TPEISERPAGECPAGGGAAENSSLGQEQPEAPSRSWGKLLWSWFCGLSGTPEQALSPAEK
AALEQKLTSIEEEPLWRHVCNINAVLLLAINIFLWGYFA

# Macromolecular_Interacting_Partner_31_Number_of_Residues:
699

# Macromolecular_Interacting_Partner_31_Molecular_Weight:
76101

# Macromolecular_Interacting_Partner_31_Theoretical_pI:
8.16

# Macromolecular_Interacting_Partner_31_GO_Classification:
>>>
 Function:  transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_31_General_Function:
Not Available

# Macromolecular_Interacting_Partner_31_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_31_Pathway:
Not Available

# Macromolecular_Interacting_Partner_31_Reaction:
Not Available

# Macromolecular_Interacting_Partner_31_Pfam_Domain_Function:
PF00474:SSF

# Macromolecular_Interacting_Partner_31_Signals:
1-150

# Macromolecular_Interacting_Partner_31_Transmembrane_Regions:
28-50; 81-103; 131-153; 174-196; 206-228; 233-255; 296-313; 334-356; 402-424; 445-467; 477-499; 506-528; 548-570; 679-698

# Macromolecular_Interacting_Partner_31_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_31_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_31_GenBank_ID_Protein:
56203824

# Macromolecular_Interacting_Partner_31_SwissProt_ID:
Q5TET3_HUMAN (Q5TET3)

# Macromolecular_Interacting_Partner_31_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_31_Genecard_id:
SLC5A9

# Macromolecular_Interacting_Partner_31_Geneatlas_id:
SLC5A9

# Macromolecular_Interacting_Partner_31_hgnc_id:
HGNC:22146

# Macromolecular_Interacting_Partner_31_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_31_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_31_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_31_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_31_Gene_Sequence:
>2100 bp
ATGGGGCCTGGAGCTTCAGGGGACGGGGTCAGGACTGAGACAGCTCCACACATAGCACTG
GACTCCAGAGTTGGTCTGCACGCCTACGACATCAGCGTGGTGGTCATCTACTTTGTCTTC
GTCATTGCTGTGGGGATCTGGTCGTCCATCCGTGCAAGTCGAGGGACCATTGGCGGCTAT
TTCCTGGCCGGGAGGTCCATGAGCTGGTGGCCAATTGGAGCATCTCTGATGTCCAGCAAT
GTGGGCAGTGGCTTGTTCATCGGCCTGGCTGGGACAGGGGCTGCCGGAGGCCTTGCCGTA
GGTGGCTTCGAGTGGAACATGAGGAAATCAAGGTCTGGAGGAGACAGAGGGATCCATCCA
AGGTCACACGGGAGGACTGGGGTCAGGTCCCAGGCAACCTGGCTGCTCCTGGCCCTTGGC
TGGGTCTTCGTCCCTGTGTACATCGCAGCAGGTGTGGTCACAATGCCGCAGTATCTGAAG
AAGCGATTTGGGGGCCAGAGGATCCAGGTGTACATGTCTGTCCTGTCTCTCATCCTCTAC
ATCTTCACCAAGATCTCGACTGACATCTTCTCTGGAGCCCTCTTCATCCAGATGGCATTG
GGCTGGAACCTGTACCTCTCCACAGGGATCCTGCTGGTGGTGACTGCCGTCTACACCATT
GCAGGTGGCCTCATGGCCGTGATCTACACAGATGCTCTGCAGACGGTGATCATGGTAGGG
GGAGCCCTGGTCCTCATGTTTCTGGGCTTTCAGGACGTGGGCTGGTACCCAGGCCTGGAG
CAGCGGTACAGGCAGGCCATCCCTAATGTCACAGTCCCCAACACCACCTGTCACCTCCCA
CGGCCCGATGCTTTCCACATTCTTCGGGACCCTGTGAGCGGGGACATCCCTTGGCCAGGT
CTCATTTTCGGGCTCACAGTGCTGGCCACCTGGTGTTGGTGCACAGACCAGGTCATTGTG
CAGCGGTCTCTCTCGGCCAAGAGTCTGTCTCATGCCAAGGGAGGCTCCGTGCTGGGGGGC
TACCTGAAGATCCTCCCCATGTTCTTCATCGTCATGCCTGGCATGATCAGCCGGGCCCTG
TTCCCAGACGAGGTGGGCTGCGTGGACCCTGATGTCTGCCAAAGAATCTGTGGGGCCCGA
GTGGGATGTTCCAACATTGCCTACCCTAAGTTGGTCATGGCCCTCATGCCTGTTGGTCTG
CGGGGGCTGATGATTGCCGTGATCATGGCCGCTCTCATGAGCTCACTCACCTCCATCTTC
AACAGCAGCAGCACCCTGTTCACCATTGATGTGTGGCAGCGCTTCCGCAGGAAGTCAACA
GAGCAGGAGCTGATGGTGGTGGGCAGAGTGTTTGTGGTGTTCCTGGTTGTCATCAGCATC
CTCTGGATCCCCATCATCCAAAGCTCCAACAGTGGGCAGCTCTTCGACTACATCCAGGCT
GTCACCAGTTACCTGGCCCCACCCATCACCGCTCTCTTCCTGCTGGCCATCTTCTGCAAG
AGGGTCACAGAGCCCGGAGCTTTCTGGGGCCTCGTGTTTGGCCTGGGAGTGGGGCTTCTG
CGTATGATCCTGGAGTTCTCATACCCAGCGCCAGCCTGTGGGGAGGTGGACCGGAGGCCA
GCAGTGCTGAAGGACTTCCACTACCTGTACTTTGCAATCCTCCTCTGCGGGCTCACTGCC
ATCGTCATTGTCATTGTCAGCCTCTGTACAACTCCCATCCCTGAGGAACAGCTCACACGC
CTCACATGGTGGACTCGGAACTGCCCCCTCTCTGAGCTGGAGAAGGAGGCCCACGAGAGC
ACACCGGAGATATCCGAGAGGCCAGCCGGGGAGTGCCCTGCAGGAGGTGGAGCGGCAGAG
AACTCGAGCCTGGGCCAGGAGCAGCCTGAAGCCCCAAGCAGGTCCTGGGGAAAGTTGCTC
TGGAGCTGGTTCTGTGGGCTCTCTGGAACACCGGAGCAGGCCCTGAGCCCAGCAGAGAAG
GCTGCGCTAGAACAGAAGCTGACAAGCATTGAGGAGGAGCCACTCTGGAGACATGTCTGC
AACATCAATGCTGTCCTTTTGCTGGCCATCAACATCTTCCTCTGGGGCTATTTTGCGTGA


# Macromolecular_Interacting_Partner_31_GenBank_ID_Gene:
AL109659

# Macromolecular_Interacting_Partner_31_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_31_Locus:
1p33

# Macromolecular_Interacting_Partner_31_SNPs:
rs850763; rs212989; rs12047252; rs212991; rs986027; rs2275698; rs1005538; rs2137831; rs4926518; rs11205458; rs11205459; rs764656; rs4926721; rs6670286; rs10788884; rs540944; rs12139099; rs4926720; rs12043455; rs12563106; rs7413497; rs6685450; rs11807747; rs2354005; rs1004833; rs705430; rs11809119; rs10888600; rs12126047; rs12118417; rs11205460; rs10489600; rs6694372; rs17104309; rs172480; rs212987; rs212986; rs6695408; rs12040115; rs12161316; rs7535096; rs41287930; rs41287932; rs17104299; rs12069452; rs12744691; rs11800306; rs36026942; rs28559882; rs12744574; rs35442116; rs177111; rs12123480; rs5773996; rs28548080; rs12119362; rs12130095; rs12081921; rs34216216; rs7554493; rs28637099; rs41287918; rs34855469; rs12738451; rs7415392; rs36053829; rs483937; rs1524734; rs12161552; rs5773999; rs28380281; rs35238707; rs7556499; rs34463054; rs35278010; rs35274475; rs41341650; rs28495806; rs5773998; rs212990; rs212988; rs35687593; rs34525597; rs7413495; rs35719528; rs34762012; rs12746335; rs41287922; rs12039311; rs34370455; rs34004627; rs212972; rs11205461; rs12026864; rs34445433; rs212984; rs212985; rs12746902; rs6695277; rs10430109; rs41287916; rs34039663; rs10788883; rs11205457; rs11802676; rs12081912; rs12120330; rs12739960; rs1524732; rs169880; rs1740106; rs1740107; rs212959; rs212961; rs212962; rs212963; rs212964; rs212965; rs212966; rs212970; rs2354002; rs490631; rs4926722; rs542281; rs550663; rs579416; rs705429; rs705432; rs850761; rs910621; rs926979; rs960721; rs960722

# Macromolecular_Interacting_Partner_31_General_References:
Not Available

# Macromolecular_Interacting_Partner_31_References:
Not Available

# Macromolecular_Interacting_Partner_32_ID:
8681

# Macromolecular_Interacting_Partner_32_Name:
Hypothetical protein DKFZp666C0510

# Macromolecular_Interacting_Partner_32_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_32_Gene_Name:
DKFZp666C0510

# Macromolecular_Interacting_Partner_32_Protein_Sequence:
>Hypothetical protein DKFZp666C0510
GVMSPDEYHSGVNNSVYTNVLVQNSLRFAAALAQDLGLPIPSQWLAVADKIKVPFDVEQN
FHPEFDGYEPGEVVKQADVVLLGYPVPFSLSPDVRRKNLEIYEAVTSPQGPAMTWSMFAV
GWMELKDAVRARGLLDRSFANMAEPFKVWTENADGSGAVNFLTGMGGFLQAVVFGCTGFR
VTRAGVTFDPVCLSGISRVSVSGIFYQGNKLNFSFSEDSVTVEVTARAGPWAPHLEAELW
PSQSRLSLLPGHKVSFPRSAGRIQMSPPKLPGSSSSEFPGRTFSDVRDPLQSPLWVTLGS
SSPTESLTVDPASE

# Macromolecular_Interacting_Partner_32_Number_of_Residues:
314

# Macromolecular_Interacting_Partner_32_Molecular_Weight:
34036

# Macromolecular_Interacting_Partner_32_Theoretical_pI:
4.86

# Macromolecular_Interacting_Partner_32_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_32_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_32_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_32_Pathway:
Not Available

# Macromolecular_Interacting_Partner_32_Reaction:
Not Available

# Macromolecular_Interacting_Partner_32_Pfam_Domain_Function:
PF03632:Glyco_hydro_65m

# Macromolecular_Interacting_Partner_32_Signals:
Not Available

# Macromolecular_Interacting_Partner_32_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_32_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_32_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_32_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_32_SwissProt_ID:
Q658X8_HUMAN (Q658X8)

# Macromolecular_Interacting_Partner_32_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_32_Genecard_id:
DKFZp666C0510

# Macromolecular_Interacting_Partner_32_Geneatlas_id:
DKFZp666C0510

# Macromolecular_Interacting_Partner_32_hgnc_id:
HGNC:26210

# Macromolecular_Interacting_Partner_32_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_32_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_32_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_32_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_32_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_32_GenBank_ID_Gene:
AL832932

# Macromolecular_Interacting_Partner_32_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_32_Locus:
Not Available

# Macromolecular_Interacting_Partner_32_SNPs:
Not Available

# Macromolecular_Interacting_Partner_32_General_References:
Not Available

# Macromolecular_Interacting_Partner_32_References:
Not Available

# Macromolecular_Interacting_Partner_33_ID:
8696

# Macromolecular_Interacting_Partner_33_Name:
Hexokinase domain containing 1

# Macromolecular_Interacting_Partner_33_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_33_Gene_Name:
HKDC1

# Macromolecular_Interacting_Partner_33_Protein_Sequence:
>Hexokinase domain containing 1
MFAVHLMAFYFSKLKEDQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAA
VKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIR
GNGTELFEYVADCLADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGV
QDTDVVSRLTKAMRRHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYME
DMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGL
YLGELVRLILLKMAKAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLG
LEPSEADCIAVQHVCTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIH
PQYPKRLHKVVRKLVPSCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLT
REQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRV
LLVKIRSGRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFT
FSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGT
MMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDI
WTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGI
FETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAI
VEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGA
ALITAVAKRLQQAQKEN

# Macromolecular_Interacting_Partner_33_Number_of_Residues:
917

# Macromolecular_Interacting_Partner_33_Molecular_Weight:
102546

# Macromolecular_Interacting_Partner_33_Theoretical_pI:
7.12

# Macromolecular_Interacting_Partner_33_GO_Classification:
>>>
 Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_33_General_Function:
Not Available

# Macromolecular_Interacting_Partner_33_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_33_Pathway:
Not Available

# Macromolecular_Interacting_Partner_33_Reaction:
Not Available

# Macromolecular_Interacting_Partner_33_Pfam_Domain_Function:
PF00349:Hexokinase_1
PF03727:Hexokinase_2

# Macromolecular_Interacting_Partner_33_Signals:
Not Available

# Macromolecular_Interacting_Partner_33_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_33_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_33_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_33_GenBank_ID_Protein:
55665502

# Macromolecular_Interacting_Partner_33_SwissProt_ID:
Q5VTC7_HUMAN (Q5VTC7)

# Macromolecular_Interacting_Partner_33_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_33_Genecard_id:
HKDC1

# Macromolecular_Interacting_Partner_33_Geneatlas_id:
HKDC1

# Macromolecular_Interacting_Partner_33_hgnc_id:
HGNC:23302

# Macromolecular_Interacting_Partner_33_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_33_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_33_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_33_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_33_Gene_Sequence:
>2754 bp
ATGTTTGCGGTCCACTTGATGGCATTTTACTTCAGCAAGCTGAAGGAGGACCAGATCAAG
AAGGTGGACAGGTTCCTGTATCACATGCGGCTCTCCGATGACACCCTTTTGGACATCATG
AGGCGGTTCCGGGCTGAGATGGAGAAGGGCCTGGCAAAGGACACCAACCCCACGGCTGCA
GTGAAGATGTTGCCCACCTTCGTCAGGGCCATTCCCGATGGTTCCGAAAATGGGGAGTTC
CTTTCCCTGGATCTCGGAGGGTCCAAGTTCCGAGTGCTGAAGGTGCAAGTCGCTGAAGAG
GGGAAGCGACACGTGCAGATGGAGAGTCAGTTCTACCCAACGCCCAATGAAATCATCCGC
GGGAACGGCACAGAGCTGTTTGAATATGTAGCTGACTGTCTGGCAGATTTCATGAAGACC
AAAGATTTAAAGCATAAGAAATTGCCCCTTGGCCTAACTTTTTCTTTCCCCTGTCGACAG
ACTAAACTGGAAGAGGGTGTCCTACTTTCGTGGACAAAAAAGTTTAAGGCACGAGGAGTT
CAGGACACGGATGTGGTGAGCCGTCTGACCAAAGCCATGAGAAGACACAAGGACATGGAC
GTGGACATCCTGGCCCTGGTCAATGACACCGTGGGGACCATGATGACCTGTGCCTATGAC
GACCCCTACTGCGAAGTTGGTGTCATCATCGGAACTGGCACCAATGCGTGTTACATGGAG
GACATGAGCAACATTGACCTGGTGGAGGGCGACGAGGGCAGGATGTGCATCAACACAGAG
TGGGGGGCCTTCGGGGACGACGGGGCCCTGGAGGACATTCGCACTGAGTTCGACAGGGAG
CTGGACCTCGGCTCTCTCAACCCAGGAAAGCAACTGTTCGAGAAGATGATCAGTGGCCTG
TACCTGGGGGAGCTTGTCAGGCTTATCTTGCTGAAGATGGCCAAGGCTGGCCTCCTGTTT
GGTGGTGAGAAATCTTCTGCTCTCCACACTAAGGGCAAGATCGAAACACGGCACGTGGCT
GCCATGGAGAAGTATAAAGAAGGCCTTGCTAATACAAGAGAGATCCTGGTGGACCTGGGT
CTGGAACCGTCTGAGGCTGACTGCATTGCCGTCCAGCATGTCTGTACCATCGTCTCCTTC
CGCTCGGCCAATCTCTGTGCAGCAGCTCTGGCGGCCATCCTGACACGCCTCCGGGAGAAC
AAGAAGGTGGAACGGCTCCGGACCACAGTGGGCATGGACGGCACCCTCTACAAGATACAC
CCTCAGTACCCAAAACGCCTGCACAAGGTGGTGAGGAAACTGGTCCCAAGCTGTGATGTC
CGCTTCCTCCTGTCAGAGAGTGGCAGCACCAAGGGGGCCGCCATGGTGACCGCGGTGGCC
TCCCGCGTGCAGGCCCAGCGGAAGCAGATCGACAGGGTGCTGGCTTTGTTCCAGCTGACC
CGAGAGCAGCTCGTGGACGTGCAGGCCAAGATGCGGGCTGAGCTGGAGTATGGGCTGAAG
AAGAAGAGCCACGGGCTGGCCACGGTCAGGATGCTGCCCACCTACGTCTGCGGGCTGCCG
GACGGCACAGAGAAAGGAAAGTTTCTCGCCCTGGATCTTGGGGGAACCAACTTCCGGGTC
CTCCTGGTGAAGATCAGAAGTGGACGGAGGTCAGTGCGAATGTACAACAAGATCTTCGCC
ATCCCCCTGGAGATCATGCAGGGCACTGGTGAGGAGCTCTTTGATCACATTGTGCAGTGC
ATCGCCGACTTCCTGGACTACATGGGCCTCAAGGGAGCCTCCCTACCTTTGGGCTTCACA
TTCTCATTTCCCTGCAGGCAGATGAGCATTGACAAGGGAACACTCATAGGGTGGACCAAA
GGTTTCAAGGCCACTGACTGTGAAGGGGAGGACGTGGTGGACATGCTCAGGGAAGCCATC
AAGAGGAGAAACGAGTTTGACCTGGACATTGTTGCAGTCGTGAATGATACAGTGGGGACC
ATGATGACCTGTGGCTATGAAGATCCTAATTGTGAGATTGGCCTGATTGCAGGAACAGGC
AGCAACATGTGCTACATGGAGGACATGAGGAACATCGAGATGGTGGAGGGGGGTGAAGGG
AAGATGTGCATCAATACAGAGTGGGGAGGATTTGGAGACAATGGCTGCATAGATGACATC
TGGACCCGATACGACACGGAGGTGGATGAGGGGTCCTTGAATCCTGGCAAGCAGAGATAC
GAGAAAATGACCAGTGGGATGTACTTGGGGGAGATTGTGCGGCAGATCCTGATCGACCTG
ACCAAGCAGGGTCTCCTCTTCCGAGGGCAGATTTCAGAGCGTCTCCGGACCAGGGGCATC
TTCGAAACCAAGTTCCTGTCCCAGATCGAAAGCGATCGGCTGGCCCTTCTCCAGGTCAGG
AGGATTCTGCAGCAGCTGGGCCTGGACAGCACGTGTGAGGACAGCATCGTGGTGAAGGAG
GTGTGCGGAGCCGTGTCCCGGCGGGCGGCCCAGCTCTGCGGTGCTGGCCTGGCCGCTATA
GTGGAAAAAAGGAGAGAAGACCAGGGGCTAGAGCACCTGAGGATCACTGTGGGTGTGGAC
GGCACCCTGTACAAGCTGCACCCTCACTTTTCTAGAATATTGCAGGAAACTGTGAAGGAA
CTAGCCCCTCGATGTGATGTGACATTCATGCTGTCAGAAGATGGCAGTGGAAAAGGGGCA
GCACTGATCACTGCTGTGGCCAAGAGGTTACAGCAGGCACAGAAGGAGAACTAG

# Macromolecular_Interacting_Partner_33_GenBank_ID_Gene:
AL596223

# Macromolecular_Interacting_Partner_33_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_33_Locus:
10q21.3

# Macromolecular_Interacting_Partner_33_SNPs:
rs906219; rs874556; rs7899445; rs10823320; rs1111335; rs5030948; rs2611; rs4746832; rs3740601; rs1472814; rs2102339; rs874557; rs7089312; rs5030946; rs10998677; rs7075720; rs5030971; rs4145930; rs7904936; rs4746825; rs5030972; rs2394529; rs953724; rs10762268; rs4746828; rs5030944; rs2279927; rs5030970; rs1983128; rs7923953; rs7918272; rs925024; rs4746823; rs10823322; rs10998673; rs4072135; rs1027793; rs10823324; rs4075240; rs10823321; rs3740600; rs11812911; rs10998657; rs7073527; rs10762271; rs10762266; rs4746826; rs12359891; rs7091503; rs11813186; rs1472815; rs4746824; rs2279930; rs4746827; rs4072136; rs10128506; rs7101003; rs9663238; rs7092167; rs2394532; rs10082520; rs7085830; rs10762269; rs7900049; rs5030941; rs9645499; rs7903151; rs7083041; rs9645501; rs12246517; rs7068302; rs10998679; rs7091301; rs4746830; rs4746822; rs12573801; rs10823325; rs12257901; rs1021964; rs10762267; rs7091496; rs10128247; rs4746831; rs7918950; rs7089277; rs5030945; rs12573334; rs7082043; rs10762270; rs7069745; rs6480393; rs9665513; rs7919018; rs7091623; rs2394531; rs5030973; rs10998656; rs16926201; rs7918356; rs1983127; rs9645500; rs12253517; rs12778771; rs10732416; rs16926175; rs1106676; rs7091505; rs12261533; rs10762265; rs9663245; rs12221182; rs17566219; rs10998665; rs2279929; rs4745978; rs3740599; rs11814510; rs10998654; rs10998658; rs10823319; rs11814154; rs7907764; rs10823326; rs10823323; rs16926179; rs12253459; rs7899214; rs7097447; rs7896577; rs10998659; rs5030913; rs12241551; rs10082355; rs4746829; rs2394530; rs17566597; rs1911225; rs12358818; rs10466014; rs11817458; rs12781552; rs10998681; rs2063046; rs4745977; rs10823318; rs17566087; rs35542013; rs35746503; rs35008643; rs10998655; rs35305687; rs36205722; rs34566173; rs9703909; rs5785902; rs35934642; rs10998670; rs11446919; rs5785906; rs41314996; rs34401681; rs35310351; rs10998663; rs12355552; rs2002012; rs10998680; rs3998838; rs36067150; rs11813849; rs12358100; rs34861627; rs7917665; rs5785903; rs3740598; rs41279652; rs10998660; rs12768756; rs35672201; rs10998669; rs10998652; rs10998653; rs33937984; rs35796674; rs9645491; rs7914955; rs5785901; rs34028207; rs35748446; rs11294938; rs7923780; rs5030942; rs12268341; rs10619082; rs34970065; rs10998664; rs10556473; rs35255281; rs11816618; rs5030947; rs2894079; rs5785905; rs7910341; rs35523344; rs35696875; rs10524347; rs10604848; rs7095933; rs12217871; rs34634483; rs10647584; rs41279650; rs36003926; rs10998675; rs33955218; rs35614872; rs10998662; rs12768466; rs1967236; rs35199395; rs35420545; rs7917667; rs10128502; rs11348828; rs10998672; rs11341726; rs35691716; rs10998674; rs10998666; rs7092458; rs10646729; rs33969502; rs5030914; rs12358099; rs34746150; rs34668088; rs5785907; rs34529083; rs5785900; rs12248244; rs11340954; rs34459941; rs34306910; rs41304621; rs35015670; rs10647585; rs12780191; rs33974062; rs10998678; rs34801386; rs12360007; rs5785904; rs3086579; rs34225892; rs10650414; rs11373074; rs9665642; rs10998667; rs11599918; rs12765400; rs10998671; rs35204234; rs10740318; rs10762263; rs10762264; rs10998643; rs10998646; rs10998647; rs10998686; rs12241136; rs1472816; rs1472818; rs2394534; rs2394538; rs34516964; rs35372667; rs5030933; rs5030937; rs5030938; rs5030939; rs5030940

# Macromolecular_Interacting_Partner_33_General_References:
Not Available

# Macromolecular_Interacting_Partner_33_References:
Not Available

# Macromolecular_Interacting_Partner_34_ID:
8713

# Macromolecular_Interacting_Partner_34_Name:
CDNA FLJ31992 fis, clone NT2RP7009149, weakly similar to GLUCOSE TRANSPORTER TYPE 2, LIVER

# Macromolecular_Interacting_Partner_34_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_34_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_34_Protein_Sequence:
>CDNA FLJ31992 fis, clone NT2RP7009149, weakly similar to 
GLUCOSE TRANSPORTER TYPE 2, LIVERMNFTHICRSHNSINQSLDESVIYGPGN
LSTNNNTLRDHFKGISSHSRSSLMPLRNDVDKRGETTSASLLNAGLSHTEYQIVTDPGDV
PAFLKWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISL
TFLTVTDLIGLPWVCFIYTIMSLASLLFVVMFIPETKGCSLEQISMELAKVNYVKNNICF
MSHHQEELVPKQPQKRKPQEQLLECNKLCGRGQSRQLSPET

# Macromolecular_Interacting_Partner_34_Number_of_Residues:
248

# Macromolecular_Interacting_Partner_34_Molecular_Weight:
27587

# Macromolecular_Interacting_Partner_34_Theoretical_pI:
7.86

# Macromolecular_Interacting_Partner_34_GO_Classification:
>>>
 Function:  carrier activity
Function:  electrochemical potential-driven transporter activity
Function:  porter activity
Function:  sugar porter activity
Function:  transporter activity
 ||
>>>
 Process:  carbohydrate transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_34_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_34_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_34_Pathway:
Not Available

# Macromolecular_Interacting_Partner_34_Reaction:
Not Available

# Macromolecular_Interacting_Partner_34_Pfam_Domain_Function:
PF00083:Sugar_tr

# Macromolecular_Interacting_Partner_34_Signals:
Not Available

# Macromolecular_Interacting_Partner_34_Transmembrane_Regions:
96-118; 128-150; 157-179

# Macromolecular_Interacting_Partner_34_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_34_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_34_GenBank_ID_Protein:
16551988

# Macromolecular_Interacting_Partner_34_SwissProt_ID:
Q96MR8_HUMAN (Q96MR8)

# Macromolecular_Interacting_Partner_34_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_34_Genecard_id:
SLC2A12

# Macromolecular_Interacting_Partner_34_Geneatlas_id:
SLC2A12

# Macromolecular_Interacting_Partner_34_hgnc_id:
HGNC:18067

# Macromolecular_Interacting_Partner_34_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_34_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_34_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_34_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_34_Gene_Sequence:
>747 bp
ATGAACTTCACCCATATCTGCAGAAGCCACAATTCTATCAACCAGTCCTTGGATGAGTCT
GTGATTTATGGACCAGGAAACCTGTCAACCAACAACAATACTCTCAGAGACCACTTCAAA
GGGATTTCTTCCCATAGCAGAAGCTCACTCATGCCCCTGAGAAATGATGTGGATAAGAGA
GGGGAGACGACCTCAGCATCCTTGCTAAATGCTGGATTAAGCCACACTGAATACCAGATA
GTCACAGACCCTGGGGACGTCCCAGCTTTTTTGAAATGGCTGTCCTTAGCCAGCTTGCTT
GTTTATGTTGCTGCTTTTTCAATTGGTCTAGGACCAATGCCCTGGCTGGTGCTCAGCGAG
ATCTTTCCTGGTGGGATCAGAGGACGAGCCATGGCTTTAACTTCTAGCATGAACTGGGGC
ATCAATCTCCTCATCTCGCTGACATTTTTGACTGTAACTGATCTTATTGGCCTGCCATGG
GTGTGCTTTATATATACAATCATGAGTCTAGCATCCCTGCTTTTTGTTGTTATGTTTATA
CCTGAGACAAAGGGATGCTCTTTGGAACAAATATCAATGGAGCTAGCAAAAGTGAACTAT
GTGAAAAACAACATTTGTTTTATGAGTCATCACCAAGAAGAATTAGTGCCAAAACAGCCT
CAAAAAAGAAAACCCCAGGAGCAGCTCTTGGAGTGTAACAAGCTGTGTGGTAGGGGCCAA
TCCAGGCAGCTTTCTCCAGAGACCTAA

# Macromolecular_Interacting_Partner_34_GenBank_ID_Gene:
AK056554

# Macromolecular_Interacting_Partner_34_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_34_Locus:
Not Available

# Macromolecular_Interacting_Partner_34_SNPs:
Not Available

# Macromolecular_Interacting_Partner_34_General_References:
Not Available

# Macromolecular_Interacting_Partner_34_References:
Not Available

# Macromolecular_Interacting_Partner_35_ID:
8780

# Macromolecular_Interacting_Partner_35_Name:
Solute carrier family 2, facilitated glucose transporter member 14

# Macromolecular_Interacting_Partner_35_Synonyms:
Glucose transporter type 14

# Macromolecular_Interacting_Partner_35_Gene_Name:
SLC2A14

# Macromolecular_Interacting_Partner_35_Protein_Sequence:
>Solute carrier family 2, facilitated glucose transporter member 14
MEFHNGGHVSGIGGFLVSLTSRMKPHTLAVTPALIFAITVATIGSFQFGYNTGVINAPET
IIKEFINKTLTDKANAPPSEVLLTNLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLI
VNLLAATGGCLMGLCKIAESVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGT
LNQLGIVIGILVAQIFGLELILGSEELWPVLLGFTILPAILQSAALPCCPESPRFLLINR
KKEENATRILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVL
QLSQQLSGINAVFYYSTGIFKDAGVQQPIYATISAGVVNTIFTLLSLFLVERAGRRTLHM
IGLGGMAFCSTLMTVSLLLKNHYNGMSFVCIGAILVFVACFEIGPGPIPWFIVAELFSQG
PRPAAMAVAGCSNWTSNFLVGLLFPSAAYYLGAYVFIIFTGFLITFLAFTFFKVPETRGR
TFEDITRAFEGQAHGADRSGKDGVMGMNSIEPAKETTTNV

# Macromolecular_Interacting_Partner_35_Number_of_Residues:
520

# Macromolecular_Interacting_Partner_35_Molecular_Weight:
56321

# Macromolecular_Interacting_Partner_35_Theoretical_pI:
7.90

# Macromolecular_Interacting_Partner_35_GO_Classification:
>>>
 Function:  carrier activity
Function:  electrochemical potential-driven transporter activity
Function:  porter activity
Function:  sugar porter activity
Function:  transporter activity
Function:  carbohydrate transporter activity
Function:  sugar transporter activity
Function:  monosaccharide transporter activity
Function:  hexose transporter activity
Function:  glucose transporter activity
 ||
>>>
 Process:  carbohydrate transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_35_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_35_Specific_Function:
Facilitative glucose transporter. May have a specific function related to spermatogenesis

# Macromolecular_Interacting_Partner_35_Pathway:
Not Available

# Macromolecular_Interacting_Partner_35_Reaction:
Not Available

# Macromolecular_Interacting_Partner_35_Pfam_Domain_Function:
PF00083:Sugar_tr

# Macromolecular_Interacting_Partner_35_Signals:
1-41

# Macromolecular_Interacting_Partner_35_Transmembrane_Regions:
30-50
89-109
118-138
149-169
178-198
208-228
294-314
329-349
359-379
393-413
424-444
452-472

# Macromolecular_Interacting_Partner_35_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_35_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_35_GenBank_ID_Protein:
19526424

# Macromolecular_Interacting_Partner_35_SwissProt_ID:
GTR14_HUMAN (Q8TDB8)

# Macromolecular_Interacting_Partner_35_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_35_Genecard_id:
SLC2A14

# Macromolecular_Interacting_Partner_35_Geneatlas_id:
SLC2A14

# Macromolecular_Interacting_Partner_35_hgnc_id:
HGNC:18301

# Macromolecular_Interacting_Partner_35_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_35_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_35_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_35_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_35_Gene_Sequence:
>1494 bp
ATGGACAACAGACAGAATGTCACCCCAGCTCTGATCTTTGCCATCACAGTTGCTACAATC
GGCTCTTTCCAGTTTGGCTACAACACTGGGGTCATCAATGCTCCTGAGACGATCATAAAG
GAATTTATCAATAAAACTTTGACGGACAAGGCAAATGCCCCTCCCTCTGAGGTGCTGCTC
ACGAATCTCTGGTCCTTGTCTGTGGCCATATTTTCCGTCGGGGGTATGATCGGCTCCTTT
TCCGTCGGACTCTTTGTTAACCGCTTTGGCAGGCGCAATTCAATGCTGATTGTCAACCTG
TTGGCTGCCACTGGTGGCTGCCTTATGGGACTGTGTAAAATAGCTGAGTCAGTTGAAATG
CTGATCCTGGGCCGCTTGGTTATTGGCCTCTTCTGCGGACTCTGCACAGGTTTTGTGCCC
ATGTACATTGGAGAGATCTCGCCTACTGCCCTGAGGGGTGCCTTTGGCACTCTCAACCAG
CTGGGCATAGTTATTGGAATTCTGGTGGCCCAGATCTTTGGTCTGGAACTCATCCTTGGG
TCTGAAGAGCTATGGCCGGTGCTATTAGGCTTTACCATCCTTCCAGCTATCCTGCAAAGT
GCAGCCCTTCCATGTTGCCCTGAAAGTCCCAGATTTTTGCTCATTAACAGAAAAAAAGAG
GAGAATGCTACGCGGATCCTCCAGCGGTTGTGGGGCACCCAGGATGTATCCCAAGACATC
CAGGAGATGAAAGATGAGAGTGCAAGGATGTCACAAGAAAAGCAAGTCACCGTGCTGGAG
CTCTTTAGAGTGTCCAGCTACCGACAGCCCATCATCATTTCCATTGTGCTCCAGCTCTCT
CAGCAGCTCTCTGGGATCAATGCTGTGTTCTATTACTCAACAGGAATCTTCAAGGATGCA
GGTGTTCAACAGCCCATCTATGCCACCATCAGCGCGGGTGTGGTTAATACTATCTTCACT
TTACTTTCTCTATTTCTGGTGGAAAGGGCAGGAAGAAGGACTCTGCATATGATAGGCCTT
GGAGGGATGGCTTTTTGTTCCACGCTCATGACTGTTTCTTTGTTATTAAAGAATCACTAT
AATGGGATGAGCTTTGTCTGTATTGGGGCTATCTTGGTCTTTGTGGCCTGTTTTGAAATT
GGACCAGGCCCCATTCCCTGGTTTATTGTGGCCGAACTCTTCAGCCAGGGCCCCCGCCCA
GCTGCGATGGCAGTGGCCGGCTGCTCCAACTGGACCTCCAACTTCCTAGTCGGATTGCTC
TTCCCCTCTGCTGCTTACTATTTAGGAGCCTACGTTTTTATTATCTTCACCGGCTTCCTC
ATTACCTTCTTGGCCTTTACCTTCTTCAAAGTCCCTGAGACCCGTGGCAGGACTTTTGAG
GATATCACACGGGCCTTTGAAGGGCAGGCACACGGTGCAGATAGATCTGGGAAGGACGGC
GTCATGGGGATGAACAGCATCGAGCCTGCTAAGGAGACCACCACCAATGTCTAA

# Macromolecular_Interacting_Partner_35_GenBank_ID_Gene:
AF481878

# Macromolecular_Interacting_Partner_35_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_35_Locus:
12p13.31

# Macromolecular_Interacting_Partner_35_SNPs:
rs10845981; rs10846018; rs10845983; rs10845982; rs3919534; rs10846078; rs4617657; rs11056210; rs10047605; rs11612319; rs4257052; rs11056204; rs4444157; rs7305822; rs4430583; rs3741856; rs12811829; rs12372273; rs12815313; rs7965592; rs11055938; rs4883444; rs1894820; rs12319367; rs2889502; rs2889501; rs4883445; rs1894821; rs10772815; rs10846072; rs10846077; rs11614408; rs4883446; rs11056079; rs7956145; rs7132415; rs4883452; rs7970550; rs11056193; rs7313616; rs4883451; rs2889545; rs6488682; rs12312185; rs7965203; rs7959391; rs7978163; rs11056048; rs10846000; rs2078173; rs7134533; rs2376905; rs7306599; rs2376906; rs11056016; rs1894829; rs2215711; rs7970664; rs11611732; rs10772799; rs7298889; rs4012951; rs16916683; rs11056192; rs12369506; rs2377062; rs7955197; rs10845990; rs7956032; rs7306351; rs7972370; rs7134840; rs1056992; rs2889504; rs7300785; rs10772774; rs2376904; rs12312135; rs7980954; rs10772775; rs11055977; rs7313138; rs9804752; rs6488683; rs7136630; rs10772787; rs10772779; rs10845999; rs4883447; rs4564403; rs7308065; rs11833776; rs4489822; rs11055981; rs10846007; rs7306805; rs4883448; rs10466775; rs6488694; rs4447244; rs2215712; rs2889505; rs7966554; rs7961037; rs10846010; rs10734881; rs11616119; rs12812273; rs7135876; rs6488707; rs10845997; rs4883449; rs10846008; rs11610337; rs11056095; rs4402376; rs10744063; rs10846063; rs10846057; rs7974873; rs7961726; rs12372301; rs12310967; rs2376903; rs6488690; rs4883450; rs17728008; rs7965853; rs17727996; rs7959365; rs10744068; rs10846011; rs10846009; rs10845986; rs2159898; rs7976689; rs7959746; rs7301559; rs1894824; rs1894822; rs4883443; rs7301531; rs11055935; rs11837392; rs7298243; rs12582018; rs12297867; rs12321127; rs34687462; rs11837567; rs11056231; rs7965290; rs11615520; rs7971169; rs2376902; rs7300869; rs2215713; rs11055940; rs34596682; rs34320554; rs34707191; rs12301343; rs35684828; rs35685922; rs34420890; rs11056205; rs34551601; rs4396354; rs11612250; rs11055941; rs11613773; rs2889503; rs35414391; rs11056035; rs36233250; rs5025503; rs35677028; rs35257564; rs9804906; rs34140810; rs7967548; rs28645515; rs34332998; rs11055945; rs34419496; rs12311588; rs35632480; rs36068117; rs12227645; rs35104251; rs11055950; rs34923333; rs35940282; rs34587080; rs28621393; rs34900677; rs9804968; rs36014534; rs35453883; rs34224977; rs28417841; rs11613889; rs34854705; rs35386927; rs34465038; rs7979727; rs7137578; rs12827102; rs34368487; rs28489574; rs28537205; rs12824948; rs28750840; rs11833513; rs36095965; rs7976683; rs12818325; rs34816267; rs11055978; rs35048170; rs35067057; rs34695925; rs35162971; rs35612191; rs7964387; rs5025502; rs35933519; rs28735741; rs7964399; rs5796294; rs10744066; rs7956469; rs9738166; rs6488691; rs12368117; rs4606545; rs12299734; rs3040791; rs35242097; rs35067640; rs35890481; rs11056105; rs28540675; rs34023090; rs12320590; rs35417445; rs4012952; rs35514872; rs33912738; rs5015582; rs7303040; rs28654145; rs2377082; rs11056033; rs12821197; rs4883060; rs7960339; rs28477402; rs34902187; rs34697312; rs7977066; rs35671328; rs28408758; rs35553530; rs34231685; rs11055994; rs35933580; rs7306216; rs35974170; rs11838167; rs12310974; rs35156149; rs4492886; rs11056049; rs35629381; rs10846003; rs7976694; rs35899117; rs7306531; rs35142190; rs12318277; rs35110659; rs11055985; rs5015583; rs10466776; rs28530751; rs12302198; rs7980994; rs3040823; rs35637766; rs12307656; rs7956462; rs35913834; rs3040795; rs35431221; rs28435073; rs4883061; rs34786055; rs12314201; rs5015584; rs12315915; rs34761020; rs34925389; rs35889401; rs28666368; rs35416196; rs4408376; rs36009731; rs11056043; rs34895613; rs33980644; rs34817500; rs34653071; rs34122127; rs6488684; rs2110092; rs12372272; rs12231173; rs34192898; rs35210860; rs12318604; rs12310978; rs5796296; rs11055975; rs3953990; rs36141788; rs35128188; rs4012950; rs34091612; rs7980787; rs36124279; rs35137540; rs11056149; rs11612844; rs12369932; rs35582503; rs12228543; rs34899970; rs7306364; rs7137803; rs1894828; rs3040822; rs35747678; rs34084275; rs34663783; rs11055931; rs35798487; rs7132811; rs35540081; rs10734883; rs10772758; rs10772766; rs10845939; rs10845940; rs10845951; rs10846083; rs10846086; rs10846098; rs10846102; rs11055873; rs11055874; rs11055897; rs11055899; rs11055905; rs12372284; rs2377091; rs2377092; rs2377093; rs35715795; rs3923481; rs3923482; rs4283058; rs4562898; rs4883454; rs7135073; rs7300773; rs7303617; rs7312589; rs7313244; rs7486304; rs7969162

# Macromolecular_Interacting_Partner_35_General_References:
12504846

# Macromolecular_Interacting_Partner_35_References:
Not Available

# Macromolecular_Interacting_Partner_36_ID:
8786

# Macromolecular_Interacting_Partner_36_Name:
Aflatoxin B1 aldehyde reductase member 2

# Macromolecular_Interacting_Partner_36_Synonyms:
AFB1-AR 1; Aldoketoreductase 7

# Macromolecular_Interacting_Partner_36_Gene_Name:
AKR7A2

# Macromolecular_Interacting_Partner_36_Protein_Sequence:
>Aflatoxin B1 aldehyde reductase member 2
MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAV
RAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVR
SQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAE
ICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYE
DKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMY
HHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR

# Macromolecular_Interacting_Partner_36_Number_of_Residues:
359

# Macromolecular_Interacting_Partner_36_Molecular_Weight:
39589

# Macromolecular_Interacting_Partner_36_Theoretical_pI:
7.18

# Macromolecular_Interacting_Partner_36_GO_Classification:
>>>
 Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_36_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_36_Specific_Function:
Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen

# Macromolecular_Interacting_Partner_36_Pathway:
Not Available

# Macromolecular_Interacting_Partner_36_Reaction:
Not Available

# Macromolecular_Interacting_Partner_36_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Macromolecular_Interacting_Partner_36_Signals:
Not Available

# Macromolecular_Interacting_Partner_36_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_36_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_36_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_36_GenBank_ID_Protein:
56417840

# Macromolecular_Interacting_Partner_36_SwissProt_ID:
ARK72_HUMAN (O43488)

# Macromolecular_Interacting_Partner_36_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_36_Genecard_id:
AKR7A2

# Macromolecular_Interacting_Partner_36_Geneatlas_id:
AKR7A2

# Macromolecular_Interacting_Partner_36_hgnc_id:
HGNC:389

# Macromolecular_Interacting_Partner_36_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_36_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_36_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_36_Subcellular_Location:
Golgi apparatus

# Macromolecular_Interacting_Partner_36_Gene_Sequence:
>993 bp
ATGTCCCGGCCACCGCCACCGCGGGTCGCCTCGGTGCTGGGCACCATGGAGATGGGGCGC
CGCATGGACGCGCCCGCCAGCGCCGCGGCCGTGCGCGCCTTTCTGGAGCGCGGCCACACC
GAACTGGACACGGCCTTCATGTACAGCGACGGCCAGTCCGAGACCATCCTGGGCGGCCTG
GGGCTCGGGCTGGGCGGTGGCGACTGCAGAGTGAAAATTGCCACCAAGGCCAACCCTTGG
GATGGAAAATCACTAAAGCCTGACAGTGTCCGGTCCCAGCTGGAGACGTCATTGAAGAGG
CTGCAGTGTCCCCAAGTGGACCTCTTCTACCTACACGCACCTGACCACGGCACCCCGGTG
GAAGAGACGCTGCATGCCTGCCAGCGGCTGCACCAGGAGGGCAAGTTCGTGGAGCTTGGC
CTCTCCAACTATGCTAGCTGGGAAGTGGCCGAGATCTGTACCCTCTGCAAGAGCAATGGC
TGGATCCTGCCCACTGTGTACCAGGGCATGTACAACGCCACCACCCGGCAGGTGGAAACG
GAGCTCTTCCCCTGCCTCAGGCACTTTGGACTGAGGTTCTATGCCTACAACCCTCTGGCT
GGGGGCCTGCTGACTGGCAAGTACAAGTATGAGGACAAGGACGGGAAACAGCCTGTGGGC
CGCTTCTTTGGGAATAGCTGGGCTGAGACCTACAGGAATCGCTTCTGGAAGGAGCACCAC
TTCGAGGCCATTGCGTTGGTGGAGAAGGCCCTGCAGGCCGCATATGGCGCCAGCGCCCCC
AGTGTGACCTCGGCTGCCCTCCGGTGGATGTACCACCACTCACAGCTGCAGGGTGCCCAC
GGGGACGCGGTCATCCTGGGCATGTCCAGCCTGGAGCAGCTGGAGCAGAACTTGGCAGCA
ACAGAGGAAGGGCCCCTGGAGCCGGCTGTCGTGGATGCCTTTAATCAAGCCTGGCATTTG
GTTGCTCACGAATGTCCCAACTACTTCCGCTAG

# Macromolecular_Interacting_Partner_36_GenBank_ID_Gene:
AL035413

# Macromolecular_Interacting_Partner_36_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_36_Locus:
1p35.1-p36.23

# Macromolecular_Interacting_Partner_36_SNPs:
rs859208; rs859210; rs1043657; rs1535037; rs7525784; rs11808495; rs3762394; rs11588059; rs3835240; rs3828102; rs3790778; rs3762393; rs10917355; rs11553813; rs11584828; rs2231203; rs2231206; rs6670759; rs2231200; rs11550269; rs2231202; rs2231207; rs35963759; rs2231201; rs2231196; rs1543366; rs2473810; rs859212; rs2231197; rs7549207; rs859209; rs859211; rs2231205; rs2231204; rs2231199; rs2473811; rs2473809; rs10681799; rs34982182; rs1018429; rs12132200; rs12133034; rs12138571; rs12140547; rs12146076; rs12407355; rs12407385; rs2064378; rs2073097; rs2073098; rs2073099; rs2073101; rs2227295; rs2231191; rs2231192; rs2231193; rs2231194; rs2231195; rs2473807; rs2473808; rs33997183; rs3762389; rs3762391; rs4911983; rs4912066; rs4912069; rs7528174; rs859213; rs859214; rs859215; rs859216; rs859217; rs859218

# Macromolecular_Interacting_Partner_36_General_References:
9576847; 9823300; 12071861

# Macromolecular_Interacting_Partner_36_References:
Not Available

# Macromolecular_Interacting_Partner_37_ID:
8805

# Macromolecular_Interacting_Partner_37_Name:
Hypothetical protein DKFZp781L0455

# Macromolecular_Interacting_Partner_37_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_37_Gene_Name:
DKFZp781L0455

# Macromolecular_Interacting_Partner_37_Protein_Sequence:
>Hypothetical protein DKFZp781L0455
MDFLHRNGVLIIQHLQKDYRAYYTFLNFMSNVGDPRNIFFIYFPLCFQFNQTVGTKMIWV
AVIGDWLNLIFKWKSIWPCNGRILCLVCHGNRCPEPHCLWDG

# Macromolecular_Interacting_Partner_37_Number_of_Residues:
102

# Macromolecular_Interacting_Partner_37_Molecular_Weight:
12160

# Macromolecular_Interacting_Partner_37_Theoretical_pI:
8.38

# Macromolecular_Interacting_Partner_37_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_37_General_Function:
Not Available

# Macromolecular_Interacting_Partner_37_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_37_Pathway:
Not Available

# Macromolecular_Interacting_Partner_37_Reaction:
Not Available

# Macromolecular_Interacting_Partner_37_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_37_Signals:
Not Available

# Macromolecular_Interacting_Partner_37_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_37_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_37_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_37_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_37_SwissProt_ID:
Q6AHZ0_HUMAN (Q6AHZ0)

# Macromolecular_Interacting_Partner_37_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_37_Genecard_id:
DKFZp781L0455

# Macromolecular_Interacting_Partner_37_Geneatlas_id:
DKFZp781L0455

# Macromolecular_Interacting_Partner_37_hgnc_id:
HGNC:28906

# Macromolecular_Interacting_Partner_37_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_37_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_37_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_37_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_37_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_37_GenBank_ID_Gene:
CR627438

# Macromolecular_Interacting_Partner_37_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_37_Locus:
Not Available

# Macromolecular_Interacting_Partner_37_SNPs:
Not Available

# Macromolecular_Interacting_Partner_37_General_References:
Not Available

# Macromolecular_Interacting_Partner_37_References:
Not Available

# Macromolecular_Interacting_Partner_38_ID:
8838

# Macromolecular_Interacting_Partner_38_Name:
Solute carrier family 2, facilitated glucose transporter member 9

# Macromolecular_Interacting_Partner_38_Synonyms:
Glucose transporter type 9

# Macromolecular_Interacting_Partner_38_Gene_Name:
SLC2A9

# Macromolecular_Interacting_Partner_38_Protein_Sequence:
>Solute carrier family 2, facilitated glucose transporter member 9
MARKQNRNSKELGLVPLTDDTSHARPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVAS
LAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIG
GLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGV
ALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVV
PAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIR
LVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPLAKIPYVTLST
GGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLTLQDHAPWVPYLSIVGIL
AIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYC
FLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRP


# Macromolecular_Interacting_Partner_38_Number_of_Residues:
540

# Macromolecular_Interacting_Partner_38_Molecular_Weight:
58818

# Macromolecular_Interacting_Partner_38_Theoretical_pI:
9.24

# Macromolecular_Interacting_Partner_38_GO_Classification:
>>>
 Function:  carrier activity
Function:  electrochemical potential-driven transporter activity
Function:  porter activity
Function:  sugar porter activity
Function:  transporter activity
 ||
>>>
 Process:  carbohydrate transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_38_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_38_Specific_Function:
Facilitative glucose transporter

# Macromolecular_Interacting_Partner_38_Pathway:
Not Available

# Macromolecular_Interacting_Partner_38_Reaction:
Not Available

# Macromolecular_Interacting_Partner_38_Pfam_Domain_Function:
PF00083:Sugar_tr

# Macromolecular_Interacting_Partner_38_Signals:
Not Available

# Macromolecular_Interacting_Partner_38_Transmembrane_Regions:
52-72
108-128
141-161
172-192
201-221
232-252
317-337
355-375
382-402
416-436
452-472
479-499

# Macromolecular_Interacting_Partner_38_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_38_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_38_GenBank_ID_Protein:
9230651

# Macromolecular_Interacting_Partner_38_SwissProt_ID:
GTR9_HUMAN (Q9NRM0)

# Macromolecular_Interacting_Partner_38_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_38_Genecard_id:
SLC2A9

# Macromolecular_Interacting_Partner_38_Geneatlas_id:
SLC2A9

# Macromolecular_Interacting_Partner_38_hgnc_id:
HGNC:13446

# Macromolecular_Interacting_Partner_38_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_38_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_38_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_38_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_38_Gene_Sequence:
>1623 bp
ATGGCAAGGAAACAAAATAGGAATTCCAAGGAACTGGGCCTAGTTCCCCTCACAGATGAC
ACCAGCCACGCCAGGCCTCCAGGGCCAGGGAGGGCACTGCTGGAGTGTGACCACCTGAGG
AGTGGGGTGCCAGGTGGAAGGAGAAGAAAGGACTGGTCCTGCTCGCTCCTCGTGGCCTCC
CTCGCGGGCGCCTTCGGCTCCTCCTTCCTCTACGGCTACAACCTGTCGGTGGTGAATGCC
CCCACCCCGTACATCAAGGCCTTTTACAATGAGTCATGGGAAAGAAGGCATGGACGTCCA
ATAGACCCAGACACTCTGACTCTGCTCTGGTCTGTGACTGTGTCCATATTCGCCATCGGT
GGACTTGTGGGGACATTAATTGTGAAGATGATTGGAAAGGTTCTTGGGAGGAAGCACACT
TTGCTGGCCAATAATGGGTTTGCAATTTCTGCTGCATTGCTGATGGCCTGCTCGCTCCAG
GCAGGAGCCTTTGAAATGCTCATCGTGGGACGCTTCATCATGGGCATAGATGGAGGCGTC
GCCCTCAGTGTGCTCCCCATGTACCTCAGTGAGATCTCACCCAAGGAGATCCGTGGCTCT
CTGGGGCAGGTGACTGCCATCTTTATCTGCATTGGCGTGTTCACTGGGCAGCTTCTGGGC
CTGCCCGAGCTGCTGGGAAAGGAGAGTACCTGGCCATACCTGTTTGGAGTGATTGTGGTC
CCTGCCGTTGTCCAGCTGCTGAGCCTTCCCTTTCTCCCGGACAGCCCACGCTACCTGCTC
TTGGAGAAGCACAACGAGGCAAGAGCTGTGAAAGCCTTCCAAACGTTCTTGGGTAAAGCA
GACGTTTCCCAAGAGGTAGAGGAGGTCCTGGCTGAGAGCCGCGTGCAGAGGAGCATCCGC
CTGGTGTCCGTGCTGGAGCTGCTGAGAGCTCCCTACGTCCGCTGGCAGGTGGTCACCGTG
ATTGTCACCATGGCCTGCTACCAGCTCTGTGGCCTCAATGCAATTTGGTTCTATACCAAC
AGCATCTTTGGAAAAGCTGGGATCCCTCTGGCAAAGATCCCATACGTCACCTTGAGTACA
GGGGGCATCGAGACTTTGGCTGCCGTCTTCTCTGGTTTGGTCATTGAGCACCTGGGACGG
AGACCCCTCCTCATTGGTGGCTTTGGGCTCATGGGCCTCTTCTTTGGGACCCTCACCATC
ACGCTGACCCTGCAGGACCACGCCCCCTGGGTCCCCTACCTGAGTATCGTGGGCATTCTG
GCCATCATCGCCTCTTTCTGCAGTGGGCCAGGTGGCATCCCGTTCATCTTGACTGGTGAG
TTCTTCCAGCAATCTCAGCGGCCGGCTGCCTTCATCATTGCAGGCACCGTCAACTGGCTC
TCCAACTTTGCTGTTGGGCTCCTCTTCCCATTCATTCAGAAAAGTCTGGACACCTACTGT
TTCCTAGTCTTTGCTACAATTTGTATCACAGGTGCTATCTACCTGTATTTTGTGCTGCCT
GAGACCAAAAACAGAACCTATGCAGAAATCAGCCAGGCATTTTCCAAAAGGAACAAAGCA
TACCCACCAGAAGAGAAAATCGACTCAGCTGTCACTGATGGTAAGATAAATGGAAGGCCT
TAA

# Macromolecular_Interacting_Partner_38_GenBank_ID_Gene:
AF210317

# Macromolecular_Interacting_Partner_38_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_38_Locus:
4p16-p15.3

# Macromolecular_Interacting_Partner_38_SNPs:
rs6820230; rs2280205; rs16890979; rs3733591; rs2276961; rs13113918; rs3733589; rs10939650; rs13125646; rs10006397; rs6846692; rs13115776; rs10939663; rs6449237; rs6856396; rs13146686; rs12506122; rs12642537; rs16892420; rs10939665; rs11727199; rs10516196; rs10012779; rs13139055; rs16892449; rs12506455; rs6449238; rs6826764; rs16892493; rs16892419; rs3822250; rs9291645; rs4485819; rs16892475; rs11731110; rs11722930; rs12508991; rs12506932; rs7697004; rs7669699; rs16892474; rs11734786; rs6820616; rs10029311; rs10002608; rs3733584; rs6827401; rs16892483; rs7697416; rs12500810; rs6856430; rs13135351; rs3733585; rs2176644; rs939134; rs1014290; rs874432; rs938554; rs1914874; rs1401439; rs938564; rs1519098; rs1320054; rs734553; rs4476596; rs6849273; rs10805346; rs6814664; rs12498150; rs6449172; rs4428284; rs7674711; rs1079128; rs4473653; rs10939552; rs10012880; rs6812007; rs4697903; rs6449051; rs4292328; rs4697910; rs950310; rs6849729; rs6853437; rs6449155; rs7376948; rs4697895; rs4314284; rs9291640; rs9684729; rs1464259; rs6824636; rs4382035; rs1464258; rs2292916; rs7665666; rs6831796; rs4519796; rs4697695; rs4235348; rs12498956; rs6817564; rs1568318; rs6836200; rs6850143; rs2280204; rs6838850; rs6812563; rs6449173; rs10002519; rs6449178; rs6834893; rs7660895; rs998675; rs6839490; rs10016075; rs3733587; rs2867394; rs6449159; rs4336225; rs11735831; rs7698858; rs11737821; rs4376135; rs4455410; rs11935405; rs6843873; rs6852425; rs1976792; rs11737685; rs10008035; rs7435196; rs939135; rs6449174; rs7439210; rs737267; rs6449090; rs9993652; rs6449026; rs6818572; rs7683831; rs13145758; rs13127090; rs4560411; rs6449050; rs6449097; rs10022499; rs2280203; rs6449183; rs4697692; rs6449043; rs11942223; rs6849736; rs938563; rs4511996; rs13328050; rs4697700; rs6849717; rs7694997; rs4235346; rs6836706; rs9994266; rs3775948; rs11732681; rs883041; rs3733588; rs10025644; rs4339211; rs7378340; rs7680554; rs10017674; rs7375587; rs4389579; rs3796839; rs4621431; rs6449179; rs6449045; rs998676; rs9998811; rs6826806; rs6815001; rs4459990; rs10025968; rs6850684; rs938552; rs1114199; rs6449202; rs12498742; rs7683283; rs10805343; rs4697693; rs7680126; rs6844316; rs4447861; rs6449052; rs6449175; rs11931553; rs6449201; rs7663097; rs6449049; rs6840802; rs881971; rs938562; rs4447863; rs4697913; rs7658170; rs10939561; rs6856127; rs6449100; rs6449171; rs7676733; rs4311316; rs11723439; rs4639072; rs6449176; rs6814556; rs9993410; rs10023068; rs7442295; rs2018643; rs950309; rs4475146; rs7375599; rs11934363; rs9992406; rs1401442; rs10939600; rs4697908; rs7672947; rs4697694; rs4529048; rs6449157; rs4385059; rs4312757; rs7675964; rs882223; rs13125209; rs4515163; rs3733586; rs6449166; rs12647249; rs938558; rs1878278; rs10030570; rs6848689; rs3796842; rs6838021; rs13140718; rs1107710; rs11722229; rs6840999; rs6839302; rs6449046; rs6828040; rs13148571; rs7376960; rs6838891; rs6449177; rs4292332; rs6855911; rs16891234; rs10017945; rs7700047; rs7378305; rs7669444; rs7677710; rs2240724; rs9990770; rs4543113; rs4235344; rs4481233; rs6845554; rs3796837; rs10009657; rs6823129; rs10003001; rs9991278; rs11941148; rs6828184; rs3733590; rs16889842; rs4518244; rs4292333; rs10032756; rs13122112; rs16891489; rs2240723; rs6837273; rs12646380; rs3775949; rs3756236; rs17246501; rs6449218; rs7666545; rs11721988; rs6837224; rs3796834; rs3796841; rs11732054; rs2001412; rs9998739; rs6836878; rs6827754; rs884573; rs1401440; rs4467563; rs4467564; rs7437120; rs13141635; rs7657096; rs7681699; rs6847858; rs17245436; rs11933731; rs7674723; rs17185835; rs11723970; rs6847871; rs6832439; rs938553; rs4697698; rs4622999; rs10010582; rs5028843; rs16891285; rs3796838; rs12499857; rs6449139; rs4697896; rs12644047; rs7670751; rs11941346; rs13129697; rs12649245; rs6823361; rs7679724; rs16891923; rs6852441; rs4235347; rs4306953; rs13131257; rs6844787; rs6449165; rs3796829; rs10516195; rs12507606; rs6856012; rs4407505; rs2240722; rs7678012; rs3756234; rs6449128; rs4697905; rs16890590; rs6819833; rs4408959; rs11727666; rs6449089; rs12647883; rs6449154; rs10027276; rs11933838; rs13142238; rs10001964; rs11736479; rs16889509; rs3796830; rs3796831; rs10516194; rs882222; rs6414766; rs12505312; rs10018204; rs7688167; rs4697909; rs7375642; rs2012177; rs4697914; rs6818643; rs10939608; rs6449158; rs6449213; rs10939599; rs6858614; rs6823324; rs3775942; rs6449027; rs13119059; rs11934050; rs7687971; rs4697900; rs10939567; rs6449167; rs6822988; rs16891926; rs6847887; rs2276962; rs17187075; rs13111638; rs2139243; rs4697701; rs16889496; rs10939605; rs4575993; rs938555; rs3775940; rs4502681; rs1122141; rs6449140; rs10031303; rs13101772; rs1007872; rs6833878; rs13107656; rs6857001; rs3775950; rs1122142; rs6449044; rs7434391; rs10805342; rs11940661; rs6831580; rs4235345; rs7375643; rs13115121; rs7696971; rs7377625; rs6837336; rs11722228; rs1071988; rs16889691; rs11723382; rs7694136; rs6825187; rs11723591; rs7686538; rs3796832; rs12644471; rs4580649; rs1106058; rs6811809; rs11726102; rs10000983; rs6449028; rs2240720; rs4547795; rs12507050; rs12642114; rs17185870; rs7696536; rs9996799; rs4697899; rs10018663; rs16890728; rs13118801; rs4591605; rs16892124; rs11731759; rs884572; rs4144; rs3775943; rs10000582; rs13136962; rs6823036; rs13103690; rs16889260; rs10461113; rs13129080; rs10939558; rs4507358; rs11728377; rs9994937; rs16890905; rs13105954; rs4467565; rs11943372; rs3775946; rs7688629; rs10939638; rs13113006; rs4575994; rs13128385; rs6449156; rs6817961; rs11930388; rs3834235; rs9684568; rs4583762; rs6823758; rs11942592; rs7663079; rs6449217; rs6850631; rs7689097; rs4276278; rs4447862; rs1122966; rs11930077; rs1048252; rs16889264; rs3796833; rs13114090; rs7669607; rs16891964; rs6827785; rs9990954; rs12642431; rs3756233; rs4466042; rs16889270; rs2276964; rs4697696; rs3215275; rs12650373; rs13125476; rs7696895; rs6832456; rs12647117; rs7669296; rs13142273; rs13103497; rs7658183; rs3775947; rs11726476; rs4697902; rs12506364; rs11936395; rs4697904; rs7678287; rs6847291; rs16889522; rs13139970; rs7696983; rs2102872; rs13103429; rs4318650; rs4697691; rs4333184; rs13115193; rs2276965; rs3756237; rs6847019; rs11729337; rs9291641; rs3796840; rs10022660; rs10004947; rs7376505; rs938561; rs35201034; rs4318649; rs16891971; rs6844329; rs6449144; rs11736410; rs6839218; rs7695555; rs11939701; rs13116446; rs1980219; rs11726221; rs12641340; rs7662439; rs10939636; rs13129868; rs4697697; rs10033612; rs2139242; rs12500805; rs6832792; rs16892069; rs6816053; rs10018666; rs10939654; rs13103879; rs11723024; rs13106922; rs751092; rs12505366; rs4697901; rs16891020; rs16891746; rs9992815; rs1401441; rs4364264; rs6857478; rs16868271; rs4639073; rs7376154; rs6857693; rs6840000; rs2090606; rs7696092; rs16889932; rs2240721; rs13108825; rs7661339; rs10939614; rs11938613; rs16889519; rs7377578; rs3775939; rs12644592; rs13122026; rs3756231; rs2280202; rs11724510; rs13125029; rs3756238; rs7690760; rs6810736; rs3775944; rs12507330; rs13435427; rs11947634; rs16868246; rs13102218; rs17246745; rs11734219; rs4292327; rs13101688; rs3796835; rs10939637; rs13144899; rs7684245; rs4697699; rs10939602; rs1106059; rs6823877; rs12643688; rs10939655; rs7677964; rs938559; rs4312756; rs10003673; rs13151331; rs9684002; rs13137069; rs13126729; rs6449137; rs7684306; rs10939656; rs12503064; rs13132625; rs7663032; rs6844216; rs10007726; rs4697898; rs11946054; rs9996229; rs17247314; rs13133766; rs12509955; rs1850741; rs7683856; rs6449110; rs4505821; rs6834978; rs10033286; rs6829755; rs12510791; rs7699609; rs6849962; rs7669698; rs4613568; rs2276963; rs3775941; rs17245723; rs11734893; rs7682751; rs11938866; rs7376155; rs11932393; rs4481234; rs13106991; rs7657340; rs2292917; rs3796836; rs10011206; rs11930098; rs7349721; rs6822889; rs7679916; rs13137343; rs4621429; rs6850166; rs10516197; rs7685958; rs938557; rs4697893; rs13101785; rs35560971; rs35389911; rs35669982; rs35476936; rs7683792; rs35283221; rs13145442; rs4525975; rs11729463; rs35451018; rs35446155; rs35305635; rs4635816; rs34995175; rs34325511; rs33929543; rs34064943; rs4642250; rs11727083; rs13149985; rs7669090; rs35698968; rs11396953; rs13148371; rs33987363; rs35249656; rs34709913; rs13141233; rs33993848; rs36084205; rs34064545; rs34150058; rs6838317; rs13141248; rs11731339; rs13145174; rs34052379; rs33911697; rs10712892; rs34450770; rs7680896; rs884574; rs36000153; rs13121355; rs3060765; rs36211198; rs10009838; rs6811909; rs34876394; rs11453559; rs36049330; rs34495474; rs35095818; rs16891239; rs13124563; rs11355082; rs6148297; rs4280729; rs4410528; rs33988387; rs11326079; rs35270015; rs4640670; rs938550; rs11732055; rs35561020; rs6825480; rs34644460; rs33959222; rs28558552; rs34082587; rs4343726; rs35734541; rs35380388; rs35899770; rs35512765; rs3756232; rs35873496; rs28489733; rs35994328; rs7666787; rs36105149; rs33935471; rs10540197; rs6835326; rs34788376; rs36216378; rs34904078; rs28755795; rs4305511; rs6843447; rs938560; rs35866697; rs36045597; rs35173995; rs5856027; rs10530926; rs34263170; rs10591573; rs11938161; rs35303241; rs34376048; rs34108469; rs28480661; rs7663044; rs3834811; rs35361506; rs33937422; rs4588456; rs35642544; rs34838359; rs34063341; rs28462017; rs2030286; rs28837683; rs10663865; rs34008312; rs4697907; rs5856025; rs35184355; rs34377168; rs13145683; rs35824350; rs34521081; rs35188468; rs4295260; rs28610447; rs28607048; rs33998464; rs7698058; rs883042; rs34823069; rs34560968; rs34237127; rs4697906; rs3060766; rs13121211; rs33921469; rs35668897; rs34198619; rs33958336; rs13435674; rs33942679; rs35605137; rs28538404; rs11438839; rs35419761; rs34012301; rs13117275; rs13107466; rs35495195; rs6449196; rs28868569; rs13152172; rs10565284; rs35271694; rs6838986; rs34401893; rs33946234; rs28715627; rs35756148; rs34365181; rs34658962; rs1114200; rs28414776; rs35000655; rs35409670; rs13122290; rs7692145; rs5856022; rs33954922; rs13151113; rs35099040; rs13140813; rs34542233; rs4546242; rs28718559; rs10544662; rs35334750; rs13145554; rs13113546; rs13128821; rs35726737; rs11301291; rs28429694; rs5856028; rs13145654; rs11352991; rs34945903; rs13112015; rs12643735; rs28571073; rs6815895; rs35752363; rs6840984; rs13128214; rs28392795; rs10553268; rs9998156; rs28496610; rs28656237; rs13115469; rs11338281; rs35817865; rs34405928; rs34540530; rs35762143; rs36042284; rs4697912; rs34567300; rs16890933; rs35134320; rs11436170; rs35222741; rs35908990; rs34245354; rs34014852; rs28677023; rs13151822; rs35491342; rs6449053; rs3060767; rs13132524; rs33949167; rs11381848; rs34543010; rs34426626; rs10005326; rs11944114; rs34200715; rs13145108; rs34809146; rs34597329; rs11931794; rs34545348; rs34067115; rs34759910; rs11460716; rs13141527; rs33969288; rs34839464; rs34059606; rs13114702; rs5856023; rs35837635; rs35596118; rs6841908; rs28643326; rs34572728; rs13113730; rs35922993; rs35385770; rs34162643; rs6855445; rs34018959; rs10006833; rs41268377; rs6820866; rs35108442; rs35076540; rs9291642; rs35954357; rs35699404; rs36098757; rs6845125; rs9683763; rs28395504; rs13148184; rs35952218; rs10049856; rs10578751; rs35767306; rs35955619; rs35614040; rs4295261; rs36216377; rs35141218; rs6818293; rs11341140; rs35993815; rs4345181; rs34103547; rs28699682; rs13101683; rs34707376; rs4340792; rs13114106; rs28579290; rs35279247; rs13116337; rs28560387; rs34543007; rs12640358; rs35139094; rs34997016; rs3960679; rs13141246; rs28591077; rs6823549; rs28449404; rs34297373; rs4535335; rs34043940; rs35135869; rs34269125; rs17242364; rs11274332; rs28757356; rs34501273; rs35574155; rs34437283; rs10701920; rs7695113; rs35933336; rs5014939; rs35165985; rs28675082; rs34058781; rs35653636; rs11937310; rs34198277; rs13112998; rs10939620; rs2996522; rs35438220; rs4627861; rs35371429; rs4264828; rs10537327; rs35643452; rs35950306; rs28592748; rs10617389; rs35851090; rs34088729; rs6856989; rs34913390; rs12108499; rs34430411; rs938551; rs28735365; rs35342884; rs3832312; rs28602527; rs28613263; rs11338280; rs34588837; rs35489680; rs11420026; rs28504140; rs28606518; rs33947690; rs13132516; rs28624182; rs28513781; rs3060764; rs11448227; rs10653847; rs11490074; rs6853922; rs16890938; rs13141026; rs10640118; rs34188056; rs35034550; rs28546304; rs10555360; rs35933067; rs4385058; rs11455833; rs35999832; rs28505891; rs7698349; rs34249207; rs6856280; rs13148476; rs34752819; rs3775945; rs11940038; rs41268375; rs4495037; rs34407859; rs16891038; rs11932607; rs34536860; rs11726620; rs35661791; rs34748970; rs746082; rs4697897; rs35344864; rs13101562; rs36058283; rs34213329; rs35030074; rs34124969; rs13106450; rs3834812; rs5856024; rs34380266; rs11319474; rs35110076; rs10033424; rs3756235; rs35382051; rs34421806; rs34814263; rs6843466; rs3762935; rs9994216; rs35629527; rs33955461; rs36036984; rs16892534; rs13137074; rs34535019; rs35944600; rs35759883; rs5856021; rs4697894; rs35928671; rs10020053; rs10939669; rs1107912; rs11726423; rs12499734; rs13110307; rs13129453; rs13137795; rs13141706; rs1401437; rs1519092; rs1519093; rs1519099; rs1878276; rs1996335; rs2066; rs2867393; rs3762933; rs4391034; rs4529049; rs4637402; rs4697891; rs4697892; rs5014938; rs6449009; rs6855095; rs733175; rs7657116; rs7658814; rs7687896; rs7695879; rs939132

# Macromolecular_Interacting_Partner_38_General_References:
10860667

# Macromolecular_Interacting_Partner_38_References:
Not Available

# Macromolecular_Interacting_Partner_39_ID:
8849

# Macromolecular_Interacting_Partner_39_Name:
Sodium/glucose cotransporter 2

# Macromolecular_Interacting_Partner_39_Synonyms:
Na(+/glucose cotransporter 2; Low affinity sodium-glucose cotransporter

# Macromolecular_Interacting_Partner_39_Gene_Name:
SLC5A2

# Macromolecular_Interacting_Partner_39_Protein_Sequence:
>Sodium/glucose cotransporter 2
MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA

# Macromolecular_Interacting_Partner_39_Number_of_Residues:
672

# Macromolecular_Interacting_Partner_39_Molecular_Weight:
72898

# Macromolecular_Interacting_Partner_39_Theoretical_pI:
7.51

# Macromolecular_Interacting_Partner_39_GO_Classification:
>>>
 Function:  transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_39_General_Function:
Not Available

# Macromolecular_Interacting_Partner_39_Specific_Function:
Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules

# Macromolecular_Interacting_Partner_39_Pathway:
Not Available

# Macromolecular_Interacting_Partner_39_Reaction:
Not Available

# Macromolecular_Interacting_Partner_39_Pfam_Domain_Function:
PF00474:SSF

# Macromolecular_Interacting_Partner_39_Signals:
1-446

# Macromolecular_Interacting_Partner_39_Transmembrane_Regions:
26-44
62-82
103-123
169-188
206-226
271-291
315-334
424-443
456-476
527-547
651-671

# Macromolecular_Interacting_Partner_39_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_39_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_39_GenBank_ID_Protein:
338053

# Macromolecular_Interacting_Partner_39_SwissProt_ID:
SC5A2_HUMAN (P31639)

# Macromolecular_Interacting_Partner_39_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_39_Genecard_id:
SLC5A2

# Macromolecular_Interacting_Partner_39_Geneatlas_id:
SLC5A2

# Macromolecular_Interacting_Partner_39_hgnc_id:
HGNC:11037

# Macromolecular_Interacting_Partner_39_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_39_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_39_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_39_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_39_Gene_Sequence:
>2019 bp
ATGGAGGAGCACACAGAGGCAGGCTCGGCACCAGAGATGGGGGCCCAGAAGGCCCTGATT
GACAATCCTGCTGACATCCTAGTCATTGCTGCATATTTCCTGCTGGTCATTGGCGTTGGC
TTGTGGTCCATGTGCAGAACCAACAGAGGCACTGTGGGCGGCTACTTCCTGGCAGGACGC
AGCATGGTGTGGTGGCCGGTTGGGGCCTCTCTCTTCGCCAGCAACATCGGCAGTGGCCAC
TTTGTGGGCCTGGCAGGGACTGGCGCTGCAAGTGGCTTGGCTGTTGCTGGATTCGAGTGG
AATGCGCTCTTCGTGGTGCTGCTACTGGGCTGGCTGTTTGCACCCGTGTACCTGACAGCG
GGGGTCATCACGATGCCACAGTACCTGCGCAAGCGCTTCGGCGGCCGCCGCATCCGCCTC
TACCTGTCTGTGCTCTCCCTTTTCCTGTACATCTTCACCAAGATCTCAGTGGACATGTTC
TCCGGAGCTGTATTCATCCAGCAGGCTCTGGGCTGGAACATCTATGCCTCCGTCATCGCG
CTTCTGGGCATCACCATGATTTACACGGTGACAGGAGGGCTGGCCGCGCTGATGTACACG
GACACGGTACAGACCTTCGTCATTCTGGGGGGCGCCTGCATCCTCATGGGTTACGCCTTC
CACGAGGTGGGCGGGTATTCGGGTCTCTTCGACAAATACCTGGGAGCAGCGACTTCGCTG
ACGGTGTCCGAGGATCCAGCCGTGGGAAACATCTCCAGCTTCTGCTATCGACCCCGGCCC
GACTCCTACCACCTGCTCCGGCACCCCGTGACCGGGGATCTGCCGTGGCCCGCGCTGCTC
CTCGGACTCACAATCGTCTCGGGCTGGTACTGGTGCAGCGACCAGGTCATCGTGCAGCGC
TGCCTGGCCGGGAAGAGCCTGACCCACATCAAGGCGGGCTGCATCCTGTGTGGGTACCTG
AAGCTGACGCCCATGTTTCTCATGGTCATGCCAGGCATGATCAGCCGCATTCTGTACCCA
GACGAGGTGGCGTGCGTGGTGCCTGAGGTGTGCAGGCGCGTGTGCGGCACGGAGGTGGGC
TGCTCCAACATCGCCTACCCGCGGCTCGTCGTGAAGCTCATGCCCAACGGTCTGCGCGGA
CTCATGCTGGCGGTCATGCTGGCCGCGCTCATGTCCTCGCTGGCCTCCATCTTCAACAGC
AGCAGCACGCTCTTCACCATGGACATCTACACGCGCCTGCGGCCACGCGCCGGCGACCGC
GAGCTGCTGCTGGTGGGACGGCTCTGGGTGGTGTTCATCGTGGTAGTGTCGGTGGCCTGG
CTTCCCGTGGTGCAGGCGGCACAGGGCGGGCAGCTCTTCGATTACATCCAGGCAGTCTCT
AGCTACCTGGCACCGCCCGTGTCCGCCGTCTTCGTGCTGGCGCTCTTCGTGCCGCGCGTT
AATGAGCAGGGCGCCTTCTGGGGACTCATCGGGGGCCTGCTGATGGGCCTGGCACGCCTG
ATTCCCGAGTTCTCCTTCGGCTCGGGCAGCTGTGTGCAGCCCTCGGCGTGCCCAGCTTTC
CTCTGCGGCGTGCACTACCTCTACTTCGCCATTGTGCTGTTCTTCTGCTCTGGCCTCCTC
ACCCTCACGGTCTCCCTGTGCACCGCGCCCATCCCCAGAAAGCACCTCCACCGCCTGGTC
TTCAGTCTCCGGCATAGCAAGGAGGAACGGGAGGACCTGGATGCTGATGAGCAGCAAGGC
TCCTCACTCCCTGTACAGAATGGGTGCCCAGAGAGTGCCATGGAGATGAATGAGCCCCAG
GCCCCGGCACCAAGCCTCTTCCGCCAGTGCCTGCTCTGGTTTTGTGGAATGAGCAGAGGT
GGGGTGGGCAGTCCTCCGCCCCTTACCCAGGAGGAGGCAGCGGCAGCAGCCAGGCGGCTG
GAGGACATCAGCGAGGACCCGAGCTGGGCCCGTGTGGTCAACCTCAATGCCCTGCTCATG
ATGGCAGTGGCCGTGTTCCTCTGGGGCTTCTATGCCTAA

# Macromolecular_Interacting_Partner_39_GenBank_ID_Gene:
M95549

# Macromolecular_Interacting_Partner_39_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_39_Locus:
16p12-p11

# Macromolecular_Interacting_Partner_39_SNPs:
rs3116150; rs3813008; rs9934336; rs11646054; rs3813007; rs12596304; rs1127723; rs28687124; rs35427854; rs34577144; rs3813006; rs9938609; rs4464099; rs3116149; rs34976954; rs9924771; rs5816530; rs9927039; rs35491084; rs10596; rs11150626; rs1127707; rs11865835; rs13143; rs34231527; rs34309878; rs36062238; rs4073483; rs4073484; rs4536493; rs7200926; rs9927250

# Macromolecular_Interacting_Partner_39_General_References:
1415574

# Macromolecular_Interacting_Partner_39_References:
Not Available

# Macromolecular_Interacting_Partner_40_ID:
8865

# Macromolecular_Interacting_Partner_40_Name:
Solute carrier family 2, facilitated glucose transporter member 6

# Macromolecular_Interacting_Partner_40_Synonyms:
Glucose transporter type 6; Glucose transporter type 9

# Macromolecular_Interacting_Partner_40_Gene_Name:
SLC2A6

# Macromolecular_Interacting_Partner_40_Protein_Sequence:
>Solute carrier family 2, facilitated glucose transporter member 6
MQEPLLGAEGPDYDTFPEKPPPSPGDRARVGTLQNKRVFLATFAAVLGNFSFGYALVYTS
PVIPALERSLDPDLHLTKSQASWFGSVFTLGAAAGGLSAMILNDLLGRKLSIMFSAVPSA
AGYALMAGAHGLWMLLLGRTLTGFAGGLTAACIPVYVSEIAPPGVRGALGATPQLMAVFG
SLSLYALGLLLPWRWLAVAGEAPVLIMILLLSFMPNSPRFLLSRGRDEEALRALAWLRGT
DVDVHWEFEQIQDNVRRQSSRVSWAEARAPHVCRPITVALLMRLLQQLTGITPILVYLQS
IFDSTAVLLPPKDDAAIVGAVRLLSVLIAALTMDLAGRKVLLFVSAAIMFAANLTLGLYI
HFGPRPLSPNSTAGLESESWGDLAQPLAAPAGYLTLVPLLATMLFIMGYAVGWGPITWLL
MSEVLPLRARGVASGLCVLASWLTAFVLTKSFLPVVSTFGLQVPFFFFAAICLVSLVFTG
CCVPETKGRSLEQIESFFRMGRRSFLR

# Macromolecular_Interacting_Partner_40_Number_of_Residues:
507

# Macromolecular_Interacting_Partner_40_Molecular_Weight:
54570

# Macromolecular_Interacting_Partner_40_Theoretical_pI:
8.77

# Macromolecular_Interacting_Partner_40_GO_Classification:
>>>
 Function:  carrier activity
Function:  electrochemical potential-driven transporter activity
Function:  porter activity
Function:  sugar porter activity
Function:  transporter activity
Function:  carbohydrate transporter activity
Function:  sugar transporter activity
Function:  monosaccharide transporter activity
Function:  hexose transporter activity
Function:  glucose transporter activity
 ||
>>>
 Process:  carbohydrate transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_40_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_40_Specific_Function:
Facilitative glucose transporter; binds cytochalasin B with low affinity

# Macromolecular_Interacting_Partner_40_Pathway:
Not Available

# Macromolecular_Interacting_Partner_40_Reaction:
Not Available

# Macromolecular_Interacting_Partner_40_Pfam_Domain_Function:
PF00083:Sugar_tr

# Macromolecular_Interacting_Partner_40_Signals:
Not Available

# Macromolecular_Interacting_Partner_40_Transmembrane_Regions:
38-58
82-102
112-132
141-161
169-189
195-215
290-310
315-335
340-360
396-416
436-456
463-483

# Macromolecular_Interacting_Partner_40_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_40_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_40_GenBank_ID_Protein:
9187482

# Macromolecular_Interacting_Partner_40_SwissProt_ID:
GTR6_HUMAN (Q9UGQ3)

# Macromolecular_Interacting_Partner_40_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_40_Genecard_id:
SLC2A6

# Macromolecular_Interacting_Partner_40_Geneatlas_id:
SLC2A6

# Macromolecular_Interacting_Partner_40_hgnc_id:
HGNC:11011

# Macromolecular_Interacting_Partner_40_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_40_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_40_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_40_Subcellular_Location:
Cell membrane; multi-pass membrane protein. Note=The dileucine internalization motif is critical for intracellular sequestration (By similarity)

# Macromolecular_Interacting_Partner_40_Gene_Sequence:
>1524 bp
ATGCAGGAGCCGCTGCTGGGAGCCGAGGGCCCGGACTACGACACCTTCCCCGAGAAGCCG
CCCCCGTCGCCAGGGGACAGGGCGCGGGTCGGGACCCTGCAGAACAAAAGGGTGTTCCTG
GCCACCTTCGCCGCAGTGCTCGGCAATTTCAGCTTTGGGTATGCCCTGGTCTACACATCC
CCTGTCATCCCAGCCCTGGAGCGCTCCTTGGATCCTGACCTGCATCTGACCAAATCCCAG
GCATCCTGGTTTGGGTCCGTGTTCACCCTGGGAGCAGCGGCCGGAGGCCTGAGTGCCATG
ATCCTCAACGACCTCCTGGGCCGGAAGCTGAGCATCATGTTCTCAGCTGTGCCGTCGGCG
GCCGGCTATGCGCTCATGGCGGGTGCGCACGGCCTCTGGATGCTGCTGCTCGGAAGGACG
CTGACGGGCTTCGCCGGGGGGCTCACAGCTGCCTGCATCCCGGTGTACGTGTCTGAGATT
GCTCCCCCAGGCGTTCGTGGGGCTCTGGGGGCCACACCCCAGCTCATGGCAGTGTTCGGA
TCCCTGTCCCTCTACGCCCTTGGCCTCCTGCTGCCGTGGCGCTGGCTGGCTGTGGCCGGG
GAGGCGCCTGTGCTCATCATGATCCTGCTGCTCAGCTTCATGCCCAACTCGCCGCGCTTC
CTGCTCTCTCGGGGCAGGGACGAAGAGGCCCTGCGGGCGCTGGCCTGGCTGCGTGGGACG
GACGTCGATGTCCACTGGGAGTTCGAGCAGATCCAGGACAACGTCCGGAGACAGAGCAGC
CGAGTATCGTGGGCTGAGGCACGGGCCCCACACGTGTGCCGGCCCATCACCGTGGCCTTG
CTGATGCGCCTCCTGCAGCAGCTGACGGGCATCACGCCCATCCTGGTCTACCTGCAGTCC
ATCTTCGACAGCACCGCTGTCCTGCTGCCCCCCAAGGACGACGCAGCCATCGTTGGGGCC
GTGCGGCTCCTGTCCGTGCTGATCGCCGCCCTCACCATGGACCTCGCAGGCCGCAAGGTG
CTGCTCTTCGTCTCAGCGGCCATCATGTTTGCTGCCAACCTGACTCTGGGGCTGTACATC
CACTTTGGCCCCAGGCCTCTGAGCCCCAACAGCACTGCGGGCCTGGAAAGCGAGTCCTGG
GGGGACTTGGCGCAGCCCCTGGCAGCACCCGCTGGCTACCTCACCCTGGTGCCCCTGCTG
GCCACCATGCTCTTCATCATGGGCTACGCCGTGGGCTGGGGTCCCATCACCTGGCTGCTC
ATGTCTGAGGTCCTGCCCCTGCGTGCCCGTGGCGTGGCCTCAGGGCTCTGCGTGCTGGCC
AGCTGGCTCACCGCCTTCGTCCTCACCAAGTCCTTCCTGCCAGTGGTGAGCACCTTCGGC
CTCCAGGTGCCTTTCTTCTTCTTCGCGGCCATCTGCTTGGTGAGCCTGGTGTTCACAGGC
TGCTGTGTGCCCGAGACCAAGGGACGGTCCCTGGAGCAGATCGAGTCCTTCTTCCGCATG
GGGAGAAGGTCCTTCTTGCGCTAG

# Macromolecular_Interacting_Partner_40_GenBank_ID_Gene:
Y17803

# Macromolecular_Interacting_Partner_40_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_40_Locus:
9q34

# Macromolecular_Interacting_Partner_40_SNPs:
rs2073935; rs3124759; rs968471; rs3124758; rs7032782; rs28477580; rs3094378; rs35885350; rs34209214; rs41309954; rs41297217; rs28584627; rs28653776; rs4962054; rs4962053; rs35051424; rs41307428; rs34285212; rs34676014; rs28681345; rs34008151; rs34780854; rs3094326; rs28393320; rs34913537; rs3124760; rs3124762; rs4962155; rs3124761; rs28615428; rs3124763; rs11454477; rs11288813; rs11338028; rs11432793; rs3124757; rs36124068; rs34251202; rs3094379; rs3124765; rs34048304; rs4962052; rs739467; rs739468; rs756820

# Macromolecular_Interacting_Partner_40_General_References:
10970791

# Macromolecular_Interacting_Partner_40_References:
Not Available

# Macromolecular_Interacting_Partner_41_ID:
8893

# Macromolecular_Interacting_Partner_41_Name:
Solute carrier family 2, facilitated glucose transporter member 8

# Macromolecular_Interacting_Partner_41_Synonyms:
Glucose transporter type 8; Glucose transporter type X1

# Macromolecular_Interacting_Partner_41_Gene_Name:
SLC2A8

# Macromolecular_Interacting_Partner_41_Protein_Sequence:
>Solute carrier family 2, facilitated glucose transporter member 8
MTPEDPEETQPLLGPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPP
APRLDDAAASWFGAVVTLGAAAGGVLGGWLVDRAGRKLSLLLCSVPFVAGFAVITAAQDV
WMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVVGILLAYLAGWVLE
WRWLAVLGCVPPSLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLWGSEQGWEDPPIGAE
QSFHLALLRQPGIYKPFIIGVSLMAFQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGV
IQVLFTAVAALIMDRAGRRLLLVLSGVVMVFSTSAFGAYFKLTQGGPGNSSHVAISAPVS
AQPVDASVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWLM
AFLVTKEFSSLMEVLRPYGAFWLASAFCIFSVLFTLFCVPETKGKTLEQITAHFEGR

# Macromolecular_Interacting_Partner_41_Number_of_Residues:
477

# Macromolecular_Interacting_Partner_41_Molecular_Weight:
50820

# Macromolecular_Interacting_Partner_41_Theoretical_pI:
7.68

# Macromolecular_Interacting_Partner_41_GO_Classification:
>>>
 Function:  carrier activity
Function:  electrochemical potential-driven transporter activity
Function:  porter activity
Function:  sugar porter activity
Function:  transporter activity
Function:  carbohydrate transporter activity
Function:  sugar transporter activity
Function:  monosaccharide transporter activity
Function:  hexose transporter activity
Function:  glucose transporter activity
 ||
>>>
 Process:  carbohydrate transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_41_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_41_Specific_Function:
Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose

# Macromolecular_Interacting_Partner_41_Pathway:
Not Available

# Macromolecular_Interacting_Partner_41_Reaction:
Not Available

# Macromolecular_Interacting_Partner_41_Pfam_Domain_Function:
PF00083:Sugar_tr

# Macromolecular_Interacting_Partner_41_Signals:
1-41

# Macromolecular_Interacting_Partner_41_Transmembrane_Regions:
26-46
71-91
97-117
128-148
157-177
183-203
257-277
293-313
320-340
368-388
405-425
439-459

# Macromolecular_Interacting_Partner_41_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_41_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_41_GenBank_ID_Protein:
7688146

# Macromolecular_Interacting_Partner_41_SwissProt_ID:
GTR8_HUMAN (Q9NY64)

# Macromolecular_Interacting_Partner_41_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_41_Genecard_id:
SLC2A8

# Macromolecular_Interacting_Partner_41_Geneatlas_id:
SLC2A8

# Macromolecular_Interacting_Partner_41_hgnc_id:
HGNC:13812

# Macromolecular_Interacting_Partner_41_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_41_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_41_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_41_Subcellular_Location:
Cell membrane; multi-pass membrane protein. Cytoplasmic vesicle; cytoplasmic vesicle membrane; multi-pass membrane protein (By similarity). Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration (By similarity)

# Macromolecular_Interacting_Partner_41_Gene_Sequence:
>1434 bp
ATGACGCCCGAGGACCCAGAGGAAACCCAGCCGCTTCTGGGGCCTCCTGGCGGCAGCGCG
CCCCGCGGCCGCCGCGTCTTCCTCGCCGCCTTCGCCGCTGCCCTGGGCCCACTCAGCTTC
GGCTTCGCGCTCGGCTACAGCTCCCCGGCCATCCCTAGCCTGCAGCGCGCCGCGCCCCCG
GCCCCGCGCCTGGACGACGCCGCCGCCTCCTGGTTCGGGGCTGTCGTGACCCTGGGTGCC
GCGGCGGGGGGAGTGCTGGGCGGCTGGCTGGTGGACCGCGCCGGGCGCAAGCTGAGCCTC
TTGCTGTGCTCCGTGCCCTTCGTGGCCGGCTTTGCCGTCATCACCGCGGCCCAGGACGTG
TGGATGCTGCTGGGGGGCCGCCTCCTCACCGGCCTGGCCTGCGGTGTTGCCTCCCTAGTG
GCCCCGGTCTACATCTCCGAAATCGCCTACCCAGCAGTCCGGGGGTTGCTCGGCTCCTGT
GTGCAGCTAATGGTCGTCGTCGGCATCCTCCTGGCCTACCTGGCAGGCTGGGTGCTGGAG
TGGCGCTGGCTGGCTGTGCTGGGCTGCGTGCCCCCCTCCCTCATGCTGCTTCTCATGTGC
TTCATGCCCGAGACCCCGCGCTTCCTGCTGACTCAGCACAGGCGCCAGGAGGCCATGGCC
GCCCTGCGGTTCCTGTGGGGCTCCGAGCAGGGCTGGGAAGACCCCCCCATCGGGGCTGAG
CAGAGCTTTCACCTGGCCCTGCTGCGGCAGCCCGGCATCTACAAGCCCTTCATCATCGGC
GTCTCCCTGATGGCCTTCCAGCAGCTGTCGGGGGTCAACGCCGTCATGTTCTATGCAGAG
ACCATCTTTGAAGAGGCCAAGTTCAAGGACAGCAGCCTGGCCTCGGTCGTCGTGGGTGTC
ATCCAGGTGCTGTTCACAGCTGTGGCGGCTCTCATCATGGACAGAGCAGGGCGGAGGCTG
CTCCTGGTCTTGTCAGGTGTGGTCATGGTGTTCAGCACGAGTGCCTTCGGCGCCTACTTC
AAGCTGACCCAGGGTGGCCCTGGCAACTCCTCGCACGTGGCCATCTCGGCGCCTGTCTCT
GCACAGCCTGTTGATGCCAGCGTGGGGCTGGCCTGGCTGGCCGTGGGCAGCATGTGCCTC
TTCATCGCCGGCTTTGCGGTGGGCTGGGGGCCCATCCCCTGGCTCCTCATGTCAGAGATC
TTCCCTCTGCATGTCAAGGGCGTGGCGACAGGCATCTGCGTCCTCACCAACTGGCTCATG
GCCTTTCTCGTGACCAAGGAGTTCAGCAGCCTCATGGAGGTCCTCAGGCCCTATGGAGCC
TTCTGGCTTGCCTCCGCTTTCTGCATCTTCAGTGTCCTTTTCACTTTTTCCTGTGTCCCT
GAAACTAAAGGAAAGACTCTGGAACAAATCACAGCCCATTTTGAGGGGCGATGA

# Macromolecular_Interacting_Partner_41_GenBank_ID_Gene:
Y17801

# Macromolecular_Interacting_Partner_41_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_41_Locus:
9q33.3

# Macromolecular_Interacting_Partner_41_SNPs:
rs1138740; rs1138739; rs3088163; rs6635; rs3824414; rs3802364; rs3824413; rs3802368; rs10819287; rs11788710; rs4075850; rs3802367; rs3802363; rs4837150; rs11789887; rs11790967; rs3808835; rs3808838; rs3808839; rs10819288; rs3808836; rs7859247; rs10987632; rs41276194; rs34064803; rs36057295; rs34424745; rs3802366; rs4075298; rs7853132; rs5900746; rs35278243; rs34710554; rs35020051; rs28730350; rs35116441; rs41276196; rs10987637; rs34516407; rs10987633; rs10987635; rs13286516; rs10987636; rs12115375; rs28463013; rs41302651; rs41276192; rs7031934; rs3840734; rs3808840; rs11552814; rs3808837; rs35090919; rs11790936; rs10819289; rs10987630; rs10987639; rs10987640; rs1127518; rs35789340; rs4074695; rs7047760; rs7848126; rs7864853; rs7873847

# Macromolecular_Interacting_Partner_41_General_References:
10821868; 10671487

# Macromolecular_Interacting_Partner_41_References:
Not Available

End of HMDB00122

Beginning of HMDB00123
# Accession_No:
HMDB00123

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-19 11:10:29

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Glycine

# Description:
Glycine is a simple, nonessential amino acid, although experimental animals show reduced growth on low-glycine diets. The average adult ingests 3 to 5 grams of glycine daily. Glycine is involved in the body's production of DNA, phospholipids and collagen, and in release of energy. Glycine levels are effectively measured in plasma in both normal patients and those with inborn errors of glycine metabolism. (http://www.dcnutrition.com/AminoAcids/) Nonketotic hyperglycinaemia (OMIM 606899) is an autosomal recessive condition caused by deficient enzyme activity of the glycine cleavage enzyme system (EC 2.1.1.10). The glycine cleavage enzyme system comprises four proteins: P-, T-, H- and L-proteins (EC 1.4.4.2, EC 2.1.2.10 and EC 1.8.1.4 for P-, T- and L-proteins). Mutations have been described in the GLDC (OMIM 238300), AMT (OMIM 238310), and GCSH (OMIM 238330) genes encoding the P-, T-, and H-proteins respectively. The glycine cleavage system catalyses the oxidative conversion of glycine into carbon dioxide and ammonia, with the remaining one-carbon unit transferred to folate as methylenetetrahydrofolate. It is the main catabolic pathway for glycine and it also contributes to one-carbon metabolism. Patients with a deficiency of this enzyme system have increased glycine in plasma, urine and cerebrospinal fluid (CSF) with an increased CSF: plasma glycine ratio. (PMID 16151895)

# Synonyms:
2-Aminoacetate; 2-Aminoacetic acid; Aciport; Aminoacetate; Aminoacetic acid; Aminoethanoate; Aminoethanoic acid; Glicoamin; Glycocoll; Glycolixir; Glycosthene; Gyn-Hydralin; Padil; amino-Acetate; amino-Acetic acid

# Chemical_IUPAC_Name:
2-aminoacetic acid

# Chemical_Formula:
C2H5NO2

# Chemical_Structure:
tbl_chemical:::HMDB00123_ZOOM.png:::119283201714329768

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00123_THUMB.png:::11928320157678858

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids; Nitrogenous Compounds

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid; alpha-aminoacid

# Taxonomy_Biofunction:
Non-essential amino acid

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
75.03203

# Molecular_Weight_Avg:
75.06660

# Smiles_String_isomeric:
NCC(O)=O

# Smiles_String_canonical:
NCC(O)=O

# KEGG_Compound_ID:
C00037

# BioCyc_ID:
GLY

# PubChem_CID:
750

# PubChem_SID:
836139; 3133349; 545913; 6435754; 833865; 3339; 838484; 11528254; 841093; 2766; 11532286; 7346033; 825952; 7852159; 854398; 585843; 538544; 8138085; 626974; 589752; 698673; 8026292; 10323812; 86929; 148775; 10527483; 827141; 835607; 11113413; 824436; 836630; 824434; 829387; 547892; 830123; 821083; 7887927; 827472; 545683; 7979426; 8145759; 7847079; 579047; 8026825; 836631; 8150769; 829229; 7989223; 579046

# OMIM_ID:
605899

# Metagene_ID:
EPEMA SYNDROME (ENCEPHALOPATHY, PETECHIAE, ETHYLMALONIC ACIDURIA): 274; 4-HYDROXYBUTYRIC ACIDURIA: 7; IMINOGLYCINURIA: 99; VALPROATE THERAPY: ANTICONVULASANT HYPERSENSITIVITY SYNDROME VALPROATE ASSOCIATED HEPATOTOXICITY: 324; 2-METHYL-3-HYDROXYBUTYRYL-CoA DEHYDROGENASE DEFICIENCY: 457; PROPIONIC ACIDEMIA. KETOTIC HYPERGLYCINEMIA (PA): 18; GLUCOGLYCINURIA: 297; 3-METHYL-CROTONYL-GLYCINURIA: 27; ARGININOSUCCINIC ACIDURIA (ASL): 25; HYPERPROLINEMIA, TYPE II: 240; SHORT CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD): 40; 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY: 377; CITRULLINEMIA TYPE I. ASS: 92; HYDROXYPROLINEMIA: 201; ISOVALERIC ACIDEMIA: 10; SOTOS SYNDROME: 423; AMINOACYLASE I DEFICIENCY: 516; ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC): 189; HYPERGLYCINEMIA, NON-KETOTIC: 207; METHYLMALONIC ACIDURIA, cblA TYPE: 328; ARTEFACTS-PHARMACEUTICAL PRODUCTS, INTERFERENCE IN AMINOACID AND ORGANIC ACID ANALYSIS [DD]: 347; FEEDING: AMINO ACID FORMULA [DD]: 341; MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM: 79; CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY (CPS): 77; HYPERPROLINEMIA, TYPE I: 219; DIMETHYLGLYCINURIA: 508; SHORT/BRANCHED-CHAIN ACYL-CoA DEHYDROGENASE DEFICIENCY: 479; MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD): 39; D-GLYCERIC ACIDURA: 114; ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY: 509; GLUTARIC ACIDURIA II: 9; METHYLMALONIC ACIDURIA (MMA): 15; 3-HYDROXY-3-METHYLGLUTARYL-CoA LYASE DEFICIENCY: 4; CYSTINYLGLYCINURIA: 498; BIOTINIDASE DEFICIENCY: 73; NEWBORNS, PREMATURE INFANTS, TRANSIENT IMMATURITY OF TRANSPORT SYSTEMS OR ENZYMES: 340; CONGENITAL DISORDER OF GLYCOSYLATION CDG-Ia: 293; BETA-KETOTHIOLASE DEFICIENCY: 5

# BiGG_ID:
33610

# Wikipedia_ID:
Glycine

# METLIN_ID:
20

# Ref_ID:
11159884; 16390611; 15911239; 12297216; 14992292; 9639330; 14622583; 16686720; 8888048; 8456092; 12097436; 2026685; 6696735; 16453318; 11569574; 12834252; 15780050; 6321058; 6198473

# ChEBI_ID:
15428

# CAS_Registry_Number:
56-40-6

# InChI:
InChI=1/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

# Synthesis_Reference:
Synthesis of glycine.     Anslow, Winston K.; King, Harold.    Journal of the Chemical Society  (1929),     2163-6.

# Melting_Point:
504 deg F

# Melting_Point_predicted:
25.4 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
249.0 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
552.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-3.21 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-3.33 [Predicted by ALOGPS]; -3.4 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Glycine.pdf:::1132562203013169445

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Glycine.mol:::1132723808328881441

# SDF_File_[Text]:
tbl_chemical:::HMDB00123.sdf:::119283201282225049

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00123.pdb:::119283201440286504

# PDB_ID:
1CVI

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041023_P00_02_HW_1DP_PRESAT_expanded_2.gif:::114460741945455747

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041023_P00_02_HW_1DP_presat.zip:::1177710615905250167

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041023_P00_02_HW_1DP_Assigned.png:::114660647399172451

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::041023_P00_02_HW_1DC_58.jpg:::114168459869989045

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041023_P00_02_HW_1DC_58.zip:::114168459866440706

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041023_P00_02_HW_1DC_58_Assigned.jpg:::11432293304512976

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041023_P00_02_HW_2DHSQC_184.jpg:::114495884578749490

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041023_P00_02_HW_2DHSQC_184.zip:::114495884579783964

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041023_P00_02_HW_2DHSQC_184_Assigned.jpg:::114546614443932820

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Glycine.gif:::1132732111000950288

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00123_peaks.txt:::1156309558596343389

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Glycine_C.gif:::1132737690735251186

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00123_peaks.txt:::1156310748678635294

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00123L.png:::11755526270323677; Medium Energy:tbl_ms:::HMDB00123M.png:::11755526807864669; High Energy:tbl_ms:::HMDB00123H.png:::11755527151084463

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000089.png:::116890826390698314

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000089.txt:::116890826420316153

# Cellular_Location:
Cytoplasm (Predicted from LogP); Extracellular; lysosome; mitochondria; peroxisome

# Tissue_Location:
Bladder; Brain; Epidermis; Fibroblasts; Intestine; Kidney; Myelin; Neurons; Pancreas; Placenta; Platelet; Prostate; Spleen; Stratum Corneum; Thyroid Gland

# deuterated:
No

# Biofluid_Location:
Bile; Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Urine	151.0 (480.0-233.0)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	6321058
Urine	513.54 +/- 360.61	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	2026685
Blood	242.0 +/- 44.0	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 93. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	258.0 +/- 64.0	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 93. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	280.0 (140.0-420.0)	uM	Newborn:0-30_days_old	Both	Normal	8888048
Blood	230.0 (178.0-282.0)	umol/L	Adult:>18_yrs_old	Both	Normal	12297216
Blood	460.0 +/- 275.0	umol/L	Newborn:0-30_days_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	234.0 +/- 34.0	umol/L	Children:1-13_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	4.7 +/- 1.5	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	39.0 +/- 23.0	uM	Adult:>18_yrs_old	Both	Normal	HMP Experimental
Cerebrospinal_Fluid(CSF)	9.0 (3.0-19.0)	umol/L	Adult:>18_yrs_old	Both	Normal	16390611
Cerebrospinal_Fluid(CSF)	9.5 +/- 4.7	umol/L	Adult:>18_yrs_old	N/A	Normal	15911239
Cerebrospinal_Fluid(CSF)	8.2 +/- 3.0	umol/L	Adult:>18_yrs_old	N/A	Normal	6198473
Cerebrospinal_Fluid(CSF)	8.30 (5.88-10.7)	umol/L	Adult:>18_yrs_old	Both	Normal	12834252
Saliva	>10	umol/L	Adult:>18_yrs_old	Both	Normal	12097436
Bile	>10	umol/L	Adult:>18_yrs_old	Both	Normal	15780050


# Concentration_[Abnormal]:
Urine	84.0 +/- 67.0	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Lung Cancer	
Blood	1090.0 (780.0-1400.0)	uM	Newborn:0-30_days_old	Both	Non-ketotic hyperglycinemia	8888048
Blood	170	umol/L	Adult:>18_yrs_old	Both	Diabetes	6696735
Blood	210.0 (203.0-217.0)	umol/L	Adult:>18_yrs_old	Both	Refractory localization-related epilepsy (RLE)	14992292
Blood	354.0 (309.0-399.0)	umol/L	Adult:>18_yrs_old	Both	Juvenile myoclonic epilepsy (JME)	14992292
Cerebrospinal_Fluid(CSF)	9.7 +/- 4.9	umol/L	N/A	N/A	leukemia	15911239
Cerebrospinal_Fluid(CSF)	13.4 +/- 6.4	umol/L	N/A	N/A	leukemia with CNS disease	15911239


# Associated_Disorders:
3-Phosphoglycerate Dehydrogenase Deficiency; 4-Hydroxybutyric Aciduria; Adenosylcobalamin Deficiency (CBLA, CBLB); Argininosuccinic Aciduria (ASL); Aseptic meningitis; Astrocytoma; Beta-Ketothiolase Deficiency; Carbamoyl Phosphate Synthetase Deficiency (CPS); Citrullinemia Type I; D-Glyceric Acidura; Diabetes; Glioblastomas; Hydroxyprolinemia; Hyperglycinemia, Non-Ketotic; Iminoglycinuria; Isovaleric Acidemia; Juvenile myoclonic epilepsy (JME); Ketotic Hyperglycinemia (PA); leukemia; leukemia with CNS disease; Lung Cancer; Methylmalonic Aciduria (MMA); Non-ketotic hyperglycinemia; Ornithine Transcarbamylase Deficiency (OTC); Periodontitis; Propionic Acidemia; Refractory localization-related epilepsy (RLE); Sotos Syndrome; Tuberculous meningitis; Valproate Therapy: Anticonvulasant Hypersensitivity Syndrome Valproate Associated Hepatotoxicity

# Pathway_Names:
One carbon pool by folate;Folate biosynthesis

# Pathway_Images:
;

# KEGG_Images:
map00670;map00790

# Pathway_Graphs:
;

# Pathway_SBMLs:
;

# Metabolic_Enzyme_1_ID:
6070

# Metabolic_Enzyme_1_Name:
Dihydrofolate reductase

# Metabolic_Enzyme_1_Synonyms:
Not Available

# Metabolic_Enzyme_1_Gene_Name:
DHFR

# Metabolic_Enzyme_1_Protein_Sequence:
>Dihydrofolate reductase
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND

# Metabolic_Enzyme_1_Number_of_Residues:
187

# Metabolic_Enzyme_1_Molecular_Weight:
21453

# Metabolic_Enzyme_1_Theoretical_pI:
7.60

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NADP binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
Function:  dihydrofolate reductase activity
 ||
>>>
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
Process:  glycine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8- dihydrofolate + NADPH

# Metabolic_Enzyme_1_Pathway:
map00670  One carbon pool by folate;
 map00790  Folate biosynthesis

# Metabolic_Enzyme_1_Reaction:
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00186:DHFR_1

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.5.1.3

# Metabolic_Enzyme_1_GenBank_ID_Protein:
182724

# Metabolic_Enzyme_1_SwissProt_ID:
DYR_HUMAN (P00374)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
DHFR

# Metabolic_Enzyme_1_Geneatlas_id:
DHFR

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2861

# Metabolic_Enzyme_1_PDB_ID:
1MVT

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>564 bp
ATGGTTGGTTCGCTAAACTGCATCGTCGCTGTGTCCCAGAACATGGGCATCGGCAAGAAC
GGGGACCTGCCCTGGCCACCGCTCAGGAATGAATTCAGATATTTCCAGAGAATGACCACA
ACCTCTTCAGTAGAAGGTAAACAGAATCTGGTGATTATGGGTAAGAAGACCTGGTTCTCC
ATTCCTGAGAAGAATCGACCTTTAAAGGGTAGAATTAATTTAGTTCTCAGCAGAGAACTC
AAGGAACCTCCACAAGGAGCTCATTTTCTTTCCAGAAGTCTAGATGATGCCTTAAAACTT
ACTGAACAACCAGAATTAGCAAATAAAGTAGACATGGTCTGGATAGTTGGTGGCAGTTCT
GTTTATAAGGAAGCCATGAATCACCCAGGCCATCTTAAACTATTTGTGACAAGGATCATG
CAAGACTTTGAAAGTGACACGTTTTTTCCAGAAATTGATTTGGAGAAATATAAACTTCTG
CCAGAATACCCAGGTGTTCTCTCTGATGTCCAGGAGGAGAAAGGCATTAAGTACAAATTT
GAAGTATATGAGAAGAATGATTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
J00140

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_1_Locus:
5q11.2-q13.2

# Metabolic_Enzyme_1_SNPs:
rs1643630; rs2618372; rs1643650; rs6875184; rs10072026; rs11951910; rs836818; rs1643638; rs1677693; rs1643658; rs10078190; rs836823; rs836821; rs1643659; rs1677691; rs1643635; rs1677694; rs1677634; rs13161245; rs865646; rs1677633; rs844370; rs10052238; rs966762; rs865647; rs1650709; rs2431221; rs10054574; rs34965641; rs865645; rs1643649; rs525054; rs245104; rs11951283; rs1650700; rs1650711; rs245099; rs1650710; rs6453522; rs1677700; rs372069; rs34563643; rs1677696; rs1650714; rs1643664; rs864133; rs1623489; rs1650701; rs35709834; rs1677661; rs11742668; rs836819; rs861373; rs1677692; rs836822; rs860717; rs34781740; rs1677701; rs1650706; rs1650713; rs2560424; rs863216; rs2897261; rs1643657; rs1643661; rs1643634; rs1677666; rs12517451; rs1650723; rs12109877; rs1650720; rs14435; rs11112; rs1053136; rs11550953; rs1129240; rs1129243; rs2431220; rs7387; rs190293; rs34764978; rs35262215; rs1129242; rs34087552; rs10685456; rs1650717; rs13182730; rs1677706; rs10474631; rs34268388; rs35740086; rs6863377; rs10076523; rs2545005; rs1677704; rs1643662; rs1643647; rs1677697; rs7706270; rs10557831; rs2560423; rs3958540; rs863217; rs1677699; rs1643637; rs165957; rs3991269; rs4406117; rs34545755; rs3991268; rs245101; rs11305000; rs1643656; rs1677636; rs1677684; rs11490741; rs1650712; rs34132382; rs1677705; rs2897260; rs1677688; rs3958541; rs34289983; rs863215; rs1677686; rs1650707; rs34468903; rs1650715; rs245103; rs34184316; rs1677702; rs34288321; rs35372305; rs34122957; rs1643660; rs7705115; rs34674884; rs2434329; rs10942929; rs2927911; rs1650716; rs7706404; rs3797876; rs2405873; rs1222967; rs245105; rs1677689; rs34359040; rs11749051; rs1643648; rs2560422; rs1650718; rs1677631; rs10942928; rs34504711; rs11952744; rs3958542; rs35633165; rs1643636; rs836820; rs1650708; rs245100; rs7725721; rs34141487; rs11491447; rs1643663; rs34540063; rs8180493; rs1677687; rs1677695; rs33948142; rs1677685; rs13165178; rs10077031; rs34143020; rs390975; rs12109309; rs10168; rs10474632; rs1105524; rs1222809; rs1232027; rs1382539; rs1382540; rs1382541; rs1382542; rs1478834; rs1478835; rs1643639; rs1643641; rs1643646; rs1643655; rs1650675; rs1650676; rs1650681; rs1650692; rs1650694; rs1650695; rs1650696; rs1650697; rs1677626; rs1677667; rs1677670; rs1677682; rs1677703; rs245102; rs380691; rs3822706; rs384925; rs408626; rs442767; rs453544; rs6878815; rs6897872; rs701383; rs861365

# Metabolic_Enzyme_1_General_References:
6323448; 6687716; 6235374; 3383852; 2248959; 9374868; 1731871

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
8860

# Metabolic_Enzyme_2_Name:
PIPOX protein

# Metabolic_Enzyme_2_Synonyms:
Not Available

# Metabolic_Enzyme_2_Gene_Name:
PIPOX

# Metabolic_Enzyme_2_Protein_Sequence:
>PIPOX protein
MAAQKDLWDAIVIGAGIQGCFTAYHLAKHRKRILLLEQFFLPHSRGSSHGQSRIIRKAYL
EDFYTRMMHECYQIWAQLEHEAGTQLHRQTGLLLLGMKENQELKTIRANLSRQRVEHQCL
SSEELKQRFPNIRLPRGEVGLLDNSGGVIYAYKALRALQDAIRQLGGIVRDGEKVVEINP
GLLVTVKTTSRSYQAKSLVITAGPWTNQLLRPLGIEMPLQTLRINVCYWREMVPGSYGVS
QAFPCFLWLGLCPHHIYGLPTGEYPGLMKVSYHHGNHADPEERDCPTARTDIGDVQILSS
FVRDHLPDLKPEPAVIESCMYTNTPDEQFILDRHPKYDNIVIGAGFSGHGFKLAPVVGKI
LYELSMKLTPSYDLAPFRISRFPSLAKAHL

# Metabolic_Enzyme_2_Number_of_Residues:
390

# Metabolic_Enzyme_2_Molecular_Weight:
44109

# Metabolic_Enzyme_2_Theoretical_pI:
8.68

# Metabolic_Enzyme_2_GO_Classification:
>>>
 Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor
Function:  sarcosine oxidase activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
 Process:  aromatic compound metabolism
Process:  folic acid and derivative metabolism
Process:  tetrahydrofolate metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism

# Metabolic_Enzyme_2_Specific_Function:
Not Available

# Metabolic_Enzyme_2_Pathway:
Not Available

# Metabolic_Enzyme_2_Reaction:
Not Available

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01266:DAO

# Metabolic_Enzyme_2_Signals:
Not Available

# Metabolic_Enzyme_2_Transmembrane_Regions:
7-26

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.5.3.1;EC 1.5.3.7

# Metabolic_Enzyme_2_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_2_SwissProt_ID:
Q6IAJ9_HUMAN (Q6IAJ9)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
PIPOX

# Metabolic_Enzyme_2_Geneatlas_id:
PIPOX

# Metabolic_Enzyme_2_hgnc_id:
HGNC:17804

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Membrane

# Metabolic_Enzyme_2_Gene_Sequence:
Not Available

# Metabolic_Enzyme_2_GenBank_ID_Gene:
CR457155

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_2_Locus:
17q11.2

# Metabolic_Enzyme_2_SNPs:
rs9890082; rs9912656; rs8081500; rs8067658; rs9908931; rs8067401; rs7211084; rs17795242; rs8077381; rs6505106; rs8066520; rs11869504; rs8078346; rs4795491; rs3736253; rs12325690; rs7225763; rs7217905; rs11868047; rs7211375; rs12326022; rs6505105; rs4794849; rs11869124; rs11869243; rs7213119; rs17852448; rs17856772; rs17856771; rs17856770; rs17852449; rs7223527; rs34642085; rs35277021; rs11291050; rs5819860; rs35037948; rs35675206; rs11424309; rs35805984; rs3884011; rs33913117; rs9899482; rs8074269; rs35121520; rs7224285; rs34991975; rs11404274; rs35812484; rs11652008; rs34431204; rs35429458; rs34830053; rs33927135; rs35145427; rs11386770; rs35719076; rs11653331; rs11655979; rs11869703; rs11869891; rs12150489; rs12936749; rs1319486; rs16964766; rs173248; rs184735; rs189460; rs191562; rs192126; rs193239; rs239268; rs4965971; rs507040; rs507917; rs507949; rs545347; rs546127; rs560156; rs637579; rs7209257; rs7209803; rs7220662; rs7221150; rs8064530; rs8069593; rs8070009; rs8076228; rs8081869; rs8082295; rs9898869; rs9913000

# Metabolic_Enzyme_2_General_References:
Not Available

# Metabolic_Enzyme_2_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8479

# Macromolecular_Interacting_Partner_1_Name:
Asc-type amino acid transporter 1

# Macromolecular_Interacting_Partner_1_Synonyms:
Asc-1

# Macromolecular_Interacting_Partner_1_Gene_Name:
SLC7A10

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Asctype amino acid transporter 1
MAGHTQQPSGRGNPRPAPSPSPVPGTVPGASERVALKKEIGLLSACTIIIGNIIGSGIFI
SPKGVLEHSGSVGLALFVWVLGGGVTALGSLCYAELGVAIPKSGGDYAYVTEIFGGLAGF
LLLWSAVLIMYPTSLAVISMTFSNYVLQPVFPNCIPPTTASRVLSMACLMLLTWVNSSSV
RWATRIQDMFTGGKLLALSLIIGVGLLQIFQGHFEELRPSNAFAFWMTPSVGHLALAFLQ
GSFAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELLSSN
AVAVTFGEKLLGYFSWVMPVSVALSTFGGINGYLFTYSRLCFSGAREGHLPSLLAMIHVR
HCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLLLRWRRPALHRPI
KVNLLIPVAYLVFWAFLLVFSFISEPMVCGVGVIIILTGVPIFFLGVFWRSKPKCVHRLT
ESMTHWGQELCFVVYPQDAPEEEENGPCPPSLLPATDKPSKPQ

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
523

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
56799

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
8.24

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
 Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_1_Specific_Function:
Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_1_Signals:
1-136

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
40-60
72-92
113-133
268-288
310-330
362-382
388-408
424-444
448-468

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
9309293

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
AAA1_HUMAN (Q9NS82)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
SLC7A10

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
SLC7A10

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:11058

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; multi-pass membrane protein (Probable)

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1572 bp
ATGGCCGGCCACACGCAGCAGCCGAGCGGGCGCGGGAACCCCAGGCCTGCGCCCTCGCCC
TCCCCAGTCCCAGGGACCGTCCCCGGCGCCTCGGAGCGGGTGGCGCTCAAGAAGGAGATC
GGGCTGCTGAGCGCCTGCACCATCATCATCGGGAACATCATCGGCTCGGGCATCTTCATC
TCGCCCAAGGGGGTCCTGGAGCACTCAGGCTCCGTGGGTCTGGCCCTGTTCGTCTGGGTC
CTGGGTGGGGGCGTGACGGCTCTGGGCTCCCTCTGCTATGCAGAGCTGGGAGTCGCCATC
CCCAAGTCTGGCGGGGACTACGCCTACGTCACAGAGATCTTCGGGGGCCTGGCTGGCTTT
CTGCTGCTCTGGAGCGCCGTCCTCATCATGTACCCCACCAGCCTTGCTGTCATCTCCATG
ACCTTCTCCAACTACGTGCTGCAGCCCGTGTTCCCCAACTGCATCCCCCCCACCACAGCC
TCCCGGGTGCTGTCCATGGCCTGCCTGATGCTCCTGACATGGGTGAACAGCTCCAGTGTG
CGCTGGGCCACGCGCATCCAGGACATGTTCACAGGCGGGAAGCTGCTGGCCTTGTCCCTC
ATCATCGGCGTGGGCCTTCTCCAGATCTTCCAAGGACACTTCGAGGAGCTGAGGCCCAGC
AATGCCTTTGCTTTCTGGATGACGCCCTCCGTGGGACACCTGGCCCTGGCCTTCCTCCAG
GGCTCCTTCGCCTTCAGTGGCTGGAACTTCCTCAACTATGTCACCGAGGAGATGGTTGAC
GCCCGAAAGAACCTACCTCGCGCCATCTTCATCTCCATCCCACTGGTGACCTTCGTGTAC
ACGTTCACCAACATTGCCTACTTCACGGCCATGTCCCCCCAGGAGCTGCTCTCCTCCAAT
GCGGTGGCTGTGACCTTCGGGGAGAAGCTGCTGGGCTACTTTTCTTGGGTCATGCCTGTC
TCCGTGGCTCTGTCAACCTTCGGAGGGATCAATGGTTACCTGTTCACCTACTCCAGGCTG
TGCTTCTCTGGAGCCCGCGAGGGGCACCTGCCCAGCCTGCTGGCCATGATCCACGTCAGA
CACTGCACCCCCATCCCCGCCCTCCTCGTCTGTTGCGGGGCCACAGCCGTCATCATGCTC
GTGGGCGACACGTACACGCTCATCAACTATGTGTCCTTCATCAACTACCTCTGCTACGGC
GTCACCATCCTGGGCCTGCTGCTGCTGCGCTGGAGGCGGCCTGCACTCCACAGGCCCATC
AAGGTGAACCTTCTCATCCCCGTGGCGTACTTGGTCTTCTGGGCCTTCCTGCTGGTCTTC
AGCTTCATCTCAGAGCCTATGGTCTGTGGGGTCGGCGTCATCATCATCCTTACGGGGGTG
CCCATTTTCTTTCTGGGAGTGTTCTGGAGAAGCAAACCAAAGTGTGTGCACAGACTCACA
GAGTCCATGACACACTGGGGCCAGGAGCTGTGTTTCGTGGTCTACCCCCAGGACGCCCCC
GAAGAGGAGGAGAATGGCCCCTGCCCACCCTCCCTGCTGCCTGCCACAGACAAGCCCTCG
AAGCCACAATGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AB037670

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_1_Locus:
19q13.1

# Macromolecular_Interacting_Partner_1_SNPs:
rs34663170; rs2303094; rs4805031; rs7258412; rs12609177; rs8106493; rs1974807; rs10406787; rs8101891; rs7254894; rs12609763; rs7508758; rs3786926; rs2303093; rs8106375; rs4407170; rs3786927; rs2241378; rs8105889; rs11669156; rs1009175; rs11673535; rs16967863; rs11671790; rs34454261; rs8105887; rs12972369; rs11084715; rs4805030; rs4516343; rs8110876; rs35557280; rs16967861; rs12972468; rs11878801; rs11666788; rs10417375; rs726822; rs1465424; rs4330029; rs4553741; rs7251684; rs889102; rs7249980; rs35390810; rs11542481; rs34961684; rs8107888; rs12151336; rs11670702; rs34937345; rs34203180; rs889101; rs34180473; rs10555903; rs12982023; rs33951856; rs4805862; rs11882613; rs11879325; rs34981363; rs11378328; rs8107002; rs11880750; rs34309383; rs5827838; rs35763570; rs35887187; rs7248380; rs34843019; rs11455629; rs28419758; rs35055563; rs35775570; rs35756066; rs11671925; rs34257327; rs10667670; rs34645339; rs36212687; rs3064210; rs5827839; rs11448774; rs5827841; rs3064187; rs5827842; rs889103; rs36216474; rs10410558; rs10412342; rs1056034; rs1056041; rs1107920; rs1107921; rs11084712; rs11666900; rs11671345; rs11672303; rs11673115; rs1559182; rs17694094; rs17760699; rs17848212; rs1862464; rs2112800; rs2194169; rs2303095; rs2303096; rs34138351; rs34158692; rs34529542; rs35831673; rs36029918; rs3745974; rs3745975; rs3745976; rs3745977; rs3745978; rs4444444; rs4805863; rs7359893; rs8100642; rs875550

# Macromolecular_Interacting_Partner_1_General_References:
10863037; 11509015

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8486

# Macromolecular_Interacting_Partner_2_Name:
Dimethylglycine dehydrogenase-like protein isoform 1

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Dimethylglycine dehydrogenaselike protein isoform 1
MASLSRALRVAAAHPRQSPTRGMGPCNLSSAAGPTAEKSVPYQRTLKEGQGTSVVAQGPS
RPLPSTANVVVIGGGSLGCQTLYHLAKLGMSGAVLLERERLTSGTTWHTAGLLWQLRPSD
VEVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESH
VLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGI
RVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTER
IEGIQNMPNVRDHDASVYLRLQGDALSVGGYEANPIFWEEVSDKFAFGLFDLDWEVFTQH
IEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCGFNSAGKVQTVLP
LLFTVNVYLYL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
431

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
46610

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.98

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_2_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF01266:DAO

# Macromolecular_Interacting_Partner_2_Signals:
Not Available

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
4235222

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
O95173_HUMAN (O95173)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:10536

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1296 bp
ATGGCCTCACTGAGCCGAGCCCTACGTGTGGCTGCTGCCCACCCTCGCCAGAGCCCTACC
CGGGGCATGGGGCCATGCAACCTGTCCAGCGCAGCTGGCCCCACAGCCGAGAAGAGTGTG
CCATATCAGCGGACCCTGAAGGAGGGACAGGGCACCTCGGTGGTGGCCCAAGGCCCAAGC
CGGCCCCTGCCCAGCACGGCCAACGTGGTGGTCATTGGTGGAGGCAGCTTGGGCTGCCAG
ACCCTGTACCACCTGGCCAAGCTGGGCATGAGTGGGGCGGTGCTGCTGGAGCGGGAGCGG
CTGACCTCCGGGACCACCTGGCACACGGCAGGCCTGCTGTGGCAGCTGCGGCCCAGTGAC
GTGGAGGTGGAGCTTCTGGCCCACACTCGGCGGGTGGTGAGCCGGGAGCTGGAGGAGGAG
ACGGGACTACACACGGGCTGGATCCAGAATGGGGGCCTCTTCATCGCGTCCAACCGGCAG
CGCCTGGACGAGTACAAGAGGCTCATGTCGCTGGGCAAGGCGTATGGTGTGGAATCCCAT
GTGCTGAGCCCGGCAGAGACCAAGACTCTGTACCCGCTGATGAATGTGGACGACCTCTAC
GGGACCCTGTATGTGCCGCACGACGGTACCATGGACCCCGCTGGCACCTGTACCACCCTC
GCCAGGGCAGCTTCTGCCCGAGGAGCACAGGTCATTGAGAACTGCCCAGTGACCGGCATT
CGTGTGTGGACGGATGATTTTGGGGTGCGGCGGGTCGCGGGTGTGGAGACTCAGCATGGT
TCCATCCAGACACCCTGCGTGGTCAATTGTGCAGGAGTGTGGGCAAGTGCTGTGGGCCGG
ATGGCTGGAGTCAAGGTCCCGCTGGTGGCCATGCACCATGCCTATGTCGTCACCGAGCGC
ATCGAGGGGATTCAGAACATGCCCAATGTCCGTGATCATGATGCCTCTGTCTACCTCCGC
CTCCAAGGGGATGCCTTGTCTGTGGGTGGCTATGAGGCCAACCCCATCTTTTGGGAGGAG
GTGTCAGACAAGTTTGCCTTCGGCCTCTTTGACCTGGACTGGGAGGTGTTCACCCAGCAC
ATTGAAGGCGCCATCAACAGGGTCCCCGTGCTGGAGAAGACAGGAATCAAGTCCACGGTC
TGCGGCCCTGAATCCTTCACGCCCGACCACAAGCCCCTGATGGGGGAGGCACCTGAGCTC
CGAGGGTTCTTCCTGGGCTGTGGCTTCAACAGCGCAGGGAAGGTCCAGACAGTCCTGCCA
CTCCTGTTTACCGTCAACGTCTATCTGTATCTGTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AF047004

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Locus:
Not Available

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
Not Available

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8518

# Macromolecular_Interacting_Partner_3_Name:
Proton-coupled amino acid transporter 1

# Macromolecular_Interacting_Partner_3_Synonyms:
Proton/amino acid transporter 1; Solute carrier family 36 member 1

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC36A1

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Protoncoupled amino acid transporter 1
MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNSTTWFQTLIHLLKGN
IGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCAHHFCRRLNKSFVDYGDTV
MYGLESSPCSWLRNHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQVIEAANGTTNNC
HNNETVILTPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIV
QRIPDPSHLPLVAPWKTYPLFFGTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVT
ILYISLGCLGYLQFGANIQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIP
FFVSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLE
VTTFYSEGMSPLTIFKDALISILGFVGFVVGTYEALYELIQPSNAPIFINSTCAFI

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
476

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
53076

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
7.00

# Macromolecular_Interacting_Partner_3_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_3_Specific_Function:
Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_3_Signals:
1-216

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
52-72
79-99
142-162
191-211
216-236
258-278
290-310
343-363
373-393
398-418
440-460

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
31324239

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
S36A1_HUMAN (Q7Z2H8)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC36A1

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC36A1

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:18761

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cell membrane; multi-pass membrane protein. Lysosome; lysosomal membrane; multi-pass membrane protein (By similarity)

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1431 bp
ATGTCCACGCAGAGACTTCGGAATGAAGACTACCACGACTACAGCTCCACGGACGTGAGC
CCTGAGGAGAGCCCGTCGGAAGGCCTCAACAACCTCTCCTCCCCGGGCTCCTACCAGCGC
TTTGGTCAAAGCAATAGCACAACATGGTTCCAGACCTTGATCCACCTGTTAAAAGGCAAC
ATTGGCACAGGACTCCTGGGACTCCCTCTGGCGGTGAAAAATGCAGGCATCGTGATGGGT
CCCATCAGCCTGCTGATCATAGGCATCGTGGCCGTGCACTGCATGGGTATCCTGGTGAAA
TGTGCTCACCACTTCTGCCGCAGGCTGAATAAATCCTTTGTGGATTATGGTGATACTGTG
ATGTATGGACTAGAATCCAGCCCCTGCTCCTGGCTCCGGAACCACGCACACTGGGGAAGA
CGTGTTGTGGACTTCTTCCTGATTGTCACCCAGCTGGGATTCTGCTGTGTCTATTTTGTG
TTTCTGGCTGACAACTTTAAACAGGTGATAGAAGCGGCCAATGGGACCACCAATAACTGC
CACAACAATGAGACGGTGATTCTGACGCCTACCATGGACTCGCGACTCTACATGCTCTCC
TTCCTGCCCTTCCTGGTGCTGCTGGTTTTCATCAGGAACCTCCGAGCCCTGTCCATCTTC
TCCCTGTTGGCCAACATCACCATGCTGGTCAGCTTGGTCATGATCTACCAGTTCATTGTT
CAGAGGATCCCAGACCCCAGCCACCTCCCCTTGGTGGCCCCTTGGAAGACCTACCCTCTC
TTCTTTGGCACAGCGATTTTTTCATTTGAAGGCATTGGAATGGTTCTGCCCCTGGAAAAC
AAAATGAAGGATCCTCGGAAGTTCCCACTCATCCTGTACCTGGGCATGGTCATCGTCACC
ATCCTCTACATCAGCCTGGGGTGTCTGGGGTACCTGCAATTTGGAGCTAATATCCAAGGC
AGCATAACCCTCAACCTGCCCAACTGCTGGTTGTACCAGTCAGTTAAGCTGCTGTACTCC
ATCGGGATCTTTTTCACCTACGCACTCCAGTTCTACGTCCCGGCTGAGATCATCATCCCC
TTCTTTGTGTCCCGAGCGCCCGAGCACTGTGAGTTAGTGGTGGACCTGTTTGTGCGCACA
GTGCTGGTCTGCCTGACATGCATCTTGGCCATCCTCATCCTCCGCCTGGACCTGGTCATC
TCCCTGGTGGGCTCCGTGAGCAGCAGCGCCCTGGCCCTCATCATCCCACCGCTCCTGGAG
GTCACCACCTTCTACTCAGAGGGCATGAGCCCCCTCACCATCTTTAAGGACGCCCTGATC
AGCATCCTGGGCTTCGGGGGCTTTGGGGGGGGGACCTATGAGGCTCTCTATGAGCTGATC
CAGCCAAGCAATGCTCCCATCTTCATCAATTCCACCTGTGCCTTCATATAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF516142

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_3_Locus:
5q33.1

# Macromolecular_Interacting_Partner_3_SNPs:
rs9687945; rs918421; rs6871593; rs12655145; rs7706041; rs723329; rs165370; rs6875844; rs729057; rs4958272; rs4958458; rs1175; rs7730595; rs17112008; rs165323; rs165369; rs6872051; rs17740674; rs11954054; rs10077304; rs14160; rs17802828; rs17717168; rs12654623; rs2278372; rs6868032; rs2278373; rs35060330; rs13362472; rs11950575; rs10074670; rs165353; rs165366; rs357620; rs165364; rs357616; rs2271215; rs152722; rs415426; rs165359; rs357618; rs165350; rs357619; rs165363; rs357628; rs357610; rs165352; rs165367; rs357617; rs7700762; rs165351; rs6892322; rs357627; rs165355; rs7729973; rs357624; rs6579877; rs357614; rs152392; rs7730542; rs357629; rs165365; rs357623; rs357611; rs357613; rs152391; rs357622; rs165357; rs7721225; rs11949709; rs357625; rs17112022; rs7715996; rs173349; rs357608; rs2271217; rs152390; rs152389; rs165358; rs165356; rs6891599; rs441652; rs13165298; rs165361; rs165354; rs7722725; rs151755; rs12109083; rs12108809; rs10476986; rs17112026; rs12652584; rs193299; rs12517705; rs17740853; rs181548; rs357621; rs2278374; rs357609; rs13177627; rs394736; rs165360; rs357630; rs357612; rs189615; rs6884262; rs165324; rs10067717; rs3905908; rs10060512; rs35204299; rs34807130; rs36112231; rs34668619; rs34075182; rs34478431; rs165368; rs35191954; rs1238148; rs3832373; rs34023473; rs1876621; rs33959674; rs6865892; rs35523611; rs13436718; rs10054849; rs1494538; rs36036885; rs10635760; rs10076469; rs35240570; rs35074529; rs33931867; rs5872207; rs35097474; rs7710891; rs11553685; rs34867392; rs400501; rs34306317; rs1494537; rs6868168; rs1644031; rs11435061; rs35256722; rs34814099; rs13155218; rs190360; rs34768974; rs34046389; rs34232698; rs35595732; rs10050844; rs6878589; rs28703169; rs35929969; rs11389317; rs35868592; rs13172953; rs11453209; rs35002039; rs165362; rs28625753; rs6860029; rs13355111; rs34928684; rs35727313; rs34320512; rs36220874; rs5872208; rs1047371; rs33918956; rs357626; rs10067276; rs11750448; rs1654089; rs6878344; rs3841626; rs36024368; rs34013133; rs28591205; rs11949963; rs11167548; rs35707638; rs35655674; rs11303709; rs34145742; rs35361647; rs33938062; rs187180; rs7729206; rs11427460; rs10067553; rs6869796; rs34114557; rs13164973; rs3830456; rs34920684; rs35854261; rs11281205; rs2271216; rs33974809; rs3086279; rs34249564; rs10648851; rs12332278; rs35901406; rs35132795; rs36039116; rs28400419; rs34757222; rs34517564; rs35461038; rs10637454; rs11279332; rs2278375; rs35783925; rs13359993; rs34965236; rs6875491; rs35220703; rs35474478; rs13357451; rs34688075; rs6860591; rs12109979; rs36232311; rs11459545; rs35330119; rs10042192; rs10664114; rs10709981; rs11959634; rs28557209; rs10079386; rs6877865; rs35791981; rs10040628; rs10042791; rs10043854; rs10054626; rs10075373; rs10476771; rs11951808; rs11956563; rs13180182; rs165325; rs165326; rs165327; rs165328; rs165329; rs165330; rs165331; rs165332; rs165333; rs165334; rs165335; rs1654090; rs17111998; rs17717506; rs17802804; rs1876620; rs2545666; rs34831908; rs357607; rs385255; rs393824; rs420486; rs4958457; rs6579878; rs6879238; rs6885230; rs7356707; rs7714380; rs9324696

# Macromolecular_Interacting_Partner_3_General_References:
12809675

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8590

# Macromolecular_Interacting_Partner_4_Name:
Glycine cleavage system H protein, mitochondrial precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
GCSH

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Glycine cleavage system H protein, mitochondrial precursor
MALRVVRSVRALLCTLRAVPLPAAPCPPRPWQLGVGAVRTLRTGPALLSVRKFTEKHEWV
TTENGIGTVGISNFAQEALGDVVYCSLPEVGTKLNKQDEFGALESVKAASELYSPLSGEV
TEINEALAENPGLVNKSCYEDGWLIKMTLSNPSELDELMSEEAYEKYIKSIEE

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
173

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
18911

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
4.56

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
 Function:  Not Available
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
Process:  glycine catabolism
 ||
>>>
 Component:  protein complex
Component:  glycine cleavage complex

# Macromolecular_Interacting_Partner_4_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_4_Specific_Function:
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF01597:GCV_H

# Macromolecular_Interacting_Partner_4_Signals:
1-18

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
184348

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
GCSH_HUMAN (P23434)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
GCSH

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
GCSH

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:4208

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Mitochondrion

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>522 bp
ATGGCGCTGCGAGTGGTGCGGAGCGTGCGGGCCCTGCTCTGCACCCTGCGCGCGGTCCCG
TTACCCGCCGCGCCCTGCCCGCCGAGGCCCTGGCAGCTGGGGGTGGGCGCCGTCCGTACG
CTGCGCACTGGACCCGCTCTGCTCTCGGTGCGTAAATTCACAGAGAAACACGAATGGGTA
ACAACAGAAAATGGCATTGGAACAGTGGGAATCAGCAATTTTGCACAGGAAGCGTTGGGA
GATGTTGTTTATTGTAGTCTCCCTGAAGTTGGGACAAAATTGAACAAACAAGATGAGTTT
GGTGCTTTGGAAAGTGTGAAAGCTGCTAGTGAACTCTATTCTCCTTTATCAGGAGAAGTA
ACTGAAATTAATGAAGCTCTTGCAGAAAATCCAGGACTTGTAAACAAATCTTGTTATGAA
GATGGTTGGCTGATCAAGATGACACTGAGTAACCCTTCAGAACTAGATGAACTTATGAGT
GAAGAAGCATATGAGAAATACATAAAATCTATTGAGGAGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
M69175

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_4_Locus:
16q23.2

# Macromolecular_Interacting_Partner_4_SNPs:
rs8052579; rs8177877; rs8177908; rs8177876; rs8177847; rs8177907; rs8177957; rs8177953; rs1050364; rs8177846; rs5023849; rs8177869; rs8177872; rs7200400; rs4889233; rs8177871; rs8177868; rs7203546; rs8177916; rs874437; rs8177940; rs8177870; rs8177880; rs8177891; rs8043855; rs8177858; rs8047495; rs2316925; rs8177866; rs8177906; rs8177874; rs8177913; rs8177851; rs7185637; rs9922910; rs8177863; rs2316729; rs8177878; rs8177890; rs8177917; rs11866124; rs5023850; rs5023852; rs8177931; rs8177881; rs8177952; rs8177915; rs8177873; rs8177914; rs8177919; rs8177893; rs8052415; rs8063323; rs8177879; rs8177950; rs8177949; rs8177934; rs8177927; rs8177856; rs5023851; rs8177922; rs8177930; rs6420419; rs8177932; rs8177882; rs8177929; rs8177951; rs8177853; rs8177924; rs8177946; rs8177875; rs6564819; rs8177849; rs1563072; rs8177943; rs8177864; rs6420418; rs8177945; rs8177939; rs8177911; rs8177938; rs8177854; rs8177942; rs8177925; rs7187102; rs8177905; rs8177921; rs8177948; rs8177886; rs8177933; rs8177936; rs8177852; rs12444974; rs12598621; rs8177899; rs8177859; rs8177850; rs8177926; rs8177944; rs8177895; rs8048748; rs8177888; rs8177937; rs8048234; rs8177862; rs8177909; rs8177883; rs8177910; rs8177941; rs8177928; rs6420421; rs8177857; rs8177902; rs8177935; rs8177860; rs12445303; rs4324141; rs10514513; rs1414; rs10514514; rs4889232; rs16954582; rs10514512; rs1410; rs1412; rs8177959; rs10514515; rs4306521; rs8177843; rs8177844; rs8177839; rs4324143; rs8059692; rs8177845; rs17849368; rs8177958; rs8177956; rs8177954; rs7186377; rs8052694; rs8177885; rs12924007; rs16954599; rs12922890; rs8177898; rs11476193; rs12921990; rs35161190; rs35385687; rs8177897; rs8177887; rs6420420; rs8177894; rs28472979; rs8177889; rs9932197; rs8177901; rs8177918; rs8177903; rs8177892; rs9926447; rs8177861; rs28709530; rs9933778; rs8177884; rs28586999; rs8177920; rs34270219; rs12923876; rs7196170; rs12928790; rs34446786; rs36052656; rs12928455; rs12922882; rs8177923; rs8177900; rs8177848; rs34324394; rs2316728; rs35682793; rs8177896; rs34391208; rs12928463; rs35209121; rs12923181; rs12924023; rs8177867; rs7203674; rs8177855; rs9923328; rs8177947; rs8177865; rs4888119; rs8177904; rs11150339; rs8177912; rs8050720; rs8177840; rs8177836; rs35887664; rs8177842; rs28672349; rs5818320; rs16954580; rs28613188; rs4324142; rs5818321; rs35387568; rs8177837; rs34910255; rs8177841; rs28391685; rs8177838; rs11859172; rs11859279; rs11862612; rs11863599; rs12444137; rs12932466; rs1563075; rs1563076; rs16954562; rs16954572; rs17763866; rs2045039; rs2316730; rs2317088; rs4889225; rs4889226; rs7185983; rs7206814; rs804904; rs804905; rs8049509; rs8052490; rs8056972; rs935942; rs9923732; rs9925940; rs9925943; rs9929586; rs9933184

# Macromolecular_Interacting_Partner_4_General_References:
1671321; 2025283

# Macromolecular_Interacting_Partner_4_References:
Not Available

# Macromolecular_Interacting_Partner_5_ID:
8594

# Macromolecular_Interacting_Partner_5_Name:
SLC38A2 protein

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
SLC38A2

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>SLC38A2 protein
MKQNLILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIG
AMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGY
TSGLSLLCMVFFLIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDS
CRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYL
LAALFGYLTFYEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTH
LLCASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIK
LVKKEPMKSVQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
406

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
45180

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
8.88

# Macromolecular_Interacting_Partner_5_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_5_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_5_Signals:
1-18

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
5-23; 48-69; 89-111; 115-137; 230-252; 272-294; 315-334; 339-361; 373-395

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
Q6IA88_HUMAN (Q6IA88)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
SLC38A2

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
SLC38A2

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:13448

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
CR457267

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_5_Locus:
12q

# Macromolecular_Interacting_Partner_5_SNPs:
rs10880961; rs7968283; rs956910; rs2897968; rs7968173; rs7961994; rs10880959; rs2307063; rs1873793; rs3742061; rs2307061; rs10880960; rs3782904; rs7965930; rs2307062; rs2279559; rs7974529; rs7960147; rs10785624; rs11183450; rs34139863; rs36065261; rs36022751; rs11340856; rs7966787; rs11313787; rs5797976; rs1046296; rs11183449; rs12307969; rs2307060; rs36019260; rs3837525; rs35534621; rs11183447; rs3832874; rs3830356; rs34489723; rs36066221; rs11298796; rs7295472; rs35732850; rs35944767; rs34099989; rs10880962; rs11183446; rs12368989; rs1492896; rs17096884; rs4768697; rs4768698; rs7135630; rs7967840; rs7975820; rs7979418

# Macromolecular_Interacting_Partner_5_General_References:
Not Available

# Macromolecular_Interacting_Partner_5_References:
Not Available

# Macromolecular_Interacting_Partner_6_ID:
8627

# Macromolecular_Interacting_Partner_6_Name:
4F2 cell-surface antigen heavy chain

# Macromolecular_Interacting_Partner_6_Synonyms:
4F2hc; Lymphocyte activation antigen 4F2 large subunit; 4F2 heavy chain antigen; CD98 antigen

# Macromolecular_Interacting_Partner_6_Gene_Name:
SLC3A2

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>4F2 cellsurface antigen heavy chain
MSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKF
TGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHT
GALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQID
PNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAG
VDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLT
SSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLP
GTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLS
LFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQAS
DLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYAA

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
529

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
57945

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
4.99

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  amylase activity
Function:  alpha-amylase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_6_Specific_Function:
Involved in sodium-independent, high-affinity transport of large neutral amino acids. Required for normal and neoplastic cell growth

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00128:Alpha-amylase

# Macromolecular_Interacting_Partner_6_Signals:
1-98

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
82-104

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
182865

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
4F2_HUMAN (P08195)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SLC3A2

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SLC3A2

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:11026

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1590 bp
ATGAGCCAGGACACCGAGGTGGATATGAAGGAGGTGGAGCTGAATGAGTTAGAGCCCGAG
AAGCAGCCGATGAACGCGGCGTCTGGGGCGGCCATGTCCCTGGCGGGAGCCGAGAAGAAT
GGTCTGGTGAAGATCAAGGTGGCGGAAGACGAGGCGGAGGCGGCAGCCGCGGCTAAGTTC
ACGGGCCTGTCCAAGGAGGAGCTGCTGAAGGTGGCAGGCAGCCCCGGCTGGGTACGCACC
CGCTGGGCACTGCTGCTGCTCTTCTGGCTCGGCTGGCTCGGCATGCTTGCTGGTGCCGTG
GTCATAATCGTGCGAGCGCCGCGTTGTCGCGAGCTACCGGCGCAGAAGTGGTGGCACACG
GGCGCCCTCTACCGCATCGGCGACCTTCAGGCCTTCCAGGGCCACGGCGCGGGCAACCTG
GCGGGTCTGAAGGGGCGTCTCGATTACCTGAGCTCTCTGAAGGTGAAGGGCCTTGTGCTG
GGTCCAATTCACAAGAACCAGAAGGATGATGTCGCTCAGACTGACTTGCTGCAGATCGAC
CCCAATTTTGGCTCCAAGGAAGATTTTGACAGTCTCTTGCAATCGGCTAAAAAAAAGAGC
ATCCGTGTCATTCTGGACCTTACTCCCAACTACCGGGGTGAGAACTCGTGGTTCTCCACT
CAGGTTGACACTGTGGCCACCAAGGTGAAGGATGCTCTGGAGTTTTGGCTGCAAGCTGGC
GTGGATGGGTTCCAGGTTCGGGACATAGAGAATCTGAAGGATGCATCCTCATTCTTGGCT
GAGTGGCAAAATATCACCAAGGGCTTCAGTGAAGACAGGCTCTTGATTGCGGGGACTAAC
TCCTCCGACCTTCAGCAGATCCTGAGCCTACTCGAATCCAACAAAGACTTGCTGTTGACT
AGCTCATACCTGTCTGATTCTGGTTCTACTGGGGAGCATACAAAATCCCTAGTCACACAG
TATTTGAATGCCACTGGCAATCGCTGGTGCAGCTGGAGTTTGTCTCAGGCAAGGCTCCTG
ACTTCCTTCTTGCCGGCTCAACTTCTCCGACTCTACCAGCTGATGCTCTTCACCCTGCCA
GGGACCCCTGTTTTCAGCTACGGGGATGAGATTGGCCTGGATGCAGCTGCCCTTCCTGGA
CAGCCTATGGAGGCTCCAGTCATGCTGTGGGATGAGTCCAGCTTCCCTGACATCCCAGGG
GCTGTAAGTGCCAACATGACTGTGAAGGGCCAGAGTGAAGACCCTGGCTCCCTCCTTTCC
TTGTTCCGGCGGCTGAGTGACCAGCGGAGTAAGGAGCGCTCCCTACTGCATGGGGACTTC
CACGCGTTCTCCGCTGGGCCTGGACTCTTCTCCTATATCCGCCACTGGGACCAGAATGAG
CGTTTTCTGGTAGTGCTTAACTTTGGGGATGTGGGCCTCTCGGCTGGACTGCAGGCCTCC
GACCTGCCTGCCAGCGCCAGCCTCCCAGCCAAGGCTGACCTCCTGCTCAGCACCCAGCCA
GGCCGTGAGGAGGGCTCCCCTCTTGAGCTGGAACGCCTGAAACTGGAGCCTCACGAAGGG
CTGCTGCTCCGCTTCCCCTACGCGGCCTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
J02939

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_6_Locus:
11q13

# Macromolecular_Interacting_Partner_6_SNPs:
rs4726; rs6932; rs489381; rs10897300; rs10897301; rs10792362; rs3809075; rs12221878; rs481235; rs12577251; rs4567465; rs12794763; rs7104190; rs507101; rs7106901; rs12098955; rs561385; rs519473; rs12804553; rs12274689; rs7935096; rs2070870; rs2920155; rs2282477; rs1140538; rs7944051; rs3015957; rs11548759; rs1051342; rs11548756; rs1051289; rs1051290; rs1802910; rs1051237; rs1802911; rs11548760; rs1051285; rs12272749; rs35228448; rs540791; rs549706; rs11231260; rs543622; rs541444; rs34047097; rs35246991; rs1815840; rs3840765; rs11231257; rs544453; rs35881347; rs35320203; rs2957168; rs7130029; rs519425; rs541388; rs34176851; rs535854; rs35091612; rs7106895; rs2096559; rs473815; rs11318751; rs5792273; rs12797676; rs499294; rs34225665; rs3809074; rs2957166; rs7115838; rs12803557; rs521939; rs1938675; rs563394; rs1300138; rs12225962; rs2105515; rs36034735; rs486306; rs12788771; rs1212628; rs1286159; rs5792274; rs12794229; rs7117639; rs495776; rs11231259; rs12366036; rs509327; rs35657900; rs11231261; rs496788; rs35988334; rs12788770; rs34335071; rs1298673; rs766316; rs34722625; rs560603; rs11824602; rs565303; rs34494671; rs35455481; rs7101685; rs1286160; rs510307; rs12270563; rs11231254; rs11231262; rs11318752; rs549635; rs12270604; rs2957167; rs11317361; rs7126772; rs34436839; rs11341257; rs577134; rs11558674; rs1059292; rs11231249; rs11231250; rs12270342; rs12295052; rs1785940; rs2071036; rs2269353; rs2507820; rs2509678; rs2510083; rs3737388; rs3737389; rs4034; rs480730; rs493851; rs498751; rs524891; rs547248; rs560006

# Macromolecular_Interacting_Partner_6_General_References:
3476959; 3036867; 3480538; 3265470; 12754519; 11840567; 12270127

# Macromolecular_Interacting_Partner_6_References:
Not Available

# Macromolecular_Interacting_Partner_7_ID:
8673

# Macromolecular_Interacting_Partner_7_Name:
Sodium-coupled neutral amino acid transporter 4

# Macromolecular_Interacting_Partner_7_Synonyms:
Na(+-coupled neutral amino acid transporter 4; Amino acid transporter A3; System A amino acid transporter 3; System N amino acid transporter 3; Solute carrier family 38 member 4

# Macromolecular_Interacting_Partner_7_Gene_Name:
SLC38A4

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Sodiumcoupled neutral amino acid transporter 4
MDPMELRNVNIEPDDESSSGESAPDSYIGIGNSEKAAMSSQFANEDTESQKFLTNGFLGK
KKLADYADEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSL
YSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEV
IRAFMGLEENTGEWYLNGNYLIIFVSVGIILPLSLLKNLGYLGYTSGFSLTCMVFFVSVV
IYKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLPNNSESSDVNFMMDYTHRNPAGLDEN
QAKGSLHDSGVEYEAHSDDKCEPKYFVFNSRTAYAIPILVFAFVCHPEVLPIYSELKDRS
RRKMQTVSNISITGMLVMYLLAALFGYLTFYGEVEDELLHAYSKVYTLDIPLLMVRLAVL
VAVTLTVPIVLFPIRTSVITLLFPKRPFSWIRHFLIAAVLIALNNVLVILVPTIKYIFGF
IGASSATMLIFILPAVFYLKLVKKETFRSPQKVGALIFLVVGIFFMIGSMALIIIDWIYD
PPNSKHH

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
547

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
60765

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.45

# Macromolecular_Interacting_Partner_7_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_7_Specific_Function:
Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_7_Signals:
1-531

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
81-101
105-125
152-172
196-216
221-241
333-353
370-390
412-432
454-474
477-497
515-535

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
13876616

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
S38A4_HUMAN (Q969I6)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
SLC38A4

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
SLC38A4

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:14679

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Cell membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1644 bp
ATGGATCCCATGGAACTGAGAAATGTCAACATCGAACCAGATGATGAGAGCAGCAGTGGA
GAAAGTGCTCCAGATAGCTACATCGGGATAGGAAATTCAGAAAAGGCAGCAATGAGCAGT
CAATTTGCTAATGAAGACACTGAAAGTCAGAAATTCCTGACAAATGGATTTTTGGGGAAA
AAGAAGCTGGCAGATTATGCTGATGAACACCATCCCGGAACCACTTCCTTTGGAATGTCT
TCATTTAACCTGAGTAATGCCATCATGGGCAGTGGGATCCTGGGCTTGTCCTATGCCATG
GCCAACACAGGGATCATACTTTTTATAATCATGCTGCTTGCTGTGGCAATATTATCACTG
TATTCAGTTCACCTTTTATTAAAAACAGCCAAGGAAGGAGGGTCTTTGATTTATGAAAAA
TTAGGAGAAAAGGCATTTGGATGGCCGGGAAAAATTGGAGCTTTTGTTTCCATTACAATG
CAGAACATTGGAGCAATGTCAAGCTACCTCTTTATCATTAAATATGAACTACCTGAAGTA
ATCAGAGCATTCATGGGACTTGAAGAAAATACTGGAGAATGGTACCTCAATGGCAACTAC
CTCATCATATTTGTGTCTGTTGGAATTATTCTTCCACTTTCGCTCCTTAAAAATTTAGGT
TATCTTGGCTATACCAGTGGATTTTCTCTTACCTGCATGGTGTTTTTTGTTAGTGTGGTG
ATTTACAAGAAATTCCAAATACCCTGCCCTCTACCTGTTTTGGATCACAGTGTTGGAAAT
CTGTCATTCAACAACACGCTTCCAATGCATGTGGTAATGTTACCCAACAACTCTGAGAGT
TCTGATGTGAACTTCATGATGGATTACACCCACCGCAATCCTGCAGGGCTGGATGAGAAC
CAGGCCAAGGGCTCTCTTCATGACAGTGGAGTAGAATATGAAGCTCATAGTGATGACAAG
TGTGAACCCAAATACTTTGTATTCAACTCCCGGACGGCCTATGCAATTCCTATCCTAGTA
TTTGCTTTTGTATGCCACCCTGAGGTCCTTCCCATCTACAGTGAACTTAAAGATCGGTCC
CGGAGAAAAATGCAAACGGTGTCAAATATTTCCATCACGGGGATGCTTGTCATGTACCTG
CTTGCCGCCCTCTTTGGTTACCTAACCTTCTATGGAGAAGTTGAAGATGAATTACTTCAT
GCCTACAGCAAAGTGTATACATTAGACATCCCTCTTCTCATGGTTCGCCTGGCAGTCCTT
GTGGCAGTAACACTAACTGTGCCCATTGTCCTCTTCCCAATTCGTACATCAGTGATCACA
CTGTTATTTCCCAAACGACCCTTCAGCTGGATACGACATTTCCTGATTGCAGCTGTGCTT
ATTGCACTTAATAATGTTCTGGTCATCCTTGTGCCAACTATAAAATACATCTTCGGATTC
ATAGGGGCTTCTTCTGCCACTATGCTGATTTTTATTCTTCCAGCAGTTTTTTATCTTAAA
CTTGTCAAGAAAGAAACTTTTAGGTCACCCCAAAAGGTCGGGGCTTTAATTTTCCTTGTG
GTTGGAATATTCTTCATGATTGGAAGCATGGCACTCATTATAATTGACTGGATTTATGAT
CCTCCAAATTCCAAGCATCACTAA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
AF305814

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_7_Locus:
12q13

# Macromolecular_Interacting_Partner_7_SNPs:
rs2429467; rs11183610; rs180414; rs2465604; rs2429472; rs2250010; rs2191162; rs2715788; rs2465608; rs2430921; rs4627160; rs11183605; rs180438; rs2897981; rs10881001; rs2079787; rs7974413; rs11183618; rs2429470; rs4482114; rs11183617; rs7963399; rs11183616; rs7967842; rs4587804; rs7132006; rs10161209; rs2109125; rs11183619; rs2465605; rs3862137; rs4569081; rs11183620; rs12321267; rs12582305; rs12424453; rs7968752; rs7954772; rs2429473; rs7963807; rs2465586; rs17097332; rs4447249; rs7138295; rs7959916; rs7953215; rs7973308; rs12304394; rs4491335; rs180437; rs12301396; rs10748455; rs2429471; rs12300935; rs4554975; rs12318696; rs10437941; rs7963364; rs10881002; rs7971412; rs7974393; rs12227634; rs17666239; rs12301345; rs11183621; rs17097341; rs10881003; rs180430; rs180431; rs2715779; rs2465585; rs180416; rs2465584; rs180421; rs1860372; rs180408; rs180433; rs180410; rs180409; rs180420; rs180417; rs7297226; rs4768758; rs2287471; rs180427; rs180419; rs2429474; rs4768759; rs2430922; rs2465583; rs6582676; rs180407; rs11183608; rs2465582; rs180434; rs180405; rs11183609; rs180426; rs180435; rs180412; rs2465644; rs12307687; rs180424; rs180429; rs180415; rs17097246; rs2075335; rs12305532; rs180428; rs12316767; rs2287472; rs12581848; rs12307218; rs4768757; rs180425; rs12317419; rs12306007; rs3794308; rs12301214; rs2302855; rs180423; rs180403; rs17097220; rs12313427; rs17602430; rs1860371; rs12826359; rs180422; rs2429465; rs2287473; rs17097286; rs11609184; rs2429466; rs180436; rs180404; rs1468970; rs1468972; rs1468971; rs2465614; rs4340151; rs2430920; rs2465613; rs12315893; rs7489259; rs7976413; rs7962993; rs7965688; rs7976286; rs4262792; rs12309262; rs35448881; rs5797999; rs12426237; rs34557682; rs10523982; rs12824626; rs2543339; rs4537845; rs34666594; rs2429469; rs10161451; rs34886536; rs5798000; rs4575359; rs11558891; rs9804926; rs10693721; rs4388977; rs2430923; rs2429468; rs34878223; rs3764027; rs2465606; rs2465588; rs35064296; rs17097355; rs34251832; rs12308177; rs1072246; rs2465587; rs4335624; rs5798001; rs2907513; rs12819255; rs4768756; rs2532606; rs11370884; rs34540549; rs12298652; rs34594658; rs4623983; rs35779004; rs35709312; rs2429464; rs10691485; rs12832145; rs35826321; rs180413; rs2216433; rs35066357; rs12319423; rs2465616; rs10691484; rs11610757; rs11315253; rs34637197; rs17097192; rs35050099; rs7313706; rs549755; rs36053062; rs11335369; rs3217194; rs11183614; rs12318924; rs4631970; rs34909119; rs12316757; rs180411; rs180432; rs10673975; rs34246069; rs35085914; rs180406; rs34654635; rs34189139; rs11335992; rs4439596; rs416435; rs35774013; rs5797998; rs3958775; rs35668113; rs446993; rs180418; rs34764764; rs34209899; rs11338774; rs10785645; rs11183625; rs11609070; rs11615573; rs12307895; rs12311057; rs12317975; rs12318756; rs12318994; rs12812119; rs17097368; rs17684703; rs2193649; rs2216432; rs2408623; rs2430917; rs2430919; rs2465595; rs2715775; rs2715783; rs4374015; rs4495962; rs4497488; rs4511364; rs4533116; rs4994910; rs7953233; rs7955552; rs7964210; rs7978689; rs7978822; rs7978926

# Macromolecular_Interacting_Partner_7_General_References:
11342143; 11414754

# Macromolecular_Interacting_Partner_7_References:
Not Available

# Macromolecular_Interacting_Partner_8_ID:
8769

# Macromolecular_Interacting_Partner_8_Name:
Sodium- and chloride-dependent glycine transporter 2

# Macromolecular_Interacting_Partner_8_Synonyms:
GlyT2; GlyT-2; Solute carrier family 6 member 5

# Macromolecular_Interacting_Partner_8_Gene_Name:
SLC6A5

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Sodium and chloridedependent glycine transporter 2
MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQ
TFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHC
KIPSLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLGTDGITSVLPGSVATVATQ
EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA
GLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
SFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFT
SQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGK
VVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSA
AWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD
QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRT
HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQR
FCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWL
MLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTS
SLGLKLPVKDLELGTQC

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
797

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
87361

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
7.56

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
 Function:  transporter activity
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_8_Signals:
1-412

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
200-220
228-247
271-291
394-412
421-438
474-491
503-524
557-576
604-622
638-658
679-698
717-735

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
4003525

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
SC6A5_HUMAN (Q9Y345)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
SLC6A5

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
SLC6A5

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:11051

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>2394 bp
ATGGATTGCAGTGCTCCCAAGGAAATGAATAAACTGCCAGCCAACAGCCCGGAGGCGGCG
GCGGCGCAGGGCCACCCGGATGGCCCATGCGCTCCCAGGACGAGCCCGGAGCAGGAGCTT
CCCGCGGCTGCCGCCCCGCCGCCGCCACGTGTGCCCAGGTCCGCTTCCACCGGCGCCCAA
ACTTTCCAGTCAGCGGACGCGCGAGCCTGCGAGGCTGAGCGGCCAGGAGTGGGGTCTTGC
AAACTCAGTAGCCCGCGGGCGCAGGCGGCCTCTGCAGCTCTGCGGGACTTGAGAGAGGCG
CAAGGCGCGCAGGCCTCGCCCCCTCCCGGGAGCTCCGGGCCCGGCAACGCGTTGCACTGT
AAGATCCCTTCTCTGCGAGGCCCGGAGGGGGATGCGAACGTGAGTGTGGGCAAGGGCACC
CTGGAGCGGAACAATACCCCTGTTGTGGGCTGGGTGAACATGAGCCAGAGCACCGTGGTG
CTGGGCACGGATGGAATCACGTCCGTGCTCCCGGGCAGCGTGGCCACCGTTGCCACCCAG
GAGGACGAGCAAGGGGATGAGAATAAGGCCCGAGGGAACTGGTCCAGCAAACTGGACTTC
ATCCTGTCCATGGTGGGGTACGCAGTGGGGCTGGGCAATGTCTGGAGGTTTCCCTACCTG
GCCTTCCAGAACGGGGGAGGTGCTTTCCTCATCCCTTACCTGATGATGCTGGCTCTGGCT
GGATTACCCATCTTCTTCTTGGAGGTGTCGCTGGGCCAGTTTGCCAGCCAGGGACCAGTG
TCTGTGTGGAAGGCCATCCCAGCTCTACAAGGCTGTGGCATCGCGATGCTGATCATCTCT
GTCCTAATAGCCATATACTACAATGTGATTATTTGCTATACACTTTTCTACCTGTTTGCC
TCCTTTGTGTCTGTACTACCCTGGGGCTCCTGCAACAACCCTTGGAATACACCAGAATGC
AAAGATAAAACCAAACTTTTATTAGATTCCTGTGTTATCAGTGACCATCCCAAAATACAG
ATCAAGAACTCGACTTTCTGCATGACCGCTTATCCCAACGTGACAATGGTTAATTTCACC
AGCCAGGCCAATAAGACATTTGTCAGTGGAAGTGAAGAGTACTTCAAGTACTTTGTGCTG
AAGATTTCTGCAGGGATTGAATATCCTGGCGAGATCAGGTGGCCACTAGCTCTCTGCCTC
TTCCTGGCTTGGGTCATTGTGTATGCATCGTTGGCTAAAGGAATCAAGACTTCAGGAAAA
GTGGTGTACTTCACGGCCACGTTCCCGTATGTCGTACTCGTGATCCTCCTCATCCGAGGA
GTCACCCTGCCTGGAGCTGGAGCTGGGATCTGGTACTTCATCACACCCAAGTGGGAGAAA
CTCACGGATGCCACGGTGTGGAAAGATGCTGCCACTCAGATTTTCTTCTCTTTATCTGCT
GCATGGGGAGGCCTGATCACTCTCTCTTCTTACAACAAATTCCACAACAACTGCTACAGG
GACACTCTAATTGTCACCTGCACCAACAGTGCCACAAGCATCTTTGCCGGCTTCGTCATC
TTCTCCGTTATCGGCTTCATGGCCAATGAACGCAAAGTCAACATTGAGAATGTGGCAGAC
CAAGGGCCAGGCATTGCATTTGTGGTTTACCCGGAAGCCTTAACCAGGCTGCCTCTCTCT
CCGTTCTGGGCCATCATCTTTTTCCTGATGCTCCTCACTCTTGGACTTGACACTATGTTT
GCCACCATCGAGACCATAGTGACCTCCATCTCAGACGAGTTTCCCAAGTACCTACGCACA
CACAAGCCAGTGTTTACTCTGGGCTGCTGCATTTGTTTCTTCATCATGGGTTTTCCAATG
ATCACTCAGGGTGGAATTTACATGTTTCAGCTTGTGGACACCTATGCTGCCTCCTATGCC
CTTGTCATCATTGCCATTTTTGAGCTCGTGGGGATCTCTTATGTGTATGGCTTGCAAAGA
TTCTGTGAAGATATAGAGATGATGATTGGATTCCAGCCTAACATCTTCTGGAAAGTCTGC
TGGGCATTTGTAACCCCAACCATTTTAACCTTTATCCTTTGCTTCAGCTTTTACCAGTGG
GAGCCCATGACCTATGGCTCTTACCGCTATCCTAACTGGTCCATGGTGCTCGGATGGCTA
ATGCTCGCCTGTTCCGTCATCTGGATCCCAATTATGTTTGTGATAAAAATGCATCTGGCC
CCTGGAAGATTTATTGAGAGGCTGAAGTTGGTGTGCTCGCCACAGCCGGACTGGGGCCCA
TTCTTAGCTCAACACCGCGGGGAGCGTTACAAGAACATGATCGACCCCTTGGGAACCTCT
TCCTTGGGACTCAAACTGCCAGTGAAGGATTTGGAACTGGGCACTCAGTGCTAG

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
AF085412

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_8_Locus:
11p15.2-p15.1

# Macromolecular_Interacting_Partner_8_SNPs:
rs1443548; rs16906628; rs7944684; rs3740870; rs1805091; rs1443547; rs34243519; rs2276433; rs2241941; rs7109418; rs1443551; rs1401793; rs2241939; rs10741849; rs4923387; rs4923386; rs4923392; rs7942096; rs7950354; rs1373165; rs2298824; rs10766703; rs1945779; rs2001982; rs2241940; rs2403605; rs7119457; rs3819252; rs3758807; rs883377; rs7942430; rs867540; rs4923496; rs2298826; rs4922780; rs10766706; rs4922798; rs10766708; rs2276430; rs3740872; rs3781740; rs874680; rs4454712; rs10766705; rs3740873; rs2276431; rs10741847; rs1945778; rs4922794; rs4923548; rs1715257; rs1894163; rs10766710; rs7130558; rs1945774; rs4922790; rs10833371; rs10741848; rs1617769; rs11025670; rs10833366; rs4923480; rs11604555; rs11025663; rs7925624; rs4923409; rs894749; rs10833367; rs11025671; rs1401786; rs11025662; rs7942801; rs4922792; rs2896606; rs874679; rs4923389; rs10500882; rs11025673; rs16906566; rs2000959; rs3758808; rs16906552; rs16906549; rs894750; rs2241942; rs1838177; rs4923476; rs11025652; rs6483713; rs1945773; rs1945771; rs11025660; rs4423178; rs10833370; rs11025664; rs11025646; rs10833364; rs10833369; rs4923345; rs11827415; rs7110148; rs2276429; rs11025659; rs3781735; rs4922795; rs16906547; rs17298481; rs11025661; rs11025665; rs17298474; rs7115429; rs4477436; rs7106526; rs16906539; rs2276432; rs16906564; rs10833363; rs6483712; rs7112587; rs2298825; rs3781742; rs2298829; rs11025658; rs7950131; rs12284342; rs10741852; rs12420100; rs2278649; rs11605104; rs1792974; rs16906550; rs11025672; rs11601505; rs11025654; rs7948119; rs3781744; rs7934790; rs12226489; rs7925072; rs7111588; rs11025650; rs7111667; rs11025657; rs12416864; rs3781743; rs3898548; rs4923627; rs12288053; rs7128571; rs3781748; rs874681; rs11025645; rs1348401; rs1894162; rs12283302; rs10833368; rs12362564; rs12419577; rs11025648; rs1107420; rs11025678; rs11605055; rs11025651; rs7950453; rs12222012; rs10833372; rs3781746; rs7127127; rs11605703; rs11025674; rs12803296; rs881445; rs10766707; rs12363968; rs4923462; rs7936680; rs12273627; rs7940151; rs11600101; rs7128875; rs11025669; rs7924947; rs11025653; rs2289683; rs7929586; rs4923602; rs7104406; rs7950132; rs17298460; rs4923601; rs2298828; rs12576068; rs11025644; rs11827481; rs1715297; rs12364685; rs1443549; rs11025666; rs7925597; rs34505618; rs2586710; rs7952227; rs1573562; rs894748; rs35569835; rs12283304; rs34960315; rs1792977; rs1519739; rs11025647; rs10597763; rs11370466; rs4923479; rs4922785; rs2586713; rs35903152; rs12798953; rs12288112; rs33956432; rs11025675; rs35126756; rs3045384; rs12793854; rs7130682; rs3781738; rs4244550; rs35784570; rs12420791; rs12800775; rs4923582; rs11823699; rs1792989; rs35109452; rs11605017; rs10741851; rs1894161; rs7123437; rs34561522; rs36212129; rs12420384; rs12225513; rs2586711; rs10531757; rs12285915; rs11025676; rs1573563; rs7123182; rs10766709; rs35387988; rs12802662; rs1945780; rs11600795; rs12804634; rs11025677; rs4923426; rs34930568; rs5790133; rs11025668; rs34536559; rs12793841; rs34853326; rs35697819; rs12805090; rs7115052; rs11605050; rs2586712; rs2853013; rs11362929; rs4317982; rs34259678; rs10741846; rs2853014; rs34884629; rs12294898; rs10549594; rs10741850; rs7115488; rs1792975; rs12802680; rs12795318; rs1715296; rs3045403; rs34600715; rs2105804; rs2015556; rs35152433; rs10623159; rs4922791; rs11025655; rs12270626; rs1715295; rs34340008; rs35755752; rs2853018; rs34426842; rs34797396; rs1519741; rs11025656; rs35435495; rs34785948; rs11314244; rs2298827; rs5790132; rs35407586; rs2586714; rs1945767; rs34688564; rs34773830; rs35751270; rs34348153; rs7128375; rs3045404; rs3781739; rs10695726; rs35139424; rs35125827; rs34211639; rs881444; rs1443550; rs11294668; rs4488192; rs34284603; rs11382540; rs10591486; rs11364911; rs4617577; rs12573946; rs35031994; rs7130611; rs35696142; rs12363838; rs12286319; rs11604979; rs3781745; rs28477645; rs12293253; rs34437718; rs4923606; rs1519745; rs3837390; rs10680098; rs10579245; rs11383281; rs10766704; rs5790131; rs35256884; rs34062243; rs7123680; rs7126902; rs34248858; rs10466424; rs10766701; rs10766702; rs11025642; rs11025643; rs12788792; rs12789398; rs12791734; rs1519740; rs1624836; rs1626567; rs16906495; rs16906499; rs16906507; rs16906511; rs1715285; rs1715286; rs1715298; rs1715299; rs17232722; rs1792961; rs1792962; rs1792964; rs1792965; rs1792967; rs1792968; rs2139424; rs2586709; rs3802804; rs3993128; rs4537751; rs4922574; rs4923219; rs4923220; rs7122910; rs7127159; rs7131598; rs7945388; rs894747; rs953115; rs968695; rs968696

# Macromolecular_Interacting_Partner_8_General_References:
9845349; 10381548; 10606742

# Macromolecular_Interacting_Partner_8_References:
Not Available

# Macromolecular_Interacting_Partner_9_ID:
8881

# Macromolecular_Interacting_Partner_9_Name:
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

# Macromolecular_Interacting_Partner_9_Synonyms:
Amino acid transporter ATB0+; Solute carrier family 6 member 14

# Macromolecular_Interacting_Partner_9_Gene_Name:
SLC6A14

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Sodium and chloridedependent neutral and basic amino acid transporter B0+
MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVW
RFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGIT
MVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNK
GIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLA
LCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQ
SNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVF
AGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLG
LDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHF
CAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAI
FIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCC
RPASNWGPYLEQHRGERYKDMVDPKKEADHEIPTVSGSRKPE

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
642

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
72154

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
8.27

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
 Function:  transporter activity
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_9_Signals:
1-469

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
45-65
72-92
110-130
235-255
261-281
315-335
348-368
399-419
450-477
480-500
528-548
563-583

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
5732680

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
S6A14_HUMAN (Q9UN76)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
SLC6A14

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
SLC6A14

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:11047

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>1929 bp
ATGGACAAGTTGAAATGCCCGAGTTTCTTCAAGTGCAGGGAGAAGGAGAAAGTGTCGGCT
TCATCAGAGAATTTCCATGTTGGTGAAAATGATGAGAATCAGGACCGTGGTAACTGGTCC
AAAAAATCGGATTATCTTCTATCTATGATTGGATACGCAGTGGGATTAGGAAATGTGTGG
AGATTTCCATATCTGACCTACAGCAATGGTGGAGGCGCCTTCTTGATACCTTATGCAATT
ATGTTAGCATTGGCTGGTTTACCTTTGTTCTTTCTGGAGTGTTCACTGGGACAATTTGCT
AGCTTAGGTCCAGTTTCAGTTTGGAGGATTCTTCCATTGTTTCAAGGTGTGGGAATTACA
ATGGTCCTGATCTCCATTTTTGTGACAATCTATTACAATGTCATAATTGCCTATAGTCTT
TACTACATGTTTGCTTCTTTTCAAAGTGAACTACCATGGAAAAATTGTTCTTCGTGGTCA
GATAAAAACTGTAGCAGATCACCAATAGTAACTCACTGTAATGTGAGTACAGTGAATAAA
GGAATACAAGAGATCATCCAAATGAATAAAAGCTGGGTAGACATCAACAATTTTACCTGC
ATCAACGGCAGTGAAATTTATCAGCCAGGGCAGCTTCCCAGTGAACAATATTGGAATAAA
GTGGCGCTCCAACGGTCAAGTGGAATGAATGAGACTGGAGTAATTGTTTGGTATTTAGCA
CTTTGTCTTCTTCTGGCTTGGCTCATAGTTGGAGCAGCACTATTTAAAGGAATCAAATCG
TCTGGCAAGGTGGTATATTTTACAGCTCTTTTCCCCTATGTGGTCCTACTCATCCTGTTA
GTACGAGGTGCAACTCTGGAGGGTGCTTCAAAAGGCATTTCATACTATATTGGAGCCCAG
TCAAATTTTACAAAACTTAAGGAAGCTGAGGTATGGAAAGATGCTGCCACTCAGATATTT
TACTCCCTTTCAGTGGCTTGGGGTGGCTTAGTTGCTCTATCATCTTACAATAAGTTCAAA
AACAACTGCTTCTCTGATGCCATTGTGGTTTGTTTGACAAACTGTCTCACTAGCGTGTTT
GCTGGATTTGCTATTTTTTCTATATTGGGACACATGGCCCATATATCTGGAAAGGAAGTT
TCTCAAGTTGTAAAATCAGGTTTTGATTTGGCATTCATTGCCTATCCAGAGGCTCTAGCC
CAACTCCCAGGTGGTCCATTTTGGTCCATATTATTTTTTTTCATGCTTTTAACTTTGGGT
CTCGATTCTCAGTTTGCTTCGATTGAAACGATCACAACAACAATTCAAGATTTATTTCCC
AAAGTGATGAAGAAAATGAGGGTTCCCATAACTTTGGGCTGCTGCTTGGTTTTGTTTCTC
CTTGGTCTCGTCTGTGTGACTCAGGCTGGAATTTACTGGGTTCATCTGATTGACCACTTC
TGTGCTGGATGGGGCATTTTAATTGCAGCTATACTGGAGCTAGTTGGAATCATCTGGATT
TATGGAGGGAACAGATTCATTGAGGATACAGAAATGATGATTGGAGCAAAGAGGTGGATA
TTCTGGCTATGGTGGAGAGCTTGCTGGTTTGTAATTACGCCTATCCTTTTGATTGCAATA
TTTATCTGGTCATTGGTGCAATTTCATAGACCTAATTATGGCGCAATTCCATACCCTGAC
TGGGGAGTTGCTTTAGGCTGGTGTATGATTGTTTTCTGCATTATTTGGATACCAATTATG
GCTATCATAAAAATAATTCAGGCTAAAGGAAACATCTTTCAACGCCTTATAAGTTGCTGC
AGACCAGCTTCTAACTGGGGTCCATACCTGGAACAACATCGTGGGGAAAGATATAAAGAC
ATGGTAGATCCTAAAAAAGAGGCTGACCATGAAATACCTACTGTTAGTGGCAGCAGAAAA
CCGGAATGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
AF151978

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_9_Locus:
Xq23-q24

# Macromolecular_Interacting_Partner_9_SNPs:
rs12720074; rs2011162; rs5905179; rs12710570; rs5905289; rs2011198; rs2312055; rs2032525; rs5905176; rs5905284; rs7059155; rs2071877; rs4824325; rs10217924; rs5905178; rs6608646; rs12392462; rs2312057; rs12391221; rs17242824; rs5905288; rs12559530; rs10218102; rs10521579; rs12710569; rs10521578; rs5905285; rs5952101; rs12720080; rs12720088; rs5952099; rs12720083; rs5905177; rs4824358; rs4824324; rs12720076; rs4824359; rs12720084; rs12720079; rs5952103; rs2312056; rs12720089; rs17095419; rs12393509; rs4824323; rs2312054; rs7052454; rs12710568; rs12720073; rs12834312; rs3788766; rs5905283; rs12720085; rs28523889; rs6608648; rs11350870; rs34685017; rs28699570; rs12720092; rs28628632; rs12720078; rs5952174; rs35604008; rs5952104; rs5905287; rs6608645; rs12388847; rs10629819; rs12720087; rs12720091; rs35269408; rs17308739; rs3043424; rs35542990; rs5952100; rs5952102; rs35201069; rs6651554; rs12720077; rs10218234; rs6608647; rs12858125; rs34117081; rs5952175; rs12720082; rs34490652; rs4068397; rs7066547; rs7054956; rs12832551; rs10218418; rs12720075; rs12720086; rs12720090; rs35315031; rs7062559; rs10218017; rs12390279; rs12833869; rs12835480; rs12839137; rs12844003; rs17308697; rs2103697; rs2301451; rs5952181; rs6520234; rs6608511; rs6608514; rs6608644; rs6608650

# Macromolecular_Interacting_Partner_9_General_References:
10446133

# Macromolecular_Interacting_Partner_9_References:
Not Available

# Macromolecular_Interacting_Partner_10_ID:
8896

# Macromolecular_Interacting_Partner_10_Name:
Vesicular inhibitory amino acid transporter

# Macromolecular_Interacting_Partner_10_Synonyms:
GABA and glycine transporter; Vesicular GABA transporter; hVIAAT; Solute carrier family 32 member 1

# Macromolecular_Interacting_Partner_10_Gene_Name:
SLC32A1

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Vesicular inhibitory amino acid transporter
MATLLRSKLSNVATSVSNKSQAKMSGMFARMGFQAATDEEAVGFAHCDDLDFEHRQGLQM
DILKAEGEPCGDEGAEAPVEGDIHYQRGSGAPLPPSGSKDQVGGGGEFGGHDKPKITAWE
AGWNVTNAIQGMFVLGLPYAILHGGYLGLFLIIFAAVVCCYTGKILIACLYEENEDGEVV
RVRDSYVAIANACCAPRFPTLGGRVVNVAQIIELVMTCILYVVVSGNLMYNSFPGLPVSQ
KSWSIIATAVLLPCAFLKNLKAVSKFSLLCTLAHFVINILVIAYCLSRARDWAWEKVKFY
IDVKKFPISIGIIVFSYTSQIFLPSLEGNMQQPSEFHCMMNWTHIAACVLKGLFALVAYL
TWADETKEVITDNLPGSIRAVVNIFLVAKALLSYPLPFFAAVEVLEKSLFQEGSRAFFPA
CYSGDGRLKSWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRL
LWRKLLWHQVFFDVAIFVIGGICSVSGFVHSLEGLIEAYRTNAED

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
525

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
57416

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
6.63

# Macromolecular_Interacting_Partner_10_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_10_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_10_Specific_Function:
Involved in the uptake of GABA and glycine into the synaptic vesicles

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_10_Signals:
Not Available

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
134-154
205-225
243-263
266-286
306-326
342-362
384-404
439-459
462-482
490-510

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
17975777

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
VIAAT_HUMAN (Q9H598)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
SLC32A1

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
SLC32A1

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:11018

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Cytoplasmic vesicle; cytoplasmic vesicle membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>1578 bp
ATGGCCACCTTGCTCCGCAGCAAGCTGTCCAACGTGGCCACGTCCGTGTCCAACAAGTCC
CAGGCCAAGATGAGCGGCATGTTCGCCAGGATGGGTTTTCAGGCGGCCACGGATGAGGAG
GCGGTGGGCTTCGCGCATTGCGACGACCTCGACTTTGAGCACCGCCAGGGCCTGCAGATG
GACATCCTGAAAGCCGAGGGAGAGCCCTGCGGGGACGAGGGCGCTGAAGCGCCCGTCGAG
GGAGACATCCATTATCAGCGAGGCAGCGGAGCTCCTCTGCCGCCCTCCGGCTCCAAGGAC
CAGGTGGGAGGTGGTGGCGAATTCGGGGGCCACGACAAGCCCAAAATCACGGCGTGGGAG
GCAGGCTGGAACGTGACCAACGCCATCCAGGGCATGTTCGTGCTGGGCCTACCCTACGCC
ATCCTGCACGGCGGCTACCTGGGGTTGTTTCTCATCATCTTCGCCGCCGTTGTGTGCTGC
TACACCGGCAAGATCCTCATCGCGTGCCTGTACGAGGAGAATGAAGACGGCGAGGTGGTG
CGCGTGCGGGACTCGTACGTGGCCATAGCCAACGCCTGCTGCGCCCCGCGCTTCCCAACG
CTGGGCGGCCGAGTGGTGAACGTAGCGCAGATCATCGAGCTGGTGATGACGTGCATCCTG
TACGTGGTGGTGAGTGGCAACCTCATGTACAACAGCTTCCCGGGGCTGCCCGTGTCGCAG
AAGTCCTGGTCCATTATCGCCACGGCCGTGCTGCTGCCTTGCGCCTTCCTTAAGAACCTC
AAGGCCGTGTCCAAGTTCAGTCTGCTGTGCACTCTGGCCCACTTCGTCATCAATATCCTG
GTCATAGCCTACTGTCTATCGCGGGCGCGCGACTGGGCCTGGGAGAAGGTCAAGTTCTAC
ATCGACGTCAAGAAGTTCCCCATCTCCATTGGCATCATCGTGTTCAGCTACACGTCTCAG
ATCTTCCTGCCTTCGCTGGAGGGCAATATGCAGCAGCCCAGCGAGTTCCACTGCATGATG
AACTGGACGCACATCGCAGCCTGCGTGCTCAAGGGCCTCTTCGCGCTCGTCGCCTACCTC
ACCTGGGCCGACGAGACCAAGGAGGTCATCACGGATAACCTGCCCGGCTCCATCCGCGCC
GTGGTCAACATCTTTCTGGTGGCCAAGGCGCTGTTGTCCTATCCTCTGCCATTCTTTGCC
GCTGTCGAGGTGCTGGAGAAGTCGCTCTTCCAGGAAGGCAGCCGCGCCTTTTTCCCGGCC
TGCTACAGCGGCGACGGGCGCCTGAAGTCCTGGGGGCTGACGCTGCGCTGCGCGCTCGTC
GTCTTCACGCTGCTCATGGCCATTTATGTGCCGCACTTCGCGCTGCTCATGGGCCTCACC
GGCAGCCTCACGGGCGCCGGCCTCTGTTTCTTGCTGCCCAGCCTCTTTCACCTGCGCCTG
CTCTGGCGCAAGCTGCTGTGGCACCAAGTCTTCTTCGACGTCGCCATCTTCGTCATCGGC
GGCATCTGCAGCGTGTCCGGCTTCGTGCACTCCCTCGAGGGCCTCATCGAAGCCTACCGA
ACCAACGCGGAGGACTAG

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
AY044836

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_10_Locus:
20q11.23

# Macromolecular_Interacting_Partner_10_SNPs:
rs34517228; rs16987520; rs16987519; rs6128821; rs6128822; rs8118790; rs6064926; rs4328688; rs6100927; rs6100928; rs6100926; rs2865; rs41304659; rs6100930; rs6027611; rs6027610; rs34068158; rs41311047; rs41305815; rs11477723; rs6027609; rs2867326; rs8125102; rs6071200; rs13042447; rs1010321; rs11700227; rs11906418; rs12624979; rs1321099; rs1322183; rs1406857; rs1406858; rs16987521; rs16987523; rs2180224; rs2246443; rs2246672; rs2246804; rs2247054; rs2263747; rs2757515; rs6027580; rs6064941; rs6071237; rs6092933; rs6092935; rs6092955; rs6100937; rs6100962; rs6128836; rs7274633; rs733549; rs911717; rs911718; rs911719; rs997848; rs998277

# Macromolecular_Interacting_Partner_10_General_References:
12031963; 11780052; 12115694

# Macromolecular_Interacting_Partner_10_References:
Not Available

End of HMDB00123

Beginning of HMDB00124
# Accession_No:
HMDB00124

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-09-11 08:18:05

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Fructose 6-phosphate

# Description:
An important intermediate in the Carbohydrates pathway. The interconversion of glucose-6-phosphate and fructose-6-phosphate, the second step of the Embden-Meyerhof glycolytic pathway, is catalyzed by the enzyme phosphoglucose isomerase (PGI). In gluconeogenesis, fructose-6-phosphate is the immediate precursor of glucose-6-phosphate (wikipedia)

# Synonyms:
D-Fructose 6-phosphate; D-Fructose 6-phosphorate; D-Fructose 6-phosphoric acid; D-fructose-6-P; D-fructose-6-phosphate; FPC; Fructose 6-phosphate; Fructose 6-phosphic acid; Fructose-6-phosphate; Neuberg ester; fru-6-P; fructose-6-P; fructose-6P

# Chemical_IUPAC_Name:
[(2R,3R,4S)-2,3,4,6-tetrahydroxy-5-oxo-hexoxy]phosphonic acid

# Chemical_Formula:
C6H13O9P

# Chemical_Structure:
tbl_chemical:::HMDB00124_ZOOM.png:::119283202703628589

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00124_THUMB.png:::119283202508341452

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Sugars; Sugar Phosphates

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
ketone; primary alcohol; secondary alcohol; 1,2-diol; phosphoric acid ester

# Taxonomy_Biofunction:
Component of Aminosugars metabolism; Component of Fructose and mannose metabolism; Component of Galactose metabolism; Component of Glutamate metabolism; Component of Starch and sucrose metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
260.02972

# Molecular_Weight_Avg:
260.13577

# Smiles_String_isomeric:
OCC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O

# Smiles_String_canonical:
OCC(=O)C(O)C(O)C(O)COP(O)(O)=O

# KEGG_Compound_ID:
C00085

# BioCyc_ID:
FRUCTOSE-6P

# PubChem_CID:
69507

# PubChem_SID:
8192994; 211681; 7887397; 691766; 7887546; 585657; 855114; 841537; 8145072

# OMIM_ID:
232800; 602579

# Metagene_ID:
Not Available

# BiGG_ID:
33795

# Wikipedia_ID:
Fructose 6-phosphate

# METLIN_ID:
5159

# Ref_ID:
1332571; 16077128; 15925468; 15882454; 16055050; 3777162; 2346009; 9451038; 15033269

# ChEBI_ID:
15946

# CAS_Registry_Number:
643-13-0

# InChI:
InChI=1/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h4-7,9-11H,1-2H2,(H2,12,13,14)/t4-,5-,6-/m1/s1

# Synthesis_Reference:
Not Available

# Melting_Point:
Not Available

# Melting_Point_predicted:
109.7 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
911 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
1000.0 mg/mL [MEYLAN,WM et al. (1996)]; 23.2 mg/mL [Predicted by ALOGPS]

# phys_charge:
-2

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-1.86 [Predicted by ALOGPS]; -5.1 [Predicted by PubChem via XLOGP]; -2.14 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Fructose-6-phosphate.mol:::113272380840649574

# SDF_File_[Text]:
tbl_chemical:::HMDB00124.sdf:::119283202105836892

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00124.pdb:::119283202373429529

# PDB_ID:
1CNQ

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041201_P06_46_BA_1DP_presat.zip:::11462515484067425

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:


# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041201_P06_46_BA_1DP_presat.png:::11479028145276339

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041201_P06_46_BA_1DP_presat_1.zip:::114721309595655613

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041201_P06_46_BA_2DHSQC_984.png:::114807717251728362

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041201_P06_46_BA_2DHSQC_984.zip:::11480771725308940

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041201_P06_46_BA_2DHSQC_984_Assigned.png:::116250836090469668

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Fructose-6-phosphate.gif:::113273211121830015

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00124_peaks.txt:::1156309559627638774

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Fructose-6-phosphate_C.gif:::1132737691346114238

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00124_peaks.txt:::1156310749701808353

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00124L.png:::11755526687062128; Medium Energy:tbl_ms:::HMDB00124M.png:::117555270717656924; High Energy:tbl_ms:::HMDB00124H.png:::117555272690967282

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000012.png:::116890822195336121

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000012.txt:::116890822195347152

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000012.png:::116890822167185699

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000012.txt:::11689082219534741

# Cellular_Location:
Cytoplasm (Predicted from LogP)

# Tissue_Location:
Intestine

# deuterated:
No

# Biofluid_Location:
Bile; Blood; Cellular Cytoplasm

# Concentration_[Normal]:
Blood	12.0	uM	N/A	Both	Normal	16055050
Blood	9.9 +/- 2.3	uM	Newborn:0-30_days_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	10.2 +/- 1.8	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Cellular_Cytoplasm	16.0 (13.0-19.0)	umol/L	Adult:>18_yrs_old	Both	Normal	15882454
Cellular_Cytoplasm	49.6	uM	Adult:>18_yrs_old	Both	Normal	15925468


# Concentration_[Abnormal]:
Blood	6.9 (4.86 - 9.01)	uM	Adult:>18_yrs_old	Both	Transketolase and transaldolase (TALDO) deficiency	16055050


# Associated_Disorders:
Transketolase and transaldolase (TALDO) deficiency

# Pathway_Names:
Galactose metabolism;N-Glycan biosynthesis;Starch and sucrose metabolism;Glycolysis;Fructose and mannose metabolism;Streptomycin biosynthesis;Aminosugars metabolism;Glycerolipid metabolism;Glycosphingolipid metabolism;Keratan sulfate biosynthesis

# Pathway_Images:
;;;Glycolysis.jpg;fructose_metabolism.jpg;;;;;

# KEGG_Images:
map00052;map00510;map00500;map00010;map00051;map00521;map00530;map00561;map00600;map00533

# Pathway_Graphs:
;;;Glycolysis_Graph.jpg;fructose_metabolism_Graph.jpg;;;;;

# Pathway_SBMLs:
;;;Glycolysis.xml;fructose_metabolism.xml;;;;;

# Metabolic_Enzyme_1_ID:
5601

# Metabolic_Enzyme_1_Name:
Lactase-phlorizin hydrolase precursor

# Metabolic_Enzyme_1_Synonyms:
Lactase-glycosylceramidase[Includes: Lactase

# Metabolic_Enzyme_1_Gene_Name:
LCT

# Metabolic_Enzyme_1_Protein_Sequence:
>Lactasephlorizin hydrolase precursor
MELSWHVVFIALLSFSCWGSDWESDRNFISTAGPLTNDLLHNLSGLLGDQSSNFVAGDKD
MYVCHQPLPTFLPEYFSSLHASQITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKAL
KTARLQPMVILHHQTLPASTLRRTEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIK
ELPHQESRASQLQTLSDAHRKAYEIYHESYAFQGGKLSVVLRAEDIPELLLEPPISALAQ
DTVDFLSLDLSYECQNEASLRQKLSKLQTIEPKVKVFIFNLKLPDCPSTMKNPASLLFSL
FEAINKDQVLTIGFDINEFLSCSSSSKKSMSCSLTGSLALQPDQQQDHETTDSSPASAYQ
RVWEAFANQSRAERDAFLQDTFPEGFLWGASTGAFNVEGGWAEGGRGVSIWDPRRPLNTT
EGQATLEVASDSYHKVASDVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKL
IDRLQDAGIEPMATLFHWDLPQALQDHGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTF
HEPWVMSYAGYGTGQHPPGISDPGVASFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIV
LNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFVDGDYPATLRTQIQQMNRQCSHPV
AQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQHVNHVWPQT
SSSWIRVVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYIN
EVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTS
IIEKNGFLTKGAKRLLPPNTVNLPSKVRAFTFPSEVPSKAKVVWEKFSSQPKFERDLFYH
GTFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLD
ADLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFH
WDLPQALQDIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFP
PGVKDPGWAPYRIAHTVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDV
EAADRMLQFSLGWFAHPIFRNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRAT
ADVFCLNTYYSRIVQHKTPRLNPPSYEDDQEMAEEEDPSWPSTAMNRAAPWGTRRLLNWI
KEEYGDIPIYITENGVGLTNPNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWSLMD
NFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMPLAREDEFLYGRFPEG
FIWSAASAAYQIEGAWRADGKGLSIWDTFSHTPLRVENDAIGDVACDSYHKIAEDLVTLQ
NLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHWDLPQTL
QDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTAAPGVSNRP
GTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSNQEDVEAARRY
VQFMGGWFAHPIFKNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRINGTYDFFGF
NHYTTVLAYNLNYATAISSFDADRGVASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEY
NDPPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEW
ATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPDPATGPHACLHQPDAGPTI
SPVRQEEVQFLGLMLGTTEAQTALYVLFSLVLLGVCGLAFLSYKYCKRSKQGKTQRSQQE
LSPVSSF

# Metabolic_Enzyme_1_Number_of_Residues:
1927

# Metabolic_Enzyme_1_Molecular_Weight:
218604

# Metabolic_Enzyme_1_Theoretical_pI:
6.30

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  glucosidase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
LPH splits lactose in the small intestine

# Metabolic_Enzyme_1_Pathway:
map00052  Galactose metabolism

# Metabolic_Enzyme_1_Reaction:
lactose + H2O = D-galactose + D-glucose

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00232:Glyco_hydro_1

# Metabolic_Enzyme_1_Signals:
1-19

# Metabolic_Enzyme_1_Transmembrane_Regions:
1883-1901

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.2.1.108;EC 3.2.1.62

# Metabolic_Enzyme_1_GenBank_ID_Protein:
34400

# Metabolic_Enzyme_1_SwissProt_ID:
LPH_HUMAN (P09848)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
LCT

# Metabolic_Enzyme_1_Geneatlas_id:
LCT

# Metabolic_Enzyme_1_hgnc_id:
HGNC:6530

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cell membrane; apical cell membrane; single- pass type I membrane protein. Note=Brush border

# Metabolic_Enzyme_1_Gene_Sequence:
>5784 bp
ATGGAGCTGTCTTGGCATGTAGTCTTTATTGCCCTGCTAAGTTTTTCATGCTGGGGGTCA
GACTGGGAGTCTGATAGAAATTTCATTTCCACCGCTGGTCCTCTAACCAATGACTTGCTG
CACAACCTGAGTGGTCTCCTGGGAGACCAGAGTTCTAACTTTGTAGCAGGGGACAAAGAC
ATGTATGTTTGTCACCAGCCACTGCCCACTTTCCTGCCAGAATACTTCAGCAGTCTCCAT
GCCAGTCAGATCACCCATTATAAGGTATTTCTGTCATGGGCACAGCTCCTCCCAGCAGGA
AGCACCCAGAATCCAGACGAGAAAACAGTGCAGTGCTACCGGCGACTCCTCAAGGCCCTC
AAGACTGCACGGCTTCAGCCCATGGTCATCCTGCACCACCAGACCCTCCCTGCCAGCACC
CTCCGGAGAACCGAAGCCTTTGCTGACCTCTTCGCCGACTATGCCACATTCGCCTTCCAC
TCCTTCGGGGACCTAGTTGGGATCTGGTTCACCTTCAGTGACTTGGAGGAAGTGATCAAG
GAGCTTCCCCACCAGGAATCAAGAGCGTCACAACTCCAGACCCTCAGTGATGCCCACAGA
AAAGCCTATGAGATTTACCACGAAAGCTATGCTTTTCAGGGCGGAAAACTCTCTGTTGTC
CTGCGAGCTGAAGATATCCCGGAGCTCCTGCTAGAACCACCCATATCTGCGCTTGCCCAG
GACACGGTCGATTTCCTCTCTCTTGATTTGTCTTATGAATGCCAAAATGAGGCAAGTCTG
CGGCAGAAGCTGAGTAAATTGCAGACCATTGAGCCAAAAGTGAAAGTTTTCATCTTCAAC
CTAAAACTCCCAGACTGCCCCTCCACCATGAAGAACCCAGCCAGTCTGCTCTTCAGCCTT
TTTGAAGCCATAAATAAAGACCAAGTGCTCACCATTGGGTTTGATATTAATGAGTTTCTG
AGTTGTTCATCAAGTTCCAAGAAAAGCATGTCTTGTTCTCTGACTGGCAGCCTGGCCCTT
CAGCCTGACCAGCAGCAGGACCACGAGACCACGGACTCCTCTCCTGCCTCTGCCTATCAG
AGAGTCTGGGAAGCATTTGCCAATCAGTCCAGAGCGGAAAGGGATGCCTTCCTGCAGGAT
ACTTTCCCTGAAGGCTTCCTCTGGGGTGCCTCCACAGGAGCCTTTAACGTGGAAGGAGGC
TGGGCCGAGGGTGGGAGAGGGGTGAGCATCTGGGATCCACGCAGGCCCCTGAACACCACT
GAGGGCCAAGCGACGCTGGAGGTGGCCAGCGACAGTTACCACAAGGTAGCCTCTGACGTC
GCCCTGCTTTGCGGCCTCCGGGCTCAGGTGTACAAGTTCTCCATCTCCTGGTCCCGGATC
TTCCCCATGGGGCACGGGAGCAGCCCCAGCCTCCCAGGCGTTGCCTACTACAACAAGCTG
ATTGACAGGCTACAGGATGCGGGCATCGAGCCCATGGCCACGCTGTTCCACTGGGACCTG
CCTCAGGCCCTGCAGGATCATGGTGGATGGCAGAATGAGAGCGTGGTGGATGCCTTCCTG
GACTATGCGGCCTTCTGCTTCTCCACATTTGGGGACCGTGTGAAGCTGTGGGTGACCTTC
CATGAGCCGTGGGTGATGAGCTACGCAGGCTATGGCACCGGCCAGCACCCTCCCGGCATC
TCTGACCCAGGAGTGGCCTCTTTTAAGGTGGCTCACTTGGTCCTCAAGGCTCATGCCAGA
ACTTGGCACCACTACAACAGCCATCATCGCCCACAGCAGCAGGGGCACGTGGGCATTGTG
CTGAACTCAGACTGGGCAGAACCCCTGTCTCCAGAGAGGCCTGAGGACCTGAGAGCCTCT
GAGCGCTTCTTGCACTTCATGCTGGGCTGGTTTGCACACCCCGTCTTTGTGGATGGAGAC
TACCCAGCCACCCTGAGGACCCAGATCCAACAGATGAACAGACAGTGCTCCCATCCTGTG
GCTCAACTCCCCGAGTTCACAGAGGCAGAGAAGCAGCTCCTGAAAGGCTCTGCTGATTTT
CTGGGTCTGTCGCATTACACCTCCCGCCTCATCAGCAACGCCCCACAAAACACCTGCATC
CCTAGCTATGATACCATTGGAGGCTTCTCCCAACACGTGAACCATGTGTGGCCCCAGACC
TCATCCTCTTGGATTCGTGTGGTGCCCTGGGGGATAAGGAGGCTGTTGCAGTTTGTATCC
CTGGAATACACAAGAGGAAAAGTTCCAATATACCTTGCCGGGAATGGCATGCCCATAGGG
GAAAGTGAAAATCTCTTTGATGATTCCTTAAGAGTAGACTACTTCAATCAATATATCAAT
GAGGTGCTCAAGGCTATCAAGGAAGACTCTGTGGATGTTCGTTCCTACATTGCTCGTTCC
CTCATTGATGGCTTCGAAGGCCCTTCTGGTTACAGCCAGCGGTTTGGCCTGCACCACGTC
AACTTCAGCGACAGCAGCAAGTCAAGGACTCCCAGGAAATCTGCCTACTTTTTCACTAGC
ATCATAGAAAAGAACGGTTTCCTCACCAAGGGGGCAAAAAGACTGCTACCACCTAATACA
GTAAACCTCCCCTCCAAAGTCAGAGCCTTCACTTTTCCATCTGAGGTGCCCTCCAAGGCT
AAAGTCGTTTGGGAAAAGTTCTCCAGCCAACCCAAGTTCGAAAGAGATTTGTTCTACCAC
GGGACGTTTCGGGATGACTTTCTGTGGGGCGTGTCCTCTTCCGCTTATCAGATTGAAGGC
GCGTGGGATGCCGATGGCAAAGGCCCCAGCATCTGGGATAACTTTACCCACACACCAGGG
AGCAATGTGAAAGACAATGCCACTGGAGACATCGCCTGTGACAGCTATCACCAGCTGGAT
GCCGATCTGAATATGCTCCGAGCTTTGAAGGTGAAGGCCTACCGCTTCTCTATCTCCTGG
TCTCGGATTTTCCCAACTGGGAGAAACAGCTCTATCAACAGTCATGGGGTTGATTATTAC
AACAGGCTGATCAATGGCTTGGTGGCAAGCAACATCTTTCCCATGGTGACATTGTTCCAT
TGGGACCTGCCCCAGGCCCTCCAGGATATCGGAGGCTGGGAGAATCCTGCCTTGATTGAC
TTGTTTGACAGCTACGCAGACTTTTGTTTCCAGACCTTTGGTGATAGAGTCAAGTTTTGG
ATGACTTTTAATGAGCCCATGTACCTGGCATGGCTAGGTTATGGCTCAGGGGAATTTCCC
CCAGGGGTGAAGGACCCAGGCTGGGCACCATATAGGATAGCCCACACCGTCATCAAAGCC
CATGCCAGAGTCTATCACACGTACGATGAGAAATACAGGCAGGAGCAGAAGGGGGTCATC
TCGCTGAGCCTCAGTACACACTGGGCAGAGCCCAAGTCACCAGGGGTCCCCAGAGATGTG
GAAGCCGCTGACCGAATGCTGCAGTTCTCCCTGGGCTGGTTTGCTCACCCCATTTTTAGA
AACGGAGACTATCCTGACACCATGAAGTGGAAAGTGGGGAACAGGAGTGAACTGCAGCAC
TTAGCCACCTCCCGCCTGCCAAGCTTCACTGAGGAAGAGAAGAGGTTCATCAGGGCGACG
GCCGACGTCTTCTGCCTCAACACGTACTACTCCAGAATCGTGCAGCACAAAACACCCAGG
CTAAACCCACCCTCCTACGAAGACGACCAGGAGATGGCTGAGGAGGAGGACCCTTCGTGG
CCTTCCACGGCAATGAACAGAGCTGCGCCCTGGGGGACGCGAAGGCTGCTGAACTGGATC
AAGGAAGAGTATGGTGACATCCCCATTTACATCACCGAAAACGGAGTGGGGCTGACCAAT
CCGAACACGGAGGATACTGATAGGATATTTTACCACAAAACCTACATCAATGAGGCTTTG
AAAGCCTACAGGCTCGATGGTATAGACCTTCGAGGGTATGTCGCCTGGTCTCTGATGGAC
AACTTTGAGTGGCTAAATGGCTACACGGTCAAGTTTGGACTGTACCATGTTGATTTCAAC
AACACGAACAGGCCTCGCACAGCAAGAGCCTCCGCCAGGTACTACACAGAGGTCATTACC
AACAACGGCATGCCACTGGCCAGGGAGGATGAGTTTCTGTACGGACGGTTTCCTGAGGGC
TTCATCTGGAGTGCAGCTTCTGCTGCATATCAGATTGAAGGTGCGTGGAGAGCAGATGGC
AAAGGACTCAGCATTTGGGACACGTTTTCTCACACACCACTGAGGGTTGAGAACGATGCC
ATTGGAGACGTGGCCTGTGACAGTTATCACAAGATTGCTGAGGATCTGGTCACCCTGCAG
AACCTGGGTGTGTCCCACTACCGTTTTTCCATCTCCTGGTCTCGCATCCTCCCTGATGGA
ACCACCAGGTACATCAATGAAGCGGGCCTGAACTACTACGTGAGGCTCATCGATACACTG
CTGGCCGCCAGCATCCAGCCCCAGGTGACCATTTACCACTGGGACCTACCACAGACGCTC
CAAGATGTAGGAGGCTGGGAGAATGAGACCATCGTGCAGCGGTTTAAGGAGTATGCAGAT
GTGCTCTTCCAGAGGCTGGGAGACAAGGTGAAGTTTTGGATCACGTTGAATGAGCCCTTT
GTCATTGCTTACCAGGGCTATGGCTACGGAACAGCAGCTCCAGGAGTCTCCAATAGGCCT
GGCACTGCCCCCTACATTGTTGGCCACAATCTAATAAAGGCTCATGCTGAGGCCTGGCAT
CTGTACAACGATGTGTACCGCGCCAGTCAAGGTGGCGTGATTTCCATCACCATCAGCAGT
GACTGGGCTGAACCCAGAGATCCCTCTAACCAGGAGGATGTGGAGGCAGCCAGGAGATAT
GTTCAGTTCATGGGAGGCTGGTTTGCACATCCTATTTTCAAGAATGGAGATTACAATGAG
GTGATGAAGACGCGGATCCGTGACAGGAGCTTGGCTGCAGGCCTCAACAAGTCTCGGCTG
CCAGAATTTACAGAGAGTGAGAAGAGGAGGATCAACGGCACCTATGACTTTTTTGGGTTC
AATCACTACACCACTGTCCTCGCCTACAACCTCAACTATGCCACTGCCATCTCTTCTTTT
GATGCAGACAGAGGAGTTGCTTCCATCGCAGATCGCTCGTGGCCAGACTCTGGCTCCTTC
TGGCTGAAGATGACGCCTTTTGGCTTCAGGAGGATCCTGAACTGGTTAAAGGAGGAATAC
AATGACCCTCCAATTTATGTCACAGAGAATGGAGTGTCCCAGCGGGAAGAAACAGACCTC
AATGACACTGCAAGGATCTACTACCTTCGGACTTACATCAATGAGGCCCTCAAAGCTGTG
CAGGACAAGGTGGACCTTCGAGGATACACAGTTTGGAGTGCGATGGACAATTTTGAGTGG
GCCACAGGCTTTTCAGAGAGATTTGGTCTGCATTTTGTGAACTACAGTGACCCTTCTCTG
CCAAGGATCCCCAAAGCATCAGCGAAGTTCTACGCCTCTGTGGTCCGATGCAATGGCTTC
CCTGACCCCGCTACAGGGCCTCACGCTTGTCTCCACCAGCCAGATGCTGGACCCACCATC
AGCCCCGTGAGACAGGAGGAGGTGCAGTTCCTGGGGCTAATGCTCGGCACCACAGAAGCA
CAGACAGCTTTGTACGTTCTCTTTTCTCTTGTGCTTCTTGGAGTCTGTGGCTTGGCATTT
CTGTCATACAAGTACTGCAAGCGCTCTAAGCAAGGGAAAACACAACGAAGCCAACAGGAA
TTGAGCCCGGTGTCTTCATTCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X07994

# Metabolic_Enzyme_1_Chromosome_Location:
Not Available

# Metabolic_Enzyme_1_Locus:
Not Available

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
2460343; 1902057

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5602

# Metabolic_Enzyme_2_Name:
Neutral alpha-glucosidase AB precursor

# Metabolic_Enzyme_2_Synonyms:
Glucosidase II subunit alpha

# Metabolic_Enzyme_2_Gene_Name:
GANAB

# Metabolic_Enzyme_2_Protein_Sequence:
>Neutral alphaglucosidase AB precursor
MAAVAAVAARRRRSWASLVLAFLGVCLGITLAVDRSNFKTCEESSFCKRQRSIRPGLSPY
RALLDSLQLGPDSLTVHLIHEVTKVLLVLELQGLQKNMTRFRIDELEPRRPRYRVPDVLV
ADPPIARLSVSGRDENSVELTMAEGPYKIILTARPFRLDLLEDRSLLLSVNARGLLEFEH
QRAPRVSQGSKDPAEGDGAQPEETPRDGDKPEETQGKAEKDEPGAWEETFKTHSDSKPYG
PMSVGLDFSLPGMEHVYGIPEHADNLRLKVTEGGEPYRLYNLDVFQYELYNPMALYGSVP
VLLAHNPHRDLGIFWLNAAETWVDISSNTAGKTLFGKMMDYLQGSGETPQTDVRWMSETG
IIDVFLLLGPSISDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHN
LPCDVIWLDIEHADGKRYFTWDPSRFPQPRTMLERLASKRRKLVAIVDPHIKVDSGYRVH
EELRNLGLYVKTRDGSDYEGWCWPGSAGYPDFTNPTMRAWWANMFSYDNYEGSAPNLFVW
NDMNEPSVFNGPEVTMLKDAQHYGGWEHRDVHNIYGLYVHMATADGLRQRSGGMERPFVL
ARAFFAGSQRFGAVWTGDNTAEWDHLKISIPMCLSLGLVGLSFCGADVGGFFKNPEPELL
VRWYQMGAYQPFFRAHAHLDTGRREPWLLPSQHNDIIRDALGQRYSLLPFWYTLLYQAHR
EGIPVMRPLWVQYPQDVTTFNIDDQYLLGDALLVHPVSDSGAHGVQVYLPGQGEVWYDIQ
SYQKHHGPQTLYLPVTLSSIPVFQRGGTIVPRWMRVRRSSECMKDDPITLFVALSPQGTA
QGELFLDDGHTFNYQTRQEFLLRRFSFSGNTLVSSSADPEGHFETPIWIERVVIIGAGKP
AAVVLQTKGSPESRLSFQHDPETSVLVLRKPGINVASDWSIHLR

# Metabolic_Enzyme_2_Number_of_Residues:
944

# Metabolic_Enzyme_2_Molecular_Weight:
106875

# Metabolic_Enzyme_2_Theoretical_pI:
6.06

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins

# Metabolic_Enzyme_2_Pathway:
map00510  N-Glycan biosynthesis

# Metabolic_Enzyme_2_Reaction:
Hydrolysis of terminal 1,3-alpha-D-glucosidic links in 1,3-alpha-D-glucans

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01055:Glyco_hydro_31

# Metabolic_Enzyme_2_Signals:
1-28

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.2.1.84

# Metabolic_Enzyme_2_GenBank_ID_Protein:
2274968

# Metabolic_Enzyme_2_SwissProt_ID:
GANAB_HUMAN (Q14697)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
GANAB

# Metabolic_Enzyme_2_Geneatlas_id:
GANAB

# Metabolic_Enzyme_2_hgnc_id:
HGNC:4138

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Endoplasmic reticulum. Golgi apparatus (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Metabolic_Enzyme_2_Gene_Sequence:
>2835 bp
ATGGCGGCGGTAGCGGCAGTGGCGGCGCGTAGGAGGCGGTCTTGGGCGTCTTTGGTACTG
GCTTTTTTAGGGGTCTGCCTGGGGATTACCCTTGCTGTGGATAGAAGCAACTTTAAGACC
TGTGAAGAGAGTTCTTTCTGCAAGCGACAGAGAAGCATACGGCCAGGCCTCTCTCCATAC
CGAGCCTTGCTGGACTCTCTACAGCTTGGTCCTGATTCCCTCACGGTCCATCTGATCCAT
GAGGTCACCAAGGTGTTGCTGGTGCTAGAGCTTCAGGGGCTTCAAAAGAACATGACTCGG
TTCAGGATTGATGAGCTGGAGCCTCGGCGACCCCGATACCGTGTACCAGATGTTTTGGTG
GCTGATCCACCAATAGCCCGGCTTTCTGTCTCTGGTCGTGATGAGAACAGTGTGGAGTTA
ACCATGGCTGAGGGACCCTACAAGATCATCTTGACAGCACGGCCATTCCGCCTTGACCTA
CTAGAGGACCGAAGTCTTTTGCTTAGTGTCAATGCCCGAGGACTCTTGGAGTTTGAGCAT
CAGAGGGCCCCTAGGGTCTCGCAAGGATCAAAAGACCCAGCTGAGGGCGATGGGGCCCAG
CCTGAGGAAACACCCAGGGATGGCGACAAGCCAGAGGAGACTCAGGGGAAGGCAGAGAAA
GATGAGCCAGGAGCCTGGGAGGAGACATTCAAAACTCACTCTGACAGCAAGCCGTATGGC
CCCATGTCTGTGGGTTTGGACTTCTCTCTGCCAGGCATGGAGCATGTCTATGGGATCCCT
GAGCATGCAGACAACCTGAGGCTGAAGGTCACTGAGGGTGGGGAGCCATATCGCCTCTAC
AATTTGGATGTGTTCCAGTATGAGCTGTACAACCCAATGGCCTTGTATGGGTCTGTGCCT
GTGCTCCTGGCACACAACCCTCATCGCGACTTGGGCATCTTCTGGCTCAATGCTGCAGAG
ACCTGGGTTGATATATCTTCCAACACTGCCGGGAAGACCCTGTTTGGGAAGATGATGGAC
TACCTGCAGGGCTCTGGGGAGACCCCACAGACAGATGTTCGCTGGATGTCAGAGACTGGC
ATCATTGACGTCTTCCTGCTGCTGGGGCCCTCCATCTCTGATGTTTTCCGGCAATATGCT
AGTCTCACAGGAACCCAGGCGTTGCCCCCACTCTTCTCCCTCGGCTACCACCAGAGCCGT
TGGAACTACCGGGACGAGGCTGATGTGCTGGAAGTGGATCAGGGCTTTGATGATCACAAC
CTGCCCTGTGATGTCATCTGGCTAGACATTGAACATGCTGATGGCAAGCGGTATTTCACC
TGGGACCCCAGTCGCTTCCCTCAGCCCCGCACCATGCTTGAGCGCTTGGCTTCTAAGAGG
CGGAAGCTGGTGGCCATCGTAGACCCCCACATCAAGGTGGACTCCGGCTACCGAGTTCAC
GAGGAGCTGCGGAACCTGGGGCTGTATGTTAAAACCCGGGATGGCTCTGACTATGAGGGC
TGGTGCTGGCCAGGCTCAGCTGGTTACCCTGACTTCACTAATCCCACGATGAGGGCCTGG
TGGGCTAACATGTTCAGCTATGACAATTATGAGGGCTCAGCTCCCAACCTCTTTGTCTGG
AATGACATGAACGAACCATCTGTGTTCAATGGTCCTGAGGTCACCATGCTCAAGGATGCC
CAGCATTATGGGGGCTGGGAGCACCGGGATGTGCATAACATCTATGGCCTTTATGTGCAC
ATGGCGACTGCTGATGGGCTGAGACAGCGCTCTGGGGGCATGGAACGCCCCTTTGTCCTG
GCCAGGGCCTTCTTCGCTGGCTCCCAGCGCTTTGGAGCCGTGTGGACAGGGGACAACACT
GCCGAGTGGGACCATTTGAAGATCTCTATTCCTATGTGTCTCAGCTTGGGGCTGGTGGGA
CTTTCCTTCTGTGGGGCGGATGTGGGTGGCTTCTTCAAAAACCCAGAGCCAGAGCTGCTT
GTGCGCTGGTACCAGATGGGTGCTTACCAGCCATTCTTCCGGGCACATGCCCACTTGGAC
ACTGGGCGACGAGAGCCATGGCTGTTACCATCTCAGCACAATGATATAATCCGAGATGCC
TTGGGCCAGCGATATTCTTTGCTGCCCTTCTGGTACACCCTCTTATATCAGGCCCATCGG
GAAGGCATTCCTGTCATGAGGCCCCTGTGGGTGCAGTACCCTCAGGATGTGACTACCTTC
AATATAGATGATCAGTACTTGCTTGGGGATGCGTTGCTGGTTCACCCTGTATCAGACTCT
GGAGCCCATGGTGTCCAGGTCTATCTGCCTGGCCAAGGGGAGGTGTGGTATGACATTCAA
AGCTACCAGAAGCATCATGGTCCCCAGACCCTGTACCTGCCTGTAACTCTAAGCAGTATC
CCTGTGTTCCAGCGTGGAGGGACAATCGTGCCTCGATGGATGCGAGTGCGGCGGTCTTCA
GAATGTATGAAGGATGACCCCATCACTCTCTTTGTTGCACTTAGCCCTCAGGGTACAGCT
CAAGGAGAGCTCTTTCTGGATGATGGGTACACGTTCAACTATCAGACTCGCCAAGAGTTC
CTGCTGCGTCGATTCTCATTCTCTGGCAACACCCTTGTCTCCAGCTCAGCAGACCCTGAA
GGACACTTTGAGACACCAATCTGGATTGAGCGGGTGGTGATAATAGGGGCTGGAAAGCCA
GCAGCTGTGGTACTCCAGACAAAAGGATCTCCAGAAAGCCGCCTGTCCTTCCAGCATGAC
CCTGAGACCTCTGTGTTGGTCCTGCGCAAGCCTGGCATCAATGTGGCATCTGATTGGAGT
ATTCACCTGCGATAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AJ000332

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_2_Locus:
11q12.3

# Metabolic_Enzyme_2_SNPs:
rs1063445; rs2276296; rs2276295; rs2956993; rs7949030; rs948683; rs2958236; rs11231168; rs10897289; rs3017188; rs3017666; rs2956995; rs11231166; rs2956992; rs11231167; rs9736354; rs2957122; rs2958237; rs3018561; rs17855957; rs11559071; rs17855958; rs11559072; rs11600034; rs4995591; rs1815836; rs4995593; rs4997621; rs1815835; rs1815837; rs1815838; rs6916; rs4995592; rs11231169; rs10629749; rs2957119; rs34799148; rs11231170; rs12788805; rs34249342; rs2958233; rs2957121; rs11231172; rs511912; rs10561166; rs12270624; rs34969464; rs489886; rs10629748; rs10649859; rs511750; rs529170; rs34805341; rs662611; rs28600963; rs12288599; rs34798830; rs7395485; rs12364228; rs5792265; rs662604; rs2276298; rs2956994; rs36104523; rs34095634; rs11231171; rs12270159; rs36113826; rs34049415; rs34551849; rs34861606; rs35126727; rs11322640; rs7128852; rs34250565; rs34295065; rs11231164; rs11231165; rs11600264; rs15174; rs3750989; rs4963224; rs631714; rs7926862

# Metabolic_Enzyme_2_General_References:
10929008; 7788527

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5603

# Metabolic_Enzyme_3_Name:
Glycogen debranching enzyme

# Metabolic_Enzyme_3_Synonyms:
Glycogen debrancher[Includes: 4-alpha- glucanotransferase; Oligo-1,4-1,4-glucantransferase; Amylo-alpha-1,6-glucosidase; Amylo-1,6-glucosidase; Dextrin 6-alpha-D-glucosidase]

# Metabolic_Enzyme_3_Gene_Name:
AGL

# Metabolic_Enzyme_3_Protein_Sequence:
>Glycogen debranching enzyme
MGHSKQIRILLLNEMEKLEKTLFRLEQGYELQFRLGPTLQGKAVTVYTNYPFPGETFNRE
KFRSLDWENPTEREDDSDKYCKLNLQQSGSFQYYFLQGNEKSGGGYIVVDPILRVGADNH
VLPLDCVTLQTFLAKCLGPFDEWESRLRVAKESGYNMIHFTPLQTLGLSRSCYSLANQLE
LNPDFSRPNRKYTWNDVGQLVEKLKKEWNVICITDVVYNHTAANSKWIQEHPECAYNLVN
SPHLKPAWVLDRALWRFSCDVAEGKYKEKGIPALIENDHHMNSIRKIIWEDIFPKLKLWE
FFQVDVNKAVEQFRRLLTQENRRVTKSDPNQHLTIIQDPEYRRFGCTVDMNIALTTFIPH
DKGPAAIEECCNWFHKRMEELNSEKHRLINYHQEQAVNCLLGNVFYERLAGHGPKLGPVT
RKHPLVTRYFTFPFEEIDFSMEESMIHLPNKACFLMAHNGWVMGDDPLRNFAEPGSEVYL
RRELICWGDSVKLRYGNKPEDCPYLWAHMKKYTEITATYFQGVRLDNCHSTPLHVAEYML
DAARNLQPNLYVVAELFTGSEDLDNVFVTRLGISSLIREAMSAYNSHEEGRLVYRYGGEP
VGSFVQPCLRPLMPAIAHALFMDITHDNECPIVHRSAYDALPSTTIVSMACCASGSTRGY
DELVPHQISVVSEERFYTKWNPEALPSNTGEVNFQSGIIAARCAISKLHQELGAKGFIQV
YVDQVDEDIVAVTRHSPSIHQSVVAVSRTAFRNPKTSFYSKEVPQMCIPGKIEEVVLEAR
TIERNTKPYRKDENSINGTPDITVEIREHIQLNESKIVKQAGVATKGPNEYIQEIEFENL
SPGSVIIFRVSLDPHAQVAVGILRNHLTQFSPHFKSGSLAVDNADPILKIPFASLASRLT
LAELNQILYRCESEEKEDGGGCYDIPNWSALKYAGLQGLMSVLAEIRPKNDLGHPFCNNL
RSGDWMIDYVSNRLISRSGTIAEVGKWLQAMFFYLKQIPRYLIPCYFDAILIGAYTTLLD
TAWKQMSSFVQNGSTFVKHLSLGSVQLCGVGKFPSLPILSPALMDVPYRLNEITKEKEQC
CVSLAAGLPHFSSGIFRCWGRDTFIALRGILLITGRYVEARNIILAFAGTLRHGLIPNLL
GEGIYARYNCRDAVWWWLQCIQDYCKMVPNGLDILKCPVSRMYPTDDSAPLPAGTLDQPL
FEVIQEAMQKHMQGIQFRERNAGPQIDRNMKDEGFNITAGVDEETGFVYGGNRFNCGTWM
DKMGESDRARNRGIPATPRDGSAVEIVGLSKSAVRWLLELSKKNIFPYHEVTVKRHGKAI
KVSYDEWNRKIQDNFEKLFHVSEDPSDLNEKHPNLVHKRGIYKDSYGASSPWCDYQLRPN
FTIAMVVAPELFTTEKAWKALEIAEKKLLGPLGMKTLDPDDMVYCGIYDNALDNDNYNLA
KGFNYHQGPEWLWPIGYFLRAKLYFSRLMGPETTAKTIVLVKNVLSRHYVHLERSPWKGL
PELTNENAQYCPFSCETQAWSIATILETLYDL

# Metabolic_Enzyme_3_Number_of_Residues:
1532

# Metabolic_Enzyme_3_Molecular_Weight:
174766

# Metabolic_Enzyme_3_Theoretical_pI:
6.74

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  4-alpha-glucanotransferase activity
Function:  catalytic activity
Function:  glycogen debranching enzyme activity
Function:  amylo-alpha-1,6-glucosidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  polysaccharide metabolism
Process:  cellular polysaccharide metabolism
Process:  glucan metabolism
Process:  glycogen metabolism
Process:  glycogen biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6- glucosidase in glycogen degradation

# Metabolic_Enzyme_3_Pathway:
map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_3_Reaction:
Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF06202:GDE_C

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.4.1.25;EC 3.2.1.33

# Metabolic_Enzyme_3_GenBank_ID_Protein:
187577

# Metabolic_Enzyme_3_SwissProt_ID:
GDE_HUMAN (P35573)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
AGL

# Metabolic_Enzyme_3_Geneatlas_id:
AGL

# Metabolic_Enzyme_3_hgnc_id:
HGNC:321

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>4548 bp
ATGAGTTTATTAACATGTGCTTTTTATTTAGGGTATGAGCTACAGTTCCGATTAGGCCCA
ACTTTACAGGGAAAAGCAGTTACCGTGTATACAAATTACCCATTTCCTGGAGAAACATTT
AATAGAGAAAAATTCCGTTCTCTGGATTGGGAAAATCCAACAGAAAGAGAAGATGATTCT
GATAAATACTGTAAACTTAATCTGCAACAATCTGGTTCATTTCAGTATTATTTCCTTCAA
GGAAATGAGAAAAGTGGTGGAGGTTACATAGTTGTGGACCCCATTTTACGTGTTGGTGCT
GATAATCATGTGCTACCCTTGGACTGTGTTACTCTTCAGACATTTTTAGCTAAGTGTTTG
GGACCTTTTGATGAATGGGAAAGCAGACTTAGGGTTGCAAAAGAATCAGGCTACAACATG
ATTCATTTTACCCCATTGCAGACTCTTGGACTATCTAGGTCATGCTACTCCCTTGCCAAT
CAGTTAGAATTAAATCCTGACTTTTCAAGACCTAATAGAAAGTATACCTGGAATGATGTT
GGACAGCTAGTGGAAAAATTAAAAAAGGAATGGAATGTTATTTGTATTACTGATGTTGTC
TACAATCATACTGCTGCTAATAGTAAATGGATCCAGGAACATCCAGAATGTGCCTATAAT
CTTGTGAATTCTCCACACTTAAAACCTGCCTGGGTCTTAGACAGAGCACTTTGGCGTTTC
TCCTGTGATGTTGCAGAAGGGAAATACAAAGAAAAGGGAATACCTGCTTTGATTGAAAAT
GATCACCATATGAATTCCATCCGAAAAATAATTTGGGAGGATATTTTTCCAAAGCTTAAA
CTCTGGGAATTTTTCCAAGTAGATGTCAACAAAGCGGTTGAGCAATTTAGAAGACTTCTT
ACACAAGAAAATAGGCGAGTAACCAAGTCTGATCCAAACCAACACCTTACGATTATTCAA
GATCCTGAATACAGACGGTTTGGCTGTACTGTAGATATGAACATTGCACTAACGACTTTC
ATACCACATGACAAGGGGCCAGCAGCAATTGAAGAATGCTGTAATTGGTTTCATAAAAGA
ATGGAGGAATTAAATTCAGAGAAGCATCGACTCATTAACTATCATCAGGAACAGGCAGTT
AATTGCCTTTTGGGAAATGTGTTTTATGAACGACTGGCTGGCCATGGTCCAAAACTAGGA
CCTGTCACTAGAAAGCATCCTTTAGTTACCAGGTATTTTACTTTCCCATTTGAAGAGATA
GACTTCTCCATGGAAGAATCTATGATTCATCTGCCAAATAAAGCTTGTTTTCTGATGGCA
CACAATGGATGGGTAATGGGAGATGATCCTCTTCGAAACTTTGCTGAACCGGGTTCAGAA
GTTTACCTAAGGAGAGAACTTATTTGCTGGGGAGACAGTGTTAAATTACGCTATGGGAAT
AAACCAGAGGACTGTCCTTATCTCTGGGCACACATGAAAAAATACACTGAAATAACTGCA
ACTTATTTCCAGGGAGTACGTCTTGATAACTGCCACTCAACACCTCTTCACGTAGCTGAG
TACATGTTGGATGCTGCTAGGAATTTGCAACCCAATTTATATGTAGTAGCTGAACTGTTC
ACAGGAAGTGAAGATCTGGACAATGTCTTTGTTACTAGACTGGGCATTAGTTCCTTAATA
AGAGAGGCAATGAGTGCATATAATAGTCATGAAGAGGGCAGATTAGTTTACCGATATGGA
GGAGAACCTGTTGGATCCTTTGTTCAGCCCTGTTTGAGGCCTTTAATGCCAGCTATTGCA
CATGCCCTGTTTATGGATATTACGCATGATAATGAGTGTCCTATTGTGCATAGATCAGCG
TATGATGCTCTTCCAAGTACTACAATTGTTTCTATGGCATGTTGTGCTAGTGGAAGTACA
AGAGGCTATGATGAATTAGTGCCTCATCAGATTTCAGTGGTTTCTGAAGAACGGTTTTAC
ACTAAGTGGAATCCTGAAGCATTGCCTTCAAACACAGGTGAAGTTAATTTCCAAAGCGGC
ATTATTGCAGCCAGGTGTGCTATCAGTAAACTTCATCAGGAGCTTGGAGCCAAGGGTTTT
ATTCAGGTGTATGTGGATCAAGTTGATGAAGACATAGTGGCAGTAACAAGACACTCACCT
AGCATCCATCAGTCTGTTGTGGCTGTATCTAGAACTGCTTTCAGGAATCCCAAGACTTCA
TTTTACAGCAAGGAAGTGCCTCAAATGTGCATCCCTGGCAAAATTGAAGAAGTAGTTCTT
GAAGCTAGAACTATTGAGAGAAACACGAAACCTTATAGGAAGGATGAGAATTCAATCAAT
GGAACACCAGATATCACAGTAGAAATTAGAGAACATATTCAGCTTAATGAAAGTAAAATT
GTTAAACAAGCTGGAGTTGCCACAAAAGGGCCCAATGAATATATTCAAGAAATAGAATTT
GAAAACTTGTCTCCAGGAAGTGTTATTATATTCAGAGTTAGTCTTGATCCACATGCACAA
GTCGCTGTTGGAATTCTTCGAAATCATCTGACACAATTCAGTCCTCACTTTAAATCTGGC
AGCCTAGCTGTTGACAATGCAGATCCTATATTAAAAATTCCTTTTGCTTCTCTTGCCTCC
AGATTAACTTTGGCTGAGCTAAATCAGATCCTTTACCGATGTGAATCAGAAGAAAAGGAA
GATGGTGGAGGGTGCTATGACATACCAAACTGGTCAGCCCTTAAATATGCAGGTCTTCAA
GGTTTAATGTCTGTATTGGCAGAAATAAGACCAAAGAATGACTTGGGGCATCCTTTTTGT
AATAATTTGAGATCTGGAGATTGGATGATTGACTATGTCAGTAACCGGCTTATTTCACGA
TCAGGAACTATTGCTGAAGTTGGTAAATGGTTGCAGGCTATGTTCTTCTACCTGAAGCAG
ATCCCACGTTACCTTATCCCATGTTACTTTGATGCTATATTAATTGGTGCATATACCACT
CTTCTGGATACAGCATGGAAGCAGATGTCAAGCTTTGTTCAGAATGGTTCAACCTTTGTG
AAACACCTTTCATTGGGTTCAGTTCAACTGTGTGGAGTAGGAAAATTCCCTTCCCTGCCA
ATTCTTTCACCTGCCCTAATGGATGTACCTTATAGGTTAAATGAGATCACAAAAGAAAAG
GAGCAATGTTGTGTTTCTCTAGCTGCAGGCTTACCTCATTTTTCTTCTGGTATTTTCCGC
TGCTGGGGAAGGGATACTTTTATTGCACTTAGAGGTATACTGCTGATTACTGGACGCTAT
GTAGAAGCCAGGAATATTATTTTAGCATTTGCGGGTACCCTGAGGCATGGTCTCATTCCT
AATCTACTGGGTGAAGGGATTTATGCCAGATACAATTGTCGGGATGCTGTGTGGTGGTGG
CTGCAGTGTATCCAGGATTACTGTAAAATGGTTCCAAATGGTCTAGACATTCTCAAGTGC
CCAGTTTCCAGAATGTATCCTACAGATGATTCTGCTCCTTTGCCTGCTGGCACACTGGAT
CAGCCATTGTTTGAAGTCATACAGGAAGCAATGCAAAAACACATGCAGGGCATACAGTTC
CGAGAAAGGAATGCTGGTCCCCAGATAGATCGAAACATGAAGGACGAAGGTTTTAATATA
ACTGCAGGAGTTGATGAAGAAACAGGATTTGTTTATGGAGGAAATCGTTTCAATTGTGGC
ACATGGATGGATAAAATGGGAGAAAGTGACAGAGCTAGAAACAGAGGAATCCCAGCCACA
CCAAGAGATGGGTCTGCTGTGGAAATTGTGGGCCTGAGTAAATCTGCTGTTCGCTGGTTG
CTGGAATTATCCAAAAAAAATATTTTCCCTTATCATGAAGTCACAGTAAAAAGACATGGA
AAGGCTATAAAGGTCTCATATGATGAGTGGAACAGAAAAATACAAGACAACTTTGAAAAG
CTATTTCATGTTTCCGAAGACCCTTCAGATTTAAATGAAAAGCATCCAAATCTGGTTCAC
AAACGTGGCATATACAAAGATAGTTATGGAGCTTCAAGTCCTTGGTGTGACTATCAGCTC
AGGCCTAATTTTACCATAGCAATGGTTGTGGCCCCTGAGCTCTTTACTACAGAAAAAGCA
GGGAAAGCTTTGGAGATTGCAGAAAAAAAATTGCTTGGTCCCCTTGGCATGAAAACTTTA
GATCCAGATGATATGGTTTACTGTGGAATTTATGACAATGCATTAGACAATGACAACTAC
AATCTTGCTAAAGGTTTCAATTATCACCAAGGACCTGAGTGGCTGTGGCCTATTGGGTAT
TTTCTTCGTGCAAAATTATATTTTTCCAGATTGATGGGCCCGGAGACTACTGCAAAGACT
ATAGTTTTGGTTAAAAATGTTCTTTCCCGACATTATGTTCATCTTGAGAGATCCCCTTGG
AAAGGACTTCCAGAACTGACCAATGAGAATGCCCAGTACTGTCCTTTCAGCTGTGAAACA
CAAGCCTGGTCAATTGCTACTATTCTTGAGACACTTTATGATTTATAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M85168

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_3_Locus:
1p21

# Metabolic_Enzyme_3_SNPs:
rs7536086; rs17121403; rs17121464; rs3753494; rs11807956; rs2230308; rs3736297; rs34714252; rs35278779; rs12043139; rs2230306; rs2230305; rs28730706; rs1804809; rs1804808; rs3766601; rs3766591; rs3766600; rs2307130; rs2307129; rs3766603; rs7513618; rs17121319; rs663848; rs12563807; rs12117747; rs2640911; rs628842; rs512237; rs569488; rs633127; rs634880; rs555929; rs574592; rs1493616; rs2035960; rs2291637; rs2814038; rs632699; rs631797; rs602700; rs618539; rs844323; rs494740; rs3766599; rs3766594; rs903126; rs2274570; rs659030; rs3766595; rs2035958; rs700537; rs2234707; rs655435; rs11166369; rs6577145; rs3766597; rs3820156; rs486408; rs2035961; rs2392077; rs12038567; rs598488; rs6577141; rs7528537; rs3736295; rs10875274; rs620281; rs6577148; rs656572; rs535461; rs590623; rs3766596; rs10783121; rs10747505; rs11166375; rs6692695; rs6577144; rs1541041; rs10875275; rs6577149; rs2291638; rs489681; rs594249; rs3820157; rs3820155; rs538389; rs17409324; rs481102; rs11166366; rs579660; rs619445; rs17121609; rs3736296; rs6577143; rs3753491; rs12039074; rs11581066; rs10783123; rs11166364; rs11166371; rs12080767; rs482825; rs903125; rs7519706; rs11800612; rs2769699; rs539157; rs3753490; rs17121466; rs2784169; rs3766593; rs17450126; rs6577142; rs572231; rs653389; rs494626; rs672069; rs3818568; rs515957; rs12035706; rs2296885; rs11166368; rs2769698; rs11166367; rs577954; rs1577541; rs11805563; rs492032; rs17448792; rs567596; rs6674610; rs530824; rs4307591; rs11166361; rs4908033; rs7554495; rs17450460; rs4907900; rs10783122; rs6659531; rs2307533; rs11166374; rs600777; rs17121546; rs685108; rs834575; rs11166363; rs17121622; rs7552875; rs687979; rs12073608; rs1932442; rs17121571; rs7555316; rs534662; rs17121617; rs12141927; rs7526847; rs6577146; rs12045983; rs17121414; rs6676595; rs4908034; rs578793; rs17121580; rs12754517; rs531015; rs6665958; rs12756830; rs686654; rs3753492; rs12086095; rs6577147; rs17121644; rs11166370; rs17121583; rs10157467; rs17121560; rs3766592; rs971245; rs17121311; rs3753486; rs28730701; rs41285738; rs28730708; rs12118058; rs41285740; rs34230588; rs34187957; rs34314491; rs11459891; rs35402482; rs11363065; rs1042291; rs12045176; rs41285742; rs41285736; rs1042285; rs3835491; rs34100797; rs35386840; rs496379; rs12757018; rs12732272; rs35486459; rs7410954; rs34696246; rs6669911; rs34941922; rs11308048; rs11354427; rs35373898; rs12035163; rs2640917; rs36007479; rs5776495; rs7533378; rs34561608; rs481932; rs35451680; rs12089187; rs34150660; rs34414844; rs2784168; rs12039154; rs4589132; rs6659534; rs10631915; rs34936033; rs674923; rs28730707; rs34530728; rs584264; rs36042909; rs17121634; rs12760862; rs9434035; rs684047; rs35532025; rs518500; rs6659536; rs3753493; rs11166372; rs34675960; rs12744819; rs11166362; rs479102; rs12734255; rs10628111; rs35274839; rs34177499; rs6674718; rs613762; rs6701460; rs638061; rs661874; rs34959224; rs2769697; rs34057901; rs3834029; rs11396034; rs12734024; rs28730703; rs11299217; rs35461239; rs34432483; rs4907898; rs11298471; rs548255; rs17121509; rs11275374; rs683214; rs10606259; rs1070281; rs700538; rs34782984; rs11372707; rs683124; rs2814039; rs571608; rs545045; rs1389381; rs6685484; rs2640916; rs34959197; rs12742273; rs28730704; rs34892303; rs12026350; rs34598850; rs7554622; rs12045937; rs35430266; rs34375591; rs35306093; rs834664; rs34401149; rs6659532; rs11368135; rs34531887; rs11166365; rs28730702; rs6691199; rs12092860; rs542508; rs10536621; rs12756297; rs3956694; rs7533698; rs11279753; rs35529979; rs11291815; rs6674605; rs35353104; rs34764737; rs649184; rs28468683; rs12045385; rs10631914; rs35114973; rs12730946; rs4907899; rs11438303; rs12037862; rs35740001; rs10615193; rs12729314; rs34853132; rs11166359; rs28575824; rs12092273; rs12143270; rs34436422; rs35956186; rs28474918; rs11166373; rs12742594; rs35616696; rs35773080; rs6674973; rs12734023; rs10637207; rs35513593; rs2814040; rs35650560; rs566460; rs12125517; rs34944425; rs35856689; rs11579334; rs11805862; rs12728741; rs17121306; rs2149188; rs2149189; rs2392075; rs4908036; rs501014; rs520644; rs573196; rs645956; rs6659858; rs6681572; rs6704456

# Metabolic_Enzyme_3_General_References:
1374391; 8954797; 9332391; 10982190; 10571954

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5444

# Metabolic_Enzyme_4_Name:
Hexokinase-3

# Metabolic_Enzyme_4_Synonyms:
Hexokinase type III; HK III

# Metabolic_Enzyme_4_Gene_Name:
HK3

# Metabolic_Enzyme_4_Protein_Sequence:
>Hexokinase3
MDSIGSSGLRQGEETLSCSEEGLPGPSDSSELVQECLQQFKVTRAQLQQIQASLLGSMEQ
ALRGQASPAPAVRMLPTYVGSTPHGTEQGDFVVLELGATGASLRVLWVTLTGIEGHRVEP
RSQEFVIPQEVMLGAGQQLFDFAAHCLSEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRST
LISWTKGFRCSGVEGQDVVQLLRDAIRRQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVG
LVVDTGTNACYMEEARHVAVLDEDRGRVCVSVEWGSLSDDGALGPVLTTFDHTLDHESLN
PGAQRFEKMIGGLYLGELVRLVLAHLARCGVLFGGCTSPALLSQGSILLEHVAEMEDPST
GAARVHAILQDLGLSPGASDVELVQHVCAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQ
VAVATGGRVCERHPRFCSVLQGTVMLLAPECDVSLIPSVDGGGRGVAMVTAVAARLAAHR
RLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASSLRMLPTFVRATPDGSERGDFLA
LDLGGTNFRVLLVRVTTGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQ
SLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAI
VNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGD
DGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQ
RLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLC
GAGVAAVVEKIRGNRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSE
DGSGKGAALVTAVACRLAQLTRV

# Metabolic_Enzyme_4_Number_of_Residues:
923

# Metabolic_Enzyme_4_Molecular_Weight:
98921

# Metabolic_Enzyme_4_Theoretical_pI:
5.11

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_4_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism;
 map00521  Streptomycin biosynthesis;
 map00530  Aminosugars metabolism

# Metabolic_Enzyme_4_Reaction:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00349:Hexokinase_1;
PF03727:Hexokinase_2

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.7.1.1

# Metabolic_Enzyme_4_GenBank_ID_Protein:
1255788

# Metabolic_Enzyme_4_SwissProt_ID:
HXK3_HUMAN (P52790)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
HK3

# Metabolic_Enzyme_4_Geneatlas_id:
HK3

# Metabolic_Enzyme_4_hgnc_id:
HGNC:4925

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>2772 bp
ATGGACTCCATTGGGTCTTCAGGGTTGCGGCAGGGGGAAGAAACCCTGAGTTGCTCTGAG
GAGGGCTTGCCCGGGCCCTCAGACAGCTCAGAGCTGGTGCAGGAGTGCCTGCAGCAGTTC
AAGGTGACAAGGGCACAGCTACAGCAGATCCAAGCCAGCCTCTTGGGTTCCATGGAGCAG
GCGCTGAGGGGACAGGCCAGCCCTGCCCCTGCGGTCCGGATGCTGCCTACATACGTGGGG
TCCACCCCACATGGCACTGAGCAAGGAGACTTCGTGGTGCTGGAGCTGGGGGCCACAGGG
GCCTCACTGCGTGTTTTGTGGGTGACTCTAACTGGCATTGAGGGGCATAGGGTGGAGCCC
AGAAGCCAGGAGTTTGTGATCCCCCAAGAGGTGATGCTGGGTGCTGGCCAGCAGCTCTTT
GACTTTGCTGCCCACTGCCTGTCTGAGTTCCTGGATGCGCAGCCTGTGAACAAACAGGGT
CTGCAGCTTGGCTTCAGCTTCTCTTTCCCTTGTCACCAGACGGGCTTGGACAGGAGCACC
CTCATTTCCTGGACCAAAGGTTTTAGGTGCAGTGGTGTGGAAGGCCAGGATGTGGTCCAG
CTGCTGAGAGATGCCATTCGGAGGCAGGGGGCCTACAACATCGACGTGGTTGCTGTGGTG
AACGACACAGTGGGCACCATGATGGGCTGTGAGCCGGGGGTCAGGCCGTGTGAGGTTGGG
CTAGTTGTAGACACGGGCACCAACGCGTGTTACATGGAGGAGGCACGGCATGTGGCAGTG
CTGGACGAAGACCGGGGCCGCGTCTGCGTCAGCGTCGAGTGGGGCTCCTTAAGCGATGAT
GGGGCGCTGGGACCAGTGCTGACCACCTTCGACCATACCCTGGACCATGAGTCCCTGAAT
CCTGGTGCTCAGAGGTTTGAGAAGATGATCGGAGGCCTGTACCTGGGTGAGCTGGTGCGG
CTGGTGCTGGCTCACTTGGCCCGGTGTGGGGTCCTCTTTGGTGGCTGCACCTCCCCTGCC
CTGCTGAGCCAAGGCAGCATCCTCCTGGAACACGTGGCTGAGATGGAGGACCCCTCTACT
GGGGCAGCCCGTGTCCATGCTATCCTGCAGGACTTGGGCCTGAGCCCTGGGGCTTCGGAT
GTTGAGCTTGTGCAGCACGTCTGTGCGGCCGTGTGCACGCGGGCTGCCCAGCTCTGTGCT
GCCGCCCTGGCCGCTGTTCTCTCCTGCCTCCAGCACAGCCGGGAGCAACAAACACTCCAG
GTTGCTGTGGCCACCGGAGGCCGAGTGTGTGAGCGGCACCCCAGGTTCTGCAGCGTCCTG
CAGGGGACAGTGATGCTCCTGGCCCCGGAATGCGATGTCTCCTTAATCCCCTCTGTGGAT
GGTGGTGGCCGGGGAGTGGCGATGGTGACTGCTGTGGCTGCCCGTCTGGCTGCCCACCGG
CGCCTGCTGGAGGAGACCCTGGCCCCATTCCGGTTGAACCATGATCAACTGGCTGCGGTT
CAGGCACAGATGCGGAAGGCCATGGCCAAGGGGCTCCGAGGGGAGGCCTCCTCCCTTCGC
ATGCTGCCCACTTTCGTCCGGGCCACCCCTGACGGCAGCGAGCGAGGGGATTTCCTGGCC
CTGGACCTCGGGGGCACGAACTTCCGTGTCCTCCTGGTACGTGTGACCACAGGCGTGCAG
ATCACCAGCGAGATCTACTCCATTCCCGAGACTGTGGCCCAGGGTTCTGGGCAGCAGCTC
TTTGACCACATCGTGGACTGCATCGTGGACTTCCAGCAGAAGCAGGGCCTGAGCGGGCAG
AGCCTCCCACTGGGTTTTACCTTCTCCTTCCCATGTAGGCAGCTTGGCCTAGACCAGGGC
ATCCTCCTGAACTGGACCAAGGGTTTCAAGGCATCAGACTGCGAGGGCCAAGATGTCGTG
AGTCTGTTGCGGGAAGCCATCACTCGCAGACAGGCAGTGGAGCTGAATGTGGTTGCCATT
GTCAATGACACGGTGGGGACCATGATGTCCTGTGGCTATGAGGACCCCCGTTGCGAGATA
GGCCTCATTGTCGGAACCGGCACCAATGCCTGCTACATGGAGGAGCTCCGGAATGTGGCG
GGCGTGCCTGGGGACTCAGGCCGCATGTGCATCAACATGGAGTGGGGCGCCTTTGGGGAC
GATGGCTCTCTGGCCATGCTCAGCACCCGCTTTGATGCAAGTGTGGACCAGGCGTCCATC
AACCCCGGCAAGCAGAGGTTTGAAAAGATGATCAGCGGCATGTACCTGGGGGAGATCGTC
CGCCACATCCTTTTACATTTAACCAGCCTTGGCGTTCTCTTCCGGGGCCAGCAGATCCAG
CGCCTTCAGACCAGGGACATCTTCAAGACCAAGTTCCTCTCTGAGATCGAAAGTGACAGC
CTGGCCCTGCGGCAGGTCCGAGCCATCCTAGAGGATCTGGGGCTACCCCTGACCTCAGAT
GACGCCCTGATGGTGCTAGAGGTGTGCCAGGCTGTGTCCCAGAGGGCTGCCCAGCTCTGT
GGGGCGGGTGTAGCTGCCGTGGTGGAGAAGATCCGGGGGAACCGGGGCCTGGAAGAGCTG
GCAGTGTCTGTGGGGGTGGATGGAACGCTCTACAAGCTGCACCCGCGCTTCTCCAGCCTG
GTGGCGGCCACAGTGCGGGAGCTGGCCCCTCGCTGTGTGGTCACGTTCCTGCAGTCAGAG
GATGGGTCCGGCAAAGGTGCGGCCCTGGTCACCGCTGTTGCCTGCCGCCTTGCGCAGTTG
ACTCGTGTCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
U51333

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_4_Locus:
5q35.2

# Metabolic_Enzyme_4_SNPs:
rs35610191; rs2278492; rs6875296; rs6861925; rs691141; rs691541; rs11135005; rs493578; rs691583; rs691057; rs522150; rs4976661; rs2278493; rs4976662; rs539822; rs691276; rs7716812; rs541807; rs12519232; rs479270; rs692200; rs10064961; rs3792729; rs12187462; rs691044; rs2278494; rs7736787; rs691693; rs691866; rs547798; rs3762971; rs812246; rs692129; rs2304514; rs35676647; rs34127573; rs494450; rs34497240; rs35226830; rs34468066; rs36002077; rs576380; rs34792080; rs36056969; rs6897020; rs35738781; rs4976631; rs35622796; rs4976663; rs691009; rs691473; rs34391089; rs3792730; rs35417166; rs691477; rs10056854; rs3762972; rs3762973; rs10543717; rs35180023; rs1043930; rs10475632; rs10475633; rs11953674; rs12422; rs1472920; rs2292255; rs2292256; rs2292257; rs2304515; rs2304516; rs2304517; rs2940531; rs2962835; rs2962844; rs2962845; rs3736431; rs3736432; rs3762974; rs475533; rs478253; rs490368; rs4976630; rs506370; rs690885; rs692011; rs9313744

# Metabolic_Enzyme_4_General_References:
8812439; 8717435

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5445

# Metabolic_Enzyme_5_Name:
Hexokinase-2

# Metabolic_Enzyme_5_Synonyms:
Hexokinase type II; HK II; Muscle form hexokinase

# Metabolic_Enzyme_5_Gene_Name:
HK2

# Metabolic_Enzyme_5_Protein_Sequence:
>Hexokinase2
MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAA
VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMR
GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV
EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYME
EMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGM
YMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLG
LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKH
PHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLS
HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV
LLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF
TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG
TMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD
FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG
IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA
VVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKG
AALITAVACRIREAGQR

# Metabolic_Enzyme_5_Number_of_Residues:
917

# Metabolic_Enzyme_5_Molecular_Weight:
102381

# Metabolic_Enzyme_5_Theoretical_pI:
5.93

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_5_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism;
 map00521  Streptomycin biosynthesis;
 map00530  Aminosugars metabolism

# Metabolic_Enzyme_5_Reaction:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00349:Hexokinase_1;
PF03727:Hexokinase_2

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.7.1.1

# Metabolic_Enzyme_5_GenBank_ID_Protein:
587202

# Metabolic_Enzyme_5_SwissProt_ID:
HXK2_HUMAN (P52789)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
HK2

# Metabolic_Enzyme_5_Geneatlas_id:
HK2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:4923

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding (By similarity)

# Metabolic_Enzyme_5_Gene_Sequence:
>2754 bp
ATGATTGCCTCGCATCTGCTTGCCTACTTCTTCACGGAGCTCAACCATGACCAAGTGCAG
AAGGTTGACCAGTATCTCTACCACATGCGCCTCTCTGATGAGACCCTCTTGGAGATCTCT
AAGCGGTTCCGCAAGGAGATGGAGAAAGGGCTTGGAGCCACCACTCACCCTACTGCAGCA
GTGAAGATGCTGCCCACCTTTGTGAGGTCCACTCCAGATGGGACAGAACACGGAGAGTTC
CTGGCTCTGGATCTTGGAGGGACCAACTTCCGTGTGCTTTGGGTGAAAGTAACGGACAAT
GGGCTCCAGAAGGTGGAGATGGAGAATCAGATCTATGCCATCCCTGAGGACATCATGCGA
GGCAGTGGCACCCAGCTGTTTGACCACATTGCCGAATGCCTGGCTAACTTCATGGATAAG
CTACAAATCAAAGACAAGAAGCTCCCACTGGGTTTTACCTTCTCGTTCCCCTGCCACCAG
ACTAAACTAGACGAGAGTTTCCTGGTCTCATGGACCAAGGGATTCAAGTCCAGTGGAGTG
GAAGGCAGAGACGTTGTGGCTCTGATCCGGAAGGCCATCCAGAGGAGAGGGGACTTTGAT
ATCGACATTGTGGCTGTGGTGAATGACACAGTTGGGACCATGATGACCTGTGGTTATGAT
GACCACAACTGTGAGATTGGTCTCATTGTGGGCACGGGCAGCAACGCCTGCTACATGGAA
GAGATGCGCCACATCGACATGGTGGAAGGCGATGAGGGGCGGATGTGTATCAATATGGAG
TGGGGGGCCTTCGGGGACGATGGCTCGCTCAACGACATTCGCACTGAGTTTGACCAGGAG
ATTGACATGGGCTCACTGAACCCGGGAAAGCAACTGTTTGAGAAGATGATCAGTGGGATG
TACATGGGGGAGCTGGTGAGGCTTATCCTGGTGAAGATGGCCAAGGAGGAGCTGCTCTTT
GGGGGGAAGCTCAGCCCAGAGCTTCTCAACACCGGTCGCTTTGAGACCAAAGACATCTCA
GACATTGAAGGGGAGAAGGATGGCATCCGGAAGGCCCGTGAGGTCCTGATGCGGTTGGGC
CTGGACCCGACTCAGGAGGACTGCGTGGCCACTCACCGGATCTGCCAGATCGTGTCCACA
CGCTCCGCCAGCCTGTGCGCAGCCACCCTGGCCGCCGTGCTGCAGCGCATCAAGGAGAAC
AAAGGCGAGGAGCGGCTGCGCTCTACTATTGGGGTCGACGGTTCCGTCTACAAGAAACAC
CCCCATTTTGCCAAGCGTCTACATAAGACCGTGCGGCGGCTGGTGCCCGGCTGCGATGTC
CGCTTCCTCCGCTCCGAGGATGGCAGTGGCAAAGGTGCAGCCATGGTGACAGCAGTGGCT
TACCGGCTGGCCGATCAACACCGTGCCCGCCAGAAGACATTAGAGCATCTGCAGCTGAGC
CATGACCAGCTGCTGGAGGTCAAGAGGAGGATGAAGGTAGAAATGGAGCGAGGTCTGAGC
AAGGAGACTCATGCCAGTGCCCCCGTCAAGATGCTGCCCACCTACGTGTGTGCTACCCCG
GACGGCACAGAGAAAGGGGACTTCTTGGCCTTGGACCTTGGAGGAACAAATTTCCGGGTC
CTGCTGGTCCGTGTTCGGAATGGGAAGTGGGGTGGAGTGGAGATGCACAACAAGATCTAC
GCCATCCCGCAGGAGGTCATGCACGGCACCGGGGACGAGCTCTTTGACCACATTGTCCAG
TGCATCGCGGACTTCCTCGAGTACATGGGCATGAAGGGCGTGTCCCTGCCTCTGGGTTTT
ACCTTCTCCTTCCCCTGCCAGCAGAACAGCCTGGACGAGAGCATCCTCCTCAAGTGGACA
AAAGGCTTCAAGGCATCTGGCTGCGAGGGCGAGGACGTGGTGACCCTGCTGAAGGAAGCG
ATCCACCGGCGAGAGGAGTTTGACCTGGATGTGGTTGCTGTGGTGAACGACACAGTCGGA
ACTATGATGACCTGTGGCTTTGAAGACCCTCACTGTGAAGTTGGCCTCATTGTTGGCACG
GGCAGCAATGCCTGCTACATGGAGGAGATGCGCAACGTGGAACTGGTGGAAGGAGAAGAG
GGGCGGATGTGTGTGAACATGGAATGGGGGGCCTTCGGGGACAATGGATGCCTAGATGAC
TTCCGCACAGAATTTGATGTGGCTGTGGATGAGCTTTCACTCAACCCCGGCAAGCAGAGG
TTCGAGAAAATGATCAGTGGAATGTACCTGGGTGAGATTGTCCGTAACATTCTCATCGAT
TTCACCAAGCGTGGACTACTCTTCCGAGGCCGCATCTCAGAGCGGCTCAAGACAAGGGGC
ATCTTTGAAACCAAGTTCTTGTCTCAGATTGAGAGTGACTGCCTGGCCCTGCTGCAAGTC
CGAGCCACCCTGCAACACTTAGGGCTTGAGAGCACCTGTGACGACAGCATCATTGTTAAG
GAGGTGTGCACTGTGGTGGCCCGGCGGGCAGCCCAGCTCTGTGGCGCAGGCATGGCCGCT
GTGGTGGACAGGATACGAGAAAACCGTGGGCTGGACGCTCTCAAAGTGACAGTGGGTGTG
GATGGGACCCTCTACAAGCTACATCCTCACTTTGCCAAAGTCATGCATGAGACAGTGAAG
GACCTGGCTCCGAAATGTGATGTGTCTTTCCTGCAGTCAGAGGATGGCAGCGGGAAGGGG
GCGGCGCTCATCACTGCTGTGGCCTGCCGCATCCGTGAGGCTGGACAGCGATAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
Z46376

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_5_Locus:
2p13

# Metabolic_Enzyme_5_SNPs:
rs2229629; rs3732299; rs28363029; rs28363015; rs2306808; rs2229626; rs10194657; rs2229622; rs28363033; rs28363014; rs943; rs656489; rs9679561; rs3832165; rs3732298; rs3732295; rs3821305; rs3732296; rs28363066; rs1061314; rs28384370; rs28362959; rs28363067; rs28384369; rs651071; rs2279429; rs1545522; rs681900; rs923273; rs1545523; rs1872837; rs3771755; rs4853066; rs1565064; rs3771782; rs3771772; rs3821307; rs11893422; rs680545; rs6732614; rs3771754; rs678350; rs11903758; rs11694331; rs694644; rs6754642; rs1032206; rs1869339; rs3771798; rs11688312; rs3771770; rs2171385; rs1487371; rs13395967; rs685363; rs6735303; rs3771781; rs4853069; rs3771752; rs6730141; rs2306806; rs3771756; rs4241264; rs10153633; rs3771771; rs3771763; rs3816456; rs17010492; rs11688305; rs13384240; rs3755454; rs3821310; rs11675401; rs2279428; rs6749471; rs10496195; rs28363012; rs3771751; rs3732300; rs28362967; rs4852347; rs3771786; rs3771759; rs3755453; rs6722578; rs4853067; rs28362977; rs3771768; rs3771773; rs28362973; rs3771783; rs3771760; rs3821309; rs1869340; rs4853064; rs3771758; rs3771769; rs11888976; rs3755452; rs2068358; rs10153634; rs17741356; rs3732301; rs4853068; rs3771753; rs6752205; rs11675438; rs4853065; rs6720940; rs2306805; rs3771790; rs3771766; rs17010467; rs28363062; rs13382443; rs3771761; rs28362980; rs28362969; rs3771775; rs10183051; rs3821311; rs3771762; rs604207; rs2123615; rs28362972; rs3755450; rs1807090; rs7602790; rs602898; rs634849; rs28363004; rs3771792; rs13394603; rs17010460; rs675611; rs28363048; rs28746193; rs28363047; rs28362983; rs28363042; rs28363035; rs28363055; rs28362999; rs28363003; rs3771788; rs28363044; rs3771793; rs5832141; rs28363060; rs28362996; rs3821308; rs11680091; rs2901626; rs3771778; rs11126442; rs28363053; rs28363021; rs17010436; rs28363011; rs11675530; rs28363054; rs28362979; rs28363008; rs28362968; rs6709975; rs28362997; rs13389855; rs28363032; rs2422043; rs17010464; rs842667; rs28363028; rs28362993; rs3078015; rs28362965; rs3755451; rs28363040; rs28362981; rs604112; rs3771784; rs28362964; rs13405909; rs663504; rs28363037; rs1565063; rs603743; rs6756096; rs13398307; rs28363027; rs28363049; rs13397480; rs11894886; rs17010504; rs28363031; rs28362987; rs28362990; rs4852348; rs28363023; rs3771767; rs2279427; rs3771785; rs28746191; rs680015; rs35902493; rs28362986; rs3771791; rs28363000; rs28363041; rs17847166; rs1386536; rs3821306; rs7572459; rs10496196; rs10496197; rs28363016; rs28363065; rs17847161; rs35677390; rs36066402; rs28363057; rs35396457; rs28363006; rs17847160; rs28363005; rs28363051; rs11556194; rs3202369; rs3732302; rs13429546; rs34573284; rs3832164; rs28384371; rs28362960; rs6741953; rs11556193; rs28384372; rs28384368; rs10451660; rs28362991; rs6755864; rs28363026; rs28363056; rs34315149; rs35716613; rs11689606; rs28363061; rs2029236; rs28362988; rs28363050; rs28363043; rs684491; rs28363034; rs2901627; rs11295383; rs5832143; rs618023; rs28362963; rs28362995; rs28363059; rs35137588; rs34780455; rs13432314; rs28363022; rs11450211; rs34286902; rs35601612; rs2422045; rs28362971; rs3771776; rs13395815; rs34063910; rs636903; rs28362978; rs6707123; rs5832142; rs6743207; rs35570397; rs13386610; rs676065; rs28362992; rs28363007; rs34662031; rs3836190; rs17847145; rs28362962; rs28363058; rs28363039; rs35888944; rs13387771; rs13004379; rs28362974; rs28362984; rs3836189; rs28362989; rs600578; rs35586432; rs28363064; rs10675736; rs6708938; rs17847149; rs35315423; rs10175889; rs28363019; rs3077985; rs35276905; rs28363036; rs35227945; rs3771787; rs35771648; rs7604247; rs2422046; rs3771774; rs11459447; rs28567425; rs35641789; rs11369279; rs6753090; rs28362961; rs11688513; rs11300678; rs28363018; rs10169547; rs28363024; rs34066885; rs6728248; rs7596751; rs28363010; rs28363002; rs36226712; rs28363052; rs34552028; rs2901628; rs28362976; rs3836188; rs28363046; rs7557784; rs17847165; rs35591732; rs28363063; rs28363020; rs28363025; rs28362985; rs28363009; rs34553329; rs35969102; rs28746192; rs7596131; rs10688878; rs35605685; rs2422044; rs34611487; rs28363017; rs3836187; rs28362982; rs17847158; rs36027258; rs5832144; rs28363001; rs34885061; rs41498345; rs28362994; rs34743801; rs34980367; rs636472; rs34106533; rs28969559; rs11308687; rs28363013; rs28363045; rs28363038; rs28362966; rs34842573; rs13020188; rs28362970; rs3771779; rs35454195; rs3771780; rs28746194; rs3771796; rs7600390; rs34021969; rs13411123; rs28362975; rs28362998; rs28363030; rs13013519; rs10865403; rs28384373; rs7424799; rs35575305; rs608112; rs659635; rs619850; rs3887287; rs35614058; rs35250889; rs10865404; rs11892954; rs12151815; rs1565068; rs17678046; rs17678088; rs2087173; rs2129603; rs34610149; rs4241265; rs4443023; rs4443024; rs4549114; rs4853059; rs5020284; rs628983; rs6546935; rs657209; rs670083; rs6730659; rs6758134; rs748357; rs7571422; rs7596427; rs7597871

# Metabolic_Enzyme_5_General_References:
8786021; 8250948; 7518342; 7883120; 7883122; 7883123

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5604

# Metabolic_Enzyme_6_Name:
Mannosyl-oligosaccharide glucosidase

# Metabolic_Enzyme_6_Synonyms:
Processing A- glucosidase I

# Metabolic_Enzyme_6_Gene_Name:
GCS1

# Metabolic_Enzyme_6_Protein_Sequence:
>Mannosyloligosaccharide glucosidase
MARGERRRRAVPAEGVRTAERAARGGPGRRDGRGGGPRSTAGGVALAVVVLSLALGMSGR
WVLAWYRARRAVTLHSAPPVLPADSSSPAVAPDLFWGTYRPHVYFGMKTRSPKPLLTGLM
WAQQGTTPGTPKLRHTCEQGDGVGPYGWEFHDGLSFGRQHIQDGALRLTTEFVKRPGGQH
GGDWSWRVTVEPQDSGTSALPLVSLFFYVVTDGKEVLLPEVGAKGQLKFISGHTSELGDF
RFTLLPPTSPGDTAPKYGSYNVFWTSNPGLPLLTEMVKSRLNSWFQHRPPGAPPERYLGL
PGSLKWEDRGPSGQGQGQFLIQQVTLKIPISIEFVFESGSAQAGGNQALPRLAGSLLTQA
LESHAEGFRERFEKTFQLKEKGLSSGEQVLGQAALSGLLGGIGYFYGQGLVLPDIGVEGS
EQKVDPALFPPVPLFTAVPSRSFFPRGFLWDEGFHQLVVQRWDPSLTREALGHWLGLLNA
DGWIGREQILGDEARARVPPEFLVQRAVHANPPTLLLPVAHMLEVGDPDDLAFLRKALPR
LHAWFSWLHQSQAGPLPLSYRWRGRDPALPTLLNPKTLPSGLDDYPRASHPSVTERHLDL
RCWVALGARVLTRLAEHLGEAEVAAELGPLAASLEAAESLDELHWAPELGVFADFGNHTK
AVQLKPRPPQGLVRVVGRPQPQLQYVDALGYVSLFPLLLRLLDPTSSRLGPLLDILADSR
HLWSPFGLRSLAASSSFYGQRNSEHDPPYWRGAVWLNVNYLALGALHHYGHLEGPHQARA
AKLHGELRANVVGNVWRQYQATGFLWEQYSDRDGRGMGCRPFHGWTSLVLLAMAEDY

# Metabolic_Enzyme_6_Number_of_Residues:
837

# Metabolic_Enzyme_6_Molecular_Weight:
91919

# Metabolic_Enzyme_6_Theoretical_pI:
9.18

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  glucosidase activity
Function:  mannosyl-oligosaccharide glucosidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  oligosaccharide metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner

# Metabolic_Enzyme_6_Pathway:
map00510  N-Glycan biosynthesis

# Metabolic_Enzyme_6_Reaction:
Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide Glc3Man9GlcNAc2

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF03200:Glyco_hydro_63

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
39-59

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.2.1.106

# Metabolic_Enzyme_6_GenBank_ID_Protein:
2344810

# Metabolic_Enzyme_6_SwissProt_ID:
GCS1_HUMAN (Q13724)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
Not Available

# Metabolic_Enzyme_6_Geneatlas_id:
Not Available

# Metabolic_Enzyme_6_hgnc_id:
Not Available

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass type II membrane protein

# Metabolic_Enzyme_6_Gene_Sequence:
>2511 bp
ATGGCTCGGGGCGAGCGGCGGCGCCGCGCAGTGCCGGCAGAGGGAGTGCGGACAGCCGAG
AGGGCGGCTCGGGGAGGCCCCGGGCGACGGGACGGCCGGGGCGGCGGGCCGCGTAGCACG
GCTGGAGGAGTGGCTCTGGCCGTCGTGGTCCTGTCTTTGGCCCTGGGTATGTCGGGGCGC
TGGGTGCTGGCGTGGTACCGTGCGCGGCGGGCGGTCACGCTGCACTCCGCGCCTCCTGTG
TTGCCTGCCGACTCCTCCAGCCCCGCCGTGGCCCCGGACCTCTTCTGGGGAACCTACCGC
CCTCACGTCTACTTCGGCATGAAGACCCGCAGCCCGAAACCCCTCCTCACCGGACTGATG
TGGGCGCAGCAGGGCACCACCCCGGGGACTCCTAAGCTCAGGCACACGTGTGAGCAGGGG
GACGGTGTGGGTCCCTATGGCTGGGAGTTCCACGACGGCCTCTCCTTCGGGCGCCAACAC
ATCCAGGATGGGGCCTTAAGGCTCACCACTGAGTTCGTCAAGAGGCCTGGGGGTCAGCAC
GGAGGGGACTGGAGCTGGAGAGTGACTGTAGAGCCTCAGGACTCAGGTACTTCTGCCCTC
CCTTTGGTCTCCCTGTTCTTCTATGTGGTGACAGATGGCAAGGAAGTCCTACTACCAGAG
GTTGGGGCCAAGGGGCAGTTGAAGTTTATCAGTGGGCACACCAGTCAACTTGGTAACTTC
CGCTTTACACTTTTGCCACCAACCAGTCCAGGGGATACAGCCCCCAAGTATGGCAGCTAC
AATGTCTTCTGGACCTCCAACCCAGGACTGCCCCTGCTGACAGAGATGGTAAAGAGTCGC
CTAAATAGCTGGTTTCAGCATCGGCCCCCAGGGGCCTCCCCTGAACGCTACCTCGGCTTG
CCAGGATCCCTGAAGTGGGAGGACAGAGGTCCAAGTGGGCAAGGGCAGGGGCAGTTCTTG
ATACAGCAGGTGACCCTGAAAATTCCATTTTCCATAGAGTTTGTGTTTGAATCAGGCAGT
GCCCAGGCAGGAGGAAATCAAGCCCTGCCAAGACTGGCAGGCAGTCTACTGACCCAGGCC
CTGGAGAGCCATGCTGAAGGCTTTAGAGAGCGCTTTGAGAAGACCTTCCAGCTGAAGGAG
AAGGGCCTGAGCTCTGGCGAGCAGGCTTTGGGTCAGGCTGCCCTCAGCGGCCTCCTTGGT
GGAATTGGCTACTTCTACGGACAAGGGCTGGTATTGCCAGACATCGGGGTGGAAGGGTCT
GAGCAGAAGGTGGACCCAGCCCTCTTTCCACCCGTACCTCTTTTTACAGCAGTGCCCTCC
CGGTCATTCTTCCCACGAGGCTTCCTTTGGGATGAAGGCTTTCACCAGCTGGTGGTTCAG
CGGTGGGATCCCTCCCTCACCCGGGAAGCCCTTGGCCACTGGCTGGGGCTGCTAAATGCT
GATGGCTGGATTGGGAGGGAGCAGATACTGGGGGATGAGGCCCGAGCCCGGGTGCCTCCA
GAATTCCTAGTACAACGAGCAGTCCACGCCAACCCCCCAACCCTACTTTTGCCTGTAGCC
CATATGCTAGAGGTTGGTGACCCTGACGACTTGGCTTTCCTCCGAAAGGCCTTGCCCCGC
CTGCATGCCTGGTTTTCCTGGCTCCATCAGAGCCAGGCAGGCCCACTGCCACTATCTTAC
CGCTGGCGGGGACGGGACCCTGCCTTACCAACCTTACTGAACCCCAAGACCCTACCCTCT
GGGCTGGATGACTACCCCCGGGCTTCACACCCTTCAGTAACCGAGCGGCACCTGGACCTG
CGATGTTGGGTGGGACTGGGTGCCCGTGTGCTGACGCGGCTGGCAGAGCATCTGGGTGAG
GCTGAGGTAGCTGCTGAGCTGGGCCCACTGGCTGCCTCACTGGAGGCAGCAGAGAGCCTG
GATGAGCTGCACTGGGCCCCAGAGCTAGGAGTCTTTGCAGACTTTGGGAACCACACAAAA
GCAGTACAGCTGAAGCCCAGGCCCCCTCAGGGGCTCGTTCGGGTGGTGGGTCGGCCCCAA
CCTCAACTGCAGTATGTAGATGCTCTTGGCTATGTCAGTCTTTTTCCCTTGCTGCTGCGA
CTGCTGGACCCCACCTCATCCCGCCTTGGGCCCCTGCTGGACATTCTAGCCGACAGCCGC
CATCTCTGGAGCCCCTTTGGTTTACGCTCCCTTGCAGCCTCCAGCTCCTTTTATGGCCAG
CGCAATTCAGAGCATGATCCCCCCTACTGGCGGGGTGCTGTGTGGCTCAATGTCAACTAC
CTGGCTTTGGGAGCACTCCACCACTATGGGCATCTGGAGGGTCCTCACCAGGCTCGGGCT
GCCAAACTCCACGGTGAGCTCCGTGCCAACGTGGTAGGCAATGTATGGCGCCAGTACCAG
GCCACAGGCTTTCTTTGGGAGCAGTACAGTGACCGCGATGGGCGAGGCATGTGCCGCCCT
TTCCACGGCTGGACCAGCCTTGTCTTACTGGCCATGGCTGAAGACTACTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
X87237

# Metabolic_Enzyme_6_Chromosome_Location:
Not Available

# Metabolic_Enzyme_6_Locus:
Not Available

# Metabolic_Enzyme_6_SNPs:
Not Available

# Metabolic_Enzyme_6_General_References:
7635146

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5605

# Metabolic_Enzyme_7_Name:
ADP-dependent glucokinase

# Metabolic_Enzyme_7_Synonyms:
ADPGK; ADP-GK; RbBP-35

# Metabolic_Enzyme_7_Gene_Name:
ADPGK

# Metabolic_Enzyme_7_Protein_Sequence:
>ADPdependent glucokinase
MALWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPPGPVSPEGRLAAA
WDALIVRPVRRWRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSILHSRNDLEEAFI
HFMGKGAAAERFFSDKETFHDIAQVASEFPGAQHYVGGNAALIGQKFAANSDLKVLLCGP
VGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWGQLKAPHANRFIFSHDLSNGAM
NMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVVTSISDIPTGIPVHLELAS
MTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLSSWNGVPDVGMVSDILF
WILKEHGRSKSRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETI
DTSRVSLRAPQEFMTSHSEAGSRIVLNPNKPVVEWHREGISFHFTPVLVCKDPIRTVGLG
DAISAEGLFYSEVHPHY

# Metabolic_Enzyme_7_Number_of_Residues:
497

# Metabolic_Enzyme_7_Molecular_Weight:
54089

# Metabolic_Enzyme_7_Theoretical_pI:
6.17

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
 ||
>>>
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
ADP + D-glucose = AMP + D-glucose 6-phosphate

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF04587:ADP_PFK_GK

# Metabolic_Enzyme_7_Signals:
1-22

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.7.1.147

# Metabolic_Enzyme_7_GenBank_ID_Protein:
16923351

# Metabolic_Enzyme_7_SwissProt_ID:
ADPGK_HUMAN (Q9BRR6)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
ADPGK

# Metabolic_Enzyme_7_Geneatlas_id:
ADPGK

# Metabolic_Enzyme_7_hgnc_id:
HGNC:25250

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>1044 bp
ATGGGGAAGGGAGCAGCTGCTGAGCGCTTCTTCAGTGATAAGGAAACTTTTCACGACATT
GCCCAGGTTGCGTCAGAGTTCCCAGGAGCCCAGCACTATGTAGGAGGAAATGCAGCTTTA
ATTGGACAGAAATTTGCAGCCAACTCAGATTTAAAGGTTCTTCTTTGCGGTCCAGTTGGT
CCAAAGCTACATGAGCTTCTTGATGACAATGTCTTTGTTCCACCAGAGTCATTGCAGGAA
GTGGATGAGTTCCACCTCATTTTAGAGTATCAAGCAGGGGAGGAGTGGGGCCAGTTAAAA
GCTCCCCATGCCAACCGATTCATCTTCTCTCACGACCTCTCCAACGGGGCCATGAATATG
CTGGAGGTGTTTGTGTCTAGCCTGGAGGAGTTTCAGCCAGACCTGGTGGTCCTCTCTGGA
TTGCACATGATGGAGGGACAAAGCAAGGAGCTCCAGAGGAAGAGACTCTTGGAGGTTGTA
ACCTCCATTTCTGACATCCCCACTGGTATTCCAGTTCACCTAGAGCTGGCCAGTATGACT
AACAGGGAGCTCATGAGCAGCATTGTCCATCAGCAGGTCTTTCCCGCGGTGACTTCCCTT
GGGCTGAATGAACAGGAGCTGTTATTTCTCACCCAGTCAGCCTCTGGACCTCACTCTTCT
CTCTCTTCCTGGAACGGTGTTCCTGATGTGGGCATGGTCAGTGACATCCTCTTCTGGATC
TTGAAAGAACATGGGAGGAGTAAAAGCAGAGCCTCGGATCTCACCAGGATCCATTTCCAC
ACGCTGGTCTACCACATCCTGGCAACTGTGGATGGACACTGGGCCAACCAGCTGGCAGCC
GTGTTAGGAAGCTCGTGTGGCTGGGACACAGGCCTGCGCCACAGAAACCATAGACACCAG
CCGAGTGTCTCTGAGGGCACCCCAAGAGTTCATGACTTCCCATTCGGAGGCAGGCTCCAG
GATTGTATTAAACCCAAACAAGCCAGTAGTAGAATGGCACAGAGAGGGAATATCCTTCCA
CTTCACACCAGTATTGGTGTGTAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AF204270

# Metabolic_Enzyme_7_Chromosome_Location:
Not Available

# Metabolic_Enzyme_7_Locus:
Not Available

# Metabolic_Enzyme_7_SNPs:
Not Available

# Metabolic_Enzyme_7_General_References:
11230166

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5606

# Metabolic_Enzyme_8_Name:
Glycogen phosphorylase, liver form

# Metabolic_Enzyme_8_Synonyms:
Not Available

# Metabolic_Enzyme_8_Gene_Name:
PYGL

# Metabolic_Enzyme_8_Protein_Sequence:
>Glycogen phosphorylase, liver form
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTV
RDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEA
DDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN
TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL
PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP
KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF
QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQ
ENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV
PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPA
TDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA
ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA
YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE
SNKVNGN

# Metabolic_Enzyme_8_Number_of_Residues:
847

# Metabolic_Enzyme_8_Molecular_Weight:
97150

# Metabolic_Enzyme_8_Theoretical_pI:
7.17

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
Function:  phosphorylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

# Metabolic_Enzyme_8_Pathway:
map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_8_Reaction:
(1,4-alpha-D-glucosyl)n + phosphate = (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00343:Phosphorylase

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.4.1.1

# Metabolic_Enzyme_8_GenBank_ID_Protein:
183353

# Metabolic_Enzyme_8_SwissProt_ID:
PYGL_HUMAN (P06737)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
PYGL

# Metabolic_Enzyme_8_Geneatlas_id:
PYGL

# Metabolic_Enzyme_8_hgnc_id:
HGNC:9725

# Metabolic_Enzyme_8_PDB_ID:
1L7X

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Not Available

# Metabolic_Enzyme_8_Gene_Sequence:
>2544 bp
ATGGGCGAACCGCTGACAGACCAGGAGAAGCGGCGGCAGATCAGCATCCGCGGCATCGTG
GGCGTGGAGAACGTGGCAGAGCTGAAGAAGAGTTTCAACCGGCACCTGCACTTCACGCTG
GTCAAGGACCGCAACGTGGCCACCACCCGCGACTACTACTTCGCGCTGGCGCACACGGTG
CGGGACCACCTGGTGGGGCGCTGGATCCGCACGCAGCAGCACTACTACGACAAGTGCCCC
AAGAGGGAATATTACCTCTCTCTGGAATTTTACATGGGCCGAACATTACAGAACACCATG
ATCAACCTCGGTCTGCAAAATGCCTGTGATGAGGCCATTTACCAGCTTGGATTGGATATA
GAAGAGTTAGAAGAAATTGAAGAAGATGCTGGACTTGGCAATGGTGGTCTTGGGAGACTT
GCTGCCTGCTTCTTGGATTCCATGGCAACCCTGGGACTTGCAGCCTATGGATACGGCATT
CGGTATGAATATGGGATTTTCAATCAGAAGATCCGAGATGGATGGCAGGTAGAAGAAGCA
GATGATTGGCTCAGATATGGAAACCCTTGGGAGAAGTCCCGCCCAGAATTCATGCTGCCT
GTGCACTTCTATGGAAAAGTAGAACACACCAACACCGGGACCAAGTGGATTGACACTCAA
GTGGTCCTGGCTCTGCCATATGACACCCCCGAGCCCGGCTACATGAATAACACTGTCAAC
ACCATGCGCCTCTGGTCTGCTCGGGCACCAAATGACTTTAACCTCAGAGACTTTAATGTT
GGAGACTACATTCAGGCTGTGCTGGACCGAAACCTGGCCGAGAACATCTCCCGGGTCCTC
TATCCCAATGACAATTTTTTTGAAGGGAAGGAGCTAAGATTGAAGCAGGAATACTTTGTG
GTGGCTGCAACCTTGCAAGATATCATCCGCCGTTTCAAAGCCTCCAAGTTTGGCTCCACC
CGTGGTCAAGGAACTGTGTTTGATGCCTTCCCGGATCAGGTGGCCATCCAGCTGAATGAT
ACTCACCCTCGCATCGCGATCCCTGAGCTGATGAGGATTTTTGTGGATATTGAAAAACTG
CCCTGGTCCAAGGCATGGGAGCTCAACCAGAAGACCTTCGCCTACACCAACCACACAGTG
CTCCCGGAAGCCCTGGAGCGCTGGCCCGTGGACCTGGTGGAGAAGCTGCTCCCTCGACAT
TTGGAAATCATTTATGAGATAAATCAGAAGCATTTAGATAGAATTGTGGCCTTGTTTCCT
AAAGATGTGGACCCTCTGAGAAGGATGTCTCTGATAGAAGAGGAAGGAAGCAAAAGGATC
AACATGGCCCATCTCTGCATTGTCGGTTCCCATGCTGTGAATGGCGTGGCTAAAATCCAC
TCAGACATCGTGAAGACTAAAGTATTCAAGGACTTCAGTGAGCTAGAACCTGACAAGTTT
CAGAATAAAACCAATGGGATCACTCCAAGGCGCTGGCTCCTACTCTGCAACCCAGGACTT
GCAGAGCTCATAGCAGAGAAAATTGGAGAAGACTATGTGAAAGACCTGAGCCAGCTGACG
AAGCTCCACAGCTTCCTGGGTGATGATGTCTTCCTCCGGGAACTCGCCAAGGTGAAGCAG
GAGAATAAGCTGAAGTTTTCTCAGTTCCTGGAGACGGAGTACAAAGTGAAGATCAACCCA
TCCTCCATGTTTGATGTCCAGGTGAAGAGGATACATGAGTACAAGCGACAGCTCTTGAAC
TGTCTGCATGTGATCACGATGTACAACCGCATTAAGAAAGACCCTAAGAAGTTATTCGTG
CCAAGGACAGTTATCATTGGTGGTAAAGCTGCCCCAGGATATCACATGGCCAAAATGATC
ATAAAGCTGATCACTTCAGTGGCAGATGTGGTGAACAATGACCCTATGGTTGGAAGCAAG
TTGAAAGTCATCTTCTTGGAGAACTACAGAGTATCTCTTGCTGAAAAAGTCATTCCAGCC
ACAGATCTGTCAGAGCAGATTTCCACTGCAGGCACCGAAGCCTCGGGGACAGGCAATATG
AAGTTCATGCTAAATGGGGCCCTAACTATCGGGACCATGGATGGGGCCAATGTGGAAATG
GCAGAAGAAGCTGGGGAAGAGAACCTGTTCATCTTTGGCATGAGCATAGATGATGTGGCT
GCTTTGGACAAGAAAGGGTACGAGGCAAAAGAATACTATGAGGCACTTCCAGAGCTGAAG
CTGGTCATTGATCAAATTGACAATGGCTTTTTTTCTCCCAAGCAGCCTGACCTCTTCAAA
GATATCATCAACATGCTATTTTATCATGACAGGTTTAAAGTCTTTGCAGACTACGAAGCC
TATGTCAAGTGTCAAGATAAAGTGAGTCAGCTGTACATGAATCCAAAGGCCTGGAACACA
ATGGTACTCAAAAACATAGCTGCCTCGGGGAAATTCTCCAGTGACCGAACAATTAAAGAA
TATGCCCAAAACATCTGGAACGTGGAACCTTCAGATCTAAAGATTTCTCTATCCAATGAA
TCTAACAAAGTCAATGGAAATTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
M14636

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_8_Locus:
14q21-q22

# Metabolic_Enzyme_8_SNPs:
rs946616; rs2228499; rs35831273; rs34313873; rs2275465; rs17123244; rs1042193; rs2027342; rs2277456; rs1959527; rs2356729; rs1890706; rs1953875; rs946618; rs946617; rs1890705; rs883699; rs1890707; rs8004768; rs10143053; rs11157783; rs2275464; rs6572712; rs7160537; rs2075646; rs6572710; rs10132049; rs3825542; rs11852047; rs3783275; rs11846565; rs8021270; rs11846180; rs8022952; rs2027341; rs1953872; rs10149867; rs11851644; rs3783273; rs3825541; rs2356535; rs3783274; rs8004788; rs11851482; rs17123189; rs11851115; rs8014291; rs2275466; rs7142143; rs12432519; rs11845307; rs7149936; rs17123178; rs1953873; rs10138493; rs10140858; rs3818871; rs8005400; rs17123235; rs11844515; rs11850411; rs3783276; rs7154048; rs8019788; rs12436081; rs12717412; rs10146041; rs8003312; rs8003460; rs882860; rs8022363; rs17123173; rs9635167; rs6572711; rs17123125; rs10142003; rs17123232; rs8005931; rs4901066; rs11845548; rs11623430; rs12878997; rs8008832; rs17123223; rs8006455; rs8019957; rs17123216; rs17123180; rs8020787; rs17123242; rs3783277; rs8019817; rs11849348; rs11851406; rs8009460; rs8019779; rs11846533; rs11850468; rs10130689; rs8020100; rs9635221; rs12887698; rs2297890; rs7159436; rs3759524; rs2297891; rs8005560; rs7159221; rs1126549; rs35026927; rs34096980; rs11541446; rs1042210; rs1042195; rs17721570; rs35110875; rs1042191; rs11356035; rs8018727; rs10539449; rs11420723; rs35650221; rs28419360; rs34660650; rs34764341; rs35154208; rs5808582; rs33962723; rs7157107; rs36014565; rs8021856; rs3837582; rs10140029; rs34040095; rs28584430; rs10146475; rs5808583; rs34267914; rs35765728; rs4540982; rs11849168; rs12888774; rs12881770; rs12882746; rs8006359; rs9788547; rs17123214; rs8009028; rs34052455; rs35565564; rs35049468; rs35657235; rs17123129; rs34648049; rs3783278; rs5808581; rs10145332; rs35116945; rs17123212; rs28497027; rs11308384; rs4027576; rs12882737; rs35955629; rs35236069; rs34707370; rs11351672; rs12887874; rs35638781; rs17123170; rs11414268; rs12881559; rs10674203; rs34456437; rs10133328; rs1890701; rs12882740; rs41317304; rs33993827; rs11846857; rs8005878; rs35069435; rs35098001; rs7141901; rs3082637; rs35620941; rs35195741; rs8016466; rs17123239; rs12882739; rs12879826; rs4898677; rs28540603; rs34592047; rs34351109; rs28407049; rs28707425; rs12880288; rs28759343; rs1005689; rs1042266; rs11157780; rs11157781; rs11157782; rs11847031; rs11847533; rs11850729; rs11850781; rs12431674; rs12431737; rs12434792; rs12589201; rs12589665; rs12880129; rs12889552; rs12891106; rs1538615; rs17123097; rs17123103; rs17123116; rs1890700; rs1890704; rs2075643; rs2075644; rs2075645; rs2185303; rs2356730; rs28564871; rs34204001; rs34240348; rs34800262; rs35501326; rs3759519; rs3759520; rs3759521; rs4901064; rs4901065; rs4901067; rs7154732; rs7159068; rs885375

# Metabolic_Enzyme_8_General_References:
2877458; 9536091; 9529348; 3509980; 10980448; 10949035; 12204691

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5442

# Metabolic_Enzyme_9_Name:
Glucokinase

# Metabolic_Enzyme_9_Synonyms:
Hexokinase-4; Hexokinase type IV; HK IV; HK4; Hexokinase-D

# Metabolic_Enzyme_9_Gene_Name:
GCK

# Metabolic_Enzyme_9_Protein_Sequence:
>Glucokinase
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ

# Metabolic_Enzyme_9_Number_of_Residues:
465

# Metabolic_Enzyme_9_Molecular_Weight:
52192

# Metabolic_Enzyme_9_Theoretical_pI:
4.85

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage

# Metabolic_Enzyme_9_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism;
 map00521  Streptomycin biosynthesis

# Metabolic_Enzyme_9_Reaction:
ATP + D-glucose = ADP + D-glucose 6-phosphate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00349:Hexokinase_1;
PF03727:Hexokinase_2

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.7.1.2

# Metabolic_Enzyme_9_GenBank_ID_Protein:
179427

# Metabolic_Enzyme_9_SwissProt_ID:
HXK4_HUMAN (P35557)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
GCK

# Metabolic_Enzyme_9_Geneatlas_id:
GCK

# Metabolic_Enzyme_9_hgnc_id:
HGNC:4195

# Metabolic_Enzyme_9_PDB_ID:
1V4T

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Not Available

# Metabolic_Enzyme_9_Gene_Sequence:
>1398 bp
ATGCTGGACGACAGAGCCAGGATGGAGGCCGCCAAGAAGGAGAAGGTAGAGCAGATCCTG
GCAGAGTTCCAGCTGCAGGAGGAGGACCTGAAGAAGGTGATGAGACGGATGCAGAAGGAG
ATGGACCGCGGCCTGAGGCTGGAGACCCATGAAGAGGCCAGTGTGAAGATGCTGCCCACC
TACGTGCGCTCCACCCCAGAAGGCTCAGAAGTCGGGGACTTCCTCTCCCTGGACCTGGGT
GGCACTAACTTCAGGGTGATGCTGGTGAAGGTGGGAGAAGGTGAGGAGGGGCAGTGGAGC
GTGAAGACCAAACACCAGATGTACTCCATCCCCGAGGACGCCATGACCGGCACTGCTGAG
ATGCTCTTCGACTACATCTCTGAGTGCATCTCCGACTTCCTGGACAAGCATCAGATGAAA
CACAAGAAGCTGCCCCTGGGCTTCACCTTCTCCTTTCCTGTGAGGCACGAAGACATCGAT
AAGGGCATCCTTCTCAACTGGACCAAGGGCTTCAAGGCCTCAGGAGCAGAAGGGAACAAT
GTCGTGGGGCTTCTGCGAGACGCTATCAAACGGAGAGGGGACTTTGAAATGGATGTGGTG
GCAATGGTGAATGACACGGTGGCCACGATGATCTCCTGCTACTACGAAGACCATCAGTGC
GAGGTCGGCATGATCGTGGGCACGGGCTGCAATGCCTGCTACATGGAGGAGATGCAGAAT
GTGGAGCTGGTGGAGGGGGACGAGGGCCGCATGTGCGTCAATACCGAGTGGGGCGCCTTC
GGGGACTCCGGCGAGCTGGACGAGTTCCTGCTGGAGTATGACCGCCTGGTGGACGAGAGC
TCTGCAAACCCCGGTCAGCAGCTGTATGAGAAGCTCATAGGTGGCAAGTACATGGGCGAG
CTGGTGCGGCTTGTGCTGCTCAGGCTCGTGGACGAAAACCTGCTCTTCCACGGGGAGGCC
TCCGAGCAGCTGCGCACACGCGGAGCCTTCGAGACGCGCTTCGTGTCGCAGGTGGAGAGC
GACACGGGCGACCGCAAGCAGATCTACAACATCCTGAGCACGCTGGGGCTGCGACCCTCG
ACCACCGACTGCGACATCGTGCGCCGCGCCTGCGAGAGCGTGTCTACGCGCGCTGCGCAC
ATGTGCTCGGCGGGGCTGGCGGGCGTCATCAACCGCATGCGCGAGAGCCGCAGCGAGGAC
GTAATGCGCATCACTGTGGGCGTGGATGGCTCCGTGTACAAGCTGCACCCCAGCTTCAAG
GAGCGGTTCCATGCCAGCGTGCGCAGGCTGACGCCCAGCTGCGAGATCACCTTCATCGAG
TCGGAGGAGGGCAGTGGCCGGGGCGCGGCCCTGGTCTCGGCGGTGGCCTGTAAGAAGGCC
TGTATGCTGGGCCAGTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
M88011

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_9_Locus:
7p15.3-p15.1

# Metabolic_Enzyme_9_SNPs:
rs2908275; rs2908276; rs13306390; rs13306391; rs2284776; rs2268572; rs2908290; rs741038; rs758989; rs2908289; rs2070971; rs2908296; rs758985; rs2268576; rs2268574; rs2300586; rs1990458; rs2908297; rs1303722; rs3808319; rs2300584; rs2971672; rs2284777; rs12540369; rs2268575; rs2908298; rs2010825; rs12535229; rs7793213; rs2908292; rs2971677; rs3808323; rs12534623; rs2971679; rs2268570; rs2908274; rs730497; rs11766576; rs3808322; rs12673242; rs2971678; rs17832252; rs2268573; rs2971674; rs2971671; rs4724290; rs2041547; rs758987; rs13239289; rs2268569; rs3808320; rs17172566; rs10246064; rs758988; rs16881016; rs2300587; rs3808321; rs887688; rs2284773; rs758986; rs887686; rs2244164; rs10259649; rs12702069; rs2284769; rs6952751; rs11768239; rs2080033; rs2971676; rs887687; rs2971675; rs2908293; rs6945550; rs13306387; rs2908291; rs12702068; rs12534104; rs2215644; rs1799884; rs1476891; rs2908277; rs12702070; rs34389297; rs13306389; rs35548117; rs34322372; rs13306388; rs13306393; rs41282709; rs35140467; rs13306392; rs35521280; rs34255297; rs28639899; rs741039; rs5883891; rs2284771; rs34710012; rs34691097; rs2971670; rs34288160; rs34574619; rs34807880; rs3216596; rs34265547; rs34672149; rs34973571; rs35368425; rs13227198; rs36094778; rs35276355; rs28491181; rs34859037; rs34947625; rs5883890; rs35079658; rs34780996; rs35606092; rs34124036; rs2971680; rs3065183; rs41282712; rs35786405; rs4724291; rs3840676; rs34675661; rs2284778; rs11447509; rs2284779; rs2268577; rs10680351; rs1303721; rs2908294; rs34114506; rs1799831; rs36084943; rs2908295; rs11974018; rs34380942; rs36118223; rs35568119; rs2284772; rs34185745; rs11772934; rs35262363; rs11412934; rs35723429; rs2284774; rs41282715; rs36193808; rs11287012; rs6971410; rs41314139; rs2284775; rs35688609; rs13239987; rs34178750; rs28684786; rs35620913; rs35907141; rs34976798; rs34359315; rs3779606; rs13306394; rs3840677; rs1076439; rs36205687; rs35670475; rs11372006; rs36205684; rs2971681; rs36205686; rs36205690; rs36205688; rs1008384; rs12669054; rs17135975; rs17136076; rs17172591; rs17769733; rs2080032; rs2908278; rs2908286; rs2971669; rs3757838; rs3757840; rs4397301; rs4607517; rs6953355; rs6975024; rs735670; rs737525; rs741033; rs741034; rs741035; rs741036; rs741037; rs758983; rs882019; rs882020; rs882021

# Metabolic_Enzyme_9_General_References:
1354840; 1871135; 1511800; 1612194; 1502186; 1464666; 8194664; 1303265; 8454109; 8495817; 8325892; 8446612; 8168652; 9049484; 9662401; 9435328; 10588527; 11106831; 11372010

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5607

# Metabolic_Enzyme_10_Name:
Beta-1,4-galactosyltransferase 2

# Metabolic_Enzyme_10_Synonyms:
Beta-1,4-GalTase 2; Beta4Gal-T2; b4Gal-T2; UDP-galactose:beta-N-acetylglucosamine beta- 1,4-galactosyltransferase 2; UDP-Gal:beta-GlcNAc beta-1,4- galactosyltransferase 2[Includes: Lactose synthase A protein; Nal synthetase; Beta-N-acetylglucosaminylglycopeptide beta-1,4- galactosyltransferase

# Metabolic_Enzyme_10_Gene_Name:
B4GALT2

# Metabolic_Enzyme_10_Protein_Sequence:
>Beta1,4galactosyltransferase 2
MSRLLGGTLERVCKAVLLLCLLHFLVAVILYFDVYAQHLAFFSRFSARGPAHALHPAASS
SSSSSNCSRPNATASSSGLPEVPSALPGPTAPTLPPCPDSPPGLVGRLLIEFTSPMPLER
VQRENPGVLMGGRYTPPDCTPAQTVAVIIPFRHREHHLRYWLHYLHPILRRQRLRYGVYV
INQHGEDTFNRAKLLNVGFLEALKEDAAYDCFIFSDVDLVPMDDRNLYRCGDQPRHFAIA
MDKFGFRLPYAGYFGGVSGLSKAQFLRINGFPNEYWGWGGEDDDIFNRISLTGMKISRPD
IRIGRYRMIKHDRDKHNEPNPQRFTKIQNTKLTMKRDGIGSVRYQVLEVSRQPLFTNITV
DIGRPPSWPPRG

# Metabolic_Enzyme_10_Number_of_Residues:
372

# Metabolic_Enzyme_10_Molecular_Weight:
41973

# Metabolic_Enzyme_10_Theoretical_pI:
9.66

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Not Available

# Metabolic_Enzyme_10_Specific_Function:
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose

# Metabolic_Enzyme_10_Pathway:
map00510  N-Glycan biosynthesis;
 map00533  Keratan sulfate biosynthesis

# Metabolic_Enzyme_10_Reaction:
UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF02709:Galactosyl_T_2

# Metabolic_Enzyme_10_Signals:
1-27

# Metabolic_Enzyme_10_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.4.1.22;EC 2.4.1.90;E

# Metabolic_Enzyme_10_GenBank_ID_Protein:
2995442

# Metabolic_Enzyme_10_SwissProt_ID:
B4GT2_HUMAN (O60909)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
B4GALT2

# Metabolic_Enzyme_10_Geneatlas_id:
B4GALT2

# Metabolic_Enzyme_10_hgnc_id:
HGNC:925

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Golgi apparatus; Golgi stack; Golgi stack membrane; single-pass type II membrane protein. Note=Trans cisternae of Golgi stack

# Metabolic_Enzyme_10_Gene_Sequence:
>1119 bp
ATGAGCAGACTGCTGGGGGGGACGCTGGAGCGCGTCTGCAAGGCTGTGCTCCTTCTCTGC
CTGCTGCACTTCCTCGTGGCCGTCATCCTCTACTTTGACGTCTACGCCCAGCACCTGGCC
TTCTTCAGCCGCTTCAGTGCCCGAGGCCCTGCCCATGCCCTCCACCCAGCTGCTAGCAGC
AGCAGCAGCAGCAGCAACTGCTCCCGGCCCAACGCCACCGCCTCTAGCTCCGGGCTCCCT
GAGGTCCCCAGTGCCCTGCCCGGTCCCACGGCTCCCACGCTGCCACCCTGTCCTGACTCG
CCACCTGGTCTTGTGGGCAGACTGCTGATCGAGTTCACCTCACCCATGCCCCTGGAGCGG
GTGCAGAGGGAGAACCCAGGCGTGCTCATGGGCGGCCGATACACACCGCCCGACTGCACC
CCAGCCCAGACGGTGGCGGTCATCATCCCCTTTAGACACCGGGAACACCACCTGCGCTAC
TGGCTCCACTATCTACACCCCATCTTGAGGCGGCAGCGGCTGCGCTACGGCGTCTATGTC
ATCAACCAGCATGGTGAGGACACCTTCAACCGGGCCAAGCTGCTTAACGTGGGCTTCCTA
GAGGCGCTGAAGGAGGATGCCGCCTATGACTGCTTCATCTTCAGCGATGTGGACCTGGTC
CCCATGGATGACCGCAACCTATACCGCTGCGGCGACCAACCCCGCCACTTTGCCATTGCC
ATGGACAAGTTTGGCTTCCGGCTTCCCTATGCTGGCTACTTTGGAGGTGTGTCAGGCCTG
AGTAAGGCTCAGTTTCTGAGAATCAATGGCTTCCCCAATGAGTACTGGGGCTGGGGTGGC
GAGGATGATGACATCTTCAACCGGATCTCCCTGACTGGGATGAAGATCTCACGCCCAGAC
ATCCGAATCGGCCGCTACCGCATGATCAAGCACGACCGCGACAAGCATAACGAACCTAAC
CCTCAGAGGTTTACCAAGATTCAAAACACGAAGCTGACCATGAAGCGGGACGGCATTGGG
TCAGTGCGGTACCAGGTCTTGGAGGTGTCTCGGCAACCACTCTTCACCAATATCACAGTG
GACATTGGGCGGCCTCCGTCGTGGCCCCCTCGGGGCTGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
Y12510

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_10_Locus:
1p34-p33

# Metabolic_Enzyme_10_SNPs:
rs1859728; rs1061781; rs2486005; rs2231280; rs2486006; rs2486003; rs869896; rs2231283; rs11577031; rs12738136; rs2286244; rs11577574; rs4567315; rs3791122; rs882961; rs11544735; rs2353008; rs1061780; rs41303407; rs11544734; rs35324782; rs3762423; rs12752663; rs2231281; rs2231279; rs2993619; rs730915; rs2486004; rs34803765; rs28578348; rs2231282; rs34161254; rs34309153; rs28379629; rs12031636; rs34951027; rs730916; rs35671171; rs34690835; rs34640774; rs12030702; rs41270399; rs13374291; rs34413382; rs11804947; rs11580847; rs12410334; rs12563522; rs12757070; rs1296541; rs14084; rs14785; rs16831527; rs2231285; rs2248253; rs2248632; rs2286241; rs2286242; rs2286243; rs2286245; rs2286246; rs2301983; rs2428953; rs2428954; rs2486008; rs35181336; rs35286676; rs35655174; rs35904809; rs36042542; rs3791124; rs3791125; rs4660761; rs6671811; rs7161; rs7528392; rs7555; rs783308; rs803619; rs8494

# Metabolic_Enzyme_10_General_References:
9405390; 9597550; 11588157; 10580128

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5608

# Metabolic_Enzyme_11_Name:
Alpha-lactalbumin precursor

# Metabolic_Enzyme_11_Synonyms:
Lactose synthase B protein; Lysozyme- like protein 7

# Metabolic_Enzyme_11_Gene_Name:
LALBA

# Metabolic_Enzyme_11_Protein_Sequence:
>Alphalactalbumin precursor
MRFFVPLFLVGILFPAILAKQFTKCELSQLLKDIDGYGGIALPELICTMFHTSGYDTQAI
VENNESTEYGLFQISNKLWCKSSQVPQSRNICDISCDKFLDDDITDDIMCAKKILDIKGI
DYWLAHKALCTEKLEQWLCEKL

# Metabolic_Enzyme_11_Number_of_Residues:
142

# Metabolic_Enzyme_11_Molecular_Weight:
16225

# Metabolic_Enzyme_11_Theoretical_pI:
4.60

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  UDP-glycosyltransferase activity
Function:  UDP-galactosyltransferase activity
Function:  lactose synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  cellular carbohydrate metabolism
Process:  disaccharide metabolism
Process:  lactose metabolism
Process:  lactose biosynthesis
 ||
>>>
Component:  extracellular region

# Metabolic_Enzyme_11_General_Function:
Not Available

# Metabolic_Enzyme_11_Specific_Function:
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins

# Metabolic_Enzyme_11_Pathway:
Not Available

# Metabolic_Enzyme_11_Reaction:
Not Available

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00062:Lys

# Metabolic_Enzyme_11_Signals:
1-19

# Metabolic_Enzyme_11_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.4.1.22

# Metabolic_Enzyme_11_GenBank_ID_Protein:
307104

# Metabolic_Enzyme_11_SwissProt_ID:
LALBA_HUMAN (P00709)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
LALBA

# Metabolic_Enzyme_11_Geneatlas_id:
LALBA

# Metabolic_Enzyme_11_hgnc_id:
HGNC:6480

# Metabolic_Enzyme_11_PDB_ID:
1HML

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_11_Gene_Sequence:
>429 bp
ATGAGGTTCTTTGTCCCTCTGTTCCTGGTGGGCATCCTGTTCCCTGCCATCCTGGCCAAG
CAATTCACAAAATGTGAGCTGTCCCAGCTGCTGAAAGACATAGATGGTTATGGAGGCATC
GCTTTGCCTGAATTGATCTGTACCATGTTTCACACCAGTGGTTATGACACACAAGCCATA
GTTGAAAACAATGAAAGCACGGAATATGGACTCTTCCAGATCAGTAATAAGCTTTGGTGC
AAGAGCAGCCAGGTCCCTCAGTCAAGGAACATCTGTGACATCTCCTGTGACAAGTTCCTG
GATGATGACATTACTGATGACATAATGTGTGCCAAGAAGATCCTGGATATTAAAGGAATT
GACTACTGGTTGGCCCATAAAGCCCTCTGCACTGAGAAGCTGGAACAGTGGCTTTGTGAG
AAGTTGTGA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
J00270

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_11_Locus:
12q13

# Metabolic_Enzyme_11_SNPs:
rs2232565; rs2232566; rs2071380; rs2232569; rs2232570; rs2731088; rs2705170; rs2409044; rs12582811; rs11168643; rs11168642; rs3759149; rs10875835; rs4439559; rs2232567; rs2232568; rs35237195; rs34192861; rs10696670; rs34861458; rs12372110; rs7315024; rs35399476; rs35014829; rs10747550; rs10875833; rs10875834; rs11168635; rs11168636; rs11168637; rs11168638; rs11168639; rs11168640; rs11168641; rs11168644; rs12317119; rs12580814; rs17237094; rs17237198; rs17834022; rs1807757; rs1863543; rs1895997; rs1895998; rs1895999; rs2114321; rs2114322; rs2162318; rs2194984; rs2555002; rs2555003; rs2705117; rs7306166; rs7312017

# Metabolic_Enzyme_11_General_References:
6285305; 2954544; 5049057; 1920433; 8366079; 9537992; 10080897

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5610

# Metabolic_Enzyme_12_Name:
Glycogen phosphorylase, muscle form

# Metabolic_Enzyme_12_Synonyms:
Myophosphorylase

# Metabolic_Enzyme_12_Gene_Name:
PYGM

# Metabolic_Enzyme_12_Protein_Sequence:
>Glycogen phosphorylase, muscle form
MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTV
RDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDM
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEA
DDWLRYGNPWEKARPEFTLPVHFYGHVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVN
TMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERM
DWDKAWDVTVRTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFP
GDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKF
QNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLDQLRKLLSFVDDEAFIRDVAKVKQ
ENKLKFAAYLEREYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKREPNKFFV
PRTVMIGGKAAPGYHMAKMIIRLVTAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPA
ADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVD
KLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYED
YIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE
AI

# Metabolic_Enzyme_12_Number_of_Residues:
842

# Metabolic_Enzyme_12_Molecular_Weight:
97093

# Metabolic_Enzyme_12_Theoretical_pI:
7.03

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
Function:  phosphorylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_12_Specific_Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

# Metabolic_Enzyme_12_Pathway:
map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_12_Reaction:
(1,4-alpha-D-glucosyl)n + phosphate = (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00343:Phosphorylase

# Metabolic_Enzyme_12_Signals:
None

# Metabolic_Enzyme_12_Transmembrane_Regions:
None

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 2.4.1.1

# Metabolic_Enzyme_12_GenBank_ID_Protein:
190784

# Metabolic_Enzyme_12_SwissProt_ID:
PYGM_HUMAN (P11217)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
PYGM

# Metabolic_Enzyme_12_Geneatlas_id:
PYGM

# Metabolic_Enzyme_12_hgnc_id:
HGNC:9726

# Metabolic_Enzyme_12_PDB_ID:
1XL1

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Not Available

# Metabolic_Enzyme_12_Gene_Sequence:
>2529 bp
ATGTCCCGGCCCCTGTCAGACCAAGAGAAAAGAAAGCAAATCAGTGTGCGTGGCCTGGCC
GGCGTGGAGAACGTGACTGAGCTGAAAAAGAACTTCAACCGGCACCTGCATTTCACACTC
GTAAAGGACCGCAATGTGGCCACCCCACGAGACTACTACTTTGCTCTGGCCCATACCGTG
CGCGACCACCTCGTGGGGCGGTGGATCCGCACGCAGCAGCACTACTATGAGAAGGACCCC
AAGAGGATCTACTACCTGTCTTTAGAGTTCTATATGGGACGGACGCTACAGAACACCATG
GTGAACCTGGCCTTAGAGAATGCCTGTGACGAGGCCACCTACCAGCTGGGCCTGGACATG
GAGGAGCTGGAGGAAATTGAGGAGGATGCGGGGCTGGGCAACGGGGGCCTGGGCCGGCTG
GCAGCCTGCTTTCTTGACTCCATGGCAACACTGGGCCTGGCTGCCTATGGCTACGGGATT
CGCTATGAGTTTGGGATTTTTAACCAGAAGATCTCCGGGGGCTGGCAGATGGAGGAGGCC
GATGACTGGCTTCGCTACGGCAACCCCTGGGAGAAGGCCCGGCCCGAGTTCACGCTACCT
GTGCACTTCTACGGCCATGTGGAGCACACCAGCCAGGGTGCCAAGTGGGTGGACACACAG
GTGGTACTGGCCATGCCCTACGATACCCCGGTGCCTGGCTATCGCAACAATGTTGTCAAC
ACCATGCGCCTCTGGTCTGCCAAGGCTCCCAATGACTTCAACCTCAAGGACTTCAATGTC
GGTGGCTACATCCAGGCTGTGTTGGACCGAAACCTGGCGGAGAACATCTCTCGTGTCCTG
TACCCCAATGATAATTTCTTCGAAGGGAAGGAGCTGCGGCTGAAGCAGGAGTATTTCGTG
GTGGCTGCCACCCTCCAGGACATCATCCGTCGCTTCAAGTCTTCCAAGTTCGGCTGCCGT
GATCCCGTGCGCACGAACTTCGATGCCTTCCCAGATAAGGTGGCCATCCAGCTCAATGAC
ACCCACCCCTCCCTGGCCATCCCCGAGCTGATGAGGATCCTGGTGGACCTGGAACGGATG
GACTGGGACAAGGCGTGGGATGTGACAGTGAGGACCTGTGCCTACACCAACCACACGGTG
CTGCCCGAGGCCCTGGAGCGCTGGCCGGTGCACCTCTTGGAGACGCTGCTGCCGCGGCAC
CTCCAGATCATCTACGAGATCAACCAGCGCTTCCTCAACCGGGTGGCGGCCGCATTCCCA
GGGGACGTAGACCGGCTGCGGCGCATGTCGCTGGTGGAGGAGGGCGCAGTGAAGCGCATC
AACATGGCACACCTGTGCATCGCGGGGTCGCACGCCGTCAACGGTGTGGCCCGCATCCAC
TCGGAGATCCTCAAGAAGACCATCTTCAAAGACTTCTATGAGCTGGAGCCTCATAAGTTC
CAGAATAAGACCAACGGCATCACCCCTCGGCGCTGGCTGGTTCTGTGTAACCCCGGGCTG
GCAGAGGTCATTGCTGAGCGCATCGGGGAGGACTTCATCTCTGACCTGGACCAGCTGCGC
AAACTGCTCTCCTTTGTGGATGATGAAGCTTTCATTCGGGATGTGGCCAAAGTGAAGCAG
GAAAACAAGTTGAAGTTTGCTGCCTACCTAGAGAGGGAATACAAAGTCCACATCAACCCC
AACTCACTCTTCGACATCCAGGTGAAGCGGATTCACGAATATAAACGACAGCTCCTCAAC
TGCCTCCATGTCATCACCCTGTACAACCGCATCAAGAGGGAGCCCAATAAGTTTTTTGTG
CCTCGGACTGTGATGATTGGAGGGAAGGCTGCACCTGGGTACCACATGGCCAAGATGATC
ATCAGACTCGTCACAGCCATCGGGGATGTGGTCAACCATGACCCGGCAGTGGGTGACCGC
CTCCGTGTCATCTTCCTGGAGAACTACCGAGTCTCACTGGCCGAGAAAGTGATCCCAGCT
GCAGACCTCTCTGAGCAGATCTCCACTGCGGGCACTGAAGCCTCAGGCACCGGCAACATG
AAGTTCATGCTCAACGGGGCTCTGACCATTGGCACCATGGACGGGGCCAATGTGGAGATG
GCAGAAGAGGCGGGAGAGGAAAACTTCTTCATCTTTGGCATGCGGGTGGAGGATGTGGAT
AAGCTTGACCAAAGAGGGTACAATGCCCAGGAGTACTACGATCGCATTCCTGAGCTTCGG
CAGGTCATTGAGCAGCTGAGCAGTGGCTTCTTCTCCCCCAAACAACCCGACCTGTTCAAG
GACATTGTCAATATGCTCATGCACCATGACCGGTTTAAAGTCTTCGCAGATTATGAAGAC
TACATTAAATGCCAGGAGAAAGTCAGCGCCTGGTACAAGAACCCAAGAGAGTGGACGCGG
ATGGTGATCCGGAACATAGCCACTTCTGGCAAGTTCTCCAGTGACCGCACCATTGCCCAG
TATGCCCGGGAGATCTGGGGTGTGGAGCCTTCCCGCCAGCGCCTGCCAGCCCCGGATGAG
GCCATCTGA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
M32598

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_12_Locus:
11q12-q13.2

# Metabolic_Enzyme_12_SNPs:
rs483962; rs489192; rs686171; rs547066; rs477549; rs565688; rs490980; rs7938455; rs592521; rs589691; rs625172; rs592532; rs506354; rs532747; rs592546; rs474006; rs7126110; rs2959652; rs566653; rs630966; rs637332; rs11821081; rs604595; rs11231866; rs2230309; rs1212604; rs11231865; rs1056780; rs28940587; rs669572; rs12278323; rs9704315; rs34267133; rs3202054; rs576632; rs34991365; rs2071320; rs34447097; rs34154523; rs608261; rs28398896; rs1207113; rs550545; rs555974; rs7114931; rs569200; rs608257; rs7104895; rs34195091; rs35447888; rs34978393; rs2071318; rs11308610; rs12364023; rs2284302; rs34338262; rs35958437; rs35091627; rs35071540; rs1803954; rs1804549; rs2073797; rs2073798; rs2277308; rs2277309; rs2301563; rs2904961; rs2959650; rs3168088; rs3759049; rs3759051; rs3759052; rs3891505; rs484886; rs523200; rs546323; rs547280; rs550930; rs561158; rs588139; rs610637; rs620006; rs637732; rs681791

# Metabolic_Enzyme_12_General_References:
3447177; 3840433; 3466902; 8316268; 8535454; 7603523; 9506549; 10417800; 10382911; 10382912; 10681080; 10590419; 10714589; 10899452; 11706962; 12031624

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5447

# Metabolic_Enzyme_13_Name:
Hexokinase-1

# Metabolic_Enzyme_13_Synonyms:
Hexokinase type I; HK I; Brain form hexokinase

# Metabolic_Enzyme_13_Gene_Name:
HK1

# Metabolic_Enzyme_13_Protein_Sequence:
>Hexokinase1
MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT
VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH
GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV
EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME
ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM
YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG
VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH
PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT
KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV
LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF
TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG
TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD
IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG
IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA
VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG
AALITAVGVRLRTEASS

# Metabolic_Enzyme_13_Number_of_Residues:
917

# Metabolic_Enzyme_13_Molecular_Weight:
102487

# Metabolic_Enzyme_13_Theoretical_pI:
6.78

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Not Available

# Metabolic_Enzyme_13_Specific_Function:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_13_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism;
 map00521  Streptomycin biosynthesis;
 map00530  Aminosugars metabolism

# Metabolic_Enzyme_13_Reaction:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF00349:Hexokinase_1;
PF03727:Hexokinase_2

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
None

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 2.7.1.1

# Metabolic_Enzyme_13_GenBank_ID_Protein:
184021

# Metabolic_Enzyme_13_SwissProt_ID:
HXK1_HUMAN (P19367)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
HK1

# Metabolic_Enzyme_13_Geneatlas_id:
HK1

# Metabolic_Enzyme_13_hgnc_id:
HGNC:4922

# Metabolic_Enzyme_13_PDB_ID:
1HKB

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding

# Metabolic_Enzyme_13_Gene_Sequence:
>2754 bp
ATGATCGCCGCGCAGCTCCTGGCCTATTACTTCACGGAGCTGAAGGATGACCAGGTCAAA
AAGATTGACAAGTATCTGTATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATG
ACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTAATCCAACAGCCACA
GTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGAAAAGGGAGATTTC
ATTGCCCTGGATCTTGGTGGGTCTTCCTTTCGAATTCTGCGGGTGCAAGTGAATCATGAG
AAAAACCAGAATGTTCACATGGAGTCCGAGGTTTATGACACCCCAGAGAACATCGTGCAC
GGCAGTGGAAGCCAGCTTTTTGATCATGTTGCTGAGTGCCTGGGAGATTTCATGGAGAAA
AGGAAGATCAAGGACAAGAAGTTACCTGTGGGATTCACGTTTTCTTTTCCTTGCCAACAA
TCCAAAATAGATGAGGCCATCCTGATCACCTGGACAAAGCGATTTAAAGCGAGCGGAGTG
GAAGGAGCAGATGTGGTCAAACTGCTTAACAAAGCCATCAAAAAGCGAGGGGACTATGAT
GCCAACATCGTAGCTGTGGTGAATGACACAGTGGGCACCATGATGACCTGTGGCTATGAC
GACCAGCACTGTGAAGTCGGCCTGATCATCGGCACTGGCACCAATGCTTGCTACATGGAG
GAACTGAGGCACATTGATCTGGTGGAAGGAGACGAGGGGAGGATGTGTATCAATACAGAA
TGGGGAGCCTTTGGAGACGATGGATCATTAGAAGACATCCGGACAGAGTTTGACAGGGAG
ATAGACCGGGGATCCCTCAACCCTGGAAAACAGCTGTTTGAGAAGATGGTCAGTGGCATG
TACTTGGGAGAGCTGGTTCGACTGATCCTAGTCAAGATGGCCAAGGAGGGCCTCTTATTT
GAAGGGCGGATCACCCCGGAGCTGCTCACCCGAGGGAAGTTTAACACCAGTGATGTGTCA
GCCATCGAAAAGAATAAGGAAGGCCTCCACAATGCCAAAGAAATCCTGACCCGCCTGGGA
GTGGAGCCGTCCGATGATGACTGTGTCTCAGTCCAGCACGTTTGCACCATTGTCTCATTT
CGCTCAGCCAACTTGGTGGCTGCCACACTGGGCGCCATCTTGAACCGCCTGCGTGATAAC
AAGGGCACACCCAGGCTGCGGACCACGGTTGGTGTCGACGGATCTCTTTACAAGACGCAC
CCACAGTATTCCCGGCGTTTCCACAAGACTCTAAGGCGCTTGGTGCCAGACTCCGATGTG
CGCTTCCTCCTCTCGGAGAGTGGCAGCGGCAAGGGGGCTGCCATGGTGACGGCGGTGGCC
TACCGCTTGGCCGAGCAGCACCGGCAGATAGAGGAGACCCTGGCTCATTTCCACCTCACC
AAAGACATGCTGCTGGAGGTGAAGAAGAGGATGCGGGCCGAGATGGAGCTGGGGCTGAGG
AAGCAGACGCACAACAATGCCGTGGTTAAGATGCTGCCCTCCTTCGTCCGGAGAACTCCC
GACGGGACCGAGAATGGTGACTTCTTGGCCCTGGATCTTGGAGGAACCAATTTCCGTGTG
CTGCTGGTGAAAATCCGTAGTGGGAAAAAGAGAACGGTGGAAATGCACAACAAGATCTAC
GCCATTCCTATTGAAATCATGCAGGGCACTGGGGAAGAGCTGTTTGATCACATTGTCTCC
TGCATCTCTGACTTCTTGGACTACATGGGGATCAAAGGCCCCAGGATGCCTCTGGGCTTC
ACGTTCTCATTTCCCTGCCAGCAGACGAGTCTGGACGCGGGAATCTTGATCACGTGGACA
AAGGGTTTTAAGGCAACAGACTGCGTGGGCCACGATGTAGTCACCTTACTAAGGGATGCG
ATAAAAAGGAGAGAGGAATTTGACCTGGACGTGGTGGCTGTGGTCAACGACACAGTGGGC
ACCATGATGACCTGTGCTTATGAGGAGCCCACCTGTGAGGTTGGACTCATTGTTGGGACC
GGCAGCAATGCCTGCTACATGGAGGAGATGAAGAACGTGGAGATGGTGGAGGGGGACCAG
GGGCAGATGTGCATCAACATGGAGTGGGGGGCCTTTGGGGACAACGGGTGTCTGGATGAT
ATCAGGACACACTACGACAGACTGGTGAACGAATATTCCCTAAATGCTGGGAAACAAAGG
TATGAGAAGATGATCAGTGGTATGTACCTGGGTGAAATCGTCCGCAACATCTTAATCGAC
TTCACCAAGAAGGGATTCCTCTTCCGAGGGCAGATCTCTGAGACGATGAAGACCCGGGGC
ATCTTTGAGACCAAGTTTCTCTCTCAGATCGAGAGTGACCGATTAGCACTGCTCCAGGTC
CGGGCTATCCTCCAGCAGCTAGGTCTGAATAGCACCTGCGATGACAGTATCCTCGTCAAG
ACAGTGTGCGGGGTGGTGTCCAGGAGGGCCGCACAGCTGTGTGGCGCAGGCATGGCTGCG
GTTGTGGATAAGATCCGCGAGAACAGAGGACTGGACCGTCTGAATGTGACTGTGGGAGTG
GACGGGACACTCTACAAGCTTCATCCACACTTCTCCAGAATCATGCACCAGACGGTGAAG
GAACTGTCACCAAAATGTAACGTGTCCTTCCTCCTGTCTGAGGATGGCAGCGGCAAGGGG
GCCGCCCTCATCACGGCCGTGGGCGTGCGGTTACGCACAGAGGCAAGCAGCTAA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
M75126

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_13_Locus:
10q22

# Metabolic_Enzyme_13_SNPs:
rs906220; rs1054203; rs748235; rs12254258; rs1133189; rs10998760; rs34616021; rs14006; rs2394539; rs10998704; rs6480394; rs10762281; rs3812689; rs10998703; rs4746834; rs7893994; rs4469773; rs7914134; rs1472817; rs2894081; rs11815833; rs2394540; rs10823332; rs10762280; rs10762277; rs2394543; rs7897621; rs4746837; rs7068435; rs13139; rs1876257; rs5030916; rs10998700; rs11819086; rs12257270; rs2394545; rs11818777; rs10998699; rs10762275; rs7907176; rs7903625; rs12216; rs10998702; rs1472819; rs2394541; rs7095428; rs1472816; rs2394538; rs10823333; rs10998692; rs11813648; rs11818779; rs10762276; rs10823329; rs12242964; rs12242332; rs10762273; rs1472818; rs11818927; rs10998684; rs2394535; rs11815263; rs7095547; rs10823328; rs10823335; rs12751; rs10823331; rs10998694; rs11815943; rs11815513; rs4746833; rs12244771; rs10762278; rs10823334; rs2894080; rs11818799; rs5030886; rs2394537; rs2089356; rs10998696; rs10998689; rs11819674; rs10762279; rs7092374; rs10823330; rs2002905; rs12263326; rs4372334; rs10998691; rs11816714; rs12265826; rs4746836; rs10740318; rs7095424; rs12218331; rs7907242; rs5030949; rs11816128; rs7095579; rs12241382; rs1867972; rs2084274; rs1867971; rs906215; rs1867975; rs749108; rs2305198; rs4537657; rs7084213; rs11596193; rs7909192; rs2305196; rs1227938; rs7072268; rs10823348; rs10159541; rs7094651; rs7084363; rs1900466; rs12414591; rs10762288; rs10733851; rs7921170; rs7921060; rs7095140; rs749107; rs10762282; rs2015803; rs6480396; rs6480404; rs1867973; rs3812691; rs10998738; rs11595647; rs11812791; rs10823360; rs9664217; rs4745988; rs10823350; rs10159477; rs10823357; rs12243794; rs4746848; rs10998730; rs7097078; rs749105; rs7071731; rs4745987; rs16926253; rs7076563; rs3793846; rs10998725; rs2305197; rs4072508; rs7898060; rs11597346; rs6480400; rs11596110; rs7092155; rs2394560; rs4745981; rs4589168; rs11595655; rs10823343; rs3829185; rs11599680; rs10823354; rs6480403; rs12262904; rs10998751; rs4746838; rs10823349; rs11819564; rs10762292; rs1867974; rs906216; rs2278745; rs10998754; rs10823356; rs10159540; rs11818709; rs4746839; rs7079157; rs7088667; rs7094214; rs11599150; rs4746846; rs11598389; rs1900467; rs10823345; rs12265560; rs10762290; rs2394561; rs10823355; rs10823340; rs12244847; rs2305199; rs4746841; rs749106; rs7913579; rs7076745; rs3793845; rs10823341; rs11596587; rs11596868; rs10998720; rs7905437; rs7917338; rs6480402; rs7914033; rs16926244; rs3829183; rs7067927; rs7912524; rs12416320; rs16926252; rs12571072; rs4746849; rs11596199; rs10823339; rs10998728; rs6480398; rs10823342; rs11813750; rs12415409; rs10998739; rs10762284; rs10998742; rs10823353; rs10998741; rs10128334; rs7895704; rs7902303; rs4745982; rs11818471; rs10159490; rs4746847; rs10128330; rs10762285; rs5030915; rs10998719; rs12252483; rs7072349; rs6480399; rs4745986; rs10998752; rs10998710; rs7905515; rs3793847; rs7904932; rs17489768; rs12255367; rs10998747; rs34895304; rs12240847; rs10823358; rs17567544; rs906221; rs12251732; rs10823338; rs10823351; rs9299503; rs10998726; rs10998735; rs12253797; rs10998706; rs7067730; rs12248026; rs12243312; rs12262357; rs4471325; rs11599654; rs12252916; rs3793844; rs7081302; rs10998715; rs12262687; rs16926246; rs7905243; rs10823352; rs10823337; rs10762286; rs10823359; rs10128513; rs10998748; rs17476364; rs10159599; rs11597225; rs10823344; rs10998736; rs7902486; rs12220752; rs7094943; rs7920991; rs10998731; rs16926242; rs10998723; rs12254195; rs10762293; rs4746851; rs7899625; rs16926292; rs10159598; rs2135589; rs10823347; rs4364944; rs7077298; rs10998716; rs16926249; rs11599655; rs12243716; rs7097551; rs10998744; rs10762283; rs12771121; rs7083032; rs12411628; rs10762287; rs10762291; rs7913272; rs12355201; rs5030917; rs10998733; rs10998740; rs1108272; rs4746850; rs11819352; rs10823346; rs12778692; rs6480397; rs11593167; rs11816511; rs11812380; rs10998724; rs2394534; rs1054202; rs34410083; rs35378602; rs41279658; rs12356717; rs35387972; rs12243655; rs35468118; rs1803712; rs10998693; rs35379025; rs5785909; rs35517819; rs35080013; rs34434447; rs10998687; rs28558590; rs12357729; rs12219469; rs12780875; rs34997376; rs35104096; rs12780655; rs10762274; rs34150929; rs12263929; rs10998698; rs10998690; rs10716029; rs2394542; rs12221426; rs4282890; rs12569892; rs7916281; rs35143457; rs2394536; rs36020756; rs3086615; rs7083056; rs10998695; rs1810023; rs2063048; rs36007468; rs10998688; rs11286202; rs35585147; rs28422950; rs35431404; rs12242466; rs35264480; rs35699014; rs14382; rs34382339; rs34539856; rs5785910; rs4745980; rs4638197; rs5785908; rs34031234; rs12262447; rs11815616; rs34736420; rs10672043; rs35376303; rs34164890; rs12253706; rs7914285; rs4622145; rs34547808; rs11556966; rs34453032; rs10998685; rs12241639; rs10998686; rs10998701; rs10998697; rs10400052; rs12268098; rs11819094; rs35607669; rs7905200; rs2394544; rs3750793; rs35895463; rs7083200; rs12220458; rs7914344; rs12259682; rs12571243; rs7894213; rs34610927; rs12253579; rs35804876; rs41279664; rs5030950; rs34938278; rs12242474; rs34931035; rs12780492; rs35306200; rs34327925; rs1057566; rs11819447; rs10668853; rs4453112; rs41279662; rs12252651; rs10998745; rs36104030; rs12247331; rs33984080; rs4366384; rs35347843; rs35619781; rs11592707; rs34834335; rs891564; rs34694521; rs35135619; rs5785912; rs34040090; rs35627580; rs10578071; rs6143971; rs1867970; rs12780794; rs10998734; rs11816980; rs35368978; rs10998714; rs11597178; rs34605664; rs10998756; rs7478446; rs34064357; rs11497990; rs10688656; rs7911813; rs7476246; rs12254694; rs34142395; rs35932296; rs1867976; rs12252489; rs35684348; rs35802626; rs36006142; rs35233497; rs10998757; rs16926233; rs10998709; rs10998722; rs12240898; rs34164799; rs34068824; rs41435648; rs35975244; rs34124986; rs35131910; rs11819725; rs11424399; rs906223; rs7476298; rs35300718; rs10998729; rs36006221; rs5785913; rs11597418; rs34156889; rs11592659; rs10679551; rs10159538; rs10998755; rs35790367; rs36124339; rs5030919; rs16926269; rs41279656; rs12264809; rs35680310; rs11596222; rs34391428; rs36012744; rs34821837; rs10580275; rs10998718; rs12769898; rs7090983; rs34729523; rs35983460; rs11598601; rs34428846; rs11597672; rs35532806; rs10998708; rs35337416; rs2089357; rs3086649; rs10998746; rs10684489; rs5019350; rs12248865; rs35385375; rs35827992; rs11400433; rs10128509; rs35246952; rs35351562; rs33920450; rs10998707; rs35258842; rs10998737; rs16926245; rs34348007; rs12765788; rs12248628; rs7911786; rs10998743; rs17489948; rs34969484; rs6480401; rs12258259; rs34967951; rs11591962; rs41279660; rs35833065; rs10998759; rs3086686; rs12782422; rs10998711; rs35024696; rs34137364; rs33920304; rs35326884; rs34301815; rs35860582; rs906222; rs35929312; rs7093863; rs11389885; rs10998705; rs3812690; rs7081298; rs2894082; rs12360012; rs34309168; rs12769387; rs41279654; rs36096331; rs34767311; rs36022169; rs12247649; rs10542467; rs12770156; rs12259309; rs12245854; rs35510140; rs10998750; rs12357558; rs34815317; rs35215102; rs3956966; rs35733293; rs12765993; rs4745983; rs11295023; rs5019351; rs10998753; rs10998727; rs12769386; rs11421011; rs12243746; rs34133918; rs12356440; rs34966318; rs35451830; rs7094375; rs12359036; rs12763363; rs34977762; rs10047284; rs10998758; rs12098572; rs35694546; rs10603617; rs10531274; rs35035641; rs10998717; rs11593738; rs12257925; rs5030918; rs34367822; rs35534322; rs4745984; rs7072757; rs12243670; rs7088597; rs11267589; rs12411524; rs35376932; rs34620768; rs10823336; rs11597926; rs10998712; rs28510843; rs10536437; rs35922004; rs12263320; rs35828572; rs12246003; rs7094252; rs6480405; rs10998749; rs10159790; rs35341389; rs10998713; rs12264596; rs2278744; rs34085490; rs4746840; rs34767665; rs10998732; rs35490740; rs35026222; rs34941976; rs34818501; rs12264010; rs34125846; rs10998682; rs34564828; rs34015903; rs34747241; rs1000251; rs10740320; rs10998677; rs10998679; rs10998762; rs11813340; rs11815413; rs11817458; rs12244723; rs1227958; rs12776509; rs12781552; rs1549797; rs1549798; rs1549799; rs16926201; rs2278746; rs2611; rs34690134; rs35008643; rs3740601; rs3793849; rs3793850; rs3793851; rs4603200; rs4644560; rs4746832; rs6480393; rs7097827; rs7097971; rs7098065; rs906219; rs986525

# Metabolic_Enzyme_13_General_References:
3207429; 9531504; 1637300; 1985912; 9028305; 10978502; 8706938; 9493266; 9735292; 10574795; 10686099; 7655856

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5611

# Metabolic_Enzyme_14_Name:
Trehalase precursor

# Metabolic_Enzyme_14_Synonyms:
Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase

# Metabolic_Enzyme_14_Gene_Name:
TREH

# Metabolic_Enzyme_14_Protein_Sequence:
>Trehalase precursor
MPGRTWELCLLLLLGLGLGSQEALPPPCESEIYCHGELLNQVQMAKLYQDDKQFVDMPLS
IAPEQVLQTFTELSRDHNHSIPREQLQAFVHEHFQAKGQELQPWTPADWKDSPQFLQKIS
DAKLRAWAGQLHQLWKKLGKKMKPEVLSHPERFSLIYSEHPFIVPGGRFVEFYYWDSYWV
MEGLLLSEMAETVKGMLQNFLDLVKTYGHVPNGGRVYYLQRSQPPLLTLMMDCYLTHTND
TAFLQENIETLALELDFWTKNRTVSVSLEGKNYLLNRYYVPYGGPRPESYSKDVELADTL
PEGDREALWAELKAGAESGWDFSSRWLIGGPNPNSLSGIRTSKLVPVDLNAFLCQAEELM
SNFYSRLGNDSQATKYRILRSQRLAALNTVLWDEQTGAWFDYDLEKKKKNREFYPSNLTP
LWAGCFSDPGVADKALKYLEDNRILTYQYGIPTSLQKTGQQWDFPNAWAPLQDLVIRGLA
KAPLRRAQEVAFQLAQNWIRTNFDVYSQKSAMYEKYDVSNGGQPGGGGEYEVQEGFGWDE
GVVLMLLDRYGDRLTSGAKLAFLEPHCLAATLLPSLLLSLLPW

# Metabolic_Enzyme_14_Number_of_Residues:
583

# Metabolic_Enzyme_14_Molecular_Weight:
66597

# Metabolic_Enzyme_14_Theoretical_pI:
5.19

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  trehalase activity
Function:  alpha,alpha-trehalase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  cellular carbohydrate metabolism
Process:  disaccharide metabolism
Process:  trehalose metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose

# Metabolic_Enzyme_14_Pathway:
map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_14_Reaction:
alpha,alpha-trehalose + H2O = 2 D-glucose

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF01204:Trehalase

# Metabolic_Enzyme_14_Signals:
1-23

# Metabolic_Enzyme_14_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 3.2.1.28

# Metabolic_Enzyme_14_GenBank_ID_Protein:
2789461

# Metabolic_Enzyme_14_SwissProt_ID:
TREA_HUMAN (O43280)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
TREH

# Metabolic_Enzyme_14_Geneatlas_id:
TREH

# Metabolic_Enzyme_14_hgnc_id:
HGNC:12266

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Metabolic_Enzyme_14_Gene_Sequence:
>1752 bp
ATGCCAGGGAGGACCTGGGAGCTGTGCCTGCTACTGCTGCTGGGGCTGGGACTGGGGTCC
CAGGAGGCCCTACCCCCACCCTGTGAGAGTGAGATTTACTGCCACGGGGAGCTCCTAAAC
CAAGTTCAAATGGCCAAGCTCTACCAGGATGACAAGCAGTTTGTGGACATGCCACTGTCT
ATAGCTCCAGAACAAGTCCTGCAGACCTTCACTGAGCTGTCCAGGGACCACAATCACAGC
ATCCCCAGGGAGCAGCTGCAGGCGTTTGTCCACGAACACTTCCAGGCCAAGGGGCAGGAG
CTGCAGCCCTGGACCCCTGCAGACTGGAAAGACAGCCCCCAGTTCCTGCAGAAGATTTCA
GATGCCAAACTGCGTGCCTGGGCAGGGCAGCTGCATCAGCTCTGGAAGAAGCTGGGGAAG
AAGATGAAGCCAGAGGTTCTCAGCCACCCTGAGCGGTTCTCTCTCATATACTCAGAACAT
CCTTTCATTGTGCCTGGCGGTCGCTTTGTTGAGTTCTACTACTGGGACTCCTACTGGGTC
ATGGAGGGTCTGCTCCTCTCAGAGATGGCTGAGACGGTGAAGGGCATGCTGCAGAACTTC
TTGGACCTGGTGAAAACCTATGGGCATGTCCCCAATGGTGGGCGCGTGTACTACTTGCAG
CGGAGCCAGCCCCCACTCTTGACCCTCATGATGGATTGCTACTTGACTCACACCAATGAC
ACCGCCTTTCTACAGGAAAACATTGAAACACTAGCCTTGGAATTGGACTTTTGGACCAAG
AACAGGACTGTCTCTGTGAGCTTGGAGGGAAAGAACTACCTCCTGAATCGCTATTATGTC
CCTTATGGGGGACCCAGGCCTGAGTCCTACAGCAAAGATGTGGAGTTGGCTGACACCTTG
CCAGAAGGAGACCGGGAGGCTCTGTGGGCTGAGCTCAAGGCTGGGGCTGAGTCTGGCTGG
GACTTCTCTTCACGCTGGCTCATTGGAGGCCCAAACCCCAACTCGCTTAGCGGCATCCGA
ACAAGCAAACTGGTGCCTGTTGACCTGAATGCCTTCCTATGCCAAGCAGAGGAGCTGATG
AGCAACTTCTATTCCAGGCTGGGGAACGACTCCCAGGCCACGAAGTACAGAATCCTGCGG
TCGCAGCGCTTGGCCGCCCTGAACACAGTCCTGTGGGATGAGCAGACCGGAGCCTGGTTC
GATTACGACCTTGAGAAGAAGAAGAAAAACCGGGAGTTTTACCCATCCAACCTCACTCCA
CTCTGGGCCGGGTGTTTCTCTGACCCTGGCGTGGCGGACAAGGCTCTGAAATACCTGGAG
GACAACCGGATCCTGACTTACCAGTATGGGATCCCGACCTCTCTCCAGAAGACAGGCCAG
CAGTGGGATTTCCCCAATGCCTGGGCCCCCCTGCAGGACTTGGTCATCAGAGGCCTGGCC
AAGGCACCTTTACGTCGGGCCCAGGAAGTGGCTTTCCAGCTGGCTCAGAATTGGATCCGA
ACCAATTTTGATGTCTACTCGCAGAAGTCAGCCATGTATGAGAAGTATGACGTCAGCAAC
GGTGGACAGCCCGGTGGGGGAGGAGAATATGAAGTTCAGGAGGGATTTGGCTGGGACGAA
GGTGTGGTCCTGATGCTGCTGGACCGCTATGGTGACCGGCTGACCTCAGGGGCCAAGCTG
GCTTTCCTGGAGCCCCACTGCCTGGCGGCCACCCTTCTGCCCAGCCTCCTGCTCAGCCTC
CTGCCATGGTGA

# Metabolic_Enzyme_14_GenBank_ID_Gene:
AB000824

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_14_Locus:
11q23.3

# Metabolic_Enzyme_14_SNPs:
rs561845; rs7926959; rs519848; rs642530; rs642497; rs4936433; rs625513; rs693306; rs638301; rs514143; rs4938529; rs10892252; rs563549; rs638805; rs673770; rs2277296; rs558907; rs6589673; rs7926970; rs592280; rs7106652; rs508579; rs509641; rs510408; rs486462; rs4474473; rs12796373; rs4938530; rs4331144; rs7106421; rs11602869; rs546890; rs692848; rs7106851; rs613377; rs7926944; rs7122254; rs571751; rs11216942; rs654792; rs7940326; rs11216943; rs4938525; rs610664; rs7106022; rs12798453; rs2508573; rs549370; rs7944564; rs11605069; rs555356; rs10790256; rs607527; rs2276065; rs543413; rs600969; rs1784298; rs692750; rs745663; rs2276064; rs647878; rs10892251; rs11605801; rs11827611; rs507080; rs656505; rs12225548; rs4589335; rs7120027; rs1783935; rs12294955; rs562313; rs659969; rs656575; rs526597; rs570695; rs2508991; rs12577485; rs660489; rs4938522; rs537369; rs4457789; rs2276063; rs7935904; rs504206; rs4938523; rs7932296; rs543327; rs520543; rs671133; rs7950613; rs582630; rs1783936; rs669811; rs667982; rs527475; rs558593; rs10790258; rs1784296; rs10790257; rs585039; rs34626072; rs561569; rs2508994; rs1784542; rs36125121; rs540444; rs1784854; rs12361366; rs4938524; rs693037; rs7936203; rs12799314; rs3016617; rs35567298; rs34250292; rs1784541; rs34384440; rs12272018; rs34680761; rs10892253; rs34167675; rs36083539; rs693465; rs34782041; rs35357070; rs36077162; rs634779; rs498517; rs2509315; rs35948375; rs2509314; rs634731; rs35689449; rs12788655; rs12800792; rs693945; rs533144; rs1614560; rs3016616; rs2277297; rs497590; rs34771173; rs34440046; rs516072; rs36093233; rs7940482; rs12293958; rs3016522; rs35728464; rs12788848; rs3016615; rs12270895; rs3016614; rs3016466; rs34007046; rs625918; rs11216944; rs34643799; rs525485; rs556685; rs7481249; rs12293350; rs10719392; rs12417030; rs629574; rs36068734; rs34681527; rs33918305; rs687190; rs11381735; rs506234; rs567518; rs583092; rs548915; rs12280064; rs34413584; rs11602114; rs34124019; rs10719391; rs35085066; rs12801676; rs619099; rs35991020; rs494610; rs504495; rs7481271; rs556699; rs555849; rs11307172; rs34485469; rs35740157; rs28452542; rs11381679; rs35368922; rs34661262; rs545940; rs35892163; rs499156; rs684019; rs484246; rs10719394; rs35088386; rs7928106; rs579827; rs11464189; rs684017; rs35263635; rs11318522; rs34808635; rs7481250; rs570494; rs7483149; rs35776573; rs10719393; rs1784544; rs1133780; rs34978247; rs1186069; rs7928805; rs11464188; rs1784851; rs6144529; rs527619; rs11455968; rs527561; rs1784852; rs35874028; rs1784849; rs1784853; rs35874954; rs1063496; rs11216951; rs11605922; rs1171806; rs12281836; rs17748; rs4393358; rs4486664; rs471227; rs478371; rs481903; rs488141; rs493834; rs494560; rs497678; rs502601; rs506781; rs506839; rs516153; rs519982; rs523793; rs533646; rs540800; rs541212; rs544007; rs544452; rs575814; rs601318; rs614590; rs644498; rs644867; rs653008; rs658676; rs6589668; rs668628; rs7108144; rs7389; rs7479362

# Metabolic_Enzyme_14_General_References:
9427547; 8773341

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5612

# Metabolic_Enzyme_15_Name:
Glycogen phosphorylase, brain form

# Metabolic_Enzyme_15_Synonyms:
Not Available

# Metabolic_Enzyme_15_Gene_Name:
PYGB

# Metabolic_Enzyme_15_Protein_Sequence:
>Glycogen phosphorylase, brain form
MAKPLTDSEKRKQISVRGLAGLGDVAEVRKSFNRHLHFTLVKDRNVATPRDYFFALAHTV
RDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTMVNLGLQNACDEAIYQLGLDL
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKIVNGWQVEEA
DDWLRYGNPWEKARPEYMLPVHFYGRVEHTPDGVKWLDTQVVLAMPYDTPVPGYKNNTVN
TMRLWSAKAPNDFKLQDFNVGDYIEAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTCFETFPDKVAIQLNDTHPALSIPELMRILVDVEKV
DWDKAWEITKKTCAYTNHTVLPEALERWPVSMFEKLLPRHLEIIYAINQRHLDHVAALFP
GDVDRLRRMSVIEEGDCKRINMAHLCVIGSHAVNGVARIHSEIVKQSVFKDFYELEPEKF
QNKTNGITPRRWLLLCNPGLADTIVEKIGEEFLTDLSQLKKLLPLVSDEVFIRDVAKVKQ
ENKLKFSAFLEKEYKVKINPSSMFDVHVKRIHEYKRQLLNCLHVVTLYNRIKRDPAKAFV
PRTVMIGGKAAPGYHMAKLIIKLVTSIGDVVNHDPVVGDRLKVIFLENYRVSLAEKVIPA
ADLSQQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGAENLFIFGLRVEDVE
ALDRKGYNAREYYDHLPELKQAVDQISSGFFSPKEPDCFKDIVNMLMHHDRFKVFADYEA
YMQCQAQVDQLYRNPKEWTKKVIRNIACSGKFSSDRTITEYAREIWGVEPSDLQIPPPNI
PRD

# Metabolic_Enzyme_15_Number_of_Residues:
843

# Metabolic_Enzyme_15_Molecular_Weight:
96697

# Metabolic_Enzyme_15_Theoretical_pI:
6.85

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
Function:  phosphorylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_15_Specific_Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

# Metabolic_Enzyme_15_Pathway:
map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_15_Reaction:
(1,4-alpha-D-glucosyl)n + phosphate = (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00343:Phosphorylase

# Metabolic_Enzyme_15_Signals:
None

# Metabolic_Enzyme_15_Transmembrane_Regions:
None

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 2.4.1.1

# Metabolic_Enzyme_15_GenBank_ID_Protein:
307200

# Metabolic_Enzyme_15_SwissProt_ID:
PYGB_HUMAN (P11216)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
PYGB

# Metabolic_Enzyme_15_Geneatlas_id:
PYGB

# Metabolic_Enzyme_15_hgnc_id:
HGNC:9723

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Not Available

# Metabolic_Enzyme_15_Gene_Sequence:
>2592 bp
ATGGGCGAACCGCTGACGGACAGCGAGAAGCGGAAGCAGATCAGCGTGCGCGGCCTGGCG
GGGCTAGGCGACGTGGCCGAGGTGCGGAAGAGCTTCAACCGGCACTTGCACTTCACGCTG
GTCAAGGACCGCAATGTGGCCACGCCCCGCGACTACTTCTTCGCGCTGGCGCACACGGTG
CGCGACCACCTCGTGGGCCGCTGGATCCGCACGCAGCAGCACTACTACGAGCGCGACCCC
AAGCGAATTTATTATCTTTCCCTGGAATTCTACATGGGTCGCACGCTGCAGAACACGATG
GTGAACCTGGGCCTTCAGAATGCCTGCGATGAAGCCATCTATCAGTTGGGGTTAGACTTG
GAGGAACTCGAGGAGATAGAAGAAGATGCTGGCCTTGGGAATGGAGGCCTGGGGAGGCTG
GCAGCGTGTTTCCTTGACTCAATGGCTACCTTGGGCCTGGCAGCATACGGCTATGGAATC
CGCTATGAATTTGGGATTTTTAACCAGAAGATTGTCAATGGCTGGCAGGTAGAGGAGGCC
GATGACTGGCTGCGCTACGGCAACCCCTGGGAGAAAGCGCGGCCTGAGTATATGCTTCCC
GTGCACTTCTACGGACGCGTGGAGCACACCCCCGACGGCGTGAAGTGGCTGGACACACAG
GTGGTGCTGGCCATGCCCTACGACACCCCAGTGCCCGGCTACAAGAACAACACCGTCAAC
ACCATGCGGCTGTGGTCCGCAAGGGCTCCCAACGACTTCAAGCTGCAGGACTTCAACGTG
GGAGACTACATCGAGGCGGTCCTGGACCGGAACTTGGCTGAGAACATCTCCAGGGTCCTG
TATCCAAATGATAACTTCTTTGAGGGGAAGGAGCTGCGGCTGAAGCAGGAGTACTTCGTG
GTGGGCGCCACGCTCCAGGACATCATCCGCCGCTTCAAGTCGTCCAAGTTCGGCTGCCGG
GACCCTGTGAGAACCTGTTTCGAGACGTTCCCAGACAAGGTGGCCATCCAGCTGAACGAC
ACCCACCCCGCCCTCTCCATCCCTGAGCTCATGCGGATCCTGGTGGACGTGGAGAAGGTG
GACTGGGACAAGGCCTGGGAAATCACGAAGAAGACCTGTGCATACACCAACCACACTGTG
CTGCCTGAGGCCTTGGAGCGCTGGCCCGTGTCCATGTTTGAGAAGCTGCTGCCGCGGCAC
CTGGAGATAATCTATGCCATCAACCAGCGGCACCTGGACCACGTGGCCGCGCTGTTTCCC
GGCGATGTGGACCGCCTGCGCAGGATGTCTGTGATCGAGGAGGGGGACTGCAAGCGGATC
AACATGGCCCACCTGTGTGTGATTGGGTCCCATGCTGTCAATGGTGTGGCGAGGATCCAC
TCGGAGATCGTGAAACAGTCGGTCTTTAAGGATTTTTATGAACTGGAGCCAGAGAAGTTC
CAGAATAAGACCAATGGCATCACCCCCCGCCGGTGGCTGCTGCTGTGCAACCCGGGGCTG
GCCGATACCATCGTGGAGAAAATTGGGGAGGAGTTCCTGACTGACCTGAGCCAGCTGAAG
AAGCTGCTGCCGCTGGTCAGTGACGAGGTGTTCATCAGGGACGTGGCCAAGGTCAAACAG
GAGAACAAGCTCAAGTTCTCGGCCTTCCTGGAGAAGGAGTACAAGGTGAAGATCAACCCC
TCCTCCATGTTCGATGTGCATGTGAAGAGGATCCACGAGTACAAGCGGCAGCTGCTCAAC
TGCCTGCACGTCGTCACCCTGTACAATCGAATCAAGAGAGACCCGGCCAAGGCTTTTGTG
CCCAGGACTGTTATGATTGGGGGCAAGGCAGCGCCCGGTTACCACATGGCCAAGCTGATC
ATCAAGTTGGTCACCTCCATCGGCGACGTCGTCAATCATGACCCAGTTGTGGGTGACAGG
TTGAAAGTGATCTTCCTGGAGAACTACCGTGTGTCCTTGGCTGAGAAAGTGATCCCGGCC
GCTGATCTGTCGCAGCAGATCTCCACTGCAGGCACCGAGGCCTCAGGCACAGGCAACATG
AAGTTCATGCTCAACGGGGCCCTCACCATCGGCACCATGGACGGCGCCAACGTGGAGATG
GCCGAGGAGGCCGGGGCCGAGAACCTCTTCATCTTCGGCCTGCGGGTGGAGGATGTCGAG
GCCTTGGACCGGAAAGGGTACAATGCCAGGGAGTACTACGACCACCTGCCCGAGCTGAAG
CAGGCCGTGGACCAGATCAGCAGTGGCTTTTTTTCTCCCAAGGAGCCAGACTGCTTCAAG
GACATCGTGAACATGCTGATGCACCATGACAGGTTCAAGGTGTTTGCAGACTATGAAGCC
TACATGCAGTGCCAGGCACAGGTGGACCAGCTGTACCGGAACCCCAAGGAGTGGACCAAG
AAGGTCATCAGGAACATCGCCTGCTCGGGCAAGTTCTCCAGTGACCGGACCATCACGGAG
TATGCACGGGAGATCTGGGGTGTGGAGCCCTCCGACCTGCAGCTTCAGCACCTGCCCCAC
CCAGAGTGGGAGTCAGGTGGAGCCACCTGCTGGGCTCCCCCAGAACTTTGCACACATCTT
GCTATGTATTAG

# Metabolic_Enzyme_15_GenBank_ID_Gene:
J03544

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_15_Locus:
20p11.2-p11.1

# Metabolic_Enzyme_15_SNPs:
rs2227891; rs2228976; rs2227892; rs2227890; rs2228977; rs16987612; rs6515626; rs6050486; rs2261720; rs2257808; rs2261109; rs910996; rs2424698; rs6050510; rs2261785; rs2424699; rs2257233; rs2261794; rs2257705; rs2261115; rs2261698; rs2257809; rs2281562; rs2257464; rs2261784; rs2260997; rs2474772; rs2257461; rs2424700; rs2261795; rs7269045; rs6050512; rs2261790; rs2261753; rs2261747; rs2257712; rs2474769; rs2257370; rs6050511; rs6037075; rs1555329; rs2258052; rs6115107; rs2281558; rs3787078; rs2258053; rs2145125; rs2258201; rs6107024; rs11697384; rs6115109; rs2257991; rs8118763; rs753009; rs910997; rs1555331; rs6107023; rs6115118; rs2258563; rs6050509; rs6050502; rs6037070; rs4813555; rs7273544; rs6115115; rs2257432; rs6115101; rs2281559; rs8184820; rs2474767; rs3787082; rs2424704; rs8116542; rs6050487; rs2424701; rs3787081; rs6138555; rs3787080; rs1555330; rs8124539; rs8114792; rs2500411; rs2258135; rs2474777; rs6115117; rs2257982; rs8120601; rs6115114; rs6107017; rs2474763; rs12624460; rs2257988; rs11087508; rs2474770; rs6037071; rs13038092; rs2500410; rs6050513; rs11087511; rs6132824; rs2474773; rs2424703; rs6050501; rs2387734; rs11699953; rs6076328; rs6050488; rs12624693; rs2145126; rs12625357; rs12625045; rs2474766; rs11697736; rs6107021; rs6132825; rs6115121; rs2500413; rs7274919; rs6037069; rs6115106; rs3002702; rs2474762; rs2257649; rs8115188; rs2180597; rs6115116; rs6050515; rs4815398; rs2257985; rs12624472; rs8125980; rs6107022; rs6107019; rs2258066; rs2258617; rs2273473; rs6138553; rs7274104; rs6132822; rs11549036; rs6037077; rs6115125; rs6115124; rs35481467; rs6050484; rs35073849; rs2228978; rs6115120; rs35669741; rs35189278; rs6083789; rs2474764; rs11474310; rs34233544; rs4619688; rs34170256; rs11483996; rs34871259; rs12625447; rs7272247; rs11472555; rs6083794; rs6115113; rs6115108; rs8125437; rs6050485; rs11472504; rs11471241; rs35760653; rs2254046; rs3838000; rs6050503; rs7274130; rs11473890; rs6050520; rs6083790; rs6050507; rs2180596; rs6115102; rs10582106; rs6115129; rs6037079; rs7353137; rs11466827; rs6050493; rs2474774; rs6050491; rs6107018; rs35358504; rs11468635; rs11468776; rs13043218; rs34067778; rs34827380; rs11475816; rs41282330; rs6138556; rs5841050; rs34496209; rs6050498; rs13043643; rs34360139; rs35375864; rs13044624; rs6107020; rs6138551; rs11699652; rs2474776; rs6115123; rs2474768; rs6050508; rs11312793; rs35716293; rs6115104; rs35058859; rs36105797; rs6050494; rs13433150; rs11470476; rs34346429; rs6050492; rs11471520; rs6115128; rs6115103; rs12106151; rs2983489; rs6050504; rs11468520; rs6083788; rs41282328; rs6050490; rs11087510; rs28770021; rs35286896; rs4364079; rs6050521; rs11475085; rs6138558; rs6037068; rs7352961; rs11480235; rs33973694; rs7269584; rs6115130; rs2983490; rs11350552; rs6115110; rs5841051; rs35988788; rs35243193; rs2281561; rs6050495; rs6138552; rs6076330; rs35609563; rs12626048; rs7363911; rs6083793; rs6115122; rs34299454; rs6115105; rs34646441; rs2474775; rs35264724; rs33964550; rs6050505; rs12625048; rs2474771; rs11477346; rs2500426; rs6050522; rs6050519; rs34336965; rs6138559; rs8114789; rs36117882; rs11470854; rs35760227; rs3841696; rs5841052; rs13433144; rs2281560; rs6050523; rs1118963; rs33999482; rs35370770; rs34672197; rs13038488; rs35258354; rs34316192; rs34427422; rs35256912; rs11479739; rs6037073; rs13043662; rs3787079; rs34204571; rs6083791; rs6115111; rs11908154; rs34776023; rs7272959; rs1077889; rs28881233; rs6083792; rs11480711; rs6138554; rs13037005; rs2474765; rs35263526; rs6050483; rs34955390; rs1046073; rs10966; rs1130694; rs11905042; rs2258719; rs2258769; rs2259873; rs2260197; rs2261796; rs2474779; rs2474780; rs6050471; rs6050473; rs6050475; rs6050476; rs6050477; rs6050481; rs6107016; rs6107027; rs6115098; rs6115100; rs7019; rs7344105; rs746748; rs8119343; rs9927

# Metabolic_Enzyme_15_General_References:
3346228; 2615594; 11780052; 12665801

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5613

# Metabolic_Enzyme_16_Name:
Glucose-6-phosphatase

# Metabolic_Enzyme_16_Synonyms:
G6Pase; G-6-Pase

# Metabolic_Enzyme_16_Gene_Name:
G6PC

# Metabolic_Enzyme_16_Protein_Sequence:
>Glucose6phosphatase
MEEGMNVLHDFGIQSTHYLQVNYQDSQDWFILVSVIADLRNAFYVLFPIWFHLQEAVGIK
LLWVAVIGDWLNLVFKWILFGQRPYWWVLDTDYYSNTSVPLIKQFPVTCETGPGSPSGHA
MGTAGVYYVMVTSTLSIFQGKIKPTYRFRCLNVILWLGFWAVQLNVCLSRIYLAAHFPHQ
VVAGVLSGIAVTETFSHIHSIYNASLKKYFLITFFLFSFAIGFYLLLKGLGVDLLWTLEK
AQRWCEQPEWVHIDTTPFASLLKNLGTLFGLGLALNSSMYRESCKGKLSKWLPFRLSSIV
ASLVLLHVFDSLKPPSQVELVFYVLSFCKSAVVPLASVSVIPYCLAQVLGQPHKKSL

# Metabolic_Enzyme_16_Number_of_Residues:
357

# Metabolic_Enzyme_16_Molecular_Weight:
40514

# Metabolic_Enzyme_16_Theoretical_pI:
8.61

# Metabolic_Enzyme_16_GO_Classification:
Not Available

# Metabolic_Enzyme_16_General_Function:
Not Available

# Metabolic_Enzyme_16_Specific_Function:
May be a single membrane channel protein acting both as a hydrolase and a translocase. It is the key enzyme in homeostatic regulation of blood glucose levels

# Metabolic_Enzyme_16_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_16_Reaction:
D-glucose 6-phosphate + H2O = D-glucose + phosphate

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF01569:PAP2

# Metabolic_Enzyme_16_Signals:
None

# Metabolic_Enzyme_16_Transmembrane_Regions:
30-46
59-75
153-169
211-227
296-312
320-336

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 3.1.3.9

# Metabolic_Enzyme_16_GenBank_ID_Protein:
452444

# Metabolic_Enzyme_16_SwissProt_ID:
G6PT_HUMAN (P35575)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
G6PC

# Metabolic_Enzyme_16_Geneatlas_id:
G6PC

# Metabolic_Enzyme_16_hgnc_id:
HGNC:4056

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein

# Metabolic_Enzyme_16_Gene_Sequence:
>1074 bp
ATGGAGGAAGGAATGAATGTTCTCCATGACTTTGGGATCCAGTCAACACATTACCTCCAG
GTGAATTACCAAGACTCCCAGGACTGGTTCATCTTGGTGTCCGTGATCGCAGACCTCAGG
AATGCCTTCTACGTCCTCTTCCCCATCTGGTTCCATCTTCAGGAAGCTGTGGGCATTAAA
CTCCTTTGGGTAGCTGTGATTGGAGACTGGCTCAACCTCGTCTTTAAGTGGATTCTCTTT
GGACAGCGTCCATACTGGTGGGTTTTGGATACTGACTACTACAGCAACACTTCCGTGCCC
CTGATAAAGCAGTTCCCTGTAACCTGTGAGACTGGACCAGGGAGCCCCTCTGGCCATGCC
ATGGGCACAGCAGGTGTATACTACGTGATGGTCACATCTACTCTTTCCATCTTTCAGGGA
AAGATAAAGCCGACCTACAGATTTCGGTGCTTGAATGTCATTTTGTGGTTGGGATTCTGG
GCTGTGCAGCTGAATGTCTGTCTGTCACGAATCTACCTTGCTGCTCATTTTCCTCATCAA
GTTGTTGCTGGAGTCCTGTCAGGCATTGCTGTTACAGAAACTTTCAGCCACATCCACAGC
ATCTATAATGCCAGCCTCAAGAAATATTTTCTCATTACCTTCTTCCTGTTCAGCTTCGCC
ATCGGATTTTATCTGCTGCTCAAGGGACTGGGTGTAGACCTCCTGTGGACTCTGGAGAAA
GCCCAGAGGTGGTGCGAGCAGCCAGAATGGGTCCACATTGACACCACACCCTTTGCCAGC
CTCCTCAAGAACCTGGGCACGCTCTTTGGCCTGGGGCTGGCTCTCAACTCCAGCATGTAC
AGGGAGAGCTGCAAGGGGAAACTCAGCAAGTGGCTCCCATTCCGCCTCAGCTCTATTGTA
GCCTCCCTCGTCCTCCTGCACGTCTTTGACTCCTTGAAACCCCCATCCCAAGTCGAGCTG
GTCTTCTACGTCTTGTCCTTCTGCAAGAGTGCGGTAGTGCCCCTGGCATCCGTCAGTGTC
ATCCCCTACTGCCTCGCCCAGGTCCTGGGCCAGCCGCACAAGAAGTCGTTGTAA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
U01120

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_16_Locus:
17q21

# Metabolic_Enzyme_16_SNPs:
rs161628; rs2229611; rs161620; rs161626; rs2593595; rs161621; rs161630; rs161634; rs161633; rs161631; rs161622; rs692466; rs161625; rs161632; rs555314; rs7213700; rs9899535; rs161627; rs9902963; rs692180; rs1801176; rs1801175; rs9905900; rs7210335; rs34960677; rs34959065; rs36092308; rs11436510; rs34537381; rs447268; rs692076; rs571000; rs2667937; rs7225801; rs35482744; rs12936784; rs35983714; rs2667938; rs34791838; rs673895; rs161629; rs161623; rs161624; rs28583935; rs570217; rs12450501; rs36031531; rs12103792; rs525189; rs36047740; rs11652764; rs2667935; rs4793182; rs35905772; rs11649970; rs1185293; rs12603239; rs172830; rs2593596; rs323495; rs324079; rs324080; rs324082; rs571330; rs691547; rs692198; rs7209982; rs7215072; rs8079497

# Metabolic_Enzyme_16_General_References:
8211187; 9705299; 7573034; 7623438; 7655466; 9001800; 8733042; 10094563; 10447271; 10612834

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5614

# Metabolic_Enzyme_17_Name:
Beta-1,4-galactosyltransferase 1

# Metabolic_Enzyme_17_Synonyms:
Beta-1,4-GalTase 1; Beta4Gal-T1; b4Gal-T1; UDP-galactose:beta-N-acetylglucosamine beta- 1,4-galactosyltransferase 1; UDP-Gal:beta-GlcNAc beta-1,4- galactosyltransferase 1[Includes: Lactose synthase A protein; Nal synthetase; Beta-N-acetylglucosaminylglycopeptide beta-1,4- galactosyltransferase

# Metabolic_Enzyme_17_Gene_Name:
B4GALT1

# Metabolic_Enzyme_17_Protein_Sequence:
>Beta1,4galactosyltransferase 1
MRLREPLLSGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLSRLPQLVGVSTPL
QGGSNSAAAIGQSSGELRTGGARPPPPLGASSQPRPGGDSSPVVDSGPGPASNLTSVPVP
HTTALSLPACPEESPLLVGPMLIEFNMPVDLELVAKQNPNVKMGGRYAPRDCVSPHKVAI
IIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQAGDTIFNRAKLLNVGFQEALKDYD
YTCFVFSDVDLIPMNDHNAYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLTI
NGFPNNYWGWGGEDDDIFNRLVFRGMSISRPNAVVGRCRMIRHSRDKKNEPNPQRFDRIA
HTKETMLSDGLNSLTYQVLDVQRYPLYTQITVDIGTPS

# Metabolic_Enzyme_17_Number_of_Residues:
398

# Metabolic_Enzyme_17_Molecular_Weight:
43921

# Metabolic_Enzyme_17_Theoretical_pI:
8.77

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Not Available

# Metabolic_Enzyme_17_Specific_Function:
The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix

# Metabolic_Enzyme_17_Pathway:
map00510  N-Glycan biosynthesis;
 map00533  Keratan sulfate biosynthesis

# Metabolic_Enzyme_17_Reaction:
UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF02709:Galactosyl_T_2

# Metabolic_Enzyme_17_Signals:
1-37

# Metabolic_Enzyme_17_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 2.4.1.22;EC 2.4.1.90;E

# Metabolic_Enzyme_17_GenBank_ID_Protein:
29424

# Metabolic_Enzyme_17_SwissProt_ID:
B4GT1_HUMAN (P15291)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
B4GALT1

# Metabolic_Enzyme_17_Geneatlas_id:
B4GALT1

# Metabolic_Enzyme_17_hgnc_id:
HGNC:924

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Isoform Long:Golgi apparatus; Golgi stack; Golgi stack membrane; single-pass type II membrane protein. Cell membrane; single-pass type II membrane protein. Cell surface. Isoform Short:Golgi apparatus; Golgi stack; Golgi stack membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Isoforms Long and Short are found in trans cisternae of Golgi. A soluble form, found in body fluids, is produced by proteolytic processing, is present in body fluids

# Metabolic_Enzyme_17_Gene_Sequence:
>1203 bp
ATGAGGCTTCGGGAGCCGCTCCTGAGCGGCGCCGCGATGCCAGGCGCGTCCCTACAGCGG
GCCTGCCGCCTGCTCGTGGCCGTCTGCGCTCTGCACCTTGGCGTCACCCTCGTTTACTAC
CTGGCTGGCCGCGACCTGAGCCGCCTGCCCCAACTGGTCGGAGTCTCCACACCGCTGCAG
GGCGGCTCGAACAGTGCCGCCGCCATCGGGCAGTCCTCCGGGGAGCTCCGGACCGGAGGG
GCCCGGCCGCCGCCTCCTCTAGGCGCCTCCTCCCAGCCGCGCCCGGGTGGCGACTCCAGC
CCAGTCGTGGATTCTGGCCCTGGCCCCGCTAGCAACTTGACCTCGGTCCCAGTGCCCCAC
ACCACCGCACTGTCGCTGCCCGCCTGCCCTGAGGAGTCCCCGCTGCTTGTGGGCCCCATG
CTGATTGAGTTTAACATGCCTGTGGACCTGGAGCTCGTGGCAAAGCAGAACCCAAATGTG
AAGATGGGCGGCCGCTATGCCCCCAGGGACTGCGTCTCTCCTCACAAAGTGGCCATCATC
ATTCCATTCCGCAACCGGCAGGAGCACCTCAAGTACTGGCTATATTATTTGCACCCAGTC
CTGCAGCGCCAGCAGCTGGACTATGGCATCTATGGCATCTATGTTATCAACCAGGCGGGA
GACACTATATTCAATCGTGCTAAGCTCCTCAATGTTGGCTTTCAAGAAGCCTTGAAGGAC
TATGACTACACCTGCTTTGTGTTTAGTGACGTGGACCTCATCCCAATGAATGACCATAAT
GCGTACAGGTGTTTTTCACAGCCACGGCACATTTCCGTTGCAATGGATAAGTTTGGATTC
AGCCTACCTTATGTTCAGTATTTTGGAGGTGTCTCTGCTCTAAGTAAACAACAGTTTCTA
ACCATCAATGGATTTCCTAATAATTATTGGGGCTGGGGAGGAGAAGATGATGACATTTTT
AACAGATTAGTTTTTAGAGGCATGTCTATATCTCGCCCAAATGCTGTGGTCGGGAGGTGT
CGCATGATCCGCCACTCAAGAGACAAAAAAAATGAACCCAATCCTCAGAGGTTTGACCGA
ATTGCACACACAAAGGAGACAATGCTCTCTGATGGTTTGAACTCACTCACCTACCAGGTG
CTGGATGTACAGAGATACCCATTGTATACCCAAATCACAGTGGACATCGGGACACCGAGC
TAG

# Metabolic_Enzyme_17_GenBank_ID_Gene:
X14085

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_17_Locus:
9p13

# Metabolic_Enzyme_17_SNPs:
rs1065764; rs1065765; rs7019896; rs7019909; rs869; rs10971412; rs17326497; rs10412; rs16918998; rs17247945; rs17326539; rs16918999; rs13289751; rs1018; rs7041783; rs1803716; rs16918997; rs1411609; rs7849148; rs913214; rs10758189; rs3780490; rs10738906; rs10971419; rs3780487; rs7864705; rs10971424; rs2031902; rs7865745; rs10813957; rs7036812; rs10124479; rs10113903; rs3780480; rs10217267; rs10738907; rs2770807; rs10971418; rs1328898; rs4879666; rs4584234; rs2209948; rs10813950; rs3780499; rs3780481; rs1969977; rs3818593; rs10117038; rs7029897; rs1328899; rs7873903; rs3824458; rs10758194; rs1969976; rs3780484; rs12379501; rs3780495; rs3824459; rs10116966; rs4879665; rs3780488; rs10758192; rs10121987; rs7868781; rs2183124; rs6476400; rs10813954; rs3780485; rs6476399; rs3780489; rs3780491; rs10738905; rs10813958; rs7850878; rs7850730; rs959749; rs10758188; rs10738909; rs12683460; rs11792560; rs10813956; rs7873077; rs7868653; rs2376766; rs7859454; rs10758191; rs10813955; rs7043474; rs10813959; rs6476402; rs17327324; rs7020500; rs2774272; rs12346594; rs1571436; rs4878525; rs10511909; rs7045547; rs7028949; rs3780494; rs10758190; rs6476398; rs10971414; rs17327015; rs2567408; rs10813952; rs10813951; rs10971426; rs7868663; rs7467148; rs12343079; rs10813953; rs10971425; rs3780486; rs10971430; rs11793020; rs13283483; rs10114471; rs10971417; rs12554995; rs958532; rs3780483; rs1060534; rs2770808; rs7851385; rs7873182; rs10971415; rs10813948; rs12342831; rs7868990; rs10971422; rs10813949; rs6476401; rs7865362; rs10217770; rs12554628; rs605915; rs7037398; rs3758273; rs9169; rs1064905; rs1142254; rs1064906; rs1064910; rs1064909; rs35952183; rs10607134; rs3841451; rs1803717; rs11548671; rs1064950; rs41274019; rs41316025; rs7041909; rs41274017; rs41274023; rs41303661; rs35504729; rs41274021; rs34791389; rs13764; rs35436284; rs34856798; rs10453199; rs10971420; rs7874095; rs3837268; rs35478918; rs3780493; rs13298273; rs34636838; rs35457360; rs7863963; rs11291171; rs13299659; rs34367010; rs34420698; rs10971429; rs35406954; rs34302260; rs10971433; rs11290421; rs35401344; rs2567412; rs36007663; rs35937194; rs11793894; rs12378256; rs660497; rs28429368; rs3837267; rs1072601; rs3780478; rs12376786; rs13296530; rs33951459; rs12552871; rs11449568; rs1360056; rs2481060; rs35102741; rs10813947; rs12685679; rs7850651; rs11793877; rs11369539; rs36047322; rs34402268; rs12350201; rs10453200; rs35177345; rs2889461; rs35233105; rs10701535; rs28389469; rs34066440; rs13301084; rs10570814; rs35065587; rs12375544; rs2067749; rs1753855; rs34433922; rs11414746; rs12352863; rs35653104; rs10971427; rs1887876; rs13296176; rs35113991; rs34931533; rs3780479; rs2435973; rs13298728; rs35354911; rs13289149; rs4878526; rs10758193; rs913215; rs34813509; rs34018955; rs5897535; rs34554920; rs10971421; rs34653816; rs1410774; rs35909904; rs34914931; rs3065241; rs34804483; rs35058735; rs10116935; rs36205834; rs10574717; rs35559504; rs36085848; rs34243341; rs6150980; rs10971431; rs11795362; rs865515; rs34566644; rs13297246; rs13284257; rs35876633; rs1137643; rs35799631; rs34553800; rs34778677; rs3065244; rs1137642; rs35494749; rs3780492; rs34047756; rs10121006; rs864925; rs36044755; rs35729023; rs10633991; rs34888597; rs35507104; rs5897536; rs34919692; rs35884423; rs13290301; rs10971428; rs13287923; rs10971416; rs13287775; rs10971411; rs13296330; rs13287724; rs10971434; rs7850948; rs1013215; rs1013216; rs1013217; rs10738908; rs10758186; rs10813946; rs10971409; rs11787896; rs11792978; rs11998760; rs13285029; rs13288792; rs13297389; rs1556253; rs1556254; rs1887877; rs2481061; rs2481062; rs2770809; rs28612947; rs28645680; rs35172105; rs544723; rs546688; rs581450; rs589733; rs594988; rs750590; rs750591; rs750592; rs7860416; rs7863609; rs830089; rs874200; rs874202; rs943929

# Metabolic_Enzyme_17_General_References:
3144273; 2124683; 1903938; 1384956; 7579794; 7540104; 3094506; 3091013; 2120039; 1714903; 7744867; 10580128

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5968

# Metabolic_Enzyme_18_Name:
Glyceraldehyde-3-phosphate dehydrogenase

# Metabolic_Enzyme_18_Synonyms:
GAPDH

# Metabolic_Enzyme_18_Gene_Name:
GAPDH

# Metabolic_Enzyme_18_Protein_Sequence:
>Glyceraldehyde3phosphate dehydrogenase
MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTV
KAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVI
ISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHA
ITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANV
SVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAG
IALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE

# Metabolic_Enzyme_18_Number_of_Residues:
335

# Metabolic_Enzyme_18_Molecular_Weight:
36054

# Metabolic_Enzyme_18_Theoretical_pI:
8.73

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Function:  glyceraldehyde-3-phosphate dehydrogenase activity
Function:  glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_18_Specific_Function:
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH

# Metabolic_Enzyme_18_Pathway:
map00010  Glycolysis / Gluconeogenesis

# Metabolic_Enzyme_18_Reaction:
D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF02800:Gp_dh_C;
PF00044:Gp_dh_N

# Metabolic_Enzyme_18_Signals:
None

# Metabolic_Enzyme_18_Transmembrane_Regions:
None

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 1.2.1.12

# Metabolic_Enzyme_18_GenBank_ID_Protein:
31645

# Metabolic_Enzyme_18_SwissProt_ID:
G3P_HUMAN (P04406)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
GAPDH

# Metabolic_Enzyme_18_Geneatlas_id:
GAPDH

# Metabolic_Enzyme_18_hgnc_id:
HGNC:4141

# Metabolic_Enzyme_18_PDB_ID:
1J0X

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_18_Gene_Sequence:
>1008 bp
ATGGGGAAGGTGAAGGTCGGAGTCAACGGATTTGGTCGTATTGGGCGCCTGGTCACCAGG
GCTGCTTTTAACTCTGGTAAAGTGGATATTGTTGCCATCAATGACCCCTTCATTGACCTC
AACTACATGGTTTACATGTTCCAATATGATTCCACCCATGGCAAATTCCATGGCACCGTC
AAGGCTGAGAACGGGAAGCTTGTCATCAATGGAAATCCCATCACCATCTTCCAGGAGCGA
GATCCCTCCAAAATCAAGTGGGGCGATGCTGGCGCTGAGTACGTCGTGGAGTCCACTGGC
GTCTTCACCACCATGGAGAAGGCTGGGGCTCATTTGCAGGGGGGAGCCAAAAGGGTCATC
ATCTCTGCCCCCTCTGCTGATGCCCCCATGTTCGTCATGGGTGTGAACCATGAGAAGTAT
GACAACAGCCTCAAGATCATCAGCAATGCCTCCTGCACCACCAACTGCTTAGCACCCCTG
GCCAAGGTCATCCATGACAACTTTGGTATCGTGGAAGGACTCATGACCACAGTCCATGCC
ATCACTGCCACCCAGAAGACTGTGGATGGCCCCTCCGGGAAACTGTGGCGTGATGGCCGC
GGGGCTCTCCAGAACATCATCCCTGCCTCTACTGGCGCTGCCAAGGCTGTGGGCAAGGTC
ATCCCTGAGCTAGACGGGAAGCTCACTGGCATGGCCTTCCGTGTCCCCACTGCCAACGTG
TCAGTGGTGGACCTGACCTGCCGTCTAGAAAAACCTGCCAAATATGATGACATCAAGAAG
GTGGTGAAGCAGGCGTCGGAGGGCCCCCTCAAAGGCATCCTGGGCTACACTGAGCACCAG
GTGGTCTCCTCTGACTTCAACAGCGACACCCACTCCTCCACCTTTGACGCTGGGGCTGGC
ATTGCCCTCAACGACCACTTTGTCAAGCTCATTTCCTGGTATGACAACGAATTTGGCTAC
AGCAACAGGGTGGTGGACCTCATGGCCCACATGGCCTCCAAGGAGTAA

# Metabolic_Enzyme_18_GenBank_ID_Gene:
X01677

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_18_Locus:
12p13

# Metabolic_Enzyme_18_SNPs:
rs1803621; rs1065691; rs1803622; rs1136666; rs3741918; rs3741917; rs1060619; rs1060620; rs1060621; rs2886093; rs41334949; rs7971637; rs6489721; rs11549346; rs11549333; rs11549340; rs1065740; rs11549329; rs11549351; rs11549345; rs1062442; rs3211600; rs1803625; rs1062429; rs1062436; rs11549361; rs11549327; rs11549316; rs11549338; rs11549348; rs11549373; rs11549343; rs11549336; rs11549325; rs11549350; rs11549371; rs11549355; rs3203507; rs11549347; rs11266742; rs11549318; rs3211592; rs11549319; rs3199979; rs11549332; rs3741915; rs11549320; rs3211599; rs3211598; rs11552253; rs35318117; rs35043201; rs3759342; rs36015908; rs34277306; rs12425927; rs7307229; rs7977806; rs36094914; rs1043262; rs1047792; rs1063206; rs10849482; rs10849483; rs10849484; rs10849485; rs10849488; rs11064250; rs16932751; rs2072374; rs2240871; rs2240875; rs2270176; rs2270177; rs35819349; rs7132183; rs7297283; rs7300366; rs7311174; rs7316224; rs733593; rs740850; rs740851; rs740852; rs758740; rs7979706

# Metabolic_Enzyme_18_General_References:
6096136; 6096821; 2987855; 3664468; 3027061; 3170585; 1924305; 10944468; 7030790; 12665801; 7498159; 1193541; 957435

# Metabolic_Enzyme_18_References:
10911962; 11876406; 1259946; 226898

# Metabolic_Enzyme_19_ID:
6086

# Metabolic_Enzyme_19_Name:
Glucose-6-phosphate isomerase

# Metabolic_Enzyme_19_Synonyms:
GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI; Neuroleukin; NLK; Sperm antigen 36; SA-36

# Metabolic_Enzyme_19_Gene_Name:
GPI

# Metabolic_Enzyme_19_Protein_Sequence:
>Glucose6phosphate isomerase
MAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLV
TEDVMRMLVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMP
EVNKVLDKMKSFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPR
VWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVA
KHFVALSTNTTKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGA
HWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAYFQQGDMESN
GKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGL
HHKILLANFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFT
KLTPFMLGALVAMYEHKIFVQGIIWDINSFDQWGVELGKQLAKKIEPELDGSAQVTSHDA
STNGLINFIKQQREARVQ

# Metabolic_Enzyme_19_Number_of_Residues:
558

# Metabolic_Enzyme_19_Molecular_Weight:
63148

# Metabolic_Enzyme_19_Theoretical_pI:
8.55

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  catalytic activity
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, interconverting aldoses and ketoses
Function:  glucose-6-phosphate isomerase activity
 ||
>>>
Process:  glucose catabolism
Process:  glycolysis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  gluconeogenesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_19_Specific_Function:
Neuroleukin is a neurotrophic factor for spinal and sensory neurons

# Metabolic_Enzyme_19_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00030  Pentose phosphate pathway;
 map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_19_Reaction:
D-glucose 6-phosphate = D-fructose 6-phosphate

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF00342:PGI

# Metabolic_Enzyme_19_Signals:
None

# Metabolic_Enzyme_19_Transmembrane_Regions:
None

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 5.3.1.9

# Metabolic_Enzyme_19_GenBank_ID_Protein:
189238

# Metabolic_Enzyme_19_SwissProt_ID:
G6PI_HUMAN (P06744)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
GPI

# Metabolic_Enzyme_19_Geneatlas_id:
GPI

# Metabolic_Enzyme_19_hgnc_id:
HGNC:4458

# Metabolic_Enzyme_19_PDB_ID:
1NUH

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_19_Gene_Sequence:
>1677 bp
ATGGCCGCTCTCACCCGGGACCCCCAGTTCCAGAAGCTGCAGCAATGGTACCGCGAGCAC
CGCTCCGAGCTGAACCTGCGCCGCCTCTTCGATGCCAACAAGGACCGCTTCAACCACTTC
AGCTTGACCCTCAACACCAACCATGGGCATATCCTGGTGGATTACTCCAAGAACCTGGTG
ACGGAGGACGTGATGCGGATGCTGGTGGACTTGGCCAAGTCCAGGGGCGTGGAGGCCGCC
CGGGAGCGGATGTTCAATGGTGAGAAGATCAACTACACCGAGGGTCGAGCCGTGCTGCAC
GTGGCTCTGCGGAACCGGTCAAACACACCCATCCTGGTAGACGGCAAGGATGTGATGCCA
GAGGTCAACAAGGTTCTGGACAAGATGAAGTCTTTCTGCCAGCGTGTCCGGAGCGGTGAC
TGGAAGGGGTACACAGGCAAGACCATCACGGACGTCATCAACATTGGCATTGTCGGCTCC
GACCTGGGACCCCTCATGGTGACTGAAGCCCTTAAGCCATACTCTTCAGGAGGTCCCCGC
GTCTGGTATGTCTCCAACATTGATGGAACTCACATTGCCAAAACCCTGGCCCAGCTGAAC
CCGGAGTCCTCCCTGTTCATCATTGCCTCCAAGACCTTTACTACCCAGGAGACCATCACG
AATGCAGAGACGGCGAAGGAGTGGTTTCTCCAGGCGGCCAAGGATCCTTCTGCAGTGGCG
AAGCACTTTGTTGCCCTGTCTACTAACACAACCAAAGTGAAGGAGTTTGGAATTGACCCT
CAAAACATGTTCGAGTTCTGGGATTGGGTGGGAGGACGCTACTCGCTGTGGTCGGCCATC
GGACTCTCCATTGCCCTGCACGTGGGTTTTGACAACTTCGAGCAGCTGCTCTCGGGGGCT
CACTGGATGGACCAGCACTTCCGCACGACGCCCCTGGAGAAGAACGCCCCCGTCTTGCTG
GCCCTGCTGGGTATCTGGTACATCAACTGCTTTGGGTGTGAGACACACGCCATGCTGCCC
TATGACCAGTACCTGCACCGCTTTGCTGCGTACTTCCAGCAGGGCGACATGGAGTCCAAT
GGGAAATACATCACCAAATCTGGAACCCGTGTGGACCACCAGACAGGCCCCATTGTGTGG
GGGGAGCCAGGGACCAATGGCCAGCATGCTTTTTACCAGCTCATCCACCAAGGCACCAAG
ATGATACCCTGTGACTTCCTCATCCCGGTCCAGACCCAGCACCCCATACGGAAGGGTCTG
CATCACAAGATCCTCCTGGCCAACTTCTTGGCCCAGACAGAGGCCCTGATGAGGGGAAAA
TCGACGGAGGAGGCCCGAAAGGAGCTCCAGGCTGCGGGCAAGAGTCCAGAGGACCTTGAG
AGGCTGCTGCCACATAAGGTCTTTGAAGGAAATCGCCCAACCAACTCTATTGTGTTCACC
AAGCTCACACCATTCATGCTTGGAGCCTTGGTCGCCATGTATGAGCACAAGATCTTCGTT
CAGGGCATCATCTGGGACATCAACAGCTTTGACCAGTGGGGAGTGGAGCTGGGAAAGCAG
CTGGCTAAGAAAATAGAGCCTGAGCTTGATGGCAGTGCTCAAGTGACCTCTCACGACGCT
TCTACCAATGGGCTCATCAACTTCATCAAGCAGCAGCGCGAGGCCAGAGTCCAATAA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
K03515

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_19_Locus:
19q13.1

# Metabolic_Enzyme_19_SNPs:
rs8191371; rs2230294; rs1864139; rs8191382; rs1062480; rs1801015; rs8191416; rs34604585; rs2278266; rs2377572; rs7248411; rs8105184; rs8191393; rs4290576; rs8108038; rs8191381; rs8191385; rs2301263; rs8191399; rs4806015; rs8191361; rs8191425; rs3786884; rs1135465; rs7408956; rs8191378; rs8191424; rs8191372; rs8191394; rs8191410; rs8191403; rs8191364; rs8191376; rs8191426; rs8191387; rs10412725; rs8191398; rs10412410; rs8191360; rs7251297; rs10420957; rs8191412; rs8191404; rs8191419; rs8191363; rs8191390; rs2099099; rs8191389; rs8191374; rs8191392; rs8191409; rs16969249; rs8191380; rs8191400; rs10402604; rs8191377; rs11882260; rs8191396; rs8191405; rs10402237; rs8191369; rs8191414; rs7259394; rs8191362; rs11883310; rs10414598; rs11084765; rs8191368; rs8191365; rs8191386; rs8191420; rs8191406; rs7253813; rs8191397; rs8108083; rs4619515; rs8191429; rs8191356; rs7248970; rs11548996; rs11549002; rs1138409; rs1139447; rs34306618; rs11548997; rs11549000; rs11549001; rs1139454; rs11548998; rs35307979; rs8191359; rs3202337; rs1138438; rs7250027; rs34523056; rs8191421; rs12981485; rs8191379; rs10417925; rs12980831; rs4538119; rs8107867; rs8191417; rs4328566; rs8191415; rs8191428; rs4131351; rs8191367; rs8191407; rs13345182; rs8191375; rs8191418; rs35236631; rs8191411; rs8191391; rs8191373; rs8103448; rs7508474; rs8191427; rs8191388; rs8191422; rs35036655; rs10414626; rs34357963; rs12151155; rs8191395; rs12609804; rs8191408; rs10403982; rs10403178; rs3815930; rs10410400; rs11667021; rs12609887; rs7258820; rs34693694; rs8104740; rs4131352; rs11430472; rs8191384; rs8191366; rs12980826; rs8191423; rs35856824; rs8191401; rs34364440; rs8191413; rs4545937; rs10410575; rs8191383; rs35979967; rs35528136; rs35716159; rs28609064; rs4355042; rs4131353; rs34872723; rs8110617; rs35852790; rs35137793; rs36041853; rs11670783; rs8191402; rs12608465; rs34158809; rs35580817; rs2016292; rs10671976; rs36206350; rs10408512; rs12979474; rs36206349; rs34098176; rs8191358; rs10411051; rs12609911; rs1465432; rs1559195; rs1862489; rs2161473; rs2217327; rs416602; rs422732; rs580391

# Metabolic_Enzyme_19_General_References:
10727272; 2387591; 3352745; 8499925; 7989588; 8822952; 8822954; 9446754; 9856489

# Metabolic_Enzyme_19_References:
10206659; 11030090; 1247593; 16375918

# Metabolic_Enzyme_20_ID:
6037

# Metabolic_Enzyme_20_Name:
6-phosphofructokinase, muscle type

# Metabolic_Enzyme_20_Synonyms:
Phosphofructokinase 1; Phosphohexokinase; Phosphofructo-1-kinase isozyme A; PFK-A; Phosphofructokinase-M

# Metabolic_Enzyme_20_Gene_Name:
PFKM

# Metabolic_Enzyme_20_Protein_Sequence:
>6phosphofructokinase, muscle type
MTHEEHHAAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVD
GGDHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDG
SLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDS
ALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWE
EHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQ
RGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTK
AMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRPPVSKSGSHTVAVMNVGAPAAGMNAAVR
STVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQ
ISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSV
GADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPF
TIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLG
HMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVF
QPVAELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKRSGEAAV


# Metabolic_Enzyme_20_Number_of_Residues:
780

# Metabolic_Enzyme_20_Molecular_Weight:
85184

# Metabolic_Enzyme_20_Theoretical_pI:
8.07

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  phosphofructokinase activity
Function:  6-phosphofructokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  protein complex
Component:  6-phosphofructokinase complex
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_20_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_20_Specific_Function:
ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

# Metabolic_Enzyme_20_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00030  Pentose phosphate pathway;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism

# Metabolic_Enzyme_20_Reaction:
ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00365:PFK

# Metabolic_Enzyme_20_Signals:
None

# Metabolic_Enzyme_20_Transmembrane_Regions:
None

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 2.7.1.11

# Metabolic_Enzyme_20_GenBank_ID_Protein:
1101758

# Metabolic_Enzyme_20_SwissProt_ID:
K6PF_HUMAN (P08237)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
PFKM

# Metabolic_Enzyme_20_Geneatlas_id:
PFKM

# Metabolic_Enzyme_20_hgnc_id:
HGNC:8877

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Not Available

# Metabolic_Enzyme_20_Gene_Sequence:
>2343 bp
ATGACCCATGAAGAGCACCATGCAGCCAAAACCCTGGGGATTGGCAAAGCCATTGCTGTC
TTAACCTCTGGTGGAGATGCCCAAGGTATGAATGCTGCTGTCAGGGCTGTGGTTCGAGTT
GGTATCTTCACCGGTGCCCGTGTCTTCTTTGTCCATGAGGGTTATCAAGGCCTGGTGGAT
GGTGGAGATCACATCAAGGAAGCCACCTGGGAGAGCGTTTCGATGATGCTTCAGCTGGGA
GGCACGGTGATTGGAAGTGCCCGGTGCAAGGACTTTCGGGAACGAGAAGGACGACTCCGA
GCTGCCTACAACCTGGTGAAGCGTGGGATCACCAATCTCTGTGTCATTGGGGGTGATGGC
AGCCTCACTGGGGCTGACACCTTCCGTTCTGAGTGGAGTGACTTGTTGAGTGACCTCCAG
AAAGCAGGTAAGATCACAGATGAGGAGGCTACGAAGTCCAGCTACCTGAACATTGTGGGC
CTGGTTGGGTCAATTGACAATGACTTCTGTGGCACTGATATGACCATTGGCACTGACTCT
GCCCTGCATCGGATCATGGAAATTGTAGATGCCATCACTACCACTGCCCAGAGCCACCAG
AGGACATTTGTGTTAGAAGTAATGGGCCGCCACTGTGGATACCTGGCCCTTGTCACCTCT
CTGTCCTGTGGGGCCGACTGGGTTTTTATTCCTGAATGTCCACCAGATGACGACTGGGAG
GAACACCTTTGTCGCCGACTCAGCGAGACAAGGACCCGTGGTTCTCGTCTCAACATCATC
ATTGTGGCTGAGGGTGCAATTGACAAGAATGGAAAACCAATCACCTCAGAAGACATCAAG
AATCTGGTGGTTAAGCGTCTGGGATATGACACCCGGGTTACTGTCTTGGGGCATGTGCAG
AGGGGTGGGACGCCATCAGCCTTTGACAGAATTCTGGGCAGCAGGATGGGTGTGGAAGCA
GTGATGGCACTTTTGGAGGGGACCCCAGATACCCCAGCCTGTGTAGTGAGCCTCTCTGGT
AACCAGGCTGTGCGCCTGCCCCTCATGGAATGTGTCCAGGTGACCAAAGATGTGACCAAG
GCCATGGATGAGAAGAAATTTGACGAAGCCCTGAAGCTGAGAGGCCGGAGCTTCATGAAC
AACTGGGAGGTGTACAAGCTTCTAGCTCATGTCAGACCCCCGGTATCTAAGAGTGGTTCG
CACACAGTGGCTGTGATGAACGTGGGGGCTCCGGCTGCAGGCATGAATGCTGCTGTTCGC
TCCACTGTGAGGATTGGCCTTATCCAGGGCAACCGAGTGCTCGTTGTCCATGATGGTTTC
GAGGGCCTGGCCAAGGGGCAGATAGAGGAAGCTGGCTGGAGCTATGTTGGGGGCTGGACT
GGCCAAGGTGGCTCTAAACTTGGGACTAAAAGGACTCTACCCAAGAAGAGCTTTGAACAG
ATCAGTGCCAATATAACTAAGTTTAACATTCAGGGCCTTGTCATCATTGGGGGCTTTGAG
GCTTACACAGGGGGCCTGGAACTGATGGAGGGCAGGAAGCAGTTTGATGAGCTCTGCATC
CCATTTGTGGTCATTCCTGCTACAGTCTCCAACAATGTCCCTGGCTCAGACTTCAGCGTT
GGGGCTGACACAGCACTCAATACTATCTGCACAACCTGTGACCGCATCAAGCAGTCAGCA
GCTGGCACCAAGCGTCGGGTGTTTATCATTGAGACTATGGGTGGCTACTGTGGCTACCTG
GCTACCATGGCTGGACTGGCAGCTGGGGCCGATGCTGCCTACATTTTTGAGGAGCCCTTC
ACCATTCGAGACCTGCAGGCAAATGTTGAACATCTGGTGCAAAAGATGAAAACAACTGTG
AAAAGGGGCTTGGTGTTAAGGAATGAAAAGTGCAATGAGAACTATACCACTGACTTCATT
TTCAACCTGTACTCTGAGGAGGGGAAGGGCATCTTCGACAGCAGGAAGAATGTGCTTGGT
CACATGCAGCAGGGTGGGAGCCCAACCCCATTTGATAGGAATTTTGCCACTAAGATGGGC
GCCAAGGCTATGAACTGGATGTCTGGGAAAATCAAAGAGAGTTACCGTAATGGGCGGATC
TTTGCCAATACTCCAGATTCGGGCTGTGTTCTGGGGATGCGTAAGAGGGCTCTGGTCTTC
CAACCAGTGGCTGAGCTGAAGGACCAGACAGATTTTGAGCATCGAATCCCCAAGGAACAG
TGGTGGCTGAAACTGAGGCCCATCCTCAAAATCCTAGCCAAGTACGAGATTGACTTGGAC
ACTTCAGACCATGCCCACCTGGAGCACATCACCCGGAAGCGGTCCGGGGAAGCTGCCGTC
TAA

# Metabolic_Enzyme_20_GenBank_ID_Gene:
M59741

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_20_Locus:
12q13.3

# Metabolic_Enzyme_20_SNPs:
rs2228500; rs8716; rs1049392; rs1859445; rs1476607; rs4760685; rs4075913; rs2286020; rs4760684; rs10875747; rs2286021; rs11168421; rs10082861; rs4141065; rs2269933; rs10875749; rs10875746; rs12304251; rs10219645; rs11168424; rs11168423; rs7484648; rs10875748; rs11168427; rs11830546; rs11168425; rs10219623; rs11168419; rs4760683; rs10875745; rs11168417; rs2269935; rs11168418; rs11168420; rs11552506; rs41291965; rs12828446; rs41291971; rs12826853; rs12317430; rs41290390; rs11552507; rs14683; rs3189641; rs8977; rs35847394; rs11374838; rs34737106; rs12817932; rs41291969; rs12826678; rs34747961; rs34241029; rs36015571; rs3989535; rs11168422; rs11609979; rs12826680; rs34700912; rs33914383; rs7978674; rs41291963; rs7301375; rs12831427; rs41291961; rs41291967; rs34996435; rs34207745; rs4075914; rs35651820; rs11835145; rs7133146; rs10219520; rs10783230; rs10875750; rs11168413; rs11168414; rs11168428; rs11608670; rs12297470; rs12310813; rs12422786; rs12579815; rs1802781; rs3936179; rs4760682; rs4760686; rs7302354; rs7485355; rs7488265; rs8804

# Metabolic_Enzyme_20_General_References:
1833270; 2526045; 2822475; 2140567; 2526044; 7550225; 7513946; 7825568; 8889589

# Metabolic_Enzyme_20_References:
10900132; 1112805; 11300795; 123467

# Metabolic_Enzyme_21_ID:
6079

# Metabolic_Enzyme_21_Name:
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

# Metabolic_Enzyme_21_Synonyms:
6PF-2-K/Fru- 2,6-P2ASE liver isozyme[Includes: 6-phosphofructo-2-kinase

# Metabolic_Enzyme_21_Gene_Name:
PFKFB1

# Metabolic_Enzyme_21_Protein_Sequence:
>6phosphofructo2kinase/fructose2,6biphosphatase 1
MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYIST
KLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYL
SHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPD
YIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRT
VYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLK
VWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRY
RYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLH
TVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY

# Metabolic_Enzyme_21_Number_of_Residues:
471

# Metabolic_Enzyme_21_Molecular_Weight:
54682

# Metabolic_Enzyme_21_Theoretical_pI:
6.56

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  fructose metabolism
Process:  fructose 2,6-bisphosphate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_21_Specific_Function:
Synthesis and degradation of fructose 2,6-bisphosphate

# Metabolic_Enzyme_21_Pathway:
map00051  Fructose and mannose metabolism

# Metabolic_Enzyme_21_Reaction:
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF01591:6PF2K;
PF00300:PGAM

# Metabolic_Enzyme_21_Signals:
None

# Metabolic_Enzyme_21_Transmembrane_Regions:
None

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 2.7.1.105;EC 3.1.3.46

# Metabolic_Enzyme_21_GenBank_ID_Protein:
35503

# Metabolic_Enzyme_21_SwissProt_ID:
F261_HUMAN (P16118)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
PFKFB1

# Metabolic_Enzyme_21_Geneatlas_id:
PFKFB1

# Metabolic_Enzyme_21_hgnc_id:
HGNC:8872

# Metabolic_Enzyme_21_PDB_ID:
1K6M

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Not Available

# Metabolic_Enzyme_21_Gene_Sequence:
>1416 bp
ATGTCTCCAGAGATGGGAGAGCTCACCCAAACCAGGTTGCAGAAGATCTGGATTCCACAC
AGCAGCGGCAGCAGCAGGCTGCAACGGAGAAGGGGCTCATCCATACCCCAGTTTACCAAT
TCCCCCACAATGGTGATCATGGTGGGTTTACCAGCTCGAGGCAAGACCTATATCTCCACA
AAGCTCACACGATATCTCAACTGGATAGGAACACCAACTAAAGTGTTTAATTTAGGCCAG
TATCGACGAGAGGCAGTGAGCTACAAGAACTATGAATTCTTTCTTCCAGACAACATGGAA
GCCCTGCAAATCAGGAAGCAGTGCGCCCTGGCAGCCCTGAAGGATGTTCACAACTATCTC
AGCCATGAGGAAGGTCATGTTGCGGTTTTTGATGCCACCAACACTACCAGAGAACGACGG
TCACTGATCCTGCAGTTTGCAAAAGAACATGGTTACAAGGTGTTTTTCATTGAGTCCATT
TGTAATGACCCTGGCATAATTGCAGAAAACATCAGGCAAGTGAAACTTGGCAGCCCTGAT
TATATAGACTGTGACCGGGAAAAGGTTCTGGAAGACTTTCTAAAGAGAATTGAGTGCTAT
GAGGTCAACTACCAACCCTTGGATGAGGAACTGGACAGCCACCTGTCCTACATCAAGATC
TTCGACGTGGGCACACGCTACATGGTGAACCGAGTGCAGGATCACATCCAGAGCCGCACA
GTCTACTACCTCATGAATATCCATGTCACACCTCGCTCCATCTACCTTTGCCGACATGGC
GAGAGTGAACTCAACATCAGAGGCCGCATCGGAGGTGACTCTGGCCTCTCAGTTCGCGGC
AAGCAGTATGCCTATGCCCTGGCCAACTTCATTCAGTCCCAGGGCATCAGCTCCCTGAAG
GTGTGGACCAGTCGCATGAAGAGGACCATCCAGACAGCTGAGGCCCTGGGTGTCCCCTAT
GAGCAGTGGAAGGCCCTGAATGAGATTGATGCGGGTGTCTGTGAGGAGATGACCTATGAA
GAAATCCAGGAACATTACCCTGAAGAATTTGCACTGCGAGACCAAGATAAATATCGCTAC
CGCTATCCCAAGGGAGAGTCCTATGAGGATCTGGTTCAGCGTCTGGAGCCAGTGATAATG
GAGCTAGAACGACAGGAGAATGTACTGGTGATCTGCCACCAGGCTGTCATGCGGTGCCTC
CTGGCCTATTTCCTGGATAAAAGTTCAGATGAGCTTCCATATCTCAAGTGCCCTCTGCAC
ACAGTGCTCAAACTCACTCCTGTGGCTTATGGCTGCAAAGTGGAATCCATCTACCTGAAT
GTGGAGGCCGTGAACACACACCGGGAGAAGCCTGAGAATGTGGACATCACCCGGGAACCT
GAGGAAGCCCTGGATACTGTCCCAGCCCACTACTGA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
X52638

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_21_Locus:
Xp11.21

# Metabolic_Enzyme_21_SNPs:
rs2885192; rs2005463; rs7054008; rs12009826; rs4826364; rs12013180; rs7055550; rs7876830; rs3765479; rs7884892; rs12006688; rs6521221; rs7877193; rs4592165; rs12010055; rs12009992; rs12014660; rs7050286; rs4826365; rs6521220; rs742049; rs12392887; rs12007444; rs12009010; rs6611392; rs5960384; rs6612244; rs12012208; rs7055905; rs1122799; rs12014943; rs7058302; rs7058322; rs7058927; rs6612249; rs5914242; rs1042227; rs34371591; rs5960058; rs36040294; rs36000310; rs6611394; rs6611393; rs41300640; rs12171770; rs5960059; rs11423589; rs4421487; rs35672261; rs35602727; rs11396018; rs11396019; rs35995915; rs34911422; rs3028350; rs35636472; rs41306753; rs5960383; rs34428777; rs5960057; rs12842941; rs6612245; rs35611718; rs34224076; rs34971789; rs6612246; rs12844500; rs6651976; rs1054247; rs6612247; rs12389586; rs34692314; rs5902532; rs12834442; rs41306890; rs34059559; rs35766066; rs35051444; rs12006936; rs34676173; rs34539636; rs36018524; rs34913653; rs5960382; rs41300642; rs34339145; rs34442347; rs5902531; rs12836233; rs5914243; rs12862038; rs35325903; rs34995115; rs12171767; rs12833908; rs5960056; rs34495378; rs13440561; rs13440562; rs10218054; rs35134458; rs1008681; rs10284089; rs1050010; rs1050011; rs12851962; rs1811845; rs1883158; rs2273138; rs2301416; rs2301417; rs3180303; rs3180304; rs4490972; rs4826363; rs5960055; rs7059574; rs7062848; rs7889977; rs7891167

# Metabolic_Enzyme_21_General_References:
2163524; 2837207

# Metabolic_Enzyme_21_References:
1311308; 1323462; 16316985; 2969730

# Metabolic_Enzyme_22_ID:
6085

# Metabolic_Enzyme_22_Name:
Transketolase

# Metabolic_Enzyme_22_Synonyms:
TK

# Metabolic_Enzyme_22_Gene_Name:
TKT

# Metabolic_Enzyme_22_Protein_Sequence:
>Transketolase
MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKS
QDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDV
ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA
ILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIA
KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN
IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFI
ECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVS
IGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII
YNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPL
DRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAE
LLKMFGIDRDAIAQAVRGLITKA

# Metabolic_Enzyme_22_Number_of_Residues:
623

# Metabolic_Enzyme_22_Molecular_Weight:
67878

# Metabolic_Enzyme_22_Theoretical_pI:
7.73

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring aldehyde or ketonic groups
Function:  transketolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_22_Specific_Function:
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

# Metabolic_Enzyme_22_Pathway:
map00030  Pentose phosphate pathway;
 map00710  Carbon fixation;
 map01051  Biosynthesis of ansamycins

# Metabolic_Enzyme_22_Reaction:
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF02779:Transket_pyr;
PF02780:Transketolase_C;
PF00456:Transketolase_N

# Metabolic_Enzyme_22_Signals:
None

# Metabolic_Enzyme_22_Transmembrane_Regions:
None

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 2.2.1.1

# Metabolic_Enzyme_22_GenBank_ID_Protein:
37267

# Metabolic_Enzyme_22_SwissProt_ID:
TKT_HUMAN (P29401)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
TKT

# Metabolic_Enzyme_22_Geneatlas_id:
TKT

# Metabolic_Enzyme_22_hgnc_id:
HGNC:11834

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Not Available

# Metabolic_Enzyme_22_Gene_Sequence:
>1872 bp
ATGGAGAGCTACCACAAGCCTGACCAGCAGAAGCTGCAGGCCTTGAAGGACACGGCCAAC
CGCCTACGTATCAGCTCCATCCAGGCCTCCTCTGCGGCGGGCTCTGGCCACCCCACGTCA
TGCTGCAGCGCCGCAGTGATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTCC
CAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCC
ATCCTCTACGCGGTCTGGGCTGAAGCTGGTTTCCTGGCCGAGGCGGAGCTGCTGAACCTG
AGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGTG
GCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAA
TACTTCGACAAGGCCAGCTACCGAGTCTATTGCTTGCTGGGAGATGGGGAGCTGTCAGAG
GGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGCC
ATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCGCTGCAGCACCAGATGGAC
ATCTACCAGAAGCGGTGCGAGGCCTTCGGTTGGCATGCCATCATCGTGGATGGACACAGC
GTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGCC
AAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAG
CCCCTCCCCAAAAACATGGCTGAGCAGATCATCCAGGAGATCTACAGCCAGATCCAGAGC
AAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAAC
ATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCC
TACGGGCAGGCACTGGCCAAGCTGGGCCATGCCAGTGACCGCATCATCGCCCTGGATGGG
GACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCATC
GAGTGCTACATTGCCGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAAC
AGGACGGTGCCCTTCTGCAGCACTTTTGCAGCCTTCTTCACGCGGGCCTTTGACCAGATT
CGCATGGCGGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTCC
ATCGGGGAAGACGGGGCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTC
CCCACATCAACTGTCTTTTACCCAAGTGATGGCGTTGCTACAGAGAAGGCAGTGGAACTA
GCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCATC
TATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGAT
GACCAGGTGACCGTTATCGGGGCTGGGGTGACCCTGCACGAGGCCTTGGCCGCTGCCGAA
CTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCTG
GACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAG
GACCATTATTATGAAGGTGGCATTGGTGAGGCTGTGTCCAGTGCAGTAGTGGGCGAGCCT
GGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCAGCTGAG
CTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATC
ACCAAGGCCTAG

# Metabolic_Enzyme_22_GenBank_ID_Gene:
X67688

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_22_Locus:
3p14.3

# Metabolic_Enzyme_22_SNPs:
rs17052920; rs3163; rs6785374; rs1051485; rs1051483; rs2035450; rs4267636; rs4687715; rs6768738; rs900494; rs3773745; rs10433616; rs968702; rs7628245; rs7633598; rs12493802; rs7650103; rs7610113; rs3773747; rs7633966; rs11720625; rs2306569; rs4687717; rs9850440; rs6787685; rs3773743; rs2279323; rs735940; rs9827244; rs7356056; rs11717767; rs2242301; rs3821691; rs17234092; rs11717712; rs3736154; rs2279321; rs9879195; rs3736153; rs3773742; rs12487632; rs728910; rs9820968; rs7631667; rs3816767; rs7649481; rs7647720; rs2358621; rs9858133; rs12630643; rs9864057; rs9284890; rs3773739; rs3773746; rs7609596; rs2242302; rs3736156; rs7627444; rs7640493; rs7617474; rs6445573; rs2242303; rs11130362; rs12635973; rs2279322; rs9846315; rs3773740; rs12629909; rs7646760; rs2242300; rs4687718; rs12633001; rs2884495; rs6793773; rs9826552; rs4687716; rs9820979; rs2279320; rs3773744; rs9858502; rs7625237; rs7630632; rs9830594; rs1545857; rs6782597; rs2077693; rs12494824; rs9818458; rs12487568; rs10433618; rs6793684; rs11719464; rs10433617; rs13101181; rs13075304; rs7612011; rs9311494; rs12633000; rs12485313; rs3736155; rs2242304; rs6445572; rs13074156; rs3773741; rs11130365; rs12632671; rs3736151; rs17306163; rs17030933; rs13093936; rs34466346; rs3162; rs11556003; rs11556004; rs4687714; rs1802929; rs11556002; rs11556006; rs41275537; rs34601275; rs2229693; rs1140826; rs1140825; rs11305678; rs35203736; rs12638638; rs34084206; rs11130364; rs9835964; rs10620591; rs34995533; rs35075155; rs10703271; rs35048890; rs10212420; rs34310421; rs41275543; rs2358620; rs7356096; rs6786157; rs34089717; rs10666288; rs13091081; rs10668063; rs35041022; rs12054426; rs28758191; rs34095201; rs9850314; rs1351703; rs35712428; rs41389846; rs35495179; rs35643056; rs34243738; rs5848979; rs5848978; rs12629312; rs7430638; rs35154296; rs9875011; rs9859430; rs41275539; rs35936646; rs9830895; rs34146825; rs13059189; rs7626730; rs35171987; rs10049441; rs35205801; rs34618710; rs35246063; rs41275541; rs3821692; rs33924283; rs41275535; rs41332244; rs3075727; rs34276819; rs35110726; rs9868820; rs35794580; rs34107310; rs34838231; rs7431404; rs11297416; rs3075723; rs9833188; rs10622320; rs9858049; rs1056082; rs3832231; rs1056076; rs35706165; rs1056083; rs9681418; rs35261010; rs11540529; rs11540530; rs17030930; rs17030934; rs11130358; rs11130367; rs11919567; rs12490667; rs12633545; rs12634987; rs13317770; rs17052954; rs17052957; rs1979491; rs34774173; rs4687573; rs6773409; rs6781629; rs7631103; rs7637556; rs7637934; rs7641951; rs7647990; rs7648309; rs931253; rs9852398

# Metabolic_Enzyme_22_General_References:
8419340; 12665801; 1567394

# Metabolic_Enzyme_22_References:
16657791; 3768044; 8357848

# Metabolic_Enzyme_23_ID:
6082

# Metabolic_Enzyme_23_Name:
Transaldolase

# Metabolic_Enzyme_23_Synonyms:
Not Available

# Metabolic_Enzyme_23_Gene_Name:
TALDO1

# Metabolic_Enzyme_23_Protein_Sequence:
>Transaldolase
MSSSPVKRQRMESALDQLKQFTTVVADTGDFHAIDEYKPQDATTNPSLILAAAQMPAYQE
LVEEAIAYGRKLGGSQEDQIKNAIDKLFVLFGAEILKKIPGRVSTEVDARLSFDKDAMVA
RARRLIELYKEAGISKDRILIKLSSTWEGIQAGKELEEQHGIHCNMTLLFSFAQAVACAE
AGVTLISPFVGRILDWHVANTDKKSYEPLEDPGVKSVTKIYNYYKKFSYKTIVMGASFRN
TGEIKALAGCDFLTISPKLLGELLQDNAKLVPVLSAKAAQASDLEKIHLDEKSFRWLHNE
DQMAVEKLSDGIRKFAADAVKLERMLTERMFNAENGK

# Metabolic_Enzyme_23_Number_of_Residues:
337

# Metabolic_Enzyme_23_Molecular_Weight:
37540

# Metabolic_Enzyme_23_Theoretical_pI:
6.80

# Metabolic_Enzyme_23_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring aldehyde or ketonic groups
Function:  transaldolase activity
 ||
>>>
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  pentose-phosphate shunt
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_23_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_23_Specific_Function:
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway

# Metabolic_Enzyme_23_Pathway:
map00030  Pentose phosphate pathway

# Metabolic_Enzyme_23_Reaction:
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF00923:Transaldolase

# Metabolic_Enzyme_23_Signals:
None

# Metabolic_Enzyme_23_Transmembrane_Regions:
None

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 2.2.1.2

# Metabolic_Enzyme_23_GenBank_ID_Protein:
2073541

# Metabolic_Enzyme_23_SwissProt_ID:
TALDO_HUMAN (P37837)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
TALDO1

# Metabolic_Enzyme_23_Geneatlas_id:
TALDO1

# Metabolic_Enzyme_23_hgnc_id:
HGNC:11559

# Metabolic_Enzyme_23_PDB_ID:
1F05

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Cytoplasm (Probable)

# Metabolic_Enzyme_23_Gene_Sequence:
>1014 bp
ATGTCGAGCTCACCCGTGAAGCGTCAGAGGATGGAGTCCGCGCTGGACCAGCTCAAGCAG
TTCACCACCGTGGTGGCCGACACGGGCGACTTCCACGCCATCGACGAGTACAAGCCCCAG
GATGCTACCACCAACCCGTCCCTGATCCTGGCCGCAGCACAGATGCCCGCTTACCAGGAG
CTGGTGGAGGAGGCGATTGCCTATGGCCGGAAGCTGGGCGGGTCACAAGAGGACCAGATT
AAAAATGCTATTGATAAACTTTTTGTGTTGTTTGGAGCAGAAATACTAAAGAAGATTCCG
GGCCGAGTATCCACAGAAGTAGACGCAAGGCTCTCCTTTGATAAAGATGCGATGGTGGCC
AGAGCCAGGCGGCTCATCGAGCTCTACAAGGAAGCTGGGATCAGCAAGGACCGAATTCTT
ATAAAGCTGTCATCAACCTGGGAAGGAATTCAGGCTGGAAAGGAGCTCGAGGAGCAGCAC
GGCATCCACTGCAACATGACGTTACTCTTCTCCTTCGCCCAGGCTGTGGCCTGTGCCGAG
GCGGGTGTGACCCTCATCTCCCCATTTGTTGGGCGCATCCTTGATTGGCATGTGGCAAAC
ACCGACAAGAAATCCTATGAGCCCCTGGAAGACCCTGGGGTAAAGAGTGTCACTAAAATC
TACAACTACTACAAGAAGTTTAGCTACAAAACCATTGTCATGGGCGCCTCCTTCCGCAAC
ACGGGCGAGATCAAAGCACTGGCCGGCTGTGACTTCCTCACCATCTCACCCAAGCTCCTG
GGAGAGCTGCTGCAGGACAACGCCAAGCTGGTGCCTGTGCTCTCAGCCAAGGCGGCCCAA
GCCAGTGACCTGGAAAAAATCCACCTGGATGAGAAGTCTTTCCGTTGGTTGCACAACGAG
GACCAGATGGCTGTGGAGAAGCTCTCTGACGGGATCCGCAAGTTTGCCGCTGATGCAGTG
AAGCTGGAGCGGATGCTGACAGAACGAATGTTCAATGCAGAGAATGGAAAGTAG

# Metabolic_Enzyme_23_GenBank_ID_Gene:
L19437

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_23_Locus:
11p15.5-p15.4

# Metabolic_Enzyme_23_SNPs:
rs3901233; rs7122767; rs7945912; rs3895063; rs4963163; rs7478765; rs9795013; rs11246300; rs9795064; rs3891028; rs11824894; rs7949508; rs11246302; rs7924831; rs4963124; rs7936322; rs10794338; rs2075545; rs1804555; rs11302; rs1804554; rs11550601; rs11550602; rs2234021; rs11550604; rs17850536; rs1050401; rs1131125; rs7939103; rs1131117; rs1804553; rs35677629; rs3932434; rs11246303; rs34225557; rs28793893; rs3891029; rs5789192; rs35873674; rs35787553; rs11246304; rs35714164; rs34361589; rs3891031; rs11246306; rs7927798; rs28842814; rs11246305; rs35724844; rs34721664; rs4083369; rs35736011; rs4083368; rs34103509; rs11246301; rs33944124; rs4083366; rs35377964; rs3929634; rs2234023; rs34347523; rs4083367; rs3891030; rs28455833; rs4083365; rs2234022; rs34220498; rs7933290; rs10794337; rs10902218; rs11246299; rs11502190; rs11502191; rs11602009; rs11823172; rs4963160; rs4963161; rs7930569; rs7937869; rs7952095

# Metabolic_Enzyme_23_General_References:
8300619; 9339383; 9524206; 10702296; 11283793

# Metabolic_Enzyme_23_References:
13762870; 8100713; 8357848

# Metabolic_Enzyme_24_ID:
5448

# Metabolic_Enzyme_24_Name:
Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1

# Metabolic_Enzyme_24_Synonyms:
Hexosephosphate aminotransferase 1; D-fructose-6- phosphate amidotransferase 1; GFAT 1; GFAT1

# Metabolic_Enzyme_24_Gene_Name:
GFPT1

# Metabolic_Enzyme_24_Protein_Sequence:
>Glucosaminefructose6phosphate aminotransferase isomerizing 1
MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWEANACKIQLI
KKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIV
IHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQ
LEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTRW
GSQGERGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVA
AVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRG
RVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELAS
DFLDRNTPVFRDDVCFFLSQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGV
HINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLS
MDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLAL
VDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVD
CLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE

# Metabolic_Enzyme_24_Number_of_Residues:
699

# Metabolic_Enzyme_24_Molecular_Weight:
78808

# Metabolic_Enzyme_24_Theoretical_pI:
7.11

# Metabolic_Enzyme_24_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
Function:  glutamine-fructose-6-phosphate transaminase (isomerizing) activity
 ||
>>>
Process:  carbohydrate metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  carbohydrate biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_24_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_24_Specific_Function:
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins

# Metabolic_Enzyme_24_Pathway:
map00251  Glutamate metabolism;
 map00530  Aminosugars metabolism

# Metabolic_Enzyme_24_Reaction:
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate

# Metabolic_Enzyme_24_Pfam_Domain_Function:
PF00310:GATase_2;
PF01380:SIS

# Metabolic_Enzyme_24_Signals:
None

# Metabolic_Enzyme_24_Transmembrane_Regions:
None

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 2.6.1.16

# Metabolic_Enzyme_24_GenBank_ID_Protein:
183082

# Metabolic_Enzyme_24_SwissProt_ID:
GFPT1_HUMAN (Q06210)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
GFPT1

# Metabolic_Enzyme_24_Geneatlas_id:
GFPT1

# Metabolic_Enzyme_24_hgnc_id:
HGNC:4241

# Metabolic_Enzyme_24_PDB_ID:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Not Available

# Metabolic_Enzyme_24_Gene_Sequence:
>2046 bp
ATGTGTGGTATATTTGCTTACTTAAACTACCATGTTCCTCGAACGAGACGAGAAATCCTG
GAGACCCTAATCAAAGGCCTTCAGAGACTGGAGTACAGAGGATATGATTCTGCTGGTGTG
GGATTTGATGGAGGCAATGATAAAGATTGGGAAGCCAATGCCTGCAAAACCCAGCTTATT
AAGAAGAAAGGAAAAGTTAAGGCACTGGATGAAGAAGTTCACAAGCAACAAGATATGGAT
TTGGATATAGAATTTGATGTACACCTTGGAATAGCTCATACCCGTTGGGCAACACATGGA
GAACCCAGTCCTGTCAATAGCCACCCCCAGCGCTCTGATAAAAATAATGAATTTATCGTT
ATTCACAATGGAATCATCACCAACTACAAAGACTTGAAAAAGTTTTTGGAAAGCAAAGGC
TATGACTTCGAATCTGAAACAGACACAGAGACAATTGCCAAGCTCGTTAAGTATATGTAT
GACAATCGGGAAAGTCAAGATACCAGCTTTACTACCTTGGTGGAGAGAGTTATCCAACAA
TTGGAAGGTGCTTTTGCACTTGTGTTTAAAAGTGTTCATTTTCCCGGGCAAGCAGTTGGC
ACAAGGCGAGGTAGCCCTCTGTTGATTGGTGTACGGAGTGAACATAAACTTTCTACTGAT
CACATTCCTATACTCTACAGAACAGGCAAAGACAAGAAAGGAAGCTGCAATCTCTCTCGT
GTGGACAGCACAACCTGCCTTTTCCCGGTGGAAGAAAAAGCAGTGGAGTATTACTTTGCT
TCTGATGCAAGTGCTGTCATAGAACACACCAATCGCGTCATCTTTCTGGAAGATGATGAT
GTTGCAGCAGTAGTGGATGGACGTCTTTCTATCCATCGAATTAAACGAACTGCAGGAGAT
CACCCCGGACGAGCTGTGCAAACACTCCAGATGGAACTCCAGCAGATCATGAAGGGCAAC
TTCAGTTCATTTATGCAGAAGGAAATATTTGAGCAGCCAGAGTCTGTCGTGAACACAATG
AGAGGAAGAGTCAACTTTGATGACTATACTGTGAATTTGGGTGGTTTGAAGGATCACATA
AAGGAGATCCAGAGATGCCGGCGTTTGATTCTTATTGCTTGTGGAACAAGTTACCATGCT
GGTGTAGCAACACGTCAAGTTCTTGAGGAGCTGACTGAGTTGCCTGTGATGGTGGAACTA
GCAAGTGACTTCCTGGACAGAAACACACCAGTCTTTCGAGATGATGTTTGCTTTTTCCTT
AGTCAATCAGGTGAGACAGCAGATACTTTGATGGGTCTTCGTTACTGTAAGGAGAGAGGA
GCTTTAACTGTGGGGATCACAAACACAGTTGGCAGTTCCATATCACGGGAGACAGATTGT
GGAGTTCATATTAATGCTGGTCCTGAGATTGGTGTGGCCAGTACAAAGGCTTATACCAGC
CAGTTTGTATCCCTTGTGATGTTTGCCCTTATGATGTGTGATGATCGGATCTCCATGCAA
GAAAGACGCAAAGAGATCATGCTTGGATTGAAACGGCTGCCTGATTTGATTAAGGAAGTA
CTGAGCATGGATGACGAAATTCAGAAACTAGCAACAGAACTTTATCATCAGAAGTCAGTT
CTGATAATGGGACGAGGCTATCATTATGCTACTTGTCTTGAAGGGGCACTGAAAATCAAA
GAAATTACTTATATGCACTCTGAAGGCATCCTTGCTGGTGAATTGAAACATGGCCCTCTG
GCTTTGGTGGATAAATTGATGCCTGTGATCATGATCATCATGAGAGATCACACTTATGCC
AAGTGTCAGAATGCTCTTCAGCAAGTGGTTGCTCGGCAGGGGCGGCCTGTGGTAATTTGT
GATAAGGAGGATACTGAGACCATTAAGAACACAAAAAGAACGATCAAGGTGCCCCACTCA
GTGGACTGCTTGCAGGGCATTCTCAGCGTGATCCCTTTACAGTTGCTGGCTTTCCACCTT
GCTGTGCTGAGAGGCTATGATGTTGATTTCCCACGGAATCTTGCCAAATCTGTGACTGTA
GAGTGA

# Metabolic_Enzyme_24_GenBank_ID_Gene:
M90516

# Metabolic_Enzyme_24_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_24_Locus:
2p13

# Metabolic_Enzyme_24_SNPs:
rs17312042; rs2667; rs4546050; rs6546505; rs4447647; rs4549136; rs6546503; rs4369907; rs5013338; rs4340572; rs6546509; rs6722492; rs4416261; rs7571096; rs6546510; rs4078089; rs4625963; rs6747247; rs6724567; rs6728752; rs4452195; rs7578692; rs4524165; rs6757629; rs4592895; rs4428054; rs6713705; rs13419122; rs6742733; rs7579556; rs11887344; rs6705452; rs12713677; rs6720415; rs4410327; rs6738707; rs10164798; rs10195277; rs7424361; rs4473430; rs6755522; rs6705460; rs12473304; rs6546504; rs7579871; rs10167510; rs6753031; rs10200376; rs7589430; rs6725340; rs6546508; rs6713769; rs6747567; rs4479469; rs11883756; rs10170655; rs7607351; rs7578988; rs13394686; rs6728202; rs13422656; rs7596845; rs12613765; rs12466648; rs6724874; rs13429805; rs10172351; rs7592803; rs7596544; rs6747389; rs4410328; rs7558839; rs4353693; rs6727392; rs9808023; rs6546511; rs10198171; rs10198150; rs35703185; rs17854372; rs1803646; rs6729690; rs13000879; rs34022306; rs35228072; rs13406505; rs7340311; rs11486522; rs13394893; rs35072608; rs34318105; rs9678510; rs34621378; rs10191300; rs7597098; rs5831970; rs10180609; rs11422876; rs7589970; rs34846508; rs9808097; rs35846165; rs10560036; rs34865102; rs34139905; rs34723803; rs7599338; rs34152035; rs13016371; rs35042449; rs35969126; rs13410401; rs34496195; rs34090357; rs11689204; rs13389936; rs35577873; rs13424862; rs4402813; rs10602884; rs13003042; rs13026217; rs34686385; rs13026795; rs7595415; rs6724399; rs11439496; rs6546507; rs35454289; rs11420444; rs11296709; rs13026027; rs34170709; rs35630408; rs13026609; rs13385161; rs35356748; rs13393162; rs7340310; rs35112325; rs34121282; rs12474957; rs12997521; rs13002847; rs10689762; rs11360015; rs11489048; rs35106317; rs11464823; rs28678591; rs11458758; rs34325453; rs13431730; rs6759162; rs10700322; rs13019789; rs10175215; rs11363421; rs34091929; rs35658587; rs13392380; rs10714224; rs35392088; rs13408397; rs5831971; rs35105753; rs13430064; rs6721745; rs35636082; rs10203225; rs13026233; rs35631369; rs13026810; rs10203394; rs34754512; rs34527712; rs34022172; rs35777075; rs13411452; rs11889454; rs4302256; rs10715095; rs10674804; rs35619705; rs10196679; rs11883798; rs10172902; rs11407687; rs34806849; rs35361967; rs34509988; rs13388542; rs34477438; rs4402814; rs35366403; rs13385290; rs17552724; rs10185336; rs3182038; rs13385291; rs7568674; rs36057221; rs34799398; rs10170036; rs12615384; rs13751; rs35380455; rs4493312; rs4535086; rs5017686; rs7559627; rs7586596

# Metabolic_Enzyme_24_General_References:
1460020; 11679416

# Metabolic_Enzyme_24_References:
16220784; 16339923

# Metabolic_Enzyme_25_ID:
7763

# Metabolic_Enzyme_25_Name:
6-phosphofructokinase type C

# Metabolic_Enzyme_25_Synonyms:
Phosphofructokinase 1; Phosphohexokinase; Phosphofructo-1-kinase isozyme C; PFK-C; 6- phosphofructokinase, platelet type

# Metabolic_Enzyme_25_Gene_Name:
PFKP

# Metabolic_Enzyme_25_Protein_Sequence:
>6phosphofructokinase type 
CMDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYF
IYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGI
TNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFC
GTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFL
PESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYD
TRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLME
CVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVG
APAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGT
KRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATV
SNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAG
ADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGK
GVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICV
LGISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHV
QPWSV

# Metabolic_Enzyme_25_Number_of_Residues:
784

# Metabolic_Enzyme_25_Molecular_Weight:
85597

# Metabolic_Enzyme_25_Theoretical_pI:
7.60

# Metabolic_Enzyme_25_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  phosphofructokinase activity
Function:  6-phosphofructokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  protein complex
Component:  6-phosphofructokinase complex
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_25_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_25_Specific_Function:
ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

# Metabolic_Enzyme_25_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00030  Pentose phosphate pathway;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism

# Metabolic_Enzyme_25_Reaction:
ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate

# Metabolic_Enzyme_25_Pfam_Domain_Function:
PF00365:PFK

# Metabolic_Enzyme_25_Signals:
None

# Metabolic_Enzyme_25_Transmembrane_Regions:
None

# Metabolic_Enzyme_25_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_25_EC_Link:
EC 2.7.1.11

# Metabolic_Enzyme_25_GenBank_ID_Protein:
560105

# Metabolic_Enzyme_25_SwissProt_ID:
K6PP_HUMAN (Q01813)

# Metabolic_Enzyme_25_swissprot_Name:
Not Available

# Metabolic_Enzyme_25_Genecard_id:
PFKP

# Metabolic_Enzyme_25_Geneatlas_id:
PFKP

# Metabolic_Enzyme_25_hgnc_id:
HGNC:8878

# Metabolic_Enzyme_25_PDB_ID:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_25_Subcellular_Location:
Not Available

# Metabolic_Enzyme_25_Gene_Sequence:
>2355 bp
ATGGACGCGGACGACTCCCGGGCCCCCAAGGGCTCCTTGCGGAAGTTCCTGGAGCACCTC
TCCGGGGCCGGCAAGGCCATCGGCGTGCTGACCAGCGGCGGGGATGCTCAAGGTATGAAC
GCTGCCGTCCGTGCCGTGGTGCGCATGGGTATCTACGTGGGGGCCAAGGTGTACTTCATC
TACGAGGGCTACCAGGGCATGGTGGACGGAGGCTCAAACATCGCAGAGGCCGACTGGGAG
AGTGTCTCCAGCATCCTGCAAGTGGGCGGGACGATCATTGGCAGTGCGCGGTGCCAGGCC
TTCCGCACGCGGGAAGGCCGCCTGAAGGCTGCTTGCAACCTGCTGCAGCGCGGCATCACC
AACCTGTGTGTGATCGGCGGGGACGGGAGCCTCACCGGGGCCAACCTCTTCCGGAAGGAG
TGGAGTGGGCTGCTGGAGGAGCTGGCCAGGAACGGCCAGATCGATAAGGAGGCCGTGCAG
AAGTACGCCTACCTCAACGTGGTGGGCATGGTGGGCTCCATCGACAATGATTTCTGCGGC
ACCGACATGACCATCGGCACGGACTCCGCCCTGCACAGGATCATCGAGGTCGTCGACGCC
ATCATGACCACGGCCCAGAGCCACCAGAGGACCTTCGTTCTGGAGGTGATGGGACGACAC
TGTGGGTACCTGGCCCTGGTGAGTGCCTTGGCCTGCGGTGCGGACTGGGTGTTCCTTCCA
GAATCTCCACCAGAGGAAGGCTGGGAGGAGCAGATGTGTGTCAAACTCTCGGAGAACCGT
GCCCGGAAAAAAAGGCTGAATATTATTATTGTGGCTGAAGGAGCAATTGATACCCAAAAT
AAACCCATCACCTCTGAGAAAATCAAAGAGCTTGTCGTCACGCAGCTGGGCTATGACACA
CGTGTGACCATCCTCGGGCACGTGCAGAGAGGAGGGACCCCTTCGGCATTCGACAGGATC
TTGGCCAGCCGCATGGGAGTGGAGGCAGTCATCGCCTTGCTAGAGGCCACCCCGGACACC
CCAGCTTGCGTCGTGTCACTGAACGGGAACCACGCCGTGCGCCTGCCGCTGATGGAGTGC
GTGCAGATGACTCAGGATGTGCAGAAGGCGATGGACGAGAGGAGATTTCAAGATGCGGTT
CGACTCCGAGGGAGGAGCTTTGCGGGCAACCTGAACACCTACAAGCGACTTGCCATCAAG
CTGCCGGATGATCAGATCCCAAAGACCAATTGCAACGTAGCTGTCATCAACGTGGGGGCA
CCCGCGGCTGGGATGAACGCGGCCGTACGCTCAGCTGTGCGCGTGGGCATTGCCGACGGC
CACAGGATGCTCGCCATCTATGATGGCTTTGACGGCTTCGCCAAGGGCCAGATCAAAGAA
ATCGGCTGGACAGATGTCGGGGGCTGGACCGGCCAAGGAGGCTCCATTCTTGGGACAAAA
CGCGTTCTCCCGGGGAAGTACTTGGAAGAGATCGCCACACAGATGCGCACGCACAGCATC
AACGCGCTGCTGATCATCGGTGGATTCGAGGCCTACCTGGGACTCCTGGAGCTGTCAGCC
GCCCGGGAGAAGCACGAGGAGTTCTGTGTCCCCATGGTCATGGTTCCCGCTACTGTGTCC
AACAATGTGCCGGGTTCCGATTTCAGCATCGGGGCAGACACCGCCCTGAACACTATCACC
GACACCTGCGACCGCATCAAGCAGTCCGCCAGCGGAACCAAGCGGCGCGTGTTCATCATC
GAGACCATGGGCGGCTACTGTGGCTACCTGGCCAACATGGGGGGGCTCGCGGCCGGAGCT
GATGCCGCATACATTTTCGAAGAGCCCTTCGACATCAGGGATCTGCAGTCCAACGTGGAG
CACCTGACGGAGAAAATGAAGACCACCATCCAGAGAGGCCTTGTGCTCAGAAATGAGAGC
TGCAGTGAAAACTACACCACCGACTTCATTTACCAGCTGTATTCAGAAGAGGGCAAAGGC
GTGTTTGACTGCAGGAAGAACGTGCTGGGTCACATGCAGCAGGGTGGGGCACCCTCTCCA
TTTGATAGAAACTTTGGAACCAAAATCTCTGCCAGAGCTATGGAGTGGATCACTGCAAAA
CTCAAGGAGGCCCGGGGCAGAGGAAAAAAATTTACCACCGATGATTCCATTTGTGTGCTG
GGAATAAGCAAAAGAAACGTTATTTTTCAACCTGTGGCAGAGCTGAAGAAGCAAACGGAT
TTTGAGCACAGGATTCCCAAAGAACAGTGGTGGCTCAAGCTACGGCCCCTCATGAAAATC
CTGGCCAAGTACAAGGCCAGCTATGACGTGTCGGACTCAGGCCAGCTGGAACATGTGCAG
CCCTGGAGTGTCTGA

# Metabolic_Enzyme_25_GenBank_ID_Gene:
D25328

# Metabolic_Enzyme_25_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_25_Locus:
10p15.3-p15.2

# Metabolic_Enzyme_25_SNPs:
rs2306302; rs1132173; rs4881086; rs12572717; rs1052333; rs1052309; rs11251721; rs11542779; rs11542777; rs11542780; rs1052337; rs35828349; rs4881080; rs3816699; rs9063; rs1052929; rs1053000; rs542; rs543; rs541; rs7673; rs3816712; rs2388564; rs867274; rs2388595; rs2306294; rs2306297; rs7901550; rs2306310; rs7913237; rs2279211; rs10508245; rs2388510; rs6602029; rs2892550; rs3814587; rs4881099; rs7080240; rs6602028; rs2306312; rs3829915; rs2306304; rs7896691; rs7086721; rs7923989; rs7916889; rs6602030; rs2279215; rs6602027; rs4881091; rs2306311; rs2279212; rs7922072; rs4391741; rs2388594; rs10795000; rs4611105; rs3814590; rs730141; rs9423693; rs7100185; rs4881101; rs4390256; rs2306305; rs4881084; rs2279208; rs882849; rs7913473; rs7902549; rs7096334; rs4545444; rs7082863; rs2306299; rs7924111; rs4381274; rs4880592; rs10903969; rs9630129; rs7075489; rs7096442; rs12268267; rs11819604; rs11251702; rs7076989; rs2306293; rs12569790; rs11817505; rs12570754; rs7082524; rs17284739; rs9423690; rs2388565; rs4881105; rs4881098; rs10508246; rs7918368; rs11251694; rs10903970; rs4881074; rs10903959; rs4881085; rs4517415; rs2388566; rs7342021; rs2306309; rs7894036; rs10794999; rs4881075; rs12569846; rs7091322; rs10903967; rs9423462; rs10903972; rs11251727; rs2388569; rs7901589; rs11591441; rs3829914; rs4598574; rs3816698; rs4881093; rs9423474; rs11251724; rs3740613; rs2306307; rs2306314; rs9423467; rs7896260; rs10903974; rs2892554; rs4595438; rs4881079; rs2388567; rs17131897; rs3816701; rs9423466; rs11592061; rs11251697; rs7086902; rs11251741; rs2306316; rs3814588; rs12257705; rs10903962; rs7080058; rs11599851; rs7910054; rs17212803; rs872398; rs17132175; rs2306306; rs9423487; rs2306315; rs6602032; rs10903955; rs10903961; rs3814589; rs4306207; rs11818475; rs4881077; rs9423680; rs4881087; rs9423489; rs2279210; rs7075876; rs9423490; rs6602031; rs11251723; rs12762657; rs11812979; rs11251711; rs10903954; rs12776036; rs4881097; rs7083162; rs2279206; rs4269839; rs7094776; rs7903250; rs9423491; rs10751913; rs12253549; rs7915793; rs7906901; rs2388570; rs3842695; rs9804219; rs3829917; rs11251719; rs12572060; rs4881082; rs4256893; rs9423471; rs10903960; rs17132578; rs2279207; rs7091146; rs7896897; rs7071398; rs12415723; rs9423464; rs7918168; rs11251729; rs4880590; rs7902539; rs4999370; rs9804221; rs2388552; rs7907949; rs9423681; rs11251732; rs11251707; rs4881081; rs7900748; rs10795002; rs11815740; rs17285851; rs4881078; rs3829916; rs7896829; rs7074733; rs11251709; rs9423685; rs12247270; rs11598339; rs10903968; rs7898894; rs3740611; rs7900171; rs17135865; rs2279204; rs4271292; rs12412712; rs9423469; rs10430751; rs9423472; rs11251696; rs7915264; rs12769974; rs9423692; rs11592619; rs4881095; rs7913254; rs7094648; rs11251742; rs11251695; rs9423691; rs2306301; rs2279209; rs7090199; rs9423698; rs7909171; rs3816703; rs4469783; rs10751914; rs10903966; rs3740610; rs11818602; rs9423473; rs2279205; rs1107048; rs11251734; rs11251728; rs2388571; rs9423485; rs7076698; rs11251710; rs11591990; rs6602023; rs9423494; rs4391742; rs8181285; rs2388573; rs4424569; rs10795004; rs9423695; rs3829912; rs11595224; rs11251715; rs7088110; rs10903957; rs10903973; rs7916196; rs7893663; rs10795005; rs11251720; rs4881094; rs9423476; rs4881089; rs10903963; rs3829911; rs2388574; rs4881100; rs9423475; rs9423686; rs2279213; rs10903958; rs6602026; rs3842696; rs7901291; rs9423477; rs3740612; rs7896500; rs2279203; rs10751912; rs2388568; rs4281389; rs6602022; rs7079667; rs872399; rs11251730; rs9804296; rs9423697; rs4881090; rs9423492; rs2388551; rs11251693; rs11595461; rs3814591; rs4881088; rs11595530; rs9423689; rs12357621; rs11591423; rs12414599; rs7914782; rs12245370; rs12258216; rs7074889; rs10458792; rs10430770; rs2388592; rs12358995; rs3816700; rs10903953; rs10795003; rs7100037; rs11251733; rs12772110; rs4881083; rs6602024; rs4881092; rs9423470; rs9423479; rs3830218; rs10508244; rs2388550; rs7902685; rs7342119; rs4589191; rs2306308; rs2388563; rs4881106; rs12772817; rs7079217; rs2388562; rs41288721; rs11542782; rs11542778; rs34180069; rs17852638; rs41288715; rs11542781; rs3816704; rs3841604; rs11251743; rs34020709; rs9423465; rs11419779; rs12249060; rs9423481; rs11251716; rs12246252; rs35454947; rs10552241; rs10528387; rs12571307; rs2306318; rs7903389; rs4991347; rs35621470; rs2306303; rs34612453; rs11251703; rs36062383; rs41288731; rs41285619; rs41288717; rs35044971; rs36124101; rs34773391; rs7914040; rs10611976; rs36123078; rs10458791; rs35763309; rs7342088; rs35304719; rs7893811; rs34970131; rs10673964; rs9423483; rs7087044; rs11312438; rs9423682; rs35870724; rs41288727; rs7911657; rs9423480; rs11251712; rs35129023; rs11473992; rs35998692; rs34554786; rs7078002; rs10606109; rs10458790; rs12243817; rs35551233; rs10578594; rs41288713; rs4991348; rs34810963; rs6143743; rs2388572; rs10552310; rs11251726; rs9423482; rs7083310; rs11599643; rs11593072; rs33926028; rs9423463; rs6602025; rs12571292; rs4002022; rs35375917; rs34822234; rs34387880; rs41288719; rs11418900; rs34547664; rs34978134; rs5782687; rs10736966; rs5782680; rs10795006; rs10795001; rs7921605; rs11251717; rs34543032; rs11251705; rs4575170; rs2306317; rs4881096; rs11364694; rs41288729; rs9423684; rs35591312; rs5782685; rs3841457; rs11251708; rs34980049; rs34937212; rs10606110; rs7911305; rs3892593; rs7917172; rs34361470; rs7903088; rs4881076; rs11251704; rs9423461; rs35755098; rs34626444; rs35455312; rs7342001; rs2388591; rs36089632; rs9630123; rs5782686; rs4584487; rs10903964; rs9423688; rs41288711; rs34625271; rs34795068; rs35308134; rs34196028; rs33989675; rs12267216; rs11251698; rs35246156; rs3830217; rs11426937; rs10903965; rs5782683; rs35671672; rs10082547; rs9423484; rs12411383; rs2306300; rs11251740; rs9423460; rs35879516; rs2306296; rs9423687; rs34920157; rs11251737; rs7072300; rs34441916; rs7905464; rs12775265; rs11251736; rs34485324; rs12249143; rs35163491; rs3829913; rs35686601; rs11251731; rs9423694; rs35648106; rs3042667; rs11394580; rs28673062; rs12767011; rs12355909; rs7912275; rs11251725; rs5782684; rs12762623; rs34538474; rs7921718; rs28433695; rs35568047; rs12777199; rs35863365; rs12772744; rs34260521; rs6143744; rs12769056; rs2388575; rs12773602; rs7913100; rs11251739; rs2892549; rs35072017; rs11251701; rs11251714; rs4880589; rs34688896; rs35741420; rs11251706; rs35276282; rs11375841; rs11251722; rs2306298; rs12411396; rs12769988; rs35751635; rs34430271; rs12250915; rs35571366; rs35303123; rs41288723; rs2388576; rs7071824; rs4880591; rs34453449; rs41288733; rs5782681; rs9423478; rs11251699; rs7072286; rs6143745; rs34390372; rs9702390; rs12355948; rs34128386; rs34273901; rs7896922; rs7919798; rs7474978; rs35768855; rs12412657; rs11251700; rs11251738; rs7898754; rs7082466; rs7071339; rs10582528; rs34600605; rs7088709; rs35381145; rs7093888; rs5782682; rs11251718; rs10903956; rs2306313; rs12571066; rs35890906; rs9423486; rs6143747; rs6143746; rs10175; rs1043146; rs1043158; rs1043166; rs10508247; rs10736965; rs10751909; rs10794997; rs10794998; rs10795007; rs11251688; rs11251744; rs12678; rs12762013; rs12774814; rs12779561; rs12780595; rs17135477; rs17136264; rs17212411; rs17849904; rs1802344; rs1804254; rs2279216; rs2279217; rs2279218; rs2279219; rs2279220; rs2279221; rs2306319; rs2388558; rs2388559; rs2388560; rs2388561; rs34837384; rs34882494; rs35301243; rs35363509; rs35779348; rs3752802; rs3752803; rs3758630; rs3758631; rs3814586; rs4451611; rs4880594; rs4880595; rs4881107; rs4881109; rs4881110; rs6901; rs7081092; rs7094698; rs7097793; rs7898290; rs7898695; rs7904857; rs7908746; rs7911918; rs7924163; rs9129; rs9423495; rs9423701; rs9423702; rs9423703

# Metabolic_Enzyme_25_General_References:
8117307; 1834056

# Metabolic_Enzyme_25_References:
1833241; 6325420

# Metabolic_Enzyme_26_ID:
8050

# Metabolic_Enzyme_26_Name:
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

# Metabolic_Enzyme_26_Synonyms:
6PF-2-K/Fru- 2,6-P2ASE brain/placenta-type isozyme; iPFK-2; Renal carcinoma antigen NY-REN-56[Includes: 6-phosphofructo-2-kinase

# Metabolic_Enzyme_26_Gene_Name:
PFKFB3

# Metabolic_Enzyme_26_Protein_Sequence:
>6phosphofructo2kinase/fructose2,6biphosphatase 3
MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLN
WIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQ
IAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNS
AEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLM
NIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQ
LKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTG
ESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKL
TPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFE
EHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKH

# Metabolic_Enzyme_26_Number_of_Residues:
520

# Metabolic_Enzyme_26_Molecular_Weight:
59610

# Metabolic_Enzyme_26_Theoretical_pI:
8.29

# Metabolic_Enzyme_26_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  fructose metabolism
Process:  fructose 2,6-bisphosphate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_26_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_26_Specific_Function:
Synthesis and degradation of fructose 2,6-bisphosphate

# Metabolic_Enzyme_26_Pathway:
map00051  Fructose and mannose metabolism

# Metabolic_Enzyme_26_Reaction:
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate

# Metabolic_Enzyme_26_Pfam_Domain_Function:
PF01591:6PF2K;
PF00300:PGAM

# Metabolic_Enzyme_26_Signals:
None

# Metabolic_Enzyme_26_Transmembrane_Regions:
None

# Metabolic_Enzyme_26_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_26_EC_Link:
EC 2.7.1.105;EC 3.1.3.46

# Metabolic_Enzyme_26_GenBank_ID_Protein:
1468916

# Metabolic_Enzyme_26_SwissProt_ID:
F263_HUMAN (Q16875)

# Metabolic_Enzyme_26_swissprot_Name:
Not Available

# Metabolic_Enzyme_26_Genecard_id:
PFKFB3

# Metabolic_Enzyme_26_Geneatlas_id:
PFKFB3

# Metabolic_Enzyme_26_hgnc_id:
HGNC:8874

# Metabolic_Enzyme_26_PDB_ID:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_26_Subcellular_Location:
Not Available

# Metabolic_Enzyme_26_Gene_Sequence:
>1563 bp
ATGCCGTTGGAACTGACGCAGAGCCGAGTGCAGAAGATCTGGGTGCCCGTGGACCACAGG
CCCTCGTTGCCCAGATCCTGTGGGCCAAAGCTGACCAACTCCCCCACCGTCATCGTCATG
GTGGGCCTCCCCGCCCGGGGCAAGACCTACATCTCCAAGAAGCTGACTCGCTACCTCAAC
TGGATTGGCGTCCCCACAAAAGTGTTCAACGTCGGGGAGTATCGCCGGGAGGCTGTGAAG
CAGTACAGCTCCTACAACTTCTTCCGCCCCGACAATGAGGAAGCCATGAAAGTCCGGAAG
CAATGTGCCTTAGCTGCCTTGAGAGATGTCAAAAGCTACCTGGCGAAAGAAGGGGGACAA
ATTGCGGTTTTCGATGCCACCAATACTACTAGAGAGAGGAGACACATGATCCTTCATTTT
GCCAAAGAAAATGACTTTAAAGCGTTTTTCATCGAGTCGGTGTGCGACGACCCTACAGTT
GTGGCCTCCAATATCATGGAAGTTAAAATCTCCAGCCCGGATTACAAAGACTGCAACTCG
GCAGAAGCCATGGACGACTTCATGAAGAGGATCAGTTGCTATGAAGCCAGCTACCAGCCC
CTCGACCCCGACAAATGCGACAGGGACTTGTCGCTGATCAAGGTGATTGACGTGGGCCGG
AGGTTCCTGGTGAACCGGGTGCAGGACCACATCCAGAGCCGCATCGTGTACTACCTGATG
AACATCCACGTGCAGCCGCGTACCATCTACCTGTGCCGGCACGGCGAGAACGAGCACAAC
CTCCAGGGCCGCATCGGGGGCGACTCAGGCCTGTCCAGCCGGGGCAAGAAGTTTGCCAGT
GCTCTGAGCAAGTTCGTGGAGGAGCAGAACCTGAAGGACCTGCGCGTGTGGACCAGCCAG
CTGAAGAGCACCATCCAGACGGCCGAGGCGCTGCGGCTGCCCTACGAGCAGTGGAAGGCG
CTCAATGAGATCGACGCGGGCGTCTGTGAGGAGCTGACCTACGAGGAGATCAGGGACACC
TACCCTGAGGAGTATGCGCTGCGGGAGCAGGACAAGTACTATTACCGCTACCCCACCGGG
GAGTCCTACCAGGACCTGGTCCAGCGCTTGGAGCCAGTGATCATGGAGCTGGAGCGGCAG
GAGAATGTGCTGGTCATCTGCCACCAGGCCGTCCTGCGCTGCCTGCTTGCCTACTTCCTG
GATAAGAGTGCAGAGGAGATGCCCTACCTGAAATGCCCTCTTCACACCGTCCTGAAACTG
ACGCCTGTCGCTTATGGCTGCCGTGTGGAATCCATCTACCTGAACGTGGAGTCCGTCTGC
ACACACCGGGAGAGGTCAGAGGATGCAAAGAAGGGACCTAACCCGCTCATGAGACGCAAT
AGTGTCACCCCGCTAGCCAGCCCCGAACCCACCAAAAAGCCTCGCATCAACAGCTTTGAG
GAGCATGTGGCCTCCACCTCGGCCGCCCTGCCCAGCTGCCTGCCCCCGGAGGTGCCCACG
CAGCTGCCTGGACAAAACATGAAAGGCTCCCGGAGCAGCGCTGACTCCTCCAGGAAACAC
TGA

# Metabolic_Enzyme_26_GenBank_ID_Gene:
D49817

# Metabolic_Enzyme_26_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_26_Locus:
10p14-p15

# Metabolic_Enzyme_26_SNPs:
rs2230271; rs34714325; rs35877496; rs2230272; rs1539234; rs3750667; rs3829148; rs1064891; rs1539232; rs1539233; rs11596368; rs3750665; rs1064890; rs617245; rs2516614; rs756567; rs2794982; rs2794981; rs12357847; rs12255582; rs7071157; rs1557112; rs3793721; rs1557111; rs7904792; rs2516626; rs2073629; rs10737057; rs2765827; rs2298102; rs11813270; rs12412134; rs2516615; rs2104495; rs633733; rs9664762; rs943117; rs2516619; rs6602514; rs2148293; rs4750081; rs2148294; rs2516623; rs2516617; rs4747952; rs2516624; rs2182411; rs2148292; rs7915821; rs11257349; rs2765826; rs7915298; rs11817400; rs7896450; rs3838746; rs6602554; rs7898529; rs2148289; rs11595843; rs633835; rs11257456; rs11812743; rs11818646; rs2073628; rs2516616; rs2516622; rs11814534; rs2765824; rs7904794; rs7915327; rs17152229; rs11818596; rs10906032; rs947478; rs4750075; rs2182412; rs7924061; rs10466308; rs4747921; rs2148291; rs2251469; rs3793715; rs11593269; rs2794983; rs10466309; rs2516618; rs10906037; rs3838747; rs17152226; rs10906000; rs11812483; rs3793720; rs12571428; rs3829147; rs17152173; rs11257289; rs2148290; rs10906022; rs2516627; rs603973; rs11257470; rs11257472; rs3814192; rs672376; rs10795916; rs17136780; rs11815715; rs10795915; rs36005730; rs12569742; rs35413228; rs35117690; rs34832528; rs35050271; rs34184265; rs34969226; rs41291287; rs11257460; rs1064889; rs1064894; rs2387004; rs1064896; rs11541590; rs1064899; rs34059583; rs1064897; rs36102318; rs1064893; rs1064900; rs4002912; rs1064898; rs1064888; rs41291285; rs1064895; rs1064887; rs11541589; rs3814190; rs2387005; rs1064892; rs35781052; rs2516620; rs36134041; rs35364998; rs11257356; rs12357293; rs3083330; rs28532995; rs11816551; rs5782882; rs3083328; rs34773918; rs34860344; rs34889684; rs12764718; rs36107490; rs7902148; rs8181466; rs11593270; rs34514753; rs3216038; rs2516621; rs28699422; rs12267359; rs4750082; rs34128804; rs11257430; rs7907736; rs35009657; rs7082527; rs35995560; rs4747924; rs41306804; rs11257259; rs11816537; rs34794656; rs11257249; rs41291259; rs3084011; rs9424133; rs11257302; rs12572271; rs28391561; rs35881449; rs12769043; rs34000061; rs12359050; rs35987650; rs7898543; rs11257270; rs35890201; rs12780600; rs12783826; rs12779445; rs34821327; rs4237418; rs3793718; rs7903828; rs12249726; rs11257374; rs11257299; rs4747951; rs35193180; rs11816550; rs35512321; rs2025720; rs35531305; rs12779252; rs12358052; rs5782885; rs7894711; rs11257278; rs28605361; rs35426728; rs11257345; rs7921279; rs12360217; rs12259164; rs41291281; rs34235557; rs36147125; rs12359693; rs12572481; rs4237417; rs9424132; rs11257279; rs34276031; rs3829146; rs2516625; rs3084014; rs11257453; rs3833726; rs35617103; rs7895111; rs12770641; rs3084010; rs12775327; rs36070651; rs34569958; rs35618553; rs34836891; rs34819394; rs5782883; rs12259988; rs12571429; rs2242617; rs35532228; rs7895124; rs7894984; rs10906023; rs11591587; rs41310217; rs12764725; rs619797; rs35929982; rs34741388; rs28515908; rs34239981; rs34943779; rs35447462; rs34239137; rs35710132; rs35609333; rs5782881; rs7921003; rs12785005; rs7895104; rs5782884; rs12784609; rs12218519; rs12241169; rs12780995; rs41291275; rs1079445; rs11257234; rs11257229; rs1079446; rs11257235; rs34616071; rs35413444; rs17136787; rs10795869; rs10905976; rs11257188; rs11257192; rs11257200; rs11257206; rs11257482; rs11592813; rs11596852; rs11815773; rs12219292; rs12219678; rs12246508; rs12256901; rs12415582; rs12572467; rs12573050; rs17152391; rs17152396; rs17152400; rs17361911; rs4750160; rs4750166; rs637041; rs637452; rs681699; rs7076428; rs7085250; rs7092365; rs7894118; rs7894544; rs7916509; rs7916923; rs9733630

# Metabolic_Enzyme_26_General_References:
8830046; 10072580; 10077634; 10508479

# Metabolic_Enzyme_26_References:
1833982; 2969698; 7619077

# Metabolic_Enzyme_27_ID:
8582

# Metabolic_Enzyme_27_Name:
TKTL2 protein

# Metabolic_Enzyme_27_Synonyms:
Not Available

# Metabolic_Enzyme_27_Gene_Name:
TKTL2

# Metabolic_Enzyme_27_Protein_Sequence:
>TKTL2 protein
AEGRRGRGGHVRALPRWVVGVLRRRLLCQTDKREMMANDAKPDVKTVQVLRDTANRLRIH
SIRATCASGSGQLTSCCSAAEVVSVLFFHTMKYKQTDPEHPDNDRFILSRGHAAPILYAA
WVEVGDISESDLLNLRKLHSDLERHPTPRLPFVDVATGSLGQGLGTACGMAYTGKYLDKA
SYRVFCLMGDGESSEGSVWEAFAFASHYNLDNLVAVFDVNRLGQSGPAPLEHGADIYQNC
CEAFGWNTYLVDGHDVEALCQAFWQASQVKNKPTAIVAKTFKGRGIPNIEDAENWHGKPV
PKERADAIVKLIESQIQTNENLIPKSPVEDSPQISVTDIKMTSPHAYKVGDKIATQKTYG
LALAKLGRANERVIVLSGDTMNSTFSEIFRKEHPERFIECIIAEQNMVSVALGCATRGRT
IAFAGAFAAFFTRAFDQLRMGAISQANINLIGSHCGVSTGEDGVSQMALEDLAMFRSIPN
CTVFYPSDAISTEHAIYLAANTKGMCFIRTSQPETAVIYTPQENFEIGQAKVVRHGVNDK
VTVIGAGVTLHEALEAADHLSQQGISVRVIDPFTIKPLDAATIISSAKATGGRVITVEDH
YREGGIGEAVCAAVSREPDILVHQLAVSGVPQRGKTSELLDMFGISTRHIIAAVTLTLMK


# Metabolic_Enzyme_27_Number_of_Residues:
660

# Metabolic_Enzyme_27_Molecular_Weight:
71841

# Metabolic_Enzyme_27_Theoretical_pI:
6.96

# Metabolic_Enzyme_27_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring aldehyde or ketonic groups
Function:  transketolase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_27_General_Function:
Energy production and conversion

# Metabolic_Enzyme_27_Specific_Function:
Not Available

# Metabolic_Enzyme_27_Pathway:
Not Available

# Metabolic_Enzyme_27_Reaction:
Not Available

# Metabolic_Enzyme_27_Pfam_Domain_Function:
PF02779:Transket_pyr
PF02780:Transketolase_C
PF00456:Transketolase_N

# Metabolic_Enzyme_27_Signals:
Not Available

# Metabolic_Enzyme_27_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_27_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_27_EC_Link:
EC 2.2.1.1

# Metabolic_Enzyme_27_GenBank_ID_Protein:
133777215

# Metabolic_Enzyme_27_SwissProt_ID:
Q8NCT0_HUMAN (Q8NCT0)

# Metabolic_Enzyme_27_swissprot_Name:
Not Available

# Metabolic_Enzyme_27_Genecard_id:
TKTL2

# Metabolic_Enzyme_27_Geneatlas_id:
TKTL2

# Metabolic_Enzyme_27_hgnc_id:
HGNC:25313

# Metabolic_Enzyme_27_PDB_ID:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_27_Subcellular_Location:
Not Available

# Metabolic_Enzyme_27_Gene_Sequence:
>1881 bp
ATGATGGCCAACGACGCCAAGCCCGACGTGAAGACCGTGCAGGTGCTGCGGGACACAGCC
AACCGCCTGCGGATCCATTCCATCAGGGCCACGTGTGCCTCTGGTTCTGGCCAGCTCACG
TCGTGCTGCAGTGCAGCGGAGGTCGTGTCTGTCCTCTTCTTCCACACGATGAAGTATAAA
CAGACAGACCCAGAACACCCGGACAACGACCGGTTCATCCTCTCCAGGGGACATGCTGCT
CCTATCCTCTATGCTGCTTGGGTGGAGGTGGGTGACATCAGTGAATCTGACTTGCTGAAC
CTGAGGAAACTTCACAGCGACTTGGAGAGACACCCTACCCCCCGATTGCCGTTTGTTGAC
GTGGCAACAGGGTCCCTAGGTCAGGGATTAGGTACTGCATGTGGAATGGCTTATACTGGC
AAGTACCTTGACAAGGCCAGCTACCGGGTGTTCTGCCTTATGGGAGATGGCGAATCCTCA
GAAGGCTCTGTGTGGGAGGCTTTTGCTTTTGCCTCCCACTACAACTTGGACAATCTCGTG
GCGGTCTTCGACGTGAACCGCTTGGGACAAAGTGGCCCTGCACCCCTTGAGCATGGCGCA
GACATCTACCAGAATTGCTGTGAAGCCTTTGGATGGAATACTTACTTAGTGGATGGCCAT
GATGTGGAGGCCTTGTGCCAAGCATTTTGGCAAGCAAGTCAAGTGAAGAACAAGCCTACT
GCTATAGTTGCCAAGACCTTCAAAGGTCGGGGTATTCCAAATATTGAGGATGCAGAAAAT
TGGCATGGAAAGCCAGTGCCAAAAGAAAGAGCAGATGCAATTGTCAAATTAATTGAGAGT
CAGATACAGACCAATGAGAATCTCATACCAAAATCGCCTGTGGAAGACTCACCTCAAATA
AGCGTCACAGATATAAAAATGACCTCCCCACATGCTTACAAAGTTGGTGACAAGATAGCT
ACTCAGAAAACATATGGTTTGGCTCTGGCTAAACTGGGCCGTGCAAATGAAAGAGTTATT
GTTCTGAGTGGTGACACGATGAACTCCACCTTTTCTGAGATATTCAGGAAAGAACACCCT
GAGCGTTTCATAGAGTGTATTATTGCTGAACAAAACATGGTAAGTGTGGCACTAGGCTGT
GCTACACGTGGTCGAACCATTGCTTTTGCTGGTGCTTTTGCTGCCTTTTTTACTAGAGCA
TTCGATCAGCTCCGAATGGGAGCCATTTCTCAAGCCAATATCAACCTTATTGGTTCCCAC
TGTGGGGTATCCACTGGAGAAGATGGAGTCTCCCAGATGGCCCTGGAGGATCTAGCCATG
TTCCGAAGCATTCCCAATTGTACTGTTTTCTATCCAAGTGATGCCATCTCGACAGAGCAT
GCTATTTATCTAGCCGCCAATACCAAGGGAATGTGCTTCATTCGAACCAGCCAACCAGAA
ACTGCAGTTATTTATACCCCACAAGAAAATTTTGAGATTGGCCAGGCCAAGGTGGTCCGC
CACGGTGTCAATGATAAAGTCACAGTAATTGGAGCTGGAGTTACTCTCCATGAAGCCTTA
GAAGCTGCTGACCATCTTTCTCAACAAGGTATTTCTGTCCGTGTCATCGACCCATTTACC
ATTAAACCCCTGGATGCCGCCACCATCATCTCCAGTGCAAAAGCCACAGGCGGCCGAGTT
ATCACAGTGGAGGATCACTACAGGGAAGGTGGCATTGGAGAAGCTGTTTGTGCAGCTGTC
TCCAGGGAGCCTGATATCCTTGTTCATCAACTGGCAGTGTCAGGAGTGCCTCAACGTGGG
AAAACTAGTGAATTGCTGGATATGTTTGGAATCAGTACCAGACACATTATAGCAGCCGTA
ACACTTACTTTAATGAAGTAA

# Metabolic_Enzyme_27_GenBank_ID_Gene:
BC028707

# Metabolic_Enzyme_27_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_27_Locus:
4q32.3

# Metabolic_Enzyme_27_SNPs:
rs11735477; rs3811750; rs17043707; rs34405980; rs34864894; rs9308059; rs9308060; rs11944657; rs17576133; rs10004056; rs28742006; rs17852601; rs17856818; rs34977388; rs13132357; rs28652675; rs35698908; rs36049879; rs9991138; rs35711650; rs10005483; rs10017973; rs12642830; rs12643951; rs13139778; rs13353785; rs2119677; rs3135441; rs3135442; rs3135443; rs3135444; rs3135445; rs35418719; rs35873355; rs36038893; rs4234960; rs4691924; rs6856912; rs7657407

# Metabolic_Enzyme_27_General_References:
12477932

# Metabolic_Enzyme_27_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
6081

# Macromolecular_Interacting_Partner_1_Name:
Fructose-1,6-bisphosphatase isozyme 2

# Macromolecular_Interacting_Partner_1_Synonyms:
D-fructose-1,6- bisphosphate 1-phosphohydrolase 2; FBPase 2

# Macromolecular_Interacting_Partner_1_Gene_Name:
FBP2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Fructose1,6bisphosphatase isozyme 2
MTDRSPFETDMLTLTRYVMEKGRQAKGTGELTQLLNSMLTAIKAISSAVRKAGLAHLYGI
AGSVNVTGDEVKKLDVLSNSLVINMVQSSYSTCVLVSEENKDAIITAKEKRGKYVVCFDP
LDGSSNIDCLASIGTIFAIYRKTSEDEPSEKDALQCGRNIVAAGYALYGSATLVALSTGQ
GVDLFMLDPALGEFVLVEKDVKIKKKGKIYSLNEGYAKYFDAATTEYVQKKKFPEDGSAP
YGARYVGSMVADVHRTLVYGGIFLYPANQKSPKGKLRLLYECNPVAYIIEQAGGLATTGT
QPVLDVKPEAIHQRVPLILGSPEDVQEYLTCVQKNQAGS

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
339

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
36744

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.29

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate

# Macromolecular_Interacting_Partner_1_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00030  Pentose phosphate pathway;
 map00051  Fructose and mannose metabolism;
 map00710  Carbon fixation

# Macromolecular_Interacting_Partner_1_Reaction:
D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00316:FBPase

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 3.1.3.11

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
2154755

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
F16P2_HUMAN (O00757)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
FBP2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
FBP2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:3607

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1020 bp
ATGACGGACAGAAGCCCCTTCGAAACCGACATGCTCACCCTGACCCGCTACGTTATGGAA
AAGGGGCGTCAGGCCAAAGGGACTGGGGAGCTCACCCAGCTGCTGAACTCAATGCTGACG
GCCATCAAAGCCATCTCCTCGGCTGTGCGCAAGGCCGGTCTGGCCCACCTGTATGGAATC
GCAGGAAGCGTTAACGTGACGGGAGATGAGGTGAAGAAACTGGATGTGCTATCCAATTCC
CTGGTGATCAACATGCTCCAATCCTCCTATAGTACCTGCGTCCTGGTCTCAGAAGAGAAT
AAGGACGCCATCATCACCGCCAAGGAGAAGCGGGGGAAATACGTGGTCTGCTTTGACCCA
CTGGATGGATCTTCCAATATTGACTGCCTGGCCTCCATCGGAACCATCTTTGCCATCTAT
AGAAAGACCTCAGAGGATGAGCCTTCTGAAAAGGATGCCCTGCAGTGTGGCCGCAATATT
GTGGCCGCAGGTTATGCGCTGTACGGTAGTGCAACCCTGGTGGCTCTCTCCACAGGGCAA
GGCGTGGACCTCTTCATGCTTGACCCGGCTCTTGGTGAATTTGTCCTGGTGGAAAAAGAT
GTCAAGATTAAGAAGAAAGGAAAGATTTACAGCCTGAATGAGGGCTATGCCAAGTATTTT
GATGCGGCCACCACTGAATATGTGCAGAAAAAGAAATTCCCTGAGGATGGCAGTGCTCCC
TATGGGGCCAGGTATGTGGGCTCCATGGTGGCTGACGTGCACCGCACCCTGGTCTATGGA
GGAATCTTCCTGTACCCAGCCAACCAGAAGAGCCCTAAGGGCAAGCTCCGGCTCCTGTAT
GAATGCAATCCCGTGGCCTACATCATTGAGCAGGCAGGAGGCTTGGCGACCACGGGGACC
CAGCCTGTACTGGACGTGAAGCCCGAGGCAATTCACCAGCGAGTCCCCCTCATTCTGGGG
TCACCAGAGGATGTGCAGGAATATCTCACCTGTGTGCAGAAAAATCAGGCAGGCAGCTAG


# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
Y10812

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_1_Locus:
9q22.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs573212; rs2280301; rs1048510; rs1543185; rs2679602; rs540124; rs598386; rs509022; rs644237; rs802918; rs599229; rs609901; rs540236; rs635108; rs642477; rs965474; rs2987883; rs642952; rs2945796; rs2406665; rs693122; rs7039582; rs600130; rs3852401; rs2987882; rs6479554; rs7035381; rs7870433; rs1754432; rs645125; rs576745; rs612498; rs10115929; rs2406666; rs2945798; rs2280300; rs642035; rs10821367; rs498533; rs4744353; rs4744354; rs10116047; rs10821368; rs612952; rs7868159; rs564430; rs498635; rs2292900; rs2987900; rs501380; rs3864789; rs3864790; rs558753; rs548348; rs532027; rs4744357; rs2772011; rs10739976; rs2406664; rs693399; rs7865241; rs558990; rs10761339; rs1754433; rs688843; rs2280303; rs514222; rs781648; rs10761338; rs11790267; rs597003; rs7865772; rs2280302; rs660911; rs16910256; rs539320; rs632506; rs10761336; rs3824485; rs10115132; rs10993251; rs12684576; rs12684591; rs612115; rs10117289; rs2772012; rs586140; rs12683919; rs7861787; rs10993250; rs618272; rs10993248; rs478604; rs663385; rs10122208; rs7036264; rs11789810; rs12684837; rs4743959; rs12238316; rs2460138; rs10821369; rs558526; rs2679606; rs7851510; rs10114605; rs10117554; rs515339; rs3892541; rs802919; rs781650; rs2679601; rs478563; rs10761342; rs7862669; rs12115356; rs10821370; rs1568305; rs612202; rs2772023; rs10114599; rs612153; rs10761335; rs10993254; rs4314706; rs2993963; rs874248; rs2945802; rs2017136; rs7855117; rs2772013; rs10761344; rs10761334; rs10115489; rs35600708; rs41281156; rs41281154; rs41281152; rs10657369; rs4113133; rs12115836; rs635087; rs528866; rs12684849; rs7866650; rs11792211; rs28621580; rs616451; rs34101061; rs2945795; rs35007372; rs10668765; rs12000648; rs35098649; rs35802953; rs36080313; rs3990918; rs499480; rs34303194; rs2460137; rs11370106; rs4113134; rs35717974; rs13299030; rs2993965; rs10993253; rs13297617; rs33960007; rs12350611; rs11303048; rs639498; rs33934973; rs514561; rs11394532; rs34288791; rs7866757; rs34924732; rs2945797; rs9657694; rs579450; rs2945799; rs33949513; rs10125174; rs9697254; rs34525238; rs2679604; rs35338936; rs36092797; rs34691750; rs1934361; rs7469340; rs34740368; rs7871076; rs10584472; rs12683790; rs4113132; rs34355995; rs602606; rs35662608; rs7037602; rs10120467; rs34748035; rs34886780; rs7856539; rs12344649; rs35999121; rs35548100; rs479197; rs35405769; rs34114809; rs781649; rs12002400; rs35766092; rs34227394; rs35919971; rs34709246; rs13286145; rs12115199; rs34043734; rs7025414; rs36068498; rs4360350; rs2790389; rs7857750; rs10993255; rs878755; rs4744358; rs12004008; rs5899222; rs35892683; rs5899223; rs1042189; rs1062483; rs10761333; rs10761346; rs10993241; rs10993242; rs11795153; rs13295586; rs2274689; rs2679599; rs2679600; rs2772021; rs2772022; rs2987884; rs3780554; rs3802467; rs3802468; rs4743960; rs583365; rs601389; rs7048277; rs9695

# Macromolecular_Interacting_Partner_1_General_References:
9678974

# Macromolecular_Interacting_Partner_1_References:
15769513; 2853625; 6218355; 9361351

# Macromolecular_Interacting_Partner_2_ID:
7193

# Macromolecular_Interacting_Partner_2_Name:
Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide

# Macromolecular_Interacting_Partner_2_Synonyms:
GRPP; Oxyntomodulin; OXY; OXM; Glucagon; Glucagon-like peptide 1; GLP-1; Glucagon-like peptide 1(7-37; GLP-1(7-37; Glucagon-like peptide 1(7-36; GLP-1(7-36; Glucagon-like peptide 2; GLP-2]

# Macromolecular_Interacting_Partner_2_Gene_Name:
GCG

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Glucagon precursor Contains: Glicentin; Glicentinrelated polypeptide
MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTS
DYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFI
AWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMNTILDNLAARDFINWLIQTKITDRK


# Macromolecular_Interacting_Partner_2_Number_of_Residues:
180

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
20909

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.14

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00123:Hormone_2

# Macromolecular_Interacting_Partner_2_Signals:
1-20

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
183270

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
GLUC_HUMAN (P01275)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
GCG

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
GCG

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:4191

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>543 bp
ATGAAAAGCATTTACTTTGTGGCTGGGTTATTTGTAATGCTGGTACAAGGCAGCTGGCAA
CGTTCCCTTCAAGACACAGAGGAGAAATCCAGATCATTCTCAGCTTCCCAGGCAGACCCA
CTCAGTGATCCTGATCAGATGAACGAGGACAAGCGCCATTCACAGGGCACATTCACCAGT
GACTACAGCAAGTATCTGGACTCCAGGCGTGCCCAAGATTTTGTGCAGTGGTTGATGAAT
ACCAAGAGGAACAGGAATAACATTGCCAAACGTCACGATGAATTTGAGAGACATGCTGAA
GGGACCTTTACCAGTGATGTAAGTTCTTATTTGGAAGGCCAAGCTGCCAAGGAATTCATT
GCTTGGCTGGTGAAAGGCCGAGGAAGGCGAGATTTCCCAGAAGAGGTCGCCATTGTTGAA
GAACTTGGCCGCAGACATGCTGATGGTTCTTTCTCTGATGAGATGAACACCATTCTTGAT
AATCTTGCCGCCAGGGACTTTATAAACTGGTTGATTCAGACCAAAATCACTGACAGGAAA
TAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
J04040

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_2_Locus:
2q36-q37

# Macromolecular_Interacting_Partner_2_SNPs:
rs5645; rs4664448; rs6732914; rs4664449; rs10490424; rs10164435; rs11897425; rs7581952; rs7569992; rs7559086; rs5649; rs4664447; rs5653; rs6727317; rs13306377; rs5647; rs5654; rs13306376; rs1990761; rs6717659; rs13001107; rs16846320; rs13416088; rs35424779; rs6717263; rs3811540; rs6717609; rs35328019; rs5650; rs11552334; rs35920035; rs11552338; rs1042405; rs11552330; rs11552335; rs34074912; rs11552339; rs17711059; rs11552332; rs16846334; rs11552331; rs11552336; rs35185096; rs35902561; rs35301560; rs10557377; rs10603613; rs5648; rs34801095; rs10671204; rs33949193; rs5652; rs5646; rs11378120; rs7569999; rs34405490; rs5651; rs11898004; rs35323923; rs13429709; rs10696486; rs34204135; rs35205044; rs3811539; rs7590067; rs11692314; rs17762054; rs41368446; rs34932341; rs10170813; rs10189636; rs11888030; rs13010545; rs13028221; rs2111487; rs2193494; rs2216338; rs2389680; rs2389681; rs3761656; rs4664450; rs6704722; rs6733736; rs7599142

# Macromolecular_Interacting_Partner_2_General_References:
2901414; 3725587; 6877358; 2753890; 8482423; 14557443; 14632334; 9287128; 12651102; 12554744; 12626323; 10605628; 9667960; 11943215; 12627948

# Macromolecular_Interacting_Partner_2_References:
6234302

# Macromolecular_Interacting_Partner_3_ID:
7549

# Macromolecular_Interacting_Partner_3_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
INS

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_3_Signals:
1-24

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
INS

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11p15.5

# Macromolecular_Interacting_Partner_3_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_3_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_3_References:
155405

# Macromolecular_Interacting_Partner_4_ID:
6077

# Macromolecular_Interacting_Partner_4_Name:
Mannose-6-phosphate isomerase

# Macromolecular_Interacting_Partner_4_Synonyms:
Phosphomannose isomerase; PMI; Phosphohexomutase

# Macromolecular_Interacting_Partner_4_Gene_Name:
MPI

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Mannose6phosphate isomerase
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAK
ILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEK
LHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLK
QTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQ
LHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTP
KFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYK
VLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRAC
CLL

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
423

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
46656

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
5.81

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  catalytic activity
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, interconverting aldoses and ketoses
Function:  mannose-6-phosphate isomerase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_4_Specific_Function:
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions

# Macromolecular_Interacting_Partner_4_Pathway:
map00051  Fructose and mannose metabolism

# Macromolecular_Interacting_Partner_4_Reaction:
D-mannose 6-phosphate = D-fructose 6-phosphate

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF01238:PMI_typeI

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
EC 5.3.1.8

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
416017

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
MANA_HUMAN (P34949)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
MPI

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
MPI

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:7216

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cytoplasm (Probable)

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1272 bp
ATGGCCGCTCCGCGAGTATTCCCACTTTCCTGTGCGGTGCAGCAGTATGCCTGGGGGAAG
ATGGGTTCCAACAGCGAAGTGGCGCGGCTGTTGGCCAGCAGTGATCCACTGGCCCAGATC
GCAGAGGACAAGCCTTATGCAGAGTTGTGGATGGGGACTCACCCCCGAGGGGATGCCAAG
ATCCTTGACAACCGCATCTCACAGAAGACCCTAAGCCAGTGGATTGCTGAGAACCAGGAC
AGCTTGGGCTCAAAGGTCAAGGACACCTTTAATGGCAACCTGCCCTTCCTCTTCAAAGTG
CTCTCAGTTGAAACACCCCTGTCCATCCAGGCACACCCTAACAAGGAGCTGGCAGAGAAG
CTGCACCTCCAGGCTCCGCAGCACTACCCCGATGCCAACCACAAGCCAGAGATGGCCATT
GCCCTCACCCCCTTCCAGGGCTTGTGTGGCTTCCGGCCAGTTGAGGAGATTGTAACCTTT
CTAAAGAAGGTGCCTGAGTTTCAGTTCCTGATTGGAGATGAGGCAGCAACACACCTGAAG
CAGACCATGAGCCATGACTCCCAGGCTGTGGCCTCCTCTCTGCAGAGCTGTTTCTCCCAC
CTGATGAAGAGTGAGAAGAAGGTGGTGGTGGAACAGCTCAACCTGTTGGTGAAGCGGATC
TCCCAGCAAGCGGCTGCCGGAAACAACATGGAGGACATCTTTGGGGAGCTTTTGCTACAG
CTGCACCAGCAGTACCCAGGTGATATCGGCTGCTTTGCCATCTACTTCCTGAACCTGCTT
ACCCTGAAGCCTGGGGAGGCCATGTTTCTGGAGGCCAACGTACCCCATGCCTACCTGAAA
GGAGACTGCGTGGAGTGCATGGCGTGTTCAGACAACACAGTTCGTGCTGGCCTGACACCC
AAGTTCATTGATGTGCCAACCCTGTGTGAAATGCTCAGCTATACCCCTAGCTCCAGCAAG
GACAGGCTCTTTCTCCCAACACGGAGTCAGGAAGACCCCTACCTCTCAATCTATGACCCC
CCTGTACCAGACTTCACCATTATGAAGACGGAGGTCCCTGGCTCTGTCACTGAATACAAG
GTCTTGGCACTGGACTCTGCCAGCATCCTCCTGATGGTACAGGGGACAGTAATAGCCAGC
ACACCCACAACCCAGACACCAATCCCTCTGCAACGTGGTGGCGTGCTCTTCATTGGGGCC
AATGAGAGTGTCTCACTGAAGCTTACTGAGCCGAAGGACCTGCTGATATTCCGTGCCTGC
TGTCTGCTGTAA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
X76057

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:15

# Macromolecular_Interacting_Partner_4_Locus:
15q22-qter

# Macromolecular_Interacting_Partner_4_SNPs:
rs1130741; rs12440159; rs2230479; rs7495739; rs12593975; rs11633472; rs11638130; rs9673065; rs8031937; rs28928906; rs35672949; rs12913293; rs34940625; rs35459900; rs8032473; rs35210789; rs7497201; rs12915930; rs12915916; rs12914847; rs35087256; rs1127796; rs1127797; rs1128350; rs11856413; rs3935818; rs4886633; rs4886634; rs4886635; rs4886636; rs6495126; rs6495127; rs6495128; rs7497393

# Macromolecular_Interacting_Partner_4_General_References:
8307007; 10980531; 9585601; 9525984; 11350186; 12357336

# Macromolecular_Interacting_Partner_4_References:
11479276

# Macromolecular_Interacting_Partner_5_ID:
8417

# Macromolecular_Interacting_Partner_5_Name:
Glucokinase regulatory protein

# Macromolecular_Interacting_Partner_5_Synonyms:
Glucokinase regulator

# Macromolecular_Interacting_Partner_5_Gene_Name:
GCKR

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Glucokinase regulatory protein
MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEI
FQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVS
FNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISV
GLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQ
KAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFE
RAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDV
RGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIFTLDDNLTEVQ
TIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISITWPLLFFEYEGNFIQKFQREL
STKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRALAMLQRFSGQSKARCIESLLR
AIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEA
VRSALAGPGQKRTADPLEILEPDVQ

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
625

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
68686

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.68

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  enzyme regulator activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Inhibits glucokinase by forming an inactive complex with this enzyme

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
683572

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
GCKR_HUMAN (Q14397)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
GCKR

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
GCKR

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:4196

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1878 bp
ATGCCAGGCACAAAACGGTTTCAACATGTCATTGAGACCCCGGAGCCTGGCAAGTGGGAG
TTGTCTGGGTACGAGGCAGCTGTGCCAATCACGGAGAAGTCAAACCCACTGACCCAGGAT
CTAGACAAAGCAGATGCTGAGAACATTGTTCGACTGCTAGGGCAATGTGATGCTGAGATC
TTCCAGGAGGAGGGGCAAGCCCTGTCCACATACCAGAGACTCTACAGCGAATCCATTCTG
ACCACCATGGTACAGGTGGCTGGGAAAGTTCAGGAAGTGCTGAAGGAGCCAGATGGGGGG
CTGGTTGTGCTGAGTGGAGGGGGCACCTCTGGCCGGATGGCATTCCTCATGTCGGTGTCC
TTTAATCAGCTGATGAAAGGTCTGGGACAGAAACCTCTTTACACCTACCTCATTGCAGGT
GGTGACAGGTCTGTGGTGGCCTCTAGGGAGGGGACAGAAGATAGTGCCTTGCACGGGATT
GAGGAACTGAAGAAGGTGGCTGCCGGGAAGAAGAGAGTGATTGTCATTGGCATTTCTGTG
GGACTCTCTGCTCCCTTTGTGGCAGGCCAGATGGACTGCTGCATGAACAACACAGCTGTC
TTCTTGCCAGTCCTGGTTGGCTTCAATCCAGTGAGCATGGCCAGAAATGACCCCATTGAA
GACTGGAGTTCAACATTCCGACAAGTAGCAGAGCGGATGCAGAAAATGCAGGAGAAACAG
AAAGCTTTTGTGCTCAATCCTGCCATCGGGCCCGAGGGTCTCAGCGGCTCCTCCCGGATG
AAAGGTGGAAGTGCCACCAAGATTCTGCTGGAAACCCTGTTATTAGCAGCCCATAAGACT
GTGGACCAGGGCATTGCAGCATCTCAAAGATGCCTCCTGGAAATCTTGCGGACATTTGAG
CGAGCTCATCAGGTGACCTACAGCCAAAGCCCCAAGATTGCCACCCTGATGAAGAGTGTC
AGCACCAGTCTGGAGAAGAAAGGCCACGTGTACCTGGTTGGCTGGCAGACCCTGGGTATC
ATTGCCATCATGGATGGAGTAGAGTGCATCCACACCTTTGGTGCTGATTTCCGAGATGTC
CGTGGCTTTCTCATTGGTGATCACAGTGACATGTTTAACCAGAAGGCTGAGCTCACCAAC
CAGGGTCCCCAGTTCACCTTCTCCCAGGAGGACTTCCCGACTTCCATCCTTCCCTCTCTC
ACGGAAATCGATACTGTGGTCTTCATTTTCACCCTGGATGACAACCTCACGGAGGTGCAG
ACTATAGTGGAGCAGGTGAAAGAGAAGACCAACCACATCCAGGCCCTGGCACACAGCACC
GTGGGTCAGACCTTGCCGATCCCTCTGAAGAAGCTCTTTCCCTCCATCATCAGCATCACA
TGGCCACTGCTTTTCTTTGAATATGAAGGGAACTTCATCCAGAAGTTCCAGCGTGAGCTA
AGCACCAAATGGGTGCTGAATACAGTGAGTACAGGTGCTCATGTGCTTCTTGGTAAGATC
CTACAAAACCACATGTTGGACCTTCGGATTAGCAACTCCAAGCTCTTCTGGCGGGCGCTG
GCCATGCTGCAGCGGTTCTCTGGACAGTCCAAGGCTCGATGCATCGAGAGCCTCCTCCGA
GCGATCCACTTTCCCCAGCCACTGTCAGATGATATTCGGGCTGCTCCCATCTCCTGCCGT
GTCCAGGTTGCACATGAGAAGGAACAGGTGATACCCATCGCCTTGCTGAGCCTCCTATTC
CGGTGCTCGATCACTGAGGCTCAGGCACACCTGGCTGCAGCTCCTTCTGTCTGTGAGGCT
GTCAGGAGTGCTCTTGCTGGGCCAGGTCAGAAGCGCACTGCGGACCCCCTCGAGATCCTA
GAGCCTGACGTTCAGTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
Z48475

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_5_Locus:
2p23

# Macromolecular_Interacting_Partner_5_SNPs:
rs1260326; rs8179249; rs704790; rs814295; rs780094; rs715325; rs780093; rs780092; rs715326; rs1260320; rs813592; rs6735762; rs11127044; rs780095; rs7589217; rs10169261; rs8179235; rs8179213; rs8179225; rs2293571; rs11681351; rs8179219; rs8179236; rs780096; rs3817588; rs2293572; rs8179242; rs8179228; rs8179248; rs6547692; rs13394224; rs12466018; rs12471703; rs12472643; rs2032971; rs889990; rs4425043; rs8179252; rs8179251; rs34498189; rs34792470; rs8179212; rs34316866; rs8179207; rs34326658; rs41291159; rs8179239; rs8179216; rs812955; rs8179232; rs13022659; rs8179211; rs8179231; rs8179221; rs10686678; rs8179241; rs13024376; rs8179234; rs35008972; rs8179215; rs34318823; rs41291157; rs8179223; rs35843492; rs35073769; rs11393265; rs8179246; rs8179237; rs34070225; rs41291155; rs8179245; rs8179226; rs34625318; rs9711035; rs11679089; rs6744137; rs34507360; rs8179209; rs35189790; rs11295580; rs11285570; rs7422925; rs8179220; rs8179217; rs8179233; rs35372959; rs35204632; rs35348937; rs2384625; rs8179230; rs8179210; rs8179222; rs11325709; rs35738265; rs8179243; rs1270255; rs8179240; rs8179229; rs8179250; rs8179214; rs10600159; rs34648846; rs8179218; rs12475764; rs8179247; rs10549495; rs8179244; rs8179224; rs8179208; rs8179227; rs11904646; rs1260328; rs1260333; rs1647285; rs2272415; rs2288155; rs2293573; rs2303369; rs3180420; rs4270306; rs4665987; rs6707529; rs704795; rs7583698; rs780090; rs8179205; rs8179253; rs8395; rs9188; rs9974

# Macromolecular_Interacting_Partner_5_General_References:
8589523; 9570959

# Macromolecular_Interacting_Partner_5_References:
10620331

# Macromolecular_Interacting_Partner_6_ID:
8696

# Macromolecular_Interacting_Partner_6_Name:
Hexokinase domain containing 1

# Macromolecular_Interacting_Partner_6_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_6_Gene_Name:
HKDC1

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Hexokinase domain containing 1
MFAVHLMAFYFSKLKEDQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAA
VKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIR
GNGTELFEYVADCLADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGV
QDTDVVSRLTKAMRRHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYME
DMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGL
YLGELVRLILLKMAKAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLG
LEPSEADCIAVQHVCTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIH
PQYPKRLHKVVRKLVPSCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLT
REQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRV
LLVKIRSGRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFT
FSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGT
MMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDI
WTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGI
FETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAI
VEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGA
ALITAVAKRLQQAQKEN

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
917

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
102546

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
7.12

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
 Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00349:Hexokinase_1
PF03727:Hexokinase_2

# Macromolecular_Interacting_Partner_6_Signals:
Not Available

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
55665502

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
Q5VTC7_HUMAN (Q5VTC7)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
HKDC1

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
HKDC1

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:23302

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>2754 bp
ATGTTTGCGGTCCACTTGATGGCATTTTACTTCAGCAAGCTGAAGGAGGACCAGATCAAG
AAGGTGGACAGGTTCCTGTATCACATGCGGCTCTCCGATGACACCCTTTTGGACATCATG
AGGCGGTTCCGGGCTGAGATGGAGAAGGGCCTGGCAAAGGACACCAACCCCACGGCTGCA
GTGAAGATGTTGCCCACCTTCGTCAGGGCCATTCCCGATGGTTCCGAAAATGGGGAGTTC
CTTTCCCTGGATCTCGGAGGGTCCAAGTTCCGAGTGCTGAAGGTGCAAGTCGCTGAAGAG
GGGAAGCGACACGTGCAGATGGAGAGTCAGTTCTACCCAACGCCCAATGAAATCATCCGC
GGGAACGGCACAGAGCTGTTTGAATATGTAGCTGACTGTCTGGCAGATTTCATGAAGACC
AAAGATTTAAAGCATAAGAAATTGCCCCTTGGCCTAACTTTTTCTTTCCCCTGTCGACAG
ACTAAACTGGAAGAGGGTGTCCTACTTTCGTGGACAAAAAAGTTTAAGGCACGAGGAGTT
CAGGACACGGATGTGGTGAGCCGTCTGACCAAAGCCATGAGAAGACACAAGGACATGGAC
GTGGACATCCTGGCCCTGGTCAATGACACCGTGGGGACCATGATGACCTGTGCCTATGAC
GACCCCTACTGCGAAGTTGGTGTCATCATCGGAACTGGCACCAATGCGTGTTACATGGAG
GACATGAGCAACATTGACCTGGTGGAGGGCGACGAGGGCAGGATGTGCATCAACACAGAG
TGGGGGGCCTTCGGGGACGACGGGGCCCTGGAGGACATTCGCACTGAGTTCGACAGGGAG
CTGGACCTCGGCTCTCTCAACCCAGGAAAGCAACTGTTCGAGAAGATGATCAGTGGCCTG
TACCTGGGGGAGCTTGTCAGGCTTATCTTGCTGAAGATGGCCAAGGCTGGCCTCCTGTTT
GGTGGTGAGAAATCTTCTGCTCTCCACACTAAGGGCAAGATCGAAACACGGCACGTGGCT
GCCATGGAGAAGTATAAAGAAGGCCTTGCTAATACAAGAGAGATCCTGGTGGACCTGGGT
CTGGAACCGTCTGAGGCTGACTGCATTGCCGTCCAGCATGTCTGTACCATCGTCTCCTTC
CGCTCGGCCAATCTCTGTGCAGCAGCTCTGGCGGCCATCCTGACACGCCTCCGGGAGAAC
AAGAAGGTGGAACGGCTCCGGACCACAGTGGGCATGGACGGCACCCTCTACAAGATACAC
CCTCAGTACCCAAAACGCCTGCACAAGGTGGTGAGGAAACTGGTCCCAAGCTGTGATGTC
CGCTTCCTCCTGTCAGAGAGTGGCAGCACCAAGGGGGCCGCCATGGTGACCGCGGTGGCC
TCCCGCGTGCAGGCCCAGCGGAAGCAGATCGACAGGGTGCTGGCTTTGTTCCAGCTGACC
CGAGAGCAGCTCGTGGACGTGCAGGCCAAGATGCGGGCTGAGCTGGAGTATGGGCTGAAG
AAGAAGAGCCACGGGCTGGCCACGGTCAGGATGCTGCCCACCTACGTCTGCGGGCTGCCG
GACGGCACAGAGAAAGGAAAGTTTCTCGCCCTGGATCTTGGGGGAACCAACTTCCGGGTC
CTCCTGGTGAAGATCAGAAGTGGACGGAGGTCAGTGCGAATGTACAACAAGATCTTCGCC
ATCCCCCTGGAGATCATGCAGGGCACTGGTGAGGAGCTCTTTGATCACATTGTGCAGTGC
ATCGCCGACTTCCTGGACTACATGGGCCTCAAGGGAGCCTCCCTACCTTTGGGCTTCACA
TTCTCATTTCCCTGCAGGCAGATGAGCATTGACAAGGGAACACTCATAGGGTGGACCAAA
GGTTTCAAGGCCACTGACTGTGAAGGGGAGGACGTGGTGGACATGCTCAGGGAAGCCATC
AAGAGGAGAAACGAGTTTGACCTGGACATTGTTGCAGTCGTGAATGATACAGTGGGGACC
ATGATGACCTGTGGCTATGAAGATCCTAATTGTGAGATTGGCCTGATTGCAGGAACAGGC
AGCAACATGTGCTACATGGAGGACATGAGGAACATCGAGATGGTGGAGGGGGGTGAAGGG
AAGATGTGCATCAATACAGAGTGGGGAGGATTTGGAGACAATGGCTGCATAGATGACATC
TGGACCCGATACGACACGGAGGTGGATGAGGGGTCCTTGAATCCTGGCAAGCAGAGATAC
GAGAAAATGACCAGTGGGATGTACTTGGGGGAGATTGTGCGGCAGATCCTGATCGACCTG
ACCAAGCAGGGTCTCCTCTTCCGAGGGCAGATTTCAGAGCGTCTCCGGACCAGGGGCATC
TTCGAAACCAAGTTCCTGTCCCAGATCGAAAGCGATCGGCTGGCCCTTCTCCAGGTCAGG
AGGATTCTGCAGCAGCTGGGCCTGGACAGCACGTGTGAGGACAGCATCGTGGTGAAGGAG
GTGTGCGGAGCCGTGTCCCGGCGGGCGGCCCAGCTCTGCGGTGCTGGCCTGGCCGCTATA
GTGGAAAAAAGGAGAGAAGACCAGGGGCTAGAGCACCTGAGGATCACTGTGGGTGTGGAC
GGCACCCTGTACAAGCTGCACCCTCACTTTTCTAGAATATTGCAGGAAACTGTGAAGGAA
CTAGCCCCTCGATGTGATGTGACATTCATGCTGTCAGAAGATGGCAGTGGAAAAGGGGCA
GCACTGATCACTGCTGTGGCCAAGAGGTTACAGCAGGCACAGAAGGAGAACTAG

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
AL596223

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_6_Locus:
10q21.3

# Macromolecular_Interacting_Partner_6_SNPs:
rs906219; rs874556; rs7899445; rs10823320; rs1111335; rs5030948; rs2611; rs4746832; rs3740601; rs1472814; rs2102339; rs874557; rs7089312; rs5030946; rs10998677; rs7075720; rs5030971; rs4145930; rs7904936; rs4746825; rs5030972; rs2394529; rs953724; rs10762268; rs4746828; rs5030944; rs2279927; rs5030970; rs1983128; rs7923953; rs7918272; rs925024; rs4746823; rs10823322; rs10998673; rs4072135; rs1027793; rs10823324; rs4075240; rs10823321; rs3740600; rs11812911; rs10998657; rs7073527; rs10762271; rs10762266; rs4746826; rs12359891; rs7091503; rs11813186; rs1472815; rs4746824; rs2279930; rs4746827; rs4072136; rs10128506; rs7101003; rs9663238; rs7092167; rs2394532; rs10082520; rs7085830; rs10762269; rs7900049; rs5030941; rs9645499; rs7903151; rs7083041; rs9645501; rs12246517; rs7068302; rs10998679; rs7091301; rs4746830; rs4746822; rs12573801; rs10823325; rs12257901; rs1021964; rs10762267; rs7091496; rs10128247; rs4746831; rs7918950; rs7089277; rs5030945; rs12573334; rs7082043; rs10762270; rs7069745; rs6480393; rs9665513; rs7919018; rs7091623; rs2394531; rs5030973; rs10998656; rs16926201; rs7918356; rs1983127; rs9645500; rs12253517; rs12778771; rs10732416; rs16926175; rs1106676; rs7091505; rs12261533; rs10762265; rs9663245; rs12221182; rs17566219; rs10998665; rs2279929; rs4745978; rs3740599; rs11814510; rs10998654; rs10998658; rs10823319; rs11814154; rs7907764; rs10823326; rs10823323; rs16926179; rs12253459; rs7899214; rs7097447; rs7896577; rs10998659; rs5030913; rs12241551; rs10082355; rs4746829; rs2394530; rs17566597; rs1911225; rs12358818; rs10466014; rs11817458; rs12781552; rs10998681; rs2063046; rs4745977; rs10823318; rs17566087; rs35542013; rs35746503; rs35008643; rs10998655; rs35305687; rs36205722; rs34566173; rs9703909; rs5785902; rs35934642; rs10998670; rs11446919; rs5785906; rs41314996; rs34401681; rs35310351; rs10998663; rs12355552; rs2002012; rs10998680; rs3998838; rs36067150; rs11813849; rs12358100; rs34861627; rs7917665; rs5785903; rs3740598; rs41279652; rs10998660; rs12768756; rs35672201; rs10998669; rs10998652; rs10998653; rs33937984; rs35796674; rs9645491; rs7914955; rs5785901; rs34028207; rs35748446; rs11294938; rs7923780; rs5030942; rs12268341; rs10619082; rs34970065; rs10998664; rs10556473; rs35255281; rs11816618; rs5030947; rs2894079; rs5785905; rs7910341; rs35523344; rs35696875; rs10524347; rs10604848; rs7095933; rs12217871; rs34634483; rs10647584; rs41279650; rs36003926; rs10998675; rs33955218; rs35614872; rs10998662; rs12768466; rs1967236; rs35199395; rs35420545; rs7917667; rs10128502; rs11348828; rs10998672; rs11341726; rs35691716; rs10998674; rs10998666; rs7092458; rs10646729; rs33969502; rs5030914; rs12358099; rs34746150; rs34668088; rs5785907; rs34529083; rs5785900; rs12248244; rs11340954; rs34459941; rs34306910; rs41304621; rs35015670; rs10647585; rs12780191; rs33974062; rs10998678; rs34801386; rs12360007; rs5785904; rs3086579; rs34225892; rs10650414; rs11373074; rs9665642; rs10998667; rs11599918; rs12765400; rs10998671; rs35204234; rs10740318; rs10762263; rs10762264; rs10998643; rs10998646; rs10998647; rs10998686; rs12241136; rs1472816; rs1472818; rs2394534; rs2394538; rs34516964; rs35372667; rs5030933; rs5030937; rs5030938; rs5030939; rs5030940

# Macromolecular_Interacting_Partner_6_General_References:
Not Available

# Macromolecular_Interacting_Partner_6_References:
Not Available

# Macromolecular_Interacting_Partner_7_ID:
8879

# Macromolecular_Interacting_Partner_7_Name:
Glucosamine-6-phosphate deaminase 2 variant

# Macromolecular_Interacting_Partner_7_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Glucosamine6phosphate deaminase 2 variant
GRSRVVGCCLFPLFQRRRTIGSAGLNLFWKLCVTVMRLVILDNYDLASEWAAKYICNRII
QFKPGQDRYFTLGLPTGSTPLGCYKKLIEYHKNGHLSFKYVKTFNMDEYVGLPRNHPESY
HSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIA
FNEPGSSLVSRTRLKTLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITG
AHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCDEDATLELRVKTVKYFKGEH

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
294

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
33110

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
8.07

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
 Function:  catalytic activity
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, interconverting aldoses and ketoses
Function:  glucosamine-6-phosphate deaminase activity
 ||
>>>
 Process:  nitrogen compound metabolism
Process:  amine metabolism
Process:  amino sugar metabolism
Process:  glucosamine metabolism
Process:  N-acetylglucosamine metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_7_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF01182:Glucosamine_iso

# Macromolecular_Interacting_Partner_7_Signals:
1-41

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
62089394

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
Q59EA7_HUMAN (Q59EA7)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:21526

# Macromolecular_Interacting_Partner_7_PDB_ID:
1NE7

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>887 bp
GGGGTCGCTCTCGGGTGGTTGGGTGTTGCTTGTTCCCGCTGTTCCAGCGTCGAAGAACCA
TTGGGTCTGCCGGTTTGAACTTGTTCTGGAAGCTGTGCGTCACCGTAATGAGGCTTGTAA
TTCTTGATAACTATGACTTGGCTAGTGAATGGGCAGCCAAATACATCTGTAATCGCATCA
TTCAGTTCAAACCTGGACAGGACAGATATTTTACACTGGGTTTACCAACAGGGAGTACAC
CTTTAGGATGCTATAAAAAACTAATAGAATATCATAAGAATGGACACCTTTCTTTTAAAT
ATGTGAAGACCTTTAATATGGATGAATATGTAGGACTTCCAAGAAATCATCCTGAAAGCT
ACCATTCTTATATGTGGAATAATTTTTTTAAGCATATCGATATAGATCCTAATAATGCAC
ATATCCTTGACGGGAATGCTGCAGATTTACAAGCAGAATGTGATGCTTTTGAAAACAAAA
TAAAAGAAGCTGGAGGAATAGATCTTTTTGTTGGAGGAATTGGTCCAGATGGTCATATCG
CTTTCAATGAGCCTGGATCCAGTTTAGTGTCAAGGACAAGATTAAAGACTCTAGCAATGG
ATACCATCTTGGCAAATGCCAAATATTTTGATGGAGATTTATCAAAAGTGCCAACTATGG
CTCTAACTGTTGGTGTGGGGACAGTGATGGATGCTAGAGAAGTAATGATCCTTATAACAG
GGGCACACAAGGCATTTGCCCTGTACAAAGCAATAGAAGAAGGAGTCAATCACATGTGGA
CTGTTTCCGCTTTCCAGCAGCATCCCCGGACTATTTTTGTATGCGATGAAGATGCTACTT
TAGAATTAAGAGTTAAAACTGTGAAATACTTTAAAGGTGAGCACTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
AB209904

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Locus:
Not Available

# Macromolecular_Interacting_Partner_7_SNPs:
Not Available

# Macromolecular_Interacting_Partner_7_General_References:
Not Available

# Macromolecular_Interacting_Partner_7_References:
Not Available

End of HMDB00124

Beginning of HMDB00125
# Accession_No:
HMDB00125

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-19 15:40:57

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Glutathione

# Description:
Glutathione is a compound synthesized from cysteine, perhaps the most important member of the body's toxic waste disposal team. Like cysteine, glutathione contains the crucial thiol (-SH) group that makes it an effective antioxidant. There are virtually no living organisms on this planet-animal or plant whose cells don't contain some glutathione. Scientists have speculated that glutathione was essential to the very development of life on earth. Glutathione has many roles; in none does it act alone. It is a coenzyme in various enzymatic reactions. The most important of these are redox reactions, in which the thiol grouping on the cysteine portion of cell membranes protects against peroxidation; and conjugation reactions, in which glutathione (especially in the liver) binds with toxic chemicals in order to detoxify them. Glutathione is also important in red and white blood cell formation and throughout the immune system. Glutathione's clinical uses include the prevention of oxygen toxicity in hyperbaric oxygen therapy, treatment of lead and other heavy metal poisoning, lowering of the toxicity of chemotherapy and radiation in cancer treatments, and reversal of cataracts.  (http://www.dcnutrition.com/AminoAcids/) Glutathione participates in leukotriene synthesis and is a cofactor for the enzyme glutathione peroxidase. It is also important as a hydrophilic molecule that is added to lipophilic toxins and waste in the liver during biotransformation before they can become part of the bile. Glutathione is also needed for the detoxification of methylglyoxal, a toxin produced as a by-product of metabolism. This detoxification reaction is carried out by the glyoxalase system. Glyoxalase I (EC 4.4.1.5) catalyzes the conversion of methylglyoxal and reduced glutathione to S-D-Lactoyl-glutathione. Glyoxalase II (EC 3.1.2.6) catalyzes the hydrolysis of S-D-Lactoyl-glutathione to glutathione and D-lactate. GSH is known as a substrate in both conjugation reactions and reduction reactions, catalyzed by glutathione S-transferase enzymes in cytosol, microsomes, and mitochondria. However, it is also capable of participating in non-enzymatic conjugation with some chemicals, as in the case of n-acetyl-p-benzoquinone imine (NAPQI), the reactive cytochrome P450-reactive metabolite formed by acetaminophen, that becomes toxic when GSH is depleted by an overdose (of acetaminophen). Glutathione in this capacity binds to NAPQI as a suicide substrate and in the process detoxifies it, taking the place of cellular protein thiol groups which would otherwise be covalently modified; when all GSH has been spent, NAPQI begins to react with the cellular proteins, killing the cells in the process. The preferred treatment for an overdose of this painkiller is the administration (usually in atomized form) of N-acetylcysteine, which is used by cells to replace spent GSSG and renew the usable GSH pool. (http://en.wikipedia.org/wiki/Glutathione)

# Synonyms:
5-L-Glutamyl-L-cysteinylglycine; Agifutol S; Copren; Deltathione; GSH; Glutathion; Glutathione; Glutathione red; Glutathione reduced; Glutathione-SH; Glutatiol; Glutatione; Glutide; Glutinal; Isethion; L-Glutathione; L-Glutathione reduce; L-gamma-glutamyl-L-cysteinylglycine; L-glutamyl-L-cysteinylglycine; Ledac; Neuthion; Reduced glutathione; Tathion; Tathione; Triptide; gamma-Glutamylcysteinylglycine; gamma-L-Glutamyl-L-cysteinylglycine; gamma-L-glutamyl-L-cysteinyl-glycine; red. glutathione

# Chemical_IUPAC_Name:
(2S)-2-amino-4-[[(1R)-1-(carboxymethylcarbamoyl)-2-sulfanyl-ethyl]carbamoyl]butanoic acid

# Chemical_Formula:
C10H17N3O6S

# Chemical_Structure:
tbl_chemical:::HMDB00125_ZOOM.png:::119283203735694118

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00125_THUMB.png:::119283203532359915

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid; secondary carboxylic acid amide; thiol (sulfanyl compound); alkylthiol; alpha-aminoacid

# Taxonomy_Biofunction:
Component of Glutamate metabolism; Component of Glutathione metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
307.08380

# Molecular_Weight_Avg:
307.32349

# Smiles_String_isomeric:
N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O

# Smiles_String_canonical:
NC(CCC(=O)NC(CS)C(=O)NCC(O)=O)C(O)=O

# KEGG_Compound_ID:
C00051

# BioCyc_ID:
OXIDIZED-GLUTATHIONE

# PubChem_CID:
124886

# PubChem_SID:
821009; 584479; 823079; 11360489; 821000; 820985; 11494233; 854378; 6435995; 825748; 829618; 836582; 8022090; 832657; 11537708; 823938; 818856; 826520; 7847082; 823937; 10318190; 825543; 11335250; 831498; 584925; 3353; 821976; 823921; 823941; 7854181; 585393; 11533291; 819491; 11110093; 828542; 818762; 836434; 829651; 836436; 11376599; 584411; 833160; 3133343; 824192; 837543; 10318559; 820159; 11489316; 841095; 11365875; 855260; 821975; 830887; 11374491; 11368437; 818780; 8025524; 11490761; 821984; 11461461; 829059; 835368; 7887988; 838218; 11485255; 836320; 597405; 11492870; 837358; 830860; 821977; 828541; 838765; 820986; 823940; 836441; 829899; 10241198; 823951; 820961; 8149865; 11363313; 11372111; 836516; 829901; 821064; 10486585; 823584; 820966; 826518; 838751; 834720; 824837; 585424; 823080; 834937; 834655

# OMIM_ID:
138300; 138320; 231950

# Metagene_ID:
gamma-GLUTAMYL-TRANSPEPTIDASE DEFICIENCY: 499; GLUTATHIONE SYNTHETASE DEFICIENCY: 19

# BiGG_ID:
33669

# Wikipedia_ID:
Glutathione

# METLIN_ID:
44

# Ref_ID:
16780237; 11978879; 16270397; 16089347; 16650398; 12938853; 16316931; 15702405; 16877380; 16379316; 15882454; 16404476; 16376049; 16112416; 16105090; 16806086; 16099321; 16391576; 16472997; 16621738

# ChEBI_ID:
16856

# CAS_Registry_Number:
70-18-8

# InChI:
InChI=1/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1

# Synthesis_Reference:
Not Available

# Melting_Point:
195 oC

# Melting_Point_predicted:
69.4 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
292.5 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
1000.0 mg/mL at 25 oC [MEYLAN,WM et al. (1996)]; 0.879 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.73 [Predicted by ALOGPS]; -6.4 [Predicted by PubChem via XLOGP]; -5.41 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Glutathione.pdf:::1132562203293964863

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00125.mol:::117503925615826906

# SDF_File_[Text]:
tbl_chemical:::HMDB00125.sdf:::119283203096523741

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00125.pdb:::119283203393624383

# PDB_ID:
11GS

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::041017_P00_04_HW_1DC_106.jpg:::114168460019538698

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041017_P00_04_HW_1DC_106.zip:::114168460016689601

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041017_P00_04_HW_1DC_106_Assigned.jpg:::115983224180976163

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041017_P00_04_HW_2DHSQC_379.jpg:::11461789553266468

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041017_P00_04_HW_2DHSQC_379.zip:::114617895533477960

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041017_P00_04_HW_2DHSQC_379_Assigned.jpg:::115879031148371136

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Glutathione.gif:::1132732111437478812

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00125_peaks.txt:::1156309560662770315

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Glutathione_C.gif:::1132737691977634745

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00125_peaks.txt:::1156310750727231268

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00125L.png:::117555261968030965; Medium Energy:tbl_ms:::HMDB00125M.png:::117555267081846664; High Energy:tbl_ms:::HMDB00125H.png:::117555270959345454

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP); endoplasmic reticulum; Extracellular; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Cellular Cytoplasm; Mucus; Saliva; Urine

# Concentration_[Normal]:
Urine	0.065	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	15702405
Blood	3.21+/- 1.50	uM	Adult:>18_yrs_old	Both	Normal	15882454
Blood	1090.0 +/- 200.0	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 85-97. Edited by Cornelius Lentner. ; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. ; Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	1.2 +/- 0.16	umol/L	Adult:>18_yrs_old	N/A	Normal	11978879
Cellular_Cytoplasm	3210 (1710-4710)	umol/L	Adult:>18_yrs_old	Both	Normal	15882454


# Concentration_[Abnormal]:
Cerebrospinal_Fluid(CSF)	0.19 +/- 0.05	umol/L	N/A	N/A	Traumatic Brain Injury	11978879
Cerebrospinal_Fluid(CSF)	4.56 +/- 0.7	umol/L	Adult:>18_yrs_old	N/A	Multiple Sclerosis under treatment with Acetyl-L-carnitine	12938853
Cerebrospinal_Fluid(CSF)	2.58 +/- 1.2	umol/L	Adult:>18_yrs_old	N/A	Multiple Sclerosis	12938853


# Associated_Disorders:
Alzheimer's Disease; Gamma-glutamyl-transpeptidase Deficiency; Glutathione Synthetase Deficiency; Hyperglycemia; Multiple Sclerosis; Multiple Sclerosis under treatment with Acetyl-L-carnitine; Traumatic Brain Injury; Vitamin B6 Deficiency

# Pathway_Names:
Glutathione metabolism;Lysine degradation;One carbon pool by folate;Purine metabolism;Alanine and aspartate metabolism;D-Arginine and D-ornithine metabolism

# Pathway_Images:
;Lysine_degradation.jpg;;Purine_Synthesis.jpg;Aspartate_and_Alanine_metabolism.jpg;

# KEGG_Images:
map00480;map00310;map00670;map00230;map00252;map00472

# Pathway_Graphs:
;Lysine_degradation_Graph.jpg;;Purine_Synthesis_Graph.jpg;Aspartate_and_Alanine_metabolism_Graph.jpg;

# Pathway_SBMLs:
;Lysine_degradation.xml;;Purine_Synthesis.xml;Aspartate_and_Alanine_metabolism.xml;

# Metabolic_Enzyme_1_ID:
6069

# Metabolic_Enzyme_1_Name:
Serine--pyruvate aminotransferase

# Metabolic_Enzyme_1_Synonyms:
SPT; Alanine-- glyoxylate aminotransferase; AGT

# Metabolic_Enzyme_1_Gene_Name:
AGXT

# Metabolic_Enzyme_1_Protein_Sequence:
>Serinepyruvate aminotransferase
MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEI
KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG
ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLL
LVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF
YLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHG
RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLR
IGLLGCNATRENVDRVTEALRAALQHCPKKKL

# Metabolic_Enzyme_1_Number_of_Residues:
392

# Metabolic_Enzyme_1_Molecular_Weight:
43011

# Metabolic_Enzyme_1_Theoretical_pI:
8.55

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
L-serine + pyruvate = 3-hydroxypyruvate + L- alanine

# Metabolic_Enzyme_1_Pathway:
map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_1_Reaction:
L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00266:Aminotran_5

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.6.1.51;EC 2.6.1.44

# Metabolic_Enzyme_1_GenBank_ID_Protein:
36582

# Metabolic_Enzyme_1_SwissProt_ID:
SPYA_HUMAN (P21549)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
AGXT

# Metabolic_Enzyme_1_Geneatlas_id:
AGXT

# Metabolic_Enzyme_1_hgnc_id:
HGNC:341

# Metabolic_Enzyme_1_PDB_ID:
1H0C

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Peroxisome. Note=Except in some PH1 patients where AGT is found in the mitochondrial matrix

# Metabolic_Enzyme_1_Gene_Sequence:
>1179 bp
ATGGCCTCTCACAAGCTGCTGGTGACCCCCCCCAAGGCCCTGCTCAAGCCCCTCTCCATC
CCCAACCAGCTCCTGCTGGGGCCTGGTCCTTCCAACCTGCCTCCTCGCATCATGGCAGCC
GGGGGGCTGCAGATGATCGGGTCCATGAGCAAGGATATGTACCAGATCATGGACGAGATC
AAGGAAGGCATCCAGTACGTGTTCCAGACCAGGAACCCACTCACACTGGTCATCTCTGGC
TCGGGACACTGTGCCCTGGAGGCCGCCCTGGTCAATGTGCTGGAGCCTGGGGACTCCTTC
CTGGTTGGGGCCAATGGCATTTGGGGGCAGCGAGCCGTGGACATCGGGGAGCGCATAGGA
GCCCGAGTGCACCCGATGACCAAGGACCCTGGAGGCCACTACACACTGCAGGAGGTGGAG
GAGGGCCTGGCCCAGCACAAGCCAGTGCTGCTGTTCTTAACCCACGGGGAGTCGTCCACC
GGCGTGCTGCAGCCCCTTGATGGCTTCGGGGAACTCTGCCACAGGTACAAGTGCCTGCTC
CTGGTGGATTCGGTGGCATCCCTGGGCGGGACCCCCCTTTACATGGACCGGCAAGGCATC
GACATCCTGTACTCGGGCTCCCAGAAGGCCCTGAACGCCCCTCCAGGGACCTCGCTCATC
TCCTTCAGTGACAAGGCCAAAAAGAAGATGTACTCCCGCAAGACGAAGCCCTTCTCCTTC
TACCTGGACATCAAGTGGCTGGCCAACTTCTGGGGCTGTGACGACCAGCCCAGGATGTAC
CATCACACAATCCCCGTCATCAGCCTGTACAGCCTGAGAGAGAGCCTGGCCCTCATTGCG
GAACAGGGCCTGGAGAACAGCTGGCGCCAGCACCGCGAGGCCGCGGCGTATCTGCATGGG
CGCCTGCAGGCACTGGGGCTGCAGCTCTTCGTGAAGGACCCGGCGCTCCGGCTTCCCACA
GTCACCACTGTGGCTGTACCCGCTGGCTATGACTGGAGAGACATCGTCAGCTACGTCATA
GACCACTTCGACATTGAGATCATGGGTGGCCTTGGGCCCTCCACGGGGAAGGTGCTGCGG
ATCGGCCTGCTGGGCTGCAATGCCACCCGCGAGAATGTGGACCGCGTGACGGAGGCCCTG
AGGGCGGCCCTGCAGCACTGCCCCAAGAAGAAGCTGTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X56092

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_1_Locus:
2q36-q37

# Metabolic_Enzyme_1_SNPs:
rs4426527; rs13408961; rs34885252; rs34116584; rs33958047; rs4273214; rs4344931; rs4073369; rs4073370; rs12695032; rs6732985; rs4073597; rs10199038; rs11681134; rs11894759; rs12478859; rs10933640; rs4355101; rs13430507; rs13423821; rs5021686; rs5013752; rs11901056; rs11687303; rs10933641; rs13030904; rs11693280; rs11685698; rs11886288; rs4675876; rs4675875; rs4234095; rs10182575; rs34664134; rs35977912; rs35698882; rs3196760; rs4991357; rs11682457; rs11688815; rs11691745; rs35882315; rs12997245; rs4991356; rs33996129; rs6722479; rs4991354; rs4414673; rs5839789; rs35937797; rs12464426; rs4991360; rs34134404; rs35561942; rs4991355; rs5839787; rs34995778; rs34572785; rs10196315; rs13020254; rs11691886; rs35566646; rs5839788; rs4257395; rs4991359; rs5013751; rs4328626; rs4991361; rs35172778; rs5839786; rs4991358; rs5021687; rs4675793; rs12622523; rs34927888; rs12998301; rs11897804; rs7568864; rs4675877; rs6718131; rs35931917; rs35082207; rs12619921; rs6717643; rs10177846; rs10178744; rs10185214; rs10933510; rs1138103; rs11680732; rs11681382; rs11686679; rs11689640; rs11886874; rs11899555; rs12616061; rs12991730; rs12994627; rs13000529; rs13001584; rs13007644; rs13025495; rs13030611; rs13385816; rs13387029; rs13397515; rs13410652; rs33998315; rs34927891; rs36014033; rs4129624; rs4295000; rs4311055; rs4312490; rs4465762; rs4538195; rs4675792; rs4675869; rs4675871; rs4675872; rs4675874; rs6437372; rs6707763; rs6708304; rs6741220; rs6744422; rs7340215; rs7340501; rs7355583; rs7557279; rs7590032; rs7598309; rs7600847; rs7601670; rs7604393; rs7606856; rs9288742

# Metabolic_Enzyme_1_General_References:
2253628; 1703535; 2363689; 2045108; 2039493; 1349575; 1301173; 8101040; 8507692; 9192270; 10394939; 10862087

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6071

# Metabolic_Enzyme_2_Name:
Glutathione synthetase

# Metabolic_Enzyme_2_Synonyms:
Glutathione synthase; GSH synthetase; GSH-S

# Metabolic_Enzyme_2_Gene_Name:
GSS

# Metabolic_Enzyme_2_Protein_Sequence:
>Glutathione synthetase
MATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSA
LLEQAYAVQMDFNLLVDAVSQNAAFLEQTLSSTIKQDDFTARLFDIHKQVLKEGIAQTVF
LGLNRSDYMFQRSADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLSKTKEAGKIL
SNNPSKGLALGIAKAWELYGSPNALVLLIAQEKERNIFDQRAIENELLARNIHVIRRTFE
DISEKGSLDQDRRLFVDGQEIAVVYFRDGYMPRQYSLQNWEARLLLERSHAAKCPDIATQ
LAGTKKVQQELSRPGMLEMLLPGQPEAVARLRATFAGLYSLDVGEEGDQAIAEALAAPSR
FVLKPQREGGGNNLYGEEMVQALKQLKDSEERASYILMEKIEPEPFENCLLRPGSPARVV
QCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYPV

# Metabolic_Enzyme_2_Number_of_Residues:
474

# Metabolic_Enzyme_2_Molecular_Weight:
52385

# Metabolic_Enzyme_2_Theoretical_pI:
5.73

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  acid-amino acid ligase activity
Function:  glutathione synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  cofactor metabolism
Process:  coenzyme metabolism
Process:  glutathione metabolism
Process:  glutathione biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione

# Metabolic_Enzyme_2_Pathway:
map00251  Glutamate metabolism;
 map00480  Glutathione metabolism

# Metabolic_Enzyme_2_Reaction:
ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF03917:GSH_synth_ATP;
PF03199:GSH_synthase

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 6.3.2.3

# Metabolic_Enzyme_2_GenBank_ID_Protein:
886284

# Metabolic_Enzyme_2_SwissProt_ID:
GSHB_HUMAN (P48637)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
GSS

# Metabolic_Enzyme_2_Geneatlas_id:
GSS

# Metabolic_Enzyme_2_hgnc_id:
HGNC:4624

# Metabolic_Enzyme_2_PDB_ID:
2HGS

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>1425 bp
ATGGCCACCAACTGGGGGAGCCTCTTGCAGGATAAACAGCAGCTAGAGGAGCTGGCACGG
CAGGCCGTGGACCGGGCCCTGGCTGAGGGAGTATTGCTGAGGACCTCACAGGAGCCCACT
TCCTCGGAGGTGGTGAGCTATGCCCCATTCACGCTCTTCCCCTCACTGGTCCCCAGTGCC
CTGCTGGAGCAAGCCTATGCTGTGCAGATGGACTTCAACCTGCTAGTGGATGCTGTCAGC
CAGAACGCTGCCTTCCTGGAGCAAACTCTTTCCAGCACCATCAAACAGGATGACTTTACC
GCTCGTCTCTTTGACATCCACAAGCAAGTCCTAAAAGAGGGCATTGCCCAGACTGTGTTC
CTGGGCCTGAATCGCTCAGACTACATGTTCCAGCGCAGCGCAGATGGCTCCCCAGCCCTG
AAACAGATCGAAATCAACACCATCTCTGCCAGCTTTGGGGGCCTGGCCTCCCGGACCCCA
GCTGTGCACCGACATGTTCTCAGTGTCCTGAGTAAGACCAAAGAAGCTGGCAAGATCCTC
TCTAATAATCCCAGCAAGGGACTGGCCCTGGGAATTGCCAAAGCCTGGGAGCTCTACGGC
TCACCCAATGCTCTGGTGCTACTGATTGCTCAAGAGAAGGAAAGAAACATATTTGACCAG
CGTGCCATAGAGAATGAGCTACTGGCCAGGAACATCCATGTGATCCGACGAACATTTGAA
GATATCTCTGAAAAGGGGTCTCTGGACCAAGACCGAAGGCTGTTTGTGGATGGCCAGGAA
ATTGCTGTGGTTTACTTCCGGGATGGCTACATGCCTCGTCAGTACAGTCTACAGAATTGG
GAAGCACGTCTACTGCTGGAGAGGTCACATGCTGCCAAGTGCCCAGACATTGCCACCCAG
CTGGCTGGGACTAAGAAGGTGCAGCAGGAGCTAAGCAGGCCGGGCATGCTGGAGATGTTG
CTCCCTGGCCAGCCTGAGGCTGTGGCCCGCCTCCGCGCCACCTTTGCTGGCCTCTACTCA
CTGGATGTGGGTGAAGAAGGGGACCAGGCCATCGCCGAGGCCCTTGCTGCCCCTAGCCGG
TTTGTGCTAAAGCCCCAGAGAGAGGGTGGAGGTAACAACCTATATGGGGAGGAAATGGTA
CAGGCCCTGAAACAGCTGAAGGACAGTGAGGAGAGGGCCTCCTACATCCTCATGGAGAAG
ATCGAACCTGAGCCTTTTGAGAATTGCCTGCTACGGCCTGGCAGCCCTGCCCGAGTGGTC
CAGTGCATTTCAGAGCTGGGCATCTTTGGGGTCTATGTCAGGCAGGAAAAGACACTCGTG
ATGAACAAGCACGTGGGGCATCTACTTCGAACCAAAGCCATCGAGCATGCAGATGGTGGT
GTGGCAGCGGGAGTGGCAGTCCTGGACAACCCATACCCTGTGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
L42531

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_2_Locus:
20q11.2

# Metabolic_Enzyme_2_SNPs:
rs11905938; rs2025096; rs6058146; rs17310328; rs12106012; rs12106084; rs6060128; rs17092185; rs6088660; rs6088659; rs35747685; rs35401456; rs34828551; rs35024451; rs34424190; rs34197261; rs6088658; rs35242933; rs2273684; rs1801310; rs6088655; rs7262107; rs6060124; rs4911452; rs2236270; rs6060127; rs2378261; rs11167248; rs2065003; rs6087653; rs8124933; rs6088653; rs6119545; rs7265992; rs6087652; rs6088657; rs6087651; rs734111; rs2236271; rs17092180; rs6087654; rs6142264; rs34286188; rs34158986; rs35789023; rs35416056; rs34681587; rs34436718; rs35333051; rs34275953; rs8116746; rs34244243; rs36033330; rs35095077; rs35546710; rs35332752; rs34138151; rs11906565; rs35291022; rs6060120; rs35515472; rs34053903; rs34526995; rs34174778; rs35552264; rs35492041; rs7268769; rs3761144; rs35554478; rs13041792; rs35409039; rs11556224; rs28936396; rs34852238; rs34239729; rs35051256; rs2025097; rs6119546; rs6088652; rs35312031; rs36000727; rs35436858; rs34058755; rs34695538; rs4911453; rs4911454; rs1051103; rs6060129; rs36110693; rs36066003; rs35530012; rs34799519; rs1051118; rs9369; rs1063574; rs34120465; rs36088358; rs11483006; rs11479510; rs8118735; rs11426955; rs7363022; rs34843909; rs36089768; rs34585562; rs13044537; rs11429240; rs34687164; rs34781494; rs35865417; rs34018529; rs34600433; rs35351954; rs34897984; rs6120765; rs35986481; rs35660796; rs34606182; rs34739274; rs6088656; rs6141521; rs35132658; rs6060125; rs34457683; rs35595300; rs7343400; rs36066117; rs11433142; rs13039821; rs6060122; rs35990489; rs35898203; rs11411767; rs13040526; rs34209721; rs41303799; rs6058145; rs34632033; rs11453665; rs34669462; rs35600676; rs34315595; rs35487260; rs6087655; rs35228406; rs6060121; rs35270925; rs34436391; rs34233448; rs34331049; rs35878299; rs7344898; rs6120766; rs35928385; rs11349896; rs11413498; rs35607184; rs7351715; rs6058144; rs33967485; rs35188973; rs34041698; rs6142265; rs34006566; rs35274316; rs11482121; rs34433793; rs36048676; rs7264920; rs12162462; rs34413947; rs13040393; rs35405069; rs6088654; rs6120767; rs35147036; rs34526380; rs36021884; rs35794011; rs13044412; rs35294917; rs7266596; rs35285939; rs35976778; rs3787212; rs13036630; rs6087656; rs36208521; rs34293667; rs36208864; rs35828152; rs34864006; rs11700037; rs10427424; rs10427446; rs10485507; rs11699241; rs11905995; rs17092174; rs17309872; rs17310467; rs17401737; rs2076667; rs2223881; rs2378263; rs3746450; rs3761143; rs3818273; rs4911165; rs4911449; rs4911450; rs4911451; rs6058147; rs6060130; rs6088649; rs6088650; rs6088651; rs6088662; rs6088663; rs6088664; rs6119547; rs6120764; rs6120768; rs6141522; rs6142263; rs725521; rs7260994; rs8119110; rs8183627

# Metabolic_Enzyme_2_General_References:
7646467; 11780052; 8896573; 9215686

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6072

# Metabolic_Enzyme_3_Name:
Serine hydroxymethyltransferase, mitochondrial precursor

# Metabolic_Enzyme_3_Synonyms:
Serine methylase; Glycine hydroxymethyltransferase; SHMT

# Metabolic_Enzyme_3_Gene_Name:
SHMT2

# Metabolic_Enzyme_3_Protein_Sequence:
>Serine hydroxymethyltransferase, mitochondrial precursor
MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELL
QREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQ
RRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV
KRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREV
CDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVD
PKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARA
MADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAIT
PGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQ
RLANLRQRVEQFARAFPMPGFDEH

# Metabolic_Enzyme_3_Number_of_Residues:
504

# Metabolic_Enzyme_3_Molecular_Weight:
55994

# Metabolic_Enzyme_3_Theoretical_pI:
8.67

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  glycine hydroxymethyltransferase activity
 ||
>>>
Process:  L-serine metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Interconversion of serine and glycine

# Metabolic_Enzyme_3_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00310  Lysine degradation;
 map00460  Cyanoamino acid metabolism;
 map00670  One carbon pool by folate;
 map00680  Methane metabolism

# Metabolic_Enzyme_3_Reaction:
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00464:SHMT

# Metabolic_Enzyme_3_Signals:
1-18

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.1.2.1

# Metabolic_Enzyme_3_GenBank_ID_Protein:
746436

# Metabolic_Enzyme_3_SwissProt_ID:
GLYM_HUMAN (P34897)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
SHMT2

# Metabolic_Enzyme_3_Geneatlas_id:
SHMT2

# Metabolic_Enzyme_3_hgnc_id:
HGNC:10852

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_3_Gene_Sequence:
>1452 bp
ATGGCCATTCGGGCTCAGCACAGCAACGCAGCCCAGACTCAGACTGGGGAAGCAAACAGG
GGCTGGACAGGCCAGGAGAGCCTGTCGGACAGTGATCCTGAGATGTGGGAGTTGCTGCAG
AGGGAGAAGGACAGGCAGTGTCGTGGCCTGGAGCTCATTGCCTCAGAGAACTTCTGCAGC
CGAGCTGCGCTGGAGGCCCTGGGGTCCTGTCTGAACAACAAGTACTCGGAGGGTTATCCT
GGCAAGAGATACTATGGGGGAGCAGAGGTGGTGGATGAAATTGAGCTGCTGTGCCAGCGC
CGGGCCTTGGAAGCCTTTGACCTGGATCCTGCACAGTGGGGAGTCAATGTCCAGCCCTAC
TCCGGGTCCCCAGCCAACCTGGCCGTCTACACAGCCCTTCTGCAACCTCACGACCGGATC
ATGGGGCTGGACCTGCCCGATGGGGGCCATCTCACCCACGGCTACATGTCTGACGTCAAG
CGGATATCAGCCACGTCCATCTTCTTCGAGTCTATGCCCTATAAGCTCAACCCCAAAACT
GGCCTCATTGACTACAACCAGCTGGCACTGACTGCTCGACTTTTCCGGCCACGGCTCATC
ATAGCTGGCACCAGCGCCTATGCTCGCCTCATTGACTACGCCCGCATGAGAGAGGTGTGT
GATGAAGTCAAAGCACACCTGCTGGCAGACATGGCCCACATCAGTGGCCTGGTGGCTGCC
AAGGTGATTCCCTCGCCTTTCAAGCACGCGGACATCGTCACCACCACTACTCACAAGACT
CTTCGAGGGGCCAGGTCAGGGCTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGGACCCC
AAGACTGGCCGGGAGATCCCTTACACATTTGAGGACCGAATCAACTTTGCCGTGTTCCCA
TCCCTGCAGGGGGGCCCCCACAATCATGCCATTGCTGCAGTAGCTGTGGCCCTAAAGCAG
GCCTGCACCCCCATGTTCCGGGAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGGCCATG
GCAGATGCCCTGCTAGAGCGAGGCTACTCACTGGTATCAGGTGGTACTGACAACCACCTG
GTGCTGGTGGACCTGCGGCCCAAGGGCCTGGATGGAGCTCGGGCTGAGCGGGTGCTAGAG
CTTGTATCCATCACTGCCAACAAGAACACCTGTCCTGGAGACCGAAGTGCCATCACACCG
GGCGGCCTGCGGCTTGGGGCCCCAGCCTTAACTTCTCGACAGTTCCGTGAGGATGACTTC
CGGAGAGTTGTGGACTTTATAGATGAAGGGGTCAACATTGGCTTAGAGGTGAAGAGCAAG
ACTGCCAAGCTCCAGGATTTCAAATCCTTCCTGCTTAAGGACTCAGAAACAAGTCAGCGT
CTGGCCAACCTCAGGCAACGGGTGGAGCAGTTTGCCAGGGCCTTCCCCATGCCTGGTTTT
GATGAGCATTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U23143

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_3_Locus:
12q12-q14

# Metabolic_Enzyme_3_SNPs:
rs2229717; rs2229718; rs2229716; rs11615783; rs28365862; rs28365863; rs7301155; rs12319666; rs11557165; rs11557163; rs11557167; rs11557162; rs14201; rs2229715; rs11557166; rs10603176; rs28365864; rs34095989; rs34808817; rs35850385; rs35467141; rs12826178; rs10717122; rs35603162; rs10783815; rs11609986; rs11612037; rs11612551; rs11829843; rs3204635; rs35132254; rs6581130; rs7134826; rs7485577

# Metabolic_Enzyme_3_General_References:
8999870; 8505317; 10828359

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5961

# Metabolic_Enzyme_4_Name:
Aminomethyltransferase, mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
Glycine cleavage system T protein; GCVT

# Metabolic_Enzyme_4_Gene_Name:
AMT

# Metabolic_Enzyme_4_Protein_Sequence:
>Aminomethyltransferase, mitochondrial precursor
MQRAVSVVARLGFRLQAFPPALCRPLSCAQEVLRRTPLYDFHLAHGGKMVAFAGWSLPVQ
YRDSHTDSHLHTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFT
NEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDNALL
ALQGPTAAQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPVAGA
VHLATAILKNPEVKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAM
DFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPILNMEGTKIGTVTSGCPSPSLKKNV
AMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLK

# Metabolic_Enzyme_4_Number_of_Residues:
403

# Metabolic_Enzyme_4_Molecular_Weight:
43947

# Metabolic_Enzyme_4_Theoretical_pI:
8.69

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  aminomethyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
Process:  glycine catabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_4_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
The glycine cleavage system catalyzes the degradation of glycine

# Metabolic_Enzyme_4_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00670  One carbon pool by folate;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_4_Reaction:
protein-S-aminomethyldihydrolipoyllysine + tetrahydrofolate = protein-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01571:GCV_T;
PF08669:GCV_T_C

# Metabolic_Enzyme_4_Signals:
1-23

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.1.2.10

# Metabolic_Enzyme_4_GenBank_ID_Protein:
391721

# Metabolic_Enzyme_4_SwissProt_ID:
GCST_HUMAN (P48728)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
AMT

# Metabolic_Enzyme_4_Geneatlas_id:
AMT

# Metabolic_Enzyme_4_hgnc_id:
HGNC:473

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_4_Gene_Sequence:
>1212 bp
ATGCAGAGGGCTGTAAGTGTGGTGGCCCGTCTGGGCTTTCGCCTGCAGGCATTCCCCCCG
GCCTTGTGTCGTCCACTTAGTTGCGCACAGGAGGTGCTCCGCAGGACACCGCTCTATGAC
TTCCACCTGGCCCACGGCGGGAAAATGGTGGCGTTTGCGGGTTGGAGTCTGCCAGTGCAG
TACCGGGACAGTCACACTGACTCGCACCTGCACACACGCCAGCACTGCTCGCTCTTTGAC
GTGTCTCATATGCTGCAGACCAAGATACTTGGTAGTGACCGGGTGAAGCTGATGGAGAGT
CTAGTGGTTGGAGACATTGCAGAGCTAAGACCAAACCAGGGGACACTGTCGCTGTTTACC
AACGAGGCTGGAGGCATCTTAGATGACTTGATTGTAACCAATACTTCTGAGGGCCACCTG
TATGTGGTGTCCAACGCTGGCTGCTGGGAGAAAGATTTGGCCCTCATGCAGGACAAGGTC
AGGGAGCTTCAGAACCAGGGCAGAGATGTGGGCCTGGAGGTGTTGGATAATGCCCTGCTA
GCTCTGCAAGGCCCCACTGCAGCCCAGGTACTACAGGCCGGCGTGGCAGATGACCTGAGG
AAACTGCCCTTCATGACCAGTGCTGTGATGGAGGTGTTTGGCGTGTCTGGCTGCCGCGTG
ACCCGCTGTGGCTACACAGGAGAGGATGGTGTGGAGATCTCGGTGCCGGTAGCGGGGGCA
GTTCACCTGGCAACAGCTATTCTGAAAAACCCAGAGGTGAAGCTGGCAGGGCTGGCAGCC
AGGGACAGCCTGCGCCTGGAGGCAGGCCTCTGCCTGTATGGGAATGACATTGATGAACAC
ACTACACCTGTGGAGGGCAGCCTCAGTTGGACACTGGGGAAGCGCCGCCGAGCTGCTATG
GACTTCCCTGGAGCCAAGGTCATTGTTCCCCAGCTGAAGGGCAGGGTGCAGCGGAGGCGT
GTGGGGTTGATGTGTGAGGGGGCCCCCATGCGGGCACACAGTCCCATCCTGAACATGGAG
GGTACCAAGATTGGTACTGTGACTAGTGGCTGCCCCTCCCCCTCTCTGAAGAAGAATGTG
GCGATGGGTTATGTGCCCTGCGAGTACAGTCGTCCAGGGACAATGCTGCTGGTAGAGGTG
CGGCGGAAGCAGCAGATGGCTGTAGTCAGCAAGATGCCCTTTGTGCCCACAAACTACTAT
ACCCTCAAGTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
D13811

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_4_Locus:
3p21.2-p21.1

# Metabolic_Enzyme_4_SNPs:
rs11715915; rs1464567; rs1464568; rs4855873; rs9859556; rs11922013; rs1041964; rs34568346; rs13095834; rs3049036; rs34457565; rs35024166; rs11425937; rs10640; rs11130192; rs11710609; rs1464566; rs1464569; rs1522929; rs1803637; rs1996874; rs34812788; rs4855874; rs4855877; rs6446272; rs6446273; rs6762593; rs6779432; rs6779524; rs6784820; rs6997; rs8897; rs940045; rs9814873

# Metabolic_Enzyme_4_General_References:
7916605; 8188235; 8005589; 9600239; 9621520; 10873393; 11286506

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
6073

# Metabolic_Enzyme_5_Name:
Sarcosine dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
SarDH; BPR-2

# Metabolic_Enzyme_5_Gene_Name:
SARDH

# Metabolic_Enzyme_5_Protein_Sequence:
>Sarcosine dehydrogenase, mitochondrial precursor
MASLSRALRVAAAHPRQSPTRGMGPCNLSSAAGPTAEKSVPYQRTLKEGQGTSVVAQGPS
RPLPSTANVVVIGGGSLGCQTLYHLAKLGMSGAVLLERERLTSGTTWHTAGLLWQLRPSD
VEVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVESH
VLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTGI
RVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTER
IEGIQNMPNVRDHDASVYLRLQGDALSVGGYEANPIFWEEVSDKFAFGLFDLDWEVFTQH
IEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGC
GQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRERSHESYAKNYSVVFPHDEPLAG
RNMRRDPLHEELLGQGCVFQERHGWERPGWFHPRGPAPVLEYDYYGAYGSRAHEDYAYRR
LLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR
PPGSTVYTCMLNHRGGTESDLTVSRLAPSHQASPLAPAFEGDGYYLAMGGAVAQHNWSHI
TTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQEVLDADLSNEAFPFSTHKLLRAAGH
LVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRAIDSLSIEKGYRHW
HADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVCFTMEDKVPMFGLE
AIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDPSGGPVSLDFVKSGDYALERMGVTYGAQ
AHLKSPFDPNNKRVKGIY

# Metabolic_Enzyme_5_Number_of_Residues:
918

# Metabolic_Enzyme_5_Molecular_Weight:
101038

# Metabolic_Enzyme_5_Theoretical_pI:
7.26

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  aminomethyltransferase activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
Process:  glycine catabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Sarcosine + acceptor + H(2)O = glycine + formaldehyde + reduced acceptor

# Metabolic_Enzyme_5_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_5_Reaction:
sarcosine + acceptor + H2O = glycine + formaldehyde + reduced acceptor

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01266:DAO;
PF01571:GCV_T;
PF08669:GCV_T_C

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.5.99.1

# Metabolic_Enzyme_5_GenBank_ID_Protein:
5902974

# Metabolic_Enzyme_5_SwissProt_ID:
SARDH_HUMAN (Q9UL12)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
SARDH

# Metabolic_Enzyme_5_Geneatlas_id:
SARDH

# Metabolic_Enzyme_5_hgnc_id:
HGNC:10536

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_5_Gene_Sequence:
>2757 bp
ATGGCCTCACTGAGCCGAGCCCTACGTGTGGCTGCTGCCCACCCTCGCCAGAGCCCTACC
CGGGGCATGGGGCCATGCAACCTGTCCAGCGCAGCTGGCCCCACAGCCGAGAAGAGTGTG
CCATATCAGCGGACCCTGAAGGAGGGACAGGGCACCTCGGTGGTGGCCCAAGGCCCAAGC
CGGCCCCTGCCCAGCACGGCCAACGTGGTGGTCATTGGTGGAGGCAGCTTGGGCTGCCAG
ACCCTGTACCACCTGGCCAAGCTGGGCATGAGTGGGGCGGTGCTGCTGGAGCGGGAGCGG
CTGACCTCCGGGACCACCTGGCACACGGCAGGCCTGCTGTGGCAGCTGCGGCCCAGTGAC
GTGGAGGTGGAGCTTCTGGCCCACACTCGGCGGGTGGTGAGCCGGGAGCTGGAGGAGGAG
ACGGGACTACACACGGGCTGGATCCAGAATGGGGGCCTCTTCATCGCGTCCAACCGGCAG
CGCCTGGACGAGTACAAGAGGCTCATGTCGCTGGGCAAGGCGTATGGTGTGGAATCCCAT
GTGCTGAGCCCGGCAGAGACCAAGACTCTGTACCCGCTGATGAATGTGGACGACCTCTAC
GGGACCCTGTATGTGCCGCACGACGGTACCATGGACCCCGCTGGCACCTGTACCACCCTC
GCCAGGGCAGCTTCTGCCCGAGGAGCACAGGTCATTGAGAACTGCCCAGTGACCGGCATT
CGTGTGTGGACGGATGATTTTGGGGTGCGGCGGGTCGCGGGTGTGGAGACTCAGCATGGT
TCCATCCAGACACCCTGCGTGGTCAACTGTGCAGGAGTGTGGGCAAGTGCTGTGGGCCGG
ATGGCTGGAGTCAAGGTCCCGCTGGTGGCCATGCACCATGCCTATGTCGTCACCGAGCGC
ATCGAGGGGATTCAGAACATGCCCAATGTCCGTGATCATGATGCCTCTGTCTACCTCCGC
CTCCAAGGGGATGCCTTGTCTGTGGGTGGCTATGAGGCCAACCCCATCTTTTGGGAGGAG
GTGTCAGACAAGTTTGCCTTCGGCCTCTTTGACCTGGACTGGGAGGTGTTCACCCAGCAC
ATTGAAGGCGCCATCAACAGGGTCCCCGTGCTGGAGAAGACAGGAATCAAGTCCACGGTC
TGCGGCCCTGAATCCTTCACGCCCGACCACAAGCCCCTGATGGGGGAGGCACCTGAGCTC
CGAGGGTTCTTCCTGGGCTGTGGCTTCAACAGCGCAGGAATGATGCTGGGTGGTGGCTGT
GGGCAGGAGCTGGCCCACTGGATCATCCATGGGCGCCCGGAGAAGGACATGCATGGCTAT
GACATCAGGCGCTTCCATCACTCGCTCACGGACCACCCCCGCTGGATCCGAGAGCGAAGC
CATGAGTCCTACGCCAAGAACTACTCCGTCGTCTTCCCCCACGATGAGCCGCTGGCCGGG
CGCAACATGAGGAGAGACCCGCTGCATGAGGAACTCCTTGGACAAGGCTGCGTGTTCCAG
GAGCGGCATGGCTGGGAGCGACCGGGATGGTTTCATCCCCGAGGCCCAGCTCCGGTCCTC
GAGTACGACTACTACGGGGCTTACGGGAGCCGCGCGCACGAGGACTACGCCTACCGCAGG
CTGCTGGCAGACGAGTACACCTTCGCCTTCCCGCCCCACCACGACACGATCAAGAAGGAG
TGCCTGGCCTGCAGAGGGGCCGCCGCTGTGTTTGACATGTCCTACTTCGGGAAGTTCTAC
CTGGTGGGGCTGGATGCAAGGAAGGCTGCCGACTGGCTCTTCTCCGCAGATGTCAGCCGA
CCCCCAGGCTCCACCGTGTACACGTGCATGCTCAACCACCGTGGGGGCACCGAGAGTGAC
CTGACTGTCAGCCGCCTGGCACCCAGCCACCAGGCCTCCCCGCTGGCCCCCGCCTTTGAA
GGGGACGGTTACTACCTGGCCATGGGCGGGGCCGTGGCCCAGCACAACTGGTCCCACATC
ACCACCGTGCTGCAGGACCAGAAGTCCCAGTGCCAGCTCATCGACAGCTCCGAGGACCTG
GGTATGATCAGTATCCAGGGCCCAGCCAGCCGAGCCATTTTGCAGGAGGTGCTGGACGCA
GACCTGAGCAACGAGGCCTTCCCGTTCTCCACCCACAAGCTACTGAGAGCCGCAGGGCAC
CTGGTCCGAGCCATGCGGCTGTCCTTTGTGGGGGAGCTGGGCTGGGAGCTGCACATTCCA
AAGGCGTCCTGCGTGCCTGTGTACCGGGCTGTGATGGCCGCGGGTGCCAAGCACGGCCTC
ATCAACGCAGGGTACCGCGCCATCGACTCCCTGAGCATTGAGAAAGGCTACCGGCACTGG
CACGCGGACCTGCGGCCAGACGACAGCCCCCTGGAGGCAGGCCTGGCCTTCACCTGCAAG
CTCAAGTCGCCGGTGCCCTTCCTGGGGAGGGAGGCCCTGGAGCAGCAGCGGGCCGCAGGC
CTCCGCCGGCGCCTGGTGTGCTTCACCATGGAGGACAAAGTACCCATGTTTGGCCTGGAG
GCCATCTGGAGGAACGGCCAAGTGGTGGGCCATGTCCGGAGGGCTGACTTTGGGTTCGCC
ATCGACAAGACCATCGCCTACGGTTACATCCATGACCCCAGCGGTGGGCCGGTCTCGCTG
GACTTTGTGAAGAGCGGGGACTATGCCCTGGAGAGAATGGGGGTGACCTATGGTGCCCAG
GCTCACCTGAAGTCGCCCTTCGACCCCAACAACAAGAGGGTGAAGGGAATCTACTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AF095735

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_5_Locus:
9q33-q34

# Metabolic_Enzyme_5_SNPs:
rs886016; rs2073817; rs35559818; rs35218200; rs129932; rs2502740; rs573904; rs2073815; rs2519123; rs129886; rs12376409; rs2905214; rs497622; rs493901; rs579236; rs12375833; rs2073906; rs2510263; rs2488553; rs579232; rs756691; rs582326; rs4979633; rs129935; rs1557648; rs2427981; rs2797835; rs129907; rs2427992; rs129889; rs4979630; rs129936; rs10114133; rs2502739; rs129902; rs2502746; rs2427995; rs129892; rs2519120; rs2502741; rs129901; rs2427988; rs7852702; rs2502745; rs2797820; rs916619; rs129895; rs129891; rs129900; rs488013; rs129893; rs2519070; rs2797830; rs694357; rs2510234; rs4744533; rs129894; rs129959; rs2797844; rs2502738; rs2502736; rs3025448; rs129903; rs9409848; rs129934; rs1076149; rs7027605; rs129897; rs916620; rs2427991; rs129952; rs10821519; rs7859013; rs12345624; rs10821578; rs2428103; rs2797836; rs694821; rs2427999; rs2519130; rs2073816; rs2283125; rs3780804; rs12341880; rs129925; rs129940; rs129933; rs2510240; rs733347; rs2027963; rs12341402; rs2797842; rs7857468; rs129890; rs2519072; rs1548362; rs495464; rs129937; rs129957; rs2797837; rs756681; rs2251217; rs3003587; rs129961; rs129960; rs7040170; rs4979631; rs129905; rs129898; rs756687; rs129927; rs7871679; rs756680; rs7849946; rs2797823; rs2502759; rs522676; rs129931; rs2797838; rs2427989; rs7024668; rs2073836; rs10821518; rs2519126; rs2427990; rs756682; rs129899; rs2797834; rs875152; rs129904; rs2427985; rs756690; rs2797831; rs129939; rs2519122; rs2519129; rs129942; rs4979627; rs9409879; rs2797829; rs129955; rs7034045; rs9409843; rs2797839; rs3025452; rs2427994; rs3025444; rs3780803; rs2797821; rs129924; rs2502747; rs1548363; rs10993768; rs10121428; rs2797843; rs2519121; rs129929; rs2427978; rs2797845; rs129941; rs7854480; rs129946; rs2797828; rs2502757; rs2519124; rs129926; rs2519119; rs2027962; rs12685740; rs688511; rs129896; rs489851; rs4744534; rs593824; rs17150844; rs525412; rs129921; rs12685900; rs10993960; rs2502734; rs129953; rs12004083; rs129944; rs2510235; rs129949; rs7043939; rs2073834; rs129906; rs7870095; rs129945; rs511293; rs2427979; rs2510247; rs12345442; rs675713; rs129948; rs2510248; rs2073835; rs2797841; rs7852531; rs2519071; rs9409877; rs129954; rs2427993; rs10993771; rs129922; rs10821521; rs2427984; rs7033395; rs733149; rs9409819; rs12006070; rs9775360; rs10993767; rs129930; rs12554854; rs9409818; rs2502742; rs2254109; rs129956; rs522673; rs129951; rs10993775; rs7857062; rs10993778; rs129950; rs2510245; rs12686773; rs129887; rs4979632; rs9409849; rs730007; rs3024257; rs3824568; rs10821520; rs2797840; rs13285775; rs3780802; rs13285421; rs10993772; rs9409878; rs10993962; rs129885; rs129928; rs129888; rs10465165; rs3025439; rs35699831; rs35664470; rs3202417; rs35013479; rs34100523; rs35457000; rs9409852; rs667021; rs2488554; rs10993782; rs10113974; rs9409853; rs10124430; rs10993781; rs1808179; rs35126944; rs10124431; rs35399459; rs2073907; rs7861063; rs5901025; rs2428102; rs491072; rs2502761; rs476835; rs492847; rs2318818; rs2073908; rs12237736; rs3081200; rs11381123; rs2797846; rs35684137; rs33964182; rs7034592; rs2283126; rs2427986; rs10993952; rs35494753; rs35262528; rs2502758; rs34679750; rs34478209; rs34194155; rs35687618; rs34907787; rs484918; rs2519125; rs28380271; rs35957773; rs34896305; rs33917417; rs10624400; rs13296909; rs35597342; rs3216303; rs611111; rs2520001; rs10993776; rs2519117; rs10993956; rs35425856; rs2849750; rs34124624; rs537067; rs7048777; rs2488550; rs2427982; rs4979628; rs3025447; rs28526121; rs34566194; rs129958; rs35683139; rs28754398; rs9409881; rs2797832; rs34206794; rs34271750; rs4273911; rs10993953; rs2427987; rs7034604; rs35434683; rs11507041; rs35514590; rs2427996; rs9409842; rs34318361; rs7856598; rs28503516; rs28395318; rs12235666; rs12683167; rs3025443; rs36078306; rs28610198; rs2427983; rs10993773; rs28597727; rs35718689; rs10993957; rs13300407; rs34594765; rs13284697; rs35594550; rs35483234; rs7024662; rs11999718; rs13300417; rs10116161; rs35041821; rs7039668; rs7848155; rs13283881; rs35581742; rs34409064; rs10993769; rs12236251; rs34863344; rs13283888; rs10993766; rs34508494; rs9409821; rs10993780; rs28799017; rs10993770; rs5901026; rs10117852; rs3216874; rs7044103; rs28718366; rs28645102; rs9409841; rs2519131; rs509657; rs34951518; rs3025451; rs10993954; rs2427997; rs10121093; rs2427998; rs10993777; rs35012497; rs12342230; rs2502744; rs35054983; rs35259398; rs34217138; rs2519127; rs10117985; rs13296075; rs34725672; rs11999717; rs35905090; rs34835500; rs35550754; rs35884475; rs4059245; rs13286586; rs10993765; rs3025446; rs28378751; rs10647611; rs10993951; rs35272329; rs36121816; rs28558118; rs28568403; rs10993958; rs2797833; rs35464627; rs3081171; rs13296710; rs129938; rs34531646; rs34643555; rs34758056; rs28561635; rs35412066; rs3025449; rs34229981; rs2502735; rs12339007; rs10993955; rs33910296; rs35507421; rs7044072; rs2502743; rs34244579; rs2502737; rs682392; rs35211200; rs12350635; rs35085391; rs2427980; rs36003213; rs35160465; rs28604501; rs10671837; rs3025450; rs9409845; rs28549806; rs3025445; rs1981510; rs669730; rs129923; rs10993779; rs2797822; rs28498131; rs28472298; rs34168307; rs11438150; rs34984303; rs35659629; rs34500732; rs34286734; rs129943; rs35245986; rs35138178; rs34619717; rs3025441; rs34763434; rs3025440; rs3025438; rs10718001; rs3758346; rs10465166; rs3025437; rs35843704; rs3025442; rs9409840; rs35234867; rs10993948; rs10993949; rs10993950; rs129882; rs129883; rs129884; rs129914; rs129915; rs129916; rs129917; rs129918; rs129919; rs2073833; rs2073837; rs2097628; rs3025414; rs3025415; rs3025416; rs3025417; rs3025418; rs3025419; rs3025421; rs3025422; rs3025423; rs3025424; rs3025425; rs3025431; rs3025432; rs3025433; rs3025434; rs3025435; rs3025436; rs6271; rs646708; rs732833; rs7851898; rs7859358; rs9409875

# Metabolic_Enzyme_5_General_References:
10444331; 10686491

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5246

# Metabolic_Enzyme_6_Name:
5-aminolevulinate synthase, erythroid-specific, mitochondrial precursor

# Metabolic_Enzyme_6_Synonyms:
5-aminolevulinic acid synthase; Delta- aminolevulinate synthase; Delta-ALA synthetase; ALAS-E

# Metabolic_Enzyme_6_Gene_Name:
ALAS2

# Metabolic_Enzyme_6_Protein_Sequence:
>5aminolevulinate synthase, erythroidspecific, mitochondrial precursor
MVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIGRCPILATQGPNCSQIHLKATKAGG
DSPSWAKGHCPFMLSELQDGKSKIVQKAAPEVQEDVKAFKTDLPSSLVSVSLRKPFSGPQ
EQEQISGKVTHLIQNNMPGNYVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQH
FSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELE
QELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKF
VFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVH
AVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFT
TSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRV
GNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAW
TAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA

# Metabolic_Enzyme_6_Number_of_Residues:
587

# Metabolic_Enzyme_6_Molecular_Weight:
64634

# Metabolic_Enzyme_6_Theoretical_pI:
8.19

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  transferase activity, transferring nitrogenous groups
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
Function:  N-acyltransferase activity
Function:  N-succinyltransferase activity
Function:  5-aminolevulinate synthase activity
 ||
>>>
Process:  biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  heterocycle metabolism
Process:  porphyrin metabolism
Process:  porphyrin biosynthesis
Process:  heme biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2)

# Metabolic_Enzyme_6_Pathway:
map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_6_Reaction:
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00155:Aminotran_1_2;
PF09029:Preseq_ALAS

# Metabolic_Enzyme_6_Signals:
1-15

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.3.1.37

# Metabolic_Enzyme_6_GenBank_ID_Protein:
28586

# Metabolic_Enzyme_6_SwissProt_ID:
HEM0_HUMAN (P22557)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ALAS2

# Metabolic_Enzyme_6_Geneatlas_id:
ALAS2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:397

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_6_Gene_Sequence:
>1749 bp
ATGCTGCTACAGTGCTGCCCAGTGCTTGCCCGGGGCCCCACAAGCCTCCTAGGCAAGGTG
GTTAAGACTCACCAGTTCCTGTTTGGTATTGGACGCTGTCCCATCCTGGCTACCCAAGGA
CCAAACTGTTCTCAAATCCACCTTAAGGCAACAAAGGCTGGAGGAGATTCTCCATCTTGG
GCGAAGGGCCACTGTCCCTTCATGCTGTCGGAACTCCAGGATGGGAAGAGCAAGATTGTG
CAGAAGGCAGCCCCAGAAGTCCAGGAAGATGTGAAGGCTTTCAAGACAGATCTGCCTAGC
TCCCTGGTCTCAGTCAGCCTAAGGAAGCCATTTTCCGGTCCCCAGGAGCAGGAGCAGATC
TCTGGGAAGGTCACACACCTGATTCAGAACAATATGCCTGGAAACTATGTCTTCAGTTAT
GACCAGTTTTTCAGGGACAAGATCATGGAGAAGAAACAGGATCACACCTACCGTGTGTTC
AAGACTGTGAACCGCTGGGCTGATGCATATCCCTTTGCCCAACATTTCTTTGAGGCATCT
GTGGCCTCAAAGGATGTGTCCGTCTGGTGTAGTAATGATTACCTGGGCATGAGCCGACAC
CCTCAGGTCTTGCAAGCCACACAGGAGACCCTGCAGCGTCATGGTGCTGGAGCTGGTGGC
ACCCGCAACATCTCAGGCACCAGTAAGTTTCATGTGGAGCTTGAGCAGGAGCTGGCTGAG
CTGCACCAGAAGGACTCAGCCCTGCTCTTCTCCTCCTGCTTTGTTGCCAATGACTCTACT
CTCTTCACCTTGGCCAAGATCCTGCCAGGGTGCGAGATTTACTCAGACGCAGGCAACCAT
GCTTCCATGATCCAAGGTATCCGTAACAGTGGAGCAGCCAAGTTTGTCTTCAGGCACAAT
GACCCTGACCACCTAAAGAAACTTCTAGAGAAGTCTAACCCTAAGATACCCAAAATTGTG
GCCTTTGAGACTGTCCACTCCATGGATGGTGCCATCTGTCCCCTCGAGGAGTTGTGTGAT
GTGTCCCACCAGTATGGGGCCCTGACCTTCGTGGATGAGGTCCATGCTGTAGGACTGTAT
GGGTCCCGGGGCGCTGGGATTGGGGAGCGTGATGGAATTATGCATAAGATTGACATCATC
TCTGGAACTCTTGGCAAGGCCTTTGGCTGTGTGGGCGGCTACATTGCCAGCACCCGTGAC
TTGGTGGACATGGTGCGCTCCTATGCTGCAGGCTTCATCTTTACCACTTCTCTGCCCCCC
ATGGTGCTCTCTGGAGCTCTAGAATCTGTGCGGCTGCTCAAGGGAGAGGAGGGCCAAGCC
CTGAGGCGAGCCCACCAGCGCAATGTCAAGCACATGCGCCAGCTACTCATGGACAGGGGC
CTTCCTGTCATCCCCTGCCCCAGCCACATCATCCCCATCCGGGTGGGCAATGCAGCACTC
AACAGCAAGCTCTGTGATCTCCTGCTCTCCAAGCATGGCATCTATGTGCAGGCCATCAAC
TACCCAACTGTCCCCCGGGGTGAAGAGCTCCTGCGCTTGGCACCCTCCCCCCACCACAGC
CCTCAGATGATGGAAGATTTTGTGGAGAAGCTGCTGCTGGCTTGGACTGCGGTGGGGCTG
CCCCTCCAGGATGTGTCTGTGGCTGCCTGCAATTTCTGTCGCCGTCCTGTACACTTTGAG
CTCATGAGTGAGTGGGAACGTTCCTACTTCGGGAACATGGGGCCCCAGTATGTCACCACC
TATGCCTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
X56352

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_6_Locus:
Xp11.21

# Metabolic_Enzyme_6_SNPs:
rs6612251; rs6612250; rs983823; rs727468; rs7881427; rs1476012; rs12011419; rs17002406; rs6612254; rs28382698; rs727467; rs4826366; rs17250674; rs12008515; rs6612253; rs7058892; rs2735373; rs2283678; rs704145; rs5960385; rs17855549; rs28935484; rs35075981; rs12844681; rs3179589; rs5913786; rs12847773; rs983824; rs3175205; rs12397173; rs5914245; rs2735371; rs34607792; rs11442907; rs34047691; rs2742930; rs1022428; rs35190529; rs6612252; rs35010513; rs1012857; rs12844061; rs1016042; rs2213516; rs12850077; rs35068062; rs2742932; rs2858762; rs35939396; rs35101681; rs12850081; rs41308048; rs10524398; rs12837319; rs2735372; rs2858763; rs34102482; rs972636; rs1008681; rs10126694; rs11541054; rs1180024; rs1494366; rs1883158; rs2301416; rs2301417; rs2742928; rs2858764; rs2858765; rs3180303; rs3180304; rs6651872; rs7889977; rs7891167; rs974612

# Metabolic_Enzyme_6_General_References:
2263504; 2050125; 9642238; 8107717; 1570328; 9858242; 10577279; 10029606

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5251

# Metabolic_Enzyme_7_Name:
5-aminolevulinate synthase, nonspecific, mitochondrial precursor

# Metabolic_Enzyme_7_Synonyms:
5-aminolevulinic acid synthase; Delta-aminolevulinate synthase; Delta-ALA synthetase; ALAS-H

# Metabolic_Enzyme_7_Gene_Name:
ALAS1

# Metabolic_Enzyme_7_Protein_Sequence:
>5aminolevulinate synthase, nonspecific, mitochondrial precursor
MESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALSTAAVHYQQIKE
TPPASEKDKTAKAKVQQTPDGSQQSPDGTQLPSGHPLPATSQGTASKCPFLAAQMNQRGS
SVFCKASLELQEDVQEMNAVRKEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQRPE
RVSHLLQDNLPKSVSTFQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSLI
TKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADL
HGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHND
VSHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLYG
ARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPM
LLAGALESVRILKSAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAKN
TEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQVGLE
LKPHSSAECNFCRRPLHFEVMSEREKSYFSGLSKLVSAQA

# Metabolic_Enzyme_7_Number_of_Residues:
640

# Metabolic_Enzyme_7_Molecular_Weight:
70582

# Metabolic_Enzyme_7_Theoretical_pI:
8.57

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  transferase activity, transferring nitrogenous groups
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
Function:  N-acyltransferase activity
Function:  N-succinyltransferase activity
Function:  5-aminolevulinate synthase activity
 ||
>>>
Process:  biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  heterocycle metabolism
Process:  porphyrin metabolism
Process:  porphyrin biosynthesis
Process:  heme biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2)

# Metabolic_Enzyme_7_Pathway:
map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_7_Reaction:
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.3.1.37

# Metabolic_Enzyme_7_GenBank_ID_Protein:
28583

# Metabolic_Enzyme_7_SwissProt_ID:
HEM1_HUMAN (P13196)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
ALAS1

# Metabolic_Enzyme_7_Geneatlas_id:
ALAS1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:396

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_7_Gene_Sequence:
>1923 bp
ATGGAGAGTGTTGTTCGCCGCTGCCCATTCTTATCCCGAGTCCCCCAGGCCTTTCTGCAG
AAAGCAGGCAAATCTCTGTTGTTCTATGCCCAAAACTGCCCCAAGATGATGGAAGTTGGG
GCCAAGCCAGCCCCTCGGGCATTGTCCACTGCAGCAGTACACTACCAACAGATCAAAGAA
ACCCCTCCGGCCAGTGAGAAAGACAAAACTGCTAAGGCCAAGGTCCAACAGACTCCTGAT
GGATCCCAGCAGAGTCCAGATGGCACACAGCTTCCGTCTGGACACCCCTTGCCTGCCACA
AGCCAGGGCACTGCAAGCAAATGCCCTTTCCTGGCAGCACAGATGAATCAGAGAGGCAGC
AGTGTCTTCTGCAAAGCCAGTCTTGAGCTTCAGGAGGATGTGCAGGAAATGAATGCCGTG
AGGAAAGAGGTTGCTGAAACCTCAGCAGGCCCCAGTGTGGTTAGTGTGAAAACCGATGGA
GGGGATCCCAGTGGACTGCTGAAGAACTTCCAGGACATTATGCAAAAGCAAAGACCAGAA
AGAGTGTCTCATCTTCTTCAAGATAACTTGCCAAAATCTGTTTCCACTTTTCAGTATGAT
CGTTTCTTTGAGAAAAAAATTGATGAGAAAAAGAATGACCACACCTATCGAGTTTTTAAA
ACTGTGAACCGGCGAGCACACATCTTCCCCATGGCAGATGACTATTCAGACTCCCTCATC
ACCAAAAAGCAAGTGTCAGTCTGGTGCAGTAATGACTACCTAGGAATGAGTCGCCACCCA
CGGGTGTGTGGGGCAGTTATGGACACTTTGAAACAACATGGTGCTGGGGCAGGTGGTACT
AGAAATATTTCTGGAACTAGTAAATTCCATGTGGACTTAGAGCGGGAGCTGGCAGACCTC
CATGGGAAAGATGCCGCACTCTTGTTTTCCTCGTGCTTTGTGGCCAATGACTCAACCCTC
TTCACCCTGGCTAAGATGATGCCAGGCTGTGAGATTTACTCTGATTCTGGGAACCATGCC
TCCATGATCCAAGGGATTCGAAACAGCCGAGTGCCAAAGTACATCTTCCGCCACAATGAT
GTCAGCCACCTCAGAGAACTGCTGCAAAGATCTGACCCCTCAGTCCCCAAGATTGTGGCA
TTTGAAACTGTCCATTCAATGGATGGGGCGGTGTGCCCACTGGAAGAGCTGTGTGATGTG
GCCCATGAGTTTGGAGCAATCACCTTCGTGGATGAGGTCCACGCAGTGGGGCTTTATGGG
GCTCGAGGCGGAGGGATTGGGGATCGGGATGGAGTCATGCCAAAAATGGACATCATTTCT
GGAACACTTGGCAAAGCCTTTGGTTGTGTTGGAGGGTACATCGCCAGCACGAGTTCTCTG
ATTGACACCGTACGGTCCTATGCTGCTGGCTTCATCTTCACCACCTCTCTGCCACCCATG
CTGCTGGCTGGAGCCCTGGAGTCTGTGCGGATCCTGAAGAGCGCTGAGGGACGGGTGCTT
CGCCGCCAGCACCAGCGCAACGTCAAACTCATGAGACAGATGCTAATGGATGCCGGCCTC
CCTGTTGTCCACTGCCCCAGCCACATCATCCCTGTGCGGGTTGCAGATGCTGCTAAAAAC
ACAGAAGTCTGTGATGAACTAATGAGCAGACATAACATCTACGTGCAAGCAATCAATTAC
CCTACGGTGCCCCGGGGAGAAGAGCTCCTACGGATTGCCCCCACCCCTCACCACACACCC
CAGATGATGAACTACTTCCTTGAGAATCTGCTAGTCACATGGAAGCAAGTGGGGCTGGAA
CTGAAGCCTCATTCCTCAGCTGAGTGCAACTTCTGCAGGAGGCCACTGCATTTTGAAGTG
ATGAGTGAAAGAGAGAAGTCCTATTTCTCAGGCTTGAGCAAGTTGGTATCTGCTCAGGCC
TGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
X56351

# Metabolic_Enzyme_7_Chromosome_Location:
Not Available

# Metabolic_Enzyme_7_Locus:
Not Available

# Metabolic_Enzyme_7_SNPs:
Not Available

# Metabolic_Enzyme_7_General_References:
2263504; 3671094

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5566

# Metabolic_Enzyme_8_Name:
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase

# Metabolic_Enzyme_8_Synonyms:
GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase; Phosphoribosylformylglycinamidine cyclo-ligase; AIRS; Phosphoribosyl-aminoimidazole synthetase; AIR synthase; Phosphoribosylglycinamide formyltransferase; GART; GAR transformylase; 5'-phosphoribosylglycinamide transformylase]

# Metabolic_Enzyme_8_Gene_Name:
GART

# Metabolic_Enzyme_8_Protein_Sequence:
>Trifunctional purine biosynthetic protein adenosine3 Includes: Phosphoribosylamineglycine ligase
MAARVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEKISNTAISISDHTALAQ
FCKEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGPTAEAAQLESSKRFAKEFMDRHGIP
TAQWKAFTKPEEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAF
GAAGETIVIEELLDGEEVSCLCFTDGKTVAPMPPAQDHKRLLEGDGGPNTGGMGAYCPAP
QVSNDLLLKIKDTVLQRTVDGMQQEGTPYTGILYAGIMLTKNGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTLDGLLCTSLPVWLENHTALTVVMASKGYPGDYTKGVEITGFPEA
QALGLEVFHAGTALKNGKVVTHGGRVLAVTAIRENLISALEEAKKGLAAIKFEGAIYRKD
VGFRAIAFLQQPRSLTYKESGVDIAAGNMLVKKIQPLAKATSRSGCKVDLGGFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQLCNKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLSVTEAVVAGIAKACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
HLERITEGDVVVGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTR
IYSHSLLPVLRSGHVKAFAHITGGGLLENIPRVLPEKLGVDLDAQTWRIPRVFSWLQQEG
HLSEEEMARTFNCGVGAVLVVSKEQTEQILRDIQQHKEEAWVIGSVVARAEGSPRVKVKN
LIESMQINGSVLKNGSLTNHFSFEKKKARVAVLISGTGSNLQALIDSTREPNSSAQIDIV
ISNKAAVAGLDKAERAGIPTRVINHKLYKNRVEFDSAIDLVLEEFSIDIVCLAGFMRILS
GPFVQKWNGKMLNIHPSLLPSFKGSNAHEQALETGVTVTGCTVHFVAEDVDAGQIILQEA
VPVKRGDTVATLSERVKLAEHKIFPAALQLVASGTVQLGENGKICWVKEE

# Metabolic_Enzyme_8_Number_of_Residues:
1010

# Metabolic_Enzyme_8_Molecular_Weight:
107768

# Metabolic_Enzyme_8_Theoretical_pI:
6.68

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  phosphoribosylglycinamide formyltransferase activity
Function:  cyclo-ligase activity
Function:  phosphoribosylformylglycinamidine cyclo-ligase activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  phosphoribosylamine-glycine ligase activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  glycine hydroxymethyltransferase activity
Function:  hydroxymethyl-, formyl- and related transferase activity
Function:  catalytic activity
 ||
>>>
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
Process:  IMP biosynthesis
Process:  'de novo' IMP biosynthesis
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  purine base metabolism
Process:  purine base biosynthesis
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_8_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + 1-N-(5-phospho-D-ribosyl)glycinamide

# Metabolic_Enzyme_8_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_8_Reaction:
ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00586:AIRS;
PF02769:AIRS_C;
PF00551:Formyl_trans_N;
PF01071:GARS_A;
PF02843:GARS_C;
PF02844:GARS_N

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 6.3.4.13;EC 6.3.3.1;EC

# Metabolic_Enzyme_8_GenBank_ID_Protein:
31642

# Metabolic_Enzyme_8_SwissProt_ID:
PUR2_HUMAN (P22102)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
GART

# Metabolic_Enzyme_8_Geneatlas_id:
GART

# Metabolic_Enzyme_8_hgnc_id:
HGNC:4163

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Not Available

# Metabolic_Enzyme_8_Gene_Sequence:
>3033 bp
ATGGCAGCCCGAGTACTTATAATTGGCAGTGGAGGAAGGGAACATACGCTGGCCTGGAAA
CTTGCACAGTCTCATCATGTCAAACAAGTGTTGGTTGCCCCAGGAAACGCAGGCACTGCC
TGCTCTGAAAAGATTTCAAATACCGCCATCTCAATCAGTGACCACACTGCCCTTGCTCAA
TTCTGCAAAGAGAAGAAAATTGAATTTGTAGTTGTTGGACCAGAAGCACCTCTGGCTGCT
GGGATTGTTGGGAACCTGAGGTCTGCAGGAGTGCAATGCTTTGGCCCAACAGCAGAAGCG
GCTCAGTTAGAGTCCAGCAAAAGGTTTGCCAAAGAGTTTATGGACAGACATGGAATCCCA
ACCGCACAATGGAAGGCTTTCACCAAACCTGAAGAAGCCTGCAGCTTCATTTTGAGTGCA
GACTTCCCTGCTTTGGTTGTGAAGGCCAGTGGTCTTGCAGCTGGAAAAGGGGTGATTGTT
GCAAAGAGCAAAGAAGAGGCCTGCAAAGCTGTACAAGAGATCATGCAGGAGAAAGCCTTT
GGGGCAGCTGGAGAAACAATTGTCATTGAAGAACTTCTTGACGGAGAAGAGGTGTCGTGT
CTGTGTTTCACTGATGGCAAGACTGTGGCCCCCATGCCCCCAGCACAGGACCATAAGCGA
TTACTGGAGGGAGATGGTGGCCCTAACACAGGGGGAATGGGAGCCTATTGTCCAGCCCCT
CAGGTTTCTAATGATCTATTACTAAAAATTAAAGATACTGTTCTTCAGAGGACAGTGGAT
GGCATGCAGCAAGAGGGTACTCCATATACAGGTATTCTCTATGCTGGAATAATGCTGACC
AAGAATGGCCCAAAAGTTCTAGAGTTTAATTGCCGTTTTGGTGATCCAGAGTGCCAAGTA
ATCCTCCCACTTCTTAAAAGTGATCTTTATGAAGTGATTCAGTCCACCTTAGATGGACTG
CTCTGCACATCTCTGCCTGTTTGGCTAGAAAACCACACCGCCCTAACTGTTGTCATGGCA
AGTAAAGGTTATCCTGGAGACTACACCAAGGGTGTAGAGATAACAGGGTTTCCTGAGGCT
CAAGCTCTAGGACTGGAGGTGTTCCATGCAGGCACTGCCCTCAAAAATGGCAAAGTAGTA
ACTCATGGGGGTAGAGTTCTTGCAGTCACAGCCATCCGGGAAAATCTCATATCAGCCCTT
GAGGAAGCCAAGAAAGGACTAGCTGCTATAAAGTTTGAGGGAGCAATTTATAGGAAAGAC
GTCGGCTTTCGTGCCATAGCTTTCCTCCAGCAGCCCAGGAGTTTGACTTACAAGGAATCT
GGAGTAGATATCGCAGCTGGAAATATGCTGGTCAAGAAAATTCAGCCTTTAGCAAAAGCC
ACTTCCAGATCAGGCTGTAAAGTTGATCTTGGAGGTTTTGCTGGTCTTTTTGATTTAAAA
GCAGCTGGTTTCAAAGATCCCCTTCTGGCCTCTGGAACAGATGGCGTTGGAACTAAACTA
AAGATTGCCCAGCTATGCAATAAACATGATACCATTGGTCAAGATTTGGTAGCAATGTGT
GTTAATGATATTCTGGCACAAGGAGCAGAGCCCCTCTTCTTCCTTGATTACTTTTCCTGT
GGAAAACTTGACCTCAGTGTAACTGAAGCTGTTGTTGCTGGAATTGCTAAAGCTTGTGGA
AAAGCTGGATGTGCTCTCCTTGGAGGTGAAACAGCAGAAATGCCTGACATGTATCCCCCT
GGAGAGTATGACCTAGCTGGGTTTGCCGTTGGTGCCATGGAGCGAGATCAGAAACTCCCT
CACCTGGAAAGAATCACTGAGGGTGATGTTGTTGTTGGAATAGCTTCATCTGGTCTTCAT
AGCAATGGATTTAGCCTTGTGAGGAAAATCGTTGCAAAATCTTCCCTCCAGTACTCCTCT
CCAGCACCTGATGGTTGTGGTGACCAGACTTTAGGGGACTTACTTCTCACGCCTACCAGA
ATCTACAGCCATTCACTGTTACCTGTCCTACGTTCAGGACATGTCAAAGCCTTTGCCCAT
ATTACTGGTGGAGGATTACTAGAGAACATCCCCAGAGTCCTCCCTGAGAAACTTGGGGTA
GATTTAGATGCCCAGACCTGGAGGATCCCCAGGGTTTTCTCATGGTTGCAGCAGGAAGGA
CACCTCTCTGAGGAAGAGATGGCCAGAACATTTAACTGTGGGGTTGGCGCTGTCCTTGTG
GTATCAAAGGAGCAGACAGAGCAGATTCTGAGGGATATCCAGCAGCACAAGGAAGAAGCC
TGGGTGATTGGCAGTGTGGTTGCACGAGCTGAAGGTTCCCCACGTGTGAAAGTCAAGAAT
CTGATTGAAAGCATGCAAATAAATGGGTCAGTGTTGAAGAATGGCTCCCTGACAAATCAT
TTCTCTTTTGAAAAAAAAAAGGCCAGAGTGGCTGTCTTAATATCTGGAACAGGATCGAAC
CTGCAAGCACTTATAGACAGTACTCGGGAACCAAATAGCTCTGCACAAATTGATATTGTT
ATCTCCAACAAAGCCGCAGTAGCTGGGTTAGATAAAGCGGAAAGAGCTGGTATTCCCACT
AGAGTAATTAATCATAAACTGTATAAAAATCGTGTAGAATTTGACAGTGCAATTGACCTA
GTCCTTGAAGAGTTCTCCATAGACATAGTCTGTCTTGCAGGATTCATGAGAATTCTTTCT
GGCCCCTTTGTCCAAAAGTGGAATGGAAAAATGCTCAATATCCACCCATCCTTGCTCCCT
TCTTTTAAGGGTTCAAATGCCCATGAGCAAGCCCTGGAAACCGGAGTCACAGTTACTGGG
TGCACTGTACACTTTGTAGCTGAAGATGTGGATGCTGGACAGATTATTTTGCAAGAAGCT
GTTCCCGTGAAGAGGGGTGATACTGTCGCAACTCTTTCTGAAAGAGTAAAATTAGCAGAA
CATAAAATATTTCCTGCAGCCCTTCAGCTGGTGGCCAGTGGAACTGTACAGCTTGGAGAA
AATGGCAAGATCTGTTGGGTTAAAGAGGAATGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X54199

# Metabolic_Enzyme_8_Chromosome_Location:
Not Available

# Metabolic_Enzyme_8_Locus:
Not Available

# Metabolic_Enzyme_8_SNPs:
rs8971; rs35927582; rs9984077; rs34588874; rs3088267; rs1804385; rs2834235; rs2154583; rs2007053; rs6517177; rs2834234; rs2409495; rs2834231; rs7277056; rs4817579; rs7281488; rs2070390; rs2834233; rs6517178; rs2834232; rs12626309; rs7277370; rs2070388; rs2027592; rs11701506; rs2300374; rs3787708; rs12482067; rs4817577; rs7276309; rs7283354; rs8133555; rs7281539; rs35035222; rs2898199; rs9977204; rs2409496; rs9636610; rs1804387; rs9979696; rs1051053; rs36047950; rs34119195; rs35611348; rs35202323; rs1023353; rs11308370; rs34249284; rs11321647; rs34735620; rs7278664; rs13047636; rs11911652; rs34381057; rs34586050; rs11318804; rs35705698; rs7277653; rs35972629; rs35587841; rs34781902; rs35241940; rs6517176; rs35083461; rs35893472; rs3057407; rs13050812; rs12627522; rs10600803; rs13052087; rs11268409; rs13052247; rs5843612; rs35859824; rs13050476; rs11356836; rs1023147; rs4817578; rs7275193; rs5843610; rs35623101; rs3787707; rs5843611; rs13051452; rs28718282; rs9983042; rs11318765; rs8126979; rs4816460; rs11406208; rs11350074; rs2007041; rs35462886; rs11701911; rs3057404; rs36203279; rs10572084; rs7278081; rs34282313; rs11911134; rs13049658; rs2070387; rs34063527; rs4817580; rs7279549; rs7283126; rs915562; rs9976586

# Metabolic_Enzyme_8_General_References:
2147474; 9224613; 2183217

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5354

# Metabolic_Enzyme_9_Name:
Peroxisomal sarcosine oxidase

# Metabolic_Enzyme_9_Synonyms:
PSO; L-pipecolate oxidase; L-pipecolic acid oxidase

# Metabolic_Enzyme_9_Gene_Name:
PIPOX

# Metabolic_Enzyme_9_Protein_Sequence:
>Peroxisomal sarcosine oxidase
MAAQKDLWDAIVIGAGIQGCFTAYHLAKHRKRILLLEQFFLPHSRGSSHGQSRIIRKAYL
EDFYTRMMHECYQIWAQLEHEAGTQLHRQTGLLLLGMKENQELKTIQANLSRQRVEHQCL
SSEELKQRFPNIRLPRGEVGLLDNSGGVIYAYKALRALQDAIRQLGGIVRDGEKVVEINP
GLLVTVKTTSRSYQAKSLVITAGPWTNQLLRPLGIEMPLQTLRINVCYWREMVPGSYGVS
QAFPCFLWLGLCPHHIYGLPTGEYPGLMKVSYHHGNHADPEERDCPTARTDIGDVQILSS
FVRDHLPDLKPEPAVIESCMYTNTPDEQFILDRHPKYDNIVIGAGFSGHGFKLAPVVGKI
LYELSMKLTPSYDLAPFRISRFPSLGKAHL

# Metabolic_Enzyme_9_Number_of_Residues:
390

# Metabolic_Enzyme_9_Molecular_Weight:
44067

# Metabolic_Enzyme_9_Theoretical_pI:
8.54

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor
Function:  sarcosine oxidase activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  aromatic compound metabolism
Process:  folic acid and derivative metabolism
Process:  tetrahydrofolate metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
Metabolizes sarcosine, L-pipecolic acid and L-proline

# Metabolic_Enzyme_9_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_9_Reaction:
L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF01266:DAO

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
7-26

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 1.5.3.1;EC 1.5.3.7

# Metabolic_Enzyme_9_GenBank_ID_Protein:
7157903

# Metabolic_Enzyme_9_SwissProt_ID:
SOX_HUMAN (Q9P0Z9)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
PIPOX

# Metabolic_Enzyme_9_Geneatlas_id:
PIPOX

# Metabolic_Enzyme_9_hgnc_id:
HGNC:17804

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_9_Gene_Sequence:
>1173 bp
ATGGCGGCTCAGAAAGATCTCTGGGACGCCATTGTGATTGGGGCGGGGATCCAGGGCTGC
TTCACTGCATACCACCTCGCCAAACACAGGAAGAGGATCCTCCTGCTGGAGCAGTTCTTT
CTACCACACTCCCGAGGAAGCTCCCATGGACAAAGCCGGATAATCCGAAAGGCGTACCTG
GAAGACTTTTACACCCGGATGATGCATGAGTGCTATCAGATATGGGCCCAGCTGGAGCAC
GAGGCTGGAACCCAATTGCACAGGCAGACTGGATTACTGCTGCTGGGAATGAAAGAGAAT
CAAGAATTAAAGACAATCCAGGCCAATCTGTCGAGGCAGAGGGTAGAACACCAGTGTCTT
TCATCTGAGGAACTGAAGCAACGTTTCCCAAATATTCGGTTGCCCAGGGGAGAAGTGGGG
CTCTTGGACAATTCCGGAGGAGTTATCTATGCATATAAGGCCCTCAGAGCCCTGCAGGAT
GCAATTCGACAGCTAGGAGGCATAGTGCGTGACGGAGAGAAGGTGGTGGAGATAAACCCA
GGGCTACTGGTCACGGTGAAAACCACCTCCAGGAGCTACCAAGCTAAGAGCTTGGTCATC
ACAGCAGGTCCTTGGACCAACCAGCTCCTCCGTCCCCTGGGCATTGAGATGCCTCTCCAG
ACCCTGCGGATCAACGTGTGTTACTGGCGAGAGATGGTTCCTGGGAGCTATGGTGTGTCC
CAGGCCTTTCCGTGCTTCCTGTGGCTGGGCTTGTGTCCCCACCACATCTACGGACTGCCC
ACAGGAGAGTACCCAGGGCTGATGAAGGTCAGCTATCACCACGGCAACCACGCAGACCCT
GAGGAGCGGGACTGCCCCACAGCACGCACAGACATCGGAGACGTCCAGATCCTGAGCAGC
TTTGTCAGAGATCACTTACCTGATCTGAAGCCCGAGCCTGCTGTCATTGAGAGCTGCATG
TACACGAATACCCCTGATGAGCAGTTCATTCTCGATCGCCACCCAAAGTATGACAACATT
GTCATTGGTGCTGGATTCTCTGGGCACGGGTTCAAGCTGGCCCCTGTGGTGGGGAAGATC
CTGTATGAATTAAGCATGAAATTAACACCATCTTATGACTTGGCACCTTTTCGAATCAGC
CGTTTCCCAAGCCTGGCCAAAGCCCACCTGTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AF134593

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_9_Locus:
17q11.2

# Metabolic_Enzyme_9_SNPs:
rs9890082; rs9912656; rs8081500; rs8067658; rs9908931; rs8067401; rs7211084; rs17795242; rs8077381; rs6505106; rs8066520; rs11869504; rs8078346; rs4795491; rs3736253; rs12325690; rs7225763; rs7217905; rs11868047; rs7211375; rs12326022; rs6505105; rs4794849; rs11869124; rs11869243; rs7213119; rs17852448; rs17856772; rs17856771; rs17856770; rs17852449; rs7223527; rs34642085; rs35277021; rs11291050; rs5819860; rs35037948; rs35675206; rs11424309; rs35805984; rs3884011; rs33913117; rs9899482; rs8074269; rs35121520; rs7224285; rs34991975; rs11404274; rs35812484; rs11652008; rs34431204; rs35429458; rs34830053; rs33927135; rs35145427; rs11386770; rs35719076; rs11653331; rs11655979; rs11869703; rs11869891; rs12150489; rs12936749; rs1319486; rs16964766; rs173248; rs184735; rs189460; rs191562; rs192126; rs193239; rs239268; rs4965971; rs507040; rs507917; rs507949; rs545347; rs546127; rs560156; rs637579; rs7209257; rs7209803; rs7220662; rs7221150; rs8064530; rs8069593; rs8070009; rs8076228; rs8081869; rs8082295; rs9898869; rs9913000

# Metabolic_Enzyme_9_General_References:
10642506; 10931946

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5633

# Metabolic_Enzyme_10_Name:
Alanine--glyoxylate aminotransferase 2, mitochondrial precursor

# Metabolic_Enzyme_10_Synonyms:
(R-3-amino-2-methylpropionate--pyruvate transaminase; AGT 2; Beta-alanine-pyruvate aminotransferase; Beta- ALAAT II; D-AIBAT

# Metabolic_Enzyme_10_Gene_Name:
AGXT2

# Metabolic_Enzyme_10_Protein_Sequence:
>Alanineglyoxylate aminotransferase 2, mitochondrial precursor
MTLIWRHLLRPLCLVTSAPRILEMHPFLSLGTSRTSVTKLSLHTKPRMPPCDFMPERYQS
LGYNRVLEIHKEHLSPVVTAYFQKPLLLHQGHMEWLFDAEGSRYLDFFSGIVTVSVGHCH
PKVNAVAQKQLGRLWHTSTVFFHPPMHEYAEKLAALLPEPLKVIFLVNSGSEANELAMLM
ARAHSNNIDIISFRGAYHGCSPYTLGLTNVGTYKMELPGGTGCQPTMCPDVFRGPWGGSH
CRDSPVQTIRKCSCAPDCCQAKDQYIEQFKDTLSTSVAKSIAGFFAEPIQGVNGVVQYPK
GFLKEAFELVRARGGVCIADEVQTGFGRLGSHFWGFQTHDVLPDIVTMAKGIGNGFPMAA
VITTPEIAKSLAKCLQHFNTFGGNPMACAIGSAVLEVIKEENLQENSQEVGTYMLLKFAK
LRDEFEIVGDVRGKGLMIGIEMVQDKISCRPLPREEVNQIHEDCKHMGLLVGRGSIFSQT
FRIAPSMCITKPEVDFAVEVFRSALTQHMERRAK

# Metabolic_Enzyme_10_Number_of_Residues:
514

# Metabolic_Enzyme_10_Molecular_Weight:
57157

# Metabolic_Enzyme_10_Theoretical_pI:
7.91

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
L-alanine + glyoxylate = pyruvate + glycine

# Metabolic_Enzyme_10_Pathway:
map00252  Alanine and aspartate metabolism;
 map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_10_Reaction:
L-alanine + glyoxylate = pyruvate + glycine

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00202:Aminotran_3

# Metabolic_Enzyme_10_Signals:
1-24

# Metabolic_Enzyme_10_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.6.1.44;EC 2.6.1.40

# Metabolic_Enzyme_10_GenBank_ID_Protein:
12406973

# Metabolic_Enzyme_10_SwissProt_ID:
AGT2_HUMAN (Q9BYV1)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
AGXT2

# Metabolic_Enzyme_10_Geneatlas_id:
AGXT2

# Metabolic_Enzyme_10_hgnc_id:
HGNC:14412

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Mitochondrion (Potential)

# Metabolic_Enzyme_10_Gene_Sequence:
>1545 bp
ATGACTCTAATCTGGAGACATTTGCTGAGACCCTTGTGCCTGGTCACTTCCGCTCCCAGG
ATCCTTGAGATGCATCCTTTCCTGAGCCTAGGTACTTCCCGGACATCAGTAACCAAGCTC
AGTCTTCATACAAAGCCCAGAATGCCTCCATGTGACTTCATGCCTGAAAGATACCAGTCC
CTTGGCTACAACCGTGTCCTGGAAATCCACAAGGAACATCTTTCTCCTGTGGTGACGGCA
TATTTCCAGAAACCCCTGCTGCTCCACCAGGGGCACATGGAGTGGCTCTTTGATGCTGAA
GGAAGCAGATACCTGGATTTCTTTTCCGGGATTGTTACTGTCAGTGTTGGCCATTGCCAC
CCAAAGGTGAATGCAGTGGCACAAAAGCAGCTCGGCCGCCTGTGGCATACAAGCACCGTC
TTCTTCCACCCTCCAATGCATGAATATGCAGAGAAGCTTGCCGCACTTCTTCCTGAGCCT
CTTAAGGTCATTTTCTTGGTGAACAGTGGCTCAGAAGCCAATGAGCTGGCCATGCTGATG
GCCAGGGCGCACTCAAACAACATAGACATCATTTCTTTCAGAGGAGCCTACCATGGATGC
AGTCCTTACACACTTGGCTTGACAAACGTAGGGACCTACAAGATGGAACTCCCTGGTGGG
ACAGGTTGCCAACCAACAATGTGTCCAGATGTTTTTCGTGGCCCTTGGGGAGGAAGCCAC
TGTCGAGATTCTCCAGTGCAAACAATCAGGAAGTGCAGCTGTGCACCAGACTGCTGCCAA
GCTAAAGATCAGTATATTGAGCAATTCAAAGATACGCTGAGCACATCTGTGGCCAAGTCA
ATTGCTGGATTTTTCGCAGAACCTATTCAAGGTGTGAATGGAGTTGTCCAGTACCCAAAG
GGGTTTCTAAAGGAAGCCTTTGAGCTGGTGCGAGCAAGGGGAGGCGTGTGCATTGCAGAT
GAAGTGCAGACAGGATTTGGAAGGTTGGGCTCTCACTTCTGGGGCTTCCAAACCCACGAT
GTCCTGCCTGACATTGTCACCATGGCTAAAGGGATTGGGAATGGCTTTCCCATGGCAGCA
GTCATAACCACTCCAGAGATTGCCAAATCTTTGGCGAAATGCCTGCAGCACTTCAACACC
TTTGGAGGGAACCCCATGGCCTGTGCCATTGGATCTGCTGTGCTTGAGGTGATTAAAGAA
GAAAATCTACAGGAAAACAGTCAAGAAGTTGGGACCTACATGTTACTAAAGTTTGCTAAG
CTGCGGGATGAATTTGAAATTGTTGGAGACGTCCGAGGCAAAGGTCTCATGATAGGCATA
GAAATGGTGCAGGATAAGATAAGCTGTCGGCCTCTTCCCCGTGAAGAAGTAAATCAGATC
CATGAGGACTGCAAGCACATGGGACTCCTCGTTGGCAGAGGCAGCATTTTTTCTCAGACA
TTTCGCATTGCGCCCTCAATGTGCATCACTAAACCAGAAGTTGATTTTGCAGTAGAAGTA
TTTCGTTCTGCCTTAACCCAACACATGGAAAGAAGAGCTAAGTAA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
AJ292204

# Metabolic_Enzyme_10_Chromosome_Location:
Not Available

# Metabolic_Enzyme_10_Locus:
Not Available

# Metabolic_Enzyme_10_SNPs:
Not Available

# Metabolic_Enzyme_10_General_References:
Not Available

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5702

# Metabolic_Enzyme_11_Name:
Glycine amidinotransferase, mitochondrial precursor

# Metabolic_Enzyme_11_Synonyms:
L- arginine:glycine amidinotransferase; Transamidinase; AT

# Metabolic_Enzyme_11_Gene_Name:
GATM

# Metabolic_Enzyme_11_Protein_Sequence:
>Glycine amidinotransferase, mitochondrial precursor
MLRVRCLRGGSRGAEAVHYIGSRLGRTLTGWVQRTFQSTQAATASSRNSCAADDKATEPL
PKDCPVSSYNEWDPLEEVIVGRAENACVPPFTIEVKANTYEKYWPFYQKQGGHYFPKDHL
KKAVAEIEEMCNILKTEGVTVRRPDPIDWSLKYKTPDFESTGLYSAMPRDILIVVGNEII
EAPMAWRSRFFEYRAYRSIIKDYFHRGAKWTTAPKPTMADELYNQDYPIHSVEDRHKLAA
QGKFVTTEFEPCFDAADFIRAGRDIFAQRSQVTNYLGIEWMRRHLAPDYRVHIISFKDPN
PMHIDATFNIIGPGIVLSNPDRPCHQIDLFKKAGWTIITPPTPIIPDDHPLWMSSKWLSM
NVLMLDEKRVMVDANEVPIQKMFEKLGITTIKVNIRNANSLGGGFHCWTCDVRRRGTLQS
YLD

# Metabolic_Enzyme_11_Number_of_Residues:
423

# Metabolic_Enzyme_11_Molecular_Weight:
48456

# Metabolic_Enzyme_11_Theoretical_pI:
8.15

# Metabolic_Enzyme_11_GO_Classification:
Not Available

# Metabolic_Enzyme_11_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
L-arginine + glycine = L-ornithine + guanidinoacetate

# Metabolic_Enzyme_11_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_11_Reaction:
L-arginine + glycine = L-ornithine + guanidinoacetate

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF02274:Amidinotransf

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.1.4.1

# Metabolic_Enzyme_11_GenBank_ID_Protein:
545385

# Metabolic_Enzyme_11_SwissProt_ID:
GATM_HUMAN (P50440)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
GATM

# Metabolic_Enzyme_11_Geneatlas_id:
GATM

# Metabolic_Enzyme_11_hgnc_id:
HGNC:4175

# Metabolic_Enzyme_11_PDB_ID:
3JDW

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane; intermembrane side (Potential). Cytoplasm. Note=The mitochondrial form is found in the intermembrane space probably attached to the outer side of the inner membrane

# Metabolic_Enzyme_11_Gene_Sequence:
>1272 bp
ATGCTGCGGGTGCGGTGTCTGCGCGGCGGGAGCCGCGGCGCCGAGGCGGTGCACTACATC
GGATCTCGGCTTGGACGAACCTTGACAGGATGGGTGCAGCGAACTTTCCAGAGCACCCAG
GCAGCTACGGCTTCCTCCCGGAACTCCTGTGCAGCTGACGACAAAGCCACTGAGCCTCTG
CCCAAGGACTGCCCTGTCTCTTCTTACAACGAATGGGACCCCTTAGAGGAAGTGATAGTG
GGCAGAGCAGAAAACGCCTGTGTTCCACCGTTCACCATCGAGGTGAAGGCCAACACATAT
GAAAAGTACTGGCCATTTTACCAGAAGCAAGGAGGGCATTATTTTCCCAAAGATCATTTG
AAAAAGGCTGTTGCTGAAATTGAAGAAATGTGCAATATTTTAAAAACGGAAGGAGTGACA
GTAAGGAGGCCTGACCCCATTGACTGGTCATTGAAGTATAAAACTCCTGATTTTGAGTCT
ACGGGTTTATACAGTGCAATGCCTCGAGACATCCTGATAGTTGTGGGCAATGAGATTATC
GAGGCTCCCATGGCATGGCGTTCACGCTTCTTTGAGTACCGAGCGTACAGGTCAATTATC
AAAGACTACTTCCACCGTGGCGCCAAGTGGACAACAGCTCCTAAGCCCACAATGGCTGAT
GAGCTTTATAACCAGGATTATCCCATCCACTCTGTAGAAGACAGACACAAATTGGCTGCT
CAGGGAAAATTTGTGACAACTGAGTTTGAGCCATGCTTTGATGCTGCTGACTTCATTCGA
GCTGGAAGAGATATTTTTGCACAGAGAAGCCAGGTTACAAACTACCTAGGCATTGAATGG
ATGCGTAGGCATCTTGCTCCAGACTACAGAGTGCATATCATCTCCTTTAAAGATCCCAAT
CCCATGCATATTGATGCTACCTTCAACATCATTGGACCTGGTATTGTGCTTTCCAACCCT
GACCGACCATGTCACCAGATTGATCTTTTCAAGAAAGCAGGATGGACTATCATTACTCCT
CCAACACCAATCATCCCAGACGATCATCCACTCTGGATGTCATCCAAATGGCTTTCCATG
AATGTCTTAATGCTAGATGAAAAACGTGTTATGGTGGATGCCAATGAAGTTCCAATTCAA
AAGATGTTTGAAAAGCTGGGTATCACTACCATTAAAGTTAACATTCGTAATGCCAATTCC
CTGGGAGGAGGCTTCCATTGCTGGACCTGCGATGTCCGGCGCCGAGGCACCCTACAGTCC
TACTTGGACTGA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
S68805

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_11_Locus:
15q21.1

# Metabolic_Enzyme_11_SNPs:
rs1288775; rs1145086; rs3210028; rs1145080; rs1145077; rs1145081; rs1049508; rs4775937; rs1049518; rs12441971; rs8024550; rs7164602; rs1145079; rs11070454; rs1049503; rs1145084; rs1145078; rs1346268; rs17618637; rs12442696; rs16942568; rs12442078; rs16942588; rs1554521; rs2486274; rs3759899; rs1145085; rs12437887; rs1153854; rs1153855; rs12594857; rs12437840; rs2433611; rs10519022; rs9972498; rs2172874; rs7494956; rs1055395; rs17535381; rs1890565; rs1153857; rs8040380; rs12595087; rs2114501; rs17618783; rs1153856; rs1145076; rs1153858; rs1145089; rs4271549; rs4395020; rs4627277; rs4774579; rs4625670; rs8038342; rs4534782; rs12439575; rs4774580; rs9788780; rs16942663; rs34991226; rs1049491; rs3210030; rs3210027; rs3210026; rs3210029; rs3210025; rs16942529; rs1145083; rs11070455; rs9672959; rs12439919; rs35353298; rs1145082; rs36091209; rs2486273; rs1145087; rs28395435; rs1691665; rs11853955; rs34835251; rs16942536; rs2486272; rs28609657; rs34215740; rs35805543; rs34690026; rs2467850; rs7164139; rs34122808; rs11275645; rs2467851; rs1049511; rs35410548; rs1593621; rs34755569; rs1049502; rs11281225; rs34245967; rs1153853; rs6145546; rs28711439; rs2453543; rs36108646; rs9806260; rs2453542; rs12324848; rs35634173; rs34202663; rs35160985; rs12595153; rs5812296; rs35727417; rs11283178; rs9972528; rs2486275; rs9972405; rs3047502; rs5812295; rs35698201; rs28681101; rs28552543; rs3047503; rs34418487; rs34271244; rs11310088; rs34401164; rs10152697; rs10444821; rs11070453; rs11070456; rs11070457; rs1145090; rs1145091; rs1145093; rs1145094; rs1153851; rs1153859; rs1346267; rs1426932; rs2056493; rs2056494; rs2066090; rs2217121; rs2433604; rs2433608; rs2433609; rs2433610; rs2461702; rs2461704; rs2467862; rs2486271; rs4774577; rs4775911; rs7163751; rs7174251; rs8032904

# Metabolic_Enzyme_11_General_References:
8313955; 9148748; 9165070; 9218780; 9915841

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5278

# Metabolic_Enzyme_12_Name:
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor

# Metabolic_Enzyme_12_Synonyms:
AKB ligase; Glycine acetyltransferase; Aminoacetone synthetase

# Metabolic_Enzyme_12_Gene_Name:
GCAT

# Metabolic_Enzyme_12_Protein_Sequence:
>2amino3ketobutyrate coenzyme A ligase, mitochondrial precursor
MWPGNAWRAALFWVPRGRRAQSALAQLRGILEGELEGIRGAGTWKSERVITSRQGPHIRV
DGVSGGILNFCANNYLGLSSHPEVIQAGLQALEEFGAGLSSVRFICGTQSIHKNLEAKIA
RFHQREDAILYPSCYDANAGLFEALLTPEDAVLSDELNHASIIDGIRLCKAHKYRYRHLD
MADLEAKLQEAQKHRLRLVATDGAFSMDGDIAPLQEICCLASRYGALVFMDECHATGFLG
PTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTGPGPLVSLLRQRARPYLFSNSLPP
AVVGCASKALDLLMGSNTIVQSMAAKTQRFRSKMEAAGFTISGASHPICPVMLGDARLAS
RMADDMLKRGIFVIGFSYPVVPKGKARIRVQISAVHSEEDIDRCVEAFVEVGRLHGALP

# Metabolic_Enzyme_12_Number_of_Residues:
419

# Metabolic_Enzyme_12_Molecular_Weight:
45286

# Metabolic_Enzyme_12_Theoretical_pI:
8.11

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  transferase activity, transferring nitrogenous groups
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
Function:  acetyltransferase activity
Function:  C-acetyltransferase activity
Function:  glycine C-acetyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_12_Specific_Function:
Acetyl-CoA + glycine = CoA + 2-amino-3- oxobutanoate

# Metabolic_Enzyme_12_Pathway:
map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_12_Reaction:
acetyl-CoA + glycine = CoA + 2-amino-3-oxobutanoate

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_12_Signals:
1-20

# Metabolic_Enzyme_12_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 2.3.1.29

# Metabolic_Enzyme_12_GenBank_ID_Protein:
3342906

# Metabolic_Enzyme_12_SwissProt_ID:
KBL_HUMAN (O75600)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
GCAT

# Metabolic_Enzyme_12_Geneatlas_id:
GCAT

# Metabolic_Enzyme_12_hgnc_id:
HGNC:4188

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_12_Gene_Sequence:
>1260 bp
ATGTGGCCTGGGAACGCCTGGCGCGCCGCACTCTTCTGGGTGCCCCGCGGCCGCCGCGCA
CAGTCAGCGCTGGCCCAGCTGCGTGGCATTCTGGAGGGGGAGCTGGAAGGCATCCGCGGA
GCTGGCACTTGGAAGAGTGAGCGGGTCATCACGTCCCGTCAGGGGCCGCACATCCGCGTG
GACGGCGTCTCCGGAGGAATCCTCAACTTCTGTGCCAACAACTACCTGGGCCTGAGCAGC
CACCCTGAGGTGATTCAGGCAGGTCTGCAGGCTCTGGAGGAGTTTGGAGCTGGCCTTAGC
TCGGTCCGCTTCATCTGTGGAACCCAGAGCATCCACAAGAATCTAGAAGCAAAAATAGCC
CGCTTCCACCAGCGGGAGGATGCCATCCTCTATCCCAGCTGTTATGACGCCAACGCCGGC
CTCTTTGAGGCCCTGCTGACCCCAGAGGACGCAGTCCTGTCGGACGAGCTGAACCATGCC
TCCATCATCGACGGCATCCGGCTGTGCAAGGCCCACAAGTACCGCTATCGCCACCTGGAC
ATGGCCGACCTAGAAGCCAAGCTGCAGGAGGCCCAGAAGCATCGGCTGCGCCTGGTGGCC
ACCGATGGGGCCTTTTCCATGGATGGCGACATCGCACCCCTGCAGGAGATCTGCTGCCTC
GCCTCTAGATATGGTGCCCTGGTCTTCATGGATGAATGCCATGCCACTGGTTTCCTGGGG
CCCACAGGACGGGGCACAGATGAGCTGCTGGGTGTGATGGACCAGGTCACCATCATCAAC
TCCACCCTGGGGAAGGCCCTGGGTGGAGCATCAGGGGGCTACACGACAGGGCCTGGGCCC
CTGGTGTCACTGCTGCGGCAGCGCGCCCGGCCATACCTCTTCTCCAACAGTCTGCCACCT
GCTGTCGTTGGCTGCGCCTCCAAGGCCCTAGATCTGCTGATGGGGAGTAACACCATTGTC
CAGTCTATGGCTGCCAAGACCCAGAGGTTCCGTAGTAAGATGGAAGCTGCTGGCTTCACT
ATCTCAGGAGCCAGTCACCCCATCTGCCCTGTGATGCTGGGTGATGCCCGGCTGGCCTCT
CGCATGGCGGATGACATGCTGAAGAGAGGCATCTTTGTCATCGGGTTCAGCTACCCCGTG
GTCCCCAAGGGCAAGGCCCGGATCCGGGTACAGATCTCAGCAGTGCATAGCGAGGAAGAC
ATTGACCGCTGCGTGGAGGCCTTCGTGGAAGTGGGGCGACTGCACGGGGCACTGCCCTGA


# Metabolic_Enzyme_12_GenBank_ID_Gene:
AF077740

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_12_Locus:
22q13.1

# Metabolic_Enzyme_12_SNPs:
rs34468367; rs34340481; rs13911; rs2285177; rs2246503; rs2071910; rs2285178; rs2285179; rs739269; rs11089856; rs929104; rs5995500; rs763137; rs5750499; rs12628125; rs8142046; rs11703517; rs12484820; rs2017022; rs2269617; rs13055959; rs35749384; rs34003565; rs17856459; rs1048176; rs3041699; rs35692733; rs11913587; rs5845354; rs12628459; rs4320026; rs5995501; rs35401651; rs3041696; rs11430257; rs8139863; rs35914466; rs13058437; rs35339676; rs12484783; rs5756827; rs36110853; rs34576063; rs9610853; rs34071068; rs36009767; rs9622702; rs12484901; rs5845356; rs7290658; rs34452073; rs34227294; rs1050466; rs11703407; rs12160750; rs15973; rs1800694; rs1894644; rs1894645; rs1894646; rs2284057; rs2284058; rs4821716; rs4821717; rs5756825; rs5995498; rs6000897; rs7290156; rs739267; rs8137541; rs8140423

# Metabolic_Enzyme_12_General_References:
10712613; 10591208

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5438

# Metabolic_Enzyme_13_Name:
D-amino-acid oxidase

# Metabolic_Enzyme_13_Synonyms:
DAMOX; DAO; DAAO

# Metabolic_Enzyme_13_Gene_Name:
DAO

# Metabolic_Enzyme_13_Protein_Sequence:
>Daminoacid oxidase
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPN
NPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPR
ELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVN
CTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGG
IFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGP
SNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL

# Metabolic_Enzyme_13_Number_of_Residues:
347

# Metabolic_Enzyme_13_Molecular_Weight:
39475

# Metabolic_Enzyme_13_Theoretical_pI:
6.84

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
Function:  D-amino-acid oxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_13_Specific_Function:
Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids

# Metabolic_Enzyme_13_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00472  D-Arginine and D-ornithine metabolism

# Metabolic_Enzyme_13_Reaction:
a D-amino acid + H2O + O2 = a 2-oxo acid + ammonia + H2O2

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF01266:DAO

# Metabolic_Enzyme_13_Signals:
1-16

# Metabolic_Enzyme_13_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 1.4.3.3

# Metabolic_Enzyme_13_GenBank_ID_Protein:
30446

# Metabolic_Enzyme_13_SwissProt_ID:
OXDA_HUMAN (P14920)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
DAO

# Metabolic_Enzyme_13_Geneatlas_id:
DAO

# Metabolic_Enzyme_13_hgnc_id:
HGNC:2671

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_13_Gene_Sequence:
>1044 bp
ATGCGTGTGGTGGTGATTGGAGCAGGAGTCATCGGGCTGTCCACCGCCCTCTGCATCCAT
GAGCGCTACCACTCAGTCCTGCAGCCACTGCACATAAAGGTCTACGCGGACCGCTTCACC
CCACTCACCACCACCGACGTGGCTGCCGGCCTCTGGCAGCCCTACCTTTCTGACCCCAAC
AACCCACAGGAGGCGGACTGGAGCCAACAGACCTTTGACTATCTCCTGAGCCATGTCCAT
TCTCCCAACGCTGAAAACCTGGGCCTGTTCCTAATCTCGGGCTACAACCTCTTCCATGAA
GCCATTCCGGACCCTTCCTGGAAGGACACAGTTCTGGGATTTCGGAAGCTGACCCCCAGA
GAGCTGGATATGTTCCCAGATTACGGCTATGGCTGGTTCCACACAAGCCTAATTCTGGAG
GGAAAGAACTATCTACAGTGGCTGACTGAAAGGTTAACTGAGAGGGGAGTGAAGTTCTTC
CAGCGGAAAGTGGAGTCTTTTGAGGAGGTGGCAAGAGAAGGCGCAGACGTGATTGTCAAC
TGCACTGGGGTATGGGCTGGGGCGCTACAACGAGACCCCCTGCTGCAGCCAGGCCGGGGG
CAGATCATGAAGGTGGACGCCCCTTGGATGAAGCACTTCATTCTCACCCATGACCCAGAG
AGAGGCATCTACAATTCCCCGTACATCATCCCAGGGACCCAGACAGTTACTCTTGGAGGC
ATCTTCCAGTTGGGAAACTGGAGTGAACTAAACAATATCCAGGACCACAACACCATTTGG
GAAGGCTGCTGCAGACTGGAGCCCACACTGAAGAATGCAAGAATTATTGGTGAAGCAACT
GGCTTCCGGCCAGTACGCCCCCAGATTCGGCTAGAAAGAGAACAGCTTCGCACTGGACCT
TCAAACACAGAGGTCATCCACAACTATGGCCATGGAGGCTACGGGCTCACCATCCACTGG
GGATGTGCCCTGGAGGCAGCCAAGCTCTTTGGGAGAATCCTGGAAGAAAAGAAATTGTCC
AGAATGCCACCATCCCACCTCTGA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
X13227

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_13_Locus:
12q24

# Metabolic_Enzyme_13_SNPs:
rs7980427; rs2111902; rs7977762; rs4964767; rs17041020; rs12579920; rs4964766; rs2070588; rs11114083; rs9706062; rs2070586; rs4964765; rs7316889; rs2070585; rs2070587; rs1808351; rs11830725; rs3741775; rs11114086; rs11114085; rs6539458; rs3918347; rs6539460; rs10861974; rs4964281; rs11837302; rs3918346; rs7967441; rs11114084; rs11114087; rs12426462; rs6539459; rs6539462; rs2302882; rs3741774; rs4964280; rs17041050; rs17041074; rs9669254; rs3825251; rs12229954; rs6539461; rs17041058; rs7962665; rs17041040; rs7975723; rs10778658; rs3741776; rs17041039; rs7302245; rs4623951; rs10861973; rs7965821; rs35388422; rs4262766; rs35658778; rs4644682; rs35550859; rs34135554; rs11415772; rs762451; rs34780883; rs11417050; rs1053875; rs3741773; rs35481176; rs11611767; rs10689951; rs10696805; rs4989798; rs35363883; rs28868909; rs12810412; rs11301485; rs34552650; rs35324225; rs7134038; rs36013571; rs7967357; rs35521446; rs4989799; rs35572480; rs36104885; rs9668314; rs5800839; rs12811324; rs11420034; rs11335673; rs11464907; rs11402329; rs11356161; rs9668327; rs7138366; rs35258241; rs34666571; rs35167645; rs10599880; rs35681690; rs12810212; rs10778659; rs12830695; rs35356685; rs36032329; rs11114080; rs11114081; rs34178394; rs10861977; rs1129027; rs12308912; rs4964762; rs4964770; rs7294679; rs7308400; rs7958090

# Metabolic_Enzyme_13_General_References:
2901986; 1356107

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5686

# Metabolic_Enzyme_14_Name:
Aminopeptidase N

# Metabolic_Enzyme_14_Synonyms:
hAPN; Alanyl aminopeptidase; Microsomal aminopeptidase; Aminopeptidase M; gp150; Myeloid plasma membrane glycoprotein CD13; CD13 antigen

# Metabolic_Enzyme_14_Gene_Name:
ANPEP

# Metabolic_Enzyme_14_Protein_Sequence:
>Aminopeptidase 
NMAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNP
ASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDV
IIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMD
SEFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIH
PKDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVL
IRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGL
VTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEY
LGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSK
GASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDI
MNRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQD
YWLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRA
QIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMK
NYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQW
MENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELW
ILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFS
NLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVL
QWFTENSK

# Metabolic_Enzyme_14_Number_of_Residues:
967

# Metabolic_Enzyme_14_Molecular_Weight:
109540

# Metabolic_Enzyme_14_Theoretical_pI:
5.14

# Metabolic_Enzyme_14_GO_Classification:
Not Available

# Metabolic_Enzyme_14_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection

# Metabolic_Enzyme_14_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_14_Reaction:
Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide

# Metabolic_Enzyme_14_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_14_Signals:
1-22

# Metabolic_Enzyme_14_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 3.4.11.2

# Metabolic_Enzyme_14_GenBank_ID_Protein:
28678

# Metabolic_Enzyme_14_SwissProt_ID:
AMPN_HUMAN (P15144)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
ANPEP

# Metabolic_Enzyme_14_Geneatlas_id:
ANPEP

# Metabolic_Enzyme_14_hgnc_id:
HGNC:500

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Cytoplasm; cytosol (Potential). Note=A soluble form has also been detected

# Metabolic_Enzyme_14_Gene_Sequence:
>2904 bp
ATGGCCAAGGGCTTCTATATTTCCAAGTCCCTGGGCATCCTGGGGATCCTCCTGGGCGTG
GCAGCCGTGTGCACAATCATCGCACTGTCAGTGGTGTACTCCCAGGAGAAGAACAAGAAC
GCCAACAGCTCCCCCGTGGCCTCCACCACCCCGTCCGCCTCAGCCACCACCAACCCCGCC
TCGGCCACCACCTTGGACCAAAGTAAAGCGTGGAATCGTTACCGCCTCCCCAACACGCTG
AAACCCGATTCCTACCAGGTGACGCTGAGACCGTACCTCACCCCCAATGACAGGGGCCTG
TACGTTTTTAAGGGCTCCAGCACCGTCCGTTTCACCTGCAAGGAGGCCACTGACGTCATC
ATCATCCACAGCAAGAAGCTCAACTACACCCTCAGCCAGGGGCACAGGGTGGTCCTGCGT
GGTGTGGGAGGCTCCCAGCCCCCCGACATTGACAAGACTGAGCTGGTGGAGCCCACCGAG
TACCTGGTGGTGCACCTCAAGGGCTCCCTGGTGAAGGACAGCCAGTATGAGATGGACAGC
GAGTTCGAGGGGGAGTTGGCAGATGACCTGGCGGGCTTCTACCGCAGCGAGTACATGGAG
GGCAATGTCAGAAAGGTGGTGGCCACTACACAGATGCAGGCTGCAGATGCCCGGAAGTCC
TTCCCATGCTTCGATGAGCCGGCCATGAAGGCCGAGTTCAACATCACGCTTATCCACCCC
AAGGACCTGACAGCCCTGTCCAACATGCTTCCCAAAGGTCCCAGCACCCCACTTCCAGAA
GACCCCAACTGGAATGTCACTGAGTTCCACACCACGCCCAAGATGTCCACGTACTTGCTG
GCCTTCATTGTCAGTGAGTTCGACTACGTGGAGAAGCAGGCATCCAATGGTGTCTTGATC
CGGATCTGGGCCCGGCCCAGTGCCATTGCGGCGGGCCACGGCGATTATGCCCTGAACGTG
ACGGGCCCCATCCTTAACTTCTTTGCTGGTCATTATGACACACCCTACCCACTCCCAAAA
TCAGACCAGATTGGCCTGCCAGACTTCAACGCCGGCGCCATGGAGAACTGGGGACTGGTG
ACCTACCGGGAGAACTCCCTGCTGTTCGACCCCCTGTCCTCCTCCAGCAGCAACAAGGAG
CGGGTGGTCACTGTGATTGCTCATGAGCTGGCCCACCAGTGGTTCGGGAACCTGGTGACC
ATAGAGTGGTGGAATGACCTGTGGCTGAACGAGGGCTTCGCCTCCTACGTGGAGTACCTG
GGTGCTGACTATGCGGAGCCCACCTGGAACTTGAAAGACCTCATGGTGCTGAATGATGTG
TACCGCGTGATGGCAGTGGATGCACTGGCCTCCTCCCACCCGCTGTCCACACCCGCCTCG
GAGATCAACACGCCGGCCCAGATCAGTGAGCTGTTTGACGCCATCTCCTACAGCAAGGGC
GCCTCAGTCCTCAGGATGCTCTCCAGCTTCCTGTCCGAGGACGTATTCAAGCAGGGCCTG
GCGTCCTACCTCCACACCTTTGCCTACCAGAACACCATCTACCTGAACCTGTGGGACCAC
CTGCAGGAGGCTGTGAACAACCGGTCCATCCAACTCCCCACCACCGAGCGGGACATCATG
AACCGCTGGACCCTGCAGATGGGCTTCCCGGTCATCACGGTGGATACCAGCACGGGGACC
CTTTCCCAGGAGCACTTCCTCCTTGACCCCGATTCCAATGTTACCCGCCCCTCAGAATTC
AACTACGTGTGGATTGTGCCCATCACATCCATCAGAGATGGCAGACAGCAGCAGGACTAC
TGGCTGATGGATGTAAGAGCCCAGAACGATCTCTTCAGCACATCAGGCAATGAGTGGGTC
CTGCTGAACCTCAATGTGACGGGCTATTACCGGGTGAACTACGACGAAGAGAACTGGAGG
AAGATTCAGACTCAGCTGCAGAGAGACCACTCGGCCATCCCTGTCATCAATCGGGCACAG
ATCATTAATGACGCCTTCAACCTGGCCAGTGCCCATAAGGTCCCTGTCACTCTGGCGCTG
AACAACACCCTCTTCCTGATTGAAGAGAGACAGTACATGCCCTGGGAGGCCGCCCTGAGC
AGCCTGAGCTACTTCAAGCTCATGTTTGACCGCTCCGAGGTCTATGGCCCCATGAAGAAC
TACCTGAAGAAGCAGGTCACACCCCTCTTCATTCACTTCAGAAATAATACCAACAACTGG
AGGGAGATCCCAGAAAACCTGATGGACCAGTACAGCGAGGTTAATGCCATCAGCACCGCC
TGCTCCAACGGAGTTCCAGAGTGTGAGGAGATGGTCTCTGGCCTTTTCAAGCAGTGGATG
GAGAACCCCAATAATAACCCGATCCACCCCAACCTGCGGTCCACCGTCTACTGCAACGCT
ATCGCCCAGGGCGGGGAGGAGGAGTGGGACTTCGCCTGGGAGCAGTTCCGAAATGCCACA
CTGGTCAATGAGGCTGACAAGCTCCGGGCAGCCCTGGCCTGCAGCAAAGAGTTGTGGATC
CTGAACAGGTACCTGAGCTACACCCTGAACCCGGACTTAATCCGGAAGCAGGACGCCACC
TCTACCATCATCAGCATTACCAACAACGTCATTGGGCAAGGTCTGGTCTGGGACTTTGTC
CAGAGCAACTGGAAGAAGCCTTTTAACGATTATGGTGGTGGCTCGTTCTCCTTCTCCAAC
CTCATCCAGGCAGTGACACGACGATTCTCCACCGAGTATGAGCTGCAGCAGCTGGAGCAG
TTCAAGAAGGACAACGAGGAAACAGGCTTCGGCTCAGGCACCCGGGCCCTGGAGCAAGCC
CTGGAGAAGACGAAAGCCAACATCAAGTGGGTGAAGGAGAACAAGGAGGTGGTGCTCCAG
TGGTTCACAGAAAACAGCAAATAG

# Metabolic_Enzyme_14_GenBank_ID_Gene:
X13276

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_14_Locus:
15q25-q26

# Metabolic_Enzyme_14_SNPs:
rs25653; rs8192297; rs17240268; rs25651; rs17240212; rs17240240; rs25654; rs25652; rs10584; rs1439118; rs6496603; rs893615; rs1439121; rs1992250; rs8035491; rs753362; rs12909844; rs8192299; rs6496604; rs16943605; rs7169049; rs7168329; rs17239917; rs2305443; rs16943599; rs6496605; rs7168849; rs7169161; rs7166568; rs8192300; rs16943590; rs16974177; rs12324351; rs1439119; rs1439117; rs12437542; rs9672394; rs11857171; rs8036014; rs2305444; rs1439120; rs7167568; rs11857950; rs11854430; rs8192298; rs2007084; rs3934; rs16974181; rs10152918; rs6496606; rs893616; rs8035089; rs751218; rs8034807; rs967451; rs13380049; rs12921; rs8179192; rs10152474; rs1042550; rs8179195; rs8179199; rs41276922; rs8192296; rs41276916; rs1803099; rs41276910; rs1042524; rs1803100; rs8192295; rs11548402; rs5017001; rs1042499; rs28760317; rs41276918; rs10596905; rs28569158; rs34455433; rs755494; rs8192301; rs28546242; rs8179198; rs8192294; rs8023978; rs28512252; rs28454285; rs28826912; rs35119955; rs10596904; rs34462972; rs28699258; rs28375428; rs35916600; rs8043481; rs41276912; rs3214806; rs28463231; rs34392936; rs28545693; rs8039818; rs28639834; rs28787610; rs8192302; rs35107174; rs28588889; rs35792576; rs28626435; rs10652893; rs28731015; rs34558689; rs28404753; rs28445667; rs8179197; rs36038374; rs11419701; rs35929320; rs28465343; rs11396899; rs934922; rs35626130; rs35391151; rs28654076; rs8024295; rs28462367; rs34396448; rs28621548; rs28493892; rs8030846; rs41276920; rs35499425; rs28422990; rs28638060; rs28380038; rs8028356; rs8031558; rs35579820; rs8025757; rs8192293; rs33964101; rs28556743; rs10643405; rs35273925; rs10683900; rs35962063; rs41276914; rs28591352; rs11428754; rs34474497; rs34493756; rs28459313; rs28496328; rs35408448; rs7175307; rs41276924; rs28368179; rs28698386; rs16943583; rs28460748; rs13380065; rs4932142; rs28575419; rs35816703; rs34025860; rs11073889; rs11632886; rs11636959; rs11857170; rs12900413; rs12908026; rs12908343; rs12908545; rs12910894; rs12913572; rs1561459; rs3929141; rs8041622

# Metabolic_Enzyme_14_General_References:
2901990; 2564851; 1675638; 7576235; 8102610; 6149934; 1705556; 1350662; 7902291; 8105105; 8887485; 9056417; 9367365; 9634079; 10605003; 10676659; 11384645; 11559807; 12473585; 12551991; 9452074

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
6074

# Metabolic_Enzyme_15_Name:
Serine hydroxymethyltransferase, cytosolic

# Metabolic_Enzyme_15_Synonyms:
Serine methylase; Glycine hydroxymethyltransferase; SHMT

# Metabolic_Enzyme_15_Gene_Name:
SHMT1

# Metabolic_Enzyme_15_Protein_Sequence:
>Serine hydroxymethyltransferase, cytosolic
MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA
VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG
SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV
VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL
QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL
VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK
VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL
PDF

# Metabolic_Enzyme_15_Number_of_Residues:
483

# Metabolic_Enzyme_15_Molecular_Weight:
53083

# Metabolic_Enzyme_15_Theoretical_pI:
7.77

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  glycine hydroxymethyltransferase activity
 ||
>>>
Process:  L-serine metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_15_Specific_Function:
Interconversion of serine and glycine

# Metabolic_Enzyme_15_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00310  Lysine degradation;
 map00460  Cyanoamino acid metabolism;
 map00670  One carbon pool by folate;
 map00680  Methane metabolism

# Metabolic_Enzyme_15_Reaction:
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00464:SHMT

# Metabolic_Enzyme_15_Signals:
None

# Metabolic_Enzyme_15_Transmembrane_Regions:
None

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 2.1.2.1

# Metabolic_Enzyme_15_GenBank_ID_Protein:
307422

# Metabolic_Enzyme_15_SwissProt_ID:
GLYC_HUMAN (P34896)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
SHMT1

# Metabolic_Enzyme_15_Geneatlas_id:
SHMT1

# Metabolic_Enzyme_15_hgnc_id:
HGNC:10850

# Metabolic_Enzyme_15_PDB_ID:
1BJ4

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_15_Gene_Sequence:
>1452 bp
ATGACGATGCCAGTCAACGGGGCCCACAAGGATGCTGACCTGTGGTCCTCACATGACAAG
ATGCTGGCACAACCCCTCAAAGACAGTGATGTTGAGGTTTACAACATCATTAAGAAGGAG
AGTAACCGGCAGAGGGTTGGATTGGAGCTGATTGCCTCGGAGAATTTCGCCAGCCGAGCA
GTTTTGGAGGCCCTAGGCTCTTGCTTAAATAACAAATACTCTGAGGGGTACCCGGGCCAG
AGATACTATGGCGGGACTGAGTTTATTGATGAACTGGAGACCCTCTGTCAGAAGCGAGCC
CTGCAGGCCTATAAGCTGGACCCACAGTGCTGGGGGGTCAACGTCCAGCCCTACTCAGGC
TCCCCTGCAAACTTTGCTGTGTACACTGCCCTGGTGGAACCCCATGGGCGCATCATGGGC
CTGGACCTTCCGGATGGGGGCCACCTGACCCATGGGTTCATGACAGACAAGAAGAAAATC
TCTGCCACGTCCATCTTCTTTGAATCTATGCCCTACAAGGTGAACCCAGATACTGGCTAC
ATCAACTATGACCAGCTGGAGGAGAACGCACGCCTCTTCCACCCGAAGCTGATCATCGCA
GGAACCAGCTGCTACTCCCGAAACCTGGAATATGCCCGGCTACGGAAGATTGCAGATGAG
AACGGGGCGTATCTCATGGCGGACATGGCTCACATCAGCGGGCTGGTGGCGGCTGGCGTG
GTGCCCTCCCCATTTGAACACTGCCATGTGGTGACCACCACCACTCACAAGACCCTGCGA
GGCTGCCGAGCTGGCATGATCTTCTACAGGAAAGGAGTGAAAAGTGTGGATCCCAAGACT
GGCAAAGAGATTCTGTACAACCTGGAGTCTCTTATCAATTCTGCTGTGTTCCCTGGCCTG
CAGGGAGGTCCCCACAACCACGCCATTGCTGGGGTTGCTGTGGCACTGAAGCAAGCTATG
ACTCTGGAATTTAAAGTTTATCAACACCAGGTGGTGGCCAACTGCAGGGCTCTGTCTGAG
GCCCTGACGGAGCTGGGCTACAAAATAGTCACAGGTGGTTCTGACAACCATTTGATCCTT
GTGGATCTCCGTTCCAAAGGCACAGATGGTGGAAGGGCTGAGAAGGTGCTAGAAGCCTGT
TCTATTGCCTGCAACAAGAACACCTGTCCAGGTGACAGAAGCGCTCTGCGGCCCAGTGGA
CTGCGGCTGGGGACCCCAGCACTGACGTCCCGTGGACTTTTGGAAAAAGACTTCCAAAAA
GTAGCCCACTTTATTCACAGAGGGATAGAGCTGACCCTGCAGATCCAGAGCGACACTGGT
GTCAGAGCCACCCTGAAAGAGTTCAAGGAGAGACTGGCAGGGGATAAGTACCAGGCGGCC
GTGCAGGCTCTCCGGGAGGAGGTTGAGAGCTTCGCCTCTCTCTTCCCTCTGCCTGGCCTG
CCTGACTTCTAA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
L11931

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_15_Locus:
17p11.2

# Metabolic_Enzyme_15_SNPs:
rs1979277; rs7215148; rs3783; rs1979276; rs4924750; rs12952556; rs2688030; rs7211382; rs2688036; rs9902011; rs9901707; rs11867855; rs12602780; rs2273027; rs6502648; rs2125154; rs2168781; rs4925177; rs2273029; rs4925178; rs9909104; rs4924848; rs2273028; rs4500798; rs4924849; rs9904323; rs9902498; rs9910090; rs11868708; rs2273026; rs4925176; rs7215241; rs4925174; rs17806489; rs8080285; rs12937300; rs4925175; rs7215491; rs9897954; rs6502649; rs7207306; rs11078415; rs11869515; rs3794772; rs12603682; rs1975822; rs9899244; rs12451555; rs12601687; rs8070633; rs8070162; rs7217566; rs6502650; rs12939092; rs8073464; rs7216214; rs4925180; rs638318; rs9748196; rs1975821; rs4925179; rs12451698; rs6502652; rs12949119; rs12939757; rs593297; rs10560621; rs12950117; rs12603525; rs10605292; rs2045463; rs10560620; rs1801438; rs9907815; rs34046905; rs6502651; rs28842509; rs35758894; rs35958900; rs599147; rs12603622; rs3866955; rs35176939; rs34396945; rs35675509; rs36074773; rs4924850; rs9893653; rs9891958; rs11652808; rs640629; rs28479066; rs8076444; rs35371970; rs35017109; rs9890189; rs9890744; rs12451807; rs7222930; rs9915858; rs34314562; rs3039790; rs10163522; rs8074044; rs641028; rs12952667; rs35782384; rs8074369; rs3794773; rs35005892; rs41313224; rs35818260; rs11415006; rs33997817; rs8080168; rs34157006; rs36102200; rs10655994; rs11649868; rs28823869; rs35253049; rs12450760; rs9901339; rs9905667; rs28895954; rs7219549; rs35552686; rs11649727; rs28893340; rs28630807; rs34568590; rs34135775; rs17806333; rs10669899; rs35431354; rs11659056; rs11658098; rs11649725; rs35628660; rs9891024; rs7217603; rs941454; rs2461837; rs2461838; rs4924845; rs4924846; rs4924847; rs4925169; rs4925170; rs4925171; rs4925172; rs4925173; rs638416; rs643333; rs6502646; rs669340; rs672356; rs7213472; rs8065874; rs921865; rs921866; rs921985; rs921986; rs9894406; rs9898323; rs9900382; rs9901160; rs9906010; rs9907337; rs9909530; rs9913022

# Metabolic_Enzyme_15_General_References:
8505317; 9056951; 9753690

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5837

# Metabolic_Enzyme_16_Name:
Glycyl-tRNA synthetase

# Metabolic_Enzyme_16_Synonyms:
Glycine--tRNA ligase; GlyRS

# Metabolic_Enzyme_16_Gene_Name:
GARS

# Metabolic_Enzyme_16_Protein_Sequence:
>GlycyltRNA synthetase
MPSPRPVLLRGARAALLLLLPPRLLARPSLLLRRSLSAASCAPISLPAAASRSSMDGAGA
EEVLAPLRLAVRQQGDLVRKLKEDKAPQVDVDKAVAELKARKRVLEAKELALQPKDDIVD
RAKMEDTLKRRFFYDQAFAIYGGVSGLYDFGPVGCALKNNIIQTWRQHFIQEEQILEIDC
TMLTPEPVLKTSGHVDKFADFMVKDVKNGECFRADHLLKAHLQKLMSDKKCSVEKKSEME
SVLAQLDNYGQQELADLFVNYNVKSPITGNDLSPPVSFNLMFKTFIGPGGNMPGYLRPET
AQGIFLNFKRLLEFNQGKLPFAAAQIGNSFRNEISPRSGLIRVREFTMAEIEHFVDPSEK
DHPKFQNVADLHLYLYSAKAQVSGQSARKMRLGDAVEQGVINNTVLGYFIGRIYLYLTKV
GISPDKLRFRQHMENEMAHYACDCWDAESKTSYGWIEIVGCADRSCYDLSCHARATKVPL
VAEKPLKEPKTVNVVQFEPSKGAIGKAYKKDAKLVMEYLAICDECYITEMEMLLNEKGEF
TIETEGKTFQLTKDMINVKRFQKTLYVEEVVPNVIEPSFGLGRIMYTVFEHTFHVREGDE
QRTFFSFPAVVAPFKCSVLPLSQNQEFMPFVKELSEALTRHGVSHKVDDSSGSIGRRYAR
TDEIGVAFGVTIDFDTVNKTPHTATLRDRDSMRQIRAEISELPSIVQDLANGNITWADVE
ARYPLFEGQETGKKETIEE

# Metabolic_Enzyme_16_Number_of_Residues:
739

# Metabolic_Enzyme_16_Molecular_Weight:
83140

# Metabolic_Enzyme_16_Theoretical_pI:
7.04

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  glycine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  glycyl-tRNA aminoacylation
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  protein biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_16_Specific_Function:
ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)

# Metabolic_Enzyme_16_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_16_Reaction:
ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF03129:HGTP_anticodon;
PF00587:tRNA-synt_2b;
PF00458:WHEP-TRS

# Metabolic_Enzyme_16_Signals:
1-26

# Metabolic_Enzyme_16_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 6.1.1.14

# Metabolic_Enzyme_16_GenBank_ID_Protein:
1311463

# Metabolic_Enzyme_16_SwissProt_ID:
SYG_HUMAN (P41250)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
GARS

# Metabolic_Enzyme_16_Geneatlas_id:
GARS

# Metabolic_Enzyme_16_hgnc_id:
HGNC:4162

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Not Available

# Metabolic_Enzyme_16_Gene_Sequence:
>2220 bp
ATGCCCTCTCCGCGTCCAGTGCTGCTTAGAGGTGCTCGCGCCGCTCTGCTGCTGCTGCTG
CCGCCCCGGCTCTTAGCCCGACCCTCGCTCCTGCTCCGCCGGTCCCTCAGCGCGGCCTCC
TGCGCCCCGATCTCCTTGCCCGCCGCCGCCTCCCGGAGCAGCATGGACGGCGCGGGGGCT
GAGGAGGTGCTGGCACCTCTGAGGCTAGCAGTGCGCCAGCAGGGAGATCTTGTGCGAAAA
CTCAAAGAAGATAAAGCACCCCAAGTAGACGTAGACAAAGCAGTGGCTGAGCTCAAAGCC
CGCAAGAGGGTTCTGGAAGCAAAGGAGCTGGCGTTACAGCCCAAAGATGATATTGTAGAC
CGAGCAAAAATGGAAGATACCCTGAAGAGGAGGTTTTTCTATGATCAAGCTTTTGCTATT
TATGGAGGTGTTAGTGGTCTGTATGACTTTGGGCCAGTTGGCTGTGCTTTGAAGAACAAT
ATTATTCAGACCTGGAGGCAGCACTTTATCCAAGAGGAACAGATCCTGGAGATCGATTGC
ACCATGCTCACCCCTGAGCCAGTTTTAAAGACCTCTGGCCATGTAGACAAATTTGCTGAC
TTCATGGTGAAAGACGTAAAAAATGGAGAATGTTTTCGTGCTGACCATCTATTAAAAGCT
CATTTACAGAAATTGATGTCTGATAAGAAGTGTTCTGTCGAAAAGAAATCAGAAATGGAA
AGTGTTTTGGCCCAGCTTGATAACTATGGACAGCAAGAACTTGCGGATCTTTTTGTGAAC
TATAATGTAAAATCTCCCATTACTGGAAATGATCTATCCCCTCCAGTGTCTTTTAACTTA
ATGTTCAAGACTTTCATTGGGCCTGGAGGAAACATGCCTGGGTACTTGAGACCAGAAACT
GCACAGGGGATTTTCTTGAATTTCAAACGACTTTTGGAGTTCAACCAAGGAAAGTTGCCT
TTTGCTGCTGCCCAGATTGGAAATTCTTTTAGAAATGAGATCTCCCCTCGATCTGGACTG
ATCAGAGTCAGAGAATTCACAATGGCAGAAATTGAGCACTTTGTAGATCCCAGTGAGAAA
GACCACCCCAAGTTCCAGAATGTGGCAGACCTTCACCTTTATTTGTATTCAGCAAAAGCC
CAGGTCAGCGGACAGTCCGCTCGGAAAATGCGCCTGGGAGATGCTGTTGAACAGGGTGTG
ATTAATAACACAGTATTAGGCTATTTCATTGGCCGCATCTACCTCTACCTCACGAAGGTT
GGAATATCTCCAGATAAACTCCGCTTCCGGCAGCACATGGAGAATGAGATGGCCCATTAT
GCCTGTGACTGTTGGGATGCAGAATCCAAAACATCCTACGGTTGGATTGAGATTGTTGGA
TGTGCTGATCGTTCCTGTTATGACCTCTCCTGTCATGCACGAGCCACCAAAGTCCCACTT
GTAGCTGAGAAACCTCTGAAAGAACCCAAAACAGTCAATGTTGTTCAGTTTGAACCCAGT
AAGGGAGCAATTGGTAAGGCATATAAGAAGGATGCAAAACTGGTGATGGAGTATCTTGCC
ATTTGTGATGAGTGCTACATTACAGAAATGGAGATGCTGCTGAATGAGAAAGGGGAATTC
ACAATTGAAACTGAAGGGAAAACATTTCAGTTAACAAAAGACATGATCAATGTGAAGAGA
TTCCAGAAAACACTATATGTGGAAGAAGTTGTTCCGAATGTAATTGAACCTTCCTTCGGC
CTGGGTAGGATCATGTATACGGTATTTGAACATACATTCCATGTACGAGAAGGAGATGAA
CAGAGAACATTCTTCAGTTTCCCTGCTGTAGTTGCTCCATTCAAATGTTCCGTCCTCCCA
CTGAGCCAAAACCAGGAGTTCATGCCATTTGTCAAGGAATTATCGGAAGCCCTGACCAGG
CATGGAGTATCTCACAAAGTAGACGATTCCTCTGGGTCAATCGGAAGGCGCTATGCCAGG
ACTGATGAGATTGGCGTGGCTTTTGGTGTCACCATTGACTTTGACACAGTGAACAAGACC
CCCCACACTGCAACTCTGAGGGACCGTGACTCAATGCGGCAGATAAGAGCAGAGATCTCT
GAGCTGCCCAGCATAGTCCAAGACCTAGCCAATGGCAACATCACATGGGCTGATGTGGAG
GCCAGGTATCCTCTGTTTGAAGGGCAAGAGACTGGTAAAAAAGAGACAATCGAGGAATGA


# Metabolic_Enzyme_16_GenBank_ID_Gene:
D30658

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_16_Locus:
7p15

# Metabolic_Enzyme_16_SNPs:
rs17159287; rs34886142; rs17159306; rs7808770; rs3886641; rs11553502; rs1049402; rs2970504; rs2529438; rs1468402; rs2709806; rs2527880; rs728539; rs12532057; rs2709778; rs2529439; rs11981106; rs2709809; rs2240401; rs11979352; rs6945035; rs722423; rs10951271; rs758000; rs10239660; rs2527878; rs2527879; rs10249885; rs6462214; rs1558064; rs10487699; rs2893390; rs10487700; rs3807632; rs10265589; rs1986756; rs13228758; rs6970807; rs17159291; rs10280491; rs2240400; rs2709772; rs16875290; rs10233132; rs13228097; rs17159273; rs17159275; rs6950015; rs11980069; rs2072236; rs17159267; rs10239537; rs11982890; rs6947982; rs17159289; rs2074779; rs11976576; rs17159279; rs17159296; rs11761080; rs2529441; rs17159280; rs2529442; rs2952804; rs6945223; rs17159272; rs2270025; rs2214837; rs11553498; rs1049399; rs11553503; rs17159262; rs35302357; rs3807633; rs35241091; rs3840589; rs34230821; rs11465024; rs35711502; rs34957085; rs34725384; rs13228094; rs2240501; rs41275991; rs34457367; rs6945546; rs10229836; rs35151755; rs34785207; rs2709771; rs34149226; rs10264469; rs6945475; rs1986757; rs3840588; rs6945586; rs41275988; rs36125163; rs35425165; rs34885661; rs13226718; rs35821025; rs2952805; rs35482863; rs34495080; rs11454228; rs13228006; rs34668775; rs2893388; rs35045679; rs2190241; rs2893389; rs4000210; rs10243040; rs10249882; rs11983525; rs12667790; rs13232935; rs16875282; rs16875285; rs1859644; rs2529437; rs38494; rs38497; rs38498; rs39739; rs4266550; rs4526262; rs6956054; rs7791663; rs7809256; rs7810227

# Metabolic_Enzyme_16_General_References:
7962006; 7753621; 7961834

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5640

# Metabolic_Enzyme_17_Name:
Glycine N-methyltransferase

# Metabolic_Enzyme_17_Synonyms:
Not Available

# Metabolic_Enzyme_17_Gene_Name:
GNMT

# Metabolic_Enzyme_17_Protein_Sequence:
>Glycine Nmethyltransferase
MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQR
VLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEANWMT
LDKDVPQSAEGGFDAVICLGNSFAHLPDCKGDQSEHRLALKNIASMVRAGGLLVIDHRNY
DHILSTGCAPPGKNIYYKSDLTKDVTTSVLIVNNKAHMVTLDYTVQVPGAGQDGSPGLSK
FRLSYYPHCLASFTELLQAAFGGKCQHSVLGDFKPYKPGQTYIPCYFIHVLKRTD

# Metabolic_Enzyme_17_Number_of_Residues:
295

# Metabolic_Enzyme_17_Molecular_Weight:
32743

# Metabolic_Enzyme_17_Theoretical_pI:
7.03

# Metabolic_Enzyme_17_GO_Classification:
Not Available

# Metabolic_Enzyme_17_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_17_Specific_Function:
Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine

# Metabolic_Enzyme_17_Pathway:
map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_17_Reaction:
S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF08242:Methyltransf_12

# Metabolic_Enzyme_17_Signals:
None

# Metabolic_Enzyme_17_Transmembrane_Regions:
None

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 2.1.1.20

# Metabolic_Enzyme_17_GenBank_ID_Protein:
8671584

# Metabolic_Enzyme_17_SwissProt_ID:
GNMT_HUMAN (Q14749)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
GNMT

# Metabolic_Enzyme_17_Geneatlas_id:
GNMT

# Metabolic_Enzyme_17_hgnc_id:
HGNC:4415

# Metabolic_Enzyme_17_PDB_ID:
1R74

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_17_Gene_Sequence:
>888 bp
ATGGTGGACAGCGTGTACCGGACCCGCTCCCTGGGGGTGGCGGCCGAAGGGCTCCCGGAC
CAGTACGCGGACGGGGAGGCGGCGCGCGTGTGGCAGCTGTATATCGGAGACACCCGCAGC
CGCACCGCCGAGTACAAGGCATGGCTGCTTGGGCTGCTGCGCCAGCACGGCTGCCAGCGG
GTGCTCGACGTAGCCTGTGGCACTGGGGTGGACTCCATTATGCTGGTGGAAGAGGGCTTC
AGTGTGACGAGTGTGGATGCCAGTGACAAGATGCTGAAGTATGCACTTAAGGAGCGCTGG
AACCGGCGGCACGAGCCCGCCTTCGACAAGTGGGTCATCGAAGAAGCCAACTGGATGACT
CTGGACAAAGATGTGCCCCAGTCAGCAGAGGGTGGCTTTGATGCTGTCATCTGCCTTGGA
AACAGTTTCGCTCACTTGCCAGACTGCAAAGGGGACCAGAGTGAGCACCGGCTGGCGCTG
AAAAACATTGCGAGCATGGTGCGGGCAGGGGGCCTACTGGTCATTGATCATCGCAACTAC
GACCACATCCTCAGTACAGGCTGTGCACCCCCAGGGAAGAACATCTACTATAAGAGTGAC
TTGACCAAGGACGTCACAACATCAGTGCTGATAGTGAACAACAAGGCCCACATGGTGACC
CTGGACTATACGGTGCAGGTGCCGGGGGCTGGCCAGGATGGCTCTCCTGGCTTGAGTAAG
TTCCGGCTCTCCTACTACCCACACTGTCTGGCATCCTTCACGGAGCTGCTCCAAGCAGCC
TTCGGAGGTAAGTGCCAGCACAGCGTCCTGGGCGACTTCAAGCCTTACAAGCCAGGCCAA
ACCTACATTCCCTGCTACTTCATCCACGTGCTCAAGAGGACAGACTGA

# Metabolic_Enzyme_17_GenBank_ID_Gene:
AF101477

# Metabolic_Enzyme_17_Chromosome_Location:
Not Available

# Metabolic_Enzyme_17_Locus:
Not Available

# Metabolic_Enzyme_17_SNPs:
Not Available

# Metabolic_Enzyme_17_General_References:
9495250; 10843803; 11810299

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
6075

# Metabolic_Enzyme_18_Name:
Glycine dehydrogenase [decarboxylating], mitochondrial precursor

# Metabolic_Enzyme_18_Synonyms:
Glycine decarboxylase; Glycine cleavage system P- protein

# Metabolic_Enzyme_18_Gene_Name:
GLDC

# Metabolic_Enzyme_18_Protein_Sequence:
>Glycine dehydrogenase decarboxylating, mitochondrial precursor
MQSCARAWGLRLGRGVGGGRRLAGGSGPCWAPRSRDSSSGGGDSAAAGASRLLERLLPRH
DDFARRHIGPGDKDQREMLQTLGLASIDELIEKTVPANIRLKRPLKMEDPVCENEILATL
HAISSKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQ
TMVCDITGLDMANASLLDEGTAAAEALQLCYRHNKRRKFLVDPRCHPQTIAVVQTRAKYT
GVLTELKLPCEMDFSGKDVSGVLFQYPDTEGKVEDFTELVERAHQSGSLACCATDLLALC
ILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVGVTRDATGKEV
YRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSHGLEHIARRVHNATLILSE
GLKRAGHQLQHDLFFDTLKIHCGCSVKEVLGRAAQRQINFRLFEDGTLGISLDETVNEKD
LDDLLWIFGCESSAELVAESMGEECRGIPGSVFKRTSPFLTHQVFNSYHSETNIVRYMKK
LENKDISLVHSMIPLGSCTMKLNSSSELAPITWKEFANIHPFVPLDQAQGYQQLFRELEK
DLCELTGHDQVCFQPNSGAQGEYAGLATIRAYLNQKGEGHRTVCLIPKSAHGTNPASAHM
AGMKIQPVEVDKYGNIDAVHLKAMVDKHKENLAAIMITYPSTNGVFEENISDVCDLIHQH
GGQVYLDGANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLAPFL
PNHPVISLKRNEDACPVGTVSAAPWGSSSILPISWAYIKMMGGKGLKQATETAILNANYM
AKRLETHYRILFRGARGYVGHEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWPVA
GTLMVEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSHW
DRPYSREVAAFPLPFVKPENKFWPTIARIDDIYGDQHLVCTCPPMEVYESPFSEQKRASS


# Metabolic_Enzyme_18_Number_of_Residues:
1020

# Metabolic_Enzyme_18_Molecular_Weight:
112714

# Metabolic_Enzyme_18_Theoretical_pI:
7.14

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
Function:  glycine dehydrogenase (decarboxylating) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
 ||
>>>
Component:  protein complex
Component:  glycine dehydrogenase complex (decarboxylating)

# Metabolic_Enzyme_18_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_18_Specific_Function:
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein

# Metabolic_Enzyme_18_Pathway:
map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_18_Reaction:
glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF02347:GDC-P

# Metabolic_Enzyme_18_Signals:
None

# Metabolic_Enzyme_18_Transmembrane_Regions:
None

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 1.4.4.2

# Metabolic_Enzyme_18_GenBank_ID_Protein:
190287

# Metabolic_Enzyme_18_SwissProt_ID:
GCSP_HUMAN (P23378)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
GLDC

# Metabolic_Enzyme_18_Geneatlas_id:
GLDC

# Metabolic_Enzyme_18_hgnc_id:
HGNC:4313

# Metabolic_Enzyme_18_PDB_ID:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_18_Gene_Sequence:
>3063 bp
ATGCAGTCCTGTGCCAGGGCGTGGGGGCTGCGCCTGGGCCGCGGGGTCGGGGGCGGCCGC
CGCCTGGCTGGGGGATCGGGGCCGTGCTGGGCGCCGCGGAGCCGGGACAGCAGCAGTGGC
GGCGGGGACAGCGCCGCGGCTGGGGCCTCGCGCCTCCTGGAGCGCCTTCTGCCCAGACAC
GACGACTTCGCTCGGAGGCACATCGGCCCTGGGGACAAAGACCAGAGAGAGATGCTGCAG
ACCTTGGGGCTGGCGAGCATTGATGAATTGATCGAGAAGACGGTCCCTGCCAACATCCGT
TTGAAAAGACCCTTGAAAATGGAAGACCCTGTTTGTGAAAATGAAATCCTTGCAACTCTG
CATGCCATTTCAAGCAAAAACCAGATCTGGAGATCGTATATTGGCATGGGCTATTATAAC
TGCTCAGTGCCACAGACGATTTTGCGGAACTTACTGGAGAACTCAGGATGGATCACCCAG
TATACTCCATACCAGCCTGAGGTGTCTCAGGGGAGGCTGGAGAGTTTACTCAACTACCAG
ACCATGGTGTGTGACATCACAGGCCTGGACATGGCCAATGCATCCCTGCTGGATGAGGGG
ACTGCAGCCGCAGAGGCACTGCAGCTGTGCTACAGACACAACAAGAGGAGGAAATTTCTC
GTTGATCCCCGTTGCCACCCACAGACAATAGCTGTTGTCCAGACTCGAGCCAAATATACT
GGAGTCCTCACTGAGCTGAAGTTACCCTGTGAAATGGACTTCAGTGGAAAAGATGTCAGT
GGAGTGTTGTTCCAGTACCCAGACACGGAGGGGAAGGTGGAAGACTTTACGGAACTCGTG
GAGAGAGCTCATCAGAGTGGGAGCCTGGCCTGCTGTGCTACTGACCTTTTAGCTTTGTGC
ATCTTGAGGCCACCTGGAGAATTTGGGGTAGACATCGCCCTGGGCAGCTCCCAGAGATTT
GGAGTGCCACTGGGCTATGGGGGACCCCATGCAGCATTTTTTGCTGTCCGAGAAAGCTTG
GTGAGAATGATGCCTGGAAGAATGGTGGGGGTAACAAGAGATGCCACTGGGAAAGAAGTG
TATCGTCTTGCTCTTCAAACCAGGGAGCAACACATTCGGAGAGACAAGGCTACCAGCAAC
ATCTGTACAGCTCAGGCCCTCTTGGCGAATATGGCTGCCATGTTTGCAATCTACCATGGT
TCCCATGGGCTGGAGCATATTGCTAGGAGGGTACATAATGCCACTTTGATTTTGTCAGAA
GGTCTCAAGCGAGCAGGGCATCAACTCCAGCATGACCTGTTCTTTGATACCTTGAAGATT
CATTGTGGCTGCTCAGTGAAGGAGGTCTTGGGCAGGGCGGCTCAGCGGCAGATCAATTTT
CGGCTTTTTGAGGATGGCACACTTGGTATTTCTCTTGATGAAACAGTCAATGAAAAAGAT
CTGGACGATTTGTTGTGGATCTTTGGTTGTGAGTCATCTGCAGAACTGGTTGCTGAAAGC
ATGGGAGAGGAGTGCAGAGGTATTCCAGGGTCTGTGTTCAAGAGGACCAGCCCGTTCCTC
ACCCATCAAGTGTTCAACAGCTACCACTCTGAAACAAACATTGTCCGGTACATGAAGAAA
CTGGAAAATAAAGACATTTCCCTTGTTCACAGCATGATTCCACTGGGATCCTGCACCATG
AAACTGAACAGTTCGTCTGAACTCGCACCTATCACATGGAAAGAATTTGCAAACATCCAC
CCCTTTGTGCCTCTGGATCAAGCTCAAGGATATCAGCAGCTTTTCCGAGAGCTTGAGAAG
GATTTGTGTGAACTCACAGGTCATGACCAGGTCTGTTTCCAGCCAAACAGCGGAGCCCAG
GGAGAATATGCTGGACTGGCCACTATCCGAGCCTACTTAAACCAGAAAGGAGAGGGGCAC
AGAACGGTTTGCCTCATTCCGAAATCAGCACATGGGACCAACCCAGCAAGTGCCCACATG
GCAGGCATGAAGATTCAGCCTGTGGAGGTGGATAAATATGGGAATATCGATGCAGTTCAC
CTCAAGGCCATGGTGGATAAGCACAAGGAGAACCTAGCAGCTATCATGATTACATACCCA
TCCACCAATGGGGTGTTTGAAGAGAACATCAGTGACGTGTGTGACCTCATCCATCAACAT
GGAGGACAGGTCTACCTAGACGGGGCAAATATGAATGCTCAGGTGGGAATCTGTCGCCCT
GGAGACTTCGGGTCTGATGTCTCGCACCTAAATCTTCACAAGACCTTCTGCATTCCCCAC
GGAGGAGGTGGTCCTGGCATGGGGCCCATCGGAGTGAAGAAACATCTCGCCCCGTTTTTG
CCCAATCATCCCGTCATTTCACTAAAGCGGAATGAGGATGCCTGTCCTGTGGGAACCGTC
AGTGCGGCCCCATGGGGCTCCAGTTCCATCTTGCCCATTTCCTGGGCTTATATCAAGATG
ATGGGAGGCAAGGGTCTTAAACAAGCCACGGAAACTGCGATATTAAATGCCAACTACATG
GCCAAGCGATTAGAAACACACTACAGAATTCTTTTCAGGGGTGCAAGAGGTTATGTGGGT
CATGAATTTATTTTGGACACGAGACCCTTCAAAAAGTCTGCAAATATTGAGGCTGTGGAT
GTGGCCAAGAGACTCCAGGATTATGGATTTCACGCCCCTACCATGTCCTGGCCTGTGGCA
GGGACCCTCATGGTGGAGCCCACTGAGTCGGAGGACAAGGCAGAGCTGGACAGATTCTGT
GATGCCATGATCAGCATTCGGCAGGAAATTGCTGACATTGAGGAGGGCCGCATCGACCCC
AGGGTCAATCCGCTGAAGATGTCTCCACACTCCCTGACCTGCGTTACATCTTCCCACTGG
GACCGGCCTTATTCCAGAGAGGTGGCAGCATTCCCACTCCCCTTCGTGAAACCAGAGAAC
AAATTCTGGCCAACGATTGCCCGGATTGATGACATATATGGAGATCAGCACCTGGTTTGT
ACCTGCCCACCCATGGAAGTTTATGAGTCTCCATTTTCTGAACAAAAGAGGGCGTCTTCT
TAG

# Metabolic_Enzyme_18_GenBank_ID_Gene:
M63635

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_18_Locus:
9p22

# Metabolic_Enzyme_18_SNPs:
rs12006005; rs12004164; rs12006003; rs2228098; rs7848919; rs1061407; rs12350734; rs2282162; rs1929930; rs2150915; rs7039182; rs2773507; rs4333664; rs2274874; rs4518719; rs10975638; rs11790612; rs2578268; rs4742213; rs10975663; rs1755617; rs1755615; rs2282161; rs6477101; rs4602948; rs1025720; rs2297443; rs2282160; rs6477096; rs7035933; rs4629927; rs7048982; rs10975662; rs1025722; rs7863517; rs7034327; rs10815443; rs6477088; rs1929933; rs4742211; rs1260460; rs7037383; rs7035481; rs7027289; rs2026972; rs7031908; rs7030133; rs7853386; rs12347506; rs7030760; rs2282159; rs6477091; rs1025721; rs11789593; rs1755608; rs4740848; rs10123810; rs4237166; rs2026973; rs10975681; rs7040427; rs4512434; rs4387027; rs4742212; rs2578267; rs4419859; rs7864644; rs11999004; rs9299034; rs10125618; rs12347456; rs968197; rs11788881; rs2026974; rs968196; rs7049056; rs7048872; rs10511461; rs12004478; rs16924678; rs4742214; rs7027507; rs11998836; rs7026782; rs12002731; rs6477095; rs2480802; rs12005397; rs17591030; rs12001457; rs7048970; rs10815450; rs7863638; rs12343253; rs4543594; rs10975630; rs10815441; rs1929931; rs10975654; rs2578269; rs10117019; rs13440229; rs2773506; rs7860255; rs2773502; rs2225519; rs1755614; rs7043546; rs934854; rs7853921; rs7870809; rs2118653; rs11792185; rs12346479; rs1821892; rs1260463; rs7859893; rs7021520; rs2297442; rs10117232; rs7019525; rs10815458; rs7022724; rs2282158; rs7873572; rs10975655; rs7023971; rs7019384; rs7036653; rs10975641; rs6477094; rs10481602; rs7021684; rs4415375; rs7021790; rs1658977; rs2578272; rs11789777; rs16924717; rs10815447; rs1755616; rs7862384; rs7035557; rs1260464; rs10441734; rs12683100; rs12683330; rs10815455; rs10815454; rs7036639; rs12350222; rs10975646; rs16924687; rs12553292; rs11999044; rs16924682; rs2578271; rs10815448; rs2578264; rs1658978; rs7867577; rs7041988; rs1755613; rs12351820; rs6477089; rs2773503; rs1755609; rs10120677; rs10975687; rs10124861; rs10465093; rs12004647; rs4740852; rs2297444; rs6477098; rs7860596; rs6477100; rs7846856; rs10975682; rs7849728; rs10815445; rs2013966; rs1755606; rs12685035; rs10815453; rs2578265; rs2578292; rs2578279; rs12346767; rs5001001; rs2438410; rs3765556; rs12353101; rs7021944; rs12349059; rs12005123; rs10975645; rs7029245; rs7049229; rs9696061; rs1269167; rs10975667; rs17499965; rs7031981; rs7863696; rs10975705; rs12683179; rs1972847; rs12000020; rs10758799; rs6477099; rs7030910; rs16924731; rs1755607; rs7873802; rs3925456; rs12003910; rs11788649; rs2578270; rs2773511; rs13298254; rs16924727; rs13290832; rs7862900; rs10815452; rs12001793; rs12352496; rs7034260; rs12003134; rs7022270; rs10758800; rs16924709; rs11999501; rs13290859; rs10975665; rs7862147; rs3765555; rs12339602; rs6477097; rs1755604; rs4742234; rs12339196; rs11790637; rs13295349; rs2578282; rs16924691; rs7865576; rs9299033; rs12686522; rs7044487; rs10975686; rs4742218; rs7048581; rs13300660; rs10975650; rs2118656; rs7876003; rs928393; rs10975677; rs10975647; rs10156472; rs10815446; rs2890722; rs3902970; rs1755603; rs12348822; rs10975691; rs2438409; rs1811943; rs1755612; rs12006559; rs3215923; rs11999777; rs10124449; rs7872165; rs10975640; rs12005777; rs12683164; rs7045613; rs13288399; rs4629926; rs2773504; rs35287966; rs10124675; rs7853916; rs4740853; rs1970081; rs3818705; rs3739653; rs12002500; rs11792739; rs10975629; rs2988415; rs7859329; rs13297368; rs10975627; rs7030179; rs1062458; rs10975674; rs28617412; rs13289273; rs12341698; rs35374927; rs3215922; rs35834773; rs3211505; rs35581717; rs34298851; rs10975668; rs12336574; rs34272160; rs7858498; rs12006519; rs2118655; rs10117821; rs34248027; rs34571237; rs34877988; rs34738320; rs35262449; rs10975642; rs34145749; rs7022241; rs4563946; rs1658953; rs28404672; rs41305657; rs36096162; rs12352917; rs7046575; rs41281771; rs10975689; rs36030536; rs10975683; rs10975706; rs7860077; rs12555181; rs35790929; rs35530935; rs4504696; rs12683915; rs35336879; rs34122393; rs34257478; rs34170195; rs35284203; rs10975669; rs12347312; rs35510890; rs41526646; rs10123952; rs13300754; rs34099847; rs34960337; rs34380343; rs12378606; rs34754822; rs34698635; rs34740127; rs13284802; rs35891256; rs35065126; rs3739652; rs35030605; rs35201927; rs34760385; rs28499127; rs34106246; rs5896157; rs10975678; rs7849131; rs12235820; rs12341267; rs34848653; rs10975643; rs7846763; rs5896159; rs12347465; rs28616100; rs11787539; rs34295613; rs13299598; rs12156494; rs2578274; rs34197434; rs1963436; rs36090288; rs36078532; rs7858290; rs13285005; rs34948145; rs34247404; rs10125015; rs10975684; rs10122606; rs41298182; rs36030937; rs12554759; rs5896154; rs10120668; rs7036856; rs28776206; rs33971598; rs34407041; rs13296487; rs10975660; rs35870984; rs12341084; rs35376178; rs10975694; rs10975672; rs7466799; rs34835975; rs12347488; rs13439901; rs34608509; rs4742210; rs35766258; rs10975688; rs10975644; rs12345729; rs10975675; rs10975631; rs2118654; rs41281773; rs2026971; rs35289176; rs28833481; rs35499280; rs10975693; rs2164953; rs35279869; rs10975671; rs34247224; rs13284797; rs34056367; rs36217518; rs4351464; rs41281769; rs2578291; rs1658945; rs7853194; rs10975703; rs2578273; rs33975877; rs12379309; rs35872509; rs35226461; rs7467529; rs35318729; rs7873092; rs7019544; rs1658976; rs35067265; rs5896155; rs35534562; rs13291163; rs34482877; rs35701567; rs34750106; rs34280433; rs35317984; rs12347503; rs35972094; rs5001002; rs7020909; rs10975676; rs28367179; rs12550994; rs35371693; rs13300114; rs2918176; rs35401419; rs28607506; rs10114495; rs10975649; rs13287502; rs13296893; rs7022864; rs10975633; rs34874616; rs34231536; rs10975704; rs7874313; rs34073615; rs12353462; rs41303229; rs1658946; rs7027957; rs13297203; rs2773505; rs2773501; rs7020315; rs12351620; rs10975685; rs1974189; rs35956237; rs4742228; rs10975707; rs7041127; rs35092612; rs11793736; rs35003488; rs35406241; rs10975670; rs10975711; rs34167394; rs41281775; rs35255073; rs28631379; rs5896156; rs7873244; rs13283770; rs5001003; rs934855; rs34789258; rs968198; rs34832180; rs13301086; rs10975656; rs34891903; rs13299772; rs5896153; rs28876374; rs12343657; rs34533996; rs36043080; rs34705959; rs2578266; rs12343658; rs34438524; rs35876829; rs35083271; rs10975637; rs35686622; rs41298176; rs28449309; rs7872145; rs34302796; rs1755605; rs10123971; rs33945262; rs7863777; rs35594551; rs7862146; rs12235825; rs7030089; rs4742230; rs10481603; rs12339217; rs12375532; rs5896160; rs2773500; rs34879516; rs10975664; rs7854679; rs12236494; rs10123259; rs35783846; rs35183251; rs2773508; rs35372321; rs10975690; rs17591465; rs7861068; rs13294720; rs7046697; rs33930898; rs34806087; rs33914197; rs34551978; rs35101912; rs35734437; rs5896161; rs10975712; rs2578278; rs7023606; rs5896163; rs13283857; rs5896162; rs2773509; rs10975626; rs35974452; rs35458135; rs13297829; rs34080828; rs7465961; rs12377131; rs35216150; rs34941660; rs34738970; rs10815461; rs10975714; rs11787871; rs11795213; rs11999442; rs12005104; rs12344555; rs12348313; rs12350309; rs12352265; rs12353287; rs12552173; rs1547256; rs1547257; rs1547258; rs16924650; rs17499514; rs2578277; rs2578283; rs2578284; rs2578286; rs2988418; rs34267359; rs34775285; rs4742231; rs4742235; rs7030186; rs7031325; rs7872937

# Metabolic_Enzyme_18_General_References:
1996985; 1993704; 1634607; 11286506; 11592811

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5428

# Metabolic_Enzyme_19_Name:
Glutathione reductase, mitochondrial precursor

# Metabolic_Enzyme_19_Synonyms:
GR; GRase

# Metabolic_Enzyme_19_Gene_Name:
GSR

# Metabolic_Enzyme_19_Protein_Sequence:
>Glutathione reductase, mitochondrial precursor
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK
TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD
EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR

# Metabolic_Enzyme_19_Number_of_Residues:
522

# Metabolic_Enzyme_19_Molecular_Weight:
56258

# Metabolic_Enzyme_19_Theoretical_pI:
8.66

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  disulfide oxidoreductase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  FAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  transporter activity
Function:  electron transporter activity
Function:  glutathione-disulfide reductase activity
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  electron transport
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  cofactor metabolism
Process:  coenzyme metabolism
Process:  glutathione metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_19_General_Function:
RNA processing and modification 

# Metabolic_Enzyme_19_Specific_Function:
Maintains high levels of reduced glutathione in the cytosol

# Metabolic_Enzyme_19_Pathway:
map00251  Glutamate metabolism;
 map00480  Glutathione metabolism

# Metabolic_Enzyme_19_Reaction:
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF00070:Pyr_redox;
PF07992:Pyr_redox_2;
PF02852:Pyr_redox_dim

# Metabolic_Enzyme_19_Signals:
1-37

# Metabolic_Enzyme_19_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 1.8.1.7

# Metabolic_Enzyme_19_GenBank_ID_Protein:
31825

# Metabolic_Enzyme_19_SwissProt_ID:
GSHR_HUMAN (P00390)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
GSR

# Metabolic_Enzyme_19_Geneatlas_id:
GSR

# Metabolic_Enzyme_19_hgnc_id:
HGNC:4623

# Metabolic_Enzyme_19_PDB_ID:
1BWC

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Mitochondrion. Cytoplasm

# Metabolic_Enzyme_19_Gene_Sequence:
>1440 bp
ATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGCGCCGTGGCC
TCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCG
GCCGAGCTGGGTGCCAGGGCCGCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCGTG
AATGTTGGATGTGTACCCAAAAAGGTAATGTGGAACACAGCTGTCCACTCTGAATTCATG
CATGATCATGCTGATTATGGCTTTCCAAGTTGTGAGGGTAAATTCAATTGGCGTGTTATT
AAGGAAAAGCGGGATGCCTATGTGAGCCGCCTGAATGCCATCTATCAAAACAATCTCACC
AAGTCCCATATAGAAATCATCCGTGGCCATGCAGCCTTCACGAGTGATCCCAAGCCCACA
ATAGAGGTCAGTGGGAAAAAGTACACCGCCCCACACATCCTGATCGCCACAGGTGGTATG
CCCTCCACCCCTCATGAGAGCCAGATCCCCGGTGCCAGCTTAGGAATAACCAGCGATGGA
TTTTTTCAGCTGGAAGAATTGCCCGGCCGCAGCGTCATTGTTGGTGCAGGTTACATTGCT
GTGGAGATGGCAGGGATCCTGTCAGCCCTGGGTTCTAAGACATCACTGATGATACGGCAT
GATAAGGTACTTAGAAGTTTTGATTCAATGATCAGCACCAACTGCACGGAGGAGCTGGAG
AACGCTGGCGTGGAGGTGCTGAAGTTCTCCCAGGTCAAGGAGGTTAAAAAGACTTTGTCG
GGCTTGGAAGTCAGCATGGTTACTGCAGTTCCCGGTAGGCTACCAGTCATGACCATGATT
CCAGATGTTGACTGCCTGCTCTGGGCCATTGGGCGGGTCCCGAATACCAAGGACCTGAGT
TTAAACAAACTGGGGATTCAAACCGATGACAAGGGTCATATCATCGTAGACGAATTCCAG
AATACCAACGTCAAAGGCATCTATGCAGTTGGGGATGTATGTGGAAAAGCTCTTCTTACT
CCAGTTGCAATAGCTGCTGGCCGAAAACTTGCCCATCGACTTTTTGAATATAAGGAAGAT
TCCAAATTAGATTATAACAACATCCCAACTGTGGTCTTCAGCCACCCCCCTATTGGGACA
GTGGGACTCACGGAAGATGAAGCCATTCATAAATATGGAATAGAAAATGTGAAGACCTAT
TCAACGAGCTTTACCCCGATGTATCACGCAGTTACCAAAAGGAAAACAAAATGTGTGATG
AAAATGGTCTGTGCTAACAAGGAAGAAAAGGTGGTTGGGATCCATATGCAGGGACTTGGG
TGTGATGAAATGCTGCAGGGTTTTGCTGTTGCAGTGAAGATGGGAGCAACGAAGGCAGAC
TTTGACAACACAGTCGCCATTCACCCTACCTCTTCAGAAGAGCTGGTCACACTTCGTTGA


# Metabolic_Enzyme_19_GenBank_ID_Gene:
X15722

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_19_Locus:
8p21.1

# Metabolic_Enzyme_19_SNPs:
rs8190955; rs2020916; rs8190976; rs2280854; rs2280855; rs8191005; rs8190881; rs1554991; rs8191039; rs1138054; rs8191040; rs2911670; rs2551696; rs2551715; rs2253409; rs2911669; rs2739008; rs2161850; rs10088455; rs2978295; rs8190896; rs2551702; rs7818511; rs1125853; rs10094209; rs3779647; rs2250192; rs2738973; rs2978663; rs2161849; rs8190927; rs2343688; rs8190983; rs8191025; rs2551724; rs2472219; rs3779648; rs3757918; rs2978297; rs8190966; rs2551708; rs2739002; rs2280857; rs2251780; rs8190986; rs2978670; rs8190887; rs2978667; rs1465478; rs8190917; rs8190894; rs8191003; rs2911674; rs8190898; rs2551710; rs2551698; rs4628224; rs2551707; rs2911676; rs8190968; rs8190943; rs2280856; rs3757917; rs8190892; rs8190996; rs2956007; rs8191030; rs2739004; rs7832572; rs6996579; rs8190890; rs8190907; rs2880679; rs2911673; rs8190886; rs7827120; rs7007803; rs16877292; rs8191019; rs2978298; rs8190987; rs2113525; rs2978662; rs8190893; rs2978296; rs3926402; rs2551732; rs17557435; rs11992338; rs8190948; rs8190945; rs2978669; rs2551706; rs2113524; rs11992081; rs8191038; rs8190930; rs12678167; rs8190919; rs8190891; rs8190910; rs8190904; rs8190969; rs7817288; rs8190925; rs8191031; rs2472220; rs2955993; rs2911668; rs8191023; rs8190923; rs8190906; rs8190900; rs8191018; rs2978303; rs12543353; rs8190922; rs8190994; rs2467539; rs8190949; rs2978665; rs889926; rs8190889; rs8191016; rs8191029; rs8190972; rs8191008; rs8191027; rs2739012; rs8190981; rs16877293; rs2249404; rs8191022; rs11774927; rs8191035; rs8190992; rs1318983; rs8190991; rs2978671; rs2911678; rs2551700; rs8190933; rs4377922; rs8190911; rs8190973; rs8191028; rs8190946; rs8191017; rs8190914; rs2978666; rs2551699; rs2739011; rs8190967; rs8190924; rs8191033; rs8190954; rs8190918; rs13259611; rs8190908; rs8190901; rs8190975; rs8190944; rs8191006; rs2551697; rs8191010; rs2472221; rs8191026; rs8190902; rs2911675; rs2911672; rs8190895; rs13279565; rs8190937; rs8191013; rs8190888; rs8190988; rs1465479; rs2161848; rs10088303; rs2467538; rs8190897; rs8190951; rs8190939; rs8191037; rs8190970; rs8191036; rs2551726; rs1465477; rs8191009; rs8190899; rs8190926; rs8190958; rs2739013; rs8190982; rs4733505; rs3594; rs1002149; rs2280853; rs2280852; rs1138107; rs2955996; rs1973874; rs8190877; rs8191042; rs1968278; rs1985176; rs8190878; rs8191043; rs8190997; rs3180947; rs34855738; rs3180950; rs8190884; rs8191004; rs3180949; rs3180948; rs8190883; rs11552962; rs926171; rs2551733; rs8191041; rs8190882; rs35768151; rs1138052; rs926172; rs926170; rs10216724; rs35555269; rs13251135; rs28503477; rs8190977; rs8190999; rs8191020; rs1318334; rs8190913; rs28653003; rs7011849; rs28551481; rs8190984; rs2739010; rs2738994; rs2739000; rs8190990; rs2551716; rs8191007; rs34877158; rs2956006; rs8190921; rs2738984; rs2738981; rs2472215; rs8190950; rs11461103; rs2978661; rs2551731; rs10608990; rs3077097; rs11781803; rs2955990; rs34421060; rs961267; rs28659928; rs2467548; rs8190963; rs28510299; rs10635942; rs28452359; rs2738978; rs2551720; rs2467545; rs36079387; rs909351; rs8190915; rs8190957; rs10679532; rs35922361; rs35385906; rs12681084; rs2551718; rs11316943; rs34274967; rs8190885; rs8191015; rs3779646; rs8190964; rs2472217; rs2738986; rs2551729; rs10649702; rs2472212; rs34724930; rs13253409; rs2738982; rs2738992; rs8190932; rs2978302; rs2303343; rs2551722; rs11386943; rs10090296; rs8190974; rs2978290; rs8190941; rs8191011; rs1473673; rs2738990; rs7831264; rs8190971; rs2738983; rs34353898; rs8190965; rs7007798; rs35029937; rs34815510; rs2472214; rs1965590; rs2472218; rs9773264; rs34205548; rs34380214; rs2738998; rs7830949; rs2955995; rs2551727; rs2467547; rs34342136; rs28548706; rs2467543; rs2738975; rs8190934; rs7461403; rs28452748; rs8191024; rs34774713; rs11386939; rs35464878; rs34789848; rs8190931; rs10715710; rs34873265; rs11299063; rs11364879; rs2472216; rs35456447; rs2467537; rs2551721; rs8190998; rs28414905; rs8190952; rs34476341; rs2738996; rs2738976; rs36213901; rs33969377; rs2551704; rs2911679; rs36066856; rs36069113; rs2956005; rs2551717; rs34704939; rs8190912; rs8190903; rs8191014; rs2551725; rs8191001; rs1599947; rs8190936; rs28649502; rs5890532; rs1465102; rs8190905; rs2551711; rs2738985; rs28489542; rs2467544; rs2955991; rs7816217; rs2738993; rs35594378; rs2739007; rs2551730; rs2467549; rs8190962; rs2738995; rs35866628; rs6982734; rs36063576; rs8190938; rs2738979; rs2551719; rs3110091; rs2911671; rs2739009; rs11785352; rs35320606; rs34590858; rs34423117; rs36035324; rs35272936; rs10584054; rs34649346; rs2551709; rs34123148; rs8190985; rs35944160; rs2738987; rs35345657; rs8190920; rs16877277; rs34180062; rs35356298; rs13258442; rs2551723; rs35823823; rs2978301; rs8190935; rs10102510; rs34885609; rs35706621; rs28707724; rs10106746; rs8191032; rs2551703; rs8190989; rs2739001; rs13268496; rs2551712; rs2738989; rs33969608; rs2955994; rs34889409; rs28641651; rs8190961; rs34676475; rs34141675; rs2738972; rs2738988; rs2738999; rs35052620; rs8190953; rs8191002; rs34390863; rs35321123; rs909352; rs35206861; rs2343687; rs28517564; rs8191012; rs8190916; rs8190980; rs8191034; rs16877266; rs2738974; rs2739003; rs8190940; rs34302748; rs2738980; rs8190956; rs8191021; rs2551705; rs2956004; rs2978305; rs11347956; rs2911677; rs2978664; rs2551714; rs2738997; rs2467546; rs8191000; rs2738991; rs35132121; rs7461402; rs2738977; rs36076894; rs8190979; rs5890533; rs10704685; rs2551701; rs1318333; rs35866797; rs8190942; rs10629215; rs8190929; rs2467536; rs2472213; rs7012340; rs12547563; rs13250209; rs28532763; rs2551735; rs11552960; rs11552964; rs14203; rs34396322; rs2551738; rs3201906; rs36124241; rs7357427; rs8190880; rs11552958; rs1138117; rs2911680; rs1973873; rs8190879; rs2955998; rs2551734; rs10634282; rs11552957; rs11552961; rs1138092; rs11552955; rs34431739; rs10558838; rs10652997; rs2551736; rs2551739; rs1138089; rs11552954; rs2551737; rs35938308; rs2978668; rs8190876; rs34067868; rs10283288; rs11986256; rs12541868; rs13249468; rs2161847; rs2978304; rs6987913

# Metabolic_Enzyme_19_General_References:
2185014; 10708558; 7060551; 923580; 7334521; 3656429; 8626496; 9174360; 9546215

# Metabolic_Enzyme_19_References:
16895798; 17069995; 17092368

# Metabolic_Enzyme_20_ID:
5514

# Metabolic_Enzyme_20_Name:
Myeloperoxidase precursor

# Metabolic_Enzyme_20_Synonyms:
MPO[Contains: 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain]

# Metabolic_Enzyme_20_Gene_Name:
MPO

# Metabolic_Enzyme_20_Protein_Sequence:
>Myeloperoxidase precursor
MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS
LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH
VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC
NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD
QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND
PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL
GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL
REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR
SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE
GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN
AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL
LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS
NSYPRDFVNCSTLPALNLASWREAS

# Metabolic_Enzyme_20_Number_of_Residues:
745

# Metabolic_Enzyme_20_Molecular_Weight:
83870

# Metabolic_Enzyme_20_Theoretical_pI:
9.14

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_20_General_Function:
Not Available

# Metabolic_Enzyme_20_Specific_Function:
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity

# Metabolic_Enzyme_20_Pathway:
map00360  Phenylalanine metabolism;
 map00590  Prostaglandin and leukotriene metabolism;
 map00680  Methane metabolism;
 map00940  Stilbene, coumarine and lignin biosynthesis

# Metabolic_Enzyme_20_Reaction:
donor + H2O2 = oxidized donor + 2 H2O

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF03098:An_peroxidase

# Metabolic_Enzyme_20_Signals:
None

# Metabolic_Enzyme_20_Transmembrane_Regions:
None

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 1.11.1.7

# Metabolic_Enzyme_20_GenBank_ID_Protein:
189040

# Metabolic_Enzyme_20_SwissProt_ID:
PERM_HUMAN (P05164)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
MPO

# Metabolic_Enzyme_20_Geneatlas_id:
MPO

# Metabolic_Enzyme_20_hgnc_id:
HGNC:7218

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_20_Gene_Sequence:
>2238 bp
ATGGGGGTTCCCTTCTTCTCTTCTCTCAGATGCATGGTGGACTTAGGACCTTGCTGGGCT
GGGGGTCTCACTGCAGAGATGAAGCTGCTTCTGGCCCTAGCAGGGCTCCTGGCCATTCTG
GCCACGCCCCAGCCCTCTGAAGGTGCTGCTCCAGCTGTCCTGGGGGAGGTGGACACCTCG
TTGGTGCTGAGCTCCATGGAGGAGGCCAAGCAGCTGGTGGACAAGGCCTACAAGGAGCGG
CGGGAAAGCATCAAGCAGCGGCTTCGCAGCGGCTCAGCCAGCCCCATGGAACTCCTATCC
TACTTCAAGCAGCCGGTGGCAGCCACCAGGACGGCGGTGAGGGCCGCTGACTACCTGCAC
GTGGCTCTAGACCTGCTGGAGAGGAAGCTGCGGTCCCTGTGGCGAAGGCCATTCAATGTC
ACTGATGTGCTGACGCCCGCCCAGCTGAATGTGTTGTCCAAGTCAAGCGGCTGCGCCTAC
CAGGACGTGGGGGTGACTTGCCCGGAGCAGGACAAATACCGCACCATCACCGGGATGTGC
AACAACAGACGCAGCCCCACGCTGGGGGCCTCCAACCGTGCCTTTGTGCGCTGGCTGCCG
GCGGAGTATGAGGACGGCTTCTCTCTTCCCTACGGCTGGACGCCCGGGGTCAAGCGCAAC
GGCTTCCCGGTGGCTCTGGCTCGCGCGGTCTCCAACGAGATCGTGCGCTTCCCCACTGAT
CAGCTGACTCCGGACCAGGAGCGCTCACTCATGTTCATGCAATGGGGCCAGCTGTTGGAC
CACGACCTCGACTTCACCCCTGAGCCGGCCGCCCGGGCCTCCTTCGTCACTGGCGTCAAC
TGCGAGACCAGCTGCGTTCAGCAGCCGCCCTGCTTCCCGCTCAAGATCCCGCCCAATGAC
CCCCGCATCAAGAACCAAGCCGACTGCATCCCGTTCTTCCGCTCCTGCCCGGCTTGCCCC
GGGAGCAACATCACCATCCGCAACCAGATCAACGCGCTCACTTCCTTCGTGGACGCCAGC
ATGGTGTACGGCAGCGAGGAGCCCCTGGCCAGGAACCTGCGCAACATGTCCAACCAGCTG
GGGCTGCTGGCCGTCAACCAGCGCTTCCAAGACAACGGCCGGGCCCTGCTGCCCTTTGAC
AACCTGCACGATGACCCCTGTCTCCTCACCAACCGCTCAGCGCGCATCCCCTGCTTCCTG
GCAGGGGACACCCGTTCCAGTGAGATGCCCGAGCTCACCTCCATGCACACCCTCTTACTT
CGGGAGCACAACCGGCTGGCCACAGAGCTCAAGAGCCTGAACCCTAGGTGGGATGGGGAG
AGGCTCTACCAGGAAGCCCGGAAGATCGTGGGGGCCATGGTCCAGATCATCACTTACCGG
GACTACCTGCCCCTGGTGCTGGGGCCAACGGCCATGAGGAAGTACCTGCCCACGTACCGT
TCCTACAATGACTCAGTGGACCCACGCATCGCCAACGTCTTCACCAATGCCTTCCGCTAC
GGCCACACCCTCATCCAACCCTTCATGTTCCGCCTGGACAATCGGTACCAGCCCATGGAA
CCCAACCCCCGTGTCCCCCTCAGCAGGGTCTTTTTTGCCTCCTGGAGGGTCGTGCTGGAA
GGTGGCATTGACCCCATCCTCCGGGGCCTCATGGCCACCCCTGCCAAGCTGAATCGTCAG
AACCAAATTGCAGTGGATGAGATCCGGGAGCGATTGTTTGAGCAGGTCATGAGGATTGGG
CTGGACCTGCCTGCTCTGAACATGCAGCGCAGCAGGGACCACGGCCTCCCAGGATACAAT
GCCTGGAGGCGCTTCTGTGGGCTCCCGCAGCCTGAAACTGTGGGCCAGCTGGGCACGGTG
CTGAGGAACCTGAAATTGGCGAGGAAACTGATGGAGCAGTATGGCACGCCCAACAACATC
GACATCTGGATGGGCGGCGTGTCCGAGCCTCTGAAGCGCAAAGGCCGCGTGGGCCCACTC
CTCGCCTGCATCATCGGTACCCAGTTCAGGAAGCTCCGGGATGGTGATCGGTTTTGGTGG
GAGAACGAGGGTGTGTTCAGCATGCAGCAGCGACAGGCCCTGGCCCAGATCTCATTGCCC
CGGATCATCTGCGACAACACAGGCATCACCACCGTGTCTAAGAACAACATCTTCATGTCC
AACTCATATCCCCGGGACTTTGTCAACTGCAGTACACTTCCTGCATTGAACCTGGCTTCC
TGGAGGGAAGCCTCCTAG

# Metabolic_Enzyme_20_GenBank_ID_Gene:
J02694

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_20_Locus:
17q23.1

# Metabolic_Enzyme_20_SNPs:
rs7208693; rs2759; rs28730835; rs35314437; rs34628871; rs6503857; rs2856857; rs28396732; rs2071409; rs8067377; rs8082134; rs34506259; rs34704261; rs35921530; rs35840794; rs34028830; rs35087219; rs34376256; rs34212101; rs35400724; rs35112109; rs11575868; rs34471705; rs34914394; rs34673822; rs11649901; rs916115; rs35709273; rs7220117; rs8079006; rs2243828; rs2107545; rs2243827; rs8178426; rs2333227; rs12601419; rs34539862; rs34070619; rs34097845; rs34565045; rs8178428; rs35702888; rs35670089; rs2856856; rs28730837; rs35755750; rs2856855; rs35897051; rs35352616; rs8073898; rs11555567; rs34738107; rs11575867; rs2856859; rs2856858; rs2526363; rs11489012; rs2526362; rs2856852; rs34108145; rs28730838; rs11489013; rs2526364; rs12939070; rs34646152; rs12939069; rs11659055; rs34496983; rs36015586; rs35966215; rs35550002; rs36000892; rs35977697; rs2856864; rs34802326; rs8081735; rs2856861; rs11272526; rs34685535; rs2107546; rs34151601; rs36049426; rs916116; rs2526366; rs34341256; rs35614168; rs2856863; rs2856860; rs2526365; rs35830722; rs35286509; rs34841676; rs2856865; rs35922881; rs35369873; rs34432014; rs34576380; rs8178425; rs35412618; rs35433825; rs34240282; rs916114; rs34534274; rs2856854; rs34721594; rs35619750; rs8178429; rs2856853; rs8178424; rs8178427; rs34626646; rs11650865; rs12452417; rs12453852; rs12949848; rs16942910; rs2856862; rs34853811; rs3744104; rs4401102; rs8178373; rs8178375; rs8178378; rs8178380; rs8178381; rs8178384; rs8178386; rs8178387; rs8178392; rs8178395; rs8178398; rs8178404; rs8178405; rs8178406; rs8178407; rs8178409; rs8178410; rs8178412; rs8178415; rs8178416; rs8178417; rs8178418

# Metabolic_Enzyme_20_General_References:
3029127; 2444596; 3031585; 2552418; 3654979; 2903767; 8383257; 8390465; 2884926; 2154223; 10766826; 7840679; 11705390; 8142659; 7904599; 8621627; 9637725; 9354683

# Metabolic_Enzyme_20_References:
16793227; 16841962

# Metabolic_Enzyme_21_ID:
6105

# Metabolic_Enzyme_21_Name:
Glutathione S-transferase A2

# Metabolic_Enzyme_21_Synonyms:
GTH2; HA subunit 2; GST- gamma; GSTA2-2; GST class-alpha member 2

# Metabolic_Enzyme_21_Gene_Name:
GSTA2

# Metabolic_Enzyme_21_Protein_Sequence:
>Glutathione Stransferase A2
MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKEKALIDMYIEGIADLGEMILLLPFSQPEEQDAK
LALIQEKTKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEESRKIFRF

# Metabolic_Enzyme_21_Number_of_Residues:
222

# Metabolic_Enzyme_21_Molecular_Weight:
25664

# Metabolic_Enzyme_21_Theoretical_pI:
9.07

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  glutathione transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Not Available

# Metabolic_Enzyme_21_Specific_Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

# Metabolic_Enzyme_21_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_21_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Metabolic_Enzyme_21_Signals:
None

# Metabolic_Enzyme_21_Transmembrane_Regions:
None

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_21_GenBank_ID_Protein:
306811

# Metabolic_Enzyme_21_SwissProt_ID:
GSTA2_HUMAN (P09210)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
GSTA2

# Metabolic_Enzyme_21_Geneatlas_id:
GSTA2

# Metabolic_Enzyme_21_hgnc_id:
HGNC:4627

# Metabolic_Enzyme_21_PDB_ID:
1AGS

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_21_Gene_Sequence:
>669 bp
ATGGCAGAGAAGCCCAAGCTCCACTACTCCAATATACGGGGCAGAATGGAGTCCATCCGG
TGGCTCCTGGCTGCAGCTGGAGTAGAGTTTGAAGAGAAATTTATAAAATCTGCAGAAGAT
TTGGACAAGTTAAGAAATGATGGATATTTGATGTTCCAGCAAGTGCCAATGGTTGAGATT
GATGGGATGAAGCTGGTGCAGACCAGAGCCATTCTCAACTACATTGCCAGCAAATACAAC
CTCTATGGGAAAGACATAAAGGAGAAAGCCCTGATTGATATGTATATAGAAGGTATAGCA
GATTTGGGTGAAATGATCCTTCTTCTGCCCTTTACTCAACCTGAGGAACAAGATGCCAAG
CTTGCCTTGATCCAAGAGAAAACAAAAAATCGCTACTTCCCTGCCTTTGAAAAAGTCTTA
AAGAGCCACGGACAAGACTACCTTGTTGGCAACAAGCTGAGCCGGGCTGACATTCACCTG
GTGGAACTTCTCTACTACGTGGAAGAGCTTGACTCTAGCCTTATTTCCAGCTTCCCTCTG
CTGAAGGCCCTGAAAACCAGAATCAGTAACCTGCCCACAGTGAAGAAGTTTCTACAGCCT
GGCAGCCCAAGGAAGCCTCCCATGGATGAGAAATCTTTAGAAGAATCAAGGAAGATTTTC
AGGTTTTAA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
M16594

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_21_Locus:
6p12.1

# Metabolic_Enzyme_21_SNPs:
Not Available

# Metabolic_Enzyme_21_General_References:
3036131; 1329668; 1497629; 14574404; 8431482; 2604726; 11668220

# Metabolic_Enzyme_21_References:
16806198; 16807751; 16866185; 17098582

# Metabolic_Enzyme_22_ID:
5430

# Metabolic_Enzyme_22_Name:
Heme oxygenase 1

# Metabolic_Enzyme_22_Synonyms:
HO-1

# Metabolic_Enzyme_22_Gene_Name:
HMOX1

# Metabolic_Enzyme_22_Protein_Sequence:
>Heme oxygenase 1
MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVA
LEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHE
VGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQ
LYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRA
SNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM

# Metabolic_Enzyme_22_Number_of_Residues:
288

# Metabolic_Enzyme_22_Molecular_Weight:
32819

# Metabolic_Enzyme_22_Theoretical_pI:
8.68

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  heme oxygenase (decyclizing) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  heterocycle metabolism
Process:  porphyrin metabolism
Process:  heme metabolism
Process:  heme oxidation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Not Available

# Metabolic_Enzyme_22_Specific_Function:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed

# Metabolic_Enzyme_22_Pathway:
map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_22_Reaction:
heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF01126:Heme_oxygenase

# Metabolic_Enzyme_22_Signals:
None

# Metabolic_Enzyme_22_Transmembrane_Regions:
265-287

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 1.14.99.3

# Metabolic_Enzyme_22_GenBank_ID_Protein:
35173

# Metabolic_Enzyme_22_SwissProt_ID:
HMOX1_HUMAN (P09601)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
HMOX1

# Metabolic_Enzyme_22_Geneatlas_id:
HMOX1

# Metabolic_Enzyme_22_hgnc_id:
HGNC:5013

# Metabolic_Enzyme_22_PDB_ID:
1T5P

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Microsome

# Metabolic_Enzyme_22_Gene_Sequence:
>867 bp
ATGGAGCGTCCGCAACCCGACAGCATGCCCCAGGATTTGTCAGAGGCCCTGAAGGAGGCC
ACCAAGGAGGTGCACACCCAGGCAGAGAATGCTGAGTTCATGAGGAACTTTCAGAAGGGC
CAGGTGACCCGAGACGGCTTCAAGCTGGTGATGGCCTCCCTGTACCACATCTATGTGGCC
CTGGAGGAGGAGATTGAGCGCAACAAGGAGAGCCCAGTCTTCGCCCCTGTCTACTTCCCA
GAAGAGCTGCACCGCAAGGCTGCCCTGGAGCAGGACCTGGCCTTCTGGTACGGGCCCCGC
TGGCAGGAGGTCATCCCCTACACACCAGCCATGCAGCGCTATGTGAAGCGGCTCCACGAG
GTGGGGCGCACAGAGCCCGAGCTGCTGGTGGCCCACGCCTACACCCGCTACCTGGGTGAC
CTGTCTGGGGGCCAGGTGCTCAAAAAGATTGCCCAGAAAGCCCTGGACCTGCCCAGCTCT
GGCGAGGGCCTGGCCTTCTTCACCTTCCCCAACATTGCCAGTGCCACCAAGTTCAAGCAG
CTCTACCGCTCCCGCATGAACTCCCTGGAGATGACTCCCGCAGTCAGGCAGAGGGTGATA
GAAGAGGCCAAGACTGCGTTCCTGCTCAACATCCAGCTCTTTGAGGAGTTGCAGGAGCTG
CTGACCCATGACACCAAGGACCAGAGCCCCTCACGGGCACCAGGGCTTCGCCAGCGGGCC
AGCAACAAAGTGCAAGATTCTGCCCCCGTGGAGACTCCCAGAGGGAAGCCCCCACTCAAC
ACCCGCTCCCAGGCTCCGCTTCTCCGATGGGTCCTTACACTCAGCTTTCTGGTGGCGACA
GTTGCTGTAGGGCTTTATGCCATGTGA

# Metabolic_Enzyme_22_GenBank_ID_Gene:
X06985

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_22_Locus:
22q12|22q13.1

# Metabolic_Enzyme_22_SNPs:
rs2071747; rs9282702; rs5755713; rs11555832; rs9282701; rs8139532; rs8140370; rs5755720; rs5999815; rs8140669; rs11912889; rs6518952; rs9306300; rs5755719; rs3216831; rs9610292; rs5755718; rs2071748; rs17885185; rs5755717; rs2285112; rs5995100; rs2269533; rs11913097; rs5995099; rs17886055; rs16995662; rs5995097; rs7285877; rs2071749; rs2269534; rs17885522; rs12160711; rs17881086; rs5999816; rs17880614; rs2413346; rs4820192; rs8142390; rs17882597; rs17879082; rs5995098; rs9306301; rs5999814; rs9610291; rs9607267; rs5755716; rs17879606; rs11913209; rs17885902; rs17883018; rs5995101; rs9622194; rs17878790; rs17880294; rs17881147; rs17885925; rs2003038; rs17882565; rs2071746; rs9619536; rs3761439; rs17880288; rs12160039; rs17879895; rs5755712; rs17883752; rs9282700; rs35980144; rs11555830; rs11912348; rs17880056; rs5755721; rs36019273; rs35703925; rs36017314; rs35777199; rs5755715; rs17884268; rs13053677; rs17885296; rs12169444; rs12483783; rs17885538; rs28691814; rs9622192; rs12169485; rs35360540; rs17878771; rs34204969; rs35400739; rs13053402; rs9622193; rs17883936; rs34918147; rs34345283; rs17879027; rs9619539; rs9622191; rs10628026; rs12628401; rs17884230; rs34867836; rs13054865; rs13058638; rs17880184; rs5750104; rs36054326; rs35427263; rs9610290; rs3074372; rs35622428; rs9619534; rs35071398; rs5999811; rs5999813; rs5999810; rs9619537; rs9619535; rs34824930; rs13057211; rs5999812; rs17879594; rs12159977; rs1078979; rs12168789; rs12170872; rs2307334; rs2307335; rs2307337; rs3761438; rs4603883; rs4645726; rs4645729; rs4645731; rs4645741; rs4645742; rs4645746; rs4645747; rs5755722; rs5995096; rs5999817; rs5999819; rs713618; rs713688; rs713873; rs735266; rs735267; rs737777; rs743811; rs743813; rs743815; rs9306299; rs9619540

# Metabolic_Enzyme_22_General_References:
3345742; 10591208; 2911585; 2537723; 10467099

# Metabolic_Enzyme_22_References:
16982036

# Metabolic_Enzyme_23_ID:
8510

# Metabolic_Enzyme_23_Name:
Peroxiredoxin-1

# Metabolic_Enzyme_23_Synonyms:
Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2; Proliferation-associated gene protein; PAG; Natural killer cell-enhancing factor A; NKEF-A

# Metabolic_Enzyme_23_Gene_Name:
PRDX1

# Metabolic_Enzyme_23_Protein_Sequence:
>Peroxiredoxin1
MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFS
DRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLK
ADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPG
SDTIKPDVQKSKEYFSKQK

# Metabolic_Enzyme_23_Number_of_Residues:
199

# Metabolic_Enzyme_23_Molecular_Weight:
22111

# Metabolic_Enzyme_23_Theoretical_pI:
8.31

# Metabolic_Enzyme_23_GO_Classification:
Not Available

# Metabolic_Enzyme_23_General_Function:
Posttranslational modification, protein turnover, chaperones

# Metabolic_Enzyme_23_Specific_Function:
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)

# Metabolic_Enzyme_23_Pathway:
Not Available

# Metabolic_Enzyme_23_Reaction:
2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF00578:AhpC-TSA

# Metabolic_Enzyme_23_Signals:
Not Available

# Metabolic_Enzyme_23_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 1.11.1.15

# Metabolic_Enzyme_23_GenBank_ID_Protein:
287641

# Metabolic_Enzyme_23_SwissProt_ID:
PRDX1_HUMAN (Q06830)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
PRDX1

# Metabolic_Enzyme_23_Geneatlas_id:
PRDX1

# Metabolic_Enzyme_23_hgnc_id:
HGNC:9352

# Metabolic_Enzyme_23_PDB_ID:
1QQ2

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Metabolic_Enzyme_23_Gene_Sequence:
>600 bp
ATGTCTTCAGGAAATGCTAAAATTGGGCACCCTGCCCCCAACTTCAAAGCCACAGCTGTT
ATGCCAGATGGTCAGTTTAAAGATATCAGCCTGTCTGACTACAAAGGAAAATATGTTGTG
TTCTTCTTTTACCCTCTTGACTTCACCTTTGTGTGCCCCACGGAGATCATTGCTTTCAGT
GATAGGGCAGAAGAATTTAAGAAACTCAACTGCCAAGTGATTGGTGCTTCTGTGGATTCT
CACTTCTGTCATCTAGCATGGGTCAATACACCTAAGAAACAAGGAGGACTGGGACCCATG
AACATTCCTTTGGTATCAGACCCGAAGCGCACCATTGCTCAGGATTATGGGGTCTTAAAG
GCTGATGAAGGCATCTCGTTCAGGGGCCTTTTTATCATTGATGATAAGGGTATTCTTCGG
CAGATCACTGTAAATGACCTCCCTGTTGGCCGCTCTGTGGATGAGACTTTGAGACTAGTT
CAGGCCTTCCAGTTCACTGACAAACATGGGGAAGTGTGCCCAGCTGGCTGGAAACCTGGC
AGTGATACCATCAAGCCTGATGTCCAAAAGAGCAAAGAATATTTCTCCAAGCAGAAGTGA


# Metabolic_Enzyme_23_GenBank_ID_Gene:
X67951

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_23_Locus:
1p34.1

# Metabolic_Enzyme_23_SNPs:
rs5015340; rs4660867; rs2883968; rs4660868; rs2152077; rs6688424; rs34857974; rs11211130; rs6677135; rs6664588; rs6688516; rs17522918; rs35092140; rs34181355; rs34426720; rs34242105; rs34673142; rs35708671; rs34282156; rs4633317; rs2065708; rs6699702; rs2356559; rs6671347; rs4660306; rs7412911; rs6664869; rs6667191; rs2356560; rs10736426; rs2356561; rs11582118; rs11211129; rs1855621; rs16832559; rs16832557; rs35887620; rs35550669; rs34968310; rs35808563; rs7516006; rs35537214; rs35220536; rs35635144; rs4660866; rs35755479; rs35286958; rs35103566; rs4233498; rs12749658; rs36053912; rs34965970; rs11211127; rs713358; rs7534467; rs12133294; rs36088602; rs2077808; rs11544929; rs11544924; rs11544937; rs11544930; rs11544923; rs11544934; rs34034070; rs11544925; rs11544933; rs3082814; rs3082812; rs35162483; rs35711986; rs35210931; rs2883967; rs34921439; rs34721674; rs34410991; rs2883966; rs3082813; rs34243229; rs11267541; rs35011319; rs36034665; rs3841730; rs35645395; rs571019; rs3082787; rs35920515; rs34459762; rs12073500; rs488339; rs35644134; rs33912909; rs11211128; rs34960532; rs36121621; rs34245583; rs34613718; rs34820242; rs12073413; rs12073560; rs12067882; rs12073406; rs10610450; rs35722848; rs35407028; rs10700951; rs3790584; rs34084172; rs12065695; rs34367785; rs12066809; rs34713645; rs34098846; rs1044711; rs1044717; rs10789465; rs11211133; rs12029322; rs12083690; rs12124178; rs16832553; rs2275276; rs4660307; rs7522705; rs7903; rs945179

# Metabolic_Enzyme_23_General_References:
8496166; 8026862; 12059788; 11986303; 12161445

# Metabolic_Enzyme_23_References:
Not Available

# Metabolic_Enzyme_24_ID:
8542

# Metabolic_Enzyme_24_Name:
Peroxiredoxin-2

# Metabolic_Enzyme_24_Synonyms:
Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; Thiol-specific antioxidant protein; TSA; PRP; Natural killer cell-enhancing factor B; NKEF-B

# Metabolic_Enzyme_24_Gene_Name:
PRDX2

# Metabolic_Enzyme_24_Protein_Sequence:
>Peroxiredoxin2
MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSN
RAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLKT
DEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGS
DTIKPNVDDSKEYFSKHN

# Metabolic_Enzyme_24_Number_of_Residues:
198

# Metabolic_Enzyme_24_Molecular_Weight:
21892

# Metabolic_Enzyme_24_Theoretical_pI:
5.75

# Metabolic_Enzyme_24_GO_Classification:
Not Available

# Metabolic_Enzyme_24_General_Function:
Posttranslational modification, protein turnover, chaperones

# Metabolic_Enzyme_24_Specific_Function:
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)

# Metabolic_Enzyme_24_Pathway:
Not Available

# Metabolic_Enzyme_24_Reaction:
2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH

# Metabolic_Enzyme_24_Pfam_Domain_Function:
PF00578:AhpC-TSA

# Metabolic_Enzyme_24_Signals:
Not Available

# Metabolic_Enzyme_24_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 1.11.1.15

# Metabolic_Enzyme_24_GenBank_ID_Protein:
438069

# Metabolic_Enzyme_24_SwissProt_ID:
PRDX2_HUMAN (P32119)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
PRDX2

# Metabolic_Enzyme_24_Geneatlas_id:
PRDX2

# Metabolic_Enzyme_24_hgnc_id:
HGNC:9353

# Metabolic_Enzyme_24_PDB_ID:
1QMV

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_24_Gene_Sequence:
>597 bp
ATGGCCTCCGGTAACGCGCGCATCGGAAAGCCAGCCCCTGACTTCAAGGCCACAGCGGTG
GTTGATGGCGCCTTCAAAGAGGTGAAGCTGTCGGACTACAAAGGGAAGTACGTGGTCCTC
TTTTTCTACCCTCTGGACTTCACTTTTGTGTGCCCCACCGAGATCATCGCGTTCACAACC
GTGAAGAGGACTTCCGCAAAGCTGGGCTGTGAAGTGCTGGGCGTCTCGGTGGACTCTCAG
TTCACCCACCTGGCTTGGATCAACACCCCCCGGAAAGAGGGAGGCTTGGGCCCCTTGAAC
ATCCCCCTGCTTGCTGACGTGACCAGACGCTTGTCTGAGGATTACGGCGTGCTGAAAAAC
GATGAGGGCATTGCTTACAGGGGCCTCTTTATCATCGATGGCAAGGGTGTCCTTCGCCAG
ATCACTGTTAATGATTTGCCTGTGGGACGCTCCGTGGATGAGGCTCTGCGGCTGGTCCAG
GCCTTCCAGTACACAGACGAGCATGGGGAAGTTTGTCCGGCTGCTTGGAAGCCTGGACGT
GACACGATTAAGCCGAACGTGGATGACAGCAAGGAATATTTCTCCAAACACAATTAG

# Metabolic_Enzyme_24_GenBank_ID_Gene:
Z22548

# Metabolic_Enzyme_24_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_24_Locus:
19p13.2

# Metabolic_Enzyme_24_SNPs:
rs12151144; rs34231866; rs10427027; rs10422248; rs10413408; rs1205171; rs12461569; rs10421102; rs35866106; rs10405263; rs10407474; rs8107906; rs10423224; rs8104763; rs10404253; rs34226478; rs35501398; rs35498319; rs35718591; rs34577345; rs34012472; rs11554740; rs1804014; rs1056648; rs11554743; rs11554741; rs11554745; rs1135005; rs11554739; rs1804013; rs1057382; rs1057443; rs3198034; rs11554744; rs1064144; rs35458831; rs34945258; rs10405448; rs10405896; rs35372151; rs34186581; rs10405267; rs36027230; rs7254429; rs34793895; rs7251140; rs10421604; rs1046220; rs1061500; rs1061595; rs11554400; rs11879599; rs11882945; rs12461559; rs13345720; rs2229510; rs2515724; rs2599483; rs2599484; rs2599485; rs2607354; rs28603316; rs3907089; rs7247253; rs7247284; rs7257575; rs7258279

# Metabolic_Enzyme_24_General_References:
8144038; 8026862; 1286667; 8313871; 9150948; 11904290

# Metabolic_Enzyme_24_References:
Not Available

# Metabolic_Enzyme_25_ID:
8596

# Metabolic_Enzyme_25_Name:
Thioredoxin-dependent peroxide reductase, mitochondrial precursor

# Metabolic_Enzyme_25_Synonyms:
Peroxiredoxin-3; PRX III; Antioxidant protein 1; AOP-1; Protein MER5 homolog; HBC189

# Metabolic_Enzyme_25_Gene_Name:
PRDX3

# Metabolic_Enzyme_25_Protein_Sequence:
>Thioredoxindependent peroxide reductase, mitochondrial precursor
MAAAVGRLLRASVARHVSAIPWGISATAALRPAACGRTSLTNLLCSGSSQAKLFSTSSSC
HAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKAN
EFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIALLSDLTKQISRDYGVLLEGSG
LALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKAFQYVETHGEVCPANWTPDSPTI
KPSPAASKEYFQKVNQ

# Metabolic_Enzyme_25_Number_of_Residues:
256

# Metabolic_Enzyme_25_Molecular_Weight:
27693

# Metabolic_Enzyme_25_Theoretical_pI:
7.88

# Metabolic_Enzyme_25_GO_Classification:
Not Available

# Metabolic_Enzyme_25_General_Function:
Posttranslational modification, protein turnover, chaperones

# Metabolic_Enzyme_25_Specific_Function:
Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical- generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol

# Metabolic_Enzyme_25_Pathway:
Not Available

# Metabolic_Enzyme_25_Reaction:
2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH

# Metabolic_Enzyme_25_Pfam_Domain_Function:
PF00578:AhpC-TSA

# Metabolic_Enzyme_25_Signals:
1-19

# Metabolic_Enzyme_25_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_25_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_25_EC_Link:
EC 1.11.1.15

# Metabolic_Enzyme_25_GenBank_ID_Protein:
682748

# Metabolic_Enzyme_25_SwissProt_ID:
PRDX3_HUMAN (P30048)

# Metabolic_Enzyme_25_swissprot_Name:
Not Available

# Metabolic_Enzyme_25_Genecard_id:
PRDX3

# Metabolic_Enzyme_25_Geneatlas_id:
PRDX3

# Metabolic_Enzyme_25_hgnc_id:
HGNC:9354

# Metabolic_Enzyme_25_PDB_ID:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_25_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_25_Gene_Sequence:
>771 bp
ATGGCGGCTGCTGTAGGACGGTTGCTCCGAGCGTCGGTTGCCCGACATGTGAGTGCCATT
CCTTGGGGCATTTCTGCCACTGCAGCCCTCAGGCCTGCTGCATGTGGAAGAACGAGCTTG
ACAAATTTATTGTGTTCTGGTTCCAGTCAAGCAAAATTATTCAGCACCAGTTCCTCATGC
CATGCACCTGCTGTCACCCAGCATGCACCCTATTTTAAGGGTACAGCCGTTGTCAATGGA
GAGTTCAAAGACCTAAGCCTTGATGACTTTAAGGGGAAATATTTGGTGCTTTTCTTCTAT
CCTTTGGATTTCACCTTTGTGTGTCCTACAGAAATTGTTGCTTTTAGTGACAAAGCTAAC
GAATTTCACGATGTGAACTGTGAAGTTGTCGCAGTCTCAGTGGATTCCCACTTTAGCCAT
CTTGCCTGGATAAATACACCAAGAAAGAATGGTGGTTTGGGCCACATGAACATCGCACTC
TTGTCAGACTTAACTAAGCAGATTTCCCGAGACTACGGTGTGCTGTTAGAAGGTTCTGGT
CTTGCACTAAGAGGTCTCTTCATAATTGACCCCAATGGAGTCATCAAGCATTTGAGCGTC
AACGATCTCCCAGTGGGCCGAAGCGTGGAAGAAACCCTCCGCTTGGTGAAGGCGTTCCAG
TATGTAGAAACACATGGAGAAGTCTGCCCAGCGAACTGGACACCGGATTCTCCTACGATC
AAGCCAAGTCCAGCTGCTTCCAAAGAGTACTTTCAGAAGGTAAATCAGTAG

# Metabolic_Enzyme_25_GenBank_ID_Gene:
D49396

# Metabolic_Enzyme_25_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_25_Locus:
10q25-q26

# Metabolic_Enzyme_25_SNPs:
rs35697338; rs3758609; rs7768; rs3377; rs35226258; rs34132718; rs3781493; rs3740562; rs10749296; rs7076209; rs3758610; rs10886408; rs2271362; rs10886407; rs33987628; rs7076516; rs11198810; rs9651477; rs36071611; rs35652120; rs7915860; rs34742566; rs35815158; rs4752258; rs11198809; rs34793961; rs7915811; rs34482620; rs35789704; rs34862689; rs7916250; rs36075462; rs34324311; rs11198811; rs10749298; rs35648108; rs10749295; rs35985400; rs10749297; rs35920416; rs34058857; rs4752259; rs35398270; rs36051731; rs4752257; rs34364753; rs34524935; rs35196296; rs36028551; rs11198808; rs34983296; rs9651422; rs7916477; rs17098495; rs36119116; rs35326250; rs1553850; rs3824825; rs1973599; rs35409420; rs35665723; rs1553851; rs34232743; rs6585537; rs11554920; rs11554918; rs36064375; rs11554900; rs11554916; rs11554902; rs11554919; rs11554910; rs17850322; rs34698541; rs11554909; rs11554923; rs11554915; rs11554917; rs11554903; rs11554924; rs17851910; rs11554921; rs17098493; rs1803115; rs34057655; rs34339894; rs3834425; rs35455129; rs35217475; rs35236130; rs34176975; rs35950286; rs34442267; rs35136200; rs35909494; rs11305694; rs34665257; rs35565933; rs35542401; rs35999007; rs34423143; rs34090064; rs35631594; rs35166020; rs34023076; rs35837274; rs35374566; rs35604808; rs34258458; rs35105949; rs35015694; rs12763273; rs34816388; rs34820945; rs34948228; rs35370028; rs35647227; rs34910005; rs34523516; rs34358316; rs34010959; rs35401146; rs35131241; rs35950593; rs35634401; rs34798140; rs34982197; rs34746598; rs12251036; rs3842245; rs34737623; rs9731583; rs36047945; rs34235402; rs34178103; rs34597289; rs34646283; rs3061124; rs2275113; rs5788330; rs1041686; rs10886412; rs1812199; rs1875335; rs2146053; rs2146054; rs2181118; rs2275111; rs2275112; rs2275126; rs2282254; rs2420494; rs3740558; rs7069697; rs7914698; rs925388; rs933092

# Metabolic_Enzyme_25_General_References:
7733872; 1286669; 12059788; 12492477

# Metabolic_Enzyme_25_References:
Not Available

# Metabolic_Enzyme_26_ID:
8710

# Metabolic_Enzyme_26_Name:
Hydroxyacylglutathione hydrolase-like isoform 1 variant

# Metabolic_Enzyme_26_Synonyms:
Not Available

# Metabolic_Enzyme_26_Gene_Name:
Not Available

# Metabolic_Enzyme_26_Protein_Sequence:
>Hydroxyacylglutathione hydrolaselike isoform 1 variant
PSPLRTALPRVWRAGPALKGHRGLGGLFWSRHRWPSSVTMKVKVIPVLEDNYMYLVIEEL
TREAVAVDVAVPKRLLEIVGREGVSLTAVLTTHHHWDHARGNPELARLRPGLAVLGADER
IFSLTRRLAHGEELRFGAIHVRCLLTPGHTAGHMSYFLWEDDCPDPPALFSGDALSVAGC
GSCLEGSAQQMYQSLAELGTLPPETKVFCGHEHTLSNLEFAQKVEPCNDHLVYA

# Metabolic_Enzyme_26_Number_of_Residues:
234

# Metabolic_Enzyme_26_Molecular_Weight:
25836

# Metabolic_Enzyme_26_Theoretical_pI:
6.99

# Metabolic_Enzyme_26_GO_Classification:
Not Available

# Metabolic_Enzyme_26_General_Function:
Not Available

# Metabolic_Enzyme_26_Specific_Function:
Not Available

# Metabolic_Enzyme_26_Pathway:
Not Available

# Metabolic_Enzyme_26_Reaction:
Not Available

# Metabolic_Enzyme_26_Pfam_Domain_Function:
PF00753:Lactamase_B

# Metabolic_Enzyme_26_Signals:
Not Available

# Metabolic_Enzyme_26_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_26_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_26_EC_Link:
EC 3.1.2.6

# Metabolic_Enzyme_26_GenBank_ID_Protein:
62088242

# Metabolic_Enzyme_26_SwissProt_ID:
Q59FX8_HUMAN (Q59FX8)

# Metabolic_Enzyme_26_swissprot_Name:
Not Available

# Metabolic_Enzyme_26_Genecard_id:
Not Available

# Metabolic_Enzyme_26_Geneatlas_id:
Not Available

# Metabolic_Enzyme_26_hgnc_id:
HGNC:14177

# Metabolic_Enzyme_26_PDB_ID:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_26_Subcellular_Location:
Not Available

# Metabolic_Enzyme_26_Gene_Sequence:
>705 bp
CCGAGCCCGCTTCGCACAGCCCTTCCTAGGGTGTGGAGAGCGGGCCCCGCCCTGAAGGGG
CACCGTGGGCTGGGGGGCCTGTTTTGGAGCAGGCACCGGTGGCCGAGCTCCGTGACCATG
AAGGTCAAGGTCATCCCCGTGCTCGAGGACAACTACATGTACCTGGTCATCGAGGAGCTC
ACGCGCGAGGCGGTGGCCGTGGACGTGGCTGTGCCCAAGAGGCTGCTGGAGATCGTGGGC
CGGGAGGGGGTGTCTCTGACCGCTGTGCTGACCACCCACCATCACTGGGACCACGCGCGG
GGAAACCCGGAGCTGGCGCGGCTTCGTCCCGGGCTGGCGGTGCTGGGCGCGGACGAGCGC
ATCTTCTCGCTGACGCGCAGGCTGGCGCACGGCGAGGAGCTGCGGTTCGGGGCCATCCAC
GTGCGTTGCCTCCTGACGCCCGGCCACACCGCCGGCCACATGAGCTACTTCCTGTGGGAG
GACGATTGCCCGGACCCACCCGCCCTGTTCTCGGGCGACGCGCTGTCGGTGGCCGGCTGC
GGCTCGTGCCTGGAGGGCAGCGCCCAGCAGATGTACCAGAGCCTGGCCGAGCTGGGTACC
CTGCCCCCCGAGACGAAGGTGTTCTGCGGCCACGAGCACACGCTTAGCAACCTGGAGTTT
GCCCAGAAAGTGGAGCCCTGCAACGACCACTTGGTGTATGCGTGA

# Metabolic_Enzyme_26_GenBank_ID_Gene:
AB209331

# Metabolic_Enzyme_26_Chromosome_Location:
Not Available

# Metabolic_Enzyme_26_Locus:
Not Available

# Metabolic_Enzyme_26_SNPs:
Not Available

# Metabolic_Enzyme_26_General_References:
Not Available

# Metabolic_Enzyme_26_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7549

# Macromolecular_Interacting_Partner_1_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
INS

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_1_Signals:
1-24

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
INS

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11p15.5

# Macromolecular_Interacting_Partner_1_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_1_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_1_References:
16886206

# Macromolecular_Interacting_Partner_2_ID:
7551

# Macromolecular_Interacting_Partner_2_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_2_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_2_Locus:
6p21.3

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_2_References:
17079650; 17080400

# Macromolecular_Interacting_Partner_3_ID:
6878

# Macromolecular_Interacting_Partner_3_Name:
Catalase

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
CAT

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Catalase
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT
KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD
THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE
HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK
NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
527

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
59757

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
7.41

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  catalase activity
 ||
>>>
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_3_Specific_Function:
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide

# Macromolecular_Interacting_Partner_3_Pathway:
map00380  Tryptophan metabolism;
 map00680  Methane metabolism

# Macromolecular_Interacting_Partner_3_Reaction:
2 H2O2 = O2 + 2 H2O

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00199:Catalase

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
EC 1.11.1.6

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
1228085

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
CATA_HUMAN (P04040)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
CAT

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
CAT

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:1516

# Macromolecular_Interacting_Partner_3_PDB_ID:
1F4J

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Peroxisome

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>66 bp
ATGGCTGACAGCCGGGATCCCGCCAGCGACCAGATGCAGCACTGGAAGGAGCAGCGGGCC
GCGCAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
X04085

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11p13

# Macromolecular_Interacting_Partner_3_SNPs:
rs17880442; rs11032709; rs769217; rs35677492; rs1049982; rs2234940; rs1050032; rs566979; rs769218; rs511895; rs524167; rs494024; rs1408035; rs560807; rs10488736; rs2284367; rs482322; rs7947841; rs480496; rs11032699; rs2300182; rs2284365; rs7103083; rs499406; rs3758730; rs4755372; rs508370; rs7933285; rs1000343; rs554576; rs2073059; rs11032701; rs17886008; rs4755373; rs484214; rs6484722; rs543701; rs17884666; rs2420389; rs551929; rs480575; rs10836244; rs2179625; rs7113917; rs2268063; rs533425; rs12272630; rs17881488; rs486256; rs17884576; rs2073058; rs11604331; rs17884491; rs7120960; rs1408034; rs524154; rs7109778; rs7101395; rs17881288; rs12269988; rs7126610; rs10836235; rs16925608; rs16925614; rs11824384; rs2284368; rs17883121; rs2420388; rs4756146; rs16925606; rs17884086; rs2284364; rs7930427; rs12803540; rs1408036; rs17268652; rs2284366; rs17881567; rs2300181; rs7928213; rs11032702; rs16925581; rs525938; rs11032700; rs17881921; rs17884095; rs17885743; rs17881476; rs17883793; rs11826620; rs12270780; rs35915891; rs2268064; rs17883592; rs17884725; rs17881482; rs17880673; rs2284369; rs17883544; rs11032703; rs12273124; rs17884248; rs35755143; rs7126640; rs2076556; rs4755374; rs1055981; rs17884335; rs17884518; rs17880274; rs17883699; rs4756148; rs17886200; rs475043; rs564250; rs769214; rs9282626; rs7943316; rs9282627; rs7104301; rs17883920; rs1001179; rs17881029; rs17886350; rs2266625; rs34455645; rs3180560; rs11546300; rs1050028; rs2266629; rs2266619; rs14527; rs2266628; rs35012776; rs34964953; rs34727149; rs3831770; rs17886810; rs35927227; rs7121850; rs17885881; rs17882812; rs17885837; rs17880607; rs17882039; rs17881916; rs17880549; rs34138762; rs28586982; rs34503767; rs36074933; rs515130; rs35099202; rs35849009; rs17881846; rs17887048; rs17881224; rs17884421; rs34840731; rs17881231; rs35340649; rs35292563; rs17884242; rs12286702; rs35034960; rs28733253; rs17887248; rs35791482; rs35703808; rs35648206; rs34808995; rs35386961; rs34420404; rs856714; rs17883483; rs17884804; rs17883367; rs17883534; rs17880160; rs17886672; rs34281397; rs34790990; rs2982523; rs35122257; rs2284370; rs12798927; rs35781217; rs11032707; rs17886592; rs4483566; rs34890123; rs4272763; rs12789374; rs17881734; rs35330036; rs17883434; rs35081167; rs17886155; rs17886248; rs34840787; rs34890990; rs17881192; rs17881586; rs34267165; rs12786539; rs35834969; rs3818354; rs17884443; rs36224415; rs36224416; rs36224102; rs10312; rs10836230; rs10836233; rs10836234; rs11032717; rs1107573; rs11606946; rs12284341; rs12807961; rs12808450; rs1323690; rs1535718; rs1535719; rs1535720; rs1535721; rs16925525; rs2073057; rs208678; rs208679; rs208681; rs208682; rs208683; rs2231828; rs2266624; rs2266630; rs2296144; rs409598; rs554518; rs7109862; rs7114869; rs7118388; rs7928156; rs7941147; rs7944397; rs7949972

# Macromolecular_Interacting_Partner_3_General_References:
3755525; 3755526; 11728823; 8282800; 12665801; 6548744; 10666617; 10656833; 11134921

# Macromolecular_Interacting_Partner_3_References:
17004896; 17009256; 17015266; 17042922

# Macromolecular_Interacting_Partner_4_ID:
7375

# Macromolecular_Interacting_Partner_4_Name:
Superoxide dismutase [Mn], mitochondrial precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
SOD2

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Superoxide dismutase Mn, mitochondrial precursor
MLSRAVCGTSRQLAPALGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVN
NLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEA
IKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLL
GIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
222

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
24722

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.45

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  metal ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on superoxide radicals as acceptor
Function:  superoxide dismutase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  superoxide metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_4_Specific_Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
2 O2*- + 2 H+ = O2 + H2O2

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF02777:Sod_Fe_C;
PF00081:Sod_Fe_N

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
EC 1.15.1.1

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
34709

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
SODM_HUMAN (P04179)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SOD2

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SOD2

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11180

# Macromolecular_Interacting_Partner_4_PDB_ID:
1LUV

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>669 bp
ATGTTGAGCCGGGCAGTGTGCGGCACCAGCAGGCAGCTGGCTCCGGCTTTGGGGTATCTG
GGCTCCAGGCAGAAGCACAGCCTCCCCGACCTGCCCTACGACTACGGCGCCCTGGAACCT
CACATCAACGCGCAGATCATGCAGCTGCACCACAGCAAGCACCACGCGGCCTACGTGAAC
AACCTGAACGTCAACGAGGAGAAGTACCAGGAGGCGTTGGCCAAGGGAGATGTTACAGCC
CAGATAGCTCTTCAGCCTGCACTGAAGTTCAATGGTGGTGGTCATATCAATCATAGCATT
TTCTGGACAAACCTCAGCCCTAACGGTGGTGGAGAACCCAAAGGGGAGTTGCTGGAAGCC
ATCAAACGTGACTTTGGTTCCTTTGACAAGTTTAAGGAGAAGCTGACGGCTGCATCTGTT
GGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAACGGGGACACTTACAA
ATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTG
GGGATTGATGTGTGGGAGCACGCTTACTACCTTCAGTATAAAAATGTCAGGCCTGATTAT
CTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAAGATACATGGCTTGC
AAAAAGTAA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
X59445

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_4_Locus:
6q25.3

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
2462451; 3684581; 3399391; 2831093; 1988135; 1699607; 7702755; 14574404; 6386798; 7895732; 7498159; 9150946; 1394426; 8605177; 9537988; 9537987; 10852710; 11580280

# Macromolecular_Interacting_Partner_4_References:
16859669; 16936909; 16971750; 17131909

# Macromolecular_Interacting_Partner_5_ID:
7603

# Macromolecular_Interacting_Partner_5_Name:
Cystic fibrosis transmembrane conductance regulator

# Macromolecular_Interacting_Partner_5_Synonyms:
CFTR; cAMP- dependent chloride channel; ATP-binding cassette transporter sub- family C member 7

# Macromolecular_Interacting_Partner_5_Gene_Name:
CFTR

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Cystic fibrosis transmembrane conductance regulator
MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRE
LASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIA
IYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQL
VSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGL
GRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAA
YVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQT
WYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRK
TSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEG
KIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIV
LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR
ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNS
ILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQ
MNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQG
QNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESI
PAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRN
NSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAP
MSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATV
PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHK
ALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIM
STLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKK
DDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRL
LNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVAD
EVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVT
YQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQA
ISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
1480

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
168144

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
9.02

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  transporter activity
Function:  ion transporter activity
Function:  ion channel activity
Function:  anion channel activity
Function:  chloride channel activity
Function:  ATPase activity
Function:  hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Function:  ATPase activity, coupled to transmembrane movement of substances
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  ion transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_5_Specific_Function:
Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00664:ABC_membrane;
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
81-103
118-138
195-215
221-241
308-328
331-350
860-880
912-932
991-1011
1014-1034
1103-1123
1129-1149

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
180332

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
CFTR_HUMAN (P13569)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
CFTR

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
CFTR

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:1884

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>4443 bp
ATGCAGAGGTCGCCTCTGGAAAAGGCCAGCGTTGTCTCCAAACTTTTTTTCAGCTGGACC
AGACCAATTTTGAGGAAAGGATACAGACAGCGCCTGGAATTGTCAGACATATACCAAATC
CCTTCTGTTGATTCTGCTGACAATCTATCTGAAAAATTGGAAAGAGAATGGGATAGAGAG
CTGGCTTCAAAGAAAAATCCTAAACTCATTAATGCCCTTCGGCGATGTTTTTTCTGGAGA
TTTATGTTCTATGGAATCTTTTTATATTTAGGGGAAGTCACCAAAGCAGTACAGCCTCTC
TTACTGGGAAGAATCATAGCTTCCTATGACCCGGATAACAAGGAGGAACGCTCTATCGCG
ATTTATCTAGGCATAGGCTTATGCCTTCTCTTTATTGTGAGGACACTGCTCCTACACCCA
GCCATTTTTGGCCTTCATCACATTGGAATGCAGATGAGAATAGCTATGTTTAGTTTGATT
TATAAGAAGACTTTAAAGCTGTCAAGCCGTGTTCTAGATAAAATAAGTATTGGACAACTT
GTTAGTCTCCTTTCCAACAACCTGAACAAATTTGATGAAGGACTTGCATTGGCACATTTC
GTGTGGATCGCTCCTTTGCAAGTGGCACTCCTCATGGGGCTAATCTGGGAGTTGTTACAG
GCGTCTGCCTTCTGTGGACTTGGTTTCCTGATAGTCCTTGCCCTTTTTCAGGCTGGGCTA
GGGAGAATGATGATGAAGTACAGAGATCAGAGAGCTGGGAAGATCAGTGAAAGACTTGTG
ATTACCTCAGAAATGATTGAAAATATCCAATCTGTTAAGGCATACTGCTGGGAAGAAGCA
ATGGAAAAAATGATTGAAAACTTAAGACAAACAGAACTGAAACTGACTCGGAAGGCAGCC
TATGTGAGATACTTCAATAGCTCAGCCTTCTTCTTCTCAGGGTTCTTTGTGGTGTTTTTA
TCTGTGCTTCCCTATGCACTAATCAAAGGAATCATCCTCCGGAAAATATTCACCACCATC
TCATTCTGCATTGTTCTGCGCATGGCGGTCACTCGGCAATTTCCCTGGGCTGTACAAACA
TGGTATGACTCTCTTGGAGCAATAAACAAAATACAGGATTTCTTACAAAAGCAAGAATAT
AAGACATTGGAATATAACTTAACGACTACAGAAGTAGTGATGGAGAATGTAACAGCCTTC
TGGGAGGAGGGATTTGGGGAATTATTTGAGAAAGCAAAACAAAACAATAACAATAGAAAA
ACTTCTAATGGTGATGACAGCCTCTTCTTCAGTAATTTCTCACTTCTTGGTACTCCTGTC
CTGAAAGATATTAATTTCAAGATAGAAAGAGGACAGTTGTTGGCGGTTGCTGGATCCACT
GGAGCAGGCAAGACTTCACTTCTAATGATGATTATGGGAGAACTGGAGCCTTCAGAGGGT
AAAATTAAGCACAGTGGAAGAATTTCATTCTGTTCTCAGTTTTCCTGGATTATGCCTGGC
ACCATTAAAGAAAATATCATCTTTGGTGTTTCCTATGATGAATATAGATACAGAAGCGTC
ATCAAAGCATGCCAACTAGAAGAGGACATCTCCAAGTTTGCAGAGAAAGACAATATAGTT
CTTGGAGAAGGTGGAATCACACTGAGTGGAGGTCAACGAGCAAGAATTTCTTTAGCAAGA
GCAGTATACAAAGATGCTGATTTGTATTTATTAGACTCTCCTTTTGGATACCTAGATGTT
TTAACAGAAAAAGAAATATTTGAAAGCTGTGTCTGTAAACTGATGGCTAACAAAACTAGG
ATTTTGGTCACTTCTAAAATGGAACATTTAAAGAAAGCTGACAAAATATTAATTTTGAAT
GAAGGTAGCAGCTATTTTTATGGGACATTTTCAGAACTCCAAAATCTACAGCCAGACTTT
AGCTCAAAACTCATGGGATGTGATTCTTTCGACCAATTTAGTGCAGAAAGAAGAAATTCA
ATCCTAACTGAGACCTTACACCGTTTCTCATTAGAAGGAGATGCTCCTGTCTCCTGGACA
GAAACAAAAAAACAATCTTTTAAACAGACTGGAGAGTTTGGGGAAAAAAGGAAGAATTCT
ATTCTCAATCCAATCAACTCTATACGAAAATTTTCCATTGTGCAAAAGACTCCCTTACAA
ATGAATGGCATCGAAGAGGATTCTGATGAGCCTTTAGAGAGAAGGCTGTCCTTAGTACCA
GATTCTGAGCAGGGAGAGGCGATACTGCCTCGCATCAGCGTGATCAGCACTGGCCCCACG
CTTCAGGCACGAAGGAGGCAGTCTGTCCTGAACCTGATGACACACTCAGTTAACCAAGGT
CAGAACATTCACCGAAAGACAACAGCATCCACACGAAAAGTGTCACTGGCCCCTCAGGCA
AACTTGACTGAACTGGATATATATTCAAGAAGGTTATCTCAAGAAACTGGCTTGGAAATA
AGTGAAGAAATTAACGAAGAAGACTTAAAGGAGTGCCTTTTTGATGATATGGAGAGCATA
CCAGCAGTGACTACATGGAACACATACCTTCGATATATTACTGTCCACAAGAGCTTAATT
TTTGTGCTAATTTGGTGCTTAGTAATTTTTCTGGCAGAGGTGGCTGCTTCTTTGGTTGTG
CTGTGGCTCCTTGGAAACACTCCTCTTCAAGACAAAGGGAATAGTACTCATAGTAGAAAT
AACAGCTATGCAGTGATTATCACCAGCACCAGTTCGTATTATGTGTTTTACATTTACGTG
GGAGTAGCCGACACTTTGCTTGCTATGGGATTCTTCAGAGGTCTACCACTGGTGCATACT
CTAATCACAGTGTCGAAAATTTTACACCACAAAATGTTACATTCTGTTCTTCAAGCACCT
ATGTCAACCCTCAACACGTTGAAAGCAGGTGGGATTCTTAATAGATTCTCCAAAGATATA
GCAATTTTGGATGACCTTCTGCCTCTTACCATATTTGACTTCATCCAGTTGTTATTAATT
GTGATTGGAGCTATAGCAGTTGTCGCAGTTTTACAACCCTACATCTTTGTTGCAACAGTG
CCAGTGATAGTGGCTTTTATTATGTTGAGAGCATATTTCCTCCAAACCTCACAGCAACTC
AAACAACTGGAATCTGAAGGCAGGAGTCCAATTTTCACTCATCTTGTTACAAGCTTAAAA
GGACTATGGACACTTCGTGCCTTCGGACGGCAGCCTTACTTTGAAACTCTGTTCCACAAA
GCTCTGAATTTACATACTGCCAACTGGTTCTTGTACCTGTCAACACTGCGCTGGTTCCAA
ATGAGAATAGAAATGATTTTTGTCATCTTCTTCATTGCTGTTACCTTCATTTCCATTTTA
ACAACAGGAGAAGGAGAAGGAAGAGTTGGTATTATCCTGACTTTAGCCATGAATATCATG
AGTACATTGCAGTGGGCTGTAAACTCCAGCATAGATGTGGATAGCTTGATGCGATCTGTG
AGCCGAGTCTTTAAGTTCATTGACATGCCAACAGAAGGTAAACCTACCAAGTCAACCAAA
CCATACAAGAATGGCCAACTCTCGAAAGTTATGATTATTGAGAATTCACACGTGAAGAAA
GATGACATCTGGCCCTCAGGGGGCCAAATGACTGTCAAAGATCTCACAGCAAAATACACA
GAAGGTGGAAATGCCATATTAGAGAACATTTCCTTCTCAATAAGTCCTGGCCAGAGGGTG
GGCCTCTTGGGAAGAACTGGATCAGGGAAGAGTACTTTGTTATCAGCTTTTTTGAGACTA
CTGAACACTGAAGGAGAAATCCAGATCGATGGTGTGTCTTGGGATTCAATAACTTTGCAA
CAGTGGAGGAAAGCCTTTGGAGTGATACCACAGAAAGTATTTATTTTTTCTGGAACATTT
AGAAAAAACTTGGATCCCTATGAACAGTGGAGTGATCAAGAAATATGGAAAGTTGCAGAT
GAGGTTGGGCTCAGATCTGTGATAGAACAGTTTCCTGGGAAGCTTGACTTTGTCCTTGTG
GATGGGGGCTGTGTCCTAAGCCATGGCCACAAGCAGTTGATGTGCTTGGCTAGATCTGTT
CTCAGTAAGGCGAAGATCTTGCTGCTTGATGAACCCAGTGCTCATTTGGATCCAGTAACA
TACCAAATAATTAGAAGAACTCTAAAACAAGCATTTGCTGATTGCACAGTAATTCTCTGT
GAACACAGGATAGAAGCAATGCTGGAATGCCAACAATTTTTGGTCATAGAAGAGAACAAA
GTGCGGCAGTACGATTCCATCCAGAAACTGCTGAACGAGAGGAGCCTCTTCCGGCAAGCC
ATCAGCCCCTCCGACAGGGTGAAGCTCTTTCCCCACCGGAACTCAAGCAAGTGCAAGTCT
AAGCCCCAGATTGCTGCTCTGAAAGAGGAGACAGAAGAAGAGGTGCAAGATACAAGGCTT
TAG

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
M28668

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_5_Locus:
7q31.2

# Macromolecular_Interacting_Partner_5_SNPs:
rs213950; rs1800100; rs1800107; rs11971167; rs35032490; rs1800076; rs1800136; rs1800130; rs1042077; rs1800095; rs1800094; rs1042180; rs17140308; rs10234329; rs1800501; rs213966; rs1429568; rs213977; rs2213958; rs2106155; rs213944; rs213951; rs213976; rs213987; rs756665; rs1469486; rs213954; rs117243; rs213936; rs1896888; rs213942; rs213956; rs213968; rs2082056; rs2518881; rs2246450; rs214167; rs2518873; rs885993; rs213955; rs213985; rs213943; rs172507; rs214157; rs2237722; rs213981; rs213952; rs213963; rs2027945; rs1800503; rs2078753; rs2283054; rs213935; rs213984; rs6466614; rs213980; rs11772396; rs4148692; rs7791289; rs2027944; rs10953847; rs2283058; rs213989; rs4727855; rs4148686; rs725188; rs7809485; rs1366917; rs2078754; rs7811667; rs213970; rs7789741; rs6968747; rs213965; rs957461; rs4148691; rs2188158; rs2237724; rs213983; rs2283057; rs214164; rs213972; rs6965682; rs213988; rs2283056; rs7786196; rs739378; rs213974; rs6969138; rs6466613; rs213986; rs428524; rs213946; rs2518879; rs980574; rs2254742; rs4148688; rs213945; rs2402228; rs6957018; rs213982; rs213953; rs1896887; rs213937; rs213964; rs7808474; rs213969; rs2237723; rs6949974; rs213973; rs1896886; rs213934; rs6466615; rs12534186; rs7812185; rs11974545; rs3808184; rs182460; rs2237721; rs7793127; rs10244810; rs6943105; rs7803222; rs213938; rs6979652; rs17449231; rs17140013; rs4148711; rs17450482; rs10487369; rs213958; rs2097609; rs10240654; rs3808183; rs7799504; rs4730787; rs718829; rs6957317; rs213967; rs213962; rs4148698; rs10240521; rs2188159; rs213949; rs17545644; rs17140229; rs17451754; rs17140169; rs6977764; rs10276533; rs214165; rs17449134; rs28517401; rs4148709; rs7797932; rs10249971; rs10262673; rs10487372; rs4148699; rs11770639; rs2402205; rs10262610; rs12538252; rs17139994; rs11978434; rs10266649; rs4148689; rs6971294; rs17547853; rs16870129; rs2402204; rs6466617; rs2518872; rs213961; rs12673260; rs10272001; rs17140297; rs7802924; rs17449197; rs17132549; rs6951141; rs3757802; rs3808186; rs4148706; rs6942892; rs113839; rs10155917; rs213933; rs12533524; rs7779015; rs3779543; rs4148690; rs7778541; rs10266116; rs10276355; rs6943074; rs214156; rs28415076; rs1820871; rs6466616; rs17547485; rs10224175; rs3808185; rs10487368; rs10487371; rs10281281; rs4148696; rs213957; rs7783208; rs10156138; rs6980032; rs17140095; rs28472519; rs2283055; rs10264892; rs2237725; rs34855237; rs2237726; rs10246649; rs28449716; rs213947; rs4148703; rs10276431; rs4148687; rs213979; rs17140299; rs17139984; rs17549557; rs17139943; rs35031429; rs34480179; rs35475211; rs7357343; rs34581373; rs1429566; rs2299444; rs2106152; rs34927137; rs35506750; rs4148717; rs35674779; rs34849722; rs34567454; rs4148724; rs35608825; rs34364422; rs34683806; rs7457653; rs35987553; rs1025342; rs1429562; rs6969578; rs35995554; rs34268361; rs4570091; rs34420782; rs35003065; rs34159932; rs6966254; rs34844161; rs10225787; rs36042090; rs2027946; rs34456592; rs13221882; rs35294574; rs34652497; rs2106153; rs11974978; rs35900505; rs6945467; rs35993090; rs34606983; rs17140174; rs718830; rs35855138; rs35775845; rs34674313; rs10239473; rs34331324; rs35334650; rs213975; rs34637736; rs1557630; rs34906874; rs1014620; rs1366913; rs213991; rs35533040; rs34034651; rs6944750; rs1429560; rs35384080; rs213971; rs35305858; rs35820454; rs12670673; rs35244428; rs35141759; rs4148714; rs2299445; rs35320768; rs34464201; rs214163; rs35715578; rs7811369; rs17547533; rs35130797; rs35097594; rs11764887; rs34823554; rs36046385; rs2188150; rs4148697; rs34201995; rs35403869; rs34638253; rs35783977; rs35388491; rs1429565; rs1429561; rs34309075; rs35553213; rs35504264; rs35278595; rs34979995; rs10487370; rs34587451; rs4148713; rs4148682; rs1013075; rs1800106; rs1800092; rs1800123; rs1800097; rs1800074; rs35722447; rs34911792; rs1800078; rs1800085; rs3034796; rs36210737; rs1800103; rs1800089; rs1800072; rs1800101; rs35396083; rs1800112; rs1800079; rs4727853; rs1800086; rs1800073; rs1800111; rs1800099; rs41290377; rs35516286; rs1800120; rs1800110; rs1800080; rs35813506; rs1800087; rs11531593; rs1801178; rs1800114; rs4148725; rs766874; rs1800093; rs1800081; rs1800109; rs1800113; rs1800088; rs1800071; rs1800122; rs1800131; rs1800117; rs1800075; rs1800096; rs1800119; rs1800135; rs1800116; rs1800121; rs1800082; rs1800104; rs2896225; rs1800132; rs1800115; rs1800129; rs35033453; rs1800090; rs1800118; rs1800134; rs1800102; rs1800083; rs1800077; rs1800105; rs1800084; rs1800133; rs1800108; rs1799834; rs1800128; rs1800070; rs1042166; rs34255446; rs3181644; rs35441557; rs28771969; rs3840657; rs34530771; rs35603916; rs34623881; rs34412203; rs35821559; rs35380228; rs34994599; rs34334041; rs35445590; rs36024281; rs3958007; rs35521564; rs35191413; rs4148704; rs35135985; rs1366914; rs13223629; rs213990; rs5886865; rs35178333; rs34239891; rs34000781; rs41281087; rs34016528; rs34507966; rs34463627; rs35855809; rs34114986; rs34222059; rs34624661; rs34628207; rs34560599; rs4148716; rs1975071; rs34558486; rs10281871; rs35666329; rs34231750; rs35433853; rs35824078; rs34448325; rs4148708; rs34362542; rs7357279; rs3993862; rs34851557; rs12536210; rs13437792; rs10677637; rs35189260; rs13238114; rs13232769; rs35924144; rs28590120; rs35714998; rs34442917; rs34225590; rs7457735; rs34795348; rs35207043; rs213948; rs34641663; rs13309662; rs34394575; rs35063389; rs35239381; rs34376865; rs35086442; rs35508774; rs34080224; rs35173620; rs34179723; rs35273275; rs35920406; rs34105750; rs13245896; rs34593753; rs35766024; rs2163099; rs10264962; rs34746362; rs508802; rs34668560; rs35248762; rs36001070; rs35283383; rs34517638; rs35228854; rs34066264; rs34812579; rs34589374; rs35396010; rs34518775; rs28558723; rs6955409; rs35396968; rs10229261; rs34870970; rs2518880; rs35633625; rs10550816; rs5886862; rs34511406; rs35194808; rs11762363; rs34248182; rs34339278; rs3840656; rs34400990; rs35904760; rs34277788; rs3034763; rs35313680; rs13239053; rs34410639; rs34360978; rs10614219; rs35728133; rs13438309; rs12668979; rs10232579; rs35859638; rs2023331; rs34027651; rs35260815; rs35066567; rs34735848; rs35616800; rs28594614; rs34276900; rs5886860; rs34914602; rs34433037; rs34010645; rs34047738; rs213941; rs13244984; rs35348526; rs28424587; rs35490261; rs35521194; rs596293; rs35162600; rs34383834; rs1896884; rs35342599; rs34732112; rs213940; rs4148701; rs4646205; rs13309661; rs34863610; rs34345001; rs34568382; rs36005386; rs4148720; rs34062555; rs35504055; rs34942345; rs10655920; rs1429567; rs4727854; rs28627628; rs4148710; rs36143091; rs34630111; rs34973305; rs35045003; rs34403015; rs34623047; rs4730788; rs34487154; rs34164989; rs34400048; rs35421075; rs35917213; rs13228570; rs35001289; rs12674149; rs4148715; rs17139964; rs35547457; rs35345004; rs10271445; rs35667431; rs35701757; rs35114123; rs4382409; rs34773874; rs35722251; rs11343468; rs11767017; rs422903; rs11443412; rs35346641; rs35988166; rs34193229; rs7457781; rs5886864; rs35836271; rs35199653; rs36107057; rs35700857; rs34035263; rs5886861; rs34886238; rs35889249; rs10264982; rs4148719; rs35541900; rs34484276; rs7357277; rs35942171; rs36033279; rs2896228; rs34717021; rs4148685; rs35105447; rs34736744; rs35434314; rs213959; rs34872089; rs11316515; rs35604119; rs10232232; rs35129070; rs35802750; rs35493996; rs35937137; rs34732049; rs35986679; rs10232573; rs4148695; rs34683874; rs7457732; rs35337904; rs4148702; rs34013793; rs35693763; rs34034688; rs35233944; rs34641511; rs34792223; rs35538989; rs34320215; rs10229820; rs5886859; rs34089570; rs35913327; rs35628262; rs35778610; rs35802833; rs3034759; rs34951012; rs34808223; rs34771810; rs34633427; rs36055118; rs34966030; rs35847360; rs35777371; rs35657815; rs35861262; rs34180375; rs35637601; rs35796593; rs35597709; rs34654194; rs35453278; rs13223623; rs34995970; rs35746597; rs34042174; rs28645294; rs35278352; rs11338754; rs3840654; rs3832534; rs2402206; rs11441201; rs35091062; rs35463889; rs35942697; rs3808189; rs5886870; rs35128028; rs4148693; rs1800502; rs35861555; rs34721490; rs35253939; rs35531523; rs34056920; rs34470402; rs10277521; rs4148684; rs3034794; rs35653285; rs35011694; rs3824027; rs36053606; rs34209052; rs34179833; rs35453239; rs35797246; rs36057583; rs3216281; rs34689837; rs34197594; rs11335020; rs35641133; rs2163100; rs13231082; rs34977231; rs10229250; rs34314195; rs35254620; rs34489981; rs4148707; rs34229114; rs35113266; rs11393719; rs34181727; rs35197837; rs10604610; rs35737756; rs35098671; rs34050492; rs7455314; rs35753200; rs35480497; rs35242561; rs35860379; rs10249707; rs34858277; rs34599010; rs35141610; rs35250799; rs4148722; rs35537814; rs35225336; rs34092224; rs34174646; rs9691378; rs34610095; rs35980778; rs1429564; rs2157735; rs5886867; rs213939; rs1366916; rs34858416; rs11343448; rs35071293; rs35682006; rs35784120; rs213960; rs35715131; rs34466297; rs10708994; rs11430349; rs35376221; rs35545882; rs34063663; rs3035712; rs34208245; rs4148694; rs11305516; rs13238110; rs34131894; rs34007053; rs35087944; rs10591889; rs34877038; rs7350044; rs35388998; rs35921938; rs35447324; rs34990919; rs35358095; rs12536236; rs34004297; rs34487764; rs34543279; rs13245053; rs5886869; rs2299443; rs34123455; rs35395275; rs4439060; rs35573776; rs35164769; rs13220943; rs4148712; rs1583061; rs3993863; rs213978; rs35131082; rs34419743; rs35183640; rs34021589; rs34752468; rs35050470; rs35806580; rs10237367; rs35313962; rs7457780; rs2299442; rs5886866; rs1366915; rs11299909; rs35357994; rs13242295; rs11299910; rs34644747; rs35050594; rs35810177; rs9690726; rs34477331; rs34451243; rs34171310; rs3958006; rs34779265; rs10614220; rs34491799; rs34018535; rs35381245; rs13240972; rs35773231; rs35546286; rs34285652; rs35028662; rs1800687; rs35647432; rs11393567; rs35003674; rs35547336; rs34830471; rs214166; rs34280233; rs35158649; rs35470760; rs35026177; rs35916162; rs35147826; rs34671892; rs13225696; rs717918; rs35314519; rs10229103; rs34263755; rs35915869; rs36066143; rs34047196; rs2896226; rs10232910; rs34168687; rs35828781; rs11770751; rs35142890; rs34260394; rs34020733; rs35134989; rs35537576; rs35347718; rs34193416; rs35144548; rs4148721; rs34983001; rs36082161; rs34453441; rs36026445; rs3035687; rs10649319; rs35435021; rs35036571; rs35615558; rs35853854; rs34607500; rs13223535; rs34861365; rs10260471; rs4148718; rs35454375; rs3840655; rs35953502; rs10229115; rs13232912; rs34427586; rs3808187; rs34548759; rs1013076; rs34210368; rs34465975; rs4148683; rs34366889; rs34347530; rs35871908; rs10227664; rs10245438; rs10270610; rs10272233; rs11764070; rs13237279; rs1366912; rs17139920; rs17139922; rs17139925; rs17139929; rs17544734; rs177284; rs214159; rs214160; rs43035; rs43036; rs6943317; rs713134; rs7810506

# Macromolecular_Interacting_Partner_5_General_References:
2475911; 1710598; 12853948; 12690205; 1377674; 9385646; 11707463; 1378801; 9517543; 11304524; 1284534; 1695717; 2236053; 1710600; 1284466; 1284468; 1284530; 1284529; 7680525; 7683628; 7683954; 7505694; 7504969; 7522211; 7513296; 7525450; 7520022; 7524913; 7524909; 7517264; 8081395; 7529962; 7539342; 7544319; 8522333; 7537150; 7541273; 7581407; 7543567; 7541510; 8800923; 8829633; 8723693; 8723695; 8956039; 9067761; 9101301; 9222768; 9375855; 9401006; 9443874; 9521595; 9921909; 9736778; 9482579; 9554753; 9452048; 9452054; 9452073; 10094564

# Macromolecular_Interacting_Partner_5_References:
16763223; 16877677; 16934416

# Macromolecular_Interacting_Partner_6_ID:
7252

# Macromolecular_Interacting_Partner_6_Name:
Multidrug resistance-associated protein 1

# Macromolecular_Interacting_Partner_6_Synonyms:
ATP-binding cassette sub- family C member 1; Leukotriene C(4transporter; LTC4 transporter

# Macromolecular_Interacting_Partner_6_Gene_Name:
ABCC1

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Multidrug resistanceassociated protein 1
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITTLLA
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND
SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLAR
AVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIV
MSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGM
LVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL
SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG
ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL
DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL
KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA
VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA
VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG
EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF
SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCL
ARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVL
DKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
1531

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
171563

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
7.11

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  transporter activity
Function:  ATPase activity
Function:  hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Function:  ATPase activity, coupled to transmembrane movement of substances
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_6_Specific_Function:
May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Confers resistance to anticancer drugs. Transports LTC4. May protect milk against xenobiotics

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00664:ABC_membrane;
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
34-54
75-95
101-121
134-154
173-193
317-337
364-384
441-461
465-485
548-568
591-611
968-988
1026-1046
1090-1110
1112-1132
1204-1224
1227-1247

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
1835659

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
MRP1_HUMAN (P33527)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
ABCC1

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
ABCC1

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:51

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>4596 bp
ATGGCGCTCCGGGGCTTCTGCAGCGCCGATGGCTCCGACCCGCTCTGGGACTGGAATGTC
ACGTGGAATACCAGCAACCCCGACTTCACCAAGTGCTTTCAGAACACGGTCCTCGTGTGG
GTGCCTTGTTTTTACCTCTGGGCCTGTTTCCCCTTCTACTTCCTCTATCTCTCCCGACAT
GACCGAGGCTACATTCAGATGACACCTCTCAACAAAACCAAAACTGCCTTGGGATTTTTG
CTGTGGATCGTCTGCTGGGCAGACCTCTTCTACTCTTTCTGGGAAAGAAGTCGGGGCATA
TTCCTGGCCCCAGTGTTTCTGGTCAGCCCAACTCTCTTGGGCATCACCACGCTGCTTGCT
ACCTTTTTAATTCAGCTGGAGAGGAGGAAGGGAGTTCAGTCTTCAGGGATCATGCTCACT
TTCTGGCTGGTAGCCCTAGTGTGTGCCCTAGCCATCCTGAGATCCAAAATTATGACAGCC
TTAAAAGAGGATGCCCAGGTGGACCTGTTTCGTGACATCACTTTCTACGTCTACTTTTCC
CTCTTACTCATTCAGCTCGTCTTGTCCTGTTTCTCAGATCGCTCACCCCTGTTCTCGGAA
ACCATCCACGACCCTAATCCCTGCCCAGAGTCCAGCGCTTCCTTCCTGTCGAGGATCACC
TTCTGGTGGATCACAGGGTTGATTGTCCGGGGCTACCGCCAGCCCCTGGAGGGCAGTGAC
CTCTGGTCCTTAAACAAGGAGGACACGTCGGAACAAGTCGTGCCTGTTTTGGTAAAGAAC
TGGAAGAAGGAATGCGCCAAGACTAGGAAGCAGCCGGTGAAGGTTGTGTACTCCTCCAAG
GATCCTGCCCAGCCGAAAGAGAGTTCCAAGGTGGATGCGAATGAGGAGGTGGAGGCTTTG
ATCGTCAAGTCCCCACAGAAGGAGTGGAACCCCTCTCTGTTTAAGGTGTTATACAAGACC
TTTGGGCCCTACTTCCTCATGAGCTTCTTCTTCAAGGCCATCCACGACCTGATGATGTTT
TCCGGGCCGCAGATCTTAAAGTTGCTCATCAAGTTCGTGAATGACACGAAGGCCCCAGAC
TGGCAGGGCTACTTCTACACCGTGCTGCTGTTTGTCACTGCCTGCCTGCAGACCCTCGTG
CTGCACCAGTACTTCCACATCTGCTTCGTCAGTGGCATGAGGATCAAGACCGCTGTCATT
GGGGCTGTCTATCGGAAGGCCCTGGTGATCACCAATTCAGCCAGAAAATCCTCCACGGTC
GGGGAGATTGTCAACCTCATGTCTGTGGACGCTCAGAGGTTCATGGACTTGGCCACGTAC
ATTAACATGATCTGGTCAGCCCCCCTGCAAGTCATCCTTGCTCTCTACCTCCTGTGGCTG
AATCTGGGCCCTTCCGTCCTGGCTGGAGTGGCGGTGATGGTCCTCATGGTGCCCGTCAAT
GCTGTGATGGCGATGAAGACCAAGACGTATCAGGTGGCCCACATGAAGAGCAAAGACAAT
CGGATCAAGCTGATGAACGAAATTCTCAATGGGATCAAAGTGCTAAAGCTTTATGCCTGG
GAGCTGGCATTCAAGGACAAGGTGCTGGCCATCAGGCAGGAGGAGCTGAAGGTGCTGAAG
AAGTCTGCCTACCTGTCAGCCGTGGGCACCTTCACCTGGGTCTGCACGCCCTTTCTGGTG
GCCTTGTGCACATTTGCCGTCTACGTGACCATTGACGAGAACAACATCCTGGATGCCCAG
ACAGCCTTCGTGTCTTTGGCCTTGTTCAACATCCTCCGGTTTCCCCTGAACATTCTCCCC
ATGGTCATCAGCAGCATCGTGCAGGCGAGTGTCTCCCTCAAACGCCTGAGGATCTTTCTC
TCCCATGAGGAGCTGGAACCTGACAGCATCGAGCGACGGCCTGTCAAAGACGGCGGGGGC
ACGAACAGCATCACCGTGAGGAATGCCACATTCACCTGGGCCAGGAGCGACCCTCCCACA
CTGAATGGCATCACCTTCTCCATCCCCGAAGGTGCTTTGGTGGCCGTGGTGGGCCAGGTG
GGCTGCGGAAAGTCGTCCCTGCTCTCAGCCCTCTTGGCTGAGATGGACAAAGTGGAGGGG
CACGTGGCTATCAAGGGCTCCGTGGCCTATGTGCCACAGCAGGCCTGGATTCAGAATGAT
TCTCTCCGAGAAAACATCCTTTTTGGATGTCAGCTGGAGGAACCATATTACAGGTCCGTG
ATACAGGCCTGTGCCCTCCTCCCAGACCTGGAAATCCTGCCCAGTGGGGATCGGACAGAG
ATTGGCGAGAAGGGCGTGAACCTGTCTGGGGGCCAGAAGCAGCGCGTGAGCCTGGCCCGG
GCCGTGTACTCCAACGCTGACATTTACCTCTTCGATGATCCCCTCTCAGCAGTGGATGCC
CATGTGGGAAAACACATCTTTGAAAATGTGATTGGCCCCAAGGGGATGCTGAAGAACAAG
ACGCGGATCTTGGTCACGCACAGCATGAGCTACTTGCCGCAGGTGGACGTCATCATCGTC
ATGAGTGGCGGCAAGATCTCTGAGATGGGCTCCTACCAGGAGCTGCTGGCTCGAGACGGC
GCCTTCGCTGAGTTCCTGCGTACCTATGCCAGCACAGAGCAGGAGCAGGATGCAGAGGAG
AACGGGGTCACGGGCGTCAGCGGTCCAGGGAAGGAAGCAAAGCAAATGGAGAATGGCATG
CTGGTGACGGACAGTGCAGGGAAGCAACTGCAGAGACAGCTCAGCAGCTCCTCCTCCTAT
AGTGGGGACATCAGCAGGCACCACAACAGCACCGCAGAACTGCAGAAAGCTGAGGCCAAG
AAGGAGGAGACCTGGAAGCTGATGGAGGCTGACAAGGCGCAGACAGGGCAGGTCAAGCTT
TCCGTGTACTGGGACTACATGAAGGCCATCGGACTCTTCATCTCCTTCCTCAGCATCTTC
CTTTTCATGTGTAACCATGTGTCCGCGCTGGCTTCCAACTATTGGCTCAGCCTCTGGACT
GATGACCCCATCGTCAACGGGACTCAGGAGCACACGAAAGTCCGGCTGAGCGTCTATGGA
GCCCTGGGCATTTCACAAGGGATCGCCGTGTTTGGCTACTCCATGGCCGTGTCCATCGGG
GGGATCTTGGCTTCCCGCTGTCTGCACGTGGACCTGCTGCACAGCATCCTGCGGTCACCC
ATGAGCTTCTTTGAGCGGACCCCCAGTGGGAACCTGGTGAACCGCTTCTCCAAGGAGCTG
GACACAGTGGACTCCATGATCCCGGAGGTCATCAAGATGTTCATGGGCTCCCTGTTCAAC
GTCATTGGTGCCTGCATCGTTATCCTGCTGGCCACGCCCATCGCCGCCATCATCATCCCG
CCCCTTGGCCTCATCTACTTCTTCGTCCAGAGGTTCTACGTGGCTTCCTCCCGGCAGCTG
AAGCGCCTCGAGTCGGTCAGCCGCTCCCCGGTCTATTCCCATTTCAACGAGACCTTGCTG
GGGGTCAGCGTCATTCGAGCCTTCGAGGAGCAGGAGCGCTTCATCCACCAGAGTGACCTG
AAGGTGGACGAGAACCAGAAGGCCTATTACCCCAGCATCGTGGCCAACAGGTGGCTGGCC
GTGCGGCTGGAGTGTGTGGGCAACTGCATCGTTCTGTTTGCTGCCCTGTTTGCGGTGATC
TCCAGGCACAGCCTCAGTGCTGGCTTGGTGGGCCTCTCAGTGTCTTACTCATTGCAGGTC
ACCACGTACTTGAACTGGCTGGTTCGGATGTCATCTGAAATGGAAACCAACATCGTGGCC
GTGGAGAGGCTCAAGGAGTATTCAGAGACTGAGAAGGAGGCGCCCTGGCAAATCCAGGAG
ACAGCTCCGCCCAGCAGCTGGCCCCAGGTGGGCCGAGTGGAATTCCGGAACTACTGCCTG
CGCTACCGAGAGGACCTGGACTTCGTTCTCAGGCACATCAATGTCACGATCAATGGGGGA
GAAAAGGTCGGCATCGTGGGGCGGACGGGAGCTGGGAAGTCGTCCCTGACCCTGGGCTTA
TTTCGGATCAACGAGTCTGCCGAAGGAGAGATCATCATCGATGGCATCAACATCGCCAAG
ATCGGCCTGCACGACCTCCGCTTCAAGATCACCATCATCCCCCAGGACCCTGTTTTGTTT
TCGGGTTCCCTCCGAATGAACCTGGACCCATTCAGCCAGTACTCGGATGAAGAAGTCTGG
ACGTCCCTGGAGCTGGCCCACCTGAAGGACTTCGTGTCAGCCCTTCCTGACAAGCTAGAC
CATGAATGTGCAGAAGGCGGGGAGAACCTCAGTGTCGGGCAGCGCCAGCTTGTGTGCCTA
GCCCGGGCCCTGCTGAGGAAGACGAAGATCCTTGTGTTGGATGAGGCCACGGCAGCCGTG
GACCTGGAAACGGACGACCTCATCCAGTCCACCATCCGGACACAGTTCGAGGACTGCACC
GTCCTCACCATCGCCCACCGGCTCAACACCATCATGGACTACACAAGGGTGATCGTCTTG
GACAAAGGAGAAATCCAGGAGTACGGCGCCCCATCGGACCTCCTGCAGCAGAGAGGTCTT
TTCTACAGCATGGCCAAAGACGCCGGCTTGGTGTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
L05628

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_6_Locus:
16p13.1

# Macromolecular_Interacting_Partner_6_SNPs:
rs13337489; rs246221; rs8187863; rs35605; rs2301666; rs9933640; rs35587; rs8187853; rs2239330; rs8187858; rs16967004; rs212090; rs129081; rs3743527; rs2644983; rs215101; rs246240; rs35592; rs152022; rs152029; rs215059; rs2014800; rs903880; rs35591; rs1967120; rs246217; rs2283515; rs937369; rs215074; rs2239996; rs246220; rs129116; rs212081; rs35628; rs35597; rs875740; rs35604; rs2062541; rs215063; rs212082; rs212087; rs215094; rs246232; rs8050836; rs4148333; rs117854; rs246230; rs246228; rs212085; rs246234; rs215100; rs1964656; rs35588; rs11864374; rs4781711; rs3851710; rs11861115; rs7188722; rs35621; rs4780585; rs35607; rs4148366; rs9932506; rs7189813; rs11075296; rs212084; rs171583; rs924138; rs35589; rs7198841; rs2238475; rs7188937; rs246214; rs119774; rs6498594; rs8052419; rs215075; rs4148355; rs212089; rs3851718; rs215049; rs9933511; rs4781708; rs7187319; rs173476; rs35595; rs3887893; rs215105; rs35610; rs2889517; rs152030; rs7190484; rs8054670; rs3851712; rs35623; rs246226; rs7204081; rs11861085; rs9332430; rs4148343; rs3784867; rs246215; rs35596; rs215099; rs185005; rs8048316; rs2269800; rs8061136; rs7185286; rs215052; rs246219; rs2074086; rs4781712; rs246212; rs3851711; rs8059648; rs35620; rs11075293; rs193538; rs8054156; rs3784864; rs35629; rs3887412; rs3851719; rs6498591; rs11642957; rs246238; rs2384938; rs215098; rs12923345; rs8045309; rs1964657; rs16967126; rs3784862; rs12921748; rs246218; rs246222; rs215077; rs12934692; rs7404127; rs7188177; rs6498595; rs12445600; rs2283512; rs17501011; rs152032; rs4780589; rs8044115; rs17287570; rs215087; rs4148354; rs35625; rs9673292; rs17215768; rs35618; rs35594; rs2283516; rs17205859; rs11865361; rs4781699; rs7198766; rs452277; rs215088; rs246235; rs2384939; rs4780592; rs9932856; rs8047359; rs40427; rs35615; rs152027; rs215058; rs17501331; rs16967173; rs924135; rs6498597; rs35626; rs9932395; rs8049010; rs9932097; rs8053266; rs11861014; rs215096; rs8051963; rs17579406; rs2889518; rs11075291; rs4781727; rs35619; rs4780591; rs6498590; rs9635480; rs35606; rs152033; rs1153867; rs2074087; rs35601; rs152260; rs4781724; rs12921924; rs11075292; rs7203145; rs7196296; rs2238474; rs8048428; rs8054099; rs6498593; rs16967758; rs16967096; rs17265551; rs4781718; rs4148361; rs11861804; rs3851717; rs8058379; rs246241; rs11865571; rs16967145; rs215085; rs11866794; rs215066; rs1874001; rs16967227; rs11647513; rs7198932; rs903881; rs17264736; rs4148358; rs7189529; rs10852377; rs35627; rs11862504; rs2299670; rs182482; rs12924212; rs6498592; rs11075290; rs152028; rs152031; rs9938317; rs165975; rs8050637; rs7202970; rs12444264; rs4781716; rs7195031; rs12708802; rs2074085; rs215090; rs7197317; rs246236; rs11075289; rs35612; rs4148344; rs3851713; rs7201642; rs4780593; rs13332486; rs17579503; rs12921623; rs3888565; rs8187860; rs16967755; rs3765129; rs215086; rs4781701; rs924137; rs7196970; rs8048485; rs7201361; rs35614; rs7200100; rs3819552; rs12449241; rs6416665; rs11075295; rs11860247; rs35599; rs3216337; rs13335850; rs152023; rs35622; rs4148353; rs11861765; rs2644990; rs4148375; rs3844217; rs12922744; rs8055903; rs11645172; rs9923585; rs215091; rs7199424; rs215095; rs7193363; rs246229; rs7189316; rs11862407; rs9927099; rs4781709; rs12596469; rs215076; rs7196112; rs3851708; rs193537; rs7197383; rs16967179; rs9933152; rs9921168; rs16967046; rs3837750; rs3851716; rs248417; rs762775; rs1809815; rs4781700; rs12447386; rs215106; rs8056499; rs16955252; rs215053; rs8057422; rs215064; rs6498598; rs4781715; rs4148337; rs149541; rs4148346; rs762778; rs3784863; rs4148376; rs169984; rs11645782; rs2270490; rs12924026; rs7198391; rs8055510; rs17205838; rs215050; rs8058078; rs12927980; rs35602; rs11640751; rs246233; rs4781710; rs3888568; rs246223; rs456640; rs9931401; rs11075297; rs4148331; rs3851715; rs13331142; rs8059482; rs9927011; rs458926; rs8057596; rs12930197; rs215061; rs11866350; rs12929789; rs4148340; rs215054; rs3851709; rs215092; rs9933592; rs4781714; rs12922588; rs11863132; rs12447005; rs762777; rs11075288; rs35593; rs17841264; rs215079; rs4148351; rs152024; rs246213; rs215067; rs4148373; rs997691; rs215062; rs215051; rs215060; rs12927675; rs7198872; rs11861837; rs9928852; rs35616; rs4148335; rs13339242; rs9938526; rs10775291; rs215072; rs215089; rs35624; rs9931103; rs8057590; rs4781721; rs17205398; rs212079; rs8047227; rs7192281; rs8063599; rs215108; rs150530; rs4781720; rs1472532; rs35611; rs3932161; rs12446785; rs12922404; rs215055; rs8047871; rs215078; rs4781717; rs11865161; rs7193261; rs2283514; rs212083; rs169985; rs6498596; rs215103; rs246227; rs215057; rs17287542; rs4780586; rs937367; rs3784860; rs8062525; rs3851714; rs8058040; rs8059503; rs9934297; rs212088; rs13332140; rs35609; rs8047230; rs215068; rs212086; rs12599429; rs16966996; rs6498599; rs4780584; rs7198319; rs8046737; rs7186901; rs8053946; rs13335227; rs2644989; rs152025; rs35613; rs2283511; rs8046950; rs35600; rs4238623; rs4781722; rs4148362; rs11075298; rs13336889; rs4148336; rs12935283; rs215097; rs246237; rs924136; rs215056; rs4148349; rs11865349; rs35598; rs12449239; rs5016527; rs16967135; rs212080; rs8060750; rs2239995; rs4148359; rs215073; rs12447187; rs35590; rs6416666; rs7498870; rs9935678; rs12928602; rs7195815; rs3784861; rs10852378; rs7195962; rs11640684; rs9673916; rs35608; rs2238476; rs13333810; rs212091; rs4148380; rs504348; rs4148330; rs8056298; rs41395947; rs41410450; rs8057331; rs4148356; rs28706727; rs41494447; rs4148377; rs12596095; rs35840440; rs11647037; rs435683; rs7202416; rs36027088; rs2047591; rs8047497; rs28535049; rs36032323; rs35752420; rs7187052; rs3072717; rs28431874; rs34993915; rs34549440; rs12927511; rs34833276; rs12917894; rs13337533; rs35358180; rs10638507; rs9935219; rs35705679; rs10614463; rs9927479; rs4148363; rs13333388; rs7501384; rs4148371; rs4781728; rs12920011; rs35727154; rs11860365; rs28377922; rs12934657; rs35006643; rs28814960; rs12920817; rs5815853; rs215070; rs215065; rs35874442; rs5815856; rs11393636; rs10543560; rs33981753; rs35046517; rs4780588; rs5815852; rs34673924; rs35160852; rs6498601; rs28852806; rs34873364; rs4781707; rs10644540; rs9929609; rs13332722; rs2376956; rs34220492; rs35240096; rs28600754; rs11397057; rs3837749; rs4148368; rs12926867; rs12934266; rs9932205; rs35418200; rs35711628; rs12921067; rs35240251; rs28489119; rs13339669; rs35076831; rs13332852; rs165974; rs35241718; rs10438544; rs34334712; rs215080; rs13337581; rs34184710; rs12923217; rs35662370; rs34417580; rs28502346; rs11866942; rs11647533; rs28844882; rs34365293; rs8054963; rs10636969; rs9940699; rs393915; rs4479256; rs8055122; rs41278166; rs12920754; rs35229595; rs34555174; rs1108573; rs215109; rs13334390; rs12918259; rs34155371; rs35666498; rs11862552; rs10634703; rs11643934; rs34712007; rs4148364; rs12928233; rs11287273; rs12924449; rs12926589; rs10577554; rs11441919; rs10526186; rs7498869; rs35219631; rs34044736; rs12923333; rs35081755; rs34550012; rs35201502; rs10591001; rs215104; rs34485846; rs150529; rs4781719; rs11441920; rs7404359; rs12920923; rs35208396; rs9936158; rs11282335; rs34528514; rs34905861; rs2385154; rs35207136; rs5815854; rs35096356; rs35694522; rs4148369; rs7205368; rs10543561; rs35804420; rs7188711; rs35978240; rs28661219; rs11410221; rs8058069; rs7195265; rs9922649; rs35600720; rs12927259; rs246225; rs34275813; rs3837751; rs10712722; rs28662320; rs1690409; rs35090860; rs4646414; rs9933212; rs34159339; rs12447413; rs28710234; rs1690410; rs12935384; rs4148360; rs10694441; rs34530270; rs11373213; rs12443966; rs10656206; rs28393114; rs3072761; rs10673887; rs34085651; rs11427239; rs8062040; rs215048; rs34026115; rs9936155; rs33916796; rs35534532; rs5815850; rs34627014; rs34325137; rs11311843; rs34655471; rs34914361; rs34817873; rs35167276; rs11274450; rs4148350; rs11380982; rs34820524; rs34761300; rs35092337; rs410375; rs35694269; rs34630818; rs28753779; rs35490080; rs34313407; rs7192604; rs35086205; rs11277270; rs12933642; rs12925569; rs371941; rs35246390; rs12929025; rs35151447; rs35928400; rs35167165; rs28505554; rs35327998; rs5815857; rs34346901; rs7194547; rs36108316; rs11317464; rs34600200; rs34770208; rs246224; rs10673886; rs34123416; rs34383577; rs7498133; rs3851720; rs12934619; rs7193196; rs35525424; rs8062912; rs34982921; rs10555145; rs35254618; rs35193854; rs4115669; rs12926865; rs11640365; rs3080589; rs34334486; rs5815858; rs34479623; rs11325281; rs35126918; rs35367430; rs34868583; rs3072678; rs34536387; rs34557574; rs215069; rs12920474; rs12919829; rs34358165; rs28695591; rs9932986; rs34292006; rs35704526; rs35802304; rs35378917; rs34575102; rs12934210; rs12149248; rs246239; rs3072682; rs34897139; rs149320; rs34115753; rs7192845; rs4148347; rs9674124; rs8057769; rs11371659; rs35347382; rs11284065; rs8050655; rs34443742; rs17289179; rs12918323; rs35810367; rs11269394; rs35419413; rs35420214; rs34650655; rs35956116; rs34936105; rs35600994; rs6416667; rs12929024; rs12934905; rs17289158; rs28722680; rs2014793; rs1153866; rs12449077; rs34752935; rs3743526; rs35747063; rs34872698; rs8044628; rs35437608; rs11644918; rs4148348; rs12596360; rs35058919; rs4148332; rs34654774; rs41280868; rs10589853; rs36056963; rs10580146; rs11642737; rs10716039; rs7193755; rs152261; rs4520863; rs35609874; rs35869759; rs13329759; rs35851401; rs34074243; rs34575460; rs4148370; rs34490863; rs10532060; rs13334396; rs11327128; rs11343915; rs34482500; rs12917903; rs12934085; rs34466025; rs11639546; rs28592191; rs3830390; rs9923248; rs1690411; rs35471843; rs4780590; rs16967727; rs34789916; rs35133979; rs12934491; rs1874473; rs35983738; rs35101141; rs35252822; rs2283513; rs28501979; rs9889088; rs9929703; rs11323592; rs34788606; rs4459564; rs35384983; rs7193245; rs12934472; rs4646415; rs35685006; rs12927524; rs34005060; rs9931487; rs28515006; rs11647389; rs12050956; rs35692393; rs34742430; rs35708071; rs762776; rs13337279; rs5815855; rs34781067; rs35494993; rs35163690; rs41278168; rs12929883; rs13380679; rs7194549; rs35273939; rs12933311; rs28723466; rs490294; rs10706261; rs35493923; rs2384937; rs36080634; rs34754847; rs28561819; rs35605618; rs215102; rs7193525; rs34024385; rs4780594; rs28367505; rs11863228; rs13332325; rs11281850; rs12934805; rs8045000; rs4148367; rs5815851; rs6145768; rs10568708; rs35617; rs11644882; rs7202715; rs34870561; rs10673197; rs11320744; rs35791790; rs7196697; rs4497718; rs4148342; rs11416711; rs35962196; rs11304106; rs34692171; rs34935265; rs10598360; rs28735920; rs35603; rs6498600; rs215107; rs11416710; rs34985714; rs12925671; rs34292394; rs3072683; rs1697157; rs7205077; rs8064014; rs34714018; rs35601346; rs8058245; rs12232450; rs7199834; rs35481775; rs11430158; rs11291616; rs12930255; rs7197454; rs215093; rs28435381; rs34360190; rs8058920; rs4148378; rs28450757; rs35473382; rs4780587; rs10648689; rs416821; rs35118593; rs979560; rs34692126; rs7404210; rs11399369; rs12917672; rs4148365; rs34233722; rs28449253; rs34088403; rs34566056; rs11449114; rs35335689; rs34381428; rs34089889; rs12929977; rs11075299; rs12448760; rs16967632; rs212093; rs212094; rs212097; rs212098; rs2238473; rs28364001; rs28364002; rs34288338; rs34526519; rs34545444; rs35148086; rs35934123; rs35939983; rs3902401; rs4148382; rs6498603; rs7192634; rs8047642; rs8050881; rs8062278; rs8187843; rs8187844; rs8187845; rs8187846; rs8187848; rs8187849; rs8187850; rs8187851; rs8187854; rs8187855; rs8187856; rs8187857; rs8187859; rs8187861; rs8187862

# Macromolecular_Interacting_Partner_6_General_References:
1360704; 8098549; 8649356; 9344662; 10493829; 9295302; 9334225; 9485377; 11114332; 11469806; 11278867; 10835642; 10811882; 11721885; 11139250; 11266082

# Macromolecular_Interacting_Partner_6_References:
16784241; 16820223

# Macromolecular_Interacting_Partner_7_ID:
7029

# Macromolecular_Interacting_Partner_7_Name:
Glutaredoxin-1

# Macromolecular_Interacting_Partner_7_Synonyms:
Thioltransferase-1; TTase-1

# Macromolecular_Interacting_Partner_7_Gene_Name:
GLRX

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Glutaredoxin1
MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDY
LQQLTGARTVPRVFIGKDCIGGCSDLVSLQQSGELLTRLKQIGALQ

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
106

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
11776

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
8.21

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  transporter activity
Function:  electron transporter activity
 ||
>>>
Process:  homeostasis
Process:  cell homeostasis
Process:  cell redox homeostasis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Macromolecular_Interacting_Partner_7_Specific_Function:
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00462:Glutaredoxin

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
643695

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
GLRX1_HUMAN (P35754)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
GLRX

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
GLRX

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:4330

# Macromolecular_Interacting_Partner_7_PDB_ID:
1JHB

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>321 bp
ATGGCTCAAGAGTTTGTGAACTGCAAAATCCAGCCTGGGAAGGTGGTTGTGTTCATCAAG
CCCACCTGCCCGTACTGCAGGAGGGCCCAAGAGATCCTCAGTCAATTGCCCATCAAACAA
GGGCTTCTGGAATTTGTCGATATCACAGCCACCAACCACACTAACGAGATTCAAGATTAT
TTGCAACAGCTCACGGGAGCAAGAACGGTGCCTCGAGTCTTTATCGGTAAAGATTGTATA
GGCGGATGCAGTGATCTAGTCTCTTTGCAACAGAGTGGGGAACTCGTGACGCGGCTAAAG
CAGATTGGAGCTCTGCAGTAA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
D21238

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_7_Locus:
5q14

# Macromolecular_Interacting_Partner_7_SNPs:
rs4561; rs1047420; rs8751; rs6556883; rs8750; rs6877979; rs29000872; rs29000870; rs28926219; rs29000871; rs29000869; rs6890048; rs9314160; rs3822751; rs6875489; rs3777209; rs955688; rs28926201; rs28926206; rs11135435; rs28926199; rs28926209; rs28926196; rs28926210; rs11750758; rs28926769; rs10213972; rs28926212; rs28926211; rs12523440; rs28926204; rs10534384; rs28926202; rs2007; rs7700814; rs3756704; rs3756705; rs7701007; rs871775; rs6874678; rs10077489; rs17085147; rs17085130; rs17085133; rs17085131; rs28927968; rs28927970; rs17085143; rs28927971; rs28927976; rs28927969; rs28926194; rs28927977; rs9968751; rs29000874; rs29000875; rs28926191; rs28927973; rs34328253; rs4767; rs28926216; rs1047421; rs29000868; rs1047419; rs1047423; rs4869250; rs28926218; rs35375583; rs28926213; rs28926214; rs28926217; rs3842071; rs28926215; rs10531392; rs28926198; rs11373184; rs28926197; rs28926200; rs35096541; rs28926207; rs35347478; rs28926205; rs28926208; rs28926203; rs28926192; rs28927974; rs28927981; rs35243311; rs28927975; rs28927978; rs29000873; rs28926195; rs28926193; rs28927980; rs28927979; rs28927972; rs10065501; rs11135434; rs11135436; rs11745044; rs11747430; rs11949121; rs11953653; rs12109442; rs12513728; rs12518592; rs13173742; rs17085122; rs17085125; rs17085154; rs17085159; rs17462893; rs35008216; rs4869251; rs4993503; rs6556884; rs6556885; rs6556886; rs6871084; rs6876015; rs6894498; rs7700813; rs7726424; rs7736948; rs885303; rs889223; rs889224; rs889225; rs889226; rs9314158; rs959986; rs961164; rs9784598; rs9784676

# Macromolecular_Interacting_Partner_7_General_References:
8018729; 7851394; 8645179; 9332366; 8019414; 9677297; 9860827

# Macromolecular_Interacting_Partner_7_References:
16895798; 16962095; 17012768

# Macromolecular_Interacting_Partner_8_ID:
5759

# Macromolecular_Interacting_Partner_8_Name:
Glutamate--cysteine ligase catalytic subunit

# Macromolecular_Interacting_Partner_8_Synonyms:
Gamma- glutamylcysteine synthetase; Gamma-ECS; GCS heavy chain

# Macromolecular_Interacting_Partner_8_Gene_Name:
GCLC

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Glutamatecysteine ligase catalytic subunit
MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQ
EGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
QGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNS
YLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYS
LILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
637

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
72767

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
5.98

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  acid-amino acid ligase activity
Function:  glutamate-cysteine ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  cofactor metabolism
Process:  coenzyme metabolism
Process:  glutathione metabolism
Process:  glutathione biosynthesis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

# Macromolecular_Interacting_Partner_8_Pathway:
map00251  Glutamate metabolism;
 map00480  Glutathione metabolism

# Macromolecular_Interacting_Partner_8_Reaction:
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF03074:GCS

# Macromolecular_Interacting_Partner_8_Signals:
None

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
EC 6.3.2.2

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
183039

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
GSH1_HUMAN (P48506)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
GCLC

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
GCLC

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:4311

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1914 bp
ATGGGGCTGCTGTCCCAGGGCTCGCCGCTGAGCTGGGAGGAAACCAAGCGCCATGCCGAC
CACGTGCGGCGGCACGGGATCCTCCAGTTCCTGCACATCTACCACGCCGTCAAGGACCGG
CACAAGGACGTTCTCAAGTGGGGCGATGAGGTGGAATACATGTTGGTATCTTTTGATCAT
GAAAATAAAAAAGTCCGGTTGGTCCTGTCTGGGGAGAAAGTTCTTGAAACTCTGCAAGAG
AAGGGGGAAAGGACAAACCCAAACCATCCTACCCTTTGGAGACCAGAGTATGGGAGTTAC
ATGATTGAAGGGACACCAGGACAGCCCTACGGAGGAACAATGTCCGAGTTCAATACAGTT
GAGGCCAACATGCGAAAACGCCGGAAGGAGGCTACTTCTATATTAGAAGAAAATCAGGCT
CTTTGCACAATAACTTCATTTCCCAGATTAGGCTGTCCTGGGTTCACACTGCCCGAGGTC
AAACCCAACCCAGTGGAAGGAGGAGCTTCCAAGTCCCTCTTCTTTCCAGATGAAGCAATA
AACAAGCACCCTCGCTTCAGTACCTTAACAAGAAATATCCGACATAGGAGAGGAGAAAAG
GTTGTCATCAATGTACCAATATTTAAGGACAAGAATACACCATCTCCATTTATAGAAACA
TTTACTGAGGATGATGAAGCTTCAAGGGCTTCTAAGCCGGATCATATTTACATGGATGCC
ATGGGATTTGGAATGGGCAATTGCTGTCTCCAGGTGACATTCCAAGCCTGCAGTATATCT
GAGGCCAGATACCTTTATGATCAGTTGGCTACTATCTGTCCAATTGTTATGGCTTTGAGT
GCTGCATCTCCCTTTTACCGAGGCTATGTGTCAGACATTGATTGTCGCTGGGGAGTGATT
TCTGCATCTGTAGATGATAGAACTCGGGAGGAGCGAGGACTGGAGCCATTGAAGAACAAT
AACTATAGGATCAGTAAATCCCGATATGACTCAATAGACAGCTATTTATCTAAGTGTGGT
GAGAAATATAATGACATCGACTTGACGATAGATAAAGAGATCTACGAACAGCTGTTGCAG
GAAGGCATTGATCATCTCCTGGCCCAGCATGTTGCTCATCTCTTTATTAGAGACCCACTG
ACACTGTTTGAAGAGAAAATACACCTGGATGATGCTAATGAGTCTGACCATTTTGAGAAT
ATTCAGTCCACAAATTGGCAGACAATGAGATTTAAGCCCCCTCCTCCAAACTCAGACATT
GGATGGAGAGTAGAATTTCGACCCATGGAGGTGCAATTAACAGACTTTGAGAACTCTGCC
TATGTGGTGTTTGTGGTACTGCTCACCAGAGTGATCCTTTCCTACAAATTGGATTTTCTC
ATTCCACTGTCAAAGGTTGATGAGAACATGAAGGTAGCACAGAAAAGAGATGCTGTCTTG
CAGGGAATGTTTTATTTCAGGAAAGATATTTGCAAAGGTGGCAATGCAGTGGTGGATGGT
TGTGGCAAGGCCCAGAACAGCACGGAGCTCGCTGCAGAGGAGTACACCCTCATGAGCATA
GACACCATCATCAATGGGAAGGAAGGTGTGTTTCCTGGACTGATCCCAATTCTGAACTCT
TACCTTGAAAACATGGAAGTGGATGTGGACACCAGATGTAGTATTCTGAACTACCTAAAG
CTAATTAAGAAGAGAGCATCTGGAGAACTAATGACAGTTGCCAGATGGATGAGGGAGTTT
ATCGCAAACCATCCTGACTACAAGCAAGACAGTGTCATAACTGATGAAATGAATTATAGC
CTTATTTTGAAGTGTAACCAAATTGCAAATGAATTATGTGAATGCCCAGAGTTACTTGGA
TCAGCATTTAGGAAAGTAAAATATAGTGGAAGTAAAACTGACTCATCCAACTAG

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
M90656

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_8_Locus:
6p12

# Macromolecular_Interacting_Partner_8_SNPs:
Not Available

# Macromolecular_Interacting_Partner_8_General_References:
1350904; 14574404; 7726839; 10515893; 10733484

# Macromolecular_Interacting_Partner_8_References:
16769250; 16806086; 16958665

# Macromolecular_Interacting_Partner_9_ID:
5760

# Macromolecular_Interacting_Partner_9_Name:
Glutamate--cysteine ligase regulatory subunit

# Macromolecular_Interacting_Partner_9_Synonyms:
Gamma- glutamylcysteine synthetase; Gamma-ECS; GCS light chain; Glutamate--cysteine ligase modifier subunit

# Macromolecular_Interacting_Partner_9_Gene_Name:
GCLM

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Glutamatecysteine ligase regulatory subunit
MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINP
DLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVA
QLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQ
VKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIQAH
EWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
274

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
30727

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
5.91

# Macromolecular_Interacting_Partner_9_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

# Macromolecular_Interacting_Partner_9_Pathway:
map00251  Glutamate metabolism;
 map00480  Glutathione metabolism

# Macromolecular_Interacting_Partner_9_Reaction:
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Signals:
None

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
EC 6.3.2.2

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
530137

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
GSH0_HUMAN (P48507)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
GCLM

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
GCLM

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:4312

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>825 bp
ATGGGCACCGACAGCCGCGCGGCCAAGGCGCTCCTGGCGCGGGCCCGCACCCTGCACCTG
CAGACGGGGAACCTGCTGAACTGGGGCCGCCTGCGGAAGAAGTGCCCGTCCACGCACAGC
GAGGAGCTTCATGATTGTATCCAAAAAACCTTGAATGAATGGAGTTCCCAAATCAACCCA
GATTTGGTCAGGGAGTTTCCAGATGTCTTGGAATGCACTGTATCTCATGCAGTAGAAAAG
ATAAATCCTGATGAAAGAGAAGAAATGAAAGTTTCTGCAAAACTGTTCATTGTAGAATCA
AACTCTTCATCATCAACTAGAAGTGCAGTTGACATGGCCTGTTCAGTCCTTGGAGTTGCA
CAGCTGGATTCTGTGATCATTGCTTCACCTCCTATTGAAGATGGAGTTAATCTTTCCTTG
GAGCATTTACAGCCTTACTGGGAGGAATTAGAAAACTTAGTTCAGAGCAAAAAGATTGTT
GCCATAGGTACCTCTGATCTAGACAAAACACAGTTGGAACAGCTGTATCAGTGGGCACAG
GTAAAACCAAATAGTAACCAAGTTAATCTTGCCTCCTGCTGTGTGATGCCACCAGATTTG
ACTGCATTTGCTAAACAATTTGACATACAGCTGTTGACTCACAATGATCCAAAAGAACTG
CTTTCTGAAGCAAGTTTCCAAGAAGCTCTTCAGGAAAGCATTCCTGACATTCAAGCGCAC
GAGTGGGTGCCGCTGTGGCTACTGCGGTATTCGGTCATTGTGAAAAGTAGAGGAATTATC
AAATCAAAAGGCTACATTTTACAAGCTAAAAGAAGGGGTTCTTAA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
L35546

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_9_Locus:
1p22.1

# Macromolecular_Interacting_Partner_9_SNPs:
rs7549683; rs7513671; rs743119; rs17886277; rs17885307; rs17885169; rs17881908; rs17882741; rs718874; rs2301022; rs6700112; rs3827715; rs718875; rs6702045; rs7515813; rs6541405; rs10874809; rs6667121; rs7517826; rs6680315; rs6702064; rs6692306; rs7515191; rs11165031; rs718873; rs7515991; rs17885151; rs2064764; rs6703130; rs4598495; rs7541690; rs2273406; rs17886352; rs17376966; rs17879487; rs11165033; rs2234729; rs7552401; rs17885006; rs3838283; rs17886323; rs11292204; rs17882506; rs12094906; rs17878712; rs12040570; rs17881619; rs17879718; rs17878294; rs17882054; rs12068168; rs12057371; rs17882045; rs17878271; rs17879533; rs769211; rs10629524; rs11292206; rs17882036; rs17879467; rs17880826; rs17878538; rs17886750; rs12410324; rs2234730; rs7527855; rs11165032; rs17884788; rs17886306; rs17878275; rs17880957; rs17882277; rs12140446; rs17879190; rs17881810; rs3789453; rs17879495; rs17884538; rs2391323; rs12068345; rs3170633; rs17884708; rs10489605; rs10874808; rs12073535; rs41303970; rs17884327; rs1803635; rs17880087; rs12062047; rs1803636; rs35267053; rs17878410; rs17880076; rs12401915; rs17878517; rs17883607; rs34905252; rs17886946; rs17886856; rs12094966; rs17878333; rs17884809; rs12143416; rs12760946; rs17886844; rs35618697; rs17878692; rs17886976; rs12741834; rs17878765; rs17879789; rs7522297; rs11383482; rs3068846; rs17886656; rs11587480; rs12064127; rs12062214; rs12089163; rs17880726; rs12090038; rs12730517; rs10618137; rs34743713; rs17878940; rs17882664; rs2273407; rs34865905; rs17879276; rs17883701; rs17884701; rs17878450; rs11283634; rs12090230; rs17884925; rs17879344; rs17885227; rs17879710; rs17881946; rs17881704; rs33913648; rs17878956; rs17881873; rs17880789; rs34098452; rs17886292; rs11589165; rs17886490; rs17879292; rs12062216; rs35224592; rs17882171; rs35940482; rs17879340; rs17879254; rs17884580; rs34585952; rs17879576; rs17881957; rs11314452; rs17878727; rs17880908; rs17878443; rs11310647; rs17885147; rs17887188; rs41292675; rs17887214; rs17880917; rs34914684; rs34068353; rs11292205; rs34571118; rs17880905; rs17882290; rs35171651; rs34212520; rs6689857; rs34088596; rs35508812; rs5776197; rs11461316; rs736762; rs34049489; rs17881483; rs10874804; rs10874805; rs11165029; rs11165030; rs11808380; rs12080386; rs1802708; rs2235970; rs2235971; rs2391322; rs34270983; rs3761912; rs3789457; rs4141736; rs4141737; rs6675820; rs6681078; rs6687387; rs7533596

# Macromolecular_Interacting_Partner_9_General_References:
7826375

# Macromolecular_Interacting_Partner_9_References:
16769250; 16807751; 16939198; 16958665

End of HMDB00125

Beginning of HMDB00126
# Accession_No:
HMDB00126

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-24 11:35:55

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Glyceryl phosphate

# Description:
Glycerophosphoric acid is an example of a Glycerophospholipid. It was first artificially prepared in 1850 by French chemist Nicolas-Theodore Gobley from the hydrolysis of lecithin. A nitrogen-free class of lipids present in animal and particularly plant tissues and composed of one mole of glycerol and 1 or 2 mol of phosphatidic acid. Members of this group differ from one another in the nature of the fatty acids released on hydrolysis.

# Synonyms:
1-(dihydrogen phosphate) Glycerol; 1-(dihydrogen phosphate)Glycerol; 1-Glycerophosphate; 1-Glycerophosphorate; 1-Glycerophosphoric acid; 3-Glycerophosphate; DL-Glycerol 1-phosphate; DL-Glycerol 3-phosphate; DL-a-Glycerol phosphate; DL-a-Glycerophosphate; DL-a-Glycerophosphorate; DL-a-Glycerophosphoric acid; DL-a-Glyceryl phosphate; Glycerol 1-phosphate; Glycerol 3-phosphate; Glycerol a-phosphate; Glycerol mono; Glycerophosphorate; Glycerophosphoric acid; Glyceryl phosphate; Glyceryl phosphic acid; a-Glycerophosphate; a-Glycerophosphorate; a-Glycerophosphoric acid; a-Phosphoglycerol; dihydrogen a-glycerophosphate; DL-alpha-Glycerol phosphate; DL-alpha-Glycerophosphate; DL-alpha-Glycerophosphorate; DL-alpha-Glycerophosphoric acid; DL-alpha-Glyceryl phosphate; alpha-Glycerophosphate; alpha-Glycerophosphorate; alpha-Glycerophosphoric acid; alpha-Phosphoglycerol

# Chemical_IUPAC_Name:
1,2,3-Propanetriol, 1-(dihydrogen phosphate)

# Chemical_Formula:
C3H9O6P

# Chemical_Structure:
tbl_chemical:::HMDB00126_ZOOM.png:::11928320459313117

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00126_THUMB.png:::119283204436237470

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Alcohol Phosphates

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary alcohol; secondary alcohol; 1,2-diol; phosphoric acid ester

# Taxonomy_Biofunction:
Component of Glycerolipid metabolism; Component of Glycerophospholipid metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
172.01367

# Molecular_Weight_Avg:
172.07372

# Smiles_String_isomeric:
OC[C@@H](O)COP(O)(O)=O

# Smiles_String_canonical:
OCC(O)COP(O)(O)=O

# KEGG_Compound_ID:
C00093

# BioCyc_ID:
GLYCEROL-3P

# PubChem_CID:
439162

# PubChem_SID:
830628; 3393; 11533290; 855261; 10298225; 8145416; 855385; 820810; 823067; 820808; 820812

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
137383

# Wikipedia_ID:
Glycerol 3-phosphate

# METLIN_ID:
5161

# Ref_ID:
1639232; 134854

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
57-03-4

# InChI:
InChI=1/C3H9O6P/c4-1-3(5)2-9-10(6,7)8/h3-5H,1-2H2,(H2,6,7,8)/t3-/m1/s1

# Synthesis_Reference:
Enzymic synthesis of sn-glycerol 3-phosphate.     Rios-Mercadillo, Victor M.; Whitesides, George M.    Dep. Chem.,  Massachusetts Inst. Technol.,  Cambridge,  MA,  USA.    Journal of the American Chemical Society  (1979),  101(19),  5828-9.

# Melting_Point:
102-104oCC

# Melting_Point_predicted:
39.6 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1000.0 mg/mL [MERCK INDEX (1996)]

# H2O_Solubility_Predicted:
30.6 mg/mL [Predicted by ALOGPS]

# phys_charge:
-2

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-1.83 [Predicted by ALOGPS]; -3.1 [Predicted by PubChem via XLOGP]; -1.93 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00093.mol:::1132723808546209027

# SDF_File_[Text]:
tbl_chemical:::HMDB00126.sdf:::119283204133341519

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00126.pdb:::119283204300559559

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::050108_P00_10_IS_1DP_presat.png:::114781592656865025

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::050108_P00_10_IS_1DP_presat.zip:::114781535691461520

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::050108_P00_10_IS_1DP_Assigned.png:::115645346663628449

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041201_P07_23_BA_2DHSQC_1049.png:::114806993609677649

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041201_P07_23_BA_2DHSQC_1049.zip:::114806993610352650

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041201_P07_23_BA_2DHSQC_1049_Assigned.png:::115342497859227471

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Glyceryl phosphate.gif:::1132732111656844526

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00126_peaks.txt:::1156309561703786962

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Glyceryl phosphate_C.gif:::1132737692608494326

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00126_peaks.txt:::1156310751748907465

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000193.png:::116907444618775066

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000193.txt:::116907444618756593

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000193.png:::116890830814021176

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000193.txt:::116890830857860500

# Cellular_Location:
Cytoplasm; mitochondria

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Blood	30.0 +/- 3.0	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Not Available

# Pathway_Names:
Fructose and mannose metabolism;Glycolysis;Galactose metabolism;Aminosugars metabolism;Starch and sucrose metabolism;Streptomycin biosynthesis

# Pathway_Images:
fructose_metabolism.jpg;Glycolysis.jpg;;;;

# KEGG_Images:
map00051;map00010;map00052;map00530;map00500;map00521

# Pathway_Graphs:
fructose_metabolism_Graph.jpg;Glycolysis_Graph.jpg;;;;

# Pathway_SBMLs:
fructose_metabolism.xml;Glycolysis.xml;;;;

# Metabolic_Enzyme_1_ID:
6076

# Metabolic_Enzyme_1_Name:
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

# Metabolic_Enzyme_1_Synonyms:
6PF-2-K/Fru- 2,6-P2ASE brain/placenta-type isozyme; iPFK-2; Renal carcinoma antigen NY-REN-56[Includes: 6-phosphofructo-2-kinase

# Metabolic_Enzyme_1_Gene_Name:
PFKFB3

# Metabolic_Enzyme_1_Protein_Sequence:
>6phosphofructo2kinase/fructose2,6biphosphatase 3
MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLN
WIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQ
IAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNS
AEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLM
NIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQ
LKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTG
ESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKL
TPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFE
EHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKH

# Metabolic_Enzyme_1_Number_of_Residues:
520

# Metabolic_Enzyme_1_Molecular_Weight:
59610

# Metabolic_Enzyme_1_Theoretical_pI:
8.29

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  fructose metabolism
Process:  fructose 2,6-bisphosphate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Synthesis and degradation of fructose 2,6-bisphosphate

# Metabolic_Enzyme_1_Pathway:
map00051  Fructose and mannose metabolism

# Metabolic_Enzyme_1_Reaction:
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01591:6PF2K;
PF00300:PGAM

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.7.1.105;EC 3.1.3.46

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1468916

# Metabolic_Enzyme_1_SwissProt_ID:
F263_HUMAN (Q16875)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
PFKFB3

# Metabolic_Enzyme_1_Geneatlas_id:
PFKFB3

# Metabolic_Enzyme_1_hgnc_id:
HGNC:8874

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1563 bp
ATGCCGTTGGAACTGACGCAGAGCCGAGTGCAGAAGATCTGGGTGCCCGTGGACCACAGG
CCCTCGTTGCCCAGATCCTGTGGGCCAAAGCTGACCAACTCCCCCACCGTCATCGTCATG
GTGGGCCTCCCCGCCCGGGGCAAGACCTACATCTCCAAGAAGCTGACTCGCTACCTCAAC
TGGATTGGCGTCCCCACAAAAGTGTTCAACGTCGGGGAGTATCGCCGGGAGGCTGTGAAG
CAGTACAGCTCCTACAACTTCTTCCGCCCCGACAATGAGGAAGCCATGAAAGTCCGGAAG
CAATGTGCCTTAGCTGCCTTGAGAGATGTCAAAAGCTACCTGGCGAAAGAAGGGGGACAA
ATTGCGGTTTTCGATGCCACCAATACTACTAGAGAGAGGAGACACATGATCCTTCATTTT
GCCAAAGAAAATGACTTTAAAGCGTTTTTCATCGAGTCGGTGTGCGACGACCCTACAGTT
GTGGCCTCCAATATCATGGAAGTTAAAATCTCCAGCCCGGATTACAAAGACTGCAACTCG
GCAGAAGCCATGGACGACTTCATGAAGAGGATCAGTTGCTATGAAGCCAGCTACCAGCCC
CTCGACCCCGACAAATGCGACAGGGACTTGTCGCTGATCAAGGTGATTGACGTGGGCCGG
AGGTTCCTGGTGAACCGGGTGCAGGACCACATCCAGAGCCGCATCGTGTACTACCTGATG
AACATCCACGTGCAGCCGCGTACCATCTACCTGTGCCGGCACGGCGAGAACGAGCACAAC
CTCCAGGGCCGCATCGGGGGCGACTCAGGCCTGTCCAGCCGGGGCAAGAAGTTTGCCAGT
GCTCTGAGCAAGTTCGTGGAGGAGCAGAACCTGAAGGACCTGCGCGTGTGGACCAGCCAG
CTGAAGAGCACCATCCAGACGGCCGAGGCGCTGCGGCTGCCCTACGAGCAGTGGAAGGCG
CTCAATGAGATCGACGCGGGCGTCTGTGAGGAGCTGACCTACGAGGAGATCAGGGACACC
TACCCTGAGGAGTATGCGCTGCGGGAGCAGGACAAGTACTATTACCGCTACCCCACCGGG
GAGTCCTACCAGGACCTGGTCCAGCGCTTGGAGCCAGTGATCATGGAGCTGGAGCGGCAG
GAGAATGTGCTGGTCATCTGCCACCAGGCCGTCCTGCGCTGCCTGCTTGCCTACTTCCTG
GATAAGAGTGCAGAGGAGATGCCCTACCTGAAATGCCCTCTTCACACCGTCCTGAAACTG
ACGCCTGTCGCTTATGGCTGCCGTGTGGAATCCATCTACCTGAACGTGGAGTCCGTCTGC
ACACACCGGGAGAGGTCAGAGGATGCAAAGAAGGGACCTAACCCGCTCATGAGACGCAAT
AGTGTCACCCCGCTAGCCAGCCCCGAACCCACCAAAAAGCCTCGCATCAACAGCTTTGAG
GAGCATGTGGCCTCCACCTCGGCCGCCCTGCCCAGCTGCCTGCCCCCGGAGGTGCCCACG
CAGCTGCCTGGACAAAACATGAAAGGCTCCCGGAGCAGCGCTGACTCCTCCAGGAAACAC
TGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
D49817

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_1_Locus:
10p14-p15

# Metabolic_Enzyme_1_SNPs:
rs2230271; rs34714325; rs35877496; rs2230272; rs1539234; rs3750667; rs3829148; rs1064891; rs1539232; rs1539233; rs11596368; rs3750665; rs1064890; rs617245; rs2516614; rs756567; rs2794982; rs2794981; rs12357847; rs12255582; rs7071157; rs1557112; rs3793721; rs1557111; rs7904792; rs2516626; rs2073629; rs10737057; rs2765827; rs2298102; rs11813270; rs12412134; rs2516615; rs2104495; rs633733; rs9664762; rs943117; rs2516619; rs6602514; rs2148293; rs4750081; rs2148294; rs2516623; rs2516617; rs4747952; rs2516624; rs2182411; rs2148292; rs7915821; rs11257349; rs2765826; rs7915298; rs11817400; rs7896450; rs3838746; rs6602554; rs7898529; rs2148289; rs11595843; rs633835; rs11257456; rs11812743; rs11818646; rs2073628; rs2516616; rs2516622; rs11814534; rs2765824; rs7904794; rs7915327; rs17152229; rs11818596; rs10906032; rs947478; rs4750075; rs2182412; rs7924061; rs10466308; rs4747921; rs2148291; rs2251469; rs3793715; rs11593269; rs2794983; rs10466309; rs2516618; rs10906037; rs3838747; rs17152226; rs10906000; rs11812483; rs3793720; rs12571428; rs3829147; rs17152173; rs11257289; rs2148290; rs10906022; rs2516627; rs603973; rs11257470; rs11257472; rs3814192; rs672376; rs10795916; rs17136780; rs11815715; rs10795915; rs36005730; rs12569742; rs35413228; rs35117690; rs34832528; rs35050271; rs34184265; rs34969226; rs41291287; rs11257460; rs1064889; rs1064894; rs2387004; rs1064896; rs11541590; rs1064899; rs34059583; rs1064897; rs36102318; rs1064893; rs1064900; rs4002912; rs1064898; rs1064888; rs41291285; rs1064895; rs1064887; rs11541589; rs3814190; rs2387005; rs1064892; rs35781052; rs2516620; rs36134041; rs35364998; rs11257356; rs12357293; rs3083330; rs28532995; rs11816551; rs5782882; rs3083328; rs34773918; rs34860344; rs34889684; rs12764718; rs36107490; rs7902148; rs8181466; rs11593270; rs34514753; rs3216038; rs2516621; rs28699422; rs12267359; rs4750082; rs34128804; rs11257430; rs7907736; rs35009657; rs7082527; rs35995560; rs4747924; rs41306804; rs11257259; rs11816537; rs34794656; rs11257249; rs41291259; rs3084011; rs9424133; rs11257302; rs12572271; rs28391561; rs35881449; rs12769043; rs34000061; rs12359050; rs35987650; rs7898543; rs11257270; rs35890201; rs12780600; rs12783826; rs12779445; rs34821327; rs4237418; rs3793718; rs7903828; rs12249726; rs11257374; rs11257299; rs4747951; rs35193180; rs11816550; rs35512321; rs2025720; rs35531305; rs12779252; rs12358052; rs5782885; rs7894711; rs11257278; rs28605361; rs35426728; rs11257345; rs7921279; rs12360217; rs12259164; rs41291281; rs34235557; rs36147125; rs12359693; rs12572481; rs4237417; rs9424132; rs11257279; rs34276031; rs3829146; rs2516625; rs3084014; rs11257453; rs3833726; rs35617103; rs7895111; rs12770641; rs3084010; rs12775327; rs36070651; rs34569958; rs35618553; rs34836891; rs34819394; rs5782883; rs12259988; rs12571429; rs2242617; rs35532228; rs7895124; rs7894984; rs10906023; rs11591587; rs41310217; rs12764725; rs619797; rs35929982; rs34741388; rs28515908; rs34239981; rs34943779; rs35447462; rs34239137; rs35710132; rs35609333; rs5782881; rs7921003; rs12785005; rs7895104; rs5782884; rs12784609; rs12218519; rs12241169; rs12780995; rs41291275; rs1079445; rs11257234; rs11257229; rs1079446; rs11257235; rs34616071; rs35413444; rs17136787; rs10795869; rs10905976; rs11257188; rs11257192; rs11257200; rs11257206; rs11257482; rs11592813; rs11596852; rs11815773; rs12219292; rs12219678; rs12246508; rs12256901; rs12415582; rs12572467; rs12573050; rs17152391; rs17152396; rs17152400; rs17361911; rs4750160; rs4750166; rs637041; rs637452; rs681699; rs7076428; rs7085250; rs7092365; rs7894118; rs7894544; rs7916509; rs7916923; rs9733630

# Metabolic_Enzyme_1_General_References:
8830046; 10072580; 10077634; 10508479

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6077

# Metabolic_Enzyme_2_Name:
Mannose-6-phosphate isomerase

# Metabolic_Enzyme_2_Synonyms:
Phosphomannose isomerase; PMI; Phosphohexomutase

# Metabolic_Enzyme_2_Gene_Name:
MPI

# Metabolic_Enzyme_2_Protein_Sequence:
>Mannose6phosphate isomerase
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAK
ILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEK
LHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLK
QTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQ
LHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTP
KFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYK
VLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRAC
CLL

# Metabolic_Enzyme_2_Number_of_Residues:
423

# Metabolic_Enzyme_2_Molecular_Weight:
46656

# Metabolic_Enzyme_2_Theoretical_pI:
5.81

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  catalytic activity
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, interconverting aldoses and ketoses
Function:  mannose-6-phosphate isomerase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions

# Metabolic_Enzyme_2_Pathway:
map00051  Fructose and mannose metabolism

# Metabolic_Enzyme_2_Reaction:
D-mannose 6-phosphate = D-fructose 6-phosphate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01238:PMI_typeI

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 5.3.1.8

# Metabolic_Enzyme_2_GenBank_ID_Protein:
416017

# Metabolic_Enzyme_2_SwissProt_ID:
MANA_HUMAN (P34949)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
MPI

# Metabolic_Enzyme_2_Geneatlas_id:
MPI

# Metabolic_Enzyme_2_hgnc_id:
HGNC:7216

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm (Probable)

# Metabolic_Enzyme_2_Gene_Sequence:
>1272 bp
ATGGCCGCTCCGCGAGTATTCCCACTTTCCTGTGCGGTGCAGCAGTATGCCTGGGGGAAG
ATGGGTTCCAACAGCGAAGTGGCGCGGCTGTTGGCCAGCAGTGATCCACTGGCCCAGATC
GCAGAGGACAAGCCTTATGCAGAGTTGTGGATGGGGACTCACCCCCGAGGGGATGCCAAG
ATCCTTGACAACCGCATCTCACAGAAGACCCTAAGCCAGTGGATTGCTGAGAACCAGGAC
AGCTTGGGCTCAAAGGTCAAGGACACCTTTAATGGCAACCTGCCCTTCCTCTTCAAAGTG
CTCTCAGTTGAAACACCCCTGTCCATCCAGGCACACCCTAACAAGGAGCTGGCAGAGAAG
CTGCACCTCCAGGCTCCGCAGCACTACCCCGATGCCAACCACAAGCCAGAGATGGCCATT
GCCCTCACCCCCTTCCAGGGCTTGTGTGGCTTCCGGCCAGTTGAGGAGATTGTAACCTTT
CTAAAGAAGGTGCCTGAGTTTCAGTTCCTGATTGGAGATGAGGCAGCAACACACCTGAAG
CAGACCATGAGCCATGACTCCCAGGCTGTGGCCTCCTCTCTGCAGAGCTGTTTCTCCCAC
CTGATGAAGAGTGAGAAGAAGGTGGTGGTGGAACAGCTCAACCTGTTGGTGAAGCGGATC
TCCCAGCAAGCGGCTGCCGGAAACAACATGGAGGACATCTTTGGGGAGCTTTTGCTACAG
CTGCACCAGCAGTACCCAGGTGATATCGGCTGCTTTGCCATCTACTTCCTGAACCTGCTT
ACCCTGAAGCCTGGGGAGGCCATGTTTCTGGAGGCCAACGTACCCCATGCCTACCTGAAA
GGAGACTGCGTGGAGTGCATGGCGTGTTCAGACAACACAGTTCGTGCTGGCCTGACACCC
AAGTTCATTGATGTGCCAACCCTGTGTGAAATGCTCAGCTATACCCCTAGCTCCAGCAAG
GACAGGCTCTTTCTCCCAACACGGAGTCAGGAAGACCCCTACCTCTCAATCTATGACCCC
CCTGTACCAGACTTCACCATTATGAAGACGGAGGTCCCTGGCTCTGTCACTGAATACAAG
GTCTTGGCACTGGACTCTGCCAGCATCCTCCTGATGGTACAGGGGACAGTAATAGCCAGC
ACACCCACAACCCAGACACCAATCCCTCTGCAACGTGGTGGCGTGCTCTTCATTGGGGCC
AATGAGAGTGTCTCACTGAAGCTTACTGAGCCGAAGGACCTGCTGATATTCCGTGCCTGC
TGTCTGCTGTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X76057

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_2_Locus:
15q22-qter

# Metabolic_Enzyme_2_SNPs:
rs1130741; rs12440159; rs2230479; rs7495739; rs12593975; rs11633472; rs11638130; rs9673065; rs8031937; rs28928906; rs35672949; rs12913293; rs34940625; rs35459900; rs8032473; rs35210789; rs7497201; rs12915930; rs12915916; rs12914847; rs35087256; rs1127796; rs1127797; rs1128350; rs11856413; rs3935818; rs4886633; rs4886634; rs4886635; rs4886636; rs6495126; rs6495127; rs6495128; rs7497393

# Metabolic_Enzyme_2_General_References:
8307007; 10980531; 9585601; 9525984; 11350186; 12357336

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6078

# Metabolic_Enzyme_3_Name:
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

# Metabolic_Enzyme_3_Synonyms:
6PF-2-K/Fru- 2,6-P2ASE testis-type isozyme[Includes: 6-phosphofructo-2-kinase

# Metabolic_Enzyme_3_Gene_Name:
PFKFB4

# Metabolic_Enzyme_3_Protein_Sequence:
>6phosphofructo2kinase/fructose2,6biphosphatase 4
MASPRELTQNPLKKIWMPYSNGRPALHACQRGVCMTNCPTLIVMVGLPARGKTYISKKLT
RYLNWIGVPTREFNVGQYRRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSE
EGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYV
NRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVY
YLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVW
TSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALRDQDKYRYRY
PKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTV
LKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ

# Metabolic_Enzyme_3_Number_of_Residues:
469

# Metabolic_Enzyme_3_Molecular_Weight:
54040

# Metabolic_Enzyme_3_Theoretical_pI:
6.60

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  fructose metabolism
Process:  fructose 2,6-bisphosphate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Synthesis and degradation of fructose 2,6-bisphosphate

# Metabolic_Enzyme_3_Pathway:
map00051  Fructose and mannose metabolism

# Metabolic_Enzyme_3_Reaction:
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01591:6PF2K;
PF00300:PGAM

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.7.1.105;EC 3.1.3.46

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1905761

# Metabolic_Enzyme_3_SwissProt_ID:
F264_HUMAN (Q16877)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
PFKFB4

# Metabolic_Enzyme_3_Geneatlas_id:
PFKFB4

# Metabolic_Enzyme_3_hgnc_id:
HGNC:8875

# Metabolic_Enzyme_3_PDB_ID:
1BIF

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>1410 bp
ATGGCGTCCCCACGGGAATTGACACAGAACCCCCTGAAGAAGATCTGGATGCCATACAGC
AATGGGCGGCCCGCTCTGCACGCTTGCCAGCGCGGTGTGTGCATGACCAACTGCCCAACT
CTCATTGTCATGGTGGGCCTGCCCGCCAGGGGCAAGACCTACATCTCCAAGAAGCTGACT
CGATACCTGAACTGGATTGGTGTGCCCACTCGGGAGTTCAATGTTGGCCAGTACCGCCGG
GACGTGGTCAAGACCTACAAATCTTTTGAATTTTTTCTCCCCGACAATGAAGAGGGCCTG
AAAATCAGGAAGCAGTGTGCCCTGGCAGCCCTCCGTGACGTCCGGCGGTTCCTTAGTGAG
GAGGGGGGACATGTGGCGGTTTTTGATGCCACAAACACCACCCGAGAACGGAGAGCGACC
ATCTTTAATTTTGGAGAACAGAATGGCTACAAGACCTTTTTTGTCGAGTCCATCTGTGTG
GATCCTGAGGTCATAGCTGCCAACATCGTGCAAGTGAAACTGGGCAGCCCTGACTATGTC
AACCGCGACAGTGATGAGGCTACGGAGGACTTCATGAGGCGCATTGAGTGCTATGAGAAC
TCCTACGAGTCGCTAGATGAGGACCTGGATAGGGACCTGTCCTATATCAAGATCATGGAT
GTGGGCCAGAGCTACGTGGTGAACCGTGTGGCTGACCACATCCAGAGCCGCATCGTATAT
TACCTCATGAACATCCACGTGACCCCCCGCTCCATCTACCTCTGCCGGCACGGGGAGAGC
GAGCTCAACCTCAAGGGCCGGATTGGCGGGGACCCAGGACTGTCCCCTCGGGGCAGGGAG
TTTGCCAAGAGTCTAGCCCAGTTCATCAGTGACCAAAATATCAAGGATCTGAAGGTCTGG
ACAAGCCAGATGAAGAGGACAATCCAGACGGCTGAGGCACTGGGTGTGCCCTATGAACAG
TGGAAGGTCCTCAACGAGATCGATGCGGGCGTCTGTGAGGAAATGACCTACGAGGAAATT
CAGGATAATTATCCACTGGAGTTCGCCCTGCGGGACCAGGACAAGTACCGGTACCGGTAC
CCTAAAGGGGAGTCCTACGAGGACCTGGTCCAGAGACTGGAGCCTGTCATCATGGAGCTG
GAGAGGCAAGAGAATGTGCTGGTCATCTGCCACCAGGCTGTGATGCGCTGCCTGCTGGCC
TACTTCCTCGACAAGGCAGCAGAACAGCTGCCCTACCTCAAGTGTCCGCTGCACACAGTC
CTGAAGCTGACTCCTGTGGCATATGGTTGTAAAGTGGAGTCCATATTCCTGAACGTGGCT
GCTGTGAACACGCACCGGGACAGGCCTCAGAACGTGGACATCTCAAGACCTCCAGAGGAA
GCCCTTGTCACGGTGCCTGCTCACCAGTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
D49818

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_3_Locus:
3p22-p21

# Metabolic_Enzyme_3_SNPs:
rs13094578; rs4075800; rs3969942; rs2267846; rs2109181; rs6806059; rs9882962; rs2006871; rs9810991; rs11710798; rs6762888; rs9837687; rs9810549; rs6792525; rs6787988; rs7629120; rs2267844; rs9869698; rs28563843; rs9848824; rs13079292; rs9850102; rs7615170; rs9864729; rs9862906; rs9849280; rs13091944; rs4075082; rs3755818; rs3755819; rs1128386; rs35588032; rs9810411; rs35464719; rs751872; rs28391653; rs10470687; rs34924009; rs7631971; rs9682142; rs9809913; rs10633208; rs7615003; rs34004437; rs10621650; rs6791436; rs11718623; rs9871948; rs35201801; rs41290682; rs9917656; rs35726698; rs7622623; rs34961329; rs35325884; rs11709994; rs3831738; rs34817026; rs9853054; rs35452137; rs7611499; rs11328976; rs5848854; rs28789805; rs7434048; rs4858822; rs6791419; rs2098101; rs758602; rs6774589; rs7612601; rs34769393; rs35368418; rs10619156; rs34746110; rs35230500; rs13069446; rs766363; rs13069677; rs11348081; rs35614822; rs2267845; rs10711617; rs34199659; rs36002554; rs35975361; rs1042469; rs11710189; rs13066396; rs13319635; rs13319651; rs1803298; rs2633965; rs423561; rs754917; rs9835827; rs9839959; rs9856504; rs9866124

# Metabolic_Enzyme_3_General_References:
10095107; 8830046

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5403

# Metabolic_Enzyme_4_Name:
Dimethylaniline monooxygenase [N-oxide-forming] 3

# Metabolic_Enzyme_4_Synonyms:
Hepatic flavin-containing monooxygenase 3; FMO 3; Dimethylaniline oxidase 3; FMO form 2; FMO II

# Metabolic_Enzyme_4_Gene_Name:
FMO3

# Metabolic_Enzyme_4_Protein_Sequence:
>Dimethylaniline monooxygenase Noxideforming 3
MGKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKFSDHAEEGRASIYKSVFS
NSSKEMMCFPDFPFPDDFPNFMHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKHPDFA
TTGQWDVTTERDGKKESAVFDAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPG
VFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVWDNGYPWDMLLVTRFG
TFLKNNLPTAISDWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVK
PNVKEFTETSAIFEDGTIFEGIDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPL
LEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPSMEDMMNDINEKMEKKRKWF
GKSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQWP
GARNAILTQWDRSLKPMQTRVVGRLQKPCFFFHWLKLFAIPILLIAVFLVLT

# Metabolic_Enzyme_4_Number_of_Residues:
532

# Metabolic_Enzyme_4_Molecular_Weight:
60034

# Metabolic_Enzyme_4_Theoretical_pI:
7.87

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  disulfide oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen
Function:  dimethylaniline monooxygenase (N-oxide-forming) activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  cell
Component:  cell fraction
Component:  membrane fraction
Component:  vesicular fraction
Component:  microsome

# Metabolic_Enzyme_4_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Acts on TMA to produce TMA-N-oxide

# Metabolic_Enzyme_4_Pathway:
Not Available

# Metabolic_Enzyme_4_Reaction:
N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00743:FMO-like

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
509-531

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.14.13.8

# Metabolic_Enzyme_4_GenBank_ID_Protein:
188631

# Metabolic_Enzyme_4_SwissProt_ID:
FMO3_HUMAN (P31513)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
FMO3

# Metabolic_Enzyme_4_Geneatlas_id:
FMO3

# Metabolic_Enzyme_4_hgnc_id:
HGNC:3771

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Microsome

# Metabolic_Enzyme_4_Gene_Sequence:
>1602 bp
ATGGGGAAGAAAGTGGCCATCATTGGAGCTGGTGTGAGTGGCTTGGCCTCCATCAGGAGC
TGTCTGGAAGAGGGGCTGGAGCCCACCTGCTTTGAGAAGAGCAATGACATTGGGGGCCTG
TGGAAATTTTCAGACCATGCAGAGGAGGGCAGGGCTAGCATTTACAAATCAGTCTTTTCC
AACTCTTCCAAAGAGATGATGTGTTTCCCAGACTTCCCATTTCCCGATGACTTCCCCAAC
TTTATGCACAACAGCAAGATCCAGGAATATATCATTGCATTTGCCAAAGAAAAGAACCTC
CTGAAGTACATACAATTTAAGACATTTGTATCCAGTGTAAATAAACATCCTGATTTTGCA
ACTACTGGCCAGTGGGATGTTACCACTGAAAGGGATGGTAAAAAAGAATCGGCTGTCTTT
GATGCTGTAATGGTTTGTTCCGGACATCATGTGTATCCCAACCTACCAAAAAAGTCCTTT
CCAGGACTAAACCACTTTAAAGGCAAATGCTTCCACAGCAGGGACTATAAAGAACCAGGT
GTATTCAATGGAAAGCGTGTCCTGGTGGTTGGCCTGGGGAATTCGGGCTGTGATATTGCC
ACAGAACTCAGCCGCACAGCAGAACAGGTCATGATCAGTTCCAGAAGTGGCTCCTGGGTG
ATGAGCCGGGTCTGGGACAATGGTTATCCTTGGGACATGCTGCTCGTCACTCGATTTGGA
ACCTTCCTCAAGAACAATTTACCGACAGCCATCTCTGACTGGTTGTACGTGAAGCAGATG
AATGCAAGATTCAAGCATGAAAACTATGGCTTGATGCCTTTAAATGGAGTCCTGAGGAAA
GAGCCTGTATTTAACGATGAGCTCCCAGCAAGCATTCTGTGTGGCATTGTGACCGTAAAG
CCTAACGTGAAGGAATTCACAGAGACCTCGGCCATTTTTGAGGATGGGACCATATTTGAG
GGCATTGACTGTGTAATCTTTGCAACAGGGTATAGTTTTGCCTACCCCTTCCTTGATGAG
TCTATCATCAAAAGCAGAAACAATGAGATCATTTTATTTAAAGGAGTATTTCCTCCTCTA
CTTGAGAAGTCAACCATAGCAGTATTGGGCTTTGTCCAGTCCCTTGGGGCTGCCATTCCC
ACAGTTGACCTCCAGTCCCGCTGGGCAGCACAAGTAATAAAGGGAACTTGTACTTTGGGC
CCTTTCTATGGGAAGACATTGATGAATGATATTATTGAGAAAATGGAGAAAAAGCGGGCA
AATGGGTTTGGCAAAAGCGAGACCATACAGACAGATTACATTGTTTATATGGATGAACTC
TCCTCCTTCATTGGGGCAACCAACATCCCAATGCTGTTCCTCACAGGTCCCAAATTGGCC
ATGGAGTTATTTGGGCCCTGTAGTCCCTACCAGTTTAGGCTGGTGGGCCCAGGCAGCTGG
CCAGGAGCCAGAAATGCCATACTGACCCAGTGGGACCGGTCGTTGAAACCCATGCAGACA
CGAGTGGTCGGGAGACTTCAGAAGCCTTGCTTCTTTTTCCATTGGCTGAAGCTCTTTGCA
ATTCCTATTCTGTTAATCGCTGTTTTCCTTGTGTTGACCTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M83772

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_4_Locus:
1q23-q25

# Metabolic_Enzyme_4_SNPs:
rs2266782; rs1736557; rs2266780; rs2066532; rs2066530; rs12072582; rs909530; rs1800822; rs28363595; rs7880493; rs1736561; rs11578281; rs28363524; rs28363522; rs7060320; rs7880204; rs7881612; rs28363523; rs1920149; rs2236873; rs1736559; rs1736556; rs2064075; rs2066534; rs909531; rs2075992; rs7061710; rs10797894; rs7062331; rs1736566; rs6608462; rs909529; rs1080197; rs2236872; rs2281002; rs2066537; rs909532; rs10797877; rs12405599; rs2235192; rs6608463; rs10911192; rs7051320; rs2064076; rs12403297; rs16864050; rs2066529; rs16864066; rs17564980; rs10797878; rs10911238; rs2064074; rs16864042; rs12406572; rs16828308; rs1072255; rs12076145; rs4140653; rs3832023; rs10911320; rs28745588; rs28363552; rs2204791; rs28363530; rs28363589; rs2066528; rs28745584; rs28363570; rs2205725; rs28363593; rs28363539; rs28363564; rs28363536; rs28363557; rs28363537; rs28363543; rs12085248; rs28363562; rs28363528; rs28363544; rs28363527; rs28745580; rs1983550; rs2204790; rs28363535; rs28363591; rs12404455; rs28363560; rs28363551; rs1795239; rs28363583; rs28363533; rs28745585; rs28363571; rs28363553; rs12059956; rs28363541; rs28363578; rs28745589; rs28745592; rs7886526; rs28745579; rs28363563; rs28363558; rs28363588; rs12072717; rs28745582; rs1920137; rs28745581; rs28363545; rs28363575; rs28745593; rs28363542; rs28363550; rs28363540; rs28363526; rs28363584; rs28745591; rs28745586; rs12073562; rs28363590; rs28363554; rs1736555; rs16864006; rs7052352; rs1736560; rs16864007; rs12404183; rs1736554; rs1736558; rs3754487; rs12404218; rs17564210; rs3754489; rs28363513; rs12070707; rs28363597; rs28363515; rs12066527; rs28363596; rs3754491; rs28363549; rs28363581; rs1050906; rs2066536; rs28363546; rs1050902; rs35525949; rs28363521; rs10600742; rs36034922; rs10636613; rs33958279; rs10594148; rs11383160; rs41272509; rs28363520; rs35849478; rs12732215; rs12074448; rs28363566; rs28363547; rs28363559; rs28363532; rs2204793; rs28363569; rs28745590; rs28363579; rs28363580; rs11578651; rs28363577; rs12072547; rs28363586; rs11320098; rs28363572; rs7471289; rs28363585; rs35194229; rs35650903; rs34063190; rs34947289; rs28363555; rs1795248; rs11579293; rs35810404; rs28363525; rs28363582; rs28817873; rs28363576; rs34247334; rs28745578; rs11317520; rs2066531; rs36106873; rs28810082; rs12074485; rs28363567; rs28363531; rs28363538; rs28363574; rs28363587; rs12078163; rs28817425; rs28363565; rs5778693; rs28745583; rs28809513; rs28363592; rs28363529; rs35625940; rs28363561; rs28363594; rs35802574; rs35463008; rs28363534; rs28363568; rs28363556; rs11580161; rs7473127; rs34143632; rs3980650; rs28363573; rs28745587; rs35892452; rs28866833; rs28363516; rs11385180; rs28363514; rs35949891; rs28363518; rs34913672; rs28363517; rs28363519; rs7880894; rs11449828; rs10910879; rs10911641; rs10911664; rs10911694; rs11809504; rs12086786; rs12089338; rs12118296; rs12402295; rs12402693; rs16863987; rs16863989; rs17350502; rs1795240; rs4607926; rs6608459; rs6608461; rs7060028; rs7060055; rs7062329; rs742057; rs742058; rs7474070; rs7474265; rs9970392; rs9970495

# Metabolic_Enzyme_4_General_References:
1542660; 8654418; 9417913; 9536088; 10338091; 10479479; 12527699

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
6037

# Metabolic_Enzyme_5_Name:
6-phosphofructokinase, muscle type

# Metabolic_Enzyme_5_Synonyms:
Phosphofructokinase 1; Phosphohexokinase; Phosphofructo-1-kinase isozyme A; PFK-A; Phosphofructokinase-M

# Metabolic_Enzyme_5_Gene_Name:
PFKM

# Metabolic_Enzyme_5_Protein_Sequence:
>6phosphofructokinase, muscle type
MTHEEHHAAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVD
GGDHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDG
SLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDS
ALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWE
EHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQ
RGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTK
AMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRPPVSKSGSHTVAVMNVGAPAAGMNAAVR
STVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQ
ISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSV
GADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPF
TIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLG
HMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVF
QPVAELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKRSGEAAV


# Metabolic_Enzyme_5_Number_of_Residues:
780

# Metabolic_Enzyme_5_Molecular_Weight:
85184

# Metabolic_Enzyme_5_Theoretical_pI:
8.07

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  phosphofructokinase activity
Function:  6-phosphofructokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  protein complex
Component:  6-phosphofructokinase complex
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_5_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

# Metabolic_Enzyme_5_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00030  Pentose phosphate pathway;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism

# Metabolic_Enzyme_5_Reaction:
ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00365:PFK

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.7.1.11

# Metabolic_Enzyme_5_GenBank_ID_Protein:
1101758

# Metabolic_Enzyme_5_SwissProt_ID:
K6PF_HUMAN (P08237)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
PFKM

# Metabolic_Enzyme_5_Geneatlas_id:
PFKM

# Metabolic_Enzyme_5_hgnc_id:
HGNC:8877

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Not Available

# Metabolic_Enzyme_5_Gene_Sequence:
>2343 bp
ATGACCCATGAAGAGCACCATGCAGCCAAAACCCTGGGGATTGGCAAAGCCATTGCTGTC
TTAACCTCTGGTGGAGATGCCCAAGGTATGAATGCTGCTGTCAGGGCTGTGGTTCGAGTT
GGTATCTTCACCGGTGCCCGTGTCTTCTTTGTCCATGAGGGTTATCAAGGCCTGGTGGAT
GGTGGAGATCACATCAAGGAAGCCACCTGGGAGAGCGTTTCGATGATGCTTCAGCTGGGA
GGCACGGTGATTGGAAGTGCCCGGTGCAAGGACTTTCGGGAACGAGAAGGACGACTCCGA
GCTGCCTACAACCTGGTGAAGCGTGGGATCACCAATCTCTGTGTCATTGGGGGTGATGGC
AGCCTCACTGGGGCTGACACCTTCCGTTCTGAGTGGAGTGACTTGTTGAGTGACCTCCAG
AAAGCAGGTAAGATCACAGATGAGGAGGCTACGAAGTCCAGCTACCTGAACATTGTGGGC
CTGGTTGGGTCAATTGACAATGACTTCTGTGGCACTGATATGACCATTGGCACTGACTCT
GCCCTGCATCGGATCATGGAAATTGTAGATGCCATCACTACCACTGCCCAGAGCCACCAG
AGGACATTTGTGTTAGAAGTAATGGGCCGCCACTGTGGATACCTGGCCCTTGTCACCTCT
CTGTCCTGTGGGGCCGACTGGGTTTTTATTCCTGAATGTCCACCAGATGACGACTGGGAG
GAACACCTTTGTCGCCGACTCAGCGAGACAAGGACCCGTGGTTCTCGTCTCAACATCATC
ATTGTGGCTGAGGGTGCAATTGACAAGAATGGAAAACCAATCACCTCAGAAGACATCAAG
AATCTGGTGGTTAAGCGTCTGGGATATGACACCCGGGTTACTGTCTTGGGGCATGTGCAG
AGGGGTGGGACGCCATCAGCCTTTGACAGAATTCTGGGCAGCAGGATGGGTGTGGAAGCA
GTGATGGCACTTTTGGAGGGGACCCCAGATACCCCAGCCTGTGTAGTGAGCCTCTCTGGT
AACCAGGCTGTGCGCCTGCCCCTCATGGAATGTGTCCAGGTGACCAAAGATGTGACCAAG
GCCATGGATGAGAAGAAATTTGACGAAGCCCTGAAGCTGAGAGGCCGGAGCTTCATGAAC
AACTGGGAGGTGTACAAGCTTCTAGCTCATGTCAGACCCCCGGTATCTAAGAGTGGTTCG
CACACAGTGGCTGTGATGAACGTGGGGGCTCCGGCTGCAGGCATGAATGCTGCTGTTCGC
TCCACTGTGAGGATTGGCCTTATCCAGGGCAACCGAGTGCTCGTTGTCCATGATGGTTTC
GAGGGCCTGGCCAAGGGGCAGATAGAGGAAGCTGGCTGGAGCTATGTTGGGGGCTGGACT
GGCCAAGGTGGCTCTAAACTTGGGACTAAAAGGACTCTACCCAAGAAGAGCTTTGAACAG
ATCAGTGCCAATATAACTAAGTTTAACATTCAGGGCCTTGTCATCATTGGGGGCTTTGAG
GCTTACACAGGGGGCCTGGAACTGATGGAGGGCAGGAAGCAGTTTGATGAGCTCTGCATC
CCATTTGTGGTCATTCCTGCTACAGTCTCCAACAATGTCCCTGGCTCAGACTTCAGCGTT
GGGGCTGACACAGCACTCAATACTATCTGCACAACCTGTGACCGCATCAAGCAGTCAGCA
GCTGGCACCAAGCGTCGGGTGTTTATCATTGAGACTATGGGTGGCTACTGTGGCTACCTG
GCTACCATGGCTGGACTGGCAGCTGGGGCCGATGCTGCCTACATTTTTGAGGAGCCCTTC
ACCATTCGAGACCTGCAGGCAAATGTTGAACATCTGGTGCAAAAGATGAAAACAACTGTG
AAAAGGGGCTTGGTGTTAAGGAATGAAAAGTGCAATGAGAACTATACCACTGACTTCATT
TTCAACCTGTACTCTGAGGAGGGGAAGGGCATCTTCGACAGCAGGAAGAATGTGCTTGGT
CACATGCAGCAGGGTGGGAGCCCAACCCCATTTGATAGGAATTTTGCCACTAAGATGGGC
GCCAAGGCTATGAACTGGATGTCTGGGAAAATCAAAGAGAGTTACCGTAATGGGCGGATC
TTTGCCAATACTCCAGATTCGGGCTGTGTTCTGGGGATGCGTAAGAGGGCTCTGGTCTTC
CAACCAGTGGCTGAGCTGAAGGACCAGACAGATTTTGAGCATCGAATCCCCAAGGAACAG
TGGTGGCTGAAACTGAGGCCCATCCTCAAAATCCTAGCCAAGTACGAGATTGACTTGGAC
ACTTCAGACCATGCCCACCTGGAGCACATCACCCGGAAGCGGTCCGGGGAAGCTGCCGTC
TAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M59741

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_5_Locus:
12q13.3

# Metabolic_Enzyme_5_SNPs:
rs2228500; rs8716; rs1049392; rs1859445; rs1476607; rs4760685; rs4075913; rs2286020; rs4760684; rs10875747; rs2286021; rs11168421; rs10082861; rs4141065; rs2269933; rs10875749; rs10875746; rs12304251; rs10219645; rs11168424; rs11168423; rs7484648; rs10875748; rs11168427; rs11830546; rs11168425; rs10219623; rs11168419; rs4760683; rs10875745; rs11168417; rs2269935; rs11168418; rs11168420; rs11552506; rs41291965; rs12828446; rs41291971; rs12826853; rs12317430; rs41290390; rs11552507; rs14683; rs3189641; rs8977; rs35847394; rs11374838; rs34737106; rs12817932; rs41291969; rs12826678; rs34747961; rs34241029; rs36015571; rs3989535; rs11168422; rs11609979; rs12826680; rs34700912; rs33914383; rs7978674; rs41291963; rs7301375; rs12831427; rs41291961; rs41291967; rs34996435; rs34207745; rs4075914; rs35651820; rs11835145; rs7133146; rs10219520; rs10783230; rs10875750; rs11168413; rs11168414; rs11168428; rs11608670; rs12297470; rs12310813; rs12422786; rs12579815; rs1802781; rs3936179; rs4760682; rs4760686; rs7302354; rs7485355; rs7488265; rs8804

# Metabolic_Enzyme_5_General_References:
1833270; 2526045; 2822475; 2140567; 2526044; 7550225; 7513946; 7825568; 8889589

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
6033

# Metabolic_Enzyme_6_Name:
6-phosphofructokinase, liver type

# Metabolic_Enzyme_6_Synonyms:
Phosphofructokinase 1; Phosphohexokinase; Phosphofructo-1-kinase isozyme B; PFK-B

# Metabolic_Enzyme_6_Gene_Name:
PFKL

# Metabolic_Enzyme_6_Protein_Sequence:
>6phosphofructokinase, liver type
MAAVDLEKLRASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVE
GGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDG
SLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDS
ALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWE
NFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQ
RGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQK
AMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRS
AVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESI
VENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLG
SDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFN
IHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGH
LQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFS
PVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQYRISMAAYVSGELEHVTRRTLSMDKGF


# Metabolic_Enzyme_6_Number_of_Residues:
780

# Metabolic_Enzyme_6_Molecular_Weight:
85020

# Metabolic_Enzyme_6_Theoretical_pI:
7.54

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  phosphofructokinase activity
Function:  6-phosphofructokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  protein complex
Component:  6-phosphofructokinase complex
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_6_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

# Metabolic_Enzyme_6_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00030  Pentose phosphate pathway;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism

# Metabolic_Enzyme_6_Reaction:
ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00365:PFK

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.7.1.11

# Metabolic_Enzyme_6_GenBank_ID_Protein:
35431

# Metabolic_Enzyme_6_SwissProt_ID:
K6PL_HUMAN (P17858)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
PFKL

# Metabolic_Enzyme_6_Geneatlas_id:
PFKL

# Metabolic_Enzyme_6_hgnc_id:
HGNC:8876

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>2343 bp
ATGGCCGCGGTGGACCTGGAGAAGCTGCGGGCGTCGGGCGCGGGCAAGGCCATCGGCGTC
CTGACCAGCGGCGGCGACCGGCAAGGCATGAACGCTGCTGTCCGGGCTGTGACGCGCATG
GGCATTTATGTGGGTGCCAAAGTCTTCCTCATCTACGAGGGCTATGAGGGCCTCGTGGAG
GGAGGTGAGAACATCAAGCAGGCCAACTGGCTGAGCGTCTCCAACATCATCCAGCTGGGC
GGCACTATCATTGGCAGCGCTCGCTCGAAGGCCTTTACCACCAGGGAGGGGCGCCGGGCA
GCGGCCTACAACCTGGTCCAGCACGGCATCACCAACCTGTGCGTCATCGGCGGGGATGGC
AGCCTCACAGGTGCCAACATCTTCCGCAGCGAGTGGGGCAGCCTGCTGGAGGAGCTGGTG
GCGGAAGGTAAGATCTCAGAGACTACAGCCTGGACCTACTCGCACCTGAACATCGCGGGC
CTAGTGGGCTCCATCGATAACGACTTCTGCGGCACCGACATGACCATCGGCACGGACTCG
GCCCTCCACCGCATCATGGAGGTCATCGATGCCATCACCACCACTGCCCAGAGCCACCAG
AGGACCTTCGTGCTGGAAGTGATGGGCCGGCACTGCGGGTACCTGGCGCTGGTATCTGCA
CTGGCCTCAGGGGCCGACTGGCTGTTCATCCCCGAGGCTCCACCCGAGGACGGCTGGGAG
AACTTCATGTGTGAGAGGCTGGGTGAGACTCGGAGCCGTGGGTCCCGACTGAACATCATC
ATCATCGCTGAGGGTGCCATTGACCGCAACGGGAAGCCCATCTCGTCCAGCTACGTGAAG
GACCTGGTGGTTCAGAGGCTGGGCTTCGACACCCGTGTAACTGTGCTGGGCCACGTGCAG
CGGGGAGGGACGCCCTCTGCCTTCGACCGGATCCTGAGCAGCAAGATGGGCATGGAGGCG
GTGATGGCGCTGCTGGAAGCCACGCCTGACACGCCGGCCTGCGTGGTCACCCTCTCGGGG
AACCAGTCAGTGCGGCTGCCCCTCATGGAGTGCGTGCAGATGACCAAGGAAGTGCAGAAA
GCCATGGATGACAAGAGGTTTGACGAGGCCACCCAGCTCCGTGGTGGGAGCTTCGAGAAC
AACTGGAACATTTACAAGCTCCTCACCCACCAGAAGCCCCCCAAGGAGAAGTCTAACTTC
TCCCTGGCCATCCTGAATGTGGGGGCCCCGGCGGCTGGCATGAATGCGGCCGTGCGCTCG
GCGGTGCGGACCGGCATCTCCCATGGACACACAGTATACGTGGTGCACGATGGCTTCGAA
GGCCTAGCCAAGGGTCAGGTGCAAGAAGTAGGCTGGCACGACGTGGCCGGCTGGTTGGGG
CGTGGTGGCTCCATGCTGGGGACCAAGAGGACCCTGCCCAAGGGCCAGCTGGAGTCCATT
GTGGAGAACATCCGCATCTATGGTATTCACGCCCTGCTGGTGGTCGGTGGGTTTGAGGCC
TATGAAGGGGTGCTGCAGCTGGTGGAGGCTCGCGGGCGCTACGAGGAGCTCTGCATCGTC
ATGTGTGTCATCCCAGCCACCATCAGCAACAACGTCCCTGGCACCGACTTCAGCCTGGGC
TCCGACACTGCTGTAAATGCCGCCATGGAGAGCTGTGACCGCATCAAACAGTCTGCCTCG
GGGACCAAGCGCCGTGTGTTCATCGTGGAGACCATGGGGGGTTACTGTGGCTACCTGGCC
ACCGTGACTGGCATTGCTGTGGGGGCCGACGCCGCCTACGTCTTCGAGGACCCTTTCAAC
ATCCACGACTTAAAGGTCAACGTGGAGCACATGACGGAGAAGATGAAGACAGACATTCAG
AGGGGCCTGGTGCTGCGGAACGAGAAGTGCCATGACTACTACACCACGGAGTTCCTGTAC
AACCTGTACTCATCAGAGGGCAAGGGCGTCTTCGACTGCAGGACCAATGTCCTGGGCCAC
CTGCAGCAGGGTGGCGCTCCAACCCCCTTTGACCGGAACTATGGGACCAAGCTGGGGGTG
AAGGCCATGCTGTGGTTGTCGGAGAAGCTGCGCGAGGTTTACCGCAAGGGACGGGTGTTC
GCCAATGCCCCAGACTCGGCCTGCGTGATCGGCCTGAAGAAGAAGGCGGTGGCCTTCAGC
CCCGTCACTGAGCTCAAGAAAGACACTGATTTCGAGCACCGCATGCCACGGGAGCAGTGG
TGGCTGAGCCTGCGGCTCATGCTGAAGATGCTGGCACAATACCGCATCAGTATGGCCGCC
TACGTGTCAGGGGAGCTGGAGCACGTGACCCGCCGCACCCTGAGCATGGACAAGGGCTTC
TGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
X15573

# Metabolic_Enzyme_6_Chromosome_Location:
Not Available

# Metabolic_Enzyme_6_Locus:
Not Available

# Metabolic_Enzyme_6_SNPs:
rs1057037; rs9975113; rs1057034; rs2838545; rs2838544; rs2236669; rs3788115; rs8134520; rs7282369; rs8129937; rs4350841; rs3788116; rs7277792; rs2039274; rs9975994; rs1893208; rs2073436; rs2236670; rs9984426; rs7283094; rs3788117; rs3788114; rs9976073; rs9975988; rs9982262; rs9979367; rs9979369; rs9983978; rs2838550; rs2070568; rs8133730; rs3827256; rs2838549; rs2243542; rs7279267; rs2838548; rs2070569; rs2838547; rs11088947; rs2838546; rs2070571; rs928303; rs2250238; rs4818905; rs1972269; rs11909786; rs2277808; rs2776382; rs8127589; rs4818904; rs2070570; rs2276250; rs2847231; rs2876959; rs743484; rs12483184; rs2847229; rs743481; rs12483238; rs17004643; rs11908697; rs4818907; rs9977591; rs9981333; rs12482540; rs2276249; rs2276251; rs12482028; rs743483; rs2070567; rs9306096; rs2847230; rs1972267; rs9974877; rs2298692; rs1972268; rs9975413; rs4818906; rs10460741; rs9975207; rs11558848; rs11558850; rs17850433; rs17855402; rs9974772; rs9980790; rs11700493; rs34577649; rs1057222; rs3831402; rs35664594; rs2039275; rs1057197; rs8129860; rs9637179; rs8130111; rs11558849; rs35382076; rs34642010; rs9981255; rs34391295; rs34562056; rs35580361; rs34634869; rs3788120; rs34012756; rs743487; rs34319533; rs11269292; rs8133214; rs34875847; rs743486; rs9974934; rs35541329; rs35458462; rs743485; rs35890279; rs34330261; rs762425; rs3788118; rs12483015; rs34114410; rs17276063; rs9974264; rs13433407; rs743482; rs34915720; rs34644431; rs34835108; rs9975069; rs9306097; rs35213117; rs35820150; rs34193517; rs9975195; rs35158995; rs2741986; rs2741987; rs2850170; rs5844182; rs9975203; rs35045753; rs1003854; rs1056687; rs1056689; rs1056725; rs11552066; rs11552067; rs11911657; rs12627511; rs15145; rs1800521; rs1800522; rs1800524; rs1800525; rs1800526; rs2070573; rs2073610; rs2073611; rs2075877; rs2075878; rs2236441; rs2256817; rs2277809; rs2741985; rs2847225; rs3746965; rs3746966; rs3761392; rs3761393; rs3788113; rs4818709; rs4818710; rs760426; rs760427; rs933150; rs941405; rs9976610

# Metabolic_Enzyme_6_General_References:
2533063; 2139864; 10830953; 12665801

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5443

# Metabolic_Enzyme_7_Name:
Glucosamine-6-phosphate isomerase

# Metabolic_Enzyme_7_Synonyms:
Glucosamine-6- phosphate deaminase; GNPDA; GlcN6P deaminase; Oscillin

# Metabolic_Enzyme_7_Gene_Name:
GNPDA1

# Metabolic_Enzyme_7_Protein_Sequence:
>Glucosamine6phosphate isomerase
MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGD
LSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDA
FEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTK
VPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCD
EDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKEKETEKSQSSKKPYSD

# Metabolic_Enzyme_7_Number_of_Residues:
289

# Metabolic_Enzyme_7_Molecular_Weight:
32669

# Metabolic_Enzyme_7_Theoretical_pI:
6.91

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, interconverting aldoses and ketoses
Function:  glucosamine-6-phosphate deaminase activity
 ||
>>>
Process:  nitrogen compound metabolism
Process:  amine metabolism
Process:  amino sugar metabolism
Process:  glucosamine metabolism
Process:  N-acetylglucosamine metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3)

# Metabolic_Enzyme_7_Pathway:
map00530  Aminosugars metabolism

# Metabolic_Enzyme_7_Reaction:
D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + ammonia

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF01182:Glucosamine_iso

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.5.99.6

# Metabolic_Enzyme_7_GenBank_ID_Protein:
2935438

# Metabolic_Enzyme_7_SwissProt_ID:
GNPI_HUMAN (P46926)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
GNPDA1

# Metabolic_Enzyme_7_Geneatlas_id:
GNPDA1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:4417

# Metabolic_Enzyme_7_PDB_ID:
1NE7

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_7_Gene_Sequence:
>870 bp
ATGAAGCTCATCATCCTGGAGCACTATTCTCAGGCGAGCGAGTGGGCGGCTAAATACATC
AGGAACCGTATCATCCAGTTTAACCCAGGGCCAGAGAAGTACTTCACCCTGGGGCTCCCC
ACTGGGAGTACCCCACTTGGCTGCTACAAGAAGCTGATTGAATACTATAAGAATGGGGAC
CTGTCCTTTAAATATGTGAAGACCTTCAACATGGATGAGTACGTGGGCCTTCCTCGAGAC
CACCCGGAGAGTTACCACTCCTTCATGTGGAACAACTTCTTCAAGCACATTGACATCCAC
CCAGAAAACACCCACATTCTGGATGGGAATGCAGTCGACCTACAGGCAGAATGTGATGCC
TTTGAAGAGAAGATCAAGGCTGCAGGTGGGATCGAGCTATTTGTTGGAGGCATCGGCCCT
GATGGACACATTGCCTTCAACGAGCCAGGCTCCAGTCTGGTGTCCAGGACCCGTGTGAAG
ACGCTGGCCATGGATACCATCCTGGCCAATGCTAGGTTCTTCGATGGAGAACTCACCAAG
GTGCCCACCATGGCCTTGACGGTGGGGGTGGGCACTGTCATGGATGCTAGAGAGGTGATG
ATCCTTATCACAGGTGCTCACAAGGCATTTGCTCTGTACAAGGCCATCGAGGAGGGAGTG
AACCACATGTGGACCGTGTCTGCCTTCCAGCAGCATCCCCGCACCGTGTTTGTGTGTGAC
GAGGATGCCACCTTGGAGCTGAAAGTGAAGACTGTCAAGTATTTCAAAGGTTTAATGCTT
GTTCATAACAAGTTGGTGGACCCCTTGTACAGTATCAAAGAGAAAGAAACTGAGAAAAGC
CAATCTTCGAAGAAACCATACAGCGATTAG

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AF048826

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_7_Locus:
5q21

# Metabolic_Enzyme_7_SNPs:
rs164080; rs7408; rs252120; rs2232193; rs252115; rs252111; rs252114; rs2232196; rs252112; rs1898679; rs252119; rs10214150; rs108593; rs351251; rs11746455; rs252118; rs252113; rs252117; rs7730740; rs252123; rs6887699; rs644639; rs252125; rs379285; rs252124; rs17524593; rs164501; rs644683; rs252122; rs428205; rs420547; rs11557800; rs2232198; rs1802147; rs1804084; rs2232192; rs11557799; rs4623179; rs35979770; rs449560; rs2232201; rs13175480; rs28672679; rs35914330; rs10628648; rs7708455; rs2232197; rs1134940; rs9986308; rs35408304; rs2232199; rs2232200; rs36114825; rs2232195; rs2232194; rs7733407; rs252094; rs189500; rs34467154; rs35952167; rs13187511; rs34537521; rs252116; rs41339846; rs3045628; rs35395011; rs426964; rs34709199; rs370150; rs12187204; rs11400936; rs6862017; rs6883498; rs13180040; rs164500; rs379553; rs33940540; rs12658433; rs10078983; rs153146; rs163920; rs164081; rs164498; rs164499; rs168331; rs252091; rs33992487; rs34476681; rs347525; rs366749; rs369592; rs379784; rs3910558; rs392582; rs403075; rs418921; rs439466; rs4912790; rs6580215; rs661944; rs665400

# Metabolic_Enzyme_7_General_References:
9438414; 7584044

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
6079

# Metabolic_Enzyme_8_Name:
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

# Metabolic_Enzyme_8_Synonyms:
6PF-2-K/Fru- 2,6-P2ASE liver isozyme[Includes: 6-phosphofructo-2-kinase

# Metabolic_Enzyme_8_Gene_Name:
PFKFB1

# Metabolic_Enzyme_8_Protein_Sequence:
>6phosphofructo2kinase/fructose2,6biphosphatase 1
MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYIST
KLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYL
SHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPD
YIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRT
VYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLK
VWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRY
RYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLH
TVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY

# Metabolic_Enzyme_8_Number_of_Residues:
471

# Metabolic_Enzyme_8_Molecular_Weight:
54682

# Metabolic_Enzyme_8_Theoretical_pI:
6.56

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  fructose metabolism
Process:  fructose 2,6-bisphosphate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Synthesis and degradation of fructose 2,6-bisphosphate

# Metabolic_Enzyme_8_Pathway:
map00051  Fructose and mannose metabolism

# Metabolic_Enzyme_8_Reaction:
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF01591:6PF2K;
PF00300:PGAM

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.7.1.105;EC 3.1.3.46

# Metabolic_Enzyme_8_GenBank_ID_Protein:
35503

# Metabolic_Enzyme_8_SwissProt_ID:
F261_HUMAN (P16118)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
PFKFB1

# Metabolic_Enzyme_8_Geneatlas_id:
PFKFB1

# Metabolic_Enzyme_8_hgnc_id:
HGNC:8872

# Metabolic_Enzyme_8_PDB_ID:
1K6M

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Not Available

# Metabolic_Enzyme_8_Gene_Sequence:
>1416 bp
ATGTCTCCAGAGATGGGAGAGCTCACCCAAACCAGGTTGCAGAAGATCTGGATTCCACAC
AGCAGCGGCAGCAGCAGGCTGCAACGGAGAAGGGGCTCATCCATACCCCAGTTTACCAAT
TCCCCCACAATGGTGATCATGGTGGGTTTACCAGCTCGAGGCAAGACCTATATCTCCACA
AAGCTCACACGATATCTCAACTGGATAGGAACACCAACTAAAGTGTTTAATTTAGGCCAG
TATCGACGAGAGGCAGTGAGCTACAAGAACTATGAATTCTTTCTTCCAGACAACATGGAA
GCCCTGCAAATCAGGAAGCAGTGCGCCCTGGCAGCCCTGAAGGATGTTCACAACTATCTC
AGCCATGAGGAAGGTCATGTTGCGGTTTTTGATGCCACCAACACTACCAGAGAACGACGG
TCACTGATCCTGCAGTTTGCAAAAGAACATGGTTACAAGGTGTTTTTCATTGAGTCCATT
TGTAATGACCCTGGCATAATTGCAGAAAACATCAGGCAAGTGAAACTTGGCAGCCCTGAT
TATATAGACTGTGACCGGGAAAAGGTTCTGGAAGACTTTCTAAAGAGAATTGAGTGCTAT
GAGGTCAACTACCAACCCTTGGATGAGGAACTGGACAGCCACCTGTCCTACATCAAGATC
TTCGACGTGGGCACACGCTACATGGTGAACCGAGTGCAGGATCACATCCAGAGCCGCACA
GTCTACTACCTCATGAATATCCATGTCACACCTCGCTCCATCTACCTTTGCCGACATGGC
GAGAGTGAACTCAACATCAGAGGCCGCATCGGAGGTGACTCTGGCCTCTCAGTTCGCGGC
AAGCAGTATGCCTATGCCCTGGCCAACTTCATTCAGTCCCAGGGCATCAGCTCCCTGAAG
GTGTGGACCAGTCGCATGAAGAGGACCATCCAGACAGCTGAGGCCCTGGGTGTCCCCTAT
GAGCAGTGGAAGGCCCTGAATGAGATTGATGCGGGTGTCTGTGAGGAGATGACCTATGAA
GAAATCCAGGAACATTACCCTGAAGAATTTGCACTGCGAGACCAAGATAAATATCGCTAC
CGCTATCCCAAGGGAGAGTCCTATGAGGATCTGGTTCAGCGTCTGGAGCCAGTGATAATG
GAGCTAGAACGACAGGAGAATGTACTGGTGATCTGCCACCAGGCTGTCATGCGGTGCCTC
CTGGCCTATTTCCTGGATAAAAGTTCAGATGAGCTTCCATATCTCAAGTGCCCTCTGCAC
ACAGTGCTCAAACTCACTCCTGTGGCTTATGGCTGCAAAGTGGAATCCATCTACCTGAAT
GTGGAGGCCGTGAACACACACCGGGAGAAGCCTGAGAATGTGGACATCACCCGGGAACCT
GAGGAAGCCCTGGATACTGTCCCAGCCCACTACTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X52638

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_8_Locus:
Xp11.21

# Metabolic_Enzyme_8_SNPs:
rs2885192; rs2005463; rs7054008; rs12009826; rs4826364; rs12013180; rs7055550; rs7876830; rs3765479; rs7884892; rs12006688; rs6521221; rs7877193; rs4592165; rs12010055; rs12009992; rs12014660; rs7050286; rs4826365; rs6521220; rs742049; rs12392887; rs12007444; rs12009010; rs6611392; rs5960384; rs6612244; rs12012208; rs7055905; rs1122799; rs12014943; rs7058302; rs7058322; rs7058927; rs6612249; rs5914242; rs1042227; rs34371591; rs5960058; rs36040294; rs36000310; rs6611394; rs6611393; rs41300640; rs12171770; rs5960059; rs11423589; rs4421487; rs35672261; rs35602727; rs11396018; rs11396019; rs35995915; rs34911422; rs3028350; rs35636472; rs41306753; rs5960383; rs34428777; rs5960057; rs12842941; rs6612245; rs35611718; rs34224076; rs34971789; rs6612246; rs12844500; rs6651976; rs1054247; rs6612247; rs12389586; rs34692314; rs5902532; rs12834442; rs41306890; rs34059559; rs35766066; rs35051444; rs12006936; rs34676173; rs34539636; rs36018524; rs34913653; rs5960382; rs41300642; rs34339145; rs34442347; rs5902531; rs12836233; rs5914243; rs12862038; rs35325903; rs34995115; rs12171767; rs12833908; rs5960056; rs34495378; rs13440561; rs13440562; rs10218054; rs35134458; rs1008681; rs10284089; rs1050010; rs1050011; rs12851962; rs1811845; rs1883158; rs2273138; rs2301416; rs2301417; rs3180303; rs3180304; rs4490972; rs4826363; rs5960055; rs7059574; rs7062848; rs7889977; rs7891167

# Metabolic_Enzyme_8_General_References:
2163524; 2837207

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5445

# Metabolic_Enzyme_9_Name:
Hexokinase-2

# Metabolic_Enzyme_9_Synonyms:
Hexokinase type II; HK II; Muscle form hexokinase

# Metabolic_Enzyme_9_Gene_Name:
HK2

# Metabolic_Enzyme_9_Protein_Sequence:
>Hexokinase2
MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAA
VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMR
GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV
EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYME
EMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGM
YMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLG
LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKH
PHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLS
HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV
LLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF
TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG
TMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD
FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG
IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA
VVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKG
AALITAVACRIREAGQR

# Metabolic_Enzyme_9_Number_of_Residues:
917

# Metabolic_Enzyme_9_Molecular_Weight:
102381

# Metabolic_Enzyme_9_Theoretical_pI:
5.93

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_9_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism;
 map00521  Streptomycin biosynthesis;
 map00530  Aminosugars metabolism

# Metabolic_Enzyme_9_Reaction:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00349:Hexokinase_1;
PF03727:Hexokinase_2

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.7.1.1

# Metabolic_Enzyme_9_GenBank_ID_Protein:
587202

# Metabolic_Enzyme_9_SwissProt_ID:
HXK2_HUMAN (P52789)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
HK2

# Metabolic_Enzyme_9_Geneatlas_id:
HK2

# Metabolic_Enzyme_9_hgnc_id:
HGNC:4923

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding (By similarity)

# Metabolic_Enzyme_9_Gene_Sequence:
>2754 bp
ATGATTGCCTCGCATCTGCTTGCCTACTTCTTCACGGAGCTCAACCATGACCAAGTGCAG
AAGGTTGACCAGTATCTCTACCACATGCGCCTCTCTGATGAGACCCTCTTGGAGATCTCT
AAGCGGTTCCGCAAGGAGATGGAGAAAGGGCTTGGAGCCACCACTCACCCTACTGCAGCA
GTGAAGATGCTGCCCACCTTTGTGAGGTCCACTCCAGATGGGACAGAACACGGAGAGTTC
CTGGCTCTGGATCTTGGAGGGACCAACTTCCGTGTGCTTTGGGTGAAAGTAACGGACAAT
GGGCTCCAGAAGGTGGAGATGGAGAATCAGATCTATGCCATCCCTGAGGACATCATGCGA
GGCAGTGGCACCCAGCTGTTTGACCACATTGCCGAATGCCTGGCTAACTTCATGGATAAG
CTACAAATCAAAGACAAGAAGCTCCCACTGGGTTTTACCTTCTCGTTCCCCTGCCACCAG
ACTAAACTAGACGAGAGTTTCCTGGTCTCATGGACCAAGGGATTCAAGTCCAGTGGAGTG
GAAGGCAGAGACGTTGTGGCTCTGATCCGGAAGGCCATCCAGAGGAGAGGGGACTTTGAT
ATCGACATTGTGGCTGTGGTGAATGACACAGTTGGGACCATGATGACCTGTGGTTATGAT
GACCACAACTGTGAGATTGGTCTCATTGTGGGCACGGGCAGCAACGCCTGCTACATGGAA
GAGATGCGCCACATCGACATGGTGGAAGGCGATGAGGGGCGGATGTGTATCAATATGGAG
TGGGGGGCCTTCGGGGACGATGGCTCGCTCAACGACATTCGCACTGAGTTTGACCAGGAG
ATTGACATGGGCTCACTGAACCCGGGAAAGCAACTGTTTGAGAAGATGATCAGTGGGATG
TACATGGGGGAGCTGGTGAGGCTTATCCTGGTGAAGATGGCCAAGGAGGAGCTGCTCTTT
GGGGGGAAGCTCAGCCCAGAGCTTCTCAACACCGGTCGCTTTGAGACCAAAGACATCTCA
GACATTGAAGGGGAGAAGGATGGCATCCGGAAGGCCCGTGAGGTCCTGATGCGGTTGGGC
CTGGACCCGACTCAGGAGGACTGCGTGGCCACTCACCGGATCTGCCAGATCGTGTCCACA
CGCTCCGCCAGCCTGTGCGCAGCCACCCTGGCCGCCGTGCTGCAGCGCATCAAGGAGAAC
AAAGGCGAGGAGCGGCTGCGCTCTACTATTGGGGTCGACGGTTCCGTCTACAAGAAACAC
CCCCATTTTGCCAAGCGTCTACATAAGACCGTGCGGCGGCTGGTGCCCGGCTGCGATGTC
CGCTTCCTCCGCTCCGAGGATGGCAGTGGCAAAGGTGCAGCCATGGTGACAGCAGTGGCT
TACCGGCTGGCCGATCAACACCGTGCCCGCCAGAAGACATTAGAGCATCTGCAGCTGAGC
CATGACCAGCTGCTGGAGGTCAAGAGGAGGATGAAGGTAGAAATGGAGCGAGGTCTGAGC
AAGGAGACTCATGCCAGTGCCCCCGTCAAGATGCTGCCCACCTACGTGTGTGCTACCCCG
GACGGCACAGAGAAAGGGGACTTCTTGGCCTTGGACCTTGGAGGAACAAATTTCCGGGTC
CTGCTGGTCCGTGTTCGGAATGGGAAGTGGGGTGGAGTGGAGATGCACAACAAGATCTAC
GCCATCCCGCAGGAGGTCATGCACGGCACCGGGGACGAGCTCTTTGACCACATTGTCCAG
TGCATCGCGGACTTCCTCGAGTACATGGGCATGAAGGGCGTGTCCCTGCCTCTGGGTTTT
ACCTTCTCCTTCCCCTGCCAGCAGAACAGCCTGGACGAGAGCATCCTCCTCAAGTGGACA
AAAGGCTTCAAGGCATCTGGCTGCGAGGGCGAGGACGTGGTGACCCTGCTGAAGGAAGCG
ATCCACCGGCGAGAGGAGTTTGACCTGGATGTGGTTGCTGTGGTGAACGACACAGTCGGA
ACTATGATGACCTGTGGCTTTGAAGACCCTCACTGTGAAGTTGGCCTCATTGTTGGCACG
GGCAGCAATGCCTGCTACATGGAGGAGATGCGCAACGTGGAACTGGTGGAAGGAGAAGAG
GGGCGGATGTGTGTGAACATGGAATGGGGGGCCTTCGGGGACAATGGATGCCTAGATGAC
TTCCGCACAGAATTTGATGTGGCTGTGGATGAGCTTTCACTCAACCCCGGCAAGCAGAGG
TTCGAGAAAATGATCAGTGGAATGTACCTGGGTGAGATTGTCCGTAACATTCTCATCGAT
TTCACCAAGCGTGGACTACTCTTCCGAGGCCGCATCTCAGAGCGGCTCAAGACAAGGGGC
ATCTTTGAAACCAAGTTCTTGTCTCAGATTGAGAGTGACTGCCTGGCCCTGCTGCAAGTC
CGAGCCACCCTGCAACACTTAGGGCTTGAGAGCACCTGTGACGACAGCATCATTGTTAAG
GAGGTGTGCACTGTGGTGGCCCGGCGGGCAGCCCAGCTCTGTGGCGCAGGCATGGCCGCT
GTGGTGGACAGGATACGAGAAAACCGTGGGCTGGACGCTCTCAAAGTGACAGTGGGTGTG
GATGGGACCCTCTACAAGCTACATCCTCACTTTGCCAAAGTCATGCATGAGACAGTGAAG
GACCTGGCTCCGAAATGTGATGTGTCTTTCCTGCAGTCAGAGGATGGCAGCGGGAAGGGG
GCGGCGCTCATCACTGCTGTGGCCTGCCGCATCCGTGAGGCTGGACAGCGATAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
Z46376

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_9_Locus:
2p13

# Metabolic_Enzyme_9_SNPs:
rs2229629; rs3732299; rs28363029; rs28363015; rs2306808; rs2229626; rs10194657; rs2229622; rs28363033; rs28363014; rs943; rs656489; rs9679561; rs3832165; rs3732298; rs3732295; rs3821305; rs3732296; rs28363066; rs1061314; rs28384370; rs28362959; rs28363067; rs28384369; rs651071; rs2279429; rs1545522; rs681900; rs923273; rs1545523; rs1872837; rs3771755; rs4853066; rs1565064; rs3771782; rs3771772; rs3821307; rs11893422; rs680545; rs6732614; rs3771754; rs678350; rs11903758; rs11694331; rs694644; rs6754642; rs1032206; rs1869339; rs3771798; rs11688312; rs3771770; rs2171385; rs1487371; rs13395967; rs685363; rs6735303; rs3771781; rs4853069; rs3771752; rs6730141; rs2306806; rs3771756; rs4241264; rs10153633; rs3771771; rs3771763; rs3816456; rs17010492; rs11688305; rs13384240; rs3755454; rs3821310; rs11675401; rs2279428; rs6749471; rs10496195; rs28363012; rs3771751; rs3732300; rs28362967; rs4852347; rs3771786; rs3771759; rs3755453; rs6722578; rs4853067; rs28362977; rs3771768; rs3771773; rs28362973; rs3771783; rs3771760; rs3821309; rs1869340; rs4853064; rs3771758; rs3771769; rs11888976; rs3755452; rs2068358; rs10153634; rs17741356; rs3732301; rs4853068; rs3771753; rs6752205; rs11675438; rs4853065; rs6720940; rs2306805; rs3771790; rs3771766; rs17010467; rs28363062; rs13382443; rs3771761; rs28362980; rs28362969; rs3771775; rs10183051; rs3821311; rs3771762; rs604207; rs2123615; rs28362972; rs3755450; rs1807090; rs7602790; rs602898; rs634849; rs28363004; rs3771792; rs13394603; rs17010460; rs675611; rs28363048; rs28746193; rs28363047; rs28362983; rs28363042; rs28363035; rs28363055; rs28362999; rs28363003; rs3771788; rs28363044; rs3771793; rs5832141; rs28363060; rs28362996; rs3821308; rs11680091; rs2901626; rs3771778; rs11126442; rs28363053; rs28363021; rs17010436; rs28363011; rs11675530; rs28363054; rs28362979; rs28363008; rs28362968; rs6709975; rs28362997; rs13389855; rs28363032; rs2422043; rs17010464; rs842667; rs28363028; rs28362993; rs3078015; rs28362965; rs3755451; rs28363040; rs28362981; rs604112; rs3771784; rs28362964; rs13405909; rs663504; rs28363037; rs1565063; rs603743; rs6756096; rs13398307; rs28363027; rs28363049; rs13397480; rs11894886; rs17010504; rs28363031; rs28362987; rs28362990; rs4852348; rs28363023; rs3771767; rs2279427; rs3771785; rs28746191; rs680015; rs35902493; rs28362986; rs3771791; rs28363000; rs28363041; rs17847166; rs1386536; rs3821306; rs7572459; rs10496196; rs10496197; rs28363016; rs28363065; rs17847161; rs35677390; rs36066402; rs28363057; rs35396457; rs28363006; rs17847160; rs28363005; rs28363051; rs11556194; rs3202369; rs3732302; rs13429546; rs34573284; rs3832164; rs28384371; rs28362960; rs6741953; rs11556193; rs28384372; rs28384368; rs10451660; rs28362991; rs6755864; rs28363026; rs28363056; rs34315149; rs35716613; rs11689606; rs28363061; rs2029236; rs28362988; rs28363050; rs28363043; rs684491; rs28363034; rs2901627; rs11295383; rs5832143; rs618023; rs28362963; rs28362995; rs28363059; rs35137588; rs34780455; rs13432314; rs28363022; rs11450211; rs34286902; rs35601612; rs2422045; rs28362971; rs3771776; rs13395815; rs34063910; rs636903; rs28362978; rs6707123; rs5832142; rs6743207; rs35570397; rs13386610; rs676065; rs28362992; rs28363007; rs34662031; rs3836190; rs17847145; rs28362962; rs28363058; rs28363039; rs35888944; rs13387771; rs13004379; rs28362974; rs28362984; rs3836189; rs28362989; rs600578; rs35586432; rs28363064; rs10675736; rs6708938; rs17847149; rs35315423; rs10175889; rs28363019; rs3077985; rs35276905; rs28363036; rs35227945; rs3771787; rs35771648; rs7604247; rs2422046; rs3771774; rs11459447; rs28567425; rs35641789; rs11369279; rs6753090; rs28362961; rs11688513; rs11300678; rs28363018; rs10169547; rs28363024; rs34066885; rs6728248; rs7596751; rs28363010; rs28363002; rs36226712; rs28363052; rs34552028; rs2901628; rs28362976; rs3836188; rs28363046; rs7557784; rs17847165; rs35591732; rs28363063; rs28363020; rs28363025; rs28362985; rs28363009; rs34553329; rs35969102; rs28746192; rs7596131; rs10688878; rs35605685; rs2422044; rs34611487; rs28363017; rs3836187; rs28362982; rs17847158; rs36027258; rs5832144; rs28363001; rs34885061; rs41498345; rs28362994; rs34743801; rs34980367; rs636472; rs34106533; rs28969559; rs11308687; rs28363013; rs28363045; rs28363038; rs28362966; rs34842573; rs13020188; rs28362970; rs3771779; rs35454195; rs3771780; rs28746194; rs3771796; rs7600390; rs34021969; rs13411123; rs28362975; rs28362998; rs28363030; rs13013519; rs10865403; rs28384373; rs7424799; rs35575305; rs608112; rs659635; rs619850; rs3887287; rs35614058; rs35250889; rs10865404; rs11892954; rs12151815; rs1565068; rs17678046; rs17678088; rs2087173; rs2129603; rs34610149; rs4241265; rs4443023; rs4443024; rs4549114; rs4853059; rs5020284; rs628983; rs6546935; rs657209; rs670083; rs6730659; rs6758134; rs748357; rs7571422; rs7596427; rs7597871

# Metabolic_Enzyme_9_General_References:
8786021; 8250948; 7518342; 7883120; 7883122; 7883123

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
6080

# Metabolic_Enzyme_10_Name:
Transketolase-like protein 1

# Metabolic_Enzyme_10_Synonyms:
Transketolase 2; TK 2; Transketolase-related protein

# Metabolic_Enzyme_10_Gene_Name:
TKTL1

# Metabolic_Enzyme_10_Protein_Sequence:
>Transketolaselike protein 1
MADAEARAEFPEEARPDRGTLQVLQDMASRLRIHSIRATCSTSSGHPTSCSSSSEIMSVL
FFYIMRYKQSDPENPDNDRFVLAKRLSFVDVATGWLGQGLGVACGMAYTGKYFDRASYRV
FCLMSDGESSEGSVWEAMAFASYYSLDNLVAIFDVNRLGHSGALPAEHCINIYQRRCEAF
GWNTYVVDGRDVEALCQVFWQASQVKHKPTAVVAKTFKGRGTPSIEDAESWHAKPMPRER
ADAIIKLIESQIQTSRNLDPQPPIEDSPEVNITDVRMTSPPDYRVGDKIATRKACGLALA
KLGYANNRVVVLDGDTRYSTFSEIFNKEYPERFIECFMAEQNMVSVALGCASRGRTIAFA
STFAAFLTRAFDHIRIGGLAESNINIIGSHCGVSVGDDGASQMALEDIAMFRTIPKCTIF
YPTDAVSTEHAVALAANAKGMCFIRTTRPETMVIYTPQERFEIGQAKVLRHCVSDKVTVI
GAGITVYEALAAADELSKQDIFIRVIDLFTIKPLDVATIVSSAKATEGRIITVEDHYPQG
GIGEAVCAAVSMDPDIQVHSLAVSGVPQSGKSEELLDMYGISARHIIVAVKCMLLN

# Metabolic_Enzyme_10_Number_of_Residues:
596

# Metabolic_Enzyme_10_Molecular_Weight:
65334

# Metabolic_Enzyme_10_Theoretical_pI:
5.65

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring aldehyde or ketonic groups
Function:  transketolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_10_Specific_Function:
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

# Metabolic_Enzyme_10_Pathway:
map00030  Pentose phosphate pathway;
 map00710  Carbon fixation;
 map01051  Biosynthesis of ansamycins

# Metabolic_Enzyme_10_Reaction:
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF02779:Transket_pyr;
PF02780:Transketolase_C;
PF00456:Transketolase_N

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.2.1.1

# Metabolic_Enzyme_10_GenBank_ID_Protein:
1232175

# Metabolic_Enzyme_10_SwissProt_ID:
TKTL1_HUMAN (P51854)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
TKTL1

# Metabolic_Enzyme_10_Geneatlas_id:
TKTL1

# Metabolic_Enzyme_10_hgnc_id:
HGNC:11835

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic and to a lesser extent also nuclear

# Metabolic_Enzyme_10_Gene_Sequence:
>1623 bp
ATGTCTGTGCTGTTCTTCTACATCATGAGGTACAAGCAGTCAGATCCAGAGAATCCGGAC
AACGACCGATTTGTCCTCGCAAAGAGACTGTCGTTTGTGGATGTGGCAACAGGATGGCTC
GGACAAGGACTGGGAGTTGCATGTGGAATGGCATATACTGGCAAGTACTTCGACAGGGCC
AGCTACCGGGTGTTCTGCCTCATGAGTGATGGCGAGTCCTCAGAAGGCTCTGTCTGGGAG
GCAATGGCCTTTGCTTCCTACTACAGTCTGGACAATCTTGTGGCAATCTTTGATGTGAAC
CGCCTGGGACACAGTGGTGCATTGCCCGCCGAGCACTGCATAAACATCTATCAGAGGCGC
TGCGAAGCCTTTGGGTGGAACACTTATGTGGTGGACGGCCGGGACGTGGAGGCACTGTGC
CAGGTATTCTGGCAGGCTTCTCAGGTGAAGCACAAGCCCACTGCTGTGGTGGCCAAGACC
TTCAAGGGCCGGGGCACCCCAAGTATTGAGGATGCAGAAAGTTGGCATGCAAAGCCAATG
CCGAGAGAAAGAGCAGATGCCATTATCAAATTAATTGAGAGCCAGATACAGACCAGCAGG
AATCTTGACCCACAGCCCCCCATTGAGGACTCACCTGAAGTCAACATCACAGATGTAAGG
ATGACCTCTCCACCTGATTACAGAGTTGGTGACAAGATAGCTACTCGGAAAGCATGCGGT
CTGGCTCTGGCTAAGCTGGGCTACGCGAACAACAGAGTCGTTGTGCTGGATGGTGACACC
AGGTACTCTACTTTCTCTGAGATATTCAACAAGGAGTACCCTGAGCGCTTCATCGAGTGC
TTTATGGCTGAACAAAACATGGTGAGCGTGGCTCTGGGCTGTGCCTCCCGTGGACGGACC
ATTGCTTTTGCTAGCACCTTTGCTGCCTTTCTGACTCGAGCATTTGATCACATCCGGATA
GGAGGCCTCGCTGAGAGCAACATCAACATTATTGGTTCCCACTGTGGGGTATCTGTTGGT
GACGATGGTGCTTCCCAGATGGCCCTGGAGGATATAGCCATGTTCCGAACCATTCCCAAG
TGCACGATCTTCTACCCAACTGATGCCGTCTCCACGGAGCATGCTGTTGCTCTGGCAGCC
AATGCCAAGGGGATGTGCTTCATTCGGACCACCCGACCAGAAACTATGGTTATTTACACC
CCACAAGAACGCTTTGAGATCGGACAGGCCAAGGTCCTCCGCCACTGTGTCAGTGACAAG
GTCACAGTTATTGGAGCTGGAATTACTGTGTATGAAGCCTTAGCAGCTGCTGATGAGCTT
TCGAAACAAGATATTTTTATCCGTGTCATCGACCTGTTTACCATTAAACCTCTGGATGTC
GCCACCATCGTCTCCAGTGCAAAAGCCACAGAGGGCCGGATCATTACAGTGGAGGATCAC
TACCCGCAAGGTGGCATCGGGGAAGCTGTCTGCGCAGCCGTCTCCATGGATCCTGACATT
CAGGTTCATTCGCTGGCAGTGTCGGGAGTGCCCCAGAGTGGGAAGTCCGAGGAATTGCTG
GATATGTATGGAATTAGTGCCAGACATATCATAGTGGCCGTGAAATGCATGTTGCTGAAC
TAA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
X91817

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_10_Locus:
Xq28

# Metabolic_Enzyme_10_SNPs:
rs17174296; rs2872817; rs12010971; rs12014497; rs17336725; rs17091217; rs766419; rs2239467; rs5987244; rs5987245; rs5987246; rs2315056; rs766420; rs5987242; rs17336718; rs2239466; rs7882247; rs5986968; rs2266894; rs2283761; rs5987237; rs2239468; rs4898475; rs12559330; rs10126322; rs12012047; rs5987241; rs4898474; rs5986969; rs6655282; rs5987239; rs12558211; rs11796895; rs6643842; rs17281251; rs12556555; rs17852259; rs34204897; rs11541774; rs12687689; rs2283759; rs12384846; rs11796894; rs35220504; rs11390439; rs12834363; rs12861292; rs11388137; rs4272554; rs5904383; rs6643844; rs34305192; rs12858825; rs7059658; rs766418; rs7054539; rs11444073; rs12832683; rs4898378; rs12848002; rs5986970; rs5987243; rs6571309; rs7878511; rs2266893; rs33991397; rs12688821; rs6655280; rs5987240; rs35018687; rs34229834; rs10602804; rs6655279; rs34910176; rs34278084; rs2283760; rs5987238; rs5945410; rs6655281; rs3056971; rs12390625; rs17091374; rs17091376; rs17091380; rs5945412; rs5945413; rs6643845; rs6655283

# Metabolic_Enzyme_10_General_References:
8838793

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5447

# Metabolic_Enzyme_11_Name:
Hexokinase-1

# Metabolic_Enzyme_11_Synonyms:
Hexokinase type I; HK I; Brain form hexokinase

# Metabolic_Enzyme_11_Gene_Name:
HK1

# Metabolic_Enzyme_11_Protein_Sequence:
>Hexokinase1
MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT
VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH
GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV
EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME
ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM
YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG
VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH
PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT
KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV
LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF
TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG
TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD
IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG
IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA
VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG
AALITAVGVRLRTEASS

# Metabolic_Enzyme_11_Number_of_Residues:
917

# Metabolic_Enzyme_11_Molecular_Weight:
102487

# Metabolic_Enzyme_11_Theoretical_pI:
6.78

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Not Available

# Metabolic_Enzyme_11_Specific_Function:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_11_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism;
 map00521  Streptomycin biosynthesis;
 map00530  Aminosugars metabolism

# Metabolic_Enzyme_11_Reaction:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00349:Hexokinase_1;
PF03727:Hexokinase_2

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.7.1.1

# Metabolic_Enzyme_11_GenBank_ID_Protein:
184021

# Metabolic_Enzyme_11_SwissProt_ID:
HXK1_HUMAN (P19367)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
HK1

# Metabolic_Enzyme_11_Geneatlas_id:
HK1

# Metabolic_Enzyme_11_hgnc_id:
HGNC:4922

# Metabolic_Enzyme_11_PDB_ID:
1HKB

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding

# Metabolic_Enzyme_11_Gene_Sequence:
>2754 bp
ATGATCGCCGCGCAGCTCCTGGCCTATTACTTCACGGAGCTGAAGGATGACCAGGTCAAA
AAGATTGACAAGTATCTGTATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATG
ACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTAATCCAACAGCCACA
GTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGAAAAGGGAGATTTC
ATTGCCCTGGATCTTGGTGGGTCTTCCTTTCGAATTCTGCGGGTGCAAGTGAATCATGAG
AAAAACCAGAATGTTCACATGGAGTCCGAGGTTTATGACACCCCAGAGAACATCGTGCAC
GGCAGTGGAAGCCAGCTTTTTGATCATGTTGCTGAGTGCCTGGGAGATTTCATGGAGAAA
AGGAAGATCAAGGACAAGAAGTTACCTGTGGGATTCACGTTTTCTTTTCCTTGCCAACAA
TCCAAAATAGATGAGGCCATCCTGATCACCTGGACAAAGCGATTTAAAGCGAGCGGAGTG
GAAGGAGCAGATGTGGTCAAACTGCTTAACAAAGCCATCAAAAAGCGAGGGGACTATGAT
GCCAACATCGTAGCTGTGGTGAATGACACAGTGGGCACCATGATGACCTGTGGCTATGAC
GACCAGCACTGTGAAGTCGGCCTGATCATCGGCACTGGCACCAATGCTTGCTACATGGAG
GAACTGAGGCACATTGATCTGGTGGAAGGAGACGAGGGGAGGATGTGTATCAATACAGAA
TGGGGAGCCTTTGGAGACGATGGATCATTAGAAGACATCCGGACAGAGTTTGACAGGGAG
ATAGACCGGGGATCCCTCAACCCTGGAAAACAGCTGTTTGAGAAGATGGTCAGTGGCATG
TACTTGGGAGAGCTGGTTCGACTGATCCTAGTCAAGATGGCCAAGGAGGGCCTCTTATTT
GAAGGGCGGATCACCCCGGAGCTGCTCACCCGAGGGAAGTTTAACACCAGTGATGTGTCA
GCCATCGAAAAGAATAAGGAAGGCCTCCACAATGCCAAAGAAATCCTGACCCGCCTGGGA
GTGGAGCCGTCCGATGATGACTGTGTCTCAGTCCAGCACGTTTGCACCATTGTCTCATTT
CGCTCAGCCAACTTGGTGGCTGCCACACTGGGCGCCATCTTGAACCGCCTGCGTGATAAC
AAGGGCACACCCAGGCTGCGGACCACGGTTGGTGTCGACGGATCTCTTTACAAGACGCAC
CCACAGTATTCCCGGCGTTTCCACAAGACTCTAAGGCGCTTGGTGCCAGACTCCGATGTG
CGCTTCCTCCTCTCGGAGAGTGGCAGCGGCAAGGGGGCTGCCATGGTGACGGCGGTGGCC
TACCGCTTGGCCGAGCAGCACCGGCAGATAGAGGAGACCCTGGCTCATTTCCACCTCACC
AAAGACATGCTGCTGGAGGTGAAGAAGAGGATGCGGGCCGAGATGGAGCTGGGGCTGAGG
AAGCAGACGCACAACAATGCCGTGGTTAAGATGCTGCCCTCCTTCGTCCGGAGAACTCCC
GACGGGACCGAGAATGGTGACTTCTTGGCCCTGGATCTTGGAGGAACCAATTTCCGTGTG
CTGCTGGTGAAAATCCGTAGTGGGAAAAAGAGAACGGTGGAAATGCACAACAAGATCTAC
GCCATTCCTATTGAAATCATGCAGGGCACTGGGGAAGAGCTGTTTGATCACATTGTCTCC
TGCATCTCTGACTTCTTGGACTACATGGGGATCAAAGGCCCCAGGATGCCTCTGGGCTTC
ACGTTCTCATTTCCCTGCCAGCAGACGAGTCTGGACGCGGGAATCTTGATCACGTGGACA
AAGGGTTTTAAGGCAACAGACTGCGTGGGCCACGATGTAGTCACCTTACTAAGGGATGCG
ATAAAAAGGAGAGAGGAATTTGACCTGGACGTGGTGGCTGTGGTCAACGACACAGTGGGC
ACCATGATGACCTGTGCTTATGAGGAGCCCACCTGTGAGGTTGGACTCATTGTTGGGACC
GGCAGCAATGCCTGCTACATGGAGGAGATGAAGAACGTGGAGATGGTGGAGGGGGACCAG
GGGCAGATGTGCATCAACATGGAGTGGGGGGCCTTTGGGGACAACGGGTGTCTGGATGAT
ATCAGGACACACTACGACAGACTGGTGAACGAATATTCCCTAAATGCTGGGAAACAAAGG
TATGAGAAGATGATCAGTGGTATGTACCTGGGTGAAATCGTCCGCAACATCTTAATCGAC
TTCACCAAGAAGGGATTCCTCTTCCGAGGGCAGATCTCTGAGACGATGAAGACCCGGGGC
ATCTTTGAGACCAAGTTTCTCTCTCAGATCGAGAGTGACCGATTAGCACTGCTCCAGGTC
CGGGCTATCCTCCAGCAGCTAGGTCTGAATAGCACCTGCGATGACAGTATCCTCGTCAAG
ACAGTGTGCGGGGTGGTGTCCAGGAGGGCCGCACAGCTGTGTGGCGCAGGCATGGCTGCG
GTTGTGGATAAGATCCGCGAGAACAGAGGACTGGACCGTCTGAATGTGACTGTGGGAGTG
GACGGGACACTCTACAAGCTTCATCCACACTTCTCCAGAATCATGCACCAGACGGTGAAG
GAACTGTCACCAAAATGTAACGTGTCCTTCCTCCTGTCTGAGGATGGCAGCGGCAAGGGG
GCCGCCCTCATCACGGCCGTGGGCGTGCGGTTACGCACAGAGGCAAGCAGCTAA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
M75126

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_11_Locus:
10q22

# Metabolic_Enzyme_11_SNPs:
rs906220; rs1054203; rs748235; rs12254258; rs1133189; rs10998760; rs34616021; rs14006; rs2394539; rs10998704; rs6480394; rs10762281; rs3812689; rs10998703; rs4746834; rs7893994; rs4469773; rs7914134; rs1472817; rs2894081; rs11815833; rs2394540; rs10823332; rs10762280; rs10762277; rs2394543; rs7897621; rs4746837; rs7068435; rs13139; rs1876257; rs5030916; rs10998700; rs11819086; rs12257270; rs2394545; rs11818777; rs10998699; rs10762275; rs7907176; rs7903625; rs12216; rs10998702; rs1472819; rs2394541; rs7095428; rs1472816; rs2394538; rs10823333; rs10998692; rs11813648; rs11818779; rs10762276; rs10823329; rs12242964; rs12242332; rs10762273; rs1472818; rs11818927; rs10998684; rs2394535; rs11815263; rs7095547; rs10823328; rs10823335; rs12751; rs10823331; rs10998694; rs11815943; rs11815513; rs4746833; rs12244771; rs10762278; rs10823334; rs2894080; rs11818799; rs5030886; rs2394537; rs2089356; rs10998696; rs10998689; rs11819674; rs10762279; rs7092374; rs10823330; rs2002905; rs12263326; rs4372334; rs10998691; rs11816714; rs12265826; rs4746836; rs10740318; rs7095424; rs12218331; rs7907242; rs5030949; rs11816128; rs7095579; rs12241382; rs1867972; rs2084274; rs1867971; rs906215; rs1867975; rs749108; rs2305198; rs4537657; rs7084213; rs11596193; rs7909192; rs2305196; rs1227938; rs7072268; rs10823348; rs10159541; rs7094651; rs7084363; rs1900466; rs12414591; rs10762288; rs10733851; rs7921170; rs7921060; rs7095140; rs749107; rs10762282; rs2015803; rs6480396; rs6480404; rs1867973; rs3812691; rs10998738; rs11595647; rs11812791; rs10823360; rs9664217; rs4745988; rs10823350; rs10159477; rs10823357; rs12243794; rs4746848; rs10998730; rs7097078; rs749105; rs7071731; rs4745987; rs16926253; rs7076563; rs3793846; rs10998725; rs2305197; rs4072508; rs7898060; rs11597346; rs6480400; rs11596110; rs7092155; rs2394560; rs4745981; rs4589168; rs11595655; rs10823343; rs3829185; rs11599680; rs10823354; rs6480403; rs12262904; rs10998751; rs4746838; rs10823349; rs11819564; rs10762292; rs1867974; rs906216; rs2278745; rs10998754; rs10823356; rs10159540; rs11818709; rs4746839; rs7079157; rs7088667; rs7094214; rs11599150; rs4746846; rs11598389; rs1900467; rs10823345; rs12265560; rs10762290; rs2394561; rs10823355; rs10823340; rs12244847; rs2305199; rs4746841; rs749106; rs7913579; rs7076745; rs3793845; rs10823341; rs11596587; rs11596868; rs10998720; rs7905437; rs7917338; rs6480402; rs7914033; rs16926244; rs3829183; rs7067927; rs7912524; rs12416320; rs16926252; rs12571072; rs4746849; rs11596199; rs10823339; rs10998728; rs6480398; rs10823342; rs11813750; rs12415409; rs10998739; rs10762284; rs10998742; rs10823353; rs10998741; rs10128334; rs7895704; rs7902303; rs4745982; rs11818471; rs10159490; rs4746847; rs10128330; rs10762285; rs5030915; rs10998719; rs12252483; rs7072349; rs6480399; rs4745986; rs10998752; rs10998710; rs7905515; rs3793847; rs7904932; rs17489768; rs12255367; rs10998747; rs34895304; rs12240847; rs10823358; rs17567544; rs906221; rs12251732; rs10823338; rs10823351; rs9299503; rs10998726; rs10998735; rs12253797; rs10998706; rs7067730; rs12248026; rs12243312; rs12262357; rs4471325; rs11599654; rs12252916; rs3793844; rs7081302; rs10998715; rs12262687; rs16926246; rs7905243; rs10823352; rs10823337; rs10762286; rs10823359; rs10128513; rs10998748; rs17476364; rs10159599; rs11597225; rs10823344; rs10998736; rs7902486; rs12220752; rs7094943; rs7920991; rs10998731; rs16926242; rs10998723; rs12254195; rs10762293; rs4746851; rs7899625; rs16926292; rs10159598; rs2135589; rs10823347; rs4364944; rs7077298; rs10998716; rs16926249; rs11599655; rs12243716; rs7097551; rs10998744; rs10762283; rs12771121; rs7083032; rs12411628; rs10762287; rs10762291; rs7913272; rs12355201; rs5030917; rs10998733; rs10998740; rs1108272; rs4746850; rs11819352; rs10823346; rs12778692; rs6480397; rs11593167; rs11816511; rs11812380; rs10998724; rs2394534; rs1054202; rs34410083; rs35378602; rs41279658; rs12356717; rs35387972; rs12243655; rs35468118; rs1803712; rs10998693; rs35379025; rs5785909; rs35517819; rs35080013; rs34434447; rs10998687; rs28558590; rs12357729; rs12219469; rs12780875; rs34997376; rs35104096; rs12780655; rs10762274; rs34150929; rs12263929; rs10998698; rs10998690; rs10716029; rs2394542; rs12221426; rs4282890; rs12569892; rs7916281; rs35143457; rs2394536; rs36020756; rs3086615; rs7083056; rs10998695; rs1810023; rs2063048; rs36007468; rs10998688; rs11286202; rs35585147; rs28422950; rs35431404; rs12242466; rs35264480; rs35699014; rs14382; rs34382339; rs34539856; rs5785910; rs4745980; rs4638197; rs5785908; rs34031234; rs12262447; rs11815616; rs34736420; rs10672043; rs35376303; rs34164890; rs12253706; rs7914285; rs4622145; rs34547808; rs11556966; rs34453032; rs10998685; rs12241639; rs10998686; rs10998701; rs10998697; rs10400052; rs12268098; rs11819094; rs35607669; rs7905200; rs2394544; rs3750793; rs35895463; rs7083200; rs12220458; rs7914344; rs12259682; rs12571243; rs7894213; rs34610927; rs12253579; rs35804876; rs41279664; rs5030950; rs34938278; rs12242474; rs34931035; rs12780492; rs35306200; rs34327925; rs1057566; rs11819447; rs10668853; rs4453112; rs41279662; rs12252651; rs10998745; rs36104030; rs12247331; rs33984080; rs4366384; rs35347843; rs35619781; rs11592707; rs34834335; rs891564; rs34694521; rs35135619; rs5785912; rs34040090; rs35627580; rs10578071; rs6143971; rs1867970; rs12780794; rs10998734; rs11816980; rs35368978; rs10998714; rs11597178; rs34605664; rs10998756; rs7478446; rs34064357; rs11497990; rs10688656; rs7911813; rs7476246; rs12254694; rs34142395; rs35932296; rs1867976; rs12252489; rs35684348; rs35802626; rs36006142; rs35233497; rs10998757; rs16926233; rs10998709; rs10998722; rs12240898; rs34164799; rs34068824; rs41435648; rs35975244; rs34124986; rs35131910; rs11819725; rs11424399; rs906223; rs7476298; rs35300718; rs10998729; rs36006221; rs5785913; rs11597418; rs34156889; rs11592659; rs10679551; rs10159538; rs10998755; rs35790367; rs36124339; rs5030919; rs16926269; rs41279656; rs12264809; rs35680310; rs11596222; rs34391428; rs36012744; rs34821837; rs10580275; rs10998718; rs12769898; rs7090983; rs34729523; rs35983460; rs11598601; rs34428846; rs11597672; rs35532806; rs10998708; rs35337416; rs2089357; rs3086649; rs10998746; rs10684489; rs5019350; rs12248865; rs35385375; rs35827992; rs11400433; rs10128509; rs35246952; rs35351562; rs33920450; rs10998707; rs35258842; rs10998737; rs16926245; rs34348007; rs12765788; rs12248628; rs7911786; rs10998743; rs17489948; rs34969484; rs6480401; rs12258259; rs34967951; rs11591962; rs41279660; rs35833065; rs10998759; rs3086686; rs12782422; rs10998711; rs35024696; rs34137364; rs33920304; rs35326884; rs34301815; rs35860582; rs906222; rs35929312; rs7093863; rs11389885; rs10998705; rs3812690; rs7081298; rs2894082; rs12360012; rs34309168; rs12769387; rs41279654; rs36096331; rs34767311; rs36022169; rs12247649; rs10542467; rs12770156; rs12259309; rs12245854; rs35510140; rs10998750; rs12357558; rs34815317; rs35215102; rs3956966; rs35733293; rs12765993; rs4745983; rs11295023; rs5019351; rs10998753; rs10998727; rs12769386; rs11421011; rs12243746; rs34133918; rs12356440; rs34966318; rs35451830; rs7094375; rs12359036; rs12763363; rs34977762; rs10047284; rs10998758; rs12098572; rs35694546; rs10603617; rs10531274; rs35035641; rs10998717; rs11593738; rs12257925; rs5030918; rs34367822; rs35534322; rs4745984; rs7072757; rs12243670; rs7088597; rs11267589; rs12411524; rs35376932; rs34620768; rs10823336; rs11597926; rs10998712; rs28510843; rs10536437; rs35922004; rs12263320; rs35828572; rs12246003; rs7094252; rs6480405; rs10998749; rs10159790; rs35341389; rs10998713; rs12264596; rs2278744; rs34085490; rs4746840; rs34767665; rs10998732; rs35490740; rs35026222; rs34941976; rs34818501; rs12264010; rs34125846; rs10998682; rs34564828; rs34015903; rs34747241; rs1000251; rs10740320; rs10998677; rs10998679; rs10998762; rs11813340; rs11815413; rs11817458; rs12244723; rs1227958; rs12776509; rs12781552; rs1549797; rs1549798; rs1549799; rs16926201; rs2278746; rs2611; rs34690134; rs35008643; rs3740601; rs3793849; rs3793850; rs3793851; rs4603200; rs4644560; rs4746832; rs6480393; rs7097827; rs7097971; rs7098065; rs906219; rs986525

# Metabolic_Enzyme_11_General_References:
3207429; 9531504; 1637300; 1985912; 9028305; 10978502; 8706938; 9493266; 9735292; 10574795; 10686099; 7655856

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5442

# Metabolic_Enzyme_12_Name:
Glucokinase

# Metabolic_Enzyme_12_Synonyms:
Hexokinase-4; Hexokinase type IV; HK IV; HK4; Hexokinase-D

# Metabolic_Enzyme_12_Gene_Name:
GCK

# Metabolic_Enzyme_12_Protein_Sequence:
>Glucokinase
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ

# Metabolic_Enzyme_12_Number_of_Residues:
465

# Metabolic_Enzyme_12_Molecular_Weight:
52192

# Metabolic_Enzyme_12_Theoretical_pI:
4.85

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Not Available

# Metabolic_Enzyme_12_Specific_Function:
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage

# Metabolic_Enzyme_12_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism;
 map00521  Streptomycin biosynthesis

# Metabolic_Enzyme_12_Reaction:
ATP + D-glucose = ADP + D-glucose 6-phosphate

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00349:Hexokinase_1;
PF03727:Hexokinase_2

# Metabolic_Enzyme_12_Signals:
None

# Metabolic_Enzyme_12_Transmembrane_Regions:
None

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 2.7.1.2

# Metabolic_Enzyme_12_GenBank_ID_Protein:
179427

# Metabolic_Enzyme_12_SwissProt_ID:
HXK4_HUMAN (P35557)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
GCK

# Metabolic_Enzyme_12_Geneatlas_id:
GCK

# Metabolic_Enzyme_12_hgnc_id:
HGNC:4195

# Metabolic_Enzyme_12_PDB_ID:
1V4T

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Not Available

# Metabolic_Enzyme_12_Gene_Sequence:
>1398 bp
ATGCTGGACGACAGAGCCAGGATGGAGGCCGCCAAGAAGGAGAAGGTAGAGCAGATCCTG
GCAGAGTTCCAGCTGCAGGAGGAGGACCTGAAGAAGGTGATGAGACGGATGCAGAAGGAG
ATGGACCGCGGCCTGAGGCTGGAGACCCATGAAGAGGCCAGTGTGAAGATGCTGCCCACC
TACGTGCGCTCCACCCCAGAAGGCTCAGAAGTCGGGGACTTCCTCTCCCTGGACCTGGGT
GGCACTAACTTCAGGGTGATGCTGGTGAAGGTGGGAGAAGGTGAGGAGGGGCAGTGGAGC
GTGAAGACCAAACACCAGATGTACTCCATCCCCGAGGACGCCATGACCGGCACTGCTGAG
ATGCTCTTCGACTACATCTCTGAGTGCATCTCCGACTTCCTGGACAAGCATCAGATGAAA
CACAAGAAGCTGCCCCTGGGCTTCACCTTCTCCTTTCCTGTGAGGCACGAAGACATCGAT
AAGGGCATCCTTCTCAACTGGACCAAGGGCTTCAAGGCCTCAGGAGCAGAAGGGAACAAT
GTCGTGGGGCTTCTGCGAGACGCTATCAAACGGAGAGGGGACTTTGAAATGGATGTGGTG
GCAATGGTGAATGACACGGTGGCCACGATGATCTCCTGCTACTACGAAGACCATCAGTGC
GAGGTCGGCATGATCGTGGGCACGGGCTGCAATGCCTGCTACATGGAGGAGATGCAGAAT
GTGGAGCTGGTGGAGGGGGACGAGGGCCGCATGTGCGTCAATACCGAGTGGGGCGCCTTC
GGGGACTCCGGCGAGCTGGACGAGTTCCTGCTGGAGTATGACCGCCTGGTGGACGAGAGC
TCTGCAAACCCCGGTCAGCAGCTGTATGAGAAGCTCATAGGTGGCAAGTACATGGGCGAG
CTGGTGCGGCTTGTGCTGCTCAGGCTCGTGGACGAAAACCTGCTCTTCCACGGGGAGGCC
TCCGAGCAGCTGCGCACACGCGGAGCCTTCGAGACGCGCTTCGTGTCGCAGGTGGAGAGC
GACACGGGCGACCGCAAGCAGATCTACAACATCCTGAGCACGCTGGGGCTGCGACCCTCG
ACCACCGACTGCGACATCGTGCGCCGCGCCTGCGAGAGCGTGTCTACGCGCGCTGCGCAC
ATGTGCTCGGCGGGGCTGGCGGGCGTCATCAACCGCATGCGCGAGAGCCGCAGCGAGGAC
GTAATGCGCATCACTGTGGGCGTGGATGGCTCCGTGTACAAGCTGCACCCCAGCTTCAAG
GAGCGGTTCCATGCCAGCGTGCGCAGGCTGACGCCCAGCTGCGAGATCACCTTCATCGAG
TCGGAGGAGGGCAGTGGCCGGGGCGCGGCCCTGGTCTCGGCGGTGGCCTGTAAGAAGGCC
TGTATGCTGGGCCAGTGA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
M88011

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_12_Locus:
7p15.3-p15.1

# Metabolic_Enzyme_12_SNPs:
rs2908275; rs2908276; rs13306390; rs13306391; rs2284776; rs2268572; rs2908290; rs741038; rs758989; rs2908289; rs2070971; rs2908296; rs758985; rs2268576; rs2268574; rs2300586; rs1990458; rs2908297; rs1303722; rs3808319; rs2300584; rs2971672; rs2284777; rs12540369; rs2268575; rs2908298; rs2010825; rs12535229; rs7793213; rs2908292; rs2971677; rs3808323; rs12534623; rs2971679; rs2268570; rs2908274; rs730497; rs11766576; rs3808322; rs12673242; rs2971678; rs17832252; rs2268573; rs2971674; rs2971671; rs4724290; rs2041547; rs758987; rs13239289; rs2268569; rs3808320; rs17172566; rs10246064; rs758988; rs16881016; rs2300587; rs3808321; rs887688; rs2284773; rs758986; rs887686; rs2244164; rs10259649; rs12702069; rs2284769; rs6952751; rs11768239; rs2080033; rs2971676; rs887687; rs2971675; rs2908293; rs6945550; rs13306387; rs2908291; rs12702068; rs12534104; rs2215644; rs1799884; rs1476891; rs2908277; rs12702070; rs34389297; rs13306389; rs35548117; rs34322372; rs13306388; rs13306393; rs41282709; rs35140467; rs13306392; rs35521280; rs34255297; rs28639899; rs741039; rs5883891; rs2284771; rs34710012; rs34691097; rs2971670; rs34288160; rs34574619; rs34807880; rs3216596; rs34265547; rs34672149; rs34973571; rs35368425; rs13227198; rs36094778; rs35276355; rs28491181; rs34859037; rs34947625; rs5883890; rs35079658; rs34780996; rs35606092; rs34124036; rs2971680; rs3065183; rs41282712; rs35786405; rs4724291; rs3840676; rs34675661; rs2284778; rs11447509; rs2284779; rs2268577; rs10680351; rs1303721; rs2908294; rs34114506; rs1799831; rs36084943; rs2908295; rs11974018; rs34380942; rs36118223; rs35568119; rs2284772; rs34185745; rs11772934; rs35262363; rs11412934; rs35723429; rs2284774; rs41282715; rs36193808; rs11287012; rs6971410; rs41314139; rs2284775; rs35688609; rs13239987; rs34178750; rs28684786; rs35620913; rs35907141; rs34976798; rs34359315; rs3779606; rs13306394; rs3840677; rs1076439; rs36205687; rs35670475; rs11372006; rs36205684; rs2971681; rs36205686; rs36205690; rs36205688; rs1008384; rs12669054; rs17135975; rs17136076; rs17172591; rs17769733; rs2080032; rs2908278; rs2908286; rs2971669; rs3757838; rs3757840; rs4397301; rs4607517; rs6953355; rs6975024; rs735670; rs737525; rs741033; rs741034; rs741035; rs741036; rs741037; rs758983; rs882019; rs882020; rs882021

# Metabolic_Enzyme_12_General_References:
1354840; 1871135; 1511800; 1612194; 1502186; 1464666; 8194664; 1303265; 8454109; 8495817; 8325892; 8446612; 8168652; 9049484; 9662401; 9435328; 10588527; 11106831; 11372010

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
6081

# Metabolic_Enzyme_13_Name:
Fructose-1,6-bisphosphatase isozyme 2

# Metabolic_Enzyme_13_Synonyms:
D-fructose-1,6- bisphosphate 1-phosphohydrolase 2; FBPase 2

# Metabolic_Enzyme_13_Gene_Name:
FBP2

# Metabolic_Enzyme_13_Protein_Sequence:
>Fructose1,6bisphosphatase isozyme 2
MTDRSPFETDMLTLTRYVMEKGRQAKGTGELTQLLNSMLTAIKAISSAVRKAGLAHLYGI
AGSVNVTGDEVKKLDVLSNSLVINMVQSSYSTCVLVSEENKDAIITAKEKRGKYVVCFDP
LDGSSNIDCLASIGTIFAIYRKTSEDEPSEKDALQCGRNIVAAGYALYGSATLVALSTGQ
GVDLFMLDPALGEFVLVEKDVKIKKKGKIYSLNEGYAKYFDAATTEYVQKKKFPEDGSAP
YGARYVGSMVADVHRTLVYGGIFLYPANQKSPKGKLRLLYECNPVAYIIEQAGGLATTGT
QPVLDVKPEAIHQRVPLILGSPEDVQEYLTCVQKNQAGS

# Metabolic_Enzyme_13_Number_of_Residues:
339

# Metabolic_Enzyme_13_Molecular_Weight:
36744

# Metabolic_Enzyme_13_Theoretical_pI:
7.29

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_13_Specific_Function:
D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate

# Metabolic_Enzyme_13_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00030  Pentose phosphate pathway;
 map00051  Fructose and mannose metabolism;
 map00710  Carbon fixation

# Metabolic_Enzyme_13_Reaction:
D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF00316:FBPase

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
None

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 3.1.3.11

# Metabolic_Enzyme_13_GenBank_ID_Protein:
2154755

# Metabolic_Enzyme_13_SwissProt_ID:
F16P2_HUMAN (O00757)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
FBP2

# Metabolic_Enzyme_13_Geneatlas_id:
FBP2

# Metabolic_Enzyme_13_hgnc_id:
HGNC:3607

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_13_Gene_Sequence:
>1020 bp
ATGACGGACAGAAGCCCCTTCGAAACCGACATGCTCACCCTGACCCGCTACGTTATGGAA
AAGGGGCGTCAGGCCAAAGGGACTGGGGAGCTCACCCAGCTGCTGAACTCAATGCTGACG
GCCATCAAAGCCATCTCCTCGGCTGTGCGCAAGGCCGGTCTGGCCCACCTGTATGGAATC
GCAGGAAGCGTTAACGTGACGGGAGATGAGGTGAAGAAACTGGATGTGCTATCCAATTCC
CTGGTGATCAACATGCTCCAATCCTCCTATAGTACCTGCGTCCTGGTCTCAGAAGAGAAT
AAGGACGCCATCATCACCGCCAAGGAGAAGCGGGGGAAATACGTGGTCTGCTTTGACCCA
CTGGATGGATCTTCCAATATTGACTGCCTGGCCTCCATCGGAACCATCTTTGCCATCTAT
AGAAAGACCTCAGAGGATGAGCCTTCTGAAAAGGATGCCCTGCAGTGTGGCCGCAATATT
GTGGCCGCAGGTTATGCGCTGTACGGTAGTGCAACCCTGGTGGCTCTCTCCACAGGGCAA
GGCGTGGACCTCTTCATGCTTGACCCGGCTCTTGGTGAATTTGTCCTGGTGGAAAAAGAT
GTCAAGATTAAGAAGAAAGGAAAGATTTACAGCCTGAATGAGGGCTATGCCAAGTATTTT
GATGCGGCCACCACTGAATATGTGCAGAAAAAGAAATTCCCTGAGGATGGCAGTGCTCCC
TATGGGGCCAGGTATGTGGGCTCCATGGTGGCTGACGTGCACCGCACCCTGGTCTATGGA
GGAATCTTCCTGTACCCAGCCAACCAGAAGAGCCCTAAGGGCAAGCTCCGGCTCCTGTAT
GAATGCAATCCCGTGGCCTACATCATTGAGCAGGCAGGAGGCTTGGCGACCACGGGGACC
CAGCCTGTACTGGACGTGAAGCCCGAGGCAATTCACCAGCGAGTCCCCCTCATTCTGGGG
TCACCAGAGGATGTGCAGGAATATCTCACCTGTGTGCAGAAAAATCAGGCAGGCAGCTAG


# Metabolic_Enzyme_13_GenBank_ID_Gene:
Y10812

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_13_Locus:
9q22.3

# Metabolic_Enzyme_13_SNPs:
rs573212; rs2280301; rs1048510; rs1543185; rs2679602; rs540124; rs598386; rs509022; rs644237; rs802918; rs599229; rs609901; rs540236; rs635108; rs642477; rs965474; rs2987883; rs642952; rs2945796; rs2406665; rs693122; rs7039582; rs600130; rs3852401; rs2987882; rs6479554; rs7035381; rs7870433; rs1754432; rs645125; rs576745; rs612498; rs10115929; rs2406666; rs2945798; rs2280300; rs642035; rs10821367; rs498533; rs4744353; rs4744354; rs10116047; rs10821368; rs612952; rs7868159; rs564430; rs498635; rs2292900; rs2987900; rs501380; rs3864789; rs3864790; rs558753; rs548348; rs532027; rs4744357; rs2772011; rs10739976; rs2406664; rs693399; rs7865241; rs558990; rs10761339; rs1754433; rs688843; rs2280303; rs514222; rs781648; rs10761338; rs11790267; rs597003; rs7865772; rs2280302; rs660911; rs16910256; rs539320; rs632506; rs10761336; rs3824485; rs10115132; rs10993251; rs12684576; rs12684591; rs612115; rs10117289; rs2772012; rs586140; rs12683919; rs7861787; rs10993250; rs618272; rs10993248; rs478604; rs663385; rs10122208; rs7036264; rs11789810; rs12684837; rs4743959; rs12238316; rs2460138; rs10821369; rs558526; rs2679606; rs7851510; rs10114605; rs10117554; rs515339; rs3892541; rs802919; rs781650; rs2679601; rs478563; rs10761342; rs7862669; rs12115356; rs10821370; rs1568305; rs612202; rs2772023; rs10114599; rs612153; rs10761335; rs10993254; rs4314706; rs2993963; rs874248; rs2945802; rs2017136; rs7855117; rs2772013; rs10761344; rs10761334; rs10115489; rs35600708; rs41281156; rs41281154; rs41281152; rs10657369; rs4113133; rs12115836; rs635087; rs528866; rs12684849; rs7866650; rs11792211; rs28621580; rs616451; rs34101061; rs2945795; rs35007372; rs10668765; rs12000648; rs35098649; rs35802953; rs36080313; rs3990918; rs499480; rs34303194; rs2460137; rs11370106; rs4113134; rs35717974; rs13299030; rs2993965; rs10993253; rs13297617; rs33960007; rs12350611; rs11303048; rs639498; rs33934973; rs514561; rs11394532; rs34288791; rs7866757; rs34924732; rs2945797; rs9657694; rs579450; rs2945799; rs33949513; rs10125174; rs9697254; rs34525238; rs2679604; rs35338936; rs36092797; rs34691750; rs1934361; rs7469340; rs34740368; rs7871076; rs10584472; rs12683790; rs4113132; rs34355995; rs602606; rs35662608; rs7037602; rs10120467; rs34748035; rs34886780; rs7856539; rs12344649; rs35999121; rs35548100; rs479197; rs35405769; rs34114809; rs781649; rs12002400; rs35766092; rs34227394; rs35919971; rs34709246; rs13286145; rs12115199; rs34043734; rs7025414; rs36068498; rs4360350; rs2790389; rs7857750; rs10993255; rs878755; rs4744358; rs12004008; rs5899222; rs35892683; rs5899223; rs1042189; rs1062483; rs10761333; rs10761346; rs10993241; rs10993242; rs11795153; rs13295586; rs2274689; rs2679599; rs2679600; rs2772021; rs2772022; rs2987884; rs3780554; rs3802467; rs3802468; rs4743960; rs583365; rs601389; rs7048277; rs9695

# Metabolic_Enzyme_13_General_References:
9678974

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
6082

# Metabolic_Enzyme_14_Name:
Transaldolase

# Metabolic_Enzyme_14_Synonyms:
Not Available

# Metabolic_Enzyme_14_Gene_Name:
TALDO1

# Metabolic_Enzyme_14_Protein_Sequence:
>Transaldolase
MSSSPVKRQRMESALDQLKQFTTVVADTGDFHAIDEYKPQDATTNPSLILAAAQMPAYQE
LVEEAIAYGRKLGGSQEDQIKNAIDKLFVLFGAEILKKIPGRVSTEVDARLSFDKDAMVA
RARRLIELYKEAGISKDRILIKLSSTWEGIQAGKELEEQHGIHCNMTLLFSFAQAVACAE
AGVTLISPFVGRILDWHVANTDKKSYEPLEDPGVKSVTKIYNYYKKFSYKTIVMGASFRN
TGEIKALAGCDFLTISPKLLGELLQDNAKLVPVLSAKAAQASDLEKIHLDEKSFRWLHNE
DQMAVEKLSDGIRKFAADAVKLERMLTERMFNAENGK

# Metabolic_Enzyme_14_Number_of_Residues:
337

# Metabolic_Enzyme_14_Molecular_Weight:
37540

# Metabolic_Enzyme_14_Theoretical_pI:
6.80

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring aldehyde or ketonic groups
Function:  transaldolase activity
 ||
>>>
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  pentose-phosphate shunt
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_14_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway

# Metabolic_Enzyme_14_Pathway:
map00030  Pentose phosphate pathway

# Metabolic_Enzyme_14_Reaction:
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00923:Transaldolase

# Metabolic_Enzyme_14_Signals:
None

# Metabolic_Enzyme_14_Transmembrane_Regions:
None

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 2.2.1.2

# Metabolic_Enzyme_14_GenBank_ID_Protein:
2073541

# Metabolic_Enzyme_14_SwissProt_ID:
TALDO_HUMAN (P37837)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
TALDO1

# Metabolic_Enzyme_14_Geneatlas_id:
TALDO1

# Metabolic_Enzyme_14_hgnc_id:
HGNC:11559

# Metabolic_Enzyme_14_PDB_ID:
1F05

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Cytoplasm (Probable)

# Metabolic_Enzyme_14_Gene_Sequence:
>1014 bp
ATGTCGAGCTCACCCGTGAAGCGTCAGAGGATGGAGTCCGCGCTGGACCAGCTCAAGCAG
TTCACCACCGTGGTGGCCGACACGGGCGACTTCCACGCCATCGACGAGTACAAGCCCCAG
GATGCTACCACCAACCCGTCCCTGATCCTGGCCGCAGCACAGATGCCCGCTTACCAGGAG
CTGGTGGAGGAGGCGATTGCCTATGGCCGGAAGCTGGGCGGGTCACAAGAGGACCAGATT
AAAAATGCTATTGATAAACTTTTTGTGTTGTTTGGAGCAGAAATACTAAAGAAGATTCCG
GGCCGAGTATCCACAGAAGTAGACGCAAGGCTCTCCTTTGATAAAGATGCGATGGTGGCC
AGAGCCAGGCGGCTCATCGAGCTCTACAAGGAAGCTGGGATCAGCAAGGACCGAATTCTT
ATAAAGCTGTCATCAACCTGGGAAGGAATTCAGGCTGGAAAGGAGCTCGAGGAGCAGCAC
GGCATCCACTGCAACATGACGTTACTCTTCTCCTTCGCCCAGGCTGTGGCCTGTGCCGAG
GCGGGTGTGACCCTCATCTCCCCATTTGTTGGGCGCATCCTTGATTGGCATGTGGCAAAC
ACCGACAAGAAATCCTATGAGCCCCTGGAAGACCCTGGGGTAAAGAGTGTCACTAAAATC
TACAACTACTACAAGAAGTTTAGCTACAAAACCATTGTCATGGGCGCCTCCTTCCGCAAC
ACGGGCGAGATCAAAGCACTGGCCGGCTGTGACTTCCTCACCATCTCACCCAAGCTCCTG
GGAGAGCTGCTGCAGGACAACGCCAAGCTGGTGCCTGTGCTCTCAGCCAAGGCGGCCCAA
GCCAGTGACCTGGAAAAAATCCACCTGGATGAGAAGTCTTTCCGTTGGTTGCACAACGAG
GACCAGATGGCTGTGGAGAAGCTCTCTGACGGGATCCGCAAGTTTGCCGCTGATGCAGTG
AAGCTGGAGCGGATGCTGACAGAACGAATGTTCAATGCAGAGAATGGAAAGTAG

# Metabolic_Enzyme_14_GenBank_ID_Gene:
L19437

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_14_Locus:
11p15.5-p15.4

# Metabolic_Enzyme_14_SNPs:
rs3901233; rs7122767; rs7945912; rs3895063; rs4963163; rs7478765; rs9795013; rs11246300; rs9795064; rs3891028; rs11824894; rs7949508; rs11246302; rs7924831; rs4963124; rs7936322; rs10794338; rs2075545; rs1804555; rs11302; rs1804554; rs11550601; rs11550602; rs2234021; rs11550604; rs17850536; rs1050401; rs1131125; rs7939103; rs1131117; rs1804553; rs35677629; rs3932434; rs11246303; rs34225557; rs28793893; rs3891029; rs5789192; rs35873674; rs35787553; rs11246304; rs35714164; rs34361589; rs3891031; rs11246306; rs7927798; rs28842814; rs11246305; rs35724844; rs34721664; rs4083369; rs35736011; rs4083368; rs34103509; rs11246301; rs33944124; rs4083366; rs35377964; rs3929634; rs2234023; rs34347523; rs4083367; rs3891030; rs28455833; rs4083365; rs2234022; rs34220498; rs7933290; rs10794337; rs10902218; rs11246299; rs11502190; rs11502191; rs11602009; rs11823172; rs4963160; rs4963161; rs7930569; rs7937869; rs7952095

# Metabolic_Enzyme_14_General_References:
8300619; 9339383; 9524206; 10702296; 11283793

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
6083

# Metabolic_Enzyme_15_Name:
Fructose-1,6-bisphosphatase 1

# Metabolic_Enzyme_15_Synonyms:
D-fructose-1,6- bisphosphate 1-phosphohydrolase 1; FBPase 1

# Metabolic_Enzyme_15_Gene_Name:
FBP1

# Metabolic_Enzyme_15_Protein_Sequence:
>Fructose1,6bisphosphatase 1
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYAKDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ

# Metabolic_Enzyme_15_Number_of_Residues:
338

# Metabolic_Enzyme_15_Molecular_Weight:
36815

# Metabolic_Enzyme_15_Theoretical_pI:
6.99

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_15_Specific_Function:
D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate

# Metabolic_Enzyme_15_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00030  Pentose phosphate pathway;
 map00051  Fructose and mannose metabolism;
 map00710  Carbon fixation

# Metabolic_Enzyme_15_Reaction:
D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00316:FBPase

# Metabolic_Enzyme_15_Signals:
None

# Metabolic_Enzyme_15_Transmembrane_Regions:
None

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 3.1.3.11

# Metabolic_Enzyme_15_GenBank_ID_Protein:
182311

# Metabolic_Enzyme_15_SwissProt_ID:
F16P1_HUMAN (P09467)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
FBP1

# Metabolic_Enzyme_15_Geneatlas_id:
FBP1

# Metabolic_Enzyme_15_hgnc_id:
HGNC:3606

# Metabolic_Enzyme_15_PDB_ID:
1FTA

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_15_Gene_Sequence:
>1017 bp
ATGGCTGACCAGGCGCCCTTCGACACGGACGTCAACACCCTGACCCGCTTCGTCATGGAG
GAGGGCAGGAAGGCCCGCGGCACGGGCGAGTTGACCCAGCTGCTCAACTCGCTCTGCACA
GCAGTCAAAGCCATCTCTTCGGCGGTGCGCAAGGCGGGCATCGCGCACCTCTATGGCATT
GCTGGTTCTACCAACGTGACAGGTGATCAAGTTAAGAAGCTGGACGTCCTCTCCAACGAC
CTGGTTATGAACATGTTAAAGTCATCCTTTGCCACGTGTGTTCTCGTGTCAGAAGAAGAT
AAACACGCCATCATAGTGGAACCGGAGAAAAGGGGTAAATATGTGGTCTGTTTTGATCCC
CTTGATGGATCTTCCAACATCGATTGCCTTGTGTCCGTTGGAACCATTTTTGGCATCTAT
AGAAAGAAATCAACTGATGAGCCTTCTGAGAAGGATGCTCTGCAACCAGGCCGGAACCTG
GTGGCAGCCGGCTACGCACTGTATGGCAGTGCCACCATGCTGGTCCTTGCCATGGACTGT
GGGGTCAACTGCTTCATGCTGGACCCGGCCATCGGGGAGTTCATTTTGGTGGACAAGGAT
GTGAAGATAAAAAAGAAAGGTAAAATCTACAGCCTTAACGAGGCGTACGCTAAGGACTTT
GACCCTGCCGTCACTGAGTACATCCAGAGGAAGAAGTTCCCCCCAGATAATTCAGCTCCT
TATGGGGCCCGGTATGTGGGCTCCATGGTGGCTGATGTTCATCGCACTCTGGTCTACGGA
GGGATATTTCTGTACCCCGCTAACAAGAAGAGCCCCAATGGAAAGCTGAGACTGCTGTAC
GAATGCAACCCCATGGCCTACGTCATGGAGAAGGCTGGGGGAATGGCCACCACTGGGAAG
GAGGCCGTGTTAGACGTCATTCCCACAGACATTCACCAGAGGGCGCCGGTGATCTTGGGG
TCCCCCGACGACGTGCTCGAGTTCCTGAAGGTGTATGAGAAGCACTCTGCCCAGTGA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
L10320

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_15_Locus:
9q22.3

# Metabolic_Enzyme_15_SNPs:
rs1769259; rs2297085; rs16910744; rs1042144; rs1769257; rs9695; rs2274689; rs2296707; rs1042189; rs11351544; rs2993961; rs1999122; rs1754439; rs2297084; rs1536860; rs7025121; rs4129219; rs4743961; rs2987897; rs3739747; rs2993958; rs7044193; rs10761347; rs10123016; rs4129220; rs3824484; rs7872635; rs12238876; rs4744360; rs8192689; rs6479557; rs16910853; rs1769255; rs12000605; rs7867069; rs10993267; rs1999123; rs10123666; rs1977483; rs16910850; rs12000108; rs1536859; rs12005954; rs2296708; rs12551122; rs3780555; rs4075984; rs16937175; rs7019207; rs12005833; rs7020257; rs12000176; rs16910860; rs11999744; rs7044434; rs4744362; rs3780554; rs12553772; rs7034833; rs2993905; rs4584201; rs2993906; rs12006206; rs2993959; rs1754435; rs10993271; rs1769256; rs10993269; rs12000612; rs7468885; rs4744359; rs12002008; rs4526415; rs7041301; rs1410972; rs28369712; rs28369719; rs28382864; rs28745613; rs28402404; rs11794159; rs28369671; rs13291835; rs28402375; rs4323529; rs28369765; rs28402386; rs28369738; rs28745273; rs10993270; rs28369690; rs28402387; rs2993912; rs11794160; rs28369675; rs28402369; rs28382865; rs28369722; rs28402378; rs7873410; rs28402397; rs28369711; rs28369734; rs28369696; rs28369757; rs28402377; rs28369689; rs28369670; rs28382867; rs28369728; rs28369704; rs28369742; rs11794437; rs28369681; rs2993977; rs7025253; rs17847085; rs28402376; rs28369773; rs28402411; rs10124577; rs9657699; rs28369703; rs28369727; rs28369732; rs28369691; rs10119826; rs28402390; rs28402381; rs28369716; rs28369760; rs13296485; rs28369744; rs28369701; rs28402400; rs1769251; rs28402393; rs28369694; rs28369686; rs7041595; rs4744361; rs28369737; rs2993962; rs28369750; rs28382861; rs3935327; rs28369730; rs1754436; rs28402389; rs10993265; rs4077251; rs28369687; rs28369754; rs28369693; rs28369770; rs28402371; rs28382862; rs2149721; rs13284668; rs28745271; rs28369739; rs28402384; rs28402401; rs6479558; rs7858237; rs1754438; rs28402398; rs28402403; rs28369767; rs28382863; rs28402396; rs12343537; rs2993972; rs1754437; rs28402402; rs28369766; rs28745268; rs4574908; rs10761346; rs7028990; rs7031924; rs547834; rs7859489; rs7849320; rs10821375; rs12553205; rs10821374; rs583365; rs7859022; rs28369787; rs28369782; rs28369781; rs4111369; rs28382857; rs675998; rs28369780; rs28382858; rs28369786; rs7044650; rs12378132; rs41316538; rs28369761; rs28369776; rs1062483; rs28382860; rs28969550; rs28369751; rs34242023; rs28369775; rs28745269; rs11790850; rs28369705; rs28369682; rs11476729; rs10993261; rs28369706; rs28369740; rs28369674; rs28969549; rs35289872; rs28745270; rs28369764; rs28369748; rs28369723; rs28369735; rs28369759; rs11312408; rs28369683; rs11289183; rs28369758; rs34412800; rs28369718; rs28382866; rs28369741; rs11295175; rs28969548; rs28369680; rs28369697; rs33938516; rs34467125; rs28369688; rs28369669; rs28369763; rs28369729; rs28402372; rs35639838; rs33921126; rs28369721; rs28369774; rs35741860; rs28402374; rs5006547; rs28369717; rs5899226; rs36106567; rs28369672; rs11304867; rs28402412; rs28369679; rs5742194; rs13285331; rs28369692; rs11787609; rs35923612; rs12380393; rs3841715; rs28369733; rs28369678; rs28402406; rs33974346; rs35779797; rs28369668; rs28369762; rs28402394; rs28402370; rs34456573; rs28402413; rs28402391; rs28369756; rs28369673; rs28369745; rs35125972; rs28420852; rs11792428; rs28369699; rs28369720; rs10123908; rs10993272; rs11404445; rs28402395; rs28369743; rs28402405; rs2987898; rs4077249; rs12345842; rs28369731; rs2987896; rs35607886; rs28402410; rs28369736; rs33976316; rs3841716; rs28369726; rs28369715; rs5899227; rs28402408; rs35761183; rs34654698; rs11394817; rs11308338; rs28402382; rs28402380; rs10993258; rs28369676; rs28369747; rs10993264; rs28369725; rs11999699; rs11295174; rs35670528; rs5006546; rs34498455; rs28402407; rs28369684; rs10630708; rs10717568; rs35925714; rs4077250; rs28369710; rs10993259; rs28369755; rs28369768; rs34201110; rs28786777; rs35842026; rs41281160; rs28369677; rs35169885; rs10993260; rs28402383; rs28369749; rs34661913; rs28369707; rs28402392; rs12551086; rs28369753; rs28369709; rs10993263; rs12376081; rs34583977; rs28402379; rs7041552; rs28402373; rs10124580; rs28369695; rs28369713; rs28674671; rs28369702; rs4281163; rs33930464; rs28369752; rs28402399; rs3892819; rs28402409; rs4077248; rs28369685; rs28369700; rs10993262; rs35964382; rs28369724; rs10993268; rs28402388; rs28402385; rs1104796; rs28369746; rs11789488; rs28745272; rs5899224; rs17523168; rs28382856; rs11420151; rs5899225; rs28382859; rs28369778; rs34637502; rs28369784; rs28369783; rs34223546; rs3990925; rs28369779; rs35494386; rs28369777; rs28369785; rs34969066; rs28369788; rs10119050; rs10761348; rs10761350; rs10821376; rs10993275; rs10993276; rs10993277; rs10993280; rs11795153; rs12006551; rs12684841; rs2017136; rs2679599; rs2679600; rs2772021; rs2772022; rs2987900; rs4360350; rs4743960; rs601389; rs6479560; rs7035325; rs7043891; rs7864831; rs874248; rs878755

# Metabolic_Enzyme_15_General_References:
2842796; 8387495; 8135811; 7558035; 10222032; 7589895; 8382525; 7809062; 9382095

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5444

# Metabolic_Enzyme_16_Name:
Hexokinase-3

# Metabolic_Enzyme_16_Synonyms:
Hexokinase type III; HK III

# Metabolic_Enzyme_16_Gene_Name:
HK3

# Metabolic_Enzyme_16_Protein_Sequence:
>Hexokinase3
MDSIGSSGLRQGEETLSCSEEGLPGPSDSSELVQECLQQFKVTRAQLQQIQASLLGSMEQ
ALRGQASPAPAVRMLPTYVGSTPHGTEQGDFVVLELGATGASLRVLWVTLTGIEGHRVEP
RSQEFVIPQEVMLGAGQQLFDFAAHCLSEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRST
LISWTKGFRCSGVEGQDVVQLLRDAIRRQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVG
LVVDTGTNACYMEEARHVAVLDEDRGRVCVSVEWGSLSDDGALGPVLTTFDHTLDHESLN
PGAQRFEKMIGGLYLGELVRLVLAHLARCGVLFGGCTSPALLSQGSILLEHVAEMEDPST
GAARVHAILQDLGLSPGASDVELVQHVCAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQ
VAVATGGRVCERHPRFCSVLQGTVMLLAPECDVSLIPSVDGGGRGVAMVTAVAARLAAHR
RLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASSLRMLPTFVRATPDGSERGDFLA
LDLGGTNFRVLLVRVTTGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQ
SLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAI
VNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGD
DGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQ
RLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLC
GAGVAAVVEKIRGNRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSE
DGSGKGAALVTAVACRLAQLTRV

# Metabolic_Enzyme_16_Number_of_Residues:
923

# Metabolic_Enzyme_16_Molecular_Weight:
98921

# Metabolic_Enzyme_16_Theoretical_pI:
5.11

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Not Available

# Metabolic_Enzyme_16_Specific_Function:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_16_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism;
 map00521  Streptomycin biosynthesis;
 map00530  Aminosugars metabolism

# Metabolic_Enzyme_16_Reaction:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF00349:Hexokinase_1;
PF03727:Hexokinase_2

# Metabolic_Enzyme_16_Signals:
None

# Metabolic_Enzyme_16_Transmembrane_Regions:
None

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 2.7.1.1

# Metabolic_Enzyme_16_GenBank_ID_Protein:
1255788

# Metabolic_Enzyme_16_SwissProt_ID:
HXK3_HUMAN (P52790)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
HK3

# Metabolic_Enzyme_16_Geneatlas_id:
HK3

# Metabolic_Enzyme_16_hgnc_id:
HGNC:4925

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Not Available

# Metabolic_Enzyme_16_Gene_Sequence:
>2772 bp
ATGGACTCCATTGGGTCTTCAGGGTTGCGGCAGGGGGAAGAAACCCTGAGTTGCTCTGAG
GAGGGCTTGCCCGGGCCCTCAGACAGCTCAGAGCTGGTGCAGGAGTGCCTGCAGCAGTTC
AAGGTGACAAGGGCACAGCTACAGCAGATCCAAGCCAGCCTCTTGGGTTCCATGGAGCAG
GCGCTGAGGGGACAGGCCAGCCCTGCCCCTGCGGTCCGGATGCTGCCTACATACGTGGGG
TCCACCCCACATGGCACTGAGCAAGGAGACTTCGTGGTGCTGGAGCTGGGGGCCACAGGG
GCCTCACTGCGTGTTTTGTGGGTGACTCTAACTGGCATTGAGGGGCATAGGGTGGAGCCC
AGAAGCCAGGAGTTTGTGATCCCCCAAGAGGTGATGCTGGGTGCTGGCCAGCAGCTCTTT
GACTTTGCTGCCCACTGCCTGTCTGAGTTCCTGGATGCGCAGCCTGTGAACAAACAGGGT
CTGCAGCTTGGCTTCAGCTTCTCTTTCCCTTGTCACCAGACGGGCTTGGACAGGAGCACC
CTCATTTCCTGGACCAAAGGTTTTAGGTGCAGTGGTGTGGAAGGCCAGGATGTGGTCCAG
CTGCTGAGAGATGCCATTCGGAGGCAGGGGGCCTACAACATCGACGTGGTTGCTGTGGTG
AACGACACAGTGGGCACCATGATGGGCTGTGAGCCGGGGGTCAGGCCGTGTGAGGTTGGG
CTAGTTGTAGACACGGGCACCAACGCGTGTTACATGGAGGAGGCACGGCATGTGGCAGTG
CTGGACGAAGACCGGGGCCGCGTCTGCGTCAGCGTCGAGTGGGGCTCCTTAAGCGATGAT
GGGGCGCTGGGACCAGTGCTGACCACCTTCGACCATACCCTGGACCATGAGTCCCTGAAT
CCTGGTGCTCAGAGGTTTGAGAAGATGATCGGAGGCCTGTACCTGGGTGAGCTGGTGCGG
CTGGTGCTGGCTCACTTGGCCCGGTGTGGGGTCCTCTTTGGTGGCTGCACCTCCCCTGCC
CTGCTGAGCCAAGGCAGCATCCTCCTGGAACACGTGGCTGAGATGGAGGACCCCTCTACT
GGGGCAGCCCGTGTCCATGCTATCCTGCAGGACTTGGGCCTGAGCCCTGGGGCTTCGGAT
GTTGAGCTTGTGCAGCACGTCTGTGCGGCCGTGTGCACGCGGGCTGCCCAGCTCTGTGCT
GCCGCCCTGGCCGCTGTTCTCTCCTGCCTCCAGCACAGCCGGGAGCAACAAACACTCCAG
GTTGCTGTGGCCACCGGAGGCCGAGTGTGTGAGCGGCACCCCAGGTTCTGCAGCGTCCTG
CAGGGGACAGTGATGCTCCTGGCCCCGGAATGCGATGTCTCCTTAATCCCCTCTGTGGAT
GGTGGTGGCCGGGGAGTGGCGATGGTGACTGCTGTGGCTGCCCGTCTGGCTGCCCACCGG
CGCCTGCTGGAGGAGACCCTGGCCCCATTCCGGTTGAACCATGATCAACTGGCTGCGGTT
CAGGCACAGATGCGGAAGGCCATGGCCAAGGGGCTCCGAGGGGAGGCCTCCTCCCTTCGC
ATGCTGCCCACTTTCGTCCGGGCCACCCCTGACGGCAGCGAGCGAGGGGATTTCCTGGCC
CTGGACCTCGGGGGCACGAACTTCCGTGTCCTCCTGGTACGTGTGACCACAGGCGTGCAG
ATCACCAGCGAGATCTACTCCATTCCCGAGACTGTGGCCCAGGGTTCTGGGCAGCAGCTC
TTTGACCACATCGTGGACTGCATCGTGGACTTCCAGCAGAAGCAGGGCCTGAGCGGGCAG
AGCCTCCCACTGGGTTTTACCTTCTCCTTCCCATGTAGGCAGCTTGGCCTAGACCAGGGC
ATCCTCCTGAACTGGACCAAGGGTTTCAAGGCATCAGACTGCGAGGGCCAAGATGTCGTG
AGTCTGTTGCGGGAAGCCATCACTCGCAGACAGGCAGTGGAGCTGAATGTGGTTGCCATT
GTCAATGACACGGTGGGGACCATGATGTCCTGTGGCTATGAGGACCCCCGTTGCGAGATA
GGCCTCATTGTCGGAACCGGCACCAATGCCTGCTACATGGAGGAGCTCCGGAATGTGGCG
GGCGTGCCTGGGGACTCAGGCCGCATGTGCATCAACATGGAGTGGGGCGCCTTTGGGGAC
GATGGCTCTCTGGCCATGCTCAGCACCCGCTTTGATGCAAGTGTGGACCAGGCGTCCATC
AACCCCGGCAAGCAGAGGTTTGAAAAGATGATCAGCGGCATGTACCTGGGGGAGATCGTC
CGCCACATCCTTTTACATTTAACCAGCCTTGGCGTTCTCTTCCGGGGCCAGCAGATCCAG
CGCCTTCAGACCAGGGACATCTTCAAGACCAAGTTCCTCTCTGAGATCGAAAGTGACAGC
CTGGCCCTGCGGCAGGTCCGAGCCATCCTAGAGGATCTGGGGCTACCCCTGACCTCAGAT
GACGCCCTGATGGTGCTAGAGGTGTGCCAGGCTGTGTCCCAGAGGGCTGCCCAGCTCTGT
GGGGCGGGTGTAGCTGCCGTGGTGGAGAAGATCCGGGGGAACCGGGGCCTGGAAGAGCTG
GCAGTGTCTGTGGGGGTGGATGGAACGCTCTACAAGCTGCACCCGCGCTTCTCCAGCCTG
GTGGCGGCCACAGTGCGGGAGCTGGCCCCTCGCTGTGTGGTCACGTTCCTGCAGTCAGAG
GATGGGTCCGGCAAAGGTGCGGCCCTGGTCACCGCTGTTGCCTGCCGCCTTGCGCAGTTG
ACTCGTGTCTGA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
U51333

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_16_Locus:
5q35.2

# Metabolic_Enzyme_16_SNPs:
rs35610191; rs2278492; rs6875296; rs6861925; rs691141; rs691541; rs11135005; rs493578; rs691583; rs691057; rs522150; rs4976661; rs2278493; rs4976662; rs539822; rs691276; rs7716812; rs541807; rs12519232; rs479270; rs692200; rs10064961; rs3792729; rs12187462; rs691044; rs2278494; rs7736787; rs691693; rs691866; rs547798; rs3762971; rs812246; rs692129; rs2304514; rs35676647; rs34127573; rs494450; rs34497240; rs35226830; rs34468066; rs36002077; rs576380; rs34792080; rs36056969; rs6897020; rs35738781; rs4976631; rs35622796; rs4976663; rs691009; rs691473; rs34391089; rs3792730; rs35417166; rs691477; rs10056854; rs3762972; rs3762973; rs10543717; rs35180023; rs1043930; rs10475632; rs10475633; rs11953674; rs12422; rs1472920; rs2292255; rs2292256; rs2292257; rs2304515; rs2304516; rs2304517; rs2940531; rs2962835; rs2962844; rs2962845; rs3736431; rs3736432; rs3762974; rs475533; rs478253; rs490368; rs4976630; rs506370; rs690885; rs692011; rs9313744

# Metabolic_Enzyme_16_General_References:
8812439; 8717435

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
6084

# Metabolic_Enzyme_17_Name:
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

# Metabolic_Enzyme_17_Synonyms:
6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme; PFK-2/FBPase-2[Includes: 6- phosphofructo-2-kinase

# Metabolic_Enzyme_17_Gene_Name:
PFKFB2

# Metabolic_Enzyme_17_Protein_Sequence:
>6phosphofructo2kinase/fructose2,6biphosphatase 2
MSGASSSEQNNNSYETKTPNLRMSEKKCSWASYMTNSPTLIVMIGLPARGKTYVSKKLTR
YLNWIGVPTKVFNLGVYRREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEE
NGQIAVFDATNTTRERRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPE
RNRENVMEDFLKRIECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVY
YLMNIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVW
TSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRY
PGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTI
FKLTPVAYGCKVETIKLNVEAVNTHRDKPTNNFPKNQTPVRMRRNSFTPLSSSNTIRRPR
NYSVGSRPLKPLSPLRAQDMQEGAD

# Metabolic_Enzyme_17_Number_of_Residues:
505

# Metabolic_Enzyme_17_Molecular_Weight:
58477

# Metabolic_Enzyme_17_Theoretical_pI:
8.54

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  fructose metabolism
Process:  fructose 2,6-bisphosphate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_17_Specific_Function:
Synthesis and degradation of fructose 2,6-bisphosphate

# Metabolic_Enzyme_17_Pathway:
map00051  Fructose and mannose metabolism

# Metabolic_Enzyme_17_Reaction:
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF01591:6PF2K;
PF00300:PGAM

# Metabolic_Enzyme_17_Signals:
None

# Metabolic_Enzyme_17_Transmembrane_Regions:
None

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 2.7.1.105;EC 3.1.3.46

# Metabolic_Enzyme_17_GenBank_ID_Protein:
3090419

# Metabolic_Enzyme_17_SwissProt_ID:
F262_HUMAN (O60825)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
PFKFB2

# Metabolic_Enzyme_17_Geneatlas_id:
PFKFB2

# Metabolic_Enzyme_17_hgnc_id:
HGNC:8873

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Not Available

# Metabolic_Enzyme_17_Gene_Sequence:
>1515 bp
ATGTCTGGGGCATCTTCCTCAGAACAGAACAACAACAGCTATGAAACCAAAACCCCAAAT
CTTCGAATGTCAGAGAAGAAATCATGGGCCTCCTACATGACCAACTCCCCGACTCTGATC
GTTATGATTGGTTTGCCAGCCCGGGGTAAAACCTACGTGTCCAAGAAACTAACACGCTAC
CTCAACTGGATTGGAGTCCCCACCAAAGTGTTTAATCTTGGGGTGTATCGGCGTGAAGCA
GTCAAGTCCTATAAGTCCTACGACTTCTTTCGGCATGACAATGAGGAGGCCATGAAGATC
CGCAAACAGTGTGCTCTGGTGGCGCTGGAAGATGTTAAGGCGTATCTCACTGAGGAGAAT
GGTCAGATTGCGGTGTTTGATGCCACCAATACAACCCGGGAGAGGAGGGACATGATTTTG
AACTTTGCTGAACAGAATTCCTTCAAGGTATTCTTTGTGGAATCCGTCTGTGATGATCCT
GATGTCATTGCTGCCAATATTCTGGAGGTTAAGGTATCAAGCCCTGACTATCCTGAAAGG
AACAGAGAGAACGTGATGGAGGACTTCCTGAAGAGAATTGAATGCTACAAAGTTACCTAC
CGACCTCTTGACCCAGACAACTATGACAAGGATCTTTCTTTCATCAAGGTGATAAACGTG
GGCCAGCGATTTTTAGTCAACAGAGTCCAGGACTACATCCAGAGCAAGATAGTCTACTAC
CTCATGAATATCCACGTCCAGCCTCGCACCATTTACCTTTGCCGGCATGGAGAAAGCGAG
TTCAATCTCTTGGGGAAGATTGGGGGTGACTCTGGCCTCTCGGTGCGGGGAAAGCAGTTT
GCCCAAGCTCTAAGGAAATTTCTGGAGGAACAGGAAATAACAGACCTCAAAGTGTGGACA
AGCCAGTTGAAGAGGACCATACAGACTGCTGAATCTCTCGGGGTGCCCTATGAGCAGTGG
AAGATTCTGAATGAGATTGATGCTGGTGTGTGTGAAGAGATGACCTATGCAGAGATTGAG
AAACGGTACCCAGAAGAGTTTGCACTTCGAGATCAAGAGAAGTATCTGTATCGATATCCT
GGTGGGGAGTCATACCAGGACCTGGTGCAGCGGCTGGAGCCTGTCATCATGGAGCTGGAA
CGTCAGGGCAATGTCCTCGTCATCTCCCACCAGGCTGTCATGCGCTGCCTCCTGGCCTAC
TTCTTGGATAAGGGCGCAGATGAGCTACCATACTTGAGATGCCCTCTCCATACCATCTTC
AAACTTACTCCTGTGGCCTATGGGTGCAAAGTGGAAACAATTAAACTTAACGTGGAGGCT
GTGAACACGCACCGTGACAAGCCAACTAACAACTTCCCCAAGAACCAAACCCCTGTAAGG
ATGAGAAGGAACAGCTTTACGCCTCTGTCCAGTTCGAATACAATAAGGCGTCCAAGAAAT
TACAGTGTTGGGAGCCGGCCCCTCAAGCCCCTCAGCCCTCTCCGTGCCCAGGACATGCAA
GAAGGGGCCGACTAG

# Metabolic_Enzyme_17_GenBank_ID_Gene:
AJ005577

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_17_Locus:
1q31

# Metabolic_Enzyme_17_SNPs:
rs2629639; rs1565; rs1060287; rs4844565; rs6673422; rs12088135; rs6673109; rs3748671; rs6667268; rs3748672; rs1560; rs10494893; rs2629662; rs1060286; rs11120148; rs12079709; rs12036080; rs17258746; rs12083861; rs11120138; rs873140; rs1564879; rs2243816; rs2243821; rs2808462; rs923109; rs11120137; rs2808454; rs17020241; rs760418; rs2016939; rs2808461; rs2075863; rs11120132; rs6660341; rs2075864; rs2842751; rs12088688; rs1843349; rs2247227; rs12084230; rs11586970; rs11585800; rs11587070; rs17020177; rs2808463; rs2808459; rs2883211; rs17020154; rs17020246; rs2808460; rs3122006; rs2842752; rs2294151; rs10577264; rs34918838; rs11444254; rs34532886; rs2808450; rs12087244; rs2808451; rs4279857; rs34554658; rs36037469; rs10613251; rs11410821; rs35255963; rs35851029; rs7533742; rs2842743; rs12091658; rs2842742; rs11442656; rs1061958; rs7533554; rs34234509; rs34494079; rs10578737; rs4844566; rs2842746; rs2808457; rs7537730; rs7518420; rs2808452; rs4996700; rs12733385; rs12729226; rs9651116; rs34093184; rs2842745; rs11450882; rs12728574; rs35500343; rs35425352; rs35800462; rs4142864; rs34799554; rs2629655; rs5780372; rs35520337; rs11352964; rs2842744; rs2842750; rs35522351; rs11586959; rs28715239; rs12135736; rs34950946; rs2808453; rs3790620; rs34296817; rs2086949; rs11453040; rs36076002; rs34461407; rs2629654; rs4030464; rs34671041; rs2629651; rs2086950; rs2075865; rs35699697; rs12760145; rs3943180; rs2629657; rs2086948; rs2054778; rs2808456; rs34354164; rs11585761; rs12744287; rs2629660; rs11585791; rs34135276; rs2842749; rs2629656; rs34590725; rs35834042; rs4520420; rs2629653; rs35879866; rs12134333; rs2842748; rs2629659; rs2808455; rs12038734; rs2629652; rs2842747; rs2629658; rs2808458; rs4568836; rs35479991; rs34078505; rs34955969; rs1052511; rs11120103; rs11120106; rs11120172; rs11120184; rs11802037; rs12032180; rs12045707; rs12046484; rs12068090; rs12088299; rs12088454; rs12123107; rs12137664; rs12711513; rs1385611; rs17258711; rs1872454; rs2054779; rs2054780; rs2101313; rs2306714; rs2353545; rs2495255; rs2629663; rs2629664; rs2629665; rs2629691; rs2741939; rs2808448; rs2808464; rs2842741; rs2842754; rs3123020; rs3123021; rs3123022; rs3123023; rs3123024; rs4142863; rs4142866; rs4431844; rs4844372; rs6670857; rs6678853; rs6690037; rs7524212; rs7525965; rs7526458; rs7536934; rs7555766

# Metabolic_Enzyme_17_General_References:
9652401; 11374908

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
6085

# Metabolic_Enzyme_18_Name:
Transketolase

# Metabolic_Enzyme_18_Synonyms:
TK

# Metabolic_Enzyme_18_Gene_Name:
TKT

# Metabolic_Enzyme_18_Protein_Sequence:
>Transketolase
MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKS
QDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDV
ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA
ILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIA
KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN
IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFI
ECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVS
IGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII
YNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPL
DRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAE
LLKMFGIDRDAIAQAVRGLITKA

# Metabolic_Enzyme_18_Number_of_Residues:
623

# Metabolic_Enzyme_18_Molecular_Weight:
67878

# Metabolic_Enzyme_18_Theoretical_pI:
7.73

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring aldehyde or ketonic groups
Function:  transketolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_18_Specific_Function:
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

# Metabolic_Enzyme_18_Pathway:
map00030  Pentose phosphate pathway;
 map00710  Carbon fixation;
 map01051  Biosynthesis of ansamycins

# Metabolic_Enzyme_18_Reaction:
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF02779:Transket_pyr;
PF02780:Transketolase_C;
PF00456:Transketolase_N

# Metabolic_Enzyme_18_Signals:
None

# Metabolic_Enzyme_18_Transmembrane_Regions:
None

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 2.2.1.1

# Metabolic_Enzyme_18_GenBank_ID_Protein:
37267

# Metabolic_Enzyme_18_SwissProt_ID:
TKT_HUMAN (P29401)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
TKT

# Metabolic_Enzyme_18_Geneatlas_id:
TKT

# Metabolic_Enzyme_18_hgnc_id:
HGNC:11834

# Metabolic_Enzyme_18_PDB_ID:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Not Available

# Metabolic_Enzyme_18_Gene_Sequence:
>1872 bp
ATGGAGAGCTACCACAAGCCTGACCAGCAGAAGCTGCAGGCCTTGAAGGACACGGCCAAC
CGCCTACGTATCAGCTCCATCCAGGCCTCCTCTGCGGCGGGCTCTGGCCACCCCACGTCA
TGCTGCAGCGCCGCAGTGATCATGGCTGTCCTCTTTTTCCACACCATGCGCTACAAGTCC
CAGGACCCCCGGAATCCGCACAATGACCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCC
ATCCTCTACGCGGTCTGGGCTGAAGCTGGTTTCCTGGCCGAGGCGGAGCTGCTGAACCTG
AGGAAGATCAGCTCCGACTTGGACGGGCACCCGGTCCCGAAACAAGCTTTCACCGACGTG
GCCACTGGCTCCCTGGGCCAGGGCCTCGGGGCCGCTTGTGGGATGGCCTACACCGGCAAA
TACTTCGACAAGGCCAGCTACCGAGTCTATTGCTTGCTGGGAGATGGGGAGCTGTCAGAG
GGCTCTGTATGGGAGGCCATGGCCTTCGCCAGCATCTATAAGCTGGACAACCTTGTGGCC
ATTCTAGACATCAATCGCCTGGGCCAGAGTGACCCGGCCCCGCTGCAGCACCAGATGGAC
ATCTACCAGAAGCGGTGCGAGGCCTTCGGTTGGCATGCCATCATCGTGGATGGACACAGC
GTGGAGGAGCTGTGCAAGGCCTTTGGCCAGGCCAAGCACCAGCCAACAGCCATCATTGCC
AAGACCTTCAAGGGCCGAGGGATCACGGGGGTAGAAGATAAGGAGTCTTGGCATGGGAAG
CCCCTCCCCAAAAACATGGCTGAGCAGATCATCCAGGAGATCTACAGCCAGATCCAGAGC
AAAAAGAAGATCCTGGCAACCCCTCCACAGGAGGACGCACCCTCAGTGGACATTGCCAAC
ATCCGCATGCCCAGCCTGCCCAGCTACAAAGTTGGGGACAAGATAGCCACCCGCAAGGCC
TACGGGCAGGCACTGGCCAAGCTGGGCCATGCCAGTGACCGCATCATCGCCCTGGATGGG
GACACCAAAAATTCCACCTTCTCGGAGATCTTCAAAAAGGAGCACCCGGACCGCTTCATC
GAGTGCTACATTGCCGAGCAGAACATGGTGAGCATCGCGGTGGGCTGTGCCACCCGCAAC
AGGACGGTGCCCTTCTGCAGCACTTTTGCAGCCTTCTTCACGCGGGCCTTTGACCAGATT
CGCATGGCGGCCATCTCCGAGAGCAACATCAACCTCTGCGGCTCCCACTGCGGCGTTTCC
ATCGGGGAAGACGGGGCCTCCCAGATGGCCCTAGAAGATCTGGCTATGTTTCGGTCAGTC
CCCACATCAACTGTCTTTTACCCAAGTGATGGCGTTGCTACAGAGAAGGCAGTGGAACTA
GCCGCCAATACAAAGGGTATCTGCTTCATCCGGACCAGCCGCCCAGAAAATGCCATCATC
TATAACAACAATGAGGACTTCCAGGTCGGACAAGCCAAGGTGGTCCTGAAGAGCAAGGAT
GACCAGGTGACCGTTATCGGGGCTGGGGTGACCCTGCACGAGGCCTTGGCCGCTGCCGAA
CTGCTGAAGAAAGAAAAGATCAACATCCGCGTGCTGGACCCCTTCACCATCAAGCCCCTG
GACAGAAAACTCATTCTCGACAGCGCTCGTGCCACCAAGGGCAGGATCCTCACCGTGGAG
GACCATTATTATGAAGGTGGCATTGGTGAGGCTGTGTCCAGTGCAGTAGTGGGCGAGCCT
GGCATCACTGTCACCCACCTGGCAGTTAACCGGGTACCAAGAAGTGGGAAGCCAGCTGAG
CTGCTGAAGATGTTTGGTATCGACAGGGATGCCATTGCACAAGCTGTGAGGGGCCTCATC
ACCAAGGCCTAG

# Metabolic_Enzyme_18_GenBank_ID_Gene:
X67688

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_18_Locus:
3p14.3

# Metabolic_Enzyme_18_SNPs:
rs17052920; rs3163; rs6785374; rs1051485; rs1051483; rs2035450; rs4267636; rs4687715; rs6768738; rs900494; rs3773745; rs10433616; rs968702; rs7628245; rs7633598; rs12493802; rs7650103; rs7610113; rs3773747; rs7633966; rs11720625; rs2306569; rs4687717; rs9850440; rs6787685; rs3773743; rs2279323; rs735940; rs9827244; rs7356056; rs11717767; rs2242301; rs3821691; rs17234092; rs11717712; rs3736154; rs2279321; rs9879195; rs3736153; rs3773742; rs12487632; rs728910; rs9820968; rs7631667; rs3816767; rs7649481; rs7647720; rs2358621; rs9858133; rs12630643; rs9864057; rs9284890; rs3773739; rs3773746; rs7609596; rs2242302; rs3736156; rs7627444; rs7640493; rs7617474; rs6445573; rs2242303; rs11130362; rs12635973; rs2279322; rs9846315; rs3773740; rs12629909; rs7646760; rs2242300; rs4687718; rs12633001; rs2884495; rs6793773; rs9826552; rs4687716; rs9820979; rs2279320; rs3773744; rs9858502; rs7625237; rs7630632; rs9830594; rs1545857; rs6782597; rs2077693; rs12494824; rs9818458; rs12487568; rs10433618; rs6793684; rs11719464; rs10433617; rs13101181; rs13075304; rs7612011; rs9311494; rs12633000; rs12485313; rs3736155; rs2242304; rs6445572; rs13074156; rs3773741; rs11130365; rs12632671; rs3736151; rs17306163; rs17030933; rs13093936; rs34466346; rs3162; rs11556003; rs11556004; rs4687714; rs1802929; rs11556002; rs11556006; rs41275537; rs34601275; rs2229693; rs1140826; rs1140825; rs11305678; rs35203736; rs12638638; rs34084206; rs11130364; rs9835964; rs10620591; rs34995533; rs35075155; rs10703271; rs35048890; rs10212420; rs34310421; rs41275543; rs2358620; rs7356096; rs6786157; rs34089717; rs10666288; rs13091081; rs10668063; rs35041022; rs12054426; rs28758191; rs34095201; rs9850314; rs1351703; rs35712428; rs41389846; rs35495179; rs35643056; rs34243738; rs5848979; rs5848978; rs12629312; rs7430638; rs35154296; rs9875011; rs9859430; rs41275539; rs35936646; rs9830895; rs34146825; rs13059189; rs7626730; rs35171987; rs10049441; rs35205801; rs34618710; rs35246063; rs41275541; rs3821692; rs33924283; rs41275535; rs41332244; rs3075727; rs34276819; rs35110726; rs9868820; rs35794580; rs34107310; rs34838231; rs7431404; rs11297416; rs3075723; rs9833188; rs10622320; rs9858049; rs1056082; rs3832231; rs1056076; rs35706165; rs1056083; rs9681418; rs35261010; rs11540529; rs11540530; rs17030930; rs17030934; rs11130358; rs11130367; rs11919567; rs12490667; rs12633545; rs12634987; rs13317770; rs17052954; rs17052957; rs1979491; rs34774173; rs4687573; rs6773409; rs6781629; rs7631103; rs7637556; rs7637934; rs7641951; rs7647990; rs7648309; rs931253; rs9852398

# Metabolic_Enzyme_18_General_References:
8419340; 12665801; 1567394

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5446

# Metabolic_Enzyme_19_Name:
Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2

# Metabolic_Enzyme_19_Synonyms:
Hexosephosphate aminotransferase 2; D-fructose-6- phosphate amidotransferase 2; GFAT 2; GFAT2

# Metabolic_Enzyme_19_Gene_Name:
GFPT2

# Metabolic_Enzyme_19_Protein_Sequence:
>Glucosaminefructose6phosphate aminotransferase isomerizing 2
MCGIFAYMNYRVPRTRKEIFETLIKGLQRLEYRGYDSAGVAIDGNNHEVKERHIQLVKKR
GKVKALDEELYKQDSMDLKVEFETHFGIAHTRWATHGVPSAVNSHPQRSDKGNEFVVIHN
GIITNYKDLRKFLESKGYEFESETDTETIAKLIKYVFDNRETEDITFSTLVERVIQQLEG
AFALVFKSVHYPGEAVATRRGSPLLIGVRSKYKLSTEQIPILYRTCTLENVKNICKTRMK
RLDSSACLHAVGDKAVEFFFASDASAIIEHTNRVIFLEDDDIAAVADGKLSIHRVKRSAS
DDPSRAIQTLQMELQQIMKGNFSAFMQKEIFEQPESVFNTMRGRVNFETNTVLLGGLKDH
LKEIRRCRRLIVIGCGTSYHAAVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFF
ISQSGETADTLLALRYCKDRGALTVGVTNTVGSSISRETDCGVHINAGPEIGVASTKAYT
SQFISLVMFGLMMSEDRISLQNRRQEIIRGLRSLPELIKEVLSLEEKIHDLALELYTQRS
LLVMGRGYNYATCLEGALKIKEITYMHSEGILAGELKHGPLALIDKQMPVIMVIMKDPCF
AKCQNALQQVTARQGRPIILCSKDDTESSKFAYKTIELPHTVDCLQGILSVIPLQLLSFH
LAVLRGYDVDFPRNLAKSVTVE

# Metabolic_Enzyme_19_Number_of_Residues:
682

# Metabolic_Enzyme_19_Molecular_Weight:
76932

# Metabolic_Enzyme_19_Theoretical_pI:
7.40

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
Function:  glutamine-fructose-6-phosphate transaminase (isomerizing) activity
 ||
>>>
Process:  carbohydrate metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  carbohydrate biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_19_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_19_Specific_Function:
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins

# Metabolic_Enzyme_19_Pathway:
map00251  Glutamate metabolism;
 map00530  Aminosugars metabolism

# Metabolic_Enzyme_19_Reaction:
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF00310:GATase_2;
PF01380:SIS

# Metabolic_Enzyme_19_Signals:
None

# Metabolic_Enzyme_19_Transmembrane_Regions:
None

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 2.6.1.16

# Metabolic_Enzyme_19_GenBank_ID_Protein:
4239883

# Metabolic_Enzyme_19_SwissProt_ID:
GFPT2_HUMAN (O94808)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
GFPT2

# Metabolic_Enzyme_19_Geneatlas_id:
GFPT2

# Metabolic_Enzyme_19_hgnc_id:
HGNC:4242

# Metabolic_Enzyme_19_PDB_ID:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Not Available

# Metabolic_Enzyme_19_Gene_Sequence:
>2049 bp
ATGTGCGGAATCTTTGCCTACATGAACTACAGAGTCCCCCGGACGAGGAAGGAGATCTTC
GAAACCCTCATCAAGGGCCTGCAGCGGCTGGAGTACAGAGGCTACGACTCGGCAGGTGTG
GCGATCGATGGGAATAATCACGAAGTCAAAGAAAGACACATTCAGCTGGTCAAGAAAAGG
GGGAAAGTCAAGGCTCTCGATGAAGAACTTTACAAACAAGACAGCATGGACTTAAAAGTG
GAGTTTGAGACACACTTCGGCATTGCCCACACGCGCTGGGCCACCCACGGGGTCCCCAGT
GCTGTCAACAGCCACCCTCAGCGCTCAGACAAAGGCAACGAATTTGTTGTCATCCACAAT
GGGATCATCACAAATTACAAAGATCTGAGGAAATTTCTGGAAAGCAAAGGCTACGAGTTT
GAGTCAGAAACAGATACAGAGACCATCGCCAAGCTGATTAAATATGTGTTCGACAACAGA
GAAACTGAGGACATTACGTTTTCAACGTTGGTCGAGAGAGTCATTCAGCAGTTGGAAGGT
GCATTCGCGCTGGTTTTCAAGAGTGTCCACTACCCAGGAGAAGCCGTTGCCACACGGAGA
GGCAGCCCCCTGCTCATCGGAGTCCGGAGCAAATACAAGCTCTCCACAGAACAGATCCCT
ATCTTATACAGGACGTGCACTCTGGAGAATGTGAAGAATATCTGTAAGACACGGATGAAG
AGGCTGGACAGCTCCGCCTGCCTGCATGCTGTGGGCGACAAGGCCGTGGAATTCTTCTTT
GCTTCTGATGCAAGCGCTATCATAGAGCACACCAACCGGGTCATCTTCCTGGAGGACGAT
GACATCGCCGCAGTGGCTGATGGGAAACTCTCCATTCACCGGGTCAAGCGCTCGGCCAGT
GATGACCCATCTCGAGCCATCCAGACCTTGCAGATGGAACTGCAGCAAATCATGAAAGGT
AACTTCAGTGCGTTTATGCAGAAGGAGATCTTCGAACAGCCAGAATCAGTTTTCAATACT
ATGAGAGGTCGGGTGAATTTTGAAACCAACACAGTGCTCCTGGGTGGCTTGAAGGACCAC
TTGAAGGAGATTCGACGATGCCGACGGCTCATCGTGATTGGCTGTGGAACCAGCTACCAC
GCTGCCGTGGCTACGCGGCAAGTTTTGGAGGAACTGACTGAGCTTCCTGTGATGGTTGAA
CTTGCTAGTGATTTTCTGGACAGGAACACACCTGTGTTCAGGGATGACGTTTGCTTTTTC
ATCAGCCAGTCAGGCGAGACCGCGGACACCCTCCTGGCGCTGCGCTACTGTAAGGACCGC
GGCGCTCTCACCGTGGGCGTCACCAACACCGTGGGCAGCTCCATCTCTCGCGAGACCGAC
TGCGGCGTCCACATCAACGCAGGGCCGGAGATCGGCGTGGCCAGCACCAAGGCTTATACC
AGTCAGTTCATCTCTCTGGTGATGTTTGGTTTGATGATGTCTGAAGACCGAATTTCACTA
CAAAACAGGAGGCAAGAGATCATCCGTGGCTTGAGATCTTTACCTGAGCTGATCAAGGAA
GTGCTGTCTCTGGAGGAGAAGATCCACGACTTGGCCCTGGAGCTCTACACGCAGAGATCG
CTGCTGGTGATGGGGCGGGGCTACAACTATGCCACCTGCCTGGAAGGAGCCCTGAAAATT
AAAGAGATAACCTACATGCACTCAGAAGGCATCCTGGCTGGGGAGCTGAAGCACGGGCCC
CTGGCACTGATTGACAAGCAGATGCCCGTCATCATGGTCATTATGAAGGATCCTTGCTTC
GCCAAATGCCAGAACGCCCTGCAGCAAGTCACGGCCCGCCAGGGTCGCCCCATTATACTG
TGCTCCAAGGACGATACTGAAAGTTCCAAGTTTGCGTATAAGACAATTGAGCTGCCCCAC
ACTGTGGACTGCCTCCAGGGCATCCTGAGCGTGATTCCGCTGCAGCTGCTGTCCTTCCAC
CTGGCTGTTCTCCGAGGATATGACGTTGACTTCCCCAGAAATCTGGCCAAGTCTGTAACT
GTGGAATGA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
AB016789

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_19_Locus:
5q34-q35

# Metabolic_Enzyme_19_SNPs:
rs2303007; rs2112594; rs1035411; rs1559113; rs6601109; rs2303012; rs729568; rs7720626; rs10043913; rs4700733; rs3763131; rs3828686; rs888924; rs729652; rs4700942; rs888922; rs878706; rs6891083; rs2303005; rs7715919; rs13179839; rs12521558; rs3828688; rs1559114; rs17080199; rs888926; rs7707082; rs17080201; rs4543227; rs6893693; rs11249702; rs12514698; rs2080959; rs2386859; rs9687074; rs4432844; rs1078646; rs2042225; rs7730414; rs2386855; rs11249704; rs888925; rs2080957; rs6874653; rs11249703; rs11960659; rs10794704; rs7719192; rs4700939; rs4700931; rs2386858; rs4700941; rs4700940; rs7701459; rs1035412; rs4566752; rs6879260; rs1007838; rs6893651; rs13164734; rs1008025; rs7715132; rs10903253; rs11249701; rs7725605; rs12654592; rs2080958; rs888927; rs12523555; rs3805703; rs2303010; rs2386854; rs4700932; rs6869637; rs3749788; rs1363517; rs11951669; rs11249699; rs6859159; rs2303008; rs2386856; rs2386857; rs10794705; rs12651762; rs10903252; rs11740631; rs17080196; rs9686940; rs4529151; rs4425468; rs4700933; rs4537018; rs6887811; rs13172268; rs11742980; rs12519247; rs4235511; rs6887820; rs6601111; rs12521640; rs13188590; rs12516159; rs2042224; rs2303011; rs9686363; rs11738309; rs4700736; rs11744256; rs11747494; rs11747298; rs1422574; rs878705; rs6874176; rs12521644; rs6601108; rs4323198; rs2080955; rs6864729; rs6601110; rs17080160; rs7730585; rs11249694; rs2303009; rs2386853; rs13158872; rs6887601; rs11745449; rs7727934; rs11960688; rs2892153; rs12518499; rs7447624; rs6871454; rs7706951; rs9686362; rs4700735; rs2080956; rs7704402; rs11960633; rs4627952; rs11953989; rs3805705; rs6873614; rs1422572; rs1422573; rs3841145; rs36046599; rs11557568; rs35765078; rs5873686; rs1801853; rs3080055; rs4700731; rs12654320; rs6881795; rs11249700; rs11282010; rs6896695; rs34735703; rs35987549; rs6874433; rs734090; rs28380364; rs34416707; rs35259770; rs7704535; rs11356791; rs34831746; rs34778234; rs35211599; rs35223258; rs3217233; rs28700193; rs4700732; rs12655822; rs12652060; rs34342936; rs35460637; rs6896556; rs35808074; rs4493635; rs34704166; rs11278352; rs11741142; rs4700935; rs2892151; rs28507693; rs11749513; rs6873632; rs36224110; rs11322913; rs4700936; rs3749789; rs12332177; rs11249696; rs4700734; rs1540381; rs34154535; rs28667546; rs10479468; rs11278350; rs7735562; rs35303775; rs6883213; rs6871472; rs35017920; rs5873683; rs4700937; rs4700943; rs5873685; rs10551893; rs28562930; rs2892152; rs11341578; rs10052131; rs3805704; rs28433941; rs10579752; rs34473901; rs35625998; rs36068774; rs34172114; rs11249698; rs6866561; rs34163399; rs34236296; rs12055278; rs28729800; rs34611349; rs34871146; rs6892511; rs35690024; rs4574507; rs13163031; rs34154763; rs9329105; rs35605149; rs13161805; rs5873684; rs11741959; rs34467703; rs34992800; rs13171554; rs35251405; rs28469539; rs6873631; rs11278351; rs10479571; rs4419558; rs4700934; rs3828687; rs34335690; rs13157758; rs34330028; rs34036795; rs1540382; rs6882022; rs28696251; rs10610483; rs968590; rs6872946; rs1422575; rs35515756; rs6879034; rs7724653; rs11744073; rs1964288; rs35832337; rs34184127; rs34016478; rs12173080; rs11249695; rs35674568; rs36114573; rs10689521; rs11249697; rs11748848; rs35861097; rs34123923; rs28719732; rs35451492; rs35581043; rs4700938; rs34004331; rs6867143; rs35331042; rs34253331; rs6878656; rs35975547; rs10674209; rs7449271; rs6870028; rs34808044; rs34118046; rs11742984; rs1363512; rs5873690; rs33964530; rs3841144; rs5873688; rs4572964; rs1363511; rs35485679; rs5873687; rs5024016; rs34264498; rs5873689; rs35956632; rs3812068; rs34522925; rs35864082; rs11452117; rs3841143; rs10041598; rs10054994; rs11748619; rs11748698; rs12520876; rs12652232; rs1363513; rs1363514; rs1363515; rs1363516; rs1559116; rs2277934; rs35809530; rs3749791; rs3749792; rs3749795; rs3749796; rs4235510; rs6884111; rs7703402; rs7711688; rs7725; rs7728986; rs880528; rs9329106

# Metabolic_Enzyme_19_General_References:
10198162

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
6086

# Metabolic_Enzyme_20_Name:
Glucose-6-phosphate isomerase

# Metabolic_Enzyme_20_Synonyms:
GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI; Neuroleukin; NLK; Sperm antigen 36; SA-36

# Metabolic_Enzyme_20_Gene_Name:
GPI

# Metabolic_Enzyme_20_Protein_Sequence:
>Glucose6phosphate isomerase
MAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLV
TEDVMRMLVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMP
EVNKVLDKMKSFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPR
VWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVA
KHFVALSTNTTKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGA
HWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAYFQQGDMESN
GKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGL
HHKILLANFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFT
KLTPFMLGALVAMYEHKIFVQGIIWDINSFDQWGVELGKQLAKKIEPELDGSAQVTSHDA
STNGLINFIKQQREARVQ

# Metabolic_Enzyme_20_Number_of_Residues:
558

# Metabolic_Enzyme_20_Molecular_Weight:
63148

# Metabolic_Enzyme_20_Theoretical_pI:
8.55

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  catalytic activity
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, interconverting aldoses and ketoses
Function:  glucose-6-phosphate isomerase activity
 ||
>>>
Process:  glucose catabolism
Process:  glycolysis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  gluconeogenesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_20_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_20_Specific_Function:
Neuroleukin is a neurotrophic factor for spinal and sensory neurons

# Metabolic_Enzyme_20_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00030  Pentose phosphate pathway;
 map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_20_Reaction:
D-glucose 6-phosphate = D-fructose 6-phosphate

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00342:PGI

# Metabolic_Enzyme_20_Signals:
None

# Metabolic_Enzyme_20_Transmembrane_Regions:
None

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 5.3.1.9

# Metabolic_Enzyme_20_GenBank_ID_Protein:
189238

# Metabolic_Enzyme_20_SwissProt_ID:
G6PI_HUMAN (P06744)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
GPI

# Metabolic_Enzyme_20_Geneatlas_id:
GPI

# Metabolic_Enzyme_20_hgnc_id:
HGNC:4458

# Metabolic_Enzyme_20_PDB_ID:
1NUH

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_20_Gene_Sequence:
>1677 bp
ATGGCCGCTCTCACCCGGGACCCCCAGTTCCAGAAGCTGCAGCAATGGTACCGCGAGCAC
CGCTCCGAGCTGAACCTGCGCCGCCTCTTCGATGCCAACAAGGACCGCTTCAACCACTTC
AGCTTGACCCTCAACACCAACCATGGGCATATCCTGGTGGATTACTCCAAGAACCTGGTG
ACGGAGGACGTGATGCGGATGCTGGTGGACTTGGCCAAGTCCAGGGGCGTGGAGGCCGCC
CGGGAGCGGATGTTCAATGGTGAGAAGATCAACTACACCGAGGGTCGAGCCGTGCTGCAC
GTGGCTCTGCGGAACCGGTCAAACACACCCATCCTGGTAGACGGCAAGGATGTGATGCCA
GAGGTCAACAAGGTTCTGGACAAGATGAAGTCTTTCTGCCAGCGTGTCCGGAGCGGTGAC
TGGAAGGGGTACACAGGCAAGACCATCACGGACGTCATCAACATTGGCATTGTCGGCTCC
GACCTGGGACCCCTCATGGTGACTGAAGCCCTTAAGCCATACTCTTCAGGAGGTCCCCGC
GTCTGGTATGTCTCCAACATTGATGGAACTCACATTGCCAAAACCCTGGCCCAGCTGAAC
CCGGAGTCCTCCCTGTTCATCATTGCCTCCAAGACCTTTACTACCCAGGAGACCATCACG
AATGCAGAGACGGCGAAGGAGTGGTTTCTCCAGGCGGCCAAGGATCCTTCTGCAGTGGCG
AAGCACTTTGTTGCCCTGTCTACTAACACAACCAAAGTGAAGGAGTTTGGAATTGACCCT
CAAAACATGTTCGAGTTCTGGGATTGGGTGGGAGGACGCTACTCGCTGTGGTCGGCCATC
GGACTCTCCATTGCCCTGCACGTGGGTTTTGACAACTTCGAGCAGCTGCTCTCGGGGGCT
CACTGGATGGACCAGCACTTCCGCACGACGCCCCTGGAGAAGAACGCCCCCGTCTTGCTG
GCCCTGCTGGGTATCTGGTACATCAACTGCTTTGGGTGTGAGACACACGCCATGCTGCCC
TATGACCAGTACCTGCACCGCTTTGCTGCGTACTTCCAGCAGGGCGACATGGAGTCCAAT
GGGAAATACATCACCAAATCTGGAACCCGTGTGGACCACCAGACAGGCCCCATTGTGTGG
GGGGAGCCAGGGACCAATGGCCAGCATGCTTTTTACCAGCTCATCCACCAAGGCACCAAG
ATGATACCCTGTGACTTCCTCATCCCGGTCCAGACCCAGCACCCCATACGGAAGGGTCTG
CATCACAAGATCCTCCTGGCCAACTTCTTGGCCCAGACAGAGGCCCTGATGAGGGGAAAA
TCGACGGAGGAGGCCCGAAAGGAGCTCCAGGCTGCGGGCAAGAGTCCAGAGGACCTTGAG
AGGCTGCTGCCACATAAGGTCTTTGAAGGAAATCGCCCAACCAACTCTATTGTGTTCACC
AAGCTCACACCATTCATGCTTGGAGCCTTGGTCGCCATGTATGAGCACAAGATCTTCGTT
CAGGGCATCATCTGGGACATCAACAGCTTTGACCAGTGGGGAGTGGAGCTGGGAAAGCAG
CTGGCTAAGAAAATAGAGCCTGAGCTTGATGGCAGTGCTCAAGTGACCTCTCACGACGCT
TCTACCAATGGGCTCATCAACTTCATCAAGCAGCAGCGCGAGGCCAGAGTCCAATAA

# Metabolic_Enzyme_20_GenBank_ID_Gene:
K03515

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_20_Locus:
19q13.1

# Metabolic_Enzyme_20_SNPs:
rs8191371; rs2230294; rs1864139; rs8191382; rs1062480; rs1801015; rs8191416; rs34604585; rs2278266; rs2377572; rs7248411; rs8105184; rs8191393; rs4290576; rs8108038; rs8191381; rs8191385; rs2301263; rs8191399; rs4806015; rs8191361; rs8191425; rs3786884; rs1135465; rs7408956; rs8191378; rs8191424; rs8191372; rs8191394; rs8191410; rs8191403; rs8191364; rs8191376; rs8191426; rs8191387; rs10412725; rs8191398; rs10412410; rs8191360; rs7251297; rs10420957; rs8191412; rs8191404; rs8191419; rs8191363; rs8191390; rs2099099; rs8191389; rs8191374; rs8191392; rs8191409; rs16969249; rs8191380; rs8191400; rs10402604; rs8191377; rs11882260; rs8191396; rs8191405; rs10402237; rs8191369; rs8191414; rs7259394; rs8191362; rs11883310; rs10414598; rs11084765; rs8191368; rs8191365; rs8191386; rs8191420; rs8191406; rs7253813; rs8191397; rs8108083; rs4619515; rs8191429; rs8191356; rs7248970; rs11548996; rs11549002; rs1138409; rs1139447; rs34306618; rs11548997; rs11549000; rs11549001; rs1139454; rs11548998; rs35307979; rs8191359; rs3202337; rs1138438; rs7250027; rs34523056; rs8191421; rs12981485; rs8191379; rs10417925; rs12980831; rs4538119; rs8107867; rs8191417; rs4328566; rs8191415; rs8191428; rs4131351; rs8191367; rs8191407; rs13345182; rs8191375; rs8191418; rs35236631; rs8191411; rs8191391; rs8191373; rs8103448; rs7508474; rs8191427; rs8191388; rs8191422; rs35036655; rs10414626; rs34357963; rs12151155; rs8191395; rs12609804; rs8191408; rs10403982; rs10403178; rs3815930; rs10410400; rs11667021; rs12609887; rs7258820; rs34693694; rs8104740; rs4131352; rs11430472; rs8191384; rs8191366; rs12980826; rs8191423; rs35856824; rs8191401; rs34364440; rs8191413; rs4545937; rs10410575; rs8191383; rs35979967; rs35528136; rs35716159; rs28609064; rs4355042; rs4131353; rs34872723; rs8110617; rs35852790; rs35137793; rs36041853; rs11670783; rs8191402; rs12608465; rs34158809; rs35580817; rs2016292; rs10671976; rs36206350; rs10408512; rs12979474; rs36206349; rs34098176; rs8191358; rs10411051; rs12609911; rs1465432; rs1559195; rs1862489; rs2161473; rs2217327; rs416602; rs422732; rs580391

# Metabolic_Enzyme_20_General_References:
10727272; 2387591; 3352745; 8499925; 7989588; 8822952; 8822954; 9446754; 9856489

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
5448

# Metabolic_Enzyme_21_Name:
Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1

# Metabolic_Enzyme_21_Synonyms:
Hexosephosphate aminotransferase 1; D-fructose-6- phosphate amidotransferase 1; GFAT 1; GFAT1

# Metabolic_Enzyme_21_Gene_Name:
GFPT1

# Metabolic_Enzyme_21_Protein_Sequence:
>Glucosaminefructose6phosphate aminotransferase isomerizing 1
MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWEANACKIQLI
KKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIV
IHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQ
LEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTRW
GSQGERGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVA
AVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRG
RVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELAS
DFLDRNTPVFRDDVCFFLSQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGV
HINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLS
MDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLAL
VDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVD
CLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE

# Metabolic_Enzyme_21_Number_of_Residues:
699

# Metabolic_Enzyme_21_Molecular_Weight:
78808

# Metabolic_Enzyme_21_Theoretical_pI:
7.11

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
Function:  glutamine-fructose-6-phosphate transaminase (isomerizing) activity
 ||
>>>
Process:  carbohydrate metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  carbohydrate biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_21_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_21_Specific_Function:
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins

# Metabolic_Enzyme_21_Pathway:
map00251  Glutamate metabolism;
 map00530  Aminosugars metabolism

# Metabolic_Enzyme_21_Reaction:
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF00310:GATase_2;
PF01380:SIS

# Metabolic_Enzyme_21_Signals:
None

# Metabolic_Enzyme_21_Transmembrane_Regions:
None

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 2.6.1.16

# Metabolic_Enzyme_21_GenBank_ID_Protein:
183082

# Metabolic_Enzyme_21_SwissProt_ID:
GFPT1_HUMAN (Q06210)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
GFPT1

# Metabolic_Enzyme_21_Geneatlas_id:
GFPT1

# Metabolic_Enzyme_21_hgnc_id:
HGNC:4241

# Metabolic_Enzyme_21_PDB_ID:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Not Available

# Metabolic_Enzyme_21_Gene_Sequence:
>2046 bp
ATGTGTGGTATATTTGCTTACTTAAACTACCATGTTCCTCGAACGAGACGAGAAATCCTG
GAGACCCTAATCAAAGGCCTTCAGAGACTGGAGTACAGAGGATATGATTCTGCTGGTGTG
GGATTTGATGGAGGCAATGATAAAGATTGGGAAGCCAATGCCTGCAAAACCCAGCTTATT
AAGAAGAAAGGAAAAGTTAAGGCACTGGATGAAGAAGTTCACAAGCAACAAGATATGGAT
TTGGATATAGAATTTGATGTACACCTTGGAATAGCTCATACCCGTTGGGCAACACATGGA
GAACCCAGTCCTGTCAATAGCCACCCCCAGCGCTCTGATAAAAATAATGAATTTATCGTT
ATTCACAATGGAATCATCACCAACTACAAAGACTTGAAAAAGTTTTTGGAAAGCAAAGGC
TATGACTTCGAATCTGAAACAGACACAGAGACAATTGCCAAGCTCGTTAAGTATATGTAT
GACAATCGGGAAAGTCAAGATACCAGCTTTACTACCTTGGTGGAGAGAGTTATCCAACAA
TTGGAAGGTGCTTTTGCACTTGTGTTTAAAAGTGTTCATTTTCCCGGGCAAGCAGTTGGC
ACAAGGCGAGGTAGCCCTCTGTTGATTGGTGTACGGAGTGAACATAAACTTTCTACTGAT
CACATTCCTATACTCTACAGAACAGGCAAAGACAAGAAAGGAAGCTGCAATCTCTCTCGT
GTGGACAGCACAACCTGCCTTTTCCCGGTGGAAGAAAAAGCAGTGGAGTATTACTTTGCT
TCTGATGCAAGTGCTGTCATAGAACACACCAATCGCGTCATCTTTCTGGAAGATGATGAT
GTTGCAGCAGTAGTGGATGGACGTCTTTCTATCCATCGAATTAAACGAACTGCAGGAGAT
CACCCCGGACGAGCTGTGCAAACACTCCAGATGGAACTCCAGCAGATCATGAAGGGCAAC
TTCAGTTCATTTATGCAGAAGGAAATATTTGAGCAGCCAGAGTCTGTCGTGAACACAATG
AGAGGAAGAGTCAACTTTGATGACTATACTGTGAATTTGGGTGGTTTGAAGGATCACATA
AAGGAGATCCAGAGATGCCGGCGTTTGATTCTTATTGCTTGTGGAACAAGTTACCATGCT
GGTGTAGCAACACGTCAAGTTCTTGAGGAGCTGACTGAGTTGCCTGTGATGGTGGAACTA
GCAAGTGACTTCCTGGACAGAAACACACCAGTCTTTCGAGATGATGTTTGCTTTTTCCTT
AGTCAATCAGGTGAGACAGCAGATACTTTGATGGGTCTTCGTTACTGTAAGGAGAGAGGA
GCTTTAACTGTGGGGATCACAAACACAGTTGGCAGTTCCATATCACGGGAGACAGATTGT
GGAGTTCATATTAATGCTGGTCCTGAGATTGGTGTGGCCAGTACAAAGGCTTATACCAGC
CAGTTTGTATCCCTTGTGATGTTTGCCCTTATGATGTGTGATGATCGGATCTCCATGCAA
GAAAGACGCAAAGAGATCATGCTTGGATTGAAACGGCTGCCTGATTTGATTAAGGAAGTA
CTGAGCATGGATGACGAAATTCAGAAACTAGCAACAGAACTTTATCATCAGAAGTCAGTT
CTGATAATGGGACGAGGCTATCATTATGCTACTTGTCTTGAAGGGGCACTGAAAATCAAA
GAAATTACTTATATGCACTCTGAAGGCATCCTTGCTGGTGAATTGAAACATGGCCCTCTG
GCTTTGGTGGATAAATTGATGCCTGTGATCATGATCATCATGAGAGATCACACTTATGCC
AAGTGTCAGAATGCTCTTCAGCAAGTGGTTGCTCGGCAGGGGCGGCCTGTGGTAATTTGT
GATAAGGAGGATACTGAGACCATTAAGAACACAAAAAGAACGATCAAGGTGCCCCACTCA
GTGGACTGCTTGCAGGGCATTCTCAGCGTGATCCCTTTACAGTTGCTGGCTTTCCACCTT
GCTGTGCTGAGAGGCTATGATGTTGATTTCCCACGGAATCTTGCCAAATCTGTGACTGTA
GAGTGA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
M90516

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_21_Locus:
2p13

# Metabolic_Enzyme_21_SNPs:
rs17312042; rs2667; rs4546050; rs6546505; rs4447647; rs4549136; rs6546503; rs4369907; rs5013338; rs4340572; rs6546509; rs6722492; rs4416261; rs7571096; rs6546510; rs4078089; rs4625963; rs6747247; rs6724567; rs6728752; rs4452195; rs7578692; rs4524165; rs6757629; rs4592895; rs4428054; rs6713705; rs13419122; rs6742733; rs7579556; rs11887344; rs6705452; rs12713677; rs6720415; rs4410327; rs6738707; rs10164798; rs10195277; rs7424361; rs4473430; rs6755522; rs6705460; rs12473304; rs6546504; rs7579871; rs10167510; rs6753031; rs10200376; rs7589430; rs6725340; rs6546508; rs6713769; rs6747567; rs4479469; rs11883756; rs10170655; rs7607351; rs7578988; rs13394686; rs6728202; rs13422656; rs7596845; rs12613765; rs12466648; rs6724874; rs13429805; rs10172351; rs7592803; rs7596544; rs6747389; rs4410328; rs7558839; rs4353693; rs6727392; rs9808023; rs6546511; rs10198171; rs10198150; rs35703185; rs17854372; rs1803646; rs6729690; rs13000879; rs34022306; rs35228072; rs13406505; rs7340311; rs11486522; rs13394893; rs35072608; rs34318105; rs9678510; rs34621378; rs10191300; rs7597098; rs5831970; rs10180609; rs11422876; rs7589970; rs34846508; rs9808097; rs35846165; rs10560036; rs34865102; rs34139905; rs34723803; rs7599338; rs34152035; rs13016371; rs35042449; rs35969126; rs13410401; rs34496195; rs34090357; rs11689204; rs13389936; rs35577873; rs13424862; rs4402813; rs10602884; rs13003042; rs13026217; rs34686385; rs13026795; rs7595415; rs6724399; rs11439496; rs6546507; rs35454289; rs11420444; rs11296709; rs13026027; rs34170709; rs35630408; rs13026609; rs13385161; rs35356748; rs13393162; rs7340310; rs35112325; rs34121282; rs12474957; rs12997521; rs13002847; rs10689762; rs11360015; rs11489048; rs35106317; rs11464823; rs28678591; rs11458758; rs34325453; rs13431730; rs6759162; rs10700322; rs13019789; rs10175215; rs11363421; rs34091929; rs35658587; rs13392380; rs10714224; rs35392088; rs13408397; rs5831971; rs35105753; rs13430064; rs6721745; rs35636082; rs10203225; rs13026233; rs35631369; rs13026810; rs10203394; rs34754512; rs34527712; rs34022172; rs35777075; rs13411452; rs11889454; rs4302256; rs10715095; rs10674804; rs35619705; rs10196679; rs11883798; rs10172902; rs11407687; rs34806849; rs35361967; rs34509988; rs13388542; rs34477438; rs4402814; rs35366403; rs13385290; rs17552724; rs10185336; rs3182038; rs13385291; rs7568674; rs36057221; rs34799398; rs10170036; rs12615384; rs13751; rs35380455; rs4493312; rs4535086; rs5017686; rs7559627; rs7586596

# Metabolic_Enzyme_21_General_References:
1460020; 11679416

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
6009

# Metabolic_Enzyme_22_Name:
6-phosphofructokinase type C

# Metabolic_Enzyme_22_Synonyms:
Phosphofructokinase 1; Phosphohexokinase; Phosphofructo-1-kinase isozyme C; PFK-C; 6- phosphofructokinase, platelet type

# Metabolic_Enzyme_22_Gene_Name:
PFKP

# Metabolic_Enzyme_22_Protein_Sequence:
>6phosphofructokinase type 
CMDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYF
IYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGI
TNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFC
GTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFL
PESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYD
TRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLME
CVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVG
APAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGT
KRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATV
SNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAG
ADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGK
GVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICV
LGISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHV
QPWSV

# Metabolic_Enzyme_22_Number_of_Residues:
784

# Metabolic_Enzyme_22_Molecular_Weight:
85597

# Metabolic_Enzyme_22_Theoretical_pI:
7.60

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  phosphofructokinase activity
Function:  6-phosphofructokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  protein complex
Component:  6-phosphofructokinase complex
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_22_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_22_Specific_Function:
ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

# Metabolic_Enzyme_22_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00030  Pentose phosphate pathway;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism

# Metabolic_Enzyme_22_Reaction:
ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF00365:PFK

# Metabolic_Enzyme_22_Signals:
None

# Metabolic_Enzyme_22_Transmembrane_Regions:
None

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 2.7.1.11

# Metabolic_Enzyme_22_GenBank_ID_Protein:
560105

# Metabolic_Enzyme_22_SwissProt_ID:
K6PP_HUMAN (Q01813)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
PFKP

# Metabolic_Enzyme_22_Geneatlas_id:
PFKP

# Metabolic_Enzyme_22_hgnc_id:
HGNC:8878

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Not Available

# Metabolic_Enzyme_22_Gene_Sequence:
>2355 bp
ATGGACGCGGACGACTCCCGGGCCCCCAAGGGCTCCTTGCGGAAGTTCCTGGAGCACCTC
TCCGGGGCCGGCAAGGCCATCGGCGTGCTGACCAGCGGCGGGGATGCTCAAGGTATGAAC
GCTGCCGTCCGTGCCGTGGTGCGCATGGGTATCTACGTGGGGGCCAAGGTGTACTTCATC
TACGAGGGCTACCAGGGCATGGTGGACGGAGGCTCAAACATCGCAGAGGCCGACTGGGAG
AGTGTCTCCAGCATCCTGCAAGTGGGCGGGACGATCATTGGCAGTGCGCGGTGCCAGGCC
TTCCGCACGCGGGAAGGCCGCCTGAAGGCTGCTTGCAACCTGCTGCAGCGCGGCATCACC
AACCTGTGTGTGATCGGCGGGGACGGGAGCCTCACCGGGGCCAACCTCTTCCGGAAGGAG
TGGAGTGGGCTGCTGGAGGAGCTGGCCAGGAACGGCCAGATCGATAAGGAGGCCGTGCAG
AAGTACGCCTACCTCAACGTGGTGGGCATGGTGGGCTCCATCGACAATGATTTCTGCGGC
ACCGACATGACCATCGGCACGGACTCCGCCCTGCACAGGATCATCGAGGTCGTCGACGCC
ATCATGACCACGGCCCAGAGCCACCAGAGGACCTTCGTTCTGGAGGTGATGGGACGACAC
TGTGGGTACCTGGCCCTGGTGAGTGCCTTGGCCTGCGGTGCGGACTGGGTGTTCCTTCCA
GAATCTCCACCAGAGGAAGGCTGGGAGGAGCAGATGTGTGTCAAACTCTCGGAGAACCGT
GCCCGGAAAAAAAGGCTGAATATTATTATTGTGGCTGAAGGAGCAATTGATACCCAAAAT
AAACCCATCACCTCTGAGAAAATCAAAGAGCTTGTCGTCACGCAGCTGGGCTATGACACA
CGTGTGACCATCCTCGGGCACGTGCAGAGAGGAGGGACCCCTTCGGCATTCGACAGGATC
TTGGCCAGCCGCATGGGAGTGGAGGCAGTCATCGCCTTGCTAGAGGCCACCCCGGACACC
CCAGCTTGCGTCGTGTCACTGAACGGGAACCACGCCGTGCGCCTGCCGCTGATGGAGTGC
GTGCAGATGACTCAGGATGTGCAGAAGGCGATGGACGAGAGGAGATTTCAAGATGCGGTT
CGACTCCGAGGGAGGAGCTTTGCGGGCAACCTGAACACCTACAAGCGACTTGCCATCAAG
CTGCCGGATGATCAGATCCCAAAGACCAATTGCAACGTAGCTGTCATCAACGTGGGGGCA
CCCGCGGCTGGGATGAACGCGGCCGTACGCTCAGCTGTGCGCGTGGGCATTGCCGACGGC
CACAGGATGCTCGCCATCTATGATGGCTTTGACGGCTTCGCCAAGGGCCAGATCAAAGAA
ATCGGCTGGACAGATGTCGGGGGCTGGACCGGCCAAGGAGGCTCCATTCTTGGGACAAAA
CGCGTTCTCCCGGGGAAGTACTTGGAAGAGATCGCCACACAGATGCGCACGCACAGCATC
AACGCGCTGCTGATCATCGGTGGATTCGAGGCCTACCTGGGACTCCTGGAGCTGTCAGCC
GCCCGGGAGAAGCACGAGGAGTTCTGTGTCCCCATGGTCATGGTTCCCGCTACTGTGTCC
AACAATGTGCCGGGTTCCGATTTCAGCATCGGGGCAGACACCGCCCTGAACACTATCACC
GACACCTGCGACCGCATCAAGCAGTCCGCCAGCGGAACCAAGCGGCGCGTGTTCATCATC
GAGACCATGGGCGGCTACTGTGGCTACCTGGCCAACATGGGGGGGCTCGCGGCCGGAGCT
GATGCCGCATACATTTTCGAAGAGCCCTTCGACATCAGGGATCTGCAGTCCAACGTGGAG
CACCTGACGGAGAAAATGAAGACCACCATCCAGAGAGGCCTTGTGCTCAGAAATGAGAGC
TGCAGTGAAAACTACACCACCGACTTCATTTACCAGCTGTATTCAGAAGAGGGCAAAGGC
GTGTTTGACTGCAGGAAGAACGTGCTGGGTCACATGCAGCAGGGTGGGGCACCCTCTCCA
TTTGATAGAAACTTTGGAACCAAAATCTCTGCCAGAGCTATGGAGTGGATCACTGCAAAA
CTCAAGGAGGCCCGGGGCAGAGGAAAAAAATTTACCACCGATGATTCCATTTGTGTGCTG
GGAATAAGCAAAAGAAACGTTATTTTTCAACCTGTGGCAGAGCTGAAGAAGCAAACGGAT
TTTGAGCACAGGATTCCCAAAGAACAGTGGTGGCTCAAGCTACGGCCCCTCATGAAAATC
CTGGCCAAGTACAAGGCCAGCTATGACGTGTCGGACTCAGGCCAGCTGGAACATGTGCAG
CCCTGGAGTGTCTGA

# Metabolic_Enzyme_22_GenBank_ID_Gene:
D25328

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_22_Locus:
10p15.3-p15.2

# Metabolic_Enzyme_22_SNPs:
rs2306302; rs1132173; rs4881086; rs12572717; rs1052333; rs1052309; rs11251721; rs11542779; rs11542777; rs11542780; rs1052337; rs35828349; rs4881080; rs3816699; rs9063; rs1052929; rs1053000; rs542; rs543; rs541; rs7673; rs3816712; rs2388564; rs867274; rs2388595; rs2306294; rs2306297; rs7901550; rs2306310; rs7913237; rs2279211; rs10508245; rs2388510; rs6602029; rs2892550; rs3814587; rs4881099; rs7080240; rs6602028; rs2306312; rs3829915; rs2306304; rs7896691; rs7086721; rs7923989; rs7916889; rs6602030; rs2279215; rs6602027; rs4881091; rs2306311; rs2279212; rs7922072; rs4391741; rs2388594; rs10795000; rs4611105; rs3814590; rs730141; rs9423693; rs7100185; rs4881101; rs4390256; rs2306305; rs4881084; rs2279208; rs882849; rs7913473; rs7902549; rs7096334; rs4545444; rs7082863; rs2306299; rs7924111; rs4381274; rs4880592; rs10903969; rs9630129; rs7075489; rs7096442; rs12268267; rs11819604; rs11251702; rs7076989; rs2306293; rs12569790; rs11817505; rs12570754; rs7082524; rs17284739; rs9423690; rs2388565; rs4881105; rs4881098; rs10508246; rs7918368; rs11251694; rs10903970; rs4881074; rs10903959; rs4881085; rs4517415; rs2388566; rs7342021; rs2306309; rs7894036; rs10794999; rs4881075; rs12569846; rs7091322; rs10903967; rs9423462; rs10903972; rs11251727; rs2388569; rs7901589; rs11591441; rs3829914; rs4598574; rs3816698; rs4881093; rs9423474; rs11251724; rs3740613; rs2306307; rs2306314; rs9423467; rs7896260; rs10903974; rs2892554; rs4595438; rs4881079; rs2388567; rs17131897; rs3816701; rs9423466; rs11592061; rs11251697; rs7086902; rs11251741; rs2306316; rs3814588; rs12257705; rs10903962; rs7080058; rs11599851; rs7910054; rs17212803; rs872398; rs17132175; rs2306306; rs9423487; rs2306315; rs6602032; rs10903955; rs10903961; rs3814589; rs4306207; rs11818475; rs4881077; rs9423680; rs4881087; rs9423489; rs2279210; rs7075876; rs9423490; rs6602031; rs11251723; rs12762657; rs11812979; rs11251711; rs10903954; rs12776036; rs4881097; rs7083162; rs2279206; rs4269839; rs7094776; rs7903250; rs9423491; rs10751913; rs12253549; rs7915793; rs7906901; rs2388570; rs3842695; rs9804219; rs3829917; rs11251719; rs12572060; rs4881082; rs4256893; rs9423471; rs10903960; rs17132578; rs2279207; rs7091146; rs7896897; rs7071398; rs12415723; rs9423464; rs7918168; rs11251729; rs4880590; rs7902539; rs4999370; rs9804221; rs2388552; rs7907949; rs9423681; rs11251732; rs11251707; rs4881081; rs7900748; rs10795002; rs11815740; rs17285851; rs4881078; rs3829916; rs7896829; rs7074733; rs11251709; rs9423685; rs12247270; rs11598339; rs10903968; rs7898894; rs3740611; rs7900171; rs17135865; rs2279204; rs4271292; rs12412712; rs9423469; rs10430751; rs9423472; rs11251696; rs7915264; rs12769974; rs9423692; rs11592619; rs4881095; rs7913254; rs7094648; rs11251742; rs11251695; rs9423691; rs2306301; rs2279209; rs7090199; rs9423698; rs7909171; rs3816703; rs4469783; rs10751914; rs10903966; rs3740610; rs11818602; rs9423473; rs2279205; rs1107048; rs11251734; rs11251728; rs2388571; rs9423485; rs7076698; rs11251710; rs11591990; rs6602023; rs9423494; rs4391742; rs8181285; rs2388573; rs4424569; rs10795004; rs9423695; rs3829912; rs11595224; rs11251715; rs7088110; rs10903957; rs10903973; rs7916196; rs7893663; rs10795005; rs11251720; rs4881094; rs9423476; rs4881089; rs10903963; rs3829911; rs2388574; rs4881100; rs9423475; rs9423686; rs2279213; rs10903958; rs6602026; rs3842696; rs7901291; rs9423477; rs3740612; rs7896500; rs2279203; rs10751912; rs2388568; rs4281389; rs6602022; rs7079667; rs872399; rs11251730; rs9804296; rs9423697; rs4881090; rs9423492; rs2388551; rs11251693; rs11595461; rs3814591; rs4881088; rs11595530; rs9423689; rs12357621; rs11591423; rs12414599; rs7914782; rs12245370; rs12258216; rs7074889; rs10458792; rs10430770; rs2388592; rs12358995; rs3816700; rs10903953; rs10795003; rs7100037; rs11251733; rs12772110; rs4881083; rs6602024; rs4881092; rs9423470; rs9423479; rs3830218; rs10508244; rs2388550; rs7902685; rs7342119; rs4589191; rs2306308; rs2388563; rs4881106; rs12772817; rs7079217; rs2388562; rs41288721; rs11542782; rs11542778; rs34180069; rs17852638; rs41288715; rs11542781; rs3816704; rs3841604; rs11251743; rs34020709; rs9423465; rs11419779; rs12249060; rs9423481; rs11251716; rs12246252; rs35454947; rs10552241; rs10528387; rs12571307; rs2306318; rs7903389; rs4991347; rs35621470; rs2306303; rs34612453; rs11251703; rs36062383; rs41288731; rs41285619; rs41288717; rs35044971; rs36124101; rs34773391; rs7914040; rs10611976; rs36123078; rs10458791; rs35763309; rs7342088; rs35304719; rs7893811; rs34970131; rs10673964; rs9423483; rs7087044; rs11312438; rs9423682; rs35870724; rs41288727; rs7911657; rs9423480; rs11251712; rs35129023; rs11473992; rs35998692; rs34554786; rs7078002; rs10606109; rs10458790; rs12243817; rs35551233; rs10578594; rs41288713; rs4991348; rs34810963; rs6143743; rs2388572; rs10552310; rs11251726; rs9423482; rs7083310; rs11599643; rs11593072; rs33926028; rs9423463; rs6602025; rs12571292; rs4002022; rs35375917; rs34822234; rs34387880; rs41288719; rs11418900; rs34547664; rs34978134; rs5782687; rs10736966; rs5782680; rs10795006; rs10795001; rs7921605; rs11251717; rs34543032; rs11251705; rs4575170; rs2306317; rs4881096; rs11364694; rs41288729; rs9423684; rs35591312; rs5782685; rs3841457; rs11251708; rs34980049; rs34937212; rs10606110; rs7911305; rs3892593; rs7917172; rs34361470; rs7903088; rs4881076; rs11251704; rs9423461; rs35755098; rs34626444; rs35455312; rs7342001; rs2388591; rs36089632; rs9630123; rs5782686; rs4584487; rs10903964; rs9423688; rs41288711; rs34625271; rs34795068; rs35308134; rs34196028; rs33989675; rs12267216; rs11251698; rs35246156; rs3830217; rs11426937; rs10903965; rs5782683; rs35671672; rs10082547; rs9423484; rs12411383; rs2306300; rs11251740; rs9423460; rs35879516; rs2306296; rs9423687; rs34920157; rs11251737; rs7072300; rs34441916; rs7905464; rs12775265; rs11251736; rs34485324; rs12249143; rs35163491; rs3829913; rs35686601; rs11251731; rs9423694; rs35648106; rs3042667; rs11394580; rs28673062; rs12767011; rs12355909; rs7912275; rs11251725; rs5782684; rs12762623; rs34538474; rs7921718; rs28433695; rs35568047; rs12777199; rs35863365; rs12772744; rs34260521; rs6143744; rs12769056; rs2388575; rs12773602; rs7913100; rs11251739; rs2892549; rs35072017; rs11251701; rs11251714; rs4880589; rs34688896; rs35741420; rs11251706; rs35276282; rs11375841; rs11251722; rs2306298; rs12411396; rs12769988; rs35751635; rs34430271; rs12250915; rs35571366; rs35303123; rs41288723; rs2388576; rs7071824; rs4880591; rs34453449; rs41288733; rs5782681; rs9423478; rs11251699; rs7072286; rs6143745; rs34390372; rs9702390; rs12355948; rs34128386; rs34273901; rs7896922; rs7919798; rs7474978; rs35768855; rs12412657; rs11251700; rs11251738; rs7898754; rs7082466; rs7071339; rs10582528; rs34600605; rs7088709; rs35381145; rs7093888; rs5782682; rs11251718; rs10903956; rs2306313; rs12571066; rs35890906; rs9423486; rs6143747; rs6143746; rs10175; rs1043146; rs1043158; rs1043166; rs10508247; rs10736965; rs10751909; rs10794997; rs10794998; rs10795007; rs11251688; rs11251744; rs12678; rs12762013; rs12774814; rs12779561; rs12780595; rs17135477; rs17136264; rs17212411; rs17849904; rs1802344; rs1804254; rs2279216; rs2279217; rs2279218; rs2279219; rs2279220; rs2279221; rs2306319; rs2388558; rs2388559; rs2388560; rs2388561; rs34837384; rs34882494; rs35301243; rs35363509; rs35779348; rs3752802; rs3752803; rs3758630; rs3758631; rs3814586; rs4451611; rs4880594; rs4880595; rs4881107; rs4881109; rs4881110; rs6901; rs7081092; rs7094698; rs7097793; rs7898290; rs7898695; rs7904857; rs7908746; rs7911918; rs7924163; rs9129; rs9423495; rs9423701; rs9423702; rs9423703

# Metabolic_Enzyme_22_General_References:
8117307; 1834056

# Metabolic_Enzyme_22_References:
Not Available

# Metabolic_Enzyme_23_ID:
5565

# Metabolic_Enzyme_23_Name:
GDH/6PGL endoplasmic bifunctional protein precursor [Includes: Glucose 1-dehydrogenase

# Metabolic_Enzyme_23_Synonyms:
Hexose-6-phosphate dehydrogenase; 6- phosphogluconolactonase; 6PGL]

# Metabolic_Enzyme_23_Gene_Name:
H6PD

# Metabolic_Enzyme_23_Protein_Sequence:
>GDH/6PGL endoplasmic bifunctional protein precursor Includes: Glucose 1dehydrogenase
MWNMLIVAMCLALLGCLQAQELQGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGRGHSF
SFHGAALTAPKQGQELMAKALESLSCPKDMAPSHCAEHKDQFLQLSQYRQLKTAEDYQAL
NKDIEAQLQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDH
FSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDGLWNRHHVERVEII
MKETVDAEGRTSFYEEYGVIRDVLQNHLTEVLTLVAMELPHNVSSAEAVLRHKLQVFQAL
RGLQRGSAVVGQYQSYSEQVRRELQKPDSFHSLTPTFAAVLVHIDNLRWEGVPFILMSGK
ALDERVGYARILFKNQACCVQSEKHWAAAQSQCLPRQLVFHIGHGDLGSPAVLVSRNLFR
PSLPSSWKEMEGPPGLRLFGSPLSDYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLL
ASWNFWTPLLESLAHKAPRLYPGGAENGRLLDFEFSSGRLFFSQQQPEQLVPGPGPAPMP
SDFQVLRAKYRESPLVSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQ
QLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHLLQHVRIPYYNIHPMPVHLQQ
RLCAEEDQGAQIYAREISALVANSSFDLVLLGMGADGHTASLFPQSPTGLDGEQLVVLTT
SPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLPHSGQL
VWYMDYDAFLG

# Metabolic_Enzyme_23_Number_of_Residues:
791

# Metabolic_Enzyme_23_Molecular_Weight:
88894

# Metabolic_Enzyme_23_Theoretical_pI:
7.31

# Metabolic_Enzyme_23_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  6-phosphogluconolactonase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  glucose-6-phosphate 1-dehydrogenase activity
 ||
>>>
Process:  glucose catabolism
Process:  pentose-phosphate shunt
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_23_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_23_Specific_Function:
Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates

# Metabolic_Enzyme_23_Pathway:
map00030  Pentose phosphate pathway

# Metabolic_Enzyme_23_Reaction:
6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF02781:G6PD_C;
PF00479:G6PD_N;
PF01182:Glucosamine_iso

# Metabolic_Enzyme_23_Signals:
1-19

# Metabolic_Enzyme_23_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 1.1.1.47;EC 3.1.1.31

# Metabolic_Enzyme_23_GenBank_ID_Protein:
4186038

# Metabolic_Enzyme_23_SwissProt_ID:
G6PE_HUMAN (O95479)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
H6PD

# Metabolic_Enzyme_23_Geneatlas_id:
H6PD

# Metabolic_Enzyme_23_hgnc_id:
HGNC:4795

# Metabolic_Enzyme_23_PDB_ID:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum lumen. Note=Microsomes, endoplasmic reticulum lumen

# Metabolic_Enzyme_23_Gene_Sequence:
>2376 bp
ATGTGGAATATGCTCATAGTGGCGATGTGCTTGGCCCTTCTGGGCTGCCTGCAAGCCCAG
GAGCTCCAGGGACATGTCTCCATAATCCTGCTGGGAGCAACTGGGGACCTGGCTAAGAAG
TACTTATGGCAGGGACTGTTCCAGCTGTACCTGGATGAAGCGGGGAGGGGTCACAGTTTT
AGCTTCCATGGAGCTGCTCTGACAGCCCCCAAGCAGGGTCAAGAGCTCATGGCCAAGGCC
CTGGAATCCCTCTCCTGCCCCAAGGACATGGCACCCAGTCACTGTGCAGAGCACAAGGAT
CAGTTCCTGCAGCTGAGCCAGTACCGCCAACTGAAGACGGCCGAGGACTATCAGGCCCTG
AACAAGGACATCGAGGCACAGCTCCAGCACGCAGGCCTCCGGGAGGCTGGCAGGATCTTC
TACTTCTCAGTGCCACCCTTCGCCTATGAAGACATTGCCCGCAACATCAACAGTAGCTGC
CGGCCAGGCCCGGGCGCCTGGCTGCGGGTTGTCCTTGAGAAACCCTTTGGCCATGACCAC
TTCTCAGCCCAGCAGCTGGCCACAGAACTCGGGACCTTTTTCCAGGAGGAGGAGATGTAC
CGGGTGGACCATTACTTAGGCAAGCAGGCTGTGGCGCAGATCCTGCCTTTCCGAGACCAG
AACCGCAAGGCTTTGGACGGCCTCTGGAACCGGCACCATGTGGAGCGGGTGGAGATCATC
ATGAAAGAGACCGTGGATGCTGAAGGCCGCACCAGCTTCTATGAGGAGTACGGTGTCATT
CGCGACGTCCTCCAGAACCATCTGACGGAGGTCCTCACCCTCGTGGCCATGGAGCTGCCC
CACAATGTCAGCAGTGCGGAGGCTGTGCTGCGGCACAAGCTTCAGGTCTTCCAGGCGCTG
CGGGGCCTGCAGAGGGGCAGTGCCGTCGTGGGCCAGTACCAGTCTTACAGTGAGCAGGTG
CGCAGAGAGCTGCAGAAGCCAGACAGCTTCCACAGCCTGACGCCGACCTTCGCAGGTGTC
CTAGTGCACATTGACAACCTTCGCTGGGAGGGCGTGCCTTTCATCCTGATGTCTGGCAAA
GCCTTGGACGAGAGAGTGGGCTACGCTCGGATCTTGTTCAAGAACCAGGCCTGCTGTGTG
CAGAGCGAAAAGCACTGGGCCGCGGCGCAGAGCCAGTGCCTGCCCCGGCAGCTCGTCTTC
CACATCGGCCATGGCGACCTGGGCAGCCCTGCCGTGCTGGTCAGCAGGAACCTGTTCAGG
CCCTCCCTGCCCTCCAGCTGGAAGGAAATGGAGGGACCACCTGGGCTCCGCCTTTTCGGC
AGCCCTCTGTCCGATTACTACGCCTACAGCCCTGTGCGGGAGCGGGACGCCCACTCCGTC
CTCTTATCCCATATCTTCCATGGCCGGAAGAATTTCTTCATCACCACAGAGAACTTGCTG
GCCTCCTGGAACTTCTGGACCCCTCTGCTGGAGAGCCTGGCCCATAAGGCCCCACGCCTC
TACCCTGGAGGAGCTGAGAATGGCCGTCTGTTGGACTTTGAGTTCAGTAGCGGCCGGTTG
TTCTTTTCCCAGCAGCAGCCGGAGCAGCTGGTGCCAGGGCCAGGGCCGGCCCCAATGCCC
AGTGACTTCCAGGTCCTCAGGGCCAAGTACCGAGAGAGCCCGCTGGTCTCCGCCTGGTCC
GAGGAGCTGATCTCTAAGCTGGCTAATGACATCGAGGCCACCGCTGTGCGAGCCGTGCGG
CGCTTTGGCCAGTTCCACCTGGCACTGTCGGGGGGCTCGAGCCCCGTGGCCCTGTTCCAG
CAGCTGGCCACGGCGCACTATGGCTTCCCCTGGGCCCACACGCACCTGTGGCTGGTTGAC
GAGCGCTGCGTCCCACTCTCAGACCCGGAGTCCAACTTCCAGGGCCTGCAGGCCCACCTG
CTGCAGCACGTCCGGATCCCCTACTACAACATCCACCCCATGCCTGTGCACCTGCAGCAG
CGGCTCTGCGCCGAGGAGGACCAGGGCGCCCAGATCTATGCCAGGGAGATCTCAGCCCTG
GTGGCCAACAGCAGCTTCGACCTGGTGCTGCTGGGCATGGGTGCCGACGGGCACACAGCC
TCCCTCTTCCCACAGTCACCCACTGGCCTGGATGGCGAGCAGCTGGTCGTGCTGACCACG
AGCCCCTCCCAGCCACACCGCCGCATGAGCCTTAGCCTGCCTCTCATCAACCGCGCCAAG
AAGGTGGCAGTCCTGGTCATGGGCAGGATGAAGCGTGAGATCACCACGCTGGTGAGCCGG
GTGGGCCATGAGCCCAAGAAGTGGCCCATCTCGGGTGTCCTGCCGCACTCCGGCCAGCTG
GTGTGGTACATGGACTACGACGCCTTCCTGGGATGA

# Metabolic_Enzyme_23_GenBank_ID_Gene:
AJ012590

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_23_Locus:
1p36

# Metabolic_Enzyme_23_SNPs:
rs6688832; rs17368528; rs35404275; rs34603401; rs35525021; rs7524046; rs9434743; rs9434742; rs11121350; rs35301166; rs1294014; rs11807816; rs2268175; rs12314; rs1294015; rs2239561; rs2268176; rs11121354; rs11121356; rs17368633; rs11121355; rs2268173; rs2071931; rs9434747; rs17033642; rs1142687; rs11121349; rs12405956; rs6685399; rs4908830; rs1294011; rs9434745; rs9435159; rs9434729; rs12126056; rs2268172; rs11588606; rs1142672; rs2239560; rs732950; rs731183; rs3753165; rs1294010; rs3753164; rs2268169; rs3753163; rs2268170; rs6662509; rs11804534; rs763180; rs11809790; rs2310925; rs10864404; rs2311051; rs11806000; rs3765959; rs10864403; rs12082862; rs7526864; rs9435151; rs7514387; rs6577564; rs11801562; rs9434725; rs7522207; rs35610691; rs34274595; rs12118991; rs35668164; rs17368556; rs35511555; rs34580447; rs35863691; rs7412488; rs36094664; rs34082738; rs34448374; rs36058755; rs3207298; rs33954071; rs3207317; rs3752547; rs5772361; rs41280760; rs9434726; rs35833857; rs12728837; rs4908831; rs1065216; rs3207316; rs3057978; rs11588618; rs35071335; rs41280764; rs9435162; rs2268174; rs9435144; rs35341128; rs34967254; rs9435148; rs34715803; rs1142686; rs1142671; rs9435161; rs1138467; rs12144045; rs34078161; rs12403063; rs1138468; rs1142675; rs35486518; rs3206225; rs1142689; rs9435163; rs6697931; rs1294016; rs35600947; rs9434746; rs41280762; rs2268171; rs6658895; rs12040818; rs1142688; rs9435164; rs1142690; rs34854341; rs9434737; rs36065021; rs1294009; rs5772359; rs12039626; rs9435158; rs1890684; rs34931714; rs12076525; rs2097519; rs763179; rs28548609; rs28665681; rs34308839; rs12083129; rs10449320; rs3861753; rs9434736; rs12032814; rs11805951; rs9435152; rs34764359; rs28496367; rs35492379; rs9435156; rs9434732; rs11804519; rs3765958; rs5772358; rs9435155; rs12042692; rs9434738; rs743972; rs35063052; rs12039625; rs2185298; rs12738271; rs2095907; rs4601607; rs34149245; rs6680990; rs9435167; rs9435166; rs7523498; rs35587892; rs7523400; rs1003369; rs1004920; rs10489436; rs10746487; rs11590326; rs12072683; rs12093524; rs12093571; rs12403829; rs1294012; rs2097520; rs2105225; rs2871656; rs34870859; rs3753271; rs4908832; rs6688233; rs7517538; rs916379; rs916380; rs916381; rs916382; rs916383; rs916384; rs916385; rs916386; rs9434723; rs9435168; rs9435179; rs946599; rs946602

# Metabolic_Enzyme_23_General_References:
10349511

# Metabolic_Enzyme_23_References:
8813710

# Metabolic_Enzyme_24_ID:
6117

# Metabolic_Enzyme_24_Name:
Glycerol kinase

# Metabolic_Enzyme_24_Synonyms:
ATP:glycerol 3-phosphotransferase; Glycerokinase; GK

# Metabolic_Enzyme_24_Gene_Name:
GK

# Metabolic_Enzyme_24_Protein_Sequence:
>Glycerol kinase
MAASKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEI
LHSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKITGEPLYNAVVWLDLRTQ
STVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEKRALFGTIDS
WLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKQLCEFFGIPMEILPNVRSSSEIY
GLMKAGALEGVPISGCLGDQSAALVGQMCFQIGQAKNTYGTGCFLLCNTGHKCVFSDHGL
LTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKTSEEIEKLAKEVGTSYGCYF
VPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLS
HLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLS
AVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSPESGIP

# Metabolic_Enzyme_24_Number_of_Residues:
524

# Metabolic_Enzyme_24_Molecular_Weight:
57490

# Metabolic_Enzyme_24_Theoretical_pI:
6.25

# Metabolic_Enzyme_24_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  glycerol kinase activity
 ||
>>>
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  polyol metabolism
Process:  glycerol metabolism
Process:  glycerol-3-phosphate metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_24_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_24_Specific_Function:
Key enzyme in the regulation of glycerol uptake and metabolism

# Metabolic_Enzyme_24_Pathway:
map00561  Glycerolipid metabolism

# Metabolic_Enzyme_24_Reaction:
ATP + glycerol = ADP + sn-glycerol 3-phosphate

# Metabolic_Enzyme_24_Pfam_Domain_Function:
PF02782:FGGY_C;
PF00370:FGGY_N

# Metabolic_Enzyme_24_Signals:
None

# Metabolic_Enzyme_24_Transmembrane_Regions:
None

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 2.7.1.30

# Metabolic_Enzyme_24_GenBank_ID_Protein:
348167

# Metabolic_Enzyme_24_SwissProt_ID:
GLPK_HUMAN (P32189)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
GK

# Metabolic_Enzyme_24_Geneatlas_id:
GK

# Metabolic_Enzyme_24_hgnc_id:
HGNC:4289

# Metabolic_Enzyme_24_PDB_ID:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; peripheral membrane protein; cytoplasmic side. Cytoplasm. Note=In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm

# Metabolic_Enzyme_24_Gene_Sequence:
>1575 bp
ATGGCAGCCTCAAAGAAGGCAGTTTTGGGGCCATTGGTGGGGGCGGTGGACCAGGGCACC
AGTTCGACGCGCTTTTTGGTTTTCAATTCAAAAACAGCTGAACTACTTAGTCATCATCAA
GTAGAAATAAAACAAGAGTTCCCAAGAGAAGGATGGGTGGAACAGGACCCTAAGGAAATT
CTACATTCTGTCTATGAGTGTATAGAGAAAACATGTGAGAAACTTGGACAGCTCAATATT
GATATTTCCAACATAAAAGCTATTGGTGTCAGCAACCAGAGGGAAACCACTGTAGTCTGG
GACAAGATAACTGGAGAGCCTCTCTACAATGCTGTGGTGTGGCTTGATCTAAGAACCCAG
TCTACCGTTGAGAGTCTTAGTAAAAGAATTCCAGGAAATAATAACTTTGTCAAGTCCAAG
ACAGGCCTTCCACTTAGCACTTACTTCAGTGCAGTGAAACTTCGTTGGCTCCTTGACAAT
GTGAGAAAAGTTCAAAAGGCCGTTGAAGAAAAACGAGCTCTTTTTGGGACTATTGATTCA
TGGCTTATTTGGAGTTTGACAGGAGGAGTCAATGGAGGTGTCCACTGTACAGATGTAACA
AATGCAAGTAGGACTATGCTTTTCAACATTCATTCTTTGGAATGGGATAAACAACTCTGC
GAATTTTTTGGAATTCCAATGGAAATTCTTCCAAATGTCCGGAGTTCTTCTGAGATCTAT
GGCCTAATGAAAGCTGGGGCCTTGGAAGGTGTGCCAATATCTGGGTGTTTAGGGGACCAG
TCTGCTGCATTGGTGGGACAAATGTGCTTCCAGATTGGACAAGCCAAAAATACGTATGGA
ACAGGATGTTTCTTACTATGTAATACAGGCCATAAGTGTGTATTTTCTGATCATGGCCTT
CTCACCACAGTGGCTTACAAACTTGGCAGAGACAAACCAGTATATTATGCTTTGGAAGGT
TCTGTAGCTATAGCTGGTGCTGTTATTCGCTGGCTAAGAGACAATCTTGGAATTATAAAG
ACCTCAGAAGAAATTGAAAAACTTGCTAAAGAAGTAGGTACTTCTTATGGCTGCTACTTC
GTCCCAGCATTTTCGGGGTTATATGCACCTTATTGGGAGCCCAGCGCAAGAGGGATAATC
TGTGGACTCACTCAGTTCACCAATAAATGCCATATTGCTTTTGCTGCATTAGAAGCTGTT
TGTTTCCAAACTCGAGAGATTTTGGATGCCATGAATCGAGACTGTGGAATTCCACTCAGT
CATTTGCAGGTAGATGGAGGAATGACCAGCAACAAAATTCTTATGCAGCTACAAGCAGAC
ATTCTGTATATACCAGTAGTGAAGCCCTCAATGCCCGAAACCACTGCACTGGGTGCGGCT
ATGGCGGCAGGGGCTGCAGAAGGAGTCGGCGTATGGAGTCTCGAACCCGAGGATTTGTCT
GCCGTCACGATGGAGCGGTTTGAACCTCAGATTAATGCGGAGGAAAGTGAAATTCGTTAT
TCTACATGGAAGAAAGCTGTGATGAAGTCAATGGGTTGGGTTACAACTCAATCTCCAGAA
AGTGGTATTCCATAA

# Metabolic_Enzyme_24_GenBank_ID_Gene:
L13943

# Metabolic_Enzyme_24_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_24_Locus:
Xp21.3

# Metabolic_Enzyme_24_SNPs:
rs17854202; rs34795481; rs5926945; rs1803659; rs5972222; rs931240; rs5927582; rs6527003; rs619; rs728149; rs4636357; rs12844553; rs4487947; rs6527002; rs5972211; rs5927593; rs1482834; rs6526991; rs5927587; rs6526997; rs5927596; rs5927584; rs4077820; rs12843585; rs967785; rs5927589; rs5972207; rs4609338; rs12560212; rs6526996; rs5926944; rs5927595; rs2868571; rs5926942; rs5972213; rs2035432; rs620; rs12854653; rs12011728; rs16989176; rs1871965; rs7058925; rs7878037; rs5927585; rs16989169; rs5927594; rs6526995; rs5972206; rs6631156; rs12010068; rs4617310; rs12007993; rs5972204; rs5971513; rs12851094; rs5972202; rs7879845; rs2035431; rs4345726; rs5972203; rs12557274; rs5927588; rs12009986; rs5927590; rs5926943; rs5927581; rs5927599; rs2170611; rs11095189; rs17854203; rs17857267; rs5927597; rs5972217; rs5972215; rs5927598; rs5972216; rs5926946; rs3931219; rs5972219; rs34867477; rs5972221; rs5972220; rs5972218; rs41302637; rs34792758; rs35918035; rs35586363; rs36091656; rs41305205; rs34365099; rs10644351; rs4829198; rs5971511; rs34992170; rs41311819; rs34773549; rs6631159; rs35313243; rs34172820; rs35124133; rs6631151; rs10682299; rs6631142; rs34474761; rs35688593; rs35784640; rs5927591; rs35182768; rs5927580; rs28366724; rs35849427; rs34275810; rs12847609; rs6631141; rs6628544; rs5971512; rs35027105; rs5927586; rs6631158; rs5926938; rs35498618; rs35856351; rs5926941; rs6631155; rs10656820; rs35354095; rs35120364; rs5927592; rs35987506; rs35931680; rs4415475; rs11281728; rs5926940; rs11306027; rs6631140; rs34129824; rs35468110; rs12007023; rs28697906; rs6631157; rs6631144; rs35791116; rs5972209; rs28390198; rs41309689; rs34160985; rs5926939; rs35547075; rs3838210; rs41311491; rs12843247; rs12845821; rs35183149; rs35290317; rs12007026; rs3747459; rs5972210; rs5972205; rs11282593; rs6631143; rs11349869; rs36091714; rs34474103; rs6631161; rs34088900; rs12007087; rs6631146; rs11417266; rs35182714; rs12862589; rs34301411; rs36133772; rs12844258; rs11461651; rs12011679; rs4486355; rs6631150; rs11400828; rs34773915; rs3838209; rs34462788; rs12007053; rs2868570; rs5927606; rs5927607; rs5972224; rs6526989; rs6527012; rs6653843; rs7049882

# Metabolic_Enzyme_24_General_References:
8401584; 7987308; 8499912; 8499898; 8651297; 9719371; 10736265

# Metabolic_Enzyme_24_References:
11410857; 2127799; 2545516; 2982325

# Metabolic_Enzyme_25_ID:
6880

# Metabolic_Enzyme_25_Name:
Triosephosphate isomerase

# Metabolic_Enzyme_25_Synonyms:
TIM; Triose-phosphate isomerase

# Metabolic_Enzyme_25_Gene_Name:
TPI1

# Metabolic_Enzyme_25_Protein_Sequence:
>Triosephosphate isomerase
MAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKI
AVAAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAE
GLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQ
QAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPE
FVDIINAKQ

# Metabolic_Enzyme_25_Number_of_Residues:
249

# Metabolic_Enzyme_25_Molecular_Weight:
26670

# Metabolic_Enzyme_25_Theoretical_pI:
6.91

# Metabolic_Enzyme_25_GO_Classification:
>>>
Function:  catalytic activity
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, interconverting aldoses and ketoses
Function:  triose-phosphate isomerase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_25_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_25_Specific_Function:
D-glyceraldehyde 3-phosphate = glycerone phosphate

# Metabolic_Enzyme_25_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00031  Inositol metabolism;
 map00051  Fructose and mannose metabolism;
 map00710  Carbon fixation

# Metabolic_Enzyme_25_Reaction:
D-glyceraldehyde 3-phosphate = glycerone phosphate

# Metabolic_Enzyme_25_Pfam_Domain_Function:
PF00121:TIM

# Metabolic_Enzyme_25_Signals:
None

# Metabolic_Enzyme_25_Transmembrane_Regions:
None

# Metabolic_Enzyme_25_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_25_EC_Link:
EC 5.3.1.1

# Metabolic_Enzyme_25_GenBank_ID_Protein:
339841

# Metabolic_Enzyme_25_SwissProt_ID:
TPIS_HUMAN (P60174)

# Metabolic_Enzyme_25_swissprot_Name:
Not Available

# Metabolic_Enzyme_25_Genecard_id:
TPI1

# Metabolic_Enzyme_25_Geneatlas_id:
TPI1

# Metabolic_Enzyme_25_hgnc_id:
HGNC:12009

# Metabolic_Enzyme_25_PDB_ID:
1HTI

# Metabolic_Enzyme_25_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_25_Subcellular_Location:
Not Available

# Metabolic_Enzyme_25_Gene_Sequence:
>750 bp
ATGGCGCCCTCCAGGAAGTTCTTCGTTGGGGGAAACTGGAAGATGAACGGGCGGAAGCAG
AGTCTGGGGGAGCTCATCGGCACTCTGAACGCGGCCAAGGTGCCGGCCGACACCGAGGTG
GTTTGTGCTCCCCCTACTGCCTATATCGACTTCGCCCGGCAGAAGCTAGATCCCAAGATT
GCTGTGGCTGCGCAGAACTGCTACAAAGTGACTAATGGGGCTTTTACTGGGGAGATCAGC
CCTGGCATGATCAAAGACTGCGGAGCCACGTGGGTGGTCCTGGGACACTCAGAGAGAAGG
CATGTCTTTGGGGAGTCAGATGAGCTGATTGGGCAGAAAGTGGCCCATGCTCTGGCAGAG
GGACTCGGAGTAATCGCCTGCATTGGGGAGAAGCTAGATGAAAGGGAAGCTGGCATCACT
GAGAAGGTTGTTTTCGAGCAGACAAAGGTCATCGCAGATAACGTGAAGGACTGGAGCAAG
GTCGTCCTCGCCTATGAGCCTGTGTGGGCCATTGGTACTGGCAAGACTGCAACACCCCAA
CAGGCCCAGGAAGTACACGAGAAGCTCCGAGGATGGCTGAAGTCCAACGTCTCTGATGCG
GTGGCTCAGAGCACCCGTATCATTTATGGAGGCTCTGTGACTGGGGCAACCTGCAAGGAG
CTGGCCAGCCAGCCTGATGTGGATGGCTTCCTTGTGGGTGGTGCTTCCCTCAAGCCCGAA
TTCGTGGACATCATCAATGCCAAACAATGA

# Metabolic_Enzyme_25_GenBank_ID_Gene:
M10036

# Metabolic_Enzyme_25_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_25_Locus:
12p13

# Metabolic_Enzyme_25_SNPs:
rs2071067; rs2001004; rs2071066; rs2071069; rs2001005; rs12302749; rs3174612; rs17851580; rs11548739; rs11548737; rs12692; rs11064434; rs2071068; rs7977645; rs11447131; rs2071065; rs1800200; rs1800201; rs1800202; rs1055060; rs11064432; rs11064436; rs11064437; rs11064438; rs11608936; rs11612543; rs11830318; rs11832671; rs12824102; rs17790720; rs1802898; rs2071059; rs2071064; rs3178452; rs3182461; rs3213432; rs35165406; rs35535772; rs35909908; rs3825335; rs4334119; rs6489739; rs7136152; rs7300411

# Metabolic_Enzyme_25_General_References:
6434534; 2579079; 4022011; 8723724; 9074930; 9150946; 9150948; 2925688; 8061610; 2876430; 1339398; 8503454; 8571957; 9338582

# Metabolic_Enzyme_25_References:
4655425

# Metabolic_Enzyme_26_ID:
6140

# Metabolic_Enzyme_26_Name:
NADP-dependent malic enzyme, mitochondrial precursor

# Metabolic_Enzyme_26_Synonyms:
NADP-ME; Malic enzyme 3

# Metabolic_Enzyme_26_Gene_Name:
ME3

# Metabolic_Enzyme_26_Protein_Sequence:
>NADPdependent malic enzyme, mitochondrial precursor
MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLN
KGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKL
FYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNI
KAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRD
PLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCM
FNDDIQGTASVAVAGILAALRITNNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKA
EATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGA
FTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGK
TFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLST
IRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMN
VQTV

# Metabolic_Enzyme_26_Number_of_Residues:
604

# Metabolic_Enzyme_26_Molecular_Weight:
67055

# Metabolic_Enzyme_26_Theoretical_pI:
7.92

# Metabolic_Enzyme_26_GO_Classification:
>>>
Function:  malate dehydrogenase activity
Function:  malic enzyme activity
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  malate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_26_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_26_Specific_Function:
(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH

# Metabolic_Enzyme_26_Pathway:
map00620  Pyruvate metabolism;
 map00710  Carbon fixation

# Metabolic_Enzyme_26_Reaction:
(S)-malate + NADP+ = pyruvate + CO2 + NADPH

# Metabolic_Enzyme_26_Pfam_Domain_Function:
PF00390:malic;
PF03949:Malic_M

# Metabolic_Enzyme_26_Signals:
None

# Metabolic_Enzyme_26_Transmembrane_Regions:
None

# Metabolic_Enzyme_26_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_26_EC_Link:
EC 1.1.1.40

# Metabolic_Enzyme_26_GenBank_ID_Protein:
535012

# Metabolic_Enzyme_26_SwissProt_ID:
MAON_HUMAN (Q16798)

# Metabolic_Enzyme_26_swissprot_Name:
Not Available

# Metabolic_Enzyme_26_Genecard_id:
ME3

# Metabolic_Enzyme_26_Geneatlas_id:
ME3

# Metabolic_Enzyme_26_hgnc_id:
HGNC:6985

# Metabolic_Enzyme_26_PDB_ID:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_26_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_26_Gene_Sequence:
>1815 bp
ATGGGTGCCGCGCTGGGGACAGGCACGCGGCTGGCTCCCTGGCCGGGCCGGGCCTGCGGC
GCCCTCCCGCGCTGGACACCCACCGCGCCCGCCCAAGGCTGCCACTCCAAGCCTGGCCCG
GCGCGCCCTGTGCCCCTGAAGAAGCGCGGATACGATGTCACCAGGAACCCTCATCTCAAC
AAGGGGATGGCCTTTACCCTTGAAGAAAGGCTGCAGCTTGGAATCCACGGCCTAATCCCG
CCCTGCTTTCTGAGCCAGGACGTCCAGCTCCTCCGAATCATGAGATATTACGAGCGGCAG
CAGAGTGACCTGGACAAGTACATCATTCTCATGACACTCCAAGACCGGAACGAGAAGCTC
TTCTACCGAGTGCTGACTTCGGATGTGGAGAAGTTCATGCCAATCGTGTACACGCCTACC
GTGGGGCTGGCCTGTCAGCACTATGGCCTGACTTTCCGCAGGCCCCGTGGACTGTTCATC
ACCATTCATGACAAAGGTCATCTTGCAACAATGCTGAATTCTTGGCCAGAAGACAATATT
AAGGCCGTGGTGGTGACTGATGGGGAGCGCATCCTGGGCCTGGGAGACCTGGGCTGCTAC
GGCATGGGCATCCCTGTGGGCAAGCTGGCCCTGTACACGGCATGCGGAGGGGTGAACCCG
CAGCAGTGCCTCCCTGTGCTGCTGGACGTCGGCACCAACAATGAGGAGCTGCTCAGAGAC
CCTCTGTACATCGGCCTGAAACACCAGCGCGTGCACGGGAAGGCATACGATGACTTGCTG
GATGAGTTCATGCAGGCTGTGACAGACAAGTTTGGAATAAATTGCCTCATCCAATTTGAA
GACTTCGCCAATGCCAATGCCTTCCGCCTGCTCAACAAATACCGTAACAAGTACTGCATG
TTCAATGATGACATCCAAGGCACAGCCTCCGTTGCTGTGGCAGGGATCTTGGCTGCTCTG
CGAATCACCAACAACAAGCTTTCCAATCACGTGTTTGTTTTCCAAGGTGCAGGCGAGGCA
GCTATGGGCATTGCCCACCTCCTTGTCATGGCCCTAGAGAAAGAAGGTGTACCGAAGGCA
GAGGCCACAAGAAAGATCTGGATGGTGGACTCTAAAGGGCTCATTGTCAAGGGGAGGAGC
CACCTGAACCATGAAAAGGAGATGTTTGCCCAAGACCATCCTGAAGTCAACTCCCTGGAG
GAGGTGGTGAGGCTGGTGAAGCCCACAGCCATCATAGGTGTTGCTGCCATCGCAGGAGCC
TTCACGGAGCAGATTCTGAGGGACATGGCCTCCTTCCACGAGCGCCCTATCATCTTTGCC
CTGAGCAACCCCACCAGCAAGGCCGAGTGCACGGCTGAGAAGTGCTACCGGGTCACCGAG
GGCCGAGGGATTTTTGCCAGTGGAAGTCCTTTTAAGAGTGTGACTCTGGAAGATGGCAAG
ACCTTCATTCCTGGGCAGGGAAACAATGCTTACGTGTTCCCCGGGGTGGCACTGGGAGTC
ATCGCCGGCGGGATCCGGCACATCCCAGATGAGATCTTCCTCCTGACAGCAGAGCAAATT
GCCCAGGAAGTCTCTGAGCAGCATCTGTCCCAGGGGAGACTCTATCCACCACTCAGCACC
ATCCGAGACGTGTCTTTGAGAATTGCCATCAAAGTTCTCGACTACGCGTACAAACACAAC
CTGGCTTCCTACTACCCAGAGCCTAAGGACAAGGAGGCTTTTGTAAGATCCCTGGTCTAC
ACTCCAGACTATGACTCCTTTACACTGGACAGCTACACTTGGCCCAAGGAAGCCATGAAT
GTTCAGACGGTCTGA

# Metabolic_Enzyme_26_GenBank_ID_Gene:
X79440

# Metabolic_Enzyme_26_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_26_Locus:
11cen-q22.3

# Metabolic_Enzyme_26_SNPs:
rs1042780; rs4943943; rs17211115; rs7946487; rs12287767; rs34662182; rs2446230; rs1945034; rs632873; rs1541310; rs675775; rs677643; rs1541309; rs722158; rs1540082; rs1938921; rs1945142; rs659405; rs2051434; rs624183; rs553351; rs666472; rs587362; rs498981; rs1894012; rs618513; rs539805; rs1938935; rs2226566; rs663262; rs660372; rs679220; rs1938924; rs623478; rs525764; rs632538; rs2511090; rs681333; rs647561; rs658166; rs643414; rs609848; rs2156532; rs634509; rs1458382; rs999472; rs2078385; rs2446228; rs668753; rs601646; rs949349; rs1938931; rs582282; rs1938938; rs651089; rs1945036; rs611156; rs2032356; rs722157; rs622933; rs1938923; rs1938926; rs661163; rs601824; rs616018; rs679076; rs633708; rs538058; rs1841066; rs539939; rs590401; rs4319536; rs4944580; rs7123773; rs655934; rs7950878; rs3819227; rs10219305; rs10898524; rs7109270; rs10219173; rs3824954; rs672526; rs10898501; rs651758; rs609885; rs502749; rs949351; rs7948981; rs10792860; rs7120052; rs1945143; rs7120444; rs7940192; rs4944602; rs4439535; rs7951868; rs6592301; rs10898498; rs626049; rs2279046; rs7112309; rs4144867; rs625925; rs687804; rs493010; rs7122296; rs11607733; rs7940187; rs2446229; rs4944612; rs10898483; rs10898514; rs11234656; rs1945043; rs4944607; rs12285249; rs606546; rs601988; rs1542426; rs585218; rs7117375; rs10444375; rs1938928; rs4943949; rs2051433; rs6592296; rs4405344; rs6592295; rs10792865; rs10792866; rs7103271; rs11234707; rs7941337; rs2446225; rs658324; rs10219319; rs7937853; rs7109521; rs7105863; rs4944613; rs630438; rs7122406; rs4144866; rs2242142; rs7943741; rs1938927; rs10792861; rs638041; rs7940549; rs624843; rs7940654; rs7117234; rs7122928; rs12282010; rs7940523; rs10501627; rs10898484; rs4944596; rs7122479; rs7108055; rs669325; rs7941446; rs4382935; rs7949910; rs12417575; rs7108746; rs4944604; rs12361283; rs4592448; rs7925862; rs662361; rs588287; rs1540083; rs668272; rs6592294; rs4944609; rs7103017; rs611730; rs507123; rs7109853; rs1945145; rs7127944; rs636485; rs1006586; rs677700; rs9787905; rs7122239; rs4944592; rs585749; rs603241; rs1938929; rs2125363; rs601300; rs7106865; rs1458384; rs147045; rs949350; rs4382934; rs7935611; rs1938932; rs4944611; rs4144865; rs630454; rs10501625; rs2511082; rs1945146; rs657378; rs584953; rs7119775; rs605251; rs7116278; rs3758877; rs10898490; rs616794; rs12284853; rs1379872; rs12576144; rs10792854; rs7951185; rs4944593; rs1563682; rs7940587; rs676106; rs10898512; rs10792858; rs12575285; rs7940772; rs579719; rs11819827; rs612163; rs507211; rs7940781; rs11828425; rs12290684; rs6592297; rs10501621; rs7938505; rs659301; rs4245422; rs10792864; rs2168862; rs11825033; rs7117702; rs621653; rs7126717; rs503583; rs10219378; rs4245423; rs10501624; rs17149147; rs11606017; rs3781812; rs7937668; rs638492; rs11234691; rs4944600; rs672266; rs646691; rs613412; rs11826066; rs661328; rs631082; rs7115580; rs10898488; rs598187; rs635934; rs679382; rs10792857; rs4405345; rs10501620; rs10501628; rs628406; rs7930619; rs2279047; rs1945144; rs7118187; rs17819683; rs668270; rs597793; rs7944874; rs17149169; rs4944603; rs10444372; rs635637; rs12797615; rs683899; rs4245420; rs3781813; rs663208; rs647782; rs6592302; rs12804997; rs661954; rs10792856; rs10898515; rs10501623; rs7123010; rs4943945; rs7103556; rs591060; rs653715; rs4245418; rs7934133; rs17211577; rs7125366; rs11234702; rs17211570; rs2155035; rs610790; rs7126810; rs4944614; rs17149234; rs12289252; rs7130920; rs2840368; rs1006587; rs12420965; rs4245424; rs608180; rs561363; rs17819176; rs7940788; rs640310; rs1870323; rs2125362; rs11234662; rs4944610; rs10792855; rs679977; rs10501622; rs585527; rs597296; rs7940590; rs664613; rs7928552; rs10898500; rs593853; rs11821546; rs11234708; rs10792862; rs17149180; rs614995; rs11234719; rs17819523; rs767776; rs1458381; rs4944581; rs2279048; rs7102806; rs2446224; rs583594; rs10898496; rs10898516; rs10501626; rs4245421; rs624236; rs7115834; rs641541; rs10898485; rs10400291; rs10792863; rs17159928; rs11234658; rs7107136; rs1938922; rs7123044; rs12285344; rs677301; rs7941124; rs4245419; rs4944586; rs12281596; rs624870; rs7940448; rs9705039; rs1938925; rs12293809; rs17757676; rs2446226; rs11234676; rs7121583; rs11606042; rs9667152; rs2032355; rs9704409; rs11234731; rs589368; rs10898499; rs11234700; rs7930715; rs687138; rs3889658; rs628449; rs7925379; rs7924879; rs7103642; rs12801189; rs637693; rs12365092; rs531908; rs7949920; rs11234657; rs17818784; rs11234711; rs10898517; rs11234716; rs17211409; rs11234678; rs10444374; rs9645702; rs7128131; rs7116895; rs12798729; rs10898494; rs7130902; rs10898505; rs674250; rs11234683; rs17149242; rs12805940; rs4944616; rs11234729; rs11604162; rs11820663; rs10898507; rs642780; rs7941051; rs619195; rs535652; rs668984; rs11234704; rs7945440; rs969034; rs12291729; rs589174; rs681158; rs11234692; rs12419111; rs2125358; rs3824952; rs12573953; rs7480835; rs12365653; rs566633; rs7125970; rs10898508; rs12269800; rs4245417; rs648798; rs7108710; rs9667168; rs1938918; rs4944585; rs1824279; rs1945139; rs12792674; rs748102; rs12793144; rs12421147; rs7944836; rs590750; rs501362; rs7938344; rs11821635; rs674481; rs10444371; rs12419781; rs17211458; rs12574128; rs4944617; rs643950; rs10792871; rs7104141; rs12283397; rs11234665; rs4944595; rs9943610; rs12285306; rs7945240; rs7938901; rs11234701; rs4943946; rs7952019; rs10898513; rs9645703; rs1945138; rs17211053; rs7943403; rs2155033; rs2212341; rs7938741; rs11828773; rs17818845; rs682501; rs12808738; rs11602862; rs627684; rs4944594; rs12799562; rs1458383; rs11234715; rs9667489; rs10898502; rs1541308; rs1540081; rs12793707; rs7941576; rs10898518; rs2276394; rs511884; rs7926965; rs12364541; rs10898509; rs11234713; rs9667156; rs11234705; rs530278; rs4944587; rs644086; rs11234690; rs11234718; rs1350478; rs539214; rs4944582; rs12277137; rs11606745; rs2212340; rs12222139; rs673118; rs7945260; rs3824953; rs688079; rs12361416; rs12362293; rs661115; rs7948764; rs17149223; rs12420485; rs11234727; rs11234689; rs9943508; rs12804208; rs7935437; rs10898495; rs584068; rs503195; rs4944583; rs7927467; rs593450; rs12224723; rs17149245; rs10898510; rs2511083; rs11607554; rs594106; rs1938920; rs9667775; rs12797575; rs7930401; rs546427; rs4291698; rs11234686; rs12790474; rs4391846; rs11234699; rs1945137; rs10898503; rs11234714; rs7940800; rs12799435; rs7119485; rs4943955; rs12285279; rs2017483; rs7117143; rs12793198; rs7946685; rs7109555; rs7927796; rs11234726; rs998872; rs2446227; rs638135; rs17149197; rs12792300; rs670602; rs596056; rs7930654; rs3758878; rs480290; rs12226269; rs4944597; rs610476; rs2511081; rs751911; rs1938919; rs4944622; rs12288119; rs11602628; rs12280733; rs11234712; rs1945141; rs10898506; rs660893; rs9943611; rs17211563; rs7105382; rs12269985; rs17211584; rs605618; rs10792868; rs694952; rs12575580; rs17149130; rs17149226; rs1945035; rs610842; rs10898493; rs10898504; rs582976; rs7927795; rs12274942; rs17149238; rs10898511; rs653313; rs4943948; rs670736; rs1452138; rs684365; rs1452137; rs1452136; rs4943940; rs589887; rs12283035; rs4944578; rs11823255; rs12294756; rs682915; rs547591; rs7926796; rs12281645; rs10898525; rs35245729; rs3182235; rs15926; rs17852036; rs17845700; rs17856661; rs11556735; rs35059554; rs1062639; rs987649; rs685439; rs656307; rs5793201; rs646798; rs7924919; rs34470258; rs693052; rs12574675; rs7939530; rs11355612; rs11234687; rs34652301; rs618843; rs28895937; rs11518769; rs515798; rs3781806; rs12271274; rs11234668; rs36139518; rs11234673; rs9667498; rs12294332; rs2511089; rs623785; rs4483612; rs654286; rs496167; rs3862787; rs1902958; rs672264; rs34131458; rs12805450; rs582886; rs34631227; rs661972; rs7124538; rs35941464; rs11559614; rs1791443; rs11234709; rs10618233; rs7118346; rs12273697; rs9735826; rs34382146; rs10559080; rs12271571; rs659700; rs34909419; rs11234697; rs34838255; rs11383258; rs672280; rs10545624; rs680846; rs35804280; rs11459186; rs11234720; rs11359686; rs35420773; rs661083; rs4500512; rs12283825; rs28837406; rs34095490; rs12795419; rs618384; rs605255; rs11276982; rs4944620; rs28804208; rs10652368; rs1619882; rs34416639; rs2125360; rs2510498; rs35621612; rs34691357; rs4943952; rs34939684; rs7122008; rs11821842; rs12282012; rs12575681; rs12787395; rs11308452; rs11535845; rs11602146; rs7122667; rs34300602; rs35429348; rs658509; rs550761; rs34659727; rs35175493; rs35291772; rs12794991; rs597823; rs34754668; rs5793204; rs591474; rs10636674; rs657580; rs12362471; rs34832707; rs34557852; rs34946099; rs35892534; rs12294331; rs28603177; rs34313794; rs2219430; rs7934775; rs35187445; rs11234669; rs7929523; rs5793202; rs11601960; rs615371; rs34220027; rs34900435; rs34557683; rs2446231; rs11494278; rs11512936; rs35947577; rs3837399; rs9634021; rs3894263; rs11387187; rs10569902; rs6144422; rs12575999; rs5793205; rs12279297; rs11234664; rs12271552; rs28799720; rs4944590; rs34027067; rs35731805; rs11234696; rs35019870; rs602923; rs686768; rs643072; rs9667181; rs28678569; rs11369958; rs663543; rs12785372; rs4944588; rs11366218; rs2156531; rs11234660; rs12271548; rs34265019; rs604299; rs36152939; rs34764333; rs34278824; rs11392522; rs504635; rs12788873; rs17149146; rs2511085; rs4944579; rs34725712; rs11234721; rs35651342; rs642278; rs663073; rs11560984; rs12292032; rs7103785; rs12788651; rs1938934; rs28446263; rs35122148; rs11828585; rs10676754; rs11271121; rs2852378; rs34224480; rs683408; rs595031; rs11234677; rs617962; rs35557705; rs12269737; rs35393888; rs12417744; rs4943942; rs28825102; rs12804283; rs12804130; rs10672954; rs9705154; rs670825; rs12280101; rs35129724; rs12146569; rs28494065; rs4462374; rs35905440; rs471780; rs11512882; rs12271549; rs11532101; rs7115594; rs11530882; rs4944601; rs2511084; rs11234661; rs2305928; rs35463445; rs635971; rs36152806; rs7107161; rs34988004; rs34080694; rs34877706; rs35748086; rs36124549; rs12280500; rs34887500; rs34028266; rs5793206; rs2226858; rs34061130; rs12222903; rs34405620; rs3045014; rs35163253; rs12805420; rs1235409; rs35546812; rs7939052; rs11530863; rs12293152; rs11302044; rs12794525; rs604128; rs10601910; rs12804026; rs34349106; rs503155; rs34258229; rs653779; rs11512938; rs11234666; rs34699198; rs12291889; rs12362900; rs11234733; rs687669; rs28609643; rs10698015; rs12806468; rs10579155; rs642728; rs7112251; rs28583010; rs4943954; rs11533267; rs12791972; rs28716504; rs35269702; rs35968408; rs10653582; rs34393952; rs11501849; rs11234670; rs34996965; rs11234722; rs596322; rs10652369; rs5793209; rs7102548; rs487960; rs4944618; rs689039; rs34103747; rs12792567; rs34573490; rs12278573; rs35677637; rs34782520; rs12786394; rs10659565; rs34796489; rs4943941; rs35635737; rs12787475; rs10579052; rs35359440; rs627383; rs5793198; rs35222052; rs34315700; rs28452300; rs609855; rs11512934; rs4122041; rs503923; rs581796; rs11561000; rs629038; rs11234685; rs2511086; rs35870909; rs2105784; rs752519; rs12288171; rs679731; rs659781; rs33973657; rs4943950; rs35899335; rs12803885; rs12276356; rs10538002; rs34930310; rs11530862; rs12804089; rs7117530; rs2276393; rs1007948; rs3781808; rs34514194; rs36071853; rs34544991; rs10675389; rs12280100; rs10444373; rs12291626; rs35352939; rs582638; rs11603205; rs661831; rs11234706; rs10559079; rs4471455; rs34334006; rs1060779; rs35625263; rs503949; rs28865371; rs28850038; rs11234667; rs4614483; rs36030892; rs36014844; rs747227; rs11388635; rs28605742; rs35377581; rs7115713; rs619472; rs7124121; rs36012184; rs35255565; rs34698065; rs35650693; rs11234672; rs12805421; rs620054; rs11518768; rs11824279; rs11442101; rs35831878; rs35439198; rs28824521; rs35676005; rs11234730; rs4553393; rs12280255; rs11518770; rs648726; rs5793200; rs5793207; rs12804407; rs35754183; rs34677719; rs34493285; rs619829; rs11234671; rs11501724; rs883190; rs688119; rs648258; rs663627; rs12417361; rs11234717; rs7484000; rs11234688; rs12272130; rs28803287; rs35723009; rs35942916; rs3216158; rs12805438; rs35042210; rs7111906; rs11537258; rs2511080; rs10539253; rs35030247; rs11501841; rs4291697; rs35061999; rs5793199; rs603890; rs1612079; rs35686713; rs35722020; rs35636838; rs12805566; rs10160338; rs11234684; rs35072041; rs34920485; rs2125361; rs11234698; rs1938937; rs509870; rs35086246; rs34385651; rs34267395; rs11305226; rs34371898; rs637758; rs5793203; rs550168; rs11494275; rs34952173; rs11402713; rs561237; rs11234703; rs36107930; rs35726265; rs34433932; rs613418; rs12792072; rs35180248; rs10751139; rs12222272; rs655868; rs34237389; rs34730962; rs34249558; rs12098937; rs36078024; rs35193618; rs10583492; rs35420443; rs34837662; rs34902539; rs11234652; rs11607319; rs11828146; rs12270761; rs12276248; rs12293159; rs1452133; rs1938936; rs2034622; rs2051435; rs2051436; rs2051437; rs2051438; rs3741004; rs4393345; rs516066; rs516746; rs567615; rs571006; rs594361; rs615858; rs642245; rs643157; rs674053; rs693817

# Metabolic_Enzyme_26_General_References:
7818469

# Metabolic_Enzyme_26_References:
3068215

# Metabolic_Enzyme_27_ID:
8100

# Metabolic_Enzyme_27_Name:
Glycerol 3-phosphate acyltransferase, mitochondrial

# Metabolic_Enzyme_27_Synonyms:
KIAA1560

# Metabolic_Enzyme_27_Gene_Name:
RP11-426E5.2

# Metabolic_Enzyme_27_Protein_Sequence:
>Glycerol 3phosphate acyltransferase, mitochondrial
MDESALTLGTIDVSYLPHSSEYSVGRCKHTSEEWGECGFRPTIFRSATLKWKESLMSRKR
PFVGRCCYSCTPQSWDKFFNPSIPSLGLRNVIYINETHTRHRGWLARRLSYVLFIQERDV
HKGMFATNVTENVLNSSRVQEAIAEVAAELNPDGSAQQQSKAVNKVKKKAKRILQEMVAT
VSPAMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLT
FILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRLDETPDGRKDVLYRALLHGHI
VELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSTNVIPDILIIPVGISYDRII
EGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGCVRVDFAQPFSLKEYLESQSQKPVSA
LLSLEQALLPAILPSRPSDAADEGRDTSINESRNATDESLRRRLIANLAEHILFTASKSC
AIMSTHIVACLLLYRHRQGIDLSTLVEDFFVMKEEVLARDFDLGFSGNSEDVVMHAIQLL
GNCVTITHTSRNDEFFITPSTTVPSVFELNFYSNGVLHVFIMEAIIACSLYAVLNKRGLG
GPTSTPPNLISQEQLVRKAASLCYLLSNEGTISLPCQTFYQVCHETVGKFIQYGILTVAE
HDDQEDISPSLAEQQWDKKLPEPLSWRSDEEDEDSDFGEEQRDCYLKVLG

# Metabolic_Enzyme_27_Number_of_Residues:
710

# Metabolic_Enzyme_27_Molecular_Weight:
80141

# Metabolic_Enzyme_27_Theoretical_pI:
7.17

# Metabolic_Enzyme_27_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_27_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_27_Specific_Function:
Not Available

# Metabolic_Enzyme_27_Pathway:
Not Available

# Metabolic_Enzyme_27_Reaction:
Not Available

# Metabolic_Enzyme_27_Pfam_Domain_Function:
PF01553:Acyltransferase

# Metabolic_Enzyme_27_Signals:
None

# Metabolic_Enzyme_27_Transmembrane_Regions:
None

# Metabolic_Enzyme_27_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_27_EC_Link:
EC 2.3.1.15

# Metabolic_Enzyme_27_GenBank_ID_Protein:
55665204

# Metabolic_Enzyme_27_SwissProt_ID:
Q5VW52_HUMAN (Q5VW52)

# Metabolic_Enzyme_27_swissprot_Name:
Not Available

# Metabolic_Enzyme_27_Genecard_id:
RP11-426E5.2

# Metabolic_Enzyme_27_Geneatlas_id:
RP11-426E5.2

# Metabolic_Enzyme_27_hgnc_id:
HGNC:24865

# Metabolic_Enzyme_27_PDB_ID:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_27_Subcellular_Location:
Not Available

# Metabolic_Enzyme_27_Gene_Sequence:
>2487 bp
ATGGATGAATCTGCACTGACCCTTGGTACAATAGATGTTTCTTATCTGCCACATTCATCA
GAATACAGTGTTGGTCGATGTAAGCACACAAGTGAGGAATGGGGTGAGTGTGGCTTTAGA
CCCACCATCTTCAGATCTGCAACTTTAAAATGGAAAGAAAGCCTAATGAGTCGGAAAAGG
CCATTTGTTGGAAGATGTTGTTACTCCTGCACTCCCCAGAGCTGGGACAAATTTTTCAAC
CCCAGTATCCCGTCTTTGGGTTTGCGGAATGTTATTTATATCAATGAAACTCACACAAGA
CACCGCGGATGGCTTGCAAGACGCCTTTCTTACGTTCTTTTTATTCAAGAGCGAGATGTG
CATAAGGGCATGTTTGCCACCAATGTGACTGAAAATGTGCTGAACAGCAGTAGAGTACAA
GAGGCAATTGCAGAAGTGGCTGCTGAATTAAACCCTGATGGTTCTGCCCAGCAGCAATCA
AAAGCCGTTAACAAAGTGAAAAAGAAAGCTAAAAGGATTCTTCAAGAAATGGTTGCCACT
GTCTCACCGGCAATGATCAGACTGACTGGGTGGGTGCTGCTAAAACTGTTCAACAGCTTC
TTTTGGAACATTCAAATTCACAAAGGTCAACTTGAGATGGTTAAAGCTGCAACTGAGACG
AATTTGCCGCTTCTGTTTCTACCAGTTCATAGATCCCATATTGACTATCTGCTGCTCACT
TTCATTCTCTTCTGCCATAACATCAAAGCACCATACATTGCTTCAGGCAATAATCTCAAC
ATCCCAATCTTCAGTACCTTGATCCATAAGCTTGGGGGCTTCTTCATACGACGAAGGCTC
GATGAAACACCAGATGGACGGAAAGATGTTCTCTATAGAGCTTTGCTCCATGGGCATATA
GTTGAATTACTTCGACAGCAGCAATTCTTGGAGATCTTCCTGGAAGGCACACGTTCTAGG
AGTGGAAAAACCTCTTGTGCTCGGGCAGGACTTTTGTCAGTTGTGGTAGATACTCTGTCT
ACCAATGTCATCCCAGACATCTTGATAATACCTGTTGGAATCTCCTATGATCGCATTATC
GAAGGTCACTACAATGGTGAACAACTGGGCAAACCTAAGAAGAATGAGAGCCTGTGGAGT
GTAGCAAGAGGTGTTATTAGAATGTTACGAAAAAACTATGGTTGTGTCCGAGTGGATTTT
GCACAGCCATTTTCCTTAAAGGAATATTTAGAAAGCCAAAGTCAGAAACCGGTGTCTGCT
CTACTTTCCCTGGAGCAAGCGTTGTTACCAGCTATACTTCCTTCAAGACCCAGTGATGCT
GCTGATGAAGGTAGAGACACGTCCATTAATGAGTCCAGAAATGCAACAGATGAATCCCTA
CGAAGGAGGTTGATTGCAAATCTGGCTGAGCATATTCTATTCACTGCTAGCAAGTCCTGT
GCCATTATGTCCACACACATTGTGGCTTGCCTGCTCCTCTACAGACACAGGCAGGGAATT
GATCTCTCCACATTGGTCGAAGACTTCTTTGTGATGAAAGAGGAAGTCCTGGCTCGTGAT
TTTGACCTGGGGTTCTCAGGAAATTCAGAAGATGTAGTAATGCATGCCATACAGCTGCTG
GGAAATTGTGTCACAATCACCCACACTAGCAGGAACGATGAGTTTTTTATCACCCCCAGC
ACAACTGTCCCATCAGTCTTCGAACTCAACTTCTACAGCAATGGGGTACTTCATGTCTTT
ATCATGGAGGCCATCATAGCTTGCAGCCTTTATGCAGTTCTGAACAAGAGGGGACTGGGG
GGTCCCACTAGCACCCCACCTAACCTGATCAGCCAGGAGCAGCTGGTGCGGAAGGCGGCC
AGCCTGTGCTACCTTCTCTCCAATGAAGGCACCATCTCACTGCCTTGCCAGACATTTTAC
CAAGTCTGCCATGAAACAGTAGGAAAGTTTATCCAGTATGGCATTCTTACAGTGGCAGAG
CACGATGACCAGGAAGATATCAGTCCTAGTCTTGCTGAGCAGCAGTGGGACAAGAAGCTT
CCAGAACCTTTGTCTTGGAGAAGTGATGAAGAAGATGAAGACAGTGACTTTGGGGAGGAA
CAGCGAGATTGCTACCTGAAGGTGAGCCAATCCAAGGAGCACCAGCAGTTTATCACCTTC
TTACAGAGACTCCTTGGGCCTTTGCTGGAGGCCTACAGCTCTGCTGCCATCTTTGTTCAC
AACTTCAGTGGTCCTGTTCCAGAACCTGAGTATCTGCAAAAGTTGCACAAATACCTAATA
ACCAGAACAGAAAGAAATGTTGCAGTATATGCTGAGAGTGCCACATATTGTCTTGTGAAG
AATGCTGTGAAAATGTTTAAGGATATTGGGGTTTTCAAGGAGACCAAACAAAAGAGAGTG
TCTGTTTTAGAACTGAGCAGCACTTTTCTACCTCAATGCAACCGACAAAAACTTCTAGAA
TATATTCTGAGTTTTGTGGTGCTGTAG

# Metabolic_Enzyme_27_GenBank_ID_Gene:
AL391986

# Metabolic_Enzyme_27_Chromosome_Location:
Not Available

# Metabolic_Enzyme_27_Locus:
Not Available

# Metabolic_Enzyme_27_SNPs:
Not Available

# Metabolic_Enzyme_27_General_References:
Not Available

# Metabolic_Enzyme_27_References:
10709629; 14668349

# Metabolic_Enzyme_28_ID:
8487

# Metabolic_Enzyme_28_Name:
Glycerol kinase, testis specific 1

# Metabolic_Enzyme_28_Synonyms:
ATP:glycerol 3- phosphotransferase; Glycerokinase; GK

# Metabolic_Enzyme_28_Gene_Name:
GK3P

# Metabolic_Enzyme_28_Protein_Sequence:
>Glycerol kinase, testis specific 1
MAASKKAVLGPLVGAVDQGTSSTRFLVFNSRTAELLSHHQVEIKQEFPREGWVEQDPKEI
LHSVYECIEKTCEKLGQLNIGISNIKAIGVSNQRETTVAWDKITGEPLYNAVVWLDLRTQ
STVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEKRALFGTIDS
WLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKQLCEFFGIPMEILPHVRSSSEIY
GLMKAGALEGVPISGCLGDQSAALVGQMCFQIGQAKNTYGTGCFLLCNTGHKCVFSDHGL
LTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKTSEEIEKLAKEVGTSYGCYF
VPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLS
HLQVDGGMTSNKILMQLQADILYIPVVKPLMPETTALGAAMAAGAAEGVDVWSLEPEDLS
AVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSPEGGDPSVFCSLPLGFFIVSSM
AMLIGARYISGIP

# Metabolic_Enzyme_28_Number_of_Residues:
553

# Metabolic_Enzyme_28_Molecular_Weight:
60570

# Metabolic_Enzyme_28_Theoretical_pI:
6.35

# Metabolic_Enzyme_28_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  glycerol kinase activity
 ||
>>>
 Process:  cellular metabolism
Process:  alcohol metabolism
Process:  polyol metabolism
Process:  glycerol metabolism
Process:  glycerol-3-phosphate metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_28_General_Function:
Energy production and conversion

# Metabolic_Enzyme_28_Specific_Function:
Key enzyme in the regulation of glycerol uptake and metabolism

# Metabolic_Enzyme_28_Pathway:
map00561  Glycerolipid metabolism

# Metabolic_Enzyme_28_Reaction:
ATP + glycerol = ADP + sn-glycerol 3-phosphate

# Metabolic_Enzyme_28_Pfam_Domain_Function:
PF02782:FGGY_C
PF00370:FGGY_N

# Metabolic_Enzyme_28_Signals:
Not Available

# Metabolic_Enzyme_28_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_28_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_28_EC_Link:
EC 2.7.1.30

# Metabolic_Enzyme_28_GenBank_ID_Protein:
515029

# Metabolic_Enzyme_28_SwissProt_ID:
GLPK3_HUMAN (Q14409)

# Metabolic_Enzyme_28_swissprot_Name:
Not Available

# Metabolic_Enzyme_28_Genecard_id:
GK3P

# Metabolic_Enzyme_28_Geneatlas_id:
GK3P

# Metabolic_Enzyme_28_hgnc_id:
HGNC:4292

# Metabolic_Enzyme_28_PDB_ID:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_28_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; peripheral membrane protein; cytoplasmic side. Cytoplasm (By similarity). Note=In sperm the majority of the enzyme is bound to mitochondria (By similarity)

# Metabolic_Enzyme_28_Gene_Sequence:
>1662 bp
ATGGCAGCCTCAAAGAAGGCAGTTTTGGGGCCATTGGTGGGGGCAGTGGACCAAGGCACC
AGTTCCACGCGCTTTTTGGTTTTCAATTCAAGAACAGCTGAACTACTTAGTCATCATCAA
GTGGAAATAAAACAAGAGTTCCCAAGAGAAGGATGGGTGGAACAGGACCCTAAGGAAATT
CTACATTCTGTCTATGAGTGTATAGAGAAAACATGTGAGAAACTTGGACAGCTCAATATT
GGTATTTCCAACATAAAAGCTATTGGTGTCAGCAACCAGAGGGAAACCACCGTAGCCTGG
GACAAGATAACTGGAGAGCCTCTCTACAATGCTGTAGTGTGGCTTGATCTAAGAACACAG
TCTACCGTTGAGAGTCTTAGTAAAAGAATTCCAGGAAATAATAACTTTGTCAAGTCCAAG
ACAGGCCTTCCACTTAGCACTTACTTCAGTGCAGTGAAACTTCGCTGGCTCCTCGACAAT
GTGAGAAAAGTTCAAAAGGCCGTTGAAGAAAAACGAGCTCTTTTTGGGACTATTGATTCA
TGGCTTATTTGGAGTTTGACAGGAGGCGTCAATGGAGGTGTCCACTGTACAGATGTAACA
AATGCAAGTAGGACTATGCTTTTCAACATTCATTCTTTGGAATGGGATAAACAACTCTGT
GAATTTTTTGGAATTCCAATGGAAATTCTTCCACATGTTCGGAGTTCTTCTGAGATCTAT
GGCCTAATGAAAGCGGGGGCCTTGGAAGGTGTGCCAATATCTGGGTGTTTAGGGGACCAG
TCTGCTGCACTGGTGGGACAAATGTGCTTCCAGATTGGACAAGCCAAAAATACGTATGGA
ACAGGATGTTTCTTACTATGTAATACAGGCCATAAGTGTGTATTTTCTGATCATGGCCTT
CTCACCACAGTGGCTTACAAACTTGGCAGAGACAAACCGGTATATTACGCTTTGGAAGGT
TCTGTAGCTATAGCTGGTGCTGTTATTCGCTGGCTAAGAGACAATCTTGGAATTATAAAG
ACCTCAGAAGAAATTGAAAAACTTGCTAAAGAAGTAGGTACTTCTTATGGCTGCTACTTC
GTCCCAGCATTTTCGGGGTTATATGCACCTTATTGGGAGCCCAGCGCAAGAGGGATAATC
TGTGGACTCACTCAATTCACGAATAAATGCCATATTGCTTTTGCTGCATTAGAAGCTGTT
TGTTTCCAAACTCGAGAGATTTTGGATGCCATGAATCGAGACTGTGGAATTCCACTCAGT
CATTTGCAGGTTGATGGAGGAATGACCAGCAACAAAATTCTTATGCAGCTACAAGCAGAC
ATTCTGTATATTCCAGTAGTGAAGCCCTTGATGCCCGAAACCACTGCACTGGGTGCTGCC
ATGGCGGCAGGGGCTGCAGAAGGAGTCGACGTATGGAGTCTTGAACCTGAGGATTTGTCC
GCCGTCACGATGGAGCGGTTTGAACCTCAGATTAATGCTGAGGAAAGTGAAATTCGTTAT
TCTACATGGAAGAAAGCTGTGATGAAGTCAATGGGTTGGGTTACAACTCAATCTCCAGAA
GGTGGTGACCCTAGTGTCTTCTGTAGTCTGCCCTTGGGCTTTTTTATAGTGAGTAGCATG
GCAATGTTAATCGGAGCAAGGTACATCTCAGGTATTCCATAA

# Metabolic_Enzyme_28_GenBank_ID_Gene:
X78711

# Metabolic_Enzyme_28_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_28_Locus:
4q32.1

# Metabolic_Enzyme_28_SNPs:
Not Available

# Metabolic_Enzyme_28_General_References:
7987308

# Metabolic_Enzyme_28_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7193

# Macromolecular_Interacting_Partner_1_Name:
Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide

# Macromolecular_Interacting_Partner_1_Synonyms:
GRPP; Oxyntomodulin; OXY; OXM; Glucagon; Glucagon-like peptide 1; GLP-1; Glucagon-like peptide 1(7-37; GLP-1(7-37; Glucagon-like peptide 1(7-36; GLP-1(7-36; Glucagon-like peptide 2; GLP-2]

# Macromolecular_Interacting_Partner_1_Gene_Name:
GCG

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Glucagon precursor Contains: Glicentin; Glicentinrelated polypeptide
MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTS
DYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFI
AWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMNTILDNLAARDFINWLIQTKITDRK


# Macromolecular_Interacting_Partner_1_Number_of_Residues:
180

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
20909

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.14

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00123:Hormone_2

# Macromolecular_Interacting_Partner_1_Signals:
1-20

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
183270

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
GLUC_HUMAN (P01275)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
GCG

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
GCG

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:4191

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>543 bp
ATGAAAAGCATTTACTTTGTGGCTGGGTTATTTGTAATGCTGGTACAAGGCAGCTGGCAA
CGTTCCCTTCAAGACACAGAGGAGAAATCCAGATCATTCTCAGCTTCCCAGGCAGACCCA
CTCAGTGATCCTGATCAGATGAACGAGGACAAGCGCCATTCACAGGGCACATTCACCAGT
GACTACAGCAAGTATCTGGACTCCAGGCGTGCCCAAGATTTTGTGCAGTGGTTGATGAAT
ACCAAGAGGAACAGGAATAACATTGCCAAACGTCACGATGAATTTGAGAGACATGCTGAA
GGGACCTTTACCAGTGATGTAAGTTCTTATTTGGAAGGCCAAGCTGCCAAGGAATTCATT
GCTTGGCTGGTGAAAGGCCGAGGAAGGCGAGATTTCCCAGAAGAGGTCGCCATTGTTGAA
GAACTTGGCCGCAGACATGCTGATGGTTCTTTCTCTGATGAGATGAACACCATTCTTGAT
AATCTTGCCGCCAGGGACTTTATAAACTGGTTGATTCAGACCAAAATCACTGACAGGAAA
TAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
J04040

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_1_Locus:
2q36-q37

# Macromolecular_Interacting_Partner_1_SNPs:
rs5645; rs4664448; rs6732914; rs4664449; rs10490424; rs10164435; rs11897425; rs7581952; rs7569992; rs7559086; rs5649; rs4664447; rs5653; rs6727317; rs13306377; rs5647; rs5654; rs13306376; rs1990761; rs6717659; rs13001107; rs16846320; rs13416088; rs35424779; rs6717263; rs3811540; rs6717609; rs35328019; rs5650; rs11552334; rs35920035; rs11552338; rs1042405; rs11552330; rs11552335; rs34074912; rs11552339; rs17711059; rs11552332; rs16846334; rs11552331; rs11552336; rs35185096; rs35902561; rs35301560; rs10557377; rs10603613; rs5648; rs34801095; rs10671204; rs33949193; rs5652; rs5646; rs11378120; rs7569999; rs34405490; rs5651; rs11898004; rs35323923; rs13429709; rs10696486; rs34204135; rs35205044; rs3811539; rs7590067; rs11692314; rs17762054; rs41368446; rs34932341; rs10170813; rs10189636; rs11888030; rs13010545; rs13028221; rs2111487; rs2193494; rs2216338; rs2389680; rs2389681; rs3761656; rs4664450; rs6704722; rs6733736; rs7599142

# Macromolecular_Interacting_Partner_1_General_References:
2901414; 3725587; 6877358; 2753890; 8482423; 14557443; 14632334; 9287128; 12651102; 12554744; 12626323; 10605628; 9667960; 11943215; 12627948

# Macromolecular_Interacting_Partner_1_References:
3663184

# Macromolecular_Interacting_Partner_2_ID:
7549

# Macromolecular_Interacting_Partner_2_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
INS

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_2_Signals:
1-24

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
INS

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_2_Locus:
11p15.5

# Macromolecular_Interacting_Partner_2_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_2_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_2_References:
11060297

# Macromolecular_Interacting_Partner_3_ID:
6118

# Macromolecular_Interacting_Partner_3_Name:
Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic

# Macromolecular_Interacting_Partner_3_Synonyms:
GPD-C; GPDH-C

# Macromolecular_Interacting_Partner_3_Gene_Name:
GPD1

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Glycerol3phosphate dehydrogenase NAD+, cytoplasmic
MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHEN
VKYLPGHKLPPNVVAVPDVVQAAEDADILIFVVPHQFIGKICDQLKGHLKANATGISLIK
GVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCETTIGCKDPAQGQLLKEL
MQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAK
LFCSGPVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGP
ETARELYSILQHKGLVDKFPLFMAVYKVCYEGQPVGEFIHCLQNHPEHM

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
349

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
37568

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.10

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  glycerol-3-phosphate dehydrogenase (NAD+) activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
 ||
>>>
Process:  glycerol-3-phosphate catabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  polyol metabolism
Process:  glycerol metabolism
Process:  glycerol-3-phosphate metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm
Component:  protein complex
Component:  unlocalized protein complex
Component:  glycerol-3-phosphate dehydrogenase complex

# Macromolecular_Interacting_Partner_3_General_Function:
Energy production and conversion 

# Macromolecular_Interacting_Partner_3_Specific_Function:
sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH

# Macromolecular_Interacting_Partner_3_Pathway:
map00564  Glycerophospholipid metabolism

# Macromolecular_Interacting_Partner_3_Reaction:
sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF07479:NAD_Gly3P_dh_C;
PF01210:NAD_Gly3P_dh_N

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
EC 1.1.1.8

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
508487

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
GPDA_HUMAN (P21695)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
GPD1

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
GPD1

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:4455

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1050 bp
ATGGCTAGCAAGAAAGTCTGCATTGTAGGCTCCGGGAACTGGGGCTCAGCCATCGCCAAG
ATCGTGGGTGGCAATGCAGCCCAGCTCGCACAGTTTGACCCACGGGTGACCATGTGGGTA
TTTGAGGAAGACATTGGAGGCAAAAAGCTGACTGAGATCATCAACACGCAGCATGAGAAT
GTCAAATACCTGCCAGGGCACAAGTTGCCCCCAAATGTGGTGGCTGTCCCAGATGTGGTC
CAGGCTGCAGAGGATGCTGACATCCTGATCTTTGTGGTGCCCCATCAGTTCATCGGCAAG
ATCTGTGACCAGCTCAAGGGCCATCTGAAGGCAAACCCCACTGGCATATCTCTTATTAAG
GGGGTAGACGAGGGCCCCAATGGGCTGAAGCTCATCTCGGAAGTGATTGGGGAGCGCCTC
GGCATCCCCATGAGTGTGCTGATGGGGGCCAACATTGCCAGCGAGGTGGCTGATGAGAAG
TTCTGTGAGACAACCATTGGCTGCAAGGACCCGGCCCAGGGACAACTCCTGAAAGAGCTG
ATGCAGACACCAAACTTCCGTATCACAGTGGTGCAAGAGGTGGACACAGTAGAGATCTGT
GGAGCCTTAAAGAATGTAGTGGCCGTGGGGGCTGGCTTCTGTGATGGCCTGGGCTTTGGC
GACAACACCAAGGCGGCAGTGATCCGGCTGGGACTCATGGAGATGATAGCCTTCGCCAAG
CTCTTCTGCAGTGGCCCTGTGTCCTCTGCCACCTTCTTGGAGAGCTGTGGTGTTGCTGAC
CTGATCACTACCTGCTATGGAGGGCGGAACCGGAAAGTGGCTGAGGCCTTTGCGCGTACA
GGAAAGTCCATTGAGCAGCTGGAGAAAGAGTTGCTGAATGGGCAGAAACTGCAGGGGCCC
GAGACAGCCCGGGAGCTATACAGCATCCTCCAGCACAAGGGCCTGGTAGACAAGTTTCCC
TTGTTCATGGCTGTGTACAAGGTGTGCTACGAGGGCCAGCCAGTGGGTGAATTCATCCAC
TGCCTGCAGAATCATCCAGAACATATGTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
L34041

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_3_Locus:
12q12-q13

# Macromolecular_Interacting_Partner_3_SNPs:
rs2232202; rs836180; rs836178; rs836179; rs2232208; rs1128867; rs35428353; rs34944386; rs11541968; rs2232207; rs34783513; rs1046194; rs17848998; rs34423210; rs34013306; rs35256655; rs34005044; rs2232203; rs17848997; rs2232206; rs2232205; rs34537997; rs34025341; rs17848999; rs34926030; rs2232209; rs2232204; rs17848996; rs3813525; rs3841318; rs3813524; rs1050728; rs1050729; rs1059627; rs1063528; rs10817; rs12309742; rs1389280; rs1554844; rs17124432; rs17124448; rs7139363; rs7307230; rs7308474; rs7961065; rs7961112; rs7968119; rs836172; rs836177

# Macromolecular_Interacting_Partner_3_General_References:
7772607; 2398890

# Macromolecular_Interacting_Partner_3_References:
10217506; 6795189; 8935650; 9234667

# Macromolecular_Interacting_Partner_4_ID:
6174

# Macromolecular_Interacting_Partner_4_Name:
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

# Macromolecular_Interacting_Partner_4_Synonyms:
Phosphoenolpyruvate carboxylase; PEPCK-C

# Macromolecular_Interacting_Partner_4_Gene_Name:
PCK1

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Phosphoenolpyruvate carboxykinase, cytosolic 
GTPMPPQLQNGLNLSAKVVQGSLDSLPQAVREFLENNAELCQPDHIHICDGSEEENGRLL
GQMEEEGILRRLKKYDNCWLALTDPRDVARIESKTVIVTQEQRDTVPIPKTGLSQLGRWM
SEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLSKIGIELTDSPYVVASMRIMTRMG
TPVLEAVGDGEFVKCLHSVGCPLPLQKPLVNNWPCNPELTLIAHLPDRREIISFGSGYGG
NSLLGKKCFALRMASRLAKEEGWLAEHMLILGITNPEGEKKYLAAAFPSACGKTNLAMMN
PSLPGWKVECVGDDIAWMKFDAQGHLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIF
TNVAETSDGGVYWEGIDEPLASGVTITSWKNKEWSSEDGEPCAHPNSRFCTPASQCPIID
AAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKIIMH
DPFAMRPFFGYNFGKYLAHWLSMAQHPAAKLPKIFHVNWFRKDKEGKFLWPGFGENSRVL
EWMFNRIDGKASTKLTPIGYIPKEDALNLKGLGHINMMELFSISKEFWEKEVEDIEKYLE
DQVNADLPCEIEREILALKQRISQM

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
622

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
69195

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.05

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  guanyl nucleotide binding
Function:  GTP binding
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
Function:  phosphoenolpyruvate carboxykinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  gluconeogenesis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Energy production and conversion 

# Macromolecular_Interacting_Partner_4_Specific_Function:
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO(2)

# Macromolecular_Interacting_Partner_4_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00620  Pyruvate metabolism

# Macromolecular_Interacting_Partner_4_Reaction:
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00821:PEPCK

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
EC 4.1.1.32

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
189945

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
PPCKC_HUMAN (P35558)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
PCK1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
PCK1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:8724

# Macromolecular_Interacting_Partner_4_PDB_ID:
1NHX

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1869 bp
ATGCCTCCTCAGCTGCAAAACGGCCTGAACCTCTCGGCCAAAGTTGTCCAGGGAAGCCTG
GACAGCCTGCCCCAGGCAGTGAGGGAGTTTCTCGAGAATAACGCTGAGCTGTGTCAGCCT
GATCACATCCACATCTGTGACGGCTCTGAGGAGGAGAATGGGCGGCTTCTGGGCCAGATG
GAGGAAGAGGGCATCCTCAGGCGGCTGAAGAAGTATGACAACTGCTGGTTGGCTCTCACT
GACCCCAGGGATGTGGCCAGGATCGAAAGCAAGACGGTTATCGTCACCCAAGAGCAAAGA
GACACAGTGCCCATCCCCAAAACAGGCCTCAGCCAGCTCGGTCGCTGGATGTCAGAGGAG
GATTTTGAGAAAGCGTTCAATGCCAGGTTCCCAGGGTGCATGAAAGGTCGCACCATGTAC
GTCATCCCATTCAGCATGGGGCCGCTGGGCTCACCTCTGTCGAAGATCGGCATCGAGCTG
ACGGATTCGCCCTACGTGGTGGCCAGCATGCGGATCATGACGCGGATGGGCACGCCCGTC
CTGGAAGCACTGGGCGATGGGGAGTTTGTCAAATGCCTCCATTCTGTGGGGTGCCCTCTG
CCTTTACAAAAGCCTTTGGTCAACAACTGGCCCTGCAACCCGGAGCTGACGCTCATCGCC
CACCTGCCTGACCGCAGAGAGATCATCTCCTTTGGCAGTGGGTACGGCGGGAACTCGCTG
CTCGGGAAGAAGTGCTTTGCTCTCAGGATGGCCAGCCGGCTGGCAGAGGAGGAAGGGTGG
CTGGCAGAGCACATGCTGATTCTGGGTATAACCAACCCTGAGGGTGAGAAGAAGTACCTG
GCGGCCGCATTTCCCAGCGCCTGCGGGAAGACCAACCTGGCCATGATGAACCCCAGCCTC
CCCGGGTGGAAGGTTGAGTGCGTCGGGGATGACATTGCCTGGATGAAGTTTGACGCACAA
GGTCATTTAAGGGCCATCAACCCAGAAAATGGCTTTTTCGGTGTCGCTCCTGGGACTTCA
GTGAAGACCAACCCCAATGCCATCAAGACCATCCAGAAGAACACAATCTTTACCAATGTG
GCCGAGACCAGCGACGGGGGCGTTTACTGGGAAGGCATTGATGAGCCGCTAGCTTCAGGC
GTCACCATCACGTCCTGGAAGAATAAGGAGTGGAGCTCAGAGGATGGGGAACCTTGTGCC
CACCCCAACTCGAGGTTCTGCACCCCTGCCAGCCAGTGCCCCATCATTGATGCTGCCTGG
GAGTCTCCGGAAGGTGTTCCCATTGAAGGCATTATCTTTGGAGGCCGTAGACCTGCTGGT
GTCCCTCTAGTCTATGAAGCTCTCAGCTGGCAACATGGAGTCTTTGTGGGGGCGGCCATG
AGATCAGAGGCCACAGCGGCTGCAGAACATAAAGGCAAAATCATCATGCATGACCCCTTT
GCCATGCGGCCCTTCTTTGGCTACAACTTCGGCAAATACCTGGCCCACTGGCTTAGCATG
GCCCAGCACCCAGCAGCCAAACTGCCCAAGATCTTCCATGTCAACTGGTTCCGGAAGGAC
AAGGAAGGCAAATTCCTCTGGCCAGGCTTTGGAGAGAACTCCAGGGTGCTGGAGTGGATG
TTCAACCGGATCGATGGAAAAGCCAGCACCAACGTCACGCCCATAGGCTACATCCCCAAG
GAGGATGCCCTGAACCTGAAAGGCCTGGGGCACATCAACATGATGGAGCTTTTCAGCATC
TCCAAGGAATTCTGGGACAAGGAGGTGGAAGACATCGAGAAGTATCTGGTGGATCAAGTC
AATGCCGACCTCCCCTGTGAAATCGAGAGAGAGATCCTTGCCTTGAAGCAAAGAATAAGC
CAGATGTAA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
L05144

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_4_Locus:
20q13.31

# Macromolecular_Interacting_Partner_4_SNPs:
rs707555; rs8192708; rs1804160; rs11552145; rs28359542; rs1062601; rs2070756; rs28383584; rs28359546; rs1062600; rs6070157; rs1042521; rs1042523; rs28359547; rs28359544; rs1042531; rs28359554; rs28383583; rs1023049; rs2179706; rs2236745; rs2070755; rs1040566; rs17847710; rs6025629; rs8123020; rs2236744; rs28359537; rs28359552; rs1328757; rs1328756; rs2071023; rs28383582; rs28359556; rs28383575; rs28383578; rs28383576; rs1042529; rs28383585; rs34103538; rs17847705; rs1042530; rs41302559; rs28359550; rs28383586; rs6092497; rs11552146; rs6128079; rs6128078; rs17847716; rs6070155; rs34053667; rs35463004; rs11470969; rs6070159; rs35421260; rs11471113; rs6070156; rs34726336; rs17847706; rs36212750; rs34957652; rs36204795; rs6025630; rs35760901; rs34351914; rs1042532; rs28682317; rs7351534; rs28359539; rs35295536; rs28359541; rs28359543; rs28359538; rs28359551; rs28359540; rs28359549; rs28359548; rs6070158; rs6070160; rs28383577; rs34751656; rs28383580; rs28383579; rs28383581; rs1022570; rs34808822; rs28359555; rs6025628; rs28359557; rs35912384; rs1004776; rs1022571; rs11908628; rs12479913; rs12481672; rs1543375; rs1569718; rs16981144; rs17411842; rs17411883; rs17411904; rs17411973; rs17496809; rs2073144; rs2143666; rs2179707; rs2206851; rs2235826; rs2865391; rs2902994; rs3795120; rs6015032; rs6015034; rs6025620; rs6025622; rs6025625; rs6025627; rs6025631; rs6025633; rs6025634; rs6025635; rs6025637; rs6025639; rs6064564; rs6064565; rs6064566; rs6070148; rs6070149; rs6070152; rs6070154; rs6070161; rs6070163; rs6099674; rs6123706; rs6123707; rs6128074; rs6128076; rs6128077; rs6128083; rs7274434; rs7363892; rs742725; rs8117078

# Macromolecular_Interacting_Partner_4_General_References:
8490617; 8325643; 11780052; 8547315; 11851336

# Macromolecular_Interacting_Partner_4_References:
16847310; 8912704

# Macromolecular_Interacting_Partner_5_ID:
5264

# Macromolecular_Interacting_Partner_5_Name:
Fatty acid synthase

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
FASN

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Fatty acid synthase
MEEVVIAGMSGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGLYGLPRRSGKLKDLSRF
DASFFGVHPK
QAHTMDPQLRLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETSEA
LSRDPETLVGYSMVGCQRAMM
ANRLSFFFDFRGPSIALDTACSSSLMALQNAYQAIHSG
QCPAAIVGGINVLLKPNTSVQFLRLGMLSPEG
TCKAFDTAGNGYCRSEGVVAVLLTKKS
LARRVYATILNAGTNTDGFKEQGVTFPSGDIQEQLIRSLYQSA
GVAPESFEYIEAHGTG
TKVGDPQELNGITRALCATRQEPLLIGSTKSNMGHPEPASGLAALAKVLLSLEH
GLWAP
NLHFHSPNPEIPALLDGRLQVVDQPLPVRGGNVGINSFGFGGSNVHIILRPNTQPPPAPA
PHATL
PRLLRASGRTPEAVQKLLEQGLRHSQDLAFLSMLNDIAAVPATAMPFRGYAVLG
GERGGPEVQQVPAGER
PLWFICSGMGTQWRGMGLSLMRLDRFRDSILRSDEAVKPFGLK
VSQLLLSTDESTFDDIVHSFVSLTAIQ
IGLIDLLSCMGLRPDGIVGHSLGEVACGYADG
CLSQEEAVLAAYWRGQCIKEAHLPPGAMAAVGLSWEEC
KQRCPPGVVPACHNSKDTVTI
SGPQAPVFEFVEQLRKEGVFAKEVRTGGMAFHSYFMEAIAPPLLQELKK
VIREPKPRSA
RWLSTSIPEAQWHSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPHALLQAV

LKRGLKPSCTIIPLMKKDHRDNLEFFLAGIGRLHLSGIDANPNALFPPVEFPAPRGTPL
ISPLIKWDHSL
AWDVPAAEDFPNGSGSPSAAIYNIDTSSESPDHYLVDHTLDGRVLFPA
TGYLSIVWKTLARALGLGVEQL
PVVFEDVVLHQATILPKTGTVSLEVRLLEASRAFEVS
ENGNLVVSGKVYQWDDPDPRLFDHPESPTPNPT
EPLFLAQAEVYKELRLRGYDYGPHFQ
GILEASLEGDSGRLLWKDNWVSFMDTMLQMSILGSAKHGLYLPT
RVTAIHIDPATHRQK
LYTLQDKAQVADVVVSRWLRVTVAGGVHISGLHTESAPRRQQEQQVPILEKFCFT
PHTE
EGCLSERAALQEELQLCKGLVQALQTTVTQQGLKMVVPGLDGAQIPRDPSQQELPRLLSA
ACRLQL
NGNLQLELAQVLAQERPKLPEDPLLSGLLDSPALKACLDTAVENMPSLKMKVV
EVLAGHGHLYSRIPGLL
SPHPLLQLSYTATDRHPQALEAAQAELQQHDVAQGQWDPADP
APSALGSADLLVCNCAVAALGDPASALS
NMVAALREGGFLLLHTLLRGHPLGDIVAFLT
STEPQYGQGILSQDAWESLFSRVSLRLVGLKKSFYGSTL
FLCRRPTPQDSPIFLPVDDT
SFRWVESLKGILADEDSSRPVWLKAINCATSGVVGLVNCLRREPGGNRLR
CVLLSNLSS
TSHVPEVDPGSAELQKVLQGDLVMNVYRDGAWGAFRHFLLEEDKPEEPTAHAFVSTLTRG
D
LSSIRWVCSSLRHAQPTCPGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSL
LGMEFSGRDASG
KRVMGLVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYY
ALVVRGRVRPGETLLIHSGSGGV
GQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLD
STSFANSRDTSFEQHVLWHTGGKGVDLVLNSLAE
EKLQASVRCLATHGRFLEIGKFDLS
QNHPLGMAIFLKNVTFHGVLLDAFFNESSADWREVWALVQAGIRD
GVVRPLKCTVFHGA
QVEDAFRYMAQGKHIGKVVVQVLAEEPEAVLKGAKPKLMSAISKTFCPAHKSYIIA
GGL
GGFGLELAQWLIQRGVQKLVLTSRSGIRTGYQAKQVRRWRRQGVQVQVSTSNISSLEGAR
GLIAEAA
QLGPVGGVFNLAVVLRDGLLENQTPEFFQDVCKPKYSGTLNLDRVTREACPE
LDYFVVFSSVSCGRGNAG
QSNYGFANSAMERICEKRRHEGLPGLAVQWGAIGDVGILVE
TMSTNDTIVSGTLPQRMASCLEVLDLFLN
QPHMVLSSFVLAEKAAAYRDRDSQRDLVEA
VAHILGIRDLAAVNLDSSLADLGLDSLMSVEVRQTLEREL
NLVLSVREVRQLTLRKLQE
LSSKADEASELACPTPKEDGLAQQQTQLNLRSLLVNPEGPTLMRLNSVQSS
ERPLFLVH
PIEGSTTVFHSLASRLSIPTYGLQCTRAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYS
YG
ACVAFEMCSQLQAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCEAEAETEA
ICFFVQQFTDMEH
NRVLEALLPLKGLEERVAAAVDLIIKSHQGLDRQELSFAARSFYYK
LRAAEQYTPKAKYHGNVMLLRAKT
GGAYGEDLGADYNLSQVCDGKVSVHVIEGDHRTLL
EGSGLESIISIIHSSLAEPRVSVREG

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
2511

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
273403

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.39

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  oxidoreductase activity
Function:  vitamin binding
Function:  phosphopantetheine binding
Function:  binding
Function:  cofactor binding
Function:  catalytic activity
Function:  transferase activity
 ||
>>>
Process:  biosynthesis
Process:  cellular metabolism
Process:  organic acid metabolism
Process:  carboxylic acid metabolism
Process:  fatty acid metabolism
Process:  fatty acid biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Macromolecular_Interacting_Partner_5_Specific_Function:
Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein

# Macromolecular_Interacting_Partner_5_Pathway:
map00061  Fatty acid biosynthesis (path 1)

# Macromolecular_Interacting_Partner_5_Reaction:
(3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00698:Acyl_transf_1;
PF00106:adh_short;
PF00107:ADH_zinc_N;
PF00109:ketoacyl-synt;
PF02801:Ketoacyl-synt_C;
PF08242:Methyltransf_12;
PF00550:PP-binding;
PF00975:Thioesterase

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
EC 2.3.1.85;EC 2.3.1.38;E

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
1049053

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
FAS_HUMAN (P49327)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
FASN

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
FASN

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:3594

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>7515 bp

ATGGAGGAGGTGGTGATTGCCGGCATGTTCGGGAAGCTGCCAGAGTCGGAGAACTTGCA
GGAGTTCTGGG
ACAACCTCATCGGCGGTGTGGACATGGTCACGGACGATGACCGTCGCT
GGAAGGCTGGGCTCTACGGCCT
GCCCCGGCGGTCCGGCAAGCTGAAGGACCTGTCTAGG
TTTGATGCCTCCTTCTTCGGAGTCCACCCCAAG
CAGGCACACACGATGGACCCTCAGCT
GCGGCTGCTGCTGGAAGCTACCTATGAAGCCATCGTGGACGGAG
GCATCAACCCAGATT
CACTCCGAGGAACACACACTGGCGTCTGGGTGGGCGTGAGCGGCTCTGAGACCTC
GGAG
GCCCTGAGCCGAGACCCCGAGACACTCGTGGGCTACAGCATGGTGGGCTGCCAGCGAGCG
ATGATG
GCCAACCGGCTCTCCTTCTTCTTCGACTTCAGAGGGCCCAGCATCGCACTGGA
CACAGCCTGCTCCTCCA
GCCTGATGGCCCTGCAGAACGCCTACCAGGCCATCCACAGCG
GGCAGTGCCCTGCCGCCATCGTGGGGGG
CATCAACGTCCTGCTGAAGCCCAACACCTCC
GTGCAGTTCTTGAGGCTGGGGATGCTCAGCCCCGAGGGC
ACCTGCAAGGCCTTCGACAC
AGCGGGGAATGGGTACTGCCGCTCGGAGGGTGTGGTGGCTGTCCTGCTGA
CCAAGAAGT
CCCTGGCCCGGAAGGTCTACACCACCATCCTGAACAAAGGCACCAATACAGATGGCTTCA
A
GGAGCAAGGCGTGACCTTCCCTCAGGATATCCAGGAGCAGCCTATCCGCTCGTTGTAC
CAGTCGGCCGGA
GTGGCCCCTGAGTCATTTGAATACATCGAAGCCCACGGACCAGGCAC
CAAGGTGGGCGACCCCCAGGAGC
GTAATGGCATCACCCGAGCCCTGTGCGCCACCCGCC
AGGAGCCGCTGCTCATCGGCTCCACCAAGTCCAA
CATGGGGCACCCGGAGCCAGCCTCG
GGGCTCGACGCCCTGGCCAAGGTGCTGCTGTCCCTGGAGCACGGG
CTCTGGGCCCCCAA
CCTGCACTTCCATAGCCCCAACCCTGAGATCCCAGCGCTGTTGGATGGGCGGCTGC
AGG
TGGTGGACCAGCCCCTGCCCGTCCGTGGCGGCAACGTGGGCATCAACTCCTTTGGCTTCG
GGGGCTC
CAACATGCACATCATCCTGAGGCCCAACACGCAGTCCGCCCCCGCACCCGCC
CCACATGCCACCCTGCCC
CGTCTGCTGCGGGCCAGCGGACGCACCCCTGAGGCCGTGCA
GAAGCTGCTGGAGCAGGGCCTCCGGCACA
GCCAGGGCCTGGCTTTCCTGAGCATGCTGA
ACGACATCGCGGCTGTCCCCGCCACCGCCATGCCCTTCCG
TGGCTACGCTGTGCTGGGT
GGTGAGACGCGGTGGCCCAGAGTGCAGCAGGTGCCCGCTGGCGAGCGCCCG
CTCTGGTT
CATCTGCTCTGGGATGGGCACACAGTGGCGTGGAATGGGGCTGAGCCTTATGCGCCTGGA
CC
GCTTCCGAGATTCCATCCTACGCTCCGATGAGGCTGTGAACCGATTCGGCCTGAAGG
TGTCACAGCTGCT
GCTGAGCACAGACGAGAGCACCTTTGATGACATCGTCCATTCGTTT
GTGAGCCTGACTGCCATCCAGATA
GGCCTCATAGACCTGCTGAGCTGCATGGGACCTGA
GGCAGATGGCATCGTCGGCCACTCCCTGGGGGAGT
GGCTGTCGGTACGCGACGGCTGCC
TGTCCCAGGAGGAGGCCGTCCTCGCTGCCTACTGGAGGGGACAGTG
CATCAAAGAAGCC
CCACTTCCCGCCGGCGCCATGGCAGCCGTGGGCTTGTCCTGGGAGGAGTGTAAACAG
CG
CTGCCCCCCTGCGGTGGTGCCCGCCTGCCACAACTCCAAGGACACAGTCACCATCTCGGG
ACCTCAGG
CCCCGGTGTTTGAGTTCGTGGAGCAGCTGAGGAAGGAGGGTGTGTTTGCCA
AGGAGGTGCGGACCGGCGG
TATGGCCTTCCACTCCTACTTCATGGAGGCCATCGCACCC
CCACTGCTGCAGGAGCTCAAGAAGGTGATC
CGGGAGCCGAAGCCACGTTCAGCCCGCTG
GCTCAGCACCTCTATCCCCGAGGCCCAGTGGCACAGCAGCC
TGGCACGCACGTCTTCCG
CCGAGTACAATGTCAACAACCTGGTGAGCCCTGTGCTGTTCCAGGAGGCCCT
GTGGCAC
GTGCCTGAGCACGCGGTGGTGCTGGAGATCGCCCCGACCCCGTGCCCTCAGGCTGTCCTG
AAG
CGGGTCCGTAAGCCGAGCTGCACCATCATCCCCCGTATGAAGAAGGATCACAGGGA
CAACCTGGAGTTCT
TCCTGGCCGGCATCGGCAGGCTGCACCTCTCAGGCATCGACGCCA
ACCCCAATGCCTTGTTCCCACCTGT
GGAGTCCCCAGCTCCCCGAGGAACTCCCCTCATC
TCCCCACTCATCAAGTGGGACCACAGCCTGGCCTGG
GACGCGCCGGCCGCCGAGGACTT
CCCCAACGGTTCAGGTTCCCCCTCAGCCACCATCTACACATGCACAC
CAAGCTCCGAGT
CTCCTGACCGCTACCTGGTGGACCACACCATCGACGGTCGCGTCCTCTTCCCCGCCAC
T
GGCTACCTGAGCATAGTGTGGAAGACGCTGGCCCGCGCCTGGGCTGGGCTCGAGCAGCTG
CCTGTGGTG
TTTGAGGATGTGGTGCAGCACCAGGCCACCATCCTGCCCAAGACTGGGAC
AGTGTCCTTGGAGGTACGGC
TCCTGGAGGCCACCGGTGCCTTCGAGGTGTCAGAGAACG
GCAACCTGGTAGTGAGTGGGAAGGTGTACCA
GTGGGATGACCCTGACCCCAGGCTCTTC
GACCACCCGGAAAGTCCCCACCCCAATTCCCCACGGAGTCCC
CTCTTCCTGGCCCAGGC
AGAAGTTTACAAGGAGCTGCGTCTGCGTGGCTACGACTACGGCCCTCATTTCC
AGGGCA
TCCTGGAGGCCAGCCTGGAAGGTGACTCGGGGAGGCTGCTGTGGAAGGATAACTGGGTGA
GCTT
CATGGACACCATGCTGCAGATGTCCATCCTGGGCTCGGCCAAGCACGGCCTGTAC
CTACCCACCCGTGTC
ACCGCCATCCACATCGACCCTGCCACCCACAGGCAGAAGCTGTA
CACACTGCAGGACAAGGCCCAAGTGG
CTGACGTGGTGGTGAGCAGGTGGCCGAGGGTCA
CAGTGGCGGGAGGCGTCCACATCTCCGGGCTCCACAC
TGAGTCGGCCCCGCGGCGGCAC
GAGGAGCAGCAGGTGCCCATCCTGGAGAAGTTTTGCTTCACTCCCCAC
ACGGAGGAGGG
GTGCCTGTCTGAGCACGCTGCCCTCGAGGAGGAGCTGCAACTGTGCAAGGGGCTGGTCG
AGGCACTCGAGACCAAGGTGACCCAGCAGGGGCTGAAGATGGTGGTGCCGGACTGGACGG
GGCCCAGATC
CCCCCGGGACCCCTCACAGCAGGAACTGCCCCGGCTGTTGTCGGCTGCC
TGCAGGCTTCAGCTCAACGGG
AACCTGCAGCTGGAGCTGGCGCAGGTGCTGGCCCAGGA
GAGGCCCAAGCTGCCAGAGGACCCTCTGCTCA
GCGGCCTCCTGGACTCCCCGGCACTCA
AGGCCTGCCTGGACACTGCCGTGGAGAACATGCCCAGCCTGAA
GATGAAGGTGGTGGAG
GTGCTGGCCGGCCACGGTCACCTGTATTCCCGCATCCCAGGCCTGCTCAGCCCC
CATCC
CCTGCTGCAGCTGAGCTACACGGCCACCGACCGCCACCCCCAGGCCCTGGAGGCTGCCCA
GGCCG
AGCTGCAGCAGCACGACGTTGCCCAGGGCCAGTGGGATCCCGCAGACCCTGCCC
CCAGCGCCCTGGGCAG
CGCGGACCTCCTGGTGTGCAACTGTGCTGTGGCTGCCCTCGGG
GACCCGGCCTCAGCTCTCAGCAACATG
GTGGCTGCCCTGAGAGAAGGGGGCTTTCTGCT
CCTGCACACACTGCTCCGGGGGCACCCTCGGGACATCG
TGGCCTTCCTCACCTCCACTG
AGCCGCAGTATGGCCAGGGCATCCTGAGCCAGGACGCGTGGGAGAGCCT
CTTCTCCAGG
GTGTCGCTGCGCCTGGTGGGCCTGAAGAAGTCCTTCTACGGCGCCACGCTCTTCCTGTGC

CGCCGGCCCACCCCGCAGGACAGCCCCATCTTCCTGCCGGTGGACGATACCAGCTTCCG
CTGGGTGGAGT
CTCTGAAGGGCATCCTGGCTGACGAAGACTCTTCCCGGCCTGTGTGGC
TGAAGGCCATCAACTGTGCCAC
CTCGGGCGTGGTGGGCTTGGTGAACTGTCTCCGCCGA
GAGCCCGGCGGAACCGTCCGGTGTGTGCTGCTC
TCCAACCTCAGCAGCACCTCCCACGT
CCCGGAGGTGGACCCGGGCTCCGCAGAACTGCAGAAGGTGTTGC
AGGGAGACCTGGTGA
TGAACGTCTACCGCGACGGGGCCTGGGGGGTTTTCCGCCACTTCCTGCTGGAGGA
CAAG
CCTGAGGAGCCGACGGCACATGCCTTTGTGAGCACCCTCACCCGGGGGGACCTGTCCTCC
ATCCGC
TGGGTCTGCTCCTCGCTGCGCCATGCCCAGCCCACCTGCCCTGGCGCCCAGCT
CTGCACGGTCTACTACG
CCTCCCTCAACTTCCGCGACATCATGCTGGCCACTGGCAAGC
TGTCCCCTGATGCCATCCCAGGGAAGTG
GACCTCCCAGGACAGCCTGCTAGGTATGGAG
TTCTCGGGCCGAGACGCCAGCGGCAAGCGTGTGATGGGA
CTGGTGCCTGCCAAGGGCCT
GGCCACCTCTGTCCTGCTGTCACCGGACTTCCTCTGGGATGTGCCTTCCA
ACTGGACGC
TGGAGGAGGCGGCCTCGGTGCCTGTCGTCTACAGCACGGCCTACTACGCGCTGGTGGTGC
G
TGGGCGGGTGCGCCCCGGGGAGACGCTGCTCATCCACTCGGGCTCGGGCGGCGTGGGC
CAGGCCGCCATC
GCCATCGCCCTCAGTCTGGGCTGCCGCGTCTTCACCACCGTGGGGTC
GGCTGAGAAGCGGGCGTACCTCC
AGGCCAGGTTCCCCCAGCTCGACAGCACCAGCTTCG
CCAACTCCCGGGACACATCCTTCGAGCAGCATGT
GCTGTGGCACACGGGCGGGAAGGGC
GTTGACCTGGTCTTGAACTCCTTGGCGGAAGAGAAGCTGCAGGCC
AGCGTGAGGTGCTT
CGGTACGCACGGTCGCTTCCTGGAAATTGGCAAATTCGACCTTTCTCAGAACCACC
CGC
TCGGCATGGCTATCTTCCTGAAGAACGTGACATTCCACGGGGTCCTACTGGATGCGTTCT
TCAACGA
GAGCAGTGCTGACTGGCGGGAGGTGTGGGCGCTTGTCGAGGCCGCCATCCGG
GATGGGGTGGTACGGCCC
CTCAAGTGCACGGTGTTCCATGGGGCCCAGGTGGAGGACGC
CTTCCGCTACATGGCCCAAGGGAAGCACA
TTGGCAAAGTCGTCGTGCAGGTGCTTGCGG
AGGAGCCGGCAGTGCTGAAGGGGGCCAAACCCAAGCTGAT
GTCGGCCATCTCCAAGACC
TTCTGCCCGGCCCACAAGAGCTACATCATCGCTGGTGGTCTGGGTGGCTTC
GGCCTGGA
GTTGGCGCAGTGGCTGATACAGCGTGGGGTGCAGAAGCTCGTGTTGACTTCTCGCTCCGG
GA
TCCGGACAGGCTACCAGGCCAAGCAGGTCCGCCGGTGGAGGCGCCAGGGGCTACAGG
TGCAGGTGTCCAC
CAGCAACATCAGCTCACTGGAGGGGGCCCGGGGCCTCATTGCCGAG
GCGGCGCAGCTTGGGCCCGTGGGG
GGCGTCTTCAACCTGGCCGTGGTCTTGAGAGATGG
CTTGCTGGAGAACCAGACCCCAGAGTTCTTCCAGG
ACGTCTGCAAGCCCAAGTACAGCG
GCACCCTGAACCTGGACAGGGTGACCCGAGAGGCGTGCCCTGAGCT
GGACTACTTTGTG
GTCTTCTCCTCTGTGAGCTGCGGGCGTGGCAATGCGGGACAGAGCAACTACGGCTTT
GC
CAATTCCGCCATGGAGCGTATCTGTGAGAAACGCCGGCACGAAGGCCTCCCAGGCCTGGC
CGTGCAGT
GGGGCGCCATCGGCACCGTGGGCATTTTGGTGGAGACGATGAGCACCAACG
ACACGATCGTCAGTGGCAC
GCTGCCCACGCGCATTGGCGTCCTTGGCCTGGAGGTGCTG
GACCTCTTCCTGAACCAGCCCCACATGGTC
CTGAGCAGCTTTGTGCTGGCTGAGAAGGC
TGCGGCCTATAGGGACAGGGACAGCCAGCGGGACCTGGTGG
AGGCCGTGGCACACATCC
TGGGCATCCGCGACTTGGCTGCTGTCAACCTGGGCGGCTCACTGGCGGACCT
GGGCCTG
GACTCGCTCATGAGCGCGCCGGTGCGCCAGACGCTGGAGCGTGAGCTCAACCTGGTGCTG
TCC
GTGCGCGAGGTGCGGCAACTCACGCTCCGGAAACTGCAGGAGCTGTCCTCAAAGGC
GGATGAAGCCAGCG
AGCTGGCATGCCCCACGCCCAAGGAGGATGGTCTGGCCCAGCAGC
AGACTCAGCTGAACCTGCGCTCCCT
GCTGGTGAAACCGGAGGGCCCCACCCTGATGCGG
CTCAACTCCGTGCAGAGCTCGGAGCGGCCCCTGTTC
CTGGTGCACCCAATCGAGGCTAC
CACCGTGTTCCACAGCCTCGGTCCCGGTCTCAGCATCCCCACCTATG
GCCTGCAGTGCA
CCCCGGCTGCGCCCCTTGACAGCATCCACAGCCTGGCTGCCTACTACATCGACTGCAT
C
AGGCAGGTGCAGCCCGAGGGCCCCTACCGCGTGGCCGGCTACTCCTACGGGGCCTGCGTG
GCCTTTGAA
ATGTGCTCCCAGCTGCAGGCCCAGCAGAGCCCAGCCCCCACCCACAACAG
CCTCTTCCTGTTCGACGGCT
CGCCCACCTACGTACTGGCCTACACCCAGAGCTACCGGG
CAAAGCTGACCCCAGGCTGTAAGGCTGAGGC
TGAGACGGAGGCCATATGCTTCTTCGTG
CAGCAGTTCACGGACATGGAGCACAACAGGGTGCTGGAGGCG
CTGCTGCCGCTGAAGGG
CCTAGAGGAGCGTGTGGCAGCCGCCGTGGACCTGATCATCAAGAGCCACCAGG
GCCTGG
ACCGCCAGGAGCTGAGCTTTGCGGCCCGGTCCTTCTACTACAGGCTGCGTGCCGCTGACC
AGTA
TACACCCAAGGCCAAGTACAGTGGCAACGTGATGCTACTGCGGGCCAAGACGGGT
GGCCGCTACGGCGAG
GACCTGGGCGCGGACTACAACCTCTCCCAGGTATGCGACGGGAA
AGTATCCGTCCATATCATCGAGGGTG
ACCACCGCACGCTGCTGGAGGGCAGCGGCCTGG
AGTCCATCATCAGCATCATCCACAGCTCCCTGGCTGA
GCCACGTGTGAGTCGGGAGGGC
TAG

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
U26644

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_5_Locus:
17q25

# Macromolecular_Interacting_Partner_5_SNPs:
rs2228307; rs2229424; rs2228305; rs4485435; rs2229422; rs2229421; rs1140616; rs2228309; rs11550611; rs4246444; rs4246445; rs9905991; rs4969465; rs4969486; rs4075080; rs4502283; rs12937862; rs11077968; rs9891602; rs7215515; rs8066956; rs12949488; rs17848956; rs7222326; rs17848929; rs34019652; rs2228306; rs41283363; rs41283367; rs17848945; rs1140617; rs1140623; rs4363911; rs17848949; rs17848948; rs1140618; rs1140613; rs17855788; rs9890362; rs2229426; rs2229423; rs1140614; rs12946178; rs1140612; rs11550612; rs1140610; rs1140606; rs17848946; rs1140607; rs1140624; rs41283365; rs1140608; rs17848933; rs11550614; rs2229425; rs17848930; rs34179714; rs1140622; rs1140609; rs1140611; rs4547403; rs17848940; rs1140621; rs1140619; rs17855165; rs17848934; rs15324; rs1051138; rs34326255; rs17848939; rs17848941; rs17848925; rs41283371; rs17848958; rs17848963; rs17848931; rs17848955; rs17848942; rs17848961; rs17848959; rs34334536; rs9904054; rs17848924; rs17848962; rs9901600; rs41283361; rs17848927; rs17848950; rs4969466; rs34553245; rs17848960; rs12952709; rs9898060; rs41283369; rs12450902; rs17848951; rs17848935; rs17848926; rs9895384; rs17848937; rs17848944; rs17848932; rs8078234; rs10591316; rs35388606; rs17848954; rs9893404; rs11655220; rs12946373; rs34731893; rs17848953; rs11653745; rs11655217; rs11284316; rs34272050; rs34359605; rs10645484; rs7209621; rs34151210; rs34528587; rs1127678; rs11653003; rs11655646; rs11658040; rs12325930; rs4969485; rs6416857; rs6502050; rs6502051; rs7225637; rs8065606

# Macromolecular_Interacting_Partner_5_General_References:
7567999; 8022791; 7595075

# Macromolecular_Interacting_Partner_5_References:
11441127; 9594578

# Macromolecular_Interacting_Partner_6_ID:
7113

# Macromolecular_Interacting_Partner_6_Name:
Cytochrome c

# Macromolecular_Interacting_Partner_6_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_6_Gene_Name:
CYCS

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Cytochrome c
MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSYTAANKNKGIIW
GEDTLMEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNE

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
105

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
11749

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
10.16

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  binding
Function:  tetrapyrrole binding
Function:  heme binding
Function:  transporter activity
Function:  electron transporter activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Energy production and conversion 

# Macromolecular_Interacting_Partner_6_Specific_Function:
Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00034:Cytochrom_C

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
181242

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
CYC_HUMAN (P99999)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
CYCS

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
CYCS

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:19986

# Macromolecular_Interacting_Partner_6_PDB_ID:
1J3S

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>318 bp
ATGGGTGATGTTGAGAAAGGCAAGAAGATTTTTATTATGAAGTGTTCCCAGTGCCACACC
GTTGAAAAGGGAGGCAAGCACAAGACTGGGCCAAATCTCCATGGTCTCTTTGGGCGGAAG
ACAGGTCAGGCCCCTGGATACTCTTACACAGCCGCCAATAAGAACAAAGGCATCATCTGG
GGAGAGGATACACTGATGGAGTATTTGGAGAATCCCAAGAAGTACATCCCTGGAACAAAA
ATGATCTTTGTCGGCATTAAGAAGAAGGAAGAAAGGGCAGACTTAATAGCTTATCTCAAA
AAAGCTACTAATGAGTAA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
M22877

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_6_Locus:
7p15.2

# Macromolecular_Interacting_Partner_6_SNPs:
rs11769363; rs7810784; rs1861525; rs12700584; rs10215217; rs4719799; rs12700583; rs12700582; rs3846998; rs2107123; rs11548785; rs11548815; rs11548798; rs11548802; rs11548799; rs11548820; rs11548772; rs11548783; rs11548796; rs11548816; rs11548795; rs3211452; rs11548791; rs11548818; rs11548805; rs3211451; rs11548807; rs11548778; rs17851278; rs11548812; rs11548776; rs11548797; rs11548779; rs11548806; rs11548774; rs11548777; rs11427893; rs1137513; rs3173604; rs11548775; rs1060389; rs1137505; rs1137510; rs11548804; rs1801082; rs1060388; rs1137506; rs11548773; rs41275976; rs1137512; rs1137508; rs13310377; rs13310456; rs34522469; rs35325343; rs1137507; rs11548787; rs1137511; rs10230102; rs11548792; rs28376346; rs1137509; rs36061386; rs6967260; rs3040291; rs16873757; rs5882962; rs34102874; rs34500218; rs10238032; rs17150957; rs10278815; rs10279024; rs10951046; rs11489282; rs12700580; rs2107121; rs2107122; rs2391087; rs2717885; rs2717886

# Macromolecular_Interacting_Partner_6_General_References:
2849112; 12853948; 9515723

# Macromolecular_Interacting_Partner_6_References:
1326518; 166298; 5117522

# Macromolecular_Interacting_Partner_7_ID:
7803

# Macromolecular_Interacting_Partner_7_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_7_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_7_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_7_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_7_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_7_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_7_SNPs:
Not Available

# Macromolecular_Interacting_Partner_7_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_7_References:
7818804

# Macromolecular_Interacting_Partner_8_ID:
8724

# Macromolecular_Interacting_Partner_8_Name:
PGS1 protein

# Macromolecular_Interacting_Partner_8_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_8_Gene_Name:
PGS1

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>PGS1 protein
RVSMAVAAAAAAGPVFWRRLLGLLPGRPGLAALLGRLSDRLGRNRDRQRRRSPWLLLAPL
LSPAVPQVTSPPCCLCPEGVHRFQWIRNLVPEFGVSSSHVRVLSSPAEFFELMKVDCLES
TLEKSLQAKFPSNLKVSILLDFTRGSRGRKNSRTMLLPLLRRFPEQVRVSLFHTPHLRGL
LRLLIPERFNETIGLQHIKVYLFDNSVILSGANLSDSYFTNRQDRYVFLQDCAEIADFFT
ELVDAVGDVSLQLQGDDTVQVVDGMVHPYKGDRAEYCKAANKRVMDVINSARTRQQMLHA
QTFHSNSLLTQEDAAAAGDRRPAPDTWIYPLIQMKPFEIQIDEIVTETLLTEAERGAKVY
LTTGYFNLTQAYMDLVLGTRAEYQILLASPEVNGFFGPRGWPAPSQRPMCTSSDSSSVRC
AAWDSRSGSSFRSTGGGAGRSTPKVSSPGPGGPDCDRDGEPGPAAAASPGARAALPEVRC
GVLCHLRAAESPGEAVGEDGDSTDQELLLRTDRNGLDEDDRHGRGQLFQPRFSDDSSLGV
PASPCRDSMAEGQVCCQ

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
557

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
61141

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
7.20

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
 Function:  catalytic activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Lipid transport and metabolism

# Macromolecular_Interacting_Partner_8_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00614:PLDc

# Macromolecular_Interacting_Partner_8_Signals:
1-31

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
Q8IYK9_HUMAN (Q8IYK9)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
PGS1

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
PGS1

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:30029

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
BC035662

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_8_Locus:
17q25.3

# Macromolecular_Interacting_Partner_8_SNPs:
rs2292642; rs34088225; rs2376585; rs8071516; rs6501210; rs16971246; rs2138127; rs7208969; rs938350; rs2292644; rs11077363; rs4969143; rs7208596; rs4082919; rs4969178; rs4490057; rs2292640; rs938348; rs4969182; rs7212201; rs4969183; rs8071889; rs1540773; rs4129767; rs8072632; rs938351; rs4969186; rs2376583; rs3817295; rs9900564; rs8075131; rs4969142; rs1976704; rs938346; rs12453354; rs11077362; rs11871046; rs12453219; rs4969187; rs2090205; rs6501209; rs938347; rs11077361; rs6501208; rs4366775; rs11077364; rs16971105; rs3744216; rs2292643; rs4969179; rs4580257; rs4969144; rs2292641; rs11871028; rs3817294; rs7220865; rs17561950; rs2292645; rs4246438; rs16971107; rs4969184; rs12453603; rs17642548; rs7225914; rs11658146; rs12451109; rs16971236; rs9900792; rs12603140; rs8071552; rs7219215; rs12600422; rs3744217; rs1976703; rs12944051; rs938349; rs12450784; rs8071884; rs12601079; rs8073753; rs8072666; rs7225074; rs7221708; rs3744219; rs1968014; rs16971108; rs11867998; rs11657865; rs12453598; rs11657860; rs12150497; rs3826323; rs9900494; rs12450528; rs8077859; rs11656568; rs8069695; rs11657987; rs9901493; rs3744218; rs11651970; rs2063792; rs4969176; rs4969185; rs12452576; rs9901724; rs7219625; rs2376584; rs9901475; rs9891030; rs11653305; rs11655397; rs4969180; rs1814847; rs11653383; rs34833500; rs11449829; rs34937257; rs35046735; rs11268248; rs1139220; rs10977; rs1139218; rs1139223; rs10535561; rs12600914; rs1139221; rs10582335; rs3198068; rs4013606; rs7219674; rs12948394; rs35879509; rs11871647; rs8076277; rs35683208; rs7222111; rs10614866; rs34040603; rs9915500; rs10599133; rs4365353; rs34728397; rs34032688; rs12602206; rs8072820; rs10522107; rs34669930; rs3833108; rs4969141; rs28617527; rs12938284; rs8068516; rs1996229; rs4969177; rs8068866; rs12942811; rs35157694; rs5016938; rs34954607; rs35076134; rs12938572; rs35729867; rs12936112; rs9911769; rs10577356; rs28632046; rs12452647; rs5822252; rs36091608; rs12602692; rs4600525; rs10642898; rs7225217; rs12451715; rs12103714; rs7222619; rs12938571; rs5822251; rs4073934; rs10544232; rs35959287; rs35005537; rs12943030; rs7221930; rs9910613; rs12451056; rs35635587; rs35472026; rs35895090; rs35550812; rs12936764; rs8070806; rs34252361; rs4969181; rs7226256; rs5822253; rs36077709; rs4129768; rs35446090; rs11321162; rs3031603; rs33931168; rs35668021; rs10599132; rs12600411; rs10523020; rs12451791; rs34885272; rs9892707; rs34385648; rs4969145; rs34779407; rs12948949; rs3744220; rs12450500; rs10564375; rs34348117; rs12939451; rs9912930; rs34162262; rs34029669; rs5822250; rs11344447; rs34856467; rs12936797; rs4461143; rs9896278; rs34400166; rs12938809; rs12936808; rs4969174; rs11354596; rs12936558; rs4969175; rs35845066; rs34149030; rs1036990; rs12601655; rs12942703; rs1623869; rs1631200; rs1964450; rs2048754; rs2271613; rs3209030; rs34094807; rs35081093; rs35422926; rs35597902; rs35782078; rs35879621; rs35973257; rs36119275; rs4527079; rs4969172; rs4969188; rs589582; rs618324; rs618329; rs618842; rs6501213; rs650889; rs651806; rs666463; rs680027; rs690752; rs691061; rs691094; rs691113; rs691277; rs691328; rs691331; rs691342; rs691346; rs691362; rs691674; rs691680; rs7222563; rs8067560; rs8069521; rs8069689; rs8069809

# Macromolecular_Interacting_Partner_8_General_References:
12477932

# Macromolecular_Interacting_Partner_8_References:
Not Available

End of HMDB00126

Beginning of HMDB00127
# Accession_No:
HMDB00127

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-24 10:36:07

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
D-Glucuronic acid

# Description:
Glucuronic acid is a carboxylic acid that has the structure of a glucose molecule that has had its sixth carbon atom (of six total) oxidized. The salts of glucuronic acid are known as glucuronates. Glucuronic acid is highly soluble in water. In the animal body, glucuronic acid is often linked to poisonous substances to allow for subsequent elimination, and to hormones to allow for easier transport. These linkages involve O-glycosidic bonds. The process is known as glucuronidation, and the resulting substances are known as glucuronides (or glucuronosides). Glucuronidation uses UDP-glucuronic acid (glucuronic acid linked via a glycosidic bond to uridine diphosphate) as an intermediate. UDP-glucuronic acid is formed in the liver of all animals.

# Synonyms:
D-(+)-glucuronate; D-(+)-glucuronic acid; D-glucuronate; GCU; Glucosiduronate; Glucosiduronic acid; Glucuronate; Glucuronic acid; alpha-D-glucopyranuronic acid; alpha-D-glucuronic acid; delta-(+)-glucuronate; delta-(+)-glucuronic acid; delta-glucuronate; alpha-delta-glucopyranuronic acid; alpha-delta-glucuronic acid

# Chemical_IUPAC_Name:
(2S,3S,4S,5R,6S)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid

# Chemical_Formula:
C6H10O7

# Chemical_Structure:
tbl_chemical:::HMDB00127_ZOOM.png:::119283205528020832

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00127_THUMB.png:::119283205365469149

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Carbohydrates

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
1,2-diol; carboxylic acid; hemiacetal; heterocyclic compound; secondary alcohol

# Taxonomy_Biofunction:
Component of Chondroitin / Heparan sulfate biosynthesis; Component of Inositol phosphate metabolism; Component of Porphyrin and chlorophyll metabolism; Component of Starch and sucrose metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
194.04265

# Molecular_Weight_Avg:
194.13940

# Smiles_String_isomeric:
O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O

# Smiles_String_canonical:
OC1OC(C(O)C(O)C1O)C(O)=O

# KEGG_Compound_ID:
C00191

# BioCyc_ID:
GLUCURONATE

# PubChem_CID:
444791

# PubChem_SID:
10299584; 11110328; 11533714; 16878122; 3491; 821935; 821942; 821958; 821965; 828581; 828591; 830700; 837056; 837069

# OMIM_ID:
100675; 260800; 269920; 604369

# Metagene_ID:
Not Available

# BiGG_ID:
34196

# Wikipedia_ID:
GCU

# METLIN_ID:
161

# Ref_ID:
7193539; 7769794; 5755643; 962850; 734701; 1352222; 6848561; 2026685; 16598814; 6470139; 2758129; 1430236

# ChEBI_ID:
35182

# CAS_Registry_Number:
6556-12-3

# InChI:
InChI=1/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6-/m0/s1

# Synthesis_Reference:
 Journal of Molecular Catalysis A: Chemical  (2003),  191(1),  87-92

# Melting_Point:
143-144 oC

# Melting_Point_predicted:
109.2 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
485 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
1000 mg/mL at 25 oC [MEYLAN,WM et al. (1996)]; 295.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
-2.57 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-2 [Predicted by PubChem via XLOGP]; -2.30 [Predicted by ALOGPS]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::1166049820.pdf:::260024634068203>>>tbl_chemical:::1166049843.html:::282833490732642

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::1166049851.mol:::298738917642611

# SDF_File_[Text]:
tbl_chemical:::HMDB00127.sdf:::119283204989621992

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00127.pdb:::119283205227382844

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::050124_P00_07_IS_1DP_presat_expanded_2.gif:::114460751241896867

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::050124_P00_07_IS_1DP_presat.zip:::1175124337710439948

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050124_P00_07_IS_1DP_Assigned.png:::117389258541271108

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::050124_P00_07_IS_1DC_111.jpg:::114168392151490695

# C_NMR_FIDS_Spectra:
tbl_cnmr:::050124_P00_07_IS_1DC_111.zip:::114168392145870701

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::050124_P00_07_IS_1DC_111_Assigned.jpg:::116058412633279784

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050124_P00_07_IS_2DHSQC_404.jpg:::114617995507553123

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050124_P00_07_IS_2DHSQC_404.zip:::114617995508481804

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050124_P00_07_IS_2DHSQC_404_Assigned.jpg:::116058415240947364

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Glucuronic acid.gif:::1132732111703728407

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00127_peaks.txt:::1156309562719931174

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Glucuronic acid_C.gif:::1132737692658801084

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00127_peaks.txt:::1156310752765499626

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00127.png:::1165434252487306304; Medium Energy:tbl_ms:::HMDB00127.png:::116543412275869214; High Energy:tbl_ms:::HMDB00127.png:::1165434166672677891

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP); endoplasmic reticulum; lysosome

# Tissue_Location:
Liver

# deuterated:
No

# Biofluid_Location:
Bile; Blood; Urine

# Concentration_[Normal]:
Urine	33.8 +/- 21.0	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	2026685
Urine	5.9	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	5755643
Urine	55.8	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	2758129
Urine	30.5	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	5755643
Blood	165.0 +/- 32.0	uM	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	165.0 +/- 23.0	uM	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Not Available

# Pathway_Names:
Prostaglandin and leukotriene metabolism;Glutathione metabolism;Pyruvate metabolism

# Pathway_Images:
;;

# KEGG_Images:
map0059;map00480;map00620

# Pathway_Graphs:
;;

# Pathway_SBMLs:
;;

# Metabolic_Enzyme_1_ID:
6087

# Metabolic_Enzyme_1_Name:
Leukotriene C4 synthase

# Metabolic_Enzyme_1_Synonyms:
Leukotriene-C(4synthase; LTC4 synthase

# Metabolic_Enzyme_1_Gene_Name:
LTC4S

# Metabolic_Enzyme_1_Protein_Sequence:
>Leukotriene C4 synthase
MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYF
PLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVA
LAALGLLAHFLPAALRAALLGRLRTLLPWA

# Metabolic_Enzyme_1_Number_of_Residues:
150

# Metabolic_Enzyme_1_Molecular_Weight:
16567

# Metabolic_Enzyme_1_Theoretical_pI:
10.40

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme activator activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  organic acid metabolism
Process:  carboxylic acid metabolism
Process:  fatty acid metabolism
Process:  icosanoid metabolism
Process:  leukotriene metabolism
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4

# Metabolic_Enzyme_1_Pathway:
map00590  Prostaglandin and leukotriene metabolism

# Metabolic_Enzyme_1_Reaction:
leukotriene C4 = leukotriene A4 + glutathione

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01124:MAPEG

# Metabolic_Enzyme_1_Signals:
1-23

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 4.4.1.20

# Metabolic_Enzyme_1_GenBank_ID_Protein:
520485

# Metabolic_Enzyme_1_SwissProt_ID:
LTC4S_HUMAN (Q16873)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
LTC4S

# Metabolic_Enzyme_1_Geneatlas_id:
LTC4S

# Metabolic_Enzyme_1_hgnc_id:
HGNC:6719

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Membrane; multi-pass membrane protein

# Metabolic_Enzyme_1_Gene_Sequence:
>453 bp
ATGAAGGACGAGGTAGCTCTACTGGCTGCTGTCACCCTCCTGGGAGTCCTGCTGCAAGCC
TACTTCTCCCTGCAGGTGATCTCGGCGCGCAGGGCCTTCCGCGTGTCGCCGCCGCTCACC
ACCGGCCCACCCGAGTTCGAGCGCGTCTACCGAGCCCAGGTGAACTGCAGCGAGTACTTC
CCGCTGTTCCTCGCCACGCTCTGGGTCGCCGGCATCTTCTTTCATGAAGGGGCGGCGGCC
CTGTGCGGCCTGGTCTACCTGTTCGCGCGCCTCCGCTACTTCCAGGGCTACGCGCGCTCC
GCGCAGCTCAGGCTGGCACCGCTGTACGCGAGCGCGCGCGCCCTCTGGCTGCTGGTGGCG
CTGGCTGCGCTCGGCCTGCTCGCCCACTTCCTCCCGGCCGCGCTGCGCGCCGCGCTCCTC
GGACGGCTCCGGACGCTGCTGCCGTGGGCCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U09353

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_1_Locus:
5q35

# Metabolic_Enzyme_1_SNPs:
rs272431; rs2306795; rs730012; rs3776944; rs11541078; rs13162195; rs13163304; rs11541077; rs524308; rs34011389; rs523487; rs524372; rs35643466; rs7706693; rs1043193; rs12518252; rs12522926; rs12652934; rs12658721; rs12658766; rs1469020; rs1469021; rs1552436; rs166624; rs187294; rs190629; rs190630; rs190631; rs2291417; rs2291418; rs2431117; rs272439; rs272440; rs28365147; rs28365148; rs3756614; rs514952; rs515003; rs530258; rs539812; rs551693; rs552607; rs562457; rs6883116

# Metabolic_Enzyme_1_General_References:
8052639; 7937884; 8626689; 8898379; 8446623

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6088

# Metabolic_Enzyme_2_Name:
Glutathione S-transferase Mu 2

# Metabolic_Enzyme_2_Synonyms:
GSTM2-2; GST class-mu 2

# Metabolic_Enzyme_2_Gene_Name:
GSTM2

# Metabolic_Enzyme_2_Protein_Sequence:
>Glutathione Stransferase Mu 2
MPMTLGYWNIRGLAHSIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGTHKITQSNAILRYIARKHNLCGESEKEQIREDILENQFMDSRMQLAKLCYDPDF
EKLKPEYLQALPEMLKLYSQFLGKQPWFLGDKITFVDFIAYDVLERNQVFEPSCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPRPVFTKMAVWGNK

# Metabolic_Enzyme_2_Number_of_Residues:
218

# Metabolic_Enzyme_2_Molecular_Weight:
25745

# Metabolic_Enzyme_2_Theoretical_pI:
6.29

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  glutathione transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

# Metabolic_Enzyme_2_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_2_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Metabolic_Enzyme_2_Signals:
1-16

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_2_GenBank_ID_Protein:
183301

# Metabolic_Enzyme_2_SwissProt_ID:
GSTM2_HUMAN (P28161)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
GSTM2

# Metabolic_Enzyme_2_Geneatlas_id:
GSTM2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:4634

# Metabolic_Enzyme_2_PDB_ID:
1XW5

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>657 bp
ATGCCCATGACACTGGGGTACTGGAACATCCGCGGGCTGGCCCATTCCATCCGCCTGCTC
CTGGAATACACAGACTCAAGCTACGAGGAAAAGAAGTACACGATGGGGGACGCTCCTGAT
TATGACAGAAGCCAGTGGCTGAATGAAAAATTCAAGCTGGGCCTGGACTTTCCCAATCTG
CCCTACTTGATTGATGGGACTCACAAGATCACCCAGAGCAATGCCATCCTGCGGTACATT
GCCCGCAAGCACAACCTGTGCGGGGAATCAGAAAAGGAGCAGATTCGCGAAGACATTTTG
GAGAACCAGTTTATGGACAGCCGTATGCAGCTGGCCAAACTCTGCTATGACCCAGATTTT
GAGAAACTGAAACCAGAATACCTGCAGGCACTCCCTGAAATGCTGAAGCTCTACTCACAG
TTTCTGGGGAAGCAGCCATGGTTTCTTGGGGACAAGATCACCTTTGTGGATTTCATCGCT
TATGATGTCCTTGAGAGAAACCAAGTATTTGAGCCCAGCTGCCTGGATGCCTTCCCAAAC
CTGAAGGACTTCATCTCCCGATTTGAGGGCTTGGAGAAGATCTCTGCCTACATGAAGTCC
AGCCGCTTCCTCCCAAGACCTGTGTTCACAAAGATGGCTGTCTGGGGCAACAAGTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M63509

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_2_Locus:
1p13.3

# Metabolic_Enzyme_2_SNPs:
rs592792; rs1805358; rs655315; rs574344; rs402505; rs3861917; rs530021; rs428434; rs1149177; rs1149178; rs687643; rs430454; rs3819350; rs676828; rs673151; rs2073483; rs655323; rs625456; rs638820; rs473682; rs641065; rs35961720; rs1056799; rs11540636; rs1140964; rs403294; rs2229047; rs1056800; rs4147574; rs28361909; rs403337; rs7553408; rs756635; rs35533907; rs28623664; rs4970770; rs34285855; rs35289531; rs41283500; rs430656; rs4518929; rs2236862; rs35541092; rs34006015; rs12024479; rs12090060; rs12732862; rs17024655; rs2011158; rs3211193; rs521999; rs535537; rs650985; rs670439

# Metabolic_Enzyme_2_General_References:
2034681; 8373352; 8182750

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6089

# Metabolic_Enzyme_3_Name:
Glutathione peroxidase 7 precursor

# Metabolic_Enzyme_3_Synonyms:
CL683

# Metabolic_Enzyme_3_Gene_Name:
GPX7

# Metabolic_Enzyme_3_Protein_Sequence:
>Glutathione peroxidase 7 precursor
MVAATVAAAWLLLWAAACAQQEQDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFT
DQHYRALQQLQRDLGPHHFNVLAFPCNQFGQQEPDSNKEIESFARRTYSVSFPMFSKIAV
TGTGAHPAFKYLAQTSGKEPTWNFWKYLVAPDGKVVGAWDPTVSVEEVRPQITALVRKLI
LLKREDL

# Metabolic_Enzyme_3_Number_of_Residues:
187

# Metabolic_Enzyme_3_Molecular_Weight:
20996

# Metabolic_Enzyme_3_Theoretical_pI:
8.46

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  glutathione peroxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_3_Specific_Function:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O

# Metabolic_Enzyme_3_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_3_Reaction:
2 glutathione + H2O2 = glutathione disulfide + 2 H2O

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00255:GSHPx

# Metabolic_Enzyme_3_Signals:
1-19

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.11.1.9

# Metabolic_Enzyme_3_GenBank_ID_Protein:
25990366

# Metabolic_Enzyme_3_SwissProt_ID:
GPX7_HUMAN (Q96SL4)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
GPX7

# Metabolic_Enzyme_3_Geneatlas_id:
GPX7

# Metabolic_Enzyme_3_hgnc_id:
HGNC:4559

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Secreted protein (Potential)

# Metabolic_Enzyme_3_Gene_Sequence:
>564 bp
ATGGTGGCGGCGACGGTGGCAGCGGCGTGGCTGCTCCTGTGGGCTGCGGCCTGCGCGCAG
CAGGAGCAGGACTTCTACGACTTCAAGGCGGTCAACATCCGGGGCAAACTGGTGTCGCTG
GAGAAGTACCGCGGATCGGTGTCCCTGGTGGTGAATGTGGCCAGCGAGTGCGGCTTCACA
GACCAGCACTACCGAGCCCTGCAGCAGCTGCAGCGAGACCTGGGCCCCCACCACTTTAAC
GTGCTCGCCTTCCCCTGCAACCAGTTTGGCCAACAGGAGCCTGACAGCAACAAGGAGATT
GAGAGCTTTGCCCGCCGCACCTACAGTGTCTCATTCCCCATGTTTAGCAAGATTGCAGTC
ACCGGTACTGGTGCCCATCCTGCCTTCAAGTACCTGGCCCAGACTTCTGGGAAGGAGCCC
ACCTGGAACTTCTGGAAGTACCTAGTAGCCCCAGATGGAAAGGTGGTAGGGGCTTGGGAC
CCAACTGTGTCAGTGGAGGAGGTCAGACCCCAGATCACAGCGCTCGTGAGGAAGCTCATC
CTACTGAAGCGAGAAGACTTATAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
AF320068

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_3_Locus:
1p32

# Metabolic_Enzyme_3_SNPs:
rs1970951; rs11205977; rs1047635; rs34559218; rs1047619; rs35180794; rs35091626; rs1970950; rs3753754; rs1970949; rs3753753; rs946154; rs11590859; rs946155; rs5774123; rs34134045; rs34019243; rs12089784; rs35226390; rs34180910; rs34716005; rs34098557; rs3753755; rs34766522; rs12122956; rs35947490; rs36040857; rs35528996; rs34925052; rs35128274; rs35455603; rs6588431; rs11810754; rs1416093; rs34908366; rs1416094; rs34001794; rs35915506; rs4451503; rs35236738; rs34917710; rs11809445; rs34349442; rs34024818; rs12072163; rs35263197; rs34561499; rs34827441; rs35607140; rs12733653; rs35705883; rs35883827; rs35232415; rs12728439; rs35008200; rs12046620; rs35637052; rs12724635; rs10158955; rs1097234; rs12039202; rs1338370; rs1416091; rs17107332; rs34087138; rs6588432; rs6671552; rs6682886; rs6683347; rs6701434; rs7527068; rs7529595; rs835337; rs835338; rs835339; rs835340; rs835341; rs835342

# Metabolic_Enzyme_3_General_References:
12975309

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
6090

# Metabolic_Enzyme_4_Name:
Epididymal secretory glutathione peroxidase precursor

# Metabolic_Enzyme_4_Synonyms:
Epididymis-specific glutathione peroxidase-like protein; EGLP

# Metabolic_Enzyme_4_Gene_Name:
GPX5

# Metabolic_Enzyme_4_Protein_Sequence:
>Epididymal secretory glutathione peroxidase precursor
MTTQLRVVHLLPLLLACFVQTSPKQEKMKMDCHKDEKGTIYDYEAIALNKNEYVSFKQYV
GKHILFVNVATYCGLTAQYPELNALQEELKPYGLVVLGFPCNQFGKQEPGDNKEILPGLK
YVRPGGGFVPSFQLFEKGDVNGEKEQKVFSFLKHSCPHPSEILGTFKSISWDPVKVHDIR
WNFEKFLVGPDGIPVMRWSHRATVSSVKTDILAYLKQFKTK

# Metabolic_Enzyme_4_Number_of_Residues:
221

# Metabolic_Enzyme_4_Molecular_Weight:
25203

# Metabolic_Enzyme_4_Theoretical_pI:
8.89

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  glutathione peroxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_4_Specific_Function:
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathionine peroxidase-like protective system against peroxide damage in sperm membrane lipids

# Metabolic_Enzyme_4_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_4_Reaction:
2 glutathione + H2O2 = glutathione disulfide + 2 H2O

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00255:GSHPx

# Metabolic_Enzyme_4_Signals:
1-21

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.11.1.9

# Metabolic_Enzyme_4_GenBank_ID_Protein:
3288455

# Metabolic_Enzyme_4_SwissProt_ID:
GPX5_HUMAN (O75715)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
GPX5

# Metabolic_Enzyme_4_Geneatlas_id:
GPX5

# Metabolic_Enzyme_4_hgnc_id:
HGNC:4557

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_4_Gene_Sequence:
>666 bp
ATGACTACACAGTTAAGGGTCGTCCATCTGCTTCCCCTTCTCCTAGCCTGCTTTGTGCAA
ACAAGTCCCAAGCAGGAGAAGATGAAGATGGATTGCCACAAAGACGAGAAAGGCACCATC
TATGACTATGAGGCCATCGCACTTAATAAGAATGAATATGTTTCCTTCAAGCAGTATGTG
GGCAAGCACATCCTCTTCGTCAACGTGGCCACCTACTGTGGTCTGACAGCGCAATATCCT
GAACTAAATGCACTCCAGGAGGAGCTGAAGCCCTATGGTCTAGTTGTGTTGGGCTTTCCC
TGCAACCAATTTGGAAAGCAAGAACCAGGAGATAACAAAGAGATTCTTCCTGGGCTCAAG
TATGTCCGTCCAGGGGGAGGATTTGTACCTAGTTTCCAGCTTTTTGAGAAAGGGGATGTG
AATGGTGAAAAAGAACAGAAAGTCTTCAGTTTCTTGAAGCACTCCTGTCCTCATCCCTCT
GAGATTTTGGGCACATTCAAATCTATATCCTGGGACCCTGTAAAGGTCCATGACATCCGT
TGGAACTTTGAAAAGTTCCTGGTGGGGCCTGATGGAATCCCTGTCATGCGCTGGTCCCAC
CGGGCTACGGTCAGCTCAGTCAAGACAGACATCCTGGCGTACTTGAAGCAATTCAAAACC
AAATAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AJ005277

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_4_Locus:
6p22.1

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
9639555; 14574404

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
6091

# Metabolic_Enzyme_5_Name:
Glutathione S-transferase Mu 1

# Metabolic_Enzyme_5_Synonyms:
GSTM1-1; GST class-mu 1; GSTM1a-1a; GSTM1b-1b; HB subunit 4; GTH4

# Metabolic_Enzyme_5_Gene_Name:
GSTM1

# Metabolic_Enzyme_5_Protein_Sequence:
>Glutathione Stransferase Mu 1
MPMILGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQTMDNHMQLGMICYNPEF
EKLKPKYLEELPEKLKLYSEFLGKRPWFAGNKITFVDFLVYDVLDLHRIFEPKCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPRPVFSKMAVWGNK

# Metabolic_Enzyme_5_Number_of_Residues:
218

# Metabolic_Enzyme_5_Molecular_Weight:
25712

# Metabolic_Enzyme_5_Theoretical_pI:
6.67

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  glutathione transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

# Metabolic_Enzyme_5_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_5_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Metabolic_Enzyme_5_Signals:
1-16

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_5_GenBank_ID_Protein:
31924

# Metabolic_Enzyme_5_SwissProt_ID:
GSTM1_HUMAN (P09488)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
GSTM1

# Metabolic_Enzyme_5_Geneatlas_id:
GSTM1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:4632

# Metabolic_Enzyme_5_PDB_ID:
1XWK

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>657 bp
ATGCCCATGATACTGGGGTACTGGGACATCCGCGGGCTGGCCCACGCCATCCGCCTGCTC
CTGGAATACACAGACTCAAGCTATGAGGAAAAGAAGTACACGATGGGGGACGCTCCTGAT
TATGACAGAAGCCAGTGGCTGAATGAAAAATTCAAGCTGGGCCTGGACTTTCCCAATCTG
CCCTACTTGATTGATGGGGCTCACAAGATCACCCAGAGCAACGCCATCTTGTGCTACATT
GCCCGCAAGCACAACCTGTGTGGGGAGACAGAAGAGGAGAAGATTCGTGTGGACATTTTG
GAGAACCAGACCATGGACAACCATATGCAGCTGGGCATGATCTGCTACAATCCAGAATTT
GAGAAACTGAAGCCAAAGTACTTGGAGGAACTCCCTGAAAAGCTAAAGCTCTACTCAGAG
TTTCTGGGGAAGCGGCCATGGTTTGCAGGAAACAAGATCACTTTTGTAGATTTTCTCGTC
TATGATGTCCTTGACCTCCACCGTATATTTGAGCCCAAGTGCTTGGACGCCTTCCCAAAT
CTGAAGGACTTCATCTCCCGCTTTGAGGGCTTGGAGAAGATCTCTGCCTACATGAAGTCC
AGCCGCTTCCTCCCAAGACCTGTGTTCTCAAAGATGGCTGTCTGGGGCAACAAGTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X08020

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_5_Locus:
1p13.3

# Metabolic_Enzyme_5_SNPs:
rs1056806; rs2071487; rs1065410; rs10857796; rs737497; rs756637; rs4147567; rs3815029; rs412302; rs412543; rs3815026; rs421547; rs6689902; rs1065411; rs12068997; rs12562055; rs4147565; rs11101983; rs10712361; rs4147564; rs6674567; rs2239892; rs4147566; rs448934; rs5776994; rs35658836; rs10857795; rs4147568; rs12729297; rs12097277; rs36209760; rs4147562; rs36209754; rs3951465; rs36209092; rs36209417; rs36210407; rs36209090; rs36209419; rs679005; rs36209756; rs28549287; rs36209759; rs423033; rs679529; rs679035; rs36210086; rs36208870; rs36209762; rs36210404; rs4025934; rs36209093; rs1634252; rs36210087; rs4147563; rs36210085; rs36210091; rs36209761; rs36208868; rs36209091; rs36210406; rs4147561; rs36210084; rs36210089; rs36209757; rs36210093; rs36209763; rs4025935; rs36209758; rs36210090; rs36208869; rs36209089; rs36210410

# Metabolic_Enzyme_5_General_References:
3419925; 3174634; 8471052; 2362832; 8317488; 2110160; 3864155; 3979555; 1846734; 1420361; 11271497; 9930979

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
6092

# Metabolic_Enzyme_6_Name:
Hydroxyacylglutathione hydrolase

# Metabolic_Enzyme_6_Synonyms:
Glyoxalase II; GLX II

# Metabolic_Enzyme_6_Gene_Name:
HAGH

# Metabolic_Enzyme_6_Protein_Sequence:
>Hydroxyacylglutathione hydrolase
MKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHA
GGNEKLVKLESGLKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVS
KPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNL
KFARHVEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETD
PVTTMRAVRREKDQFKMPRD

# Metabolic_Enzyme_6_Number_of_Residues:
260

# Metabolic_Enzyme_6_Molecular_Weight:
28860

# Metabolic_Enzyme_6_Theoretical_pI:
7.36

# Metabolic_Enzyme_6_GO_Classification:
Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid

# Metabolic_Enzyme_6_Pathway:
map00620  Pyruvate metabolism

# Metabolic_Enzyme_6_Reaction:
S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00753:Lactamase_B

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.1.2.6

# Metabolic_Enzyme_6_GenBank_ID_Protein:
1237213

# Metabolic_Enzyme_6_SwissProt_ID:
GLO2_HUMAN (Q16775)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
HAGH

# Metabolic_Enzyme_6_Geneatlas_id:
HAGH

# Metabolic_Enzyme_6_hgnc_id:
HGNC:4805

# Metabolic_Enzyme_6_PDB_ID:
1QH3

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>783 bp
ATGAAGGTAGAGGTGCTGCCTGCCCTGACCGACAACTACATGTACCTGGTCATTGATGAT
GAGACCAAGGAGGCTGCCATTGTGGATCCGGTGCAGCCCCAGAAGGTCGTGGACGCGGCG
AGAAAGCACGGGGTGAAACTGACCACAGTGCTCACCACCCACCACCACTGGGACCATGCT
GGCGGGAATGAGAAACTGGTCAAGCTGGAGTCGGGACTGAAGGTGTACGGGGGTGACGAC
CGTATCGGGGCCCTGACTCACAAGATCACTCACCTGTCCACACTGCAGGTGGGGTCTCTG
AACGTCAAGTGCCTGGCGACCCCGTGCCACACTTCAGGACACATTTGTTACTTCGTGAGC
AAGCCCGGAGGCTCGGAGCCCCCTGCCGTGTTCACAGGTGACACCTTGTTTGTGGCTGGC
TGCGGGAAGTTCTATGAAGGGACTGCGGATGAGATGTGTAAAGCTCTGCTGGAGGTCTTG
GGCCGGCTCCCCCCGGACACAAGAGTCTACTGTGGCCACGAGTACACCATCAACAACCTC
AAGTTTGCACGCCACGTGGAGCCCGGCAATGCCGCCATCCGGGAGAAGCTGGCCTGGGCC
AAGGAGAAGTACAGCATCGGGGAGCCCACAGTGCCATCCACCCTGGCAGAGGAGTTTACC
TACAACCCCTTCATGAGAGTGAGGGAGAAGACGGTGCAGCAGCACGCAGGTGAGACGGAC
CCGGTGACCACCATGCGGGCCGTGCGCAGGGAGAAGGACCAGTTCAAGATGCCCCGGGAC
TGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
X90999

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_6_Locus:
16p13.3

# Metabolic_Enzyme_6_SNPs:
rs3760038; rs8056465; rs2437728; rs1657151; rs1657152; rs104843; rs3760039; rs3760034; rs1742412; rs3760035; rs3760041; rs1057071; rs11648072; rs1057070; rs3760037; rs9925264; rs2516314; rs4786635; rs1628812; rs2745199; rs8046750; rs1657109; rs7205570; rs1742445; rs2575357; rs344361; rs2268674; rs12597803; rs2268675; rs1742458; rs11860469; rs2076448; rs11859266; rs8045169; rs9937991; rs11859263; rs11248891; rs11646951; rs2268671; rs11248892; rs12597098; rs9928924; rs1742442; rs2076451; rs12719795; rs11641257; rs1657111; rs12595860; rs11865665; rs1657110; rs238680; rs238678; rs11866526; rs7192399; rs12596094; rs3785274; rs238679; rs11864471; rs9935687; rs2437731; rs2076450; rs2268669; rs11862094; rs9928472; rs2300641; rs11862755; rs12598216; rs1629534; rs11860201; rs10083731; rs2268670; rs2076454; rs2300642; rs11644716; rs12929489; rs2369385; rs11863390; rs7197435; rs1629513; rs2076452; rs1657108; rs2268673; rs7186249; rs1111687; rs9932450; rs2437730; rs1624387; rs1623452; rs1625344; rs1028590; rs1742430; rs11862061; rs1657106; rs1623562; rs1657107; rs2473467; rs2745198; rs1623559; rs17849371; rs11558513; rs12929029; rs3834553; rs3760040; rs28629422; rs28416063; rs4027459; rs35082047; rs3834554; rs10717039; rs4017982; rs3028424; rs34419509; rs34228180; rs1742411; rs34459147; rs149159; rs11862103; rs2076453; rs2262271; rs2268672; rs8059837; rs3993943; rs11367242; rs2575344; rs3216614; rs9928566; rs2268668; rs9937825; rs4027423; rs8059195; rs3993944; rs12596619; rs3028420; rs9938397; rs12103291; rs12103093; rs9928547; rs11639880; rs35223183; rs35926706; rs3993941; rs9652775; rs11648104; rs34684300; rs10678588; rs8059831; rs3993945; rs2076449; rs34743458; rs35216968; rs12446657; rs9928484; rs2076455; rs3993942; rs12596618; rs9652784; rs7191714; rs34207703; rs3028386; rs2076456; rs9925482; rs1657105; rs36119992; rs3028379; rs33941770; rs11390826; rs9933871; rs12102914; rs3993951; rs2179489; rs1742415; rs35567844; rs3993950; rs2473469; rs35509613; rs35956038; rs1065583; rs1065584; rs11641144; rs11645599; rs12325141; rs12325217; rs12325218; rs12325282; rs12920937; rs12929915; rs13166; rs13332303; rs1657097; rs1657098; rs1657150; rs171162; rs1742410; rs1742450; rs1742453; rs186938; rs238677; rs238682; rs238683; rs2575342; rs2745189; rs35148647; rs35813105; rs3743852; rs4100646; rs4405553; rs7189070; rs7190337; rs7190601; rs8047464; rs9652776; rs9652777; rs9652778; rs9652785; rs9652786; rs9925460; rs9926962

# Metabolic_Enzyme_6_General_References:
8550579; 11157797; 10508780

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
6005

# Metabolic_Enzyme_7_Name:
Gamma-glutamyltranspeptidase 1 precursor

# Metabolic_Enzyme_7_Synonyms:
Gamma- glutamyltransferase 1; GGT 1; CD224 antigen[Contains: Gamma- glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain]

# Metabolic_Enzyme_7_Gene_Name:
GGT1

# Metabolic_Enzyme_7_Protein_Sequence:
>Gammaglutamyltranspeptidase 1 precursor
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRD
GGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMFN
SSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALEN
KRTVIEQQPVLCEVFCRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKD
IQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSR
ESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISD
DTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNE
MDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTA
TALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTF
IAVVQAIVRTAGGWAAASDSRKGGEPAGY

# Metabolic_Enzyme_7_Number_of_Residues:
569

# Metabolic_Enzyme_7_Molecular_Weight:
61411

# Metabolic_Enzyme_7_Theoretical_pI:
7.14

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring amino-acyl groups
Function:  gamma-glutamyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive

# Metabolic_Enzyme_7_Pathway:
map00430  Taurine and hypotaurine metabolism;
 map00450  Selenoamino acid metabolism;
 map00460  Cyanoamino acid metabolism;
 map00480  Glutathione metabolism;
 map00590  Prostaglandin and leukotriene metabolism

# Metabolic_Enzyme_7_Reaction:
(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF01019:G_glu_transpept

# Metabolic_Enzyme_7_Signals:
1-30

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.3.2.2

# Metabolic_Enzyme_7_GenBank_ID_Protein:
183138

# Metabolic_Enzyme_7_SwissProt_ID:
GGT1_HUMAN (P19440)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
GGT1

# Metabolic_Enzyme_7_Geneatlas_id:
GGT1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:4250

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_7_Gene_Sequence:
>1710 bp
ATGAAGAAGAAGTTAGTGGTGCTGGGCCTGCTGGCCGTGGTCCTGGTGCTGGTCATTGTC
GGCCTCTGTCTCTGGCTGCCCTCAGCCTCCAAGGAACCTGACAACCATGTGTACACCAGG
GCTGCCGTGGCCGCGGATGCCAAGCAGTGCTCGAAGATTGGGAGGGATGCACTGCGGGAC
GGTGGCTCTGCGGTGGATGCAGCCATTGCAGCCCTGTTGTGTGTGGGGCTCATGAATGCC
CACAGCATGGGCATCGGGGGTGGCCTCTTCCTCACCATCTACAACAGCACCACACGAAAA
GCTGAGGTCATCAACGCCCGCGAGGTGGCCCCCAGGCTGGCCTTTGCCACCATGTTCAAC
AGCTCGGAGCAGTCCCAGAAGGGGGGGCTGTCGGTGGCGGTGCCTGGGGAGATCCGAGGC
TATGAGCTGGCACACCAGCGGCATGGGCGGCTGCCCTGGGCTCGCCTCTTCCAGCCCAGC
ATCCAGCTGGCCCGCCAGGGCTTCCCCGTGGGCAAGGGCTTGGCGGCAGCCCTGGAAAAC
AAGCGGACCGTCATCGAGCAGCAGCCTGTCTTGTGTGAGGTGTTCTGCCGGGATAGAAAG
GTGCTTCGGGAGGGGGAGAGACTGACCCTGCCGCAGCTGGCTGACACCTACGAGACGCTG
GCCATCGAGGGTGCCCAGGCCTTCTACAACGGCAGCCTCACGGCCCAGATTGTGAAGGAC
ATCCAGGCGGCCGGGGGCATTGTGACAGCTGAGGACCTGAACAACTACCGTGCTGAGCTG
ATCGAGCACCCGCTGAACATCAGCCTGGGAGACGCGGTGCTGTACATGCCCAGTGCGCCG
CTCAGCGGGCCCGTGCTGGCCCTCATCCTCAACATCCTCAAAGGGTACAACTTCTCCCGG
GAGAGCGTGGAGAGCCCCGAGCAGAAGGGCCTGACGTACCACCGCATCGTAGAGGCTTTC
CGGTTTGCCTACGCCAAGAGGACCCTGCTTGGGGACCCCAAGTTTGTGGATGTGACTGAG
GTGGTCCGCAACATGACCTCCGAGTTCTTCGCTGCCCAGCTCCGGGCCCAGATCTCTGAC
GACACCACTCACCCGATCTCCTACTACAAGCCCGAGTTCTACACGCCGGATGACGGGGGC
ACTGCTCACCTGTCTGTCGTCGCAGAGGACGGCAGTGCTGTGTCCGCCACCAGCACCATC
AACCTCTACTTTGGCTCCAAGGTCCGCTCCCCGGTCAGCGGGATCCTGTTCAATAATGAA
ATGGACGACTTCAGCTCTCCCAGCATCACCAACGAGTTTGGGGTACCCCCCTCACCTGCC
AATTTCATCCAGCCAGGGAAGCAGCCGCTCTCGTCCATGTGCCCGACGATCATGGTGGGC
CAGGACGGCCAGGTCCGGATGGTGGTGGGAGCTGCTGGGGGCACACAGATCACCACGGCC
ACTGCACTGGCCATCATCTACAACCTCTGGTTCGGCTATGACGTGAAGCGGGCCGTGGAG
GAGCCCCGGCTGCACAACCAGCTTCTGCCCAACGTCACGACAGTGGAGAGAAACATTGAC
CAGGCAGTGACTGCAGCCCTGGAGACCCGGCACCATCACACCCAGATCGCGTCCACCTTC
ATCGCTGTGGTGCAAGCCATCGTCCGCACGGCTGGTGGCTGGGCAGCTGCCTCGGACTCC
AGGAAAGGCGGGGAGCCTGCCGGCTACTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
J04131

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_7_Locus:
22q11.23

# Metabolic_Enzyme_7_SNPs:
rs2330837; rs3895576; rs2330838; rs2017869; rs2330795; rs2073398; rs9624507; rs2006092; rs6519520; rs5751901; rs6519519; rs7284489; rs3788375; rs7292010; rs5760495; rs4049889; rs2006094; rs5760494; rs2001180; rs6004192; rs5751905; rs5760493; rs2006227; rs9624506; rs2005589; rs4822516; rs5751904; rs2073397; rs5760492; rs2076999; rs3859862; rs2010657; rs2003757; rs16990490; rs8138050; rs4049918; rs9608300; rs2017188; rs1807629; rs2330797; rs4822517; rs6004195; rs7286626; rs3747117; rs5760491; rs2330805; rs9624510; rs743371; rs3876104; rs4820600; rs5751902; rs5760490; rs6004193; rs6004194; rs8135987; rs8139070; rs5751909; rs5751910; rs9306396; rs9612676; rs5760505; rs2330848; rs5760499; rs5760497; rs5760504; rs4049843; rs9680722; rs2330841; rs524033; rs11913233; rs9680724; rs4049855; rs380131; rs3934421; rs4822523; rs5760500; rs6004203; rs3901297; rs5760498; rs391837; rs5751908; rs9680612; rs3895577; rs4822520; rs4049869; rs3895575; rs7511507; rs7511598; rs389004; rs2236626; rs7285339; rs2330842; rs4049882; rs4049829; rs28621555; rs2330836; rs3966247; rs12159765; rs4049897; rs4049881; rs9612682; rs2330843; rs4049844; rs4049883; rs2330844; rs5751900; rs2330830; rs12169166; rs4049900; rs2330818; rs2330826; rs9624503; rs3966256; rs9612663; rs3966255; rs3895580; rs4049911; rs2877222; rs2330801; rs3033885; rs9624509; rs6004196; rs4049914; rs2330835; rs1832359; rs28509371; rs4049896; rs2298391; rs2330825; rs9624505; rs2877224; rs4049885; rs2330811; rs4049917; rs2330806; rs3876101; rs3887791; rs12484586; rs4049890; rs8139074; rs3895578; rs28550867; rs4049905; rs4049925; rs3966259; rs673673; rs753462; rs4049899; rs2330813; rs8138031; rs4049895; rs28605797; rs3966263; rs3876105; rs9612666; rs2330808; rs2330832; rs2076800; rs13057657; rs3033738; rs3966257; rs2330803; rs2330815; rs4049912; rs3033744; rs2330810; rs2330800; rs3895574; rs6004191; rs8137090; rs2330807; rs2330834; rs4049913; rs28449741; rs2330827; rs3966260; rs9624504; rs2330817; rs9612671; rs4049903; rs2877221; rs5751903; rs2330824; rs2079567; rs2330796; rs4049898; rs11913684; rs2877225; rs2330831; rs4049891; rs4049915; rs2330812; rs4049910; rs4049916; rs4049908; rs12106564; rs3876100; rs3859863; rs3032936; rs9624508; rs4049901; rs12163146; rs4049924; rs4049906; rs2330819; rs9612664; rs3788376; rs3895579; rs2330822; rs2330804; rs2330823; rs2077120; rs2089350; rs2330814; rs2006093; rs4049904; rs9608301; rs3865759; rs2330799; rs3966258; rs28566494; rs2330820; rs3876103; rs2330802; rs4049926; rs3894886; rs3966262; rs2079568; rs2330816; rs2330809; rs2330798; rs2877223; rs4049902; rs8139073; rs4049865; rs4049850; rs4049857; rs2877228; rs28663139; rs4049837; rs4049873; rs4049867; rs4049860; rs28545702; rs34659550; rs3865654; rs4049863; rs28377326; rs3865651; rs4535160; rs4049839; rs11913428; rs2096530; rs28366457; rs4049828; rs3865649; rs9608303; rs4049861; rs6004202; rs2330853; rs6004200; rs4049833; rs10602389; rs9624512; rs4049875; rs2330849; rs3865659; rs3966245; rs2330852; rs12167273; rs4049847; rs2096529; rs4049868; rs7287997; rs4049880; rs4049835; rs3865653; rs11703306; rs4049878; rs2330846; rs3865657; rs35411004; rs2330850; rs5760509; rs12168759; rs9620404; rs4049870; rs9612673; rs5760510; rs4049836; rs28441370; rs12170528; rs4049849; rs4049827; rs4049851; rs3865655; rs4049872; rs3865650; rs6004205; rs5751911; rs4049858; rs4049879; rs2877229; rs2330845; rs6004201; rs12159496; rs4426615; rs4049838; rs2877230; rs12168762; rs28418841; rs4049877; rs3876106; rs28477676; rs5760503; rs3938847; rs9620400; rs2330847; rs4049842; rs28402861; rs28718168; rs3865658; rs4049856; rs2877227; rs12166510; rs4049832; rs7284160; rs2105500; rs11416248; rs493075; rs2877231; rs3966265; rs2330851; rs3966264; rs6004198; rs3897519; rs4049864; rs4049854; rs4049830; rs3865656; rs2845424; rs9612672; rs5751465; rs4049871; rs11912608; rs9620401; rs2330840; rs4049859; rs28451181; rs4049834; rs4049862; rs9612679; rs3034881; rs4049874; rs3865652; rs35525727; rs3035043; rs12158857; rs2330854; rs35882418; rs5760483; rs11318518; rs11913638; rs12158094; rs16978739; rs2070477; rs2154611; rs4820599; rs5760485; rs5760488; rs7287904; rs737128; rs743369; rs743370; rs762286; rs874852; rs928785; rs9608299; rs9830

# Metabolic_Enzyme_7_General_References:
2904146; 2907498; 2563599; 2568315; 1968061; 1378736; 7689219; 10591208; 2896486; 10392451; 19463; 2900635; 8095045; 7759490; 7673200; 8827453

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
6093

# Metabolic_Enzyme_8_Name:
Glutathione S-transferase kappa 1

# Metabolic_Enzyme_8_Synonyms:
GST 13-13; Glutathione S-transferase subunit 13; GST class-kappa; GSTK1-1; hGSTK1

# Metabolic_Enzyme_8_Gene_Name:
GSTK1

# Metabolic_Enzyme_8_Protein_Sequence:
>Glutathione Stransferase kappa 1
MGPLPRTVELFYDVLSPYSWLGFEILCRYQNIWNINLQLRPSLITGIMKDSGNKPPGLLP
RKGLYMANDLKLLRHHLQIPIHFPKDFLSVMLEKGSLSAMRFLTAVNLEHPEMLEKASRE
LWMRVWSRNEDITEPQSILAAAEKAGMSAEQAQGLLEKIATPKVKNQLKETTEAACRYGA
FGLPITVAHVDGQTHMLFGSDRMELLAHLLGEKWMGPIPPAVNARL

# Metabolic_Enzyme_8_Number_of_Residues:
226

# Metabolic_Enzyme_8_Molecular_Weight:
25497

# Metabolic_Enzyme_8_Theoretical_pI:
8.69

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  disulfide oxidoreductase activity
Function:  protein disulfide oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  periplasmic space
Component:  periplasmic space (sensu Gram-negative Bacteria)

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB)

# Metabolic_Enzyme_8_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_8_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF01323:DSBA

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_8_GenBank_ID_Protein:
41351794

# Metabolic_Enzyme_8_SwissProt_ID:
GSTK1_HUMAN (Q9Y2Q3)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
GSTK1

# Metabolic_Enzyme_8_Geneatlas_id:
GSTK1

# Metabolic_Enzyme_8_hgnc_id:
HGNC:16906

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_8_Gene_Sequence:
>681 bp
ATGGGGCCCCTGCCGCGCACCGTGGAGCTCTTCTATGACGTGCTGTCCCCCTACTCCTGG
CTGGGCTTCGAGATCCTGTGCCGGTATCAGAATATCTGGAACATCAACCTGCAGTTGCGG
CCCAGCCTCATAACAGGGATCATGAAAGACAGTGGAAACAAGCCTCCAGGTCTGCTTCCC
CGCAAAGGACTATACATGGCAAATGACTTAAAGCTCCTGAGACACCATCTCCAGATTCCC
ATCCACTTCCCCAAGGATTTCTTGTCTGTGATGCTTGAAAAAGGAAGTTTGTCTGCCATG
CGTTTCCTCACCGCCGTGAACTTGGAGCATCCAGAGATGCTGGAGAAAGCGTCCCGGGAG
CTGTGGATGCGCGTCTGGTCAAGGAATGAAGACATCACCGAGCCGCAGAGCATCCTGGCG
GCTGCAGAGAAGGCTGGTATGTCTGCAGAACAAGCCCAGGGACTTCTGGAAAAGATCGCA
ACGCCAAAGGTGAAGAACCAGCTCAAGGAGACCACTGAGGCAGCCTGCAGATACGGAGCC
TTTGGGCTGCCCATCACCGTGGCCCATGTGGATGGCCAAACCCACATGTTATTTGGCTCT
GACCGGATGGAGCTGCTGGCGCACCTGCTGGGAGAGAAGTGGATGGGCCCTATACCTCCA
GCCGTGAATGCCAGACTTTAA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
AY520571

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_8_Locus:
-

# Metabolic_Enzyme_8_SNPs:
rs7803893; rs17164171; rs1917760; rs41275042; rs11552016; rs7786667; rs1043436; rs2367808; rs11296238; rs13311357; rs35527374; rs41276045; rs2367807; rs10275885; rs28969567; rs35125014; rs7458960; rs10952543; rs4557614; rs6464540; rs7806716

# Metabolic_Enzyme_8_General_References:
11042152; 11230166

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
6094

# Metabolic_Enzyme_9_Name:
Microsomal glutathione S-transferase 3

# Metabolic_Enzyme_9_Synonyms:
Microsomal GST- 3; Microsomal GST-III

# Metabolic_Enzyme_9_Gene_Name:
MGST3

# Metabolic_Enzyme_9_Protein_Sequence:
>Microsomal glutathione Stransferase 3
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRA
HQNTLEVYPPFLFFLAVGGVYHPRIASGLGLAWIVGRVLYAYGYYTGEPSKRSRGALGSI
ALLGLVGTTVCSAFQHLGWVKSGLGSGPKCCH

# Metabolic_Enzyme_9_Number_of_Residues:
152

# Metabolic_Enzyme_9_Molecular_Weight:
16516

# Metabolic_Enzyme_9_Theoretical_pI:
9.68

# Metabolic_Enzyme_9_GO_Classification:
Not Available

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
Also functions as a glutathione peroxidase

# Metabolic_Enzyme_9_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_9_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF01124:MAPEG

# Metabolic_Enzyme_9_Signals:
1-25

# Metabolic_Enzyme_9_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_9_GenBank_ID_Protein:
2583081

# Metabolic_Enzyme_9_SwissProt_ID:
MGST3_HUMAN (O14880)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
MGST3

# Metabolic_Enzyme_9_Geneatlas_id:
MGST3

# Metabolic_Enzyme_9_hgnc_id:
HGNC:7064

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Microsome; microsomal membrane; multi-pass membrane protein (Potential)

# Metabolic_Enzyme_9_Gene_Sequence:
>459 bp
ATGGCTGTCCTCTCTAAGGAATATGGTTTTGTGCTTCTAACTGGTGCTGCCAGCTTTATA
ATGGTGGCCCACCTAGCCATCAATGTTTCCAAGGCCCGCAAGAAGTACAAAGTGGAGTAT
CCTATCATGTACAGCACGGACCCTGAAAATGGGCACATCTTCAACTGCATTCAGCGAGCC
CACCAGAACACGTTGGAAGTGTATCCTCCCTTCTTATTTTTTCTAGCTGTTGGAGGTGTT
TACCACCCGCGTATAGCTTCTGGCCTGGGCTTGGCCTGGATTGTTGGACGAGTTCTTTAT
GCTTATGGCTATTACACGGGAGAACCCAGCAAGCGTAGTCGAGGAGCCCTGGGGTCCATC
GCCCTCCTGGGCTTGGTGGGCACAACTGTGTGCTCTGCTTTCCAGCATCTTGGTTGGGTT
AAAAGTGGCTTGGGCAGTGGACCCAAATGCTGCCATTAA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AF026977

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_9_Locus:
1q23

# Metabolic_Enzyme_9_SNPs:
rs959617; rs957644; rs1878076; rs4147594; rs9333387; rs7521640; rs6686643; rs6664209; rs1538114; rs9333413; rs4147599; rs7554034; rs4147596; rs2018265; rs4147600; rs2348726; rs4147595; rs9333380; rs4147597; rs9333395; rs4290038; rs9333379; rs9333386; rs9333455; rs16848502; rs9333372; rs9333376; rs10800120; rs2065942; rs8133; rs10918226; rs9333378; rs9333464; rs9333454; rs6692264; rs9333434; rs9333461; rs9333460; rs4147598; rs1981167; rs9333370; rs9333402; rs9333441; rs9287064; rs9333417; rs9333433; rs9333404; rs9333396; rs9333431; rs9333369; rs9333405; rs9333458; rs9333430; rs9333428; rs9333486; rs6681; rs9333398; rs9333374; rs9333377; rs9333420; rs9333465; rs12568167; rs9333453; rs9333384; rs9333375; rs9333452; rs9333448; rs9333449; rs9333436; rs9333442; rs9333392; rs9333389; rs9333432; rs9333373; rs9333394; rs9333456; rs9333446; rs6674205; rs9333437; rs9333424; rs7523515; rs9333451; rs9333410; rs9333445; rs9333419; rs9333429; rs9333423; rs9333435; rs9333444; rs9333416; rs9333418; rs9333438; rs9333393; rs9333397; rs9333462; rs9333425; rs9333383; rs9333382; rs9333422; rs9333427; rs10737516; rs9333447; rs9333439; rs9333407; rs9333463; rs9333426; rs9333421; rs9333401; rs9333400; rs9333414; rs2297765; rs2271657; rs7533986; rs7549511; rs9333483; rs2297762; rs4147605; rs9333468; rs3795540; rs4147606; rs7527279; rs4147603; rs10800122; rs11799886; rs11800476; rs4147610; rs2297763; rs4147601; rs9333470; rs9333473; rs4147602; rs4147604; rs10918229; rs9333475; rs9333471; rs9333476; rs9333467; rs9287065; rs4314865; rs9333474; rs9333479; rs9333480; rs9333485; rs9333391; rs9333469; rs9333484; rs4147608; rs7534359; rs10918228; rs4147609; rs9333472; rs4147607; rs16848876; rs7549692; rs4626863; rs7516587; rs7549530; rs10918223; rs10737515; rs4147592; rs9333490; rs12040685; rs10800118; rs6426925; rs6426926; rs4147611; rs6694924; rs9333489; rs4147593; rs4147591; rs9333367; rs6657788; rs9333365; rs9333366; rs11538247; rs1802088; rs1802087; rs17850026; rs1802085; rs11538250; rs10102; rs9333415; rs35020416; rs35795164; rs9333443; rs34624979; rs12022491; rs9333371; rs34202236; rs7415948; rs9333390; rs9333412; rs6672982; rs36081272; rs9333409; rs35843675; rs955596; rs4504867; rs9333408; rs34953802; rs13373835; rs35563509; rs4294391; rs34899242; rs34612543; rs9333457; rs9333406; rs34399622; rs1415499; rs11591043; rs12091917; rs34669783; rs9333403; rs34340940; rs35503830; rs959616; rs7413532; rs7554041; rs9333450; rs12043601; rs10603252; rs9333381; rs9333459; rs9333388; rs1137826; rs9333399; rs11576611; rs35326255; rs9333440; rs9333411; rs5778468; rs1802086; rs9333385; rs35538058; rs11576383; rs7415511; rs2297764; rs34939445; rs9333478; rs10642555; rs11589795; rs33995347; rs12568385; rs34608497; rs9333477; rs28513346; rs35870990; rs12748251; rs9333487; rs9333491; rs36217194; rs34861431; rs9333488; rs9333364; rs9333368; rs10587815; rs10494446; rs10494447; rs10800123; rs10800125; rs10800126; rs10918231; rs11484792; rs11506; rs11799903; rs11808590; rs11809495; rs11809976; rs12060366; rs12070650; rs12670; rs1415502; rs16848958; rs16849041; rs1832296; rs1878074; rs1878075; rs1913836; rs1913837; rs1913838; rs2348733; rs3738191; rs3820362; rs4504864; rs6672933; rs6679779; rs6689903; rs6690679; rs6693448; rs6701006; rs7511691; rs7518869; rs7551594; rs9164

# Metabolic_Enzyme_9_General_References:
9278457

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
6095

# Metabolic_Enzyme_10_Name:
Glutathione S-transferase Mu 3

# Metabolic_Enzyme_10_Synonyms:
GSTM3-3; GST class-mu 3; hGSTM3-3

# Metabolic_Enzyme_10_Gene_Name:
GSTM3

# Metabolic_Enzyme_10_Protein_Sequence:
>Glutathione Stransferase Mu 3
MSCESSMVLGYWDIRGLAHAIRLLLEFTDTSYEEKRYTCGEAPDYDRSQWLDVKFKLDLD
FPNLPYLLDGKNKITQSNAILRYIARKHNMCGETEEEKIRVDIIENQVMDFRTQLIRLCY
SSDHEKLKPQYLEELPGQLKQFSMFLGKFSWFAGEKLTFVDFLTYDILDQNRIFDPKCLD
EFPNLKAFMCRFEALEKIAAYLQSDQFCKMPINNKMAQWGNKPVC

# Metabolic_Enzyme_10_Number_of_Residues:
225

# Metabolic_Enzyme_10_Molecular_Weight:
26560

# Metabolic_Enzyme_10_Theoretical_pI:
5.19

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  glutathione transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Not Available

# Metabolic_Enzyme_10_Specific_Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers

# Metabolic_Enzyme_10_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_10_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_10_GenBank_ID_Protein:
306820

# Metabolic_Enzyme_10_SwissProt_ID:
GSTM3_HUMAN (P21266)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
GSTM3

# Metabolic_Enzyme_10_Geneatlas_id:
GSTM3

# Metabolic_Enzyme_10_hgnc_id:
HGNC:4635

# Metabolic_Enzyme_10_PDB_ID:
3GTU

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_10_Gene_Sequence:
>678 bp
ATGTCGTGCGAGTCGTCTATGGTTCTCGGGTACTGGGATATTCGTGGGCTGGCGCACGCC
ATCCGCCTGCTCCTGGAGTTCACGGATACCTCTTATGAGGAGAAACGGTACACGTGCGGG
GAAGCTCCTGACTATGATCGAAGCCAATGGCTGGATGTGAAATTCAAGCTAGACCTGGAC
TTTCCTAATCTGCCCTACCTCCTGGATGGGAAGAACAAGATCACCCAGAGCAATGCCATC
TTGCGCTACATCGCTCGCAAGCACAACATGTGTGGTGAGACTGAAGAAGAAAAGATTCGA
GTGGACATCATAGAGAACCAAGTAATGGATTTCCGCACACAACTGATAAGGCTCTGTTAC
AGCTCTGACCACGAAAAACTGAAGCCTCAGTACTTGGAAGAGCTACCTGGACAACTGAAA
CAATTCTCCATGTTTCTGTGGAAATTCTCATGGTTTGCCGGGGAAAAGCTCACCTTTGTG
GATTTTCTCACCTATGATATCTTGGATCAGAACCGTATATTTGACCCCAAGTGCCTGGAT
GAGTTCCCAAACCTGAAGGCTTTCATGTGCCGTTTTGAGGCTTTGGAGAAAATCGCTGCC
TACTTACAGTCTGATCAGTTCTGCAAGATGCCCATCAACAACAAGATGGCCCAGTGGGGC
AACAAGCCTGTATGCTGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
J05459

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_10_Locus:
1p13.3

# Metabolic_Enzyme_10_SNPs:
rs7483; rs1803687; rs1537236; rs1332018; rs2234696; rs3814309; rs1803688; rs1109138; rs10857799; rs1537235; rs1055259; rs10857798; rs1571858; rs1537234; rs1799735; rs10735234; rs1927328; rs4970737; rs1360513; rs4970777; rs4646412; rs11555177; rs1803685; rs12058634; rs12139578; rs12040968; rs34865003; rs28377431; rs36210754; rs36210413; rs5776997; rs12087868; rs34655210; rs41283504; rs34130836; rs10579741; rs35065437; rs36120609; rs41283506; rs35513350; rs12036509; rs34005454; rs36210756; rs11101992; rs15864; rs34550071; rs4970776; rs943639

# Metabolic_Enzyme_10_General_References:
2345169; 9882431; 8373352; 8218382; 10587441

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5308

# Metabolic_Enzyme_11_Name:
Prostaglandin E synthase

# Metabolic_Enzyme_11_Synonyms:
Microsomal glutathione S- transferase 1-like 1; MGST1-L1; p53-induced apoptosis protein 12

# Metabolic_Enzyme_11_Gene_Name:
PTGES

# Metabolic_Enzyme_11_Protein_Sequence:
>Prostaglandin E synthase
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL

# Metabolic_Enzyme_11_Number_of_Residues:
152

# Metabolic_Enzyme_11_Molecular_Weight:
17103

# Metabolic_Enzyme_11_Theoretical_pI:
9.77

# Metabolic_Enzyme_11_GO_Classification:
Not Available

# Metabolic_Enzyme_11_General_Function:
Not Available

# Metabolic_Enzyme_11_Specific_Function:
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15- dihydroxy-9-oxoprosta-5,13-dienoate

# Metabolic_Enzyme_11_Pathway:
map00590  Prostaglandin and leukotriene metabolism

# Metabolic_Enzyme_11_Reaction:
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF01124:MAPEG

# Metabolic_Enzyme_11_Signals:
1-31

# Metabolic_Enzyme_11_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 5.3.99.3

# Metabolic_Enzyme_11_GenBank_ID_Protein:
2415308

# Metabolic_Enzyme_11_SwissProt_ID:
PTGES_HUMAN (O14684)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
PTGES

# Metabolic_Enzyme_11_Geneatlas_id:
PTGES

# Metabolic_Enzyme_11_hgnc_id:
HGNC:9599

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential)

# Metabolic_Enzyme_11_Gene_Sequence:
>462 bp
ATGCCTGCCCACAGCCTGGTGATGAGCAGCCCGGCCCTCCCGGCCTTCCTGCTCTGCAGC
ACGCTGCTGGTCATCAAGATGTACGTGGTGGCCATCATCACGGGCCAAGTGAGGCTGCGG
AAGAAGGCCTTTGCCAACCCCGAGGATGCCCTGAGACACGGAGGAGGCCCCCAGTATTGC
AGGAGCGACCCCGACGTGGAACGCTGCCTCAGGGCCCACCGGAACGACATGGAGACCATC
TACCCCTTCCTTTTCCTGGGCTTCGTCTACTCCTTTCTGGGTCCTAACCCTTTTGTCGCC
TGGATGCACTTCCTGGTCTTCCTCGTGGGCCGTGTGGCACACACCGTGGCCTACCTGGGG
AAGCTGCGGGCACCCATCCGCTCCGTGACCTACACCCTGGCCCAGCTCCCCTGCGCCTCC
ATGGCTCTGCAGATCCTCTGGGAAGCGGCCCGCCACCTGTGA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
AF010316

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_11_Locus:
9q34.3

# Metabolic_Enzyme_11_SNPs:
rs3205181; rs11792431; rs1801978; rs3844047; rs2302821; rs3892538; rs3892537; rs920658; rs2241271; rs12553596; rs4837404; rs10819563; rs12553174; rs10988492; rs10448290; rs4837408; rs10448289; rs10739757; rs12683177; rs10988490; rs10819562; rs12551591; rs4837406; rs16931431; rs10760633; rs11999683; rs11790782; rs10988487; rs4837403; rs12004095; rs11788591; rs4837405; rs10760634; rs11791984; rs4836669; rs4837407; rs10760636; rs16931434; rs11789635; rs10819564; rs1808904; rs10988493; rs16931445; rs7028642; rs1965820; rs11793850; rs10988491; rs7467413; rs12553592; rs2241270; rs7021162; rs10121317; rs10760635; rs10988488; rs7872802; rs7026096; rs7859349; rs7873087; rs6478914; rs7026441; rs10119273; rs3861883; rs3884098; rs33945195; rs11547594; rs35042232; rs36206118; rs41312196; rs1134679; rs35653229; rs1972919; rs2417148; rs12554766; rs34789851; rs35083107; rs35486768; rs10988489; rs35960834; rs34392118; rs34272132; rs7858280; rs7858196; rs12376507; rs11322118; rs11792427; rs1808903; rs35914995; rs4147585; rs4147584; rs34737030; rs34316279; rs34337580; rs10988494; rs10448288; rs34989168; rs7873707; rs4147583; rs34563958; rs36035927; rs34189921; rs10608530; rs10988486; rs34042102; rs7042752; rs3983774; rs36022765; rs10118377; rs10988484; rs10988496; rs10988497; rs11788220; rs11788228; rs11790822; rs11999368; rs12001450; rs12001465; rs12001470; rs12005547; rs16931419; rs17417877; rs3844048; rs4636306; rs6478915; rs7025976; rs7027762; rs7855291; rs930487; rs9722408

# Metabolic_Enzyme_11_General_References:
9305847; 10377395; 10760517

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
6096

# Metabolic_Enzyme_12_Name:
Glutathione S-transferase A1

# Metabolic_Enzyme_12_Synonyms:
GTH1; HA subunit 1; GST- epsilon; GSTA1-1; GST class-alpha member 1

# Metabolic_Enzyme_12_Gene_Name:
GSTA1

# Metabolic_Enzyme_12_Protein_Sequence:
>Glutathione Stransferase A1
MAEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAK
LALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIFRF

# Metabolic_Enzyme_12_Number_of_Residues:
222

# Metabolic_Enzyme_12_Molecular_Weight:
25631

# Metabolic_Enzyme_12_Theoretical_pI:
9.34

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  glutathione transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Not Available

# Metabolic_Enzyme_12_Specific_Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

# Metabolic_Enzyme_12_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_12_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Metabolic_Enzyme_12_Signals:
None

# Metabolic_Enzyme_12_Transmembrane_Regions:
None

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_12_GenBank_ID_Protein:
306809

# Metabolic_Enzyme_12_SwissProt_ID:
GSTA1_HUMAN (P08263)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
GSTA1

# Metabolic_Enzyme_12_Geneatlas_id:
GSTA1

# Metabolic_Enzyme_12_hgnc_id:
HGNC:4626

# Metabolic_Enzyme_12_PDB_ID:
1K3Y

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_12_Gene_Sequence:
>669 bp
ATGGCAGAGAAGCCCAAGCTCCACTACTTCAATGCACGGGGCAGAATGGAGTCCACCCGG
TGGCTCCTGGCTGCAGCTGGAGTAGAGTTTGAAGAGAAATTTATAAAATCTGCAGAAGAT
TTGGACAAGTTAAGAAATGATGGATATTTGATGTTCCAGCAAGTGCCAATGGTTGAGATT
GATGGGATGAAGCTGGTGCAGACCAGAGCCATTCTCAACTACATTGCCAGCAAATACAAC
CTCTATGGGAAAGACATAAAGGAGAGAGCCCTGATTGATATGTATATAGAAGGTATAGCA
GATTTGGGTGAAATGATCCTCCTTCTGCCCGTATGTCCACCTGAGGAAAAAGATGCCAAG
CTTGCCTTGATCAAGGAGAAAATAAAAAATCGCTACTTCCCTGCCTTTGAAAAAGTCTTA
AAGAGCCATGGACAAGACTACCTTGTTGGCAACAAGCTGAGCCGGGCTGACATTCATCTG
GTGGAACTTCTCTACTACGTCGAGGAGCTTGACTCCAGTCTTATCTCCAGCTTCCCTCTG
CTGAAGGCCCTGAAAACCAGAATCAGCAACCTGCCCACAGTGAAGAAGTTTCTACAGCCT
GGCAGCCCAAGGAAGCCTCCCATGGATGAGAAATCTTTAGAAGAAGCAAGGAAGATTTTC
AGGTTTTAA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
M15872

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_12_Locus:
6p12.1

# Metabolic_Enzyme_12_SNPs:
Not Available

# Metabolic_Enzyme_12_General_References:
3800996; 3036131; 3678589; 3031680; 1731620; 3138230; 8431482; 2604726; 2018473; 8331657; 8591048

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
6097

# Metabolic_Enzyme_13_Name:
Maleylacetoacetate isomerase

# Metabolic_Enzyme_13_Synonyms:
MAAI; Glutathione S- transferase zeta 1; GSTZ1-1

# Metabolic_Enzyme_13_Gene_Name:
GSTZ1

# Metabolic_Enzyme_13_Protein_Sequence:
>Maleylacetoacetate isomerase
MQAGKPILYSYFRSSCSWRVRIALALKGIDYKTVPINLIKDRGQQFSKDFQALNPMKQVP
TLKIDGITIHQSLAIIEYLEETRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLK
QVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDL
TPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA

# Metabolic_Enzyme_13_Number_of_Residues:
216

# Metabolic_Enzyme_13_Molecular_Weight:
24182

# Metabolic_Enzyme_13_Theoretical_pI:
8.71

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_13_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_13_Specific_Function:
Bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4- nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T- butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid

# Metabolic_Enzyme_13_Pathway:
map00350  Tyrosine metabolism;
 map00643  Styrene degradation

# Metabolic_Enzyme_13_Reaction:
4-maleylacetoacetate = 4-fumarylacetoacetate

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
None

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 5.2.1.2;EC 2.5.1.18

# Metabolic_Enzyme_13_GenBank_ID_Protein:
2832731

# Metabolic_Enzyme_13_SwissProt_ID:
MAAI_HUMAN (O43708)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
GSTZ1

# Metabolic_Enzyme_13_Geneatlas_id:
GSTZ1

# Metabolic_Enzyme_13_hgnc_id:
HGNC:4643

# Metabolic_Enzyme_13_PDB_ID:
1FW1

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_13_Gene_Sequence:
>651 bp
ATGCAGGCGGGGAAGCCCATCCTCTATTCCTATTTCCGAAGCTCCTGCTCATGGAGAGTT
CGAATTGCTCTGGCCTTGAAAGGCATCGACTACAAGACGGTGCCCATCAATCTCATAAAG
GATGGGGGCCAACAGTTTTCTAAGGACTTCCAGGCACTGAATCCTATGAAGCAGGTGCCA
ACCCTGAAGATTGATGGAATCACCATTCACCAGTCACTGGCCATCATTGAGTATCTAGAG
GAGACGCGTCCCACTCCGCGACTTCTGCCTCAGGACCCAAAGAAGAGGGCCAGCGTGCGT
ATGATTTCTGACCTCATCGCTGGTGGCATCCAGCCCCTGCAGAACCTGTCTGTCCTGAAG
CAAGTGGGAGAGGAGATGCAGCTGACCTGGGCCCAGAACGCCATCACTTGTGGCTTTAAC
GCCCTGGAGCAGATCCTACAGAGCACAGCGGGCATATACTGTGTAGGAGACGAGGTGACC
ATGGCTGATCTGTGCTTGGTGCCTCAGGTGGCAAATGCTGAAAGATTCAAGGTGGATCTC
ACCCCCTACCCTACCATCAGCTCCATCAACAAGAGGCTGCTGGTCTTGGAGGCCTTCCAG
GTGTCTCACCCCTGCCGGCAGCCAGATACACCCACTGAGCTGAGGGCCTAG

# Metabolic_Enzyme_13_GenBank_ID_Gene:
AJ001838

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_13_Locus:
14q24.3

# Metabolic_Enzyme_13_SNPs:
rs1046428; rs2234955; rs7972; rs3177427; rs1861887; rs8004561; rs2270422; rs7142535; rs2234738; rs5809822; rs8004558; rs8016187; rs2234737; rs3742739; rs2287395; rs8177546; rs8177551; rs1468951; rs8177555; rs8177552; rs8177550; rs8177559; rs8177547; rs8177548; rs8177557; rs4147578; rs731346; rs2287396; rs888411; rs8177570; rs888410; rs8177573; rs5809824; rs8177571; rs2270423; rs2287397; rs8177562; rs8177569; rs8177565; rs8177567; rs1017186; rs1800199; rs17105715; rs8177549; rs8177575; rs35412338; rs8177556; rs34853065; rs2885855; rs5809823; rs3037047; rs4147579; rs8177554; rs11287763; rs35612979; rs8177560; rs8177558; rs10716979; rs8177553; rs8177561; rs10584256; rs8177566; rs8177568; rs8177563; rs8177572; rs8177564; rs8177574; rs41285488; rs34553858; rs5809825; rs11319759; rs12898118; rs35278065; rs34442366; rs10132619; rs11624726; rs11850771; rs12441; rs2111699; rs2160837; rs2160838; rs2234736; rs2234954; rs2270421; rs2363640; rs2363641; rs2363643; rs3759731; rs3759732; rs3759733; rs3759734; rs4899651; rs6636; rs6637; rs7153544; rs8177535; rs8177537; rs8177538; rs8177539; rs8177544; rs9671248

# Metabolic_Enzyme_13_General_References:
9417084; 9396740; 9925947; 10373324; 12508121; 9531472; 10739172; 11327815

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
6098

# Metabolic_Enzyme_14_Name:
Glutathione S-transferase theta-2

# Metabolic_Enzyme_14_Synonyms:
GST class-theta-2

# Metabolic_Enzyme_14_Gene_Name:
GSTT2

# Metabolic_Enzyme_14_Protein_Sequence:
>Glutathione Stransferase theta2
MGLELFLDLVSQPSRAVYIFAKKNGIPLELRTVDLVKGQHKSKEFLQINSLGKLPTLKDG
DFILTESSAILIYLSCKYQTPDHWYPSDLQARARVHEYLGWHADCIRGTFGIPLWVQVLG
PLIGVQVPEEKVERNRTAMDQALQWLEDKFLGDRPFLAGQQVTLADLMALEELMQPVALG
YELFEGRPRLAAWRGRVEAFLGAELCQEAHSIILSILEQAAKKTLPTPSPEAYQAMLLRI
ARIP

# Metabolic_Enzyme_14_Number_of_Residues:
244

# Metabolic_Enzyme_14_Molecular_Weight:
27507

# Metabolic_Enzyme_14_Theoretical_pI:
6.36

# Metabolic_Enzyme_14_GO_Classification:
Not Available

# Metabolic_Enzyme_14_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_14_Specific_Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity

# Metabolic_Enzyme_14_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_14_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Metabolic_Enzyme_14_Signals:
1-16

# Metabolic_Enzyme_14_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_14_GenBank_ID_Protein:
601918

# Metabolic_Enzyme_14_SwissProt_ID:
GSTT2_HUMAN (P30712)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
GSTT2

# Metabolic_Enzyme_14_Geneatlas_id:
GSTT2

# Metabolic_Enzyme_14_hgnc_id:
HGNC:4642

# Metabolic_Enzyme_14_PDB_ID:
3LJR

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_14_Gene_Sequence:
>735 bp
ATGGGCCTAGAGCTGTTTCTTGACCTGGTGTCCCAGCCCAGCCGCGCCGTCTACATCTTC
GCCAAGAAGAATGGCATCCCCTTAGAGCTGCGCACCGTGGATTTGGTCAAAGGGCAGCAC
AAGAGCAAGGAGTTCTTGCAGATCAACAGCCTGGGGAAACTGCCGACGCTCAAGGATGGT
GATTTCATCTTGACCGAAAGCTCGGCCATCCTGATTTACCTGAGCTGTAAGTACCAGACG
CCGGACCACTGGTATCCATCTGACCTGCAGGCTCGTGCCCGTGTTCATGAGTACCTGGGC
TGGCATGCCGACTGCATCCGTGGCACCTTTGGTATACCCCTGTGGGTCCAGGTGTTGGGG
CCACTCATTGGGGTCCAGGTGCCCGAGGAGAAGGTGGAACGCAACAGGACTGCCATGGAC
CAGGCCCTGCAATGGCTGGAGGACAAGTTCCTGGGGGACAGGCCCTTCCTCGCTGGCCAG
CAGGTGACACTGGCTGATCTCATGGCCCTGGAGGAGCTGATGCAGCCGGTGGCTCTCGGC
TACGAACTGTTTGAGGGACGGCCACGACTGGCAGCATGGCGTGGACGAGTGGAGGCTTTC
CTGGGTGCTGAGCTATGCCAGGAGGCCCACAGCATCATCTTGAGCATCCTGGAACAGGCG
GCCAAGAAAACCCTCCCAACACCCTCACCAGAGGCCTATCAGGCTATGCTGCTTCGAATC
GCCAGGATCCCCTGA

# Metabolic_Enzyme_14_GenBank_ID_Gene:
L38503

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_14_Locus:
22q11.2|22q11.23

# Metabolic_Enzyme_14_SNPs:
Not Available

# Metabolic_Enzyme_14_General_References:
7789971; 10975610; 10591208; 1417752; 8761485; 9551553

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
6099

# Metabolic_Enzyme_15_Name:
Microsomal glutathione S-transferase 1

# Metabolic_Enzyme_15_Synonyms:
Microsomal GST- 1; Microsomal GST-I

# Metabolic_Enzyme_15_Gene_Name:
MGST1

# Metabolic_Enzyme_15_Protein_Sequence:
>Microsomal glutathione Stransferase 1
MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAK
KYLRTDDRVERVRRAHLNDLENIIPFLGIGLLYSLSGPDPSTAILHFRLFVGARIYHTIA
YLTPLPQPNRALSFFVGYGVTLSMAYRLLKSKLYL

# Metabolic_Enzyme_15_Number_of_Residues:
155

# Metabolic_Enzyme_15_Molecular_Weight:
17599

# Metabolic_Enzyme_15_Theoretical_pI:
9.71

# Metabolic_Enzyme_15_GO_Classification:
Not Available

# Metabolic_Enzyme_15_General_Function:
Not Available

# Metabolic_Enzyme_15_Specific_Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity

# Metabolic_Enzyme_15_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_15_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF01124:MAPEG

# Metabolic_Enzyme_15_Signals:
1-35

# Metabolic_Enzyme_15_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_15_GenBank_ID_Protein:
306808

# Metabolic_Enzyme_15_SwissProt_ID:
MGST1_HUMAN (P10620)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
MGST1

# Metabolic_Enzyme_15_Geneatlas_id:
MGST1

# Metabolic_Enzyme_15_hgnc_id:
HGNC:7061

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Microsome. Mitochondrion; mitochondrial outer membrane; peripheral membrane protein (By similarity)

# Metabolic_Enzyme_15_Gene_Sequence:
>468 bp
ATGGTTGACCTCACCCAGGTAATGGATGATGAAGTATTCATGGCTTTTGCATCCTATGCA
ACAATTATTCTTTCAAAAATGATGCTTATGAGTACTGCAACTGCATTCTATAGATTGACA
AGAAAGGTTTTTGCCAATCCAGAAGACTGTGTAGCATTTGGCAAAGGAGAAAATGCCAAG
AAGTATCTTCGAACAGATGACAGAGTAGAACGTGTACGCAGAGCCCACCTGAATGACCTT
GAAAATATTATTCCATTTCTTGGAATTGGCCTCCTGTATTCCTTGAGTGGTCCCGACCCC
TCTACAGCCATCCTGCACTTCAGACTATTTGTCGGAGCACGGATCTACCACACCATTGCA
TATTTGACACCCCTTCCCCAGCCAAATAGAGCTTTGAGTTTTTTTGTTGGATATGGAGTT
ACTCTTTCCATGGCTTACAGGTTGCTGAAAAGTAAATTGTACCTGTAA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
J03746

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_15_Locus:
12p12.3-p12.1

# Metabolic_Enzyme_15_SNPs:
rs1042669; rs7294985; rs11875; rs2975149; rs7962259; rs1913262; rs7980164; rs3741805; rs2239676; rs9332879; rs2975139; rs3759209; rs1913264; rs2239677; rs2975143; rs4149190; rs2975151; rs9332882; rs4149206; rs2239675; rs9332884; rs3028593; rs9332897; rs9332881; rs9332876; rs9332899; rs9332878; rs9332893; rs9332885; rs9332895; rs9332874; rs9332883; rs9332890; rs2947103; rs9332892; rs9332888; rs9332901; rs9332877; rs9332894; rs1803678; rs2947104; rs4149188; rs1913263; rs2975138; rs2287152; rs1828682; rs4149203; rs3844373; rs2075240; rs7312090; rs4149204; rs3852576; rs3759207; rs2287150; rs4149205; rs9332938; rs4149200; rs4149202; rs3815566; rs7966563; rs2075239; rs4149197; rs3815565; rs9332921; rs4149199; rs3852575; rs2075238; rs4149192; rs9332935; rs4149198; rs9332924; rs4149214; rs3815564; rs9332908; rs9332923; rs2270357; rs2075237; rs9332919; rs4149218; rs9332904; rs9332934; rs9332917; rs9332943; rs2270356; rs9332939; rs9332940; rs9332903; rs9332929; rs9332941; rs9332926; rs4149195; rs4149215; rs9332920; rs9332915; rs9332936; rs9332922; rs4149186; rs7314840; rs7970208; rs4149187; rs4149207; rs6488841; rs4149208; rs12227463; rs10846332; rs9332873; rs11555873; rs9332944; rs35098979; rs2975150; rs2947108; rs9332889; rs2947105; rs2975140; rs9332891; rs9332887; rs7135902; rs11056901; rs2947109; rs2975137; rs10540313; rs11056900; rs2975145; rs2947110; rs34744585; rs9332900; rs9332946; rs35236482; rs3834479; rs9332880; rs2975141; rs9332898; rs9332875; rs2947102; rs2947106; rs2975144; rs1803679; rs11056902; rs2947107; rs9332886; rs2975146; rs9332945; rs11387725; rs35453427; rs10466861; rs2975136; rs7307751; rs2975142; rs9332896; rs2975153; rs2947101; rs9332905; rs9332912; rs9332902; rs11056903; rs9332913; rs34139482; rs9332909; rs7976472; rs9332931; rs9332910; rs9332916; rs1045365; rs9332907; rs10680890; rs4149211; rs5796668; rs35511355; rs35357582; rs2975155; rs35081887; rs11313839; rs11056904; rs2287151; rs9332914; rs9332906; rs34833634; rs35213670; rs9332932; rs9332933; rs9332937; rs2947100; rs9332911; rs9332925; rs2975154; rs4149196; rs10846334; rs9332930; rs9332927; rs10679908; rs35073888; rs12426125; rs35339992; rs11056899; rs34442318; rs1024834; rs1024838; rs1024839; rs10732572; rs10744119; rs10846336; rs10846338; rs11056889; rs11056890; rs11056892; rs11056898; rs12231060; rs12313805; rs2160512; rs4384422; rs4764267; rs6488840; rs7133802; rs7135371; rs713593; rs7303782; rs7313177; rs9332949; rs9332950; rs9332952; rs9332954; rs9332956; rs9332957; rs9332959

# Metabolic_Enzyme_15_General_References:
3372534; 8812420

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
6100

# Metabolic_Enzyme_16_Name:
Glutathione S-transferase Mu 4

# Metabolic_Enzyme_16_Synonyms:
GSTM4-4; GST class-mu 4; GTS-Mu2

# Metabolic_Enzyme_16_Gene_Name:
GSTM4

# Metabolic_Enzyme_16_Protein_Sequence:
>Glutathione Stransferase Mu 4
MSMTLGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQAMDVSNQLARVCYSPDF
EKLKPEYLEELPTMMQHFSQFLGKRPWFVGDKITFVDFLAYDVLDLHRIFEPNCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPKPLYTRVAVWGNK

# Metabolic_Enzyme_16_Number_of_Residues:
218

# Metabolic_Enzyme_16_Molecular_Weight:
25562

# Metabolic_Enzyme_16_Theoretical_pI:
5.69

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  glutathione transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Not Available

# Metabolic_Enzyme_16_Specific_Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Active on 1- chloro-2,4-dinitrobenzene

# Metabolic_Enzyme_16_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_16_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Metabolic_Enzyme_16_Signals:
1-16

# Metabolic_Enzyme_16_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_16_GenBank_ID_Protein:
306819

# Metabolic_Enzyme_16_SwissProt_ID:
GSTM4_HUMAN (Q03013)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
GSTM4

# Metabolic_Enzyme_16_Geneatlas_id:
GSTM4

# Metabolic_Enzyme_16_hgnc_id:
HGNC:4636

# Metabolic_Enzyme_16_PDB_ID:
4GTU

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_16_Gene_Sequence:
>657 bp
ATGTCCATGACACTGGGGTACTGGGACATCCGCGGGCTGGCCCACGCCATCCGCCTGCTC
CTGGAATACACAGACTCAAGCTACGAGGAAAAGAAGTATACGATGGGGGACGCTCCTGAC
TATGACAGAAGCCAGTGGCTGAATGAAAAATTCAAGCTGGGCCTAGACTTTCCCAATCTG
CCCTACTTGATTGATGGGGCTCACAAGATCACCCAGAGCAACGCCATCCTGTGCTACATT
GCCCGCAAGCACAACCTGTGTGGGGAGACAGAAGAGGAGAAGATTCGTGTGGACATTTTG
GAGAACCAGGCTATGGACGTCTCCAATCAGCTGGCCAGAGTCTGCTACAGCCCTGACTTT
GAGAAACTGAAGCCAGAATACTTGGAGGAACTTCCTACAATGATGCAGCACTTCTCACAG
TTCCTGGGGAAGAGGCCATGGTTTGTTGGAGACAAGATCACCTTTGTAGATTTCCTCGCC
TATGATGTCCTTGACCTCCACCGTATATTTGAGCCCAACTGCTTGGACGCCTTTCCAAAT
CTGAAGGACTTCATCTCCCGCTTTGAGGGCTTGGAGAAGATCTCTGCCTACATGAAGTCC
AGCCGCTTCCTCCCAAAACCTCTGTACACAAGGGTGGCTGTCTGGGGCAACAAGTAA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
M96234

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_16_Locus:
1p13.3

# Metabolic_Enzyme_16_SNPs:
rs3211190; rs17838158; rs506008; rs3211205; rs17081030; rs1010167; rs1063578; rs3211208; rs3211209; rs12031717; rs3211189; rs1063584; rs535537; rs627365; rs560018; rs670439; rs650985; rs510651; rs12405275; rs11101981; rs566394; rs524663; rs12085659; rs17024655; rs12090060; rs638007; rs542370; rs641592; rs9730013; rs3754450; rs9725364; rs6686777; rs3211194; rs3211198; rs3211193; rs3191485; rs3211203; rs3211196; rs3211197; rs3211195; rs17838156; rs3211199; rs17024663; rs3211200; rs3211204; rs3211201; rs41283498; rs1063583; rs1140629; rs1063581; rs3204619; rs1063585; rs1051137; rs11543238; rs1063580; rs1063579; rs3204620; rs3204618; rs3204614; rs1051134; rs34179167; rs4970769; rs562996; rs7554692; rs10687592; rs12566156; rs2011158; rs563003; rs11586095; rs597370; rs33962756; rs34617741; rs41280334; rs7367768; rs859222; rs36211084; rs35643538; rs5776991; rs36210761; rs35373403; rs5776992; rs36210763; rs3754448; rs36210760; rs4025939; rs1616247; rs6701058; rs34619760; rs10614579; rs36211085; rs10494109; rs1056799; rs1056800; rs11805131; rs12131828; rs3211192; rs4518929; rs521999; rs525362; rs542338; rs569998; rs592586; rs592792; rs625456; rs638820; rs661417; rs668413; rs668532; rs673151; rs681991

# Metabolic_Enzyme_16_General_References:
8349586; 8471052; 8373352; 2006920; 8203914; 10587441

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
6101

# Metabolic_Enzyme_17_Name:
Glutathione S-transferase Mu 5

# Metabolic_Enzyme_17_Synonyms:
GSTM5-5; GST class-mu 5

# Metabolic_Enzyme_17_Gene_Name:
GSTM5

# Metabolic_Enzyme_17_Protein_Sequence:
>Glutathione Stransferase Mu 5
MPMTLGYWDIRGLAHAIRLLLEYTDSSYVEKKYTLGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGAHKITQSNAILRYIARKHNLCGETEEEKIRVDILENQVMDNHMELVRLCYDPDF
EKLKPKYLEELPEKLKLYSEFLGKRPWFAGDKITFVDFLAYDVLDMKRIFEPKCLDAFLN
LKDFISRFEGLKKISAYMKSSQFLRGLLFGKSATWNSK

# Metabolic_Enzyme_17_Number_of_Residues:
218

# Metabolic_Enzyme_17_Molecular_Weight:
25675

# Metabolic_Enzyme_17_Theoretical_pI:
7.49

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  glutathione transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Not Available

# Metabolic_Enzyme_17_Specific_Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

# Metabolic_Enzyme_17_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_17_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Metabolic_Enzyme_17_Signals:
1-16

# Metabolic_Enzyme_17_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_17_GenBank_ID_Protein:
468260

# Metabolic_Enzyme_17_SwissProt_ID:
GSTM5_HUMAN (P46439)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
GSTM5

# Metabolic_Enzyme_17_Geneatlas_id:
GSTM5

# Metabolic_Enzyme_17_hgnc_id:
HGNC:4637

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_17_Gene_Sequence:
>657 bp
ATGCCCATGACTCTGGGGTACTGGGACATCCGTGGGCTGGCCCACGCCATCCGCTTGCTC
CTGGAATACACAGACTCAAGCTATGTGGAAAAGAAGTACACGATGGGGGACGCTCCTGAC
TATGACAGAAGCCAGTGGCTGAATGAAAAATTCAAGCTGGGCCTGGACTTTCCCAATCTG
CCCTACTTGATTGATGGGGCTCACAAGATCACCCAGAGCAATGCCATCCTGCGCTACATT
GCCCGCAAGCACAACCTGTGTGGGGAGACAGAAGAGGAGAAGATTCGTGTGGACATTTTG
GAGAACCAGGTTATGGATAACCACATGGAGCTGGTCAGACTGTGCTATGACCCAGATTTT
GAGAAACTGAAGCCAAAATACTTGGAGGAACTCCCTGAAAAGCTAAAGCTCTACTCAGAG
TTTCTGGGGAAGCGGCCATGGTTTGCAGGAGACAAGATCACCTTTGTGGATTTCCTTGCC
TATGATGTCCTTGACATGAAGCGTATATTTGAGCCCAAGTGCTTGGACGCCTTCCTAAAC
TTGAAGGACTTCATCTCCCGCTTTGAGGGTTTGAAGAAGATCTCTGCCTACATGAAGTCC
AGCCAATTCCTCCGAGGTCTTTTGTTTGGAAAGTCAGCTACATGGAACAGCAAATAG

# Metabolic_Enzyme_17_GenBank_ID_Gene:
L02321

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_17_Locus:
1p13.3

# Metabolic_Enzyme_17_SNPs:
rs17596954; rs11807; rs943643; rs929166; rs3768487; rs4970773; rs3768490; rs2077074; rs12729068; rs17024661; rs1808183; rs12743015; rs428135; rs12736389; rs12730212; rs886177; rs12130907; rs7539980; rs493487; rs11101990; rs7536162; rs17014553; rs1296954; rs1633365; rs11101989; rs1758104; rs1292096; rs1758109; rs414673; rs1758105; rs3754446; rs674787; rs674761; rs17854972; rs1049741; rs41283502; rs3768488; rs36107407; rs2479390; rs492732; rs3768489; rs36209414; rs35283204; rs28461755; rs3815031; rs17024723; rs12137743; rs36208872; rs3815032; rs36210088; rs12731384; rs36209416; rs3815033; rs36209415; rs36209422; rs28743105; rs1758108; rs12756544; rs35988844; rs11101986; rs11101992; rs11579576; rs12061321; rs12061448; rs12069003; rs12074494; rs12130509; rs366349; rs7553593

# Metabolic_Enzyme_17_General_References:
8473333

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
6006

# Metabolic_Enzyme_18_Name:
Gamma-glutamyltransferase 4 precursor

# Metabolic_Enzyme_18_Synonyms:
Gamma- glutamyltranspeptidase 4; Gamma-glutamyltransferase-like 3; Gamma- glutamyltransferase-like 5[Contains: Gamma-glutamyltransferase 4 heavy chain; Gamma-glutamyltransferase 4 light chain]

# Metabolic_Enzyme_18_Gene_Name:
GGTL3

# Metabolic_Enzyme_18_Protein_Sequence:
>Gammaglutamyltransferase 4 precursor
MAAENEASQESALGAYSPVDYMSITSFPRLPEDEPAPAAPLRGRKDEDAFLGDPDTDPDS
FLKSARLQRL
PSSSSEMGSQDGSPLRETRKDPFSAAAAECSCRQDGLTVIVTACLTFAT
GVTVALVMQIYFGDPQIFQQG
AVVTDAARCTSLGIEVLSKQGSSVDAAVAAALCLGIVA
PHSSGLGGGGVMLVHDIRRNESHLIDFRESAP
GALREETLQRSWETKVGTLPGLLVGVP
GMVKGLHEAHQLYGRLPWSQVLAFAAAVAQDGFNVTHDLARAL
AEQLPPNMSERFRETF
LPSGRPPLPGSLLHRPDLAEVLDVLGTSGPAAFYAGGNLTLEMVAEAQHAGGVI
TEEDF
SNYSALVEKPVCGVYRGHLVLSPPPPHTGPALISALNILEGFNLTSLVSREQALHWVAET
LKIAL
ALASRLGDPVYDSTITESMDDMLSKVEAAYLRGHINDSQAAPAPLLPVYELDGA
PTAAQVLIMGPDDFIV
AMVSSLNQPFGSGLITPSGILLNSQMLDFSWPNRTANHSAPSL
ENSVQPGKRPLSFLLPTVVRPAEGLCG
TYLALGANGAARGLSGLTQVLLNVLTLNRNLS
DSLARGRLHPDLQSNLLQVDSEFTEEEIEFLEARGHHV
EKVDVLSWVHGSRRTNNFIIA
VKDPRSPDAAGATIL

# Metabolic_Enzyme_18_Number_of_Residues:
666

# Metabolic_Enzyme_18_Molecular_Weight:
70838

# Metabolic_Enzyme_18_Theoretical_pI:
4.73

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring amino-acyl groups
Function:  gamma-glutamyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_18_Specific_Function:
Cleaves glutathione conjugates

# Metabolic_Enzyme_18_Pathway:
map00430  Taurine and hypotaurine metabolism;
 map00450  Selenoamino acid metabolism;
 map00460  Cyanoamino acid metabolism;
 map00480  Glutathione metabolism;
 map00590  Prostaglandin and leukotriene metabolism

# Metabolic_Enzyme_18_Reaction:
(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF01019:G_glu_transpept

# Metabolic_Enzyme_18_Signals:
None

# Metabolic_Enzyme_18_Transmembrane_Regions:
107-127

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 2.3.2.2

# Metabolic_Enzyme_18_GenBank_ID_Protein:
28192538

# Metabolic_Enzyme_18_SwissProt_ID:
GGT4_HUMAN (Q9UJ14)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
GGTL3

# Metabolic_Enzyme_18_Geneatlas_id:
GGTL3

# Metabolic_Enzyme_18_hgnc_id:
HGNC:4259

# Metabolic_Enzyme_18_PDB_ID:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_18_Gene_Sequence:
>756 bp

ATGGCGGCGGAGAAGGAGGCCAGCCAGGAGAGCGCCCTGGGCGCCTACTCGCCAGTGGA
CTACATGAGCA
TCACCAGCTTCCCGCGGCTGCCCGAGGACGAGCCGGCGCCCGCGGCCC
CGCTGAGGGGCCGCAAGGACGA
GGACGCCTTTCTGGGAGACCCCGACACCGACCCGGAC
TCCTTCCTGAAGTCTGCACGGCTGCAGCGGCTG
CCATCGTCGTCGTCGGAGATGGGCAG
CCAAGACGGGTCGCCGCTACGCGAGACGCGCAAAGACCCGTTCT
CCGCCGCAGCGGCCG
AGTGCTCCTGCCGCCAGGATGGGCTCACGGTCATCGTCACGGCCTGTCTCACCTT
CGCT
ACCGGTGTCACCGTGGCGCTGGTCATGCAGATCTACTTCGGGGACCCCCAGATCTTCCAG
CAGGGT
GCCGTGGTGACCGATGCTGCCCGCTGCACTTCACTGGGCATCGAGGTGCTCAG
TAAACAGGGATCTTCTG
TGGACGCAGCGGTGGCAGCAGCCTTGTGTTTGGGTATCGTGG
CTCCACACAGTTCTGGCCTGGGCGGTGG
GGGCGTGATGCTGGTACATGACATCCGACGA
AATGAGAGCCACCTAATTGATTTCCGGGAGTCCGCACCA
GGGGCCCTCAGGGAAGAGAC
CCTGCAAAGATCCTGGGAGACCAAGGTGGGGACCCTGGTGAGAAGAGAGA
GTTCAGGGG
AGTCTCTCTTCATTGCCCTTCTGCTAACCCAAGCATTAATTTGCTAA

# Metabolic_Enzyme_18_GenBank_ID_Gene:
AY138815

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_18_Locus:
20q11.22

# Metabolic_Enzyme_18_SNPs:
rs11546155; rs3746452; rs2076668; rs6088624; rs8120670; rs17092148; rs1984588; rs6120742; rs11699070; rs6119535; rs6119534; rs6119536; rs6120748; rs7263157; rs17122844; rs6120747; rs7354108; rs11697978; rs11698977; rs761481; rs7273470; rs11696546; rs17092149; rs6087639; rs6120746; rs11698996; rs2064453; rs34687214; rs6060095; rs35006054; rs6060078; rs6060079; rs7266944; rs11546156; rs6060080; rs10666634; rs10611859; rs6060082; rs6060081; rs6060077; rs34381589; rs35511575; rs10527077; rs6058126; rs8183445; rs6058127; rs6120743; rs6060084; rs6060096; rs6060097; rs34384459; rs6088627; rs41290902; rs34124885; rs35181666; rs6060090; rs11476486; rs34277320; rs33912843; rs6060098; rs41290904; rs6058129; rs34961294; rs11907458; rs34086165; rs11907128; rs6058128; rs6060099; rs6088633; rs6087640; rs5841184; rs6058125; rs8120847; rs6058130; rs6060083; rs6060103; rs6141519; rs11472270; rs35393655; rs11387013; rs11699132; rs6088629; rs7265109; rs6088628; rs12151936; rs6120744; rs6142253; rs34178465; rs34930184; rs6058124; rs6058132; rs6088631; rs11357916; rs6088632; rs6060085; rs6060092; rs6088625; rs6060088; rs6060091; rs6060102; rs6088626; rs6119531; rs36084138; rs1013677; rs12625149; rs2295095; rs2295096; rs6060072; rs6060073; rs6060074; rs6087641; rs6088635; rs6088638; rs6119540; rs7269682

# Metabolic_Enzyme_18_General_References:
12270127; 12693554; 11780052

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
6102

# Metabolic_Enzyme_19_Name:
Microsomal glutathione S-transferase 2

# Metabolic_Enzyme_19_Synonyms:
Microsomal GST- 2; Microsomal GST-II

# Metabolic_Enzyme_19_Gene_Name:
MGST2

# Metabolic_Enzyme_19_Protein_Sequence:
>Microsomal glutathione Stransferase 2
MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFY
PIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTL
LGALGIANSFLDEYLDLNIAKKLRRQF

# Metabolic_Enzyme_19_Number_of_Residues:
147

# Metabolic_Enzyme_19_Molecular_Weight:
16621

# Metabolic_Enzyme_19_Theoretical_pI:
9.88

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme activator activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  organic acid metabolism
Process:  carboxylic acid metabolism
Process:  fatty acid metabolism
Process:  icosanoid metabolism
Process:  leukotriene metabolism
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Metabolic_Enzyme_19_General_Function:
Not Available

# Metabolic_Enzyme_19_Specific_Function:
Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione

# Metabolic_Enzyme_19_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_19_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF01124:MAPEG

# Metabolic_Enzyme_19_Signals:
1-23

# Metabolic_Enzyme_19_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_19_GenBank_ID_Protein:
1747521

# Metabolic_Enzyme_19_SwissProt_ID:
MGST2_HUMAN (Q99735)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
MGST2

# Metabolic_Enzyme_19_Geneatlas_id:
MGST2

# Metabolic_Enzyme_19_hgnc_id:
HGNC:7063

# Metabolic_Enzyme_19_PDB_ID:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential)

# Metabolic_Enzyme_19_Gene_Sequence:
>444 bp
ATGGCCGGGAACTCGATCCTGCTGGCTGCTGTCTCTATTCTCTCGGCCTGTCAGCAAAGT
TATTTTGCTTTGCAAGTTGGAAAGGCAAGATTAAAATACAAAGTTACGCCCCCAGCAGTC
ACTGGGTCACCAGAGTTTGAGAGAGTATTTCGGGCACAACAAAACTGTGTGGAGTTTTAT
CCTATATTCATAATTACATTGTGGATGGCTGGGTGGTATTTCAACCAAGTTTTTGCTACT
TGTCTGGGTCTGGTGTACATATATGGCCGTCACCTATACTTCTGGGGATATTCAGAAGCT
GCTAAAAAACGGATCACCGGTTTCCGACTGAGTCTGGGGATTTTGGCCTTGTTGACCCTC
CTAGGTGCCCTGGGAATTGCAAACAGCTTTCTGGATGAATATCTGGACCTCAATATTGCC
AAGAAACTGAGGCGGCAATTCTAA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
U77604

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_19_Locus:
4q28.3

# Metabolic_Enzyme_19_SNPs:
rs8192111; rs8192098; rs2132845; rs809468; rs925424; rs2646076; rs2602243; rs2602238; rs2646051; rs795589; rs2646077; rs706349; rs795593; rs2646035; rs795594; rs706350; rs7664313; rs8192024; rs795590; rs1587265; rs1027473; rs2320532; rs2132846; rs795592; rs7664138; rs814273; rs2874293; rs2132847; rs813973; rs4241932; rs2874294; rs3822045; rs2646074; rs4147590; rs2602241; rs795599; rs795588; rs4863672; rs2173207; rs814272; rs1000222; rs2602240; rs2646075; rs2646067; rs795591; rs8192099; rs13130858; rs1087784; rs795597; rs4863670; rs1453135; rs7671498; rs2646066; rs8192020; rs8192015; rs8192060; rs8192040; rs795598; rs808511; rs8192057; rs2646073; rs8192021; rs1377382; rs4863671; rs1566143; rs3822044; rs8192010; rs8192049; rs4147586; rs8192100; rs8192031; rs8192013; rs8192018; rs9998395; rs2602239; rs8192090; rs2874231; rs8192047; rs8192075; rs8192081; rs7667009; rs8192073; rs8192033; rs8192038; rs8192043; rs8192025; rs8192092; rs8192088; rs11937984; rs795595; rs12506320; rs8192070; rs8192102; rs8192042; rs8192011; rs8192106; rs8192091; rs8192039; rs8192112; rs2262377; rs924198; rs8192065; rs8192087; rs8192028; rs8192066; rs8192008; rs795596; rs8192035; rs34414569; rs8192072; rs8192069; rs8192083; rs8192064; rs8192086; rs8192036; rs2249398; rs8192027; rs8192041; rs8192022; rs8192034; rs8192104; rs8192094; rs8192032; rs8192026; rs8192012; rs813836; rs8192074; rs8192096; rs8192006; rs2602249; rs8192105; rs8192089; rs8192079; rs8192093; rs8192068; rs3775242; rs8192023; rs13124794; rs1877237; rs8192113; rs8191997; rs795600; rs8191998; rs8191999; rs8192002; rs8192000; rs8192004; rs1804766; rs3191370; rs1051012; rs34999217; rs2646065; rs13133710; rs2646050; rs8192080; rs28734878; rs8192095; rs36037692; rs34915408; rs34222679; rs2646045; rs33930474; rs13131383; rs4863673; rs8192084; rs6148690; rs8192009; rs6834931; rs35523969; rs8192078; rs35584892; rs8192030; rs3841989; rs4863674; rs8192061; rs35936725; rs17050860; rs6832986; rs8192103; rs34093279; rs8192048; rs35416623; rs2602242; rs17285463; rs8192014; rs35111803; rs8192019; rs6842145; rs8192052; rs35174024; rs2320531; rs11451296; rs958186; rs2646047; rs34805221; rs8192058; rs35829454; rs8192077; rs1377381; rs28750421; rs8192082; rs2602253; rs8192007; rs8192067; rs5862429; rs2646068; rs34266848; rs35638499; rs28699642; rs35904047; rs8192045; rs3886694; rs4147587; rs35360404; rs8192063; rs34121026; rs2101926; rs34880914; rs35074869; rs33917912; rs8192085; rs8192037; rs2602250; rs8192055; rs3836606; rs8192076; rs2646046; rs8192053; rs28414528; rs10711495; rs35669153; rs2646069; rs8192029; rs8192050; rs8192097; rs34171400; rs33958896; rs8192046; rs34302984; rs8192005; rs8192003; rs8192001; rs8192114; rs8192062; rs12640152; rs12647289; rs1453136; rs17050847; rs17050850; rs17050853; rs17050873; rs17357657; rs1874619; rs345976; rs345977; rs345978; rs35132168; rs3733383; rs3755991; rs3755992; rs3755993; rs3755994; rs3755995; rs3755996; rs3822046; rs4863669; rs4863677; rs7659704; rs7687822; rs795602; rs795605; rs924199; rs924200

# Metabolic_Enzyme_19_General_References:
8703034

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
6103

# Metabolic_Enzyme_20_Name:
Glutathione transferase omega-1

# Metabolic_Enzyme_20_Synonyms:
GSTO 1-1

# Metabolic_Enzyme_20_Gene_Name:
GSTO1

# Metabolic_Enzyme_20_Protein_Sequence:
>Glutathione transferase omega1
MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHEVININLKNKP
EWFFKKNPFGLVPVLENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKMILELF
SKVPSLVGSFIRSQNKEDYAGLKEEFRKEFTKLEEVLTNKKTTFFGGNSISMIDYLIWPW
FERLEAMKLNECVDHTPKLKLWMAAMKEDPTVSALLTSEKDWQGFLELYLQNSPEACDYG
L

# Metabolic_Enzyme_20_Number_of_Residues:
241

# Metabolic_Enzyme_20_Molecular_Weight:
27566

# Metabolic_Enzyme_20_Theoretical_pI:
6.54

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  glutathione transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_20_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_20_Specific_Function:
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities

# Metabolic_Enzyme_20_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_20_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Metabolic_Enzyme_20_Signals:
None

# Metabolic_Enzyme_20_Transmembrane_Regions:
None

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_20_GenBank_ID_Protein:
2393722

# Metabolic_Enzyme_20_SwissProt_ID:
GSTO1_HUMAN (P78417)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
GSTO1

# Metabolic_Enzyme_20_Geneatlas_id:
GSTO1

# Metabolic_Enzyme_20_hgnc_id:
HGNC:13312

# Metabolic_Enzyme_20_PDB_ID:
1EEM

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_20_Gene_Sequence:
>726 bp
ATGTCCGGGGAGTCAGCCAGGAGCTTGGGGAAGGGAAGCGCGCCCCCGGGGCCGGTCCCG
GAGGGCTCGATCCGCATCTACAGCATGAGGTTCTGCCCGTTTGCTGAGAGGACGCGTCTA
GTCCTGAAGGCCAAGGGAATCAGGCATGAAGTCATCAATATCAACCTGAAAAATAAGCCT
GAGTGGTTCTTTAAGAAAAATCCCTTTGGTCTGGTGCCAGTTCTGGAAAACAGTCAGGGT
CAGCTGATCTACGAGTCTGCCATCACCTGTGAGTACCTGGATGAAGCATACCCAGGGAAG
AAGCTGTTGCCGGATGACCCCTATGAGAAAGCTTGCCAGAAGATGATCTTAGAGTTGTTT
TCTAAGGTGCCATCCTTGGTAGGAAGCTTTATTAGAAGCCAAAATAAAGAAGACTATGCT
GGCCTAAAAGAAGAATTTCGTAAAGAATTTACCAAGCTAGAGGAGGTTCTGACTAATAAG
AAGACGACCTTCTTTGGTGGCAATTCTATCTCTATGATTGATTACCTCATCTGGCCCTGG
TTTGAACGGCTGGAAGCAATGAAGTTAAATGAGTGTGTAGACCACACTCCAAAACTGAAA
CTGTGGATGGCAGCCATGAAGGAAGATCCCACAGTCTCAGCCCTGCTTACTAGTGAGAAA
GACTGGCAAGGTTTCCTAGAGCTCTACTTACAGAACAGCCCTGAGGCCTGTGACTATGGG
CTCTGA

# Metabolic_Enzyme_20_GenBank_ID_Gene:
U90313

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_20_Locus:
10q25.1

# Metabolic_Enzyme_20_SNPs:
rs4925; rs11509437; rs7906559; rs7906892; rs7096068; rs7099492; rs7077787; rs10883990; rs2282326; rs7077635; rs12263834; rs11509435; rs12571959; rs1147611; rs17116753; rs7077797; rs11593060; rs6584591; rs12259337; rs7083244; rs7077729; rs17116736; rs7101149; rs7906957; rs12264196; rs7077259; rs12244332; rs12253132; rs12256096; rs11817274; rs17883344; rs7083465; rs7083006; rs17116751; rs12264557; rs12266944; rs12241913; rs12253067; rs11191979; rs12257050; rs7100871; rs12258262; rs7083390; rs597366; rs17116741; rs17883384; rs2164624; rs610917; rs17883150; rs17885679; rs17883111; rs11191975; rs11509436; rs1804834; rs10565172; rs35155165; rs35874137; rs12253203; rs12250910; rs35181287; rs17885934; rs36008966; rs35127427; rs12256999; rs629771; rs17884170; rs11315069; rs17885859; rs11191977; rs35356947; rs12243401; rs12250592; rs17885241; rs35776315; rs34670895; rs34936106; rs35184566; rs35764157; rs35517782; rs594471; rs17881078; rs12250833; rs17880435; rs17881537; rs17881115; rs11191976; rs7923810; rs12569899; rs11191978; rs12220137; rs34521730; rs11315070; rs35856923; rs10565171; rs17884376; rs17879741; rs628480; rs35075876; rs17881389; rs1045505; rs10491045; rs10509769; rs11191970; rs11191972; rs11191973; rs11191980; rs11191982; rs11191983; rs11191984; rs11191985; rs11191986; rs11191987; rs11509438; rs11509439; rs11812790; rs12247206; rs12251225; rs12261808; rs12262175; rs12264646; rs12264844; rs12267156; rs12571655; rs12773129; rs15032; rs17116726; rs17116729; rs17116754; rs17116755; rs17116758; rs17116770; rs17116779; rs17116783; rs17116784; rs17116785; rs17116786; rs17826034; rs2297235; rs276204; rs2902641; rs3211015; rs34265126; rs34400162; rs494431; rs568526; rs589007; rs637008; rs693873; rs7070750; rs7074170; rs7089730; rs7589; rs7896341; rs7896809; rs7897376; rs7910156; rs7913632; rs7914492; rs966645

# Metabolic_Enzyme_20_General_References:
10783391; 12928150; 11271497; 12618591

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
5428

# Metabolic_Enzyme_21_Name:
Glutathione reductase, mitochondrial precursor

# Metabolic_Enzyme_21_Synonyms:
GR; GRase

# Metabolic_Enzyme_21_Gene_Name:
GSR

# Metabolic_Enzyme_21_Protein_Sequence:
>Glutathione reductase, mitochondrial precursor
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK
TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD
EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR

# Metabolic_Enzyme_21_Number_of_Residues:
522

# Metabolic_Enzyme_21_Molecular_Weight:
56258

# Metabolic_Enzyme_21_Theoretical_pI:
8.66

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  disulfide oxidoreductase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  FAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  transporter activity
Function:  electron transporter activity
Function:  glutathione-disulfide reductase activity
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  electron transport
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  cofactor metabolism
Process:  coenzyme metabolism
Process:  glutathione metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_21_General_Function:
RNA processing and modification 

# Metabolic_Enzyme_21_Specific_Function:
Maintains high levels of reduced glutathione in the cytosol

# Metabolic_Enzyme_21_Pathway:
map00251  Glutamate metabolism;
 map00480  Glutathione metabolism

# Metabolic_Enzyme_21_Reaction:
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF00070:Pyr_redox;
PF07992:Pyr_redox_2;
PF02852:Pyr_redox_dim

# Metabolic_Enzyme_21_Signals:
1-37

# Metabolic_Enzyme_21_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 1.8.1.7

# Metabolic_Enzyme_21_GenBank_ID_Protein:
31825

# Metabolic_Enzyme_21_SwissProt_ID:
GSHR_HUMAN (P00390)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
GSR

# Metabolic_Enzyme_21_Geneatlas_id:
GSR

# Metabolic_Enzyme_21_hgnc_id:
HGNC:4623

# Metabolic_Enzyme_21_PDB_ID:
1BWC

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Mitochondrion. Cytoplasm

# Metabolic_Enzyme_21_Gene_Sequence:
>1440 bp
ATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGCGCCGTGGCC
TCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCG
GCCGAGCTGGGTGCCAGGGCCGCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCGTG
AATGTTGGATGTGTACCCAAAAAGGTAATGTGGAACACAGCTGTCCACTCTGAATTCATG
CATGATCATGCTGATTATGGCTTTCCAAGTTGTGAGGGTAAATTCAATTGGCGTGTTATT
AAGGAAAAGCGGGATGCCTATGTGAGCCGCCTGAATGCCATCTATCAAAACAATCTCACC
AAGTCCCATATAGAAATCATCCGTGGCCATGCAGCCTTCACGAGTGATCCCAAGCCCACA
ATAGAGGTCAGTGGGAAAAAGTACACCGCCCCACACATCCTGATCGCCACAGGTGGTATG
CCCTCCACCCCTCATGAGAGCCAGATCCCCGGTGCCAGCTTAGGAATAACCAGCGATGGA
TTTTTTCAGCTGGAAGAATTGCCCGGCCGCAGCGTCATTGTTGGTGCAGGTTACATTGCT
GTGGAGATGGCAGGGATCCTGTCAGCCCTGGGTTCTAAGACATCACTGATGATACGGCAT
GATAAGGTACTTAGAAGTTTTGATTCAATGATCAGCACCAACTGCACGGAGGAGCTGGAG
AACGCTGGCGTGGAGGTGCTGAAGTTCTCCCAGGTCAAGGAGGTTAAAAAGACTTTGTCG
GGCTTGGAAGTCAGCATGGTTACTGCAGTTCCCGGTAGGCTACCAGTCATGACCATGATT
CCAGATGTTGACTGCCTGCTCTGGGCCATTGGGCGGGTCCCGAATACCAAGGACCTGAGT
TTAAACAAACTGGGGATTCAAACCGATGACAAGGGTCATATCATCGTAGACGAATTCCAG
AATACCAACGTCAAAGGCATCTATGCAGTTGGGGATGTATGTGGAAAAGCTCTTCTTACT
CCAGTTGCAATAGCTGCTGGCCGAAAACTTGCCCATCGACTTTTTGAATATAAGGAAGAT
TCCAAATTAGATTATAACAACATCCCAACTGTGGTCTTCAGCCACCCCCCTATTGGGACA
GTGGGACTCACGGAAGATGAAGCCATTCATAAATATGGAATAGAAAATGTGAAGACCTAT
TCAACGAGCTTTACCCCGATGTATCACGCAGTTACCAAAAGGAAAACAAAATGTGTGATG
AAAATGGTCTGTGCTAACAAGGAAGAAAAGGTGGTTGGGATCCATATGCAGGGACTTGGG
TGTGATGAAATGCTGCAGGGTTTTGCTGTTGCAGTGAAGATGGGAGCAACGAAGGCAGAC
TTTGACAACACAGTCGCCATTCACCCTACCTCTTCAGAAGAGCTGGTCACACTTCGTTGA


# Metabolic_Enzyme_21_GenBank_ID_Gene:
X15722

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_21_Locus:
8p21.1

# Metabolic_Enzyme_21_SNPs:
rs8190955; rs2020916; rs8190976; rs2280854; rs2280855; rs8191005; rs8190881; rs1554991; rs8191039; rs1138054; rs8191040; rs2911670; rs2551696; rs2551715; rs2253409; rs2911669; rs2739008; rs2161850; rs10088455; rs2978295; rs8190896; rs2551702; rs7818511; rs1125853; rs10094209; rs3779647; rs2250192; rs2738973; rs2978663; rs2161849; rs8190927; rs2343688; rs8190983; rs8191025; rs2551724; rs2472219; rs3779648; rs3757918; rs2978297; rs8190966; rs2551708; rs2739002; rs2280857; rs2251780; rs8190986; rs2978670; rs8190887; rs2978667; rs1465478; rs8190917; rs8190894; rs8191003; rs2911674; rs8190898; rs2551710; rs2551698; rs4628224; rs2551707; rs2911676; rs8190968; rs8190943; rs2280856; rs3757917; rs8190892; rs8190996; rs2956007; rs8191030; rs2739004; rs7832572; rs6996579; rs8190890; rs8190907; rs2880679; rs2911673; rs8190886; rs7827120; rs7007803; rs16877292; rs8191019; rs2978298; rs8190987; rs2113525; rs2978662; rs8190893; rs2978296; rs3926402; rs2551732; rs17557435; rs11992338; rs8190948; rs8190945; rs2978669; rs2551706; rs2113524; rs11992081; rs8191038; rs8190930; rs12678167; rs8190919; rs8190891; rs8190910; rs8190904; rs8190969; rs7817288; rs8190925; rs8191031; rs2472220; rs2955993; rs2911668; rs8191023; rs8190923; rs8190906; rs8190900; rs8191018; rs2978303; rs12543353; rs8190922; rs8190994; rs2467539; rs8190949; rs2978665; rs889926; rs8190889; rs8191016; rs8191029; rs8190972; rs8191008; rs8191027; rs2739012; rs8190981; rs16877293; rs2249404; rs8191022; rs11774927; rs8191035; rs8190992; rs1318983; rs8190991; rs2978671; rs2911678; rs2551700; rs8190933; rs4377922; rs8190911; rs8190973; rs8191028; rs8190946; rs8191017; rs8190914; rs2978666; rs2551699; rs2739011; rs8190967; rs8190924; rs8191033; rs8190954; rs8190918; rs13259611; rs8190908; rs8190901; rs8190975; rs8190944; rs8191006; rs2551697; rs8191010; rs2472221; rs8191026; rs8190902; rs2911675; rs2911672; rs8190895; rs13279565; rs8190937; rs8191013; rs8190888; rs8190988; rs1465479; rs2161848; rs10088303; rs2467538; rs8190897; rs8190951; rs8190939; rs8191037; rs8190970; rs8191036; rs2551726; rs1465477; rs8191009; rs8190899; rs8190926; rs8190958; rs2739013; rs8190982; rs4733505; rs3594; rs1002149; rs2280853; rs2280852; rs1138107; rs2955996; rs1973874; rs8190877; rs8191042; rs1968278; rs1985176; rs8190878; rs8191043; rs8190997; rs3180947; rs34855738; rs3180950; rs8190884; rs8191004; rs3180949; rs3180948; rs8190883; rs11552962; rs926171; rs2551733; rs8191041; rs8190882; rs35768151; rs1138052; rs926172; rs926170; rs10216724; rs35555269; rs13251135; rs28503477; rs8190977; rs8190999; rs8191020; rs1318334; rs8190913; rs28653003; rs7011849; rs28551481; rs8190984; rs2739010; rs2738994; rs2739000; rs8190990; rs2551716; rs8191007; rs34877158; rs2956006; rs8190921; rs2738984; rs2738981; rs2472215; rs8190950; rs11461103; rs2978661; rs2551731; rs10608990; rs3077097; rs11781803; rs2955990; rs34421060; rs961267; rs28659928; rs2467548; rs8190963; rs28510299; rs10635942; rs28452359; rs2738978; rs2551720; rs2467545; rs36079387; rs909351; rs8190915; rs8190957; rs10679532; rs35922361; rs35385906; rs12681084; rs2551718; rs11316943; rs34274967; rs8190885; rs8191015; rs3779646; rs8190964; rs2472217; rs2738986; rs2551729; rs10649702; rs2472212; rs34724930; rs13253409; rs2738982; rs2738992; rs8190932; rs2978302; rs2303343; rs2551722; rs11386943; rs10090296; rs8190974; rs2978290; rs8190941; rs8191011; rs1473673; rs2738990; rs7831264; rs8190971; rs2738983; rs34353898; rs8190965; rs7007798; rs35029937; rs34815510; rs2472214; rs1965590; rs2472218; rs9773264; rs34205548; rs34380214; rs2738998; rs7830949; rs2955995; rs2551727; rs2467547; rs34342136; rs28548706; rs2467543; rs2738975; rs8190934; rs7461403; rs28452748; rs8191024; rs34774713; rs11386939; rs35464878; rs34789848; rs8190931; rs10715710; rs34873265; rs11299063; rs11364879; rs2472216; rs35456447; rs2467537; rs2551721; rs8190998; rs28414905; rs8190952; rs34476341; rs2738996; rs2738976; rs36213901; rs33969377; rs2551704; rs2911679; rs36066856; rs36069113; rs2956005; rs2551717; rs34704939; rs8190912; rs8190903; rs8191014; rs2551725; rs8191001; rs1599947; rs8190936; rs28649502; rs5890532; rs1465102; rs8190905; rs2551711; rs2738985; rs28489542; rs2467544; rs2955991; rs7816217; rs2738993; rs35594378; rs2739007; rs2551730; rs2467549; rs8190962; rs2738995; rs35866628; rs6982734; rs36063576; rs8190938; rs2738979; rs2551719; rs3110091; rs2911671; rs2739009; rs11785352; rs35320606; rs34590858; rs34423117; rs36035324; rs35272936; rs10584054; rs34649346; rs2551709; rs34123148; rs8190985; rs35944160; rs2738987; rs35345657; rs8190920; rs16877277; rs34180062; rs35356298; rs13258442; rs2551723; rs35823823; rs2978301; rs8190935; rs10102510; rs34885609; rs35706621; rs28707724; rs10106746; rs8191032; rs2551703; rs8190989; rs2739001; rs13268496; rs2551712; rs2738989; rs33969608; rs2955994; rs34889409; rs28641651; rs8190961; rs34676475; rs34141675; rs2738972; rs2738988; rs2738999; rs35052620; rs8190953; rs8191002; rs34390863; rs35321123; rs909352; rs35206861; rs2343687; rs28517564; rs8191012; rs8190916; rs8190980; rs8191034; rs16877266; rs2738974; rs2739003; rs8190940; rs34302748; rs2738980; rs8190956; rs8191021; rs2551705; rs2956004; rs2978305; rs11347956; rs2911677; rs2978664; rs2551714; rs2738997; rs2467546; rs8191000; rs2738991; rs35132121; rs7461402; rs2738977; rs36076894; rs8190979; rs5890533; rs10704685; rs2551701; rs1318333; rs35866797; rs8190942; rs10629215; rs8190929; rs2467536; rs2472213; rs7012340; rs12547563; rs13250209; rs28532763; rs2551735; rs11552960; rs11552964; rs14203; rs34396322; rs2551738; rs3201906; rs36124241; rs7357427; rs8190880; rs11552958; rs1138117; rs2911680; rs1973873; rs8190879; rs2955998; rs2551734; rs10634282; rs11552957; rs11552961; rs1138092; rs11552955; rs34431739; rs10558838; rs10652997; rs2551736; rs2551739; rs1138089; rs11552954; rs2551737; rs35938308; rs2978668; rs8190876; rs34067868; rs10283288; rs11986256; rs12541868; rs13249468; rs2161847; rs2978304; rs6987913

# Metabolic_Enzyme_21_General_References:
2185014; 10708558; 7060551; 923580; 7334521; 3656429; 8626496; 9174360; 9546215

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
6104

# Metabolic_Enzyme_22_Name:
Glutathione S-transferase A5

# Metabolic_Enzyme_22_Synonyms:
Glutathione S-transferase A5-5; GST class-alpha member 5

# Metabolic_Enzyme_22_Gene_Name:
GSTA5

# Metabolic_Enzyme_22_Protein_Sequence:
>Glutathione Stransferase A5
MAEKPKLHYSNARGSMESIRWLLAAAGVELEEKFLESAEDLDKLRNDGSLLFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDMKERALIDMYTEGIVDLTEMILLLLICQPEERDAK
TALVKEKIKNRYFPAFEKVLKSHRQDYLVGNKLSWADIHLVELFYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSQRKPPMDEKSLEEARKIFRF

# Metabolic_Enzyme_22_Number_of_Residues:
222

# Metabolic_Enzyme_22_Molecular_Weight:
25722

# Metabolic_Enzyme_22_Theoretical_pI:
8.37

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  glutathione transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Not Available

# Metabolic_Enzyme_22_Specific_Function:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_22_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_22_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Metabolic_Enzyme_22_Signals:
None

# Metabolic_Enzyme_22_Transmembrane_Regions:
None

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_22_GenBank_ID_Protein:
23197582

# Metabolic_Enzyme_22_SwissProt_ID:
GSTA5_HUMAN (Q7RTV2)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
GSTA5

# Metabolic_Enzyme_22_Geneatlas_id:
GSTA5

# Metabolic_Enzyme_22_hgnc_id:
HGNC:19662

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_22_Gene_Sequence:
>669 bp
ATGGCAGAGAAGCCCAAGCTCCACTACTCCAATGCACGGGGCAGTATGGAGTCCATTCGG
TGGCTCCTGGCTGCAGCTGGAGTAGAGTTGGAAGAGAAATTTCTAGAATCTGCAGAAGAT
TTGGACAAGTTAAGAAATGATGGGAGTTTGCTGTTCCAGCAAGTACCAATGGTTGAGATT
GACGGGATGAAGCTGGTGCAGACCAGAGCCATTCTTAACTACATTGCCAGCAAATACAAC
CTTTATGGGAAAGACATGAAGGAGAGAGCCCTGATTGATATGTACACAGAAGGTATAGTA
GATTTGACTGAAATGATCCTTCTTCTGCTCATATGTCAACCAGAGGAAAGAGATGCCAAG
ACTGCCTTGGTCAAAGAGAAAATAAAAAATCGCTACTTCCCTGCCTTTGAAAAAGTCTTA
AAGAGCCACAGACAAGACTACCTTGTTGGCAACAAGCTGAGCTGGGCTGACATTCACCTG
GTGGAACTTTTCTACTACGTGGAAGAGCTTGACTCGAGTCTTATCTCCAGCTTCCCTCTG
CTGAAGGCCCTGAAAACCAGAATCAGCAACCTGCCCACGGTGAAGAAGTTTCTGCAGCCT
GGCAGCCAGAGAAAGCCTCCCATGGATGAGAAATCTTTAGAAGAAGCAAGGAAGATTTTC
AGGTTTTAA

# Metabolic_Enzyme_22_GenBank_ID_Gene:
BK000212

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_22_Locus:
6p12.1

# Metabolic_Enzyme_22_SNPs:
Not Available

# Metabolic_Enzyme_22_General_References:
14574404; 12042665

# Metabolic_Enzyme_22_References:
Not Available

# Metabolic_Enzyme_23_ID:
5629

# Metabolic_Enzyme_23_Name:
Lactoylglutathione lyase

# Metabolic_Enzyme_23_Synonyms:
Methylglyoxalase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; S-D- lactoylglutathione methylglyoxal lyase

# Metabolic_Enzyme_23_Gene_Name:
GLO1

# Metabolic_Enzyme_23_Protein_Sequence:
>Lactoylglutathione lyase
MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQK
CDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNS
DPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKM
ATLM

# Metabolic_Enzyme_23_Number_of_Residues:
184

# Metabolic_Enzyme_23_Molecular_Weight:
20778

# Metabolic_Enzyme_23_Theoretical_pI:
4.92

# Metabolic_Enzyme_23_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-sulfur lyase activity
Function:  lactoylglutathione lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_23_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_23_Specific_Function:
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione

# Metabolic_Enzyme_23_Pathway:
map00620  Pyruvate metabolism

# Metabolic_Enzyme_23_Reaction:
(R)-S-lactoylglutathione = glutathione + methylglyoxal

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF00903:Glyoxalase

# Metabolic_Enzyme_23_Signals:
None

# Metabolic_Enzyme_23_Transmembrane_Regions:
None

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 4.4.1.5

# Metabolic_Enzyme_23_GenBank_ID_Protein:
219664

# Metabolic_Enzyme_23_SwissProt_ID:
LGUL_HUMAN (Q04760)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
GLO1

# Metabolic_Enzyme_23_Geneatlas_id:
GLO1

# Metabolic_Enzyme_23_hgnc_id:
HGNC:4323

# Metabolic_Enzyme_23_PDB_ID:
1QIP

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Not Available

# Metabolic_Enzyme_23_Gene_Sequence:
>555 bp
ATGGCAGAACCGCAGCCCCCGTCCGGCGGCCTCACGGACGAGGCCGCCCTCAGTTGCTGC
TCCGACGCGGACCCCAGTACCAAGGATTTTCTATTGCAGCAGACCATGCTACGAGTGAAG
GATCCTAAGAAGTCACTGGATTTTTATACTAGAGTTCTTGGAATGACGCTAATCCAAAAA
TGTGATTTTCCCATTATGAAGTTTTCACTCTACTTCTTGGCTTATGAGGATAAAAATGAC
ATCCCTAAAGAAAAAGATGAAAAAATAGCCTGGGCGCTCTCCAGAAAAGCTACACTTGAG
CTGACACACAATTGGGGCACTGAAGATGATGCGACCCAGAGTTACCACAATGGCAATTCA
GACCCTCGAGGATTCGGTCATATTGGAATTGCTGTTCCTGATGTATACAGTGCTTGTAAA
AGGTTTGAAGAACTGGGAGTCAAATTTGTGAAGAAACCTGATGATGGTAAAATGAAAGGC
CTGGCATTTATTCAAGATCCTGATGGCTACTGGATTGAAATTTTGAATCCTAACAAAATG
GCAACCTTAATGTAG

# Metabolic_Enzyme_23_GenBank_ID_Gene:
D13315

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_23_Locus:
6p21.3-p21.1

# Metabolic_Enzyme_23_SNPs:
Not Available

# Metabolic_Enzyme_23_General_References:
7684374; 8449929; 8670058; 10564821; 14574404; 9218781; 9705294; 10521255

# Metabolic_Enzyme_23_References:
Not Available

# Metabolic_Enzyme_24_ID:
6105

# Metabolic_Enzyme_24_Name:
Glutathione S-transferase A2

# Metabolic_Enzyme_24_Synonyms:
GTH2; HA subunit 2; GST- gamma; GSTA2-2; GST class-alpha member 2

# Metabolic_Enzyme_24_Gene_Name:
GSTA2

# Metabolic_Enzyme_24_Protein_Sequence:
>Glutathione Stransferase A2
MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKEKALIDMYIEGIADLGEMILLLPFSQPEEQDAK
LALIQEKTKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEESRKIFRF

# Metabolic_Enzyme_24_Number_of_Residues:
222

# Metabolic_Enzyme_24_Molecular_Weight:
25664

# Metabolic_Enzyme_24_Theoretical_pI:
9.07

# Metabolic_Enzyme_24_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  glutathione transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_24_General_Function:
Not Available

# Metabolic_Enzyme_24_Specific_Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

# Metabolic_Enzyme_24_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_24_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_24_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Metabolic_Enzyme_24_Signals:
None

# Metabolic_Enzyme_24_Transmembrane_Regions:
None

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_24_GenBank_ID_Protein:
306811

# Metabolic_Enzyme_24_SwissProt_ID:
GSTA2_HUMAN (P09210)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
GSTA2

# Metabolic_Enzyme_24_Geneatlas_id:
GSTA2

# Metabolic_Enzyme_24_hgnc_id:
HGNC:4627

# Metabolic_Enzyme_24_PDB_ID:
1AGS

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_24_Gene_Sequence:
>669 bp
ATGGCAGAGAAGCCCAAGCTCCACTACTCCAATATACGGGGCAGAATGGAGTCCATCCGG
TGGCTCCTGGCTGCAGCTGGAGTAGAGTTTGAAGAGAAATTTATAAAATCTGCAGAAGAT
TTGGACAAGTTAAGAAATGATGGATATTTGATGTTCCAGCAAGTGCCAATGGTTGAGATT
GATGGGATGAAGCTGGTGCAGACCAGAGCCATTCTCAACTACATTGCCAGCAAATACAAC
CTCTATGGGAAAGACATAAAGGAGAAAGCCCTGATTGATATGTATATAGAAGGTATAGCA
GATTTGGGTGAAATGATCCTTCTTCTGCCCTTTACTCAACCTGAGGAACAAGATGCCAAG
CTTGCCTTGATCCAAGAGAAAACAAAAAATCGCTACTTCCCTGCCTTTGAAAAAGTCTTA
AAGAGCCACGGACAAGACTACCTTGTTGGCAACAAGCTGAGCCGGGCTGACATTCACCTG
GTGGAACTTCTCTACTACGTGGAAGAGCTTGACTCTAGCCTTATTTCCAGCTTCCCTCTG
CTGAAGGCCCTGAAAACCAGAATCAGTAACCTGCCCACAGTGAAGAAGTTTCTACAGCCT
GGCAGCCCAAGGAAGCCTCCCATGGATGAGAAATCTTTAGAAGAATCAAGGAAGATTTTC
AGGTTTTAA

# Metabolic_Enzyme_24_GenBank_ID_Gene:
M16594

# Metabolic_Enzyme_24_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_24_Locus:
6p12.1

# Metabolic_Enzyme_24_SNPs:
Not Available

# Metabolic_Enzyme_24_General_References:
3036131; 1329668; 1497629; 14574404; 8431482; 2604726; 11668220

# Metabolic_Enzyme_24_References:
Not Available

# Metabolic_Enzyme_25_ID:
6106

# Metabolic_Enzyme_25_Name:
Glutathione peroxidase 6 precursor

# Metabolic_Enzyme_25_Synonyms:
Not Available

# Metabolic_Enzyme_25_Gene_Name:
GPX6

# Metabolic_Enzyme_25_Protein_Sequence:
>Glutathione peroxidase 6 precursor
MFQQFQASCLVLFFLVGFAQQTLKPQNRKVDCNKGVTGTIYEYGALTLNGEEYIQFKQFA
GKHVLFVNVAAYCGLAAQYPELNALQEELKNFGVIVLAFPCNQFGKQEPGTNSEILLGLK
YVCPGSGFVPSFQLFEKGDVNGEKEQKVFTFLKNSCPPTSDLLGSSSQLFWEPMKVHDIR
WNFEKFLVGPDGVPVMHWFHQAPVSTVKSDILEYLKQFNTH

# Metabolic_Enzyme_25_Number_of_Residues:
221

# Metabolic_Enzyme_25_Molecular_Weight:
24924

# Metabolic_Enzyme_25_Theoretical_pI:
6.66

# Metabolic_Enzyme_25_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  glutathione peroxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_25_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_25_Specific_Function:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O

# Metabolic_Enzyme_25_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_25_Reaction:
2 glutathione + H2O2 = glutathione disulfide + 2 H2O

# Metabolic_Enzyme_25_Pfam_Domain_Function:
PF00255:GSHPx

# Metabolic_Enzyme_25_Signals:
1-19

# Metabolic_Enzyme_25_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_25_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_25_EC_Link:
EC 1.11.1.9

# Metabolic_Enzyme_25_GenBank_ID_Protein:
32492913

# Metabolic_Enzyme_25_SwissProt_ID:
GPX6_HUMAN (P59796)

# Metabolic_Enzyme_25_swissprot_Name:
Not Available

# Metabolic_Enzyme_25_Genecard_id:
GPX6

# Metabolic_Enzyme_25_Geneatlas_id:
GPX6

# Metabolic_Enzyme_25_hgnc_id:
HGNC:4558

# Metabolic_Enzyme_25_PDB_ID:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_25_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_25_Gene_Sequence:
>666 bp
ATGTTCCAGCAGTTCCAGGCCTCCTGTCTTGTCCTGTTTTTCCTGGTTGGCTTTGCTCAG
CAGACCCTAAAGCCTCAAAATAGGAAGGTGGATTGCAACAAAGGGGTAACAGGCACCATC
TATGAGTATGGAGCCCTCACCCTCAACGGCGAGGAGTACATCCAATTCAAGCAGTTTGCA
GGCAAGCACGTCCTGTTTGTCAATGTGGCCGCCTATTGAGGCTTGGCAGCTCAGTATCCT
GAACTGAATGCACTACAGGAGGAGCTGAAGAATTTTGGTGTCATTGTGTTGGCCTTTCCC
TGCAACCAGTTTGGAAAACAAGAACCAGGAACAAACTCAGAAATACTTCTTGGTCTCAAG
TATGTGTGTCCAGGTAGTGGCTTTGTCCCCAGTTTCCAGCTCTTTGAGAAAGGGGATGTG
AATGGAGAAAAAGAACAGAAGGTCTTTACTTTCCTGAAGAACTCCTGCCCTCCGACCTCT
GATCTTTTGGGCTCATCAAGCCAACTCTTCTGGGAGCCCATGAAGGTCCATGATATCCGC
TGGAACTTTGAGAAATTTCTGGTGGGGCCCGATGGAGTCCCTGTCATGCATTGGTTCCAC
CAGGCTCCAGTCAGCACAGTCAAGTCAGACATCCTGGAGTACCTAAAGCAGTTCAATACC
CACTAG

# Metabolic_Enzyme_25_GenBank_ID_Gene:
AY324826

# Metabolic_Enzyme_25_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_25_Locus:
6p22.1

# Metabolic_Enzyme_25_SNPs:
Not Available

# Metabolic_Enzyme_25_General_References:
12775843

# Metabolic_Enzyme_25_References:
Not Available

# Metabolic_Enzyme_26_ID:
6071

# Metabolic_Enzyme_26_Name:
Glutathione synthetase

# Metabolic_Enzyme_26_Synonyms:
Glutathione synthase; GSH synthetase; GSH-S

# Metabolic_Enzyme_26_Gene_Name:
GSS

# Metabolic_Enzyme_26_Protein_Sequence:
>Glutathione synthetase
MATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSA
LLEQAYAVQMDFNLLVDAVSQNAAFLEQTLSSTIKQDDFTARLFDIHKQVLKEGIAQTVF
LGLNRSDYMFQRSADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLSKTKEAGKIL
SNNPSKGLALGIAKAWELYGSPNALVLLIAQEKERNIFDQRAIENELLARNIHVIRRTFE
DISEKGSLDQDRRLFVDGQEIAVVYFRDGYMPRQYSLQNWEARLLLERSHAAKCPDIATQ
LAGTKKVQQELSRPGMLEMLLPGQPEAVARLRATFAGLYSLDVGEEGDQAIAEALAAPSR
FVLKPQREGGGNNLYGEEMVQALKQLKDSEERASYILMEKIEPEPFENCLLRPGSPARVV
QCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYPV

# Metabolic_Enzyme_26_Number_of_Residues:
474

# Metabolic_Enzyme_26_Molecular_Weight:
52385

# Metabolic_Enzyme_26_Theoretical_pI:
5.73

# Metabolic_Enzyme_26_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  acid-amino acid ligase activity
Function:  glutathione synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  cofactor metabolism
Process:  coenzyme metabolism
Process:  glutathione metabolism
Process:  glutathione biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_26_General_Function:
Not Available

# Metabolic_Enzyme_26_Specific_Function:
ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione

# Metabolic_Enzyme_26_Pathway:
map00251  Glutamate metabolism;
 map00480  Glutathione metabolism

# Metabolic_Enzyme_26_Reaction:
ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione

# Metabolic_Enzyme_26_Pfam_Domain_Function:
PF03917:GSH_synth_ATP;
PF03199:GSH_synthase

# Metabolic_Enzyme_26_Signals:
None

# Metabolic_Enzyme_26_Transmembrane_Regions:
None

# Metabolic_Enzyme_26_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_26_EC_Link:
EC 6.3.2.3

# Metabolic_Enzyme_26_GenBank_ID_Protein:
886284

# Metabolic_Enzyme_26_SwissProt_ID:
GSHB_HUMAN (P48637)

# Metabolic_Enzyme_26_swissprot_Name:
Not Available

# Metabolic_Enzyme_26_Genecard_id:
GSS

# Metabolic_Enzyme_26_Geneatlas_id:
GSS

# Metabolic_Enzyme_26_hgnc_id:
HGNC:4624

# Metabolic_Enzyme_26_PDB_ID:
2HGS

# Metabolic_Enzyme_26_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_26_Subcellular_Location:
Not Available

# Metabolic_Enzyme_26_Gene_Sequence:
>1425 bp
ATGGCCACCAACTGGGGGAGCCTCTTGCAGGATAAACAGCAGCTAGAGGAGCTGGCACGG
CAGGCCGTGGACCGGGCCCTGGCTGAGGGAGTATTGCTGAGGACCTCACAGGAGCCCACT
TCCTCGGAGGTGGTGAGCTATGCCCCATTCACGCTCTTCCCCTCACTGGTCCCCAGTGCC
CTGCTGGAGCAAGCCTATGCTGTGCAGATGGACTTCAACCTGCTAGTGGATGCTGTCAGC
CAGAACGCTGCCTTCCTGGAGCAAACTCTTTCCAGCACCATCAAACAGGATGACTTTACC
GCTCGTCTCTTTGACATCCACAAGCAAGTCCTAAAAGAGGGCATTGCCCAGACTGTGTTC
CTGGGCCTGAATCGCTCAGACTACATGTTCCAGCGCAGCGCAGATGGCTCCCCAGCCCTG
AAACAGATCGAAATCAACACCATCTCTGCCAGCTTTGGGGGCCTGGCCTCCCGGACCCCA
GCTGTGCACCGACATGTTCTCAGTGTCCTGAGTAAGACCAAAGAAGCTGGCAAGATCCTC
TCTAATAATCCCAGCAAGGGACTGGCCCTGGGAATTGCCAAAGCCTGGGAGCTCTACGGC
TCACCCAATGCTCTGGTGCTACTGATTGCTCAAGAGAAGGAAAGAAACATATTTGACCAG
CGTGCCATAGAGAATGAGCTACTGGCCAGGAACATCCATGTGATCCGACGAACATTTGAA
GATATCTCTGAAAAGGGGTCTCTGGACCAAGACCGAAGGCTGTTTGTGGATGGCCAGGAA
ATTGCTGTGGTTTACTTCCGGGATGGCTACATGCCTCGTCAGTACAGTCTACAGAATTGG
GAAGCACGTCTACTGCTGGAGAGGTCACATGCTGCCAAGTGCCCAGACATTGCCACCCAG
CTGGCTGGGACTAAGAAGGTGCAGCAGGAGCTAAGCAGGCCGGGCATGCTGGAGATGTTG
CTCCCTGGCCAGCCTGAGGCTGTGGCCCGCCTCCGCGCCACCTTTGCTGGCCTCTACTCA
CTGGATGTGGGTGAAGAAGGGGACCAGGCCATCGCCGAGGCCCTTGCTGCCCCTAGCCGG
TTTGTGCTAAAGCCCCAGAGAGAGGGTGGAGGTAACAACCTATATGGGGAGGAAATGGTA
CAGGCCCTGAAACAGCTGAAGGACAGTGAGGAGAGGGCCTCCTACATCCTCATGGAGAAG
ATCGAACCTGAGCCTTTTGAGAATTGCCTGCTACGGCCTGGCAGCCCTGCCCGAGTGGTC
CAGTGCATTTCAGAGCTGGGCATCTTTGGGGTCTATGTCAGGCAGGAAAAGACACTCGTG
ATGAACAAGCACGTGGGGCATCTACTTCGAACCAAAGCCATCGAGCATGCAGATGGTGGT
GTGGCAGCGGGAGTGGCAGTCCTGGACAACCCATACCCTGTGTGA

# Metabolic_Enzyme_26_GenBank_ID_Gene:
L42531

# Metabolic_Enzyme_26_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_26_Locus:
20q11.2

# Metabolic_Enzyme_26_SNPs:
rs11905938; rs2025096; rs6058146; rs17310328; rs12106012; rs12106084; rs6060128; rs17092185; rs6088660; rs6088659; rs35747685; rs35401456; rs34828551; rs35024451; rs34424190; rs34197261; rs6088658; rs35242933; rs2273684; rs1801310; rs6088655; rs7262107; rs6060124; rs4911452; rs2236270; rs6060127; rs2378261; rs11167248; rs2065003; rs6087653; rs8124933; rs6088653; rs6119545; rs7265992; rs6087652; rs6088657; rs6087651; rs734111; rs2236271; rs17092180; rs6087654; rs6142264; rs34286188; rs34158986; rs35789023; rs35416056; rs34681587; rs34436718; rs35333051; rs34275953; rs8116746; rs34244243; rs36033330; rs35095077; rs35546710; rs35332752; rs34138151; rs11906565; rs35291022; rs6060120; rs35515472; rs34053903; rs34526995; rs34174778; rs35552264; rs35492041; rs7268769; rs3761144; rs35554478; rs13041792; rs35409039; rs11556224; rs28936396; rs34852238; rs34239729; rs35051256; rs2025097; rs6119546; rs6088652; rs35312031; rs36000727; rs35436858; rs34058755; rs34695538; rs4911453; rs4911454; rs1051103; rs6060129; rs36110693; rs36066003; rs35530012; rs34799519; rs1051118; rs9369; rs1063574; rs34120465; rs36088358; rs11483006; rs11479510; rs8118735; rs11426955; rs7363022; rs34843909; rs36089768; rs34585562; rs13044537; rs11429240; rs34687164; rs34781494; rs35865417; rs34018529; rs34600433; rs35351954; rs34897984; rs6120765; rs35986481; rs35660796; rs34606182; rs34739274; rs6088656; rs6141521; rs35132658; rs6060125; rs34457683; rs35595300; rs7343400; rs36066117; rs11433142; rs13039821; rs6060122; rs35990489; rs35898203; rs11411767; rs13040526; rs34209721; rs41303799; rs6058145; rs34632033; rs11453665; rs34669462; rs35600676; rs34315595; rs35487260; rs6087655; rs35228406; rs6060121; rs35270925; rs34436391; rs34233448; rs34331049; rs35878299; rs7344898; rs6120766; rs35928385; rs11349896; rs11413498; rs35607184; rs7351715; rs6058144; rs33967485; rs35188973; rs34041698; rs6142265; rs34006566; rs35274316; rs11482121; rs34433793; rs36048676; rs7264920; rs12162462; rs34413947; rs13040393; rs35405069; rs6088654; rs6120767; rs35147036; rs34526380; rs36021884; rs35794011; rs13044412; rs35294917; rs7266596; rs35285939; rs35976778; rs3787212; rs13036630; rs6087656; rs36208521; rs34293667; rs36208864; rs35828152; rs34864006; rs11700037; rs10427424; rs10427446; rs10485507; rs11699241; rs11905995; rs17092174; rs17309872; rs17310467; rs17401737; rs2076667; rs2223881; rs2378263; rs3746450; rs3761143; rs3818273; rs4911165; rs4911449; rs4911450; rs4911451; rs6058147; rs6060130; rs6088649; rs6088650; rs6088651; rs6088662; rs6088663; rs6088664; rs6119547; rs6120764; rs6120768; rs6141522; rs6142263; rs725521; rs7260994; rs8119110; rs8183627

# Metabolic_Enzyme_26_General_References:
7646467; 11780052; 8896573; 9215686

# Metabolic_Enzyme_26_References:
Not Available

# Metabolic_Enzyme_27_ID:
6107

# Metabolic_Enzyme_27_Name:
Glutathione S-transferase A3

# Metabolic_Enzyme_27_Synonyms:
Glutathione S-transferase A3-3; GST class-alpha member 3

# Metabolic_Enzyme_27_Gene_Name:
GSTA3

# Metabolic_Enzyme_27_Protein_Sequence:
>Glutathione Stransferase A3
MAGKPKLHYFNGRGRMEPIRWLLAAAGVEFEEKFIGSAEDLGKLRNDGSLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYTEGMADLNEMILLLPLCRPEEKDAK
IALIKEKTKSRYFPAFEKVLQSHGQDYLVGNKLSRADISLVELLYYVEELDSSLISNFPL
LKALKTRISNLPTVKKFLQPGSPRKPPADAKALEEARKIFRF

# Metabolic_Enzyme_27_Number_of_Residues:
222

# Metabolic_Enzyme_27_Molecular_Weight:
25302

# Metabolic_Enzyme_27_Theoretical_pI:
9.69

# Metabolic_Enzyme_27_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  glutathione transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_27_General_Function:
Not Available

# Metabolic_Enzyme_27_Specific_Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)- pregnene-3,20-dione, precursors to testosterone and progesterone, respectively

# Metabolic_Enzyme_27_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_27_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_27_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Metabolic_Enzyme_27_Signals:
None

# Metabolic_Enzyme_27_Transmembrane_Regions:
None

# Metabolic_Enzyme_27_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_27_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_27_GenBank_ID_Protein:
951352

# Metabolic_Enzyme_27_SwissProt_ID:
GSTA3_HUMAN (Q16772)

# Metabolic_Enzyme_27_swissprot_Name:
Not Available

# Metabolic_Enzyme_27_Genecard_id:
GSTA3

# Metabolic_Enzyme_27_Geneatlas_id:
GSTA3

# Metabolic_Enzyme_27_hgnc_id:
HGNC:4628

# Metabolic_Enzyme_27_PDB_ID:
1TDI

# Metabolic_Enzyme_27_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_27_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_27_Gene_Sequence:
>688 bp
AAACCAGAAGACTGTTACCATGGCAGGGAAGCCCAAGCTTCACTACTTCAATGGACGGGG
CAGAATGGAGCCCATCCGGTGGCTCTTGGCTGCAGCTGGAGTAGAGTTTGAAGAGAAATT
TATAGGATCTGCAGAAGATTTGGGAAAGTTAAGAAATGATGGAAGTTTGATGTTCCAGCA
AGTGCCAATGGTTGAGATTGATGGGATGAAGTTGGTACAGACCAGAGCCATTCTCAACTA
CATTGCCAGCAAATACAACCTCTATGGGAAAGACATAAAGGAGAGAGCCCTAATTGATAT
GTATACAGAAGGTATGGCAGATTTGAATGAAATGATCCTTCTTCTGCCCTTATGTCCAGC
TGAGGAAAAAGATGCCAAGATTGCCTTGATCAAAGAGAAAATAAAAAGTCGCTATTTCCC
TGCCTTCGAAAAAGTGTTACAGAGCCATGGACAAGACTACCTTGTTGGCAACAAGCTGAG
CCGGGCTGACATTAGCCTGGTGGAACTTCTCTACTATGTGGAAGAGCTTGACTCCAGCCT
TATCTCCAACTTCCCTCTGCTGAAGGCCCTGAAAACCAGAATCAGCAACCTGCCCACGGT
GAAGAAGTTTCTACAGCCTGGCAGCCCAAGGAAGCCTCCCGCAGATGCAAAAGCTTTAGA
AGAAGCCAGAAAGATTTTCAGGTTTTAA

# Metabolic_Enzyme_27_GenBank_ID_Gene:
L13275

# Metabolic_Enzyme_27_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_27_Locus:
6p12.1

# Metabolic_Enzyme_27_SNPs:
Not Available

# Metabolic_Enzyme_27_General_References:
8307579; 11418619; 14574404; 9480897

# Metabolic_Enzyme_27_References:
Not Available

# Metabolic_Enzyme_28_ID:
6108

# Metabolic_Enzyme_28_Name:
Glutathione S-transferase A4

# Metabolic_Enzyme_28_Synonyms:
Glutathione S-transferase A4-4; GST class-alpha member 4

# Metabolic_Enzyme_28_Gene_Name:
GSTA4

# Metabolic_Enzyme_28_Protein_Sequence:
>Glutathione Stransferase A4
MAARPKLHYPNGRGRMESVRWVLAAAGVEFDEEFLETKEQLYKLQDGNHLLFQQVPMVEI
DGMKLVQTRSILHYIADKHNLFGKNLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKE
VVNMAQKAIIRYFPVFEKILRGHGQSFLVGNQLSLADVILLQTILALEEKIPNILSAFPF
LQEYTVKLSNIPTIKRFLEPGSKKKPPPDEIYVRTVYNIFRP

# Metabolic_Enzyme_28_Number_of_Residues:
222

# Metabolic_Enzyme_28_Molecular_Weight:
25705

# Metabolic_Enzyme_28_Theoretical_pI:
8.72

# Metabolic_Enzyme_28_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  glutathione transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_28_General_Function:
Not Available

# Metabolic_Enzyme_28_Specific_Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-HNE)

# Metabolic_Enzyme_28_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_28_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_28_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Metabolic_Enzyme_28_Signals:
None

# Metabolic_Enzyme_28_Transmembrane_Regions:
None

# Metabolic_Enzyme_28_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_28_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_28_GenBank_ID_Protein:
2597924

# Metabolic_Enzyme_28_SwissProt_ID:
GSTA4_HUMAN (O15217)

# Metabolic_Enzyme_28_swissprot_Name:
Not Available

# Metabolic_Enzyme_28_Genecard_id:
GSTA4

# Metabolic_Enzyme_28_Geneatlas_id:
GSTA4

# Metabolic_Enzyme_28_hgnc_id:
HGNC:4629

# Metabolic_Enzyme_28_PDB_ID:
1GUM

# Metabolic_Enzyme_28_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_28_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_28_Gene_Sequence:
>669 bp
ATGGCAGCAAGGCCCAAGCTCCACTATCCCAACGGAAGAGGCCGGATGGAGTCCGTGAGA
TGGGTTTTAGCTGCCGCCGGAGTCGAGTTTGATGAAGAATTTCTGGAAACAAAAGAACAG
TTGTACAAGTTGCAGGATGGTAACCACCTGCTGTTCCAACAAGTGCCCATGGTTGAAATT
GACGGGATGAAGTTGGTACAGACCCGAAGCATTCTCCACTACATAGCAGACAAGCACAAT
CTCTTTGGCAAGAACCTCAAGGAGAGAACCCTGATTGACATGTACGTGGAGGGGACACTG
GATCTGCTGGAACTGCTTATCATGCATCCTTTCTTAAAACCAGATGATCAGCAAAAGGAA
GTGGTTAACATGGCCCAGAAGGCTATAATTAGATACTTTCCTGTGTTTGAAAAGATTTTA
AGGGGTCACGGACAAAGCTTTCTTGTTGGTAATCAGCTGAGCCTTGCAGATGTGATTTTA
CTCCAAACCATTTTAGCTCTAGAAGAGAAAATTCCTAATATCCTGTCTGCATTTCCTTTC
CTCCAGGAATACACAGTGAAACTAAGTAATATCCCTACAATTAAGAGATTCCTTGAACCT
GGCAGCAAGAAGAAGCCTCCCCCTGATGAAATTTATGTGAGAACCGTCTACAACATCTTT
AGGCCATAA

# Metabolic_Enzyme_28_GenBank_ID_Gene:
Y13047

# Metabolic_Enzyme_28_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_28_Locus:
6p12.1

# Metabolic_Enzyme_28_SNPs:
Not Available

# Metabolic_Enzyme_28_General_References:
9461507; 9480897; 9587421; 9820822; 14574404; 10329152

# Metabolic_Enzyme_28_References:
Not Available

# Metabolic_Enzyme_29_ID:
6109

# Metabolic_Enzyme_29_Name:
Glutathione peroxidase 1

# Metabolic_Enzyme_29_Synonyms:
GSHPx-1; GPx-1; Cellular glutathione peroxidase

# Metabolic_Enzyme_29_Gene_Name:
GPX1

# Metabolic_Enzyme_29_Protein_Sequence:
>Glutathione peroxidase 1
MCAARLAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLCGTTVRDYTQMNEL
QRRLGPRGLVVLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAGA
HPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYSRR
FQTIDIEPDIEALLSQGPSCA

# Metabolic_Enzyme_29_Number_of_Residues:
201

# Metabolic_Enzyme_29_Molecular_Weight:
21899

# Metabolic_Enzyme_29_Theoretical_pI:
6.50

# Metabolic_Enzyme_29_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  glutathione peroxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_29_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_29_Specific_Function:
Protects the hemoglobin in erythrocytes from oxidative breakdown

# Metabolic_Enzyme_29_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_29_Reaction:
2 glutathione + H2O2 = glutathione disulfide + 2 H2O

# Metabolic_Enzyme_29_Pfam_Domain_Function:
PF00255:GSHPx

# Metabolic_Enzyme_29_Signals:
1-16

# Metabolic_Enzyme_29_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_29_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_29_EC_Link:
EC 1.11.1.9

# Metabolic_Enzyme_29_GenBank_ID_Protein:
577777

# Metabolic_Enzyme_29_SwissProt_ID:
GPX1_HUMAN (P07203)

# Metabolic_Enzyme_29_swissprot_Name:
Not Available

# Metabolic_Enzyme_29_Genecard_id:
GPX1

# Metabolic_Enzyme_29_Geneatlas_id:
GPX1

# Metabolic_Enzyme_29_hgnc_id:
HGNC:4553

# Metabolic_Enzyme_29_PDB_ID:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_29_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_29_Gene_Sequence:
>606 bp
ATGTGTGCTGCTCGGCTAGCGGCGGCGGCGGCCCAGTCGGTGTATGCCTTCTCGGCGCGC
CCGTTGGCCGGCGGGGAGCCTGTGAGCCTGGGCTCCCTGCGGGGCAAGGTACTACTTATC
GAGAATGTGGCGTCCCTCTGAGGCACCACGGTCCGGGACTACACCCAGATGAACGAGCTG
CAGCGGCGCCTCGGACCCCGGGGCCTGGTGGTGCTCGGCTTCCCGTGCAACCAGTTTGGG
CATCAGGAGAACGCCAAGAACGAAGAGATTCTGAATTCCCTCAAGTACGTCCGGCCTGGT
GGTGGGTTCGAGCCCAACTTCATGCTCTTCGAGAAGTGCGAGGTGAACGGTGCGGGGGCG
CACCCTCTCTTCGCCTTCCTGCGGGAGGCCCTGCCAGCTCCCAGCGACGACGCCACCGCG
CTTATGACCGACCCCAAGCTCATCACCTGGTCTCCGGTGTGTCGCAACGATGTTGCCTGG
AACTTTGAGAAGTTCCTGGTGGGCCCTGACGGTGTGCCCCTACGCAGGTACAGCCGCCGC
TTCCAGACCATTGACATCGAGCCTGACATCGAAGCCCTGCTGTCTCAAGGGCCCAGCTGT
GCCTAG

# Metabolic_Enzyme_29_GenBank_ID_Gene:
Y00433

# Metabolic_Enzyme_29_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_29_Locus:
3p21.3

# Metabolic_Enzyme_29_SNPs:
rs6446261; rs1050450; rs8179169; rs1050596; rs1050614; rs1803654; rs1050593; rs3210019; rs1800668; rs1050569; rs6790105; rs11720657; rs8179172; rs8179167; rs4991448; rs28362588; rs11549655; rs34170935; rs8179168; rs8179170; rs36043157; rs8179171; rs35810966; rs4955429; rs8179173; rs11711300; rs17080528; rs17650792; rs1804290; rs1804291; rs1987628; rs3191115; rs3204561; rs3448; rs3811698; rs3811699; rs8179164; rs8179165; rs8179166; rs8857; rs9609; rs974495

# Metabolic_Enzyme_29_General_References:
3658677; 3697069; 2955287; 2307470; 1556108; 10220143; 12496980

# Metabolic_Enzyme_29_References:
Not Available

# Metabolic_Enzyme_30_ID:
6110

# Metabolic_Enzyme_30_Name:
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial precursor

# Metabolic_Enzyme_30_Synonyms:
PHGPx; GPX-4

# Metabolic_Enzyme_30_Gene_Name:
GPX4

# Metabolic_Enzyme_30_Protein_Sequence:
>Phospholipid hydroperoxide glutathione peroxidase, mitochondrial precursor
MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR
GFVCIVTNVASQCGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA
AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRY
GPMEEPLVIEKDLPHYF

# Metabolic_Enzyme_30_Number_of_Residues:
197

# Metabolic_Enzyme_30_Molecular_Weight:
22128

# Metabolic_Enzyme_30_Theoretical_pI:
8.41

# Metabolic_Enzyme_30_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  glutathione peroxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_30_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_30_Specific_Function:
Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage

# Metabolic_Enzyme_30_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_30_Reaction:
2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H2O

# Metabolic_Enzyme_30_Pfam_Domain_Function:
PF00255:GSHPx

# Metabolic_Enzyme_30_Signals:
1-25

# Metabolic_Enzyme_30_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_30_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_30_EC_Link:
EC 1.11.1.12

# Metabolic_Enzyme_30_GenBank_ID_Protein:
825667

# Metabolic_Enzyme_30_SwissProt_ID:
GPX4_HUMAN (P36969)

# Metabolic_Enzyme_30_swissprot_Name:
Not Available

# Metabolic_Enzyme_30_Genecard_id:
GPX4

# Metabolic_Enzyme_30_Geneatlas_id:
GPX4

# Metabolic_Enzyme_30_hgnc_id:
HGNC:4556

# Metabolic_Enzyme_30_PDB_ID:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_30_Subcellular_Location:
Mitochondrion. Cytoplasm

# Metabolic_Enzyme_30_Gene_Sequence:
>594 bp
ATGAGCCTCGGCCGCCTTTGCCGCCTACTGAAGCCGGCGCTGCTCTGTGGGGCTCTGGCC
GCGCCTGGCCTGGCCGGGACCATGTGCGCGTCCCGGGACGACTGGCGCTGTGCGCGCTCC
ATGCACGAGTTTTCCGCCAAGGACATCGACGGGCACATGGTTAACCTGGACAAGTACCGG
GGCTTCGTGTGCATCGTCACCAACGTGGCCTCCCAGTGAGGCAAGACCGAAGTAAACTAC
ACTCAGCTCGTCGACCTGCACGCCCGATACGCTGAGTGTGGTTTGCGGATCCTGGCCTTC
CCGTGTAACCAGTTCGGGAAGCAGGAGCCAGGGAGTAACGAAGAGATCAAAGAGTTCGCC
GCGGGCTACAACGTCAAATTCGATATGTTCAGCAAGATCTGCGTGAACGGGGACGACGCC
CACCCGCTGTGGAAGTGGATGAAGATCCAACCCAAGGGCAAGGGCATCCTGGGAAATGCC
ATCAAGTGGAACTTCACCAAGTTCCTCATCGACAAGAACGGCTGCGTGGTGAAGCGCTAC
GGACCCATGGAGGAGCCCCTGGTGATAGAGAAGGACCTGCCCCACTATTTCTAG

# Metabolic_Enzyme_30_GenBank_ID_Gene:
X71973

# Metabolic_Enzyme_30_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_30_Locus:
19p13.3

# Metabolic_Enzyme_30_SNPs:
rs8178967; rs713041; rs4807542; rs1042863; rs8178966; rs34865773; rs2074450; rs8178977; rs8178968; rs4807543; rs8178976; rs8178975; rs8178970; rs8178974; rs8178973; rs757228; rs2074451; rs8178963; rs1808194; rs8178962; rs8178960; rs8178965; rs2075710; rs8178957; rs757230; rs757229; rs4588110; rs8103551; rs757231; rs35966855; rs35406680; rs8103169; rs8178961; rs8178978; rs8103188; rs8178958; rs3746166; rs8103283; rs35030170; rs34103661; rs3746165; rs34044728; rs34894724; rs8178959; rs35436265; rs35456941; rs34998479; rs11555179; rs4851; rs11555182; rs3177111; rs3203740; rs8178969; rs8178971; rs13343462; rs2072103; rs8178972; rs12978338; rs36207878; rs11407575; rs17526264; rs36208215; rs5826722; rs36207273; rs8178964; rs36207879; rs36207883; rs7508538; rs34283542; rs11309920; rs35919300; rs17554938; rs17554931; rs10416031; rs1043870; rs10439143; rs1046040; rs1046041; rs11084882; rs11668388; rs11881821; rs12459576; rs1609846; rs17526231; rs17551856; rs17554909; rs2072282; rs2072283; rs2074445; rs2074446; rs2074447; rs2074448; rs2074449; rs2074452; rs2075711; rs2159133; rs2302109; rs2302110; rs28612115; rs3746162; rs4239605; rs4806969; rs4806970; rs7249065

# Metabolic_Enzyme_30_General_References:
8039723; 9705830; 12606444

# Metabolic_Enzyme_30_References:
Not Available

# Metabolic_Enzyme_31_ID:
6111

# Metabolic_Enzyme_31_Name:
Glutathione peroxidase 3 precursor

# Metabolic_Enzyme_31_Synonyms:
GSHPx-3; GPx-3; Plasma glutathione peroxidase; GSHPx-P; Extracellular glutathione peroxidase; GPx-P

# Metabolic_Enzyme_31_Gene_Name:
GPX3

# Metabolic_Enzyme_31_Protein_Sequence:
>Glutathione peroxidase 3 precursor
MARLLQASCLLSLLLAGFVSQSRGQEKSKMDCHGGISGTIYEYGALTIDGEEYIPFKQYA
GKYVLFVNVASYCGLTGQYIELNALQEELAPFGLVILGFPCNQFGKQEPGENSEILPTLK
YVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDIR
WNFEKFLVGPDGIPIMRWHHRTTVSNVKMDILSYMRRQAALGVKRK

# Metabolic_Enzyme_31_Number_of_Residues:
226

# Metabolic_Enzyme_31_Molecular_Weight:
25506

# Metabolic_Enzyme_31_Theoretical_pI:
8.19

# Metabolic_Enzyme_31_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  glutathione peroxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_31_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_31_Specific_Function:
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione

# Metabolic_Enzyme_31_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_31_Reaction:
2 glutathione + H2O2 = glutathione disulfide + 2 H2O

# Metabolic_Enzyme_31_Pfam_Domain_Function:
PF00255:GSHPx

# Metabolic_Enzyme_31_Signals:
1-20

# Metabolic_Enzyme_31_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_31_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_31_EC_Link:
EC 1.11.1.9

# Metabolic_Enzyme_31_GenBank_ID_Protein:
2160390

# Metabolic_Enzyme_31_SwissProt_ID:
GPX3_HUMAN (P22352)

# Metabolic_Enzyme_31_swissprot_Name:
Not Available

# Metabolic_Enzyme_31_Genecard_id:
GPX3

# Metabolic_Enzyme_31_Geneatlas_id:
GPX3

# Metabolic_Enzyme_31_hgnc_id:
HGNC:4555

# Metabolic_Enzyme_31_PDB_ID:
Not Available

# Metabolic_Enzyme_31_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_31_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_31_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_31_Gene_Sequence:
>681 bp
ATGGCCCGGCTGCTGCAGGCGTCCTGCCTGCTTTCCCTGCTCCTGGCCGGCTTCGTCTCG
CAGAGCCGGGGACAAGAGAAGTCGAAGATGGACTGCCATGGTGGCATAAGTGGCACCATT
TACGAGTACGGAGCCCTCACCATTGATGGGGAGGAGTACATCCCCTTCAAGCAGTATGCT
GGCAAATACGTCCTCTTTGTCAACGTGGCCAGCTACTGAGGCCTGACGGGCCAGTACATT
GAACTGAATGCACTACAGGAAGAGCTTGCACCATTCGGTCTGGTCATTCTGGGCTTTCCC
TGCAACCAATTTGGAAAACAGGAACCAGGAGAGAACTCAGAGATCCTTCCTACCCTCAAG
TATGTCCGACCAGGTGGAGGCTTTGTCCCTAATTTCCAGCTCTTTGAGAAAGGGGATGTC
AATGGAGAGAAAGAGCAGAAATTCTACACTTTCCTAAAGAACTCCTGTCCTCCCACCTCG
GAGCTCCTGGGTACATCTGACCGCCTCTTCTGGGAACCCATGAAGGTTCACGACATCCGC
TGGAACTTTGAGAAGTTCCTGGTGGGGCCAGATGGTATACCCATCATGCGCTGGCACCAC
CGGACCACGGTCAGCAACGTCAAGATGGACATCCTGTCCTACATGAGGCGGCAGGCAGCC
CTGGGGGTCAAGAGGAAGTAA

# Metabolic_Enzyme_31_GenBank_ID_Gene:
D00632

# Metabolic_Enzyme_31_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_31_Locus:
5q23

# Metabolic_Enzyme_31_SNPs:
rs8177413; rs11548; rs2070593; rs4661; rs2230303; rs8177412; rs8177449; rs1064506; rs8177448; rs7722386; rs870407; rs3828599; rs8177426; rs4958434; rs4958872; rs869976; rs8177427; rs3792798; rs3792797; rs4958874; rs8177433; rs4958873; rs3792795; rs8177429; rs3805435; rs869975; rs3763012; rs8177447; rs8177435; rs6873202; rs3763011; rs870406; rs8177431; rs8177444; rs3792796; rs8177441; rs8177416; rs8177430; rs7721469; rs8177437; rs8177443; rs3792799; rs8177438; rs8177422; rs8177442; rs8177418; rs8177425; rs7704191; rs8177434; rs1946234; rs6888961; rs1946235; rs1946236; rs2042236; rs3763010; rs8177403; rs8177402; rs8177410; rs8177406; rs8177409; rs8177404; rs8177408; rs8177454; rs8177407; rs8177445; rs11544082; rs8177453; rs17111673; rs8177452; rs1059316; rs8177411; rs8177451; rs8177450; rs8177421; rs8177419; rs8177439; rs8177415; rs11959313; rs34764743; rs8177440; rs8177428; rs35012576; rs8177436; rs34933581; rs8177417; rs35977530; rs6889737; rs8177432; rs8177423; rs8177424; rs8177420; rs8177446; rs8177414; rs35278648; rs3834820; rs36207266; rs8177456; rs34605149; rs36206979; rs35156608; rs8177455; rs8177405; rs1053457; rs11747926; rs11953278; rs13357936; rs1803677; rs2042235; rs2233302; rs2233305; rs2233306; rs2233307; rs2233308; rs2233310; rs2233311; rs2233312; rs2277940; rs2287720; rs3763009; rs3763013; rs3763015; rs3924; rs707148; rs707149; rs707150; rs736775; rs8177834

# Metabolic_Enzyme_31_General_References:
2229017; 1339300; 8056346; 10970826; 1897960

# Metabolic_Enzyme_31_References:
Not Available

# Metabolic_Enzyme_32_ID:
6112

# Metabolic_Enzyme_32_Name:
Glutathione transferase omega-2

# Metabolic_Enzyme_32_Synonyms:
GSTO-2

# Metabolic_Enzyme_32_Gene_Name:
GSTO2

# Metabolic_Enzyme_32_Protein_Sequence:
>Glutathione transferase omega2
MSGDATRTLGKGSQPPGPVPEGLIRIYSMRFCPYSHRTRLVLKAKDIRHEVVNINLRNKP
EWYYTKHPFGHIPVLETSQCQLIYESVIACEYLDDAYPGRKLFPYDPYERARQKMLLELF
CKVPHLTKECLVALRCGRECTNLKAALRQEFSNLEEILEYQNTTFFGGTCISMIDYLLWP
WFERLDVYGILDCVSHTPALRLWISAMKWDPTVCALLMDKSIFQGFLNLYFQNNPNAFDF
GLC

# Metabolic_Enzyme_32_Number_of_Residues:
243

# Metabolic_Enzyme_32_Molecular_Weight:
28254

# Metabolic_Enzyme_32_Theoretical_pI:
7.62

# Metabolic_Enzyme_32_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  glutathione transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_32_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_32_Specific_Function:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_32_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_32_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_32_Pfam_Domain_Function:
PF02798:GST_N

# Metabolic_Enzyme_32_Signals:
None

# Metabolic_Enzyme_32_Transmembrane_Regions:
None

# Metabolic_Enzyme_32_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_32_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_32_GenBank_ID_Protein:
37777744

# Metabolic_Enzyme_32_SwissProt_ID:
GSTO2_HUMAN (Q9H4Y5)

# Metabolic_Enzyme_32_swissprot_Name:
Not Available

# Metabolic_Enzyme_32_Genecard_id:
GSTO2

# Metabolic_Enzyme_32_Geneatlas_id:
GSTO2

# Metabolic_Enzyme_32_hgnc_id:
HGNC:23064

# Metabolic_Enzyme_32_PDB_ID:
Not Available

# Metabolic_Enzyme_32_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_32_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_32_Subcellular_Location:
Not Available

# Metabolic_Enzyme_32_Gene_Sequence:
>732 bp
ATGTCTGGGGATGCGACCAGGACCCTGGGGAAAGGAAGCCAGCCCCCAGGGCCAGTCCCG
GAGGGGCTGATCCGCATCTACAGCATGAGGTTCTGCCCCTATTCTCACAGGACCCGCCTC
GTCCTCAAGGCCAAAGACATCAGACATGAAGTGGTCAACATTAACCTGAGAAACAAGCCT
GAATGGTACTATACAAAGCACCCTTTTGGCCACATTCCTGTCCTGGAGACCAGCCAATGT
CAACTGATCTATGAATCTGTTATTGCTTGTGAGTACCTGGATGATGCTTATCCAGGAAGG
AAGCTGTTTCCATATGACCCTTATGAACGAGCTCGCCAAAAGATGTTATTGGAGCTATTT
TGTAAGGTCCCACATTTGACCAAGGAGTGCCTGGTAGCGTTGAGATGTGGGAGAGAATGC
ACTAATCTGAAGGCAGCCCTGCGTCAGGAATTCAGCAACCTGGAAGAGATTCTTGAGTAT
CAGAACACCACCTTCTTTGGTGGAACCTGTATATCCATGATTGATTACCTCCTCTGGCCC
TGGTTTGAGCGGCTGGATGTGTATGGGATACTGGACTGTGTGAGCCACACGCCAGCCCTG
CGGCTCTGGATATCAGCCATGAAGTGGGACCCCACAGTCTGTGCTCTTCTCATGGATAAG
AGCATTTTCCAGGGCTTCTTGAATCTCTATTTTCAGAACAACCCTAATGCCTTTGACTTT
GGGCTGTGCTGA

# Metabolic_Enzyme_32_GenBank_ID_Gene:
AY350731

# Metabolic_Enzyme_32_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_32_Locus:
10q25.1

# Metabolic_Enzyme_32_SNPs:
rs156697; rs157078; rs3758572; rs568526; rs2297235; rs7914492; rs7089730; rs11191982; rs693873; rs7897376; rs10491045; rs11191984; rs11191986; rs11191985; rs12261808; rs7910156; rs17826034; rs12267156; rs12262176; rs637008; rs12262175; rs17116784; rs17116783; rs7898818; rs17116785; rs17116786; rs12773129; rs17116779; rs7913800; rs7913681; rs17116770; rs11191987; rs494431; rs11191980; rs11191983; rs589007; rs12247206; rs157080; rs276210; rs276203; rs157076; rs987247; rs276204; rs157081; rs156699; rs157077; rs7915805; rs1865926; rs7070750; rs12258393; rs7906069; rs17116838; rs11191990; rs10437481; rs17116834; rs12570383; rs12245345; rs17116822; rs7896341; rs17116796; rs7078651; rs703346; rs11191988; rs7087614; rs11191991; rs17116798; rs11191992; rs7073890; rs3818647; rs10437455; rs6584592; rs7099030; rs11812790; rs12241680; rs7079338; rs4142057; rs17116831; rs7905462; rs12264024; rs7086817; rs11191989; rs12783850; rs12253098; rs10509769; rs12264646; rs641071; rs17116848; rs12264844; rs34400162; rs35204326; rs12251225; rs12784102; rs10525907; rs35937878; rs635892; rs814215; rs35416185; rs7913562; rs11449636; rs3832691; rs34435414; rs11279710; rs34265126; rs34739624; rs10590204; rs7913564; rs35351925; rs35037627; rs11818492; rs35265789; rs35233251; rs12265060; rs2902641; rs276200; rs7073265; rs36032394; rs188034; rs34478015; rs7899587; rs34353706; rs157079; rs34771674; rs34048707; rs34199276; rs11347549; rs7899342; rs34334361; rs12412065; rs35413472; rs35715009; rs35690921; rs7923376; rs35481786; rs12219168; rs34090030; rs276201; rs35924701; rs34139255; rs1436924; rs2282095; rs276202; rs34866572; rs5787514; rs35528873; rs12254869; rs35923443; rs10715615; rs156698; rs34359560; rs1595259; rs11321519; rs1621106; rs34493703; rs1750072; rs11460683; rs34082335; rs12358739; rs34655679; rs12219470; rs1045505; rs11191979; rs11191993; rs11191994; rs11191995; rs11191996; rs11191998; rs11191999; rs11192000; rs11192001; rs11192002; rs1147611; rs11509436; rs11509438; rs11509439; rs12241913; rs12244332; rs12258262; rs12259337; rs12263834; rs12264196; rs15032; rs17116741; rs17116751; rs17116753; rs17116754; rs17116755; rs17116758; rs17883344; rs17884170; rs1804834; rs2282092; rs2282093; rs2282094; rs2282326; rs276207; rs3211015; rs35923331; rs3740466; rs4925; rs6584593; rs7067832; rs7067878; rs7077259; rs7077635; rs7077729; rs7077787; rs7077797; rs7083244; rs7085427; rs7085593; rs7085725; rs7096068; rs7099492; rs7101149; rs7589; rs7906559; rs7906892; rs7906957; rs914066

# Metabolic_Enzyme_32_General_References:
12618591

# Metabolic_Enzyme_32_References:
Not Available

# Metabolic_Enzyme_33_ID:
6113

# Metabolic_Enzyme_33_Name:
Glutathione S-transferase theta-1

# Metabolic_Enzyme_33_Synonyms:
GST class-theta-1; Glutathione transferase T1-1

# Metabolic_Enzyme_33_Gene_Name:
GSTT1

# Metabolic_Enzyme_33_Protein_Sequence:
>Glutathione Stransferase theta1
MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKGQHLSDAFAQVNPLKKVPALKDG
DFTLTESVAILLYLTRKYKVPDYWYPQDLQARARVDEYLAWQHTTLRRSCLRALWHKVMF
PVFLGEPVSPQTLAATLAELDVTLQLLEDKFLQNKAFLTGPHISLADLVAITELMHPVGA
GCQVFEGRPKLATWRQRVEAAVGEDLFQEAHEVILKAKDFPPADPTIKQKLMPWVLAMIR


# Metabolic_Enzyme_33_Number_of_Residues:
240

# Metabolic_Enzyme_33_Molecular_Weight:
27335

# Metabolic_Enzyme_33_Theoretical_pI:
7.60

# Metabolic_Enzyme_33_GO_Classification:
Not Available

# Metabolic_Enzyme_33_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_33_Specific_Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide

# Metabolic_Enzyme_33_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_33_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_33_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Metabolic_Enzyme_33_Signals:
1-16

# Metabolic_Enzyme_33_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_33_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_33_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_33_GenBank_ID_Protein:
510905

# Metabolic_Enzyme_33_SwissProt_ID:
GSTT1_HUMAN (P30711)

# Metabolic_Enzyme_33_swissprot_Name:
Not Available

# Metabolic_Enzyme_33_Genecard_id:
GSTT1

# Metabolic_Enzyme_33_Geneatlas_id:
GSTT1

# Metabolic_Enzyme_33_hgnc_id:
HGNC:4641

# Metabolic_Enzyme_33_PDB_ID:
Not Available

# Metabolic_Enzyme_33_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_33_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_33_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_33_Gene_Sequence:
>723 bp
ATGGGTCTGGAGCTCTACCTGGACCTGCTGTCCCAGCCCTGCCGCGCTGTTTACATCTTT
GCCAAGAAGAACGACATTCCCTTCGAGCTGCGCATCGTGGATCTGATTAAAGGTCAGCAC
TTAAGCGATGCCTTTGCCCAGGTGAACCCCCTCAAGAAGGTGCCGGCCTTGAAGGACGGG
GACTTCACCTTGACGGAGAGTGTGGCCATCCTGCTCTACCTGACGCGCAAATATAAGGTC
CCTGACTACTGGTACCCTCAGGACCTGCAGGCCCGTGCCCGTGTGGATGAGTACCTGGCA
TGGCAGCACACGACTCTGCGGAGAAGCTGCCTCCGGGCCTTGTGGCATAAGGTGATGTTC
CCTGTGTTCCTGGGTGGGCCAGTATCTCCCCAGACACTGGCAGCCACCCTGGCAGAGTTG
GATGTGACCCTGCAGTTGCTCGAGGACAAGTTCCTCCAGAACAAGGCCTTCCTTACTGGT
CCTCACATCTCCTTAGCTGACCTCGTAGCCATCACGGAGCTGATGCATCCCGTGGGTGCT
GGCTGCCAAGTCTTCGAAGGCCGACCCAAGCTGGCCACATGGCGGCAGCGCGTGGAGGCA
GCAGTGGGGGAGGACCTCTTCCAGGAGGCCCATGAGGTCATTCTGAAGGCCAAGGACTTC
CCACCTGCAGACCCCACCATAAAGCAGAAGCTGATGCCCTGGGTGCTGGCCATGATCCGG
TGA

# Metabolic_Enzyme_33_GenBank_ID_Gene:
X79389

# Metabolic_Enzyme_33_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_33_Locus:
22q11.23

# Metabolic_Enzyme_33_SNPs:
rs2266637; rs2266633; rs2234953; rs2266636; rs4630; rs140313; rs6004034; rs8140585; rs2844008; rs2234734; rs2234735; rs6519497; rs2844009; rs2739345; rs6004035; rs5996657; rs11550605; rs2266635; rs11550606; rs17856199; rs17850155; rs1130990; rs140308; rs10549055; rs36074818; rs34861338; rs140309; rs3804072; rs140310; rs140311; rs5760163; rs140312; rs34601995; rs34380312; rs34077507; rs140314; rs13055680; rs36211400; rs2739346; rs36211744; rs35936148; rs34074938; rs2844007; rs4147582; rs9624383; rs5760168

# Metabolic_Enzyme_33_General_References:
8198545; 9434735; 10975610; 10591208; 1848757; 8761485

# Metabolic_Enzyme_33_References:
Not Available

# Metabolic_Enzyme_34_ID:
6114

# Metabolic_Enzyme_34_Name:
Glutathione peroxidase 2

# Metabolic_Enzyme_34_Synonyms:
GSHPx-2; GPx-2; Glutathione peroxidase-gastrointestinal; GSHPx-GI; Glutathione peroxidase- related protein 2; Gastrointestinal glutathione peroxidase; GPRP

# Metabolic_Enzyme_34_Gene_Name:
GPX2

# Metabolic_Enzyme_34_Protein_Sequence:
>Glutathione peroxidase 2
MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLCGTTTRDFTQLNELQCRFPRR
LVVLGFPCNQFGHQENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLK
DKLPYPYDDPFSLMTDPKLIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEP
DIKRLLKVAI

# Metabolic_Enzyme_34_Number_of_Residues:
190

# Metabolic_Enzyme_34_Molecular_Weight:
21907

# Metabolic_Enzyme_34_Theoretical_pI:
7.84

# Metabolic_Enzyme_34_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  glutathione peroxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_34_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_34_Specific_Function:
Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors

# Metabolic_Enzyme_34_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_34_Reaction:
2 glutathione + H2O2 = glutathione disulfide + 2 H2O

# Metabolic_Enzyme_34_Pfam_Domain_Function:
PF00255:GSHPx

# Metabolic_Enzyme_34_Signals:
None

# Metabolic_Enzyme_34_Transmembrane_Regions:
None

# Metabolic_Enzyme_34_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_34_EC_Link:
EC 1.11.1.9

# Metabolic_Enzyme_34_GenBank_ID_Protein:
4902773

# Metabolic_Enzyme_34_SwissProt_ID:
GPX2_HUMAN (P18283)

# Metabolic_Enzyme_34_swissprot_Name:
Not Available

# Metabolic_Enzyme_34_Genecard_id:
GPX2

# Metabolic_Enzyme_34_Geneatlas_id:
GPX2

# Metabolic_Enzyme_34_hgnc_id:
HGNC:4554

# Metabolic_Enzyme_34_PDB_ID:
Not Available

# Metabolic_Enzyme_34_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_34_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_34_Subcellular_Location:
Cytoplasm. Note=Mainly cytoplasmic

# Metabolic_Enzyme_34_Gene_Sequence:
>573 bp
ATGGCTTTCATTGCCAAGTCCTTCTATGACCTCAGTGCCATCAGCCTGGATGGGGAGAAG
GTAGATTTCAATACGTTCCGGGGCAGGGCCGTGCTGATTGAGAATGTGCGTTCGCTCTGA
GGCACAACCACCCGGGACTTCACCCAGCTCAACGAGCTGCAATGCCGCTTTCCCAGGCGC
CTGGTGGTCCTTGGCTTCCCTTGCAACCAATTTGGACATCAGGAGAACAGTCAGAATGAG
GAGATCCTGAACAGTCTCAAGTATGTCCGTCCTGGGGGTGGATACCAGCCCACCTTCACC
CTTGTCCAAAAATGTGAGGTGAATGGGCAGAACGAGCATCCTGTCTTCGCCTACCTGAAG
GACAAGCTCCCCTACCCTTATGATGACCCATTTTCCCTCATGACCGATCCCAAGCTCATC
ATTTGGAGCCCTGTGCGCCGCTCAGATGTGGCCTGGAACTTTGAGAAGTTCCTCATAGGG
CCGGAGGGAGAGCCCTTCCGACGCTACAGCCGCACCTTCCCAACCATCAACATTGAGCCT
GACATCAAGCGCCTCCTTAAAGTTGCCATATAG

# Metabolic_Enzyme_34_GenBank_ID_Gene:
X53463

# Metabolic_Enzyme_34_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_34_Locus:
14q24.1

# Metabolic_Enzyme_34_SNPs:
rs17880492; rs10145845; rs2737844; rs2071566; rs6413431; rs2412065; rs1800669; rs17880758; rs17883875; rs4902346; rs2737848; rs17880303; rs17880632; rs2737847; rs17882875; rs4902345; rs10133290; rs2296327; rs11623705; rs3825644; rs17880939; rs10133054; rs17883620; rs17883358; rs17884341; rs17880850; rs12172810; rs4902347; rs17880145; rs34428768; rs35838246; rs17093568; rs10132858; rs35429193; rs34067020; rs17884348; rs17881498; rs17880380; rs34061076; rs3831077; rs35019707; rs17881260; rs17102360; rs17883073; rs17881652; rs17885748; rs3182293; rs2737849; rs17884574; rs17881052; rs17881414; rs2737846; rs17883359; rs17884124; rs2737845; rs34528750; rs17883153; rs17880209; rs17883123; rs36065255; rs17883333; rs36206353; rs36206681; rs17881876; rs2763890; rs36206977; rs17886872; rs2737851; rs2737850; rs36206674; rs36206974; rs2737843; rs17883566; rs17880421; rs17881659; rs17881154; rs17886370; rs2737852; rs11628603; rs17886560; rs12895624; rs2763889; rs36206677; rs4899154; rs10121; rs10137070; rs10147758; rs10149617; rs1044580; rs1045712; rs1064108; rs11540871; rs17752452; rs1886506; rs1951992; rs1951993; rs2277501; rs2277502; rs2296325; rs2296326; rs3087955; rs35179634; rs35263628; rs3742599; rs3759682; rs3825643; rs4902342; rs4902343; rs6745; rs7157667; rs8006570; rs9323457

# Metabolic_Enzyme_34_General_References:
2388849; 8428933; 10806356

# Metabolic_Enzyme_34_References:
Not Available

# Metabolic_Enzyme_35_ID:
6004

# Metabolic_Enzyme_35_Name:
Gamma-glutamyltransferase 5 precursor

# Metabolic_Enzyme_35_Synonyms:
Gamma- glutamyltranspeptidase 5; Gamma-glutamyltransferase-like activity 1; GGT-rel[Contains: Gamma-glutamyltransferase 5 heavy chain; Gamma- glutamyltransferase 5 light chain]

# Metabolic_Enzyme_35_Gene_Name:
GGTLA1

# Metabolic_Enzyme_35_Protein_Sequence:
>Gammaglutamyltransferase 5 precursor
MARGYGATVSLVLLGLGLALAVIVLAVVLSRHQAPCGPQAFAHAAVAADSKVCSDIGRAI
LQQQGSPVDA
TIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPASHAP
SLLDQCAQALPLGTGAQWIGV
PGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAP
VLSRFLHNSILRPSLQASTLRQLFFNGTEPLR
PQDPLPWPALATTLETVATEGVEVFYT
GRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTL
YSPPPPAGGAILSFIL
NVLRGFNFSTESMARPEGRVNVYHHLVETLKFAKGQRWRLGDPRSHPKLQNASR
DLLGE
TLAQLIRQQIDGRGDHQLSHYSLAEAWGHGTGTSHVSVLGEDGSAVAATSTINTPFGAMV
YSPRT
GIILNNELLDLCERCPRGSGTTPSPVSGDRVGGAPGRCWPPVPGERSPSSMVPS
ILINKAQGSKLVIGGA
GGELIISAVAQAIMSKLWLGFDLRAAIAAPILHVNSKGCVEYE
PNFSQEVQRGLQDRGQNQTQRPFFLNV
VQAVSQEGACVYAVSDLRKSGEAAGY

# Metabolic_Enzyme_35_Number_of_Residues:
586

# Metabolic_Enzyme_35_Molecular_Weight:
62262

# Metabolic_Enzyme_35_Theoretical_pI:
7.59

# Metabolic_Enzyme_35_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring amino-acyl groups
Function:  gamma-glutamyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_35_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_35_Specific_Function:
Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4)

# Metabolic_Enzyme_35_Pathway:
map00430  Taurine and hypotaurine metabolism;
 map00450  Selenoamino acid metabolism;
 map00460  Cyanoamino acid metabolism;
 map00480  Glutathione metabolism;
 map00590  Prostaglandin and leukotriene metabolism

# Metabolic_Enzyme_35_Reaction:
(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid

# Metabolic_Enzyme_35_Pfam_Domain_Function:
PF01019:G_glu_transpept

# Metabolic_Enzyme_35_Signals:
1-26

# Metabolic_Enzyme_35_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_35_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_35_EC_Link:
EC 2.3.2.2

# Metabolic_Enzyme_35_GenBank_ID_Protein:
183142

# Metabolic_Enzyme_35_SwissProt_ID:
GGT5_HUMAN (P36269)

# Metabolic_Enzyme_35_swissprot_Name:
Not Available

# Metabolic_Enzyme_35_Genecard_id:
GGTLA1

# Metabolic_Enzyme_35_Geneatlas_id:
GGTLA1

# Metabolic_Enzyme_35_hgnc_id:
HGNC:4260

# Metabolic_Enzyme_35_PDB_ID:
Not Available

# Metabolic_Enzyme_35_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_35_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_35_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_35_Gene_Sequence:
>1761 bp

ATGGCCCGGGGCTACGGGGCCACGGTCAGCCTAGTCCTGCTGGGTCTGGGGCTGGCGCT
GGCTGTCATTG
TGCTGGCTGTGGTCCTCTCTCGACACCAGGCCCCATGTGGCCCCCAGG
CCTTTGCCCACGCTGCTGTTGC
CGCCGACTCCAAGGTCTGCTCGGATATTGGACGAGCC
ATCCTCCAGCAGCAGGGCTCACCCGTGGATGCC
ACCATCGCGGCTCTGGTCTGCACCAG
CGTCGTCAACCCTCAGAGCATGGGCCTGGGCGGAGGGGTCATCT
TCACCATCTACAATG
TGACAACAGGGAAGGTGGAGGTCATCAATGCCCGGGAGACGGTGCCGGCCAGCCA
CGCC
CCGAGCCTGCTGGACCAGTGTGCACAGGCTCTGCCACTGGGCACAGGGGCCCAGTGGATC
GGGGTG
CCCGGGGAGCTCCGTGGCTATGCCGAGGCCCACCGCCGCCATGGCCGCCTGCC
CTGGGCGCAGCTGTTCC
AGCCCACCATCGCGCTGCTCCGAGGGGGGCATGTGGTGGCCC
CTGTCCTCAGCCGTTTCCTGCACAACAG
CATCCTGCGGCCTTCCTTGCAGGCGTCAACC
CTGCGCCAGCTCTTCTTCAACGGGACAGAACCCCTGAGG
CCTCAGGACCCACTCCCATG
GCCTGCACTGGCCACCACCCTGGAGACCGTGGCCACAGAGGGCGTGGAGG
TCTTCTACA
CGGGGAGGCTGGGCCAGATGCTGGTGGAGGACATTGCCAAGGAAGGGAGCCAGCTGACGC
T
GCAGGACCTGGCCAAGTTCCAGCCCGAGGTGGTGGATGCCCTGGAGGTGCCCCTGGGG
GACTATACCCTG
TACTCACCACCGCCGCCTGCAGGGGGTGCCATTCTCAGCTTTATCCT
CAACGTGCTAAGAGGGTTCAACT
TCTCAACAGAGTCTATGGCCAGGCCTGAAGGGAGGG
TGAACGTGTACCACCACCTTGTAGAGACGCTCAA
GTTTGCCAGGGGGCAGAGGTGGAGG
CTGGGGGACCCTCGAAGCCACCCGAAGCTCCAGAATGCCTCCCGG
GACCTGCTGGGGGA
GACCCTGGCCCAGCTCATCCGCCAACAGATCGATGGCCGGGGGGACCACCAGCTCA
GCC
ACTACAGCTTGGCCGAGGCCTGGGGCCACGGGACAGGCACGTCCCATGTGTCTGTGCTGG
GGGAGGA
TGGCAGCGCCGTGGCTGCCACCAGCACCATCAACACACCCTTTGGAGCGATG
GTGTATTCACCACGGACA
GGCATCATCCTCAACAACGAGCTCCTGGACTTATGCGAGCG
ATGCCCCTGGGGTTCCGGCACCACCCCCT
CACCTGTGAGTGGAGACAGGGTGGGTGGAG
CTCCCGGAAGGTGCTGGCCCCCAGTTCCAGGCGAGCGTTC
CCCATCCTCCATGGTGCCC
TCCATCTTGATCAACAAAGCCCAGGGGTCGAAGCTAGTGATTGGCGGGGCT
GGCGGGGA
GCTCATCATCTCTGCTGTGGCCCAGGCCATCATGAGCAAGCTGTGGCTTGGCTTTGACCT
GA
GAGCGGCCATTGCAGCCCCCATCCTGCATGTCAACAGCAAGGGCTGTGTGGAGTACG
AGCCCAACTTCAG
CCAGGAGGTGCAGAGGGGACTCCAAGACCGTGGCCAGAACCAGACC
CAGAGGCCCTTCTTCCTGAACGTG
GTCCAGGCTGTGTCCCAGGAGGGGGCCTGTGTGTA
CGCCGTCTCGGACCTGAGGAAGAGTGGGGAGGCCG
CAGGCTACTAA

# Metabolic_Enzyme_35_GenBank_ID_Gene:
M64099

# Metabolic_Enzyme_35_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_35_Locus:
22q11.23

# Metabolic_Enzyme_35_SNPs:
rs7288201; rs2275984; rs762276; rs4443101; rs8140505; rs2267073; rs8135709; rs2267074; rs5996675; rs5996676; rs8142702; rs4822473; rs8140559; rs5751820; rs2275985; rs5751822; rs5760273; rs9612567; rs7286769; rs12627971; rs8141279; rs2330738; rs9608253; rs5760270; rs9608254; rs6004109; rs6004104; rs8135864; rs7288670; rs7286276; rs9608250; rs5760271; rs2877206; rs5751821; rs518219; rs9612575; rs2275983; rs7286275; rs6004103; rs9608256; rs915597; rs9608255; rs738810; rs2078191; rs11090315; rs13053599; rs12166260; rs11913528; rs5751819; rs5760274; rs6004105; rs8142028; rs34787869; rs3171733; rs28470453; rs35519802; rs4049960; rs8141921; rs2186375; rs11446984; rs11912938; rs35151649; rs9608251; rs34162764; rs9612568; rs34456415; rs36080744; rs9608261; rs507572; rs12158478; rs8141917; rs7288678; rs9612571; rs12169644; rs4049956; rs9624432; rs8140966; rs8140009; rs12170724; rs35658121; rs12165595; rs13054993; rs34139406; rs36078496; rs5760272; rs28558344; rs2196265; rs7286843; rs34408756; rs9612569; rs9608257; rs6004107; rs8140350; rs7289730; rs28765434; rs28581334; rs34254169; rs915596; rs9608263; rs9608258; rs35424805; rs9624434; rs9624435; rs4049959; rs8142438; rs5760267; rs34213657; rs8137278; rs34286685; rs35687403; rs507543; rs28433519; rs9612570; rs9608252; rs6004108; rs5760268; rs34690574; rs35456290; rs35720801; rs34544519; rs507578; rs35482725; rs8141879; rs13056182; rs35048159; rs35924097; rs34183480; rs35060391; rs4049958; rs35676668; rs9612572; rs5760269; rs35673322; rs8137410; rs9608260; rs7285631; rs13054426; rs2154608; rs35357003; rs34686376; rs7291369; rs2186373; rs9680720; rs35387722; rs9608262; rs10428035; rs12158941; rs13054853; rs2186374; rs3966270; rs11913894; rs7290701; rs10427555; rs34505104; rs7291063; rs8142646; rs12169182; rs4049957; rs12160538; rs34593708; rs8136200; rs13054966; rs9608259; rs507542; rs4049961; rs5760266; rs4408818; rs28562380; rs9624430; rs8137281; rs35334731; rs204713; rs12159878; rs5760265; rs7289030; rs34949320; rs34303680; rs34756406; rs28503851; rs13055027; rs13057276; rs12166267; rs9608249; rs35351787; rs34288539; rs28447258; rs28480057; rs28635067; rs34513858; rs35229275; rs583199; rs5996674; rs6004094; rs6004099; rs743359; rs743360; rs9612564

# Metabolic_Enzyme_35_General_References:
1676842; 10591208

# Metabolic_Enzyme_35_References:
Not Available

# Metabolic_Enzyme_36_ID:
6115

# Metabolic_Enzyme_36_Name:
Glutathione S-transferase P

# Metabolic_Enzyme_36_Synonyms:
GST class-pi; GSTP1-1

# Metabolic_Enzyme_36_Gene_Name:
GSTP1

# Metabolic_Enzyme_36_Protein_Sequence:
>Glutathione Stransferase 
PMPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDG
DLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDY
VKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSA
YVGRLSARPKLKAFLASPEYVNLPINGNGKQ

# Metabolic_Enzyme_36_Number_of_Residues:
210

# Metabolic_Enzyme_36_Molecular_Weight:
23356

# Metabolic_Enzyme_36_Theoretical_pI:
5.30

# Metabolic_Enzyme_36_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  glutathione transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_36_General_Function:
Not Available

# Metabolic_Enzyme_36_Specific_Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

# Metabolic_Enzyme_36_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_36_Reaction:
RX + glutathione = HX + R-S-glutathione

# Metabolic_Enzyme_36_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Metabolic_Enzyme_36_Signals:
1-17

# Metabolic_Enzyme_36_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_36_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_36_EC_Link:
EC 2.5.1.18

# Metabolic_Enzyme_36_GenBank_ID_Protein:
31946

# Metabolic_Enzyme_36_SwissProt_ID:
GSTP1_HUMAN (P09211)

# Metabolic_Enzyme_36_swissprot_Name:
Not Available

# Metabolic_Enzyme_36_Genecard_id:
GSTP1

# Metabolic_Enzyme_36_Geneatlas_id:
GSTP1

# Metabolic_Enzyme_36_hgnc_id:
HGNC:4638

# Metabolic_Enzyme_36_PDB_ID:
13GS

# Metabolic_Enzyme_36_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_36_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_36_Subcellular_Location:
Not Available

# Metabolic_Enzyme_36_Gene_Sequence:
>633 bp
ATGCCGCCCTACACCGTGGTCTATTTCCCAGTTCGAGGCCGCTGCGCGGCCCTGCGCATG
CTGCTGGCAGATCAGGGCCAGAGCTGGAAGGAGGAGGTGGTGACCGTGGAGACGTGGCAG
GAGGGCTCACTCAAAGCCTCCTGCCTATACGGGCAGCTCCCCAAGTTCCAGGACGGAGAC
CTCACCCTGTACCAGTCCAATACCATCCTGCGTCACCTGGGCCGCACCCTTGGGCTCTAT
GGGAAGGACCAGCAGGAGGCAGCCCTGGTGGACATGGTGAATGACGGCGTGGAGGACCTC
CGCTGCAAATACATCTCCCTCATCTACACCAACTATGAGGCGGGCAAGGATGACTATGTG
AAGGCACTGCCCGGGCAACTGAAGCCTTTTGAGACCCTGCTGTCCCAGAACCAGGGAGGC
AAGACCTTCATTGTGGGAGACCAGATCTCCTTCGCTGACTACAACCTGCTGGACTTGCTG
CTGATCCATGAGGTCCTAGCCCCTGGCTGCCTGGATGCGTTCCCCCTGCTCTCAGCATAT
GTGGGGCGCCTCAGCGCCCGGCCCAAGCTCAAGGCCTTCCTGGCCTCCCCTGAGTACGTG
AACCTCCCCATCAATGGCAACGGGAAACAGTGA

# Metabolic_Enzyme_36_GenBank_ID_Gene:
X06547

# Metabolic_Enzyme_36_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_36_Locus:
11q13

# Metabolic_Enzyme_36_SNPs:
rs4986948; rs4986949; rs1138272; rs41462048; rs1695; rs8191448; rs4891; rs8191439; rs6413486; rs749174; rs1871041; rs1079719; rs743679; rs762803; rs1871042; rs2370143; rs8191446; rs4147581; rs8191441; rs675554; rs8191443; rs8191445; rs8191449; rs6591256; rs947895; rs6591255; rs8191431; rs8191438; rs17593068; rs643318; rs7949587; rs7949394; rs8191430; rs694746; rs643317; rs8191435; rs11553893; rs11553892; rs8191444; rs12796085; rs11553890; rs5031031; rs5792420; rs3082938; rs34712235; rs11282759; rs3082937; rs35716946; rs8191450; rs3891249; rs35175720; rs8191447; rs35701803; rs8191451; rs8191440; rs10695152; rs36211088; rs11311623; rs8191452; rs8191436; rs36211089; rs10545734; rs35325498; rs36211087; rs8191432; rs35867059; rs11311624; rs35411165; rs11409267; rs11311625; rs35318457; rs10695151; rs1065670; rs11227844; rs12278098; rs12284337; rs12574108; rs2035186; rs2169650; rs596603; rs612020; rs614080; rs625978; rs641544; rs656652; rs656798; rs6591251; rs6591252; rs6591258; rs7927381; rs7927657; rs7940813; rs7941395; rs7941648; rs7945035; rs8191453

# Metabolic_Enzyme_36_General_References:
3664469; 3196325; 2542132; 2466554; 9092542; 3979555; 3864155; 3395118; 12665801; 9150948; 2327795; 1522586; 9012673; 9245401; 9398518; 9351803; 10441116; 9485454; 8433974

# Metabolic_Enzyme_36_References:
Not Available

# Metabolic_Enzyme_37_ID:
6223

# Metabolic_Enzyme_37_Name:
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

# Metabolic_Enzyme_37_Synonyms:
Beta-1,3-glucuronyltransferase 1; Glucuronosyltransferase-P; GlcAT-P; UDP-GlcUA:glycoprotein beta- 1,3-glucuronyltransferase; GlcUAT-P

# Metabolic_Enzyme_37_Gene_Name:
B3GAT1

# Metabolic_Enzyme_37_Protein_Sequence:
>Galactosylgalactosylxylosylprotein 3betaglucuronosyltransferase 1
MPKRRDILAIVLIVLPWTLLITVWHQSTLAPLLAVHKDEGSDPRRETPPGADPREYCTSD
RDIVEVVRTEYVYTRPPPWSDTLPTIHVVTPTYSRPVQKAELTRMANTLLHVPNLHWLVV
EDAPRRTPLTARLLRDTGLNYTHLHVETPRNYKLRGDARDPRIPRGTMQRNLALRWLRET
FPRNSSQPGVVYFADDDNTYSLELFEEMRSTRRVSVWPVAFVGGLRYEAPRVNGAGKVVR
WKTVFDPHRPFAIDMAGFAVNLRLILQRSQAYFKLRGVKGGYQESSLLRELVTLNDLEPK
AANCTKILVWHTRTEKPVLVNEGKKGFTDPSVEI

# Metabolic_Enzyme_37_Number_of_Residues:
334

# Metabolic_Enzyme_37_Molecular_Weight:
38356

# Metabolic_Enzyme_37_Theoretical_pI:
10.13

# Metabolic_Enzyme_37_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  UDP-glycosyltransferase activity
Function:  glucuronosyltransferase activity
Function:  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_37_General_Function:
Not Available

# Metabolic_Enzyme_37_Specific_Function:
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo- orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity:stearoyl- sphingomyelin was the most effective, followed by palmitoyl- sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group

# Metabolic_Enzyme_37_Pathway:
map00532  Chondroitin / Heparan sulfate biosynthesis

# Metabolic_Enzyme_37_Reaction:
UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein

# Metabolic_Enzyme_37_Pfam_Domain_Function:
PF03360:Glyco_transf_43

# Metabolic_Enzyme_37_Signals:
1-29

# Metabolic_Enzyme_37_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_37_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_37_EC_Link:
EC 2.4.1.135

# Metabolic_Enzyme_37_GenBank_ID_Protein:
8051678

# Metabolic_Enzyme_37_SwissProt_ID:
B3GA1_HUMAN (Q9P2W7)

# Metabolic_Enzyme_37_swissprot_Name:
Not Available

# Metabolic_Enzyme_37_Genecard_id:
B3GAT1

# Metabolic_Enzyme_37_Geneatlas_id:
B3GAT1

# Metabolic_Enzyme_37_hgnc_id:
HGNC:921

# Metabolic_Enzyme_37_PDB_ID:
Not Available

# Metabolic_Enzyme_37_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_37_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_37_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_37_Gene_Sequence:
>1005 bp
ATGCCGAAGAGACGGGACATCCTAGCGATCGTCCTCATCGTGCTGCCCTGGACTCTGCTC
ATCACTGTCTGGCACCAGAGCACCCTCGCACCCCTGCTCGCGGTACATAAGGATGAGGGC
AGTGACCCCCGACGCGAAACGCCGCCCGGCGCCGACCCCAGGGAGTACTGCACGTCTGAC
CGCGACATCGTGGAGGTGGTGCGCACCGAGTACGTGTACACGCGGCCCCCGCCATGGTCC
GACACGCTGCCCACCATCCACGTGGTGACGCCCACCTACAGCCGCCCGGTGCAGAAGGCC
GAGCTGACGCGCATGGCCAACACGCTGCTGCACGTGCCCAACCTCCACTGGCTGGTGGTG
GAGGATGCGCCGCGCCGGACGCCGCTGACCGCGCGCCTGCTGCGCGACACCGGCCTCAAC
TACACGCACCTGCACGTGGAGACGCCCCGCAACTACAAGCTGCGCGGAGACGCCCGCGAC
CCACGCATCCCGCGGGGCACCATGCAGCGCAACCTGGCCCTGCGCTGGCTGCGCGAGACC
TTCCCGCGCAACTCCAGCCAGCCTGGCGTGGTCTACTTCGCCGACGACGACAACACCTAC
AGCCTGGAGCTCTTCGAAGAGATGCGCAGCACCAGGAGGGTGTCCGTGTGGCCCGTCGCC
TTCGTGGGTGGCCTGCGGTACGAGGCCCCACGGGTGAACGGGGCAGGGAAGGTGGTCCGC
TGGAAGACGGTGTTTGACCCCCACCGGCCATTTGCAATAGACATGGCTGGATTTGCCGTC
AACCTGCGGCTCATTCTGCAGCGAAGCCAGGCCTACTTCAAGCTGCGAGGTGTGAAGGGA
GGCTACCAGGAAAGCAGCCTCCTTCGAGAACTTGTCACCCTCAACGACCTGGAGCCCAAG
GCAGCCAACTGCACCAAGATCCTGGTGTGGCACACACGGACAGAGAAGCCAGTGCTGGTG
AATGAGGGCAAGAAGGGCTTCACTGACCCCTCGGTGGAGATCTGA

# Metabolic_Enzyme_37_GenBank_ID_Gene:
AB029396

# Metabolic_Enzyme_37_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_37_Locus:
11q25

# Metabolic_Enzyme_37_SNPs:
rs35434644; rs893952; rs1045721; rs729687; rs7951640; rs4937881; rs893951; rs11825422; rs877457; rs7103855; rs1866768; rs7928758; rs7929612; rs7948031; rs11823810; rs11826381; rs11822210; rs11825120; rs878987; rs11223780; rs1440483; rs7936835; rs7945585; rs893953; rs1866769; rs11825461; rs746430; rs11822935; rs7951463; rs11223785; rs11823028; rs2165313; rs7947989; rs7938186; rs10894810; rs7932600; rs5020292; rs7938108; rs11820747; rs877456; rs7938437; rs5020295; rs11820880; rs746431; rs893950; rs9734639; rs7109198; rs11602310; rs11823050; rs7108503; rs11600529; rs10894809; rs7948185; rs5020294; rs7938673; rs11821814; rs7108756; rs7938265; rs2076801; rs12416903; rs7108927; rs10894808; rs11822627; rs10791359; rs3065378; rs10894806; rs12806537; rs11820085; rs10894807; rs10894804; rs7113199; rs7939439; rs11223775; rs7112912; rs11223774; rs7939238; rs10894805; rs34954000; rs5020293; rs11824649; rs35370161; rs35872148; rs34702205; rs11410037; rs34403544; rs5020291; rs34416645; rs35181139; rs11223790; rs11223783; rs11351413; rs11351190; rs34368113; rs1062641; rs7938571; rs7109543; rs11223786; rs5020296; rs11821812; rs34747914; rs5020297; rs35474868; rs34063101; rs11223784; rs35061305; rs5795883; rs4548635; rs12803547; rs34606492; rs1866767; rs1078938; rs35574689; rs3824990; rs1978909; rs11223787; rs5020299; rs35652373; rs4937882; rs11223781; rs35717602; rs11607913; rs34518703; rs11600729; rs9735607; rs28402124; rs34856651; rs36085100; rs28378882; rs28625034; rs5020298; rs28647500; rs34122899; rs35796311; rs34108426; rs35939002; rs34648867; rs11223782; rs12417799; rs7128997; rs35259142; rs2360225; rs34599434; rs12803690; rs11822913; rs35305523; rs7108994; rs5795881; rs34593270; rs11223778; rs35439785; rs5795882; rs11223777; rs34277492; rs34236109; rs35111473; rs12419369; rs11223776; rs11826777; rs34110153; rs12363198; rs11223791; rs1042991; rs10791358; rs10894803; rs11223792; rs11223793; rs11223794; rs12808458; rs1440480; rs1440481; rs1440482; rs34063963; rs35217320; rs35321493; rs35804950; rs3741095; rs3741097; rs3741098; rs3741099; rs4937880; rs7120120; rs7122878; rs7937105; rs7950161; rs876542; rs876543; rs893947; rs9783402

# Metabolic_Enzyme_37_General_References:
10783264

# Metabolic_Enzyme_37_References:
12032138; 16709410

# Metabolic_Enzyme_38_ID:
6121

# Metabolic_Enzyme_38_Name:
Inositol oxygenase

# Metabolic_Enzyme_38_Synonyms:
Myo-inositol oxygenase; Aldehyde reductase-like 6; Renal-specific oxidoreductase; Kidney-specific protein 32

# Metabolic_Enzyme_38_Gene_Name:
MIOX

# Metabolic_Enzyme_38_Protein_Sequence:
>Inositol oxygenase
MKVTVGPDPSLVYRPDVDPEVAKDKASFRNYTSGPLLDRVFTTYKLMHTHQTVDFVRSKH
AQFGGFSYKKMTVMEAVDLLDGLVDESDPDVDFPNSFHAFQTAEGIRKAHPDKDWFHLVG
LLHDLGKVLALFGEPQWAVVGDTFPVGCRPQASVVFCDSTFQDNPDLQDPRYSTELGMYQ
PHCGLDRVLMSWGHDEYMYQVMKFNKFSLPPEAFYMIRFHSFYPWHTGRDYQQLCSQQDL
AMLPWVREFNKFDLYTKCPDLPDVDKLRPYYQGLIDKYCPGILSW

# Metabolic_Enzyme_38_Number_of_Residues:
285

# Metabolic_Enzyme_38_Molecular_Weight:
33010

# Metabolic_Enzyme_38_Theoretical_pI:
5.74

# Metabolic_Enzyme_38_GO_Classification:
Not Available

# Metabolic_Enzyme_38_General_Function:
Not Available

# Metabolic_Enzyme_38_Specific_Function:
Myo-inositol + O(2) = D-glucuronate + H(2)O

# Metabolic_Enzyme_38_Pathway:
map00562  Inositol phosphate metabolism

# Metabolic_Enzyme_38_Reaction:
myo-inositol + O2 = D-glucuronate + H2O

# Metabolic_Enzyme_38_Pfam_Domain_Function:
PF05153:DUF706

# Metabolic_Enzyme_38_Signals:
None

# Metabolic_Enzyme_38_Transmembrane_Regions:
None

# Metabolic_Enzyme_38_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_38_EC_Link:
EC 1.13.99.1

# Metabolic_Enzyme_38_GenBank_ID_Protein:
17932582

# Metabolic_Enzyme_38_SwissProt_ID:
MIOX_HUMAN (Q9UGB7)

# Metabolic_Enzyme_38_swissprot_Name:
Not Available

# Metabolic_Enzyme_38_Genecard_id:
MIOX

# Metabolic_Enzyme_38_Geneatlas_id:
MIOX

# Metabolic_Enzyme_38_hgnc_id:
HGNC:14522

# Metabolic_Enzyme_38_PDB_ID:
Not Available

# Metabolic_Enzyme_38_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_38_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_38_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_38_Gene_Sequence:
>858 bp
ATGAAGGTGACGGTGGGCCCAGACCCTTCCCTGGTCTACCGACCTGATGTGGACCCAGAG
GTGGCCAAAGACAAGGCCAGCTTCCGGAACTACACGTCAGGTCCCCTCCTGGACCGTGTC
TTCACCACCTACAAGCTCATGCACACGCACCAGACAGTGGACTTCGTCAGGAGCAAGCAT
GCCCAGTTTGGGGGCTTCTCCTACAAGAAAATGACAGTCATGGAGGCCGTGGACCTGCTG
GATGGGCTGGTGGATGAGTCGGACCCGGACGTAGATTTCCCCAACTCCTTCCATGCCTTC
CAGACAGCGGAGGGCATCCGGAAGGCCCACCCAGACAAGGACTGGTTCCACCTCGTCGGG
CTCCTGCACGACCTGGGGAAGGTCCTGGCCCTGTTCGGGGAGCCCCAGTGGGCTGTCGTC
GGCGACACCTTCCCCGTCGGATGCCGTCCGCAGGCCTCCGTGGTTTTCTGCGACTCCACC
TTCCAGGACAACCCTGACCTCCAGGATCCTCGATACAGCACAGAGCTCGGGATGTATCAG
CCCCACTGTGGGCTCGACAGGGTCCTCATGTCCTGGGGCCATGATGAGTACATGTACCAG
GTGATGAAGTTTAACAAGTTCTCACTGCCCCCTGAGGCTTTCTACATGATCCGGTTCCAC
TCCTTCTACCCCTGGCACACGGGCCGCGACTACCAGCAGCTGTGCAGCCAGCAGGACCTG
GCCATGCTGCCCTGGGTGCGGGAGTTCAACAAGTTCGACCTCTACACCAAGTGCCCGGAC
CTGCCGGACGTGGACAAGCTGCGGCCCTACTACCAGGGGCTCATTGACAAGTACTGCCCT
GGCATCCTGAGCTGGTGA

# Metabolic_Enzyme_38_GenBank_ID_Gene:
AY064416

# Metabolic_Enzyme_38_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_38_Locus:
22q13.3

# Metabolic_Enzyme_38_SNPs:
rs2232885; rs2232883; rs1055271; rs1064043; rs2232876; rs3747273; rs8140944; rs12484236; rs8138644; rs8136151; rs8136078; rs8140686; rs41280567; rs2232882; rs11556222; rs2232884; rs2232886; rs2232888; rs2232887; rs34472885; rs1055272; rs11705385; rs11705365; rs2232889; rs35968105; rs8142721; rs28478317; rs34136024; rs35664871; rs2232877; rs36033733; rs12484911; rs3747272; rs13056168; rs2232881; rs2232878; rs2232879; rs28433386; rs10538866; rs41280565; rs2232880; rs2232875; rs34404629; rs1138428; rs13053471; rs13055726; rs13056677; rs134975; rs2232871; rs2232872; rs2232873; rs2232874; rs2236031; rs2236032; rs2334100; rs34589122; rs35576574; rs4824156; rs4824157; rs6009971; rs6009974; rs6010108; rs761745; rs8138406; rs8141795; rs8141931; rs876278; rs9616854

# Metabolic_Enzyme_38_General_References:
10944187; 10591208

# Metabolic_Enzyme_38_References:
10572262

# Metabolic_Enzyme_39_ID:
8315

# Metabolic_Enzyme_39_Name:
UDP-glucuronosyltransferase 1-10 precursor

# Metabolic_Enzyme_39_Synonyms:
UDPGT; UGT1*10; UGT1-10; UGT1.10; UGT-1J; UGT1J

# Metabolic_Enzyme_39_Gene_Name:
UGT1A10

# Metabolic_Enzyme_39_Protein_Sequence:
>UDPglucuronosyltransferase 110 precursor
MARAGWTSPVPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLF
FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEG
AQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_39_Number_of_Residues:
530

# Metabolic_Enzyme_39_Molecular_Weight:
59810

# Metabolic_Enzyme_39_Theoretical_pI:
7.31

# Metabolic_Enzyme_39_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_39_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_39_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_39_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_39_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_39_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_39_Signals:
1-25

# Metabolic_Enzyme_39_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_39_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_39_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_39_GenBank_ID_Protein:
2039362

# Metabolic_Enzyme_39_SwissProt_ID:
UD110_HUMAN (Q9HAW8)

# Metabolic_Enzyme_39_swissprot_Name:
Not Available

# Metabolic_Enzyme_39_Genecard_id:
UGT1A10

# Metabolic_Enzyme_39_Geneatlas_id:
UGT1A10

# Metabolic_Enzyme_39_hgnc_id:
HGNC:12531

# Metabolic_Enzyme_39_PDB_ID:
Not Available

# Metabolic_Enzyme_39_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_39_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_39_Subcellular_Location:
Microsome

# Metabolic_Enzyme_39_Gene_Sequence:
>1593 bp
ATGGCTCCGCGCAGGGTGGACCAGCCCCGTTCCTTTATGTGTGTGTCTACTGCTGACCTG
TGGCTTTGCGAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGTCACTGGTTCGCC
ATGCAGTCGGTGGTGGAGAAACTTATCCTCAGGGGGCATGAGGTGGTTGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGAAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCG
TACACTCTGGAAGATCAGAACCGGGAATTCATGGTTTTCGCCCATGCTCAATGGAAAGCA
CAGGCACAAAGTATATTTTCTCTATTAATGAGTTCATCCAGTGGTTTTCTTGACTTATTT
TTTTCGCATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCAGTGTTTCTGGATCCTTTTGATACCTGTGGCTTAATTGTTGCTAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCACCAGGGGAATATTTTGCCGCCATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAATGATCTCTTAGGGTTCTCAGATGCC
ATGACTTTCAAGGAGAGAGTATGGAACCACATCGTGCACTTGGAGGACCATTTATTTTGC
CAGTATCTTTTAAGAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGTCACACATCAATTTGGTTGTTGCGAACGGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAACATGATCTTCATTGGTGGTATCAACTGTCATCAGGGA
AAGCCATTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_39_GenBank_ID_Gene:
U89508

# Metabolic_Enzyme_39_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_39_Locus:
2q37

# Metabolic_Enzyme_39_SNPs:
Not Available

# Metabolic_Enzyme_39_General_References:
9271343; 11434514

# Metabolic_Enzyme_39_References:
12124307; 12230871; 12867487; 17097115

# Macromolecular_Interacting_Partner_1_ID:
6003

# Macromolecular_Interacting_Partner_1_Name:
Gamma-glutamyltransferase-like protein 2

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
GGT2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Gammaglutamyltransferaselike protein 2
MTSEFFAAQLRSQISDHTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYG
ILFNNEWTTSALPAFTNEFGAPPSPANFIQPGKQPLLSMCLTIMVGQDGQVRMVVGAAGG
TQITTDTALAIIYNLWFGYDVKRAVEEPRLHNKLLPNVTTVERNIDQAVTAALETRHHHT
QIASTFIAVVQAIVRTAGGWAAALDSRKGGEPAGY

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
215

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
23152

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.85

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring amino-acyl groups
Function:  gamma-glutamyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01019:G_glu_transpept

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
GGTL2_HUMAN (P36268)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
GGT2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
GGT2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:4251

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AP000550

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_1_Locus:
22q11.21|22q11.1

# Macromolecular_Interacting_Partner_1_SNPs:
rs3984302; rs1055042; rs8139086; rs8140378; rs5747777; rs12157499; rs243423; rs16984529; rs4619710; rs531659; rs458129; rs3984335; rs3984362; rs615918; rs585882; rs3095824; rs4627683; rs3984348; rs2416648; rs3984350; rs524221; rs3984344; rs675932; rs3984359; rs429047; rs419876; rs3984347; rs425672; rs5747781; rs243430; rs712972; rs3893047; rs365982; rs243428; rs243429; rs370606; rs243431; rs2080690; rs5993280; rs3984324; rs243424; rs5742550; rs4619711; rs4532045; rs5992267; rs243422; rs3984309; rs3984322; rs645912; rs5993253; rs12163291; rs9605723; rs5747772; rs5992265; rs3984304; rs5747745; rs5993279; rs7289002; rs5993283; rs3984317; rs2330839; rs28454543; rs3984310; rs645874; rs5993281; rs12163068; rs28484915; rs5747773; rs3984323; rs3984308; rs3984320; rs4482586; rs5742291; rs5746592; rs3984307; rs28457127; rs5992266; rs28570688; rs445155; rs3984318; rs5992264; rs3984383; rs3962704; rs1682970; rs5992258; rs5747768; rs634241; rs5993260; rs12172311; rs5992261; rs3865661; rs3984340; rs11703106; rs3984377; rs415866; rs3984396; rs592227; rs592678; rs3984356; rs28432349; rs4453774; rs3984341; rs5747771; rs3962702; rs5993262; rs5993274; rs28545002; rs376710; rs3984328; rs5746589; rs9605714; rs3984369; rs3984381; rs12160828; rs3984332; rs5747751; rs12172441; rs3984343; rs3984354; rs3984365; rs527127; rs5993268; rs3984331; rs416172; rs5992255; rs3962683; rs3984326; rs5747761; rs618606; rs2416647; rs2544149; rs491974; rs28373739; rs9617727; rs3984370; rs3984367; rs3984373; rs407014; rs5747770; rs3984351; rs9605713; rs3095770; rs3984333; rs3865660; rs3962699; rs3852971; rs5993257; rs12172257; rs9605715; rs521558; rs3984342; rs3984349; rs431943; rs3984368; rs3894040; rs3984375; rs3095823; rs4532044; rs416669; rs5993273; rs5992262; rs678219; rs388369; rs391221; rs5742290; rs3984361; rs5747747; rs3984363; rs5747750; rs3894042; rs12160575; rs5993263; rs28676434; rs604301; rs3984338; rs3896619; rs5747759; rs3962701; rs5742579; rs5992260; rs5747769; rs5747760; rs439131; rs3984329; rs9604865; rs3962700; rs563090; rs3894044; rs3984345; rs5993261; rs3962682; rs3984382; rs3984371; rs9605710; rs3984364; rs3984352; rs3984339; rs604353; rs3984327; rs5992257; rs2544148; rs5747762; rs5747754; rs407275; rs5993278; rs5993258; rs391231; rs492871; rs3984372; rs5747764; rs5747755; rs3984366; rs12172258; rs5993267; rs5747749; rs3875899; rs5992263; rs3962705; rs5993259; rs7510731; rs28661417; rs413929; rs5747779; rs364896; rs444912; rs4621252; rs4819722; rs9618341; rs847019; rs3984403; rs363963; rs5747780; rs370956; rs7510856; rs12163131; rs243427

# Macromolecular_Interacting_Partner_1_General_References:
10591208; 2573352

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
7556

# Macromolecular_Interacting_Partner_2_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_2_Signals:
1-18

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_2_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_2_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_2_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_2_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_2_References:
10814882

# Macromolecular_Interacting_Partner_3_ID:
6120

# Macromolecular_Interacting_Partner_3_Name:
Beta-glucuronidase precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
Beta-G1

# Macromolecular_Interacting_Partner_3_Gene_Name:
GUSB

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Betaglucuronidase precursor
MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFE
EQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVV
LRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTT
LPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQD
SGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYL
YSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKG
FDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNN
VSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVT
FVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSE
YGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTR
VLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSLFT

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
651

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
74733

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
7.02

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_3_Specific_Function:
Plays an important role in the degradation of dermatan and keratan sulfates

# Macromolecular_Interacting_Partner_3_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00500  Starch and sucrose metabolism;
 map00531  Glycosaminoglycan degradation;
 map00860  Porphyrin and chlorophyll metabolism

# Macromolecular_Interacting_Partner_3_Reaction:
a beta-D-glucuronoside + H2O = D-glucuronate + an alcohol

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00703:Glyco_hydro_2;
PF02836:Glyco_hydro_2_C;
PF02837:Glyco_hydro_2_N

# Macromolecular_Interacting_Partner_3_Signals:
1-22

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
EC 3.2.1.31

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
183233

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
BGLR_HUMAN (P08236)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
GUSB

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
GUSB

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:4696

# Macromolecular_Interacting_Partner_3_PDB_ID:
1BHG

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Lysosome

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1956 bp
ATGGCCCGGGGGTCGGCGGTTGCCTGGGCGGCGCTCGGGCCGTTGTTGTGGGGCTGCGCG
CTGGGGCTGCAGGGCGGGATGCTGTACCCCCAGGAGAGCCCGTCGCGGGAGTGCAAGGAG
CTGGACGGCCTCTGGAGCTTCCGCGCCGACTTCTCTGACAACCGACGCCGGGGCTTCGAG
GAGCAGTGGTACCGGCGGCCGCTGTGGGAGTCAGGCCCCACCGTGGACATGCCAGTTCCC
TCCAGCTTCAATGACATCAGCCAGGACTGGCGTCTGCGGCATTTTGTCGGCTGGGTGTGG
TACGAACGGGAGGTGATCCTGCCGGAGCGATGGACCCAGGACCTGCGCACAAGAGTGGTG
CTGAGGATTGGCAGTGCCCATTCCTATGCCATCGTGTGGGTGAATGGGGTCGACACGCTA
GAGCATGAGGGGGGCTACCTCCCCTTCGAGGCCGACATCAGCAACCTGGTCCAGGTGGGG
CCCCTGCCCTCCCGGCTCCGAATCACTATCGCCATCAACAACACACTCACCCCCACCACC
CTGCCACCAGGGACCATCCAATACCTGACTGACACCTCCAAGTATCCCAAGGGTTACTTT
GTCCAGAACACATATTTTGACTTTTTCAACTACGCTGGACTGCAGCGGTCTGTACTTCTG
TACACGACACCCACCACCTACATCGATGACATCACCGTCACCACCAGCGTGGAGCAAGAC
AGTGGGCTGGTGAATTACCAGATCTCTGTCAAGGGCAGTAACCTGTTCAAGTTGGAAGTG
CGTCTTTTGGATGCAGAAAACAAAGTCGTGGCGAATGGGACTGGGACCCAGGGCCAACTT
AAGGTGCCAGGTGTCAGCCTCTGGTGGCCGTACCTGATGCACGAACGCCCTGCCTATCTG
TATTCATTGGAGGTGCAGCTGACTGCACAGACGTCACTGGGGCCTGTGTCTGACTTCTAC
ACACTCCCTGTGGGGATCCGCACTGTGGCTGTCACCAAGAGCCAGTTCCTCATCAATGGG
AAACCTTTCTATTTCCACGGTGTCAACAAGCATGAGGATGCGGACATCCGAGGGAAGGGC
TTCGACTGGCCGCTGCTGGTGAAGGACTTCAACCTGCTTCGCTGGCTTGGTGCCAACGCT
TTCCGTACCAGCCACTACCCCTATGCAGAGGAAGTGATGCAGATGTGTGACCGCTATGGG
ATTGTGGTCATCGATGAGTGTCCCGGCGTGGGCCTGGCGCTGCCGCAGTTCTTCAACAAC
GTTTCTCTGCATCACCACATGCAGGTGATGGAAGAAGTGGTGCGTAGGGACAAGAACCAC
CCCGCGGTCGTGATGTGGTCTGTGGCCAACGAGCCTGCGTCCCACCTAGAATCTGCTGGC
TACTACTTGAAGATGGTGATCGCTCACACCAAATCCTTGGACCCCTCCCGGCCTGTGACC
TTTGTGAGCAACTCTAACTATGCAGCAGACAAGGGGGCTCCGTATGTGGATGTGATCTGT
TTGAACAGCTACTACTCTTGGTATCACGACTACGGGCACCTGGAGTTGATTCAGCTGCAG
CTGGCCACCCAGTTTGAGAACTGGTATAAGAAGTATCAGAAGCCCATTATTCAGAGCGAG
TATGGAGCAGAAACGATTGCAGGGTTTCACCAGGATCCACCTCTGATGTTCACTGAAGAG
TACCAGAAAAGTCTGCTAGAGCAGTACCATCTGGGTCTGGATCAAAAACGCAGAAAATAT
GTGGTTGGAGAGCTCATTTGGAATTTTGCCGATTTCATGACTGAACAGTCACCGACGAGA
GTGCTGGGGAATAAAAAGGGGATCTTCACTCGGCAGAGACAACCAAAAAGTGCAGCGTTC
CTTTTGCGAGAGAGATACTGGAAGATTGCCAATGAAACCAGGTATCCCCACTCAGTAGCC
AAGTCACAATGTTTGGAAAACAGCCCGTTTACTTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
M15182

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_3_Locus:
7q21.11

# Macromolecular_Interacting_Partner_3_SNPs:
rs9530; rs1061361; rs2279903; rs2008188; rs781144; rs4718296; rs1880555; rs781143; rs1880556; rs12535204; rs4717280; rs6460266; rs17138062; rs12540589; rs12670952; rs781146; rs906134; rs1185223; rs10279841; rs781145; rs6955582; rs13245858; rs7800210; rs13228566; rs736270; rs7803283; rs7383796; rs12698510; rs34994057; rs781141; rs2279904; rs2961102; rs10245248; rs11559283; rs35302712; rs11559281; rs1723276; rs34983797; rs28669341; rs2949698; rs34970380; rs3105600; rs34277954; rs1701764; rs35248213; rs35244943; rs781142; rs6954920; rs35434779; rs35820085; rs34345393; rs10273958; rs11287621; rs10246998; rs2293340; rs3830444; rs4451200; rs28460798; rs7801713; rs34282416; rs937108; rs3061581; rs35197523; rs1626926; rs34611218; rs28667742; rs7786674; rs35542501; rs10229667; rs28628473; rs10238732; rs28418543; rs11355040; rs34606859; rs13226598; rs34275777; rs34025127; rs10274777; rs35957142; rs10807697; rs12538430; rs12698509; rs13230304; rs3735143; rs3735144; rs4504525; rs709607

# Macromolecular_Interacting_Partner_3_General_References:
3468507; 12853948; 1916806; 1311180; 3924735; 12754519; 8599764; 8111412; 8111413; 1702266; 7680524

# Macromolecular_Interacting_Partner_3_References:
10582697; 12569442

# Macromolecular_Interacting_Partner_4_ID:
7252

# Macromolecular_Interacting_Partner_4_Name:
Multidrug resistance-associated protein 1

# Macromolecular_Interacting_Partner_4_Synonyms:
ATP-binding cassette sub- family C member 1; Leukotriene C(4transporter; LTC4 transporter

# Macromolecular_Interacting_Partner_4_Gene_Name:
ABCC1

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Multidrug resistanceassociated protein 1
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITTLLA
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND
SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLAR
AVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIV
MSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGM
LVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL
SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG
ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL
DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL
KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA
VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA
VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG
EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF
SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCL
ARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVL
DKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
1531

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
171563

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
7.11

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  transporter activity
Function:  ATPase activity
Function:  hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Function:  ATPase activity, coupled to transmembrane movement of substances
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_4_Specific_Function:
May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Confers resistance to anticancer drugs. Transports LTC4. May protect milk against xenobiotics

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00664:ABC_membrane;
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
34-54
75-95
101-121
134-154
173-193
317-337
364-384
441-461
465-485
548-568
591-611
968-988
1026-1046
1090-1110
1112-1132
1204-1224
1227-1247

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
1835659

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
MRP1_HUMAN (P33527)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
ABCC1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
ABCC1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:51

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>4596 bp
ATGGCGCTCCGGGGCTTCTGCAGCGCCGATGGCTCCGACCCGCTCTGGGACTGGAATGTC
ACGTGGAATACCAGCAACCCCGACTTCACCAAGTGCTTTCAGAACACGGTCCTCGTGTGG
GTGCCTTGTTTTTACCTCTGGGCCTGTTTCCCCTTCTACTTCCTCTATCTCTCCCGACAT
GACCGAGGCTACATTCAGATGACACCTCTCAACAAAACCAAAACTGCCTTGGGATTTTTG
CTGTGGATCGTCTGCTGGGCAGACCTCTTCTACTCTTTCTGGGAAAGAAGTCGGGGCATA
TTCCTGGCCCCAGTGTTTCTGGTCAGCCCAACTCTCTTGGGCATCACCACGCTGCTTGCT
ACCTTTTTAATTCAGCTGGAGAGGAGGAAGGGAGTTCAGTCTTCAGGGATCATGCTCACT
TTCTGGCTGGTAGCCCTAGTGTGTGCCCTAGCCATCCTGAGATCCAAAATTATGACAGCC
TTAAAAGAGGATGCCCAGGTGGACCTGTTTCGTGACATCACTTTCTACGTCTACTTTTCC
CTCTTACTCATTCAGCTCGTCTTGTCCTGTTTCTCAGATCGCTCACCCCTGTTCTCGGAA
ACCATCCACGACCCTAATCCCTGCCCAGAGTCCAGCGCTTCCTTCCTGTCGAGGATCACC
TTCTGGTGGATCACAGGGTTGATTGTCCGGGGCTACCGCCAGCCCCTGGAGGGCAGTGAC
CTCTGGTCCTTAAACAAGGAGGACACGTCGGAACAAGTCGTGCCTGTTTTGGTAAAGAAC
TGGAAGAAGGAATGCGCCAAGACTAGGAAGCAGCCGGTGAAGGTTGTGTACTCCTCCAAG
GATCCTGCCCAGCCGAAAGAGAGTTCCAAGGTGGATGCGAATGAGGAGGTGGAGGCTTTG
ATCGTCAAGTCCCCACAGAAGGAGTGGAACCCCTCTCTGTTTAAGGTGTTATACAAGACC
TTTGGGCCCTACTTCCTCATGAGCTTCTTCTTCAAGGCCATCCACGACCTGATGATGTTT
TCCGGGCCGCAGATCTTAAAGTTGCTCATCAAGTTCGTGAATGACACGAAGGCCCCAGAC
TGGCAGGGCTACTTCTACACCGTGCTGCTGTTTGTCACTGCCTGCCTGCAGACCCTCGTG
CTGCACCAGTACTTCCACATCTGCTTCGTCAGTGGCATGAGGATCAAGACCGCTGTCATT
GGGGCTGTCTATCGGAAGGCCCTGGTGATCACCAATTCAGCCAGAAAATCCTCCACGGTC
GGGGAGATTGTCAACCTCATGTCTGTGGACGCTCAGAGGTTCATGGACTTGGCCACGTAC
ATTAACATGATCTGGTCAGCCCCCCTGCAAGTCATCCTTGCTCTCTACCTCCTGTGGCTG
AATCTGGGCCCTTCCGTCCTGGCTGGAGTGGCGGTGATGGTCCTCATGGTGCCCGTCAAT
GCTGTGATGGCGATGAAGACCAAGACGTATCAGGTGGCCCACATGAAGAGCAAAGACAAT
CGGATCAAGCTGATGAACGAAATTCTCAATGGGATCAAAGTGCTAAAGCTTTATGCCTGG
GAGCTGGCATTCAAGGACAAGGTGCTGGCCATCAGGCAGGAGGAGCTGAAGGTGCTGAAG
AAGTCTGCCTACCTGTCAGCCGTGGGCACCTTCACCTGGGTCTGCACGCCCTTTCTGGTG
GCCTTGTGCACATTTGCCGTCTACGTGACCATTGACGAGAACAACATCCTGGATGCCCAG
ACAGCCTTCGTGTCTTTGGCCTTGTTCAACATCCTCCGGTTTCCCCTGAACATTCTCCCC
ATGGTCATCAGCAGCATCGTGCAGGCGAGTGTCTCCCTCAAACGCCTGAGGATCTTTCTC
TCCCATGAGGAGCTGGAACCTGACAGCATCGAGCGACGGCCTGTCAAAGACGGCGGGGGC
ACGAACAGCATCACCGTGAGGAATGCCACATTCACCTGGGCCAGGAGCGACCCTCCCACA
CTGAATGGCATCACCTTCTCCATCCCCGAAGGTGCTTTGGTGGCCGTGGTGGGCCAGGTG
GGCTGCGGAAAGTCGTCCCTGCTCTCAGCCCTCTTGGCTGAGATGGACAAAGTGGAGGGG
CACGTGGCTATCAAGGGCTCCGTGGCCTATGTGCCACAGCAGGCCTGGATTCAGAATGAT
TCTCTCCGAGAAAACATCCTTTTTGGATGTCAGCTGGAGGAACCATATTACAGGTCCGTG
ATACAGGCCTGTGCCCTCCTCCCAGACCTGGAAATCCTGCCCAGTGGGGATCGGACAGAG
ATTGGCGAGAAGGGCGTGAACCTGTCTGGGGGCCAGAAGCAGCGCGTGAGCCTGGCCCGG
GCCGTGTACTCCAACGCTGACATTTACCTCTTCGATGATCCCCTCTCAGCAGTGGATGCC
CATGTGGGAAAACACATCTTTGAAAATGTGATTGGCCCCAAGGGGATGCTGAAGAACAAG
ACGCGGATCTTGGTCACGCACAGCATGAGCTACTTGCCGCAGGTGGACGTCATCATCGTC
ATGAGTGGCGGCAAGATCTCTGAGATGGGCTCCTACCAGGAGCTGCTGGCTCGAGACGGC
GCCTTCGCTGAGTTCCTGCGTACCTATGCCAGCACAGAGCAGGAGCAGGATGCAGAGGAG
AACGGGGTCACGGGCGTCAGCGGTCCAGGGAAGGAAGCAAAGCAAATGGAGAATGGCATG
CTGGTGACGGACAGTGCAGGGAAGCAACTGCAGAGACAGCTCAGCAGCTCCTCCTCCTAT
AGTGGGGACATCAGCAGGCACCACAACAGCACCGCAGAACTGCAGAAAGCTGAGGCCAAG
AAGGAGGAGACCTGGAAGCTGATGGAGGCTGACAAGGCGCAGACAGGGCAGGTCAAGCTT
TCCGTGTACTGGGACTACATGAAGGCCATCGGACTCTTCATCTCCTTCCTCAGCATCTTC
CTTTTCATGTGTAACCATGTGTCCGCGCTGGCTTCCAACTATTGGCTCAGCCTCTGGACT
GATGACCCCATCGTCAACGGGACTCAGGAGCACACGAAAGTCCGGCTGAGCGTCTATGGA
GCCCTGGGCATTTCACAAGGGATCGCCGTGTTTGGCTACTCCATGGCCGTGTCCATCGGG
GGGATCTTGGCTTCCCGCTGTCTGCACGTGGACCTGCTGCACAGCATCCTGCGGTCACCC
ATGAGCTTCTTTGAGCGGACCCCCAGTGGGAACCTGGTGAACCGCTTCTCCAAGGAGCTG
GACACAGTGGACTCCATGATCCCGGAGGTCATCAAGATGTTCATGGGCTCCCTGTTCAAC
GTCATTGGTGCCTGCATCGTTATCCTGCTGGCCACGCCCATCGCCGCCATCATCATCCCG
CCCCTTGGCCTCATCTACTTCTTCGTCCAGAGGTTCTACGTGGCTTCCTCCCGGCAGCTG
AAGCGCCTCGAGTCGGTCAGCCGCTCCCCGGTCTATTCCCATTTCAACGAGACCTTGCTG
GGGGTCAGCGTCATTCGAGCCTTCGAGGAGCAGGAGCGCTTCATCCACCAGAGTGACCTG
AAGGTGGACGAGAACCAGAAGGCCTATTACCCCAGCATCGTGGCCAACAGGTGGCTGGCC
GTGCGGCTGGAGTGTGTGGGCAACTGCATCGTTCTGTTTGCTGCCCTGTTTGCGGTGATC
TCCAGGCACAGCCTCAGTGCTGGCTTGGTGGGCCTCTCAGTGTCTTACTCATTGCAGGTC
ACCACGTACTTGAACTGGCTGGTTCGGATGTCATCTGAAATGGAAACCAACATCGTGGCC
GTGGAGAGGCTCAAGGAGTATTCAGAGACTGAGAAGGAGGCGCCCTGGCAAATCCAGGAG
ACAGCTCCGCCCAGCAGCTGGCCCCAGGTGGGCCGAGTGGAATTCCGGAACTACTGCCTG
CGCTACCGAGAGGACCTGGACTTCGTTCTCAGGCACATCAATGTCACGATCAATGGGGGA
GAAAAGGTCGGCATCGTGGGGCGGACGGGAGCTGGGAAGTCGTCCCTGACCCTGGGCTTA
TTTCGGATCAACGAGTCTGCCGAAGGAGAGATCATCATCGATGGCATCAACATCGCCAAG
ATCGGCCTGCACGACCTCCGCTTCAAGATCACCATCATCCCCCAGGACCCTGTTTTGTTT
TCGGGTTCCCTCCGAATGAACCTGGACCCATTCAGCCAGTACTCGGATGAAGAAGTCTGG
ACGTCCCTGGAGCTGGCCCACCTGAAGGACTTCGTGTCAGCCCTTCCTGACAAGCTAGAC
CATGAATGTGCAGAAGGCGGGGAGAACCTCAGTGTCGGGCAGCGCCAGCTTGTGTGCCTA
GCCCGGGCCCTGCTGAGGAAGACGAAGATCCTTGTGTTGGATGAGGCCACGGCAGCCGTG
GACCTGGAAACGGACGACCTCATCCAGTCCACCATCCGGACACAGTTCGAGGACTGCACC
GTCCTCACCATCGCCCACCGGCTCAACACCATCATGGACTACACAAGGGTGATCGTCTTG
GACAAAGGAGAAATCCAGGAGTACGGCGCCCCATCGGACCTCCTGCAGCAGAGAGGTCTT
TTCTACAGCATGGCCAAAGACGCCGGCTTGGTGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
L05628

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_4_Locus:
16p13.1

# Macromolecular_Interacting_Partner_4_SNPs:
rs13337489; rs246221; rs8187863; rs35605; rs2301666; rs9933640; rs35587; rs8187853; rs2239330; rs8187858; rs16967004; rs212090; rs129081; rs3743527; rs2644983; rs215101; rs246240; rs35592; rs152022; rs152029; rs215059; rs2014800; rs903880; rs35591; rs1967120; rs246217; rs2283515; rs937369; rs215074; rs2239996; rs246220; rs129116; rs212081; rs35628; rs35597; rs875740; rs35604; rs2062541; rs215063; rs212082; rs212087; rs215094; rs246232; rs8050836; rs4148333; rs117854; rs246230; rs246228; rs212085; rs246234; rs215100; rs1964656; rs35588; rs11864374; rs4781711; rs3851710; rs11861115; rs7188722; rs35621; rs4780585; rs35607; rs4148366; rs9932506; rs7189813; rs11075296; rs212084; rs171583; rs924138; rs35589; rs7198841; rs2238475; rs7188937; rs246214; rs119774; rs6498594; rs8052419; rs215075; rs4148355; rs212089; rs3851718; rs215049; rs9933511; rs4781708; rs7187319; rs173476; rs35595; rs3887893; rs215105; rs35610; rs2889517; rs152030; rs7190484; rs8054670; rs3851712; rs35623; rs246226; rs7204081; rs11861085; rs9332430; rs4148343; rs3784867; rs246215; rs35596; rs215099; rs185005; rs8048316; rs2269800; rs8061136; rs7185286; rs215052; rs246219; rs2074086; rs4781712; rs246212; rs3851711; rs8059648; rs35620; rs11075293; rs193538; rs8054156; rs3784864; rs35629; rs3887412; rs3851719; rs6498591; rs11642957; rs246238; rs2384938; rs215098; rs12923345; rs8045309; rs1964657; rs16967126; rs3784862; rs12921748; rs246218; rs246222; rs215077; rs12934692; rs7404127; rs7188177; rs6498595; rs12445600; rs2283512; rs17501011; rs152032; rs4780589; rs8044115; rs17287570; rs215087; rs4148354; rs35625; rs9673292; rs17215768; rs35618; rs35594; rs2283516; rs17205859; rs11865361; rs4781699; rs7198766; rs452277; rs215088; rs246235; rs2384939; rs4780592; rs9932856; rs8047359; rs40427; rs35615; rs152027; rs215058; rs17501331; rs16967173; rs924135; rs6498597; rs35626; rs9932395; rs8049010; rs9932097; rs8053266; rs11861014; rs215096; rs8051963; rs17579406; rs2889518; rs11075291; rs4781727; rs35619; rs4780591; rs6498590; rs9635480; rs35606; rs152033; rs1153867; rs2074087; rs35601; rs152260; rs4781724; rs12921924; rs11075292; rs7203145; rs7196296; rs2238474; rs8048428; rs8054099; rs6498593; rs16967758; rs16967096; rs17265551; rs4781718; rs4148361; rs11861804; rs3851717; rs8058379; rs246241; rs11865571; rs16967145; rs215085; rs11866794; rs215066; rs1874001; rs16967227; rs11647513; rs7198932; rs903881; rs17264736; rs4148358; rs7189529; rs10852377; rs35627; rs11862504; rs2299670; rs182482; rs12924212; rs6498592; rs11075290; rs152028; rs152031; rs9938317; rs165975; rs8050637; rs7202970; rs12444264; rs4781716; rs7195031; rs12708802; rs2074085; rs215090; rs7197317; rs246236; rs11075289; rs35612; rs4148344; rs3851713; rs7201642; rs4780593; rs13332486; rs17579503; rs12921623; rs3888565; rs8187860; rs16967755; rs3765129; rs215086; rs4781701; rs924137; rs7196970; rs8048485; rs7201361; rs35614; rs7200100; rs3819552; rs12449241; rs6416665; rs11075295; rs11860247; rs35599; rs3216337; rs13335850; rs152023; rs35622; rs4148353; rs11861765; rs2644990; rs4148375; rs3844217; rs12922744; rs8055903; rs11645172; rs9923585; rs215091; rs7199424; rs215095; rs7193363; rs246229; rs7189316; rs11862407; rs9927099; rs4781709; rs12596469; rs215076; rs7196112; rs3851708; rs193537; rs7197383; rs16967179; rs9933152; rs9921168; rs16967046; rs3837750; rs3851716; rs248417; rs762775; rs1809815; rs4781700; rs12447386; rs215106; rs8056499; rs16955252; rs215053; rs8057422; rs215064; rs6498598; rs4781715; rs4148337; rs149541; rs4148346; rs762778; rs3784863; rs4148376; rs169984; rs11645782; rs2270490; rs12924026; rs7198391; rs8055510; rs17205838; rs215050; rs8058078; rs12927980; rs35602; rs11640751; rs246233; rs4781710; rs3888568; rs246223; rs456640; rs9931401; rs11075297; rs4148331; rs3851715; rs13331142; rs8059482; rs9927011; rs458926; rs8057596; rs12930197; rs215061; rs11866350; rs12929789; rs4148340; rs215054; rs3851709; rs215092; rs9933592; rs4781714; rs12922588; rs11863132; rs12447005; rs762777; rs11075288; rs35593; rs17841264; rs215079; rs4148351; rs152024; rs246213; rs215067; rs4148373; rs997691; rs215062; rs215051; rs215060; rs12927675; rs7198872; rs11861837; rs9928852; rs35616; rs4148335; rs13339242; rs9938526; rs10775291; rs215072; rs215089; rs35624; rs9931103; rs8057590; rs4781721; rs17205398; rs212079; rs8047227; rs7192281; rs8063599; rs215108; rs150530; rs4781720; rs1472532; rs35611; rs3932161; rs12446785; rs12922404; rs215055; rs8047871; rs215078; rs4781717; rs11865161; rs7193261; rs2283514; rs212083; rs169985; rs6498596; rs215103; rs246227; rs215057; rs17287542; rs4780586; rs937367; rs3784860; rs8062525; rs3851714; rs8058040; rs8059503; rs9934297; rs212088; rs13332140; rs35609; rs8047230; rs215068; rs212086; rs12599429; rs16966996; rs6498599; rs4780584; rs7198319; rs8046737; rs7186901; rs8053946; rs13335227; rs2644989; rs152025; rs35613; rs2283511; rs8046950; rs35600; rs4238623; rs4781722; rs4148362; rs11075298; rs13336889; rs4148336; rs12935283; rs215097; rs246237; rs924136; rs215056; rs4148349; rs11865349; rs35598; rs12449239; rs5016527; rs16967135; rs212080; rs8060750; rs2239995; rs4148359; rs215073; rs12447187; rs35590; rs6416666; rs7498870; rs9935678; rs12928602; rs7195815; rs3784861; rs10852378; rs7195962; rs11640684; rs9673916; rs35608; rs2238476; rs13333810; rs212091; rs4148380; rs504348; rs4148330; rs8056298; rs41395947; rs41410450; rs8057331; rs4148356; rs28706727; rs41494447; rs4148377; rs12596095; rs35840440; rs11647037; rs435683; rs7202416; rs36027088; rs2047591; rs8047497; rs28535049; rs36032323; rs35752420; rs7187052; rs3072717; rs28431874; rs34993915; rs34549440; rs12927511; rs34833276; rs12917894; rs13337533; rs35358180; rs10638507; rs9935219; rs35705679; rs10614463; rs9927479; rs4148363; rs13333388; rs7501384; rs4148371; rs4781728; rs12920011; rs35727154; rs11860365; rs28377922; rs12934657; rs35006643; rs28814960; rs12920817; rs5815853; rs215070; rs215065; rs35874442; rs5815856; rs11393636; rs10543560; rs33981753; rs35046517; rs4780588; rs5815852; rs34673924; rs35160852; rs6498601; rs28852806; rs34873364; rs4781707; rs10644540; rs9929609; rs13332722; rs2376956; rs34220492; rs35240096; rs28600754; rs11397057; rs3837749; rs4148368; rs12926867; rs12934266; rs9932205; rs35418200; rs35711628; rs12921067; rs35240251; rs28489119; rs13339669; rs35076831; rs13332852; rs165974; rs35241718; rs10438544; rs34334712; rs215080; rs13337581; rs34184710; rs12923217; rs35662370; rs34417580; rs28502346; rs11866942; rs11647533; rs28844882; rs34365293; rs8054963; rs10636969; rs9940699; rs393915; rs4479256; rs8055122; rs41278166; rs12920754; rs35229595; rs34555174; rs1108573; rs215109; rs13334390; rs12918259; rs34155371; rs35666498; rs11862552; rs10634703; rs11643934; rs34712007; rs4148364; rs12928233; rs11287273; rs12924449; rs12926589; rs10577554; rs11441919; rs10526186; rs7498869; rs35219631; rs34044736; rs12923333; rs35081755; rs34550012; rs35201502; rs10591001; rs215104; rs34485846; rs150529; rs4781719; rs11441920; rs7404359; rs12920923; rs35208396; rs9936158; rs11282335; rs34528514; rs34905861; rs2385154; rs35207136; rs5815854; rs35096356; rs35694522; rs4148369; rs7205368; rs10543561; rs35804420; rs7188711; rs35978240; rs28661219; rs11410221; rs8058069; rs7195265; rs9922649; rs35600720; rs12927259; rs246225; rs34275813; rs3837751; rs10712722; rs28662320; rs1690409; rs35090860; rs4646414; rs9933212; rs34159339; rs12447413; rs28710234; rs1690410; rs12935384; rs4148360; rs10694441; rs34530270; rs11373213; rs12443966; rs10656206; rs28393114; rs3072761; rs10673887; rs34085651; rs11427239; rs8062040; rs215048; rs34026115; rs9936155; rs33916796; rs35534532; rs5815850; rs34627014; rs34325137; rs11311843; rs34655471; rs34914361; rs34817873; rs35167276; rs11274450; rs4148350; rs11380982; rs34820524; rs34761300; rs35092337; rs410375; rs35694269; rs34630818; rs28753779; rs35490080; rs34313407; rs7192604; rs35086205; rs11277270; rs12933642; rs12925569; rs371941; rs35246390; rs12929025; rs35151447; rs35928400; rs35167165; rs28505554; rs35327998; rs5815857; rs34346901; rs7194547; rs36108316; rs11317464; rs34600200; rs34770208; rs246224; rs10673886; rs34123416; rs34383577; rs7498133; rs3851720; rs12934619; rs7193196; rs35525424; rs8062912; rs34982921; rs10555145; rs35254618; rs35193854; rs4115669; rs12926865; rs11640365; rs3080589; rs34334486; rs5815858; rs34479623; rs11325281; rs35126918; rs35367430; rs34868583; rs3072678; rs34536387; rs34557574; rs215069; rs12920474; rs12919829; rs34358165; rs28695591; rs9932986; rs34292006; rs35704526; rs35802304; rs35378917; rs34575102; rs12934210; rs12149248; rs246239; rs3072682; rs34897139; rs149320; rs34115753; rs7192845; rs4148347; rs9674124; rs8057769; rs11371659; rs35347382; rs11284065; rs8050655; rs34443742; rs17289179; rs12918323; rs35810367; rs11269394; rs35419413; rs35420214; rs34650655; rs35956116; rs34936105; rs35600994; rs6416667; rs12929024; rs12934905; rs17289158; rs28722680; rs2014793; rs1153866; rs12449077; rs34752935; rs3743526; rs35747063; rs34872698; rs8044628; rs35437608; rs11644918; rs4148348; rs12596360; rs35058919; rs4148332; rs34654774; rs41280868; rs10589853; rs36056963; rs10580146; rs11642737; rs10716039; rs7193755; rs152261; rs4520863; rs35609874; rs35869759; rs13329759; rs35851401; rs34074243; rs34575460; rs4148370; rs34490863; rs10532060; rs13334396; rs11327128; rs11343915; rs34482500; rs12917903; rs12934085; rs34466025; rs11639546; rs28592191; rs3830390; rs9923248; rs1690411; rs35471843; rs4780590; rs16967727; rs34789916; rs35133979; rs12934491; rs1874473; rs35983738; rs35101141; rs35252822; rs2283513; rs28501979; rs9889088; rs9929703; rs11323592; rs34788606; rs4459564; rs35384983; rs7193245; rs12934472; rs4646415; rs35685006; rs12927524; rs34005060; rs9931487; rs28515006; rs11647389; rs12050956; rs35692393; rs34742430; rs35708071; rs762776; rs13337279; rs5815855; rs34781067; rs35494993; rs35163690; rs41278168; rs12929883; rs13380679; rs7194549; rs35273939; rs12933311; rs28723466; rs490294; rs10706261; rs35493923; rs2384937; rs36080634; rs34754847; rs28561819; rs35605618; rs215102; rs7193525; rs34024385; rs4780594; rs28367505; rs11863228; rs13332325; rs11281850; rs12934805; rs8045000; rs4148367; rs5815851; rs6145768; rs10568708; rs35617; rs11644882; rs7202715; rs34870561; rs10673197; rs11320744; rs35791790; rs7196697; rs4497718; rs4148342; rs11416711; rs35962196; rs11304106; rs34692171; rs34935265; rs10598360; rs28735920; rs35603; rs6498600; rs215107; rs11416710; rs34985714; rs12925671; rs34292394; rs3072683; rs1697157; rs7205077; rs8064014; rs34714018; rs35601346; rs8058245; rs12232450; rs7199834; rs35481775; rs11430158; rs11291616; rs12930255; rs7197454; rs215093; rs28435381; rs34360190; rs8058920; rs4148378; rs28450757; rs35473382; rs4780587; rs10648689; rs416821; rs35118593; rs979560; rs34692126; rs7404210; rs11399369; rs12917672; rs4148365; rs34233722; rs28449253; rs34088403; rs34566056; rs11449114; rs35335689; rs34381428; rs34089889; rs12929977; rs11075299; rs12448760; rs16967632; rs212093; rs212094; rs212097; rs212098; rs2238473; rs28364001; rs28364002; rs34288338; rs34526519; rs34545444; rs35148086; rs35934123; rs35939983; rs3902401; rs4148382; rs6498603; rs7192634; rs8047642; rs8050881; rs8062278; rs8187843; rs8187844; rs8187845; rs8187846; rs8187848; rs8187849; rs8187850; rs8187851; rs8187854; rs8187855; rs8187856; rs8187857; rs8187859; rs8187861; rs8187862

# Macromolecular_Interacting_Partner_4_General_References:
1360704; 8098549; 8649356; 9344662; 10493829; 9295302; 9334225; 9485377; 11114332; 11469806; 11278867; 10835642; 10811882; 11721885; 11139250; 11266082

# Macromolecular_Interacting_Partner_4_References:
11898391; 15501592

End of HMDB00127

Beginning of HMDB00128
# Accession_No:
HMDB00128

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-18 21:02:01

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Guanidoacetic acid

# Description:
Metabolite in the Urea cycle and metabolism of amino groups, and in the metabolic pathways of several amino acids.  This includes glycine, serine, threonine, arginine and proline metabolism. Guanidinoacetic acid is also a precursor of creatine, an essential substrate for muscle energy metabolism.

# Synonyms:
(carboxymethyl)-Guanidine; 2-[[Amino(imino)methyl]amino]acetate; 2-[[Amino(imino)methyl]amino]acetic acid; Betacyamine; Betasyamine; Glycocyamine; Guanidineacetate; Guanidineacetic acid; Guanidinoacetate; Guanidinoacetic acid; Guanidoacetate; Guanidoacetic acid; Guanidylacetate; Guanidylacetic acid; Guanyl glycine; N-Amidinoglycine; N-amidino-Glycine; [(aminoiminomethyl)amino]-Acetate; [(aminoiminomethyl)amino]-Acetic acid; a-Guanidinoacetate; a-Guanidinoacetic acid; b-Guanidinoacetate; b-Guanidinoacetic acid; alpha-Guanidinoacetate; alpha-Guanidinoacetic acid; beta-Guanidinoacetate; beta-Guanidinoacetic acid

# Chemical_IUPAC_Name:
Glycine, N-(aminoiminomethyl)-

# Chemical_Formula:
C3H7N3O2

# Chemical_Structure:
tbl_chemical:::HMDB00128_ZOOM.png:::119283206426312640

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00128_THUMB.png:::119283206269818648

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Nitrogenous Compounds

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
carboxylic acid; guanidine

# Taxonomy_Biofunction:
Component of Arginine and proline metabolism; Component of Glycine, serine and threonine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
117.05383

# Molecular_Weight_Avg:
117.10658

# Smiles_String_isomeric:
NC(=N)NCC(O)=O

# Smiles_String_canonical:
NC(=N)NCC(O)=O

# KEGG_Compound_ID:
C00581

# BioCyc_ID:
GUANIDOACETIC_ACID

# PubChem_CID:
763

# PubChem_SID:
2778; 7889432; 152827; 3860; 87230; 132058; 10332393; 608263; 8137780; 585666; 3133363; 8143426; 68629; 7980745; 5324533

# OMIM_ID:
601240; 602360

# Metagene_ID:
Not Available

# BiGG_ID:
1594816

# Wikipedia_ID:
Not Available

# METLIN_ID:
5163

# Ref_ID:
12701824; 16855203; 8547310; 15234333; 9367508; 16343968; 15369749; 12661026; 15028668; 8651275; 3815805; 3433275; 11749046; 7808840

# ChEBI_ID:
16344

# CAS_Registry_Number:
352-97-6

# InChI:
InChI=1/C3H7N3O2/c4-3(5)6-1-2(7)8/h1H2,(H,7,8)(H4,4,5,6)

# Synthesis_Reference:
A facile conversion of amino acids to guanidino acids.     Miller, Audrey E.; Bischoff, Judith J.    Dep. Chem.,  Univ. Connecticut,  Storrs,  CT,  USA.    Synthesis  (1986),   (9),  777-9.

# Melting_Point:
Not Available

# Melting_Point_predicted:
35.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
3.6 mg/mL at 15 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
4.19 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-1.75 [Predicted by ALOGPS]; -1.8 [Predicted by PubChem via XLOGP]; -3.93 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Guanidoacetic acid.pdf:::1132562203854656312

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Guanidoacetic_acid.mol:::1132723808703410080

# SDF_File_[Text]:
tbl_chemical:::HMDB00128.sdf:::119283205956547013

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00128.pdb:::11928320613006342

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::guanidoacetic_acid.FID:::11424659468987222

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::guanidoacetic_acid.png:::114246594694496994

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::050117_P00_05_BA_1DC_101.jpg:::11416839223198547

# C_NMR_FIDS_Spectra:
tbl_cnmr:::050117_P00_05_BA_1DC_101.zip:::114168392227713864

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::050117_P00_05_BA_1DC_101_Assigned.jpg:::116016254167565523

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050117_P00_05_BA_2DHSQC_47.jpg:::114617779238272807

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041020_P00_04_HW_2DHSQC_47.zip:::114617779239752652

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050117_P00_05_BA_2DHSQC_47_Assigned.jpg:::115384187515050676

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Guanidoacetic acid.gif:::113273211190624693

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00128_peaks.txt:::1156309563761635952

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Guanidoacetic acid_C.gif:::1132737693279592973

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00128_peaks.txt:::1156310753784883118

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00128L.png:::117555262710927429; Medium Energy:tbl_ms:::HMDB00128M.png:::117555268087047879; High Energy:tbl_ms:::HMDB00128H.png:::117555271517649068

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP)

# Tissue_Location:
Brain; Kidney; Liver

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Cellular Cytoplasm; Urine

# Concentration_[Normal]:
Urine	89.0 (11.0-124.0)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	12661026
Urine	88.5 (18.0-159.0)	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	15369749
Urine	74.0 (18.0-130.0)	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	15369749
Blood	19.0 (3.0 - 37.0)	umol/L	Adult:>18_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 91. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	0 - 5.0	uM	Adult:>18_yrs_old	Both	Normal	12661026
Cerebrospinal_Fluid(CSF)	0.05 +/- 0.03	umol/L	Adult:>18_yrs_old	Both	Normal	3433275
Cellular_Cytoplasm	2.3 +/- 0.9	umol/L	Adult:>18_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 91. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Hyperargininemia

# Pathway_Names:
Glycerolipid metabolism;Glycerophospholipid metabolism

# Pathway_Images:
;

# KEGG_Images:
map00561;map00564

# Pathway_Graphs:
;

# Pathway_SBMLs:
;

# Metabolic_Enzyme_1_ID:
6116

# Metabolic_Enzyme_1_Name:
Glycerol kinase, testis specific 2

# Metabolic_Enzyme_1_Synonyms:
ATP:glycerol 3- phosphotransferase; Glycerokinase; GK

# Metabolic_Enzyme_1_Gene_Name:
GK2

# Metabolic_Enzyme_1_Protein_Sequence:
>Glycerol kinase, testis specific 2
MAAPKTAAVGPLVGAVVQGTNSTRFLVFNSKTAELLSHHKVELTQEFPKEGWVEQDPKEI
LQSVYECIARTCEKLDELNIDISNIKAVGVSNQRETTVIWDKLTGEPLYNAVVWLDLRTQ
TTVEDLSKKIPGNSNFVKSKTGLPLSTYFSAVKLRWMLDNVRNVQKAVEEGRALFGTIDS
WLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKELCDFFEIPMDLLPNVFSSSEIY
GLIKTGALEGVPISGCLGDQCAALVGQMCFQEGQAKNTYGTGCFLLCNTGRKCVFSEHGL
LTTVAYKLGREKPAYYALEGSVAIAGAVIRWLRDNLGIIETSGDIERLAKEVGTSYGCYF
VPAFSGLYAPYWEPSARGILCGLTQFTNKCHIAFAALEAVCFQTREILEAMNRDCGIPLR
HLQVDGGMTNNKVLMQLQADILHIPVIKPFMPETTALGAAMAAGAAEGVSVWSLEPQALS
VLRMERFEPQIQATESEIRYATWKKAVMKSMGWVTSQSPEGGDPSIFCSLPLGFFIVSSM
VMLIGARYISGVP

# Metabolic_Enzyme_1_Number_of_Residues:
553

# Metabolic_Enzyme_1_Molecular_Weight:
60610

# Metabolic_Enzyme_1_Theoretical_pI:
5.53

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  glycerol kinase activity
 ||
>>>
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  polyol metabolism
Process:  glycerol metabolism
Process:  glycerol-3-phosphate metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
Key enzyme in the regulation of glycerol uptake and metabolism

# Metabolic_Enzyme_1_Pathway:
map00561  Glycerolipid metabolism

# Metabolic_Enzyme_1_Reaction:
ATP + glycerol = ADP + sn-glycerol 3-phosphate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF02782:FGGY_C;
PF00370:FGGY_N

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.7.1.30

# Metabolic_Enzyme_1_GenBank_ID_Protein:
516124

# Metabolic_Enzyme_1_SwissProt_ID:
GLPK2_HUMAN (Q14410)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
GK2

# Metabolic_Enzyme_1_Geneatlas_id:
GK2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4291

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; peripheral membrane protein; cytoplasmic side. Cytoplasm (By similarity). Note=In sperm the majority of the enzyme is bound to mitochondria (By similarity)

# Metabolic_Enzyme_1_Gene_Sequence:
>1662 bp
ATGGCAGCCCCAAAGACAGCAGCTGTGGGGCCGTTGGTGGGAGCGGTGGTCCAGGGCACC
AACTCCACTCGCTTTCTGGTTTTCAATTCAAAAACAGCGGAACTACTTAGTCATCACAAA
GTGGAATTAACACAAGAGTTTCCAAAAGAAGGATGGGTGGAACAAGACCCTAAAGAAATT
CTTCAGTCTGTCTACGAGTGTATAGCGAGAACGTGTGAGAAACTTGACGAACTGAATATT
GATATATCCAACATAAAAGCTGTTGGTGTCAGCAATCAGAGGGAAACCACTGTAATCTGG
GACAAGTTAACAGGAGAGCCTCTCTACAATGCTGTGGTGTGGCTTGATCTAAGAACCCAG
ACTACTGTTGAGGATCTTAGTAAAAAAATTCCAGGAAATAGTAACTTCGTCAAGTCTAAG
ACAGGCCTTCCACTCAGCACTTACTTCAGTGCAGTAAAACTTCGTTGGATGCTTGACAAT
GTGAGAAACGTCCAAAAGGCTGTTGAAGAAGGTAGAGCTCTTTTTGGTACCATTGATTCA
TGGCTTATCTGGAGTTTGACAGGAGGAGTTAATGGAGGCGTGCATTGTACAGATGTAACA
AATGCAAGTAGGACAATGCTTTTTAATATCCATTCTTTGGAATGGGATAAAGAGCTCTGT
GACTTTTTTGAAATTCCAATGGACCTTCTTCCAAATGTCTTCAGTTCTTCTGAGATCTAT
GGCCTAATTAAAACTGGAGCCCTGGAAGGTGTGCCAATATCTGGGTGTTTGGGGGACCAA
TGTGCTGCATTAGTAGGACAAATGTGCTTCCAGGAGGGACAAGCCAAAAACACCTATGGA
ACAGGTTGCTTCTTACTGTGTAATACGGGTCGTAAATGTGTGTTTTCTGAACATGGCCTT
TTGACCACAGTAGCTTACAAACTAGGCAGAGAGAAGCCAGCATATTATGCACTGGAAGGT
TCTGTTGCTATAGCAGGTGCTGTTATTCGTTGGCTAAGAGACAATCTTGGAATTATAGAG
ACCTCAGGAGACATTGAAAGACTTGCTAAAGAAGTAGGAACTTCTTATGGCTGTTACTTT
GTCCCAGCCTTTTCAGGGTTATATGCACCTTATTGGGAGCCCAGTGCAAGAGGGATACTC
TGTGGCCTCACTCAGTTTACCAATAAATGTCATATTGCTTTTGCTGCATTAGAAGCTGTT
TGTTTCCAAACCCGAGAGATTTTGGAAGCCATGAACCGAGACTGTGGAATTCCACTTCGT
CATTTGCAGGTAGATGGAGGAATGACCAACAACAAAGTTCTTATGCAGCTACAAGCAGAT
ATTCTTCATATTCCAGTAATAAAACCCTTTATGCCTGAAACAACTGCACTAGGAGCTGCC
ATGGCAGCAGGGGCTGCAGAGGGAGTAAGCGTTTGGAGCCTTGAACCCCAGGCTTTGTCA
GTTCTCAGGATGGAACGATTTGAACCACAGATCCAGGCCACAGAAAGTGAAATTCGTTAT
GCCACATGGAAGAAAGCCGTAATGAAGTCAATGGGTTGGGTTACCAGTCAGTCTCCTGAA
GGTGGTGATCCTTCTATCTTCTGTAGTCTGCCTTTGGGATTTTTTATAGTGAGTAGCATG
GTAATGCTAATTGGAGCAAGATATATCTCGGGTGTGCCATAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X78712

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_1_Locus:
4q13

# Metabolic_Enzyme_1_SNPs:
rs6837906; rs34557444; rs1922285; rs10003904; rs4975086; rs17443219; rs10222878; rs7673905; rs1052314; rs11747; rs34499878; rs1238687; rs28459916; rs12499035; rs10222755; rs10049840; rs11930550; rs13113953; rs17003749; rs17003752; rs1882509; rs34310456; rs4627893; rs6837049

# Metabolic_Enzyme_1_General_References:
7987308

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5429

# Metabolic_Enzyme_2_Name:
Glycerol-3-phosphate dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_2_Synonyms:
GPD-M; GPDH-M; mtGPD

# Metabolic_Enzyme_2_Gene_Name:
GPD2

# Metabolic_Enzyme_2_Protein_Sequence:
>Glycerol3phosphate dehydrogenase, mitochondrial precursor
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQMNLAYVKAADCISEPVNREPPSREAQ
LLTLQNTSEFDILVIGGGATGSGCALDAVTRGLKTALVERDDFSSGTSSRSTKLIHGGVR
YLQKAIMKLDIEQYRMVKEALHERANLLEIAPHLSAPLPIMLPVYKWWQLPYYWVGIKLY
DLVAGSNCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYG
AATANYMEVVSLLKKTDPQTGKVHVSGARCKDVLTGQEFDVRAKCVINATGPFTDSVRKM
DDKDAAAICQPSAGVHIVMPGYYSPESMGLLDPATSDGRVIFFLPWQKMTIAGTTDTPTD
VTHHPIPSEEDINFILNEVRNYLSCDVEVRRGDVLAAWSGIRPLVTDPKSADTQSISRNH
VVDISESGLITIAGGKWTTYRSMAEDTINAAVKTHNLKAGPSRTVGLFLQGGKDWSPTLY
IRLVQDYGLESEVAQHLAATYGDKAFEVAKMASVTGKRWPIVGVRLVSEFPYIEAEVKYG
IKEYACTAVDMISRRTRLAFLNVQAAEEALPRIVELMGRELNWDDYKKQEQLETARKFLY
YEMGYKSRSEQLTDRSEISLLPSDIDRYKKRFHKFDADQKGFITIVDVQRVLESINVQMD
ENTLHEILNEVDLNKNGQVELNEFLQLMSAIQKGRVSGSRLAILMKTAEENLDRRVPIPV
DRSCGGL

# Metabolic_Enzyme_2_Number_of_Residues:
727

# Metabolic_Enzyme_2_Molecular_Weight:
80835

# Metabolic_Enzyme_2_Theoretical_pI:
7.58

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  glycerol-3-phosphate dehydrogenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  electron transport
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  polyol metabolism
Process:  glycerol metabolism
Process:  glycerol-3-phosphate metabolism
 ||
>>>
Component:  protein complex
Component:  unlocalized protein complex
Component:  glycerol-3-phosphate dehydrogenase complex

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor

# Metabolic_Enzyme_2_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_2_Reaction:
sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01266:DAO;
PF00036:efhand

# Metabolic_Enzyme_2_Signals:
1-23

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.99.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
533693

# Metabolic_Enzyme_2_SwissProt_ID:
GPDM_HUMAN (P43304)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
GPD2

# Metabolic_Enzyme_2_Geneatlas_id:
GPD2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:4456

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_2_Gene_Sequence:
>2184 bp
ATGGCATTTCAAAAGGCAGTGAAAGGGACGATTCTTGTTGGAGGAGGTGCTCTTGCAACT
GTTTTAGGACTTTCTCAGTTTGCTCATTACAGAAGGAAACAAATGAACCTGGCCTATGTT
AAAGCAGCAGACTGCATTTCAGAACCAGTTAACAGGGAGCCTCCTTCCAGAGAAGCTCAG
CTACTGACTTTGCAAAACACATCTGAATTTGATATCCTTGTTATTGGAGGAGGAGCAACA
GGAAGTGGCTGTGCGCTAGATGCTGTCACCAGAGGACTAAAAACAGCCCTTGTAGAAAGA
GATGATTTCTCATCAGGGACCAGCAGCAGAAGCACTAAATTGATCCATGGTGGTGTGAGA
TATCTGCAGAAGGCCATCATGAAGTTGGATATTGAGCAGTATAGGATGGTAAAAGAAGCC
CTTCATGAGCGTGCCAACCTGCTAGAAATTGCTCCCCATTTATCAGCTCCATTGCCTATA
ATGCTTCCAGTTTACAAGTGGTGGCAGTTACCTTACTACTGGGTAGGAATCAAGCTGTAT
GATTTGGTTGCAGGAAGCAATTGCCTAAAAAGCAGTTATGTCCTCAGCAAATCAAGAGCC
CTTGAACATTTCCCAATGCTCCAGAAGGACAAACTGGTAGGAGCAATTGTCTACTATGAC
GGACAACATAACGATGCACGGATGAACCTTGCCATTGCTCTGACTGCTGCCAGGTATGGG
GCTGCCACAGCCAATTACATGGAGGTAGTGAGCTTGCTCAAGAAGACAGACCCCCAGACA
GGGAAAGTGCATGTGAGCGGCGCACGGTGCAAGGATGTCCTCACAGGGCAGGAATTTGAC
GTGAGAGCCAAATGTGTTATCAATGCCACGGGACCTTTCACGGACTCTGTGCGCAAAATG
GATGATAAAGACGCAGCAGCTATCTGCCAGCCAAGTGCTGGTGTCCATATTGTGATGCCT
GGTTATTACAGCCCAGAGAGCATGGGACTTCTTGACCCAGCGACCAGTGATGGGCGAGTT
ATTTTCTTCTTACCCTGGCAAAAGATGACGATCGCTGGCACTACTGATACTCCAACTGAT
GTTACACACCATCCAATTCCTTCAGAAGAAGATATCAACTTCATTTTGAATGAAGTGCGT
AATTACCTGAGTTGTGATGTTGAAGTGAGAAGAGGGGATGTCCTGGCAGCATGGAGTGGA
ATCCGTCCTCTTGTTACAGACCCCAAATCTGCAGATACTCAGTCTATCTCCCGAAATCAT
GTTGTTGATATCAGTGAGAGTGGCCTTATTACTATAGCAGGTGGAAAGTGGACAACTTAT
CGGTCTATGGCAGAAGATACCATAAATGCTGCTGTCAAAACTCATAATTTAAAAGCAGGA
CCAAGTAGAACAGTTGGGCTTTTCCTTCAAGGGGGTAAAGATTGGAGCCCCACACTCTAC
ATTAGGCTTGTGCAGGATTATGGACTTGAAAGCGAGGTGGCACAGCATCTTGCCGCCACC
TATGGTGATAAGGCCTTTGAGGTGGCCAAAATGGCAAGTGTGACTGGCAAAAGGTGGCCT
ATTGTTGGAGTACATCTTGTGTCAGAATTTCCATATATTGAAGCAGAGGTGAAATATGGG
ATTAAGGAGTATGCCTGCACTGCTGTGGATATGATTTCACGTCGTACTCGCCTGGCCTTT
CTAAATGTCCAGGCAGCAGAGGAAGCCCTACCCAGGATTGTTGAACTGATGGGCAGGGAA
CTGAATTGGGATGATTATAAGAAGCAGGAACAACTTGAAACAGCCAGGAAGTTTCTATAT
TATGAAATGGGCTATAAATCTCGATCAGAACAGTTAACAGATCGCTCTGAAATTAGCCTA
CTGCCTTCAGACATTGACAGGTATAAGAAGAGATTTCATAAGTTTGATGCAGACCAGAAA
GGCTTTATTACCATTGTTGATGTTCAGCGTGTATTAGAGAGTATCAATGTCCAAATGGAT
GAAAATACACTCCATGAAATTCTAAATGAAGTTGATTTGAATAAAAATGGACAGGTTGAA
CTCAATGAATTTTTGCAGCTGATGAGTGCTATTCAAAAAGGAAGGGTATCTGGAAGCCGG
CTTGCTATACTAATGAAAACTGCAGAAGAGAACCTCGACAGAAGAGTTCCAATTCCAGTG
GACCGTAGTTGTGGAGGATTGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
U12424

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_2_Locus:
2q24.1

# Metabolic_Enzyme_2_SNPs:
rs2116665; rs35096779; rs17266469; rs298291; rs298261; rs298289; rs298262; rs298305; rs298228; rs2615502; rs298311; rs298259; rs298252; rs298229; rs6732240; rs4664207; rs4635480; rs298258; rs298254; rs12694631; rs6728547; rs683747; rs298253; rs298292; rs3754772; rs6721605; rs4664816; rs2169504; rs298285; rs10497166; rs12694629; rs298266; rs11899734; rs298239; rs298309; rs4664820; rs1037961; rs298235; rs298306; rs298300; rs298238; rs4664818; rs298290; rs298233; rs298310; rs298264; rs298256; rs690998; rs548516; rs12618695; rs11694661; rs298255; rs298251; rs298303; rs298308; rs298231; rs2126457; rs595383; rs13382767; rs4423559; rs298260; rs11690274; rs10176599; rs177087; rs6739324; rs13425879; rs298234; rs10804320; rs298257; rs13430640; rs2126460; rs298263; rs2679206; rs298236; rs4664206; rs1347095; rs11883845; rs298286; rs177089; rs12104533; rs2126459; rs10933038; rs16840353; rs298265; rs298237; rs1469650; rs1469652; rs298224; rs962497; rs182431; rs1560629; rs1462376; rs1821227; rs297581; rs1878769; rs297595; rs526540; rs297587; rs1548024; rs297578; rs1347099; rs298281; rs298226; rs1469653; rs7570567; rs4664208; rs3769366; rs297597; rs2116664; rs192716; rs3769369; rs3769371; rs2352096; rs7588004; rs2568816; rs7607845; rs962496; rs1560628; rs3769368; rs297588; rs3769358; rs571785; rs9288592; rs297599; rs7578131; rs1368249; rs542355; rs4664821; rs3769364; rs10933056; rs4664822; rs7558733; rs297598; rs1982059; rs6744480; rs297579; rs1432575; rs7590718; rs2288760; rs3769370; rs692187; rs1469651; rs3754769; rs297589; rs1548023; rs12615570; rs2017539; rs297586; rs13396538; rs9711295; rs12474824; rs3769359; rs4664823; rs7579092; rs6732175; rs17200880; rs297592; rs1347098; rs10195257; rs17251686; rs3754770; rs16840461; rs17266406; rs297591; rs7599290; rs3769357; rs297596; rs3769361; rs2352098; rs298227; rs3820857; rs297590; rs9288604; rs6725987; rs10182361; rs487265; rs4664827; rs159514; rs690945; rs4664826; rs297594; rs4425039; rs655387; rs4330074; rs16840520; rs17266034; rs7559338; rs11901848; rs16840460; rs4629116; rs13391591; rs297593; rs16840468; rs4664825; rs297585; rs212905; rs12475999; rs7605841; rs3769362; rs11681927; rs3835848; rs3769367; rs16840481; rs1347096; rs3769373; rs10169318; rs3769350; rs16840411; rs6436494; rs691594; rs13424996; rs17199901; rs691637; rs13399570; rs11885397; rs3835847; rs7591462; rs6436493; rs297584; rs4425038; rs7556729; rs4597465; rs7569343; rs297583; rs9677998; rs298296; rs6747945; rs6750643; rs298294; rs6718963; rs298293; rs4664815; rs1051916; rs17847139; rs1804593; rs34974356; rs1467187; rs2679203; rs691227; rs34875231; rs298307; rs590754; rs475756; rs1975902; rs298232; rs10180527; rs17847141; rs34796510; rs2675712; rs35794755; rs7567350; rs3055091; rs11336166; rs34523958; rs11429300; rs7606799; rs10445739; rs35144943; rs188467; rs2679204; rs690663; rs691293; rs34691868; rs10933036; rs34771172; rs184913; rs10657222; rs509529; rs298288; rs10656929; rs298230; rs35511543; rs691294; rs35904731; rs509624; rs298240; rs2679205; rs34394250; rs34453109; rs298304; rs2675711; rs11695216; rs34497949; rs298301; rs35667385; rs550521; rs298287; rs34143262; rs11344919; rs35319889; rs507701; rs11358703; rs2679202; rs11673870; rs34135682; rs11695217; rs1711316; rs34556972; rs10933039; rs34083461; rs11306300; rs298302; rs1467186; rs35926444; rs35159143; rs5835626; rs34738359; rs33996425; rs518846; rs9712277; rs11368130; rs16840406; rs4031587; rs35642582; rs11334036; rs34739770; rs35527416; rs35555006; rs7558850; rs190940; rs28452808; rs35478289; rs7589387; rs5835621; rs34108342; rs28499504; rs34262953; rs41492145; rs5835617; rs13398783; rs34379946; rs13398548; rs7422253; rs297582; rs2288759; rs35946145; rs2675710; rs34211909; rs12994777; rs34963495; rs34823055; rs6757255; rs36066165; rs7586190; rs3835846; rs10208665; rs186137; rs36012397; rs17847138; rs10192500; rs34181184; rs13423974; rs34509913; rs7423051; rs35395426; rs10539711; rs3086039; rs691304; rs11900457; rs519659; rs34812340; rs35563986; rs11347902; rs13427301; rs35262236; rs35362867; rs34969077; rs10550156; rs1347097; rs5835622; rs35583977; rs34524248; rs11416758; rs35132156; rs2675709; rs5835615; rs513156; rs7425277; rs13431443; rs11334405; rs2288758; rs33997077; rs35948070; rs691843; rs35710754; rs13433023; rs11317393; rs34460742; rs35686791; rs13398546; rs36035384; rs10192526; rs35120661; rs11276820; rs10707919; rs5835619; rs3835845; rs36093756; rs34925801; rs16840400; rs35808251; rs3769354; rs11320789; rs34208301; rs3769347; rs1982058; rs10610989; rs35297244; rs35780226; rs297580; rs5835624; rs9711450; rs10199812; rs5835616; rs11314446; rs36218647; rs10626259; rs508189; rs10191672; rs10552676; rs13008880; rs35906072; rs35817705; rs11320467; rs7422659; rs11429008; rs34936714; rs13431442; rs35120803; rs691395; rs5835620; rs35670405; rs167231; rs34181246; rs6740886; rs35426018; rs34544631; rs35428648; rs10623253; rs34270896; rs35060849; rs13385778; rs36035034; rs7422636; rs3769353; rs11339030; rs692330; rs34280846; rs7560365; rs7600038; rs17847143; rs11682756; rs17265464; rs35007922; rs34501947; rs34331054; rs34247779; rs13012464; rs3053178; rs34554584; rs35587559; rs35763581; rs5835627; rs192715; rs35453329; rs34693625; rs1821229; rs13412325; rs28551173; rs36082652; rs11686540; rs2436305; rs34707341; rs691924; rs34797022; rs9808437; rs33967607; rs7422938; rs5835625; rs34275702; rs3180749; rs17847137; rs13034619; rs34363930; rs28490992; rs16840470; rs298295; rs13417897; rs34826316; rs10497165; rs1368246; rs1368247; rs1368248; rs1432573; rs1432574; rs17201069; rs17266971; rs177088; rs1922; rs193382; rs1991776; rs2043259; rs298222; rs298223; rs3739110; rs3916984; rs691591; rs7563588; rs7607531; rs9646877

# Metabolic_Enzyme_2_General_References:
7821823; 8549872; 9110174

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6117

# Metabolic_Enzyme_3_Name:
Glycerol kinase

# Metabolic_Enzyme_3_Synonyms:
ATP:glycerol 3-phosphotransferase; Glycerokinase; GK

# Metabolic_Enzyme_3_Gene_Name:
GK

# Metabolic_Enzyme_3_Protein_Sequence:
>Glycerol kinase
MAASKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEI
LHSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKITGEPLYNAVVWLDLRTQ
STVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEKRALFGTIDS
WLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKQLCEFFGIPMEILPNVRSSSEIY
GLMKAGALEGVPISGCLGDQSAALVGQMCFQIGQAKNTYGTGCFLLCNTGHKCVFSDHGL
LTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKTSEEIEKLAKEVGTSYGCYF
VPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLS
HLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLS
AVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSPESGIP

# Metabolic_Enzyme_3_Number_of_Residues:
524

# Metabolic_Enzyme_3_Molecular_Weight:
57490

# Metabolic_Enzyme_3_Theoretical_pI:
6.25

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  glycerol kinase activity
 ||
>>>
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  polyol metabolism
Process:  glycerol metabolism
Process:  glycerol-3-phosphate metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
Key enzyme in the regulation of glycerol uptake and metabolism

# Metabolic_Enzyme_3_Pathway:
map00561  Glycerolipid metabolism

# Metabolic_Enzyme_3_Reaction:
ATP + glycerol = ADP + sn-glycerol 3-phosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF02782:FGGY_C;
PF00370:FGGY_N

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.7.1.30

# Metabolic_Enzyme_3_GenBank_ID_Protein:
348167

# Metabolic_Enzyme_3_SwissProt_ID:
GLPK_HUMAN (P32189)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
GK

# Metabolic_Enzyme_3_Geneatlas_id:
GK

# Metabolic_Enzyme_3_hgnc_id:
HGNC:4289

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; peripheral membrane protein; cytoplasmic side. Cytoplasm. Note=In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>1575 bp
ATGGCAGCCTCAAAGAAGGCAGTTTTGGGGCCATTGGTGGGGGCGGTGGACCAGGGCACC
AGTTCGACGCGCTTTTTGGTTTTCAATTCAAAAACAGCTGAACTACTTAGTCATCATCAA
GTAGAAATAAAACAAGAGTTCCCAAGAGAAGGATGGGTGGAACAGGACCCTAAGGAAATT
CTACATTCTGTCTATGAGTGTATAGAGAAAACATGTGAGAAACTTGGACAGCTCAATATT
GATATTTCCAACATAAAAGCTATTGGTGTCAGCAACCAGAGGGAAACCACTGTAGTCTGG
GACAAGATAACTGGAGAGCCTCTCTACAATGCTGTGGTGTGGCTTGATCTAAGAACCCAG
TCTACCGTTGAGAGTCTTAGTAAAAGAATTCCAGGAAATAATAACTTTGTCAAGTCCAAG
ACAGGCCTTCCACTTAGCACTTACTTCAGTGCAGTGAAACTTCGTTGGCTCCTTGACAAT
GTGAGAAAAGTTCAAAAGGCCGTTGAAGAAAAACGAGCTCTTTTTGGGACTATTGATTCA
TGGCTTATTTGGAGTTTGACAGGAGGAGTCAATGGAGGTGTCCACTGTACAGATGTAACA
AATGCAAGTAGGACTATGCTTTTCAACATTCATTCTTTGGAATGGGATAAACAACTCTGC
GAATTTTTTGGAATTCCAATGGAAATTCTTCCAAATGTCCGGAGTTCTTCTGAGATCTAT
GGCCTAATGAAAGCTGGGGCCTTGGAAGGTGTGCCAATATCTGGGTGTTTAGGGGACCAG
TCTGCTGCATTGGTGGGACAAATGTGCTTCCAGATTGGACAAGCCAAAAATACGTATGGA
ACAGGATGTTTCTTACTATGTAATACAGGCCATAAGTGTGTATTTTCTGATCATGGCCTT
CTCACCACAGTGGCTTACAAACTTGGCAGAGACAAACCAGTATATTATGCTTTGGAAGGT
TCTGTAGCTATAGCTGGTGCTGTTATTCGCTGGCTAAGAGACAATCTTGGAATTATAAAG
ACCTCAGAAGAAATTGAAAAACTTGCTAAAGAAGTAGGTACTTCTTATGGCTGCTACTTC
GTCCCAGCATTTTCGGGGTTATATGCACCTTATTGGGAGCCCAGCGCAAGAGGGATAATC
TGTGGACTCACTCAGTTCACCAATAAATGCCATATTGCTTTTGCTGCATTAGAAGCTGTT
TGTTTCCAAACTCGAGAGATTTTGGATGCCATGAATCGAGACTGTGGAATTCCACTCAGT
CATTTGCAGGTAGATGGAGGAATGACCAGCAACAAAATTCTTATGCAGCTACAAGCAGAC
ATTCTGTATATACCAGTAGTGAAGCCCTCAATGCCCGAAACCACTGCACTGGGTGCGGCT
ATGGCGGCAGGGGCTGCAGAAGGAGTCGGCGTATGGAGTCTCGAACCCGAGGATTTGTCT
GCCGTCACGATGGAGCGGTTTGAACCTCAGATTAATGCGGAGGAAAGTGAAATTCGTTAT
TCTACATGGAAGAAAGCTGTGATGAAGTCAATGGGTTGGGTTACAACTCAATCTCCAGAA
AGTGGTATTCCATAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
L13943

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_3_Locus:
Xp21.3

# Metabolic_Enzyme_3_SNPs:
rs17854202; rs34795481; rs5926945; rs1803659; rs5972222; rs931240; rs5927582; rs6527003; rs619; rs728149; rs4636357; rs12844553; rs4487947; rs6527002; rs5972211; rs5927593; rs1482834; rs6526991; rs5927587; rs6526997; rs5927596; rs5927584; rs4077820; rs12843585; rs967785; rs5927589; rs5972207; rs4609338; rs12560212; rs6526996; rs5926944; rs5927595; rs2868571; rs5926942; rs5972213; rs2035432; rs620; rs12854653; rs12011728; rs16989176; rs1871965; rs7058925; rs7878037; rs5927585; rs16989169; rs5927594; rs6526995; rs5972206; rs6631156; rs12010068; rs4617310; rs12007993; rs5972204; rs5971513; rs12851094; rs5972202; rs7879845; rs2035431; rs4345726; rs5972203; rs12557274; rs5927588; rs12009986; rs5927590; rs5926943; rs5927581; rs5927599; rs2170611; rs11095189; rs17854203; rs17857267; rs5927597; rs5972217; rs5972215; rs5927598; rs5972216; rs5926946; rs3931219; rs5972219; rs34867477; rs5972221; rs5972220; rs5972218; rs41302637; rs34792758; rs35918035; rs35586363; rs36091656; rs41305205; rs34365099; rs10644351; rs4829198; rs5971511; rs34992170; rs41311819; rs34773549; rs6631159; rs35313243; rs34172820; rs35124133; rs6631151; rs10682299; rs6631142; rs34474761; rs35688593; rs35784640; rs5927591; rs35182768; rs5927580; rs28366724; rs35849427; rs34275810; rs12847609; rs6631141; rs6628544; rs5971512; rs35027105; rs5927586; rs6631158; rs5926938; rs35498618; rs35856351; rs5926941; rs6631155; rs10656820; rs35354095; rs35120364; rs5927592; rs35987506; rs35931680; rs4415475; rs11281728; rs5926940; rs11306027; rs6631140; rs34129824; rs35468110; rs12007023; rs28697906; rs6631157; rs6631144; rs35791116; rs5972209; rs28390198; rs41309689; rs34160985; rs5926939; rs35547075; rs3838210; rs41311491; rs12843247; rs12845821; rs35183149; rs35290317; rs12007026; rs3747459; rs5972210; rs5972205; rs11282593; rs6631143; rs11349869; rs36091714; rs34474103; rs6631161; rs34088900; rs12007087; rs6631146; rs11417266; rs35182714; rs12862589; rs34301411; rs36133772; rs12844258; rs11461651; rs12011679; rs4486355; rs6631150; rs11400828; rs34773915; rs3838209; rs34462788; rs12007053; rs2868570; rs5927606; rs5927607; rs5972224; rs6526989; rs6527012; rs6653843; rs7049882

# Metabolic_Enzyme_3_General_References:
8401584; 7987308; 8499912; 8499898; 8651297; 9719371; 10736265

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
6118

# Metabolic_Enzyme_4_Name:
Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic

# Metabolic_Enzyme_4_Synonyms:
GPD-C; GPDH-C

# Metabolic_Enzyme_4_Gene_Name:
GPD1

# Metabolic_Enzyme_4_Protein_Sequence:
>Glycerol3phosphate dehydrogenase NAD+, cytoplasmic
MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHEN
VKYLPGHKLPPNVVAVPDVVQAAEDADILIFVVPHQFIGKICDQLKGHLKANATGISLIK
GVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCETTIGCKDPAQGQLLKEL
MQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAK
LFCSGPVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGP
ETARELYSILQHKGLVDKFPLFMAVYKVCYEGQPVGEFIHCLQNHPEHM

# Metabolic_Enzyme_4_Number_of_Residues:
349

# Metabolic_Enzyme_4_Molecular_Weight:
37568

# Metabolic_Enzyme_4_Theoretical_pI:
6.10

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  glycerol-3-phosphate dehydrogenase (NAD+) activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
 ||
>>>
Process:  glycerol-3-phosphate catabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  polyol metabolism
Process:  glycerol metabolism
Process:  glycerol-3-phosphate metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm
Component:  protein complex
Component:  unlocalized protein complex
Component:  glycerol-3-phosphate dehydrogenase complex

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH

# Metabolic_Enzyme_4_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_4_Reaction:
sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF07479:NAD_Gly3P_dh_C;
PF01210:NAD_Gly3P_dh_N

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.1.1.8

# Metabolic_Enzyme_4_GenBank_ID_Protein:
508487

# Metabolic_Enzyme_4_SwissProt_ID:
GPDA_HUMAN (P21695)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
GPD1

# Metabolic_Enzyme_4_Geneatlas_id:
GPD1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:4455

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_4_Gene_Sequence:
>1050 bp
ATGGCTAGCAAGAAAGTCTGCATTGTAGGCTCCGGGAACTGGGGCTCAGCCATCGCCAAG
ATCGTGGGTGGCAATGCAGCCCAGCTCGCACAGTTTGACCCACGGGTGACCATGTGGGTA
TTTGAGGAAGACATTGGAGGCAAAAAGCTGACTGAGATCATCAACACGCAGCATGAGAAT
GTCAAATACCTGCCAGGGCACAAGTTGCCCCCAAATGTGGTGGCTGTCCCAGATGTGGTC
CAGGCTGCAGAGGATGCTGACATCCTGATCTTTGTGGTGCCCCATCAGTTCATCGGCAAG
ATCTGTGACCAGCTCAAGGGCCATCTGAAGGCAAACCCCACTGGCATATCTCTTATTAAG
GGGGTAGACGAGGGCCCCAATGGGCTGAAGCTCATCTCGGAAGTGATTGGGGAGCGCCTC
GGCATCCCCATGAGTGTGCTGATGGGGGCCAACATTGCCAGCGAGGTGGCTGATGAGAAG
TTCTGTGAGACAACCATTGGCTGCAAGGACCCGGCCCAGGGACAACTCCTGAAAGAGCTG
ATGCAGACACCAAACTTCCGTATCACAGTGGTGCAAGAGGTGGACACAGTAGAGATCTGT
GGAGCCTTAAAGAATGTAGTGGCCGTGGGGGCTGGCTTCTGTGATGGCCTGGGCTTTGGC
GACAACACCAAGGCGGCAGTGATCCGGCTGGGACTCATGGAGATGATAGCCTTCGCCAAG
CTCTTCTGCAGTGGCCCTGTGTCCTCTGCCACCTTCTTGGAGAGCTGTGGTGTTGCTGAC
CTGATCACTACCTGCTATGGAGGGCGGAACCGGAAAGTGGCTGAGGCCTTTGCGCGTACA
GGAAAGTCCATTGAGCAGCTGGAGAAAGAGTTGCTGAATGGGCAGAAACTGCAGGGGCCC
GAGACAGCCCGGGAGCTATACAGCATCCTCCAGCACAAGGGCCTGGTAGACAAGTTTCCC
TTGTTCATGGCTGTGTACAAGGTGTGCTACGAGGGCCAGCCAGTGGGTGAATTCATCCAC
TGCCTGCAGAATCATCCAGAACATATGTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
L34041

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_4_Locus:
12q12-q13

# Metabolic_Enzyme_4_SNPs:
rs2232202; rs836180; rs836178; rs836179; rs2232208; rs1128867; rs35428353; rs34944386; rs11541968; rs2232207; rs34783513; rs1046194; rs17848998; rs34423210; rs34013306; rs35256655; rs34005044; rs2232203; rs17848997; rs2232206; rs2232205; rs34537997; rs34025341; rs17848999; rs34926030; rs2232209; rs2232204; rs17848996; rs3813525; rs3841318; rs3813524; rs1050728; rs1050729; rs1059627; rs1063528; rs10817; rs12309742; rs1389280; rs1554844; rs17124432; rs17124448; rs7139363; rs7307230; rs7308474; rs7961065; rs7961112; rs7968119; rs836172; rs836177

# Metabolic_Enzyme_4_General_References:
7772607; 2398890

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
6119

# Metabolic_Enzyme_5_Name:
Glycerol-3-phosphate acyltransferase, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
GPAT

# Metabolic_Enzyme_5_Gene_Name:
GPAM

# Metabolic_Enzyme_5_Protein_Sequence:
>Glycerol3phosphate acyltransferase, mitochondrial precursor
MDESALTLGTIDVSYLPHSSEYSVGRCKHTSEEWGECGFRPTIFRSATLKWKESLMSRKR
PFVGRCCYSCTPQSWDKFFNPSIPSLGLRNVIYINETHTRHRGWLARRLSYVLFIQERDV
HKGMFATNVTENVLNSSRVQEAIAEVAAELNPDGSAQQQSKAVNKVKKKAKRILQEMVAT
VSPAMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLT
FILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRLDETPDGRKDVLYRALLHGHI
VELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSTNVIPDILIIPVGISYDRII
EGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGCVRVDFAQPFSLKEYLESQSQKPVSA
LLSLEQALLPAILPSRPSDAADEGRDTSINESRNATDESLRRRLIANLAEHILFTASKSC
AIMSTHIVACLLLYRHRQGIDLSTLVEDFFVMKEEVLARDFDLGFSGNSEDVVMHAIQLL
GNCVTITHTSRNDEFFITPSTTVPSVFELNFYSNGVLHVFIMEAIIACSLYAVLNKRGLG
GPTSTPPNLISQEQLVRKAASLCYLLSNEGTISLPCQTFYQVCHETVGKFIQYGILTVAE
HDDQEDISPSLAEQQWDKKLPEPLSWRSDEEDEDSDFGEEQRDCYLKVSQSKEHQQFITF
LQRLLGPLLEAYSSAAIFVHNFSGPVPEPEYLQKLHKYLITRTERNVAVYAESATYCLVK
NAVKMFKDIGVFKETKQKRVSVLELSSTFLPQCNRQKLLEYILSFVVL

# Metabolic_Enzyme_5_Number_of_Residues:
828

# Metabolic_Enzyme_5_Molecular_Weight:
93796

# Metabolic_Enzyme_5_Theoretical_pI:
7.78

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  O-acyltransferase activity
Function:  glycerol-3-phosphate O-acyltransferase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
Process:  membrane lipid metabolism
Process:  phospholipid metabolism
Process:  phospholipid biosynthesis
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_5_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1- acyl-sn-glycerol 3-phosphate

# Metabolic_Enzyme_5_Pathway:
map00561  Glycerolipid metabolism;
 map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_5_Reaction:
acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01553:Acyltransferase

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
472-494
575-593

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.3.1.15

# Metabolic_Enzyme_5_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_5_SwissProt_ID:
PLSB_HUMAN (Q9HCL2)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
GPAM

# Metabolic_Enzyme_5_Geneatlas_id:
GPAM

# Metabolic_Enzyme_5_hgnc_id:
HGNC:24865

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; multi-pass membrane protein

# Metabolic_Enzyme_5_Gene_Sequence:
Not Available

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AL391986

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_5_Locus:
10q25.2

# Metabolic_Enzyme_5_SNPs:
rs2792751; rs10787428; rs35019520; rs2277207; rs2254537; rs34047745; rs1129555; rs2297991; rs7078775; rs17129557; rs12146169; rs2792703; rs2251579; rs2255141; rs2254532; rs2803616; rs10885313; rs2792736; rs1807800; rs2487294; rs7897449; rs6585138; rs10749111; rs2803619; rs7074861; rs7083112; rs10749108; rs3824626; rs2250802; rs2900943; rs2803618; rs7898897; rs2255400; rs2792735; rs2803608; rs2050856; rs7899096; rs17129561; rs2803609; rs10736219; rs4918720; rs10885314; rs17129571; rs7094703; rs17129577; rs5024318; rs2803621; rs7093217; rs7089231; rs6585139; rs2251697; rs17129583; rs3740148; rs3740149; rs10787427; rs2792700; rs2297992; rs7920165; rs1986438; rs2803613; rs2792759; rs4918721; rs12783877; rs6585140; rs10749109; rs11195832; rs2001808; rs2263608; rs3824627; rs2419604; rs17129552; rs11195836; rs2900942; rs34740406; rs11549703; rs12252659; rs17852829; rs34215277; rs11304218; rs35347280; rs11592340; rs41292608; rs7074014; rs35511341; rs1832712; rs11195831; rs35116854; rs4918718; rs11195834; rs2803615; rs2792693; rs34031033; rs35533692; rs35719646; rs2066222; rs3832660; rs4918719; rs2803610; rs11407962; rs2792737; rs3216019; rs2792734; rs2792692; rs35513817; rs41292610; rs3052612; rs2803620; rs41313471; rs2803617; rs2803612; rs2792732; rs2792739; rs35704531; rs5787948; rs36041321; rs34829947; rs10589809; rs2803611; rs34978775; rs35674832; rs10749110; rs2792733; rs35858569; rs34043766; rs9420128; rs4917627; rs35110499; rs11429255; rs34256116; rs2803614; rs35417372; rs2792738; rs11195837; rs2792740; rs7085428; rs2792741; rs35521996; rs11195835; rs35958288; rs34171826; rs10787429; rs11195829; rs11195830; rs11598741; rs12773815; rs2419603; rs2792742; rs2792743; rs2792744; rs2803605; rs4917628; rs4918722; rs4918723; rs7083222; rs7084039; rs7094828; rs7096937; rs7358161; rs7358165

# Metabolic_Enzyme_5_General_References:
10997877

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5702

# Metabolic_Enzyme_6_Name:
Glycine amidinotransferase, mitochondrial precursor

# Metabolic_Enzyme_6_Synonyms:
L- arginine:glycine amidinotransferase; Transamidinase; AT

# Metabolic_Enzyme_6_Gene_Name:
GATM

# Metabolic_Enzyme_6_Protein_Sequence:
>Glycine amidinotransferase, mitochondrial precursor
MLRVRCLRGGSRGAEAVHYIGSRLGRTLTGWVQRTFQSTQAATASSRNSCAADDKATEPL
PKDCPVSSYNEWDPLEEVIVGRAENACVPPFTIEVKANTYEKYWPFYQKQGGHYFPKDHL
KKAVAEIEEMCNILKTEGVTVRRPDPIDWSLKYKTPDFESTGLYSAMPRDILIVVGNEII
EAPMAWRSRFFEYRAYRSIIKDYFHRGAKWTTAPKPTMADELYNQDYPIHSVEDRHKLAA
QGKFVTTEFEPCFDAADFIRAGRDIFAQRSQVTNYLGIEWMRRHLAPDYRVHIISFKDPN
PMHIDATFNIIGPGIVLSNPDRPCHQIDLFKKAGWTIITPPTPIIPDDHPLWMSSKWLSM
NVLMLDEKRVMVDANEVPIQKMFEKLGITTIKVNIRNANSLGGGFHCWTCDVRRRGTLQS
YLD

# Metabolic_Enzyme_6_Number_of_Residues:
423

# Metabolic_Enzyme_6_Molecular_Weight:
48456

# Metabolic_Enzyme_6_Theoretical_pI:
8.15

# Metabolic_Enzyme_6_GO_Classification:
Not Available

# Metabolic_Enzyme_6_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
L-arginine + glycine = L-ornithine + guanidinoacetate

# Metabolic_Enzyme_6_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_6_Reaction:
L-arginine + glycine = L-ornithine + guanidinoacetate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF02274:Amidinotransf

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.1.4.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
545385

# Metabolic_Enzyme_6_SwissProt_ID:
GATM_HUMAN (P50440)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
GATM

# Metabolic_Enzyme_6_Geneatlas_id:
GATM

# Metabolic_Enzyme_6_hgnc_id:
HGNC:4175

# Metabolic_Enzyme_6_PDB_ID:
3JDW

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane; intermembrane side (Potential). Cytoplasm. Note=The mitochondrial form is found in the intermembrane space probably attached to the outer side of the inner membrane

# Metabolic_Enzyme_6_Gene_Sequence:
>1272 bp
ATGCTGCGGGTGCGGTGTCTGCGCGGCGGGAGCCGCGGCGCCGAGGCGGTGCACTACATC
GGATCTCGGCTTGGACGAACCTTGACAGGATGGGTGCAGCGAACTTTCCAGAGCACCCAG
GCAGCTACGGCTTCCTCCCGGAACTCCTGTGCAGCTGACGACAAAGCCACTGAGCCTCTG
CCCAAGGACTGCCCTGTCTCTTCTTACAACGAATGGGACCCCTTAGAGGAAGTGATAGTG
GGCAGAGCAGAAAACGCCTGTGTTCCACCGTTCACCATCGAGGTGAAGGCCAACACATAT
GAAAAGTACTGGCCATTTTACCAGAAGCAAGGAGGGCATTATTTTCCCAAAGATCATTTG
AAAAAGGCTGTTGCTGAAATTGAAGAAATGTGCAATATTTTAAAAACGGAAGGAGTGACA
GTAAGGAGGCCTGACCCCATTGACTGGTCATTGAAGTATAAAACTCCTGATTTTGAGTCT
ACGGGTTTATACAGTGCAATGCCTCGAGACATCCTGATAGTTGTGGGCAATGAGATTATC
GAGGCTCCCATGGCATGGCGTTCACGCTTCTTTGAGTACCGAGCGTACAGGTCAATTATC
AAAGACTACTTCCACCGTGGCGCCAAGTGGACAACAGCTCCTAAGCCCACAATGGCTGAT
GAGCTTTATAACCAGGATTATCCCATCCACTCTGTAGAAGACAGACACAAATTGGCTGCT
CAGGGAAAATTTGTGACAACTGAGTTTGAGCCATGCTTTGATGCTGCTGACTTCATTCGA
GCTGGAAGAGATATTTTTGCACAGAGAAGCCAGGTTACAAACTACCTAGGCATTGAATGG
ATGCGTAGGCATCTTGCTCCAGACTACAGAGTGCATATCATCTCCTTTAAAGATCCCAAT
CCCATGCATATTGATGCTACCTTCAACATCATTGGACCTGGTATTGTGCTTTCCAACCCT
GACCGACCATGTCACCAGATTGATCTTTTCAAGAAAGCAGGATGGACTATCATTACTCCT
CCAACACCAATCATCCCAGACGATCATCCACTCTGGATGTCATCCAAATGGCTTTCCATG
AATGTCTTAATGCTAGATGAAAAACGTGTTATGGTGGATGCCAATGAAGTTCCAATTCAA
AAGATGTTTGAAAAGCTGGGTATCACTACCATTAAAGTTAACATTCGTAATGCCAATTCC
CTGGGAGGAGGCTTCCATTGCTGGACCTGCGATGTCCGGCGCCGAGGCACCCTACAGTCC
TACTTGGACTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
S68805

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_6_Locus:
15q21.1

# Metabolic_Enzyme_6_SNPs:
rs1288775; rs1145086; rs3210028; rs1145080; rs1145077; rs1145081; rs1049508; rs4775937; rs1049518; rs12441971; rs8024550; rs7164602; rs1145079; rs11070454; rs1049503; rs1145084; rs1145078; rs1346268; rs17618637; rs12442696; rs16942568; rs12442078; rs16942588; rs1554521; rs2486274; rs3759899; rs1145085; rs12437887; rs1153854; rs1153855; rs12594857; rs12437840; rs2433611; rs10519022; rs9972498; rs2172874; rs7494956; rs1055395; rs17535381; rs1890565; rs1153857; rs8040380; rs12595087; rs2114501; rs17618783; rs1153856; rs1145076; rs1153858; rs1145089; rs4271549; rs4395020; rs4627277; rs4774579; rs4625670; rs8038342; rs4534782; rs12439575; rs4774580; rs9788780; rs16942663; rs34991226; rs1049491; rs3210030; rs3210027; rs3210026; rs3210029; rs3210025; rs16942529; rs1145083; rs11070455; rs9672959; rs12439919; rs35353298; rs1145082; rs36091209; rs2486273; rs1145087; rs28395435; rs1691665; rs11853955; rs34835251; rs16942536; rs2486272; rs28609657; rs34215740; rs35805543; rs34690026; rs2467850; rs7164139; rs34122808; rs11275645; rs2467851; rs1049511; rs35410548; rs1593621; rs34755569; rs1049502; rs11281225; rs34245967; rs1153853; rs6145546; rs28711439; rs2453543; rs36108646; rs9806260; rs2453542; rs12324848; rs35634173; rs34202663; rs35160985; rs12595153; rs5812296; rs35727417; rs11283178; rs9972528; rs2486275; rs9972405; rs3047502; rs5812295; rs35698201; rs28681101; rs28552543; rs3047503; rs34418487; rs34271244; rs11310088; rs34401164; rs10152697; rs10444821; rs11070453; rs11070456; rs11070457; rs1145090; rs1145091; rs1145093; rs1145094; rs1153851; rs1153859; rs1346267; rs1426932; rs2056493; rs2056494; rs2066090; rs2217121; rs2433604; rs2433608; rs2433609; rs2433610; rs2461702; rs2461704; rs2467862; rs2486271; rs4774577; rs4775911; rs7163751; rs7174251; rs8032904

# Metabolic_Enzyme_6_General_References:
8313955; 9148748; 9165070; 9218780; 9915841

# Metabolic_Enzyme_6_References:
1378964; 15107411; 1511066

# Macromolecular_Interacting_Partner_1_ID:
7803

# Macromolecular_Interacting_Partner_1_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_1_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_1_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_1_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_1_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_1_References:
12781785; 15245754; 16642411; 16773469

End of HMDB00128

Beginning of HMDB00130
# Accession_No:
HMDB00130

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-10 14:56:08

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Homogentisic acid

# Description:
An intermediate of the metabolic breakdown of tyrosine and phenylalanine; it occurs in the urine in cases of alkaptonuria. (OMIN 203500)
Homogentisic acid is the primary precursor of melanin synthesis in Vibrio cholerae. 

# Synonyms:
(2,5-dihydroxyphenyl)-Acetate; (2,5-dihydroxyphenyl)-Acetic acid; 2,5-Dihydroxy-a-toluate; 2,5-Dihydroxy-a-toluic acid; 2,5-Dihydroxy-alpha-toluate; 2,5-Dihydroxy-alpha-toluic acid; 2,5-Dihydroxy-benzeneacetate; 2,5-Dihydroxy-benzeneacetic acid; 2,5-Dihydroxyphenylacetate; 2,5-Dihydroxyphenylacetic acid; Alcapton; Homogentisate; Homogentisate acid; Homogentisinate; Homogentisinic acid;Melanic acid.

# Chemical_IUPAC_Name:
2-(2,5-dihydroxyphenyl)acetic acid

# Chemical_Formula:
C8H8O4

# Chemical_Structure:
tbl_chemical:::HMDB00130_ZOOM.png:::119283207307399987

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00130_THUMB.png:::119283207143275230

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Phenols; Aromatic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
phenol or hydroxyhetarene; carboxylic acid; aromatic compound

# Taxonomy_Biofunction:
Component of Phenylalanine metabolism; Component of Tyrosine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
168.04227

# Molecular_Weight_Avg:
168.14673

# Smiles_String_isomeric:
OC(=O)CC1=C(O)C=CC(O)=C1

# Smiles_String_canonical:
OC(=O)CC1=C(O)C=CC(O)=C1

# KEGG_Compound_ID:
C00544

# BioCyc_ID:
Not Available

# PubChem_CID:
780

# PubChem_SID:
2799; 3137141; 8145847; 153174; 4463070; 8001507; 7889580; 10398312; 3727026; 10553826; 819317; 598682; 8150786; 3825; 7989715; 396365

# OMIM_ID:
203500

# Metagene_ID:
ALKAPTONURIA. HOMOGENTISIC ACID OXIDASE DEFICIENCY: 53

# BiGG_ID:
1485308

# Wikipedia_ID:
Homogentisic acid

# METLIN_ID:
331

# Ref_ID:
12501223; 9529368; 9214216; 15849984; 8925087; 2026685; 8188241; 9870204; 8000039; 1495952; 2383921

# ChEBI_ID:
5755

# CAS_Registry_Number:
451-13-8

# InChI:
InChI=1/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)

# Synthesis_Reference:
Not Available

# Melting_Point:
153 oC

# Melting_Point_predicted:
108.6 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
850 mg/mL at 25 oC [BEILSTEIN]

# H2O_Solubility_Predicted:
8.1 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
0.86 [SANGSTER (1994)]

# LogP_predicted:
0.81 [Predicted by ALOGPS]; 0.887 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00544.mol:::1132723808781735815

# SDF_File_[Text]:
tbl_chemical:::HMDB00130.sdf:::119283206817131069

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00130.pdb:::119283207004873222

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050110_P00_04_IS .png:::117104150818699979

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050110_P00_04_IS .zip:::117104150836852316

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::Homogentisic acid (HMDB00130).png:::117382022054294412

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Homogentisic_acid.gif:::115316690670644522

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00130_peaks.txt:::1156309564809315260

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Homogentisic_acid_C.gif:::115316690673319738

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00130_peaks.txt:::1156310754812589744

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000200.png:::116907444690618428

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000200.txt:::116907444690647205

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000200.png:::11689083113289621

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000200.txt:::11689083115627829

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Cartilage; Connective Tissue; Kidney

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	0.105 (0.04 - 0.17)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	2026685
Blood	0.026 (0.009 - 0.044)	uM	Adult:>18_yrs_old	Both	Normal	8925087


# Concentration_[Abnormal]:
Urine	1819 (1134 - 2504)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Alkaptonuria	12501223
Urine	> 2780	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Alkaptonuria	9529368
Blood	35.5 (33.0 - 38.0)	uM	Adult:>18_yrs_old	Both	Alkaptonuria	2383921


# Associated_Disorders:
Alkaptonuria; Alkaptonuria or Homogentisic Acid Oxidase Deficiency; Tyrosinemia

# Pathway_Names:
Pentose and glucuronate interconversions;Starch and sucrose metabolism;Porphyrin and chlorophyll metabolism;Inositol phosphate metabolism

# Pathway_Images:
;;;

# KEGG_Images:
map00040;map00500;map00860;map00562

# Pathway_Graphs:
;;;

# Pathway_SBMLs:
;;;

# Metabolic_Enzyme_1_ID:
6120

# Metabolic_Enzyme_1_Name:
Beta-glucuronidase precursor

# Metabolic_Enzyme_1_Synonyms:
Beta-G1

# Metabolic_Enzyme_1_Gene_Name:
GUSB

# Metabolic_Enzyme_1_Protein_Sequence:
>Betaglucuronidase precursor
MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFE
EQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVV
LRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTT
LPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQD
SGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYL
YSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKG
FDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNN
VSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVT
FVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSE
YGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTR
VLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSLFT

# Metabolic_Enzyme_1_Number_of_Residues:
651

# Metabolic_Enzyme_1_Molecular_Weight:
74733

# Metabolic_Enzyme_1_Theoretical_pI:
7.02

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Plays an important role in the degradation of dermatan and keratan sulfates

# Metabolic_Enzyme_1_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00500  Starch and sucrose metabolism;
 map00531  Glycosaminoglycan degradation;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_1_Reaction:
a beta-D-glucuronoside + H2O = D-glucuronate + an alcohol

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00703:Glyco_hydro_2;
PF02836:Glyco_hydro_2_C;
PF02837:Glyco_hydro_2_N

# Metabolic_Enzyme_1_Signals:
1-22

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.2.1.31

# Metabolic_Enzyme_1_GenBank_ID_Protein:
183233

# Metabolic_Enzyme_1_SwissProt_ID:
BGLR_HUMAN (P08236)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
GUSB

# Metabolic_Enzyme_1_Geneatlas_id:
GUSB

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4696

# Metabolic_Enzyme_1_PDB_ID:
1BHG

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_1_Gene_Sequence:
>1956 bp
ATGGCCCGGGGGTCGGCGGTTGCCTGGGCGGCGCTCGGGCCGTTGTTGTGGGGCTGCGCG
CTGGGGCTGCAGGGCGGGATGCTGTACCCCCAGGAGAGCCCGTCGCGGGAGTGCAAGGAG
CTGGACGGCCTCTGGAGCTTCCGCGCCGACTTCTCTGACAACCGACGCCGGGGCTTCGAG
GAGCAGTGGTACCGGCGGCCGCTGTGGGAGTCAGGCCCCACCGTGGACATGCCAGTTCCC
TCCAGCTTCAATGACATCAGCCAGGACTGGCGTCTGCGGCATTTTGTCGGCTGGGTGTGG
TACGAACGGGAGGTGATCCTGCCGGAGCGATGGACCCAGGACCTGCGCACAAGAGTGGTG
CTGAGGATTGGCAGTGCCCATTCCTATGCCATCGTGTGGGTGAATGGGGTCGACACGCTA
GAGCATGAGGGGGGCTACCTCCCCTTCGAGGCCGACATCAGCAACCTGGTCCAGGTGGGG
CCCCTGCCCTCCCGGCTCCGAATCACTATCGCCATCAACAACACACTCACCCCCACCACC
CTGCCACCAGGGACCATCCAATACCTGACTGACACCTCCAAGTATCCCAAGGGTTACTTT
GTCCAGAACACATATTTTGACTTTTTCAACTACGCTGGACTGCAGCGGTCTGTACTTCTG
TACACGACACCCACCACCTACATCGATGACATCACCGTCACCACCAGCGTGGAGCAAGAC
AGTGGGCTGGTGAATTACCAGATCTCTGTCAAGGGCAGTAACCTGTTCAAGTTGGAAGTG
CGTCTTTTGGATGCAGAAAACAAAGTCGTGGCGAATGGGACTGGGACCCAGGGCCAACTT
AAGGTGCCAGGTGTCAGCCTCTGGTGGCCGTACCTGATGCACGAACGCCCTGCCTATCTG
TATTCATTGGAGGTGCAGCTGACTGCACAGACGTCACTGGGGCCTGTGTCTGACTTCTAC
ACACTCCCTGTGGGGATCCGCACTGTGGCTGTCACCAAGAGCCAGTTCCTCATCAATGGG
AAACCTTTCTATTTCCACGGTGTCAACAAGCATGAGGATGCGGACATCCGAGGGAAGGGC
TTCGACTGGCCGCTGCTGGTGAAGGACTTCAACCTGCTTCGCTGGCTTGGTGCCAACGCT
TTCCGTACCAGCCACTACCCCTATGCAGAGGAAGTGATGCAGATGTGTGACCGCTATGGG
ATTGTGGTCATCGATGAGTGTCCCGGCGTGGGCCTGGCGCTGCCGCAGTTCTTCAACAAC
GTTTCTCTGCATCACCACATGCAGGTGATGGAAGAAGTGGTGCGTAGGGACAAGAACCAC
CCCGCGGTCGTGATGTGGTCTGTGGCCAACGAGCCTGCGTCCCACCTAGAATCTGCTGGC
TACTACTTGAAGATGGTGATCGCTCACACCAAATCCTTGGACCCCTCCCGGCCTGTGACC
TTTGTGAGCAACTCTAACTATGCAGCAGACAAGGGGGCTCCGTATGTGGATGTGATCTGT
TTGAACAGCTACTACTCTTGGTATCACGACTACGGGCACCTGGAGTTGATTCAGCTGCAG
CTGGCCACCCAGTTTGAGAACTGGTATAAGAAGTATCAGAAGCCCATTATTCAGAGCGAG
TATGGAGCAGAAACGATTGCAGGGTTTCACCAGGATCCACCTCTGATGTTCACTGAAGAG
TACCAGAAAAGTCTGCTAGAGCAGTACCATCTGGGTCTGGATCAAAAACGCAGAAAATAT
GTGGTTGGAGAGCTCATTTGGAATTTTGCCGATTTCATGACTGAACAGTCACCGACGAGA
GTGCTGGGGAATAAAAAGGGGATCTTCACTCGGCAGAGACAACCAAAAAGTGCAGCGTTC
CTTTTGCGAGAGAGATACTGGAAGATTGCCAATGAAACCAGGTATCCCCACTCAGTAGCC
AAGTCACAATGTTTGGAAAACAGCCCGTTTACTTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M15182

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_1_Locus:
7q21.11

# Metabolic_Enzyme_1_SNPs:
rs9530; rs1061361; rs2279903; rs2008188; rs781144; rs4718296; rs1880555; rs781143; rs1880556; rs12535204; rs4717280; rs6460266; rs17138062; rs12540589; rs12670952; rs781146; rs906134; rs1185223; rs10279841; rs781145; rs6955582; rs13245858; rs7800210; rs13228566; rs736270; rs7803283; rs7383796; rs12698510; rs34994057; rs781141; rs2279904; rs2961102; rs10245248; rs11559283; rs35302712; rs11559281; rs1723276; rs34983797; rs28669341; rs2949698; rs34970380; rs3105600; rs34277954; rs1701764; rs35248213; rs35244943; rs781142; rs6954920; rs35434779; rs35820085; rs34345393; rs10273958; rs11287621; rs10246998; rs2293340; rs3830444; rs4451200; rs28460798; rs7801713; rs34282416; rs937108; rs3061581; rs35197523; rs1626926; rs34611218; rs28667742; rs7786674; rs35542501; rs10229667; rs28628473; rs10238732; rs28418543; rs11355040; rs34606859; rs13226598; rs34275777; rs34025127; rs10274777; rs35957142; rs10807697; rs12538430; rs12698509; rs13230304; rs3735143; rs3735144; rs4504525; rs709607

# Metabolic_Enzyme_1_General_References:
3468507; 12853948; 1916806; 1311180; 3924735; 12754519; 8599764; 8111412; 8111413; 1702266; 7680524

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6121

# Metabolic_Enzyme_2_Name:
Inositol oxygenase

# Metabolic_Enzyme_2_Synonyms:
Myo-inositol oxygenase; Aldehyde reductase-like 6; Renal-specific oxidoreductase; Kidney-specific protein 32

# Metabolic_Enzyme_2_Gene_Name:
MIOX

# Metabolic_Enzyme_2_Protein_Sequence:
>Inositol oxygenase
MKVTVGPDPSLVYRPDVDPEVAKDKASFRNYTSGPLLDRVFTTYKLMHTHQTVDFVRSKH
AQFGGFSYKKMTVMEAVDLLDGLVDESDPDVDFPNSFHAFQTAEGIRKAHPDKDWFHLVG
LLHDLGKVLALFGEPQWAVVGDTFPVGCRPQASVVFCDSTFQDNPDLQDPRYSTELGMYQ
PHCGLDRVLMSWGHDEYMYQVMKFNKFSLPPEAFYMIRFHSFYPWHTGRDYQQLCSQQDL
AMLPWVREFNKFDLYTKCPDLPDVDKLRPYYQGLIDKYCPGILSW

# Metabolic_Enzyme_2_Number_of_Residues:
285

# Metabolic_Enzyme_2_Molecular_Weight:
33010

# Metabolic_Enzyme_2_Theoretical_pI:
5.74

# Metabolic_Enzyme_2_GO_Classification:
Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Myo-inositol + O(2) = D-glucuronate + H(2)O

# Metabolic_Enzyme_2_Pathway:
map00562  Inositol phosphate metabolism

# Metabolic_Enzyme_2_Reaction:
myo-inositol + O2 = D-glucuronate + H2O

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF05153:DUF706

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.13.99.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
17932582

# Metabolic_Enzyme_2_SwissProt_ID:
MIOX_HUMAN (Q9UGB7)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
MIOX

# Metabolic_Enzyme_2_Geneatlas_id:
MIOX

# Metabolic_Enzyme_2_hgnc_id:
HGNC:14522

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>858 bp
ATGAAGGTGACGGTGGGCCCAGACCCTTCCCTGGTCTACCGACCTGATGTGGACCCAGAG
GTGGCCAAAGACAAGGCCAGCTTCCGGAACTACACGTCAGGTCCCCTCCTGGACCGTGTC
TTCACCACCTACAAGCTCATGCACACGCACCAGACAGTGGACTTCGTCAGGAGCAAGCAT
GCCCAGTTTGGGGGCTTCTCCTACAAGAAAATGACAGTCATGGAGGCCGTGGACCTGCTG
GATGGGCTGGTGGATGAGTCGGACCCGGACGTAGATTTCCCCAACTCCTTCCATGCCTTC
CAGACAGCGGAGGGCATCCGGAAGGCCCACCCAGACAAGGACTGGTTCCACCTCGTCGGG
CTCCTGCACGACCTGGGGAAGGTCCTGGCCCTGTTCGGGGAGCCCCAGTGGGCTGTCGTC
GGCGACACCTTCCCCGTCGGATGCCGTCCGCAGGCCTCCGTGGTTTTCTGCGACTCCACC
TTCCAGGACAACCCTGACCTCCAGGATCCTCGATACAGCACAGAGCTCGGGATGTATCAG
CCCCACTGTGGGCTCGACAGGGTCCTCATGTCCTGGGGCCATGATGAGTACATGTACCAG
GTGATGAAGTTTAACAAGTTCTCACTGCCCCCTGAGGCTTTCTACATGATCCGGTTCCAC
TCCTTCTACCCCTGGCACACGGGCCGCGACTACCAGCAGCTGTGCAGCCAGCAGGACCTG
GCCATGCTGCCCTGGGTGCGGGAGTTCAACAAGTTCGACCTCTACACCAAGTGCCCGGAC
CTGCCGGACGTGGACAAGCTGCGGCCCTACTACCAGGGGCTCATTGACAAGTACTGCCCT
GGCATCCTGAGCTGGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AY064416

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_2_Locus:
22q13.3

# Metabolic_Enzyme_2_SNPs:
rs2232885; rs2232883; rs1055271; rs1064043; rs2232876; rs3747273; rs8140944; rs12484236; rs8138644; rs8136151; rs8136078; rs8140686; rs41280567; rs2232882; rs11556222; rs2232884; rs2232886; rs2232888; rs2232887; rs34472885; rs1055272; rs11705385; rs11705365; rs2232889; rs35968105; rs8142721; rs28478317; rs34136024; rs35664871; rs2232877; rs36033733; rs12484911; rs3747272; rs13056168; rs2232881; rs2232878; rs2232879; rs28433386; rs10538866; rs41280565; rs2232880; rs2232875; rs34404629; rs1138428; rs13053471; rs13055726; rs13056677; rs134975; rs2232871; rs2232872; rs2232873; rs2232874; rs2236031; rs2236032; rs2334100; rs34589122; rs35576574; rs4824156; rs4824157; rs6009971; rs6009974; rs6010108; rs761745; rs8138406; rs8141795; rs8141931; rs876278; rs9616854

# Metabolic_Enzyme_2_General_References:
10944187; 10591208

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6122

# Metabolic_Enzyme_3_Name:
4-hydroxyphenylpyruvate dioxygenase

# Metabolic_Enzyme_3_Synonyms:
4HPPD; HPD; HPPDase; 4-hydroxyphenylpyruvic acid oxidase

# Metabolic_Enzyme_3_Gene_Name:
HPD

# Metabolic_Enzyme_3_Protein_Sequence:
>4hydroxyphenylpyruvate dioxygenase
MTTYSDKGAKPERGRFLHFHSVTFWVGNAKQAASFYCSKMGFEPLAYRGLETGSREVVSH
VIKQGKIVFV
LSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAKIMR
EPWVEQDKFGKVKFAVLQTYG
DTTHTLVEKMNYIGQFLPGYEAPAFMDPLLPKLPKCSL
EMIDHIVGNQPDQEMVSASEWYLKNLQFHRFW
SVDDTQVHTEYSSLRSIVVANYEESIK
MPINEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRH
LRERGLEFLSVPSTYY
KQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIFTKPVQDRPTLFLEV
IQRHN
HQGFGAGNFNSLFKAFEEEQNLRGNLTNMETNGVVPGM

# Metabolic_Enzyme_3_Number_of_Residues:
393

# Metabolic_Enzyme_3_Molecular_Weight:
44935

# Metabolic_Enzyme_3_Theoretical_pI:
7.01

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
Function:  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Function:  4-hydroxyphenylpyruvate dioxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
4-hydroxyphenylpyruvate + O(2) = homogentisate + CO(2)

# Metabolic_Enzyme_3_Pathway:
map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_3_Reaction:
4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00903:Glyoxalase

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.13.11.27

# Metabolic_Enzyme_3_GenBank_ID_Protein:
3860238

# Metabolic_Enzyme_3_SwissProt_ID:
HPPD_HUMAN (P32754)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
HPD

# Metabolic_Enzyme_3_Geneatlas_id:
HPD

# Metabolic_Enzyme_3_hgnc_id:
HGNC:5147

# Metabolic_Enzyme_3_PDB_ID:
1SQI

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>1182 bp

ATGACGACTTACAGTGACAAAGGGGCAAAGCCTGAGAGAGGCCGATTCCTCCACTTCCA
CTCTGTGACCT
TCTGGGTTGGCAACGCCAAGCAGGCCGCGTCATTCTACTGCAGCAAGA
TGGGCTTTGAACCTCTAGCCTA
CAGGGGCCTGGAGACCGGTTCCCGGGAGGTGGTCAGC
CATGTAATCAAACAAGGGAAGATTGTGTTTGTC
CTCTCCTCAGCGCTCAACCCCTGGAA
CAAAGAGATGGGCGATCACCTGGTGAAACACGGTGACGGAGTGA
AGGACATTGCGTTCG
AGGTGGAAGATTGTGACTACATCGTGCAGAAAGCACGGGAACGGGGCGCCAAAAT
CATG
CGGGAGCCCTGGGTAGAGCAAGACAAGTTTGGGAAGGTGAAGTTTGCTGTGCTGCAGACG
TATGGG
GACACCACACACACCCTGGTGGAGAAGATGAACTACATCGGCCAATTCTTGCC
TGGATATGAGCCCCCAG
CGTTCATGGACCCCCTACTTCCTAAACTGCCCAAATGCAGTC
TGGAGATGATCGACCACATTGTGGGAAA
CCAGCCTGATCAGGAGATGGTGTCCGCCTCC
GAATGGTACCTGAAAAACCTGCAGTTCCACCGCTTCTGG
TCCGTGGATGACACGCAGGT
GCACACGGAATATAGCTCTCTGCGATCCATTGTGGTGGCCAACTATGAAG
AGTCCATCA
AGATGCCCATCAATGAGCCAGCGCCTGGCAAGAAGAAGTCCCAGATCCAGGAATATGTGG
A
CTATAACGGGGGCGCTGGGGTCCAGCACATCGCTCTCAAGACCGAAGACATCATCACA
GCGATTCGCCAC
TTGAGAGAGAGAGGCCTGGAGTTCTTATCTGTTCCCTCCACGTACTA
CAAACAACTGCGGGAGAAGCTGA
AGACGGCCAAGATCAAGGTGAAGGAGAACATTGATG
CCCTGGAGGAGCTGAAAATCCTGGTGGACTACGA
CGAGAAAGGCTACCTCCTGCAGATC
TTCACCAAACCGGTGCAGGACCGGCCCACGCTCTTCCTGGAAGTC
ATCCAGCGCCACAA
CCACCAGGGTTTTGGAGCCGGCAACTTCAACTCACTGTTCAAGGCTTTCGAGGAGG
AGC
AGAACCTGCGGGGTAACCTCACCAACATGGAGACCAATGGGGTGGTGCCCGGCATGTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U29895

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_3_Locus:
12q24-qter

# Metabolic_Enzyme_3_SNPs:
rs1154510; rs11833399; rs36023382; rs2247291; rs1449562; rs2596140; rs1610041; rs2515729; rs1795963; rs4760102; rs3741587; rs2620334; rs2707072; rs3741586; rs2707056; rs10840622; rs11043214; rs2707070; rs12310752; rs2620340; rs2707055; rs2707075; rs10840623; rs3832816; rs2707058; rs4760103; rs11043217; rs11043213; rs11613865; rs11043216; rs2620339; rs2620332; rs4760105; rs1154515; rs2596144; rs2596143; rs4298948; rs3741591; rs11043218; rs10840619; rs2596142; rs35115987; rs2596139; rs35849100; rs1801436; rs1126925; rs1042843; rs1042844; rs2707063; rs2620354; rs2620333; rs12830647; rs1154512; rs2707074; rs2855415; rs35794561; rs35616764; rs2442440; rs4516009; rs2515730; rs2620350; rs12580755; rs12372468; rs2596145; rs2620337; rs12313193; rs28711529; rs1154516; rs1154511; rs4439557; rs35705173; rs11043212; rs1894285; rs2596141; rs2707054; rs35476559; rs35131803; rs2620347; rs2620349; rs12820413; rs35384269; rs2707071; rs35232597; rs2620338; rs35599566; rs34943778; rs11043211; rs35849071; rs12830638; rs35556469; rs12821095; rs9668731; rs2515731; rs2620335; rs2620346; rs35712089; rs2859577; rs2620348; rs2596138; rs35593190; rs1183890; rs12825630; rs12826129; rs10600651; rs11043210; rs12299502; rs2442441; rs2855414; rs2448483; rs11043215; rs2620336; rs35633723; rs2620341; rs34879391; rs3970383; rs2707057; rs2596146; rs2707073; rs2707062; rs34360786; rs35870123; rs34073901; rs11043219; rs35359220; rs34777671; rs11395265; rs35918033; rs12822028; rs33973864; rs5801455; rs36096665; rs34042138; rs10840624; rs11043207; rs11043222; rs11043223; rs11614326; rs12316702; rs12823194; rs9668191

# Metabolic_Enzyme_3_General_References:
8504803; 7851880; 8521727; 10942115; 11073718

# Metabolic_Enzyme_3_References:
10665936; 11243724; 15084729; 8071207

# Metabolic_Enzyme_4_ID:
8775

# Metabolic_Enzyme_4_Name:
HGD protein

# Metabolic_Enzyme_4_Synonyms:
Not Available

# Metabolic_Enzyme_4_Gene_Name:
Not Available

# Metabolic_Enzyme_4_Protein_Sequence:
>HGD protein
MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW
LYRILPSVSHKPFESIDEGHVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC
GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC
VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP
GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV
LTALRRPARSSWHLRGLPMAPWHLCLNHL

# Metabolic_Enzyme_4_Number_of_Residues:
329

# Metabolic_Enzyme_4_Molecular_Weight:
37263

# Metabolic_Enzyme_4_Theoretical_pI:
6.89

# Metabolic_Enzyme_4_GO_Classification:
>>>
 Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
Function:  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Function:  homogentisate 1,2-dioxygenase activity
 ||
>>>
 Process:  tyrosine metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
Process:  L-phenylalanine metabolism
Process:  L-phenylalanine catabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_4_Specific_Function:
Homogentisate + O(2) = 4-maleylacetoacetate

# Metabolic_Enzyme_4_Pathway:
Not Available

# Metabolic_Enzyme_4_Reaction:
Not Available

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF04209:HgmA

# Metabolic_Enzyme_4_Signals:
Not Available

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.13.11.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
18088530

# Metabolic_Enzyme_4_SwissProt_ID:
Q8WW71_HUMAN (Q8WW71)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
HGD

# Metabolic_Enzyme_4_Geneatlas_id:
HGD

# Metabolic_Enzyme_4_hgnc_id:
HGNC:4892

# Metabolic_Enzyme_4_PDB_ID:
1EYB

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>990 bp
ATGGCTGAGTTAAAGTACATTTCTGGATTTGGGAATGAGTGTTCTTCAGAGGATCCTCGC
TGCCCAGGTTCCCTGCCAGAAGGACAGAATAATCCTCAGGTCTGCCCCTACAATCTCTAT
GCTGAGCAGCTCTCAGGATCGGCTTTCACTTGTCCACGGAGCACCAATAAGAGAAGCTGG
CTGTATAGGATTCTACCTTCAGTTTCTCACAAGCCCTTTGAATCCATTGACGAAGGCCAT
GTCACTCACAACTGGGATGAAGTTGATCCTGATCCTAACCAGCTTAGATGGAAACCATTT
GAGATTCCAAAAGCATCTCAGAAGAAAGTAGACTTTGTGAGTGGCCTGCATACCTTGTGT
GGAGCTGGAGACATAAAGTCTAACAATGGGCTTGCTATCCACATTTTCCTCTGCAATACC
TCCATGGAGAACAGATGCTTTTACAATTCAGATGGGGACTTCTTGATTGTTCCGCAGAAA
GGGAACCTTCTCATTTACACCGAGTTTGGCAAGATGCTTGTACAGCCCAATGAGATCTGC
GTCATTCAGAGAGGAATGCGGTTCAGCATAGATGTCTTTGAGGAGACCAGGGGCTACATC
TTGGAGGTCTATGGTGTCCACTTTGAGTTACCTGACCTTGGACCAATTGGGGCCAATGGC
TTGGCCAATCCTCGTGATTTCTTGATACCCATTGCCTGGTATGAGGATCGCCAAGTACCA
GGTGGTTACACGGTCATTAATAAATACCAGGGCAAGCTGTTTGCTGCCAAACAGGATGTC
TCCCCGTTCAATGTTGTGGCCTGGCACGGGAATTATACACCCTACAAGTACAACCTGAAG
AATTTCATGGTTATCAACTCAGTGGCCTTTGACCATGCAGACCCATCCATTTTCACAGTA
TTGACTGCTTTGAGAAGGCCAGCAAGGTCAAGCTGGCACCTGAGAGGATTGCCGATGGCA
CCATGGCATTTATGTTTGAATCATCTTTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
BC020792

# Metabolic_Enzyme_4_Chromosome_Location:
Not Available

# Metabolic_Enzyme_4_Locus:
Not Available

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
12477932

# Metabolic_Enzyme_4_References:
Not Available

End of HMDB00130

Beginning of HMDB00131
# Accession_No:
HMDB00131

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-23 12:25:16

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Glycerol

# Description:
Glycerol is an important component of triglycerides (i.e. fats and oils) and of phospholipids. Glycerol is a three-carbon substance that forms the backbone of fatty acids in fats. When the body uses stored fat as a source of energy, glycerol and fatty acids are released into the bloodstream. The glycerol component can be converted to glucose by the liver and provides energy for cellular metabolism.

# Synonyms:
1,2,3-Trihydroxypropane; Bulbold; Cristal; E 422; Emery 916; Glyceol Opthalgan; Glycerin; Glycerine; Glyceritol; Glycerol; Glycyl alcohol; Glyrol; Glysanin; IFP; Incorporation factor; Mackstat H 66; Osmoglyn; Pricerine 9091; Propanetriol; RG-S; Trihydroxypropane; Tryhydroxypropane

# Chemical_IUPAC_Name:
1,2,3-Propanetriol

# Chemical_Formula:
C3H8O3

# Chemical_Structure:
tbl_chemical:::HMDB00131_ZOOM.png:::119283208136559223

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00131_THUMB.png:::119283207998860167

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Glycerols

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary alcohol; secondary alcohol; 1,2-diol

# Taxonomy_Biofunction:
Component of Glycerolipid metabolism; Component of Glycerophospholipid metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
92.04735

# Molecular_Weight_Avg:
92.09382

# Smiles_String_isomeric:
OCC(O)CO

# Smiles_String_canonical:
OCC(O)CO

# KEGG_Compound_ID:
C00116

# BioCyc_ID:
GLYCEROL

# PubChem_CID:
753

# PubChem_SID:
11532003; 11538328; 11538610; 11538617; 11538569; 11532348; 11532533; 11538177; 11110518; 11532364; 11532853; 11538573; 11538189; 11532350; 11538929; 11532822; 11532593; 11538720; 11532035; 11539012; 11538908; 11539085; 11538567; 11538923; 11532578; 11532619; 11532340; 11539068; 11532754; 11538925; 11532352; 11532466; 11531985; 11532356; 11531981; 11539127; 11110502; 11404366; 11532358; 11539137; 11532650; 11532787; 12055630; 11538319; 11538613; 3135983; 11532031; 11532676; 11539087; 11538180; 11532669; 11538615; 11532354; 11532253; 11532028; 11538608; 11532016; 11110486; 148790; 11538526; 11539028; 11538401; 11532362; 11532277; 11532611; 587705; 11532263; 11532248; 11532375; 11538511; 11531989; 11532646; 3885789; 11532704; 11538419; 11532129; 11538183; 11532601; 11538571; 11532780; 11538793; 11539078; 11538931; 11532711; 11532287; 14709299; 11532808; 11538305; 11531940; 11539013; 11528316; 11532109; 11538565; 11532536; 11532806; 11539067; 11532360; 174999; 11538927; 11538200

# OMIM_ID:
139320; 307030; 602914

# Metagene_ID:
FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY: 128; GLYCEROL KINASE DEFICIENCY: 154; ARTEFACTS-PHARMACEUTICAL PRODUCTS, INTERFERENCE IN AMINOACID AND ORGANIC ACID ANALYSIS [DD]: 347

# BiGG_ID:
33915

# Wikipedia_ID:
Glycerol

# METLIN_ID:
105

# Ref_ID:
558160; 12085703; 11302662; 12713573; 14708889; 11994365; 15026783; 16475911; 6299616; 15778861; 7337752; 15618446; 16836692; 12687625; 15983192; 8257730; 12138207; 688619; 15332353; 15939412

# ChEBI_ID:
17754

# CAS_Registry_Number:
56-81-5

# InChI:
InChI=1/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2

# Synthesis_Reference:
Hydroxylation of the double bond.     Milas, Nicholas A.; Sussman, Sidney.    Journal of the American Chemical Society  (1936),  58  1302-4.

# Melting_Point:
20

# Melting_Point_predicted:
26.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1000.0 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
1.17e+03 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Liquid

# LogP:
-1.76 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-1.92 [Predicted by ALOGPS]; -1.9 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00131_MSDS_1.html:::109712806966875>>>tbl_chemical:::HMDB00131_MSDS_2.pdf:::134135841805403

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Glycerol.mol:::1132723808875422115

# SDF_File_[Text]:
tbl_chemical:::HMDB00131.sdf:::119283207700483400

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00131.pdb:::119283207862471103

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::041201_P07_21_BA_1DC_109.jpg:::114176456493489312

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041201_P07_21_BA_1DC_109.zip:::114176460715141588

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041201_P07_21_BA_1DC_109_Assigned.jpg:::11432294490742412

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041201_P07_21_BA_2DHSQC_399.jpg:::114617951521988385

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041201_P07_21_BA_2DHSQC_399.zip:::114617951522776477

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041201_P07_21_BA_2DHSQC_399_Assigned.jpg:::114781505731949264

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Glycerol.gif:::1132732112125529032

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00131_peaks.txt:::1156309565818828786

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Glycerol_C.gif:::1132737693900416566

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00131_peaks.txt:::1156310755823710053

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00131L.png:::117555266712523200; Medium Energy:tbl_ms:::HMDB00131M.png:::117555270677098889; High Energy:tbl_ms:::HMDB00131H.png:::117555272652248078

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000184.png:::116907444493745209

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000184.txt:::116907444493747152

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000184.png:::116890830453148921

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000184.txt:::11689083048908338

# Cellular_Location:
Cytoplasm (Predicted from LogP); Extracellular; mitochondria

# Tissue_Location:
Adipose Tissue; Bladder; Brain; Epidermis; Kidney; Liver; Muscle; Myelin; Nerves; Neurons; Pancreas; Placenta; Skeletal Muscle; Skin; Spleen; Stratum Corneum; Testis; Thyroid Gland

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	17.0 +/- 43.4	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	14708889
Urine	11.5 +/- 138.5	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	14708889
Urine	9.9 +/- 16.8	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	14708889
Urine	5.1 +/- 8.8	umol/mmol_creatinine	Adolescent:13-18_yrs_old	Both	Normal	14708889
Urine	19.6 +/- 34.9	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	14708889
Urine	18.9 +/- 351.8	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	14708889
Urine	11.6 +/- 858	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	14708889
Urine	3.4 +/- 21.6	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	14708889
Urine	6.2 +/- 56.7	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	14708889
Urine	5.7 +/- 9.8	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	14708889
Blood	40.0 +/- 19.0	uM	Newborn:0-30_days_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	43.0 +/-  9.0	uM	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	50.0 +/- 16.0	uM	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	< 280	uM	Adult:>18_yrs_old	N/A	Normal	15026783
Blood	82.0 (27.0-137.0)	uM	Adult:>18_yrs_old	N/A	Normal	688619
Cerebrospinal_Fluid(CSF)	17.5	uM	Adult:>18_yrs_old	Both	Normal	
Cerebrospinal_Fluid(CSF)	13.5 (11.0 - 16.0)	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.


# Concentration_[Abnormal]:
Urine	10525.0(2630.0 - 18420.0)	uM	Adult:>18_yrs_old	N/A	Glycerol Kinase Deficiency	6299616
Blood	2000	uM	Children:1-13_yrs_old	N/A	Glycerol Kinase Deficiency	6299616


# Associated_Disorders:
Glycerol Kinase Deficiency

# Pathway_Names:
Not Available

# Pathway_Images:
Not Available

# KEGG_Images:
Not Available

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5702

# Metabolic_Enzyme_1_Name:
Glycine amidinotransferase, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
L- arginine:glycine amidinotransferase; Transamidinase; AT

# Metabolic_Enzyme_1_Gene_Name:
GATM

# Metabolic_Enzyme_1_Protein_Sequence:
>Glycine amidinotransferase, mitochondrial precursor
MLRVRCLRGGSRGAEAVHYIGSRLGRTLTGWVQRTFQSTQAATASSRNSCAADDKATEPL
PKDCPVSSYNEWDPLEEVIVGRAENACVPPFTIEVKANTYEKYWPFYQKQGGHYFPKDHL
KKAVAEIEEMCNILKTEGVTVRRPDPIDWSLKYKTPDFESTGLYSAMPRDILIVVGNEII
EAPMAWRSRFFEYRAYRSIIKDYFHRGAKWTTAPKPTMADELYNQDYPIHSVEDRHKLAA
QGKFVTTEFEPCFDAADFIRAGRDIFAQRSQVTNYLGIEWMRRHLAPDYRVHIISFKDPN
PMHIDATFNIIGPGIVLSNPDRPCHQIDLFKKAGWTIITPPTPIIPDDHPLWMSSKWLSM
NVLMLDEKRVMVDANEVPIQKMFEKLGITTIKVNIRNANSLGGGFHCWTCDVRRRGTLQS
YLD

# Metabolic_Enzyme_1_Number_of_Residues:
423

# Metabolic_Enzyme_1_Molecular_Weight:
48456

# Metabolic_Enzyme_1_Theoretical_pI:
8.15

# Metabolic_Enzyme_1_GO_Classification:
Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
L-arginine + glycine = L-ornithine + guanidinoacetate

# Metabolic_Enzyme_1_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_1_Reaction:
L-arginine + glycine = L-ornithine + guanidinoacetate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF02274:Amidinotransf

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.1.4.1

# Metabolic_Enzyme_1_GenBank_ID_Protein:
545385

# Metabolic_Enzyme_1_SwissProt_ID:
GATM_HUMAN (P50440)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
GATM

# Metabolic_Enzyme_1_Geneatlas_id:
GATM

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4175

# Metabolic_Enzyme_1_PDB_ID:
3JDW

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane; intermembrane side (Potential). Cytoplasm. Note=The mitochondrial form is found in the intermembrane space probably attached to the outer side of the inner membrane

# Metabolic_Enzyme_1_Gene_Sequence:
>1272 bp
ATGCTGCGGGTGCGGTGTCTGCGCGGCGGGAGCCGCGGCGCCGAGGCGGTGCACTACATC
GGATCTCGGCTTGGACGAACCTTGACAGGATGGGTGCAGCGAACTTTCCAGAGCACCCAG
GCAGCTACGGCTTCCTCCCGGAACTCCTGTGCAGCTGACGACAAAGCCACTGAGCCTCTG
CCCAAGGACTGCCCTGTCTCTTCTTACAACGAATGGGACCCCTTAGAGGAAGTGATAGTG
GGCAGAGCAGAAAACGCCTGTGTTCCACCGTTCACCATCGAGGTGAAGGCCAACACATAT
GAAAAGTACTGGCCATTTTACCAGAAGCAAGGAGGGCATTATTTTCCCAAAGATCATTTG
AAAAAGGCTGTTGCTGAAATTGAAGAAATGTGCAATATTTTAAAAACGGAAGGAGTGACA
GTAAGGAGGCCTGACCCCATTGACTGGTCATTGAAGTATAAAACTCCTGATTTTGAGTCT
ACGGGTTTATACAGTGCAATGCCTCGAGACATCCTGATAGTTGTGGGCAATGAGATTATC
GAGGCTCCCATGGCATGGCGTTCACGCTTCTTTGAGTACCGAGCGTACAGGTCAATTATC
AAAGACTACTTCCACCGTGGCGCCAAGTGGACAACAGCTCCTAAGCCCACAATGGCTGAT
GAGCTTTATAACCAGGATTATCCCATCCACTCTGTAGAAGACAGACACAAATTGGCTGCT
CAGGGAAAATTTGTGACAACTGAGTTTGAGCCATGCTTTGATGCTGCTGACTTCATTCGA
GCTGGAAGAGATATTTTTGCACAGAGAAGCCAGGTTACAAACTACCTAGGCATTGAATGG
ATGCGTAGGCATCTTGCTCCAGACTACAGAGTGCATATCATCTCCTTTAAAGATCCCAAT
CCCATGCATATTGATGCTACCTTCAACATCATTGGACCTGGTATTGTGCTTTCCAACCCT
GACCGACCATGTCACCAGATTGATCTTTTCAAGAAAGCAGGATGGACTATCATTACTCCT
CCAACACCAATCATCCCAGACGATCATCCACTCTGGATGTCATCCAAATGGCTTTCCATG
AATGTCTTAATGCTAGATGAAAAACGTGTTATGGTGGATGCCAATGAAGTTCCAATTCAA
AAGATGTTTGAAAAGCTGGGTATCACTACCATTAAAGTTAACATTCGTAATGCCAATTCC
CTGGGAGGAGGCTTCCATTGCTGGACCTGCGATGTCCGGCGCCGAGGCACCCTACAGTCC
TACTTGGACTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
S68805

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_1_Locus:
15q21.1

# Metabolic_Enzyme_1_SNPs:
rs1288775; rs1145086; rs3210028; rs1145080; rs1145077; rs1145081; rs1049508; rs4775937; rs1049518; rs12441971; rs8024550; rs7164602; rs1145079; rs11070454; rs1049503; rs1145084; rs1145078; rs1346268; rs17618637; rs12442696; rs16942568; rs12442078; rs16942588; rs1554521; rs2486274; rs3759899; rs1145085; rs12437887; rs1153854; rs1153855; rs12594857; rs12437840; rs2433611; rs10519022; rs9972498; rs2172874; rs7494956; rs1055395; rs17535381; rs1890565; rs1153857; rs8040380; rs12595087; rs2114501; rs17618783; rs1153856; rs1145076; rs1153858; rs1145089; rs4271549; rs4395020; rs4627277; rs4774579; rs4625670; rs8038342; rs4534782; rs12439575; rs4774580; rs9788780; rs16942663; rs34991226; rs1049491; rs3210030; rs3210027; rs3210026; rs3210029; rs3210025; rs16942529; rs1145083; rs11070455; rs9672959; rs12439919; rs35353298; rs1145082; rs36091209; rs2486273; rs1145087; rs28395435; rs1691665; rs11853955; rs34835251; rs16942536; rs2486272; rs28609657; rs34215740; rs35805543; rs34690026; rs2467850; rs7164139; rs34122808; rs11275645; rs2467851; rs1049511; rs35410548; rs1593621; rs34755569; rs1049502; rs11281225; rs34245967; rs1153853; rs6145546; rs28711439; rs2453543; rs36108646; rs9806260; rs2453542; rs12324848; rs35634173; rs34202663; rs35160985; rs12595153; rs5812296; rs35727417; rs11283178; rs9972528; rs2486275; rs9972405; rs3047502; rs5812295; rs35698201; rs28681101; rs28552543; rs3047503; rs34418487; rs34271244; rs11310088; rs34401164; rs10152697; rs10444821; rs11070453; rs11070456; rs11070457; rs1145090; rs1145091; rs1145093; rs1145094; rs1153851; rs1153859; rs1346267; rs1426932; rs2056493; rs2056494; rs2066090; rs2217121; rs2433604; rs2433608; rs2433609; rs2433610; rs2461702; rs2461704; rs2467862; rs2486271; rs4774577; rs4775911; rs7163751; rs7174251; rs8032904

# Metabolic_Enzyme_1_General_References:
8313955; 9148748; 9165070; 9218780; 9915841

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5663

# Metabolic_Enzyme_2_Name:
Guanidinoacetate N-methyltransferase

# Metabolic_Enzyme_2_Synonyms:
Not Available

# Metabolic_Enzyme_2_Gene_Name:
GAMT

# Metabolic_Enzyme_2_Protein_Sequence:
>Guanidinoacetate Nmethyltransferase
MSAPSATPIFAPGENCSPAWGAAPAAYDAADTHLRILGKPVMERWETPYMHALAAAASSK
GGRVLEVGFGMAIAASKVQEAPIDEHWIIECNDGVFQRLRDWAPRQTHKVIPLKGLWEDV
APTLPDGHFDGILYDTYPLSEETWHTHQFNFIKNHAFRLLKPGGVLTYCNLTSWGELMKS
KYSDITIMFEETQVPALLEAGFRRENIRTEVMALVPPADCRYYAFPQMITPLVTKG

# Metabolic_Enzyme_2_Number_of_Residues:
236

# Metabolic_Enzyme_2_Molecular_Weight:
26318

# Metabolic_Enzyme_2_Theoretical_pI:
6.09

# Metabolic_Enzyme_2_GO_Classification:
Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine

# Metabolic_Enzyme_2_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_2_Reaction:
S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine

# Metabolic_Enzyme_2_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.1.1.2

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1212946

# Metabolic_Enzyme_2_SwissProt_ID:
GAMT_HUMAN (Q14353)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
GAMT

# Metabolic_Enzyme_2_Geneatlas_id:
GAMT

# Metabolic_Enzyme_2_hgnc_id:
HGNC:4136

# Metabolic_Enzyme_2_PDB_ID:
1XCL

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>711 bp
ATGAGCGCCCCCAGCGCGACCCCCATCTTCGCGCCCGGCGAGAACTGCAGCCCCGCGTGG
GGGGCGGCGCCCGCGGCCTACGACGCAGCGGACACGCACCTGCGCATCCTGGGCAAGCCG
GTGATGGAGCGCTGGGAGACCCCCTATATGCACGCGCTGGCCGCCGCCGCCTCCTCCAAA
GGGGGCCGGGTCCTGGAGGTGGGCTTTGGCATGGCCATCGCAGCGTCAAAGGTGCAGGAG
GCGCCCATTGATGAGCATTGGATCATCGAGTGCAATGACGGCGTCTTCCAGCGGCTCCGG
GACTGGGCCCCACGGCAGACACACAAGGTCATCCCCTTGAAAGGCCTGTGGGAGGATGTG
GCACCCACCCTGCCTGACGGTCACTTTGATGGGATCCTGTACGACACGTACCCACTCTCG
GAGGAGACCTGGCACACACACCAGTTCAACTTCATCAAGAACCACGCCTTTCGCCTGCTG
AAGCCGGGGGGCGTCCTCACCTACTGCAACCTCACCTCCTGGGGGGAGCTGATGAAGTCC
AAGTACTCAGACATCACCATCATGTTTGAGGAGACGCAGGTGCCCGCGCTGCTGGAGGCC
GGCTTCCGGAGGGAGAACATCCGTACGGAGGTGATGGCGCTGGTCCCACCGGCCGACTGC
CGCTACTACGCCTTCCCACAGATGATCACGCCCCTGGTGACCAAAGGCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
Z49878

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_2_Locus:
19p13.3

# Metabolic_Enzyme_2_SNPs:
rs17851582; rs659455; rs659460; rs266806; rs266808; rs9973220; rs2074899; rs266807; rs3786974; rs266813; rs266815; rs3888624; rs36040336; rs266814; rs11551914; rs1050914; rs11551915; rs11670139; rs4316878; rs266809; rs576699; rs3760991; rs3760992; rs3888625; rs266811; rs266812; rs3837984; rs3760990; rs266810; rs35696696; rs1142530; rs11666067; rs11672484; rs2074895; rs2074896; rs2074897; rs2074898; rs2240605; rs265271; rs3786975; rs3786976; rs502121; rs5024535; rs5024536; rs5024537; rs619693; rs7254913; rs7256647; rs7258846; rs809359

# Metabolic_Enzyme_2_General_References:
8547310; 9325156

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6118

# Metabolic_Enzyme_3_Name:
Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic

# Metabolic_Enzyme_3_Synonyms:
GPD-C; GPDH-C

# Metabolic_Enzyme_3_Gene_Name:
GPD1

# Metabolic_Enzyme_3_Protein_Sequence:
>Glycerol3phosphate dehydrogenase NAD+, cytoplasmic
MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHEN
VKYLPGHKLPPNVVAVPDVVQAAEDADILIFVVPHQFIGKICDQLKGHLKANATGISLIK
GVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCETTIGCKDPAQGQLLKEL
MQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAK
LFCSGPVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGP
ETARELYSILQHKGLVDKFPLFMAVYKVCYEGQPVGEFIHCLQNHPEHM

# Metabolic_Enzyme_3_Number_of_Residues:
349

# Metabolic_Enzyme_3_Molecular_Weight:
37568

# Metabolic_Enzyme_3_Theoretical_pI:
6.10

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  glycerol-3-phosphate dehydrogenase (NAD+) activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
 ||
>>>
Process:  glycerol-3-phosphate catabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  polyol metabolism
Process:  glycerol metabolism
Process:  glycerol-3-phosphate metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm
Component:  protein complex
Component:  unlocalized protein complex
Component:  glycerol-3-phosphate dehydrogenase complex

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH

# Metabolic_Enzyme_3_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_3_Reaction:
sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF07479:NAD_Gly3P_dh_C;
PF01210:NAD_Gly3P_dh_N

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.1.1.8

# Metabolic_Enzyme_3_GenBank_ID_Protein:
508487

# Metabolic_Enzyme_3_SwissProt_ID:
GPDA_HUMAN (P21695)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
GPD1

# Metabolic_Enzyme_3_Geneatlas_id:
GPD1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:4455

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>1050 bp
ATGGCTAGCAAGAAAGTCTGCATTGTAGGCTCCGGGAACTGGGGCTCAGCCATCGCCAAG
ATCGTGGGTGGCAATGCAGCCCAGCTCGCACAGTTTGACCCACGGGTGACCATGTGGGTA
TTTGAGGAAGACATTGGAGGCAAAAAGCTGACTGAGATCATCAACACGCAGCATGAGAAT
GTCAAATACCTGCCAGGGCACAAGTTGCCCCCAAATGTGGTGGCTGTCCCAGATGTGGTC
CAGGCTGCAGAGGATGCTGACATCCTGATCTTTGTGGTGCCCCATCAGTTCATCGGCAAG
ATCTGTGACCAGCTCAAGGGCCATCTGAAGGCAAACCCCACTGGCATATCTCTTATTAAG
GGGGTAGACGAGGGCCCCAATGGGCTGAAGCTCATCTCGGAAGTGATTGGGGAGCGCCTC
GGCATCCCCATGAGTGTGCTGATGGGGGCCAACATTGCCAGCGAGGTGGCTGATGAGAAG
TTCTGTGAGACAACCATTGGCTGCAAGGACCCGGCCCAGGGACAACTCCTGAAAGAGCTG
ATGCAGACACCAAACTTCCGTATCACAGTGGTGCAAGAGGTGGACACAGTAGAGATCTGT
GGAGCCTTAAAGAATGTAGTGGCCGTGGGGGCTGGCTTCTGTGATGGCCTGGGCTTTGGC
GACAACACCAAGGCGGCAGTGATCCGGCTGGGACTCATGGAGATGATAGCCTTCGCCAAG
CTCTTCTGCAGTGGCCCTGTGTCCTCTGCCACCTTCTTGGAGAGCTGTGGTGTTGCTGAC
CTGATCACTACCTGCTATGGAGGGCGGAACCGGAAAGTGGCTGAGGCCTTTGCGCGTACA
GGAAAGTCCATTGAGCAGCTGGAGAAAGAGTTGCTGAATGGGCAGAAACTGCAGGGGCCC
GAGACAGCCCGGGAGCTATACAGCATCCTCCAGCACAAGGGCCTGGTAGACAAGTTTCCC
TTGTTCATGGCTGTGTACAAGGTGTGCTACGAGGGCCAGCCAGTGGGTGAATTCATCCAC
TGCCTGCAGAATCATCCAGAACATATGTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
L34041

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_3_Locus:
12q12-q13

# Metabolic_Enzyme_3_SNPs:
rs2232202; rs836180; rs836178; rs836179; rs2232208; rs1128867; rs35428353; rs34944386; rs11541968; rs2232207; rs34783513; rs1046194; rs17848998; rs34423210; rs34013306; rs35256655; rs34005044; rs2232203; rs17848997; rs2232206; rs2232205; rs34537997; rs34025341; rs17848999; rs34926030; rs2232209; rs2232204; rs17848996; rs3813525; rs3841318; rs3813524; rs1050728; rs1050729; rs1059627; rs1063528; rs10817; rs12309742; rs1389280; rs1554844; rs17124432; rs17124448; rs7139363; rs7307230; rs7308474; rs7961065; rs7961112; rs7968119; rs836172; rs836177

# Metabolic_Enzyme_3_General_References:
7772607; 2398890

# Metabolic_Enzyme_3_References:
16896224; 16943074

# Metabolic_Enzyme_4_ID:
6117

# Metabolic_Enzyme_4_Name:
Glycerol kinase

# Metabolic_Enzyme_4_Synonyms:
ATP:glycerol 3-phosphotransferase; Glycerokinase; GK

# Metabolic_Enzyme_4_Gene_Name:
GK

# Metabolic_Enzyme_4_Protein_Sequence:
>Glycerol kinase
MAASKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEI
LHSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKITGEPLYNAVVWLDLRTQ
STVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEKRALFGTIDS
WLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKQLCEFFGIPMEILPNVRSSSEIY
GLMKAGALEGVPISGCLGDQSAALVGQMCFQIGQAKNTYGTGCFLLCNTGHKCVFSDHGL
LTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKTSEEIEKLAKEVGTSYGCYF
VPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLS
HLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLS
AVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSPESGIP

# Metabolic_Enzyme_4_Number_of_Residues:
524

# Metabolic_Enzyme_4_Molecular_Weight:
57490

# Metabolic_Enzyme_4_Theoretical_pI:
6.25

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  glycerol kinase activity
 ||
>>>
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  polyol metabolism
Process:  glycerol metabolism
Process:  glycerol-3-phosphate metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
Key enzyme in the regulation of glycerol uptake and metabolism

# Metabolic_Enzyme_4_Pathway:
map00561  Glycerolipid metabolism

# Metabolic_Enzyme_4_Reaction:
ATP + glycerol = ADP + sn-glycerol 3-phosphate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF02782:FGGY_C;
PF00370:FGGY_N

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.7.1.30

# Metabolic_Enzyme_4_GenBank_ID_Protein:
348167

# Metabolic_Enzyme_4_SwissProt_ID:
GLPK_HUMAN (P32189)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
GK

# Metabolic_Enzyme_4_Geneatlas_id:
GK

# Metabolic_Enzyme_4_hgnc_id:
HGNC:4289

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; peripheral membrane protein; cytoplasmic side. Cytoplasm. Note=In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm

# Metabolic_Enzyme_4_Gene_Sequence:
>1575 bp
ATGGCAGCCTCAAAGAAGGCAGTTTTGGGGCCATTGGTGGGGGCGGTGGACCAGGGCACC
AGTTCGACGCGCTTTTTGGTTTTCAATTCAAAAACAGCTGAACTACTTAGTCATCATCAA
GTAGAAATAAAACAAGAGTTCCCAAGAGAAGGATGGGTGGAACAGGACCCTAAGGAAATT
CTACATTCTGTCTATGAGTGTATAGAGAAAACATGTGAGAAACTTGGACAGCTCAATATT
GATATTTCCAACATAAAAGCTATTGGTGTCAGCAACCAGAGGGAAACCACTGTAGTCTGG
GACAAGATAACTGGAGAGCCTCTCTACAATGCTGTGGTGTGGCTTGATCTAAGAACCCAG
TCTACCGTTGAGAGTCTTAGTAAAAGAATTCCAGGAAATAATAACTTTGTCAAGTCCAAG
ACAGGCCTTCCACTTAGCACTTACTTCAGTGCAGTGAAACTTCGTTGGCTCCTTGACAAT
GTGAGAAAAGTTCAAAAGGCCGTTGAAGAAAAACGAGCTCTTTTTGGGACTATTGATTCA
TGGCTTATTTGGAGTTTGACAGGAGGAGTCAATGGAGGTGTCCACTGTACAGATGTAACA
AATGCAAGTAGGACTATGCTTTTCAACATTCATTCTTTGGAATGGGATAAACAACTCTGC
GAATTTTTTGGAATTCCAATGGAAATTCTTCCAAATGTCCGGAGTTCTTCTGAGATCTAT
GGCCTAATGAAAGCTGGGGCCTTGGAAGGTGTGCCAATATCTGGGTGTTTAGGGGACCAG
TCTGCTGCATTGGTGGGACAAATGTGCTTCCAGATTGGACAAGCCAAAAATACGTATGGA
ACAGGATGTTTCTTACTATGTAATACAGGCCATAAGTGTGTATTTTCTGATCATGGCCTT
CTCACCACAGTGGCTTACAAACTTGGCAGAGACAAACCAGTATATTATGCTTTGGAAGGT
TCTGTAGCTATAGCTGGTGCTGTTATTCGCTGGCTAAGAGACAATCTTGGAATTATAAAG
ACCTCAGAAGAAATTGAAAAACTTGCTAAAGAAGTAGGTACTTCTTATGGCTGCTACTTC
GTCCCAGCATTTTCGGGGTTATATGCACCTTATTGGGAGCCCAGCGCAAGAGGGATAATC
TGTGGACTCACTCAGTTCACCAATAAATGCCATATTGCTTTTGCTGCATTAGAAGCTGTT
TGTTTCCAAACTCGAGAGATTTTGGATGCCATGAATCGAGACTGTGGAATTCCACTCAGT
CATTTGCAGGTAGATGGAGGAATGACCAGCAACAAAATTCTTATGCAGCTACAAGCAGAC
ATTCTGTATATACCAGTAGTGAAGCCCTCAATGCCCGAAACCACTGCACTGGGTGCGGCT
ATGGCGGCAGGGGCTGCAGAAGGAGTCGGCGTATGGAGTCTCGAACCCGAGGATTTGTCT
GCCGTCACGATGGAGCGGTTTGAACCTCAGATTAATGCGGAGGAAAGTGAAATTCGTTAT
TCTACATGGAAGAAAGCTGTGATGAAGTCAATGGGTTGGGTTACAACTCAATCTCCAGAA
AGTGGTATTCCATAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
L13943

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_4_Locus:
Xp21.3

# Metabolic_Enzyme_4_SNPs:
rs17854202; rs34795481; rs5926945; rs1803659; rs5972222; rs931240; rs5927582; rs6527003; rs619; rs728149; rs4636357; rs12844553; rs4487947; rs6527002; rs5972211; rs5927593; rs1482834; rs6526991; rs5927587; rs6526997; rs5927596; rs5927584; rs4077820; rs12843585; rs967785; rs5927589; rs5972207; rs4609338; rs12560212; rs6526996; rs5926944; rs5927595; rs2868571; rs5926942; rs5972213; rs2035432; rs620; rs12854653; rs12011728; rs16989176; rs1871965; rs7058925; rs7878037; rs5927585; rs16989169; rs5927594; rs6526995; rs5972206; rs6631156; rs12010068; rs4617310; rs12007993; rs5972204; rs5971513; rs12851094; rs5972202; rs7879845; rs2035431; rs4345726; rs5972203; rs12557274; rs5927588; rs12009986; rs5927590; rs5926943; rs5927581; rs5927599; rs2170611; rs11095189; rs17854203; rs17857267; rs5927597; rs5972217; rs5972215; rs5927598; rs5972216; rs5926946; rs3931219; rs5972219; rs34867477; rs5972221; rs5972220; rs5972218; rs41302637; rs34792758; rs35918035; rs35586363; rs36091656; rs41305205; rs34365099; rs10644351; rs4829198; rs5971511; rs34992170; rs41311819; rs34773549; rs6631159; rs35313243; rs34172820; rs35124133; rs6631151; rs10682299; rs6631142; rs34474761; rs35688593; rs35784640; rs5927591; rs35182768; rs5927580; rs28366724; rs35849427; rs34275810; rs12847609; rs6631141; rs6628544; rs5971512; rs35027105; rs5927586; rs6631158; rs5926938; rs35498618; rs35856351; rs5926941; rs6631155; rs10656820; rs35354095; rs35120364; rs5927592; rs35987506; rs35931680; rs4415475; rs11281728; rs5926940; rs11306027; rs6631140; rs34129824; rs35468110; rs12007023; rs28697906; rs6631157; rs6631144; rs35791116; rs5972209; rs28390198; rs41309689; rs34160985; rs5926939; rs35547075; rs3838210; rs41311491; rs12843247; rs12845821; rs35183149; rs35290317; rs12007026; rs3747459; rs5972210; rs5972205; rs11282593; rs6631143; rs11349869; rs36091714; rs34474103; rs6631161; rs34088900; rs12007087; rs6631146; rs11417266; rs35182714; rs12862589; rs34301411; rs36133772; rs12844258; rs11461651; rs12011679; rs4486355; rs6631150; rs11400828; rs34773915; rs3838209; rs34462788; rs12007053; rs2868570; rs5927606; rs5927607; rs5972224; rs6526989; rs6527012; rs6653843; rs7049882

# Metabolic_Enzyme_4_General_References:
8401584; 7987308; 8499912; 8499898; 8651297; 9719371; 10736265

# Metabolic_Enzyme_4_References:
16306139; 16391030; 16524879

# Metabolic_Enzyme_5_ID:
6829

# Metabolic_Enzyme_5_Name:
Mitogen-activated protein kinase 10

# Metabolic_Enzyme_5_Synonyms:
Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3; MAP kinase p49 3F12

# Metabolic_Enzyme_5_Gene_Name:
MAPK10

# Metabolic_Enzyme_5_Protein_Sequence:
>Mitogenactivated protein kinase 10
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR

# Metabolic_Enzyme_5_Number_of_Residues:
464

# Metabolic_Enzyme_5_Molecular_Weight:
52586

# Metabolic_Enzyme_5_Theoretical_pI:
6.78

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity

# Metabolic_Enzyme_5_Pathway:
Not Available

# Metabolic_Enzyme_5_Reaction:
Not Available

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00069:Pkinase

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.7.11.24

# Metabolic_Enzyme_5_GenBank_ID_Protein:
468151

# Metabolic_Enzyme_5_SwissProt_ID:
MK10_HUMAN (P53779)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
MAPK10

# Metabolic_Enzyme_5_Geneatlas_id:
MAPK10

# Metabolic_Enzyme_5_hgnc_id:
HGNC:6872

# Metabolic_Enzyme_5_PDB_ID:
1JNK

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1269 bp
ATGAGCCTCCATTTCTTATACTACTGCAGTGAACCAACATTGGATGTGAAAATTGCCTTT
TGTCAGGGATTCGATAAACAAGTGGATGTGTCATATATTGCCAAACATTACAACATGAGC
AAAAGCAAAGTTGACAACCAGTTCTACAGTGTGGAAGTGGGAGACTCAACCTTCACAGTT
CTCAAGCGCTACCAGAATCTAAAGCCTATTGGCTCTGGGGCTCAGGGCATAGTTTGTGCC
GCGTATGATGCTGTCCTTGACAGAAATGTGGCCATTAAGAAGCTCAGCAGACCCTTTCAG
AACCAAACACATGCCAAGAGAGCGTACCGGGAGCTGGTCCTCATGAAGTGTGTGAACCAT
AAAAACATTATTAGTTTATTAAATGTCTTCACACCCCAGAAAACGCTGGAGGAGTTCCAA
GATGTTTACTTAGTAATGGAACTGATGGATGCCAACTTATGTCAAGTGATTCAGATGGAA
TTAGACCATGAGCGAATGTCTTACCTGCTGTACCAAATGTTGTGTGGCATTAAGCACCTC
CATTCTGCTGGAATTATTCACAGGGATTTAAAACCAAGTAACATTGTAGTCAAGTCTGAT
TGCACATTGAAAATCCTGGACTTTGGACTGGCCAGGACAGCAGGCACAAGCTTCATGATG
ACTCCATATGTGGTGACACGTTATTACAGAGCCCCTGAGGTCATCCTGGGGATGGGCTAC
AAGGAGAACGTGGATATATGGTCTGTGGGATGCATTATGGGAGAAATGGTTCGCCACAAA
ATCCTCTTTCCAGGAAGGGACTATATTGACCAGTGGAATAAGGTAATTGAACAACTAGGA
ACACCATGTCCAGAATTCATGAAGAAATTGCAACCCACAGTAAGAAACTATGTGGAGAAT
CGGCCCAAGTATGCGGGACTCACCTTCCCCAAACTCTTCCCAGATTCCCTCTTCCCAGCG
GACTCCGAGCACAATAAACTCAAAGCCAGCCAAGCCAGGGACTTGTTGTCAAAGATGCTA
GTGATTGACCCAGCAAAAAGAATATCAGTGGACGACGCCTTACAGCATCCCTACATCAAC
GTCTGGTATGACCCAGCCGAAGTGGAGGCGCCTCCACCTCAGATATATGACAAGCAGTTG
GATGAAAGAGAACACACAATTGAAGAATGGAAAGAACTTATCTACAAGGAAGTAATGAAT
TCAGAAGAAAAGACTAAAAATGGTGTAGTAAAAGGACAGCCTTCTCCTTCAGCACAGGTG
CAGCAGTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U07620

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_5_Locus:
4q22.1-q23

# Metabolic_Enzyme_5_SNPs:
rs1460763; rs1460767; rs1031738; rs2869444; rs1460759; rs2199308; rs1460769; rs2199309; rs1108429; rs2904101; rs1031737; rs2869438; rs2869421; rs1460756; rs1460753; rs2290882; rs4611890; rs10008238; rs7670728; rs11097100; rs6810895; rs10010011; rs6825707; rs10029339; rs4693145; rs4693142; rs1903360; rs11097104; rs11097099; rs7655217; rs1599313; rs6531910; rs12499006; rs1460760; rs10213453; rs7349681; rs6531906; rs6855169; rs7694034; rs7666454; rs12650052; rs12505566; rs12512375; rs6531914; rs6825506; rs7699555; rs11932806; rs7687771; rs11943376; rs6810839; rs9884127; rs12507758; rs1460751; rs10004539; rs6531925; rs4132490; rs6817452; rs2904094; rs4385018; rs1903361; rs6858306; rs12641387; rs12509960; rs1031739; rs3926499; rs12498980; rs2869424; rs1460758; rs1460766; rs6829923; rs10021706; rs6531913; rs4693135; rs6531921; rs4235080; rs2904095; rs1599314; rs10213444; rs6531909; rs4693139; rs6839160; rs1460750; rs6845742; rs9999403; rs6531926; rs6531924; rs6531916; rs6852305; rs2290881; rs12646571; rs11097109; rs11938088; rs9990599; rs11736313; rs1460752; rs7654796; rs4608765; rs12505959; rs6832259; rs7666231; rs1460757; rs6829870; rs2904097; rs6811046; rs10856859; rs6531911; rs9307018; rs2904090; rs2869437; rs6531905; rs6828947; rs7678480; rs9994931; rs12513293; rs958; rs12513374; rs4235079; rs7680934; rs4693765; rs12648265; rs10010952; rs2904096; rs2199307; rs4597789; rs7669060; rs12511071; rs6823664; rs2869435; rs10011429; rs11939109; rs6531923; rs7656914; rs6844365; rs6531907; rs6827698; rs11097103; rs11097110; rs10213451; rs7665868; rs12505595; rs6845605; rs12640395; rs2869431; rs1460761; rs4693766; rs6531915; rs7695155; rs12512698; rs7667999; rs7690384; rs11946235; rs10516768; rs7669487; rs2869436; rs12507513; rs7684258; rs12505532; rs17451111; rs1466380; rs17409925; rs6825521; rs1460754; rs17253274; rs12505336; rs7694920; rs6826702; rs2904099; rs7684081; rs11930495; rs13115429; rs6822338; rs11941150; rs7674849; rs6531922; rs2869432; rs13115172; rs12508545; rs6531918; rs2035056; rs12503051; rs11097107; rs6851183; rs17011890; rs7695707; rs7688633; rs12508801; rs11097108; rs11941484; rs4114893; rs7699065; rs7669675; rs6531927; rs2904105; rs2869433; rs7677400; rs12646021; rs11929810; rs13129883; rs13146797; rs11929779; rs12498923; rs6821819; rs11726269; rs11942064; rs12513237; rs10516771; rs4693763; rs13111170; rs11097098; rs12511667; rs12640392; rs7699047; rs17011519; rs6842671; rs17449485; rs11947870; rs6531928; rs7684469; rs13104178; rs10516774; rs12508939; rs7683561; rs6852494; rs6531917; rs17417318; rs6851604; rs7657056; rs13132206; rs6844363; rs7699333; rs13138286; rs11944466; rs12501551; rs17409687; rs1380922; rs9654156; rs12510302; rs11929783; rs17011893; rs11935211; rs17011645; rs11946258; rs9997633; rs17011756; rs12645370; rs7685419; rs4488910; rs6829766; rs7668374; rs4693143; rs17011584; rs7688651; rs2126021; rs6856688; rs12508372; rs11725943; rs12505800; rs6531912; rs4693140; rs12511114; rs7684518; rs17011445; rs7683909; rs10516773; rs10003259; rs10516770; rs2035057; rs17409311; rs10030319; rs7655797; rs12502371; rs12508579; rs11097102; rs2904102; rs2869439; rs12508286; rs7678392; rs10026060; rs12644920; rs7678691; rs10516769; rs11932102; rs9654157; rs13130598; rs1599312; rs4693144; rs6844343; rs7691626; rs7699105; rs12500132; rs10034428; rs17449015; rs7440491; rs7656010; rs2869422; rs11737795; rs6849834; rs12510373; rs4613534; rs4389539; rs17011705; rs922195; rs17011617; rs12513122; rs6531904; rs12513353; rs1460755; rs7685683; rs10516772; rs2904093; rs7698274; rs10022904; rs4693141; rs11097106; rs12504127; rs7437117; rs12500543; rs9307016; rs4693761; rs16996040; rs12501743; rs17418062; rs17011654; rs7684570; rs7679269; rs6827098; rs12504929; rs13146802; rs17011479; rs17011870; rs17011564; rs4693764; rs11726550; rs17011659; rs7696982; rs12649297; rs17011402; rs4693137; rs17011489; rs10016847; rs11725624; rs6830872; rs17011568; rs17415651; rs17011516; rs7684758; rs17450224; rs7677251; rs12500319; rs6814005; rs17011467; rs6847300; rs12646076; rs17452273; rs17011913; rs3733367; rs17011621; rs10035072; rs7689808; rs1380923; rs769378; rs6853248; rs9715454; rs10019269; rs17011457; rs7687046; rs6827405; rs2869423; rs1841427; rs6843457; rs11097101; rs11943324; rs9762809; rs17409527; rs17449147; rs10010751; rs1460762; rs10009161; rs12504532; rs17011731; rs6836561; rs17011611; rs17011847; rs10025305; rs7687161; rs12651511; rs17011653; rs7696980; rs17011419; rs7661197; rs7663388; rs6827483; rs10028202; rs6826762; rs6816691; rs9762806; rs17011588; rs17011421; rs17011575; rs12331353; rs7687972; rs12505443; rs7693923; rs6832461; rs17011396; rs17011409; rs7662140; rs6851072; rs4449380; rs12499209; rs17011458; rs10030225; rs17011492; rs9997175; rs12511602; rs17011592; rs17011547; rs11943129; rs2869430; rs17011630; rs1841426; rs10031237; rs17418221; rs17409478; rs12509902; rs11931871; rs17011649; rs6831576; rs12507860; rs17011487; rs769377; rs9762814; rs17011843; rs17417758; rs17408832; rs17011623; rs12503520; rs6847482; rs10034589; rs17011472; rs7696316; rs12640131; rs7654907; rs17011607; rs17011400; rs1903362; rs17011460; rs12508926; rs6818726; rs1460765; rs4521313; rs13112020; rs12509769; rs17011577; rs17409637; rs17011875; rs10026338; rs12646706; rs10470881; rs17449582; rs7691172; rs13140626; rs12502087; rs17011410; rs11935348; rs6841973; rs12506828; rs6829684; rs12498902; rs7661679; rs17011397; rs11097105; rs7676652; rs17011432; rs3762915; rs17011590; rs17011459; rs11947620; rs13110630; rs10006563; rs17011551; rs6811435; rs7663763; rs1318492; rs6531908; rs1903363; rs6842530; rs17011526; rs7663773; rs6813859; rs6817640; rs10019871; rs10030197; rs17408881; rs12500023; rs6831589; rs7682129; rs17011803; rs12511499; rs7697017; rs7661809; rs6813724; rs9994380; rs7690323; rs17011537; rs4371581; rs17011522; rs4693753; rs17451306; rs10006000; rs1460764; rs13112340; rs1460749; rs17011533; rs10003756; rs17011428; rs12511135; rs9996693; rs7698396; rs6845334; rs6824346; rs17011556; rs2904100; rs10213302; rs17409904; rs17011821; rs17011407; rs6826951; rs17011655; rs7667204; rs13115030; rs4299551; rs13140948; rs17011573; rs2035058; rs17011540; rs2009855; rs6847635; rs12500076; rs9994303; rs2589506; rs1436527; rs2589514; rs1436524; rs1469869; rs1436521; rs2589518; rs1541998; rs2282596; rs1946733; rs6822478; rs7435363; rs4403040; rs4693754; rs10004712; rs4235078; rs1898248; rs12502902; rs4546235; rs3775187; rs4352468; rs4334746; rs4613557; rs10028075; rs2118044; rs2282598; rs10031752; rs6531898; rs1436529; rs4501213; rs3775169; rs4377581; rs4482754; rs4364253; rs6821745; rs12647176; rs10024003; rs4407492; rs12639693; rs10001480; rs9307015; rs6856450; rs3775166; rs9884282; rs3775184; rs7692508; rs6810413; rs4133139; rs11929863; rs4487330; rs12642887; rs4693757; rs6854208; rs3775181; rs9995879; rs6848433; rs12650286; rs2282597; rs3775168; rs6815306; rs3775182; rs7692460; rs12640230; rs3775164; rs10212744; rs4530621; rs3775183; rs11097091; rs2575673; rs17011341; rs10009993; rs12644947; rs3775170; rs4414944; rs13103374; rs9307014; rs12647506; rs12502934; rs1469870; rs7670470; rs10003556; rs4446299; rs13112959; rs2575672; rs3775173; rs1436522; rs9884770; rs3775180; rs4351013; rs7692676; rs10033283; rs3775167; rs10212952; rs11097094; rs6531897; rs2043649; rs1010778; rs10020650; rs3775171; rs10011390; rs1002484; rs6531892; rs746438; rs4693136; rs7684198; rs11934691; rs7689936; rs3775176; rs17011324; rs6842186; rs10027764; rs4414943; rs7670786; rs4499692; rs7696878; rs6822410; rs10516763; rs7670681; rs13142206; rs12644938; rs10023731; rs3822036; rs3775175; rs11733961; rs11097092; rs17008675; rs2043650; rs6531893; rs12643642; rs7659520; rs12648064; rs10001162; rs9684602; rs17011322; rs5004884; rs12642872; rs17011339; rs17011349; rs10006261; rs2043648; rs4382028; rs7691896; rs6855234; rs9760017; rs10034271; rs1561154; rs10018678; rs4693756; rs10025882; rs6811151; rs10002407; rs2282599; rs10776485; rs4560400; rs4522858; rs10009942; rs3775185; rs7654005; rs3755971; rs1898249; rs3822037; rs13114632; rs6531891; rs6846365; rs9996208; rs6854511; rs7697197; rs7686599; rs17011355; rs6840318; rs13103861; rs13121113; rs5006575; rs12512583; rs2282595; rs7439672; rs12648171; rs11934127; rs2575674; rs7699978; rs2589515; rs1201; rs2575675; rs1202; rs2589516; rs12512524; rs17011312; rs10032602; rs17011314; rs7660160; rs28760360; rs34414912; rs17450827; rs34255377; rs35547091; rs34168022; rs17011766; rs4458422; rs28536101; rs34262586; rs35517015; rs35294861; rs35501076; rs4608763; rs6849947; rs4129300; rs11435039; rs4269144; rs5860021; rs7436985; rs10534985; rs28896887; rs35116135; rs1115229; rs35217429; rs10671229; rs17416927; rs28839895; rs3527; rs7661648; rs17450910; rs13140380; rs35435792; rs34369854; rs17011858; rs34455560; rs9968336; rs35140130; rs3029315; rs35842829; rs12498558; rs7442188; rs28489900; rs28804774; rs28834688; rs7695670; rs35882077; rs35610513; rs34648043; rs34904465; rs6815085; rs28830848; rs17011643; rs34442411; rs35257599; rs35178184; rs11943866; rs34265383; rs28421956; rs4693769; rs17011682; rs34328856; rs35085432; rs35034762; rs7691277; rs33970548; rs35338513; rs35581530; rs11278816; rs34061649; rs34304791; rs35461035; rs13124817; rs34743167; rs35892134; rs7376405; rs17409269; rs11330422; rs35492319; rs36216983; rs17011720; rs13113317; rs10539886; rs13149041; rs6839310; rs28733919; rs17011696; rs34683010; rs10608638; rs4561895; rs4994993; rs36228436; rs7679167; rs28520822; rs28695505; rs34809402; rs34253891; rs34870954; rs28463620; rs28670086; rs28722990; rs7675381; rs9307017; rs34885616; rs17011700; rs28534721; rs34954949; rs35572072; rs34989577; rs35859687; rs35240319; rs10600798; rs35991788; rs4618275; rs35774265; rs13124872; rs11947890; rs28450091; rs9998205; rs33949420; rs3030118; rs35450214; rs3030160; rs12644976; rs13126246; rs6850992; rs35900214; rs33991102; rs34241060; rs28373627; rs34593390; rs28661214; rs7697335; rs34125064; rs35130751; rs35441446; rs6844636; rs35767206; rs35145865; rs13126021; rs13113315; rs6836359; rs35826931; rs7690940; rs28408117; rs9654155; rs35063332; rs34696102; rs17011690; rs6856862; rs33929180; rs7673423; rs35083678; rs35343868; rs12644859; rs36021595; rs2001612; rs10681488; rs28791572; rs13145464; rs13113328; rs35965801; rs34448816; rs5860022; rs28694187; rs28890938; rs34498673; rs28536743; rs10545105; rs9761579; rs12500128; rs13116387; rs35427609; rs10016000; rs28434311; rs10591715; rs28705770; rs3971920; rs7672563; rs3217717; rs28821771; rs35079757; rs12650508; rs3030142; rs13129988; rs3029313; rs7688495; rs34505400; rs10714569; rs35097345; rs12643272; rs34201683; rs17417827; rs35609863; rs10014678; rs28427030; rs34111505; rs11944190; rs34111165; rs36223042; rs2219590; rs34184989; rs13140549; rs2169232; rs9994347; rs36076697; rs34790740; rs28870188; rs34783569; rs10639041; rs1460768; rs34676161; rs28626971; rs35003006; rs35334656; rs5860019; rs34911547; rs13124881; rs5860023; rs4434210; rs10711609; rs35968542; rs34447604; rs35808523; rs2869434; rs11728235; rs10716571; rs17011853; rs36004445; rs13118244; rs34637756; rs28613556; rs34024985; rs11284646; rs10538760; rs34570949; rs35129937; rs34800738; rs35795436; rs13112890; rs10639042; rs34816270; rs34609132; rs35817774; rs34547847; rs9761874; rs28515691; rs11439209; rs6531899; rs28416998; rs35412018; rs33976873; rs35103650; rs35022866; rs17011806; rs36124809; rs11730779; rs34575399; rs11942108; rs28847910; rs35757767; rs28406787; rs34973055; rs34192441; rs35160765; rs3030124; rs28702698; rs34721708; rs2007976; rs28803851; rs35324025; rs35888867; rs7437697; rs13132706; rs28664010; rs34477595; rs34503531; rs28755839; rs6844802; rs6853290; rs4693762; rs34748597; rs4349565; rs17011815; rs35573944; rs35122643; rs4450887; rs33935168; rs33945648; rs28830922; rs13145461; rs3030114; rs28734891; rs11097095; rs10550573; rs13124525; rs35907363; rs28444287; rs34243707; rs6831733; rs13148508; rs28722583; rs35977040; rs28759971; rs35108904; rs34854999; rs34863847; rs13116803; rs13126094; rs10708095; rs6836163; rs4575960; rs35272630; rs10549069; rs9998829; rs28559713; rs4608764; rs13113779; rs12501090; rs34163860; rs17011764; rs6850605; rs4132491; rs35788198; rs34332756; rs35118208; rs7677406; rs35867435; rs35288754; rs34210154; rs34914334; rs36211477; rs28411373; rs36078401; rs10020888; rs34364808; rs28404815; rs35161743; rs28803213; rs13140707; rs35212998; rs36184857; rs7675359; rs11458660; rs28630852; rs17011897; rs35173052; rs28816476; rs35031715; rs9715449; rs34743978; rs17011767; rs17011845; rs17011819; rs12650517; rs5860024; rs34063796; rs34805580; rs34544666; rs35455450; rs34043435; rs13136303; rs35816063; rs11460057; rs36057902; rs10020889; rs35443953; rs13434575; rs11097096; rs13140740; rs11404211; rs36023771; rs34608518; rs34467283; rs6810953; rs36041399; rs35960605; rs34388593; rs35240246; rs28425193; rs17011774; rs3030110; rs35952969; rs11734792; rs17011872; rs11339874; rs36092105; rs35696959; rs17011708; rs28583812; rs28722082; rs13117193; rs34440566; rs35443845; rs6844573; rs11931070; rs34404446; rs35565125; rs34624037; rs11722341; rs17409562; rs11941923; rs7442324; rs10642552; rs35087395; rs10639063; rs28812808; rs13140361; rs35463589; rs35199525; rs28433471; rs8180149; rs28572764; rs28826941; rs28792132; rs2035055; rs13136895; rs28849082; rs4994992; rs34215628; rs13124639; rs11944647; rs34238796; rs13145457; rs34601352; rs28411372; rs13126019; rs5860025; rs9714693; rs35869982; rs11932859; rs7699144; rs10012013; rs34470194; rs13147005; rs11097097; rs13112497; rs34486987; rs34813710; rs36101511; rs6814123; rs34135924; rs34034936; rs11936320; rs28783973; rs12331772; rs28529458; rs34328097; rs13134099; rs13120126; rs33935094; rs10538012; rs6856365; rs17011354; rs17405567; rs7681267; rs34159031; rs35755826; rs6856155; rs35865395; rs28514916; rs9760243; rs10027225; rs1436523; rs1987599; rs35218486; rs5860017; rs13111648; rs3836594; rs10856856; rs34899473; rs28552906; rs3775186; rs35404583; rs41457050; rs28399149; rs34537730; rs5860013; rs35663996; rs34749448; rs34122764; rs36212057; rs7681951; rs34850141; rs13148731; rs34756998; rs13104555; rs35660849; rs35588497; rs34998174; rs35833770; rs34581941; rs4289439; rs7692668; rs34476895; rs5022021; rs13125713; rs28578870; rs34929575; rs36216172; rs12503688; rs4572869; rs28485608; rs34729900; rs4479697; rs34807837; rs34836858; rs4693755; rs34074833; rs34494584; rs34641637; rs13125729; rs11447293; rs4305506; rs34490730; rs13110593; rs36051698; rs28602213; rs17011338; rs5860016; rs33967580; rs28564356; rs35529605; rs6833404; rs13137708; rs33915987; rs28886577; rs733245; rs35534226; rs35394196; rs34038586; rs34324822; rs11413469; rs34699430; rs34770162; rs28538268; rs28516651; rs34050480; rs35076380; rs11360333; rs34741254; rs5860012; rs10538907; rs13104186; rs4345173; rs3841985; rs34825310; rs5860015; rs35211423; rs7667297; rs13353771; rs6823292; rs6813473; rs6531890; rs36085847; rs34949899; rs3775174; rs3822035; rs28660296; rs10635481; rs35495063; rs34886510; rs13146800; rs28895314; rs35606170; rs28709251; rs13104858; rs6818736; rs28435171; rs35225779; rs28576440; rs34300479; rs33962451; rs4419471; rs36047555; rs35893712; rs35915959; rs6813767; rs28398988; rs993593; rs11464313; rs34890849; rs28538338; rs35985560; rs35971482; rs983362; rs6821840; rs35438921; rs13434461; rs35278948; rs28754957; rs35080222; rs35280239; rs35466444; rs34937342; rs7667730; rs35320793; rs36047328; rs4382027; rs35279016; rs34751931; rs1436525; rs34439623; rs34952784; rs35891526; rs35823399; rs28409011; rs33977029; rs34155854; rs5860011; rs5860014; rs11721577; rs6531896; rs28846216; rs34180438; rs35107154; rs11432370; rs28594219; rs35490865; rs35333179; rs41279295; rs13138031; rs6825701; rs34158309; rs33990825; rs11309220; rs34791873; rs35136227; rs36132996; rs2060588; rs28639372; rs35568742; rs1436526; rs36133086; rs33951909; rs28756326; rs35187473; rs41282389; rs6857877; rs6843159; rs34188118; rs34534392; rs33979648; rs34789840; rs35273363; rs6816545; rs34498081; rs35358194; rs28865277; rs28562760; rs34934309; rs34060265; rs3775172; rs9762665; rs34562438; rs28625279; rs34725089; rs13104097; rs34757256; rs28642002; rs35270911; rs28684379; rs7681273; rs35485855; rs35867054; rs28360921; rs34134501; rs28394598; rs34008671; rs35473638; rs34307500; rs35112097; rs7660151; rs10034578; rs17011284; rs17011286; rs17011297; rs17011308; rs1946734; rs2164535; rs2575676; rs2589509; rs2589523; rs2589525; rs3755970; rs4640664; rs7438872; rs7439032; rs7677101

# Metabolic_Enzyme_5_General_References:
7826642; 8654373; 10715136; 9739089

# Metabolic_Enzyme_5_References:
16287872; 16672381; 16980399

# Metabolic_Enzyme_6_ID:
8487

# Metabolic_Enzyme_6_Name:
Glycerol kinase, testis specific 1

# Metabolic_Enzyme_6_Synonyms:
ATP:glycerol 3- phosphotransferase; Glycerokinase; GK

# Metabolic_Enzyme_6_Gene_Name:
GK3P

# Metabolic_Enzyme_6_Protein_Sequence:
>Glycerol kinase, testis specific 1
MAASKKAVLGPLVGAVDQGTSSTRFLVFNSRTAELLSHHQVEIKQEFPREGWVEQDPKEI
LHSVYECIEKTCEKLGQLNIGISNIKAIGVSNQRETTVAWDKITGEPLYNAVVWLDLRTQ
STVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEKRALFGTIDS
WLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKQLCEFFGIPMEILPHVRSSSEIY
GLMKAGALEGVPISGCLGDQSAALVGQMCFQIGQAKNTYGTGCFLLCNTGHKCVFSDHGL
LTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKTSEEIEKLAKEVGTSYGCYF
VPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLS
HLQVDGGMTSNKILMQLQADILYIPVVKPLMPETTALGAAMAAGAAEGVDVWSLEPEDLS
AVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSPEGGDPSVFCSLPLGFFIVSSM
AMLIGARYISGIP

# Metabolic_Enzyme_6_Number_of_Residues:
553

# Metabolic_Enzyme_6_Molecular_Weight:
60570

# Metabolic_Enzyme_6_Theoretical_pI:
6.35

# Metabolic_Enzyme_6_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  glycerol kinase activity
 ||
>>>
 Process:  cellular metabolism
Process:  alcohol metabolism
Process:  polyol metabolism
Process:  glycerol metabolism
Process:  glycerol-3-phosphate metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Energy production and conversion

# Metabolic_Enzyme_6_Specific_Function:
Key enzyme in the regulation of glycerol uptake and metabolism

# Metabolic_Enzyme_6_Pathway:
map00561  Glycerolipid metabolism

# Metabolic_Enzyme_6_Reaction:
ATP + glycerol = ADP + sn-glycerol 3-phosphate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF02782:FGGY_C
PF00370:FGGY_N

# Metabolic_Enzyme_6_Signals:
Not Available

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.7.1.30

# Metabolic_Enzyme_6_GenBank_ID_Protein:
515029

# Metabolic_Enzyme_6_SwissProt_ID:
GLPK3_HUMAN (Q14409)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
GK3P

# Metabolic_Enzyme_6_Geneatlas_id:
GK3P

# Metabolic_Enzyme_6_hgnc_id:
HGNC:4292

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; peripheral membrane protein; cytoplasmic side. Cytoplasm (By similarity). Note=In sperm the majority of the enzyme is bound to mitochondria (By similarity)

# Metabolic_Enzyme_6_Gene_Sequence:
>1662 bp
ATGGCAGCCTCAAAGAAGGCAGTTTTGGGGCCATTGGTGGGGGCAGTGGACCAAGGCACC
AGTTCCACGCGCTTTTTGGTTTTCAATTCAAGAACAGCTGAACTACTTAGTCATCATCAA
GTGGAAATAAAACAAGAGTTCCCAAGAGAAGGATGGGTGGAACAGGACCCTAAGGAAATT
CTACATTCTGTCTATGAGTGTATAGAGAAAACATGTGAGAAACTTGGACAGCTCAATATT
GGTATTTCCAACATAAAAGCTATTGGTGTCAGCAACCAGAGGGAAACCACCGTAGCCTGG
GACAAGATAACTGGAGAGCCTCTCTACAATGCTGTAGTGTGGCTTGATCTAAGAACACAG
TCTACCGTTGAGAGTCTTAGTAAAAGAATTCCAGGAAATAATAACTTTGTCAAGTCCAAG
ACAGGCCTTCCACTTAGCACTTACTTCAGTGCAGTGAAACTTCGCTGGCTCCTCGACAAT
GTGAGAAAAGTTCAAAAGGCCGTTGAAGAAAAACGAGCTCTTTTTGGGACTATTGATTCA
TGGCTTATTTGGAGTTTGACAGGAGGCGTCAATGGAGGTGTCCACTGTACAGATGTAACA
AATGCAAGTAGGACTATGCTTTTCAACATTCATTCTTTGGAATGGGATAAACAACTCTGT
GAATTTTTTGGAATTCCAATGGAAATTCTTCCACATGTTCGGAGTTCTTCTGAGATCTAT
GGCCTAATGAAAGCGGGGGCCTTGGAAGGTGTGCCAATATCTGGGTGTTTAGGGGACCAG
TCTGCTGCACTGGTGGGACAAATGTGCTTCCAGATTGGACAAGCCAAAAATACGTATGGA
ACAGGATGTTTCTTACTATGTAATACAGGCCATAAGTGTGTATTTTCTGATCATGGCCTT
CTCACCACAGTGGCTTACAAACTTGGCAGAGACAAACCGGTATATTACGCTTTGGAAGGT
TCTGTAGCTATAGCTGGTGCTGTTATTCGCTGGCTAAGAGACAATCTTGGAATTATAAAG
ACCTCAGAAGAAATTGAAAAACTTGCTAAAGAAGTAGGTACTTCTTATGGCTGCTACTTC
GTCCCAGCATTTTCGGGGTTATATGCACCTTATTGGGAGCCCAGCGCAAGAGGGATAATC
TGTGGACTCACTCAATTCACGAATAAATGCCATATTGCTTTTGCTGCATTAGAAGCTGTT
TGTTTCCAAACTCGAGAGATTTTGGATGCCATGAATCGAGACTGTGGAATTCCACTCAGT
CATTTGCAGGTTGATGGAGGAATGACCAGCAACAAAATTCTTATGCAGCTACAAGCAGAC
ATTCTGTATATTCCAGTAGTGAAGCCCTTGATGCCCGAAACCACTGCACTGGGTGCTGCC
ATGGCGGCAGGGGCTGCAGAAGGAGTCGACGTATGGAGTCTTGAACCTGAGGATTTGTCC
GCCGTCACGATGGAGCGGTTTGAACCTCAGATTAATGCTGAGGAAAGTGAAATTCGTTAT
TCTACATGGAAGAAAGCTGTGATGAAGTCAATGGGTTGGGTTACAACTCAATCTCCAGAA
GGTGGTGACCCTAGTGTCTTCTGTAGTCTGCCCTTGGGCTTTTTTATAGTGAGTAGCATG
GCAATGTTAATCGGAGCAAGGTACATCTCAGGTATTCCATAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
X78711

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_6_Locus:
4q32.1

# Metabolic_Enzyme_6_SNPs:
Not Available

# Metabolic_Enzyme_6_General_References:
7987308

# Metabolic_Enzyme_6_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7549

# Macromolecular_Interacting_Partner_1_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
INS

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_1_Signals:
1-24

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
INS

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11p15.5

# Macromolecular_Interacting_Partner_1_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_1_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_1_References:
16051271; 16136819; 16651733

# Macromolecular_Interacting_Partner_2_ID:
7687

# Macromolecular_Interacting_Partner_2_Name:
Nucleobindin-2 precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
DNA-binding protein NEFA; Gastric cancer antigen Zg4

# Macromolecular_Interacting_Partner_2_Gene_Name:
NUCB2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Nucleobindin2 precursor
MRWRTILLQYCFLLITCLLTALEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQ
VIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKA
KLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKY
EMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLD
PNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREH
VMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENE
LKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQGIPPSGPAGELKFEPHI


# Macromolecular_Interacting_Partner_2_Number_of_Residues:
420

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
50223

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
4.78

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Replication, recombination and repair 

# Macromolecular_Interacting_Partner_2_Specific_Function:
Calcium-binding protein. May have a role in calcium homeostasis

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00036:efhand

# Macromolecular_Interacting_Partner_2_Signals:
1-24

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
436418

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
NUCB2_HUMAN (P80303)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
NUCB2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
NUCB2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:8044

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane; peripheral membrane protein. Cytoplasm. Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1263 bp
ATGAGGTGGAGGACCATCCTGCTACAGTATTGCTTTCTCTTGATTACATGTTTACTTACT
GCTCTTGAAGCTGTGCCTATTGACATAGACAAGACAAAAGTACAAAATATTCACCCTGTG
GAAAGTGCGAAGATAGAACCACCAGATACTGGACTTTATTATGATGAATATCTCAAGCAA
GTGATTGATGTGCTGGAAACAGATAAACACTTCAGAGAAAAGCTCCAGAAAGCAGACATA
GAGGAAATAAAGAGTGGGAGGCTAAGCAAAGAACTGGATTTAGTAAGTCACCATGTGAGG
ACAAAACTTGATGAACTGAAAAGGCAAGAAGTAGGAAGGTTAAGAATGTTAATTAAAGCT
AAGTTGGATTCCCTTCAAGATATAGGCATGGACCACCAAGCTCTTCTAAAACAATTTGAT
CACCTAAACCACCTGAATCCTGACAAGTTTGAATCCACAGATTTAGATATGCTAATCAAA
GCGGCAACAAGTGATCTGGAACACTATGACAAGACTCGTCATGAAGAATTTAAAAAATAT
GAAATGATGAAGGAACATGAAAGGAGAGAATATTTAAAAACATTGAATGAAGAAAAGAGA
AAAGAAGAAGAGTCTAAATTTGAAGAAATGAAGAAAAAGCATGAAAATCACCCTAAAGTT
AATCACCCAGGAAGCAAAGATCAACTAAAAGAGGTATGGGAAGAGACTGATGGATTGGAT
CCTAATGACTTTGACCCCAAGACATTTTTCAAATTACATGATGTCAATAGTGATGGATTC
CTGGATGAACAAGAATTAGAAGCCCTATTTACTAAAGAGTTGGAGAAAGTATATGACCCT
AAAAATGAAGAGGATGATATGGTAGAAATGGAAGAAGAAAGGCTTAGAATGAGGGAACAT
GTAATGAATGAGGTTGATACTAACAAAGACAGATTGGTGACTCTGGAGGAGTTTTTGAAA
GCCACAGAAAAAAAAGAATTCTTGGAGCCAGATAGCTGGGAGACATTAGATCAGCAACAG
TTCTTCACAGAGGAAGAACTAAAAGAATATGAAAATATTATTGCTTTACAAGAAAATGAA
CTTAAGAAGAAGGCAGATGAGCTTCAGAAACAAAAAGAAGAGCTACAACGTCAGCATGAT
CAACTGGAGGCTCAGAAGCTGGAATATCATCAGGTCATACAGCAGATGGAACAAAAAAAA
TTACAACAAGGAATTCCTCCATCAGGGCCAGCTGGAGAATTGAAGTTTGAGCCACACATT
TAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
X76732

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_2_Locus:
11p15.1-p14

# Macromolecular_Interacting_Partner_2_SNPs:
rs757081; rs11024249; rs214075; rs214084; rs7127347; rs214067; rs214087; rs214105; rs214086; rs214076; rs214083; rs12286012; rs214081; rs214077; rs12419530; rs214106; rs214082; rs214108; rs1330; rs214068; rs214069; rs6486360; rs214104; rs214071; rs214080; rs10832756; rs12288942; rs214070; rs10832755; rs2051771; rs11024239; rs12286965; rs214085; rs12285450; rs12270204; rs12293623; rs12287274; rs11601108; rs214079; rs214072; rs12575240; rs10741725; rs10466382; rs2521999; rs10832763; rs10766383; rs2521997; rs9645621; rs11024246; rs10832757; rs2634462; rs11024254; rs12282915; rs7113434; rs11024251; rs10766384; rs12293814; rs6486362; rs12270010; rs10832762; rs11024243; rs10832759; rs12276066; rs7933137; rs12275837; rs1073443; rs10832758; rs10466383; rs11024253; rs12225041; rs10766385; rs10832760; rs11024250; rs12275573; rs16933963; rs16933952; rs10766387; rs11024244; rs10832764; rs16933946; rs214091; rs214090; rs186174; rs214088; rs2521998; rs34405111; rs12292418; rs35581886; rs2035688; rs2035687; rs2016686; rs34655620; rs35815322; rs184190; rs3064047; rs214073; rs214078; rs12270734; rs35843013; rs35863005; rs35448937; rs12272752; rs4029112; rs10589496; rs35873853; rs2354866; rs548503; rs34279210; rs10566571; rs214074; rs35737787; rs12285285; rs7935605; rs11024235; rs3064045; rs12280534; rs34319203; rs1042876; rs393405; rs34225021; rs34261355; rs11024238; rs11024234; rs35441492; rs12794099; rs11827162; rs5789983; rs548504; rs2035689; rs34520227; rs34261908; rs36016757; rs3064043; rs214107; rs12294998; rs34406631; rs10658598; rs531201; rs11024237; rs534867; rs34681843; rs1963780; rs28384099; rs11024247; rs12281007; rs12798286; rs2521996; rs12270012; rs34328259; rs12280741; rs11512064; rs34329500; rs34504224; rs12420722; rs214109; rs12421767; rs11024242; rs12279903; rs35980924; rs12792398; rs34865872; rs34457598; rs35747492; rs34683018; rs7107805; rs12361211; rs35545615; rs12361363; rs35543367; rs34234516; rs35226358; rs35275241; rs2634463; rs35702516; rs12276749; rs12574820; rs12281647; rs12273764; rs11024241; rs7350508; rs11525338; rs11024245; rs35264082; rs35143901; rs4582955; rs35839051; rs11024240; rs12291236; rs7480249; rs10466420; rs36049362; rs35262966; rs11024248; rs12270020; rs13377331; rs35054581; rs34639402; rs34452722; rs34538933; rs34966139; rs11024255; rs35857434; rs34471145; rs35491461; rs36045228; rs4757506; rs214089; rs12786482; rs10832767; rs11024256; rs12365375; rs12807715; rs214092; rs214093; rs214097; rs214101

# Macromolecular_Interacting_Partner_2_General_References:
7811391; 9639681; 12087473

# Macromolecular_Interacting_Partner_2_References:
16380488; 16427105; 16906479

# Macromolecular_Interacting_Partner_3_ID:
7803

# Macromolecular_Interacting_Partner_3_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_3_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_3_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_3_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_3_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_3_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_3_SNPs:
Not Available

# Macromolecular_Interacting_Partner_3_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_3_References:
16978154

# Macromolecular_Interacting_Partner_4_ID:
8292

# Macromolecular_Interacting_Partner_4_Name:
Aquaporin-7

# Macromolecular_Interacting_Partner_4_Synonyms:
AQP-7; Aquaporin-7-like; Aquaporin adipose; AQPap

# Macromolecular_Interacting_Partner_4_Gene_Name:
AQP7

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Aquaporin7
MVQASGHRRSTRGSKMVSWSVIAKIQEILQRKMVREFLAEFMSTYVMMVFGLGSVAHMVL
NKKYGSYLGVNLGFGFGVTMGVHVAGRISGAHMNAAVTFANCALGRVPWRKFPVYVLGQF
LGSFLAAATIYSLFYTAILHFSGGQLMVTGPVATAGIFATYLPDHMTLWRGFLNEAWLTG
MLQLCLFAITDQENNPALPGTEALVIGILVVIIGVSLGMNTGYAINPSRDLPPRIFTFIA
GWGKQVFSNGENWWWVPVVAPLLGAYLGGIIYLVFIGSTIPREPLKLEDSVAYEDHGITV
LPKMGSHEPTISPLTPVSVSPANRSSVHPAPPLHESMALEHF

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
342

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
37232

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
9.22

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_4_Specific_Function:
Forms a channel for water and glycerol

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00230:MIP

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
37-57
66-86
114-134
171-191
197-217
256-276

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
2317274

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
AQP7_HUMAN (O14520)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
AQP7

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
AQP7

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:640

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1029 bp
ATGGTTCAAGCATCCGGGCACAGGCGGTCCACCCGTGGCTCCAAAATGGTCTCCTGGTCC
GTGATAGCAAAGATCCAGGAAATACTGCAGAGGAAGATGGTGCGAGAGTTCCTGGCCGAG
TTCATGAGCACATATGTCATGATGGTATTCGGCCTTGGTTCCGTGGCCCATATGGTTCTA
AATAAAAAATATGGGAGCTACCTTGGTGTCAACTTGGGTTTTGGCTTCGGAGTCACCATG
GGAGTGCACGTGGCAGGCCGCATCTCTGGAGCCCACATGAACGCAGCTGTGACCTTTGCT
AACTGTGCGCTGGGCCGCGTGCCCTGGAGGAAGTTTCCGGTCTATGTGCTGGGGCAGTTC
CTGGGCTCCTTCCTGGCGGCTGCCACCATCTACAGTCTCTTCTACACGGCCATTCTCCAC
TTTTCGGGTGGACAGCTGATGGTGACCGGTCCCGTCGCTACAGCTGGCATTTTTGCCACC
TACCTTCCTGATCACATGACATTGTGGCGGGGCTTCCTGAATGAGGCGTGGCTGACCGGG
ATGCTCCAGCTGTGTCTCTTCGCCATCACGGACCAGGAGAACAACCCAGCACTGCCAGGA
ACAGAGGCGCTGGTGATAGGCATCCTCGTGGTCATCATCGGGGTGTCCCTTGGCATGAAC
ACAGGATATGCCATCAACCCGTCCCGGGACCTGCCCCCCCGCATCTTCACCTTCATTGCT
GGTTGGGGCAAACAGGTCTTCAGCAATGGGGAGAACTGGTGGTGGGTGCCAGTGGTGGCA
CCACTTCTGGGTGCCTATCTAGGTGGCATCATCTACCTGGTCTTCATTGGCTCCACCATC
CCACGGGAGCCCCTGAAATTGGAGGATTCTGTGGCGTATGAAGACCACGGGATAACCGTA
TTGCCCAAGATGGGATCTCATGAACCCACGATCTCTCCCCTCACCCCCGTCTCTGTGAGC
CCTGCCAACAGATCTTCAGTCCACCCTGCCCCACCCTTACATGAATCCATGGCCCTAGAG
CACTTCTAA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
AB006190

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_4_Locus:
9p13

# Macromolecular_Interacting_Partner_4_SNPs:
rs3569; rs3860983; rs2890584; rs3845232; rs12003438; rs13434; rs4008528; rs590111; rs4992816; rs586315; rs556390; rs642636; rs10971487; rs2989925; rs2992831; rs4008641; rs17251987; rs2777739; rs4879696; rs2380984; rs2989926; rs2380973; rs657095; rs2380985; rs3860976; rs11790323; rs2484931; rs4080365; rs558845; rs2484932; rs500278; rs16935913; rs4008654; rs7863490; rs657080; rs10116528; rs4879691; rs3758268; rs2989928; rs2989924; rs3758269; rs1055999; rs16935923; rs1134383; rs1055994; rs1055990; rs12000688; rs1055998; rs2247654; rs2381002; rs4008658; rs4008659; rs2381004; rs2381003; rs3877999; rs4008527; rs7869946; rs12553919; rs11555075; rs12553970; rs3860981; rs12551383; rs2021030; rs2984992; rs10971488; rs11388636; rs12553937; rs3936934; rs3036353; rs3860982; rs3878000; rs4008526; rs12555256; rs3954980; rs2381006; rs36017412; rs4879694; rs4008649; rs2380989; rs3860975; rs4008660; rs2236545; rs3954982; rs2381022; rs2381018; rs4008651; rs2380997; rs12352931; rs4008677; rs10971486; rs2321028; rs3954997; rs2380976; rs3895452; rs3931568; rs7044979; rs4008674; rs35483885; rs9407011; rs4120125; rs2890558; rs1810671; rs4879695; rs12346759; rs2380996; rs2380980; rs3860980; rs2381013; rs2380991; rs7036315; rs3967570; rs4008640; rs2380979; rs10971485; rs3860979; rs4008638; rs4008639; rs12683243; rs4008664; rs2890562; rs4879692; rs2785208; rs3065678; rs3877998; rs2381009; rs35066736; rs35696866; rs2381023; rs3954981; rs2381017; rs4008644; rs7022694; rs34238058; rs13300799; rs504770; rs4008652; rs2380988; rs2321029; rs4008632; rs2380998; rs2381020; rs4008648; rs3860978; rs3064817; rs2381001; rs4008673; rs2380974; rs7045129; rs33962618; rs2890559; rs2380993; rs4008655; rs4008663; rs4008627; rs34323333; rs2380992; rs34751626; rs2381012; rs2381024; rs2380999; rs13295977; rs35929867; rs4008653; rs4008636; rs1764351; rs4008642; rs2380982; rs7044946; rs2380990; rs35890843; rs10533009; rs2381008; rs34391457; rs35287894; rs12552638; rs4008643; rs2380987; rs4008529; rs4008676; rs3870387; rs12684236; rs2890561; rs35878654; rs34211641; rs35294363; rs12683898; rs2381019; rs4008647; rs2321030; rs2380977; rs2380994; rs10124065; rs3064823; rs12343165; rs2380983; rs4008530; rs35093222; rs4008661; rs3895312; rs4879693; rs7045054; rs4008656; rs4008628; rs2381016; rs35146742; rs4008637; rs4008634; rs2236546; rs4008650; rs2380981; rs2381000; rs2381011; rs12005589; rs10971484; rs2381007; rs2890560; rs2380975; rs4008671; rs4008657; rs2380995; rs4008646; rs4008672; rs2785207; rs5897545; rs2381010; rs11435699; rs4008645; rs2380978; rs4008630; rs34736076; rs3870386; rs3908843; rs4008675; rs3004351; rs2890557; rs2381014; rs2380986; rs11401583; rs2381015; rs3954983; rs12343286; rs3860977; rs11392660; rs1056000; rs12005633; rs1055992; rs4008670; rs12003516; rs4008667; rs34541601; rs2380972; rs1055989; rs16935920; rs10971490; rs34203132; rs34572210; rs4008666; rs12003520; rs1055997; rs34638529; rs1134388; rs4008665; rs1134384; rs4008669; rs12003531; rs10971489; rs1134392; rs12003564; rs12003509; rs4477118; rs4008668; rs3954979; rs34975317; rs2380971; rs3215969; rs34690144; rs10813971; rs10971492; rs12000611; rs12001813; rs12002300; rs12336144; rs12342594; rs12351969; rs12351974; rs17337873; rs2989929; rs3758267; rs4056754; rs549035; rs7028955; rs7029953; rs7039308; rs7045917; rs9696911

# Macromolecular_Interacting_Partner_4_General_References:
9405233

# Macromolecular_Interacting_Partner_4_References:
15998844

# Macromolecular_Interacting_Partner_5_ID:
8419

# Macromolecular_Interacting_Partner_5_Name:
Aquaporin-9

# Macromolecular_Interacting_Partner_5_Synonyms:
AQP-9; Small solute channel 1

# Macromolecular_Interacting_Partner_5_Gene_Name:
AQP9

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Aquaporin9
MQPEGAEKGKSFKQRLVLKSSLAKETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITI
NVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATV
FGIYYDGLMSFAGGKLLIVGENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIF
DSRNLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFRAG
NNFWWIPVVGPLVGAVIGGLIYVLVIEIHHPEPDSVFKAEQSEDKPEKYELSVIM

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
295

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
31401

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
7.95

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_5_Specific_Function:
Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea but not to glycerol

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00230:MIP

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
30-50
55-75
111-131
159-179
190-210
246-266

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
2887407

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
AQP9_HUMAN (O43315)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
AQP9

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
AQP9

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:643

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>888 bp
ATGCAGCCTGAGGGAGCAGAAAAGGGAAAAAGCTTCAAGCAGAGACTGGTCTTGAAGAGC
AGCTTAGCGAAAGAAACCCTCTCTGAGTTCTTGGGCACGTTCATCTTGATTGTCCTTGGA
TGTGGCTGTGTTGCCCAAGCTATTCTCAGTCGAGGACGTTTTGGAGGGGTCATCACTATC
AATGTTGGATTTTCAATGGCAGTTGCAATGGCCATTTATGTGGCTGGCGGTGTCTCTGGT
GGTCACATCAACCCAGCTGTGTCTTTAGCAATGTGTCTCTTTGGACGGATGAAATGGTTC
AAATTGCCATTTTATGTGGGAGCCCAGTTCTTGGGAGCCTTTGTGGGGGCTGCAACCGTC
TTTGGCATTTACTATGATGGACTTATGTCCTTTGCTGGTGGAAAACTGCTGATCGTGGGA
GAAAATGCAACAGCACACATTTTTGCAACATACCCAGCTCCGTATCTATCTCTGGCGAAC
GCATTTGCAGATCAAGTGGTGGCCACCATGATACTCCTCATAATCGTCTTTGCCATTTTT
GACTCCAGAAACTTGGGAGCCCCCAGAGGCCTAGAGCCCATTGCCATCGGCCTCCTGATT
ATTGTCATTGCTTCCTCCCTGGGACTGAACAGTGGCTGTGCCATGAACCCAGCTCGAGAC
CTGAGTCCCAGACTTTTCACTGCCTTGGCAGGCTGGGGGTTTGAAGTCTTCAGAGCTGGA
AACAACTTCTGGTGGATTCCTGTAGTGGGCCCTTTGGTTGGTGCTGTCATTGGAGGCCTC
ATCTATGTTCTTGTCATTGAAATCCACCATCCAGAGCCTGACTCAGTCTTTAAGGCAGAA
CAATCTGAGGACAAACCAGAGAAATATGAACTCAGTGTCATCATGTAG

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AB008775

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:15

# Macromolecular_Interacting_Partner_5_Locus:
15q22.1-22.2

# Macromolecular_Interacting_Partner_5_SNPs:
rs1867380; rs2249783; rs1001619; rs8024186; rs17240643; rs16939897; rs8043218; rs12899944; rs2899619; rs2414542; rs935208; rs2414544; rs1663248; rs935203; rs2414539; rs1711053; rs2899617; rs2414547; rs2414540; rs1711055; rs2414537; rs7179531; rs4775015; rs8042354; rs12594625; rs2414548; rs3858889; rs4511467; rs2292711; rs1663245; rs2007958; rs2414543; rs2280198; rs1618930; rs1814461; rs2292714; rs3784254; rs1663244; rs4775013; rs12441254; rs3858890; rs3742956; rs2292713; rs3784253; rs8035807; rs2414546; rs7165997; rs7167911; rs10444840; rs1317851; rs1874156; rs2271678; rs8042624; rs1980162; rs3784248; rs16939816; rs1663247; rs2280197; rs2292712; rs7178134; rs4775018; rs17240559; rs8023564; rs3784252; rs2414536; rs8040266; rs12440410; rs2063901; rs12437895; rs17821056; rs8024581; rs17821117; rs16953360; rs12903104; rs12441883; rs11854297; rs4775017; rs4775014; rs8037263; rs2414538; rs935206; rs16939839; rs935209; rs3825777; rs12899929; rs935207; rs11071369; rs2280195; rs1711057; rs12902853; rs8035112; rs2899618; rs935204; rs17821074; rs16939821; rs10518966; rs2414535; rs1992587; rs4544186; rs8023365; rs935202; rs17240566; rs7175669; rs2007738; rs13329178; rs11858796; rs2899616; rs7496568; rs8036397; rs8042608; rs4407009; rs8038241; rs1663246; rs1711054; rs1711056; rs12917145; rs12440784; rs17240552; rs16939822; rs16953363; rs8024969; rs8035676; rs8027681; rs11071370; rs8028649; rs11857438; rs17240573; rs2063902; rs17841969; rs2414545; rs4595742; rs8025123; rs7496709; rs10851634; rs17821086; rs16939881; rs3784255; rs17240580; rs12905045; rs16953358; rs7182601; rs8037406; rs8025133; rs1711058; rs4643260; rs7165818; rs1516400; rs3959686; rs9920853; rs8027250; rs1554203; rs17848098; rs35548603; rs28516056; rs34945403; rs1801806; rs17848108; rs17848093; rs1801805; rs35296260; rs34455921; rs34446605; rs3832977; rs28595548; rs3052067; rs34291701; rs12442737; rs34829124; rs34016844; rs935205; rs12441385; rs35752844; rs34019812; rs28368624; rs34487922; rs17848105; rs35701115; rs8030353; rs28537468; rs5812925; rs8027422; rs35924206; rs28654758; rs35140427; rs35600945; rs34000151; rs34687771; rs7174552; rs28568664; rs4774290; rs35085630; rs3985731; rs3742957; rs5812922; rs8030002; rs17848103; rs35699058; rs36115570; rs12903282; rs34451533; rs7180105; rs28495584; rs10638349; rs35105690; rs35963011; rs7181378; rs35546346; rs12591664; rs34326383; rs1711052; rs5812923; rs2280196; rs11296169; rs7174943; rs5812924; rs34090745; rs11431736; rs2704226; rs8030635; rs35137401; rs34715197; rs11318219; rs35537365; rs36093097; rs2414541; rs2453278; rs11629801; rs3742955; rs34246303; rs34034101; rs3840843; rs11636801; rs11639187; rs12050800; rs12440934; rs12906402; rs12909796; rs12913039; rs1615473; rs1663249; rs1663250; rs16939909; rs16939912; rs16939914; rs1711060; rs1711061; rs17240650; rs17571313; rs2077735; rs2077737; rs2642628; rs2642629; rs2704227; rs4775020; rs4775021; rs7161943; rs7162304; rs7173859; rs717868; rs7179233; rs7180019; rs8023369; rs8024274; rs8027554; rs8032339; rs8033742; rs9920375

# Macromolecular_Interacting_Partner_5_General_References:
9514918; 10564231

# Macromolecular_Interacting_Partner_5_References:
16154425

# Macromolecular_Interacting_Partner_6_ID:
8082

# Macromolecular_Interacting_Partner_6_Name:
Aquaporin-3

# Macromolecular_Interacting_Partner_6_Synonyms:
AQP-3

# Macromolecular_Interacting_Partner_6_Gene_Name:
AQP3

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Aquaporin3
MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTIN
LAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVF
GLYYDAIWHFADNQLFVSGPNGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVD
PYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQ
HWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENVKLAHVKHKEQI

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
292

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
31544

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
7.25

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_6_Specific_Function:
Forms a water-specific channel that provide kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. May function as a water and urea exit mechanism in antidiuresis in collecting duct cells. Also slightly permeable to urea and glycerol. May play an important role in gastrointestinal tract water transport and in glycerol metabolism

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00230:MIP

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
29-49
54-74
110-130
158-178
189-209
245-265

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
1854374

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
AQP3_HUMAN (Q92482)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
AQP3

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
AQP3

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:636

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Cell membrane; basolateral cell membrane; multi-pass membrane protein. Note=In collecting ducts of kidney

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>879 bp
ATGGGTCGACAGAAGGAGCTGGTGTCCCGCTGCGGGGAGATGCTCCACATCCGCTACCGG
TTGCTCCGACAGGCGCTGGCCGAGTGCCTGGGGACCCTCATCCTCGTGATGTTTGGCTGT
GGCTCCGTGGCCCAGGTTGTGCTCAGCCGGGGCACCCACGGTGGTTTCCTCACCATCAAC
CTGGCCTTTGGCTTTGCTGTCACTCTGGGCATCCTCATCGCTGGCCAGGTCTCTGGGGCC
CACCTGAACCCTGCCGTGACCTTTGCCATGTGCTTCCTGGCTCGTGAGCCCTGGATCAAG
CTGCCCATCTACACCCTGGCACAGACGCTGGGAGCCTTCTTGGGTGCTGGAATAGTTTTT
GGGCTGTATTATGATGCAATCTGGCACTTTGCCGACAACCAGCTTTTTGTTTCGGGCCCC
AATGGCACAGCCGGCATCTTTGCTACCTACCCCTCTGGACACTTGGATATGATCAATGGC
TTCTTTGACCAGTTCATAGGCACAGCCTCCCTTATCGTGTGTGTGCTGGCCATTGTTGAC
CCTTACAACAACCCCGTCCCCCGAGGCCTGGAGGCCTTCACCGTGGGCCTGGTGGTCCTG
GTCATTGGCACCTCCATGGGCTTCAACTCCGGCTATGCCGTCAACCCTGCCCGGGACTTT
GGCCCCCGCCTTTTTACAGCCCTTGCGGGCTGGGGCTCTGCAGTCTTCACGACCGGCCAG
CATTGGTGGTGGGTGCCCATCGTGTCCCCACTCCTGGGCTCCATTGCGGGTGTCTTCGTG
TACCAGCTGATGATCGGCTGCCACCTGGAGCAGCCCCCACCCTCCAACGAGGAAGAGAAT
GTGAAGCTGGCCCATGTGAAGCACAAGGAGCAGATCTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
AB001325

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_6_Locus:
9p13

# Macromolecular_Interacting_Partner_6_SNPs:
rs591810; rs2228332; rs16919255; rs12555686; rs17553719; rs10971513; rs2227285; rs2231227; rs10813981; rs17253713; rs2231231; rs517210; rs2231228; rs35198645; rs2231235; rs35910964; rs35806926; rs34391490; rs13301552; rs2231234; rs2231229; rs7847830; rs3860987; rs3758279; rs542976; rs35141650; rs12237858; rs2231225; rs35335069; rs34496252; rs35552135; rs567691; rs34944911; rs34837148; rs35787382; rs2231233; rs34942735; rs41306061; rs34552278; rs12378288; rs34738732; rs2231226; rs34707275; rs35786220; rs34927064; rs34830630; rs34782552; rs34850776; rs36085726; rs35437518; rs2231230; rs36051617; rs34151222; rs34111041; rs34617244; rs35125857; rs35881807; rs13289944; rs36038814; rs10738915; rs10758208; rs10813978; rs10813979; rs10813980; rs10813982; rs10971517; rs11787797; rs11793871; rs12554650; rs17253468; rs2380969; rs2777753; rs2777754; rs2989941; rs2992817; rs35252367; rs35809785; rs35998940; rs3758280; rs3849904; rs3860986; rs3892345; rs4284112; rs4559326; rs4879705; rs578351; rs583076; rs6476410; rs7030838; rs7031135; rs7033641; rs7854263; rs7858933

# Macromolecular_Interacting_Partner_6_General_References:
7558005; 12239222

# Macromolecular_Interacting_Partner_6_References:
16651733

# Macromolecular_Interacting_Partner_7_ID:
8717

# Macromolecular_Interacting_Partner_7_Name:
MGLL protein

# Macromolecular_Interacting_Partner_7_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Name:
MGLL

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>MGLL protein
METGPEDPSSMPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHG
AGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKD
YPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLV
LPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVP
FLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWV
SQRTATAGTASPP

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
313

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
34293

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.57

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  aromatic compound metabolism
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Lipid transport and metabolism

# Macromolecular_Interacting_Partner_7_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00561:Abhydrolase_1

# Macromolecular_Interacting_Partner_7_Signals:
Not Available

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
48145787

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
Q6IBG9_HUMAN (Q6IBG9)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
MGLL

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
MGLL

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:17038

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>942 bp
ATGGAAACAGGACCTGAAGACCCTTCCAGCATGCCAGAGGAAAGTTCCCCCAGGCGGACC
CCGCAGAGCATTCCCTACCAGGACCTCCCTCACCTGGTCAATGCAGACGGACAGTACCTC
TTCTGCAGGTACTGGAAACCCACAGGCACACCCAAGGCCCTCATCTTTGTGTCCCATGGA
GCCGGAGAGCACAGTGGCCGCTATGAAGAGCTGGCTCGGATGCTGATGGGGCTGGACCTG
CTGGTGTTCGCCCACGACCATGTTGGCCACGGACAGAGCGAAGGGGAGAGGATGGTAGTG
TCTGACTTCCACGTTTTCGTCAGGGATGTGTTGCAGCATGTGGATTCCATGCAGAAAGAC
TACCCTGGGCTTCCTGTCTTCCTTCTGGGCCACTCCATGGGAGGCGCCATCGCCATCCTC
ACGGCCGCAGAGAGGCCGGGCCACTTCGCCGGCATGGTACTCATTTCGCCTCTGGTTCTT
GCCAATCCTGAATCTGCAACAACTTTCAAGGTCCTTGCTGCGAAAGTGCTCAACCTTGTG
CTGCCAAACTTGTCCCTCGGGCCCATCGACTCCAGCGTGCTCTCTCGGAATAAGACAGAG
GTCGACATTTATAACTCAGACCCCCTGATCTGCCGGGCAGGGCTGAAGGTGTGCTTCGGC
ATCCAACTGCTGAATGCCGTCTCACGGGTGGAGCGCGCCCTCCCCAAGCTGACTGTGCCC
TTCCTGCTGCTCCAGGGCTCTGCCGATCGCCTGTGTGACAGCAAAGGGGCCTACCTGCTC
ATGGAGTTAGCCAAGAGCCAGGACAAGACTCTCAAGATTTATGAAGGTGCCTACCATGTT
CTCCACAAGGAGCTTCCTGAAGTCACCAACTCCGTCTTCCATGAAATAAACATGTGGGTC
TCTCAAAGGACAGCCACGGCAGGAACTGCGTCCCCACCTTAA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
CR456835

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_7_Locus:
3q21.3

# Macromolecular_Interacting_Partner_7_SNPs:
rs4881; rs9383; rs7578; rs782444; rs814130; rs3817477; rs814131; rs6439081; rs599287; rs627498; rs534018; rs605188; rs782441; rs803325; rs1437553; rs487369; rs2078637; rs567384; rs1721124; rs479504; rs782437; rs2630210; rs782449; rs541925; rs7652988; rs7653663; rs6439083; rs6772802; rs9759081; rs7648829; rs782440; rs477554; rs7651814; rs526862; rs11915484; rs782080; rs541042; rs600884; rs555183; rs6439082; rs11922836; rs10934819; rs482225; rs11715363; rs9869280; rs13076593; rs2276744; rs1474333; rs1474332; rs512726; rs7637101; rs684358; rs549662; rs7630666; rs484061; rs782436; rs9868912; rs597956; rs1466571; rs893294; rs9846048; rs608318; rs9289316; rs9882914; rs664910; rs587779; rs11925300; rs500104; rs9877819; rs629031; rs6801867; rs547801; rs7648815; rs3773146; rs664095; rs874546; rs13066225; rs16835913; rs664954; rs11917190; rs7615518; rs586919; rs11711929; rs3773159; rs573568; rs556125; rs7621379; rs541855; rs782443; rs3773160; rs782438; rs9825729; rs1437554; rs9757981; rs6787155; rs9289319; rs7635934; rs9877209; rs4974447; rs6778770; rs3773131; rs523925; rs7652615; rs16826716; rs616990; rs9842365; rs9842875; rs13323956; rs585887; rs10934820; rs10512693; rs507961; rs7650669; rs9830196; rs7645411; rs3773142; rs527719; rs6776142; rs17282181; rs16825943; rs11707342; rs7622033; rs12485988; rs621353; rs7634643; rs594323; rs1046821; rs1010174; rs11711251; rs16827188; rs3773154; rs529534; rs782082; rs812156; rs11713989; rs4974448; rs11924145; rs7637817; rs11924045; rs9811688; rs9289321; rs543797; rs3773155; rs586400; rs3773161; rs782295; rs3773137; rs2164754; rs17203666; rs1071912; rs4974449; rs2276745; rs7630461; rs522388; rs9289317; rs693742; rs6439084; rs782433; rs11916152; rs3773147; rs782081; rs6792534; rs6776002; rs9829976; rs11705710; rs6765071; rs2171131; rs3773139; rs9836225; rs561402; rs11709830; rs10512694; rs6791406; rs9860402; rs3732651; rs782434; rs2291372; rs9832418; rs16824401; rs12486711; rs9862130; rs7622377; rs796701; rs483193; rs3773135; rs2276743; rs11719045; rs520154; rs693430; rs4974414; rs7609914; rs6793064; rs6790303; rs7634912; rs688623; rs936839; rs9821704; rs7426633; rs12491505; rs7626899; rs17203659; rs497897; rs16824250; rs584886; rs7644343; rs16823666; rs9852837; rs782450; rs7648644; rs694605; rs7640849; rs471662; rs803059; rs11926105; rs16827117; rs9289320; rs16830397; rs4974415; rs654707; rs13077001; rs782451; rs11706801; rs11717519; rs483421; rs6780384; rs3773138; rs7653846; rs17203673; rs7651126; rs11713938; rs782442; rs9682719; rs604300; rs9823660; rs610795; rs6803366; rs497423; rs3773150; rs11923392; rs16830196; rs3773134; rs13088071; rs12496135; rs11927013; rs16833328; rs6769053; rs782439; rs782452; rs3821582; rs12106944; rs551080; rs6766626; rs13086586; rs7633484; rs16830415; rs11916129; rs3773130; rs481351; rs9856883; rs3773133; rs16825017; rs7631109; rs16835993; rs11719199; rs4974413; rs3821581; rs3773136; rs782445; rs2011138; rs11714763; rs9681081; rs6801421; rs6802526; rs1804711; rs11538700; rs11538698; rs34732369; rs12494477; rs34972627; rs12494528; rs11433015; rs12494533; rs34540434; rs7648804; rs11538699; rs6795640; rs1092128; rs34122388; rs28376787; rs10699515; rs7651012; rs36020109; rs34654963; rs9817523; rs35540950; rs9681464; rs34920427; rs11401380; rs35524851; rs34269884; rs10544371; rs11436982; rs1046820; rs35947819; rs35619448; rs10621235; rs34299476; rs9821239; rs3836353; rs13064150; rs35951289; rs35873899; rs6782885; rs34111506; rs13326079; rs28371855; rs640262; rs13093842; rs34642880; rs35849604; rs3773132; rs7644349; rs28788564; rs10658848; rs35698147; rs41266487; rs9756693; rs9838006; rs28437485; rs34024332; rs35030121; rs809146; rs28595573; rs34790184; rs35948688; rs36093560; rs34659988; rs28496522; rs35586493; rs34587739; rs11269771; rs6797454; rs16835977; rs34968677; rs3836352; rs28527810; rs35826853; rs36060051; rs488015; rs9835873; rs35425959; rs13066844; rs34032579; rs3836350; rs13319109; rs651647; rs9813280; rs5852523; rs13075440; rs35378345; rs3773153; rs35466537; rs35185550; rs11311000; rs7644821; rs28753886; rs13086452; rs6784225; rs4305384; rs5852522; rs34421818; rs35924738; rs9289318; rs34220827; rs10550786; rs10599059; rs7648162; rs10534334; rs13094409; rs35461972; rs10619970; rs34623730; rs9874425; rs35632623; rs35585592; rs34436210; rs11408673; rs6769254; rs10698665; rs35492886; rs35336500; rs34418127; rs35000374; rs6768816; rs3836351; rs4309675; rs35462403; rs4311178; rs34228116; rs35172754; rs3821588; rs35530155; rs34882202; rs10621920; rs35156008; rs478702; rs11923828; rs13093845; rs34884571; rs12632988; rs13084659; rs11428065; rs9881235; rs34240617; rs11294053; rs7646158; rs11342326; rs36232539; rs34709072; rs5852521; rs13071022; rs10563821; rs9867736; rs782435; rs11294169; rs10623100; rs36125403; rs35014000; rs11279104; rs35324977; rs7649495; rs513561; rs10619961; rs9860053; rs1723994; rs35724382; rs35180148; rs34730307; rs11359819; rs11281423; rs9836311; rs9828443; rs13434320; rs41266489; rs28536014; rs34036081; rs35813578; rs34147568; rs10676065; rs6800269; rs1658029; rs34417559; rs7648639; rs35691902; rs35649865; rs16830337; rs35307554; rs34420386; rs9821639; rs607371; rs9858317; rs35233574; rs35444871; rs35044959; rs34265860; rs11395995; rs10529338; rs35931736; rs34275876; rs7355992; rs35942309; rs13316160; rs28504174; rs11706522; rs35275665; rs34169294; rs28532288; rs11293851; rs34517374; rs7651925; rs35163155; rs11715987; rs35253940; rs7649891; rs35492059; rs34439985; rs5852520; rs9815888; rs34543777; rs7428322; rs34558173; rs12492826; rs34959726; rs1053246; rs1053253; rs1053254; rs11716997; rs12488138; rs1683659; rs2336408; rs5013467; rs6774667; rs6774938; rs6784336; rs6808043; rs713378; rs7610520; rs7632589; rs782446; rs782447; rs782448; rs782456; rs9917733

# Macromolecular_Interacting_Partner_7_General_References:
Not Available

# Macromolecular_Interacting_Partner_7_References:
Not Available

End of HMDB00131

Beginning of HMDB00132
# Accession_No:
HMDB00132

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-12 17:00:28

# biospider_lastupdate:
2007-08-02 12:58:11

# Common_Name:
Guanine

# Description:
Guanine is one of the five main nucleobases found in the nucleic acids DNA and RNA. Guanine is a derivative of purine, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Being unsaturated, the bicyclic molecule is planar. The guanine nucleoside is called guanosine. The first isolation of guanine was reported in 1844 from the excreta of sea birds, known as guano, which was used as a source of fertilizer. 
High affinity binding of guanine nucleotides and the ability to hydrolyze bound GTP to GDP are characteristics of an extended family of intracellular proteins. Guanine nucleotide-binding regulatory proteins may be involved in the activation of phospholipases C and A2 by hormones and other ligands. The binding of hormones to receptors that activate phospholipase C is decreased by guanine nucleotides and these hormones also stimulate a high-affinity GTPase activity in cell membranes. Effects of hormones on phospholipase C activity in cell-free preparations are dependent on the presence of guanine nucleotides.
Hypoxanthine-guanine phosphoribosyltransferase (HPRT, EC 2.4.2.8) is a purine salvage enzyme that catalyses the conversion of hypoxanthine and guanine to their respective mononucleotides. Partial deficiency of this enzyme can result in the overproduction of uric acid leading to a severe form of gout, whilst a virtual absence of HPRT activity causes the Lesch-Nyhan syndrome which is characterised by hyperuricaemia, mental retardation, choreoathetosis and compulsive self-mutilation.
Peroxynitrite induces DNA base damage predominantly at guanine (G) and 8-oxoguanine (8-oxoG) nucleobases via oxidation reactions. G and 8-oxoG are the most reactive bases toward Peroxynitrite and possibly the major contributors to peroxynitrite-derived genotoxic and mutagenic lesions. The neutral G radical,  reacts with NO2 to yield 8-nitroguanine and 5-nitro-4-guanidinohydantoin. (PMID: 16352449, 2435586, 2838362, 1487231)

# Synonyms:
GUN; Guanine enol; Guanine; Guanin; GUA;  Dew Pearl; CI Natural white 1; C.I. Natural White 1; 6-Hydroxy-2-aminopurine; 2-Aminohypoxanthine; 2-amino-Hypoxanthine; 2-Amino-6-purinol; 2-Amino-6-hydroxypurine; 2-Amino-6-hydroxy-1H-purine; 2-amino-3,7-dihydro-6H-purin-6-one; 2-Amino-1,9-dihydro-purin-6-one; 2-amino-1,9-dihydro-6H-purin-6-one; 2-amino-1,7-dihydro-6H-Purin-6-one; Stella Polaris; Pearl Essence; Pathocidin; Naturon; Natural White 1; Natural pearl essence; Mearlmaid AA; Mearlmaid

# Chemical_IUPAC_Name:
2-amino-3,7-dihydropurin-6-one

# Chemical_Formula:
C5H5N5O

# Chemical_Structure:
tbl_chemical:::HMDB00132_ZOOM.png:::119283208999956656

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00132_THUMB.png:::119283208840983036

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Pyrimidines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aromatic amine; oxo(het)arene; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
151.04941

# Molecular_Weight_Avg:
151.12611

# Smiles_String_isomeric:
NC1=NC(=O)C2=C(N1)N=CN2

# Smiles_String_canonical:
NC1=NC(=O)C2=C(N1)N=CN2

# KEGG_Compound_ID:
C00242

# BioCyc_ID:
GUANINE

# PubChem_CID:
764

# PubChem_SID:
3133367; 854375; 24895044; 594396; 819054; 25622228; 7888029; 7377195; 3541; 22390396; 834107; 7644358; 7004212; 2779; 16105542; 618937; 841460; 584550; 24697815; 24277513; 24697922; 855324; 1433762; 24697817; 836921; 24697819; 854934; 10534208; 149248; 16020045; 834960; 833698; 855322; 8150777; 24895050; 854953; 832638; 24895274; 7989359; 6184055; 585679; 8145637; 834957; 4963597; 25622131; 10420795; 24697820; 14891624; 14720110; 822946; 24697835; 11416826; 833362; 5161786; 4491989

# OMIM_ID:
608959; 610166; 240000; 139330; 190196; 605371; 605577; 176981; 146580; 604447; 608941; 608504; 139313; 189974; 139160; 600998; 609365; 604394; 139314; 603514; 139390; 139380; 139360; 610499; 143024; 609530; 604763; 606057; 606614; 604406; 606058; 601982; 607954; 604397; 139180; 600888; 601619; 610863; 604430; 605991; 139340; 600874; 605477; 300429; 300267; 609615; 600358; 606600; 139391; 605216; 601855; 300322; 609700; 606981; 604388; 139320; 139312; 139311; 189970; 607298; 608136; 605708; 604390; 139130; 610215; 607274; 606051; 139370; 609527; 156569; 139310; 610778; 308000; 130592; 603417; 607560; 605882; 605667; 604141; 600303; 300323; 608011; 604389; 182530; 603655; 139260

# Metagene_ID:
48

# BiGG_ID:
34363

# Wikipedia_ID:
Guanine

# METLIN_ID:
315

# Ref_ID:
2546548; 3062020; 7614924; 3939543; 15908587; 12829005; 8930907; 7677251; 8605156; 8241644; 1727385; 2927433; 12088208; 12028120; 11788733

# ChEBI_ID:
16235

# CAS_Registry_Number:
73-40-5

# InChI:
InChI=1/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)

# Synthesis_Reference:
New syntheses of xanthine, caffeine, and theobromine.     Bredereck, Hellmut; Schuh, Heinzgeorg v.; Martini, Anneliese.    Tech. Hochschule,  Stuttgart,  Germany.    Chemische Berichte  (1950),  83  201-11.

# Melting_Point:
360 oC

# Melting_Point_predicted:
123.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
2.08 mg/mL at 37 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
2.31 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-0.91 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-0.9 [Predicted by PubChem via XLOGP]; -0.92 [Predicted by ALOGPS]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Guanine.pdf:::1132562204195808765

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00132.mol:::118608109439060241

# SDF_File_[Text]:
tbl_chemical:::HMDB00132.sdf:::119283208528996255

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00132.pdb:::119283208702910508

# PDB_ID:
1A95

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041024_P00_03_HW_2DHSQC_63.jpg:::114780757591492940

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041024_P00_03_HW_2DHSQC_63.zip:::114780757601235325

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041024_P00_03_HW_2DHSQC_63_Assigned.jpg:::115384195571731744

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Guanine.gif:::1132732112328816755

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00132_peaks.txt:::1156309566858692274

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Guanine_C.gif:::1132737694581813407

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00132_peaks.txt:::1156310756842447635

# Mass_Spectrum:
tbl_chemical:::cbook.cgi.gif:::114672889067441586

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000090.png:::116890826429625016

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000090.txt:::116890826456275893

# Cellular_Location:
Cytoplasm (Predicted from LogP); Extracellular

# Tissue_Location:
Epidermis; Fibroblasts; Intestine; Muscle; Myelin; Neurons; Prostate; Spleen; Testis

# deuterated:
No

# Biofluid_Location:
Cellular Cytoplasm; Urine

# Concentration_[Normal]:
Urine	0.37 (0.18-0.57)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	12829005
Cellular_Cytoplasm	97	uM	Adult:>18_yrs_old	Both	Normal	3939543


# Concentration_[Abnormal]:
Urine	1.92 (0.99-2.86)	umol/mmol_creatinine	N/A	Both		12829005


# Associated_Disorders:
Friedreich's Ataxia; Heterotopia; Lesch-Nyhan Syndrome

# Pathway_Names:
Purine metabolism

# Pathway_Images:
Purine_Synthesis.jpg

# KEGG_Images:
map00230

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg

# Pathway_SBMLs:
Purine_Synthesis.xml

# Metabolic_Enzyme_1_ID:
6122

# Metabolic_Enzyme_1_Name:
4-hydroxyphenylpyruvate dioxygenase

# Metabolic_Enzyme_1_Synonyms:
4HPPD; HPD; HPPDase; 4-hydroxyphenylpyruvic acid oxidase

# Metabolic_Enzyme_1_Gene_Name:
HPD

# Metabolic_Enzyme_1_Protein_Sequence:
>4hydroxyphenylpyruvate dioxygenase
MTTYSDKGAKPERGRFLHFHSVTFWVGNAKQAASFYCSKMGFEPLAYRGLETGSREVVSH
VIKQGKIVFV
LSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAKIMR
EPWVEQDKFGKVKFAVLQTYG
DTTHTLVEKMNYIGQFLPGYEAPAFMDPLLPKLPKCSL
EMIDHIVGNQPDQEMVSASEWYLKNLQFHRFW
SVDDTQVHTEYSSLRSIVVANYEESIK
MPINEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRH
LRERGLEFLSVPSTYY
KQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIFTKPVQDRPTLFLEV
IQRHN
HQGFGAGNFNSLFKAFEEEQNLRGNLTNMETNGVVPGM

# Metabolic_Enzyme_1_Number_of_Residues:
393

# Metabolic_Enzyme_1_Molecular_Weight:
44935

# Metabolic_Enzyme_1_Theoretical_pI:
7.01

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
Function:  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Function:  4-hydroxyphenylpyruvate dioxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
4-hydroxyphenylpyruvate + O(2) = homogentisate + CO(2)

# Metabolic_Enzyme_1_Pathway:
map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_1_Reaction:
4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00903:Glyoxalase

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.13.11.27

# Metabolic_Enzyme_1_GenBank_ID_Protein:
3860238

# Metabolic_Enzyme_1_SwissProt_ID:
HPPD_HUMAN (P32754)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
HPD

# Metabolic_Enzyme_1_Geneatlas_id:
HPD

# Metabolic_Enzyme_1_hgnc_id:
HGNC:5147

# Metabolic_Enzyme_1_PDB_ID:
1SQI

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1182 bp

ATGACGACTTACAGTGACAAAGGGGCAAAGCCTGAGAGAGGCCGATTCCTCCACTTCCA
CTCTGTGACCT
TCTGGGTTGGCAACGCCAAGCAGGCCGCGTCATTCTACTGCAGCAAGA
TGGGCTTTGAACCTCTAGCCTA
CAGGGGCCTGGAGACCGGTTCCCGGGAGGTGGTCAGC
CATGTAATCAAACAAGGGAAGATTGTGTTTGTC
CTCTCCTCAGCGCTCAACCCCTGGAA
CAAAGAGATGGGCGATCACCTGGTGAAACACGGTGACGGAGTGA
AGGACATTGCGTTCG
AGGTGGAAGATTGTGACTACATCGTGCAGAAAGCACGGGAACGGGGCGCCAAAAT
CATG
CGGGAGCCCTGGGTAGAGCAAGACAAGTTTGGGAAGGTGAAGTTTGCTGTGCTGCAGACG
TATGGG
GACACCACACACACCCTGGTGGAGAAGATGAACTACATCGGCCAATTCTTGCC
TGGATATGAGCCCCCAG
CGTTCATGGACCCCCTACTTCCTAAACTGCCCAAATGCAGTC
TGGAGATGATCGACCACATTGTGGGAAA
CCAGCCTGATCAGGAGATGGTGTCCGCCTCC
GAATGGTACCTGAAAAACCTGCAGTTCCACCGCTTCTGG
TCCGTGGATGACACGCAGGT
GCACACGGAATATAGCTCTCTGCGATCCATTGTGGTGGCCAACTATGAAG
AGTCCATCA
AGATGCCCATCAATGAGCCAGCGCCTGGCAAGAAGAAGTCCCAGATCCAGGAATATGTGG
A
CTATAACGGGGGCGCTGGGGTCCAGCACATCGCTCTCAAGACCGAAGACATCATCACA
GCGATTCGCCAC
TTGAGAGAGAGAGGCCTGGAGTTCTTATCTGTTCCCTCCACGTACTA
CAAACAACTGCGGGAGAAGCTGA
AGACGGCCAAGATCAAGGTGAAGGAGAACATTGATG
CCCTGGAGGAGCTGAAAATCCTGGTGGACTACGA
CGAGAAAGGCTACCTCCTGCAGATC
TTCACCAAACCGGTGCAGGACCGGCCCACGCTCTTCCTGGAAGTC
ATCCAGCGCCACAA
CCACCAGGGTTTTGGAGCCGGCAACTTCAACTCACTGTTCAAGGCTTTCGAGGAGG
AGC
AGAACCTGCGGGGTAACCTCACCAACATGGAGACCAATGGGGTGGTGCCCGGCATGTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U29895

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_1_Locus:
12q24-qter

# Metabolic_Enzyme_1_SNPs:
rs1154510; rs11833399; rs36023382; rs2247291; rs1449562; rs2596140; rs1610041; rs2515729; rs1795963; rs4760102; rs3741587; rs2620334; rs2707072; rs3741586; rs2707056; rs10840622; rs11043214; rs2707070; rs12310752; rs2620340; rs2707055; rs2707075; rs10840623; rs3832816; rs2707058; rs4760103; rs11043217; rs11043213; rs11613865; rs11043216; rs2620339; rs2620332; rs4760105; rs1154515; rs2596144; rs2596143; rs4298948; rs3741591; rs11043218; rs10840619; rs2596142; rs35115987; rs2596139; rs35849100; rs1801436; rs1126925; rs1042843; rs1042844; rs2707063; rs2620354; rs2620333; rs12830647; rs1154512; rs2707074; rs2855415; rs35794561; rs35616764; rs2442440; rs4516009; rs2515730; rs2620350; rs12580755; rs12372468; rs2596145; rs2620337; rs12313193; rs28711529; rs1154516; rs1154511; rs4439557; rs35705173; rs11043212; rs1894285; rs2596141; rs2707054; rs35476559; rs35131803; rs2620347; rs2620349; rs12820413; rs35384269; rs2707071; rs35232597; rs2620338; rs35599566; rs34943778; rs11043211; rs35849071; rs12830638; rs35556469; rs12821095; rs9668731; rs2515731; rs2620335; rs2620346; rs35712089; rs2859577; rs2620348; rs2596138; rs35593190; rs1183890; rs12825630; rs12826129; rs10600651; rs11043210; rs12299502; rs2442441; rs2855414; rs2448483; rs11043215; rs2620336; rs35633723; rs2620341; rs34879391; rs3970383; rs2707057; rs2596146; rs2707073; rs2707062; rs34360786; rs35870123; rs34073901; rs11043219; rs35359220; rs34777671; rs11395265; rs35918033; rs12822028; rs33973864; rs5801455; rs36096665; rs34042138; rs10840624; rs11043207; rs11043222; rs11043223; rs11614326; rs12316702; rs12823194; rs9668191

# Metabolic_Enzyme_1_General_References:
8504803; 7851880; 8521727; 10942115; 11073718

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6123

# Metabolic_Enzyme_2_Name:
Homogentisate 1,2-dioxygenase

# Metabolic_Enzyme_2_Synonyms:
Homogentisicase; Homogentisate oxygenase; Homogentisic acid oxidase

# Metabolic_Enzyme_2_Gene_Name:
HGD

# Metabolic_Enzyme_2_Protein_Sequence:
>Homogentisate 1,2dioxygenase
MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW
LYRILPSVSHKPFESIDEGHVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC
GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC
VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP
GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV
LTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPG
GGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKWGLKASRCLD
ENYHKCWEPLKSHFTPNSRNPAEPN

# Metabolic_Enzyme_2_Number_of_Residues:
445

# Metabolic_Enzyme_2_Molecular_Weight:
49973

# Metabolic_Enzyme_2_Theoretical_pI:
7.00

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
Function:  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Function:  homogentisate 1,2-dioxygenase activity
 ||
>>>
Process:  tyrosine metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
Process:  L-phenylalanine metabolism
Process:  L-phenylalanine catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_2_Specific_Function:
Homogentisate + O(2) = 4-maleylacetoacetate

# Metabolic_Enzyme_2_Pathway:
map00350  Tyrosine metabolism;
 map00643  Styrene degradation

# Metabolic_Enzyme_2_Reaction:
homogentisate + O2 = 4-maleylacetoacetate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF04209:HgmA

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.13.11.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1616743

# Metabolic_Enzyme_2_SwissProt_ID:
HGD_HUMAN (Q93099)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
HGD

# Metabolic_Enzyme_2_Geneatlas_id:
HGD

# Metabolic_Enzyme_2_hgnc_id:
HGNC:4892

# Metabolic_Enzyme_2_PDB_ID:
1EYB

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>1338 bp
ATGGCTGAGTTAAAGTACATTTCTGGATTTGGGAATGAGTGTTCTTCAGAGGATCCTCGC
TGCCCAGGTTCCCTGCCAGAAGGACAGAATAATCCTCAGGTCTGCCCCTACAATCTCTAT
GCTGAGCAGCTCTCAGGATCGGCTTTCACTTGTCCACGGAGCACCAATAAGAGAAGCTGG
CTGTATAGGATTCTACCTTCAGTTTCTCACAAGCCCTTTGAATCCATTGACGAAGGCCAT
GTCACTCACAACTGGGATGAAGTTGATCCTGATCCTAACCAGCTTAGATGGAAACCATTT
GAGATTCCAAAAGCATCTCAGAAGAAAGTAGACTTTGTGAGTGGCCTGCATACCTTGTGT
GGAGCTGGAGACATAAAGTCTAACAATGGGCTTGCTATCCACATTTTCCTCTGCAATACC
TCCATGGAGAACAGATGCTTTTACAATTCAGATGGGGACTTCTTGATTGTTCCGCAGAAA
GGGAACCTTCTCATTTACACCGAGTTTGGCAAGATGCTTGTACAGCCCAATGAGATCTGC
GTCATTCAGAGAGGAATGCGGTTCAGCATAGATGTCTTTGAGGAGACCAGGGGCTACATC
TTGGAGGTCTATGGTGTCCACTTTGAGTTACCTGACCTTGGACCAATTGGGGCCAATGGC
TTGGCCAATCCTCGTGATTTCTTGATACCCATTGCCTGGTATGAGGATCGCCAAGTACCA
GGTGGTTACACGGTCATTAATAAATACCAGGGCAAGCTGTTTGCTGCCAAACAGGATGTC
TCCCCGTTCAATGTTGTGGCCTGGCACGGGAATTATACACCCTACAAGTACAACCTGAAG
AATTTCATGGTTATCAACTCAGTGGCCTTTGACCATGCAGACCCATCCATTTTCACAGTA
TTGACTGCTAAGTCTGTCCGCCCTGGAGTGGCCATTGCTGATTTTGTCATCTTCCCACCT
CGATGGGGGGTTGCTGATAAGACCTTCAGGCCTCCTTATTACCATAGGAACTGCATGAGT
GAGTTCATGGGACTCATCCGAGGTCACTATGAGGCAAAGCAAGGTGGGTTCCTGCCAGGG
GGAGGGAGTCTACACAGCACAATGACCCCCCATGGACCTGATGCTGACTGCTTTGAGAAG
GCCAGCAAGGTCAAGCTGGCACCTGAGAGGATTGCCGATGGCACCATGGCATTTATGTTT
GAATCATCTTTAAGTCTGGCGGTCACAAAGTGGGGACTCAAGGCCTCCAGGTGTTTGGAT
GAGAACTACCACAAGTGCTGGGAGCCACTCAAGAGCCACTTCACTCCCAACTCCAGGAAC
CCAGCAGAACCTAATTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
U63008

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_2_Locus:
3q13.33

# Metabolic_Enzyme_2_SNPs:
rs6801568; rs1862936; rs2320009; rs6802241; rs6801736; rs2320008; rs804978; rs34381219; rs34693246; rs6801384; rs6776950; rs34093167; rs34085626; rs41473548; rs1800722; rs1800700; rs41452145; rs804979; rs6797727

# Metabolic_Enzyme_2_General_References:
8782815; 9244427; 10876237; 9154114; 9529363; 9630082; 10205262; 10340975; 10482952; 10594001

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5715

# Metabolic_Enzyme_3_Name:
Hypoxanthine-guanine phosphoribosyltransferase

# Metabolic_Enzyme_3_Synonyms:
HGPRT; HGPRTase

# Metabolic_Enzyme_3_Gene_Name:
HPRT1

# Metabolic_Enzyme_3_Protein_Sequence:
>Hypoxanthineguanine phosphoribosyltransferase
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA

# Metabolic_Enzyme_3_Number_of_Residues:
218

# Metabolic_Enzyme_3_Molecular_Weight:
24580

# Metabolic_Enzyme_3_Theoretical_pI:
6.67

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
Function:  hypoxanthine phosphoribosyltransferase activity
 ||
>>>
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  purine salvage
Process:  purine ribonucleoside salvage
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_3_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
IMP + diphosphate = hypoxanthine + 5-phospho- alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_3_Reaction:
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00156:Pribosyltran

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.4.2.8

# Metabolic_Enzyme_3_GenBank_ID_Protein:
306885

# Metabolic_Enzyme_3_SwissProt_ID:
HPRT_HUMAN (P00492)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
HPRT1

# Metabolic_Enzyme_3_Geneatlas_id:
HPRT1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:5157

# Metabolic_Enzyme_3_PDB_ID:
1BZY

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>657 bp
ATGGCGACCCGCAGCCCTGGCGTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGAT
TTATTTTGCATACCTAATCATTATGCTGAGGATTTGGAAAGGGTGTTTATTCCTCATGGA
CTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCAT
CACATTGTAGCCCTCTGTGTGCTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGAT
TACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACTGTAGATTTTATC
AGACTGAAGAGCTATTGTAATGACCAGTCAACAGGGGACATAAAAGTAATTGGTGGAGAT
GATCTCTCAACTTTAACTGGAAAGAATGTCTTGATTGTGGAAGATATAATTGACACTGGC
AAAACAATGCAGACTTTGCTTTCCTTGGTCAGGCAGTATAATCCAAAGATGGTCAAGGTC
GCAAGCTTGCTGGTGAAAAGGACCCCACGAAGTGTTGGATATAAGCCAGACTTTGTTGGA
TTTGAAATTCCAGACAAGTTTGTTGTAGGATATGCCCTTGACTATAATGAATACTTCAGG
GATTTGAATCATGTTTGTGTCATTAGTGAAACTGGAAAAGCAAAATACAAAGCCTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M31642

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_3_Locus:
Xq26.1

# Metabolic_Enzyme_3_SNPs:
rs17882614; rs17324664; rs1468266; rs6638240; rs6638244; rs629; rs12687175; rs2070888; rs17882706; rs17879768; rs6638243; rs6634993; rs2283774; rs2515695; rs17324671; rs17000619; rs17879343; rs17881098; rs17883992; rs17882148; rs6634992; rs17885981; rs17879832; rs17879883; rs17882974; rs17879054; rs6654281; rs17885745; rs17878776; rs17885116; rs17882408; rs17883944; rs17879655; rs17879788; rs17885487; rs17879062; rs12383909; rs17882655; rs6638248; rs17879889; rs6638241; rs17880246; rs17879587; rs12008402; rs17885587; rs17879537; rs17885351; rs17879338; rs17886003; rs17884897; rs17879126; rs17884671; rs17878519; rs17885249; rs17878726; rs17882575; rs630; rs17879579; rs17885481; rs17882577; rs17882724; rs17880173; rs17882449; rs17878366; rs17883719; rs17882059; rs17885063; rs17878341; rs17885117; rs17882713; rs17882954; rs17878494; rs17882387; rs17879006; rs17886404; rs17879389; rs17885867; rs17883942; rs17878843; rs17885455; rs17882760; rs17884775; rs6634990; rs6634995; rs17878582; rs17878883; rs17882358; rs17879110; rs17881011; rs35095771; rs41299094; rs17879494; rs17878772; rs11369747; rs12839009; rs17880167; rs17882944; rs17881023; rs374290; rs35009311; rs17883755; rs12861067; rs17882363; rs34425749; rs34838035; rs366687; rs6638242; rs17879610; rs28478865; rs17887208; rs405630; rs12380958; rs5903878; rs17878547; rs35869442; rs387714; rs35585686; rs6634994; rs17882487; rs17879085; rs5978009; rs5933415; rs17883196; rs116493; rs5933416; rs12836923; rs12381664; rs35238558; rs17882186; rs373901; rs35653185; rs17881003; rs6638245; rs35325865; rs35834777; rs11406107; rs17884978; rs17885259; rs17882884; rs17883708; rs12836918; rs391918; rs34619253; rs377106; rs35538011; rs17884910; rs398712; rs5933414; rs35832135; rs17885490; rs12381784; rs377103; rs5903877; rs17880051; rs12838998; rs17878536; rs11344152; rs2503983; rs36109224; rs17884854; rs17878792; rs17878589; rs7472760; rs28663133; rs117407; rs17881034; rs12381662; rs17886030; rs6638246; rs17885101; rs17879848; rs17879532; rs17882283; rs417522; rs17878403; rs414365; rs5978007; rs398716; rs7357883; rs10482430; rs12689866; rs12847109; rs437849; rs4829768; rs6634997; rs6638238

# Metabolic_Enzyme_3_General_References:
6300847; 2341149; 7107641; 3023844; 8044844; 10360366; 10338013; 1487231; 6853490; 6853716; 6572373; 6706936; 3358423; 3384338; 3265398; 2896620; 3198771; 3148064; 2572141; 2909537; 2910902; 2738157; 2928313; 2347587; 2358296; 2246854; 2018042; 2071157; 1937471; 1840476; 1551676; 1301916; 7627191; 9003484; 9452051

# Metabolic_Enzyme_3_References:
16038590; 16293269; 16395695; 16612037

# Macromolecular_Interacting_Partner_1_ID:
7546

# Macromolecular_Interacting_Partner_1_Name:
Prolactin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
PRL

# Macromolecular_Interacting_Partner_1_Gene_Name:
PRL

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Prolactin precursor
MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN
EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG
LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
227

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
25876

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.99

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Prolactin acts primarily on the mammary gland by promoting lactation

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_1_Signals:
1-28

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
34211

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
PRL_HUMAN (P01236)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
PRL

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
PRL

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9445

# Macromolecular_Interacting_Partner_1_PDB_ID:
1RW5

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>684 bp
ATGAACATCAAAGGATCGCCATGGAAAGGGTCCCTCCTGCTGCTGCTGGTGTCAAACCTG
CTGCTGTGCCAGAGCGTGGCCCCCTTGCCCATCTGTCCCGGCGGGGCTGCCCGATGCCAG
GTGACCCTTCGAGACCTGTTTGACCGCGCCGTCGTCCTGTCCCACTACATCCATAACCTC
TCCTCAGAAATGTTCAGCGAATTCGATAAACGGTATACCCATGGCCGGGGGTTCATTACC
AAGGCCATCAACAGCTGCCACACTTCTTCCCTTGCCACCCCCGAAGACAAGGAGCAAGCC
CAACAGATGAATCAAAAAGACTTTCTGAGCCTGATAGTCAGCATATTGCGATCCTGGAAT
GAGCCTCTGTATCATCTGGTCACGGAAGTACGTGGTATGCAAGAAGCCCCGGAGGCTATC
CTATCCAAAGCTGTAGAGATTGAGGAGCAAACCAAACGGCTTCTAGAGGGCATGGAGCTG
ATAGTCAGCCAGGTTCATCCTGAAACCAAAGAAAATGAGATCTACCCTGTCTGGTCGGGA
CTTCCATCCCTGCAGATGGCTGATGAAGAGTCTCGCCTTTCTGCTTATTATAACCTGCTC
CACTGCCTACGCAGGGATTCACATAAAATCGACAATTATCTCAAGCTCCTGAAGTGCCGA
ATCATCCACAACAACAACTGCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00566

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_1_Locus:
6p22.2-p21.3

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
6260780; 6325171; 2050267; 6146607; 9266104; 925136; 1126929

# Macromolecular_Interacting_Partner_1_References:
15977802

# Macromolecular_Interacting_Partner_2_ID:
7487

# Macromolecular_Interacting_Partner_2_Name:
Methylated-DNA--protein-cysteine methyltransferase

# Macromolecular_Interacting_Partner_2_Synonyms:
6-O- methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA- alkyltransferase

# Macromolecular_Interacting_Partner_2_Gene_Name:
MGMT

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>MethylatedDNAproteincysteine methyltransferase
MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLM
QCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAAL
AGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPG
LGGSSGLAGAWLKGAGATSGSPPAGRN

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
207

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
21646

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
8.23

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  methylated-DNA-[protein]-cysteine S-methyltransferase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  S-methyltransferase activity
Function:  methylated-DNA-[protein]-cysteine S-methyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  DNA metabolism
Process:  DNA repair
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Replication, recombination and repair 

# Macromolecular_Interacting_Partner_2_Specific_Function:
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction:the enzyme is irreversibly inactivated

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF01035:DNA_binding_1;
PF02870:Methyltransf_1N

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
EC 2.1.1.63

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
34559

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
MGMT_HUMAN (P16455)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
MGMT

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
MGMT

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:7059

# Macromolecular_Interacting_Partner_2_PDB_ID:
1EH6

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>624 bp
ATGGACAAGGATTGTGAAATGAAACGCACCACACTGGACAGCCCTTTGGGGAAGCTGGAG
CTGTCTGGTTGTGAGCAGGGTCTGCACGAAATAAAGCTCCTGGGCAAGGGGACGTCTGCA
GCTGATGCCGTGGAGGTCCCAGCCCCCGCTGCGGTTCTCGGAGGTCCGGAGCCCCTGATG
CAGTGCACAGCCTGGCTGAATGCCTATTTCCACCAGCCCGAGGCTATCGAAGAGTTCCCC
GTGCCGGCACTTCACCATCCCGTTTTCCAGCAAGAGTCGTTCACCAGACAGGTGTTATGG
AAGCTGCTGAAGGTTGTGAAATTCGGAGAAGTGATTTCTTACCAGCAATTAGCAGCCCTG
GCAGGCAACCCCAAAGCCGCGCGAGCAGTGGGAGGAGCAATGAGAGGCAATCCTGTCCCC
ATCCTCATCCCGTGCCACAGAGTGGTCTGCAGCAGCGGAGCCGTGGGCAACTACTCCGGA
GGACTGGCCGTGAAGGAATGGCTTCTGGCCCATGAAGGCCACCGGTTGGGGAAGCCAGGC
TTGGGAGGGAGCTCAGGTCTGGCAGGGGCCTGGCTCAAGGGAGCGGGAGCTACCTCGGGC
TCCCCGCCTGCTGGCCGAAACTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
X54228

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_2_Locus:
10q26

# Macromolecular_Interacting_Partner_2_SNPs:
rs2020893; rs2308321; rs2282164; rs2308320; rs2308327; rs12917; rs2308318; rs1803965; rs2308319; rs2308324; rs10741191; rs1762419; rs945231; rs2027137; rs7095030; rs1762428; rs7910339; rs7477105; rs1762421; rs1762418; rs1762426; rs4751094; rs7076950; rs6482740; rs7094710; rs2388332; rs1711669; rs11813056; rs871028; rs2152151; rs1762417; rs871026; rs1711662; rs945222; rs3802689; rs871029; rs10764888; rs12268726; rs1537686; rs12242312; rs1537688; rs10741193; rs1762430; rs12254786; rs12256564; rs10741190; rs12412984; rs12573709; rs2388331; rs7079768; rs9299870; rs7075505; rs11813530; rs1771432; rs871027; rs11016820; rs1537691; rs10829601; rs7087541; rs11016811; rs7923733; rs10764883; rs7070347; rs880301; rs2027136; rs10829600; rs4750755; rs3802691; rs11591545; rs1711670; rs12254582; rs9299871; rs7087434; rs7089777; rs7902058; rs880300; rs10764882; rs10741194; rs12259379; rs1771448; rs7918153; rs10829599; rs947082; rs10741195; rs12257108; rs1711650; rs12240584; rs7097774; rs11016823; rs11596574; rs1123226; rs7913859; rs7098519; rs11016831; rs7095425; rs12248737; rs12573708; rs12249421; rs1762429; rs12258707; rs1711654; rs12761840; rs12243120; rs12240470; rs7083508; rs12258668; rs12256432; rs12258673; rs7094745; rs12256911; rs12252212; rs12264468; rs4751087; rs6482741; rs7903489; rs12242588; rs12247004; rs7913966; rs16906252; rs12264367; rs3802690; rs1762431; rs11814637; rs7073801; rs7087241; rs12247145; rs12262382; rs4751095; rs1762425; rs12254008; rs11818404; rs7097622; rs12260001; rs2388330; rs12784489; rs7070957; rs1711663; rs4750754; rs7900620; rs1711668; rs10829598; rs11812668; rs945224; rs11016816; rs7087375; rs7894603; rs10829604; rs11016830; rs11016833; rs10829602; rs12248682; rs12762266; rs12776412; rs12266768; rs4751091; rs1618593; rs12246239; rs12248342; rs7081621; rs1711667; rs12249593; rs12256667; rs7075213; rs1762433; rs7098568; rs11818082; rs7096528; rs12356501; rs7073057; rs11016813; rs12764733; rs12766854; rs12256491; rs7080949; rs10764885; rs2152150; rs10741192; rs12260271; rs12769288; rs7069693; rs10764887; rs12241333; rs7913096; rs4751088; rs7917258; rs1631420; rs11598131; rs7903089; rs12784269; rs11016815; rs7920419; rs2027139; rs12250672; rs12264394; rs7075207; rs11592093; rs12262890; rs9663501; rs4751089; rs12251863; rs11016810; rs12761694; rs12250054; rs7924127; rs2027138; rs11016817; rs7098627; rs10829603; rs12260472; rs7069786; rs7920272; rs10764884; rs12777580; rs7903069; rs1762423; rs12243040; rs1762427; rs4750751; rs7922772; rs12256817; rs12776587; rs1771433; rs1711661; rs1711674; rs12269253; rs11016821; rs7098210; rs12265555; rs12251275; rs12268651; rs1631355; rs12266534; rs12261364; rs12269104; rs11815619; rs12247341; rs10764886; rs7098619; rs4751109; rs4751102; rs693402; rs7910123; rs544217; rs4145857; rs989097; rs2053139; rs558764; rs748190; rs6482748; rs7080570; rs516704; rs7101247; rs4751099; rs576560; rs879281; rs2282163; rs554458; rs7096238; rs989095; rs12708322; rs483959; rs7095819; rs477692; rs509041; rs546333; rs532248; rs7084824; rs7894836; rs7080419; rs6482753; rs522891; rs4750761; rs1980849; rs4750760; rs574831; rs2039373; rs3829194; rs1434744; rs7898151; rs1978759; rs7916804; rs3793906; rs892659; rs524545; rs748189; rs4751100; rs548390; rs552551; rs551491; rs7087783; rs4751107; rs2094291; rs6482743; rs569235; rs1359705; rs508303; rs879280; rs10829620; rs913117; rs576175; rs7069462; rs508360; rs6482749; rs11592158; rs7916547; rs1033983; rs6482742; rs4751108; rs489966; rs4750759; rs913119; rs3852507; rs7922405; rs511361; rs1970197; rs7920731; rs506915; rs7898934; rs2026976; rs577227; rs4751115; rs531572; rs506274; rs7909391; rs6482747; rs2053138; rs6482750; rs496298; rs4750757; rs2150920; rs4751101; rs507900; rs530466; rs556253; rs2388443; rs570967; rs4751118; rs1359704; rs3793907; rs502076; rs475250; rs4751113; rs989096; rs3858300; rs7079744; rs10829622; rs6482752; rs4751106; rs1359706; rs4751112; rs579952; rs6482744; rs513736; rs514963; rs7075249; rs7080548; rs7078706; rs1537257; rs555545; rs913118; rs2039374; rs1978758; rs7071825; rs3829195; rs471390; rs524804; rs578932; rs538969; rs11816923; rs7087131; rs2183878; rs511770; rs10764899; rs4986982; rs10829621; rs7086923; rs567700; rs7085289; rs519690; rs12266634; rs7068306; rs10829619; rs11593531; rs512655; rs473073; rs10829610; rs2008387; rs12219068; rs11016885; rs6482751; rs4750766; rs480643; rs7082319; rs9299872; rs554792; rs7916932; rs11016862; rs7092285; rs7923750; rs10829605; rs488143; rs7073892; rs3793908; rs11016883; rs12220901; rs4750763; rs7081359; rs11817222; rs7897876; rs534430; rs4751114; rs10741199; rs12264213; rs7099068; rs10741198; rs3915924; rs528549; rs7475154; rs751133; rs3793911; rs509017; rs12256428; rs513074; rs6482754; rs12413023; rs6482745; rs543454; rs11592922; rs553371; rs473771; rs11812599; rs7073225; rs7069414; rs2308328; rs10829614; rs12570784; rs2282165; rs9971190; rs11016875; rs12250002; rs12219729; rs10829611; rs877184; rs11813363; rs3793912; rs11016881; rs12247555; rs4751111; rs7098548; rs12573548; rs7075748; rs12248450; rs7097039; rs11592693; rs7901876; rs7921260; rs479478; rs11016844; rs12412853; rs7917453; rs4750764; rs11016877; rs545207; rs11813468; rs12412086; rs555020; rs1111050; rs7095917; rs7904404; rs540992; rs10829618; rs7907239; rs1078847; rs7076288; rs7098295; rs11016897; rs7917977; rs12412879; rs3793909; rs10764893; rs2296675; rs496692; rs11816055; rs503660; rs7905095; rs7091540; rs945226; rs10764896; rs10829616; rs4750765; rs12414065; rs565974; rs12248703; rs10829626; rs11594558; rs10764901; rs4750768; rs11593181; rs11016857; rs10764900; rs2026975; rs7068301; rs7093369; rs10829615; rs7068256; rs4750770; rs10764890; rs11597422; rs4751104; rs11016887; rs7901881; rs10764889; rs3793910; rs11016908; rs7069143; rs7071424; rs491929; rs11596935; rs964369; rs487120; rs877185; rs3793903; rs12414229; rs7089735; rs1008982; rs11016899; rs557311; rs10829613; rs10829624; rs579325; rs10734088; rs557158; rs12415589; rs11817612; rs12573554; rs7924302; rs4751110; rs11016864; rs11016853; rs7098786; rs485579; rs3793914; rs7074106; rs4751117; rs1012827; rs10764904; rs11511217; rs693300; rs12764295; rs492811; rs11599610; rs11016903; rs7087624; rs12243174; rs12573565; rs10764895; rs12571103; rs10829617; rs7094634; rs3920717; rs12266078; rs12763287; rs471357; rs11816056; rs10764894; rs11016855; rs12257002; rs485576; rs12247354; rs516837; rs11016878; rs11594988; rs11016867; rs488116; rs4434913; rs3829196; rs11016836; rs12219606; rs1088116; rs7922814; rs10829625; rs11016902; rs7906680; rs4751105; rs12771521; rs4751103; rs11016861; rs4751119; rs11594188; rs12258311; rs11016873; rs12768004; rs11016869; rs12255679; rs12569708; rs11595020; rs11016905; rs7893831; rs10829612; rs10829609; rs12241533; rs10764902; rs7910554; rs12252708; rs12263730; rs12765218; rs7908104; rs12251756; rs7918174; rs1762461; rs2308326; rs11016891; rs7919354; rs7078233; rs7090061; rs7922452; rs3793904; rs12771882; rs12777397; rs7090323; rs2308323; rs12220782; rs1978757; rs7083430; rs12775171; rs11016884; rs12256016; rs7911018; rs496338; rs12251589; rs4456176; rs1929940; rs7909154; rs10764903; rs11016852; rs11815846; rs11598124; rs11597322; rs12221313; rs11016866; rs4750762; rs10829623; rs11016904; rs562240; rs1978756; rs7091444; rs7097519; rs12780525; rs7080171; rs12265939; rs11016895; rs1762462; rs2094292; rs7092208; rs7088864; rs11595486; rs4750769; rs11016894; rs7916591; rs11016879; rs11016889; rs7079165; rs563859; rs4986981; rs11016890; rs7098095; rs7084865; rs10764891; rs10466114; rs568166; rs496111; rs7899655; rs12780416; rs2308325; rs11016838; rs12569777; rs3793905; rs11592702; rs11016858; rs4986983; rs568918; rs7909964; rs12783998; rs12245575; rs580745; rs3793913; rs12251687; rs7918307; rs7896488; rs1625649; rs1711646; rs10764881; rs2308322; rs3750824; rs1042399; rs35645717; rs35229446; rs35761292; rs4751093; rs35068310; rs4751097; rs12254383; rs34558035; rs35511152; rs35769754; rs7092329; rs12244193; rs12253383; rs2676443; rs36052181; rs7070075; rs5788992; rs12263603; rs12766142; rs11277072; rs34152953; rs35650934; rs11016805; rs28540413; rs7083772; rs1711648; rs4253988; rs1537692; rs33985155; rs1970198; rs34686022; rs7086912; rs35085200; rs10741197; rs34189944; rs34380690; rs35208250; rs28436709; rs35389810; rs11016828; rs34274988; rs28652268; rs4751090; rs35429872; rs1537690; rs1771430; rs10642344; rs35934314; rs35468496; rs11279315; rs34279654; rs35004777; rs12269324; rs34697114; rs10687708; rs10642345; rs1762436; rs35370482; rs12241575; rs12249475; rs11016826; rs10697706; rs1711651; rs34202890; rs35005541; rs4421667; rs35626013; rs1537687; rs34996620; rs7477257; rs4498887; rs34705638; rs7083062; rs7907694; rs34349330; rs12776599; rs35695044; rs11016822; rs12262840; rs34723205; rs34327808; rs35786648; rs10741196; rs35612817; rs34492201; rs35318008; rs34049477; rs35492587; rs34956672; rs12263605; rs34152265; rs12253749; rs10640195; rs34676108; rs1711675; rs12268841; rs2027135; rs11016818; rs2676442; rs35675358; rs35902959; rs5788991; rs35203507; rs1711666; rs36079401; rs12776376; rs7080068; rs34874592; rs2388333; rs34960160; rs11016804; rs34005650; rs4322303; rs7900078; rs7083377; rs12258702; rs12358262; rs34542935; rs4751086; rs1711653; rs34064855; rs12240468; rs34220777; rs1413964; rs1932072; rs12259807; rs11597736; rs36167800; rs34762527; rs12249847; rs1771431; rs12257003; rs35305248; rs12268510; rs34777248; rs12265799; rs4423107; rs10466113; rs4750752; rs1762424; rs12776253; rs1762416; rs28455007; rs11331521; rs4751096; rs12240884; rs7907061; rs11016806; rs11016825; rs35617861; rs11311009; rs35900600; rs35778904; rs1711665; rs11016827; rs34860789; rs35476297; rs11016814; rs1762422; rs11016807; rs7906249; rs11591926; rs11817393; rs1711664; rs1771453; rs11315533; rs34874266; rs1762432; rs34754346; rs4751092; rs7907693; rs35066467; rs34749379; rs1762437; rs11599756; rs1556657; rs10552698; rs1623918; rs34760849; rs35720870; rs36096471; rs7095927; rs4603214; rs1335019; rs12268840; rs12241643; rs1807213; rs34830920; rs35410666; rs945223; rs10651712; rs1762434; rs35644088; rs1413963; rs34080232; rs1762435; rs4750753; rs34288617; rs11016819; rs11016832; rs34393666; rs7082744; rs16906255; rs7917287; rs12355286; rs36080560; rs34643875; rs36090834; rs34380518; rs510224; rs34173356; rs36188990; rs36088226; rs11591790; rs34143221; rs34218875; rs12570125; rs36018198; rs1627492; rs34970704; rs12248464; rs3852506; rs35146382; rs28832353; rs2892509; rs34066187; rs9418672; rs12766407; rs488269; rs579264; rs4751116; rs11016913; rs2484267; rs4317901; rs34000594; rs36030890; rs28832398; rs517162; rs35617444; rs12219799; rs35152308; rs35993895; rs36116890; rs34964184; rs28525982; rs36123668; rs35267106; rs569459; rs875431; rs10716014; rs34208708; rs11016892; rs7478479; rs34759985; rs11286370; rs35704654; rs28436018; rs11016845; rs11429171; rs34017989; rs12762024; rs12259671; rs34562106; rs12773817; rs12267600; rs28454573; rs516972; rs36027998; rs10543851; rs12781299; rs34095528; rs35291545; rs7475280; rs34055523; rs12776195; rs41282882; rs12246374; rs498964; rs34172947; rs12246315; rs35352179; rs34858211; rs11016835; rs34925197; rs11385209; rs34225481; rs11016839; rs7080347; rs1084700; rs34088913; rs4526694; rs7478209; rs2892510; rs11016912; rs34510643; rs35426916; rs34463549; rs35029056; rs34267586; rs11016851; rs41553133; rs10734087; rs35217106; rs7908602; rs12261395; rs1758215; rs4986980; rs474937; rs495614; rs11016907; rs34181065; rs35907506; rs11436102; rs7478480; rs4750767; rs3039559; rs34684008; rs35226365; rs12249441; rs11016846; rs35209504; rs570883; rs35527839; rs7905473; rs36057640; rs35356441; rs511110; rs34719498; rs35349159; rs1332119; rs35716383; rs12250921; rs7096024; rs693214; rs12250801; rs11016896; rs35238247; rs11016859; rs10606297; rs2183876; rs34779164; rs536674; rs12253346; rs1627494; rs34985996; rs12764855; rs34624890; rs34167318; rs538879; rs12573116; rs35230328; rs3838775; rs35805232; rs41544714; rs28787293; rs11016871; rs35965727; rs35032262; rs35568668; rs12256173; rs9733032; rs516862; rs35890176; rs36031342; rs11321613; rs4573609; rs10593211; rs491146; rs35919479; rs10634898; rs34048807; rs12413808; rs7067949; rs11016900; rs34597497; rs34747536; rs12572924; rs35221961; rs12773727; rs10644344; rs34697526; rs502785; rs12784696; rs36130761; rs34967203; rs34470448; rs11428844; rs34622080; rs35169649; rs12242318; rs3039560; rs34799657; rs35921862; rs7913686; rs35014555; rs34639589; rs34651219; rs11016834; rs34224695; rs7099912; rs9971094; rs12259573; rs12253019; rs34349080; rs35617552; rs2839913; rs11016916; rs34280997; rs12241553; rs10599584; rs11354974; rs34436645; rs11016865; rs10566762; rs7476339; rs11016893; rs7905466; rs11016882; rs41544612; rs34839546; rs12762313; rs12268330; rs12252663; rs12571925; rs13377140; rs35912317; rs4537676; rs9971105; rs34206757; rs35757488; rs35331028; rs12766553; rs11449467; rs7475511; rs4483506; rs34175678; rs12256179; rs480468; rs510702; rs35524475; rs12356518; rs34526678; rs35918350; rs35221395; rs11016886; rs35474332; rs34030217; rs35521368; rs9971096; rs34157356; rs478477; rs11016860; rs34636064; rs28854311; rs11272915; rs34839228; rs11016854; rs11442309; rs7906945; rs34567760; rs35219032; rs11016872; rs35926028; rs34241009; rs35345883; rs11016847; rs36167354; rs35980486; rs35395816; rs11016840; rs34584520; rs35787611; rs35499681; rs28863496; rs11016868; rs34990063; rs11595599; rs7350437; rs35840829; rs7476018; rs34190518; rs12767926; rs4500403; rs5788995; rs34630124; rs34834778; rs35138881; rs35335268; rs11593778; rs28427056; rs34314179; rs35636912; rs1758216; rs35206234; rs34246263; rs11016917; rs6144154; rs7077796; rs28879149; rs35576272; rs12572423; rs35917966; rs41548018; rs492549; rs12359181; rs1182997; rs12785020; rs34502595; rs34885153; rs12355382; rs12356000; rs11527783; rs34364194; rs34851567; rs34514206; rs34193113; rs34179062; rs7905465; rs35329048; rs12773674; rs35053194; rs2183877; rs35820218; rs11511209; rs7919195; rs11016906; rs35995462; rs35021858; rs34212589; rs7894532; rs488301; rs12260308; rs34621775; rs11016849; rs7083094; rs11016870; rs12265108; rs34538240; rs11016915; rs11527791; rs12413713; rs35346722; rs34180180; rs1623007; rs11597616; rs36003727; rs35322871; rs34138162; rs2782888; rs10764906; rs10764907; rs10764908; rs10829627; rs10829628; rs10829629; rs10829630; rs11016798; rs11016803; rs11016920; rs11016921; rs11599020; rs11812115; rs11814601; rs11818949; rs12265758; rs12569636; rs1335018; rs1537689; rs1547175; rs1547177; rs1547549; rs1711649; rs1762438; rs1762439; rs1762440; rs1762441; rs1771452; rs1981116; rs34396058; rs34983556; rs35280395; rs3750825; rs3750826; rs3802688; rs4750771; rs550389; rs6482738; rs7070624; rs7071804; rs7076226; rs7082228; rs7082662; rs7897057; rs7897706; rs7902728; rs7914037; rs7915289; rs913120; rs964368

# Macromolecular_Interacting_Partner_2_General_References:
2405387; 2188979; 2394694; 2359121; 1985934; 8202360

# Macromolecular_Interacting_Partner_2_References:
16392811; 16428468

# Macromolecular_Interacting_Partner_3_ID:
8758

# Macromolecular_Interacting_Partner_3_Name:
Equilibrative nucleoside transporter 2

# Macromolecular_Interacting_Partner_3_Synonyms:
Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter; Equilibrative NBMPR-insensitive nucleoside transporter; Nucleoside transporter, ei-type; Solute carrier family 29 member 2; 36 kDa nucleolar protein HNP36; Hydrophobic nucleolar protein, 36 kDa; Delayed-early response protein 12

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC29A2

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Equilibrative nucleoside transporter 2
MARGDAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGNSTARILSTNHTG
PEDAFNFNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGSLLAILLLFALTAALVKVD
MSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLL
SMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQELETKAE
LLQSDENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLV
FTVTLSVFPAITAMVTSSTSPGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRL
LPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPR
QVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
456

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
50114

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.02

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
 Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_3_Signals:
1-24

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
13-33
70-90
99-119
124-144
162-182
193-213
291-311
324-344
360-380
386-406
432-452

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
2811137

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
S29A2_HUMAN (Q14542)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC29A2

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC29A2

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:11004

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Isoform 1:Cell membrane; multi-pass membrane protein. Isoform 2:Nucleus; nuclear membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1371 bp
ATGGCGCGAGGAGACGCCCCGCGGGACAGCTACCACCTGGTCGGGATCAGCTTCTTCATC
CTGGGGCTGGGCACCCTCCTTCCCTGGAACTTCTTCATCACCGCCATCCCGTACTTCCAG
GCGCGACTGGCCGGGGCCGGCAACAGCACAGCCAGGATCCTGAGCACCAACCACACGGGT
CCCGAGGATGCCTTCAACTTCAACAATTGGGTGACGCTGCTGTCCCAGCTGCCCCTGCTG
CTCTTCACCCTCCTCAACTCCTTCCTGTACCAGTGCGTCCCGGAGACGGTGCGCATTCTG
GGCAGCCTGCTGGCCATACTGCTGCTCTTTGCCCTGACAGCAGCGCTGGTCAAGGTGGAC
ATGAGCCCCGGACCCTTCTTCTCCATCACCATGGCCTCCGTCTGCTTCATCAACTCCTTC
AGTGCAGTCCTACAGGGCAGCCTCTTCGGGCAGCTGGGCACCATGCCCTCCACCTACAGC
ACCCTCTTCCTCAGCGGCCAGGGCCTGGCTGGGATCTTTGCTGCCCTTGCCATGCTCCTG
TCCATGGCCAGTGGCGTGGACGCCGAGACCTCTGCCCTGGGGTACTTTATCACGCCCTGT
GTGGGCATCCTCATGTCCATCGTGTGTTACCTGAGCCTGCCTCACCTGAAGTTTGCCCGC
TACTACCTGGCCAATAAATCATCCCAGGCCCAAGCTCAGGAGCTGGAGACCAAAGCTGAG
CTCCTCCAGTCTGATGAGAACGGGATTCCCAGTAGTCCCCAGAAAGTAGCTCTGACCCTG
GATCTTGACCTGGAGAAGGAGCCGGAATCAGAGCCAGATGAGCCCCAGAAGCCAGGAAAA
CCTTCAGTCTTCACTGTCTTCCAGAAGATCTGGCTGACAGCGCTGTGCCTTGTGTTGGTC
TTCACAGTCACCCTGTCCGTCTTCCCCGCCATCACAGCCATGGTGACCAGCTCCACCAGT
CCTGGGAAGTGGAGTCAGTTCTTCAACCCCATCTGCTGCTTCCTCCTCTTCAACATCATG
GACTGGCTGGGACGGAGCCTGACCTCTTACTTCCTGTGGCCAGACGAGGACAGCCGGCTG
CTGCCCCTGCTGGTCTGCCTGCGGTTCCTGTTCGTGCCCCTCTTCATGCTGTGCCACGTG
CCCCAGAGGTCCCGGCTGCCCATCCTCTTCCCACAGGATGCCTACTTCATCACCTTCATG
CTGCTCTTTGCCGTTTCTAATGGCTACCTGGTGTCCCTCACCATGTGCCTGGCGCCCAGG
CAGGTGCTGCCACACGAGAGGGAGGTGGCCGGCGCCCTCATGACCTTCTTCCTGGCCCTG
GGACTTTCCTGTGGAGCCTCCCTCTCCTTCCTCTTCAAGGCGCTGCTCTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF034102

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11q13

# Macromolecular_Interacting_Partner_3_SNPs:
rs8187661; rs1039593; rs3177514; rs4930358; rs7126064; rs2292123; rs2279861; rs2279862; rs7125100; rs7126018; rs12416747; rs1039594; rs10791872; rs8187658; rs3867130; rs12576299; rs1344410; rs12576293; rs12577196; rs4930178; rs4930359; rs12281049; rs4244813; rs7107191; rs7104297; rs17850744; rs17855425; rs12801227; rs34186490; rs34124904; rs11227466; rs4554890; rs3741366; rs10605893; rs11403442; rs7111197; rs10632640; rs35639157; rs35962792; rs7946434; rs33943132; rs34029417; rs1815807; rs35659701; rs7103571; rs35791794; rs10648232; rs11423263; rs34482391; rs1566871; rs11298226; rs12800796; rs35509820; rs11461356; rs35457397; rs1201452; rs1210071; rs34585457; rs12360603; rs1047029; rs10791871; rs12794121; rs34272485; rs7130857; rs8187644; rs8187646; rs8187647; rs8187657; rs8187659; rs8187660

# Macromolecular_Interacting_Partner_3_General_References:
9478986; 9396714; 7639753

# Macromolecular_Interacting_Partner_3_References:
Not Available

End of HMDB00132

Beginning of HMDB00133
# Accession_No:
HMDB00133

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-23 10:01:09

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Guanosine

# Description:
Guanosine is a nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a beta-N9-glycosidic bond. Guanosine can be phosphorylated to become GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP (guanosine diphosphate) and GTP (guanosine triphosphate). (Wikipedia)
The nucleoside guanosine exert important neuroprotective and neuromodulator roles in the central nervous system, which may be related to inhibition of the glutamatergic neurotransmission activity. Guanosine is the specific extracellular guanine-based purines effector and indicate that its conversion occurs not only in the central nervous system but also peripherally. (PMID: 16325434)

# Synonyms:
2-Amino-1,9-dihydro-9-b-D-ribofuranosyl-6H-purin-6-one; 2-amino-Inosine; 9-b-D-ribofuranosyl-Guanine; ribonucleoside; Guanosine; Vernine; b-D-Ribofuranoside guanine-9; 2-Amino-1,9-dihydro-9-beta-delta-ribofuranosyl-6H-purin-6-one; 9-beta-delta-ribofuranosyl-Guanine; beta-delta-Ribofuranoside guanine-9

# Chemical_IUPAC_Name:
Guanosine

# Chemical_Formula:
C10H13N5O5

# Chemical_Structure:
tbl_chemical:::HMDB00133_ZOOM.png:::119283210028746585

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00133_THUMB.png:::119283209824053442

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; primary alcohol; secondary alcohol; 1,2-diol; primary amine; primary aromatic amine; oxo(het)arene; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
283.09167

# Molecular_Weight_Avg:
283.24072

# Smiles_String_isomeric:
NC1=NC2=C(N=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1

# Smiles_String_canonical:
NC1=NC2=C(N=CN2C3OC(CO)C(O)C3O)C(=O)N1

# KEGG_Compound_ID:
C00387

# BioCyc_ID:
GUANOSINE

# PubChem_CID:
6802

# PubChem_SID:
831750; 12075474; 8154424; 828520; 151492; 828060; 149798; 834086; 8026828; 3133368; 585265; 8144918; 822708; 3677; 10318628; 841595; 7887938; 650442; 838453; 823402

# OMIM_ID:
164050

# Metagene_ID:
SEGAWA SYNDROME: 391; PURINE NUCLEOSIDE PHOSPHORYLASE DIFICIENCY: 403; HYPERPHENYLALANIEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY: 355

# BiGG_ID:
51567

# Wikipedia_ID:
Guanosine

# METLIN_ID:
87

# Ref_ID:
15116424; 10102915; 546939; 7877593

# ChEBI_ID:
16750

# CAS_Registry_Number:
118-00-3

# InChI:
InChI=1/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1

# Synthesis_Reference:
Pharmaceuticals based on xylosides and lyxosides of purine and pyrimidine bases for virus inhibition.     Imbach, Jean Louis; Gosselin, Gilles; De Rudder, Jean.  (Synthelabo S. A., Fr.).    Fr. Demande  (1983),     13 pp.

# Melting_Point:
239 oC

# Melting_Point_predicted:
148.2 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.7 mg/mL at 18 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
15.3 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-1.90 [SANGSTER (1993)]

# LogP_predicted:
-2.06 [Predicted by ALOGPS]; -1.9 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Guanosine.pdf:::1132562204475595620

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Guanosine.mol:::1132723809015893533

# SDF_File_[Text]:
tbl_chemical:::HMDB00133.sdf:::119283209399720519

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00133.pdb:::119283209687211037

# PDB_ID:
1IH7

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041026_P00_05_HW_1DP_presat.png:::115254709456589074

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041026_P00_05_HW_1DP_PRESAT_1.zip:::114460785120082319

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041026_P00_05_HW_1DP_Assigned.png:::115679270589167113

# C_NMR_Spectra:
tbl_cnmr:::041026_P00_05_HW_1DC_82.jpg:::114168459691214402

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041026_P00_05_HW_1DC_82.zip:::114168459687364744

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041026_P00_05_HW_1DC_82_Assigned.jpg:::115930353214317791

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041026_P00_05_HW_2DHSQC_23.jpg:::114617527291055022

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041026_P00_05_HW_2DHSQC_23.zip:::114617527291974788

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041026_P00_05_HW_2DHSQC_23_Assigned.jpg:::115930356534745076

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Guanosine.gif:::1132732112531194503

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00133_peaks.txt:::1156309567887148012

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Guanosine_C.gif:::1132737695392393886

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00133_peaks.txt:::115631075785140421

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00133L.png:::117555262355196444; Medium Energy:tbl_ms:::HMDB00133M.png:::117555267729114738; High Energy:tbl_ms:::HMDB00133H.png:::117555271297814208

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000091.png:::116899931131276948

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000091.txt:::116899931131240358

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000091.png:::11689082646718204

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000091.txt:::116890826500065303

# Cellular_Location:
Cytoplasm (Predicted from LogP); Extracellular; lysosome; mitochondria

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Blood; Cellular Cytoplasm; Urine

# Concentration_[Normal]:
Urine	0.13 (0.022-0.23)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	15116424
Urine	490.0	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	10102915
Blood	0.258 +/- 0.174	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	0.8 +/- 0.5	uM	Adult:>18_yrs_old	Both	Normal	546939
Cellular_Cytoplasm	4.5 +/- 2.9	uM	Adult:>18_yrs_old	Both	Normal	7877593


# Concentration_[Abnormal]:
Urine	35.0 - 2588.0	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Purine-nucleoside phosphorylase (PNP; EC 2.4.2.1) deficiency.	10102915


# Associated_Disorders:
Dystonia; Hyperphenylalaniemia due to Guanosine Triphosphate Cyclohydrolase Deficiency; Purine Nucleoside Phosphorylase Deficiency; Purine-nucleoside phosphorylase (PNP; EC 2.4.2.1) deficiency.

# Pathway_Names:
Pyruvate metabolism;Glycolysis;Fatty acid metabolism;Bile acid biosynthesis;Glycerolipid metabolism;Galactose metabolism;Glycosphingolipid metabolism;Pentose and glucuronate interconversions;Fructose and mannose metabolism

# Pathway_Images:
;Glycolysis.jpg;;;;;;;fructose_metabolism.jpg

# KEGG_Images:
map00620;map00010;map00071;map00120;map00561;map00052;map00600;map00040;map00051

# Pathway_Graphs:
;Glycolysis_Graph.jpg;;;;;;;fructose_metabolism_Graph.jpg

# Pathway_SBMLs:
;Glycolysis.xml;;;;;;;fructose_metabolism.xml

# Metabolic_Enzyme_1_ID:
6060

# Metabolic_Enzyme_1_Name:
Alcohol dehydrogenase class 3

# Metabolic_Enzyme_1_Synonyms:
Alcohol dehydrogenase class III; Alcohol dehydrogenase class chi chain; S-; hydroxymethylglutathione dehydrogenase; Glutathione- dependent formaldehyde dehydrogenase; FDH

# Metabolic_Enzyme_1_Gene_Name:
ADH5

# Metabolic_Enzyme_1_Protein_Sequence:
>Alcohol dehydrogenase class 3
MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGC
FPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGK
GLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGY
GAAVNTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATEC
INPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEE
IATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFE
LMHSGKSIRTVVKI

# Metabolic_Enzyme_1_Number_of_Residues:
374

# Metabolic_Enzyme_1_Molecular_Weight:
39725

# Metabolic_Enzyme_1_Theoretical_pI:
7.54

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione

# Metabolic_Enzyme_1_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_1_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.1.1.1;EC 1.1.1.284

# Metabolic_Enzyme_1_GenBank_ID_Protein:
178134

# Metabolic_Enzyme_1_SwissProt_ID:
ADHX_HUMAN (P11766)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ADH5

# Metabolic_Enzyme_1_Geneatlas_id:
ADH5

# Metabolic_Enzyme_1_hgnc_id:
HGNC:253

# Metabolic_Enzyme_1_PDB_ID:
1MC5

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1125 bp
ATGGCGAACGAGGTTATCAAGTGCAAGGCTGCAGTTGCTTGGGAGGCTGGAAAGCCTCTC
TCCATAGAGGAGATAGAGGTGGCACCCCCAAAGGCTCATGAAGTTCGAATCAAGATCATT
GCCACTGCGGTTTGCCACACCGATGCCTATACCCTGAGTGGAGCTGATCCTGAGGGTTGT
TTTCCAGTGATCTTGGGACATGAAGGTGCTGGAATTGTGGAAAGTGTTGGTGAGGGAGTT
ACTAAGCTGAAGGCGGGTGACACTGTCATCCCACTTTACATCCCACAGTGTGGAGAATGC
AAATTTTGTCTAAATCCTAAAACTAACCTTTGCCAGAAGATAAGAGTCACTCAAGGGAAA
GGATTAATGCCAGATGGTACCAGCAGATTTACTTGCAAAGGAAAGACAATTTTGCATTAC
ATGGGAACCAGCACATTTTCTGAATACACAGTTGTGGCTGATATCTCTGTTGCTAAAATA
GATCCTTTAGCACCTTTGGATAAAGTCTGCCTTCTAGGTTGTGGCATTTCAACCGGTTAT
GGTGCTGCTGTGAACACTGCCAAGTTGGAGCCTGGCTCTGTTTGTGCCGTCTTTGGTCTG
GGAGGAGTCGGATTGGCAGTTATCATGGGCTGTAAAGTGGCTGGTGCTTCCCGGATCATT
GGTGTGGACATCAATAAAGATAAATTTGCAAGGGCCAAAGAGTTTGGAGCCACTGAATGT
ATTAACCCTCAGGATTTTAGTAAACCCATCCAGGAAGTGCTCATTGAGATGACCGATGGA
GGAGTGGACTATTCCTTTGAATGTATTGGTAATGTGAAGGTCATGAGAGCAGCACTTGAG
GCATGTCACAAGGGCTGGGGCGTCAGCGTCGTGGTTGGAGTAGCTGCTTCAGGTGAAGAA
ATTGCCACTCGTCCATTCCAGCTGGTAACAGGTCGCACATGGAAAGGCACTGCCTTTGGA
GGATGGAAGAGTGTAGAAAGTGTCCCAAAGTTGGTGTCTGAATATATGTCCAAAAAGATA
AAAGTTGATGAATTTGTGACTCACAATCTGTCTTTTGATGAAATCAACAAAGCCTTTGAA
CTGATGCATTCTGGAAAGAGCATTCGAACTGTTGTAAAGATTTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M30471

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_1_Locus:
4q21-q25

# Metabolic_Enzyme_1_SNPs:
rs16996593; rs28730623; rs28730643; rs7669660; rs1803037; rs13832; rs11568816; rs6827292; rs12106; rs11547772; rs28730650; rs1061187; rs28730645; rs28730646; rs17028487; rs12697; rs28730649; rs1154410; rs7683802; rs896992; rs1154411; rs1154405; rs6846829; rs7683704; rs1154401; rs1154414; rs17028505; rs17028500; rs7658279; rs4699701; rs4699700; rs7688859; rs6852848; rs7658127; rs7658118; rs7666867; rs3018048; rs7688835; rs7688531; rs13109048; rs7688686; rs4699699; rs1154412; rs17595424; rs28730592; rs28730605; rs28894371; rs1154415; rs28730639; rs13145727; rs28985868; rs28730576; rs28730607; rs28730581; rs28730569; rs28730624; rs1154404; rs28730641; rs28730597; rs28730601; rs28730578; rs28730590; rs28730575; rs1154409; rs1154402; rs13118409; rs28730612; rs29001350; rs28730632; rs28730571; rs29001346; rs28730603; rs28730594; rs29001583; rs28730596; rs29001348; rs28730582; rs28730620; rs28730619; rs28730637; rs13127586; rs28730608; rs28730568; rs28730640; rs28894370; rs28730600; rs28730630; rs13146416; rs28730644; rs28730625; rs28730617; rs1154416; rs29001345; rs28730610; rs28730584; rs28730602; rs9799556; rs13125919; rs28730636; rs28730587; rs28730621; rs29001347; rs28730573; rs28730611; rs28730593; rs28730595; rs28730627; rs29001351; rs35123946; rs2866033; rs28730613; rs28730629; rs1154403; rs13119035; rs28730589; rs11934304; rs29001349; rs28730631; rs28730591; rs29001631; rs28730604; rs28730570; rs7684735; rs7679102; rs1154400; rs7684986; rs17216887; rs7662987; rs7667261; rs2602899; rs29001338; rs29001341; rs28730655; rs29001336; rs1230158; rs13132688; rs29001339; rs17028482; rs2851301; rs28987121; rs29001340; rs1050636; rs1050637; rs28730628; rs28730652; rs28730653; rs28730648; rs29001343; rs1803038; rs28730647; rs28730651; rs28730583; rs28730599; rs33990814; rs34370152; rs1154406; rs34443372; rs28730606; rs28730616; rs28730586; rs34609488; rs34912906; rs11317364; rs28730585; rs35796474; rs28730618; rs28730634; rs28730626; rs28730572; rs28894372; rs1154413; rs5860558; rs34470866; rs28730622; rs28730635; rs29001344; rs28730598; rs35169500; rs28894368; rs6148593; rs34594585; rs29001542; rs28730588; rs28730609; rs28730577; rs28730633; rs28730615; rs28730580; rs29001570; rs3805321; rs33981706; rs1154407; rs1235433; rs28730574; rs34763643; rs36160699; rs34146172; rs3792680; rs10618658; rs28730638; rs35904284; rs13133011; rs34452464; rs1154408; rs33972516; rs28730656; rs1048578; rs29001342; rs10582873; rs3974877; rs28730657; rs36093781; rs1048577; rs5860559; rs10560641; rs11455235; rs10616090; rs35101663; rs35815329; rs11553737; rs29001335; rs28730658; rs11292055; rs34834932; rs2187482; rs10587720; rs34985976; rs1130076; rs34439422; rs28730654; rs29001337; rs10006953; rs1230154; rs1230155; rs1230157; rs1230164; rs1230165; rs1238741; rs1311615; rs1311616; rs1311617; rs1311621; rs13120000; rs1312200; rs1473371; rs15193; rs17028473; rs17595102; rs17595186; rs2602836; rs2851286; rs28730614; rs2924584; rs7664906; rs7667424; rs7681427; rs7687322

# Metabolic_Enzyme_1_General_References:
2818582; 2679557; 1446828; 3365377; 8494891; 8460164; 9018047

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6062

# Metabolic_Enzyme_2_Name:
Alcohol dehydrogenase 1B

# Metabolic_Enzyme_2_Synonyms:
Alcohol dehydrogenase beta subunit

# Metabolic_Enzyme_2_Gene_Name:
ADH1B

# Metabolic_Enzyme_2_Protein_Sequence:
>Alcohol dehydrogenase 1B
MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVT
PLPVILGHEA
AGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGN
PRGTLQDGTRRFTCRGKPIHH
FLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFS
TGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVM
GCKAAGAARIIAVDINKDKFAKAKELG
ATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASL
LCCHEACGTSVIVGVP
PASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHV
LPFEK
INEGFDLLHSGKSIRTVLTF

# Metabolic_Enzyme_2_Number_of_Residues:
375

# Metabolic_Enzyme_2_Molecular_Weight:
39855

# Metabolic_Enzyme_2_Theoretical_pI:
8.38

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
An alcohol + NAD(+) = an aldehyde or ketone + NADH

# Metabolic_Enzyme_2_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_2_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
178098

# Metabolic_Enzyme_2_SwissProt_ID:
ADH1B_HUMAN (P00325)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ADH1B

# Metabolic_Enzyme_2_Geneatlas_id:
ADH1B

# Metabolic_Enzyme_2_hgnc_id:
HGNC:250

# Metabolic_Enzyme_2_PDB_ID:
1HSZ

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1128 bp

ATGAGCACAGCAGGAAAAGTAATCAAATGCAAAGCAGCTGTGCTATGGGAGGTAAAGAA
ACCCTTTTCCA
TTGAGGATGTGGAGGTTGCACCTCCTAAGGCTTATGAAGTTCGCATTA
AGATGGTGGCTGTAGGAATCTG
TCGCACAGATGACCACGTGGTTAGTGGCAACCTGGTG
ACCCCCCTTCCTGTGATTTTAGGCCATGAGGCA
GCCGGCATCGTGGAGAGTGTTGGAGA
AGGGGTGACTACAGTCAAACCAGGTGATAAAGTCATCCCGCTCT
TTACTCCTCAGTGTG
GAAAATGCAGAGTTTGTAAAAACCCGGAGAGCAACTACTGCTTGAAAAATGATCT
AGGC
AATCCTCGGGGGACCCTGCAGGATGGCACCAGGAGGTTCACCTGCAGGGGGAAGCCCATT
CACCAC
TTCCTTGGCACCAGCACCTTCTCCCAGTACACGGTGGTGGATGAGAATGCAGT
GGCCAAAATTGATGCAG
CCTCGCCCCTGGAGAAAGTCTGCCTCATTGGCTGTGGATTCT
CGACTGGTTATGGGTCTGCAGTTAACGT
TGCCAAGGTCACCCCAGGCTCTACCTGTGCT
GTGTTTGGCCTGGGAGGGGTCGGCCTATCTGCTGTTATG
GGCTGTAAAGCAGCTGGAGC
AGCCAGAATCATTGCGGTGGACATCAACAAGGACAAAAAAGCAAAGGCCA
AAGAGTTGG
GTGCCACTGAATGCATCAACCCTCAAGACTACAAGAAACCCATCCAGGAAGTGCTAAAGG
A
AATGACTGATGGAGGTGTGGATTTTTCGTTTGAAGTCATCGGTCGGCTTGACACCATG
ATGGCTTCCCTG
TTATGTTGTCATGAGGCATGTGGCACAAGCGTCATCGTAGGGGTACC
TCCTGCTTCCCAGAACCTCTCAA
TAAACCCTATGCTGCTACTGACTGGACGCACCTGGA
AGGGGGCTGTTTATGGTGGCTTTAAGAGTAAAGA
AGGTATCCCAAAACTTGTGGCTGAT
TTTATGGCTAAGAAGTTTTCACTGGATGCGTTAATAACCCATGTT
TTACCTTTTGAAAA
AATAAATGAAGGATTTGACCTGCTTCACTCTGGGAAAAGTATCCGTACCGTCCTGA
CGT
TTTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M24317

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_2_Locus:
4q21-q23

# Metabolic_Enzyme_2_SNPs:
rs6413413; rs2066702; rs1229984; rs1041969; rs28626993; rs1789882; rs2018417; rs1229983; rs1042026; rs17033; rs28914789; rs3840296; rs28914788; rs1353621; rs12498658; rs1693457; rs17028834; rs6850217; rs10005290; rs2066701; rs9282578; rs11730075; rs2075633; rs9282577; rs4147536; rs28913906; rs28914783; rs1235416; rs28914772; rs13133908; rs28914770; rs28914773; rs1229985; rs28914769; rs28913922; rs1789880; rs1229986; rs28913915; rs1789883; rs28914768; rs28914775; rs4147539; rs28914785; rs7673353; rs28914784; rs28913924; rs28913907; rs2018613; rs28913921; rs1159918; rs12507573; rs3811801; rs3811802; rs1229982; rs1693458; rs1229981; rs2070898; rs28913902; rs2070897; rs28914792; rs28913901; rs28914793; rs1789878; rs3133155; rs28914794; rs28913903; rs1126441; rs41275699; rs1126440; rs41275697; rs28914790; rs35274586; rs3211503; rs34503441; rs35273731; rs28913919; rs28914777; rs28913926; rs28914782; rs34044126; rs28913909; rs17028839; rs7441278; rs28913916; rs34689791; rs28913918; rs28914786; rs35046750; rs28914781; rs35105761; rs28914776; rs28913911; rs10711677; rs4147538; rs28914780; rs7435646; rs34702119; rs28913923; rs28914779; rs4147535; rs28913913; rs28913920; rs28913908; rs28913914; rs28913910; rs28913917; rs28913925; rs35822752; rs28914778; rs28913912; rs28914787; rs10033960; rs34198524; rs28914774; rs3840297; rs28914791; rs13114844; rs5860575; rs1789877; rs34004679; rs36208360; rs34739423; rs6839995; rs36038206; rs28913904; rs28913905; rs34644331; rs1789879; rs35468479; rs1229863; rs1229864; rs13103321; rs13117371; rs13145277; rs1693439; rs1789888; rs1789890; rs1789891; rs2213041; rs2866152; rs6810842; rs9307239

# Metabolic_Enzyme_2_General_References:
3000832; 2935533; 2935875; 2679216; 2547609; 6391920; 3397059; 6374651; 3619918; 1896463; 8201622; 8663387; 11274460; 10733556

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5546

# Metabolic_Enzyme_3_Name:
Carnitine O-palmitoyltransferase 2, mitochondrial precursor

# Metabolic_Enzyme_3_Synonyms:
Carnitine palmitoyltransferase II; CPT II

# Metabolic_Enzyme_3_Gene_Name:
CPT2

# Metabolic_Enzyme_3_Protein_Sequence:
>Carnitine Opalmitoyltransferase 2, mitochondrial precursor
MVPRLLLRAWPRGPAVGPGAPSRPLSAGSGPGQYLQRSIVPTMHYQDSLPRLPIPKLEDT
IRRYLSAQKPLLNDGQFRKTEQFCKSFENGIGKELHEQLVALDKQNKHTSYISGPWFDMY
LSARDSVVLNFNPFMAFNPDPKSEYNDQLTRATNMTVSAIRFLKTLRAGLLEPEVFHLNP
AKSDTITFKRLIRFVPSSLSWYGAYLVNAYPLDMSQYFRLFNSTRLPKPSRDELFTDDKA
RHLLVLRKGNFYIFDVLDQDGNIVSPSEIQAHLKYILSDSSPAPEFPLAYLTSENRDIWA
ELRQKLMSSGNEESLRKVDSAVFCLCLDDFPIKDLVHLSHNMLHGDGTNRWFDKSFNLII
AKDGSTAVHFEHSWGDGVAVLRFFNEVFKDSTQTPAVTPQSQPATTDSTVTVQKLNFELT
DALKTGITAAKEKFDATMKTLTIDCVQFQRGGKEFLKKQKLSPDAVAQLAFQMAFLRQYG
QTVATYESCSTAAFKHGRTETIRPASVYTKRCSEAFVREPSRHSAGELQQMMVECSKYHG
QLTKEAAMGQGFDRHLFALRHLAAAKGIILPELYLDPAYGQINHNVLSTSTLSSPAVNLG
GFAPVVSDGFGVGYAVHDNWIGCNVSSYPGRNAREFLQCVEKALEDMFDALEGKSIKS

# Metabolic_Enzyme_3_Number_of_Residues:
658

# Metabolic_Enzyme_3_Molecular_Weight:
73778

# Metabolic_Enzyme_3_Theoretical_pI:
8.30

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Palmitoyl-CoA + L-carnitine = CoA + L- palmitoylcarnitine

# Metabolic_Enzyme_3_Pathway:
map00071  Fatty acid metabolism

# Metabolic_Enzyme_3_Reaction:
palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00755:Carn_acyltransf

# Metabolic_Enzyme_3_Signals:
1-15

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.3.1.21

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1041195

# Metabolic_Enzyme_3_SwissProt_ID:
CPT2_HUMAN (P23786)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
CPT2

# Metabolic_Enzyme_3_Geneatlas_id:
CPT2

# Metabolic_Enzyme_3_hgnc_id:
HGNC:2330

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane

# Metabolic_Enzyme_3_Gene_Sequence:
>1977 bp
ATGGTGCCCCGCCTGCTGCTGCGCGCCTGGCCCCGGGGCCCCGCGGTTGGTCCGGGAGCC
CCCAGTCGGCCCCTCAGCGCCGGCTCCGGGCCCGGCCAGTACCTGCAGCGCAGCATCGTG
CCCACCATGCACTACCAGGACAGCCTGCCCAGGCTGCCTATTCCCAAACTTGAAGACACC
ATTAGGAGATACCTCAGTGCACAGAAGCCTCTCTTGAATGATGGCCAGTTCAGGAAAACA
GAACAATTTTGCAAGAGTTTTGAAAATGGGATTGGAAAAGAACTGCATGAGCAGCTGGTT
GCTCTGGACAAACAGAATAAACATACAAGCTACATTTCGGGACCCTGGTTTGATATGTAC
CTATCTGCTCGAGACTCCGTTGTTCTGAACTTTAATCCATTTATGGCTTTCAATCCTGAC
CCAAAATCTGAGTATAATGACCAGCTCACCCGGGCAACCAACATGACTGTTTCTGCCATC
CGGTTTCTGAAGACACTCCGGGCTGGCCTTCTGGAGCCAGAAGTGTTCCACTTGAACCCT
GCAAAAAGTGACACTATCACCTTCAAGAGACTCATACGCTTTGTGCCTTCCTCTCTGTCC
TGGTATGGGGCCTACCTGGTCAATGCGTATCCCCTGGATATGTCCCAGTATTTTCGGCTT
TTCAACTCAACTCGTTTACCCAAACCCAGTCGGGATGAACTCTTCACTGATGACAAGGCC
AGACACCTCCTGGTCCTAAGGAAAGGAAATTTTTATATCTTTGATGTCCTGGATCAAGAT
GGGAACATTGTGAGCCCCTCGGAAATCCAGGCACATCTGAAGTACATTCTCTCAGACAGC
AGCCCCGCCCCCGAGTTTCCCCTGGCATACCTGACCAGTGAGAACCGAGACATCTGGGCA
GAGCTCAGGCAGAAGCTGATGAGTAGTGGCAATGAGGAGAGCCTGAGGAAAGTGGACTCG
GCAGTGTTCTGTCTCTGCCTAGATGACTTCCCCATTAAGGACCTTGTCCACTTGTCCCAC
AATATGCTGCATGGGGATGGCACAAACCGCTGGTTTGATAAATCCTTTAACCTCATTATC
GCCAAGGATGGCTCTACTGCCGTCCACTTTGAGCACTCTTGGGGTGATGGTGTGGCAGTG
CTCAGATTTTTTAATGAAGTATTTAAAGACAGCACTCAGACCCCTGCCGTCACTCCACAG
AGCCAGCCAGCTACCACTGACTCTACTGTCACGGTGCAGAAACTCAACTTCGAGCTGACT
GATGCCTTAAAGACTGGCATCACAGCTGCTAAGGAAAAGTTTGATGCCACCATGAAAACC
CTCACTATTGACTGCGTCCAGTTTCAGAGAGGAGGCAAAGAATTCCTGAAGAAGCAAAAG
CTGAGCCCTGACGCAGTTGCCCAGCTGGCATTCCAGATGGCCTTCCTGCGGCAGTACGGG
CAGACAGTGGCCACCTACGAGTCCTGTAGCACTGCCGCATTCAAGCACGGCCGCACTGAG
ACCATCCGCCCGGCCTCCGTCTATACAAAGAGGTGCTCTGAGGCCTTTGTCAGGGAGCCC
TCCAGGCACAGTGCTGGTGAGCTTCAGCAGATGATGGTTGAGTGCTCCAAGTACCATGGC
CAGCTGACCAAAGAAGCAGCAATGGGCCAGGGCTTTGACCGACACTTGTTTGCTCTGCGG
CATCTGGCAGCAGCCAAAGGGATCATCTTGCCTGAGCTCTACCTGGACCCTGCATACGGG
CAGATAAACCACAATGTCCTGTCCACGAGCACACTGAGCAGCCCAGCAGTGAACCTTGGG
GGCTTTGCCCCTGTGGTCTCTGATGGCTTTGGTGTTGGGTATGCTGTTCATGACAACTGG
ATAGGCTGCAATGTCTCTTCCTACCCAGGCCGCAATGCCCGGGAGTTTCTCCAATGTGTG
GAGAAGGCCTTAGAAGACATGTTTGATGCCTTAGAAGGCAAATCCATCAAAAGTTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U09648

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_3_Locus:
1p32

# Metabolic_Enzyme_3_SNPs:
rs1799821; rs2229291; rs1799822; rs2046138; rs737464; rs3766759; rs12754957; rs11578832; rs6692897; rs3766757; rs11581518; rs12058755; rs3766760; rs370493; rs12737375; rs729227; rs2062015; rs7539949; rs11206125; rs12403153; rs7554022; rs11206124; rs10888776; rs28936673; rs1871748; rs28936674; rs17848485; rs2229292; rs2929073; rs7545725; rs17848481; rs2127879; rs35539736; rs3766761; rs6669426; rs34032280; rs10651054; rs35615594; rs11441059; rs34546584; rs41294754; rs17856060; rs28749333; rs1072706; rs10700582; rs35567339; rs12117467; rs34661224; rs12072546; rs35891200; rs35237240; rs1056396; rs1056397; rs1056425; rs1134688; rs12140585; rs12567834; rs1679913; rs17108139; rs17108140; rs17369394; rs2275088; rs2297664; rs2929074; rs3014991; rs35027235; rs35316080; rs3736118; rs436887; rs6663121; rs6676576; rs6696436; rs7549319

# Metabolic_Enzyme_3_General_References:
1988962; 1961767; 7711730; 2174799; 1528846; 8358442; 8651281; 9600456; 10090476

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5545

# Metabolic_Enzyme_4_Name:
Lipoprotein lipase precursor

# Metabolic_Enzyme_4_Synonyms:
LPL

# Metabolic_Enzyme_4_Gene_Name:
LPL

# Metabolic_Enzyme_4_Protein_Sequence:
>Lipoprotein lipase precursor
MESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGV
AESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEH
YPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRIT
GLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQ
PGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKG
LCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQ
AFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDW
WSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLNKKSG

# Metabolic_Enzyme_4_Number_of_Residues:
475

# Metabolic_Enzyme_4_Molecular_Weight:
53163

# Metabolic_Enzyme_4_Theoretical_pI:
8.26

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  lipase activity
Function:  lipoprotein lipase activity
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). The enzyme functions in the presence of apolipoprotein C-2 on the luminal surface of vascular endothelium

# Metabolic_Enzyme_4_Pathway:
map00561  Glycerolipid metabolism

# Metabolic_Enzyme_4_Reaction:
triacylglycerol + H2O = diacylglycerol + a carboxylate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00151:Lipase;
PF01477:PLAT

# Metabolic_Enzyme_4_Signals:
1-27

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.1.1.34

# Metabolic_Enzyme_4_GenBank_ID_Protein:
307138

# Metabolic_Enzyme_4_SwissProt_ID:
LIPL_HUMAN (P06858)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
LPL

# Metabolic_Enzyme_4_Geneatlas_id:
LPL

# Metabolic_Enzyme_4_hgnc_id:
HGNC:6677

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Metabolic_Enzyme_4_Gene_Sequence:
>1428 bp
ATGGAGAGCAAAGCCCTGCTCGTGCTGACTCTGGCCGTGTGGCTCCAGAGTCTGACCGCC
TCCCGCGGAGGGGTGGCCGCCGCCGACCAAAGAAGAGATTTTATCGACATCGAAAGTAAA
TTTGCCCTAAGGACCCCTGAAGACACAGCTGAGGACACTTGCCACCTCATTCCCGGAGTA
GCAGAGTCCGTGGCTACCTGTCATTTCAATCACAGCAGCAAAACCTTCATGGTGATCCAT
GGCTGGACGGTAACAGGAATGTATGAGAGTTGGGTGCCAAAACTTGTGGCCGCCCTGTAC
AAGAGAGAACCAGACTCCAATGTCATTGTGGTGGACTGGCTGTCACGGGCTCAGGAGCAT
TACCCAGTGTCCGCGGGCTACACCAAACTGGTGGGACAGGATGTGGCCCGGTTTATCAAC
TGGATGGAGGAGGAGTTTAACTACCCTCTGGACAATGTCCATCTCTTGGGATACAGCCTT
GGAGCCCATGCTGCTGGCATTGCAGGAAGTCTGACCAATAAGAAAGTCAACAGAATTACT
GGCCTCGATCCAGCTGGACCTAACTTTGAGTATGCAGAAGCCCCGAGTCGTCTTTCTCCT
GATGATGCAGATTTTGTAGACGTCTTACACACATTCACCAGAGGGTCCCCTGGTCGAAGC
ATTGGAATCCAGAAACCAGTTGGGCATGTTGACATTTACCCGAATGGAGGTACTTTTCAG
CCAGGATGTAACATTGGAGAAGCTATCCGCGTGATTGCAGAGAGAGGACTTGGAGATGTG
GACCAGCTAGTGAAGTGCTCCCACGAGCGCTCCATTCATCTCTTCATCGACTCTCTGTTG
AATGAAGAAAATCCAAGTAAGGCCTACAGGTGCAGTTCCAAGGAAGCCTTTGAGAAAGGG
CTCTGCTTGAGTTGTAGAAAGAACCGCTGCAACAATCTGGGCTATGAGATCAATAAAGTC
AGAGCCAAAAGAAGCAGCAAAATGTACCTGAAGACTCGTTCTCAGATGCCCTACAAAGTC
TTCCATTACCAAGTAAAGATTCATTTTTCTGGGACTGAGAGTGAAACCCATACCAATCAG
GCCTTTGAGATTTCTCTGTATGGCACCGTGGCCGAGAGTGAGAACATCCCATTCACTCTG
CCTGAAGTTTCCACAAATAAGACCTACTCCTTCCTAATTTACACAGAGGTAGATATTGGA
GAACTACTCATGTTGAAGCTCAAATGGAAGAGTGATTCATACTTTAGCTGGTCAGACTGG
TGGAGCAGTCCCGGCTTCGCCATTCAGAAGATCAGAGTAAAAGCAGGAGAGACTCAGAAA
AAGGTGATCTTCTGTTCTAGGGAGAAAGTGTCTCATTTGCAGAAAGGAAAGGCACCTGCG
GTATTTGTGAAATGCCATGACAAGTCTCTGAATAAGAAGTCAGGCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M15856

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_4_Locus:
8p22

# Metabolic_Enzyme_4_SNPs:
rs328; rs5934; rs300; rs298; rs268; rs316; rs1121923; rs248; rs299; rs1059611; rs3866471; rs3208305; rs4922115; rs3735964; rs3289; rs13702; rs11570892; rs3200218; rs15285; rs1059507; rs11570893; rs17091815; rs7818177; rs255; rs1534649; rs263; rs327; rs260; rs301; rs264; rs8176337; rs330; rs320; rs326; rs12679834; rs281; rs297; rs331; rs295; rs312; rs251; rs291; rs270; rs261; rs282; rs253; rs325; rs10099160; rs3735959; rs17410577; rs3779788; rs262; rs303; rs249; rs17116619; rs269; rs319; rs283; rs271; rs254; rs256; rs7005541; rs3779787; rs322; rs7000460; rs314; rs266; rs6997330; rs10503668; rs343; rs258; rs13266204; rs285; rs6999612; rs9282781; rs287; rs10104051; rs11570899; rs278; rs257; rs34500595; rs8176338; rs276; rs259; rs17091775; rs6991305; rs305; rs1031045; rs289; rs290; rs10283151; rs252; rs7016529; rs11570891; rs9282782; rs329; rs279; rs7002728; rs310; rs292; rs34309063; rs280; rs12544438; rs302; rs277; rs304; rs318; rs3916027; rs1470187; rs4921684; rs1800590; rs1470186; rs4921683; rs17091742; rs17091738; rs35620080; rs9644636; rs35414700; rs1801177; rs11542065; rs11570895; rs1800011; rs10645926; rs11542064; rs36100146; rs11570896; rs1803923; rs1059497; rs1803924; rs28582042; rs311; rs35790715; rs10558335; rs288; rs34613868; rs308; rs34216128; rs272; rs294; rs28689946; rs323; rs2898492; rs35778379; rs35739027; rs13252357; rs274; rs11570898; rs307; rs315; rs11441041; rs313; rs34951282; rs4416836; rs28439839; rs284; rs247; rs28599962; rs34123038; rs2583659; rs33942567; rs33969952; rs324; rs13261181; rs28615996; rs309; rs10095748; rs286; rs34153784; rs296; rs265; rs275; rs28445964; rs11570897; rs293; rs13257355; rs34627627; rs33936024; rs10634207; rs267; rs28575919; rs28681081; rs2075651; rs10578695; rs7839976; rs273; rs1799744; rs35459867; rs34031063; rs11320112; rs28645722; rs28716400; rs11570894; rs28424158; rs2698206; rs321; rs28578146; rs306; rs34513350; rs10091085; rs10092029; rs10095784; rs10096633; rs10097668; rs10100638; rs10100898; rs10100904; rs10101760; rs10105606; rs1011685; rs11995036; rs12680065; rs1372339; rs1441777; rs1561750; rs1569209; rs17091870; rs17091872; rs17091879; rs17482753; rs2083638; rs2119691; rs2197089; rs2410616; rs2410617; rs2898493; rs4922116; rs6651471; rs6651484; rs7009128; rs7014261; rs7816032; rs7825694; rs7833094; rs7834459; rs7837974; rs7845291; rs8180932

# Metabolic_Enzyme_4_General_References:
3823907; 2701938; 2243796; 1537564; 1406652; 2340307; 1371284; 8308035; 8325986; 1598907; 1479292; 2010533; 8301230; 1730727; 1907278; 1521525; 8486765; 2110364; 8288243; 1969408; 1975597; 1619366; 1674945; 1702428; 1400331; 1752947; 2038366; 2121025; 1639392; 7647785; 8096693; 8135797; 7806969; 8956048; 9298816; 9401010; 9719626; 9662394; 10391209; 12966036

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
6063

# Metabolic_Enzyme_5_Name:
Alcohol dehydrogenase class 4 mu/sigma chain

# Metabolic_Enzyme_5_Synonyms:
Alcohol dehydrogenase class IV mu/sigma chain; Retinol dehydrogenase; Gastric alcohol dehydrogenase

# Metabolic_Enzyme_5_Gene_Name:
ADH7

# Metabolic_Enzyme_5_Protein_Sequence:
>Alcohol dehydrogenase class 4 mu/sigma chain
MGTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVS
KFPVIVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGR
GVLADGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGY
GAAVKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATEC
ISPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSAKM
LTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITHVLPFKKISEGFE
LLNSGQSIRTVLTF

# Metabolic_Enzyme_5_Number_of_Residues:
374

# Metabolic_Enzyme_5_Molecular_Weight:
40006

# Metabolic_Enzyme_5_Theoretical_pI:
8.08

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_5_Specific_Function:
Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism

# Metabolic_Enzyme_5_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_5_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_5_GenBank_ID_Protein:
516618

# Metabolic_Enzyme_5_SwissProt_ID:
ADH7_HUMAN (P40394)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ADH7

# Metabolic_Enzyme_5_Geneatlas_id:
ADH7

# Metabolic_Enzyme_5_hgnc_id:
HGNC:256

# Metabolic_Enzyme_5_PDB_ID:
1D1S

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1125 bp
ATGGGCACTGCTGGAAAAGTTATTAAGTGCAAAGCAGCTGTGCTTTGGGAGCAGAAGCAA
CCCTTCTCCATTGAGGAAATAGAAGTTGCCCCACCAAAGACTAAAGAAGTTCGCATTAAG
ATTTTGGCCACAGGAATCTGTCGCACAGATGACCATGTGATAAAAGGAACAATGGTGTCC
AAGTTTCCAGTGATTGTGGGACATGAGGCAACTGGGATTGTAGAGAGCATTGGAGAAGGA
GTGACTACAGTGAAACCAGGTGACAAAGTCATCCCTCTCTTTCTGCCACAATGTAGAGAA
TGCAATGCTTGTCGCAACCCAGATGGCAACCTTTGCATTAGGAGCGATATTACTGGTCGT
GGAGTACTGGCTGATGGCACCACCAGATTTACATGCAAGGGCAAACCAGTCCACCACTTC
ATGAACACCAGTACATTTACCGAGTACACAGTGGTGGATGAATCTTCTGTTGCTAAGATT
GATGATGCAGCTCCTCCTGAGAAAGTCTGTTTAATTGGCTGTGGGTTTTCCACTGGATAT
GGCGCTGCTGTTAAAACTGGCAAGGTCAAACCTGGTTCCACTTGCGTCGTCTTTGGCCTG
GGAGGAGTTGGCCTGTCAGTCATCATGGGCTGTAAGTCAGCTGGTGCATCTAGGATCATT
GGGATTGACCTCAACAAAGACAAATTTGAGAAGGCCATGGCTGTAGGTGCCACTGAGTGT
ATCAGTCCCAAGGACTCTACCAAACCCATCAGTGAGGTGCTGTCAGAAATGACAGGCAAC
AACGTGGGATACACCTTTGAAGTTATTGGGCATCTTGAAACCATGATTGATGCCCTGGCA
TCCTGCCACATGAACTATGGGACCAGCGTGGTTGTAGGAGTTCCTCCATCAGCCAAGATG
CTCACCTATGACCCGATGTTGCTCTTCACTGGACGCACATGGAAGGGATGTGTCTTTGGA
GGTTTGAAAAGCAGAGATGATGTCCCAAAACTAGTGACTGAGTTCCTGGCAAAGAAATTT
GACCTGGACCAGTTGATAACTCATGTTTTACCATTTAAAAAAATCAGTGAAGGATTTGAG
CTGCTCAATTCAGGACAAAGCATTCGAACGGTCCTGACGTTTTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
L33179

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_5_Locus:
4q23-q24

# Metabolic_Enzyme_5_SNPs:
rs1573496; rs971074; rs894369; rs284787; rs3805331; rs3805329; rs284786; rs4147554; rs17029033; rs17537595; rs1154456; rs284784; rs1154460; rs284785; rs2584464; rs1154467; rs1154459; rs4147549; rs1154458; rs2851011; rs1827567; rs1154457; rs12504511; rs284779; rs930478; rs1154461; rs1154455; rs1154454; rs1229797; rs1154464; rs4147553; rs1154469; rs2851297; rs17529377; rs7693230; rs284798; rs17588403; rs17588761; rs17029037; rs1154468; rs3737482; rs17529509; rs12499297; rs2584465; rs4147552; rs17029035; rs12502365; rs12510051; rs17529530; rs1154470; rs729147; rs284789; rs1154453; rs284790; rs2851012; rs4147555; rs2654847; rs1154471; rs284797; rs1042111; rs34907712; rs1154462; rs34061749; rs35268476; rs28418615; rs2866159; rs34652525; rs35672109; rs36008509; rs2866158; rs28712290; rs34555199; rs1154466; rs11480228; rs4147551; rs11359125; rs35475511; rs4147550; rs35065328; rs35006747; rs1154465; rs36166167; rs34553961; rs2860159; rs4318659; rs7690256; rs13137887; rs34682744; rs2851031; rs2866160; rs12502381; rs13146108; rs35816713; rs1154463; rs6831961; rs36084955; rs2851030; rs34925826; rs422143; rs33995120; rs2851028; rs34216119; rs3076141; rs2851296; rs2584463; rs34090033; rs377582; rs1154452; rs284788; rs34457649; rs34867051; rs437106; rs10020840; rs1154472; rs1154473; rs1154474; rs1154475; rs1154476; rs1154477; rs1154480; rs1154481; rs1154483; rs13104075; rs1348276; rs1442477; rs1442488; rs1442489; rs1442490; rs1553434; rs17028991; rs17587689; rs2083687; rs2083688; rs2099855; rs2202291; rs2584462; rs2654848; rs284791; rs284792; rs284793; rs2851295; rs400144; rs4699382; rs7435475; rs7663410; rs7668420; rs7696921; rs969804; rs994771; rs994772

# Metabolic_Enzyme_5_General_References:
8195208; 7876191; 7925371; 8082805; 7876099; 7771649; 1592118; 9228021

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5754

# Metabolic_Enzyme_6_Name:
Alcohol dehydrogenase [NADP+]

# Metabolic_Enzyme_6_Synonyms:
Aldehyde reductase; Aldo- keto reductase family 1 member A1

# Metabolic_Enzyme_6_Gene_Name:
AKR1A1

# Metabolic_Enzyme_6_Protein_Sequence:
>Alcohol dehydrogenase NADP+
MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL
KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER
GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP
AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK
YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV
PMLTVDGKRVPRDAGHPLYPFNDPY

# Metabolic_Enzyme_6_Number_of_Residues:
325

# Metabolic_Enzyme_6_Molecular_Weight:
36573

# Metabolic_Enzyme_6_Theoretical_pI:
6.79

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Catalyzes the NADPH-dependent reduction of a variety of aldehydes to their corresponding alcohols

# Metabolic_Enzyme_6_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00561  Glycerolipid metabolism;
 map00930  Caprolactam degradation

# Metabolic_Enzyme_6_Reaction:
an alcohol + NADP+ = an aldehyde + NADPH + H+

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.1.1.2

# Metabolic_Enzyme_6_GenBank_ID_Protein:
178481

# Metabolic_Enzyme_6_SwissProt_ID:
AK1A1_HUMAN (P14550)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
AKR1A1

# Metabolic_Enzyme_6_Geneatlas_id:
AKR1A1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:380

# Metabolic_Enzyme_6_PDB_ID:
2ALR

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>978 bp
ATGGCGGCTTCCTGTGTTCTACTGCACACTGGGCAGAAGATGCCTCTGATTGGTCTGGGT
ACCTGGAAGAGTGAGCCTGGTCAGGTAAAAGCAGCTGTTAAGTATGCCCTTAGCGTAGGC
TACCGCCACATTGATTGTGCTGCTATCTACGGCAATGAGCCTGAGATTGGGGAGGCCCTG
AAGGAGGACGTGGGACCAGGCAAGGCGGTGCCTCGGGAGGAGCTGTTTGTGACATCCAAG
CTGTGGAACACCAAGCACCACCCCGAGGATGTGGAGCCTGCCCTCCGGAAGACTCTGGCT
GACCTCCAGCTGGAGTATCTGGACCTGTACCTGATGCACTGGCCTTATGCCTTTGAGCGG
GGAGACAACCCCTTCCCCAAGAATGCTGATGGGACTATATGCTACGACTCCACCCACTAC
AAGGAGACTTGGAAGGCTCTGGAGGCACTGGTGGCTAAGGGGCTGGTGCAGGCGCTGGGC
CTGTCCAACTTCAACAGTCGGCAGATTGATGACATACTCAGTGTGGCCTCCGTGCGTCCA
GCTGTCTTGCAGGTGGAATGCCACCCATACTTGGCTCAAAATGAGCTAATTGCCCACTGC
CAAGCACGTGGCTTGGAGGTAACTGCTTATAGCCCTTTGGGCTCCTCTGATCGTGCATGG
CGTGATCCTGATGAGCCTGTCCTGCTGGAGGAACCAGTAGTCCTGGCATTGGCTGAAAAG
TATGGCCGATCTCCAGCTCAGATCTTGCTCAGGTGGCAGGTCCAGCGGAAAGTGATCTGC
ATCCCCAAAAGTATCACTCCTTCTCGAATCCTTCAGAACATCAAGGTGTTTGACTTCACC
TTTAGCCCAGAAGAGATGAAGCAGCTAAATGCCCTGAACAAAAATTGGAGATATATTGTG
CCTATGCTTACGGTGGATGGGAAGAGAGTCCCAAGGGATGCAGGGCATCCTCTGTACCCC
TTTAATGACCCGTACTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
J04794

# Metabolic_Enzyme_6_Chromosome_Location:
Not Available

# Metabolic_Enzyme_6_Locus:
Not Available

# Metabolic_Enzyme_6_SNPs:
Not Available

# Metabolic_Enzyme_6_General_References:
2498333; 10486210; 3615425; 7669785

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5758

# Metabolic_Enzyme_7_Name:
Alcohol dehydrogenase 4

# Metabolic_Enzyme_7_Synonyms:
Alcohol dehydrogenase class II pi chain

# Metabolic_Enzyme_7_Gene_Name:
ADH4

# Metabolic_Enzyme_7_Protein_Sequence:
>Alcohol dehydrogenase 4
MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEG
LAFPVIVGHE
AAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNL
KSPASDQQLMEDKTSRFTCKG
KPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLL
GCGFSTGYGAAINNAKVTPGSTCAVFGLGGVG
LSAVMGCKAAGASRIIGIDINSEKFVK
AKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSET
MKAALDCTTAGWGSCT
FIGVAAGSKGLTVFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDA
LVTHT
LPFDKISEAFDLMNQGKSIRTILIF

# Metabolic_Enzyme_7_Number_of_Residues:
380

# Metabolic_Enzyme_7_Molecular_Weight:
40222

# Metabolic_Enzyme_7_Theoretical_pI:
8.01

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_7_Specific_Function:
An alcohol + NAD(+) = an aldehyde or ketone + NADH

# Metabolic_Enzyme_7_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_7_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_7_GenBank_ID_Protein:
178121

# Metabolic_Enzyme_7_SwissProt_ID:
ADH4_HUMAN (P08319)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
ADH4

# Metabolic_Enzyme_7_Geneatlas_id:
ADH4

# Metabolic_Enzyme_7_hgnc_id:
HGNC:252

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_7_Gene_Sequence:
>1179 bp

ATGGGCACCAAGGGCAAAGTTATTAAATGCAAAGCAGCCATCGCCTGGGAAGCAGGCAA
GCCCCTTTGCA
TTGAAGAGGTTGAAGTAGCTCCCCCCAAGGCTCATGAAGTTCGCATTC
AGATCATTGCTACCTCCCTGTG
CCATACTGATGCCAGTGTTATCGATTCTAAATTTGAG
GGCCTAGCTTTCCCAGTGATCGTTGGCCATGAG
GCTGCAGGTATTGTGGAAAGTATTGG
GCCAGGAGTGACCAACGTCAAACCAGGTGACAAAGTAATTCCAC
TTTATGCACCTCTAT
GTAGAAAATGCAAGTTTTGTCTGAGTCCACTCACAAATTTGTGTGGGAAAATCAG
TAAT
CTCAAAAGTCCTGCTAGTGATCAACAACTAATGGAAGACAAAACCAGCAGGTTTACCTGC
AAAGGA
AAACCAGTTTACCATTTCTTTGGAACCAGTACATTCTCTCAGTACACTGTGGT
GTCAGATATCAATCTTG
CCAAAATAGATGATGATGCAAATTTAGAGAGAGTTTGTCTGC
TTGGATGTGGGTTTTCAACTGGCTATGG
GGCTGCAATCAACAATGCCAAGGTCACCCCT
GGTTCGACTTGTGCTGTCTTTGGCCTAGGAGGTGTGGGT
CTTTCTGCTGTAATGGGTTG
TAAAGCAGCAGGAGCTTCCAGAATCATAGGTATTGACATCAACAGTGAGA
AGTTTGTGA
AGGCTAAAGCCCTGGGAGCCACTGACTGCCTCAATCCTAGAGACTTACATAAACCGATCC
A
GGAAGTTATCATTGAATTGACCAAGGGAGGTGTGGATTTTGCCCTTGACTGTGCAGGT
GGATCTGAAACC
ATGAAAGCAGCCCTGGACTGTACAACCGCAGGCTGGGGATCATGTAC
TTTCATTGGAGTAGCTGCTGGTA
GCAAAGGATTGACTATTTTTCCAGAGGAGCTAATAA
TCGGCCGTACTATAAATGGAACATTCTTTGGTGG
TTGGAAAAGTGTAGATTCTATCCCA
AAGCTGGTCACTGACTATAAGAATAAGAAATTCAATCTGGATGCA
TTGGTGACCCATAC
CCTGCCTTTTGACAAAATCAGTGAGGCATTTGACCTAATGAACCAAGGAAAAAGCG
TCC
GAACAATCCTCATCTTTGGAAGATGCCAGGAGCAATTCAGAATACTATCTGATTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
M15943

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_7_Locus:
4q21-q24|4q22

# Metabolic_Enzyme_7_SNPs:
rs1126671; rs1126673; rs1126672; rs1126670; rs2032349; rs1042364; rs1042365; rs10097; rs1139490; rs4148886; rs7672728; rs7670060; rs6532798; rs2032348; rs6532799; rs2602895; rs7670241; rs7694646; rs13110764; rs2851247; rs7694844; rs4699714; rs17217949; rs6813415; rs10017466; rs13108999; rs7689753; rs6532797; rs6831352; rs2602894; rs28987095; rs17817868; rs17817359; rs3805322; rs7670638; rs9307234; rs7669636; rs7692974; rs17817958; rs6820625; rs13143133; rs2851248; rs10009145; rs17218162; rs13133647; rs17218239; rs17218602; rs1984360; rs6837685; rs17218003; rs13110176; rs2851246; rs17218141; rs6855482; rs29001203; rs4699713; rs17218560; rs13133633; rs17218108; rs6822348; rs17218073; rs4699712; rs10026860; rs6848050; rs17218288; rs13138294; rs6848576; rs4699710; rs6836440; rs13148577; rs4148890; rs28987097; rs29001202; rs29001236; rs29001218; rs29001221; rs13140423; rs28987090; rs28987088; rs13132999; rs34936974; rs4502688; rs29001175; rs1540054; rs29001209; rs29001192; rs29001223; rs29001216; rs7691700; rs29001214; rs5860563; rs29001194; rs29001222; rs29001188; rs29001208; rs28987100; rs6840413; rs29001234; rs29001229; rs5860565; rs28987102; rs13112924; rs29001227; rs2602897; rs3919370; rs4148887; rs13132776; rs29001232; rs29001190; rs28987092; rs29001211; rs6532800; rs29001237; rs13106879; rs28987089; rs13113166; rs13133214; rs29001224; rs28987098; rs4699715; rs13125262; rs13112733; rs29001235; rs6840888; rs29001199; rs13133140; rs29001183; rs29001177; rs29001217; rs29001170; rs6841113; rs29001215; rs28987101; rs1573495; rs29001195; rs13129488; rs29001212; rs13112176; rs29001207; rs29001196; rs1984361; rs13102874; rs29001231; rs1984365; rs2213035; rs29001210; rs13108745; rs4148888; rs10712996; rs2602896; rs13107558; rs29001201; rs2602891; rs4148884; rs2226896; rs3762894; rs4148883; rs1800761; rs2851253; rs4140388; rs4699716; rs6858148; rs2924583; rs1800760; rs2851249; rs1800759; rs2851251; rs2213034; rs29001169; rs2851252; rs2851254; rs2602893; rs2602890; rs4699717; rs35229514; rs29001219; rs1139492; rs35490064; rs1139491; rs1139489; rs29001238; rs35073321; rs35760460; rs29001182; rs35767213; rs33933720; rs29001205; rs34876213; rs35652689; rs34071486; rs35019093; rs13127582; rs29001198; rs4699711; rs29001181; rs29001176; rs29001171; rs33927405; rs35882815; rs28987094; rs29001213; rs29001186; rs29001230; rs29001197; rs29001178; rs35786878; rs36034266; rs28987099; rs29001200; rs34805407; rs28816225; rs34338603; rs29001225; rs34360292; rs29001172; rs11728281; rs34069499; rs11732799; rs35062722; rs35774359; rs34118841; rs29001220; rs29001204; rs29001174; rs29001233; rs41275695; rs3049429; rs29001180; rs35385089; rs10711227; rs4148891; rs33955894; rs28987096; rs29001189; rs29001193; rs35108469; rs13127153; rs35784540; rs29001228; rs28987093; rs10014222; rs5860564; rs29001226; rs29001179; rs35205530; rs34295744; rs35406734; rs33977891; rs11724440; rs28987091; rs2156732; rs33958017; rs29001173; rs35518660; rs35246304; rs29001184; rs29001191; rs35662508; rs5860566; rs11317458; rs35988291; rs29001650; rs28973169; rs35283873; rs28542574; rs3049432; rs34851571; rs10648918; rs28987087; rs2851250; rs34634551; rs3049427; rs33970666; rs10678943; rs35146617; rs10032099; rs12649136; rs17028615; rs1984362; rs1984364; rs2156731; rs2602865; rs2602866; rs2602874; rs2602875; rs2602876; rs2602877; rs2602878; rs2602883; rs2602884; rs2602885; rs2602886; rs2851255; rs2851256; rs2851257; rs3828541; rs4235435; rs4235436; rs4699718; rs4699720; rs6532795; rs6532796; rs7434491; rs7698301

# Metabolic_Enzyme_7_General_References:
3036213; 1889753

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5543

# Metabolic_Enzyme_8_Name:
Carnitine O-palmitoyltransferase I, muscle isoform

# Metabolic_Enzyme_8_Synonyms:
CPT I; CPTI-M; Carnitine palmitoyltransferase 1B; Carnitine palmitoyltransferase I-like protein

# Metabolic_Enzyme_8_Gene_Name:
CPT1B

# Metabolic_Enzyme_8_Protein_Sequence:
>Carnitine Opalmitoyltransferase I, muscle isoform
MAEAHQAVAFQFTVTPDGVDFRLSREALKHVYLSGINSWKKRLIRIKNGILRGVYPGSPT
SWLVVIMATVGSSFCNVDISLGLVSCIQRCLPQGCGPYQTPQTRALLSMAIFSTGVWVTG
IFFFRQTLKLLLCYHGWMFEMHGKTSNLTRIWAMCIRLLSSRHPMLYSFQTSLPKLPVPR
VSATIQRYLESVRPLLDDEEYYRMELLAKEFQDKTAPRLQKYLVLKSWWASNYVSDWWEE
YIYLRGRSPLMVNSNYYVMDLVLIKNTDVQAARLGNIIHAMIMYRRKLDREEIKPVMALG
IVPMCSYQMERMFNTTRIPGKDTDVLQHLSDSRHVAVYHKGRFFKLWLYEGARLLKPQDL
EMQFQRILDDPSPPQPGEEKLAALTAGGRVEWAQARQAFFSSGKNKAALEAIERAAFFVA
LDEESYSYDPEDEASLSLYGKALLHGNCYNRWFDKSFTLISFKNGQLGLNAEHAWADAPI
IGHLWEFVLGTDSFHLGYTETGHCLGKPNPALAPPTRLQWDIPKQCQAVIESSYQVAKAL
ADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDRGKFCLTYEASMTRMFREG
RTETVRSCTSESTAFVQAMMEGSHTKADLRDLFQKAAKKHQNMYRLAMTGAGIDRHLFCL
YLVSKYLGVSSPFLAEVLSEPWRLSTSQIPQSQIRMFDPEQHPNHLGAGGGFGPVADDGY
GVSYMIAGENTIFFHISSKFSSSETNAQRFGNHIRKALLDIADLFQVPKAYS

# Metabolic_Enzyme_8_Number_of_Residues:
772

# Metabolic_Enzyme_8_Molecular_Weight:
87802

# Metabolic_Enzyme_8_Theoretical_pI:
8.77

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
Palmitoyl-CoA + L-carnitine = CoA + L- palmitoylcarnitine

# Metabolic_Enzyme_8_Pathway:
map00071  Fatty acid metabolism

# Metabolic_Enzyme_8_Reaction:
palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00755:Carn_acyltransf

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
48-73
103-122

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.3.1.21

# Metabolic_Enzyme_8_GenBank_ID_Protein:
1621202

# Metabolic_Enzyme_8_SwissProt_ID:
CPT1B_HUMAN (Q92523)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
CPT1B

# Metabolic_Enzyme_8_Geneatlas_id:
CPT1B

# Metabolic_Enzyme_8_hgnc_id:
HGNC:2329

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; multi-pass membrane protein

# Metabolic_Enzyme_8_Gene_Sequence:
>2319 bp
ATGGCGGAAGCTCACCAGGCCGTGGCCTTCCAGTTCACGGTGACCCCAGACGGGGTCGAC
TTCCGGCTCAGTCGGGAGGCCCTGAAACACGTCTACCTGTCTGGGATCAACTCCTGGAAG
AAACGCCTGATCCGCATCAAGAATGGCATCCTCAGGGGCGTGTACCCTGGCAGCCCCACC
AGCTGGCTGGTCGTCATCATGGCAACAGTGGGTTCCTCCTTCTGCAACGTGGACATCTCC
TTGGGGCTGGTCAGTTGCATCCAGAGATGCCTCCCTCAGGGGTGTGGCCCCTACCAGACC
CCGCAGACCCGGGCACTTCTCAGCATGGCCATCTTCTCCACGGGCGTCTGGGTGACGGGC
ATCTTCTTCTTCCGCCAAACCCTGAAGCTGCTTCTCTGCTACCATGGGTGGATGTTTGAG
ATGCATGGCAAGACCAGCAACTTGACCAGGATCTGGGCTATGTGTATCCGCCTTCTATCC
AGCCGGCACCCTATGCTCTACAGCTTCCAGACATCTCTGCCCAAGCTTCCTGTGCCCAGG
GTGTCAGCCACAATTCAGCGGTACCTAGAGTCTGTGCGCCCCTTGTTGGATGATGAGGAA
TATTACCGCATGGAGTTGCTGGCCAAAGAATTCCAGGACAAGACTGCCCCCAGGCTGCAG
AAATACCTGGTGCTCAAGTCATGGTGGGCAAGTAACTATGTGAGTGACTGGTGGGAAGAG
TACATCTACCTTCGAGGCAGGAGCCCTCTCATGGTGAACAGCAACTATTATGTCATGGAC
CTTGTGCTCATCAAGAATACAGACGTGCAGGCAGCCCGCCTGGGAAACATCATCCACGCC
ATGATCATGTATCGCCGTAAACTGGACCGTGAAGAAATCAAGCCTGTGATGGCACTGGGC
ATAGTGCCTATGTGCTCCTACCAGATGGAGAGGATGTTCAACACCACTCGGATCCCGGGC
AAGGACACAGATGTGCTACAGCACCTCTCAGACAGCCGGCACGTGGCTGTCTACCACAAG
GGACGCTTCTTCAAGCTGTGGCTCTATGAGGGCGCCCGTCTGCTCAAGCCTCAGGATCTG
GAGATGCAGTTCCAGAGGATCCTGGACGACCCCTCCCCACCTCAGCCTGGGGAGGAGAAG
CTGGCAGCCCTCACTGCAGGAGGAAGGGTGGAGTGGGCGCAGGCACGCCAGGCCTTCTTT
AGCTCTGGAAAGAATAAGGCTGCCTTGGAGGCCATCGAGCGTGCCGCTTTCTTCGTGGCC
CTGGATGAGGAATCCTACTCCTATGACCCCGAAGATGAGGCCAGCCTCAGCCTCTATGGC
AAGGCCCTGCTACATGGCAACTGCTACAACAGGTGGTTTGACAAATCCTTCACTCTCATT
TCCTTCAAGAATGGCCAGTTGGGTCTCAATGCAGAGCATGCGTGGGCAGATGCTCCCATC
ATTGGGCACCTCTGGGAGTTTGTCCTGGGCACAGACAGCTTCCACCTGGGCTACACGGAG
ACCGGGCACTGCCTGGGCAAACCGAACCCTGCGCTCGCACCTCCTACACGGCTGCAGTGG
GACATTCCAAAACAGTGCCAGGCGGTCATCGAGAGTTCCTACCAGGTGGCCAAGGCGTTG
GCAGACGACGTGGAGTTGTACTGCTTCCAGTTCCTGCCCTTTGGCAAAGGCCTCATCAAG
AAGTGCCGGACCAGCCCTGATGCCTTTGTGCAGATCGCGCTGCAGCTGGCTCACTTCCGG
GACAGGGGTAAGTTCTGCCTGACCTATGAGGCCTCAATGACCAGAATGTTCCGGGAGGGA
CGGACTGAGACTGTGCGTTCCTGTACCAGCGAGTCCACAGCCTTTGTGCAGGCCATGATG
GAGGGGTCCCACACAAAAGCAGACCTGCGAGATCTCTTCCAGAAGGCTGCTAAGAAGCAC
CAGAATATGTACCGCCTGGCCATGACCGGGGCAGGGATCGACAGGCACCTCTTCTGCCTT
TACTTGGTCTCCAAGTACCTAGGAGTCAGCTCTCCTTTCCTTGCTGAGGTGCTCTCGGAA
CCCTGGCGTCTCTCCACCAGCCAGATCCCCCAATCCCAGATCCGCATGTTCGACCCAGAG
CAGCACCCCAATCACCTGGGCGCTGGAGGTGGCTTTGGCCCTGTAGCAGATGATGGCTAT
GGAGTTTCCTACATGATTGCAGGCGAGAACACGATCTTCTTCCACATCTCCAGCAAGTTC
TCAAGCTCAGAGACGAACGCCCAGCGCTTTGGAAACCACATCCGCAAAGCCCTGCTGGAC
ATTGCTGATCTTTTCCAAGTTCCCAAGGCCTACAGCTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
D87812

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_8_Locus:
22q13.33

# Metabolic_Enzyme_8_SNPs:
rs5770904; rs2334104; rs1804702; rs1803460; rs41309651; rs131762; rs9616791; rs28376893; rs9616868; rs11912747; rs28505118; rs9628214; rs1056964; rs1056971; rs1135081; rs11705579; rs11912521; rs12160714; rs12165562; rs12167151; rs12288; rs12330127; rs12627787; rs131745; rs131746; rs131747; rs131748; rs131749; rs131750; rs131756; rs131757; rs131758; rs131759; rs131760; rs131761; rs131766; rs131768; rs140514; rs140515; rs140516; rs140517; rs140518; rs15195; rs1557502; rs1557503; rs17001616; rs17836732; rs2073604; rs2073605; rs2269381; rs2269382; rs2269383; rs2269386; rs2269387; rs2516557; rs3213445; rs3213446; rs34744246; rs35464294; rs3752393; rs3752396; rs3810647; rs470117; rs4824130; rs5770911; rs5770913; rs5770916; rs5770917; rs6009931; rs6009932; rs6010007; rs6010012; rs6010014; rs6520156; rs7238; rs7287960; rs762676; rs762677; rs8137073; rs8137301; rs8137478; rs8141883; rs8142477; rs8142621; rs86337; rs877294; rs963980

# Metabolic_Enzyme_8_General_References:
8679700; 9344464; 9070950; 9199240; 9224698; 11258795; 10591208

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5544

# Metabolic_Enzyme_9_Name:
Carnitine O-palmitoyltransferase I, liver isoform

# Metabolic_Enzyme_9_Synonyms:
CPT I; CPTI-L; Carnitine palmitoyltransferase 1A

# Metabolic_Enzyme_9_Gene_Name:
CPT1A

# Metabolic_Enzyme_9_Protein_Sequence:
>Carnitine Opalmitoyltransferase I, liver isoform
MAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFIRFKNGIITGVYPASPS
SWLIVVVGVMTTMYAKIDPSLGIIAKINRTLETANCMSSQTKNVVSGVLFGTGLWVALIV
TMRYSLKVLLSYHGWMFTEHGKMSRATKIWMGMVKIFSGRKPMLYSFQTSLPRLPVPAVK
DTVNRYLQSVRPLMKEEDFKRMTALAQDFAVGLGPRLQWYLKLKSWWATNYVSDWWEEYI
YLRGRGPLMVNSNYYAMDLLYILPTHIQAARAGNAIHAILLYRRKLDREEIKPIRLLGST
IPLCSAQWERMFNTSRIPGEETDTIQHMRDSKHIVVYHRGRYFKVWLYHDGRLLKPREME
QQMQRILDNTSEPQPGEARLAALTAGDRVPWARCRQAYFGRGKNKQSLDAVEKAAFFVTL
DETEEGYRSEDPDTSMDSYAKSLLHGRCYDRWFDKSFTFVVFKNGKMGLNAEHSWADAPI
VAHLWEYVMSIDSLQLGYAEDGHCKGDINPNIPYPTRLQWDIPGECQEVIETSLNTANLL
ANDVDFHSFPFVAFGKGIIKKCRTSPDAFVQLALQLAHYKDMGKFCLTYEASMTRLFREG
RTETVRSCTTESCDFVRAMVDPAQTVEQRLKLFKLASEKHQHMYRLAMTGSGIDRHLFCL
YVVSKYLAVESPFLKEVLSEPWRLSTSQTPQQQVELFDLENNPEYVSSGGGFGPVADDGY
GVSYILVGENLINFHISSKFSCPETDSHRFGRHLKEAMTDIITLFGLSSNSKK

# Metabolic_Enzyme_9_Number_of_Residues:
773

# Metabolic_Enzyme_9_Molecular_Weight:
88369

# Metabolic_Enzyme_9_Theoretical_pI:
8.84

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
Palmitoyl-CoA + L-carnitine = CoA + L- palmitoylcarnitine

# Metabolic_Enzyme_9_Pathway:
map00071  Fatty acid metabolism

# Metabolic_Enzyme_9_Reaction:
palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00755:Carn_acyltransf

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
48-73
103-122

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.3.1.21

# Metabolic_Enzyme_9_GenBank_ID_Protein:
755646

# Metabolic_Enzyme_9_SwissProt_ID:
CPT1A_HUMAN (P50416)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
CPT1A

# Metabolic_Enzyme_9_Geneatlas_id:
CPT1A

# Metabolic_Enzyme_9_hgnc_id:
HGNC:2328

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; multi-pass membrane protein

# Metabolic_Enzyme_9_Gene_Sequence:
>2322 bp
ATGGCAGAAGCTCACCAAGCTGTGGCCTTTCAGTTCACGGTCACTCCGGACGGGATTGAC
CTGCGGCTGAGCCATGAAGCTCTTAGACAAATCTATCTCTCTGGACTTCATTCCTGGAAA
AAGAAGTTCATCAGATTCAAGAACGGCATCATCACTGGCGTGTACCCGGCAAGCCCCTCC
AGTTGGCTTATCGTGGTGGTGGGCGTGATGACAACGATGTACGCCAAGATCGACCCCTCG
TTAGGAATAATTGCAAAAATCAATCGGACTCTGGAAACGGCCAACTGCATGTCCAGCCAG
ACGAAGAACGTGGTCAGCGGCGTGCTGTTTGGCACCGGCCTGTGGGTGGCCCTCATCGTC
ACCATGCGCTACTCCCTGAAAGTGCTGCTCTCCTACCACGGGTGGATGTTCACTGAGCAC
GGCAAGATGAGTCGTGCCACCAAGATCTGGATGGGTATGGTCAAGATCTTTTCAGGCCGA
AAACCCATGTTGTACAGCTTCCAGACATCGCTGCCTCGCCTGCCGGTCCCGGCTGTCAAA
GACACTGTGAACAGGTATCTACAGTCGGTGAGGCCTCTTATGAAGGAAGAAGACTTCAAA
CGGATGACAGCACTTGCTCAAGATTTTGCTGTCGGTCTTGGACCAAGATTACAGTGGTAT
TTGAAGTTAAAATCCTGGTGGGCTACAAATTACGTGAGCGACTGGTGGGAGGAGTACATC
TACCTCCGAGGACGAGGGCCGCTCATGGTGAACAGCAACTATTATGCCATGGATCTGCTG
TATATCCTTCCAACTCACATTCAGGCAGCAAGAGCCGGCAACGCCATCCATGCCATCCTG
CTTTACAGGCGCAAACTGGACCGGGAGGAAATCAAACCAATTCGTCTTTTGGGATCCACG
ATTCCACTCTGCTCCGCTCAGTGGGAGCGGATGTTTAATACTTCCCGGATCCCAGGAGAG
GAGACAGACACCATCCAGCACATGAGAGACAGCAAGCACATCGTCGTGTACCATCGAGGA
CGCTACTTCAAGGTCTGGCTCTACCATGATGGGCGGCTGCTGAAGCCCCGGGAGATGGAG
CAGCAGATGCAGAGGATCCTGGACAATACCTCGGAGCCTCAGCCCGGGGAGGCCAGGCTG
GCAGCCCTCACCGCAGGAGACAGAGTTCCCTGGGCCAGGTGTCGTCAGGCCTATTTTGGA
CGTGGGAAAAATAAGCAGTCTCTTGATGCTGTGGAGAAAGCAGCGTTCTTCGTGACGTTA
GATGAAACTGAAGAAGGATACAGAAGTGAAGACCCGGATACGTCAATGGACAGCTACGCC
AAATCTCTACTACACGGCCGATGTTACGACAGGTGGTTTGACAAGTCGTTCACGTTTGTT
GTCTTCAAAAACGGGAAGATGGGCCTCAACGCTGAACACTCCTGGGCAGATGCGCAGATC
GTGGCCCACCTTTGGGAGTACGTCATGTCCATTGACAGCCTCCAGCTGGGCTATGCGGAG
GATGGGCACTGCAAAGGCGACATCAATCCGAACATTCCGTACCCCACCAGGCTGCAGTGG
GACATCCCGGGGGAATGTCAAGAGGTTATAGAGACCTCCCTGAACACCGCAAATCTTCTG
GCAAACGACGTGGATTTCCATTCCTTCCCATTCGTAGCCTTTGGTAAAGGAATCATCAAG
AAATGTCGCACGAGCCCAGACACCTTTGTGCAGCTGGCCCTCCAGCTGGCGCACTACAAG
GACATGGGCAAGTTTTGCCTCACATACGAGGCCTCCATGACCCGGCTCTTCCGAGAGGGG
AGGACGGAGACCGTGCGCTCCTGCACCACTGAGTCATGCGACTTCGTGCGGGCCATGGTG
GACCCGGCCCAGACGGTGGAACAGAGGCTGAAGTTGTTCAAGTTGGCGTCTGAGAAGCAT
CAGCATATGTATCGCCTCGCCATGACCGGCTCTGGGATCGATCGTCACCTCTTCTGCCTT
TACGTGGTGTCTAAATATCTCGCTGTGGAGTCCCCTTTCCTTAAGGAAGTTTTATCTGAG
CCTTGGAGATTATCAACAAGCCAGACCCCTCAGCAGCAAGTGGAGCTGTTTGACTTGGAG
AATAACCCAGAGTACGTGTCCAGCGGAGGGGGCTTTGGACCGGTTGCTGATGACGGCTAT
GGTGTGTCGTACATCCTTGTGGGAGAGAACCTCATCAATTTCCACATTTCTTCCAAGTTC
TCTTGCCCTGAGACGGATTCTCATCGCTTTGGAAGGCACCTGAAAGAAGCAATGACTGAC
ATCATCACTTTGTTTGGTCTCAGTTCTAATTCCAAAAAGTAA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
L39211

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_9_Locus:
11q13.1-q13.2

# Metabolic_Enzyme_9_SNPs:
rs17610395; rs2228502; rs628399; rs1017639; rs3019613; rs2924697; rs1017640; rs597539; rs11228377; rs11228372; rs3019607; rs7938117; rs3019614; rs10896371; rs3019594; rs4930614; rs11228368; rs11228374; rs2924695; rs4930617; rs1108714; rs1017641; rs643112; rs2003892; rs879784; rs4930616; rs7943745; rs10896370; rs10896369; rs12365850; rs11228373; rs644389; rs2924689; rs36105428; rs11822229; rs12361365; rs10896372; rs10792000; rs879783; rs3019611; rs613084; rs3019606; rs10459022; rs11228364; rs3019605; rs11605837; rs11228371; rs4930618; rs12283159; rs11827531; rs3019612; rs593062; rs11228376; rs11228369; rs11825726; rs11228370; rs3019608; rs7126202; rs897047; rs2123869; rs897049; rs4930610; rs3019578; rs7112896; rs7126594; rs3019587; rs1037488; rs3019598; rs7105481; rs2085062; rs7102159; rs6591353; rs3829242; rs4930248; rs3763836; rs7948344; rs732852; rs3019582; rs3794020; rs2278908; rs6591354; rs10896368; rs3763831; rs2924677; rs10791999; rs11228358; rs2305507; rs897048; rs11828477; rs2924674; rs2060981; rs11228357; rs3019597; rs2924682; rs2305508; rs1840272; rs6591355; rs747840; rs2924700; rs7942147; rs732853; rs3019603; rs4930608; rs6591356; rs3019581; rs2278906; rs11827126; rs11825304; rs4930250; rs3019604; rs3019585; rs12575292; rs11607771; rs4930247; rs11228351; rs2924687; rs11228346; rs2060980; rs4930249; rs7119078; rs11228354; rs11228341; rs7112615; rs2085063; rs4930613; rs7129243; rs2924678; rs11228359; rs2924671; rs11228349; rs12364396; rs2924675; rs3019590; rs2924685; rs11822212; rs12273177; rs4930609; rs7928089; rs10791997; rs3019576; rs7934156; rs4930612; rs2924672; rs7104634; rs7117668; rs2924679; rs3019599; rs2924683; rs3794021; rs3019584; rs7926742; rs11228350; rs3019593; rs9704703; rs2924692; rs2278907; rs10791998; rs3763830; rs597316; rs7131462; rs4584583; rs3922501; rs1046804; rs41302429; rs11228356; rs3019610; rs12364665; rs12283670; rs583914; rs641302; rs34727673; rs5792455; rs34595037; rs35634010; rs11228375; rs34794325; rs12364259; rs7482525; rs34314249; rs11418561; rs12272547; rs35006871; rs34763278; rs35467950; rs5792454; rs12801913; rs4930619; rs35195021; rs12793416; rs11828395; rs10633712; rs593064; rs35472359; rs35234753; rs34854628; rs12364691; rs34758497; rs3019609; rs12283783; rs12283727; rs11821979; rs34429633; rs12292255; rs35819630; rs34404058; rs12290497; rs2924691; rs7480689; rs11228367; rs12788142; rs35586360; rs10688362; rs36108814; rs2924696; rs34656095; rs3019615; rs12283144; rs35627517; rs35518321; rs12290326; rs34175092; rs12803116; rs35820230; rs36211044; rs673059; rs11228379; rs2924694; rs12283786; rs641304; rs7483929; rs11372679; rs5792452; rs609983; rs12283787; rs35956171; rs656569; rs11228363; rs35029230; rs1993277; rs2924690; rs34222279; rs12272381; rs34106250; rs34882695; rs34752141; rs35428930; rs35190628; rs11228378; rs28706864; rs12290603; rs12793100; rs2924698; rs11821572; rs35786597; rs17848444; rs36037833; rs34772073; rs35269495; rs34276531; rs897046; rs34480858; rs5792453; rs36030703; rs4261294; rs35703107; rs17848445; rs4408320; rs11228361; rs17848452; rs33981601; rs12421861; rs41302431; rs10551845; rs11827064; rs5792450; rs2924670; rs3019595; rs36152240; rs1809153; rs10614870; rs12225347; rs12788900; rs34450025; rs11312962; rs10561732; rs7944039; rs17848449; rs10160644; rs11301758; rs1840273; rs34991663; rs12277917; rs11416327; rs11420370; rs12293710; rs12416862; rs12808840; rs35804809; rs2924681; rs12274770; rs2375867; rs36010265; rs35948154; rs35597245; rs3019596; rs35593953; rs35803657; rs12808833; rs34326931; rs2924684; rs11823947; rs12790880; rs7942391; rs10591978; rs34884968; rs10676288; rs35999790; rs11311321; rs12802903; rs35099183; rs12282676; rs11306055; rs33977467; rs5792451; rs10561780; rs35513013; rs3019577; rs2924680; rs11228345; rs3019591; rs12363334; rs11228340; rs3019602; rs11443873; rs4930611; rs3019601; rs11365149; rs3763834; rs35497430; rs35857185; rs11601427; rs3019575; rs11328803; rs10590789; rs7948837; rs35232106; rs11228348; rs10160686; rs7951987; rs10657961; rs7925592; rs35033163; rs2924699; rs11228353; rs11419131; rs2924693; rs17848439; rs3019592; rs34829139; rs2924688; rs7924951; rs2278905; rs11311322; rs3083118; rs33998161; rs35483425; rs3019580; rs3019600; rs2060979; rs34370352; rs35967738; rs11400593; rs3019579; rs35816594; rs35947002; rs11376032; rs35323274; rs11228343; rs35574171; rs11413406; rs11423981; rs17848451; rs3763835; rs35363406; rs17848446; rs34324238; rs7943886; rs2924676; rs11826977; rs34100447; rs1840271; rs3083115; rs34518934; rs34605091; rs11228352; rs35591039; rs34325048; rs11228342; rs7108728; rs11333511; rs7111658; rs35809934; rs11323138; rs35401315; rs11228362; rs34756817; rs12808271; rs12808487; rs34198180; rs3018712; rs35128171; rs35985228; rs10791994; rs10896364; rs10896365; rs11825731; rs12365708; rs2060982; rs2508848; rs3019583; rs36118833; rs483148; rs4930606; rs678904; rs679596; rs7110940; rs7941385; rs7948522

# Metabolic_Enzyme_9_General_References:
7892212

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
6117

# Metabolic_Enzyme_10_Name:
Glycerol kinase

# Metabolic_Enzyme_10_Synonyms:
ATP:glycerol 3-phosphotransferase; Glycerokinase; GK

# Metabolic_Enzyme_10_Gene_Name:
GK

# Metabolic_Enzyme_10_Protein_Sequence:
>Glycerol kinase
MAASKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEI
LHSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKITGEPLYNAVVWLDLRTQ
STVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEKRALFGTIDS
WLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKQLCEFFGIPMEILPNVRSSSEIY
GLMKAGALEGVPISGCLGDQSAALVGQMCFQIGQAKNTYGTGCFLLCNTGHKCVFSDHGL
LTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKTSEEIEKLAKEVGTSYGCYF
VPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLS
HLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLS
AVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSPESGIP

# Metabolic_Enzyme_10_Number_of_Residues:
524

# Metabolic_Enzyme_10_Molecular_Weight:
57490

# Metabolic_Enzyme_10_Theoretical_pI:
6.25

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  glycerol kinase activity
 ||
>>>
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  polyol metabolism
Process:  glycerol metabolism
Process:  glycerol-3-phosphate metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_10_Specific_Function:
Key enzyme in the regulation of glycerol uptake and metabolism

# Metabolic_Enzyme_10_Pathway:
map00561  Glycerolipid metabolism

# Metabolic_Enzyme_10_Reaction:
ATP + glycerol = ADP + sn-glycerol 3-phosphate

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF02782:FGGY_C;
PF00370:FGGY_N

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.7.1.30

# Metabolic_Enzyme_10_GenBank_ID_Protein:
348167

# Metabolic_Enzyme_10_SwissProt_ID:
GLPK_HUMAN (P32189)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
GK

# Metabolic_Enzyme_10_Geneatlas_id:
GK

# Metabolic_Enzyme_10_hgnc_id:
HGNC:4289

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; peripheral membrane protein; cytoplasmic side. Cytoplasm. Note=In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm

# Metabolic_Enzyme_10_Gene_Sequence:
>1575 bp
ATGGCAGCCTCAAAGAAGGCAGTTTTGGGGCCATTGGTGGGGGCGGTGGACCAGGGCACC
AGTTCGACGCGCTTTTTGGTTTTCAATTCAAAAACAGCTGAACTACTTAGTCATCATCAA
GTAGAAATAAAACAAGAGTTCCCAAGAGAAGGATGGGTGGAACAGGACCCTAAGGAAATT
CTACATTCTGTCTATGAGTGTATAGAGAAAACATGTGAGAAACTTGGACAGCTCAATATT
GATATTTCCAACATAAAAGCTATTGGTGTCAGCAACCAGAGGGAAACCACTGTAGTCTGG
GACAAGATAACTGGAGAGCCTCTCTACAATGCTGTGGTGTGGCTTGATCTAAGAACCCAG
TCTACCGTTGAGAGTCTTAGTAAAAGAATTCCAGGAAATAATAACTTTGTCAAGTCCAAG
ACAGGCCTTCCACTTAGCACTTACTTCAGTGCAGTGAAACTTCGTTGGCTCCTTGACAAT
GTGAGAAAAGTTCAAAAGGCCGTTGAAGAAAAACGAGCTCTTTTTGGGACTATTGATTCA
TGGCTTATTTGGAGTTTGACAGGAGGAGTCAATGGAGGTGTCCACTGTACAGATGTAACA
AATGCAAGTAGGACTATGCTTTTCAACATTCATTCTTTGGAATGGGATAAACAACTCTGC
GAATTTTTTGGAATTCCAATGGAAATTCTTCCAAATGTCCGGAGTTCTTCTGAGATCTAT
GGCCTAATGAAAGCTGGGGCCTTGGAAGGTGTGCCAATATCTGGGTGTTTAGGGGACCAG
TCTGCTGCATTGGTGGGACAAATGTGCTTCCAGATTGGACAAGCCAAAAATACGTATGGA
ACAGGATGTTTCTTACTATGTAATACAGGCCATAAGTGTGTATTTTCTGATCATGGCCTT
CTCACCACAGTGGCTTACAAACTTGGCAGAGACAAACCAGTATATTATGCTTTGGAAGGT
TCTGTAGCTATAGCTGGTGCTGTTATTCGCTGGCTAAGAGACAATCTTGGAATTATAAAG
ACCTCAGAAGAAATTGAAAAACTTGCTAAAGAAGTAGGTACTTCTTATGGCTGCTACTTC
GTCCCAGCATTTTCGGGGTTATATGCACCTTATTGGGAGCCCAGCGCAAGAGGGATAATC
TGTGGACTCACTCAGTTCACCAATAAATGCCATATTGCTTTTGCTGCATTAGAAGCTGTT
TGTTTCCAAACTCGAGAGATTTTGGATGCCATGAATCGAGACTGTGGAATTCCACTCAGT
CATTTGCAGGTAGATGGAGGAATGACCAGCAACAAAATTCTTATGCAGCTACAAGCAGAC
ATTCTGTATATACCAGTAGTGAAGCCCTCAATGCCCGAAACCACTGCACTGGGTGCGGCT
ATGGCGGCAGGGGCTGCAGAAGGAGTCGGCGTATGGAGTCTCGAACCCGAGGATTTGTCT
GCCGTCACGATGGAGCGGTTTGAACCTCAGATTAATGCGGAGGAAAGTGAAATTCGTTAT
TCTACATGGAAGAAAGCTGTGATGAAGTCAATGGGTTGGGTTACAACTCAATCTCCAGAA
AGTGGTATTCCATAA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
L13943

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_10_Locus:
Xp21.3

# Metabolic_Enzyme_10_SNPs:
rs17854202; rs34795481; rs5926945; rs1803659; rs5972222; rs931240; rs5927582; rs6527003; rs619; rs728149; rs4636357; rs12844553; rs4487947; rs6527002; rs5972211; rs5927593; rs1482834; rs6526991; rs5927587; rs6526997; rs5927596; rs5927584; rs4077820; rs12843585; rs967785; rs5927589; rs5972207; rs4609338; rs12560212; rs6526996; rs5926944; rs5927595; rs2868571; rs5926942; rs5972213; rs2035432; rs620; rs12854653; rs12011728; rs16989176; rs1871965; rs7058925; rs7878037; rs5927585; rs16989169; rs5927594; rs6526995; rs5972206; rs6631156; rs12010068; rs4617310; rs12007993; rs5972204; rs5971513; rs12851094; rs5972202; rs7879845; rs2035431; rs4345726; rs5972203; rs12557274; rs5927588; rs12009986; rs5927590; rs5926943; rs5927581; rs5927599; rs2170611; rs11095189; rs17854203; rs17857267; rs5927597; rs5972217; rs5972215; rs5927598; rs5972216; rs5926946; rs3931219; rs5972219; rs34867477; rs5972221; rs5972220; rs5972218; rs41302637; rs34792758; rs35918035; rs35586363; rs36091656; rs41305205; rs34365099; rs10644351; rs4829198; rs5971511; rs34992170; rs41311819; rs34773549; rs6631159; rs35313243; rs34172820; rs35124133; rs6631151; rs10682299; rs6631142; rs34474761; rs35688593; rs35784640; rs5927591; rs35182768; rs5927580; rs28366724; rs35849427; rs34275810; rs12847609; rs6631141; rs6628544; rs5971512; rs35027105; rs5927586; rs6631158; rs5926938; rs35498618; rs35856351; rs5926941; rs6631155; rs10656820; rs35354095; rs35120364; rs5927592; rs35987506; rs35931680; rs4415475; rs11281728; rs5926940; rs11306027; rs6631140; rs34129824; rs35468110; rs12007023; rs28697906; rs6631157; rs6631144; rs35791116; rs5972209; rs28390198; rs41309689; rs34160985; rs5926939; rs35547075; rs3838210; rs41311491; rs12843247; rs12845821; rs35183149; rs35290317; rs12007026; rs3747459; rs5972210; rs5972205; rs11282593; rs6631143; rs11349869; rs36091714; rs34474103; rs6631161; rs34088900; rs12007087; rs6631146; rs11417266; rs35182714; rs12862589; rs34301411; rs36133772; rs12844258; rs11461651; rs12011679; rs4486355; rs6631150; rs11400828; rs34773915; rs3838209; rs34462788; rs12007053; rs2868570; rs5927606; rs5927607; rs5972224; rs6526989; rs6527012; rs6653843; rs7049882

# Metabolic_Enzyme_10_General_References:
8401584; 7987308; 8499912; 8499898; 8651297; 9719371; 10736265

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
6066

# Metabolic_Enzyme_11_Name:
Alcohol dehydrogenase 1C

# Metabolic_Enzyme_11_Synonyms:
Alcohol dehydrogenase gamma subunit

# Metabolic_Enzyme_11_Gene_Name:
ADH1C

# Metabolic_Enzyme_11_Protein_Sequence:
>Alcohol dehydrogenase 1
CMSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLV
TPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGN
PRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFST
GYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGAT
ECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDS
QNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNILPFEKINEG
FDLLRSGKSIRTVLTF

# Metabolic_Enzyme_11_Number_of_Residues:
375

# Metabolic_Enzyme_11_Molecular_Weight:
39868

# Metabolic_Enzyme_11_Theoretical_pI:
8.38

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_11_Specific_Function:
An alcohol + NAD(+) = an aldehyde or ketone + NADH

# Metabolic_Enzyme_11_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_11_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_11_GenBank_ID_Protein:
28404

# Metabolic_Enzyme_11_SwissProt_ID:
ADH1G_HUMAN (P00326)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
ADH1C

# Metabolic_Enzyme_11_Geneatlas_id:
ADH1C

# Metabolic_Enzyme_11_hgnc_id:
HGNC:251

# Metabolic_Enzyme_11_PDB_ID:
1HT0

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_11_Gene_Sequence:
>1128 bp
ATGAGCACAGCAGGAAAAGTAATCAAATGCAAAGCAGCTGTGCTATGGGAGTTAAAGAAA
CCCTTTTCCATTGAGGAGGTAGAGGTTGCACCTCCTAAGGCTCATGAAGTTCGCATTAAG
ATGGTGGCTGCAGGAATCTGTCGTTCAGATGAGCATGTGGTTAGTGGCAACCTGGTGACC
CCCCTTCCTGTGATTTTAGGCCATGAGGCAGCCGGCATCGTGGAAAGTGTTGGAGAAGGG
GTGACTACAGTCAAACCAGGTGATAAAGTCATCCCGCTCTTTACTCCTCAGTGTGGAAAA
TGCAGAATTTGCAAAAACCCAGAAAGCAACTACTGCTTGAAAAATGATCTAGGCAATCCT
CGGGGGACCCTGCAGGATGGCACCAGGAGGTTCACCTGCAGCGGGAAGCCCATCCACCAC
TTCGTCGGCGTCAGCACCTTCTCCCAGTACACAGTGGTGGATGAGAATGCAGTAGCCAAA
ATTGATGCAGCCTCGCCCCTGGAGAAAGTCTGCCTCATTGGCTGTGGATTTTCGACTGGT
TATGGGTCTGCAGTCAAAGTTGCCAAGGTCACCCCAGGGTCTACCTGTGCTGTGTTTGGC
CTGGGAGGGGTCGGCCTATCTGTTGTTATGGGCTGTAAAGCAGCTGGAGCAGCCAGAATC
ATTGCTGTGGACATCAACAAGGACAAATTTGCAAAGGCTAAAGAGTTGGGTGCCACTGAA
TGCATCAACCCTCAAGACTACAAGAAACCCATTCAGGAAGTGCTAAAGGAAATGACTGAT
GGAGGTGTGGATTTTTCGTTTGAAGTCATCGGTCAGCTTGACACCATGATGGCTTCCCTG
TTATGTTGTCATGAGGCATGTGGCACAAGTGTCATTGTAGGGGTACCTCCTGATTCCCAG
AACCTCTCAATAAACCCTATGCTGCTACTGACTGGACGCACGTGGAAAGGAGCTATTTTT
GGAGGCTTTAAGAGTAAAGAATCTGTCCCCAAACTTGTGGCTGACTTTATGGCTAAGAAG
TTTTCACTGGATGCATTAATAACAAATGTTTTACCTTTTGAAAAAATAAATGAAGGATTT
GACCTGCTTCGCTCTGGAAAGAGTATCCGTACCGTCCTGACGTTTTGA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
X04299

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_11_Locus:
4q21-q23

# Metabolic_Enzyme_11_SNPs:
rs35385902; rs35719513; rs1693482; rs698; rs2241894; rs6413444; rs1042756; rs1693425; rs1789915; rs2298753; rs1391088; rs904096; rs1789911; rs1614972; rs1789898; rs1612735; rs1789921; rs3762896; rs3846449; rs283415; rs4147542; rs1789910; rs3133158; rs11936869; rs1789912; rs1442481; rs33988198; rs17586023; rs1662058; rs1662051; rs1789908; rs2298755; rs17526590; rs1789903; rs1662048; rs1789900; rs1662057; rs1693481; rs904095; rs6846835; rs1662060; rs1789920; rs6413446; rs1662049; rs1693480; rs6532815; rs1442479; rs1693427; rs35429031; rs1693453; rs13125415; rs1693476; rs6413447; rs12650330; rs1789901; rs35862892; rs3114047; rs1693471; rs283409; rs34009511; rs1662047; rs2009181; rs1789923; rs35500540; rs6413445; rs35189763; rs36050634; rs1789902; rs1693428; rs1625439; rs3114048; rs283411; rs34178057; rs34484723; rs6413448; rs35408712; rs35799067; rs283410; rs34250750; rs34551784; rs1662052; rs1662033; rs1662059; rs1662045; rs34736030; rs34664835; rs1693426; rs1442480; rs1693431; rs1789904; rs3910713; rs1693424; rs12639833; rs1662053; rs1693477; rs35221936; rs34871400; rs283416; rs1662046; rs34317813; rs34761493; rs2866153; rs1631460; rs904094; rs1693454; rs1789896; rs3114046; rs1229979; rs3098808; rs1662031; rs11499825; rs1789924; rs17028860; rs11499824; rs17586163; rs11499823; rs35963940; rs1693468; rs4147541; rs1789925; rs34436992; rs36024187; rs2584453; rs35365756; rs1629838; rs1789895; rs35478916; rs35614967; rs1693469; rs1229978; rs283413; rs34195308; rs35725608; rs2132839; rs2851298; rs1789919; rs36019411; rs1693483; rs6834363; rs34427956; rs35124782; rs33982136; rs904093; rs35088274; rs7658726; rs2298754; rs1662055; rs35191371; rs34918164; rs1789905; rs3133157; rs35090494; rs35470995; rs34661405; rs13118501; rs1693456; rs35418122; rs34057349; rs2903199; rs36052336; rs2851299; rs13118443; rs3216150; rs1975438; rs13147169; rs35920708; rs1662056; rs34579771; rs1789917; rs34804188; rs1789906; rs2132838; rs35081954; rs13147189; rs35381492; rs1693430; rs1693429; rs1693474; rs3960879; rs10634918; rs35735210; rs6148597; rs34782639; rs1629270; rs283414; rs1789914; rs1789916; rs35733876; rs34936799; rs35420886; rs34379379; rs1662035; rs6148596; rs283412; rs172223; rs1789913; rs5860576; rs35801274; rs34480181; rs3098809; rs35293095; rs1662030; rs36095748; rs34774688; rs1662032; rs35691997; rs35978141; rs34328535; rs34484557; rs1154432; rs1154433; rs1229851; rs1229852; rs1229853; rs1229854; rs1229863; rs1229864; rs1229980; rs1614377; rs1662037; rs1662039; rs166892; rs1693470; rs17586246; rs1789890; rs1789891; rs2584455; rs2851300; rs2866152; rs4699741; rs980972

# Metabolic_Enzyme_11_General_References:
3758060; 2935875; 1524834; 6391921

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5320

# Metabolic_Enzyme_12_Name:
Aldose reductase

# Metabolic_Enzyme_12_Synonyms:
AR; Aldehyde reductase

# Metabolic_Enzyme_12_Gene_Name:
AKR1B1

# Metabolic_Enzyme_12_Protein_Sequence:
>Aldose reductase
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF

# Metabolic_Enzyme_12_Number_of_Residues:
316

# Metabolic_Enzyme_12_Molecular_Weight:
35854

# Metabolic_Enzyme_12_Theoretical_pI:
6.99

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Not Available

# Metabolic_Enzyme_12_Specific_Function:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies

# Metabolic_Enzyme_12_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism

# Metabolic_Enzyme_12_Reaction:
alditol + NAD(P)+ = aldose + NAD(P)H + H+

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_12_Signals:
None

# Metabolic_Enzyme_12_Transmembrane_Regions:
None

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 1.1.1.21

# Metabolic_Enzyme_12_GenBank_ID_Protein:
178487

# Metabolic_Enzyme_12_SwissProt_ID:
ALDR_HUMAN (P15121)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
AKR1B1

# Metabolic_Enzyme_12_Geneatlas_id:
AKR1B1

# Metabolic_Enzyme_12_hgnc_id:
HGNC:381

# Metabolic_Enzyme_12_PDB_ID:
1T40

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_12_Gene_Sequence:
>951 bp
ATGGCAAGCCGTCTCCTGCTCAACAACGGCGCCAAGATGCCCATCCTGGGGTTGGGTACC
TGGAAGTCCCCTCCAGGGCAGGTGACTGAGGCCGTGAAGGTGGCCATTGACGTCGGGTAC
CGCCACATCGACTGTGCCCATGTGTACCAGAATGAGAATGAGGTGGGGGTGGCCATTCAG
GAGAAGCTCAGGGAGCAGGTGGTGAAGCGTGAGGAGCTCTTCATCGTCAGCAAGCTGTGG
TGCACGTACCATGAGAAGGGCCTGGTGAAAGGAGCCTGCCAGAAGACACTCAGCGACCTG
AAGCTGGACTACCTGGACCTCTACCTTATTCACTGGCCGACTGGCTTTAAGCCTGGGAAG
GAATTTTTCCCATTGGATGAGTCGGGCAATGTGGTTCCCAGTGACACCAACATTCTGGAC
ACGTGGGCGGCCATGGAAGAGCTGGTGGATGAAGGGCTGGTGAAAGCTATTGGCATCTCC
AACTTCAACCATCTCCAGGTGGAGATGATCTTAAACAAACCTGGCTTGAAGTATAAGCCT
GCAGTTAACCAGATTGAGTGCCACCCATATCTCACTCAGGAGAAGTTAATCCAGTACTGC
CAGTCCAAAGGCATCGTGGTGACCGCCTACAGCCCCCTCGGCTCTCCTGACAGGCCCTGG
GCCAAGCCCGAGGACCCTTCTCTCCTGGAGGATCCCAGGATCAAGGCGATCGCAGCCAAG
CACAATAAAACTACAGCCCAGGTCCTGATCCGGTTCCCCATGCAGAGGAACTTGGTGGTG
ATCCCCAAGTCTGTGACACCAGAACGCATTGCTGAGAACTTTAAGGTCTTTGACTTTGAA
CTGAGCAGCCAGGATATGACCACCTTACTCAGCTACAACAGGAACTGGAGGGTCTGTGCC
TTGTTGAGCTGTACCTCCCACAAGGATTACCCCTTCCATGAAGAGTTTTGA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
J04795

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_12_Locus:
7q35

# Metabolic_Enzyme_12_SNPs:
rs5054; rs5060; rs5059; rs2229543; rs3087630; rs5055; rs5053; rs1790999; rs1790998; rs1646640; rs4732027; rs2734653; rs3896278; rs2734650; rs10954455; rs1708432; rs10808275; rs17660462; rs2670227; rs11974100; rs2734657; rs2670232; rs1424426; rs2734649; rs2551472; rs2259458; rs17188118; rs12669537; rs2734655; rs7778371; rs1708434; rs11971263; rs2670230; rs10273906; rs17167854; rs2734665; rs969309; rs2701020; rs2734663; rs2734664; rs706207; rs759853; rs17167851; rs918825; rs918824; rs11975656; rs17856148; rs11544687; rs5057; rs4728325; rs5061; rs5062; rs5056; rs17849987; rs1803093; rs3210035; rs11544690; rs13306160; rs1803094; rs1803095; rs2852171; rs2854854; rs2551469; rs3749434; rs2734661; rs2670231; rs2551471; rs1791000; rs2670240; rs2734659; rs2852165; rs2551476; rs3216672; rs2854849; rs7801237; rs2269068; rs10588800; rs35880193; rs2734658; rs34559471; rs2691837; rs1732035; rs2852170; rs2854853; rs2670239; rs1646639; rs2854851; rs5058; rs2551470; rs2670233; rs13306159; rs2854848; rs2701019; rs2734660; rs1732037; rs2852164; rs11417418; rs35431624; rs2852163; rs2269069; rs35632302; rs2852173; rs2854850; rs2551473; rs35338055; rs2691840; rs2852172; rs2734652; rs2852167; rs2854852; rs6963238; rs1791006; rs34569487; rs2670229; rs2551475; rs2691838; rs13306161; rs3216673; rs2974975; rs2551474; rs34678793; rs2551467; rs33945153; rs2852169; rs2734656; rs2854846; rs2734651; rs2691839; rs2734662; rs2852166; rs2691841; rs2551468; rs2691835; rs2551477; rs2691836; rs13306162; rs1708427; rs2852168; rs2670226; rs1621922; rs2852174; rs2551465; rs2691845; rs2551466; rs918826; rs35706999; rs2852176; rs2691846; rs1708404; rs12532832; rs1732039; rs1646636; rs1646642; rs1646637; rs2852175; rs1646641; rs10228986; rs10236262; rs10236468; rs10241645; rs10244489; rs10252030; rs10263438; rs10275865; rs11973239; rs13225343; rs1708414; rs1708415; rs1708416; rs17167841; rs1722900; rs1722911; rs1732038; rs1791001; rs2347375; rs2670228; rs6977866; rs706206; rs7802421; rs782054

# Metabolic_Enzyme_12_General_References:
2498333; 2504709; 2510130; 2111143; 2112546; 1901857; 9195951; 8435445; 2492527; 8343525; 8281941; 8245005; 1621098; 1447221; 8234324; 9405046

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5547

# Metabolic_Enzyme_13_Name:
Carnitine O-palmitoyltransferase I, brain isoform

# Metabolic_Enzyme_13_Synonyms:
Carnitine palmitoyltransferase 1C; CPT IC

# Metabolic_Enzyme_13_Gene_Name:
CPT1C

# Metabolic_Enzyme_13_Protein_Sequence:
>Carnitine Opalmitoyltransferase I, brain isoform
MAEAHQAVGFRPSLTSDGAEVELSAPVLQEIYLSGLRSWKRHLSRFWNDFLTGVFPASPL
SWLFLFSAIQLAWFLQLDPSLGLMEKIKELLPDWGGQHHGLRGVLAAALFASCLWGALIF
TLHVALRLLLSYHGWLLEPHGAMSSPTKTWLALVRIFSGRHPMLFSYQRSLPRQPVPSVQ
DTVRKYLESVRPILSDEDFDWTAVLAQEFLRLQASLLQWYLRLKSWWASNYVSDWWEEFV
YLRSRNPLMVNSNYYMMDFLYVTPTPLQAARAGNAVHALLLYRHRLNRQEIPPTLLMGMR
PLCSAQYEKIFNTTRIPGVQKDYIRHLHDSQHVAVFHRGRFFRMGTHSRNSLLSPRALEQ
QFQRILDDPSPACPHEEHLAALTAAPRGTWAQVRTSLKTQAAEALEAVEGAAFFVSLDAE
PAGLTREDPAASLDAYAHALLAGRGHDRWFDKSFTLIVFSNGKLGLSVEHSWADCPISGH
MWEFTLATECFQLGYSTDGHCKGHPDPTLPQPQRLQWDLPDQIHSSISLALRGAKILSEN
VDCHVVPFSLFGKSFIRRCHLSSDSFIQIALQLAHFRDRGQFCLTYESAMTRLFLEGRTE
TVRSCTREACNFVRAMEDKEKTDPQCLALFRVAVDKHQALLKAAMSGQGVDRHLFALYIV
SRFLHLQSPFLTQVHSEQWQLSTSQIPVQQMHLFDVHNYPDYVSSGGGFGPADDHGYGVS
YIFMGDGMITFHISSKKSSTKTDSHRLGQHIEDALLDVASLFQAGQHFKRRFRGSGKENS
RHRCGFLSRQTGASKASMTSTDF

# Metabolic_Enzyme_13_Number_of_Residues:
803

# Metabolic_Enzyme_13_Molecular_Weight:
90990

# Metabolic_Enzyme_13_Theoretical_pI:
8.18

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Not Available

# Metabolic_Enzyme_13_Specific_Function:
Palmitoyl-CoA + L-carnitine = CoA + L- palmitoylcarnitine

# Metabolic_Enzyme_13_Pathway:
map00071  Fatty acid metabolism

# Metabolic_Enzyme_13_Reaction:
palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF00755:Carn_acyltransf

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
53-75
104-126

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 2.3.1.21

# Metabolic_Enzyme_13_GenBank_ID_Protein:
19850304

# Metabolic_Enzyme_13_SwissProt_ID:
CPT1C_HUMAN (Q8TCG5)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
CPT1C

# Metabolic_Enzyme_13_Geneatlas_id:
CPT1C

# Metabolic_Enzyme_13_hgnc_id:
HGNC:18540

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; multi-pass membrane protein

# Metabolic_Enzyme_13_Gene_Sequence:
>114 bp
ATGCAAGCGGGAGATTTGGGGCCGGCGCTCAAAATCGGGGGGCGGGGGTGGACTCGGGTT
TGGACCCCAGGATCCGATCAGCGGACCCTTGATTCAACGTGGGCTCCAGCGTGA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
AF357970

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_13_Locus:
19q13.33

# Metabolic_Enzyme_13_SNPs:
rs12978911; rs892149; rs7249356; rs10417008; rs12977028; rs10407097; rs10416103; rs12984428; rs12980063; rs12462023; rs12973371; rs11881828; rs8105199; rs721885; rs8103273; rs12981033; rs12980899; rs10415869; rs12984268; rs12463356; rs1075453; rs1053765; rs12973248; rs892150; rs4991337; rs12977747; rs12462954; rs12973628; rs7255621; rs12977052; rs12983758; rs28609199; rs12982265; rs12981341; rs2008744; rs10683852; rs35816232; rs12977188; rs12978983; rs12977862; rs10401426; rs12462996; rs12976001; rs10404778; rs12980876; rs35851238; rs11438801; rs34040497; rs8109119; rs34296413; rs11361908; rs12974776; rs9797664; rs35318539; rs34325070; rs12973369; rs11878355; rs2008725; rs34561432; rs721883; rs10406861; rs12982733; rs12981124; rs34827529; rs12983747; rs12462937; rs2008125; rs7246934; rs12610653; rs34974547; rs10423579; rs10609652; rs12974810; rs12973329; rs12982459; rs34722696; rs11671797; rs11666611; rs35013089; rs10421227; rs34770546; rs12982737; rs10415076; rs12976936; rs2005152; rs12985728; rs12977128; rs10423580; rs34948913; rs34556306; rs35925219; rs12462936; rs12984650; rs34378890; rs11879194; rs12977140; rs12977472; rs10415880; rs10425688; rs1128424; rs12462259; rs1804486; rs2288919; rs35270176; rs3745468; rs3816047; rs7260179

# Metabolic_Enzyme_13_General_References:
12376098

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5601

# Metabolic_Enzyme_14_Name:
Lactase-phlorizin hydrolase precursor

# Metabolic_Enzyme_14_Synonyms:
Lactase-glycosylceramidase[Includes: Lactase

# Metabolic_Enzyme_14_Gene_Name:
LCT

# Metabolic_Enzyme_14_Protein_Sequence:
>Lactasephlorizin hydrolase precursor
MELSWHVVFIALLSFSCWGSDWESDRNFISTAGPLTNDLLHNLSGLLGDQSSNFVAGDKD
MYVCHQPLPTFLPEYFSSLHASQITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKAL
KTARLQPMVILHHQTLPASTLRRTEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIK
ELPHQESRASQLQTLSDAHRKAYEIYHESYAFQGGKLSVVLRAEDIPELLLEPPISALAQ
DTVDFLSLDLSYECQNEASLRQKLSKLQTIEPKVKVFIFNLKLPDCPSTMKNPASLLFSL
FEAINKDQVLTIGFDINEFLSCSSSSKKSMSCSLTGSLALQPDQQQDHETTDSSPASAYQ
RVWEAFANQSRAERDAFLQDTFPEGFLWGASTGAFNVEGGWAEGGRGVSIWDPRRPLNTT
EGQATLEVASDSYHKVASDVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKL
IDRLQDAGIEPMATLFHWDLPQALQDHGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTF
HEPWVMSYAGYGTGQHPPGISDPGVASFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIV
LNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFVDGDYPATLRTQIQQMNRQCSHPV
AQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQHVNHVWPQT
SSSWIRVVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYIN
EVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTS
IIEKNGFLTKGAKRLLPPNTVNLPSKVRAFTFPSEVPSKAKVVWEKFSSQPKFERDLFYH
GTFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLD
ADLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFH
WDLPQALQDIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFP
PGVKDPGWAPYRIAHTVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDV
EAADRMLQFSLGWFAHPIFRNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRAT
ADVFCLNTYYSRIVQHKTPRLNPPSYEDDQEMAEEEDPSWPSTAMNRAAPWGTRRLLNWI
KEEYGDIPIYITENGVGLTNPNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWSLMD
NFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMPLAREDEFLYGRFPEG
FIWSAASAAYQIEGAWRADGKGLSIWDTFSHTPLRVENDAIGDVACDSYHKIAEDLVTLQ
NLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHWDLPQTL
QDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTAAPGVSNRP
GTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSNQEDVEAARRY
VQFMGGWFAHPIFKNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRINGTYDFFGF
NHYTTVLAYNLNYATAISSFDADRGVASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEY
NDPPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEW
ATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPDPATGPHACLHQPDAGPTI
SPVRQEEVQFLGLMLGTTEAQTALYVLFSLVLLGVCGLAFLSYKYCKRSKQGKTQRSQQE
LSPVSSF

# Metabolic_Enzyme_14_Number_of_Residues:
1927

# Metabolic_Enzyme_14_Molecular_Weight:
218604

# Metabolic_Enzyme_14_Theoretical_pI:
6.30

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  glucosidase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
LPH splits lactose in the small intestine

# Metabolic_Enzyme_14_Pathway:
map00052  Galactose metabolism

# Metabolic_Enzyme_14_Reaction:
lactose + H2O = D-galactose + D-glucose

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00232:Glyco_hydro_1

# Metabolic_Enzyme_14_Signals:
1-19

# Metabolic_Enzyme_14_Transmembrane_Regions:
1883-1901

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 3.2.1.108;EC 3.2.1.62

# Metabolic_Enzyme_14_GenBank_ID_Protein:
34400

# Metabolic_Enzyme_14_SwissProt_ID:
LPH_HUMAN (P09848)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
LCT

# Metabolic_Enzyme_14_Geneatlas_id:
LCT

# Metabolic_Enzyme_14_hgnc_id:
HGNC:6530

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Cell membrane; apical cell membrane; single- pass type I membrane protein. Note=Brush border

# Metabolic_Enzyme_14_Gene_Sequence:
>5784 bp
ATGGAGCTGTCTTGGCATGTAGTCTTTATTGCCCTGCTAAGTTTTTCATGCTGGGGGTCA
GACTGGGAGTCTGATAGAAATTTCATTTCCACCGCTGGTCCTCTAACCAATGACTTGCTG
CACAACCTGAGTGGTCTCCTGGGAGACCAGAGTTCTAACTTTGTAGCAGGGGACAAAGAC
ATGTATGTTTGTCACCAGCCACTGCCCACTTTCCTGCCAGAATACTTCAGCAGTCTCCAT
GCCAGTCAGATCACCCATTATAAGGTATTTCTGTCATGGGCACAGCTCCTCCCAGCAGGA
AGCACCCAGAATCCAGACGAGAAAACAGTGCAGTGCTACCGGCGACTCCTCAAGGCCCTC
AAGACTGCACGGCTTCAGCCCATGGTCATCCTGCACCACCAGACCCTCCCTGCCAGCACC
CTCCGGAGAACCGAAGCCTTTGCTGACCTCTTCGCCGACTATGCCACATTCGCCTTCCAC
TCCTTCGGGGACCTAGTTGGGATCTGGTTCACCTTCAGTGACTTGGAGGAAGTGATCAAG
GAGCTTCCCCACCAGGAATCAAGAGCGTCACAACTCCAGACCCTCAGTGATGCCCACAGA
AAAGCCTATGAGATTTACCACGAAAGCTATGCTTTTCAGGGCGGAAAACTCTCTGTTGTC
CTGCGAGCTGAAGATATCCCGGAGCTCCTGCTAGAACCACCCATATCTGCGCTTGCCCAG
GACACGGTCGATTTCCTCTCTCTTGATTTGTCTTATGAATGCCAAAATGAGGCAAGTCTG
CGGCAGAAGCTGAGTAAATTGCAGACCATTGAGCCAAAAGTGAAAGTTTTCATCTTCAAC
CTAAAACTCCCAGACTGCCCCTCCACCATGAAGAACCCAGCCAGTCTGCTCTTCAGCCTT
TTTGAAGCCATAAATAAAGACCAAGTGCTCACCATTGGGTTTGATATTAATGAGTTTCTG
AGTTGTTCATCAAGTTCCAAGAAAAGCATGTCTTGTTCTCTGACTGGCAGCCTGGCCCTT
CAGCCTGACCAGCAGCAGGACCACGAGACCACGGACTCCTCTCCTGCCTCTGCCTATCAG
AGAGTCTGGGAAGCATTTGCCAATCAGTCCAGAGCGGAAAGGGATGCCTTCCTGCAGGAT
ACTTTCCCTGAAGGCTTCCTCTGGGGTGCCTCCACAGGAGCCTTTAACGTGGAAGGAGGC
TGGGCCGAGGGTGGGAGAGGGGTGAGCATCTGGGATCCACGCAGGCCCCTGAACACCACT
GAGGGCCAAGCGACGCTGGAGGTGGCCAGCGACAGTTACCACAAGGTAGCCTCTGACGTC
GCCCTGCTTTGCGGCCTCCGGGCTCAGGTGTACAAGTTCTCCATCTCCTGGTCCCGGATC
TTCCCCATGGGGCACGGGAGCAGCCCCAGCCTCCCAGGCGTTGCCTACTACAACAAGCTG
ATTGACAGGCTACAGGATGCGGGCATCGAGCCCATGGCCACGCTGTTCCACTGGGACCTG
CCTCAGGCCCTGCAGGATCATGGTGGATGGCAGAATGAGAGCGTGGTGGATGCCTTCCTG
GACTATGCGGCCTTCTGCTTCTCCACATTTGGGGACCGTGTGAAGCTGTGGGTGACCTTC
CATGAGCCGTGGGTGATGAGCTACGCAGGCTATGGCACCGGCCAGCACCCTCCCGGCATC
TCTGACCCAGGAGTGGCCTCTTTTAAGGTGGCTCACTTGGTCCTCAAGGCTCATGCCAGA
ACTTGGCACCACTACAACAGCCATCATCGCCCACAGCAGCAGGGGCACGTGGGCATTGTG
CTGAACTCAGACTGGGCAGAACCCCTGTCTCCAGAGAGGCCTGAGGACCTGAGAGCCTCT
GAGCGCTTCTTGCACTTCATGCTGGGCTGGTTTGCACACCCCGTCTTTGTGGATGGAGAC
TACCCAGCCACCCTGAGGACCCAGATCCAACAGATGAACAGACAGTGCTCCCATCCTGTG
GCTCAACTCCCCGAGTTCACAGAGGCAGAGAAGCAGCTCCTGAAAGGCTCTGCTGATTTT
CTGGGTCTGTCGCATTACACCTCCCGCCTCATCAGCAACGCCCCACAAAACACCTGCATC
CCTAGCTATGATACCATTGGAGGCTTCTCCCAACACGTGAACCATGTGTGGCCCCAGACC
TCATCCTCTTGGATTCGTGTGGTGCCCTGGGGGATAAGGAGGCTGTTGCAGTTTGTATCC
CTGGAATACACAAGAGGAAAAGTTCCAATATACCTTGCCGGGAATGGCATGCCCATAGGG
GAAAGTGAAAATCTCTTTGATGATTCCTTAAGAGTAGACTACTTCAATCAATATATCAAT
GAGGTGCTCAAGGCTATCAAGGAAGACTCTGTGGATGTTCGTTCCTACATTGCTCGTTCC
CTCATTGATGGCTTCGAAGGCCCTTCTGGTTACAGCCAGCGGTTTGGCCTGCACCACGTC
AACTTCAGCGACAGCAGCAAGTCAAGGACTCCCAGGAAATCTGCCTACTTTTTCACTAGC
ATCATAGAAAAGAACGGTTTCCTCACCAAGGGGGCAAAAAGACTGCTACCACCTAATACA
GTAAACCTCCCCTCCAAAGTCAGAGCCTTCACTTTTCCATCTGAGGTGCCCTCCAAGGCT
AAAGTCGTTTGGGAAAAGTTCTCCAGCCAACCCAAGTTCGAAAGAGATTTGTTCTACCAC
GGGACGTTTCGGGATGACTTTCTGTGGGGCGTGTCCTCTTCCGCTTATCAGATTGAAGGC
GCGTGGGATGCCGATGGCAAAGGCCCCAGCATCTGGGATAACTTTACCCACACACCAGGG
AGCAATGTGAAAGACAATGCCACTGGAGACATCGCCTGTGACAGCTATCACCAGCTGGAT
GCCGATCTGAATATGCTCCGAGCTTTGAAGGTGAAGGCCTACCGCTTCTCTATCTCCTGG
TCTCGGATTTTCCCAACTGGGAGAAACAGCTCTATCAACAGTCATGGGGTTGATTATTAC
AACAGGCTGATCAATGGCTTGGTGGCAAGCAACATCTTTCCCATGGTGACATTGTTCCAT
TGGGACCTGCCCCAGGCCCTCCAGGATATCGGAGGCTGGGAGAATCCTGCCTTGATTGAC
TTGTTTGACAGCTACGCAGACTTTTGTTTCCAGACCTTTGGTGATAGAGTCAAGTTTTGG
ATGACTTTTAATGAGCCCATGTACCTGGCATGGCTAGGTTATGGCTCAGGGGAATTTCCC
CCAGGGGTGAAGGACCCAGGCTGGGCACCATATAGGATAGCCCACACCGTCATCAAAGCC
CATGCCAGAGTCTATCACACGTACGATGAGAAATACAGGCAGGAGCAGAAGGGGGTCATC
TCGCTGAGCCTCAGTACACACTGGGCAGAGCCCAAGTCACCAGGGGTCCCCAGAGATGTG
GAAGCCGCTGACCGAATGCTGCAGTTCTCCCTGGGCTGGTTTGCTCACCCCATTTTTAGA
AACGGAGACTATCCTGACACCATGAAGTGGAAAGTGGGGAACAGGAGTGAACTGCAGCAC
TTAGCCACCTCCCGCCTGCCAAGCTTCACTGAGGAAGAGAAGAGGTTCATCAGGGCGACG
GCCGACGTCTTCTGCCTCAACACGTACTACTCCAGAATCGTGCAGCACAAAACACCCAGG
CTAAACCCACCCTCCTACGAAGACGACCAGGAGATGGCTGAGGAGGAGGACCCTTCGTGG
CCTTCCACGGCAATGAACAGAGCTGCGCCCTGGGGGACGCGAAGGCTGCTGAACTGGATC
AAGGAAGAGTATGGTGACATCCCCATTTACATCACCGAAAACGGAGTGGGGCTGACCAAT
CCGAACACGGAGGATACTGATAGGATATTTTACCACAAAACCTACATCAATGAGGCTTTG
AAAGCCTACAGGCTCGATGGTATAGACCTTCGAGGGTATGTCGCCTGGTCTCTGATGGAC
AACTTTGAGTGGCTAAATGGCTACACGGTCAAGTTTGGACTGTACCATGTTGATTTCAAC
AACACGAACAGGCCTCGCACAGCAAGAGCCTCCGCCAGGTACTACACAGAGGTCATTACC
AACAACGGCATGCCACTGGCCAGGGAGGATGAGTTTCTGTACGGACGGTTTCCTGAGGGC
TTCATCTGGAGTGCAGCTTCTGCTGCATATCAGATTGAAGGTGCGTGGAGAGCAGATGGC
AAAGGACTCAGCATTTGGGACACGTTTTCTCACACACCACTGAGGGTTGAGAACGATGCC
ATTGGAGACGTGGCCTGTGACAGTTATCACAAGATTGCTGAGGATCTGGTCACCCTGCAG
AACCTGGGTGTGTCCCACTACCGTTTTTCCATCTCCTGGTCTCGCATCCTCCCTGATGGA
ACCACCAGGTACATCAATGAAGCGGGCCTGAACTACTACGTGAGGCTCATCGATACACTG
CTGGCCGCCAGCATCCAGCCCCAGGTGACCATTTACCACTGGGACCTACCACAGACGCTC
CAAGATGTAGGAGGCTGGGAGAATGAGACCATCGTGCAGCGGTTTAAGGAGTATGCAGAT
GTGCTCTTCCAGAGGCTGGGAGACAAGGTGAAGTTTTGGATCACGTTGAATGAGCCCTTT
GTCATTGCTTACCAGGGCTATGGCTACGGAACAGCAGCTCCAGGAGTCTCCAATAGGCCT
GGCACTGCCCCCTACATTGTTGGCCACAATCTAATAAAGGCTCATGCTGAGGCCTGGCAT
CTGTACAACGATGTGTACCGCGCCAGTCAAGGTGGCGTGATTTCCATCACCATCAGCAGT
GACTGGGCTGAACCCAGAGATCCCTCTAACCAGGAGGATGTGGAGGCAGCCAGGAGATAT
GTTCAGTTCATGGGAGGCTGGTTTGCACATCCTATTTTCAAGAATGGAGATTACAATGAG
GTGATGAAGACGCGGATCCGTGACAGGAGCTTGGCTGCAGGCCTCAACAAGTCTCGGCTG
CCAGAATTTACAGAGAGTGAGAAGAGGAGGATCAACGGCACCTATGACTTTTTTGGGTTC
AATCACTACACCACTGTCCTCGCCTACAACCTCAACTATGCCACTGCCATCTCTTCTTTT
GATGCAGACAGAGGAGTTGCTTCCATCGCAGATCGCTCGTGGCCAGACTCTGGCTCCTTC
TGGCTGAAGATGACGCCTTTTGGCTTCAGGAGGATCCTGAACTGGTTAAAGGAGGAATAC
AATGACCCTCCAATTTATGTCACAGAGAATGGAGTGTCCCAGCGGGAAGAAACAGACCTC
AATGACACTGCAAGGATCTACTACCTTCGGACTTACATCAATGAGGCCCTCAAAGCTGTG
CAGGACAAGGTGGACCTTCGAGGATACACAGTTTGGAGTGCGATGGACAATTTTGAGTGG
GCCACAGGCTTTTCAGAGAGATTTGGTCTGCATTTTGTGAACTACAGTGACCCTTCTCTG
CCAAGGATCCCCAAAGCATCAGCGAAGTTCTACGCCTCTGTGGTCCGATGCAATGGCTTC
CCTGACCCCGCTACAGGGCCTCACGCTTGTCTCCACCAGCCAGATGCTGGACCCACCATC
AGCCCCGTGAGACAGGAGGAGGTGCAGTTCCTGGGGCTAATGCTCGGCACCACAGAAGCA
CAGACAGCTTTGTACGTTCTCTTTTCTCTTGTGCTTCTTGGAGTCTGTGGCTTGGCATTT
CTGTCATACAAGTACTGCAAGCGCTCTAAGCAAGGGAAAACACAACGAAGCCAACAGGAA
TTGAGCCCGGTGTCTTCATTCTGA

# Metabolic_Enzyme_14_GenBank_ID_Gene:
X07994

# Metabolic_Enzyme_14_Chromosome_Location:
Not Available

# Metabolic_Enzyme_14_Locus:
Not Available

# Metabolic_Enzyme_14_SNPs:
Not Available

# Metabolic_Enzyme_14_General_References:
2460343; 1902057

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
6124

# Metabolic_Enzyme_15_Name:
Beta-galactosidase precursor

# Metabolic_Enzyme_15_Synonyms:
Lactase; Acid beta- galactosidase

# Metabolic_Enzyme_15_Gene_Name:
GLB1

# Metabolic_Enzyme_15_Protein_Sequence:
>Betagalactosidase precursor
MPGFLVRILLLLLVLLLLGPTRGLRNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRV
PRFYWKDRLL
KMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVI
LRPGPYICAEWEMGGLPAWLL
EKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGG
PVITVQVENEYGSYFACDFDYLRFLQKRFRHH
LGDDVVLFTTDGAHKTFLKCGALQGLY
TTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQP
HSTIKTEAVASSLYDI
LARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFAL
RNIIQ
KFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGF
VLYRT
TLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLD
LLVENMGRVNYGAYIN
DFKGLVSNLTLSSNILTDWTIFPLDTEDAVRSHLGGWGHRDSG
HHDEAWAHNSSNYTLPAFYMGNFSIPS
GIPDLPQDTFIQFPGWTKGQVWINGFNLGRYW
PARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDD
PELCAVTFVDRPVIGSSVTYD
HPSKPVEKRLMPPPPQKNKDSWLDHV

# Metabolic_Enzyme_15_Number_of_Residues:
677

# Metabolic_Enzyme_15_Molecular_Weight:
76092

# Metabolic_Enzyme_15_Theoretical_pI:
6.55

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  galactosidase activity
Function:  beta-galactosidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  protein complex
Component:  unlocalized protein complex
Component:  beta-galactosidase complex

# Metabolic_Enzyme_15_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_15_Specific_Function:
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans

# Metabolic_Enzyme_15_Pathway:
map00052  Galactose metabolism;
 map00511  N-Glycan degradation;
 map00531  Glycosaminoglycan degradation;
 map00561  Glycerolipid metabolism;
 map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_15_Reaction:
Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF01301:Glyco_hydro_35

# Metabolic_Enzyme_15_Signals:
1-23

# Metabolic_Enzyme_15_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 3.2.1.23

# Metabolic_Enzyme_15_GenBank_ID_Protein:
179401

# Metabolic_Enzyme_15_SwissProt_ID:
BGAL_HUMAN (P16278)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
GLB1

# Metabolic_Enzyme_15_Geneatlas_id:
GLB1

# Metabolic_Enzyme_15_hgnc_id:
HGNC:4298

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_15_Gene_Sequence:
>2034 bp

ATGCCGGGGTTCCTGGTTCGCATCCTCCTTCTGCTGCTGGTTCTGCTGCTTCTGGGCCC
TACGCGCGGCT
TGCGCAATGCCACCCAGAGGATGTTTGAAATTGACTATAGCCGGGACT
CCTTCCTCAAGGATGGCCAGCC
ATTTCGCTACATCTCAGGAAGCATTCACTACTCCCGT
GTGCCCCGCTTCTACTGGAAGGACCGGCTGCTG
AAGATGAAGATGGCTGGGCTGAACGC
CATCCAGACGTATGTGCCCTGGAACTTTCATGAGCCCTGGCCAG
GACAGTACCAGTTTT
CTGAGGACCATGATGTGGAATATTTTCTTCGGCTGGCTCATGAGCTGGGACTGCT
GGTT
ATCCTGAGGCCCGGGCCCTACATCTGTGCAGAGTGGGAAATGGGAGGATTACCTGCTTGG
CTGCTA
GAGAAAGAGTCTATTCTTCTCCGCTCCTCCGACCCAGATTACCTGGCAGCTGT
GGACAAGTGGTTGGGAG
TCCTTCTGCCCAAGATGAAGCCTCTCCTCTATCAGAATGGAG
GGCCAGTTATAACAGTGCAGGTTGAAAA
TGAATATGGCAGCTACTTTGCCTGTGATTTT
GACTACCTGCGCTTCCTGCAGAAGCGCTTTCGCCACCAT
CTGGGGGATGATGTGGTTCT
GTTTACCACTGATGGAGCACATAAAACATTCCTGAAATGTGGGGCCCTGC
AGGGCCTCT
ACACCACGGTGGACTTTGGAACAGGCAGCAACATCACAGATGCTTTCCTAAGCCAGAGGA
A
GTGTGAGCCCAAAGGACCCTTGATCAATTCTGAATTCTATACTGGCTGGCTAGATCAC
TGGGGCCAACCT
CACTCCACAATCAAGACCGAAGCAGTGGCTTCCTCCCTCTATGATAT
ACTTGCCCGTGGGGCGAGTGTGA
ACTTGTACATGTTTATAGGTGGGACCAATTTTGCCT
ATTGGAATGGGGCCAACTCACCCTATGCAGCACA
GCCCACCAGCTACGACTATGATGCC
CCACTGAGTGAGGCTGGGGACCTCACTGAGAAGTATTTTGCTCTG
CGAAACATCATCCA
GAAGTTTGAAAAAGTACCAGAAGGTCCTATCCCTCCATCTACACCAAAGTTTGCAT
ATG
GAAAGGTCACTTTGGAAAAGTTAAAGACAGTGGGAGCAGCTCTGGACATTCTGTGTCCCT
CTGGGCC
CATCAAAAGCCTTTATCCCTTGACATTTATCCAGGTGAAACAGCATTATGGG
TTTGTGCTGTACCGGACA
ACACTTCCTCAAGATTGCAGCAACCCAGCACCTCTCTCTTC
ACCCCTCAATGGAGTCCACGATCGAGCAT
ATGTTGCTGTGGATGGGATCCCCCAGGGAG
TCCTTGAGCGAAACAATGTGATCACTCTGAACATAACAGG
GAAAGCTGGAGCCACTCTG
GACCTTCTGGTAGAGAACATGGGACGTGTGAACTATGGTGCATATATCAAC
GATTTTAA
GGGTTTGGTTTCTAACCTGACTCTCAGTTCCAATATCCTCACGGACTGGACGATCTTTCC
AC
TGGACACTGAGGATGCAGTGCGCAGCCACCTGGGGGGCTGGGGACACCGTGACAGTG
GCCACCATGATGA
AGCCTGGGCCCACAACTCATCCAACTACACGCTCCCGGCCTTTTAT
ATGGGGAACTTCTCCATTCCCAGT
GGGATCCCAGACTTGCCCCAGGACACCTTTATCCA
GTTTCCTGGATGGACCAAGGGCCAGGTCTGGATTA
ATGGCTTTAACCTTGGCCGCTATT
GGCCAGCCCGGGGCCCTCAGTTGACCTTGTTTGTGCCCCAGCACAT
CCTGATGACCTCG
GCCCCAAACACCATCACCGTGCTGGAACTGGAGTGGGCACCCTGCAGCAGTGATGAT
CC
AGAACTATGTGCTGTGACGTTCGTGGACAGGCCAGTTATTGGCTCATCTGTGACCTACGA
TCATCCCT
CCAAACCTGTTGAAAAAAGACTCATGCCCCCACCCCCGCAAAAAAACAAAG
ATTCATGGCTGGACCATGT
ATGA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
M27507

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_15_Locus:
3p21.33

# Metabolic_Enzyme_15_SNPs:
rs4302331; rs35289681; rs4645101; rs6805519; rs7614585; rs3924695; rs4679075; rs9869052; rs4350874; rs6550204; rs4479543; rs9827863; rs9868526; rs4277638; rs6550200; rs4679074; rs6780220; rs7613051; rs6781225; rs6777787; rs4438612; rs6550203; rs9828592; rs4423716; rs7616912; rs7629880; rs4679082; rs4320035; rs9311003; rs9310999; rs6550202; rs6802807; rs6766207; rs3924696; rs6805766; rs4678613; rs6781531; rs6766191; rs4074708; rs6550191; rs13078132; rs9311001; rs4528891; rs4402881; rs4234266; rs7637435; rs6550205; rs4130167; rs9863198; rs9875798; rs12632196; rs6782510; rs9849898; rs1133253; rs4234262; rs9833676; rs11708012; rs9865921; rs9311002; rs4678868; rs4678660; rs12635761; rs9826234; rs11715310; rs6762132; rs7646283; rs9310998; rs10154834; rs11707667; rs13093517; rs4678657; rs11129544; rs4270461; rs9861960; rs11714207; rs12633904; rs13314478; rs7643224; rs12495572; rs4328758; rs13093698; rs4679076; rs9883177; rs13080709; rs4274702; rs6550199; rs11129542; rs9810375; rs11717007; rs11712996; rs4343578; rs6773715; rs9858362; rs9815409; rs13078515; rs13096312; rs4679077; rs6785135; rs9861316; rs13324134; rs4257495; rs11718295; rs9852589; rs4234267; rs9824270; rs9816051; rs9860199; rs9866187; rs7626612; rs9831065; rs9868815; rs9852081; rs7610177; rs4311175; rs9865232; rs9817993; rs9882717; rs9824218; rs7616228; rs6770187; rs9819337; rs4493381; rs6768988; rs7618005; rs4575834; rs12054351; rs35000357; rs6776757; rs13081593; rs4263242; rs9827128; rs6770614; rs13078446; rs9883376; rs4998983; rs11706136; rs9830701; rs4678652; rs7628722; rs4269037; rs6783481; rs7610270; rs4491851; rs13094148; rs6769803; rs9845011; rs12491500; rs6805872; rs9851902; rs9860184; rs9754700; rs6770682; rs9838286; rs9840748; rs9810955; rs9829197; rs11129543; rs12490111; rs4679097; rs9872578; rs4558698; rs9814670; rs9841000; rs34173901; rs4456812; rs9858291; rs11924625; rs4383462; rs4630893; rs6782297; rs4583587; rs4678644; rs6786613; rs7610916; rs7650543; rs11720449; rs4547648; rs9865113; rs11707205; rs7645956; rs34103134; rs4428129; rs11927929; rs4371463; rs13079353; rs4234264; rs11713054; rs6769787; rs9849213; rs9851459; rs12633200; rs9817393; rs6782318; rs9880004; rs9863331; rs12167; rs7643313; rs4678523; rs4678524; rs1803198; rs13073546; rs1803199; rs34421970; rs1803200; rs34204221; rs6776436; rs35360222; rs35516563; rs35949170; rs35217324; rs34064757; rs9681623; rs35066652; rs9879174; rs28457681; rs35366996; rs12636380; rs35546490; rs4411834; rs34170794; rs34840292; rs11706680; rs35079906; rs35567563; rs35096418; rs34190372; rs34267899; rs9835090; rs34542942; rs28564715; rs34783720; rs35299531; rs28752078; rs35609083; rs4404396; rs10596366; rs36061528; rs35625458; rs6550190; rs4678642; rs35791447; rs35543972; rs10702620; rs7612742; rs11387959; rs9875140; rs9858992; rs28538948; rs4472006; rs34081225; rs35480293; rs11443960; rs34301631; rs34629244; rs9836304; rs4678941; rs9825789; rs11927839; rs35111870; rs35849739; rs34459243; rs6767833; rs7431645; rs10683710; rs28488329; rs9825335; rs35781117; rs9872225; rs34491679; rs13077125; rs9858364; rs11342344; rs35553546; rs35894066; rs10559091; rs35313892; rs6800001; rs13079744; rs13062239; rs10662168; rs6772595; rs13059918; rs34558646; rs28615536; rs11303788; rs10679653; rs36181668; rs35688004; rs11414853; rs7610165; rs35269925; rs11348689; rs34388197; rs11459888; rs9852362; rs4678643; rs4130168; rs11328798; rs7621255; rs11276167; rs11915291; rs28727973; rs13092698; rs34500490; rs36036446; rs7610931; rs35201739; rs6785862; rs11428956; rs11385614; rs4234263; rs7619312; rs11717735; rs34139339; rs34827860; rs6776437; rs6770268; rs12054117; rs34097913; rs11416783; rs35555652; rs36140454; rs9848784; rs10613912; rs35419837; rs35291321; rs4613407; rs34772446; rs35570272; rs7650438; rs6792048; rs11289119; rs11707202; rs7646643; rs35879433; rs35844867; rs28420683; rs28617702; rs34103242; rs35684962; rs34958264; rs9845695; rs34986791; rs35533674; rs34652262; rs7628609; rs35507451; rs35777526; rs35835691; rs4298001; rs35847345; rs35580094; rs28372666; rs34648323; rs13098058; rs9865342; rs34547154; rs35399363; rs35548830; rs9811260; rs34925031; rs4130166; rs10661628; rs9849872; rs35026670; rs13072499; rs34482863; rs4447709; rs4508727; rs12487241; rs9831194; rs13082782; rs10529787; rs13314904; rs4234234; rs9873651; rs5847772; rs11423270; rs9850839; rs10528005; rs35809982; rs9838124; rs4678849; rs11711396; rs11715480; rs11718846; rs11914868; rs12635828; rs4075736; rs4578976; rs4678677; rs4678774; rs6769735; rs6793913; rs7612234; rs7614776; rs9860567

# Metabolic_Enzyme_15_General_References:
2511208; 2111707; 3143362; 10841810; 10571006; 1928092; 1909089; 1907800; 1487238; 8213816; 8198123; 7586649; 9203065; 12393180; 10338095; 10839995; 10737981; 11511921

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
6064

# Metabolic_Enzyme_16_Name:
Alcohol dehydrogenase 1A

# Metabolic_Enzyme_16_Synonyms:
Alcohol dehydrogenase alpha subunit

# Metabolic_Enzyme_16_Gene_Name:
ADH1A

# Metabolic_Enzyme_16_Protein_Sequence:
>Alcohol dehydrogenase 1
AMSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAVGICGTDDHVVSGTMV
TPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLAIPQCGKCRICKNPESNYCLKNDVSN
PQGTLQDGTSRFTCRRKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFST
GYGSAVNVAKVTPGSTCAVFGLGGVGLSAIMGCKAAGAARIIAVDINKDKFAKAKELGAT
ECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDS
QNLSMNPMLLLTGRTWKGAILGGFKSKECVPKLVADFMAKKFSLDALITHVLPFEKINEG
FDLLHSGKSIRTILMF

# Metabolic_Enzyme_16_Number_of_Residues:
375

# Metabolic_Enzyme_16_Molecular_Weight:
39859

# Metabolic_Enzyme_16_Theoretical_pI:
8.02

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_16_Specific_Function:
An alcohol + NAD(+) = an aldehyde or ketone + NADH

# Metabolic_Enzyme_16_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_16_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_16_Signals:
None

# Metabolic_Enzyme_16_Transmembrane_Regions:
None

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_16_GenBank_ID_Protein:
178092

# Metabolic_Enzyme_16_SwissProt_ID:
ADH1A_HUMAN (P07327)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
ADH1A

# Metabolic_Enzyme_16_Geneatlas_id:
ADH1A

# Metabolic_Enzyme_16_hgnc_id:
HGNC:249

# Metabolic_Enzyme_16_PDB_ID:
1HSO

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_16_Gene_Sequence:
>1128 bp
ATGAGCACAGCAGGAAAAGTAATCAAATGCAAAGCAGCTGTGCTATGGGAGTTAAAGAAA
CCCTTTTCCATTGAGGAGGTGGAGGTTGCACCTCCTAAGGCCCATGAAGTTCGTATTAAG
ATGGTGGCTGTAGGAATCTGTGGCACAGATGACCACGTGGTTAGTGGTACCATGGTGACC
CCACTTCCTGTGATTTTAGGCCATGAGGCAGCCGGCATCGTGGAGAGTGTTGGAGAAGGG
GTGACTACAGTCAAACCAGGTGATAAAGTCATCCCACTCGCTATTCCTCAGTGTGGAAAA
TGCAGAATTTGTAAAAACCCGGAGAGCAACTACTGCTTGAAAAACGATGTAAGCAATCCT
CAGGGGACCCTGCAGGATGGCACCAGCAGGTTCACCTGCAGGAGGAAGCCCATCCACCAC
TTCCTTGGCATCAGCACCTTCTCACAGTACACAGTGGTGGATGAAAATGCAGTAGCCAAA
ATTGATGCAGCCTCGCCTCTAGAGAAAGTCTGTCTCATTGGCTGTGGATTTTCAACTGGT
TATGGGTCTGCAGTCAATGTTGCCAAGGTCACCCCAGGCTCTACCTGTGCTGTGTTTGGC
CTGGGAGGGGTCGGCCTATCTGCTATTATGGGCTGTAAAGCAGCTGGGGCAGCCAGAATC
ATTGCGGTGGACATCAACAAGGACAAATTTGCAAAGGCCAAAGAGTTGGGGGCCACTGAA
TGCATCAACCCTCAAGACTACAAGAAACCCATCCAGGAGGTGCTAAAGGAAATGACTGAT
GGAGGTGTGGATTTTTCATTTGAAGTCATCGGTCGGCTTGACACCATGATGGCTTCCCTG
TTATGTTGTCATGAGGCATGTGGCACAAGTGTCATCGTAGGGGTACCTCCTGATTCCCAA
AACCTCTCAATGAACCCTATGCTGCTACTGACTGGACGTACCTGGAAGGGAGCTATTCTT
GGTGGCTTTAAAAGTAAAGAATGTGTCCCAAAACTTGTGGCTGATTTTATGGCTAAGAAG
TTTTCATTGGATGCATTAATAACCCATGTTTTACCTTTTGAAAAAATAAATGAAGGATTT
GACCTGCTTCACTCTGGGAAAAGTATCCGTACCATTCTGATGTTTTGA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
M12271

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_16_Locus:
4q21-q23

# Metabolic_Enzyme_16_SNPs:
rs6828526; rs2866151; rs1229970; rs12504321; rs28364312; rs6835771; rs3805325; rs1229969; rs931635; rs975833; rs1229977; rs3805324; rs13120422; rs2276332; rs3819197; rs1229967; rs4147532; rs28364333; rs1229968; rs28364323; rs33991678; rs28364307; rs28364328; rs1229976; rs28364304; rs28364324; rs28364334; rs28364322; rs28364338; rs28364294; rs28364311; rs28364305; rs28364298; rs28364332; rs28364335; rs28364319; rs28364321; rs28364292; rs28364313; rs28364329; rs28364336; rs28364296; rs4147531; rs12512110; rs1229966; rs13120304; rs7684674; rs17584149; rs28364286; rs6835371; rs28364283; rs28364342; rs13134764; rs28364341; rs28364340; rs28364325; rs28364337; rs28364315; rs10690902; rs28364293; rs34073783; rs4147533; rs28364297; rs28364301; rs28364306; rs28364314; rs35568460; rs28521649; rs28745868; rs28364330; rs13126850; rs28364300; rs28364317; rs28364339; rs28364327; rs12645219; rs13116877; rs1229971; rs28364309; rs28364331; rs2051429; rs12508502; rs12504365; rs28364295; rs28364316; rs35613639; rs34235527; rs28364326; rs12512053; rs28364299; rs28364308; rs28364303; rs28364318; rs35573104; rs33992258; rs5860574; rs28364320; rs34362837; rs6854980; rs28364289; rs28364285; rs35984131; rs34231176; rs5860573; rs35354633; rs11461839; rs28364287; rs28364282; rs28364290; rs2173198; rs28364288; rs28364343; rs28364284; rs28364291; rs1230024; rs12504387; rs13103321; rs13117371; rs13123099; rs13145277; rs17028765; rs17028770; rs2051427; rs6811453; rs6812015; rs6837311; rs904092

# Metabolic_Enzyme_16_General_References:
3013304; 2935875; 2920825; 2347582

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
6116

# Metabolic_Enzyme_17_Name:
Glycerol kinase, testis specific 2

# Metabolic_Enzyme_17_Synonyms:
ATP:glycerol 3- phosphotransferase; Glycerokinase; GK

# Metabolic_Enzyme_17_Gene_Name:
GK2

# Metabolic_Enzyme_17_Protein_Sequence:
>Glycerol kinase, testis specific 2
MAAPKTAAVGPLVGAVVQGTNSTRFLVFNSKTAELLSHHKVELTQEFPKEGWVEQDPKEI
LQSVYECIARTCEKLDELNIDISNIKAVGVSNQRETTVIWDKLTGEPLYNAVVWLDLRTQ
TTVEDLSKKIPGNSNFVKSKTGLPLSTYFSAVKLRWMLDNVRNVQKAVEEGRALFGTIDS
WLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKELCDFFEIPMDLLPNVFSSSEIY
GLIKTGALEGVPISGCLGDQCAALVGQMCFQEGQAKNTYGTGCFLLCNTGRKCVFSEHGL
LTTVAYKLGREKPAYYALEGSVAIAGAVIRWLRDNLGIIETSGDIERLAKEVGTSYGCYF
VPAFSGLYAPYWEPSARGILCGLTQFTNKCHIAFAALEAVCFQTREILEAMNRDCGIPLR
HLQVDGGMTNNKVLMQLQADILHIPVIKPFMPETTALGAAMAAGAAEGVSVWSLEPQALS
VLRMERFEPQIQATESEIRYATWKKAVMKSMGWVTSQSPEGGDPSIFCSLPLGFFIVSSM
VMLIGARYISGVP

# Metabolic_Enzyme_17_Number_of_Residues:
553

# Metabolic_Enzyme_17_Molecular_Weight:
60610

# Metabolic_Enzyme_17_Theoretical_pI:
5.53

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  glycerol kinase activity
 ||
>>>
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  polyol metabolism
Process:  glycerol metabolism
Process:  glycerol-3-phosphate metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_17_Specific_Function:
Key enzyme in the regulation of glycerol uptake and metabolism

# Metabolic_Enzyme_17_Pathway:
map00561  Glycerolipid metabolism

# Metabolic_Enzyme_17_Reaction:
ATP + glycerol = ADP + sn-glycerol 3-phosphate

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF02782:FGGY_C;
PF00370:FGGY_N

# Metabolic_Enzyme_17_Signals:
None

# Metabolic_Enzyme_17_Transmembrane_Regions:
None

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 2.7.1.30

# Metabolic_Enzyme_17_GenBank_ID_Protein:
516124

# Metabolic_Enzyme_17_SwissProt_ID:
GLPK2_HUMAN (Q14410)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
GK2

# Metabolic_Enzyme_17_Geneatlas_id:
GK2

# Metabolic_Enzyme_17_hgnc_id:
HGNC:4291

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; peripheral membrane protein; cytoplasmic side. Cytoplasm (By similarity). Note=In sperm the majority of the enzyme is bound to mitochondria (By similarity)

# Metabolic_Enzyme_17_Gene_Sequence:
>1662 bp
ATGGCAGCCCCAAAGACAGCAGCTGTGGGGCCGTTGGTGGGAGCGGTGGTCCAGGGCACC
AACTCCACTCGCTTTCTGGTTTTCAATTCAAAAACAGCGGAACTACTTAGTCATCACAAA
GTGGAATTAACACAAGAGTTTCCAAAAGAAGGATGGGTGGAACAAGACCCTAAAGAAATT
CTTCAGTCTGTCTACGAGTGTATAGCGAGAACGTGTGAGAAACTTGACGAACTGAATATT
GATATATCCAACATAAAAGCTGTTGGTGTCAGCAATCAGAGGGAAACCACTGTAATCTGG
GACAAGTTAACAGGAGAGCCTCTCTACAATGCTGTGGTGTGGCTTGATCTAAGAACCCAG
ACTACTGTTGAGGATCTTAGTAAAAAAATTCCAGGAAATAGTAACTTCGTCAAGTCTAAG
ACAGGCCTTCCACTCAGCACTTACTTCAGTGCAGTAAAACTTCGTTGGATGCTTGACAAT
GTGAGAAACGTCCAAAAGGCTGTTGAAGAAGGTAGAGCTCTTTTTGGTACCATTGATTCA
TGGCTTATCTGGAGTTTGACAGGAGGAGTTAATGGAGGCGTGCATTGTACAGATGTAACA
AATGCAAGTAGGACAATGCTTTTTAATATCCATTCTTTGGAATGGGATAAAGAGCTCTGT
GACTTTTTTGAAATTCCAATGGACCTTCTTCCAAATGTCTTCAGTTCTTCTGAGATCTAT
GGCCTAATTAAAACTGGAGCCCTGGAAGGTGTGCCAATATCTGGGTGTTTGGGGGACCAA
TGTGCTGCATTAGTAGGACAAATGTGCTTCCAGGAGGGACAAGCCAAAAACACCTATGGA
ACAGGTTGCTTCTTACTGTGTAATACGGGTCGTAAATGTGTGTTTTCTGAACATGGCCTT
TTGACCACAGTAGCTTACAAACTAGGCAGAGAGAAGCCAGCATATTATGCACTGGAAGGT
TCTGTTGCTATAGCAGGTGCTGTTATTCGTTGGCTAAGAGACAATCTTGGAATTATAGAG
ACCTCAGGAGACATTGAAAGACTTGCTAAAGAAGTAGGAACTTCTTATGGCTGTTACTTT
GTCCCAGCCTTTTCAGGGTTATATGCACCTTATTGGGAGCCCAGTGCAAGAGGGATACTC
TGTGGCCTCACTCAGTTTACCAATAAATGTCATATTGCTTTTGCTGCATTAGAAGCTGTT
TGTTTCCAAACCCGAGAGATTTTGGAAGCCATGAACCGAGACTGTGGAATTCCACTTCGT
CATTTGCAGGTAGATGGAGGAATGACCAACAACAAAGTTCTTATGCAGCTACAAGCAGAT
ATTCTTCATATTCCAGTAATAAAACCCTTTATGCCTGAAACAACTGCACTAGGAGCTGCC
ATGGCAGCAGGGGCTGCAGAGGGAGTAAGCGTTTGGAGCCTTGAACCCCAGGCTTTGTCA
GTTCTCAGGATGGAACGATTTGAACCACAGATCCAGGCCACAGAAAGTGAAATTCGTTAT
GCCACATGGAAGAAAGCCGTAATGAAGTCAATGGGTTGGGTTACCAGTCAGTCTCCTGAA
GGTGGTGATCCTTCTATCTTCTGTAGTCTGCCTTTGGGATTTTTTATAGTGAGTAGCATG
GTAATGCTAATTGGAGCAAGATATATCTCGGGTGTGCCATAA

# Metabolic_Enzyme_17_GenBank_ID_Gene:
X78712

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_17_Locus:
4q13

# Metabolic_Enzyme_17_SNPs:
rs6837906; rs34557444; rs1922285; rs10003904; rs4975086; rs17443219; rs10222878; rs7673905; rs1052314; rs11747; rs34499878; rs1238687; rs28459916; rs12499035; rs10222755; rs10049840; rs11930550; rs13113953; rs17003749; rs17003752; rs1882509; rs34310456; rs4627893; rs6837049

# Metabolic_Enzyme_17_General_References:
7987308

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
6065

# Metabolic_Enzyme_18_Name:
Alcohol dehydrogenase 6

# Metabolic_Enzyme_18_Synonyms:
Not Available

# Metabolic_Enzyme_18_Gene_Name:
ADH6

# Metabolic_Enzyme_18_Protein_Sequence:
>Alcohol dehydrogenase 6
MSTTGQVIRCKAAILWKPGAPFSIEEVEVAPPKAKEVRIKVVATGLCGTEMKVLGSKHLD
LLYPTILGHE
GAGIVESIGEGVSTVKPGDKVITLFLPQCGECTSCLNSEGNFCIQFKQS
KTQLMSDGTSRFTCKGKSIYH
FGNTSTFCEYTVIKEISVAKIDAVAPLEKVCLISCGFS
TGFGAAINTAKVTPGSTCAVFGLGGVGLSVVM
GCKAAGAARIIGVDVNKEKFKKAQELG
ATECLNPQDLKKPIQEVLFDMTDAGIDFCFEAIGNLDVLAAAL
ASCNESYGVCVVVGVL
PASVQLKISGQLFFSGRSLKGSVFGGWKSRQHIPKLVADYMAEKLNLDPLITHT
LNLDK
INEAVELMKTGKW

# Metabolic_Enzyme_18_Number_of_Residues:
368

# Metabolic_Enzyme_18_Molecular_Weight:
39073

# Metabolic_Enzyme_18_Theoretical_pI:
7.86

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_18_Specific_Function:
An alcohol + NAD(+) = an aldehyde or ketone + NADH

# Metabolic_Enzyme_18_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_18_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_18_Signals:
None

# Metabolic_Enzyme_18_Transmembrane_Regions:
None

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 1.1.1.1

# Metabolic_Enzyme_18_GenBank_ID_Protein:
178146

# Metabolic_Enzyme_18_SwissProt_ID:
ADH6_HUMAN (P28332)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
ADH6

# Metabolic_Enzyme_18_Geneatlas_id:
ADH6

# Metabolic_Enzyme_18_hgnc_id:
HGNC:255

# Metabolic_Enzyme_18_PDB_ID:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_18_Gene_Sequence:
>1107 bp

ATGAGTACTACAGGCCAAGTCATCAGATGCAAAGCAGCCATACTCTGGAAGCCTGGTGC
ACCATTTTCTA
TTGAAGAGGTAGAAGTGGCCCCACCAAAGGCAAAGGAGGTTCGCATAA
AGGTTGTGGCCACCGGACTGTG
TGGTACAGAGATGAAAGTGTTGGGGAGTAAACACTTG
GACCTCTTGTATCCCACCATCTTGGGCCATGAA
GGGGCTGGAATCGTTGAGAGTATTGG
AGAAGGAGTAAGCACAGTGAAACCAGGTGACAAAGTTATCACAC
TCTTTCTGCCACAGT
GTGGAGAATGTACCTCTTGCCTGAATTCTGAGGGCAATTTTTGTATACAATTCAA
ACAG
TCAAAAACCCAACTGATGTCTGATGGTACCAGCAGGTTTACCTGCAAGGGAAAATCAATA
TATCAC
TTTGGTAATACCAGCACCTTCTGTGAATACACAGTGATAAAGGAAATCTCAGT
TGCCAAGATTGATGCAG
TCGCTCCTCTAGAGAAAGTATGCCTAATTAGCTGTGGCTTTT
CCACTGGGTTTGGTGCTGCAATCAATAC
TGCCAAGGTGACTCCAGGTTCTACCTGTGCT
GTGTTTGGCCTGGGAGGAGTCGGCTTGTCTGTTGTCATG
GGTTGTAAAGCAGCAGGAGC
AGCCAGGATCATTGGAGTGGATGTCAACAAGGAGAAATTTAAGAAGGCAC
AGGAATTGG
GTGCGACTGAGTGCCTCAACCCTCAGGACTTAAAGAAACCCATTCAAGAAGTTTTATTTG
A
TATGACAGATGCTGGTATAGACTTCTGCTTTGAGGCCATTGGAAATCTGGACGTTCTG
GCAGCTGCCCTC
GCCTCCTGCAATGAGAGCTATGGGGTCTGTGTGGTTGTTGGGGTGTT
GCCTGCCAGTGTTCAACTCAAAA
TCAGTGGCCAGTTGTTCTTCTCAGGACGTTCTTTGA
AGGGTTCTGTTTTTGGAGGCTGGAAGAGCAGACA
GCACATCCCTAAACTGGTTGCTGAT
TATATGGCAGAGAAGTTGAATCTAGATCCACTAATTACTCATACT
CTGAATCTTGATAA
AATCAATGAAGCAGTTGAATTAATGAAAACTGGAAAATGGTAA

# Metabolic_Enzyme_18_GenBank_ID_Gene:
M84402

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_18_Locus:
4q23

# Metabolic_Enzyme_18_SNPs:
rs34582580; rs3857224; rs4147547; rs2156733; rs2187483; rs4147545; rs4699733; rs6833176; rs9307238; rs4147544; rs17219626; rs7692358; rs17219837; rs9995799; rs7661441; rs17028743; rs10030920; rs6820368; rs1893882; rs17028735; rs28891986; rs28720148; rs28720143; rs28720157; rs28720134; rs28720150; rs28720139; rs28720155; rs28891982; rs17028732; rs4699734; rs5860571; rs28891984; rs28720159; rs28720146; rs28720147; rs28891987; rs28720140; rs28720149; rs28891983; rs17028740; rs28720151; rs28891985; rs1893883; rs10008281; rs13104485; rs10002894; rs2866041; rs12507078; rs28720166; rs28720167; rs28720128; rs28720164; rs28720130; rs28720129; rs28720152; rs4699735; rs28720153; rs4147546; rs6843298; rs28720162; rs1893881; rs28720160; rs33918268; rs28720145; rs11097661; rs28720154; rs28720156; rs5860570; rs4147548; rs17028745; rs28720141; rs34347755; rs28720161; rs34008565; rs10026121; rs34584669; rs28720135; rs34587044; rs4283664; rs3049463; rs36016490; rs10025760; rs28720144; rs5860569; rs28720158; rs28720133; rs11097660; rs35632288; rs34273750; rs28720142; rs35482105; rs34686169; rs35230679; rs11305316; rs35171550; rs28720138; rs28720136; rs1130919; rs28720132; rs1130917; rs34932624; rs1130918; rs28720165; rs34713251; rs28720131; rs28720163; rs35371403; rs34274880; rs1130921; rs11733695; rs12510722; rs2000864; rs2051428; rs6532807; rs6814114; rs6828364; rs6830685

# Metabolic_Enzyme_18_General_References:
1881901

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5549

# Metabolic_Enzyme_19_Name:
Monoglyceride lipase

# Metabolic_Enzyme_19_Synonyms:
MGL; HU-K5; Lysophospholipase homolog; Lysophospholipase-like

# Metabolic_Enzyme_19_Gene_Name:
MGLL

# Metabolic_Enzyme_19_Protein_Sequence:
>Monoglyceride lipase
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP

# Metabolic_Enzyme_19_Number_of_Residues:
303

# Metabolic_Enzyme_19_Molecular_Weight:
33262

# Metabolic_Enzyme_19_Theoretical_pI:
7.00

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  aromatic compound metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_19_Specific_Function:
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes 2-arachidonoylglycerol, a putative endocannabinoid

# Metabolic_Enzyme_19_Pathway:
map00561  Glycerolipid metabolism

# Metabolic_Enzyme_19_Reaction:
Hydrolyses glycerol monoesters of long-chain fatty acids

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF00561:Abhydrolase_1

# Metabolic_Enzyme_19_Signals:
None

# Metabolic_Enzyme_19_Transmembrane_Regions:
None

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 3.1.1.23

# Metabolic_Enzyme_19_GenBank_ID_Protein:
1763011

# Metabolic_Enzyme_19_SwissProt_ID:
MGLL_HUMAN (Q99685)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
MGLL

# Metabolic_Enzyme_19_Geneatlas_id:
MGLL

# Metabolic_Enzyme_19_hgnc_id:
HGNC:17038

# Metabolic_Enzyme_19_PDB_ID:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_19_Gene_Sequence:
>942 bp
ATGGAAACAGGACCTGAAGACCCTTCCAGCATGCCAGAGGAAAGTTCCCCCAGGCGGACC
CCGCAGAGCATTCCCTACCAGGACCTCCCTCACCTGGTCAATGCAGACGGACAGTACCTC
TTCTGCAGGTACTGGAAACCCACAGGCACACCCAAGGCCCTCATCTTTGTGTCCCATGGA
GCCGGAGAGCACAGTGGCCGCTATGAAGAGCTGGCTCGGATGCTGATGGGGCTGGACCTG
CTGGTGTTCGCCCACGACCATGTTGGCCACGGACAGAGCGAAGGGGAGAGGATGGTAGTG
TCTGACTTCCACGTTTTCGTCAGGGATGTGTTGCAGCATGTGGATTCCATGCAGAAAGAC
TACCCTGGGCTTCCTGTCTTCCTTCTGGGCCACTCCATGGGAGGCGCCATCGCCATCCTC
ACGGCCGCAGAGAGGCCGGGCCACTTCGCCGGCATGGTACTCATTTCGCCTCTGGTTCTT
GCCAATCCTGAATCTGCAACAACTTTCAAGGTCCTTGCTGCGAAAGTGCTCAACCTTGTG
CTGCCAAACTTGTCCCTCGGGCCCATCGACTCCAGCGTGCTCTCTCGGAATAAGACAGAG
GTCGACATTTATAACTCAGACCCCCTGATCTGCCGGGCAGGGCTGAAGGTGTGCTTCGGC
ATCCAACTGCTGAATGCCGTCTCACGGGTGGAGCGCGCCCTCCCCAAGCTGACTGTGCCC
TTCCTGCTGCTCCAGGGCTCTGCCGATCGCCTATGTGACAGCAAAGGGGCCTACCTGCTC
ATGGAGTTAGCCAAGAGCCAGGACAAGACTCTCAAGATTTATGAAGGTGCCTACCATGTT
CTCCACAAGGAGCTTCCTGAAGTCACCAACTCCGTCTTCCATGAAATAAACATGTGGGTC
TCTCAAAGGACAGCCACGGCAGGAACTGCGTCCCCACCCTGA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
U67963

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_19_Locus:
3q21.3

# Metabolic_Enzyme_19_SNPs:
rs4881; rs9383; rs7578; rs782444; rs814130; rs3817477; rs814131; rs6439081; rs599287; rs627498; rs534018; rs605188; rs782441; rs803325; rs1437553; rs487369; rs2078637; rs567384; rs1721124; rs479504; rs782437; rs2630210; rs782449; rs541925; rs7652988; rs7653663; rs6439083; rs6772802; rs9759081; rs7648829; rs782440; rs477554; rs7651814; rs526862; rs11915484; rs782080; rs541042; rs600884; rs555183; rs6439082; rs11922836; rs10934819; rs482225; rs11715363; rs9869280; rs13076593; rs2276744; rs1474333; rs1474332; rs512726; rs7637101; rs684358; rs549662; rs7630666; rs484061; rs782436; rs9868912; rs597956; rs1466571; rs893294; rs9846048; rs608318; rs9289316; rs9882914; rs664910; rs587779; rs11925300; rs500104; rs9877819; rs629031; rs6801867; rs547801; rs7648815; rs3773146; rs664095; rs874546; rs13066225; rs16835913; rs664954; rs11917190; rs7615518; rs586919; rs11711929; rs3773159; rs573568; rs556125; rs7621379; rs541855; rs782443; rs3773160; rs782438; rs9825729; rs1437554; rs9757981; rs6787155; rs9289319; rs7635934; rs9877209; rs4974447; rs6778770; rs3773131; rs523925; rs7652615; rs16826716; rs616990; rs9842365; rs9842875; rs13323956; rs585887; rs10934820; rs10512693; rs507961; rs7650669; rs9830196; rs7645411; rs3773142; rs527719; rs6776142; rs17282181; rs16825943; rs11707342; rs7622033; rs12485988; rs621353; rs7634643; rs594323; rs1046821; rs1010174; rs11711251; rs16827188; rs3773154; rs529534; rs782082; rs812156; rs11713989; rs4974448; rs11924145; rs7637817; rs11924045; rs9811688; rs9289321; rs543797; rs3773155; rs586400; rs3773161; rs782295; rs3773137; rs2164754; rs17203666; rs1071912; rs4974449; rs2276745; rs7630461; rs522388; rs9289317; rs693742; rs6439084; rs782433; rs11916152; rs3773147; rs782081; rs6792534; rs6776002; rs9829976; rs11705710; rs6765071; rs2171131; rs3773139; rs9836225; rs561402; rs11709830; rs10512694; rs6791406; rs9860402; rs3732651; rs782434; rs2291372; rs9832418; rs16824401; rs12486711; rs9862130; rs7622377; rs796701; rs483193; rs3773135; rs2276743; rs11719045; rs520154; rs693430; rs4974414; rs7609914; rs6793064; rs6790303; rs7634912; rs688623; rs936839; rs9821704; rs7426633; rs12491505; rs7626899; rs17203659; rs497897; rs16824250; rs584886; rs7644343; rs16823666; rs9852837; rs782450; rs7648644; rs694605; rs7640849; rs471662; rs803059; rs11926105; rs16827117; rs9289320; rs16830397; rs4974415; rs654707; rs13077001; rs782451; rs11706801; rs11717519; rs483421; rs6780384; rs3773138; rs7653846; rs17203673; rs7651126; rs11713938; rs782442; rs9682719; rs604300; rs9823660; rs610795; rs6803366; rs497423; rs3773150; rs11923392; rs16830196; rs3773134; rs13088071; rs12496135; rs11927013; rs16833328; rs6769053; rs782439; rs782452; rs3821582; rs12106944; rs551080; rs6766626; rs13086586; rs7633484; rs16830415; rs11916129; rs3773130; rs481351; rs9856883; rs3773133; rs16825017; rs7631109; rs16835993; rs11719199; rs4974413; rs3821581; rs3773136; rs782445; rs2011138; rs11714763; rs9681081; rs6801421; rs6802526; rs1804711; rs11538700; rs11538698; rs34732369; rs12494477; rs34972627; rs12494528; rs11433015; rs12494533; rs34540434; rs7648804; rs11538699; rs6795640; rs1092128; rs34122388; rs28376787; rs10699515; rs7651012; rs36020109; rs34654963; rs9817523; rs35540950; rs9681464; rs34920427; rs11401380; rs35524851; rs34269884; rs10544371; rs11436982; rs1046820; rs35947819; rs35619448; rs10621235; rs34299476; rs9821239; rs3836353; rs13064150; rs35951289; rs35873899; rs6782885; rs34111506; rs13326079; rs28371855; rs640262; rs13093842; rs34642880; rs35849604; rs3773132; rs7644349; rs28788564; rs10658848; rs35698147; rs41266487; rs9756693; rs9838006; rs28437485; rs34024332; rs35030121; rs809146; rs28595573; rs34790184; rs35948688; rs36093560; rs34659988; rs28496522; rs35586493; rs34587739; rs11269771; rs6797454; rs16835977; rs34968677; rs3836352; rs28527810; rs35826853; rs36060051; rs488015; rs9835873; rs35425959; rs13066844; rs34032579; rs3836350; rs13319109; rs651647; rs9813280; rs5852523; rs13075440; rs35378345; rs3773153; rs35466537; rs35185550; rs11311000; rs7644821; rs28753886; rs13086452; rs6784225; rs4305384; rs5852522; rs34421818; rs35924738; rs9289318; rs34220827; rs10550786; rs10599059; rs7648162; rs10534334; rs13094409; rs35461972; rs10619970; rs34623730; rs9874425; rs35632623; rs35585592; rs34436210; rs11408673; rs6769254; rs10698665; rs35492886; rs35336500; rs34418127; rs35000374; rs6768816; rs3836351; rs4309675; rs35462403; rs4311178; rs34228116; rs35172754; rs3821588; rs35530155; rs34882202; rs10621920; rs35156008; rs478702; rs11923828; rs13093845; rs34884571; rs12632988; rs13084659; rs11428065; rs9881235; rs34240617; rs11294053; rs7646158; rs11342326; rs36232539; rs34709072; rs5852521; rs13071022; rs10563821; rs9867736; rs782435; rs11294169; rs10623100; rs36125403; rs35014000; rs11279104; rs35324977; rs7649495; rs513561; rs10619961; rs9860053; rs1723994; rs35724382; rs35180148; rs34730307; rs11359819; rs11281423; rs9836311; rs9828443; rs13434320; rs41266489; rs28536014; rs34036081; rs35813578; rs34147568; rs10676065; rs6800269; rs1658029; rs34417559; rs7648639; rs35691902; rs35649865; rs16830337; rs35307554; rs34420386; rs9821639; rs607371; rs9858317; rs35233574; rs35444871; rs35044959; rs34265860; rs11395995; rs10529338; rs35931736; rs34275876; rs7355992; rs35942309; rs13316160; rs28504174; rs11706522; rs35275665; rs34169294; rs28532288; rs11293851; rs34517374; rs7651925; rs35163155; rs11715987; rs35253940; rs7649891; rs35492059; rs34439985; rs5852520; rs9815888; rs34543777; rs7428322; rs34558173; rs12492826; rs34959726; rs1053246; rs1053253; rs1053254; rs11716997; rs12488138; rs1683659; rs2336408; rs5013467; rs6774667; rs6774938; rs6784336; rs6808043; rs713378; rs7610520; rs7632589; rs782446; rs782447; rs782448; rs782456; rs9917733

# Metabolic_Enzyme_19_General_References:
9495531; 11470505

# Metabolic_Enzyme_19_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
5562

# Macromolecular_Interacting_Partner_1_Name:
Annexin A3

# Macromolecular_Interacting_Partner_1_Synonyms:
Annexin III; Lipocortin III; Placental anticoagulant protein III; PAP-III; 35-alpha calcimedin; Inositol 1,2-cyclic phosphate 2-phosphohydrolase

# Macromolecular_Interacting_Partner_1_Gene_Name:
ANXA3

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Annexin A3
MASIWVGHRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTERSNAQRQLIVKEY
QAAYGKELKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTR
TSRQMKDISQAYYTVYKKSLGDDISSETSGDFRKALLTLADGRRDESLKVDEHLAKQDAQ
ILYKAGENRWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSIKGELSGHFEDLL
LAIVNCVRNTPAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLY
SAIKSDTSGDYEITLLKICGGDD

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
323

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
36376

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.71

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  phospholipase inhibitor activity
Function:  lipid binding
Function:  phospholipid binding
Function:  calcium-dependent phospholipid binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Inhibitor of phospholipase A2, also possesses anti- coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00191:Annexin

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
307115

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
ANXA3_HUMAN (P12429)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
ANXA3

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
ANXA3

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:541

# Macromolecular_Interacting_Partner_1_PDB_ID:
1AII

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>972 bp
ATGGCATCTATCTGGGTTGGACACCGAGGAACAGTAAGAGATTATCCAGACTTTAGCCCA
TCAGTGGATGCTGAAGCTATTCAGAAAGCAATCAGAGGAATTGGAACTGATGAGAAAATG
CTCATCAGCATTCTGACTGAGAGGTCAAATGCACAGCGGCAGCTGATTGTTAAGGAATAT
CAAGCAGCATATGGAAAGGAGCTGAAAGATGACTTGAAGGGTGATCTCTCTGGCCACTTT
GAGCATCTCATGGTGGCCCTAGTGACTCCACCAGCAGTCTTTGATGCAAAGCAGCTAAAG
AAATCCATGAAGGGCGCGGGAACAAACGAAGATGCCTTGATTGAAATCTTAACTACCAGG
ACAAGCAGGCAAATGAAGGATATCTCTCAAGCCTATTATACAGTATACAAGAAGAGTCTT
GGAGATGACATTAGTTCCGAAACATCTGGTGACTTCCGGAAAGCTCTGTTGACTTTGGCA
GATGGCAGAAGAGATGAAAGTCTGAAAGTGGATGAGCATCTGGCCAAACAAGATGCCCAG
ATTCTCTATAAAGCTGGTGAGAACAGATGGGGCACGGATGAAGACAAATTCACTGAGATC
CTGTGTTTAAGGAGCTTTCCTCAATTAAAACTAACATTTGATGAATACAGAAATATCAGC
CAAAAGGACATTGTGGACAGCATAAAAGGAGAATTATCTGGGCATTTTGAAGACTTACTG
TTGGCCATAGTTAATTGTGTGAGGAACACGCCGGCCTTTTTAGCCGAAAGACTGCATCGA
GCCTTGAAGGGTATTGGAACTGATGAGTTTACTCTGAACCGAATAATGGTGTCCAGATCA
GAAATTGACCTTTTGGACATTCGAACAGAGTTCAAGAAGCATTATGGCTATTCCCTATAT
TCAGCAATTAAATCGGATACTTCTGGAGACTATGAAATCACACTCTTAAAAATCTGTGGT
GGAGATGACTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M20560

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_1_Locus:
4q13-q22

# Macromolecular_Interacting_Partner_1_SNPs:
rs5948; rs5949; rs5951; rs5946; rs17003370; rs5947; rs1042515; rs6533825; rs6829061; rs12498578; rs4612; rs7317; rs6824014; rs1472365; rs867677; rs2867462; rs11725235; rs4466067; rs6533804; rs7661370; rs9307408; rs7679218; rs7670036; rs11098257; rs1496593; rs931602; rs7699779; rs4975071; rs6811289; rs6811432; rs6854010; rs7654600; rs12641838; rs7683399; rs7673877; rs6533779; rs950699; rs1546176; rs3805174; rs6813286; rs7672903; rs1466764; rs10028001; rs4975147; rs6533780; rs5943; rs7683582; rs1390738; rs7694152; rs7686273; rs6851992; rs10029214; rs17003357; rs5944; rs6837662; rs2867461; rs868079; rs6848305; rs1587222; rs10028815; rs7656476; rs1874486; rs10003947; rs5950; rs1546177; rs6833514; rs5945; rs10004883; rs1874487; rs12639656; rs3805175; rs12508999; rs6825653; rs12711028; rs13434871; rs9307407; rs9307406; rs7696371; rs7675646; rs5942; rs1845897; rs1496592; rs1496591; rs1390737; rs7670643; rs7669013; rs9631733; rs17003351; rs7691521; rs17003374; rs9307409; rs10001246; rs10213249; rs17003384; rs1546178; rs17003371; rs1995062; rs13340224; rs1390739; rs11733269; rs6854623; rs6837690; rs11946502; rs11939119; rs1874488; rs1466765; rs11735840; rs7664386; rs17003386; rs1353526; rs1603462; rs7663971; rs17003347; rs7672835; rs17003391; rs7671564; rs1390736; rs17003372; rs867676; rs17003373; rs6844356; rs12644799; rs10452151; rs11736992; rs13126934; rs1546179; rs17003369; rs6533821; rs17003358; rs10023165; rs9993108; rs34279390; rs12509033; rs7660496; rs17003364; rs6833945; rs12642521; rs17003381; rs12647801; rs1496590; rs10010111; rs7661123; rs4975144; rs12640075; rs7672582; rs7666975; rs5941; rs41278059; rs11542067; rs1546180; rs1972024; rs11378485; rs34144661; rs1027451; rs7686951; rs11440235; rs4975146; rs28552884; rs41278061; rs28657834; rs9996290; rs11426511; rs3973925; rs17003344; rs33973348; rs34184370; rs28372309; rs35689949; rs11946509; rs10634730; rs10019438; rs17003389; rs10640523; rs6840577; rs7696370; rs34993575; rs4418000; rs3062785; rs12650752; rs28720813; rs5015973; rs5859637; rs4975072; rs1027450; rs7682725; rs33937505; rs1587221; rs28629444; rs28840375; rs2867460; rs2867459; rs36010355; rs28454015; rs33944058; rs7671376; rs5859636; rs28404993; rs5859639; rs11333070; rs6810513; rs9685634; rs28893007; rs34933657; rs11335718; rs13127051; rs7682502; rs35668860; rs33917697; rs11736963; rs28734842; rs34765788; rs28785284; rs35156545; rs6837672; rs28620217; rs34636970; rs11284873; rs1587223; rs34337674; rs10452152; rs28682404; rs34514573; rs2867458; rs12648686; rs1496589; rs35236048; rs9631719; rs10024660; rs5859638; rs5859641; rs1995063; rs34813704; rs3840270; rs34711932; rs28896883; rs10018015; rs35918068; rs11392121; rs7690308; rs36039411; rs6848162; rs7665553; rs34970825; rs1108907; rs11098274; rs11098275; rs11936220; rs11940309; rs12510411; rs13136035; rs13138005; rs13142813; rs1390740; rs17003337; rs17003396; rs2903577; rs4306980; rs4563523; rs4975143; rs6533826; rs6811335; rs6825328; rs6835998; rs6842686; rs7657082; rs7686681

# Macromolecular_Interacting_Partner_1_General_References:
2968983; 1830024; 8276419; 12665801; 2159184; 2975506; 2138632; 8639653; 10391209

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
7943

# Macromolecular_Interacting_Partner_2_Name:
P2Y purinoceptor 2

# Macromolecular_Interacting_Partner_2_Synonyms:
P2Y2; P2U purinoceptor 1; P2U1; ATP receptor; Purinergic receptor

# Macromolecular_Interacting_Partner_2_Gene_Name:
P2RY2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>P2Y purinoceptor 2
MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVLGLCLNAVALYIFLC
RLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCS
ILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGR
VTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAK
RKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSC
LDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSR
RTESTPAGSENTKDIRL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
377

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
42290

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
9.88

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  nucleotide receptor activity, G-protein coupled
Function:  purinergic nucleotide receptor activity, G-protein coupled
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
33-59
71-93
111-129
153-172
195-220
247-269
288-309

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
984507

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
P2RY2_HUMAN (P41231)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
P2RY2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
P2RY2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:8541

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1134 bp
ATGGCAGCAGACCTGGGCCCCTGGAATGACACCATCAATGGCACCTGGGATGGGGATGAG
CTGGGCTACAGGTGCCGCTTCAACGAGGACTTCAAGTACGTGCTGCTGCCTGTGTCCTAC
GGCGTGGTGTGCGTGCTTGGGCTGTGTCTGAACGCCGTGGCGCTCTACATCTTCTTGTGC
CGCCTCAAGACCTGGAATGCGTCCACCACATATATGTTCCACCTGGCTGTGTCTGATGCA
CTGTATGCGGCCTCCCTGCCGCTGCTGGTCTATTACTACGCCCGCGGCGACCACTGGCCC
TTCAGCACGGTGCTCTGCAAGCTGGTGCGCTTCCTCTTCTACACCAACCTTTACTGCAGC
ATCCTCTTCCTCACCTGCATCAGCGTGCACCGGTGTCTGGGCGTCTTACGACCTCTGCGC
TCCCTGCGCTGGGGCCGGGCCCGCTACGCTCGCCGGGTGGCCGGGGCCGTGTGGGTGTTG
GTGCTGGCCTGCCAGGCCCCCGTGCTCTACTTTGTCACCACCAGCGCGCGCGGGGGCCGC
GTAACCTGCCACGACACCTCGGCACCCGAGCTCTTCAGCCGCTTCGTGGCCTACAGCTCA
GTCATGCTGGGCCTGCTCTTCGCGGTGCCCTTTGCCGTCATCCTTGTCTGTTACGTGCTC
ATGGCTCGGCGACTGCTAAAGCCAGCCTACGGGACCTCGGGCGGCCTCCCTAGGGCCAAG
CGCAAGTCCGTGCGCACCATCGCCGTGGTGCTGGCTGTCTTCGCCCTCTGCTTCCTGCCA
TTCCACGTCACCCGCACCCTCTACTACTCCTTCCGCTCGCTGGACCTCAGCTGCCACACC
CTCAACGCCATCAACATGGCCTACAAGGTTACCCGGCCGCTGGCCAGTGCTAACAGTTGC
CTTGACCCCGTGCTCTACTTCCTGGCTGGGCAGAGGCTCGTACGCTTTGCCCGAGATGCC
AAGCCACCCACTGGCCCCAGCCCTGCCACCCCGGCTCGCCGCAGGCTGGGCCTGCGCAGA
TCCGACAGAACTGACATGCAGAGGATAGGAGATGTGTTGGGCAGCAGTGAGGACTTCAGG
CGGACAGAGTCCACGCCGGCTGGTAGCGAGAACACTAAGGACATTCGGCTGTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
U07225

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_2_Locus:
11q13.5-q14.1

# Macromolecular_Interacting_Partner_2_SNPs:
rs1626154; rs2511241; rs3741156; rs1783596; rs17244555; rs35545480; rs1625496; rs1790080; rs1791926; rs1614862; rs1790081; rs12364461; rs4944022; rs12282907; rs12366239; rs2510883; rs1974427; rs4944831; rs10898908; rs1790078; rs1783597; rs1790082; rs508859; rs7111814; rs7130635; rs1790083; rs12277861; rs1790077; rs947850; rs1790070; rs7934507; rs7934353; rs10082637; rs7941277; rs480305; rs1790079; rs34082105; rs7126411; rs1971618; rs1790076; rs1981407; rs5792613; rs34703536; rs11274466; rs498145; rs12271747; rs7948393; rs507126; rs34529794; rs11355516; rs12365017; rs12277272; rs12222026; rs34656991; rs34770116; rs28498965; rs35116771; rs34972858; rs34144108; rs34683944; rs11444519; rs1790062; rs10898909; rs10898910; rs11235681; rs11235688; rs11235689; rs11602881; rs12271502; rs12361940; rs1790066; rs1790067; rs1790068; rs1790074; rs1790075; rs1790084; rs1790085; rs1791920; rs2013474; rs2510880; rs2510884; rs34380696; rs3814727; rs3814728; rs4382936; rs4944832; rs498323; rs521241; rs557451; rs558202; rs574722; rs580840; rs7103608; rs753004; rs7940905; rs949140; rs949141

# Macromolecular_Interacting_Partner_2_General_References:
8159738; 7809171

# Macromolecular_Interacting_Partner_2_References:
16831297

# Macromolecular_Interacting_Partner_3_ID:
8758

# Macromolecular_Interacting_Partner_3_Name:
Equilibrative nucleoside transporter 2

# Macromolecular_Interacting_Partner_3_Synonyms:
Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter; Equilibrative NBMPR-insensitive nucleoside transporter; Nucleoside transporter, ei-type; Solute carrier family 29 member 2; 36 kDa nucleolar protein HNP36; Hydrophobic nucleolar protein, 36 kDa; Delayed-early response protein 12

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC29A2

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Equilibrative nucleoside transporter 2
MARGDAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGNSTARILSTNHTG
PEDAFNFNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGSLLAILLLFALTAALVKVD
MSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLL
SMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQELETKAE
LLQSDENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLV
FTVTLSVFPAITAMVTSSTSPGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRL
LPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPR
QVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
456

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
50114

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.02

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
 Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_3_Signals:
1-24

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
13-33
70-90
99-119
124-144
162-182
193-213
291-311
324-344
360-380
386-406
432-452

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
2811137

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
S29A2_HUMAN (Q14542)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC29A2

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC29A2

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:11004

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Isoform 1:Cell membrane; multi-pass membrane protein. Isoform 2:Nucleus; nuclear membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1371 bp
ATGGCGCGAGGAGACGCCCCGCGGGACAGCTACCACCTGGTCGGGATCAGCTTCTTCATC
CTGGGGCTGGGCACCCTCCTTCCCTGGAACTTCTTCATCACCGCCATCCCGTACTTCCAG
GCGCGACTGGCCGGGGCCGGCAACAGCACAGCCAGGATCCTGAGCACCAACCACACGGGT
CCCGAGGATGCCTTCAACTTCAACAATTGGGTGACGCTGCTGTCCCAGCTGCCCCTGCTG
CTCTTCACCCTCCTCAACTCCTTCCTGTACCAGTGCGTCCCGGAGACGGTGCGCATTCTG
GGCAGCCTGCTGGCCATACTGCTGCTCTTTGCCCTGACAGCAGCGCTGGTCAAGGTGGAC
ATGAGCCCCGGACCCTTCTTCTCCATCACCATGGCCTCCGTCTGCTTCATCAACTCCTTC
AGTGCAGTCCTACAGGGCAGCCTCTTCGGGCAGCTGGGCACCATGCCCTCCACCTACAGC
ACCCTCTTCCTCAGCGGCCAGGGCCTGGCTGGGATCTTTGCTGCCCTTGCCATGCTCCTG
TCCATGGCCAGTGGCGTGGACGCCGAGACCTCTGCCCTGGGGTACTTTATCACGCCCTGT
GTGGGCATCCTCATGTCCATCGTGTGTTACCTGAGCCTGCCTCACCTGAAGTTTGCCCGC
TACTACCTGGCCAATAAATCATCCCAGGCCCAAGCTCAGGAGCTGGAGACCAAAGCTGAG
CTCCTCCAGTCTGATGAGAACGGGATTCCCAGTAGTCCCCAGAAAGTAGCTCTGACCCTG
GATCTTGACCTGGAGAAGGAGCCGGAATCAGAGCCAGATGAGCCCCAGAAGCCAGGAAAA
CCTTCAGTCTTCACTGTCTTCCAGAAGATCTGGCTGACAGCGCTGTGCCTTGTGTTGGTC
TTCACAGTCACCCTGTCCGTCTTCCCCGCCATCACAGCCATGGTGACCAGCTCCACCAGT
CCTGGGAAGTGGAGTCAGTTCTTCAACCCCATCTGCTGCTTCCTCCTCTTCAACATCATG
GACTGGCTGGGACGGAGCCTGACCTCTTACTTCCTGTGGCCAGACGAGGACAGCCGGCTG
CTGCCCCTGCTGGTCTGCCTGCGGTTCCTGTTCGTGCCCCTCTTCATGCTGTGCCACGTG
CCCCAGAGGTCCCGGCTGCCCATCCTCTTCCCACAGGATGCCTACTTCATCACCTTCATG
CTGCTCTTTGCCGTTTCTAATGGCTACCTGGTGTCCCTCACCATGTGCCTGGCGCCCAGG
CAGGTGCTGCCACACGAGAGGGAGGTGGCCGGCGCCCTCATGACCTTCTTCCTGGCCCTG
GGACTTTCCTGTGGAGCCTCCCTCTCCTTCCTCTTCAAGGCGCTGCTCTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF034102

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11q13

# Macromolecular_Interacting_Partner_3_SNPs:
rs8187661; rs1039593; rs3177514; rs4930358; rs7126064; rs2292123; rs2279861; rs2279862; rs7125100; rs7126018; rs12416747; rs1039594; rs10791872; rs8187658; rs3867130; rs12576299; rs1344410; rs12576293; rs12577196; rs4930178; rs4930359; rs12281049; rs4244813; rs7107191; rs7104297; rs17850744; rs17855425; rs12801227; rs34186490; rs34124904; rs11227466; rs4554890; rs3741366; rs10605893; rs11403442; rs7111197; rs10632640; rs35639157; rs35962792; rs7946434; rs33943132; rs34029417; rs1815807; rs35659701; rs7103571; rs35791794; rs10648232; rs11423263; rs34482391; rs1566871; rs11298226; rs12800796; rs35509820; rs11461356; rs35457397; rs1201452; rs1210071; rs34585457; rs12360603; rs1047029; rs10791871; rs12794121; rs34272485; rs7130857; rs8187644; rs8187646; rs8187647; rs8187657; rs8187659; rs8187660

# Macromolecular_Interacting_Partner_3_General_References:
9478986; 9396714; 7639753

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8857

# Macromolecular_Interacting_Partner_4_Name:
Equilibrative nucleoside transporter 3

# Macromolecular_Interacting_Partner_4_Synonyms:
Solute carrier family 29 member 3

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC29A3

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Equilibrative nucleoside transporter 3
MAVVSEDDFQHSSNSTYRTTSSSLRADQEALLEKLLDRPPPGLQRPEDRFCGTYIIFFSL
GIGSLLPWNFFITAKEYWMFKLRNSSSPATGEDPEGSDILNYFESYLAVASTVPSMLCLV
ANFLLVNRVAVHIRVLASLTVILAIFMVITALVKVDTFSWTRGFFAVTIVCMVILSGAST
VFSSSIYGMTGSFPMRNSQALISGGAMGGTVSAVASLVDLAASSDVRNSALAFFLTATIF
LVLCMGLYLLLSRLEYARYYMRPVLAAHVFSGEEELPQDSLSAPSVASRFIDSHTPPLRP
ILKKTASLGFCVTYVFFITSLIYPAVCTNIESLNKGSGSLWTTKFFIPLTTFLLYNFADL
CGRQLTAWIQVPGPNSKALPGFVLLRTCLIPLFVLCNYQPRVHLKTVVFQSDVYPALLSS
LLGLSNGYLSTLALLYGPKIVPRELAEATGVVMSFYVCLGLTLGSACSTLLVHLI

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
475

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
51875

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
7.85

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
 Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter)

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_4_Signals:
Not Available

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
50-72
107-126
131-153
163-185
198-220
230-252
308-330
340-357
378-395
415-437
450-472

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
12656639

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
S29A3_HUMAN (Q9BZD2)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC29A3

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC29A3

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:23096

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1428 bp
ATGGCCGTTGTCTCAGAGGACGACTTTCAGCACAGTTCAAACTCCACCTACAGAACCACA
AGCAGCAGTCTCCGAGCTGACCAGGAGGCACTGCTTGAGAAGCTGCTGGACCGCCCGCCC
CCTGGCCTGCAGAGGCCCGAGGACCGCTTCTGTGGCACATACATCATCTTCTTCAGCCTG
GGCATTGGCAGTCTACTGCCATGGAACTTCTTTATCACTGCCAAGGAGTACTGGATGTTC
AAACTCCGCAACTCCTCCAGCCCAGCCACCGGGGAGGACCCTGAGGGCTCAGACATCCTG
AACTACTTTGAGAGCTACCTTGCCGTTGCCTCCACCGTGCCCTCCATGCTGTGCCTGGTG
GCCAACTTCCTGCTTGTCAACAGGGTTGCAGTCCACATCCGTGTCCTGGCCTCACTGACG
GTCATCCTGGCCATCTTCATGGTGATAACTGCACTGGTGAAGGTGGACACTTTCTCCTGG
ACCCGTGGCTTTTTTGCGGTCACCATTGTCTGCATGGTGATCCTCAGCGGTGCCTCCACT
GTCTTCAGCAGCAGCATCTACGGCATGACCGGCTCCTTTCCTATGAGGAACTCCCAGGCA
CTGATATCAGGAGGAGCCATGGGCGGGACGGTCAGCGCCGTGGCCTCATTGGTGGACTTG
GCTGCATCCAGTGATGTGAGGAACAGCGCCCTGGCCTTCTTCCTGACGGCCACCATCTTC
CTCGTGCTCTGCATGGGACTCTACCTGCTGCTGTCCAGGCTGGAGTATGCCAGGTACTAC
ATGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGAAGAGGAGCTTCCCCAGGACTCC
CTCAGTGCCCCTTCGGTGGCCTCCAGATTCATTGATTCCCACACACCCCCTCTCCGCCCC
ATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGTCTTCTTCATCACCAGC
CTCATCTACCCCGCCGTCTGCACCAACATCGAGTCCCTCAACAAGGGCTCGGGCTCACTG
TGGACCACCAAGTTTTTCATCCCCCTCACTACCTTCCTCCTGTACAACTTTGCTGACCTA
TGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAATAGCAAGGCGCTCCCA
GGGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTTCGTGCTCTGTAACTACCAGCCC
CGCGTCCACCTGAAGACTGTGGTCTTCCAGTCCGATGTGTACCCCGCACTCCTCAGCTCC
CTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCTCTACGGGCCTAAGATT
GTGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGATGTCCTTTTATGTGTGCTTGGGC
TTAACACTGGGCTCAGCCTGCTCTACCCTCCTGGTGCACCTCATCTAG

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
AF326987

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_4_Locus:
10q22.1

# Macromolecular_Interacting_Partner_4_SNPs:
rs2487068; rs2252996; rs780668; rs2277257; rs999940; rs16928737; rs2252997; rs1084004; rs2275579; rs780680; rs780664; rs1538899; rs780660; rs780659; rs780666; rs703257; rs780654; rs946875; rs703256; rs2394793; rs7069807; rs1110399; rs780677; rs4600131; rs780675; rs2243460; rs780670; rs780676; rs6480510; rs2487067; rs6480511; rs809691; rs883764; rs7086724; rs12256138; rs2012500; rs780662; rs4494244; rs780672; rs780653; rs3781314; rs2249987; rs1538895; rs2066211; rs780655; rs10823723; rs1316421; rs11815656; rs3824770; rs7100381; rs2250002; rs6480513; rs12251921; rs12767108; rs16928705; rs10999773; rs10999778; rs1572810; rs7076329; rs6480514; rs780667; rs7090745; rs2249882; rs883763; rs780679; rs780674; rs7080325; rs3781316; rs2249989; rs780678; rs11812689; rs780669; rs2487066; rs2243496; rs7067629; rs10999776; rs7095417; rs11594628; rs780665; rs4430425; rs4348816; rs780661; rs3781311; rs3781313; rs2249753; rs10999770; rs7091983; rs884031; rs3781324; rs780658; rs10999775; rs7072838; rs780671; rs946973; rs10740374; rs12252326; rs3781310; rs10999771; rs3781309; rs3781312; rs1890885; rs2243540; rs3758570; rs3781317; rs2066209; rs780656; rs7900534; rs7083031; rs2066210; rs6480512; rs12220541; rs884681; rs3781327; rs16928722; rs7068179; rs7090777; rs12249513; rs10740375; rs7913673; rs780673; rs10999777; rs10999781; rs780657; rs7090611; rs884680; rs3781326; rs7086520; rs7071162; rs7071738; rs2249752; rs12252139; rs17525188; rs12252279; rs2243485; rs7071979; rs10999772; rs3781325; rs7087714; rs7084342; rs4747148; rs7924115; rs946979; rs780681; rs1572812; rs35065420; rs6650127; rs34069552; rs10716665; rs35206666; rs12263170; rs10625840; rs34905233; rs11376986; rs35919163; rs5786035; rs34110374; rs12356731; rs35335105; rs12269478; rs12243734; rs34152212; rs7913062; rs3059614; rs12762394; rs7911708; rs7914132; rs4746081; rs7094989; rs35701283; rs12267767; rs12220170; rs7068296; rs34294547; rs35368644; rs41281300; rs3781318; rs4641383; rs7916422; rs34315182; rs10999774; rs35720104; rs10999769; rs35239123; rs7077024; rs3837344; rs7913610; rs10552605; rs10999779; rs780663; rs35509882; rs3893272; rs3059612; rs35156362; rs1609652; rs35485497; rs34058912; rs12243650; rs4147262; rs7903407; rs35942216; rs12763826; rs3837345; rs34297699; rs34965758; rs3824768; rs34491538; rs41300554; rs36074226; rs7095479; rs7067937; rs11296364; rs35855172; rs7897272; rs34640546; rs3781315; rs34395748; rs12355187; rs12261581; rs10686987; rs12779065; rs10999783; rs36087675; rs12762772; rs5786034; rs10999782; rs34650529; rs34632350; rs10553895; rs34721394; rs12249991; rs11593088; rs3059610; rs28708771; rs35956296; rs10999768; rs28688626; rs35685893; rs10823722; rs10999766; rs10999784; rs10999785; rs10999786; rs10999788; rs11595617; rs11816935; rs12098507; rs12254223; rs12412201; rs12414898; rs1538898; rs1609651; rs17546494; rs2185416; rs2248674; rs34217506; rs35016944; rs35685474; rs7079524; rs780682; rs780683; rs780687; rs780688; rs780689; rs780690; rs780692; rs780693; rs780694; rs780695; rs780697; rs780698; rs7895122; rs7899555; rs869545; rs946879

# Macromolecular_Interacting_Partner_4_General_References:
11396612; 12384580; 12975309

# Macromolecular_Interacting_Partner_4_References:
Not Available

End of HMDB00133

Beginning of HMDB00134
# Accession_No:
HMDB00134

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-17 13:15:20

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Fumaric acid

# Description:
A precursor to L-malate in the Krebs tricarboxylic acid cycle. It is formed by the oxidation of succinate by succinate dehydrogenase. Fumarate is converted by fumarase to malate. A fumarate is a salt or ester of the organic compound fumaric acid, a dicarboxylic acid. (wikipedia)

# Synonyms:
(2E)-But-2-enedioate; (2E)-But-2-enedioic acid; (E)-2-Butenedioate; (E)-2-Butenedioic acid; 2-(E)-Butenedioate; 2-(E)-Butenedioic acid; Allomaleate; Allomaleic acid; Boletate; Boletic acid; FC 33; Fumarate; Fumaric acid; Lichenate; Lichenic acid; trans-1,2-Ethylenedicarboxylate; trans-1,2-Ethylenedicarboxylic acid; trans-2-Butenedioate; trans-2-Butenedioic acid; trans-Butenedioate; trans-Butenedioic acid; sodium fumarate

# Chemical_IUPAC_Name:
(E)-2-Butenedioic acid

# Chemical_Formula:
C4H4O4

# Chemical_Structure:
tbl_chemical:::HMDB00134_ZOOM.png:::119283210912056002

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00134_THUMB.png:::119283210740499624

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
carboxylic acid; alkene

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
116.01096

# Molecular_Weight_Avg:
116.07216

# Smiles_String_isomeric:
OC(=O)C=CC(O)=O

# Smiles_String_canonical:
OC(=O)C=CC(O)=O

# KEGG_Compound_ID:
C00122

# BioCyc_ID:
FUM

# PubChem_CID:
723

# PubChem_SID:
11452343; 3422; 4579; 11406632; 7849367; 2920; 11451277; 5541333; 2725

# OMIM_ID:
Not Available

# Metagene_ID:
2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY: 401; PYRUVATE CARBOXYLASE DEFICIENCY: 109; FUMARIC ACIDURIA: 31

# BiGG_ID:
33938

# Wikipedia_ID:
Fumaric acid

# METLIN_ID:
3242

# Ref_ID:
8087979; 9693263; 2026685; 8412012

# ChEBI_ID:
29806

# CAS_Registry_Number:
110-17-8

# InChI:
InChI=1/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)

# Synthesis_Reference:
Catalytic oxidations in aqueous solutions. I. The oxidation of furfural.     Milas, N. A.    Journal of the American Chemical Society  (1927),  49  2005-11.

# Melting_Point:
549 oC

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
7.0 mg/mL [US EPA (1981)]

# H2O_Solubility_Predicted:
24.1 mg/mL [Predicted by ALOGPS]

# phys_charge:
-2

# State:
Solid

# LogP:
0.46 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
0.21 [Predicted by ALOGPS]; -0.4 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Fumeric Acid.pdf:::1132562204745199067

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00134.mol:::117633451972676591

# SDF_File_[Text]:
tbl_chemical:::HMDB00134.sdf:::119283210422258103

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00134.pdb:::119283210574968223

# PDB_ID:
1D4E

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041002_P00_05_HW_1DP_PRESAT_expanded_2.gif:::114460742226363597

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041002_P00_05_HW_1DP_presat.zip:::1177710548163671532

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041002_P00_05_HW_1DP_Assigned.png:::114660383813728002

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041002_P00_05_HW_1DP_Presat.png:::115877609882613316

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041002_P00_05_HW_1DP_Presat.zip:::115877609884888823

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
tbl_cnmr:::041002_P00_05_HW_1DC_88.jpg:::114168476755550833

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041002_P00_05_HW_1DC_88.zip:::114168476751868755

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041002_P00_05_HW_1DC_88_Assigned.jpg:::114322952771569618

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041002_P00_05_HW_2DHSQC_304.jpg:::11456583348349024

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041002_P00_05_HW_2DHSQC_304.zip:::114565833484477951

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041002_P00_05_HW_2DHSQC_304_Assigned.jpg:::114565833498026241

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Fumaric Acid.gif:::1132732112750156375

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00134_peaks.txt:::1156309568965139986

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Fumaric Acid_C.gif:::1132737695993898572

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00134_peaks.txt:::115631075887748991

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00134L.png:::117555262490190473; Medium Energy:tbl_ms:::HMDB00134M.png:::117555267844838963; High Energy:tbl_ms:::HMDB00134H.png:::117555271446231320

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000083.png:::11689082614532810

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000083.txt:::116890826175020915

# Cellular_Location:
Cytoplasm (Predicted from LogP); mitochondria

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	0.1	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	0.95 +/- 0.93	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	2026685
Urine	10.4	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	8087979
Urine	0.7	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	0.5	umol/mmol_creatinine	Adolescent:13-18_yrs_old	Both	Normal	8087979
Urine	10.7	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	8087979
Blood	1.5 (0.0-4.0)	umol/L	Adult:>18_yrs_old	Both	Normal	8412012
Cerebrospinal_Fluid(CSF)	33.0 (9.00-57.0)	umol/L	Adult:>18_yrs_old	Both	Normal	9693263


# Concentration_[Abnormal]:
Urine	0.7 (0.0-4.0)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Lung Cancer	HMP experiment
Cerebrospinal_Fluid(CSF)	11.0 (2.00-20.0)	umol/L	Elderly:>65_yrs_old	Both	Dementia of Alzheimer type (DAT)	9693263


# Associated_Disorders:
Cerebral Palsy; Dementia of Alzheimer type (DAT); Fumaric Aciduria; Lung Cancer

# Pathway_Names:
Purine metabolism;Nicotinate and nicotinamide metabolism

# Pathway_Images:
Purine_Synthesis.jpg;Nicotinamide_synthesis_(NADH).jpg

# KEGG_Images:
map00230;map00760

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;Nicotinamide_synthesis_(NADH)_Graph.jpg

# Pathway_SBMLs:
Purine_Synthesis.xml;Nicotinamide_synthesis_(NADH).xml

# Metabolic_Enzyme_1_ID:
6125

# Metabolic_Enzyme_1_Name:
Queuine tRNA-ribosyltransferase

# Metabolic_Enzyme_1_Synonyms:
tRNA-guanine transglycosylase; Guanine insertion enzyme

# Metabolic_Enzyme_1_Gene_Name:
QTRT1

# Metabolic_Enzyme_1_Protein_Sequence:
>Queuine tRNAribosyltransferase
MRLVAECSRSRARAGELWLPHGTVATPVFMPVGTQATMKGITTEQLDALGCRICLGNTYH
LGLRPGPELIQKANGLHGFMNWPHNLLTDSGGFQMVSLVSLSEVTEEGVRFRSPYDGNET
LLSPEKSVQIQNALGSDIIMQLDDVVSSTVTGPRVEEAMYRSIRWLDRCIAAHQRPDKQN
LFAIIQGGLDADLRATCLEEMTKRDVPGFAIGGLSGGESKSQFWRMVALSTSRLPKDKPR
YLMGVGYATDLVVCVALGCDMFDCVFPTRTARFGSALVPTGNLQLRKKVFEKDFGPIDPE
CTCPTCQKHSRAFLHALLHSDNTAALHHLTVHNIAYQLQLMSAVRTSIVEKRFPDFVRDF
MGAMYGDPTLCPTWATDALASVGITLG

# Metabolic_Enzyme_1_Number_of_Residues:
387

# Metabolic_Enzyme_1_Molecular_Weight:
42492

# Metabolic_Enzyme_1_Theoretical_pI:
7.25

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
Function:  queuine tRNA-ribosyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA modification
Process:  queuosine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_1_Specific_Function:
Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)

# Metabolic_Enzyme_1_Pathway:
Not Available

# Metabolic_Enzyme_1_Reaction:
tRNA guanine + queuine = tRNA queuine + guanine

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01702:TGT

# Metabolic_Enzyme_1_Signals:
1-25

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.2.29

# Metabolic_Enzyme_1_GenBank_ID_Protein:
12597312

# Metabolic_Enzyme_1_SwissProt_ID:
TGT_HUMAN (Q9BXR0)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
QTRT1

# Metabolic_Enzyme_1_Geneatlas_id:
QTRT1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:23797

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1212 bp
ATGGCGGGAGCAGCTACCCAGGCTTCCCTGGAGTCGGCCCCACGGATCATGCGGCTGGTG
GCCGAATGCAGCCGCTCCAGGGCCCGGGCAGGCGAGCTGTGGCTGCCGCATGGGACAGTG
GCCACTCCTGTGTTCATGCCAGTGGGCACGCAGGCCACCATGAAGGGCATCACGACCGAA
CAGCTGGACGCTCTGGGTTGCCGCATCTGCCTGGGCAATACCTACCATCTGGGTCTAAGG
CCGGGACCCGAGCTGATCCAGAAAGCCAACGGTCTCCACGGCTTCATGAATTGGCCTCAT
AATCTGCTAACGGACAGCGGCGGTTTCCAGATGGTGTCGCTGGTGTCTCTGTCCGAGGTG
ACGGAGGAGGGCGTCCGCTTCCGCTCCCCCTACGACGGCAATGAGACCCTGCTGAGCCCG
GAGAAATCCGTGCAGATCCAGAATGCGCTGGGCTCGGACATCATCATGCAGCTGGACGAC
GTGGTTAGCAGTACTGTGACTGGGCCACGTGTGGAGGAGGCCATGTACAGGTCAATCCGC
TGGCTGGACCGGTGCATTGCAGCCCATCAGCGGCCGGACAAGCAGAACCTCTTCGCCATT
ATCCAGGGTGGGCTGGACGCAGATCTCCGGGCCACCTGCCTTGAAGAGATGACCAAGCGA
GACGTGCCTGGCTTCGCCATCGGGGGCCTGAGCGGGGGTGAGAGCAAGTCGCAGTTCTGG
CGGATGGTGGCGCTGAGCACCTCTCGGCTGCCGAAGGACAAGCCCCGATATCTGATGGGG
GTTGGCTATGCCACTGATCTGGTAGTCTGCGTGGCTCTTGGATGTGACATGTTCGACTGC
GTCTTCCCCACACGGACAGCGCGCTTTGGCTCTGCCCTGGTGCCCACTGGGAACCTGCAG
TTGAGGAAGAAGGTGTTTGAGAAGGACTTCGGCCCCATAGACCCGGAGTGCACCTGCCCC
ACGTGCCAAAAGCACAGCCGCGCCTTCCTGCACGCACTGCTGCACAGTGACAACACGGCC
GCGCTGCACCACCTCACGGTCCACAACATCGCCTACCAGCTGCAGCTCATGAGCGCCGTC
CGCACCAGCATCGTGGAGAAGCGCTTCCCGGACTTCGTGCGGGACTTCATGGGCGCCATG
TACGGGGATCCCACCCTCTGTCCCACCTGGGCCACTGACGCTCTGGCCTCTGTGGGAATC
ACACTTGGCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF302783

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_1_Locus:
19p13.3

# Metabolic_Enzyme_1_SNPs:
rs11672431; rs892085; rs4425006; rs7251693; rs8102099; rs17698215; rs9807841; rs8113618; rs11671350; rs10407005; rs11671968; rs6511709; rs11085744; rs4804520; rs11542288; rs11542289; rs7251206; rs34948949; rs35623705; rs34512790; rs34502612; rs892083; rs7259597; rs35987639; rs12978496; rs34513131; rs35329214; rs7359857; rs34783161; rs36011736; rs35323929; rs35721659; rs35287850; rs35419154; rs34766302; rs11085745; rs12974306; rs13465; rs2010492

# Metabolic_Enzyme_1_General_References:
11255023

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5806

# Metabolic_Enzyme_2_Name:
Thymidine phosphorylase precursor

# Metabolic_Enzyme_2_Synonyms:
TdRPase; TP; Platelet-derived endothelial cell growth factor; PD-ECGF; Gliostatin

# Metabolic_Enzyme_2_Gene_Name:
ECGF1

# Metabolic_Enzyme_2_Protein_Sequence:
>Thymidine phosphorylase precursor
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ

# Metabolic_Enzyme_2_Number_of_Residues:
482

# Metabolic_Enzyme_2_Molecular_Weight:
49956

# Metabolic_Enzyme_2_Theoretical_pI:
5.19

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  pyrimidine base metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis

# Metabolic_Enzyme_2_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_2_Reaction:
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF02885:Glycos_trans_3N;
PF00591:Glycos_transf_3;
PF07831:PYNP_C

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.4.2.4

# Metabolic_Enzyme_2_GenBank_ID_Protein:
189701

# Metabolic_Enzyme_2_SwissProt_ID:
TYPH_HUMAN (P19971)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ECGF1

# Metabolic_Enzyme_2_Geneatlas_id:
ECGF1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:3148

# Metabolic_Enzyme_2_PDB_ID:
1UOU

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>1449 bp
ATGGCAGCCTTGATGACCCCGGGAACCGGGGCCCCACCCGCGCCTGGTGACTTCTCCGGG
GAAGGGAGCCAGGGACTTCCCGACCCTTCGCCAGAGCCCAAGCAGCTCCCGGAGCTGATC
CGCATGAAGCGAGACGGAGGCCGCCTGAGCGAAGCGGACATCAGGGGCTTCGTGGCCGCT
GTGGTGAATGGGAGCGCGCAGGGCGCACAGATCGGGGCCATGCTGATGGCCATCCGACTT
CGGGGCATGGATCTGGAGGAGACCTCGGTGCTGACCCAGGCCCTGGCTCAGTCGGGACAG
CAGCTGGAGTGGCCAGAGGCCTGGCGCCAGCAGCTTGTGGACAAGCATTCCACAGGGGGT
GTGGGTGACAAGGTCAGCCTGGTCCTCGCACCTGCCCTGGCGGCATGTGGCTGCAAGGTG
CCAATGATCAGCGGACGTGGTCTGGGGCACACAGGAGGCACCTTGGATAAGCTGGAGTCT
ATTCCTGGATTCAATGTCATCCAGAGCCCAGAGCAGATGCAAGTGCTGCTGGACCAGGCG
GGCTGCTGTATCGTGGGTCAGAGTGAGCAGCTGGTTCCTGCGGACGGAATCCTATATGCA
GCCAGAGATGTGACAGCCACCGTGGACAGCCTGCCACTCATCACAGCCTCCATTCTCAGT
AAGAAACTCGTGGAGGGGCTGTCCGCTCTGGTGGTGGACGTTAAGTTCGGAGGGGCCGCC
GTCTTCCCCAACCAGGAGCAGGCCCGGGAGCTGGCAAAGACGCTGGTTGGCGTGGGAGCC
AGCCTAGGGCTTCGGGTCGCGGCAGCGCTGACCGCCATGGACAAGCCCCTGGGTCGCTGC
GTGGGCCACGCCCTGGAGGTGGAGGAGGCGCTGCTCTGCATGGACGGCGCAGGCCCGCCA
GACTTAAGGGACCTGGTCACCACGCTCGGGGGCGCCCTGCTCTGGCTCAGCGGACACGCG
GGGACTCAGGCTCAGGGCGCTGCCCGGGTGGCCGCGGCGCTGGACGACGGCTCGGCCCTT
GGCCGCTTCGAGCGGATGCTGGCGGCGCAGGGCGTGGATCCCGGTCTGGCCCGAGCCCTG
TGCTCGGGAAGTCCCGCAGAACGCCGGCAGCTGCTGCCTCGCGCCCGGGAGCAGGAGGAG
CTGCTGGCGCCCGCAGATGGCACCGTGGAGCTGGTCCGGGCGCTGCCGCTGGCGCTGGTG
CTGCACGAGCTCGGGGCCGGGCGCAGCCGCGCTGGGGAGCCGCTCCGCCTGGGGGTGGGC
GCAGAGCTGCTGGTCGACGTGGGTCAGAGGCTGCGCCGTGGGACCCCCTGGCTCCGCGTG
CACCGGGACGGCCCCGCGCTCAGCGGCCCGCAGAGCCGCGCCCTGCAGGAGGCGCTCGTA
CTCTCCGACCGCGCGCCATTCGCCGCCCCCTCGCCCTTCGCAGAGCTCGTTCTGCCGCCG
CAGCAATAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M63193

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_2_Locus:
22q13|22q13.33

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
2467210; 1570012; 1400349; 1590793; 9924029; 12177387

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5715

# Metabolic_Enzyme_3_Name:
Hypoxanthine-guanine phosphoribosyltransferase

# Metabolic_Enzyme_3_Synonyms:
HGPRT; HGPRTase

# Metabolic_Enzyme_3_Gene_Name:
HPRT1

# Metabolic_Enzyme_3_Protein_Sequence:
>Hypoxanthineguanine phosphoribosyltransferase
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA

# Metabolic_Enzyme_3_Number_of_Residues:
218

# Metabolic_Enzyme_3_Molecular_Weight:
24580

# Metabolic_Enzyme_3_Theoretical_pI:
6.67

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
Function:  hypoxanthine phosphoribosyltransferase activity
 ||
>>>
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  purine salvage
Process:  purine ribonucleoside salvage
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_3_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
IMP + diphosphate = hypoxanthine + 5-phospho- alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_3_Reaction:
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00156:Pribosyltran

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.4.2.8

# Metabolic_Enzyme_3_GenBank_ID_Protein:
306885

# Metabolic_Enzyme_3_SwissProt_ID:
HPRT_HUMAN (P00492)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
HPRT1

# Metabolic_Enzyme_3_Geneatlas_id:
HPRT1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:5157

# Metabolic_Enzyme_3_PDB_ID:
1BZY

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>657 bp
ATGGCGACCCGCAGCCCTGGCGTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGAT
TTATTTTGCATACCTAATCATTATGCTGAGGATTTGGAAAGGGTGTTTATTCCTCATGGA
CTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCAT
CACATTGTAGCCCTCTGTGTGCTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGAT
TACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACTGTAGATTTTATC
AGACTGAAGAGCTATTGTAATGACCAGTCAACAGGGGACATAAAAGTAATTGGTGGAGAT
GATCTCTCAACTTTAACTGGAAAGAATGTCTTGATTGTGGAAGATATAATTGACACTGGC
AAAACAATGCAGACTTTGCTTTCCTTGGTCAGGCAGTATAATCCAAAGATGGTCAAGGTC
GCAAGCTTGCTGGTGAAAAGGACCCCACGAAGTGTTGGATATAAGCCAGACTTTGTTGGA
TTTGAAATTCCAGACAAGTTTGTTGTAGGATATGCCCTTGACTATAATGAATACTTCAGG
GATTTGAATCATGTTTGTGTCATTAGTGAAACTGGAAAAGCAAAATACAAAGCCTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M31642

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_3_Locus:
Xq26.1

# Metabolic_Enzyme_3_SNPs:
rs17882614; rs17324664; rs1468266; rs6638240; rs6638244; rs629; rs12687175; rs2070888; rs17882706; rs17879768; rs6638243; rs6634993; rs2283774; rs2515695; rs17324671; rs17000619; rs17879343; rs17881098; rs17883992; rs17882148; rs6634992; rs17885981; rs17879832; rs17879883; rs17882974; rs17879054; rs6654281; rs17885745; rs17878776; rs17885116; rs17882408; rs17883944; rs17879655; rs17879788; rs17885487; rs17879062; rs12383909; rs17882655; rs6638248; rs17879889; rs6638241; rs17880246; rs17879587; rs12008402; rs17885587; rs17879537; rs17885351; rs17879338; rs17886003; rs17884897; rs17879126; rs17884671; rs17878519; rs17885249; rs17878726; rs17882575; rs630; rs17879579; rs17885481; rs17882577; rs17882724; rs17880173; rs17882449; rs17878366; rs17883719; rs17882059; rs17885063; rs17878341; rs17885117; rs17882713; rs17882954; rs17878494; rs17882387; rs17879006; rs17886404; rs17879389; rs17885867; rs17883942; rs17878843; rs17885455; rs17882760; rs17884775; rs6634990; rs6634995; rs17878582; rs17878883; rs17882358; rs17879110; rs17881011; rs35095771; rs41299094; rs17879494; rs17878772; rs11369747; rs12839009; rs17880167; rs17882944; rs17881023; rs374290; rs35009311; rs17883755; rs12861067; rs17882363; rs34425749; rs34838035; rs366687; rs6638242; rs17879610; rs28478865; rs17887208; rs405630; rs12380958; rs5903878; rs17878547; rs35869442; rs387714; rs35585686; rs6634994; rs17882487; rs17879085; rs5978009; rs5933415; rs17883196; rs116493; rs5933416; rs12836923; rs12381664; rs35238558; rs17882186; rs373901; rs35653185; rs17881003; rs6638245; rs35325865; rs35834777; rs11406107; rs17884978; rs17885259; rs17882884; rs17883708; rs12836918; rs391918; rs34619253; rs377106; rs35538011; rs17884910; rs398712; rs5933414; rs35832135; rs17885490; rs12381784; rs377103; rs5903877; rs17880051; rs12838998; rs17878536; rs11344152; rs2503983; rs36109224; rs17884854; rs17878792; rs17878589; rs7472760; rs28663133; rs117407; rs17881034; rs12381662; rs17886030; rs6638246; rs17885101; rs17879848; rs17879532; rs17882283; rs417522; rs17878403; rs414365; rs5978007; rs398716; rs7357883; rs10482430; rs12689866; rs12847109; rs437849; rs4829768; rs6634997; rs6638238

# Metabolic_Enzyme_3_General_References:
6300847; 2341149; 7107641; 3023844; 8044844; 10360366; 10338013; 1487231; 6853490; 6853716; 6572373; 6706936; 3358423; 3384338; 3265398; 2896620; 3198771; 3148064; 2572141; 2909537; 2910902; 2738157; 2928313; 2347587; 2358296; 2246854; 2018042; 2071157; 1937471; 1840476; 1551676; 1301916; 7627191; 9003484; 9452051

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5805

# Metabolic_Enzyme_4_Name:
Purine nucleoside phosphorylase

# Metabolic_Enzyme_4_Synonyms:
Inosine phosphorylase; PNP

# Metabolic_Enzyme_4_Gene_Name:
NP

# Metabolic_Enzyme_4_Protein_Sequence:
>Purine nucleoside phosphorylase
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS

# Metabolic_Enzyme_4_Number_of_Residues:
289

# Metabolic_Enzyme_4_Molecular_Weight:
32118

# Metabolic_Enzyme_4_Theoretical_pI:
6.95

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  purine-nucleoside phosphorylase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_4_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_4_Reaction:
purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00896:Mtap_PNP

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.4.2.1

# Metabolic_Enzyme_4_GenBank_ID_Protein:
35565

# Metabolic_Enzyme_4_SwissProt_ID:
PNPH_HUMAN (P00491)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
NP

# Metabolic_Enzyme_4_Geneatlas_id:
NP

# Metabolic_Enzyme_4_hgnc_id:
HGNC:7892

# Metabolic_Enzyme_4_PDB_ID:
1RT9

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>870 bp
ATGGAGAACGGATACACCTATGAAGATTATAAGAACACTGCAGAATGGCTTCTGTCTCAT
ACTAAGCACCGACCTCAAGTTGCAATAATCTGTGGTTCTGGATTAGGAGGTCTGACTGAT
AAATTAACTCAGGCCCAGATCTTTGACTACAGTGAAATCCCCAACTTTCCTCGAAGTACA
GTGCCAGGTCATGCTGGCCGACTGGTGTTTGGGTTCCTGAATGGCAGGGCCTGTGTGATG
ATGCAGGGCAGGTTCCACATGTATGAAGGGTACCCACTCTGGAAGGTGACATTCCCAGTG
AGGGTTTTCCACCTTCTGGGTGTGGACACCCTGGTAGTCACCAATGCAGCAGGAGGGCTG
AACCCCAAGTTTGAGGTTGGAGATATCATGCTGATCCGTGACCATATCAACCTACCTGGT
TTCAGTGGTCAGAACCCTCTCAGAGGGCCCAATGATGAAAGGTTTGGAGATCGTTTCCCT
GCCATGTCTGATGCCTACGACCGGACTATGAGGCAGAGGGCTCTCAGTACCTGGAAACAA
ATGGGGGAGCAACGTGAGCTACAGGAAGGCACCTATGTGATGGTGGCAGGCCCCAGCTTT
GAGACTGTGGCAGAATGTCGTGTGCTGCAGAAGCTGGGAGCAGACGCTGTTGGCATGAGT
ACAGTACCAGAAGTTATCGTTGCACGGCACTGTGGACTTCGAGTCTTTGGCTTCTCACTC
ATCACTAACAAGGTCATCATGGATTATGAAAGCCTGGAGAAGGCCAACCATGAAGAAGTC
TTAGCAGCTGGCAAACAAGCTGCACAGAAATTGGAACAGTTTGTCTCCATTCTTATGGCC
AGCATTCCACTCCCTGACAAAGCCAGTTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
X00737

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_4_Locus:
14q13.1

# Metabolic_Enzyme_4_SNPs:
rs1049564; rs1130650; rs1049562; rs7785; rs1617940; rs1760940; rs1713420; rs1760935; rs1713422; rs1713421; rs3790064; rs3790065; rs1713429; rs17882804; rs17880405; rs1756369; rs12147688; rs8008133; rs17881431; rs17881345; rs7154909; rs17883821; rs17885781; rs1760934; rs17879107; rs17880844; rs17879913; rs17881184; rs17885714; rs17880480; rs17883253; rs17878900; rs1713426; rs17881356; rs1713427; rs1760933; rs3790062; rs17883795; rs17112168; rs17880290; rs12147906; rs17881554; rs17881206; rs1049700; rs17882836; rs12101049; rs17884106; rs12147035; rs34480769; rs3838361; rs3842517; rs1760939; rs17885917; rs17886095; rs1760938; rs17883294; rs17883604; rs8019880; rs17881280; rs35549071; rs35139440; rs17880503; rs7151666; rs10498268; rs1079375; rs1079376; rs11846743; rs11850059; rs11850069; rs12587218; rs12886203; rs12888804; rs12891271; rs13379232; rs13379234; rs1629478; rs17112384; rs17112385; rs1713459; rs1713460; rs1713461; rs1713462; rs17242655; rs17242662; rs17242669; rs1756365; rs1760930; rs1760931; rs1760941; rs1760942; rs2077153; rs2481768; rs35175606; rs35567022; rs7156659; rs755777

# Metabolic_Enzyme_4_General_References:
6087295; 3029074; 12928150; 2104852; 1384322; 8931706

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5963

# Metabolic_Enzyme_5_Name:
Guanine deaminase

# Metabolic_Enzyme_5_Synonyms:
Guanase; Guanine aminase; Guanine aminohydrolase; GAH; p51-nedasin

# Metabolic_Enzyme_5_Gene_Name:
GDA

# Metabolic_Enzyme_5_Protein_Sequence:
>Guanine deaminase
MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF
KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA
EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY
KETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSH
ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH
CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE
KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI
SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV

# Metabolic_Enzyme_5_Number_of_Residues:
454

# Metabolic_Enzyme_5_Molecular_Weight:
51004

# Metabolic_Enzyme_5_Theoretical_pI:
5.45

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia

# Metabolic_Enzyme_5_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_5_Reaction:
guanine + H2O = xanthine + ammonia

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01979:Amidohydro_1

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.5.4.3

# Metabolic_Enzyme_5_GenBank_ID_Protein:
4588080

# Metabolic_Enzyme_5_SwissProt_ID:
GUAD_HUMAN (Q9Y2T3)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
GDA

# Metabolic_Enzyme_5_Geneatlas_id:
GDA

# Metabolic_Enzyme_5_hgnc_id:
HGNC:4212

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_5_Gene_Sequence:
>1365 bp
ATGTGTGCCGCTCAGATGCCGCCCCTGGCGCACATCTTCCGAGGGACGTTCGTCCACTCC
ACCTGGACCTGCCCCATGGAGGTGCTGCGGGATCACCTCCTCGGCGTGAGCGACAGCGGC
AAAATAGTGTTTTTAGAAGAAGCATCTCAACAGGAAAAACTGGCCAAAGAATGGTGCTTC
AAGCCGTGTGAAATAAGAGAACTGAGCCACCATGAGTTCTTCATGCCTGGGCTGGTTGAT
ACACACATCCATGCCTCTCAGTATTCCTTTGCTGGAAGTAGCATAGACCTGCCACTCTTG
GAGTGGCTGACCAAGTACACATTTCCTGCAGAACACAGATTCCAGAACATCGACTTTGCA
GAAGAAGTATATACCAGAGTTGTCAGGAGAACACTAAAGAATGGAACAACCACAGCTTGT
TACTTTGCAACAATTCACACTGACTCATCTCTGCTCCTTGCCGACATTACAGATAAATTT
GGACAGCGGGCATTTGTGGGCAAAGTTTGCATGGATTTGAATGACACTTTTCCAGAATAC
AAGGAGACCACTGAGGAATCGATCAAGGAAACTGAGAGATTTGTGTCAGAAATGCTCCAA
AAGAACTATTCTAGAGTGAAGCCCATAGTGACACCACGTTTTTCCCTCTCCTGCTCTGAG
ACTTTGATGGGTGAACTGGGCAACATTGCTAAAACCCGTGATTTGCACATTCAGAGCCAT
ATAAGTGAAAATCGTGATGAAGTTGAAGCTGTGAAAAACTTATACCCCAGTTATAAAAAC
TACACATCTGTGTATGATAAAAACAATCTTTTGACAAATAAGACAGTGATGGCACACGGC
TGCTACCTCTCTGCAGAAGAACTGAACGTATTCCATGAACGAGGAGCATCCATCGCACAC
TGTCCCAATTCTAATTTATCGCTCAGCAGTGGATTTCTAAATGTGCTAGAAGTCCTGAAA
CATGAAGTCAAGATAGGGCTGGGTACAGACGTGGCTGGTGGCTATTCATATTCCATGCTT
GATGCAATCAGAAGAGCAGTGATGGTTTCCAATATCCTTTTAATTAATAAGGTAAATGAG
AAAAGCCTCACCCTCAAAGAAGTCTTCAGACTAGCTACTCTTGGAGGAAGCCAAGCCCTG
GGGCTGGATGGTGAGATTGGAAACTTTGAAGTGGGCAAGGAATTTGATGCCATCCTGATC
AACCCCAAAGCATCCGACTCTCCCATTGACCTGTTTTATGGGGACTTTTTTGGTGATATT
TCTGAGGCTGTTATCCAGAAGTTCCTCTATCTAGGAGATGATCGAAATATTGAAGAGGTT
TATGTGGGCGGAAAGCAGGTGGTTCCGTTTTCCAGCTCAGTGTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AF095286

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_5_Locus:
9q21.13

# Metabolic_Enzyme_5_SNPs:
rs2208744; rs1123; rs4484759; rs7029873; rs7038786; rs6560259; rs11143168; rs10869149; rs4579592; rs10869150; rs4744663; rs11143170; rs7030578; rs10869148; rs10781089; rs4314712; rs7862279; rs10781082; rs7031258; rs11143193; rs10781090; rs10869151; rs4130867; rs7874671; rs10781077; rs7023949; rs10781079; rs7030035; rs10869130; rs7853683; rs11143155; rs7019328; rs13298434; rs10869142; rs10781084; rs17494144; rs10781086; rs4130866; rs13284274; rs12338453; rs11143162; rs7019060; rs11143145; rs7861301; rs10781078; rs10735614; rs4545160; rs11143141; rs10746905; rs17494172; rs7025700; rs10781088; rs17057544; rs7048306; rs4745175; rs10869135; rs4503167; rs11143175; rs11143143; rs7862343; rs17579467; rs7867133; rs4540461; rs4427235; rs7857832; rs17494835; rs17579544; rs10781085; rs10781083; rs11143198; rs6560255; rs11143176; rs7032697; rs7849653; rs10869137; rs10781087; rs10869136; rs17057536; rs11143200; rs11143169; rs2295902; rs12343189; rs11143192; rs10869140; rs12347198; rs10869134; rs4745176; rs7847604; rs12380886; rs10122641; rs11143190; rs10869133; rs11143181; rs7048302; rs7036326; rs7862991; rs7868844; rs7019189; rs13292413; rs11143187; rs4618766; rs7043791; rs7847150; rs17579286; rs4287006; rs10869138; rs7873543; rs7863465; rs12379746; rs11143178; rs11143139; rs7872576; rs4607679; rs11143164; rs7024598; rs7872253; rs12000573; rs11143136; rs10869131; rs12684664; rs11143160; rs7851247; rs12555257; rs7866644; rs10735615; rs11143150; rs10746906; rs11143188; rs10869141; rs11143183; rs11790220; rs4745178; rs12000375; rs11143174; rs7027274; rs10869139; rs11143180; rs7023029; rs12341210; rs7863894; rs5025470; rs17057532; rs13295564; rs10869143; rs17057547; rs7039714; rs17494333; rs11143186; rs7034285; rs7847039; rs12551201; rs10781080; rs4347048; rs13439903; rs7862293; rs10869145; rs7870435; rs17057543; rs7034622; rs3802506; rs35577632; rs7023990; rs13298009; rs12551494; rs12684798; rs7848617; rs10869132; rs11143144; rs11143199; rs7863016; rs7848485; rs7036479; rs7021424; rs11143134; rs4745174; rs7042164; rs41287399; rs41310055; rs3830994; rs35479709; rs34771500; rs34826830; rs11143146; rs34464792; rs34994180; rs12340785; rs7030138; rs36108105; rs11143182; rs10120863; rs34896961; rs12236224; rs35055310; rs11143171; rs11143158; rs35815597; rs11143157; rs35560375; rs13286309; rs35376951; rs11143151; rs10544644; rs13289128; rs11143197; rs34517745; rs11143177; rs13301296; rs13285773; rs34453023; rs35580322; rs36066152; rs12336009; rs34935659; rs10869146; rs11143149; rs35080524; rs7868258; rs35540892; rs34401093; rs28894678; rs7023048; rs4132371; rs34172929; rs34039840; rs35534385; rs36023536; rs35976245; rs41287397; rs11143153; rs5898250; rs28595862; rs10588583; rs35929343; rs7868716; rs11310535; rs7028888; rs13286407; rs11143156; rs11327039; rs35402815; rs9695829; rs35490187; rs34627726; rs36053013; rs34208420; rs11793595; rs41287395; rs35963716; rs34340676; rs11143172; rs11442621; rs35458479; rs11143189; rs34611287; rs12347850; rs11143154; rs34151593; rs34139960; rs34656645; rs35345284; rs13294538; rs12683149; rs35587485; rs36095417; rs35458310; rs35936702; rs36057739; rs13292781; rs6560258; rs13301429; rs35524358; rs34395320; rs34584186; rs13299869; rs34271428; rs11143191; rs41287393; rs34922880; rs35383444; rs34193771; rs11143165; rs7041441; rs35909348; rs11143152; rs35111628; rs11143147; rs34847117; rs11143196; rs34236424; rs12339560; rs9696551; rs34248273; rs34537821; rs11411689; rs10566596; rs34979271; rs35740394; rs12339476; rs11143159; rs12238209; rs13299660; rs7046424; rs13299525; rs12376597; rs11143140; rs11310536; rs5898251; rs10588582; rs11143173; rs35059295; rs11143185; rs34971662; rs28735208; rs13299684; rs11143142; rs11143148; rs35948411; rs9775806; rs11788934; rs34554102; rs11794239; rs13290949; rs36110660; rs7862462; rs13284666; rs12237065; rs11143137; rs11143163; rs34354742; rs34021514; rs13290586; rs36027299; rs13283169; rs35528537; rs7861241; rs10548640; rs11143167; rs35547082; rs10614254; rs28723000; rs5898249; rs35288910; rs10714440; rs41287401; rs10116055; rs1040921; rs10511997; rs10781076; rs10781091; rs10869154; rs11143130; rs11143202; rs11143203; rs11143204; rs11143205; rs11788021; rs12001463; rs13283346; rs13287540; rs17057466; rs34380537; rs4745173; rs6560260; rs7029217; rs7030520; rs7047289; rs7849775; rs7850131; rs7850499; rs7863053; rs7863804; rs7868366; rs7868495; rs7869950; rs969460

# Metabolic_Enzyme_5_General_References:
10075721; 10542258

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5676

# Metabolic_Enzyme_6_Name:
Adenine phosphoribosyltransferase

# Metabolic_Enzyme_6_Synonyms:
APRT

# Metabolic_Enzyme_6_Gene_Name:
APRT

# Metabolic_Enzyme_6_Protein_Sequence:
>Adenine phosphoribosyltransferase
MADSELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDY
IAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTLWASYSLEYGKAELEIQKDALEPG
QRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSLKGREKLAPVPFFSLLQYE


# Metabolic_Enzyme_6_Number_of_Residues:
180

# Metabolic_Enzyme_6_Molecular_Weight:
19608

# Metabolic_Enzyme_6_Theoretical_pI:
5.82

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
Function:  adenine phosphoribosyltransferase activity
 ||
>>>
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  purine base metabolism
Process:  purine base salvage
Process:  adenine salvage
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

# Metabolic_Enzyme_6_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_6_Reaction:
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00156:Pribosyltran

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.4.2.7

# Metabolic_Enzyme_6_GenBank_ID_Protein:
28819

# Metabolic_Enzyme_6_SwissProt_ID:
APT_HUMAN (P07741)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
APRT

# Metabolic_Enzyme_6_Geneatlas_id:
APRT

# Metabolic_Enzyme_6_hgnc_id:
HGNC:626

# Metabolic_Enzyme_6_PDB_ID:
1ORE

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_6_Gene_Sequence:
>543 bp
ATGGCCGACTCCGAGCTGCAGCTGGTTGAGCAGCGGATCCGCAGCTTCCCCGACTTCCCC
ACCCCAGGCGTGGTATTCAGGGACATCTCGCCCGTCCTGAAGGACCCCGCCTCCTTCCGC
GCCGCCATCGGCCTCCTGGCGCGACACCTGAAGGCGACCCACGGGGGCCGCATCGACTAC
ATCGCAGGCCTAGACTCCCGAGGCTTCCTCTTTGGCCCCTCCCTGGCCCAGGAGCTTGGA
CTGGGCTGCGTGCTCATCCGAAAGCGGGGGAAGCTGCCAGGCCCCACTCTGTGGGCCTCC
TATTCCCTGGAGTACGGGAAGGCTGAGCTGGAGATTCAGAAAGACGCCCTGGAGCCAGGA
CAGAGGGTGGTCGTCGTGGATGATCTGCTGGCCACTGGTGGAACCATGAACGCTGCCTGT
GAGCTGCTGGGCCGCCTGCAGGCTGAGGTCCTGGAGTGCGTGAGCCTGGTGGAGCTGACC
TCGCTTAAGGGCAGGGAGAAGCTGGCACCTGTACCCTTCTTCTCTCTCCTGCAGTATGAG
TGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
Y00486

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_6_Locus:
16q24

# Metabolic_Enzyme_6_SNPs:
rs8191472; rs8191473; rs2242172; rs8191478; rs8191483; rs3214057; rs8191477; rs8191489; rs8191488; rs8191480; rs8191492; rs2242173; rs8191470; rs8191487; rs8191484; rs8191493; rs8191475; rs8191471; rs537641; rs3826075; rs564235; rs535070; rs8191463; rs3759950; rs541276; rs3759952; rs3759951; rs8191468; rs8191460; rs8191465; rs3826074; rs8191464; rs8191469; rs8191466; rs8191461; rs8191458; rs8191494; rs28999113; rs35148077; rs35095508; rs3169258; rs2911456; rs34926513; rs8191476; rs8191491; rs8191482; rs8191495; rs8191486; rs8191481; rs8191479; rs8191474; rs8191485; rs8191490; rs8191457; rs35132384; rs8191459; rs12929472; rs28712013; rs12929307; rs8191467; rs11076715; rs11076716; rs11076718; rs1141390; rs11640595; rs12932340; rs12935469; rs15829; rs1799825; rs1834065; rs2070256; rs2303271; rs2303272; rs2303273; rs3177509; rs3218720; rs3218721; rs3218722; rs3218723; rs3218724; rs3218725; rs3218726; rs3218727; rs3218728; rs3218729; rs3218730; rs3743548; rs3784890; rs3826065; rs3826066; rs3826067; rs3826068; rs3826069; rs3826070; rs3826071; rs4356464; rs4503779; rs4695; rs475667; rs480727; rs507329; rs510862; rs550269; rs555812; rs559678; rs565211; rs572275; rs8059203; rs8191502; rs8191504; rs8191509

# Metabolic_Enzyme_6_General_References:
3684585; 3554238; 3531209; 12665801; 1746557; 7915931; 3680503; 3343350; 1353080; 11243733

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
6277

# Metabolic_Enzyme_7_Name:
Cytochrome b

# Metabolic_Enzyme_7_Synonyms:
Not Available

# Metabolic_Enzyme_7_Gene_Name:
MT-CYB

# Metabolic_Enzyme_7_Protein_Sequence:
>Cytochrome b
MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDAS
TAFSSIAHIT
RDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIIL
LLATMATAFMGYVLPWGQMSF
WGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRF
FTFHFILPFIIAALATLHLLFLHETGSNNPLG
ITSHSDKITFHPYYTIKDALGLLLFLL
SLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTI
LRSVPNKLGGVLALLL
SILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTII
GQVAS
VLYFTTILILMPTISLIENKMLKWA

# Metabolic_Enzyme_7_Number_of_Residues:
380

# Metabolic_Enzyme_7_Molecular_Weight:
42730

# Metabolic_Enzyme_7_Theoretical_pI:
8.22

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_7_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_7_Specific_Function:
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
Not Available

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00032:Cytochrom_B_C;
PF00033:Cytochrom_B_N

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
33-55; 76-98; 113-135; 140-158; 178-200; 229-251; 288-310; 323-340; 350-372

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.10.2.2

# Metabolic_Enzyme_7_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_7_SwissProt_ID:
CYB_HUMAN (P00156)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
MT-CYB

# Metabolic_Enzyme_7_Geneatlas_id:
MT-CYB

# Metabolic_Enzyme_7_hgnc_id:
HGNC:7427

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Membrane

# Metabolic_Enzyme_7_Gene_Sequence:
Not Available

# Metabolic_Enzyme_7_GenBank_ID_Gene:
V00662

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:MT

# Metabolic_Enzyme_7_Locus:
-

# Metabolic_Enzyme_7_SNPs:
Not Available

# Metabolic_Enzyme_7_General_References:
7219534; 10508508; 7623448; 7530363; 11130070; 11553319; 12022039; 6100559; 11047755; 1757091; 1732158; 8910895; 9818877; 9806551; 10453733; 10502593; 10960495; 11601507; 11464242

# Metabolic_Enzyme_7_References:
9531636

# Metabolic_Enzyme_8_ID:
6142

# Metabolic_Enzyme_8_Name:
Fumarate hydratase, mitochondrial precursor

# Metabolic_Enzyme_8_Synonyms:
Fumarase

# Metabolic_Enzyme_8_Gene_Name:
FH

# Metabolic_Enzyme_8_Protein_Sequence:
>Fumarate hydratase, mitochondrial precursor
MYRALRLLARSRPLVRAPAAALASAPGLGGAAVPSFWPPNAARMASQNSFRIEYDTFGEL
KVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAI
MKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDH
VNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAV
PLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAAL
TGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPE
NEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSA
RLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGS
TLKETAIELGYLTAEQFDEWVKPKDMLGPK

# Metabolic_Enzyme_8_Number_of_Residues:
510

# Metabolic_Enzyme_8_Molecular_Weight:
54638

# Metabolic_Enzyme_8_Theoretical_pI:
9.17

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-oxygen lyase activity
Function:  hydro-lyase activity
Function:  fumarate hydratase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  fumarate metabolism
 ||
>>>
Component:  protein complex
Component:  tricarboxylic acid cycle enzyme complex

# Metabolic_Enzyme_8_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_8_Specific_Function:
Also acts as a tumor suppressor

# Metabolic_Enzyme_8_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_8_Reaction:
(S)-malate = fumarate + H2O

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00206:Lyase_1

# Metabolic_Enzyme_8_Signals:
1-23

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 4.2.1.2

# Metabolic_Enzyme_8_GenBank_ID_Protein:
1545996

# Metabolic_Enzyme_8_SwissProt_ID:
FUMH_HUMAN (P07954)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
FH

# Metabolic_Enzyme_8_Geneatlas_id:
FH

# Metabolic_Enzyme_8_hgnc_id:
HGNC:3700

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Mitochondrion. Cytoplasm

# Metabolic_Enzyme_8_Gene_Sequence:
>1533 bp
ATGTACCGAGCACTTCGGCTCCTCGCGCGCTCGCGTCCCCTCGTGCGGGCTCCAGCCGCA
GCCTTAGCTTCGGCTCCCGGCTTGGGTGGCGCGGCCGTGCCCTCGTTTTGGCCTCCGAAC
GCGGCTCGAATGGCAAGCCAAAATTCCTTCCGGATAGAATATGATACCTTTGGTGAACTA
AAGGTGCCAAATGATAAGTATTATGGCGCCCAGACCGTGAGATCTACGATGAACTTTAAG
ATTGGAGGTGTGACAGAACGCATGCCAACCCCAGTTATTAAAGCTTTTGGCATCTTGAAG
CGAGCGGCCGCTGAAGTAAACCAGGATTATGGTCTTGATCCAAAGATTGCTAATGCAATA
ATGAAGGCAGCAGATGAGGTAGCTGAAGGTAAATTAAATGATCATTTTCCTCTCGTGGTA
TGGCAGACTGGATCAGGAACTCAGACAAATATGAATGTAAATGAAGTCATTAGCAATAGA
GCAATTGAAATGTTAGGAGGTGAACTTGGCAGCAAGATACCTGTGCATCCCAACGATCAT
GTTAATAAAAGCCAGAGCTCAAATGATACTTTTCCCACAGCAATGCACATTGCTGCTGCA
ATAGAAGTTCATGAAGTACTGTTACCAGGACTACAGAAGTTACATGATGCTCTTGATGCA
AAATCCAAAGAGTTTGCACAGATCATCAAGATTGGACGTACTCATACTCAGGATGCTGTT
CCACTTACTCTTGGGCAGGAATTTAGTGGTTATGTTCAACAAGTAAAATATGCAATGACA
AGAATAAAAGCTGCCATGCCAAGAATCTATGAGCTCGCAGCTGGAGGCACTGCTGTTGGT
ACAGGTTTAAATACTAGAATTGGCTTTGCAGAAAAGGTTGCTGCAAAAGTGGCTGCACTT
ACAGGCTTGCCTTTTGTCACTGCTCCGAATAAATTTGAAGCTCTGGCTGCTCATGACGCT
CTGGTTGAGCTCAGTGGAGCCATGAACACTACTGCCTGCAGTCTGATGAAGATAGCAAAT
GATATTCGATTTTTGGGTTCTGGTCCTCGGTCAGGTCTGGGAGAATTGATCTTGCCTGAA
AATGAACCAGGAAGCAGTATCATGCCAGGCAAGGTGAACCCTACTCAGTGTGAAGCAATG
ACCATGGTTGCAGCCCAAGTCATGGGGAACCATGTTGCTGTCACTGTCGGAGGCAGCAAT
GGACATTTTGAGTTGAATGTTTTCAAGCCAATGATGATTAAAAATGTGTTACACTCAGCC
AGGCTGCTGGGGGATGCTTCAGTTTCCTTTACAGAAAACTGCGTGGTGGGAATCCAGGCC
AATACAGAAAGGATCAACAAGCTGATGAATGAGTCTCTAATGTTGGTGACAGCTCTCAAT
CCTCATATAGGGTATGACAAGGCAGCAAAGATTGCTAAGACAGCACACAAAAATGGATCA
ACCTTAAAGGAAACTGCTATCGAACTTGGCTATCTCACAGCAGAGCAGTTTGACGAATGG
GTAAAACCTAAGGACATGCTGGGTCCAAAGTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
U59309

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_8_Locus:
1q42.1

# Metabolic_Enzyme_8_SNPs:
rs1335898; rs4659607; rs2994990; rs2992644; rs11802956; rs2185626; rs3014577; rs11810820; rs10802968; rs4660099; rs12563264; rs6673988; rs4659606; rs11810810; rs10926500; rs10926499; rs12065955; rs12062672; rs1572380; rs2275162; rs4659608; rs11809211; rs4660098; rs12072899; rs12059383; rs12085636; rs2225788; rs2153694; rs947306; rs7530270; rs6678986; rs2153695; rs12071124; rs7414794; rs6679186; rs6681649; rs11545656; rs11545658; rs11545659; rs11545654; rs11545655; rs10926501; rs1049719; rs12087951; rs36061522; rs35911339; rs35806536; rs34169563; rs11811744; rs3014576; rs34340049; rs34519169; rs2341940; rs6689999; rs36216713; rs5782200; rs34461266; rs28593473; rs12059375; rs35459191; rs5782199; rs12058914; rs35724406; rs34171219; rs5782201; rs12759839; rs12057640; rs6143706; rs2992645; rs11463263; rs2341941; rs12047049; rs12075683; rs10548903; rs35416457; rs34827919; rs10560801; rs12401442; rs10926503; rs16841808; rs12754502; rs34007305; rs5782198; rs34516025; rs10754730; rs11810451; rs1414493; rs2994986; rs2994989; rs4431830; rs4601574; rs4660101; rs6678766; rs6693420; rs7514407; rs7536335; rs9729137

# Metabolic_Enzyme_8_General_References:
3828494; 9635293; 11865300

# Metabolic_Enzyme_8_References:
10029537; 10533287; 10940008; 11084597

# Metabolic_Enzyme_9_ID:
6140

# Metabolic_Enzyme_9_Name:
NADP-dependent malic enzyme, mitochondrial precursor

# Metabolic_Enzyme_9_Synonyms:
NADP-ME; Malic enzyme 3

# Metabolic_Enzyme_9_Gene_Name:
ME3

# Metabolic_Enzyme_9_Protein_Sequence:
>NADPdependent malic enzyme, mitochondrial precursor
MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLN
KGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKL
FYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNI
KAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRD
PLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCM
FNDDIQGTASVAVAGILAALRITNNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKA
EATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGA
FTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGK
TFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLST
IRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMN
VQTV

# Metabolic_Enzyme_9_Number_of_Residues:
604

# Metabolic_Enzyme_9_Molecular_Weight:
67055

# Metabolic_Enzyme_9_Theoretical_pI:
7.92

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  malate dehydrogenase activity
Function:  malic enzyme activity
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  malate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_9_Specific_Function:
(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH

# Metabolic_Enzyme_9_Pathway:
map00620  Pyruvate metabolism;
 map00710  Carbon fixation

# Metabolic_Enzyme_9_Reaction:
(S)-malate + NADP+ = pyruvate + CO2 + NADPH

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00390:malic;
PF03949:Malic_M

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 1.1.1.40

# Metabolic_Enzyme_9_GenBank_ID_Protein:
535012

# Metabolic_Enzyme_9_SwissProt_ID:
MAON_HUMAN (Q16798)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
ME3

# Metabolic_Enzyme_9_Geneatlas_id:
ME3

# Metabolic_Enzyme_9_hgnc_id:
HGNC:6985

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_9_Gene_Sequence:
>1815 bp
ATGGGTGCCGCGCTGGGGACAGGCACGCGGCTGGCTCCCTGGCCGGGCCGGGCCTGCGGC
GCCCTCCCGCGCTGGACACCCACCGCGCCCGCCCAAGGCTGCCACTCCAAGCCTGGCCCG
GCGCGCCCTGTGCCCCTGAAGAAGCGCGGATACGATGTCACCAGGAACCCTCATCTCAAC
AAGGGGATGGCCTTTACCCTTGAAGAAAGGCTGCAGCTTGGAATCCACGGCCTAATCCCG
CCCTGCTTTCTGAGCCAGGACGTCCAGCTCCTCCGAATCATGAGATATTACGAGCGGCAG
CAGAGTGACCTGGACAAGTACATCATTCTCATGACACTCCAAGACCGGAACGAGAAGCTC
TTCTACCGAGTGCTGACTTCGGATGTGGAGAAGTTCATGCCAATCGTGTACACGCCTACC
GTGGGGCTGGCCTGTCAGCACTATGGCCTGACTTTCCGCAGGCCCCGTGGACTGTTCATC
ACCATTCATGACAAAGGTCATCTTGCAACAATGCTGAATTCTTGGCCAGAAGACAATATT
AAGGCCGTGGTGGTGACTGATGGGGAGCGCATCCTGGGCCTGGGAGACCTGGGCTGCTAC
GGCATGGGCATCCCTGTGGGCAAGCTGGCCCTGTACACGGCATGCGGAGGGGTGAACCCG
CAGCAGTGCCTCCCTGTGCTGCTGGACGTCGGCACCAACAATGAGGAGCTGCTCAGAGAC
CCTCTGTACATCGGCCTGAAACACCAGCGCGTGCACGGGAAGGCATACGATGACTTGCTG
GATGAGTTCATGCAGGCTGTGACAGACAAGTTTGGAATAAATTGCCTCATCCAATTTGAA
GACTTCGCCAATGCCAATGCCTTCCGCCTGCTCAACAAATACCGTAACAAGTACTGCATG
TTCAATGATGACATCCAAGGCACAGCCTCCGTTGCTGTGGCAGGGATCTTGGCTGCTCTG
CGAATCACCAACAACAAGCTTTCCAATCACGTGTTTGTTTTCCAAGGTGCAGGCGAGGCA
GCTATGGGCATTGCCCACCTCCTTGTCATGGCCCTAGAGAAAGAAGGTGTACCGAAGGCA
GAGGCCACAAGAAAGATCTGGATGGTGGACTCTAAAGGGCTCATTGTCAAGGGGAGGAGC
CACCTGAACCATGAAAAGGAGATGTTTGCCCAAGACCATCCTGAAGTCAACTCCCTGGAG
GAGGTGGTGAGGCTGGTGAAGCCCACAGCCATCATAGGTGTTGCTGCCATCGCAGGAGCC
TTCACGGAGCAGATTCTGAGGGACATGGCCTCCTTCCACGAGCGCCCTATCATCTTTGCC
CTGAGCAACCCCACCAGCAAGGCCGAGTGCACGGCTGAGAAGTGCTACCGGGTCACCGAG
GGCCGAGGGATTTTTGCCAGTGGAAGTCCTTTTAAGAGTGTGACTCTGGAAGATGGCAAG
ACCTTCATTCCTGGGCAGGGAAACAATGCTTACGTGTTCCCCGGGGTGGCACTGGGAGTC
ATCGCCGGCGGGATCCGGCACATCCCAGATGAGATCTTCCTCCTGACAGCAGAGCAAATT
GCCCAGGAAGTCTCTGAGCAGCATCTGTCCCAGGGGAGACTCTATCCACCACTCAGCACC
ATCCGAGACGTGTCTTTGAGAATTGCCATCAAAGTTCTCGACTACGCGTACAAACACAAC
CTGGCTTCCTACTACCCAGAGCCTAAGGACAAGGAGGCTTTTGTAAGATCCCTGGTCTAC
ACTCCAGACTATGACTCCTTTACACTGGACAGCTACACTTGGCCCAAGGAAGCCATGAAT
GTTCAGACGGTCTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
X79440

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_9_Locus:
11cen-q22.3

# Metabolic_Enzyme_9_SNPs:
rs1042780; rs4943943; rs17211115; rs7946487; rs12287767; rs34662182; rs2446230; rs1945034; rs632873; rs1541310; rs675775; rs677643; rs1541309; rs722158; rs1540082; rs1938921; rs1945142; rs659405; rs2051434; rs624183; rs553351; rs666472; rs587362; rs498981; rs1894012; rs618513; rs539805; rs1938935; rs2226566; rs663262; rs660372; rs679220; rs1938924; rs623478; rs525764; rs632538; rs2511090; rs681333; rs647561; rs658166; rs643414; rs609848; rs2156532; rs634509; rs1458382; rs999472; rs2078385; rs2446228; rs668753; rs601646; rs949349; rs1938931; rs582282; rs1938938; rs651089; rs1945036; rs611156; rs2032356; rs722157; rs622933; rs1938923; rs1938926; rs661163; rs601824; rs616018; rs679076; rs633708; rs538058; rs1841066; rs539939; rs590401; rs4319536; rs4944580; rs7123773; rs655934; rs7950878; rs3819227; rs10219305; rs10898524; rs7109270; rs10219173; rs3824954; rs672526; rs10898501; rs651758; rs609885; rs502749; rs949351; rs7948981; rs10792860; rs7120052; rs1945143; rs7120444; rs7940192; rs4944602; rs4439535; rs7951868; rs6592301; rs10898498; rs626049; rs2279046; rs7112309; rs4144867; rs625925; rs687804; rs493010; rs7122296; rs11607733; rs7940187; rs2446229; rs4944612; rs10898483; rs10898514; rs11234656; rs1945043; rs4944607; rs12285249; rs606546; rs601988; rs1542426; rs585218; rs7117375; rs10444375; rs1938928; rs4943949; rs2051433; rs6592296; rs4405344; rs6592295; rs10792865; rs10792866; rs7103271; rs11234707; rs7941337; rs2446225; rs658324; rs10219319; rs7937853; rs7109521; rs7105863; rs4944613; rs630438; rs7122406; rs4144866; rs2242142; rs7943741; rs1938927; rs10792861; rs638041; rs7940549; rs624843; rs7940654; rs7117234; rs7122928; rs12282010; rs7940523; rs10501627; rs10898484; rs4944596; rs7122479; rs7108055; rs669325; rs7941446; rs4382935; rs7949910; rs12417575; rs7108746; rs4944604; rs12361283; rs4592448; rs7925862; rs662361; rs588287; rs1540083; rs668272; rs6592294; rs4944609; rs7103017; rs611730; rs507123; rs7109853; rs1945145; rs7127944; rs636485; rs1006586; rs677700; rs9787905; rs7122239; rs4944592; rs585749; rs603241; rs1938929; rs2125363; rs601300; rs7106865; rs1458384; rs147045; rs949350; rs4382934; rs7935611; rs1938932; rs4944611; rs4144865; rs630454; rs10501625; rs2511082; rs1945146; rs657378; rs584953; rs7119775; rs605251; rs7116278; rs3758877; rs10898490; rs616794; rs12284853; rs1379872; rs12576144; rs10792854; rs7951185; rs4944593; rs1563682; rs7940587; rs676106; rs10898512; rs10792858; rs12575285; rs7940772; rs579719; rs11819827; rs612163; rs507211; rs7940781; rs11828425; rs12290684; rs6592297; rs10501621; rs7938505; rs659301; rs4245422; rs10792864; rs2168862; rs11825033; rs7117702; rs621653; rs7126717; rs503583; rs10219378; rs4245423; rs10501624; rs17149147; rs11606017; rs3781812; rs7937668; rs638492; rs11234691; rs4944600; rs672266; rs646691; rs613412; rs11826066; rs661328; rs631082; rs7115580; rs10898488; rs598187; rs635934; rs679382; rs10792857; rs4405345; rs10501620; rs10501628; rs628406; rs7930619; rs2279047; rs1945144; rs7118187; rs17819683; rs668270; rs597793; rs7944874; rs17149169; rs4944603; rs10444372; rs635637; rs12797615; rs683899; rs4245420; rs3781813; rs663208; rs647782; rs6592302; rs12804997; rs661954; rs10792856; rs10898515; rs10501623; rs7123010; rs4943945; rs7103556; rs591060; rs653715; rs4245418; rs7934133; rs17211577; rs7125366; rs11234702; rs17211570; rs2155035; rs610790; rs7126810; rs4944614; rs17149234; rs12289252; rs7130920; rs2840368; rs1006587; rs12420965; rs4245424; rs608180; rs561363; rs17819176; rs7940788; rs640310; rs1870323; rs2125362; rs11234662; rs4944610; rs10792855; rs679977; rs10501622; rs585527; rs597296; rs7940590; rs664613; rs7928552; rs10898500; rs593853; rs11821546; rs11234708; rs10792862; rs17149180; rs614995; rs11234719; rs17819523; rs767776; rs1458381; rs4944581; rs2279048; rs7102806; rs2446224; rs583594; rs10898496; rs10898516; rs10501626; rs4245421; rs624236; rs7115834; rs641541; rs10898485; rs10400291; rs10792863; rs17159928; rs11234658; rs7107136; rs1938922; rs7123044; rs12285344; rs677301; rs7941124; rs4245419; rs4944586; rs12281596; rs624870; rs7940448; rs9705039; rs1938925; rs12293809; rs17757676; rs2446226; rs11234676; rs7121583; rs11606042; rs9667152; rs2032355; rs9704409; rs11234731; rs589368; rs10898499; rs11234700; rs7930715; rs687138; rs3889658; rs628449; rs7925379; rs7924879; rs7103642; rs12801189; rs637693; rs12365092; rs531908; rs7949920; rs11234657; rs17818784; rs11234711; rs10898517; rs11234716; rs17211409; rs11234678; rs10444374; rs9645702; rs7128131; rs7116895; rs12798729; rs10898494; rs7130902; rs10898505; rs674250; rs11234683; rs17149242; rs12805940; rs4944616; rs11234729; rs11604162; rs11820663; rs10898507; rs642780; rs7941051; rs619195; rs535652; rs668984; rs11234704; rs7945440; rs969034; rs12291729; rs589174; rs681158; rs11234692; rs12419111; rs2125358; rs3824952; rs12573953; rs7480835; rs12365653; rs566633; rs7125970; rs10898508; rs12269800; rs4245417; rs648798; rs7108710; rs9667168; rs1938918; rs4944585; rs1824279; rs1945139; rs12792674; rs748102; rs12793144; rs12421147; rs7944836; rs590750; rs501362; rs7938344; rs11821635; rs674481; rs10444371; rs12419781; rs17211458; rs12574128; rs4944617; rs643950; rs10792871; rs7104141; rs12283397; rs11234665; rs4944595; rs9943610; rs12285306; rs7945240; rs7938901; rs11234701; rs4943946; rs7952019; rs10898513; rs9645703; rs1945138; rs17211053; rs7943403; rs2155033; rs2212341; rs7938741; rs11828773; rs17818845; rs682501; rs12808738; rs11602862; rs627684; rs4944594; rs12799562; rs1458383; rs11234715; rs9667489; rs10898502; rs1541308; rs1540081; rs12793707; rs7941576; rs10898518; rs2276394; rs511884; rs7926965; rs12364541; rs10898509; rs11234713; rs9667156; rs11234705; rs530278; rs4944587; rs644086; rs11234690; rs11234718; rs1350478; rs539214; rs4944582; rs12277137; rs11606745; rs2212340; rs12222139; rs673118; rs7945260; rs3824953; rs688079; rs12361416; rs12362293; rs661115; rs7948764; rs17149223; rs12420485; rs11234727; rs11234689; rs9943508; rs12804208; rs7935437; rs10898495; rs584068; rs503195; rs4944583; rs7927467; rs593450; rs12224723; rs17149245; rs10898510; rs2511083; rs11607554; rs594106; rs1938920; rs9667775; rs12797575; rs7930401; rs546427; rs4291698; rs11234686; rs12790474; rs4391846; rs11234699; rs1945137; rs10898503; rs11234714; rs7940800; rs12799435; rs7119485; rs4943955; rs12285279; rs2017483; rs7117143; rs12793198; rs7946685; rs7109555; rs7927796; rs11234726; rs998872; rs2446227; rs638135; rs17149197; rs12792300; rs670602; rs596056; rs7930654; rs3758878; rs480290; rs12226269; rs4944597; rs610476; rs2511081; rs751911; rs1938919; rs4944622; rs12288119; rs11602628; rs12280733; rs11234712; rs1945141; rs10898506; rs660893; rs9943611; rs17211563; rs7105382; rs12269985; rs17211584; rs605618; rs10792868; rs694952; rs12575580; rs17149130; rs17149226; rs1945035; rs610842; rs10898493; rs10898504; rs582976; rs7927795; rs12274942; rs17149238; rs10898511; rs653313; rs4943948; rs670736; rs1452138; rs684365; rs1452137; rs1452136; rs4943940; rs589887; rs12283035; rs4944578; rs11823255; rs12294756; rs682915; rs547591; rs7926796; rs12281645; rs10898525; rs35245729; rs3182235; rs15926; rs17852036; rs17845700; rs17856661; rs11556735; rs35059554; rs1062639; rs987649; rs685439; rs656307; rs5793201; rs646798; rs7924919; rs34470258; rs693052; rs12574675; rs7939530; rs11355612; rs11234687; rs34652301; rs618843; rs28895937; rs11518769; rs515798; rs3781806; rs12271274; rs11234668; rs36139518; rs11234673; rs9667498; rs12294332; rs2511089; rs623785; rs4483612; rs654286; rs496167; rs3862787; rs1902958; rs672264; rs34131458; rs12805450; rs582886; rs34631227; rs661972; rs7124538; rs35941464; rs11559614; rs1791443; rs11234709; rs10618233; rs7118346; rs12273697; rs9735826; rs34382146; rs10559080; rs12271571; rs659700; rs34909419; rs11234697; rs34838255; rs11383258; rs672280; rs10545624; rs680846; rs35804280; rs11459186; rs11234720; rs11359686; rs35420773; rs661083; rs4500512; rs12283825; rs28837406; rs34095490; rs12795419; rs618384; rs605255; rs11276982; rs4944620; rs28804208; rs10652368; rs1619882; rs34416639; rs2125360; rs2510498; rs35621612; rs34691357; rs4943952; rs34939684; rs7122008; rs11821842; rs12282012; rs12575681; rs12787395; rs11308452; rs11535845; rs11602146; rs7122667; rs34300602; rs35429348; rs658509; rs550761; rs34659727; rs35175493; rs35291772; rs12794991; rs597823; rs34754668; rs5793204; rs591474; rs10636674; rs657580; rs12362471; rs34832707; rs34557852; rs34946099; rs35892534; rs12294331; rs28603177; rs34313794; rs2219430; rs7934775; rs35187445; rs11234669; rs7929523; rs5793202; rs11601960; rs615371; rs34220027; rs34900435; rs34557683; rs2446231; rs11494278; rs11512936; rs35947577; rs3837399; rs9634021; rs3894263; rs11387187; rs10569902; rs6144422; rs12575999; rs5793205; rs12279297; rs11234664; rs12271552; rs28799720; rs4944590; rs34027067; rs35731805; rs11234696; rs35019870; rs602923; rs686768; rs643072; rs9667181; rs28678569; rs11369958; rs663543; rs12785372; rs4944588; rs11366218; rs2156531; rs11234660; rs12271548; rs34265019; rs604299; rs36152939; rs34764333; rs34278824; rs11392522; rs504635; rs12788873; rs17149146; rs2511085; rs4944579; rs34725712; rs11234721; rs35651342; rs642278; rs663073; rs11560984; rs12292032; rs7103785; rs12788651; rs1938934; rs28446263; rs35122148; rs11828585; rs10676754; rs11271121; rs2852378; rs34224480; rs683408; rs595031; rs11234677; rs617962; rs35557705; rs12269737; rs35393888; rs12417744; rs4943942; rs28825102; rs12804283; rs12804130; rs10672954; rs9705154; rs670825; rs12280101; rs35129724; rs12146569; rs28494065; rs4462374; rs35905440; rs471780; rs11512882; rs12271549; rs11532101; rs7115594; rs11530882; rs4944601; rs2511084; rs11234661; rs2305928; rs35463445; rs635971; rs36152806; rs7107161; rs34988004; rs34080694; rs34877706; rs35748086; rs36124549; rs12280500; rs34887500; rs34028266; rs5793206; rs2226858; rs34061130; rs12222903; rs34405620; rs3045014; rs35163253; rs12805420; rs1235409; rs35546812; rs7939052; rs11530863; rs12293152; rs11302044; rs12794525; rs604128; rs10601910; rs12804026; rs34349106; rs503155; rs34258229; rs653779; rs11512938; rs11234666; rs34699198; rs12291889; rs12362900; rs11234733; rs687669; rs28609643; rs10698015; rs12806468; rs10579155; rs642728; rs7112251; rs28583010; rs4943954; rs11533267; rs12791972; rs28716504; rs35269702; rs35968408; rs10653582; rs34393952; rs11501849; rs11234670; rs34996965; rs11234722; rs596322; rs10652369; rs5793209; rs7102548; rs487960; rs4944618; rs689039; rs34103747; rs12792567; rs34573490; rs12278573; rs35677637; rs34782520; rs12786394; rs10659565; rs34796489; rs4943941; rs35635737; rs12787475; rs10579052; rs35359440; rs627383; rs5793198; rs35222052; rs34315700; rs28452300; rs609855; rs11512934; rs4122041; rs503923; rs581796; rs11561000; rs629038; rs11234685; rs2511086; rs35870909; rs2105784; rs752519; rs12288171; rs679731; rs659781; rs33973657; rs4943950; rs35899335; rs12803885; rs12276356; rs10538002; rs34930310; rs11530862; rs12804089; rs7117530; rs2276393; rs1007948; rs3781808; rs34514194; rs36071853; rs34544991; rs10675389; rs12280100; rs10444373; rs12291626; rs35352939; rs582638; rs11603205; rs661831; rs11234706; rs10559079; rs4471455; rs34334006; rs1060779; rs35625263; rs503949; rs28865371; rs28850038; rs11234667; rs4614483; rs36030892; rs36014844; rs747227; rs11388635; rs28605742; rs35377581; rs7115713; rs619472; rs7124121; rs36012184; rs35255565; rs34698065; rs35650693; rs11234672; rs12805421; rs620054; rs11518768; rs11824279; rs11442101; rs35831878; rs35439198; rs28824521; rs35676005; rs11234730; rs4553393; rs12280255; rs11518770; rs648726; rs5793200; rs5793207; rs12804407; rs35754183; rs34677719; rs34493285; rs619829; rs11234671; rs11501724; rs883190; rs688119; rs648258; rs663627; rs12417361; rs11234717; rs7484000; rs11234688; rs12272130; rs28803287; rs35723009; rs35942916; rs3216158; rs12805438; rs35042210; rs7111906; rs11537258; rs2511080; rs10539253; rs35030247; rs11501841; rs4291697; rs35061999; rs5793199; rs603890; rs1612079; rs35686713; rs35722020; rs35636838; rs12805566; rs10160338; rs11234684; rs35072041; rs34920485; rs2125361; rs11234698; rs1938937; rs509870; rs35086246; rs34385651; rs34267395; rs11305226; rs34371898; rs637758; rs5793203; rs550168; rs11494275; rs34952173; rs11402713; rs561237; rs11234703; rs36107930; rs35726265; rs34433932; rs613418; rs12792072; rs35180248; rs10751139; rs12222272; rs655868; rs34237389; rs34730962; rs34249558; rs12098937; rs36078024; rs35193618; rs10583492; rs35420443; rs34837662; rs34902539; rs11234652; rs11607319; rs11828146; rs12270761; rs12276248; rs12293159; rs1452133; rs1938936; rs2034622; rs2051435; rs2051436; rs2051437; rs2051438; rs3741004; rs4393345; rs516066; rs516746; rs567615; rs571006; rs594361; rs615858; rs642245; rs643157; rs674053; rs693817

# Metabolic_Enzyme_9_General_References:
7818469

# Metabolic_Enzyme_9_References:
10940008

# Macromolecular_Interacting_Partner_1_ID:
7549

# Macromolecular_Interacting_Partner_1_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
INS

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_1_Signals:
1-24

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
INS

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11p15.5

# Macromolecular_Interacting_Partner_1_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_1_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_1_References:
15986240

# Macromolecular_Interacting_Partner_2_ID:
8369

# Macromolecular_Interacting_Partner_2_Name:
Oxidoreductase

# Macromolecular_Interacting_Partner_2_Synonyms:
Hydroxysteroid; 17-betadehydrogenase 6; 3- hydroxysteroid epimerase

# Macromolecular_Interacting_Partner_2_Gene_Name:
HSD17B6

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Oxidoreductase
MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC
LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT
LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK
YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ
QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS
LADYILTRSWPKPAQAV

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
317

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
35966

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
8.91

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Lipid transport and metabolism 

# Macromolecular_Interacting_Partner_2_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00106:adh_short

# Macromolecular_Interacting_Partner_2_Signals:
1-25

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
2338748

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
O14756_HUMAN (O14756)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
HSD17B6

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
HSD17B6

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:23316

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>954 bp
ATGTGGCTCTACCTGGCAGCCTTCGTGGGCCTGTACTACCTTCTGCACTGGTACCGGGAG
AGGCAGGTGGTGAGCCACCTCCAAGACAAGTATGTCTTTATCACGGGCTGTGACTCGGGC
TTTGGGAACCTACTGGCCAGACAGCTGGATGCACGAGGCTTGAGAGTGCTGGCTGCGTGT
CTGACGGAGAAGGGGGCCGAGCAGCTGAGGGGCCAGACGTCTGACAGGCTGGAGACGGTG
ACCCTGGATGTTACCAAGATGGAGAGCATCGCTGCAGCTACTCAGTGGGTGAAGGAGCAT
GTGGGGGACAGAGGACTCTGGGGACTGGTGAACAATGCAGGCATTCTTACACCAATTACC
TTATGTGAGTGGCTGAACACTGAGGACTCTATGAATATGCTCAAAGTGAACCTCATTGGT
GTGATCCAGGTGACCTTGAGCATGCTTCCTTTGGTGAGGAGAGCACGGGGAAGAATTGTC
AATGTCTCCAGCATTCTGGGAAGAGTTGCTTTCTTTGTAGGAGGCTACTGTGTCTCCAAG
TATGGAGTGGAAGCCTTTTCAGATATTCTGAGGCGTGAGATTCAACATTTTGGGGTGAAA
ATCAGCATAGTTGAACCTGGCTACTTCAGAACGGGAATGACAAACATGACACAGTCCTTA
GAGCGAATGAAGCAAAGTTGGAAAGAAGCCCCCAAGCATATTAAGGAGACCTATGGACAG
CAGTATTTTGATGCCCTTTACAATATCATGAAGGAAGGGCTGTTGAATTGTAGCACAAAC
CTGAACCTGGTCACTGACTGCATGGAACATGCTCTGACATCGGTGCATCCGCGAACTCGA
TATTCAGCTGGCTGGGATGCTAAATTTTTCTTCATCCCTCTATCTTATTTACCTACATCA
CTGGCAGACTACATTTTGACTAGATCTTGGCCCAAACCAGCCCAGGCAGTCTAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AF016509

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_2_Locus:
12q13

# Macromolecular_Interacting_Partner_2_SNPs:
rs898611; rs7967600; rs7980317; rs11835916; rs12229709; rs12227131; rs12809466; rs12227117; rs7295862; rs10876921; rs10459247; rs10459246; rs10876920; rs11830415; rs4277148; rs2371628; rs12229899; rs10747770; rs11832786; rs10876919; rs4759256; rs35174136; rs35329345; rs10538536; rs5798394; rs12366563; rs35348347; rs34561077; rs34270146; rs5798395; rs11171967; rs35753038; rs12828479; rs35374137; rs34769799; rs11171966; rs12229409; rs34937784; rs35897287; rs34249257; rs12317442; rs10876922; rs34522994; rs11171968; rs11171969; rs28564526; rs3816616; rs35988358; rs34194340; rs12300153; rs34050360; rs34383378; rs11407460; rs12826939; rs11835254; rs35582861; rs12827132; rs4578426; rs6581104; rs7313074

# Macromolecular_Interacting_Partner_2_General_References:
9188497; 11360992; 12477932; 10896656

# Macromolecular_Interacting_Partner_2_References:
8706750

# Macromolecular_Interacting_Partner_3_ID:
8212

# Macromolecular_Interacting_Partner_3_Name:
LIM domain-binding protein 3

# Macromolecular_Interacting_Partner_3_Synonyms:
Z-band alternatively spliced PDZ-motif protein; Protein cypher

# Macromolecular_Interacting_Partner_3_Gene_Name:
LDB3

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>LIM domainbinding protein 3
MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM
THLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAP
SPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDL
LGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPIKDLAVD
SASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSST
PIEHAPVCTSQATTPLLPASAQPPAAASPSAASPPLATAAAHTAIASASTTAPASSPADS
PRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSP
GANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGG
PAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAE
RFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCER
CYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKD
YINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKK
HAHTINL

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
727

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
77135

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
8.20

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  protein binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Transcription 

# Macromolecular_Interacting_Partner_3_Specific_Function:
May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00412:LIM;
PF00595:PDZ

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
5441367

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
LDB3_HUMAN (O75112)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
LDB3

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
LDB3

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:15710

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cytoplasm; perinuclear region. Cell projection; pseudopodium. Note=Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>852 bp
ATGTCTTACAGTGTGACCCTGACTGGGCCCGGGCCCTGGGGCTTCCGTCTGCAGGGGGGC
AAGGACTTCAACATGCCCCTCACTATCTCCCGGATCACACCAGGCAGCAAGGCAGCCCAG
TCCCAGCTCAGCCAGGGTGACCTCGTGGTGGCCATTGACGGCGTCAACACAGACACCATG
ACCCACCTGGAAGCCCAGAACAAGATCAAGTCTGCCAGCTACAACTTGAGCCTCACCCTG
CAGAAATCAAAGCGTCCCATTCCCATCTCCACGACAGCACCTCCAGTCCAGACCCCTCTG
CCGGTGATCCCTCACCAGAAGGTGGTAGTCAACTCTCCAGCCAACGCCGACTACCAGGAA
CGCTTCAACCCCAGTGCCCTGAAGGACTCGGCCCTGTCCACCCACAAGCCCATCGAGGTG
AAGGGGCTGGGCGGCAAGGCCACCATCATCCATGCGCAGTACAACACGCCCATCAGCATG
TATTCCCAGGATGCCATCATGGATGCCATCGCTGGGCAGGCCCAAGCCCAAGGCAGTGAC
TTCAGTGGGAGCCTCCCTATTAAGGACCTTGCCGTAGACAGCGCCTCTCCCGTCTACCAG
GCTGTGATTAAGAGCCAGAACAAGCCAGAAGATGAGGCTGACGAGTGGGCACGCCGTTCC
TCCAACCTGCAGTCTCGCTCCTTCCGCATCCTGGCCCAGATGACGGGGACAGAATTCATG
CAAGACCCTGATGAAGAAGCTCTGCGAAGTCAAGGGAAAGGTTTGAAACGGAAACGTAAC
AGCCCACGTTTTGCCAAATTGCGCAACTGGCACCATGGCCTTTCAGCCCAAATCCTTAAT
GTTAAAAGCTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AJ133766

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_3_Locus:
10q22.3-q23.2

# Macromolecular_Interacting_Partner_3_SNPs:
rs3740343; rs34218952; rs3802664; rs4468255; rs11202124; rs2803560; rs7086308; rs3740342; rs7092188; rs4934245; rs4934254; rs7916248; rs6586024; rs2248643; rs6586023; rs4934244; rs7908765; rs7085298; rs4934251; rs2803566; rs2803567; rs1578895; rs3802663; rs6586031; rs7069570; rs4462249; rs11593608; rs10788526; rs2675686; rs3802662; rs4408238; rs6586029; rs2354360; rs11202121; rs2803570; rs4934246; rs10887650; rs6586032; rs4556455; rs4278432; rs12244569; rs4525132; rs6586025; rs17335189; rs3740347; rs7899337; rs10887639; rs2354363; rs4620630; rs7899324; rs2675691; rs3740346; rs3740345; rs2248537; rs4933405; rs2247689; rs11812963; rs11202117; rs10788525; rs2248538; rs7099341; rs12569813; rs4934253; rs11599515; rs1986382; rs11594919; rs2803572; rs7894381; rs11202120; rs2803562; rs10788524; rs12244574; rs1986383; rs6586026; rs11595553; rs2675700; rs2354359; rs12251784; rs11202140; rs2354357; rs12260726; rs7086122; rs7895178; rs1806471; rs17426050; rs11819261; rs11202119; rs11202136; rs12221151; rs11202133; rs7475311; rs12414766; rs10887646; rs2803559; rs4934250; rs10887645; rs2803561; rs17106968; rs7908829; rs17106978; rs12263789; rs12258339; rs11202122; rs7088948; rs10887641; rs12240576; rs4492716; rs7075204; rs4933406; rs11202118; rs11814947; rs11597201; rs2354356; rs2244769; rs10887644; rs7893160; rs12251655; rs12570315; rs7923558; rs10749541; rs7074015; rs10887651; rs12254069; rs12770250; rs10788522; rs17335168; rs10887643; rs7918367; rs4934249; rs2803568; rs4934252; rs11202126; rs12220664; rs17106959; rs12570147; rs12268509; rs2803571; rs11202138; rs10887648; rs10788523; rs17106956; rs7909928; rs2803564; rs11202128; rs2354362; rs4934248; rs2354358; rs3740344; rs11592193; rs4933404; rs12251540; rs11202127; rs2354361; rs10887642; rs7079363; rs2803563; rs12265236; rs12414832; rs4934243; rs10887640; rs17106945; rs35569375; rs17426017; rs7910307; rs10887647; rs11815273; rs12415298; rs7908743; rs4256897; rs2675692; rs2675693; rs2803555; rs2803558; rs34499525; rs35777670; rs11812601; rs34959905; rs34073498; rs34346910; rs35507268; rs12761754; rs34423165; rs12761767; rs11277810; rs35222021; rs1129720; rs1140171; rs34120124; rs35309921; rs11295601; rs12771857; rs7476499; rs41306868; rs7090715; rs35869109; rs3740348; rs34836333; rs12241060; rs12251973; rs34158661; rs34407382; rs9325589; rs12267313; rs11202132; rs11312118; rs7476032; rs7067613; rs36034038; rs34555032; rs41284059; rs11816975; rs4934247; rs34886010; rs35422936; rs12218053; rs12218046; rs11596380; rs35348533; rs10636675; rs12777922; rs34393529; rs3086887; rs11202134; rs7897549; rs11294968; rs36008448; rs11394900; rs36082932; rs10573832; rs34552947; rs35644119; rs3204237; rs12359981; rs4933407; rs34677208; rs4611110; rs36037775; rs5786744; rs10600377; rs35075932; rs3204236; rs34609974; rs35443941; rs7350396; rs11202137; rs12771609; rs12217487; rs35496319; rs12570979; rs11331035; rs2675690; rs5786743; rs11202130; rs11813013; rs4934242; rs34215720; rs12773201; rs34010340; rs9794160; rs36035051; rs12220648; rs35038512; rs35036282; rs7080273; rs35548503; rs11422538; rs6586027; rs34941291; rs7901128; rs36003521; rs12243535; rs12219069; rs35158654; rs35076035; rs7907134; rs36086893; rs12240646; rs11202139; rs34544606; rs35171755; rs12219020; rs4934241; rs11202131; rs12248422; rs34295502; rs35394356; rs12262050; rs12259201; rs35543964; rs12251776; rs35305714; rs1140170; rs11594242; rs34647099; rs10664257; rs1962096; rs11271876; rs10562903; rs36202103; rs11202135; rs11202129; rs11306108; rs35605324; rs12773445; rs12220339; rs12773033; rs7921989; rs7088351; rs4934240; rs2803557; rs34339902; rs2803556; rs35593937; rs34972863; rs34432919; rs11314847; rs36073042; rs35584371; rs1079610; rs11202110; rs11202111; rs11202113; rs11202142; rs1125774; rs11594957; rs12220083; rs12244985; rs12252834; rs12261055; rs12262894; rs12763142; rs17425122; rs17425484; rs2014077; rs2014084; rs2254548; rs2675694; rs2675695; rs2675696; rs2675697; rs2675698; rs2736687; rs2803550; rs2803551; rs2803553; rs2803554; rs33921909; rs33936589; rs34088875; rs35264027; rs35357978; rs36064638; rs3740332; rs3740335; rs3740337; rs3740340; rs3740341; rs3924093; rs4244972; rs4394749; rs4934255; rs4934256; rs7069417; rs7086492; rs7478092; rs7911340; rs7917572; rs909285

# Macromolecular_Interacting_Partner_3_General_References:
10427098; 9734811; 11842093

# Macromolecular_Interacting_Partner_3_References:
15319808

End of HMDB00134

Beginning of HMDB00138
# Accession_No:
HMDB00138

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-07-17 13:58:36

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Glycocholic acid

# Description:
Glycocholic acid or cholylglycine, is a crystalline bile acid involved in the emulsification of fats. It occurs as a sodium salt in the bile of mammals. Its anion is called glycocholate. (wikipedia) The glycine conjugate of CHOLIC ACID. It acts as a detergent to solubilize fats for absorption and is itself absorbed. (PubChem)
A bile acid. Bile acids are steroid acids found predominantly in bile of mammals. The distinction between different bile acids is minute, depends only on presence or absence of hydroxyl groups on positions 3, 7, and 12. 
Bile acids are physiological detergents that facilitate excretion, absorption, and transport of fats and sterols in the intestine and liver. Bile acids are also steroidal amphipathic molecules derived from the catabolism of cholesterol. They modulate bile flow and lipid secretion, are essential for the absorption of dietary fats and vitamins, and have been implicated in the regulation of all the key enzymes involved in cholesterol homeostasis. 
Bile acids recirculate through the liver, bile ducts, small intestine and portal vein to form an enterohepatic circuit. They exist as anions at physiological pH and, consequently, require a carrier for transport across the membranes of the enterohepatic tissues. The unique detergent properties of bile acids are essential for the digestion and intestinal absorption of hydrophobic nutrients. Bile acids have potent toxic properties (e.g., membrane disruption) and there are a plethora of mechanisms to limit their accumulation in blood and tissues. (PMID: 11316487, 16037564, 12576301, 11907135)


# Synonyms:
3a,7a,12a-Trihydroxy-5b-cholan-24-oylglycine; 3a,7a,12a-Trihydroxy-5b-cholanic acid-24-glycine; 3a,7a,12a-Trihydroxy-N-(carboxymethyl)-5b-cholan-24-amide; Cholylglycine; Glycine cholate; Glycocholate; Glycocholic acid; Glycoreductodehydrocholic acid; Glycylcholate; Glycylcholic acid; N-(carboxymethyl)-3a,7a,12a-trihydroxy-5b-Cholan-24-amide; N-Choloylglycine; N-choloyl-Glycine

# Chemical_IUPAC_Name:
2-[4-(3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoylamino]acetic acid

# Chemical_Formula:
C26H43NO6

# Chemical_Structure:
tbl_chemical:::HMDB00138_ZOOM.png:::119283212236259595

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00138_THUMB.png:::119283212031922381

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Steroids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
secondary alcohol; carboxylic acid; secondary carboxylic acid amide

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
465.30905

# Molecular_Weight_Avg:
465.62274

# Smiles_String_isomeric:
C[C@H](CCC(=O)NCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)CC4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

# Smiles_String_canonical:
CC(CCC(=O)NCC(O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C

# KEGG_Compound_ID:
C01921

# BioCyc_ID:
GLYCOCHOLIC_ACID

# PubChem_CID:
439604

# PubChem_SID:
5027; 8145498

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
38691

# Wikipedia_ID:
Glycocholic acid

# METLIN_ID:
5169

# Ref_ID:
3816078; 7119120; 7261553; 12487922; 12883481; 1447600; 6648236; 16241870; 3966491; 16629939; 7274980; 2108486; 1460824; 12456554; 6669944; 832799; 2796646; 8500713; 3944741

# ChEBI_ID:
29746

# CAS_Registry_Number:
475-31-0

# InChI:
InChI=1/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/t14-,15?,16-,17-,18+,19+,20?,21+,24+,25+,26-/m1/s1

# Synthesis_Reference:
Synthesis of conjugated bile acids. IV. The Bondi and Mueller procedure.     Cortese, Frank.    Journal of the American Chemical Society  (1937),  59  2532-4.

# Melting_Point:
170 oC

# Melting_Point_predicted:
156.7 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.0033 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
0.0248 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
1.65 [RODA,A ET AL. (1990)]

# LogP_predicted:
1.70 [Predicted by ALOGPS]; 1.1 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Glycocholic acid hydrate.pdf:::1132562205006254552

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Glycocholic_acid.mol:::1132723809156338974

# SDF_File_[Text]:
tbl_chemical:::HMDB00138.sdf:::119283211342943842

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00138.pdb:::119283211893755618

# PDB_ID:
1EIO

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041026_P00_03_HW_1DP_presat.png:::114866713449895229

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041026_P00_03_HW_1DP_presat.zip:::114866742362657330

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041026_P00_03_HW_2DHSQC_909.png:::114807748412815245

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041026_P00_03_HW_2DHSQC_909.zip:::114807748413386150

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041026_P00_03_HW_2DHSQC_909_Assigned.png:::11628327020473845

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Glycocholic acid.gif:::1132732112953581534

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00138_peaks.txt:::1156309569990462583

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Glycocholic acid_C.gif:::1132737696643964413

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00138_peaks.txt:::1156310759903508142

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00138L.png:::117555262416498326; Medium Energy:tbl_ms:::HMDB00138M.png:::11755526779481299; High Energy:tbl_ms:::HMDB00138H.png:::117555271411212921

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; Extracellular; peroxisome

# Tissue_Location:
Fibroblasts; Liver

# deuterated:
No

# Biofluid_Location:
Bile; Blood; Urine

# Concentration_[Normal]:
Urine	0.42 +/- 0.36	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	3944741
Blood	0.71	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	0.06 +/- 0.04	uM	Adult:>18_yrs_old	Both	Normal	3816078
Blood	0.1-1.4	umol/L	Children:1-13_yrs_old	Both	Normal	7119120


# Concentration_[Abnormal]:
Urine	1.55 +/- 1.22	umol/mmol_creatinine	Adult:>18_yrs_old	Both		3944741
Blood	0.7 +/- 0.13	uM	Adult:>18_yrs_old	Both	Coeliac Disease	3816078
Blood	43.6 +/- 11.8	uM	Adult:>18_yrs_old	Both	Hepatobiliary Disease	16629939


# Associated_Disorders:
Alcoholic Liver Disease; Coeliac Disease; Crohn's Disease; Hepatobiliary Disease

# Pathway_Names:
Purine metabolism;Nicotinate and nicotinamide metabolism

# Pathway_Images:
Purine_Synthesis.jpg;Nicotinamide_synthesis_(NADH).jpg

# KEGG_Images:
map00230;map00760

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;Nicotinamide_synthesis_(NADH)_Graph.jpg

# Pathway_SBMLs:
Purine_Synthesis.xml;Nicotinamide_synthesis_(NADH).xml

# Metabolic_Enzyme_1_ID:
5236

# Metabolic_Enzyme_1_Name:
5'(3')-deoxyribonucleotidase, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
5',3'-nucleotidase, mitochondrial; Deoxy-5'-nucleotidase 2; dNT-2

# Metabolic_Enzyme_1_Gene_Name:
NT5M

# Metabolic_Enzyme_1_Protein_Sequence:
>5'3'deoxyribonucleotidase, mitochondrial precursor
MIRLGGWCARRLCSAAVPAGRRGAAGGLGLAGGRALRVLVDMDGVLADFEGGFLRKFRAR
FPDQPFIALEDRRGFWVSEQYGRLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMAS
LQNTDVFICTSPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDI
TGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRPC

# Metabolic_Enzyme_1_Number_of_Residues:
228

# Metabolic_Enzyme_1_Molecular_Weight:
25862

# Metabolic_Enzyme_1_Theoretical_pI:
8.12

# Metabolic_Enzyme_1_GO_Classification:
Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP

# Metabolic_Enzyme_1_Pathway:
Not Available

# Metabolic_Enzyme_1_Reaction:
Not Available

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_1_Signals:
1-15

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
9408106

# Metabolic_Enzyme_1_SwissProt_ID:
NT5M_HUMAN (Q9NPB1)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
NT5M

# Metabolic_Enzyme_1_Geneatlas_id:
NT5M

# Metabolic_Enzyme_1_hgnc_id:
HGNC:15769

# Metabolic_Enzyme_1_PDB_ID:
1Q92

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_1_Gene_Sequence:
>687 bp
ATGATCCGGCTGGGCGGCTGGTGTGCGCGGCGGCTCTGCAGCGCGGCGGTTCCCGCGGGG
CGGCGCGGGGCGGCGGGCGGGCTGGGCCTGGCGGGAGGCCGCGCCCTACGGGTGCTGGTG
GACATGGACGGCGTGCTGGCTGACTTCGAGGGCGGATTCCTCAGGAAGTTCCGCGCGCGC
TTTCCCGACCAGCCCTTCATCGCGCTGGAGGACCGGCGCGGCTTCTGGGTGTCGGAGCAG
TACGGCCGCCTGCGGCCAGGGCTGAGCGAGAAGGCCATCAGCATTTGGGAGTCAAAGAAT
TTCTTTTTTGAACTTGAGCCTCTGCCAGGGGCCGTGGAAGCTGTCAAGGAGATGGCCAGC
CTACAAAACACTGACGTCTTCATCTGCACAAGCCCCATCAAGATGTTCAAGTACTGTCCC
TATGAGAAGTATGCCTGGGTGGAGAAGTACTTTGGCCCTGACTTTCTGGAGCAGATTGTG
CTGACCAGAGACAAGACCGTGGTCTCTGCTGACCTTCTCATAGACGACCGGCCGGACATC
ACAGGGGCCGAGCCAACCCCCAGCTGGGAGCATGTCCTCTTCACCGCCTGCCACAACCAG
CACCTGCAGCTGCAGCCCCCCCGCCGCAGGCTGCACTCGTGGGCGGACGACTGGAAGGCC
ATTCTGGACAGCAAGCGGCCCTGCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AJ277557

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_1_Locus:
17p11.2

# Metabolic_Enzyme_1_SNPs:
rs2240876; rs758742; rs1860553; rs242243; rs6502579; rs7223473; rs11078384; rs7226068; rs10468464; rs12948296; rs1860552; rs9912109; rs9898622; rs7211968; rs17726703; rs9914692; rs3785502; rs11867932; rs3785504; rs17726673; rs11654778; rs16942153; rs17726858; rs11078382; rs3826302; rs2064060; rs6502580; rs7217503; rs9912172; rs3785506; rs9908168; rs11652902; rs9902505; rs4985707; rs6502576; rs6502578; rs16961564; rs7210344; rs16961516; rs242242; rs171394; rs12600778; rs9909111; rs7219752; rs6502577; rs12601631; rs11869054; rs17726924; rs9891799; rs11870836; rs11869507; rs11078383; rs4985706; rs7217162; rs9889738; rs9908338; rs7222555; rs9915883; rs7211243; rs9916133; rs9907857; rs9905836; rs11657817; rs9889298; rs7220829; rs9903425; rs9908360; rs9914424; rs9908124; rs11650700; rs11869079; rs7212369; rs9889367; rs7217114; rs9896977; rs9916676; rs16961561; rs12602026; rs9896970; rs9904396; rs9909850; rs10852849; rs11078385; rs6502575; rs242244; rs16961576; rs3203918; rs8082383; rs7212012; rs36114962; rs9889834; rs7226045; rs12602003; rs9894669; rs35712658; rs12941075; rs7210625; rs35320589; rs11655849; rs35470335; rs34668117; rs12943271; rs34446504; rs35945070; rs34219219; rs12951176; rs35554631; rs34408375; rs28825184; rs7218566; rs35917484; rs28880443; rs9904393; rs12601106; rs34579357; rs4985765; rs9907711; rs11343472; rs35579933; rs3087093; rs12951985; rs34993127; rs36088408; rs36091965; rs34100977; rs7220057; rs8080335; rs9901325; rs35720826; rs34886391; rs12949216; rs9898993; rs34121330; rs34513135; rs12936127; rs8067236; rs8081939; rs10617184; rs7211790; rs9914209; rs12951519; rs12603230; rs9913775; rs8068408; rs12452455; rs9901373; rs3063349; rs9913682; rs3785503; rs34156759; rs34776810; rs10574223; rs34836173; rs12951434; rs9709057; rs28813401; rs36146846; rs34709982; rs28616155; rs8082379; rs35267848; rs12951289; rs12948357; rs12950577; rs35861887; rs12948747; rs35096596; rs8080408; rs9898042; rs35930947; rs12948751; rs5741757; rs9889355; rs35575792; rs34018072; rs34407368; rs4985764; rs11395505; rs34676851; rs12951504; rs12950929; rs34025151; rs3837806; rs34247865; rs12946386; rs34209605; rs7219953; rs12951983; rs11400183; rs9912599; rs36056059; rs8071972; rs35039203; rs35326975; rs8071718; rs12946113; rs1009720; rs10852850; rs11078381; rs11078386; rs11871699; rs12450758; rs12451886; rs12452946; rs12602578; rs16961593; rs16961599; rs17648393; rs183596; rs190261; rs2041393; rs2058292; rs2191383; rs242246; rs242247; rs242249; rs242250; rs242251; rs624242; rs6502572; rs8067390; rs9892592; rs9899615; rs9905458; rs9909800; rs9914113

# Metabolic_Enzyme_1_General_References:
10899995; 12352955

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5237

# Metabolic_Enzyme_2_Name:
Cytosolic purine 5'-nucleotidase

# Metabolic_Enzyme_2_Synonyms:
5'-nucleotidase cytosolic II

# Metabolic_Enzyme_2_Gene_Name:
NT5C2

# Metabolic_Enzyme_2_Protein_Sequence:
>Cytosolic purine 5'nucleotidase
MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVY
KSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLV
CAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTS
CETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMK
EVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGT
VLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKS
KKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQ
RRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAA
HVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLA
PQEITHCHDEDDDEEEEEEEE

# Metabolic_Enzyme_2_Number_of_Residues:
561

# Metabolic_Enzyme_2_Molecular_Weight:
64970

# Metabolic_Enzyme_2_Theoretical_pI:
6.05

# Metabolic_Enzyme_2_GO_Classification:
Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides

# Metabolic_Enzyme_2_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_2_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF05761:5_nucleotid

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
633071

# Metabolic_Enzyme_2_SwissProt_ID:
5NTC_HUMAN (P49902)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
NT5C2

# Metabolic_Enzyme_2_Geneatlas_id:
NT5C2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:8022

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1686 bp
ATGTCGACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGAT
AAGCATGCCCTGAAAAAGTATCGTCGAGAAGCCTATCATCGGGTGTTTGTGAACCGAAGT
TTAGCAATGGAAAAGATAAAGTGTTTTGGTTTTGATATGGATTATACCCTTGCTGTGTAC
AAGTCCCCAGAGTATGAGTCCCTTGGTTTTGAGCTTACTGTGGAGAGATTAGTTTCTATT
GGCTATCCCCAGGAGTTGCTCAGCTTTGCTTATGATTCTACATTCCCTACCAGGGGACTT
GTCTTTGACACACTGTATGGAAATCTTTTGAAAGTCGATGCCTATGGAAACCTCTTGGTC
TGTGCACATGGATTTAACTTTATAAGGGGACCAGAAACTAGAGAACAGTATCCAAATAAA
TTTATCCAGCGAGATGATACTGAAAGATTTTACATTCTGAACACACTATTCAACCTACCA
GAGACCTACCTGTTGGCCTGCCTAGTAGATTTTTTTACTAATTGTCCCAGATATACCAGT
TGTGAAACAGGATTTAAAGATGGGGACCTCTTCATGTCCTACCGGAGTATGTTCCAGGAT
GTAAGAGATGCTGTTGACTGGGTTCATTACAAGGGCTCCCTTAAGGAAAAGACAGTTGAA
AATCTTGAGAAGTATGTAGTCAAAGATGGAAAACTGCCTTTGCTTCTGAGCCGGATGAAG
GAAGTAGGGAAAGTATTTCTTGCTACCAACAGTGACTATAAATATACAGATAAAATTATG
ACTTACCTGTTTGACTTCCCACATGGCCCCAAGCCTGGGAGCTCCCATCGACCATGGCAG
TCCTACTTTGACTTGATCTTGGTGGATGCACGGAAACCACTCTTTTTTGGAGAAGGCACA
GTACTGCGTCAGGTGGATACTAAAACTGGCAAGCTGAAAATTGGTACCTACACAGGGCCC
CTACAGCATGGTATCGTCTACTCAGGAGGTTCTTCTGATACGATCTGTGACCTGTTGGGA
GCCAAGGGAAAAGACATTTTGTATATTGGAGATCACATTTTTGGGGACATTTTAAAATCA
AAGAAACGGCAAGGGTGGCGAACTTTTTTGGTGATTCCTGAACTCGCACAGGAGCTACAT
GTCTGGACTGACAAGAGTTCACTTTTCGAAGAACTTCAGAGCTTGGATATTTTCTTGGCT
GAACTCTACAAGCATCTTGACAGCAGTAGCAATGAGCGTCCAGACATCAGTTCCATCCAG
AGACGTATTAAGAAAGTAACTCATGACATGGACATGTGCTATGGGATGATGGGAAGCCTG
TTTCGCAGTGGCTCCCGGCAGACCCTTTTTGCCAGTCAAGTGATGCGTTATGCTGACCTC
TATGCAGCATCTTTCATCAACCTGCTGTATTACCCTTTCAGCTACCTCTTCAGGGCTGCC
CATGTCTTGATGCCTCATGAATCAACGGTGGAGCACACACACGTAGATATCAATGAGATG
GAGTCTCCTCTTGCCACCCGGAACCGCACATCAGTGGATTTCAAAGACACTGACTACAAG
CGGCACCAGCTGACACGGTCAATTAGTGAGATTAAACCTCCCAACCTCTTCCCACTGGCC
CCCCAGGAAATTACACACTGCCATGACGAAGATGATGATGAAGAGGAGGAGGAGGAGGAA
GAATAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
D38524

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_2_Locus:
10q24.32-q24.33

# Metabolic_Enzyme_2_SNPs:
rs12262171; rs3740387; rs12253627; rs10786736; rs8139; rs7917650; rs10786741; rs7920251; rs10430665; rs7916854; rs12573199; rs11191598; rs1163238; rs12573200; rs10883843; rs7092407; rs12573221; rs4917997; rs11191593; rs11191596; rs10786744; rs1163236; rs10883842; rs10786742; rs10786743; rs7075552; rs7077097; rs2863728; rs3758543; rs7077291; rs10748838; rs3087681; rs12240508; rs732998; rs10883830; rs7899084; rs2274340; rs2182348; rs2066322; rs7908960; rs7912517; rs7067970; rs3740386; rs7896547; rs11191554; rs1163249; rs2281877; rs2863727; rs3781281; rs2274341; rs2148198; rs7897663; rs3781282; rs10883832; rs1926029; rs1935323; rs1926030; rs746293; rs6584539; rs2066323; rs9919482; rs3740385; rs12773916; rs12414232; rs10786737; rs12413046; rs12412038; rs2274339; rs11598702; rs1541213; rs11191580; rs11191553; rs10509765; rs10509766; rs3977751; rs12220375; rs4917996; rs7896433; rs6584540; rs1926037; rs3736922; rs11191577; rs2148197; rs11191561; rs7080935; rs11191555; rs10883833; rs12219304; rs1926036; rs7913920; rs10883834; rs11191558; rs11191582; rs11191589; rs10883831; rs12220743; rs10786738; rs11191560; rs10748837; rs11191578; rs3781280; rs7896519; rs12217501; rs11191573; rs7067741; rs6584541; rs7067663; rs2148200; rs10883840; rs11191583; rs12415199; rs9919485; rs11191557; rs17094683; rs7895154; rs12355120; rs2153774; rs10786739; rs7915816; rs7081075; rs1807298; rs3861984; rs11191572; rs12571568; rs12416331; rs11191586; rs10883839; rs12766205; rs1163239; rs10883837; rs11191584; rs1163247; rs17115452; rs11191556; rs7909022; rs12775302; rs9633712; rs11191581; rs11191576; rs10883836; rs11191549; rs7095304; rs10883845; rs11191550; rs11191548; rs11191602; rs10748839; rs1141101; rs1055812; rs1141100; rs1141098; rs1141099; rs34351688; rs34394526; rs34058246; rs11191594; rs35224704; rs34747231; rs12774207; rs11191595; rs34699185; rs11280184; rs1163237; rs7073259; rs34064597; rs11191601; rs35525740; rs35291480; rs12264098; rs35978588; rs12241986; rs7091462; rs12774182; rs34756486; rs35695488; rs12252236; rs3834416; rs11191600; rs34136949; rs7080242; rs12763243; rs34003851; rs11191585; rs11191551; rs36111455; rs34966121; rs35464534; rs35541240; rs11191571; rs35913488; rs34223002; rs11440429; rs41287482; rs35653865; rs34963818; rs11191559; rs11191568; rs35436872; rs17795366; rs1163246; rs34060908; rs34963563; rs34915846; rs12780509; rs2153773; rs34211645; rs3736924; rs34758128; rs36059537; rs35302704; rs12255989; rs34104646; rs11191574; rs11191564; rs35745742; rs34644789; rs5787481; rs34863357; rs11191590; rs12774840; rs2148196; rs12763944; rs3215816; rs34207290; rs35752695; rs34445719; rs28419708; rs4421684; rs28516969; rs12265498; rs12767422; rs12772228; rs34908445; rs11191570; rs17115449; rs35195396; rs12243923; rs10883835; rs12779263; rs11302933; rs7091173; rs11375439; rs7071103; rs35146429; rs35338839; rs34268365; rs34130454; rs35898850; rs3861983; rs28404041; rs35621207; rs3736923; rs5787482; rs7075048; rs34307431; rs35348020; rs34349473; rs1773930; rs11191566; rs34870452; rs35078544; rs35123178; rs12265545; rs1163241; rs3949893; rs7904067; rs12775841; rs35821867; rs12775904; rs7915032; rs5028036; rs35254502; rs1163248; rs35365027; rs34876862; rs11191565; rs12772280; rs10709724; rs35085852; rs35351555; rs12774513; rs10710371; rs11296588; rs12243903; rs28605898; rs34241930; rs34549427; rs11451961; rs34403968; rs12761657; rs34397864; rs3062737; rs36092020; rs35109679; rs34011916; rs34435560; rs11191562; rs4917383; rs34067380; rs34202831; rs11191563; rs2148199; rs34133379; rs35763505; rs12414385; rs1163240; rs12262258; rs11191588; rs34664715; rs12414374; rs35133717; rs3837340; rs10614009; rs2153772; rs11191587; rs11403586; rs11191575; rs1060240; rs34588165; rs11191552; rs41317254; rs1163245; rs1064099; rs12268552; rs34833988; rs11191603; rs12253716; rs12412924; rs3841710; rs34551510; rs12246784; rs12781668; rs1064098; rs10458729; rs10786740; rs10786745; rs10883829; rs10883841; rs11191547; rs1163235; rs12261294; rs12571345; rs12785223; rs17115427; rs4307650; rs4917382; rs4917995; rs7074395; rs7092200; rs726010; rs763914; rs7921996; rs943035

# Metabolic_Enzyme_2_General_References:
7999131

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5232

# Metabolic_Enzyme_3_Name:
Cytosolic 5'-nucleotidase 1B

# Metabolic_Enzyme_3_Synonyms:
Cytosolic 5'-nucleotidase IB; cN1B; cN-IB; Autoimmune infertility-related protein

# Metabolic_Enzyme_3_Gene_Name:
NT5C1B

# Metabolic_Enzyme_3_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
BMSQTSLKQKKNEPGMRSSKESLEAEKRKESDKTGVRLSNQMRRAVNPNHSLRCCPFQGH
SSCRRCLCAAEGTALGPCHTIRIYIHMCLLWEQGQQITMMRGSQESSLRKTDSRGYLVRS
QWSRISRSPSTKAPSIDEPRSRNTSAKLPSSSTSSRTPSTSPSLHDSSPPPLSGQPSLQP
PASPQLPRSLDSRPPTPPEPDPGSRRSTKMQENPEAWAQGIVREIRQTRDSQPLEYSRTS
PTEWKSSSQRRGIYPASTQLDRNSLSEQQQQQREDEDDYEAAYWASMRSFYEKNPSCSRP
WPPKPKNAITIALSSCALFNMVDGRKIYEQEGLEKYMEYQLTNENVILTPGPAFRFVKAL
QYVNARLRDLYPDEQDLFDIVLMTNNHAQVGVRLINSVNHYGLLIDRFCLTGGKDPIGYL
KAYLTNLYIAADSEKVQEAIQEGIASATMFDGAKDMAYCDTQLRVAFDGDAVLFSDESEH
FTKEHGLDKFFQYDTLCESKPLAQGPLKGFLEDLGRLQKKFYAKNERLLCPIRTYLVTAR
SAASSGARVLKTLRRWGLEIDEALFLAGAPKSPILVKIRPHIFFDDHMFHIEGAQRLGSI
AAYGFNKKFSS

# Metabolic_Enzyme_3_Number_of_Residues:
610

# Metabolic_Enzyme_3_Molecular_Weight:
68804

# Metabolic_Enzyme_3_Theoretical_pI:
9.03

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_3_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_3_GenBank_ID_Protein:
13774961

# Metabolic_Enzyme_3_SwissProt_ID:
5NT1B_HUMAN (Q96P26)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
NT5C1B

# Metabolic_Enzyme_3_Geneatlas_id:
NT5C1B

# Metabolic_Enzyme_3_hgnc_id:
HGNC:17818

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>1699 bp
GGGCAAAAATGTGGATAACAACAAAAGAATTTCAACAGGTAAAAAAATGAGTCAAACATC
TCTCAAACAGAAAAAGAATGAGCCCGGAATGAGGTCCTCAAAAGAGAGTCTAGAAGCAGA
AAAAAGAAAGGAATCTGACAAAACAGGAGTTCGTCTGAGCAATCAGGGATCACAAGAATC
ATCACTGCGGAAGACAGACTCTCGAGGGTACCTTGTGCGCAGTCAATGGTCTAGAATATC
CCGGAGCCCATCCACCAAGGCTCCATCCATAGATGAGCCTAGAAGCAGGAACACCAGTGC
TAAGCTCCCCAGCAGCTCCACGAGCTCCCGGACTCCATCCACCTCCCCAAGCCTGCATGA
CTCCTCACCGCCGCCGCTGTCCGGGCAGCCCTCGCTCCAGCCACCCGCGTCGCCCCAGCT
GCCCCGGTCGCTGGACTCGCGGCCTCCCACGCCCCCAGAGCCCGATCCTGGCTCCCGGCG
CAGCACCAAAATGCAAGAAAATCCGGAGGCCTGGGCCCAAGGCATCGTGCGGGAAATCCG
CCAGACCCGGGACTCGCAGCCGCTGGAATATTCGCGCACGTCCCCCACCGAGTGGAAGTC
CTCCAGCCAGCGCAGGGGGATCTACCCCGCCTCCACCCAGCTGGACCGCAACTCTCTGTC
CGAGCAGCAGCAGCAGCAGCGGGAGGACGAAGACGACTACGAAGCTGCCTACTGGGCATC
CATGAAGTCGTTCTACGAAAAGAACCCGAGCTGCTGGCGCCCCTGGCCGCCCAAACCCAA
GAACGCCATCACCATTGCTCTCTCATCCTGCGCGCTCTTCAACATGGTGGACGGCAGGAA
AATCTACGAGCAAGAGGGTCTGGAAAAGTACATGGAGTATCAGCTCACCAATGAGAACGT
CATCCTGACCCCGGGCCCGGCGTTCCGTTTCGTCAAGGCACTACAGTATGTCAATGCTAG
ACTCCGTGATCTATATCCTGATGAACAGGACTTATTTGATATTGTACTGATGACTAATAA
CCATGCCCAAGTGGGAGTGCGGCTTATAAACAGCGTCAATCACTACGGCTTACTGATTGA
CCGCTTCTGTCTGACCGGGGGAAAAGACCCCATTGGCTATTTGAAGGCATATCTTACCAA
CTTGTATATTGCTGCAGATTCTGAAAAAGTGCAAGAGGCAATACAAGAAGGTATTGCCTC
TGCGACAATGTTTGATGGAGCCAAAGACATGGCTTACTGTGACACTCAGCTCCGTGTAGC
CTTTGATGGGGATGCTGTCCTCTTCTCTGATGAGTCTGAACATTTTACCAAGGAGCATGG
GCTGGACAAATTCTTCCAGTATGATACATTATGTGAAAGTAAGCCTCTTGCTCAGGGTCC
CCTAAAAGGCTTTCTGGAAGATTTAGGCAGACTGCAAAAGAAGTTCTATGCCAAAAATGA
ACGGTTACTTTGTCCTATCAGGACCTACCTGGTTACAGCTAGGAGTGCAGCCAGTTCAGG
CGCCCGTGTGCTGAAAACCTTCCGACGCTGGGGTCTAGAGATAGACGAAGCTCTTTTCCT
TGCTGGAGCCCCCAAAAGTCCCATCTTGGTGAAGATCCGGCCCCACATCTTCTTTGATGA
CCACATGTTCCACATTGAAGGGGCACAGAGGTTAGGTTCCATCGCAGCTTATGGCTTTAA
TAAAAAATTCAGTAGTTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
AF356185

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_3_Locus:
2p24.2

# Metabolic_Enzyme_3_SNPs:
rs3902946; rs16985301; rs16985306; rs3747660; rs2346137; rs6720633; rs7594728; rs6531109; rs6710367; rs7557821; rs4832608; rs11893074; rs16985296; rs7561652; rs2317857; rs16985292; rs16985290; rs6741218; rs11096544; rs35590292; rs10183289; rs17752103; rs11885013; rs17701334; rs16985293; rs11903725; rs7604190; rs4832609; rs7592099; rs16985311; rs16985310; rs3810839; rs17852342; rs34254789; rs7594519; rs34129467; rs7605480; rs35165251; rs7603601; rs34836771; rs34186303; rs35711606; rs35729409; rs34953851; rs11291136; rs28474708; rs3046807; rs34660980; rs35519366; rs3046840; rs35419885; rs7557722; rs4300829; rs7592233; rs13020403; rs36121694; rs34127788; rs11889898; rs13403096; rs13411442; rs1373776; rs16985281; rs16985284; rs17751951; rs2346135; rs2346136; rs34722188; rs35805648; rs3810838; rs3910894

# Metabolic_Enzyme_3_General_References:
11690631

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5229

# Metabolic_Enzyme_4_Name:
5'-nucleotidase precursor

# Metabolic_Enzyme_4_Synonyms:
Ecto-5'-nucleotidase; 5'-NT; CD73 antigen

# Metabolic_Enzyme_4_Gene_Name:
NT5E

# Metabolic_Enzyme_4_Protein_Sequence:
>5'nucleotidase precursor
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ

# Metabolic_Enzyme_4_Number_of_Residues:
574

# Metabolic_Enzyme_4_Molecular_Weight:
63368

# Metabolic_Enzyme_4_Theoretical_pI:
7.04

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  hydrolase activity, acting on ester bonds
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides

# Metabolic_Enzyme_4_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_4_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF02872:5_nucleotid_C;
PF00149:Metallophos

# Metabolic_Enzyme_4_Signals:
1-26

# Metabolic_Enzyme_4_Transmembrane_Regions:
556-573

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
23897

# Metabolic_Enzyme_4_SwissProt_ID:
5NTD_HUMAN (P21589)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
NT5E

# Metabolic_Enzyme_4_Geneatlas_id:
NT5E

# Metabolic_Enzyme_4_hgnc_id:
HGNC:8021

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Metabolic_Enzyme_4_Gene_Sequence:
>1725 bp
ATGTGTCCCCGAGCCGCGCGGGCGCCCGCGACGCTACTCCTCGCCCTGGGCGCGGTGCTG
TGGCCTGCGGCTGGCGCCTGGGAGCTTACGATTTTGCACACCAACGACGTGCACAGCCGG
CTGGAGCAGACCAGCGAGGACTCCAGCAAGTGCGTCAACGCCAGCCGCTGCATGGGTGGC
GTGGCTCGGCTCTTCACCAAGGTTCAGCAGATCCGCCGCGCCGAACCCAACGTGCTGCTG
CTGGACGCCGGCGACCAGTACCAGGGCACTATCTGGTTCACCGTGTACAAGGGCGCCGAG
GTGGCGCACTTCATGAACGCCCTGCGCTACGATGCCATGGCACTGGGAAATCATGAATTT
GATAATGGTGTGGAAGGACTGATCGAGCCACTCCTCAAAGAGGCCAAATTTCCAATTCTG
AGTGCAAACATTAAAGCAAAGGGGCCACTAGCATCTCAAATATCAGGACTTTATTTGCCA
TATAAAGTTCTTCCTGTTGGTGATGAAGTTGTGGGAATCGTTGGATACACTTCCAAAGAA
ACCCCTTTTCTCTCAAATCCAGGGACAAATTTAGTGTTTGAAGATGAAATCACTGCATTA
CAACCTGAAGTAGATAAGTTAAAAACTCTAAATGTGAACAAAATTATTGCACTGGGACAT
TCGGGTTTTGAAATGGATAAACTCATCGCTCAGAAAGTGAGGGGTGTGGACGTCGTGGTG
GGAGGACACTCCAACACATTTCTTTACACAGGCAATCCACCTTCCAAAGAGGTGCCTGCT
GGGAAGTACCCATTCATAGTCACTTCTGATGATGGGCGGAAGGTTCCTGTAGTCCAGGCC
TATGCTTTTGGCAAATACCTAGGCTATCTGAAGATCGAGTTTGATGAAAGAGGAAACGTC
ATCTCTTCCCATGGAAATCCCATTCTTCTAAACAGCAGCATTCCTGAAGATCCAAGCATA
AAAGCAGACATTAACAAATGGAGGATAAAATTGGATAATTATTCTACCCAGGAATTAGGG
AAAACAATTGTCTATCTGGATGGCTCCTCTCAATCATGCCGCTTTAGAGAATGCAACATG
GGCAACCTGATTTGTGATGCAATGATTAACAACAACCTGAGACACACGGATGAAATGTTC
TGGAACCACGTATCCATGTGCATTTTAAATGGAGGTGGTATCCGGTCGCCCATTGATGAA
CGCAACAATGGCACAATTACCTGGGAGAACCTGGCTGCTGTATTGCCCTTTGGAGGCACA
TTTGACCTAGTCCAGTTAAAAGGTTCCACCCTGAAGAAGGCCTTTGAGCATAGCGTGCAC
CGCTACGGCCAGTCCACTGGAGAGTTCCTGCAGGTGGGCGGAATCCATGTGGTGTATGAT
CTTTCCCGAAAACCTGGAGACAGAGTAGTCAAATTAGATGTTCTTTGCACCAAGTGTCGA
GTGCCCAGTTATGACCCTCTCAAAATGGACGAGGTATATAAGGTGATCCTCCCAAACTTC
CTGGCCAATGGTGGAGATGGGTTCCAGATGATAAAAGATGAATTATTAAGACATGACTCT
GGTGACCAAGATATCAACGTGGTTTCTACATATATCTCCAAAATGAAAGTAATTTATCCA
GCAGTTGAAGGTCGGATCAAGTTTTCCACAGGAAGTCACTGCCATGGAAGCTTTTCTTTA
ATATTTCTTTCACTTTGGGCAGTGATCTTTGTTTTATACCAATAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
X55740

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_4_Locus:
6q14-q21

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
2129526; 8566797; 2173922; 9651114

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5805

# Metabolic_Enzyme_5_Name:
Purine nucleoside phosphorylase

# Metabolic_Enzyme_5_Synonyms:
Inosine phosphorylase; PNP

# Metabolic_Enzyme_5_Gene_Name:
NP

# Metabolic_Enzyme_5_Protein_Sequence:
>Purine nucleoside phosphorylase
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS

# Metabolic_Enzyme_5_Number_of_Residues:
289

# Metabolic_Enzyme_5_Molecular_Weight:
32118

# Metabolic_Enzyme_5_Theoretical_pI:
6.95

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  purine-nucleoside phosphorylase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_5_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_5_Reaction:
purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00896:Mtap_PNP

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.4.2.1

# Metabolic_Enzyme_5_GenBank_ID_Protein:
35565

# Metabolic_Enzyme_5_SwissProt_ID:
PNPH_HUMAN (P00491)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
NP

# Metabolic_Enzyme_5_Geneatlas_id:
NP

# Metabolic_Enzyme_5_hgnc_id:
HGNC:7892

# Metabolic_Enzyme_5_PDB_ID:
1RT9

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Not Available

# Metabolic_Enzyme_5_Gene_Sequence:
>870 bp
ATGGAGAACGGATACACCTATGAAGATTATAAGAACACTGCAGAATGGCTTCTGTCTCAT
ACTAAGCACCGACCTCAAGTTGCAATAATCTGTGGTTCTGGATTAGGAGGTCTGACTGAT
AAATTAACTCAGGCCCAGATCTTTGACTACAGTGAAATCCCCAACTTTCCTCGAAGTACA
GTGCCAGGTCATGCTGGCCGACTGGTGTTTGGGTTCCTGAATGGCAGGGCCTGTGTGATG
ATGCAGGGCAGGTTCCACATGTATGAAGGGTACCCACTCTGGAAGGTGACATTCCCAGTG
AGGGTTTTCCACCTTCTGGGTGTGGACACCCTGGTAGTCACCAATGCAGCAGGAGGGCTG
AACCCCAAGTTTGAGGTTGGAGATATCATGCTGATCCGTGACCATATCAACCTACCTGGT
TTCAGTGGTCAGAACCCTCTCAGAGGGCCCAATGATGAAAGGTTTGGAGATCGTTTCCCT
GCCATGTCTGATGCCTACGACCGGACTATGAGGCAGAGGGCTCTCAGTACCTGGAAACAA
ATGGGGGAGCAACGTGAGCTACAGGAAGGCACCTATGTGATGGTGGCAGGCCCCAGCTTT
GAGACTGTGGCAGAATGTCGTGTGCTGCAGAAGCTGGGAGCAGACGCTGTTGGCATGAGT
ACAGTACCAGAAGTTATCGTTGCACGGCACTGTGGACTTCGAGTCTTTGGCTTCTCACTC
ATCACTAACAAGGTCATCATGGATTATGAAAGCCTGGAGAAGGCCAACCATGAAGAAGTC
TTAGCAGCTGGCAAACAAGCTGCACAGAAATTGGAACAGTTTGTCTCCATTCTTATGGCC
AGCATTCCACTCCCTGACAAAGCCAGTTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X00737

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_5_Locus:
14q13.1

# Metabolic_Enzyme_5_SNPs:
rs1049564; rs1130650; rs1049562; rs7785; rs1617940; rs1760940; rs1713420; rs1760935; rs1713422; rs1713421; rs3790064; rs3790065; rs1713429; rs17882804; rs17880405; rs1756369; rs12147688; rs8008133; rs17881431; rs17881345; rs7154909; rs17883821; rs17885781; rs1760934; rs17879107; rs17880844; rs17879913; rs17881184; rs17885714; rs17880480; rs17883253; rs17878900; rs1713426; rs17881356; rs1713427; rs1760933; rs3790062; rs17883795; rs17112168; rs17880290; rs12147906; rs17881554; rs17881206; rs1049700; rs17882836; rs12101049; rs17884106; rs12147035; rs34480769; rs3838361; rs3842517; rs1760939; rs17885917; rs17886095; rs1760938; rs17883294; rs17883604; rs8019880; rs17881280; rs35549071; rs35139440; rs17880503; rs7151666; rs10498268; rs1079375; rs1079376; rs11846743; rs11850059; rs11850069; rs12587218; rs12886203; rs12888804; rs12891271; rs13379232; rs13379234; rs1629478; rs17112384; rs17112385; rs1713459; rs1713460; rs1713461; rs1713462; rs17242655; rs17242662; rs17242669; rs1756365; rs1760930; rs1760931; rs1760941; rs1760942; rs2077153; rs2481768; rs35175606; rs35567022; rs7156659; rs755777

# Metabolic_Enzyme_5_General_References:
6087295; 3029074; 12928150; 2104852; 1384322; 8931706

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5233

# Metabolic_Enzyme_6_Name:
Cytosolic 5'-nucleotidase 1A

# Metabolic_Enzyme_6_Synonyms:
Cytosolic 5'-nucleotidase IA; cN1A; cN-IA; cN-I

# Metabolic_Enzyme_6_Gene_Name:
NT5C1A

# Metabolic_Enzyme_6_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
AMEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSR
ALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSED
VFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKV
REAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKA
HENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSW
GLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTA
PAKQAPSAQ

# Metabolic_Enzyme_6_Number_of_Residues:
368

# Metabolic_Enzyme_6_Molecular_Weight:
41021

# Metabolic_Enzyme_6_Theoretical_pI:
6.52

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia

# Metabolic_Enzyme_6_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_6_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_6_GenBank_ID_Protein:
12659324

# Metabolic_Enzyme_6_SwissProt_ID:
5NT1A_HUMAN (Q9BXI3)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
NT5C1A

# Metabolic_Enzyme_6_Geneatlas_id:
NT5C1A

# Metabolic_Enzyme_6_hgnc_id:
HGNC:17819

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_6_Gene_Sequence:
>1107 bp
ATGGAACCTGGGCAGCCCCGGGAGCCCCAGGAGCCCCGCGAGCCCGGGCCAGGAGCGGAG
ACCGCTGCGGCCCCGGTCTGGGAGGAAGCCAAGATTTTCTACGACAACCTCGCGCCCAAG
AAGAAACCCAAATCGCCCAAGCCTCAGAATGCAGTCACCATCGCTGTGTCCTCCCGAGCC
TTGTTTCGCATGGACGAGGAGCAGCAGATCTACACGGAGCAGGGCGTGGAGGAGTACGTG
CGCTACCAGCTGGAACATGAGAACGAACCCTTCAGTCCCGGGCCAGCCTTCCCTTTTGTG
AAGGCTCTGGAGGCCGTGAACAGGCGGCTGCGGGAGCTGTACCCTGATAGTGAGGACGTC
TTCGACATCGTCCTCATGACTAACAACCATGCTCAAGTGGGTGTCCGCCTCATCAACAGT
ATCAACCACTATGACCTGTTCATCGAGAGGTTCTGCATGACAGGTGGGAACAGCCCGATC
TGCTACCTCAAGGCCTATCACACCAACCTCTACTTGTCAGCCGATGCGGAAAAAGTGCGA
GAAGCCATTGATGAGGGGATCGCAGCTGCCACCATCTTCAGCCCCAGCAGGGATGTGGTT
GTGTCCCAGAGTCAGCTGCGCGTGGCCTTCGATGGGGACGCCGTGCTCTTCTCGGACGAG
TCGGAGCGCATCGTCAAGGCCCACGGGCTGGACCGATTCTTCGAGCATGAGAAGGCCCAC
GAGAACAAGCCTCTGGCTCAGGGCCCCTTAAAGGGCTTTCTGGAGGCACTGGGTAGGTTG
CAGAAGAAGTTCTACTCCAAAGGCCTGCGGCTGGAGTGCCCAATTCGTACCTACTTGGTG
ACAGCACGCAGTGCAGCCAGTTCCGGGGCCCGGGCTCTCAAGACCCTGCGCAGCTGGGGC
CTGGAGACAGATGAAGCCTTGTTCCTTGCTGGAGCGCCCAAGGGCCCTCTCCTTGAGAAG
ATCCGCCCACACATCTTCTTTGATGACCAGATGTTCCATGTGGCTGGGGCTCAGGAGATG
GGCACTGTGGCCGCCCATGTGCCTTATGGTGTGGCACAGACACCCCGGCGGACTGCACCT
GCAAAGCAGGCCCCATCTGCACAGTAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AF331801

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_6_Locus:
1p34.3-p33

# Metabolic_Enzyme_6_SNPs:
rs4660340; rs784611; rs752667; rs1180272; rs1180271; rs784595; rs873917; rs1568146; rs1535031; rs3851911; rs17264901; rs784596; rs12566856; rs12406284; rs11807200; rs784597; rs784610; rs734497; rs3806428; rs784600; rs11809004; rs7553293; rs3806433; rs16826428; rs9660121; rs784599; rs3806429; rs784612; rs1533479; rs2871601; rs41264507; rs34479837; rs12035327; rs1180270; rs9439008; rs35574502; rs34779558; rs36025518; rs36123767; rs35625235; rs28507686; rs35550484; rs11206573; rs41264509; rs784598; rs34604809; rs1535030; rs5773668; rs1517187; rs12039176; rs28592113; rs784594; rs9438930; rs11306359; rs35355327; rs6684666; rs34908371; rs28667717; rs3806432; rs5773667; rs7416372; rs34045723; rs6672154; rs35002774; rs35256759; rs3806431; rs12042601; rs10465833; rs1062103; rs10839; rs10888919; rs10888929; rs11206525; rs1180275; rs1180277; rs12039225; rs12042356; rs12565281; rs13315; rs16826440; rs17501838; rs17560858; rs2281302; rs2746057; rs3207766; rs3806434; rs3916165; rs6663003; rs6703320; rs704769; rs736009; rs7419080; rs784601; rs784602; rs784613; rs784615; rs784616; rs784627; rs784629; rs784630; rs813052

# Metabolic_Enzyme_6_General_References:
11133996

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5234

# Metabolic_Enzyme_7_Name:
5'(3')-deoxyribonucleotidase, cytosolic type

# Metabolic_Enzyme_7_Synonyms:
Cytosolic 5',3'-pyrimidine nucleotidase; Deoxy-5'-nucleotidase 1; dNT-1

# Metabolic_Enzyme_7_Gene_Name:
NT5C

# Metabolic_Enzyme_7_Protein_Sequence:
>5'3'deoxyribonucleotidase, cytosolic type
MARSVRVLVDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADK
VASVYEAPGFFLDLEPIPGALDAVREMNDLPDTQVFICTSPLLKYHHCVGEKYRWVEQHL
GPQFVERIILTRDKTVVLGDLLIDDKDTVRGQEETPSWEHILFTCCHNRHLVLPPTRRRL
LSWSDNWREILDSKRGAAQRE

# Metabolic_Enzyme_7_Number_of_Residues:
201

# Metabolic_Enzyme_7_Molecular_Weight:
23383

# Metabolic_Enzyme_7_Theoretical_pI:
6.63

# Metabolic_Enzyme_7_GO_Classification:
Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
Not Available

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_7_GenBank_ID_Protein:
7524492

# Metabolic_Enzyme_7_SwissProt_ID:
NT5C_HUMAN (Q8TCD5)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
NT5C

# Metabolic_Enzyme_7_Geneatlas_id:
NT5C

# Metabolic_Enzyme_7_hgnc_id:
HGNC:17144

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_7_Gene_Sequence:
>606 bp
ATGGCGCGGAGCGTGCGCGTGCTGGTGGACATGGACGGCGTCCTGGCCGACTTCGAGGCC
GGCCTCCTGCGGGGCTTCCGCCGCCGCTTCCCTGAGGAGCCGCACGTGCCGCTGGAGCAA
CGCCGCGGCTTCCTGGCCCGCGAGCAGTACCGCGCCCTGCGGCCCGACCTGGCGGATAAA
GTGGCCAGTGTGTACGAAGCCCCGGGCTTTTTCCTGGACCTGGAGCCCATCCCGGGAGCC
TTGGACGCTGTGCGGGAGATGAACGACCTACCGGACACGCAGGTCTTCATCTGCACCAGC
CCCCTGCTGAAGTACCACCACTGTGTGGGTGAGAAGTACCGCTGGGTGGAGCAGCACCTG
GGGCCCCAGTTCGTAGAACGAATTATCCTGACAAGGGACAAGACGGTGGTCTTGGGGGAC
CTGCTCATTGATGACAAGGACACAGTTCGAGGCCAGGAGGAGACCCCAAGCTGGGAGCAC
ATCTTGTTCACCTGCTGCCACAATCGGCACCTGGTCCTGCCCCCGACAAGGAGACGGCTG
CTCTCCTGGAGTGACAACTGGAGGGAGATCTTAGATAGCAAGCGCGGAGCTGCGCAGCGG
GAATGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AF154829

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_7_Locus:
17q25.1

# Metabolic_Enzyme_7_SNPs:
rs4788867; rs11868451; rs3736076; rs3736075; rs12453556; rs4789144; rs11652099; rs4789143; rs11541956; rs12945569; rs3188816; rs12946860; rs1048779; rs12943507; rs34746270; rs11541955; rs12945517; rs9910084; rs34454120; rs7406461; rs4788868; rs11868212; rs1551966; rs2291027; rs2291028; rs34338273; rs3752801; rs4412997; rs4789145; rs750843; rs750844; rs899316; rs899317

# Metabolic_Enzyme_7_General_References:
10681516; 12234672

# Metabolic_Enzyme_7_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7549

# Macromolecular_Interacting_Partner_1_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
INS

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_1_Signals:
1-24

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
INS

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11p15.5

# Macromolecular_Interacting_Partner_1_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_1_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_1_References:
10812942; 1437998; 2664393; 6800439

# Macromolecular_Interacting_Partner_2_ID:
7556

# Macromolecular_Interacting_Partner_2_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_2_Signals:
1-18

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_2_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_2_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_2_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_2_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_2_References:
12220302; 3771262; 558065; 7053338

# Macromolecular_Interacting_Partner_3_ID:
7803

# Macromolecular_Interacting_Partner_3_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_3_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_3_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_3_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_3_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_3_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_3_SNPs:
Not Available

# Macromolecular_Interacting_Partner_3_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_3_References:
6165641

End of HMDB00138

Beginning of HMDB00139
# Accession_No:
HMDB00139

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-17 13:13:02

# biospider_lastupdate:
2007-07-26 09:30:50

# Common_Name:
Glyceric acid

# Description:
A colorless syrupy acid, obtained from oxidation of glycerol.  It is a compound that is secreted excessively in the urine by patients suffering from D-glyceric aciduria and D-glycerate anemia.  Deficiency of human glycerate kinase leads to D-glycerate acidemia/D-glyceric aciduria.  Symptoms of the disease include progressive neurological impairment, hypotonia, seizures, failure to thrive and metabolic acidosis.

# Synonyms:
D-Glycerate; D-Glyceric acid; Glycerate; Glyceric acid; a,b-Hydroxypropionate; a,b-Hydroxypropionic acid

# Chemical_IUPAC_Name:
2,3-dihydroxypropanoic acid

# Chemical_Formula:
C3H6O4

# Chemical_Structure:
tbl_chemical:::HMDB00139_ZOOM.png:::119283213128720271

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00139_THUMB.png:::119283212968856950

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary alcohol; secondary alcohol; 1,2-diol; carboxylic acid; alpha-hydroxyacid

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
106.02661

# Molecular_Weight_Avg:
106.07735

# Smiles_String_isomeric:
OC[C@@H](O)C(O)=O

# Smiles_String_canonical:
OCC(O)C(O)=O

# KEGG_Compound_ID:
C00258

# BioCyc_ID:
2-PG

# PubChem_CID:
439194

# PubChem_SID:
3557; 7887013; 6436423; 14710384; 8145330; 10298241

# OMIM_ID:
220120; 260000

# Metagene_ID:
PRIMARY HYPEROXALURIA II, PH2: 183; D-GLYCERIC ACIDURA: 114

# BiGG_ID:
34424

# Wikipedia_ID:
Not Available

# METLIN_ID:
280

# Ref_ID:
11930278; 14708889; 8087979; 9267307; 2551543; 8412012; 1444166; 11920944

# ChEBI_ID:
16659

# CAS_Registry_Number:
473-81-4

# InChI:
InChI=1/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/t2-/m1/s1

# Synthesis_Reference:
Journal of the American Chemical Society  (1939),  61  2607-9.

# Melting_Point:
Not Available

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
1000.0 mg/mL [MERCK INDEX (1996)]

# H2O_Solubility_Predicted:
639.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Liquid

# LogP:
Not Available

# LogP_predicted:
-1.71 [Predicted by ALOGPS]; -1.7 [Predicted by PubChem via XLOGP]; -0.51 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Glyceric acid hemicalcium.pdf:::1132562205276204216

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00139.mol:::11763354349466405

# SDF_File_[Text]:
tbl_chemical:::HMDB00139.sdf:::119283212630565317

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00139.pdb:::119283212794452354

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041009_P00_01_IS_1DP_PRESAT_expanded_2.gif:::114460741708268597

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041009_P00_01_IS_1DP_presat.zip:::1177710580421191505

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::glyceric_acid.png:::114351788665410643

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041009_P00_01_IS_2DHSQC_639.png:::1147815185874688

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041009_P00_01_IS_2DHSQC_639.zip:::114781518588842221

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041009_P00_01_IS_2DHSQC_639_Assigned.png:::114781518603114243

# Predicted_H_NMR_Spectrum:
tbl_chemical:::glyceric acid.gif:::1132732113156869256

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00139_peaks.txt:::1156309571026464284

# Predicted_C_NMR_Spectrum:
tbl_chemical:::glyceric acid_C.gif:::1132737697254423624

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00139_peaks.txt:::1156310760928929395

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00139L.png:::117555262506740590; Medium Energy:tbl_ms:::HMDB00139M.png:::117555267864838717; High Energy:tbl_ms:::HMDB00139H.png:::117555271468343046

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP)

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	8.9	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	8087979
Urine	4.0	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	5.3	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	3.5	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	4.1	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	14708889
Urine	20.4	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	14708889
Urine	18.9	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	14708889
Urine	3.5 (2.8 - 4.2)	umol/mmol_creatinine	Adolescent:13-18_yrs_old	Both	Normal	14708889
Blood	10.0 (0.0-24.0)	umol/L	Adult:>18_yrs_old	Both	Normal	8412012
Cerebrospinal_Fluid(CSF)	34.0+/- 34.0	umol/L	Adult:>18_yrs_old	N/A	Normal	8412012
N/A	21.6	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	


# Concentration_[Abnormal]:
Urine	2360.0 (1.2 - 1450.0)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Primary Hyperoxaluria II, PH2	9267307


# Associated_Disorders:
D-glyceric Acidura; Primary Hyperoxaluria II, PH2

# Pathway_Names:
Glycolysis;Fatty acid metabolism;Bile acid biosynthesis;Valine, leucine and isoleucine degradation;Lysine degradation;Glycerolipid metabolism;Pyruvate metabolism;Propanoate metabolism;Butanoate metabolism;Glyoxylate and dicarboxylate metabolism;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
Glycolysis.jpg;;;valine,leucine,and_isoleucine_degradation.jpg;Lysine_degradation.jpg;;;;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00010;map00071;map00120;map00280;map00310;map00561;map00620;map00640;map00650;map00630;map00280;map00280

# Pathway_Graphs:
Glycolysis_Graph.jpg;;;valine,leucine,and_isoleucine_degradation_Graph.jpg;Lysine_degradation_Graph.jpg;;;;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
Glycolysis.xml;;;valine,leucine,and_isoleucine_degradation.xml;Lysine_degradation.xml;;;;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5532

# Metabolic_Enzyme_1_Name:
Aldehyde dehydrogenase X, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
Aldehyde dehydrogenase family 1 member B1; ALDH class 2

# Metabolic_Enzyme_1_Gene_Name:
ALDH1B1

# Metabolic_Enzyme_1_Protein_Sequence:
>Aldehyde dehydrogenase X, mitochondrial precursor
MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT
TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNLLADLVERDRVYLA
SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCG
QIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITG
YGPTAGAAIAQHMDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADM
EHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGP
QVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP
VQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHT
PFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS

# Metabolic_Enzyme_1_Number_of_Residues:
517

# Metabolic_Enzyme_1_Molecular_Weight:
57239

# Metabolic_Enzyme_1_Theoretical_pI:
6.79

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation

# Metabolic_Enzyme_1_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_1_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_1_Signals:
1-22

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1263008

# Metabolic_Enzyme_1_SwissProt_ID:
AL1B1_HUMAN (P30837)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ALDH1B1

# Metabolic_Enzyme_1_Geneatlas_id:
ALDH1B1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:407

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_1_Gene_Sequence:
>1554 bp
ATGCTGCGCTTCCTGGCACCCCGGCTGCTTAGCCTCCAGGGCAGGACCGCCCTCTACTCC
TCGGCAGCAGCCCTCCCAAGCCCCATTCTGAACCCAGACATCCCCTACAACCAGCTGTTC
ATCAACAATGAATGGCAAGATGCAGTCAGCAAGAAGACCTTCCCGACGGTCAACCCTACC
ACCGGGGAGGTCATCGGGCACGTGGCTGAAGGTGACCGGGCTGATGTGGATCGGGCCGTG
AAAGCAGCCCGGGAAGCCTTCCGCCTGGGGTCCCCATGGCGCCGGATGGATGCCTCTGAG
CGGGGCCGGCTGCTGAACCTCCTGGCAGACCTAGTGGAGCGGGATCGAGTCTACTTGGCC
TCACTCGAGACCTTGGACAATGGGAAGCCTTTCCAAGAGTCTTACGCCTTGGACTTGGAT
GAGGTCATCAAGGTGTATCGGTACTTTGCTGGCTGGGCTGACAAGTGGCATGGCAAGACC
ATCCCCATGCATGGCCAGCATTTCTGCTTCACCCGGCATGAGCCCGTTGGTGTCTGTGGC
CAGATCATCCCGTGGAACTTCCCCTTGGTCATGCAGGGTTGGAAACTTGCCCCGGCACTC
GCCACAGGCAACACTGTGGTTATGAAGGTGGCAGAGCAGACCCCCCTCTCTGCCCTGTAT
TTGGCCTCCCTCATCAAGGAGGCAGGCTTTCCCCCTGGGGTGGTGAACATCATCACGGGG
TATGGCCCAACAGCAGGTGCGGCCATCGCCCAGCACATGGATGTTGACAAAGTTGCCTTC
ACCGGTTCCACCGAGGTGGGCCACCTGATCCAGAAAGCAGCTGGCGATTCCAACCTCAAG
AGAGTCACCCTGGAGCTGGGTGGTAAGAGCCCCAGCATCGTGCTGGCCGATGCTGACATG
GAGCATGCCGTGGAGCAGTGCCACGAAGCCCTGTTCTTCAACATGGGCCAGTGCTGCTGT
GCTGGCTCCCGGACCTTCGTGGAAGAATCCATCTACAATGAGTTTCTCGAGAGAACCGTG
GAGAAAGCAAAGCAGAGGAAAGTGGGGAACCCCTTTGAGCTGGACACCCAGCAGGGGCCT
CAGGTGGACAAGGAGCAGTTTGAACGAGTCCTAGGCTACATCCAGCTTGGCCAGAAGGAG
GGCGCAAAACTCCTCTGTGGCGGAGAGCGTTTCGGGGAGCGTGGTTTCTTCATCAAGCCT
ACTGTCTTTGGTGGCGTGCAGGATGACATGAGAATTGCCAAAGAGGAGATCTTTGGGCCT
GTGCAGCCCCTGTTCAAGTTCAAGAAGATTGAGGAGGTGGTTGAGAGGGCCAACAACACC
AGGTATGGCCTGGCTGCGGCTGTGTTCACCCGGGATCTGGACAAGGCCATGTACTTCACC
CAGGCACTCCAGGCCGGGACCGTGTGGGTAAACACCTACAACATCGTCACCTGCCACACG
CCATTTGGAGGGTTTAAGGAATCTGGAAACGGGAGGGAGCTGGGTGAGGATGGGCTTAAG
GCCTACACAGAGGTAAAGACGGTCACCATCAAGGTTCCTCAGAAGAACTCGTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M63967

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_1_Locus:
9p11.1

# Metabolic_Enzyme_1_SNPs:
rs2228093; rs4878199; rs2073478; rs2073477; rs2228094; rs3043; rs6476701; rs10758494; rs10758495; rs7859877; rs4646772; rs4646774; rs4878802; rs10738997; rs11555705; rs4646773; rs41278335; rs11555706; rs10973781; rs10973782; rs12343271; rs41278337; rs10118683; rs10758496; rs10814687; rs10973774; rs10973779; rs10973783; rs10973785; rs10973786; rs10973787; rs10973789; rs10973792; rs11361; rs11790480; rs11791018; rs11791622; rs12001093; rs12336048; rs12352007; rs12378762; rs13285234; rs13290293; rs1555480; rs1923423; rs1923424; rs2038589; rs34183602; rs35950473; rs4142260; rs4242647; rs4878203; rs4878800; rs4878801; rs4878804; rs4878805; rs4878806; rs4878807; rs4878808; rs4878809; rs4878811; rs6476703; rs7021469; rs7031628; rs7045542; rs7046137; rs7853954; rs7865905; rs7866277; rs7867383; rs911757; rs911758

# Metabolic_Enzyme_1_General_References:
2061311; 8244338

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5528

# Metabolic_Enzyme_2_Name:
Alpha-aminoadipic semialdehyde dehydrogenase

# Metabolic_Enzyme_2_Synonyms:
Alpha-AASA dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenease; P6c dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1

# Metabolic_Enzyme_2_Gene_Name:
ALDH7A1

# Metabolic_Enzyme_2_Protein_Sequence:
>Alphaaminoadipic semialdehyde dehydrogenase
MSTLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADY
EETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQ
EYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIA
MICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVN
LLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQ
RCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEA
KKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWN
NEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRES
GSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ

# Metabolic_Enzyme_2_Number_of_Residues:
511

# Metabolic_Enzyme_2_Molecular_Weight:
55367

# Metabolic_Enzyme_2_Theoretical_pI:
6.86

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H

# Metabolic_Enzyme_2_Pathway:
map00300  Lysine biosynthesis;
 map00310  Lysine degradation

# Metabolic_Enzyme_2_Reaction:
L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.2.1.31

# Metabolic_Enzyme_2_GenBank_ID_Protein:
797410

# Metabolic_Enzyme_2_SwissProt_ID:
AL7A1_HUMAN (P49419)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ALDH7A1

# Metabolic_Enzyme_2_Geneatlas_id:
ALDH7A1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:877

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>1536 bp
ATGTCCACTCTCCTCATCAATCAGCCCCAGTATGCGTGGCTGAAAGAGCTGGGGCTCCGC
GAGGAAAACGAGGGCGTGTATAATGGAAGCTGGGGAGGCCGGGGAGAGGTTATTACGACC
TATTGCCCCGCTAACAACGAGCCAATAGCAAGAGTCCGACAGGCCAGTGTGGCAGACTAT
GAAGAAACTGTAAAGAAAGCAAGAGAAGCATGGAAAATCTGGGCAGATATTCCTGCTCCA
AAACGAGGAGAAATAGTAAGACAGATTGGCGATGCCTTGCGGGAGAAGATCCAAGTACTA
GGAAGCTTGGTGTCTTTGGAGATGGGGAAAATCTTAGTGGAAGGTGTGGGTGAAGTTCAG
GAGTATGTGGATATCTGTGACTATGCTGTTGGTTTATCAAGGATGATTGGAGGACCTATC
TTGCCTTCTGAAAGATCTGGCCATGCACTGATTGAGCAGTGGAATCCCGTAGGCCTGGTT
GGAATCATCACGGCATTCAATTTCCCTGTGGCAGTGTATGGTTGGAACAACGCCATCGCC
ATGATCTGTGGAAATGTCTGCCTCTGGAAAGGAGCTCCAACCACTTCCCTCATTAGTGTG
GCTGTCACAAAGATAATAGCCAAGGTTCTGGAGGACAACAAGCTGCCTGGTGCAATTTGT
TCCTTGACTTGTGGTGGAGCAGATATTGGCACAGCAATGGCCAAAGATGAACGAGTGAAC
CTGCTGTCCTTCACTGGGAGCACTCAGGTGGGAAAACAGGTGGGCCTGATGGTGCAGGAG
AGGTTTGGGAGAAGTCTGTTGGAACTTGGAGGAAACAATGCCATTATTGCCTTTGAAGAT
GCAGACCTCAGCTTAGTTGTTCCATCAGCTCTCTTCGCTGCTGTGGGAACAGCTGGCCAG
AGGTGTACCACTGCGAGGCGACTGTTTATACATGAAAGCATCCATGATGAGGTTGTAAAC
AGACTTAAAAAGGCCTATGCACAGATCCGAGTTGGGAACCCATGGGACCCTAATGTTCTC
TATGGGCCACTCCACACCAAGCAGGCAGTGAGCATGTTTCTTGGAGCAGTGGAAGAAGCA
AAGAAAGAAGGTGGCACAGTGGTCTATGGGGGCAAGGTTATGGATCGCCCTGGAAATTAT
GTAGAACCGACAATTGTGACAGGTCTTGGCCACGATGCGTCCATTGCACACACAGAGACT
TTCGCTCCGATTCTCTATGTCTTTAAATTCAAGAATGAAGAAGAGGTCTTTGCATGGAAT
AATGAAGTAAAACAGGGACTTTCAAGTAGCATCTTTACCAAAGATCTGGGCAGAATCTTT
CGCTGGCTTGGACCTAAAGGATCAGACTGTGGCATTGTAAATGTCAACATTCCAACAAGT
GGGGCTGAGATTGGAGGTGCCTTTGGAGGAGAAAAGCACACTGGTGGTGGCAGGGAGTCT
GGCAGTGATGCCTGGAAACAGTACATGAGAAGGTCTACTTGTACTATCAACTACAGTAAA
GACCTTCCTCTGGCCCAAGGAATCAAGTTTCAGTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
S74728

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_2_Locus:
5q31

# Metabolic_Enzyme_2_SNPs:
rs12514417; rs2306618; rs2775; rs1038381; rs6595719; rs4835912; rs1038378; rs1038380; rs2306617; rs4379190; rs4836276; rs11241901; rs4240406; rs12513847; rs7709115; rs4836272; rs7713264; rs6870785; rs11241902; rs7714044; rs1038379; rs10050642; rs7723008; rs4836277; rs3734175; rs6898430; rs17154671; rs4626334; rs13182402; rs17154679; rs4835914; rs12653605; rs2306619; rs7719675; rs10478743; rs7700981; rs2035472; rs11241903; rs6861395; rs7724875; rs2291295; rs10519915; rs7719712; rs6898559; rs4626335; rs17154676; rs11952752; rs13179664; rs4835913; rs11742214; rs3734174; rs11742381; rs7736031; rs7737529; rs10478744; rs4836275; rs17154666; rs34241005; rs10043987; rs7718426; rs2013986; rs10067785; rs7719091; rs17165056; rs13188450; rs900645; rs7708281; rs7703958; rs7723494; rs10050872; rs7702811; rs13171814; rs6897789; rs13177576; rs7704283; rs4526102; rs11741551; rs10038571; rs4836273; rs3736174; rs3736171; rs1483780; rs900641; rs744722; rs900640; rs7718710; rs1060856; rs744720; rs17165061; rs744721; rs1807; rs6865317; rs6884473; rs7447092; rs3189320; rs1049217; rs1049211; rs11542969; rs1049214; rs11269202; rs6898845; rs35027610; rs35284915; rs34275373; rs35570062; rs34674137; rs28429591; rs7730016; rs4612066; rs36058537; rs2408702; rs11406545; rs1142071; rs13356526; rs35492150; rs34697893; rs10539406; rs34825424; rs7703752; rs12187161; rs34949719; rs36125577; rs36077292; rs7719949; rs35736560; rs34201518; rs33926729; rs34250591; rs13185811; rs34323751; rs34907915; rs28865092; rs35559498; rs35109136; rs10630162; rs4836274; rs34972014; rs13173864; rs7709981; rs6870070; rs2408703; rs35118533; rs10532390; rs34517958; rs34069611; rs10629966; rs7706009; rs34496788; rs34935903; rs35115612; rs13174679; rs10609859; rs34995966; rs34074703; rs36120385; rs34424711; rs34537297; rs7737783; rs35457522; rs35367836; rs36017518; rs17597559; rs7730933; rs33954485; rs35196030; rs35930104; rs34575294; rs10666972; rs10676689; rs35010266; rs34035179; rs28629815; rs7704352; rs35797169; rs10044223; rs35622239; rs35960414; rs34959052; rs35342756; rs13154789; rs4836278; rs35617751; rs34731336; rs12656014; rs34305021; rs34684581; rs5871220; rs11951146; rs35290920; rs13166319; rs2408633; rs11290126; rs34862437; rs35992646; rs35110442; rs10609860; rs11742868; rs6896807; rs17531712; rs34770295; rs3080835; rs11387172; rs7737256; rs34601459; rs9765047; rs1060857; rs3736172; rs11458774; rs1138001; rs7447380; rs5871218; rs1138005; rs34410568; rs3736173; rs35569843; rs744723; rs5871219; rs34450389; rs34135005; rs3830274; rs11750167; rs1384880; rs17154635; rs2035471; rs2128931; rs2306620; rs2306621; rs2306622; rs2408700; rs28365789; rs3734173; rs4240405; rs4597966; rs4835911; rs4836271; rs6882015; rs730870; rs7715516; rs7726892

# Metabolic_Enzyme_2_General_References:
8088832; 9417906

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5628

# Metabolic_Enzyme_3_Name:
Glyoxylate reductase/hydroxypyruvate reductase

# Metabolic_Enzyme_3_Synonyms:
Not Available

# Metabolic_Enzyme_3_Gene_Name:
GRHPR

# Metabolic_Enzyme_3_Protein_Sequence:
>Glyoxylate reductase/hydroxypyruvate reductase
MRPVRLMKVFVTRRIPAEGRVALARAADCEVEQWDSDEPIPAKELERGVAGAHGLLCLLS
DHVDKRILDAAGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLL
TTCRRLPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRF
LYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVF
INISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIGSATHR
TRNTMSLLAANNLLAGLRGEPMPSELKL

# Metabolic_Enzyme_3_Number_of_Residues:
328

# Metabolic_Enzyme_3_Molecular_Weight:
35669

# Metabolic_Enzyme_3_Theoretical_pI:
7.44

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  L-serine metabolism
Process:  L-serine biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities

# Metabolic_Enzyme_3_Pathway:
map00620  Pyruvate metabolism;
 map00630  Glyoxylate and dicarboxylate metabolism

# Metabolic_Enzyme_3_Reaction:
glycolate + NADP+ = glyoxylate + NADPH + H+

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00389:2-Hacid_dh;
PF02826:2-Hacid_dh_C

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.1.1.79

# Metabolic_Enzyme_3_GenBank_ID_Protein:
6002730

# Metabolic_Enzyme_3_SwissProt_ID:
GRHPR_HUMAN (Q9UBQ7)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
GRHPR

# Metabolic_Enzyme_3_Geneatlas_id:
GRHPR

# Metabolic_Enzyme_3_hgnc_id:
HGNC:4570

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>987 bp
ATGAGACCGGTGCGACTCATGAAGGTGTTCGTCACCCGCAGGATACCCGCCGAGGGTAGG
GTCGCGCTCGCCCGGGCGGCAGACTGTGAGGTGGAGCAGTGGGACTCGGATGAGCCCATC
CCTGCCAAGGAGCTAGAGCGAGGTGTGGCGGGGGCCCACGGCCTGCTCTGCCTCCTCTCC
GACCACGTGGACAAGAGGATCCTGGATGCTGCAGGGGCCAATCTCAAAGTCATCAGCACC
ATGTCTGTGGGCATCGACCACTTGGCTTTGGATGAAATCAAGAAGCGTGGGATCCGAGTT
GGCTACACCCCAGATGTCCTGACAGATACCACCGCCGAACTCGCAGTCTCCCTGCTACTT
ACCACCTGCCGCCGGTTGCCGGAGGCCATCGAGGAAGTGAAGAATGGTGGCTGGACCTCG
TGGAAGCCCCTCTGGCTGTGTGGCTATGGACTCACGCAGAGCACTGTCGGCATCATCGGG
CTGGGGCGCATAGGCCAGGCCATTGCTCGGCGTCTGAAACCATTCGGTGTCCAGAGATTT
CTGTACACAGGGCGCCAGCCCAGGCCTGAGGAAGCAGCAGAATTCCAGGCAGAGTTTGTG
TCTACCCCTGAGCTGGCTGCCCAATCTGATTTCATCGTCGTGGCCTGCTCCTTAACACCT
GCAACCGAGGGACTCTGCAACAAGGACTTCTTCCAGAAGATGAAGGAAACAGCTGTGTTC
ATCAACATCAGCAGGGGCGACGTCGTAAACCAGGACGACCTGTACCAGGCCTTGGCCAGT
GGTAAGATTGCAGCTGCTGGACTGGATGTGACGAGCCCAGAACCACTGCCTACAAACCAC
CCTCTCCTGACCCTGAAGAACTGTGTGATTCTGCCCCACATTGGCAGTGCCACCCACAGA
ACCCGCAACACCATGTCCTTGTTGGCAGCTAACAACTTGCTGGCTGGCCTGAGAGGGGAG
CCGATGCCTAGTGAACTCAAGCTGTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
AF134895

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_3_Locus:
9q12

# Metabolic_Enzyme_3_SNPs:
rs12002324; rs309458; rs309461; rs2768659; rs2736664; rs2768662; rs7867764; rs309455; rs309459; rs1887454; rs309453; rs2768658; rs12552734; rs309452; rs309460; rs309457; rs2235096; rs10973333; rs309456; rs309462; rs17885933; rs17411423; rs12683277; rs10973336; rs2768657; rs10973334; rs309454; rs4472607; rs7856656; rs4878690; rs7872991; rs10973329; rs7853540; rs7857159; rs10973327; rs10973328; rs7872720; rs6476631; rs7853526; rs11546642; rs35975284; rs11546644; rs1057507; rs3198078; rs2736669; rs2736662; rs2768660; rs2736670; rs35891798; rs2736673; rs34288288; rs41278295; rs41298174; rs2736665; rs2736660; rs2736667; rs10973335; rs2736671; rs2736661; rs41303225; rs16934118; rs2736663; rs1807410; rs35417895; rs2736666; rs2736674; rs10643023; rs2736668; rs34302950; rs11345501; rs2736672; rs309451; rs13299681; rs10973331; rs10679296; rs34280344; rs10973332; rs35292277; rs34688490; rs34632389; rs10643132; rs5897688; rs927929; rs34510989; rs10814535; rs10973324; rs10973338; rs10973339; rs10973340; rs11793053; rs12348205; rs13300415; rs17411255; rs17502738; rs1802995; rs2840246; rs309450; rs35680410; rs35720597; rs7022431; rs7031029; rs7038960; rs7039333

# Metabolic_Enzyme_3_General_References:
10524214; 10484776; 10679197

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5531

# Metabolic_Enzyme_4_Name:
Fatty aldehyde dehydrogenase

# Metabolic_Enzyme_4_Synonyms:
Aldehyde dehydrogenase, microsomal; Aldehyde dehydrogenase family 3 member A2; Aldehyde dehydrogenase 10

# Metabolic_Enzyme_4_Gene_Name:
ALDH3A2

# Metabolic_Enzyme_4_Protein_Sequence:
>Fatty aldehyde dehydrogenase
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE
VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ
PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH
IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT
CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI
AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA
LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS
HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV
KAEYY

# Metabolic_Enzyme_4_Number_of_Residues:
485

# Metabolic_Enzyme_4_Molecular_Weight:
54849

# Metabolic_Enzyme_4_Theoretical_pI:
7.99

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length

# Metabolic_Enzyme_4_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_4_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
464-480

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_4_GenBank_ID_Protein:
1082036

# Metabolic_Enzyme_4_SwissProt_ID:
AL3A2_HUMAN (P51648)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
ALDH3A2

# Metabolic_Enzyme_4_Geneatlas_id:
ALDH3A2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:403

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein; cytoplasmic side

# Metabolic_Enzyme_4_Gene_Sequence:
>1458 bp
ATGGAGCTCGAAGTCCGGCGGGTCCGACAGGCGTTCCTGTCCGGCCGGTCGCGACCTCTG
CGGTTTCGGCTGCAGCAGCTGGAGGCCCTGCGGAGGATGGTGCAGGAGCGCGAGAAGGAT
ATCCTGACGGCCATCGCCGCCGACCTGTGCAAGAGTGAATTCAATGTGTACAGTCAGGAA
GTCATTACTGTCCTTGGGGAAATTGATTTTATGCTTGAGAATCTTCCTGAATGGGTTACT
GCTAAACCAGTTAAGAAGAACGTGCTCACCATGCTGGATGAGGCCTATATTCAGCCACAG
CCTCTGGGAGTGGTGCTGATAATCGGAGCTTGGAATTACCCCTTCGTTCTCACCATTCAG
CCACTGATAGGAGCCATCGCTGCAGGAAATGCTGTGATTATAAAGCCTTCTGAACTGAGT
GAAAATACAGCCAAGATCTTGGCAAAGCTTCTCCCTCAGTATTTAGACCAGGATCTCTAT
ATTGTTATTAATGGTGGTGTTGAGGAAACCACGGAGCTCCTGAAGCAGCGATTTGACCAC
ATTTTCTATACGGGAAACACTGCGGTTGGCAAAATTGTCATGGAAGCTGCTGCCAAGCAT
CTGACCCCTGTGACTCTTGAACTGGGAGGGAAAAGTCCATGTTATATTGATAAAGATTGT
GACCTGGACATTGTTTGCAGACGCATAACCTGGGGAAAATACATGAATTGTGGCCAAACC
TGCATTGCACCCGACTATATTCTCTGTGAAGCATCCCTCCAAAATCAAATTGTATGGAAG
ATTAAGGAAACAGTGAAGGAATTTTATGGAGAAAATATAAAAGAGTCTCCTGATTATGAA
AGGATCATCAATCTTCGTCATTTTAAGAGGATACTAAGTTTGCTTGAAGGACAAAAGATA
GCTTTTGGTGGGGAGACTGATGAGGCCACACGCTACATAGCCCCAACAGTACTTACCGAT
GTTGATCCTAAAACCAAGGTGATGCAAGAAGAAATTTTTGGACCAATTCTTCCAATAGTG
CCTGTGAAAAATGTAGATGAGGCCATAAATTTCATAAATGAACGTGAAAAGCCTCTGGCT
CTTTATGTATTTTCGCATAACCATAAGCTCATCAAACGGATGATTGATGAGACATCCAGT
GGAGGTGTCACAGGCAATGACGTCATTATGCACTTCACGCTCAACTCTTTCCCATTTGGA
GGAGTGGGTTCCAGTGGGATGGGAGCTTATCACGGAAAACATAGTTTTGATACTTTTTCT
CATCAGCGTCCCTGTTTATTAAAAAGTTTAAAGAGAGAAGGTGCTAACAAACTCAGATAT
CCTCCCAACAGCCAGTCAAAGGTGGATTGGGGGAAATTTTTTCTCTTGAAACGGTTCAAC
AAAGAAAAACTCGGTCTCCTGTTGCTCACTTTCCTGGGTATTGTAGCCGCTGTGCTTGTC
AAGGCAGAATATTACTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
L47162

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_4_Locus:
17p11.2

# Metabolic_Enzyme_4_SNPs:
rs7216; rs7503517; rs7215; rs16420; rs11204408; rs3786038; rs962801; rs2072333; rs1034897; rs2072331; rs2108971; rs1004490; rs1004491; rs4244600; rs962800; rs8069576; rs4925036; rs2072332; rs16960280; rs4646797; rs8069478; rs2386145; rs1800869; rs11204407; rs4646798; rs4646794; rs4925038; rs4646800; rs4925037; rs4646795; rs4646804; rs4646802; rs8073767; rs12937946; rs9910300; rs4646801; rs9901895; rs1034896; rs3760489; rs4621031; rs3888642; rs1057405; rs11548343; rs12947169; rs34160909; rs35364675; rs7209322; rs35495378; rs12947168; rs12708; rs4646805; rs7215552; rs35965955; rs2386146; rs35716578; rs34082599; rs4646799; rs4646796; rs3034928; rs1800870; rs35581449; rs5819686; rs34567842; rs34350257; rs34642385; rs4646793; rs11652177; rs4646907; rs34471504; rs8073053; rs2386147; rs6146012; rs34945824; rs36031953; rs34327718; rs35797108; rs34664206; rs4646803; rs35265843; rs36025724; rs35053333; rs3841513; rs34368630; rs4646806; rs35604266; rs16960266; rs28375263; rs11868363; rs11871420; rs11871642; rs12937179; rs1804608; rs2386144; rs34399035; rs34416664; rs35526408; rs4646807; rs4925026; rs8065688; rs8074204; rs8074500

# Metabolic_Enzyme_4_General_References:
8528251; 9027499; 9070922; 9254849; 9829906

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5526

# Metabolic_Enzyme_5_Name:
4-trimethylaminobutyraldehyde dehydrogenase

# Metabolic_Enzyme_5_Synonyms:
TMABADH; Aldehyde dehydrogenase 9A1; Aldehyde dehydrogenase E3 isozyme; Gamma-aminobutyraldehyde dehydrogenase; R- aminobutyraldehyde dehydrogenase

# Metabolic_Enzyme_5_Gene_Name:
ALDH9A1

# Metabolic_Enzyme_5_Protein_Sequence:
>4trimethylaminobutyraldehyde dehydrogenase
MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA
AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY
AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK
PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI
MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI
LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY
VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA
AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL
KTVCVEMGDVESAF

# Metabolic_Enzyme_5_Number_of_Residues:
494

# Metabolic_Enzyme_5_Molecular_Weight:
53802

# Metabolic_Enzyme_5_Theoretical_pI:
5.61

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_5_Specific_Function:
Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction

# Metabolic_Enzyme_5_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_5_Reaction:
4-trimethylammoniobutanal + NAD+ = 4-trimethylammoniobutanoate + NADH + H+

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.2.1.47;EC 1.2.1.3;EC

# Metabolic_Enzyme_5_GenBank_ID_Protein:
1049219

# Metabolic_Enzyme_5_SwissProt_ID:
AL9A1_HUMAN (P49189)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ALDH9A1

# Metabolic_Enzyme_5_Geneatlas_id:
ALDH9A1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:412

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1482 bp
ATGAGCACTGGCACCTTCGTCGTGTCGCAGCCGCTCAATTACCGCGGCGGGGCCGCTGGA
GCCGGCGGACGCTCCGGTACCGAGAAAGCTTTCGAGCCAGCAACCGGCCGAGTGATAGCT
ACTTTCACATGTTCAGGAGAAAAGGAAGTAAATTTGGCTGTTCAAAATGCAAAGGCTGCT
TTTAAAATATGGAGTCAAAAATCTGGCATGGAGCGTTGCCGAATCCTTTTGGAGGCTGCC
AGGATAATAAGGGAACGGGAGGATGAAATTGCTACTATGGAGTGCATCAACAATGGCAAG
TCCATCTTTGAGGCCCGCTTGGACATTGACATTTCCTGGCAGTGCCTGGAGTATTATGCG
GGCTTGGCTGCATCCATGGCTGGTGAACACATCCAGCTCCCAGGTGGATCGTTTGGTTAT
ACCAGAAGAGAACCACTTGGGGTATGTGTGGGAATAGGAGCATGGAACTACCCCTTTCAG
ATTGCCTCTTGGAAGTCGGCTCCAGCATTAGCCTGTGGTAATGCCATGGTCTTTAAACCT
TCTCCCTTTACACCTGTTTCTGCATTGCTACTGGCTGAAATCTACAGTGAGGCTGGTGTA
CCTCCTGGGCTCTTCAATGTGGTGCAGGGAGGGGCTGCCACAGGCCAGTTTCTGTGTCAG
CATCCCGATGTGGCCAAAGTCTCCTTCACTGGAAGTGTGCCCACTGGCATGAAGATCATG
GAGATGTCAGCTAAAGGAATCAAACCTGTTACCTTGGAACTTGGAGGCAAATCTCCACTC
ATCATCTTCTCAGACTGTGATATGAACAATGCTGTAAAGGGGGCGCTGATGGCCAACTTC
CTCACACAAGGCCAGGTTTGCTGTAATGGCACAAGAGTATTTGTGCAGAAAGAAATTCTT
GATAAATTTACAGAGGAAGTGGTGAAACAGACCCAAAGGATTAAAATTGGAGATCCCCTT
CTGGAAGATACAAGGATGGGTCCACTCATCAACCGACCACACCTGGAGCGAGTCCTTGGG
TTTGTCAAAGTGGCAAAGGAGCAGGGTGCTAAAGTGTTATGTGGTGGAGATATATATGTA
CCTGAAGATCCCAAATTAAAGGATGGATATTACATGAGACCTTGTGTATTAACTAATTGC
AGAGACGACATGACCTGTGTGAAGGAAGAGATCTTTGGGCCTGTTATGTCCATTTTATCA
TTTGACACTGAAGCTGAGGTTCTAGAAAGAGCCAATGATACCACTTTTGGACTAGCAGCT
GGCGTCTTTACCAGGGACATCCAACGGGCTCATAGAGTGGTAGCTGAGCTTCAGGCTGGG
ACGTGCTTCATTAACAACTATAACGTCAGCCCAGTGGAGTTGCCCTTTGGTGGATATAAG
AAGTCAGGATTTGGCAGAGAGAACGGCCGTGTGACAATCGAATATTATTCACAGCTGAAG
ACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U34252

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_5_Locus:
1q23.1

# Metabolic_Enzyme_5_SNPs:
rs1065756; rs11808728; rs1143659; rs11506; rs12670; rs12408101; rs1913844; rs2882006; rs10753688; rs4646891; rs4646889; rs7516126; rs12565874; rs3820362; rs10800129; rs10800128; rs7534437; rs12072634; rs4656457; rs1337442; rs2348728; rs4578194; rs12080699; rs7541817; rs10918239; rs2348727; rs3738192; rs6683969; rs12065621; rs2348734; rs16849230; rs6426930; rs12083232; rs7513998; rs12122497; rs7555787; rs4646886; rs10800127; rs10918252; rs2348729; rs4646883; rs7518869; rs10800133; rs2176151; rs4646882; rs1538115; rs10800131; rs4646897; rs6690818; rs2050619; rs10753689; rs7546084; rs12076579; rs17482717; rs4657463; rs10918235; rs11587760; rs4274037; rs12567331; rs4557947; rs1337443; rs10800130; rs10800132; rs4646895; rs16849238; rs17450889; rs12033254; rs12069198; rs6657651; rs10918245; rs3845537; rs10918237; rs11807857; rs11807866; rs884121; rs4657462; rs10918236; rs7543204; rs2184918; rs12070650; rs17417191; rs9970857; rs6662419; rs7367737; rs10918242; rs10918241; rs7546322; rs4646888; rs16849374; rs12409168; rs12037790; rs10918247; rs7537071; rs12084748; rs10918238; rs7368130; rs2348730; rs10918244; rs4233407; rs12123278; rs4646892; rs4657466; rs4576644; rs6683651; rs6667075; rs12021795; rs6683665; rs12081464; rs7546215; rs7519162; rs10918240; rs6667088; rs6669697; rs12081903; rs4646885; rs7542184; rs16849479; rs4646887; rs12072664; rs10753687; rs4646896; rs10157944; rs6668102; rs3753893; rs4657468; rs3753892; rs7553712; rs7511691; rs7554409; rs7544840; rs6426928; rs6667681; rs4646881; rs1415503; rs11555775; rs9164; rs4646902; rs6667510; rs11555774; rs4307543; rs11436915; rs34948330; rs12139219; rs34495301; rs10918248; rs1890080; rs35894201; rs4646884; rs28759374; rs12137604; rs28589393; rs34662022; rs12354157; rs10918246; rs35087657; rs34105906; rs35913333; rs34664103; rs12083492; rs2271658; rs34872122; rs7512816; rs4646893; rs7527514; rs12566251; rs1970286; rs3831954; rs2348731; rs10918249; rs35178491; rs36027739; rs35864611; rs17416948; rs4646894; rs11583089; rs12742656; rs12754903; rs12742657; rs41267568; rs4646890; rs12084651; rs4646900; rs34304173; rs13376536; rs12727801; rs41326750; rs28439296; rs12134617; rs12036561; rs35531113; rs3845536; rs36011778; rs12090132; rs7525102; rs10918250; rs3738191; rs12239517; rs4646898; rs34072474; rs34945812; rs10918251; rs1890079; rs35439339; rs36150573; rs1577847; rs12728137; rs34846458; rs4646901; rs36110991; rs12083091; rs34894576; rs6426927; rs11458950; rs1856143; rs35757606; rs41267564; rs41267566; rs35742388; rs10494446; rs10494447; rs10800123; rs10800125; rs10800126; rs10800135; rs10800136; rs10918228; rs10918229; rs10918231; rs10918254; rs10918255; rs10918256; rs11579160; rs11800476; rs11810856; rs12027066; rs12028588; rs12043815; rs12044709; rs12060366; rs12143472; rs12748251; rs1547725; rs16848876; rs16848958; rs16849041; rs16849616; rs1878074; rs1878075; rs2090281; rs2297762; rs2297763; rs2297764; rs2297765; rs3753894; rs3795540; rs4147602; rs4147604; rs4147605; rs4147610; rs4147611; rs4341347; rs7527279; rs7549511; rs7551594; rs8133; rs9333483; rs9333487; rs9919190

# Metabolic_Enzyme_5_General_References:
8786138; 10702312; 8645224; 8269919; 2925663

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5527

# Metabolic_Enzyme_6_Name:
Aldehyde dehydrogenase, dimeric NADP-preferring

# Metabolic_Enzyme_6_Synonyms:
ALDH class 3; ALDHIII

# Metabolic_Enzyme_6_Gene_Name:
ALDH3A1

# Metabolic_Enzyme_6_Protein_Sequence:
>Aldehyde dehydrogenase, dimeric NADPpreferring
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH

# Metabolic_Enzyme_6_Number_of_Residues:
453

# Metabolic_Enzyme_6_Molecular_Weight:
50380

# Metabolic_Enzyme_6_Theoretical_pI:
6.52

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_6_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes

# Metabolic_Enzyme_6_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_6_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_6_GenBank_ID_Protein:
178402

# Metabolic_Enzyme_6_SwissProt_ID:
AL3A1_HUMAN (P30838)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ALDH3A1

# Metabolic_Enzyme_6_Geneatlas_id:
ALDH3A1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:405

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_6_Gene_Sequence:
>1362 bp
ATGAGCAAGATCAGCGAGGCCGTGAAGCGCGCCCGCGCCGCCTTCAGCTCGGGCAGGACC
CGTCCGCTGCAGTTCCGATTCCAGCAGCTGGAGGCGCTGCAGCGCCTGATCCAGGAGCAG
GAGCAGGAGCTGGTGGGCGCGCTGGCCGCAGACCTGCACAAGAATGAATGGAACGCCTAC
TATGAGGAGGTGGTGTACGTCCTAGAGGAGATCGAGTACATGATCCAGAAGCTCCCTGAG
TGGGCCGCGGATGAGCCCGTGGAGAAGACGCCCCAGACTCAGCAGGACGAGCTCTACATC
CACTCGGAGCCACTGGGCGTGGTCCTCGTCATTGGCACCTGGAACTACCCCTTCAACCTC
ACCATCCAGCCCATGGTGGGCGCCATCGCTGCAGGGAACGCAGTGGTCCTCAAGCCCTCG
GAGCTGAGTGAGAACATGGCGAGCCTGCTGGCTACCATCATCCCCCAGTACCTGGACAAG
GATCTGTACCCAGTAATCAATGGGGGTGTCCCTGAGACCACGGAGCTGCTCAAGGAGAGG
TTCGACCATATCCTGTACACGGGCAGCACGGGGGTGGGGAAGATCATCATGACGGCTGCT
GCCAAGCACCTGACCCCTGTCACGCTGGAGCTGGGAGGGAAGAGTCCCTGCTACGTGGAC
AAGAACTGTGACCTGGACGTGGCCTGCCGACGCATCGCCTGGGGGAAATTCATGAACAGT
GGCCAGACCTGCGTGGCCCCAGACTACATCCTCTGTGACCCCTCGATCCAGAACCAAATT
GTGGAGAAGCTCAAGAAGTCACTGAAAGAGTTCTACGGGGAAGATGCTAAGAAATCCCGG
GACTATGGAAGAATCATTAGTGCCCGGCACTTCCAGAGGGTGATGGGCCTGATTGAGGGC
CAGAAGGTGGCTTATGGGGGCACCGGGGATGCCGCCACTCGCTACATAGCCCCCACCATC
CTCACGGACGTGGACCCCCAGTCCCCGGTGATGCAAGAGGAGATCTTCGGGCCTGTGCTG
CCCATCGTGTGCGTGCGCAGCCTGGAGGAGGCCATCCAGTTCATCAACCAGCGTGAGAAG
CCCCTGGCCCTCTACATGTTCTCCAGCAACGACAAGGTGATTAAGAAGATGATTGCAGAG
ACATCCAGTGGTGGGGTGGCGGCCAACGATGTCATCGTCCACATCACCTTGCACTCTCTG
CCCTTCGGGGGCGTGGGGAACAGCGGCATGGGATCCTACCATGGCAAGAAGAGCTTCGAG
ACTTTCTCTCACCGCCGCTCTTGCCTGGTGAGGCCTCTGATGAATGATGAAGGCCTGAAG
GTCAGATACCCCCCGAGCCCGGCCAAGATGACCCAGCACTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M74542

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_6_Locus:
17p11.2

# Metabolic_Enzyme_6_SNPs:
rs887241; rs2228100; rs3744692; rs2072330; rs4646787; rs1042183; rs917520; rs4646789; rs4646788; rs3786036; rs887240; rs2072329; rs4646790; rs3744693; rs9895030; rs3826507; rs3744695; rs3744694; rs2072328; rs1006556; rs4319825; rs1042172; rs11554977; rs11554978; rs11554975; rs11554974; rs34474118; rs3786037; rs35473971; rs4646792; rs35116940; rs4646791; rs35853488; rs887239; rs28531080; rs7216299; rs35009373; rs3786035; rs11385990; rs35308039; rs35128135; rs35885485; rs28552545; rs34438543; rs1006553; rs11650088; rs11651480; rs11870332; rs12948881; rs12949049; rs12951039; rs16960382; rs16960386; rs17793620; rs1989379; rs2016823; rs2052052; rs2072327; rs2108967; rs3760485; rs3760486; rs3760487; rs4646783; rs4646784; rs4646785; rs4646786; rs4924793; rs4925046; rs7214841; rs7221211; rs7225305; rs8075157; rs9898715; rs9900430

# Metabolic_Enzyme_6_General_References:
1737758; 8493892; 2037078; 9250352

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5529

# Metabolic_Enzyme_7_Name:
Aldehyde dehydrogenase 1A3

# Metabolic_Enzyme_7_Synonyms:
Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3

# Metabolic_Enzyme_7_Gene_Name:
ALDH1A3

# Metabolic_Enzyme_7_Protein_Sequence:
>Aldehyde dehydrogenase 1A3
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI
CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM
DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW
NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV
GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE
CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK
QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL
KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF
KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP

# Metabolic_Enzyme_7_Number_of_Residues:
512

# Metabolic_Enzyme_7_Molecular_Weight:
56109

# Metabolic_Enzyme_7_Theoretical_pI:
7.29

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_7_Specific_Function:
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system

# Metabolic_Enzyme_7_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_7_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_7_GenBank_ID_Protein:
544482

# Metabolic_Enzyme_7_SwissProt_ID:
AL1A3_HUMAN (P47895)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
ALDH1A3

# Metabolic_Enzyme_7_Geneatlas_id:
ALDH1A3

# Metabolic_Enzyme_7_hgnc_id:
HGNC:409

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_7_Gene_Sequence:
>1539 bp
ATGGCCACCGCTAACGGGGCCGTGGAAAACGGGCAGCCGGACGGGAAGCCGCCGGCCCTG
CCGCGCCCCATCCGCAACCTGGAGGTCAAGTTCACCAAGATATTTATCAACAATGAATGG
CACGAATCCAAGAGTGGGAAAAAGTTTGCTACATGTAACCCTTCAACTCGGGAGCAAATA
TGTGAAGTGGAAGAAGGAGATAAGCCCGACGTGGACAAGGCTGTGGAGGCTGCACAGGTT
GCCTTCCAGAGGGGCTCGCCATGGCGCCGGCTGGATGCCCTGAGTCGTGGGCGGCTGCTG
CACCAGCTGGCTGACCTGGTGGAGAGGGACCGCGCCACCTTGGCCGCCCTGGAGACGATG
GATACAGGGAAGCCATTTCTTCATGCTTTTTTCATCGACCTGGAGGGCTGTATTAGAACC
CTCAGATACTTTGCAGGGTGGGCAGACAAAATCCAGGGCAAGACCATCCCCACAGATGAC
AACGTCGTATGCTTCACCAGGCATGAGCCCATTGGTGTCTGTGGGGCCATCACTCCATGG
AACTTCCCCCTGCTGATGCTGGTGTGGAAGCTGGCACCCGCCCTCTGCTGTGGGAACACC
ATGGTCCTGAAGCCTGCGGAGCAGACACCTCTCACCGCCCTTTATCTCGGCTCTCTGATC
AAAGAGGCCGGGTTCCCTCCAGGAGTGGTGAACATTGTGCCAGGATTCGGGCCCACAGTG
GGAGCAGCAATTTCTTCTCACCCTCAGATCAACAAGATCGCCTTCACCGGCTCCACAGAG
GTTGGAAAACTGGTTAAAGAAGCTGCGTCCCGGAGCAATCTGAAGCGGGTGACGCTGGAG
CTGGGGGGGAAGAACCCCTGCATCGTGTGTGCGGACGCTGACTTGGACTTGGCAGTGGAG
TGTGCCCATCAGGGAGTGTTCTTCAACCAAGGCCAGTGTTGCACGGCAGCCTCCAGGGTG
TTCGTGGAGGAGCAGGTCTACTCTGAGTTTGTCAGGCGGAGCGTGGAGTATGCCAAGAAA
CGGCCCGTGGGAGACCCCTTCGATGTCAAAACAGAACAGGGGCCTCAGATTGATCAAAAG
CAGTTCGACAAAATCTTAGAGCTGATCGAGAGTGGGAAGAAGGAAGGGGCCAAGCTGGAA
TGCGGGGGCTCAGCCATGGAAGACAAGGGGCTCTTCATCAAACCCACTGTCTTCTCAGAA
GTCACAGACAACATGCGGATTGCCAAAGAGGAGATTTTCGGGCCAGTGCAACCAATACTG
AAGTTCAAAAGTATCGAAGAAGTGATAAAAAGAGCGAATAGCACCGACTATGGACTCACA
GCAGCCGTGTTCACAAAAAATCTCGACAAAGCCCTGAAGTTGGCTTCTGCCTTAGAGTCT
GGAACGGTCTGGATCAACTGCTACAACGCCCTCTATGCACAGGCTCCATTTGGTGGCTTT
AAAATGTCAGGAAATGGCAGAGAACTAGGTGAATACGCTTTGGCCGAATACACAGAAGTG
AAAACTGTCACCATCAAACTTGGCGACAAGAACCCCTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
U07919

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_7_Locus:
15q26.3

# Metabolic_Enzyme_7_SNPs:
rs3803430; rs2229183; rs1130738; rs14226; rs3803424; rs7045; rs3803426; rs7182089; rs4646690; rs7161860; rs4246328; rs4646688; rs4646668; rs4646670; rs3803428; rs4646671; rs6598396; rs4646675; rs9944290; rs7181897; rs4646684; rs4246323; rs4246327; rs4246329; rs4646674; rs8039374; rs4646678; rs4646653; rs4646655; rs7182884; rs3809521; rs11854028; rs3825926; rs3803433; rs6598397; rs4646662; rs4646685; rs4646651; rs4646672; rs3922685; rs4646654; rs3902902; rs4646683; rs7176046; rs3803432; rs4246324; rs4646661; rs8030776; rs12903828; rs4646687; rs4646680; rs3825925; rs7178221; rs3803427; rs7170197; rs4246325; rs8023972; rs4646681; rs7167278; rs4246326; rs1886; rs4646649; rs12908902; rs7171776; rs3803429; rs12914598; rs4646669; rs4646650; rs3803434; rs4646660; rs4646682; rs3809524; rs3809523; rs3809526; rs7179268; rs1130737; rs3803431; rs1130768; rs34302490; rs28760343; rs35300460; rs1802602; rs1802604; rs4288979; rs3803425; rs1802603; rs4646663; rs28691047; rs28731371; rs34655770; rs35165034; rs28509297; rs10400871; rs35129664; rs12905372; rs28405557; rs34486175; rs28546254; rs35055541; rs4646686; rs28441320; rs28410143; rs4646676; rs4646648; rs8029933; rs12910188; rs34182689; rs28504296; rs28449981; rs28507582; rs3825927; rs35310246; rs12910025; rs28384196; rs4343265; rs12910662; rs8028283; rs28475530; rs4392045; rs28369514; rs28377287; rs8035722; rs28480133; rs28707102; rs28583888; rs4646666; rs7173413; rs28472416; rs28673034; rs28668881; rs28711429; rs34837038; rs4646659; rs28452487; rs28712665; rs12910029; rs12902704; rs4646673; rs28689536; rs28431101; rs34431941; rs7178645; rs28454526; rs7170202; rs1889; rs4646647; rs4375646; rs11348272; rs4646656; rs28408085; rs28699556; rs28615197; rs28539744; rs28557216; rs28631565; rs34302839; rs3923499; rs4646664; rs35740226; rs28385499; rs3922686; rs28474807; rs28490217; rs12909825; rs10593974; rs28679806; rs28610999; rs7178553; rs35519561; rs35831758; rs35526807; rs4646658; rs28538652; rs28685242; rs10400842; rs4646667; rs35948146; rs4646677; rs7165217; rs10400872; rs28750207; rs3825924; rs7171453; rs34906846; rs4646665; rs9920154; rs36081993; rs11435500; rs28464660; rs4646679; rs12595234; rs4646689; rs3809522; rs35950557; rs3809527; rs7172149; rs7178931; rs8034153; rs7183889; rs3809525; rs4646646; rs11630601; rs11630691; rs11632820; rs11637204; rs11854709; rs12148466; rs12148493; rs12440023; rs12593839; rs12901792; rs12907776; rs12908105; rs12909230; rs12909791; rs28507591; rs3803435; rs4346184; rs4646694; rs7163108; rs7164136; rs7181644; rs8034686; rs8035036

# Metabolic_Enzyme_7_General_References:
7698756

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5530

# Metabolic_Enzyme_8_Name:
Aldehyde dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_8_Synonyms:
ALDH class 2; ALDHI; ALDH-E2

# Metabolic_Enzyme_8_Gene_Name:
ALDH2

# Metabolic_Enzyme_8_Protein_Sequence:
>Aldehyde dehydrogenase, mitochondrial precursor
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS

# Metabolic_Enzyme_8_Number_of_Residues:
517

# Metabolic_Enzyme_8_Molecular_Weight:
56382

# Metabolic_Enzyme_8_Theoretical_pI:
7.05

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_8_Specific_Function:
An aldehyde + NAD(+) + H(2)O = an acid + NADH

# Metabolic_Enzyme_8_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_8_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_8_Signals:
1-24

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_8_GenBank_ID_Protein:
28606

# Metabolic_Enzyme_8_SwissProt_ID:
ALDH2_HUMAN (P05091)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
ALDH2

# Metabolic_Enzyme_8_Geneatlas_id:
ALDH2

# Metabolic_Enzyme_8_hgnc_id:
HGNC:404

# Metabolic_Enzyme_8_PDB_ID:
1OF7

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_8_Gene_Sequence:
>1551 bp
ATGTTGCGCGCTGCCGCCGCTCGGGCCCCGCCTGGCCGCCGCCTCTTGTCAGCCGCCGCC
ACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTTCATA
AACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACT
GGAGAGGTCATCTGTCAGGTAGCTGAAGGGGACAAGGAAGATGTGGACAAGGCACGTGAA
GGCCGCCCGGGCGCCTTCCAGCTGGGCTCACCTTGGCGCCGCATGGACGCATCACACAGC
GGCCGGCTGCTGAACCGCCTGGCCGATCTGATCGAGCGGGACCGGACCTACCTGGCGGCC
TTGGAGACCCTGGACAATGGCAAGCCCTATGTCATCTCCTACCTGGTGGATTTGGACATG
GTCCTCAAATGTCTCCGGTATTATGCCGGCTGGGCTGATAAGTACCACGGGAAAACCATC
CCCATTGACGGAGACTTCTTCAGCTACACACGCCATGAACCTGTGGGGGTGTGCGGGCAG
ATCATTCCGTGGAATTTCCCGCTCCTGATGCAAGCATGGAAGCTGGGCCCAGCCTTGGCA
ACTGGAAACGTGGTTGTGATGAAGGTAGCTGAGCAGACACCCCTCACCGCCCTCTATGTG
GCCAACCTGATCAAGGAGGCTGGCTTTCCCCCTGGTGTGGTCAACATTGTGCCTGGATTT
GGCCCCACGGCTGGGGCCGCCATTGCCTCCCATGAGGATGTGGACAAAGTGGCATTCACA
GGCTCCACTGAGATTGGCCGCGTAATCCAGGTTGCTGCTGGGAGCAGCAACCTCAAGAGA
GTGACCTTGGAGCTGGGGGGGAAGAGCCCCAACATCATCATGTCAGATGCCGATATGGAT
TGGGCCGTGGAACAGGCCCACTTCGCCCTGTTCTTCAACCAGGGCCAGTGCTGCTGTGCC
GGCTCCCGGACCTTCGTGCAGGAGGACATCTATGATGAGTTTGTGGTGCGGAGCGTTGCC
CGGGCCAAGTCTCGGGTGGTCGGGAACCCCTTTGATAGCAAGACCGAGCAGGGGCCGCAG
GTGGATGAAACTCAGTTTAAGAAGATCCTCGGCTACATCAACACGGGGAAGCAAGAGGGG
GCGAAGCTGCTGTGTGGTGGGGGCATTGCTGCTGACCGTGGTTACTTCATCCAGCCCACT
GTGTTTGGAGATGTGCAGGATGGCATGACCATCGCCAAGGAGGAGATCTTCGGGCCAGTG
ATGCAGATCCTGAAGTTCAAGACCATAGAGGAGGTTGTTGGGAGAGCCAACAATTCCACG
TACGGGCTGGCCGCAGCTGTCTTCACAAAGGATTTGGACAAGGCCAATTACCTGTCCCAG
GCCCTCCAGGCGGGCACTGTGTGGGTCAACTGCTATGATGTGTTTGGAGCCCAGTCACCC
TTTGGTGGCTACAAGATGTCGGGGAGTGGCCGGGAGTTGGGCGAGTACGGGCTGCAGGCA
TACACTGAAGTGAAAACTGTCACAGTCAAAGTGCCTCAGAAGAACTCATAA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X05409

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_8_Locus:
12q24.2

# Metabolic_Enzyme_8_SNPs:
rs671; rs1062136; rs6490301; rs886205; rs2238151; rs968529; rs7296651; rs441; rs4767939; rs10744777; rs4646778; rs4767944; rs10849970; rs2158029; rs4646776; rs7312055; rs7311852; rs2238152; rs4646777; rs2283354; rs10774637; rs4648328; rs10774638; rs11609628; rs11066028; rs4646779; rs16941669; rs440; rs7397491; rs11834780; rs16941667; rs4646775; rs11066029; rs35154896; rs11066024; rs2106696; rs11613231; rs2158028; rs4767035; rs13306166; rs34083959; rs7136890; rs13306164; rs1064933; rs34477327; rs34884061; rs28633753; rs11442381; rs11615695; rs11066023; rs35511855; rs35781311; rs13306163; rs7397456; rs35050853; rs35642129; rs12312867; rs12829533; rs11407827; rs34480430; rs12314397; rs35264878; rs12813835; rs12322000; rs34896918; rs35650885; rs7970477; rs11066025; rs13306167; rs11066027; rs12301347; rs11614684; rs35700215; rs35746295; rs34587287; rs13306165; rs35786282; rs11066022; rs7397469; rs11066030; rs10450717; rs35693865; rs11503169; rs35546929; rs33973376; rs34497874; rs12830829; rs35061167; rs11609093; rs36073646; rs34108639; rs12824249; rs11610258; rs35147079; rs11613713; rs11066026; rs7486832; rs12099590; rs3832868; rs34300515; rs35212101; rs7398472; rs35239056; rs35752199; rs5800933; rs11613351; rs5023470; rs34587619; rs4646781; rs4646780; rs11304348; rs12305979; rs4646782; rs10849969; rs10849971; rs11066032; rs14630; rs2339839; rs2339840; rs7133964; rs737280; rs739580; rs7974339; rs7978737; rs9971942

# Metabolic_Enzyme_8_General_References:
3582651; 3562250; 2838413; 4065146; 2987944; 4015823; 3610592; 3653404; 6582480; 8561277; 10631996

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5968

# Metabolic_Enzyme_9_Name:
Glyceraldehyde-3-phosphate dehydrogenase

# Metabolic_Enzyme_9_Synonyms:
GAPDH

# Metabolic_Enzyme_9_Gene_Name:
GAPDH

# Metabolic_Enzyme_9_Protein_Sequence:
>Glyceraldehyde3phosphate dehydrogenase
MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTV
KAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVI
ISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHA
ITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANV
SVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAG
IALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE

# Metabolic_Enzyme_9_Number_of_Residues:
335

# Metabolic_Enzyme_9_Molecular_Weight:
36054

# Metabolic_Enzyme_9_Theoretical_pI:
8.73

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Function:  glyceraldehyde-3-phosphate dehydrogenase activity
Function:  glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH

# Metabolic_Enzyme_9_Pathway:
map00010  Glycolysis / Gluconeogenesis

# Metabolic_Enzyme_9_Reaction:
D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF02800:Gp_dh_C;
PF00044:Gp_dh_N

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 1.2.1.12

# Metabolic_Enzyme_9_GenBank_ID_Protein:
31645

# Metabolic_Enzyme_9_SwissProt_ID:
G3P_HUMAN (P04406)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
GAPDH

# Metabolic_Enzyme_9_Geneatlas_id:
GAPDH

# Metabolic_Enzyme_9_hgnc_id:
HGNC:4141

# Metabolic_Enzyme_9_PDB_ID:
1J0X

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_9_Gene_Sequence:
>1008 bp
ATGGGGAAGGTGAAGGTCGGAGTCAACGGATTTGGTCGTATTGGGCGCCTGGTCACCAGG
GCTGCTTTTAACTCTGGTAAAGTGGATATTGTTGCCATCAATGACCCCTTCATTGACCTC
AACTACATGGTTTACATGTTCCAATATGATTCCACCCATGGCAAATTCCATGGCACCGTC
AAGGCTGAGAACGGGAAGCTTGTCATCAATGGAAATCCCATCACCATCTTCCAGGAGCGA
GATCCCTCCAAAATCAAGTGGGGCGATGCTGGCGCTGAGTACGTCGTGGAGTCCACTGGC
GTCTTCACCACCATGGAGAAGGCTGGGGCTCATTTGCAGGGGGGAGCCAAAAGGGTCATC
ATCTCTGCCCCCTCTGCTGATGCCCCCATGTTCGTCATGGGTGTGAACCATGAGAAGTAT
GACAACAGCCTCAAGATCATCAGCAATGCCTCCTGCACCACCAACTGCTTAGCACCCCTG
GCCAAGGTCATCCATGACAACTTTGGTATCGTGGAAGGACTCATGACCACAGTCCATGCC
ATCACTGCCACCCAGAAGACTGTGGATGGCCCCTCCGGGAAACTGTGGCGTGATGGCCGC
GGGGCTCTCCAGAACATCATCCCTGCCTCTACTGGCGCTGCCAAGGCTGTGGGCAAGGTC
ATCCCTGAGCTAGACGGGAAGCTCACTGGCATGGCCTTCCGTGTCCCCACTGCCAACGTG
TCAGTGGTGGACCTGACCTGCCGTCTAGAAAAACCTGCCAAATATGATGACATCAAGAAG
GTGGTGAAGCAGGCGTCGGAGGGCCCCCTCAAAGGCATCCTGGGCTACACTGAGCACCAG
GTGGTCTCCTCTGACTTCAACAGCGACACCCACTCCTCCACCTTTGACGCTGGGGCTGGC
ATTGCCCTCAACGACCACTTTGTCAAGCTCATTTCCTGGTATGACAACGAATTTGGCTAC
AGCAACAGGGTGGTGGACCTCATGGCCCACATGGCCTCCAAGGAGTAA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
X01677

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_9_Locus:
12p13

# Metabolic_Enzyme_9_SNPs:
rs1803621; rs1065691; rs1803622; rs1136666; rs3741918; rs3741917; rs1060619; rs1060620; rs1060621; rs2886093; rs41334949; rs7971637; rs6489721; rs11549346; rs11549333; rs11549340; rs1065740; rs11549329; rs11549351; rs11549345; rs1062442; rs3211600; rs1803625; rs1062429; rs1062436; rs11549361; rs11549327; rs11549316; rs11549338; rs11549348; rs11549373; rs11549343; rs11549336; rs11549325; rs11549350; rs11549371; rs11549355; rs3203507; rs11549347; rs11266742; rs11549318; rs3211592; rs11549319; rs3199979; rs11549332; rs3741915; rs11549320; rs3211599; rs3211598; rs11552253; rs35318117; rs35043201; rs3759342; rs36015908; rs34277306; rs12425927; rs7307229; rs7977806; rs36094914; rs1043262; rs1047792; rs1063206; rs10849482; rs10849483; rs10849484; rs10849485; rs10849488; rs11064250; rs16932751; rs2072374; rs2240871; rs2240875; rs2270176; rs2270177; rs35819349; rs7132183; rs7297283; rs7300366; rs7311174; rs7316224; rs733593; rs740850; rs740851; rs740852; rs758740; rs7979706

# Metabolic_Enzyme_9_General_References:
6096136; 6096821; 2987855; 3664468; 3027061; 3170585; 1924305; 10944468; 7030790; 12665801; 7498159; 1193541; 957435

# Metabolic_Enzyme_9_References:
14622286; 7827041

# Macromolecular_Interacting_Partner_1_ID:
8150

# Macromolecular_Interacting_Partner_1_Name:
LP5910 protein

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>LP5910 protein
MQGDVKSMAQFYGLLAHVARTRLTPSMAGASVEEDAQLHELAAELQIPDLQLEEALETMA
WGRGPVCLLAGGEPTVQLQGSGRGGRNQELALRVGAELRRWPLGPIDVLFLSGGTDGQDG
PTEAAGAWVTPELASQAAAEGLDIATFLAHNDSHTFFCCLQGGAHLLHTGMTGTNVMDTH
LLFLRPR

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
187

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
19868

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
4.68

# Macromolecular_Interacting_Partner_1_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF05161:MOFRL

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
37779142

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
Q6Y2K6_HUMAN (Q6Y2K6)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_1_hgnc_id:
Not Available

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>564 bp
ATGCAAGGTGATGTAAAAAGTATGGCCCAGTTCTACGGGCTGCTGGCCCATGTGGCTAGA
ACCCGCCTCACCCCATCCATGGCTGGGGCTTCTGTGGAGGAAGATGCACAGCTCCATGAG
CTGGCAGCTGAGCTTCAGATCCCAGACCTGCAGCTGGAGGAGGCTCTGGAGACCATGGCA
TGGGGAAGGGGCCCAGTCTGCCTGCTGGCTGGTGGCGAGCCCACAGTACAGCTGCAGGGC
TCGGGCAGGGGTGGCCGGAACCAGGAACTGGCCCTGCGTGTTGGAGCAGAGTTGAGAAGG
TGGCCGCTGGGGCCGATAGATGTGCTGTTTTTGAGCGGTGGCACCGATGGGCAGGATGGG
CCCACAGAGGCTGCTGGGGCCTGGGTCACACCTGAGCTTGCCAGCCAGGCTGCAGCTGAG
GGCCTGGACATAGCCACCTTCCTAGCCCACAATGACTCACATACCTTCTTCTGCTGCCTC
CAGGGTGGGGCACACCTGCTGCACACAGGGATGACAGGTACCAATGTCATGGACACCCAC
CTCTTGTTCCTGCGGCCTCGGTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AY189286

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Locus:
Not Available

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
Not Available

# Macromolecular_Interacting_Partner_1_References:
16228612; 16664873

End of HMDB00139

Beginning of HMDB00140
# Accession_No:
HMDB00140

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-24 11:42:15

# biospider_lastupdate:
2007-07-26 09:32:19

# Common_Name:
Glucosylceramide

# Description:
A glycosphingolipid (ceramide and oligosaccharide)or oligoglycosylceramide with one or more sialic acids (i.e. n-acetylneuraminic acid) linked on the sugar chain. It is a component the cell plasma membrane which modulates cell signal transduction events. Gangliosides have been found to be highly important in immunology. Ganglioside GL1a carries a net-negative charge at pH 7.0 and is acidic. Gangliosides can amount to 6% of the weight of lipids from brain, but they are found at low levels in all animal tissues.

# Synonyms:
1-O-b-D-glucopyranosyl-Ceramide; Ganglioside GL1a; Gaucher cerebroside; GlcCeramide; Glucocerebroside; Glucosylceramide; Glc-beta1->1'Cer; 1-O-beta-delta-glucopyranosyl-Ceramide

# Chemical_IUPAC_Name:
N-[(E,2S,3R)-3-hydroxy-1-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadec-4-en-2-yl]tetracosanamide

# Chemical_Formula:
C48H93NO8

# Chemical_Structure:
tbl_chemical:::HMDB00140.gif:::118546398293715452

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00140.gif:::118546398321437285

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Glycosphingolipids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
acetal; primary alcohol; secondary alcohol; 1,2-diol; secondary carboxylic acid amide; alkene; heterocyclic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
811.69000

# Molecular_Weight_Avg:
812.25403

# Smiles_String_isomeric:
CCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)[C@@H](C=CCCCCCCCCCCCCC)O

# Smiles_String_canonical:
CCCCCCCCCCCCCCCCCCCCCCCC(=O)NC(COC1C(C(C(C(O1)CO)O)O)O)C(C=CCCCCCCCCCCCCC)O

# KEGG_Compound_ID:
C01190

# BioCyc_ID:
GLUCOSYL_CERAMIDE

# PubChem_CID:
6475228

# PubChem_SID:
628522; 4416; 24638312

# OMIM_ID:
602874

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Not Available

# METLIN_ID:
Not Available

# Ref_ID:
Not Available

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
85305-87-9

# InChI:
InChI=1/C48H93NO8/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-44(52)49-41(40-56-48-47(55)46(54)45(53)43(39-50)57-48)42(51)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2/h35,37,41-43,45-48,50-51,53-55H,3-34,36,38-40H2,1-2H3,(H,49,52)/b37-35+/t41-,42+,43+,45+,46-,47+,48+/m0/s1/f/h49H

# Synthesis_Reference:
Not Available

# Melting_Point:
Not Available

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
Insoluble [Technical Appendix B Physicochemical Properties for TRI Chemicals and Chemical]

# H2O_Solubility_Predicted:
1.86e-04 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
9.15 [Predicted by ALOGPS]; 13.4 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00140.mol:::118546398317091725

# SDF_File_[Text]:
tbl_chemical:::HMDB00140.sdf:::11854639832233888

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00140.pdb:::118546398331012114

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
Not Available

# pred_hnmr_peaklist:
Not Available

# Predicted_C_NMR_Spectrum:
Not Available

# pred_cnmr_peaklist:
Not Available

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane

# Tissue_Location:
Brain; Nerve Cells

# deuterated:
No

# Biofluid_Location:
Blood

# Concentration_[Normal]:
Blood	6.0 +/- 2.0	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Cystic Kidney; Farber Disease; Gaucher Disease

# Pathway_Names:
Not Available

# Pathway_Images:
Not Available

# KEGG_Images:
Not Available

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7010

# Macromolecular_Interacting_Partner_1_Name:
Proactivator polypeptide precursor [Contains: Saposin A

# Macromolecular_Interacting_Partner_1_Synonyms:
Protein A; Saposin B-Val; Saposin B; Sphingolipid activator protein 1; SAP-1; Cerebroside sulfate activator; CSAct; Dispersin; Sulfatide/GM1 activator; Saposin C; Co-beta-glucosidase; A1 activator; Glucosylceramidase activator; Sphingolipid activator protein 2; SAP-2; Saposin D; Protein C; Component C]

# Macromolecular_Interacting_Partner_1_Gene_Name:
PSAP

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Proactivator polypeptide precursor Contains: Saposin 
AMYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVK
SLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILD
IIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLL
YPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMAD
ICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELV
EPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQE
VVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYL
DRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKI
GACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
524

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
58113

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
4.82

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  sphingolipid metabolism
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  vacuole
Component:  lytic vacuole
Component:  lysosome

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Saposin D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12)

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF02199:SapA;
PF05184:SapB_1;
PF03489:SapB_2

# Macromolecular_Interacting_Partner_1_Signals:
1-16

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
220064

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
SAP_HUMAN (P07602)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
PSAP

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
PSAP

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9498

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Lysosome

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1584 bp
ATGTACGCCCTCTTCCTCCTGGCCAGCCTCCTGGGCGCGGCTCTAGCCGGCCCGGTCCTT
GGACTGAAAGAATGCACCAGGGGCTCGGCAGTGTGGTGCCAGAATGTGAAGACGGCGTCC
GACTGCGGGGCAGTGAAGCACTGCCTGCAGACCGTTTGGAACAAGCCAACAGTGAAATCC
CTTCCCTGCGACATATGCAAAGACGTTGTCACCGCAGCTGGTGATATGCTGAAGGACAAT
GCCACTGAGGAGGAGATCCTTGTTTACTTGGAGAAGACCTGTGACTGGCTTCCGAAACCG
AACATGTCTGCTTCATGCAAGGAGATAGTGGACTCCTACCTCCCTGTCATCCTGGACATC
ATTAAAGGAGAAATGAGCCGTCCTGGGGAGGTGTGCTCTGCTCTCAACCTCTGCGAGTCT
CTCCAGAAGCACCTAGCAGAGCTGAATCACCAGAAGCAGCTGGAGTCCAATAAGATCCCA
GAGCTGGACATGACTGAGGTGGTGGCCCCCTTCATGGCCAACATCCCTCTCCTCCTCTAC
CCTCAGGACGGCCCCCGCAGCAAGCCCCAGCCAAAGGATAATGGGGACGTTTGCCAGGAC
TGCATTCAGATGGTGACTGACATCCAGACTGCTGTACGGACCAACTCCACCTTTGTCCAG
GCCTTGGTGGAACATGTCAAGGAGGAGTGTGACCGCCTGGGCCCTGGCATGGCCGACATA
TGCAAGAACTATATCAGCCAGTATTCTGAAATTGCTATCCAGATGATGATGCACATGCAG
GATCAGCAACCCAAGGAGATCTGTGCGCTGGTTGGGTTCTGTGATGAGGTGAAAGAGATG
CCCATGCAGACTCTGGTCCCCGCCAAAGTGGCCTCCAAGAATGTCATCCCTGCCCTGGAA
CTGGTGGAGCCCATTAAGAAGCACGAGGTCCCAGCAAAGTCTGATGTTTACTGTGAGGTG
TGTGAATTCCTGGTGAAGGAGGTGACCAAGCTGATTGACAACAACAAGACTGAGAAAGAA
ATACTCGACGCTTTTGACAAAATGTGCTCGAAGCTGCCGAAGTCCCTGTCGGAAGAGTGC
CAGGAGGTGGTGGACACGTACGGCAGCTCCATCCTGTCCATCCTGCTGGAGGAGGTCAGC
CCTGAGCTGGTGTGCAGCATGCTGCACCTCTGCTCTGGCACGCGGCTGCCTGCACTGACC
GTTCACGTGACTCAGCCAAAGGACGGTGGCTTCTGCGAAGTGTGCAAGAAGCTGGTGGGT
TATTTGGATCGCAACCTGGAGAAAAACAGCACCAAGCAGGAGATCCTGGCTGCTCTTGAG
AAAGGCTGCAGCTTCCTGCCAGACCCTTACCAGAAGCAGTGTGATCAGTTTGTGGCAGAG
TACGAGCCCGTGCTGATCGAGATCCTGGTGGAGGTGATGGATCCTTCCTTCGTGTGCTTG
AAAATTGGAGCCTGCCCCTCGGCCCATAAGCCCTTGTTGGGAACTGAGAAGTGTATATGG
GGCCCAAGCTACTGGTGCCAGAACACAGAGACAGCAGCCCAGTGCAATGCTGTCGAGCAT
TGCAAACGCCATGTGTGGAACTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
D00422

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_1_Locus:
10q21-q22

# Macromolecular_Interacting_Partner_1_SNPs:
rs2070188; rs7869; rs1055754; rs2394846; rs762571; rs1015193; rs4237331; rs720295; rs7899959; rs7905774; rs7922255; rs885828; rs4237332; rs4747202; rs4747206; rs2070968; rs2394845; rs4747207; rs1900498; rs7350390; rs728289; rs2394844; rs6480560; rs9663508; rs2593163; rs749823; rs3747860; rs6480561; rs3819341; rs6480559; rs11000017; rs10740391; rs727414; rs2249814; rs2121535; rs7912803; rs2854986; rs7093252; rs10823852; rs3747855; rs11000020; rs16929408; rs11598989; rs11596365; rs4747203; rs12413995; rs10762483; rs4747204; rs4747208; rs11000016; rs12414356; rs2854992; rs11000025; rs727415; rs4747205; rs2166630; rs16913438; rs10762484; rs2854987; rs1900499; rs4454640; rs7917605; rs11000018; rs12413014; rs4746095; rs10762482; rs12415202; rs762573; rs12769743; rs1811087; rs2290023; rs7918049; rs11813373; rs9665661; rs11592448; rs9415055; rs11591470; rs7916568; rs7917015; rs11818931; rs2394843; rs11000019; rs4747209; rs7898293; rs4747210; rs11598617; rs9299509; rs9299510; rs12261323; rs1803650; rs11555015; rs11555016; rs11555021; rs11555017; rs1049882; rs1056711; rs1054851; rs1054293; rs11555018; rs41282246; rs11555020; rs36076120; rs14595; rs1053333; rs12844; rs28365839; rs1803651; rs2121536; rs7090110; rs11596605; rs35320964; rs34332602; rs2593164; rs11000024; rs7091271; rs9416009; rs2854984; rs5786051; rs34551152; rs11415214; rs2593162; rs5786050; rs959189; rs7898921; rs1894270; rs8181334; rs7477139; rs35814383; rs36035697; rs11595017; rs1867981; rs12266725; rs9416010; rs7072424; rs2854990; rs7098225; rs11277133; rs35027678; rs12220614; rs5786049; rs11000023; rs28535035; rs12571681; rs35131935; rs12247334; rs34701833; rs9415054; rs12782637; rs12252719; rs41307569; rs7922360; rs2854989; rs7911004; rs11285654; rs3061818; rs2593161; rs11000026; rs2854985; rs2854991; rs11305283; rs7899796; rs34761785; rs7072021; rs11000021; rs12247599; rs2854988; rs7076038; rs5007340; rs10566090; rs2305203; rs41306532; rs3891337; rs762572; rs5007339; rs10566091; rs2593160; rs3878001; rs35837949; rs7068078; rs35439306; rs12217799; rs35407936; rs34509443; rs35534537; rs2121537; rs35068924; rs11598625; rs34150455; rs28365838; rs7897854; rs34228343; rs10390; rs1054635; rs10762485; rs11000030; rs12252818; rs12416292; rs12774485; rs13377076; rs16929375; rs16929427; rs1867978; rs1992823; rs2290021; rs2290022; rs2394840; rs3802707; rs4746097; rs4747197; rs4747198; rs4747199; rs6480562; rs7085713; rs7092990; rs9415051; rs9415053

# Macromolecular_Interacting_Partner_1_General_References:
2515150; 2498298; 2842863; 1612590; 8323276; 1958198; 2013321; 2717620; 8370464; 2825202; 2868718; 3242555; 2209618; 3442600; 2845979; 3048308; 10562467; 7730378; 11180632; 10406958; 12510003; 10510427; 12518053; 7866401; 2302219; 2320574; 2019586; 2060627

# Macromolecular_Interacting_Partner_1_References:
Not Available

End of HMDB00140

Beginning of HMDB00142
# Accession_No:
HMDB00142

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-09-27 21:31:31

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Formic acid

# Description:
Formic acid is the simplest carboxylic acid.  Formate is an intermediate in normal metabolism.  It takes part in the metabolism of one-carbon compounds and its carbon may appear in methyl groups undergoing transmethylation.  It is eventually oxidized to carbon dioxide. In nature, formic acid is found in the stings and bites of many insects of the order Hymenoptera, including bees and ants. The principal use of formic acid is as a preservative and antibacterial agent in livestock feed. When sprayed on fresh hay or other silage, it arrests certain decay processes and causes the feed to retain its nutritive value longer.

# Synonyms:
Add-F; Ameisensaure; Aminate; Aminic acid; Bilorin; Collo-Bueglatt; Collo-Didax; Formate; Formira; Formisoton; Formylate; Formylic acid; Hydrogen carboxylate; Hydrogen carboxylic acid; Methanoate; Methanoic acid; Methanoic acid monomer; Myrmicyl; Sybest; Wonderbond Hardener M 600L; Sodium Formate 

# Chemical_IUPAC_Name:
Formic acid

# Chemical_Formula:
CH2O2

# Chemical_Structure:
tbl_chemical:::HMDB00142_ZOOM.png:::119283213924157783

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00142_THUMB.png:::119283213786586620

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
carboxylic acid

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
46.00548

# Molecular_Weight_Avg:
46.02538

# Smiles_String_isomeric:
OC=O

# Smiles_String_canonical:
OC=O

# KEGG_Compound_ID:
C00058

# BioCyc_ID:
FORMATE

# PubChem_CID:
284

# PubChem_SID:
11538404; 8023639; 8022653; 8028894; 8022126; 8027964; 8026243; 8022286; 8022666; 8029437; 8025710; 8026232; 8025364; 8028931; 8023489; 8024367; 8027923; 11538380; 10317331; 11532734; 554973; 8023896; 3135041; 10322758; 8022159; 8024117; 8025375; 11538386; 554972; 8028176; 10317662; 10318005; 10322756; 10322100; 8024550; 554971; 11538515; 8028247; 11109914; 8021057; 8024815; 8023490; 8024368; 8026959; 11532769; 8022404; 10317447; 8145237; 8150551; 10318685; 8022088; 11110332; 10323518; 8022685; 10322837; 10531520; 554970; 8021549; 8022082; 8022679; 554969; 10317453; 11538096; 8023980; 8022647; 554974; 551014; 8022194; 10317838; 8028137; 8027456; 8021547; 8028159; 8028169; 8022639; 8022669; 8026748; 8028713; 554976; 538909; 8022565; 8024424; 587336; 149047; 8028722; 854902; 11528325; 5242494; 8028165; 8023674; 854903; 8022642; 8026672; 11538537; 8024820; 8028932; 8021061; 8022751; 554975; 8028714

# OMIM_ID:
138320

# Metagene_ID:
Not Available

# BiGG_ID:
33693

# Wikipedia_ID:
Formic acid

# METLIN_ID:
3202

# Ref_ID:
3384868; 16820930; 9370233; 12126185; 16119839; 15644336; 9113198; 12742704; 8577686; 12727331; 7762816; 11007345; 6615718; 6321058; 15455468; 8553685

# ChEBI_ID:
15740

# CAS_Registry_Number:
64-18-6

# InChI:
InChI=1/CH2O2/c2-1-3/h1H,(H,2,3)

# Synthesis_Reference:
The reduction of carbon dioxide to formic acid with lithium aluminum hydride.     Finholt, Albert E.; Jacobson, Eugene C.    St. Olaf Coll.,  Northfield,  MN,    Journal of the American Chemical Society  (1952),  74  3943-4.

# Melting_Point:
8.4 oC

# Melting_Point_predicted:
18.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1000.0 mg/mL [RIDDICK,JA et al. (1986)]

# H2O_Solubility_Predicted:
477.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Liquid

# LogP:
-0.54 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-0.46 [Predicted by ALOGPS]; -0.3 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Formic acid.pdf:::1132562205536526595

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Formic_acid.mol:::1132723809812553740

# SDF_File_[Text]:
tbl_chemical:::HMDB00142.sdf:::119283213521319187

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00142.pdb:::119283213651942775

# PDB_ID:
1AQ6

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041103_P00_01_HW_1DP_presat.png:::114685632831094320

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041103_P00_01_HW_1DP_presat.zip:::114685632834895113

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041103_P00_01_HW_1DP_Assigned.png:::114685632837518708

# H_NMR_Spectra_Sykes:


# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041103_P00_01_HW_1DP_Presat.zip:::115645621116861683

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
tbl_cnmr:::041103_P00_01_HW_1DC_39.jpg:::114168459531626214

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041103_P00_01_HW_1DC_39.zip:::114168459528661297

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041103_P00_01_HW_1DC_39_Assigned.jpg:::114322959352440992

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041103_P00_01_HW_2DHSQC_14.jpg:::114495777711678877

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041103_P00_01_HW_2DHSQC_14.zip:::114495777713737523

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041103_P00_01_HW_2DHSQC_14_Assigned.jpg:::114495777735817696

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Formic acid.gif:::1132732113375912591

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00142_peaks.txt:::1156309572063641739

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Formic acid_C.gif:::1132737697895850123

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00142_peaks.txt:::1156310761955679901

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000203.png:::116890831296889435

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000203.txt:::116890831323451143

# Cellular_Location:
Cytoplasm (Predicted from LogP); endoplasmic reticulum; Extracellular; mitochondria; nucleus

# Tissue_Location:
Brain; Fibroblasts; Liver; Most Tissues; Nerves; Neurons; Pancreas; Stratum Corneum

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	>0.65	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	6321058
Blood	>10.0	umol/L	Adult:>18_yrs_old	Both	Normal	7762816
Cerebrospinal_Fluid(CSF)	105.0 +/- 62.0	uM	Adult:>18_yrs_old	Both	Normal	HMP Experimental


# Concentration_[Abnormal]:
Urine	44.2 +/- 22.8	umol/mmol_creatinine	Adult:>18_yrs_old	Both	As indicator after occupational exposure to methyl formate	11007345
Urine	79.1 +/- 27.8	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Occupational exposure to methyl formate	11007345
Urine	20.0 +/- 11.0	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Lung Cancer	HMP experimental


# Associated_Disorders:
Alzheimer's Disease; As indicator after occupational exposure to methyl formate; Cachexia; Dementia; Formaldehyde Exposure; Lung Cancer; Metabolic Acidosis; Methanol Poisoning; Occupational exposure to methyl formate

# Pathway_Names:
Glycolysis;Fatty acid metabolism;Bile acid biosynthesis;Valine, leucine and isoleucine degradation;Lysine degradation;Glycerolipid metabolism;Pyruvate metabolism;Propanoate metabolism;Butanoate metabolism;Glyoxylate and dicarboxylate metabolism;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
Glycolysis.jpg;;;valine,leucine,and_isoleucine_degradation.jpg;Lysine_degradation.jpg;;;;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00010;map00071;map00120;map00280;map00310;map00561;map00620;map00640;map00650;map00630;map00280;map00280

# Pathway_Graphs:
Glycolysis_Graph.jpg;;;valine,leucine,and_isoleucine_degradation_Graph.jpg;Lysine_degradation_Graph.jpg;;;;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
Glycolysis.xml;;;valine,leucine,and_isoleucine_degradation.xml;Lysine_degradation.xml;;;;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5532

# Metabolic_Enzyme_1_Name:
Aldehyde dehydrogenase X, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
Aldehyde dehydrogenase family 1 member B1; ALDH class 2

# Metabolic_Enzyme_1_Gene_Name:
ALDH1B1

# Metabolic_Enzyme_1_Protein_Sequence:
>Aldehyde dehydrogenase X, mitochondrial precursor
MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT
TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNLLADLVERDRVYLA
SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCG
QIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITG
YGPTAGAAIAQHMDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADM
EHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGP
QVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP
VQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHT
PFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS

# Metabolic_Enzyme_1_Number_of_Residues:
517

# Metabolic_Enzyme_1_Molecular_Weight:
57239

# Metabolic_Enzyme_1_Theoretical_pI:
6.79

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation

# Metabolic_Enzyme_1_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_1_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_1_Signals:
1-22

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1263008

# Metabolic_Enzyme_1_SwissProt_ID:
AL1B1_HUMAN (P30837)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ALDH1B1

# Metabolic_Enzyme_1_Geneatlas_id:
ALDH1B1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:407

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_1_Gene_Sequence:
>1554 bp
ATGCTGCGCTTCCTGGCACCCCGGCTGCTTAGCCTCCAGGGCAGGACCGCCCTCTACTCC
TCGGCAGCAGCCCTCCCAAGCCCCATTCTGAACCCAGACATCCCCTACAACCAGCTGTTC
ATCAACAATGAATGGCAAGATGCAGTCAGCAAGAAGACCTTCCCGACGGTCAACCCTACC
ACCGGGGAGGTCATCGGGCACGTGGCTGAAGGTGACCGGGCTGATGTGGATCGGGCCGTG
AAAGCAGCCCGGGAAGCCTTCCGCCTGGGGTCCCCATGGCGCCGGATGGATGCCTCTGAG
CGGGGCCGGCTGCTGAACCTCCTGGCAGACCTAGTGGAGCGGGATCGAGTCTACTTGGCC
TCACTCGAGACCTTGGACAATGGGAAGCCTTTCCAAGAGTCTTACGCCTTGGACTTGGAT
GAGGTCATCAAGGTGTATCGGTACTTTGCTGGCTGGGCTGACAAGTGGCATGGCAAGACC
ATCCCCATGCATGGCCAGCATTTCTGCTTCACCCGGCATGAGCCCGTTGGTGTCTGTGGC
CAGATCATCCCGTGGAACTTCCCCTTGGTCATGCAGGGTTGGAAACTTGCCCCGGCACTC
GCCACAGGCAACACTGTGGTTATGAAGGTGGCAGAGCAGACCCCCCTCTCTGCCCTGTAT
TTGGCCTCCCTCATCAAGGAGGCAGGCTTTCCCCCTGGGGTGGTGAACATCATCACGGGG
TATGGCCCAACAGCAGGTGCGGCCATCGCCCAGCACATGGATGTTGACAAAGTTGCCTTC
ACCGGTTCCACCGAGGTGGGCCACCTGATCCAGAAAGCAGCTGGCGATTCCAACCTCAAG
AGAGTCACCCTGGAGCTGGGTGGTAAGAGCCCCAGCATCGTGCTGGCCGATGCTGACATG
GAGCATGCCGTGGAGCAGTGCCACGAAGCCCTGTTCTTCAACATGGGCCAGTGCTGCTGT
GCTGGCTCCCGGACCTTCGTGGAAGAATCCATCTACAATGAGTTTCTCGAGAGAACCGTG
GAGAAAGCAAAGCAGAGGAAAGTGGGGAACCCCTTTGAGCTGGACACCCAGCAGGGGCCT
CAGGTGGACAAGGAGCAGTTTGAACGAGTCCTAGGCTACATCCAGCTTGGCCAGAAGGAG
GGCGCAAAACTCCTCTGTGGCGGAGAGCGTTTCGGGGAGCGTGGTTTCTTCATCAAGCCT
ACTGTCTTTGGTGGCGTGCAGGATGACATGAGAATTGCCAAAGAGGAGATCTTTGGGCCT
GTGCAGCCCCTGTTCAAGTTCAAGAAGATTGAGGAGGTGGTTGAGAGGGCCAACAACACC
AGGTATGGCCTGGCTGCGGCTGTGTTCACCCGGGATCTGGACAAGGCCATGTACTTCACC
CAGGCACTCCAGGCCGGGACCGTGTGGGTAAACACCTACAACATCGTCACCTGCCACACG
CCATTTGGAGGGTTTAAGGAATCTGGAAACGGGAGGGAGCTGGGTGAGGATGGGCTTAAG
GCCTACACAGAGGTAAAGACGGTCACCATCAAGGTTCCTCAGAAGAACTCGTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M63967

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_1_Locus:
9p11.1

# Metabolic_Enzyme_1_SNPs:
rs2228093; rs4878199; rs2073478; rs2073477; rs2228094; rs3043; rs6476701; rs10758494; rs10758495; rs7859877; rs4646772; rs4646774; rs4878802; rs10738997; rs11555705; rs4646773; rs41278335; rs11555706; rs10973781; rs10973782; rs12343271; rs41278337; rs10118683; rs10758496; rs10814687; rs10973774; rs10973779; rs10973783; rs10973785; rs10973786; rs10973787; rs10973789; rs10973792; rs11361; rs11790480; rs11791018; rs11791622; rs12001093; rs12336048; rs12352007; rs12378762; rs13285234; rs13290293; rs1555480; rs1923423; rs1923424; rs2038589; rs34183602; rs35950473; rs4142260; rs4242647; rs4878203; rs4878800; rs4878801; rs4878804; rs4878805; rs4878806; rs4878807; rs4878808; rs4878809; rs4878811; rs6476703; rs7021469; rs7031628; rs7045542; rs7046137; rs7853954; rs7865905; rs7866277; rs7867383; rs911757; rs911758

# Metabolic_Enzyme_1_General_References:
2061311; 8244338

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5528

# Metabolic_Enzyme_2_Name:
Alpha-aminoadipic semialdehyde dehydrogenase

# Metabolic_Enzyme_2_Synonyms:
Alpha-AASA dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenease; P6c dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1

# Metabolic_Enzyme_2_Gene_Name:
ALDH7A1

# Metabolic_Enzyme_2_Protein_Sequence:
>Alphaaminoadipic semialdehyde dehydrogenase
MSTLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADY
EETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQ
EYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIA
MICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVN
LLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQ
RCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEA
KKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWN
NEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRES
GSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ

# Metabolic_Enzyme_2_Number_of_Residues:
511

# Metabolic_Enzyme_2_Molecular_Weight:
55367

# Metabolic_Enzyme_2_Theoretical_pI:
6.86

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H

# Metabolic_Enzyme_2_Pathway:
map00300  Lysine biosynthesis;
 map00310  Lysine degradation

# Metabolic_Enzyme_2_Reaction:
L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.2.1.31

# Metabolic_Enzyme_2_GenBank_ID_Protein:
797410

# Metabolic_Enzyme_2_SwissProt_ID:
AL7A1_HUMAN (P49419)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ALDH7A1

# Metabolic_Enzyme_2_Geneatlas_id:
ALDH7A1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:877

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>1536 bp
ATGTCCACTCTCCTCATCAATCAGCCCCAGTATGCGTGGCTGAAAGAGCTGGGGCTCCGC
GAGGAAAACGAGGGCGTGTATAATGGAAGCTGGGGAGGCCGGGGAGAGGTTATTACGACC
TATTGCCCCGCTAACAACGAGCCAATAGCAAGAGTCCGACAGGCCAGTGTGGCAGACTAT
GAAGAAACTGTAAAGAAAGCAAGAGAAGCATGGAAAATCTGGGCAGATATTCCTGCTCCA
AAACGAGGAGAAATAGTAAGACAGATTGGCGATGCCTTGCGGGAGAAGATCCAAGTACTA
GGAAGCTTGGTGTCTTTGGAGATGGGGAAAATCTTAGTGGAAGGTGTGGGTGAAGTTCAG
GAGTATGTGGATATCTGTGACTATGCTGTTGGTTTATCAAGGATGATTGGAGGACCTATC
TTGCCTTCTGAAAGATCTGGCCATGCACTGATTGAGCAGTGGAATCCCGTAGGCCTGGTT
GGAATCATCACGGCATTCAATTTCCCTGTGGCAGTGTATGGTTGGAACAACGCCATCGCC
ATGATCTGTGGAAATGTCTGCCTCTGGAAAGGAGCTCCAACCACTTCCCTCATTAGTGTG
GCTGTCACAAAGATAATAGCCAAGGTTCTGGAGGACAACAAGCTGCCTGGTGCAATTTGT
TCCTTGACTTGTGGTGGAGCAGATATTGGCACAGCAATGGCCAAAGATGAACGAGTGAAC
CTGCTGTCCTTCACTGGGAGCACTCAGGTGGGAAAACAGGTGGGCCTGATGGTGCAGGAG
AGGTTTGGGAGAAGTCTGTTGGAACTTGGAGGAAACAATGCCATTATTGCCTTTGAAGAT
GCAGACCTCAGCTTAGTTGTTCCATCAGCTCTCTTCGCTGCTGTGGGAACAGCTGGCCAG
AGGTGTACCACTGCGAGGCGACTGTTTATACATGAAAGCATCCATGATGAGGTTGTAAAC
AGACTTAAAAAGGCCTATGCACAGATCCGAGTTGGGAACCCATGGGACCCTAATGTTCTC
TATGGGCCACTCCACACCAAGCAGGCAGTGAGCATGTTTCTTGGAGCAGTGGAAGAAGCA
AAGAAAGAAGGTGGCACAGTGGTCTATGGGGGCAAGGTTATGGATCGCCCTGGAAATTAT
GTAGAACCGACAATTGTGACAGGTCTTGGCCACGATGCGTCCATTGCACACACAGAGACT
TTCGCTCCGATTCTCTATGTCTTTAAATTCAAGAATGAAGAAGAGGTCTTTGCATGGAAT
AATGAAGTAAAACAGGGACTTTCAAGTAGCATCTTTACCAAAGATCTGGGCAGAATCTTT
CGCTGGCTTGGACCTAAAGGATCAGACTGTGGCATTGTAAATGTCAACATTCCAACAAGT
GGGGCTGAGATTGGAGGTGCCTTTGGAGGAGAAAAGCACACTGGTGGTGGCAGGGAGTCT
GGCAGTGATGCCTGGAAACAGTACATGAGAAGGTCTACTTGTACTATCAACTACAGTAAA
GACCTTCCTCTGGCCCAAGGAATCAAGTTTCAGTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
S74728

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_2_Locus:
5q31

# Metabolic_Enzyme_2_SNPs:
rs12514417; rs2306618; rs2775; rs1038381; rs6595719; rs4835912; rs1038378; rs1038380; rs2306617; rs4379190; rs4836276; rs11241901; rs4240406; rs12513847; rs7709115; rs4836272; rs7713264; rs6870785; rs11241902; rs7714044; rs1038379; rs10050642; rs7723008; rs4836277; rs3734175; rs6898430; rs17154671; rs4626334; rs13182402; rs17154679; rs4835914; rs12653605; rs2306619; rs7719675; rs10478743; rs7700981; rs2035472; rs11241903; rs6861395; rs7724875; rs2291295; rs10519915; rs7719712; rs6898559; rs4626335; rs17154676; rs11952752; rs13179664; rs4835913; rs11742214; rs3734174; rs11742381; rs7736031; rs7737529; rs10478744; rs4836275; rs17154666; rs34241005; rs10043987; rs7718426; rs2013986; rs10067785; rs7719091; rs17165056; rs13188450; rs900645; rs7708281; rs7703958; rs7723494; rs10050872; rs7702811; rs13171814; rs6897789; rs13177576; rs7704283; rs4526102; rs11741551; rs10038571; rs4836273; rs3736174; rs3736171; rs1483780; rs900641; rs744722; rs900640; rs7718710; rs1060856; rs744720; rs17165061; rs744721; rs1807; rs6865317; rs6884473; rs7447092; rs3189320; rs1049217; rs1049211; rs11542969; rs1049214; rs11269202; rs6898845; rs35027610; rs35284915; rs34275373; rs35570062; rs34674137; rs28429591; rs7730016; rs4612066; rs36058537; rs2408702; rs11406545; rs1142071; rs13356526; rs35492150; rs34697893; rs10539406; rs34825424; rs7703752; rs12187161; rs34949719; rs36125577; rs36077292; rs7719949; rs35736560; rs34201518; rs33926729; rs34250591; rs13185811; rs34323751; rs34907915; rs28865092; rs35559498; rs35109136; rs10630162; rs4836274; rs34972014; rs13173864; rs7709981; rs6870070; rs2408703; rs35118533; rs10532390; rs34517958; rs34069611; rs10629966; rs7706009; rs34496788; rs34935903; rs35115612; rs13174679; rs10609859; rs34995966; rs34074703; rs36120385; rs34424711; rs34537297; rs7737783; rs35457522; rs35367836; rs36017518; rs17597559; rs7730933; rs33954485; rs35196030; rs35930104; rs34575294; rs10666972; rs10676689; rs35010266; rs34035179; rs28629815; rs7704352; rs35797169; rs10044223; rs35622239; rs35960414; rs34959052; rs35342756; rs13154789; rs4836278; rs35617751; rs34731336; rs12656014; rs34305021; rs34684581; rs5871220; rs11951146; rs35290920; rs13166319; rs2408633; rs11290126; rs34862437; rs35992646; rs35110442; rs10609860; rs11742868; rs6896807; rs17531712; rs34770295; rs3080835; rs11387172; rs7737256; rs34601459; rs9765047; rs1060857; rs3736172; rs11458774; rs1138001; rs7447380; rs5871218; rs1138005; rs34410568; rs3736173; rs35569843; rs744723; rs5871219; rs34450389; rs34135005; rs3830274; rs11750167; rs1384880; rs17154635; rs2035471; rs2128931; rs2306620; rs2306621; rs2306622; rs2408700; rs28365789; rs3734173; rs4240405; rs4597966; rs4835911; rs4836271; rs6882015; rs730870; rs7715516; rs7726892

# Metabolic_Enzyme_2_General_References:
8088832; 9417906

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5628

# Metabolic_Enzyme_3_Name:
Glyoxylate reductase/hydroxypyruvate reductase

# Metabolic_Enzyme_3_Synonyms:
Not Available

# Metabolic_Enzyme_3_Gene_Name:
GRHPR

# Metabolic_Enzyme_3_Protein_Sequence:
>Glyoxylate reductase/hydroxypyruvate reductase
MRPVRLMKVFVTRRIPAEGRVALARAADCEVEQWDSDEPIPAKELERGVAGAHGLLCLLS
DHVDKRILDAAGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLL
TTCRRLPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRF
LYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVF
INISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIGSATHR
TRNTMSLLAANNLLAGLRGEPMPSELKL

# Metabolic_Enzyme_3_Number_of_Residues:
328

# Metabolic_Enzyme_3_Molecular_Weight:
35669

# Metabolic_Enzyme_3_Theoretical_pI:
7.44

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  L-serine metabolism
Process:  L-serine biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities

# Metabolic_Enzyme_3_Pathway:
map00620  Pyruvate metabolism;
 map00630  Glyoxylate and dicarboxylate metabolism

# Metabolic_Enzyme_3_Reaction:
glycolate + NADP+ = glyoxylate + NADPH + H+

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00389:2-Hacid_dh;
PF02826:2-Hacid_dh_C

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.1.1.79

# Metabolic_Enzyme_3_GenBank_ID_Protein:
6002730

# Metabolic_Enzyme_3_SwissProt_ID:
GRHPR_HUMAN (Q9UBQ7)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
GRHPR

# Metabolic_Enzyme_3_Geneatlas_id:
GRHPR

# Metabolic_Enzyme_3_hgnc_id:
HGNC:4570

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>987 bp
ATGAGACCGGTGCGACTCATGAAGGTGTTCGTCACCCGCAGGATACCCGCCGAGGGTAGG
GTCGCGCTCGCCCGGGCGGCAGACTGTGAGGTGGAGCAGTGGGACTCGGATGAGCCCATC
CCTGCCAAGGAGCTAGAGCGAGGTGTGGCGGGGGCCCACGGCCTGCTCTGCCTCCTCTCC
GACCACGTGGACAAGAGGATCCTGGATGCTGCAGGGGCCAATCTCAAAGTCATCAGCACC
ATGTCTGTGGGCATCGACCACTTGGCTTTGGATGAAATCAAGAAGCGTGGGATCCGAGTT
GGCTACACCCCAGATGTCCTGACAGATACCACCGCCGAACTCGCAGTCTCCCTGCTACTT
ACCACCTGCCGCCGGTTGCCGGAGGCCATCGAGGAAGTGAAGAATGGTGGCTGGACCTCG
TGGAAGCCCCTCTGGCTGTGTGGCTATGGACTCACGCAGAGCACTGTCGGCATCATCGGG
CTGGGGCGCATAGGCCAGGCCATTGCTCGGCGTCTGAAACCATTCGGTGTCCAGAGATTT
CTGTACACAGGGCGCCAGCCCAGGCCTGAGGAAGCAGCAGAATTCCAGGCAGAGTTTGTG
TCTACCCCTGAGCTGGCTGCCCAATCTGATTTCATCGTCGTGGCCTGCTCCTTAACACCT
GCAACCGAGGGACTCTGCAACAAGGACTTCTTCCAGAAGATGAAGGAAACAGCTGTGTTC
ATCAACATCAGCAGGGGCGACGTCGTAAACCAGGACGACCTGTACCAGGCCTTGGCCAGT
GGTAAGATTGCAGCTGCTGGACTGGATGTGACGAGCCCAGAACCACTGCCTACAAACCAC
CCTCTCCTGACCCTGAAGAACTGTGTGATTCTGCCCCACATTGGCAGTGCCACCCACAGA
ACCCGCAACACCATGTCCTTGTTGGCAGCTAACAACTTGCTGGCTGGCCTGAGAGGGGAG
CCGATGCCTAGTGAACTCAAGCTGTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
AF134895

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_3_Locus:
9q12

# Metabolic_Enzyme_3_SNPs:
rs12002324; rs309458; rs309461; rs2768659; rs2736664; rs2768662; rs7867764; rs309455; rs309459; rs1887454; rs309453; rs2768658; rs12552734; rs309452; rs309460; rs309457; rs2235096; rs10973333; rs309456; rs309462; rs17885933; rs17411423; rs12683277; rs10973336; rs2768657; rs10973334; rs309454; rs4472607; rs7856656; rs4878690; rs7872991; rs10973329; rs7853540; rs7857159; rs10973327; rs10973328; rs7872720; rs6476631; rs7853526; rs11546642; rs35975284; rs11546644; rs1057507; rs3198078; rs2736669; rs2736662; rs2768660; rs2736670; rs35891798; rs2736673; rs34288288; rs41278295; rs41298174; rs2736665; rs2736660; rs2736667; rs10973335; rs2736671; rs2736661; rs41303225; rs16934118; rs2736663; rs1807410; rs35417895; rs2736666; rs2736674; rs10643023; rs2736668; rs34302950; rs11345501; rs2736672; rs309451; rs13299681; rs10973331; rs10679296; rs34280344; rs10973332; rs35292277; rs34688490; rs34632389; rs10643132; rs5897688; rs927929; rs34510989; rs10814535; rs10973324; rs10973338; rs10973339; rs10973340; rs11793053; rs12348205; rs13300415; rs17411255; rs17502738; rs1802995; rs2840246; rs309450; rs35680410; rs35720597; rs7022431; rs7031029; rs7038960; rs7039333

# Metabolic_Enzyme_3_General_References:
10524214; 10484776; 10679197

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5531

# Metabolic_Enzyme_4_Name:
Fatty aldehyde dehydrogenase

# Metabolic_Enzyme_4_Synonyms:
Aldehyde dehydrogenase, microsomal; Aldehyde dehydrogenase family 3 member A2; Aldehyde dehydrogenase 10

# Metabolic_Enzyme_4_Gene_Name:
ALDH3A2

# Metabolic_Enzyme_4_Protein_Sequence:
>Fatty aldehyde dehydrogenase
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE
VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ
PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH
IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT
CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI
AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA
LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS
HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV
KAEYY

# Metabolic_Enzyme_4_Number_of_Residues:
485

# Metabolic_Enzyme_4_Molecular_Weight:
54849

# Metabolic_Enzyme_4_Theoretical_pI:
7.99

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length

# Metabolic_Enzyme_4_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_4_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
464-480

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_4_GenBank_ID_Protein:
1082036

# Metabolic_Enzyme_4_SwissProt_ID:
AL3A2_HUMAN (P51648)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
ALDH3A2

# Metabolic_Enzyme_4_Geneatlas_id:
ALDH3A2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:403

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein; cytoplasmic side

# Metabolic_Enzyme_4_Gene_Sequence:
>1458 bp
ATGGAGCTCGAAGTCCGGCGGGTCCGACAGGCGTTCCTGTCCGGCCGGTCGCGACCTCTG
CGGTTTCGGCTGCAGCAGCTGGAGGCCCTGCGGAGGATGGTGCAGGAGCGCGAGAAGGAT
ATCCTGACGGCCATCGCCGCCGACCTGTGCAAGAGTGAATTCAATGTGTACAGTCAGGAA
GTCATTACTGTCCTTGGGGAAATTGATTTTATGCTTGAGAATCTTCCTGAATGGGTTACT
GCTAAACCAGTTAAGAAGAACGTGCTCACCATGCTGGATGAGGCCTATATTCAGCCACAG
CCTCTGGGAGTGGTGCTGATAATCGGAGCTTGGAATTACCCCTTCGTTCTCACCATTCAG
CCACTGATAGGAGCCATCGCTGCAGGAAATGCTGTGATTATAAAGCCTTCTGAACTGAGT
GAAAATACAGCCAAGATCTTGGCAAAGCTTCTCCCTCAGTATTTAGACCAGGATCTCTAT
ATTGTTATTAATGGTGGTGTTGAGGAAACCACGGAGCTCCTGAAGCAGCGATTTGACCAC
ATTTTCTATACGGGAAACACTGCGGTTGGCAAAATTGTCATGGAAGCTGCTGCCAAGCAT
CTGACCCCTGTGACTCTTGAACTGGGAGGGAAAAGTCCATGTTATATTGATAAAGATTGT
GACCTGGACATTGTTTGCAGACGCATAACCTGGGGAAAATACATGAATTGTGGCCAAACC
TGCATTGCACCCGACTATATTCTCTGTGAAGCATCCCTCCAAAATCAAATTGTATGGAAG
ATTAAGGAAACAGTGAAGGAATTTTATGGAGAAAATATAAAAGAGTCTCCTGATTATGAA
AGGATCATCAATCTTCGTCATTTTAAGAGGATACTAAGTTTGCTTGAAGGACAAAAGATA
GCTTTTGGTGGGGAGACTGATGAGGCCACACGCTACATAGCCCCAACAGTACTTACCGAT
GTTGATCCTAAAACCAAGGTGATGCAAGAAGAAATTTTTGGACCAATTCTTCCAATAGTG
CCTGTGAAAAATGTAGATGAGGCCATAAATTTCATAAATGAACGTGAAAAGCCTCTGGCT
CTTTATGTATTTTCGCATAACCATAAGCTCATCAAACGGATGATTGATGAGACATCCAGT
GGAGGTGTCACAGGCAATGACGTCATTATGCACTTCACGCTCAACTCTTTCCCATTTGGA
GGAGTGGGTTCCAGTGGGATGGGAGCTTATCACGGAAAACATAGTTTTGATACTTTTTCT
CATCAGCGTCCCTGTTTATTAAAAAGTTTAAAGAGAGAAGGTGCTAACAAACTCAGATAT
CCTCCCAACAGCCAGTCAAAGGTGGATTGGGGGAAATTTTTTCTCTTGAAACGGTTCAAC
AAAGAAAAACTCGGTCTCCTGTTGCTCACTTTCCTGGGTATTGTAGCCGCTGTGCTTGTC
AAGGCAGAATATTACTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
L47162

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_4_Locus:
17p11.2

# Metabolic_Enzyme_4_SNPs:
rs7216; rs7503517; rs7215; rs16420; rs11204408; rs3786038; rs962801; rs2072333; rs1034897; rs2072331; rs2108971; rs1004490; rs1004491; rs4244600; rs962800; rs8069576; rs4925036; rs2072332; rs16960280; rs4646797; rs8069478; rs2386145; rs1800869; rs11204407; rs4646798; rs4646794; rs4925038; rs4646800; rs4925037; rs4646795; rs4646804; rs4646802; rs8073767; rs12937946; rs9910300; rs4646801; rs9901895; rs1034896; rs3760489; rs4621031; rs3888642; rs1057405; rs11548343; rs12947169; rs34160909; rs35364675; rs7209322; rs35495378; rs12947168; rs12708; rs4646805; rs7215552; rs35965955; rs2386146; rs35716578; rs34082599; rs4646799; rs4646796; rs3034928; rs1800870; rs35581449; rs5819686; rs34567842; rs34350257; rs34642385; rs4646793; rs11652177; rs4646907; rs34471504; rs8073053; rs2386147; rs6146012; rs34945824; rs36031953; rs34327718; rs35797108; rs34664206; rs4646803; rs35265843; rs36025724; rs35053333; rs3841513; rs34368630; rs4646806; rs35604266; rs16960266; rs28375263; rs11868363; rs11871420; rs11871642; rs12937179; rs1804608; rs2386144; rs34399035; rs34416664; rs35526408; rs4646807; rs4925026; rs8065688; rs8074204; rs8074500

# Metabolic_Enzyme_4_General_References:
8528251; 9027499; 9070922; 9254849; 9829906

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5526

# Metabolic_Enzyme_5_Name:
4-trimethylaminobutyraldehyde dehydrogenase

# Metabolic_Enzyme_5_Synonyms:
TMABADH; Aldehyde dehydrogenase 9A1; Aldehyde dehydrogenase E3 isozyme; Gamma-aminobutyraldehyde dehydrogenase; R- aminobutyraldehyde dehydrogenase

# Metabolic_Enzyme_5_Gene_Name:
ALDH9A1

# Metabolic_Enzyme_5_Protein_Sequence:
>4trimethylaminobutyraldehyde dehydrogenase
MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA
AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY
AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK
PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI
MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI
LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY
VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA
AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL
KTVCVEMGDVESAF

# Metabolic_Enzyme_5_Number_of_Residues:
494

# Metabolic_Enzyme_5_Molecular_Weight:
53802

# Metabolic_Enzyme_5_Theoretical_pI:
5.61

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_5_Specific_Function:
Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction

# Metabolic_Enzyme_5_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_5_Reaction:
4-trimethylammoniobutanal + NAD+ = 4-trimethylammoniobutanoate + NADH + H+

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.2.1.47;EC 1.2.1.3;EC

# Metabolic_Enzyme_5_GenBank_ID_Protein:
1049219

# Metabolic_Enzyme_5_SwissProt_ID:
AL9A1_HUMAN (P49189)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ALDH9A1

# Metabolic_Enzyme_5_Geneatlas_id:
ALDH9A1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:412

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1482 bp
ATGAGCACTGGCACCTTCGTCGTGTCGCAGCCGCTCAATTACCGCGGCGGGGCCGCTGGA
GCCGGCGGACGCTCCGGTACCGAGAAAGCTTTCGAGCCAGCAACCGGCCGAGTGATAGCT
ACTTTCACATGTTCAGGAGAAAAGGAAGTAAATTTGGCTGTTCAAAATGCAAAGGCTGCT
TTTAAAATATGGAGTCAAAAATCTGGCATGGAGCGTTGCCGAATCCTTTTGGAGGCTGCC
AGGATAATAAGGGAACGGGAGGATGAAATTGCTACTATGGAGTGCATCAACAATGGCAAG
TCCATCTTTGAGGCCCGCTTGGACATTGACATTTCCTGGCAGTGCCTGGAGTATTATGCG
GGCTTGGCTGCATCCATGGCTGGTGAACACATCCAGCTCCCAGGTGGATCGTTTGGTTAT
ACCAGAAGAGAACCACTTGGGGTATGTGTGGGAATAGGAGCATGGAACTACCCCTTTCAG
ATTGCCTCTTGGAAGTCGGCTCCAGCATTAGCCTGTGGTAATGCCATGGTCTTTAAACCT
TCTCCCTTTACACCTGTTTCTGCATTGCTACTGGCTGAAATCTACAGTGAGGCTGGTGTA
CCTCCTGGGCTCTTCAATGTGGTGCAGGGAGGGGCTGCCACAGGCCAGTTTCTGTGTCAG
CATCCCGATGTGGCCAAAGTCTCCTTCACTGGAAGTGTGCCCACTGGCATGAAGATCATG
GAGATGTCAGCTAAAGGAATCAAACCTGTTACCTTGGAACTTGGAGGCAAATCTCCACTC
ATCATCTTCTCAGACTGTGATATGAACAATGCTGTAAAGGGGGCGCTGATGGCCAACTTC
CTCACACAAGGCCAGGTTTGCTGTAATGGCACAAGAGTATTTGTGCAGAAAGAAATTCTT
GATAAATTTACAGAGGAAGTGGTGAAACAGACCCAAAGGATTAAAATTGGAGATCCCCTT
CTGGAAGATACAAGGATGGGTCCACTCATCAACCGACCACACCTGGAGCGAGTCCTTGGG
TTTGTCAAAGTGGCAAAGGAGCAGGGTGCTAAAGTGTTATGTGGTGGAGATATATATGTA
CCTGAAGATCCCAAATTAAAGGATGGATATTACATGAGACCTTGTGTATTAACTAATTGC
AGAGACGACATGACCTGTGTGAAGGAAGAGATCTTTGGGCCTGTTATGTCCATTTTATCA
TTTGACACTGAAGCTGAGGTTCTAGAAAGAGCCAATGATACCACTTTTGGACTAGCAGCT
GGCGTCTTTACCAGGGACATCCAACGGGCTCATAGAGTGGTAGCTGAGCTTCAGGCTGGG
ACGTGCTTCATTAACAACTATAACGTCAGCCCAGTGGAGTTGCCCTTTGGTGGATATAAG
AAGTCAGGATTTGGCAGAGAGAACGGCCGTGTGACAATCGAATATTATTCACAGCTGAAG
ACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U34252

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_5_Locus:
1q23.1

# Metabolic_Enzyme_5_SNPs:
rs1065756; rs11808728; rs1143659; rs11506; rs12670; rs12408101; rs1913844; rs2882006; rs10753688; rs4646891; rs4646889; rs7516126; rs12565874; rs3820362; rs10800129; rs10800128; rs7534437; rs12072634; rs4656457; rs1337442; rs2348728; rs4578194; rs12080699; rs7541817; rs10918239; rs2348727; rs3738192; rs6683969; rs12065621; rs2348734; rs16849230; rs6426930; rs12083232; rs7513998; rs12122497; rs7555787; rs4646886; rs10800127; rs10918252; rs2348729; rs4646883; rs7518869; rs10800133; rs2176151; rs4646882; rs1538115; rs10800131; rs4646897; rs6690818; rs2050619; rs10753689; rs7546084; rs12076579; rs17482717; rs4657463; rs10918235; rs11587760; rs4274037; rs12567331; rs4557947; rs1337443; rs10800130; rs10800132; rs4646895; rs16849238; rs17450889; rs12033254; rs12069198; rs6657651; rs10918245; rs3845537; rs10918237; rs11807857; rs11807866; rs884121; rs4657462; rs10918236; rs7543204; rs2184918; rs12070650; rs17417191; rs9970857; rs6662419; rs7367737; rs10918242; rs10918241; rs7546322; rs4646888; rs16849374; rs12409168; rs12037790; rs10918247; rs7537071; rs12084748; rs10918238; rs7368130; rs2348730; rs10918244; rs4233407; rs12123278; rs4646892; rs4657466; rs4576644; rs6683651; rs6667075; rs12021795; rs6683665; rs12081464; rs7546215; rs7519162; rs10918240; rs6667088; rs6669697; rs12081903; rs4646885; rs7542184; rs16849479; rs4646887; rs12072664; rs10753687; rs4646896; rs10157944; rs6668102; rs3753893; rs4657468; rs3753892; rs7553712; rs7511691; rs7554409; rs7544840; rs6426928; rs6667681; rs4646881; rs1415503; rs11555775; rs9164; rs4646902; rs6667510; rs11555774; rs4307543; rs11436915; rs34948330; rs12139219; rs34495301; rs10918248; rs1890080; rs35894201; rs4646884; rs28759374; rs12137604; rs28589393; rs34662022; rs12354157; rs10918246; rs35087657; rs34105906; rs35913333; rs34664103; rs12083492; rs2271658; rs34872122; rs7512816; rs4646893; rs7527514; rs12566251; rs1970286; rs3831954; rs2348731; rs10918249; rs35178491; rs36027739; rs35864611; rs17416948; rs4646894; rs11583089; rs12742656; rs12754903; rs12742657; rs41267568; rs4646890; rs12084651; rs4646900; rs34304173; rs13376536; rs12727801; rs41326750; rs28439296; rs12134617; rs12036561; rs35531113; rs3845536; rs36011778; rs12090132; rs7525102; rs10918250; rs3738191; rs12239517; rs4646898; rs34072474; rs34945812; rs10918251; rs1890079; rs35439339; rs36150573; rs1577847; rs12728137; rs34846458; rs4646901; rs36110991; rs12083091; rs34894576; rs6426927; rs11458950; rs1856143; rs35757606; rs41267564; rs41267566; rs35742388; rs10494446; rs10494447; rs10800123; rs10800125; rs10800126; rs10800135; rs10800136; rs10918228; rs10918229; rs10918231; rs10918254; rs10918255; rs10918256; rs11579160; rs11800476; rs11810856; rs12027066; rs12028588; rs12043815; rs12044709; rs12060366; rs12143472; rs12748251; rs1547725; rs16848876; rs16848958; rs16849041; rs16849616; rs1878074; rs1878075; rs2090281; rs2297762; rs2297763; rs2297764; rs2297765; rs3753894; rs3795540; rs4147602; rs4147604; rs4147605; rs4147610; rs4147611; rs4341347; rs7527279; rs7549511; rs7551594; rs8133; rs9333483; rs9333487; rs9919190

# Metabolic_Enzyme_5_General_References:
8786138; 10702312; 8645224; 8269919; 2925663

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5527

# Metabolic_Enzyme_6_Name:
Aldehyde dehydrogenase, dimeric NADP-preferring

# Metabolic_Enzyme_6_Synonyms:
ALDH class 3; ALDHIII

# Metabolic_Enzyme_6_Gene_Name:
ALDH3A1

# Metabolic_Enzyme_6_Protein_Sequence:
>Aldehyde dehydrogenase, dimeric NADPpreferring
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH

# Metabolic_Enzyme_6_Number_of_Residues:
453

# Metabolic_Enzyme_6_Molecular_Weight:
50380

# Metabolic_Enzyme_6_Theoretical_pI:
6.52

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_6_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes

# Metabolic_Enzyme_6_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_6_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_6_GenBank_ID_Protein:
178402

# Metabolic_Enzyme_6_SwissProt_ID:
AL3A1_HUMAN (P30838)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ALDH3A1

# Metabolic_Enzyme_6_Geneatlas_id:
ALDH3A1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:405

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_6_Gene_Sequence:
>1362 bp
ATGAGCAAGATCAGCGAGGCCGTGAAGCGCGCCCGCGCCGCCTTCAGCTCGGGCAGGACC
CGTCCGCTGCAGTTCCGATTCCAGCAGCTGGAGGCGCTGCAGCGCCTGATCCAGGAGCAG
GAGCAGGAGCTGGTGGGCGCGCTGGCCGCAGACCTGCACAAGAATGAATGGAACGCCTAC
TATGAGGAGGTGGTGTACGTCCTAGAGGAGATCGAGTACATGATCCAGAAGCTCCCTGAG
TGGGCCGCGGATGAGCCCGTGGAGAAGACGCCCCAGACTCAGCAGGACGAGCTCTACATC
CACTCGGAGCCACTGGGCGTGGTCCTCGTCATTGGCACCTGGAACTACCCCTTCAACCTC
ACCATCCAGCCCATGGTGGGCGCCATCGCTGCAGGGAACGCAGTGGTCCTCAAGCCCTCG
GAGCTGAGTGAGAACATGGCGAGCCTGCTGGCTACCATCATCCCCCAGTACCTGGACAAG
GATCTGTACCCAGTAATCAATGGGGGTGTCCCTGAGACCACGGAGCTGCTCAAGGAGAGG
TTCGACCATATCCTGTACACGGGCAGCACGGGGGTGGGGAAGATCATCATGACGGCTGCT
GCCAAGCACCTGACCCCTGTCACGCTGGAGCTGGGAGGGAAGAGTCCCTGCTACGTGGAC
AAGAACTGTGACCTGGACGTGGCCTGCCGACGCATCGCCTGGGGGAAATTCATGAACAGT
GGCCAGACCTGCGTGGCCCCAGACTACATCCTCTGTGACCCCTCGATCCAGAACCAAATT
GTGGAGAAGCTCAAGAAGTCACTGAAAGAGTTCTACGGGGAAGATGCTAAGAAATCCCGG
GACTATGGAAGAATCATTAGTGCCCGGCACTTCCAGAGGGTGATGGGCCTGATTGAGGGC
CAGAAGGTGGCTTATGGGGGCACCGGGGATGCCGCCACTCGCTACATAGCCCCCACCATC
CTCACGGACGTGGACCCCCAGTCCCCGGTGATGCAAGAGGAGATCTTCGGGCCTGTGCTG
CCCATCGTGTGCGTGCGCAGCCTGGAGGAGGCCATCCAGTTCATCAACCAGCGTGAGAAG
CCCCTGGCCCTCTACATGTTCTCCAGCAACGACAAGGTGATTAAGAAGATGATTGCAGAG
ACATCCAGTGGTGGGGTGGCGGCCAACGATGTCATCGTCCACATCACCTTGCACTCTCTG
CCCTTCGGGGGCGTGGGGAACAGCGGCATGGGATCCTACCATGGCAAGAAGAGCTTCGAG
ACTTTCTCTCACCGCCGCTCTTGCCTGGTGAGGCCTCTGATGAATGATGAAGGCCTGAAG
GTCAGATACCCCCCGAGCCCGGCCAAGATGACCCAGCACTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M74542

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_6_Locus:
17p11.2

# Metabolic_Enzyme_6_SNPs:
rs887241; rs2228100; rs3744692; rs2072330; rs4646787; rs1042183; rs917520; rs4646789; rs4646788; rs3786036; rs887240; rs2072329; rs4646790; rs3744693; rs9895030; rs3826507; rs3744695; rs3744694; rs2072328; rs1006556; rs4319825; rs1042172; rs11554977; rs11554978; rs11554975; rs11554974; rs34474118; rs3786037; rs35473971; rs4646792; rs35116940; rs4646791; rs35853488; rs887239; rs28531080; rs7216299; rs35009373; rs3786035; rs11385990; rs35308039; rs35128135; rs35885485; rs28552545; rs34438543; rs1006553; rs11650088; rs11651480; rs11870332; rs12948881; rs12949049; rs12951039; rs16960382; rs16960386; rs17793620; rs1989379; rs2016823; rs2052052; rs2072327; rs2108967; rs3760485; rs3760486; rs3760487; rs4646783; rs4646784; rs4646785; rs4646786; rs4924793; rs4925046; rs7214841; rs7221211; rs7225305; rs8075157; rs9898715; rs9900430

# Metabolic_Enzyme_6_General_References:
1737758; 8493892; 2037078; 9250352

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5529

# Metabolic_Enzyme_7_Name:
Aldehyde dehydrogenase 1A3

# Metabolic_Enzyme_7_Synonyms:
Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3

# Metabolic_Enzyme_7_Gene_Name:
ALDH1A3

# Metabolic_Enzyme_7_Protein_Sequence:
>Aldehyde dehydrogenase 1A3
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI
CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM
DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW
NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV
GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE
CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK
QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL
KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF
KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP

# Metabolic_Enzyme_7_Number_of_Residues:
512

# Metabolic_Enzyme_7_Molecular_Weight:
56109

# Metabolic_Enzyme_7_Theoretical_pI:
7.29

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_7_Specific_Function:
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system

# Metabolic_Enzyme_7_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_7_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_7_GenBank_ID_Protein:
544482

# Metabolic_Enzyme_7_SwissProt_ID:
AL1A3_HUMAN (P47895)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
ALDH1A3

# Metabolic_Enzyme_7_Geneatlas_id:
ALDH1A3

# Metabolic_Enzyme_7_hgnc_id:
HGNC:409

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_7_Gene_Sequence:
>1539 bp
ATGGCCACCGCTAACGGGGCCGTGGAAAACGGGCAGCCGGACGGGAAGCCGCCGGCCCTG
CCGCGCCCCATCCGCAACCTGGAGGTCAAGTTCACCAAGATATTTATCAACAATGAATGG
CACGAATCCAAGAGTGGGAAAAAGTTTGCTACATGTAACCCTTCAACTCGGGAGCAAATA
TGTGAAGTGGAAGAAGGAGATAAGCCCGACGTGGACAAGGCTGTGGAGGCTGCACAGGTT
GCCTTCCAGAGGGGCTCGCCATGGCGCCGGCTGGATGCCCTGAGTCGTGGGCGGCTGCTG
CACCAGCTGGCTGACCTGGTGGAGAGGGACCGCGCCACCTTGGCCGCCCTGGAGACGATG
GATACAGGGAAGCCATTTCTTCATGCTTTTTTCATCGACCTGGAGGGCTGTATTAGAACC
CTCAGATACTTTGCAGGGTGGGCAGACAAAATCCAGGGCAAGACCATCCCCACAGATGAC
AACGTCGTATGCTTCACCAGGCATGAGCCCATTGGTGTCTGTGGGGCCATCACTCCATGG
AACTTCCCCCTGCTGATGCTGGTGTGGAAGCTGGCACCCGCCCTCTGCTGTGGGAACACC
ATGGTCCTGAAGCCTGCGGAGCAGACACCTCTCACCGCCCTTTATCTCGGCTCTCTGATC
AAAGAGGCCGGGTTCCCTCCAGGAGTGGTGAACATTGTGCCAGGATTCGGGCCCACAGTG
GGAGCAGCAATTTCTTCTCACCCTCAGATCAACAAGATCGCCTTCACCGGCTCCACAGAG
GTTGGAAAACTGGTTAAAGAAGCTGCGTCCCGGAGCAATCTGAAGCGGGTGACGCTGGAG
CTGGGGGGGAAGAACCCCTGCATCGTGTGTGCGGACGCTGACTTGGACTTGGCAGTGGAG
TGTGCCCATCAGGGAGTGTTCTTCAACCAAGGCCAGTGTTGCACGGCAGCCTCCAGGGTG
TTCGTGGAGGAGCAGGTCTACTCTGAGTTTGTCAGGCGGAGCGTGGAGTATGCCAAGAAA
CGGCCCGTGGGAGACCCCTTCGATGTCAAAACAGAACAGGGGCCTCAGATTGATCAAAAG
CAGTTCGACAAAATCTTAGAGCTGATCGAGAGTGGGAAGAAGGAAGGGGCCAAGCTGGAA
TGCGGGGGCTCAGCCATGGAAGACAAGGGGCTCTTCATCAAACCCACTGTCTTCTCAGAA
GTCACAGACAACATGCGGATTGCCAAAGAGGAGATTTTCGGGCCAGTGCAACCAATACTG
AAGTTCAAAAGTATCGAAGAAGTGATAAAAAGAGCGAATAGCACCGACTATGGACTCACA
GCAGCCGTGTTCACAAAAAATCTCGACAAAGCCCTGAAGTTGGCTTCTGCCTTAGAGTCT
GGAACGGTCTGGATCAACTGCTACAACGCCCTCTATGCACAGGCTCCATTTGGTGGCTTT
AAAATGTCAGGAAATGGCAGAGAACTAGGTGAATACGCTTTGGCCGAATACACAGAAGTG
AAAACTGTCACCATCAAACTTGGCGACAAGAACCCCTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
U07919

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_7_Locus:
15q26.3

# Metabolic_Enzyme_7_SNPs:
rs3803430; rs2229183; rs1130738; rs14226; rs3803424; rs7045; rs3803426; rs7182089; rs4646690; rs7161860; rs4246328; rs4646688; rs4646668; rs4646670; rs3803428; rs4646671; rs6598396; rs4646675; rs9944290; rs7181897; rs4646684; rs4246323; rs4246327; rs4246329; rs4646674; rs8039374; rs4646678; rs4646653; rs4646655; rs7182884; rs3809521; rs11854028; rs3825926; rs3803433; rs6598397; rs4646662; rs4646685; rs4646651; rs4646672; rs3922685; rs4646654; rs3902902; rs4646683; rs7176046; rs3803432; rs4246324; rs4646661; rs8030776; rs12903828; rs4646687; rs4646680; rs3825925; rs7178221; rs3803427; rs7170197; rs4246325; rs8023972; rs4646681; rs7167278; rs4246326; rs1886; rs4646649; rs12908902; rs7171776; rs3803429; rs12914598; rs4646669; rs4646650; rs3803434; rs4646660; rs4646682; rs3809524; rs3809523; rs3809526; rs7179268; rs1130737; rs3803431; rs1130768; rs34302490; rs28760343; rs35300460; rs1802602; rs1802604; rs4288979; rs3803425; rs1802603; rs4646663; rs28691047; rs28731371; rs34655770; rs35165034; rs28509297; rs10400871; rs35129664; rs12905372; rs28405557; rs34486175; rs28546254; rs35055541; rs4646686; rs28441320; rs28410143; rs4646676; rs4646648; rs8029933; rs12910188; rs34182689; rs28504296; rs28449981; rs28507582; rs3825927; rs35310246; rs12910025; rs28384196; rs4343265; rs12910662; rs8028283; rs28475530; rs4392045; rs28369514; rs28377287; rs8035722; rs28480133; rs28707102; rs28583888; rs4646666; rs7173413; rs28472416; rs28673034; rs28668881; rs28711429; rs34837038; rs4646659; rs28452487; rs28712665; rs12910029; rs12902704; rs4646673; rs28689536; rs28431101; rs34431941; rs7178645; rs28454526; rs7170202; rs1889; rs4646647; rs4375646; rs11348272; rs4646656; rs28408085; rs28699556; rs28615197; rs28539744; rs28557216; rs28631565; rs34302839; rs3923499; rs4646664; rs35740226; rs28385499; rs3922686; rs28474807; rs28490217; rs12909825; rs10593974; rs28679806; rs28610999; rs7178553; rs35519561; rs35831758; rs35526807; rs4646658; rs28538652; rs28685242; rs10400842; rs4646667; rs35948146; rs4646677; rs7165217; rs10400872; rs28750207; rs3825924; rs7171453; rs34906846; rs4646665; rs9920154; rs36081993; rs11435500; rs28464660; rs4646679; rs12595234; rs4646689; rs3809522; rs35950557; rs3809527; rs7172149; rs7178931; rs8034153; rs7183889; rs3809525; rs4646646; rs11630601; rs11630691; rs11632820; rs11637204; rs11854709; rs12148466; rs12148493; rs12440023; rs12593839; rs12901792; rs12907776; rs12908105; rs12909230; rs12909791; rs28507591; rs3803435; rs4346184; rs4646694; rs7163108; rs7164136; rs7181644; rs8034686; rs8035036

# Metabolic_Enzyme_7_General_References:
7698756

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5530

# Metabolic_Enzyme_8_Name:
Aldehyde dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_8_Synonyms:
ALDH class 2; ALDHI; ALDH-E2

# Metabolic_Enzyme_8_Gene_Name:
ALDH2

# Metabolic_Enzyme_8_Protein_Sequence:
>Aldehyde dehydrogenase, mitochondrial precursor
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS

# Metabolic_Enzyme_8_Number_of_Residues:
517

# Metabolic_Enzyme_8_Molecular_Weight:
56382

# Metabolic_Enzyme_8_Theoretical_pI:
7.05

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_8_Specific_Function:
An aldehyde + NAD(+) + H(2)O = an acid + NADH

# Metabolic_Enzyme_8_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_8_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_8_Signals:
1-24

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_8_GenBank_ID_Protein:
28606

# Metabolic_Enzyme_8_SwissProt_ID:
ALDH2_HUMAN (P05091)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
ALDH2

# Metabolic_Enzyme_8_Geneatlas_id:
ALDH2

# Metabolic_Enzyme_8_hgnc_id:
HGNC:404

# Metabolic_Enzyme_8_PDB_ID:
1OF7

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_8_Gene_Sequence:
>1551 bp
ATGTTGCGCGCTGCCGCCGCTCGGGCCCCGCCTGGCCGCCGCCTCTTGTCAGCCGCCGCC
ACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTTCATA
AACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACT
GGAGAGGTCATCTGTCAGGTAGCTGAAGGGGACAAGGAAGATGTGGACAAGGCACGTGAA
GGCCGCCCGGGCGCCTTCCAGCTGGGCTCACCTTGGCGCCGCATGGACGCATCACACAGC
GGCCGGCTGCTGAACCGCCTGGCCGATCTGATCGAGCGGGACCGGACCTACCTGGCGGCC
TTGGAGACCCTGGACAATGGCAAGCCCTATGTCATCTCCTACCTGGTGGATTTGGACATG
GTCCTCAAATGTCTCCGGTATTATGCCGGCTGGGCTGATAAGTACCACGGGAAAACCATC
CCCATTGACGGAGACTTCTTCAGCTACACACGCCATGAACCTGTGGGGGTGTGCGGGCAG
ATCATTCCGTGGAATTTCCCGCTCCTGATGCAAGCATGGAAGCTGGGCCCAGCCTTGGCA
ACTGGAAACGTGGTTGTGATGAAGGTAGCTGAGCAGACACCCCTCACCGCCCTCTATGTG
GCCAACCTGATCAAGGAGGCTGGCTTTCCCCCTGGTGTGGTCAACATTGTGCCTGGATTT
GGCCCCACGGCTGGGGCCGCCATTGCCTCCCATGAGGATGTGGACAAAGTGGCATTCACA
GGCTCCACTGAGATTGGCCGCGTAATCCAGGTTGCTGCTGGGAGCAGCAACCTCAAGAGA
GTGACCTTGGAGCTGGGGGGGAAGAGCCCCAACATCATCATGTCAGATGCCGATATGGAT
TGGGCCGTGGAACAGGCCCACTTCGCCCTGTTCTTCAACCAGGGCCAGTGCTGCTGTGCC
GGCTCCCGGACCTTCGTGCAGGAGGACATCTATGATGAGTTTGTGGTGCGGAGCGTTGCC
CGGGCCAAGTCTCGGGTGGTCGGGAACCCCTTTGATAGCAAGACCGAGCAGGGGCCGCAG
GTGGATGAAACTCAGTTTAAGAAGATCCTCGGCTACATCAACACGGGGAAGCAAGAGGGG
GCGAAGCTGCTGTGTGGTGGGGGCATTGCTGCTGACCGTGGTTACTTCATCCAGCCCACT
GTGTTTGGAGATGTGCAGGATGGCATGACCATCGCCAAGGAGGAGATCTTCGGGCCAGTG
ATGCAGATCCTGAAGTTCAAGACCATAGAGGAGGTTGTTGGGAGAGCCAACAATTCCACG
TACGGGCTGGCCGCAGCTGTCTTCACAAAGGATTTGGACAAGGCCAATTACCTGTCCCAG
GCCCTCCAGGCGGGCACTGTGTGGGTCAACTGCTATGATGTGTTTGGAGCCCAGTCACCC
TTTGGTGGCTACAAGATGTCGGGGAGTGGCCGGGAGTTGGGCGAGTACGGGCTGCAGGCA
TACACTGAAGTGAAAACTGTCACAGTCAAAGTGCCTCAGAAGAACTCATAA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X05409

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_8_Locus:
12q24.2

# Metabolic_Enzyme_8_SNPs:
rs671; rs1062136; rs6490301; rs886205; rs2238151; rs968529; rs7296651; rs441; rs4767939; rs10744777; rs4646778; rs4767944; rs10849970; rs2158029; rs4646776; rs7312055; rs7311852; rs2238152; rs4646777; rs2283354; rs10774637; rs4648328; rs10774638; rs11609628; rs11066028; rs4646779; rs16941669; rs440; rs7397491; rs11834780; rs16941667; rs4646775; rs11066029; rs35154896; rs11066024; rs2106696; rs11613231; rs2158028; rs4767035; rs13306166; rs34083959; rs7136890; rs13306164; rs1064933; rs34477327; rs34884061; rs28633753; rs11442381; rs11615695; rs11066023; rs35511855; rs35781311; rs13306163; rs7397456; rs35050853; rs35642129; rs12312867; rs12829533; rs11407827; rs34480430; rs12314397; rs35264878; rs12813835; rs12322000; rs34896918; rs35650885; rs7970477; rs11066025; rs13306167; rs11066027; rs12301347; rs11614684; rs35700215; rs35746295; rs34587287; rs13306165; rs35786282; rs11066022; rs7397469; rs11066030; rs10450717; rs35693865; rs11503169; rs35546929; rs33973376; rs34497874; rs12830829; rs35061167; rs11609093; rs36073646; rs34108639; rs12824249; rs11610258; rs35147079; rs11613713; rs11066026; rs7486832; rs12099590; rs3832868; rs34300515; rs35212101; rs7398472; rs35239056; rs35752199; rs5800933; rs11613351; rs5023470; rs34587619; rs4646781; rs4646780; rs11304348; rs12305979; rs4646782; rs10849969; rs10849971; rs11066032; rs14630; rs2339839; rs2339840; rs7133964; rs737280; rs739580; rs7974339; rs7978737; rs9971942

# Metabolic_Enzyme_8_General_References:
3582651; 3562250; 2838413; 4065146; 2987944; 4015823; 3610592; 3653404; 6582480; 8561277; 10631996

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
6878

# Metabolic_Enzyme_9_Name:
Catalase

# Metabolic_Enzyme_9_Synonyms:
Not Available

# Metabolic_Enzyme_9_Gene_Name:
CAT

# Metabolic_Enzyme_9_Protein_Sequence:
>Catalase
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT
KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD
THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE
HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK
NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL

# Metabolic_Enzyme_9_Number_of_Residues:
527

# Metabolic_Enzyme_9_Molecular_Weight:
59757

# Metabolic_Enzyme_9_Theoretical_pI:
7.41

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  catalase activity
 ||
>>>
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide

# Metabolic_Enzyme_9_Pathway:
map00380  Tryptophan metabolism;
 map00680  Methane metabolism

# Metabolic_Enzyme_9_Reaction:
2 H2O2 = O2 + 2 H2O

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00199:Catalase

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 1.11.1.6

# Metabolic_Enzyme_9_GenBank_ID_Protein:
1228085

# Metabolic_Enzyme_9_SwissProt_ID:
CATA_HUMAN (P04040)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
CAT

# Metabolic_Enzyme_9_Geneatlas_id:
CAT

# Metabolic_Enzyme_9_hgnc_id:
HGNC:1516

# Metabolic_Enzyme_9_PDB_ID:
1F4J

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_9_Gene_Sequence:
>66 bp
ATGGCTGACAGCCGGGATCCCGCCAGCGACCAGATGCAGCACTGGAAGGAGCAGCGGGCC
GCGCAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
X04085

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_9_Locus:
11p13

# Metabolic_Enzyme_9_SNPs:
rs17880442; rs11032709; rs769217; rs35677492; rs1049982; rs2234940; rs1050032; rs566979; rs769218; rs511895; rs524167; rs494024; rs1408035; rs560807; rs10488736; rs2284367; rs482322; rs7947841; rs480496; rs11032699; rs2300182; rs2284365; rs7103083; rs499406; rs3758730; rs4755372; rs508370; rs7933285; rs1000343; rs554576; rs2073059; rs11032701; rs17886008; rs4755373; rs484214; rs6484722; rs543701; rs17884666; rs2420389; rs551929; rs480575; rs10836244; rs2179625; rs7113917; rs2268063; rs533425; rs12272630; rs17881488; rs486256; rs17884576; rs2073058; rs11604331; rs17884491; rs7120960; rs1408034; rs524154; rs7109778; rs7101395; rs17881288; rs12269988; rs7126610; rs10836235; rs16925608; rs16925614; rs11824384; rs2284368; rs17883121; rs2420388; rs4756146; rs16925606; rs17884086; rs2284364; rs7930427; rs12803540; rs1408036; rs17268652; rs2284366; rs17881567; rs2300181; rs7928213; rs11032702; rs16925581; rs525938; rs11032700; rs17881921; rs17884095; rs17885743; rs17881476; rs17883793; rs11826620; rs12270780; rs35915891; rs2268064; rs17883592; rs17884725; rs17881482; rs17880673; rs2284369; rs17883544; rs11032703; rs12273124; rs17884248; rs35755143; rs7126640; rs2076556; rs4755374; rs1055981; rs17884335; rs17884518; rs17880274; rs17883699; rs4756148; rs17886200; rs475043; rs564250; rs769214; rs9282626; rs7943316; rs9282627; rs7104301; rs17883920; rs1001179; rs17881029; rs17886350; rs2266625; rs34455645; rs3180560; rs11546300; rs1050028; rs2266629; rs2266619; rs14527; rs2266628; rs35012776; rs34964953; rs34727149; rs3831770; rs17886810; rs35927227; rs7121850; rs17885881; rs17882812; rs17885837; rs17880607; rs17882039; rs17881916; rs17880549; rs34138762; rs28586982; rs34503767; rs36074933; rs515130; rs35099202; rs35849009; rs17881846; rs17887048; rs17881224; rs17884421; rs34840731; rs17881231; rs35340649; rs35292563; rs17884242; rs12286702; rs35034960; rs28733253; rs17887248; rs35791482; rs35703808; rs35648206; rs34808995; rs35386961; rs34420404; rs856714; rs17883483; rs17884804; rs17883367; rs17883534; rs17880160; rs17886672; rs34281397; rs34790990; rs2982523; rs35122257; rs2284370; rs12798927; rs35781217; rs11032707; rs17886592; rs4483566; rs34890123; rs4272763; rs12789374; rs17881734; rs35330036; rs17883434; rs35081167; rs17886155; rs17886248; rs34840787; rs34890990; rs17881192; rs17881586; rs34267165; rs12786539; rs35834969; rs3818354; rs17884443; rs36224415; rs36224416; rs36224102; rs10312; rs10836230; rs10836233; rs10836234; rs11032717; rs1107573; rs11606946; rs12284341; rs12807961; rs12808450; rs1323690; rs1535718; rs1535719; rs1535720; rs1535721; rs16925525; rs2073057; rs208678; rs208679; rs208681; rs208682; rs208683; rs2231828; rs2266624; rs2266630; rs2296144; rs409598; rs554518; rs7109862; rs7114869; rs7118388; rs7928156; rs7941147; rs7944397; rs7949972

# Metabolic_Enzyme_9_General_References:
3755525; 3755526; 11728823; 8282800; 12665801; 6548744; 10666617; 10656833; 11134921

# Metabolic_Enzyme_9_References:
14646074; 15940012

# Metabolic_Enzyme_10_ID:
8750

# Metabolic_Enzyme_10_Name:
Methylenetetrahydrofolate dehydrogenase

# Metabolic_Enzyme_10_Synonyms:
NADP+ dependent1-like

# Metabolic_Enzyme_10_Gene_Name:
MTHFD1L

# Metabolic_Enzyme_10_Protein_Sequence:
>Methylenetetrahydrofolate dehydrogenase
NIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCY
HWSVGGKGSVDLARAVREAASKRSRFQFLYDVQPFS

# Metabolic_Enzyme_10_Number_of_Residues:
96

# Metabolic_Enzyme_10_Molecular_Weight:
10560

# Metabolic_Enzyme_10_Theoretical_pI:
8.33

# Metabolic_Enzyme_10_GO_Classification:
>>>
 Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  formate-tetrahydrofolate ligase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  aromatic compound metabolism
Process:  folic acid and derivative metabolism
Process:  folic acid and derivative biosynthesis
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Nucleotide transport and metabolism

# Metabolic_Enzyme_10_Specific_Function:
Not Available

# Metabolic_Enzyme_10_Pathway:
Not Available

# Metabolic_Enzyme_10_Reaction:
Not Available

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF01268:FTHFS

# Metabolic_Enzyme_10_Signals:
Not Available

# Metabolic_Enzyme_10_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 1.5.1.5;EC 6.3.4.3;EC 3.5.4.9

# Metabolic_Enzyme_10_GenBank_ID_Protein:
66347263

# Metabolic_Enzyme_10_SwissProt_ID:
Q4VXV2_HUMAN (Q4VXV2)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
MTHFD1L

# Metabolic_Enzyme_10_Geneatlas_id:
MTHFD1L

# Metabolic_Enzyme_10_hgnc_id:
HGNC:21055

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Not Available

# Metabolic_Enzyme_10_Gene_Sequence:
>291 bp
AACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAG
CTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAG
ATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTAT
CACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCG
AGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGCCATTCTCTTGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
AL049694

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_10_Locus:
6q25.1

# Metabolic_Enzyme_10_SNPs:
Not Available

# Metabolic_Enzyme_10_General_References:
Not Available

# Metabolic_Enzyme_10_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8324

# Macromolecular_Interacting_Partner_1_Name:
Sodium/hydrogen exchanger 3

# Macromolecular_Interacting_Partner_1_Synonyms:
Na(+/H(+exchanger 3; NHE-3; Solute carrier family 9 member 3

# Macromolecular_Interacting_Partner_1_Gene_Name:
SLC9A3

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Sodium/hydrogen exchanger 3
MWGLGARGPDRGLLLALALGGLARAGGVEVEPGGAHGESGGFQVVTFEWAHVQDPYVIAL
WILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLL
PPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLD
FLLFGSLMAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGD
NVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLT
SEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVN
PFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAF
ALVVLLDGDKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLH
GRAFDHILSAIEDISGQIGHNYLRDKWSHFDRKFLSRVLMRRSAQKSRDRILNVFHELNL
KDAISYVAEGERRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQS
LEQRRRSIRDAEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKR
LESFKSTKLGLNQNKKAAKLYKRERAQKRRNSSIPNGKLPMESPAQNFTIKEKDLELSDT
EEPPNYDEEMSGGIEFLASVTKDTASDSPAGIDNPVFSPDEALDRSLLARLPPWLSPGET
VVPSQRARTQIPYSPGTFRRLMPFRLSSKSVDSFLQADGPEERPPAALPESTHM

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
834

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
92909

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  monovalent inorganic cation transporter activity
Function:  hydrogen ion transporter activity
Function:  monovalent cation:proton antiporter activity
Function:  sodium:hydrogen antiporter activity
Function:  transporter activity
Function:  ion transporter activity
Function:  cation transporter activity
Function:  solute:cation antiporter activity
Function:  solute:hydrogen antiporter activity
 ||
>>>
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  cation transport
Process:  monovalent inorganic cation transport
Process:  sodium ion transport
Process:  physiological process
Process:  homeostasis
Process:  ion homeostasis
Process:  regulation of pH
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00999:Na_H_Exchanger

# Macromolecular_Interacting_Partner_1_Signals:
1-25

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
80-99
113-133
140-160
181-202
211-232
253-274
291-309
341-362
370-390
436-456

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
971209

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
SL9A3_HUMAN (P48764)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
SLC9A3

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
SLC9A3

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:11073

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>2505 bp
ATGTGGGGACTCGGGGCCCGGGGCCCCGACCGGGGGCTGCTGCTGGCGCTGGCGCTGGGC
GGGCTGGCGCGGGCCGGGGGCGTCGAGGTGGAGCCCGGCGGCGCGCACGGCGAGAGCGGG
GGCTTCCAGGTGGTCACCTTCGAGTGGGCCCACGTGCAGGATCCCTACGTCATCGCGCTC
TGGATCCTCGTGGCCAGCTTGGCCAAGATCGGGTTCCACCTGTCCCACAAGGTCACCAGC
GTGGTTCCCGAGAGCGCCCTGCTCATCGTGCTGGGCCTGGTGCTGGGCGGCATCGTCTGG
GCGGCCGACCACATCGCGTCCTTCACACTGACGCCCACCGTCTTCTTCTTCTACCTGCTG
CCCCCCATCGTGCTGGACGCCGGCTACTTCATGCCCAACCGCCTCTTCTTCGGCAACCTG
GGGACCATCCTGTTGTACGCCGTCGTGGGTACCGTGTGGAACGCGGCCACCACCGGGCTG
TCCCTCTACGGCGTCTTCCTCAGTGGGCTCATGGGCGACCTGCAGATTGGGCTGCTGGAC
TTCCTCCTGTTTGGCAGCCTCATGGCGGCTGTGGACCCGGTGGCCGTCCTGGCCGTGTTT
GAGGAGGTCCATGTCAACGAGGTCCTGTTCATCATCGTCTTCGGGGAGTCGCTGCTGAAC
GACGCAGTCACCGTGGTTCTGTACAATGTGTTTGAATCTTTCGTGGCGCTGGGAGGTGAC
AACGTGACTGGCGTGGACTGCGTGAAGGGCATAGTGTCCTTCTTCGTGGTGAGCCTGGGG
GGCACGCTGGTGGGGGTGGTCTTCGCCTTCCTGCTGTCGCTGGTGACGCGCTTCACCAAG
CATGTGCGTATCATCGAGCCCGGCTTCGTGTTCATCATCTCCTACCTGTCCTACCTGACG
TCCGAGATGCTGTCGCTGTCGGCCATCCTCGCCATCACCTTCTGTGGCATCTGCTGTCAG
AAGTATGTGAAGGCCAACATCTCGGAGCAGTCGGCCACCACCGTGCGCTACACCATGAAG
ATGCTGGCCAGCAGCGCCGAGACCATCATCTTCATGTTCCTGGGTATCTCGGCCGTGAAC
CCGTTCATCTGGACCTGGAACACGGCCTTCGTGCTCCTGACGCTGGTCTTCATCTCCGTG
TACCGGGCCATCGGTGTGGTCCTGCAGACCTGGCTTCTGAACCGCTACCGCATGGTGCAG
CTGGAGCCCATTGACCAGGTGGTCCTGTCCTACGGGGGCCTGCGCGGGGCCGTGGCCTTT
GCCCTGGTGGTGCTTCTGGATGGAGACAAGGTCAAGGAGAAGAACCTGTTCGTCAGCACC
ACCATCATCGTAGTGTTCTTCACCGTCATCTTCCAGGGCCTGACCATCAAGCCTCTGGTG
CAGTGGCTGAAGGTGAAGAGGAGCGAGCACCGGGAACCTCGGCTCAACGAGAAGCTGCAC
GGCCGCGCTTTCGACCACATCCTCTCGGCCATCGAGGACATATCCGGACAGATCGGGCAC
AATTATCTCAGAGACAAGTGGTCCCACTTCGACAGGAAGTTCCTCAGCAGGGTCCTCATG
AGACGGTCGGCCCAGAAGTCTCGAGACCGGATCCTGAATGTCTTCCACGAGCTGAACCTG
AAGGATGCCATCAGCTACGTGGCTGAGGGAGAGCGCCGCGGGTCCCTGGCCTTCATCCGC
TCCCCCAGCACCGACAACGTGGTCAACGTGGACTTCACGCCACGATCGTCCACCGTGGAG
GCCTCTGTCTCCTACCTCCTGAGAGAAAATGTCAGCGCTGTCTGCCTGGACATGCAGTCT
CTGGAGCAGCGACGGCGGAGCATCCGGGACGCGGAGGACATGGTCACGCACCACACGCTA
CAGCAGTACCTGTACAAGCCGCGGCAGGAGTACAAGCATCTGTACAGCCGACACGAGCTC
ACGCCCACGGAGGACGAGAAACAGGACCGGGAAATCTTCCACAGGACCATGCGGAAGCGC
CTGGAGTCCTTCAAGTCGACCAAGCTGGGGCTCAACCAGAACAAGAAGGCAGCCAAGCTG
TACAAGCGGGAGCGTGCCCAGAAGCGGAGAAACAGCAGCATCCCCAATGGGAAGCTGCCC
ATGGAGAGCCCTGCGCAGAATTTCACCATCAAGGAGAAAGACTTGGAACTTTCAGACACC
GAGGAGCCCCCCAACTATGATGAGGAGATGAGTGGGGGGATCGAGTTCCTGGCTAGTGTC
ACCAAGGACACAGCGTCCGACTCCCCTGCAGGAATTGACAACCCTGTGTTTTCTCCGGAC
GAGGCCCTGGACCGCAGCCTCCTGGCCAGGCTGCCGCCCTGGCTGTCTCCCGGGGAGACG
GTGGTCCCCTCGCAGAGGGCCCGCACGCAGATTCCCTACTCTCCCGGCACCTTCCGCCGC
CTGATGCCCTTCCGCCTCAGCAGCAAGTCCGTGGACTCCTTCCTGCAGGCAGACGGCCCC
GAGGAGCGGCCCCCCGCCGCCCTCCCCGAGTCCACACACATGTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
U28043

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_1_Locus:
5p15.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs3777231; rs6870920; rs9885312; rs2230437; rs3777230; rs12657631; rs6555316; rs6864158; rs6891049; rs890979; rs10475279; rs4957059; rs2278252; rs3734141; rs6868535; rs10475268; rs12716164; rs890980; rs6891064; rs4345352; rs11748526; rs2241597; rs11746573; rs13165421; rs890985; rs11134081; rs10078774; rs4957061; rs2434389; rs2278254; rs13357643; rs890983; rs11134071; rs9764991; rs6879352; rs2244240; rs890981; rs12716163; rs10475276; rs13158034; rs3777234; rs890978; rs12652789; rs4263057; rs4957045; rs12522575; rs11738544; rs2244223; rs2278247; rs6869648; rs11134082; rs890984; rs925693; rs11134072; rs11134080; rs4956940; rs6555317; rs11740933; rs11743305; rs10475282; rs2247107; rs11134078; rs3777233; rs13436079; rs3756711; rs7443244; rs6872510; rs10462621; rs890977; rs2434377; rs11746373; rs12109836; rs12716166; rs4957043; rs3777226; rs12657794; rs7709376; rs6872583; rs13153157; rs3836908; rs4956947; rs13436080; rs11950405; rs3734137; rs6882664; rs11747348; rs10076162; rs12520842; rs12716167; rs4245971; rs12519017; rs3734139; rs2458820; rs4956949; rs12515615; rs890986; rs6869782; rs7444581; rs10475269; rs12521198; rs11957707; rs10475280; rs11955160; rs3734138; rs11748410; rs4957044; rs6892166; rs2303736; rs4502351; rs6894329; rs9885589; rs6859852; rs4271701; rs13359853; rs10462622; rs3836909; rs7445979; rs17563161; rs6420045; rs2458814; rs1043356; rs12521236; rs6869609; rs13177896; rs890976; rs4956939; rs6879351; rs7721583; rs6555303; rs13356700; rs11950404; rs890982; rs6863511; rs1560173; rs10475283; rs890973; rs1053247; rs13154302; rs41282627; rs3777232; rs34257190; rs41282629; rs36074164; rs34939525; rs35054464; rs34644402; rs10073235; rs34275631; rs11745923; rs4334924; rs28590222; rs7718175; rs34022500; rs35604682; rs28419449; rs12188162; rs36213761; rs35873489; rs10580563; rs7704351; rs7380218; rs4957046; rs10076947; rs35941359; rs12516111; rs5865334; rs34168120; rs10659788; rs34362833; rs13173342; rs11747879; rs7733384; rs33927212; rs4957042; rs11739047; rs13154119; rs36019395; rs35784759; rs34701766; rs34719061; rs12054954; rs11385632; rs34820209; rs34121997; rs34154349; rs41282631; rs10475270; rs6889955; rs34537509; rs10572355; rs7713070; rs11743825; rs4957047; rs33992584; rs938324; rs7378626; rs13170444; rs4957060; rs35227727; rs2303735; rs36161633; rs7725551; rs13359721; rs35697323; rs35710918; rs7445970; rs34406484; rs11950353; rs6555324; rs35600787; rs10078684; rs11338472; rs2458819; rs13360817; rs10053300; rs5865333; rs6888815; rs34293895; rs11741234; rs3734140; rs13168935; rs11955896; rs3211145; rs13152890; rs34562440; rs7736622; rs34834059; rs35878814; rs35145443; rs10062053; rs35346581; rs10065644; rs34033998; rs35159055; rs4520963; rs35051913; rs13186188; rs35858723; rs33925304; rs11954611; rs2721030; rs10475275; rs10551484; rs12188556; rs13174780; rs13359797; rs2303737; rs36083128; rs10475271; rs34004700; rs11385633; rs4956948; rs3832380; rs36124859; rs36160359; rs11747491; rs11956075; rs11269302; rs7735595; rs13181243; rs35715105; rs13189685; rs35671785; rs10067184; rs12109483; rs3214559; rs34590639; rs28619154; rs41282625; rs2278253; rs34160944; rs34358734; rs2303734; rs12110079; rs35004250; rs2560732; rs7700827; rs2672029; rs7723049; rs33997355; rs10073165; rs1035908; rs1035909; rs10474780; rs1053226; rs1053233; rs1053257; rs1053299; rs11169; rs1139706; rs13162508; rs2247114; rs2434695; rs2434697; rs2561667; rs2561676; rs2672028; rs2672032; rs2721014; rs3315; rs36111336; rs3777225; rs3815928; rs3815929; rs3853656; rs3867180; rs3915786; rs4591794; rs4957063; rs6896261; rs699644; rs7726057; rs772659; rs890974

# Macromolecular_Interacting_Partner_1_General_References:
7631746

# Macromolecular_Interacting_Partner_1_References:
15082449

# Macromolecular_Interacting_Partner_2_ID:
8363

# Macromolecular_Interacting_Partner_2_Name:
Solute carrier family 26 member 6

# Macromolecular_Interacting_Partner_2_Synonyms:
Pendrin-like protein 1; Pendrin L1

# Macromolecular_Interacting_Partner_2_Gene_Name:
SLC26A6

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Solute carrier family 26 member 6
MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL
QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV
FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR
VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS
SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL
TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI
SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA
ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT
FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV
KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ
AASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKA
LGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGH
FFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
759

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
82968

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
8.52

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  transporter activity
Function:  ion transporter activity
Function:  anion transporter activity
Function:  inorganic anion transporter activity
Function:  sulfate transporter activity
Function:  sulfate porter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  sulfate transport
 ||
>>>
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_2_Specific_Function:
Does not seem to be involved in anion transport

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF01740:STAS;
PF00916:Sulfate_transp

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
115-137
187-209
264-284
295-314
346-368
380-400
417-437
443-460
485-505

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
13344999

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
S26A6_HUMAN (Q9BXS9)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
SLC26A6

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
SLC26A6

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:14472

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>2280 bp
ATGGGGCTGGCGGATGCGTCGGGACCGAGGGACACACAGGCACTGCTGTCTGCAACACAA
GCAATGGACCTGCGGAGGCGAGACTACCACATGGAACGGCCGCTGCTGAACCAGGAGCAT
TTGGAGGAGCTGGGGCGCTGGGGCTCAGCACCTAGGACCCACCAGTGGCGGACCTGGTTG
CAGTGCTCCCGTGCTCGGGCCTATGCCCTTCTGCTCCAACACCTCCCGGTTTTGGTCTGG
TTACCCCGGTATCCTGTGCGTGACTGGCTCCTGGGTGACCTGTTATCCGGCCTGAGTGTG
GCCATCATGCAGCTTCCGCAGGGCTTGGCCTACGCCCTCCTGGCTGGATTGCCCCCCGTG
TTTGGCCTCTATAGCTCCTTCTACCCTGTCTTCATCTACTTCCTGTTTGGCACTTCCCGG
CACATCTCCGTGGGGACCTTTGCTGTCATGTCTGTGATGGTGGGCAGTGTGACAGAATCC
CTGGCCCCGCAGGCCTTGAACGACTCCATGATCAATGAGACAGCCAGAGATGCTGCCCGG
GTACAGGTGGCCTCCACACTCAGTGTCCTGGTTGGCCTCTTCCAGGTGGGGCTGGGCCTG
ATCCACTTCGGCTTCGTGGTCACCTACCTGTCAGAACCTCTTGTCCGAGGCTATACCACA
GCTGCAGCTGTGCAGGTCTTCGTCTCACAGCTCAAGTATGTGTTTGGCCTCCATCTGAGC
AGCCACTCTGGGCCACTGTCCCTCATCTATACAGTGCTGGAGGTCTGCTGGAAGCTGCCC
CAGAGCAAGGTTGGCACCGTGGTCACTGCAGCTGTGGCTGGGGTGGTGCTCGTGGTGGTG
AAGCTGTTGAATGACAAGCTGCAGCAGCAGCTGCCCATGCCGATACCCGGGGAGCTGCTC
ACGCTCATCGGGGCCACAGGCATCTCCTATGGCATGGGTCTAAAGCACAGATTTGAGGTA
GATGTCGTGGGCAACATCCCTGCAGGGCTGGTGCCCCCAGTGGCCCCCAACACCCAGCTG
TTCTCAAAGCTCGTGGGCAGCGCCTTCACCATCGCTGTGGTTGGGTTTGCCATTGCCATC
TCACTGGGGAAGATCTTCGCCCTGAGGCACGGCTACCGGGTGGACAGCAACCAGGAGCTG
GTGGCCCTGGGCCTCAGTAACCTTATCGGAGGCATCTTCCAGTGCTTCCCCGTGAGTTGC
TCTATGTCTCGGAGCCTGGTACAGGAGAGCACCGGGGGCAACTCGCAGGTTGCTGGAGCC
ATCTCTTCCCTTTTCATCCTCCTCATCATTGTCAAACTTGGGGAACTCTTCCATGACCTG
CCCAAGGCGGTCCTGGCAGCCATCATCATTGTGAACCTGAAGGGCATGCTGAGGCAGCTC
AGCGACATGCGCTCCCTCTGGAAGGCCAATCGGGCGGATCTGCTTATCTGGCTGGTGACC
TTCACGGCCACCATCTTGCTGAACCTGGACCTTGGCTTGGTGGTTGCGGTCATCTTCTCC
CTGCTGCTCGTGGTGGTCCGGACACAGATGCCCCACTACTCTGTCCTGGGGCAGGTGCCA
GACACGGATATTTACAGAGATGTGGCAGAGTACTCAGAGGCCAAGGAAGTCCGGGGGGTG
AAGGTCTTCCGCTCCTCGGCCACCGTGTACTTTGCCAATGCTGAGTTCTACAGTGATGCG
CTGAAGCAGAGGTGTGGTGTGGATGTCGACTTCCTCATCTCCCAGAAGAAGAAACTGCTC
AAGAAGCAGGAGCAGCTGAAGCTGAAGCAACTGCAGAAAGAGGAGAAGCTTCGGAAACAG
GCTGCCTCCCCCAAGGGCGCCTCAGTTTCCATTAATGTCAACACCAGCCTTGAAGACATG
AGGAGCAACAACGTTGAGGACTGCAAGATGATGCAGGTGAGCTCAGGAGATAAGATGGAA
GATGCAACAGCCAATGGTCAAGAAGACTCCAAGGCCCCAGATGGGTCCACACTGAAGGCC
CTGGGCCTGCCTCAGCCAGACTTCCACAGCCTCATCCTGGACCTGGGTGCCCTCTCCTTT
GTGGACACTGTGTGCCTCAAGAGCCTGAAGAATATTTTCCATGACTTCCGGGAGATTGAG
GTGGAGGTGTACATGGCGGCCTGCCACAGCCCTGTGGTCAGCCAGCTTGAGGCTGGGCAC
TTCTTCGATGCATCCATCACCAAGAAGCATCTCTTTGCCTCTGTCCATGATGCTGTCACC
TTTGCCCTCCAACACCCGAGGCCTGTCCCCGACAGCCCTGTTTCGGTCACCAGACTCTGA


# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AF288410

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_2_Locus:
3p21.3

# Macromolecular_Interacting_Partner_2_SNPs:
rs13324142; rs2276849; rs2310996; rs740787; rs2276852; rs7620853; rs3821876; rs2276851; rs3806694; rs758636; rs2276850; rs7631574; rs13063312; rs13084591; rs35502472; rs35186335; rs11459984; rs34368826; rs6762570; rs6763049; rs10595496; rs34388752; rs35939210; rs11720272; rs1264195; rs2270155; rs2310997; rs34581457; rs34638686; rs3895736; rs6773261; rs6791777; rs6792156; rs6809205; rs9811378; rs9868809; rs9878063

# Macromolecular_Interacting_Partner_2_General_References:
11247665

# Macromolecular_Interacting_Partner_2_References:
15574486; 17151144

# Macromolecular_Interacting_Partner_3_ID:
8549

# Macromolecular_Interacting_Partner_3_Name:
Pendrin

# Macromolecular_Interacting_Partner_3_Synonyms:
Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC26A4

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Pendrin
MAAPGGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKR
AFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSA
FFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAA
RDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVL
NVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPI
PIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVA
YAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKT
QVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAV
IWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIE
EPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRAT
KNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVL
DCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFL
TVHDAILYLQNQVKSQEGQGSILETITLIQDCKDTLELIETELTEEELDVQDEAMRTLAS


# Macromolecular_Interacting_Partner_3_Number_of_Residues:
780

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
85724

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.29

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
 Function:  transporter activity
Function:  ion transporter activity
Function:  anion transporter activity
Function:  inorganic anion transporter activity
Function:  sulfate transporter activity
Function:  sulfate porter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  sulfate transport
 ||
>>>
 Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Sodium-independent transporter of chloride and iodide

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF01740:STAS
PF00916:Sulfate_transp

# Macromolecular_Interacting_Partner_3_Signals:
Not Available

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
110-130
136-156
192-212
264-284
296-316
345-365
385-405
422-442
449-469
487-507
653-673

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
S26A4_HUMAN (O43511)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC26A4

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC26A4

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:8818

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; multi-pass membrane protein (Probable)

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF030880

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_3_Locus:
7q31

# Macromolecular_Interacting_Partner_3_SNPs:
rs17154335; rs35548413; rs17154353; rs36039758; rs34373141; rs17154347; rs7811324; rs2712218; rs17154282; rs1858929; rs982915; rs982663; rs2701687; rs2395911; rs2237679; rs2712207; rs6466178; rs2072065; rs10276013; rs1989837; rs7796307; rs2072064; rs3823957; rs6970857; rs916730; rs7799849; rs2712208; rs1858930; rs3801940; rs6961725; rs10241330; rs2248465; rs6974721; rs6953220; rs6975897; rs10250391; rs10250105; rs13232692; rs16872367; rs3817613; rs2701688; rs11769313; rs7782467; rs2712212; rs3801943; rs6949189; rs7797202; rs6955309; rs13245080; rs7781603; rs16872356; rs7781599; rs10233087; rs17154331; rs11978514; rs6954797; rs12705418; rs10261745; rs7777472; rs13231647; rs2701686; rs6947785; rs2712211; rs11973872; rs2395910; rs2248464; rs6974479; rs2712210; rs11971720; rs7777227; rs6954570; rs12535992; rs10273002; rs17154292; rs982664; rs11768062; rs3823956; rs2712227; rs2072063; rs7781918; rs10234822; rs17154285; rs7781747; rs2188562; rs7777836; rs10273003; rs11978515; rs6943886; rs2301634; rs10275646; rs17154326; rs10253447; rs2188561; rs2712228; rs2701685; rs2701684; rs34942046; rs35045430; rs17154362; rs2712205; rs28528104; rs34505430; rs35493944; rs36039373; rs34443296; rs34832295; rs2712209; rs2395917; rs6150277; rs28549206; rs35575419; rs34861609; rs2395916; rs28566998; rs7784294; rs35349410; rs35766469; rs13232094; rs34296784; rs34538469; rs36069731; rs34694220; rs35019739; rs2701690; rs2701689; rs13311385; rs11771988; rs34259163; rs10690223; rs34704782; rs35161285; rs11761887; rs28706204; rs34557053; rs6942406; rs13311388; rs28640899; rs2395914; rs13221662; rs34431815; rs5886421; rs10701870; rs12533632; rs6965410; rs982662; rs11462799; rs28605840; rs35129421; rs13231630; rs2395913; rs7777921; rs34322584; rs9770946; rs11274185; rs3839817; rs11335507; rs13310984; rs2395912; rs956788; rs11771985; rs10626659; rs34850943; rs2395918; rs35800436; rs34952869; rs28717031; rs35202314; rs13234584; rs34424730; rs7777001; rs28769984; rs3076001; rs2395915; rs34812572; rs35995980; rs13244296; rs35594479; rs10240818; rs28398227; rs10271911; rs11542790; rs10235244; rs10235446; rs10235452; rs10265205; rs10275626; rs10480449; rs11762699; rs11763508; rs11972418; rs11977213; rs12667481; rs2028030; rs2701683; rs2712229; rs2712230; rs34405835; rs35731424; rs4730252; rs4730253; rs7788450; rs7789746; rs7790876; rs7795731; rs929200

# Macromolecular_Interacting_Partner_3_General_References:
9398842; 12853948; 10192399; 9618166; 9618167; 9500541; 10190331; 10602116; 10878664; 10700480; 11375792; 11317356; 11748854; 12112665; 11932316; 11919333; 12788906; 12676893

# Macromolecular_Interacting_Partner_3_References:
Not Available

End of HMDB00142

Beginning of HMDB00143
# Accession_No:
HMDB00143

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-23 16:30:16

# biospider_lastupdate:
2007-07-25 09:23:37

# Common_Name:
D-Galactose

# Description:
An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.

# Synonyms:
(+)-Galactose; D-(+)-Galactose; D-Galactose; Alpha-d-galactopyranose; Alpha d-galactose; GLA; GAL; Hexose; Alpha-d-galactose; Galactose; GLC

# Chemical_IUPAC_Name:
D-Galactose

# Chemical_Formula:
C6H12O6

# Chemical_Structure:
tbl_chemical:::HMDB00143_ZOOM.png:::119283214894255278

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00143_THUMB.png:::119283214735522409

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Carbohydrates

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiacetal; primary alcohol; secondary alcohol; 1,2-diol; heterocyclic compound

# Taxonomy_Biofunction:
Component of Galactose metabolism; Component of Glycerolipid metabolism; Component of Glycosphingolipid metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
180.06339

# Molecular_Weight_Avg:
180.15588

# Smiles_String_isomeric:
OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O

# Smiles_String_canonical:
OCC1OC(O)C(O)C(O)C1O

# KEGG_Compound_ID:
C00124

# BioCyc_ID:
GALACTOSE

# PubChem_CID:
439357

# PubChem_SID:
837254; 830571; 836035; 830801; 837890; 836258; 838760; 14968276; 823284; 833476; 833368; 8026739; 833295; 24698349; 828584; 831011; 8022578; 826572; 819698; 838212; 829545; 834926; 819701; 836778; 839013; 17422105; 834474; 827887; 4738; 821847; 14719913; 824183; 836623; 22394713; 24778773; 585631; 830219; 832269; 834642; 831485; 855128; 826579; 3424; 24698347; 827886; 826575; 24874892; 819737; 828763; 825450; 14719909; 7887757; 833137; 8004582; 17422243; 836782; 836556; 833133; 822032; 826583; 828594; 831102; 825231; 855047; 7887845; 4231; 830975; 827891; 24874901; 17422277; 833142; 830813; 11110371; 826586; 14717692; 12055836; 10298309; 827914

# OMIM_ID:
137030; 212065; 227810; 229500; 230350; 230400

# Metagene_ID:
FANCONI-BICKEL SYNDROME: 436; GALACTOSEMIA: 136; GALACTOSEMIA II (GALK): 134; GALACTOSEMIA III: 139; PATENT DUCTUS VENOSUS: 460; GLUCOSE-GALACTOSE MALABSORPTION: 150

# BiGG_ID:
33945

# Wikipedia_ID:
Not Available

# METLIN_ID:
134

# Ref_ID:
11112850; 12470678; 10429957; 10794741; 10679984; 11256998; 11855872; 10365579; 15295082; 11506413; 10210915; 15118981; 15115252; 7843709; 11901058; 11079200; 12097436; 11092512; 10926297; 2026685; 16456418; 7805025; 6478; 11753045; 15188975

# ChEBI_ID:
12936; 28061

# CAS_Registry_Number:
59-23-4

# InChI:
InChI=1/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6+/m1/s1

# Synthesis_Reference:
Synthesis of D-galactose-6-t and D-galactosides-6-t.     Avigad, Gad.    Hebrew Univ.,  Jerusalem,  Israel.    Carbohydrate Research  (1967),  3(4),  430-4.

# Melting_Point:
170 oC

# Melting_Point_predicted:
106.2 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
683.0 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
782.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.57 [Predicted by ALOGPS]; -2.3 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::D-(+)-Galactose.pdf:::1132562205807666899

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00143.mol:::117503915035851539

# SDF_File_[Text]:
tbl_chemical:::HMDB00143.sdf:::119283214337640567

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00143.pdb:::119283214595776108

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041024_P00_05_HW_1DP_PRESAT_expanded_2.gif:::114460741777610382

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041024_P00_05_HW_1DP_presat.zip:::1177710623137125545

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041024_P00_05_HW_assigned.png:::11921411578339967

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041024_P00_05_HW_1DP_Presat.png:::115877568490325750

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041024_P00_05_HW_1DP_Presat.zip:::115877568492154805

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041024_P00_05_HW_1DP_Assigned.png:::116551625053122931

# C_NMR_Spectra:
tbl_cnmr:::041024_P00_05_HW_1DC_45.jpg:::114168459801223741

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041024_P00_05_HW_1DC_45.zip:::114168459797254398

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041024_P00_05_HW_1DC_45_Assigned.jpg:::114659319073437031

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041024_P00_05_HW_2DHSQC_134.jpg:::114495803044774340

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041024_P00_05_HW_2DHSQC_134.zip:::114495803077346653

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041024_P00_05_HW_2DHSQC_134_Assigned.jpg:::115982393503631570

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Galactose.gif:::11660332321322291

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00143_peaks.txt:::116603323215933491

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Galactose_C.gif:::116603327750269841

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00143_peaks.txt:::116603327748669036

# Mass_Spectrum:
tbl_chemical:::HMDB00143.gif:::117350048259535734

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000013.png:::116899930754667404

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000013.txt:::116899930753126008

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000013.png:::11689082223125745

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000013.txt:::11689082228287435

# Cellular_Location:
Cytoplasm (Predicted from LogP); Extracellular; lysosome

# Tissue_Location:
Brain; Liver

# deuterated:
No

# Biofluid_Location:
Bile; Blood; Breast Milk; CSF; Cellular Cytoplasm; Feces; Mucus; Saliva

# Concentration_[Normal]:
Blood	210.0 +/- 92.0	uM	Children:1-13_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	88.3 +/- 34.7	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	39.0 +/- 12.0	uM	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	0.0-5.0	umol/L	Adult:>18_yrs_old	Both	Normal	14988808	
Cerebrospinal_Fluid(CSF)	166.0 +/- 99.0	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Saliva	>10	umol/L	Adult:>18_yrs_old	Both	Normal	12097436
Cellular_Cytoplasm	4.6 (0.0-9.2)	uM	Children:1-13_yrs_old	Both	Normal	11901058


# Concentration_[Abnormal]:
Blood	2.72 +/- 0.70 	uM	Infant:0-1_yr_old	Both	Classical Galactosemia	11092512
Cellular_Cytoplasm	1496.5 (921.0 - 2070)	uM	Children:1-13_yrs_old	Both	Galactosemia	11901058


# Associated_Disorders:
Classical Galactosemia; Galactosemia; Galactosemia II (galk): increased; Galactosemia III; Glucose-Galactose Malabsorption; Patent Ductus Venosus; Premature Ovarian Failure

# Pathway_Names:
Galactose metabolism;Glycerolipid metabolism;Glycosphingolipid metabolism

# Pathway_Images:
;;

# KEGG_Images:
map00052;map00561;map00600

# Pathway_Graphs:
;;

# Pathway_SBMLs:
;;

# Metabolic_Enzyme_1_ID:
6124

# Metabolic_Enzyme_1_Name:
Beta-galactosidase precursor

# Metabolic_Enzyme_1_Synonyms:
Lactase; Acid beta- galactosidase

# Metabolic_Enzyme_1_Gene_Name:
GLB1

# Metabolic_Enzyme_1_Protein_Sequence:
>Betagalactosidase precursor
MPGFLVRILLLLLVLLLLGPTRGLRNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRV
PRFYWKDRLL
KMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVI
LRPGPYICAEWEMGGLPAWLL
EKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGG
PVITVQVENEYGSYFACDFDYLRFLQKRFRHH
LGDDVVLFTTDGAHKTFLKCGALQGLY
TTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQP
HSTIKTEAVASSLYDI
LARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFAL
RNIIQ
KFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGF
VLYRT
TLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLD
LLVENMGRVNYGAYIN
DFKGLVSNLTLSSNILTDWTIFPLDTEDAVRSHLGGWGHRDSG
HHDEAWAHNSSNYTLPAFYMGNFSIPS
GIPDLPQDTFIQFPGWTKGQVWINGFNLGRYW
PARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDD
PELCAVTFVDRPVIGSSVTYD
HPSKPVEKRLMPPPPQKNKDSWLDHV

# Metabolic_Enzyme_1_Number_of_Residues:
677

# Metabolic_Enzyme_1_Molecular_Weight:
76092

# Metabolic_Enzyme_1_Theoretical_pI:
6.55

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  galactosidase activity
Function:  beta-galactosidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  protein complex
Component:  unlocalized protein complex
Component:  beta-galactosidase complex

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans

# Metabolic_Enzyme_1_Pathway:
map00052  Galactose metabolism;
 map00511  N-Glycan degradation;
 map00531  Glycosaminoglycan degradation;
 map00561  Glycerolipid metabolism;
 map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_1_Reaction:
Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01301:Glyco_hydro_35

# Metabolic_Enzyme_1_Signals:
1-23

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.2.1.23

# Metabolic_Enzyme_1_GenBank_ID_Protein:
179401

# Metabolic_Enzyme_1_SwissProt_ID:
BGAL_HUMAN (P16278)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
GLB1

# Metabolic_Enzyme_1_Geneatlas_id:
GLB1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4298

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_1_Gene_Sequence:
>2034 bp

ATGCCGGGGTTCCTGGTTCGCATCCTCCTTCTGCTGCTGGTTCTGCTGCTTCTGGGCCC
TACGCGCGGCT
TGCGCAATGCCACCCAGAGGATGTTTGAAATTGACTATAGCCGGGACT
CCTTCCTCAAGGATGGCCAGCC
ATTTCGCTACATCTCAGGAAGCATTCACTACTCCCGT
GTGCCCCGCTTCTACTGGAAGGACCGGCTGCTG
AAGATGAAGATGGCTGGGCTGAACGC
CATCCAGACGTATGTGCCCTGGAACTTTCATGAGCCCTGGCCAG
GACAGTACCAGTTTT
CTGAGGACCATGATGTGGAATATTTTCTTCGGCTGGCTCATGAGCTGGGACTGCT
GGTT
ATCCTGAGGCCCGGGCCCTACATCTGTGCAGAGTGGGAAATGGGAGGATTACCTGCTTGG
CTGCTA
GAGAAAGAGTCTATTCTTCTCCGCTCCTCCGACCCAGATTACCTGGCAGCTGT
GGACAAGTGGTTGGGAG
TCCTTCTGCCCAAGATGAAGCCTCTCCTCTATCAGAATGGAG
GGCCAGTTATAACAGTGCAGGTTGAAAA
TGAATATGGCAGCTACTTTGCCTGTGATTTT
GACTACCTGCGCTTCCTGCAGAAGCGCTTTCGCCACCAT
CTGGGGGATGATGTGGTTCT
GTTTACCACTGATGGAGCACATAAAACATTCCTGAAATGTGGGGCCCTGC
AGGGCCTCT
ACACCACGGTGGACTTTGGAACAGGCAGCAACATCACAGATGCTTTCCTAAGCCAGAGGA
A
GTGTGAGCCCAAAGGACCCTTGATCAATTCTGAATTCTATACTGGCTGGCTAGATCAC
TGGGGCCAACCT
CACTCCACAATCAAGACCGAAGCAGTGGCTTCCTCCCTCTATGATAT
ACTTGCCCGTGGGGCGAGTGTGA
ACTTGTACATGTTTATAGGTGGGACCAATTTTGCCT
ATTGGAATGGGGCCAACTCACCCTATGCAGCACA
GCCCACCAGCTACGACTATGATGCC
CCACTGAGTGAGGCTGGGGACCTCACTGAGAAGTATTTTGCTCTG
CGAAACATCATCCA
GAAGTTTGAAAAAGTACCAGAAGGTCCTATCCCTCCATCTACACCAAAGTTTGCAT
ATG
GAAAGGTCACTTTGGAAAAGTTAAAGACAGTGGGAGCAGCTCTGGACATTCTGTGTCCCT
CTGGGCC
CATCAAAAGCCTTTATCCCTTGACATTTATCCAGGTGAAACAGCATTATGGG
TTTGTGCTGTACCGGACA
ACACTTCCTCAAGATTGCAGCAACCCAGCACCTCTCTCTTC
ACCCCTCAATGGAGTCCACGATCGAGCAT
ATGTTGCTGTGGATGGGATCCCCCAGGGAG
TCCTTGAGCGAAACAATGTGATCACTCTGAACATAACAGG
GAAAGCTGGAGCCACTCTG
GACCTTCTGGTAGAGAACATGGGACGTGTGAACTATGGTGCATATATCAAC
GATTTTAA
GGGTTTGGTTTCTAACCTGACTCTCAGTTCCAATATCCTCACGGACTGGACGATCTTTCC
AC
TGGACACTGAGGATGCAGTGCGCAGCCACCTGGGGGGCTGGGGACACCGTGACAGTG
GCCACCATGATGA
AGCCTGGGCCCACAACTCATCCAACTACACGCTCCCGGCCTTTTAT
ATGGGGAACTTCTCCATTCCCAGT
GGGATCCCAGACTTGCCCCAGGACACCTTTATCCA
GTTTCCTGGATGGACCAAGGGCCAGGTCTGGATTA
ATGGCTTTAACCTTGGCCGCTATT
GGCCAGCCCGGGGCCCTCAGTTGACCTTGTTTGTGCCCCAGCACAT
CCTGATGACCTCG
GCCCCAAACACCATCACCGTGCTGGAACTGGAGTGGGCACCCTGCAGCAGTGATGAT
CC
AGAACTATGTGCTGTGACGTTCGTGGACAGGCCAGTTATTGGCTCATCTGTGACCTACGA
TCATCCCT
CCAAACCTGTTGAAAAAAGACTCATGCCCCCACCCCCGCAAAAAAACAAAG
ATTCATGGCTGGACCATGT
ATGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M27507

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_1_Locus:
3p21.33

# Metabolic_Enzyme_1_SNPs:
rs4302331; rs35289681; rs4645101; rs6805519; rs7614585; rs3924695; rs4679075; rs9869052; rs4350874; rs6550204; rs4479543; rs9827863; rs9868526; rs4277638; rs6550200; rs4679074; rs6780220; rs7613051; rs6781225; rs6777787; rs4438612; rs6550203; rs9828592; rs4423716; rs7616912; rs7629880; rs4679082; rs4320035; rs9311003; rs9310999; rs6550202; rs6802807; rs6766207; rs3924696; rs6805766; rs4678613; rs6781531; rs6766191; rs4074708; rs6550191; rs13078132; rs9311001; rs4528891; rs4402881; rs4234266; rs7637435; rs6550205; rs4130167; rs9863198; rs9875798; rs12632196; rs6782510; rs9849898; rs1133253; rs4234262; rs9833676; rs11708012; rs9865921; rs9311002; rs4678868; rs4678660; rs12635761; rs9826234; rs11715310; rs6762132; rs7646283; rs9310998; rs10154834; rs11707667; rs13093517; rs4678657; rs11129544; rs4270461; rs9861960; rs11714207; rs12633904; rs13314478; rs7643224; rs12495572; rs4328758; rs13093698; rs4679076; rs9883177; rs13080709; rs4274702; rs6550199; rs11129542; rs9810375; rs11717007; rs11712996; rs4343578; rs6773715; rs9858362; rs9815409; rs13078515; rs13096312; rs4679077; rs6785135; rs9861316; rs13324134; rs4257495; rs11718295; rs9852589; rs4234267; rs9824270; rs9816051; rs9860199; rs9866187; rs7626612; rs9831065; rs9868815; rs9852081; rs7610177; rs4311175; rs9865232; rs9817993; rs9882717; rs9824218; rs7616228; rs6770187; rs9819337; rs4493381; rs6768988; rs7618005; rs4575834; rs12054351; rs35000357; rs6776757; rs13081593; rs4263242; rs9827128; rs6770614; rs13078446; rs9883376; rs4998983; rs11706136; rs9830701; rs4678652; rs7628722; rs4269037; rs6783481; rs7610270; rs4491851; rs13094148; rs6769803; rs9845011; rs12491500; rs6805872; rs9851902; rs9860184; rs9754700; rs6770682; rs9838286; rs9840748; rs9810955; rs9829197; rs11129543; rs12490111; rs4679097; rs9872578; rs4558698; rs9814670; rs9841000; rs34173901; rs4456812; rs9858291; rs11924625; rs4383462; rs4630893; rs6782297; rs4583587; rs4678644; rs6786613; rs7610916; rs7650543; rs11720449; rs4547648; rs9865113; rs11707205; rs7645956; rs34103134; rs4428129; rs11927929; rs4371463; rs13079353; rs4234264; rs11713054; rs6769787; rs9849213; rs9851459; rs12633200; rs9817393; rs6782318; rs9880004; rs9863331; rs12167; rs7643313; rs4678523; rs4678524; rs1803198; rs13073546; rs1803199; rs34421970; rs1803200; rs34204221; rs6776436; rs35360222; rs35516563; rs35949170; rs35217324; rs34064757; rs9681623; rs35066652; rs9879174; rs28457681; rs35366996; rs12636380; rs35546490; rs4411834; rs34170794; rs34840292; rs11706680; rs35079906; rs35567563; rs35096418; rs34190372; rs34267899; rs9835090; rs34542942; rs28564715; rs34783720; rs35299531; rs28752078; rs35609083; rs4404396; rs10596366; rs36061528; rs35625458; rs6550190; rs4678642; rs35791447; rs35543972; rs10702620; rs7612742; rs11387959; rs9875140; rs9858992; rs28538948; rs4472006; rs34081225; rs35480293; rs11443960; rs34301631; rs34629244; rs9836304; rs4678941; rs9825789; rs11927839; rs35111870; rs35849739; rs34459243; rs6767833; rs7431645; rs10683710; rs28488329; rs9825335; rs35781117; rs9872225; rs34491679; rs13077125; rs9858364; rs11342344; rs35553546; rs35894066; rs10559091; rs35313892; rs6800001; rs13079744; rs13062239; rs10662168; rs6772595; rs13059918; rs34558646; rs28615536; rs11303788; rs10679653; rs36181668; rs35688004; rs11414853; rs7610165; rs35269925; rs11348689; rs34388197; rs11459888; rs9852362; rs4678643; rs4130168; rs11328798; rs7621255; rs11276167; rs11915291; rs28727973; rs13092698; rs34500490; rs36036446; rs7610931; rs35201739; rs6785862; rs11428956; rs11385614; rs4234263; rs7619312; rs11717735; rs34139339; rs34827860; rs6776437; rs6770268; rs12054117; rs34097913; rs11416783; rs35555652; rs36140454; rs9848784; rs10613912; rs35419837; rs35291321; rs4613407; rs34772446; rs35570272; rs7650438; rs6792048; rs11289119; rs11707202; rs7646643; rs35879433; rs35844867; rs28420683; rs28617702; rs34103242; rs35684962; rs34958264; rs9845695; rs34986791; rs35533674; rs34652262; rs7628609; rs35507451; rs35777526; rs35835691; rs4298001; rs35847345; rs35580094; rs28372666; rs34648323; rs13098058; rs9865342; rs34547154; rs35399363; rs35548830; rs9811260; rs34925031; rs4130166; rs10661628; rs9849872; rs35026670; rs13072499; rs34482863; rs4447709; rs4508727; rs12487241; rs9831194; rs13082782; rs10529787; rs13314904; rs4234234; rs9873651; rs5847772; rs11423270; rs9850839; rs10528005; rs35809982; rs9838124; rs4678849; rs11711396; rs11715480; rs11718846; rs11914868; rs12635828; rs4075736; rs4578976; rs4678677; rs4678774; rs6769735; rs6793913; rs7612234; rs7614776; rs9860567

# Metabolic_Enzyme_1_General_References:
2511208; 2111707; 3143362; 10841810; 10571006; 1928092; 1909089; 1907800; 1487238; 8213816; 8198123; 7586649; 9203065; 12393180; 10338095; 10839995; 10737981; 11511921

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6126

# Metabolic_Enzyme_2_Name:
Ceramide glucosyltransferase

# Metabolic_Enzyme_2_Synonyms:
Glucosylceramide synthase; GCS; UDP-glucose:N-acylsphingosine D-glucosyltransferase; UDP- glucose ceramide glucosyltransferase; GLCT-1

# Metabolic_Enzyme_2_Gene_Name:
UGCG

# Metabolic_Enzyme_2_Protein_Sequence:
>Ceramide glucosyltransferase
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLK
GVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVG
INPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGF
AATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMA
KAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVAS
LIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMT
IYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV

# Metabolic_Enzyme_2_Number_of_Residues:
394

# Metabolic_Enzyme_2_Molecular_Weight:
44854

# Metabolic_Enzyme_2_Theoretical_pI:
7.86

# Metabolic_Enzyme_2_GO_Classification:
Not Available

# Metabolic_Enzyme_2_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_2_Specific_Function:
May serve as a "flippase" as well as a glucosyltransferase that transfers glucose to ceramide

# Metabolic_Enzyme_2_Pathway:
map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_2_Reaction:
UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00535:Glycos_transf_2

# Metabolic_Enzyme_2_Signals:
1-29

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.4.1.80

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1325917

# Metabolic_Enzyme_2_SwissProt_ID:
CEGT_HUMAN (Q16739)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
UGCG

# Metabolic_Enzyme_2_Geneatlas_id:
UGCG

# Metabolic_Enzyme_2_hgnc_id:
HGNC:12524

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein

# Metabolic_Enzyme_2_Gene_Sequence:
>1185 bp
ATGGCGCTGCTGGACCTGGCCTTGGAGGGAATGGCCGTCTTCGGGTTCGTCCTCTTCTTG
GTGCTGTGGCTGATGCATTTCATGGCTATCATCTACACCCGATTACACCTCAACAAGAAG
GCAACTGACAAACAGCCTTATAGCAAGCTCCCAGGTGTCTCTCTTCTGAAACCACTGAAA
GGGGTAGATCCTAACTTAATCAACAACCTGGAAACATTCTTTGAATTGGATTATCCCAAA
TATGAAGTGCTCCTTTGTGTACAAGATCATGATGATCCAGCCATTGATGTATGTAAGAAG
CTTCTTGGAAAATATCCAAATGTTGATGCTAGATTGTTTATAGGTGGTAAAAAAGTTGGC
ATTAATCCTAAAATTAATAATTTAATGCCAGGATATGAAGTTGCAAAGTATGATCTTATA
TGGATTTGTGATAGTGGAATAAGAGTAATTCCAGATACGCTTACTGACATGGTGAATCAA
ATGACAGAAAAAGTAGGCTTGGTTCACGGGCTGCCTTACGTAGCAGACAGACAGGGCTTT
GCTGCCACCTTAGAGCAGGTATATTTTGGAACTTCACATCCAAGATACTATATCTCTGCC
AATGTAACTGGTTTCAAATGTGTGACAGGAATGTCTTGTTTAATGAGAAAAGATGTGTTG
GATCAAGCAGGAGGACTTATAGCTTTTGCTCAGTACATTGCCGAAGATTACTTTATGGCC
AAAGCGATAGCTGACCGAGGTTGGAGGTTTGCAATGTCCACTCAAGTTGCAATGCAAAAC
TCTGGCTCATATTCAATTTCTCAGTTTCAATCCAGAATGATCAGGTGGACCAAACTACGA
ATTAACATGCTTCCTGCTACAATAATTTGTGAGCCAATTTCAGAATGCTTTGTTGCCAGT
TTAATTATTGGATGGGCAGCCCACCATGTGTTCAGATGGGATATTATGGTATTTTTCATG
TGTCATTGCCTGGCATGGTTTATATTTGACTACATTCAACTCAGGGGTGTCCAGGGTGGC
ACACTGTGTTTTTCAAAACTTGATTATGCAGTCGCCTGGTTCATCCGCGAATCCATGACA
ATATACATTTTTTTGTCTGCATTATGGGACCCAACTATAAGCTGGAGAACTGGTCGCTAC
AGATTACGCTGTGGGGGTACAGCAGAGGAAATCCTAGATGTATAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
D50840

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_2_Locus:
9q31

# Metabolic_Enzyme_2_SNPs:
rs7850023; rs6477858; rs3780516; rs1813202; rs3739701; rs10759517; rs1413220; rs2166840; rs7042346; rs3780520; rs4317651; rs10759516; rs12686148; rs6477862; rs3824464; rs10817236; rs16916456; rs3780517; rs4979062; rs3780518; rs12685024; rs12554037; rs1333710; rs11792486; rs10817240; rs6477860; rs10817237; rs12348354; rs3780515; rs11790396; rs16916446; rs7467067; rs6477859; rs654745; rs17798946; rs12000654; rs4551439; rs1900694; rs12685593; rs11789159; rs7043273; rs10817239; rs12002419; rs7049002; rs10981151; rs10817238; rs12002392; rs41279075; rs10981150; rs34215541; rs12377408; rs10125124; rs1045976; rs1413219; rs1413218; rs7866863; rs12468; rs4979061; rs10817235; rs36015756; rs17853855; rs7871397; rs34014199; rs28689838; rs11398860; rs7867336; rs3780519; rs3217582; rs10981156; rs34569956; rs34205485; rs33941307; rs35175614; rs13283107; rs11452390; rs12236818; rs7858377; rs10981153; rs10643047; rs35895574; rs10577368; rs34436435; rs34920220; rs35083061; rs2594350; rs33940092; rs454073; rs35833099; rs34775531; rs41280159; rs7859033; rs10981148; rs34979381; rs34435886; rs551211; rs35147408; rs13284679; rs10981155; rs7045934; rs7855347; rs34434878; rs35438749; rs34580738; rs2780809; rs41279077; rs10981159; rs13283818; rs11452169; rs10660061; rs13301572; rs28567469; rs386621; rs34946497; rs35471909; rs2594347; rs35643596; rs2780810; rs13289900; rs10981149; rs10981152; rs2780808; rs12376152; rs36045165; rs2274942; rs34690862; rs12377525; rs10981157; rs35238379; rs35791118; rs12351165; rs7858784; rs34068047; rs2594346; rs10119090; rs41306480; rs41280157; rs10551745; rs12346859; rs7869363; rs10981154; rs10708488; rs11467927; rs34969837; rs12555612; rs10549559; rs11365963; rs13283634; rs9696370; rs10981146; rs35857900; rs10121390; rs10981147; rs28719626; rs10117724; rs10125129; rs1045989; rs10759519; rs10817241; rs10817242; rs10981144; rs10981162; rs10981164; rs10981165; rs10981168; rs12002077; rs12003668; rs12143; rs13913; rs16916486; rs28441469; rs6477856; rs7021349; rs7031902; rs7041171; rs7041597; rs7046626; rs7850734; rs7854170; rs7855135; rs7856540; rs7859449; rs7860208; rs7860334; rs7873908; rs9299201

# Metabolic_Enzyme_2_General_References:
8643456; 8901638

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5601

# Metabolic_Enzyme_3_Name:
Lactase-phlorizin hydrolase precursor

# Metabolic_Enzyme_3_Synonyms:
Lactase-glycosylceramidase[Includes: Lactase

# Metabolic_Enzyme_3_Gene_Name:
LCT

# Metabolic_Enzyme_3_Protein_Sequence:
>Lactasephlorizin hydrolase precursor
MELSWHVVFIALLSFSCWGSDWESDRNFISTAGPLTNDLLHNLSGLLGDQSSNFVAGDKD
MYVCHQPLPTFLPEYFSSLHASQITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKAL
KTARLQPMVILHHQTLPASTLRRTEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIK
ELPHQESRASQLQTLSDAHRKAYEIYHESYAFQGGKLSVVLRAEDIPELLLEPPISALAQ
DTVDFLSLDLSYECQNEASLRQKLSKLQTIEPKVKVFIFNLKLPDCPSTMKNPASLLFSL
FEAINKDQVLTIGFDINEFLSCSSSSKKSMSCSLTGSLALQPDQQQDHETTDSSPASAYQ
RVWEAFANQSRAERDAFLQDTFPEGFLWGASTGAFNVEGGWAEGGRGVSIWDPRRPLNTT
EGQATLEVASDSYHKVASDVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKL
IDRLQDAGIEPMATLFHWDLPQALQDHGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTF
HEPWVMSYAGYGTGQHPPGISDPGVASFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIV
LNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFVDGDYPATLRTQIQQMNRQCSHPV
AQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQHVNHVWPQT
SSSWIRVVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYIN
EVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTS
IIEKNGFLTKGAKRLLPPNTVNLPSKVRAFTFPSEVPSKAKVVWEKFSSQPKFERDLFYH
GTFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLD
ADLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFH
WDLPQALQDIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFP
PGVKDPGWAPYRIAHTVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDV
EAADRMLQFSLGWFAHPIFRNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRAT
ADVFCLNTYYSRIVQHKTPRLNPPSYEDDQEMAEEEDPSWPSTAMNRAAPWGTRRLLNWI
KEEYGDIPIYITENGVGLTNPNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWSLMD
NFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMPLAREDEFLYGRFPEG
FIWSAASAAYQIEGAWRADGKGLSIWDTFSHTPLRVENDAIGDVACDSYHKIAEDLVTLQ
NLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHWDLPQTL
QDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTAAPGVSNRP
GTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSNQEDVEAARRY
VQFMGGWFAHPIFKNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRINGTYDFFGF
NHYTTVLAYNLNYATAISSFDADRGVASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEY
NDPPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEW
ATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPDPATGPHACLHQPDAGPTI
SPVRQEEVQFLGLMLGTTEAQTALYVLFSLVLLGVCGLAFLSYKYCKRSKQGKTQRSQQE
LSPVSSF

# Metabolic_Enzyme_3_Number_of_Residues:
1927

# Metabolic_Enzyme_3_Molecular_Weight:
218604

# Metabolic_Enzyme_3_Theoretical_pI:
6.30

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  glucosidase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
LPH splits lactose in the small intestine

# Metabolic_Enzyme_3_Pathway:
map00052  Galactose metabolism

# Metabolic_Enzyme_3_Reaction:
lactose + H2O = D-galactose + D-glucose

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00232:Glyco_hydro_1

# Metabolic_Enzyme_3_Signals:
1-19

# Metabolic_Enzyme_3_Transmembrane_Regions:
1883-1901

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.2.1.108;EC 3.2.1.62

# Metabolic_Enzyme_3_GenBank_ID_Protein:
34400

# Metabolic_Enzyme_3_SwissProt_ID:
LPH_HUMAN (P09848)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
LCT

# Metabolic_Enzyme_3_Geneatlas_id:
LCT

# Metabolic_Enzyme_3_hgnc_id:
HGNC:6530

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cell membrane; apical cell membrane; single- pass type I membrane protein. Note=Brush border

# Metabolic_Enzyme_3_Gene_Sequence:
>5784 bp
ATGGAGCTGTCTTGGCATGTAGTCTTTATTGCCCTGCTAAGTTTTTCATGCTGGGGGTCA
GACTGGGAGTCTGATAGAAATTTCATTTCCACCGCTGGTCCTCTAACCAATGACTTGCTG
CACAACCTGAGTGGTCTCCTGGGAGACCAGAGTTCTAACTTTGTAGCAGGGGACAAAGAC
ATGTATGTTTGTCACCAGCCACTGCCCACTTTCCTGCCAGAATACTTCAGCAGTCTCCAT
GCCAGTCAGATCACCCATTATAAGGTATTTCTGTCATGGGCACAGCTCCTCCCAGCAGGA
AGCACCCAGAATCCAGACGAGAAAACAGTGCAGTGCTACCGGCGACTCCTCAAGGCCCTC
AAGACTGCACGGCTTCAGCCCATGGTCATCCTGCACCACCAGACCCTCCCTGCCAGCACC
CTCCGGAGAACCGAAGCCTTTGCTGACCTCTTCGCCGACTATGCCACATTCGCCTTCCAC
TCCTTCGGGGACCTAGTTGGGATCTGGTTCACCTTCAGTGACTTGGAGGAAGTGATCAAG
GAGCTTCCCCACCAGGAATCAAGAGCGTCACAACTCCAGACCCTCAGTGATGCCCACAGA
AAAGCCTATGAGATTTACCACGAAAGCTATGCTTTTCAGGGCGGAAAACTCTCTGTTGTC
CTGCGAGCTGAAGATATCCCGGAGCTCCTGCTAGAACCACCCATATCTGCGCTTGCCCAG
GACACGGTCGATTTCCTCTCTCTTGATTTGTCTTATGAATGCCAAAATGAGGCAAGTCTG
CGGCAGAAGCTGAGTAAATTGCAGACCATTGAGCCAAAAGTGAAAGTTTTCATCTTCAAC
CTAAAACTCCCAGACTGCCCCTCCACCATGAAGAACCCAGCCAGTCTGCTCTTCAGCCTT
TTTGAAGCCATAAATAAAGACCAAGTGCTCACCATTGGGTTTGATATTAATGAGTTTCTG
AGTTGTTCATCAAGTTCCAAGAAAAGCATGTCTTGTTCTCTGACTGGCAGCCTGGCCCTT
CAGCCTGACCAGCAGCAGGACCACGAGACCACGGACTCCTCTCCTGCCTCTGCCTATCAG
AGAGTCTGGGAAGCATTTGCCAATCAGTCCAGAGCGGAAAGGGATGCCTTCCTGCAGGAT
ACTTTCCCTGAAGGCTTCCTCTGGGGTGCCTCCACAGGAGCCTTTAACGTGGAAGGAGGC
TGGGCCGAGGGTGGGAGAGGGGTGAGCATCTGGGATCCACGCAGGCCCCTGAACACCACT
GAGGGCCAAGCGACGCTGGAGGTGGCCAGCGACAGTTACCACAAGGTAGCCTCTGACGTC
GCCCTGCTTTGCGGCCTCCGGGCTCAGGTGTACAAGTTCTCCATCTCCTGGTCCCGGATC
TTCCCCATGGGGCACGGGAGCAGCCCCAGCCTCCCAGGCGTTGCCTACTACAACAAGCTG
ATTGACAGGCTACAGGATGCGGGCATCGAGCCCATGGCCACGCTGTTCCACTGGGACCTG
CCTCAGGCCCTGCAGGATCATGGTGGATGGCAGAATGAGAGCGTGGTGGATGCCTTCCTG
GACTATGCGGCCTTCTGCTTCTCCACATTTGGGGACCGTGTGAAGCTGTGGGTGACCTTC
CATGAGCCGTGGGTGATGAGCTACGCAGGCTATGGCACCGGCCAGCACCCTCCCGGCATC
TCTGACCCAGGAGTGGCCTCTTTTAAGGTGGCTCACTTGGTCCTCAAGGCTCATGCCAGA
ACTTGGCACCACTACAACAGCCATCATCGCCCACAGCAGCAGGGGCACGTGGGCATTGTG
CTGAACTCAGACTGGGCAGAACCCCTGTCTCCAGAGAGGCCTGAGGACCTGAGAGCCTCT
GAGCGCTTCTTGCACTTCATGCTGGGCTGGTTTGCACACCCCGTCTTTGTGGATGGAGAC
TACCCAGCCACCCTGAGGACCCAGATCCAACAGATGAACAGACAGTGCTCCCATCCTGTG
GCTCAACTCCCCGAGTTCACAGAGGCAGAGAAGCAGCTCCTGAAAGGCTCTGCTGATTTT
CTGGGTCTGTCGCATTACACCTCCCGCCTCATCAGCAACGCCCCACAAAACACCTGCATC
CCTAGCTATGATACCATTGGAGGCTTCTCCCAACACGTGAACCATGTGTGGCCCCAGACC
TCATCCTCTTGGATTCGTGTGGTGCCCTGGGGGATAAGGAGGCTGTTGCAGTTTGTATCC
CTGGAATACACAAGAGGAAAAGTTCCAATATACCTTGCCGGGAATGGCATGCCCATAGGG
GAAAGTGAAAATCTCTTTGATGATTCCTTAAGAGTAGACTACTTCAATCAATATATCAAT
GAGGTGCTCAAGGCTATCAAGGAAGACTCTGTGGATGTTCGTTCCTACATTGCTCGTTCC
CTCATTGATGGCTTCGAAGGCCCTTCTGGTTACAGCCAGCGGTTTGGCCTGCACCACGTC
AACTTCAGCGACAGCAGCAAGTCAAGGACTCCCAGGAAATCTGCCTACTTTTTCACTAGC
ATCATAGAAAAGAACGGTTTCCTCACCAAGGGGGCAAAAAGACTGCTACCACCTAATACA
GTAAACCTCCCCTCCAAAGTCAGAGCCTTCACTTTTCCATCTGAGGTGCCCTCCAAGGCT
AAAGTCGTTTGGGAAAAGTTCTCCAGCCAACCCAAGTTCGAAAGAGATTTGTTCTACCAC
GGGACGTTTCGGGATGACTTTCTGTGGGGCGTGTCCTCTTCCGCTTATCAGATTGAAGGC
GCGTGGGATGCCGATGGCAAAGGCCCCAGCATCTGGGATAACTTTACCCACACACCAGGG
AGCAATGTGAAAGACAATGCCACTGGAGACATCGCCTGTGACAGCTATCACCAGCTGGAT
GCCGATCTGAATATGCTCCGAGCTTTGAAGGTGAAGGCCTACCGCTTCTCTATCTCCTGG
TCTCGGATTTTCCCAACTGGGAGAAACAGCTCTATCAACAGTCATGGGGTTGATTATTAC
AACAGGCTGATCAATGGCTTGGTGGCAAGCAACATCTTTCCCATGGTGACATTGTTCCAT
TGGGACCTGCCCCAGGCCCTCCAGGATATCGGAGGCTGGGAGAATCCTGCCTTGATTGAC
TTGTTTGACAGCTACGCAGACTTTTGTTTCCAGACCTTTGGTGATAGAGTCAAGTTTTGG
ATGACTTTTAATGAGCCCATGTACCTGGCATGGCTAGGTTATGGCTCAGGGGAATTTCCC
CCAGGGGTGAAGGACCCAGGCTGGGCACCATATAGGATAGCCCACACCGTCATCAAAGCC
CATGCCAGAGTCTATCACACGTACGATGAGAAATACAGGCAGGAGCAGAAGGGGGTCATC
TCGCTGAGCCTCAGTACACACTGGGCAGAGCCCAAGTCACCAGGGGTCCCCAGAGATGTG
GAAGCCGCTGACCGAATGCTGCAGTTCTCCCTGGGCTGGTTTGCTCACCCCATTTTTAGA
AACGGAGACTATCCTGACACCATGAAGTGGAAAGTGGGGAACAGGAGTGAACTGCAGCAC
TTAGCCACCTCCCGCCTGCCAAGCTTCACTGAGGAAGAGAAGAGGTTCATCAGGGCGACG
GCCGACGTCTTCTGCCTCAACACGTACTACTCCAGAATCGTGCAGCACAAAACACCCAGG
CTAAACCCACCCTCCTACGAAGACGACCAGGAGATGGCTGAGGAGGAGGACCCTTCGTGG
CCTTCCACGGCAATGAACAGAGCTGCGCCCTGGGGGACGCGAAGGCTGCTGAACTGGATC
AAGGAAGAGTATGGTGACATCCCCATTTACATCACCGAAAACGGAGTGGGGCTGACCAAT
CCGAACACGGAGGATACTGATAGGATATTTTACCACAAAACCTACATCAATGAGGCTTTG
AAAGCCTACAGGCTCGATGGTATAGACCTTCGAGGGTATGTCGCCTGGTCTCTGATGGAC
AACTTTGAGTGGCTAAATGGCTACACGGTCAAGTTTGGACTGTACCATGTTGATTTCAAC
AACACGAACAGGCCTCGCACAGCAAGAGCCTCCGCCAGGTACTACACAGAGGTCATTACC
AACAACGGCATGCCACTGGCCAGGGAGGATGAGTTTCTGTACGGACGGTTTCCTGAGGGC
TTCATCTGGAGTGCAGCTTCTGCTGCATATCAGATTGAAGGTGCGTGGAGAGCAGATGGC
AAAGGACTCAGCATTTGGGACACGTTTTCTCACACACCACTGAGGGTTGAGAACGATGCC
ATTGGAGACGTGGCCTGTGACAGTTATCACAAGATTGCTGAGGATCTGGTCACCCTGCAG
AACCTGGGTGTGTCCCACTACCGTTTTTCCATCTCCTGGTCTCGCATCCTCCCTGATGGA
ACCACCAGGTACATCAATGAAGCGGGCCTGAACTACTACGTGAGGCTCATCGATACACTG
CTGGCCGCCAGCATCCAGCCCCAGGTGACCATTTACCACTGGGACCTACCACAGACGCTC
CAAGATGTAGGAGGCTGGGAGAATGAGACCATCGTGCAGCGGTTTAAGGAGTATGCAGAT
GTGCTCTTCCAGAGGCTGGGAGACAAGGTGAAGTTTTGGATCACGTTGAATGAGCCCTTT
GTCATTGCTTACCAGGGCTATGGCTACGGAACAGCAGCTCCAGGAGTCTCCAATAGGCCT
GGCACTGCCCCCTACATTGTTGGCCACAATCTAATAAAGGCTCATGCTGAGGCCTGGCAT
CTGTACAACGATGTGTACCGCGCCAGTCAAGGTGGCGTGATTTCCATCACCATCAGCAGT
GACTGGGCTGAACCCAGAGATCCCTCTAACCAGGAGGATGTGGAGGCAGCCAGGAGATAT
GTTCAGTTCATGGGAGGCTGGTTTGCACATCCTATTTTCAAGAATGGAGATTACAATGAG
GTGATGAAGACGCGGATCCGTGACAGGAGCTTGGCTGCAGGCCTCAACAAGTCTCGGCTG
CCAGAATTTACAGAGAGTGAGAAGAGGAGGATCAACGGCACCTATGACTTTTTTGGGTTC
AATCACTACACCACTGTCCTCGCCTACAACCTCAACTATGCCACTGCCATCTCTTCTTTT
GATGCAGACAGAGGAGTTGCTTCCATCGCAGATCGCTCGTGGCCAGACTCTGGCTCCTTC
TGGCTGAAGATGACGCCTTTTGGCTTCAGGAGGATCCTGAACTGGTTAAAGGAGGAATAC
AATGACCCTCCAATTTATGTCACAGAGAATGGAGTGTCCCAGCGGGAAGAAACAGACCTC
AATGACACTGCAAGGATCTACTACCTTCGGACTTACATCAATGAGGCCCTCAAAGCTGTG
CAGGACAAGGTGGACCTTCGAGGATACACAGTTTGGAGTGCGATGGACAATTTTGAGTGG
GCCACAGGCTTTTCAGAGAGATTTGGTCTGCATTTTGTGAACTACAGTGACCCTTCTCTG
CCAAGGATCCCCAAAGCATCAGCGAAGTTCTACGCCTCTGTGGTCCGATGCAATGGCTTC
CCTGACCCCGCTACAGGGCCTCACGCTTGTCTCCACCAGCCAGATGCTGGACCCACCATC
AGCCCCGTGAGACAGGAGGAGGTGCAGTTCCTGGGGCTAATGCTCGGCACCACAGAAGCA
CAGACAGCTTTGTACGTTCTCTTTTCTCTTGTGCTTCTTGGAGTCTGTGGCTTGGCATTT
CTGTCATACAAGTACTGCAAGCGCTCTAAGCAAGGGAAAACACAACGAAGCCAACAGGAA
TTGAGCCCGGTGTCTTCATTCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X07994

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
2460343; 1902057

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
7434

# Metabolic_Enzyme_4_Name:
Caspase-3 precursor

# Metabolic_Enzyme_4_Synonyms:
CASP-3; Apopain; Cysteine protease CPP32; Yama protein; CPP-32; SREBP cleavage activity 1; SCA-1[Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]

# Metabolic_Enzyme_4_Gene_Name:
CASP3

# Metabolic_Enzyme_4_Protein_Sequence:
>Caspase3 precursor
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

# Metabolic_Enzyme_4_Number_of_Residues:
277

# Metabolic_Enzyme_4_Molecular_Weight:
31608

# Metabolic_Enzyme_4_Theoretical_pI:
6.51

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  cysteine-type endopeptidase activity
Function:  caspase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin

# Metabolic_Enzyme_4_Pathway:
Not Available

# Metabolic_Enzyme_4_Reaction:
Not Available

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00656:Peptidase_C14

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.4.22.56

# Metabolic_Enzyme_4_GenBank_ID_Protein:
561666

# Metabolic_Enzyme_4_SwissProt_ID:
CASP3_HUMAN (P42574)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CASP3

# Metabolic_Enzyme_4_Geneatlas_id:
CASP3

# Metabolic_Enzyme_4_hgnc_id:
HGNC:1504

# Metabolic_Enzyme_4_PDB_ID:
1CP3

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_4_Gene_Sequence:
>834 bp
ATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATC
ATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGAT
TATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGA
ATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAAC
TTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATG
CGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGC
CATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACA
AACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATT
CAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGAT
GACATGGCGTGTCATAAAATACCAGTGGATGCCGACTTCTTGTATGCATACTCCACAGCA
CCTGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGT
GCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAAC
CGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAA
CAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
U13737

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_4_Locus:
4q34

# Metabolic_Enzyme_4_SNPs:
rs35578277; rs1049210; rs35566035; rs1049253; rs2720378; rs3087455; rs6948; rs4647640; rs4647610; rs4647617; rs4647642; rs4647634; rs4647611; rs4647620; rs1049216; rs4647641; rs4647618; rs4647609; rs4647694; rs8549; rs4647698; rs4647614; rs4647621; rs4647622; rs4647616; rs4647633; rs4647643; rs4647630; rs34184817; rs4647647; rs35422505; rs4647624; rs4647626; rs4647696; rs4647606; rs4647631; rs4647646; rs4647607; rs4647625; rs34022730; rs35439719; rs2720377; rs4647632; rs4647628; rs2310103; rs34309992; rs4647629; rs4647644; rs4647636; rs2019978; rs2705891; rs1830254; rs2720376; rs2696056; rs4241793; rs4647667; rs4647688; rs4647663; rs1405942; rs4647652; rs1405938; rs4647662; rs2705901; rs1405944; rs4647671; rs4647665; rs2696057; rs4647693; rs4647672; rs2705897; rs4647669; rs4647673; rs4647692; rs4647674; rs4647666; rs4647686; rs4647683; rs4647690; rs4647657; rs4987118; rs4647679; rs4647670; rs4987119; rs4647658; rs4647684; rs4647675; rs4647650; rs34319440; rs4647685; rs2696048; rs4647651; rs4647676; rs4647687; rs4647655; rs13128316; rs13435139; rs4647704; rs4647700; rs12646257; rs4647701; rs4647623; rs4647635; rs10028033; rs12641602; rs13101834; rs11380373; rs4647695; rs34119644; rs2705892; rs34858791; rs35063555; rs4647699; rs4647639; rs34095700; rs4647619; rs13102911; rs4647645; rs4647612; rs13101835; rs4647637; rs4647638; rs2705893; rs4647649; rs2696060; rs10028034; rs4647697; rs4647613; rs35978407; rs4647608; rs4647615; rs28418774; rs4647648; rs1802667; rs34568867; rs7442206; rs4647682; rs4647656; rs4647681; rs4647668; rs4647677; rs4647678; rs4647691; rs35261594; rs4647689; rs4647653; rs35966919; rs34740772; rs4647659; rs41314884; rs9997231; rs3215361; rs4647661; rs4647654; rs10014306; rs10660141; rs4647664; rs4647660; rs4647680; rs10034836; rs35094553; rs9715122; rs4647705; rs34083547; rs9715863; rs4647702; rs4647703; rs11930666; rs12108497; rs12507711; rs13108061; rs13435890; rs1405937; rs2696058; rs2696059; rs2705881; rs2705882; rs2705900; rs2720388; rs2720389; rs34605630; rs4647600; rs4647602; rs4647603; rs4647605; rs4861629; rs4862396; rs4862399; rs7673753; rs7674164; rs7687648; rs9685847

# Metabolic_Enzyme_4_General_References:
7983002; 7774019; 7596430; 8673606; 9045680; 10821855; 8755496; 8696339

# Metabolic_Enzyme_4_References:
15033723; 16555301; 16710848

# Metabolic_Enzyme_5_ID:
6675

# Metabolic_Enzyme_5_Name:
Galactokinase

# Metabolic_Enzyme_5_Synonyms:
Galactose kinase

# Metabolic_Enzyme_5_Gene_Name:
GALK1

# Metabolic_Enzyme_5_Protein_Sequence:
>Galactokinase
MAALRQPQVAELLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELM
TVLVGSPRKDGLVSLLTTSEGADEPQRLQFPLPTAQRSLEPGTPRWANYVKGVIQYYPAA
PLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLCPDSGTIAARAQVCQQAEHSFAGM
PCGIMDQFISLMGQKGHALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLASSEYPVRR
RQCEEVARALGKESLREVQLEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDY
RAFGRLMVESHRSLRDDYEVSCPELDQLVEAALAVPGVYGSRMTGGGFGGCTVTLLEASA
APHAMRHIQEHYGGTATFYLSQAADGAKVLCL

# Metabolic_Enzyme_5_Number_of_Residues:
392

# Metabolic_Enzyme_5_Molecular_Weight:
42273

# Metabolic_Enzyme_5_Theoretical_pI:
6.42

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  galactokinase activity
 ||
>>>
Process:  phosphorus metabolism
Process:  phosphate metabolism
Process:  phosphorylation
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  carbohydrate phosphorylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  galactose metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_5_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Major enzyme for galactose metabolism

# Metabolic_Enzyme_5_Pathway:
map00052  Galactose metabolism

# Metabolic_Enzyme_5_Reaction:
ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF08544:GHMP_kinases_C;
PF00288:GHMP_kinases_N

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.7.1.6

# Metabolic_Enzyme_5_GenBank_ID_Protein:
1002507

# Metabolic_Enzyme_5_SwissProt_ID:
GALK1_HUMAN (P51570)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
GALK1

# Metabolic_Enzyme_5_Geneatlas_id:
GALK1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:4118

# Metabolic_Enzyme_5_PDB_ID:
1WUU

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Not Available

# Metabolic_Enzyme_5_Gene_Sequence:
>1179 bp
ATGGCTGCTTTGAGACAGCCCCAGGTCGCGGAGCTGCTGGCCGAGGCCCGGCGAGCCTTC
CGGGAGGAGTTCGGGGCCGAGCCCGAGCTGGCCGTGTCAGCGCCGGGCCGCGTCAACCTC
ATCGGGGAACACACGGACTACAACCAGGGCCTGGTGCTGCCTATGGCTCTGGAGCTCATG
ACGGTGCTGGTGGGCAGCCCCCGCAAGGATGGGCTGGTGTCTCTCCTCACCACCTCTGAG
GGTGCCGATGAGCCCCAGCGGCTGCAGTTTCCACTGCCCACAGCCCAGCGCTCGCTGGAG
CCTGGGACTCCTCGGTGGGCCAACTATGTCAAGGGAGTGATTCAGTACTACCCAGCTGCC
CCCCTCCCTGGCTTCAGTGCAGTGGTGGTCAGCTCAGTGCCCCTGGGGGGTGGCCTGTCC
AGCTCAGCATCCTTGGAAGTGGCCACGTACACCTTCCTCCAGCAGCTCTGTCCAGACTCG
GGCACAATAGCTGCCCGCGCCCAGGTGTGTCAGCAGGCCGAGCACAGCTTCGCAGGGATG
CCCTGTGGCATCATGGACCAGTTCATCTCACTTATGGGACAGAAAGGCCACGCGCTGCTC
ATTGACTGCAGGTCCTTGGAGACCAGCCTGGTGCCACTCTCGGACCCCAAGCTGGCCGTG
CTCATCACCAACTCTAATGTCCGCCACTCCCTGGCCTCCAGCGAGTACCCTGTGCGGCGG
CGCCAATGTGAAGAAGTGGCCCGGGCGCTGGGCAAGGAAAGCCTCCGGGAGGTACAACTG
GAAGAGCTAGAGGCTGCCAGGGACCTGGTGAGCAAAGAGGGCTTCCGGCGGGCCCGGCAC
GTGGTGGGGGAGATTCGGCGCACGGCCCAGGCAGCGGCCGCCCTGAGACGTGGCGACTAC
AGAGCCTTTGGCCGCCTCATGGTGGAGAGCCACCGCTCACTCAGAGACGACTATGAGGTG
AGCTGCCCAGAGCTGGACCAGCTGGTGGAGGCTGCGCTTGCTGTGCCTGGGGTTTATGGC
AGCCGCATGACGGGCGGTGGCTTCGGTGGCTGCACGGTGACACTGCTGGAGGCCTCCGCT
GCTCCCCACGCCATGCGGCACATCCAGGAGCACTACGGCGGGACTGCCACCTTCTACCTC
TCTCAAGCAGCCGATGGAGCCAAGGTGCTGTGCTTGTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U26401

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_5_Locus:
17q24

# Metabolic_Enzyme_5_SNPs:
rs7211385; rs820385; rs2444842; rs7209235; rs820384; rs820386; rs4788909; rs8073866; rs8078433; rs1979215; rs34947616; rs4633773; rs34122576; rs34653297; rs12601977; rs10624000; rs8072914; rs8074561; rs35053784; rs35008831; rs12602523; rs10670567; rs34651064; rs34797502; rs35352665; rs35989708; rs34208166; rs2603511; rs12940075; rs4392122; rs7212710; rs9912453; rs1008177; rs1008179; rs1051486; rs1051554; rs11465; rs11649838; rs13623; rs2603498; rs2603499; rs2603500; rs2603501; rs2603502; rs2603503; rs2603507; rs2603508; rs2603510; rs3191773; rs34536514; rs7223563; rs743554; rs8078247; rs820387; rs820388; rs820391; rs8669; rs871443; rs9367

# Metabolic_Enzyme_5_General_References:
7670469; 8908517; 7542884; 10521295; 11231902

# Metabolic_Enzyme_5_References:
15003454; 15464425; 16988899

# Metabolic_Enzyme_6_ID:
6192

# Metabolic_Enzyme_6_Name:
UDP-glucose 4-epimerase

# Metabolic_Enzyme_6_Synonyms:
Galactowaldenase; UDP-galactose 4-epimerase

# Metabolic_Enzyme_6_Gene_Name:
GALE

# Metabolic_Enzyme_6_Protein_Sequence:
>UDPglucose 4epimerase
MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV
EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK
AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA
VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD
YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR
EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA

# Metabolic_Enzyme_6_Number_of_Residues:
348

# Metabolic_Enzyme_6_Molecular_Weight:
38282

# Metabolic_Enzyme_6_Theoretical_pI:
6.71

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  isomerase activity
Function:  racemase and epimerase activity
Function:  racemase and epimerase activity, acting on carbohydrates and derivatives
Function:  UDP-glucose 4-epimerase activity
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
 ||
>>>
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  galactose metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide-sugar metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_6_Specific_Function:
Catalyzes two distinct but analogous reactions:the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine

# Metabolic_Enzyme_6_Pathway:
map00052  Galactose metabolism;
 map00520  Nucleotide sugars metabolism

# Metabolic_Enzyme_6_Reaction:
UDP-glucose = UDP-galactose

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF01370:Epimerase

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 5.1.3.2

# Metabolic_Enzyme_6_GenBank_ID_Protein:
1119217

# Metabolic_Enzyme_6_SwissProt_ID:
GALE_HUMAN (Q14376)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
GALE

# Metabolic_Enzyme_6_Geneatlas_id:
GALE

# Metabolic_Enzyme_6_hgnc_id:
HGNC:4116

# Metabolic_Enzyme_6_PDB_ID:
1EK6

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>1047 bp
ATGGCAGAGAAGGTGCTGGTAACAGGTGGGGCTGGCTACATTGGCAGCCACACGGTGCTG
GAGCTGCTGGAGGCTGGCTACTTGCCTGTGGTCATCGATAACTTCCATAATGCCTTCCGT
GGAGGGGGCTCCCTGCCTGAGAGCCTGCGGCGGGTCCAGGAGCTGACAGGCCGCTCTGTG
GAGTTTGAGGAGATGGACATTTTGGACCAGGGAGCCCTACAGCGTCTCTTCAAAAAGTAC
AGCTTTATGGCGGTCATCCACTTTGCGGGGCTCAAGGCCGTGGGCGAGTCGGTGCAGAAG
CCTCTGGATTATTACAGAGTTAACCTGACCGGGACCATCCAGCTTCTGGAGATCATGAAG
GCCCACGGGGTGAAGAACCTGGTGTTCAGCAGCTCAGCCACTGTGTACGGGAACCCCCAG
TACCTGCCCCTTGATGAGGCCCACCCCACGGGTGGTTGTACCAACCCTTACGGCAAGTCC
AAGTTCTTCATCGAGGAAATGATCCGGGACCTGTGCCAGGCAGACAAGACTTGGAACGTA
GTGCTGCTGCGCTATTTCAACCCCACAGGTGCCCATGCCTCTGGCTGCATTGGTGAGGAT
CCCCAGGGCATACCCAACAACCTCATGCCTTATGTCTCCCAGGTGGCGATCGGGCGACGG
GAGGCCCTGAATGTCTTTGGCAATGACTATGACACAGAGGATGGCACAGGTGTCCGGGAT
TACATCCATGTCGTGGATCTGGCCAAGGGCCACATTGCAGCCTTAAGGAAGCTGAAAGAA
CAGTGTGGCTGCCGGATCTACAACCTGGGCACGGGCACAGGCTATTCAGTGCTGCAGATG
GTCCAGGCTATGGAGAAGGCCTCTGGGAAGAAGATCCCGTACAAGGTGGTGGCACGGCGG
GAAGGTGATGTGGCAGCCTGTTACGCCAACCCCAGCCTGGCCCAAGAGGAGCTGGGGTGG
ACAGCAGCCTTAGGGCTGGACAGGATGTGTGAGGATCTCTGGCGCTGGCAGAAGCAGAAT
CCTTCAGGCTTTGGCACGCAAGCCTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
L41668

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_6_Locus:
1p36-p35

# Metabolic_Enzyme_6_SNPs:
rs3177813; rs760941; rs11805398; rs6692104; rs16828736; rs12031592; rs11546126; rs3177811; rs28940882; rs3179863; rs3204468; rs28940883; rs3180383; rs3180382; rs3179864; rs3180549; rs28940884; rs28940885; rs3179862; rs3180546; rs3180547; rs17403588; rs3180548; rs3177810; rs3177814; rs3180545; rs3177812; rs16861140; rs2473382; rs28479279; rs34385385; rs6666908; rs12141511; rs12038166; rs7551384; rs28719646; rs12041159; rs1018396; rs1042436; rs1046924; rs1049988; rs11584220; rs11714; rs12131539; rs15778; rs1803612; rs1803613; rs2076343; rs2232975; rs2232977; rs2232978; rs2232979; rs2232980; rs2232981; rs2232983; rs2256179; rs2473375; rs2473381; rs2502985; rs3203593; rs3209973; rs719400

# Metabolic_Enzyme_6_General_References:
8593531; 9538513; 10801319; 11279193; 9326324; 9973283

# Metabolic_Enzyme_6_References:
16611573; 17093269

# Metabolic_Enzyme_7_ID:
7965

# Metabolic_Enzyme_7_Name:
Aldose reductase

# Metabolic_Enzyme_7_Synonyms:
AR; Aldehyde reductase

# Metabolic_Enzyme_7_Gene_Name:
AKR1B1

# Metabolic_Enzyme_7_Protein_Sequence:
>Aldose reductase
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF

# Metabolic_Enzyme_7_Number_of_Residues:
316

# Metabolic_Enzyme_7_Molecular_Weight:
35854

# Metabolic_Enzyme_7_Theoretical_pI:
6.99

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies

# Metabolic_Enzyme_7_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism

# Metabolic_Enzyme_7_Reaction:
alditol + NAD(P)+ = aldose + NAD(P)H + H+

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.1.1.21

# Metabolic_Enzyme_7_GenBank_ID_Protein:
178487

# Metabolic_Enzyme_7_SwissProt_ID:
ALDR_HUMAN (P15121)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
AKR1B1

# Metabolic_Enzyme_7_Geneatlas_id:
AKR1B1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:381

# Metabolic_Enzyme_7_PDB_ID:
1T40

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_7_Gene_Sequence:
>951 bp
ATGGCAAGCCGTCTCCTGCTCAACAACGGCGCCAAGATGCCCATCCTGGGGTTGGGTACC
TGGAAGTCCCCTCCAGGGCAGGTGACTGAGGCCGTGAAGGTGGCCATTGACGTCGGGTAC
CGCCACATCGACTGTGCCCATGTGTACCAGAATGAGAATGAGGTGGGGGTGGCCATTCAG
GAGAAGCTCAGGGAGCAGGTGGTGAAGCGTGAGGAGCTCTTCATCGTCAGCAAGCTGTGG
TGCACGTACCATGAGAAGGGCCTGGTGAAAGGAGCCTGCCAGAAGACACTCAGCGACCTG
AAGCTGGACTACCTGGACCTCTACCTTATTCACTGGCCGACTGGCTTTAAGCCTGGGAAG
GAATTTTTCCCATTGGATGAGTCGGGCAATGTGGTTCCCAGTGACACCAACATTCTGGAC
ACGTGGGCGGCCATGGAAGAGCTGGTGGATGAAGGGCTGGTGAAAGCTATTGGCATCTCC
AACTTCAACCATCTCCAGGTGGAGATGATCTTAAACAAACCTGGCTTGAAGTATAAGCCT
GCAGTTAACCAGATTGAGTGCCACCCATATCTCACTCAGGAGAAGTTAATCCAGTACTGC
CAGTCCAAAGGCATCGTGGTGACCGCCTACAGCCCCCTCGGCTCTCCTGACAGGCCCTGG
GCCAAGCCCGAGGACCCTTCTCTCCTGGAGGATCCCAGGATCAAGGCGATCGCAGCCAAG
CACAATAAAACTACAGCCCAGGTCCTGATCCGGTTCCCCATGCAGAGGAACTTGGTGGTG
ATCCCCAAGTCTGTGACACCAGAACGCATTGCTGAGAACTTTAAGGTCTTTGACTTTGAA
CTGAGCAGCCAGGATATGACCACCTTACTCAGCTACAACAGGAACTGGAGGGTCTGTGCC
TTGTTGAGCTGTACCTCCCACAAGGATTACCCCTTCCATGAAGAGTTTTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
J04795

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_7_Locus:
7q35

# Metabolic_Enzyme_7_SNPs:
rs5054; rs5060; rs5059; rs2229543; rs3087630; rs5055; rs5053; rs1790999; rs1790998; rs1646640; rs4732027; rs2734653; rs3896278; rs2734650; rs10954455; rs1708432; rs10808275; rs17660462; rs2670227; rs11974100; rs2734657; rs2670232; rs1424426; rs2734649; rs2551472; rs2259458; rs17188118; rs12669537; rs2734655; rs7778371; rs1708434; rs11971263; rs2670230; rs10273906; rs17167854; rs2734665; rs969309; rs2701020; rs2734663; rs2734664; rs706207; rs759853; rs17167851; rs918825; rs918824; rs11975656; rs17856148; rs11544687; rs5057; rs4728325; rs5061; rs5062; rs5056; rs17849987; rs1803093; rs3210035; rs11544690; rs13306160; rs1803094; rs1803095; rs2852171; rs2854854; rs2551469; rs3749434; rs2734661; rs2670231; rs2551471; rs1791000; rs2670240; rs2734659; rs2852165; rs2551476; rs3216672; rs2854849; rs7801237; rs2269068; rs10588800; rs35880193; rs2734658; rs34559471; rs2691837; rs1732035; rs2852170; rs2854853; rs2670239; rs1646639; rs2854851; rs5058; rs2551470; rs2670233; rs13306159; rs2854848; rs2701019; rs2734660; rs1732037; rs2852164; rs11417418; rs35431624; rs2852163; rs2269069; rs35632302; rs2852173; rs2854850; rs2551473; rs35338055; rs2691840; rs2852172; rs2734652; rs2852167; rs2854852; rs6963238; rs1791006; rs34569487; rs2670229; rs2551475; rs2691838; rs13306161; rs3216673; rs2974975; rs2551474; rs34678793; rs2551467; rs33945153; rs2852169; rs2734656; rs2854846; rs2734651; rs2691839; rs2734662; rs2852166; rs2691841; rs2551468; rs2691835; rs2551477; rs2691836; rs13306162; rs1708427; rs2852168; rs2670226; rs1621922; rs2852174; rs2551465; rs2691845; rs2551466; rs918826; rs35706999; rs2852176; rs2691846; rs1708404; rs12532832; rs1732039; rs1646636; rs1646642; rs1646637; rs2852175; rs1646641; rs10228986; rs10236262; rs10236468; rs10241645; rs10244489; rs10252030; rs10263438; rs10275865; rs11973239; rs13225343; rs1708414; rs1708415; rs1708416; rs17167841; rs1722900; rs1722911; rs1732038; rs1791001; rs2347375; rs2670228; rs6977866; rs706206; rs7802421; rs782054

# Metabolic_Enzyme_7_General_References:
2498333; 2504709; 2510130; 2111143; 2112546; 1901857; 9195951; 8435445; 2492527; 8343525; 8281941; 8245005; 1621098; 1447221; 8234324; 9405046

# Metabolic_Enzyme_7_References:
15091323

# Metabolic_Enzyme_8_ID:
8825

# Metabolic_Enzyme_8_Name:
Lysosomal protective protein precursor

# Metabolic_Enzyme_8_Synonyms:
Cathepsin A; Carboxypeptidase C; Protective protein for beta-galactosidase[Contains: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain]

# Metabolic_Enzyme_8_Gene_Name:
CTSA

# Metabolic_Enzyme_8_Protein_Sequence:
>Lysosomal protective protein precursor
MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSK
HLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLI
ANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYA
GIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHC
CSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQD
LGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWD
MCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKME
VQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY


# Metabolic_Enzyme_8_Number_of_Residues:
480

# Metabolic_Enzyme_8_Molecular_Weight:
54467

# Metabolic_Enzyme_8_Theoretical_pI:
6.59

# Metabolic_Enzyme_8_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  exopeptidase activity
Function:  carboxypeptidase activity
Function:  serine carboxypeptidase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Amino acid transport and metabolism

# Metabolic_Enzyme_8_Specific_Function:
Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins

# Metabolic_Enzyme_8_Pathway:
Not Available

# Metabolic_Enzyme_8_Reaction:
Release of a C-terminal amino acid with broad specificity

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00450:Peptidase_S10

# Metabolic_Enzyme_8_Signals:
1-28

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.4.16.5

# Metabolic_Enzyme_8_GenBank_ID_Protein:
190283

# Metabolic_Enzyme_8_SwissProt_ID:
PPGB_HUMAN (P10619)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
CTSA

# Metabolic_Enzyme_8_Geneatlas_id:
CTSA

# Metabolic_Enzyme_8_hgnc_id:
HGNC:9251

# Metabolic_Enzyme_8_PDB_ID:
1IVY

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_8_Gene_Sequence:
>1443 bp
ATGATCCGAGCCGCGCCGCCGCCGCTGTTCCTGCTGCTGCTGCTGCTGCTGCTGCTAGTG
TCCTGGGCGTCCCGAGGCGAGGCAGCCCCCGACCAGGACGAGATCCAGCGCCTCCCCGGG
CTGGCCAAGCAGCCGTCTTTCCGCCAGTACTCCGGCTACCTCAAAAGCTCCGGCTCCAAG
CACCTCCACTACTGGTTTGTGGAGTCCCAGAAGGATCCCGAGAACAGCCCTGTGGTGCTT
TGGCTCAATGGGGGTCCCGGCTGCAGCTCACTAGATGGGCTCCTCACAGAGCATGGCCCC
TTCCTGGTCCAGCCAGATGGTGTCACCCTGGAGTACAACCCCTATTCTTGGAATCTGATT
GCCAATGTGTTATACCTGGAGTCCCCAGCTGGGGTGGGCTTCTCCTACTCCGATGACAAG
TTTTATGCAACTAATGACACTGAGGTCGCCCAGAGCAATTTTGAGGCCCTTCAAGATTTC
TTCCGCCTCTTTCCGGAGTACAAGAACAACAAACTTTTCCTGACCGGGGAGAGCTATGCT
GGCATCTACATCCCCACCCTGGCCGTGCTGGTCATGCAGGATCCCAGCATGAACCTTCAG
GGGCTGGCTGTGGGCAATGGACTCTCCTCCTATGAGCAGAATGACAACTCCCTGGTCTAC
TTTGCCTACTACCATGGCCTTCTGGGGAACAGGCTTTGGTCTTCTCTCCAGACCCACTGC
TGCTCTCAAAACAAGTGTAACTTCTATGACAACAAAGACCTGGAATGCGTGACCAATCTT
CAGGAAGTGGCCCGCATCGTGGGCAACTCTGGCCTCAACATCTACAATCTCTATGCCCCG
TGTGCTGGAGGGGTGCCCAGCCATTTTAGGTATGAGAAGGACACTGTTGTGGTCCAGGAT
TTGGGCAACATCTTCACTCGCCTGCCACTCAAGCGGATGTGGCATCAGGCACTGCTGCGC
TCAGGGGATAAAGTGCGCATGGACCCCCCCTGCACCAACACAACAGCTGCTTCCACCTAC
CTCAACAACCCGTACGTGCGGAAGGCCCTCAACATCCCGGAGCAGCTGCCACAATGGGAC
ATGTGCAACTTTCTGGTAAACTTACAGTACCGCCGTCTCTACCGAAGCATGAACTCCCAG
TATCTGAAGCTGCTTAGCTCACAGAAATACCAGATCCTATTATATAATGGAGATGTAGAC
ATGGCCTGCAATTTCATGGGGGATGAGTGGTTTGTGGATTCCCTCAACCAGAAGATGGAG
GTGCAGCGCCGGCCCTGGTTAGTGAAGTACGGGGACAGCGGGGAGCAGATTGCCGGCTTC
GTGAAGGAGTTCTCCCACATCGCCTTTCTCACGATCAAGGGCGCCGGCCACATGGTTCCC
ACCGACAAGCCCCTCGCTGCCTTCACCATGTTCTCCCGCTTCCTGAACAAGCAGCCATAC
TGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
M22960

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_8_Locus:
20q13.1

# Metabolic_Enzyme_8_SNPs:
rs25649; rs4608591; rs7270170; rs11569665; rs4810476; rs742034; rs11569663; rs6104390; rs6094225; rs11569662; rs11569664; rs11569667; rs2075961; rs2075962; rs2075963; rs11538053; rs11484230; rs6094226; rs5841612; rs33947058; rs34656072; rs3215446; rs6130962; rs34800818; rs34590242; rs6130963; rs11468785; rs6094227; rs11698406; rs6124756; rs34300421; rs11480920; rs396980; rs11569666; rs35404688; rs5841610; rs5841611; rs35814654; rs11482387; rs1056929; rs11086984; rs11086985; rs11569644; rs11569645; rs11569646; rs11569647; rs11569649; rs11569651; rs11569652; rs11569661; rs11569674; rs11569675; rs12481109; rs1736493; rs1804161; rs1804212; rs1804213; rs2077056; rs2664568; rs2664590; rs2868362; rs34017227; rs34942730; rs35165640; rs35342327; rs35972756; rs3746500; rs3817731; rs3827040; rs4812974; rs4942; rs553359; rs6017711; rs6032575; rs6032577; rs6032580; rs6065903; rs6065904; rs6073942; rs6073943; rs6073945; rs6073946; rs6073947; rs6073951; rs6073952; rs6094224; rs6104386; rs6104388; rs6104389; rs6104393; rs7268221; rs742035

# Metabolic_Enzyme_8_General_References:
3136930; 11780052; 1694176; 12665801; 1907282; 8591035; 1756715; 8514852

# Metabolic_Enzyme_8_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7014

# Macromolecular_Interacting_Partner_1_Name:
Ig alpha-1 chain C region

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
IGHA1

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Ig alpha1 chain C region
ASPTSPKVFPLSLCSTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDAS
GDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPVPSTPPTPSPSTPPTPSP
SCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLC
GCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEEL
ALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRV
AAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAEVDGTCY

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
353

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
37655

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.49

# Macromolecular_Interacting_Partner_1_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF07654:C1-set

# Macromolecular_Interacting_Partner_1_Signals:
1-3

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
184749

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
IGHA1_HUMAN (P01876)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
IGHA1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
IGHA1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:5478

# Macromolecular_Interacting_Partner_1_PDB_ID:
1IGA

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1061 bp
CATCCCCGACCAGCCCCAAGGTCTTCCCGCTGAGCCTCTGCAGCACCCAGCCAGATGGGA
ACGTGGTCATCGCCTGCCTGGTCCAGGGCTTCTTCCCCCAGGAGCCACTCAGTGTGACCT
GGAGCGAAAGCGGACAGGGCGTGACCGCCAGAAACTTCCCACCCAGCCAGGATGCCTCCG
GGGACCTGTACACCACGAGCAGCCAGCTGACCCTGCCGGCCACACAGTGCCTAGCCGGCA
AGTCCGTGACATGCCACGTGAAGCACTACACGAATCCCAGCCAGGATGTGACTGTGCCCT
GCCCAGTTCCCTCAACTCCACCTACCCCATCTCCCTCAACTCCACCTACCCCATCTCCCT
CATGCTGCCACCCCCGACTGTCACTGCACCGACCGGCCCTCGAGGACCTGCTCTTAGGTT
CAGAAGCGAACCTCACGTGCACACTGACCGGCCTGAGAGATGCCTCAGGTGTCACCTTCA
CCTGGACGCCCTCAAGTGGGAAGAGCGCTGTTCAAGGACCACCTGAGCGTGACCTCTGTG
GCTGCTACAGCGTGTCCAGTGTCCTGCCGGGCTGTGCCGAGCCATGGAACCATGGGAAGA
CCTTCACTTGCACTGCTGCCTACCCCGAGTCCAAGACCCCGCTAACCGCCACCCTCTCAA
AATCCGGAAACACATTCCGGCCCGAGGTCCACCTGCTGCCGCCGCCGTCGGAGGAGCTGG
CCCTGAACGAGCTGGTGACGCTGACGTGCCTGGCACGCGGCTTCAGCCCCAAGGACGTGC
TGGTTCGCTGGCTGCAGGGGTCACAGGAGCTGCCCCGCGAGAAGTACCTGACTTGGGCAT
CCCGGCAGGAGCCCAGCCAGGGCACCACCACCTTCGCTGTGACCAGCATACTGCGCGTGG
CAGCCGAGGACTGGAAGAAGGGGGACACCTTCTCCTGCATGGTGGGCCACGAGGCCCTGC
CGCTGGCCTTCACACAGAAGACCATCGACCGCTTGGCGGGTAAACCCACCCATGTCAATG
TGTCTGTTGTCATGGCGGAGGTGGACGGCACCTGCTACTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
J00220

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_1_Locus:
14q32.33

# Macromolecular_Interacting_Partner_1_SNPs:
rs7494172; rs4983647; rs1128852; rs1130510; rs12433324; rs1128849; rs17349690; rs4983644; rs4983645; rs1128862; rs1407; rs1128857; rs4983646; rs3210508; rs28833263; rs1129060; rs28843527; rs1129455; rs28643498; rs34671425; rs1129641; rs28581525; rs11546790; rs10140012; rs11546793; rs1129281; rs4072025; rs13000; rs1140166; rs1128904; rs1130897; rs1129079; rs34063614; rs1128856; rs11546791; rs1129554; rs1130877; rs1128917; rs1129781; rs4072026; rs11546792; rs1129604; rs10220590; rs3204510; rs11546795; rs1140501; rs34020292; rs1129591; rs1128899; rs1128855; rs3210526; rs1130746; rs12896746

# Macromolecular_Interacting_Partner_1_General_References:
6421489; 107164; 809331; 393607; 7506257; 2241915

# Macromolecular_Interacting_Partner_1_References:
15202611

# Macromolecular_Interacting_Partner_2_ID:
8325

# Macromolecular_Interacting_Partner_2_Name:
Asialoglycoprotein receptor 2

# Macromolecular_Interacting_Partner_2_Synonyms:
ASGP-R 2; ASGPR 2; Hepatic lectin H2

# Macromolecular_Interacting_Partner_2_Gene_Name:
ASGR2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Asialoglycoprotein receptor 2
MAKDFQDIQQLSSEENDHPFHQGEGPGTRRLNPRRGNPFLKGPPPAQPLAQRLCSMVCFS
LLALSFNILLLVVICVTGSQSEGHRGAQLQAELRSLKEAFSNFSSSTLTEVQAISTHGGS
VGDKITSLGAKLEKQQQDLKADHDALLFHLKHFPVDLRFVACQMELLHSNGSQRTCCPVN
WVEHQGSCYWFSHSGKAWAEAEKYCQLENAHLVVINSWEEQKFIVQHTNPFNTWIGLTDS
DGSWKWVDGTDYRHNYKNWAVTQPDNWHGHELGGSEDCVEVQPDGRWNDDFCLQVYRWVC
EKRRNATGEVA

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
311

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
35192

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.34

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00059:Lectin_C;
PF03954:Lectin_N

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
59-79

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
179081

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
ASGR2_HUMAN (P07307)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
ASGR2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
ASGR2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:743

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>936 bp
ATGGCCAAGGACTTTCAAGATATCCAGCAGCTGAGCTCGGAGGAAAATGACCATCCTTTC
CATCAAGGTGAGGGGCCAGGCACTCGCAGGCTGAATCCCAGGAGAGGAAATCCATTTTTG
AAAGGGCCACCTCCTGCCCAGCCCCTGGCACAGCGTCTCTGCTCCATGGTCTGCTTCAGT
CTGCTTGCCCTGAGCTTCAACATCCTGCTGCTGGTGGTCATCTGTGTGACTGGGTCCCAA
AGTGAGGGTCACAGAGGTGCACAGCTGCAAGCCGAGCTGCGGAGCCTGAAGGAAGCTTTC
AGCAACTTCTCCTCGAGCACCCTGACGGAGGTCCAGGCAATCAGCACCCACGGAGGCAGC
GTGGGTGACAAGATCACATCCCTAGGAGCCAAGCTGGAGAAACAGCAGCAGGACCTGAAA
GCAGATCACGATGCCCTGCTCTTCCATCTGAAGCACTTCCCCGTGGACCTGCGCTTCGTG
GCCTGCCAGATGGAGCTCCTCCACAGCAACGGCTCCCAAAGGACCTGCTGCCCCGTCAAC
TGGGTGGAGCACCAAGGCAGCTGCTACTGGTTCTCTCACTCCGGGAAGGCCTGGGCTGAG
GCGGAGAAGTACTGCCAGCTGGAGAACGCACACCTGGTGGTCATCAACTCCTGGGAGGAG
CAGAAATTCATTGTACAACACACGAACCCCTTCAATACCTGGATAGGTCTCACGGACAGT
GATGGCTCTTGGAAATGGGTGGATGGCACAGACTATAGGCACAACTACAAGAACTGGGCT
GTCACTCAGCCAGATAATTGGCACGGGCACGAGCTGGGTGGAAGTGAAGACTGTGTTGAA
GTCCAGCCGGATGGCCGCTGGAACGATGACTTCTGCCTGCAGGTGTACCGCTGGGTGTGT
GAGAAAAGGCGGAATGCCACCGGCGAGGTGGCCTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M11025

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_2_Locus:
17p

# Macromolecular_Interacting_Partner_2_SNPs:
rs2304978; rs11653054; rs2304979; rs920765; rs920764; rs2289645; rs920763; rs2289646; rs314239; rs2309665; rs417927; rs314233; rs7215728; rs2840110; rs552653; rs3785794; rs425694; rs4490049; rs314238; rs7220196; rs11652098; rs12952935; rs10459915; rs314236; rs3785795; rs7209215; rs314234; rs9284357; rs10459916; rs434325; rs367953; rs314237; rs4511588; rs3210784; rs554406; rs10438727; rs7216670; rs7214441; rs4796297; rs7212883; rs4324181; rs2120253; rs4290523; rs482087; rs2165886; rs11659039; rs3760354; rs3760352; rs7216610; rs2289644; rs7212330; rs3760353; rs35381090; rs34788257; rs11546183; rs35314842; rs4796386; rs34624974; rs34071920; rs167536; rs12952104; rs7207467; rs35834349; rs4572460; rs2455554; rs11653688; rs34205371; rs11867628; rs2304980; rs35639752; rs7221206; rs410635; rs483983; rs12940728; rs7213425; rs35505890; rs12949346; rs190087; rs35863743; rs35696008; rs7223764; rs35228905; rs28802291; rs3210783; rs35115466; rs314235; rs1222778; rs449128; rs429232; rs35249797; rs7211042; rs34821190; rs35310447; rs34874276; rs35161182; rs7211990; rs3214729; rs34424952; rs35359731; rs3834587; rs11656265; rs35796403; rs10521152; rs12951306; rs2455548; rs34067627; rs34530370; rs35682597; rs4455015; rs4796372; rs7216517; rs752345; rs8074337; rs8078782; rs8079569; rs924641; rs9907679

# Macromolecular_Interacting_Partner_2_General_References:
3863106; 1371982; 11543633

# Macromolecular_Interacting_Partner_2_References:
15648108; 15885467; 16004427; 16363699

# Macromolecular_Interacting_Partner_3_ID:
7795

# Macromolecular_Interacting_Partner_3_Name:
Galanin precursor [Contains: Galanin; Galanin message-associated peptide

# Macromolecular_Interacting_Partner_3_Synonyms:
GMAP]

# Macromolecular_Interacting_Partner_3_Gene_Name:
GAL

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Galanin precursor Contains: Galanin; Galanin messageassociated peptide
MARGSALLLASLLLAAALSASAGLWSPAKEKRGWTLNSAGYLLGPHAVGNHRSFSDKNGL
TSKRELRPEDDMKPGSFDRSIPENNIMRTIIEFLSFLHLKEAGALDRLLDLPAAASSEDI
ERS

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
123

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
13302

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
7.80

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF01296:Galanin;
PF06540:GMAP

# Macromolecular_Interacting_Partner_3_Signals:
1-19

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
488849

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
GALA_HUMAN (P22466)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
GAL

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
GAL

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:4114

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>136 bp
ATGGCCCGAGGCAGCGCCCTCCTGCTCGCCTCCCTCCTCCTCGCCGCGGCCCTTTCTGCC
TCTGCGGGGCTCTGGTCGCCGGCCAAGGAAAAACGAGGCTGGACCCTGAACAGCGCGGGC
TACCTGCTGGGCCCAC

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
L11144

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11q13.2

# Macromolecular_Interacting_Partner_3_SNPs:
rs34725707; rs1042577; rs7101947; rs3136537; rs3136540; rs1546309; rs694066; rs3136541; rs2513279; rs3136542; rs631097; rs3136538; rs3136539; rs1893679; rs2097042; rs948853; rs11228324; rs948852; rs4432027; rs948854; rs36058701; rs17852742; rs34569330; rs36101716; rs36070872; rs11228325; rs12289299; rs7939353; rs7924584; rs4528337; rs10791990; rs11228322; rs11602319; rs12796977; rs1943498; rs2187331; rs2510387; rs2513298; rs2513304; rs2513306; rs3136544; rs3136546; rs3136547; rs4930241; rs592973; rs6591349; rs7342173; rs7931715; rs7951412

# Macromolecular_Interacting_Partner_3_General_References:
7508413; 1370155; 1710578; 1722333

# Macromolecular_Interacting_Partner_3_References:
15670721; 15836737; 15896708; 16297867

# Macromolecular_Interacting_Partner_4_ID:
8081

# Macromolecular_Interacting_Partner_4_Name:
Leptin precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
Obesity factor; Obese protein

# Macromolecular_Interacting_Partner_4_Gene_Name:
LEP

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Leptin precursor
MHWGTLCGFLWLWPYLFYVQAVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGL
DFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLP
WASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
167

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
18641

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.34

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF02024:Leptin

# Macromolecular_Interacting_Partner_4_Signals:
1-21

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
623332

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
LEP_HUMAN (P41159)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
LEP

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
LEP

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:6553

# Macromolecular_Interacting_Partner_4_PDB_ID:
1AX8

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>504 bp
ATGCATTGGGGAACCCTGTGCGGATTCTTGTGGCTTTGGCCCTATCTTTTCTATGTCCAA
GCTGTGCCCATCCAAAAAGTCCAAGATGACACCAAAACCCTCATCAAGACAATTGTCACC
AGGATCAATGACATTTCACACACGCAGTCAGTCTCCTCCAAACAGAAAGTCACCGGTTTG
GACTTCATTCCTGGGCTCCACCCCATCCTGACCTTATCCAAGATGGACCAGACACTGGCA
GTCTACCAACAGATCCTCACCAGTATGCCTTCCAGAAACGTGATCCAAATATCCAACGAC
CTGGAGAACCTCCGGGATCTTCTTCACGTGCTGGCCTTCTCTAAGAGCTGCCACTTGCCC
TGGGCCAGTGGCCTGGAGACCTTGGACAGCCTGGGGGGTGTCCTGGAAGCTTCAGGCTAC
TCCACAGAGGTGGTGGCCCTGAGCAGGCTGCAGGGGTCTCTGCAGGACATGCTGTGGCAG
CTGGACCTCAGCCCTGGGTGCTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
U18915

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_4_Locus:
7q31.3

# Macromolecular_Interacting_Partner_4_SNPs:
rs17151919; rs13306517; rs28954113; rs11763517; rs4731426; rs10954173; rs11761556; rs4731427; rs2167270; rs7791621; rs10257175; rs12706832; rs11760956; rs7795794; rs28954116; rs11978419; rs10244329; rs17151922; rs2278814; rs28959471; rs10954174; rs4236625; rs7796202; rs28954117; rs28959470; rs28954095; rs28954101; rs28954086; rs28954099; rs28959468; rs3750034; rs28954093; rs2278815; rs2122627; rs28954379; rs28959474; rs28954082; rs41457646; rs28954114; rs28954096; rs28959476; rs28954084; rs28954102; rs28954100; rs2060713; rs28954090; rs28954098; rs28954105; rs28954118; rs11980266; rs28954091; rs12706831; rs28959475; rs28954094; rs28954083; rs28756049; rs11973652; rs3793162; rs17151913; rs17151914; rs6956510; rs2071045; rs3828942; rs7788818; rs10264361; rs28954109; rs28954110; rs28954108; rs28954111; rs791616; rs28954376; rs28954081; rs6976701; rs10262600; rs28954369; rs28954080; rs28954371; rs34104384; rs4728096; rs791620; rs28954372; rs28954373; rs28954375; rs35048003; rs28959478; rs10258300; rs12536535; rs28954378; rs13228377; rs1800564; rs1800583; rs28954097; rs11380467; rs35394014; rs28959469; rs10676401; rs28954106; rs1031340; rs28954115; rs1349398; rs34219283; rs28959472; rs28954088; rs10243710; rs6966536; rs28954104; rs10620014; rs34457895; rs13306516; rs33910507; rs28954107; rs41526944; rs41434248; rs28954087; rs34728887; rs28954103; rs28959473; rs41528456; rs17617757; rs28954089; rs28954092; rs34052732; rs10277407; rs28954112; rs41474844; rs13306518; rs35447711; rs34046133; rs36212573; rs28959477; rs36219262; rs791618; rs28954370; rs791619; rs34669250; rs10598051; rs28954377; rs36219261; rs28391558; rs791617; rs28954374; rs36219260; rs10249476; rs10264838; rs10276311; rs10487506; rs10954175; rs10954176; rs11770725; rs12535708; rs12535747; rs12537573; rs13245201; rs1349419; rs1376268; rs16871960; rs17151895; rs2060715; rs2167271; rs35854831; rs4731423; rs4731424; rs4731428; rs4731429; rs4731430; rs6949498; rs712722; rs7778154; rs7782257; rs7798338; rs7799039; rs7801674; rs7802530; rs791604; rs791606; rs791607; rs791608; rs791610; rs791611; rs791612; rs791613; rs791614; rs791615

# Macromolecular_Interacting_Partner_4_General_References:
7984236; 7789654; 8626726; 7499240; 8621021; 10428856; 9166907; 9144295; 9500540

# Macromolecular_Interacting_Partner_4_References:
15068959; 15081399

# Macromolecular_Interacting_Partner_5_ID:
8452

# Macromolecular_Interacting_Partner_5_Name:
Lymphotoxin-beta

# Macromolecular_Interacting_Partner_5_Synonyms:
LT-beta; Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3

# Macromolecular_Interacting_Partner_5_Gene_Name:
LTB

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Lymphotoxinbeta
MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD
PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS
DAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLE
GAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGA
VMVG

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
244

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
25390

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
5.02

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_5_Signals:
1-35

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
292279

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
TNFC_HUMAN (Q06643)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
LTB

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
LTB

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:6711

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>735 bp
ATGGGGGCACTGGGGCTGGAGGGCAGGGGTGGGAGGCTCCAGGGGAGGGGTTCCCTCCTG
CTAGCTGTGGCAGGAGCCACTTCTCTGGTGACCTTGTTGCTGGCGGTGCCTATCACTGTC
CTGGCTGTGCTGGCCTTAGTGCCCCAGGATCAGGGAGGACTGGTAACGGAGACGGCCGAC
CCCGGGGCACAGGCCCAGCAAGGACTGGGGTTTCAGAAGCTGCCAGAGGAGGAGCCAGAA
ACAGATCTCAGCCCCGGGCTCCCAGCTGCCCACCTCATAGGCGCTCCGCTGAAGGGGCAG
GGGCTAGGCTGGGAGACGACGAAGGAACAGGCGTTTCTGACGAGCGGGACGCAGTTCTCG
GACGCCGAGGGGCTGGCGCTCCCGCAGGACGGCCTCTATTACCTCTACTGTCTCGTCGGC
TACCGGGGCCGGGCGCCCCCTGGCGGCGGGGACCCCCAGGGCCGCTCGGTCACGCTGCGC
AGCTCTCTGTACCGGGCGGGGGGCGCCTACGGGCCGGGCACTCCCGAGCTGCTGCTCGAG
GGCGCCGAGACGGTGACTCCAGTGCTGGACCCGGCCAGGAGACAAGGGTACGGGCCTCTC
TGGTACACGAGCGTGGGGTTCGGCGGCCTGGTGCAGCTCCGGAGGGGCGAGAGGGTGTAC
GTCAACATCAGTCACCCCGATATGGTGGACTTCGCGAGAGGGAAGACCTTCTTTGGGGCC
GTGATGGTGGGGTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
L11016

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_5_Locus:
6p21.3

# Macromolecular_Interacting_Partner_5_SNPs:
Not Available

# Macromolecular_Interacting_Partner_5_General_References:
7916655; 9299492; 10202016

# Macromolecular_Interacting_Partner_5_References:
15818560; 16299325; 16620826

# Macromolecular_Interacting_Partner_6_ID:
8383

# Macromolecular_Interacting_Partner_6_Name:
C-type lectin domain family 4 member F

# Macromolecular_Interacting_Partner_6_Synonyms:
C-type lectin superfamily member 13; C-type lectin 13

# Macromolecular_Interacting_Partner_6_Gene_Name:
CLEC4F

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Ctype lectin domain family 4 member 
FMDGEAVRFCTDNQCVSPHPQEVDSVAMAPAAPKIPRLVQATPAFMAVTLVFSLVTLFVV
VQQQTRPVPKPVQAVILGDNITGHLPFEPNNHHHFGREAEMRELIQTFKGHMENSSAWVV
EIQMLKCRVDNVNSQLQVLGDHLGNTNADIQMVKGVLKDATTLSLQTQMLRSSLEGTNAE
IQRLKEDLEKADALTFQTLNFLKSSLENTSIELHVLSRGLENANSEIQMLNASLETANTQ
AQLANSSLKNANAEIYVLRGHLDSVNDLRTQNQVLRNSLEGANAEIQGLKENLQNTNALN
SQTQAFIKSSFDNTSAEIQFLRGHLERAGDEIHVLKRDLKMVTAQTQKANGRLDQTDTQI
QVFKSEMENVNTLNAQIQVLNGHMKNASREIQTLKQGMKNASALTSQTQMLDSNLQKASA
EIQRLRGDLENTKALTMEIQQEQSRLKTLHVVITSQEQLQRTQSQLLQMVLQGWKFNGGS
LYYFSSVKKSWHEAEQFCVSQGAHLASVASKEEQAFLVEFTSKVYYWIGLTDRGTEGSWR


# Macromolecular_Interacting_Partner_6_Number_of_Residues:
539

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
60209

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
6.46

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Cell motility 

# Macromolecular_Interacting_Partner_6_Specific_Function:
Receptor with an affinity for galactose and fucose. Could be involved in endocytosis

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00059:Lectin_C

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
40-60

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
21755922

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
CLC4F_HUMAN (Q8N1N0)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
CLEC4F

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
CLEC4F

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:25357

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1620 bp
ATGGACGGTGAGGCAGTCCGCTTCTGCACAGATAACCAGTGTGTCTCCCCGCACCCCCAA
GAGGTGGACTCTGTGGCAATGGCTCCTGCAGCCCCCAAGATACCGAGGCTCGTTCAGGCT
ACCCCGGCATTTATGGCTGTGACCTTGGTCTTCTCTCTTGTGACTCTCTTTGTAGTGGTT
CAACAGCAGACAAGACCTGTTCCGAAGCCTGTGCAAGCCGTAATTCTGGGAGACAACATT
ACTGGGCATTTACCTTTTGAACCCAACAATCATCACCACTTTGGCAGGGAGGCAGAAATG
CGAGAGCTTATCCAGACATTTAAAGGCCACATGGAGAATTCCAGTGCCTGGGTAGTAGAA
ATCCAGATGTTGAAGTGCAGAGTGGACAATGTCAATTCGCAGCTCCAGGTGCTCGGTGAT
CATCTGGGAAACACCAATGCTGACATCCAGATGGTAAAAGGAGTTCTAAAGGATGCCACT
ACATTGAGTTTGCAGACACAGATGTTAAGGAGTTCCCTGGAGGGAACCAATGCTGAGATC
CAGAGGCTCAAGGAAGACCTTGAAAAGGCAGATGCTTTAACTTTCCAGACGCTGAATTTC
TTAAAAAGCAGTTTAGAAAACACCAGCATTGAGCTCCACGTGCTAAGCAGAGGCTTAGAA
AATGCAAACTCTGAAATTCAGATGTTGAATGCCAGTTTGGAAACGGCAAATACCCAGGCT
CAGTTAGCCAATAGCAGTTTAAAGAACGCTAATGCTGAGATCTATGTTTTGAGAGGCCAT
CTAGATAGTGTCAATGACTTGAGGACCCAGAACCAGGTTTTAAGAAATAGTTTGGAAGGA
GCCAATGCTGAGATCCAGGGACTAAAGGAAAATTTGCAGAACACAAATGCTTTAAACTCC
CAGACCCAGGCCTTTATAAAAAGCAGTTTTGACAACACTAGTGCTGAGATCCAGTTCTTA
AGAGGTCATTTGGAAAGAGCTGGTGATGAAATTCACGTGTTAAAAAGGGATTTGAAAATG
GTCACAGCCCAGACCCAAAAAGCAAATGGCCGTCTGGACCAGACAGATACTCAGATTCAG
GTATTCAAGTCAGAGATGGAAAATGTGAATACCTTAAATGCCCAGATTCAGGTCTTAAAT
GGTCATATGAAAAATGCCAGCAGAGAGATACAGACCCTAAAACAAGGAATGAAGAATGCT
TCAGCCTTAACTTCCCAGACCCAGATGTTAGACAGCAATCTGCAGAAGGCCAGTGCCGAG
ATCCAGAGGTTAAGAGGGGATCTAGAGAACACCAAAGCTCTAACCATGGAAATCCAGCAG
GAGCAGAGTCGCCTGAAGACCCTCCATGTGGTCATTACTTCACAGGAACAGCTACAAAGA
ACCCAAAGTCAGCTTCTCCAGATGGTCCTGCAAGGCTGGAAGTTCAATGGTGGAAGCTTA
TATTATTTTTCTAGTGTCAAGAAGTCTTGGCATGAGGCTGAGCAGTTCTGCGTGTCCCAG
GGAGCCCATCTGGCATCTGTGGCCTCCAAGGAGGAGCAGGCATTTCTGGTAGAGTTCACA
AGTAAAGTGTACTACTGGATCGGTCTCACTGACAGGGGCACAGAGGGCTCCTGGCGCTGA


# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
AK096429

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_6_Locus:
2p13.3

# Macromolecular_Interacting_Partner_6_SNPs:
rs722896; rs2075221; rs2287101; rs17006361; rs2287100; rs2075222; rs10181677; rs17656087; rs17656058; rs10181668; rs10184940; rs17006359; rs6710161; rs10175452; rs7419407; rs1548888; rs1548889; rs6749945; rs2902581; rs10198090; rs6749933; rs1548890; rs34875126; rs35001900; rs35381972; rs34318515; rs35637981; rs10178512; rs13035611; rs34855823; rs36077964; rs35483718; rs1861449; rs3217143; rs34067081; rs12611961; rs11546485; rs10199047; rs11677263; rs28412641; rs10208515; rs35788870; rs28785541; rs5832035; rs33969123; rs10185297; rs5832034; rs34800537; rs35936910; rs13030555; rs35932660; rs11894422; rs2080389; rs34256142; rs1005428; rs1005429; rs10168115; rs10192228; rs10193839; rs10198019; rs11126297; rs11126300; rs11684437; rs11684466; rs12991771; rs13015305; rs13015834; rs13389680; rs13389683; rs13412064; rs1544649; rs1544650; rs1544651; rs1544652; rs1544653; rs1544654; rs1548891; rs1548893; rs17006339; rs17656571; rs2075223; rs2075224; rs2110978; rs2863803; rs2863804; rs2863807; rs35856355; rs35893929; rs4852228; rs6546640; rs6712273; rs6715047; rs6725094; rs7560275; rs7575872; rs7575952; rs7586340; rs7587185; rs7587512

# Macromolecular_Interacting_Partner_6_General_References:
Not Available

# Macromolecular_Interacting_Partner_6_References:
15049685; 15134836; 16670103

# Macromolecular_Interacting_Partner_7_ID:
8500

# Macromolecular_Interacting_Partner_7_Name:
Solute carrier family 2, facilitated glucose transporter member 10

# Macromolecular_Interacting_Partner_7_Synonyms:
Glucose transporter type 10

# Macromolecular_Interacting_Partner_7_Gene_Name:
SLC2A10

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Solute carrier family 2, facilitated glucose transporter member 10
MGHSPPVLPLCASVSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALL
ASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACC
IYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTPWGWRHMFGWATAPAVLQSL
SLLFLPAGTDETATHKDLIPLQGGEAPKLGPGRPRYSFLDLFRARDNMRGRTTVGLGLVL
FQQLTGQPNVLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALL
LAGCALMALSVSGIGLVSFAVPMDSGPSCLAVPNATGQTGLPGDSGLLQDSSLPPIPRTN
EDQREPILSTAKKTKPHPRSGDPSAPPRLALSSALPGPPLPARGHALLRWTALLCLMVFV
SAFSFGFGPVTWLVLSEIYPVEIRGRAFAFCNSFNWAANLFISLSFLDLIGTIGLSWTFL
LYGLTAVLGLGFIYLFVPETKGQSLAEIDQQFQKRRFTLSFGHRQNSTGIPYSRIEISAA
S

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
541

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
56912

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
8.68

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
 Function:  carrier activity
Function:  electrochemical potential-driven transporter activity
Function:  porter activity
Function:  sugar porter activity
Function:  transporter activity
 ||
>>>
 Process:  carbohydrate transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_7_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_7_Specific_Function:
Facilitative glucose transporter

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00083:Sugar_tr

# Macromolecular_Interacting_Partner_7_Signals:
1-422

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
16-36
49-69
78-98
107-127
135-155
167-187
234-254
270-290
299-319
415-435
446-466
477-497

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
13445575

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
GTR10_HUMAN (O95528)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
SLC2A10

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
SLC2A10

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:13444

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Intracytoplasmic membrane; multi-pass membrane protein. Cytoplasm; perinuclear region

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1626 bp
ATGGGCCACTCCCCACCTGTCCTGCCTTTGTGTGCCTCTGTGTCTTTGCTGGGTGGCCTG
ACCTTTGGTTATGAACTGGCAGTCATATCAGGTGCCCTGCTGCCACTGCAGCTTGACTTT
GGGCTAAGCTGCTTGGAGCAGGAGTTCCTGGTGGGCAGCCTGCTCCTGGGGGCTCTCCTC
GCCTCCCTGGTTGGTGGCTTCCTCATTGACTGCTATGGCAGGAAGCAAGCCATCCTCGGG
AGCAACTTGGTGCTGCTGGCAGGCAGCCTGACCCTGGGCCTGGCTGGTTCCCTGGCCTGG
CTGGTCCTGGGCCGCGCTGTGGTTGGCTTCGCCATTTCCCTCTCCTCCATGGCTTGCTGT
ATCTACGTGTCAGAGCTGGTGGGGCCACGGCAGCGGGGAGTGCTGGTGTCCCTCTATGAG
GCAGGCATCACCGTGGGCATCCTGCTCTCCTATGCCCTCAACTATGCACTGGCTGGTACC
CCCTGGGGATGGAGGCACATGTTCGGCTGGGCCACTGCACCTGCTGTCCTGCAATCCCTC
AGCCTCCTCTTCCTCCCTGCTGGTACAGATGAGACTGCAACACACAAGGACCTCATCCCA
CTCCAGGGAGGTGAGGCCCCCAAGCTGGGCCCGGGGAGGCCACGGTACTCCTTTCTGGAC
CTCTTCAGGGCACGCGATAACATGCGAGGCCGGACCACAGTGGGCCTGGGGCTGGTGCTC
TTCCAGCAACTAACAGGGCAGCCCAACGTGCTGTGCTATGCCTCCACCATCTTCAGCTCC
GTTGGTTTCCATGGGGGATCCTCAGCCGTGCTGGCCTCTGTGGGGCTTGGCGCAGTGAAG
GTGGCAGCTACCCTGACCGCCATGGGGCTGGTGGACCGTGCAGGCCGCAGGGCTCTGTTG
CTAGCTGGCTGTGCCCTCATGGCCCTGTCCGTCAGTGGCATAGGCCTCGTCAGCTTTGCC
GTGCCCATGGACTCAGGCCCAAGCTGTCTGGCTGTGCCCAATGCCACCGGGCAGACAGGC
CTCCCTGGAGACTCTGGCCTGCTGCAGGACTCCTCTCTACCTCCCATTCCAAGGACCAAT
GAGGACCAAAGGGAGCCAATCTTGTCCACTGCTAAGAAAACCAAGCCCCATCCCAGATCT
GGAGACCCCTCAGCCCCTCCTCGGCTGGCCCTGAGCTCTGCCCTCCCTGGGCCCCCTCTG
CCCGCTCGGGGGCATGCACTGCTGCGCTGGACCGCACTGCTGTGCCTGATGGTCTTTGTC
AGTGCCTTCTCCTTTGGGTTTGGGCCAGTGACCTGGCTTGTCCTCAGCGAGATCTACCCT
GTGGAGATACGAGGAAGAGCCTTCGCCTTCTGCAACAGCTTCAACTGGGCGGCCAACCTC
TTCATCAGCCTCTCCTTCCTCGATCTCATTGGCACCATCGGCTTGTCCTGGACCTTCCTG
CTCTACGGACTGACCGCTGTCCTCGGCCTGGGCTTCATCTATTTATTTGTTCCTGAAACA
AAAGGCCAGTCGTTGGCAGAGATAGACCAGCAGTTCCAGAAGAGACGGTTCACCCTGAGC
TTTGGCCACAGGCAGAACTCCACTGGCATCCCGTACAGCCGCATCGAGATCTCTGCGGCC
TCCTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
AF321240

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_7_Locus:
20q13.1

# Macromolecular_Interacting_Partner_7_SNPs:
rs6018008; rs7348121; rs2235491; rs6094438; rs34295241; rs707507; rs1059217; rs1136540; rs1136544; rs6012025; rs6018010; rs2425911; rs3091904; rs998422; rs2425901; rs6017999; rs3091788; rs2425902; rs3092053; rs3092439; rs2425910; rs2425903; rs6512388; rs6124855; rs4239646; rs3091514; rs2425907; rs4810546; rs2143044; rs4809600; rs2076293; rs6512389; rs6017998; rs2425909; rs3092412; rs998423; rs760872; rs2425899; rs3091421; rs3091822; rs6012019; rs11086177; rs1122067; rs2425904; rs2425896; rs7272875; rs6018005; rs8119275; rs3092211; rs8114951; rs6018004; rs2425900; rs2425898; rs6018006; rs7267790; rs3091961; rs6012022; rs6017995; rs3092706; rs3091934; rs4810545; rs17861024; rs2425895; rs35151194; rs34605643; rs41283344; rs35833600; rs34990188; rs6094447; rs41283042; rs6094446; rs34912587; rs6066056; rs34965637; rs6094450; rs6094448; rs3091691; rs36103903; rs11541582; rs9046; rs6066055; rs6066057; rs6018009; rs6094449; rs35691491; rs35087171; rs11086179; rs11341417; rs8122241; rs6066049; rs3091474; rs2425897; rs6094443; rs6066050; rs35623541; rs6018007; rs7266228; rs6012020; rs3091944; rs6063017; rs3091554; rs35700088; rs6094441; rs6066052; rs6094445; rs7272321; rs6012024; rs10624698; rs6018002; rs6094437; rs11483528; rs2425906; rs35295123; rs6090544; rs6012021; rs3092014; rs34105557; rs7266179; rs6124853; rs36117506; rs6066047; rs6063016; rs35102875; rs6094442; rs6063018; rs35302720; rs6090545; rs11474416; rs8123413; rs11477202; rs6066051; rs6094440; rs6094439; rs6090543; rs34455275; rs12481018; rs13043534; rs6018001; rs34020691; rs11472342; rs6066053; rs6066054; rs6094436; rs11479560; rs11472815; rs35220320; rs8116529; rs34955100; rs6066046; rs6094444; rs4428069; rs34503605; rs6012023; rs35119522; rs10650846; rs6094435; rs2425894; rs6017994; rs36220016; rs11470362; rs11266962; rs1003513; rs1003514; rs11699610; rs11699667; rs12479748; rs12479945; rs16991799; rs2179357; rs2425893; rs2903953; rs3091537; rs3092621; rs4618107; rs4809599; rs4810542; rs4810543; rs6012017; rs6012026; rs6012028; rs6012029; rs6012030; rs6017989; rs6018015; rs6018016; rs6018018; rs6018019; rs6018020; rs6018021; rs6063019; rs6066058; rs6066059; rs6090546; rs6094451; rs6094455; rs7270203; rs7343687; rs737543; rs742321; rs8120698; rs8125934

# Macromolecular_Interacting_Partner_7_General_References:
11247674; 11780052

# Macromolecular_Interacting_Partner_7_References:
Not Available

# Macromolecular_Interacting_Partner_8_ID:
8661

# Macromolecular_Interacting_Partner_8_Name:
Solute carrier family 5

# Macromolecular_Interacting_Partner_8_Synonyms:
Sodium/glucose cotransporter, member 9

# Macromolecular_Interacting_Partner_8_Gene_Name:
SLC5A9

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Solute carrier family 5
MGPGASGDGVRTETAPHIALDSRVGLHAYDISVVVIYFVFVIAVGIWSSIRASRGTIGGY
FLAGRSMSWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEWNMRKSRSGGDRGIHP
RSHGRTGVRSQATWLLLALGWVFVPVYIAAGVVTMPQYLKKRFGGQRIQVYMSVLSLILY
IFTKISTDIFSGALFIQMALGWNLYLSTGILLVVTAVYTIAGGLMAVIYTDALQTVIMVG
GALVLMFLGFQDVGWYPGLEQRYRQAIPNVTVPNTTCHLPRPDAFHILRDPVSGDIPWPG
LIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRAL
FPDEVGCVDPDVCQRICGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIF
NSSSTLFTIDVWQRFRRKSTEQELMVVGRVFVVFLVVISILWIPIIQSSNSGQLFDYIQA
VTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRMILEFSYPAPACGEVDRRP
AVLKDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTRLTWWTRNCPLSELEKEAHES
TPEISERPAGECPAGGGAAENSSLGQEQPEAPSRSWGKLLWSWFCGLSGTPEQALSPAEK
AALEQKLTSIEEEPLWRHVCNINAVLLLAINIFLWGYFA

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
699

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
76101

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
8.16

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
 Function:  transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00474:SSF

# Macromolecular_Interacting_Partner_8_Signals:
1-150

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
28-50; 81-103; 131-153; 174-196; 206-228; 233-255; 296-313; 334-356; 402-424; 445-467; 477-499; 506-528; 548-570; 679-698

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
56203824

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
Q5TET3_HUMAN (Q5TET3)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
SLC5A9

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
SLC5A9

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:22146

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>2100 bp
ATGGGGCCTGGAGCTTCAGGGGACGGGGTCAGGACTGAGACAGCTCCACACATAGCACTG
GACTCCAGAGTTGGTCTGCACGCCTACGACATCAGCGTGGTGGTCATCTACTTTGTCTTC
GTCATTGCTGTGGGGATCTGGTCGTCCATCCGTGCAAGTCGAGGGACCATTGGCGGCTAT
TTCCTGGCCGGGAGGTCCATGAGCTGGTGGCCAATTGGAGCATCTCTGATGTCCAGCAAT
GTGGGCAGTGGCTTGTTCATCGGCCTGGCTGGGACAGGGGCTGCCGGAGGCCTTGCCGTA
GGTGGCTTCGAGTGGAACATGAGGAAATCAAGGTCTGGAGGAGACAGAGGGATCCATCCA
AGGTCACACGGGAGGACTGGGGTCAGGTCCCAGGCAACCTGGCTGCTCCTGGCCCTTGGC
TGGGTCTTCGTCCCTGTGTACATCGCAGCAGGTGTGGTCACAATGCCGCAGTATCTGAAG
AAGCGATTTGGGGGCCAGAGGATCCAGGTGTACATGTCTGTCCTGTCTCTCATCCTCTAC
ATCTTCACCAAGATCTCGACTGACATCTTCTCTGGAGCCCTCTTCATCCAGATGGCATTG
GGCTGGAACCTGTACCTCTCCACAGGGATCCTGCTGGTGGTGACTGCCGTCTACACCATT
GCAGGTGGCCTCATGGCCGTGATCTACACAGATGCTCTGCAGACGGTGATCATGGTAGGG
GGAGCCCTGGTCCTCATGTTTCTGGGCTTTCAGGACGTGGGCTGGTACCCAGGCCTGGAG
CAGCGGTACAGGCAGGCCATCCCTAATGTCACAGTCCCCAACACCACCTGTCACCTCCCA
CGGCCCGATGCTTTCCACATTCTTCGGGACCCTGTGAGCGGGGACATCCCTTGGCCAGGT
CTCATTTTCGGGCTCACAGTGCTGGCCACCTGGTGTTGGTGCACAGACCAGGTCATTGTG
CAGCGGTCTCTCTCGGCCAAGAGTCTGTCTCATGCCAAGGGAGGCTCCGTGCTGGGGGGC
TACCTGAAGATCCTCCCCATGTTCTTCATCGTCATGCCTGGCATGATCAGCCGGGCCCTG
TTCCCAGACGAGGTGGGCTGCGTGGACCCTGATGTCTGCCAAAGAATCTGTGGGGCCCGA
GTGGGATGTTCCAACATTGCCTACCCTAAGTTGGTCATGGCCCTCATGCCTGTTGGTCTG
CGGGGGCTGATGATTGCCGTGATCATGGCCGCTCTCATGAGCTCACTCACCTCCATCTTC
AACAGCAGCAGCACCCTGTTCACCATTGATGTGTGGCAGCGCTTCCGCAGGAAGTCAACA
GAGCAGGAGCTGATGGTGGTGGGCAGAGTGTTTGTGGTGTTCCTGGTTGTCATCAGCATC
CTCTGGATCCCCATCATCCAAAGCTCCAACAGTGGGCAGCTCTTCGACTACATCCAGGCT
GTCACCAGTTACCTGGCCCCACCCATCACCGCTCTCTTCCTGCTGGCCATCTTCTGCAAG
AGGGTCACAGAGCCCGGAGCTTTCTGGGGCCTCGTGTTTGGCCTGGGAGTGGGGCTTCTG
CGTATGATCCTGGAGTTCTCATACCCAGCGCCAGCCTGTGGGGAGGTGGACCGGAGGCCA
GCAGTGCTGAAGGACTTCCACTACCTGTACTTTGCAATCCTCCTCTGCGGGCTCACTGCC
ATCGTCATTGTCATTGTCAGCCTCTGTACAACTCCCATCCCTGAGGAACAGCTCACACGC
CTCACATGGTGGACTCGGAACTGCCCCCTCTCTGAGCTGGAGAAGGAGGCCCACGAGAGC
ACACCGGAGATATCCGAGAGGCCAGCCGGGGAGTGCCCTGCAGGAGGTGGAGCGGCAGAG
AACTCGAGCCTGGGCCAGGAGCAGCCTGAAGCCCCAAGCAGGTCCTGGGGAAAGTTGCTC
TGGAGCTGGTTCTGTGGGCTCTCTGGAACACCGGAGCAGGCCCTGAGCCCAGCAGAGAAG
GCTGCGCTAGAACAGAAGCTGACAAGCATTGAGGAGGAGCCACTCTGGAGACATGTCTGC
AACATCAATGCTGTCCTTTTGCTGGCCATCAACATCTTCCTCTGGGGCTATTTTGCGTGA


# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
AL109659

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_8_Locus:
1p33

# Macromolecular_Interacting_Partner_8_SNPs:
rs850763; rs212989; rs12047252; rs212991; rs986027; rs2275698; rs1005538; rs2137831; rs4926518; rs11205458; rs11205459; rs764656; rs4926721; rs6670286; rs10788884; rs540944; rs12139099; rs4926720; rs12043455; rs12563106; rs7413497; rs6685450; rs11807747; rs2354005; rs1004833; rs705430; rs11809119; rs10888600; rs12126047; rs12118417; rs11205460; rs10489600; rs6694372; rs17104309; rs172480; rs212987; rs212986; rs6695408; rs12040115; rs12161316; rs7535096; rs41287930; rs41287932; rs17104299; rs12069452; rs12744691; rs11800306; rs36026942; rs28559882; rs12744574; rs35442116; rs177111; rs12123480; rs5773996; rs28548080; rs12119362; rs12130095; rs12081921; rs34216216; rs7554493; rs28637099; rs41287918; rs34855469; rs12738451; rs7415392; rs36053829; rs483937; rs1524734; rs12161552; rs5773999; rs28380281; rs35238707; rs7556499; rs34463054; rs35278010; rs35274475; rs41341650; rs28495806; rs5773998; rs212990; rs212988; rs35687593; rs34525597; rs7413495; rs35719528; rs34762012; rs12746335; rs41287922; rs12039311; rs34370455; rs34004627; rs212972; rs11205461; rs12026864; rs34445433; rs212984; rs212985; rs12746902; rs6695277; rs10430109; rs41287916; rs34039663; rs10788883; rs11205457; rs11802676; rs12081912; rs12120330; rs12739960; rs1524732; rs169880; rs1740106; rs1740107; rs212959; rs212961; rs212962; rs212963; rs212964; rs212965; rs212966; rs212970; rs2354002; rs490631; rs4926722; rs542281; rs550663; rs579416; rs705429; rs705432; rs850761; rs910621; rs926979; rs960721; rs960722

# Macromolecular_Interacting_Partner_8_General_References:
Not Available

# Macromolecular_Interacting_Partner_8_References:
Not Available

# Macromolecular_Interacting_Partner_9_ID:
8893

# Macromolecular_Interacting_Partner_9_Name:
Solute carrier family 2, facilitated glucose transporter member 8

# Macromolecular_Interacting_Partner_9_Synonyms:
Glucose transporter type 8; Glucose transporter type X1

# Macromolecular_Interacting_Partner_9_Gene_Name:
SLC2A8

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Solute carrier family 2, facilitated glucose transporter member 8
MTPEDPEETQPLLGPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPP
APRLDDAAASWFGAVVTLGAAAGGVLGGWLVDRAGRKLSLLLCSVPFVAGFAVITAAQDV
WMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVVGILLAYLAGWVLE
WRWLAVLGCVPPSLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLWGSEQGWEDPPIGAE
QSFHLALLRQPGIYKPFIIGVSLMAFQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGV
IQVLFTAVAALIMDRAGRRLLLVLSGVVMVFSTSAFGAYFKLTQGGPGNSSHVAISAPVS
AQPVDASVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWLM
AFLVTKEFSSLMEVLRPYGAFWLASAFCIFSVLFTLFCVPETKGKTLEQITAHFEGR

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
477

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
50820

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
7.68

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
 Function:  carrier activity
Function:  electrochemical potential-driven transporter activity
Function:  porter activity
Function:  sugar porter activity
Function:  transporter activity
Function:  carbohydrate transporter activity
Function:  sugar transporter activity
Function:  monosaccharide transporter activity
Function:  hexose transporter activity
Function:  glucose transporter activity
 ||
>>>
 Process:  carbohydrate transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_9_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_9_Specific_Function:
Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00083:Sugar_tr

# Macromolecular_Interacting_Partner_9_Signals:
1-41

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
26-46
71-91
97-117
128-148
157-177
183-203
257-277
293-313
320-340
368-388
405-425
439-459

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
7688146

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
GTR8_HUMAN (Q9NY64)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
SLC2A8

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
SLC2A8

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:13812

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Cell membrane; multi-pass membrane protein. Cytoplasmic vesicle; cytoplasmic vesicle membrane; multi-pass membrane protein (By similarity). Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration (By similarity)

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>1434 bp
ATGACGCCCGAGGACCCAGAGGAAACCCAGCCGCTTCTGGGGCCTCCTGGCGGCAGCGCG
CCCCGCGGCCGCCGCGTCTTCCTCGCCGCCTTCGCCGCTGCCCTGGGCCCACTCAGCTTC
GGCTTCGCGCTCGGCTACAGCTCCCCGGCCATCCCTAGCCTGCAGCGCGCCGCGCCCCCG
GCCCCGCGCCTGGACGACGCCGCCGCCTCCTGGTTCGGGGCTGTCGTGACCCTGGGTGCC
GCGGCGGGGGGAGTGCTGGGCGGCTGGCTGGTGGACCGCGCCGGGCGCAAGCTGAGCCTC
TTGCTGTGCTCCGTGCCCTTCGTGGCCGGCTTTGCCGTCATCACCGCGGCCCAGGACGTG
TGGATGCTGCTGGGGGGCCGCCTCCTCACCGGCCTGGCCTGCGGTGTTGCCTCCCTAGTG
GCCCCGGTCTACATCTCCGAAATCGCCTACCCAGCAGTCCGGGGGTTGCTCGGCTCCTGT
GTGCAGCTAATGGTCGTCGTCGGCATCCTCCTGGCCTACCTGGCAGGCTGGGTGCTGGAG
TGGCGCTGGCTGGCTGTGCTGGGCTGCGTGCCCCCCTCCCTCATGCTGCTTCTCATGTGC
TTCATGCCCGAGACCCCGCGCTTCCTGCTGACTCAGCACAGGCGCCAGGAGGCCATGGCC
GCCCTGCGGTTCCTGTGGGGCTCCGAGCAGGGCTGGGAAGACCCCCCCATCGGGGCTGAG
CAGAGCTTTCACCTGGCCCTGCTGCGGCAGCCCGGCATCTACAAGCCCTTCATCATCGGC
GTCTCCCTGATGGCCTTCCAGCAGCTGTCGGGGGTCAACGCCGTCATGTTCTATGCAGAG
ACCATCTTTGAAGAGGCCAAGTTCAAGGACAGCAGCCTGGCCTCGGTCGTCGTGGGTGTC
ATCCAGGTGCTGTTCACAGCTGTGGCGGCTCTCATCATGGACAGAGCAGGGCGGAGGCTG
CTCCTGGTCTTGTCAGGTGTGGTCATGGTGTTCAGCACGAGTGCCTTCGGCGCCTACTTC
AAGCTGACCCAGGGTGGCCCTGGCAACTCCTCGCACGTGGCCATCTCGGCGCCTGTCTCT
GCACAGCCTGTTGATGCCAGCGTGGGGCTGGCCTGGCTGGCCGTGGGCAGCATGTGCCTC
TTCATCGCCGGCTTTGCGGTGGGCTGGGGGCCCATCCCCTGGCTCCTCATGTCAGAGATC
TTCCCTCTGCATGTCAAGGGCGTGGCGACAGGCATCTGCGTCCTCACCAACTGGCTCATG
GCCTTTCTCGTGACCAAGGAGTTCAGCAGCCTCATGGAGGTCCTCAGGCCCTATGGAGCC
TTCTGGCTTGCCTCCGCTTTCTGCATCTTCAGTGTCCTTTTCACTTTTTCCTGTGTCCCT
GAAACTAAAGGAAAGACTCTGGAACAAATCACAGCCCATTTTGAGGGGCGATGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
Y17801

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_9_Locus:
9q33.3

# Macromolecular_Interacting_Partner_9_SNPs:
rs1138740; rs1138739; rs3088163; rs6635; rs3824414; rs3802364; rs3824413; rs3802368; rs10819287; rs11788710; rs4075850; rs3802367; rs3802363; rs4837150; rs11789887; rs11790967; rs3808835; rs3808838; rs3808839; rs10819288; rs3808836; rs7859247; rs10987632; rs41276194; rs34064803; rs36057295; rs34424745; rs3802366; rs4075298; rs7853132; rs5900746; rs35278243; rs34710554; rs35020051; rs28730350; rs35116441; rs41276196; rs10987637; rs34516407; rs10987633; rs10987635; rs13286516; rs10987636; rs12115375; rs28463013; rs41302651; rs41276192; rs7031934; rs3840734; rs3808840; rs11552814; rs3808837; rs35090919; rs11790936; rs10819289; rs10987630; rs10987639; rs10987640; rs1127518; rs35789340; rs4074695; rs7047760; rs7848126; rs7864853; rs7873847

# Macromolecular_Interacting_Partner_9_General_References:
10821868; 10671487

# Macromolecular_Interacting_Partner_9_References:
Not Available

End of HMDB00143

Beginning of HMDB00145
# Accession_No:
HMDB00145

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-05-23 13:38:49

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Estrone

# Description:
An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.

# Synonyms:
(+)-Estrone; 1,3,5(10)-Estratrien-3-ol-17-one; 3-Hydroxy-17-keto-estra-1,3,5-triene; 3-Hydroxyestra-1,3,5(10)-trien-17-one; 3-Hydroxyestra-1,3,5(10)-triene-17-one; 3-Hydroxyoestra-1,3,5(10)-trien-17-one; D1,3,5(10)-Estratrien-3-ol-17-one

# Chemical_IUPAC_Name:
3-hydroxy-Estra-1,3,5(10)-trien-17-one

# Chemical_Formula:
C18H22O2

# Chemical_Structure:
tbl_chemical:::HMDB00145_ZOOM.png:::119283216180353950

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00145_THUMB.png:::119283215986062445

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Steroids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
ketone; phenol or hydroxyhetarene; aromatic compound

# Taxonomy_Biofunction:
Component of Androgen and estrogen metabolism; Component of Sulfur metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
270.16199

# Molecular_Weight_Avg:
270.36609

# Smiles_String_isomeric:
C[C@]12CC[C@H]3[C@@H](CCC4=C3C=CC(O)=C4)[C@@H]1CCC2=O

# Smiles_String_canonical:
CC12CCC3C(CCC4=C3C=CC(O)=C4)C1CCC2=O

# KEGG_Compound_ID:
C00468

# BioCyc_ID:
ESTRONE

# PubChem_CID:
5870

# PubChem_SID:
7988426; 8144215; 7847135; 3751; 8153628; 7979191; 11468062; 855919; 148674; 11486713; 11466942; 841396; 613807; 3133155; 7854792

# OMIM_ID:
107910; 114550; 139300; 264300

# Metagene_ID:
Not Available

# BiGG_ID:
35059

# Wikipedia_ID:
Estrone

# METLIN_ID:
264

# Ref_ID:
10997942; 16598814

# ChEBI_ID:
17263

# CAS_Registry_Number:
53-16-7

# InChI:
InChI=1/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1

# Synthesis_Reference:
Canadian Journal of Chemistry  (1953),  31  514-17.

# Melting_Point:
258-260oC

# Melting_Point_predicted:
122.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.03 mg/mL [MERCK INDEX (1996)]

# H2O_Solubility_Predicted:
3.94e-03 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
3.13 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
4.03 [Predicted by ALOGPS]; 3.6 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Estrone.mol:::1132723809953520819

# SDF_File_[Text]:
tbl_chemical:::HMDB00145.sdf:::119283215297194333

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00145.pdb:::119283215851488648

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::Estrone_00145_CDCl3_noesy1d_1feb07.fid.zip:::117087227671967489

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:


# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Estrone.gif:::1132732113781791208

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00145_peaks.txt:::1156309574120375432

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Estrone_C.gif:::1132737699117494766

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00145_peaks.txt:::1156310763998600608

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane (Predicted from LogP); Cytoplasm; endoplasmic reticulum

# Tissue_Location:
Liver

# deuterated:
No

# Biofluid_Location:
Bile; Blood

# Concentration_[Normal]:
Blood	0.00020 (0.00011-0.00030)	umol/L	Adult:>18_yrs_old	Male	Normal	Merck Manual


# Concentration_[Abnormal]:
Blood	0.00035 (0.00014-0.00056)	umol/L	Adult:>18_yrs_old	Female	Female Follicular phase	Merck Manual
Blood	0.00050 (0.00028-0.00074)	umol/L	Adult:>18_yrs_old	Both	Female Midcycle	Merck Manual
Blood	0.00030 (0.00018-0.00042)	umol/L	Adult:>18_yrs_old	Both	Female Luteal phase	Merck Manual
Blood	<=0.00024	umol/L	Adult:>18_yrs_old	Female	Postmenopausal	Merck Manual


# Associated_Disorders:
Breast Cancer; Endometrial Cancer; Female Follicular phase; Female Luteal phase; Female Midcycle; Polycystic Ovary Syndrome (PCOS); Postmenopausal

# Pathway_Names:
Pentose and glucuronate interconversions;Androgen and estrogen metabolism;Starch and sucrose metabolism;Porphyrin and chlorophyll metabolism;Fatty acid biosynthesis (path 2);Fatty acid metabolism;Valine, leucine and isoleucine degradation;Lysine degradation;Benzoate degradation via CoA ligation;Butanoate metabolism;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
;;;;;;valine,leucine,and_isoleucine_degradation.jpg;Lysine_degradation.jpg;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00040;map00150;map00500;map00860;map00062;map00071;map00280;map00310;map00632;map00650;map00280;map00280

# Pathway_Graphs:
;;;;;;valine,leucine,and_isoleucine_degradation_Graph.jpg;Lysine_degradation_Graph.jpg;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
;;;;;;valine,leucine,and_isoleucine_degradation.xml;Lysine_degradation.xml;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5732

# Metabolic_Enzyme_1_Name:
UDP-glucuronosyltransferase 1-6 precursor

# Metabolic_Enzyme_1_Synonyms:
UDP- glucuronosyltransferase 1A6; UDPGT; UGT1*6; UGT1-06; UGT1.6; UGT- 1F; UGT1F; Phenol-metabolizing UDP-glucuronosyltransferase

# Metabolic_Enzyme_1_Gene_Name:
UGT1A6

# Metabolic_Enzyme_1_Protein_Sequence:
>UDPglucuronosyltransferase 16 precursor
MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVV
PEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIG
LYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEH
TFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRD
VDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHG
IVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLL
GHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSE
DLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDL
TWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_1_Number_of_Residues:
532

# Metabolic_Enzyme_1_Molecular_Weight:
60751

# Metabolic_Enzyme_1_Theoretical_pI:
8.55

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols

# Metabolic_Enzyme_1_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_1_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_1_Signals:
1-26

# Metabolic_Enzyme_1_Transmembrane_Regions:
490-506

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_1_GenBank_ID_Protein:
340141

# Metabolic_Enzyme_1_SwissProt_ID:
UD16_HUMAN (P19224)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
UGT1A6

# Metabolic_Enzyme_1_Geneatlas_id:
UGT1A6

# Metabolic_Enzyme_1_hgnc_id:
HGNC:12538

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Microsome

# Metabolic_Enzyme_1_Gene_Sequence:
>861 bp
ATGGCCTGCCTCCTTCGCTCATTTCAGAGAATTTCTGCAGGGGTTTTCTTCTTAGCACTT
TGGGGCATGGTTGTAGGTGACAAGCTGCTGGTGGTCCCTCAGGACGGAAGCCACTGGCTT
AGTATGAAGGATATAGTTGAGGTTCTCAGTGACCGGGGTCATGAGATTGTAGTGGTGGTG
CCTGAAGTTAATTTGCTTTTGAAAGAATCCAAATACTACACAAGAAAAATCTATCCAGTG
CCGTATGACCAAGAAGAGCTGAAGAACCGTTACCAATCATTTGGAAACAATCACTTTGCT
GAGCGATCATTCCTAACTGCTCCTCAGACAGAGTACAGGAATAACATGATTGTTATTGGC
CTGTACTTCATCAACTGCCAGAGCCTCCTGCAGGACAGGGACACCCTGAACTTCTTTAAG
GAGAGCAAGTTTGATGCTCTTTTCACAGACCCAGCCTTACCCTGTGGGGTGATCCTGGCT
GAGTATTTGGGCCTACCATCTGTGTACCTCTTCAGGGGTTTTCCGTGTTCCCTGGAGCAT
ACATTCAGCAGAAGCCCAGACCCTGTGTCCTACATTCCCAGGTGCTACACAAAGTTTTCA
GACCACATGACTTTTTCCCAACGAGTGGCCAACTTCCTTGTTAATTTGTTGGAGCCCTAT
CTATTTTATTGTCTGTTTTCAAAGTATGAAGAACTCGCATCAGCTGTCCTCAAGAGAGAT
GTGGATATAATCACCTTATATCAGAAGGTCTCTGTTTGGCTGTTAAGATATGACTTTGTG
CTTGAATATCCTAGGCCGGTCATGCCCAACATGGTCTTCATTGGAGGTATCAACTGTAAG
AAGAGGAAAGACTTGTCTCAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M84130

# Metabolic_Enzyme_1_Chromosome_Location:
Not Available

# Metabolic_Enzyme_1_Locus:
Not Available

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
1339448; 3141926; 11434514; 9466822; 9429234

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5722

# Metabolic_Enzyme_2_Name:
UDP-glucuronosyltransferase 2B15 precursor

# Metabolic_Enzyme_2_Synonyms:
UDPGT; UDPGTh-3; HLUG4

# Metabolic_Enzyme_2_Gene_Name:
UGT2B15

# Metabolic_Enzyme_2_Protein_Sequence:
>UDPglucuronosyltransferase 2B15 precursor
MSLKWTSVFLLIQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVTVLTSSA
STLVNASKSSAIKLEVYPTSLTKNDLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEY
YDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGELLAELFNIPFLYSLRFSVGYT
FEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYSEV
LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
MSSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVA
AHNLTWIQYHSLDVIAFLLACVATVIFIITKFCLFCFRKLAKKGKKKKRD

# Metabolic_Enzyme_2_Number_of_Residues:
530

# Metabolic_Enzyme_2_Molecular_Weight:
60989

# Metabolic_Enzyme_2_Theoretical_pI:
9.04

# Metabolic_Enzyme_2_GO_Classification:
Not Available

# Metabolic_Enzyme_2_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens

# Metabolic_Enzyme_2_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_2_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_2_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_2_Signals:
1-23

# Metabolic_Enzyme_2_Transmembrane_Regions:
495-515

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_2_GenBank_ID_Protein:
23955933

# Metabolic_Enzyme_2_SwissProt_ID:
UDB15_HUMAN (P54855)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
UGT2B15

# Metabolic_Enzyme_2_Geneatlas_id:
UGT2B15

# Metabolic_Enzyme_2_hgnc_id:
HGNC:12546

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Microsome

# Metabolic_Enzyme_2_Gene_Sequence:
>1593 bp
ATGTCTCTGAAATGGACGTCAGTCTTTCTGCTGATACAGCTCAGTTGTTACTTTAGCTCT
GGAAGCTGTGGAAAGGTGCTAGTGTGGCCCACAGAATACAGCCATTGGATAAATATGAAG
ACAATCCTGGAAGAGCTTGTTCAGAGGGGTCATGAGGTGACTGTGTTGACATCTTCGGCT
TCTACTCTTGTCAATGCCAGTAAATCATCTGCTATTAAATTAGAAGTTTATCCTACATCT
TTAACTAAAAATGATTTGGAAGATTCTCTTCTGAAAATTCTCGATAGATGGATATATGGT
GTTTCAAAAAATACATTTTGGTCATATTTTTCACAATTACAAGAATTGTGTTGGGAATAT
TATGACTACAGTAACAAGCTCTGTAAAGATGCAGTTTTGAATAAGAAACTTATGATGAAA
CTACAAGAGTCAAAGTTTGATGTCATTCTGGCAGATGCCCTTAATCCCTGTGGTGAGCTA
CTGGCTGAACTATTTAACATACCCTTTCTGTACAGTCTTCGATTCTCTGTTGGCTACACA
TTTGAGAAGAATGGTGGAGGATTTCTGTTCCCTCCTTCCTATGTACCTGTTGTTATGTCA
GAATTAAGTGATCAAATGATTTTCATGGAGAGGATAAAAAATATGATACATATGCTTTAT
TTTGACTTTTGGTTTCAAATTTATGATCTGAAGAAGTGGGACCAGTTTTATAGTGAAGTT
CTAGGAAGACCCACTACATTATTTGAGACAATGGGGAAAGCTGAAATGTGGCTCATTCGA
ACCTATTGGGATTTTGAATTTCCTCGCCCATTCTTACCAAATGTTGATTTTGTTGGAGGA
CTTCACTGTAAACCAGCCAAACCCCTGCCTAAGGAAATGGAAGAGTTTGTGCAGAGCTCT
GGAGAAAATGGTATTGTGGTGTTTTCTCTGGGGTCGATGATCAGTAACATGTCAGAAGAA
AGTGCCAACATGATTGCATCAGCCCTTGCCCAGATCCCACAAAAGGTTCTATGGAGATTT
GATGGCAAGAAGCCAAATACTTTAGGTTCCAATACTCGACTGTACAAGTGGTTACCCCAG
AATGACCTTCTTGGTCATCCCAAAACCAAAGCTTTTATAACTCATGGTGGAACCAATGGC
ATCTATGAGGCGATCTACCATGGGATCCCTATGGTGGGCATTCCCTTGTTTGCGGATCAA
CATGATAACATTGCTCACATGAAAGCCAAGGGAGCAGCCCTCAGTGTGGACATCAGGACC
ATGTCAAGTAGAGATTTGCTCAATGCATTGAAGTCAGTCATTAATGACCCTGTCTATAAA
GAGAATGTCATGAAATTATCAAGAATTCATCATGACCAACCAATGAAGCCCCTGGATCGA
GCAGTCTTCTGGATTGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTTCGAGTCGCA
GCTCACAACCTCACCTGGATCCAGTACCACTCTTTGGATGTGATAGCATTCCTGCTGGCC
TGCGTGGCAACTGTGATATTTATCATCACAAAATTTTGCCTGTTTTGTTTCCGAAAGCTT
GCCAAAACAGGAAAGAAGAAGAAAAGAGATTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF548389

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_2_Locus:
4q13

# Metabolic_Enzyme_2_SNPs:
rs6825560; rs988562; rs1120265; rs1960773; rs7686914; rs988560; rs6839555; rs7682027; rs3100; rs9994887; rs1580083; rs7377952; rs7696472; rs6825748; rs13128530; rs1968719; rs1968718; rs7654523; rs1026337; rs1947435; rs1026338; rs2278917; rs1160212; rs12500760; rs4048844; rs7377954; rs12647504; rs4148271; rs2168050; rs2168051; rs6858676; rs35791822; rs13112099; rs7377950; rs34930215; rs17324486; rs5017546; rs2877378; rs1947434; rs5017549; rs17221777; rs35601514; rs6839657; rs11371462; rs5017544; rs2331421; rs2331422; rs6820752; rs4694747; rs12108552; rs34214136; rs4426857; rs35503231; rs5017548; rs35397066; rs5859136; rs2877377; rs10549990; rs2331423; rs5017545; rs34618890; rs5017547; rs5029385; rs1026339; rs5859137; rs34498614; rs34207963; rs3966095; rs1902023; rs4148269

# Metabolic_Enzyme_2_General_References:
7835232; 9295060; 2116769

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5557

# Metabolic_Enzyme_3_Name:
Arylsulfatase B precursor

# Metabolic_Enzyme_3_Synonyms:
ASB; N-acetylgalactosamine- 4-sulfatase; G4S

# Metabolic_Enzyme_3_Gene_Name:
ARSB

# Metabolic_Enzyme_3_Protein_Sequence:
>Arylsulfatase B precursor
MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV
GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS
CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER
CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS
VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD
NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL
ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP
EYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRD
PEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM

# Metabolic_Enzyme_3_Number_of_Residues:
533

# Metabolic_Enzyme_3_Molecular_Weight:
59688

# Metabolic_Enzyme_3_Theoretical_pI:
8.31

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  sulfuric ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Hydrolysis of the 4-sulfate groups of the N- acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate

# Metabolic_Enzyme_3_Pathway:
map00531  Glycosaminoglycan degradation

# Metabolic_Enzyme_3_Reaction:
Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00884:Sulfatase

# Metabolic_Enzyme_3_Signals:
1-36

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.1.6.12

# Metabolic_Enzyme_3_GenBank_ID_Protein:
179077

# Metabolic_Enzyme_3_SwissProt_ID:
ARSB_HUMAN (P15848)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ARSB

# Metabolic_Enzyme_3_Geneatlas_id:
ARSB

# Metabolic_Enzyme_3_hgnc_id:
HGNC:714

# Metabolic_Enzyme_3_PDB_ID:
1FSU

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_3_Gene_Sequence:
>1602 bp
ATGGGTCCGCGCGGCGCGGCGAGCTTGCCCCGAGGCCCCGGACCTCGGCGGCTGCTCCTC
CCCGTCGTCCTCCCGCTGCTGCTGCTGCTGTTGTTGGCGCCGCCGGGCTCGGGCGCCGGG
GCCAGCCGGCCGCCCCACCTGGTCTTCTTGCTGGCAGACGACCTAGGCTGGAACGACGTC
GGCTTCCACGGCTCCCGCATCCGCACGCCGCACCTGGACGCGCTGGCGGCCGGCGGGGTG
CTCCTGGACAACTACTACACGCAGCCGCTGTGCACGCCGTCGCGGAGCCAGCTGCTCACT
GGCCGCTACCAGATCCGTACAGGTTTACAGCACCAAATAATCTGGCCCTGTCAGCCCAGC
TGTGTTCCTCTGGATGAAAAACTCCTGCCCCAGCTCCTAAAAGAAGCAGGTTATACTACC
CATATGGTCGGAAAATGGCACCTGGGAATGTACCGGAAAGAATGCCTTCCAACCCGCCGA
GGATTTGATACCTACTTTGGATATCTCCTGGGTAGTGAAGATTATTATTCCCATGAACGC
TGTACATTAATTGACGCTCTGAATGTCACACGATGTGCTCTTGATTTTCGAGATGGCGAA
GAAGTTGCAACAGGATATAAAAATATGTATTCAACAAACATATTCACCAAAAGGGCTATA
GCCCTCATAACTAACCATCCACCAGAGAAGCCTCTGTTTCTCTACCTTGCTCTCCAGTCT
GTGCATGAGCCCCTTCAGGTCCCTGAGGAATACTTGAAGCCATATGACTTTATCCAAGAC
AAGAACAGGCATCACTATGCAGGAATGGTGTCCCTTATGGATGAAGCAGTAGGAAATGTC
ACTGCAGCTTTAAAAAGCAGTGGGCTCTGGAACAACACGGTGTTCATCTTTTCTACAGAT
AACGGAGGGCAGACTTTGGCAGGGGGTAATAACTGGCCCCTTCGAGGAAGAAAATGGAGC
CTGTGGGAAGGAGGCGTCCGAGGGGTGGGCTTTGTGGCAAGCCCCTTGCTGAAGCAGAAG
GGCGTGAAGAACCGGGAGCTCATCCACATCTCTGACTGGCTGCCAACACTCGTGAAGCTG
GCCAGGGGACACACCAATGGCACAAAGCCTCTGGATGGCTTCGACGTGTGGAAAACCATC
AGTGAAGGAAGCCCATCCCCCAGAATTGAGCTGCTGCATAATATTGACCCAAACTTCGTG
GACTCTTCACCGTGTCCCAGGAACAGCATGGCTCCAGCAAAGGATGACTCTTCTCTTCCA
GAATATTCAGCCTTTAACACATCTGTCCATGCTGCAATTAGACATGGAAATTGGAAACTC
CTCACGGGCTACCCAGGCTGTGGTTACTGGTTCCCTCCACCGTCTCAATACAATGTTTCT
GAGATACCCTCATCAGACCCACCAACCAAGACCCTCTGGCTCTTTGATATTGATCGGGAC
CCTGAAGAAAGACATGACCTGTCCAGAGAATATCCTCACATCGTCACAAAGCTCCTGTCC
CGCCTACAGTTCTACCATAAACACTCAGTCCCCGTGTACTTCCCTGCACAGGACCCCCGC
TGTGATCCCAAGGCCACTGGGGTGTGGGGCCCTTGGATGTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
J05225

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_3_Locus:
5p11-q13|5q11-q13

# Metabolic_Enzyme_3_SNPs:
rs17220759; rs25414; rs1065757; rs25413; rs35757003; rs16876029; rs7704939; rs754567; rs754566; rs3088247; rs11750774; rs2173012; rs163127; rs163126; rs3098701; rs337865; rs234687; rs97729; rs337827; rs378912; rs337887; rs163215; rs339027; rs163299; rs337883; rs337826; rs338465; rs449839; rs7737068; rs378944; rs337879; rs3098678; rs3797550; rs2052550; rs337895; rs2925727; rs10039384; rs11960862; rs337852; rs3857405; rs337847; rs10474569; rs6453415; rs4704531; rs3098683; rs421734; rs10078690; rs9293758; rs7702409; rs6870550; rs337888; rs3846677; rs6453421; rs337851; rs7731315; rs337845; rs234910; rs3098679; rs4703768; rs12522844; rs337884; rs6874580; rs12658000; rs6887109; rs672413; rs4704535; rs6897944; rs7708387; rs337836; rs6863277; rs337885; rs10462560; rs3114495; rs7732099; rs11740104; rs186818; rs337846; rs4704534; rs337867; rs6453423; rs163216; rs4704530; rs7713155; rs751508; rs11743362; rs6887407; rs338460; rs6871810; rs921945; rs7717470; rs918580; rs4704525; rs447998; rs376749; rs10474567; rs337849; rs339032; rs337843; rs3114494; rs4704533; rs426586; rs784586; rs3852190; rs168091; rs10053925; rs1402684; rs180047; rs337853; rs6453420; rs10805924; rs7722869; rs7727110; rs4421085; rs7721866; rs7736777; rs10052939; rs3114493; rs10452492; rs559088; rs11747224; rs337844; rs3114492; rs6859069; rs12655291; rs16876147; rs3098695; rs3846679; rs16876062; rs7709486; rs10942879; rs97728; rs337835; rs336520; rs17219410; rs337875; rs6865582; rs16876106; rs3869024; rs163214; rs163128; rs2020404; rs6890245; rs6871197; rs414063; rs16875951; rs16875919; rs180295; rs3098681; rs6870443; rs6891547; rs10942870; rs180049; rs339030; rs3869025; rs32962; rs12054837; rs7710725; rs338458; rs6895479; rs189269; rs11739303; rs430185; rs10058204; rs3857404; rs6453417; rs337832; rs10942880; rs11748603; rs11957735; rs3098698; rs12655738; rs4704542; rs6861970; rs4704532; rs337841; rs4521454; rs3910652; rs413209; rs6876288; rs11738153; rs339034; rs11953253; rs337863; rs730836; rs7712469; rs6893857; rs11740161; rs12186484; rs3797556; rs6896300; rs337862; rs337833; rs10454896; rs338457; rs16875913; rs6890675; rs337877; rs784587; rs3114500; rs10045962; rs10805923; rs653413; rs12109559; rs17220863; rs3869026; rs7704725; rs16875940; rs10058261; rs337859; rs10514108; rs10942881; rs163129; rs3797552; rs337864; rs10514114; rs11740160; rs6888024; rs16875961; rs10044989; rs2919650; rs516908; rs7701898; rs10454897; rs16876110; rs337829; rs6895995; rs3869022; rs7706434; rs7725928; rs337850; rs2052549; rs3822473; rs11742709; rs12186766; rs3797554; rs427501; rs12654847; rs7711802; rs17818103; rs11741352; rs337876; rs6894968; rs17221983; rs7719520; rs12153089; rs339036; rs234688; rs9687996; rs10942868; rs4704524; rs3098680; rs6883131; rs12659281; rs339029; rs6898549; rs485142; rs337857; rs10462562; rs7730428; rs337834; rs10040033; rs339031; rs2043985; rs7724023; rs193123; rs16876057; rs3906812; rs17819357; rs10454895; rs427984; rs13340404; rs6897347; rs9632425; rs17820610; rs10064655; rs11955485; rs6453419; rs6860821; rs3098686; rs10039336; rs337840; rs12187930; rs12656514; rs11746751; rs11742408; rs784589; rs16876111; rs10042060; rs7705217; rs337828; rs671947; rs11748914; rs4447961; rs4470743; rs6453416; rs16876146; rs337881; rs339035; rs17221292; rs3098700; rs4703764; rs10805921; rs4704537; rs3098699; rs3822575; rs10055350; rs16876043; rs6870085; rs337856; rs337891; rs2919651; rs10039309; rs337860; rs9885048; rs191416; rs1866841; rs10942867; rs13184327; rs337886; rs16875905; rs16876115; rs11743827; rs12109126; rs7731288; rs336521; rs7729335; rs10755301; rs337878; rs184614; rs163130; rs784581; rs595479; rs7731568; rs17819944; rs9763635; rs13179571; rs4704528; rs10040776; rs3114501; rs337866; rs4704526; rs918581; rs10942872; rs650304; rs182880; rs11741182; rs17819603; rs688180; rs10040460; rs12658420; rs1866842; rs11749494; rs3822576; rs10462563; rs572281; rs784585; rs16875944; rs16876155; rs484234; rs16876279; rs11956583; rs16876048; rs180296; rs12654412; rs16875947; rs6887828; rs1583875; rs6897315; rs2919649; rs2099786; rs4704541; rs7731086; rs12109527; rs17218427; rs13185621; rs13177084; rs594686; rs784584; rs10462564; rs35676576; rs1899248; rs11739567; rs3098697; rs12515765; rs4515284; rs16876047; rs380061; rs16876045; rs12522377; rs6869313; rs9686232; rs3733895; rs3098684; rs11742860; rs12108732; rs3098692; rs17817904; rs3822577; rs10805922; rs337842; rs17818235; rs10942882; rs336523; rs13172853; rs13152961; rs2043984; rs16876063; rs339033; rs11740887; rs9765665; rs381184; rs337858; rs12656053; rs338462; rs7713152; rs10942877; rs12108960; rs11746011; rs337893; rs7730261; rs12109507; rs16875952; rs11744095; rs11739786; rs6887812; rs12187361; rs11957876; rs12515760; rs12108766; rs10040315; rs10942869; rs17819273; rs339028; rs6896262; rs16876044; rs11956904; rs3114497; rs12519566; rs9763091; rs11746616; rs7705475; rs12519881; rs16876150; rs337882; rs10072794; rs12188734; rs3822574; rs337830; rs16875946; rs11958663; rs16875902; rs13172903; rs337890; rs16875918; rs13184587; rs3951714; rs10040592; rs3114498; rs12522878; rs921944; rs10942878; rs7705181; rs16875949; rs17819429; rs337892; rs3098682; rs13178105; rs25415; rs12187584; rs7714654; rs9763629; rs12188045; rs10474568; rs12522380; rs12658374; rs7732938; rs163125; rs163124; rs16875887; rs10035905; rs7701438; rs7705926; rs1610960; rs34555226; rs613384; rs35714924; rs34610517; rs35597782; rs3075605; rs11424557; rs34152768; rs1079397; rs35905702; rs35583050; rs13354324; rs34833402; rs34139618; rs10036464; rs35220263; rs34215850; rs12653482; rs36036266; rs35130512; rs1717569; rs6862341; rs34830838; rs337889; rs34834944; rs34302981; rs9687115; rs13174426; rs35534569; rs34064696; rs10044381; rs337870; rs35317295; rs9799972; rs13156857; rs688286; rs35371175; rs41380947; rs34208828; rs28376183; rs28880323; rs35365107; rs13356043; rs35320861; rs34239164; rs519616; rs34498684; rs34056138; rs337831; rs35128236; rs34740869; rs35008584; rs34764801; rs34879488; rs16875915; rs28469385; rs35036564; rs35466881; rs35603282; rs13186087; rs34854556; rs34707299; rs338459; rs35697969; rs10044323; rs7707781; rs11387576; rs34904434; rs36187313; rs4704527; rs337873; rs13156748; rs1583874; rs13178011; rs35847346; rs784582; rs13161164; rs35689064; rs11750390; rs10574411; rs35368627; rs35436989; rs34148796; rs34805908; rs3857402; rs34209322; rs36189781; rs35548234; rs35433236; rs35038707; rs34923760; rs36189850; rs34264126; rs7736871; rs35281545; rs5868942; rs35103058; rs34155346; rs36034813; rs34432678; rs36176060; rs35285216; rs35428296; rs36186839; rs34917607; rs4133641; rs7448396; rs35839419; rs34033767; rs2547907; rs4704523; rs13155848; rs28520051; rs35667232; rs7702582; rs34499731; rs573979; rs35701136; rs337869; rs34341146; rs35588382; rs34032086; rs34346174; rs34857061; rs10474571; rs3098694; rs35285752; rs34026363; rs11747782; rs34338496; rs3098687; rs12109560; rs7700275; rs35740556; rs35013980; rs3797551; rs10942871; rs34768794; rs10474003; rs550807; rs2547909; rs34687985; rs7727489; rs337894; rs3114499; rs337839; rs337861; rs4021352; rs36162527; rs10618582; rs10574410; rs35363304; rs35681509; rs3114491; rs9632424; rs35911170; rs13166469; rs3035252; rs11746064; rs36144584; rs13155460; rs34737292; rs13181496; rs34368935; rs34755254; rs3886615; rs13176597; rs28370903; rs35116666; rs7722223; rs1092386; rs16875916; rs35201819; rs35893550; rs638060; rs36027876; rs16876023; rs34309008; rs35089219; rs12656441; rs4703763; rs12187354; rs10697601; rs35332751; rs638073; rs10942876; rs2547906; rs16876000; rs34259925; rs33970298; rs36191751; rs10594012; rs813049; rs337855; rs12109658; rs34574941; rs35025964; rs189804; rs34888064; rs2919652; rs3898436; rs539740; rs10053510; rs34533204; rs7703105; rs7735667; rs337880; rs235041; rs35496004; rs11413324; rs28673689; rs35400790; rs34402312; rs28405288; rs2197000; rs34040242; rs11743312; rs336524; rs6862636; rs394636; rs3098693; rs547170; rs35834955; rs13181505; rs34503367; rs11394259; rs10636559; rs337872; rs34595444; rs4703767; rs34055862; rs10551103; rs28634712; rs11268991; rs3899213; rs34105402; rs35730374; rs34714631; rs180048; rs13155497; rs34990932; rs10053225; rs11954358; rs13177269; rs3839268; rs34445419; rs28635990; rs11355138; rs13176594; rs337837; rs36197411; rs13181497; rs13172645; rs1091882; rs1692205; rs10045716; rs34469310; rs7724106; rs35262260; rs11299499; rs34034331; rs2197002; rs7709470; rs163131; rs35846655; rs34571367; rs2363609; rs337854; rs34898219; rs13177451; rs364620; rs9799962; rs34450984; rs36230002; rs35559177; rs12234098; rs34037585; rs13173889; rs36062148; rs13176845; rs10590311; rs34205498; rs35872703; rs35439643; rs11394958; rs35261341; rs35462751; rs35654714; rs34127515; rs1841991; rs11959213; rs10042203; rs16875943; rs12188269; rs35319484; rs337871; rs784588; rs35631654; rs1020186; rs7711919; rs10713151; rs34955466; rs35241200; rs34046420; rs10474002; rs3898435; rs34632923; rs35516786; rs35783391; rs36182430; rs6873893; rs4703766; rs9800277; rs36099030; rs10462561; rs13190257; rs35605269; rs10060752; rs6867149; rs3098688; rs34768660; rs186836; rs34706909; rs34688578; rs4482882; rs7717318; rs479148; rs35661103; rs35665104; rs35093883; rs13188817; rs34991706; rs7733057; rs5868940; rs10715023; rs13159135; rs11355139; rs6898498; rs1717570; rs7704110; rs35800814; rs35393927; rs3839269; rs894063; rs36146674; rs337868; rs13154740; rs13162166; rs36181206; rs337838; rs35626755; rs235042; rs10713491; rs7706760; rs35397898; rs189258; rs35719104; rs4704540; rs34902218; rs12153761; rs28693862; rs10683109; rs10057066; rs33943364; rs3035249; rs35928774; rs3857403; rs640837; rs3846678; rs4703765; rs35005469; rs2197001; rs34960858; rs8180446; rs7718164; rs34743994; rs10942874; rs35271764; rs35140194; rs12233989; rs36112811; rs3098685; rs10718349; rs2582725; rs4579229; rs10551102; rs7710146; rs35321003; rs9686894; rs35782121; rs5868939; rs34757674; rs34686491; rs486880; rs336522; rs28710792; rs34249973; rs35403493; rs36177025; rs35632995; rs35367883; rs34679554; rs11959212; rs7703437; rs34624505; rs11339765; rs6863008; rs784583; rs28366694; rs337874; rs35743244; rs36172998; rs4623130; rs35365110; rs34562530; rs34239279; rs34607195; rs183509; rs4133640; rs11750483; rs3098689; rs13181535; rs35596391; rs10525745; rs16876144; rs34302396; rs7716141; rs3889702; rs12655680; rs34833921; rs5868941; rs11440743; rs28616200; rs35516119; rs13178897; rs12189199; rs9885047; rs34367819; rs35644734; rs35377010; rs34286642; rs2547908; rs34960514; rs2112908; rs7701762; rs500390; rs35791513; rs35715333; rs34899252; rs34802644; rs13159416; rs35765094; rs7721596; rs13183099; rs13179012; rs497520; rs34221362; rs6887176; rs11272168; rs11308364; rs34016781; rs10068924; rs10514156; rs10942866; rs11742892; rs11747027; rs152727; rs163132; rs163133; rs17218031; rs2020368; rs2029904; rs2132537; rs336525; rs336526; rs337848; rs402208; rs4704521; rs478651; rs663646; rs6863289; rs6863492; rs705415; rs7702025; rs9293761

# Metabolic_Enzyme_3_General_References:
2303452; 1968043; 7687847; 1930244; 1390929; 7628016; 9032078; 1718978; 1550123; 8116615; 8125475; 8541342; 8651289; 9582121; 10036316; 11802522

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5731

# Metabolic_Enzyme_4_Name:
UDP-glucuronosyltransferase 2B17 precursor

# Metabolic_Enzyme_4_Synonyms:
UDPGT; C19- steroid-specific UDP-glucuronosyltransferase

# Metabolic_Enzyme_4_Gene_Name:
UGT2B17

# Metabolic_Enzyme_4_Protein_Sequence:
>UDPglucuronosyltransferase 2B17 precursor
MSLKWMSVFLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSA
SILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEY
SDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYT
VEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEV
LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
MSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVA
AHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLFCFRKLAKTGKKKKRD

# Metabolic_Enzyme_4_Number_of_Residues:
530

# Metabolic_Enzyme_4_Molecular_Weight:
61096

# Metabolic_Enzyme_4_Theoretical_pI:
8.73

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3alpha,17beta-diol (3alpha-diol) > testosterone > androsterone (ADT)

# Metabolic_Enzyme_4_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_4_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_4_Signals:
1-23

# Metabolic_Enzyme_4_Transmembrane_Regions:
495-515

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_4_GenBank_ID_Protein:
3287473

# Metabolic_Enzyme_4_SwissProt_ID:
UDB17_HUMAN (O75795)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
UGT2B17

# Metabolic_Enzyme_4_Geneatlas_id:
UGT2B17

# Metabolic_Enzyme_4_hgnc_id:
HGNC:12547

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Microsome

# Metabolic_Enzyme_4_Gene_Sequence:
>1593 bp
ATGTCTCTGAAATGGATGTCAGTCTTTCTGCTGATGCAGCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATACAGCCATTGGATAAATATGAAG
ACAATCCTGGAAGAGCTTGTTCAGAGGGGTCATGAGGTGATTGTGTTGACATCTTCGGCT
TCTATTCTTGTCAATGCCAGTAAATCATCTGCTATTAAATTAGAAGTTTATCCTACATCT
TTAACTAAAAATGATTTGGAAGATTTTTTTATGAAAATGTTCGATAGATGGACATATAGT
ATTTCAAAAAATACATTTTGGTCATATTTTTCACAACTACAAGAATTGTGTTGGGAATAT
TCTGACTATAATATAAAGCTCTGTGAAGATGCAGTTTTGAACAAGAAACTTATGAGAAAA
CTACAAGAGTCAAAATTTGATGTCCTTCTGGCAGATGCCGTTAATCCCTGTGGTGAGCTG
CTGGCTGAACTACTTAACATACCCTTTCTGTACAGTCTCCGCTTCTCTGTTGGCTACACA
GTTGAGAAGAATGGTGGAGGATTTCTGTTCCCTCCTTCCTATGTACCTGTTGTTATGTCA
GAATTAAGTGATCAAATGATTTTCATGGAGAGGATAAAAAATATGATATATATGCTTTAT
TTTGACTTTTGGTTTCAAGCATATGATCTGAAGAAGTGGGACCAGTTTTATAGTGAAGTT
CTAGGAAGACCCACTACATTATTTGAGACAATGGGGAAAGCTGAAATGTGGCTCATTCGA
ACCTATTGGGATTTTGAATTTCCTCGCCCATTCTTACCAAATGTTGATTTTGTTGGAGGA
CTTCACTGTAAACCAGCCAAACCCTTGCCTAAGGAAATGGAAGAGTTTGTGCAGAGCTCT
GGAGAAAATGGTATTGTGGTGTTTTCTCTGGGGTCGATGATCAGTAACATGTCAGAAGAA
AGTGCCAACATGATTGCATCAGCCCTTGCCCAGATCCCACAAAAGGTTCTATGGAGATTT
GATGGCAAGAAGCCAAATACTTTAGGTTCCAATACTCGACTGTATAAGTGGTTACCCCAG
AATGACCTTCTTGGTCATCCCAAAACCAAAGCTTTTATAACTCATGGTGGAACCAATGGC
ATCTATGAGGCGATCTACCATGGGATCCCTATGGTGGGCATTCCCTTGTTTGCGGATCAA
CATGATAACATTGCTCACATGAAAGCCAAGGGAGCAGCCCTCAGTGTGGACATCAGGACC
ATGTCAAGTAGAGATTTGCTCAATGCATTGAAGTCAGTCATTAATGACCCTATCTATAAA
GAGAATATCATGAAATTATCAAGAATTCATCATGATCAACCGGTGAAGCCCCTGGATCGA
GCAGTCTTCTGGATTGAGTTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTCGCA
GCCCACAACCTCACCTGGATCCAGTACCACTCTTTGGATGTGATAGCATTCCTGCTGGCC
TGCGTGGCAACTATGATATTTATGATCACAAAATGTTGCCTGTTTTGTTTCCGAAAGCTT
GCCAAAACAGGAAAGAAGAAGAAAAGGGATTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
U59209

# Metabolic_Enzyme_4_Chromosome_Location:
Not Available

# Metabolic_Enzyme_4_Locus:
Not Available

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
8798464; 9364925

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5716

# Metabolic_Enzyme_5_Name:
Peroxisomal multifunctional enzyme type 2

# Metabolic_Enzyme_5_Synonyms:
MFE-2; D-bifunctional protein; DBP; 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-3-hydroxyacyl-CoA dehydratase; 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; 3- hydroxyacyl-CoA dehydrogenase

# Metabolic_Enzyme_5_Gene_Name:
HSD17B4

# Metabolic_Enzyme_5_Protein_Sequence:
>Peroxisomal multifunctional enzyme type 2
MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVE
EIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIH
RVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAI
EGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVG
AGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLS
KIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKD
LKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRA
GKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKV
AVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFS
ARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISN
AYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNI
GAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNI
MLSQKLQMILKDYAKL

# Metabolic_Enzyme_5_Number_of_Residues:
736

# Metabolic_Enzyme_5_Molecular_Weight:
79687

# Metabolic_Enzyme_5_Theoretical_pI:
9.21

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  binding
Function:  steroid binding
Function:  sterol carrier activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids

# Metabolic_Enzyme_5_Pathway:
map00062  Fatty acid biosynthesis (path 2);
 map00071  Fatty acid metabolism;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00380  Tryptophan metabolism;
 map00632  Benzoate degradation via CoA ligation;
 map00650  Butanoate metabolism;
 map00930  Caprolactam degradation

# Metabolic_Enzyme_5_Reaction:
(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00106:adh_short;
PF01575:MaoC_dehydratas;
PF02036:SCP2

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 4.2.1.107;EC 1.1.1.35

# Metabolic_Enzyme_5_GenBank_ID_Protein:
1050517

# Metabolic_Enzyme_5_SwissProt_ID:
DHB4_HUMAN (P51659)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
HSD17B4

# Metabolic_Enzyme_5_Geneatlas_id:
HSD17B4

# Metabolic_Enzyme_5_hgnc_id:
HGNC:5213

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_5_Gene_Sequence:
>2211 bp
ATGGGCTCACCGCTGAGGTTCGACGGGCGGGTGGTACTGGTCACCGGCGCGGGGGCAGGA
TTGGGCCGAGCCTATGCCCTGGCTTTTGCAGAAAGAGGAGCGTTAGTTGTTGTGAATGAT
TTGGGAGGGGACTTCAAAGGAGTTGGTAAAGGCTCCTTAGCTGCTGATAAGGTTGTTGAA
GAAATAAGAAGGAGAGGTGGAAAAGCAGTGGCCAACTATGATTCAGTGGAAGAAGGAGAG
AAGGTTGTGAAGACAGCCCTGGATGCTTTTGGAAGAATAGATGTTGTGGTCAACAATGCT
GGAATTCTGAGGGATCGTTCCTTTGCTAGGATAAGTGATGAAGACTGGGATATAATCCAC
AGAGTTCATTTGCGGGGTTCATTCCAAGTGACACGGGCAGCATGGGAACACATGAAGAAA
CAGAAGTATGGAAGGATTATTATGACTTCATCAGCTTCAGGAATATATGGCAACTTTGGC
CAGGCCAATTATAGTGCTGCAAAGTTGGGTCTTCTGGGCCTTGCAAATTCTCTTGCAATT
GAAGGCAGGAAAAGCAACATTCATTGTAACACCATTGCTCCTAATGCGGGATCACGGATG
ACTCAGACAGTTATGCCTGAAGATCTTGTGGAAGCCCTGAAGCCAGAGTATGTGGCACCT
CTTGTCCTTTGGCTTTGTCACGAGAGTTGTGAGGAGAATGGTGGCTTGTTTGAGGTTGGA
GCAGGATGGATTGGAAAATTACGCTGGGAGCGGACTCTTGGAGCTATTGTAAGACAAAAG
AATCACCCAATGACTCCTGAGGCAGTCAAGGCTAACTGGAAGAAGATCTGTGACTTTGAG
AATGCCAGCAAGCCTCAGAGTATCCAAGAATCAACTGGCAGTATAATTGAAGTTCTGAGT
AAAATAGATTCAGAAGGAGGAGTTTCAGCAAATCATACTAGTCGTGCAACGTCTACAGCA
ACATCAGGATTTGCTGGAGCTATTGGCCAGAAACTCCCTCCATTTTCTTATGCTTATACG
GAACTGGAAGCTATTATGTATGCCCTTGGAGTGGGAGCGTCAATCAAGGATCCAAAAGAT
TTGAAATTTATTTATGAAGGAAGTTCTGATTTCTCCTGTTTGCCCACCTTCGGAGTTATC
ATAGGTCAGAAATCTATGATGGGTGGAGGATTAGCAGAAATTCCTGGACTTTCAATCAAC
TTTGCAAAGGTTCTTCATGGAGAGCAGTACTTAGAGTTATATAAACCACTTCCCAGAGCA
GGAAAATTAAAATGTGAAGCAGTTGTTGCTGATGTCCTAGATAAAGGATCCGGTGTAGTG
ATTATTATGGATGTCTATTCTTATTCTGAGAAGGAACTTATATGCCACAATCAGTTCTCT
CTCTTTCTTGTTGGCTCTGGAGGCTTTGGTGGAAAACGGACATCAGACAAAGTCAAGGTA
GCTGTAGCCATACCTAATAGACCTCCTGATGCTGTACTTACAGATACCACCTCTCTTAAT
CAGGCTGCTTTGTACCGCCTCAGTGGAGACTGGAATCCCTTACACATTGATCCTAACTTT
GCTAGTCTAGCAGGTTTTGACAAGCCCATATTACATGGATTATGTACATTTGGATTTTCT
GCCAGGCGTGTGTTACAGCAGTTTGCAGATAATGATGTGTCAAGATTCAAGGCAATTAAG
GCTCGTTTTGCAAAACCAGTATATCCAGGACAAACTCTACAAACTGAGATGTGGAAGGAA
GGAAACAGAATTCATTTTCAAACCAAGGTCCAAGAAACTGGAGACATTGTCATTTCAAAT
GCATATGTGGATCTTGCACCAACATCTGGTACTTCAGCTAAGACACCCTCTGAGGGCGGG
AAGCTTCAGAGTACCTTTGTATTTGAGGAAATAGGACGCCGCCTAAAGGATATTGGGCCT
GAGGTGGTGAAGAAAGTAAATGCTGTATTTGAGTGGCATATAACCAAAGGCGGAAATATT
GGGGCTAAGTGGACTATTGACCTGAAAAGTGGTTCTGGAAAAGTGTACCAAGGCCCTGCA
AAAGGTGCTGCTGATACAACAATCATACTTTCAGATGAAGATTTCATGGAGGTGGTCCTG
GGCAAGCTTGACCCTCAGAAGGCATTCTTTAGTGGCAGGCTGAAGGCCAGAGGGAACATC
ATGCTGAGCCAGAAACTTCAGATGATTCTTAAAGACTACGCCAAGCTCTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X87176

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_5_Locus:
5q21

# Metabolic_Enzyme_5_SNPs:
rs25640; rs1143650; rs28943589; rs28943594; rs28943592; rs11539471; rs11205; rs28943591; rs28943590; rs28943588; rs2560722; rs12714; rs28943596; rs28943595; rs35293303; rs34753910; rs34353289; rs34604765; rs35520682; rs35233505; rs34381335; rs32659; rs382719; rs32651; rs2678091; rs26181; rs2451816; rs2678070; rs2459726; rs2636962; rs2546210; rs2636968; rs257970; rs1490756; rs2636961; rs2678074; rs10078097; rs26184; rs32665; rs11241506; rs2636964; rs2945327; rs10036783; rs463513; rs161857; rs422297; rs10064000; rs2259347; rs7714121; rs2287712; rs450118; rs257972; rs457106; rs11241507; rs32662; rs439954; rs7716785; rs2560723; rs455949; rs39970; rs161852; rs11957255; rs7706359; rs3797364; rs2652698; rs257973; rs257976; rs3797360; rs11748530; rs12189265; rs12655113; rs174008; rs32661; rs33950298; rs3756512; rs3850200; rs39971; rs32664; rs11746780; rs28590215; rs11749784; rs11949608; rs460274; rs3797368; rs10478424; rs6895345; rs32666; rs426899; rs17145473; rs2636965; rs3797372; rs257971; rs257969; rs2678077; rs6894991; rs3822527; rs150938; rs3797371; rs10041122; rs257985; rs257978; rs9327101; rs2404780; rs33926345; rs3797367; rs7708761; rs10051019; rs7723390; rs12653056; rs3797363; rs491526; rs9885031; rs2678076; rs17453681; rs6897978; rs11952687; rs2678067; rs12658566; rs17145475; rs17145464; rs10069875; rs17388769; rs2546209; rs28943593; rs11748477; rs442923; rs11744058; rs12653702; rs2257900; rs11949545; rs27938; rs6898518; rs6881294; rs528723; rs35509376; rs10440770; rs3756513; rs3850201; rs34072936; rs1155777; rs11738162; rs2546206; rs2678093; rs257974; rs2257901; rs161856; rs36201182; rs34742029; rs17145476; rs2636966; rs257977; rs10061692; rs2075698; rs10057944; rs13361193; rs381703; rs3756510; rs35201279; rs2678092; rs34843661; rs366568; rs2455463; rs10057263; rs36085051; rs2884597; rs10072256; rs9885037; rs10477586; rs10478426; rs10042168; rs34154113; rs257980; rs3933553; rs10041785; rs34480380; rs2678083; rs34894277; rs2303003; rs34554885; rs10045066; rs2678069; rs17145459; rs10040115; rs32663; rs2678075; rs17145471; rs2459727; rs32650; rs460945; rs13360025; rs2678082; rs34787820; rs36121886; rs17145469; rs35312742; rs11950471; rs34061771; rs3797365; rs2636967; rs34414937; rs32649; rs34019509; rs10062410; rs11742193; rs35442141; rs26183; rs2451814; rs3822525; rs257983; rs10463469; rs3797362; rs35908640; rs10073818; rs10045177; rs161851; rs35164142; rs34769530; rs10064454; rs10059654; rs28943586; rs28943587; rs11739468; rs34915828; rs35929961; rs35255511; rs34277908; rs35695978; rs26180; rs34300615; rs35121430; rs11539469; rs35281104; rs34959311; rs34407657; rs35065909; rs11539472; rs35946650; rs154596; rs35416500; rs2678097; rs35150552; rs28771700; rs35717907; rs34077636; rs10069657; rs28488436; rs9327103; rs35972810; rs11441269; rs35331622; rs35370764; rs35118616; rs11423266; rs35557161; rs7702730; rs34241171; rs35764784; rs34076336; rs161855; rs183761; rs3839244; rs13170615; rs28448457; rs28558429; rs34117860; rs10057643; rs34290512; rs3797369; rs2678073; rs6149207; rs11408993; rs34741016; rs35892291; rs35235684; rs11449982; rs34025534; rs34230952; rs2546202; rs9327102; rs13436061; rs28762138; rs35193622; rs13152959; rs2636972; rs35815725; rs35103609; rs2678096; rs4026601; rs34403323; rs5870858; rs13173615; rs2451815; rs3839245; rs3905777; rs13164650; rs161853; rs35896589; rs34776349; rs2636960; rs2546207; rs4472288; rs34797263; rs28371777; rs13179390; rs12658127; rs35513863; rs32660; rs34379490; rs13436451; rs2678071; rs2884596; rs34840516; rs35002045; rs28863779; rs4895193; rs17453513; rs2678072; rs3044997; rs35932005; rs34387330; rs34583966; rs35182344; rs2678068; rs35548886; rs10066301; rs2546203; rs35441752; rs11429994; rs34254740; rs28792671; rs35783015; rs35423756; rs36201214; rs34680033; rs34085452; rs13172850; rs3912770; rs3902524; rs10524491; rs35988302; rs28673725; rs10478425; rs35917386; rs28504028; rs1298928; rs13436186; rs2636959; rs34853445; rs10053773; rs34532819; rs28588064; rs10601221; rs2560724; rs12518814; rs2678095; rs34752619; rs13165698; rs257984; rs34691264; rs35315796; rs35747045; rs34859617; rs33991989; rs4266437; rs36033978; rs3839246; rs35916235; rs34704044; rs35689326; rs33948978; rs28683657; rs257979; rs11423247; rs28447568; rs36012938; rs10066302; rs34132585; rs2546204; rs13356711; rs10434766; rs11959382; rs3951345; rs11435738; rs3797366; rs35833256; rs2678094; rs11438902; rs35335781; rs2546205; rs34941861; rs11949790; rs4084849; rs3907443; rs28667304; rs35246432; rs161854; rs28501075; rs33962138; rs33937106; rs34359926; rs35819200; rs11308278; rs2546208; rs257975; rs7707838; rs34544399; rs2431545; rs28660051; rs11390174; rs2546211; rs2546212; rs13187421; rs13171550; rs11418368; rs5870857; rs35382678; rs12187149; rs35756585; rs13170866; rs35839873; rs36201183; rs2884522; rs12659452; rs2258658; rs35578461; rs3839243; rs34405263; rs35685451; rs13357948; rs6149208; rs35030315; rs35615592; rs3797361; rs32648; rs34464568; rs17552003; rs34245726; rs34926907; rs34429844; rs34401184; rs34212912; rs34142650; rs35833497; rs35305966; rs34812774; rs35181403; rs35999064; rs34198983; rs10043526; rs11951660; rs11955089; rs11956487; rs11959643; rs11959717; rs13361084; rs1651227; rs1651228; rs17145477; rs2560718; rs2560719; rs2560720; rs2561494; rs2636970; rs32647; rs463098

# Metabolic_Enzyme_5_General_References:
7487879; 9089413; 9880674; 8902629; 11700068

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5741

# Metabolic_Enzyme_6_Name:
UDP-glucuronosyltransferase 1-7 precursor

# Metabolic_Enzyme_6_Synonyms:
UDP- glucuronosyltransferase 1A7; UDPGT; UGT1*7; UGT1-07; UGT1.7; UGT- 1G; UGT1G

# Metabolic_Enzyme_6_Gene_Name:
UGT1A7

# Metabolic_Enzyme_6_Protein_Sequence:
>UDPglucuronosyltransferase 17 precursor
MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLF
FSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEG
AQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_6_Number_of_Residues:
530

# Metabolic_Enzyme_6_Molecular_Weight:
59819

# Metabolic_Enzyme_6_Theoretical_pI:
7.85

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_6_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_6_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_6_Signals:
1-25

# Metabolic_Enzyme_6_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_6_GenBank_ID_Protein:
2039360

# Metabolic_Enzyme_6_SwissProt_ID:
UD17_HUMAN (Q9HAW7)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
UGT1A7

# Metabolic_Enzyme_6_Geneatlas_id:
UGT1A7

# Metabolic_Enzyme_6_hgnc_id:
HGNC:12539

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Microsome

# Metabolic_Enzyme_6_Gene_Sequence:
>1593 bp
ATGGCTCGTGCAGGGTGGACTGGCCTCCTTCCCCTATATGTGTGTCTACTGCTGACCTGT
GGCTTTGCCAAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGCCACTGGTTCACC
ATGCAGTCGGTGGTGGAGAAACTCATCCTCAGGGGGCATGAGGTGGTCGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGGAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCA
TACACTCTGGAGGATCAGGACCGGGAGTTCATGGTTTTTGCCGATGCTCGCTGGACGGCA
CCATTGCGAAGTGCATTTTCTCTATTAACAAGTTCATCCAATGGTATTTTTGACTTATTT
TTTTCAAATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGT
TGTTTTGATGCAGTGTTTCTCGATCCTTTTGATGCCTGTGGCTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCGCCAGGGGAATATTTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGACTTCTCTTAGGGTTCTCAGACGCC
ATGACTTTCAAGGAGAGAGTATGGAACCACATCATGCACTTGGAGGAACATTTATTTTGC
CCCTATTTTTTCAAAAATGTCTTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACTGACTTTGTTTTGGAG
TATCCCAAACCCGTGATGCCCAATATGATCTTCATTGGTGGTATCAACTGTCATCAGGGA
AAGCCAGTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGCTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTTCAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
U89507

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_6_Locus:
2q37

# Metabolic_Enzyme_6_SNPs:
Not Available

# Metabolic_Enzyme_6_General_References:
9271343; 11434514; 11037804

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5727

# Metabolic_Enzyme_7_Name:
UDP-glucuronosyltransferase 1-8 precursor

# Metabolic_Enzyme_7_Synonyms:
UDP- glucuronosyltransferase 1A8; UDPGT; UGT1*8; UGT1-08; UGT1.8; UGT- 1H; UGT1H

# Metabolic_Enzyme_7_Gene_Name:
UGT1A8

# Metabolic_Enzyme_7_Protein_Sequence:
>UDPglucuronosyltransferase 18 precursor
MARTGWTSPIPLCVSLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLGKSLNCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLF
FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDACGLIVAKYFSLPSVVFARGIACHYLEEG
AQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLFCQYFSKNALEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_7_Number_of_Residues:
530

# Metabolic_Enzyme_7_Molecular_Weight:
59742

# Metabolic_Enzyme_7_Theoretical_pI:
7.73

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_7_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_7_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_7_Signals:
1-25

# Metabolic_Enzyme_7_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_7_GenBank_ID_Protein:
2613044

# Metabolic_Enzyme_7_SwissProt_ID:
UD18_HUMAN (Q9HAW9)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
UGT1A8

# Metabolic_Enzyme_7_Geneatlas_id:
UGT1A8

# Metabolic_Enzyme_7_hgnc_id:
HGNC:12540

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Microsome

# Metabolic_Enzyme_7_Gene_Sequence:
>1593 bp
ATGGCTCGCACAGGGTGGACCAGCCCCATTCCCCTATGTGTTTCTCTGCTGCTGACCTGT
GGCTTTGCTGAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGTCACTGGTTCACC
ATGCAGTCGGTGGTGGAGAAACTTATCCTCAGGGGGCATGAGGTGGTTGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGGAAAATCACTGAATTGCACAGTGAAGACTTACTCAACCTCA
TACACTCTGGAGGATCTGGACCGGGAATTCATGGATTTCGCCGATGCTCAATGGAAAGCA
CAAGTACGAAGTTTGTTTTCTCTATTTCTGAGTTCATCCAATGGTTTTTTTAACTTATTT
TTTTCGCATTGCAGGAGTTTGTTTAATGACCGAAGATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCGGTGTTTCTTGATCCTTTTGATGCCTGTGCGTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCGCCAGGGGAATAGGTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGAATTCTCTTAGGGTTCTCAGATGCC
ATGGCTTTCAAGGAGAGAGTACGGAACCACATCTTGCACTTGGAGGAACATTTATTTTGC
CAGTATTTTTCCAAAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACACCTGTCACA
GCATATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACAGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAATATGATCTTCATTGGTGGTATCAACTGCCATCAGGGA
AAGCCATTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AF030310

# Metabolic_Enzyme_7_Chromosome_Location:
Not Available

# Metabolic_Enzyme_7_Locus:
Not Available

# Metabolic_Enzyme_7_SNPs:
Not Available

# Metabolic_Enzyme_7_General_References:
9535849; 11434514; 12042666

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5582

# Metabolic_Enzyme_8_Name:
Estrogen sulfotransferase

# Metabolic_Enzyme_8_Synonyms:
Sulfotransferase, estrogen- preferring; EST-1

# Metabolic_Enzyme_8_Gene_Name:
SULT1E1

# Metabolic_Enzyme_8_Protein_Sequence:
>Estrogen sulfotransferase
MNSELDYYEKFEEVHGILMYKDFVKYWDNVEAFQARPDDLVIATYPKSGTTWVSEIVYMI
YKEGDVEKCKEDVIFNRIPFLECRKENLMNGVKQLDEMNSPRIVKTHLPPELLPASFWEK
DCKIIYLCRNAKDVAVSFYYFFLMVAGHPNPGSFPEFVEKFMQGQVPYGSWYKHVKSWWE
KGKSPRVLFLFYEDLKEDIRKEVIKLIHFLERKPSEELVDRIIHHTSFQEMKNNPSTNYT
TLPDEIMNQKLSPFMRKGITGDWKNHFTVALNEKFDKHYEQQMKESTLKFRTEI

# Metabolic_Enzyme_8_Number_of_Residues:
294

# Metabolic_Enzyme_8_Molecular_Weight:
35127

# Metabolic_Enzyme_8_Theoretical_pI:
6.61

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
May control the level of the estrogen receptor by sulfurylating free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated

# Metabolic_Enzyme_8_Pathway:
map00150  Androgen and estrogen metabolism;
 map00920  Sulfur metabolism

# Metabolic_Enzyme_8_Reaction:
3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.8.2.4

# Metabolic_Enzyme_8_GenBank_ID_Protein:
488283

# Metabolic_Enzyme_8_SwissProt_ID:
ST1E1_HUMAN (P49888)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
SULT1E1

# Metabolic_Enzyme_8_Geneatlas_id:
SULT1E1

# Metabolic_Enzyme_8_hgnc_id:
HGNC:11377

# Metabolic_Enzyme_8_PDB_ID:
1G3M

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_8_Gene_Sequence:
>885 bp
ATGAATTCTGAACTTGACTATTATGAAAAGTTTGAAGAAGTCCATGGGATTCTAATGTAT
AAAGATTTTGTCAAATATTGGGATAATGTGGAAGCGTTCCAGGCAAGACCAGATGATCTT
GTCATTGCCACCTACCCTAAATCTGGTACAACCTGGGTTAGTGAAATTGTGTATATGATC
TATAAAGAGGGTGATGTGGAAAAGTGCAAAGAAGATGTAATTTTTAATCGAATACCTTTC
CTGGAATGCAGAAAAGAAAACCTCATGAATGGAGTAAAACAATTAGATGAGATGAATTCT
CCTAGAATTGTGAAGACTCATTTGCCACCTGAACTTCTTCCTGCCTCATTTTGGGAAAAG
GATTGTAAGATAATCTATCTTTGCCGGAATGCAAAGGATGTGGCTGTTTCCTTTTATTAT
TTCTTTCTAATGGTGGCTGGTCATCCAAATCCTGGATCCTTTCCAGAGTTTGTGGAGAAA
TTCATGCAAGGACAGGTTCCTTATGGTTCCTGGTATAAACATGTAAAATCTTGGTGGGAA
AAGGGAAAGAGTCCACGTGTACTATTTCTTTTCTACGAAGACCTGAAAGAGGATATCAGA
AAAGAGGTGATAAAATTGATACATTTCCTGGAAAGGAAGCCATCAGAGGAGCTTGTGGAC
AGGATTATACATCATACTTCGTTCCAAGAGATGAAGAACAATCCATCCACAAATTACACA
ACACTGCCAGACGAAATTATGAACCAGAAATTGTCGCCCTTCATGAGAAAGGGAATTACA
GGAGACTGGAAAAATCACTTTACAGTAGCCCTGAATGAAAAATTTGATAAACATTATGAG
CAGCAAATGAAGGAATCTACACTGAAGTTTCGAACTGAGATCTAA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
U08098

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_8_Locus:
4q13.1

# Metabolic_Enzyme_8_SNPs:
rs11569705; rs11569708; rs2091597; rs3822172; rs1881668; rs1534672; rs11569706; rs3822173; rs11573744; rs4149528; rs3775770; rs3736599; rs4149530; rs3775767; rs11573750; rs3775768; rs11573742; rs4149536; rs11573746; rs11573801; rs4149527; rs11573741; rs1220704; rs3775778; rs4149532; rs4694036; rs6600802; rs11249468; rs4149535; rs1220702; rs2331821; rs11249469; rs3775779; rs3775775; rs1852802; rs4149533; rs3775774; rs11573763; rs11249465; rs4149534; rs1852801; rs3775777; rs1220703; rs1220724; rs4149531; rs11573764; rs10019305; rs11573783; rs11249466; rs11249467; rs3842002; rs3775773; rs1220716; rs11573757; rs11249470; rs3775776; rs11573766; rs11573776; rs11573768; rs11573770; rs11573791; rs11573759; rs11573765; rs7674669; rs11573792; rs11573779; rs1238574; rs11573780; rs11573786; rs11573789; rs4235086; rs11573784; rs11573769; rs11573787; rs11573793; rs11573760; rs11573777; rs11573795; rs11573767; rs11573790; rs1220715; rs11573778; rs11573758; rs1220725; rs11573734; rs11573736; rs11573738; rs11573739; rs1231464; rs11573737; rs4149525; rs4149524; rs11573733; rs17852473; rs11573800; rs11573745; rs35543098; rs11573743; rs34879420; rs11573748; rs11549299; rs11573747; rs11573751; rs11573796; rs11573794; rs34062984; rs34196771; rs11573788; rs11573772; rs3775771; rs11573797; rs17147782; rs11573782; rs28782803; rs11464421; rs35088812; rs34026004; rs11573775; rs11573755; rs34559810; rs13113890; rs35832077; rs34678375; rs11573756; rs35965531; rs11573798; rs3077575; rs11573771; rs11573785; rs2055533; rs34408656; rs13113889; rs17147780; rs10535870; rs34468028; rs34033191; rs11573761; rs11573774; rs11573799; rs11573781; rs11573762; rs34924616; rs11573773; rs35426695; rs3822174; rs3775772; rs28489656; rs11573740; rs28727889; rs4149526; rs11573735; rs10213450; rs10213454; rs11249464; rs11569707; rs11569709; rs11569711; rs11569712; rs11569713; rs11569714; rs1220726; rs1237749; rs12499679; rs13102618; rs13115660; rs1354362; rs1503726; rs1503727; rs1529039; rs1529040; rs1590128; rs17147766; rs17147770; rs17684166; rs1827565; rs1910465; rs34139453; rs34547148; rs35942703; rs4149529; rs4334813; rs4616827; rs6600803; rs6818146; rs6845469; rs7655478

# Metabolic_Enzyme_8_General_References:
8185618; 8530066; 7779757; 10541560

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5733

# Metabolic_Enzyme_9_Name:
UDP-glucuronosyltransferase 1-5 precursor

# Metabolic_Enzyme_9_Synonyms:
UDP- glucuronosyltransferase 1A5; UDPGT; UGT1*5; UGT1-05; UGT1.5; UGT- 1E; UGT1E

# Metabolic_Enzyme_9_Gene_Name:
UGT1A5

# Metabolic_Enzyme_9_Protein_Sequence:
>UDPglucuronosyltransferase 15 precursor
MATGLQVPLPQLATGLLLLLSVQPWAESGKVLVVPTDGSHWLSMREALRDLHARGHQVVV
LTLEVNMYIKEENFFTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNM
SLIIHRSCVELLHNEALIRHLHATSFDVVLTDPFHLCAAVLAKYLSIPAVFFLRNIPCDL
DFKGTQCPNPSSYIPRLLTTNSDHMTFLQRVKNMLYPLALSYLCHAVSAPYASLASELFQ
REVSVVDLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_9_Number_of_Residues:
534

# Metabolic_Enzyme_9_Molecular_Weight:
60072

# Metabolic_Enzyme_9_Theoretical_pI:
8.14

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_9_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_9_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_9_Signals:
1-28

# Metabolic_Enzyme_9_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_9_GenBank_ID_Protein:
340139

# Metabolic_Enzyme_9_SwissProt_ID:
UD15_HUMAN (P35504)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
UGT1A5

# Metabolic_Enzyme_9_Geneatlas_id:
UGT1A5

# Metabolic_Enzyme_9_hgnc_id:
HGNC:12537

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Microsome

# Metabolic_Enzyme_9_Gene_Sequence:
>867 bp
ATGGCCACAGGACTCCAGGTTCCCCTGCCGCAGCTGGCCACAGGACTGCTGCTTCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGGAAGGTGCTGGTGGTGCCCACTGATGGCAGCCAC
TGGCTCAGCATGCGGGAGGCCTTGCGGGACCTCCATGCGAGAGGCCACCAGGTGGTGGTC
CTCACCCTGGAGGTGAATATGTACATCAAAGAAGAGAACTTTTTCACCCTGACAACGTAT
GCCATTTCATGGACCCAGGACGAATTTGATCGCCTTTTGCTGGGTCACACTCAATCGTTC
TTTGAAACAGAACATCTTCTGATGAAATTTTCTAGAAGAATGGCAATTATGAACAATATG
TCTTTGATCATACATAGGTCTTGTGTGGAGCTACTGCATAATGAGGCCCTGATCAGGCAC
CTGCATGCTACTTCCTTTGATGTGGTTCTAACAGACCCCTTTCACCTCTGCGCGGCGGTG
CTGGCTAAGTACCTGTCGATTCCTGCTGTGTTTTTCTTGAGGAACATTCCATGTGATTTA
GACTTTAAGGGCACACAGTGTCCAAACCCTTCCTCCTATATTCCTAGATTACTAACGACC
AATTCAGACCACATGACATTCCTGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACCTTTGCCATGCTGTTTCTGCTCCTTATGCAAGCCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATCTTGTCAGCCATGCATCTGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGATTACCCCAGGCCGATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACGGGAAGCCACTATCTCAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
M84129

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_9_Locus:
2q37

# Metabolic_Enzyme_9_SNPs:
Not Available

# Metabolic_Enzyme_9_General_References:
1339448; 11434514

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5721

# Metabolic_Enzyme_10_Name:
UDP-glucuronosyltransferase 2B7 precursor

# Metabolic_Enzyme_10_Synonyms:
UDPGT; 3,4- catechol estrogen specific; UDPGTh-2

# Metabolic_Enzyme_10_Gene_Name:
UGT2B7

# Metabolic_Enzyme_10_Protein_Sequence:
>UDPglucuronosyltransferase 2B7 precursor
MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSA
SILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFG
DITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTF
EKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVL
GRPTTLSETMGKADVWLIRNSWNFQFPHPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSG
ENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTM
SSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND

# Metabolic_Enzyme_10_Number_of_Residues:
529

# Metabolic_Enzyme_10_Molecular_Weight:
60695

# Metabolic_Enzyme_10_Theoretical_pI:
8.45

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites

# Metabolic_Enzyme_10_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_10_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_10_Signals:
1-23

# Metabolic_Enzyme_10_Transmembrane_Regions:
493-509

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_10_GenBank_ID_Protein:
340080

# Metabolic_Enzyme_10_SwissProt_ID:
UDB7_HUMAN (P16662)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
UGT2B7

# Metabolic_Enzyme_10_Geneatlas_id:
UGT2B7

# Metabolic_Enzyme_10_hgnc_id:
HGNC:12554

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Microsome

# Metabolic_Enzyme_10_Gene_Sequence:
>1590 bp
ATGTCTGTGAAATGGACTTCAGTAATTTTGCTAATACAACTGAGCTTTTGCTTTAGCTCT
GGGAATTGTGGAAAGGTGCTGGTGTGGGCAGCAGAATACAGCCATTGGATGAATATAAAG
ACAATCCTGGATGAGCTTATTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAACAACTCATCCGCTCTTAAAATTGAAATTTATCCCACATCT
TTAACTAAAACTGAGTTGGAGAATTTCATCATGCAACAGATTAAGAGATGGTCAGACCTT
CCAAAAGATACATTTTGGTTATATTTTTCACAAGTACAGGAAATCATGTCAATATTTGGT
GACATAACTAGAAAGTTCTGTAAAGATGTAGTTTCAAATAAGAAATTTATGAAAAAAGTA
CAAGAGTCAAGATTTGACGTCATTTTTGCAGATGCTATTTTTCCCTGTAGTGAGCTGCTG
GCTGAGCTATTTAACATACCCTTTGTGTACAGTCTCAGCTTCTCTCCTGGCTACACTTTT
GAAAAGCATAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAGAA
TTAACTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTACTTT
GACTTTTGGTTCGAAATATTTGACATGAAGAAGTGGGATCAGTTTTATAGTGAAGTTCTA
GGAAGACCCACTACGTTATCTGAGACAATGGGGAAAGCTGACGTATGGCTTATTCGAAAC
TCCTGGAATTTTCAGTTTCCTCATCCACTCTTACCAAATGTTGATTTTGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTGCCTAAGGAAATGGAAGACTTTGTACAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGG
GCCAACGTAATTGCATCAGCCCTGGCCCAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATACCTTAGGTCTCAATACTCGGCTGTATAAGTGGATACCCCAGAAT
GACCTTCTAGGTCATCCAAAGACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TACGAGGCAATCTACCATGGGATCCCTATGGTGGGGATTCCATTGTTTGCCGATCAACCT
GATAACATTGCTCACATGAAGGCCAGGGGAGCAGCTGTTAGAGTGGACTTCAACACAATG
TCGAGTACAGACTTGCTGAATGCATTGAAGAGAGTAATTAATGATCCTTCATATAAAGAG
AATGTTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCTAAACACCTTCGGGTTGCAGCC
CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGTCTGT
GTGGCAACTGTGATATTTATCGTCACAAAATGTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGCAAAGAAGGGAAAAAATGATTAG

# Metabolic_Enzyme_10_GenBank_ID_Gene:
J05428

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_10_Locus:
4q13

# Metabolic_Enzyme_10_SNPs:
rs7439366; rs12233719; rs35590824; rs7438284; rs4348159; rs4292394; rs28365062; rs5013211; rs7686056; rs6600884; rs7441750; rs7439152; rs12513195; rs4293848; rs3924192; rs7442453; rs7698846; rs7678656; rs12506962; rs7441774; rs6600888; rs6858558; rs6600885; rs6600891; rs7375178; rs7435335; rs6600890; rs6600887; rs7438244; rs4521414; rs6600889; rs12647682; rs7434332; rs12508257; rs4694628; rs6600886; rs4314347; rs12647681; rs7439326; rs7698645; rs12512526; rs10028494; rs9995928; rs3924194; rs6600892; rs4364327; rs3924193; rs12642938; rs4337789; rs7679184; rs12648462; rs10050146; rs4257713; rs4588522; rs4356975; rs7693957; rs7658752; rs4314345; rs7438942; rs4351080; rs4541594; rs10006452; rs6851533; rs6600880; rs7438135; rs11940316; rs6600879; rs7668282; rs7668258; rs4538548; rs6600883; rs6600893; rs7662029; rs4455491; rs11940220; rs4554144; rs5859163; rs34620993; rs34851008; rs34308305; rs34661811; rs35327868; rs35893826; rs10022440; rs13136922; rs34407256; rs35452834; rs34095769; rs5859161; rs34241812; rs34302283; rs34386959; rs35475910; rs34561399; rs28675300; rs34556519; rs28673873; rs35185848; rs28539948; rs34571475; rs34318523; rs35402056; rs5859162; rs34182209; rs4694177; rs28375964; rs35605246; rs11302069; rs10008743; rs5859160; rs4356974; rs34630750; rs7437605; rs6819882; rs34590280; rs11249527; rs11249528; rs12506592; rs13118991; rs13135225; rs28365063; rs4274916; rs4358465; rs4434330; rs4535394; rs4694169; rs6422323; rs6422324; rs6600876; rs6843382; rs7437174; rs7657423; rs7676472

# Metabolic_Enzyme_10_General_References:
2159463; 11186130

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5687

# Metabolic_Enzyme_11_Name:
UDP-glucuronosyltransferase 2B28 precursor

# Metabolic_Enzyme_11_Synonyms:
UDPGT

# Metabolic_Enzyme_11_Gene_Name:
UGT2B28

# Metabolic_Enzyme_11_Protein_Sequence:
>UDPglucuronosyltransferase 2B28 precursor
MALKWTSVLLLIHLGCYFSSGSCGKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDIQKDSFWLYFSQEQEILWEFH
DIFRNFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTI
ERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWFQMCDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTM
SSTDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAA
RDLTWFQYHSLDVIGFLLACVATVIFVVTKFCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_11_Number_of_Residues:
529

# Metabolic_Enzyme_11_Molecular_Weight:
60907

# Metabolic_Enzyme_11_Theoretical_pI:
8.80

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta- diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active

# Metabolic_Enzyme_11_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_11_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_11_Signals:
1-24

# Metabolic_Enzyme_11_Transmembrane_Regions:
495-517

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_11_GenBank_ID_Protein:
13603476

# Metabolic_Enzyme_11_SwissProt_ID:
UDB28_HUMAN (Q9BY64)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
UGT2B28

# Metabolic_Enzyme_11_Geneatlas_id:
UGT2B28

# Metabolic_Enzyme_11_hgnc_id:
HGNC:13479

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Microsome

# Metabolic_Enzyme_11_Gene_Sequence:
>1590 bp
ATGGCTCTGAAGTGGACTTCAGTTCTTCTGCTGATACATCTCGGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGACCGGTGAATACAGCCATTGGATGAATATGAAG
ACAATCCTGAAAGAGCTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAATGACGCATTCACTCTTAAACTCGAAGTTTATCCTACATCT
TTAACTAAAACTGAATTTGAGAATATCATCATGCAACAGGTTAAGAGATGGTCAGACATT
CAAAAAGATAGCTTTTGGTTATATTTTTCACAAGAACAAGAAATCCTGTGGGAATTTCAT
GACATATTTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAAGTTATGAAAAAACTA
CAAGAGTCAAGATTTGACATCATTTTTGCAGATGCTTTTTTTCCTTGTGGTGAGCTGCTG
GCTGCGCTACTTAACATACCGTTTGTGTACAGTCTCTGCTTCACTCCTGGCTACACAATT
GAAAGGCACAGTGGAGGACTGATTTTCCCTCCTTCCTACATACCTGTTGTTATGTCAAAA
TTAAGTGATCAAATGACTTTCATGGAGAGGGTAAAAAACATGATCTATGTGCTTTATTTT
GACTTTTGGTTCCAAATGTGTGATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTA
GGAAGACCCACTACCTTATTTGAGACAATGGGGAAAGCTGACATATGGCTTATGCGAAAC
TCCTGGAGTTTTCAATTTCCTCATCCATTCTTACCAAACATTGATTTTGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAATTTGTACAGAGCTCTGGT
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAGTGATAAGTAACATGACAGCAGAAAGG
GCCAACGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATGCCTTAGGTCTCAATACTCGGCTGTATAAGTGGATACCCCAGAAT
GACCTTCTAGGTCTTCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATGAGGCAATCTACCATGGGATCCCTATGGTAGGCATTCCATTGTTTTGGGATCAACCT
GATAACATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGACTGGACTTCCACACAATG
TCGAGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTCATATAAAGAG
AATGTTATGAAATTATCAATAATTCAACATGATCAACCAGTAAAGCCCCTGCATCGAGCA
GTCTTCTGGATTGAATTTGTGATGTGCCACAAAGGAGCCAAACACCTTCGAGTTGCAGCC
CGTGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTTCTGCTGGCCTGT
GTGGCAACTGTGATATTTGTCGTCACAAAGTTTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGGGAAGAAGGGAAAAAGAGATTAG

# Metabolic_Enzyme_11_GenBank_ID_Gene:
AF177272

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_11_Locus:
4q13.2

# Metabolic_Enzyme_11_SNPs:
rs4235127; rs4260604; rs4386668; rs11726210; rs10002503; rs4235126; rs3901337; rs4260603; rs10008843; rs4694712; rs4301173; rs4694711; rs2132039; rs9997242; rs4260602; rs4235125; rs4694713; rs7686786; rs10000077; rs7437560; rs7681187; rs10023367; rs7657406; rs41292949; rs6843900; rs6828191; rs41292951; rs10013145; rs7689398; rs41292341; rs13139691; rs13138824; rs4569811; rs6827801; rs34313836; rs5004177; rs28376412; rs13108235; rs5004180; rs4295327; rs4568294; rs4450998; rs33966513; rs5004176; rs35191928; rs13107778; rs4345242; rs34549399; rs4495113; rs5004183; rs41292945; rs41292947; rs35437714; rs35925451; rs13146763; rs28447469; rs35059283; rs5004182; rs7435249; rs5004175; rs5859170; rs4515230; rs6840320; rs35572829; rs5004178; rs5004179; rs4597901; rs41292339; rs5004181; rs13116501; rs10011666; rs41292343; rs7657045; rs13124875; rs9991645; rs35680160; rs6600920

# Metabolic_Enzyme_11_General_References:
11300766

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5719

# Metabolic_Enzyme_12_Name:
UDP-glucuronosyltransferase 1-4 precursor

# Metabolic_Enzyme_12_Synonyms:
UDP- glucuronosyltransferase 1A4; UDPGT; UGT1*4; UGT1-04; UGT1.4; UGT- 1D; UGT1D; Bilirubin-specific UDPGT isozyme 2; HUG-BR2

# Metabolic_Enzyme_12_Gene_Name:
UGT1A4

# Metabolic_Enzyme_12_Protein_Sequence:
>UDPglucuronosyltransferase 14 precursor
MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVV
LTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNV
SLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDL
DFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQ
REVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_12_Number_of_Residues:
534

# Metabolic_Enzyme_12_Molecular_Weight:
60026

# Metabolic_Enzyme_12_Theoretical_pI:
8.68

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_12_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

# Metabolic_Enzyme_12_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_12_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_12_Signals:
1-28

# Metabolic_Enzyme_12_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_12_GenBank_ID_Protein:
340137

# Metabolic_Enzyme_12_SwissProt_ID:
UD14_HUMAN (P22310)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
UGT1A4

# Metabolic_Enzyme_12_Geneatlas_id:
UGT1A4

# Metabolic_Enzyme_12_hgnc_id:
HGNC:12536

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Microsome

# Metabolic_Enzyme_12_Gene_Sequence:
>867 bp
ATGGCCAGAGGACTCCAGGTTCCCCTGCCGCGGCTGGCCACAGGACTGCTGCTCCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCACTGATGGCAGCCCC
TGGCTCAGCATGCGGGAGGCCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCGGTGGTC
CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAAATTTTTCACCCTGACAGCCTAT
GCTGTTCCATGGACCCAGAAGGAATTTGATCGCGTTACGCTGGGCTACACTCAAGGGTTC
TTTGAAACAGAACATCTTCTGAAGAGATATTCTAGAAGTATGGCAATTATGAACAATGTA
TCTTTGGCCCTTCATAGGTGTTGTGTGGAGCTACTGCATAATGAGGCCCTGATCAGGCAC
CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGTGGGGCGGTG
CTGGCTAAGTACCTGTCGATTCCTGCTGTGTTTTTTTGGAGGTACATTCCATGTGACTTA
GACTTTAAGGGCACACAGTGTCCAAATCCTTCCTCCTATATTCCTAAGTTACTAACGACC
AATTCAGACCACATGACATTCCTGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACATTTGCCATACTTTTTCTGCCCCTTATGCAAGTCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATCTTGTCAGCTATGCATCCGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGACTACCCCAGGCCGATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACGGGAAGCCACTATCTCAG

# Metabolic_Enzyme_12_GenBank_ID_Gene:
M84128

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_12_Locus:
2q37

# Metabolic_Enzyme_12_SNPs:
Not Available

# Metabolic_Enzyme_12_General_References:
1898728; 1339448; 11434514; 1634050; 8280139; 8276413

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
6127

# Metabolic_Enzyme_13_Name:
Estradiol 17-beta-dehydrogenase 3

# Metabolic_Enzyme_13_Synonyms:
17-beta-HSD 3; Testicular 17-beta-hydroxysteroid dehydrogenase

# Metabolic_Enzyme_13_Gene_Name:
HSD17B3

# Metabolic_Enzyme_13_Protein_Sequence:
>Estradiol 17betadehydrogenase 3
MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGI
GKAYSFELAK
RGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEK
LAGLEIGILVNNVGMLPNLLP
SHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKG
LILNISSGIALFPWPLYSMYSASKAFVCAFSK
ALQEEYKAKEVIIQVLTPYAVSTAMTK
YLNTNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSL
IPAWAFYSGAFQRLLL
THYVAYLKLNTKVR

# Metabolic_Enzyme_13_Number_of_Residues:
310

# Metabolic_Enzyme_13_Molecular_Weight:
34516

# Metabolic_Enzyme_13_Theoretical_pI:
8.84

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Not Available

# Metabolic_Enzyme_13_Specific_Function:
Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH

# Metabolic_Enzyme_13_Pathway:
map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_13_Reaction:
estradiol-17beta + NAD(P)+ = estrone + NAD(P)H + H+

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_13_Signals:
1-24

# Metabolic_Enzyme_13_Transmembrane_Regions:
178-200; 269-291

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 1.1.1.62

# Metabolic_Enzyme_13_GenBank_ID_Protein:
531162

# Metabolic_Enzyme_13_SwissProt_ID:
DHB3_HUMAN (P37058)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
HSD17B3

# Metabolic_Enzyme_13_Geneatlas_id:
HSD17B3

# Metabolic_Enzyme_13_hgnc_id:
HGNC:5212

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Membrane

# Metabolic_Enzyme_13_Gene_Sequence:
>933 bp

ATGGGGGACGTCCTGGAACAGTTCTTCATCCTCACAGGGCTGCTGGTGTGCCTGGCCTG
CCTGGCGAAGT
GCGTGAGATTCTCCAGATGTGTTTTACTGAACTACTGGAAAGTTTTGC
CAAAGTCTTTCTTGCGGTCAAT
GGGACAGTGGGCAGTGATCACTGGAGCAGGCGATGGA
ATTGGGAAAGCGTACTCGTTCGAGCTAGCAAAA
CGTGGACTCAATGTTGTCCTTATTAG
CCGGACGCTGGAAAAACTAGAGGCCATTGCCACAGAGATCGAGC
GGACTACAGGGAGGA
GTGTGAAGATTATACAAGCAGATTTTACAAAAGATGACATCTACGAGCATATTAA
AGAA
AAACTTGCAGGCTTAGAAATTGGAATTTTAGTCAACAATGTCGGAATGCTTCCAAACCTT
CTCCCA
AGCCATTTCCTGAACGCACCGGATGAAATCCAGAGCCTCATCCATTGTAACAT
CACCTCCGTAGTCAAGA
TGACACAGCTAATTCTGAAACATATGGAATCAAGGCAGAAAG
GTCTCATCCTGAACATTTCTTCTGGGAT
AGCCCTGTTTCCTTGGCCTCTCTACTCCATG
TACTCAGCTTCCAAGGCGTTTGTGTGCGCATTTTCCAAG
GCCCTGCAAGAGGAATATAA
AGCAAAAGAAGTCATCATCCAGGTGCTGACCCCATATGCTGTCTCGACTG
CAATGACAA
AGTATCTAAATACAAATGTGATAACCAAGACTGCTGATGAGTTTGTCAAAGAGTCATTGA
A
TTATGTCACAATTGGAGGTGAAACCTGTGGCTGCCTTGCCCATGAAATCTTGGCGGGC
TTTCTGAGCCTG
ATCCCGGCCTGGGCCTTCTACAGCGGTGCCTTCCAAAGGCTGCTCCT
GACACACTATGTGGCATACCTGA
AGCTCAACACCAAGGTCAGGTAG

# Metabolic_Enzyme_13_GenBank_ID_Gene:
U05659

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_13_Locus:
9q22

# Metabolic_Enzyme_13_SNPs:
rs2066480; rs2066479; rs2066478; rs8190555; rs35189151; rs2224864; rs2066474; rs2066484; rs2066476; rs35024493; rs2026001; rs371119; rs408876; rs999269; rs912463; rs912464; rs375411; rs2147253; rs7039978; rs8190508; rs2476921; rs2476920; rs729390; rs7022250; rs280654; rs8190531; rs2066475; rs8190566; rs6479179; rs7863067; rs416699; rs2243595; rs1927882; rs370438; rs9299363; rs1119864; rs8190513; rs8190542; rs8190541; rs912461; rs8190554; rs2476923; rs441402; rs867807; rs280658; rs2066473; rs10820247; rs2066485; rs8190522; rs1983828; rs2479825; rs407179; rs8190568; rs10125001; rs7037932; rs8190534; rs7868919; rs913580; rs7029101; rs280663; rs8190529; rs166819; rs2476927; rs8190490; rs2066483; rs4401999; rs10739847; rs8190496; rs379734; rs2479821; rs1886260; rs10820208; rs2256618; rs8190504; rs2066487; rs2066477; rs10990258; rs8190535; rs2257157; rs392312; rs12552648; rs7043341; rs8190483; rs8190569; rs1807197; rs2479828; rs2147252; rs8190512; rs2476922; rs8190523; rs11788083; rs7022826; rs280662; rs2066482; rs1810711; rs8190530; rs1927883; rs8190536; rs8190557; rs7873481; rs8190560; rs8190505; rs2987356; rs394243; rs2066486; rs2253502; rs4551481; rs16910680; rs2479824; rs8190549; rs375944; rs2183009; rs11788785; rs2479822; rs8190540; rs8190498; rs12682944; rs8190515; rs280656; rs8190501; rs35056365; rs8190551; rs8190488; rs2479823; rs2066481; rs10820245; rs1225274; rs10990247; rs8190492; rs7042971; rs8190484; rs10820228; rs11789467; rs7859733; rs8190556; rs35688278; rs7040523; rs11791650; rs8190506; rs8190533; rs8190493; rs8190487; rs11789867; rs8190544; rs280665; rs912462; rs8190537; rs12552750; rs8190559; rs8190561; rs2181820; rs400851; rs10990255; rs35567655; rs8190489; rs12683472; rs10117181; rs10820205; rs12684447; rs35638259; rs8190527; rs8190495; rs8190552; rs16910690; rs2476925; rs10820243; rs8190525; rs8190570; rs280657; rs8190500; rs35537194; rs10820188; rs10990236; rs10990246; rs8190497; rs8190514; rs3925451; rs8190532; rs7043452; rs280655; rs6479186; rs12553488; rs10990251; rs8190550; rs4269659; rs2770143; rs10820220; rs8190485; rs10990202; rs8190562; rs16910694; rs13302476; rs34258388; rs8190518; rs8190539; rs35264203; rs6479221; rs35920604; rs1571399; rs280664; rs11791540; rs12686518; rs10990201; rs12005851; rs10990208; rs35010891; rs2987360; rs9409407; rs10820242; rs8190486; rs2476926; rs10733725; rs10820289; rs2026003; rs4743709; rs7029369; rs7872344; rs7048229; rs8190482; rs8190573; rs8190575; rs8190574; rs8190480; rs8190576; rs1324196; rs8190580; rs7848739; rs8190481; rs28932191; rs35907896; rs4743704; rs8190478; rs8190571; rs7848833; rs8190479; rs7024573; rs28932190; rs8190577; rs8190579; rs34862233; rs12003404; rs34268513; rs10524217; rs34020460; rs7357770; rs35605750; rs1753313; rs5899284; rs28393240; rs12345460; rs8190491; rs34712901; rs34749486; rs12377687; rs34607511; rs34252191; rs10990269; rs11324337; rs10684729; rs35463519; rs34835687; rs10990237; rs435265; rs8190546; rs13286372; rs11410872; rs10119272; rs34768651; rs35760395; rs8190565; rs10990350; rs13284535; rs34919185; rs8190511; rs7042315; rs12345464; rs10990203; rs13292483; rs5899282; rs9409053; rs12337479; rs34328277; rs34696429; rs10990349; rs10639612; rs2296211; rs13297204; rs12345498; rs12345462; rs34057561; rs10615794; rs8190545; rs28401600; rs2296210; rs11301816; rs10990320; rs34430175; rs7357765; rs8190510; rs2985282; rs12347921; rs35605782; rs13301464; rs13289967; rs8190519; rs10990146; rs34410351; rs11789590; rs35645593; rs12349596; rs35806560; rs28623339; rs36102384; rs2987357; rs4495556; rs7038184; rs28565462; rs35918093; rs10990348; rs11453214; rs8190517; rs9657644; rs10120717; rs11496626; rs34442358; rs10680950; rs34372619; rs1571400; rs11789582; rs2985281; rs8190548; rs35522080; rs8190538; rs34131940; rs10990306; rs10559450; rs9777382; rs34981993; rs35343617; rs36069609; rs10639457; rs12335993; rs8190547; rs10624364; rs8190502; rs11496541; rs10990254; rs7045594; rs35535710; rs35600106; rs3831056; rs34042448; rs8190543; rs34058347; rs11335254; rs34430203; rs8190499; rs35816882; rs34162871; rs10990356; rs34441335; rs35307721; rs35659617; rs13284833; rs35962525; rs35214327; rs11281254; rs4743685; rs11417524; rs35427805; rs36117803; rs5899285; rs13284819; rs34800961; rs35280549; rs35941200; rs8190509; rs34358443; rs8190521; rs2183010; rs34280228; rs34975803; rs34156466; rs34593569; rs36018805; rs8190558; rs7037679; rs36086036; rs1125964; rs8190563; rs10545828; rs4266767; rs35309344; rs172169; rs35526475; rs8190507; rs33914106; rs5899283; rs182207; rs12345184; rs12339274; rs28523601; rs7357803; rs1238256; rs8190526; rs8190503; rs7869083; rs35263931; rs7852386; rs8190516; rs12345535; rs8190567; rs10990147; rs8190564; rs11515574; rs34686124; rs8190553; rs10990352; rs8190494; rs34577755; rs34024715; rs35689970; rs12342506; rs28421370; rs34355657; rs34140038; rs10541572; rs12338600; rs34849790; rs34051033; rs34240849; rs7049076; rs34912237; rs8190578; rs35789085; rs35188473; rs7045272; rs34721662; rs34190050; rs1408326; rs11327991; rs34108147; rs11286201; rs11789857; rs28931868; rs11307544; rs35917801; rs34037771; rs10820299; rs10820300; rs10990385; rs11788621; rs12350632; rs12552312; rs12555788; rs1887774; rs1887775; rs1927886; rs2025444; rs2031320; rs2031321; rs2476919; rs2479827; rs280661; rs33951726; rs34491501; rs3949818; rs4742910; rs4743712; rs4743713; rs4743715; rs7026934; rs7037304; rs7045639; rs8190581; rs9299367; rs958829; rs958830; rs958831

# Metabolic_Enzyme_13_General_References:
8075637; 8550739; 9758445; 9709959; 11158067

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5724

# Metabolic_Enzyme_14_Name:
UDP-glucuronosyltransferase 2A1 precursor

# Metabolic_Enzyme_14_Synonyms:
Not Available

# Metabolic_Enzyme_14_Gene_Name:
UGT2A1

# Metabolic_Enzyme_14_Protein_Sequence:
>UDPglucuronosyltransferase 2A1 precursor
MLNNLLLFSLQISLIGTTLGGNVLIWPMEGSHWLNVKIIIDELIKKEHNVTVLVASGALF
ITPTSNPSLTFEIYKVPFGKERIEGVIKDFVSTWLENRPSPSTIWRFYQEMAKVIKDFHM
VSQEICDGVLKNQQLMAKLKKSKFEVLVSDPVFPCGDIVALKLGIPFMYSLRFSPASTVE
KHCGKVPYPPSYVPAVLSELTDQMSFTDRIRNFISYHLQDYMFETLWKSWDSYYSKALGR
PTTLCETMGKAEIWLIRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFIQSSGKN
GVVVFSLGSMVKNLTEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDL
LGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTS
VDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHD
LTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKFGKIGKKKKRE

# Metabolic_Enzyme_14_Number_of_Residues:
527

# Metabolic_Enzyme_14_Molecular_Weight:
59873

# Metabolic_Enzyme_14_Theoretical_pI:
9.29

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform is active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium

# Metabolic_Enzyme_14_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_14_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_14_Signals:
1-20

# Metabolic_Enzyme_14_Transmembrane_Regions:
491-507

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_14_GenBank_ID_Protein:
4753766

# Metabolic_Enzyme_14_SwissProt_ID:
UDA1_HUMAN (Q9Y4X1)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
UGT2A1

# Metabolic_Enzyme_14_Geneatlas_id:
UGT2A1

# Metabolic_Enzyme_14_hgnc_id:
HGNC:12542

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Membrane

# Metabolic_Enzyme_14_Gene_Sequence:
>1584 bp
ATGTTAAACAACCTTCTGCTGTTCTCCCTTCAGATAAGTCTCATAGGAACCACTCTTGGT
GGGAATGTTTTGATTTGGCCAATGGAAGGTAGTCATTGGCTAAATGTTAAGATAATTATA
GATGAGCTCATTAAAAAGGAGCATAATGTGACTGTCCTAGTTGCCTCTGGTGCACTTTTC
ATCACACCAACCTCTAACCCATCTCTGACATTTGAAATATATAAGGTGCCCTTTGGCAAA
GAAAGAATAGAAGGAGTAATTAAGGACTTCGTTTCGACATGGCTGGAAAATAGACCATCT
CCTTCAACCATTTGGAGATTCTATCAGGAGATGGCCAAAGTAATCAAGGACTTCCACATG
GTGTCTCAGGAGATCTGTGATGGCGTTCTTAAAAACCAACAGCTGATGGCAAAGCTAAAG
AAAAGCAAGTTTGAAGTCCTGGTGTCTGATCCAGTATTTCCTTGTGGCGATATAGTAGCT
TTAAAACTTGGAATTCCATTTATGTACTCCTTGAGGTTTTCTCCAGCCTCAACAGTGGAA
AAGCACTGTGGGAAGGTACCATACCCTCCTTCCTATGTTCCTGCTGTTTTATCAGAACTC
ACCGACCAAATGTCTTTCACTGACAGAATAAGAAATTTCATCTCCTACCACCTACAGGAC
TACATGTTTGAAACTCTTTGGAAATCATGGGATTCATACTATAGTAAAGCTTTAGGAAGA
CCCACTACGTTATGTGAGACTATGGGGAAAGCTGAAATTTGGTTAATCCGAACATATTGG
GATTTTGAATTTCCTCGTCCATACTTACCTAATTTTGAGTTTGTTGGAGGATTGCACTGC
AAACCTGCCAAACCTTTACCTAAGGAAATGGAAGAATTTATCCAGAGCTCAGGTAAAAAT
GGTGTTGTGGTGTTTTCTCTGGGATCAATGGTCAAAAACCTTACAGAAGAAAAGGCCAAT
CTTATTGCCTCAGCCCTTGCCCAGATTCCACAGAAGGTTTTATGGAGATACAAAGGAAAG
AAACCAGCCACATTAGGAAACAATACTCAGCTCTTTGATTGGATACCCCAGAATGATCTT
CTTGGACATCCCAAAACCAAAGCTTTTATCACTCATGGTGGAACTAATGGGATCTACGAA
GCTATTTACCACGGAGTCCCTATGGTGGGAGTTCCCATGTTTGCTGATCAGCCTGATAAC
ATTGCTCACATGAAGGCCAAAGGAGCAGCTGTGGAAGTGAACCTAAACACAATGACAAGT
GTGGATTTGCTTAGCGCTTTGAGAACAGTCATTAATGAACCTTCTTATAAAGAGAATGCT
ATGAGGTTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTGGATCGAGCAGTCTTC
TGGATCGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTTCGGGTTGCAGCCCATGAC
CTCACCTGGTTCCAGTACCACTCTTTGGATGTAATTGGGTTCTTGCTGGTCTGTGTGACA
ACGGCTATATTTTTGGTCATACAATGTTGTTTGTTTTCCTGTCAAAAATTTGGTAAGATA
GGAAAGAAGAAAAAAAGAGAATAG

# Metabolic_Enzyme_14_GenBank_ID_Gene:
AJ006054

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_14_Locus:
4q13

# Metabolic_Enzyme_14_SNPs:
rs4148301; rs4148304; rs2163659; rs7668703; rs1432329; rs1432332; rs7659937; rs7672805; rs979363; rs10000435; rs4148279; rs10028495; rs7656541; rs6835972; rs4148276; rs1432330; rs4148277; rs6600796; rs1821185; rs1432335; rs1432336; rs1319811; rs7671313; rs10903210; rs7689493; rs10013528; rs9992698; rs988671; rs6842466; rs6825253; rs4148291; rs11728546; rs2331685; rs2017370; rs4694225; rs6832424; rs6600793; rs1432324; rs1560605; rs2163658; rs4148308; rs4401516; rs6600794; rs988672; rs3775783; rs1036160; rs7655867; rs6854350; rs1835826; rs4148295; rs2288740; rs2288741; rs1438537; rs1432316; rs6853543; rs11249451; rs1158439; rs4148281; rs10001991; rs11946382; rs10518063; rs2033798; rs6600792; rs4048747; rs1432314; rs10033801; rs7676249; rs10026988; rs10028954; rs7662867; rs1432315; rs11249452; rs1835821; rs10006049; rs4148289; rs10011630; rs7662309; rs4148298; rs10021575; rs17147507; rs9999694; rs6846404; rs4694219; rs17147542; rs7692074; rs10023821; rs11933160; rs7662915; rs1967984; rs6855271; rs4148292; rs11249454; rs10033879; rs1432313; rs7685874; rs17147532; rs7665571; rs11736315; rs4473712; rs10023782; rs4694222; rs7670819; rs7699881; rs6824954; rs11936310; rs11936130; rs6600795; rs1432327; rs10011912; rs3822178; rs1835829; rs9999430; rs6848997; rs1835822; rs11942157; rs4148290; rs17674565; rs17674511; rs10004306; rs6811810; rs4148297; rs17618404; rs1583243; rs6858314; rs10012508; rs6832784; rs2217587; rs3775782; rs12507278; rs6855294; rs17147530; rs11731188; rs10009530; rs6824830; rs13129549; rs6831807; rs11736373; rs10006483; rs17618520; rs17680131; rs7680856; rs4148286; rs11931365; rs10023877; rs17618178; rs11722780; rs10027493; rs6826237; rs17147521; rs11249453; rs7688383; rs4148299; rs4148302; rs9997689; rs6814603; rs7681367; rs17674648; rs9917881; rs4148296; rs11721934; rs4148283; rs6849110; rs12501520; rs4148307; rs11736353; rs13120401; rs4550998; rs4148309; rs6839067; rs6852329; rs7670238; rs7668967; rs11946584; rs10022954; rs6832167; rs2010207; rs12500392; rs7690649; rs17617467; rs10013712; rs9993182; rs6846030; rs4148305; rs17618230; rs10026603; rs4694027; rs4148288; rs6831951; rs11730451; rs10005934; rs1897441; rs4395582; rs11729544; rs4148312; rs4280808; rs10518065; rs11929943; rs11929908; rs10033854; rs17147557; rs1550292; rs13134357; rs11939884; rs1432334; rs1432333; rs17619211; rs17681080; rs10471252; rs1347046; rs41292307; rs4148310; rs41292305; rs35926238; rs4148275; rs7674020; rs35816431; rs34251717; rs11438429; rs4148311; rs4694226; rs1368116; rs35378505; rs34607614; rs4148278; rs10649712; rs10682826; rs188964; rs11732515; rs192970; rs11725441; rs28448316; rs33924396; rs28798793; rs17147492; rs324309; rs28413749; rs17147503; rs17147534; rs28404221; rs6600791; rs28570072; rs33943659; rs34090224; rs35971542; rs11460578; rs33999522; rs11441625; rs11323266; rs35281757; rs7677083; rs28776197; rs28782228; rs35910775; rs10583998; rs12644575; rs1967983; rs34446108; rs34142192; rs28544323; rs4148294; rs35582043; rs189787; rs4148285; rs11931171; rs2033801; rs11319385; rs11279957; rs5859193; rs324313; rs4148282; rs33938194; rs7377236; rs34704021; rs36106673; rs28818211; rs28532778; rs34265777; rs4148303; rs13119853; rs36003863; rs1583242; rs34513233; rs985040; rs7686386; rs10691812; rs34650072; rs13112999; rs11721725; rs28759827; rs28726183; rs34028035; rs324310; rs4409023; rs4148320; rs13131759; rs33953975; rs17147520; rs36051343; rs35795947; rs7672793; rs36163528; rs34021488; rs11733854; rs11721681; rs7669007; rs13149874; rs4148322; rs36083211; rs34789624; rs35333044; rs28560222; rs7693686; rs34698455; rs4148306; rs7657761; rs34909158; rs5859194; rs34670944; rs35243459; rs34139484; rs35400584; rs28689093; rs188966; rs11946796; rs11947056; rs11733907; rs28568390; rs34647023; rs10010846; rs6813494; rs7698372; rs28716091; rs10023818; rs35302832; rs34810925; rs34370025; rs4148313; rs4148287; rs34213902; rs35487350; rs35071017; rs10569499; rs33913173; rs28522985; rs34858243; rs28556671; rs34208726; rs34396917; rs4148284; rs11728785; rs28560191; rs28513556; rs28508252; rs36191379; rs4148316; rs4148280; rs4148293; rs7668214; rs2877457; rs34817437; rs2116564; rs11940905; rs10017134; rs28528833; rs35101874; rs33976214; rs34975164; rs34590689; rs34452487; rs2043241; rs3074345; rs35227598; rs34012364; rs34002846; rs28744454; rs34078716; rs34062331; rs5859195; rs35000204; rs33992705; rs10031145; rs33924614; rs11937993; rs13115454; rs1347047; rs1432317; rs1835830; rs4333255; rs6810459; rs7671030; rs7671041; rs7674562; rs7694939; rs9329029; rs9996459

# Metabolic_Enzyme_14_General_References:
10359671

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5734

# Metabolic_Enzyme_15_Name:
UDP-glucuronosyltransferase 2B11 precursor

# Metabolic_Enzyme_15_Synonyms:
UDPGT

# Metabolic_Enzyme_15_Gene_Name:
UGT2B11

# Metabolic_Enzyme_15_Protein_Sequence:
>UDPglucuronosyltransferase 2B11 precursor
MTLKWTSVLLLIHLSCYFSSGSCGKVLVWAAEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDASTLKFEVYPTSLTKTEFENIIMQQVKRWSDIRKDSFWLYFSQEQEILWELY
DIFRNFCKDVVSNKKVMKKLQESRFDIVFADAVFPCGELLAALLNIRFVYSLRFTPGYTI
ERHSGGLIFPPSYIPIVMSKLSDQMTFMERVKNMIYVLYFDFWFQMSDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNVDFVGGFHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRLDFNTM
SSTDLLNALKTVINDPLYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMPHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLACVATVIFIITKFCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_15_Number_of_Residues:
529

# Metabolic_Enzyme_15_Molecular_Weight:
61039

# Metabolic_Enzyme_15_Theoretical_pI:
9.29

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_15_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_15_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_15_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_15_Signals:
1-21

# Metabolic_Enzyme_15_Transmembrane_Regions:
493-513

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_15_GenBank_ID_Protein:
3360273

# Metabolic_Enzyme_15_SwissProt_ID:
UDB11_HUMAN (O75310)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
UGT2B11

# Metabolic_Enzyme_15_Geneatlas_id:
UGT2B11

# Metabolic_Enzyme_15_hgnc_id:
HGNC:12545

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Microsome

# Metabolic_Enzyme_15_Gene_Sequence:
>1590 bp
ATGACTCTGAAATGGACTTCAGTTCTTCTGCTGATACATCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAAGTGCTGGTGTGGGCCGCAGAATACAGCCATTGGATGAATATGAAG
ACAATCCTGAAAGAGCTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAATGATGCATCCACTCTTAAATTTGAAGTTTATCCTACATCT
TTAACTAAAACTGAATTTGAGAATATCATCATGCAACAGGTTAAGAGATGGTCAGACATT
CGAAAAGATAGCTTTTGGTTATATTTTTCACAAGAACAAGAAATCCTGTGGGAATTATAT
GACATATTTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAAGTTATGAAAAAACTA
CAAGAGTCAAGATTTGACATCGTTTTTGCAGATGCTGTTTTTCCCTGTGGTGAGCTGCTG
GCTGCGCTACTTAACATACGGTTTGTGTACAGTCTCCGCTTTACTCCTGGCTACACAATT
GAAAGGCACAGTGGAGGACTGATTTTCCCTCCTTCCTACATACCTATTGTTATGTCAAAA
TTAAGTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTATTTT
GACTTTTGGTTCCAAATGTCTGATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTA
GGAAGACCCACTACCTTATTTGAGACAATGGGAAAAGCTGACATATGGCTTATGCGAAAC
TCCTGGAGTTTTCAATTTCCTCATCCATTCTTACCAAACGTTGATTTTGTTGGAGGATTC
CACTGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAGTTTGTACAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAGTGATAAGTAACATGACAGCAGAAAGG
GCCAATGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAC
GGGAATAAACCAGATGCCTTAGGTCTCAATACTCGGCTGTACAAGTGGATACCCCAGAAT
GACCTTCTAGGTCATCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATGAGGCAATCTACCATGGGATCCCTATGGTGGGCATTCCATTGTTTTTTGATCAACCT
GATAACATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGATTGGACTTCAACACAATG
TCGAGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTTATATAAAGAG
AATATTATGAAATTATCAAGAATTCAACATGATCAACCAGTAAAGCCCCTGGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCCCCACAAAGGAGCCAAACACCTTCGAGTTGCAGCC
CATGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTTCTGCTGGCCTGT
GTGGCAACTGTGATATTTATCATCACAAAGTTTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGGGAAGAAGGGAAAAAGAGATTAG

# Metabolic_Enzyme_15_GenBank_ID_Gene:
AF016492

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_15_Locus:
4q13.2

# Metabolic_Enzyme_15_SNPs:
rs4694697; rs4415023; rs4400059; rs4543201; rs4283741; rs11945946; rs7436729; rs11947293; rs4463131; rs6833028; rs12500268; rs4608875; rs7688262; rs7697037; rs3890590; rs7697482; rs35248576; rs11340393; rs5859168; rs4485863; rs28743034; rs4619960; rs13148581; rs13113479; rs4406085; rs34519957; rs13119196; rs28561592; rs4406086; rs13134572; rs7660257; rs13148525; rs35902951; rs13148376; rs4386666; rs13134364; rs13113695; rs4485864; rs13107183; rs7660248; rs13119170; rs13103028; rs13134363; rs35555504; rs13139597; rs35443238; rs28470680; rs13113271; rs13119197; rs13107219; rs10007587; rs4466107; rs10434518; rs34416320; rs10007579; rs6847476; rs10012181; rs9996390; rs12502502; rs13123057; rs4526045; rs4694199; rs6817250; rs6825376; rs7672567; rs7682460; rs7695331

# Metabolic_Enzyme_15_General_References:
9675083

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5725

# Metabolic_Enzyme_16_Name:
UDP-glucuronosyltransferase 1-1 precursor

# Metabolic_Enzyme_16_Synonyms:
UDP- glucuronosyltransferase 1A1; UDPGT; UGT1*1; UGT1-01; UGT1.1; UGT- 1A; UGT1A; Bilirubin-specific UDPGT isozyme 1; HUG-BR1

# Metabolic_Enzyme_16_Gene_Name:
UGT1A1

# Metabolic_Enzyme_16_Protein_Sequence:
>UDPglucuronosyltransferase 11 precursor
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_16_Number_of_Residues:
533

# Metabolic_Enzyme_16_Molecular_Weight:
59592

# Metabolic_Enzyme_16_Theoretical_pI:
8.09

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_16_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

# Metabolic_Enzyme_16_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_16_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_16_Signals:
1-25

# Metabolic_Enzyme_16_Transmembrane_Regions:
491-507

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_16_GenBank_ID_Protein:
184473

# Metabolic_Enzyme_16_SwissProt_ID:
UD11_HUMAN (P22309)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
UGT1A1

# Metabolic_Enzyme_16_Geneatlas_id:
UGT1A1

# Metabolic_Enzyme_16_hgnc_id:
HGNC:12530

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Microsome

# Metabolic_Enzyme_16_Gene_Sequence:
>1602 bp
ATGGCTGTGGAGTCCCAGGGCGGACGCCCACTTGTCCTGGGCCTGCTGCTGTGTGTGCTG
GGCCCAGTGGTGTCCCATGCTGGGAAGATACTGTTGATCCCAGTGGATGGCAGCCACTGG
CTGAGCATGCTTGGGGCCATCCAGCAGCTGCAGCAGAGGGGACATGAAATAGTTGTCCTA
GCACCTGACGCCTCGTTGTACATCAGAGACGGAGCATTTTACACCTTGAAGACGTACCCT
GTGCCATTCCAAAGGGAGGATGTGAAAGAGTCTTTTGTTAGTCTCGGGCATAATGTTTTT
GAGAATGATTCTTTCCTGCAGCGTGTGATCAAAACATACAAGAAAATAAAAAAGGACTCT
GCTATGCTTTTGTCTGGCTGTTCCCACTTACTGCACAACAAGGAGCTCATGGCCTCCCTG
GCAGAAAGCAGCTTTGATGTCATGCTGACGGACCCTTTCCTTCCTTGCAGCCCCATCGTG
GCCCAGTACCTGTCTCTGCCCACTGTATTCTTCTTGCATGCACTGCCATGCAGCCTGGAA
TTTGAGGCTACCCAGTGCCCCAACCCATTCTCCTACGTGCCCAGGCCTCTCTCCTCTCAT
TCAGATCACATGACCTTCCTGCAGCGGGTGAAGAACATGCTCATTGCCTTTTCACAGAAC
TTTCTGTGCGACGTGGTTTATTCCCCGTATGCAACCCTTGCCTCAGAATTCCTTCAGAGA
GAGGTGACTGTCCAGGACCTATTGAGCTCTGCATCTGTCTGGCTGTTTAGAAGTGACTTT
GTGAAGGATTACCCTAGGCCCATCATGCCCAATATGGTTTTTGTTGGTGGAATCAACTGC
CTTCACCAAAATCCACTATCCCAGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACAT
GGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATG
GCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACC
CGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTG
CTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAA
AGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAAT
GCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCT
GAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATC
ATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTC
TGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGAC
CTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTG
ACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAA
AAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
M57899

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_16_Locus:
2q37

# Metabolic_Enzyme_16_SNPs:
Not Available

# Metabolic_Enzyme_16_General_References:
1898728; 1339448; 11434514; 1634050; 8280139; 8276413; 8226884; 7989045; 7989595; 7715297; 9621515; 9627603

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5696

# Metabolic_Enzyme_17_Name:
UDP-glucuronosyltransferase 2B4 precursor

# Metabolic_Enzyme_17_Synonyms:
UDPGT; Hyodeoxycholic acid; HLUG25; UDPGTh-1

# Metabolic_Enzyme_17_Gene_Name:
UGT2B4

# Metabolic_Enzyme_17_Protein_Sequence:
>UDPglucuronosyltransferase 2B4 precursor
MSMKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLASSA
SISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFN
DILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFGELLAELLKIPFVYSLRFSPGYAI
EKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVL
GRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSMVSNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTM
SSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVTGFLLACVATVIFIITKCLFCVWKFVRTGKKGKRD

# Metabolic_Enzyme_17_Number_of_Residues:
528

# Metabolic_Enzyme_17_Molecular_Weight:
60513

# Metabolic_Enzyme_17_Theoretical_pI:
8.75

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_17_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid

# Metabolic_Enzyme_17_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_17_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_17_Signals:
1-23

# Metabolic_Enzyme_17_Transmembrane_Regions:
493-509

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_17_GenBank_ID_Protein:
37589

# Metabolic_Enzyme_17_SwissProt_ID:
UDB4_HUMAN (P06133)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
UGT2B4

# Metabolic_Enzyme_17_Geneatlas_id:
UGT2B4

# Metabolic_Enzyme_17_hgnc_id:
HGNC:12553

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Microsome

# Metabolic_Enzyme_17_Gene_Sequence:
>1587 bp
ATGTCTATGAAATGGACTTCAGCTCTTCTGCTGATACAGCTGAGCTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATTCAGCCACTGGATGAATATAAAG
ACAATCCTGGATGAACTTGTCCAGAGAGGTCATGAGGTGACTGTATTGGCATCTTCAGCT
TCCATTTCTTTCGATCCCAACAGCCCATCTACTCTTAAATTTGAAGTTTATCCTGTATCT
TTAACTAAAACTGAGTTTGAGGATATTATCAAGCAGCTGGTTAAGAGATGGGCAGAACTT
CCAAAAGACACATTTTGGTCATATTTTTCACAAGTACAAGAAATCATGTGGACATTTAAT
GACATACTTAGAAAGTTCTGTAAGGATATAGTTTCAAATAAGAAACTTATGAAGAAACTA
CAGGAGTCAAGATTTGATGTTGTTCTTGCAGATGCTGTTTTCCCCTTTGGTGAGCTGCTG
GCCGAGTTACTTAAAATACCCTTTGTCTACAGGCCTCGCTTCTCTCCTGGCTACGCAATT
GAAAAGCATAGTGGAGGACTTCTGTTCCCTCCTTCCTATGTGCCTGTTGTTATGTCAGAA
CTAAGTGACCAAATGACTTTCATAGAGAGGGTAAAAAATATGATCTATGTGCTTTATTTT
GAATTTTGGTTCCAAATATTTGACATGAAGAAGTGGGATCAGTTCTACAGTGAAGTTCTA
GGAAGACCCACTACGTTATCTGAGACAATGGCAAAAGCTGACATATGGCTTATTCGAAAC
TACTGGGATTTTCAATTTCCTCACCCACTCTTACCAAATGTTGAGTTCGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTACCGAAGGAAATGGAAGAGTTTGTCCAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCGATGGTCAGTAACACGTCAGAAGAAAGG
GCCAATGTAATTGCATCAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATACTTTAGGACTCAATACTCGGCTGTACAAGTGGATACCCCAGAAT
GATCTTCTTGGTCACCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATAAGGCAATCTCTCCTAGAATCCCTATGGTGGGCGTTCCATTGTTTGCAGATCAACCT
GATAACATTGCACACATGAAGGCCAAGGGAGCAGCTGTTAGTTTGGACTTCCACACAATG
TCGAGTACAGACTTACTCAATGCACTGAAGACAGTAATTAATGATCCTTTATATAAAGAG
AATGCTATGAAATTATCAAGAATTCATCATGATCAACCAGTGAAGCCCCTTGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTTGCAGCC
CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGACTGGGTTCCTGCTGGCCTGT
GTGGCAACTGTGATATTCATCATCACAAAATGTCTGTTTTGTGTCTGGAAGTTTGTTAGA
ACAGGAAAGAAGGGGAAAAGAGATTAA

# Metabolic_Enzyme_17_GenBank_ID_Gene:
Y00317

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_17_Locus:
4q13

# Metabolic_Enzyme_17_SNPs:
rs13119049; rs41297431; rs13142440; rs1131878; rs1966151; rs1051752; rs7662902; rs1389930; rs1826690; rs7441743; rs1039007; rs2220857; rs2013562; rs1845557; rs6833511; rs13116232; rs12645716; rs9997034; rs1994936; rs1039008; rs4554145; rs28542932; rs10030234; rs10518061; rs17614939; rs13104260; rs10010875; rs3822179; rs33914959; rs1845556; rs6848208; rs17671289; rs1977017; rs28361541; rs41297733; rs41297437; rs1997581; rs41297373; rs41299996; rs41297395; rs41297371; rs41300016; rs41297381; rs41297421; rs1908406; rs41297427; rs41297377; rs41297425; rs41297367; rs4557343; rs1845558; rs3075630; rs41297405; rs41297739; rs41297383; rs41297721; rs13151870; rs41297441; rs13145834; rs13104687; rs11249442; rs41297407; rs41297429; rs41297727; rs1121124; rs2013573; rs41299994; rs13139888; rs41297439; rs41297409; rs1494802; rs13111134; rs6600771; rs6820660; rs6821129; rs941389; rs2736446; rs1080755; rs2736442; rs28858389; rs2736441; rs41298271; rs41298263; rs41299972; rs41298261; rs41298251; rs13129471; rs41299970; rs6821910; rs41298253; rs41298259; rs41298265; rs41298245; rs41299978; rs41299976; rs41299974; rs41300004; rs17852375; rs1845555; rs41298247; rs28679647; rs324405; rs41300006; rs36048401; rs1432328; rs41297387; rs41299984; rs41299998; rs41299992; rs41297735; rs41297423; rs35143721; rs1370886; rs41299980; rs41297389; rs41297729; rs7441132; rs41297435; rs34002802; rs41297731; rs41300018; rs35138624; rs41297391; rs41297369; rs41297737; rs41297413; rs13141359; rs41292303; rs41300008; rs2736447; rs41300014; rs41297401; rs34874998; rs1370887; rs41297399; rs41297379; rs172861; rs41297375; rs10613760; rs41297433; rs41297723; rs41297403; rs41297741; rs1821190; rs34030380; rs324406; rs41299986; rs41297393; rs41297385; rs41297419; rs41297365; rs35471760; rs34861432; rs4515233; rs324408; rs41297411; rs2018304; rs41300012; rs13114834; rs41297415; rs28629208; rs41300002; rs41300000; rs41300010; rs41297743; rs41297397; rs41299990; rs28419590; rs983988; rs34164957; rs1370885; rs324407; rs34466016; rs41297725; rs41297417; rs34114694; rs41299988; rs41299982; rs41299966; rs34846583; rs35045255; rs35834953; rs34169605; rs1318156; rs2642856; rs35159034; rs41298257; rs41298249; rs2736445; rs3075626; rs41299968; rs28847667; rs34146174; rs36057237; rs28812576; rs941390; rs41298255; rs28894673; rs41298269; rs1080756; rs41298267; rs10000231; rs10015297; rs11725944; rs11725945; rs13141436; rs13143630; rs1569343; rs1569344; rs1594588; rs1603119; rs1948499; rs2010468; rs2642849; rs2642872; rs2736462; rs2736476; rs2736517; rs2736520; rs35347166; rs4694749; rs7657880; rs903445; rs903446; rs9996511

# Metabolic_Enzyme_17_General_References:
3109396; 8333863; 10376768

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5685

# Metabolic_Enzyme_18_Name:
Estradiol 17-beta-dehydrogenase 2

# Metabolic_Enzyme_18_Synonyms:
17-beta-HSD 2; Microsomal 17-beta-hydroxysteroid dehydrogenase; 20 alpha- hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH

# Metabolic_Enzyme_18_Gene_Name:
HSD17B2

# Metabolic_Enzyme_18_Protein_Sequence:
>Estradiol 17betadehydrogenase 2
MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL
FSVSCFLMYT
YLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGP
GAEELRRTCSPRLSVLQMDIT
KPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGE
LLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKS
KGRLVNVSSMGGGAPMERLASYGSSKA
AVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLE
KDILDHLPAEVQEDYG
QDYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICL
AHYLP
IGIYDYFAKRHFGQDKPMPRALRMPNYKKKAT

# Metabolic_Enzyme_18_Number_of_Residues:
387

# Metabolic_Enzyme_18_Molecular_Weight:
42786

# Metabolic_Enzyme_18_Theoretical_pI:
8.62

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_18_Specific_Function:
Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH

# Metabolic_Enzyme_18_Pathway:
map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_18_Reaction:
estradiol-17beta + NAD(P)+ = estrone + NAD(P)H + H+

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_18_Signals:
1-20

# Metabolic_Enzyme_18_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 1.1.1.62

# Metabolic_Enzyme_18_GenBank_ID_Protein:
306462

# Metabolic_Enzyme_18_SwissProt_ID:
DHB2_HUMAN (P37059)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
HSD17B2

# Metabolic_Enzyme_18_Geneatlas_id:
HSD17B2

# Metabolic_Enzyme_18_hgnc_id:
HGNC:5211

# Metabolic_Enzyme_18_PDB_ID:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Metabolic_Enzyme_18_Gene_Sequence:
>1164 bp

ATGAGCACTTTCTTCTCGGACACAGCATGGATCTGCCTGGCTGTCCCCACAGTACTATG
TGGGACAGTAT
TTTGCAAATACAAGAAGAGCTCAGGGCAGCTGTGGAGCTGGATGGTCT
GCCTGGCAGGCCTCTGTGCAGT
CTGCCTGCTCATCCTGTCCCCTTTTTGGGGCTTGATC
CTCTTCTCGGTGTCATGCTTCCTCATGTATACT
TACTTATCTGGCCAAGAATTGTTACC
TGTGGATCAGAAGGCAGTCCTGGTGACAGGTGGTGATTGCGGGC
TTGGCCATGCTTTGT
GCAAGTATCTGGATGAGCTGGGCTTCACGGTATTTGCCGGAGTTTTGAATGAAAA
TGGC
CCAGGAGCTGAGGAATTGCGAAGAACCTGCTCTCCGCGCCTCTCGGTGCTCCAAATGGAC
ATCACG
AAGCCAGTGCAGATAAAAGATGCTTACAGCAAGGTTGCAGCAATGCTGCAGGA
CAGAGGACTGTGGGCTG
TGATCAACAATGCTGGGGTGCTTGGCTTTCCAACTGATGGGG
AGCTTCTTCTTATGACTGACTACAAACA
ATGCATGGCCGTGAACTTCTTTGGAACTGTG
GAGGTCACAAAGACGTTTTTGCCTCTTCTTAGAAAATCC
AAAGGGAGGCTGGTGAATGT
CAGCAGCATGGGAGGAGGGGCCCCAATGGAAAGGCTGGCATCTTATGGCT
CATCAAAGG
CGGCTGTGACCATGTTCTCATCAGTTATGAGACTGGAGCTTTCCAAGTGGGGAATTAAAG
T
TGCTTCCATCCAACCTGGAGGCTTCCTAACAAATATCGCAGGCACCAGTGACAAGTGG
GAAAAGCTGGAG
AAGGACATTCTGGACCACCTCCCCGCTGAGGTACAGGAAGACTACGG
CCAGGACTACATCTTAGCACAGC
GGAATTTCCTCCTATTGATCAACTCGTTAGCCAGCA
AGGACTTCTCTCCGGTGCTGCGGGACATCCAGCA
TGCTATCTTGGCGAAGAGCCCTTTT
GCCTATTACACGCCAGGGAAAGGCGCTTACTTGTGGATCTGCCTT
GCTCACTATTTGCC
TATTGGCATATATGATTACTTTGCTAAAAGACATTTTGGCCAAGACAAGCCCATGC
CCA
GAGCTCTAAGAATGCCTAACTACAAGAAAAAGGCCACCTAG

# Metabolic_Enzyme_18_GenBank_ID_Gene:
L11708

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_18_Locus:
16q24.1-q24.2

# Metabolic_Enzyme_18_SNPs:
rs8191136; rs8191246; rs8191135; rs8191244; rs4445895; rs2966250; rs1364285; rs1364286; rs2042429; rs1017242; rs2966245; rs2955152; rs2955163; rs2966249; rs1364287; rs2955162; rs1017243; rs8046533; rs7196807; rs8060685; rs2966246; rs1424151; rs8191080; rs8049510; rs7200711; rs7203384; rs7205968; rs4318193; rs1559428; rs7201637; rs8191068; rs8191077; rs9319572; rs8049006; rs8049423; rs2911422; rs8191112; rs8050327; rs2966244; rs723012; rs4628962; rs4889456; rs8049750; rs8047385; rs7200696; rs2911420; rs7201121; rs2955159; rs8048090; rs4889453; rs8191089; rs9940004; rs8048018; rs7192075; rs11150437; rs8191167; rs11150436; rs8044837; rs8052451; rs7196087; rs8191156; rs3751860; rs7196609; rs6564961; rs8044382; rs8191159; rs11648233; rs11863907; rs8046220; rs8045494; rs2873459; rs2966241; rs16956274; rs7498701; rs723013; rs8191160; rs8056343; rs16956373; rs8191175; rs4888202; rs8191113; rs4889457; rs11150435; rs11642323; rs1559427; rs16956356; rs7184155; rs7184121; rs8191088; rs4398102; rs8191163; rs1816121; rs8191114; rs9929854; rs8191138; rs8191057; rs8059915; rs10514523; rs8191235; rs13339413; rs8191165; rs8191111; rs2966251; rs4480799; rs1559429; rs8191097; rs4497679; rs10514522; rs8191058; rs9788807; rs1981878; rs8191183; rs8191102; rs8191146; rs8191072; rs8061074; rs8191243; rs4468615; rs3111351; rs11865667; rs11865023; rs11150434; rs8191120; rs4243229; rs8191119; rs7186963; rs8191101; rs4453484; rs8054838; rs8191144; rs9889094; rs9939740; rs8191134; rs2955160; rs4589548; rs8191169; rs11860188; rs2966248; rs8191094; rs13337293; rs8191170; rs2317419; rs9934209; rs8191208; rs6564962; rs8191066; rs8191143; rs8191125; rs2955156; rs16956282; rs8191110; rs8191236; rs8191065; rs8191105; rs8191154; rs9934783; rs8191055; rs7203108; rs11867054; rs8191126; rs8191220; rs16956406; rs8191177; rs8191056; rs8191115; rs16956279; rs8191237; rs4889452; rs8191157; rs1981880; rs8191118; rs2955155; rs16956363; rs8191219; rs8191198; rs9925455; rs8191173; rs8191070; rs8191123; rs8191194; rs8191207; rs8191121; rs8191152; rs8191069; rs8191141; rs8191099; rs8191117; rs2955153; rs8191184; rs8191206; rs8191212; rs8191095; rs8191148; rs8191197; rs8191084; rs8191226; rs8062467; rs8191100; rs8191147; rs11645641; rs8191122; rs7499494; rs8191140; rs8191174; rs8191204; rs9931597; rs8191155; rs8191137; rs2911417; rs16956276; rs2911418; rs1981879; rs8191186; rs11647954; rs8191129; rs8191232; rs8191132; rs8191233; rs8191223; rs13331247; rs16956360; rs8191093; rs8191083; rs8191164; rs8191062; rs8191158; rs8191205; rs8191171; rs8191178; rs8191192; rs8191131; rs8191124; rs8191242; rs16956351; rs2955151; rs8191224; rs7205168; rs8191195; rs8191130; rs7203506; rs8182164; rs4258604; rs8191225; rs8191188; rs2873503; rs8191127; rs8191202; rs16956292; rs8191081; rs7189128; rs8191181; rs8191210; rs16956326; rs8191241; rs8191142; rs6564964; rs7206573; rs8191231; rs8191180; rs8191073; rs8191071; rs8191059; rs4587969; rs8191161; rs8191082; rs13337657; rs2955157; rs8191054; rs8191211; rs8061420; rs8191075; rs8055526; rs4889451; rs8061331; rs8054931; rs8191049; rs8191048; rs8191248; rs8191050; rs8045403; rs8191044; rs8191047; rs8191045; rs8191051; rs3841245; rs34731990; rs12926193; rs8191053; rs8191245; rs8191052; rs8191209; rs7195902; rs8191109; rs8047676; rs35542346; rs8191116; rs34663442; rs8191168; rs11316956; rs8191201; rs7185224; rs12935336; rs16956349; rs2911419; rs8191196; rs8191086; rs8191063; rs8191218; rs35477676; rs4595797; rs8191079; rs35929573; rs12934918; rs10714516; rs10609893; rs8191067; rs8191074; rs35094236; rs35553743; rs8191191; rs28415730; rs8191087; rs1559430; rs8191234; rs8191104; rs12921045; rs7359416; rs16956334; rs34787393; rs5818365; rs8191185; rs11336584; rs8060661; rs7201778; rs7200873; rs2042428; rs35106065; rs8191098; rs8191064; rs2966243; rs8191090; rs2955154; rs28720979; rs12930423; rs34014888; rs8191061; rs4602032; rs7359419; rs28458323; rs10655291; rs11447223; rs8191149; rs8191078; rs34076692; rs34972528; rs8191085; rs35003963; rs7359420; rs5818366; rs34304419; rs35200926; rs8191106; rs8191214; rs8191213; rs12934750; rs35421064; rs34511068; rs12933612; rs35272646; rs1034475; rs34184569; rs8191230; rs7185037; rs12149935; rs34364464; rs8051789; rs11354860; rs10565122; rs7195231; rs8191150; rs8191215; rs8044959; rs12930422; rs8191228; rs11865855; rs34353182; rs8191187; rs34165598; rs8191145; rs8191182; rs8191172; rs8191096; rs8191162; rs8191076; rs13330917; rs8191139; rs8191240; rs5818364; rs8191153; rs8191060; rs8191216; rs2113283; rs7189336; rs2955158; rs7359410; rs35072627; rs35417845; rs12103269; rs8191227; rs34860346; rs10565056; rs2911421; rs8191107; rs8057705; rs2966247; rs8191176; rs4447422; rs8191238; rs8059728; rs8191166; rs12918089; rs35162139; rs8191151; rs8191108; rs8191091; rs8191221; rs8191199; rs8191200; rs8191229; rs8191217; rs8191222; rs8191189; rs35078894; rs8191133; rs8191103; rs8191239; rs8191128; rs12600162; rs16956386; rs34530732; rs8063624; rs8191092; rs8191190; rs13330818; rs4293372; rs2955161; rs8191179; rs8191193; rs35439668; rs35457032; rs11428727; rs8191046; rs5818363; rs8191247; rs36081729; rs10595118; rs10514524; rs10514525; rs10514526; rs10514527; rs11150433; rs11150438; rs1119933; rs1157100; rs11643002; rs11649253; rs12919119; rs13333018; rs13333826; rs13380561; rs1364283; rs1364284; rs16956236; rs16956238; rs16956242; rs16956244; rs16956248; rs16956419; rs16956433; rs2317615; rs4262939; rs4274431; rs4291899; rs4378606; rs4635338; rs7188332; rs7190839; rs7198264; rs7202378; rs8044330; rs8046900; rs8055539; rs8060285; rs8060993; rs8063114; rs8064117; rs8191249; rs8191250; rs8191251; rs8191253; rs8191256; rs989018; rs989019; rs989020; rs9923501; rs9926000; rs9926211; rs9940683; rs996751; rs996752

# Metabolic_Enzyme_18_General_References:
8099587; 7546291

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5728

# Metabolic_Enzyme_19_Name:
UDP-glucuronosyltransferase 1-3 precursor

# Metabolic_Enzyme_19_Synonyms:
UDP- glucuronosyltransferase 1A3; UDPGT; UGT1*3; UGT1-03; UGT1.3; UGT- 1C; UGT1C

# Metabolic_Enzyme_19_Gene_Name:
UGT1A3

# Metabolic_Enzyme_19_Protein_Sequence:
>UDPglucuronosyltransferase 13 precursor
MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVV
LTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNM
SLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDL
DFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQ
REVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_19_Number_of_Residues:
534

# Metabolic_Enzyme_19_Molecular_Weight:
60339

# Metabolic_Enzyme_19_Theoretical_pI:
8.28

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_19_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_19_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_19_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_19_Signals:
1-28

# Metabolic_Enzyme_19_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_19_GenBank_ID_Protein:
340135

# Metabolic_Enzyme_19_SwissProt_ID:
UD13_HUMAN (P35503)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
UGT1A3

# Metabolic_Enzyme_19_Geneatlas_id:
UGT1A3

# Metabolic_Enzyme_19_hgnc_id:
HGNC:12535

# Metabolic_Enzyme_19_PDB_ID:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Microsome

# Metabolic_Enzyme_19_Gene_Sequence:
>867 bp
ATGGCCACAGGACTCCAGGTTCCCCTGCCGTGGCTGGCCACAGGACTGCTGCTTCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCATTGATGGCAGCCAC
TGGCTCAGCATGCGGGAGGTCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCAGTGGTC
CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAACTTTTTCACCCTGACAACCTAT
GCCATTTCGTGGACCCAGGATGAATTTGATCGCCATGTGCTGGGCCACACTCAACTGTAC
TTTGAAACAGAACATTTTCTGAAGAAATTTTTCAGAAGTATGGCAATGTTGAACAATATG
TCTTTGGTCTATCATAGGTCTTGTGTGGAGCTACTACATAATGAGGCCCTGATCAGGCAC
CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGCGCGGCAGTG
CTGGCTAAGTACCTGTCGATTCCTACTGTGTTTTTTTTGAGGAACATTCCATGTGATTTA
GACTTTAAGGGCACACAGTGTCCAAACCCTTCCTCCTATATTCCTAGATTACTAACAACC
AATTCAGACCACATGACATTCATGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACATTTGCCATGCTTTTTCTGCTCCTTATGCAAGCCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATATTCTCAGTCATGCATCTGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGACTACCCCAGGCCAATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACAGGAAGCCACTATCTCAG

# Metabolic_Enzyme_19_GenBank_ID_Gene:
M84127

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_19_Locus:
2q37

# Metabolic_Enzyme_19_SNPs:
Not Available

# Metabolic_Enzyme_19_General_References:
1339448; 11434514

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
5730

# Metabolic_Enzyme_20_Name:
UDP-glucuronosyltransferase 1-10 precursor

# Metabolic_Enzyme_20_Synonyms:
UDPGT; UGT1*10; UGT1-10; UGT1.10; UGT-1J; UGT1J

# Metabolic_Enzyme_20_Gene_Name:
UGT1A10

# Metabolic_Enzyme_20_Protein_Sequence:
>UDPglucuronosyltransferase 110 precursor
MARAGWTSPVPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLF
FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEG
AQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_20_Number_of_Residues:
530

# Metabolic_Enzyme_20_Molecular_Weight:
59810

# Metabolic_Enzyme_20_Theoretical_pI:
7.31

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_20_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_20_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_20_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_20_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_20_Signals:
1-25

# Metabolic_Enzyme_20_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_20_GenBank_ID_Protein:
2039362

# Metabolic_Enzyme_20_SwissProt_ID:
UD110_HUMAN (Q9HAW8)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
UGT1A10

# Metabolic_Enzyme_20_Geneatlas_id:
UGT1A10

# Metabolic_Enzyme_20_hgnc_id:
HGNC:12531

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Microsome

# Metabolic_Enzyme_20_Gene_Sequence:
>1593 bp
ATGGCTCCGCGCAGGGTGGACCAGCCCCGTTCCTTTATGTGTGTGTCTACTGCTGACCTG
TGGCTTTGCGAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGTCACTGGTTCGCC
ATGCAGTCGGTGGTGGAGAAACTTATCCTCAGGGGGCATGAGGTGGTTGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGAAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCG
TACACTCTGGAAGATCAGAACCGGGAATTCATGGTTTTCGCCCATGCTCAATGGAAAGCA
CAGGCACAAAGTATATTTTCTCTATTAATGAGTTCATCCAGTGGTTTTCTTGACTTATTT
TTTTCGCATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCAGTGTTTCTGGATCCTTTTGATACCTGTGGCTTAATTGTTGCTAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCACCAGGGGAATATTTTGCCGCCATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAATGATCTCTTAGGGTTCTCAGATGCC
ATGACTTTCAAGGAGAGAGTATGGAACCACATCGTGCACTTGGAGGACCATTTATTTTGC
CAGTATCTTTTAAGAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGTCACACATCAATTTGGTTGTTGCGAACGGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAACATGATCTTCATTGGTGGTATCAACTGTCATCAGGGA
AAGCCATTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_20_GenBank_ID_Gene:
U89508

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_20_Locus:
2q37

# Metabolic_Enzyme_20_SNPs:
Not Available

# Metabolic_Enzyme_20_General_References:
9271343; 11434514

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
5720

# Metabolic_Enzyme_21_Name:
UDP-glucuronosyltransferase 2B10 precursor

# Metabolic_Enzyme_21_Synonyms:
UDPGT

# Metabolic_Enzyme_21_Gene_Name:
UGT2B10

# Metabolic_Enzyme_21_Protein_Sequence:
>UDPglucuronosyltransferase 2B10 precursor
MALKWTTVLLIQLSFYFSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSAS
ILFDPNDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEILWAIND
IIRNFCKDVVSNKKLMKKLQESRFDIVFADAYLPCGELLAELFNIPFVYSHSFSPGYSFE
RHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWFQIFNMKKWDQFYSEVLG
RPTTLSETMRKADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGE
NGVVVFSLGSMVSNMTEERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQND
LLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMS
STDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAH
NLTWFQYHSLDVIGFLLACVATVLFIITKCCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_21_Number_of_Residues:
528

# Metabolic_Enzyme_21_Molecular_Weight:
60775

# Metabolic_Enzyme_21_Theoretical_pI:
9.40

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_21_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_21_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_21_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_21_Signals:
1-23

# Metabolic_Enzyme_21_Transmembrane_Regions:
492-512

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_21_GenBank_ID_Protein:
516150

# Metabolic_Enzyme_21_SwissProt_ID:
UDB10_HUMAN (P36537)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
UGT2B10

# Metabolic_Enzyme_21_Geneatlas_id:
UGT2B10

# Metabolic_Enzyme_21_hgnc_id:
HGNC:12544

# Metabolic_Enzyme_21_PDB_ID:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Microsome

# Metabolic_Enzyme_21_Gene_Sequence:
>1587 bp
ATGGCTCTGAAATGGACTACAGTTCTGCTGATACAACTCAGTTTTTACTTTAGCTCTGGG
AGTTGTGGAAAGGTGCTGGTATGGGCCGCAGAATACAGCCTTTGGATGAATATGAAGACA
ATCCTGAAAGAACTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCTTCC
ATTCTTTTTGATCCCAACGACTCATCCACTCTTAAACTTGAAGTTTATCCTACATCTTTA
ACTAAAACTGAATTTGAGAATATCATCATGCAATTGGTTAAGAGATTGTCAGAAATTCAA
AAAGATACATTTTGGTTACCTTTTTCACAAGAACAAGAAATCCTGTGGGCAATTAATGAC
ATAATTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAACTTATGAAAAAACTACAA
GAGTCAAGATTTGACATCGTTTTTGCAGATGCTTATTTACCCTGTGGTGAGCTGCTGGCT
GAGCTATTTAACATACCCTTTGTGTACAGTCACAGCTTCAGTCCTGGCTACTCATTTGAA
AGGCACAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAAAATTA
AGTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGCTCTATGTGCTTTATTTTGAC
TTTTGGTTCCAAATATTTAATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTAGGA
AGACCCACTACATTATCTGAGACAATGAGGAAAGCTGACATATGGCTTATGCGAAACTCC
TGGAATTTTAAATTTCCTCATCCATTCTTACCAAATGTTGATTTTGTTGGAGGACTCCAC
TGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAGTTTGTACAGAGCTCTGGAGAA
AATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGGGCC
AACGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTTTGGAGATTTGATGGG
AATAAACCAGATGCCTTAGGTCTCAATACTCGACTGTACAAGTGGATACCCCAGAATGAC
CTTCTAGGTCATCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATCTAT
GAGGCAATCTACCATGGGATCCCTATGGTGGGCATTCCATTGTTTTTTGATCAACCTGAT
AATATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGAGTGGACTTCAACACAATGTCG
AGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTCATATAAAGAGAAT
ATTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCAGTC
TTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCCAAACATCTTCGAGTTGCAGCCCAC
AACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGCTTGTGTG
GCAACCGTGCTATTTATCATCACAAAGTGTTGTCTGTTTTGTTTCTGGAAGTTTGCTAGA
AAAGGAAAGAAGGGAAAAAGGGATTAG

# Metabolic_Enzyme_21_GenBank_ID_Gene:
X63359

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_21_Locus:
4q13.2

# Metabolic_Enzyme_21_SNPs:
rs3208727; rs17146903; rs17146904; rs835313; rs835316; rs835309; rs861340; rs844342; rs1841042; rs294778; rs835311; rs2670431; rs294777; rs835317; rs7676529; rs835310; rs11726322; rs11249509; rs1968764; rs7676146; rs1849533; rs17146894; rs835314; rs294772; rs9917967; rs2054221; rs3792628; rs1849534; rs1913316; rs7657958; rs1913315; rs2926036; rs835312; rs1913317; rs4694343; rs835319; rs7673996; rs2670430; rs835315; rs4694344; rs1913318; rs7670334; rs1913320; rs11940320; rs294776; rs4694358; rs294775; rs1976666; rs4095564; rs9917968; rs2942857; rs4116824; rs3215212; rs28563143; rs1902931; rs13111730; rs12506094; rs1979281; rs11347207; rs34334121; rs12511664; rs5859144; rs5859145; rs13141448; rs4116823; rs28377589; rs35887929; rs36003814; rs34999460; rs7678703; rs9917930; rs35390620; rs1902932; rs7674011; rs6839369; rs10007687; rs4095563; rs5859146; rs1902930; rs13148664; rs33938096; rs13110924; rs5859147; rs7685333; rs28586884; rs10428371; rs294771; rs13132114; rs6839806; rs34291505; rs13131461; rs13132118; rs13114078; rs4116825; rs13111722; rs835318; rs17146905; rs34183546; rs35690388; rs11725502; rs35525464; rs11729424; rs11737566; rs11737644; rs1379809; rs1458232; rs1458233; rs294765; rs294770; rs4450999; rs4694340; rs6816491; rs6836993; rs6843220

# Metabolic_Enzyme_21_General_References:
8333863

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
6128

# Metabolic_Enzyme_22_Name:
Estradiol 17-beta-dehydrogenase 1

# Metabolic_Enzyme_22_Synonyms:
17-beta- hydroxysteroid dehydrogenase type 1; 17-beta-HSD 1; Placental 17- beta-hydroxysteroid dehydrogenase; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH

# Metabolic_Enzyme_22_Gene_Name:
HSD17B1

# Metabolic_Enzyme_22_Protein_Sequence:
>Estradiol 17betadehydrogenase 1
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL
ETLQLDVRDS
KSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGT
VRMLQAFLPDMKRRGSGRVLV
TGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG
VHLSLIECGPVHTAFMEKVLGSPEEVLDRTDI
HTFHRFYQYLAHSKQVFREAAQNPEEV
AEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAM
HREVFGDVPAKAEAGA
EAGGGAGPGAEDEAGRSAVGDPELGDPPAAPQ

# Metabolic_Enzyme_22_Number_of_Residues:
328

# Metabolic_Enzyme_22_Molecular_Weight:
34980

# Metabolic_Enzyme_22_Theoretical_pI:
5.42

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  estradiol 17-beta-dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
Process:  estrogen biosynthesis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_22_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_22_Specific_Function:
Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH

# Metabolic_Enzyme_22_Pathway:
map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_22_Reaction:
estradiol-17beta + NAD(P)+ = estrone + NAD(P)H + H+

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_22_Signals:
1-30

# Metabolic_Enzyme_22_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 1.1.1.62

# Metabolic_Enzyme_22_GenBank_ID_Protein:
23365

# Metabolic_Enzyme_22_SwissProt_ID:
DHB1_HUMAN (P14061)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
HSD17B1

# Metabolic_Enzyme_22_Geneatlas_id:
HSD17B1

# Metabolic_Enzyme_22_hgnc_id:
HGNC:5210

# Metabolic_Enzyme_22_PDB_ID:
1QYX

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_22_Gene_Sequence:
>987 bp

ATGGCCCGCACCGTGGTGCTCATCACCGGCTGTTCCTCGGGCATCGGCCTGCACTTGGC
CGTACGTCTGG
CTTCAGATCCATCCCAGAGCTTCAAAGTGTATGCCACGTTGAGGGACC
TGAAAACACAGGGCCGGCTGTG
GGAGGCGGCCCGGGCCCTGGCATGCCCTCCGGGATCC
CTGGAGACGTTGCAGCTGGACGTAAGGGACTCA
AAATCCGTGGCCGCTGCCCGGGAACG
CGTGACTGAGGGCCGCGTGGACGTGCTGGTGTGTAACGCAGGCC
TGGGCCTGCTGGGGC
CGCTGGAGGCGCTGGGGGAGGACGCCGTGGCCTCTGTGCTGGACGTGAATGTAGT
AGGG
ACTGTGCGGATGCTGCAGGCCTTCCTGCCAGACATGAAGAGGCGCGGTTCGGGACGCGTG
TTGGTG
ACCGGGAGCGTGGGAGGATTGATGGGGCTGCCTTTCAATGACGTTTATTGCGC
CAGCAAGTTCGCGCTCG
AAGGCTTATGCGAGAGTCTGGCGGTTCTGCTGCTGCCCTTTG
GGGTCCACTTGAGCCTGATCGAGTGCGG
CCCAGTGCACACCGCCTTCATGGAGAAGGTG
TTGGGCAGCCCAGAGGAGGTGCTGGACCGCACGGACATC
CACACCTTCCACCGCTTCTA
CCAATACCTCGCCCACAGCAAGCAAGTCTTTCGCGAGGCGGCGCAGAACC
CTGAGGAGG
TGGCGGAGGTCTTCCTCACCGCTTTGCGCGCCCCGAAGCCGACCCTGCGCTACTTCACCA
C
CGAGCGCTTCCTGCCCCTGCTGCGGATGCGCCTGGACGACCCCAGCGGCTCCAACTAC
GTCACCGCCATG
CACCGGGAAGTGTTCGGCGACGTTCCGGCAAAGGCCGAGGCTGGGGC
CGAGGCTGGGGGCGGGGCCGGGC
CTGGGGCAGAGGACGAGGCCGGGCGCAGTGCGGTGG
GGGACCCTGAGCTCGGCGATCCTCCGGCCGCCCC
GCAGTAA

# Metabolic_Enzyme_22_GenBank_ID_Gene:
X13440

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_22_Locus:
17q11-q21

# Metabolic_Enzyme_22_SNPs:
rs605059; rs12945667; rs2830; rs2229233; rs2676531; rs597255; rs610166; rs2676530; rs610177; rs676387; rs592389; rs670452; rs470842; rs9915824; rs470885; rs28490403; rs1051381; rs28722471; rs2676532; rs6413434; rs35099842; rs10153; rs675733; rs2854974; rs470904; rs2855481; rs2855482; rs35545131; rs1048170; rs1048178; rs12602084; rs16967862; rs2301132; rs2854977; rs2854978; rs2855484; rs3177667; rs3752386; rs598126; rs607740; rs607795; rs615942; rs621141; rs629861; rs666039; rs668799; rs7219522

# Metabolic_Enzyme_22_General_References:
2846351; 2779584; 2330005; 2197970; 1327779; 5045524; 4719204; 3955020; 6578212; 2547159; 7663947; 8805577; 9525918; 10625652; 8389226

# Metabolic_Enzyme_22_References:
Not Available

# Metabolic_Enzyme_23_ID:
5560

# Metabolic_Enzyme_23_Name:
Arylsulfatase E precursor

# Metabolic_Enzyme_23_Synonyms:
ASE

# Metabolic_Enzyme_23_Gene_Name:
ARSE

# Metabolic_Enzyme_23_Protein_Sequence:
>Arylsulfatase E precursor
MLHLHHSCLCFRSWLPAMLAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNT
MRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASG
GLPTNETTFAKILKEKGYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGD
CARWELSEKRVNLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLAS
SYFVGALIVHADCFLMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHV
HIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLEN
QLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVR
LAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFV
TPVFQPEGAGACYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHILTPASEPVFYQVMER
VQQAVWEHQRTLSPVPLQLDRLGNIWRPWLQPCCGPFPLCWCLREDDPQ

# Metabolic_Enzyme_23_Number_of_Residues:
589

# Metabolic_Enzyme_23_Molecular_Weight:
65670

# Metabolic_Enzyme_23_Theoretical_pI:
6.96

# Metabolic_Enzyme_23_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  sulfuric ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_23_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_23_Specific_Function:
May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates

# Metabolic_Enzyme_23_Pathway:
Not Available

# Metabolic_Enzyme_23_Reaction:
Not Available

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF00884:Sulfatase

# Metabolic_Enzyme_23_Signals:
1-31

# Metabolic_Enzyme_23_Transmembrane_Regions:
200-222; 227-249; 289-311

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 3.1.6.1

# Metabolic_Enzyme_23_GenBank_ID_Protein:
791004

# Metabolic_Enzyme_23_SwissProt_ID:
ARSE_HUMAN (P51690)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
ARSE

# Metabolic_Enzyme_23_Geneatlas_id:
ARSE

# Metabolic_Enzyme_23_hgnc_id:
HGNC:719

# Metabolic_Enzyme_23_PDB_ID:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Golgi apparatus; Golgi stack

# Metabolic_Enzyme_23_Gene_Sequence:
>1770 bp
ATGTTACATCTGCACCATTCTTGTTTGTGTTTCAGGAGCTGGCTGCCAGCGATGCTCGCT
GTACTGCTAAGTTTGGCACCATCAGCTTCCAGCGACATTTCCGCCTCCCGACCGAACATC
CTTCTTCTGATGGCGGACGACCTTGGCATTGGGGACATTGGCTGCTATGGCAACAACACC
ATGAGGACTCCGAATATTGACCGCCTTGCAGAGGACGGCGTGAAGCTGACCCAACACATC
TCTGCCGCATCTTTGTGCACCCCAAGCAGAGCCGCCTTCCTCACGGGCAGATACCCTGTG
CGATCAGGGATGGTTTCCAGCATTGGTTACCGTGTTCTTCAGTGGACCGGAGCATCTGGA
GGTCTTCCAACAAATGAGACAACTTTTGCAAAAATACTGAAAGAGAAAGGCTATGCCACT
GGACTCATTGGAAAATGGCATCTGGGTCTCAACTGTGAGTCAGCCAGTGATCATTGCCAC
CACCCTCTCCATCATGGCTTTGAGCATTTCTACGGAATGCCTTTCTCCTTGATGGGTGAT
TGCGCCCGCTGGGAACTCTCAGAGAAGCGTGTCAACCTGGAACAAAAACTCAACTTCCTC
TTCCAAGTCCTGGCCTTGGTTGCCCTCACACTGGTAGCAGGGAAGCTCACACACCTGATA
CCCGTCTCGTGGATGCCGGTCATCTGGTCAGCCCTTTCGGCCGTCCTCCTCCTCGCAAGC
TCCTATTTTGTGGGTGCTCTGATTGTCCATGCCGATTGCTTTCTGATGAGAAACCACACC
ATCACGGAGCAGCCCATGTGCTTCCAAAGAACGACACCCCTTATTCTGCAGGAGGTTGCG
TCCTTTCTCAAAAGGAATAAGCATGGGCCTTTCCTCCTCTTTGTTTCCTTTCTACACGTT
CACATCCCTCTTATCACTATGGAGAACTTCCTCGGGAAGAGTCTCCACGGGCTGTATGGG
GACAACGTAGAGGAGATGGACTGGATGGTAGGACGGATCCTTGACACTTTGGACGTGGAG
GGTTTGAGCAACAGCACCCTCATTTATTTTACGTCGGATCACGGCGGTTCCCTAGAGAAT
CAACTTGGAAACACCCAGTATGGTGGCTGGAATGGAATTTATAAAGGTGGGAAGGGCATG
GGAGGATGGGAAGGTGGGATCCGCGTGCCCGGGATCTTCCGCTGGCCCGGGGTGCTCCCG
GCCGGCCGAGTGATTGGCGAGCCCACGAGTCTGATGGACGTGTTCCCCACCGTGGTCCGG
CTGGCGGGCGGCGAGGTGCCCCAGGACAGAGTGATTGACGGCCAAGACCTTCTGCCCTTG
CTCCTGGGGACAGCCCAACACTCAGACCACGAGTTCCTGATGCATTATTGTGAGAGGTTT
CTGCACGCAGCCAGGTGGCATCAACGGGACAGAGGAACAATGTGGAAAGTCCACTTTGTG
ACGCCTGTGTTCCAGCCAGAGGGAGCCGGTGCCTGCTATGGAAGAAAGGTCTGCCCGTGC
TTTGGGGAAAAAGTAGTCCACCACGATCCACCTTTGCTCTTTGACCTCTCAAGAGACCCT
TCTGAGACCCACATCCTCACACCAGCCTCAGAGCCCGTGTTCTATCAGGTGATGGAACGA
GTCCAGCAGGCGGTGTGGGAACACCAGCGGACACTCAGCCCAGTTCCTCTGCAGCTGGAC
AGGCTGGGCAACATCTGGAGACCGTGGCTGCAGCCCTGCTGTGGCCCGTTCCCCCTCTGC
TGGTGCCTTAGGGAAGATGACCCACAATAA

# Metabolic_Enzyme_23_GenBank_ID_Gene:
X83573

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_23_Locus:
Xp22.3

# Metabolic_Enzyme_23_SNPs:
rs34412194; rs35143646; rs11222; rs17325750; rs11055; rs35718384; rs1875647; rs176994; rs12687057; rs211644; rs211640; rs190023; rs211646; rs211639; rs11798027; rs1972528; rs1985082; rs2302079; rs4892825; rs211641; rs6641673; rs4892828; rs211636; rs4892827; rs11797823; rs12847525; rs211642; rs169828; rs4892826; rs211638; rs211645; rs5982928; rs4892910; rs12392879; rs12690163; rs4892909; rs211637; rs5982944; rs5982926; rs5982947; rs5982948; rs41310272; rs28935474; rs5982618; rs41308353; rs2302078; rs35274634; rs34795651; rs11386125; rs35172906; rs5982943; rs35727588; rs5982621; rs35930766; rs5982942; rs5982620; rs5982619; rs5982941; rs12862274; rs34368774; rs12014203; rs5982937; rs12842633; rs35373572; rs1985083; rs35557443; rs12841888; rs7055850; rs12852998; rs6642073; rs34095951; rs28695378; rs11439303; rs6641671; rs7877827; rs191925; rs12845799; rs5982940; rs6642075; rs5982929; rs5982933; rs12841639; rs12690083; rs5982930; rs2238847; rs6642074; rs5982932; rs12853008; rs12847404; rs211643; rs12836850; rs12853316; rs36060128; rs35703084; rs5982939; rs7881434; rs12841616; rs35328022; rs3216370; rs6642076; rs12853583; rs35961426; rs12394933; rs3753140; rs28520254; rs5982938; rs12842105; rs5982931; rs1972527; rs12847425; rs3753141; rs12845808; rs183318; rs12852742; rs34854714; rs35592318; rs12388707; rs41309659; rs28602557; rs6642071; rs28678263; rs5982945; rs28545096; rs34081519; rs5982946; rs5982927; rs11152554; rs12393627; rs12852717; rs2302077; rs3747393; rs3747394; rs3747395; rs3747396; rs3827454; rs5982955

# Metabolic_Enzyme_23_General_References:
7720070; 9497243; 9409863

# Metabolic_Enzyme_23_References:
Not Available

# Metabolic_Enzyme_24_ID:
5726

# Metabolic_Enzyme_24_Name:
UDP-glucuronosyltransferase 1-9 precursor

# Metabolic_Enzyme_24_Synonyms:
UDP- glucuronosyltransferase 1A9; UDPGT; UGT1*9; UGT1-9; UGT1.9; UGT- 1I; UGT1I; lugP4

# Metabolic_Enzyme_24_Gene_Name:
UGT1A9

# Metabolic_Enzyme_24_Protein_Sequence:
>UDPglucuronosyltransferase 19 precursor
MACTGWTSPLPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMRSVVEKLILRGHEVVVVMP
EVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLF
FSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNCGLIVAKYFSLPSVVFARGILCHYLEEG
AQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLLCHRFFKNALEIASEILQTPVT
EYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_24_Number_of_Residues:
530

# Metabolic_Enzyme_24_Molecular_Weight:
59942

# Metabolic_Enzyme_24_Theoretical_pI:
7.96

# Metabolic_Enzyme_24_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_24_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_24_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols

# Metabolic_Enzyme_24_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_24_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_24_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_24_Signals:
1-25

# Metabolic_Enzyme_24_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_24_GenBank_ID_Protein:
7690346

# Metabolic_Enzyme_24_SwissProt_ID:
UD19_HUMAN (O60656)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
UGT1A9

# Metabolic_Enzyme_24_Geneatlas_id:
UGT1A9

# Metabolic_Enzyme_24_hgnc_id:
HGNC:12541

# Metabolic_Enzyme_24_PDB_ID:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Microsome

# Metabolic_Enzyme_24_Gene_Sequence:
>1593 bp
ATGGCTTGCACAGGGTGGACCAGCCCCCTTCCTCTATGTGTGTGTCTGCTGCTGACCTGT
GGCTTTGCCGAGGCAGGGAAGCTAGTGGTAGTGCCCATGGATGGGAGCCACTGGTTCACC
ATGAGGTCGGTGGTGGAGAAACTCATTCTCAGGGGGCATGAGGTGGTTGTAGTCAGTGCC
AGAGGTGAGTTGGCAACTGGGAAGATCAATGAATTGCACAGTGAAGACTTATTCAACTTC
ATATACCTGGAGGATCTGGACCGGGAGTTCAAGGCTTTTGCCCATGCTCAATGGAAAGCA
CAAGTACGAAGTATATATTCTCTATTAATGGGTTCATACAATGACATTTTTGACTTATTT
TTTTCAAATTGCAGGAGTTTGTTTAAAGACAAAAAATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCAGTGTTTCTCGATCCTTTTGATAACTGTGGCTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCCGTGGTCTTCGCCAGGGGAATACTTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGAATTCTCTTAGGGTTCTCAGATGAC
ATGACTTTCAAGGAGAGAGTACGGAACCACATCATGCACTTGGAGGAACATTTATTATGC
CACCGTTTTTTCAAAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACACCTGTTACG
GAGTATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACGGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAACATGATCTTCATTGGTGGTATCAACTGCCATGAGAGG
AAAGCGTTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GGTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATGC
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCAGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCATGAATGTTCTGGAAATGACTTCTGAAGAATTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTTATGAGGCACAAGGGCGCGACACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGCCGTGCTGACAGTGGCC
TTCATCACCTGTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_24_GenBank_ID_Gene:
S55985

# Metabolic_Enzyme_24_Chromosome_Location:
Not Available

# Metabolic_Enzyme_24_Locus:
Not Available

# Metabolic_Enzyme_24_SNPs:
Not Available

# Metabolic_Enzyme_24_General_References:
1910331; 11434514

# Metabolic_Enzyme_24_References:
Not Available

# Metabolic_Enzyme_25_ID:
5691

# Metabolic_Enzyme_25_Name:
Estradiol 17-beta-dehydrogenase 8

# Metabolic_Enzyme_25_Synonyms:
17-beta-HSD 8; 17- beta-hydroxysteroid dehydrogenase 8; Protein Ke6; Ke-6

# Metabolic_Enzyme_25_Gene_Name:
HSD17B8

# Metabolic_Enzyme_25_Protein_Sequence:
>Estradiol 17betadehydrogenase 8
MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGS
KEGPPRGNHA
AFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDD
WDKVIAVNLKGTFLVTQAAAQ
ALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIG
LTQTAARELGRHGIRCNSVLPGFIATPMTQKV
PQKVVDKITEMIPMGHLGDPEDVADVV
AFLASEDSGYITGTSVEVTGGLFM

# Metabolic_Enzyme_25_Number_of_Residues:
261

# Metabolic_Enzyme_25_Molecular_Weight:
26974

# Metabolic_Enzyme_25_Theoretical_pI:
6.50

# Metabolic_Enzyme_25_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_25_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_25_Specific_Function:
Uses estradiol as its preferred substrate

# Metabolic_Enzyme_25_Pathway:
map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_25_Reaction:
estradiol-17beta + NAD(P)+ = estrone + NAD(P)H + H+

# Metabolic_Enzyme_25_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_25_Signals:
None

# Metabolic_Enzyme_25_Transmembrane_Regions:
None

# Metabolic_Enzyme_25_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_25_EC_Link:
EC 1.1.1.62

# Metabolic_Enzyme_25_GenBank_ID_Protein:
30583317

# Metabolic_Enzyme_25_SwissProt_ID:
DHB8_HUMAN (Q92506)

# Metabolic_Enzyme_25_swissprot_Name:
Not Available

# Metabolic_Enzyme_25_Genecard_id:
HSD17B8

# Metabolic_Enzyme_25_Geneatlas_id:
HSD17B8

# Metabolic_Enzyme_25_hgnc_id:
HGNC:3554

# Metabolic_Enzyme_25_PDB_ID:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_25_Subcellular_Location:
Not Available

# Metabolic_Enzyme_25_Gene_Sequence:
>786 bp

ATGGCGTCTCAGCTCCAGAACCGACTCCGCTCCGCACTGGCCTTGGTCACAGGTGCGGG
GAGCGGCATCG
GCCGAGCGGTCAGTGTACGCCTGGCCGGAGAGGGGGCCACCGTAGCTG
CCTGCGACCTGGACCGGGCAGC
GGCACAGGAGACGGTGCGGCTGCTGGGCGGGCCAGGG
AGCAAGGAGGGGCCGCCCCGAGGGAACCATGCT
GCCTTCCAGGCTGACGTGTCTGAGGC
CAGGGCCGCCAGGTGCCTGCTGGAACAAGTGCAGGCCTGCTTTT
CTCGCCCACCATCTG
TCGTTGTGTCCTGTGCGGGCATCACCCAGGATGAGTTTCTGCTGCACATGTCTGA
GGAT
GACTGGGACAAAGTCATAGCTGTCAACCTCAAGGGCACCTTCCTAGTCACTCAGGCTGCA
GCACAA
GCCCTGGTGTCCAATGGTTGTCGTGGTTCCATCATCAACATCAGTAGCATCGT
AGGAAAGGTGGGGAACG
TGGGGCAGACAAACTATGCAGCATCCAAGGCTGGAGTGATTG
GGCTGACCCAGACCGCAGCCCGGGAGCT
TGGACGACATGGGATCCGCTGTAACTCTGTC
CTCCCAGGGTTCATTGCAACACCCATGACACAGAAAGTG
CCACAGAAAGTGGTGGACAA
GATTACTGAAATGATCCCGATGGGACACTTGGGGGACCCTGAGGATGTGG
CAGATGTGG
TCGCATTCTTGGCATCTGAAGATAGTGGATACATCACAGGGACCTCAGTGGAAGTCACTG
G
AGGTCTTTTCATGTAG

# Metabolic_Enzyme_25_GenBank_ID_Gene:
BT007239

# Metabolic_Enzyme_25_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_25_Locus:
6p21.3

# Metabolic_Enzyme_25_SNPs:
Not Available

# Metabolic_Enzyme_25_General_References:
14574404; 8812499

# Metabolic_Enzyme_25_References:
Not Available

# Metabolic_Enzyme_26_ID:
5551

# Metabolic_Enzyme_26_Name:
Arylsulfatase D precursor

# Metabolic_Enzyme_26_Synonyms:
ASD

# Metabolic_Enzyme_26_Gene_Name:
ARSD

# Metabolic_Enzyme_26_Protein_Sequence:
>Arylsulfatase D precursor
MRSAARRGRAAPAARDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYG
NNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNA
GSGGLPENETTFARILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTL
TNDCDPGRPPEVDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLF
FISWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSL
LHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGH
LEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPT
VVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQKDSGSVWKV
HYTTPQFHPEERGLLTAEASAHAEWGGVTHHRPPLLFDLSRDPSEARPLTPDSEPLYHAV
IARVGAAVSEHRQTLSPVPQQFSMSNILWKPWLQPCCGHFPFCSCHEDGDGTP

# Metabolic_Enzyme_26_Number_of_Residues:
593

# Metabolic_Enzyme_26_Molecular_Weight:
65072

# Metabolic_Enzyme_26_Theoretical_pI:
7.10

# Metabolic_Enzyme_26_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  sulfuric ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_26_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_26_Specific_Function:
Not Available

# Metabolic_Enzyme_26_Pathway:
Not Available

# Metabolic_Enzyme_26_Reaction:
Not Available

# Metabolic_Enzyme_26_Pfam_Domain_Function:
PF00884:Sulfatase

# Metabolic_Enzyme_26_Signals:
1-33

# Metabolic_Enzyme_26_Transmembrane_Regions:
206-225; 229-251; 292-314

# Metabolic_Enzyme_26_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_26_EC_Link:
EC 3.1.6.1

# Metabolic_Enzyme_26_GenBank_ID_Protein:
791002

# Metabolic_Enzyme_26_SwissProt_ID:
ARSD_HUMAN (P51689)

# Metabolic_Enzyme_26_swissprot_Name:
Not Available

# Metabolic_Enzyme_26_Genecard_id:
ARSD

# Metabolic_Enzyme_26_Geneatlas_id:
ARSD

# Metabolic_Enzyme_26_hgnc_id:
HGNC:717

# Metabolic_Enzyme_26_PDB_ID:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_26_Subcellular_Location:
Lysosome (Potential)

# Metabolic_Enzyme_26_Gene_Sequence:
>1782 bp
ATGCGATCCGCCGCGCGGAGGGGACGCGCCGCGCCCGCCGCCAGGGACTCTTTGCCGGTG
CTACTGTTTTTATGCTTGCTTCTGAAGACGTGTGAACCTAAAACTGCAAATGCCTTTAAA
CCAAATATCCTACTGATCATGGCGGATGATCTAGGCACTGGGGATCTCGGTTGCTACGGG
AACAATACACTGAGAACGCCGAATATTGACCAGCTTGCAGAGGAAGGTGTGAGGCTCACT
CAGCACCTGGCGGCCGCCCCGCTCTGCACCCCAAGCCGAGCTGCATTCCTCACAGGGAGA
CATTCCTTCAGATCAGGCATGGACGCCAGCAATGGATACCGGGCCCTTCAGTGGAACGCA
GGCTCAGGTGGACTCCCTGAGAACGAAACCACTTTTGCAAGAATCTTGCAGCAGCATGGC
TATGCAACCGGCCTCATAGGAAAATGGCACCAGGGTGTGAATTGTGCATCCCGCGGGGAT
CACTGCCACCACCCCCTGAACCACGGATTTGACTATTTCTACGGCATGCCCTTCACGCTC
ACAAACGACTGTGACCCAGGCAGGCCCCCCGAAGTGGACGCCGCCCTGAGGGCGCAGCTC
TGGGGTTACACCCAGTTCCTGGCGCTGGGGATTCTCACCCTGGCTGCCGGCCAGACCTGC
GGTTTCTTCTCTGTCTCCGCGAGAGCAGTCACCGGCATGGCCGGCGTGGGCTGCCTGTTT
TTCATCTCTTGGTACTCCTCCTTCGGGTTTGTGCGACGCTGGAACTGTATCCTGATGAGA
AACCATGACGTCACGGAGCAACCCATGGTTCTGGAGAAAACAGCGAGTCTTATGCTAAAG
GAAGCTGTTTCCTATATTGAAAGACACAAGCATGGGCCATTTCTCCTCTTCCTTTCTTTG
CTGCATGTGCACATTCCCCTTGTGACCACGAGTGCATTCCTGGGGAAAAGTCAGCATGGC
TTATATGGTGATAATGTGGAGGAGATGGACTGGCTCATAGGTAAGGTTCTTAATGCCATC
GAAGACAATGGTTTAAAGAACTCAACATTCACGTATTTCACCTCTGACCATGGAGGACAT
TTAGAGGCAAGAGATGGACACAGCCAGTTAGGGGGATGGAACGGAATTTACAAAGGTGGG
AAGGGCATGGGAGGATGGGAAGGTGGGATCCGAGTGCCCGGGATCTTCCACTGGCCGGGG
GTGCTCCCGGCCGGCCGAGTGATTGGAGAGCCCACGAGCCTGATGGACGTGTTCCCTACT
GTGGTCCAGCTGGTGGGTGGCGAGGTGCCCCAGGACAGGGTGATTGATGGCCACAGCCTG
GTACCCTTGCTGCAGGGAGCTGAGGCACGCTCGGCACATGAGTTCCTGTTTCATTACTGT
GGGCAGCATCTTCACGCAGCACGCTGGCACCAGAAGGACAGTGGAAGCGTCTGGAAGGTT
CATTACACGACCCCGCAGTTCCACCCCGAGGAGCGGGGCCTGCTAACGGCCGAGGCGTCT
GCCCATGCTGAATGGGGAGGCGTGACCCATCACAGACCCCCTTTGCTCTTTGACCTCTCC
AGGGACCCCTCCGAGGCACGGCCCCTGACCCCCGACTCCGAGCCCCTGTACCACGCCGTG
ATAGCAAGGGTAGGTGCCGCGGTGTCGGAGCATCGGCAGACCCTGAGTCCTGTGCCCCAG
CAGTTTTCCATGAGCAACATCCTGTGGAAGCCGTGGCTGCAGCCGTGCTGCGGACATTTC
CCGTTCTGTTCATGCCACGAGGATGGGGATGGCACCCCCTGA

# Metabolic_Enzyme_26_GenBank_ID_Gene:
X83572

# Metabolic_Enzyme_26_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_26_Locus:
Xp22.3

# Metabolic_Enzyme_26_SNPs:
rs211653; rs211648; rs2228431; rs34494682; rs2229557; rs2228433; rs35096299; rs2302076; rs9334; rs211647; rs5939146; rs5939392; rs12388793; rs7884079; rs1043269; rs1043270; rs17331014; rs1043272; rs211649; rs12846104; rs5982920; rs6642066; rs4892908; rs2302077; rs5939397; rs1637781; rs1637779; rs1637777; rs12013334; rs4892907; rs6642067; rs1637776; rs3747394; rs5939398; rs3747393; rs1124546; rs5939399; rs5982919; rs5982617; rs211651; rs5939400; rs3747395; rs5982616; rs3827454; rs5982916; rs6567682; rs5982609; rs5982610; rs3747397; rs5982611; rs4141210; rs17335121; rs4141211; rs41302629; rs41311465; rs41302625; rs5939391; rs11538097; rs1138618; rs11556962; rs5982917; rs34210921; rs1138619; rs10634744; rs3078565; rs3747396; rs10218035; rs11556963; rs5982922; rs35837588; rs10555820; rs34910956; rs41308439; rs5982615; rs5939395; rs7053429; rs7065372; rs5982921; rs169829; rs11403125; rs34925283; rs5939147; rs10555819; rs12836012; rs35033726; rs1847214; rs211650; rs5939396; rs5982614; rs1698812; rs28587311; rs41297279; rs10624089; rs6642068; rs1637774; rs1627688; rs188430; rs34494989; rs5939148; rs7357997; rs211652; rs5982613; rs1502873; rs41302607; rs5939393; rs5982923; rs186112; rs5982918; rs4451470; rs1637780; rs1637778; rs10624690; rs34368255; rs5939401; rs1698814; rs41310266; rs35787994; rs5982914; rs7884701; rs35372805; rs7889616; rs3833415; rs7884791; rs7053284; rs5982915; rs11152554; rs12852742; rs5982606; rs5982911

# Metabolic_Enzyme_26_General_References:
7720070; 11177574

# Metabolic_Enzyme_26_References:
Not Available

# Metabolic_Enzyme_27_ID:
6129

# Metabolic_Enzyme_27_Name:
3-keto-steroid reductase

# Metabolic_Enzyme_27_Synonyms:
Estradiol 17-beta- dehydrogenase 7; 17-beta-HSD 7; 17-beta-hydroxysteroid dehydrogenase 7

# Metabolic_Enzyme_27_Gene_Name:
HSD17B7

# Metabolic_Enzyme_27_Protein_Sequence:
>3ketosteroid reductase
MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIV
QVDVSNLQSV
FRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFST
AEGLLTQGDKITADGLQEVFE
TNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSN
FSLEDFQHSKGKEPYSSSKYATDLLSVALNRN
FNQQGLYSNVACPGTALTNLTYGILPP
FIWTLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLN
PLIKYLSATTGFGRNY
IMTQKMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL

# Metabolic_Enzyme_27_Number_of_Residues:
341

# Metabolic_Enzyme_27_Molecular_Weight:
38207

# Metabolic_Enzyme_27_Theoretical_pI:
8.21

# Metabolic_Enzyme_27_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_27_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_27_Specific_Function:
Responsible for the reduction of the keto group on the C-3 of sterols

# Metabolic_Enzyme_27_Pathway:
map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_27_Reaction:
4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP+ = 4alpha-methyl-5alpha-cholest-7-en-3-one + NADPH + H+

# Metabolic_Enzyme_27_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_27_Signals:
1-19

# Metabolic_Enzyme_27_Transmembrane_Regions:
230-250

# Metabolic_Enzyme_27_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_27_EC_Link:
EC 1.1.1.270;EC 1.1.1.62

# Metabolic_Enzyme_27_GenBank_ID_Protein:
6721095

# Metabolic_Enzyme_27_SwissProt_ID:
DHB7_HUMAN (P56937)

# Metabolic_Enzyme_27_swissprot_Name:
Not Available

# Metabolic_Enzyme_27_Genecard_id:
HSD17B7

# Metabolic_Enzyme_27_Geneatlas_id:
HSD17B7

# Metabolic_Enzyme_27_hgnc_id:
HGNC:5215

# Metabolic_Enzyme_27_PDB_ID:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_27_Subcellular_Location:
Membrane; single-pass membrane protein

# Metabolic_Enzyme_27_Gene_Sequence:
>1026 bp

ATGCGAAAGGTGGTTTTGATCACCGGGGCTAGCAGTGGCATTGGCCTGGCCCTCTGCAA
GCGGCTGCTGG
CGGAAGATGATGAGCTTCATCTGTGTTTGGCGTGCAGGAACATGAGCA
AGGCAGAAGCTGTCTGTGCTGC
TCTGCTGGCCTCTCACCCCACTGCTGAGGTCACCATT
GTCCAGGTGGATGTCAGCAACCTGCAGTCGGTC
TTCCGGGCCTCCAAGGAACTTAAGCA
AAGGTTTCAGAGATTAGACTGTATATATCTAAATGCTGGGATCA
TGCCTAATCCACAAC
TAAATATCAAAGCACTTTTCTTTGGCCTCTTTTCAAGAAAAGTGATTCATATGTT
CTCC
ACAGCTGAAGGCCTGCTGACCCAGGGTGATAAGATCACTGCTGATGGACTTCAGGAGGTG
TTTGAG
ACCAATGTCTTTGGCCATTTTATCCTGATTCGGGAACTGGAGCCTCTCCTCTG
TCACAGTGACAATCCAT
CTCAGCTCATCTGGACATCATCTCGCAGTGCAAGGAAATCTA
ATTTCAGCCTCGAGGACTTCCAGCACAG
CAAAGGCAAGGAACCCTACAGCTCTTCCAAA
TATGCCACTGACCTTTTGAGTGTGGCTTTGAACAGGAAC
TTCAACCAGCAGGGTCTCTA
TTCCAATGTGGCCTGTCCAGGTACAGCATTGACCAATTTGACATATGGAA
TTCTGCCTC
CGTTTATATGGACGCTGTTGATGCCGGCAATATTGCTACTTCGCTTTTTTGCAAATGCAT
T
CACTTTGACACCATATAATGGAACAGAAGCTCTGGTATGGCTTTTCCACCAAAAGCCT
GAATCTCTCAAT
CCTCTGATCAAATATCTGAGTGCCACCACTGGCTTTGGAAGAAATTA
TATTATGACCCAGAAGATGGACC
TAGATGAAGACACTGCTGAAAAATTTTATCAAAAGT
TACTGGAACTGGAAAAGCACATTAGGGTCACTAT
TCAAAAAACAGATAATCAGGCCAGG
CTCAGTGGCTCATGCCTATAA

# Metabolic_Enzyme_27_GenBank_ID_Gene:
AF098786

# Metabolic_Enzyme_27_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_27_Locus:
1q23

# Metabolic_Enzyme_27_SNPs:
rs1704754; rs1780010; rs1780019; rs2805053; rs1039874; rs10917598; rs4656381; rs2997871; rs1964714; rs1704753; rs2996587; rs1780012; rs1704752; rs1892125; rs2997870; rs2491094; rs2457597; rs2805056; rs9786956; rs12402864; rs11589262; rs10917597; rs2684881; rs9663079; rs2457593; rs9427412; rs1780018; rs7529094; rs2262154; rs11581847; rs7530544; rs3215683; rs1704760; rs2684877; rs7538367; rs2998105; rs11577831; rs9661994; rs2490798; rs1780011; rs1704755; rs2983957; rs2457601; rs2684875; rs2257864; rs2998104; rs2257578; rs2947613; rs12563263; rs2457624; rs12118590; rs1137574; rs2805052; rs1137576; rs1060464; rs1060466; rs1137575; rs2996593; rs2997363; rs2257867; rs4038285; rs2803853; rs41271993; rs2803875; rs2457620; rs28407183; rs2997636; rs28496676; rs2947612; rs2457623; rs2257753; rs2997868; rs4038282; rs12061476; rs4146687; rs1780017; rs28658433; rs2257574; rs2457594; rs2258232; rs12027467; rs2665498; rs2997637; rs35444310; rs2491089; rs2490878; rs34036280; rs35058037; rs4038266; rs2997633; rs12026208; rs2457588; rs2461259; rs2457622; rs2997366; rs34321369; rs28786082; rs4038286; rs2684884; rs2257752; rs4038263; rs2261522; rs28838384; rs4657230; rs2997638; rs2490873; rs28836851; rs2805055; rs2997360; rs2803882; rs4038268; rs2997866; rs28757377; rs35057012; rs11576487; rs2941411; rs4038267; rs2457587; rs2258219; rs2490877; rs11581908; rs2457621; rs2490874; rs34894082; rs12067455; rs2457595; rs2490797; rs4387160; rs2997365; rs4146688; rs7527982; rs35961178; rs34770807; rs2264620; rs2997865; rs2805054; rs4038264; rs2461258; rs2457596; rs2997361; rs2257594; rs2490880; rs2997634; rs11590943; rs2457598; rs1780013; rs12041044; rs2258222; rs1704751; rs11587814; rs34522457; rs2490876; rs2490875; rs2257597; rs4038284; rs2457619; rs2457589; rs2461257; rs2996594; rs2261528; rs2997635; rs2257866; rs4095366; rs2997867; rs28837117; rs4038265; rs4084040; rs2258297; rs2490879; rs28494776; rs2257588; rs6670180; rs2997872; rs2997869; rs2457615; rs2997364; rs2457603; rs2457607; rs2997632; rs2457600; rs2457604; rs2457608; rs2457609; rs2457602; rs1626296; rs2457599; rs2805051; rs2457605; rs2457606; rs2491090; rs12085483; rs12736939; rs1622198; rs1780000; rs2457633; rs2457635; rs2457636; rs2803872

# Metabolic_Enzyme_27_General_References:
10544267; 12975309; 12829805

# Metabolic_Enzyme_27_References:
Not Available

# Metabolic_Enzyme_28_ID:
6851

# Metabolic_Enzyme_28_Name:
Cytochrome P450 1A1

# Metabolic_Enzyme_28_Synonyms:
CYPIA1; P450-P1; P450 form 6; P450-C

# Metabolic_Enzyme_28_Gene_Name:
CYP1A1

# Metabolic_Enzyme_28_Protein_Sequence:
>Cytochrome P450 1A1
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS

# Metabolic_Enzyme_28_Number_of_Residues:
512

# Metabolic_Enzyme_28_Molecular_Weight:
58166

# Metabolic_Enzyme_28_Theoretical_pI:
8.47

# Metabolic_Enzyme_28_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_28_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_28_Specific_Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics

# Metabolic_Enzyme_28_Pathway:
map00071  Fatty acid metabolism;
 map00361  gamma-Hexachlorocyclohexane degradation;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_28_Reaction:
RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O

# Metabolic_Enzyme_28_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_28_Signals:
1-28

# Metabolic_Enzyme_28_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_28_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_28_EC_Link:
EC 1.14.14.1

# Metabolic_Enzyme_28_GenBank_ID_Protein:
30341

# Metabolic_Enzyme_28_SwissProt_ID:
CP1A1_HUMAN (P04798)

# Metabolic_Enzyme_28_swissprot_Name:
Not Available

# Metabolic_Enzyme_28_Genecard_id:
CYP1A1

# Metabolic_Enzyme_28_Geneatlas_id:
CYP1A1

# Metabolic_Enzyme_28_hgnc_id:
HGNC:2595

# Metabolic_Enzyme_28_PDB_ID:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_28_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein

# Metabolic_Enzyme_28_Gene_Sequence:
>1539 bp
ATGCTTTTCCCAATCTCCATGTCGGCCACGGAGTTTCTTCTGGCCTCTGTCATCTTCTGT
CTGGTATTCTGGGTAATCAGGGCCTCAAGACCTCAGGTCCCCAAAGGCCTGAAGAATCCA
CCAGGGCCATGGGGCTGGCCTCTGATTGGGCACATGCTGACCCTGGGAAAGAACCCGCAC
CTGGCACTGTCAAGGATGAGCCAGCAGTATGGGGACGTGCTGCAGATCCGAATTGGCTCC
ACACCCGTGGTGGTGCTGAGCGGCCTGGACACCATCCGGCAGGCCCTGGTGCGGCAGGGC
GATGATTTCAAGGGCCGGCCCGACCTCTACACCTTCACCCTCATCAGTAATGGTCAGAGC
ATGTCCTTCAGCCCAGACTCTGGACCAGTGTGGGCTGCCCGCCGGCGCCTGGCCCAGAAT
GGCCTGAAAAGTTTCTCCATTGCCTCTGACCCAGCCTCCTCAACCTCCTGCTACCTGGAA
GAGCATGTGAGCAAGGAGGCTGAGGTCCTGATAAGCACGTTGCAGGAGCTGATGGCAGGG
CCTGGGCACTTTAACCCCTACAGGTATGTGGTGGTATCAGTGACCAATGTCATCTGTGCC
ATTTGCTTTGGCCGGCGCTATGACCACAACCACCAAGAACTGCTTAGCCTAGTCAACCTG
AATAATAATTTCGGGGAGGTGGTTGGCTCTGGAAACCCAGCTGACTTCATCCCTATTCTT
CGCTACCTACCCAACCCTTCCCTGAATGCCTTCAAGGACCTGAATGAGAAGTTCTACAGC
TTCATGCAGAAGATGGTCAAGGAGCACTACAAAACCTTTGAGAAGGGCCACATCCGGGAC
ATCACAGACAGCCTGATTGAGCACTGTCAGGAGAAGCAGCTGGATGAGAACGCCAATGTC
CAGCTGTCAGATGAGAAGATCATTAACATCGTCTTGGACCTCTTTGGAGCTGGGTTTGAC
ACAGTCACAACTGCTATCTCCTGGAGCCTCATGTATTTGGTGATGAACCCCAGGGTACAG
AGAAAGATCCAAGAGGAGCTAGACACAGTGATTGGCAGGTCACGGCGGCCCCGGCTCTCT
GACAGATCCCATCTGCCCTATATGGAGGCCTTCATCCTGGAGACCTTCCGACACTCTTCC
TTAGTCCCCTTCACCATCCCCCACAGCACAACAAGAGACACAAGTTTGAAAGGCTTTTAC
ATCCCCAAGGGGCGTTGTGTCTTTGTAAACCAGTGGCAGATCAACCATGACCAGAAGCTA
TGGGTCAACCCATCTGAGTTCCTACCTGAACGGTTTCTCACCCCTGATGGTGCTATCGAC
AAGGTGTTAAGTGAGAAGGTGATTATCTTTGGCATGGGCAAGCGGAAGTGTATCGGTGAG
ACCGTTGCCCGCTGGGAGGTCTTTCTCTTCCTGGCTATCCTGCTGCAACGGGTGGAATTC
AGCGTGCCACTGGGCGTGAAGGTGGACATGACCCCCATCTATGGGCTAACCATGAAGCAT
GCCTGCTGTGAGCACTTCCAAATGCAGCTGCGCTCTTAG

# Metabolic_Enzyme_28_GenBank_ID_Gene:
X02612

# Metabolic_Enzyme_28_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_28_Locus:
15q22-q24

# Metabolic_Enzyme_28_SNPs:
rs28399427; rs4646422; rs1048943; rs1799814; rs17861094; rs2278970; rs36121583; rs35035798; rs34260157; rs2229150; rs28399426; rs35267501; rs8031941; rs4646421; rs4986882; rs28399431; rs17861084; rs4986884; rs4986880; rs28399432; rs2606345; rs17861085; rs4986883; rs4986881; rs34748766; rs35766947; rs34331219; rs4646420; rs34268526; rs2606344; rs35892217; rs34726614; rs35543944; rs35120102; rs2606346; rs35374834; rs35089928; rs4986885; rs1800031; rs34513002; rs34445263; rs35992445; rs4986879; rs4646903; rs7495708; rs3826041; rs2470893; rs17861104; rs4646417; rs17861099; rs4646418; rs35686934; rs35141552; rs35701229; rs34077361; rs36074335; rs3826042; rs36090160; rs36018288; rs36099343; rs35339247; rs3809585; rs34458627; rs41279188; rs2856833; rs4987133; rs35196245; rs28399430; rs28399429; rs35228499; rs28399425; rs35427048; rs2856844; rs17861086; rs17861097; rs28427336; rs28399428; rs41279190; rs11334544; rs34255805; rs2472296; rs17861081; rs2856831; rs4646424; rs35037664; rs28588839; rs2445619; rs35463883; rs17861080; rs2856832; rs2472307; rs34796618; rs17861082; rs2515900; rs28661955; rs11631784; rs12441817; rs1456432; rs2470891; rs2470892; rs2472309; rs4886605; rs7496395; rs936225

# Metabolic_Enzyme_28_General_References:
2989797; 3838385; 3019683; 11207026; 9500998; 3000715; 1722803; 8895751; 10739168; 11295847

# Metabolic_Enzyme_28_References:
12865317; 12902195; 16103451

# Metabolic_Enzyme_29_ID:
5740

# Metabolic_Enzyme_29_Name:
Steryl-sulfatase precursor

# Metabolic_Enzyme_29_Synonyms:
Steroid sulfatase; Steryl- sulfate sulfohydrolase; Arylsulfatase C; ASC

# Metabolic_Enzyme_29_Gene_Name:
STS

# Metabolic_Enzyme_29_Protein_Sequence:
>Sterylsulfatase precursor
MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLAS
GGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAK
LLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTT
GFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPL
NCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFA
GKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGS
NGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRI
IDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNG
CFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQT
LPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR

# Metabolic_Enzyme_29_Number_of_Residues:
583

# Metabolic_Enzyme_29_Molecular_Weight:
65493

# Metabolic_Enzyme_29_Theoretical_pI:
7.71

# Metabolic_Enzyme_29_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  sulfuric ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_29_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_29_Specific_Function:
Conversion of sulfated steroid precursors to estrogens during pregnancy

# Metabolic_Enzyme_29_Pathway:
map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_29_Reaction:
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate

# Metabolic_Enzyme_29_Pfam_Domain_Function:
PF00884:Sulfatase

# Metabolic_Enzyme_29_Signals:
1-21

# Metabolic_Enzyme_29_Transmembrane_Regions:
185-208
213-234

# Metabolic_Enzyme_29_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_29_EC_Link:
EC 3.1.6.2

# Metabolic_Enzyme_29_GenBank_ID_Protein:
338565

# Metabolic_Enzyme_29_SwissProt_ID:
STS_HUMAN (P08842)

# Metabolic_Enzyme_29_swissprot_Name:
Not Available

# Metabolic_Enzyme_29_Genecard_id:
STS

# Metabolic_Enzyme_29_Geneatlas_id:
STS

# Metabolic_Enzyme_29_hgnc_id:
HGNC:11425

# Metabolic_Enzyme_29_PDB_ID:
1P49

# Metabolic_Enzyme_29_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_29_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein

# Metabolic_Enzyme_29_Gene_Sequence:
>1752 bp
ATGCCTTTAAGGAAGATGAAGATCCCTTTCCTCCTACTGTTCTTTCTGTGGGAAGCCGAG
AGCCACGCAGCATCAAGGCCGAACATCATCCTGGTGATGGCTGACGACCTCGGCATTGGA
GATCCTGGGTGCTATGGGAACAAAACTATCAGGACTCCCAATATCGACCGGTTGGCCAGT
GGGGGAGTGAAACTCACTCAGCACCTGGCAGCATCACCGCTGTGCACACCAAGCAGGGCA
GCCTTCATGACTGGCCGGTACCCTGTCCGATCAGGAATGGCATCTTGGTCCCGCACTGGA
GTTTTCCTCTTCACAGCCTCTTCGGGAGGACTTCCCACCGATGAGATTACCTTTGCTAAG
CTTCTGAAGGATCAAGGTTATTCAACAGCACTGATAGGGAAATGGCACCTTGGGATGAGC
TGTCACAGCAAGACTGACTTCTGTCACCACCCTTTACATCACGGCTTCAATTATTTCTAT
GGGATCTCTTTGACCAATCTGAGAGACTGCAAGCCCGGAGAGGGCAGTGTCTTCACCACG
GGCTTCAAGAGGCTGGTCTTCCTCCCCCTGCAGATCGTCGGGGTCACCCTCCTTACCCTT
GCTGCACTCAATTGTCTGGGGCTACTCCACGTGCCTCTAGGCGTTTTTTTCAGCCTTCTC
TTCCTAGCAGCCCTAATCCTGACCCTTTTCTTGGGCTTCCTTCATTACTTCCGGCCCCTG
AACTGCTTCATGATGAGGAACTACGAGATCATTCAGCAGCCCATGTCCTATGACAATCTC
ACCCAGAGGCTAACGGTGGAGGCGGCCCAGTTCATACAGCGGAACACTGAGACTCCGTTC
CTGCTTGTCTTGTCCTACCTCCACGTGCACACAGCCCTGTTCTCCAGCAAAGACTTTGCT
GGCAAAAGTCAACACGGAGTCTACGGGGATGCTGTTGAGGAAATGGACTGGAGTGTGGGG
CAGATCTTGAACCTTCTGGATGAGCTGAGATTGGCTAATGATACCCTCATCTACTTCACA
TCGGACCAGGGAGCACATGTAGAGGAGGTGTCTTCCAAAGGAGAAATTCATGGCGGAAGT
AATGGGATCTATAAAGGAGGAAAAGCAAACAACTGGGAAGGAGGTATCCGGGTTCCAGGC
ATCCTTCGTTGGCCCAGGGTGATACAGGCTGGCCAGAAGATTGATGAGCCCACTAGCAAC
ATGGACATATTTCCTACAGTAGCCAAGCTGGCTGGAGCTCCCTTGCCTGAGGACAGGATC
ATTGATGGACGTGATCTGATGCCCCTGCTTGAAGGAAAAAGCCAACGCTCCGATCATGAG
TTTCTCTTCCATTACTGCAACGCCTACTTAAATGCTGTGCGCTGGCACCCTCAGAACAGC
ACATCCATCTGGAAGGCCTTTTTCTTCACCCCCAACTTCAACCCCGTGGGTTCCAACGGA
TGCTTTGCCACACACGTGTGCTTCTGTTTCGGGAGTTATGTCACCCATCACGACCCACCT
TTACTCTTTGATATTTCCAAAGATCCCAGAGAGAGAAACCCACTAACTCCAGCATCCGAG
CCCCGGTTTTATGAAATCCTCAAAGTCATGCAGGAAGCTGCGGACAGACACACCCAGACC
CTGCCAGAGGTGCCCGATCAGTTTTCATGGAACAACTTTCTTTGGAAGCCCTGGCTTCAG
CTGTGCTGTCCTTCCACCGGCCTGTCTTGCCAGTGTGATAGAGAAAAACAGGATAAGAGA
CTGAGCCGCTAG

# Metabolic_Enzyme_29_GenBank_ID_Gene:
J04964

# Metabolic_Enzyme_29_Chromosome_Location:
Not Available

# Metabolic_Enzyme_29_Locus:
Not Available

# Metabolic_Enzyme_29_SNPs:
Not Available

# Metabolic_Enzyme_29_General_References:
2668275; 3032454; 3203382; 2765556; 12657638; 1539590; 9252398; 10679952; 10844566

# Metabolic_Enzyme_29_References:
12659755; 12782580; 15145451; 15341968

# Metabolic_Enzyme_30_ID:
7434

# Metabolic_Enzyme_30_Name:
Caspase-3 precursor

# Metabolic_Enzyme_30_Synonyms:
CASP-3; Apopain; Cysteine protease CPP32; Yama protein; CPP-32; SREBP cleavage activity 1; SCA-1[Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]

# Metabolic_Enzyme_30_Gene_Name:
CASP3

# Metabolic_Enzyme_30_Protein_Sequence:
>Caspase3 precursor
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

# Metabolic_Enzyme_30_Number_of_Residues:
277

# Metabolic_Enzyme_30_Molecular_Weight:
31608

# Metabolic_Enzyme_30_Theoretical_pI:
6.51

# Metabolic_Enzyme_30_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  cysteine-type endopeptidase activity
Function:  caspase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_30_General_Function:
Not Available

# Metabolic_Enzyme_30_Specific_Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin

# Metabolic_Enzyme_30_Pathway:
Not Available

# Metabolic_Enzyme_30_Reaction:
Not Available

# Metabolic_Enzyme_30_Pfam_Domain_Function:
PF00656:Peptidase_C14

# Metabolic_Enzyme_30_Signals:
None

# Metabolic_Enzyme_30_Transmembrane_Regions:
None

# Metabolic_Enzyme_30_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_30_EC_Link:
EC 3.4.22.56

# Metabolic_Enzyme_30_GenBank_ID_Protein:
561666

# Metabolic_Enzyme_30_SwissProt_ID:
CASP3_HUMAN (P42574)

# Metabolic_Enzyme_30_swissprot_Name:
Not Available

# Metabolic_Enzyme_30_Genecard_id:
CASP3

# Metabolic_Enzyme_30_Geneatlas_id:
CASP3

# Metabolic_Enzyme_30_hgnc_id:
HGNC:1504

# Metabolic_Enzyme_30_PDB_ID:
1CP3

# Metabolic_Enzyme_30_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_30_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_30_Gene_Sequence:
>834 bp
ATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATC
ATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGAT
TATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGA
ATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAAC
TTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATG
CGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGC
CATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACA
AACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATT
CAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGAT
GACATGGCGTGTCATAAAATACCAGTGGATGCCGACTTCTTGTATGCATACTCCACAGCA
CCTGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGT
GCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAAC
CGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAA
CAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAA

# Metabolic_Enzyme_30_GenBank_ID_Gene:
U13737

# Metabolic_Enzyme_30_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_30_Locus:
4q34

# Metabolic_Enzyme_30_SNPs:
rs35578277; rs1049210; rs35566035; rs1049253; rs2720378; rs3087455; rs6948; rs4647640; rs4647610; rs4647617; rs4647642; rs4647634; rs4647611; rs4647620; rs1049216; rs4647641; rs4647618; rs4647609; rs4647694; rs8549; rs4647698; rs4647614; rs4647621; rs4647622; rs4647616; rs4647633; rs4647643; rs4647630; rs34184817; rs4647647; rs35422505; rs4647624; rs4647626; rs4647696; rs4647606; rs4647631; rs4647646; rs4647607; rs4647625; rs34022730; rs35439719; rs2720377; rs4647632; rs4647628; rs2310103; rs34309992; rs4647629; rs4647644; rs4647636; rs2019978; rs2705891; rs1830254; rs2720376; rs2696056; rs4241793; rs4647667; rs4647688; rs4647663; rs1405942; rs4647652; rs1405938; rs4647662; rs2705901; rs1405944; rs4647671; rs4647665; rs2696057; rs4647693; rs4647672; rs2705897; rs4647669; rs4647673; rs4647692; rs4647674; rs4647666; rs4647686; rs4647683; rs4647690; rs4647657; rs4987118; rs4647679; rs4647670; rs4987119; rs4647658; rs4647684; rs4647675; rs4647650; rs34319440; rs4647685; rs2696048; rs4647651; rs4647676; rs4647687; rs4647655; rs13128316; rs13435139; rs4647704; rs4647700; rs12646257; rs4647701; rs4647623; rs4647635; rs10028033; rs12641602; rs13101834; rs11380373; rs4647695; rs34119644; rs2705892; rs34858791; rs35063555; rs4647699; rs4647639; rs34095700; rs4647619; rs13102911; rs4647645; rs4647612; rs13101835; rs4647637; rs4647638; rs2705893; rs4647649; rs2696060; rs10028034; rs4647697; rs4647613; rs35978407; rs4647608; rs4647615; rs28418774; rs4647648; rs1802667; rs34568867; rs7442206; rs4647682; rs4647656; rs4647681; rs4647668; rs4647677; rs4647678; rs4647691; rs35261594; rs4647689; rs4647653; rs35966919; rs34740772; rs4647659; rs41314884; rs9997231; rs3215361; rs4647661; rs4647654; rs10014306; rs10660141; rs4647664; rs4647660; rs4647680; rs10034836; rs35094553; rs9715122; rs4647705; rs34083547; rs9715863; rs4647702; rs4647703; rs11930666; rs12108497; rs12507711; rs13108061; rs13435890; rs1405937; rs2696058; rs2696059; rs2705881; rs2705882; rs2705900; rs2720388; rs2720389; rs34605630; rs4647600; rs4647602; rs4647603; rs4647605; rs4861629; rs4862396; rs4862399; rs7673753; rs7674164; rs7687648; rs9685847

# Metabolic_Enzyme_30_General_References:
7983002; 7774019; 7596430; 8673606; 9045680; 10821855; 8755496; 8696339

# Metabolic_Enzyme_30_References:
14698758; 15985705

# Metabolic_Enzyme_31_ID:
6843

# Metabolic_Enzyme_31_Name:
Cytochrome P450 1B1

# Metabolic_Enzyme_31_Synonyms:
CYPIB1

# Metabolic_Enzyme_31_Gene_Name:
CYP1B1

# Metabolic_Enzyme_31_Protein_Sequence:
>Cytochrome P450 1B1
MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI
GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF
ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL
LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL
VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSA
EKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAEL
DQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVV
FVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL
FLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKE
TCQ

# Metabolic_Enzyme_31_Number_of_Residues:
543

# Metabolic_Enzyme_31_Molecular_Weight:
60847

# Metabolic_Enzyme_31_Theoretical_pI:
9.23

# Metabolic_Enzyme_31_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_31_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_31_Specific_Function:
Participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development

# Metabolic_Enzyme_31_Pathway:
map00071  Fatty acid metabolism;
 map00361  gamma-Hexachlorocyclohexane degradation;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_31_Reaction:
RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O

# Metabolic_Enzyme_31_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_31_Signals:
1-36

# Metabolic_Enzyme_31_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_31_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_31_EC_Link:
EC 1.14.14.1

# Metabolic_Enzyme_31_GenBank_ID_Protein:
501031

# Metabolic_Enzyme_31_SwissProt_ID:
CP1B1_HUMAN (Q16678)

# Metabolic_Enzyme_31_swissprot_Name:
Not Available

# Metabolic_Enzyme_31_Genecard_id:
CYP1B1

# Metabolic_Enzyme_31_Geneatlas_id:
CYP1B1

# Metabolic_Enzyme_31_hgnc_id:
HGNC:2597

# Metabolic_Enzyme_31_PDB_ID:
Not Available

# Metabolic_Enzyme_31_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_31_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_31_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein

# Metabolic_Enzyme_31_Gene_Sequence:
>1632 bp
ATGGGCACCAGCCTCAGCCCGAACGACCCTTGGCCGCTAAACCCGCTGTCCATCCAGCAG
ACCACGCTCCTGCTACTCCTGTCGGTGCTGGCCACTGTGCATGTGGGCCAGCGGCTGCTG
AGGCAACGGAGGCGGCAGCTCCGGTCCGCGCCCCCGGGCCCGTTTGCGTGGCCACTGATC
GGAAACGCGGCGGCGGTGGGCCAGGCGGCTCACCTCTCGTTCGCTCGCCTGGCGCGGCGC
TACGGCGACGTTTTCCAGATCCGCCTGGGCAGCTGCCCCATAGTGGTGCTGAATGGCGAG
CGCGCCATCCACCAGGCCCTGGTGCAGCAGGGCTCGGCCTTCGCCGACCGGCCGGCCTTC
GCCTCCTTCCGTGTGGTGTCCGGCGGCCGCAGCATGGCTTTCGGCCACTACTCGGAGCAC
TGGAAGGTGCAGCGGCGCGCAGCCCACAGCATGATGCGCAACTTCTTCACGCGCCAGCCG
CGCAGCCGCCAAGTCCTCGAGGGCCACGTGCTGAGCGAGGCGCGCGAGCTGGTGGCGCTG
CTGGTGCGCGGCAGCGCGGACGGCGCCTTCCTCGACCCGAGGCCGCTGACCGTCGTGGCC
GTGGCCAACGTCATGAGTGCCGTGTGTTTCGGCTGCCGCTACAGCCACGACGACCCCGAG
TTCCGTGAGCTGCTCAGCCACAACGAAGAGTTCGGGCGCACGGTGGGCGCGGGCAGCCTG
GTGGACGTGATGCCCTGGCTGCAGTACTTCCCCAACCCGGTGCGCACCGTTTTCCGCGAA
TTCGAGCAGCTCAACCGCAACTTCAGCAACTTCATCCTGGACAAGTTCTTGAGGCACTGC
GAAAGCCTTCGGCCCGGGGCCGCCCCCCGCGACATGATGGACGCCTTTATCCTCTCTGCG
GAAAAGAAGGCGGCCGGGGACTCGCACGGTGGTGGCGCGCGGCTGGATTTGGAGAACGTA
CCGGCCACTATCACTGACATCTTCGGCGCCAGCCAGGACACCCTGTCCACCGCGCTGCAG
TGGCTGCTCCTCCTCTTCACCAGGTATCCTGATGTGCAGACTCGAGTGCAGGCAGAATTG
GATCAGGTCGTGGGGAGGGACCGTCTGCCTTGTATGGGTGACCAGCCCAACCTGCCCTAT
GTCCTGGCCTTCCTTTATGAAGCCATGCGCTTCTCCAGCTTTGTGCCTGTCACTATTCCT
CATGCCACCACTGCCAACACCTCTGTCTTGGGCTACCACATTCCCAAGGACACTGTGGTT
TTTGTCAACCAGTGGTCTGTGAATCATGACCCAGTGAAGTGGCCTAACCCGGAGAACTTT
GATCCAGCTCGATTCTTGGACAAGGATGGCCTCATCAACAAGGACCTGACCAGCAGAGTG
ATGATTTTTTCAGTGGGCAAAAGGCGGTGCATTGGCGAAGAACTTTCTAAGATGCAGCTT
TTTCTCTTCATCTCCATCCTGGCTCACCAGTGCGATTTCAGGGCCAACCCAAATGAGCCT
GCGAAAATGAATTTCAGTTATGGTCTAACCATTAAACCCAAGTCATTTAAAGTCAATGTC
ACTCTCAGAGAGTCCATGGAGCTCCTTGATAGTGCTGTCCAAAATTTACAAGCCAAGGAA
ACTTGCCAATAA

# Metabolic_Enzyme_31_GenBank_ID_Gene:
U03688

# Metabolic_Enzyme_31_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_31_Locus:
2p21

# Metabolic_Enzyme_31_SNPs:
rs1056837; rs1056836; rs1800440; rs1056827; rs4986888; rs10012; rs9341248; rs9341250; rs9282671; rs9282670; rs9341247; rs4987137; rs9341249; rs34731639; rs4986889; rs4987135; rs162549; rs2551188; rs2855658; rs162562; rs10916; rs2617266; rs9341262; rs9341266; rs1799885; rs9341261; rs9341265; rs9341268; rs9341244; rs4987134; rs9309020; rs9341258; rs34521017; rs34819684; rs34602510; rs35275599; rs34329725; rs35007750; rs34544682; rs34383932; rs34474461; rs1056843; rs34169771; rs35978993; rs11387544; rs9341245; rs9341263; rs35320531; rs2672; rs162560; rs9341252; rs162561; rs6759786; rs9341253; rs7599999; rs11453846; rs35973441; rs9341254; rs34443711; rs9341242; rs162558; rs2855655; rs2567206; rs9341240; rs9341243; rs9341239; rs34441600; rs34159921; rs2567207; rs28936701; rs4986887; rs4398252; rs28936700; rs4987136; rs9341246; rs1056876; rs3834137; rs4646431; rs4646432; rs11379588; rs34547695; rs9341259; rs4646433; rs162559; rs4630747; rs9341260; rs3755026; rs9341267; rs9341264; rs9341257; rs9341256; rs9341251; rs34468862; rs9341255; rs35869448; rs12993690; rs35995717; rs2855657; rs35217661; rs2551190; rs34908810; rs2551189; rs9341238; rs34579671; rs9341241; rs9341237; rs2855656; rs3057354; rs10175338; rs10175368; rs1157184; rs1157185; rs1367696; rs151253; rs162555; rs162556; rs162557; rs163077; rs163078; rs163084; rs163086; rs2256327; rs2567204; rs3770140; rs4646429; rs4646430; rs6760346; rs7571060; rs7606923; rs9341270

# Metabolic_Enzyme_31_General_References:
8175734; 8910454; 9463332; 9497261; 9823305; 11774072

# Metabolic_Enzyme_31_References:
12902195; 16103451

# Macromolecular_Interacting_Partner_1_ID:
7546

# Macromolecular_Interacting_Partner_1_Name:
Prolactin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
PRL

# Macromolecular_Interacting_Partner_1_Gene_Name:
PRL

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Prolactin precursor
MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN
EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG
LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
227

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
25876

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.99

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Prolactin acts primarily on the mammary gland by promoting lactation

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_1_Signals:
1-28

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
34211

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
PRL_HUMAN (P01236)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
PRL

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
PRL

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9445

# Macromolecular_Interacting_Partner_1_PDB_ID:
1RW5

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>684 bp
ATGAACATCAAAGGATCGCCATGGAAAGGGTCCCTCCTGCTGCTGCTGGTGTCAAACCTG
CTGCTGTGCCAGAGCGTGGCCCCCTTGCCCATCTGTCCCGGCGGGGCTGCCCGATGCCAG
GTGACCCTTCGAGACCTGTTTGACCGCGCCGTCGTCCTGTCCCACTACATCCATAACCTC
TCCTCAGAAATGTTCAGCGAATTCGATAAACGGTATACCCATGGCCGGGGGTTCATTACC
AAGGCCATCAACAGCTGCCACACTTCTTCCCTTGCCACCCCCGAAGACAAGGAGCAAGCC
CAACAGATGAATCAAAAAGACTTTCTGAGCCTGATAGTCAGCATATTGCGATCCTGGAAT
GAGCCTCTGTATCATCTGGTCACGGAAGTACGTGGTATGCAAGAAGCCCCGGAGGCTATC
CTATCCAAAGCTGTAGAGATTGAGGAGCAAACCAAACGGCTTCTAGAGGGCATGGAGCTG
ATAGTCAGCCAGGTTCATCCTGAAACCAAAGAAAATGAGATCTACCCTGTCTGGTCGGGA
CTTCCATCCCTGCAGATGGCTGATGAAGAGTCTCGCCTTTCTGCTTATTATAACCTGCTC
CACTGCCTACGCAGGGATTCACATAAAATCGACAATTATCTCAAGCTCCTGAAGTGCCGA
ATCATCCACAACAACAACTGCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00566

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_1_Locus:
6p22.2-p21.3

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
6260780; 6325171; 2050267; 6146607; 9266104; 925136; 1126929

# Macromolecular_Interacting_Partner_1_References:
15528265; 16284390

# Macromolecular_Interacting_Partner_2_ID:
7549

# Macromolecular_Interacting_Partner_2_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
INS

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_2_Signals:
1-24

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
INS

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_2_Locus:
11p15.5

# Macromolecular_Interacting_Partner_2_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_2_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_2_References:
12166825; 14667889; 16492698

# Macromolecular_Interacting_Partner_3_ID:
7559

# Macromolecular_Interacting_Partner_3_Name:
Estrogen receptor

# Macromolecular_Interacting_Partner_3_Synonyms:
ER; Estradiol receptor; ER-alpha

# Macromolecular_Interacting_Partner_3_Gene_Name:
ESR1

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Estrogen receptor
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
595

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
66217

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
8.14

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  steroid binding
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF02159:Oest_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
31620888

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
ESR1_HUMAN (P03372)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
ESR1

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
ESR1

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:3467

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>63 bp
ATGCGCTGCGTCGCCTCTAACCTCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTC
TGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
X03635

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_3_Locus:
6q25.1

# Macromolecular_Interacting_Partner_3_SNPs:
Not Available

# Macromolecular_Interacting_Partner_3_General_References:
3753802; 3754034; 8600466; 14574404; 10619354; 7916651; 7476978; 7539106; 1577818; 7838153; 9627117; 10428798; 10567404; 10359819; 11113208; 11971969; 12415108; 2247153; 8221895; 9338790; 9600906; 9875847; 9619507; 2792078; 8961262; 9195227

# Macromolecular_Interacting_Partner_3_References:
11294976; 12796390; 12866733; 15101754

# Macromolecular_Interacting_Partner_4_ID:
6946

# Macromolecular_Interacting_Partner_4_Name:
Sex hormone-binding globulin precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
SHBG; Sex steroid-binding protein; SBP; Testis-specific androgen-binding protein; ABP; Testosterone-estrogen-binding globulin; Testosterone-estradiol- binding globulin; TeBG

# Macromolecular_Interacting_Partner_4_Gene_Name:
SHBG

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Sex hormonebinding globulin precursor
MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMT
FDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGA
GPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPAS
NLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDI
PQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPL
VLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTS
FCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
402

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
43780

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.70

# Macromolecular_Interacting_Partner_4_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00054:Laminin_G_1

# Macromolecular_Interacting_Partner_4_Signals:
1-29

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
296673

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
SHBG_HUMAN (P04278)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SHBG

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SHBG

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:10839

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis (By similarity)

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1209 bp
ATGGAGAGCAGAGGCCCACTGGCTACCTCGCGCCTGCTGCTGTTGCTGCTGTTGCTACTA
CTGCGTCACACCCGCCAGGGATGGGCCCTGAGACCTGTTCTCCCCACCCAGAGTGCCCAC
GACCCTCCGGCTGTCCACCTCAGCAATGGCCCAGGACAAGAGCCTATCGCTGTCATGACC
TTTGACCTCACCAAGATCACAAAAACCTCCTCCTCCTTTGAGGTTCGAACCTGGGACCCA
GAGGGAGTGATTTTTTATGGGGATACCAACCCTAAGGATGACTGGTTTATGCTGGGACTT
CGAGACGGCAGGCCTGAGATCCAACTGCACAATCACTGGGCCCAGCTTACGGTGGGTGCT
GGACCACGGCTGGATGATGGGAGATGGCACCAGGTGGAAGTCAAGATGGAGGGGGACTCT
GTGCTGCTGGAGGTGGATGGGGAGGAGGTGCTGCGCCTGAGACAGGTCTCTGGGCCCCTG
ACCAGCAAACGCCATCCCATCATGAGGATTGCGCTTGGGGGGCTGCTCTTCCCCGCTTCC
AACCTTCGGTTGCCGCTGGTTCCTGCCCTGGATGGCTGCCTGCGCCGGGATTCCTGGCTG
GACAAACAGGCCGAGATCTCAGCATCTGCCCCCACTAGCCTCAGAAGCTGTGATGTAGAA
TCAAATCCCGGGATATTTCTCCCTCCAGGGACTCAGGCAGAATTCAATCTCCGAGACATT
CCCCAGCCTCATGCAGAGCCCTGGGCCTTCTCTTTGGACCTGGGACTCAAGCAGGCAGCA
GGCTCAGGCCACCTCCTTGCTCTTGGGACACCAGAGAACCCATCTTGGCTCAGTCTCCAC
CTCCAAGATCAAAAGGTGGTGTTGTCTTCTGGGTCGGGGCCAGGGCTGGATCTGCCCCTG
GTCTTGGGACTCCCTCTTCAGCTGAAGCTGAGTATGTCCAGGGTGGTCTTGAGCCAAGGG
TCGAAGATGAAGGCCCTTGCCCTGCCTCCCTTAGGCCTGGCTCCCCTCCTTAACCTCTGG
GCCAAGCCTCAAGGGCGTCTCTTCCTGGGGGCTTTACCAGGAGAAGACTCTTCCACCTCT
TTTTGCCTGAATGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAAC
AGAAGCCATGAGATCTGGACTCACAGCTGCCCCCAGAGCCCAGGCAATGGCACTGACGCT
TCCCATTAA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
X16349

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_4_Locus:
17p13-p12

# Macromolecular_Interacting_Partner_4_SNPs:
rs6260; rs6258; rs9282845; rs6259; rs6261; rs4987212; rs9282846; rs6257; rs9913778; rs858517; rs1799941; rs858516; rs35167070; rs34865989; rs34420533; rs35338190; rs3760213; rs8065089; rs5030659; rs13894; rs1641536; rs1641537; rs1641544; rs1642800; rs2543553; rs2955617; rs34780532; rs727428; rs858520; rs858521; rs9898876

# Macromolecular_Interacting_Partner_4_General_References:
2587256; 2608061; 3569533; 2956126; 2956125; 3702459; 3542030; 1400872; 10675319; 12065592; 7714097; 10391209

# Macromolecular_Interacting_Partner_4_References:
10067812; 10430063; 10798211; 10868692

# Macromolecular_Interacting_Partner_5_ID:
7623

# Macromolecular_Interacting_Partner_5_Name:
Insulin-like growth factor-binding protein 3 precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
IGFBP-3; IBP- 3; IGF-binding protein 3

# Macromolecular_Interacting_Partner_5_Gene_Name:
IGFBP3

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Insulinlike growth factorbinding protein 3 precursor
MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAE
LVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAV
SRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHA
KDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNC
DKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
291

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
31674

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
8.78

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  growth factor binding
Function:  insulin-like growth factor binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of growth
Process:  regulation of cell growth
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00219:IGFBP;
PF00086:Thyroglobulin_1

# Macromolecular_Interacting_Partner_5_Signals:
1-27

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
183116

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
IBP3_HUMAN (P17936)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
IGFBP3

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
IGFBP3

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:5472

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>876 bp
ATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGCTGGTGCTGCTCCGC
GGGCCGCCGGTGGCGCGGGCTGGCGCGAGCTCGGGGGGCTTGGGTCCCGTGGTGCGCTGC
GAGCCGTGCGACGCGCGTGCACTGGCCCAGTGCGCGCCTCCGCCCGCCGTGTGCGCGGAG
CTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGAGCGAGGGCCAGCCG
TGCGGCATCTACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAG
GCGCGACCGCTGCAGGCGCTGCTGGACGGCCGCGGGCTCTGCGTCAACGCTAGTGCCGTC
AGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGAAATGCTAGTGAGTCG
GAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTG
TCTGATCCCAAGTTCCACCCCCTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCT
AAAGACAGCCAGCGCTACAAAGTTGACTACGAGTCTCAGAGCACAGATACCCAGAACTTC
TCCTCCGAGTCCAAGCGGGAGACAGAATATGGTCCCTGCCGTAGAGAAATGGAAGACACA
CTGAATCACCTGAAGTTCCTCAATGTGCTGAGTCCCAGGGGTGTACACATTCCCAACTGT
GACAAGAAGGGATTTTATAAGAAAAAGCAGTGTCGCCCTTCCAAAGGCAGGAAGCGGGGC
TTCTGCTGGTGTGTGGATAAGTATGGGCAGCCTCTCCCAGGCTACACCACCAAGGGGAAG
GAGGACGTGCACTGCTACAGCATGCAGAGCAAGTAG

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
M31159

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_5_Locus:
7p13-p12

# Macromolecular_Interacting_Partner_5_SNPs:
rs9282734; rs2854746; rs6950868; rs6670; rs2453840; rs2453839; rs34505796; rs35496550; rs35751739; rs34460927; rs34835646; rs3110697; rs6413441; rs6950802; rs2854747; rs6953668; rs33979592; rs2471551; rs12540724; rs3793345; rs2453837; rs35890775; rs34508316; rs34678704; rs10255707; rs34091405; rs17847673; rs1800906; rs35052563; rs34876509; rs34463602; rs2854750; rs35440925; rs34672517; rs9282735; rs10282088; rs11765572; rs10252403; rs2132570; rs13223993; rs10238613; rs2132572; rs2132571; rs13241830; rs35709394; rs35258778; rs34087654; rs34122177; rs34480712; rs34077804; rs3763500; rs2854744; rs35712717; rs17847676; rs34257987; rs34239916; rs34663167; rs35925180; rs2471549; rs34735423; rs11537920; rs11537915; rs9911; rs11537916; rs11537919; rs1050566; rs34735308; rs11537917; rs35704214; rs34930524; rs35689043; rs2515697; rs2854749; rs34515169; rs34833729; rs17847674; rs2645039; rs34988007; rs3110696; rs35683959; rs5883949; rs34331516; rs34014638; rs2645038; rs34898986; rs35350851; rs2645037; rs13230567; rs35872082; rs34720178; rs2854751; rs34424795; rs2854748; rs35855621; rs35610649; rs11292609; rs34881353; rs34006338; rs4302754; rs34533777; rs34351332; rs35017224; rs2854745; rs34097876; rs34058026; rs34939676; rs35533791; rs35919935; rs2645036; rs35300175; rs11773396; rs10230447; rs12671457; rs12671484; rs12702181; rs2088300; rs2088301; rs2270628; rs2453836; rs2515696; rs885555; rs903889; rs924140

# Macromolecular_Interacting_Partner_5_General_References:
2464130; 1695633; 7508771; 12853948; 1697583; 14561895

# Macromolecular_Interacting_Partner_5_References:
12505887; 14578144; 14763914; 16773200

# Macromolecular_Interacting_Partner_6_ID:
8081

# Macromolecular_Interacting_Partner_6_Name:
Leptin precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
Obesity factor; Obese protein

# Macromolecular_Interacting_Partner_6_Gene_Name:
LEP

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Leptin precursor
MHWGTLCGFLWLWPYLFYVQAVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGL
DFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLP
WASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
167

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
18641

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
6.34

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF02024:Leptin

# Macromolecular_Interacting_Partner_6_Signals:
1-21

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
623332

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
LEP_HUMAN (P41159)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
LEP

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
LEP

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:6553

# Macromolecular_Interacting_Partner_6_PDB_ID:
1AX8

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>504 bp
ATGCATTGGGGAACCCTGTGCGGATTCTTGTGGCTTTGGCCCTATCTTTTCTATGTCCAA
GCTGTGCCCATCCAAAAAGTCCAAGATGACACCAAAACCCTCATCAAGACAATTGTCACC
AGGATCAATGACATTTCACACACGCAGTCAGTCTCCTCCAAACAGAAAGTCACCGGTTTG
GACTTCATTCCTGGGCTCCACCCCATCCTGACCTTATCCAAGATGGACCAGACACTGGCA
GTCTACCAACAGATCCTCACCAGTATGCCTTCCAGAAACGTGATCCAAATATCCAACGAC
CTGGAGAACCTCCGGGATCTTCTTCACGTGCTGGCCTTCTCTAAGAGCTGCCACTTGCCC
TGGGCCAGTGGCCTGGAGACCTTGGACAGCCTGGGGGGTGTCCTGGAAGCTTCAGGCTAC
TCCACAGAGGTGGTGGCCCTGAGCAGGCTGCAGGGGTCTCTGCAGGACATGCTGTGGCAG
CTGGACCTCAGCCCTGGGTGCTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
U18915

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_6_Locus:
7q31.3

# Macromolecular_Interacting_Partner_6_SNPs:
rs17151919; rs13306517; rs28954113; rs11763517; rs4731426; rs10954173; rs11761556; rs4731427; rs2167270; rs7791621; rs10257175; rs12706832; rs11760956; rs7795794; rs28954116; rs11978419; rs10244329; rs17151922; rs2278814; rs28959471; rs10954174; rs4236625; rs7796202; rs28954117; rs28959470; rs28954095; rs28954101; rs28954086; rs28954099; rs28959468; rs3750034; rs28954093; rs2278815; rs2122627; rs28954379; rs28959474; rs28954082; rs41457646; rs28954114; rs28954096; rs28959476; rs28954084; rs28954102; rs28954100; rs2060713; rs28954090; rs28954098; rs28954105; rs28954118; rs11980266; rs28954091; rs12706831; rs28959475; rs28954094; rs28954083; rs28756049; rs11973652; rs3793162; rs17151913; rs17151914; rs6956510; rs2071045; rs3828942; rs7788818; rs10264361; rs28954109; rs28954110; rs28954108; rs28954111; rs791616; rs28954376; rs28954081; rs6976701; rs10262600; rs28954369; rs28954080; rs28954371; rs34104384; rs4728096; rs791620; rs28954372; rs28954373; rs28954375; rs35048003; rs28959478; rs10258300; rs12536535; rs28954378; rs13228377; rs1800564; rs1800583; rs28954097; rs11380467; rs35394014; rs28959469; rs10676401; rs28954106; rs1031340; rs28954115; rs1349398; rs34219283; rs28959472; rs28954088; rs10243710; rs6966536; rs28954104; rs10620014; rs34457895; rs13306516; rs33910507; rs28954107; rs41526944; rs41434248; rs28954087; rs34728887; rs28954103; rs28959473; rs41528456; rs17617757; rs28954089; rs28954092; rs34052732; rs10277407; rs28954112; rs41474844; rs13306518; rs35447711; rs34046133; rs36212573; rs28959477; rs36219262; rs791618; rs28954370; rs791619; rs34669250; rs10598051; rs28954377; rs36219261; rs28391558; rs791617; rs28954374; rs36219260; rs10249476; rs10264838; rs10276311; rs10487506; rs10954175; rs10954176; rs11770725; rs12535708; rs12535747; rs12537573; rs13245201; rs1349419; rs1376268; rs16871960; rs17151895; rs2060715; rs2167271; rs35854831; rs4731423; rs4731424; rs4731428; rs4731429; rs4731430; rs6949498; rs712722; rs7778154; rs7782257; rs7798338; rs7799039; rs7801674; rs7802530; rs791604; rs791606; rs791607; rs791608; rs791610; rs791611; rs791612; rs791613; rs791614; rs791615

# Macromolecular_Interacting_Partner_6_General_References:
7984236; 7789654; 8626726; 7499240; 8621021; 10428856; 9166907; 9144295; 9500540

# Macromolecular_Interacting_Partner_6_References:
12119575; 12505887

# Macromolecular_Interacting_Partner_7_ID:
8013

# Macromolecular_Interacting_Partner_7_Name:
Arylsulfatase H

# Macromolecular_Interacting_Partner_7_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Name:
ARSH

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Arylsulfatase 
HMTRNARPNIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSR
AAFLTGRYPIRSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKLLQHRGYRTGLIGKWHLG
LSCASRNDHCYHPLNHGFHYFYGVPFGLLSDCQASKTPELHRWLRIKLWISTVALALVPF
LLLIPKFARWFSVPWKVIFVFALLAFLFFTSWYSSYGFTRRWNCILMRNHEIIQQPMKEE
KVASLMLKEALAFIERYKREPFLLFFSFLHVHTPLISKKKFVGRSKYGRYGDNVEEMDWM
VGKILDALDQERLANHTLVYFTSDNGGHLEPLDGAVQLGGWNGIYKGGKGMGGWEGGIRV
PGIFRWPSVLEAGRVINEPTSLMDIYPTLSYIGGGILSQDRVIDGQNLMPLLEGRASHSD
HEFLFHYCGVYLHTVRWHQKDCATVWKAHYVTPKFYPEGTGACYGSGICSCSGDVTYHDP
PLLFDISRDPSEALPLNPDNEPLFDSVIKKMEAAIREHRRTLTPVPQQFSVFNTIWKPWL
QPCCGTFPFCGCDKEDDILPMAP

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
562

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
63526

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
8.24

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  sulfuric ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_7_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00884:Sulfatase

# Macromolecular_Interacting_Partner_7_Signals:
1-20

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
167-189; 196-218

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
58201090

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
Q5FYA8_HUMAN (Q5FYA8)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
ARSH

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
ARSH

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:32488

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1689 bp
ATGACAAGAAACGCCAGACCCAACATTGTCCTGCTGATGGCAGATGACCTTGGAGTGGGG
GATTTGTGCTGCTACGGTAATAACTCAGTGAGCACACCTAATATTGACCGCCTGGCAAGT
GAAGGAGTGAGGCTTACCCAGCATCTCGCAGCTGCTTCCATGTGCACCCCAAGTCGGGCT
GCCTTCCTGACCGGCCGGTACCCCATCAGATCAGGGATGGTGTCTGCCTACAACCTGAAC
CGTGCCTTCACGTGGCTTGGTGGGTCAGGTGGTCTTCCCACCAATGAAACGACTTTTGCC
AAGCTGCTGCAGCACCGTGGCTACCGCACGGGACTCATAGGCAAATGGCACCTGGGTTTG
AGCTGCGCCTCTCGGAATGATCACTGTTACCACCCGCTCAACCATGGTTTTCACTACTTT
TACGGGGTGCCTTTTGGACTTTTAAGCGACTGCCAGGCATCCAAGACACCAGAACTGCAC
CGCTGGCTCAGGATCAAACTGTGGATCTCCACGGTAGCCCTTGCCCTGGTTCCTTTTCTG
CTTCTCATTCCCAAGTTCGCCCGCTGGTTCTCAGTGCCATGGAAGGTCATCTTTGTCTTT
GCTCTCCTCGCCTTTCTGTTTTTCACTTCCTGGTACTCTAGTTATGGATTTACTCGACGT
TGGAATTGCATCCTTATGAGGAACCATGAAATTATCCAGCAGCCAATGAAAGAGGAGAAA
GTAGCTTCCCTCATGCTGAAGGAGGCACTTGCTTTCATTGAAAGGTACAAAAGGGAACCT
TTTCTCCTCTTTTTTTCCTTCCTGCACGTACATACTCCACTCATCTCCAAAAAGAAGTTT
GTTGGGCGCAGTAAATATGGCAGGTATGGGGACAATGTAGAAGAAATGGATTGGATGGTG
GGTAAAATCCTGGATGCCCTGGACCAGGAGCGCCTGGCCAACCACACCTTGGTGTACTTC
ACCTCTGACAACGGGGGCCACCTGGAGCCCCTGGACGGGGCTGTTCAGCTGGGTGGCTGG
AACGGGATCTACAAAGGTGGCAAAGGAATGGGAGGATGGGAAGGAGGTATCCGTGTGCCA
GGGATATTCCGGTGGCCGTCAGTCTTGGAGGCTGGGAGAGTGATCAATGAGCCCACCAGC
TTAATGGACATCTATCCGACGCTGTCTTATATAGGCGGAGGGATCTTGTCCCAGGACAGA
GTGATTGACGGCCAGAACCTAATGCCCCTGCTGGAAGGAAGGGCGTCCCACTCCGACCAC
GAGTTCCTCTTCCACTACTGTGGGGTCTATCTGCACACGGTCAGGTGGCATCAGAAGGAC
TGTGCAACTGTGTGGAAAGCTCATTATGTGACTCCTAAATTCTACCCTGAAGGAACAGGT
GCCTGCTATGGGAGTGGAATATGTTCATGTTCGGGGGATGTAACCTACCACGACCCACCA
CTCCTCTTTGACATCTCAAGAGACCCTTCAGAAGCCCTTCCACTGAACCCTGACAATGAG
CCATTATTTGACTCCGTGATCAAAAAGATGGAGGCAGCCATAAGAGAGCATCGTAGGACA
CTAACACCTGTCCCACAGCAGTTCTCTGTGTTCAACACAATTTGGAAACCATGGCTGCAG
CCTTGCTGTGGGACCTTCCCCTTCTGTGGGTGTGACAAGGAAGATGACATCCTTCCCATG
GCTCCCTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
AY875940

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_7_Locus:
Xp22.33

# Macromolecular_Interacting_Partner_7_SNPs:
rs5939407; rs1454503; rs5982981; rs5939151; rs7878711; rs11152555; rs5939406; rs10871873; rs5939153; rs1551377; rs5939409; rs10871872; rs5939411; rs11797171; rs5939154; rs5982633; rs1454502; rs768941; rs7876301; rs5982984; rs5982634; rs7055072; rs5982982; rs5939410; rs5939405; rs7887666; rs1966877; rs7054514; rs5982631; rs5982630; rs5982632; rs4892830; rs5939155; rs5939403; rs12008721; rs12837493; rs35887067; rs3032484; rs5982988; rs34159019; rs5901217; rs12388937; rs35728409; rs7056073; rs12686935; rs6642089; rs34048384; rs10640106; rs5939404; rs1966876; rs1470938; rs5901218; rs7474014; rs34665753; rs5939152; rs34208985; rs5982985; rs768942; rs12833818; rs5982979; rs10609103; rs7051141; rs7054744; rs5982986; rs34659109; rs35192045; rs34062456; rs11357665; rs10605342; rs12389115; rs3032483; rs10606600; rs34748096; rs34062105; rs5982987; rs5982980; rs34211469; rs35756988; rs34714250; rs5982983; rs4892829; rs34745750; rs6642088; rs7892360; rs34081662; rs36092856; rs12863026; rs12115962; rs12391596; rs12837470; rs12843021; rs12856832; rs17051460; rs17051461; rs17051467; rs1860008; rs2368456; rs4892912; rs5939158; rs5982635; rs6642092; rs6655048; rs7889997

# Macromolecular_Interacting_Partner_7_General_References:
Not Available

# Macromolecular_Interacting_Partner_7_References:
10731634; 11277533; 11507654; 11992772

# Macromolecular_Interacting_Partner_8_ID:
8181

# Macromolecular_Interacting_Partner_8_Name:
17-beta hydroxysteroid dehydrogenase 13 precursor

# Macromolecular_Interacting_Partner_8_Synonyms:
Short- chain dehydrogenase/reductase 9

# Macromolecular_Interacting_Partner_8_Gene_Name:
HSD17B13

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>17beta hydroxysteroid dehydrogenase 13 precursor
MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ
SILVLWDINK
RGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVN
NAGTVYPADLLSTKDEEITKT
FEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEG
IPYLIPYCSSKFAAVGFHRGLTSELQALGKTG
IKTSCLCPVFVNTGFTKNPSTRLWPVL
ETDEVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAI
LNRMQNIQFEAVVGHK
IKMK

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
300

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
33656

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
9.32

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Lipid transport and metabolism 

# Macromolecular_Interacting_Partner_8_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00106:adh_short

# Macromolecular_Interacting_Partner_8_Signals:
1-19

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
29824870

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
DHB13_HUMAN (Q7Z5P4)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
HSD17B13

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
HSD17B13

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:18685

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Secreted protein (Potential)

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>903 bp

ATGAACATCATCCTAGAAATCCTTCTGCTTCTGATCACCATCATCTACTCCTACTTGGA
GTCGTTGGTGA
AGTTTTTCATTCCTCAGAGGAGAAAATCTGTGGCTGGGGAGATTGTTC
TCATTACTGGAGCTGGGCATGG
AATAGGCAGGCAGACTACTTATGAATTTGCAAAACGA
CAGAGCATATTGGTTCTGTGGGATATTAATAAG
CGCGGTGTGGAGGAAACTGCAGCTGA
GTGCCGAAAACTAGGCGTCACTGCGCATGCGTATGTGGTAGACT
GCAGCAACAGAGAAG
AGATCTATCGCTCTCTAAATCAGGTGAAGAAAGAAGTGGGTGATGTAACAATCGT
GGTG
AATAATGCTGGGACAGTATATCCAGCCGATCTTCTCAGCACCAAGGATGAAGAGATTACC
AAGACA
TTTGAGGTCAACATCCTAGGACATTTTTGGATCACAAAAGCACTTCTTCCATC
GATGATGGAGAGAAATC
ATGGCCACATCGTCACAGTGGCTTCAGTGTGCGGCCACGAAG
GGATTCCTTACCTCATCCCATATTGTTC
CAGCAAATTTGCCGCTGTTGGCTTTCACAGA
GGTCTGACATCAGAACTTCAGGCCTTGGGAAAAACTGGT
ATCAAAACCTCATGTCTCTG
CCCAGTTTTTGTGAATACTGGGTTCACCAAAAATCCAAGCACAAGATTAT
GGCCTGTAT
TGGAGACAGATGAAGTCGTAAGAAGTCTGATAGATGGAATACTTACCAATAAGAAAATGA
T
TTTTGTTTCATCGTATATCAATATCTTTCTGAGACTACAGAAGTTTCTTCCTGAACGC
GCCTCAGCGATT
TTAAATCGTATGCAAAATATTCAATTTGAAGCAGTGGTTGGCCACAA
AATCAAAATGAAATGA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
AY186249

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_8_Locus:
4q22.1

# Macromolecular_Interacting_Partner_8_SNPs:
rs11735092; rs11945520; rs7663544; rs11727374; rs6531973; rs6814819; rs6833257; rs6828094; rs6531974; rs6531976; rs6828253; rs6850509; rs7676494; rs9992651; rs10433937; rs6531975; rs7692397; rs6531972; rs10022237; rs6850131; rs6531971; rs7698406; rs13130041; rs6834947; rs7671726; rs7662471; rs13142110; rs6820688; rs10433879; rs35075057; rs13118664; rs13112695; rs7671557; rs11726577; rs6850337; rs7667669; rs7655805; rs4305486; rs7678047; rs7682602; rs7655477; rs35784587; rs7685519; rs13106540; rs7686034; rs35434493; rs33934116; rs7698974; rs10030142; rs13139110; rs36015293; rs11734597; rs10681357; rs34709540; rs11438143; rs13136048; rs28514292; rs35721800; rs28738839; rs28373057; rs34419567; rs13135774; rs10651284; rs7671509; rs13111534; rs13125803; rs4693814; rs36045121; rs11734605; rs6827608; rs13122286; rs12511022; rs7692507; rs4693815; rs34678369; rs9995237; rs10643101; rs10470884; rs11726780; rs13143052; rs34080539; rs10527962; rs34842310; rs6828226; rs28636836; rs6531970; rs13119654; rs34403869; rs10686977; rs28456144; rs11450285; rs34221422; rs13102451; rs13133311; rs13139418; rs13150834; rs4079; rs4089; rs4271972; rs6817297; rs6832013; rs6832102; rs6840298; rs7668476; rs7668655; rs7669798; rs7674658; rs7681829; rs9647458

# Macromolecular_Interacting_Partner_8_General_References:
12975309

# Macromolecular_Interacting_Partner_8_References:
10220871; 16394181

End of HMDB00145

Beginning of HMDB00148
# Accession_No:
HMDB00148

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-17 17:20:38

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
L-Glutamic acid

# Description:
Glutamic acid (Glu), also referred to as glutamate (the anion), is one of the 20 proteinogenic amino acids. It is not among the essential amino acids. Glutamate is a key molecule in cellular metabolism. In humans, dietary proteins are broken down by digestion into amino acids, which serves as metabolic fuel or other functional roles in the body. Glutamate is the most abundant fast excitatory neurotransmitter in the mammalian nervous system. At chemical synapses, glutamate is stored in vesicles. Nerve impulses trigger release of glutamate from the pre-synaptic cell. In the opposing post-synaptic cell, glutamate receptors, such as the NMDA receptor, bind glutamate and are activated. Because of its role in synaptic plasticity, it is believed that glutamic acid is involved in cognitive functions like learning and memory in the brain. Glutamate transporters are found in neuronal and glial membranes. They rapidly remove glutamate from the extracellular space. In brain injury or disease, they can work in reverse and excess glutamate can accumulate outside cells. This process causes calcium ions to enter cells via NMDA receptor channels, leading to neuronal damage and eventual cell death, and is called excitotoxicity. The mechanisms of cell death include:     * Damage to mitochondria from excessively high intracellular Ca2+.     * Glu/Ca2+-mediated promotion of transcription factors for pro-apoptotic genes, or downregulation of transcription factors for anti-apoptotic genes. Excitotoxicity due to glutamate occurs as part of the ischemic cascade and is associated with stroke and diseases like amyotrophic lateral sclerosis, lathyrism, and Alzheimer's disease. Glutamic acid has been implicated in epileptic seizures. Microinjection of glutamic acid into neurons produces spontaneous depolarization around one second apart, and this firing pattern is similar to what is known as paroxysmal depolarizing shift in epileptic attacks. This change in the resting membrane potential at seizure foci could cause spontaneous opening of voltage activated calcium channels, leading to glutamic acid release and further depolarization. (http://en.wikipedia.org/wiki/Glutamic_acid)

# Synonyms:
(2S)-2-Aminopentanedioate; (2S)-2-Aminopentanedioic acid; (S)-(+)-Glutamate; (S)-(+)-Glutamic acid; (S)-2-Aminopentanedioate; (S)-2-Aminopentanedioic acid; (S)-Glutamate; (S)-Glutamic acid; 1-Aminopropane-1,3-dicarboxylate; 1-Aminopropane-1,3-dicarboxylic acid; 1-amino-propane-1,3-dicarboxylate; 1-amino-propane-1,3-dicarboxylic acid; 2-Aminoglutarate; 2-Aminoglutaric acid; 2-Aminopentanedioate; 2-Aminopentanedioic acid; Aciglut; E; Glusate; Glutacid;  Glutamicol; Glutamidex; Glutaminate; Glutaminic acid; Glutaminol; Glutaton; L-(+)-Glutamate; L-(+)-Glutamic acid; L-Glutamate; L-Glutaminate; L-Glutaminic acid; L-a-Aminoglutarate; L-a-Aminoglutaric acid; L-glu; a-Aminoglutarate; a-Aminoglutaric acid; a-Glutamate; a-Glutamic acid; aminoglutarate; aminoglutaric acid; glt; glu; glut; L-alpha-Aminoglutarate; L-alpha-Aminoglutaric acid; alpha-Aminoglutarate; alpha-Aminoglutaric acid; alpha-Glutamate; alpha-Glutamic acid

# Chemical_IUPAC_Name:
2-aminopentanedioic acid

# Chemical_Formula:
C5H9NO4

# Chemical_Structure:
tbl_chemical:::HMDB00148_ZOOM.png:::119283217036044265

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00148_THUMB.png:::119283216878494660

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids; Nitrogenous Compounds

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid; alpha-aminoacid

# Taxonomy_Biofunction:
Component of Alanine and aspartate metabolism; Component of Aminoacyl-tRNA biosynthesis; Component of Aminosugars metabolism; Component of Arginine and proline metabolism; Component of beta-Alanine metabolism; Component of Butanoate metabolism; Component of Cyanoamino acid metabolism; Component of Cysteine metabolism; Component of D-Glutamine and D-glutamate metabolism; Component of Folate biosynthesis; Component of Glutamate metabolism; Component of Glutathione metabolism; Component of Glycine, serine and threonine metabolism; Component of Lysine biosynthesis; Component of Nitrogen metabolism; Component of Novobiocin biosynthesis; Component of Pantothenate and CoA biosynthesis; Component of Peptidoglycan biosynthesis; Component of Phenylalanine metabolism; Component of Phenylalanine, tyrosine and tryptophan biosynthesis; Component of Porphyrin and chlorophyll metabolism; Component of Prostaglandin and leukotriene metabolism; Component of Purine metabolism; Component of Pyrimidine metabolism; Component of Selenoamino acid metabolism; Component of Taurine and hypotaurine metabolism; Component of Tyrosine metabolism; Component of Valine, leucine and isoleucine biosynthesis; Component of Vitamin B6 metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
147.05316

# Molecular_Weight_Avg:
147.12926

# Smiles_String_isomeric:
N[C@@H](CCC(O)=O)C(O)=O

# Smiles_String_canonical:
NC(CCC(O)=O)C(O)=O

# KEGG_Compound_ID:
C00025

# BioCyc_ID:
GLT

# PubChem_CID:
33032

# PubChem_SID:
7847075; 841758; 822518; 10322368; 8172949; 826975; 7887829; 834778; 7852151; 585818; 11538435; 11528393; 822932; 823119; 11110117; 854502; 11113412; 174937; 11538992; 824406; 854468; 828108; 584409; 11538061; 8026293; 820617; 822724; 10318048; 11110113; 825538; 627126; 3327; 10322655; 825074; 7979423; 822192; 7887923; 820094; 838613; 10527679; 11110137; 8026291; 822187; 8143737; 584833; 854467; 584410

# OMIM_ID:
600111

# Metagene_ID:
Hyperornithinemia WITH Gyrate Atrophy (hoga): 258870; Dicarboxylic Aminoaciduria. Glutamate-aspartate Transport Defect: 222730

# BiGG_ID:
33561

# Wikipedia_ID:
E

# METLIN_ID:
5174

# Ref_ID:
3162516; 15135231; 15911239; 11304775; 12297216; 14992292; 8579834; 15592994; 1851687; 12097436; 2453224; 14749132; 6696735; 9004939; 12869660; 16400059; 9465528; 12073073; 10052870; 15596234

# ChEBI_ID:
16015

# CAS_Registry_Number:
56-86-0

# InChI:
InChI=1/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

# Synthesis_Reference:
Tertiary phosphines. IV. Use of phosphine imines in causing the introduction of primary amino groups.     Horner, L.; Gross, A.    Ann.  (1955),  591  117-34.

# Melting_Point:
Not Available

# Melting_Point_predicted:
39.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
8.57 mg/mL [BULL,HB et al. (1978)]

# H2O_Solubility_Predicted:
80.6 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
-3.69 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-3.54 [Predicted by ALOGPS]; -3.3 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00148_MSDS_1.html:::222565933843908>>>tbl_chemical:::HMDB00148_MSDS_2.pdf:::271535866022512

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Glutamic_acid.mol:::1132723810015519083

# SDF_File_[Text]:
tbl_chemical:::HMDB00148.sdf:::119283216567691812

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00148.pdb:::119283216740835421

# PDB_ID:
1BGV

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041007_P00_02_HW_1DP_PRESAT_expanded_2.gif:::114460738763792432

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041007_P00_02_HW_1DP_presat.zip:::1177710649153166070

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041007_P00_02_HW_1DP_Assigned.png:::117863944951550615

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041007_P00_02_HW_1DP_presat.png:::114807530614583600

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041007_P00_02_HW_1DP_PRESAT_1.zip:::1144607821070472

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
tbl_cnmr:::041007_P00_02_HW_1DC_68.jpg:::114470902764389263

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041007_P00_02_HW_1DC_68.zip:::11447090276837668

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041007_P00_02_HW_1DC_68_Assigned.jpg:::114565946265014518

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041007_P00_02_HW_2DHSQC_229.jpg:::11456595614927470

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041007_P00_02_HW_2DHSQC_229.zip:::114565956150169689

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041007_P00_02_HW_2DHSQC_229_Assigned.jpg:::114565956165080762

# Predicted_H_NMR_Spectrum:
tbl_chemical:::L-Glutamic_acid.gif:::115325130230332200

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00148_peaks.txt:::1156309575136284743

# Predicted_C_NMR_Spectrum:
tbl_chemical:::L-Glutamic_acid_C.gif:::115325130232420906

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00148_peaks.txt:::1156310765016897906

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00148L.png:::117555263461440722; Medium Energy:tbl_ms:::HMDB00148M.png:::117555268758921138; High Energy:tbl_ms:::HMDB00148H.png:::117555271968586382

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000037.png:::116890823754664523

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000037.txt:::116890823754630044

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000037.png:::116890823728133593

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000037.txt:::116890823754621114

# Cellular_Location:
Cytoplasm (Predicted from LogP); endoplasmic reticulum; Extracellular; lysosome; mitochondria

# Tissue_Location:
Adipose Tissue; Adrenal Medulla; Epidermis; Fibroblasts; Intestine; Kidney; Muscle; Myelin; Nerves; Neurons; Pancreas; Placenta; Platelet; Skeletal Muscle; Spleen; Stratum Corneum

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Cellular Cytoplasm; Saliva; Urine

# Concentration_[Normal]:
Urine	1.711 (0.329-3.092)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Blood	24.0 (9.0-39.0)	umol/L	Adult:>18_yrs_old	Both	Normal	12297216
Blood	65.0 +/- 35.0	umol/L	Newborn:0-30_days_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	35.0 +/- 14.0	umol/L	Children:1-13_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	37.0 +/- 14.0	umol/L	Children:1-13_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	60.0 +/- 16.0	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	46.0 +/- 13.0	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	226.0 +/- 85.0	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 93. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	214.0 +/- 71.0	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 93. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	1.8 +/- 0.7	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	0.34 +/- 0.14	umol/L	Adult:>18_yrs_old	N/A	Normal	2453224
Cerebrospinal_Fluid(CSF)	32.6 +/- 6.9	umol/L	Adult:>18_yrs_old	N/A	Normal	15911239
Cerebrospinal_Fluid(CSF)	0.62 (0.18-1.15)	umol/L	Adult:>18_yrs_old	Both	Normal	9004939
Saliva	>10	umol/L	Adult:>18_yrs_old	Both	Normal	12097436
Cellular_Cytoplasm	1400 (1200-1600)	umol/L	Adult:>18_yrs_old	Both	Normal	8579834


# Concentration_[Abnormal]:
Blood	32.7 +/- 18.0	umol/L	Adult:>18_yrs_old	Male	Schizophrenic patients (Men)	2480613
Blood	34.7 +/- 26.0	umol/L	Adult:>18_yrs_old	Both	Schizophrenic patients (Women)	2480613
Blood	29.8 (27.6-32.0)	umol/L	Adult:>18_yrs_old	Both	Refractory localization-related epilepsy (RLE)	14992292
Blood	39.7 (36.5-42.9)	umol/L	Adult:>18_yrs_old	Both	Juvenile myoclonic epilepsy (JME)	14992292
Blood	56.6 (44.6-68.6)	umol/L	Adult:>18_yrs_old	Both	Acute seizures	14992292
Blood	170	umol/L	Adult:>18_yrs_old	Both	Diabetes	6696735
Cerebrospinal_Fluid(CSF)	26.8 +/- 5.9	umol/L	N/A	N/A	leukemia	15911239
Cerebrospinal_Fluid(CSF)	23.6 +/- 8.5	umol/L	N/A	N/A	leukemia with CNS disease	15911239
Cellular_Cytoplasm	2500 (2100-2900)	umol/L	Adult:>18_yrs_old	Both	Anoxia	8579834


# Associated_Disorders:
Acute seizures; Amyotrophic lateral sclerosis (ALS); Anoxia; Aseptic meningitis; Cerebral Hypoxia; Diabetes; Dicarboxylic Aminoaciduria; Glutamate-Aspartate Transport Defect; Juvenile Myoclonic Epilepsy (JME); leukemia; leukemia with CNS disease; Migraine; Refractory Localization-Related Epilepsy (RLE); Schizophrenic patients (Men); Schizophrenic patients (Women); Stroke; Tuberculous meningitis

# Pathway_Names:
Porphyrin and chlorophyll metabolism;Aminosugars metabolism;Glutathione metabolism;Prostaglandin and leukotriene metabolism;One carbon pool by folate;Folate biosynthesis;Alanine and aspartate metabolism;Vitamin B6 metabolism;Lysine degradation;Valine, leucine and isoleucine degradation;Valine, leucine and isoleucine biosynthesis;Pantothenate and CoA biosynthesis;Butanoate metabolism;Purine metabolism;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
;;;;;;Aspartate_and_Alanine_metabolism.jpg;;Lysine_degradation.jpg;valine,leucine,and_isoleucine_degradation.jpg;Valine,leucine,and_isoleucine_biosynthesis.jpg;;;Purine_Synthesis.jpg;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00860;map00530;map00480;map0059;map00670;map00790;map00252;map00750;map00310;map00280;map00290;map00770;map00650;map00230;map00280;map00280

# Pathway_Graphs:
;;;;;;Aspartate_and_Alanine_metabolism_Graph.jpg;;Lysine_degradation_Graph.jpg;valine,leucine,and_isoleucine_degradation_Graph.jpg;Valine,leucine,and_isoleucine_biosynthesis_Graph.jpg;;;Purine_Synthesis_Graph.jpg;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
;;;;;;Aspartate_and_Alanine_metabolism.xml;;Lysine_degradation.xml;valine,leucine,and_isoleucine_degradation.xml;Valine,leucine,and_isoleucine_biosynthesis.xml;;;Purine_Synthesis.xml;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5949

# Metabolic_Enzyme_1_Name:
CTP synthase 1

# Metabolic_Enzyme_1_Synonyms:
UTP--ammonia ligase 1; CTP synthetase 1

# Metabolic_Enzyme_1_Gene_Name:
CTPS

# Metabolic_Enzyme_1_Protein_Sequence:
>CTP synthase 1
MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFV
LDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDA
IQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHV
SLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQ
VICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCS
IALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSADLEPITSQEEPVRYHEAWQK
LCSAHGVLVPGGFGVRGTEGKIQAIAWARNQKKPFLGVCLGMQLAVVEFSRNVLGWQDAN
STEFDPTTSHPVVVDMPEHNPGQMGGTMRLGKRRTLFQTKNSVMRKLYGDADYLEERHRH
RFEVNPVWKKCLEEQGLKFVGQDVEGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPY
FGLLLASVGRLSHYLQKGCRLSPRDTYSDRSGSSSPDSEITELKFPSINHD

# Metabolic_Enzyme_1_Number_of_Residues:
591

# Metabolic_Enzyme_1_Molecular_Weight:
66691

# Metabolic_Enzyme_1_Theoretical_pI:
6.42

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  CTP synthase activity
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  pyrimidine nucleotide metabolism
Process:  pyrimidine nucleotide biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

# Metabolic_Enzyme_1_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_1_Reaction:
ATP + UTP + NH3 = ADP + phosphate + CTP

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF06418:CTP_synth_N;
PF00117:GATase

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 6.3.4.2

# Metabolic_Enzyme_1_GenBank_ID_Protein:
30293

# Metabolic_Enzyme_1_SwissProt_ID:
PYRG1_HUMAN (P17812)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
CTPS

# Metabolic_Enzyme_1_Geneatlas_id:
CTPS

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2519

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1776 bp
ATGAAGTACATTCTGGTTACTGGTGGTGTTATATCAGGAATTGGAAAAGGAATCATTGCC
AGCAGTGTGGGCACAATACTCAAGTCATGTGGTTTACATGTAACTTCAATCAAAATTGAC
CCCTACATTAACATTGATGCAGGAACATTCTCTCCTTATGAGCATGGTGAGGTTTTTGTG
CTGGATGATGGTGGGGAAGTAGACCTTGACCTGGGTAACTATGAGCGGTTCCTTGACATC
CGCCTCACCAAGGACAATAATCTGACCACTGGAAAGATATACCAGTATGTCATTAACAAG
GAACGGAAAGGAGATTACTTGGGGAAAACTGTCCAAGTTGTCCCTCATATCACAGATGCA
ATCCAGGAGTGGGTGATGAGACAGGCGTTAATACCTGTAGATGAAGATGGCCTGGAACCT
CAAGTGTGTGTTATTGAGCTTGGTGGAACCGTGGGGGACATAGAAAGCATGCCCTTTATT
GAGGCCTTCCGTCAGTTCCAATTCAAGGTCAAAAGAGAGAACTTTTGTAACATCCACGTC
AGTCTAGTTCCCCAGCCAAGTTCAACAGGGGAACAGAAGACTAAACCTACCCAGAATAGT
GTTCGGGAACTTAGAGGACTTGGGCTTTCCCCAGATCTGGTTGTATGCAGGTGCTCAAAT
CCACTTGACACATCAGTGAAGGAGAAAATATCAATGTTCTGCCATGTTGAGCCTGAACAA
GTGATCTGTGTCCACGATGTCTCATCCATCTACCGAGTCCCCTTGTTGTTAGAGGAGCAA
GGGGTTGTAGATTATTTTCTTCGAAGACTTGACCTTCCTATTGAGAGGCAGCCAAGAAAA
ATGCTGATGAAATGGAAAGAGATGGCTGACAGATATGATCGCTTGCTGGAGACCTGCTCT
ATTGCCCTTGTGGCGAAATACACCGAGTTCTCAGACTCCTATGCCTCTGTCATTAAGGCT
CTGGAGCATTCTGCACTGGCCATCAACCACAAATTGGAAATCAAGTACATAGATTCTGCG
GACTTGGAGCCCATCACCTCGCAAGAAGAGCCCGTGCGCTACCACGAAGCTTGGCAGAAG
CTCTGTAGTGCTCATGGAGTGCTGGTTCCAGGAGGATTTGGTGTTCGAGGAACAGAAGGA
AAAATCCAAGCAATTGCCTGGGCTCGGAATCAGAAAAAGCCTTTTTTGGGCGTGTGCTTA
GGGATGCAGTTGGCAGTGGTTGAATTCTCAAGAAACGTGCTGGGATGGCAAGATGCCAAT
TCTACAGAGTTTGACCCTACGACCAGTCATCCCGTGGTCGTAGACATGCCAGAACACAAC
CCAGGGCAGATGGGCGGAACCATGAGGCTGGGCAAGAGGAGAACCCTGTTCCAGACCAAG
AACTCAGTCATGAGGAAACTCTATGGAGACGCAGACTACTTGGAAGAGAGGCACCGCCAC
CGATTTGAGGTGAATCCAGTCTGGAAAAAGTGTTTGGAAGAACAAGGCTTGAAGTTTGTT
GGCCAAGATGTTGAAGGAGAGAGAATGGAAATTGTGGAGTTAGAAGATCATCCCTTTTTT
GTTGGGGTTCAGTACCACCCTGAGTTCCTGTCCAGGCCTATCAAGCCCTCCCCACCATAC
TTTGGCCTCCTCCTGGCCTCTGTGGGGCGGCTCTCACATTACCTCCAGAAAGGCTGCAGG
CTCTCACCCAGGGACACCTATAGTGACAGGAGTGGAAGCAGCTCCCCTGACTCTGAAATC
ACCGAACTGAAGTTTCCATCAATAAATCATGACTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X52142

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_1_Locus:
1p34.1

# Metabolic_Enzyme_1_SNPs:
rs4363414; rs16827810; rs7546898; rs11577910; rs11209315; rs7512775; rs12410005; rs12410096; rs12718433; rs11209342; rs12408576; rs4132438; rs6600363; rs4132440; rs7523029; rs6600362; rs7535802; rs11209331; rs3922676; rs4364871; rs7537689; rs4453027; rs12047657; rs12044786; rs35044078; rs4430318; rs12735455; rs12743340; rs13376450; rs12731155; rs4132439; rs12144160; rs11209347; rs12047078; rs12023079; rs2897231; rs2897230; rs12729920; rs3935871; rs35240983; rs17856308; rs11541594; rs36007898; rs34761170; rs5030799; rs33963815; rs11316628; rs12736067; rs5030801; rs35846227; rs34730648; rs5030800; rs7543690; rs11209312; rs4130828; rs12135912; rs6675122; rs12145744; rs12749196; rs34316011; rs34538426; rs12135364; rs35080169; rs34043964; rs35160190; rs12119675; rs4660497; rs5773721; rs35156226; rs35281195; rs28469640; rs11209349; rs12027691; rs4660496; rs12739052; rs4660182; rs11580414; rs35368773; rs34472412; rs41308258; rs11343566; rs28401673; rs34502739; rs12748235; rs6675165; rs12061505; rs34406683; rs4548429; rs36057096; rs41268101; rs12738189; rs12724936; rs12090358; rs1892553; rs12079825; rs12132595; rs3206609; rs34209541; rs10789262; rs11209361; rs11209363; rs1129661; rs1138293; rs11579483; rs11579485; rs11584051; rs12033893; rs12033917; rs12033920; rs12121539; rs12736566; rs17357905; rs17357954; rs34386830; rs35405087; rs36084778; rs3738368; rs3738369; rs4360513; rs4440845; rs4660498; rs6661890; rs6674450; rs6685430; rs7534059

# Metabolic_Enzyme_1_General_References:
2113467

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5839

# Metabolic_Enzyme_2_Name:
Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase

# Metabolic_Enzyme_2_Synonyms:
Glutamate--tRNA ligase; Prolyl-tRNA synthetase; Proline--tRNA ligase]

# Metabolic_Enzyme_2_Gene_Name:
EPRS

# Metabolic_Enzyme_2_Protein_Sequence:
>Bifunctional aminoacyltRNA synthetase Includes: GlutamyltRNA synthetase
MEHTEIDHWLEFSATKLSSCDSFTSTINELNHCLSLRTYLVGNSLSLADLCVWATLKGNA
AWQEQLKQKKAPVHVKRWFGFLEAQQAFQSVGTKWDVSTTKARVAPEKKQDVGKFVELPG
AEMGKVTVRFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEKEDFEKVI
LEDVAMLHIKPDQFTYTSDHFETIMKYAEKLIQEGKAYVDDTPAEQMKAEREQRIESKHR
KNPIEKNLQMWEEMKKGSQFGHSCCLRAKIDMSSNNGCMRDPTLYRCKIQPHPRTGNKYN
VYPTYDFACPIVDSIEGVTHALRTTEYHDRDEQFYWIIEALGIRKPYIWEYSRLNLNNTV
LSKRKLTWFVNEGLVDGWDDPRFPTVRGVLRRGMTVEGLKQFIAAQGSSRSVVNMEWDKI
WAFNKKVIDPVAPRYVALLKKEVIPVNVPEAQEEMKEVAKHPKNPEVGLKPVWYSPKVFI
EGADAETFSEGEMVTFINWGNLNITKIHKNADGKIISLDAKFNLENKDYKKTTKVTWLAE
TTHALPIPVICVTYEHLITKPVLGKDEDFKQYVNKNSKHEELMLGDPCLKDLKKGDIIQL
QRRGFFICDQPYEPVSPYSCKEAPCVLIYIPDGHTKEMPTSGSKEKTKVEATKNETSAPF
KERPTPSLNNNCTTSEDSLVLYNRVAVQGDVVRELKAKKAPKEDVDAAVKQLLSLKAEYK
EKTGQEYKPGNPPAEIGQNISSNSSASILESKSLYDEVAAQGEVVRKLKAEKSPKAKINE
AVECLLSLKAQYKEKTGKEYIPGQPPLSQSSDSSPTRNSEPAGLETPEAKVLFDKVASQG
EVVRKLKTEKAPKDQVDIAVQELLQLKAQYKSLIGVEYKPVSATGAEDKDKKKKEKENKS
EKQNKPQKQNDGQRKDPSKNQGGGLSSSGAGEGQGPKKQTRLGLEAKKEENLADWYSQVI
TKSEMIEYHDISGCYILRPWAYAIWEAIKDFFDAEIKKLGVENCYFPMFVSQSALEKEKT
HVADFAPEVAWVTRSGKTELAEPIAIRPTSETVMYPAYAKWVQSHRDLPIKLNQWCNVVR
WEFKHPQPFLRTREFLWQEGHSAFATMEEAAEEVLQILDLYAQVYEELLAIPVVKGRKTE
KEKFAGGDYTTTIEAFISASGRAIQGGTSHHLGQNFSKMFEIVFEDPKIPGEKQFAYQNS
WGLTTRTIGVMTMVHGDNMGLVLPPRVACVQVVIIPCGITNALSEEDKEALIAKCNDYRR
RLLSVNIRVRADLRDNYSPGWKFNHWELKGVPIRLEVGPRDMKSCQFVAVRRDTGEKLTV
AENEAETKLQAILEDIQVTLFTRASEDLKTHMVVANTMEDFQKILDSGKIVQIPFCGEID
CEDWIKKTTARDQDLEPGAPSMGAKSLCIPFKPLCELQPGAKCVCGKNPAKYYTLFGRSY


# Metabolic_Enzyme_2_Number_of_Residues:
1440

# Metabolic_Enzyme_2_Molecular_Weight:
163028

# Metabolic_Enzyme_2_Theoretical_pI:
7.75

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  proline-tRNA ligase activity
Function:  glutamate-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  prolyl-tRNA aminoacylation
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  glutamyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  protein biosynthesis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_2_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_2_Specific_Function:
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)

# Metabolic_Enzyme_2_Pathway:
map00251  Glutamate metabolism;
 map00860  Porphyrin and chlorophyll metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_2_Reaction:
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF03129:HGTP_anticodon;
PF09180:ProRS-C_1;
PF00749:tRNA-synt_1c;
PF03950:tRNA-synt_1c_C;
PF00587:tRNA-synt_2b;
PF00458:WHEP-TRS

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 6.1.1.17;EC 6.1.1.15

# Metabolic_Enzyme_2_GenBank_ID_Protein:
31958

# Metabolic_Enzyme_2_SwissProt_ID:
SYEP_HUMAN (P07814)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
EPRS

# Metabolic_Enzyme_2_Geneatlas_id:
EPRS

# Metabolic_Enzyme_2_hgnc_id:
HGNC:3418

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>4323 bp
ATGGAACATACTGAGATTGATCACTGGTTGGAGTTCAGTGCTACAAAATTATCTTCATGT
GATTCCTTTACTTCTACAATTAATGAACTCAATCATTGCCTGTCTCTGAGAACATACTTA
GTTGGAAACTCCTTGAGTTTAGCAGATTTATGTGTTTGGGCCACCCTAAAAGGAAATGCT
GCCTGGCAAGAACAGTTGAAACAGAAGAAAGCTCCAGTTCATGTAAAACGTTGGTTTGGC
TTTCTTGAAGCCCAGCAGGCCTTCCAGTCAGTAGGTACCAAGTGGGATGTTTCAACAACC
AAAGCTCGAGTGGCACCTGAGAAAAAGCAAGATGTTGGGAAATTTGTTGAGCTTCCAGGT
GCGGAGATGGGAAAGGTTACCGTCAGATTTCCTCCAGAGGCCAGTGGTTACTTACACATT
GGGCATGCAAAAGCTGCTCTTCTGAACCAGCACTACCAGGTTAACTTTAAAGGGAAACTG
ATCATGAGATTTGATGACACAAATCCTGAAAAAGAAAAGGAAGATTTTGAGAAGGTTATC
TTGGAAGATGTTGCAATGTTGCATATCAAACCAGATCAATTTACTTATACTTCGGATCAT
TTTGAAACTATAATGAAGTATGCAGAGAAGCTAATTCAAGAAGGGAAGGCTTATGTGGAT
GATACTCCTGCTGAACAGATGAAAGCAGAACGTGAGCAGAGGATAGAATCTAAACATAGA
AAAAACCCTATTGAGAAGAATCTACAAATGTGGGAAGAAATGAAAAAAGGGAGCCAGTTT
GGTCACTCCTGTTGTTTGCGAGCAAAAATTGACATGAGTAGTAACAATGGATGCATGAGA
GATCCAACCCTTTATCGCTGCAAAATTCAACCACATCCAAGAACTGGAAATAAATACAAT
GTTTATCCAACATATGATTTTGCCTGCCCCATAGTTGACAGCATCGAAGGTGTTACACAT
GCCCTGAGAACAACAGAATACCATGACAGAGATGAGCAGTTTTACTGGATTATTGAAGCT
TTAGGCATAAGAAAACCATATATTTGGGAATATAGTCGGCTAAATCTCAACAACACAGTG
CTATCCAAAAGAAAACTCACATGGTTTGTCAATGAAGGACTAGTAGATGGATGGGATGAC
CCAAGATTTCCTACGGTTCGTGGTGTACTGAGAAGAGGGATGACAGTTGAAGGACTGAAA
CAGTTTATTGCTGCTCAGGGCTCCTCACGTTCAGTCGTGAACATGGAGTGGGACAAAATC
TGGGCGTTTAACAAAAAGGTTATTGACCCAGTGGCTCCACGATATGTTGCATTACTGAAG
AAAGAAGTGATCCCAGTGAATGTACCTGAAGCTCAGGAGGAGATGAAAGAAGTAGCCAAA
CACCCAAAGAATCCTGAGGTTGGCTTGAAGCCTGTGTGGTATAGTCCCAAAGTTTTCATT
GAAGGTGCTGATGCAGAGACTTTTTCGGAGGGTGAGATGGTTACATTTATAAATTGGGGC
AACCTCAACATTACAAAAATACACAAAAATGCAGATGGAAAAATCATATCTCTTGATGCA
AAGTTTAATTTGGAAAACAAAGACTACAAGAAAACCACTAAGGTCACTTGGCTTGCAGAG
ACTACACATGCTCTTCCTATTCCAGTAATCTGTGTCACTTATGAGCACTTGATCACAAAG
CCAGTGCTAGGAAAAGACGAGGACTTTAAGCAGTATGTCAACAAGAACAGTAAGCATGAA
GAGCTAATGCTAGGGGATCCCTGCCTTAAGGATTTGAAAAAAGGAGATATTATACAACTC
CAGAGAAGAGGATTCTTCATATGTGATCAACCTTATGAACCTGTTAGCCCATATAGTTGC
AAGGAAGCCCCGTGTGTTTTGATATACATTCCTGATGGGCACACAAAGGAAATGCCAACA
TCAGGGTCAAAGGAAAAGACCAAAGTAGAAGCCACAAAAAATGAGACCTCTGCTCCTTTT
AAGGAAAGACCAACACCTTCTCTGAATAATAATTGTACTACATCTGAGGATTCCTTGGTC
CTTTACAATAGAGTGGCTGTTCAAGGAGATGTGGTTCGTGAATTAAAAGCCAAGAAAGCA
CCAAAGGAAGATGTAGATGCAGCTGTAAAACAGCTTTTGTCTTTGAAAGCTGAATATAAG
GAGAAAACTGGCCAGGAATATAAACCTGGAAACCCTCCTGCTGAAATAGGACAGAATATT
TCTTCTAATTCCTCAGCAAGTATTCTGGAAAGTAAATCTCTGTATGATGAAGTTGCTGCA
CAAGGGGAGGTGGTTCGTAAGCTAAAAGCTGAAAAATCCCCTAAGGCTAAAATAAATGAA
GCTGTAGAATGCTTACTGTCCCTGAAGGCTCAGTATAAAGAAAAAACTGGGAAGGAGTAC
ATACCTGGTCAGCCCCCATTATCTCAAAGTTCGGATTCAAGCCCAACCAGAAATTCTGAA
CCTGCTGGTTTAGAAACACCAGAAGCGAAAGTACTTTTTGACAAAGTAGCTTCTCAAGGG
GAAGTAGTTCGGAAACTTAAAACTGAAAAAGCCCCTAAGGATCAAGTAGATATAGCTGTT
CAAGAACTCCTTCAGCTAAAGGCACAGTACAAGTCTTTGATAGGAGTAGAGTATAAGCCT
GTGTCGGCCACTGGAGCTGAGGACAAAGATAAGAAGAAGAAAGAAAAAGAAAATAAATCT
GAAAAGCAGAATAAGCCTCAGAAACAAAATGATGGCCAAAGGAAAGACCCTTCTAAAAAC
CAAGGAGGTGGGCTCTCATCAAGTGGAGCAGGAGAAGGGCAGGGGCCTAAGAAACAGACC
AGGTTGGGTCTTGAGGCAAAAAAAGAAGAAAATCTTGCTGATTGGTATTCTCAGGTCATC
ACAAAGTCAGAAATGATTGAATACCATGACATAAGTGGCTGTTATATTCTTCGTCCCTGG
GCCTATGCCATTTGGGAAGCCATCAAGGACTTTTTTGATGCTGAGATCAAGAAACTTGGT
GTTGAAAACTGCTACTTCCCCATGTTTGTGTCTCAAAGTGCATTAGAGAAAGAGAAGACT
CATGTTGCTGACTTTGCCCCAGAGGTTGCTTGGGTTACAAGATCTGGCAAAACCGAGCTG
GCAGAACCAATTGCCATTCGTCCTACTAGTGAAACAGTAATGTATCCTGCATATGCAAAA
TGGGTACAATCACACAGAGACCTGCCCATCAAGCTCAATCAGTGGTGCAATGTGGTGCGT
TGGGAATTCAAGCATCCTCAGCCTTTCCTACGTACTCGTGAATTTCTTTGGCAGGAAGGG
CACAGTGCTTTTGCTACCATGGAAGAGGCAGCGGAAGAGGTCTTGCAGATACTTGACTTA
TATGCTCAGGTATATGAAGAACTCCTGGCAATTCCTGTTGTTAAAGGAAGAAAGACGGAA
AAGGAAAAATTTGCAGGAGGAGACTATACAACTACAATAGAAGCATTTATATCTGCTAGT
GGAAGAGCTATCCAGGGAGGAACATCACATCATTTAGGGCAGAATTTTTCCAAAATGTTT
GAAATCGTTTTTGAAGATCCAAAGATACCAGGAGAGAAGCAATTTGCCTATCAAAACTCC
TGGGGCCTGACAACTCGAACTATTGGTGTTATGACCATGGTTCATGGGGACAACATGGGT
TTAGTATTACCACCCCGTGTAGCATGTGTTCAGGTGGTGATTATTCCTTGTGGCATTACC
AATGCACTTTCTGAAGAAGACAAAGAAGCGCTGATTGCAAAATGCAATGATTATCGAAGG
CGATTACTCAGTGTTAACATCCGCGTTAGAGCTGATTTACGAGATAATTATTCTCCAGGT
TGGAAATTCAATCACTGGGAGCTCAAGGGAGTTCCCATTAGACTTGAAGTTGGGCCACGT
GATATGAAGAGCTGTCAGTTTGTAGCCGTCAGACGAGATACTGGAGAAAAGCTGACAGTT
GCTGAAAATGAGGCAGAGACTAAACTTCAAGCTATTTTGGAAGACATCCAGGTCACCCTT
TTCACAAGGGCTTCTGAAGACCTTAAGACTCATATGGTTGTGGCTAATACAATGGAAGAC
TTTCAGAAGATACTAGATTCTGGAAAGATTGTTCAGATTCCATTCTGTGGGGAAATTGAC
TGTGAGGACTGGATCAAAAAGACCACTGCCAGGGATCAAGATCTTGAACCTGGTGCTCCA
TCCATGGGAGCTAAAAGCCTTTGCATCCCCTTCAAACCACTCTGTGAACTGCAGCCTGGA
GCCAAATGTGTCTGTGGCAAGAACCCTGCCAAGTACTACACCTTATTTGGTCGCAGCTAC
TGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X54326

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_2_Locus:
1q41-q42

# Metabolic_Enzyme_2_SNPs:
rs5030752; rs2230301; rs35999099; rs34559775; rs5030751; rs1061160; rs5030754; rs36122746; rs1061242; rs1061248; rs6695781; rs2577138; rs1768672; rs2647468; rs1694601; rs2647447; rs2577144; rs2647459; rs2133194; rs2577150; rs1498393; rs2789797; rs2795314; rs2291838; rs2647435; rs2173403; rs2577145; rs1694576; rs2647462; rs2133195; rs2647469; rs1768673; rs2577137; rs1624678; rs2270710; rs2795310; rs2789816; rs2577136; rs2577159; rs7535767; rs1391566; rs10779396; rs7550249; rs1611961; rs7553236; rs2577149; rs2647430; rs6541124; rs10495143; rs3820457; rs3767671; rs6697041; rs6686451; rs1630386; rs2270711; rs10746395; rs1982985; rs7535773; rs12080607; rs6699641; rs6669906; rs1982986; rs2647470; rs2248479; rs2577148; rs2789798; rs4846612; rs2577146; rs2270712; rs1694577; rs2577140; rs2647445; rs2647461; rs2789793; rs10779393; rs6541120; rs1874811; rs2789794; rs2647464; rs7535650; rs2647463; rs6690630; rs3816993; rs2254494; rs2647457; rs2789817; rs2647454; rs2789796; rs11806631; rs2647420; rs2647428; rs2253521; rs2647458; rs2577141; rs1658227; rs2248466; rs2577158; rs6681471; rs2647436; rs2577156; rs2270709; rs7536968; rs2577163; rs10779395; rs11118485; rs3767661; rs4846611; rs2647479; rs11118490; rs7521682; rs6660598; rs2291836; rs2647429; rs3767670; rs1694599; rs2789809; rs6681055; rs1658226; rs2789813; rs12057663; rs10779394; rs10442684; rs12079635; rs2789810; rs11118488; rs10746396; rs2647453; rs10779391; rs7548397; rs2647467; rs3767669; rs2577142; rs10863524; rs10863528; rs11118486; rs10863523; rs7524619; rs7527659; rs1768665; rs10863521; rs7517173; rs4531301; rs2454326; rs12084571; rs3767675; rs1982987; rs7521388; rs2647478; rs7539385; rs6672134; rs17007062; rs10863527; rs4846610; rs6683340; rs7537559; rs7527749; rs12126940; rs12142009; rs2577147; rs2789799; rs4536003; rs949866; rs2789812; rs12022181; rs2789802; rs6703042; rs1768675; rs2647446; rs10863525; rs17007011; rs2248717; rs1612144; rs12032898; rs1557130; rs1846254; rs12032866; rs10442692; rs17006978; rs12123041; rs10863522; rs2647444; rs2647460; rs1694600; rs1768677; rs3767668; rs7537058; rs11118487; rs11118480; rs1768668; rs1622508; rs12073836; rs3767657; rs6674466; rs2647425; rs1566252; rs3820456; rs1768671; rs2789811; rs11118489; rs1768670; rs2647433; rs1768666; rs1498394; rs1874813; rs2486328; rs1874810; rs2577151; rs4379680; rs12069364; rs12726890; rs2248719; rs2577143; rs10863526; rs6692978; rs1982984; rs2245457; rs6681474; rs1694575; rs12048112; rs2577160; rs2789795; rs12140664; rs7545314; rs11811749; rs7531703; rs2577139; rs2647431; rs2789815; rs2647432; rs11118483; rs6690280; rs1874812; rs2577165; rs3767663; rs1768669; rs1874814; rs9988498; rs12117454; rs1846255; rs3767658; rs2647438; rs17007084; rs2647474; rs1768676; rs2647448; rs7534891; rs17006931; rs2577161; rs3816994; rs2027504; rs2030078; rs2030079; rs11118477; rs5030753; rs1063236; rs35325299; rs35055527; rs12144752; rs35578666; rs10987; rs41274786; rs2270713; rs2789804; rs5781162; rs12097519; rs11322745; rs28758924; rs10543617; rs35970586; rs2647424; rs35064558; rs35228542; rs34101093; rs12737399; rs35193743; rs12128043; rs12141517; rs3215088; rs1768667; rs35845125; rs12080935; rs35917562; rs2577164; rs5781163; rs12068478; rs7545874; rs6669531; rs35942761; rs36078678; rs1768674; rs12126592; rs12754826; rs6677609; rs2647423; rs35420771; rs12098052; rs34415535; rs2291837; rs10582505; rs2647434; rs2577157; rs12057468; rs10551734; rs2789806; rs12091960; rs35440326; rs33962064; rs34070653; rs2789800; rs3835619; rs34052861; rs35525846; rs34510927; rs35952109; rs3830400; rs1614719; rs10698600; rs7544184; rs35962858; rs953756; rs12031429; rs6670629; rs12080610; rs28609698; rs3830399; rs33914465; rs2647449; rs34314894; rs12090303; rs10570178; rs36181278; rs35341641; rs12736674; rs7414048; rs2647450; rs10569658; rs2789819; rs35995726; rs35247222; rs7548301; rs12084196; rs12059479; rs34224725; rs35329556; rs2647437; rs3767673; rs2647475; rs35539406; rs11414713; rs11340220; rs11323724; rs10547980; rs11118482; rs3767667; rs12060231; rs35015102; rs35656997; rs2647452; rs12145391; rs35659781; rs11808639; rs12097441; rs12141971; rs10157133; rs7525311; rs10612871; rs12071984; rs35469644; rs34084629; rs2789808; rs34084372; rs12238988; rs12059527; rs12754990; rs2647427; rs34218503; rs9786983; rs10645019; rs12747650; rs2789807; rs11284910; rs35194885; rs34320023; rs12062082; rs11325774; rs10697205; rs10638364; rs2789805; rs10697206; rs35018508; rs10465680; rs35938749; rs10554810; rs5781161; rs12090804; rs11118478; rs6680671; rs34316201; rs35787330; rs2795315; rs41304103; rs10656420; rs34626963; rs1614384; rs12071410; rs12059273; rs11291617; rs35145633; rs2647451; rs2647456; rs34170326; rs12040930; rs2647422; rs36089275; rs34459588; rs35449773; rs35391458; rs12045445; rs7539406; rs1542840; rs34090474; rs1614585; rs41274788; rs2011624; rs12095669; rs34544630; rs6702241; rs2647421; rs28612895; rs7524382; rs10442691; rs12081205; rs34917248; rs2133196; rs10551735; rs34309222; rs35204038; rs3835618; rs6667964; rs35446521; rs35241194; rs41304101; rs17007032; rs11278281; rs2647426; rs10595099; rs11382775; rs12049352; rs35440314; rs10570179; rs12058150; rs3055587; rs34026037; rs34537346; rs34343274; rs12076227; rs12046562; rs34094913; rs3835617; rs34000580; rs34321649; rs35060859; rs35108914; rs2647455; rs1909199; rs3916109; rs36065087; rs28570471; rs12072662; rs11286771; rs11118481; rs2789803; rs2577162; rs11317813; rs5781164; rs35421250; rs10157645; rs5781160; rs35984976; rs11355174; rs35879695; rs35533895; rs10611128; rs11590370; rs10779390; rs11118476; rs12734813; rs2789784; rs4846608; rs6663868; rs6663947; rs7516830; rs7549576

# Metabolic_Enzyme_2_General_References:
1988429; 3290852; 1756734; 1556743; 11123902

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5448

# Metabolic_Enzyme_3_Name:
Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1

# Metabolic_Enzyme_3_Synonyms:
Hexosephosphate aminotransferase 1; D-fructose-6- phosphate amidotransferase 1; GFAT 1; GFAT1

# Metabolic_Enzyme_3_Gene_Name:
GFPT1

# Metabolic_Enzyme_3_Protein_Sequence:
>Glucosaminefructose6phosphate aminotransferase isomerizing 1
MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWEANACKIQLI
KKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIV
IHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQ
LEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTRW
GSQGERGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVA
AVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRG
RVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELAS
DFLDRNTPVFRDDVCFFLSQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGV
HINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLS
MDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLAL
VDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVD
CLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE

# Metabolic_Enzyme_3_Number_of_Residues:
699

# Metabolic_Enzyme_3_Molecular_Weight:
78808

# Metabolic_Enzyme_3_Theoretical_pI:
7.11

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
Function:  glutamine-fructose-6-phosphate transaminase (isomerizing) activity
 ||
>>>
Process:  carbohydrate metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  carbohydrate biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_3_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_3_Specific_Function:
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins

# Metabolic_Enzyme_3_Pathway:
map00251  Glutamate metabolism;
 map00530  Aminosugars metabolism

# Metabolic_Enzyme_3_Reaction:
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00310:GATase_2;
PF01380:SIS

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.6.1.16

# Metabolic_Enzyme_3_GenBank_ID_Protein:
183082

# Metabolic_Enzyme_3_SwissProt_ID:
GFPT1_HUMAN (Q06210)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
GFPT1

# Metabolic_Enzyme_3_Geneatlas_id:
GFPT1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:4241

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>2046 bp
ATGTGTGGTATATTTGCTTACTTAAACTACCATGTTCCTCGAACGAGACGAGAAATCCTG
GAGACCCTAATCAAAGGCCTTCAGAGACTGGAGTACAGAGGATATGATTCTGCTGGTGTG
GGATTTGATGGAGGCAATGATAAAGATTGGGAAGCCAATGCCTGCAAAACCCAGCTTATT
AAGAAGAAAGGAAAAGTTAAGGCACTGGATGAAGAAGTTCACAAGCAACAAGATATGGAT
TTGGATATAGAATTTGATGTACACCTTGGAATAGCTCATACCCGTTGGGCAACACATGGA
GAACCCAGTCCTGTCAATAGCCACCCCCAGCGCTCTGATAAAAATAATGAATTTATCGTT
ATTCACAATGGAATCATCACCAACTACAAAGACTTGAAAAAGTTTTTGGAAAGCAAAGGC
TATGACTTCGAATCTGAAACAGACACAGAGACAATTGCCAAGCTCGTTAAGTATATGTAT
GACAATCGGGAAAGTCAAGATACCAGCTTTACTACCTTGGTGGAGAGAGTTATCCAACAA
TTGGAAGGTGCTTTTGCACTTGTGTTTAAAAGTGTTCATTTTCCCGGGCAAGCAGTTGGC
ACAAGGCGAGGTAGCCCTCTGTTGATTGGTGTACGGAGTGAACATAAACTTTCTACTGAT
CACATTCCTATACTCTACAGAACAGGCAAAGACAAGAAAGGAAGCTGCAATCTCTCTCGT
GTGGACAGCACAACCTGCCTTTTCCCGGTGGAAGAAAAAGCAGTGGAGTATTACTTTGCT
TCTGATGCAAGTGCTGTCATAGAACACACCAATCGCGTCATCTTTCTGGAAGATGATGAT
GTTGCAGCAGTAGTGGATGGACGTCTTTCTATCCATCGAATTAAACGAACTGCAGGAGAT
CACCCCGGACGAGCTGTGCAAACACTCCAGATGGAACTCCAGCAGATCATGAAGGGCAAC
TTCAGTTCATTTATGCAGAAGGAAATATTTGAGCAGCCAGAGTCTGTCGTGAACACAATG
AGAGGAAGAGTCAACTTTGATGACTATACTGTGAATTTGGGTGGTTTGAAGGATCACATA
AAGGAGATCCAGAGATGCCGGCGTTTGATTCTTATTGCTTGTGGAACAAGTTACCATGCT
GGTGTAGCAACACGTCAAGTTCTTGAGGAGCTGACTGAGTTGCCTGTGATGGTGGAACTA
GCAAGTGACTTCCTGGACAGAAACACACCAGTCTTTCGAGATGATGTTTGCTTTTTCCTT
AGTCAATCAGGTGAGACAGCAGATACTTTGATGGGTCTTCGTTACTGTAAGGAGAGAGGA
GCTTTAACTGTGGGGATCACAAACACAGTTGGCAGTTCCATATCACGGGAGACAGATTGT
GGAGTTCATATTAATGCTGGTCCTGAGATTGGTGTGGCCAGTACAAAGGCTTATACCAGC
CAGTTTGTATCCCTTGTGATGTTTGCCCTTATGATGTGTGATGATCGGATCTCCATGCAA
GAAAGACGCAAAGAGATCATGCTTGGATTGAAACGGCTGCCTGATTTGATTAAGGAAGTA
CTGAGCATGGATGACGAAATTCAGAAACTAGCAACAGAACTTTATCATCAGAAGTCAGTT
CTGATAATGGGACGAGGCTATCATTATGCTACTTGTCTTGAAGGGGCACTGAAAATCAAA
GAAATTACTTATATGCACTCTGAAGGCATCCTTGCTGGTGAATTGAAACATGGCCCTCTG
GCTTTGGTGGATAAATTGATGCCTGTGATCATGATCATCATGAGAGATCACACTTATGCC
AAGTGTCAGAATGCTCTTCAGCAAGTGGTTGCTCGGCAGGGGCGGCCTGTGGTAATTTGT
GATAAGGAGGATACTGAGACCATTAAGAACACAAAAAGAACGATCAAGGTGCCCCACTCA
GTGGACTGCTTGCAGGGCATTCTCAGCGTGATCCCTTTACAGTTGCTGGCTTTCCACCTT
GCTGTGCTGAGAGGCTATGATGTTGATTTCCCACGGAATCTTGCCAAATCTGTGACTGTA
GAGTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M90516

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_3_Locus:
2p13

# Metabolic_Enzyme_3_SNPs:
rs17312042; rs2667; rs4546050; rs6546505; rs4447647; rs4549136; rs6546503; rs4369907; rs5013338; rs4340572; rs6546509; rs6722492; rs4416261; rs7571096; rs6546510; rs4078089; rs4625963; rs6747247; rs6724567; rs6728752; rs4452195; rs7578692; rs4524165; rs6757629; rs4592895; rs4428054; rs6713705; rs13419122; rs6742733; rs7579556; rs11887344; rs6705452; rs12713677; rs6720415; rs4410327; rs6738707; rs10164798; rs10195277; rs7424361; rs4473430; rs6755522; rs6705460; rs12473304; rs6546504; rs7579871; rs10167510; rs6753031; rs10200376; rs7589430; rs6725340; rs6546508; rs6713769; rs6747567; rs4479469; rs11883756; rs10170655; rs7607351; rs7578988; rs13394686; rs6728202; rs13422656; rs7596845; rs12613765; rs12466648; rs6724874; rs13429805; rs10172351; rs7592803; rs7596544; rs6747389; rs4410328; rs7558839; rs4353693; rs6727392; rs9808023; rs6546511; rs10198171; rs10198150; rs35703185; rs17854372; rs1803646; rs6729690; rs13000879; rs34022306; rs35228072; rs13406505; rs7340311; rs11486522; rs13394893; rs35072608; rs34318105; rs9678510; rs34621378; rs10191300; rs7597098; rs5831970; rs10180609; rs11422876; rs7589970; rs34846508; rs9808097; rs35846165; rs10560036; rs34865102; rs34139905; rs34723803; rs7599338; rs34152035; rs13016371; rs35042449; rs35969126; rs13410401; rs34496195; rs34090357; rs11689204; rs13389936; rs35577873; rs13424862; rs4402813; rs10602884; rs13003042; rs13026217; rs34686385; rs13026795; rs7595415; rs6724399; rs11439496; rs6546507; rs35454289; rs11420444; rs11296709; rs13026027; rs34170709; rs35630408; rs13026609; rs13385161; rs35356748; rs13393162; rs7340310; rs35112325; rs34121282; rs12474957; rs12997521; rs13002847; rs10689762; rs11360015; rs11489048; rs35106317; rs11464823; rs28678591; rs11458758; rs34325453; rs13431730; rs6759162; rs10700322; rs13019789; rs10175215; rs11363421; rs34091929; rs35658587; rs13392380; rs10714224; rs35392088; rs13408397; rs5831971; rs35105753; rs13430064; rs6721745; rs35636082; rs10203225; rs13026233; rs35631369; rs13026810; rs10203394; rs34754512; rs34527712; rs34022172; rs35777075; rs13411452; rs11889454; rs4302256; rs10715095; rs10674804; rs35619705; rs10196679; rs11883798; rs10172902; rs11407687; rs34806849; rs35361967; rs34509988; rs13388542; rs34477438; rs4402814; rs35366403; rs13385290; rs17552724; rs10185336; rs3182038; rs13385291; rs7568674; rs36057221; rs34799398; rs10170036; rs12615384; rs13751; rs35380455; rs4493312; rs4535086; rs5017686; rs7559627; rs7586596

# Metabolic_Enzyme_3_General_References:
1460020; 11679416

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
6004

# Metabolic_Enzyme_4_Name:
Gamma-glutamyltransferase 5 precursor

# Metabolic_Enzyme_4_Synonyms:
Gamma- glutamyltranspeptidase 5; Gamma-glutamyltransferase-like activity 1; GGT-rel[Contains: Gamma-glutamyltransferase 5 heavy chain; Gamma- glutamyltransferase 5 light chain]

# Metabolic_Enzyme_4_Gene_Name:
GGTLA1

# Metabolic_Enzyme_4_Protein_Sequence:
>Gammaglutamyltransferase 5 precursor
MARGYGATVSLVLLGLGLALAVIVLAVVLSRHQAPCGPQAFAHAAVAADSKVCSDIGRAI
LQQQGSPVDA
TIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPASHAP
SLLDQCAQALPLGTGAQWIGV
PGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAP
VLSRFLHNSILRPSLQASTLRQLFFNGTEPLR
PQDPLPWPALATTLETVATEGVEVFYT
GRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTL
YSPPPPAGGAILSFIL
NVLRGFNFSTESMARPEGRVNVYHHLVETLKFAKGQRWRLGDPRSHPKLQNASR
DLLGE
TLAQLIRQQIDGRGDHQLSHYSLAEAWGHGTGTSHVSVLGEDGSAVAATSTINTPFGAMV
YSPRT
GIILNNELLDLCERCPRGSGTTPSPVSGDRVGGAPGRCWPPVPGERSPSSMVPS
ILINKAQGSKLVIGGA
GGELIISAVAQAIMSKLWLGFDLRAAIAAPILHVNSKGCVEYE
PNFSQEVQRGLQDRGQNQTQRPFFLNV
VQAVSQEGACVYAVSDLRKSGEAAGY

# Metabolic_Enzyme_4_Number_of_Residues:
586

# Metabolic_Enzyme_4_Molecular_Weight:
62262

# Metabolic_Enzyme_4_Theoretical_pI:
7.59

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring amino-acyl groups
Function:  gamma-glutamyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4)

# Metabolic_Enzyme_4_Pathway:
map00430  Taurine and hypotaurine metabolism;
 map00450  Selenoamino acid metabolism;
 map00460  Cyanoamino acid metabolism;
 map00480  Glutathione metabolism;
 map00590  Prostaglandin and leukotriene metabolism

# Metabolic_Enzyme_4_Reaction:
(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01019:G_glu_transpept

# Metabolic_Enzyme_4_Signals:
1-26

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.3.2.2

# Metabolic_Enzyme_4_GenBank_ID_Protein:
183142

# Metabolic_Enzyme_4_SwissProt_ID:
GGT5_HUMAN (P36269)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
GGTLA1

# Metabolic_Enzyme_4_Geneatlas_id:
GGTLA1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:4260

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_4_Gene_Sequence:
>1761 bp

ATGGCCCGGGGCTACGGGGCCACGGTCAGCCTAGTCCTGCTGGGTCTGGGGCTGGCGCT
GGCTGTCATTG
TGCTGGCTGTGGTCCTCTCTCGACACCAGGCCCCATGTGGCCCCCAGG
CCTTTGCCCACGCTGCTGTTGC
CGCCGACTCCAAGGTCTGCTCGGATATTGGACGAGCC
ATCCTCCAGCAGCAGGGCTCACCCGTGGATGCC
ACCATCGCGGCTCTGGTCTGCACCAG
CGTCGTCAACCCTCAGAGCATGGGCCTGGGCGGAGGGGTCATCT
TCACCATCTACAATG
TGACAACAGGGAAGGTGGAGGTCATCAATGCCCGGGAGACGGTGCCGGCCAGCCA
CGCC
CCGAGCCTGCTGGACCAGTGTGCACAGGCTCTGCCACTGGGCACAGGGGCCCAGTGGATC
GGGGTG
CCCGGGGAGCTCCGTGGCTATGCCGAGGCCCACCGCCGCCATGGCCGCCTGCC
CTGGGCGCAGCTGTTCC
AGCCCACCATCGCGCTGCTCCGAGGGGGGCATGTGGTGGCCC
CTGTCCTCAGCCGTTTCCTGCACAACAG
CATCCTGCGGCCTTCCTTGCAGGCGTCAACC
CTGCGCCAGCTCTTCTTCAACGGGACAGAACCCCTGAGG
CCTCAGGACCCACTCCCATG
GCCTGCACTGGCCACCACCCTGGAGACCGTGGCCACAGAGGGCGTGGAGG
TCTTCTACA
CGGGGAGGCTGGGCCAGATGCTGGTGGAGGACATTGCCAAGGAAGGGAGCCAGCTGACGC
T
GCAGGACCTGGCCAAGTTCCAGCCCGAGGTGGTGGATGCCCTGGAGGTGCCCCTGGGG
GACTATACCCTG
TACTCACCACCGCCGCCTGCAGGGGGTGCCATTCTCAGCTTTATCCT
CAACGTGCTAAGAGGGTTCAACT
TCTCAACAGAGTCTATGGCCAGGCCTGAAGGGAGGG
TGAACGTGTACCACCACCTTGTAGAGACGCTCAA
GTTTGCCAGGGGGCAGAGGTGGAGG
CTGGGGGACCCTCGAAGCCACCCGAAGCTCCAGAATGCCTCCCGG
GACCTGCTGGGGGA
GACCCTGGCCCAGCTCATCCGCCAACAGATCGATGGCCGGGGGGACCACCAGCTCA
GCC
ACTACAGCTTGGCCGAGGCCTGGGGCCACGGGACAGGCACGTCCCATGTGTCTGTGCTGG
GGGAGGA
TGGCAGCGCCGTGGCTGCCACCAGCACCATCAACACACCCTTTGGAGCGATG
GTGTATTCACCACGGACA
GGCATCATCCTCAACAACGAGCTCCTGGACTTATGCGAGCG
ATGCCCCTGGGGTTCCGGCACCACCCCCT
CACCTGTGAGTGGAGACAGGGTGGGTGGAG
CTCCCGGAAGGTGCTGGCCCCCAGTTCCAGGCGAGCGTTC
CCCATCCTCCATGGTGCCC
TCCATCTTGATCAACAAAGCCCAGGGGTCGAAGCTAGTGATTGGCGGGGCT
GGCGGGGA
GCTCATCATCTCTGCTGTGGCCCAGGCCATCATGAGCAAGCTGTGGCTTGGCTTTGACCT
GA
GAGCGGCCATTGCAGCCCCCATCCTGCATGTCAACAGCAAGGGCTGTGTGGAGTACG
AGCCCAACTTCAG
CCAGGAGGTGCAGAGGGGACTCCAAGACCGTGGCCAGAACCAGACC
CAGAGGCCCTTCTTCCTGAACGTG
GTCCAGGCTGTGTCCCAGGAGGGGGCCTGTGTGTA
CGCCGTCTCGGACCTGAGGAAGAGTGGGGAGGCCG
CAGGCTACTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M64099

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_4_Locus:
22q11.23

# Metabolic_Enzyme_4_SNPs:
rs7288201; rs2275984; rs762276; rs4443101; rs8140505; rs2267073; rs8135709; rs2267074; rs5996675; rs5996676; rs8142702; rs4822473; rs8140559; rs5751820; rs2275985; rs5751822; rs5760273; rs9612567; rs7286769; rs12627971; rs8141279; rs2330738; rs9608253; rs5760270; rs9608254; rs6004109; rs6004104; rs8135864; rs7288670; rs7286276; rs9608250; rs5760271; rs2877206; rs5751821; rs518219; rs9612575; rs2275983; rs7286275; rs6004103; rs9608256; rs915597; rs9608255; rs738810; rs2078191; rs11090315; rs13053599; rs12166260; rs11913528; rs5751819; rs5760274; rs6004105; rs8142028; rs34787869; rs3171733; rs28470453; rs35519802; rs4049960; rs8141921; rs2186375; rs11446984; rs11912938; rs35151649; rs9608251; rs34162764; rs9612568; rs34456415; rs36080744; rs9608261; rs507572; rs12158478; rs8141917; rs7288678; rs9612571; rs12169644; rs4049956; rs9624432; rs8140966; rs8140009; rs12170724; rs35658121; rs12165595; rs13054993; rs34139406; rs36078496; rs5760272; rs28558344; rs2196265; rs7286843; rs34408756; rs9612569; rs9608257; rs6004107; rs8140350; rs7289730; rs28765434; rs28581334; rs34254169; rs915596; rs9608263; rs9608258; rs35424805; rs9624434; rs9624435; rs4049959; rs8142438; rs5760267; rs34213657; rs8137278; rs34286685; rs35687403; rs507543; rs28433519; rs9612570; rs9608252; rs6004108; rs5760268; rs34690574; rs35456290; rs35720801; rs34544519; rs507578; rs35482725; rs8141879; rs13056182; rs35048159; rs35924097; rs34183480; rs35060391; rs4049958; rs35676668; rs9612572; rs5760269; rs35673322; rs8137410; rs9608260; rs7285631; rs13054426; rs2154608; rs35357003; rs34686376; rs7291369; rs2186373; rs9680720; rs35387722; rs9608262; rs10428035; rs12158941; rs13054853; rs2186374; rs3966270; rs11913894; rs7290701; rs10427555; rs34505104; rs7291063; rs8142646; rs12169182; rs4049957; rs12160538; rs34593708; rs8136200; rs13054966; rs9608259; rs507542; rs4049961; rs5760266; rs4408818; rs28562380; rs9624430; rs8137281; rs35334731; rs204713; rs12159878; rs5760265; rs7289030; rs34949320; rs34303680; rs34756406; rs28503851; rs13055027; rs13057276; rs12166267; rs9608249; rs35351787; rs34288539; rs28447258; rs28480057; rs28635067; rs34513858; rs35229275; rs583199; rs5996674; rs6004094; rs6004099; rs743359; rs743360; rs9612564

# Metabolic_Enzyme_4_General_References:
1676842; 10591208

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5959

# Metabolic_Enzyme_5_Name:
Formimidoyltransferase-cyclodeaminase

# Metabolic_Enzyme_5_Synonyms:
Formiminotransferase- cyclodeaminase; FTCD; LCHC1[Includes: Glutamate formimidoyltransferase; Glutamate formiminotransferase; Glutamate formyltransferase; Formimidoyltetrahydrofolate cyclodeaminase; Formiminotetrahydrofolate cyclodeaminase]

# Metabolic_Enzyme_5_Gene_Name:
FTCD

# Metabolic_Enzyme_5_Protein_Sequence:
>Formimidoyltransferasecyclodeaminase
MSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVE
GALNAARVASRLIDMSRHQGEHPRMGALDVCPFIPVRGVSVDECVLCAQAFGQRLAEELD
VPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGARK
FLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLD
FEVTALHTVYEETCREAQELSLPVVGSQLVGLVPLKALLDAAAFYCEKENLFILEEEQRI
RLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGSVA
AAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYL
EAMRLPKNTPEEKDRRTAALQEGLRRAVSVPLTLAETVASLWPALQELARCGNLACRSDL
QVAAKALEMGVFGAYFNVLINLRDITDEAFKDQIHHRVSSLLQEAKTQAALVLDCLETRQ
E

# Metabolic_Enzyme_5_Number_of_Residues:
541

# Metabolic_Enzyme_5_Molecular_Weight:
58927

# Metabolic_Enzyme_5_Theoretical_pI:
5.45

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  binding
Function:  vitamin binding
Function:  folic acid binding
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool

# Metabolic_Enzyme_5_Pathway:
map00670  One carbon pool by folate

# Metabolic_Enzyme_5_Reaction:
5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF02971:FTCD;
PF04961:FTCD_C;
PF07837:FTCD_N

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.1.2.5;EC 4.3.1.4

# Metabolic_Enzyme_5_GenBank_ID_Protein:
6537208

# Metabolic_Enzyme_5_SwissProt_ID:
FTCD_HUMAN (O95954)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
FTCD

# Metabolic_Enzyme_5_Geneatlas_id:
FTCD

# Metabolic_Enzyme_5_hgnc_id:
HGNC:3974

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm. Golgi apparatus (By similarity)

# Metabolic_Enzyme_5_Gene_Sequence:
>1626 bp
ATGTCCCAGCTGGTGGAATGCGTCCCCAACTTTTCGGAGGGGAAGAACCAGGAGGTGATC
GACGCCATCTCTGGAGCCATCACACAGACCCCGGGCTGCGTGCTGCTGGATGTGGACGCA
GGCCCTTCCACCAACCGCACCGTGTACACCTTCGTGGGGCCGCCGGAGTGCGTGGTGGAG
GGGGCCCTCAACGCTGCCCGGGTAGCTTCCCGACTTATCGACATGAGCAGGCACCAAGGA
GAGCACCCCCGCATGGGGGCCCTAGACGTCTGCCCCTTCATCCCCGTGAGGGGCGTCAGC
GTGGATGAGTGTGTGCTCTGCGCCCAGGCCTTTGGCCAGAGGCTGGCAGAGGAGCTGGAC
GTGCCAGTTTACCTGTACGGCGAGGCAGCCAGGATGGACAGTCGCCGGACCCTGCCGGCC
ATCCGGGCCGGGGAGTACGAGGCCCTCCCTAAGAAGCTCCAGCAGGCCGACTGGGCGCCC
GACTTTGGTCCCAGCTCCTTTGTCCCCAGTTGGGGGGCCACGGCCACGGGGGCGAGGAAG
TTCCTCATTGCTTTTAACATCAACCTGCTCGGCACAAAGGAGCAAGCCCACCGCATCGCG
CTCAACCTGCGGGAGCAGGGCCGCGGGAAGGACCAGCCAGGACGTCTGAAGAAAGTTCAG
GGCATTGGCTGGTACCTGGATGAGAAGAACCTGGCTCAGGTGTCCACCAATCTTCTGGAC
TTTGAGGTCACGGCACTGCACACGGTCTACGAGGAGACCTGCCGAGAAGCACAGGAGCTG
AGCCTCCCAGTGGTGGGCTCACAGCTGGTGGGCCTGGTGCCCCTGAAGGCTCTGCTGGAT
GCGGCCGCCTTCTACTGCGAGAAGGAGAACCTCTTCATCCTGGAGGAGGAGCAGCGGATC
AGGCTGGTGGTGAGCCGGCTGGGCCTGGACTCCCTGTGCCCCTTCAGCCCTAAGGAGCGG
ATCATCGAGTACCTGGTCCCTGAGCGCGGGCCTGAGCGAGGCCTGGGCAGCAAGTCCCTG
CGCGCCTTCGTGGGGGAGGTGGGTGCCCGCTCTGCGGCCCCCGGGGGCGGCTCGGTGGCG
GCGGCCGCTGCGGCCATGGGTGCGGCGCTGGGCTCCATGGTGGGCCTCATGACCTACGGG
CGGCGCCAATTCCAGTCCCTGGACACGACGATGCGGCGCCTGATCCCGCCCTTCCGCGAG
GCTTCGGCCAAGCTAACCACGCTGGTGGATGCCGACGCCGAGGCCTTCACCGCCTACCTG
GAAGCAATGAGGCTCCCCAAGAACACACCTGAGGAAAAGGACAGGCGCACGGCGGCCCTA
CAGGAGGGTCTGAGGCGGGCAGTCTCTGTGCCGCTGACGCTGGCGGAGACGGTGGCCTCG
CTGTGGCCGGCGCTGCAGGAACTGGCCCGGTGTGGGAACCTGGCCTGCCGGTCAGACCTC
CAGGTGGCGGCCAAAGCCCTGGAGATGGGCGTGTTTGGCGCATATTTCAACGTGCTCATC
AACCTGAGGGACATCACAGACGAGGCATTTAAGGACCAGATCCACCATCGTGTTTCCAGC
CTCCTGCAGGAAGCCAAGACCCAGGCTGCACTGGTGCTGGACTGCTTGGAGACCCGGCAG
GAGTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AF169017

# Metabolic_Enzyme_5_Chromosome_Location:
Not Available

# Metabolic_Enzyme_5_Locus:
Not Available

# Metabolic_Enzyme_5_SNPs:
rs10432965; rs2277821; rs12774; rs1047209; rs2839127; rs2839126; rs725976; rs2277820; rs7282864; rs9976772; rs2839124; rs1556341; rs1980983; rs9978174; rs7277617; rs11908960; rs2010958; rs7279849; rs9974320; rs17292975; rs2839125; rs4819208; rs17004505; rs8126678; rs11909944; rs17004504; rs8134417; rs16978935; rs4819207; rs11911736; rs9284510; rs1556340; rs16978930; rs9974226; rs3746999; rs17004506; rs11911593; rs16978932; rs4484116; rs1556339; rs11089051; rs4819209; rs914245; rs914246; rs8128111; rs8128270; rs7276274; rs28941768; rs8133955; rs1047179; rs34762382; rs35337947; rs9653792; rs9653793; rs33926654; rs2277819; rs8133080; rs4818824; rs34248722; rs34788232; rs35123061; rs7278881; rs9984474; rs28413731; rs7275864; rs9983829; rs34823397; rs4819206; rs3747000; rs35273895; rs4819205; rs9978647; rs36026689; rs12482309; rs9982796; rs2277818; rs9981364; rs7283985; rs5844255; rs13052919; rs34564917; rs12627256; rs3057182; rs8134628; rs3057172; rs4819204; rs3746998; rs34007993; rs8133524; rs4818825; rs8131374; rs28437812; rs8131105; rs10594439; rs11089050; rs11283939; rs9974540; rs8127720; rs11701284; rs35899631; rs35655527; rs11909099; rs11279411; rs35208133; rs10188; rs1042930; rs1044598; rs11908812; rs11908934; rs11909205; rs11910483; rs12329660; rs12329865; rs12482002; rs12626197; rs12626732; rs12626746; rs13050201; rs13050660; rs14378; rs16978878; rs16978880; rs16978895; rs16978897; rs16978913; rs17272947; rs17292141; rs2236492; rs2839115; rs2839116; rs2839117; rs2839118; rs2839119; rs2839120; rs2839121; rs2839122; rs2839123; rs34433115; rs35139588; rs35548026; rs35887009; rs3746997; rs3747001; rs3747002; rs3747003; rs4819210; rs559; rs6518273; rs6652; rs7280396; rs7280485; rs7281816; rs7282065; rs7717; rs8126854; rs9974913; rs9976171; rs9977394; rs9977572; rs9977766; rs9980548

# Metabolic_Enzyme_5_General_References:
10773664; 10029623; 12815595

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5403

# Metabolic_Enzyme_6_Name:
Dimethylaniline monooxygenase [N-oxide-forming] 3

# Metabolic_Enzyme_6_Synonyms:
Hepatic flavin-containing monooxygenase 3; FMO 3; Dimethylaniline oxidase 3; FMO form 2; FMO II

# Metabolic_Enzyme_6_Gene_Name:
FMO3

# Metabolic_Enzyme_6_Protein_Sequence:
>Dimethylaniline monooxygenase Noxideforming 3
MGKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKFSDHAEEGRASIYKSVFS
NSSKEMMCFPDFPFPDDFPNFMHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKHPDFA
TTGQWDVTTERDGKKESAVFDAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPG
VFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVWDNGYPWDMLLVTRFG
TFLKNNLPTAISDWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVK
PNVKEFTETSAIFEDGTIFEGIDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPL
LEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPSMEDMMNDINEKMEKKRKWF
GKSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQWP
GARNAILTQWDRSLKPMQTRVVGRLQKPCFFFHWLKLFAIPILLIAVFLVLT

# Metabolic_Enzyme_6_Number_of_Residues:
532

# Metabolic_Enzyme_6_Molecular_Weight:
60034

# Metabolic_Enzyme_6_Theoretical_pI:
7.87

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  disulfide oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen
Function:  dimethylaniline monooxygenase (N-oxide-forming) activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  cell
Component:  cell fraction
Component:  membrane fraction
Component:  vesicular fraction
Component:  microsome

# Metabolic_Enzyme_6_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Acts on TMA to produce TMA-N-oxide

# Metabolic_Enzyme_6_Pathway:
Not Available

# Metabolic_Enzyme_6_Reaction:
N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00743:FMO-like

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
509-531

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.14.13.8

# Metabolic_Enzyme_6_GenBank_ID_Protein:
188631

# Metabolic_Enzyme_6_SwissProt_ID:
FMO3_HUMAN (P31513)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
FMO3

# Metabolic_Enzyme_6_Geneatlas_id:
FMO3

# Metabolic_Enzyme_6_hgnc_id:
HGNC:3771

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Microsome

# Metabolic_Enzyme_6_Gene_Sequence:
>1602 bp
ATGGGGAAGAAAGTGGCCATCATTGGAGCTGGTGTGAGTGGCTTGGCCTCCATCAGGAGC
TGTCTGGAAGAGGGGCTGGAGCCCACCTGCTTTGAGAAGAGCAATGACATTGGGGGCCTG
TGGAAATTTTCAGACCATGCAGAGGAGGGCAGGGCTAGCATTTACAAATCAGTCTTTTCC
AACTCTTCCAAAGAGATGATGTGTTTCCCAGACTTCCCATTTCCCGATGACTTCCCCAAC
TTTATGCACAACAGCAAGATCCAGGAATATATCATTGCATTTGCCAAAGAAAAGAACCTC
CTGAAGTACATACAATTTAAGACATTTGTATCCAGTGTAAATAAACATCCTGATTTTGCA
ACTACTGGCCAGTGGGATGTTACCACTGAAAGGGATGGTAAAAAAGAATCGGCTGTCTTT
GATGCTGTAATGGTTTGTTCCGGACATCATGTGTATCCCAACCTACCAAAAAAGTCCTTT
CCAGGACTAAACCACTTTAAAGGCAAATGCTTCCACAGCAGGGACTATAAAGAACCAGGT
GTATTCAATGGAAAGCGTGTCCTGGTGGTTGGCCTGGGGAATTCGGGCTGTGATATTGCC
ACAGAACTCAGCCGCACAGCAGAACAGGTCATGATCAGTTCCAGAAGTGGCTCCTGGGTG
ATGAGCCGGGTCTGGGACAATGGTTATCCTTGGGACATGCTGCTCGTCACTCGATTTGGA
ACCTTCCTCAAGAACAATTTACCGACAGCCATCTCTGACTGGTTGTACGTGAAGCAGATG
AATGCAAGATTCAAGCATGAAAACTATGGCTTGATGCCTTTAAATGGAGTCCTGAGGAAA
GAGCCTGTATTTAACGATGAGCTCCCAGCAAGCATTCTGTGTGGCATTGTGACCGTAAAG
CCTAACGTGAAGGAATTCACAGAGACCTCGGCCATTTTTGAGGATGGGACCATATTTGAG
GGCATTGACTGTGTAATCTTTGCAACAGGGTATAGTTTTGCCTACCCCTTCCTTGATGAG
TCTATCATCAAAAGCAGAAACAATGAGATCATTTTATTTAAAGGAGTATTTCCTCCTCTA
CTTGAGAAGTCAACCATAGCAGTATTGGGCTTTGTCCAGTCCCTTGGGGCTGCCATTCCC
ACAGTTGACCTCCAGTCCCGCTGGGCAGCACAAGTAATAAAGGGAACTTGTACTTTGGGC
CCTTTCTATGGGAAGACATTGATGAATGATATTATTGAGAAAATGGAGAAAAAGCGGGCA
AATGGGTTTGGCAAAAGCGAGACCATACAGACAGATTACATTGTTTATATGGATGAACTC
TCCTCCTTCATTGGGGCAACCAACATCCCAATGCTGTTCCTCACAGGTCCCAAATTGGCC
ATGGAGTTATTTGGGCCCTGTAGTCCCTACCAGTTTAGGCTGGTGGGCCCAGGCAGCTGG
CCAGGAGCCAGAAATGCCATACTGACCCAGTGGGACCGGTCGTTGAAACCCATGCAGACA
CGAGTGGTCGGGAGACTTCAGAAGCCTTGCTTCTTTTTCCATTGGCTGAAGCTCTTTGCA
ATTCCTATTCTGTTAATCGCTGTTTTCCTTGTGTTGACCTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M83772

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_6_Locus:
1q23-q25

# Metabolic_Enzyme_6_SNPs:
rs2266782; rs1736557; rs2266780; rs2066532; rs2066530; rs12072582; rs909530; rs1800822; rs28363595; rs7880493; rs1736561; rs11578281; rs28363524; rs28363522; rs7060320; rs7880204; rs7881612; rs28363523; rs1920149; rs2236873; rs1736559; rs1736556; rs2064075; rs2066534; rs909531; rs2075992; rs7061710; rs10797894; rs7062331; rs1736566; rs6608462; rs909529; rs1080197; rs2236872; rs2281002; rs2066537; rs909532; rs10797877; rs12405599; rs2235192; rs6608463; rs10911192; rs7051320; rs2064076; rs12403297; rs16864050; rs2066529; rs16864066; rs17564980; rs10797878; rs10911238; rs2064074; rs16864042; rs12406572; rs16828308; rs1072255; rs12076145; rs4140653; rs3832023; rs10911320; rs28745588; rs28363552; rs2204791; rs28363530; rs28363589; rs2066528; rs28745584; rs28363570; rs2205725; rs28363593; rs28363539; rs28363564; rs28363536; rs28363557; rs28363537; rs28363543; rs12085248; rs28363562; rs28363528; rs28363544; rs28363527; rs28745580; rs1983550; rs2204790; rs28363535; rs28363591; rs12404455; rs28363560; rs28363551; rs1795239; rs28363583; rs28363533; rs28745585; rs28363571; rs28363553; rs12059956; rs28363541; rs28363578; rs28745589; rs28745592; rs7886526; rs28745579; rs28363563; rs28363558; rs28363588; rs12072717; rs28745582; rs1920137; rs28745581; rs28363545; rs28363575; rs28745593; rs28363542; rs28363550; rs28363540; rs28363526; rs28363584; rs28745591; rs28745586; rs12073562; rs28363590; rs28363554; rs1736555; rs16864006; rs7052352; rs1736560; rs16864007; rs12404183; rs1736554; rs1736558; rs3754487; rs12404218; rs17564210; rs3754489; rs28363513; rs12070707; rs28363597; rs28363515; rs12066527; rs28363596; rs3754491; rs28363549; rs28363581; rs1050906; rs2066536; rs28363546; rs1050902; rs35525949; rs28363521; rs10600742; rs36034922; rs10636613; rs33958279; rs10594148; rs11383160; rs41272509; rs28363520; rs35849478; rs12732215; rs12074448; rs28363566; rs28363547; rs28363559; rs28363532; rs2204793; rs28363569; rs28745590; rs28363579; rs28363580; rs11578651; rs28363577; rs12072547; rs28363586; rs11320098; rs28363572; rs7471289; rs28363585; rs35194229; rs35650903; rs34063190; rs34947289; rs28363555; rs1795248; rs11579293; rs35810404; rs28363525; rs28363582; rs28817873; rs28363576; rs34247334; rs28745578; rs11317520; rs2066531; rs36106873; rs28810082; rs12074485; rs28363567; rs28363531; rs28363538; rs28363574; rs28363587; rs12078163; rs28817425; rs28363565; rs5778693; rs28745583; rs28809513; rs28363592; rs28363529; rs35625940; rs28363561; rs28363594; rs35802574; rs35463008; rs28363534; rs28363568; rs28363556; rs11580161; rs7473127; rs34143632; rs3980650; rs28363573; rs28745587; rs35892452; rs28866833; rs28363516; rs11385180; rs28363514; rs35949891; rs28363518; rs34913672; rs28363517; rs28363519; rs7880894; rs11449828; rs10910879; rs10911641; rs10911664; rs10911694; rs11809504; rs12086786; rs12089338; rs12118296; rs12402295; rs12402693; rs16863987; rs16863989; rs17350502; rs1795240; rs4607926; rs6608459; rs6608461; rs7060028; rs7060055; rs7062329; rs742057; rs742058; rs7474070; rs7474265; rs9970392; rs9970495

# Metabolic_Enzyme_6_General_References:
1542660; 8654418; 9417913; 9536088; 10338091; 10479479; 12527699

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5948

# Metabolic_Enzyme_7_Name:
Glutaminase liver isoform, mitochondrial precursor

# Metabolic_Enzyme_7_Synonyms:
GLS; L-glutamine amidohydrolase; L-glutaminase

# Metabolic_Enzyme_7_Gene_Name:
GLS2

# Metabolic_Enzyme_7_Protein_Sequence:
>Glutaminase liver isoform, mitochondrial precursor
MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQD
HDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQ
ESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVA
AYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHK
FVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAG
NEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESG
SVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGA
ILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGA
EIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIE
ACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLES
MV

# Metabolic_Enzyme_7_Number_of_Residues:
602

# Metabolic_Enzyme_7_Molecular_Weight:
66324

# Metabolic_Enzyme_7_Theoretical_pI:
7.32

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Function:  glutaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Plays an important role in the regulation of glutamine catabolism

# Metabolic_Enzyme_7_Pathway:
map00251  Glutamate metabolism;
 map00471  D-Glutamine and D-glutamate metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_7_Reaction:
L-glutamine + H2O = L-glutamate + NH3

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00023:Ank;
PF04960:Glutaminase

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.5.1.2

# Metabolic_Enzyme_7_GenBank_ID_Protein:
6650606

# Metabolic_Enzyme_7_SwissProt_ID:
GLSL_HUMAN (Q9UI32)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
GLS2

# Metabolic_Enzyme_7_Geneatlas_id:
GLS2

# Metabolic_Enzyme_7_hgnc_id:
HGNC:29570

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_7_Gene_Sequence:
>1809 bp
ATGCGCTCCATGAAGGCTCTGCAGAAGGCCCTGAGCCGGGCTGGCAGTCACTGCGGGCGA
GGAGGCTGGGGTCACCCGAGCCGGAGCCCCCTCCTTGGCGGGGGCGTCCGGCACCACCTC
AGTGAGGCCGCGGCGCAGGGCAGAGAGACGCCACACAGCCACCAGCCGCAGCACCAGGAT
CATGATTCATCAGAAAGTGGCATGCTGTCCCGCCTGGGTGATTTGCTCTTTTACACTATT
GCTGAAGGACAGGAACGAACCCCTATCCACAAGTTCACCACTGCACTAAAGGCCACTGGA
CTGCAGACATCAGATCCTCGGCTCCGAGACTGCATGAGCGAGATGCACCGCGTGGTCCAA
GAGTCCAGTAGTGGTGGCCTCTTGGACCGAGATCTCTTCCGAAAGTGTGTGAGCAGCAGC
ATTGTGCTCCTGACCCAGGCATTCCGAAAGAAGTTTGTCATTCCTGATTTTGAGGAGTTC
ACGGGCCATGTGGATCGCATCTTTGAGGATGTCAAAGAGCTCACTGGAGGCAAAGTGGCA
GCCTACATCCCTCAGCTGGCCAAGTCAAACCCAGACCTGTGGGGTGTCTCCCTGTGCACT
GTGGATGGTCAACGGCACTCTGTGGGCCACACAAAGATCCCCTTCTGCCTGCAGTCCTGT
GTGAAGCCCCTCACCTATGCCATCTCCATAAGCACCCTAGGCACTGACTACGTGCACAAG
TTTGTGGGCAAAGAGCCAAGTGGCCTGCGCTACAACAAGCTCTCCCTCGATGAGGAAGGA
ATCCCCCATAACCCCATGGTCAATGCTGGTGCCATTGTTGTCAGCTCCCTGATCAAGATG
GACTGTAACAAAGCAGAGAAGTTTGATTTTGTGTTGCAGTATCTCAACAAAATGGCTGGG
AATGAATACATGGGTTTCAGCAATGCCACATTCCAGTCAGAGAAGGAAACAGGGGATCGG
AATTATGCCATCGGCTATTATCACGAGGAAAAGAAGTGCTTTCCTAAGGGGGTGGACATG
ATGGCTGCCCTTGATCTCTACTTCCAGCTGTGTTCTGTGGAGGTCACTTGTGAATCAGGC
AGTGTCATGGCAGCCACCCTCGCCAACGGTGGGATTTGCCCCATCACAGGCGAGAGTGTG
CTGAGTGCTGAAGCAGTGCGCAACACCCTCAGCCTCATGCATTCCTGCGGCATGTATGAC
TTCTCTGGCCAGTTTGCCTTCCACGTGGGCCTGCCAGCCAAGTCAGCTGTATCAGGAGCC
ATCCTCCTGGTGGTACCCAATGTCATGGGAATGATGTGCCTGTCACCCCCATTGGACAAG
CTGGGGAACAGCCATAGGGGGACCAGCTTCTGCCAGAAGTTGGTGTCTCTCTTCAATTTC
CACAACTATGACAACCTGAGGCACTGTGCTCGGAAGTTAGACCCACGGCGTGAAGGGGCA
GAAATTCGGAACAAGACTGTGGTCAACCTGTTATTTGCTGCCTATAGTGGCGATGTCTCA
GCTCTTCGAAGGTTTGCCTTGTCAGCCATGGATATGGAACAGAAAGACTATGACTCGCGC
ACAGCTCTGCATGTTGCTGCAGCTGAAGGACACATCGAAGTTGTTAAATTCCTGATCGAG
GCTTGCAAAGTGAATCCTTTTGCCAAGGACAGGTGGGGCAACATTCCCCTGGATGATGCT
GTGCAGTTCAACCATCTGGAGGTGGTCAAACTGCTTCAAGATTACCAGGACTCCTACACA
CTCTCTGAAACTCAGGCTGAGGCAGCAGCTGAGGCCCTGTCCAAAGAGAACTTAGAAAGC
ATGGTATGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AF110330

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_7_Locus:
12q13

# Metabolic_Enzyme_7_SNPs:
rs2657879; rs1043011; rs2638315; rs937115; rs7314242; rs937114; rs6581096; rs2638314; rs11171863; rs12299914; rs2638335; rs4759244; rs7137402; rs12304519; rs7306152; rs2638336; rs7312783; rs2657878; rs11171862; rs3809122; rs2638334; rs11834429; rs3211277; rs34265700; rs2279536; rs12229485; rs5798384; rs11439704; rs35400268; rs10876892; rs35894333; rs11171861; rs11441969; rs7314504; rs35171220; rs34950500; rs12819483; rs35762642; rs2657877; rs34325581; rs11414489; rs35090234; rs34646954; rs12811540; rs11171864; rs34647708; rs12811321; rs12809968; rs35530001; rs10124; rs10876891; rs12313841; rs2638285; rs2638317; rs2638318; rs2638319; rs2657880; rs2657881; rs2657914; rs7298079; rs7302925; rs765817

# Metabolic_Enzyme_7_General_References:
10620514; 11163757

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
6130

# Metabolic_Enzyme_8_Name:
Folylpolyglutamate synthase, mitochondrial precursor

# Metabolic_Enzyme_8_Synonyms:
Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolate synthase; Tetrahydrofolylpolyglutamate synthase

# Metabolic_Enzyme_8_Gene_Name:
FPGS

# Metabolic_Enzyme_8_Protein_Sequence:
>Folylpolyglutamate synthase, mitochondrial precursor
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
HQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
QASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSP
PKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ

# Metabolic_Enzyme_8_Number_of_Residues:
587

# Metabolic_Enzyme_8_Molecular_Weight:
64610

# Metabolic_Enzyme_8_Theoretical_pI:
8.00

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  acid-amino acid ligase activity
Function:  tetrahydrofolylpolyglutamate synthase activity
 ||
>>>
Process:  biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  aromatic compound metabolism
Process:  folic acid and derivative metabolism
Process:  folic acid and derivative biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Conversion of folates to polyglutamate derivatives. This allows tissues to concentrate folate at higher levels than in plasma

# Metabolic_Enzyme_8_Pathway:
map00790  Folate biosynthesis

# Metabolic_Enzyme_8_Reaction:
ATP + tetrahydrofolyl-[Glu]n + L-glutamate = ADP + phosphate + tetrahydrofolyl-[Glu]n+1

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF02875:Mur_ligase_C

# Metabolic_Enzyme_8_Signals:
1-19

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 6.3.2.17

# Metabolic_Enzyme_8_GenBank_ID_Protein:
292029

# Metabolic_Enzyme_8_SwissProt_ID:
FOLC_HUMAN (Q05932)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
FPGS

# Metabolic_Enzyme_8_Geneatlas_id:
FPGS

# Metabolic_Enzyme_8_hgnc_id:
HGNC:3824

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Mitochondrion. Cytoplasm

# Metabolic_Enzyme_8_Gene_Sequence:
>1638 bp
ATGGAGTACCAGGATGCCGTGCGCATGCTCAATACCCTGCAGACCAATGCCGGCTACCTG
GAGCAGGTGAAGCGCCAGCGGGGTGACCCTCAGACACAGTTGGAAGCCATGGAACTGTAC
CTGGCACGGAGTGGGCTGCAGGTGGAGGACTTGGACCGGCTGAACATCATCCACGTCACT
GGGACGAAGGGGAAGGGCTCCACCTGTGCCTTCACGGAATGTATCCTCCGAAGCTATGGC
CTGAAGACGGGATTCTTTAGCTCTCCCCACCTGGTGCAGGTTCGGGAGCGGATCCGCATC
AATGGGCAGCCCATCAGTCCTGAGCTCTTCACCAAGTACTTCTGGCGCCTCTACCACCGG
CTGGAGGAGACCAAGGATGGCAGCTGTGTCTCCATGCCCCCCTACTTCCGCTTCCTGACA
CTCATGGCCTTCCACGTCTTCCTCCAAGAGAAGGTGGACCTGGCAGTGGTGGAGGTGGGC
ATTGGCGGGGCTTATGACTGCACCAACATCATCAGGAAGCCTGTGGTGTGCGGAGTCTCC
TCTCTTGGCATCGACCACACCAGCCTCCTGGGGGATACGGTGGAGAAGATCGCATGGCAG
AAAGGGGGCATCTTTAAGCAAGGTGTCCCTGCCTTCACTGTGCTCCAACCTGAAGGTCCC
CTGGCAGTGCTGAGGGACCGAGCCCAGCAGATCTCATGTCCTCTATACCTGTGTCCGATG
CTGGAGGCCCTCGAGGAAGGGGGGCCGCCGCTGACCCTGGGCCTGGAGGGGGAGCACCAG
CGGTCCAACGCCGCCTTGGCCTTGCAGCTGGCCCACTGCTGGCTGCAGCGGCAGGACCGC
CATGGTGCTGGGGAGCCAAAGGCATCCAGGCCAGGGCTCCTGTGGCAGCTGCCCCTGGCA
CCTGTGTTCCAGCCCACATCCCACATGCGGCTCGGGCTTCGGAACACGGAGTGGCCGGGC
CGGACGCAGGTGCTGCGGCGCGGGCCCCTCACCTGGTACCTGGACGGTGCGCACACCGCC
AGCAGCGCGCAGGCCTGCGTGCGCTGGTTCCGCCAGGCGCTGCAGGGCCGCGAGAGGCCG
AGCGGTGGCCCCGAGGTTCGAGTCTTGCTCTTCAATGCTACCGGGGACCGGGACCCGGCG
GCCCTGCTGAAGCTGCTGCAGCCCTGCCAGTTTGACTATGCCGTCTTCTGCCCTAACCTG
ACAGAGGTGTCATCCACAGGCAACGCAGACCAACAGAACTTCACAGTGACACTGGACCAG
GTCCTGCTCCGCTGCCTGGAACACCAGCAGCACTGGAACCACCTGGACGAAGAGCAGGCC
AGCCCGGACCTCTGGAGTGCCCCCAGCCCAGAGCCCGGTGGGTCCGCATCCCTGCTTCTG
GCGCCCCACCCACCCCACACCTGCAGTGCCAGCTCCCTCGTCTTCAGCTGCATTTCACAT
GCCTTGCAATGGATCAGCCAAGGCCGAGACCCCATCTTCCAGCCACCTAGTCCCCCAAAG
GGCCTCCTCACCCACCCTGTGGCTCACAGTGGGGCCAGCATACTCCGTGAGGCTGCTGCC
ATCCATGTGCTAGTCACTGGCAGCCTGCACCTGGTGGGTGGTGTCCTGAAGCTGCTGGAG
CCCGCACTGTCCCAGTAG

# Metabolic_Enzyme_8_GenBank_ID_Gene:
M98045

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_8_Locus:
9q34.1

# Metabolic_Enzyme_8_SNPs:
rs10760502; rs34354111; rs7856096; rs10106; rs955171; rs1042304; rs7027767; rs7868117; rs1966227; rs4451422; rs12005665; rs10732395; rs28570299; rs11790075; rs17855900; rs12686275; rs2230270; rs41306702; rs35789560; rs34330923; rs11554717; rs1042320; rs2183471; rs10120483; rs10987742; rs41307463; rs10122277; rs7854264; rs34756461; rs10987745; rs34570466; rs10987744; rs3926812; rs5900768; rs10819307; rs12004468; rs35024559; rs35879553; rs7847684; rs10122348; rs35214573; rs10987743; rs10671024; rs9632913; rs35903231; rs35342422; rs10122345; rs9802255; rs11414140; rs10987741; rs36204713; rs36204705; rs36204709; rs10118903; rs36204707; rs36204706; rs36204712; rs34601856; rs10117208; rs10120784; rs10264; rs1054775; rs10760503; rs10819309; rs10987734; rs10987735; rs10987736; rs10987737; rs10987740; rs10987746; rs12001427; rs12379987; rs13300241; rs1330683; rs1330684; rs1544105; rs15630; rs34116890; rs34828244; rs4338213; rs5031024; rs5031025; rs5031026; rs5031027; rs6478796; rs7018778; rs7024560; rs7033913; rs7039798

# Metabolic_Enzyme_8_General_References:
1409616; 7721888; 8521387; 3828320

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
6131

# Metabolic_Enzyme_9_Name:
Alanine aminotransferase 1

# Metabolic_Enzyme_9_Synonyms:
ALT1; Glutamic--pyruvic transaminase 1; GPT 1; Glutamic--alanine transaminase 1

# Metabolic_Enzyme_9_Gene_Name:
GPT

# Metabolic_Enzyme_9_Protein_Sequence:
>Alanine aminotransferase 1
MASSTGDRSQAVRHGLRAKVLTLDGMNPRVRRVEYAVRGPIVQRALELEQELRQGVKKPF
TEVIRANIGD
AQAMGQRPITFLRQVLALCVNPDLLSSPNFPDDAKKRAERILQACGGHS
LGAYSVSSGIQLIREDVARYI
ERRDGGIPADPNNVFLSTGASDAIVTVLKLLVAGEGHT
RTGVLIPIPQYPLYSATLAELGAVQVDYYLDE
ERAWALDVAELHRALGQARDHCRPRAL
CVINPGNPTGQVQTRECIEAVIRFAFEERLFLLADEVYQDNVY
AAGSQFHSFKKVLMEM
GPPYAGQQELASFHSTSKGYMGECGFRGGYVEVVNMDAAVQQQMLKLMSVRLCP
PVPGQ
ALLDLVVSPPAPTDPSFAQFQAEKQAVLAELAAKAKLTEQVFNEAPGISCNPVQGAMYSF
PRVQL
PPRAVERAQELGLAPDMFFCLRLLEETGICVVPGSGFGQREGTYHFRMTILPPL
EKLRLLLEKLSRFHAK
FTLEYS

# Metabolic_Enzyme_9_Number_of_Residues:
496

# Metabolic_Enzyme_9_Molecular_Weight:
54638

# Metabolic_Enzyme_9_Theoretical_pI:
7.20

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-sulfur lyase activity
Function:  1-aminocyclopropane-1-carboxylate synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles

# Metabolic_Enzyme_9_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00710  Carbon fixation

# Metabolic_Enzyme_9_Reaction:
L-alanine + 2-oxoglutarate = pyruvate + L-glutamate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.6.1.2

# Metabolic_Enzyme_9_GenBank_ID_Protein:
1763096

# Metabolic_Enzyme_9_SwissProt_ID:
ALAT1_HUMAN (P24298)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
GPT

# Metabolic_Enzyme_9_Geneatlas_id:
GPT

# Metabolic_Enzyme_9_hgnc_id:
HGNC:4552

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_9_Gene_Sequence:
>1491 bp

ATGGCCTCGAGCACAGGTGACCGGAGCCAGGCGGTGAGGCATGGACTGAGGGCGAAGGT
GCTGACGCTGG
ACGGCATGAACCCGCGTGTGCGGAGAGTGGAGTACGCAGTGCGTGGCC
CCATAGTGCAGCGAGCCTTGGA
GCTGGAGCAGGAGCTGCGCCAGGGTGTGAAGAAGCCT
TTCACCGAGGTCATCCGTGCCAACATCGGGGAC
GCACAGGCTATGGGGCAGAGGCCCAT
CACCTTCCTGCGCCAGGTCTTGGCCCTCTGTGTTAACCCTGATC
TTCTGAGCAGCCCCA
ACTTCCCTGACGATGCCAAGAAAAGGGCGGAGCGCATCTTGCAGGCGTGTGGGGG
CCAC
AGTCTGGGGGCCTACAGCGTCAGCTCCGGCATCCAGCTGATCCGGGAGGACGTGGCGCGG
TACATT
GAGAGGCGTGACGGAGGCATCCCTGCGGACCCCAACAACGTCTTCCTGTCCAC
AGGGGCCAGCGATGCCA
TCGTGACGGTGCTGAAGCTGCTGGTGGCCGGCGAGGGCCACA
CACGCACGGGTGTGCTCATCCCCATCCC
CCAGTACCCACTCTACTCGGCCACGCTGGCA
GAGCTGGGCGCAGTGCAGGTGGATTACTACCTGGACGAG
GAGCGTGCCTGGGCGCTGGA
CGTGGCCGAGCTTCACCGTGCACTGGGCCAGGCGCGTGACCACTGCCGCC
CTCGTGCGC
TCTGTGTCATCAACCCTGGCAACCCCACCGGGCAGGTGCAGACCCGCGAGTGCATCGAGG
C
CGTGATCCGCTTCGCCTTCGAAGAGCGGCTCTTTCTGCTGGCGGACGAGGTGTACCAG
GACAACGTGTAC
GCCGCGGGTTCGCAGTTCCACTCATTCAAGAAGGTGCTCATGGAGAT
GGGGCCGCCCTACGCCGGGCAGC
AGGAGCTTGCCTCCTTCCACTCCACCTCCAAGGGCT
ACATGGGCGAGTGCGGGTTCCGCGGCGGCTATGT
GGAGGTGGTGAACATGGACGCTGCA
GTGCAGCAGCAGATGCTGAAGCTGATGAGTGTGCGGCTGTGCCCG
CCGGTGCCAGGACA
GGCCCTGCTGGACCTGGTGGTCAGCCCGCCCGCGCCCACCGACCCCTCCTTTGCGC
AGT
TCCAGGCTGAGAAGCAGGCAGTGCTGGCAGAGCTGGCGGCCAAGGCCAAGCTCACCGAGC
AGGTCTT
CAATGAGGCTCCTGGCATCAGCTGCAACCCAGTGCAGGGCGCCATGTACTCC
TTCCCGCGCGTGCAGCTG
CCCCCGCGGGCGGTGGAGCGCGCTCAGGAGCTGGGCCTGGC
CCCCGATATGTTCTTCTGCCTGCGCCTCC
TGGAGGAGACCGGCATCTGCGTGGTGCCAG
GGAGCGGCTTTGGGCAGCGGGAAGGCACCTACCACTTCCG
GATGACCATTCTGCCCCCC
TTGGAGAAACTGCGGCTGCTGCTGGAGAAGCTGAGCAGGTTCCATGCCAAG
TTCACCCT
CGAGTACTCCTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
U70732

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_9_Locus:
8q24.3

# Metabolic_Enzyme_9_SNPs:
Not Available

# Metabolic_Enzyme_9_General_References:
9119391; 1931970; 11863375

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5939

# Metabolic_Enzyme_10_Name:
Glutamate dehydrogenase 2, mitochondrial precursor

# Metabolic_Enzyme_10_Synonyms:
GDH

# Metabolic_Enzyme_10_Gene_Name:
GLUD2

# Metabolic_Enzyme_10_Protein_Sequence:
>Glutamate dehydrogenase 2, mitochondrial precursor
MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAARRHYSELVADR
EDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSF
PIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFG
GAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTY
ASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFR
DKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILG
FPKAKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLER
NILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGK
HGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYV
NAIEKVFKVYSEAGVTFT

# Metabolic_Enzyme_10_Number_of_Residues:
558

# Metabolic_Enzyme_10_Molecular_Weight:
61435

# Metabolic_Enzyme_10_Theoretical_pI:
8.67

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_10_Specific_Function:
Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission

# Metabolic_Enzyme_10_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00251  Glutamate metabolism;
 map00330  Arginine and proline metabolism;
 map00471  D-Glutamine and D-glutamate metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_10_Reaction:
L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + ammonia + NAD(P)H + H+

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00208:ELFV_dehydrog;
PF02812:ELFV_dehydrog_N

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 1.4.1.3

# Metabolic_Enzyme_10_GenBank_ID_Protein:
31815

# Metabolic_Enzyme_10_SwissProt_ID:
DHE4_HUMAN (P49448)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
GLUD2

# Metabolic_Enzyme_10_Geneatlas_id:
GLUD2

# Metabolic_Enzyme_10_hgnc_id:
HGNC:4336

# Metabolic_Enzyme_10_PDB_ID:
1L1F

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_10_Gene_Sequence:
>1677 bp
ATGTACCGCTACCTGGCCAAAGCGCTGCTGCCGTCCCGGGCCGGGCCCGCTGCCCTGGGC
TCCGCGGCCAACCACTCGGCCGCGTTGCTGGGCCGGGGCCGCGGACAGCCCGCCGCCGCC
TCGCAGCCGGGGCTCGCATTGGCCGCCCGGCGCCACTACAGCGAGTTGGTGGCCGACCGC
GAGGACGACCCCAACTTCTTCAAGATGGTGGAGGGCTTCTTCGATCGCGGCGCCAGCATC
GTGGAGGACAAGTTGGTGAAGGACCTGAGGACCCAGGAAAGCGAGGAGCAGAAGCGGAAC
CGGGTGCGCGGCATCCTGCGGATCATCAAGCCCTGCAACCATGTGCTGAGTCTCTCCTTC
CCCATCCGGCGCGACGACGGCTCCTGGGAGGTCATCGAAGGCTACCGGGCCCAGCACAGC
CAGCACCGCACGCCCTGCAAGGGAGGTATCCGTTACAGCACTGATGTGAGTGTAGATGAA
GTAAAAGCTTTGGCTTCTCTGATGACATACAAGTGTGCAGTGGTTGATGTGCCGTTTGGG
GGTGCTAAAGCTGGTGTTAAGATCAATCCCAAGAACTATACCGAAAATGAATTGGAAAAG
ATCACAAGGAGGTTCACCATGGAGCTAGCAAAGAAGGGCTTTATTGGTCCTGGCGTTGAT
GTGCCTGCTCCAGACATGAACACAGGTGAGCGGGAGATGTCCTGGATTGCTGATACCTAT
GCCAGCACCATAGGGCACTATGATATTAATGCACACGCCTGTGTTACTGGTAAACCCATC
AGCCAAGGGGGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGGGATT
GAAAACTTCATCAATCAAGCTTCTTACATGAGCATTTTAGGAATGACACCAGGGTTTAGA
GATAAAACATTTGTTGTTCAGGGATTTGGTAATGTGGGCCTACACTCTATGAGATATTTA
CATCGTTTTGGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAATCCA
GATGGTATTGACCCAAAGGAACTGGAAGACTTCAAATTGCAACATGGGTCCATTCTGGGC
TTCCCCAAGGCAAAGCCCTATGAAGGAAGCATCTTGGAGGTCGACTGTGACATACTGATC
CCAGCTGCCACTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAAGATC
ATTGCTGAAGGTGCCAATGGGCCAACAACTCCAGAAGCTGATAAGATCTTCCTGGAGAGA
AACATTTTGGTTATTCCAGATCTCTACTTGAATGCTGGAGGAGTGACAGTATCTTACTTT
GAGTGGCTGAAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGAAAGG
GATTCTAACTACCACTTGCTCCTGTCTGTTCAAGAGAGTTTAGAAAGAAAATTTGGAAAG
CATGGTGGAACTATTCCCATTGTACCCACGGCAGAGTTCCAAGACAGTATATCGGGTGCA
TCTGAGAAAGACATTGTGCACTCTGCCTTGGCATACACAATGGAGCGTTCTGCCAGGCAA
ATTATGCACACAGCCATGAAGTATAACCTGGGATTGGACCTGAGAACAGCTGCCTATGTC
AATGCCATTGAAAAAGTCTTCAAAGTGTACAGTGAAGCTGGTGTGACCTTCACATAG

# Metabolic_Enzyme_10_GenBank_ID_Gene:
X66310

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_10_Locus:
Xq24-q25

# Metabolic_Enzyme_10_SNPs:
rs9697983; rs9780362; rs5909779; rs5911062; rs10657; rs1131121; rs28928873; rs41304944; rs1131120; rs12834131; rs3861; rs5956266; rs34294265; rs5956265; rs9698227; rs12836242; rs17329546; rs2375484; rs5956268; rs9699235; rs9778349

# Metabolic_Enzyme_10_General_References:
8207021

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5855

# Metabolic_Enzyme_11_Name:
Asparagine synthetase [glutamine-hydrolyzing]

# Metabolic_Enzyme_11_Synonyms:
Glutamine- dependent asparagine synthetase; Cell cycle control protein TS11

# Metabolic_Enzyme_11_Gene_Name:
ASNS

# Metabolic_Enzyme_11_Protein_Sequence:
>Asparagine synthetase glutaminehydrolyzing
MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRLAVVDPLFGMQ
PIRVKKYPYLWLCYNGEIYNHKKMQQHFEFEYQTKVDGEIILHLYDKGGIEQTICMLDGV
FAFVLLDTANKKVFLGRDTYGVRPLFKAMTEDGFLAVCSEAKGLVTLKHSATPFLKVEPF
LPGHYEVLDLKPNGKVASVEMVKYHHCRDVPLHALYDNVEKLFPGFEIETVKNNLRILFN
NAVKKRLMTDRRIGCLLSGGLDSSLVAATLLKQLKEAQVQYPLQTFAIGMEDSPDLLAAR
KVADHIGSEHYEVLFNSEEGIQALDEVIFSLETYDITTVRASVGMYLISKYIRKNTDSVV
IFSGEGSDELTQGYIYFHKAPSPEKAEEESERLLRELYLFDVLRADRTTAAHGLELRVPF
LDHRFSSYYLSLPPEMRIPKNGIEKHLLRETFEDSNLIPKEILWRPKEAFSDGITSVKNS
WFKILQEYVEHQVDDAMMANAAQKFPFNTPKTKEGYYYRQVFERHYPGRADWLSHYWMPK
WINATDPSARTLTHYKSAVKA

# Metabolic_Enzyme_11_Number_of_Residues:
561

# Metabolic_Enzyme_11_Molecular_Weight:
64371

# Metabolic_Enzyme_11_Theoretical_pI:
6.85

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  asparagine synthase (glutamine-hydrolyzing) activity
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Function:  asparagine synthase (glutamine-hydrolyzing) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aspartate family amino acid metabolism
Process:  asparagine metabolism
Process:  asparagine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate

# Metabolic_Enzyme_11_Pathway:
map00252  Alanine and aspartate metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_11_Reaction:
ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00733:Asn_synthase;
PF00310:GATase_2

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 6.3.5.4

# Metabolic_Enzyme_11_GenBank_ID_Protein:
179100

# Metabolic_Enzyme_11_SwissProt_ID:
ASNS_HUMAN (P08243)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
ASNS

# Metabolic_Enzyme_11_Geneatlas_id:
ASNS

# Metabolic_Enzyme_11_hgnc_id:
HGNC:753

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Not Available

# Metabolic_Enzyme_11_Gene_Sequence:
>1686 bp
ATGTGTGGCATTTGGGCGCTGTTTGGCAGTGATGATTGCCTTTCTGTTCAGTGTCTGAGT
GCTATGAAGATTGCACACAGAGGTCCAGATGCATTCCGTTTTGAGAATGTCAATGGATAC
ACCAACTGCTGCTTTGGATTTCACCGGTTGGCGGTAGTTGACCCGCTGTTTGGAATGCAG
CCAATTCGAGTGAAGAAATATCCGTATTTGTGGCTCTGTTACAATGGTGAAATCTACAAC
CATAAGAAGATGCAACAGCATTTTGAATTTGAATACCAGACCAAAGTGGATGGTGAGATA
ATCCTTCATCTTTATGACAAAGGAGGAATTGAGCAAACAATTTGTATGTTGGATGGTGTG
TTTGCATTTGTTTTACTGGATACTGCCAATAAGAAAGTGTTCCTGGGTAGAGATACATAT
GGAGTCAGACCTTTGTTTAAAGCAATGACAGAAGATGGATTTTTGGCTGTATGTTCAGAA
GCTAAAGGTCTTGTTACATTGAAGCACTCCGCGACTCCCTTTTTAAAAGTGGAGCCTTTT
CTTCCTGGACACTATGAAGTTTTGGATTTAAAGCCAAATGGCAAAGTTGCATCCGTGGAA
ATGGTTAAATATCATCACTGTCGGGATGTACCCCTGCACGCCCTCTATGACAATGTGGAG
AAACTCTTTCCAGGTTTTGAGATAGAAACTGTGAAGAACAACCTCAGGATCCTTTTTAAT
AATGCTGTAAAGAAACGTTTGATGACAGACAGAAGGATTGGCTGCCTTTTATCAGGGGGC
TTGGACTCCAGCTTGGTTGCTGCCACTCTGTTGAAGCAGCTGAAAGAAGCCCAAGTACAG
TATCCTCTCCAGACATTTGCAATTGGCATGGAAGACAGCCCCGATTTACTGGCTGCTAGA
AAGGTGGCAGATCATATTGGAAGTGAACATTATGAAGTCCTTTTTAACTCTGAGGAAGGC
ATTCAGGCTCTGGATGAAGTCATATTTTCCTTGGAAACTTATGACATTACAACAGTTCGT
GCTTCAGTAGGTATGTATTTAATTTCCAAGTATATTCGGAAGAACACAGATAGCGTGGTG
ATCTTCTCTGGAGAAGGATCAGATGAACTTACGCAGGGTTACATATATTTTCACAAGGCT
CCTTCTCCTGAAAAAGCCGAGGAGGAGAGTGAGAGGCTTCTGAGGGAACTCTATTTGTTT
GATGTTCTCCGCGCAGATCGAACTACTGCTGCCCATGGTCTTGAACTGAGAGTCCCATTT
CTAGATCATCGATTTTTTTCCTATTACTTGTCTCTGCCACCAGAAATGAGAATTCCAAAG
AATGGGATAGAAAAACATCTCCTGAGAGAGACGTTTGAGGATTCCAATCTGATACCCAAA
GAGATTCTCTGGCGACCAAAAGAAGCCTTCAGTGATGGAATAACTTCAGTTAAGAATTCC
TGGTTTAAGATTTTACAGGAATACGTTGAACATCAGGTTGATGATGCAATGATGGCAAAT
GCAGCCCAGAAATTTCCCTTCAATACTCCTAAAACCAAAGAAGGATATTACTACCGTCAA
GTCTTTGAACGCCATTACCCAGGCCGGGCTGACTGGCTGAGCCATTACTGGATGCCCAAG
TGGATCAATGCCACTGACCCTTCTGCCCGCACGCTGACCCACTACAAGTCAGCTGTCAAA
GCTTAG

# Metabolic_Enzyme_11_GenBank_ID_Gene:
M27396

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_11_Locus:
7q21.3

# Metabolic_Enzyme_11_SNPs:
rs1049674; rs6465630; rs7800135; rs4727378; rs7790127; rs11486966; rs11771498; rs17345759; rs17169191; rs3735557; rs11767463; rs17169211; rs17169200; rs3832527; rs17169208; rs2237287; rs7810919; rs7781469; rs10253639; rs12704947; rs7792744; rs1017070; rs7811643; rs2074891; rs7797354; rs2394741; rs4729386; rs4727377; rs17169185; rs4729388; rs17279084; rs2237289; rs17344752; rs12113193; rs4568556; rs1986082; rs10486011; rs10263979; rs2302088; rs11768092; rs13239311; rs10278321; rs17169184; rs7779490; rs12669125; rs4634561; rs17345286; rs7810492; rs17131823; rs11773753; rs4729387; rs17169186; rs11976728; rs1974562; rs3757674; rs10447748; rs3757676; rs3757675; rs17169214; rs7803055; rs12670261; rs12672215; rs13224424; rs2070159; rs11554428; rs3179866; rs1803163; rs11554429; rs11554431; rs1049677; rs3735556; rs34050735; rs11554430; rs35467050; rs34856818; rs3832526; rs13227174; rs34170799; rs28525152; rs10261245; rs6959868; rs28505181; rs36063366; rs13437661; rs10231594; rs35910902; rs28393117; rs13240259; rs28681292; rs41278833; rs2237288; rs12704948; rs13227443; rs41278827; rs10281896; rs28576085; rs10277835; rs36021744; rs13227408; rs41278830; rs10261265; rs41278824; rs13227432; rs35525774; rs12671902; rs13227317; rs13227319; rs34781568; rs13235208; rs35358974; rs35190368; rs34980123; rs28568790; rs13237150; rs36101543; rs36145892; rs13311082; rs12668015; rs28675065; rs35939272; rs34857173; rs10486009; rs10486010; rs11975817; rs13230541; rs2530121; rs6966699; rs7798362; rs7800746; rs9641216

# Metabolic_Enzyme_11_General_References:
2886907; 2565875; 12853948; 3470743; 2569668; 2564390; 2573597

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5967

# Metabolic_Enzyme_12_Name:
Glutamate dehydrogenase 1, mitochondrial precursor

# Metabolic_Enzyme_12_Synonyms:
GDH

# Metabolic_Enzyme_12_Gene_Name:
GLUD1

# Metabolic_Enzyme_12_Protein_Sequence:
>Glutamate dehydrogenase 1, mitochondrial precursor
MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPGLALAARRHYSEAVADR
EDDPNFFKMVEGFFDRGASIVEDKLVEDLRTRESEEQKRNRVRGILRIIKPCNHVLSLSF
PIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFG
GAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTY
ASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFG
DKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILG
FPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLER
NIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGK
HGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYV
NAIEKVFKVYNEAGVTFT

# Metabolic_Enzyme_12_Number_of_Residues:
558

# Metabolic_Enzyme_12_Molecular_Weight:
61399

# Metabolic_Enzyme_12_Theoretical_pI:
7.91

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_12_Specific_Function:
May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate

# Metabolic_Enzyme_12_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00251  Glutamate metabolism;
 map00330  Arginine and proline metabolism;
 map00471  D-Glutamine and D-glutamate metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_12_Reaction:
L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + ammonia + NAD(P)H + H+

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00208:ELFV_dehydrog;
PF02812:ELFV_dehydrog_N

# Metabolic_Enzyme_12_Signals:
1-20

# Metabolic_Enzyme_12_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 1.4.1.3

# Metabolic_Enzyme_12_GenBank_ID_Protein:
31707

# Metabolic_Enzyme_12_SwissProt_ID:
DHE3_HUMAN (P00367)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
GLUD1

# Metabolic_Enzyme_12_Geneatlas_id:
GLUD1

# Metabolic_Enzyme_12_hgnc_id:
HGNC:4335

# Metabolic_Enzyme_12_PDB_ID:
1L1F

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_12_Gene_Sequence:
>1677 bp
ATGTACCGCTACCTGGGCGAAGCGCTGTTGCTGTCCCGGGCCGGGCCCGCTGCCCTGGGC
TCGGCGTCCGCCGACTCGGCCGCGTTGCTGGGCTGGGCCCGGGGACAGCCCGCCGCCGCC
CCGCAGCCGGGGCTGGCATTGGCCGCCCGGCGCCACTACAGCGAGGCGGTGGCCGACCGC
GAGGACGACCCCAACTTCTTCAAGATGGTGGAGGGCTTCTTCGATCGCGGCGCCAGCATC
GTGGAGGACAAGCTGGTGGAGGACCTGAGGACCCGGGAGAGCGAGGAGCAGAAGCGGAAC
CGGGTGCGCGGCATCCTGCGGATCATCAAGCCCTGCAACCATGTGCTGAGTCTCTCCTTC
CCCATCCGGCGCGACGACGGCTCCTGGGAGGTCATCGAAGGCTACCGGGCCCAGCACAGC
CAGCACCGCACGCCCTGCAAGGGAGGTATCCGTTACAGCACTGATGTGAGTGTAGATGAA
GTAAAAGCTTTGGCTTCTCTGATGACATACAAGTGTGCAGTGGTTGATGTGCCGTTTGGG
GGTGCTAAAGCTGGTGTTAAGATCAATCCCAAGAACTATACTGATAATGAATTGGAAAAG
ATCACAAGGAGGTTCACCATGGAGCTAGCAAAAAAGGGCTTTATTGGTCCTGGCATTGAT
GTGCCTGCTCCAGACATGAGCACAGGTGAGCGGGAGATGTCCTGGATCGCTGATACCTAT
GCCAGCACCATAGGGCACTATGATATTAATGCACACGCCTGTGTTACTGGTAAACCCATC
AGCCAAGGGGGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGGGATT
GAAAATTTCATCAATGAAGCTTCTTACATGAGCATTTTAGGAATGACACCAGGGTTTGGA
GATAAAACATTTGTTGTTCAGGGATTTGGTAATGTGGGCCTACACTCTATGAGATATTTA
CATCGTTTTGGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAATCCA
GATGGTATTGACCCAAAGGAACTGGAAGACTTCAAATTGCAACATGGGTCCATTCTGGGC
TTCCCCAAGGCAAAGCCCTATGAAGGAAGCATCTTGGAGGCCGACTGTGACATACTGATC
CCAGCTGCCAGTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAAGATC
ATTGCTGAAGGTGCCAATGGGCCAACAACTCCAGAAGCTGACAAGATCTTCCTGGAGAGA
AACATTATGGTTATTCCAGATCTCTACTTGAATGCTGGAGGAGTGACAGTATCTTACTTT
GAGTGGCTGAAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGAAAGG
GATTCTAACTACCACTTGCTCATGTCTGTTCAAGAGAGTTTAGAAAGAAAATTTGGAAAG
CATGGTGGAACTATTCCCATTGTACCCACGGCAGAGTTCCAAGACAGGATATCGGGTGCA
TCTGAGAAAGACATCGTGCACTCTGGCTTGGCATACACAATGGAGCGTTCTGCCAGGCAA
ATTATGCGCACAGCCATGAAGTATAACCTGGGATTGGACCTGAGAACAGCTGCCTATGTT
AATGCCATTGAGAAAGTCTTCAAAGTGTACAATGAAGCTGGTGTGACCTTCACATAG

# Metabolic_Enzyme_12_GenBank_ID_Gene:
X07674

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_12_Locus:
10q23.3

# Metabolic_Enzyme_12_SNPs:
rs2181522; rs1923939; rs2296061; rs7083075; rs6586053; rs9420432; rs2296063; rs7903935; rs7069764; rs12416157; rs7098123; rs4934292; rs7068848; rs9421580; rs7077790; rs9421571; rs10887689; rs17107329; rs9421579; rs9420431; rs4933427; rs9421573; rs7072835; rs2146720; rs7080134; rs4934294; rs4460731; rs12414004; rs12778953; rs7076542; rs9421574; rs17107324; rs17343630; rs4275529; rs10887688; rs7090928; rs11202313; rs4460730; rs6586054; rs1923933; rs7076857; rs11202328; rs7895873; rs9420434; rs4491135; rs4934295; rs12257719; rs10887690; rs7085236; rs11202311; rs17343324; rs745224; rs1050340; rs1050359; rs1050306; rs1050319; rs11548293; rs3190657; rs12980; rs1803640; rs9420433; rs11202315; rs3204151; rs33966755; rs11453443; rs11202318; rs7096113; rs9421575; rs9421578; rs34096944; rs34237834; rs41448647; rs34610047; rs4933426; rs11306284; rs7903094; rs11202326; rs34760005; rs4370842; rs9732169; rs12781507; rs35027759; rs11202314; rs5786757; rs12761256; rs28590183; rs3204153; rs1923935; rs1923934; rs11202321; rs7075538; rs11202316; rs5786756; rs7478413; rs7911871; rs4934293; rs10544932; rs28581586; rs11202327; rs35275424; rs9421577; rs11202320; rs12416344; rs34141032; rs36124172; rs7067639; rs10565916; rs11202323; rs12763774; rs7069518; rs11202319; rs7083943; rs11202324; rs9421576; rs1923937; rs9421581; rs4244974; rs35186250; rs12256112; rs7089351; rs34165463; rs9420430; rs11272037; rs1923936; rs11202322; rs28621802; rs12778122; rs4934296; rs12256919; rs9651489; rs3204150; rs36079084; rs10909633; rs12266578; rs10655872; rs12763347; rs10535860; rs11202317; rs7096107; rs11345875; rs7923785; rs35002136; rs34156521; rs11202325; rs35811908; rs11431413; rs1923938; rs35075180; rs11428350; rs34933272; rs5786753; rs9421569; rs9420429; rs35924180; rs34324523; rs34307641; rs34369587; rs1050156; rs11202310; rs12251095; rs2296062; rs4430417

# Metabolic_Enzyme_12_General_References:
3426581; 3377777; 3399399; 3368458; 8486350; 429360; 1286669; 3585334; 8314555; 11254391; 11903050; 12054821; 12653548; 10338089; 9571255; 10636977; 11214910; 11297618

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5516

# Metabolic_Enzyme_13_Name:
Aspartate aminotransferase, mitochondrial precursor

# Metabolic_Enzyme_13_Synonyms:
Transaminase A; Glutamate oxaloacetate transaminase 2

# Metabolic_Enzyme_13_Gene_Name:
GOT2

# Metabolic_Enzyme_13_Protein_Sequence:
>Aspartate aminotransferase, mitochondrial precursor
MALLHSGRVLPGIAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEAFKRDTNSKKM
NLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENSEV
LKSGRFVTVQTISGTGALRIGASFLQRFFKFSRDVFLPKPTWGNHTPIFRDAGMQLQGYR
YYDPKTCGFDFTGAVEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIATVVKKRNLFA
FFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTMVCKDADE
AKRVESQLKILIRPMYSNPPLNGARIAAAILNTPDLRKQWLQEVKGMADRIIGMRTQLVS
NLKKEGSTHNWQHITDQIGMFCFTGLKPEQVERLIKEFSIYMTKDGRISVAGVTSSNVGY
LAHAIHQVTK

# Metabolic_Enzyme_13_Number_of_Residues:
430

# Metabolic_Enzyme_13_Molecular_Weight:
47476

# Metabolic_Enzyme_13_Theoretical_pI:
9.38

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  transaminase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_13_Specific_Function:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_13_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00272  Cysteine metabolism;
 map00330  Arginine and proline metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00401  Novobiocin biosynthesis;
 map00710  Carbon fixation;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_13_Reaction:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_13_Signals:
1-24

# Metabolic_Enzyme_13_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 2.6.1.1

# Metabolic_Enzyme_13_GenBank_ID_Protein:
179104

# Metabolic_Enzyme_13_SwissProt_ID:
AATM_HUMAN (P00505)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
GOT2

# Metabolic_Enzyme_13_Geneatlas_id:
GOT2

# Metabolic_Enzyme_13_hgnc_id:
HGNC:4433

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_13_Gene_Sequence:
>1293 bp
ATGGCCCTGCTGCACTCCGGCCGCGTCCTCCCCGGGATCGCCGCCGCCTTCCACCCGGGC
CTCGCCGCCGCGGCCTCTGCCAGAGCCAGCTCCTGGTGGACCCATGTGGAAATGGGACCT
CCAGATCCCATTCTGGGAGTCACTGAAGCCTTTAAGAGGGACACCAATAGCAAAAAGATG
AATCTGGGAGTTGGTGCCTACCGGGATGATAATGGAAAGCCTTACGTTCTGCCTAGCGTC
CGCAAGGCAGAGGCCCAGATTGCCGCAAAAAATTTGGACAAGGAATACCTGCCCATTGGG
GGACTGGCTGAATTTTGCAAGGCATCTGCAGAACTAGCCCTGGGTGAGAACAGCGAAGTC
TTGAAGAGTGGCCGGTTTGTCACTGTGCAGACCATTTCTGGAACTGGAGCCTTAAGGATC
GGAGCCAGTTTTCTGCAAAGATTTTTTAAGTTCAGCCGAGATGTCTTTCTGCCCAAACCA
ACCTGGGGAAACCACACACCCATCTTCAGGGATGCTGGCATGCAGCTACAAGGTTATCGG
TATTATGACCCCAAGACTTGCGGTTTTGACTTCACAGGCGCTGTGGAGGATATTTCAAAA
ATACCAGAGCAGAGTGTTCTTCTTCTGCATGCCTGCGCCCACAATCCCACGGGAGTGGAC
CCGCGTCCGGAACAGTGGAAGGAAATAGCAACAGTGGTGAAGAAAAGGAATCTCTTTGCG
TTCTTTGACATGGCCTACCAAGGCTTTGCCAGTGGTGATGGTGATAAGGATGCCTGGGCT
GTGCGCCACTTCATCGAACAGGGCATTAATGTTTGCCTCTGCCAATCATATGCCAAGAAC
ATGGGCTTATATGGTGAGCGTGTAGGAGCCTTCACTATGGTCTGCAAAGATGCGGATGAA
GCCAAAAGGGTAGAGTCACAGTTGAAGATCTTGATCCGTCCCATGTATTCCAACCCTCCC
CTCAATGGGGCCCGGATTGCTGCTGCCATTCTGAACACCCCAGATTTGCGAAAACAATGG
CTGCAAGAAGTGAAAGGCATGGCTGACCGCATCATTGGCATGCGGACTCAACTGGTCTCC
AACCTCAAGAAGGAGGGTTCCACCCACAATTGGCAACACATCACCGACCAAATTGGCATG
TTCTGTTTCACAGGGCTAAAGCCTGAACAGGTGGAGCGGCTGATCAAGGAGTTCTCCATC
TACATGACAAAAGATGGCCGCATCTCTGTGGCAGGGGTCACCTCCAGCAACGTGGGCTAC
CTTGCCCATGCCATTCACCAGGTCACCAAGTAA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
M22632

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_13_Locus:
16q21

# Metabolic_Enzyme_13_SNPs:
rs30842; rs11076256; rs257636; rs6993; rs7202491; rs11861897; rs257620; rs863944; rs6499971; rs30838; rs30839; rs7204324; rs257616; rs257630; rs1646256; rs8060056; rs6499970; rs30834; rs257617; rs185397; rs257634; rs12600277; rs257618; rs2304490; rs7196291; rs30837; rs9921563; rs1610878; rs4784975; rs9926132; rs257637; rs1646267; rs257631; rs13334922; rs1424245; rs30836; rs190473; rs257633; rs7186087; rs30835; rs173992; rs10500407; rs257649; rs187277; rs9926863; rs40574; rs183757; rs30843; rs1657179; rs7189519; rs1657178; rs2042445; rs7188608; rs257650; rs1803169; rs17849335; rs11558171; rs8059441; rs1058192; rs14221; rs11558167; rs1803168; rs28612351; rs3208672; rs1803170; rs7186105; rs35645687; rs5817158; rs11333258; rs34912264; rs10676089; rs1436429; rs35946557; rs4784974; rs8047219; rs12922626; rs34509416; rs257632; rs35502495; rs12919184; rs7184964; rs9934653; rs9921588; rs4784976; rs13334281; rs9921474; rs12597424; rs7185829; rs13330819; rs28497727; rs34526718; rs7204346; rs3217426; rs11348341; rs34853918; rs257621; rs30840; rs34039790; rs35247174; rs13337034; rs34792826; rs171786; rs30841; rs1657182; rs34180921; rs9923914; rs12921667; rs12933313; rs11299978; rs8046165; rs35323432; rs11423426; rs12932751; rs9933525; rs7186806; rs34289635; rs35324915; rs11439864; rs8046634; rs40575; rs11445492; rs28463297; rs5817159; rs35679170; rs34405351; rs9927670; rs257619; rs35298154; rs3743573; rs8045857; rs9933114; rs8044891; rs35125089; rs35939343; rs7187269; rs257638; rs7194323; rs12923759; rs28472773; rs839418; rs35327432; rs7189104; rs4273028; rs7199783; rs1646260; rs10563758; rs11643959; rs11644269; rs11644290; rs11647748; rs11647808; rs11859875; rs1473205; rs1473206; rs154435; rs1616798; rs1646268; rs3931747; rs4238801; rs4784054; rs4784977; rs6499969; rs7195214; rs7197245

# Metabolic_Enzyme_13_General_References:
3207426; 4052435

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
6132

# Metabolic_Enzyme_14_Name:
Phosphoserine aminotransferase

# Metabolic_Enzyme_14_Synonyms:
PSAT

# Metabolic_Enzyme_14_Gene_Name:
PSAT1

# Metabolic_Enzyme_14_Protein_Sequence:
>Phosphoserine aminotransferase
MDAPRQVVNFGPGPAKLPHSVLLEIQKELLDYKGVGISVLEMSHRSSDFAKIINNTENLV
RELLAVPDNYKVIFLQGGGCGQFSAVPLNLIGLKAGRCADYVVTGAWSAKAAEEAKKFGT
INIVHPKLGSYTKIPDPSTWNLNPDASYVYYCANETVHGVEFDFIPDVKGAVLVCDMSSN
FLSKPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLGFALRECPSVLEYKVQAGNSSLY
NTPPCFSIYVMGLVLEWIKNNGGAAAMEKLSSIKSQTIYEIIDNSQGFYVCPVEPQNRSK
MNIPFRIGNAKGDDALEKRFLDKALELNMLSLKGHRSVGGIRASLYNAVTIEDVQKLAAF
MKKFLEMHQL

# Metabolic_Enzyme_14_Number_of_Residues:
370

# Metabolic_Enzyme_14_Molecular_Weight:
40423

# Metabolic_Enzyme_14_Theoretical_pI:
7.77

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  L-serine metabolism
Process:  L-serine biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
O-phospho-L-serine + 2-oxoglutarate = 3- phosphonooxypyruvate + L-glutamate

# Metabolic_Enzyme_14_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00750  Vitamin B6 metabolism

# Metabolic_Enzyme_14_Reaction:
O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00266:Aminotran_5

# Metabolic_Enzyme_14_Signals:
None

# Metabolic_Enzyme_14_Transmembrane_Regions:
None

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 2.6.1.52

# Metabolic_Enzyme_14_GenBank_ID_Protein:
5326802

# Metabolic_Enzyme_14_SwissProt_ID:
SERC_HUMAN (Q9Y617)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
PSAT1

# Metabolic_Enzyme_14_Geneatlas_id:
PSAT1

# Metabolic_Enzyme_14_hgnc_id:
HGNC:19129

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Not Available

# Metabolic_Enzyme_14_Gene_Sequence:
>975 bp
ATGGACGCCCCCAGGCAGGTGGTCAACTTTGGGCCTGGTCCCGCCAAGCTGCCGCACTCA
GTGTTGTTAGAGATACAAAAGGAATTATTAGACTACAAAGGAGTTGGCATTAGTGTTCTT
GAAATGAGTCACAGGTCATCAGATTTTGCCAAGATTATTAACAATACAGAGAATCTTGTG
CGGGAATTGCTAGCTGTTCCAGACAACTATAAGGTGATTTTTCTGCAAGGAGGTGGGTGC
GGCCAGTTCAGTGCTGTCCCCTTAAACCTCATTGGCTTGAAAGCAGGAAGGTGTGCGGAC
TATGTGGTGACAGGAGCTTGGTCAGCTAAGGCCGCAGAAGAAGCCAAGAAGTTTGGGACT
ATAAATATCGTTCACCCTAAACTTGGGAGTTATACAAAAATTCCAGATCCAAGCACCTGG
AACCTCAACCCAGATGCCTCCTACGTGTATTATTGCGCAAATGAGACGGTGCATGGTGTG
GAGTTTGACTTTATACCCGATGTCAAGGGAGCAGTACTGGTTTGTGACATGTCCTCAAAC
TTCCTGTCCAAGCCAGTGGATGTTTCCAAGTTTGGTGTGATTTTTGCTGGTGCCCAGAAG
AATGTTGGCTCTGCTGGGGTCACCGTGGTGATTGTCCGTGATGACCTGCTGGGGTTTGCC
CTCCGAGAGTGCCCCTCGGTCCTGGAATACAAGGTGCAGGCTGGAAACAGCTCCTTGTAC
AACACGCCTCCATGTTTCAGCATCTACGTCATGGGCTTGGTTCTGGAGTGGATTAAAAAC
AATGGAGGTGCCGCGGCCATGGAGAAGCTTAGCTCCATCAAATCTCAAACAATTTATGAG
ATTATTGATAATTCTCAAGGATTCTACGTGTCTGTGGGAGGCATCCGGGCCTCTCTGTAT
AATGCTGTCACAATTGAAGACGTTCAGAAGCTGGCCGCCTTCATGAAAAAATTTTTGGAG
ATGCATCAGCTATGA

# Metabolic_Enzyme_14_GenBank_ID_Gene:
AF113132

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_14_Locus:
9q21.2

# Metabolic_Enzyme_14_SNPs:
rs3739474; rs2277148; rs17064358; rs10867185; rs944514; rs944516; rs867376; rs944513; rs1411918; rs867377; rs7038086; rs4877587; rs3758200; rs11792782; rs10780231; rs7855063; rs7859163; rs7037526; rs3758201; rs7028509; rs4877586; rs3758202; rs3739475; rs10780229; rs4877548; rs11137607; rs944515; rs4877550; rs3758203; rs4877549; rs3780192; rs11137603; rs7032591; rs10116231; rs7047464; rs11137594; rs3780191; rs10867184; rs6559375; rs10735531; rs11137591; rs3780193; rs10867182; rs10867179; rs4877173; rs10867183; rs3780194; rs4399009; rs10735532; rs7874921; rs7028807; rs7858423; rs11137601; rs10867178; rs3824360; rs10116267; rs2039324; rs17064306; rs7849813; rs10780230; rs11137606; rs3739473; rs10867181; rs3739476; rs7858637; rs7043123; rs1537173; rs4877172; rs2039323; rs10746572; rs10867180; rs7874774; rs7018865; rs867378; rs7870991; rs7043667; rs13288438; rs11137596; rs17064299; rs11137602; rs7858854; rs10121107; rs2039326; rs1929401; rs1411917; rs1929399; rs7875271; rs11137595; rs11137597; rs17064350; rs12348970; rs4877546; rs6559373; rs7865732; rs7870987; rs12343822; rs2039322; rs11137598; rs883815; rs1411916; rs10746571; rs10114791; rs10780228; rs3739472; rs6559374; rs7851021; rs3824361; rs7855608; rs28702747; rs2039325; rs17064352; rs17787876; rs11137599; rs1929400; rs4387052; rs3808906; rs17725890; rs4378035; rs3824548; rs4529534; rs4529535; rs3808905; rs11540973; rs11540974; rs41277897; rs41277903; rs41277905; rs11137605; rs13288572; rs4373597; rs12238510; rs13284284; rs34154867; rs11386563; rs41277899; rs7038041; rs17064304; rs13284147; rs7470974; rs34788504; rs34224073; rs35927698; rs34633837; rs34738292; rs5898581; rs34798179; rs13284173; rs13297474; rs34894701; rs3837223; rs12342174; rs3842207; rs34164682; rs35130135; rs13288446; rs35610246; rs12335648; rs3739471; rs7867978; rs11137592; rs35523947; rs12555058; rs11137600; rs5898580; rs7864809; rs4877171; rs7864810; rs12555669; rs10124569; rs11998878; rs12335643; rs34879641; rs7862389; rs35679003; rs34617794; rs7849829; rs12343612; rs11787717; rs12335649; rs35802652; rs953813; rs13284696; rs33912690; rs13299357; rs4877545; rs11137593; rs35001066; rs11137604; rs13288791; rs36052802; rs34895578; rs3010673; rs13283572; rs35733027; rs12379053; rs5898579; rs4877166; rs4523338; rs3840744; rs34062783; rs10429454; rs10429593; rs10867173; rs10867174; rs10867175; rs10867176; rs10867177; rs11137587; rs11137589; rs11788995; rs11792643; rs12002706; rs12237083; rs12347080; rs1332023; rs17197144; rs17197165; rs2776859; rs3010758; rs7044646; rs7873943

# Metabolic_Enzyme_14_General_References:
12633500

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5760

# Metabolic_Enzyme_15_Name:
Glutamate--cysteine ligase regulatory subunit

# Metabolic_Enzyme_15_Synonyms:
Gamma- glutamylcysteine synthetase; Gamma-ECS; GCS light chain; Glutamate--cysteine ligase modifier subunit

# Metabolic_Enzyme_15_Gene_Name:
GCLM

# Metabolic_Enzyme_15_Protein_Sequence:
>Glutamatecysteine ligase regulatory subunit
MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINP
DLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVA
QLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQ
VKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIQAH
EWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS

# Metabolic_Enzyme_15_Number_of_Residues:
274

# Metabolic_Enzyme_15_Molecular_Weight:
30727

# Metabolic_Enzyme_15_Theoretical_pI:
5.91

# Metabolic_Enzyme_15_GO_Classification:
Not Available

# Metabolic_Enzyme_15_General_Function:
Not Available

# Metabolic_Enzyme_15_Specific_Function:
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

# Metabolic_Enzyme_15_Pathway:
map00251  Glutamate metabolism;
 map00480  Glutathione metabolism

# Metabolic_Enzyme_15_Reaction:
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

# Metabolic_Enzyme_15_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_15_Signals:
None

# Metabolic_Enzyme_15_Transmembrane_Regions:
None

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 6.3.2.2

# Metabolic_Enzyme_15_GenBank_ID_Protein:
530137

# Metabolic_Enzyme_15_SwissProt_ID:
GSH0_HUMAN (P48507)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
GCLM

# Metabolic_Enzyme_15_Geneatlas_id:
GCLM

# Metabolic_Enzyme_15_hgnc_id:
HGNC:4312

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Not Available

# Metabolic_Enzyme_15_Gene_Sequence:
>825 bp
ATGGGCACCGACAGCCGCGCGGCCAAGGCGCTCCTGGCGCGGGCCCGCACCCTGCACCTG
CAGACGGGGAACCTGCTGAACTGGGGCCGCCTGCGGAAGAAGTGCCCGTCCACGCACAGC
GAGGAGCTTCATGATTGTATCCAAAAAACCTTGAATGAATGGAGTTCCCAAATCAACCCA
GATTTGGTCAGGGAGTTTCCAGATGTCTTGGAATGCACTGTATCTCATGCAGTAGAAAAG
ATAAATCCTGATGAAAGAGAAGAAATGAAAGTTTCTGCAAAACTGTTCATTGTAGAATCA
AACTCTTCATCATCAACTAGAAGTGCAGTTGACATGGCCTGTTCAGTCCTTGGAGTTGCA
CAGCTGGATTCTGTGATCATTGCTTCACCTCCTATTGAAGATGGAGTTAATCTTTCCTTG
GAGCATTTACAGCCTTACTGGGAGGAATTAGAAAACTTAGTTCAGAGCAAAAAGATTGTT
GCCATAGGTACCTCTGATCTAGACAAAACACAGTTGGAACAGCTGTATCAGTGGGCACAG
GTAAAACCAAATAGTAACCAAGTTAATCTTGCCTCCTGCTGTGTGATGCCACCAGATTTG
ACTGCATTTGCTAAACAATTTGACATACAGCTGTTGACTCACAATGATCCAAAAGAACTG
CTTTCTGAAGCAAGTTTCCAAGAAGCTCTTCAGGAAAGCATTCCTGACATTCAAGCGCAC
GAGTGGGTGCCGCTGTGGCTACTGCGGTATTCGGTCATTGTGAAAAGTAGAGGAATTATC
AAATCAAAAGGCTACATTTTACAAGCTAAAAGAAGGGGTTCTTAA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
L35546

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_15_Locus:
1p22.1

# Metabolic_Enzyme_15_SNPs:
rs7549683; rs7513671; rs743119; rs17886277; rs17885307; rs17885169; rs17881908; rs17882741; rs718874; rs2301022; rs6700112; rs3827715; rs718875; rs6702045; rs7515813; rs6541405; rs10874809; rs6667121; rs7517826; rs6680315; rs6702064; rs6692306; rs7515191; rs11165031; rs718873; rs7515991; rs17885151; rs2064764; rs6703130; rs4598495; rs7541690; rs2273406; rs17886352; rs17376966; rs17879487; rs11165033; rs2234729; rs7552401; rs17885006; rs3838283; rs17886323; rs11292204; rs17882506; rs12094906; rs17878712; rs12040570; rs17881619; rs17879718; rs17878294; rs17882054; rs12068168; rs12057371; rs17882045; rs17878271; rs17879533; rs769211; rs10629524; rs11292206; rs17882036; rs17879467; rs17880826; rs17878538; rs17886750; rs12410324; rs2234730; rs7527855; rs11165032; rs17884788; rs17886306; rs17878275; rs17880957; rs17882277; rs12140446; rs17879190; rs17881810; rs3789453; rs17879495; rs17884538; rs2391323; rs12068345; rs3170633; rs17884708; rs10489605; rs10874808; rs12073535; rs41303970; rs17884327; rs1803635; rs17880087; rs12062047; rs1803636; rs35267053; rs17878410; rs17880076; rs12401915; rs17878517; rs17883607; rs34905252; rs17886946; rs17886856; rs12094966; rs17878333; rs17884809; rs12143416; rs12760946; rs17886844; rs35618697; rs17878692; rs17886976; rs12741834; rs17878765; rs17879789; rs7522297; rs11383482; rs3068846; rs17886656; rs11587480; rs12064127; rs12062214; rs12089163; rs17880726; rs12090038; rs12730517; rs10618137; rs34743713; rs17878940; rs17882664; rs2273407; rs34865905; rs17879276; rs17883701; rs17884701; rs17878450; rs11283634; rs12090230; rs17884925; rs17879344; rs17885227; rs17879710; rs17881946; rs17881704; rs33913648; rs17878956; rs17881873; rs17880789; rs34098452; rs17886292; rs11589165; rs17886490; rs17879292; rs12062216; rs35224592; rs17882171; rs35940482; rs17879340; rs17879254; rs17884580; rs34585952; rs17879576; rs17881957; rs11314452; rs17878727; rs17880908; rs17878443; rs11310647; rs17885147; rs17887188; rs41292675; rs17887214; rs17880917; rs34914684; rs34068353; rs11292205; rs34571118; rs17880905; rs17882290; rs35171651; rs34212520; rs6689857; rs34088596; rs35508812; rs5776197; rs11461316; rs736762; rs34049489; rs17881483; rs10874804; rs10874805; rs11165029; rs11165030; rs11808380; rs12080386; rs1802708; rs2235970; rs2235971; rs2391322; rs34270983; rs3761912; rs3789457; rs4141736; rs4141737; rs6675820; rs6681078; rs6687387; rs7533596

# Metabolic_Enzyme_15_General_References:
7826375

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
6133

# Metabolic_Enzyme_16_Name:
Alpha-aminoadipic semialdehyde synthase, mitochondrial precursor

# Metabolic_Enzyme_16_Synonyms:
LKR/SDH[Includes: Lysine ketoglutarate reductase; LOR; LKR; Saccharopine dehydrogenase; SDH]

# Metabolic_Enzyme_16_Gene_Name:
AASS

# Metabolic_Enzyme_16_Protein_Sequence:
>Alphaaminoadipic semialdehyde synthase, mitochondrial precursor
MLQVHRTGLGRLGVSLSKGLHHKAVLAVRREDVNAWERRAPLAPKHIKGITNLGYKVLIQ
PSNRRAIHDKDYVKAGGILQEDISEACLILGVKRPPEEKLMSRKTYAFFSHTIKAQEANM
GLLDEILKQEIRLIDYEKMVDHRGVRVVAFGQWAGVAGMINILHGMGLRLLALGHHTPFM
HIGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQAIFNELPC
EYVEPHELKEVSQTGDLRKVYGTVLSRHHHLVRKTDAVYDPAEYDKHPERYISRFNTDIA
PYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKFSPAGVEGCPALPHKLVAICDISADTG
GSIEFMTECTTIEHPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIEATECFGDMLY
PYVEEMILSDATQPLESQNFSPVVRDAVITSNGTLPDKYKYIQTLRESRERAQSLSMGTR
RKVLVLGSGYISEPVLEYLSRDGNIEITVGSDMKNQIEQLGKKYNINPVSMDICKQEEKL
GFLVAKQDLVISLLPYVLHPLVAKACITNKVNMVTASYITPALKELEKSVEDAGITIIGE
LGLDPGLDHMLAMETIDKAKEVGATIESYISYCGGLPAPEHSNNPLRYKFSWSPVGVLMN
VMQSATYLLDGKVVNVAGGISFLDAVTSMDFFPGLNLEGYPNRDSTKYAEIYGISSAHTL
LRGTLRYKGYMKALNGFVKLGLINREALPAFRPEANPLTWKQLLCDLVGISPSSEHDVLK
EAVLKKLGGDNTQLEAAEWLGLLGDEQVPQAESILDALSKHLVMKLSYGPEEKDMIVMRD
SFGIRHPSGHLEHKTIDLVAYGDINGFSAMAKTVGLPTAMAAKMLLDGEIGAKGLMGPFS
KEIYGPILERIKAEGIIYTTQSTIKP

# Metabolic_Enzyme_16_Number_of_Residues:
926

# Metabolic_Enzyme_16_Molecular_Weight:
102133

# Metabolic_Enzyme_16_Theoretical_pI:
6.62

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_16_Specific_Function:
Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively

# Metabolic_Enzyme_16_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_16_Reaction:
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF01262:AlaDh_PNT_C;
PF05222:AlaDh_PNT_N;
PF03435:Saccharop_dh

# Metabolic_Enzyme_16_Signals:
None

# Metabolic_Enzyme_16_Transmembrane_Regions:
None

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 1.5.1.8;EC 1.5.1.9

# Metabolic_Enzyme_16_GenBank_ID_Protein:
7264724

# Metabolic_Enzyme_16_SwissProt_ID:
AASS_HUMAN (Q9UDR5)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
AASS

# Metabolic_Enzyme_16_Geneatlas_id:
AASS

# Metabolic_Enzyme_16_hgnc_id:
HGNC:17366

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_16_Gene_Sequence:
>2781 bp
ATGCTGCAAGTACATAGGACTGGACTGGGCAGGCTGGGGGTCAGCCTCTCCAAGGGTCTT
CACCACAAAGCTGTGTTGGCCGTCCGGAGGGAGGATGTGAACGCCTGGGAGAGAAGGGCC
CCGCTAGCTCCCAAGCACATCAAAGGCATCACCAATCTGGGATACAAGGTCTTGATACAG
CCTTCGAATCGGCGGGCCATTCATGATAAGGACTATGTCAAAGCTGGTGGCATTCTTCAG
GAGGATATTTCTGAAGCTTGTCTAATTTTAGGAGTTAAAAGACCTCCAGAGGAAAAATTA
ATGTCCAGGAAGACTTATGCATTTTTCTCCCACACAATAAAAGCTCAGGAGGCCAATATG
GGCTTGTTGGATGAGATTCTAAAACAGGAAATTCGCCTTATTGATTATGAGAAAATGGTG
GATCATAGAGGAGTACGGGTAGTGGCATTTGGACAGTGGGCTGGTGTGGCAGGAATGATC
AACATTTTACATGGAATGGGTTTAAGGCTCCTTGCTTTGGGACATCACACACCTTTTATG
CACATTGGCATGGCTCATAACTACAGGAATAGCAGTCAGGCTGTGCAAGCTGTCCGTGAT
GCTGGCTATGAAATATCTTTGGGTTTGATGCCTAAGTCAATAGGACCCTTAACATTTGTG
TTCACAGGAACTGGTAATGTTTCTAAGGGAGCCCAAGCAATCTTTAATGAGCTACCTTGT
GAATATGTGGAGCCCCATGAATTAAAAGAAGTTTCCCAAACTGGAGACCTCAGAAAAGTG
TATGGGACGGTGTTAAGTCGTCATCATCATCTTGTCAGGAAAACAGATGCTGTGTATGAT
CCTGCAGAGTATGACAAACATCCGGAGCGCTACATAAGTCGTTTTAATACTGATATTGCA
CCCTATACAACTTGCTTAATTAATGGAATCTACTGGGAACAAAACACTCCTCGCCTCCTA
ACCCGCCAAGATGCTCAGAGTCTCCTGGCTCCGGGCAAGTTCTCACCTGCTGGTGTGGAA
GGCTGCCCTGCATTACCACACAAACTCGTGGCAATATGTGACATTTCAGCTGACACAGGA
GGGTCTATAGAGTTTATGACTGAGTGTACAACAATAGAGCATCCCTTTTGCATGTATGAT
GCAGACCAGCATATTATTCATGACAGTGTTGAAGGCTCGGGGATCCTGATGTGTTCCATT
GACAATTTGCCGGCACAGCTCCCAATTGAAGCTACAGAATGCTTTGGAGACATGCTTTAC
CCTTATGTTGAAGAAATGATATTATCAGACGCGACACAGCCTCTTGAAAGTCAGAATTTT
TCTCCTGTGGTGAGAGATGCAGTGATTACATCCAACGGTACATTACCTGATAAATATAAA
TATATCCAGACACTCCGGGAGAGCAGGGAACGTGCTCAGTCACTTTCAATGGGCACCAGG
AGAAAGGTTTTGGTTCTTGGATCTGGCTACATATCTGAGCCTGTATTAGAATATTTATCA
AGAGATGGCAATATAGAAATAACAGTAGGATCTGACATGAAGAATCAAATTGAACAGTTA
GGCAAGAAATATAATATTAATCCTGTTAGCATGGACATTTGTAAACAAGAAGAGAAGCTG
GGCTTCTTGGTGGCAAAACAGGATCTTGTCATCAGCTTGTTGCCTTATGTATTGCACCCT
CTTGTGGCCAAGGCCTGCATCACAAACAAAGTTAACATGGTCACTGCAAGCTACATCACA
CCAGCACTAAAAGAATTGGAAAAGAGTGTGGAAGATGCTGGCATCACAATCATTGGTGAA
TTGGGATTGGACCCTGGTCTGGATCACATGTTAGCAATGGAAACAATAGATAAAGCCAAG
GAAGTGGGAGCCACGATTGAATCATATATTTCCTACTGTGGTGGGCTTCCAGCCCCTGAA
CATTCAAACAATCCATTGAGATATAAATTTAGCTGGAGTCCAGTGGGAGTTTTGATGAAT
GTAATGCAGTCTGCCACCTATCTGCTCGATGGAAAGGTTGTGAATGTTGCAGGAGGCATC
TCCTTTCTTGATGCCGTTACGTCCATGGATTTTTTTCCAGGATTAAATTTGGAAGGCTAT
CCTAACAGAGACAGTACGAAATATGCTGAGATTTATGGCATTTCTTCTGCTCACACTTTG
TTGCGGGGGACACTGAGATATAAGGGATATATGAAAGCTTTGAATGGATTTGTAAAATTA
GGTCTTATAAACAGAGAAGCGCTTCCTGCCTTTAGACCTGAGGCCAACCCTCTCACCTGG
AAACAACTCCTCTGTGACCTAGTTGGGATTTCACCCTCCTCTGAGCATGATGTGTTGAAG
GAAGCTGTTCTTAAGAAACTAGGAGGAGACAATACCCAGTTGGAGGCTGCTGAATGGTTG
GGCTTACTTGGGGATGAACAAGTTCCTCAGGCAGAGTCCATTCTGGATGCCCTCTCCAAG
CATTTGGTCATGAAGCTTTCCTATGGTCCTGAAGAAAAAGATATGATTGTGATGAGAGAC
AGCTTTGGAATCAGACATCCTTCTGGACATTTAGAACATAAAACGATTGATCTTGTGGCT
TATGGGGACATCAATGGCTTTTCAGCCATGGCTAAAACCGTGGGGTTACCCACCGCCATG
GCAGCCAAAATGTTGCTTGATGGTGAAATTGGAGCCAAAGGCCTAATGGGGCCCTTTTCA
AAGGAGATCTATGGACCAATATTGGAGCGAATTAAAGCAGAAGGCATTATATATACTACA
CAGAGTACAATTAAACCATAA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
AF229180

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_16_Locus:
7q31.3

# Metabolic_Enzyme_16_SNPs:
rs17144072; rs34901960; rs1206361; rs279700; rs279699; rs1206372; rs2016284; rs1725067; rs1860507; rs1875409; rs1206374; rs279665; rs279663; rs4140745; rs2268075; rs1206368; rs6968699; rs12669983; rs2302338; rs1206366; rs2840105; rs279673; rs279701; rs6466812; rs17144099; rs7787099; rs3213699; rs11761176; rs1206367; rs1206362; rs279669; rs279677; rs279674; rs279668; rs279667; rs2134059; rs11771234; rs1206371; rs1206369; rs279680; rs969549; rs279706; rs1206370; rs2268076; rs12671513; rs10236532; rs1725066; rs279666; rs279676; rs279671; rs2268074; rs12532071; rs1405236; rs1206373; rs279664; rs6954861; rs12706384; rs1206375; rs6967194; rs10429059; rs6947355; rs1206376; rs12113399; rs12539675; rs12539712; rs279678; rs279675; rs1405237; rs13223149; rs279707; rs2215359; rs10233433; rs2268077; rs279679; rs10488107; rs10242443; rs1206380; rs12217; rs10246405; rs10464523; rs35040361; rs34141526; rs1405235; rs279702; rs1060229; rs6952185; rs13244397; rs6962679; rs10230768; rs1638961; rs3069225; rs35554728; rs34474265; rs13232539; rs6948979; rs12530583; rs13241339; rs41281710; rs2191296; rs34361634; rs35606909; rs28764931; rs35504523; rs28867970; rs6975301; rs1526317; rs35879326; rs35726770; rs6944507; rs13236890; rs35084745; rs17144085; rs35291950; rs34978806; rs35318724; rs34956031; rs35432331; rs34360736; rs10246429; rs13241330; rs279705; rs3180765; rs13231643; rs34033806; rs7455978; rs3180764; rs34112213; rs34729256; rs11765420; rs3832518; rs17532418; rs3213701; rs279672; rs6968099; rs34469506; rs17144088; rs34960462; rs34641952; rs28405443; rs12155158; rs279670; rs12113314; rs34852879; rs36059311; rs35704579; rs35361108; rs41281707; rs3213700; rs5887069; rs17532544; rs35006538; rs13231638; rs1138795; rs1065593; rs33947582; rs3202823; rs11379836; rs17348794; rs35382381; rs1061742; rs1138793; rs1206377; rs1206378; rs12532318; rs12674287; rs13232727; rs2268072; rs2268073; rs2270884; rs2300199; rs2300201; rs279689; rs279704; rs4727938; rs758692; rs7800294

# Metabolic_Enzyme_16_General_References:
12853948

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5536

# Metabolic_Enzyme_17_Name:
Branched-chain-amino-acid aminotransferase, cytosolic

# Metabolic_Enzyme_17_Synonyms:
BCAT(c; ECA39 protein

# Metabolic_Enzyme_17_Gene_Name:
BCAT1

# Metabolic_Enzyme_17_Protein_Sequence:
>Branchedchainaminoacid aminotransferase, cytosolic
MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTV
EWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRM
YRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPTK
ALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEAVDN
GCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQ
WGEFKVSERYLTMDDLSTALEGNRVREMFGSGTACVVCPVSDILYKGETIHIPTMENGPK
LASRILSKLTDIQYGREESDWTIVLS

# Metabolic_Enzyme_17_Number_of_Residues:
386

# Metabolic_Enzyme_17_Molecular_Weight:
42953

# Metabolic_Enzyme_17_Theoretical_pI:
4.95

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
Function:  branched-chain-amino-acid transaminase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  branched chain family amino acid metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_17_Specific_Function:
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine

# Metabolic_Enzyme_17_Pathway:
map00280  Valine, leucine and isoleucine degradation;
 map00290  Valine, leucine and isoleucine biosynthesis;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_17_Reaction:
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF01063:Aminotran_4

# Metabolic_Enzyme_17_Signals:
None

# Metabolic_Enzyme_17_Transmembrane_Regions:
None

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 2.6.1.42

# Metabolic_Enzyme_17_GenBank_ID_Protein:
1036780

# Metabolic_Enzyme_17_SwissProt_ID:
BCAT1_HUMAN (P54687)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
BCAT1

# Metabolic_Enzyme_17_Geneatlas_id:
BCAT1

# Metabolic_Enzyme_17_hgnc_id:
HGNC:976

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_17_Gene_Sequence:
>1155 bp
ATGGATTGCAGTAACGGATCGGCAGAGTGTACCGGAGAAGGAGGATCAAAAGAGGTGGTG
GGGACTTTTAAGGCTAAAGACCTAATAGTCACACCAGCTACCATTTTAAAGGAAAAACCA
GACCCCAATAATCTGGTTTTTGGAACTGTGTTCACGGATCATATGCTGACGGTGGAGTGG
TCCTCAGAGTTTGGATGGGAGAAACCTCATATCAAGCCTCTTCAGAACCTGTCATTGCAC
CCTGGCTCATCAGCTTTGCACTATGCAGTGGAATTATTTGAAGGATTGAAGGCATTTCGA
GGAGTAGATAATAAAATTCGACTGTTTCAGCCAAACCTCAACATGGATAGAATGTATCGC
TCTGCTGTGAGGGCAACTCTGCCGGTATTTGACAAAGAAGAGCTCTTAGAGTGTATTCAA
CAGCTTGTGAAATTGGATCAAGAATGGGTCCCATATTCAACATCTGCTAGTCTGTATATT
CGTCCTGCATTCATTGGAACTGAGCCTTCTCTTGGAGTCAAGAAGCCTACCAAAGCCCTG
CTCTTTGTACTCTTGAGCCCAGTGGGACCTTATTTTTCAAGTGGAACCTTTAATCCAGTG
TCCCTGTGGGCCAATCCCAAGTATGTAAGAGCCTGGAAAGGTGGAACTGGGGACTGCAAG
ATGGGAGGGAATTACGGCTCATCTCTTTTTGCCCAATGTGAAGACGTAGATAATGGGTGT
CAGCAGGTCCTGTGGCTCTATGGCAGAGACCATCAGATCACTGAAGTGGGAACTATGAAT
CTTTTTCTTTACTGGATAAATGAAGATGGAGAAGAAGAACTGGCAACTCCTCCACTAGAT
GGCATCATTCTTCCAGGAGTGACAAGGCGGTGCATTCTGGACCTGGCACATCAGTGGGGT
GAATTTAAGGTGTCAGAGAGATACCTCACCATGGATGACTTGACAACAGCCCTGGAGGGG
AACAGAGTGAGAGAGATGTTTAGCTCTGGTACAGCCTGTGTTGTTTGCCCAGTTTCTGAT
ATACTGTACAAAGGCGAGACAATACACATTCCAACTATGGAGAATGGTCCTAAGCTGGCA
AGCCGCATCTTGAGCAAATTAACTGATATCCAGTATGGAAGAGAAGAGAGCGACTGGACA
ATTGTGCTATCCTGA

# Metabolic_Enzyme_17_GenBank_ID_Gene:
U21551

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_17_Locus:
12pter-q12

# Metabolic_Enzyme_17_SNPs:
rs7313020; rs17374285; rs1872644; rs2220269; rs1872645; rs6487421; rs2353483; rs4453321; rs6487420; rs1054277; rs2353481; rs1471842; rs1043851; rs3198082; rs1054281; rs1054279; rs1043881; rs12371993; rs4963801; rs7296995; rs7305794; rs2029986; rs11486; rs2200509; rs12578267; rs6487419; rs2353482; rs2046524; rs3825167; rs11047652; rs7134734; rs11047654; rs12231434; rs10842409; rs11047724; rs17371571; rs7134619; rs7306168; rs7315828; rs7134871; rs1872646; rs2046525; rs1471844; rs976436; rs2291894; rs2173606; rs2062497; rs2242400; rs7954529; rs3759085; rs1813470; rs7310300; rs11613673; rs7297229; rs4963596; rs11047676; rs6487428; rs10842418; rs10842431; rs937503; rs7296211; rs2029985; rs4963820; rs2046526; rs6487431; rs7296881; rs10771144; rs11610069; rs2352745; rs12425320; rs6487436; rs11047684; rs954200; rs3736212; rs2242399; rs7976928; rs7977807; rs4462438; rs6487435; rs7299023; rs7964239; rs12319639; rs954199; rs10466757; rs12424348; rs7968890; rs10505954; rs2133587; rs11047717; rs718567; rs11047686; rs7975904; rs3759086; rs10842413; rs6487434; rs11047679; rs4963822; rs7312749; rs6487429; rs2352746; rs16928083; rs10842414; rs7969149; rs3950612; rs10505952; rs10771142; rs6487437; rs16928141; rs12422599; rs2129236; rs1566406; rs12580682; rs10771138; rs4963810; rs2133588; rs16928207; rs16928163; rs16928145; rs12423866; rs4531567; rs16928217; rs6487433; rs11047685; rs2133582; rs11047716; rs10842429; rs7305924; rs7967945; rs1499805; rs11047709; rs7956863; rs7299760; rs11047692; rs12424211; rs7962203; rs954201; rs4963830; rs11609552; rs2047554; rs10771132; rs10842415; rs11047707; rs7959036; rs2353478; rs10505955; rs11047689; rs1546197; rs10842423; rs4143211; rs16928097; rs11047696; rs4963814; rs11047682; rs7978032; rs10771133; rs11608526; rs12318469; rs4963818; rs10160847; rs12366540; rs16928111; rs1119693; rs1566407; rs2353472; rs10842420; rs6487430; rs10842424; rs17314214; rs1392196; rs4143210; rs924191; rs11047708; rs1546196; rs12320158; rs1497257; rs4963594; rs10743524; rs10842416; rs3736211; rs12579934; rs12321766; rs10771140; rs10842427; rs10842433; rs7960010; rs10128933; rs7313260; rs16928089; rs7972930; rs7298696; rs1391028; rs12302883; rs10771139; rs10771130; rs9804952; rs7303413; rs4963804; rs10842421; rs7978793; rs12227915; rs7973974; rs10842417; rs2047555; rs7970244; rs10505953; rs4963808; rs1392195; rs10771128; rs7138654; rs2201712; rs10771141; rs10771127; rs11047674; rs7961778; rs2306766; rs11835201; rs3759088; rs16928168; rs11047693; rs7965655; rs4522264; rs10842422; rs11047665; rs10161442; rs16928173; rs7966104; rs12321731; rs4963805; rs10771146; rs3926539; rs11047712; rs2062495; rs4603392; rs11047711; rs11047721; rs2883181; rs1471843; rs12427117; rs10743526; rs12296255; rs11615930; rs12422783; rs11047697; rs11047706; rs4963802; rs1105937; rs11833854; rs10771129; rs4963823; rs17313239; rs10771143; rs10771134; rs10466799; rs7136436; rs10743521; rs7969444; rs17315488; rs12579655; rs12172778; rs7138685; rs3759087; rs4406910; rs1875092; rs11047677; rs2133589; rs7967953; rs7955672; rs7398085; rs7484721; rs10047592; rs12318827; rs11615863; rs4963806; rs4963821; rs12322309; rs11830394; rs7976171; rs16928186; rs11047714; rs11047668; rs4459405; rs7966783; rs10743525; rs12229422; rs6487427; rs12817139; rs1075061; rs4246225; rs7953453; rs12230816; rs12322341; rs7969612; rs12320547; rs12818299; rs11047700; rs11047715; rs7138806; rs1077102; rs17342494; rs2353479; rs17372766; rs7961688; rs4963817; rs11047723; rs12372519; rs17373566; rs5012437; rs12423288; rs16928169; rs11047669; rs7955886; rs11047695; rs17375619; rs17316319; rs1075062; rs12427184; rs7299787; rs11830163; rs12371441; rs11610213; rs2291895; rs11047678; rs11047681; rs9989035; rs11047691; rs11047671; rs11047667; rs11047699; rs12319283; rs12228257; rs4031159; rs12230878; rs11613710; rs11613482; rs4963815; rs7298907; rs7307610; rs11047702; rs2353473; rs10047590; rs10771145; rs12316589; rs17315467; rs1846581; rs1119692; rs2352747; rs10842434; rs11047660; rs7961152; rs11047657; rs10743527; rs7969649; rs1875091; rs4963593; rs7978338; rs4143212; rs4963811; rs16928171; rs11612450; rs12313518; rs2220270; rs2173605; rs11047722; rs4296116; rs10842430; rs16928149; rs7970200; rs12296315; rs10219671; rs2255206; rs2353484; rs2353485; rs3794263; rs7959326; rs10842436; rs1048368; rs2353486; rs10734736; rs7970725; rs1463625; rs1497255; rs7955676; rs1057204; rs35600421; rs17374606; rs4423275; rs35585041; rs11047651; rs35186964; rs12582215; rs15643; rs12366411; rs11433688; rs35804569; rs34453620; rs36085546; rs33947278; rs5797102; rs11047650; rs11384696; rs12301168; rs666928; rs12831930; rs35951011; rs36070747; rs12828108; rs10688526; rs12296452; rs34174229; rs34780357; rs4963819; rs34032061; rs34504461; rs34414606; rs5797104; rs34876959; rs5797105; rs34153775; rs12316475; rs7967922; rs665254; rs34501736; rs12817209; rs35203857; rs12422829; rs12296646; rs866358; rs12301149; rs11047661; rs35989805; rs12820872; rs34044660; rs35455721; rs34556925; rs1874598; rs7485585; rs10585254; rs35693234; rs35550560; rs11370314; rs12228347; rs5797108; rs11047687; rs11415752; rs10466800; rs11047659; rs35850216; rs17314570; rs625604; rs2270771; rs11047683; rs34237642; rs9804807; rs4963809; rs12817395; rs10585144; rs12310054; rs34835991; rs11616042; rs12300357; rs35406045; rs12319312; rs12229613; rs2649778; rs2133584; rs2291896; rs34227038; rs10842432; rs10595838; rs36124065; rs35488171; rs35203074; rs35427447; rs35151527; rs11608755; rs2133585; rs12823840; rs4031157; rs3950611; rs11615196; rs12818315; rs3044337; rs34802588; rs12816139; rs12816228; rs34677835; rs34476055; rs35060237; rs34165520; rs34902696; rs35984920; rs34151647; rs34717106; rs12310217; rs12818883; rs35033368; rs4963595; rs5797106; rs11047719; rs34329602; rs2645897; rs11310819; rs35929602; rs34808872; rs34508149; rs11047670; rs12825177; rs12827517; rs7968043; rs7980970; rs1693356; rs12810541; rs35423225; rs33963375; rs4432099; rs11047655; rs35331816; rs11047710; rs2645908; rs2649777; rs7309420; rs860869; rs10553165; rs28459289; rs12312774; rs11047666; rs35669075; rs12424534; rs11616041; rs35606332; rs17315509; rs12810226; rs11612132; rs35593379; rs2062496; rs10743522; rs11614032; rs7306822; rs35643898; rs11047703; rs35195819; rs2270772; rs2133583; rs11047720; rs35270432; rs34776365; rs11394415; rs28678340; rs10541735; rs35646001; rs840797; rs4963825; rs10643112; rs4963824; rs7970415; rs11047718; rs11047656; rs4963826; rs11327300; rs34707102; rs2133586; rs2883180; rs34370749; rs11440596; rs34430745; rs11392086; rs11047701; rs12319952; rs34143445; rs5797107; rs11047672; rs11047688; rs7296005; rs34780543; rs12227952; rs34331143; rs10561433; rs11318750; rs12230723; rs11047680; rs2645904; rs11345548; rs35939998; rs11614469; rs675368; rs4963807; rs596765; rs35566363; rs11442641; rs34858948; rs12320957; rs34377944; rs12313801; rs35181244; rs4963812; rs10616253; rs36137247; rs7972955; rs2220271; rs11047662; rs35801229; rs11047694; rs10697494; rs12817355; rs2645907; rs12581783; rs4031158; rs35477401; rs4031153; rs667888; rs1622629; rs4963813; rs2649776; rs34705263; rs35978550; rs11047704; rs34761531; rs7975240; rs3044287; rs12818310; rs12818301; rs7308285; rs7953787; rs10546505; rs36067986; rs35477889; rs7136511; rs34706565; rs34990218; rs16928147; rs34860589; rs12229575; rs36036274; rs11047705; rs35440053; rs11320109; rs866357; rs34549035; rs11047673; rs11047663; rs4400889; rs7131753; rs12367115; rs28491628; rs11047713; rs10548732; rs12830129; rs1075063; rs12582334; rs7968607; rs9668094; rs35277052; rs12821845; rs12299696; rs3830305; rs12371444; rs12831941; rs10589289; rs11369972; rs34420618; rs11047690; rs11831592; rs4257068; rs35063724; rs11047664; rs587649; rs10743523; rs10714031; rs11047698; rs668707; rs36035411; rs34285635; rs1497256; rs593165; rs9668028; rs35543389; rs10662028; rs5797103; rs35693867; rs3044290; rs9988971; rs34676819; rs10842435; rs35336188; rs1872643; rs10219508; rs10219610; rs1032589; rs10743520; rs10771123; rs10771124; rs10771125; rs10842408; rs10842437; rs10842439; rs11047645; rs11047647; rs11047648; rs11047726; rs11829886; rs1213075; rs12301529; rs12368831; rs12582944; rs12819423; rs1471841; rs16928015; rs17316445; rs17322922; rs17322957; rs34277634; rs34589683; rs35085353; rs4255624; rs4406909; rs4429151; rs4569089; rs4963795; rs4963796; rs4963797; rs4963800; rs619755; rs6487417; rs7299477; rs7307399; rs7961311; rs7961506; rs7964847; rs7979563; rs7979723

# Metabolic_Enzyme_17_General_References:
8692959

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5633

# Metabolic_Enzyme_18_Name:
Alanine--glyoxylate aminotransferase 2, mitochondrial precursor

# Metabolic_Enzyme_18_Synonyms:
(R-3-amino-2-methylpropionate--pyruvate transaminase; AGT 2; Beta-alanine-pyruvate aminotransferase; Beta- ALAAT II; D-AIBAT

# Metabolic_Enzyme_18_Gene_Name:
AGXT2

# Metabolic_Enzyme_18_Protein_Sequence:
>Alanineglyoxylate aminotransferase 2, mitochondrial precursor
MTLIWRHLLRPLCLVTSAPRILEMHPFLSLGTSRTSVTKLSLHTKPRMPPCDFMPERYQS
LGYNRVLEIHKEHLSPVVTAYFQKPLLLHQGHMEWLFDAEGSRYLDFFSGIVTVSVGHCH
PKVNAVAQKQLGRLWHTSTVFFHPPMHEYAEKLAALLPEPLKVIFLVNSGSEANELAMLM
ARAHSNNIDIISFRGAYHGCSPYTLGLTNVGTYKMELPGGTGCQPTMCPDVFRGPWGGSH
CRDSPVQTIRKCSCAPDCCQAKDQYIEQFKDTLSTSVAKSIAGFFAEPIQGVNGVVQYPK
GFLKEAFELVRARGGVCIADEVQTGFGRLGSHFWGFQTHDVLPDIVTMAKGIGNGFPMAA
VITTPEIAKSLAKCLQHFNTFGGNPMACAIGSAVLEVIKEENLQENSQEVGTYMLLKFAK
LRDEFEIVGDVRGKGLMIGIEMVQDKISCRPLPREEVNQIHEDCKHMGLLVGRGSIFSQT
FRIAPSMCITKPEVDFAVEVFRSALTQHMERRAK

# Metabolic_Enzyme_18_Number_of_Residues:
514

# Metabolic_Enzyme_18_Molecular_Weight:
57157

# Metabolic_Enzyme_18_Theoretical_pI:
7.91

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_18_Specific_Function:
L-alanine + glyoxylate = pyruvate + glycine

# Metabolic_Enzyme_18_Pathway:
map00252  Alanine and aspartate metabolism;
 map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_18_Reaction:
L-alanine + glyoxylate = pyruvate + glycine

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF00202:Aminotran_3

# Metabolic_Enzyme_18_Signals:
1-24

# Metabolic_Enzyme_18_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 2.6.1.44;EC 2.6.1.40

# Metabolic_Enzyme_18_GenBank_ID_Protein:
12406973

# Metabolic_Enzyme_18_SwissProt_ID:
AGT2_HUMAN (Q9BYV1)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
AGXT2

# Metabolic_Enzyme_18_Geneatlas_id:
AGXT2

# Metabolic_Enzyme_18_hgnc_id:
HGNC:14412

# Metabolic_Enzyme_18_PDB_ID:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Mitochondrion (Potential)

# Metabolic_Enzyme_18_Gene_Sequence:
>1545 bp
ATGACTCTAATCTGGAGACATTTGCTGAGACCCTTGTGCCTGGTCACTTCCGCTCCCAGG
ATCCTTGAGATGCATCCTTTCCTGAGCCTAGGTACTTCCCGGACATCAGTAACCAAGCTC
AGTCTTCATACAAAGCCCAGAATGCCTCCATGTGACTTCATGCCTGAAAGATACCAGTCC
CTTGGCTACAACCGTGTCCTGGAAATCCACAAGGAACATCTTTCTCCTGTGGTGACGGCA
TATTTCCAGAAACCCCTGCTGCTCCACCAGGGGCACATGGAGTGGCTCTTTGATGCTGAA
GGAAGCAGATACCTGGATTTCTTTTCCGGGATTGTTACTGTCAGTGTTGGCCATTGCCAC
CCAAAGGTGAATGCAGTGGCACAAAAGCAGCTCGGCCGCCTGTGGCATACAAGCACCGTC
TTCTTCCACCCTCCAATGCATGAATATGCAGAGAAGCTTGCCGCACTTCTTCCTGAGCCT
CTTAAGGTCATTTTCTTGGTGAACAGTGGCTCAGAAGCCAATGAGCTGGCCATGCTGATG
GCCAGGGCGCACTCAAACAACATAGACATCATTTCTTTCAGAGGAGCCTACCATGGATGC
AGTCCTTACACACTTGGCTTGACAAACGTAGGGACCTACAAGATGGAACTCCCTGGTGGG
ACAGGTTGCCAACCAACAATGTGTCCAGATGTTTTTCGTGGCCCTTGGGGAGGAAGCCAC
TGTCGAGATTCTCCAGTGCAAACAATCAGGAAGTGCAGCTGTGCACCAGACTGCTGCCAA
GCTAAAGATCAGTATATTGAGCAATTCAAAGATACGCTGAGCACATCTGTGGCCAAGTCA
ATTGCTGGATTTTTCGCAGAACCTATTCAAGGTGTGAATGGAGTTGTCCAGTACCCAAAG
GGGTTTCTAAAGGAAGCCTTTGAGCTGGTGCGAGCAAGGGGAGGCGTGTGCATTGCAGAT
GAAGTGCAGACAGGATTTGGAAGGTTGGGCTCTCACTTCTGGGGCTTCCAAACCCACGAT
GTCCTGCCTGACATTGTCACCATGGCTAAAGGGATTGGGAATGGCTTTCCCATGGCAGCA
GTCATAACCACTCCAGAGATTGCCAAATCTTTGGCGAAATGCCTGCAGCACTTCAACACC
TTTGGAGGGAACCCCATGGCCTGTGCCATTGGATCTGCTGTGCTTGAGGTGATTAAAGAA
GAAAATCTACAGGAAAACAGTCAAGAAGTTGGGACCTACATGTTACTAAAGTTTGCTAAG
CTGCGGGATGAATTTGAAATTGTTGGAGACGTCCGAGGCAAAGGTCTCATGATAGGCATA
GAAATGGTGCAGGATAAGATAAGCTGTCGGCCTCTTCCCCGTGAAGAAGTAAATCAGATC
CATGAGGACTGCAAGCACATGGGACTCCTCGTTGGCAGAGGCAGCATTTTTTCTCAGACA
TTTCGCATTGCGCCCTCAATGTGCATCACTAAACCAGAAGTTGATTTTGCAGTAGAAGTA
TTTCGTTCTGCCTTAACCCAACACATGGAAAGAAGAGCTAAGTAA

# Metabolic_Enzyme_18_GenBank_ID_Gene:
AJ292204

# Metabolic_Enzyme_18_Chromosome_Location:
Not Available

# Metabolic_Enzyme_18_Locus:
Not Available

# Metabolic_Enzyme_18_SNPs:
Not Available

# Metabolic_Enzyme_18_General_References:
Not Available

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5388

# Metabolic_Enzyme_19_Name:
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_19_Synonyms:
P5C dehydrogenase; Aldehyde dehydrogenase 4A1

# Metabolic_Enzyme_19_Gene_Name:
ALDH4A1

# Metabolic_Enzyme_19_Protein_Sequence:
>Delta1pyrroline5carboxylate dehydrogenase, mitochondrial precursor
MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGR
MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP
IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL
EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML
ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ
NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL
WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK
CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG
AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR
WTSPQVIKETHKPLGDWSYAYMQ

# Metabolic_Enzyme_19_Number_of_Residues:
563

# Metabolic_Enzyme_19_Molecular_Weight:
61720

# Metabolic_Enzyme_19_Theoretical_pI:
8.20

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
Function:  1-pyrroline-5-carboxylate dehydrogenase activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  proline metabolism
Process:  proline biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  membrane-enclosed lumen
Component:  organelle lumen
Component:  mitochondrial lumen
Component:  mitochondrial matrix

# Metabolic_Enzyme_19_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_19_Specific_Function:
Irreversible conversion of delta-1-pyrroline-5- carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes

# Metabolic_Enzyme_19_Pathway:
map00251  Glutamate metabolism;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_19_Reaction:
1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H+

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_19_Signals:
1-19

# Metabolic_Enzyme_19_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 1.5.1.12

# Metabolic_Enzyme_19_GenBank_ID_Protein:
1353250

# Metabolic_Enzyme_19_SwissProt_ID:
AL4A1_HUMAN (P30038)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
ALDH4A1

# Metabolic_Enzyme_19_Geneatlas_id:
ALDH4A1

# Metabolic_Enzyme_19_hgnc_id:
HGNC:406

# Metabolic_Enzyme_19_PDB_ID:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_19_Gene_Sequence:
>1692 bp
ATGCTGCTGCCGGCGCCCGCGCTCCGCCGCGCCCTGCTGTCCCGCCCCTGGACCGGGGCC
GGCCTGCGGTGGAAGCACACCTCCTCCCTGAAGGTGGCCAACGAGCCCGTCTTAGCCTTC
ACGCAGGGCAGCCCTGAGCGAGATGCCCTGCAAAAGGCCTTGAAGGACCTGAAGGGCCGG
ATGGAAGCCATCCCATGCGTGATGGGGGATGAGGAGGTGTGGACGTCGGACGTGCAGTAC
CAAGTGTCGCCTTTTAACCATGGACATAAGGTGGCCAAGTTCTGTTATGCAGACAAGAGC
CTGCTCAACAAAGCCATTGAGGCTGCCCTGGCTGCCCGGAAAGAGTGGGACCTGAAGCCT
ATTGCAGACCGGGCCCAGATCTTCCTGAAGGCGGCAGACATGCTGAGTGGGCCGCGCAGG
GCTGAGATCCTCGCCAAGACCATGGTGGGACAGGGTAAGACCGTGATCCAAGCGGAGATT
GACGCTGCAGCGGAACTCATCGACTTCTTCCGGTTCAATGCCAAGTATGCGGTGGAGCTG
GAGGGGCAGCAGCCCATCAGCGTGCCCCCGAGCACCAACAGCACGGTGTACCGGGGTCTG
GAGGGCTTCGTGGCGGCCATCTCGCCCTTTAACTTCACTGCAATCGGCGGCAACCTGGCG
GGGGCACCGGCCCTGATGGGCAACGTGGTCCTATGGAAGCCCAGTGACACTGCCATGCTG
GCCAGCTATGCTGTCTACCGCATCCTTCGGGAGGCTGGCCTGCCCCCCAACATCATCCAG
TTTGTGCCAGCTGATGGGCCCCTATTTGGGGACACTGTCACCAGCTCAGAGCACCTCTGT
GGCATCAACTTCACAGGCAGTGTGCCCACCTTCAAACACCTGTGGAAGCAGGTGGCCCAG
AACCTGGACCGGTTCCACACCTTCCCACGCCTGGCTGGAGAGTGCGGCGGAAAGAACTTC
CACTTCGTGCACCGCTCGGCCGACGTGGAGAGCGTGGTGAGCGGGACCCTCCGCTCAGCC
TTCGAGTACGGTGGCCAGAAGTGTTCCGCCTGCTCGCGTCTCTACGTGCCGCACTCGCTG
TGGCCGCAGATCAAAGGGCGGCTGCTGGAGGAGCACAGTCGGATCAAAGTGGGCGACCCT
GCAGAGGATTTTGGGACCTTCTTCTCTGCAGTGATTGATGCCAAGTCCTTTGCCCGTATC
AAGAAGTGGCTGGAGCACGCGCGCTCCTCGCCCAGCCTCACCATCCTGGCTGGGGGCAAG
TGTGATGACTCCGTGGGCTACTTTGTGGAGCCCTGCATCGTGGAGAGCAAGGACCCTCAG
GAGCCCATCATGAAGGAGGAGATCTTCGGGCCTGTACTGTCTGTGTACGTCTACCCGGAC
GACAAGTACAAGGAGACGCTGCAGCTGGTTGACAGCACCACCAGCTATGGCCTCACGGGG
GCAGTGTTCTCCCAGGATAAGGACGTCGTGCAGGAGGCCACAAAGGTGCTGAGGAATGCT
GCCGGCAACTTCTACATCAACGACAAGTCCACTGGCTCGATAGTGGGCCAGCAGCCCTTT
GGGGGGGCCCGAGCCTCTGGAACCAATGACAAGCCAGGGGGCCCACACTACATCCTGCGC
TGGACGTCGCCGCAGGTCATCAAGGAGACACATAAGCCCCTGGGGGACTGGAGCTACGCG
TACATGCAGTGA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
U24267

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_19_Locus:
1p36

# Metabolic_Enzyme_19_SNPs:
rs6695033; rs2230709; rs7550938; rs2230707; rs2230708; rs2230706; rs2230705; rs3202002; rs11740; rs1138267; rs1140477; rs9117; rs1138333; rs14311; rs7366541; rs7419135; rs1138328; rs1138269; rs7554974; rs4912075; rs6664725; rs6426813; rs7365362; rs7555171; rs16862341; rs6426814; rs6426802; rs9426721; rs1009971; rs16862344; rs7517650; rs9426640; rs9426794; rs28715641; rs17492518; rs9426726; rs6665917; rs4911985; rs7517638; rs7537155; rs9426642; rs28441017; rs6695228; rs6664619; rs6661040; rs6426611; rs7364434; rs3935824; rs7416425; rs2295227; rs41306567; rs41273175; rs41310410; rs1138343; rs1138292; rs2230710; rs11484737; rs9426797; rs34458848; rs9426679; rs41273171; rs34467064; rs11311839; rs1802783; rs1138339; rs2230712; rs28665699; rs35708241; rs35285457; rs34454742; rs11487496; rs28673930; rs28663527; rs28755825; rs28605607; rs28523548; rs28451394; rs9426752; rs35657817; rs28543677; rs9426796; rs28498975; rs34445898; rs35939464; rs9426641; rs28497538; rs28666920; rs7366122; rs7364713; rs34319466; rs28680194; rs35434984; rs9426639; rs34426697; rs1009972; rs28515071; rs28528764; rs28481840; rs28656793; rs7529296; rs28526299; rs9426745; rs28758607; rs28405710; rs941495; rs3028639; rs35359971; rs9426646; rs6682091; rs28498083; rs34118509; rs28482373; rs3018811; rs7365410; rs28434041; rs11320823; rs28739297; rs9426792; rs9426724; rs10524811; rs7518631; rs4559535; rs11487490; rs28409312; rs35565438; rs2983103; rs28493067; rs34108830; rs7365978; rs28566028; rs11353740; rs9426795; rs28501481; rs41302007; rs3018810; rs28523560; rs41273173; rs9426793; rs28756052; rs11484743; rs34527859; rs4592275; rs9426727; rs6666036; rs28529092; rs12120787; rs11435364; rs28674731; rs28582076; rs28508407; rs28403282; rs28700162; rs36101161; rs7534676; rs6668941; rs28582764; rs28373885; rs7550822; rs28594104; rs9426678; rs9426648; rs35163726; rs9426638; rs28479140; rs9426725; rs28709274; rs35960030; rs7551139; rs28602267; rs28482942; rs34857453; rs35255325; rs35939548; rs28676571; rs28657562; rs9426723; rs9426718; rs34867193; rs34066485; rs9426645; rs2983105; rs9699485; rs9426681; rs2983104; rs4912044; rs34374377; rs35141036; rs9659393; rs9426680; rs11488729; rs16862353; rs28561925; rs41273169; rs41273177; rs11484747; rs9700261; rs12729853; rs12745794; rs16862355; rs16862359; rs2024724; rs28584327; rs28624425; rs28652778; rs34457793; rs34684373; rs35217608; rs3811400; rs3811401; rs3828046; rs6673711; rs9662598; rs9725877; rs9727742; rs9727752

# Metabolic_Enzyme_19_General_References:
8621661; 1395511; 1286669; 9700195

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
5953

# Metabolic_Enzyme_20_Name:
Glutaminase kidney isoform, mitochondrial precursor

# Metabolic_Enzyme_20_Synonyms:
GLS; L-glutamine amidohydrolase; K-glutaminase

# Metabolic_Enzyme_20_Gene_Name:
GLS

# Metabolic_Enzyme_20_Protein_Sequence:
>Glutaminase kidney isoform, mitochondrial precursor
MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVE
VVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQT
VHKNLDGLL

# Metabolic_Enzyme_20_Number_of_Residues:
669

# Metabolic_Enzyme_20_Molecular_Weight:
73462

# Metabolic_Enzyme_20_Theoretical_pI:
7.82

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Function:  glutaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_20_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_20_Specific_Function:
Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine

# Metabolic_Enzyme_20_Pathway:
map00251  Glutamate metabolism;
 map00471  D-Glutamine and D-glutamate metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_20_Reaction:
L-glutamine + H2O = L-glutamate + NH3

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00023:Ank;
PF04960:Glutaminase

# Metabolic_Enzyme_20_Signals:
1-23

# Metabolic_Enzyme_20_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 3.5.1.2

# Metabolic_Enzyme_20_GenBank_ID_Protein:
5690372

# Metabolic_Enzyme_20_SwissProt_ID:
GLSK_HUMAN (O94925)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
GLS

# Metabolic_Enzyme_20_Geneatlas_id:
GLS

# Metabolic_Enzyme_20_hgnc_id:
HGNC:4331

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_20_Gene_Sequence:
>1797 bp
ATGATGCGGCTGCGAGGCTCGGGGATGCTGCGGGACCTGCTCCTGCGGTCGCCCGCCGGC
GTGAGCGNGACTCTGCGGCGGGCACAGCCCTTGGTCACCCTGTGCCGGCGTCCCCGAGGC
GGGGGACGGCCGGCCGCGGGCCCGGCTGCCGCCGCGCGACTCCACCCGTGGTGGGGCGGG
GGCGGCTGGCCGGCGGAGCCCCTCGCGCGGGGCCTGTCCAGCTCTCCTTCGGAGATCTTG
CAGGAGCTGGGCAAGGGGAGCACGCATCCCCAGCCCGGGGTGTCGCCACCCGCTGCCCCG
GCGGCGCCCGGCCCCAAGGACGGCCCCGGGGAGACGGACGCGTTTGGCAACAGCGAGGGC
AAAGAGCTGGTGGCCTCAGGTGAAAACAAAATAAAACAGGGTCTGTTACCTAGCTTGGAA
GATTTGCTGTTCTATACAATTGCTGAAGGACAAGAGAAAATACCTGTTCATAAATTTATT
ACAGCACTCAAATCTACAGGATTGCGAACGTCTGATCCCAGGTTGAAAGAGTGTATGGAT
ATGTTAAGATTAACTCTTCAAACAACATCAGATGGTGTCATGCTAGACAAAGATCTTTTT
AAAAAATGTGTTCAGAGCAACATTGTTTTGTTGACACAAGCATTTAGAAGAAAGTTTGTG
ATTCCTGACTTTATGTCTTTTACCTCACACATTGATGAGTTATATGAAAGTGCTAAAAAG
CAGTCTGGAGGAAAGGTTGCAGATTATATTCCTCAACTGGCCAAATTCAGTCCCGATTTG
TGGGGTGTGTCTGTTTGTACAGCAGATGGACAGAGGCATTCTACTGGAGATACCAAAGTT
CCCTTCTGTCTTCAGTCCTGTGTAAAACCTTTGAAATATGCCATTGCTGTTAATGATCTT
GGAACTGAATATGTGCATCGATATGTTGGAAAAGAGCCGAGTGGACTAAGATTCAACAAA
CTATTTTTGAATGAAGATGATAAACCACATAATCCTATGGTAAATGCTGGAGCAATTGTT
GTGACTTCACTAATAAAGCAAGGAGTAAATAATGCTGAAAAATTTGACTATGTCATGCAG
TTTTTGAATAAGATGGCTGGTAATGAATATGTTGGATTCAGTAATGCAACGTTTCAGTCT
GAAAGAGAAAGTGGAGATCGAAATTTTGCAATAGGATATTACTTAAAAGAAAAGAAGTGT
TTTCCAGAAGGCACAGACATGGTTGGTATATTAGACTTCTACTTCCAGCTGTGCTCCATT
GAAGTGACTTGTGAATCAGCCAGTGTGATGGCTGCGACACTGGCTAATGGTGGTTTCTGC
CCAATTACTGGTGAAAGAGTACTGAGCCCTGAAGCAGTTCGAAATACATTGAGTTTGATG
CATTCCTGTGGCATGTATGACTTCTCAGGGCAGTTTGCTTTCCATGTTGGTCTTCCTGCA
AAATCTGGAGTTGCTGGGGGCATTCTTTTAGTTGTCCCCAATGTTATGGGTATGATGTGC
TGGTCTCCTCCTCTGGATAAGATGGGCAACAGTGTTAAGGGAATTCACTTTTGTCACGAT
CTTGTTTCTCTGTGTAATTTCCATAACTATGATAATTTGAGACACTTTGCAAAAAAACTT
GATCCTCGAAGAGAAGGTGGTGATCAAAGGCATTCCTTTGGACCATTGGACTATGAAAGT
CTCCAACAAGAACTTGCTTTAAAAGAGACAGTATGGAAAAAAGTGTCACCTGAGTCAAAT
GAGGACATCTCTACAACTGTAGTATATAGAATGGAAAGTCTGGGAGAGAAAAGCTAA

# Metabolic_Enzyme_20_GenBank_ID_Gene:
AF158555

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_20_Locus:
2q32-q34

# Metabolic_Enzyme_20_SNPs:
rs3732211; rs1168; rs1546646; rs3088307; rs1546647; rs10437; rs1546648; rs13035504; rs16833113; rs2883582; rs1921907; rs883844; rs1921914; rs867637; rs2203715; rs984610; rs11691127; rs1921915; rs4853454; rs1921912; rs3771316; rs4853531; rs6758866; rs6434429; rs6434430; rs2355570; rs4853530; rs11692579; rs1517356; rs4853528; rs6743496; rs932170; rs1921913; rs3771311; rs17815942; rs1517355; rs16833049; rs3771308; rs3771310; rs12998878; rs3771304; rs16833031; rs17748089; rs10931476; rs11683679; rs1607187; rs11693788; rs12987113; rs3771313; rs12185688; rs13001395; rs7564529; rs4597558; rs1517354; rs6713444; rs6721631; rs13384728; rs10497710; rs3732212; rs2355571; rs2883713; rs16833050; rs2108818; rs11894259; rs11681912; rs16833073; rs16833053; rs16833056; rs1033249; rs13000464; rs16833092; rs16833069; rs3087950; rs13414554; rs16833067; rs12992618; rs11674731; rs11677838; rs3771307; rs16833042; rs6712504; rs11688967; rs11889157; rs3771314; rs4853529; rs16833040; rs11675981; rs16833020; rs12467368; rs1921909; rs3755313; rs16833035; rs35890674; rs1801893; rs17853842; rs3199238; rs3207596; rs1136115; rs1058590; rs1136112; rs1136107; rs1136111; rs1058592; rs1801892; rs1058589; rs3207595; rs3199237; rs3207597; rs1136114; rs1058591; rs1136113; rs3836129; rs34962483; rs28930678; rs11268964; rs11272113; rs34913321; rs34693346; rs10645506; rs34009071; rs34646339; rs13024969; rs35753740; rs12620987; rs33957014; rs34322022; rs11386437; rs5837213; rs34719838; rs11306120; rs33998570; rs34470725; rs11547780; rs36064959; rs11547781; rs34687743; rs3217036; rs6751852; rs11886120; rs34219109; rs34101296; rs10198061; rs6713807; rs7586514; rs11368612; rs5837211; rs35376983; rs11299475; rs34298947; rs35621182; rs34999321; rs1045208; rs34287390; rs34660567; rs10529560; rs35016708; rs6729740; rs34844301; rs3771309; rs34841385; rs34809982; rs3821234; rs13399044; rs34359726; rs35122426; rs7602927; rs4511752; rs4853452; rs10532100; rs35048130; rs35360323; rs36013374; rs10623498; rs34798536; rs3215259; rs34801561; rs36074537; rs33972110; rs36025643; rs2292790; rs35915280; rs34900059; rs10590551; rs35272604; rs2355572; rs36008676; rs35542564; rs34419675; rs13414648; rs35034516; rs34717146; rs11363248; rs35910874; rs5837212; rs10716407; rs13391964; rs35968676; rs35712414; rs11377483; rs2178605; rs3771312; rs34752857; rs33958764; rs13012566; rs2292792; rs34312179; rs13017410; rs34466013; rs3039186; rs11370315; rs3036651; rs41270235; rs34914533; rs35453613; rs12990256; rs4853453; rs10221634; rs3771303; rs35957111; rs34053475; rs35745438; rs34321717; rs35868744; rs34901974; rs11547782; rs13414269; rs10665259; rs34793584; rs13000734; rs2292791; rs7558585; rs17816440; rs16833121; rs28362510; rs12997127; rs35314646; rs11305; rs11687659; rs11690599; rs11885168; rs11894425; rs11899865; rs12468579; rs12693589; rs12987796; rs13395505; rs1400657; rs16824035; rs16833123; rs16833126; rs17748980; rs1914407; rs1914408; rs2066793; rs2066803; rs2204859; rs35364817; rs3771300; rs4853526; rs4853533; rs6718902; rs6734110; rs7575823; rs9789700

# Metabolic_Enzyme_20_General_References:
11015561; 10048485; 10719215

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
6006

# Metabolic_Enzyme_21_Name:
Gamma-glutamyltransferase 4 precursor

# Metabolic_Enzyme_21_Synonyms:
Gamma- glutamyltranspeptidase 4; Gamma-glutamyltransferase-like 3; Gamma- glutamyltransferase-like 5[Contains: Gamma-glutamyltransferase 4 heavy chain; Gamma-glutamyltransferase 4 light chain]

# Metabolic_Enzyme_21_Gene_Name:
GGTL3

# Metabolic_Enzyme_21_Protein_Sequence:
>Gammaglutamyltransferase 4 precursor
MAAENEASQESALGAYSPVDYMSITSFPRLPEDEPAPAAPLRGRKDEDAFLGDPDTDPDS
FLKSARLQRL
PSSSSEMGSQDGSPLRETRKDPFSAAAAECSCRQDGLTVIVTACLTFAT
GVTVALVMQIYFGDPQIFQQG
AVVTDAARCTSLGIEVLSKQGSSVDAAVAAALCLGIVA
PHSSGLGGGGVMLVHDIRRNESHLIDFRESAP
GALREETLQRSWETKVGTLPGLLVGVP
GMVKGLHEAHQLYGRLPWSQVLAFAAAVAQDGFNVTHDLARAL
AEQLPPNMSERFRETF
LPSGRPPLPGSLLHRPDLAEVLDVLGTSGPAAFYAGGNLTLEMVAEAQHAGGVI
TEEDF
SNYSALVEKPVCGVYRGHLVLSPPPPHTGPALISALNILEGFNLTSLVSREQALHWVAET
LKIAL
ALASRLGDPVYDSTITESMDDMLSKVEAAYLRGHINDSQAAPAPLLPVYELDGA
PTAAQVLIMGPDDFIV
AMVSSLNQPFGSGLITPSGILLNSQMLDFSWPNRTANHSAPSL
ENSVQPGKRPLSFLLPTVVRPAEGLCG
TYLALGANGAARGLSGLTQVLLNVLTLNRNLS
DSLARGRLHPDLQSNLLQVDSEFTEEEIEFLEARGHHV
EKVDVLSWVHGSRRTNNFIIA
VKDPRSPDAAGATIL

# Metabolic_Enzyme_21_Number_of_Residues:
666

# Metabolic_Enzyme_21_Molecular_Weight:
70838

# Metabolic_Enzyme_21_Theoretical_pI:
4.73

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring amino-acyl groups
Function:  gamma-glutamyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_21_Specific_Function:
Cleaves glutathione conjugates

# Metabolic_Enzyme_21_Pathway:
map00430  Taurine and hypotaurine metabolism;
 map00450  Selenoamino acid metabolism;
 map00460  Cyanoamino acid metabolism;
 map00480  Glutathione metabolism;
 map00590  Prostaglandin and leukotriene metabolism

# Metabolic_Enzyme_21_Reaction:
(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF01019:G_glu_transpept

# Metabolic_Enzyme_21_Signals:
None

# Metabolic_Enzyme_21_Transmembrane_Regions:
107-127

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 2.3.2.2

# Metabolic_Enzyme_21_GenBank_ID_Protein:
28192538

# Metabolic_Enzyme_21_SwissProt_ID:
GGT4_HUMAN (Q9UJ14)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
GGTL3

# Metabolic_Enzyme_21_Geneatlas_id:
GGTL3

# Metabolic_Enzyme_21_hgnc_id:
HGNC:4259

# Metabolic_Enzyme_21_PDB_ID:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_21_Gene_Sequence:
>756 bp

ATGGCGGCGGAGAAGGAGGCCAGCCAGGAGAGCGCCCTGGGCGCCTACTCGCCAGTGGA
CTACATGAGCA
TCACCAGCTTCCCGCGGCTGCCCGAGGACGAGCCGGCGCCCGCGGCCC
CGCTGAGGGGCCGCAAGGACGA
GGACGCCTTTCTGGGAGACCCCGACACCGACCCGGAC
TCCTTCCTGAAGTCTGCACGGCTGCAGCGGCTG
CCATCGTCGTCGTCGGAGATGGGCAG
CCAAGACGGGTCGCCGCTACGCGAGACGCGCAAAGACCCGTTCT
CCGCCGCAGCGGCCG
AGTGCTCCTGCCGCCAGGATGGGCTCACGGTCATCGTCACGGCCTGTCTCACCTT
CGCT
ACCGGTGTCACCGTGGCGCTGGTCATGCAGATCTACTTCGGGGACCCCCAGATCTTCCAG
CAGGGT
GCCGTGGTGACCGATGCTGCCCGCTGCACTTCACTGGGCATCGAGGTGCTCAG
TAAACAGGGATCTTCTG
TGGACGCAGCGGTGGCAGCAGCCTTGTGTTTGGGTATCGTGG
CTCCACACAGTTCTGGCCTGGGCGGTGG
GGGCGTGATGCTGGTACATGACATCCGACGA
AATGAGAGCCACCTAATTGATTTCCGGGAGTCCGCACCA
GGGGCCCTCAGGGAAGAGAC
CCTGCAAAGATCCTGGGAGACCAAGGTGGGGACCCTGGTGAGAAGAGAGA
GTTCAGGGG
AGTCTCTCTTCATTGCCCTTCTGCTAACCCAAGCATTAATTTGCTAA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
AY138815

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_21_Locus:
20q11.22

# Metabolic_Enzyme_21_SNPs:
rs11546155; rs3746452; rs2076668; rs6088624; rs8120670; rs17092148; rs1984588; rs6120742; rs11699070; rs6119535; rs6119534; rs6119536; rs6120748; rs7263157; rs17122844; rs6120747; rs7354108; rs11697978; rs11698977; rs761481; rs7273470; rs11696546; rs17092149; rs6087639; rs6120746; rs11698996; rs2064453; rs34687214; rs6060095; rs35006054; rs6060078; rs6060079; rs7266944; rs11546156; rs6060080; rs10666634; rs10611859; rs6060082; rs6060081; rs6060077; rs34381589; rs35511575; rs10527077; rs6058126; rs8183445; rs6058127; rs6120743; rs6060084; rs6060096; rs6060097; rs34384459; rs6088627; rs41290902; rs34124885; rs35181666; rs6060090; rs11476486; rs34277320; rs33912843; rs6060098; rs41290904; rs6058129; rs34961294; rs11907458; rs34086165; rs11907128; rs6058128; rs6060099; rs6088633; rs6087640; rs5841184; rs6058125; rs8120847; rs6058130; rs6060083; rs6060103; rs6141519; rs11472270; rs35393655; rs11387013; rs11699132; rs6088629; rs7265109; rs6088628; rs12151936; rs6120744; rs6142253; rs34178465; rs34930184; rs6058124; rs6058132; rs6088631; rs11357916; rs6088632; rs6060085; rs6060092; rs6088625; rs6060088; rs6060091; rs6060102; rs6088626; rs6119531; rs36084138; rs1013677; rs12625149; rs2295095; rs2295096; rs6060072; rs6060073; rs6060074; rs6087641; rs6088635; rs6088638; rs6119540; rs7269682

# Metabolic_Enzyme_21_General_References:
12270127; 12693554; 11780052

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
5976

# Metabolic_Enzyme_22_Name:
Glutamate decarboxylase 1

# Metabolic_Enzyme_22_Synonyms:
Glutamate decarboxylase 67 kDa isoform; GAD-67; 67 kDa glutamic acid decarboxylase

# Metabolic_Enzyme_22_Gene_Name:
GAD1

# Metabolic_Enzyme_22_Protein_Sequence:
>Glutamate decarboxylase 1
MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEK
SRLVSAFKERQSSKNLLSCENSDRDARFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEV
VDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGV
RTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWS
SKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTSEQSHYSIKKAGAA
LGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDPIQEIA
DICEKYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKE
KGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQI
NKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAP
KIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL

# Metabolic_Enzyme_22_Number_of_Residues:
594

# Metabolic_Enzyme_22_Molecular_Weight:
66897

# Metabolic_Enzyme_22_Theoretical_pI:
7.67

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_22_Specific_Function:
Catalyzes the production of GABA

# Metabolic_Enzyme_22_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00410  beta-Alanine metabolism;
 map00430  Taurine and hypotaurine metabolism;
 map00650  Butanoate metabolism

# Metabolic_Enzyme_22_Reaction:
L-glutamate = 4-aminobutanoate + CO2

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF00282:Pyridoxal_deC

# Metabolic_Enzyme_22_Signals:
None

# Metabolic_Enzyme_22_Transmembrane_Regions:
None

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 4.1.1.15

# Metabolic_Enzyme_22_GenBank_ID_Protein:
182936

# Metabolic_Enzyme_22_SwissProt_ID:
DCE1_HUMAN (Q99259)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
GAD1

# Metabolic_Enzyme_22_Geneatlas_id:
GAD1

# Metabolic_Enzyme_22_hgnc_id:
HGNC:4092

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Not Available

# Metabolic_Enzyme_22_Gene_Sequence:
>1785 bp
ATGGCGTCTTCGACCCCATCTTCGTCCGCAACCTCCTCGAACGCGGGAGCGGACCCCAAT
ACCACTAACCTGCGCCCCACAACGTACGATACCTGGTGCGGCGTGGCCCATGGATGCACC
AGAAAACTGGGGCTCAAGATCTGCGGCTTCTTGCAAAGGACCAACAGCCTGGAAGAGAAG
AGTCGCCTTGTGAGTGCCTTCAGGGAGAGGCAATCCTCCAAGAACCTGCTTTCCTGTGAA
AACAGCGACCGGGATGCCCGCTTCCGGCGCACAGAGACTGACTTCTCTAATCTGTTTGCT
AGAGATCTGCTTCCGGCTAAGAACGGTGAGGAGCAAACCGTGCAATTCCTCCTGGAAGTG
GTGGACATACTCCTCAACTATGTCCGCAAGACATTTGATCGCTCCACCAAGGTGCTGGAC
TTTCATCACCCACACCAGTTGCTGGAAGGCATGGAGGGCTTCAACTTGGAGCTCTCTGAC
CACCCCGAGTCCCTGGAGCAGATCCTGGTTGACTGCAGAGACACCTTGAAGTATGGGGTT
CGCACAGGTCATCCTCGATTTTTCAACCAGCTCTCCACTGGATTGGATATTATTGGCCTA
GCTGGAGAATGGCTGACATCAACGGCCAATACCAACATGTTTACATATGAAATTGCACCA
GTGTTTGTCCTCATGGAACAAATAACACTTAAGAAGATGAGAGAGATAGTTGGATGGTCA
AGTAAAGATGGTGATGGGATATTTTCTCCTGGGGGCGCCATATCCAACATGTACAGCATC
ATGGCTGCTCGCTACAAGTACTTCCCGGAAGTTAAGACAAAGGGCATGGCGGCTGTGCCT
AAACTGGTCCTCTTCACCTCAGAACAGAGTCACTATTCCATAAAGAAAGCTGGGGCTGCA
CTTGGCTTTGGAACTGACAATGTGATTTTGATAAAGTGCAATGAAAGGGGGAAAATAATT
CCAGCTGATTTTGAGGCAAAAATTCTTGAAGCCAAACAGAAGGGATATGTTCCCTTTTAT
GTCAATGCAACTGCTGGCACGACTGTTTATGGAGCTTTTGATCCGATACAAGAGATTGCA
GATATATGTGAGAAATATAACCTTTGGTTGCATGTCGATGCTGCCTGGGGAGGTGGGCTG
CTCATGTCCAGGAAGCACCGCCATAAACTCAACGGCATAGAAAGGGCCAACTCAGTCACC
TGGAACCCTCACAAGATGATGGGCGTGCTGTTGCAGTGCTCTGCCATTCTCGTCAAGGAA
AAGGGTATACTCCAAGGATGCAACCAGATGTGTGCAGGATATCTCTTCCAGCCAGACAAG
CAGTATGATGTCTCCTACGACACCGGGGACAAGGCAATTCAGTGTGGCCGCCACGTGGAT
ATCTTCAAGTTCTGGCTGATGTGGAAAGCAAAGGGCACAGTGGGATTTGAAAACCAGATC
AACAAATGCCTGGAACTGGCTGAATACCTCTATGCCAAGATTAAAAACAGAGAAGAATTT
GAGATGGTTTTCAATGGCGAGCCTGAGCACACAAACGTCTGTTTTTGGTATATTCCACAA
AGCCTCAGGGGTGTGCCAGACAGCCCTCAACGACGGGAAAAGCTACACAAGGTGGCTCCA
AAAATCAAAGCCCTGATGATGGAGTCAGGTACGACCATGGTTGGCTACCAGCCCCAAGGG
GACAAGGCCAACTTCTTCCGGATGGTCATCTCCAACCCAGCCGCTACCCAGTCTGACATT
GACTTCCTCATTGAGGAGATAGAAAGACTGGGCCAGGATCTGTAA

# Metabolic_Enzyme_22_GenBank_ID_Gene:
M81883

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_22_Locus:
2q31

# Metabolic_Enzyme_22_SNPs:
rs769402; rs769403; rs41526346; rs769401; rs11542313; rs769395; rs2270335; rs769399; rs3749034; rs1049730; rs3762553; rs769406; rs769409; rs2058725; rs769391; rs769411; rs3791861; rs3791856; rs2270334; rs701492; rs4668331; rs3791857; rs769393; rs3791875; rs3791853; rs3791876; rs2302659; rs3791877; rs769390; rs3791862; rs10439259; rs2234728; rs4668329; rs2241164; rs3791860; rs7561581; rs3791850; rs6716794; rs3791865; rs3791858; rs2241165; rs3791851; rs7578661; rs3828275; rs6433253; rs16858977; rs3791866; rs16858988; rs6433252; rs3749033; rs34210682; rs12612498; rs769405; rs3791871; rs4668330; rs11900444; rs11896169; rs769408; rs3791874; rs3791859; rs4668327; rs41464547; rs41393845; rs1420385; rs1548902; rs41496949; rs1477061; rs11896015; rs701491; rs3791864; rs3791872; rs10930441; rs11890416; rs10191129; rs11895404; rs769407; rs3791855; rs2234727; rs11890409; rs3762556; rs3791878; rs6755370; rs3762557; rs3749035; rs3791879; rs6755371; rs3791880; rs2356236; rs3762554; rs4668324; rs872124; rs3762555; rs1049731; rs1049736; rs17857149; rs17857148; rs1049735; rs34856125; rs34100397; rs1049733; rs1049734; rs35426017; rs3049870; rs5836306; rs34510522; rs34365430; rs35367730; rs35542409; rs954947; rs17752543; rs13017667; rs35495756; rs3791868; rs10698625; rs3049892; rs11338558; rs11331088; rs41265947; rs3791852; rs13035478; rs769394; rs35089719; rs13018052; rs3838551; rs34072956; rs2160415; rs769389; rs34265473; rs13385854; rs2160414; rs11338557; rs34462898; rs13014614; rs35050499; rs3791867; rs4668332; rs13017665; rs3828274; rs35232338; rs34347776; rs13000989; rs35659093; rs4668325; rs10698618; rs34528852; rs3791873; rs7602684; rs12995992; rs35050304; rs6753612; rs35212610; rs10179059; rs35492651; rs3838552; rs7576933; rs41304175; rs34884445; rs10529529; rs13028093; rs35845895; rs41315874; rs28514878; rs3749032; rs3791854; rs35445717; rs769398; rs5836308; rs12991140; rs13014984; rs13033900; rs3791869; rs11333718; rs3791863; rs10605864; rs7594314; rs4667661; rs34291719; rs3791870; rs11314645; rs35495071; rs769410; rs4536622; rs10623405; rs35403424; rs4668326; rs3838550; rs10930442; rs3838553; rs35991368; rs4668328; rs13014595; rs7595288; rs11327360; rs35566565; rs35379843; rs41311313; rs5836305; rs1362492; rs4667659; rs3762558; rs4667660; rs6755102; rs6758358; rs33918896; rs34236419; rs10803852; rs10930443; rs11682957; rs11694200; rs11904485; rs12185692; rs12472230; rs12614879; rs12999141; rs13432752; rs16858996; rs17701824; rs1978340; rs2160413; rs2192987; rs28642888; rs3762560; rs3762561; rs4389303; rs4667662; rs4667663; rs6433254; rs6433255; rs6433256; rs6433257; rs6433261; rs6755814; rs7564761; rs7577421

# Metabolic_Enzyme_22_General_References:
1549570; 8088791; 1339255; 8507202; 8507203; 10671565; 2039509; 1697032

# Metabolic_Enzyme_22_References:
Not Available

# Metabolic_Enzyme_23_ID:
5480

# Metabolic_Enzyme_23_Name:
4-aminobutyrate aminotransferase, mitochondrial precursor

# Metabolic_Enzyme_23_Synonyms:
(S-3-amino-2-methylpropionate transaminase; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA aminotransferase; GABA-AT; GABA-T; L-AIBAT

# Metabolic_Enzyme_23_Gene_Name:
ABAT

# Metabolic_Enzyme_23_Protein_Sequence:
>4aminobutyrate aminotransferase, mitochondrial precursor
MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMK
QLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQ
NASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYR
SKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPS
FDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGG
DNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMM
TGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLL
DLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVF
RDHHAHLFLNIFSDILADFK

# Metabolic_Enzyme_23_Number_of_Residues:
500

# Metabolic_Enzyme_23_Molecular_Weight:
56440

# Metabolic_Enzyme_23_Theoretical_pI:
8.04

# Metabolic_Enzyme_23_GO_Classification:
>>>
Function:  4-aminobutyrate transaminase activity
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid derivative metabolism
Process:  gamma-aminobutyric acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_23_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_23_Specific_Function:
Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine

# Metabolic_Enzyme_23_Pathway:
map00280  Valine, leucine and isoleucine degradation;
GENES       ECO: b2662(gabT);
            ECJ: JW2637(gabT);
            ECE: Z3960(gabT);
            ECS: ECs3523;
            ECC: c3210(gabT);
            STY: STY2912(gabT);
            STT: t2687(gabT);
            SPT: SPA2649(gabT);
            SEC: SC2724(gabT);
            STM: STM2792(gabT);
            YPE: YPO2844(goaG);
            YPK: y1390(goaG);
            YPM: YP2711(goaG);
            YPS: YPTB2810(goaG);
            SFL: SF2689(gabT);
            SFX: S2874(gabT);
            ECA: ECA2053(gabT);
            PLU: plu2347(goaG);
            VPA: VP1771;
            PAE: PA0266(gabT);
            PPU: PP0214(gabT);
            PST: PSPTO0301(gabT-2);
            PSB: Psyr_0090;
            ACI: ACIAD3446(gabT);
            SON: SO1276(gabT);
            CVI: CV3926(goaG);
            RSO: RSc0029(goaG);
            BMA: BMAA1480(gabT);
            BPS: BPSS0281(gabT);
            BPE: BP2298;
            BPA: BPP2431;
            BBR: BB1880;
            MLO: mlr5521;
            SME: SMb21186(gabT);
            RPA: RPA2323(goaT);
            SIL: SPOA0274(gabT);
            BAN: BA0325(gabT);
            BAR: GBAA0325(gabT);
            BAA: BA_0895;
            BAT: BAS0310;
            BCA: BCE0354(gabT);
            BCZ: BCZK0297(gabT)

# Metabolic_Enzyme_23_Reaction:
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF00202:Aminotran_3

# Metabolic_Enzyme_23_Signals:
None

# Metabolic_Enzyme_23_Transmembrane_Regions:
None

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 2.6.1.19;EC 2.6.1.22

# Metabolic_Enzyme_23_GenBank_ID_Protein:
602705

# Metabolic_Enzyme_23_SwissProt_ID:
GABT_HUMAN (P80404)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
ABAT

# Metabolic_Enzyme_23_Geneatlas_id:
ABAT

# Metabolic_Enzyme_23_hgnc_id:
HGNC:23

# Metabolic_Enzyme_23_PDB_ID:
1OHY

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_23_Gene_Sequence:
>1503 bp
ATGGCCTCCATGTTGCTCGCCCAGCGGCTGGCCTGCAGCTTCCAGCACACGTACCGCCTG
CTGGTGCCTGGATCCAGACACATTAGTCAAGCTGCAGCCAAAGTCGACGTTGAATTTGAT
TATGATGGGCCTCTGATGAAGACGGAAGTCCCAGGGCCTAGATCTCAGGAGTTAATGAAA
CAGCTGAATATAATTCAGAATGCAGAGGCTGTGCATTTTTTCTGCAATTACGAAGAGAGC
CGAGGCAATTACCTGGTTGATGTGGACGGCAACCGAATGCTGGATCTTTATTCCCAGATC
TCCTCTGTTCCCATAGGTTACAGCGACCCGGCCCTCGTGAAACTCATCCAACAGCCACAA
AATGCGAGCATGTTTGTCAACAGACCCGCCCTCGAAATCCTGCCTCCGGAGAACTTTGTG
GAGAAGCTCCGGCAGTCCTTGCTCTCGGTGGCTCCCAAAGGGATGTCCCAGCTCATCACC
ATGGCCTGCGGCTCCTGCTCCAATGAAAACGCCTTAAAGACCATCTTCATGTGGTACCGG
AGCAAGGAAAGAGGGCAGAGGGGATTCTCCAAAGAGGAGCTGGAGACGTGCATGATTAAC
CAGGCCCCCTGGTGCCCCGACTACAGCATCCTCTCCTTCATGGGTTCCTTCCATGGGAGG
ACCATGGGTTGCTTAGCGACCACGCACTCTAAAGCCATTCACAAGATCGATATCCCTTCC
TTTGACTGGCCCATCGCACCGTTCCCACGGCTGAAATACCCTCTGGAAGAGTTTGTGAAA
GAGAACCAACAGGAAGAGGCCGGCTGTCTGGAAGAGGTTGAGGATCTGATTGTGAAATAT
CGAAAAAAGAAGAAGACGGTGGCCGGGATCATCGTGGAGCCCATCCAGTCCGAGGGTGGA
GACAACCATGCATCCGATGACTTCTTTCGGAAGCTGAGAGACATCGCCAGGAAGCACTGC
TGCGCCTTCTTGGTGGACGAGGTCCAGACCGGAGGAGGCTGCACGGGCAAGTTCTGGGCC
CATGAGCACTGGGGCCTGGATGACCCAGCAGACGTGATGACCTTCAGCAAGAAGATGATG
ACTGGGGGCTTCTTCCTCAAGGAGGAGTTCAGGCCTAATGCTCCCTACCGGATCTTCAAC
ACGTGGCTGGGGGACCCGTCCAAGAACCTGTTGCTGGCTGAGGTCATCAACATCATCAAG
CGGGAGGACCTGCTAAATAATGCAGCCCATGCCGGGAAGGCCCTGCTCACAGGACTGCTG
GACCTCCAGGCCCGGTACCCCCAGTTCATCAGCAGGGTGAGAGGACGAGGCACCTTTTGC
TCCTTCGATACTCCCGATGATTCCATACGGAATAAGCTCATTTTAATTGCCAGAAACAAA
GGTGTGGTGTTGGGTGGCTGTGGTGACAAATCCATTCGTTTCCGTCCCACGCTGGTGTTC
AGGGATCACCACGCTCACCTGTTCCTCAATATTTTCAGTGACATCTTAGCAGACTTCAAG
TAA

# Metabolic_Enzyme_23_GenBank_ID_Gene:
L32961

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_23_Locus:
16p13.2

# Metabolic_Enzyme_23_SNPs:
rs1731017; rs1641022; rs28687443; rs1731062; rs1006636; rs747329; rs1730951; rs1273350; rs1273394; rs1730948; rs4454975; rs3743801; rs1730946; rs6497519; rs1730941; rs2313427; rs1641113; rs1273364; rs4984996; rs1641107; rs747330; rs1273396; rs11075408; rs6497548; rs1730945; rs6497583; rs1295741; rs1641112; rs1273373; rs1640989; rs1273357; rs4985113; rs8062395; rs1730952; rs7205816; rs1641032; rs3108684; rs1730954; rs1273393; rs7199025; rs4985114; rs4985036; rs1730958; rs9935902; rs1641110; rs6497327; rs4985000; rs1273351; rs8055836; rs1641108; rs1344476; rs1730938; rs1730953; rs1730943; rs1641111; rs1730937; rs4984997; rs17566580; rs737695; rs3095512; rs1289964; rs1273360; rs1273397; rs9456; rs1273381; rs1273359; rs1731071; rs1273353; rs1640997; rs3743798; rs1273355; rs9935408; rs6498753; rs17674530; rs1273356; rs12933164; rs1273376; rs1730956; rs1273361; rs1273390; rs12447371; rs12596289; rs1731083; rs1641031; rs12445987; rs12597124; rs4445904; rs11648372; rs1640995; rs1730961; rs1273395; rs11645254; rs9935422; rs1295740; rs11647162; rs4984998; rs11646372; rs1273366; rs1640979; rs7499026; rs2313548; rs6498755; rs1640980; rs3095514; rs1273372; rs1273363; rs6497565; rs11074405; rs1273358; rs1731061; rs1273382; rs1730955; rs1273352; rs1273367; rs7499025; rs1640971; rs7201586; rs1730949; rs1640974; rs1641106; rs8052707; rs1612155; rs1273391; rs12596654; rs12448579; rs1641109; rs1807439; rs8056063; rs1273349; rs1731081; rs1731082; rs9923953; rs8059639; rs3095516; rs1730944; rs11642785; rs8061555; rs1061842; rs1641105; rs8056550; rs12149040; rs1731078; rs7194430; rs1730959; rs1420082; rs12448693; rs12597484; rs737696; rs1273380; rs1273370; rs8058062; rs1640973; rs1731069; rs1730947; rs1731085; rs1731079; rs2270289; rs3095515; rs1640978; rs1640981; rs1730962; rs1640996; rs9939980; rs1123891; rs8054014; rs1273369; rs1730957; rs9928478; rs8046210; rs12921061; rs2270288; rs7501036; rs11648678; rs1273383; rs1273362; rs11643667; rs1730939; rs1881828; rs1640988; rs2313596; rs12444390; rs1731080; rs17651562; rs16964282; rs9935013; rs7193087; rs11866675; rs8275; rs10261; rs12445958; rs1731070; rs737694; rs8048045; rs7192026; rs7197787; rs8050233; rs1640994; rs3095513; rs8049263; rs12447028; rs11643578; rs3095510; rs1641021; rs9674265; rs8057362; rs1273427; rs1641024; rs1273398; rs1273422; rs1273424; rs2091634; rs7196462; rs1273430; rs1640998; rs8053509; rs8049072; rs9673595; rs12708689; rs4985035; rs1641003; rs1641019; rs6497960; rs7197673; rs1273425; rs12447235; rs1273429; rs8055880; rs1641025; rs1273433; rs3815507; rs1079350; rs4482281; rs11863437; rs1273423; rs1731039; rs1731019; rs1640999; rs1641007; rs12446980; rs12925086; rs13337024; rs13336159; rs9937726; rs933481; rs1273431; rs1641014; rs12446169; rs8060255; rs1641002; rs1078509; rs1273417; rs1641027; rs1641016; rs1731027; rs12448959; rs6497959; rs1273428; rs1079348; rs11862060; rs11074631; rs2103340; rs753071; rs1731026; rs1731072; rs1299926; rs1273420; rs8055737; rs12448823; rs1079349; rs1731086; rs7203297; rs1273406; rs3815508; rs1641001; rs8061093; rs9937937; rs9302405; rs11640989; rs8056083; rs11866199; rs1273426; rs9924807; rs1273419; rs1273402; rs1641030; rs7206830; rs1273421; rs8053030; rs12596790; rs8046201; rs11865147; rs1731087; rs1731073; rs13338443; rs1273415; rs12918897; rs1641010; rs8055927; rs11074534; rs13335330; rs1731030; rs1641015; rs9929124; rs10775278; rs1641023; rs1420084; rs9673228; rs7193333; rs1990574; rs1894861; rs1965648; rs1078511; rs1731020; rs1641008; rs1731034; rs1273407; rs1612383; rs11647952; rs2464048; rs1731018; rs9673371; rs7193305; rs1641011; rs1273416; rs1273400; rs11074713; rs1641029; rs9673409; rs1465319; rs1965649; rs1420085; rs10775279; rs11860865; rs12445730; rs11641035; rs1273408; rs7200886; rs1630164; rs13332999; rs1731029; rs1273401; rs1616856; rs1273412; rs1273418; rs12445609; rs11074695; rs8057162; rs13336186; rs11074533; rs1075853; rs1273413; rs11074712; rs3217123; rs9673401; rs1641026; rs12922831; rs12445687; rs13332215; rs12102631; rs12598074; rs12444233; rs1731036; rs1641006; rs12930556; rs12325344; rs933482; rs13339338; rs1613314; rs1965647; rs8061716; rs4989413; rs2302608; rs1641013; rs8048375; rs1617601; rs12448478; rs1273410; rs1465318; rs8060512; rs1641017; rs12149331; rs13331042; rs8047293; rs4984999; rs11646271; rs10852271; rs9925620; rs10775277; rs8060323; rs9931017; rs1420083; rs7203550; rs1641104; rs1139523; rs1139520; rs35780038; rs41311264; rs1139522; rs1062593; rs1139525; rs34813662; rs1042495; rs1139521; rs1139519; rs8059762; rs35850996; rs1273386; rs1640972; rs34187437; rs12597184; rs28415910; rs7195521; rs36138946; rs28587720; rs1640985; rs12149146; rs1731059; rs34441266; rs28403171; rs9939846; rs1640993; rs1273377; rs34595424; rs35454761; rs1273378; rs7195079; rs35916063; rs1640987; rs1273371; rs9928667; rs4296259; rs13334372; rs28382303; rs35255805; rs33951087; rs1630895; rs1731084; rs1273388; rs16964376; rs34014796; rs35351214; rs1730950; rs7184890; rs34724138; rs1640977; rs4442807; rs1731064; rs17651173; rs7204053; rs1273374; rs1730960; rs2178371; rs1640975; rs3095511; rs2160182; rs13337410; rs35163930; rs28692588; rs8056066; rs34165726; rs1731075; rs35012807; rs35638621; rs1640986; rs5815494; rs28602865; rs1273368; rs1640992; rs28622536; rs1731058; rs12149145; rs7190843; rs28714127; rs35832558; rs8056594; rs1986108; rs33928355; rs1640984; rs34006471; rs8060892; rs28742255; rs9746220; rs12926736; rs35163795; rs1273365; rs34531177; rs3065947; rs1640991; rs34595884; rs34089650; rs35176944; rs34736230; rs2313428; rs10163233; rs1731057; rs8049522; rs730750; rs34452392; rs9941133; rs34403235; rs34698480; rs1640970; rs34686381; rs8056020; rs7196194; rs35069718; rs28581915; rs28589960; rs8046394; rs34733640; rs1640983; rs12446703; rs13337518; rs28609006; rs1730942; rs1731076; rs7187850; rs35596444; rs8046003; rs28864687; rs1640990; rs12325121; rs8046571; rs9931939; rs8044285; rs7203755; rs41312250; rs8062725; rs28618356; rs13338663; rs7195524; rs28650912; rs35853974; rs34216922; rs13333072; rs10163342; rs12925473; rs1273379; rs7499024; rs1273387; rs5815492; rs13338551; rs7498949; rs34887951; rs28397834; rs7196287; rs28568507; rs2052235; rs34327953; rs34516341; rs28679855; rs35724649; rs11861413; rs7206673; rs2160181; rs1627524; rs35141742; rs1731077; rs1641114; rs13336886; rs12149463; rs35336676; rs34655579; rs9934284; rs35896679; rs1730940; rs8046260; rs1273375; rs28430948; rs3069301; rs35773832; rs28483683; rs5815493; rs11642744; rs8052663; rs1273389; rs12445001; rs35804023; rs35621836; rs1273392; rs3108683; rs34943374; rs1640982; rs35771183; rs4985115; rs1640976; rs1731088; rs12932819; rs35772192; rs34403809; rs34264472; rs9931477; rs8063475; rs1731024; rs11862275; rs36095894; rs753070; rs1273403; rs1298679; rs1630161; rs34085775; rs28785577; rs7192987; rs33948976; rs13337697; rs3069345; rs12924611; rs1731068; rs1465317; rs13339388; rs28557212; rs34198010; rs6497761; rs7188839; rs13337020; rs12921235; rs28669991; rs12598010; rs1078510; rs1320812; rs35617486; rs13338915; rs12445356; rs9674283; rs36191361; rs1273404; rs11647647; rs34543657; rs7198302; rs12924829; rs34544015; rs36181426; rs1627098; rs1731038; rs9923086; rs1273411; rs36055711; rs10153069; rs1641004; rs1731033; rs1657081; rs35468187; rs13337062; rs7200508; rs7185579; rs35255659; rs11649570; rs34994165; rs35503372; rs12598506; rs1641018; rs1731037; rs34598069; rs34415556; rs41307917; rs11648982; rs34761392; rs1273405; rs1548863; rs1641000; rs34630251; rs2464049; rs28568366; rs12930438; rs7205552; rs1299925; rs9941328; rs28759346; rs34495251; rs1641012; rs34900184; rs1629364; rs11862270; rs9936820; rs9926653; rs34177196; rs41312254; rs7200724; rs9932833; rs35002036; rs12935717; rs28852097; rs1273409; rs35359682; rs753072; rs10852270; rs28427346; rs35691630; rs11640314; rs10775276; rs1731025; rs28495577; rs34651404; rs34982194; rs35248639; rs36034133; rs1078508; rs12149630; rs35745596; rs9926200; rs36000891; rs7187363; rs8060324; rs7189861; rs13339115; rs35414822; rs34346487; rs35585805; rs41303767; rs35010946; rs933480; rs12447747; rs41305755; rs35405936; rs28630033; rs9941032; rs41427146; rs9922301; rs7191001; rs2313560; rs41312252; rs41311266; rs13338171; rs13339497; rs1641005; rs34408519; rs13380503; rs34755382; rs7500881; rs13335619; rs1273432; rs9936647; rs35893143; rs1273414; rs34060423; rs1623647; rs34484640; rs11647644; rs35548548; rs28398424; rs1730964; rs35258023; rs1730963; rs35440533; rs28758216; rs1060784; rs11641192; rs11860988; rs11861249; rs12103329; rs12444391; rs12444975; rs12447079; rs1273384; rs1273385; rs12929416; rs13338256; rs1345300; rs1358692; rs1641098; rs1641099; rs1641100; rs1641101; rs1865805; rs1865806; rs2160180; rs2241103; rs2312957; rs2840195; rs34611261; rs35851221; rs3743811; rs3743812; rs4985110; rs4985111; rs7188782; rs7192702; rs7200823; rs7204765; rs7205295; rs876945; rs9928906

# Metabolic_Enzyme_23_General_References:
7721088; 7851425; 10407778

# Metabolic_Enzyme_23_References:
Not Available

# Metabolic_Enzyme_24_ID:
5446

# Metabolic_Enzyme_24_Name:
Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2

# Metabolic_Enzyme_24_Synonyms:
Hexosephosphate aminotransferase 2; D-fructose-6- phosphate amidotransferase 2; GFAT 2; GFAT2

# Metabolic_Enzyme_24_Gene_Name:
GFPT2

# Metabolic_Enzyme_24_Protein_Sequence:
>Glucosaminefructose6phosphate aminotransferase isomerizing 2
MCGIFAYMNYRVPRTRKEIFETLIKGLQRLEYRGYDSAGVAIDGNNHEVKERHIQLVKKR
GKVKALDEELYKQDSMDLKVEFETHFGIAHTRWATHGVPSAVNSHPQRSDKGNEFVVIHN
GIITNYKDLRKFLESKGYEFESETDTETIAKLIKYVFDNRETEDITFSTLVERVIQQLEG
AFALVFKSVHYPGEAVATRRGSPLLIGVRSKYKLSTEQIPILYRTCTLENVKNICKTRMK
RLDSSACLHAVGDKAVEFFFASDASAIIEHTNRVIFLEDDDIAAVADGKLSIHRVKRSAS
DDPSRAIQTLQMELQQIMKGNFSAFMQKEIFEQPESVFNTMRGRVNFETNTVLLGGLKDH
LKEIRRCRRLIVIGCGTSYHAAVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFF
ISQSGETADTLLALRYCKDRGALTVGVTNTVGSSISRETDCGVHINAGPEIGVASTKAYT
SQFISLVMFGLMMSEDRISLQNRRQEIIRGLRSLPELIKEVLSLEEKIHDLALELYTQRS
LLVMGRGYNYATCLEGALKIKEITYMHSEGILAGELKHGPLALIDKQMPVIMVIMKDPCF
AKCQNALQQVTARQGRPIILCSKDDTESSKFAYKTIELPHTVDCLQGILSVIPLQLLSFH
LAVLRGYDVDFPRNLAKSVTVE

# Metabolic_Enzyme_24_Number_of_Residues:
682

# Metabolic_Enzyme_24_Molecular_Weight:
76932

# Metabolic_Enzyme_24_Theoretical_pI:
7.40

# Metabolic_Enzyme_24_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
Function:  glutamine-fructose-6-phosphate transaminase (isomerizing) activity
 ||
>>>
Process:  carbohydrate metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  carbohydrate biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_24_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_24_Specific_Function:
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins

# Metabolic_Enzyme_24_Pathway:
map00251  Glutamate metabolism;
 map00530  Aminosugars metabolism

# Metabolic_Enzyme_24_Reaction:
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate

# Metabolic_Enzyme_24_Pfam_Domain_Function:
PF00310:GATase_2;
PF01380:SIS

# Metabolic_Enzyme_24_Signals:
None

# Metabolic_Enzyme_24_Transmembrane_Regions:
None

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 2.6.1.16

# Metabolic_Enzyme_24_GenBank_ID_Protein:
4239883

# Metabolic_Enzyme_24_SwissProt_ID:
GFPT2_HUMAN (O94808)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
GFPT2

# Metabolic_Enzyme_24_Geneatlas_id:
GFPT2

# Metabolic_Enzyme_24_hgnc_id:
HGNC:4242

# Metabolic_Enzyme_24_PDB_ID:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Not Available

# Metabolic_Enzyme_24_Gene_Sequence:
>2049 bp
ATGTGCGGAATCTTTGCCTACATGAACTACAGAGTCCCCCGGACGAGGAAGGAGATCTTC
GAAACCCTCATCAAGGGCCTGCAGCGGCTGGAGTACAGAGGCTACGACTCGGCAGGTGTG
GCGATCGATGGGAATAATCACGAAGTCAAAGAAAGACACATTCAGCTGGTCAAGAAAAGG
GGGAAAGTCAAGGCTCTCGATGAAGAACTTTACAAACAAGACAGCATGGACTTAAAAGTG
GAGTTTGAGACACACTTCGGCATTGCCCACACGCGCTGGGCCACCCACGGGGTCCCCAGT
GCTGTCAACAGCCACCCTCAGCGCTCAGACAAAGGCAACGAATTTGTTGTCATCCACAAT
GGGATCATCACAAATTACAAAGATCTGAGGAAATTTCTGGAAAGCAAAGGCTACGAGTTT
GAGTCAGAAACAGATACAGAGACCATCGCCAAGCTGATTAAATATGTGTTCGACAACAGA
GAAACTGAGGACATTACGTTTTCAACGTTGGTCGAGAGAGTCATTCAGCAGTTGGAAGGT
GCATTCGCGCTGGTTTTCAAGAGTGTCCACTACCCAGGAGAAGCCGTTGCCACACGGAGA
GGCAGCCCCCTGCTCATCGGAGTCCGGAGCAAATACAAGCTCTCCACAGAACAGATCCCT
ATCTTATACAGGACGTGCACTCTGGAGAATGTGAAGAATATCTGTAAGACACGGATGAAG
AGGCTGGACAGCTCCGCCTGCCTGCATGCTGTGGGCGACAAGGCCGTGGAATTCTTCTTT
GCTTCTGATGCAAGCGCTATCATAGAGCACACCAACCGGGTCATCTTCCTGGAGGACGAT
GACATCGCCGCAGTGGCTGATGGGAAACTCTCCATTCACCGGGTCAAGCGCTCGGCCAGT
GATGACCCATCTCGAGCCATCCAGACCTTGCAGATGGAACTGCAGCAAATCATGAAAGGT
AACTTCAGTGCGTTTATGCAGAAGGAGATCTTCGAACAGCCAGAATCAGTTTTCAATACT
ATGAGAGGTCGGGTGAATTTTGAAACCAACACAGTGCTCCTGGGTGGCTTGAAGGACCAC
TTGAAGGAGATTCGACGATGCCGACGGCTCATCGTGATTGGCTGTGGAACCAGCTACCAC
GCTGCCGTGGCTACGCGGCAAGTTTTGGAGGAACTGACTGAGCTTCCTGTGATGGTTGAA
CTTGCTAGTGATTTTCTGGACAGGAACACACCTGTGTTCAGGGATGACGTTTGCTTTTTC
ATCAGCCAGTCAGGCGAGACCGCGGACACCCTCCTGGCGCTGCGCTACTGTAAGGACCGC
GGCGCTCTCACCGTGGGCGTCACCAACACCGTGGGCAGCTCCATCTCTCGCGAGACCGAC
TGCGGCGTCCACATCAACGCAGGGCCGGAGATCGGCGTGGCCAGCACCAAGGCTTATACC
AGTCAGTTCATCTCTCTGGTGATGTTTGGTTTGATGATGTCTGAAGACCGAATTTCACTA
CAAAACAGGAGGCAAGAGATCATCCGTGGCTTGAGATCTTTACCTGAGCTGATCAAGGAA
GTGCTGTCTCTGGAGGAGAAGATCCACGACTTGGCCCTGGAGCTCTACACGCAGAGATCG
CTGCTGGTGATGGGGCGGGGCTACAACTATGCCACCTGCCTGGAAGGAGCCCTGAAAATT
AAAGAGATAACCTACATGCACTCAGAAGGCATCCTGGCTGGGGAGCTGAAGCACGGGCCC
CTGGCACTGATTGACAAGCAGATGCCCGTCATCATGGTCATTATGAAGGATCCTTGCTTC
GCCAAATGCCAGAACGCCCTGCAGCAAGTCACGGCCCGCCAGGGTCGCCCCATTATACTG
TGCTCCAAGGACGATACTGAAAGTTCCAAGTTTGCGTATAAGACAATTGAGCTGCCCCAC
ACTGTGGACTGCCTCCAGGGCATCCTGAGCGTGATTCCGCTGCAGCTGCTGTCCTTCCAC
CTGGCTGTTCTCCGAGGATATGACGTTGACTTCCCCAGAAATCTGGCCAAGTCTGTAACT
GTGGAATGA

# Metabolic_Enzyme_24_GenBank_ID_Gene:
AB016789

# Metabolic_Enzyme_24_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_24_Locus:
5q34-q35

# Metabolic_Enzyme_24_SNPs:
rs2303007; rs2112594; rs1035411; rs1559113; rs6601109; rs2303012; rs729568; rs7720626; rs10043913; rs4700733; rs3763131; rs3828686; rs888924; rs729652; rs4700942; rs888922; rs878706; rs6891083; rs2303005; rs7715919; rs13179839; rs12521558; rs3828688; rs1559114; rs17080199; rs888926; rs7707082; rs17080201; rs4543227; rs6893693; rs11249702; rs12514698; rs2080959; rs2386859; rs9687074; rs4432844; rs1078646; rs2042225; rs7730414; rs2386855; rs11249704; rs888925; rs2080957; rs6874653; rs11249703; rs11960659; rs10794704; rs7719192; rs4700939; rs4700931; rs2386858; rs4700941; rs4700940; rs7701459; rs1035412; rs4566752; rs6879260; rs1007838; rs6893651; rs13164734; rs1008025; rs7715132; rs10903253; rs11249701; rs7725605; rs12654592; rs2080958; rs888927; rs12523555; rs3805703; rs2303010; rs2386854; rs4700932; rs6869637; rs3749788; rs1363517; rs11951669; rs11249699; rs6859159; rs2303008; rs2386856; rs2386857; rs10794705; rs12651762; rs10903252; rs11740631; rs17080196; rs9686940; rs4529151; rs4425468; rs4700933; rs4537018; rs6887811; rs13172268; rs11742980; rs12519247; rs4235511; rs6887820; rs6601111; rs12521640; rs13188590; rs12516159; rs2042224; rs2303011; rs9686363; rs11738309; rs4700736; rs11744256; rs11747494; rs11747298; rs1422574; rs878705; rs6874176; rs12521644; rs6601108; rs4323198; rs2080955; rs6864729; rs6601110; rs17080160; rs7730585; rs11249694; rs2303009; rs2386853; rs13158872; rs6887601; rs11745449; rs7727934; rs11960688; rs2892153; rs12518499; rs7447624; rs6871454; rs7706951; rs9686362; rs4700735; rs2080956; rs7704402; rs11960633; rs4627952; rs11953989; rs3805705; rs6873614; rs1422572; rs1422573; rs3841145; rs36046599; rs11557568; rs35765078; rs5873686; rs1801853; rs3080055; rs4700731; rs12654320; rs6881795; rs11249700; rs11282010; rs6896695; rs34735703; rs35987549; rs6874433; rs734090; rs28380364; rs34416707; rs35259770; rs7704535; rs11356791; rs34831746; rs34778234; rs35211599; rs35223258; rs3217233; rs28700193; rs4700732; rs12655822; rs12652060; rs34342936; rs35460637; rs6896556; rs35808074; rs4493635; rs34704166; rs11278352; rs11741142; rs4700935; rs2892151; rs28507693; rs11749513; rs6873632; rs36224110; rs11322913; rs4700936; rs3749789; rs12332177; rs11249696; rs4700734; rs1540381; rs34154535; rs28667546; rs10479468; rs11278350; rs7735562; rs35303775; rs6883213; rs6871472; rs35017920; rs5873683; rs4700937; rs4700943; rs5873685; rs10551893; rs28562930; rs2892152; rs11341578; rs10052131; rs3805704; rs28433941; rs10579752; rs34473901; rs35625998; rs36068774; rs34172114; rs11249698; rs6866561; rs34163399; rs34236296; rs12055278; rs28729800; rs34611349; rs34871146; rs6892511; rs35690024; rs4574507; rs13163031; rs34154763; rs9329105; rs35605149; rs13161805; rs5873684; rs11741959; rs34467703; rs34992800; rs13171554; rs35251405; rs28469539; rs6873631; rs11278351; rs10479571; rs4419558; rs4700934; rs3828687; rs34335690; rs13157758; rs34330028; rs34036795; rs1540382; rs6882022; rs28696251; rs10610483; rs968590; rs6872946; rs1422575; rs35515756; rs6879034; rs7724653; rs11744073; rs1964288; rs35832337; rs34184127; rs34016478; rs12173080; rs11249695; rs35674568; rs36114573; rs10689521; rs11249697; rs11748848; rs35861097; rs34123923; rs28719732; rs35451492; rs35581043; rs4700938; rs34004331; rs6867143; rs35331042; rs34253331; rs6878656; rs35975547; rs10674209; rs7449271; rs6870028; rs34808044; rs34118046; rs11742984; rs1363512; rs5873690; rs33964530; rs3841144; rs5873688; rs4572964; rs1363511; rs35485679; rs5873687; rs5024016; rs34264498; rs5873689; rs35956632; rs3812068; rs34522925; rs35864082; rs11452117; rs3841143; rs10041598; rs10054994; rs11748619; rs11748698; rs12520876; rs12652232; rs1363513; rs1363514; rs1363515; rs1363516; rs1559116; rs2277934; rs35809530; rs3749791; rs3749792; rs3749795; rs3749796; rs4235510; rs6884111; rs7703402; rs7711688; rs7725; rs7728986; rs880528; rs9329106

# Metabolic_Enzyme_24_General_References:
10198162

# Metabolic_Enzyme_24_References:
Not Available

# Metabolic_Enzyme_25_ID:
5763

# Metabolic_Enzyme_25_Name:
Branched-chain-amino-acid aminotransferase, mitochondrial precursor

# Metabolic_Enzyme_25_Synonyms:
BCAT(m; Placental protein 18; PP18

# Metabolic_Enzyme_25_Gene_Name:
BCAT2

# Metabolic_Enzyme_25_Protein_Sequence:
>Branchedchainaminoacid aminotransferase, mitochondrial precursor
MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKT
FTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRP
WLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSL
GVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLV
QQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQS
LLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIP
TMENGPELILRFQKELKEIQYGIRAHEWMFPV

# Metabolic_Enzyme_25_Number_of_Residues:
392

# Metabolic_Enzyme_25_Molecular_Weight:
44288

# Metabolic_Enzyme_25_Theoretical_pI:
8.82

# Metabolic_Enzyme_25_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
Function:  branched-chain-amino-acid transaminase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  branched chain family amino acid metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_25_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_25_Specific_Function:
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids

# Metabolic_Enzyme_25_Pathway:
map00280  Valine, leucine and isoleucine degradation;
 map00290  Valine, leucine and isoleucine biosynthesis;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_25_Reaction:
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate

# Metabolic_Enzyme_25_Pfam_Domain_Function:
PF01063:Aminotran_4

# Metabolic_Enzyme_25_Signals:
1-29

# Metabolic_Enzyme_25_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_25_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_25_EC_Link:
EC 2.6.1.42

# Metabolic_Enzyme_25_GenBank_ID_Protein:
2342862

# Metabolic_Enzyme_25_SwissProt_ID:
BCAT2_HUMAN (O15382)

# Metabolic_Enzyme_25_swissprot_Name:
Not Available

# Metabolic_Enzyme_25_Genecard_id:
BCAT2

# Metabolic_Enzyme_25_Geneatlas_id:
BCAT2

# Metabolic_Enzyme_25_hgnc_id:
HGNC:977

# Metabolic_Enzyme_25_PDB_ID:
1KTA

# Metabolic_Enzyme_25_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_25_Subcellular_Location:
Isoform A:Mitochondrion. Isoform B:Cytoplasm

# Metabolic_Enzyme_25_Gene_Sequence:
>1179 bp
ATGGCCGCAGCCGCTCTGGGGCAGATCTGGGCACGAAAGCTTCTCTCTGTCCCTTGGCTT
CTGTGTGGTCCCAGAAGATATGCCTCCTCCAGTTTCAAGGCTGCAGACCTGCAGCTGGAA
ATGACACAGAAGCCTCATAAGAAGCCTGGCCCCGGCGAGCCCCTGGTGTTTGGGAAGACA
TTTACCGACCACATGCTGATGGTGGAATGGAATGACAAGGGCTGGGGCCAGCCCCGAATC
CAGCCCTTCCAGAACCTCACGCTGCACCCAGCCTCCTCCAGCCTCCACTACTCCCTGCAG
CTGTTTGAGGGCATGAAGGCGTTCAAAGGCAAAGACCAGCAGGTGCGCCTCTTCCGCCCC
TGGCTCAACATGGACCGGATGCTGCGCTCAGCCATGCGCCTGTGCCTGCCGAGTTTCGAC
AAGCTGGAGTTGCTGGAGTGCATCCGCCGGCTCATCGAAGTGGACAAGGACTGGGTCCCC
GATGCCGCCGGCACCAGCCTCTATGTGCGGCCTGTGCTCATTGGGAACGAGCCCTCGCTG
GGTGTCAGCCAGCCCAGGCGCGCGCTCCTGTTCGTCATTCTCTGCCCAGTGGGTGCCTAC
TTCCCTGGAGGCTCCGTGACCCCGGTCTCCCTCCTGGCCGACCCAGCCTTCATCCGGGCC
TGGGTGGGCGGGGTCGGCAACTACAAGTTAGGTGGGAATTATGGGCCCACCGTGTTAGTG
CAACAGGAGGCACTCAAGCGGGGCTGTGAACAGGTCCTCTGGCTGTATGGGCCCGACCAC
CAGCTCACCGAGGTGGGAACCATGAACATCTTTGTCTACTGGACCCACGAAGATGGGGTG
CTGGAGCTGGTGACGCCCCCGCTGAATGGTGTTATCCTGCCTGGAGTGGTCAGACAGAGT
CTACTGGACATGGCTCAGACCTGGGGTGAGTTCCGGGTGGTGGAGCGCACGATCACCATG
AAGCAGTTGCTGCGGGCCTTGGAGGAGGGCCGCGTGCGGGAAGTCTTTGGCTCGGGCACC
GCTTGCCAGGTCTGCCCAGTGCACCGAATCCTGTACAAAGACAGGAACCTCCATATTCCC
ACCATGGAAAATGGGCCTGAGCTGATCCTCCGCTTCCAGAAGGAGCTGAAGGAGATCCAG
TACGGAATCAGAGCCCACGAGTGGATGTTCCCGGTGTGA

# Metabolic_Enzyme_25_GenBank_ID_Gene:
U68418

# Metabolic_Enzyme_25_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_25_Locus:
19q13

# Metabolic_Enzyme_25_SNPs:
rs11548193; rs837642; rs736170; rs566869; rs491459; rs4802507; rs4802509; rs4802508; rs521398; rs557106; rs12461998; rs4802510; rs11881788; rs575737; rs7257533; rs857526; rs4802504; rs35829476; rs526744; rs4801775; rs4801776; rs4802505; rs493841; rs6509405; rs684959; rs7249134; rs11665957; rs11548194; rs11548192; rs1132361; rs1052611; rs1052625; rs5828363; rs34189956; rs7251049; rs11310101; rs487703; rs41347145; rs7256054; rs7252854; rs11460106; rs35104437; rs3057799; rs35321803; rs35330344; rs34746454; rs11426980; rs12978094; rs11672905; rs10624703; rs34719140; rs34860510; rs11882009; rs11673677; rs12985962; rs35890345; rs34816112; rs12984148; rs35775607; rs35150864; rs35945446; rs4802506; rs34867589; rs11671146; rs35230038; rs10408884; rs36021046; rs35343377; rs36046536; rs1045379; rs11670491; rs11881731; rs11881904; rs12974796; rs2098684; rs3185254; rs35299026; rs3760788; rs482226; rs511779; rs524581; rs524942; rs545587; rs624028; rs656190; rs704244

# Metabolic_Enzyme_25_General_References:
9165094; 11170829; 8702755; 11264579; 12269802

# Metabolic_Enzyme_25_References:
Not Available

# Metabolic_Enzyme_26_ID:
5615

# Metabolic_Enzyme_26_Name:
Kynurenine/alpha-aminoadipate aminotransferase mitochondrial precursor

# Metabolic_Enzyme_26_Synonyms:
KAT/AadAT; Kynurenine--oxoglutarate transaminase II; Kynurenine aminotransferase II; Kynurenine--oxoglutarate aminotransferase II; 2-aminoadipate transaminase; 2- aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AadAT

# Metabolic_Enzyme_26_Gene_Name:
AADAT

# Metabolic_Enzyme_26_Protein_Sequence:
>Kynurenine/alphaaminoadipate aminotransferase mitochondrial precursor
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
IKESL

# Metabolic_Enzyme_26_Number_of_Residues:
425

# Metabolic_Enzyme_26_Molecular_Weight:
47352

# Metabolic_Enzyme_26_Theoretical_pI:
6.96

# Metabolic_Enzyme_26_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_26_General_Function:
Transcription 

# Metabolic_Enzyme_26_Specific_Function:
Shows activity also towards tryptophan, aspartate and hydroxykinurenine

# Metabolic_Enzyme_26_Pathway:
map00300  Lysine biosynthesis;
 map00310  Lysine degradation

# Metabolic_Enzyme_26_Reaction:
L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate

# Metabolic_Enzyme_26_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_26_Signals:
None

# Metabolic_Enzyme_26_Transmembrane_Regions:
None

# Metabolic_Enzyme_26_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_26_EC_Link:
EC 2.6.1.7;EC 2.6.1.39

# Metabolic_Enzyme_26_GenBank_ID_Protein:
6165634

# Metabolic_Enzyme_26_SwissProt_ID:
AADAT_HUMAN (Q8N5Z0)

# Metabolic_Enzyme_26_swissprot_Name:
Not Available

# Metabolic_Enzyme_26_Genecard_id:
AADAT

# Metabolic_Enzyme_26_Geneatlas_id:
AADAT

# Metabolic_Enzyme_26_hgnc_id:
HGNC:17929

# Metabolic_Enzyme_26_PDB_ID:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_26_Subcellular_Location:
Mitochondrion (Potential)

# Metabolic_Enzyme_26_Gene_Sequence:
>1278 bp
ATGAATTACGCACGGTTCATCACGGCAGCGAGCGCAGCCAGAAACCCTTCTCCCATCCGG
ACCATGACTGACATATTGAGCAGAGGACCAAAATCGATGATCTCCTTGGCTGGTGGCTTA
CCAAATCCAAACATGTTTCCTTTTAAGACTGCCGTAATCACTGTAGAAAATGGAAAGACC
ATCCAATTTGGAGAAGAGATGATGAAGAGAGCACTTCAGTATTCTCCGAGTGCTGGAATT
CCAGAGCTTTTGTCCTGGCTAAAACAGTTACAAATAAAATTGCATAATCCTCCTACCATC
CATTACCCACCCAGTCAAGGACAAATGGATCTATGTGTCACATCTGGCAGCCAACAAGGT
CTTTGTAAGGTGTTTGAAATGATCATTAATCCTGGAGATAATGTCCTCCTAGATGAACCT
GCTTATTCAGGAACTCTTCAAAGTCTGCACCCACTGGGCTGCAACATTATTAATGTTGCC
AGTGATGAAAGTGGGATTGTTCCAGATTCCCTAAGAGACATACTTTCCAGATGGAAACCA
GAAGATGCAAAGAATCCCCAGAAAAACACCCCCAAATTTCTTTATACTGTTCCAAATGGC
AACAACCCTACTGGAAACTCATTAACCAGTGAACGCAAAAAGGAAATCTATGAGCTTGCA
AGAAAATATGATTTCCTCATAATAGAAGATGATCCTTACTATTTTCTCCAGTTTAACAAG
TTCAGGGTACCAACATTTCTTTCCATGGATGTTGATGGACGTGTCATCAGAGCTGACTCT
TTTTCAAAAATCATTTCCTCTGGGTTGAGAATAGGATTTTTAACTGGTCCAAAACCCTTA
ATAGAGAGAGTTATTTTACACATACAAGTTTCAACATTGCACCCCAGCACTTTTAACCAG
CTCATGATATCACAGCTTCTACACGAATGGGGAGAAGAAGGTTTCATGGCTCATGTAGAC
AGGGTTATTGATTTCTATAGTAACCAGAAGGATGCAATACTGGCAGCTGCAGACAAGTGG
TTAACTGGTTTGGCAGAATGGCATGTTCCTGCTGCTGGAATGTTTTTATGGATTAAAGTT
AAAGGCATTAATGATGTAAAAGAACTGATTGAAGAAAAGGCCGTTAAGATGGGGGTATTA
ATGCTCCCTGGAAATGCTTTCTACGTCGATAGCTCAGCTCCTAGCCCTTACTTGAGAGCA
TCCTTCTCTTCAGCTTCTCCAGAACAGATGGATGTGGCCTTCCAGGTATTAGCACAACTT
ATAAAAGAATCTTTATGA

# Metabolic_Enzyme_26_GenBank_ID_Gene:
AF097994

# Metabolic_Enzyme_26_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_26_Locus:
4q33

# Metabolic_Enzyme_26_SNPs:
rs12640652; rs716822; rs6553486; rs11735565; rs11728468; rs2466990; rs1585904; rs2279267; rs1480544; rs2727515; rs3796526; rs6854260; rs6854291; rs17711677; rs6855450; rs2054555; rs11722870; rs963660; rs11731427; rs2622068; rs6553487; rs17546531; rs10213032; rs2466991; rs12502235; rs17628883; rs2622066; rs13145318; rs2331802; rs11731442; rs4145964; rs991247; rs17628775; rs12502178; rs17546559; rs12511967; rs11939395; rs2622069; rs3076683; rs17055413; rs2331801; rs2955255; rs2928819; rs17852900; rs34588185; rs34202278; rs1118262; rs1585903; rs36017064; rs11732763; rs3214945; rs35249526; rs35100741; rs34354891; rs13112109; rs13114656; rs34871790; rs34834671; rs2331804; rs41278617; rs2727516; rs34599867; rs35095178; rs3076682; rs5864015; rs35756932; rs35967487; rs2622071; rs35495254; rs28779786; rs28480175; rs28629414; rs35569089; rs35644368; rs991245; rs35614821; rs35692808; rs36050852; rs13131755; rs2331805; rs2331803; rs2622070; rs35087238; rs34877246; rs35289623; rs35560170; rs13117677; rs35585412; rs4692791; rs2928820; rs34839999; rs36038700; rs4692790; rs35866167; rs12650424; rs1351399; rs17628895; rs2622074; rs2727523; rs2727526; rs2955256; rs34642369; rs34643472; rs4692788

# Metabolic_Enzyme_26_General_References:
Not Available

# Metabolic_Enzyme_26_References:
Not Available

# Metabolic_Enzyme_27_ID:
5637

# Metabolic_Enzyme_27_Name:
Ornithine aminotransferase, mitochondrial precursor

# Metabolic_Enzyme_27_Synonyms:
Ornithine--oxo-acid aminotransferase[Contains: Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form]

# Metabolic_Enzyme_27_Gene_Name:
OAT

# Metabolic_Enzyme_27_Protein_Sequence:
>Ornithine aminotransferase, mitochondrial precursor
MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPV
ALERGKGIYL
WDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNV
LGEYEEYITKLFNYHKVLPMN
TGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFW
GRTLSAISSSTDPTSYDGFGPFMPGFDIIPYN
DLPALERALQDPNVAAFMVEPIQGEAG
VVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDY
ENVRPDIVLLGKALSG
GLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENAD
KLGII
LRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFA
PPLVI
KEDELRESIEIINKTILSF

# Metabolic_Enzyme_27_Number_of_Residues:
439

# Metabolic_Enzyme_27_Molecular_Weight:
48535

# Metabolic_Enzyme_27_Theoretical_pI:
7.05

# Metabolic_Enzyme_27_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_27_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_27_Specific_Function:
L-ornithine + a 2-oxo acid = L-glutamate 5- semialdehyde + an L-amino acid

# Metabolic_Enzyme_27_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_27_Reaction:
L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid

# Metabolic_Enzyme_27_Pfam_Domain_Function:
PF00202:Aminotran_3

# Metabolic_Enzyme_27_Signals:
1-20

# Metabolic_Enzyme_27_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_27_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_27_EC_Link:
EC 2.6.1.13

# Metabolic_Enzyme_27_GenBank_ID_Protein:
189329

# Metabolic_Enzyme_27_SwissProt_ID:
OAT_HUMAN (P04181)

# Metabolic_Enzyme_27_swissprot_Name:
Not Available

# Metabolic_Enzyme_27_Genecard_id:
OAT

# Metabolic_Enzyme_27_Geneatlas_id:
OAT

# Metabolic_Enzyme_27_hgnc_id:
HGNC:8091

# Metabolic_Enzyme_27_PDB_ID:
1OAT

# Metabolic_Enzyme_27_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_27_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_27_Gene_Sequence:
>1320 bp

ATGTTTTCCAAACTAGCACATTTGCAGAGGTTTGCTGTACTTAGTCGCGGAGTTCATTC
TTCAGTGGCTT
CTGCTACATCTGTTGCAACTAAAAAAACAGTCCAAGGCCCTCCAACCT
CTGATGACATTTTTGAAAGGGA
ATATAAGTATGGTGCACACAACTACCATCCTTTACCT
GTAGCCCTGGAGAGAGGAAAAGGTATTTACTTA
TGGGATGTAGAAGGCAGAAAATATTT
TGACTTCCTGAGTTCTTACAGTGCTGTCAACCAAGGGCATTGTC
ACCCCAAGATTGTGA
ATGCTCTGAAGAGTCAAGTGGACAAATTGACCTTAACATCTAGAGCTTTCTATAA
TAAC
GTACTTGGTGAATATGAGGAGTATATTACTAAACTTTTCAACTACCACAAAGTTCTTCCT
ATGAAT
ACAGGAGTGGAGGCTGGAGAGACTGCCTGTAAACTAGCTCGTAAGTGGGGCTA
TACCGTGAAGGGCATTC
AGAAATACAAAGCAAAGATTGTTTTTGCAGCTGGGAACTTCT
GGGGTAGGACGTTGTCTGCTATCTCCAG
TTCCACAGACCCAACCAGTTACGATGGTTTT
GGACCATTTATGCCGGGATTCGACATCATTCCCTATAAT
GATCTGCCCGCACTGGAGCG
TGCTCTTCAGGATCCAAATGTGGCTGCGTTCATGGTAGAACCAATTCAGG
GTGAAGCAG
GCGTTGTTGTTCCGGATCCAGGTTACCTAATGGGAGTGCGAGAGCTCTGCACCAGGCACC
A
GGTTCTCTTTATTGCTGATGAAATACAGACAGGATTGGCCAGAACTGGTAGATGGCTG
GCTGTTGATTAT
GAAAATGTCAGACCTGATATAGTCCTCCTTGGAAAGGCCCTTTCTGG
GGGCTTATACCCTGTGTCTGCAG
TGCTGTGTGATGATGACATCATGCTGACCATTAAGC
CAGGGGAGCATGGGTCCACATACGGTGGCAATCC
ACTAGGCTGCCGAGTGGCCATCGCA
GCCCTTGAGGTTTTAGAAGAAGAAAACCTTGCTGAAAATGCAGAC
AAATTGGGCATTAT
CTTGAGAAATGAACTCATGAAGCTACCTTCTGATGTTGTAACTGCCGTAAGAGGAA
AAG
GATTATTAAACGCTATTGTCATTAAAGAAACCAAAGATTGGGATGCTTGGAAGGTGTGTC
TACGACT
TCGAGATAATGGACTTCTGGCCAAGCCAACCCATGGCGACATTATCAGGTTT
GCGCCTCCGCTGGTGATC
AAGGAGGATGAGCTTCGAGAGTCCATTGAAATTATTAACAA
GACCATCTTGTCTTTCTGA

# Metabolic_Enzyme_27_GenBank_ID_Gene:
M12267

# Metabolic_Enzyme_27_Chromosome_Location:
Not Available

# Metabolic_Enzyme_27_Locus:
Not Available

# Metabolic_Enzyme_27_SNPs:
Not Available

# Metabolic_Enzyme_27_General_References:
3456579; 3816496; 2507357; 3170546; 2373169; 1682785; 3754226; 9309222; 9514741; 9878407; 3375240; 2793865; 1612597; 1737786; 7887415; 7668253

# Metabolic_Enzyme_27_References:
Not Available

# Metabolic_Enzyme_28_ID:
5864

# Metabolic_Enzyme_28_Name:
GMP synthase [glutamine-hydrolyzing]

# Metabolic_Enzyme_28_Synonyms:
Glutamine amidotransferase; GMP synthetase

# Metabolic_Enzyme_28_Gene_Name:
GMPS

# Metabolic_Enzyme_28_Protein_Sequence:
>GMP synthase glutaminehydrolyzing
MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETP
AFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHK
KSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANE
SKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVL
VLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAA
HSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPE
EVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVR
ILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPH
TLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDW
ESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILR
ESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVE
VVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE

# Metabolic_Enzyme_28_Number_of_Residues:
693

# Metabolic_Enzyme_28_Molecular_Weight:
76716

# Metabolic_Enzyme_28_Theoretical_pI:
6.86

# Metabolic_Enzyme_28_GO_Classification:
>>>
Function:  GMP synthase (glutamine-hydrolyzing) activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Function:  GMP synthase (glutamine-hydrolyzing) activity
Function:  molecular function unknown
Function:  catalytic activity
 ||
>>>
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
Process:  GMP biosynthesis
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_28_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_28_Specific_Function:
Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division

# Metabolic_Enzyme_28_Pathway:
map00230  Purine metabolism;
 map00251  Glutamate metabolism

# Metabolic_Enzyme_28_Reaction:
ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate

# Metabolic_Enzyme_28_Pfam_Domain_Function:
PF06508:ExsB;
PF00117:GATase;
PF00958:GMP_synt_C

# Metabolic_Enzyme_28_Signals:
None

# Metabolic_Enzyme_28_Transmembrane_Regions:
None

# Metabolic_Enzyme_28_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_28_EC_Link:
EC 6.3.5.2

# Metabolic_Enzyme_28_GenBank_ID_Protein:
595410

# Metabolic_Enzyme_28_SwissProt_ID:
GUAA_HUMAN (P49915)

# Metabolic_Enzyme_28_swissprot_Name:
Not Available

# Metabolic_Enzyme_28_Genecard_id:
GMPS

# Metabolic_Enzyme_28_Geneatlas_id:
GMPS

# Metabolic_Enzyme_28_hgnc_id:
HGNC:4378

# Metabolic_Enzyme_28_PDB_ID:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_28_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_28_Gene_Sequence:
>2082 bp
ATGGCTCTGTGCAACGGAGACTCCAAGCTGGAGAATGCTGGAGGAGACCTTAAGGATGGC
CACCACCACTATGAAGGAGCTGTTGTCATTCTGGATGCTGGTGCTCAGTACGGGAAAGTC
ATAGACCGAAGAGTGAGGGAACTGTTCGTGCAGTCTGAAATTTTCCCCTTGGAAACACCA
GCATTTGCTATAAAGGAACAAGGATTCCGTGCTATTATCATCTCTGGAGGACCTAATTCT
GTGTATGCTGAAGATGCTCCCTGGTTTGATCCAGCAATATTCACTATTGGCAAGCCTGTT
CTTGGAATTTGCTATGGTATGCAGATGATGAATAAGGTATTTGGAGGTACTGTGCACAAA
AAAAGTGTCAGAGAAGATGGAGTTTTCAACATTAGTGTGGATAATACATGTTCATTATTC
AGGGGCCTTCAGAAGGAAGAAGTTGTTTTGCTTACACATGGAGATAGTGTAGACAAAGTA
GCTGATGGATTCAAGGTTGTGGCACGTTCTGGAAACATAGTAGCAGGCATAGCAAATGAA
TCTAAAAAGTTATATGGAGCACAGTTCCACCCTGAAGTTGGCCTTACAGAAAATGGAAAA
GTAATACTGAAGAATTTCCTTTATGATATAGCTGGATGCAGTGGAACCTTCACCGTGCAG
AACAGAGAACTTGAGTGTATTCGAGAGATCAAAGAGAGAGTAGGCACGTCAAAAGTTTTG
GTTTTACTCAGTGGTGGAGTAGACTCAACAGTTTGTACAGCTTTGCTAAATCGTGCTTTG
AACCAAGAACAAGTCATTGCTGTGCACATTGATAATGGCTTTATGAGAAAACGAGAAAGC
CAGTCTGTTGAAGAGGCCCTCAAAAAGCTTGGAATTCAGGTCAAAGTGATAAATGCTGCT
CATTCTTTCTACAATGGAACAACAACCCTACCAATATCAGATGAAGATAGAACCCCACGG
AAAAGAATTAGCAAAACGTTAAATATGACCACAAGTCCTGAAGAGAAAAGAAAAATCATT
GGGGATACTTTTGTTAAGATTGCCAATGAAGTAATTGGAGAAATGAACTTGAAACCAGAG
GAGGTTTTCCTTGCCCAAGGTACTTTACGGCCTGATCTAATTGAAAGTGCATCCCTTGTT
GCAAGTGGCAAAGCTGAACTCATCAAAACCCATCACAATGACACAGAGCTCATCAGAAAG
TTGAGAGAGGAGGGAAAAGTAATAGAACCTCTGAAAGATTTTCATAAAGATGAAGTGAGA
ATTTTGGGCAGAGAACTTGGACTTCCAGAAGAGTTAGTTTCCAGGCATCCATTTCCAGGT
CCTGGCCTGGCAATCAGAGTAATATGTGCTGAAGAACCTTATATTTGTAAGGACTTTCCT
GAAACCAACAATATTTTGAAAATAGTAGCTGATTTTTCTGCAAGTGTTAAAAAGCCACAT
ACCCTATTACAGAGAGTCAAAGCCTGCACAACAGAAGAGGATCAGGAGAAGCTGATGCAA
ATTACCAGTCTGCATTCACTGAATGCCTTCTTGCTGCCAATTAAAACTGTAGGTGTGCAG
GGTGACTGTCGTTCCTACAGTTACGTGTGTGGAATCTCCAGTAAAGATGAACCTGACTGG
GAATCACTTATTTTTCTGGCTAGGCTTATACCTCGCATGTGTCACAACGTTAACAGAGTT
GTTTATATATTTGGCCCACCAGTTAAAGAACCTCCTACAGATGTTACTCCCACTTTCTTG
ACAACAGGGGTGCTCAGTACTTTACGCCAAGCTGATTTTGAGGCCCATAACATTCTCAGG
GAGTCTGGGTATGCTGGGAAAATCAGCCAGATGCCGGTGATTTTGACACCATTACATTTT
GATCGGGACCCACTTCAAAAGCAGCCTTCATGCCAGAGATCTGTGGTTATTCGAACCTTT
ATTACTAGTGACTTCATGACTGGTATACCTGCAACACCTGGCAATGAGATCCCTGTAGAG
GTGGTATTAAAGATGGTCACTGAGATTAAGAAGATTCCTGGTATTTCTCGAATTATGTAT
GACTTAACATCAAAGCCCCCAGGAACTACTGAGTGGGAGTAA

# Metabolic_Enzyme_28_GenBank_ID_Gene:
U10860

# Metabolic_Enzyme_28_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_28_Locus:
3q24

# Metabolic_Enzyme_28_SNPs:
rs7637292; rs10936021; rs12496896; rs12634592; rs4680220; rs401514; rs7617878; rs4108611; rs3772117; rs7615287; rs7636930; rs6441023; rs4679757; rs2067877; rs6766927; rs12491178; rs1356252; rs7633168; rs6799267; rs12493764; rs3821365; rs6441028; rs9825321; rs2320318; rs12489430; rs7619976; rs6441027; rs12491537; rs6775044; rs7643525; rs12494730; rs6441024; rs6806109; rs6441026; rs12634282; rs12492258; rs3772116; rs6441022; rs6797289; rs7651038; rs12636569; rs2068601; rs9882341; rs3772112; rs10804774; rs12490114; rs11716272; rs12638836; rs4679756; rs406701; rs7430851; rs12497968; rs9883153; rs3772115; rs9819269; rs11712694; rs12495418; rs2874232; rs410042; rs9820541; rs6800992; rs7652005; rs6441025; rs11714133; rs9820534; rs6791517; rs3732399; rs12485735; rs10804773; rs12493422; rs12494104; rs12496313; rs1878213; rs9840456; rs13060931; rs7650106; rs1878211; rs12496006; rs3772113; rs10936020; rs9868194; rs12491896; rs11706359; rs6777776; rs35910218; rs11547948; rs35848656; rs11915364; rs34537819; rs28438758; rs12107883; rs13324534; rs35759331; rs12386360; rs386067; rs445758; rs35973380; rs4680221; rs12386362; rs35962523; rs35285447; rs11334499; rs35811525; rs13327285; rs10640770; rs6768724; rs7633729; rs12386359; rs4399846; rs3772114; rs35321137; rs34337666; rs7620397; rs35275341; rs12633671; rs33927918; rs11437800; rs35876194; rs35954197; rs9855091; rs35651046; rs35140614; rs4057812; rs34658682; rs35475067; rs9631467; rs35494199; rs9846097; rs13061643; rs9862051; rs35510283; rs34118890; rs35377438; rs11716666; rs36101569; rs35285525; rs12497735; rs34117696; rs34290186; rs34712245; rs34327298; rs35833112; rs35357023; rs41267913; rs35724165; rs12638792; rs35031753; rs34182099; rs11430855; rs1878212; rs12486102; rs10691429; rs9864005; rs35664957; rs11425774; rs34609350; rs10548751; rs7625201; rs36079607; rs7645121; rs7620712; rs12493409; rs10704428; rs35628034; rs9832621; rs7428956; rs4680219; rs34125997; rs28655132; rs35440885; rs34101828; rs4383470; rs12633670; rs11391424; rs5853733; rs11410318; rs35247619; rs35984925; rs12486189; rs35552128; rs35402685; rs10613824; rs11411886; rs35667159; rs5853732; rs35386649; rs33978589; rs12485698; rs12485701; rs12485742; rs12485802; rs12486864; rs12488351; rs12493934; rs12493963; rs12494143; rs12497838; rs1533443; rs16825554; rs2063903; rs2292716; rs4679758; rs4680222; rs819846

# Metabolic_Enzyme_28_General_References:
8089153

# Metabolic_Enzyme_28_References:
Not Available

# Metabolic_Enzyme_29_ID:
5316

# Metabolic_Enzyme_29_Name:
Thymidylate synthase

# Metabolic_Enzyme_29_Synonyms:
TS; TSase

# Metabolic_Enzyme_29_Gene_Name:
TYMS

# Metabolic_Enzyme_29_Protein_Sequence:
>Thymidylate synthase
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDE
FPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLD
SLGFSTREEGDLGPVYGFQWR
HFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRII
MCAWNPRDLPLMALPPCHALCQFYVVNSELSC
QLYQRSGDMGLGVPFNIASYALLTYMI
AHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLR
ILRKVEKIDDFKAEDF
QIEGYNPHPTIKMEMAV

# Metabolic_Enzyme_29_Number_of_Residues:
313

# Metabolic_Enzyme_29_Molecular_Weight:
35716

# Metabolic_Enzyme_29_Theoretical_pI:
7.00

# Metabolic_Enzyme_29_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  5,10-methylenetetrahydrofolate-dependent methyltransferase activity
Function:  thymidylate synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  pyrimidine nucleotide metabolism
Process:  pyrimidine nucleotide biosynthesis
Process:  pyrimidine nucleoside monophosphate biosynthesis
Process:  pyrimidine deoxyribonucleoside monophosphate biosynthesis
Process:  dTMP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_29_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_29_Specific_Function:
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP

# Metabolic_Enzyme_29_Pathway:
map00240  Pyrimidine metabolism;
 map00670  One carbon pool by folate

# Metabolic_Enzyme_29_Reaction:
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP

# Metabolic_Enzyme_29_Pfam_Domain_Function:
PF00303:Thymidylat_synt

# Metabolic_Enzyme_29_Signals:
None

# Metabolic_Enzyme_29_Transmembrane_Regions:
None

# Metabolic_Enzyme_29_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_29_EC_Link:
EC 2.1.1.45

# Metabolic_Enzyme_29_GenBank_ID_Protein:
37479

# Metabolic_Enzyme_29_SwissProt_ID:
TYSY_HUMAN (P04818)

# Metabolic_Enzyme_29_swissprot_Name:
Not Available

# Metabolic_Enzyme_29_Genecard_id:
TYMS

# Metabolic_Enzyme_29_Geneatlas_id:
TYMS

# Metabolic_Enzyme_29_hgnc_id:
HGNC:12441

# Metabolic_Enzyme_29_PDB_ID:
1JUJ

# Metabolic_Enzyme_29_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_29_Subcellular_Location:
Not Available

# Metabolic_Enzyme_29_Gene_Sequence:
>942 bp

ATGCCTGTGGCCGGCTCGGAGCTGCCGCGCCGGCCCTTGCCCCCCGCCGCACAGGAGCG
GGACGCCGAGC
CGCGTCCGCCGCACGGGGAGCTGCAGTACCTGGGGCAGATCCAACACA
TCCTCCGCTGCGGCGTCAGGAA
GGACGACCGCACGGGCACCGGCACCCTGTCGGTATTC
GGCATGCAGGCGCGCTACAGCCTGAGAGATGAA
TTCCCTCTGCTGACAACCAAACGTGT
GTTCTGGAAGGGTGTTTTGGAGGAGTTGCTGTGGTTTATCAAGG
GATCCACAAATGCTA
AAGAGCTGTCTTCCAAGGGAGTGAAAATCTGGGATGCCAATGGATCCCGAGACTT
TTTG
GACAGCCTGGGATTCTCCACCAGAGAAGAAGGGGACTTGGGCCCAGTTTATGGCTTCCAG
TGGAGG
CATTTTGGGGCAGAATACAGAGATATGGAATCAGATTATTCAGGACAGGGAGT
TGACCAACTGCAAAGAG
TGATTGACACCATCAAAACCAACCCTGACGACAGAAGAATCA
TCATGTGCGCTTGGAATCCAAGAGATCT
TCCTCTGATGGCGCTGCCTCCATGCCATGCC
CTCTGCCAGTTCTATGTGGTGAACAGTGAGCTGTCCTGC
CAGCTGTACCAGAGATCGGG
AGACATGGGCCTCGGTGTGCCTTTCAACATCGCCAGCTACGCCCTGCTCA
CGTACATGA
TTGCGCACATCACGGGCCTGAAGCCAGGTGACTTTATACACACTTTGGGAGATGCACATA
T
TTACCTGAATCACATCGAGCCACTGAAAATTCAGCTTCAGCGAGAACCCAGACCTTTC
CCAAAGCTCAGG
ATTCTTCGAAAAGTTGAGAAAATTGATGACTTCAAAGCTGAAGACTT
TCAGATTGAAGGGTACAATCCGC
ATCCAACTATTAAAATGGAAATGGCTGTTTAG

# Metabolic_Enzyme_29_GenBank_ID_Gene:
X02308

# Metabolic_Enzyme_29_Chromosome_Location:
Chromosome:18

# Metabolic_Enzyme_29_Locus:
18p11.32

# Metabolic_Enzyme_29_SNPs:
rs3786362; rs16948421; rs699517; rs16948409; rs2790; rs2612098; rs2853740; rs2612100; rs1001761; rs2847149; rs2853532; rs2853536; rs2244500; rs2612099; rs2853543; rs11873890; rs1004474; rs2612096; rs1059394; rs16948305; rs9953447; rs2847609; rs2847150; rs1051527; rs8088781; rs2612095; rs1059393; rs3826626; rs15872; rs2853524; rs2853537; rs16948322; rs34795969; rs2847151; rs1970763; rs2853528; rs2853535; rs2606245; rs2853525; rs2853534; rs2847153; rs35143366; rs11876369; rs2853526; rs8094124; rs35069638; rs2925470; rs2015944; rs2853527; rs36005458; rs35517586; rs35449827; rs35710611; rs36080427; rs34502878; rs34007153; rs523998; rs11540152; rs596909; rs11540153; rs2847608; rs34543484; rs287599; rs571276; rs188267; rs1134333; rs2853531; rs11872109; rs172296; rs2853540; rs2853541; rs34118802; rs11875638; rs287600; rs2124616; rs2853530; rs11872105; rs35087169; rs9675762; rs1134338; rs12958458; rs11875614; rs2853739; rs35914751; rs287601; rs1894234; rs35626549; rs2853538; rs1894233; rs12962403; rs287602; rs1672564; rs1134335; rs35338895; rs2606244; rs8093444; rs2847610; rs35723992; rs207950; rs11878085; rs36009852; rs2853529; rs28503425; rs12326481; rs34581442; rs207949; rs571377; rs8084452; rs35623440; rs34941278; rs1672569; rs2606243; rs2606242; rs644072; rs2926562; rs2847611; rs11874511; rs11411741; rs11875662; rs10502289; rs10502290; rs1058151; rs1059384; rs11081251; rs11081266; rs11664283; rs11873007; rs11876755; rs11877806; rs12373391; rs12964837; rs2276115; rs2298581; rs2298582; rs2298583; rs2606241; rs2606246; rs2612092; rs2741182; rs2741183; rs2741184; rs2741186; rs2847173; rs2847324; rs2847326; rs2847607; rs2847612; rs2847620; rs2853533; rs2853741; rs2853742; rs3198762; rs34445332; rs35173059; rs3744962; rs3786355; rs3819101; rs3819102; rs495139; rs502396; rs539913; rs548203; rs579099; rs686819; rs7229142; rs7239738; rs8089075; rs8423; rs9948583; rs9966612

# Metabolic_Enzyme_29_General_References:
2987839; 2243092; 2532645; 3839505; 2656695; 8845352; 11329255; 11278511

# Metabolic_Enzyme_29_References:
Not Available

# Metabolic_Enzyme_30_ID:
5759

# Metabolic_Enzyme_30_Name:
Glutamate--cysteine ligase catalytic subunit

# Metabolic_Enzyme_30_Synonyms:
Gamma- glutamylcysteine synthetase; Gamma-ECS; GCS heavy chain

# Metabolic_Enzyme_30_Gene_Name:
GCLC

# Metabolic_Enzyme_30_Protein_Sequence:
>Glutamatecysteine ligase catalytic subunit
MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQ
EGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
QGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNS
YLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYS
LILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN

# Metabolic_Enzyme_30_Number_of_Residues:
637

# Metabolic_Enzyme_30_Molecular_Weight:
72767

# Metabolic_Enzyme_30_Theoretical_pI:
5.98

# Metabolic_Enzyme_30_GO_Classification:
>>>
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  acid-amino acid ligase activity
Function:  glutamate-cysteine ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  cofactor metabolism
Process:  coenzyme metabolism
Process:  glutathione metabolism
Process:  glutathione biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_30_General_Function:
Not Available

# Metabolic_Enzyme_30_Specific_Function:
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

# Metabolic_Enzyme_30_Pathway:
map00251  Glutamate metabolism;
 map00480  Glutathione metabolism

# Metabolic_Enzyme_30_Reaction:
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

# Metabolic_Enzyme_30_Pfam_Domain_Function:
PF03074:GCS

# Metabolic_Enzyme_30_Signals:
None

# Metabolic_Enzyme_30_Transmembrane_Regions:
None

# Metabolic_Enzyme_30_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_30_EC_Link:
EC 6.3.2.2

# Metabolic_Enzyme_30_GenBank_ID_Protein:
183039

# Metabolic_Enzyme_30_SwissProt_ID:
GSH1_HUMAN (P48506)

# Metabolic_Enzyme_30_swissprot_Name:
Not Available

# Metabolic_Enzyme_30_Genecard_id:
GCLC

# Metabolic_Enzyme_30_Geneatlas_id:
GCLC

# Metabolic_Enzyme_30_hgnc_id:
HGNC:4311

# Metabolic_Enzyme_30_PDB_ID:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_30_Subcellular_Location:
Not Available

# Metabolic_Enzyme_30_Gene_Sequence:
>1914 bp
ATGGGGCTGCTGTCCCAGGGCTCGCCGCTGAGCTGGGAGGAAACCAAGCGCCATGCCGAC
CACGTGCGGCGGCACGGGATCCTCCAGTTCCTGCACATCTACCACGCCGTCAAGGACCGG
CACAAGGACGTTCTCAAGTGGGGCGATGAGGTGGAATACATGTTGGTATCTTTTGATCAT
GAAAATAAAAAAGTCCGGTTGGTCCTGTCTGGGGAGAAAGTTCTTGAAACTCTGCAAGAG
AAGGGGGAAAGGACAAACCCAAACCATCCTACCCTTTGGAGACCAGAGTATGGGAGTTAC
ATGATTGAAGGGACACCAGGACAGCCCTACGGAGGAACAATGTCCGAGTTCAATACAGTT
GAGGCCAACATGCGAAAACGCCGGAAGGAGGCTACTTCTATATTAGAAGAAAATCAGGCT
CTTTGCACAATAACTTCATTTCCCAGATTAGGCTGTCCTGGGTTCACACTGCCCGAGGTC
AAACCCAACCCAGTGGAAGGAGGAGCTTCCAAGTCCCTCTTCTTTCCAGATGAAGCAATA
AACAAGCACCCTCGCTTCAGTACCTTAACAAGAAATATCCGACATAGGAGAGGAGAAAAG
GTTGTCATCAATGTACCAATATTTAAGGACAAGAATACACCATCTCCATTTATAGAAACA
TTTACTGAGGATGATGAAGCTTCAAGGGCTTCTAAGCCGGATCATATTTACATGGATGCC
ATGGGATTTGGAATGGGCAATTGCTGTCTCCAGGTGACATTCCAAGCCTGCAGTATATCT
GAGGCCAGATACCTTTATGATCAGTTGGCTACTATCTGTCCAATTGTTATGGCTTTGAGT
GCTGCATCTCCCTTTTACCGAGGCTATGTGTCAGACATTGATTGTCGCTGGGGAGTGATT
TCTGCATCTGTAGATGATAGAACTCGGGAGGAGCGAGGACTGGAGCCATTGAAGAACAAT
AACTATAGGATCAGTAAATCCCGATATGACTCAATAGACAGCTATTTATCTAAGTGTGGT
GAGAAATATAATGACATCGACTTGACGATAGATAAAGAGATCTACGAACAGCTGTTGCAG
GAAGGCATTGATCATCTCCTGGCCCAGCATGTTGCTCATCTCTTTATTAGAGACCCACTG
ACACTGTTTGAAGAGAAAATACACCTGGATGATGCTAATGAGTCTGACCATTTTGAGAAT
ATTCAGTCCACAAATTGGCAGACAATGAGATTTAAGCCCCCTCCTCCAAACTCAGACATT
GGATGGAGAGTAGAATTTCGACCCATGGAGGTGCAATTAACAGACTTTGAGAACTCTGCC
TATGTGGTGTTTGTGGTACTGCTCACCAGAGTGATCCTTTCCTACAAATTGGATTTTCTC
ATTCCACTGTCAAAGGTTGATGAGAACATGAAGGTAGCACAGAAAAGAGATGCTGTCTTG
CAGGGAATGTTTTATTTCAGGAAAGATATTTGCAAAGGTGGCAATGCAGTGGTGGATGGT
TGTGGCAAGGCCCAGAACAGCACGGAGCTCGCTGCAGAGGAGTACACCCTCATGAGCATA
GACACCATCATCAATGGGAAGGAAGGTGTGTTTCCTGGACTGATCCCAATTCTGAACTCT
TACCTTGAAAACATGGAAGTGGATGTGGACACCAGATGTAGTATTCTGAACTACCTAAAG
CTAATTAAGAAGAGAGCATCTGGAGAACTAATGACAGTTGCCAGATGGATGAGGGAGTTT
ATCGCAAACCATCCTGACTACAAGCAAGACAGTGTCATAACTGATGAAATGAATTATAGC
CTTATTTTGAAGTGTAACCAAATTGCAAATGAATTATGTGAATGCCCAGAGTTACTTGGA
TCAGCATTTAGGAAAGTAAAATATAGTGGAAGTAAAACTGACTCATCCAACTAG

# Metabolic_Enzyme_30_GenBank_ID_Gene:
M90656

# Metabolic_Enzyme_30_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_30_Locus:
6p12

# Metabolic_Enzyme_30_SNPs:
Not Available

# Metabolic_Enzyme_30_General_References:
1350904; 14574404; 7726839; 10515893; 10733484

# Metabolic_Enzyme_30_References:
Not Available

# Metabolic_Enzyme_31_ID:
6134

# Metabolic_Enzyme_31_Name:
Phosphoribosylformylglycinamidine synthase

# Metabolic_Enzyme_31_Synonyms:
FGAM synthase; FGAMS; Formylglycinamide ribotide amidotransferase; FGARAT; Formylglycinamide ribotide synthetase

# Metabolic_Enzyme_31_Gene_Name:
PFAS

# Metabolic_Enzyme_31_Protein_Sequence:
>Phosphoribosylformylglycinamidine synthase
MSPVLHFYVRPSGHEGAASGHTRRKLQGKLPELQGVETELCYNVNWTAEALPSAEETKKL
MWLFGCPLLLDDVARESWLLPGSNDLLLEVGPRLNFSTPTSTNIVSVCRATGLGPVDRVE
TTRRYRLSFAHPPSAEVEAIALATLHDRMTEQHFPHPIQSFSPESMPEPLNGPINILGEG
RLALEKANQELGLALDSWDLDFYTKRFQELQRNPSTVEAFDLAQSNSEHSRHWFFKGQLH
VDGQKLVHSLFESIMSTQESSNPNNVLKFCDNSSAIQGKEVRFLRPEDPTRPSRFQQQQG
LRHVVFTAETHNFPTGVCPFSGATTGTGGRIRDVQCTGRGAHVVAGTAGYCFGNLHIPGY
NLPWEDLSFQYPGNFARPLEVAIEASNGASDYGNKFGEPVLAGFARSLGLQLPDGQRREW
IKPIMFSGGIGSMEADHISKEAPEPGMEVVKVGGPVYRIGVGGGAASSVQVQGDNTSDLD
FGAVQRGDPEMEQKMNRVIRACVEAPKGNPICSLHDQGAGGNGNVLKELSDPAGAIIYTS
RFQLGDPTLNALEIWGAEYQESNALLLRSPNRDFLTHVSARERCPACFVGTITGDRRIVL
VDDRECPVRRNGQGDAPPTPPPTPVDLELEWVLGKMPRKEFFLQRKPPMLQPLALPPGLS
VHQALERVLRLPAVASKRYLTNKVDRSVGGLVAQQQCVGPLQTPLADVAVVALSHEELIG
AATALGEQPVKSLLDPKVAARLAVAEALTNLVFALVTDLRDVKCSGNWMWAAKLPGEGAA
LADACEAMVAVMAALGVAVDGGKDSLSMAARVGTETVRAPGSLVISAYAVCPDITATVTP
DLKHPEGRGHLLYVALSPGQHRLGGTALAQCFSQLGEHPPDLDLPENLVRAFSITQGLLK
DRLLCSGHDVSDGGLVTCLLEMAFAGNCGLQVDVPVPRVDVLSVLFAEEPGLVLEVQEPD
LAQVLKRYRDAGLHCLELGHTGEAGPHAMVRVSVNGAVVLEEPVGELRALWEETSFQLDR
LQAEPRCVAEEERGLRERMGPSYCLPPTFPKASVPREPGGPSPRVAILREEGSNGDREMA
DAFHLAGFEVWDVTMQDLCSGAIGLDTFRGVAFVGGFSYADVLGSAKGWAAAVTFHPRAG
AELRRFRKRPDTFSLGVCNGCQLLALLGWVGGDPNEDAAEMGPDSQPARPGLLLRHNLSG
RYESRWASVRVGPGPALMLRGMEGAVLPVWSAHGEGYVAFSSPELQAQIEARGLAPLHWA
DDDGNPTEQYPLNPNGSPGGVAGICSCDGRHLAVMPHPERAVRPWQWAWRPPPFDTLTTS
PWLQLSINARNWTLEGSC

# Metabolic_Enzyme_31_Number_of_Residues:
1338

# Metabolic_Enzyme_31_Molecular_Weight:
144666

# Metabolic_Enzyme_31_Theoretical_pI:
5.55

# Metabolic_Enzyme_31_GO_Classification:
>>>
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Function:  phosphoribosylformylglycinamidine synthase activity
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
Process:  IMP biosynthesis
Process:  'de novo' IMP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_31_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_31_Specific_Function:
ATP + 2-N-formyl-1-N-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-1-N-(5-phospho-D-ribosyl)acetamidine + L-glutamate

# Metabolic_Enzyme_31_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_31_Reaction:
ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate

# Metabolic_Enzyme_31_Pfam_Domain_Function:
PF00586:AIRS;
PF02769:AIRS_C

# Metabolic_Enzyme_31_Signals:
None

# Metabolic_Enzyme_31_Transmembrane_Regions:
None

# Metabolic_Enzyme_31_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_31_EC_Link:
EC 6.3.5.3

# Metabolic_Enzyme_31_GenBank_ID_Protein:
2224663

# Metabolic_Enzyme_31_SwissProt_ID:
PUR4_HUMAN (O15067)

# Metabolic_Enzyme_31_swissprot_Name:
Not Available

# Metabolic_Enzyme_31_Genecard_id:
PFAS

# Metabolic_Enzyme_31_Geneatlas_id:
PFAS

# Metabolic_Enzyme_31_hgnc_id:
HGNC:8863

# Metabolic_Enzyme_31_PDB_ID:
Not Available

# Metabolic_Enzyme_31_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_31_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_31_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_31_Gene_Sequence:
>4117 bp
GGCCGCGAGTGCATCTTCCACGAACCTAATTCATCTCTCCAGCAAAGGACACATCTCTCC
AGCAAAGGACACCTCTCTCCAGCAAAGGACACCTGCAGAGATGTCCCCAGTCCTTCACTT
CTATGTTCGTCCCTCTGGCCATGAGGGGGCAGCCTCTGGACACACTCGGAGGAAACTGCA
AGGGAAACTGCCAGAGCTGCAGGGCGTCGAGACTGAACTGTGCTACAACGTGAACTGGAC
AGCTGAGGCCCTCCCCAGTGCTGAGGAGACAAAGAAGCTGATGTGGCTGTTTGGTTGCCC
CTTACTGCTGGATGATGTTGCTCGGGAGTCCTGGCTCCTTCCTGGCTCCAATGACCTGCT
GCTGGAGGTCGGGCCCAGGCTGAACTTCTCCACCCCAACATCCACCAACATCGTGTCAGT
GTGCCGCGCCACTGGGCTGGGGCCTGTGGATCGTGTGGAGACCACCCGGCGCTACCGGCT
CTCGTTTGCCCACCCCCCGTCAGCTGAGGTGGAAGCCATTGCTCTGGCTACCCTGCACGA
CCGGATGACAGAGCAGCACTTCCCCCATCCCATCCAGAGTTTCTCCCCTGAGAGCATGCC
GGAACCCCTCAATGGCCCTATCAATATACTGGGTGAGGGCCGGCTTGCGCTGGAGAAGGC
CAACCAGGAGCTTGGTCTGGCTTTAGACTCTTGGGACCTAGACTTCTACACCAAGCGCTT
CCAGGAGCTACAGCGGAACCCGAGCACTGTGGAGGCCTTTGACTTGGCGCAGTCCAATAG
CGAGCACAGCCGACACTGGTTCTTCAAGGGCCAGCTCCACGTGGATGGGCAGAAGCTGGT
GCACTCACTGTTTGAGTCCATCATGAGCACCCAGGAATCCTCGAACCCCAACAACGTCCT
CAAATTCTGTGATAACAGCAGTGCAATCCAGGGAAAGGAAGTCCGATTCCTACGGCCTGA
GGACCCCACACGGCCAAGCCGCTTCCAGCAACAGCAAGGGCTGAGACATGTTGTCTTCAC
AGCAGAGACTCACAACTTTCCCACAGGAGTATGCCCCTTTAGTGGTGCAACCACTGGCAC
AGGGGGCCGGATTCGAGATGTCCAGTGCACAGGCCGCGGGGCCCACGTGGTGGCTGGCAC
TGCCGGCTATTGCTTTGGAAATCTGCATATTCCAGGTTACAATCTGCCCTGGGAGGATCT
AAGCTTCCAGTATCCTGGGAATTTTGCCCGGCCCCTGGAGGTTGCCATTGAAGCCAGTAA
TGGAGCTTCTGACTATGGCAACAAGTTTGGGGAACCAGTGCTGGCTGGCTTCGCCCGCTC
CTTGGGCCTCCAGCTCCCAGACGGCCAGCGGCGTGAGTGGATCAAGCCCATCATGTTTAG
TGGGGGCATTGGGTCCATGGAAGCTGACCACATAAGCAAGGAGGCCCCAGAGCCAGGCAT
GGAAGTTGTAAAGGTTGGAGGTCCCGTCTACAGGATTGGAGTTGGAGGTGGAGCTGCTTC
ATCTGTGCAGGTGCAGGGAGATAACACCAGTGACCTGGACTTTGGGGCTGTGCAGCGAGG
AGACCCGGAGATGGAACAGAAGATGAACCGTGTGATCAGGGCTTGTGTGGAGGCCCCCAA
GGGAAACCCCATCTGCAGCCTTCATGATCAGGGCGCTGGTGGCAATGGCAATGTCCTAAA
AGAGCTGAGTGACCCAGCTGGAGCCATCATTTACACCAGCCGCTTCCAGCTTGGGGACCC
AACCCTGAATGCCCTGGAAATCTGGGGGGCTGAGTACCAGGAATCAAATGCTCTTCTGCT
GAGGTCCCCCAACCGGGACTTCCTGACTCATGTCAGTGCCCGTGAACGTTGCCCGGCTTG
CTTCGTGGGCACCATCACTGGAGACCGGAGAATAGTGCTGGTGGACGATCGGGAGTGTCC
TGTCAGAAGAAATGGCCAGGGGGATGCCCCCCCGACACCCCCGCCAACCCCTGTGGACCT
GGAGCTCGAATGGGTGCTGGGCAAGATGCCTCGGAAGGAGTTCTTCCTGCAGAGGAAGCC
CCCCATGCTGCAGCCTCTGGCCTTGCCCCCAGGGCTGAGCGTGCACCAGGCTCTGGAGAG
GGTTCTGAGGCTGCCCGCCGTGGCCAGCAAGCGCTACCTCACCAATAAGGTGGACCGCTC
CGTGGGAGGCCTGGTGGCCCAGCAGCAGTGCGTGGGGCCCCTGCAAACTCCTCTGGCAGA
TGTAGCGGTTGTGGCACTGAGCCATGAGGAGCTCATAGGGGCTGCCACAGCCTTGGGAGA
ACAGCCAGTCAAGAGCCTGCTGGACCCAAAAGTCGCCGCCCGGCTGGCCGTGGCCGAAGC
CCTCACCAACCTGGTGTTTGCTCTGGTCACTGACCTCCGGGATGTGAAGTGTAGCGGGAA
CTGGATGTGGGCAGCCAAGCTCCCAGGGGAGGGCGCAGCTTTGGCGGATGCCTGTGAGGC
TATGGTGGCAGTGATGGCAGCCCTGGGTGTGGCAGTGGATGGTGGCAAGGACTCCCTCAG
CATGGCTGCTCGGGTTGGCACTGAGACCGTGCGGGCTCCTGGGTCACTGGTCATCTCAGC
CTATGCCGTCTGCCCAGACATCACAGCCACTGTGACCCCAGACCTCAAGCATCCTGAAGG
GAGAGGCCATCTGCTCTATGTGGCTCTGAGCCCTGGGCAGCACCGGCTCGGGGGCACAGC
TCTGGCCCAGTGCTTCTCCCAGCTTGGGGAACACCCTCCAGACCTGGACCTTCCTGAGAA
CTTGGTGCGGGCCTTCAGCATCACTCAGGGGCTGCTGAAAGACCGCCTCCTCTGCTCAGG
CCACGATGTCAGTGACGGAGGCCTCGTCACATGCCTGCTGGAGATGGCCTTTGCTGGAAA
TTGCGGGCTACAGGTGGATGTGCCTGTCCCCAGGGTTGATGTCCTGTCTGTGCTGTTCGC
TGAGGAGCCAGGCCTCGTGCTGGAGGTGCAGGAGCCAGACCTGGCCCAGGTGCTGAAGCG
TTACCGGGATGCTGGCCTCCATTGCCTGGAGCTGGGCCACACAGGCGAGGCCGGGCCCCA
CGCCATGGTCCGGGTGTCAGTGAACGGGGCTGTGGTTCTGGAGGAGCCTGTTGGGGAGCT
GCGAGCCCTCTGGGAGGAGACGAGTTTCCAGCTGGACCGGCTACAGGCAGAGCCTCGCTG
TGTGGCAGAGGAGGAACGGGGCCTGAGGGAGCGGATGGGGCCCAGCTATTGCCTGCCCCC
CACCTTTCCCAAAGCCTCCGTGCCCCGTGAGCCTGGTGGTCCCAGCCCCCGAGTCGCCAT
CTTGCGAGAGGAGGGCAGTAATGGAGACCGGGAGATGGCCGATGCCTTCCACTTAGCTGG
GTTTGAGGTATGGGACGTGACCATGCAGGACCTCTGCTCTGGGGCAATTGGGCTGGACAC
TTTCCGTGGCGTGGCCTTCGTGGGCGGCTTCAGCTATGCAGATGTCCTGGGCTCTGCCAA
AGGGTGGGCAGCTGCTGTGACCTTTCATCCCAGGGCTGGGGCTGAGCTGAGGCGCTTCCG
GAAGCGGCCAGACACCTTCAGCCTGGGCGTGTGTAATGGCTGTCAACTGCTGGCTCTGCT
CGGCTGGGTGGGAGGCGACCCCAATGAGGATGCTGCAGAGATGGGCCCTGACTCCCAGCC
AGCCCGGCCAGGCCTTCTGCTACGCCACAACCTGTCTGGGCGCTACGAGTCTCGCTGGGC
CAGCGTGCGTGTGGGGCCTGGGCCAGCCCTGATGCTGCGAGGGATGGAGGGCGCCGTGCT
GCCCGTGTGGAGTGCGCACGGGGAAGGTTACGTAGCATTTTCTTCTCCGGAACTCCAAGC
TCAGATTGAGGCCAGGGGCTTGGCTCCACTGCACTGGGCTGATGATGACGGGAACCCCAC
AGAGCAGTACCCTCTGAATCCCAATGGGTCCCCAGGGGGCGTGGCTGGCATCTGCTCCTG
TGATGGCCGCCACCTGGCTGTCATGCCTCACCCTGAGCGGGCCGTTAGGCCTTGGCAGTG
GGCATGGCGACCCCCTCCATTTGATACTCTGACCACCTCCCCCTGGCTCCAGCTCTCTAT
CAATGCCCGAAACTGGACCCTGGAAGGGAGCTGCTGA

# Metabolic_Enzyme_31_GenBank_ID_Gene:
AB002359

# Metabolic_Enzyme_31_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_31_Locus:
17p13.1

# Metabolic_Enzyme_31_SNPs:
rs11078738; rs4791641; rs35217368; rs9902252; rs34778863; rs12951103; rs1132554; rs8065961; rs7206953; rs11655563; rs7221716; rs7225220; rs11658322; rs4792691; rs9891267; rs9897627; rs12939761; rs6503094; rs4792687; rs4792701; rs9897842; rs34939404; rs35050039; rs36116498; rs34554007; rs9891699; rs35025606; rs1132556; rs28523368; rs8079155; rs8080208; rs36066344; rs11868250; rs4791636; rs28637379; rs9895234; rs9898360; rs7226094; rs7223531; rs10468482; rs11652596; rs35754346; rs11652351; rs10468467; rs4792700; rs34855598; rs36140926; rs7503264; rs34489589; rs34642794; rs35724287; rs35976967; rs1030125; rs11651199; rs12946837; rs2313286; rs35810647; rs6503096; rs7221547; rs7225429; rs888516; rs9747860

# Metabolic_Enzyme_31_General_References:
10548741; 9205841

# Metabolic_Enzyme_31_References:
Not Available

# Metabolic_Enzyme_32_ID:
5975

# Metabolic_Enzyme_32_Name:
Glutamate decarboxylase 2

# Metabolic_Enzyme_32_Synonyms:
Glutamate decarboxylase 65 kDa isoform; GAD-65; 65 kDa glutamic acid decarboxylase

# Metabolic_Enzyme_32_Gene_Name:
GAD2

# Metabolic_Enzyme_32_Protein_Sequence:
>Glutamate decarboxylase 2
MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGG
SQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQ
YVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFN
QLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFS
PGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVI
LIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIW
MHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQ
MHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEY
LYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEY
GTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL

# Metabolic_Enzyme_32_Number_of_Residues:
585

# Metabolic_Enzyme_32_Molecular_Weight:
65412

# Metabolic_Enzyme_32_Theoretical_pI:
6.89

# Metabolic_Enzyme_32_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_32_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_32_Specific_Function:
Catalyzes the production of GABA

# Metabolic_Enzyme_32_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00410  beta-Alanine metabolism;
 map00430  Taurine and hypotaurine metabolism;
 map00650  Butanoate metabolism

# Metabolic_Enzyme_32_Reaction:
L-glutamate = 4-aminobutanoate + CO2

# Metabolic_Enzyme_32_Pfam_Domain_Function:
PF00282:Pyridoxal_deC

# Metabolic_Enzyme_32_Signals:
None

# Metabolic_Enzyme_32_Transmembrane_Regions:
None

# Metabolic_Enzyme_32_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_32_EC_Link:
EC 4.1.1.15

# Metabolic_Enzyme_32_GenBank_ID_Protein:
182934

# Metabolic_Enzyme_32_SwissProt_ID:
DCE2_HUMAN (Q05329)

# Metabolic_Enzyme_32_swissprot_Name:
Not Available

# Metabolic_Enzyme_32_Genecard_id:
GAD2

# Metabolic_Enzyme_32_Geneatlas_id:
GAD2

# Metabolic_Enzyme_32_hgnc_id:
HGNC:4093

# Metabolic_Enzyme_32_PDB_ID:
Not Available

# Metabolic_Enzyme_32_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_32_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_32_Subcellular_Location:
Cytoplasm; cytosol. Cytoplasmic vesicle. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters

# Metabolic_Enzyme_32_Gene_Sequence:
>1758 bp
ATGGCATCTCCGGGCTCTGGCTTTTGGTCTTTCGGGTCGGAAGATGGCTCTGGGGATTCC
GAGAATCCCGGCACAGCGCGAGCCTGGTGCCAAGTGGCTCAGAAGTTCACGGGCGGCATC
GGAAACAAACTGTGCGCCCTGCTCTACGGAGACGCCGAGAAGCCGGCGGAGAGCGGCGGG
AGCCAACCCCCGCGGGCCGCCGCCCGGAAGGCCGCCTGCGCCTGCGACCAGAAGCCCTGC
AGCTGCTCCAAAGTGGATGTCAACTACGCGTTTCTCCATGCAACAGACCTGCTGCCGGCG
TGTGATGGAGAAAGGCCCACTTTGGCGTTTCTGCAAGATGTTATGAACATTTTACTTCAG
TATGTGGTGAAAAGTTTCGATAGATCAACCAAAGTGATTGATTTCCATTATCCTAATGAG
CTTCTCCAAGAATATAATTGGGAATTGGCAGACCAACCACAAAATTTGGAGGAAATTTTG
ATGCATTGCCAAACAACTCTAAAATATGCAATTAAAACAGGGCATCCTAGATACTTCAAT
CAACTTTCTACTGGTTTGGATATGGTTGGATTAGCAGCAGACTGGCTGACATCAACAGCA
AATACTAACATGTTCACCTATGAAATTGCTCCAGTATTTGTGCTTTTGGAATATGTCACA
CTAAAGAAAATGAGAGAAATCATTGGCTGGCCAGGGGGCTCTGGCGATGGGATATTTTCT
CCCGGTGGCGCCATATCTAACATGTATGCCATGATGATCGCACGCTTTAAGATGTTCCCA
GAAGTCAAGGAGAAAGGAATGGCTGCTCTTCCCAGGCTCATTGCCTTCACGTCTGAACAT
AGTCATTTTTCTCTCAAGAAGGGAGCTGCAGCCTTAGGGATTGGAACAGACAGCGTGATT
CTGATTAAATGTGATGAGAGAGGGAAAATGATTCCATCTGATCTTGAAAGAAGGATTCTT
GAAGCCAAACAGAAAGGGTTTGTTCCTTTCCTCGTGAGTGCCACAGCTGGAACCACCGTG
TACGGAGCATTTGACCCCCTCTTAGCTGTCGCTGACATTTGCAAAAAGTATAAGATCTGG
ATGCATGTGGATGCAGCTTGGGGTGGGGGATTACTGATGTCCCGAAAACACAAGTGGAAA
CTGAGTGGCGTGGAGAGGGCCAACTCTGTGACGTGGAATCCACACAAGATGATGGGAGTC
CCTTTGCAGTGCTCTGCTCTCCTGGTTAGAGAAGAGGGATTGATGCAGAATTGCAACCAA
ATGCATGCCTCCTACCTCTTTCAGCAAGATAAACATTATGACCTGTCCTATGACACTGGA
GACAAGGCCTTACAGTGCGGACGCCACGTTGATGTTTTTAAACTATGGCTGATGTGGAGG
GCAAAGGGGACTACCGGGTTTGAAGCGCATGTTGATAAATGTTTGGAGTTGGCAGAGTAT
TTATACAACATCATAAAAAACCGAGAAGGATATGAGATGGTGTTTGATGGGAAGCCTCAG
CACACAAATGTCTGCTTCTGGTACATTCCTCCAAGCTTGCGTACTCTGGAAGACAATGAA
GAGAGAATGAGTCGCCTCTCGAAGGTGGCTCCAGTGATTAAAGCCAGAATGATGGAGTAT
GGAACCACAATGGTCAGCTACCAACCCTTGGGAGACAAGGTCAATTTCTTCCGCATGGTC
ATCTCAAACCCAGCGGCAACTCACCAAGACATTGACTTCCTGATTGAAGAAATAGAACGC
CTTGGACAAGATTTATAA

# Metabolic_Enzyme_32_GenBank_ID_Gene:
M81882

# Metabolic_Enzyme_32_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_32_Locus:
10p11.23

# Metabolic_Enzyme_32_SNPs:
rs2839672; rs2839678; rs1805397; rs2229845; rs7919405; rs1556234; rs3781106; rs8190809; rs1335547; rs3781105; rs3781107; rs8190811; rs8190812; rs8190817; rs8190816; rs8190800; rs8190590; rs8190813; rs8190805; rs8190801; rs7073217; rs8190802; rs8190814; rs8190807; rs8190815; rs8190803; rs992990; rs2368160; rs2368159; rs913963; rs913964; rs1999241; rs870341; rs928197; rs8190604; rs7906725; rs3781109; rs6482551; rs1330581; rs8190764; rs4749108; rs6482541; rs7897510; rs8190780; rs7071922; rs3893052; rs6482537; rs7073119; rs7900739; rs2839671; rs3781108; rs11015008; rs12267286; rs4994426; rs7893400; rs1330582; rs8190754; rs7087663; rs7900976; rs12414701; rs7074534; rs4144102; rs7074235; rs7068224; rs3847380; rs3781113; rs7902107; rs7076544; rs6482540; rs7913676; rs7908975; rs6482550; rs3781117; rs4747548; rs8190748; rs4749105; rs8190706; rs8190704; rs7087011; rs3781114; rs4749101; rs3847378; rs7893194; rs4747550; rs7913524; rs4749102; rs8190798; rs4749107; rs7095327; rs4747547; rs4747549; rs3847379; rs6482538; rs8190598; rs3824694; rs17667367; rs8190658; rs3781111; rs7081084; rs11015015; rs8190694; rs7897355; rs8190734; rs3904297; rs10828963; rs928198; rs913962; rs11015025; rs8190624; rs7099569; rs7918935; rs7072964; rs8190628; rs11015024; rs8190714; rs4749103; rs8190690; rs8190635; rs3781112; rs2839676; rs7909909; rs8190720; rs8190645; rs16926761; rs8190770; rs11594057; rs870342; rs6482544; rs7898281; rs1935996; rs8190708; rs8190716; rs3904298; rs8190597; rs8190779; rs3781116; rs12253114; rs8190660; rs7089304; rs3893253; rs7074934; rs2839675; rs8190796; rs4749104; rs12098763; rs7080514; rs8190685; rs7067571; rs6482543; rs7068510; rs8190611; rs12242971; rs1805398; rs7072137; rs8190689; rs8190646; rs11015010; rs11015028; rs8190718; rs2298124; rs2839674; rs8190713; rs7100268; rs6482548; rs7903208; rs7078680; rs1805399; rs8190678; rs8190701; rs8190612; rs3781118; rs3904296; rs8190637; rs8190683; rs8190673; rs8190782; rs7079102; rs6482542; rs11015004; rs12258601; rs12263667; rs7909902; rs8190620; rs8190650; rs7911425; rs6482547; rs913965; rs8190794; rs8190741; rs8190621; rs7895479; rs1330579; rs8190786; rs8190665; rs8190594; rs8190778; rs8190656; rs16926784; rs8190618; rs8190675; rs8190711; rs8190739; rs7091779; rs8190616; rs8190648; rs8190763; rs8190661; rs11015012; rs8190773; rs12248404; rs8190641; rs8190746; rs8190757; rs8190668; rs12358823; rs8190776; rs8190750; rs8190697; rs11015016; rs7067786; rs8190695; rs8190623; rs12258107; rs6482539; rs8190723; rs8190797; rs8190738; rs8190765; rs8190787; rs7915657; rs7912687; rs12251044; rs10828964; rs8190608; rs8190667; rs8190596; rs16926747; rs8190781; rs8190642; rs8190639; rs8190751; rs8190784; rs8190627; rs3781110; rs8190696; rs8190703; rs12254792; rs8190593; rs8190715; rs8190737; rs8190634; rs8190727; rs10160178; rs12098764; rs8190771; rs8190736; rs8190682; rs2839677; rs8190651; rs8190785; rs11015018; rs4111544; rs7911393; rs10466096; rs7080693; rs11015003; rs8190709; rs7909127; rs7922748; rs8190733; rs11015017; rs8190602; rs8190672; rs8190789; rs3904299; rs8190692; rs8190626; rs8190632; rs8190774; rs11015002; rs12243085; rs8190768; rs8190722; rs8190617; rs7905275; rs8190752; rs8190595; rs8190728; rs1330580; rs7893528; rs11015011; rs12360108; rs8190607; rs8190772; rs8190766; rs8190693; rs8190647; rs7089218; rs6482549; rs10466098; rs8190756; rs8190775; rs8190744; rs7914135; rs12243037; rs12240863; rs8190758; rs8190670; rs7076905; rs12269473; rs8190721; rs8190606; rs8190615; rs8190649; rs2236418; rs3758446; rs4749111; rs8190582; rs2839669; rs2839670; rs4747553; rs4749110; rs7090727; rs4747551; rs7090581; rs4747552; rs2236417; rs8190586; rs1065239; rs8190588; rs8190825; rs8190585; rs8190587; rs8190584; rs8190823; rs2839673; rs8190730; rs8190671; rs8190600; rs8190591; rs8190729; rs8190799; rs8190804; rs34587935; rs41279918; rs8190818; rs1360845; rs8190821; rs17847106; rs8190806; rs8190819; rs8190820; rs8190810; rs8190808; rs2210118; rs35598312; rs35399576; rs8190609; rs8190724; rs11015005; rs11015026; rs8190753; rs8190747; rs11812646; rs11015007; rs8190731; rs16926771; rs34544929; rs8190783; rs8190680; rs8190742; rs7914958; rs11424034; rs34446027; rs10706901; rs8190687; rs8190795; rs8190792; rs12242900; rs7912720; rs12765251; rs8190638; rs17847108; rs35729928; rs35302027; rs8190674; rs28411087; rs36068216; rs11015021; rs12413327; rs41279916; rs8190760; rs3831349; rs35525470; rs8190702; rs12240533; rs8190759; rs7077030; rs35027140; rs8190657; rs8190743; rs35001308; rs35095406; rs8190664; rs35193512; rs8190676; rs7898671; rs34460749; rs7910714; rs8190610; rs8190601; rs11015029; rs34165540; rs10571094; rs34714031; rs17847113; rs8190655; rs10466097; rs8190691; rs34544347; rs8190788; rs34492981; rs11397236; rs8190640; rs8190767; rs34551923; rs11015013; rs12240390; rs17847119; rs958295; rs7896603; rs8190613; rs11351928; rs8190793; rs35560251; rs8190777; rs12258225; rs4749109; rs35466733; rs8190619; rs12764007; rs8190677; rs8190712; rs8190684; rs8190652; rs8190761; rs11015023; rs8190717; rs3925895; rs12780466; rs35967087; rs10691988; rs41279914; rs8190654; rs35473617; rs7906622; rs8190622; rs8190699; rs8190700; rs35554915; rs8190790; rs8190614; rs34282513; rs7904959; rs35460917; rs35692804; rs35701656; rs5783968; rs41304597; rs8190740; rs11015030; rs7910604; rs12258527; rs4749100; rs8190755; rs12265834; rs7906659; rs7911822; rs8190681; rs11382565; rs10550716; rs8190726; rs41304609; rs7900313; rs12258214; rs8190599; rs11015014; rs8190633; rs8190605; rs11594128; rs7084058; rs8190643; rs35046451; rs7897227; rs35449881; rs11015009; rs35322930; rs35856372; rs35871778; rs11389512; rs8190636; rs11437464; rs8190653; rs35327186; rs35218393; rs8190745; rs34436183; rs11015006; rs35900771; rs8190732; rs8190735; rs12252062; rs7074897; rs8190791; rs8190725; rs8190666; rs8190669; rs8190631; rs8190707; rs8190679; rs8190749; rs34964656; rs34166651; rs35778757; rs8190719; rs8190710; rs8190686; rs35829665; rs11407523; rs8190625; rs11417128; rs8190659; rs36008357; rs16926745; rs8190698; rs8190769; rs11014999; rs8190603; rs8190705; rs7078821; rs11015027; rs8190762; rs8190644; rs4589175; rs8190589; rs8190822; rs8190583; rs34861013; rs10508715; rs11014998; rs11015031; rs11015032; rs11591556; rs12248143; rs12256696; rs12264198; rs12265385; rs1330574; rs16926835; rs16926836; rs1888251; rs2150157; rs2150158; rs2150159; rs2150160; rs2839668; rs7899642; rs7915415; rs7922791; rs8190828; rs8190830; rs876845; rs876846; rs876847; rs876848; rs882138; rs994502

# Metabolic_Enzyme_32_General_References:
1924293; 1549570; 8088791; 7680313; 8243826; 8999827; 12356867

# Metabolic_Enzyme_32_References:
Not Available

# Metabolic_Enzyme_33_ID:
6135

# Metabolic_Enzyme_33_Name:
Delta 1-pyrroline-5-carboxylate synthetase

# Metabolic_Enzyme_33_Synonyms:
P5CS; Aldehyde dehydrogenase 18 family member A1[Includes: Glutamate 5-kinase; Gamma-glutamyl kinase; GK; Gamma-glutamyl phosphate reductase; GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase]

# Metabolic_Enzyme_33_Gene_Name:
ALDH18A1

# Metabolic_Enzyme_33_Protein_Sequence:
>Delta 1pyrroline5carboxylate synthetase
MLSQVYRCGFQPFNQHLLPWVKCTTVFRSHCIQPSVIRHVRSWSNIPFITVPLSRTHGKS
FAHRSELKHAKRIVVKLGSAVVTRGDECGLALGRLASIVEQVSVLQNQGREMMLVTSGAV
AFGKQRLRHEILLSQSVRQALHSGQNQLKEMAIPVLEARACAAAGQSGLMALYEAMFTQY
SICAAQILVTNLDFHDEQKRRNLNGTLHELLRMNIVPIVNTNDAVVPPAEPNSDLQGVNV
ISVKDNDSLAARLAVEMKTDLLIVLSDVEGLFDSPPGSDDAKLIDIFYPGDQQSVTFGTK
SRVGMGGMEAKVKAALWALQGGTSVVIANGTHPKVSGHVITDIVEGKKVGTFFSEVKPAG
PTVEQQGEMARSGGRMLATLEPEQRAEIIHHLADLLTDQRDEILLANKKDLEEAEGRLAA
PLLKRLSLSTSKLNSLAIGLRQIAASSQDSVGRVLRRTRIAKNLELEQVTVPIGVLLVIF
ESRPDCLPQVAALAIASGNGLLLKGGKEAAHSNRILHLLTQEALSIHGVKEAVQLVNTRE
EVEDLCRLDKMIDLIIPRGSSQLVRDIQKAAKGIPVMGHSEGICHMYVDSEASVDKVTRL
VRDSKCEYPAACNALETLLIHRDLLRTPLFDQIIDMLRVEQVKIHAGPKFASYLTFSPSE
VKSLRTEYGDLELCIEVVDNVQDAIDHIHKYGSSHTDVIVTEDENTAEFFLQHVDSACVF
WNASTRFSDGYRFGLGAEVGISTSRIHARGPVGLEGLLTTKWLLRGKDHVVSDFSEHGSL
KYLHENLPIPQRNTN

# Metabolic_Enzyme_33_Number_of_Residues:
795

# Metabolic_Enzyme_33_Molecular_Weight:
87304

# Metabolic_Enzyme_33_Theoretical_pI:
7.13

# Metabolic_Enzyme_33_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, carboxyl group as acceptor
Function:  glutamate 5-kinase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Function:  glutamate-5-semialdehyde dehydrogenase activity
 ||
>>>
Process:  glutamine family amino acid metabolism
Process:  proline metabolism
Process:  proline biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  amino acid biosynthesis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_33_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_33_Specific_Function:
ATP + L-glutamate = ADP + L-glutamate 5- phosphate

# Metabolic_Enzyme_33_Pathway:
map00220  Urea cycle and metabolism of amino groups

# Metabolic_Enzyme_33_Reaction:
ATP + L-glutamate = ADP + L-glutamate 5-phosphate

# Metabolic_Enzyme_33_Pfam_Domain_Function:
PF00696:AA_kinase

# Metabolic_Enzyme_33_Signals:
None

# Metabolic_Enzyme_33_Transmembrane_Regions:
None

# Metabolic_Enzyme_33_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_33_EC_Link:
EC 2.7.2.11;EC 1.2.1.41

# Metabolic_Enzyme_33_GenBank_ID_Protein:
1304314

# Metabolic_Enzyme_33_SwissProt_ID:
P5CS_HUMAN (P54886)

# Metabolic_Enzyme_33_swissprot_Name:
Not Available

# Metabolic_Enzyme_33_Genecard_id:
ALDH18A1

# Metabolic_Enzyme_33_Geneatlas_id:
ALDH18A1

# Metabolic_Enzyme_33_hgnc_id:
HGNC:9722

# Metabolic_Enzyme_33_PDB_ID:
Not Available

# Metabolic_Enzyme_33_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_33_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_33_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane

# Metabolic_Enzyme_33_Gene_Sequence:
>2388 bp
ATGTTGAGTCAAGTTTACCGCTGTGGGTTCCAGCCCTTCAACCAACATCTTCTGCCCTGG
GTCAAGTGTACAACCGTCTTCAGATCTCATTGTATCCAGCCTTCAGTCATCAGACATGTT
CGTTCTTGGAGCAACATCCCGTTTATCACTGTACCCCTCAGTCGTACACATGGCAAGTCC
TTCGCCCACCGCAGTGAGCTGAAGCATGCCAAGAGAATCGTGGTGAAGCTCGGCAGTGCC
GTGGTGACCCGAGGGGATGAATGTGGCCTGGCCCTGGGGCGCTTGGCATCTATTGTTGAG
CAGGTATCAGTGCTGCAGAATCAGGGCAGAGAGATGATGCTGGTGACCAGTGGAGCCGTA
GCCTTTGGCAAACAAACGTTGCGCCATGAGATCCTTCTGTCTCAGAGCGTGCGGCAGGCC
CTCCACTCGGGGCAGAACCAGCTGAAAGAAATGGCAATTCCAGTCTTAGAGGCACGAGCC
TGTGCAGCTGCCGGACAGAGTGGGCTGATGGCCTTGTATGAGGCTATGTTTACCCAGTAC
AGCATCTGTGCTGCCCAGATTTTGGTGACCAATTTGGATTTCCATGATGAGCAGAAGCGC
CGGAACCTCAATGGAACACTTCATGAACTCCTTAGAATGAACATTGTCCCCATTGTCAAC
ACAAATGATGCTGTTGTCCCCCCAGCTGAGCCCAACAGTGACCTGCAGGGGGTAAATGTT
ATTAGTGTTAAAGATAATGATAGCCTGGCTGCCCGACTGGCTGTGGAAATGAAAACTGAT
CTCTTGATTGTCCTTCCAGATGTAGAAGGCCTTTTTGACAGCCCCCCAGGTTCAGATGAT
GCAAAGCTTATTGATATATTTTATCCCGGAGATCAGCAGTCTGTGACATTTGGACCCAAG
TCTAGAGTGGGAAATGGGTGCATGGAAGCCAAGGTGAAAAGCACCCTCTGGGCTTTGCAA
GGTGGCACTTCTGTTGTTATTGCCAATGGAACCCACCCAAAGGTGTCTGGGCACGTCATC
ACAGACATTGTGGAGGGGAAGAAAGTTGGTACCTTCTTTTCAGAAGTAAAGCCTGCAGGC
CCTACTGTTGAGCAGCAGGGAGAAATGGCGCGATCTGGAGGAAGGATGTTGGCCACCTTG
GAACCTGAGCAGAGAGCAGAAATTATCCATCATCTGGCTGATCTGTTGACGGACCAGCGT
GATGAGATCCTGTTAGCCAACAAAAAAGACTTGGAGGAGGCAGAGGGGAGACTTGCAGCT
CCTCTGCTGAAACGTTTAAGCCTCTCCACATCCAAATTGAACAGCCTGGCCATCGGTCTG
CGACAGATCGCAGCCTCCTCCCAGGACAGCGTGGGACGTGTTTTGCGCCGCACCCGAATC
GCCAAAAACTTGGAACTGGAACAAGTGACTGTCCCAATTGGAGTTCTGCTGGTGATCTTT
GAATCTCGTCCTGACTGTCCTACCCCAGGTGGCAGCTTTGCTATCGCAAGTGGCAATGGC
TTGTTACTCAAAGGAGGGAAGGAGGCTGCACACAGCAACCGGATTCTCCACCTCCTGACC
CAGGAGGCTCTCTCAATCCATGGAGTCAAGGAGGCCGTGCAACTGGTGAATACCAGAGAA
GAAGTTGAAGATCTTTGCCGCCTAGACAAAATGATAGATCTGATCATTCCACGTGGCTCT
TCCCAGCTGGTCAGAGACATCCAGAAAGCTGCTAAGGGGATTCCAGTGATGGGGCACAGC
GAAGGGATCTGTCACATGTATGTGGATTCCGAGGCCAGTGTTGATAAGGTCACCAGGCTA
GTCAGAGACTCTAAATGTGAATATCCAGCTGCCTGTAATGCTTTGGAGACTTTGTTAATC
CACCGGGATCTGCTCAGGACACCATTATTTGACCAGATCATTGATATGCTGAGAGTGGAA
CAGGTAAAAATTCATGCAGGCCCCAAATTTGCCTCCTATCTGACCTTCAGCCCCTCCGAA
GTGAAGTCACTCCGAACTGAGTATGGGGACCTGGAATTATGCATTGAAGTAGTGGACAAC
GTTCAGGATGCCATTGACCACATCCACAAGTATGGCAGCTCCCACACGGATGTCATCGTC
ACAGAGGACGAAAACACAGCGGAGTTCTTCCTGCAGCACGTAGACAGTGCCTGTGTGTTC
TGGAATGCCAGCACTCGCTTTTCTGATGGTTACCGCTTTGGACTGGGAGCTGAAGTGGGA
ATCAGTACATCGAGAATCCACGCCCGGGGACCAGTAGGACTTGAGGGACTGCTTACTACT
AAGTGGCTGCTGCGAGGGAAGGACCACGTGGTCTCAGATTTCTCAGAGCATGGAAGTTTA
AAATATCTTCATGAGAACCTCCCTATTCCTCAGAGAAACACCAACTGA

# Metabolic_Enzyme_33_GenBank_ID_Gene:
X94453

# Metabolic_Enzyme_33_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_33_Locus:
10q24.3

# Metabolic_Enzyme_33_SNPs:
rs3765571; rs2275272; rs1804934; rs4037; rs8758; rs1053905; rs2225893; rs943341; rs12267876; rs2211002; rs3793746; rs2225892; rs34297443; rs749049; rs1409709; rs943343; rs483920; rs2296689; rs943342; rs7895976; rs10882642; rs12778814; rs2986401; rs3750700; rs945958; rs12780161; rs10786227; rs10509687; rs749050; rs10882644; rs2296691; rs9663413; rs10882641; rs3829157; rs7909569; rs496426; rs10882643; rs10748634; rs11188398; rs10882640; rs12414904; rs3793749; rs4258314; rs2296692; rs1933164; rs4918950; rs11592789; rs2275273; rs535449; rs4417206; rs10882639; rs3793748; rs4290159; rs11596004; rs3793751; rs7099284; rs11188399; rs10882646; rs497331; rs10882647; rs11188414; rs7100377; rs10786228; rs3750701; rs11188411; rs11188403; rs2296690; rs10786226; rs11592809; rs7897091; rs10882638; rs501819; rs17111068; rs10509688; rs10882645; rs12414244; rs7092594; rs1890186; rs11188410; rs12244124; rs11188396; rs2485642; rs11188412; rs2004611; rs7069943; rs11188417; rs9787589; rs34832675; rs507017; rs11188397; rs2017218; rs11188416; rs17111041; rs556869; rs12357333; rs12768006; rs1409710; rs12267327; rs1268608; rs2485643; rs546265; rs1890187; rs7893577; rs11592213; rs11188409; rs7915622; rs12773566; rs11188407; rs11591779; rs9664039; rs11188415; rs11188402; rs536893; rs3763707; rs11188394; rs524084; rs12359272; rs11188393; rs11188395; rs7913204; rs3763706; rs7917792; rs1063928; rs41291564; rs11541778; rs11541780; rs41291566; rs12358342; rs11364932; rs5787151; rs7100702; rs35053689; rs11364931; rs12251664; rs34421345; rs11541781; rs10610864; rs41291562; rs11287393; rs5787152; rs34306795; rs10617093; rs3793747; rs12249571; rs11287394; rs7919622; rs4918949; rs11188413; rs3763708; rs35183969; rs35973522; rs34302520; rs9419807; rs11188406; rs36117450; rs34085557; rs4918951; rs34340277; rs35895748; rs35712039; rs7076303; rs35975690; rs34288576; rs11188404; rs34067439; rs34011550; rs11816440; rs10625012; rs11188408; rs12769303; rs12358350; rs35613419; rs10637751; rs35157765; rs35364896; rs34586419; rs499714; rs9420675; rs33925147; rs11188401; rs11188405; rs34630368; rs9419808; rs34060579; rs34704889; rs34287704; rs11596976; rs35082362; rs34993856; rs34800190; rs35411388; rs35983060; rs35138893; rs2152916; rs34332904; rs11188400; rs10047275; rs17111056; rs35009553; rs1933163; rs4581373; rs28549756; rs34460315; rs36116345; rs4918952; rs4460748; rs34426141; rs12412369; rs11396427; rs34752566; rs34069713; rs35192635; rs12765494; rs35822210; rs36101521; rs35283994; rs34323616; rs1064654; rs10882636; rs10882637; rs10882649; rs11188385; rs11188388; rs11188389; rs11188390; rs11188392; rs11188418; rs11188421; rs14997; rs2282305; rs35722210; rs476373; rs476392; rs479505; rs4917698; rs4918954; rs4918955; rs4918956; rs496641; rs540963; rs543672; rs561156; rs568401; rs6946; rs701891; rs7905711

# Metabolic_Enzyme_33_General_References:
8761662; 10037775

# Metabolic_Enzyme_33_References:
Not Available

# Metabolic_Enzyme_34_ID:
6136

# Metabolic_Enzyme_34_Name:
5-oxoprolinase

# Metabolic_Enzyme_34_Synonyms:
5-oxo-L-prolinase; Pyroglutamase; 5- OPase

# Metabolic_Enzyme_34_Gene_Name:
OPLAH

# Metabolic_Enzyme_34_Protein_Sequence:
>5oxoprolinase
MGSPEGRFHFAIDRGGTFTDVFAQCPGGHVRVLKLLSEDPANYADAPTEGIRRILEQEAG
MLLPRDQPLDSSHIASIRMGTTVATNALLERKGERVALLVTRGFRDLLHIGTQARGDLFD
LAVPMPEVLYEEVLEVDERVVLHRGEAGTGTPVKGRTGDLLEVQQPVDLGALRGKLEGLL
SRGIRSLAVVLMHSYTWAQHEQQVGVLARELGFTHVSLSSEAMPMVRIVPRGHTACADAY
LTPAIQRYVQGFCRGFQGQLKDVQVLFMRSDGGLAPMDTFSGSSAVLSGPAGGVVGYSAT
TYQQEGGQPVIGFDMGGTSTDVSRYAGEFEHVFEASTAGVTLQAPQLDINTVAAGGGSRL
FFRSGLFVVGPESAGAHPGPACYRKGGPVTVTDANLVLGRLLPASFPCIFGPGENQPLSP
EASRKALEAVATEVNSFLTNGPCPASPLSLEEVAMGFVRVANEAMCRPIRALTQARGHDP
SAHVLACFGGAGGQHACAIARALGMDTVHIHRHSGLLSALGLALADVVHEAQEPCSLLYA
PETFVQLDQRLSRLEEQCVDALQAQGFPRSQISTESFLHLRYQGTDCALMVSAHQHPATA
RSPRAGDFGAAFVERYMREFGFVIPERPVVVDDVRVRGTGRSGLRLEDAPKAQTGPPRVD
KMTQCYFEGGYQETPVYLLAELGYGHKLHGPCLIIDSNSTILVEPGCQAEVTKTGDICIS
VGAEVPGTVGPQLDPIQLSIFSHRFMSIAEQMGRILQRTAISTNIKERLDFSCALFGPDG
GLVSNAPHIPVHLGAMQETVQFQIQHLGADLHPGDVLLSNHPSAGGSHLPDLTVITPVFW
PGQTRPVFYVASRGHHADIGGITPGSMPPHSTMLQQEGAVFLSFKLVQGGVFQEEAVTEA
LRAPGKVPNCSGTRNLHDNLSDLRAQVAANQKGIQLVGELIGQYGLDVVQAYMGHIQANA
ELAVRDMLRAFGTSRQARGLPLEVSSEDHMDDGSPIRLRVQISLSQGSAVFDFSGTGPEV
FGNLNAPRAVTLSALIYCLRCLVGRDIPLNQGCLAPVRVVIPRGSILDPSPEAAVVGGNV
LTSQRVVDVILGAFGACAASQGCMNNVTLGNAHMGYYETVAGGAGAGPSWHGRSGVHSHM
TNTRITDPEILESRYPVILRRFELRRGSGGRGRFRGGDGVTRELLFREEALLSVLTERRA
FRPYGLHGGEPGARGLNLLIRKNGRTVNLGGKTSVTVYPGDVFCLHTPGGGGYGDPEDPA
PPPGSPPQALAFPEHGSVYEYRRAQEAV

# Metabolic_Enzyme_34_Number_of_Residues:
1288

# Metabolic_Enzyme_34_Molecular_Weight:
137459

# Metabolic_Enzyme_34_Theoretical_pI:
6.56

# Metabolic_Enzyme_34_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_34_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_34_Specific_Function:
Catalyzes the cleavage of 5-oxo-L-proline to form L- glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate

# Metabolic_Enzyme_34_Pathway:
map00480  Glutathione metabolism

# Metabolic_Enzyme_34_Reaction:
ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate

# Metabolic_Enzyme_34_Pfam_Domain_Function:
PF05378:Hydant_A_N;
PF01968:Hydantoinase_A;
PF02538:Hydantoinase_B

# Metabolic_Enzyme_34_Signals:
None

# Metabolic_Enzyme_34_Transmembrane_Regions:
None

# Metabolic_Enzyme_34_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_34_EC_Link:
EC 3.5.2.9

# Metabolic_Enzyme_34_GenBank_ID_Protein:
46020040

# Metabolic_Enzyme_34_SwissProt_ID:
OPLA_HUMAN (O14841)

# Metabolic_Enzyme_34_swissprot_Name:
Not Available

# Metabolic_Enzyme_34_Genecard_id:
OPLAH

# Metabolic_Enzyme_34_Geneatlas_id:
OPLAH

# Metabolic_Enzyme_34_hgnc_id:
HGNC:8149

# Metabolic_Enzyme_34_PDB_ID:
Not Available

# Metabolic_Enzyme_34_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_34_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_34_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_34_Gene_Sequence:
>3867 bp
ATGGGCAGCCCCGAGGGCCGCTTCCACTTTGCCATCGACCGTGGGGGTACCTTCACAGAC
GTCTTTGCCCAGTGCCCAGGGGGGCACGTGCGGGTCTTAAAACTGCTCTCAGAGGACCCT
GCCAACTATGCGGACGCGCCAACCGAAGGCATCCGCCGCATCCTGGAGCAGGAGGCCGGC
ATGCTCCTGCCCCGGGACCAGCCGCTGGACTCCAGTCATATCGCCAGCATCCGCATGGGC
ACCACAGTGGCCACCAACGCACTGCTGGAGCGGAAGGGGGAGCGGGTGGCGCTGCTGGTG
ACACGTGGCTTCCGAGACCTGCTGCACATTGGCACCCAAGCCCGTGGGGACCTCTTTGAC
CTGGCCGTGCCCATGCCTGAGGTGCTGTATGAAGAGGTGCTGGAGGTGGACGAACGCGTG
GTGCTGCACCGTGGAGAGGCGGGCACCGGGACGCCTGTGAAAGGCCGCACGGGGGACCTG
CTGGAAGTGCAGCAGCCTGTGGACCTGGGGGCCCTGCGTGGGAAGCTGGAGGGGCTGCTA
TCTCGAGGCATCCGCAGCCTGGCTGTGGTGCTCATGCACTCGTACACGTGGGCCCAGCAT
GAGCAGCAGGTGGGTGTGCTGGCCCGGGAGCTGGGCTTCACGCACGTGTCACTGTCCTCG
GAGGCCATGCCCATGGTGCGCATCGTCCCTCGGGGGCACACGGCCTGTGCCGACGCCTAC
CTCACGCCCGCCATCCAGCGCTACGTGCAGGGCTTCTGCCGTGGCTTCCAGGGCCAACTC
AAGGATGTGCAGGTGTTGTTCATGCGCTCCGATGGCGGCCTGGCGCCCATGGACACCTTC
AGCGGCTCCAGTGCTGTGCTCTCGGGCCCGGCCGGCGGCGTGGTGGGCTACTCAGCCACC
ACCTACCAGCAGGAGGGTGGCCAGCCTGTCATCGGCTTTGACATGGGAGGCACGTCCACG
GATGTGAGCCGCTATGCTGGGGAATTCGAGCACGTCTTCGAGGCCAGCACAGCTGGCGTC
ACCCTCCAGGCCCCGCAGCTGGACATCAACACCGTGGCAGCGGGAGGGGGTTCCCGCCTC
TTCTTCAGGTCTGGCCTCTTTGTGGTTGGGCCCGAGTCAGCAGGAGCCCACCCAGGACCC
GCCTGCTACCGCAAAGGGGGCCCTGTGACAGTGACGGATGCTAATCTGGTCCTGGGTCGC
CTGCTGCCTGCCTCCTTCCCCTGCATTTTTGGGCCGGGAGAGAACCAACCACTTTCCCCT
GAGGCCTCCCGCAAAGCCCTGGAGGCTGTGGCCACTGAGGTCAACAGCTTCCTGACCAAC
GGGCCCTGCCCGGCCTCCCCGCTGAGCCTGGAGGAGGTGGCCATGGGGTTCGTGCGCGTG
GCCAACGAGGCCATGTGCCGGCCCATCCGTGCACTCACGCAGGCAAGAGGCCATGACCCC
TCAGCCCATGTGCTGGCCTGCTTTGGGGGAGCTGGTGGGCAGCATGCATGTGCCATCGCC
CGGGCCCTGGGCATGGACACGGTGCACATCCACAGGCACAGTGGGCTGCTGTCGGCCCTG
GGGCTGGCCCTGGCTGACGTGGTGCATGAGGCACAGGAACCCTGCTCCCTGCTCTACGCG
CCTGAGACCTTCGTGCAGCTGGACCAGAGGCTGAGCCGCCTGGAGGAGCAGTGTGTGGAT
GCTCTGCAGGCCCAGGGCTTCCCCAGGTCCCAGATCAGCACTGAGAGCTTCCTGCACCTG
CGCTACCAGGGCACGGACTGTGCTCTGATGGTGTCTGCCCACCAGCACCCAGCCACAGCC
CGCTCGCCCCGTGCGGGGGACTTCGGGGCAGCCTTTGTGGAGCGGTACATGAGGGAGTTT
GGCTTTGTCATACCTGAGCGGCCGGTGGTCGTGGACGATGTGCGAGTGCGGGGCACCGGC
CGCAGTGGTCTTCGCCTCGAGGATGCCCCCAAAGCCCAGACCGGGCCTCCCCGGGTGGAC
AAGATGACCCAGTGCTACTTTGAGGGGGGCTACCAGGAGACCCCTGTGTACCTGCTGGCA
GAGCTGGGCTATGGGCACAAGCTCCATGGGCCCTGCCTCATCATCGACAGTAACAGCACC
ATCCTGGTGGAGCCAGGTTGCCAGGCAGAGGTGACCAAGACAGGGGACATCTGCATCTCC
GTGGGGGCCGAAGTCCCCGGCACAGTGGGCCCCCAGCTGGACCCTATCCAGCTGTCCATC
TTCTCACACCGCTTCATGAGCATTGCTGAGCAGATGGGCCGCATCCTGCAGCGCACAGCC
ATCTCCACCAACATCAAGGAGCGTCTGGACTTCTCCTGTGCCCTCTTTGGGCCCGATGGG
GGGCTGGTGTCCAATGCCCCCCACATCCCTGTGCACCTGGGTGCCATGCAGGAGACGGTG
CAGTTCCAGATTCAGCACCTGGGGGCCGATCTCCACCCTGGCGACGTGCTACTGAGCAAC
CATCCCAGTGCCGGGGGCAGCCACCTGCCAGACCTGACTGTTATCACACCGGTGTTTTGG
CCGGGTCAGACGCGGCCTGTGTTCTATGTGGCCAGCCGAGGGCACCACGCAGACATCGGG
GGCATCACACCAGGCTCCATGCCCCCCCACTCCACCATGCTGCAACAGGAGGGTGCCGTC
TTTCTGTCCTTCAAACTTGTCCAGGGGGGCGTCTTCCAGGAGGAGGCGGTGACGGAGGCC
CTGCGGGCGCCAGGCAAGGTCCCCAACTGCAGCGGAACCAGAAACCTGCACGACAACCTG
TCGGACCTCCGTGCCCAGGTGGCAGCCAACCAGAAGGGCATCCAGCTGGTGGGGGAGCTC
ATTGGGCAGTACGGCCTGGACGTGGTGCAGGCCTACATGGGCCATATTCAGGCAAACGCT
GAGCTGGCCGTGCGAGACATGTTGCGTGCCTTTGGAACCTCCCGGCAGGCCCGGGGCCTG
CCCCTGGAGGTGTCCTCGGAAGACCACATGGACGACGGTTCCCCCATCCGCCTCCGTGTG
CAGATCAGCCTGAGTCAGGGCAGCGCTGTGTTTGACTTCAGCGGCACTGGGCCGGAGGTG
TTTGGTAATCTCAACGCACCGCGGGCCGTAACCCTGTCCGCCCTCATCTACTGCCTGCGC
TGTCTGGTGGGCCGCGACATCCCACTCAACCAGGGCTGCCTGGCGCCAGTGCGCGTGGTC
ATTCCCCGAGGCTCCATCCTGGACCCGTCGCCCGAGGCGGCGGTGGTGGGCGGCAACGTG
CTCACGTCGCAGCGCGTGGTGGATGTCATCCTGGGGGCCTTTGGGGCCTGCGCCGCCTCC
CAGGGCTGCATGAACAACGTGACCCTGGGCAACGCCCACATGGGCTACTACGAGACGGTG
GCGGGCGGCGCGGGCGCGGGTCCCAGCTGGCACGGGCGCAGCGGTGTGCACAGCCACATG
ACCAACACACGCATCACCGACCCTGAGATCCTGGAGAGCCGGTACCCGGTCATCCTGCGC
CGCTTCGAGCTGCGGCGGGGCTCGGGGGGCAGAGGCCGCTTCCGAGGCGGCGACGGCGTC
ACCCGCGAGCTGCTCTTTCGTGAGGAGGCGCTGCTGTCAGTGCTGACCGAGCGCCGCGCC
TTCCGGCCATACGGGCTCCACGGGGGCGAGCCTGGCGCCCGCGGCCTAAACCTGCTGATC
CGCAAAAACGGCCGGACGGTGAATCTGGGCGGCAAGACGTCGGTGACCGTGTACCCCGGG
GATGTGTTCTGTCTCCACACGCCCGGCGGCGGTGGCTATGGGGACCCGGAGGACCCCGCC
CCACCGCCGGGGTCGCCCCCGCAAGCACTGGCCTTTCCCGAGCACGGCAGCGTCTATGAG
TATCGCCGGGCCCAGGAGGCCGTGTGA

# Metabolic_Enzyme_34_GenBank_ID_Gene:
AB122018

# Metabolic_Enzyme_34_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_34_Locus:
8q24.3

# Metabolic_Enzyme_34_SNPs:
rs3935209; rs11993268; rs6558292; rs11996522; rs11986647; rs28475718; rs11993554; rs11136253; rs11777194; rs7459752; rs7003860; rs28549706; rs7833558; rs7004867; rs11985564; rs28428956; rs10107332; rs28433482; rs11994129; rs28715287; rs28699594; rs11989295; rs13268150; rs11986960; rs35893868; rs4077485; rs4977177; rs6991344; rs7005971; rs7017102; rs7465260; rs7838609

# Metabolic_Enzyme_34_General_References:
Not Available

# Metabolic_Enzyme_34_References:
Not Available

# Metabolic_Enzyme_35_ID:
5567

# Metabolic_Enzyme_35_Name:
Amidophosphoribosyltransferase precursor

# Metabolic_Enzyme_35_Synonyms:
Glutamine phosphoribosylpyrophosphate amidotransferase; ATASE; GPAT

# Metabolic_Enzyme_35_Gene_Name:
PPAT

# Metabolic_Enzyme_35_Protein_Sequence:
>Amidophosphoribosyltransferase precursor
MELEELGIREECGVFGCIASGEWPTQLDVPHVITLGLVGLQHRGQESAGIVTSDGSSVPT
FKSHKGMGLVNHVFTEDNLKKLYVSNLGIGHTRYATTGKCELENCQPFVVETLHGKIAVA
HNGELVNAARLRKKLLRHGIGLSTSSDSEMITQLLAYTPPQEQDDTPDWVARIKNLMKEA
PTAYSLLIMHRDVIYAVRDPYGNRPLCIGRLIPVSDINDKEKKTSETEGWVVSSESCSFL
SIGARYYREVLPGEIVEISRHNVQTLDIISRSEGNPVAFCIFEYVYFARPDSMFEDQMVY
TVRYRCGQQLAIEAPVDADLVSTVPESATPAALAYAGKCGLPYVEVLCKNRYVGRTFIQP
NMRLRQLGVAKKFGVLSDNFKGKRIVLVDDSIVRGNTISPIIKLLKESGAKEVHIRVASP
PIKYPCFMGINIPTKEELIANKPEFDHLAEYLGANSVVYLSVEGLVSSVQEGIKFKKQKE
KKHDIMIQENGNGLECFEKSGHCTACLTGKYPVELEW

# Metabolic_Enzyme_35_Number_of_Residues:
517

# Metabolic_Enzyme_35_Molecular_Weight:
57400

# Metabolic_Enzyme_35_Theoretical_pI:
6.74

# Metabolic_Enzyme_35_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
Function:  amidophosphoribosyltransferase activity
 ||
>>>
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  purine base metabolism
Process:  purine base biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_35_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_35_Specific_Function:
5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O

# Metabolic_Enzyme_35_Pathway:
map00230  Purine metabolism;
 map00251  Glutamate metabolism

# Metabolic_Enzyme_35_Reaction:
5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O

# Metabolic_Enzyme_35_Pfam_Domain_Function:
PF00310:GATase_2;
PF00156:Pribosyltran

# Metabolic_Enzyme_35_Signals:
None

# Metabolic_Enzyme_35_Transmembrane_Regions:
None

# Metabolic_Enzyme_35_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_35_EC_Link:
EC 2.4.2.14

# Metabolic_Enzyme_35_GenBank_ID_Protein:
219459

# Metabolic_Enzyme_35_SwissProt_ID:
PUR1_HUMAN (Q06203)

# Metabolic_Enzyme_35_swissprot_Name:
Not Available

# Metabolic_Enzyme_35_Genecard_id:
PPAT

# Metabolic_Enzyme_35_Geneatlas_id:
PPAT

# Metabolic_Enzyme_35_hgnc_id:
HGNC:9238

# Metabolic_Enzyme_35_PDB_ID:
Not Available

# Metabolic_Enzyme_35_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_35_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_35_Subcellular_Location:
Not Available

# Metabolic_Enzyme_35_Gene_Sequence:
>1554 bp
ATGGAGCTGGAGGAGTTGGGGATCCGAGAGGAATGTGGCGTGTTCGGGTGCATCGCCTCA
GGAGAGTGGCCCACGCAGCTGGATGTACCGCATGTGATCACTCTGGGACTCGTGGGGCTG
CAGCACCGGGGTCAGGAGAGTGCTGGTATTGTGACTAGTGATGGGAGTTCGGTGCCAACA
TTCAAATCACACAAGGGAATGGGTCTTGTAAATCACGTCTTTACTGAAGACAATTTGAAA
AAATTATATGTTTCAAATCTTGGAATTGGACACACCAGGTATGCCACCACAGGAAAATGT
GAACTAGAAAATTGTCAGCCCTTCGTTGTTGAAACACTTCATGGGAAGATAGCTGTGGCA
CATAATGGCGAATTGGTAAATGCTGCTCGATTAAGGAAAAAGCTTCTGCGTCATGGTATT
GGTCTGTCTACAAGTTCTGATAGTGAAATGATTACCCAGTTACTGGCGTATACCCCTCCT
CAGGAACAAGATGACACCCCAGACTGGGTAGCCAGGATTAAAAACTTGATGAAGGAAGCA
CCCACAGCATACTCCCTGCTTATAATGCACAGAGATGTTATTTATGCAGTACGAGATCCT
TATGGAAATCGTCCCTTATGCATTGGTCGTCTTATTCCAGTGTCTGATATAAATGACAAA
GAGAAAAAAACATCAGAAACAGAAGGATGGGTGGTGTCTTCAGAATCTTGTAGCTTCTTA
TCTATTGGTGCAAGATATTACCGTGAAGTCTTGCCTGGAGAAATTGTGGAAATATCCAGA
CACAATGTCCAAACTCTTGATATTATATCAAGGTCTGAAGGAAACCCAGTGGCTTTTTGT
ATCTTTGAATATGTTTATTTTGCAAGACCAGACAGTATGTTCGAAGACCAAATGGTTTAT
ACAGTAAGATACCGTTGTGGCCAGCAGCTAGCGATTGAAGCACCTGTGGATGCAGATTTG
GTTAGCACTGTTCCAGAATCTGCTACGCCTGCTGCTCTTGCTTACGCAGGAAAGTGTGGA
CTTCCATATGTGGAGGTGCTGTGTAAAAACCGGTATGTAGGGAGAACCTTCATTCAGCCA
AACATGAGGTTAAGACAACTTGGTGTTGCAAAAAAATTTGGAGTATTGTCAGACAACTTT
AAAGGCAAAAGAATTGTTCTTGTAGATGATTCAATTGTCAGAGGCAATACCATCTCACCT
ATAATAAAACTGCTCAAAGAATCTGGTGCAAAAGAGGTACACATTCGAGTAGCTTCACCA
CCAATTAAATATCCATGCTTCATGGGAATAAACATTCCTACAAAAGAAGAGCTCATTGCC
AATAAACCAGAATTTGATCACCTTGCAGAATATCTAGGAGCAAACAGTGTTGTGTATCTG
TCAGTAGAAGGACTGGTTTCATCTGTACAAGAAGGGATAAAGTTTAAAAAACAGAAAGAG
AAAAAGCACGATATTATGATCCAAGAAAATGGAAATGGTCTGGAATGTTTTGAAAAGAGT
GGTCATTGTACAGCTTGTCTCACTGGAAAATATCCTGTAGAATTAGAATGGTAG

# Metabolic_Enzyme_35_GenBank_ID_Gene:
D13757

# Metabolic_Enzyme_35_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_35_Locus:
4q12

# Metabolic_Enzyme_35_SNPs:
rs2660744; rs2271924; rs2412738; rs11538098; rs35420817; rs1042040; rs3796548; rs3733326; rs17086746; rs956275; rs6820922; rs2680758; rs6812041; rs6846937; rs3796542; rs7437329; rs13114104; rs2271923; rs13146014; rs6834696; rs6819534; rs13147824; rs1464286; rs6834384; rs6818340; rs11728068; rs6818283; rs1474178; rs1976815; rs12640212; rs3796540; rs4865101; rs7673373; rs11728110; rs12511049; rs6811652; rs6554356; rs1060472; rs1401911; rs6855372; rs1401912; rs6837413; rs4493603; rs13124065; rs3908150; rs3036860; rs1062466; rs1802777; rs34605681; rs34997894; rs34737334; rs3839138; rs35057235; rs10000147; rs34557332; rs35070617; rs35148002; rs28623333; rs34716907; rs35742146; rs2681327; rs3796541; rs28561902; rs2271925; rs13150137; rs35668718; rs3986276; rs35382139; rs34648210; rs35757795; rs28594232; rs10582002; rs3036882; rs3839137; rs3796539; rs35386544; rs35136233; rs5858379; rs7657711; rs13135046; rs34665020; rs35595440; rs10674802; rs5858380; rs10615588; rs3830557; rs33991118; rs3822000; rs6819040; rs34121369; rs28558611; rs2049090; rs12650250; rs6817674; rs3036929; rs35985431; rs7661712; rs10711201; rs3107324; rs34291736; rs35448595; rs3839136; rs2680759; rs11728195; rs4865100; rs35013647; rs10615589; rs10615306; rs5858378; rs34049939; rs34998854; rs5858377; rs35741626; rs2680760; rs11319799; rs34598008; rs35658616; rs10572187; rs2680757; rs28850125; rs36121369; rs34519551; rs34715669; rs10007966; rs10222686; rs11133439; rs11133442; rs11732985; rs11943048; rs12501502; rs12507183; rs13107124; rs13114481; rs13123301; rs13134963; rs1356787; rs1401908; rs1520024; rs1520025; rs1520026; rs1520030; rs17086755; rs17086758; rs17086759; rs2030363; rs2030364; rs2030365; rs2139512; rs2176785; rs2176786; rs2680755; rs2680756; rs2681325; rs2681326; rs34225999; rs34543011; rs34755867; rs3822001; rs4383672; rs4524447; rs4616819; rs4864583; rs6554355; rs6830518; rs6854326; rs6855041; rs7435941; rs7441274; rs7654543; rs7664841; rs7671868; rs7689163; rs7694047; rs9683679; rs9684143; rs9684298; rs9994575

# Metabolic_Enzyme_35_General_References:
8380692; 8106516

# Metabolic_Enzyme_35_References:
Not Available

# Metabolic_Enzyme_36_ID:
5515

# Metabolic_Enzyme_36_Name:
Aspartate aminotransferase, cytoplasmic

# Metabolic_Enzyme_36_Synonyms:
Transaminase A; Glutamate oxaloacetate transaminase 1

# Metabolic_Enzyme_36_Gene_Name:
GOT1

# Metabolic_Enzyme_36_Protein_Sequence:
>Aspartate aminotransferase, cytoplasmic
MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQK
IANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFL
ARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLEN
APEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWA
IRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPP
AQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGM
FSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ

# Metabolic_Enzyme_36_Number_of_Residues:
413

# Metabolic_Enzyme_36_Molecular_Weight:
46248

# Metabolic_Enzyme_36_Theoretical_pI:
7.01

# Metabolic_Enzyme_36_GO_Classification:
>>>
Function:  transaminase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_36_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_36_Specific_Function:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_36_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00272  Cysteine metabolism;
 map00330  Arginine and proline metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00401  Novobiocin biosynthesis;
 map00710  Carbon fixation;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_36_Reaction:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_36_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_36_Signals:
None

# Metabolic_Enzyme_36_Transmembrane_Regions:
None

# Metabolic_Enzyme_36_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_36_EC_Link:
EC 2.6.1.1

# Metabolic_Enzyme_36_GenBank_ID_Protein:
179067

# Metabolic_Enzyme_36_SwissProt_ID:
AATC_HUMAN (P17174)

# Metabolic_Enzyme_36_swissprot_Name:
Not Available

# Metabolic_Enzyme_36_Genecard_id:
GOT1

# Metabolic_Enzyme_36_Geneatlas_id:
GOT1

# Metabolic_Enzyme_36_hgnc_id:
HGNC:4432

# Metabolic_Enzyme_36_PDB_ID:
1AJS

# Metabolic_Enzyme_36_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_36_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_36_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_36_Gene_Sequence:
>1242 bp
ATGGCACCTCCGTCAGTCTTTGCCGAGGTTCCGCAGGCCCAGCCTGTCCTGGTCTTCAAG
CTCACTGCCGACTTCAGGGAGGATCCGGACCCCCGCAAGGTCAACCTGGGAGTGGGAGCA
TATCGCACGGATGACTGCCATCCCTGGGTTTTGCCAGTAGTGAAGAAAGTGGAGCAGAAG
ATTGCTAATGACAATAGCCTAAATCACGAGTATCTGCCAATCCTGGGCCTGGCTGAGTTC
CGGAGCTGTGCTTCTCGTCTTGCCCTTGGGGATGACAGCCCAGCACTCAAGGAGAAGCGG
GTAGGAGGTGTGCAATCTTTGGGGGGAACAGGTGCACTTCGAATTGGAGCTGATTTCTTA
GCGCGTTGGTACAATGGAACAAACAACAAGAACACACCTGTCTATGTGTCCTCACCAACC
TGGGAGAATCACAATGCTGTGTTTTCCGCTGCTGGTTTTAAAGACATTCGGTCCTATCGC
TACTGGGATGCAGAGAAGAGAGGATTGGACCTCCAGGGCTTCCTGAATGATCTGGAGAAT
GCTCCTGAGTTCTCCATTGTTGTCCTCCACGCCTGTGCACACAACCCAACTGGGATTGAC
CCAACTCCGGAGCAGTGGAAGCAGATTGCTTCTGTCATGAAGCACCGGTTTCTGTTCCCC
TTCTTTGACTCAGCCTATCAGGGCTTCGCATCTGGAAACCTGGAGAGAGATGCCTGGGCC
ATTCGCTATTTTGTGTCTGAAGGCTTCGAGTTCTTCTGTGCCCAGTCCTTCTCCAAGAAC
TTCGGGCTCTACAATGAGAGAGTCGGGAATCTGACTGTGGTTGGAAAAGAACCTGAGAGC
ATCCTGCAAGTCCTTTCCCAGATGGAGAAGATCGTGCGGATTACTTGGTCCAATCCCCCC
GCCCAGGGAGCACGAATTGTGGCCAGCACCCTCTCTAACCCTGAGCTCTTTGAGGAATGG
ACAGGTAATGTGAAGACAATGGCTGACCGGATTCTGACCATGAGATCTGAACTCAGGGCA
CGACTAGAAGCCCTCAAAACCCCTGGGACCTGGAACCACATCACTGATCAAATTGGCATG
TTCAGCTTCACTGGGTTGAACCCCAAGCAGGTTGAGTATCTGGTCAATGAAAAGCACATC
TACCTGCTGCCAAGTGGTCGAATCAACGTGAGTGGCTTAACCACCAAAAATCTAGATTAC
GTGGCCACCTCCATCCATGAAGCAGTCACCAAAATCCAGTGA

# Metabolic_Enzyme_36_GenBank_ID_Gene:
M37400

# Metabolic_Enzyme_36_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_36_Locus:
10q24.1-q25.1

# Metabolic_Enzyme_36_SNPs:
rs2234971; rs2641; rs11867; rs1126878; rs11190083; rs2862611; rs4328160; rs4919310; rs11813054; rs3793935; rs4919308; rs17111658; rs3750897; rs2275952; rs7906501; rs7918062; rs7067702; rs9971275; rs9971274; rs11190087; rs11594790; rs12571181; rs12249347; rs10883343; rs11819158; rs4353208; rs3763793; rs11190088; rs17569447; rs3793933; rs7921465; rs12253915; rs3793934; rs2494651; rs10883341; rs2862612; rs2490280; rs12768505; rs17111665; rs2862613; rs17569578; rs4567385; rs11815136; rs10883342; rs10748775; rs4919309; rs17491012; rs12253861; rs11190081; rs2862614; rs12217584; rs11815637; rs12766044; rs17111645; rs17111694; rs4919311; rs12411568; rs11557841; rs4564264; rs41290500; rs11557840; rs1126927; rs11190082; rs2642; rs1802509; rs1802508; rs41290498; rs34854950; rs12777843; rs35687189; rs11394746; rs34971146; rs34646712; rs35478605; rs34582301; rs3045656; rs12252840; rs35736782; rs11378738; rs7918037; rs41400447; rs7896693; rs5787336; rs9731375; rs35003844; rs11456562; rs11313874; rs12358477; rs10668892; rs12241455; rs41436049; rs5787337; rs9971276; rs35500142; rs35096443; rs11456561; rs2902275; rs7899976; rs13377085; rs12777646; rs10629267; rs12414885; rs35193236; rs11325628; rs12777641; rs34254460; rs1892505; rs12776735; rs12776369; rs4917866; rs12775973; rs11816599; rs6584274; rs33928164; rs10786543; rs7917808; rs11429814; rs35546038; rs10716499; rs35665184; rs11190090; rs34122561; rs2234894; rs10748774; rs10786545; rs11190080; rs11190094; rs1132364; rs11592057; rs11598504; rs17111699; rs17490682; rs2298315; rs2298316; rs2490281; rs2490283; rs2494652; rs2494653; rs2494654; rs2862610; rs34183428; rs3750896; rs3793931; rs3793932; rs4345898; rs4917862; rs4917864; rs4919307; rs7099391; rs7914408; rs7920356

# Metabolic_Enzyme_36_General_References:
1974457; 2241899

# Metabolic_Enzyme_36_References:
Not Available

# Metabolic_Enzyme_37_ID:
5509

# Metabolic_Enzyme_37_Name:
Tyrosine aminotransferase

# Metabolic_Enzyme_37_Synonyms:
L-tyrosine:2-oxoglutarate aminotransferase; TAT

# Metabolic_Enzyme_37_Gene_Name:
TAT

# Metabolic_Enzyme_37_Protein_Sequence:
>Tyrosine aminotransferase
MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAKKTFNPIRAIV
DNMKVKPNPNKTMISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGFLSSRE
EIASYYHCPEAPLEAKDVILTSGCSQAIDLCLAVLANPGQNILVPRPGFSLYKTLAESMG
IEVKLYNLLPEKSWEIDLKQLEYLIDEKTACLIVNNPSNPCGSVFSKRHLQKILAVAARQ
CVPILADEIYGDMVFSDCKYEPLATLSTDVPILSCGGLAKRWLVPGWRLGWILIHDRRDI
FGNEIRDGLVKLSQRILGPCTIVQGALKSILCRTPGEFYHNTLSFLKSNADLCYGALAAI
PGLRPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLVAEQSVHCLPATCFEYPNFIRVVI
TVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK

# Metabolic_Enzyme_37_Number_of_Residues:
454

# Metabolic_Enzyme_37_Molecular_Weight:
50400

# Metabolic_Enzyme_37_Theoretical_pI:
6.24

# Metabolic_Enzyme_37_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  transaminase activity
Function:  tyrosine transaminase activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-sulfur lyase activity
Function:  1-aminocyclopropane-1-carboxylate synthase activity
 ||
>>>
Process:  aromatic amino acid family metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  amino acid catabolism
Process:  aromatic amino acid family catabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_37_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_37_Specific_Function:
L-tyrosine + 2-oxoglutarate = 4- hydroxyphenylpyruvate + L-glutamate

# Metabolic_Enzyme_37_Pathway:
map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00401  Novobiocin biosynthesis;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_37_Reaction:
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate

# Metabolic_Enzyme_37_Pfam_Domain_Function:
PF00155:Aminotran_1_2;
PF07706:TAT_ubiq

# Metabolic_Enzyme_37_Signals:
None

# Metabolic_Enzyme_37_Transmembrane_Regions:
None

# Metabolic_Enzyme_37_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_37_EC_Link:
EC 2.6.1.5

# Metabolic_Enzyme_37_GenBank_ID_Protein:
36713

# Metabolic_Enzyme_37_SwissProt_ID:
ATTY_HUMAN (P17735)

# Metabolic_Enzyme_37_swissprot_Name:
Not Available

# Metabolic_Enzyme_37_Genecard_id:
TAT

# Metabolic_Enzyme_37_Geneatlas_id:
TAT

# Metabolic_Enzyme_37_hgnc_id:
HGNC:11573

# Metabolic_Enzyme_37_PDB_ID:
Not Available

# Metabolic_Enzyme_37_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_37_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_37_Subcellular_Location:
Not Available

# Metabolic_Enzyme_37_Gene_Sequence:
>1365 bp
ATGGACCCATACATGATTCAGATGAGCAGCAAAGGCAACCTCCCCTCAATTCTGGACGTG
CATGTCAACGTTGGTGGGAGAAGCTCTGTGCCGGGAAAAATGAAAGGCAGAAAGGCCAGG
TGGTCTGTGAGGCCCTCAGACATGGCCAAGAAAACTTTCAACCCCATCCGAGCCATTGTG
GACAACATGAAGGTGAAACCAAATCCAAACAAAACCATGATTTCCCTGTCCATTGGGGAC
CCTACTGTGTTTGGAAACCTGCCTACAGACCCTGAAGTTACCCAGGCAATGAAAGATGCC
CTGGACTCGGGCAAATATAATGGCTATGCCCCATCCATCGGCTTCCTATCCAGTCGGGAG
GAGATTGCTTCTTATTACCACTGTCCTGAGGCACCCCTAGAAGCTAAGGACGTCATTCTG
ACAAGTGGCTGCAGCCAAGCTATTGACCTTTGTTTAGCTGTGTTGGCCAACCCAGGGCAG
AACATCCTGGTTCCAAGACCTGGTTTCTCTCTCTACAAGACTCTGGCTGAGTCTATGGGA
ATTGAGGTCAAACTCTACAATTTGTTGCCAGAGAAATCTTGGGAAATTGACCTGAAACAA
CTGGAATATCTAATTGATGAAAAGACAGCTTGTCTCATTGTCAATAATCCATCAAACCCC
TGTGGGTCAGTGTTCAGCAAACGTCATCTTCAGAAGATTCTGGCAGTGGCTGCACGGCAG
TGTGTCCCCATCTTAGCTGATGAGATCTATGGAGACATGGTGTTTTCGGATTGCAAATAT
GAACCACTGGCCACCCTCAGCACCGATGTCCCCATCCTGTCCTGTGGAGGGCTGGCCAAG
CGCTGGCTGGTTCCTGGCTGGAGGTTGGGCTGGATCCTCATTCATGACCGAAGAGACATT
TTTGGCAATGAGATCCGAGATGGGCTGGTGAAGCTGAGTCAGCGCATTTTGGGACCCTGT
ACCATTGTCCAGGGAGCTCTGAAAAGCATCCTATGTCGCACCCCGGGAGAGTTTTACCAC
AACACTCTGAGCTTCCTCAAGTCCAATGCTGATCTCTGTTATGGGGCGTTGGCTGCCATC
CCTGGACTCCGGCCAGTCCGCCCTTCTGGGGCTATGTACCTCATGGTTGGAATTGAGATG
GAACATTTCCCAGAATTTGAGAACGATGTGGAGTTCACGGAGCGGTTAGTTGCTGAGCAG
TCTGTCCACTGCCTCCCAGCAACGTGCTTTGAGTACCCGAATTTCATCCGAGTGGTCATC
ACAGTCCCCGAGGTGATGATGCTGGAGGCGTGCAGCCGGATCCAGGAGTTCTGTGAGCAG
CACTACCATTGTGCTGAAGGCAGCCAGGAGGAGTGTGATAAATAG

# Metabolic_Enzyme_37_GenBank_ID_Gene:
X52520

# Metabolic_Enzyme_37_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_37_Locus:
16q22.1

# Metabolic_Enzyme_37_SNPs:
rs16973331; rs2432520; rs172650; rs2113223; rs2247603; rs2432519; rs9939332; rs13339247; rs13338868; rs16973337; rs1364210; rs1477386; rs2032921; rs3829537; rs2432521; rs3794689; rs2432522; rs11075889; rs8063455; rs1477387; rs9930543; rs11862798; rs16973344; rs34508506; rs12924334; rs11648913; rs2303226; rs3764308; rs34104038; rs36000068; rs35082722; rs34753286; rs2161674; rs8064108; rs1799881; rs3036400; rs3057106; rs8063793; rs34263853; rs1477388; rs34131262; rs1544808; rs1073060; rs12598228; rs1428834; rs1428835; rs2434886; rs4788809

# Metabolic_Enzyme_37_General_References:
1973834; 7908801; 7999802; 1357662

# Metabolic_Enzyme_37_References:
Not Available

# Metabolic_Enzyme_38_ID:
6005

# Metabolic_Enzyme_38_Name:
Gamma-glutamyltranspeptidase 1 precursor

# Metabolic_Enzyme_38_Synonyms:
Gamma- glutamyltransferase 1; GGT 1; CD224 antigen[Contains: Gamma- glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain]

# Metabolic_Enzyme_38_Gene_Name:
GGT1

# Metabolic_Enzyme_38_Protein_Sequence:
>Gammaglutamyltranspeptidase 1 precursor
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRD
GGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMFN
SSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALEN
KRTVIEQQPVLCEVFCRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKD
IQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSR
ESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISD
DTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNE
MDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTA
TALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTF
IAVVQAIVRTAGGWAAASDSRKGGEPAGY

# Metabolic_Enzyme_38_Number_of_Residues:
569

# Metabolic_Enzyme_38_Molecular_Weight:
61411

# Metabolic_Enzyme_38_Theoretical_pI:
7.14

# Metabolic_Enzyme_38_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring amino-acyl groups
Function:  gamma-glutamyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_38_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_38_Specific_Function:
Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive

# Metabolic_Enzyme_38_Pathway:
map00430  Taurine and hypotaurine metabolism;
 map00450  Selenoamino acid metabolism;
 map00460  Cyanoamino acid metabolism;
 map00480  Glutathione metabolism;
 map00590  Prostaglandin and leukotriene metabolism

# Metabolic_Enzyme_38_Reaction:
(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid

# Metabolic_Enzyme_38_Pfam_Domain_Function:
PF01019:G_glu_transpept

# Metabolic_Enzyme_38_Signals:
1-30

# Metabolic_Enzyme_38_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_38_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_38_EC_Link:
EC 2.3.2.2

# Metabolic_Enzyme_38_GenBank_ID_Protein:
183138

# Metabolic_Enzyme_38_SwissProt_ID:
GGT1_HUMAN (P19440)

# Metabolic_Enzyme_38_swissprot_Name:
Not Available

# Metabolic_Enzyme_38_Genecard_id:
GGT1

# Metabolic_Enzyme_38_Geneatlas_id:
GGT1

# Metabolic_Enzyme_38_hgnc_id:
HGNC:4250

# Metabolic_Enzyme_38_PDB_ID:
Not Available

# Metabolic_Enzyme_38_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_38_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_38_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_38_Gene_Sequence:
>1710 bp
ATGAAGAAGAAGTTAGTGGTGCTGGGCCTGCTGGCCGTGGTCCTGGTGCTGGTCATTGTC
GGCCTCTGTCTCTGGCTGCCCTCAGCCTCCAAGGAACCTGACAACCATGTGTACACCAGG
GCTGCCGTGGCCGCGGATGCCAAGCAGTGCTCGAAGATTGGGAGGGATGCACTGCGGGAC
GGTGGCTCTGCGGTGGATGCAGCCATTGCAGCCCTGTTGTGTGTGGGGCTCATGAATGCC
CACAGCATGGGCATCGGGGGTGGCCTCTTCCTCACCATCTACAACAGCACCACACGAAAA
GCTGAGGTCATCAACGCCCGCGAGGTGGCCCCCAGGCTGGCCTTTGCCACCATGTTCAAC
AGCTCGGAGCAGTCCCAGAAGGGGGGGCTGTCGGTGGCGGTGCCTGGGGAGATCCGAGGC
TATGAGCTGGCACACCAGCGGCATGGGCGGCTGCCCTGGGCTCGCCTCTTCCAGCCCAGC
ATCCAGCTGGCCCGCCAGGGCTTCCCCGTGGGCAAGGGCTTGGCGGCAGCCCTGGAAAAC
AAGCGGACCGTCATCGAGCAGCAGCCTGTCTTGTGTGAGGTGTTCTGCCGGGATAGAAAG
GTGCTTCGGGAGGGGGAGAGACTGACCCTGCCGCAGCTGGCTGACACCTACGAGACGCTG
GCCATCGAGGGTGCCCAGGCCTTCTACAACGGCAGCCTCACGGCCCAGATTGTGAAGGAC
ATCCAGGCGGCCGGGGGCATTGTGACAGCTGAGGACCTGAACAACTACCGTGCTGAGCTG
ATCGAGCACCCGCTGAACATCAGCCTGGGAGACGCGGTGCTGTACATGCCCAGTGCGCCG
CTCAGCGGGCCCGTGCTGGCCCTCATCCTCAACATCCTCAAAGGGTACAACTTCTCCCGG
GAGAGCGTGGAGAGCCCCGAGCAGAAGGGCCTGACGTACCACCGCATCGTAGAGGCTTTC
CGGTTTGCCTACGCCAAGAGGACCCTGCTTGGGGACCCCAAGTTTGTGGATGTGACTGAG
GTGGTCCGCAACATGACCTCCGAGTTCTTCGCTGCCCAGCTCCGGGCCCAGATCTCTGAC
GACACCACTCACCCGATCTCCTACTACAAGCCCGAGTTCTACACGCCGGATGACGGGGGC
ACTGCTCACCTGTCTGTCGTCGCAGAGGACGGCAGTGCTGTGTCCGCCACCAGCACCATC
AACCTCTACTTTGGCTCCAAGGTCCGCTCCCCGGTCAGCGGGATCCTGTTCAATAATGAA
ATGGACGACTTCAGCTCTCCCAGCATCACCAACGAGTTTGGGGTACCCCCCTCACCTGCC
AATTTCATCCAGCCAGGGAAGCAGCCGCTCTCGTCCATGTGCCCGACGATCATGGTGGGC
CAGGACGGCCAGGTCCGGATGGTGGTGGGAGCTGCTGGGGGCACACAGATCACCACGGCC
ACTGCACTGGCCATCATCTACAACCTCTGGTTCGGCTATGACGTGAAGCGGGCCGTGGAG
GAGCCCCGGCTGCACAACCAGCTTCTGCCCAACGTCACGACAGTGGAGAGAAACATTGAC
CAGGCAGTGACTGCAGCCCTGGAGACCCGGCACCATCACACCCAGATCGCGTCCACCTTC
ATCGCTGTGGTGCAAGCCATCGTCCGCACGGCTGGTGGCTGGGCAGCTGCCTCGGACTCC
AGGAAAGGCGGGGAGCCTGCCGGCTACTGA

# Metabolic_Enzyme_38_GenBank_ID_Gene:
J04131

# Metabolic_Enzyme_38_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_38_Locus:
22q11.23

# Metabolic_Enzyme_38_SNPs:
rs2330837; rs3895576; rs2330838; rs2017869; rs2330795; rs2073398; rs9624507; rs2006092; rs6519520; rs5751901; rs6519519; rs7284489; rs3788375; rs7292010; rs5760495; rs4049889; rs2006094; rs5760494; rs2001180; rs6004192; rs5751905; rs5760493; rs2006227; rs9624506; rs2005589; rs4822516; rs5751904; rs2073397; rs5760492; rs2076999; rs3859862; rs2010657; rs2003757; rs16990490; rs8138050; rs4049918; rs9608300; rs2017188; rs1807629; rs2330797; rs4822517; rs6004195; rs7286626; rs3747117; rs5760491; rs2330805; rs9624510; rs743371; rs3876104; rs4820600; rs5751902; rs5760490; rs6004193; rs6004194; rs8135987; rs8139070; rs5751909; rs5751910; rs9306396; rs9612676; rs5760505; rs2330848; rs5760499; rs5760497; rs5760504; rs4049843; rs9680722; rs2330841; rs524033; rs11913233; rs9680724; rs4049855; rs380131; rs3934421; rs4822523; rs5760500; rs6004203; rs3901297; rs5760498; rs391837; rs5751908; rs9680612; rs3895577; rs4822520; rs4049869; rs3895575; rs7511507; rs7511598; rs389004; rs2236626; rs7285339; rs2330842; rs4049882; rs4049829; rs28621555; rs2330836; rs3966247; rs12159765; rs4049897; rs4049881; rs9612682; rs2330843; rs4049844; rs4049883; rs2330844; rs5751900; rs2330830; rs12169166; rs4049900; rs2330818; rs2330826; rs9624503; rs3966256; rs9612663; rs3966255; rs3895580; rs4049911; rs2877222; rs2330801; rs3033885; rs9624509; rs6004196; rs4049914; rs2330835; rs1832359; rs28509371; rs4049896; rs2298391; rs2330825; rs9624505; rs2877224; rs4049885; rs2330811; rs4049917; rs2330806; rs3876101; rs3887791; rs12484586; rs4049890; rs8139074; rs3895578; rs28550867; rs4049905; rs4049925; rs3966259; rs673673; rs753462; rs4049899; rs2330813; rs8138031; rs4049895; rs28605797; rs3966263; rs3876105; rs9612666; rs2330808; rs2330832; rs2076800; rs13057657; rs3033738; rs3966257; rs2330803; rs2330815; rs4049912; rs3033744; rs2330810; rs2330800; rs3895574; rs6004191; rs8137090; rs2330807; rs2330834; rs4049913; rs28449741; rs2330827; rs3966260; rs9624504; rs2330817; rs9612671; rs4049903; rs2877221; rs5751903; rs2330824; rs2079567; rs2330796; rs4049898; rs11913684; rs2877225; rs2330831; rs4049891; rs4049915; rs2330812; rs4049910; rs4049916; rs4049908; rs12106564; rs3876100; rs3859863; rs3032936; rs9624508; rs4049901; rs12163146; rs4049924; rs4049906; rs2330819; rs9612664; rs3788376; rs3895579; rs2330822; rs2330804; rs2330823; rs2077120; rs2089350; rs2330814; rs2006093; rs4049904; rs9608301; rs3865759; rs2330799; rs3966258; rs28566494; rs2330820; rs3876103; rs2330802; rs4049926; rs3894886; rs3966262; rs2079568; rs2330816; rs2330809; rs2330798; rs2877223; rs4049902; rs8139073; rs4049865; rs4049850; rs4049857; rs2877228; rs28663139; rs4049837; rs4049873; rs4049867; rs4049860; rs28545702; rs34659550; rs3865654; rs4049863; rs28377326; rs3865651; rs4535160; rs4049839; rs11913428; rs2096530; rs28366457; rs4049828; rs3865649; rs9608303; rs4049861; rs6004202; rs2330853; rs6004200; rs4049833; rs10602389; rs9624512; rs4049875; rs2330849; rs3865659; rs3966245; rs2330852; rs12167273; rs4049847; rs2096529; rs4049868; rs7287997; rs4049880; rs4049835; rs3865653; rs11703306; rs4049878; rs2330846; rs3865657; rs35411004; rs2330850; rs5760509; rs12168759; rs9620404; rs4049870; rs9612673; rs5760510; rs4049836; rs28441370; rs12170528; rs4049849; rs4049827; rs4049851; rs3865655; rs4049872; rs3865650; rs6004205; rs5751911; rs4049858; rs4049879; rs2877229; rs2330845; rs6004201; rs12159496; rs4426615; rs4049838; rs2877230; rs12168762; rs28418841; rs4049877; rs3876106; rs28477676; rs5760503; rs3938847; rs9620400; rs2330847; rs4049842; rs28402861; rs28718168; rs3865658; rs4049856; rs2877227; rs12166510; rs4049832; rs7284160; rs2105500; rs11416248; rs493075; rs2877231; rs3966265; rs2330851; rs3966264; rs6004198; rs3897519; rs4049864; rs4049854; rs4049830; rs3865656; rs2845424; rs9612672; rs5751465; rs4049871; rs11912608; rs9620401; rs2330840; rs4049859; rs28451181; rs4049834; rs4049862; rs9612679; rs3034881; rs4049874; rs3865652; rs35525727; rs3035043; rs12158857; rs2330854; rs35882418; rs5760483; rs11318518; rs11913638; rs12158094; rs16978739; rs2070477; rs2154611; rs4820599; rs5760485; rs5760488; rs7287904; rs737128; rs743369; rs743370; rs762286; rs874852; rs928785; rs9608299; rs9830

# Metabolic_Enzyme_38_General_References:
2904146; 2907498; 2563599; 2568315; 1968061; 1378736; 7689219; 10591208; 2896486; 10392451; 19463; 2900635; 8095045; 7759490; 7673200; 8827453

# Metabolic_Enzyme_38_References:
Not Available

# Metabolic_Enzyme_39_ID:
5943

# Metabolic_Enzyme_39_Name:
Glutamine synthetase

# Metabolic_Enzyme_39_Synonyms:
Glutamate--ammonia ligase; GS

# Metabolic_Enzyme_39_Gene_Name:
GLUL

# Metabolic_Enzyme_39_Protein_Sequence:
>Glutamine synthetase
MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEW
NFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRI
MDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHY
RACLYAGVKIAGTNAEVMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDP
KPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRL
TGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCL
LNETGDEPFQYKN

# Metabolic_Enzyme_39_Number_of_Residues:
373

# Metabolic_Enzyme_39_Molecular_Weight:
42065

# Metabolic_Enzyme_39_Theoretical_pI:
6.88

# Metabolic_Enzyme_39_GO_Classification:
>>>
Function:  acid-ammonia (or amide) ligase activity
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  acid-ammonia (or amide) ligase activity
Function:  ammonia ligase activity
Function:  glutamate-ammonia ligase activity
 ||
>>>
Process:  nitrogen compound metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
Process:  glutamine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_39_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_39_Specific_Function:
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine

# Metabolic_Enzyme_39_Pathway:
map00251  Glutamate metabolism;
 map00550  Peptidoglycan biosynthesis;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_39_Reaction:
ATP + L-glutamate + ammonia = ADP + phosphate + L-glutamine

# Metabolic_Enzyme_39_Pfam_Domain_Function:
PF00120:Gln-synt_C;
PF03951:Gln-synt_N

# Metabolic_Enzyme_39_Signals:
None

# Metabolic_Enzyme_39_Transmembrane_Regions:
None

# Metabolic_Enzyme_39_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_39_EC_Link:
EC 6.3.1.2

# Metabolic_Enzyme_39_GenBank_ID_Protein:
31833

# Metabolic_Enzyme_39_SwissProt_ID:
GLNA_HUMAN (P15104)

# Metabolic_Enzyme_39_swissprot_Name:
Not Available

# Metabolic_Enzyme_39_Genecard_id:
GLUL

# Metabolic_Enzyme_39_Geneatlas_id:
GLUL

# Metabolic_Enzyme_39_hgnc_id:
HGNC:4341

# Metabolic_Enzyme_39_PDB_ID:
Not Available

# Metabolic_Enzyme_39_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_39_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_39_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_39_Gene_Sequence:
>1122 bp
ATGACCACCTCAGCAAGTTCCCACTTAAATAAAGGCATCAAGCAGGTGTACATGTCCCTG
CCTCAGGGTGAGAAAGTCCAGGCCATGTATATCTGGATCGATGGTACTGGAGAAGGACTG
CGCTGCAAGACCCGGACCCTGGACAGTGAGCCCAAGTGTGTGGAAGAGTTGCCTGAGTGG
AATTTCGATGGCTCCAGTACTTTACAGTCTGAGGGTTCCAACAGTGACATGTATCTCGTG
CCTGCTGCCATGTTTCGGGACCCCTTCCGTAAGGACCCTAACAAGCTGGTGTTATGTGAA
GTTTTCAAGTACAATCGAAGGCCTGCAGAGACCAATTTGAGGCACACCTGTAAACGGATA
ATGGACATGGTGAGCAACCAGCACCCCTGGTTTGGCATGGAGCAGGAGTATACCCTCATG
GGGACAGATGGGCACCCCTTTGGTTGGCCTTCCAACGGCTTCCCAGGGCCCCAGGGTCCA
TATTACTGTGGTGTGGGAGCAGACAGAGCCTATGGCAGGGACATCGTGGAGGCCCATTAC
CGGGCCTGCTTGTATGCTGGAGTCAAGATTGCGGGGACTAATGCCGAGGTCATGCCTGCC
CAGTGGGAATTTCAGATTGGACCTTGTGAAGGAATCAGCATGGGAGATCATCTCTGGGTG
GCCCGTTTCATCTTGCATCGTGTGTGTGAAGACTTTGGAGTGATAGCAACCTTTGATCCT
AAGCCCATTCCTGGGAACTGGAATGGTGCAGGCTGCCATACCAACTTCAGCACCAAGGCC
ATGCGGGAGGAGAATGGTCTGAAGTACATCGAGGAGGCCATTGAGAAACTAAGCAAGCGG
CACCAGTACCACATCCGTGCCTATGATCCCAAGGGAGGCCTGGACAATGCCCGACGTCTA
ACTGGATTCCATGAAACCTCCAACATCAACGACTTTTCTGGTGGTGTAGCCAATCGTAGC
GCCAGCATACGCATTCCCCGGACTGTTGGCCAGGAGAAGAAGGGTTACTTTGAAGATCGT
CGCCCCTCTGCCAACTGCGACCCCTTTTCGGTGACAGAAGCCCTCATCCGCACGTGTCTT
CTCAATGAAACCGGCGATGAGCCCTTCCAGTACAAAAATTAA

# Metabolic_Enzyme_39_GenBank_ID_Gene:
Y00387

# Metabolic_Enzyme_39_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_39_Locus:
1q31

# Metabolic_Enzyme_39_SNPs:
rs1058111; rs912900; rs9347; rs912901; rs4075941; rs4652704; rs7539686; rs7734; rs3895340; rs4652705; rs912902; rs12136955; rs12403634; rs4075940; rs1058788; rs16828882; rs8762; rs7543200; rs3795487; rs2296520; rs2296519; rs10494546; rs17462824; rs12735664; rs11577936; rs2296521; rs6691339; rs11577698; rs2296523; rs11577696; rs10797771; rs4652707; rs16858921; rs4652706; rs11585457; rs2296522; rs10429835; rs4517308; rs10797770; rs11541591; rs17855559; rs17852995; rs35378126; rs17852994; rs6666230; rs6684136; rs6679250; rs34809780; rs12082312; rs36115491; rs7548303; rs1058744; rs3199511; rs12757803; rs17509341; rs1058806; rs6703479; rs8527; rs1058719; rs10535077; rs4110992; rs6699943; rs35747237; rs35275813; rs35161314; rs35268520; rs10911069; rs10458354; rs34444584; rs34239448; rs12088820; rs3028837; rs35750497; rs1001403; rs10911070; rs10911071; rs11576932; rs12039934; rs12568730; rs12733426; rs12736387; rs12756106; rs17509572; rs17509621; rs1925829; rs2038891; rs2068781; rs2148030; rs4652708; rs6424853; rs6667958; rs6674281; rs6684297; rs6698722; rs7549329; rs7549498; rs7551829

# Metabolic_Enzyme_39_General_References:
2888076; 1681907; 7909780; 12387715

# Metabolic_Enzyme_39_References:
Not Available

# Metabolic_Enzyme_40_ID:
8804

# Metabolic_Enzyme_40_Name:
Gamma-glutamyl hydrolase precursor

# Metabolic_Enzyme_40_Synonyms:
Gamma-Glu-X carboxypeptidase; Conjugase; GH

# Metabolic_Enzyme_40_Gene_Name:
GGH

# Metabolic_Enzyme_40_Protein_Sequence:
>Gammaglutamyl hydrolase precursor
MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASY
VKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQ
SFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTE
LLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYG
VQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQF
SPIYTGNISSFQQCYIFD

# Metabolic_Enzyme_40_Number_of_Residues:
318

# Metabolic_Enzyme_40_Molecular_Weight:
35965

# Metabolic_Enzyme_40_Theoretical_pI:
7.14

# Metabolic_Enzyme_40_GO_Classification:
>>>
 Function:  catalytic activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_40_General_Function:
Not Available

# Metabolic_Enzyme_40_Specific_Function:
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates

# Metabolic_Enzyme_40_Pathway:
map00790  Folate biosynthesis

# Metabolic_Enzyme_40_Reaction:
Hydrolysis of a gamma-glutamyl bond

# Metabolic_Enzyme_40_Pfam_Domain_Function:
PF07722:Peptidase_C26

# Metabolic_Enzyme_40_Signals:
1-24

# Metabolic_Enzyme_40_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_40_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_40_EC_Link:
EC 3.4.19.9

# Metabolic_Enzyme_40_GenBank_ID_Protein:
2951931

# Metabolic_Enzyme_40_SwissProt_ID:
GGH_HUMAN (Q92820)

# Metabolic_Enzyme_40_swissprot_Name:
Not Available

# Metabolic_Enzyme_40_Genecard_id:
GGH

# Metabolic_Enzyme_40_Geneatlas_id:
GGH

# Metabolic_Enzyme_40_hgnc_id:
HGNC:4248

# Metabolic_Enzyme_40_PDB_ID:
1L9X

# Metabolic_Enzyme_40_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_40_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_40_Subcellular_Location:
Secreted protein; extracellular space. Lysosome. Melanosome. Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Metabolic_Enzyme_40_Gene_Sequence:
>957 bp
ATGGCCAGTCCGGGCTGCCTGCTGTGCGTGCTGGGCCTGCTACTCTGCGGGGCGGCGAGC
CTCGAGCTGTCTAGACCCCACGGCGACACCGCCAAGAAGCCCATCATCGGAATATTAATG
CAAAAATGCCGTAATAAAGTCATGAAAAACTATGGAAGATACTATATTGCTGCGTCCTAT
GTAAAGTACTTGGAGTCTGCAGGTGCGAGAGTTGTACCAGTAAGGCTGGATCTTACAGAG
AAAGACTATGAAATACTTTTCAAATCTATTAATGGAATCCTTTTCCCTGGAGGAAGTGTT
GACCTCAGACGCTCAGATTATGCTAAAGTGGCCAAAATATTTTATAACTTGTCCATACAG
AGTTTTGATGATGGAGACTATTTTCCTGTGTGGGGCACATGCCTTGGATTTGAAGAGCTT
TCACTGCTGATTAGTGGAGAGTGCTTATTAACTGCCACAGATACTGTTGACGTGGCAATG
CCGCTGAACTTCACTGGAGGTCAATTGCACAGCAGAATGTTCCAGAATTTTCCTACTGAG
TTGTTGCTGTCATTAGCAGTAGAACCTCTGACTGCCAATTTCCATAAGTGGAGCCTCTCC
GTGAAGAATTTTACAATGAATGAAAAGTTAAAGAAGTTTTTCAATGTCTTAACTACAAAT
ACAGATGGCAAGATTGAGTTTATTTCAACAATGGAAGGATATAAGTATCCAGTATATGGT
GTCCAGTGGCATCCAGAGAAAGCACCTTATGAGTGGAAGAATTTGGATGGCATTTCCCAT
GCACCTAATGCTGTGAAAACCGCATTTTATTTAGCAGAGTTTTTTGTTAATGAAGCTCGG
AAAAACAACCATCATTTTAAATCTGAATCTGAAGAGGAGAAAGCATTGATTTATCAGTTC
AGTCCAATTTATACTGGAAATATTTCTTCATTTCAGCAATGTTACATATTTGATTGA

# Metabolic_Enzyme_40_GenBank_ID_Gene:
U55206

# Metabolic_Enzyme_40_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_40_Locus:
8q12.3

# Metabolic_Enzyme_40_SNPs:
rs1800909; rs11545078; rs13270305; rs11786893; rs17279558; rs1031552; rs10957267; rs11990678; rs11995525; rs10957268; rs3780126; rs3780130; rs2736683; rs12681874; rs4617146; rs12677953; rs9298071; rs2305558; rs16930092; rs11786957; rs12541873; rs3780128; rs7839267; rs7010484; rs3780127; rs16930090; rs3780129; rs12335094; rs6998383; rs12676348; rs11985462; rs12541370; rs12682204; rs7839874; rs11776425; rs16930089; rs3824333; rs12678042; rs12677972; rs13248452; rs17194931; rs1963949; rs13273611; rs12675369; rs13268472; rs1124409; rs719236; rs719235; rs4279586; rs11988534; rs4346986; rs3758147; rs3758149; rs2736681; rs12544045; rs10464903; rs11545076; rs2736676; rs11545079; rs15074; rs35885634; rs2736680; rs4310197; rs34568404; rs34099334; rs33977289; rs35671428; rs34800375; rs34231825; rs34565343; rs35231716; rs3837214; rs4987171; rs35900090; rs34415067; rs36031838; rs12548729; rs1985361; rs34822356; rs35916001; rs10671033; rs13439103; rs7839216; rs35572611; rs12682385; rs34351525; rs35127436; rs4317561; rs4521747; rs4581048; rs4737625; rs4404907; rs34007125; rs35945381; rs2736682; rs35599101; rs2736679; rs34561811; rs2736677; rs2736675; rs35535527; rs4590435; rs2736678; rs10528240; rs10106324; rs10106587; rs10464904; rs10464905; rs10504362; rs10957266; rs11993344; rs12541122; rs12547126; rs12548933; rs12682112; rs17279320; rs17279355; rs6998134; rs7002066; rs7003413; rs7004312; rs930840

# Metabolic_Enzyme_40_General_References:
8816764; 10570974

# Metabolic_Enzyme_40_References:
Not Available

# Metabolic_Enzyme_41_ID:
8813

# Metabolic_Enzyme_41_Name:
Glutamine-dependent NAD(+) synthetase

# Metabolic_Enzyme_41_Synonyms:
NAD(+synthase [glutamine-hydrolyzing]; NAD(+synthetase 1

# Metabolic_Enzyme_41_Gene_Name:
NADSYN1

# Metabolic_Enzyme_41_Protein_Sequence:
>Glutaminedependent NAD+ synthetase
MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYES
DTLLHSFQVLAALVESPVTQDIICDVGMPVMHRNVRYNCRVIFLNRKILLIRPKMALANE
GNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWT
PHSPHIDMGLDGVEIITNASGSHHVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRL
YYDGCAMIAMNGSVFAQGSQFSLDDVEVLTATLDLEDVRSYRAEISSRNLAASRASPYPR
VKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGV
DSAATACLIYSMCCQVCEAVRSGNEEVLADVRTIVNQISYTPQDPRDLCGRILTTCYMAS
KNSSQETCTRARELAQQIGSHHISLNIDPAVKAVMGIFSLVTGKSPLFAAHGGSSRENLA
LQNVQARIRMVLAYLFAQLSLWSRGVHGGLLVLGSANVDESLLGYLTKYDCSSADINPIG
GISKTDLRAFVQFCIQRFQLPALQSILLAPATAELEPLADGQVSQTDEEDMGMTYAELSV
YGKLRKVAKMGPYSMFCKLLGMWRHICTPRQVADKVKRFFSKYSMNRHKMTTLTPAYHAE
NYSPEDNRFDLRPFLYNTSWPWQFRCIENQVLQLERAEPQSLDGVD

# Metabolic_Enzyme_41_Number_of_Residues:
706

# Metabolic_Enzyme_41_Molecular_Weight:
79295

# Metabolic_Enzyme_41_Theoretical_pI:
6.46

# Metabolic_Enzyme_41_GO_Classification:
>>>
 Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Function:  NAD+ synthase (glutamine-hydrolyzing) activity
 ||
>>>
 Process:  nitrogen compound metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  cofactor metabolism
Process:  coenzyme metabolism
Process:  coenzyme biosynthesis
Process:  pyridine nucleotide biosynthesis
Process:  NAD biosynthesis
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_41_General_Function:
Coenzyme transport and metabolism

# Metabolic_Enzyme_41_Specific_Function:
ATP + deamido-NAD(+) + L-glutamine + H(2)O = AMP + diphosphate + NAD(+) + L-glutamate

# Metabolic_Enzyme_41_Pathway:
map00251  Glutamate metabolism
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_41_Reaction:
ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate

# Metabolic_Enzyme_41_Pfam_Domain_Function:
PF00795:CN_hydrolase
PF02540:NAD_synthase

# Metabolic_Enzyme_41_Signals:
Not Available

# Metabolic_Enzyme_41_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_41_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_41_EC_Link:
EC 6.3.5.1

# Metabolic_Enzyme_41_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_41_SwissProt_ID:
NADE1_HUMAN (Q6IA69)

# Metabolic_Enzyme_41_swissprot_Name:
Not Available

# Metabolic_Enzyme_41_Genecard_id:
NADSYN1

# Metabolic_Enzyme_41_Geneatlas_id:
NADSYN1

# Metabolic_Enzyme_41_hgnc_id:
HGNC:29832

# Metabolic_Enzyme_41_PDB_ID:
Not Available

# Metabolic_Enzyme_41_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_41_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_41_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_41_Gene_Sequence:
Not Available

# Metabolic_Enzyme_41_GenBank_ID_Gene:
AB091316

# Metabolic_Enzyme_41_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_41_Locus:
11q13.4

# Metabolic_Enzyme_41_SNPs:
rs2276360; rs7121106; rs12282060; rs35007971; rs2186778; rs2276354; rs11540018; rs1792226; rs4944957; rs732934; rs1792231; rs1540127; rs1790340; rs4402322; rs3794064; rs1893058; rs1792227; rs1790341; rs4944997; rs7129044; rs4944958; rs3814734; rs3814731; rs4944959; rs1792225; rs1790373; rs4944075; rs3794060; rs2017686; rs2276358; rs1792224; rs1790344; rs4423214; rs949178; rs1790339; rs1792316; rs4944955; rs1792229; rs2276361; rs4435028; rs1790343; rs2040323; rs4616066; rs4944956; rs1619577; rs3794062; rs3794057; rs1792235; rs7114525; rs2276362; rs3814733; rs12575605; rs2298776; rs3794067; rs7938885; rs1629220; rs3794061; rs12577807; rs10898203; rs3819215; rs11600569; rs1792234; rs6592154; rs7129099; rs12800438; rs10898210; rs12574206; rs4944076; rs3794065; rs10898193; rs4944998; rs3794068; rs2276353; rs7952035; rs3794059; rs12277408; rs4944062; rs2282619; rs12575622; rs10898211; rs7944926; rs7120029; rs7935125; rs2282618; rs12286616; rs11233747; rs12576621; rs3831470; rs7950778; rs2298773; rs12281892; rs7123973; rs4944979; rs10898191; rs12295554; rs12274363; rs7948770; rs2282617; rs3814732; rs11600355; rs7130038; rs7948898; rs2298772; rs12790558; rs10160536; rs12270619; rs7114825; rs1792319; rs12792306; rs3829251; rs12808368; rs10160376; rs1792315; rs11233789; rs12273154; rs7131218; rs41395047; rs1792233; rs11602942; rs4944063; rs4488226; rs7949129; rs7129788; rs11233901; rs4944999; rs12286569; rs3794063; rs3838792; rs11233754; rs2282620; rs12286997; rs10898201; rs1629304; rs10898186; rs2298775; rs3794066; rs11233746; rs12278461; rs12285168; rs3819214; rs12807718; rs2282621; rs3763860; rs7130479; rs12275636; rs12280406; rs4944064; rs12574554; rs10898200; rs11233933; rs4944996; rs12280295; rs12288906; rs12785878; rs751389; rs2002064; rs11546509; rs11600860; rs11606611; rs2002063; rs11606631; rs11606612; rs7950441; rs35588716; rs35279643; rs3192486; rs34989018; rs12282141; rs12791871; rs10466717; rs7117435; rs11233810; rs11233800; rs4414250; rs34354702; rs35349037; rs35043114; rs11233896; rs7950697; rs7123872; rs35799712; rs35611530; rs12795432; rs35482873; rs34432098; rs7117446; rs35741576; rs10625411; rs12795438; rs12275635; rs12792622; rs7943296; rs12269986; rs34316417; rs35072948; rs11233744; rs11354381; rs2298774; rs12793224; rs1123007; rs3838794; rs12285566; rs2276357; rs7120978; rs12793235; rs10751102; rs11825517; rs1894101; rs35877645; rs34693567; rs12806844; rs7938224; rs28823295; rs7130315; rs10717036; rs2511010; rs10667241; rs12284909; rs28722015; rs11451410; rs3838793; rs7947153; rs34147368; rs35670335; rs12800594; rs1790342; rs34130258; rs12790010; rs35262706; rs12275637; rs11820509; rs35809668; rs35106262; rs3763859; rs36007316; rs35713855; rs11233919; rs10160252; rs11233871; rs34587279; rs10466698; rs12800580; rs2276359; rs35816375; rs12793040; rs7946818; rs12274022; rs34267425; rs12225516; rs34448346; rs34566508; rs11233750; rs35149281; rs11233897; rs12224205; rs2276355; rs12289358; rs1052193; rs7113783; rs7114971; rs753352; rs28898287; rs34753851; rs12794668; rs732935; rs7107444; rs35150568; rs5792561; rs34591259; rs11607157; rs11233902; rs34864556; rs35880452; rs12794647; rs12789751; rs34966057; rs12278475; rs36056023; rs11233868; rs12807827; rs1626291; rs35865105; rs11233947; rs1002171; rs1044482; rs10792743; rs10898223; rs11233977; rs11823940; rs11824413; rs12283114; rs12283185; rs12283407; rs12289036; rs12289074; rs12360674; rs12422045; rs12573951; rs17161531; rs17161576; rs1790334; rs2155425; rs2155428; rs2186777; rs2851691; rs2851692; rs2851693; rs3750997; rs4245442; rs4316537; rs4944946; rs4944949; rs4945007; rs4945008; rs7926054; rs7928249; rs7940244; rs7950584; rs7950649

# Metabolic_Enzyme_41_General_References:
12547821

# Metabolic_Enzyme_41_References:
Not Available

# Metabolic_Enzyme_42_ID:
8876

# Metabolic_Enzyme_42_Name:
CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase

# Metabolic_Enzyme_42_Synonyms:
Not Available

# Metabolic_Enzyme_42_Gene_Name:
CAD

# Metabolic_Enzyme_42_Protein_Sequence:
>CAD protein Includes: Glutaminedependent carbamoylphosphate synthase
MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNY
GIPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVD
TRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILA
LDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVL
SEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVE
TDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEA
TAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAI
KALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQT
ALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQ
AQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEI
EYEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQTLNDREYQLLRQTAIKVTQHLG
IVGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRN
SVTGGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKAL
RMVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRM
KRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAV
KQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQ
QLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLP
NNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQT
VGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAV
ASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFN
LQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVG
VKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIG
SYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSI
LEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEAL
GQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMV
CAMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLN
ETFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEE
ILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVI
DCFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIF
HLPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVL
VPPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASD
PGLPAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHS
LVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSF
AAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRR
PVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVS
LRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEA
CFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLAT
VLGRF

# Metabolic_Enzyme_42_Number_of_Residues:
2225

# Metabolic_Enzyme_42_Molecular_Weight:
242987

# Metabolic_Enzyme_42_Theoretical_pI:
6.42

# Metabolic_Enzyme_42_GO_Classification:
>>>
 Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  carbamoyl-phosphate synthase activity
Function:  aspartate carbamoyltransferase activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  carboxyl- and carbamoyltransferase activity
Function:  binding
Function:  amine binding
Function:  amino acid binding
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
 Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
Process:  urea cycle intermediate metabolism
Process:  arginine metabolism
Process:  arginine biosynthesis
Process:  nitrogen compound metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  pyrimidine base metabolism
Process:  pyrimidine base biosynthesis
Process:  'de novo' pyrimidine base biosynthesis
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
 Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_42_General_Function:
Amino acid transport and metabolism

# Metabolic_Enzyme_42_Specific_Function:
This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase)

# Metabolic_Enzyme_42_Pathway:
map00240  Pyrimidine metabolism
 map00251  Glutamate metabolism

# Metabolic_Enzyme_42_Reaction:
2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

# Metabolic_Enzyme_42_Pfam_Domain_Function:
PF01979:Amidohydro_1
PF00289:CPSase_L_chain
PF02786:CPSase_L_D2
PF02787:CPSase_L_D3
PF00988:CPSase_sm_chain
PF00117:GATase
PF02142:MGS
PF00185:OTCace
PF02729:OTCace_N

# Metabolic_Enzyme_42_Signals:
Not Available

# Metabolic_Enzyme_42_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_42_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_42_EC_Link:
EC 6.3.5.5;EC 2.1.3.2;EC 3.5.2.3

# Metabolic_Enzyme_42_GenBank_ID_Protein:
1228049

# Metabolic_Enzyme_42_SwissProt_ID:
PYR1_HUMAN (P27708)

# Metabolic_Enzyme_42_swissprot_Name:
Not Available

# Metabolic_Enzyme_42_Genecard_id:
CAD

# Metabolic_Enzyme_42_Geneatlas_id:
CAD

# Metabolic_Enzyme_42_hgnc_id:
HGNC:1424

# Metabolic_Enzyme_42_PDB_ID:
Not Available

# Metabolic_Enzyme_42_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_42_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_42_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_42_Gene_Sequence:
>6678 bp
ATGGCGGCCCTAGTGTTGGAGGACGGGTCGGTCCTGCGGGGCCAGCCCTTTGGGGCCGCC
GTGTCGACTGCCGGGGAAGTGGTGTTTCAAACCGGCATGGTCGGCTACCCCGAGGCCCTC
ACTGATCCCTCCTACAAGGCACAGATCTTAGTGCTCACCTATCCTCTGATCGGCAACTAT
GGCATCCCCCCAGATGAAATGGATGAGTTCGGTCTCTGCAAGTGGTTTGAATCCTCGGGC
ATCCACGTAGCAGCACTGGTAGTGGGAGAGTGCTGTCCTACTCCCAGCCACTGGAGTGCC
ACCCGCACCCTGCATGAGTGGCTGCAGCAGCATGGCATCCCTGGCTTGCAAGGAGTAGAC
ACTCGGGAGCTGACCAAGAAGTTGCGGGAACAGGGGTCTCTGCTGGGGAAGCTGGTCCAG
AATGGAACAGAACCTTCATCCCTGCCATTCTTGGACCCCAATGCCCGCCCCCTGGTACCA
GAGGTCTCCATTAAGACTCCACGGGTATTCAATACAGGGGGTGCCCCTCGGATCCTTGCT
TTGGACTGTGGCCTCAAGTATAATCAGATCCGATGCCTCTGCCAGCGTGGGGCTGAGGTC
ACTGTGGTACCCTGGGACCATGCACTAGACAGCCAAGAGTATGAGGGTCTCTTCTTAAGT
AATGGGCCTGGTGACCCTGCCTCCTATCCCAGTGTCGTATCCACACTGAGCCGTGTTTTA
TCTGAGCCTAATCCCCGACCTGTCTTTGGGATCTGCCTGGGACACCAGCTATTGGCCTTA
GCCATTGGGGCCAAGACTTACAAGATGAGATATGGGAACCGAGGCCATAACCAGCCCTGC
TTGTTGGTGGGCTCTGGGCGCTGCTTTCTGACATCCCAGAACCATGGGTTTGCTGTGGAG
ACAGACTCACTGCCAGCAGACTGGGCTCCTCTCTTCACCAACGCCAATGATGGTTCCAAT
GAAGGCATTGTGCACAACAGCTTGCCTTTCTTCAGTGTCCAGTTTCACCCAGAGCACCAA
GCTGGCCCTTCAGATATGGAACTGCTTTTCGATATCTTTCTGGAAACTGTGAAAGAGGCC
ACAGCTGGGAACCCTGGGGGCCAGACAGTTAGAGAGCGGCTGACTGAGCGCCTCTGTCCC
CCTGGGATTCCCACTCCCGGCTCTGGACTTCCACCACCACGAAAGGTTCTGATCCTGGGC
TCAGGGGGCCTCTCCATTGGCCAAGCTGGAGAATTTGACTACTCGGGCTCTCAGGCAATT
AAGGCCCTGAAGGAGGAAAACATCCAGACGTTGCTGATCAACCCCAATATTGCCACAGTG
CAGACCTCCCAGGGGCTGGCCGACAAGGTCTATTTTCTTCCCATAACACCTCATTATGTA
ACCCAGGTGATACGTAATGAACGCCCCGATGGTGTGTTACTGACTTTTGGGGGCCAGACT
GCTCTGAACTGTGGTGTGGAGCTGACCAAGGCCGGGGTGCTGGCTCGGTATGGGGTCCGG
GTCCTGGGCACAACAGTGGAGACCATTGAGCTGACCGAGGATCGACGGGCCTTTGCTGCC
AGAATGGCAGAGATCGGAGAGCATGTGGCCCCGAGCGAGGCAGGAAATTCTCTTGAACAG
GCCCAGGCAGCCGCTGAACGGCTGGGGTACCCTGTGCTAGTGCGTGCAGCCTTTGCCGTG
GGTGGCCTGGGCTCTGGCTTTGCCTCTAACAGGGAGGAGCTCTCTGCTCTCGTGGCCCCA
GCTTTTGCCCATACCAGCCAAGTGCTAGTAGACAAGTCTCTGAAGGGATGGAAGGAGATT
GAGTACGAGGTGGTGAGAGACGCCTATGGCAACTGTGTCACGGTGTGTAACATGGAGAAC
TTGGACCCACTGGGCATCCACACTGGTGAGTCCATAGTGGTGGCCCCTAGCCAGACACTG
AATGACAGGGAGTATCAGCTCCTGAGGCAGACAGCTATCAAGGTGACCCAGCACCTGGGA
ATTGTTGGGGAGTGCAATGTGCAGTATGCCTTGAACCCTGAGTCTGAGCAGTATTACATC
ATTGAAGTGAATGCCAGGCTCTCTCGCAGCTCTGCCCTGGCCAGTAAGGCCACAGGTTAT
CCACTGGCTTATGTGGCAGCCAAGCTAGCATTGGGCATCCCTTTGCCTGAGCTCAGGAAC
TCTGTGACAGGGGGTACAGCAGCCTTTGAACCCAGCGTGGATTATTGTGTGGTGAAGATT
CCTCGATGGGACCTTAGCAAGTTCCTGCGAGTCAGCACAAAGATTGGGAGCTGCATGAAG
AGCGTTGGTGAAGTCATGGGCATTGGGCGTTCATTTGAGGAGGCCTTCCAGAAGGCCCTG
CGCATGGTGGATGAGAACTGTGTGGGCTTTGATCACACAGTGAAACCAGTCAGCGATATG
GAGTTGGAGACTCCAACAGATAAGCGGATTTTTGTGGTGGCAGCTGCTTTGTGGGCTGGT
TATTCAGTGGACCGCCTGTATGAGCTCACACGCATCGACCGCTGGTTCCTGCACCGAATG
AAGCGTATCATCGCACATGCCCAGCTGCTAGAACAACACCGTGGACAGCCTTTGCCGCCA
GACCTGCTGCAACAGGCCAAGTGTCTTGGCTTCTCAGACAAACAGATTGCCCTTGCAGTT
CTGAGCACAGAGCTGGCTGTTCGCAAGCTGCGTCAGGAACTGGGGATCTGTCCAGCAGTG
AAACAGATTGACACAGTTGCAGCTGAGTGGCCAGCCCAGACAAATTACCTATACCTAACG
TATTGGGGCACCACCCATGACCTCACCTTTCGAACACCTCATGTCCTAGTCCTTGGCTCT
GGCGTCTACCGTATTGGCTCCAGTGTTGAGTTTGACTGGTGTGCTGTAGGCTGCATCCAG
CAGCTCCGAAAGATGGGATATAAGACCATCATGGTGAACTATAACCCAGAGACAGTCAGC
ACCGACTATGACATGTGTGATCGACTCTACTTTGATGAGATCTCTTTTGAGGTGGTGATG
GACATCTATGAGCTCGAGAACCCTGAAGGTGTGATCCTATCCATGGGTGGACAGCTGCCC
AACAACATGGCCATGGCGTTGCATCGGCAGCAGTGCCGGGTGCTGGGCACCTCCCCTGAA
GCCATTGACTCGGCTGAGAACCGTTTCAAGTTTTCCCGGCTCCTTGACACCATTGGTATC
AGCCAGCCTCAGTGGAGGGAGCTCAGTGACCTCGAGTCTGCTCGCCAATTCTGCCAGACC
GTGGGGTACCCCTGTGTGGTGCGCCCCTCCTATGTGCTGAGCGGTGCTGCTATGAATGTG
GCCTACGCGGATGGAGACCTGGAGCGCTTCCTGAGCAGCGCAGCAGCCGTCTCCAAAGAG
CATCCCGTGGTCATCTCCAAGTTCATCCAGGAGGCTAAGGAGATTGACGTGGATGCCGTG
GCCTCTGATGGTGTGGTGGCAGCCATCGCCATCTCTGAGCATGTGGAGAATGCAGGTGTG
CATTCAGGTGATGCGACGCTGGTGACCCCCCCACAAGATATCACTGCCAAAACCCTGGAG
CGGATCAAAGCCATTGTGCATGCTGTGGGCCAGGAGCTACAGGTCACAGGACCCTTCAAT
CTGCAGCTCATTGCCAAGGATGACCAGCTGAAAGTTATTGAATGCAACGTACGTGTCTCT
CGCTCCTTCCCCTTCGTTTCCAAGACACTGGGTGTGGACCTAGTAGCCTTGGCCACGCGG
GTCATCATGGGGGAAGAAGTGGAACCTGTGGGGCTAATGACTGGTTCTGGAGTCGTGGGA
GTAAAGGTGCCTCAGTTCTCCTTCTCCCGCTTGGCGGGTGCTGACGTGGTGTTGGGTGTG
GAAATGACCAGTACTGGGGAGGTGGCCGGCTTTGGGGAGAGCCGCTGTGAGGCATACCTC
AAGGCCATGCTAAGCACTGGCTTTAAGATCCCCAAGAAGAATATCCTGCTGACCATTGGC
AGCTATAAGAACAAAAGCGAGCTGCTCCCAACTGTGCGGCTACTGGAGAGCCTGGGCTAC
AGCCTCTATGCCAGTCTCGGCACAGCTGACTTCTACACTGAGCATGGCGTCAAGGTAACA
GCTGTGGACTGGCACTTTGAGGAGGCTGTGGATGGTGAGTGCCCACCACAGCGGAGCATC
CTGGAGCAGCTAGCTGAGAAAAACTTTGAGCTGGTGATTAACCTGTCAATGCGTGGAGCT
GGGGGCCGGCGTCTCTCCTCCTTTGTCACCAAGGGCTACCGCACCCGACGCTTGGCCGCT
GACTTCTCCGTGCCCCTAATCATCGATATCAAGTGCACCAAACTCTTTGTGGAGGCCCTA
GGCCAGATCGGGCCAGCCCCTCCTTTGAAGGTGCATGTTGACTGTATGACCTCCCAAAAG
CTTGTGCGACTGCCGGGATTGATTGATGTCCATGTGCACCTGCGGGAACCAGGTGGGACA
CATAAGGAGGACTTTGCTTCAGGCACAGCCGCTGCCCTGGCTGGGGGTATCACCATGGTG
TGTGCCATGCCTAATACCCGGCCCCCCATCATTGACGGCCCTGCTCTGGCCCTGGCCCAG
AAGCTGGCAGAGGCTGGCGCCCGGTGCGACTTTGCGCTATTCCTTGGGGCCTCGTCTGAA
AATGCAGGAACCTTGGGCACCGTGGCCGGGTCTGCAGCCGGGCTGAAGCTTTACCTCAAT
GAGACCTTCTCTGAGCTGCGGCTGGACAGCGTGGTCCAGTGGATGGAGCATTTCGAGACA
TGGCCCTCCCACCTCCCCATTGTGGCTCACGCAGAGCAGCAAACCGTGGCTGCTGTCCTC
ATGGTGGCTCAGCTCACTCAGCGCTCAGTGCACATATGTCACGTGGCACGGAAGGAGGAG
ATCCTGCTAATTAAAGCTGCAAAGGCACGGGGCTTGCCAGTGACCTGCGAGGTGGCTCCC
CACCACCTGTTCCTAAGCCATGATGACCTGGAGCGCCTGGGGCCTGGGAAGGGGGAGGTC
CGGCCTGAGCTTGGCTCCCGCCAGGATGTGGAAGCCCTGTGGGAGGACATGGCTGTCATC
GACTGCTTTGCCTCAGACCATGCTCCCCATACCTTGGAGGAGAAGTGTGGGTCCAGGCCC
CCACCTGGGTTCCCAGGGTTAGAGACCATGCTGCCACTACTCCTGACGGCTGTAAGCGAG
GGCCGGCTCAGCCTGGACGACCTGCTGCAGCGATTGCACCACAATCCTCGGCGCATCTTT
CACCTGCCCCCGCAGGAGGACACCTATGTGGAGGTGGATCTGGAGCATGAGTGGACAATT
CCCAGCCACATGCCCTTCTCCAAGGCCCACTGGACACCTTTTGAAGGGCAGAAAGTGAAG
GGCACCGTCCGCCGTGTGGTCCTGCGAGGGGAGGTTGCCTATATCGATGGGCAGGTTCTG
GTACCCCCGGGCTATGGACAGGATGTACGGAAGTGGCCACAGGGGGCTGTTCCTCAGCTC
CCACCCTCAGCCCCTGCCACTAGTGAGATGACCACGACACCTGAAAGACCCCGCCGTGGC
ATCCCAGGGCTTCCTGATGGCCGCTTCCATCTGCCGCCCCGAATCCATCGAGCCTCCGAC
CCAGGTTTGCCAGCTGAGGAGCCAAAGGAGAAGTCCTCTCGGAAGGTAGCCGAGCCAGAG
CTGATGGGAACCCCTGATGGCACCTGCTACCCTCCACCACCAGTACCGAGACAGGCATCT
CCCCAGAACCTGGGGACCCCTGGCTTGCTGCACCCCCAGACCTCACCCCTGCTGCACTCA
TTAGTGGGCCAACATATCCTGTCCGTCCAGCAGTTCACCAAGGATCAGATGTCTCACCTG
TTCAATGTGGCACACACACTGCGTATGATGGTGCAGAAGGAGCGGAGCCTCGACATCCTG
AAGGGGAAGGTCATGGCCTCCATGTTCTATGAAGTGAGCACACGGACCAGCAGCTCCTTT
GCAGCAGCCATGGCCCGGCTGGGAGGTGCTGTGCTCAGCTTCTCGGAAGCCACATCGTCC
GTCCAGAAGGGCGAATCCCTGGCTGACTCCGTGCAGACCATGAGCTGCTATGCCGACGTC
GTCGTGCTCCGGCACCCCCAGCCTGGAGCAGTGGAGCTGGCCGCCAAGCACTGCCGGAGG
CCAGTGATCAATGCTGGGGATGGGGTCGGAGAGCACCCCACCCAGGCCCTGCTGGACATC
TTCACCATCCGTGAGGAGCTGGGAACTGTCAATGGCATGACGATCACGATGGTGGGTGAC
CTGAAGCACGGACGCACAGTACATTCCCTGGCCTGCCTGCTCACCCAGTATCGTGTCAGC
CTGCGCTACGTGGCACCTCCCAGCCTGCGCATGCCACCCACTGTGCGGGCCTTCGTGGCC
TCCCGCGGCACCAAGCAGGAGGAATTCGAGAGCATTGAGGAGGCGCTGCCTGACACTGAT
GTGCTCTACATGACTCGAATCCAGAAGGAACGATTTGGCTCTACCCAGGAGTACGAAGCT
TGCTTTGGTCAGTTCATCCTCACTCCCCACATCATGACCCGGGCCAAGAAGAAGATGGTG
GTGATGCACCCGATGCCCCGTGTCAACGAGATAAGCGTGGAAGTGGACTCGGATCCCCGC
GCAGCCTACTTCCGCCAGGCTGAGAACGGCATGTACATCCGCATGGCTCTGTTAGCCACC
GTGCTGGGCCGTTTCTAG

# Metabolic_Enzyme_42_GenBank_ID_Gene:
D78586

# Metabolic_Enzyme_42_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_42_Locus:
2p22-p21

# Metabolic_Enzyme_42_SNPs:
rs10193746; rs2304684; rs1141313; rs3739092; rs2078616; rs2014252; rs3769143; rs7593448; rs724310; rs13399758; rs6717980; rs724311; rs4665958; rs1275537; rs9679426; rs13395251; rs2043921; rs6749393; rs17005956; rs13424394; rs11685326; rs1275538; rs9309604; rs6756856; rs7589553; rs17005959; rs4665959; rs1561536; rs17005965; rs13384642; rs7557294; rs13394037; rs35133828; rs7573037; rs6747264; rs1141311; rs11559294; rs35391069; rs2289363; rs1056891; rs1141312; rs17855321; rs1275536; rs34716401; rs34760549; rs2289362; rs11682203; rs3739094; rs34370500; rs41288817; rs10172199; rs34961252; rs41288819; rs41288815; rs34977313; rs3739093; rs35508676; rs4603717; rs35275954; rs34729450; rs12612959; rs34346820; rs5830040; rs35324417; rs10636656; rs41288813; rs3214689; rs10172758; rs13430035; rs17005962; rs11361649; rs35233183; rs35736485; rs1044325; rs11126918; rs11126929; rs11126931; rs11608; rs11674947; rs11682913; rs11693660; rs11885879; rs11897090; rs11936; rs1275528; rs1275529; rs1275530; rs1275531; rs1275532; rs1275533; rs12986755; rs1561535; rs2083363; rs2580758; rs2580759; rs2735864; rs4617; rs4665960; rs6547496; rs7437; rs7600932; rs9653564; rs996650

# Metabolic_Enzyme_42_General_References:
8619816; 1979741

# Metabolic_Enzyme_42_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
6003

# Macromolecular_Interacting_Partner_1_Name:
Gamma-glutamyltransferase-like protein 2

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
GGT2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Gammaglutamyltransferaselike protein 2
MTSEFFAAQLRSQISDHTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYG
ILFNNEWTTSALPAFTNEFGAPPSPANFIQPGKQPLLSMCLTIMVGQDGQVRMVVGAAGG
TQITTDTALAIIYNLWFGYDVKRAVEEPRLHNKLLPNVTTVERNIDQAVTAALETRHHHT
QIASTFIAVVQAIVRTAGGWAAALDSRKGGEPAGY

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
215

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
23152

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.85

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring amino-acyl groups
Function:  gamma-glutamyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01019:G_glu_transpept

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
GGTL2_HUMAN (P36268)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
GGT2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
GGT2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:4251

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AP000550

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_1_Locus:
22q11.21|22q11.1

# Macromolecular_Interacting_Partner_1_SNPs:
rs3984302; rs1055042; rs8139086; rs8140378; rs5747777; rs12157499; rs243423; rs16984529; rs4619710; rs531659; rs458129; rs3984335; rs3984362; rs615918; rs585882; rs3095824; rs4627683; rs3984348; rs2416648; rs3984350; rs524221; rs3984344; rs675932; rs3984359; rs429047; rs419876; rs3984347; rs425672; rs5747781; rs243430; rs712972; rs3893047; rs365982; rs243428; rs243429; rs370606; rs243431; rs2080690; rs5993280; rs3984324; rs243424; rs5742550; rs4619711; rs4532045; rs5992267; rs243422; rs3984309; rs3984322; rs645912; rs5993253; rs12163291; rs9605723; rs5747772; rs5992265; rs3984304; rs5747745; rs5993279; rs7289002; rs5993283; rs3984317; rs2330839; rs28454543; rs3984310; rs645874; rs5993281; rs12163068; rs28484915; rs5747773; rs3984323; rs3984308; rs3984320; rs4482586; rs5742291; rs5746592; rs3984307; rs28457127; rs5992266; rs28570688; rs445155; rs3984318; rs5992264; rs3984383; rs3962704; rs1682970; rs5992258; rs5747768; rs634241; rs5993260; rs12172311; rs5992261; rs3865661; rs3984340; rs11703106; rs3984377; rs415866; rs3984396; rs592227; rs592678; rs3984356; rs28432349; rs4453774; rs3984341; rs5747771; rs3962702; rs5993262; rs5993274; rs28545002; rs376710; rs3984328; rs5746589; rs9605714; rs3984369; rs3984381; rs12160828; rs3984332; rs5747751; rs12172441; rs3984343; rs3984354; rs3984365; rs527127; rs5993268; rs3984331; rs416172; rs5992255; rs3962683; rs3984326; rs5747761; rs618606; rs2416647; rs2544149; rs491974; rs28373739; rs9617727; rs3984370; rs3984367; rs3984373; rs407014; rs5747770; rs3984351; rs9605713; rs3095770; rs3984333; rs3865660; rs3962699; rs3852971; rs5993257; rs12172257; rs9605715; rs521558; rs3984342; rs3984349; rs431943; rs3984368; rs3894040; rs3984375; rs3095823; rs4532044; rs416669; rs5993273; rs5992262; rs678219; rs388369; rs391221; rs5742290; rs3984361; rs5747747; rs3984363; rs5747750; rs3894042; rs12160575; rs5993263; rs28676434; rs604301; rs3984338; rs3896619; rs5747759; rs3962701; rs5742579; rs5992260; rs5747769; rs5747760; rs439131; rs3984329; rs9604865; rs3962700; rs563090; rs3894044; rs3984345; rs5993261; rs3962682; rs3984382; rs3984371; rs9605710; rs3984364; rs3984352; rs3984339; rs604353; rs3984327; rs5992257; rs2544148; rs5747762; rs5747754; rs407275; rs5993278; rs5993258; rs391231; rs492871; rs3984372; rs5747764; rs5747755; rs3984366; rs12172258; rs5993267; rs5747749; rs3875899; rs5992263; rs3962705; rs5993259; rs7510731; rs28661417; rs413929; rs5747779; rs364896; rs444912; rs4621252; rs4819722; rs9618341; rs847019; rs3984403; rs363963; rs5747780; rs370956; rs7510856; rs12163131; rs243427

# Macromolecular_Interacting_Partner_1_General_References:
10591208; 2573352

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8471

# Macromolecular_Interacting_Partner_2_Name:
Cystine/glutamate transporter

# Macromolecular_Interacting_Partner_2_Synonyms:
Amino acid transport system xc-; xCT; Calcium channel blocker resistance protein CCBR1

# Macromolecular_Interacting_Partner_2_Gene_Name:
SLC7A11

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Cystine/glutamate transporter
MVRKPVVSTISKGGYLQGNVNGRLPSLGNKEPPGQEKVQLKRKVTLLRGVSIIIGTIIGA
GIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYILEVFGP
LPAFVRVWVELLIIRPAATAVISLAFGRYILEPFFIQCEIPELAIKLITAVGITVVMVLN
SMSVSWSARIQIFLTFCKLTAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFY
YGMYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEELLLS
NAVAVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHV
RKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYKCPDMHRP
FKVPLFIPALFSFTCLFMVALSLYSDPFSTGIGFVITLTGVPAYYLFIIWDKKPRWFRIM
SEKITRTLQIILEVVPEEDKL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
501

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
55424

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
9.51

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  amino acid permease activity
Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
 Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_2_Specific_Function:
Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_2_Signals:
Not Available

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
44-64
75-95
114-134
159-179
190-210
235-255
266-286
318-338
365-385
388-408
423-443
450-470

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
5668545

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
XCT_HUMAN (Q9UPY5)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
SLC7A11

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
SLC7A11

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:11059

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1506 bp
ATGGTCAGAAAGCCTGTTGTGTCCACCATCTCCAAAGGAGGTTACCTGCAGGGAAATGTT
AACGGGAGGCTGCCTTCCCTGGGCAACAAGGAGCCACCTGGGCAGGAGAAAGTGCAGCTG
AAGAGGAAAGTCACTTTACTGAGGGGAGTCTCCATTATCATTGGCACCATCATTGGAGCA
GGAATCTTCATCTCTCCTAAGGGCGTGCTCCAGAACACGGGCAGCGTGGGCATGTCTCTG
ACCATCTGGACGGTGTGTGGGGTCCTGTCACTATTTGGAGCTTTGTCTTATGCTGAATTG
GGAACAACTATAAAGAAATCTGGAGGTCATTACACATATATTTTGGAAGTCTTTGGTCCA
TTACCAGCTTTTGTACGAGTCTGGGTGGAACTCCTCATAATACGCCCTGCAGCTACTGCT
GTGATATCCCTGGCATTTGGACGCTACATTCTGGAACCATTTTTTATTCAATGTGAAATC
CCTGAACTTGCGATCAAGCTCATTACAGCTGTGGGCATAACTGTAGTGATGGTCCTAAAT
AGCATGAGTGTCAGCTGGAGCGCCCGGATCCAGATTTTCTTAACCTTTTGCAAGCTCACA
GCAATTCTGATAATTATAGTCCCTGGAGTTATGCAGCTAATTAAAGGTCAAACGCAGAAC
TTTAAAGACGCGTTTTCAGGAAGAGATTCAAGTATTACGCGGTTGCCACTGGCTTTTTAT
TATGGAATGTATGCATATGCTGGCTGGTTTTACCTCAACTTTGTTACTGAAGAAGTAGAA
AACCCTGAAAAAACCATTCCCCTTGCAATATGTATATCCATGGCCATTGTCACCATTGGC
TATGTGCTGACAAATGTGGCCTACTTTACGACCATTAATGCTGAGGAGCTGCTGCTTTCA
AATGCAGTGGCAGTGACCTTTTCTGAGCGGCTACTGGGAAATTTCTCATTAGCAGTTCCG
ATCTTTGTTGCCCTCTCCTGCTTTGGCTCCATGAACGGTGGTGTGTTTGCTGTCTCCAGG
TTATTCTATGTTGCGTCTCGAGAGGGTCACCTTCCAGAAATCCTCTCCATGATTCATGTC
CGCAAGCACACTCCTCTACCAGCTGTTATTGTTTTGCACCCTTTGACAATGATAATGCTC
TTCTCTGGAGACCTCGACAGTCTTTTGAATTTCCTCAGTTTTGCCAGGTGGCTTTTTATT
GGGCTGGCAGTTGCTGGGCTGATTTATCTTCGATACAAATGCCCAGATATGCATCGTCCT
TTCAAGGTGCCACTGTTCATCCCAGCTTTGTTTTCCTTCACATGCCTCTTCATGGTTGCC
CTTTCCCTCTATTCGGACCCATTTAGTACAGGGATTGGCTTCGTCATCACTCTGACTGGA
GTCCCTGCGTATTATCTCTTTATTATATGGGACAAGAAACCCAGGTGGTTTAGAATAATG
TCAGAGAAAATAACCAGAACATTACAAATAATACTGGAAGTTGTACCAGAAGAAGATAAG
TTATGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AB026891

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_2_Locus:
4q28-q32

# Macromolecular_Interacting_Partner_2_SNPs:
rs4479754; rs6838248; rs35701885; rs7674870; rs13144383; rs4560461; rs1018278; rs4580699; rs7695989; rs4241940; rs4241939; rs6852562; rs4863772; rs6537201; rs4241938; rs6848356; rs7682497; rs6854381; rs4863771; rs4346698; rs6537262; rs6537245; rs6537243; rs4616810; rs4461565; rs6832143; rs6537244; rs6851845; rs4604102; rs4450980; rs4330397; rs4635863; rs6854495; rs4429772; rs4602539; rs4501269; rs6811062; rs4295318; rs4863768; rs7667390; rs7663187; rs11723658; rs5028340; rs17050206; rs11727731; rs13137929; rs6823642; rs7666936; rs7685529; rs4863767; rs6832329; rs11728841; rs11100834; rs12506333; rs11726394; rs4504306; rs1513770; rs11944083; rs2203292; rs3935420; rs10016559; rs10011428; rs11731957; rs4432801; rs1018279; rs11941210; rs5010683; rs11734488; rs6823797; rs4131888; rs5028339; rs12507560; rs5028338; rs35509920; rs7670361; rs4458505; rs6826686; rs6842328; rs6831157; rs4597880; rs10519451; rs11726904; rs13123358; rs11100856; rs13141329; rs4277825; rs13434884; rs12648268; rs11728401; rs6849136; rs11100852; rs11726938; rs4863770; rs11722075; rs11723941; rs7691115; rs7669379; rs12644169; rs12648155; rs4495092; rs4285139; rs2037027; rs11100861; rs7674749; rs4863541; rs7687893; rs4863769; rs6856980; rs10007843; rs10023744; rs4605709; rs6836568; rs11100854; rs12501178; rs10013651; rs907846; rs6842877; rs4346696; rs7663737; rs7688870; rs11942121; rs4353954; rs4343770; rs28364686; rs7442098; rs34757167; rs35186416; rs7436071; rs28475437; rs35902409; rs34210801; rs35238413; rs41280525; rs28535605; rs35108180; rs35668334; rs34738111; rs35743443; rs35233426; rs35863021; rs35848384; rs35603182; rs11558459; rs13120371; rs1828731; rs11721615; rs13102641; rs34634857; rs4863776; rs33981028; rs34133691; rs35538364; rs36084343; rs35871663; rs34001412; rs34499486; rs9991050; rs35902152; rs34428505; rs34564510; rs11429332; rs1398923; rs11285067; rs2314121; rs10659044; rs35797835; rs2037026; rs33971395; rs5862368; rs35822309; rs35216782; rs11363996; rs1828730; rs34693752; rs35563320; rs11724121; rs4863774; rs35551178; rs13148828; rs35729298; rs6843843; rs7440857; rs34121751; rs35422271; rs36060958; rs33961040; rs34647587; rs34057129; rs4863777; rs33945630; rs5862371; rs6842998; rs7696571; rs35774256; rs28670077; rs35824332; rs34732195; rs4453980; rs1828732; rs10716464; rs34733668; rs34472915; rs7677872; rs34688199; rs10671098; rs35936061; rs35820354; rs33978369; rs6830952; rs35099716; rs35289109; rs35338542; rs11382936; rs34896335; rs35422742; rs1913363; rs34190069; rs41280523; rs6842856; rs10001990; rs7699450; rs34270387; rs6819425; rs13140611; rs36089984; rs35860915; rs13123740; rs13113911; rs10025342; rs34405738; rs4568283; rs7673617; rs34188819; rs4863775; rs35582919; rs28524564; rs5862370; rs34078647; rs35396062; rs5022856; rs34464195; rs35446857; rs13138630; rs34322730; rs35726185; rs35359984; rs5862372; rs4561972; rs41280521; rs35135719; rs36216785; rs11372828; rs34625368; rs4863542; rs10691284; rs34466652; rs7663676; rs35571326; rs34747400; rs35914546; rs7340842; rs7697170; rs5862369; rs36060692; rs28655080; rs36203833; rs10025829; rs34108100; rs34009346; rs5010682; rs4323159; rs35397453; rs35899188; rs34874320; rs1513769; rs34893241; rs35372640; rs34728132; rs35014012; rs35955922; rs33960589; rs34908809; rs35625609; rs28364685; rs11726852; rs13113286; rs34003769; rs35372556; rs4863765; rs4863766; rs6821659; rs6841268; rs7660742; rs7682546

# Macromolecular_Interacting_Partner_2_General_References:
11213471

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8627

# Macromolecular_Interacting_Partner_3_Name:
4F2 cell-surface antigen heavy chain

# Macromolecular_Interacting_Partner_3_Synonyms:
4F2hc; Lymphocyte activation antigen 4F2 large subunit; 4F2 heavy chain antigen; CD98 antigen

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC3A2

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>4F2 cellsurface antigen heavy chain
MSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKF
TGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHT
GALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQID
PNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAG
VDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLT
SSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLP
GTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLS
LFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQAS
DLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYAA

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
529

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
57945

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
4.99

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  amylase activity
Function:  alpha-amylase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_3_Specific_Function:
Involved in sodium-independent, high-affinity transport of large neutral amino acids. Required for normal and neoplastic cell growth

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00128:Alpha-amylase

# Macromolecular_Interacting_Partner_3_Signals:
1-98

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
82-104

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
182865

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
4F2_HUMAN (P08195)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC3A2

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC3A2

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:11026

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1590 bp
ATGAGCCAGGACACCGAGGTGGATATGAAGGAGGTGGAGCTGAATGAGTTAGAGCCCGAG
AAGCAGCCGATGAACGCGGCGTCTGGGGCGGCCATGTCCCTGGCGGGAGCCGAGAAGAAT
GGTCTGGTGAAGATCAAGGTGGCGGAAGACGAGGCGGAGGCGGCAGCCGCGGCTAAGTTC
ACGGGCCTGTCCAAGGAGGAGCTGCTGAAGGTGGCAGGCAGCCCCGGCTGGGTACGCACC
CGCTGGGCACTGCTGCTGCTCTTCTGGCTCGGCTGGCTCGGCATGCTTGCTGGTGCCGTG
GTCATAATCGTGCGAGCGCCGCGTTGTCGCGAGCTACCGGCGCAGAAGTGGTGGCACACG
GGCGCCCTCTACCGCATCGGCGACCTTCAGGCCTTCCAGGGCCACGGCGCGGGCAACCTG
GCGGGTCTGAAGGGGCGTCTCGATTACCTGAGCTCTCTGAAGGTGAAGGGCCTTGTGCTG
GGTCCAATTCACAAGAACCAGAAGGATGATGTCGCTCAGACTGACTTGCTGCAGATCGAC
CCCAATTTTGGCTCCAAGGAAGATTTTGACAGTCTCTTGCAATCGGCTAAAAAAAAGAGC
ATCCGTGTCATTCTGGACCTTACTCCCAACTACCGGGGTGAGAACTCGTGGTTCTCCACT
CAGGTTGACACTGTGGCCACCAAGGTGAAGGATGCTCTGGAGTTTTGGCTGCAAGCTGGC
GTGGATGGGTTCCAGGTTCGGGACATAGAGAATCTGAAGGATGCATCCTCATTCTTGGCT
GAGTGGCAAAATATCACCAAGGGCTTCAGTGAAGACAGGCTCTTGATTGCGGGGACTAAC
TCCTCCGACCTTCAGCAGATCCTGAGCCTACTCGAATCCAACAAAGACTTGCTGTTGACT
AGCTCATACCTGTCTGATTCTGGTTCTACTGGGGAGCATACAAAATCCCTAGTCACACAG
TATTTGAATGCCACTGGCAATCGCTGGTGCAGCTGGAGTTTGTCTCAGGCAAGGCTCCTG
ACTTCCTTCTTGCCGGCTCAACTTCTCCGACTCTACCAGCTGATGCTCTTCACCCTGCCA
GGGACCCCTGTTTTCAGCTACGGGGATGAGATTGGCCTGGATGCAGCTGCCCTTCCTGGA
CAGCCTATGGAGGCTCCAGTCATGCTGTGGGATGAGTCCAGCTTCCCTGACATCCCAGGG
GCTGTAAGTGCCAACATGACTGTGAAGGGCCAGAGTGAAGACCCTGGCTCCCTCCTTTCC
TTGTTCCGGCGGCTGAGTGACCAGCGGAGTAAGGAGCGCTCCCTACTGCATGGGGACTTC
CACGCGTTCTCCGCTGGGCCTGGACTCTTCTCCTATATCCGCCACTGGGACCAGAATGAG
CGTTTTCTGGTAGTGCTTAACTTTGGGGATGTGGGCCTCTCGGCTGGACTGCAGGCCTCC
GACCTGCCTGCCAGCGCCAGCCTCCCAGCCAAGGCTGACCTCCTGCTCAGCACCCAGCCA
GGCCGTGAGGAGGGCTCCCCTCTTGAGCTGGAACGCCTGAAACTGGAGCCTCACGAAGGG
CTGCTGCTCCGCTTCCCCTACGCGGCCTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
J02939

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11q13

# Macromolecular_Interacting_Partner_3_SNPs:
rs4726; rs6932; rs489381; rs10897300; rs10897301; rs10792362; rs3809075; rs12221878; rs481235; rs12577251; rs4567465; rs12794763; rs7104190; rs507101; rs7106901; rs12098955; rs561385; rs519473; rs12804553; rs12274689; rs7935096; rs2070870; rs2920155; rs2282477; rs1140538; rs7944051; rs3015957; rs11548759; rs1051342; rs11548756; rs1051289; rs1051290; rs1802910; rs1051237; rs1802911; rs11548760; rs1051285; rs12272749; rs35228448; rs540791; rs549706; rs11231260; rs543622; rs541444; rs34047097; rs35246991; rs1815840; rs3840765; rs11231257; rs544453; rs35881347; rs35320203; rs2957168; rs7130029; rs519425; rs541388; rs34176851; rs535854; rs35091612; rs7106895; rs2096559; rs473815; rs11318751; rs5792273; rs12797676; rs499294; rs34225665; rs3809074; rs2957166; rs7115838; rs12803557; rs521939; rs1938675; rs563394; rs1300138; rs12225962; rs2105515; rs36034735; rs486306; rs12788771; rs1212628; rs1286159; rs5792274; rs12794229; rs7117639; rs495776; rs11231259; rs12366036; rs509327; rs35657900; rs11231261; rs496788; rs35988334; rs12788770; rs34335071; rs1298673; rs766316; rs34722625; rs560603; rs11824602; rs565303; rs34494671; rs35455481; rs7101685; rs1286160; rs510307; rs12270563; rs11231254; rs11231262; rs11318752; rs549635; rs12270604; rs2957167; rs11317361; rs7126772; rs34436839; rs11341257; rs577134; rs11558674; rs1059292; rs11231249; rs11231250; rs12270342; rs12295052; rs1785940; rs2071036; rs2269353; rs2507820; rs2509678; rs2510083; rs3737388; rs3737389; rs4034; rs480730; rs493851; rs498751; rs524891; rs547248; rs560006

# Macromolecular_Interacting_Partner_3_General_References:
3476959; 3036867; 3480538; 3265470; 12754519; 11840567; 12270127

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8631

# Macromolecular_Interacting_Partner_4_Name:
Excitatory amino acid transporter 3

# Macromolecular_Interacting_Partner_4_Synonyms:
Solute carrier family 1 member 1; Sodium-dependent glutamate/aspartate transporter 3; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC1A1

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Excitatory amino acid transporter 3
MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILM
RMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGV
TQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMT
EESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFF
NALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVI
LPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLP
VGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMV
IVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVN
IVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
524

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
57101

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
5.36

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
 Function:  transporter activity
Function:  organic acid transporter activity
Function:  carboxylic acid transporter activity
Function:  dicarboxylic acid transporter activity
Function:  sodium:dicarboxylate symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  organic acid transport
Process:  carboxylic acid transport
Process:  dicarboxylic acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_4_Specific_Function:
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00375:SDF

# Macromolecular_Interacting_Partner_4_Signals:
1-31

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
19-38
62-82
94-114
210-229
254-273
290-309
316-335
362-381
392-411
420-439

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
507898

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
EAA3_HUMAN (P43005)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC1A1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC1A1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:10939

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1575 bp
ATGGGGAAACCGGCGAGGAAAGGATGCGAGTGGAAGCGCTTCCTGAAGAATAACTGGGTG
TTGCTGTCCACCGTGGCCGCGGTGGTGCTAGGCATTACCACAGGAGTCTTGGTTCGAGAA
CACAGCAACCTCTCAACTCTAGAGAAATTCTACTTTGCTTTTCCTGGAGAAATTCTAATG
CGGATGCTGAAACTCATCATTTTGCCATTAATTATATCCAGCATGATTACAGGTGTTGCT
GCACTGGATTCCAACGTATCCGGAAAAATTGGTCTGCGCGTCGTCGTGTATTATTTCTGT
ACCACTCTCATTGCTGTTATTCTAGGTATTGTGCTGGTGGTGAGCATCAAGCCTGGTGTC
ACCCAGAAAGTGGGTGAAATTGCGAGGACAGGCAGCACCCCTGAAGTCAGTACGGTGGAT
GCCATGTTAGATCTCATCAGGAATATGTTCCCTGAGAATCTTGTCCAGGCCTGTTTTCAG
CAGTACAAAACTAAGCGTGAAGAAGTGAAGCCTCCCAGCGATCCAGAGATGAACATGACA
GAAGAGTCCTTCACAGCTGTCATGACAACTGCAATTTCCAAGAACAAAACAAAGGAATAC
AAAATTGTTGGCATGTATTCAGATGGCATAAACGTCCTGGGCTTGATTGTCTTTTGCCTT
GTCTTTGGACTTGTCATTGGAAAAATGGGAGAAAAGGGACAAATTCTGGTGGATTTCTTC
AATGCTTTGAGTGATGCAACCATGAAAATCGTTCAGATCATCATGTGTTATATGCCACTA
GGTATTTTGTTCCTGATTGCTGGGAAGATCATAGAAGTTGAAGACTGGGAAATATTCGCA
AAGCTGGGCCTTTACATGGCCACAGTCCTGACTGGGCTTGCAATCCACTCCATTGTAATT
CTCCCGCTGATATATTTCATAGTCGTACGAAAGAACCCTTTCCGATTTGCCATGGGAATG
GCCCAGGCTCTCCTGACAGCTCTCATGATCTCTTCCAGTTCAGCAACACTGCCTGTCACC
TTCCGCTGTGCTGAAGAAAATAACCAGGTGGACAAGAGGATCACTCGATTCGTGTTACCC
GTTGGTGCAACAATCAACATGGATGGGACTGCGCTCTATGAAGCAGTGGCAGCGGTGTTT
ATTGCACAGTTGAATGACCTGGACTTGGGCATTGGGCAGATCATCACCATCAGTATCACG
GCCACATCTGCCAGCATCGGAGCTGCTGGCGTGCCCCAGGCTGGCCTGGTGACCATGGTG
ATTGTGCTGAGTGCCGTGGGCCTGCCCGCCGAGGATGTCACCCTGATCATTGCTGTCGAC
TGGCTCCTGGACCGGTTCAGGACCATGGTCAACGTCCTTGGTGATGCTTTTGGGACGGGC
ATTGTGGAAAAGCTCTCCAAGAAGGAGCTGGAGCAGATGGATGTTTCATCTGAAGTCAAC
ATTGTGAATCCTTTTGCCTTGGAATCCACAATCCTTGACAACGAAGACTCAGACACCAAG
AAGTCTTATGTCAATGGAGGCTTTGCAGTAGACAAGTCTGACACCATCTCATTCACCCAG
ACCTCACAGTTCTAG

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
U08989

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_4_Locus:
9p24

# Macromolecular_Interacting_Partner_4_SNPs:
rs16921449; rs2026828; rs1888279; rs2039291; rs1980943; rs2039216; rs2094806; rs10758631; rs7046262; rs7029281; rs928209; rs10758628; rs7848533; rs10758624; rs10739065; rs7025968; rs7851538; rs2039290; rs4742003; rs10739064; rs7023050; rs2026829; rs10118909; rs7033181; rs6476876; rs7021569; rs10814995; rs10758629; rs9918970; rs7044130; rs10814998; rs6476877; rs6476875; rs7862687; rs10815015; rs10491732; rs10814997; rs7022369; rs10115600; rs7032326; rs4742005; rs10815004; rs6476871; rs10974588; rs17755777; rs4742004; rs10733515; rs7860087; rs10117861; rs10974615; rs7030825; rs7037863; rs6476873; rs10974592; rs7045401; rs2150195; rs10491731; rs6476874; rs10815002; rs10119456; rs17812372; rs913991; rs951458; rs7021409; rs10116014; rs7041093; rs972519; rs10758632; rs10815013; rs10815016; rs16921385; rs7864309; rs10814991; rs10739062; rs10758623; rs7867651; rs7849913; rs6476872; rs17812250; rs7864081; rs10974587; rs10974616; rs7024664; rs17812268; rs12342908; rs10815019; rs7038739; rs12004546; rs12003904; rs16921457; rs12004065; rs10815018; rs10974610; rs7860715; rs12338459; rs12002726; rs16921367; rs17755625; rs10974594; rs12380549; rs10739061; rs10815011; rs10974577; rs10974581; rs10974600; rs7852072; rs10814994; rs10118904; rs10974590; rs10815010; rs10815017; rs10974597; rs10119479; rs7864220; rs1330688; rs17811619; rs17811535; rs7857946; rs10974601; rs10815009; rs10974582; rs17755904; rs17811505; rs13289148; rs10814993; rs10815014; rs17755472; rs10815003; rs17812396; rs10974612; rs7030226; rs7848305; rs9774826; rs10974586; rs10974591; rs7873961; rs10974614; rs9777096; rs10815006; rs17756150; rs7468917; rs7029501; rs10758626; rs4641119; rs10974611; rs12003869; rs17755789; rs10815008; rs10814992; rs10739063; rs12351945; rs10974613; rs10974606; rs10815005; rs12341219; rs7036458; rs12351328; rs10974580; rs17756556; rs7046808; rs10120326; rs7027993; rs17812232; rs4008488; rs10974584; rs10974607; rs1330686; rs10815012; rs17755168; rs10815007; rs7850152; rs7031998; rs1360329; rs7043415; rs1537035; rs2017074; rs10814990; rs4740789; rs1807276; rs2381122; rs884931; rs12000219; rs7026816; rs35883411; rs10974605; rs35964381; rs35461755; rs35169624; rs34455753; rs34089295; rs35074500; rs34997218; rs35752798; rs12005504; rs34994137; rs36057961; rs34866467; rs1888280; rs34014603; rs34939038; rs34489534; rs35698960; rs35190872; rs12006310; rs12001534; rs34976367; rs36164361; rs7019270; rs35875422; rs5896082; rs12352574; rs10974585; rs35158764; rs34256260; rs35815316; rs3038189; rs10974599; rs34600342; rs13289187; rs10974604; rs10974593; rs7866742; rs7033497; rs10974609; rs11535414; rs34665485; rs34199207; rs7852263; rs35714906; rs10974598; rs35337308; rs7470929; rs10974589; rs34928579; rs2890588; rs36097515; rs34195319; rs12005500; rs5896081; rs10114781; rs12350574; rs4517184; rs35672344; rs7038104; rs1330689; rs34899758; rs36157852; rs34258078; rs34271544; rs12353010; rs36051748; rs34630480; rs10974595; rs10974608; rs35001777; rs10974579; rs34147711; rs10758630; rs5896079; rs28852219; rs10116863; rs35897785; rs11521467; rs7048761; rs10974617; rs11521469; rs34428793; rs5896080; rs4373569; rs6150901; rs12341097; rs10974596; rs7856981; rs34982876; rs34881451; rs34631013; rs12351985; rs34559140; rs34337455; rs34738080; rs10974575; rs11521468; rs7029194; rs10974578; rs34610062; rs10974574; rs5896078; rs10117931; rs10121074; rs10491733; rs10491734; rs10491735; rs1051818; rs1051825; rs1051830; rs1051831; rs1051835; rs10739066; rs1078539; rs10814987; rs10814988; rs10815020; rs10815021; rs10974568; rs10974573; rs10974619; rs10974620; rs10974622; rs10974623; rs10974624; rs10974625; rs10974628; rs10974629; rs10974632; rs10974634; rs10974635; rs10974636; rs11788512; rs11791930; rs11792309; rs11795172; rs11999543; rs12001262; rs12002441; rs12004839; rs12005132; rs12336560; rs12337810; rs12353525; rs12378107; rs12379402; rs12551465; rs12553697; rs12682807; rs13285395; rs1471786; rs159914; rs159916; rs16921510; rs17756747; rs17756784; rs17814324; rs184204; rs188537; rs190978; rs2072657; rs2150192; rs2183472; rs2228622; rs301429; rs301430; rs301431; rs301432; rs301433; rs301434; rs301435; rs301436; rs301437; rs301439; rs301440; rs301441; rs301443; rs301444; rs301445; rs301446; rs301979; rs3056; rs3087879; rs34342853; rs34345944; rs34623313; rs35045656; rs3780411; rs3780412; rs3780413; rs3780414; rs3780415; rs4376537; rs4376542; rs4740788; rs4740790; rs4742006; rs4742007; rs4742008; rs4742009; rs4742010; rs4742011; rs6476878; rs6476879; rs7022772; rs7042333; rs7045876; rs7856675; rs7858215; rs7858819; rs7858877; rs7864496; rs7868565; rs7871243; rs7871691; rs7872075; rs9407286; rs9886720; rs9886723; rs9886808; rs9886847

# Macromolecular_Interacting_Partner_4_General_References:
7859077; 7914198; 7521911

# Macromolecular_Interacting_Partner_4_References:
Not Available

# Macromolecular_Interacting_Partner_5_ID:
8642

# Macromolecular_Interacting_Partner_5_Name:
Mitochondrial glutamate carrier 2

# Macromolecular_Interacting_Partner_5_Synonyms:
GC-2; Glutamate/H(+symporter 2; Solute carrier family 25 member 18

# Macromolecular_Interacting_Partner_5_Gene_Name:
SLC25A18

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Mitochondrial glutamate carrier 2
MTHQDLSITAKLINGGVAGLVGVTCVFPIDLAKTRLQNQHGKAMYKGMIDCLMKTARAEG
FFGMYRGAAVNLTLVTPEKAIKLAANDFFRRLLMEDGMQRNLKMEMLAGCGAGMCQVVVT
CPMEMLKIQLQDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPSATLIAWELLRTQGLA
GLYRGLGATLLRDIPFSIIYFPLFANLNNLGFNELAGKASFAHSFVSGCVAGSIAAVAVT
PLDVLKTRIQTLKKGLGEDMYSGITDCARKLWIQEGPSAFMKGAGCRALVIAPLFGIAQG
VYFIGIGERILKCFD

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
315

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
33849

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
9.62

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
 Function:  binding
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  organelle membrane
Component:  organelle inner membrane
Component:  mitochondrial inner membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+)

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00153:Mito_carr

# Macromolecular_Interacting_Partner_5_Signals:
Not Available

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
12-32
106-126
185-205
225-245
288-308

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
21322707

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
GHC2_HUMAN (Q9H1K4)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
SLC25A18

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
SLC25A18

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:10988

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>948 bp
ATGACCCACCAGGATCTGAGCATCACAGCCAAACTCATCAATGGAGGTGTAGCAGGGCTC
GTGGGGGTGACCTGCGTGTTCCCCATCGACTTGGCCAAGACTCGCCTGCAGAACCAGCAT
GGGAAAGCCATGTACAAAGGAATGATCGACTGCCTGATGAAGACGGCTCGGGCGGAGGGC
TTCTTCGGCATGTACCGAGGGGCTGCAGTGAACCTCACTCTGGTCACTCCAGAGAAGGCC
ATCAAGCTGGCGGCCAACGACTTTTTCCGGCGGCTGCTCATGGAAGATGGGATGCAGCGG
AACCTGAAGATGGAGATGCTTGCCGGGTGTGGGGCTGGGATGTGCCAGGTCGTGGTGACC
TGTCCCATGGAAATGCTCAAGATTCAGCTGCAGGATGCTGGACGCCTGGCCGTCCATCAT
CAGGGCTCGGCCTCAGCACCCTCCACCTCCAGGTCCTACACAACTGGTTCGGCTTCCACC
CACAGGCGCCCCTCTGCCACCCTCATTGCCTGGGAGCTGCTCCGCACTCAGGGCCTGGCT
GGGCTCTACAGGGGCCTGGGTGCCACTCTCCTCAGAGACATTCCTTTCTCCATCATCTAC
TTCCCACTGTTTGCCAACCTTAACAACCTGGGGTTCAACGAGCTCGCCGGTAAGGCGTCC
TTTGCACATTCCTTCGTGTCAGGCTGTGTGGCAGGTTCCATAGCTGCGGTCGCAGTGACG
CCTCTAGATGTTCTGAAAACTCGAATCCAAACCCTCAAGAAAGGCCTGGGCGAGGACATG
TACAGTGGGATCACCGACTGTGCCAGGAAACTCTGGATTCAGGAGGGACCATCTGCCTTC
ATGAAAGGCGCTGGCTGCCGGGCACTGGTCATAGCACCTCTCTTTGGGATTGCTCAAGGG
GTCTATTTTATTGGGATTGGAGAGCGCATCTTAAAGTGTTTTGACTAG

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AJ428203

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_5_Locus:
22q11.2

# Macromolecular_Interacting_Partner_5_SNPs:
rs174369; rs174362; rs416422; rs394210; rs412830; rs5992068; rs9306195; rs411358; rs438858; rs174368; rs1296810; rs174367; rs174364; rs443694; rs2284827; rs1296813; rs9180; rs1044497; rs174365; rs5992747; rs174371; rs423158; rs174366; rs5747236; rs409842; rs443708; rs1296812; rs1296811; rs12483850; rs9604765; rs174363; rs13054020; rs1296807; rs404602; rs1296808; rs5746432; rs9618052; rs12106506; rs12106664; rs440661; rs12106622; rs5747237; rs12106497; rs2284826; rs12106547; rs7289980; rs8137960; rs5746439; rs5747244; rs1123031; rs8138249; rs5747240; rs7288387; rs1296816; rs8138125; rs2074343; rs8141183; rs8138271; rs1003494; rs12484916; rs174357; rs11704780; rs1296805; rs174358; rs16980869; rs695520; rs9618051; rs695715; rs28529249; rs35685254; rs7288704; rs34618306; rs695375; rs695611; rs34134204; rs12157687; rs35004938; rs5992745; rs7410497; rs11089188; rs12165490; rs695361; rs34815904; rs695683; rs12165499; rs5992070; rs36005837; rs9605327; rs34644606; rs12484668; rs695395; rs12329970; rs12165961; rs5992741; rs34691946; rs35680460; rs10460750; rs1296814; rs13053690; rs7289961; rs5992746; rs12169005; rs9604766; rs4819601; rs7292579; rs4819603; rs174360; rs36050117; rs8143114; rs7293105; rs695817; rs7410498; rs13057261; rs174370; rs174361; rs695291; rs390819; rs695292; rs12106649; rs1296809; rs5992744; rs12106495; rs5746433; rs695243; rs9618049; rs4819602; rs12162649; rs12165445; rs4819600; rs12159754; rs5992740; rs12168772; rs8142794; rs174359; rs12158291; rs35328239; rs34120048; rs12166900; rs8142221; rs1296817; rs4290742; rs5992071; rs4571160; rs13056690; rs5747241; rs695484; rs8141307; rs361999; rs8142020; rs34661208; rs4308195; rs2018000; rs372047; rs28630446; rs7290982; rs12158665; rs35511594; rs12166899; rs9618328; rs695588; rs5747242; rs34995295; rs433662; rs5992736; rs695758; rs34914325; rs5992737; rs5992067; rs5992738; rs1050583; rs1296819; rs1296820; rs1296822; rs1296823; rs1296826; rs1296829; rs16980870; rs16980879; rs16980884; rs174345; rs174346; rs174347; rs174348; rs174349; rs174350; rs174351; rs174352; rs2072555; rs2287228; rs2401157; rs4819608; rs5747232; rs5747247; rs5747252; rs5992735; rs5992749; rs5992750; rs5992751; rs714504; rs7511347; rs885971

# Macromolecular_Interacting_Partner_5_General_References:
11897791; 11381032

# Macromolecular_Interacting_Partner_5_References:
Not Available

# Macromolecular_Interacting_Partner_6_ID:
8680

# Macromolecular_Interacting_Partner_6_Name:
Excitatory amino acid transporter 1

# Macromolecular_Interacting_Partner_6_Synonyms:
Solute carrier family 1 member 3; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1

# Macromolecular_Interacting_Partner_6_Gene_Name:
SLC1A3

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Excitatory amino acid transporter 1
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIV
GTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMG
MRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPP
NLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNG
VNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGK
IVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITAL
GTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFE
LNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRT
TTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSET
KM

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
542

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
59573

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
8.69

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
 Function:  transporter activity
Function:  organic acid transporter activity
Function:  carboxylic acid transporter activity
Function:  dicarboxylic acid transporter activity
Function:  sodium:dicarboxylate symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  organic acid transport
Process:  carboxylic acid transport
Process:  dicarboxylic acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_6_Specific_Function:
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00375:SDF

# Macromolecular_Interacting_Partner_6_Signals:
Not Available

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
48-68
91-111
123-145
238-260
281-302
319-340

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
EAA1_HUMAN (P43003)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SLC1A3

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SLC1A3

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:10941

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
L19158

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_6_Locus:
5p13

# Macromolecular_Interacting_Partner_6_SNPs:
rs2032892; rs890922; rs2269272; rs1049524; rs1049522; rs4591778; rs7724801; rs13436644; rs13154397; rs2229894; rs6879542; rs10078147; rs1864214; rs2303716; rs1366638; rs2301065; rs1549627; rs1645660; rs1423677; rs2301068; rs891189; rs930072; rs1971720; rs1645651; rs2113098; rs1366632; rs2301067; rs366597; rs2301066; rs4869685; rs10070340; rs3776567; rs7712125; rs3903407; rs378427; rs7704118; rs372171; rs3776581; rs1428974; rs1864213; rs4869684; rs3776568; rs442867; rs7721893; rs7734056; rs7729402; rs2432213; rs2301064; rs7728680; rs4869676; rs753813; rs4869681; rs1001571; rs3776572; rs10941308; rs9292637; rs1030239; rs3733810; rs3776564; rs2364935; rs10941311; rs6451304; rs448281; rs3776565; rs3776586; rs3756468; rs16903252; rs3776573; rs10491375; rs3753180; rs17290929; rs10941306; rs12516475; rs11957945; rs12659371; rs17368211; rs17290638; rs3776577; rs10941309; rs3776583; rs3776566; rs13168598; rs3776576; rs371511; rs745429; rs7730373; rs13166160; rs1423679; rs1544795; rs3822469; rs6451303; rs4869683; rs1645658; rs4869486; rs3776578; rs1428968; rs7728030; rs2269271; rs3776587; rs3776569; rs10512660; rs3776579; rs1428967; rs2033267; rs13159713; rs2052885; rs4869677; rs10491374; rs16903198; rs3776585; rs4869682; rs4869680; rs11954014; rs9292638; rs16903247; rs10512661; rs10056001; rs16903222; rs12188287; rs3776570; rs16903237; rs10473034; rs369708; rs9283745; rs6892871; rs4869686; rs6881822; rs426040; rs1862638; rs2115523; rs10941312; rs11750072; rs1622132; rs2161608; rs3776563; rs16903256; rs9790917; rs3733811; rs11748249; rs10941313; rs16903262; rs12054904; rs13173144; rs10941310; rs13362437; rs2364932; rs3822468; rs2115522; rs7730537; rs3051481; rs379979; rs16903263; rs6868250; rs6896530; rs12518875; rs962686; rs745428; rs10057629; rs13179272; rs1423678; rs2033224; rs7729389; rs12518871; rs1423680; rs3756467; rs432268; rs3733812; rs10062853; rs3776571; rs10080178; rs2303715; rs1428975; rs12518891; rs16903205; rs10941307; rs4020423; rs2562581; rs2731886; rs1428973; rs2562582; rs3814068; rs9292636; rs10042564; rs3814067; rs11949360; rs11543905; rs34809305; rs17853737; rs35095566; rs35302142; rs11542585; rs2269273; rs1049520; rs6860949; rs34002322; rs1803715; rs6886600; rs5867331; rs10428531; rs11379538; rs35152088; rs3836803; rs6861465; rs17511061; rs10547870; rs35501123; rs35449337; rs3842036; rs1864212; rs35018051; rs7716057; rs11284735; rs35688678; rs11336594; rs10580203; rs35286117; rs10710837; rs34963761; rs5867333; rs11407453; rs13171136; rs6891580; rs10712185; rs34105781; rs34118681; rs35982078; rs3216728; rs34842454; rs7737476; rs7721587; rs35974769; rs35128248; rs10428554; rs13153345; rs13166338; rs35415040; rs4421131; rs5867334; rs1651849; rs34593765; rs17585568; rs36073020; rs6866248; rs35680188; rs1645657; rs34874003; rs35935808; rs34107449; rs581672; rs3216691; rs34789636; rs13166348; rs13361257; rs11321730; rs35658500; rs10069687; rs35685899; rs10038104; rs34594159; rs34495762; rs16903249; rs34862389; rs13170531; rs7726798; rs6872594; rs10079671; rs11409804; rs34710652; rs33984004; rs17368246; rs35558789; rs11285678; rs34433201; rs1651843; rs35937623; rs3776580; rs34686767; rs35350307; rs13185283; rs35191716; rs35578203; rs5867335; rs13178960; rs11361098; rs13166336; rs13164080; rs33955795; rs10637092; rs13166333; rs35394001; rs11284736; rs7710493; rs35507054; rs3833999; rs35654981; rs11286949; rs7732356; rs7703416; rs11292001; rs35209056; rs28458324; rs13355695; rs10473035; rs6862950; rs13170953; rs7713760; rs35761187; rs391031; rs11379742; rs5867332; rs7703852; rs34884619; rs34676530; rs13174138; rs12659296; rs1645659; rs12188037; rs34050141; rs35788656; rs10223091; rs41491650; rs11379803; rs3836802; rs35501352; rs8180423; rs28488541; rs34520204; rs6861244; rs13184339; rs34118423; rs381788; rs34955617; rs3051477; rs13184332; rs1428966; rs28447084; rs36124990; rs16903193; rs28491541; rs1122900; rs11741316; rs11743024; rs11743817; rs11953157; rs12189401; rs12651999; rs12654391; rs12654484; rs13155110; rs1366637; rs1529461; rs16903174; rs16903188; rs1995279; rs2562571; rs2562573; rs2562574; rs2562575; rs2562576; rs2562577; rs2562578; rs2562579; rs2562580; rs2731877; rs2731878; rs2731879; rs2731880; rs2731881; rs2731882; rs2731883; rs2731884; rs4443439; rs4527636; rs4532385; rs4869487; rs4869675; rs4869687; rs6451302; rs6863386; rs6887423; rs6896326; rs7703253; rs7704100; rs7730144; rs957904; rs957905

# Macromolecular_Interacting_Partner_6_General_References:
7521911; 8123008; 8647279

# Macromolecular_Interacting_Partner_6_References:
Not Available

# Macromolecular_Interacting_Partner_7_ID:
8693

# Macromolecular_Interacting_Partner_7_Name:
Calcium-binding mitochondrial carrier protein Aralar1

# Macromolecular_Interacting_Partner_7_Synonyms:
Mitochondrial aspartate glutamate carrier 1; Solute carrier family 25 member 12

# Macromolecular_Interacting_Partner_7_Gene_Name:
SLC25A12

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Calciumbinding mitochondrial carrier protein Aralar1
MAVKVQTTKRGDPHELRNIFLQYASTEVDGERYMTPEDFVQRYLGLYNDPNSNPKIVQLL
AGVADQTKDGLISYQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEVTFENVKEIFGQTII
HHHIPFNWDCEFIRLHFGHNRKKHLNYTEFTQFLQELQLEHARQAFALKDKSKSGMISGL
DFSDIMVTIRSHMLTPFVEENLVSAAGGSISHQVSFSYFNAFNSLLNNMELVRKIYSTLA
GTRKDVEVTKEEFAQSAIRYGQVTPLEIDILYQLADLYNASGRLTLADIERIAPLAEGAL
PYNLAELQRQQSPGLGRPIWLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGS
GSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRR
DGSVPLPAEVLAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLRDLGIFGL
YKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNLLAAGAMAGVPAASLVTPAD
VIKTRLQVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLAHYEV
LQRWFYIDFGGLKPAGSEPTPKSRIADLPPANPDHIGGYRLATATFAGIENKFGLYLPKF
KSPSVAVVQPKAAVAATQ

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
678

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
74757

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
8.56

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
 Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
Function:  transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  organelle membrane
Component:  organelle inner membrane
Component:  mitochondrial inner membrane

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Calcium-dependent mitochondrial aspartate and glutamate carrier. May have a function in the urea cycle

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00036:efhand
PF00153:Mito_carr

# Macromolecular_Interacting_Partner_7_Signals:
Not Available

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
330-347
391-410
434-447
483-502
522-539
579-598

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
3559910

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
CMC1_HUMAN (O75746)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
SLC25A12

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
SLC25A12

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:10982

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>2037 bp
ATGGCGGTCAAGGTGCAGACAACTAAGCGAGGGGATCCTCATGAGTTAAGAAACATATTT
CTACAGTATGCCAGTACTGAGGTTGATGGAGAGCGTTACATGACCCCAGAAGACTTTGTT
CAGCGCTATCTTGGACTGTATAATGATCCAAATAGTAACCCAAAGATCGTGCAGCTCTTG
GCAGGAGTAGCTGATCAAACCAAGGATGGGTTGATCTCCTATCAAGAGTTTTTGGCATTT
GAATCTGTTTTATGTGCTCCAGATTCCATGTTCATAGTGGCTTTCCAGTTGTTTGACAAG
AGTGGAAATGGAGAGGTGACATTTGAAAATGTCAAAGAAATTTTTGGACAGACTATTATT
CATCATCATATCCCTTTTAACTGGGATTGTGAATTTATCCGACTGCATTTTGGGCATAAC
CGGAAGAAGCATCTTAACTACACAGAATTCACGCAGTTTCTCCAGGAGCTGCAATTGGAA
CATGCAAGACAAGCCTTTGCACTCAAAGACAAAAGCAAAAGTGGCATGATTTCTGGTCTG
GATTTCAGTGACATCATGGTTACCATTAGATCTCACATGCTTACTCCTTTTGTGGAGGAG
AACTTAGTTTCAGCAGCTGGAGGAAGTATCTCACACCAGGTTAGCTTCTCCTACTTCAAT
GCATTTAACTCGTTACTGAATAACATGGAGCTTGTTCGTAAGATATATAGCACTCTAGCT
GGCACAAGGAAAGATGTTGAAGTCACAAAGGAGGAATTTGCCCAGAGTGCCATACGCTAT
GGACAAGTCACACCACTAGAAATTGATATTCTATATCAGCTTGCAGACTTATATAATGCT
TCAGGGCGCTTGACTTTGGCAGATATTGAGAGAATAGCCCCATTGGCTGAGGGGGCCTTA
CCTTACAACCTGGCAGAACTTCAGAGACAGCAGTCTCCTGGGTTAGGCAGGCCTATCTGG
CTCCAGATTGCCGAGTCTGCTTACAGATTCACTCTGGGCTCAGTTGCTGGAGCTGTGGGA
GCCACTGCAGTGTATCCTATAGATCTGGTGAAGACCCGAATGCAAAACCAGCGTGGCTCT
GGCTCTGTTGTTGGGGAGCTAATGTACAAAAACAGCTTTGACTGTTTTAAGAAAGTCTTG
CGTTATGAGGGCTTCTTTGGACTCTACAGGGGTCTGATACCACAACTTATAGGGGTTGCT
CCAGAAAAGGCCATTAAACTGACTGTTAATGATTTTGTTCGGGACAAATTTACCAGAAGA
GATGGCTCTGTTCCACTTCCAGCAGAAGTTCTTGCTGGAGGCTGTGCTGGAGGCTCTCAG
GTCATTTTTACCAACCCATTGGAGATAGTGAAGATTCGTCTGCAAGTAGCTGGAGAGATC
ACCACGGGACCCAGAGTCAGCGCCCTGAATGTGCTCCGGGACTTGGGAATTTTTGGTCTG
TATAAGGGTGCCAAAGCGTGTTTCCTCCGAGACATTCCCTTCTCTGCAATCTATTTTCCT
GTTTATGCTCATTGCAAACTACTTCTGGCTGATGAAAATGGACACGTGGGAGGTTTAAAT
CTTCTTGCAGCTGGAGCCATGGCAGGTGTCCCAGCTGCATCTCTGGTGACCCCTGCTGAT
GTCATCAAGACAAGACTGCAGGTGGCTGCCCGCGCTGGCCAGACGACATACAGTGGTGTC
ATCGACTGTTTCAGGAAGATTCTCCGGGAAGAAGGGCCCTCAGCATTTTGGAAAGGGACT
GCAGCTCGAGTGTTTCGATCCTCTCCCCAGTTTGGTGTTACCTTGGCTCATTATGAAGTT
CTCCAGCGGTGGTTTTACATTGATTTTGGAGGCCTCAAACCCGCTGGTTCAGAACCAACA
CCTAAGTCACGCATTGCAGACCTTCCTCCTGCCAACCCTGATCACATCGGTGGATACAGA
CTCGCCACAGCCACGTTTGCAGGCATCGAAAACAAATTTGGCCTTTATCTCCCGAAATTT
AAGTCTCCTAGTGTTGCTGTGGTTCAGCCAAAGGCAGCAGTGGCAGCCACTCAGTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
Y14494

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_7_Locus:
2q24

# Macromolecular_Interacting_Partner_7_SNPs:
rs35565687; rs1878583; rs11757; rs13035825; rs2292813; rs949548; rs908670; rs2271758; rs6433313; rs7608403; rs6725388; rs4668414; rs10930497; rs3770453; rs6745143; rs12692974; rs3770457; rs2056202; rs3770445; rs925881; rs12692973; rs12692978; rs7586207; rs3821096; rs3770451; rs7573003; rs6433315; rs3770455; rs3770452; rs12692976; rs970948; rs6754817; rs908671; rs2357064; rs10167419; rs3736499; rs3821093; rs12692977; rs3770458; rs1010533; rs3770449; rs3770448; rs6433317; rs12614709; rs13021138; rs3821095; rs12617655; rs1400816; rs7580232; rs11675404; rs3770459; rs3770444; rs3765166; rs6758704; rs6433314; rs2357206; rs6724337; rs12620126; rs6760680; rs12619067; rs3770443; rs6759575; rs6716901; rs12692979; rs3821092; rs17581284; rs2176466; rs7588025; rs6711813; rs1810338; rs1554259; rs17581439; rs1996424; rs1474074; rs11683867; rs2884123; rs17499593; rs11903123; rs7604821; rs6708365; rs3836018; rs11695029; rs3821094; rs3841888; rs10196521; rs3765167; rs6433316; rs1973706; rs17499864; rs1996425; rs9636293; rs1022358; rs7604933; rs2138872; rs17848721; rs7559830; rs12617265; rs3770450; rs10930495; rs7355523; rs17581347; rs13016580; rs17581361; rs11681772; rs11691344; rs6727459; rs925880; rs1973707; rs2276663; rs12990355; rs10803864; rs10930496; rs1105264; rs3770447; rs4668415; rs13018433; rs17615262; rs1105265; rs10191399; rs12619137; rs3836022; rs12622895; rs10497374; rs17499544; rs16859910; rs7355594; rs16859913; rs1059299; rs35881803; rs34360900; rs34495966; rs11383727; rs34728188; rs13410354; rs11319504; rs35917877; rs35734959; rs10183489; rs13384761; rs13386054; rs2138873; rs3058854; rs35240724; rs35085643; rs1106128; rs35884930; rs35854151; rs2138870; rs11467625; rs36075483; rs9808259; rs7603693; rs34985441; rs1810337; rs6707769; rs11458998; rs35883925; rs2176465; rs35571106; rs4668417; rs34070184; rs10545880; rs5836358; rs35252270; rs34370641; rs28796399; rs35493684; rs33956024; rs3836020; rs34957062; rs13419006; rs7603734; rs7593547; rs4668413; rs35488959; rs5836354; rs7355682; rs35898293; rs12105803; rs10700205; rs5836352; rs34551773; rs5836348; rs35136672; rs2176463; rs34056004; rs35208355; rs34221876; rs2176464; rs11442059; rs7608126; rs35628650; rs9749665; rs3059619; rs4027460; rs34797144; rs35087603; rs3836023; rs12470947; rs35540110; rs5836350; rs34431704; rs34541867; rs11397761; rs5836359; rs5836356; rs3951140; rs4027498; rs34924955; rs35592338; rs36000280; rs3770454; rs35030474; rs35465172; rs34870718; rs4668416; rs10174500; rs10557724; rs34563971; rs12617775; rs3765165; rs34663530; rs11450885; rs3058855; rs35712142; rs3836021; rs5836355; rs6709299; rs34184326; rs34327434; rs17848724; rs1829280; rs10179020; rs6736159; rs35087387; rs5836360; rs5836353; rs28748268; rs28379476; rs13022113; rs35336101; rs11392499; rs35057271; rs5836351; rs3836024; rs28810752; rs34833030; rs33946025; rs11344201; rs13017585; rs35978684; rs6726991; rs34388286; rs11428637; rs12991441; rs5836349; rs5836357; rs35801245; rs13021571; rs7592272; rs34467890; rs34203221; rs36102410; rs7584258; rs34295600; rs35860484; rs2138871; rs13025660; rs35160953; rs3836019; rs35288816; rs34962243; rs34276775; rs34494239; rs34108287; rs34139128; rs12053046; rs35160434; rs10646758; rs949648; rs13429367; rs34492103; rs10174525; rs1113390; rs6705200; rs6753859; rs7421773

# Macromolecular_Interacting_Partner_7_General_References:
9722566; 10369257; 11566871

# Macromolecular_Interacting_Partner_7_References:
Not Available

# Macromolecular_Interacting_Partner_8_ID:
8698

# Macromolecular_Interacting_Partner_8_Name:
Excitatory amino acid transporter 2

# Macromolecular_Interacting_Partner_8_Synonyms:
Solute carrier family 1 member 2; Sodium-dependent glutamate/aspartate transporter 2; Glutamate/aspartate transporter II

# Macromolecular_Interacting_Partner_8_Gene_Name:
SLC1A2

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Excitatory amino acid transporter 2
MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVC
GGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRA
MVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENL
VQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGM
NVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKI
IAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALG
TASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVL
DGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTS
VNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYA
AHNSVIVDECKVTLAANGKSADCSVEEEPWKREK

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
574

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
62105

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
6.51

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
 Function:  transporter activity
Function:  organic acid transporter activity
Function:  carboxylic acid transporter activity
Function:  dicarboxylic acid transporter activity
Function:  sodium:dicarboxylate symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  organic acid transport
Process:  carboxylic acid transport
Process:  dicarboxylic acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_8_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_8_Specific_Function:
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00375:SDF

# Macromolecular_Interacting_Partner_8_Signals:
Not Available

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
45-64
88-108
121-142
240-259
280-301
317-339
406-430
437-459

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
487341

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
EAA2_HUMAN (P43004)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
SLC1A2

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
SLC1A2

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:10940

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1725 bp
ATGGCATCTACGGAAGGTGCCAACAATATGCCCAAGCAGGTGGAAGTGCGAATGCCAGAC
AGTCATCTTGGCTCAGAGGAACCCAAGCACCGGCACCTGGGCCTGCGCCTGTGTGACAAG
CTGGGGAAGAATCTGCTGCTCACCCTGACGGTGTTTGGTGTCATCCTGGGAGCAGTGTGT
GGAGGGCTTCTTCGCTTGGCATCTCCCATCCACCCTGATGTGGTTATGTTAATAGCCTTC
CCAGGGGATATACTCATGAGGATGCTAAAAATGCTCATTCTCCCTCTAATCATCTCCAGC
TTAATCACAGGGTTGTCAGGCCTGGATGCTAAGGCTAGTGGCCGCTTGGGCACGAGAGCC
ATGGTGTATTACATGTCCACGACCATCATTGCTGCAGTACTGGGGGTCATTCTGGTCTTG
GCTATCCATCCAGGCAATCCCAAGCTCAAGAAGCAGCTGGGGCCTGGGAAGAAGAATGAT
GAAGTGTCCAGCCTGGATGCCTTCCTGGACCTTATTCGAAATCTCTTCCCTGAAAACCTT
GTCCAAGCCTGCTTTCAACAGATTCAAACAGTGACGAAGAAAGTCCTGGTTGCACCACCG
CCAGACGAGGAGGCCAACGCAACCAGCGCTGAAGTCTCTCTGTTGAACGAGACTGTGACT
GAGGTGCCGGAGGAGACTAAGATGGTTATCAAGAAGGGCCTGGAGTTCAAGGATGGGATG
AACGTCTTAGGTCTGATAGGGTTTTTCATTGCTTTTGGCATCGCTATGGGGAAGATGGGA
GATCAGGCCAAGCTGATGGTGGATTTCTTCAACATTTTGAATGAGATTGTAATGAAGTTA
GTGATCATGATCATGTGGTACTCTCCCCTGGGTATCGCCTGCCTGATCTGTGGAAAGATC
ATTGCAATCAAGGACTTAGAAGTGGTTGCTAGGCAACTGGGGATGTACATGGTAACAGTG
ATCATAGGCCTCATCATCCACGGGGGCATCTTTCTCCCCTTGATTTACTTTGTAGTGACC
AGGAAAAACCCCTTCTCCCTTTTTGCTGGCATTTTCCAAGCTTGGATCACTGCCCTGGGC
ACCGCTTCCAGTGCTGGAACTTTGCCTGTCACCTTTCGTTGCCTGGAAGAAAATCTGGGG
ATTGATAAGCGTGTGACTAGATTCGTCCTTCCTGTTGGAGCAACCATTAACATGGATGGT
ACAGCCCTTTATGAAGCGGTGGCCGCCATCTTTATAGCCCAAATGAATGGTGTTGTCCTG
GATGGAGGACAGATTGTGACTGTAAGCCTCACAGCCACCCTGGCAAGCGTCGGCGCGGCC
AGTATCCCCAGTGCCGGGCTGGTCACCATGCTCCTCATTCTGACAGCCGTGGGCCTGCCA
ACAGAGGACATCAGCTTGCTGGTGGCTGTGGACTGGCTGCTGGACAGGATGAGAACTTCA
GTCAATGTTGTGGGTGACTCTTTTGGGGCTGGGATAGTCTATCACCTCTCCAAGTCTGAG
CTGGATACCATTGACTCCCAGCATCGAGTGCATGAAGATATTGAAATGACCAAGACTCAA
TCCATTTATGATGACATGAAGAACCACAGGGAAAGCAACTCTAATCAATGTGTCTATGCT
GCACACAACTCTGTCATAGTAGATGAATGCAAGGTAACTCTGGCAGCCAATGGAAAGTCA
GCCGACTGCAGTGTTGAGGAAGAACCTTGGAAACGTGAGAAATAA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
U03505

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_8_Locus:
11p13-p12

# Macromolecular_Interacting_Partner_8_SNPs:
rs752949; rs1042113; rs1570216; rs10768121; rs10768122; rs4508184; rs16927196; rs11821067; rs3088168; rs10488814; rs16927202; rs3812778; rs7936950; rs12361171; rs12292131; rs10742339; rs3829280; rs1043101; rs12294045; rs3812779; rs12360706; rs2012996; rs1320443; rs2421765; rs1923305; rs911562; rs2273689; rs1570214; rs1923302; rs2273688; rs1923300; rs1885345; rs1923292; rs2421764; rs2281633; rs1885346; rs1923298; rs1321677; rs4756217; rs3903687; rs10501137; rs3847619; rs3847620; rs4756224; rs4755408; rs3899569; rs927352; rs10768131; rs4755395; rs10836372; rs10768129; rs3847607; rs7130967; rs4756205; rs7105505; rs4756216; rs3891872; rs7110985; rs10836383; rs7116961; rs10836360; rs10488817; rs11033081; rs4756223; rs3794100; rs1885340; rs3818275; rs3847623; rs3847621; rs4144753; rs2421955; rs7102122; rs4755394; rs10836370; rs10836374; rs10742347; rs4756218; rs4459280; rs7934466; rs3847609; rs4756211; rs10836379; rs1885342; rs4144754; rs10768132; rs10768127; rs4756203; rs1475079; rs10836373; rs11033079; rs12574069; rs3794101; rs10501138; rs10836361; rs7114383; rs10836376; rs3829266; rs7119430; rs7105690; rs7930134; rs7110991; rs7925926; rs4144755; rs7127824; rs7103668; rs3843610; rs2421897; rs4756222; rs7928425; rs3794102; rs4756214; rs2901534; rs3895234; rs7121587; rs6484774; rs6484777; rs911561; rs1570226; rs7106060; rs7115246; rs7108848; rs12273644; rs4593985; rs1923293; rs7124363; rs2025111; rs4755407; rs3847612; rs1001525; rs10836375; rs4756208; rs4083481; rs1923294; rs1570225; rs7107752; rs10836382; rs10836358; rs1885347; rs1570227; rs12294219; rs7102331; rs1923291; rs7931664; rs1320442; rs10836357; rs3847618; rs3794099; rs4756220; rs7942698; rs6484786; rs16927209; rs12269851; rs7127728; rs12417279; rs7106813; rs11033064; rs4755398; rs10836384; rs6484773; rs10742346; rs1570215; rs10836368; rs11033096; rs3847611; rs10836377; rs11033061; rs12416720; rs10742345; rs4756229; rs10488815; rs7124645; rs6484778; rs11033063; rs11033100; rs2901605; rs3847604; rs7119850; rs7114489; rs10836395; rs11033099; rs1126356; rs7120564; rs16927393; rs4083482; rs10836393; rs3794097; rs1885341; rs3903688; rs4756213; rs1923307; rs3945930; rs16927361; rs3794103; rs11827417; rs4756210; rs11033071; rs7111949; rs4756226; rs6484784; rs3925877; rs1923299; rs16927212; rs10836389; rs10768133; rs4756204; rs11033091; rs1923287; rs12279038; rs4756212; rs3843609; rs17378105; rs6484781; rs11033065; rs4756219; rs11033098; rs6484785; rs6484779; rs10836380; rs2633077; rs3794087; rs12796856; rs6484780; rs10444271; rs7939959; rs2756223; rs1885343; rs6484776; rs9704794; rs2093377; rs4756221; rs1885344; rs3794096; rs11033113; rs6484771; rs4559666; rs12794012; rs3847614; rs7952042; rs11033073; rs2065030; rs764750; rs6484783; rs7129352; rs10742341; rs16927309; rs10836366; rs4755406; rs4237664; rs4287314; rs3847615; rs3911898; rs3847624; rs11033088; rs2281634; rs3794089; rs7104229; rs7927263; rs7931955; rs10836378; rs7101653; rs10836386; rs2145906; rs16927304; rs3847610; rs11033070; rs11033105; rs4756230; rs6484782; rs10836394; rs4755409; rs4756228; rs3915513; rs7105829; rs10836387; rs4534557; rs4756207; rs7114936; rs11033097; rs11033048; rs2273687; rs7122811; rs6484772; rs17379710; rs11033114; rs10836381; rs3945931; rs7929900; rs7938735; rs5028776; rs12226211; rs11033055; rs3847605; rs11033110; rs7939421; rs7947035; rs16927281; rs7941569; rs11033115; rs7939877; rs2756220; rs10488816; rs12365407; rs11524863; rs7111179; rs7934047; rs1923306; rs7934506; rs7115450; rs10836362; rs7942586; rs10836369; rs3794092; rs7111043; rs7940391; rs10836367; rs7131582; rs4110478; rs4582949; rs7946149; rs3847617; rs2756218; rs16927292; rs11826870; rs3847606; rs12274790; rs11033117; rs12273257; rs12420201; rs16927465; rs10836390; rs4755396; rs12271153; rs3794098; rs7937731; rs3901811; rs11033053; rs3794086; rs2756222; rs3794090; rs11033087; rs10768128; rs3847622; rs12294149; rs16927464; rs7936564; rs3794095; rs3930590; rs12290338; rs957350; rs7120037; rs3847608; rs16927255; rs11033086; rs3858469; rs1923297; rs11033054; rs16927412; rs11033112; rs3794093; rs3794085; rs4756209; rs10836388; rs12276085; rs7926910; rs7927975; rs10836392; rs12576375; rs10742340; rs7131025; rs7942395; rs16927218; rs16927296; rs11033093; rs7123447; rs7102654; rs10488818; rs7945809; rs12274991; rs7945276; rs7926777; rs1923290; rs7927023; rs16927404; rs7938934; rs12418812; rs12276739; rs11033092; rs10768126; rs12275544; rs7926298; rs11033052; rs11033084; rs3794091; rs1923304; rs1923301; rs10742344; rs16927439; rs2421770; rs3847613; rs3103239; rs11033095; rs3858470; rs16927214; rs7949171; rs7111055; rs3794094; rs2273686; rs2025110; rs10768123; rs7943314; rs10836391; rs11033104; rs16927220; rs12276318; rs7115318; rs4756215; rs1923295; rs1321701; rs11033045; rs4354668; rs10836356; rs10768120; rs7130385; rs12270460; rs1042109; rs34076319; rs35538744; rs34298257; rs1042110; rs35330053; rs34674989; rs11033046; rs34684140; rs34511376; rs35111216; rs12016674; rs36089385; rs16927206; rs35463073; rs10742338; rs35754526; rs35860537; rs12270176; rs35277432; rs34253208; rs2901536; rs11601487; rs10836371; rs5791049; rs34019360; rs34278007; rs12286827; rs11033076; rs35890685; rs11033094; rs41525047; rs10611656; rs7929821; rs12802986; rs3931458; rs10691833; rs34099702; rs12290517; rs4756227; rs12271412; rs7940317; rs34199031; rs35859924; rs2421766; rs35195460; rs10594944; rs3838796; rs35313408; rs4755402; rs11033089; rs5791048; rs11343973; rs35772202; rs35344226; rs10694959; rs12292906; rs35520902; rs2756219; rs12290877; rs34538353; rs11387745; rs34676740; rs33995901; rs10684715; rs12786603; rs11428049; rs34154849; rs11033106; rs7936311; rs3215690; rs4755399; rs11352014; rs34607922; rs11033111; rs11033058; rs36055801; rs12364497; rs10570359; rs7944233; rs41282922; rs11033077; rs12573878; rs5791053; rs11440191; rs34940757; rs7119804; rs7109108; rs7926964; rs7938263; rs12576364; rs11033057; rs10668268; rs3833775; rs12281268; rs34327791; rs12283268; rs35628724; rs34479062; rs34492921; rs34408622; rs3833776; rs34340929; rs7103913; rs12803138; rs12226024; rs34269233; rs11033078; rs36213305; rs11820710; rs35491492; rs3847616; rs35893832; rs35603234; rs12289615; rs2756221; rs4755404; rs35511500; rs34091906; rs11826069; rs3888947; rs3911975; rs2901535; rs35839899; rs35743304; rs11452697; rs35828529; rs2421768; rs10571677; rs4756225; rs35644978; rs3899568; rs10531923; rs34253859; rs35889672; rs2421767; rs35055326; rs11430577; rs4755405; rs34015269; rs11033072; rs5013411; rs11033080; rs11033090; rs5791046; rs4329664; rs41427147; rs34046951; rs5791047; rs11033109; rs7105719; rs33976778; rs34184336; rs12574573; rs33939708; rs12270238; rs34663542; rs1923289; rs5791054; rs11365357; rs12801230; rs9667283; rs3046423; rs11033059; rs12796282; rs11033067; rs34651424; rs11033066; rs35260784; rs5791051; rs41352148; rs7945449; rs3046407; rs34421352; rs12802008; rs34486840; rs11406743; rs36008789; rs35092350; rs7107530; rs6144299; rs36078766; rs7131319; rs34874565; rs34336534; rs5791045; rs28492370; rs35662460; rs12798956; rs28670615; rs35121562; rs35605334; rs35677995; rs11033060; rs16927226; rs7115510; rs4755401; rs35500428; rs11033074; rs7480049; rs3794088; rs34807346; rs7110965; rs35373254; rs11297103; rs4465348; rs7114260; rs10618218; rs2421769; rs1923288; rs11033085; rs35394058; rs4328187; rs34210296; rs4444055; rs34788307; rs34714367; rs10685002; rs28687628; rs4755400; rs3934208; rs11033049; rs2273685; rs11033068; rs11459739; rs10653501; rs9736291; rs28373337; rs4331068; rs34697063; rs35584173; rs11033101; rs35175359; rs7125980; rs28682526; rs12285197; rs5014708; rs12800790; rs28542229; rs5791050; rs34461926; rs12800978; rs7938986; rs6484775; rs34651636; rs12226511; rs11033056; rs35007682; rs4439485; rs34358833; rs4996048; rs7102975; rs3049545; rs7939095; rs28564012; rs10685003; rs11033062; rs35034122; rs11033075; rs34236815; rs34058137; rs16927367; rs4755403; rs4755397; rs34057298; rs11822372; rs35798636; rs12293849; rs11033083; rs35870659; rs11404520; rs34110770; rs7119728; rs11343016; rs35256511; rs5028775; rs4477419; rs35382627; rs33945912; rs11344053; rs7936164; rs34861808; rs34471197; rs33913005; rs7931233; rs7130500; rs11033118; rs36087730; rs35261093; rs34449927; rs34780937; rs1042115; rs10488813; rs10768118; rs10768119; rs10768134; rs10768137; rs10836355; rs10836364; rs11033043; rs11033050; rs11604850; rs1173920; rs1173921; rs12146523; rs12281679; rs12287327; rs12417518; rs12421963; rs12573961; rs12577445; rs12786497; rs12808695; rs16927467; rs16927469; rs1923296; rs1923303; rs2236272; rs2236273; rs2236274; rs2421823; rs3763888; rs3763889; rs4472913; rs4503504; rs4755410; rs4756201; rs4756202; rs4756206; rs4756231; rs4756232; rs7102949; rs7104662; rs7104693; rs7108747; rs7117625; rs7122176; rs7122374; rs7122389; rs7122640; rs736374; rs7940304; rs932634; rs932635; rs9633870

# Macromolecular_Interacting_Partner_8_General_References:
7521911; 8172925; 7522567; 9463476

# Macromolecular_Interacting_Partner_8_References:
Not Available

# Macromolecular_Interacting_Partner_9_ID:
8739

# Macromolecular_Interacting_Partner_9_Name:
Glutamate--ammonia ligase domain-containing protein 1

# Macromolecular_Interacting_Partner_9_Synonyms:
Lengsin; Lens glutamine synthase-like

# Macromolecular_Interacting_Partner_9_Gene_Name:
GLULD1

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Glutamateammonia ligase domaincontaining protein 1
MNNEEDLLQEDSTRDEGNETEANSMNTLRRTRKKVTKPYVCSTEVGETDMSNSNDCMRDS
SQILTPPQLSSRMKHIRQAMAKNRLQFVRFEATDLHGVSRSKTIPAHFFQEKVSHGVCMP
RGYLEVIPNPKDNEMNNIRATCFNSDIVLMPELSTFRVLPWADRTARVICDTFTVTGEPL
LTSPRYIAKRQLSHLQASGFSLLSAFIYDFCIFGVPEILNSKIISFPALTFLNNHDQPFM
QELVDGLYHTGANVESFSSSTRPGQMEISFLPEFGISSADNAFTLRTGVKEVARKYNYIA
SFFIETGFCDSGILSHSLWDVDRKKNMFCSTSGTEQLTITGKKWLAGLLKHSAALSCLMA
PSVSCRKRYSKDRKDLKKSVPTTWGYNDNSCIFNIKCHGEKGTRIENKLGSATANPYLVL
AATVAAGLDGLHSSNEVLAGPDESTDFYQVEPSEIPLKLEDALVALEEDQCLRQALGETF
IRYFVAMKKYELENEEIAAERNKFLEYFI

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
509

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
57279

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
6.30

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
 Function:  acid-ammonia (or amide) ligase activity
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  acid-ammonia (or amide) ligase activity
Function:  ammonia ligase activity
Function:  glutamate-ammonia ligase activity
 ||
>>>
 Process:  nitrogen compound metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
Process:  glutamine biosynthesis
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_9_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_9_Specific_Function:
Not known

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00120:Gln-synt_C
PF03951:Gln-synt_N

# Macromolecular_Interacting_Partner_9_Signals:
Not Available

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
7341339

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
GLUD1_HUMAN (Q5TDP6)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
GLULD1

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
GLULD1

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:21016

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>1530 bp
ATGAATAATGAAGAGGACCTTCTGCAGGAGGACTCAACAAGAGATGAAGGCAATGAGACT
GAAGCCAACAGCATGAACACATTAAGAAGGACAAGGAAGAAAGTCACTAAACCATATGTT
TGTTCAACTGAAGTGGGAGAAACGGATATGTCCAATTCAAATGATTGCATGAGGGACAGC
AGTCAAATTTTGACCCCACCTCAACTCTCTTCTAGAATGAAACACATTAGACAAGCCATG
GCCAAAAATCGCCTCCAGTTTGTACGATTTGAAGCAACAGACCTCCACGGCGTGTCCAGG
TCTAAGACTATCCCTGCACACTTTTTTCAAGAGAAAGTGAGCCATGGTGTTTGCATGCCC
CGAGGTTATCTTGAAGTGATACCAAATCCAAAGGACAATGAAATGAATAACATAAGAGCC
ACATGTTTTAATAGCGACATAGTCCTAATGCCAGAGTTATCAACCTTTAGAGTTTTGCCA
TGGGCTGACAGAACTGCAAGAGTGATATGTGATACCTTCACTGTGACTGGTGAGCCTCTT
TTGACTTCCCCAAGGTACATTGCAAAGAGGCAGCTGAGCCATCTGCAGGCCTCTGGCTTT
TCCCTGCTTTCTGCTTTCATCTATGATTTTTGCATTTTTGGTGTGCCCGAAATTTTAAAT
TCAAAGATTATATCTTTTCCTGCTTTAACATTTTTAAATAACCATGATCAGCCCTTCATG
CAGGAACTTGTTGATGGCTTGTATCACACTGGAGCCAATGTCGAGAGTTTTTCCTCCTCT
ACCAGGCCTGGTCAGATGGAAATCTCTTTCCTGCCTGAATTTGGCATTAGCTCAGCTGAT
AATGCATTTACCCTCAGAACAGGTGTCAAAGAAGTGGCAAGGAAATATAATTACATTGCC
AGCTTCTTCATTGAGACTGGATTTTGTGATTCAGGGATTTTGTCTCATAGTCTCTGGGAT
GTCGATAGGAAGAAAAACATGTTCTGCAGCACTTCTGGAACTGAGCAGCTCACGATCACT
GGGAAAAAATGGTTGGCAGGACTCTTGAAGCACTCTGCTGCGCTCAGCTGCCTGATGGCG
CCTTCTGTTAGCTGCCGAAAGCGTTATTCCAAGGACAGGAAAGACCTGAAGAAGAGTGTG
CCTACAACATGGGGATACAATGACAACAGCTGTATATTTAATATCAAATGTCATGGAGAG
AAAGGCACCCGGATAGAAAATAAACTAGGCTCAGCAACAGCAAACCCTTACTTGGTGCTG
GCTGCAACTGTTGCTGCCGGCTTAGATGGACTTCATAGCAGTAATGAGGTCTTGGCTGGT
CCAGATGAGAGCACAGACTTTTACCAAGTGGAACCTTCTGAGATCCCTTTAAAACTAGAA
GATGCCCTTGTGGCACTGGAAGAAGATCAATGCCAGAGACAGGCTCTAGGAGAAACCTTT
ATTCGATATTTTGTTGCCATGAAGAAATATGAGTTGGAGAATGAAGAAATAGCTGCAGAG
AGAAATAAATTCTTAGAGTATTTTATTTAG

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
AF242388

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_9_Locus:
6pter-q22.33

# Macromolecular_Interacting_Partner_9_SNPs:
Not Available

# Macromolecular_Interacting_Partner_9_General_References:
14574404

# Macromolecular_Interacting_Partner_9_References:
Not Available

# Macromolecular_Interacting_Partner_10_ID:
8762

# Macromolecular_Interacting_Partner_10_Name:
Excitatory amino acid transporter 5

# Macromolecular_Interacting_Partner_10_Synonyms:
Solute carrier family 1 member 7; Retinal glutamate transporter

# Macromolecular_Interacting_Partner_10_Gene_Name:
SLC1A7

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Excitatory amino acid transporter 5
MVPHTILARGRDVCRRNGLLILSVLSVIVGCLLGFFLRTRRLSPQEISYFQFPGELLMRM
LKMMILPLVFSSLMSGLASLDAKTSSRLGVLTVAYYLWTTFMAVIVGIFMVSIIHPGSAA
QKETTEQSGKPIMSSADALLDLIRNMFPANLVEATFKQYRTKTTPVVKSPKVAPEEAPPR
RILIYGVQEENGSHVQNFALDLTPPPEVVYKSEPGTSDGMNVLGIVFFSATMGIMLGRMG
DSGGPLVSFCQCLNESVMKIVAVAVWYFPFGIVFLIAGKILEMDDPRAVGKKLGFYSVTV
VCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLIALATSSSSATLPITFKCLLENNH
IDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITGTAASIGAA
GIPQAGLVTMVIVLTSVGLPTDDITLIIGVDWALDRFRTMINVLGDALAAGIMAHICRKD
FARDTGTEKLLPCETKPVSLQEIVAAQQNGCVKSVAEASELTLGPTCPHHVPVQVERDEE
LPAASLNHCTIQISELETNV

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
560

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
60723

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
6.97

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
 Function:  transporter activity
Function:  organic acid transporter activity
Function:  carboxylic acid transporter activity
Function:  dicarboxylic acid transporter activity
Function:  sodium:dicarboxylate symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  organic acid transport
Process:  carboxylic acid transport
Process:  dicarboxylic acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_10_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_10_Specific_Function:
Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00375:SDF

# Macromolecular_Interacting_Partner_10_Signals:
1-34

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
17-37
60-80
94-114
217-237
260-280
300-320
330-350
372-392
414-434
457-477

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
2076762

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
EAA5_HUMAN (O00341)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
SLC1A7

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
SLC1A7

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:10945

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>1683 bp
ATGGTGCCGCATACCATCTTGGCACGGGGGAGGGACGTGTGCAGGCGGAATGGACTCCTC
ATCCTGTCTGTGCTGTCTGTCATCGTGGGCTGCCTCCTCGGCTTCTTCTTGAGGACCCGG
CGCCTCTCACCACAGGAAATTAGTTACTTCCAGTTCCCCGGAGAGCTCCTGATGAGGATG
CTGAAGATGATGATCCTGCCACTGGTGTTCTCCAGCTTGATGTCCGGACTTGCCTCCCTG
GATGCCAAGACCTCTAGCCGCCTGGGCGTCCTCACCGTGGCGTACTACCTGTGGACCACC
TTCATGGCTGTCATCGTGGGCATCTTCATGGTCTCCATCATCCACCCAGGCAGCGCGGCC
CAGAAGGAGACCACGGAGCAGAGTGGGAAGCCCATCATGAGCTCAGCCGATGCCCTGTTG
GACCTCATCCGGAACATGTTCCCAGCCAACCTAGTAGAAGCCACATTCAAACAGTACCGC
ACCAAGACCACCCCAGTTGTCAAGTCCCCCAAGGTGGCACCAGAGGAGGCCCCTCCTCGG
CGGATCCTCATCTACGGGGTCCAGGAGGAGAATGGCTCCCATGTGCAGAACTTCGCCCTG
GACCTGACCCCGCCGCCCGAGGTCGTTTACAAGTCAGAGCCGGGCACCAGCGATGGCATG
AATGTGCTGGGCATCGTCTTCTTCTCTGCCACCATGGGCATCATGCTGGGCCGCATGGGT
GACAGCGGGGGCCCCCTGGTCAGCTTCTGCCAGTGCCTCAATGAGTCGGTCATGAAGATC
GTGGCGGTGGCTGTGTGGTATTTCCCCTTCGGCATTGTGTTCCTCATTGCGGGTAAGATC
CTGGAGATGGACGACCCCAGGGCCGTCGGCAAGAAGCTGGGCTTCTACTCAGTCACCGTG
GTGTGCGGGCTGGTGCTCCACGGGCTCTTTATCCTGCCCCTGCTCTACTTCTTCATCACC
AAGAAGAATCCCATCGTCTTCATCCGCGGCATCCTGCAGGCTCTGCTCATCGCGCTGGCC
ACCTCCTCCAGCTCAGCCACACTGCCCATCACCTTCAAGTGCCTGCTGGAGAACAACCAC
ATCGACCGGCGCATCGCTCGCTTCGTGCTGCCCGTGGGTGCCACCATCAACATGGACGGC
ACTGCGCTCTACGAGGCTGTGGCCGCCATCTTCATCGCCCAGGTCAACAACTACGAGCTG
GACTTTGGCCAGATCATCACCATCAGTATCACAGGCACTGCAGCCAGCATTGGGGCAGCT
GGCATCCCCCAGGCCGGCCTCGTCACCATGGTCATCGTGCTCACCTCCGTGGGACTGCCC
ACCGATGACATCACCCTCATCATTGGCGTTGACTGGGCTCTGGACCGTTTCCGCACCATG
ATTAACGTGCTGGGTGATGCGCTGGCAGCGGGGATCATGGCCCATATATGTCGGAAGGAT
TTTGCCCGGGACACAGGCACCGAGAAACTGCTGCCCTGCGAGACCAAGCCAGTGAGCCTC
CAGGAGATCGTGGCAGCCCAGCAGAATGGCTGTGTGAAGAGTGTAGCCGAGGCCTCCGAG
CTCACCCTGGGCCCCACCTGCCCCCACCACGTCCCCGTTCAAGTGGAGCGGGATGAGGAG
CTGCCCGCTGCGAGTCTGAACCACTGCACCATCCAGATCAGCGAGCTGGAGACCAATGTC
TGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
U76362

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_10_Locus:
1p32.3

# Macromolecular_Interacting_Partner_10_SNPs:
rs1288401; rs1288406; rs12129653; rs1288400; rs3737989; rs17108032; rs2279275; rs11581058; rs1288399; rs3737990; rs1769299; rs1288420; rs1288404; rs1288405; rs2790428; rs936642; rs1317433; rs1288371; rs3766804; rs3766793; rs946593; rs1288403; rs7541073; rs11206094; rs1679971; rs6666264; rs11206098; rs1679938; rs7516241; rs1288373; rs1288408; rs2306459; rs1288422; rs1288419; rs3816744; rs1288367; rs1288370; rs1679977; rs1383600; rs7534682; rs3820201; rs6694834; rs1295456; rs3766767; rs2242274; rs1769309; rs946591; rs11587058; rs3766776; rs3753597; rs3766781; rs2404210; rs1288369; rs1679910; rs1679966; rs1288413; rs3766780; rs1288375; rs1288379; rs4926585; rs1679970; rs3766807; rs3766785; rs11583585; rs1288372; rs2404211; rs3766794; rs1679911; rs1288421; rs6677094; rs3766775; rs6664572; rs3766779; rs1288412; rs11206103; rs768771; rs12138818; rs922682; rs3766791; rs6666283; rs1288385; rs11206092; rs17377135; rs2242275; rs3753596; rs1679962; rs11206104; rs1300169; rs7556017; rs4926957; rs899976; rs11588325; rs12031385; rs3766792; rs11582599; rs4926953; rs11206109; rs11206100; rs1288410; rs1679963; rs12089128; rs1288380; rs1288358; rs10465824; rs1288425; rs12057760; rs10888765; rs1288383; rs17377317; rs11206095; rs12097449; rs12087013; rs1679976; rs6688914; rs3766795; rs12076660; rs1769308; rs1288416; rs11206101; rs1288424; rs3766790; rs1288354; rs1288365; rs11206108; rs10465825; rs4926955; rs17108022; rs11206107; rs11206099; rs1620182; rs3766782; rs12071908; rs6672896; rs1288376; rs10888767; rs1679974; rs11206106; rs10888766; rs13375492; rs3737988; rs1299859; rs3766774; rs11206093; rs7543888; rs1679965; rs1629126; rs1288384; rs1769304; rs17107989; rs4926586; rs2806274; rs12402097; rs6688627; rs3766800; rs3766778; rs11590819; rs1288418; rs931158; rs12096200; rs3766769; rs1769287; rs11206097; rs899975; rs1769303; rs1679937; rs1288382; rs12406773; rs3753593; rs3753600; rs1288414; rs4926959; rs1383599; rs1288377; rs1679973; rs1679964; rs10465822; rs12741022; rs1288374; rs6660952; rs12095038; rs17107994; rs12124028; rs2806271; rs1288381; rs922683; rs1769302; rs12092559; rs1288357; rs11206096; rs1288402; rs7530351; rs3753594; rs12403742; rs1288415; rs10465823; rs3766772; rs6694555; rs2790429; rs17108014; rs1769306; rs1679972; rs6588462; rs1288363; rs1288398; rs7549922; rs12042673; rs11206114; rs11206112; rs11206115; rs17107896; rs34418279; rs6701113; rs11206110; rs11206113; rs11206111; rs36059472; rs17850871; rs12021744; rs17850870; rs41312042; rs6658725; rs1047741; rs41298519; rs12726256; rs1769301; rs12738846; rs35659487; rs2306460; rs3835517; rs3766806; rs36087892; rs12132835; rs34240962; rs1288359; rs12094915; rs11206105; rs10664463; rs1769289; rs12738223; rs6678482; rs12031870; rs35072127; rs35847858; rs35003235; rs10649406; rs11402739; rs12751682; rs28475307; rs10582647; rs35401115; rs3121057; rs34256281; rs35058173; rs35193774; rs35757700; rs36097481; rs5774135; rs4926954; rs34450501; rs1629337; rs12759858; rs35617939; rs35966763; rs28545024; rs34866302; rs2929070; rs12733284; rs28497685; rs1021067; rs12759179; rs7555927; rs28665727; rs33933889; rs34043122; rs35510331; rs12736018; rs12097556; rs10465802; rs34963705; rs3766771; rs36059117; rs3091279; rs7414263; rs12028538; rs34978992; rs12751209; rs12753746; rs2929071; rs1288407; rs34800062; rs946592; rs35707549; rs28674862; rs2998095; rs3820202; rs28572521; rs35101975; rs34995823; rs35812030; rs34924909; rs4926584; rs12073825; rs34322627; rs34180199; rs12029289; rs12022300; rs35022560; rs6694665; rs28550100; rs34100876; rs36026049; rs11585963; rs12132883; rs12032008; rs35660302; rs6667002; rs10465826; rs12740055; rs28634935; rs10644085; rs11488222; rs5774136; rs35375670; rs35011578; rs12028535; rs1288355; rs6693952; rs11269357; rs1288366; rs12733497; rs34654701; rs12759482; rs12140504; rs34010895; rs2860608; rs1288417; rs35161056; rs12045217; rs12094913; rs34913378; rs12759321; rs34431109; rs36062616; rs36154040; rs36014120; rs28570358; rs34127376; rs17376904; rs35238020; rs6657444; rs34203701; rs936641; rs35112358; rs1288356; rs1769310; rs28697953; rs11485585; rs2998097; rs2998094; rs12144331; rs12136699; rs2929072; rs12737414; rs12760665; rs1769307; rs10582648; rs5774137; rs3766808; rs35128981; rs10537909; rs12028550; rs12240252; rs1288411; rs1679940; rs12032066; rs35336798; rs4926587; rs1288409; rs13376214; rs35499060; rs9436922; rs12028537; rs11299691; rs12757824; rs12067568; rs11417607; rs28850943; rs1288360; rs28647213; rs12753885; rs11424356; rs12751971; rs28507205; rs10465801; rs12126177; rs12753377; rs35110975; rs1288368; rs35957126; rs10888764; rs35777803; rs1288423; rs1626215; rs3121906; rs35838350; rs35036005; rs12760508; rs33958729; rs35644846; rs12736292; rs33959075; rs2998096; rs28546957; rs35258798; rs7545160; rs12031872; rs12725485; rs1679967; rs12752012; rs1288378; rs35213028; rs9436921; rs36025187; rs28627531; rs3766802; rs35778417; rs12733486; rs12062869; rs35061782; rs2306461; rs35057194; rs12751231; rs35599577; rs12737273; rs34925357; rs35697775; rs12119872; rs6664795; rs35816447; rs34983198; rs28367301; rs2998093; rs35175757; rs28451553; rs35867575; rs11206091; rs28418579; rs12043642; rs34669865; rs35707584; rs12040550; rs12028726; rs12744752; rs12727811; rs1288364; rs12750628; rs35866873; rs34798360; rs1001513; rs10157941; rs10888768; rs10888771; rs11206087; rs11206088; rs11206089; rs11206116; rs11206117; rs11579966; rs11803838; rs11804391; rs12070099; rs12074137; rs12074944; rs12123958; rs12143903; rs12567021; rs12723536; rs12745973; rs1288388; rs1288389; rs1288392; rs1288393; rs1288394; rs1288395; rs1288396; rs1288397; rs1320594; rs1628297; rs1679930; rs1679933; rs1679934; rs1679936; rs1679941; rs17107864; rs17107877; rs1769318; rs1769319; rs1769320; rs2282340; rs2486634; rs2806272; rs2806273; rs3121058; rs34163250; rs34248789; rs4576613; rs6691956; rs6696614; rs7552743; rs7553128; rs899973; rs899974; rs946590

# Macromolecular_Interacting_Partner_10_General_References:
9108121

# Macromolecular_Interacting_Partner_10_References:
Not Available

# Macromolecular_Interacting_Partner_11_ID:
8842

# Macromolecular_Interacting_Partner_11_Name:
Excitatory amino acid transporter 4

# Macromolecular_Interacting_Partner_11_Synonyms:
Solute carrier family 1 member 6; Sodium-dependent glutamate/aspartate transporter

# Macromolecular_Interacting_Partner_11_Gene_Name:
SLC1A6

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Excitatory amino acid transporter 4
MSSHGNSLFLRESGQRLGRVGWLQRLQESLQQRALRTRLRLQTMTLEHVLRFLRRNAFIL
LTVSAVVIGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASLD
NKATGRMGMRAAVYYMVTTIIAVFIGILMVTIIHPGKGSKEGLHREGRIETIPTADAFMD
LIRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGASMPPPFSVENGTSFLENV
TRALGTLQEMLSFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLN
EAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPL
IYFLVTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGA
TVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVL
TSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQEAELTLPSLG
KPYKSLMAQEKGASRGRGGNESAM

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
564

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
61567

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
9.54

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
 Function:  transporter activity
Function:  organic acid transporter activity
Function:  carboxylic acid transporter activity
Function:  dicarboxylic acid transporter activity
Function:  sodium:dicarboxylate symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  organic acid transport
Process:  carboxylic acid transport
Process:  dicarboxylic acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_11_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_11_Specific_Function:
Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF00375:SDF

# Macromolecular_Interacting_Partner_11_Signals:
Not Available

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
56-76
99-119
133-153
265-285
306-326
345-365
370-390
418-438
460-480
481-501

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
930337

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
EAA4_HUMAN (P48664)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
SLC1A6

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
SLC1A6

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:10944

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>1695 bp
ATGAGCAGCCATGGCAACAGCCTGTTCCTTCGGGAGAGCGGCCAGCGGCTGGGCCGGGTG
GGCTGGCTGCAGCGGCTGCAGGAAAGCCTGCAGCAGAGAGCACTGCGCACGCGCCTGCGC
CTGCAGACCATGACCCTCGAGCACGTGCTGCGCTTCCTGCGCCGAAACGCCTTCATTCTG
CTGACGGTCAGCGCCGTGGTCATTGGGGTCAGCCTGGCCTTTGCCCTGCGCCCATATCAG
CTCACCTACCGCCAGATCAAGTACTTCTCTTTTCCTGGAGAGCTTCTGATGAGGATGCTG
CAGATGCTGGTGTTACCTCTCATTGTCTCCAGCCTGGTCACAGGTATGGCATCCCTGGAC
AACAAGGCCACGGGGCGGATGGGGATGCGGGCAGCTGTGTACTACATGGTGACCACCATC
ATCGCGGTCTTCATCGGCATCCTCATGGTCACCATCATCCATCCCGGGAAGGGCTCCAAG
GAGGGGCTGCACCGGGAGGGCCGGATCGAGACCATCCCCACAGCTGATGCCTTCATGGAC
CTGATCAGAAATATGTTTCCACCAAACCTTGTGGAGGCCTGCTTCAAACAGTTCAAGACG
CAGTACAGCACGAGGGTGGTAACCAGGACCATGGTGAGGACAGAGAACGGGTCTGAGCCG
GGTGCCTCCATGCCTCCTCCATTCTCAGTGGAGAACGGAACCAGCTTCCTGGAAAATGTC
ACTCGGGCCTTGGGTACCCTGCAGGAGATGCTGAGCTTTGAGGAGACTGTACCCGTGCCT
GGCTCCGCCAATGGCATCAACGCCCTGGGCCTCGTGGTCTTCTCTGTGGCCTTTGGGCTG
GTCATTGGTGGCATGAAACACAAGGGCAGAGTCCTCAGGGACTTCTTCGACAGCCTCAAT
GAGGCTATTATGAGGCTGGTGGGCATCATTATCTGGTATGCACCTGTGGGCATCCTGTTC
CTGATTGCTGGGAAGATTCTGGAGATGGAAGACATGGCCGTCCTGGGGGGTCAGCTGGGC
ATGTACACCCTGACCGTCATCGTGGGCCTGTTCCTCCATGCCGGCATTGTCCTTCCCCTC
ATCTACTTCCTCGTCACTCACCGGAACCCCTTCCCCTTCATTGGGGGCATGCTACAAGCC
CTCATCACCGCTATGGGCACGTCTTCCAGCTCGGCAACGCTGCCCATCACCTTCCGCTGC
CTGGAGGAGGGCCTGGGTGTGGACCGCCGCATCACCAGGTTCGTCCTGCCCGTGGGCGCC
ACGGTCAACATGGATGGCACTGCCCTCTACGAGGCCCTGGCTGCCATCTTCATTGCTCAA
GTTAACAACTACGAGCTCAACCTGGGTCAGATCACAACCATCAGCATCACGGCCACAGCA
GCCAGTGTTGGGGCTGCTGGCATCCCCCAGGCGGGTCTGGTCACCATGGTCATTGTGCTT
ACGTCGGTCGGCTTGCCCACGGAAGACATCACGCTCATCATCGCCGTGGACTGGTTCCTT
GACCGGCTTCGCACAATGACCAACGTACTGGGGGACTCAATTGGAGCGGCCGTCATCGAG
CACTTGTCTCAGCGGGAGCTGGAGCTTCAGGAAGCTGAGCTTACCCTCCCCAGCCTGGGG
AAACCCTACAAGTCCCTCATGGCACAGGAGAAGGGGGCATCCCGGGGACGGGGAGGCAAC
GAGAGTGCTATGTGA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
U18244

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_11_Locus:
19p13.12

# Macromolecular_Interacting_Partner_11_SNPs:
rs3746295; rs16980148; rs2301853; rs12461006; rs2074615; rs2285980; rs12460353; rs873599; rs6511990; rs2285979; rs10417793; rs10403853; rs2189666; rs11671748; rs3803927; rs12460642; rs8108809; rs10408350; rs10415969; rs10407669; rs7253547; rs8108794; rs16980150; rs3815187; rs10415537; rs10406718; rs3827000; rs10410303; rs4511655; rs10401807; rs8109792; rs8112689; rs11668879; rs12463072; rs10403281; rs8113595; rs2097837; rs11669603; rs3746293; rs2189665; rs12972726; rs11673425; rs757465; rs10410180; rs7251228; rs10410626; rs2214603; rs2189664; rs2269913; rs12462958; rs7247183; rs12973581; rs10427099; rs1106738; rs4393693; rs2097836; rs7247531; rs11666283; rs7250478; rs16980152; rs12232794; rs11666968; rs4514810; rs2214602; rs7255650; rs757466; rs8105884; rs739962; rs2011112; rs3761099; rs8103212; rs2011132; rs8106695; rs739961; rs10419606; rs739963; rs7256150; rs3827006; rs3827005; rs3761100; rs10420206; rs3827007; rs10414644; rs35468001; rs3746294; rs34797512; rs3803928; rs5827266; rs10417230; rs10402958; rs34710555; rs34847096; rs35375672; rs36065519; rs35846543; rs2269914; rs12978810; rs2366859; rs12979472; rs36102075; rs34132116; rs34489581; rs12973102; rs10402960; rs2301854; rs10417023; rs35298524; rs35950893; rs2214601; rs12986049; rs34907139; rs7252057; rs12981490; rs5827267; rs12460957; rs10414225; rs12973558; rs35305816; rs35166598; rs12985848; rs11665949; rs12981997; rs12459441; rs12972461; rs34732384; rs3827002; rs35756560; rs35668831; rs3827004; rs12980319; rs3761101; rs5827264; rs3827003; rs3761098; rs5827265; rs11671614; rs11671616; rs34226419; rs34438988; rs28442191; rs13346179; rs1007503; rs1007504; rs1007505; rs11672838; rs1548543; rs1548545; rs16980139; rs1859384; rs4549003; rs7247514; rs7250612; rs8108343; rs8111088; rs8113325

# Macromolecular_Interacting_Partner_11_General_References:
7791878

# Macromolecular_Interacting_Partner_11_References:
Not Available

# Macromolecular_Interacting_Partner_12_ID:
8888

# Macromolecular_Interacting_Partner_12_Name:
Mitochondrial glutamate carrier 1

# Macromolecular_Interacting_Partner_12_Synonyms:
GC-1; Glutamate/H(+symporter 1; Solute carrier family 25 member 22

# Macromolecular_Interacting_Partner_12_Gene_Name:
SLC25A22

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Mitochondrial glutamate carrier 1
MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSE
GYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIV
TTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRS
RGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAA
VAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFG
IAQVVYFLGIAESLLGLLQDPQA

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
323

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
34471

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
9.67

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
 Function:  binding
Function:  transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  organelle membrane
Component:  organelle inner membrane
Component:  mitochondrial inner membrane

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+)

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF00153:Mito_carr

# Macromolecular_Interacting_Partner_12_Signals:
Not Available

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
12-32
107-127
189-209
223-243
292-312

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
21322705

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
GHC1_HUMAN (Q9H936)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
SLC25A22

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
SLC25A22

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:19954

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane; multi-pass membrane protein (Potential)

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>972 bp
ATGGCTGATAAGCAGATCAGCCTGCCAGCCAAGCTCATCAATGGCGGCATCGCCGGGCTG
ATCGGTGTCACCTGCGTGTTTCCCATCGACCTGGCCAAGACCAGGCTGCAGAACCAGCAG
AACGGCCAGCGCGTGTACACGAGCATGTCCGACTGCCTCATCAAGACCGTCCGCTCCGAG
GGCTACTTCGGCATGTACCGGGGAGCTGCTGTGAACTTGACCCTCGTCACCCCCGAGAAG
GCCATCAAGCTGGCAGCCAACGACTTCTTCCGACATCAGCTCTCTAAGGACGGGCAGAAG
CTGACCCTGCTTAAAGAGATGCTGGCGGGCTGTGGGGCTGGCACCTGCCAGGTGATCGTG
ACCACGCCCATGGAGATGCTGAAGATCCAGCTGCAGGATGCAGGGCGCATTGCCGCCCAG
AGGAAGATCCTGGCTGCCCAGGGCCAGCTCTCGGCCCAGGGGGGTGCCCAGCCCTCAGTG
GAGGCTCCAGCTGCCCCTCGGCCCACGGCCACCCAGCTGACCCGCGACCTGCTGCGGAGC
CGTGGCATTGCCGGTCTCTACAAGGGACTCGGGGCCACGCTGCTCAGGGATGTCCCCTTC
TCTGTGGTGTACTTCCCGCTCTTTGCCAACCTGAACCAGCTGGGCCGCCCGGCGTCCGAG
GAGAAGTCGCCTTTCTACGTGTCCTTCCTGGCCGGCTGTGTGGCTGGGAGTGCCGCCGCT
GTGGCCGTCAACCCCTGTGATGTGGTGAAGACGCGGCTCCAGTCACTTCAGCGAGGCGTC
AACGAGGACACCTACTCTGGGATCCTGGACTGTGCCAGGAAGATCCTGCGGCACGAGGGC
CCCTCGGCCTTCCTGAAGGGCGCCTACTGCCGCGCGCTGGTCATCGCGCCCCTTTTCGGC
ATCGCACAGGTGGTCTACTTCCTGGGCATCGCGGAGTCCCTGCTGGGGCTGCTGCAGGAC
CCCCAGGCCTGA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
AJ428202

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_12_Locus:
11p15.5

# Macromolecular_Interacting_Partner_12_SNPs:
Not Available

# Macromolecular_Interacting_Partner_12_General_References:
11897791

# Macromolecular_Interacting_Partner_12_References:
Not Available

End of HMDB00148

Beginning of HMDB00149
# Accession_No:
HMDB00149

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-22 10:59:58

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Ethanolamine

# Description:
A viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. It is used as a surfactant, fluorometric reagent, and to remove CO2 and H2S from natural gas and other gases.

# Synonyms:
1-Amino-2-hydroxyethane; 2-Amino-1-ethanol; 2-Aminoethanol; 2-Aminoethyl alcohol; 2-Ethanolamine; 2-Hydroxyethanamine; 2-Hydroxyethylamine; Aethanolamin; Aminoethanol; Colamine; ETA; Envision Conditioner PDD 9020; Ethanolamine; Ethylolamine; Glycinol; H-Glycinol; MEA; Monoaethanolamin; Monoethanolamine; Olamine; b-Aminoethanol; b-Aminoethyl alcohol; b-Ethanolamine; b-Hydroxyethylamine; beta-Aminoethanol; beta-Aminoethyl alcohol; beta-Hydroxyethylamine; beta-ethanolamine

# Chemical_IUPAC_Name:
2-aminoethanol

# Chemical_Formula:
C2H7NO

# Chemical_Structure:
tbl_chemical:::HMDB00149_ZOOM.png:::119283217848013077

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00149_THUMB.png:::119283217710426450

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary alcohol; 1,2-aminoalcohol; primary amine; primary aliphatic amine (alkylamine)

# Taxonomy_Biofunction:
Component of Glycerophospholipid metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
61.05277

# Molecular_Weight_Avg:
61.08308

# Smiles_String_isomeric:
NCCO

# Smiles_String_canonical:
NCCO

# KEGG_Compound_ID:
C00189

# BioCyc_ID:
ETHANOL-AMINE

# PubChem_CID:
700

# PubChem_SID:
583749; 3489; 7887366; 829228; 3135188; 7853406; 583803; 819289; 539754; 5159580; 10323821; 826817; 830565; 2689; 587681; 151996; 8150749; 7988427; 835254; 8145052; 543442; 546002; 583747; 7849610; 14709284; 10507781; 583871; 11108730; 841590

# OMIM_ID:
227150

# Metagene_ID:
HYPOPHOSPHATASIA: 440; ETHANOLAMINOSIS: 132

# BiGG_ID:
34189

# Wikipedia_ID:
Ethanolamine

# METLIN_ID:
3207

# Ref_ID:
7895605; 2116174; 8443564; 1504837; 2896652; 4295349; 8581486; 10502752; 9130265; 1841636; 12834252

# ChEBI_ID:
16000

# CAS_Registry_Number:
141-43-5

# InChI:
InChI=1/C2H7NO/c3-1-2-4/h4H,1-3H2

# Synthesis_Reference:
Journal of the American Chemical Society  (1950),  72  2866-7.

# Melting_Point:
10.5 oC

# Melting_Point_predicted:
14.6 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1000.0 mg/mL [RIDDICK,JA et al. (1986)]

# H2O_Solubility_Predicted:
849.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
1

# State:
Liquid

# LogP:
-1.31 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-1.52 [Predicted by ALOGPS]; -1.3 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Ethanolamine.pdf:::1132562206338763925

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Ethanolamine.mol:::1132723810093836255

# SDF_File_[Text]:
tbl_chemical:::HMDB00149.sdf:::119283217427260683

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00149.pdb:::119283217574147612

# PDB_ID:
1AII

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041028_P00_01_HW_1DP_presat.png:::114866289466624125

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041028_P00_01_HW_1DP_presat_1.zip:::114719678163487615

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041028_P00_01_HW_1DP_Assigned.png:::114781612994642684

# C_NMR_Spectra:
tbl_cnmr:::041028_P00_01_HW_1DC_115.jpg:::114168459595284775

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041028_P00_01_HW_1DC_115.zip:::114168459591161149

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041028_P00_01_HW_1DC_115_Assigned.jpg:::114332869006317903

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041028_P00_01_HW_2DHSQC_419.jpg:::114617358040987296

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041028_P00_01_HW_2DHSQC_419.zip:::114617358041876659

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041028_P00_01_HW_2DHSQC_419_Assigned.jpg:::114781521700692171

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Ethanolamine.gif:::1132732114000165485

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00149_peaks.txt:::1156309576169404141

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Ethanolamine_C.gif:::1132737699728357819

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00149_peaks.txt:::1156310766041925103

# Mass_Spectrum:
tbl_chemical:::HMDB00149.jpg:::1132798876937874564

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000276.png:::116907445501591096

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000276.txt:::116907445501585817

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000276.png:::116890834053170431

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000276.txt:::11689083408282002

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Brain; Epidermis; Most Tissues; Myelin; Nerves; Pancreas; Stratum Corneum

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	21.4 (6.579-36.2)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Blood	52.3 (26.2-91.7)	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	1.6 (0.0-11.5)	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	14.1 +/- 3.0	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	8.43 (2.62-14.24)	umol/L	Adult:>18_yrs_old	Both	Normal	12834252


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Not Available

# Pathway_Names:
Glycerophospholipid metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00564

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
6137

# Metabolic_Enzyme_1_Name:
Ethanolamine kinase 1

# Metabolic_Enzyme_1_Synonyms:
EKI 1

# Metabolic_Enzyme_1_Gene_Name:
ETNK1

# Metabolic_Enzyme_1_Protein_Sequence:
>Ethanolamine kinase 1
MLCGRPRSSSDNRNFLRERAGLSSAAVQTRIGNSAASRRSPAARPPVPAPPALPRGRPGT
EGSTSLSAPAVLVVAVAVVVVVVSAVAWAMANYIHVPPGSPEVPKLNVTVQDQEEHRCRE
GALSLLQHLRPHWDPQEVTLQLFTDGITNKLIGCYVGNTMEDVVLVRIYGNKTELLVDRD
EEVKSFRVLQAHGCAPQLYCTFNNGLCYEFIQGEALDPKHVCNPAIFRLIARQLAKIHAI
HAHNGWIPKSNLWLKMGKYFSLIPTGFADEDINKRFLSDIPSSQILQEEMTWMKEILSNL
GSPVVLCHNDLLCKNIIYNEKQGDVQFIDYEYSGYNYLAYDIGNHFNEFAGVSDVDYSLY
PDRELQSQWLRAYLEAYKEFKGFGTEVTEKEVEILFIQVNQFALASHFFWGLWALIQAKY
STIEFDFLGYAIVRFNQYFKMKPEVTALKVPE

# Metabolic_Enzyme_1_Number_of_Residues:
452

# Metabolic_Enzyme_1_Molecular_Weight:
50969

# Metabolic_Enzyme_1_Theoretical_pI:
6.51

# Metabolic_Enzyme_1_GO_Classification:
Not Available

# Metabolic_Enzyme_1_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_1_Specific_Function:
Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis

# Metabolic_Enzyme_1_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_1_Reaction:
ATP + ethanolamine = ADP + O-phosphoethanolamine

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01633:Choline_kinase

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
66-88

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.7.1.82

# Metabolic_Enzyme_1_GenBank_ID_Protein:
9998952

# Metabolic_Enzyme_1_SwissProt_ID:
EKI1_HUMAN (Q9HBU6)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ETNK1

# Metabolic_Enzyme_1_Geneatlas_id:
ETNK1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:24649

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1359 bp
ATGCTCTGCGGCCGCCCGCGGTCCAGCTCCGACAACAGGAATTTTCTCCGAGAGCGGGCC
GGGCTCAGTTCAGCTGCTGTCCAGACCCGGATCGGCAACAGTGCCGCCTCCAGACGTTCT
CCTGCCGCTCGCCCGCCCGTCCCAGCGCCCCCAGCCCTCCCGCGAGGGCGCCCCGGGACG
GAAGGATCCACCAGTCTGTCGGCGCCCGCCGTTCTCGTGGTCGCCGTCGCCGTCGTCGTG
GTGGTAGTCTCCGCCGTCGCCTGGGCCATGGCCAATTACATCCACGTCCCTCCCGGCTCC
CCGGAGGTGCCCAAGCTGAACGTCACCGTTCAGGATCAGGAGGAGCATCGCTGCCGGGAG
GGGGCCCTGAGCCTCCTGCAACACCTGCGGCCTCACTGGGACCCCCAGGAGGTGACCCTG
CAGCTCTTCACAGATGGAATCACAAATAAACTTATTGGCTGTTACGTGGGAAACACCATG
GAGGATGTAGTCCTGGTGAGAATTTATGGCAATAAGACTGAGTTATTAGTCGATCGAGAT
GAGGAAGTAAAGAGTTTTCGAGTGTTGCAGGCTCATGGGTGTGCACCACAACTCTACTGT
ACCTTCAATAATGGACTATGCTATGAATTTATACAAGGAGAAGCACTGGATCCAAAGCAT
GTCTGCAACCCAGCCATTTTCAGGCTAATAGCTCGTCAGCTTGCTAAAATCCATGCTATT
CATGCACACAATGGCTGGATCCCCAAATCTAATCTTTGGCTAAAGATGGGAAAGTATTTC
TCTCTCATTCCCACAGGATTTGCAGATGAAGACATTAATAAAAGGTTCCTAAGTGATATC
CCAAGCTCTCAGATTCTCCAGGAAGAGATGACTTGGATGAAGGAGATTCTTTCCAACCTG
GGCTCACCTGTTGTGCTTTGCCATAATGACCTATTGTGTAAGAATATAATCTACAATGAG
AAACAAGGTGATGTACAGTTCATTGATTATGAATATTCTGGATACAACTACCTGGCATAT
GATATTGGAAATCATTTCAATGAATTTGCAGGTGTGAGTGATGTAGACTATAGTCTGTAT
CCAGATAGAGAACTACAGAGTCAGTGGCTGCGTGCTTACCTTGAAGCCTACAAAGAATTT
AAGGGCTTTGGGACTGAAGTTACTGAAAAGGAGGTAGAAATACTCTTCATTCAAGTCAAT
CAGTTTGCATTGGCTTCTCATTTCTTTTGGGGATTGTGGGCTTTGATTCAAGCCAAATAC
TCCACTATTGAGTTTGATTTCCTTGGGTATGCAATTGTTCGTTTTAACCAGTACTTTAAA
ATGAAGCCTGAGGTTACTGCATTAAAAGTGCCTGAGTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF207600

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_1_Locus:
12p12.1

# Metabolic_Enzyme_1_SNPs:
rs4963793; rs9435; rs2129613; rs11541361; rs11046536; rs16925301; rs3741784; rs16925296; rs11046535; rs734775; rs261912; rs12301700; rs10842041; rs10842046; rs7297546; rs10770910; rs4482079; rs2271098; rs4963842; rs10842042; rs10770914; rs8181769; rs4963827; rs1487428; rs10842050; rs2271099; rs10770911; rs734774; rs12308196; rs12308546; rs7296836; rs192336; rs923280; rs12308946; rs12319840; rs12305738; rs11046514; rs16925289; rs11046516; rs16925287; rs10505886; rs16925217; rs12300802; rs16925282; rs12296448; rs12303218; rs11046523; rs7302103; rs11046510; rs17426308; rs10770912; rs10842048; rs11046513; rs12298972; rs11046524; rs4963788; rs11046511; rs10842045; rs10842044; rs10842039; rs17349043; rs11046525; rs12299284; rs11046531; rs10842047; rs12299764; rs2271097; rs16925264; rs11046506; rs7954733; rs7966956; rs7133091; rs7970594; rs7954762; rs7954992; rs8181655; rs12299426; rs7966958; rs11046512; rs12306164; rs16925261; rs10842043; rs11046532; rs12306607; rs7970453; rs12319186; rs7954993; rs261913; rs11046508; rs7132046; rs16925259; rs7954355; rs12317631; rs7966834; rs12314263; rs7956605; rs11046533; rs11046505; rs11046527; rs16925248; rs7979446; rs12301679; rs7315482; rs16925255; rs16925281; rs10842049; rs7966911; rs10842040; rs171888; rs2046602; rs10770913; rs16925270; rs1506787; rs11046504; rs7954188; rs12296341; rs7971005; rs16925251; rs7954174; rs11046507; rs17348380; rs656827; rs3923695; rs17341505; rs3809196; rs7303466; rs3809195; rs34032941; rs11548473; rs35352240; rs3983448; rs11046538; rs1048796; rs34286505; rs1048797; rs12316161; rs11046537; rs34490298; rs34050861; rs35073632; rs12312458; rs11046539; rs11046540; rs12317915; rs596408; rs11046534; rs34881814; rs16925249; rs28547537; rs10586779; rs35243907; rs261914; rs35183381; rs11615659; rs2135607; rs10591477; rs4453283; rs11046520; rs34297887; rs11046518; rs34066257; rs35968205; rs35937176; rs183791; rs190512; rs28408391; rs12317627; rs11046501; rs676121; rs583600; rs12825477; rs5796966; rs11046530; rs261915; rs11046519; rs12308999; rs11046521; rs11046526; rs12299625; rs35573073; rs35216703; rs1685223; rs174437; rs35736263; rs11429701; rs11046528; rs12229952; rs12321125; rs28690549; rs12317683; rs12811013; rs34533040; rs35113697; rs12370251; rs11046529; rs35524221; rs35502946; rs12824640; rs10047544; rs11046517; rs11046503; rs17427520; rs12578734; rs2135606; rs12317298; rs3825255; rs9645727; rs35599018; rs34705846; rs12322145; rs630588; rs12299356; rs11046515; rs7976169; rs12296879; rs3983455; rs12826684; rs11433318; rs1472824; rs190513; rs12321044; rs12315107; rs35208201; rs7314651; rs35097986; rs12315129; rs626181; rs11046509; rs34202945; rs34386705; rs185491; rs35623725; rs9651817; rs34135611; rs12582387; rs2135605; rs12314129; rs647446; rs34991057; rs11046502; rs35902446; rs35849050; rs34035154; rs12321003; rs7135431; rs35611431; rs34234701; rs12310925; rs12830503; rs34986988; rs7134326; rs7302490; rs3839977; rs35869773; rs10743443; rs10770917; rs10842053; rs11046498; rs11046500; rs12812553; rs12814947; rs261918; rs587173; rs587625; rs663971; rs665236

# Metabolic_Enzyme_1_General_References:
11044454

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5309

# Metabolic_Enzyme_2_Name:
Phospholipase D2

# Metabolic_Enzyme_2_Synonyms:
PLD 2; Choline phosphatase 2; Phosphatidylcholine-hydrolyzing phospholipase D2; PLD1C; hPLD2

# Metabolic_Enzyme_2_Gene_Name:
PLD2

# Metabolic_Enzyme_2_Protein_Sequence:
>Phospholipase D2
MTATPESLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQSLKVHPLVFA
PGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVL
MSLLPLARFAVAYSPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYR
NYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVV
KDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSLILKCSSYRQAR
WWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIF
ITDWWLSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRAL
MLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSSE
SAASQPPTPRPDSPATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPW
RDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKSTSTANQLPFTLPGGQ
CTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDE
IVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHR
LKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTVIIGSANINDRSLL
GKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILGANTRPDLDLRDPICD
DFFQLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQ
GHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT

# Metabolic_Enzyme_2_Number_of_Residues:
933

# Metabolic_Enzyme_2_Molecular_Weight:
105988

# Metabolic_Enzyme_2_Theoretical_pI:
7.68

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
May have a role in signal-induced cytoskeletal regulation and/or endocytosis

# Metabolic_Enzyme_2_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_2_Reaction:
A phosphatidylcholine + H2O = choline + a phosphatidate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00169:PH;
PF00614:PLDc;
PF00787:PX

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.1.4.4

# Metabolic_Enzyme_2_GenBank_ID_Protein:
2645858

# Metabolic_Enzyme_2_SwissProt_ID:
PLD2_HUMAN (O14939)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
PLD2

# Metabolic_Enzyme_2_Geneatlas_id:
PLD2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:9068

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Membrane; peripheral membrane protein

# Metabolic_Enzyme_2_Gene_Sequence:
>2802 bp
ATGACGGCGACCCCTGAGAGCCTCTTCCCCACTGGGGACGAACTGGACTCCAGCCAGCTC
CAGATGGAGTCCGATGAGGTGGACACCCTGAAGGAGGGAGAGGACCCAGCCGACCGGATG
CACCCGTTTCTGGCCATCTATGAGCTTCAGTCTCTGAAAGTGCACCCCTTGGTGTTCGCA
CCTGGGGTCCCTGTCACAGCCCAGGTGGTGGGCACCGAAAGATATACCAGCGGATCCAAG
GTGGGAACCTGCACTCTGTATTCTGTCCGCTTGACTCACGGCGACTTTTCCTGGACAACC
AAGAAGAAATACCGTCATTTTCAGGAGCTGCATCGGGACCTCCTGAGACACAAAGTCTTG
ATGAGTCTGCTCCCTCTGGCTCGATTTGCCGTTGCCTATTCTCCAGCCCGAGATGCAGGC
AACAGAGAGATGCCCTCTCTACCCCGGGCAGGTCCTGAGGGCTCCACCAGACATGCAGCC
AGCAAACAGAAATACCTGGAGAATTACCTCAACTGTCTCTTGACCATGTCTTTCTATCGC
AACTACCATGCCATGACAGAGTTCCTGGAAGTCAGTCAGCTGTCCTTTATCCCGGACTTG
GGCCGCAAAGGACTGGAGGGGATGATCCGGAAGCGCTCAGGTGGCCACCGTGTTCCTGGC
CTCACCTGCTGTGGCCGAGACCAAGTTTGTTATCGCTGGTCCAAGAGGTGGCTGGTGGTG
AAGGACTCCTTCCTGCTGTACATGTGCCTCGAGACAGGTGCCATCTCATTTGTTCAGCTC
TTTGACCCTGGCTTTGAGGTGCAAGTGGGGAAAAGGAGCACGGAGGCACGGCACGGCGTG
CGGATCGATACCTCCCACAGGTCCTTGATTCTCAAGTGCAGCAGCTACCGGCAGGCACGG
TGGTGGGCCCAAGAGATCACTGAGCTGGCACAGGGCCCAGGCAGAGACTTCCTACAGCTG
CACCGGCATGACAGCTACGCCCCACCCCGGCCTGGGACCTTGGCCCGGTGGTTTGTGAAT
GGGGCAGGTTACTTTGCTGCTGTGGCAGATGCCATCCTTCGAGCTCAAGAGGAGATTTTC
ATCACAGACTGGTGGTTGAGTCCTGAGGTTTACCTGAAGCGTCCGGCCCATTCAGATGAC
TGGAGACTGGACATTATGCTCAAGAGGAAGGCGGAGGAAGGTGTCCGTGTGTCTATTCTG
CTGTTTAAAGAAGTGGAATTGGCCTTGGGCATCAACAGTGGCTATAGCAAGAGGGCGCTG
ATGCTGCTGCACCCCAACATAAAGGTGATGCGTCACCCAGACCAAGTGACGTTGTGGGCC
CATCATGAGAAGCTCCTGGTGGTGGACCAAGTGGTAGCATTCCTGGGGGGACTGGACCTT
GCCTATGGCCGCTGGGATGACCTGCACTACCGACTGACTGACCTTGGAGACTCCTCTGAA
TCAGCTGCCTCCCAGCCTCCCACCCCGCGCCCAGACTCACCAGCCACCCCAGACCTCTCT
CACAACCAATTCTTCTGGCTGGGCAAGGACTACAGCAATCTTATCACCAAGGACTGGGTG
CAGCTGGACCGGCCTTTCGAAGATTTCATTGACAGGGAGACGACCCCTCGGATGCCATGG
CGGGACGTTGGGGTGGTCGTCCATGGCCTACCGGCCCGGGACCTTGCCCGGCACTTCATC
CAGCGCTGGAACTTCACCAAGACCACCAAGGCCAAGTACAAGACTCCCACATACCCCTAC
CTGCTTCCCAAGTCTACCAGCACGGCCAATCAGCTCCCCTTCACACTTCCAGGAGGGCAG
TGCACCACCGTACAGGTCTTGCGATCAGTGGACCGCTGGTCAGCAGGGACTCTGGAGAAC
TCCATCCTCAATGCCTACCTGCACACCATCAGGGAGAGCCAGCACTTCCTCTACATTGAG
AATCAGTTCTTCATTAGCTGCTCAGATGGGCGGACGGTTCTGAACAAGGTGGGCGATGAG
ATTGTGGACAGAATCCTGAAGGCCCACAAACAGGGGTGGTGTTACCGAGTCTACGTGCTT
TTGCCCTTACTCCCTGGCTTCGAGGGTGACATCTCCACGGGCGGTGGCAACTCCATCCAG
GCCATTCTGCACTTTACTTACAGGACCCTGTGTCGTGGGGAGTATTCAATCCTGCATCGC
CTTAAAGCAGCCATGGGGACAGCATGGCGGGACTATATTTCCATCTGCGGGCTTCGTACA
CACGGAGAGCTGGGCGGGCACCCCGTCTCGGAGCTCATCTACATCCACAGCAAGGTGCTC
ATCGCAGATGACCGGACAGTCATCATTGGTTCTGCAAACATCAATGACCGGAGCTTGCTG
GGGAAGCGGGACAGTGAGCTGGCCGTGCTGATCGAGGACACAGAGACGGAACCATCCCTC
ATGAATGGGGCAGAGTATCAGGCGGGCAGGTTTGCCTTGAGTCTGCGGAAGCACTGCTTC
GGTGTGATTCTTGGAGCAAATACCCGGCCAGACTTGGATCTCCGAGACCCCATCTGTGAT
GACTTCTTCCAGTTGTGGCAAGACATGGCTGAGAGCAACGCCAATATCTATGAGCAGATC
TTCCGCTGCCTGCCATCCAATGCCACGCGTTCCCTGCGGACTCTCCGGGAGTACGTGGCC
GTGGAGCCCTTGGCCACGGTCAGTCCCCCCTTGGCTCGGTCTGAGCTCACCCAGGTCCAG
GGCCACCTGGTCCACTTCCCCCTCAAGTTCCTAGAGGATGAGTCTTTGCTGCCCCCGCTG
GGTAGCAAGGAGGGCATGATCCCCCTAGAAGTGTGGACATAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF033850

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_2_Locus:
17p13.1

# Metabolic_Enzyme_2_SNPs:
rs3764897; rs1052748; rs2286672; rs1052751; rs7211943; rs1132448; rs3867173; rs7212512; rs2875840; rs3764899; rs2286671; rs11078539; rs6502824; rs3853646; rs2302327; rs2302325; rs3764900; rs2875841; rs11656427; rs2286670; rs3786043; rs11658292; rs11658287; rs3786041; rs4790233; rs4790709; rs12936266; rs2302326; rs3888339; rs4790234; rs4566240; rs17854914; rs2302323; rs11545163; rs1132447; rs1052746; rs3178169; rs1052742; rs3081358; rs35439858; rs1052779; rs35937990; rs5818989; rs36231931; rs2875842; rs36229113; rs5818990; rs1052755; rs34361510; rs35608631; rs3786042; rs35190261; rs35037094; rs3081314; rs3889229; rs2286669; rs7212717; rs28585446; rs9635707; rs2302324; rs2326097; rs35472015; rs2326088; rs7213994; rs35410162; rs34011348; rs12452111; rs9635706; rs2326098; rs3835027; rs3841515; rs9635705; rs34698829; rs34336549; rs34834883; rs2326087; rs4790707; rs34921470; rs35305168; rs1050296; rs11654671; rs11654690; rs12453110; rs1804248; rs2304974; rs2304975; rs4053369; rs4053373; rs7468

# Metabolic_Enzyme_2_General_References:
9761774; 9582313

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6056

# Metabolic_Enzyme_3_Name:
Choline/ethanolamine kinase [Includes: Choline kinase beta

# Metabolic_Enzyme_3_Synonyms:
CK; Ethanolamine kinase; EK]

# Metabolic_Enzyme_3_Gene_Name:
CHKB

# Metabolic_Enzyme_3_Protein_Sequence:
>Choline/ethanolamine kinase Includes: Choline kinase beta
MAAEATAVAGSGAVGGCLAKDGLQQSKCPDTTPKRRRASSLSRDAERRAYQWCREYLGGA
WRRVQPEELRVYPVSGGLSNLLFRCSLPDHLPSVGEEPREVLLRLYGAILQGVDSLVLES
VMFAILAERSLGPQLYGVFPEGRLEQYIPSRPLKTQELREPVLSAAIATKMAQFHGMEMP
FTKEPHWLFGTMERYLKQIQDLPPTGLPEMNLLEMYSLKDEMGNLRKLLESTPSPVVFCH
NDIQEGNILLLSEPENADSLMLVDFEYSSYNYRGFDIGNHFCEWVYDYTHEEWPFYKARP
TDYPTQEQQLHFIRHYLAEAKKGETLSQEEQRKLEEDLLVEVSRYALASHFFWGLWSILQ
ASMSTIEFGYLDYAQSRFQFYFQQKGQLTSVHSSS

# Metabolic_Enzyme_3_Number_of_Residues:
395

# Metabolic_Enzyme_3_Molecular_Weight:
45272

# Metabolic_Enzyme_3_Theoretical_pI:
5.20

# Metabolic_Enzyme_3_GO_Classification:
Not Available

# Metabolic_Enzyme_3_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_3_Specific_Function:
ATP + choline = ADP + O-phosphocholine

# Metabolic_Enzyme_3_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_3_Reaction:
ATP + ethanolamine = ADP + O-phosphoethanolamine

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01633:Choline_kinase

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.7.1.32;EC 2.7.1.82

# Metabolic_Enzyme_3_GenBank_ID_Protein:
5509940

# Metabolic_Enzyme_3_SwissProt_ID:
CHKB_HUMAN (Q9Y259)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
CHKB

# Metabolic_Enzyme_3_Geneatlas_id:
CHKB

# Metabolic_Enzyme_3_hgnc_id:
HGNC:1938

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>1188 bp
ATGGCGGCCGAGGCGACAGCTGTGGCCGGAAGCGGGGCTGTTGGCGGCTGCCTGGCCAAA
GACGGCTTGCAGCAGTCTAAGTGCCCGGACACTACCCCAAAACGGCGGCGCGCCTCGTCG
CTGTCGCGTGACGCCGAGCGCCGAGCCTACCAATGGTGCCGGGAGTACTTGGGCGGGGCC
TGGCGCCGAGTGCAGCCCGAGGAGCTGAGGGTTTACCCCGTGAGCGGAGGCCTCAGCAAC
CTGCTCTTCCGCTGCTCGCTCCCGGACCACCTGCCCAGCGTTGGCGAGGAGCCCCGGGAG
GTGCTTCTGCGGCTGTACGGAGCCATCTTGCAGGGCGTGGACTCCCTGGTGCTAGAAAGC
GTGATGTTCGCCATACTTGCGGAGCGGTCGCTGGGGCCCCAGCTGTACGGAGTCTTCCCA
GAGGGCCGGCTGGAACAGTACATCCCAAGTCGGCCATTGAAAACTCAAGAGCTTCGAGAG
CCAGTGTTGTCAGCAGCCATTGCCACGAAGATGGCGCAATTTCATGGCATGGAGATGCCT
TTCACCAAGGAGCCCCACTGGCTGTTTGGGACCATGGAGCGGTACCTAAAACAGATCCAG
GACCTGCCCCCAACTGGCCTCCCTGAGATGAACCTGCTGGAGATGTACAGCCTGAAGGAT
GAGATGGGCAACCTCAGGAAGTTACTAGAGTCTACCCCATCGCCAGTCGTCTTCTGCCAC
AATGACATCCAGGAAGGGAACATCTTGCTGCTCTCAGAGCCAGAAAATGCTGACAGCCTC
ATGCTGGTGGACTTCGAGTACAGCAGTTATAACTATAGGGGCTTTGACATTGGGAACCAT
TTTTGTGAGTGGGTTTATGATTATACTCACGAGGAATGGCCTTTCTACAAAGCAAGGCCC
ACAGACTACCCCACTCAAGAACAGCAGTTGCATTTTATTCGTCATTACCTGGCAGAGGCA
AAGAAAGGTGAGACCCTCTCCCAAGAGGAGCAGAGAAAACTGGAAGAAGATTTGCTGGTA
GAAGTCAGTCGGTATGCTCTGGCATCCCATTTCTTCTGGGGTCTGTGGTCCATCCTCCAG
GCATCCATGTCCACCATAGAATTTGGTTACTTGGACTATGCCCAGTCTCGGTTCCAGTTC
TACTTCCAGCAGAAGGGGCAGCTGACCAGTGTCCACTCCTCATCCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
AB029885

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_3_Locus:
22q13.33

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
10918069

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5311

# Metabolic_Enzyme_4_Name:
Phospholipase D1

# Metabolic_Enzyme_4_Synonyms:
PLD 1; Choline phosphatase 1; Phosphatidylcholine-hydrolyzing phospholipase D1; hPLD1

# Metabolic_Enzyme_4_Gene_Name:
PLD1

# Metabolic_Enzyme_4_Protein_Sequence:
>Phospholipase D1
MSLKNEPRVNTSALQKIAADMSNIIENLDTRELHFEGEEVDYDVSPSDPKIQEVYIPFSA
IYNTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTTRVPSINLYTIELTHGEFKWQVKRKF
KHFQEFHRELLKYKAFIRIPIPTRRHTFRRQNVREEPREMPSLPRSSENMIREEQFLGRR
KQLEDYLTKILKMPMYRNYHATTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNC
CGQGRACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRID
NLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENALAKWYVNAKG
YFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLY
KEVELALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGI
DLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLKDKNEPVQNLPIQKS
IDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGL
KPHFKLFHPSSESEQGLTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQL
DKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLL
PKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIE
NQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQ
AIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLL
IADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCF
RVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFI
NKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLLPSVGTKEAIVPMEVWT

# Metabolic_Enzyme_4_Number_of_Residues:
1074

# Metabolic_Enzyme_4_Molecular_Weight:
124186

# Metabolic_Enzyme_4_Theoretical_pI:
9.07

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic

# Metabolic_Enzyme_4_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_4_Reaction:
A phosphatidylcholine + H2O = choline + a phosphatidate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00169:PH;
PF00614:PLDc;
PF00787:PX

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.1.4.4

# Metabolic_Enzyme_4_GenBank_ID_Protein:
1185463

# Metabolic_Enzyme_4_SwissProt_ID:
PLD1_HUMAN (Q13393)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
PLD1

# Metabolic_Enzyme_4_Geneatlas_id:
PLD1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:9067

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasm; perinuclear region. Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity). Endosome; late endosome (By similarity)

# Metabolic_Enzyme_4_Gene_Sequence:
>3225 bp
ATGTCACTGAAAAACGAGCCACGGGTAAATACCTCTGCACTGCAGAAAATTGCTGCTGAC
ATGAGTAATATCATAGAAAATCTGGACACGCGGGAACTCCACTTTGAGGGAGAGGAGGTA
GACTACGACGTGTCTCCCAGCGATCCCAAGATACAAGAAGTGTATATCCCTTTCTCTGCT
ATTTATAACACTCAAGGATTTAAGGAGCCTAATATACAGACGTATCTCTCCGGCTGTCCA
ATAAAAGCACAAGTTCTGGAAGTGGAACGCTTCACATCTACAACAAGGGTACCAAGTATT
AATCTTTACACTATTGAATTAACACATGGGGAATTTAAATGGCAAGTTAAGAGGAAATTC
AAGCATTTTCAAGAATTTCACAGAGAGCTGCTCAAGTACAAAGCCTTTATCCGCATCCCC
ATTCCCACTAGAAGACACACGTTTAGGAGGCAAAACGTCAGAGAGGAGCCTCGAGAGATG
CCCAGTTTGCCCCGTTCATCTGAAAACATGATAAGAGAAGAACAATTCCTTGGTAGAAGA
AAACAACTGGAAGATTACTTGACAAAGATACTAAAAATGCCCATGTATAGAAACTATCAT
GCCACAACAGAGTTTCTTGATATAAGCCAGCTGTCTTTCATCCATGATTTGGGACCAAAG
GGCATAGAAGGTATGATAATGAAAAGATCTGGAGGACACAGAATACCAGGCTTGAATTGC
TGTGGTCAGGGAAGAGCCTGCTACAGATGGTCAAAAAGATGGTTAATAGTGAAAGATTCC
TTTTTATTGTATATGAAACCAGACAGCGGTGCCATTGCCTTCGTCCTGCTGGTAGACAAA
GAATTCAAAATTAAGGTGGGGAAGAAGGAGACAGAAACGAAATATGGAATCCGAATTGAT
AATCTTTCAAGGACACTTATTTTAAAATGCAACAGCTATAGACATGCTCGGTGGTGGGGA
GGGGCTATAGAAGAATTCATCCAGAAACATGGCACCAACTTTCTCAAAGATCATCGATTT
GGGTCATATGCTGCTATCCAAGAGAATGCTTTAGCTAAATGGTATGTTAATGCCAAAGGA
TATTTTGAAGATGTGGCAAATGCAATGGAAGAGGCAAATGAAGAGATTTTTATCACAGAC
TGGTGGCTGAGTCCAGAAATCTTCCTGAAACGCCCAGTGGTTGAGGGAAATCGTTGGAGG
TTGGACTGCATTCTTAAACGAAAAGCACAACAAGGAGTGAGGATCTTCATAATGCTCTAC
AAAGAGGTGGAACTCGCTCTTGGCATCAATAGTGAATACACCAAGAGGACTTTGATGCGT
CTACATCCCAACATAAAGGTGATGAGACACCCGGATCATGTGTCATCCACCGTCTATTTG
TGGGCTCACCATGAGAAGCTTGTCATCATTGACCAATCGGTGGCCTTTGTGGGAGGGATT
GACCTGGCCTATGGAAGGTGGGACGACAATGAGCACAGACTCACAGACGTGGGCAGTGTG
AAGCGGGTCACTTCAGGACCGTCTCTGGGTTCCCTCCCACCTGCCGCAATGGAGTCTATG
GAATCCTTAAGACTCAAAGATAAAAATGAGCCTGTTCAAAACCTACCCATCCAGAAGAGT
ATTGATGATGTGGATTCAAAACTGAAAGGAATAGGAAAGCCAAGAAAGTTCTCCAAATTT
AGTCTCTACAAGCAGCTCCACAGGCACCACCTGCACGACGCAGATAGCATCAGCAGCATT
GACAGCACCTCCAGTTATTTTAATCACTATAGAAGTCATCACAATTTAATCCATGGTTTA
AAACCCCACTTCAAACTCTTTCACCCGTCCAGTGAGTCTGAGCAAGGACTCACTAGACCT
CATGCTGATACCGGGTCCATCCGTAGTTTACAGACAGGTGTGGGAGAGCTGCATGGGGAA
ACCAGATTCTGGCATGGAAAGGACTACTGCAATTTCGTCTTCAAAGACTGGGTTCAACTT
GATAAACCTTTTGCTGATTTCATTGACAGGTACTCCACGCCCCGGATGCCCTGGCATGAC
ATTGCCTCTGCAGTCCACGGGAAGGCGGCTCGTGATGTGGCACGTCACTTCATCCAGCGC
TGGAACTTCACAAAAATTATGAAATCAAAATATCGGTCCCTTTCTTATCCTTTTCTGCTT
CCAAAGTCTCAAACAACAGCCCATGAGTTGAGATATCAAGTGCCTGGGTCTGTCCATGCT
AACGTACAGTTGCTCCGCTCTGCTGCTGATTGGTCTGCTGGTATAAAGTACCATGAAGAG
TCCATCCACGCCGCTTACGTCCATGTGATAGAGAACAGCAGGCACTATATCTATATCGAA
AACCAGTTTTTCATAAGCTGTGCTGATGACAAAGTTGTGTTCAACAAGATAGGCGATGCC
ATTGCCCAGAGGATCCTGAAAGCTCACAGGGAAAACCAGAAATACCGGGTATATGTCGTG
ATACCACTTCTGCCAGGGTTCGAAGGAGACATTTCAACCGGCGGAGGAAATGCTCTACAG
GCAATCATGCACTTCAACTACAGAACCATGTGCAGAGGAGAAAATTCCATCCTTGGACAG
TTAAAAGCAGAGCTTGGTAATCAGTGGATAAATTACATATCATTCTGTGGTCTTAGAACA
CATGCAGAGCTCGAAGGAAACCTAGTAACTGAGCTTATCTATGTCCACAGCAAGTTGTTA
ATTGCTGATGATAACACTGTTATTATTGGCTCTGCCAACATAAATGACCGCAGCATGCTG
GGAAAGCGTGACAGTGAAATGGCTGTCATTGTGCAAGATACAGAGACTGTTCCTTCAGTA
ATGGATGGAAAAGAGTACCAAGCTGGCCGGTTTGCCCGAGGACTTCGGCTACAGTGCTTT
AGGGTTGTCCTTGGCTATCTTGATGACCCAAGTGAGGACATTCAGGATCCAGTGAGTGAC
AAATTCTTCAAGGAGGTGTGGGTTTCAACAGCAGCTCGAAATGCTACAATTTATGACAAG
GTTTTCCGGTGCCTTCCCAATGATGAAGTACACAATTTAATTCAGCTGAGAGACTTTATA
AACAAGCCCGTATTAGCTAAGGAAGATCCCATTCGAGCTGAGGAGGAACTGAAGAAGATC
CGTGGATTTTTGGTGCAATTCCCCTTTTATTTCTTGTCTGAAGAAAGCCTACTGCCTTCT
GTTGGGACCAAAGAGGCCATAGTGCCCATGGAGGTTTGGACTTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
U38545

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_4_Locus:
3q26

# Metabolic_Enzyme_4_SNPs:
rs9819927; rs2290480; rs9827333; rs2287579; rs9881788; rs6766336; rs2124147; rs9821754; rs9822322; rs1473377; rs1869648; rs1563262; rs2168205; rs754051; rs1454903; rs2178533; rs4894497; rs4131285; rs6809327; rs4894755; rs10936697; rs4256166; rs9838510; rs6445019; rs6790634; rs7610093; rs2422375; rs9866473; rs6445020; rs7635025; rs1869647; rs4894499; rs1902139; rs6791758; rs7647840; rs2305548; rs9290424; rs7631698; rs6445024; rs6781814; rs7643183; rs7634685; rs1882256; rs6798723; rs7616441; rs7620136; rs6445009; rs3774034; rs6764162; rs7611425; rs1563261; rs12632647; rs9290426; rs3774033; rs1921345; rs4894760; rs1882257; rs6445018; rs3774041; rs4582082; rs6809647; rs4131284; rs6763711; rs9290428; rs6807121; rs9882641; rs4894504; rs2061064; rs6781809; rs6445023; rs6445017; rs4894495; rs9835318; rs9290423; rs9810450; rs4894742; rs7616376; rs6445010; rs2901726; rs11718550; rs9859424; rs11714365; rs9846460; rs4894493; rs3774045; rs4894740; rs6769286; rs6445015; rs4894728; rs7618276; rs1392208; rs4894754; rs10936699; rs9828579; rs11712503; rs4243417; rs4894743; rs360408; rs2290479; rs1378242; rs6809419; rs9836954; rs6794587; rs4894492; rs9863761; rs6771343; rs2276794; rs2422377; rs1921344; rs9831491; rs9836712; rs6761990; rs7626797; rs12491008; rs9985447; rs7652359; rs4894490; rs4894707; rs6805911; rs10755128; rs7624560; rs9850783; rs6445011; rs7632685; rs7624044; rs7620874; rs7616430; rs7619079; rs7620815; rs10513698; rs6794795; rs16856569; rs6788652; rs7614707; rs7618750; rs3774039; rs7616361; rs4131283; rs7622276; rs9290432; rs6445013; rs3774036; rs6806023; rs10936698; rs6797824; rs6793193; rs6806989; rs7612421; rs6805425; rs7649974; rs3774038; rs6781853; rs9290430; rs1076504; rs360399; rs2422376; rs2276793; rs4894753; rs6445016; rs2305547; rs6794454; rs7617044; rs11929621; rs4894750; rs9830433; rs9869963; rs7616760; rs9820542; rs9845959; rs6773632; rs9858001; rs4493457; rs373999; rs7632580; rs7628731; rs9290434; rs9811588; rs9844363; rs9869289; rs9817899; rs4894747; rs9824608; rs6772146; rs9842562; rs35765488; rs6785259; rs6767012; rs9290422; rs13091852; rs16856578; rs9860213; rs17518961; rs416158; rs11917857; rs6764285; rs6774359; rs16856586; rs9823244; rs6445012; rs6782508; rs9832053; rs11720952; rs13323527; rs7632491; rs9862429; rs9818692; rs9818399; rs3774037; rs3774040; rs9855905; rs9818812; rs9869368; rs9818540; rs9880548; rs4894503; rs1454902; rs11916755; rs4894496; rs6783321; rs6773529; rs9829394; rs12635653; rs7433336; rs7638344; rs749481; rs9826766; rs9870809; rs9881676; rs1392209; rs9841075; rs2287577; rs16856581; rs6763933; rs9815257; rs4894494; rs7609750; rs6782049; rs7631356; rs11712311; rs7652569; rs7631869; rs2002006; rs360407; rs1392207; rs7625755; rs9714380; rs7638141; rs7631451; rs9917830; rs9832431; rs9290425; rs4894491; rs13320926; rs9879513; rs4894746; rs7355830; rs4894715; rs9871902; rs6781556; rs4261904; rs6804535; rs13327509; rs35127978; rs9821947; rs34195468; rs1054253; rs9822242; rs36012544; rs35101789; rs35670538; rs13068935; rs35483608; rs34637085; rs28759283; rs2544153; rs34136570; rs360405; rs9871708; rs10613561; rs5854444; rs34942380; rs2045170; rs13321633; rs11378587; rs9860038; rs9880430; rs4568171; rs9838989; rs13323858; rs35006593; rs12107890; rs9810871; rs35851997; rs4600841; rs9883453; rs3961987; rs10663017; rs9852475; rs9847979; rs6770239; rs9837034; rs4894749; rs11360799; rs6791958; rs34774903; rs35874975; rs41273589; rs41273593; rs6786358; rs34772565; rs34781513; rs9870386; rs7649966; rs11278598; rs11425932; rs6798359; rs9881170; rs3836455; rs10575495; rs9812524; rs13062967; rs35255380; rs4616674; rs7426452; rs11372398; rs9851279; rs13317506; rs7652423; rs9864065; rs9858157; rs34475209; rs35659465; rs10704846; rs9828238; rs11929048; rs41273595; rs9858003; rs7429181; rs34047635; rs28642384; rs5854448; rs9863552; rs36230395; rs1823923; rs9863833; rs705025; rs35365001; rs13084373; rs10621695; rs10552176; rs10702797; rs4613482; rs34590693; rs1499849; rs9826758; rs5854439; rs7647033; rs9839428; rs10600843; rs9840146; rs36106956; rs35702864; rs34750843; rs3774042; rs6783520; rs10710862; rs11456805; rs35333974; rs5854445; rs9859130; rs2604103; rs13327893; rs11393886; rs9821786; rs6792460; rs35608149; rs3050412; rs9832151; rs11338168; rs193333; rs10704146; rs9876786; rs35107980; rs35881246; rs11360798; rs731044; rs34366683; rs7432859; rs36082494; rs6796730; rs36068935; rs34786482; rs28711733; rs10702650; rs34463479; rs34861885; rs10594654; rs3214830; rs4449349; rs10663360; rs13088019; rs12107937; rs12638735; rs6792564; rs12631679; rs2544151; rs35406267; rs10619884; rs35965110; rs41273587; rs34045644; rs35032653; rs11319073; rs9851422; rs10625716; rs11359377; rs7630703; rs34976174; rs35452974; rs12633024; rs34667914; rs6803986; rs10684599; rs10621070; rs34526007; rs7632331; rs9814325; rs35601747; rs34921372; rs34815441; rs9871544; rs34904148; rs9871396; rs13068940; rs35759055; rs6781880; rs35888555; rs9290429; rs9864124; rs5854440; rs9851447; rs34234073; rs6788739; rs11391361; rs6774916; rs13079449; rs10620004; rs5854443; rs28375171; rs11372810; rs11299225; rs433586; rs2909557; rs35118621; rs3050415; rs11268323; rs9837314; rs6762792; rs754050; rs13326409; rs9832303; rs33925478; rs11378586; rs1378243; rs12107844; rs9878033; rs10684636; rs13318350; rs2544152; rs9825980; rs3774044; rs5854447; rs34320069; rs10222579; rs9810537; rs35334642; rs36096949; rs7612499; rs10576803; rs34006230; rs28668937; rs35539240; rs7624132; rs7610063; rs12634083; rs6804852; rs360406; rs11310595; rs11401263; rs35085404; rs35848779; rs10704304; rs5854442; rs3821745; rs4894730; rs11706109; rs35055974; rs10621127; rs10703192; rs28407244; rs7429182; rs3050440; rs9858995; rs35382479; rs2287578; rs731043; rs11416324; rs4438685; rs28749915; rs4488867; rs11346342; rs11375259; rs4349528; rs9826593; rs9942046; rs11456818; rs13060859; rs7645352; rs6795501; rs9829798; rs7632869; rs10663361; rs13068911; rs387964; rs34919896; rs9882439; rs11342343; rs9837366; rs9858838; rs1392210; rs34198532; rs4894748; rs35606158; rs35396258; rs11397647; rs35724069; rs34772058; rs34883446; rs10621200; rs1106288; rs9868868; rs28552643; rs11321947; rs9851549; rs9826698; rs35175182; rs6785257; rs34340739; rs10704153; rs28663429; rs41273591; rs34385980; rs11375502; rs7642800; rs12106843; rs35731319; rs9830147; rs9871438; rs34629638; rs35213067; rs4293729; rs4635737; rs35959131; rs11430413; rs11399852; rs11359957; rs10049336; rs7648386; rs189827; rs11420673; rs5854446; rs7355994; rs7624820; rs13318483; rs10619883; rs35982384; rs12107445; rs9824139; rs34132902; rs35961431; rs7644780; rs10561828; rs34441571; rs6768605; rs3050403; rs5854438; rs10614037; rs5854441; rs10936694; rs12631941; rs13063848; rs13326387; rs16856509; rs16856522; rs181715; rs2604101; rs360400; rs360401; rs360402; rs360404; rs4378993; rs4894475; rs4894476; rs6775402; rs6780561; rs6800474; rs6801138; rs6803271; rs6804870; rs7635962; rs83615; rs83616; rs9815479; rs9820941; rs9871488; rs9871646; rs9872171; rs9872527; rs9876839

# Metabolic_Enzyme_4_General_References:
8530346; 9013646; 9761774; 9582313

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5480

# Metabolic_Enzyme_5_Name:
4-aminobutyrate aminotransferase, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
(S-3-amino-2-methylpropionate transaminase; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA aminotransferase; GABA-AT; GABA-T; L-AIBAT

# Metabolic_Enzyme_5_Gene_Name:
ABAT

# Metabolic_Enzyme_5_Protein_Sequence:
>4aminobutyrate aminotransferase, mitochondrial precursor
MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMK
QLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQ
NASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYR
SKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPS
FDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGG
DNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMM
TGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLL
DLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVF
RDHHAHLFLNIFSDILADFK

# Metabolic_Enzyme_5_Number_of_Residues:
500

# Metabolic_Enzyme_5_Molecular_Weight:
56440

# Metabolic_Enzyme_5_Theoretical_pI:
8.04

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  4-aminobutyrate transaminase activity
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid derivative metabolism
Process:  gamma-aminobutyric acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine

# Metabolic_Enzyme_5_Pathway:
map00280  Valine, leucine and isoleucine degradation;
GENES       ECO: b2662(gabT);
            ECJ: JW2637(gabT);
            ECE: Z3960(gabT);
            ECS: ECs3523;
            ECC: c3210(gabT);
            STY: STY2912(gabT);
            STT: t2687(gabT);
            SPT: SPA2649(gabT);
            SEC: SC2724(gabT);
            STM: STM2792(gabT);
            YPE: YPO2844(goaG);
            YPK: y1390(goaG);
            YPM: YP2711(goaG);
            YPS: YPTB2810(goaG);
            SFL: SF2689(gabT);
            SFX: S2874(gabT);
            ECA: ECA2053(gabT);
            PLU: plu2347(goaG);
            VPA: VP1771;
            PAE: PA0266(gabT);
            PPU: PP0214(gabT);
            PST: PSPTO0301(gabT-2);
            PSB: Psyr_0090;
            ACI: ACIAD3446(gabT);
            SON: SO1276(gabT);
            CVI: CV3926(goaG);
            RSO: RSc0029(goaG);
            BMA: BMAA1480(gabT);
            BPS: BPSS0281(gabT);
            BPE: BP2298;
            BPA: BPP2431;
            BBR: BB1880;
            MLO: mlr5521;
            SME: SMb21186(gabT);
            RPA: RPA2323(goaT);
            SIL: SPOA0274(gabT);
            BAN: BA0325(gabT);
            BAR: GBAA0325(gabT);
            BAA: BA_0895;
            BAT: BAS0310;
            BCA: BCE0354(gabT);
            BCZ: BCZK0297(gabT)

# Metabolic_Enzyme_5_Reaction:
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00202:Aminotran_3

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.6.1.19;EC 2.6.1.22

# Metabolic_Enzyme_5_GenBank_ID_Protein:
602705

# Metabolic_Enzyme_5_SwissProt_ID:
GABT_HUMAN (P80404)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ABAT

# Metabolic_Enzyme_5_Geneatlas_id:
ABAT

# Metabolic_Enzyme_5_hgnc_id:
HGNC:23

# Metabolic_Enzyme_5_PDB_ID:
1OHY

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_5_Gene_Sequence:
>1503 bp
ATGGCCTCCATGTTGCTCGCCCAGCGGCTGGCCTGCAGCTTCCAGCACACGTACCGCCTG
CTGGTGCCTGGATCCAGACACATTAGTCAAGCTGCAGCCAAAGTCGACGTTGAATTTGAT
TATGATGGGCCTCTGATGAAGACGGAAGTCCCAGGGCCTAGATCTCAGGAGTTAATGAAA
CAGCTGAATATAATTCAGAATGCAGAGGCTGTGCATTTTTTCTGCAATTACGAAGAGAGC
CGAGGCAATTACCTGGTTGATGTGGACGGCAACCGAATGCTGGATCTTTATTCCCAGATC
TCCTCTGTTCCCATAGGTTACAGCGACCCGGCCCTCGTGAAACTCATCCAACAGCCACAA
AATGCGAGCATGTTTGTCAACAGACCCGCCCTCGAAATCCTGCCTCCGGAGAACTTTGTG
GAGAAGCTCCGGCAGTCCTTGCTCTCGGTGGCTCCCAAAGGGATGTCCCAGCTCATCACC
ATGGCCTGCGGCTCCTGCTCCAATGAAAACGCCTTAAAGACCATCTTCATGTGGTACCGG
AGCAAGGAAAGAGGGCAGAGGGGATTCTCCAAAGAGGAGCTGGAGACGTGCATGATTAAC
CAGGCCCCCTGGTGCCCCGACTACAGCATCCTCTCCTTCATGGGTTCCTTCCATGGGAGG
ACCATGGGTTGCTTAGCGACCACGCACTCTAAAGCCATTCACAAGATCGATATCCCTTCC
TTTGACTGGCCCATCGCACCGTTCCCACGGCTGAAATACCCTCTGGAAGAGTTTGTGAAA
GAGAACCAACAGGAAGAGGCCGGCTGTCTGGAAGAGGTTGAGGATCTGATTGTGAAATAT
CGAAAAAAGAAGAAGACGGTGGCCGGGATCATCGTGGAGCCCATCCAGTCCGAGGGTGGA
GACAACCATGCATCCGATGACTTCTTTCGGAAGCTGAGAGACATCGCCAGGAAGCACTGC
TGCGCCTTCTTGGTGGACGAGGTCCAGACCGGAGGAGGCTGCACGGGCAAGTTCTGGGCC
CATGAGCACTGGGGCCTGGATGACCCAGCAGACGTGATGACCTTCAGCAAGAAGATGATG
ACTGGGGGCTTCTTCCTCAAGGAGGAGTTCAGGCCTAATGCTCCCTACCGGATCTTCAAC
ACGTGGCTGGGGGACCCGTCCAAGAACCTGTTGCTGGCTGAGGTCATCAACATCATCAAG
CGGGAGGACCTGCTAAATAATGCAGCCCATGCCGGGAAGGCCCTGCTCACAGGACTGCTG
GACCTCCAGGCCCGGTACCCCCAGTTCATCAGCAGGGTGAGAGGACGAGGCACCTTTTGC
TCCTTCGATACTCCCGATGATTCCATACGGAATAAGCTCATTTTAATTGCCAGAAACAAA
GGTGTGGTGTTGGGTGGCTGTGGTGACAAATCCATTCGTTTCCGTCCCACGCTGGTGTTC
AGGGATCACCACGCTCACCTGTTCCTCAATATTTTCAGTGACATCTTAGCAGACTTCAAG
TAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
L32961

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_5_Locus:
16p13.2

# Metabolic_Enzyme_5_SNPs:
rs1731017; rs1641022; rs28687443; rs1731062; rs1006636; rs747329; rs1730951; rs1273350; rs1273394; rs1730948; rs4454975; rs3743801; rs1730946; rs6497519; rs1730941; rs2313427; rs1641113; rs1273364; rs4984996; rs1641107; rs747330; rs1273396; rs11075408; rs6497548; rs1730945; rs6497583; rs1295741; rs1641112; rs1273373; rs1640989; rs1273357; rs4985113; rs8062395; rs1730952; rs7205816; rs1641032; rs3108684; rs1730954; rs1273393; rs7199025; rs4985114; rs4985036; rs1730958; rs9935902; rs1641110; rs6497327; rs4985000; rs1273351; rs8055836; rs1641108; rs1344476; rs1730938; rs1730953; rs1730943; rs1641111; rs1730937; rs4984997; rs17566580; rs737695; rs3095512; rs1289964; rs1273360; rs1273397; rs9456; rs1273381; rs1273359; rs1731071; rs1273353; rs1640997; rs3743798; rs1273355; rs9935408; rs6498753; rs17674530; rs1273356; rs12933164; rs1273376; rs1730956; rs1273361; rs1273390; rs12447371; rs12596289; rs1731083; rs1641031; rs12445987; rs12597124; rs4445904; rs11648372; rs1640995; rs1730961; rs1273395; rs11645254; rs9935422; rs1295740; rs11647162; rs4984998; rs11646372; rs1273366; rs1640979; rs7499026; rs2313548; rs6498755; rs1640980; rs3095514; rs1273372; rs1273363; rs6497565; rs11074405; rs1273358; rs1731061; rs1273382; rs1730955; rs1273352; rs1273367; rs7499025; rs1640971; rs7201586; rs1730949; rs1640974; rs1641106; rs8052707; rs1612155; rs1273391; rs12596654; rs12448579; rs1641109; rs1807439; rs8056063; rs1273349; rs1731081; rs1731082; rs9923953; rs8059639; rs3095516; rs1730944; rs11642785; rs8061555; rs1061842; rs1641105; rs8056550; rs12149040; rs1731078; rs7194430; rs1730959; rs1420082; rs12448693; rs12597484; rs737696; rs1273380; rs1273370; rs8058062; rs1640973; rs1731069; rs1730947; rs1731085; rs1731079; rs2270289; rs3095515; rs1640978; rs1640981; rs1730962; rs1640996; rs9939980; rs1123891; rs8054014; rs1273369; rs1730957; rs9928478; rs8046210; rs12921061; rs2270288; rs7501036; rs11648678; rs1273383; rs1273362; rs11643667; rs1730939; rs1881828; rs1640988; rs2313596; rs12444390; rs1731080; rs17651562; rs16964282; rs9935013; rs7193087; rs11866675; rs8275; rs10261; rs12445958; rs1731070; rs737694; rs8048045; rs7192026; rs7197787; rs8050233; rs1640994; rs3095513; rs8049263; rs12447028; rs11643578; rs3095510; rs1641021; rs9674265; rs8057362; rs1273427; rs1641024; rs1273398; rs1273422; rs1273424; rs2091634; rs7196462; rs1273430; rs1640998; rs8053509; rs8049072; rs9673595; rs12708689; rs4985035; rs1641003; rs1641019; rs6497960; rs7197673; rs1273425; rs12447235; rs1273429; rs8055880; rs1641025; rs1273433; rs3815507; rs1079350; rs4482281; rs11863437; rs1273423; rs1731039; rs1731019; rs1640999; rs1641007; rs12446980; rs12925086; rs13337024; rs13336159; rs9937726; rs933481; rs1273431; rs1641014; rs12446169; rs8060255; rs1641002; rs1078509; rs1273417; rs1641027; rs1641016; rs1731027; rs12448959; rs6497959; rs1273428; rs1079348; rs11862060; rs11074631; rs2103340; rs753071; rs1731026; rs1731072; rs1299926; rs1273420; rs8055737; rs12448823; rs1079349; rs1731086; rs7203297; rs1273406; rs3815508; rs1641001; rs8061093; rs9937937; rs9302405; rs11640989; rs8056083; rs11866199; rs1273426; rs9924807; rs1273419; rs1273402; rs1641030; rs7206830; rs1273421; rs8053030; rs12596790; rs8046201; rs11865147; rs1731087; rs1731073; rs13338443; rs1273415; rs12918897; rs1641010; rs8055927; rs11074534; rs13335330; rs1731030; rs1641015; rs9929124; rs10775278; rs1641023; rs1420084; rs9673228; rs7193333; rs1990574; rs1894861; rs1965648; rs1078511; rs1731020; rs1641008; rs1731034; rs1273407; rs1612383; rs11647952; rs2464048; rs1731018; rs9673371; rs7193305; rs1641011; rs1273416; rs1273400; rs11074713; rs1641029; rs9673409; rs1465319; rs1965649; rs1420085; rs10775279; rs11860865; rs12445730; rs11641035; rs1273408; rs7200886; rs1630164; rs13332999; rs1731029; rs1273401; rs1616856; rs1273412; rs1273418; rs12445609; rs11074695; rs8057162; rs13336186; rs11074533; rs1075853; rs1273413; rs11074712; rs3217123; rs9673401; rs1641026; rs12922831; rs12445687; rs13332215; rs12102631; rs12598074; rs12444233; rs1731036; rs1641006; rs12930556; rs12325344; rs933482; rs13339338; rs1613314; rs1965647; rs8061716; rs4989413; rs2302608; rs1641013; rs8048375; rs1617601; rs12448478; rs1273410; rs1465318; rs8060512; rs1641017; rs12149331; rs13331042; rs8047293; rs4984999; rs11646271; rs10852271; rs9925620; rs10775277; rs8060323; rs9931017; rs1420083; rs7203550; rs1641104; rs1139523; rs1139520; rs35780038; rs41311264; rs1139522; rs1062593; rs1139525; rs34813662; rs1042495; rs1139521; rs1139519; rs8059762; rs35850996; rs1273386; rs1640972; rs34187437; rs12597184; rs28415910; rs7195521; rs36138946; rs28587720; rs1640985; rs12149146; rs1731059; rs34441266; rs28403171; rs9939846; rs1640993; rs1273377; rs34595424; rs35454761; rs1273378; rs7195079; rs35916063; rs1640987; rs1273371; rs9928667; rs4296259; rs13334372; rs28382303; rs35255805; rs33951087; rs1630895; rs1731084; rs1273388; rs16964376; rs34014796; rs35351214; rs1730950; rs7184890; rs34724138; rs1640977; rs4442807; rs1731064; rs17651173; rs7204053; rs1273374; rs1730960; rs2178371; rs1640975; rs3095511; rs2160182; rs13337410; rs35163930; rs28692588; rs8056066; rs34165726; rs1731075; rs35012807; rs35638621; rs1640986; rs5815494; rs28602865; rs1273368; rs1640992; rs28622536; rs1731058; rs12149145; rs7190843; rs28714127; rs35832558; rs8056594; rs1986108; rs33928355; rs1640984; rs34006471; rs8060892; rs28742255; rs9746220; rs12926736; rs35163795; rs1273365; rs34531177; rs3065947; rs1640991; rs34595884; rs34089650; rs35176944; rs34736230; rs2313428; rs10163233; rs1731057; rs8049522; rs730750; rs34452392; rs9941133; rs34403235; rs34698480; rs1640970; rs34686381; rs8056020; rs7196194; rs35069718; rs28581915; rs28589960; rs8046394; rs34733640; rs1640983; rs12446703; rs13337518; rs28609006; rs1730942; rs1731076; rs7187850; rs35596444; rs8046003; rs28864687; rs1640990; rs12325121; rs8046571; rs9931939; rs8044285; rs7203755; rs41312250; rs8062725; rs28618356; rs13338663; rs7195524; rs28650912; rs35853974; rs34216922; rs13333072; rs10163342; rs12925473; rs1273379; rs7499024; rs1273387; rs5815492; rs13338551; rs7498949; rs34887951; rs28397834; rs7196287; rs28568507; rs2052235; rs34327953; rs34516341; rs28679855; rs35724649; rs11861413; rs7206673; rs2160181; rs1627524; rs35141742; rs1731077; rs1641114; rs13336886; rs12149463; rs35336676; rs34655579; rs9934284; rs35896679; rs1730940; rs8046260; rs1273375; rs28430948; rs3069301; rs35773832; rs28483683; rs5815493; rs11642744; rs8052663; rs1273389; rs12445001; rs35804023; rs35621836; rs1273392; rs3108683; rs34943374; rs1640982; rs35771183; rs4985115; rs1640976; rs1731088; rs12932819; rs35772192; rs34403809; rs34264472; rs9931477; rs8063475; rs1731024; rs11862275; rs36095894; rs753070; rs1273403; rs1298679; rs1630161; rs34085775; rs28785577; rs7192987; rs33948976; rs13337697; rs3069345; rs12924611; rs1731068; rs1465317; rs13339388; rs28557212; rs34198010; rs6497761; rs7188839; rs13337020; rs12921235; rs28669991; rs12598010; rs1078510; rs1320812; rs35617486; rs13338915; rs12445356; rs9674283; rs36191361; rs1273404; rs11647647; rs34543657; rs7198302; rs12924829; rs34544015; rs36181426; rs1627098; rs1731038; rs9923086; rs1273411; rs36055711; rs10153069; rs1641004; rs1731033; rs1657081; rs35468187; rs13337062; rs7200508; rs7185579; rs35255659; rs11649570; rs34994165; rs35503372; rs12598506; rs1641018; rs1731037; rs34598069; rs34415556; rs41307917; rs11648982; rs34761392; rs1273405; rs1548863; rs1641000; rs34630251; rs2464049; rs28568366; rs12930438; rs7205552; rs1299925; rs9941328; rs28759346; rs34495251; rs1641012; rs34900184; rs1629364; rs11862270; rs9936820; rs9926653; rs34177196; rs41312254; rs7200724; rs9932833; rs35002036; rs12935717; rs28852097; rs1273409; rs35359682; rs753072; rs10852270; rs28427346; rs35691630; rs11640314; rs10775276; rs1731025; rs28495577; rs34651404; rs34982194; rs35248639; rs36034133; rs1078508; rs12149630; rs35745596; rs9926200; rs36000891; rs7187363; rs8060324; rs7189861; rs13339115; rs35414822; rs34346487; rs35585805; rs41303767; rs35010946; rs933480; rs12447747; rs41305755; rs35405936; rs28630033; rs9941032; rs41427146; rs9922301; rs7191001; rs2313560; rs41312252; rs41311266; rs13338171; rs13339497; rs1641005; rs34408519; rs13380503; rs34755382; rs7500881; rs13335619; rs1273432; rs9936647; rs35893143; rs1273414; rs34060423; rs1623647; rs34484640; rs11647644; rs35548548; rs28398424; rs1730964; rs35258023; rs1730963; rs35440533; rs28758216; rs1060784; rs11641192; rs11860988; rs11861249; rs12103329; rs12444391; rs12444975; rs12447079; rs1273384; rs1273385; rs12929416; rs13338256; rs1345300; rs1358692; rs1641098; rs1641099; rs1641100; rs1641101; rs1865805; rs1865806; rs2160180; rs2241103; rs2312957; rs2840195; rs34611261; rs35851221; rs3743811; rs3743812; rs4985110; rs4985111; rs7188782; rs7192702; rs7200823; rs7204765; rs7205295; rs876945; rs9928906

# Metabolic_Enzyme_5_General_References:
7721088; 7851425; 10407778

# Metabolic_Enzyme_5_References:
10900239; 9351512

# Metabolic_Enzyme_6_ID:
8634

# Metabolic_Enzyme_6_Name:
Phosphoethanolamine/phosphocholine phosphatase

# Metabolic_Enzyme_6_Synonyms:
Not Available

# Metabolic_Enzyme_6_Gene_Name:
PHOSPHO1

# Metabolic_Enzyme_6_Protein_Sequence:
>Phosphoethanolamine/phosphocholine phosphatase
MSGCFPVSGLRCLSRDGRMAAQGAPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLR
ATYREGFYNEYMQRVFKYLGEQGVRPRDLSAIYEAIPLSPGMSDLLQFVAKQGACFEVIL
ISDANTFGVESSLRAAGHHSLFRRILSNPSGPDARGLLALRPFHTHSCARCPANMCKHKV
LSDYLRERAHDGVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEP
SSFRASVVPWETAADVRLHLQQVLKSC

# Metabolic_Enzyme_6_Number_of_Residues:
267

# Metabolic_Enzyme_6_Molecular_Weight:
29713

# Metabolic_Enzyme_6_Theoretical_pI:
7.78

# Metabolic_Enzyme_6_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). May be involved in the generation of inorganic phosphate for bone mineralization

# Metabolic_Enzyme_6_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_6_Reaction:
(1) O-phosphoethanolamine + H2O = ethanolamine + phosphate; (2) phosphocholine + H2O = choline + phosphate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF06888:Put_Phosphatase

# Metabolic_Enzyme_6_Signals:
Not Available

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.1.3.75

# Metabolic_Enzyme_6_GenBank_ID_Protein:
20196839

# Metabolic_Enzyme_6_SwissProt_ID:
PHOP1_HUMAN (Q8TCT1)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
PHOSPHO1

# Metabolic_Enzyme_6_Geneatlas_id:
PHOSPHO1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:16815

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_6_Gene_Sequence:
>804 bp
ATGAGTGGCTGTTTTCCAGTTTCTGGCCTCCGCTGCCTATCTAGGGACGGCAGGATGGCC
GCGCAGGGCGCGCCGCGCTTCCTCCTGACCTTCGACTTCGACGAGACTATCGTGGACGAA
AACAGCGACGATTCGATCGTGCGCGCCGCGCCGGGCCAGCGGCTCCCGGAGAGCCTGCGA
GCCACCTACCGCGAGGGCTTCTACAACGAGTACATGCAGCGCGTCTTCAAGTACCTGGGC
GAGCAGGGCGTGCGGCCGCGGGACCTGAGCGCCATCTACGAAGCCATCCCTTTGTCGCCA
GGCATGAGCGACCTGCTGCAGTTTGTGGCAAAACAGGGCGCCTGCTTCGAGGTGATTCTC
ATCTCCGATGCCAACACCTTTGGCGTGGAGAGCTCGCTGCGCGCCGCCGGCCACCACAGC
CTGTTCCGCCGCATCCTCAGCAACCCGTCGGGGCCGGATGCGCGGGGACTGCTGGCTCTG
CGGCCGTTCCACACACACAGCTGCGCGCGCTGCCCCGCCAACATGTGCAAGCACAAGGTG
CTCAGCGACTACCTGCGCGAGCGGGCCCACGACGGCGTGCACTTCGAGCGCCTCTTCTAC
GTGGGCGACGGCGCCAACGACTTCTGCCCCATGGGGCTGCTGGCGGGCGGCGACGTGGCC
TTCCCGCGCCGCGGCTACCCCATGCACCGCCTCATTCAGGAGGCCCAGAAGGCCGAGCCC
AGCTCGTTCCGCGCCAGCGTGGTGCCCTGGGAAACGGCTGCAGATGTGCGCCTCCACCTG
CAACAGGTGCTGAAGTCGTGCTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AJ457189

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_6_Locus:
17q21.32

# Metabolic_Enzyme_6_SNPs:
rs605256; rs16947328; rs617182; rs7209175; rs648980; rs35026928; rs36036830; rs34068372; rs35194032; rs8065011; rs34692121; rs34555265; rs9889994; rs850527; rs850528; rs850529; rs9807042; rs35981831; rs34982306; rs36060151; rs11654776; rs1719897; rs2233368; rs2233369; rs2233370; rs2233371; rs2233372; rs2233374; rs2293218; rs34580297; rs35031462; rs597882; rs608725; rs616338; rs623682; rs624177; rs627386; rs658979; rs671095; rs686259; rs687650; rs7219391; rs727108; rs850522

# Metabolic_Enzyme_6_General_References:
12464021

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
8708

# Metabolic_Enzyme_7_Name:
Novel protein

# Metabolic_Enzyme_7_Synonyms:
Not Available

# Metabolic_Enzyme_7_Gene_Name:
RP11-74C13.2

# Metabolic_Enzyme_7_Protein_Sequence:
>Novel protein
MAVTPREVQRLYVQVNKFALASHFFWALWALIQNQYSTIDFDFLRYAVIRFNQYFKVKPQ
ASALEMPK

# Metabolic_Enzyme_7_Number_of_Residues:
68

# Metabolic_Enzyme_7_Molecular_Weight:
8147

# Metabolic_Enzyme_7_Theoretical_pI:
10.19

# Metabolic_Enzyme_7_GO_Classification:
Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Not Available

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
Not Available

# Metabolic_Enzyme_7_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_7_Signals:
1-30

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.7.1.82

# Metabolic_Enzyme_7_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_7_SwissProt_ID:
Q5SXX4_HUMAN (Q5SXX4)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
ETNK2

# Metabolic_Enzyme_7_Geneatlas_id:
ETNK2

# Metabolic_Enzyme_7_hgnc_id:
HGNC:25575

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
Not Available

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AL592146

# Metabolic_Enzyme_7_Chromosome_Location:
Not Available

# Metabolic_Enzyme_7_Locus:
Not Available

# Metabolic_Enzyme_7_SNPs:
Not Available

# Metabolic_Enzyme_7_General_References:
Not Available

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
8866

# Metabolic_Enzyme_8_Name:
Hypothetical protein DKFZp434E1212

# Metabolic_Enzyme_8_Synonyms:
Not Available

# Metabolic_Enzyme_8_Gene_Name:
DKFZp434E1212

# Metabolic_Enzyme_8_Protein_Sequence:
>Hypothetical protein DKFZp434E1212
DNRNFLRERAGLSSAAVQTRIGNSAASRRSPAARPPVPAPPALPRGRPGTEGSTSLSAPA
VLVVAVAVVVVVVSAVAWAMANYIHVPPGSPEVPKLNVTVQDQEEHRCREGALSLLQHLR
PHWDPQEVTLQLFTDGITNKLIGCYVGNTMEDVVLVRIYGNKTELLVDRDEEVKSFRVLQ
AHGAPQLYCTFNNGLCYEFIQGEALDPKHVCNPAIFRLIARQLAKIHAIHAHNGWIPKSN
LWLKMGKYFSLIPTGFADEDINKRFLSDIPSSQILQEEMTWMKEILSNLGSPVVLCHNDL
LCKNIIYNEKQGDVQFIDYEYSGYNYLAYDIGNHFNEFAGVSDVDYSLYPDRELQSQWLR
AYLEAYKEFKGFGTEVTEKEVEILFIQVNQFALGENLNFIIGNKYCQLFSLKWLLISFGD
CGL

# Metabolic_Enzyme_8_Number_of_Residues:
423

# Metabolic_Enzyme_8_Molecular_Weight:
47495

# Metabolic_Enzyme_8_Theoretical_pI:
5.97

# Metabolic_Enzyme_8_GO_Classification:
Not Available

# Metabolic_Enzyme_8_General_Function:
Cell wall/membrane/envelope biogenesis

# Metabolic_Enzyme_8_Specific_Function:
Not Available

# Metabolic_Enzyme_8_Pathway:
Not Available

# Metabolic_Enzyme_8_Reaction:
Not Available

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF01633:Choline_kinase

# Metabolic_Enzyme_8_Signals:
Not Available

# Metabolic_Enzyme_8_Transmembrane_Regions:
56-78

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.7.1.82

# Metabolic_Enzyme_8_GenBank_ID_Protein:
52545641

# Metabolic_Enzyme_8_SwissProt_ID:
Q659C5_HUMAN (Q659C5)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
DKFZp434E1212

# Metabolic_Enzyme_8_Geneatlas_id:
DKFZp434E1212

# Metabolic_Enzyme_8_hgnc_id:
HGNC:24649

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Membrane

# Metabolic_Enzyme_8_Gene_Sequence:
>1272 bp
GACAACAGGAATTTTCTCCGAGAGCGGGCCGGGCTCAGTTCAGCTGCTGTCCAGACCCGG
ATCGGCAACAGTGCCGCCTCCAGACGTTCTCCTGCCGCTCGCCCGCCCGTCCCAGCGCCC
CCAGCCCTCCCGCGAGGGCGCCCCGGGACGGAAGGATCCACCAGTCTGTCGGCGCCCGCC
GTTCTCGTGGTCGCCGTCGCCGTCGTCGTGGTGGTAGTCTCCGCCGTCGCCTGGGCCATG
GCCAATTACATCCACGTCCCTCCCGGCTCCCCGGAGGTGCCCAAGCTGAACGTCACCGTT
CAGGATCAGGAGGAGCATCGCTGCCGGGAGGGGGCCCTGAGCCTCCTGCAACACCTGCGG
CCTCACTGGGACCCCCAGGAGGTGACCCTGCAGCTCTTCACAGATGGAATCACAAATAAA
CTTATTGGCTGTTACGTGGGAAACACCATGGAGGATGTAGTCCTGGTGAGAATTTATGGC
AATAAGACTGAGTTATTAGTCGATCGAGATGAGGAAGTAAAGAGTTTTCGAGTGTTGCAG
GCTCATGGGGCACCACAACTCTACTGTACCTTCAATAATGGACTATGCTATGAATTTATA
CAAGGAGAAGCACTGGATCCAAAGCATGTCTGCAACCCAGCCATTTTCAGGCTAATAGCT
CGTCAGCTTGCTAAAATCCATGCTATTCATGCACACAATGGCTGGATCCCCAAATCTAAT
CTTTGGCTAAAGATGGGAAAGTATTTCTCTCTCATTCCCACAGGATTTGCAGATGAAGAC
ATTAATAAAAGGTTCCTAAGTGATATCCCAAGCTCTCAGATTCTCCAGGAAGAGATGACT
TGGATGAAGGAGATTCTTTCCAACCTGGGCTCACCTGTTGTGCTTTGCCATAATGACCTA
TTGTGTAAGAATATAATCTACAATGAGAAACAAGGTGATGTACAGTTCATTGATTATGAA
TATTCTGGATACAACTACCTGGCATATGATATTGGAAATCATTTCAATGAATTTGCAGGT
GTGAGTGATGTAGACTATAGTCTGTATCCAGATAGAGAACTACAGAGTCAGTGGCTGCGT
GCTTACCTTGAAGCCTACAAAGAATTTAAGGGCTTTGGGACTGAAGTTACTGAAAAGGAG
GTAGAAATACTCTTCATTCAAGTCAATCAGTTTGCATTGGGTGAAAACTTGAATTTTATC
ATTGGCAACAAATATTGTCAGTTATTTTCACTGAAATGGCTTCTCATTTCTTTTGGGGAT
TGTGGGCTTTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
AL137750

# Metabolic_Enzyme_8_Chromosome_Location:
Not Available

# Metabolic_Enzyme_8_Locus:
Not Available

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
Not Available

# Metabolic_Enzyme_8_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7549

# Macromolecular_Interacting_Partner_1_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
INS

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_1_Signals:
1-24

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
INS

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11p15.5

# Macromolecular_Interacting_Partner_1_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_1_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_1_References:
7654263; 8602830; 8643029; 8665397

# Macromolecular_Interacting_Partner_2_ID:
6057

# Macromolecular_Interacting_Partner_2_Name:
Choline kinase alpha

# Macromolecular_Interacting_Partner_2_Synonyms:
CK; CHETK-alpha

# Macromolecular_Interacting_Partner_2_Gene_Name:
CHKA

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Choline kinase alpha
MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPP
PPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGL
SNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQVRSCNKEGSEQAQKENEFQGAEAMVLE
SVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELGLPDISAEIAEKMATFHGMKM
PFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPV
VFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYP
FFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLW
GQWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
457

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
52202

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.52

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  nutrient reservoir activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Cell wall/membrane/envelope biogenesis 

# Macromolecular_Interacting_Partner_2_Specific_Function:
May have a regulatory role in phosphatidylcholine synthesis

# Macromolecular_Interacting_Partner_2_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00564  Glycerophospholipid metabolism

# Macromolecular_Interacting_Partner_2_Reaction:
ATP + choline = ADP + O-phosphocholine

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF01633:Choline_kinase

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
EC 2.7.1.32

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
219541

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
CHKA_HUMAN (P35790)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
CHKA

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
CHKA

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:1937

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1371 bp
ATGAAAACCAAATTCTGCACCGGGGGCGAGGCGGAGCCCTCGCCGCTCGGGCTGCTGCTG
AGCTGCGGTAGCGGCAGCGCGGCCCCGGCGCCCGGCGTGGGGCAGCAGCGCGACGCCGCC
AGCGACCTCGAGTCCAAGCAGCTGGCGCCAACAGCCGCGCTCGCGCTGCCCCCTCCGCCG
CCGCTGCCGCTGCCGCTGCCGCTGCCCCAGCCCCCGCCGCCGCAGCCGCCCGCAGACGAG
CAGCCGGAGCCCCGGGCGCGGCGCAGGGCCTATCTGTGGTGCAAGGAGTTCCTGCCCGGC
GCCTGGCGGGGCCTCCGCGAGGACGAGTTCCACATCAGTGTCATCAGAGGCGGCCTTAGC
AACATGCTGTTCCAGTGCTCCCTACCTGACACCACAGCCACCCTTGGTGATGAGCCTCGG
AAAGTGCTCCTGCGGCTGTATGGAGCGATTTTGCAGATGAGGTCCTGTAATAAAGAGGGA
TCCGAACAAGCTCAGAAAGAAAATGAATTTCAAGGGGCTGAGGCCATGGTTCTGGAGAGC
GTTATGTTTGCCATTCTCGCAGAGAGGTCACTTGGGCCAAAACTCTATGGCATCTTTCCC
CAAGGCCGACTGGAGCAGTTCATCCCGAGCCGGCGATTAGATACTGAAGAATTAAGTTTG
CCAGATATTTCTGCAGAAATCGCCGAGAAAATGGCTACATTTCATGGTATGAAAATGCCA
TTCAATAAGGAACCAAAATGGCTTTTTGGCACAATGGAAAAGTATCTAAAGGAAGTGCTG
AGAATTAAATTTACTGAGGAATCCAGAATTAAAAAGCTCCACAAATTGCTCAGTTACAAT
CTGCCCTTGGAACTGGAAAACCTGAGATCATTGCTTGAATCTACTCCATCTCCAGTTGTA
TTTTGTCATAATGACTGTCAAGAAGGTAATATCTTGTTGCTGGAAGGCCGAGAGAATTCT
GAAAAACAGAAACTGATGCTCATTGATTTCGAATACAGCAGTTACAATTACAGGGGATTC
GACATTGGAAATCACTTCTGTGAGTGGATGTATGATTATAGCTATGAAAAATACCCTTTT
TTCAGAGCAAACATCCGGAAGTATCCCACCAAGAAACAACAGCTCCATTTTATTTCCAGT
TACTTGCCTGCATTCCAAAATGACTTTGAAAACCTCAGTACTGAAGAAAAATCCATTATA
AAAGAAGAAATGTTGCTTGAAGTTAATAGGTTTGCCCTTGCATCTCATTTCCTCTGGGGA
CTGTGGTCCATTGTACAAGCCAAGATTTCATCTATTGAATTTGGGTACATGGACTACGCC
CAAGCAAGGTTTGATGCCTATTTCCACCAGAAGAGGAAGCTTGGGGTGTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
D10704

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_2_Locus:
11q13.2

# Macromolecular_Interacting_Partner_2_SNPs:
rs11481; rs3794186; rs2457179; rs2511437; rs2512611; rs2457180; rs2511439; rs2512608; rs3133327; rs10791956; rs4073551; rs4930557; rs10791957; rs7127838; rs11228130; rs6591331; rs7928739; rs7123183; rs3819255; rs2512612; rs2298838; rs7925423; rs7950522; rs3763944; rs7925022; rs2511436; rs11228131; rs7940217; rs7938199; rs7925469; rs7937999; rs12807448; rs7950397; rs7950573; rs4420277; rs7123035; rs4930227; rs7938921; rs11228129; rs3763945; rs17597141; rs7104982; rs11535788; rs4424674; rs12808793; rs11228136; rs3935460; rs7950392; rs17148849; rs2512613; rs10896293; rs7950931; rs7123668; rs2512605; rs7105399; rs7938618; rs4564342; rs11228137; rs17853642; rs17853641; rs17857113; rs34553252; rs11538783; rs35157598; rs11457659; rs35617414; rs35004137; rs35142362; rs35389644; rs12803471; rs34720656; rs35418990; rs11228134; rs34128268; rs35384388; rs34541282; rs34956463; rs35129218; rs35794217; rs35686875; rs34904228; rs1703432; rs12282027; rs12361957; rs12789942; rs35295698; rs1793253; rs34157126; rs34596220; rs11604971; rs35053057; rs11824199; rs34435704; rs12275388; rs35240421; rs10219148; rs35442893; rs5792434; rs35120244; rs2457178; rs35772606; rs12270493; rs34730110; rs35079920; rs35029853; rs34533021; rs36104066; rs4506665; rs35789171; rs12796123; rs10610679; rs11823508; rs34788775; rs12363368; rs11449775; rs34744029; rs34246417; rs11337805; rs11308249; rs11405927; rs34360525; rs10577551; rs34524538; rs12808580; rs12365493; rs7119627; rs12792899; rs11311764; rs35489750; rs35389934; rs12294243; rs35331639; rs11228133; rs10708078; rs11607831; rs1703439; rs35566839; rs35303746; rs35851358; rs4337046; rs2511435; rs35423222; rs35678072; rs10623242; rs3763946; rs11228135; rs34919967; rs35264251; rs35880888; rs35356476; rs1703431; rs12294244; rs9666593; rs35679572; rs35538423; rs35046555; rs35672679; rs34534250; rs35141094; rs4400816; rs4460814; rs11228132; rs12282745; rs11422466; rs10598696; rs34261785; rs12289186; rs12226861; rs10791958; rs11228127; rs12418239; rs2075609; rs2471829; rs34174828; rs34211419; rs34227834; rs35089741; rs3808974; rs3888690; rs7127090; rs7928374; rs7940113; rs7944372

# Macromolecular_Interacting_Partner_2_General_References:
1618328

# Macromolecular_Interacting_Partner_2_References:
10728571; 8934624; 9506987

# Macromolecular_Interacting_Partner_3_ID:
8395

# Macromolecular_Interacting_Partner_3_Name:
Fatty-acid amide hydrolase

# Macromolecular_Interacting_Partner_3_Synonyms:
Oleamide hydrolase; Anandamide amidohydrolase

# Macromolecular_Interacting_Partner_3_Gene_Name:
FAAH

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Fattyacid amide hydrolase
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQ
RFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLAD
CETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAV
PFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGG
SIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCE
DMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTL
VPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAF
LVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALD
LNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMK
KSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
579

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
63067

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
7.72

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Function:  amidase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_3_Specific_Function:
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF01425:Amidase

# Macromolecular_Interacting_Partner_3_Signals:
1-28

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
2149156

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
FAAH_HUMAN (O00519)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
FAAH

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
FAAH

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:3553

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Intracytoplasmic membrane; single-pass membrane protein. Cytoplasm; cytoskeleton. Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1740 bp
ATGGTGCAGTACGAGCTGTGGGCCGCGCTGCCTGGCGCCTCCGGGGTCGCCCTGGCCTGC
TGCTTCGTGGCGGCGGCCGTGGCCCTGCGCTGGTCCGGGCGCCGGACGGCGCGGGGCGCG
GTGGTCCGGGCGCGACAGAAGCAGCGAGCGGGCCTGGAGAACATGGACAGGGCGGCGCAG
CGCTTCCGGCTCCAGAACCCAGACCTGGACTCAGAGGCGCTGCTAGCCCTGCCCCTGCCT
CAGCTGGTGCAGAAGTTACACAGTAGAGAGCTGGCCCCTGAGGCCGTGCTCTTCACCTAT
GTGGGAAAGGCCTGGGAAGTGAACAAAGGGACCAACTGTGTGACCTCCTATCTGGCTGAC
TGTGAGACTCAGCTGTCTCAGGCCCCAAGGCAGGGCCTGCTCTATGGCGTCCCTGTGAGC
CTCAAGGAGTGCTTCACCTACAAGGGCCAGGACTCCACGCTGGGCTTGAGCCTGAATGAA
GGGGTGCCGGCGGAGTGCGACAGCGTAGTGGTGCATGTGCTGAAGCTGCAGGGTGCCGTG
CCCTTCGTGCACACCAATGTTCCACAGTCCATGTTCAGCTATGACTGCAGTAACCCCCTC
TTTGGCCAGACCGTGAACCCATGGAAGTCCTCCAAAAGCCCAGGGGGCTCCTCAGGGGGT
GAAGGGGCCCTCATCGGGTCTGGAGGCTCCCCCCTGGGCTTAGGCACTGATATCGGAGGC
AGCATCCGCTTCCCCTCCTCCTTCTGCGGCATCTGCGGCCTCAAGCCCACAGGGAACCGC
CTCAGCAAGAGTGGCCTGAAGGGCTGTGTCTATGGACAGGAGGCAGTGCGTCTCTCCGTG
GGCCCCATGGCCCGGGACGTGGAGAGCCTGGCACTGTGCCTGCGAGCCCTGCTGTGCGAG
GACATGTTCCGCTTGGACCCCACTGTGCCTCCCTTGCCCTTCAGAGAAGAGGTCTACACC
AGCTCTCAGCCCCTGCGTGTGGGGTACTATGAGACTGACAACTATACCATGCCCTCCCCG
GCCATGAGGCGGGCCGTGCTGGAGACCAAACAGAGCCTTGAGGCTGCGGGGCACACGCTG
GTTCCCTTCTTGCCAAGCAACATACCCCATGCTCTGGAGACCCTGTCAACAGGTGGGCTC
TTCAGTGATGGTGGCCACACCTTCCTACAGAACTTCAAAGGTGATTTCGTGGACCCCTGC
CTGGGGGACCTGGTCTCAATTCTGAAGCTTCCCCAATGGCTTAAAGGACTGCTGGCCTTC
CTGGTGAAGCCTCTGCTGCCAAGGCTGTCAGCTTTCCTCAGCAACATGAAGTCTCGTTCG
GCTGGAAAACTCTGGGAACTGCAGCACGAGATCGAGGTGTACCGCAAAACCGTGATTGCC
CAGTGGAGGGCGCTGGACCTGGATGTGGTGCTGACCCCCATGCTGGCCCCTGCTCTGGAC
TTGAATGCCCCAGGCAGGGCCACAGGGGCCGTCAGCTACACTATGCTGTACAACTGCCTG
GACTTCCCTGCAGGGGTGGTGCCTGTCACCACGGTGACTGCTGAGGACGAGGCCCAGATG
GAACATTACAGGGGCTACTTTGGGGATATCTGGGACAAGATGCTGCAGAAGGGCATGAAG
AAGAGTGTGGGGCTGCCGGTGGCCGTGCAGTGTGTGGCTCTGCCCTGGCAAGAAGAGTTG
TGTCTGCGGTTCATGCGGGAGGTGGAGCGACTGATGACCCCTGAAAAGCAGTCATCCTGA


# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
U82535

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_3_Locus:
1p35-p34

# Macromolecular_Interacting_Partner_3_SNPs:
rs324420; rs324419; rs2295633; rs6429600; rs324418; rs873978; rs3766246; rs4141964; rs6697851; rs7528704; rs17361950; rs41294524; rs6662982; rs324416; rs2145408; rs6703669; rs11576941; rs6703374; rs17361936; rs41357446; rs561392; rs2295632; rs913168; rs12029329; rs1984491; rs932816; rs11589812; rs41374548; rs34820226; rs7524148; rs12094805; rs41305628; rs12737943; rs33963518; rs17102180; rs12750468; rs35478580; rs12737786; rs35218475; rs1998186; rs10157766; rs34033903; rs35413576; rs11807478; rs35522761; rs12737787; rs35750128; rs34839737; rs324417; rs11423577; rs41309147; rs12022769; rs12568582; rs6674305; rs34238011; rs11288511; rs12086460; rs35134535; rs35421079; rs34656766; rs35934911; rs35447869; rs1150067; rs12044513; rs17102179; rs7543877; rs11326476; rs12039619; rs1984490; rs11485676; rs35686500; rs6703596; rs11488314; rs11586508; rs324415; rs11488315; rs11577389; rs1887240; rs324421; rs324423; rs324425; rs3991877; rs4660928; rs6670926; rs7520850; rs7522048; rs927898

# Macromolecular_Interacting_Partner_3_General_References:
9122178; 9878243; 12665801; 12060782

# Macromolecular_Interacting_Partner_3_References:
10820223; 12052034; 12432941; 16981687

# Macromolecular_Interacting_Partner_4_ID:
8433

# Macromolecular_Interacting_Partner_4_Name:
Phospholipase C

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
PLCL1

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Phospholipase 
CMPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAK
LDISAIKEIRLGKNTETFTNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSG
LRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKE
AKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLML
FLEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVA
QDMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILC
NRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYT
EAPLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAQMSRRMSVDYNGEQK
QIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKK
FLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRP
SIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGI
PADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFE
CLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRN
IGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSSRLITS
DNTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKIVQCQK
AGMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENMKQIQL
ACLSCGLSKAPSSSAEAKSKRSLEAIEEKESSEENGKL

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
997

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
112957

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
5.26

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  carboxylic ester hydrolase activity
Function:  lipase activity
Function:  phospholipase activity
Function:  phospholipase C activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  inositol or phosphatidylinositol phosphodiesterase activity
Function:  phosphoinositide phospholipase C activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  intracellular signaling cascade
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00168:C2;
PF00169:PH;
PF00388:PI-PLC-X;
PF00387:PI-PLC-Y

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
780122

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
Q15111_HUMAN (Q15111)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
PLCL1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
PLCL1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:9063

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>2994 bp
ATGCCATCGGAAAAGAAAATTAGCAGTGCAAATGACTGCATCAGCTTCATGCAAGCTGGC
TGTGAGTTGAAGAAAGTCCGGCCAAATTCTCGCATTTACAACCGTTTTTTCACTCTGGAC
ACAGACCTTCAAGCTCTTCGCTGGGAACCTTCAAAGAAAGACCTCGAGAAAGCCAAGCTT
GATATTTCTGCCATAAAAGAGATCAGACTGGGGAAAAACACGGAAACATTTACAAACAAT
GGCCTTGCTGACCAGATCTGTGAGGACTGTGCCTTTTCCATACTCCACGGGGAAAACTAT
GAGTCTCTGGACCTAGTTGCCAATTCAGCAGATGTGGCAAACATCTGGGTGTCTGGGTTA
CGGTACCTGGTTTCTCGAAGTAAGCAGCCTCTTGATTTTATGGAGGGCAACCAGAACACA
CCACGGTTCATGTGGTTGAAAACAGTGTTTGAAGCAGCAGATGTTGATGGGAATGGGATT
ATGTTGGAAGACACCTCTGTAGAGTTAATAAAACAACTCAACCCTACTCTGAAGGAAGCC
AAGATCAGGTTAAAGTTTAAAGAAATCCAGAAGAGCAAGGAAAAACTAACCACCCGCGTG
ACCGAAGAGGAATTTTGTGAAGCTTTTTGTGAACTTTGCACCAGGCCAGAAGTGTATTTC
TTACTTGTACAGATATCTAAAAACAAAGAATATTTGGATGCCAATGATCTCATGCTCTTT
TTAGAAGCTGAGCAAGGAGTCACCCATATCACCGAGGATATATGCTTAGACATCATAAGG
AGATACGAACTTTCTGAAGAGGGACGTCAAAAAGGGTTTCTTGCAATTGATGGCTTTACC
CAGTATTTATTGTCATCAGAATGTGACATTTTTGATCCTGAGCAAAAGAAGGTTGCCCAA
GATATGACCCAGCCATTATCTCACTACTATATCAATGCCTCTCATAACACCTATCTAATA
GAAGACCAGTTCAGGGGGCCAGCTGACATCAATGGGTACATTAGAGCTTTGAAAATGGGC
TGTCGAAGCGTTGAACTCGATGTAAGTGATGGTTCAGATAATGAACCAATCCTTTGTAAT
CGAAATAACATGACAACCCATGTTTCCTTTCGAAGTGTCATAGAGGTAATAAATAAATTT
GCCTTTGTTGCTTCTGAATACCCACTCATTCTTTGCTTGGGAAATCACTGCTCCTTGCCG
CAGCAGAAGGTAATGGCTCAACAGATGAAAAAGGTCTTTGGCAATAAACTCTATACTGAA
GCACCTTTGCCCTCAGAATCCTACCTCCCATCACCAGAAAAATTAAAAAGAATGATCATT
GTGAAAGGAAAGAAGTTGCCTTCTGATCCAGATGTGTTAGAAGGAGAAGTAACAGATGAA
GATGAAGAAGCTCAAATGTCTCGAAGGATGTCGGTAGATTACAATGGTGAGCAGAAGCAA
ATCCGACTCTGTAGGGAGCTCTCTGATTTGGTGTCTATTTGTAAATCTGTTCAATACAGG
GATTTTGAACTATCTATGAAAAGCCAAAACTATTGGGAAATGTGTTCATTTAGTGAAACA
GAGGCCAGCCGCATTGCAAATGAGTACCCAGAGGATTTTGTTAATTATAATAAGAAGTTC
TTATCAAGAATCTATCCAAGTGCCATGAGGATCGATTCCAGTAACTTGAATCCACAGGAC
TTTTGGAATTGTGGCTGTCAGATTGTAGCAATGAATTTTCAGACTCCGGGTCCAATGATG
GACCTTCACACGGGCTGGTTTCTTCAAAACGGGGGATGTGGTTATGTTCTAAGGCCGTCT
ATAATGCGAGATGAAGTTTCTTACTTCAGCGCAAATACAAAGGGCATTCTACCTGGGGTG
TCTCCTCTAGCTCTTCATATCAAGATCATCAGTGGTCAGAATTTCCCAAAGCCCAAGGGA
GCTTGTGCCAAAGGGGATGTCATAGATCCCTATGTTTGTATAGAGATACACGGAATTCCA
GCGGATTGTTCGGAACAAAGAACTAAAACTGTACAGCAAAACAGTGATAATCCTATTTTT
GATGAAACTTTTGAGTTCCAAGTAAACCTACCTGAGCTGGCCATGATCCGTTTTGTTGTT
CTGGATGATGACTACATTGGGGATGAGTTTATAGGGCAATATACGATACCATTTGAATGT
TTGCAGCCTGGATATCGGCATGTTCCCCTGCGTTCTTTTGTGGGTGACATCATGGAGCAC
GTAACCCTTTTTGTCCACATAGCAATAACTAATCGAAGTGGAGGAGGAAAGGCACAGAAG
CGCAGTCTTTCAGTGAGAATGGGGAAGAAAGTTCGGGAATATACCATGCTCAGGAATATC
GGTCTTAAAACCATTGATGACATCTTTAAAATAGCGGTTCATCCATTACGAGAAGCCATA
GATATGAGAGAAAATATGCAGAATGCAATCGTGTCTATTAAGGAACTATGTGGACTCCCT
CCAATTGCCAGTCTGAAGCAGTGCCTGTTAACTCTGTCATCTCGGCTCATCACCAGTGAC
AATACTCCTTCAGTCTCACTTGTGATGAAAGACAGCTTTCCTTACCTGGAGCCTCTGGGT
GCAATTCCAGATGTGCAGAAAAAGATGCTGACTGCTTATGATCTGATGATTCAAGAGAGC
CGGTTTCTCATAGAAATGGCGGACACAGTCCAGGAAAAGATTGTACAGTGTCAGAAAGCA
GGGATGGAGTTCCATGAAGAACTTCATAATTTGGGGGCAAAAGAAGGCTTGAAGGGAAGA
AAACTCAACAAAGCAACTGAGAGCTTTGCTTGGAACATTACAGTATTGAAGGGCCAAGGA
GATCTGTTGAAGAATGCCAAGAATGAAGCTATAGAAAACATGAAGCAGATCCAGCTGGCA
TGCCTGTCCTGTGGACTGAGTAAAGCCCCCAGCAGCAGTGCTGAGGCCAAGAGCAAGCGC
AGCCTGGAAGCCATAGAGGAGAAGGAAAGTAGTGAGGAGAATGGGAAGCTGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
D42108

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_4_Locus:
2q33

# Macromolecular_Interacting_Partner_4_SNPs:
rs1064213; rs2228135; rs745899; rs1318867; rs1440090; rs1813106; rs1866666; rs1866664; rs1147169; rs2342558; rs976179; rs1036333; rs976180; rs1976772; rs1541953; rs1837495; rs2053394; rs2117339; rs1440087; rs7420608; rs6434955; rs2165237; rs6434949; rs7582715; rs7587251; rs7590828; rs1992313; rs11889006; rs1440091; rs13382697; rs7581202; rs10190226; rs7600269; rs6726506; rs2196171; rs1401096; rs7592556; rs1371664; rs6434953; rs10497809; rs1368989; rs7572733; rs10184395; rs2196176; rs6716898; rs1016883; rs6434954; rs1025549; rs4410288; rs1518369; rs10196612; rs1304164; rs1607376; rs6715070; rs10184227; rs6738825; rs1866665; rs7573001; rs892514; rs6752454; rs6434950; rs893808; rs11901757; rs10497810; rs7571545; rs6434951; rs7563170; rs10177758; rs882954; rs1850631; rs2164070; rs12693829; rs1371663; rs2139049; rs1961425; rs16826873; rs1401097; rs10204166; rs13394871; rs6745726; rs7602602; rs1518359; rs1595825; rs13408411; rs2119168; rs11683222; rs10931796; rs10497813; rs1579695; rs16827521; rs1850633; rs11890137; rs6434948; rs12105927; rs11891555; rs892513; rs10207232; rs1583792; rs11903129; rs7568948; rs1371665; rs2139050; rs7587598; rs2164071; rs6752458; rs2342557; rs7587043; rs1356542; rs7571869; rs1595823; rs6736825; rs10169453; rs11679484; rs7576221; rs4850818; rs1595824; rs2196172; rs1440089; rs17790682; rs2342556; rs16827267; rs16826320; rs6741701; rs7573687; rs2196175; rs6748683; rs16826791; rs6752760; rs11681663; rs16826895; rs16827456; rs16826872; rs10497811; rs1978888; rs6732517; rs4595967; rs7349300; rs13397178; rs10931798; rs736367; rs16827465; rs1440088; rs11889326; rs10195621; rs10191173; rs10206714; rs17520121; rs12465450; rs11690149; rs10497812; rs10166845; rs1440086; rs11689393; rs1836234; rs5007118; rs10175510; rs2342555; rs11895260; rs4549082; rs6724526; rs11676006; rs35730302; rs17791296; rs892512; rs12623270; rs7579905; rs1518368; rs4417706; rs11690205; rs2164068; rs9712275; rs16826740; rs9973400; rs2196174; rs10931797; rs1371657; rs2009631; rs1036334; rs1808850; rs892515; rs2880366; rs989056; rs1036336; rs1371661; rs3771359; rs10180112; rs3771365; rs6758876; rs3771361; rs1821430; rs6434956; rs2164069; rs3755333; rs11681576; rs1440084; rs3755330; rs13420295; rs7570678; rs1946645; rs7571896; rs4850820; rs2033570; rs10200317; rs11884188; rs10931800; rs1304358; rs6755925; rs3732231; rs10200463; rs3771370; rs3771368; rs1978890; rs4850819; rs7595412; rs3771362; rs16827896; rs11895223; rs10168722; rs6752980; rs11674075; rs3771367; rs16827851; rs12476465; rs11904843; rs16827918; rs10497814; rs1036335; rs12613073; rs12693831; rs10497815; rs986534; rs11884454; rs988583; rs1371659; rs13397026; rs3755332; rs12473467; rs17792650; rs4850821; rs7607044; rs13426297; rs12614662; rs2033569; rs11883868; rs16827593; rs16827819; rs13416439; rs16827923; rs12472100; rs10168721; rs13392163; rs16827729; rs7603309; rs16827916; rs1371660; rs12618469; rs16827788; rs4850822; rs3771369; rs12612977; rs17672607; rs13429722; rs16827921; rs10173738; rs3213867; rs3732232; rs16827694; rs1371658; rs11684176; rs1464209; rs1518360; rs1464210; rs6741084; rs34548437; rs4850441; rs35514871; rs34914408; rs34834250; rs35360200; rs1304165; rs34838834; rs7562132; rs11423327; rs35710464; rs1169458; rs34319496; rs12998989; rs36064148; rs35925285; rs11465077; rs9753097; rs10689149; rs13000637; rs34942811; rs35492290; rs5837576; rs2119169; rs34997942; rs34892290; rs35503807; rs34953848; rs34913887; rs10646938; rs35293068; rs13401268; rs1147168; rs35428842; rs11399169; rs34335129; rs13000419; rs1829358; rs1850634; rs34992068; rs35337305; rs13022936; rs4325749; rs34157959; rs11300427; rs35563720; rs6707815; rs13408177; rs34867071; rs4555344; rs3068250; rs5837578; rs35507350; rs3068222; rs34229236; rs36116085; rs13388318; rs34825619; rs13030657; rs34072014; rs16827438; rs35828708; rs13024144; rs12621502; rs10206257; rs35989106; rs11675025; rs34824539; rs34739422; rs35385198; rs35459961; rs6706633; rs35811589; rs34464991; rs36071237; rs10221706; rs34848522; rs11450711; rs34198712; rs34158633; rs13030838; rs34237103; rs13000620; rs6732340; rs7424606; rs34240767; rs4278926; rs35062652; rs10189006; rs34692727; rs6756641; rs16827329; rs2176544; rs5837579; rs962210; rs35829267; rs28482067; rs10667979; rs13004559; rs17671147; rs34246898; rs10560234; rs1713577; rs11288289; rs34031345; rs35421632; rs34388051; rs28513170; rs35801426; rs10202569; rs13393153; rs34014508; rs34706360; rs34491506; rs34068355; rs34987767; rs4533466; rs35008316; rs1147167; rs7424557; rs35718463; rs4608507; rs35657897; rs34941542; rs35445183; rs35928454; rs5837575; rs7558450; rs13000628; rs13023829; rs13004536; rs11299150; rs34645327; rs34834215; rs7426250; rs1655551; rs35338467; rs35242855; rs13024135; rs35320812; rs10460395; rs955946; rs35119264; rs7567065; rs35333689; rs5837580; rs7585709; rs1850632; rs10552265; rs35071499; rs34584459; rs13387909; rs34894143; rs35035575; rs35429199; rs1630802; rs7559096; rs1978889; rs11423326; rs35638208; rs10708293; rs35226018; rs5837577; rs1878731; rs13394317; rs7424623; rs13000646; rs35852164; rs6732890; rs35291437; rs13402162; rs12329164; rs13014089; rs35988912; rs10175996; rs35207799; rs13000632; rs34809958; rs7582419; rs12999367; rs35151065; rs35334258; rs6722831; rs7608078; rs995925; rs34560060; rs35240938; rs41471147; rs41270239; rs10586893; rs16827882; rs3066169; rs34500216; rs7599640; rs2859806; rs7564543; rs35294687; rs11899729; rs3836135; rs17672571; rs3841904; rs13408403; rs10180081; rs1434287; rs34102559; rs3771366; rs35268804; rs34344108; rs34866078; rs10556429; rs34226193; rs34911573; rs34171660; rs11272623; rs989055; rs35362582; rs35725774; rs1440085; rs34046717; rs6730643; rs13001951; rs2196173; rs13030009; rs35609455; rs13003306; rs41468149; rs10200278; rs1371662; rs35508591; rs35772757; rs35378638; rs5837581; rs35954045; rs35894231; rs12386136; rs5837583; rs35357926; rs6747060; rs13431790; rs3755331; rs16827822; rs10931799; rs34268063; rs35495812; rs3836134; rs12467181; rs35978517; rs7606075; rs7588399; rs35276939; rs28685259; rs12619399; rs13003522; rs6711776; rs34384419; rs11393208; rs10180395; rs13416760; rs4850442; rs2859982; rs13003292; rs35626074; rs3821245; rs10556428; rs35502355; rs3771360; rs6706528; rs13391892; rs34566439; rs11357860; rs1304359; rs13430380; rs35132481; rs34119275; rs5837582; rs7557783; rs13385675; rs7572854; rs10680188; rs34754910; rs35012933; rs10189897; rs10207433; rs11887138; rs11899950; rs12612986; rs1401090; rs1440083; rs1518361; rs1518362; rs1518363; rs1518364; rs1518365; rs1518366; rs1518367; rs1878732; rs1914690; rs4850823; rs938928

# Macromolecular_Interacting_Partner_4_General_References:
7633416

# Macromolecular_Interacting_Partner_4_References:
7744844; 7820250; 9409283

# Macromolecular_Interacting_Partner_5_ID:
8475

# Macromolecular_Interacting_Partner_5_Name:
Phosphatidylserine synthase 2

# Macromolecular_Interacting_Partner_5_Synonyms:
PtdSer synthase 2; PSS-2; Serine-exchange enzyme II

# Macromolecular_Interacting_Partner_5_Gene_Name:
PTDSS2

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Phosphatidylserine synthase 2
MRRGERRDAGGPRPESPVPAGRASLEEPPDGPSAGQATGPGEGRRSTESEVYDDGTNTFF
WRAHTLTVLFILTCTLGYVTLLEETPQDTAYNTKRGIVASILVFLCFGVTQAKDGPFSRP
HPAYWRFWLCVSVVYELFLIFILFQTVQDGRQFLKYVDPKLGVPLPERDYGGNCLIYDPD
NETDPFHNIWDKLDGFVPAHFLGWYLKTLMIRDWWMCMIISVMFEFLEYSLEHQLPNFSE
CWWDHWIMDVLVCNGLGIYCGMKTLEWLSLKTYKWQGLWNIPTYKGKMKRIAFQFTPYSW
VRFEWKPASSLRRWLAVCGIILVFLLAELNTFYLKFVLWMPPEHYLVLLRLVFFVNVGGV
AMREIYDFMDDPKPHKKLGPQAWLVAAITATELLIVVKYDPHTLTLSLPFYISQCWTLGS
VLALTWTVWRFFLRDITLRYKETRWQKWQNKDDQGSTVGNGDQHPLGLDEDLLGPGVAEG
EGAPTPN

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
487

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
56253

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.19

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
 Function:  Not Available
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  phospholipid metabolism
Process:  glycerophospholipid metabolism
Process:  phosphatidylserine metabolism
Process:  phosphatidylserine biosynthesis
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF03034:PSS

# Macromolecular_Interacting_Partner_5_Signals:
Not Available

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
63-83
97-117
127-147
242-262
314-334
336-356
377-397
404-424

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
21740008

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
PTSS2_HUMAN (Q9BVG9)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
PTDSS2

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
PTDSS2

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:15463

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1464 bp
ATGCGGAGGGGCGAGCGCAGGGACGCCGGAGGTCCGCGGCCCGAGTCCCCGGTGCCCGCG
GGCAGGGCCTCGCTGGAGGAGCCGCCTGACGGGCCGTCTGCCGGCCAAGCCACCGGGCCG
GGCGAGGGCCGCCGCAGCACCGAGTCCGAGGTCTACGACGACGGCACCAACACCTTCTTC
TGGCGAGCCCACACCTTAACCGTGCTCTTCATCCTCACCTGTACGCTTGGCTATGTGACG
CTGCTGGAGGAAACACCTCAGGACACGGCCTACAACACCAAGAGAGGTATTGTGGCCAGT
ATTTTGGTTTTCTTATGTTTTGGAGTCACACAAGCTAAAGACGGGCCATTTTCCAGACCT
CATCCAGCTTACTGGAGGTTTTGGCTCTGCGTGAGTGTGGTCTACGAGCTGTTTCTCATC
TTTATACTCTTCCAGACTGTCCAGGACGGCCGGCAGTTTCTAAAGTATGTTGACCCCAAG
CTGGGAGTCCCACTGCCAGAGAGAGACTACGGGGGAAACTGCCTCATCTACGACCCAGAC
AATGAGACTGACCCCTTTCACAACATCTGGGACAAGTTGGATGGCTTTGTTCCCGCGCAC
TTTCTTGGCTGGTACCTGAAGACCCTGATGATCCGAGACTGGTGGATGTGCATGATCATC
AGCGTGATGTTCGAGTTCCTGGAGTACAGCCTGGAGCACCAGCTGCCCAACTTCAGCGAG
TGCTGGTGGGATCACTGGATCATGGACGTGCTCGTCTGCAACGGGCTGGGCATCTACTGC
GGCATGAAGACCCTTGAGTGGCTGTCCCTGAAGACGTACAAGTGGCAGGGCCTCTGGAAC
ATTCCGACCTACAAGGGCAAGATGAAGAGGATCGCCTTCCAGTTCACGCCGTACAGCTGG
GTTCGCTTCGAGTGGAAGCCGGCCTCCAGCCTGCGTCGCTGGCTGGCCGTGTGCGGCATC
ATCCTGGTGTTCCTGTTGGCAGAACTGAACACGTTCTACCTGAAGTTTGTGCTGTGGATG
CCCCCGGAGCACTACCTGGTCCTCCTGCGGCTCGTCTTCTTCGTGAACGTGGGTGGCGTG
GCCATGCGTGAGATCTACGACTTCATGGATGACCCGAAGCCCCACAAGAAGCTGGGCCCG
CAGGCCTGGCTGGTGGCGGCCATCACGGCCACGGAGCTGCTCATCGTGGTGAAGTACGAC
CCCCACACGCTCACCCTGTCCCTGCCCTTCTACATCTCCCAGTGCTGGACCCTCGGCTCC
GTCCTGGCGCTCACCTGGACCGTCTGGCGCTTCTTCCTGCGGGACATCACATTGAGGTAC
AAGGAGACCCGGTGGCAGAAGTGGCAGAACAAGGATGACCAGGGCAGCACCGTCGGCAAC
GGGGACCAGCACCCACTGGGGCTGGACGAAGACCTGCTGGGGCCTGGGGTGGCCGAGGGC
GAGGGAGCACCAACTCCAAACTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AL834357

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_5_Locus:
11p15

# Macromolecular_Interacting_Partner_5_SNPs:
rs1044707; rs7121599; rs6598017; rs7935013; rs7940821; rs767086; rs7931534; rs3888797; rs2613996; rs11823647; rs7945673; rs7950520; rs6598016; rs11246164; rs7925484; rs9667049; rs12799388; rs7118621; rs11821392; rs9666582; rs11825931; rs9667303; rs7108959; rs11821341; rs4963194; rs7127967; rs12418639; rs7937939; rs9328565; rs4963139; rs7925729; rs7949115; rs9795283; rs12576945; rs7928814; rs2301172; rs4963135; rs7110400; rs6598018; rs2856239; rs7117853; rs7942404; rs12803629; rs12798676; rs7935018; rs7939891; rs4963138; rs12790188; rs12576322; rs9736326; rs7941276; rs7937085; rs7945922; rs7939892; rs211520; rs12807886; rs12417570; rs7940939; rs9795284; rs12806187; rs17155870; rs12803838; rs7113255; rs12575419; rs11602898; rs12794284; rs7394670; rs7101861; rs7482616; rs11539812; rs34809643; rs11539813; rs11539814; rs11600323; rs11539815; rs9736719; rs2301169; rs10698834; rs35716989; rs34585513; rs36058901; rs11821959; rs1056506; rs7103786; rs34083507; rs176938; rs9795451; rs12798512; rs35311379; rs35068485; rs7105294; rs4963196; rs2301171; rs7127572; rs172441; rs12099377; rs12099375; rs34665187; rs211531; rs10698835; rs35898083; rs211521; rs3082636; rs11820122; rs7945914; rs36117472; rs7115664; rs34612778; rs35669491; rs12804384; rs7109207; rs7105974; rs11602979; rs10615411; rs34340365; rs211530; rs34831699; rs211522; rs34836032; rs35908275; rs4963195; rs34385146; rs3216784; rs12223359; rs36051705; rs34519965; rs11821447; rs12275194; rs211532; rs12798758; rs35275997; rs9667879; rs10128578; rs9794846; rs11822000; rs12417681; rs35683840; rs35323970; rs35906014; rs10698836; rs211529; rs28591970; rs34255371; rs34645733; rs34526529; rs2301168; rs12574094; rs12363435; rs4963193; rs11821448; rs11823439; rs34876950; rs35389167; rs7108364; rs10698837; rs36108966; rs7931053; rs2301170; rs35996687; rs7947963; rs12280302; rs7123715; rs7110722; rs12362713; rs12803626; rs35375490; rs34720250; rs33967553; rs35859071; rs6598019; rs1049499; rs10540; rs11246165; rs11246166; rs11607572; rs11825121; rs12417451; rs12419209; rs17584; rs17585; rs176939; rs211526; rs211527; rs3177784; rs34136715; rs35608427; rs35800583; rs35811812; rs36001698; rs36042148; rs3781612; rs3868121; rs3868122; rs3868123; rs3895648; rs4963190; rs6598020; rs7113204; rs7118425; rs7131513; rs7924341; rs7933587; rs7983

# Macromolecular_Interacting_Partner_5_General_References:
Not Available

# Macromolecular_Interacting_Partner_5_References:
Not Available

End of HMDB00149

Beginning of HMDB00150
# Accession_No:
HMDB00150

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-05-23 13:48:44

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Gluconolactone

# Description:
A lactone or oxidized derivative of glucose.  Gluconolactone is a polyhydroxy acid (PHA) that is capable of chelating metals and may also function by scavenging free radicals, thereby protecting skin from some of the damaging effects of UV radiation. Also used as a pheromone by the oriental cockroach.

# Synonyms:
1,5-Gluconolactone; 3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-one; Beta-Glucono-1,5-Lactone; D(+)-Gluconic acid gamma-lactone; D-(+)-Gluconic acid d-lactone; D-(+)-Gluconic acid-delta lactone; D-Gluconic acid 1,5-lactone; D-Gluconic acid d-lactone; D-Gluconic acid delta-lactone; D-Gluconic acid lactone; D-Gluconic acid-1,5-lactone; D-Glucono-1,5-lactone; D-Glucono-d-lactone; D-Gluconolactone; Fujiglucon; Glucarolactone; Gluconic acid lactone; Gluconic lactone; Glucono 1,5-lactone; Glucono delta lactone; Glucono gamma-lactone; Gluconolactone; d-Aldonolactone; delta-Gluconolactone; gamma-Gluconolactone; delta-(+)-Gluconic acid d-lactone; delta-(+)-Gluconic acid-delta lactone; delta-Gluconic acid 1,5-lactone; delta-Gluconic acid d-lactone; delta-Gluconic acid delta-lactone; delta-Gluconic acid lactone; delta-Gluconic acid-1,5-lactone; delta-Glucono-1,5-lactone; delta-Glucono-delta-lactone; delta-Aldonolactone

# Chemical_IUPAC_Name:
3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-one

# Chemical_Formula:
C6H10O6

# Chemical_Structure:
tbl_chemical:::HMDB00150_ZOOM.png:::119283218851985053

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00150_THUMB.png:::119283218697273635

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Sugars; Lactones; Monosaccharides

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary alcohol; secondary alcohol; 1,2-diol; carboxylic acid ester; lactone; heterocyclic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
178.04773

# Molecular_Weight_Avg:
178.14000

# Smiles_String_isomeric:
OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O

# Smiles_String_canonical:
OCC1OC(=O)C(O)C(O)C1O

# KEGG_Compound_ID:
C00198

# BioCyc_ID:
GLC-D-LACTONE

# PubChem_CID:
7027

# PubChem_SID:
836431; 7888635; 837970; 8144694; 8154626; 11528377; 606502; 3498; 12101574; 150049; 854851

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Gluconolactone

# METLIN_ID:
353

# Ref_ID:
1797843; 3128683; 1303072; 3747452; 2142103; 2148055; 8457606; 3951202

# ChEBI_ID:
16217

# CAS_Registry_Number:
90-80-2

# InChI:
InChI=1/C6H10O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-5,7-10H,1H2/t2-,3-,4+,5-/m1/s1

# Synthesis_Reference:
Journal of the American Chemical Society  (1950),  72  2866-7.

# Melting_Point:
151-155 oC

# Melting_Point_predicted:
103.3 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
590.0 mg/mL [MERCK INDEX (1996)]

# H2O_Solubility_Predicted:
586.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.15 [Predicted by ALOGPS]; -1.8 [Predicted by PubChem via XLOGP]; -1.98 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00198.mol:::1132723810171756528

# SDF_File_[Text]:
tbl_chemical:::HMDB00150.sdf:::119283218246277008

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00150.pdb:::119283218562615906

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041024_P00_04_HW_1DP_presat.png:::114866519790570894

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041024_P00_04_HW_1DP_presat.zip:::114866519792213297

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041024_P00_04_HW_1DP_Assigned.png:::11611148850474220

# C_NMR_Spectra:
tbl_cnmr:::041024_P00_04_HW_1DC_114.jpg:::11416845981077198

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041024_P00_04_HW_1DC_114.zip:::114168459807685603

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041024_P00_04_HW_1DC_114_Assigned.jpg:::115982958946867142

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041024_P00_04_HW_2DHSQC_414.jpg:::114617313248399559

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041024_P00_04_HW_2DHSQC_414.zip:::114617313249348483

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041024_P00_04_HW_2DHSQC_414_Assigned.jpg:::115982963589986121

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Glucono 1,5-lactone.gif:::1132732114187300696

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00150_peaks.txt:::1156309577225230580

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Glucono 1,5-lactone_C.gif:::1132737700359909532

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00150_peaks.txt:::1156310767048949865

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00150.png:::1165435124944866702; Medium Energy:tbl_ms:::HMDB00150.png:::1165434558572127485; High Energy:tbl_ms:::HMDB00150.png:::1165434752372689327

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000230.png:::116907445004671098

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000230.txt:::116907445004652518

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000230.png:::116890832218751287

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000230.txt:::116890832268790750

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Not Available

# Concentration_[Normal]:
Not Available


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Galactosemia

# Pathway_Names:
Starch and sucrose metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00500

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5612

# Metabolic_Enzyme_1_Name:
Glycogen phosphorylase, brain form

# Metabolic_Enzyme_1_Synonyms:
Not Available

# Metabolic_Enzyme_1_Gene_Name:
PYGB

# Metabolic_Enzyme_1_Protein_Sequence:
>Glycogen phosphorylase, brain form
MAKPLTDSEKRKQISVRGLAGLGDVAEVRKSFNRHLHFTLVKDRNVATPRDYFFALAHTV
RDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTMVNLGLQNACDEAIYQLGLDL
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKIVNGWQVEEA
DDWLRYGNPWEKARPEYMLPVHFYGRVEHTPDGVKWLDTQVVLAMPYDTPVPGYKNNTVN
TMRLWSAKAPNDFKLQDFNVGDYIEAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTCFETFPDKVAIQLNDTHPALSIPELMRILVDVEKV
DWDKAWEITKKTCAYTNHTVLPEALERWPVSMFEKLLPRHLEIIYAINQRHLDHVAALFP
GDVDRLRRMSVIEEGDCKRINMAHLCVIGSHAVNGVARIHSEIVKQSVFKDFYELEPEKF
QNKTNGITPRRWLLLCNPGLADTIVEKIGEEFLTDLSQLKKLLPLVSDEVFIRDVAKVKQ
ENKLKFSAFLEKEYKVKINPSSMFDVHVKRIHEYKRQLLNCLHVVTLYNRIKRDPAKAFV
PRTVMIGGKAAPGYHMAKLIIKLVTSIGDVVNHDPVVGDRLKVIFLENYRVSLAEKVIPA
ADLSQQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGAENLFIFGLRVEDVE
ALDRKGYNAREYYDHLPELKQAVDQISSGFFSPKEPDCFKDIVNMLMHHDRFKVFADYEA
YMQCQAQVDQLYRNPKEWTKKVIRNIACSGKFSSDRTITEYAREIWGVEPSDLQIPPPNI
PRD

# Metabolic_Enzyme_1_Number_of_Residues:
843

# Metabolic_Enzyme_1_Molecular_Weight:
96697

# Metabolic_Enzyme_1_Theoretical_pI:
6.85

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
Function:  phosphorylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

# Metabolic_Enzyme_1_Pathway:
map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_1_Reaction:
(1,4-alpha-D-glucosyl)n + phosphate = (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00343:Phosphorylase

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.1.1

# Metabolic_Enzyme_1_GenBank_ID_Protein:
307200

# Metabolic_Enzyme_1_SwissProt_ID:
PYGB_HUMAN (P11216)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
PYGB

# Metabolic_Enzyme_1_Geneatlas_id:
PYGB

# Metabolic_Enzyme_1_hgnc_id:
HGNC:9723

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>2592 bp
ATGGGCGAACCGCTGACGGACAGCGAGAAGCGGAAGCAGATCAGCGTGCGCGGCCTGGCG
GGGCTAGGCGACGTGGCCGAGGTGCGGAAGAGCTTCAACCGGCACTTGCACTTCACGCTG
GTCAAGGACCGCAATGTGGCCACGCCCCGCGACTACTTCTTCGCGCTGGCGCACACGGTG
CGCGACCACCTCGTGGGCCGCTGGATCCGCACGCAGCAGCACTACTACGAGCGCGACCCC
AAGCGAATTTATTATCTTTCCCTGGAATTCTACATGGGTCGCACGCTGCAGAACACGATG
GTGAACCTGGGCCTTCAGAATGCCTGCGATGAAGCCATCTATCAGTTGGGGTTAGACTTG
GAGGAACTCGAGGAGATAGAAGAAGATGCTGGCCTTGGGAATGGAGGCCTGGGGAGGCTG
GCAGCGTGTTTCCTTGACTCAATGGCTACCTTGGGCCTGGCAGCATACGGCTATGGAATC
CGCTATGAATTTGGGATTTTTAACCAGAAGATTGTCAATGGCTGGCAGGTAGAGGAGGCC
GATGACTGGCTGCGCTACGGCAACCCCTGGGAGAAAGCGCGGCCTGAGTATATGCTTCCC
GTGCACTTCTACGGACGCGTGGAGCACACCCCCGACGGCGTGAAGTGGCTGGACACACAG
GTGGTGCTGGCCATGCCCTACGACACCCCAGTGCCCGGCTACAAGAACAACACCGTCAAC
ACCATGCGGCTGTGGTCCGCAAGGGCTCCCAACGACTTCAAGCTGCAGGACTTCAACGTG
GGAGACTACATCGAGGCGGTCCTGGACCGGAACTTGGCTGAGAACATCTCCAGGGTCCTG
TATCCAAATGATAACTTCTTTGAGGGGAAGGAGCTGCGGCTGAAGCAGGAGTACTTCGTG
GTGGGCGCCACGCTCCAGGACATCATCCGCCGCTTCAAGTCGTCCAAGTTCGGCTGCCGG
GACCCTGTGAGAACCTGTTTCGAGACGTTCCCAGACAAGGTGGCCATCCAGCTGAACGAC
ACCCACCCCGCCCTCTCCATCCCTGAGCTCATGCGGATCCTGGTGGACGTGGAGAAGGTG
GACTGGGACAAGGCCTGGGAAATCACGAAGAAGACCTGTGCATACACCAACCACACTGTG
CTGCCTGAGGCCTTGGAGCGCTGGCCCGTGTCCATGTTTGAGAAGCTGCTGCCGCGGCAC
CTGGAGATAATCTATGCCATCAACCAGCGGCACCTGGACCACGTGGCCGCGCTGTTTCCC
GGCGATGTGGACCGCCTGCGCAGGATGTCTGTGATCGAGGAGGGGGACTGCAAGCGGATC
AACATGGCCCACCTGTGTGTGATTGGGTCCCATGCTGTCAATGGTGTGGCGAGGATCCAC
TCGGAGATCGTGAAACAGTCGGTCTTTAAGGATTTTTATGAACTGGAGCCAGAGAAGTTC
CAGAATAAGACCAATGGCATCACCCCCCGCCGGTGGCTGCTGCTGTGCAACCCGGGGCTG
GCCGATACCATCGTGGAGAAAATTGGGGAGGAGTTCCTGACTGACCTGAGCCAGCTGAAG
AAGCTGCTGCCGCTGGTCAGTGACGAGGTGTTCATCAGGGACGTGGCCAAGGTCAAACAG
GAGAACAAGCTCAAGTTCTCGGCCTTCCTGGAGAAGGAGTACAAGGTGAAGATCAACCCC
TCCTCCATGTTCGATGTGCATGTGAAGAGGATCCACGAGTACAAGCGGCAGCTGCTCAAC
TGCCTGCACGTCGTCACCCTGTACAATCGAATCAAGAGAGACCCGGCCAAGGCTTTTGTG
CCCAGGACTGTTATGATTGGGGGCAAGGCAGCGCCCGGTTACCACATGGCCAAGCTGATC
ATCAAGTTGGTCACCTCCATCGGCGACGTCGTCAATCATGACCCAGTTGTGGGTGACAGG
TTGAAAGTGATCTTCCTGGAGAACTACCGTGTGTCCTTGGCTGAGAAAGTGATCCCGGCC
GCTGATCTGTCGCAGCAGATCTCCACTGCAGGCACCGAGGCCTCAGGCACAGGCAACATG
AAGTTCATGCTCAACGGGGCCCTCACCATCGGCACCATGGACGGCGCCAACGTGGAGATG
GCCGAGGAGGCCGGGGCCGAGAACCTCTTCATCTTCGGCCTGCGGGTGGAGGATGTCGAG
GCCTTGGACCGGAAAGGGTACAATGCCAGGGAGTACTACGACCACCTGCCCGAGCTGAAG
CAGGCCGTGGACCAGATCAGCAGTGGCTTTTTTTCTCCCAAGGAGCCAGACTGCTTCAAG
GACATCGTGAACATGCTGATGCACCATGACAGGTTCAAGGTGTTTGCAGACTATGAAGCC
TACATGCAGTGCCAGGCACAGGTGGACCAGCTGTACCGGAACCCCAAGGAGTGGACCAAG
AAGGTCATCAGGAACATCGCCTGCTCGGGCAAGTTCTCCAGTGACCGGACCATCACGGAG
TATGCACGGGAGATCTGGGGTGTGGAGCCCTCCGACCTGCAGCTTCAGCACCTGCCCCAC
CCAGAGTGGGAGTCAGGTGGAGCCACCTGCTGGGCTCCCCCAGAACTTTGCACACATCTT
GCTATGTATTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
J03544

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_1_Locus:
20p11.2-p11.1

# Metabolic_Enzyme_1_SNPs:
rs2227891; rs2228976; rs2227892; rs2227890; rs2228977; rs16987612; rs6515626; rs6050486; rs2261720; rs2257808; rs2261109; rs910996; rs2424698; rs6050510; rs2261785; rs2424699; rs2257233; rs2261794; rs2257705; rs2261115; rs2261698; rs2257809; rs2281562; rs2257464; rs2261784; rs2260997; rs2474772; rs2257461; rs2424700; rs2261795; rs7269045; rs6050512; rs2261790; rs2261753; rs2261747; rs2257712; rs2474769; rs2257370; rs6050511; rs6037075; rs1555329; rs2258052; rs6115107; rs2281558; rs3787078; rs2258053; rs2145125; rs2258201; rs6107024; rs11697384; rs6115109; rs2257991; rs8118763; rs753009; rs910997; rs1555331; rs6107023; rs6115118; rs2258563; rs6050509; rs6050502; rs6037070; rs4813555; rs7273544; rs6115115; rs2257432; rs6115101; rs2281559; rs8184820; rs2474767; rs3787082; rs2424704; rs8116542; rs6050487; rs2424701; rs3787081; rs6138555; rs3787080; rs1555330; rs8124539; rs8114792; rs2500411; rs2258135; rs2474777; rs6115117; rs2257982; rs8120601; rs6115114; rs6107017; rs2474763; rs12624460; rs2257988; rs11087508; rs2474770; rs6037071; rs13038092; rs2500410; rs6050513; rs11087511; rs6132824; rs2474773; rs2424703; rs6050501; rs2387734; rs11699953; rs6076328; rs6050488; rs12624693; rs2145126; rs12625357; rs12625045; rs2474766; rs11697736; rs6107021; rs6132825; rs6115121; rs2500413; rs7274919; rs6037069; rs6115106; rs3002702; rs2474762; rs2257649; rs8115188; rs2180597; rs6115116; rs6050515; rs4815398; rs2257985; rs12624472; rs8125980; rs6107022; rs6107019; rs2258066; rs2258617; rs2273473; rs6138553; rs7274104; rs6132822; rs11549036; rs6037077; rs6115125; rs6115124; rs35481467; rs6050484; rs35073849; rs2228978; rs6115120; rs35669741; rs35189278; rs6083789; rs2474764; rs11474310; rs34233544; rs4619688; rs34170256; rs11483996; rs34871259; rs12625447; rs7272247; rs11472555; rs6083794; rs6115113; rs6115108; rs8125437; rs6050485; rs11472504; rs11471241; rs35760653; rs2254046; rs3838000; rs6050503; rs7274130; rs11473890; rs6050520; rs6083790; rs6050507; rs2180596; rs6115102; rs10582106; rs6115129; rs6037079; rs7353137; rs11466827; rs6050493; rs2474774; rs6050491; rs6107018; rs35358504; rs11468635; rs11468776; rs13043218; rs34067778; rs34827380; rs11475816; rs41282330; rs6138556; rs5841050; rs34496209; rs6050498; rs13043643; rs34360139; rs35375864; rs13044624; rs6107020; rs6138551; rs11699652; rs2474776; rs6115123; rs2474768; rs6050508; rs11312793; rs35716293; rs6115104; rs35058859; rs36105797; rs6050494; rs13433150; rs11470476; rs34346429; rs6050492; rs11471520; rs6115128; rs6115103; rs12106151; rs2983489; rs6050504; rs11468520; rs6083788; rs41282328; rs6050490; rs11087510; rs28770021; rs35286896; rs4364079; rs6050521; rs11475085; rs6138558; rs6037068; rs7352961; rs11480235; rs33973694; rs7269584; rs6115130; rs2983490; rs11350552; rs6115110; rs5841051; rs35988788; rs35243193; rs2281561; rs6050495; rs6138552; rs6076330; rs35609563; rs12626048; rs7363911; rs6083793; rs6115122; rs34299454; rs6115105; rs34646441; rs2474775; rs35264724; rs33964550; rs6050505; rs12625048; rs2474771; rs11477346; rs2500426; rs6050522; rs6050519; rs34336965; rs6138559; rs8114789; rs36117882; rs11470854; rs35760227; rs3841696; rs5841052; rs13433144; rs2281560; rs6050523; rs1118963; rs33999482; rs35370770; rs34672197; rs13038488; rs35258354; rs34316192; rs34427422; rs35256912; rs11479739; rs6037073; rs13043662; rs3787079; rs34204571; rs6083791; rs6115111; rs11908154; rs34776023; rs7272959; rs1077889; rs28881233; rs6083792; rs11480711; rs6138554; rs13037005; rs2474765; rs35263526; rs6050483; rs34955390; rs1046073; rs10966; rs1130694; rs11905042; rs2258719; rs2258769; rs2259873; rs2260197; rs2261796; rs2474779; rs2474780; rs6050471; rs6050473; rs6050475; rs6050476; rs6050477; rs6050481; rs6107016; rs6107027; rs6115098; rs6115100; rs7019; rs7344105; rs746748; rs8119343; rs9927

# Metabolic_Enzyme_1_General_References:
3346228; 2615594; 11780052; 12665801

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5610

# Metabolic_Enzyme_2_Name:
Glycogen phosphorylase, muscle form

# Metabolic_Enzyme_2_Synonyms:
Myophosphorylase

# Metabolic_Enzyme_2_Gene_Name:
PYGM

# Metabolic_Enzyme_2_Protein_Sequence:
>Glycogen phosphorylase, muscle form
MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTV
RDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDM
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEA
DDWLRYGNPWEKARPEFTLPVHFYGHVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVN
TMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERM
DWDKAWDVTVRTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFP
GDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKF
QNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLDQLRKLLSFVDDEAFIRDVAKVKQ
ENKLKFAAYLEREYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKREPNKFFV
PRTVMIGGKAAPGYHMAKMIIRLVTAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPA
ADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVD
KLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYED
YIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE
AI

# Metabolic_Enzyme_2_Number_of_Residues:
842

# Metabolic_Enzyme_2_Molecular_Weight:
97093

# Metabolic_Enzyme_2_Theoretical_pI:
7.03

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
Function:  phosphorylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

# Metabolic_Enzyme_2_Pathway:
map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_2_Reaction:
(1,4-alpha-D-glucosyl)n + phosphate = (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00343:Phosphorylase

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.4.1.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
190784

# Metabolic_Enzyme_2_SwissProt_ID:
PYGM_HUMAN (P11217)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
PYGM

# Metabolic_Enzyme_2_Geneatlas_id:
PYGM

# Metabolic_Enzyme_2_hgnc_id:
HGNC:9726

# Metabolic_Enzyme_2_PDB_ID:
1XL1

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>2529 bp
ATGTCCCGGCCCCTGTCAGACCAAGAGAAAAGAAAGCAAATCAGTGTGCGTGGCCTGGCC
GGCGTGGAGAACGTGACTGAGCTGAAAAAGAACTTCAACCGGCACCTGCATTTCACACTC
GTAAAGGACCGCAATGTGGCCACCCCACGAGACTACTACTTTGCTCTGGCCCATACCGTG
CGCGACCACCTCGTGGGGCGGTGGATCCGCACGCAGCAGCACTACTATGAGAAGGACCCC
AAGAGGATCTACTACCTGTCTTTAGAGTTCTATATGGGACGGACGCTACAGAACACCATG
GTGAACCTGGCCTTAGAGAATGCCTGTGACGAGGCCACCTACCAGCTGGGCCTGGACATG
GAGGAGCTGGAGGAAATTGAGGAGGATGCGGGGCTGGGCAACGGGGGCCTGGGCCGGCTG
GCAGCCTGCTTTCTTGACTCCATGGCAACACTGGGCCTGGCTGCCTATGGCTACGGGATT
CGCTATGAGTTTGGGATTTTTAACCAGAAGATCTCCGGGGGCTGGCAGATGGAGGAGGCC
GATGACTGGCTTCGCTACGGCAACCCCTGGGAGAAGGCCCGGCCCGAGTTCACGCTACCT
GTGCACTTCTACGGCCATGTGGAGCACACCAGCCAGGGTGCCAAGTGGGTGGACACACAG
GTGGTACTGGCCATGCCCTACGATACCCCGGTGCCTGGCTATCGCAACAATGTTGTCAAC
ACCATGCGCCTCTGGTCTGCCAAGGCTCCCAATGACTTCAACCTCAAGGACTTCAATGTC
GGTGGCTACATCCAGGCTGTGTTGGACCGAAACCTGGCGGAGAACATCTCTCGTGTCCTG
TACCCCAATGATAATTTCTTCGAAGGGAAGGAGCTGCGGCTGAAGCAGGAGTATTTCGTG
GTGGCTGCCACCCTCCAGGACATCATCCGTCGCTTCAAGTCTTCCAAGTTCGGCTGCCGT
GATCCCGTGCGCACGAACTTCGATGCCTTCCCAGATAAGGTGGCCATCCAGCTCAATGAC
ACCCACCCCTCCCTGGCCATCCCCGAGCTGATGAGGATCCTGGTGGACCTGGAACGGATG
GACTGGGACAAGGCGTGGGATGTGACAGTGAGGACCTGTGCCTACACCAACCACACGGTG
CTGCCCGAGGCCCTGGAGCGCTGGCCGGTGCACCTCTTGGAGACGCTGCTGCCGCGGCAC
CTCCAGATCATCTACGAGATCAACCAGCGCTTCCTCAACCGGGTGGCGGCCGCATTCCCA
GGGGACGTAGACCGGCTGCGGCGCATGTCGCTGGTGGAGGAGGGCGCAGTGAAGCGCATC
AACATGGCACACCTGTGCATCGCGGGGTCGCACGCCGTCAACGGTGTGGCCCGCATCCAC
TCGGAGATCCTCAAGAAGACCATCTTCAAAGACTTCTATGAGCTGGAGCCTCATAAGTTC
CAGAATAAGACCAACGGCATCACCCCTCGGCGCTGGCTGGTTCTGTGTAACCCCGGGCTG
GCAGAGGTCATTGCTGAGCGCATCGGGGAGGACTTCATCTCTGACCTGGACCAGCTGCGC
AAACTGCTCTCCTTTGTGGATGATGAAGCTTTCATTCGGGATGTGGCCAAAGTGAAGCAG
GAAAACAAGTTGAAGTTTGCTGCCTACCTAGAGAGGGAATACAAAGTCCACATCAACCCC
AACTCACTCTTCGACATCCAGGTGAAGCGGATTCACGAATATAAACGACAGCTCCTCAAC
TGCCTCCATGTCATCACCCTGTACAACCGCATCAAGAGGGAGCCCAATAAGTTTTTTGTG
CCTCGGACTGTGATGATTGGAGGGAAGGCTGCACCTGGGTACCACATGGCCAAGATGATC
ATCAGACTCGTCACAGCCATCGGGGATGTGGTCAACCATGACCCGGCAGTGGGTGACCGC
CTCCGTGTCATCTTCCTGGAGAACTACCGAGTCTCACTGGCCGAGAAAGTGATCCCAGCT
GCAGACCTCTCTGAGCAGATCTCCACTGCGGGCACTGAAGCCTCAGGCACCGGCAACATG
AAGTTCATGCTCAACGGGGCTCTGACCATTGGCACCATGGACGGGGCCAATGTGGAGATG
GCAGAAGAGGCGGGAGAGGAAAACTTCTTCATCTTTGGCATGCGGGTGGAGGATGTGGAT
AAGCTTGACCAAAGAGGGTACAATGCCCAGGAGTACTACGATCGCATTCCTGAGCTTCGG
CAGGTCATTGAGCAGCTGAGCAGTGGCTTCTTCTCCCCCAAACAACCCGACCTGTTCAAG
GACATTGTCAATATGCTCATGCACCATGACCGGTTTAAAGTCTTCGCAGATTATGAAGAC
TACATTAAATGCCAGGAGAAAGTCAGCGCCTGGTACAAGAACCCAAGAGAGTGGACGCGG
ATGGTGATCCGGAACATAGCCACTTCTGGCAAGTTCTCCAGTGACCGCACCATTGCCCAG
TATGCCCGGGAGATCTGGGGTGTGGAGCCTTCCCGCCAGCGCCTGCCAGCCCCGGATGAG
GCCATCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M32598

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_2_Locus:
11q12-q13.2

# Metabolic_Enzyme_2_SNPs:
rs483962; rs489192; rs686171; rs547066; rs477549; rs565688; rs490980; rs7938455; rs592521; rs589691; rs625172; rs592532; rs506354; rs532747; rs592546; rs474006; rs7126110; rs2959652; rs566653; rs630966; rs637332; rs11821081; rs604595; rs11231866; rs2230309; rs1212604; rs11231865; rs1056780; rs28940587; rs669572; rs12278323; rs9704315; rs34267133; rs3202054; rs576632; rs34991365; rs2071320; rs34447097; rs34154523; rs608261; rs28398896; rs1207113; rs550545; rs555974; rs7114931; rs569200; rs608257; rs7104895; rs34195091; rs35447888; rs34978393; rs2071318; rs11308610; rs12364023; rs2284302; rs34338262; rs35958437; rs35091627; rs35071540; rs1803954; rs1804549; rs2073797; rs2073798; rs2277308; rs2277309; rs2301563; rs2904961; rs2959650; rs3168088; rs3759049; rs3759051; rs3759052; rs3891505; rs484886; rs523200; rs546323; rs547280; rs550930; rs561158; rs588139; rs610637; rs620006; rs637732; rs681791

# Metabolic_Enzyme_2_General_References:
3447177; 3840433; 3466902; 8316268; 8535454; 7603523; 9506549; 10417800; 10382911; 10382912; 10681080; 10590419; 10714589; 10899452; 11706962; 12031624

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5565

# Metabolic_Enzyme_3_Name:
GDH/6PGL endoplasmic bifunctional protein precursor [Includes: Glucose 1-dehydrogenase

# Metabolic_Enzyme_3_Synonyms:
Hexose-6-phosphate dehydrogenase; 6- phosphogluconolactonase; 6PGL]

# Metabolic_Enzyme_3_Gene_Name:
H6PD

# Metabolic_Enzyme_3_Protein_Sequence:
>GDH/6PGL endoplasmic bifunctional protein precursor Includes: Glucose 1dehydrogenase
MWNMLIVAMCLALLGCLQAQELQGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGRGHSF
SFHGAALTAPKQGQELMAKALESLSCPKDMAPSHCAEHKDQFLQLSQYRQLKTAEDYQAL
NKDIEAQLQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDH
FSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDGLWNRHHVERVEII
MKETVDAEGRTSFYEEYGVIRDVLQNHLTEVLTLVAMELPHNVSSAEAVLRHKLQVFQAL
RGLQRGSAVVGQYQSYSEQVRRELQKPDSFHSLTPTFAAVLVHIDNLRWEGVPFILMSGK
ALDERVGYARILFKNQACCVQSEKHWAAAQSQCLPRQLVFHIGHGDLGSPAVLVSRNLFR
PSLPSSWKEMEGPPGLRLFGSPLSDYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLL
ASWNFWTPLLESLAHKAPRLYPGGAENGRLLDFEFSSGRLFFSQQQPEQLVPGPGPAPMP
SDFQVLRAKYRESPLVSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQ
QLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHLLQHVRIPYYNIHPMPVHLQQ
RLCAEEDQGAQIYAREISALVANSSFDLVLLGMGADGHTASLFPQSPTGLDGEQLVVLTT
SPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLPHSGQL
VWYMDYDAFLG

# Metabolic_Enzyme_3_Number_of_Residues:
791

# Metabolic_Enzyme_3_Molecular_Weight:
88894

# Metabolic_Enzyme_3_Theoretical_pI:
7.31

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  6-phosphogluconolactonase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  glucose-6-phosphate 1-dehydrogenase activity
 ||
>>>
Process:  glucose catabolism
Process:  pentose-phosphate shunt
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates

# Metabolic_Enzyme_3_Pathway:
map00030  Pentose phosphate pathway

# Metabolic_Enzyme_3_Reaction:
6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF02781:G6PD_C;
PF00479:G6PD_N;
PF01182:Glucosamine_iso

# Metabolic_Enzyme_3_Signals:
1-19

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.1.1.47;EC 3.1.1.31

# Metabolic_Enzyme_3_GenBank_ID_Protein:
4186038

# Metabolic_Enzyme_3_SwissProt_ID:
G6PE_HUMAN (O95479)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
H6PD

# Metabolic_Enzyme_3_Geneatlas_id:
H6PD

# Metabolic_Enzyme_3_hgnc_id:
HGNC:4795

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum lumen. Note=Microsomes, endoplasmic reticulum lumen

# Metabolic_Enzyme_3_Gene_Sequence:
>2376 bp
ATGTGGAATATGCTCATAGTGGCGATGTGCTTGGCCCTTCTGGGCTGCCTGCAAGCCCAG
GAGCTCCAGGGACATGTCTCCATAATCCTGCTGGGAGCAACTGGGGACCTGGCTAAGAAG
TACTTATGGCAGGGACTGTTCCAGCTGTACCTGGATGAAGCGGGGAGGGGTCACAGTTTT
AGCTTCCATGGAGCTGCTCTGACAGCCCCCAAGCAGGGTCAAGAGCTCATGGCCAAGGCC
CTGGAATCCCTCTCCTGCCCCAAGGACATGGCACCCAGTCACTGTGCAGAGCACAAGGAT
CAGTTCCTGCAGCTGAGCCAGTACCGCCAACTGAAGACGGCCGAGGACTATCAGGCCCTG
AACAAGGACATCGAGGCACAGCTCCAGCACGCAGGCCTCCGGGAGGCTGGCAGGATCTTC
TACTTCTCAGTGCCACCCTTCGCCTATGAAGACATTGCCCGCAACATCAACAGTAGCTGC
CGGCCAGGCCCGGGCGCCTGGCTGCGGGTTGTCCTTGAGAAACCCTTTGGCCATGACCAC
TTCTCAGCCCAGCAGCTGGCCACAGAACTCGGGACCTTTTTCCAGGAGGAGGAGATGTAC
CGGGTGGACCATTACTTAGGCAAGCAGGCTGTGGCGCAGATCCTGCCTTTCCGAGACCAG
AACCGCAAGGCTTTGGACGGCCTCTGGAACCGGCACCATGTGGAGCGGGTGGAGATCATC
ATGAAAGAGACCGTGGATGCTGAAGGCCGCACCAGCTTCTATGAGGAGTACGGTGTCATT
CGCGACGTCCTCCAGAACCATCTGACGGAGGTCCTCACCCTCGTGGCCATGGAGCTGCCC
CACAATGTCAGCAGTGCGGAGGCTGTGCTGCGGCACAAGCTTCAGGTCTTCCAGGCGCTG
CGGGGCCTGCAGAGGGGCAGTGCCGTCGTGGGCCAGTACCAGTCTTACAGTGAGCAGGTG
CGCAGAGAGCTGCAGAAGCCAGACAGCTTCCACAGCCTGACGCCGACCTTCGCAGGTGTC
CTAGTGCACATTGACAACCTTCGCTGGGAGGGCGTGCCTTTCATCCTGATGTCTGGCAAA
GCCTTGGACGAGAGAGTGGGCTACGCTCGGATCTTGTTCAAGAACCAGGCCTGCTGTGTG
CAGAGCGAAAAGCACTGGGCCGCGGCGCAGAGCCAGTGCCTGCCCCGGCAGCTCGTCTTC
CACATCGGCCATGGCGACCTGGGCAGCCCTGCCGTGCTGGTCAGCAGGAACCTGTTCAGG
CCCTCCCTGCCCTCCAGCTGGAAGGAAATGGAGGGACCACCTGGGCTCCGCCTTTTCGGC
AGCCCTCTGTCCGATTACTACGCCTACAGCCCTGTGCGGGAGCGGGACGCCCACTCCGTC
CTCTTATCCCATATCTTCCATGGCCGGAAGAATTTCTTCATCACCACAGAGAACTTGCTG
GCCTCCTGGAACTTCTGGACCCCTCTGCTGGAGAGCCTGGCCCATAAGGCCCCACGCCTC
TACCCTGGAGGAGCTGAGAATGGCCGTCTGTTGGACTTTGAGTTCAGTAGCGGCCGGTTG
TTCTTTTCCCAGCAGCAGCCGGAGCAGCTGGTGCCAGGGCCAGGGCCGGCCCCAATGCCC
AGTGACTTCCAGGTCCTCAGGGCCAAGTACCGAGAGAGCCCGCTGGTCTCCGCCTGGTCC
GAGGAGCTGATCTCTAAGCTGGCTAATGACATCGAGGCCACCGCTGTGCGAGCCGTGCGG
CGCTTTGGCCAGTTCCACCTGGCACTGTCGGGGGGCTCGAGCCCCGTGGCCCTGTTCCAG
CAGCTGGCCACGGCGCACTATGGCTTCCCCTGGGCCCACACGCACCTGTGGCTGGTTGAC
GAGCGCTGCGTCCCACTCTCAGACCCGGAGTCCAACTTCCAGGGCCTGCAGGCCCACCTG
CTGCAGCACGTCCGGATCCCCTACTACAACATCCACCCCATGCCTGTGCACCTGCAGCAG
CGGCTCTGCGCCGAGGAGGACCAGGGCGCCCAGATCTATGCCAGGGAGATCTCAGCCCTG
GTGGCCAACAGCAGCTTCGACCTGGTGCTGCTGGGCATGGGTGCCGACGGGCACACAGCC
TCCCTCTTCCCACAGTCACCCACTGGCCTGGATGGCGAGCAGCTGGTCGTGCTGACCACG
AGCCCCTCCCAGCCACACCGCCGCATGAGCCTTAGCCTGCCTCTCATCAACCGCGCCAAG
AAGGTGGCAGTCCTGGTCATGGGCAGGATGAAGCGTGAGATCACCACGCTGGTGAGCCGG
GTGGGCCATGAGCCCAAGAAGTGGCCCATCTCGGGTGTCCTGCCGCACTCCGGCCAGCTG
GTGTGGTACATGGACTACGACGCCTTCCTGGGATGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
AJ012590

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_3_Locus:
1p36

# Metabolic_Enzyme_3_SNPs:
rs6688832; rs17368528; rs35404275; rs34603401; rs35525021; rs7524046; rs9434743; rs9434742; rs11121350; rs35301166; rs1294014; rs11807816; rs2268175; rs12314; rs1294015; rs2239561; rs2268176; rs11121354; rs11121356; rs17368633; rs11121355; rs2268173; rs2071931; rs9434747; rs17033642; rs1142687; rs11121349; rs12405956; rs6685399; rs4908830; rs1294011; rs9434745; rs9435159; rs9434729; rs12126056; rs2268172; rs11588606; rs1142672; rs2239560; rs732950; rs731183; rs3753165; rs1294010; rs3753164; rs2268169; rs3753163; rs2268170; rs6662509; rs11804534; rs763180; rs11809790; rs2310925; rs10864404; rs2311051; rs11806000; rs3765959; rs10864403; rs12082862; rs7526864; rs9435151; rs7514387; rs6577564; rs11801562; rs9434725; rs7522207; rs35610691; rs34274595; rs12118991; rs35668164; rs17368556; rs35511555; rs34580447; rs35863691; rs7412488; rs36094664; rs34082738; rs34448374; rs36058755; rs3207298; rs33954071; rs3207317; rs3752547; rs5772361; rs41280760; rs9434726; rs35833857; rs12728837; rs4908831; rs1065216; rs3207316; rs3057978; rs11588618; rs35071335; rs41280764; rs9435162; rs2268174; rs9435144; rs35341128; rs34967254; rs9435148; rs34715803; rs1142686; rs1142671; rs9435161; rs1138467; rs12144045; rs34078161; rs12403063; rs1138468; rs1142675; rs35486518; rs3206225; rs1142689; rs9435163; rs6697931; rs1294016; rs35600947; rs9434746; rs41280762; rs2268171; rs6658895; rs12040818; rs1142688; rs9435164; rs1142690; rs34854341; rs9434737; rs36065021; rs1294009; rs5772359; rs12039626; rs9435158; rs1890684; rs34931714; rs12076525; rs2097519; rs763179; rs28548609; rs28665681; rs34308839; rs12083129; rs10449320; rs3861753; rs9434736; rs12032814; rs11805951; rs9435152; rs34764359; rs28496367; rs35492379; rs9435156; rs9434732; rs11804519; rs3765958; rs5772358; rs9435155; rs12042692; rs9434738; rs743972; rs35063052; rs12039625; rs2185298; rs12738271; rs2095907; rs4601607; rs34149245; rs6680990; rs9435167; rs9435166; rs7523498; rs35587892; rs7523400; rs1003369; rs1004920; rs10489436; rs10746487; rs11590326; rs12072683; rs12093524; rs12093571; rs12403829; rs1294012; rs2097520; rs2105225; rs2871656; rs34870859; rs3753271; rs4908832; rs6688233; rs7517538; rs916379; rs916380; rs916381; rs916382; rs916383; rs916384; rs916385; rs916386; rs9434723; rs9435168; rs9435179; rs946599; rs946602

# Metabolic_Enzyme_3_General_References:
10349511

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5606

# Metabolic_Enzyme_4_Name:
Glycogen phosphorylase, liver form

# Metabolic_Enzyme_4_Synonyms:
Not Available

# Metabolic_Enzyme_4_Gene_Name:
PYGL

# Metabolic_Enzyme_4_Protein_Sequence:
>Glycogen phosphorylase, liver form
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTV
RDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEA
DDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN
TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL
PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP
KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF
QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQ
ENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV
PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPA
TDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA
ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA
YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE
SNKVNGN

# Metabolic_Enzyme_4_Number_of_Residues:
847

# Metabolic_Enzyme_4_Molecular_Weight:
97150

# Metabolic_Enzyme_4_Theoretical_pI:
7.17

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
Function:  phosphorylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

# Metabolic_Enzyme_4_Pathway:
map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_4_Reaction:
(1,4-alpha-D-glucosyl)n + phosphate = (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00343:Phosphorylase

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.4.1.1

# Metabolic_Enzyme_4_GenBank_ID_Protein:
183353

# Metabolic_Enzyme_4_SwissProt_ID:
PYGL_HUMAN (P06737)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
PYGL

# Metabolic_Enzyme_4_Geneatlas_id:
PYGL

# Metabolic_Enzyme_4_hgnc_id:
HGNC:9725

# Metabolic_Enzyme_4_PDB_ID:
1L7X

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>2544 bp
ATGGGCGAACCGCTGACAGACCAGGAGAAGCGGCGGCAGATCAGCATCCGCGGCATCGTG
GGCGTGGAGAACGTGGCAGAGCTGAAGAAGAGTTTCAACCGGCACCTGCACTTCACGCTG
GTCAAGGACCGCAACGTGGCCACCACCCGCGACTACTACTTCGCGCTGGCGCACACGGTG
CGGGACCACCTGGTGGGGCGCTGGATCCGCACGCAGCAGCACTACTACGACAAGTGCCCC
AAGAGGGAATATTACCTCTCTCTGGAATTTTACATGGGCCGAACATTACAGAACACCATG
ATCAACCTCGGTCTGCAAAATGCCTGTGATGAGGCCATTTACCAGCTTGGATTGGATATA
GAAGAGTTAGAAGAAATTGAAGAAGATGCTGGACTTGGCAATGGTGGTCTTGGGAGACTT
GCTGCCTGCTTCTTGGATTCCATGGCAACCCTGGGACTTGCAGCCTATGGATACGGCATT
CGGTATGAATATGGGATTTTCAATCAGAAGATCCGAGATGGATGGCAGGTAGAAGAAGCA
GATGATTGGCTCAGATATGGAAACCCTTGGGAGAAGTCCCGCCCAGAATTCATGCTGCCT
GTGCACTTCTATGGAAAAGTAGAACACACCAACACCGGGACCAAGTGGATTGACACTCAA
GTGGTCCTGGCTCTGCCATATGACACCCCCGAGCCCGGCTACATGAATAACACTGTCAAC
ACCATGCGCCTCTGGTCTGCTCGGGCACCAAATGACTTTAACCTCAGAGACTTTAATGTT
GGAGACTACATTCAGGCTGTGCTGGACCGAAACCTGGCCGAGAACATCTCCCGGGTCCTC
TATCCCAATGACAATTTTTTTGAAGGGAAGGAGCTAAGATTGAAGCAGGAATACTTTGTG
GTGGCTGCAACCTTGCAAGATATCATCCGCCGTTTCAAAGCCTCCAAGTTTGGCTCCACC
CGTGGTCAAGGAACTGTGTTTGATGCCTTCCCGGATCAGGTGGCCATCCAGCTGAATGAT
ACTCACCCTCGCATCGCGATCCCTGAGCTGATGAGGATTTTTGTGGATATTGAAAAACTG
CCCTGGTCCAAGGCATGGGAGCTCAACCAGAAGACCTTCGCCTACACCAACCACACAGTG
CTCCCGGAAGCCCTGGAGCGCTGGCCCGTGGACCTGGTGGAGAAGCTGCTCCCTCGACAT
TTGGAAATCATTTATGAGATAAATCAGAAGCATTTAGATAGAATTGTGGCCTTGTTTCCT
AAAGATGTGGACCCTCTGAGAAGGATGTCTCTGATAGAAGAGGAAGGAAGCAAAAGGATC
AACATGGCCCATCTCTGCATTGTCGGTTCCCATGCTGTGAATGGCGTGGCTAAAATCCAC
TCAGACATCGTGAAGACTAAAGTATTCAAGGACTTCAGTGAGCTAGAACCTGACAAGTTT
CAGAATAAAACCAATGGGATCACTCCAAGGCGCTGGCTCCTACTCTGCAACCCAGGACTT
GCAGAGCTCATAGCAGAGAAAATTGGAGAAGACTATGTGAAAGACCTGAGCCAGCTGACG
AAGCTCCACAGCTTCCTGGGTGATGATGTCTTCCTCCGGGAACTCGCCAAGGTGAAGCAG
GAGAATAAGCTGAAGTTTTCTCAGTTCCTGGAGACGGAGTACAAAGTGAAGATCAACCCA
TCCTCCATGTTTGATGTCCAGGTGAAGAGGATACATGAGTACAAGCGACAGCTCTTGAAC
TGTCTGCATGTGATCACGATGTACAACCGCATTAAGAAAGACCCTAAGAAGTTATTCGTG
CCAAGGACAGTTATCATTGGTGGTAAAGCTGCCCCAGGATATCACATGGCCAAAATGATC
ATAAAGCTGATCACTTCAGTGGCAGATGTGGTGAACAATGACCCTATGGTTGGAAGCAAG
TTGAAAGTCATCTTCTTGGAGAACTACAGAGTATCTCTTGCTGAAAAAGTCATTCCAGCC
ACAGATCTGTCAGAGCAGATTTCCACTGCAGGCACCGAAGCCTCGGGGACAGGCAATATG
AAGTTCATGCTAAATGGGGCCCTAACTATCGGGACCATGGATGGGGCCAATGTGGAAATG
GCAGAAGAAGCTGGGGAAGAGAACCTGTTCATCTTTGGCATGAGCATAGATGATGTGGCT
GCTTTGGACAAGAAAGGGTACGAGGCAAAAGAATACTATGAGGCACTTCCAGAGCTGAAG
CTGGTCATTGATCAAATTGACAATGGCTTTTTTTCTCCCAAGCAGCCTGACCTCTTCAAA
GATATCATCAACATGCTATTTTATCATGACAGGTTTAAAGTCTTTGCAGACTACGAAGCC
TATGTCAAGTGTCAAGATAAAGTGAGTCAGCTGTACATGAATCCAAAGGCCTGGAACACA
ATGGTACTCAAAAACATAGCTGCCTCGGGGAAATTCTCCAGTGACCGAACAATTAAAGAA
TATGCCCAAAACATCTGGAACGTGGAACCTTCAGATCTAAAGATTTCTCTATCCAATGAA
TCTAACAAAGTCAATGGAAATTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M14636

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_4_Locus:
14q21-q22

# Metabolic_Enzyme_4_SNPs:
rs946616; rs2228499; rs35831273; rs34313873; rs2275465; rs17123244; rs1042193; rs2027342; rs2277456; rs1959527; rs2356729; rs1890706; rs1953875; rs946618; rs946617; rs1890705; rs883699; rs1890707; rs8004768; rs10143053; rs11157783; rs2275464; rs6572712; rs7160537; rs2075646; rs6572710; rs10132049; rs3825542; rs11852047; rs3783275; rs11846565; rs8021270; rs11846180; rs8022952; rs2027341; rs1953872; rs10149867; rs11851644; rs3783273; rs3825541; rs2356535; rs3783274; rs8004788; rs11851482; rs17123189; rs11851115; rs8014291; rs2275466; rs7142143; rs12432519; rs11845307; rs7149936; rs17123178; rs1953873; rs10138493; rs10140858; rs3818871; rs8005400; rs17123235; rs11844515; rs11850411; rs3783276; rs7154048; rs8019788; rs12436081; rs12717412; rs10146041; rs8003312; rs8003460; rs882860; rs8022363; rs17123173; rs9635167; rs6572711; rs17123125; rs10142003; rs17123232; rs8005931; rs4901066; rs11845548; rs11623430; rs12878997; rs8008832; rs17123223; rs8006455; rs8019957; rs17123216; rs17123180; rs8020787; rs17123242; rs3783277; rs8019817; rs11849348; rs11851406; rs8009460; rs8019779; rs11846533; rs11850468; rs10130689; rs8020100; rs9635221; rs12887698; rs2297890; rs7159436; rs3759524; rs2297891; rs8005560; rs7159221; rs1126549; rs35026927; rs34096980; rs11541446; rs1042210; rs1042195; rs17721570; rs35110875; rs1042191; rs11356035; rs8018727; rs10539449; rs11420723; rs35650221; rs28419360; rs34660650; rs34764341; rs35154208; rs5808582; rs33962723; rs7157107; rs36014565; rs8021856; rs3837582; rs10140029; rs34040095; rs28584430; rs10146475; rs5808583; rs34267914; rs35765728; rs4540982; rs11849168; rs12888774; rs12881770; rs12882746; rs8006359; rs9788547; rs17123214; rs8009028; rs34052455; rs35565564; rs35049468; rs35657235; rs17123129; rs34648049; rs3783278; rs5808581; rs10145332; rs35116945; rs17123212; rs28497027; rs11308384; rs4027576; rs12882737; rs35955629; rs35236069; rs34707370; rs11351672; rs12887874; rs35638781; rs17123170; rs11414268; rs12881559; rs10674203; rs34456437; rs10133328; rs1890701; rs12882740; rs41317304; rs33993827; rs11846857; rs8005878; rs35069435; rs35098001; rs7141901; rs3082637; rs35620941; rs35195741; rs8016466; rs17123239; rs12882739; rs12879826; rs4898677; rs28540603; rs34592047; rs34351109; rs28407049; rs28707425; rs12880288; rs28759343; rs1005689; rs1042266; rs11157780; rs11157781; rs11157782; rs11847031; rs11847533; rs11850729; rs11850781; rs12431674; rs12431737; rs12434792; rs12589201; rs12589665; rs12880129; rs12889552; rs12891106; rs1538615; rs17123097; rs17123103; rs17123116; rs1890700; rs1890704; rs2075643; rs2075644; rs2075645; rs2185303; rs2356730; rs28564871; rs34204001; rs34240348; rs34800262; rs35501326; rs3759519; rs3759520; rs3759521; rs4901064; rs4901065; rs4901067; rs7154732; rs7159068; rs885375

# Metabolic_Enzyme_4_General_References:
2877458; 9536091; 9529348; 3509980; 10980448; 10949035; 12204691

# Metabolic_Enzyme_4_References:
Not Available

End of HMDB00150

Beginning of HMDB00151
# Accession_No:
HMDB00151

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-09-27 21:02:02

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Estradiol

# Description:
Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the PLACENTA. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (RECEPTORS, ESTROGEN) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized.

# Synonyms:
(+)-3,17b-Estradiol; (17b)-Estra-1,3,5(10)-triene-3,17-diol; 13b-Methyl-1,3,5(10)-gonatriene-3,17b-ol; 17b-Estradiol; 17b-Oestradiol; 3,17-Epidihydroxyestratriene; 3,17b-Dihydroxyestra-1,3,5(10)-triene; 3,17b-Estradiol; Aerodiol; Agofollin; Altrad; Amnestrogen; Aquadiol; Bardiol; Beta-estradiol; Climaderm; Climara; Compudose; Compudose 200; Compudose 365; Corpagen; D-Estradiol; D-Oestradiol; Dermestril; Dihydrofollicular hormone; Dihydrofolliculin; Dihydromenformon; Dihydrotheelin; Dihydroxyestrin; Dimenformon; Diogyn; Diogynets; Divigel; Encore; Epiestriol 50; Estra-1,3,5(10)-triene-3,17b-diol; Estrace; Estradiol; Estradot; Estraldine; Estring Vaginal Ring; Estroclim; Estroclim 50; Estrogel; Estrogel HBF; Estrovite; Evorel; Femestral; Femogen; Follicyclin; Gelestra; Ginosedol; Gynergon; Gynoestryl; Lamdiol; Macrodiol; Menorest; Nordicol; Oesclim; Oestergon; Oestra-1,3,5(10)-triene-3,17b-diol; Oestradiol; Oestrogel; Oestroglandol; Ovahormon; Ovasterol; Ovastevol; Ovocyclin; Ovocylin; Perlatanol; Primofol; Profoliol; Profoliol B; Progynon; Progynon DH; Sandrena 1; Syndiol; Systen; Vivelle; Zumenon; b-Estradiol; dihydro-Theelin; Estraderm TTS; delta-Estradiol; delta-Oestradiol

# Chemical_IUPAC_Name:
13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

# Chemical_Formula:
C18H24O2

# Chemical_Structure:
tbl_chemical:::HMDB00151_ZOOM.png:::119283219960622122

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00151_THUMB.png:::119283219766766346

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Sterols

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
secondary alcohol; phenol or hydroxyhetarene; aromatic compound

# Taxonomy_Biofunction:
Component of Androgen and estrogen metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
272.17764

# Molecular_Weight_Avg:
272.38196

# Smiles_String_isomeric:
C[C@]12CC[C@H]3[C@@H](CCC4=C3C=CC(O)=C4)[C@@H]1CC[C@@H]2O

# Smiles_String_canonical:
CC12CCC3C(CCC4=C3C=CC(O)=C4)C1CCC2O

# KEGG_Compound_ID:
C00951

# BioCyc_ID:
CPD-352

# PubChem_CID:
5757

# PubChem_SID:
8028360; 11367943; 11375407; 818901; 11120771; 11486157; 11110639; 11467589; 4266382; 821147; 822854; 7852065; 819487; 820385; 829421; 7887363; 818964; 11121259; 10321307; 11376105; 823461; 11370869; 831023; 839067; 7847173; 11364683; 831024; 839061; 11377970; 11122188; 8153534; 838509; 841780; 7992950; 148536; 11362819; 823615; 12012600; 11365381; 11372848; 839062; 11370870; 11373544; 11121708; 8139865; 11367245; 11466469; 11369807; 825708; 652955; 8143549; 4202; 75249; 209199; 11120283; 8139856

# OMIM_ID:
Not Available

# Metagene_ID:
AROMATASE DEFICIENCY: 429

# BiGG_ID:
36456

# Wikipedia_ID:
Estradiol

# METLIN_ID:
263

# Ref_ID:
16060908; 7955523; 16155259; 15887853; 16148373; 15542692; 14632858; 16487434; 15811930; 11929836; 10488657; 14561431; 15618333; 8567793; 1777462; 15886248; 16735951; 11703424; 16313478; 15843221

# ChEBI_ID:
16469

# CAS_Registry_Number:
50-28-2

# InChI:
InChI=1/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

# Synthesis_Reference:
 Journal of the American Chemical Society  (1951),  73  847-8.

# Melting_Point:
178.5 oC

# Melting_Point_predicted:
125.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.0036 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
0.0213 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
4.01 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
3.57 [Predicted by ALOGPS]; 4.2 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::b-Estradiol.pdf:::113256220664810049

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Estradiol.mol:::1132723810234884797

# SDF_File_[Text]:
tbl_chemical:::HMDB00151.sdf:::119283219243652430

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00151.pdb:::119283219627256429

# PDB_ID:
1A27

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Estradiol.gif:::1132732114234415080

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00151_peaks.txt:::1156309578249642177

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Estradiol_C.gif:::1132737700409677294

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00151_peaks.txt:::1156310768068656596

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00151L.png:::117555262310583781; Medium Energy:tbl_ms:::HMDB00151M.png:::117555267630316980; High Energy:tbl_ms:::HMDB00151H.png:::117555271257694314

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane (Predicted from LogP); Cytoplasm; endoplasmic reticulum

# Tissue_Location:
Adipose Tissue; Adrenal Cortex; Adrenal Gland; Brain; Epidermis; Fibroblasts; Gonads; Muscle; Neurons; Placenta; Platelet; Prostate; Spleen; Stratum Corneum; Testes; Testis; Uterus

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Saliva

# Concentration_[Normal]:
Blood	<=0.00018	umol/L	Adult:>18_yrs_old	Male	Normal	Merck Manual
Cerebrospinal_Fluid(CSF)	0.0000011 +/- 0.0000003	uM	Adult:>18_yrs_old	Female	Normal	10585175
Cerebrospinal_Fluid(CSF)	0.0000007 - 0.000011	uM	Adult:>18_yrs_old	Female	Normal	10585175 
Saliva	<1.00	umol/L	Adult:>18_yrs_old	Both	Normal	16155259


# Concentration_[Abnormal]:
Blood	0.00039 (0.000037-0.00073)	umol/L	Adult:>18_yrs_old	Female	Female Follicular phase	Merck Manual
Blood	0.00092 (0.00037-0.0015)	umol/L	Adult:>18_yrs_old	Female	Female Midcycle	Merck Manual
Blood	0.00050 (0.000055-0.00095)	umol/L	Adult:>18_yrs_old	Female	Female Luteal phase	Merck Manual
Blood	<= 0.00018	umol/L	Adult:>18_yrs_old	Female	Postmenopausal	Merck Manual
Cerebrospinal_Fluid(CSF)	0.000006 (0.0000007-0.000011)	N/A	Adult:>18_yrs_old	N/A	Women with benign gynecological diseases	10585175


# Associated_Disorders:
Breast Cancer; Female Follicular phase; Female Luteal phase; Female Midcycle; Osteoporosis; Postmenopausal; Thymoma; Women with benign gynecological diseases

# Pathway_Names:
Pentose and glucuronate interconversions;Androgen and estrogen metabolism;Starch and sucrose metabolism;Porphyrin and chlorophyll metabolism;Fatty acid biosynthesis (path 2);Fatty acid metabolism;Valine, leucine and isoleucine degradation;Lysine degradation;Benzoate degradation via CoA ligation;Butanoate metabolism;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
;;;;;;valine,leucine,and_isoleucine_degradation.jpg;Lysine_degradation.jpg;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00040;map00150;map00500;map00860;map00062;map00071;map00280;map00310;map00632;map00650;map00280;map00280

# Pathway_Graphs:
;;;;;;valine,leucine,and_isoleucine_degradation_Graph.jpg;Lysine_degradation_Graph.jpg;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
;;;;;;valine,leucine,and_isoleucine_degradation.xml;Lysine_degradation.xml;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5731

# Metabolic_Enzyme_1_Name:
UDP-glucuronosyltransferase 2B17 precursor

# Metabolic_Enzyme_1_Synonyms:
UDPGT; C19- steroid-specific UDP-glucuronosyltransferase

# Metabolic_Enzyme_1_Gene_Name:
UGT2B17

# Metabolic_Enzyme_1_Protein_Sequence:
>UDPglucuronosyltransferase 2B17 precursor
MSLKWMSVFLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSA
SILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEY
SDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYT
VEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEV
LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
MSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVA
AHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLFCFRKLAKTGKKKKRD

# Metabolic_Enzyme_1_Number_of_Residues:
530

# Metabolic_Enzyme_1_Molecular_Weight:
61096

# Metabolic_Enzyme_1_Theoretical_pI:
8.73

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3alpha,17beta-diol (3alpha-diol) > testosterone > androsterone (ADT)

# Metabolic_Enzyme_1_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_1_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_1_Signals:
1-23

# Metabolic_Enzyme_1_Transmembrane_Regions:
495-515

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_1_GenBank_ID_Protein:
3287473

# Metabolic_Enzyme_1_SwissProt_ID:
UDB17_HUMAN (O75795)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
UGT2B17

# Metabolic_Enzyme_1_Geneatlas_id:
UGT2B17

# Metabolic_Enzyme_1_hgnc_id:
HGNC:12547

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Microsome

# Metabolic_Enzyme_1_Gene_Sequence:
>1593 bp
ATGTCTCTGAAATGGATGTCAGTCTTTCTGCTGATGCAGCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATACAGCCATTGGATAAATATGAAG
ACAATCCTGGAAGAGCTTGTTCAGAGGGGTCATGAGGTGATTGTGTTGACATCTTCGGCT
TCTATTCTTGTCAATGCCAGTAAATCATCTGCTATTAAATTAGAAGTTTATCCTACATCT
TTAACTAAAAATGATTTGGAAGATTTTTTTATGAAAATGTTCGATAGATGGACATATAGT
ATTTCAAAAAATACATTTTGGTCATATTTTTCACAACTACAAGAATTGTGTTGGGAATAT
TCTGACTATAATATAAAGCTCTGTGAAGATGCAGTTTTGAACAAGAAACTTATGAGAAAA
CTACAAGAGTCAAAATTTGATGTCCTTCTGGCAGATGCCGTTAATCCCTGTGGTGAGCTG
CTGGCTGAACTACTTAACATACCCTTTCTGTACAGTCTCCGCTTCTCTGTTGGCTACACA
GTTGAGAAGAATGGTGGAGGATTTCTGTTCCCTCCTTCCTATGTACCTGTTGTTATGTCA
GAATTAAGTGATCAAATGATTTTCATGGAGAGGATAAAAAATATGATATATATGCTTTAT
TTTGACTTTTGGTTTCAAGCATATGATCTGAAGAAGTGGGACCAGTTTTATAGTGAAGTT
CTAGGAAGACCCACTACATTATTTGAGACAATGGGGAAAGCTGAAATGTGGCTCATTCGA
ACCTATTGGGATTTTGAATTTCCTCGCCCATTCTTACCAAATGTTGATTTTGTTGGAGGA
CTTCACTGTAAACCAGCCAAACCCTTGCCTAAGGAAATGGAAGAGTTTGTGCAGAGCTCT
GGAGAAAATGGTATTGTGGTGTTTTCTCTGGGGTCGATGATCAGTAACATGTCAGAAGAA
AGTGCCAACATGATTGCATCAGCCCTTGCCCAGATCCCACAAAAGGTTCTATGGAGATTT
GATGGCAAGAAGCCAAATACTTTAGGTTCCAATACTCGACTGTATAAGTGGTTACCCCAG
AATGACCTTCTTGGTCATCCCAAAACCAAAGCTTTTATAACTCATGGTGGAACCAATGGC
ATCTATGAGGCGATCTACCATGGGATCCCTATGGTGGGCATTCCCTTGTTTGCGGATCAA
CATGATAACATTGCTCACATGAAAGCCAAGGGAGCAGCCCTCAGTGTGGACATCAGGACC
ATGTCAAGTAGAGATTTGCTCAATGCATTGAAGTCAGTCATTAATGACCCTATCTATAAA
GAGAATATCATGAAATTATCAAGAATTCATCATGATCAACCGGTGAAGCCCCTGGATCGA
GCAGTCTTCTGGATTGAGTTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTCGCA
GCCCACAACCTCACCTGGATCCAGTACCACTCTTTGGATGTGATAGCATTCCTGCTGGCC
TGCGTGGCAACTATGATATTTATGATCACAAAATGTTGCCTGTTTTGTTTCCGAAAGCTT
GCCAAAACAGGAAAGAAGAAGAAAAGGGATTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U59209

# Metabolic_Enzyme_1_Chromosome_Location:
Not Available

# Metabolic_Enzyme_1_Locus:
Not Available

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
8798464; 9364925

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5716

# Metabolic_Enzyme_2_Name:
Peroxisomal multifunctional enzyme type 2

# Metabolic_Enzyme_2_Synonyms:
MFE-2; D-bifunctional protein; DBP; 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-3-hydroxyacyl-CoA dehydratase; 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; 3- hydroxyacyl-CoA dehydrogenase

# Metabolic_Enzyme_2_Gene_Name:
HSD17B4

# Metabolic_Enzyme_2_Protein_Sequence:
>Peroxisomal multifunctional enzyme type 2
MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVE
EIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIH
RVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAI
EGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVG
AGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLS
KIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKD
LKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRA
GKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKV
AVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFS
ARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISN
AYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNI
GAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNI
MLSQKLQMILKDYAKL

# Metabolic_Enzyme_2_Number_of_Residues:
736

# Metabolic_Enzyme_2_Molecular_Weight:
79687

# Metabolic_Enzyme_2_Theoretical_pI:
9.21

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  steroid binding
Function:  sterol carrier activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids

# Metabolic_Enzyme_2_Pathway:
map00062  Fatty acid biosynthesis (path 2);
 map00071  Fatty acid metabolism;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00380  Tryptophan metabolism;
 map00632  Benzoate degradation via CoA ligation;
 map00650  Butanoate metabolism;
 map00930  Caprolactam degradation

# Metabolic_Enzyme_2_Reaction:
(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00106:adh_short;
PF01575:MaoC_dehydratas;
PF02036:SCP2

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 4.2.1.107;EC 1.1.1.35

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1050517

# Metabolic_Enzyme_2_SwissProt_ID:
DHB4_HUMAN (P51659)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
HSD17B4

# Metabolic_Enzyme_2_Geneatlas_id:
HSD17B4

# Metabolic_Enzyme_2_hgnc_id:
HGNC:5213

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_2_Gene_Sequence:
>2211 bp
ATGGGCTCACCGCTGAGGTTCGACGGGCGGGTGGTACTGGTCACCGGCGCGGGGGCAGGA
TTGGGCCGAGCCTATGCCCTGGCTTTTGCAGAAAGAGGAGCGTTAGTTGTTGTGAATGAT
TTGGGAGGGGACTTCAAAGGAGTTGGTAAAGGCTCCTTAGCTGCTGATAAGGTTGTTGAA
GAAATAAGAAGGAGAGGTGGAAAAGCAGTGGCCAACTATGATTCAGTGGAAGAAGGAGAG
AAGGTTGTGAAGACAGCCCTGGATGCTTTTGGAAGAATAGATGTTGTGGTCAACAATGCT
GGAATTCTGAGGGATCGTTCCTTTGCTAGGATAAGTGATGAAGACTGGGATATAATCCAC
AGAGTTCATTTGCGGGGTTCATTCCAAGTGACACGGGCAGCATGGGAACACATGAAGAAA
CAGAAGTATGGAAGGATTATTATGACTTCATCAGCTTCAGGAATATATGGCAACTTTGGC
CAGGCCAATTATAGTGCTGCAAAGTTGGGTCTTCTGGGCCTTGCAAATTCTCTTGCAATT
GAAGGCAGGAAAAGCAACATTCATTGTAACACCATTGCTCCTAATGCGGGATCACGGATG
ACTCAGACAGTTATGCCTGAAGATCTTGTGGAAGCCCTGAAGCCAGAGTATGTGGCACCT
CTTGTCCTTTGGCTTTGTCACGAGAGTTGTGAGGAGAATGGTGGCTTGTTTGAGGTTGGA
GCAGGATGGATTGGAAAATTACGCTGGGAGCGGACTCTTGGAGCTATTGTAAGACAAAAG
AATCACCCAATGACTCCTGAGGCAGTCAAGGCTAACTGGAAGAAGATCTGTGACTTTGAG
AATGCCAGCAAGCCTCAGAGTATCCAAGAATCAACTGGCAGTATAATTGAAGTTCTGAGT
AAAATAGATTCAGAAGGAGGAGTTTCAGCAAATCATACTAGTCGTGCAACGTCTACAGCA
ACATCAGGATTTGCTGGAGCTATTGGCCAGAAACTCCCTCCATTTTCTTATGCTTATACG
GAACTGGAAGCTATTATGTATGCCCTTGGAGTGGGAGCGTCAATCAAGGATCCAAAAGAT
TTGAAATTTATTTATGAAGGAAGTTCTGATTTCTCCTGTTTGCCCACCTTCGGAGTTATC
ATAGGTCAGAAATCTATGATGGGTGGAGGATTAGCAGAAATTCCTGGACTTTCAATCAAC
TTTGCAAAGGTTCTTCATGGAGAGCAGTACTTAGAGTTATATAAACCACTTCCCAGAGCA
GGAAAATTAAAATGTGAAGCAGTTGTTGCTGATGTCCTAGATAAAGGATCCGGTGTAGTG
ATTATTATGGATGTCTATTCTTATTCTGAGAAGGAACTTATATGCCACAATCAGTTCTCT
CTCTTTCTTGTTGGCTCTGGAGGCTTTGGTGGAAAACGGACATCAGACAAAGTCAAGGTA
GCTGTAGCCATACCTAATAGACCTCCTGATGCTGTACTTACAGATACCACCTCTCTTAAT
CAGGCTGCTTTGTACCGCCTCAGTGGAGACTGGAATCCCTTACACATTGATCCTAACTTT
GCTAGTCTAGCAGGTTTTGACAAGCCCATATTACATGGATTATGTACATTTGGATTTTCT
GCCAGGCGTGTGTTACAGCAGTTTGCAGATAATGATGTGTCAAGATTCAAGGCAATTAAG
GCTCGTTTTGCAAAACCAGTATATCCAGGACAAACTCTACAAACTGAGATGTGGAAGGAA
GGAAACAGAATTCATTTTCAAACCAAGGTCCAAGAAACTGGAGACATTGTCATTTCAAAT
GCATATGTGGATCTTGCACCAACATCTGGTACTTCAGCTAAGACACCCTCTGAGGGCGGG
AAGCTTCAGAGTACCTTTGTATTTGAGGAAATAGGACGCCGCCTAAAGGATATTGGGCCT
GAGGTGGTGAAGAAAGTAAATGCTGTATTTGAGTGGCATATAACCAAAGGCGGAAATATT
GGGGCTAAGTGGACTATTGACCTGAAAAGTGGTTCTGGAAAAGTGTACCAAGGCCCTGCA
AAAGGTGCTGCTGATACAACAATCATACTTTCAGATGAAGATTTCATGGAGGTGGTCCTG
GGCAAGCTTGACCCTCAGAAGGCATTCTTTAGTGGCAGGCTGAAGGCCAGAGGGAACATC
ATGCTGAGCCAGAAACTTCAGATGATTCTTAAAGACTACGCCAAGCTCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X87176

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_2_Locus:
5q21

# Metabolic_Enzyme_2_SNPs:
rs25640; rs1143650; rs28943589; rs28943594; rs28943592; rs11539471; rs11205; rs28943591; rs28943590; rs28943588; rs2560722; rs12714; rs28943596; rs28943595; rs35293303; rs34753910; rs34353289; rs34604765; rs35520682; rs35233505; rs34381335; rs32659; rs382719; rs32651; rs2678091; rs26181; rs2451816; rs2678070; rs2459726; rs2636962; rs2546210; rs2636968; rs257970; rs1490756; rs2636961; rs2678074; rs10078097; rs26184; rs32665; rs11241506; rs2636964; rs2945327; rs10036783; rs463513; rs161857; rs422297; rs10064000; rs2259347; rs7714121; rs2287712; rs450118; rs257972; rs457106; rs11241507; rs32662; rs439954; rs7716785; rs2560723; rs455949; rs39970; rs161852; rs11957255; rs7706359; rs3797364; rs2652698; rs257973; rs257976; rs3797360; rs11748530; rs12189265; rs12655113; rs174008; rs32661; rs33950298; rs3756512; rs3850200; rs39971; rs32664; rs11746780; rs28590215; rs11749784; rs11949608; rs460274; rs3797368; rs10478424; rs6895345; rs32666; rs426899; rs17145473; rs2636965; rs3797372; rs257971; rs257969; rs2678077; rs6894991; rs3822527; rs150938; rs3797371; rs10041122; rs257985; rs257978; rs9327101; rs2404780; rs33926345; rs3797367; rs7708761; rs10051019; rs7723390; rs12653056; rs3797363; rs491526; rs9885031; rs2678076; rs17453681; rs6897978; rs11952687; rs2678067; rs12658566; rs17145475; rs17145464; rs10069875; rs17388769; rs2546209; rs28943593; rs11748477; rs442923; rs11744058; rs12653702; rs2257900; rs11949545; rs27938; rs6898518; rs6881294; rs528723; rs35509376; rs10440770; rs3756513; rs3850201; rs34072936; rs1155777; rs11738162; rs2546206; rs2678093; rs257974; rs2257901; rs161856; rs36201182; rs34742029; rs17145476; rs2636966; rs257977; rs10061692; rs2075698; rs10057944; rs13361193; rs381703; rs3756510; rs35201279; rs2678092; rs34843661; rs366568; rs2455463; rs10057263; rs36085051; rs2884597; rs10072256; rs9885037; rs10477586; rs10478426; rs10042168; rs34154113; rs257980; rs3933553; rs10041785; rs34480380; rs2678083; rs34894277; rs2303003; rs34554885; rs10045066; rs2678069; rs17145459; rs10040115; rs32663; rs2678075; rs17145471; rs2459727; rs32650; rs460945; rs13360025; rs2678082; rs34787820; rs36121886; rs17145469; rs35312742; rs11950471; rs34061771; rs3797365; rs2636967; rs34414937; rs32649; rs34019509; rs10062410; rs11742193; rs35442141; rs26183; rs2451814; rs3822525; rs257983; rs10463469; rs3797362; rs35908640; rs10073818; rs10045177; rs161851; rs35164142; rs34769530; rs10064454; rs10059654; rs28943586; rs28943587; rs11739468; rs34915828; rs35929961; rs35255511; rs34277908; rs35695978; rs26180; rs34300615; rs35121430; rs11539469; rs35281104; rs34959311; rs34407657; rs35065909; rs11539472; rs35946650; rs154596; rs35416500; rs2678097; rs35150552; rs28771700; rs35717907; rs34077636; rs10069657; rs28488436; rs9327103; rs35972810; rs11441269; rs35331622; rs35370764; rs35118616; rs11423266; rs35557161; rs7702730; rs34241171; rs35764784; rs34076336; rs161855; rs183761; rs3839244; rs13170615; rs28448457; rs28558429; rs34117860; rs10057643; rs34290512; rs3797369; rs2678073; rs6149207; rs11408993; rs34741016; rs35892291; rs35235684; rs11449982; rs34025534; rs34230952; rs2546202; rs9327102; rs13436061; rs28762138; rs35193622; rs13152959; rs2636972; rs35815725; rs35103609; rs2678096; rs4026601; rs34403323; rs5870858; rs13173615; rs2451815; rs3839245; rs3905777; rs13164650; rs161853; rs35896589; rs34776349; rs2636960; rs2546207; rs4472288; rs34797263; rs28371777; rs13179390; rs12658127; rs35513863; rs32660; rs34379490; rs13436451; rs2678071; rs2884596; rs34840516; rs35002045; rs28863779; rs4895193; rs17453513; rs2678072; rs3044997; rs35932005; rs34387330; rs34583966; rs35182344; rs2678068; rs35548886; rs10066301; rs2546203; rs35441752; rs11429994; rs34254740; rs28792671; rs35783015; rs35423756; rs36201214; rs34680033; rs34085452; rs13172850; rs3912770; rs3902524; rs10524491; rs35988302; rs28673725; rs10478425; rs35917386; rs28504028; rs1298928; rs13436186; rs2636959; rs34853445; rs10053773; rs34532819; rs28588064; rs10601221; rs2560724; rs12518814; rs2678095; rs34752619; rs13165698; rs257984; rs34691264; rs35315796; rs35747045; rs34859617; rs33991989; rs4266437; rs36033978; rs3839246; rs35916235; rs34704044; rs35689326; rs33948978; rs28683657; rs257979; rs11423247; rs28447568; rs36012938; rs10066302; rs34132585; rs2546204; rs13356711; rs10434766; rs11959382; rs3951345; rs11435738; rs3797366; rs35833256; rs2678094; rs11438902; rs35335781; rs2546205; rs34941861; rs11949790; rs4084849; rs3907443; rs28667304; rs35246432; rs161854; rs28501075; rs33962138; rs33937106; rs34359926; rs35819200; rs11308278; rs2546208; rs257975; rs7707838; rs34544399; rs2431545; rs28660051; rs11390174; rs2546211; rs2546212; rs13187421; rs13171550; rs11418368; rs5870857; rs35382678; rs12187149; rs35756585; rs13170866; rs35839873; rs36201183; rs2884522; rs12659452; rs2258658; rs35578461; rs3839243; rs34405263; rs35685451; rs13357948; rs6149208; rs35030315; rs35615592; rs3797361; rs32648; rs34464568; rs17552003; rs34245726; rs34926907; rs34429844; rs34401184; rs34212912; rs34142650; rs35833497; rs35305966; rs34812774; rs35181403; rs35999064; rs34198983; rs10043526; rs11951660; rs11955089; rs11956487; rs11959643; rs11959717; rs13361084; rs1651227; rs1651228; rs17145477; rs2560718; rs2560719; rs2560720; rs2561494; rs2636970; rs32647; rs463098

# Metabolic_Enzyme_2_General_References:
7487879; 9089413; 9880674; 8902629; 11700068

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5741

# Metabolic_Enzyme_3_Name:
UDP-glucuronosyltransferase 1-7 precursor

# Metabolic_Enzyme_3_Synonyms:
UDP- glucuronosyltransferase 1A7; UDPGT; UGT1*7; UGT1-07; UGT1.7; UGT- 1G; UGT1G

# Metabolic_Enzyme_3_Gene_Name:
UGT1A7

# Metabolic_Enzyme_3_Protein_Sequence:
>UDPglucuronosyltransferase 17 precursor
MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLF
FSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEG
AQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_3_Number_of_Residues:
530

# Metabolic_Enzyme_3_Molecular_Weight:
59819

# Metabolic_Enzyme_3_Theoretical_pI:
7.85

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_3_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_3_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_3_Signals:
1-25

# Metabolic_Enzyme_3_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_3_GenBank_ID_Protein:
2039360

# Metabolic_Enzyme_3_SwissProt_ID:
UD17_HUMAN (Q9HAW7)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
UGT1A7

# Metabolic_Enzyme_3_Geneatlas_id:
UGT1A7

# Metabolic_Enzyme_3_hgnc_id:
HGNC:12539

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Microsome

# Metabolic_Enzyme_3_Gene_Sequence:
>1593 bp
ATGGCTCGTGCAGGGTGGACTGGCCTCCTTCCCCTATATGTGTGTCTACTGCTGACCTGT
GGCTTTGCCAAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGCCACTGGTTCACC
ATGCAGTCGGTGGTGGAGAAACTCATCCTCAGGGGGCATGAGGTGGTCGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGGAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCA
TACACTCTGGAGGATCAGGACCGGGAGTTCATGGTTTTTGCCGATGCTCGCTGGACGGCA
CCATTGCGAAGTGCATTTTCTCTATTAACAAGTTCATCCAATGGTATTTTTGACTTATTT
TTTTCAAATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGT
TGTTTTGATGCAGTGTTTCTCGATCCTTTTGATGCCTGTGGCTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCGCCAGGGGAATATTTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGACTTCTCTTAGGGTTCTCAGACGCC
ATGACTTTCAAGGAGAGAGTATGGAACCACATCATGCACTTGGAGGAACATTTATTTTGC
CCCTATTTTTTCAAAAATGTCTTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACTGACTTTGTTTTGGAG
TATCCCAAACCCGTGATGCCCAATATGATCTTCATTGGTGGTATCAACTGTCATCAGGGA
AAGCCAGTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGCTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTTCAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U89507

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_3_Locus:
2q37

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
9271343; 11434514; 11037804

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5727

# Metabolic_Enzyme_4_Name:
UDP-glucuronosyltransferase 1-8 precursor

# Metabolic_Enzyme_4_Synonyms:
UDP- glucuronosyltransferase 1A8; UDPGT; UGT1*8; UGT1-08; UGT1.8; UGT- 1H; UGT1H

# Metabolic_Enzyme_4_Gene_Name:
UGT1A8

# Metabolic_Enzyme_4_Protein_Sequence:
>UDPglucuronosyltransferase 18 precursor
MARTGWTSPIPLCVSLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLGKSLNCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLF
FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDACGLIVAKYFSLPSVVFARGIACHYLEEG
AQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLFCQYFSKNALEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_4_Number_of_Residues:
530

# Metabolic_Enzyme_4_Molecular_Weight:
59742

# Metabolic_Enzyme_4_Theoretical_pI:
7.73

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_4_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_4_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_4_Signals:
1-25

# Metabolic_Enzyme_4_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_4_GenBank_ID_Protein:
2613044

# Metabolic_Enzyme_4_SwissProt_ID:
UD18_HUMAN (Q9HAW9)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
UGT1A8

# Metabolic_Enzyme_4_Geneatlas_id:
UGT1A8

# Metabolic_Enzyme_4_hgnc_id:
HGNC:12540

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Microsome

# Metabolic_Enzyme_4_Gene_Sequence:
>1593 bp
ATGGCTCGCACAGGGTGGACCAGCCCCATTCCCCTATGTGTTTCTCTGCTGCTGACCTGT
GGCTTTGCTGAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGTCACTGGTTCACC
ATGCAGTCGGTGGTGGAGAAACTTATCCTCAGGGGGCATGAGGTGGTTGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGGAAAATCACTGAATTGCACAGTGAAGACTTACTCAACCTCA
TACACTCTGGAGGATCTGGACCGGGAATTCATGGATTTCGCCGATGCTCAATGGAAAGCA
CAAGTACGAAGTTTGTTTTCTCTATTTCTGAGTTCATCCAATGGTTTTTTTAACTTATTT
TTTTCGCATTGCAGGAGTTTGTTTAATGACCGAAGATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCGGTGTTTCTTGATCCTTTTGATGCCTGTGCGTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCGCCAGGGGAATAGGTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGAATTCTCTTAGGGTTCTCAGATGCC
ATGGCTTTCAAGGAGAGAGTACGGAACCACATCTTGCACTTGGAGGAACATTTATTTTGC
CAGTATTTTTCCAAAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACACCTGTCACA
GCATATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACAGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAATATGATCTTCATTGGTGGTATCAACTGCCATCAGGGA
AAGCCATTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF030310

# Metabolic_Enzyme_4_Chromosome_Location:
Not Available

# Metabolic_Enzyme_4_Locus:
Not Available

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
9535849; 11434514; 12042666

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5733

# Metabolic_Enzyme_5_Name:
UDP-glucuronosyltransferase 1-5 precursor

# Metabolic_Enzyme_5_Synonyms:
UDP- glucuronosyltransferase 1A5; UDPGT; UGT1*5; UGT1-05; UGT1.5; UGT- 1E; UGT1E

# Metabolic_Enzyme_5_Gene_Name:
UGT1A5

# Metabolic_Enzyme_5_Protein_Sequence:
>UDPglucuronosyltransferase 15 precursor
MATGLQVPLPQLATGLLLLLSVQPWAESGKVLVVPTDGSHWLSMREALRDLHARGHQVVV
LTLEVNMYIKEENFFTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNM
SLIIHRSCVELLHNEALIRHLHATSFDVVLTDPFHLCAAVLAKYLSIPAVFFLRNIPCDL
DFKGTQCPNPSSYIPRLLTTNSDHMTFLQRVKNMLYPLALSYLCHAVSAPYASLASELFQ
REVSVVDLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_5_Number_of_Residues:
534

# Metabolic_Enzyme_5_Molecular_Weight:
60072

# Metabolic_Enzyme_5_Theoretical_pI:
8.14

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_5_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_5_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_5_Signals:
1-28

# Metabolic_Enzyme_5_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_5_GenBank_ID_Protein:
340139

# Metabolic_Enzyme_5_SwissProt_ID:
UD15_HUMAN (P35504)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
UGT1A5

# Metabolic_Enzyme_5_Geneatlas_id:
UGT1A5

# Metabolic_Enzyme_5_hgnc_id:
HGNC:12537

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Microsome

# Metabolic_Enzyme_5_Gene_Sequence:
>867 bp
ATGGCCACAGGACTCCAGGTTCCCCTGCCGCAGCTGGCCACAGGACTGCTGCTTCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGGAAGGTGCTGGTGGTGCCCACTGATGGCAGCCAC
TGGCTCAGCATGCGGGAGGCCTTGCGGGACCTCCATGCGAGAGGCCACCAGGTGGTGGTC
CTCACCCTGGAGGTGAATATGTACATCAAAGAAGAGAACTTTTTCACCCTGACAACGTAT
GCCATTTCATGGACCCAGGACGAATTTGATCGCCTTTTGCTGGGTCACACTCAATCGTTC
TTTGAAACAGAACATCTTCTGATGAAATTTTCTAGAAGAATGGCAATTATGAACAATATG
TCTTTGATCATACATAGGTCTTGTGTGGAGCTACTGCATAATGAGGCCCTGATCAGGCAC
CTGCATGCTACTTCCTTTGATGTGGTTCTAACAGACCCCTTTCACCTCTGCGCGGCGGTG
CTGGCTAAGTACCTGTCGATTCCTGCTGTGTTTTTCTTGAGGAACATTCCATGTGATTTA
GACTTTAAGGGCACACAGTGTCCAAACCCTTCCTCCTATATTCCTAGATTACTAACGACC
AATTCAGACCACATGACATTCCTGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACCTTTGCCATGCTGTTTCTGCTCCTTATGCAAGCCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATCTTGTCAGCCATGCATCTGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGATTACCCCAGGCCGATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACGGGAAGCCACTATCTCAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M84129

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_5_Locus:
2q37

# Metabolic_Enzyme_5_SNPs:
Not Available

# Metabolic_Enzyme_5_General_References:
1339448; 11434514

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5721

# Metabolic_Enzyme_6_Name:
UDP-glucuronosyltransferase 2B7 precursor

# Metabolic_Enzyme_6_Synonyms:
UDPGT; 3,4- catechol estrogen specific; UDPGTh-2

# Metabolic_Enzyme_6_Gene_Name:
UGT2B7

# Metabolic_Enzyme_6_Protein_Sequence:
>UDPglucuronosyltransferase 2B7 precursor
MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSA
SILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFG
DITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTF
EKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVL
GRPTTLSETMGKADVWLIRNSWNFQFPHPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSG
ENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTM
SSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND

# Metabolic_Enzyme_6_Number_of_Residues:
529

# Metabolic_Enzyme_6_Molecular_Weight:
60695

# Metabolic_Enzyme_6_Theoretical_pI:
8.45

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites

# Metabolic_Enzyme_6_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_6_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_6_Signals:
1-23

# Metabolic_Enzyme_6_Transmembrane_Regions:
493-509

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_6_GenBank_ID_Protein:
340080

# Metabolic_Enzyme_6_SwissProt_ID:
UDB7_HUMAN (P16662)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
UGT2B7

# Metabolic_Enzyme_6_Geneatlas_id:
UGT2B7

# Metabolic_Enzyme_6_hgnc_id:
HGNC:12554

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Microsome

# Metabolic_Enzyme_6_Gene_Sequence:
>1590 bp
ATGTCTGTGAAATGGACTTCAGTAATTTTGCTAATACAACTGAGCTTTTGCTTTAGCTCT
GGGAATTGTGGAAAGGTGCTGGTGTGGGCAGCAGAATACAGCCATTGGATGAATATAAAG
ACAATCCTGGATGAGCTTATTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAACAACTCATCCGCTCTTAAAATTGAAATTTATCCCACATCT
TTAACTAAAACTGAGTTGGAGAATTTCATCATGCAACAGATTAAGAGATGGTCAGACCTT
CCAAAAGATACATTTTGGTTATATTTTTCACAAGTACAGGAAATCATGTCAATATTTGGT
GACATAACTAGAAAGTTCTGTAAAGATGTAGTTTCAAATAAGAAATTTATGAAAAAAGTA
CAAGAGTCAAGATTTGACGTCATTTTTGCAGATGCTATTTTTCCCTGTAGTGAGCTGCTG
GCTGAGCTATTTAACATACCCTTTGTGTACAGTCTCAGCTTCTCTCCTGGCTACACTTTT
GAAAAGCATAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAGAA
TTAACTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTACTTT
GACTTTTGGTTCGAAATATTTGACATGAAGAAGTGGGATCAGTTTTATAGTGAAGTTCTA
GGAAGACCCACTACGTTATCTGAGACAATGGGGAAAGCTGACGTATGGCTTATTCGAAAC
TCCTGGAATTTTCAGTTTCCTCATCCACTCTTACCAAATGTTGATTTTGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTGCCTAAGGAAATGGAAGACTTTGTACAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGG
GCCAACGTAATTGCATCAGCCCTGGCCCAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATACCTTAGGTCTCAATACTCGGCTGTATAAGTGGATACCCCAGAAT
GACCTTCTAGGTCATCCAAAGACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TACGAGGCAATCTACCATGGGATCCCTATGGTGGGGATTCCATTGTTTGCCGATCAACCT
GATAACATTGCTCACATGAAGGCCAGGGGAGCAGCTGTTAGAGTGGACTTCAACACAATG
TCGAGTACAGACTTGCTGAATGCATTGAAGAGAGTAATTAATGATCCTTCATATAAAGAG
AATGTTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCTAAACACCTTCGGGTTGCAGCC
CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGTCTGT
GTGGCAACTGTGATATTTATCGTCACAAAATGTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGCAAAGAAGGGAAAAAATGATTAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
J05428

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_6_Locus:
4q13

# Metabolic_Enzyme_6_SNPs:
rs7439366; rs12233719; rs35590824; rs7438284; rs4348159; rs4292394; rs28365062; rs5013211; rs7686056; rs6600884; rs7441750; rs7439152; rs12513195; rs4293848; rs3924192; rs7442453; rs7698846; rs7678656; rs12506962; rs7441774; rs6600888; rs6858558; rs6600885; rs6600891; rs7375178; rs7435335; rs6600890; rs6600887; rs7438244; rs4521414; rs6600889; rs12647682; rs7434332; rs12508257; rs4694628; rs6600886; rs4314347; rs12647681; rs7439326; rs7698645; rs12512526; rs10028494; rs9995928; rs3924194; rs6600892; rs4364327; rs3924193; rs12642938; rs4337789; rs7679184; rs12648462; rs10050146; rs4257713; rs4588522; rs4356975; rs7693957; rs7658752; rs4314345; rs7438942; rs4351080; rs4541594; rs10006452; rs6851533; rs6600880; rs7438135; rs11940316; rs6600879; rs7668282; rs7668258; rs4538548; rs6600883; rs6600893; rs7662029; rs4455491; rs11940220; rs4554144; rs5859163; rs34620993; rs34851008; rs34308305; rs34661811; rs35327868; rs35893826; rs10022440; rs13136922; rs34407256; rs35452834; rs34095769; rs5859161; rs34241812; rs34302283; rs34386959; rs35475910; rs34561399; rs28675300; rs34556519; rs28673873; rs35185848; rs28539948; rs34571475; rs34318523; rs35402056; rs5859162; rs34182209; rs4694177; rs28375964; rs35605246; rs11302069; rs10008743; rs5859160; rs4356974; rs34630750; rs7437605; rs6819882; rs34590280; rs11249527; rs11249528; rs12506592; rs13118991; rs13135225; rs28365063; rs4274916; rs4358465; rs4434330; rs4535394; rs4694169; rs6422323; rs6422324; rs6600876; rs6843382; rs7437174; rs7657423; rs7676472

# Metabolic_Enzyme_6_General_References:
2159463; 11186130

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5719

# Metabolic_Enzyme_7_Name:
UDP-glucuronosyltransferase 1-4 precursor

# Metabolic_Enzyme_7_Synonyms:
UDP- glucuronosyltransferase 1A4; UDPGT; UGT1*4; UGT1-04; UGT1.4; UGT- 1D; UGT1D; Bilirubin-specific UDPGT isozyme 2; HUG-BR2

# Metabolic_Enzyme_7_Gene_Name:
UGT1A4

# Metabolic_Enzyme_7_Protein_Sequence:
>UDPglucuronosyltransferase 14 precursor
MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVV
LTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNV
SLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDL
DFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQ
REVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_7_Number_of_Residues:
534

# Metabolic_Enzyme_7_Molecular_Weight:
60026

# Metabolic_Enzyme_7_Theoretical_pI:
8.68

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

# Metabolic_Enzyme_7_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_7_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_7_Signals:
1-28

# Metabolic_Enzyme_7_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_7_GenBank_ID_Protein:
340137

# Metabolic_Enzyme_7_SwissProt_ID:
UD14_HUMAN (P22310)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
UGT1A4

# Metabolic_Enzyme_7_Geneatlas_id:
UGT1A4

# Metabolic_Enzyme_7_hgnc_id:
HGNC:12536

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Microsome

# Metabolic_Enzyme_7_Gene_Sequence:
>867 bp
ATGGCCAGAGGACTCCAGGTTCCCCTGCCGCGGCTGGCCACAGGACTGCTGCTCCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCACTGATGGCAGCCCC
TGGCTCAGCATGCGGGAGGCCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCGGTGGTC
CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAAATTTTTCACCCTGACAGCCTAT
GCTGTTCCATGGACCCAGAAGGAATTTGATCGCGTTACGCTGGGCTACACTCAAGGGTTC
TTTGAAACAGAACATCTTCTGAAGAGATATTCTAGAAGTATGGCAATTATGAACAATGTA
TCTTTGGCCCTTCATAGGTGTTGTGTGGAGCTACTGCATAATGAGGCCCTGATCAGGCAC
CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGTGGGGCGGTG
CTGGCTAAGTACCTGTCGATTCCTGCTGTGTTTTTTTGGAGGTACATTCCATGTGACTTA
GACTTTAAGGGCACACAGTGTCCAAATCCTTCCTCCTATATTCCTAAGTTACTAACGACC
AATTCAGACCACATGACATTCCTGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACATTTGCCATACTTTTTCTGCCCCTTATGCAAGTCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATCTTGTCAGCTATGCATCCGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGACTACCCCAGGCCGATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACGGGAAGCCACTATCTCAG

# Metabolic_Enzyme_7_GenBank_ID_Gene:
M84128

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_7_Locus:
2q37

# Metabolic_Enzyme_7_SNPs:
Not Available

# Metabolic_Enzyme_7_General_References:
1898728; 1339448; 11434514; 1634050; 8280139; 8276413

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
6127

# Metabolic_Enzyme_8_Name:
Estradiol 17-beta-dehydrogenase 3

# Metabolic_Enzyme_8_Synonyms:
17-beta-HSD 3; Testicular 17-beta-hydroxysteroid dehydrogenase

# Metabolic_Enzyme_8_Gene_Name:
HSD17B3

# Metabolic_Enzyme_8_Protein_Sequence:
>Estradiol 17betadehydrogenase 3
MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGI
GKAYSFELAK
RGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEK
LAGLEIGILVNNVGMLPNLLP
SHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKG
LILNISSGIALFPWPLYSMYSASKAFVCAFSK
ALQEEYKAKEVIIQVLTPYAVSTAMTK
YLNTNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSL
IPAWAFYSGAFQRLLL
THYVAYLKLNTKVR

# Metabolic_Enzyme_8_Number_of_Residues:
310

# Metabolic_Enzyme_8_Molecular_Weight:
34516

# Metabolic_Enzyme_8_Theoretical_pI:
8.84

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH

# Metabolic_Enzyme_8_Pathway:
map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_8_Reaction:
estradiol-17beta + NAD(P)+ = estrone + NAD(P)H + H+

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_8_Signals:
1-24

# Metabolic_Enzyme_8_Transmembrane_Regions:
178-200; 269-291

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.1.1.62

# Metabolic_Enzyme_8_GenBank_ID_Protein:
531162

# Metabolic_Enzyme_8_SwissProt_ID:
DHB3_HUMAN (P37058)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
HSD17B3

# Metabolic_Enzyme_8_Geneatlas_id:
HSD17B3

# Metabolic_Enzyme_8_hgnc_id:
HGNC:5212

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Membrane

# Metabolic_Enzyme_8_Gene_Sequence:
>933 bp

ATGGGGGACGTCCTGGAACAGTTCTTCATCCTCACAGGGCTGCTGGTGTGCCTGGCCTG
CCTGGCGAAGT
GCGTGAGATTCTCCAGATGTGTTTTACTGAACTACTGGAAAGTTTTGC
CAAAGTCTTTCTTGCGGTCAAT
GGGACAGTGGGCAGTGATCACTGGAGCAGGCGATGGA
ATTGGGAAAGCGTACTCGTTCGAGCTAGCAAAA
CGTGGACTCAATGTTGTCCTTATTAG
CCGGACGCTGGAAAAACTAGAGGCCATTGCCACAGAGATCGAGC
GGACTACAGGGAGGA
GTGTGAAGATTATACAAGCAGATTTTACAAAAGATGACATCTACGAGCATATTAA
AGAA
AAACTTGCAGGCTTAGAAATTGGAATTTTAGTCAACAATGTCGGAATGCTTCCAAACCTT
CTCCCA
AGCCATTTCCTGAACGCACCGGATGAAATCCAGAGCCTCATCCATTGTAACAT
CACCTCCGTAGTCAAGA
TGACACAGCTAATTCTGAAACATATGGAATCAAGGCAGAAAG
GTCTCATCCTGAACATTTCTTCTGGGAT
AGCCCTGTTTCCTTGGCCTCTCTACTCCATG
TACTCAGCTTCCAAGGCGTTTGTGTGCGCATTTTCCAAG
GCCCTGCAAGAGGAATATAA
AGCAAAAGAAGTCATCATCCAGGTGCTGACCCCATATGCTGTCTCGACTG
CAATGACAA
AGTATCTAAATACAAATGTGATAACCAAGACTGCTGATGAGTTTGTCAAAGAGTCATTGA
A
TTATGTCACAATTGGAGGTGAAACCTGTGGCTGCCTTGCCCATGAAATCTTGGCGGGC
TTTCTGAGCCTG
ATCCCGGCCTGGGCCTTCTACAGCGGTGCCTTCCAAAGGCTGCTCCT
GACACACTATGTGGCATACCTGA
AGCTCAACACCAAGGTCAGGTAG

# Metabolic_Enzyme_8_GenBank_ID_Gene:
U05659

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_8_Locus:
9q22

# Metabolic_Enzyme_8_SNPs:
rs2066480; rs2066479; rs2066478; rs8190555; rs35189151; rs2224864; rs2066474; rs2066484; rs2066476; rs35024493; rs2026001; rs371119; rs408876; rs999269; rs912463; rs912464; rs375411; rs2147253; rs7039978; rs8190508; rs2476921; rs2476920; rs729390; rs7022250; rs280654; rs8190531; rs2066475; rs8190566; rs6479179; rs7863067; rs416699; rs2243595; rs1927882; rs370438; rs9299363; rs1119864; rs8190513; rs8190542; rs8190541; rs912461; rs8190554; rs2476923; rs441402; rs867807; rs280658; rs2066473; rs10820247; rs2066485; rs8190522; rs1983828; rs2479825; rs407179; rs8190568; rs10125001; rs7037932; rs8190534; rs7868919; rs913580; rs7029101; rs280663; rs8190529; rs166819; rs2476927; rs8190490; rs2066483; rs4401999; rs10739847; rs8190496; rs379734; rs2479821; rs1886260; rs10820208; rs2256618; rs8190504; rs2066487; rs2066477; rs10990258; rs8190535; rs2257157; rs392312; rs12552648; rs7043341; rs8190483; rs8190569; rs1807197; rs2479828; rs2147252; rs8190512; rs2476922; rs8190523; rs11788083; rs7022826; rs280662; rs2066482; rs1810711; rs8190530; rs1927883; rs8190536; rs8190557; rs7873481; rs8190560; rs8190505; rs2987356; rs394243; rs2066486; rs2253502; rs4551481; rs16910680; rs2479824; rs8190549; rs375944; rs2183009; rs11788785; rs2479822; rs8190540; rs8190498; rs12682944; rs8190515; rs280656; rs8190501; rs35056365; rs8190551; rs8190488; rs2479823; rs2066481; rs10820245; rs1225274; rs10990247; rs8190492; rs7042971; rs8190484; rs10820228; rs11789467; rs7859733; rs8190556; rs35688278; rs7040523; rs11791650; rs8190506; rs8190533; rs8190493; rs8190487; rs11789867; rs8190544; rs280665; rs912462; rs8190537; rs12552750; rs8190559; rs8190561; rs2181820; rs400851; rs10990255; rs35567655; rs8190489; rs12683472; rs10117181; rs10820205; rs12684447; rs35638259; rs8190527; rs8190495; rs8190552; rs16910690; rs2476925; rs10820243; rs8190525; rs8190570; rs280657; rs8190500; rs35537194; rs10820188; rs10990236; rs10990246; rs8190497; rs8190514; rs3925451; rs8190532; rs7043452; rs280655; rs6479186; rs12553488; rs10990251; rs8190550; rs4269659; rs2770143; rs10820220; rs8190485; rs10990202; rs8190562; rs16910694; rs13302476; rs34258388; rs8190518; rs8190539; rs35264203; rs6479221; rs35920604; rs1571399; rs280664; rs11791540; rs12686518; rs10990201; rs12005851; rs10990208; rs35010891; rs2987360; rs9409407; rs10820242; rs8190486; rs2476926; rs10733725; rs10820289; rs2026003; rs4743709; rs7029369; rs7872344; rs7048229; rs8190482; rs8190573; rs8190575; rs8190574; rs8190480; rs8190576; rs1324196; rs8190580; rs7848739; rs8190481; rs28932191; rs35907896; rs4743704; rs8190478; rs8190571; rs7848833; rs8190479; rs7024573; rs28932190; rs8190577; rs8190579; rs34862233; rs12003404; rs34268513; rs10524217; rs34020460; rs7357770; rs35605750; rs1753313; rs5899284; rs28393240; rs12345460; rs8190491; rs34712901; rs34749486; rs12377687; rs34607511; rs34252191; rs10990269; rs11324337; rs10684729; rs35463519; rs34835687; rs10990237; rs435265; rs8190546; rs13286372; rs11410872; rs10119272; rs34768651; rs35760395; rs8190565; rs10990350; rs13284535; rs34919185; rs8190511; rs7042315; rs12345464; rs10990203; rs13292483; rs5899282; rs9409053; rs12337479; rs34328277; rs34696429; rs10990349; rs10639612; rs2296211; rs13297204; rs12345498; rs12345462; rs34057561; rs10615794; rs8190545; rs28401600; rs2296210; rs11301816; rs10990320; rs34430175; rs7357765; rs8190510; rs2985282; rs12347921; rs35605782; rs13301464; rs13289967; rs8190519; rs10990146; rs34410351; rs11789590; rs35645593; rs12349596; rs35806560; rs28623339; rs36102384; rs2987357; rs4495556; rs7038184; rs28565462; rs35918093; rs10990348; rs11453214; rs8190517; rs9657644; rs10120717; rs11496626; rs34442358; rs10680950; rs34372619; rs1571400; rs11789582; rs2985281; rs8190548; rs35522080; rs8190538; rs34131940; rs10990306; rs10559450; rs9777382; rs34981993; rs35343617; rs36069609; rs10639457; rs12335993; rs8190547; rs10624364; rs8190502; rs11496541; rs10990254; rs7045594; rs35535710; rs35600106; rs3831056; rs34042448; rs8190543; rs34058347; rs11335254; rs34430203; rs8190499; rs35816882; rs34162871; rs10990356; rs34441335; rs35307721; rs35659617; rs13284833; rs35962525; rs35214327; rs11281254; rs4743685; rs11417524; rs35427805; rs36117803; rs5899285; rs13284819; rs34800961; rs35280549; rs35941200; rs8190509; rs34358443; rs8190521; rs2183010; rs34280228; rs34975803; rs34156466; rs34593569; rs36018805; rs8190558; rs7037679; rs36086036; rs1125964; rs8190563; rs10545828; rs4266767; rs35309344; rs172169; rs35526475; rs8190507; rs33914106; rs5899283; rs182207; rs12345184; rs12339274; rs28523601; rs7357803; rs1238256; rs8190526; rs8190503; rs7869083; rs35263931; rs7852386; rs8190516; rs12345535; rs8190567; rs10990147; rs8190564; rs11515574; rs34686124; rs8190553; rs10990352; rs8190494; rs34577755; rs34024715; rs35689970; rs12342506; rs28421370; rs34355657; rs34140038; rs10541572; rs12338600; rs34849790; rs34051033; rs34240849; rs7049076; rs34912237; rs8190578; rs35789085; rs35188473; rs7045272; rs34721662; rs34190050; rs1408326; rs11327991; rs34108147; rs11286201; rs11789857; rs28931868; rs11307544; rs35917801; rs34037771; rs10820299; rs10820300; rs10990385; rs11788621; rs12350632; rs12552312; rs12555788; rs1887774; rs1887775; rs1927886; rs2025444; rs2031320; rs2031321; rs2476919; rs2479827; rs280661; rs33951726; rs34491501; rs3949818; rs4742910; rs4743712; rs4743713; rs4743715; rs7026934; rs7037304; rs7045639; rs8190581; rs9299367; rs958829; rs958830; rs958831

# Metabolic_Enzyme_8_General_References:
8075637; 8550739; 9758445; 9709959; 11158067

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5724

# Metabolic_Enzyme_9_Name:
UDP-glucuronosyltransferase 2A1 precursor

# Metabolic_Enzyme_9_Synonyms:
Not Available

# Metabolic_Enzyme_9_Gene_Name:
UGT2A1

# Metabolic_Enzyme_9_Protein_Sequence:
>UDPglucuronosyltransferase 2A1 precursor
MLNNLLLFSLQISLIGTTLGGNVLIWPMEGSHWLNVKIIIDELIKKEHNVTVLVASGALF
ITPTSNPSLTFEIYKVPFGKERIEGVIKDFVSTWLENRPSPSTIWRFYQEMAKVIKDFHM
VSQEICDGVLKNQQLMAKLKKSKFEVLVSDPVFPCGDIVALKLGIPFMYSLRFSPASTVE
KHCGKVPYPPSYVPAVLSELTDQMSFTDRIRNFISYHLQDYMFETLWKSWDSYYSKALGR
PTTLCETMGKAEIWLIRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFIQSSGKN
GVVVFSLGSMVKNLTEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDL
LGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTS
VDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHD
LTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKFGKIGKKKKRE

# Metabolic_Enzyme_9_Number_of_Residues:
527

# Metabolic_Enzyme_9_Molecular_Weight:
59873

# Metabolic_Enzyme_9_Theoretical_pI:
9.29

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform is active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium

# Metabolic_Enzyme_9_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_9_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_9_Signals:
1-20

# Metabolic_Enzyme_9_Transmembrane_Regions:
491-507

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_9_GenBank_ID_Protein:
4753766

# Metabolic_Enzyme_9_SwissProt_ID:
UDA1_HUMAN (Q9Y4X1)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
UGT2A1

# Metabolic_Enzyme_9_Geneatlas_id:
UGT2A1

# Metabolic_Enzyme_9_hgnc_id:
HGNC:12542

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Membrane

# Metabolic_Enzyme_9_Gene_Sequence:
>1584 bp
ATGTTAAACAACCTTCTGCTGTTCTCCCTTCAGATAAGTCTCATAGGAACCACTCTTGGT
GGGAATGTTTTGATTTGGCCAATGGAAGGTAGTCATTGGCTAAATGTTAAGATAATTATA
GATGAGCTCATTAAAAAGGAGCATAATGTGACTGTCCTAGTTGCCTCTGGTGCACTTTTC
ATCACACCAACCTCTAACCCATCTCTGACATTTGAAATATATAAGGTGCCCTTTGGCAAA
GAAAGAATAGAAGGAGTAATTAAGGACTTCGTTTCGACATGGCTGGAAAATAGACCATCT
CCTTCAACCATTTGGAGATTCTATCAGGAGATGGCCAAAGTAATCAAGGACTTCCACATG
GTGTCTCAGGAGATCTGTGATGGCGTTCTTAAAAACCAACAGCTGATGGCAAAGCTAAAG
AAAAGCAAGTTTGAAGTCCTGGTGTCTGATCCAGTATTTCCTTGTGGCGATATAGTAGCT
TTAAAACTTGGAATTCCATTTATGTACTCCTTGAGGTTTTCTCCAGCCTCAACAGTGGAA
AAGCACTGTGGGAAGGTACCATACCCTCCTTCCTATGTTCCTGCTGTTTTATCAGAACTC
ACCGACCAAATGTCTTTCACTGACAGAATAAGAAATTTCATCTCCTACCACCTACAGGAC
TACATGTTTGAAACTCTTTGGAAATCATGGGATTCATACTATAGTAAAGCTTTAGGAAGA
CCCACTACGTTATGTGAGACTATGGGGAAAGCTGAAATTTGGTTAATCCGAACATATTGG
GATTTTGAATTTCCTCGTCCATACTTACCTAATTTTGAGTTTGTTGGAGGATTGCACTGC
AAACCTGCCAAACCTTTACCTAAGGAAATGGAAGAATTTATCCAGAGCTCAGGTAAAAAT
GGTGTTGTGGTGTTTTCTCTGGGATCAATGGTCAAAAACCTTACAGAAGAAAAGGCCAAT
CTTATTGCCTCAGCCCTTGCCCAGATTCCACAGAAGGTTTTATGGAGATACAAAGGAAAG
AAACCAGCCACATTAGGAAACAATACTCAGCTCTTTGATTGGATACCCCAGAATGATCTT
CTTGGACATCCCAAAACCAAAGCTTTTATCACTCATGGTGGAACTAATGGGATCTACGAA
GCTATTTACCACGGAGTCCCTATGGTGGGAGTTCCCATGTTTGCTGATCAGCCTGATAAC
ATTGCTCACATGAAGGCCAAAGGAGCAGCTGTGGAAGTGAACCTAAACACAATGACAAGT
GTGGATTTGCTTAGCGCTTTGAGAACAGTCATTAATGAACCTTCTTATAAAGAGAATGCT
ATGAGGTTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTGGATCGAGCAGTCTTC
TGGATCGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTTCGGGTTGCAGCCCATGAC
CTCACCTGGTTCCAGTACCACTCTTTGGATGTAATTGGGTTCTTGCTGGTCTGTGTGACA
ACGGCTATATTTTTGGTCATACAATGTTGTTTGTTTTCCTGTCAAAAATTTGGTAAGATA
GGAAAGAAGAAAAAAAGAGAATAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AJ006054

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_9_Locus:
4q13

# Metabolic_Enzyme_9_SNPs:
rs4148301; rs4148304; rs2163659; rs7668703; rs1432329; rs1432332; rs7659937; rs7672805; rs979363; rs10000435; rs4148279; rs10028495; rs7656541; rs6835972; rs4148276; rs1432330; rs4148277; rs6600796; rs1821185; rs1432335; rs1432336; rs1319811; rs7671313; rs10903210; rs7689493; rs10013528; rs9992698; rs988671; rs6842466; rs6825253; rs4148291; rs11728546; rs2331685; rs2017370; rs4694225; rs6832424; rs6600793; rs1432324; rs1560605; rs2163658; rs4148308; rs4401516; rs6600794; rs988672; rs3775783; rs1036160; rs7655867; rs6854350; rs1835826; rs4148295; rs2288740; rs2288741; rs1438537; rs1432316; rs6853543; rs11249451; rs1158439; rs4148281; rs10001991; rs11946382; rs10518063; rs2033798; rs6600792; rs4048747; rs1432314; rs10033801; rs7676249; rs10026988; rs10028954; rs7662867; rs1432315; rs11249452; rs1835821; rs10006049; rs4148289; rs10011630; rs7662309; rs4148298; rs10021575; rs17147507; rs9999694; rs6846404; rs4694219; rs17147542; rs7692074; rs10023821; rs11933160; rs7662915; rs1967984; rs6855271; rs4148292; rs11249454; rs10033879; rs1432313; rs7685874; rs17147532; rs7665571; rs11736315; rs4473712; rs10023782; rs4694222; rs7670819; rs7699881; rs6824954; rs11936310; rs11936130; rs6600795; rs1432327; rs10011912; rs3822178; rs1835829; rs9999430; rs6848997; rs1835822; rs11942157; rs4148290; rs17674565; rs17674511; rs10004306; rs6811810; rs4148297; rs17618404; rs1583243; rs6858314; rs10012508; rs6832784; rs2217587; rs3775782; rs12507278; rs6855294; rs17147530; rs11731188; rs10009530; rs6824830; rs13129549; rs6831807; rs11736373; rs10006483; rs17618520; rs17680131; rs7680856; rs4148286; rs11931365; rs10023877; rs17618178; rs11722780; rs10027493; rs6826237; rs17147521; rs11249453; rs7688383; rs4148299; rs4148302; rs9997689; rs6814603; rs7681367; rs17674648; rs9917881; rs4148296; rs11721934; rs4148283; rs6849110; rs12501520; rs4148307; rs11736353; rs13120401; rs4550998; rs4148309; rs6839067; rs6852329; rs7670238; rs7668967; rs11946584; rs10022954; rs6832167; rs2010207; rs12500392; rs7690649; rs17617467; rs10013712; rs9993182; rs6846030; rs4148305; rs17618230; rs10026603; rs4694027; rs4148288; rs6831951; rs11730451; rs10005934; rs1897441; rs4395582; rs11729544; rs4148312; rs4280808; rs10518065; rs11929943; rs11929908; rs10033854; rs17147557; rs1550292; rs13134357; rs11939884; rs1432334; rs1432333; rs17619211; rs17681080; rs10471252; rs1347046; rs41292307; rs4148310; rs41292305; rs35926238; rs4148275; rs7674020; rs35816431; rs34251717; rs11438429; rs4148311; rs4694226; rs1368116; rs35378505; rs34607614; rs4148278; rs10649712; rs10682826; rs188964; rs11732515; rs192970; rs11725441; rs28448316; rs33924396; rs28798793; rs17147492; rs324309; rs28413749; rs17147503; rs17147534; rs28404221; rs6600791; rs28570072; rs33943659; rs34090224; rs35971542; rs11460578; rs33999522; rs11441625; rs11323266; rs35281757; rs7677083; rs28776197; rs28782228; rs35910775; rs10583998; rs12644575; rs1967983; rs34446108; rs34142192; rs28544323; rs4148294; rs35582043; rs189787; rs4148285; rs11931171; rs2033801; rs11319385; rs11279957; rs5859193; rs324313; rs4148282; rs33938194; rs7377236; rs34704021; rs36106673; rs28818211; rs28532778; rs34265777; rs4148303; rs13119853; rs36003863; rs1583242; rs34513233; rs985040; rs7686386; rs10691812; rs34650072; rs13112999; rs11721725; rs28759827; rs28726183; rs34028035; rs324310; rs4409023; rs4148320; rs13131759; rs33953975; rs17147520; rs36051343; rs35795947; rs7672793; rs36163528; rs34021488; rs11733854; rs11721681; rs7669007; rs13149874; rs4148322; rs36083211; rs34789624; rs35333044; rs28560222; rs7693686; rs34698455; rs4148306; rs7657761; rs34909158; rs5859194; rs34670944; rs35243459; rs34139484; rs35400584; rs28689093; rs188966; rs11946796; rs11947056; rs11733907; rs28568390; rs34647023; rs10010846; rs6813494; rs7698372; rs28716091; rs10023818; rs35302832; rs34810925; rs34370025; rs4148313; rs4148287; rs34213902; rs35487350; rs35071017; rs10569499; rs33913173; rs28522985; rs34858243; rs28556671; rs34208726; rs34396917; rs4148284; rs11728785; rs28560191; rs28513556; rs28508252; rs36191379; rs4148316; rs4148280; rs4148293; rs7668214; rs2877457; rs34817437; rs2116564; rs11940905; rs10017134; rs28528833; rs35101874; rs33976214; rs34975164; rs34590689; rs34452487; rs2043241; rs3074345; rs35227598; rs34012364; rs34002846; rs28744454; rs34078716; rs34062331; rs5859195; rs35000204; rs33992705; rs10031145; rs33924614; rs11937993; rs13115454; rs1347047; rs1432317; rs1835830; rs4333255; rs6810459; rs7671030; rs7671041; rs7674562; rs7694939; rs9329029; rs9996459

# Metabolic_Enzyme_9_General_References:
10359671

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5734

# Metabolic_Enzyme_10_Name:
UDP-glucuronosyltransferase 2B11 precursor

# Metabolic_Enzyme_10_Synonyms:
UDPGT

# Metabolic_Enzyme_10_Gene_Name:
UGT2B11

# Metabolic_Enzyme_10_Protein_Sequence:
>UDPglucuronosyltransferase 2B11 precursor
MTLKWTSVLLLIHLSCYFSSGSCGKVLVWAAEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDASTLKFEVYPTSLTKTEFENIIMQQVKRWSDIRKDSFWLYFSQEQEILWELY
DIFRNFCKDVVSNKKVMKKLQESRFDIVFADAVFPCGELLAALLNIRFVYSLRFTPGYTI
ERHSGGLIFPPSYIPIVMSKLSDQMTFMERVKNMIYVLYFDFWFQMSDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNVDFVGGFHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRLDFNTM
SSTDLLNALKTVINDPLYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMPHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLACVATVIFIITKFCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_10_Number_of_Residues:
529

# Metabolic_Enzyme_10_Molecular_Weight:
61039

# Metabolic_Enzyme_10_Theoretical_pI:
9.29

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_10_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_10_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_10_Signals:
1-21

# Metabolic_Enzyme_10_Transmembrane_Regions:
493-513

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_10_GenBank_ID_Protein:
3360273

# Metabolic_Enzyme_10_SwissProt_ID:
UDB11_HUMAN (O75310)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
UGT2B11

# Metabolic_Enzyme_10_Geneatlas_id:
UGT2B11

# Metabolic_Enzyme_10_hgnc_id:
HGNC:12545

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Microsome

# Metabolic_Enzyme_10_Gene_Sequence:
>1590 bp
ATGACTCTGAAATGGACTTCAGTTCTTCTGCTGATACATCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAAGTGCTGGTGTGGGCCGCAGAATACAGCCATTGGATGAATATGAAG
ACAATCCTGAAAGAGCTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAATGATGCATCCACTCTTAAATTTGAAGTTTATCCTACATCT
TTAACTAAAACTGAATTTGAGAATATCATCATGCAACAGGTTAAGAGATGGTCAGACATT
CGAAAAGATAGCTTTTGGTTATATTTTTCACAAGAACAAGAAATCCTGTGGGAATTATAT
GACATATTTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAAGTTATGAAAAAACTA
CAAGAGTCAAGATTTGACATCGTTTTTGCAGATGCTGTTTTTCCCTGTGGTGAGCTGCTG
GCTGCGCTACTTAACATACGGTTTGTGTACAGTCTCCGCTTTACTCCTGGCTACACAATT
GAAAGGCACAGTGGAGGACTGATTTTCCCTCCTTCCTACATACCTATTGTTATGTCAAAA
TTAAGTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTATTTT
GACTTTTGGTTCCAAATGTCTGATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTA
GGAAGACCCACTACCTTATTTGAGACAATGGGAAAAGCTGACATATGGCTTATGCGAAAC
TCCTGGAGTTTTCAATTTCCTCATCCATTCTTACCAAACGTTGATTTTGTTGGAGGATTC
CACTGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAGTTTGTACAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAGTGATAAGTAACATGACAGCAGAAAGG
GCCAATGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAC
GGGAATAAACCAGATGCCTTAGGTCTCAATACTCGGCTGTACAAGTGGATACCCCAGAAT
GACCTTCTAGGTCATCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATGAGGCAATCTACCATGGGATCCCTATGGTGGGCATTCCATTGTTTTTTGATCAACCT
GATAACATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGATTGGACTTCAACACAATG
TCGAGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTTATATAAAGAG
AATATTATGAAATTATCAAGAATTCAACATGATCAACCAGTAAAGCCCCTGGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCCCCACAAAGGAGCCAAACACCTTCGAGTTGCAGCC
CATGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTTCTGCTGGCCTGT
GTGGCAACTGTGATATTTATCATCACAAAGTTTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGGGAAGAAGGGAAAAAGAGATTAG

# Metabolic_Enzyme_10_GenBank_ID_Gene:
AF016492

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_10_Locus:
4q13.2

# Metabolic_Enzyme_10_SNPs:
rs4694697; rs4415023; rs4400059; rs4543201; rs4283741; rs11945946; rs7436729; rs11947293; rs4463131; rs6833028; rs12500268; rs4608875; rs7688262; rs7697037; rs3890590; rs7697482; rs35248576; rs11340393; rs5859168; rs4485863; rs28743034; rs4619960; rs13148581; rs13113479; rs4406085; rs34519957; rs13119196; rs28561592; rs4406086; rs13134572; rs7660257; rs13148525; rs35902951; rs13148376; rs4386666; rs13134364; rs13113695; rs4485864; rs13107183; rs7660248; rs13119170; rs13103028; rs13134363; rs35555504; rs13139597; rs35443238; rs28470680; rs13113271; rs13119197; rs13107219; rs10007587; rs4466107; rs10434518; rs34416320; rs10007579; rs6847476; rs10012181; rs9996390; rs12502502; rs13123057; rs4526045; rs4694199; rs6817250; rs6825376; rs7672567; rs7682460; rs7695331

# Metabolic_Enzyme_10_General_References:
9675083

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5687

# Metabolic_Enzyme_11_Name:
UDP-glucuronosyltransferase 2B28 precursor

# Metabolic_Enzyme_11_Synonyms:
UDPGT

# Metabolic_Enzyme_11_Gene_Name:
UGT2B28

# Metabolic_Enzyme_11_Protein_Sequence:
>UDPglucuronosyltransferase 2B28 precursor
MALKWTSVLLLIHLGCYFSSGSCGKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDIQKDSFWLYFSQEQEILWEFH
DIFRNFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTI
ERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWFQMCDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTM
SSTDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAA
RDLTWFQYHSLDVIGFLLACVATVIFVVTKFCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_11_Number_of_Residues:
529

# Metabolic_Enzyme_11_Molecular_Weight:
60907

# Metabolic_Enzyme_11_Theoretical_pI:
8.80

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta- diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active

# Metabolic_Enzyme_11_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_11_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_11_Signals:
1-24

# Metabolic_Enzyme_11_Transmembrane_Regions:
495-517

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_11_GenBank_ID_Protein:
13603476

# Metabolic_Enzyme_11_SwissProt_ID:
UDB28_HUMAN (Q9BY64)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
UGT2B28

# Metabolic_Enzyme_11_Geneatlas_id:
UGT2B28

# Metabolic_Enzyme_11_hgnc_id:
HGNC:13479

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Microsome

# Metabolic_Enzyme_11_Gene_Sequence:
>1590 bp
ATGGCTCTGAAGTGGACTTCAGTTCTTCTGCTGATACATCTCGGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGACCGGTGAATACAGCCATTGGATGAATATGAAG
ACAATCCTGAAAGAGCTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAATGACGCATTCACTCTTAAACTCGAAGTTTATCCTACATCT
TTAACTAAAACTGAATTTGAGAATATCATCATGCAACAGGTTAAGAGATGGTCAGACATT
CAAAAAGATAGCTTTTGGTTATATTTTTCACAAGAACAAGAAATCCTGTGGGAATTTCAT
GACATATTTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAAGTTATGAAAAAACTA
CAAGAGTCAAGATTTGACATCATTTTTGCAGATGCTTTTTTTCCTTGTGGTGAGCTGCTG
GCTGCGCTACTTAACATACCGTTTGTGTACAGTCTCTGCTTCACTCCTGGCTACACAATT
GAAAGGCACAGTGGAGGACTGATTTTCCCTCCTTCCTACATACCTGTTGTTATGTCAAAA
TTAAGTGATCAAATGACTTTCATGGAGAGGGTAAAAAACATGATCTATGTGCTTTATTTT
GACTTTTGGTTCCAAATGTGTGATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTA
GGAAGACCCACTACCTTATTTGAGACAATGGGGAAAGCTGACATATGGCTTATGCGAAAC
TCCTGGAGTTTTCAATTTCCTCATCCATTCTTACCAAACATTGATTTTGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAATTTGTACAGAGCTCTGGT
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAGTGATAAGTAACATGACAGCAGAAAGG
GCCAACGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATGCCTTAGGTCTCAATACTCGGCTGTATAAGTGGATACCCCAGAAT
GACCTTCTAGGTCTTCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATGAGGCAATCTACCATGGGATCCCTATGGTAGGCATTCCATTGTTTTGGGATCAACCT
GATAACATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGACTGGACTTCCACACAATG
TCGAGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTCATATAAAGAG
AATGTTATGAAATTATCAATAATTCAACATGATCAACCAGTAAAGCCCCTGCATCGAGCA
GTCTTCTGGATTGAATTTGTGATGTGCCACAAAGGAGCCAAACACCTTCGAGTTGCAGCC
CGTGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTTCTGCTGGCCTGT
GTGGCAACTGTGATATTTGTCGTCACAAAGTTTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGGGAAGAAGGGAAAAAGAGATTAG

# Metabolic_Enzyme_11_GenBank_ID_Gene:
AF177272

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_11_Locus:
4q13.2

# Metabolic_Enzyme_11_SNPs:
rs4235127; rs4260604; rs4386668; rs11726210; rs10002503; rs4235126; rs3901337; rs4260603; rs10008843; rs4694712; rs4301173; rs4694711; rs2132039; rs9997242; rs4260602; rs4235125; rs4694713; rs7686786; rs10000077; rs7437560; rs7681187; rs10023367; rs7657406; rs41292949; rs6843900; rs6828191; rs41292951; rs10013145; rs7689398; rs41292341; rs13139691; rs13138824; rs4569811; rs6827801; rs34313836; rs5004177; rs28376412; rs13108235; rs5004180; rs4295327; rs4568294; rs4450998; rs33966513; rs5004176; rs35191928; rs13107778; rs4345242; rs34549399; rs4495113; rs5004183; rs41292945; rs41292947; rs35437714; rs35925451; rs13146763; rs28447469; rs35059283; rs5004182; rs7435249; rs5004175; rs5859170; rs4515230; rs6840320; rs35572829; rs5004178; rs5004179; rs4597901; rs41292339; rs5004181; rs13116501; rs10011666; rs41292343; rs7657045; rs13124875; rs9991645; rs35680160; rs6600920

# Metabolic_Enzyme_11_General_References:
11300766

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5725

# Metabolic_Enzyme_12_Name:
UDP-glucuronosyltransferase 1-1 precursor

# Metabolic_Enzyme_12_Synonyms:
UDP- glucuronosyltransferase 1A1; UDPGT; UGT1*1; UGT1-01; UGT1.1; UGT- 1A; UGT1A; Bilirubin-specific UDPGT isozyme 1; HUG-BR1

# Metabolic_Enzyme_12_Gene_Name:
UGT1A1

# Metabolic_Enzyme_12_Protein_Sequence:
>UDPglucuronosyltransferase 11 precursor
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_12_Number_of_Residues:
533

# Metabolic_Enzyme_12_Molecular_Weight:
59592

# Metabolic_Enzyme_12_Theoretical_pI:
8.09

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_12_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

# Metabolic_Enzyme_12_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_12_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_12_Signals:
1-25

# Metabolic_Enzyme_12_Transmembrane_Regions:
491-507

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_12_GenBank_ID_Protein:
184473

# Metabolic_Enzyme_12_SwissProt_ID:
UD11_HUMAN (P22309)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
UGT1A1

# Metabolic_Enzyme_12_Geneatlas_id:
UGT1A1

# Metabolic_Enzyme_12_hgnc_id:
HGNC:12530

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Microsome

# Metabolic_Enzyme_12_Gene_Sequence:
>1602 bp
ATGGCTGTGGAGTCCCAGGGCGGACGCCCACTTGTCCTGGGCCTGCTGCTGTGTGTGCTG
GGCCCAGTGGTGTCCCATGCTGGGAAGATACTGTTGATCCCAGTGGATGGCAGCCACTGG
CTGAGCATGCTTGGGGCCATCCAGCAGCTGCAGCAGAGGGGACATGAAATAGTTGTCCTA
GCACCTGACGCCTCGTTGTACATCAGAGACGGAGCATTTTACACCTTGAAGACGTACCCT
GTGCCATTCCAAAGGGAGGATGTGAAAGAGTCTTTTGTTAGTCTCGGGCATAATGTTTTT
GAGAATGATTCTTTCCTGCAGCGTGTGATCAAAACATACAAGAAAATAAAAAAGGACTCT
GCTATGCTTTTGTCTGGCTGTTCCCACTTACTGCACAACAAGGAGCTCATGGCCTCCCTG
GCAGAAAGCAGCTTTGATGTCATGCTGACGGACCCTTTCCTTCCTTGCAGCCCCATCGTG
GCCCAGTACCTGTCTCTGCCCACTGTATTCTTCTTGCATGCACTGCCATGCAGCCTGGAA
TTTGAGGCTACCCAGTGCCCCAACCCATTCTCCTACGTGCCCAGGCCTCTCTCCTCTCAT
TCAGATCACATGACCTTCCTGCAGCGGGTGAAGAACATGCTCATTGCCTTTTCACAGAAC
TTTCTGTGCGACGTGGTTTATTCCCCGTATGCAACCCTTGCCTCAGAATTCCTTCAGAGA
GAGGTGACTGTCCAGGACCTATTGAGCTCTGCATCTGTCTGGCTGTTTAGAAGTGACTTT
GTGAAGGATTACCCTAGGCCCATCATGCCCAATATGGTTTTTGTTGGTGGAATCAACTGC
CTTCACCAAAATCCACTATCCCAGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACAT
GGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATG
GCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACC
CGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTG
CTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAA
AGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAAT
GCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCT
GAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATC
ATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTC
TGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGAC
CTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTG
ACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAA
AAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
M57899

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_12_Locus:
2q37

# Metabolic_Enzyme_12_SNPs:
Not Available

# Metabolic_Enzyme_12_General_References:
1898728; 1339448; 11434514; 1634050; 8280139; 8276413; 8226884; 7989045; 7989595; 7715297; 9621515; 9627603

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5696

# Metabolic_Enzyme_13_Name:
UDP-glucuronosyltransferase 2B4 precursor

# Metabolic_Enzyme_13_Synonyms:
UDPGT; Hyodeoxycholic acid; HLUG25; UDPGTh-1

# Metabolic_Enzyme_13_Gene_Name:
UGT2B4

# Metabolic_Enzyme_13_Protein_Sequence:
>UDPglucuronosyltransferase 2B4 precursor
MSMKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLASSA
SISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFN
DILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFGELLAELLKIPFVYSLRFSPGYAI
EKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVL
GRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSMVSNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTM
SSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVTGFLLACVATVIFIITKCLFCVWKFVRTGKKGKRD

# Metabolic_Enzyme_13_Number_of_Residues:
528

# Metabolic_Enzyme_13_Molecular_Weight:
60513

# Metabolic_Enzyme_13_Theoretical_pI:
8.75

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_13_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid

# Metabolic_Enzyme_13_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_13_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_13_Signals:
1-23

# Metabolic_Enzyme_13_Transmembrane_Regions:
493-509

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_13_GenBank_ID_Protein:
37589

# Metabolic_Enzyme_13_SwissProt_ID:
UDB4_HUMAN (P06133)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
UGT2B4

# Metabolic_Enzyme_13_Geneatlas_id:
UGT2B4

# Metabolic_Enzyme_13_hgnc_id:
HGNC:12553

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Microsome

# Metabolic_Enzyme_13_Gene_Sequence:
>1587 bp
ATGTCTATGAAATGGACTTCAGCTCTTCTGCTGATACAGCTGAGCTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATTCAGCCACTGGATGAATATAAAG
ACAATCCTGGATGAACTTGTCCAGAGAGGTCATGAGGTGACTGTATTGGCATCTTCAGCT
TCCATTTCTTTCGATCCCAACAGCCCATCTACTCTTAAATTTGAAGTTTATCCTGTATCT
TTAACTAAAACTGAGTTTGAGGATATTATCAAGCAGCTGGTTAAGAGATGGGCAGAACTT
CCAAAAGACACATTTTGGTCATATTTTTCACAAGTACAAGAAATCATGTGGACATTTAAT
GACATACTTAGAAAGTTCTGTAAGGATATAGTTTCAAATAAGAAACTTATGAAGAAACTA
CAGGAGTCAAGATTTGATGTTGTTCTTGCAGATGCTGTTTTCCCCTTTGGTGAGCTGCTG
GCCGAGTTACTTAAAATACCCTTTGTCTACAGGCCTCGCTTCTCTCCTGGCTACGCAATT
GAAAAGCATAGTGGAGGACTTCTGTTCCCTCCTTCCTATGTGCCTGTTGTTATGTCAGAA
CTAAGTGACCAAATGACTTTCATAGAGAGGGTAAAAAATATGATCTATGTGCTTTATTTT
GAATTTTGGTTCCAAATATTTGACATGAAGAAGTGGGATCAGTTCTACAGTGAAGTTCTA
GGAAGACCCACTACGTTATCTGAGACAATGGCAAAAGCTGACATATGGCTTATTCGAAAC
TACTGGGATTTTCAATTTCCTCACCCACTCTTACCAAATGTTGAGTTCGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTACCGAAGGAAATGGAAGAGTTTGTCCAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCGATGGTCAGTAACACGTCAGAAGAAAGG
GCCAATGTAATTGCATCAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATACTTTAGGACTCAATACTCGGCTGTACAAGTGGATACCCCAGAAT
GATCTTCTTGGTCACCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATAAGGCAATCTCTCCTAGAATCCCTATGGTGGGCGTTCCATTGTTTGCAGATCAACCT
GATAACATTGCACACATGAAGGCCAAGGGAGCAGCTGTTAGTTTGGACTTCCACACAATG
TCGAGTACAGACTTACTCAATGCACTGAAGACAGTAATTAATGATCCTTTATATAAAGAG
AATGCTATGAAATTATCAAGAATTCATCATGATCAACCAGTGAAGCCCCTTGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTTGCAGCC
CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGACTGGGTTCCTGCTGGCCTGT
GTGGCAACTGTGATATTCATCATCACAAAATGTCTGTTTTGTGTCTGGAAGTTTGTTAGA
ACAGGAAAGAAGGGGAAAAGAGATTAA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
Y00317

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_13_Locus:
4q13

# Metabolic_Enzyme_13_SNPs:
rs13119049; rs41297431; rs13142440; rs1131878; rs1966151; rs1051752; rs7662902; rs1389930; rs1826690; rs7441743; rs1039007; rs2220857; rs2013562; rs1845557; rs6833511; rs13116232; rs12645716; rs9997034; rs1994936; rs1039008; rs4554145; rs28542932; rs10030234; rs10518061; rs17614939; rs13104260; rs10010875; rs3822179; rs33914959; rs1845556; rs6848208; rs17671289; rs1977017; rs28361541; rs41297733; rs41297437; rs1997581; rs41297373; rs41299996; rs41297395; rs41297371; rs41300016; rs41297381; rs41297421; rs1908406; rs41297427; rs41297377; rs41297425; rs41297367; rs4557343; rs1845558; rs3075630; rs41297405; rs41297739; rs41297383; rs41297721; rs13151870; rs41297441; rs13145834; rs13104687; rs11249442; rs41297407; rs41297429; rs41297727; rs1121124; rs2013573; rs41299994; rs13139888; rs41297439; rs41297409; rs1494802; rs13111134; rs6600771; rs6820660; rs6821129; rs941389; rs2736446; rs1080755; rs2736442; rs28858389; rs2736441; rs41298271; rs41298263; rs41299972; rs41298261; rs41298251; rs13129471; rs41299970; rs6821910; rs41298253; rs41298259; rs41298265; rs41298245; rs41299978; rs41299976; rs41299974; rs41300004; rs17852375; rs1845555; rs41298247; rs28679647; rs324405; rs41300006; rs36048401; rs1432328; rs41297387; rs41299984; rs41299998; rs41299992; rs41297735; rs41297423; rs35143721; rs1370886; rs41299980; rs41297389; rs41297729; rs7441132; rs41297435; rs34002802; rs41297731; rs41300018; rs35138624; rs41297391; rs41297369; rs41297737; rs41297413; rs13141359; rs41292303; rs41300008; rs2736447; rs41300014; rs41297401; rs34874998; rs1370887; rs41297399; rs41297379; rs172861; rs41297375; rs10613760; rs41297433; rs41297723; rs41297403; rs41297741; rs1821190; rs34030380; rs324406; rs41299986; rs41297393; rs41297385; rs41297419; rs41297365; rs35471760; rs34861432; rs4515233; rs324408; rs41297411; rs2018304; rs41300012; rs13114834; rs41297415; rs28629208; rs41300002; rs41300000; rs41300010; rs41297743; rs41297397; rs41299990; rs28419590; rs983988; rs34164957; rs1370885; rs324407; rs34466016; rs41297725; rs41297417; rs34114694; rs41299988; rs41299982; rs41299966; rs34846583; rs35045255; rs35834953; rs34169605; rs1318156; rs2642856; rs35159034; rs41298257; rs41298249; rs2736445; rs3075626; rs41299968; rs28847667; rs34146174; rs36057237; rs28812576; rs941390; rs41298255; rs28894673; rs41298269; rs1080756; rs41298267; rs10000231; rs10015297; rs11725944; rs11725945; rs13141436; rs13143630; rs1569343; rs1569344; rs1594588; rs1603119; rs1948499; rs2010468; rs2642849; rs2642872; rs2736462; rs2736476; rs2736517; rs2736520; rs35347166; rs4694749; rs7657880; rs903445; rs903446; rs9996511

# Metabolic_Enzyme_13_General_References:
3109396; 8333863; 10376768

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5685

# Metabolic_Enzyme_14_Name:
Estradiol 17-beta-dehydrogenase 2

# Metabolic_Enzyme_14_Synonyms:
17-beta-HSD 2; Microsomal 17-beta-hydroxysteroid dehydrogenase; 20 alpha- hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH

# Metabolic_Enzyme_14_Gene_Name:
HSD17B2

# Metabolic_Enzyme_14_Protein_Sequence:
>Estradiol 17betadehydrogenase 2
MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL
FSVSCFLMYT
YLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGP
GAEELRRTCSPRLSVLQMDIT
KPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGE
LLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKS
KGRLVNVSSMGGGAPMERLASYGSSKA
AVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLE
KDILDHLPAEVQEDYG
QDYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICL
AHYLP
IGIYDYFAKRHFGQDKPMPRALRMPNYKKKAT

# Metabolic_Enzyme_14_Number_of_Residues:
387

# Metabolic_Enzyme_14_Molecular_Weight:
42786

# Metabolic_Enzyme_14_Theoretical_pI:
8.62

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH

# Metabolic_Enzyme_14_Pathway:
map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_14_Reaction:
estradiol-17beta + NAD(P)+ = estrone + NAD(P)H + H+

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_14_Signals:
1-20

# Metabolic_Enzyme_14_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 1.1.1.62

# Metabolic_Enzyme_14_GenBank_ID_Protein:
306462

# Metabolic_Enzyme_14_SwissProt_ID:
DHB2_HUMAN (P37059)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
HSD17B2

# Metabolic_Enzyme_14_Geneatlas_id:
HSD17B2

# Metabolic_Enzyme_14_hgnc_id:
HGNC:5211

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Metabolic_Enzyme_14_Gene_Sequence:
>1164 bp

ATGAGCACTTTCTTCTCGGACACAGCATGGATCTGCCTGGCTGTCCCCACAGTACTATG
TGGGACAGTAT
TTTGCAAATACAAGAAGAGCTCAGGGCAGCTGTGGAGCTGGATGGTCT
GCCTGGCAGGCCTCTGTGCAGT
CTGCCTGCTCATCCTGTCCCCTTTTTGGGGCTTGATC
CTCTTCTCGGTGTCATGCTTCCTCATGTATACT
TACTTATCTGGCCAAGAATTGTTACC
TGTGGATCAGAAGGCAGTCCTGGTGACAGGTGGTGATTGCGGGC
TTGGCCATGCTTTGT
GCAAGTATCTGGATGAGCTGGGCTTCACGGTATTTGCCGGAGTTTTGAATGAAAA
TGGC
CCAGGAGCTGAGGAATTGCGAAGAACCTGCTCTCCGCGCCTCTCGGTGCTCCAAATGGAC
ATCACG
AAGCCAGTGCAGATAAAAGATGCTTACAGCAAGGTTGCAGCAATGCTGCAGGA
CAGAGGACTGTGGGCTG
TGATCAACAATGCTGGGGTGCTTGGCTTTCCAACTGATGGGG
AGCTTCTTCTTATGACTGACTACAAACA
ATGCATGGCCGTGAACTTCTTTGGAACTGTG
GAGGTCACAAAGACGTTTTTGCCTCTTCTTAGAAAATCC
AAAGGGAGGCTGGTGAATGT
CAGCAGCATGGGAGGAGGGGCCCCAATGGAAAGGCTGGCATCTTATGGCT
CATCAAAGG
CGGCTGTGACCATGTTCTCATCAGTTATGAGACTGGAGCTTTCCAAGTGGGGAATTAAAG
T
TGCTTCCATCCAACCTGGAGGCTTCCTAACAAATATCGCAGGCACCAGTGACAAGTGG
GAAAAGCTGGAG
AAGGACATTCTGGACCACCTCCCCGCTGAGGTACAGGAAGACTACGG
CCAGGACTACATCTTAGCACAGC
GGAATTTCCTCCTATTGATCAACTCGTTAGCCAGCA
AGGACTTCTCTCCGGTGCTGCGGGACATCCAGCA
TGCTATCTTGGCGAAGAGCCCTTTT
GCCTATTACACGCCAGGGAAAGGCGCTTACTTGTGGATCTGCCTT
GCTCACTATTTGCC
TATTGGCATATATGATTACTTTGCTAAAAGACATTTTGGCCAAGACAAGCCCATGC
CCA
GAGCTCTAAGAATGCCTAACTACAAGAAAAAGGCCACCTAG

# Metabolic_Enzyme_14_GenBank_ID_Gene:
L11708

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_14_Locus:
16q24.1-q24.2

# Metabolic_Enzyme_14_SNPs:
rs8191136; rs8191246; rs8191135; rs8191244; rs4445895; rs2966250; rs1364285; rs1364286; rs2042429; rs1017242; rs2966245; rs2955152; rs2955163; rs2966249; rs1364287; rs2955162; rs1017243; rs8046533; rs7196807; rs8060685; rs2966246; rs1424151; rs8191080; rs8049510; rs7200711; rs7203384; rs7205968; rs4318193; rs1559428; rs7201637; rs8191068; rs8191077; rs9319572; rs8049006; rs8049423; rs2911422; rs8191112; rs8050327; rs2966244; rs723012; rs4628962; rs4889456; rs8049750; rs8047385; rs7200696; rs2911420; rs7201121; rs2955159; rs8048090; rs4889453; rs8191089; rs9940004; rs8048018; rs7192075; rs11150437; rs8191167; rs11150436; rs8044837; rs8052451; rs7196087; rs8191156; rs3751860; rs7196609; rs6564961; rs8044382; rs8191159; rs11648233; rs11863907; rs8046220; rs8045494; rs2873459; rs2966241; rs16956274; rs7498701; rs723013; rs8191160; rs8056343; rs16956373; rs8191175; rs4888202; rs8191113; rs4889457; rs11150435; rs11642323; rs1559427; rs16956356; rs7184155; rs7184121; rs8191088; rs4398102; rs8191163; rs1816121; rs8191114; rs9929854; rs8191138; rs8191057; rs8059915; rs10514523; rs8191235; rs13339413; rs8191165; rs8191111; rs2966251; rs4480799; rs1559429; rs8191097; rs4497679; rs10514522; rs8191058; rs9788807; rs1981878; rs8191183; rs8191102; rs8191146; rs8191072; rs8061074; rs8191243; rs4468615; rs3111351; rs11865667; rs11865023; rs11150434; rs8191120; rs4243229; rs8191119; rs7186963; rs8191101; rs4453484; rs8054838; rs8191144; rs9889094; rs9939740; rs8191134; rs2955160; rs4589548; rs8191169; rs11860188; rs2966248; rs8191094; rs13337293; rs8191170; rs2317419; rs9934209; rs8191208; rs6564962; rs8191066; rs8191143; rs8191125; rs2955156; rs16956282; rs8191110; rs8191236; rs8191065; rs8191105; rs8191154; rs9934783; rs8191055; rs7203108; rs11867054; rs8191126; rs8191220; rs16956406; rs8191177; rs8191056; rs8191115; rs16956279; rs8191237; rs4889452; rs8191157; rs1981880; rs8191118; rs2955155; rs16956363; rs8191219; rs8191198; rs9925455; rs8191173; rs8191070; rs8191123; rs8191194; rs8191207; rs8191121; rs8191152; rs8191069; rs8191141; rs8191099; rs8191117; rs2955153; rs8191184; rs8191206; rs8191212; rs8191095; rs8191148; rs8191197; rs8191084; rs8191226; rs8062467; rs8191100; rs8191147; rs11645641; rs8191122; rs7499494; rs8191140; rs8191174; rs8191204; rs9931597; rs8191155; rs8191137; rs2911417; rs16956276; rs2911418; rs1981879; rs8191186; rs11647954; rs8191129; rs8191232; rs8191132; rs8191233; rs8191223; rs13331247; rs16956360; rs8191093; rs8191083; rs8191164; rs8191062; rs8191158; rs8191205; rs8191171; rs8191178; rs8191192; rs8191131; rs8191124; rs8191242; rs16956351; rs2955151; rs8191224; rs7205168; rs8191195; rs8191130; rs7203506; rs8182164; rs4258604; rs8191225; rs8191188; rs2873503; rs8191127; rs8191202; rs16956292; rs8191081; rs7189128; rs8191181; rs8191210; rs16956326; rs8191241; rs8191142; rs6564964; rs7206573; rs8191231; rs8191180; rs8191073; rs8191071; rs8191059; rs4587969; rs8191161; rs8191082; rs13337657; rs2955157; rs8191054; rs8191211; rs8061420; rs8191075; rs8055526; rs4889451; rs8061331; rs8054931; rs8191049; rs8191048; rs8191248; rs8191050; rs8045403; rs8191044; rs8191047; rs8191045; rs8191051; rs3841245; rs34731990; rs12926193; rs8191053; rs8191245; rs8191052; rs8191209; rs7195902; rs8191109; rs8047676; rs35542346; rs8191116; rs34663442; rs8191168; rs11316956; rs8191201; rs7185224; rs12935336; rs16956349; rs2911419; rs8191196; rs8191086; rs8191063; rs8191218; rs35477676; rs4595797; rs8191079; rs35929573; rs12934918; rs10714516; rs10609893; rs8191067; rs8191074; rs35094236; rs35553743; rs8191191; rs28415730; rs8191087; rs1559430; rs8191234; rs8191104; rs12921045; rs7359416; rs16956334; rs34787393; rs5818365; rs8191185; rs11336584; rs8060661; rs7201778; rs7200873; rs2042428; rs35106065; rs8191098; rs8191064; rs2966243; rs8191090; rs2955154; rs28720979; rs12930423; rs34014888; rs8191061; rs4602032; rs7359419; rs28458323; rs10655291; rs11447223; rs8191149; rs8191078; rs34076692; rs34972528; rs8191085; rs35003963; rs7359420; rs5818366; rs34304419; rs35200926; rs8191106; rs8191214; rs8191213; rs12934750; rs35421064; rs34511068; rs12933612; rs35272646; rs1034475; rs34184569; rs8191230; rs7185037; rs12149935; rs34364464; rs8051789; rs11354860; rs10565122; rs7195231; rs8191150; rs8191215; rs8044959; rs12930422; rs8191228; rs11865855; rs34353182; rs8191187; rs34165598; rs8191145; rs8191182; rs8191172; rs8191096; rs8191162; rs8191076; rs13330917; rs8191139; rs8191240; rs5818364; rs8191153; rs8191060; rs8191216; rs2113283; rs7189336; rs2955158; rs7359410; rs35072627; rs35417845; rs12103269; rs8191227; rs34860346; rs10565056; rs2911421; rs8191107; rs8057705; rs2966247; rs8191176; rs4447422; rs8191238; rs8059728; rs8191166; rs12918089; rs35162139; rs8191151; rs8191108; rs8191091; rs8191221; rs8191199; rs8191200; rs8191229; rs8191217; rs8191222; rs8191189; rs35078894; rs8191133; rs8191103; rs8191239; rs8191128; rs12600162; rs16956386; rs34530732; rs8063624; rs8191092; rs8191190; rs13330818; rs4293372; rs2955161; rs8191179; rs8191193; rs35439668; rs35457032; rs11428727; rs8191046; rs5818363; rs8191247; rs36081729; rs10595118; rs10514524; rs10514525; rs10514526; rs10514527; rs11150433; rs11150438; rs1119933; rs1157100; rs11643002; rs11649253; rs12919119; rs13333018; rs13333826; rs13380561; rs1364283; rs1364284; rs16956236; rs16956238; rs16956242; rs16956244; rs16956248; rs16956419; rs16956433; rs2317615; rs4262939; rs4274431; rs4291899; rs4378606; rs4635338; rs7188332; rs7190839; rs7198264; rs7202378; rs8044330; rs8046900; rs8055539; rs8060285; rs8060993; rs8063114; rs8064117; rs8191249; rs8191250; rs8191251; rs8191253; rs8191256; rs989018; rs989019; rs989020; rs9923501; rs9926000; rs9926211; rs9940683; rs996751; rs996752

# Metabolic_Enzyme_14_General_References:
8099587; 7546291

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5728

# Metabolic_Enzyme_15_Name:
UDP-glucuronosyltransferase 1-3 precursor

# Metabolic_Enzyme_15_Synonyms:
UDP- glucuronosyltransferase 1A3; UDPGT; UGT1*3; UGT1-03; UGT1.3; UGT- 1C; UGT1C

# Metabolic_Enzyme_15_Gene_Name:
UGT1A3

# Metabolic_Enzyme_15_Protein_Sequence:
>UDPglucuronosyltransferase 13 precursor
MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVV
LTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNM
SLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDL
DFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQ
REVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_15_Number_of_Residues:
534

# Metabolic_Enzyme_15_Molecular_Weight:
60339

# Metabolic_Enzyme_15_Theoretical_pI:
8.28

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_15_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_15_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_15_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_15_Signals:
1-28

# Metabolic_Enzyme_15_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_15_GenBank_ID_Protein:
340135

# Metabolic_Enzyme_15_SwissProt_ID:
UD13_HUMAN (P35503)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
UGT1A3

# Metabolic_Enzyme_15_Geneatlas_id:
UGT1A3

# Metabolic_Enzyme_15_hgnc_id:
HGNC:12535

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Microsome

# Metabolic_Enzyme_15_Gene_Sequence:
>867 bp
ATGGCCACAGGACTCCAGGTTCCCCTGCCGTGGCTGGCCACAGGACTGCTGCTTCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCATTGATGGCAGCCAC
TGGCTCAGCATGCGGGAGGTCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCAGTGGTC
CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAACTTTTTCACCCTGACAACCTAT
GCCATTTCGTGGACCCAGGATGAATTTGATCGCCATGTGCTGGGCCACACTCAACTGTAC
TTTGAAACAGAACATTTTCTGAAGAAATTTTTCAGAAGTATGGCAATGTTGAACAATATG
TCTTTGGTCTATCATAGGTCTTGTGTGGAGCTACTACATAATGAGGCCCTGATCAGGCAC
CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGCGCGGCAGTG
CTGGCTAAGTACCTGTCGATTCCTACTGTGTTTTTTTTGAGGAACATTCCATGTGATTTA
GACTTTAAGGGCACACAGTGTCCAAACCCTTCCTCCTATATTCCTAGATTACTAACAACC
AATTCAGACCACATGACATTCATGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACATTTGCCATGCTTTTTCTGCTCCTTATGCAAGCCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATATTCTCAGTCATGCATCTGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGACTACCCCAGGCCAATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACAGGAAGCCACTATCTCAG

# Metabolic_Enzyme_15_GenBank_ID_Gene:
M84127

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_15_Locus:
2q37

# Metabolic_Enzyme_15_SNPs:
Not Available

# Metabolic_Enzyme_15_General_References:
1339448; 11434514

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5730

# Metabolic_Enzyme_16_Name:
UDP-glucuronosyltransferase 1-10 precursor

# Metabolic_Enzyme_16_Synonyms:
UDPGT; UGT1*10; UGT1-10; UGT1.10; UGT-1J; UGT1J

# Metabolic_Enzyme_16_Gene_Name:
UGT1A10

# Metabolic_Enzyme_16_Protein_Sequence:
>UDPglucuronosyltransferase 110 precursor
MARAGWTSPVPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLF
FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEG
AQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_16_Number_of_Residues:
530

# Metabolic_Enzyme_16_Molecular_Weight:
59810

# Metabolic_Enzyme_16_Theoretical_pI:
7.31

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_16_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_16_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_16_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_16_Signals:
1-25

# Metabolic_Enzyme_16_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_16_GenBank_ID_Protein:
2039362

# Metabolic_Enzyme_16_SwissProt_ID:
UD110_HUMAN (Q9HAW8)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
UGT1A10

# Metabolic_Enzyme_16_Geneatlas_id:
UGT1A10

# Metabolic_Enzyme_16_hgnc_id:
HGNC:12531

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Microsome

# Metabolic_Enzyme_16_Gene_Sequence:
>1593 bp
ATGGCTCCGCGCAGGGTGGACCAGCCCCGTTCCTTTATGTGTGTGTCTACTGCTGACCTG
TGGCTTTGCGAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGTCACTGGTTCGCC
ATGCAGTCGGTGGTGGAGAAACTTATCCTCAGGGGGCATGAGGTGGTTGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGAAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCG
TACACTCTGGAAGATCAGAACCGGGAATTCATGGTTTTCGCCCATGCTCAATGGAAAGCA
CAGGCACAAAGTATATTTTCTCTATTAATGAGTTCATCCAGTGGTTTTCTTGACTTATTT
TTTTCGCATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCAGTGTTTCTGGATCCTTTTGATACCTGTGGCTTAATTGTTGCTAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCACCAGGGGAATATTTTGCCGCCATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAATGATCTCTTAGGGTTCTCAGATGCC
ATGACTTTCAAGGAGAGAGTATGGAACCACATCGTGCACTTGGAGGACCATTTATTTTGC
CAGTATCTTTTAAGAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGTCACACATCAATTTGGTTGTTGCGAACGGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAACATGATCTTCATTGGTGGTATCAACTGTCATCAGGGA
AAGCCATTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
U89508

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_16_Locus:
2q37

# Metabolic_Enzyme_16_SNPs:
Not Available

# Metabolic_Enzyme_16_General_References:
9271343; 11434514

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5720

# Metabolic_Enzyme_17_Name:
UDP-glucuronosyltransferase 2B10 precursor

# Metabolic_Enzyme_17_Synonyms:
UDPGT

# Metabolic_Enzyme_17_Gene_Name:
UGT2B10

# Metabolic_Enzyme_17_Protein_Sequence:
>UDPglucuronosyltransferase 2B10 precursor
MALKWTTVLLIQLSFYFSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSAS
ILFDPNDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEILWAIND
IIRNFCKDVVSNKKLMKKLQESRFDIVFADAYLPCGELLAELFNIPFVYSHSFSPGYSFE
RHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWFQIFNMKKWDQFYSEVLG
RPTTLSETMRKADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGE
NGVVVFSLGSMVSNMTEERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQND
LLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMS
STDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAH
NLTWFQYHSLDVIGFLLACVATVLFIITKCCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_17_Number_of_Residues:
528

# Metabolic_Enzyme_17_Molecular_Weight:
60775

# Metabolic_Enzyme_17_Theoretical_pI:
9.40

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_17_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_17_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_17_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_17_Signals:
1-23

# Metabolic_Enzyme_17_Transmembrane_Regions:
492-512

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_17_GenBank_ID_Protein:
516150

# Metabolic_Enzyme_17_SwissProt_ID:
UDB10_HUMAN (P36537)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
UGT2B10

# Metabolic_Enzyme_17_Geneatlas_id:
UGT2B10

# Metabolic_Enzyme_17_hgnc_id:
HGNC:12544

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Microsome

# Metabolic_Enzyme_17_Gene_Sequence:
>1587 bp
ATGGCTCTGAAATGGACTACAGTTCTGCTGATACAACTCAGTTTTTACTTTAGCTCTGGG
AGTTGTGGAAAGGTGCTGGTATGGGCCGCAGAATACAGCCTTTGGATGAATATGAAGACA
ATCCTGAAAGAACTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCTTCC
ATTCTTTTTGATCCCAACGACTCATCCACTCTTAAACTTGAAGTTTATCCTACATCTTTA
ACTAAAACTGAATTTGAGAATATCATCATGCAATTGGTTAAGAGATTGTCAGAAATTCAA
AAAGATACATTTTGGTTACCTTTTTCACAAGAACAAGAAATCCTGTGGGCAATTAATGAC
ATAATTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAACTTATGAAAAAACTACAA
GAGTCAAGATTTGACATCGTTTTTGCAGATGCTTATTTACCCTGTGGTGAGCTGCTGGCT
GAGCTATTTAACATACCCTTTGTGTACAGTCACAGCTTCAGTCCTGGCTACTCATTTGAA
AGGCACAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAAAATTA
AGTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGCTCTATGTGCTTTATTTTGAC
TTTTGGTTCCAAATATTTAATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTAGGA
AGACCCACTACATTATCTGAGACAATGAGGAAAGCTGACATATGGCTTATGCGAAACTCC
TGGAATTTTAAATTTCCTCATCCATTCTTACCAAATGTTGATTTTGTTGGAGGACTCCAC
TGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAGTTTGTACAGAGCTCTGGAGAA
AATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGGGCC
AACGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTTTGGAGATTTGATGGG
AATAAACCAGATGCCTTAGGTCTCAATACTCGACTGTACAAGTGGATACCCCAGAATGAC
CTTCTAGGTCATCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATCTAT
GAGGCAATCTACCATGGGATCCCTATGGTGGGCATTCCATTGTTTTTTGATCAACCTGAT
AATATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGAGTGGACTTCAACACAATGTCG
AGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTCATATAAAGAGAAT
ATTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCAGTC
TTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCCAAACATCTTCGAGTTGCAGCCCAC
AACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGCTTGTGTG
GCAACCGTGCTATTTATCATCACAAAGTGTTGTCTGTTTTGTTTCTGGAAGTTTGCTAGA
AAAGGAAAGAAGGGAAAAAGGGATTAG

# Metabolic_Enzyme_17_GenBank_ID_Gene:
X63359

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_17_Locus:
4q13.2

# Metabolic_Enzyme_17_SNPs:
rs3208727; rs17146903; rs17146904; rs835313; rs835316; rs835309; rs861340; rs844342; rs1841042; rs294778; rs835311; rs2670431; rs294777; rs835317; rs7676529; rs835310; rs11726322; rs11249509; rs1968764; rs7676146; rs1849533; rs17146894; rs835314; rs294772; rs9917967; rs2054221; rs3792628; rs1849534; rs1913316; rs7657958; rs1913315; rs2926036; rs835312; rs1913317; rs4694343; rs835319; rs7673996; rs2670430; rs835315; rs4694344; rs1913318; rs7670334; rs1913320; rs11940320; rs294776; rs4694358; rs294775; rs1976666; rs4095564; rs9917968; rs2942857; rs4116824; rs3215212; rs28563143; rs1902931; rs13111730; rs12506094; rs1979281; rs11347207; rs34334121; rs12511664; rs5859144; rs5859145; rs13141448; rs4116823; rs28377589; rs35887929; rs36003814; rs34999460; rs7678703; rs9917930; rs35390620; rs1902932; rs7674011; rs6839369; rs10007687; rs4095563; rs5859146; rs1902930; rs13148664; rs33938096; rs13110924; rs5859147; rs7685333; rs28586884; rs10428371; rs294771; rs13132114; rs6839806; rs34291505; rs13131461; rs13132118; rs13114078; rs4116825; rs13111722; rs835318; rs17146905; rs34183546; rs35690388; rs11725502; rs35525464; rs11729424; rs11737566; rs11737644; rs1379809; rs1458232; rs1458233; rs294765; rs294770; rs4450999; rs4694340; rs6816491; rs6836993; rs6843220

# Metabolic_Enzyme_17_General_References:
8333863

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
6128

# Metabolic_Enzyme_18_Name:
Estradiol 17-beta-dehydrogenase 1

# Metabolic_Enzyme_18_Synonyms:
17-beta- hydroxysteroid dehydrogenase type 1; 17-beta-HSD 1; Placental 17- beta-hydroxysteroid dehydrogenase; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH

# Metabolic_Enzyme_18_Gene_Name:
HSD17B1

# Metabolic_Enzyme_18_Protein_Sequence:
>Estradiol 17betadehydrogenase 1
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL
ETLQLDVRDS
KSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGT
VRMLQAFLPDMKRRGSGRVLV
TGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG
VHLSLIECGPVHTAFMEKVLGSPEEVLDRTDI
HTFHRFYQYLAHSKQVFREAAQNPEEV
AEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAM
HREVFGDVPAKAEAGA
EAGGGAGPGAEDEAGRSAVGDPELGDPPAAPQ

# Metabolic_Enzyme_18_Number_of_Residues:
328

# Metabolic_Enzyme_18_Molecular_Weight:
34980

# Metabolic_Enzyme_18_Theoretical_pI:
5.42

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  estradiol 17-beta-dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
Process:  estrogen biosynthesis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_18_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_18_Specific_Function:
Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH

# Metabolic_Enzyme_18_Pathway:
map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_18_Reaction:
estradiol-17beta + NAD(P)+ = estrone + NAD(P)H + H+

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_18_Signals:
1-30

# Metabolic_Enzyme_18_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 1.1.1.62

# Metabolic_Enzyme_18_GenBank_ID_Protein:
23365

# Metabolic_Enzyme_18_SwissProt_ID:
DHB1_HUMAN (P14061)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
HSD17B1

# Metabolic_Enzyme_18_Geneatlas_id:
HSD17B1

# Metabolic_Enzyme_18_hgnc_id:
HGNC:5210

# Metabolic_Enzyme_18_PDB_ID:
1QYX

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_18_Gene_Sequence:
>987 bp

ATGGCCCGCACCGTGGTGCTCATCACCGGCTGTTCCTCGGGCATCGGCCTGCACTTGGC
CGTACGTCTGG
CTTCAGATCCATCCCAGAGCTTCAAAGTGTATGCCACGTTGAGGGACC
TGAAAACACAGGGCCGGCTGTG
GGAGGCGGCCCGGGCCCTGGCATGCCCTCCGGGATCC
CTGGAGACGTTGCAGCTGGACGTAAGGGACTCA
AAATCCGTGGCCGCTGCCCGGGAACG
CGTGACTGAGGGCCGCGTGGACGTGCTGGTGTGTAACGCAGGCC
TGGGCCTGCTGGGGC
CGCTGGAGGCGCTGGGGGAGGACGCCGTGGCCTCTGTGCTGGACGTGAATGTAGT
AGGG
ACTGTGCGGATGCTGCAGGCCTTCCTGCCAGACATGAAGAGGCGCGGTTCGGGACGCGTG
TTGGTG
ACCGGGAGCGTGGGAGGATTGATGGGGCTGCCTTTCAATGACGTTTATTGCGC
CAGCAAGTTCGCGCTCG
AAGGCTTATGCGAGAGTCTGGCGGTTCTGCTGCTGCCCTTTG
GGGTCCACTTGAGCCTGATCGAGTGCGG
CCCAGTGCACACCGCCTTCATGGAGAAGGTG
TTGGGCAGCCCAGAGGAGGTGCTGGACCGCACGGACATC
CACACCTTCCACCGCTTCTA
CCAATACCTCGCCCACAGCAAGCAAGTCTTTCGCGAGGCGGCGCAGAACC
CTGAGGAGG
TGGCGGAGGTCTTCCTCACCGCTTTGCGCGCCCCGAAGCCGACCCTGCGCTACTTCACCA
C
CGAGCGCTTCCTGCCCCTGCTGCGGATGCGCCTGGACGACCCCAGCGGCTCCAACTAC
GTCACCGCCATG
CACCGGGAAGTGTTCGGCGACGTTCCGGCAAAGGCCGAGGCTGGGGC
CGAGGCTGGGGGCGGGGCCGGGC
CTGGGGCAGAGGACGAGGCCGGGCGCAGTGCGGTGG
GGGACCCTGAGCTCGGCGATCCTCCGGCCGCCCC
GCAGTAA

# Metabolic_Enzyme_18_GenBank_ID_Gene:
X13440

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_18_Locus:
17q11-q21

# Metabolic_Enzyme_18_SNPs:
rs605059; rs12945667; rs2830; rs2229233; rs2676531; rs597255; rs610166; rs2676530; rs610177; rs676387; rs592389; rs670452; rs470842; rs9915824; rs470885; rs28490403; rs1051381; rs28722471; rs2676532; rs6413434; rs35099842; rs10153; rs675733; rs2854974; rs470904; rs2855481; rs2855482; rs35545131; rs1048170; rs1048178; rs12602084; rs16967862; rs2301132; rs2854977; rs2854978; rs2855484; rs3177667; rs3752386; rs598126; rs607740; rs607795; rs615942; rs621141; rs629861; rs666039; rs668799; rs7219522

# Metabolic_Enzyme_18_General_References:
2846351; 2779584; 2330005; 2197970; 1327779; 5045524; 4719204; 3955020; 6578212; 2547159; 7663947; 8805577; 9525918; 10625652; 8389226

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5726

# Metabolic_Enzyme_19_Name:
UDP-glucuronosyltransferase 1-9 precursor

# Metabolic_Enzyme_19_Synonyms:
UDP- glucuronosyltransferase 1A9; UDPGT; UGT1*9; UGT1-9; UGT1.9; UGT- 1I; UGT1I; lugP4

# Metabolic_Enzyme_19_Gene_Name:
UGT1A9

# Metabolic_Enzyme_19_Protein_Sequence:
>UDPglucuronosyltransferase 19 precursor
MACTGWTSPLPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMRSVVEKLILRGHEVVVVMP
EVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLF
FSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNCGLIVAKYFSLPSVVFARGILCHYLEEG
AQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLLCHRFFKNALEIASEILQTPVT
EYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_19_Number_of_Residues:
530

# Metabolic_Enzyme_19_Molecular_Weight:
59942

# Metabolic_Enzyme_19_Theoretical_pI:
7.96

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_19_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols

# Metabolic_Enzyme_19_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_19_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_19_Signals:
1-25

# Metabolic_Enzyme_19_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_19_GenBank_ID_Protein:
7690346

# Metabolic_Enzyme_19_SwissProt_ID:
UD19_HUMAN (O60656)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
UGT1A9

# Metabolic_Enzyme_19_Geneatlas_id:
UGT1A9

# Metabolic_Enzyme_19_hgnc_id:
HGNC:12541

# Metabolic_Enzyme_19_PDB_ID:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Microsome

# Metabolic_Enzyme_19_Gene_Sequence:
>1593 bp
ATGGCTTGCACAGGGTGGACCAGCCCCCTTCCTCTATGTGTGTGTCTGCTGCTGACCTGT
GGCTTTGCCGAGGCAGGGAAGCTAGTGGTAGTGCCCATGGATGGGAGCCACTGGTTCACC
ATGAGGTCGGTGGTGGAGAAACTCATTCTCAGGGGGCATGAGGTGGTTGTAGTCAGTGCC
AGAGGTGAGTTGGCAACTGGGAAGATCAATGAATTGCACAGTGAAGACTTATTCAACTTC
ATATACCTGGAGGATCTGGACCGGGAGTTCAAGGCTTTTGCCCATGCTCAATGGAAAGCA
CAAGTACGAAGTATATATTCTCTATTAATGGGTTCATACAATGACATTTTTGACTTATTT
TTTTCAAATTGCAGGAGTTTGTTTAAAGACAAAAAATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCAGTGTTTCTCGATCCTTTTGATAACTGTGGCTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCCGTGGTCTTCGCCAGGGGAATACTTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGAATTCTCTTAGGGTTCTCAGATGAC
ATGACTTTCAAGGAGAGAGTACGGAACCACATCATGCACTTGGAGGAACATTTATTATGC
CACCGTTTTTTCAAAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACACCTGTTACG
GAGTATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACGGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAACATGATCTTCATTGGTGGTATCAACTGCCATGAGAGG
AAAGCGTTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GGTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATGC
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCAGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCATGAATGTTCTGGAAATGACTTCTGAAGAATTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTTATGAGGCACAAGGGCGCGACACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGCCGTGCTGACAGTGGCC
TTCATCACCTGTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
S55985

# Metabolic_Enzyme_19_Chromosome_Location:
Not Available

# Metabolic_Enzyme_19_Locus:
Not Available

# Metabolic_Enzyme_19_SNPs:
Not Available

# Metabolic_Enzyme_19_General_References:
1910331; 11434514

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
5691

# Metabolic_Enzyme_20_Name:
Estradiol 17-beta-dehydrogenase 8

# Metabolic_Enzyme_20_Synonyms:
17-beta-HSD 8; 17- beta-hydroxysteroid dehydrogenase 8; Protein Ke6; Ke-6

# Metabolic_Enzyme_20_Gene_Name:
HSD17B8

# Metabolic_Enzyme_20_Protein_Sequence:
>Estradiol 17betadehydrogenase 8
MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGS
KEGPPRGNHA
AFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDD
WDKVIAVNLKGTFLVTQAAAQ
ALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIG
LTQTAARELGRHGIRCNSVLPGFIATPMTQKV
PQKVVDKITEMIPMGHLGDPEDVADVV
AFLASEDSGYITGTSVEVTGGLFM

# Metabolic_Enzyme_20_Number_of_Residues:
261

# Metabolic_Enzyme_20_Molecular_Weight:
26974

# Metabolic_Enzyme_20_Theoretical_pI:
6.50

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_20_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_20_Specific_Function:
Uses estradiol as its preferred substrate

# Metabolic_Enzyme_20_Pathway:
map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_20_Reaction:
estradiol-17beta + NAD(P)+ = estrone + NAD(P)H + H+

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_20_Signals:
None

# Metabolic_Enzyme_20_Transmembrane_Regions:
None

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 1.1.1.62

# Metabolic_Enzyme_20_GenBank_ID_Protein:
30583317

# Metabolic_Enzyme_20_SwissProt_ID:
DHB8_HUMAN (Q92506)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
HSD17B8

# Metabolic_Enzyme_20_Geneatlas_id:
HSD17B8

# Metabolic_Enzyme_20_hgnc_id:
HGNC:3554

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Not Available

# Metabolic_Enzyme_20_Gene_Sequence:
>786 bp

ATGGCGTCTCAGCTCCAGAACCGACTCCGCTCCGCACTGGCCTTGGTCACAGGTGCGGG
GAGCGGCATCG
GCCGAGCGGTCAGTGTACGCCTGGCCGGAGAGGGGGCCACCGTAGCTG
CCTGCGACCTGGACCGGGCAGC
GGCACAGGAGACGGTGCGGCTGCTGGGCGGGCCAGGG
AGCAAGGAGGGGCCGCCCCGAGGGAACCATGCT
GCCTTCCAGGCTGACGTGTCTGAGGC
CAGGGCCGCCAGGTGCCTGCTGGAACAAGTGCAGGCCTGCTTTT
CTCGCCCACCATCTG
TCGTTGTGTCCTGTGCGGGCATCACCCAGGATGAGTTTCTGCTGCACATGTCTGA
GGAT
GACTGGGACAAAGTCATAGCTGTCAACCTCAAGGGCACCTTCCTAGTCACTCAGGCTGCA
GCACAA
GCCCTGGTGTCCAATGGTTGTCGTGGTTCCATCATCAACATCAGTAGCATCGT
AGGAAAGGTGGGGAACG
TGGGGCAGACAAACTATGCAGCATCCAAGGCTGGAGTGATTG
GGCTGACCCAGACCGCAGCCCGGGAGCT
TGGACGACATGGGATCCGCTGTAACTCTGTC
CTCCCAGGGTTCATTGCAACACCCATGACACAGAAAGTG
CCACAGAAAGTGGTGGACAA
GATTACTGAAATGATCCCGATGGGACACTTGGGGGACCCTGAGGATGTGG
CAGATGTGG
TCGCATTCTTGGCATCTGAAGATAGTGGATACATCACAGGGACCTCAGTGGAAGTCACTG
G
AGGTCTTTTCATGTAG

# Metabolic_Enzyme_20_GenBank_ID_Gene:
BT007239

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_20_Locus:
6p21.3

# Metabolic_Enzyme_20_SNPs:
Not Available

# Metabolic_Enzyme_20_General_References:
14574404; 8812499

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
6129

# Metabolic_Enzyme_21_Name:
3-keto-steroid reductase

# Metabolic_Enzyme_21_Synonyms:
Estradiol 17-beta- dehydrogenase 7; 17-beta-HSD 7; 17-beta-hydroxysteroid dehydrogenase 7

# Metabolic_Enzyme_21_Gene_Name:
HSD17B7

# Metabolic_Enzyme_21_Protein_Sequence:
>3ketosteroid reductase
MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIV
QVDVSNLQSV
FRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFST
AEGLLTQGDKITADGLQEVFE
TNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSN
FSLEDFQHSKGKEPYSSSKYATDLLSVALNRN
FNQQGLYSNVACPGTALTNLTYGILPP
FIWTLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLN
PLIKYLSATTGFGRNY
IMTQKMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL

# Metabolic_Enzyme_21_Number_of_Residues:
341

# Metabolic_Enzyme_21_Molecular_Weight:
38207

# Metabolic_Enzyme_21_Theoretical_pI:
8.21

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_21_Specific_Function:
Responsible for the reduction of the keto group on the C-3 of sterols

# Metabolic_Enzyme_21_Pathway:
map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_21_Reaction:
4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP+ = 4alpha-methyl-5alpha-cholest-7-en-3-one + NADPH + H+

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_21_Signals:
1-19

# Metabolic_Enzyme_21_Transmembrane_Regions:
230-250

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 1.1.1.270;EC 1.1.1.62

# Metabolic_Enzyme_21_GenBank_ID_Protein:
6721095

# Metabolic_Enzyme_21_SwissProt_ID:
DHB7_HUMAN (P56937)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
HSD17B7

# Metabolic_Enzyme_21_Geneatlas_id:
HSD17B7

# Metabolic_Enzyme_21_hgnc_id:
HGNC:5215

# Metabolic_Enzyme_21_PDB_ID:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Membrane; single-pass membrane protein

# Metabolic_Enzyme_21_Gene_Sequence:
>1026 bp

ATGCGAAAGGTGGTTTTGATCACCGGGGCTAGCAGTGGCATTGGCCTGGCCCTCTGCAA
GCGGCTGCTGG
CGGAAGATGATGAGCTTCATCTGTGTTTGGCGTGCAGGAACATGAGCA
AGGCAGAAGCTGTCTGTGCTGC
TCTGCTGGCCTCTCACCCCACTGCTGAGGTCACCATT
GTCCAGGTGGATGTCAGCAACCTGCAGTCGGTC
TTCCGGGCCTCCAAGGAACTTAAGCA
AAGGTTTCAGAGATTAGACTGTATATATCTAAATGCTGGGATCA
TGCCTAATCCACAAC
TAAATATCAAAGCACTTTTCTTTGGCCTCTTTTCAAGAAAAGTGATTCATATGTT
CTCC
ACAGCTGAAGGCCTGCTGACCCAGGGTGATAAGATCACTGCTGATGGACTTCAGGAGGTG
TTTGAG
ACCAATGTCTTTGGCCATTTTATCCTGATTCGGGAACTGGAGCCTCTCCTCTG
TCACAGTGACAATCCAT
CTCAGCTCATCTGGACATCATCTCGCAGTGCAAGGAAATCTA
ATTTCAGCCTCGAGGACTTCCAGCACAG
CAAAGGCAAGGAACCCTACAGCTCTTCCAAA
TATGCCACTGACCTTTTGAGTGTGGCTTTGAACAGGAAC
TTCAACCAGCAGGGTCTCTA
TTCCAATGTGGCCTGTCCAGGTACAGCATTGACCAATTTGACATATGGAA
TTCTGCCTC
CGTTTATATGGACGCTGTTGATGCCGGCAATATTGCTACTTCGCTTTTTTGCAAATGCAT
T
CACTTTGACACCATATAATGGAACAGAAGCTCTGGTATGGCTTTTCCACCAAAAGCCT
GAATCTCTCAAT
CCTCTGATCAAATATCTGAGTGCCACCACTGGCTTTGGAAGAAATTA
TATTATGACCCAGAAGATGGACC
TAGATGAAGACACTGCTGAAAAATTTTATCAAAAGT
TACTGGAACTGGAAAAGCACATTAGGGTCACTAT
TCAAAAAACAGATAATCAGGCCAGG
CTCAGTGGCTCATGCCTATAA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
AF098786

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_21_Locus:
1q23

# Metabolic_Enzyme_21_SNPs:
rs1704754; rs1780010; rs1780019; rs2805053; rs1039874; rs10917598; rs4656381; rs2997871; rs1964714; rs1704753; rs2996587; rs1780012; rs1704752; rs1892125; rs2997870; rs2491094; rs2457597; rs2805056; rs9786956; rs12402864; rs11589262; rs10917597; rs2684881; rs9663079; rs2457593; rs9427412; rs1780018; rs7529094; rs2262154; rs11581847; rs7530544; rs3215683; rs1704760; rs2684877; rs7538367; rs2998105; rs11577831; rs9661994; rs2490798; rs1780011; rs1704755; rs2983957; rs2457601; rs2684875; rs2257864; rs2998104; rs2257578; rs2947613; rs12563263; rs2457624; rs12118590; rs1137574; rs2805052; rs1137576; rs1060464; rs1060466; rs1137575; rs2996593; rs2997363; rs2257867; rs4038285; rs2803853; rs41271993; rs2803875; rs2457620; rs28407183; rs2997636; rs28496676; rs2947612; rs2457623; rs2257753; rs2997868; rs4038282; rs12061476; rs4146687; rs1780017; rs28658433; rs2257574; rs2457594; rs2258232; rs12027467; rs2665498; rs2997637; rs35444310; rs2491089; rs2490878; rs34036280; rs35058037; rs4038266; rs2997633; rs12026208; rs2457588; rs2461259; rs2457622; rs2997366; rs34321369; rs28786082; rs4038286; rs2684884; rs2257752; rs4038263; rs2261522; rs28838384; rs4657230; rs2997638; rs2490873; rs28836851; rs2805055; rs2997360; rs2803882; rs4038268; rs2997866; rs28757377; rs35057012; rs11576487; rs2941411; rs4038267; rs2457587; rs2258219; rs2490877; rs11581908; rs2457621; rs2490874; rs34894082; rs12067455; rs2457595; rs2490797; rs4387160; rs2997365; rs4146688; rs7527982; rs35961178; rs34770807; rs2264620; rs2997865; rs2805054; rs4038264; rs2461258; rs2457596; rs2997361; rs2257594; rs2490880; rs2997634; rs11590943; rs2457598; rs1780013; rs12041044; rs2258222; rs1704751; rs11587814; rs34522457; rs2490876; rs2490875; rs2257597; rs4038284; rs2457619; rs2457589; rs2461257; rs2996594; rs2261528; rs2997635; rs2257866; rs4095366; rs2997867; rs28837117; rs4038265; rs4084040; rs2258297; rs2490879; rs28494776; rs2257588; rs6670180; rs2997872; rs2997869; rs2457615; rs2997364; rs2457603; rs2457607; rs2997632; rs2457600; rs2457604; rs2457608; rs2457609; rs2457602; rs1626296; rs2457599; rs2805051; rs2457605; rs2457606; rs2491090; rs12085483; rs12736939; rs1622198; rs1780000; rs2457633; rs2457635; rs2457636; rs2803872

# Metabolic_Enzyme_21_General_References:
10544267; 12975309; 12829805

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
5732

# Metabolic_Enzyme_22_Name:
UDP-glucuronosyltransferase 1-6 precursor

# Metabolic_Enzyme_22_Synonyms:
UDP- glucuronosyltransferase 1A6; UDPGT; UGT1*6; UGT1-06; UGT1.6; UGT- 1F; UGT1F; Phenol-metabolizing UDP-glucuronosyltransferase

# Metabolic_Enzyme_22_Gene_Name:
UGT1A6

# Metabolic_Enzyme_22_Protein_Sequence:
>UDPglucuronosyltransferase 16 precursor
MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVV
PEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIG
LYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEH
TFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRD
VDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHG
IVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLL
GHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSE
DLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDL
TWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_22_Number_of_Residues:
532

# Metabolic_Enzyme_22_Molecular_Weight:
60751

# Metabolic_Enzyme_22_Theoretical_pI:
8.55

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_22_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols

# Metabolic_Enzyme_22_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_22_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_22_Signals:
1-26

# Metabolic_Enzyme_22_Transmembrane_Regions:
490-506

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_22_GenBank_ID_Protein:
340141

# Metabolic_Enzyme_22_SwissProt_ID:
UD16_HUMAN (P19224)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
UGT1A6

# Metabolic_Enzyme_22_Geneatlas_id:
UGT1A6

# Metabolic_Enzyme_22_hgnc_id:
HGNC:12538

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Microsome

# Metabolic_Enzyme_22_Gene_Sequence:
>861 bp
ATGGCCTGCCTCCTTCGCTCATTTCAGAGAATTTCTGCAGGGGTTTTCTTCTTAGCACTT
TGGGGCATGGTTGTAGGTGACAAGCTGCTGGTGGTCCCTCAGGACGGAAGCCACTGGCTT
AGTATGAAGGATATAGTTGAGGTTCTCAGTGACCGGGGTCATGAGATTGTAGTGGTGGTG
CCTGAAGTTAATTTGCTTTTGAAAGAATCCAAATACTACACAAGAAAAATCTATCCAGTG
CCGTATGACCAAGAAGAGCTGAAGAACCGTTACCAATCATTTGGAAACAATCACTTTGCT
GAGCGATCATTCCTAACTGCTCCTCAGACAGAGTACAGGAATAACATGATTGTTATTGGC
CTGTACTTCATCAACTGCCAGAGCCTCCTGCAGGACAGGGACACCCTGAACTTCTTTAAG
GAGAGCAAGTTTGATGCTCTTTTCACAGACCCAGCCTTACCCTGTGGGGTGATCCTGGCT
GAGTATTTGGGCCTACCATCTGTGTACCTCTTCAGGGGTTTTCCGTGTTCCCTGGAGCAT
ACATTCAGCAGAAGCCCAGACCCTGTGTCCTACATTCCCAGGTGCTACACAAAGTTTTCA
GACCACATGACTTTTTCCCAACGAGTGGCCAACTTCCTTGTTAATTTGTTGGAGCCCTAT
CTATTTTATTGTCTGTTTTCAAAGTATGAAGAACTCGCATCAGCTGTCCTCAAGAGAGAT
GTGGATATAATCACCTTATATCAGAAGGTCTCTGTTTGGCTGTTAAGATATGACTTTGTG
CTTGAATATCCTAGGCCGGTCATGCCCAACATGGTCTTCATTGGAGGTATCAACTGTAAG
AAGAGGAAAGACTTGTCTCAG

# Metabolic_Enzyme_22_GenBank_ID_Gene:
M84130

# Metabolic_Enzyme_22_Chromosome_Location:
Not Available

# Metabolic_Enzyme_22_Locus:
Not Available

# Metabolic_Enzyme_22_SNPs:
Not Available

# Metabolic_Enzyme_22_General_References:
1339448; 3141926; 11434514; 9466822; 9429234

# Metabolic_Enzyme_22_References:
Not Available

# Metabolic_Enzyme_23_ID:
5722

# Metabolic_Enzyme_23_Name:
UDP-glucuronosyltransferase 2B15 precursor

# Metabolic_Enzyme_23_Synonyms:
UDPGT; UDPGTh-3; HLUG4

# Metabolic_Enzyme_23_Gene_Name:
UGT2B15

# Metabolic_Enzyme_23_Protein_Sequence:
>UDPglucuronosyltransferase 2B15 precursor
MSLKWTSVFLLIQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVTVLTSSA
STLVNASKSSAIKLEVYPTSLTKNDLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEY
YDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGELLAELFNIPFLYSLRFSVGYT
FEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYSEV
LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
MSSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVA
AHNLTWIQYHSLDVIAFLLACVATVIFIITKFCLFCFRKLAKKGKKKKRD

# Metabolic_Enzyme_23_Number_of_Residues:
530

# Metabolic_Enzyme_23_Molecular_Weight:
60989

# Metabolic_Enzyme_23_Theoretical_pI:
9.04

# Metabolic_Enzyme_23_GO_Classification:
Not Available

# Metabolic_Enzyme_23_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_23_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens

# Metabolic_Enzyme_23_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_23_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_23_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_23_Signals:
1-23

# Metabolic_Enzyme_23_Transmembrane_Regions:
495-515

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_23_GenBank_ID_Protein:
23955933

# Metabolic_Enzyme_23_SwissProt_ID:
UDB15_HUMAN (P54855)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
UGT2B15

# Metabolic_Enzyme_23_Geneatlas_id:
UGT2B15

# Metabolic_Enzyme_23_hgnc_id:
HGNC:12546

# Metabolic_Enzyme_23_PDB_ID:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Microsome

# Metabolic_Enzyme_23_Gene_Sequence:
>1593 bp
ATGTCTCTGAAATGGACGTCAGTCTTTCTGCTGATACAGCTCAGTTGTTACTTTAGCTCT
GGAAGCTGTGGAAAGGTGCTAGTGTGGCCCACAGAATACAGCCATTGGATAAATATGAAG
ACAATCCTGGAAGAGCTTGTTCAGAGGGGTCATGAGGTGACTGTGTTGACATCTTCGGCT
TCTACTCTTGTCAATGCCAGTAAATCATCTGCTATTAAATTAGAAGTTTATCCTACATCT
TTAACTAAAAATGATTTGGAAGATTCTCTTCTGAAAATTCTCGATAGATGGATATATGGT
GTTTCAAAAAATACATTTTGGTCATATTTTTCACAATTACAAGAATTGTGTTGGGAATAT
TATGACTACAGTAACAAGCTCTGTAAAGATGCAGTTTTGAATAAGAAACTTATGATGAAA
CTACAAGAGTCAAAGTTTGATGTCATTCTGGCAGATGCCCTTAATCCCTGTGGTGAGCTA
CTGGCTGAACTATTTAACATACCCTTTCTGTACAGTCTTCGATTCTCTGTTGGCTACACA
TTTGAGAAGAATGGTGGAGGATTTCTGTTCCCTCCTTCCTATGTACCTGTTGTTATGTCA
GAATTAAGTGATCAAATGATTTTCATGGAGAGGATAAAAAATATGATACATATGCTTTAT
TTTGACTTTTGGTTTCAAATTTATGATCTGAAGAAGTGGGACCAGTTTTATAGTGAAGTT
CTAGGAAGACCCACTACATTATTTGAGACAATGGGGAAAGCTGAAATGTGGCTCATTCGA
ACCTATTGGGATTTTGAATTTCCTCGCCCATTCTTACCAAATGTTGATTTTGTTGGAGGA
CTTCACTGTAAACCAGCCAAACCCCTGCCTAAGGAAATGGAAGAGTTTGTGCAGAGCTCT
GGAGAAAATGGTATTGTGGTGTTTTCTCTGGGGTCGATGATCAGTAACATGTCAGAAGAA
AGTGCCAACATGATTGCATCAGCCCTTGCCCAGATCCCACAAAAGGTTCTATGGAGATTT
GATGGCAAGAAGCCAAATACTTTAGGTTCCAATACTCGACTGTACAAGTGGTTACCCCAG
AATGACCTTCTTGGTCATCCCAAAACCAAAGCTTTTATAACTCATGGTGGAACCAATGGC
ATCTATGAGGCGATCTACCATGGGATCCCTATGGTGGGCATTCCCTTGTTTGCGGATCAA
CATGATAACATTGCTCACATGAAAGCCAAGGGAGCAGCCCTCAGTGTGGACATCAGGACC
ATGTCAAGTAGAGATTTGCTCAATGCATTGAAGTCAGTCATTAATGACCCTGTCTATAAA
GAGAATGTCATGAAATTATCAAGAATTCATCATGACCAACCAATGAAGCCCCTGGATCGA
GCAGTCTTCTGGATTGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTTCGAGTCGCA
GCTCACAACCTCACCTGGATCCAGTACCACTCTTTGGATGTGATAGCATTCCTGCTGGCC
TGCGTGGCAACTGTGATATTTATCATCACAAAATTTTGCCTGTTTTGTTTCCGAAAGCTT
GCCAAAACAGGAAAGAAGAAGAAAAGAGATTAG

# Metabolic_Enzyme_23_GenBank_ID_Gene:
AF548389

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_23_Locus:
4q13

# Metabolic_Enzyme_23_SNPs:
rs6825560; rs988562; rs1120265; rs1960773; rs7686914; rs988560; rs6839555; rs7682027; rs3100; rs9994887; rs1580083; rs7377952; rs7696472; rs6825748; rs13128530; rs1968719; rs1968718; rs7654523; rs1026337; rs1947435; rs1026338; rs2278917; rs1160212; rs12500760; rs4048844; rs7377954; rs12647504; rs4148271; rs2168050; rs2168051; rs6858676; rs35791822; rs13112099; rs7377950; rs34930215; rs17324486; rs5017546; rs2877378; rs1947434; rs5017549; rs17221777; rs35601514; rs6839657; rs11371462; rs5017544; rs2331421; rs2331422; rs6820752; rs4694747; rs12108552; rs34214136; rs4426857; rs35503231; rs5017548; rs35397066; rs5859136; rs2877377; rs10549990; rs2331423; rs5017545; rs34618890; rs5017547; rs5029385; rs1026339; rs5859137; rs34498614; rs34207963; rs3966095; rs1902023; rs4148269

# Metabolic_Enzyme_23_General_References:
7835232; 9295060; 2116769

# Metabolic_Enzyme_23_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7546

# Macromolecular_Interacting_Partner_1_Name:
Prolactin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
PRL

# Macromolecular_Interacting_Partner_1_Gene_Name:
PRL

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Prolactin precursor
MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN
EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG
LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
227

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
25876

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.99

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Prolactin acts primarily on the mammary gland by promoting lactation

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_1_Signals:
1-28

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
34211

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
PRL_HUMAN (P01236)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
PRL

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
PRL

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9445

# Macromolecular_Interacting_Partner_1_PDB_ID:
1RW5

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>684 bp
ATGAACATCAAAGGATCGCCATGGAAAGGGTCCCTCCTGCTGCTGCTGGTGTCAAACCTG
CTGCTGTGCCAGAGCGTGGCCCCCTTGCCCATCTGTCCCGGCGGGGCTGCCCGATGCCAG
GTGACCCTTCGAGACCTGTTTGACCGCGCCGTCGTCCTGTCCCACTACATCCATAACCTC
TCCTCAGAAATGTTCAGCGAATTCGATAAACGGTATACCCATGGCCGGGGGTTCATTACC
AAGGCCATCAACAGCTGCCACACTTCTTCCCTTGCCACCCCCGAAGACAAGGAGCAAGCC
CAACAGATGAATCAAAAAGACTTTCTGAGCCTGATAGTCAGCATATTGCGATCCTGGAAT
GAGCCTCTGTATCATCTGGTCACGGAAGTACGTGGTATGCAAGAAGCCCCGGAGGCTATC
CTATCCAAAGCTGTAGAGATTGAGGAGCAAACCAAACGGCTTCTAGAGGGCATGGAGCTG
ATAGTCAGCCAGGTTCATCCTGAAACCAAAGAAAATGAGATCTACCCTGTCTGGTCGGGA
CTTCCATCCCTGCAGATGGCTGATGAAGAGTCTCGCCTTTCTGCTTATTATAACCTGCTC
CACTGCCTACGCAGGGATTCACATAAAATCGACAATTATCTCAAGCTCCTGAAGTGCCGA
ATCATCCACAACAACAACTGCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00566

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_1_Locus:
6p22.2-p21.3

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
6260780; 6325171; 2050267; 6146607; 9266104; 925136; 1126929

# Macromolecular_Interacting_Partner_1_References:
16595727; 16706158; 16706215; 16775175

# Macromolecular_Interacting_Partner_2_ID:
7549

# Macromolecular_Interacting_Partner_2_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
INS

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_2_Signals:
1-24

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
INS

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_2_Locus:
11p15.5

# Macromolecular_Interacting_Partner_2_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_2_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_2_References:
16691383; 16728552; 16731783; 16754860

# Macromolecular_Interacting_Partner_3_ID:
7551

# Macromolecular_Interacting_Partner_3_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_3_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_3_Locus:
6p21.3

# Macromolecular_Interacting_Partner_3_SNPs:
Not Available

# Macromolecular_Interacting_Partner_3_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_3_References:
16806337; 17048691

# Macromolecular_Interacting_Partner_4_ID:
7559

# Macromolecular_Interacting_Partner_4_Name:
Estrogen receptor

# Macromolecular_Interacting_Partner_4_Synonyms:
ER; Estradiol receptor; ER-alpha

# Macromolecular_Interacting_Partner_4_Gene_Name:
ESR1

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Estrogen receptor
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
595

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
66217

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.14

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  steroid binding
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF02159:Oest_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
31620888

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
ESR1_HUMAN (P03372)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
ESR1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
ESR1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:3467

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>63 bp
ATGCGCTGCGTCGCCTCTAACCTCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTC
TGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
X03635

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_4_Locus:
6q25.1

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
3753802; 3754034; 8600466; 14574404; 10619354; 7916651; 7476978; 7539106; 1577818; 7838153; 9627117; 10428798; 10567404; 10359819; 11113208; 11971969; 12415108; 2247153; 8221895; 9338790; 9600906; 9875847; 9619507; 2792078; 8961262; 9195227

# Macromolecular_Interacting_Partner_4_References:
16609042; 16635015; 16638969; 16650618

# Macromolecular_Interacting_Partner_5_ID:
6946

# Macromolecular_Interacting_Partner_5_Name:
Sex hormone-binding globulin precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
SHBG; Sex steroid-binding protein; SBP; Testis-specific androgen-binding protein; ABP; Testosterone-estrogen-binding globulin; Testosterone-estradiol- binding globulin; TeBG

# Macromolecular_Interacting_Partner_5_Gene_Name:
SHBG

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Sex hormonebinding globulin precursor
MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMT
FDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGA
GPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPAS
NLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDI
PQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPL
VLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTS
FCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
402

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
43780

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.70

# Macromolecular_Interacting_Partner_5_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00054:Laminin_G_1

# Macromolecular_Interacting_Partner_5_Signals:
1-29

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
296673

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
SHBG_HUMAN (P04278)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
SHBG

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
SHBG

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:10839

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Secreted protein. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis (By similarity)

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1209 bp
ATGGAGAGCAGAGGCCCACTGGCTACCTCGCGCCTGCTGCTGTTGCTGCTGTTGCTACTA
CTGCGTCACACCCGCCAGGGATGGGCCCTGAGACCTGTTCTCCCCACCCAGAGTGCCCAC
GACCCTCCGGCTGTCCACCTCAGCAATGGCCCAGGACAAGAGCCTATCGCTGTCATGACC
TTTGACCTCACCAAGATCACAAAAACCTCCTCCTCCTTTGAGGTTCGAACCTGGGACCCA
GAGGGAGTGATTTTTTATGGGGATACCAACCCTAAGGATGACTGGTTTATGCTGGGACTT
CGAGACGGCAGGCCTGAGATCCAACTGCACAATCACTGGGCCCAGCTTACGGTGGGTGCT
GGACCACGGCTGGATGATGGGAGATGGCACCAGGTGGAAGTCAAGATGGAGGGGGACTCT
GTGCTGCTGGAGGTGGATGGGGAGGAGGTGCTGCGCCTGAGACAGGTCTCTGGGCCCCTG
ACCAGCAAACGCCATCCCATCATGAGGATTGCGCTTGGGGGGCTGCTCTTCCCCGCTTCC
AACCTTCGGTTGCCGCTGGTTCCTGCCCTGGATGGCTGCCTGCGCCGGGATTCCTGGCTG
GACAAACAGGCCGAGATCTCAGCATCTGCCCCCACTAGCCTCAGAAGCTGTGATGTAGAA
TCAAATCCCGGGATATTTCTCCCTCCAGGGACTCAGGCAGAATTCAATCTCCGAGACATT
CCCCAGCCTCATGCAGAGCCCTGGGCCTTCTCTTTGGACCTGGGACTCAAGCAGGCAGCA
GGCTCAGGCCACCTCCTTGCTCTTGGGACACCAGAGAACCCATCTTGGCTCAGTCTCCAC
CTCCAAGATCAAAAGGTGGTGTTGTCTTCTGGGTCGGGGCCAGGGCTGGATCTGCCCCTG
GTCTTGGGACTCCCTCTTCAGCTGAAGCTGAGTATGTCCAGGGTGGTCTTGAGCCAAGGG
TCGAAGATGAAGGCCCTTGCCCTGCCTCCCTTAGGCCTGGCTCCCCTCCTTAACCTCTGG
GCCAAGCCTCAAGGGCGTCTCTTCCTGGGGGCTTTACCAGGAGAAGACTCTTCCACCTCT
TTTTGCCTGAATGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAAC
AGAAGCCATGAGATCTGGACTCACAGCTGCCCCCAGAGCCCAGGCAATGGCACTGACGCT
TCCCATTAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
X16349

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_5_Locus:
17p13-p12

# Macromolecular_Interacting_Partner_5_SNPs:
rs6260; rs6258; rs9282845; rs6259; rs6261; rs4987212; rs9282846; rs6257; rs9913778; rs858517; rs1799941; rs858516; rs35167070; rs34865989; rs34420533; rs35338190; rs3760213; rs8065089; rs5030659; rs13894; rs1641536; rs1641537; rs1641544; rs1642800; rs2543553; rs2955617; rs34780532; rs727428; rs858520; rs858521; rs9898876

# Macromolecular_Interacting_Partner_5_General_References:
2587256; 2608061; 3569533; 2956126; 2956125; 3702459; 3542030; 1400872; 10675319; 12065592; 7714097; 10391209

# Macromolecular_Interacting_Partner_5_References:
16601122; 16691383; 16707209; 16728548

# Macromolecular_Interacting_Partner_6_ID:
7639

# Macromolecular_Interacting_Partner_6_Name:
G1/S-specific cyclin-D1

# Macromolecular_Interacting_Partner_6_Synonyms:
PRAD1 oncogene; BCL-1 oncogene

# Macromolecular_Interacting_Partner_6_Gene_Name:
CCND1

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>G1/Sspecific cyclinD1
MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRK
HAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
295

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
33729

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
4.68

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of cellular physiological process
Process:  regulation of cell cycle
Process:  regulation of progression through cell cycle
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Essential for the control of the cell cycle at the G1/S (start) transition

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF02984:Cyclin_C;
PF00134:Cyclin_N

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
35632

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
CCND1_HUMAN (P24385)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
CCND1

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
CCND1

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:1582

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>888 bp
ATGGAACACCAGCTCCTGTGCTGCGAAGTGGAAACCATCCGCCGCGCGTACCCCGATGCC
AACCTCCTCAACGACCGGGTGCTGCGGGCCATGCTGAAGGCGGAGGAGACCTGCGCGCCC
TCGGTGTCCTACTTCAAATGTGTGCAGAAGGAGGTCCTGCCGTCCATGCGGAAGATCGTC
GCCACCTGGATGCTGGAGGTCTGCGAGGAACAGAAGTGCGAGGAGGAGGTCTTCCCGCTG
GCCATGAACTACCTGGACCGCTTCCTGTCGCTGGAGCCCGTGAAAAAGAGCCGCCTGCAG
CTGCTGGGGGCCACTTGCATGTTCGTGGCCTCTAAGATGAAGGAGACCATCCCCCTGACG
GCCGAGAAGCTGTGCATCTACACCGACAACTCCATCCGGCCCGAGGAGCTGCTGCAAATG
GAGCTGCTCCTGGTGAACAAGCTCAAGTGGAACCTGGCCGCAATGACCCCGCACGATTTC
ATTGAACACTTCCTCTCCAAAATGCCAGAGGCGGAGGAGAACAAACAGATCATCCGCAAA
CACGCGCAGACCTTCGTTGCCCTCTGTGCCACAGATGTGAAGTTCATTTCCAATCCGCCC
TCCATGGTGGCAGCGGGGAGCGTGGTGGCCGCAGTGCAAGGCCTGAACCTGAGGAGCCCC
AACAACTTCCTGTCCTACTACCGCCTCACACGCTTCCTCTCCAGAGTGATCAAGTGTGAC
CCAGACTGCCTCCGGGCCTGCCAGGAGCAGATCGAAGCCCTGCTGGAGTCAAGCCTGCGC
CAGGCCCAGCAGAACATGGACCCCAAGGCCGCCGAGGAGGAGGAAGAGGAGGAGGAGGAG
GTGGACCTGGCTTGCACACCCACCGACGTGCGGGACGTGGACATCTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
X59798

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_6_Locus:
11q13

# Macromolecular_Interacting_Partner_6_SNPs:
rs3862792; rs603965; rs3212893; rs3212897; rs3212896; rs7177; rs3212895; rs678653; rs3212894; rs3212898; rs2510607; rs3212872; rs3212866; rs602652; rs647451; rs1352075; rs3918297; rs3212888; rs3212892; rs3212884; rs3212873; rs3212891; rs3918296; rs3212863; rs3212889; rs3212875; rs3212880; rs3212886; rs3212885; rs3212868; rs3212881; rs3212867; rs649392; rs3212864; rs3212876; rs3212870; rs3212887; rs3212871; rs586459; rs3212874; rs3212869; rs616294; rs3212865; rs3212877; rs3212878; rs3918298; rs3212879; rs3918301; rs3918292; rs3918295; rs3212882; rs3918299; rs34507830; rs2510467; rs34403558; rs3212862; rs3212861; rs3212859; rs3212860; rs954618; rs1944129; rs954619; rs11263523; rs2220247; rs1050971; rs1131439; rs17852153; rs3206821; rs2930976; rs11557712; rs11557585; rs34415572; rs3212883; rs12785633; rs2930978; rs34193475; rs3017617; rs3918293; rs3918302; rs3781611; rs5792483; rs3017618; rs3017620; rs3918300; rs3017621; rs646056; rs2930977; rs3212890; rs646064; rs3017619; rs7944853; rs5792482; rs3918294; rs34664419; rs2930979; rs36225065; rs36225071; rs36225395; rs36225394; rs36225068; rs36064048; rs36225067; rs36225072; rs36225070; rs36225069; rs36225064; rs36225073; rs36225396; rs3017616; rs1051062; rs1051357; rs11824610; rs11826558; rs11827026; rs12049899; rs12281701; rs12288567; rs12807461; rs1385875; rs1385876; rs1385877; rs1683847; rs1803190; rs1803191; rs1803356; rs2062445; rs2353016; rs2450254; rs2450255; rs2510459; rs2510460; rs2510461; rs2510462; rs2930975; rs3802782; rs609581; rs654240; rs655089; rs658047; rs667515; rs7116781; rs7121246; rs7178

# Macromolecular_Interacting_Partner_6_General_References:
1826542; 1833066; 1827756; 1833629; 8204893; 7687458; 8302605

# Macromolecular_Interacting_Partner_6_References:
16839579; 16980581; 17068199

# Macromolecular_Interacting_Partner_7_ID:
7007

# Macromolecular_Interacting_Partner_7_Name:
Phosphatidylinositol 3-kinase regulatory subunit alpha

# Macromolecular_Interacting_Partner_7_Synonyms:
PI3-kinase p85-subunit alpha; PtdIns-3-kinase p85-alpha; PI3K

# Macromolecular_Interacting_Partner_7_Gene_Name:
PIK3R1

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Phosphatidylinositol 3kinase regulatory subunit alpha
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH
VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
724

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
83599

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.06

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  lipid kinase activity
Function:  phosphoinositide 3-kinase activity
Function:  phosphatidylinositol 3-kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  guanyl nucleotide binding
Function:  GTP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  GTPase activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  protein complex
Component:  phosphoinositide 3-kinase complex

# Macromolecular_Interacting_Partner_7_General_Function:
Replication, recombination and repair 

# Macromolecular_Interacting_Partner_7_Specific_Function:
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00620:RhoGAP;
PF00017:SH2;
PF00018:SH3_1

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
P85A_HUMAN (P27986)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
PIK3R1

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
PIK3R1

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:8979

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
M61906

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_7_Locus:
5q13.1

# Macromolecular_Interacting_Partner_7_SNPs:
rs3730089; rs706713; rs3730090; rs3729981; rs7722222; rs3756668; rs2888323; rs3729984; rs12755; rs7702655; rs1131951; rs1043526; rs1643544; rs4016109; rs831125; rs171649; rs706714; rs251408; rs34303; rs2112208; rs895304; rs251409; rs251404; rs251399; rs1010793; rs10063119; rs2302976; rs2302975; rs6893676; rs3730082; rs34309; rs6861401; rs7733084; rs1664577; rs34301; rs10065413; rs831229; rs6876003; rs2302974; rs4122269; rs831123; rs10940160; rs10515070; rs173702; rs831122; rs6881033; rs7714169; rs3730086; rs17317833; rs3730087; rs10515074; rs6860081; rs16897511; rs3730088; rs12657050; rs7713645; rs7709243; rs6890202; rs42849; rs251402; rs6863431; rs34308; rs3815701; rs706716; rs40318; rs831121; rs3730078; rs10072475; rs1862162; rs6890176; rs12652661; rs34306; rs10515073; rs1445760; rs863818; rs1974781; rs1823023; rs17318918; rs173703; rs12659907; rs13156223; rs2161120; rs10940159; rs16897561; rs16897601; rs1819987; rs12697060; rs7716675; rs34304; rs4976156; rs16897558; rs11746842; rs12656176; rs251406; rs972634; rs1550805; rs7725370; rs173704; rs17839411; rs6863799; rs3730092; rs3730084; rs1862161; rs251410; rs6449960; rs7707370; rs994221; rs862714; rs11957103; rs2121109; rs2431166; rs10940158; rs7709991; rs6894871; rs831124; rs8192680; rs16897570; rs10940161; rs3730073; rs251405; rs16897562; rs28365970; rs6868872; rs251401; rs16897509; rs8192679; rs1946207; rs13173003; rs2431167; rs3730077; rs34300; rs34307; rs7713756; rs2121108; rs13167294; rs16897620; rs251407; rs1946208; rs3730091; rs17852841; rs34175949; rs17847317; rs10583550; rs1664558; rs41268435; rs9687541; rs17253369; rs2545411; rs7708232; rs10669997; rs1043425; rs10070142; rs34570857; rs5868531; rs7707793; rs3729983; rs35243561; rs34491401; rs7712540; rs10612198; rs10612201; rs7712126; rs5868532; rs7712114; rs34870423; rs35033772; rs33943986; rs10612200; rs2591417; rs2544847; rs1043426; rs1664560; rs34873643; rs1643545; rs9687422; rs36055833; rs9687539; rs1103100; rs1643543; rs34422073; rs3729982; rs35767695; rs34248986; rs13188418; rs251400; rs35255745; rs11285010; rs34010696; rs35510423; rs7717745; rs10577524; rs10614002; rs2591418; rs13154156; rs1611062; rs35472540; rs34305; rs6872284; rs1643556; rs11335573; rs1055643; rs9918196; rs10580592; rs861245; rs35373278; rs185179; rs34302; rs1643933; rs1643917; rs35582171; rs33965010; rs34287; rs36212686; rs11313149; rs185180; rs5868527; rs10552908; rs35213868; rs11343765; rs10579213; rs35812956; rs3049952; rs34037377; rs34027260; rs11351105; rs36121518; rs34476787; rs34330183; rs2545410; rs35893424; rs11291585; rs1819986; rs35728943; rs16897559; rs13180447; rs7732540; rs13153101; rs35800397; rs1300127; rs11349259; rs11334943; rs6872004; rs35918993; rs11308179; rs6871851; rs6872296; rs7735204; rs34157100; rs10461539; rs2591419; rs34695203; rs10036950; rs11960604; rs10611201; rs12153457; rs35508629; rs36029081; rs10055629; rs3730085; rs1643916; rs34594637; rs35918259; rs251403; rs11451948; rs35705146; rs10552907; rs10698662; rs5868528; rs7735075; rs1055644; rs34893631; rs34174926; rs34793287; rs34058255; rs5868529; rs4317277; rs11351869; rs34044740; rs11360241; rs10571324; rs862716; rs11280364; rs3730079; rs10678795; rs35929649; rs5024999; rs33968242; rs5868530; rs34063898; rs13163961; rs40056; rs35286739; rs35946831; rs34282574; rs36123886; rs13170618; rs34824771; rs34833428; rs6872690; rs10940157; rs11749932; rs11750202; rs40419; rs411751; rs450006; rs6449959; rs6872765; rs6899219; rs695166; rs706710; rs706711; rs706712; rs7701498; rs7701952; rs7723804; rs7732637; rs831227; rs9291926; rs9291927

# Macromolecular_Interacting_Partner_7_General_References:
1849461; 8628286; 7541045; 9489702; 9687533; 12359715; 12009866; 8648629; 8599763; 8962058; 11567151; 7681364; 8961927; 8670861; 9032108; 10768093

# Macromolecular_Interacting_Partner_7_References:
16971528; 17124377; 17127751

# Macromolecular_Interacting_Partner_8_ID:
7434

# Macromolecular_Interacting_Partner_8_Name:
Caspase-3 precursor

# Macromolecular_Interacting_Partner_8_Synonyms:
CASP-3; Apopain; Cysteine protease CPP32; Yama protein; CPP-32; SREBP cleavage activity 1; SCA-1[Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]

# Macromolecular_Interacting_Partner_8_Gene_Name:
CASP3

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Caspase3 precursor
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
277

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
31608

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
6.51

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  cysteine-type endopeptidase activity
Function:  caspase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00656:Peptidase_C14

# Macromolecular_Interacting_Partner_8_Signals:
None

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
EC 3.4.22.56

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
561666

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
CASP3_HUMAN (P42574)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
CASP3

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
CASP3

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:1504

# Macromolecular_Interacting_Partner_8_PDB_ID:
1CP3

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>834 bp
ATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATC
ATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGAT
TATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGA
ATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAAC
TTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATG
CGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGC
CATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACA
AACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATT
CAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGAT
GACATGGCGTGTCATAAAATACCAGTGGATGCCGACTTCTTGTATGCATACTCCACAGCA
CCTGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGT
GCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAAC
CGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAA
CAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
U13737

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_8_Locus:
4q34

# Macromolecular_Interacting_Partner_8_SNPs:
rs35578277; rs1049210; rs35566035; rs1049253; rs2720378; rs3087455; rs6948; rs4647640; rs4647610; rs4647617; rs4647642; rs4647634; rs4647611; rs4647620; rs1049216; rs4647641; rs4647618; rs4647609; rs4647694; rs8549; rs4647698; rs4647614; rs4647621; rs4647622; rs4647616; rs4647633; rs4647643; rs4647630; rs34184817; rs4647647; rs35422505; rs4647624; rs4647626; rs4647696; rs4647606; rs4647631; rs4647646; rs4647607; rs4647625; rs34022730; rs35439719; rs2720377; rs4647632; rs4647628; rs2310103; rs34309992; rs4647629; rs4647644; rs4647636; rs2019978; rs2705891; rs1830254; rs2720376; rs2696056; rs4241793; rs4647667; rs4647688; rs4647663; rs1405942; rs4647652; rs1405938; rs4647662; rs2705901; rs1405944; rs4647671; rs4647665; rs2696057; rs4647693; rs4647672; rs2705897; rs4647669; rs4647673; rs4647692; rs4647674; rs4647666; rs4647686; rs4647683; rs4647690; rs4647657; rs4987118; rs4647679; rs4647670; rs4987119; rs4647658; rs4647684; rs4647675; rs4647650; rs34319440; rs4647685; rs2696048; rs4647651; rs4647676; rs4647687; rs4647655; rs13128316; rs13435139; rs4647704; rs4647700; rs12646257; rs4647701; rs4647623; rs4647635; rs10028033; rs12641602; rs13101834; rs11380373; rs4647695; rs34119644; rs2705892; rs34858791; rs35063555; rs4647699; rs4647639; rs34095700; rs4647619; rs13102911; rs4647645; rs4647612; rs13101835; rs4647637; rs4647638; rs2705893; rs4647649; rs2696060; rs10028034; rs4647697; rs4647613; rs35978407; rs4647608; rs4647615; rs28418774; rs4647648; rs1802667; rs34568867; rs7442206; rs4647682; rs4647656; rs4647681; rs4647668; rs4647677; rs4647678; rs4647691; rs35261594; rs4647689; rs4647653; rs35966919; rs34740772; rs4647659; rs41314884; rs9997231; rs3215361; rs4647661; rs4647654; rs10014306; rs10660141; rs4647664; rs4647660; rs4647680; rs10034836; rs35094553; rs9715122; rs4647705; rs34083547; rs9715863; rs4647702; rs4647703; rs11930666; rs12108497; rs12507711; rs13108061; rs13435890; rs1405937; rs2696058; rs2696059; rs2705881; rs2705882; rs2705900; rs2720388; rs2720389; rs34605630; rs4647600; rs4647602; rs4647603; rs4647605; rs4861629; rs4862396; rs4862399; rs7673753; rs7674164; rs7687648; rs9685847

# Macromolecular_Interacting_Partner_8_General_References:
7983002; 7774019; 7596430; 8673606; 9045680; 10821855; 8755496; 8696339

# Macromolecular_Interacting_Partner_8_References:
16580805; 16621521; 16751381; 17020145

# Macromolecular_Interacting_Partner_9_ID:
5688

# Macromolecular_Interacting_Partner_9_Name:
Estrogen receptor beta

# Macromolecular_Interacting_Partner_9_Synonyms:
ER-beta

# Macromolecular_Interacting_Partner_9_Gene_Name:
ESR2

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Estrogen receptor beta
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
530

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
59217

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
8.55

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  steroid binding
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_9_Signals:
None

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
2911152

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
ESR2_HUMAN (Q92731)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
ESR2

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
ESR2

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:3468

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>1593 bp
ATGGATATAAAAAACTCACCATCTAGCCTTAATTCTCCTTCCTCCTACAACTGCAGTCAA
TCCATCTTACCCCTGGAGCACGGCTCCATATACATACCTTCCTCCTATGTAGACAGCCAC
CATGAATATCCAGCCATGACATTCTATAGCCCTGCTGTGATGAATTACAGCATTCCCAGC
AATGTCACTAACTTGGAAGGTGGGCCTGGTCGGCAGACCACAAGCCCAAATGTGTTGTGG
CCAACACCTGGGCACCTTTCTCCTTTAGTGGTCCATCGCCAGTTATCACATCTGTATGCG
GAACCTCAAAAGAGTCCCTGGTGTGAAGCAAGATCGCTAGAACACACCTTACCTGTAAAC
AGAGAGACACTGAAAAGGAAGGTTAGTGGGAACCGTTGCGCCAGCCCTGTTACTGGTCCA
GGTTCAAAGAGGGATGCTCACTTCTGCGCTGTCTGCAGCGATTACGCATCGGGATATCAC
TATGGAGTCTGGTCGTGTGAAGGATGTAAGGCCTTTTTTAAAAGAAGCATTCAAGGACAT
AATGATTATATTTGTCCAGCTACAAATCAGTGTACAATCGATAAAAACCGGCGCAAGAGC
TGCCAGGCCTGCCGACTTCGGAAGTGTTACGAAGTGGGAATGGTGAAGTGTGGCTCCCGG
AGAGAGAGATGTGGGTACCGCCTTGTGCGGAGACAGAGAAGTGCCGACGAGCAGCTGCAC
TGTGCCGGCAAGGCCAAGAGAAGTGGCGGCCACGCGCCCCGAGTGCGGGAGCTGCTGCTG
GACGCCCTGAGCCCCGAGCAGCTAGTGCTCACCCTCCTGGAGGCTGAGCCGCCCCATGTG
CTGATCAGCCGCCCCAGTGCGCCCTTCACCGAGGCCTCCATGATGATGTCCCTGACCAAG
TTGGCCGACAAGGAGTTGGTACACATGATCAGCTGGGCCAAGAAGATTCCCGGCTTTGTG
GAGCTCAGCCTGTTCGACCAAGTGCGGCTCTTGGAGAGCTGTTGGATGGAGGTGTTAATG
ATGGGGCTGATGTGGCGCTCAATTGACCACCCCGGCAAGCTCATCTTTGCTCCAGATCTT
GTTCTGGACAGGGATGAGGGGAAATGCGTAGAAGGAATTCTGGAAATCTTTGACATGCTC
CTGGCAACTACTTCAAGGTTTCGAGAGTTAAAACTCCAACACAAAGAATATCTCTGTGTC
AAGGCCATGATCCTGCTCAATTCCAGTATGTACCCTCTGGTCACAGCGACCCAGGATGCT
GACAGCAGCCGGAAGCTGGCTCACTTGCTGAACGCCGTGACCGATGCTTTGGTTTGGGTG
ATTGCCAAGAGCGGCATCTCCTCCCAGCAGCAATCCATGCGCCTGGCTAACCTCCTGATG
CTCCTGTCCCACGTCAGGCATGCGAGTAACAAGGGCATGGAACATCTGCTCAACATGAAG
TGCAAAAATGTGGTCCCAGTGTATGACCTGCTGCTGGAGATGCTGAATGCCCACGTGCTT
CGCGGGTGCAAGTCCTCCATCACGGGGTCCGAGTGCAGCCCGGCAGAGGACAGTAAAAGC
AAAGAGGGCTCCCAGAACCCACAGTCTCAGTGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
AB006590

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_9_Locus:
14q23.2

# Macromolecular_Interacting_Partner_9_SNPs:
rs1256049; rs1541060; rs1256054; rs928554; rs1271572; rs2987983; rs1952586; rs6573553; rs4986938; rs1571512; rs3020445; rs2978381; rs3020450; rs12436302; rs10137185; rs3783736; rs2357479; rs1887994; rs3020444; rs1255998; rs11625778; rs17101774; rs9788441; rs8018687; rs6573552; rs10146107; rs1256120; rs17226046; rs10146464; rs7159462; rs8011682; rs2978382; rs17226060; rs11629158; rs6573554; rs10483774; rs10136822; rs3020447; rs3020446; rs1256027; rs7146908; rs10047818; rs17226088; rs10142856; rs12432174; rs3020443; rs3829768; rs8008187; rs3020449; rs2987976; rs1256029; rs12436533; rs17179740; rs10142766; rs8019025; rs35000350; rs17226081; rs12436325; rs17101765; rs12589834; rs35142532; rs34996860; rs1256033; rs944459; rs1256044; rs1256065; rs1269056; rs1952585; rs944045; rs1256056; rs944460; rs1152577; rs1152579; rs960070; rs1256030; rs1256031; rs1152578; rs1256061; rs1256066; rs867443; rs1256037; rs1256039; rs4365213; rs944050; rs1256036; rs1256059; rs10148269; rs1256048; rs6573549; rs1256043; rs1256063; rs1256064; rs1152580; rs12432029; rs8006145; rs944461; rs8017441; rs8003490; rs1256062; rs960069; rs1256045; rs7154455; rs1256041; rs11844783; rs11850375; rs1256046; rs6573551; rs12435284; rs10144225; rs12435857; rs1256055; rs17225885; rs7151379; rs1760988; rs1256040; rs6573550; rs1152576; rs1256047; rs10143616; rs1109056; rs2274705; rs953592; rs1256038; rs1256032; rs12437103; rs8022377; rs944458; rs12435307; rs1256042; rs8021763; rs10136955; rs17101734; rs944046; rs10143846; rs10459452; rs11621314; rs8020356; rs17766755; rs4991135; rs1152581; rs1273196; rs12435278; rs1256060; rs1256052; rs7157428; rs3742614; rs17101732; rs12436020; rs8003034; rs1256050; rs35743760; rs1256053; rs1271573; rs1256034; rs944047; rs34335763; rs8004907; rs8005720; rs28560770; rs7150504; rs28533821; rs35470913; rs36101201; rs10586023; rs35977223; rs1256122; rs12878151; rs35838376; rs11849012; rs12896657; rs10142387; rs12896460; rs8012102; rs12878171; rs12896656; rs1256028; rs34279976; rs34042570; rs34379325; rs28663685; rs12878317; rs35178946; rs12434123; rs12888944; rs1256121; rs12323665; rs35444147; rs10137994; rs34259492; rs10542764; rs12878448; rs33911435; rs35524660; rs10559131; rs8020953; rs28590754; rs28440970; rs35626954; rs28791544; rs10139423; rs2738411; rs3832949; rs12880680; rs28862689; rs35325527; rs12878147; rs35415214; rs35309509; rs34365161; rs8004284; rs12896484; rs35805395; rs34422347; rs35945666; rs35000680; rs2987980; rs34187403; rs7150300; rs3783734; rs34429939; rs28858114; rs3841304; rs12892242; rs28402888; rs35866794; rs12323439; rs33938319; rs12892235; rs8014219; rs2987975; rs9788467; rs28811117; rs34974677; rs28659912; rs11325384; rs2031960; rs10628372; rs36108515; rs35006597; rs9788542; rs2978380; rs35559445; rs34837234; rs12878447; rs3783735; rs28871406; rs28435160; rs2983748; rs10564800; rs12894175; rs12893594; rs28458963; rs35491543; rs7156924; rs34515626; rs35815260; rs11444056; rs4322568; rs36105498; rs10595890; rs7152484; rs34967796; rs10691382; rs28499370; rs35078414; rs10696080; rs2026086; rs5809224; rs36099966; rs13329021; rs35749298; rs35844028; rs34059608; rs34677580; rs7493519; rs2989401; rs34656479; rs12101211; rs28418648; rs35386350; rs36116809; rs36040036; rs34160122; rs34470395; rs944049; rs11621345; rs28649584; rs7152914; rs36020117; rs4902271; rs34569310; rs11314686; rs10589699; rs1256051; rs12897137; rs7144250; rs5809219; rs2738415; rs5809225; rs34204033; rs1152602; rs34249101; rs867442; rs35340653; rs35650237; rs35350228; rs35261009; rs35044026; rs10629775; rs10557691; rs36098496; rs12894156; rs34433810; rs34478884; rs35412659; rs34972936; rs33977154; rs35308773; rs17101753; rs11851942; rs12883967; rs34136916; rs11441046; rs2776606; rs7159990; rs944048; rs7146434; rs34568139; rs34618726; rs35874406; rs4462498; rs11439683; rs10140457; rs34745821; rs35291917; rs34179608; rs5809222; rs5027281; rs10142498; rs33992698; rs2023141; rs11621342; rs17101742; rs34288779; rs3034336; rs34373341; rs11415529; rs11297817; rs12883941; rs34959266; rs4027300; rs12587432; rs28485225; rs35394904; rs34564792; rs34846309; rs8013331; rs7493535; rs1977487; rs12892916; rs5027282; rs12889431; rs34313437; rs2094914; rs34624204; rs1048312; rs1048315; rs1048350; rs1048357; rs1152582; rs1152583; rs1152584; rs1152585; rs1152588; rs1152589; rs12434245; rs12435338; rs12435395; rs1255997; rs1256112; rs1256114; rs1256116; rs13136; rs17179404; rs2236530; rs2297621; rs2772163; rs34820571; rs35315070; rs35648226; rs35700578; rs35763782; rs35831865; rs7145919; rs7229; rs8020646; rs870404; rs915057; rs9323448; rs941697; rs944051; rs944052

# Macromolecular_Interacting_Partner_9_General_References:
9473491; 9636657; 8769313; 9671811; 9685228; 10964723; 9267036; 9325313; 10681503; 11113208; 12415108

# Macromolecular_Interacting_Partner_9_References:
16596234; 16755656; 16766427; 16770010

# Macromolecular_Interacting_Partner_10_ID:
7844

# Macromolecular_Interacting_Partner_10_Name:
Insulin-like growth factor IA precursor

# Macromolecular_Interacting_Partner_10_Synonyms:
IGF-IA; Somatomedin C; Mechano growth factor; MGF

# Macromolecular_Interacting_Partner_10_Gene_Name:
IGF1

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Insulinlike growth factor IA precursor
MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD
ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS
VRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
17026

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
9.40

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
Function:  neuropeptide hormone activity
Function:  prothoracicotrophic hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_10_Signals:
1-21

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
183110

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
IGF1A_HUMAN (P01343)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
IGF1

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
IGF1

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:5464

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>462 bp
ATGGGAAAAATCAGCAGTCTTCCAACCCAATTATTTAAGTGCTGCTTTTGTGATTTCTTG
AAGGTGAAGATGCACACCATGTCCTCCTCGCATCTCTTCTACCTGGCGCTGTGCCTGCTC
ACCTTCACCAGCTCTGCCACGGCTGGACCGGAGACGCTCTGCGGGGCTGAGCTGGTGGAT
GCTCTTCAGTTCGTGTGTGGAGACAGGGGCTTTTATTTCAACAAGCCCACAGGGTATGGC
TCCAGCAGTCGGAGGGCGCCTCAGACAGGCATCGTGGATGAGTGCTGCTTCCGGAGCTGT
GATCTAAGGAGGCTGGAGATGTATTGCGCACCCCTCAAGCCTGCCAAGTCAGCTCGCTCT
GTCCGTGCCCAGCGCCACACCGACATGCCCAAGACCCAGAAGGAAGTACATTTGAAGAAC
GCAAGTAGAGGGAGTGCAGGAAACAAGAACTACAGGATGTAG

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
M14156

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_10_Locus:
12q22-q23

# Macromolecular_Interacting_Partner_10_SNPs:
rs17884626; rs3729846; rs6220; rs6219; rs5742714; rs6214; rs6216; rs5742707; rs6217; rs6222; rs3730192; rs3730205; rs5742711; rs3730204; rs5742705; rs6221; rs5742713; rs5742715; rs3730189; rs5742706; rs1063599; rs6218; rs5742700; rs6215; rs35528193; rs17881987; rs3209674; rs6212; rs3730201; rs3730190; rs5742704; rs1140655; rs17879349; rs5031032; rs978458; rs2373721; rs1019731; rs2195240; rs2288378; rs2195239; rs5742629; rs11111274; rs5742657; rs2033178; rs7314527; rs10860869; rs4764696; rs10778176; rs9989002; rs4764883; rs12310428; rs5009837; rs5742659; rs9308315; rs972936; rs5742683; rs4764886; rs10735380; rs4764887; rs7136446; rs5742632; rs7956547; rs5742692; rs17727519; rs6213; rs17880975; rs17882264; rs10047577; rs2072592; rs17879892; rs5742627; rs5742634; rs6539035; rs10860865; rs5742694; rs17032565; rs5742620; rs5742644; rs12821878; rs11831436; rs7957559; rs5742696; rs10745942; rs17032634; rs5742682; rs1520221; rs17727841; rs11829586; rs1549593; rs2195242; rs10860867; rs9651925; rs17884734; rs17884998; rs5742658; rs4764698; rs11111265; rs5742665; rs11831702; rs12305089; rs12423791; rs5742614; rs5742639; rs5742643; rs5742690; rs17885092; rs12299353; rs2162679; rs5742695; rs5742653; rs5742623; rs17032623; rs5742615; rs11837195; rs11111272; rs5742668; rs5742626; rs5742624; rs5742678; rs5742637; rs11111267; rs1520220; rs7132915; rs5742667; rs5742652; rs5742669; rs5742618; rs10778174; rs4764697; rs28682289; rs5742671; rs11111266; rs4764699; rs5742655; rs5742638; rs10778175; rs5742666; rs5742617; rs5742663; rs12833855; rs5742689; rs5742622; rs17885209; rs7300373; rs5742654; rs5742645; rs7971494; rs5742636; rs10745940; rs17796225; rs5742661; rs35996361; rs17886202; rs5742656; rs5742686; rs5742670; rs2373722; rs35524121; rs17882461; rs11111269; rs35626892; rs11111262; rs5742647; rs10860864; rs17882373; rs5742664; rs12313279; rs17884900; rs5742625; rs17878658; rs7296464; rs17879380; rs12426645; rs5742635; rs5742688; rs5742628; rs6539036; rs5742672; rs34300540; rs5742649; rs4764885; rs35897406; rs35349902; rs35209973; rs5742630; rs17882108; rs17878845; rs17885477; rs1520222; rs17886416; rs17881922; rs35437018; rs17879867; rs12316064; rs5742633; rs34291100; rs34311929; rs5742660; rs5742641; rs17878318; rs5742648; rs17884646; rs11608757; rs5742621; rs5742684; rs12425939; rs4764884; rs10860866; rs17032577; rs17878342; rs35767; rs5742722; rs5742723; rs2946834; rs11829707; rs5742720; rs5742612; rs11829693; rs2288377; rs5742716; rs3730195; rs3730193; rs35365615; rs5742702; rs3730211; rs3730224; rs5742712; rs3730210; rs4479044; rs3730207; rs5800508; rs34632512; rs17884961; rs5742698; rs3730206; rs3730203; rs35306040; rs35234844; rs3730188; rs3730226; rs17885397; rs5742703; rs5742701; rs2114911; rs3730218; rs5742708; rs3730221; rs28399924; rs35770817; rs1142050; rs3730200; rs35042457; rs1063600; rs14970; rs34621369; rs5742709; rs3032446; rs3730209; rs3730191; rs5742613; rs3730223; rs17847185; rs5742710; rs3730212; rs3730208; rs17847188; rs35359199; rs5800507; rs17886337; rs35249557; rs12817059; rs9282710; rs34903472; rs5742693; rs12299690; rs34647656; rs5742675; rs12810139; rs10745941; rs2373723; rs17879585; rs17880891; rs12320356; rs35140968; rs5800510; rs17879693; rs17882696; rs35437431; rs35174508; rs5742687; rs17885230; rs11608743; rs12368271; rs17882221; rs2373724; rs17886520; rs35775928; rs5742619; rs10860863; rs17885564; rs5742676; rs5742677; rs11421600; rs34805296; rs12816379; rs11608742; rs11111273; rs17879010; rs17886798; rs17882149; rs34599859; rs12817072; rs3032454; rs34813772; rs10860868; rs17879390; rs11111268; rs17885210; rs9282711; rs17886237; rs35222135; rs17878871; rs3729847; rs10557735; rs12320358; rs12819048; rs17878637; rs34545292; rs17882016; rs17878716; rs10614489; rs34568432; rs5742650; rs11111279; rs17881804; rs17878620; rs5742616; rs35813377; rs35403470; rs5742640; rs5742673; rs35865277; rs17879664; rs10685119; rs5742680; rs11111263; rs12314338; rs17878397; rs11111271; rs17880004; rs5742681; rs5742646; rs35004383; rs11111278; rs34817710; rs36103805; rs11111270; rs5742651; rs17881582; rs17885105; rs12816545; rs17882697; rs5742674; rs35123842; rs10161018; rs17882126; rs35993329; rs5742697; rs764911; rs11111277; rs35635523; rs12809983; rs5742631; rs1015693; rs17878818; rs12370356; rs11111276; rs35660465; rs7297946; rs11111281; rs11305762; rs34097393; rs34199594; rs5742662; rs17881697; rs36047405; rs36123817; rs4764882; rs17878303; rs36005419; rs17886265; rs17728444; rs12319588; rs17884880; rs34918171; rs11111264; rs35433913; rs5800512; rs17885262; rs17879785; rs17879563; rs17883650; rs34618338; rs34085295; rs34241965; rs17883689; rs34212937; rs17882244; rs17887104; rs34938746; rs35261849; rs12816586; rs17885578; rs17882564; rs17884984; rs17879080; rs17879837; rs12820619; rs11111280; rs12229818; rs17885158; rs5742691; rs34800889; rs12821533; rs11837097; rs5742679; rs17882237; rs12301183; rs34432139; rs17886964; rs34588740; rs5742685; rs10542027; rs35407198; rs5742642; rs17882333; rs10592539; rs5800511; rs17885342; rs35384466; rs3033405; rs12830260; rs2217241; rs3033407; rs17879774; rs35806302; rs17882374; rs5742717; rs10665874; rs5742719; rs5800513; rs7487728; rs5742718; rs17884864; rs5742721; rs10860860; rs10860861; rs10860862; rs11111259; rs11111260; rs11111261; rs11111282; rs11831864; rs12301163; rs12301559; rs12579077; rs12579108; rs1457601; rs17032483; rs17032487; rs17032648; rs2373720; rs2946831; rs2971575; rs2971577; rs35765; rs35766; rs7316439; rs7980083; rs855201; rs9919733

# Macromolecular_Interacting_Partner_10_General_References:
2937782; 6358902; 2935423; 3002851; 2018498; 1372070; 6382022; 632300; 6189745; 2036417; 1319992; 3242681; 8857020

# Macromolecular_Interacting_Partner_10_References:
17045571; 17123942; 17124377

# Macromolecular_Interacting_Partner_11_ID:
8310

# Macromolecular_Interacting_Partner_11_Name:
72 kDa type IV collagenase precursor

# Macromolecular_Interacting_Partner_11_Synonyms:
72 kDa gelatinase; Matrix metalloproteinase-2; MMP-2; Gelatinase A; TBE- 1

# Macromolecular_Interacting_Partner_11_Gene_Name:
MMP2

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>72 kDa type IV collagenase precursor
MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT
SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ
IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY
WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP
GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC


# Macromolecular_Interacting_Partner_11_Number_of_Residues:
660

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
73883

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
5.09

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  metallopeptidase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  metalloendopeptidase activity
 ||
>>>
Process:  carbohydrate metabolism
Process:  cellular carbohydrate metabolism
Process:  peptidoglycan metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  extracellular matrix
Component:  extracellular matrix (sensu Metazoa)

# Macromolecular_Interacting_Partner_11_General_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Specific_Function:
In addition to gelatin and collagens, it cleaves KiSS1 at a Gly-|-Leu bond

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF00040:fn2;
PF00045:Hemopexin;
PF00413:Peptidase_M10;
PF01471:PG_binding_1

# Macromolecular_Interacting_Partner_11_Signals:
1-29

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
EC 3.4.24.24

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
180671

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
MMP2_HUMAN (P08253)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
MMP2

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
MMP2

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:7166

# Macromolecular_Interacting_Partner_11_PDB_ID:
1GXD

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>1936 bp
CCTCTGTCTCCTGGGCTGCCTGCTGAGCCACGCCGCCGCCGCGCCGTCGCCCATCATCAA
GTTCCCCGGCGATGTCGCCCCCAAAACGGACAAAGAGTTGGCAGTGCAATACCTGAACAC
CTTCTATGGCTGCCCCAAGGAGAGCTGCAACCTGTTTGTGCTGAAGGACACACTAAAGAA
GATGCAGAAGTTCTTTGGACTGCCCCAGACAGGTGATCTTGACCAGAATACCATCGAGAC
CATGCGGAAGCCACGCTGCGGCAACCCAGATGTGGCCAACTACAACTTCTTCCCTCGCAA
GCCCAAGTGGGACAAGAACCAGATCACATACAGGATCATCGGCTACACACCTGATCTGGA
CCCAGAGACAGTGGATGATGCCTTTGCTCGTGCCTTCCAAGTCTGGAGCGATGTGACCCC
ACTGCGGTTTTCTCGAATCCATGATGGAGAGGCAGACATCATGATCAACTTTGGCCGCTG
GGAGCATGGCGATGGATACCCCTTTGACGGTAAGGACGGACTCCTGGCTCATGCCTTCGC
CCCAGGCACTGGTGTTGGGGGAGACTCCCATTTTGATGACGATGAGCTATGGACCTTGGG
AGAAGGCCAAGTGGTCCGTGTGAAGTATGGGAACGCCGATGGGGAGTACTGCAAGTTCCC
CTTCTTGTTCAATGGCAAGGAGTACAACAGCTGCACTGATACTGGCCGCAGCGATGGCTT
CCTCTGGTGCTCCACCACCTACAACTTTGAGAAGGATGGCAAGTACGGCTTCTGTCCCCA
TGAAGCCCTGTTCACCATGGGCGGCAACGCTGAAGGACAGCCCTGCAAGTTTCCATTCCG
CTTCCAGGGCACATCCTATGACAGCTGCACCACTGAGGGCCGCACGGATGGCTACCGCTG
GTGCGGCACCACTGAGGACTACGACCGCGACAAGAAGTATGGCTTCTGCCCTGAGACCGC
CATGTCCACTGTTGGTGGGAACTCAGAAGGTGCCCCCTGTGTCTTCCCCTTCACTTTCCT
GGGCAACAAATATGAGAGCTGCACCAGCGCCGGCCGCAGTGACGGAAAGATGTGGTGTGC
GACCACAGCCAACTACGATGACGACCGCAAGTGGGGCTTCTGCCCTGACCAAGGGTACAG
CCTGTTCCTCGTGGCAGCCCACGAGTTTGGCCACGCCATGGGGCTGGAGCACTCCCAAGA
CCCTGGGGCCCTGATGGCACCCATTTACACCTACACCAAGAACTTCCGTCTGTCCCAGGA
TGACATCAAGGGCATTCAGGAGCTCTATGGGGCCTCTCCTGACATTGACCTTGGCACCGG
CCCCACCCCCACACTGGGCCCTGTCACTCCTGAGATCTGCAAACAGGACATTGTATTTGA
TGGCATCGCTCAGATCCGTGGTGAGATCTTCTTCTTCAAGGACCGGTTCATTTGGCGGAC
TGTGACGCCACGTGACAAGCCCATGGGGCCCCTGCTGGTGGCCACATTCTGGCCTGAGCT
CCCGGAAAAGATTGATGCGGTATACGAGGCCCCACAGGAGGAGAAGGCTGTGTTCTTTGC
AGGGAATGAATACTGGATCTACTCAGCCAGCACCTTGGAGCGAGGGTACCCCAAGCCACT
GACCAGCCTGGGACTGCCCCCTGATGTCCAGCGAGTGGATGCCGCCTTTAACTGGAGCAA
AAACAAGAAGACATACATCTTTGCTGGAGACAAATTCTGGAGATACAATGAGGTGAAGAA
GAAAATGGATCCTGGCTTCCCCAAGCTCATCGCAGATGCCTGGAATGCCATCCCCGATAA
CCTGGATGCCGTCGTGGACCTGCAGGGCGGCGGTCACAGCTACTTCTTCAAGGGTGCCTA
TTACCTGAAGCTGGAGAACCAAAGTCTGAAGAGCGTGAAGTTTGGAAGCATCAAATCCGA
CTGGCTAGGCTGCTGA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
J03210

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_11_Locus:
16q13-q21

# Macromolecular_Interacting_Partner_11_SNPs:
rs16955280; rs243849; rs1053605; rs10775332; rs1132896; rs11541998; rs2287074; rs16955236; rs2052264; rs7201; rs17860019; rs2287073; rs17860021; rs15142; rs1799818; rs1477017; rs243832; rs243839; rs243844; rs243842; rs243834; rs243840; rs11640428; rs1030869; rs243836; rs837546; rs837547; rs183112; rs2287076; rs243837; rs1992116; rs243846; rs857403; rs866770; rs243845; rs243841; rs857402; rs243833; rs243835; rs9928731; rs243847; rs1030870; rs12923011; rs9302671; rs9939185; rs9936955; rs1992115; rs243862; rs8055959; rs243843; rs243838; rs1946773; rs865094; rs6499763; rs12598301; rs12934241; rs17860007; rs17859880; rs17859912; rs9923304; rs17859930; rs11076101; rs17859885; rs17859977; rs16955243; rs1030868; rs17860008; rs2241145; rs16955212; rs17859898; rs17859990; rs12599775; rs16955228; rs17859925; rs11639960; rs17859937; rs17860013; rs16955224; rs2287075; rs708269; rs17859886; rs17859974; rs17859889; rs17859882; rs17859958; rs17859975; rs16955268; rs17243002; rs11863252; rs2241146; rs17859910; rs171498; rs16955260; rs11646643; rs17859841; rs7184360; rs17301608; rs17242473; rs17859942; rs17859859; rs17859956; rs9923164; rs17859866; rs243848; rs17859878; rs17859934; rs17859978; rs16955273; rs17859994; rs17859908; rs17859927; rs17859894; rs17859991; rs17859950; rs17859867; rs17859881; rs171497; rs17859913; rs17859871; rs17859890; rs17859976; rs17859968; rs17859920; rs17859855; rs17859856; rs17859837; rs17859989; rs17859972; rs17859851; rs17859940; rs17859992; rs17859979; rs17859853; rs17859922; rs17860010; rs17859865; rs17859993; rs17860017; rs17859854; rs17859995; rs17859919; rs17859997; rs17859838; rs243831; rs11865501; rs243866; rs243865; rs243830; rs2052265; rs17859817; rs17859819; rs2285052; rs17859829; rs17859816; rs17859821; rs243864; rs2285053; rs17859827; rs41459945; rs11542001; rs17859943; rs243863; rs28730814; rs41503347; rs41513346; rs41521545; rs1063977; rs1063976; rs35646586; rs1799839; rs1058373; rs1063978; rs41280909; rs17860023; rs1799840; rs11541999; rs187228; rs36115725; rs17859832; rs17860024; rs8059615; rs17859844; rs17859873; rs17859839; rs17859843; rs17859911; rs17860011; rs3996855; rs10625273; rs28392975; rs17859884; rs17859905; rs17860000; rs865095; rs17859914; rs7206229; rs17859902; rs17859845; rs17859874; rs34939163; rs17860012; rs17860009; rs34264316; rs17859932; rs41280907; rs17859893; rs12919236; rs17859973; rs17860002; rs17859840; rs17859901; rs35129615; rs35420043; rs12445370; rs17859903; rs35909165; rs34621950; rs17859951; rs17859875; rs17859870; rs17859847; rs35367564; rs34123566; rs17859896; rs17859895; rs17859959; rs17859963; rs17859964; rs17859948; rs17859933; rs17860014; rs28730813; rs17859891; rs12919779; rs35887028; rs12922542; rs17859980; rs17859998; rs17859929; rs17860015; rs17859924; rs17859835; rs10670193; rs8054776; rs17859971; rs17859961; rs17859868; rs34871383; rs17859999; rs9932439; rs17859960; rs17859857; rs17859909; rs35242322; rs28730812; rs35472030; rs17859869; rs17859858; rs17859981; rs3214373; rs5817013; rs33937239; rs10548685; rs34036359; rs17859831; rs17859823; rs34377253; rs41400448; rs17860025; rs17859830; rs17859826; rs17859813; rs17859815; rs34814653; rs17859828; rs17860027; rs17859824; rs17859820; rs1005912; rs1005913; rs11076099; rs11076102; rs1116195; rs11643630; rs11861520; rs11865658; rs12373066; rs12446205; rs12599478; rs12599483; rs12708952; rs12918208; rs12930259; rs1347653; rs1362399; rs1561219; rs1561220; rs1583585; rs1583587; rs16955194; rs16955289; rs17302903; rs1861319; rs1861320; rs2192852; rs2192853; rs2241148; rs243828; rs243829; rs2859482; rs4454968; rs4454969; rs4454970; rs4627342; rs7189232; rs8054459; rs9922534

# Macromolecular_Interacting_Partner_11_General_References:
2834383; 1851724; 2162831; 2158484; 12879005; 7583664; 8549817

# Macromolecular_Interacting_Partner_11_References:
17010202; 17031577

# Macromolecular_Interacting_Partner_12_ID:
7936

# Macromolecular_Interacting_Partner_12_Name:
Apoptosis regulator Bcl-2

# Macromolecular_Interacting_Partner_12_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_12_Gene_Name:
BCL2

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Apoptosis regulator Bcl2
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
239

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
26266

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
7.32

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of cellular physiological process
Process:  regulation of programmed cell death
Process:  regulation of apoptosis
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF00452:Bcl-2;
PF02180:BH4

# Macromolecular_Interacting_Partner_12_Signals:
None

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
212-233

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
179367

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
BCL2_HUMAN (P10415)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
BCL2

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
BCL2

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:990

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass membrane protein. Nucleus; nuclear membrane; single- pass membrane protein. Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>720 bp
ATGGCGCACGCTGGGAGAACGGGGTACGACAACCGGGAGATAGTGATGAAGTACATCCAT
TATAAGCTGTCGCAGAGGGGCTACGAGTGGGATGCGGGAGATGTGGGCGCCGCGCCCCCG
GGGGCCGCCCCCGCACCGGGCATCTTCTCCTCCCAGCCCGGGCACACGCCCCATCCAGCC
GCATCCCGCGACCCGGTCGCCAGGACCTCGCCGCTGCAGACCCCGGCTGCCCCCGGCGCC
GCCGCGGGGCCTGCGCTCAGCCCGGTGCCACCTGTGGTCCACCTGGCCCTCCGCCAAGCC
GGCGACGACTTCTCCCGCCGCTACCGCGGCGACTTCGCCGAGATGTCCAGCCAGCTGCAC
CTGACGCCCTTCACCGCGCGGGGACGCTTTGCCACGGTGGTGGAGGAGCTCTTCAGGGAC
GGGGTGAACTGGGGGAGGATTGTGGCCTTCTTTGAGTTCGGTGGGGTCATGTGTGTGGAG
AGCGTCAACCGGGAGATGTCGCCCCTGGTGGACAACATCGCCCTGTGGATGACTGAGTAC
CTGAACCGGCACCTGCACACCTGGATCCAGGATAACGGAGGCTGGGATGCCTTTGTGGAA
CTGTACGGCCCCAGCATGCGGCCTCTGTTTGATTTCTCCTGGCTGTCTCTGAAGACTCTG
CTCAGTTTGGCCCTGGTGGGAGCTTGCATCACCCTGGGTGCCTATCTGAGCCACAAGTGA


# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
M13994

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:18

# Macromolecular_Interacting_Partner_12_Locus:
18q21.33|18q21.3

# Macromolecular_Interacting_Partner_12_SNPs:
rs1800477; rs1801018; rs1564483; rs1016860; rs4987853; rs4987861; rs4987843; rs4987852; rs3744935; rs4987864; rs4987856; rs4987854; rs4987855; rs4987846; rs4987851; rs4987858; rs4987850; rs4987859; rs4987865; rs4987845; rs4987869; rs3744937; rs4987847; rs1473418; rs4987867; rs720321; rs1383596; rs1944419; rs1531697; rs2046136; rs1545812; rs1481031; rs2332673; rs726510; rs899968; rs2062011; rs2850763; rs1381548; rs949037; rs2156192; rs2850761; rs7226979; rs1009726; rs4940576; rs2850762; rs6567334; rs2551397; rs2849377; rs2199937; rs4987792; rs11872403; rs11152377; rs4941195; rs4941183; rs2156190; rs2062010; rs8094489; rs11152375; rs12606418; rs8083946; rs726511; rs3810027; rs1542578; rs8094651; rs1462129; rs4941189; rs4941192; rs3810031; rs3943258; rs8088662; rs8096380; rs4940573; rs7228914; rs11661511; rs7240326; rs2156193; rs8086404; rs6567336; rs2849381; rs8094315; rs11876772; rs4987790; rs11152370; rs4987752; rs4940575; rs4456611; rs1893506; rs2046135; rs12457700; rs8088100; rs7242402; rs11661497; rs4940572; rs1944420; rs9955190; rs1944422; rs12454650; rs1977971; rs8089331; rs2850758; rs2046137; rs1573493; rs8084922; rs8089538; rs4987802; rs6567328; rs8095050; rs2156191; rs2849380; rs1481032; rs11875184; rs1807999; rs9807663; rs4940574; rs7230053; rs1982674; rs12457170; rs4941188; rs1344229; rs7234941; rs6567327; rs11152374; rs11152372; rs9965844; rs6567326; rs7239838; rs9962222; rs9959874; rs4940571; rs2187162; rs4987819; rs2051423; rs3810028; rs899966; rs4987739; rs6567329; rs4941185; rs4987718; rs10503079; rs8098548; rs3744933; rs3744948; rs17070798; rs4987760; rs8098848; rs4987788; rs7243201; rs4941187; rs12968517; rs4987772; rs4987722; rs4987803; rs731014; rs3744951; rs1982673; rs4987736; rs17070904; rs6567330; rs11659758; rs2850760; rs9967405; rs8099575; rs17757981; rs9630855; rs4987786; rs12454712; rs12457893; rs4987724; rs8099140; rs12970840; rs4987778; rs4987831; rs4987829; rs1026825; rs12458289; rs9972995; rs10503077; rs6567325; rs4987823; rs4987765; rs4987726; rs4987757; rs11152371; rs12605881; rs4987746; rs11875971; rs4987827; rs12961976; rs4987795; rs4987797; rs899965; rs7244617; rs1531695; rs9962656; rs12457831; rs11872329; rs4987838; rs4941184; rs2051424; rs2615200; rs7242542; rs8094630; rs7236090; rs6567324; rs7231914; rs1893806; rs4987768; rs17070959; rs1005793; rs8085707; rs17070739; rs11875686; rs17679032; rs4987721; rs4987808; rs765102; rs8097624; rs3744950; rs4987801; rs1009725; rs6567335; rs17070848; rs17685559; rs956572; rs12961672; rs11663275; rs744569; rs4987764; rs12457190; rs4941186; rs17070861; rs4941194; rs4987835; rs2170294; rs4987755; rs6567331; rs4987841; rs4987737; rs9959983; rs768058; rs7243091; rs8095077; rs4987725; rs4987733; rs17756073; rs11877475; rs8093973; rs4987839; rs4987759; rs4987783; rs960804; rs4987743; rs4987779; rs10503078; rs17757541; rs899964; rs7230970; rs4987716; rs7232625; rs9951943; rs9958550; rs8092560; rs4941190; rs12457371; rs4987828; rs3826622; rs8096471; rs8083727; rs4987821; rs2849382; rs9962051; rs17756365; rs17070913; rs8087120; rs2170295; rs4987810; rs6567332; rs899967; rs4987774; rs1381546; rs10460157; rs11873429; rs4987826; rs4987798; rs1473435; rs7242904; rs4987809; rs7242501; rs4987800; rs7232512; rs12957119; rs10164240; rs4987742; rs3948977; rs4987719; rs12458944; rs4987796; rs7231901; rs17678177; rs8099218; rs2551399; rs4987770; rs4987825; rs17070714; rs4987781; rs12962644; rs4987812; rs12963263; rs4987834; rs4987747; rs4987767; rs17758695; rs9963148; rs17841945; rs4987744; rs9959769; rs12457361; rs9946649; rs4987794; rs11152373; rs11872297; rs17070779; rs4987728; rs12963776; rs12958785; rs17686373; rs1976005; rs12457841; rs8092884; rs7240319; rs9946637; rs9961642; rs17759096; rs11877911; rs4987773; rs1944421; rs2170296; rs11877925; rs9961796; rs7230177; rs4987715; rs4987732; rs17070777; rs11874082; rs9965829; rs4987761; rs17758456; rs17062654; rs4987789; rs4987771; rs17070827; rs17758816; rs7232082; rs11661184; rs12962650; rs3842401; rs8098586; rs17678294; rs17677569; rs17070818; rs954954; rs9957149; rs1541298; rs4987717; rs9962421; rs17070841; rs4987730; rs8097918; rs8089306; rs12967026; rs7236202; rs4987750; rs17685987; rs2840358; rs4987787; rs4987780; rs17841946; rs4987723; rs7237139; rs1481030; rs12454618; rs12968867; rs9966563; rs17070877; rs17070809; rs9958905; rs6567333; rs3810030; rs4987741; rs12964150; rs9972996; rs7245234; rs1381547; rs17756248; rs4987807; rs12604822; rs17070735; rs17756266; rs4987824; rs12456572; rs2850755; rs17070943; rs4987749; rs17070946; rs17759659; rs12605858; rs4987791; rs4987815; rs9962963; rs3927911; rs8091529; rs4987822; rs8085473; rs4987731; rs17758403; rs4987745; rs4987818; rs9965425; rs4987793; rs1541295; rs4987832; rs12455492; rs4987720; rs4987817; rs2849379; rs17070750; rs4987830; rs4987873; rs2448799; rs8087606; rs4987872; rs2279115; rs41301945; rs5825508; rs2078303; rs4987849; rs17070680; rs41306972; rs34741396; rs4987866; rs34360708; rs34883036; rs1050618; rs34811186; rs4987707; rs4987868; rs4987844; rs4987862; rs34223591; rs4987842; rs4987870; rs4987848; rs4987710; rs4987860; rs34143126; rs4987706; rs3744936; rs4987863; rs4987857; rs11351478; rs35558540; rs36046351; rs34986306; rs11384331; rs12327138; rs34592237; rs34479040; rs35443488; rs35735146; rs4987738; rs35954402; rs9953797; rs11286497; rs34714510; rs34470267; rs2127872; rs34356346; rs10597397; rs7230110; rs5825509; rs4987769; rs11346802; rs35765197; rs35992365; rs28744646; rs35421280; rs7242051; rs7230703; rs3216124; rs11878084; rs3833192; rs9320014; rs34032861; rs10536242; rs28613776; rs35702853; rs35957660; rs11877270; rs36089071; rs11411155; rs34999271; rs28603232; rs8099362; rs11424742; rs34128466; rs4987740; rs36230193; rs35775563; rs34585115; rs9944895; rs4987754; rs34926393; rs35844118; rs4987753; rs4987763; rs9949240; rs4987751; rs7242531; rs11421019; rs28669125; rs28550381; rs28502762; rs28662060; rs34092929; rs28702921; rs35942763; rs35275357; rs35195646; rs2332672; rs7232179; rs11381388; rs34385891; rs34140806; rs28460613; rs2187163; rs35366804; rs28699603; rs4384687; rs35180138; rs12958555; rs4987713; rs4987805; rs35063180; rs28564323; rs9959358; rs4987837; rs596876; rs4987799; rs4987814; rs34360704; rs34927632; rs36074022; rs7232529; rs4987840; rs4987813; rs34603960; rs34737549; rs34810572; rs4987782; rs12956558; rs34724235; rs35832816; rs11396022; rs4987734; rs35916533; rs11426842; rs34422779; rs35788320; rs7243686; rs34269955; rs34821656; rs34331087; rs4987735; rs2615199; rs7245040; rs28537871; rs34628711; rs34530559; rs34280008; rs9946231; rs34246997; rs35618914; rs7504762; rs11285614; rs9955851; rs4987784; rs12454033; rs35117243; rs4987833; rs35832711; rs11876939; rs4987711; rs2085958; rs4987776; rs4987816; rs11271834; rs9807796; rs34929825; rs2849378; rs34498028; rs8094130; rs34272291; rs8089583; rs5825512; rs35786465; rs11437030; rs3810029; rs10560567; rs34392530; rs11875445; rs36010160; rs33935449; rs1870863; rs11874495; rs28566629; rs35829205; rs10604257; rs12327294; rs4987758; rs11407054; rs34122166; rs35501583; rs12454460; rs34597011; rs34215080; rs11664592; rs11330056; rs11348997; rs4987762; rs11346034; rs641060; rs35852603; rs34970907; rs7238198; rs35043985; rs10640757; rs35621103; rs34019962; rs4987820; rs11333396; rs12326606; rs11269260; rs36107927; rs34843082; rs35457535; rs12969008; rs10564352; rs4987748; rs35869219; rs1273018; rs28417258; rs17070962; rs34520768; rs34167266; rs34372247; rs34877412; rs1138828; rs12962685; rs12955832; rs28588396; rs12958518; rs33983598; rs4411604; rs2849374; rs8089784; rs1679896; rs12956104; rs35051109; rs28552905; rs3744949; rs34724758; rs7230557; rs4987811; rs34616260; rs34660120; rs34455531; rs7231840; rs4987766; rs11343409; rs11377778; rs11282101; rs11663364; rs12327297; rs12957272; rs34096346; rs12954887; rs35880134; rs8097683; rs7245041; rs11152376; rs11307145; rs11389759; rs34302549; rs35608542; rs34601248; rs35378587; rs34971240; rs7239903; rs4987727; rs34857794; rs34026129; rs36077676; rs34008827; rs11289698; rs28552745; rs35997590; rs36078664; rs10688243; rs35024611; rs35764546; rs34513836; rs34355655; rs720849; rs10718817; rs36027128; rs8092584; rs4987756; rs35555671; rs7242090; rs35771638; rs1789627; rs1271892; rs7236823; rs4987785; rs4987714; rs1462128; rs35032484; rs12605689; rs7239542; rs4941193; rs10537349; rs12970504; rs10642228; rs35689542; rs11393921; rs12962313; rs4987836; rs36095867; rs35696527; rs34059678; rs35046846; rs34022610; rs5825511; rs35369252; rs34870728; rs34960660; rs7244494; rs36099507; rs35770276; rs35956166; rs12964435; rs28562101; rs34051656; rs11271898; rs4987804; rs4987729; rs7231259; rs35818172; rs34831717; rs28464692; rs4987777; rs34298527; rs7504665; rs35161404; rs5825510; rs35593106; rs35291046; rs7230565; rs34430054; rs8098774; rs34875078; rs34683668; rs28484798; rs1531696; rs34596364; rs11399943; rs4987712; rs28431965; rs765479; rs34457708; rs36088248; rs12958359; rs2516293; rs34174534; rs35525138; rs2551400; rs35834230; rs4987705; rs4987871; rs2448798; rs2472571; rs35953169; rs34619379; rs10460159; rs11660715; rs17070659; rs17676919; rs17676949; rs17749561; rs1944423; rs2051422; rs2448800; rs2448804; rs2448805; rs2448806; rs2472572; rs2472574; rs2472576; rs2472577; rs2472578; rs2472579; rs2472581; rs2551402; rs2551404; rs2551405; rs2850764; rs698708; rs7243985; rs8086644; rs8094041; rs8099294; rs9320013; rs9945794; rs9957746; rs9989529

# Macromolecular_Interacting_Partner_12_General_References:
3523487; 1508712; 2875799; 2834197; 3285301; 1339299; 2250705; 8183370; 9395403; 8668206; 11368354; 10567572; 11463391; 12901880

# Macromolecular_Interacting_Partner_12_References:
16598173; 17138646

# Macromolecular_Interacting_Partner_13_ID:
8081

# Macromolecular_Interacting_Partner_13_Name:
Leptin precursor

# Macromolecular_Interacting_Partner_13_Synonyms:
Obesity factor; Obese protein

# Macromolecular_Interacting_Partner_13_Gene_Name:
LEP

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Leptin precursor
MHWGTLCGFLWLWPYLFYVQAVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGL
DFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLP
WASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
167

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
18641

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
6.34

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF02024:Leptin

# Macromolecular_Interacting_Partner_13_Signals:
1-21

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
623332

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
LEP_HUMAN (P41159)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
LEP

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
LEP

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:6553

# Macromolecular_Interacting_Partner_13_PDB_ID:
1AX8

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>504 bp
ATGCATTGGGGAACCCTGTGCGGATTCTTGTGGCTTTGGCCCTATCTTTTCTATGTCCAA
GCTGTGCCCATCCAAAAAGTCCAAGATGACACCAAAACCCTCATCAAGACAATTGTCACC
AGGATCAATGACATTTCACACACGCAGTCAGTCTCCTCCAAACAGAAAGTCACCGGTTTG
GACTTCATTCCTGGGCTCCACCCCATCCTGACCTTATCCAAGATGGACCAGACACTGGCA
GTCTACCAACAGATCCTCACCAGTATGCCTTCCAGAAACGTGATCCAAATATCCAACGAC
CTGGAGAACCTCCGGGATCTTCTTCACGTGCTGGCCTTCTCTAAGAGCTGCCACTTGCCC
TGGGCCAGTGGCCTGGAGACCTTGGACAGCCTGGGGGGTGTCCTGGAAGCTTCAGGCTAC
TCCACAGAGGTGGTGGCCCTGAGCAGGCTGCAGGGGTCTCTGCAGGACATGCTGTGGCAG
CTGGACCTCAGCCCTGGGTGCTGA

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
U18915

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_13_Locus:
7q31.3

# Macromolecular_Interacting_Partner_13_SNPs:
rs17151919; rs13306517; rs28954113; rs11763517; rs4731426; rs10954173; rs11761556; rs4731427; rs2167270; rs7791621; rs10257175; rs12706832; rs11760956; rs7795794; rs28954116; rs11978419; rs10244329; rs17151922; rs2278814; rs28959471; rs10954174; rs4236625; rs7796202; rs28954117; rs28959470; rs28954095; rs28954101; rs28954086; rs28954099; rs28959468; rs3750034; rs28954093; rs2278815; rs2122627; rs28954379; rs28959474; rs28954082; rs41457646; rs28954114; rs28954096; rs28959476; rs28954084; rs28954102; rs28954100; rs2060713; rs28954090; rs28954098; rs28954105; rs28954118; rs11980266; rs28954091; rs12706831; rs28959475; rs28954094; rs28954083; rs28756049; rs11973652; rs3793162; rs17151913; rs17151914; rs6956510; rs2071045; rs3828942; rs7788818; rs10264361; rs28954109; rs28954110; rs28954108; rs28954111; rs791616; rs28954376; rs28954081; rs6976701; rs10262600; rs28954369; rs28954080; rs28954371; rs34104384; rs4728096; rs791620; rs28954372; rs28954373; rs28954375; rs35048003; rs28959478; rs10258300; rs12536535; rs28954378; rs13228377; rs1800564; rs1800583; rs28954097; rs11380467; rs35394014; rs28959469; rs10676401; rs28954106; rs1031340; rs28954115; rs1349398; rs34219283; rs28959472; rs28954088; rs10243710; rs6966536; rs28954104; rs10620014; rs34457895; rs13306516; rs33910507; rs28954107; rs41526944; rs41434248; rs28954087; rs34728887; rs28954103; rs28959473; rs41528456; rs17617757; rs28954089; rs28954092; rs34052732; rs10277407; rs28954112; rs41474844; rs13306518; rs35447711; rs34046133; rs36212573; rs28959477; rs36219262; rs791618; rs28954370; rs791619; rs34669250; rs10598051; rs28954377; rs36219261; rs28391558; rs791617; rs28954374; rs36219260; rs10249476; rs10264838; rs10276311; rs10487506; rs10954175; rs10954176; rs11770725; rs12535708; rs12535747; rs12537573; rs13245201; rs1349419; rs1376268; rs16871960; rs17151895; rs2060715; rs2167271; rs35854831; rs4731423; rs4731424; rs4731428; rs4731429; rs4731430; rs6949498; rs712722; rs7778154; rs7782257; rs7798338; rs7799039; rs7801674; rs7802530; rs791604; rs791606; rs791607; rs791608; rs791610; rs791611; rs791612; rs791613; rs791614; rs791615

# Macromolecular_Interacting_Partner_13_General_References:
7984236; 7789654; 8626726; 7499240; 8621021; 10428856; 9166907; 9144295; 9500540

# Macromolecular_Interacting_Partner_13_References:
16824445; 17020145; 17043388

# Macromolecular_Interacting_Partner_14_ID:
8202

# Macromolecular_Interacting_Partner_14_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_14_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_14_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_14_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_14_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_14_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_14_Pathway:
Not Available

# Macromolecular_Interacting_Partner_14_Reaction:
Not Available

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_14_Signals:
None

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_14_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_14_Locus:
10q22

# Macromolecular_Interacting_Partner_14_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_14_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_14_References:
17010202

End of HMDB00151

Beginning of HMDB00152
# Accession_No:
HMDB00152

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-05-23 13:59:45

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Gentisic acid

# Description:
Gentisic acid is a dihydroxybenzoic acid.  It is a crystalline powder that forms monoclinic prism in water solution. Gentisic acid is an active metabolite of salicylic acid degradation. There is an increasing amount of evidence indicating that gentisic acid has a broad spectrum of biological activity, such as anti-inflammatory, antirheumatic and antioxidant properties.  Gentisic acid is also a byproduct of tyrosine and benzoate metabolism.

# Synonyms:
2,5-Dihydroxybenzoate; 2,5-Dihydroxybenzoic acid; 2,5-Dioxybenzoate; 2,5-Dioxybenzoic acid; 3,6-Dihydroxybenzoate; 3,6-Dihydroxybenzoic acid; 5-Hydroxysalicylate; 5-Hydroxysalicylic acid; 5-hydroxy-Salicylate; 5-hydroxy-Salicylic acid; Carboxyhydroquinone; Dihydroxybenzoicacid; Gensigen; Gensigon; Gentisate; Gentisic acid; Gentisinate; Gentisinic acid; Hydroquinonecarboxylate; Hydroquinonecarboxylic acid

# Chemical_IUPAC_Name:
2,5-dihydroxybenzoic acid

# Chemical_Formula:
C7H6O4

# Chemical_Structure:
tbl_chemical:::HMDB00152_ZOOM.png:::119283220809224573

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00152_THUMB.png:::119283220650192994

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
phenol or hydroxyhetarene; carboxylic acid; aromatic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
154.02661

# Molecular_Weight_Avg:
154.12015

# Smiles_String_isomeric:
OC(=O)C1=CC(O)=CC=C1O

# Smiles_String_canonical:
OC(=O)C1=CC(O)=CC=C1O

# KEGG_Compound_ID:
C00628

# BioCyc_ID:
Not Available

# PubChem_CID:
3469

# PubChem_SID:
11335713; 11448430; 8152205; 87799; 11495055; 153543; 10523981; 3136489; 11366697; 11364135; 11484582; 11377421; 11360952; 11372370; 611429; 598677; 3901; 11375621; 101400; 11461924; 11488589; 11491141; 4652585; 551256; 8149154; 8143659; 588529; 11493635; 539429; 10410247; 7988977; 11369259

# OMIM_ID:
Not Available

# Metagene_ID:
ALKAPTONURIA. HOMOGENTISIC ACID OXIDASE DEFICIENCY: 53

# BiGG_ID:
Not Available

# Wikipedia_ID:
Gentisic acid

# METLIN_ID:
618

# Ref_ID:
8364451; 9208249; 3378323; 8833980; 3026319; 8590024; 7074905; 8634769; 7668368; 7249509; 7356541

# ChEBI_ID:
17189

# CAS_Registry_Number:
490-79-9

# InChI:
InChI=1/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)

# Synthesis_Reference:
Preparation of gentisic acid and its fatty alcohol esters.     Morris, Steward G.    Journal of the American Chemical Society  (1949),  71  2056-7

# Melting_Point:
199.5 oC

# Melting_Point_predicted:
107.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
5.0 mg/mL at 5 oC [MERCK (1989)]

# H2O_Solubility_Predicted:
12.3 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
1.74 [SANGSTER (1994)]

# LogP_predicted:
1.23 [Predicted by ALOGPS]; 1.386 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Gentisic acid.pdf:::1132562206999974003

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Gentisic_acid.mol:::1132723810328254271

# SDF_File_[Text]:
tbl_chemical:::HMDB00152.sdf:::119283220352195735

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00152.pdb:::119283220511547342

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041020_P00_02_HW_1DP_presat.png:::114849922642377083

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041020_P00_02_HW_1DP_presat.zip:::114849922642913137

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041020_P00_02_HW_1DP_Assigned.png:::115679834107641429

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041020_P00_02_HW_2DHSQC_694.png:::114789998499843306

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041020_P00_02_HW_2DHSQC_694.zip:::114789998500449390

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041020_P00_02_HW_2DHSQC_694_Assigned.png:::116283782795792419

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Gentisic acid.gif:::1132732114437941868

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00152_peaks.txt:::1156309579284390113

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Gentisic acid_C.gif:::1132737701020384365

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00152_peaks.txt:::1156310769090341714

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00152L.png:::117555262510946164; Medium Energy:tbl_ms:::HMDB00152M.png:::117555267868767342; High Energy:tbl_ms:::HMDB00152H.png:::117555271470899837

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Blood

# Concentration_[Normal]:
Not Available


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Asphyxia; Aspirin Overdose; Reye Syndrome

# Pathway_Names:
Valine, leucine and isoleucine degradation;Vitamin B6 metabolism;Nicotinate and nicotinamide metabolism;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
valine,leucine,and_isoleucine_degradation.jpg;;Nicotinamide_synthesis_(NADH).jpg;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00280;map00750;map00760;map00280;map00280

# Pathway_Graphs:
valine,leucine,and_isoleucine_degradation_Graph.jpg;;Nicotinamide_synthesis_(NADH)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
valine,leucine,and_isoleucine_degradation.xml;;Nicotinamide_synthesis_(NADH).xml;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5358

# Metabolic_Enzyme_1_Name:
Aldehyde oxidase

# Metabolic_Enzyme_1_Synonyms:
Not Available

# Metabolic_Enzyme_1_Gene_Name:
AOX1

# Metabolic_Enzyme_1_Protein_Sequence:
>Aldehyde oxidase
MDRASELLFYVNGRKVIEKNVDPETMLLPYLRKKLRLTGTPYGCGGGGCGACTVMISRYN
PITKRIRHHPANACLIPICSLYGAAVTTVEGIGSTHTRIHPVQERIAKCHGTQCGFCTPG
MVMSIYPLLRNHPEPTLDQLTDALGGNLCRCHGYRPIIDACKTFCKTSGCCQSKENGVCC
LDQGINGLPEFEEGSKTSPKLFAEEEFLPLDPTQELIFPPELMIMADKQSQRTRVFGSER
MMWFSPVTLKDLLEFKFKYPQAPVIMGNTSVGPEVKFKGVFHPGYNSPDRIEEPECCKPC
IYGLTLGAGLSLAQVKDILADVVQKLPEEKTQMYHALLKHLGTLAGSQIRNMASLGGHII
SRHPDSDLNPILAVGNCTLNLLSKEGKRQIPLNEQFLSKCPNADLKPQEILVSVNIPISR
KWEFVSAFRQAQRQENALAIVNSGMRVFFGEGDGIIRELCISYGGVGPATICAKNSCQKL
IGRHWNEQMLDIACRLILNEVSLLGSAPGGKVEFKRTLIISFLFKFYLEVSQILKKMDPV
HYPSLADKYESALEDLHSKHHCSTLKYQNIGPKQHPEDPIGHPIMHLSGVKHATGEAIYC
DDMPLVDQELFLTFVTSSRAHAKIVSIDLSEALSMPGVVDIMTAEHLSDVNSFCFFTEAE
KFLATDKVFCVGQLVCAVLADSEVQAKRAAKRVKIVYQDLEPLILTIEESIQHNSSFKPE
RKLEYGNVDEAFKVVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDQEMDVYVSTQFPKY
IQDIVASTLKLPANKVMCHVRRVGGAFGGKVLKTGIIAAVTAFAANKHGRAVRCVLERGE
DMLITGGRHPYLGKYKAGFMNDGRILALDMEHYSNAGASLDESLFVIEMGLLKMDNAYKF
PNLRCRGWACRTNLPSNTAFRGFGFPQAVLITESCITEVAAKCGLSPEKVRIINMYKEID
QTPYKQEINAKNLIQCWRECMAMSSYSLRKVAVEKFNAENYWKKKGLAMVPLKFPVGLAS
RAAGQAAALVHIYLDGSVLVTHGGIEMGQGVHTKMIQVVSRELRMPMSNVHLRGTSTETV
PNANISGGSVVADLNGLAVKDACQTLLKRLEPIISKNPKGTWKDWAQTAFDESINLSAVG
YFRGYESDMNWEKGEGQPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGCSINPAID
IGQIEGAFIQGMGLYTIEELNYSPQGILHTRGPDQYKIPAICDMPTELHIALLPPSQNSN
TLYSSKGLGESGVFLGCSVFFAIHDAVSAARQERGLHGPLTLNSPLTPEKIRMACEDKFT
KMIPRDEPGSYVPWNVPI

# Metabolic_Enzyme_1_Number_of_Residues:
1338

# Metabolic_Enzyme_1_Molecular_Weight:
147933

# Metabolic_Enzyme_1_Theoretical_pI:
7.11

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  transporter activity
Function:  electron transporter activity
Function:  binding
Function:  ion binding
Function:  metal ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
An aldehyde + H(2)O + O(2) = a carboxylic acid + H(2)O(2)

# Metabolic_Enzyme_1_Pathway:
map00280  Valine, leucine and isoleucine degradation;
 map00350  Tyrosine metabolism;
 map00380  Tryptophan metabolism;
 map00750  Vitamin B6 metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_1_Reaction:
an aldehyde + H2O + O2 = a carboxylic acid + H2O2

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01315:Ald_Xan_dh_C;
PF02738:Ald_Xan_dh_C2;
PF03450:CO_deh_flav_C;
PF00941:FAD_binding_5;
PF00111:Fer2;
PF01799:Fer2_2

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.2.3.1

# Metabolic_Enzyme_1_GenBank_ID_Protein:
438656

# Metabolic_Enzyme_1_SwissProt_ID:
ADO_HUMAN (Q06278)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
AOX1

# Metabolic_Enzyme_1_Geneatlas_id:
AOX1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:553

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>4017 bp
ATGGACCGGGCGTCCGAGCTGCTCTTCTACGTGAACGGCCGCAAGGTGATAGAAAAAAAT
GTCGATCCTGAAACAATGCTGTTGCCTTATTTGAGGAAGAAGCTTCGACTCACAGGAACT
CCGTATGGCTGTGGAGGAGGAGGCTGTGGTGCTTGTACAGTGATGATATCACGATACAAC
CCCATCACCAAGAGGATAAGGCATCACCCAGCCAATGCCTGTCTGATTCCCATCTGTTCT
CTGTATGGTGCTGCCGTCACCACAGTAGAAGGCATAGGAAGCACCCACACCAGAATTCAT
CCTGTTCAGGAGAGGATTGCCAAGTGTCATGGCACCCAGTGTGGCTTCTGCACACCTGGG
ATGGTGATGTCCATCTACCCCCTGCTCAGGAACCACCCAGAGCCCACTCTGGATCAGTTA
ACTGATGCCCTTGGTGGTAACCTGTGCCGTTGCCATGGATACAGGCCCATAATTGATGCA
TGCAAGACTTTCTGTAAAACTTCGGGCTGCTGTCAAAGTAAAGAAAATGGGGTTTGCTGT
TTGGATCAAGGAATCAATGGATTGCCAGAATTTGAGGAAGGAAGTAAGACAAGTCCAAAA
CTCTTCGCAGAAGAGGAGTTTCTGCCATTGGATCCAACCCAGGAACTGATATTTCCTCCT
GAGCTAATGATAATGGCTGATAAACAGTCGCAAAGGACCAGGGTGTTTGGCAGTGAGAGA
ATGATGTGGTTTTCCCCCGTGACCCTGAAGGACCTGCTGGAATTTAAATTCAAGTATCCC
CAGGCTCCTGTTATCATGGGAAACACCTCTGTGGGGCCTGAAGTGAAATTTAAAGGCGTC
TTTCACCCAGGTTATAATTCTCCTGATAGAATTGAAGAACCTGAGTGTTGTAAACCATGC
ATATATGGACTCACCCTTGGTGCTGGTCTCAGCCTAGCCCAGGTGAAGGACATTTTGGCT
GATGTAGTCCAGAAGCTTCCAGAGGAGAAGACACAGATGTACCATGCTCTCCTGAAGCAT
TTGGGAACTCTGGCTGGGTCCCAGATCAGGAACATGGCTTCTTTAGGGGGACACATCATT
AGCAGGCATCCAGATTCAGATCTGAATCCCATCCTGGCTGTGGGTAACTGTACCCTCAAC
TTGCTATCAAAAGAAGGAAAACGACAGATTCCTTTAAATGAGCAATTCCTCAGCAAGTGC
CCTAATGCAGATCTTAAGCCTCAAGAAATCTTGGTCTCAGTGAACATCCCCATCTCAAGG
AAGTGGGAATTTGTGTCAGCCTTCCGACAAGCCCAGCGACAGGAGAATGCGCTAGCGATA
GTCAATTCAGGAATGAGAGTCTTTTTTGGAGAAGGGGATGGCATTATTAGAGAGTTATGC
ATCTCATATGGAGGCGTTGGTCCAGCCACCATCTGTGCCAAGAATTCCTGCCAGAAACTC
ATTGGAAGGCACTGGAACGAACAGATGCTGGATATAGCCTGCAGGCTTATTCTGAATGAA
GTCTCCCTTTTGGGCTCGGCGCCAGGTGGGAAAGTGGAGTTCAAGAGGACTCTCATCATC
AGCTTCCTCTTCAAGTTCTACCTGGAAGTGTCACAGATTTTGAAAAAGATGGATCCAGTT
CACTATCCTAGCCTTGCAGACAAGTATGAAAGTGCTTTAGAAGATCTTCATTCCAAACAT
CACTGCAGTACATTAAAGTACCAGAATATAGGCCCAAAGCAGCATCCTGAAGACCCAATT
GGCCACCCCATCATGCATCTGTCTGGTGTGAAGCATGCCACGGGGGAGGCCATCTACTGT
GATGACATGCCTCTGGTGGACCAGGAACTTTTCTTGACTTTTGTGACTAGTTCAAGAGCT
CATGCTAAGATTGTGTCTATTGATCTGTCAGAAGCTCTCAGCATGCCCGGTGTGGTGGAC
ATCATGACAGCAGAACATCTTAGTGACGTCAACTCCTTCTGCTTTTTTACTGAAGCTGAG
AAATTTCTGGCGACAGATAAGGTGTTCTGTGTGGGTCAGCTTGTCTGTGCTGTGCTTGCC
GATTCTGAGGTTCAGGCAAAGCGAGCTGCTAAGCGAGTGAAGATTGTCTATCAAGACTTG
GAGCCGCTGATACTAACAATTGAGGAAAGTATACAACACAACTCCTCCTTCAAGCCAGAA
AGGAAACTGGAATATGGAAATGTTGACGAAGCATTTAAAGTGGTTGATCAAATTCTTGAA
GGTGAAATACATATGGGAGGTCAAGAACATTTTTATATGGAAACCCAAAGCATGCTTGTC
GTTCCCAAGGGAGAGGATCAAGAAATGGATGTCTACGTGTCCACACAGTTTCCCAAATAT
ATACAGGACATTGTTGCCTCAACCTTGAAGCTCCCAGCTAACAAGGTCATGTGCCATGTA
AGGCGTGTTGGTGGAGCGTTTGGAGGGAAGGTGTTAAAAACCGGAATCATTGCAGCCGTC
ACTGCATTTGCCGCAAACAAACATGGCCGTGCAGTTCGCTGTGTTCTGGAACGAGGAGAA
GACATGTTAATAACTGGAGGCCGCCATCCTTACCTTGGAAAGTACAAAGCTGGATTCATG
AACGATGGCAGAATCTTGGCCCTGGACATGGAGCATTACAGCAATGCAGGCGCCTCCTTG
GATGAATCATTATTCGTGATAGAAATGGGACTTCTGAAAATGGACAATGCTTACAAGTTT
CCCAATCTCCGCTGCCGGGGTTGGGCATGCAGAACCAACCTTCCATCCAACACAGCTTTT
CGTGGGTTTGGCTTTCCTCAGGCAGTGCTGATCACCGAATCTTGTATCACGGAAGTTGCA
GCCAAATGTGGACTATCCCCTGAGAAGGTGCGAATCATAAACATGTACAAGGAAATTGAT
CAAACACCCTACAAACAAGAGATCAATGCCAAGAACCTAATCCAGTGTTGGAGAGAATGT
ATGGCCATGTCTTCCTACTCCTTGAGGAAAGTTGCTGTGGAAAAGTTCAATGCAGAGAAT
TATTGGAAGAAGAAAGGACTGGCCATGGTCCCCCTGAAGTTTCCTGTTGGCCTTGCGTCA
CGTGCTGCTGGTCAGGCTGCTGCCTTGGTTCACATTTATCTTGATGGCTCTGTGCTGGTC
ACTCACGGTGGAATTGAAATGGGGCAGGGGGTCCACACTAAAATGATTCAGGTGGTCAGC
CGTGAATTAAGAATGCCAATGTCGAATGTCCACCTGCGTGGAACAAGCACAGAAACTGTC
CCTAATGCAAATATCTCTGGAGGTTCTGTGGTGGCAGATCTCAACGGTTTGGCAGTAAAG
GATGCCTGTCAAACTCTTCTAAAACGCCTCGAACCCATCATCAGCAAGAATCCTAAAGGA
ACTTGGAAAGACTGGGCACAGACTGCTTTTGATGAAAGCATTAACCTTTCAGCTGTTGGA
TACTTCAGAGGTTATGAGTCAGACATGAACTGGGAGAAAGGCGAAGGCCAGCCCTTCGAA
TACTTTGTTTATGGAGCTGCCTGTTCCGAGGTTGAAATAGACTGCCTGACGGGGGATCAT
AAGAACATCAGAACAGACATTGTCATGGATGTTGGCTGCAGTATAAATCCAGCCATTGAC
ATAGGCCAGATTGAAGGTGCATTTATTCAAGGCATGGGACTTTATACAATAGAGGAACTG
AATTATTCTCCCCAGGGCATTCTGCACACTCGTGGTCCAGACCAATATAAAATCCCTGCC
ATCTGTGACATGCCCACGGAGTTGCACATTGCTTTGTTGCCTCCTTCTCAAAACTCAAAT
ACTCTTTATTCATCTAAGGGTCTGGGAGAGTCGGGGGTGTTCCTGGGGTGTTCCGTGTTT
TTCGCTATCCATGACGCAGTGAGTGCAGCACGACAGGAGAGAGGCCTGCATGGACCCTTG
ACCCTTAATAGTCCACTGACCCCGGAGAAGATTAGGATGGCCTGTGAAGACAAGTTCACA
AAAATGATTCCGAGAGATGAACCTGGATCCTACGTTCCTTGGAATGTACCCATCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
L11005

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_1_Locus:
2q33

# Metabolic_Enzyme_1_SNPs:
rs41309768; rs3731722; rs2540065; rs1050887; rs1050884; rs2465665; rs2470900; rs2002957; rs1405984; rs2348021; rs2463492; rs2287013; rs868810; rs2465663; rs1527948; rs1527944; rs2463488; rs2348023; rs2470899; rs2465657; rs2254576; rs1527947; rs2348020; rs6753383; rs6745304; rs3769832; rs1918720; rs6753463; rs1986415; rs2293529; rs2470897; rs2293526; rs6712290; rs1527945; rs4428003; rs4619591; rs9288313; rs4496322; rs2540069; rs3795968; rs6725945; rs2470902; rs6720189; rs7560168; rs2293527; rs7597590; rs2248130; rs4672865; rs10497866; rs13400369; rs2293524; rs2287012; rs3815502; rs3815503; rs2256977; rs4672866; rs2715905; rs7597713; rs12478624; rs4614918; rs2293525; rs2465661; rs7563522; rs2293528; rs7572503; rs7587871; rs4674311; rs7585422; rs10187029; rs6742109; rs12693921; rs2241080; rs13419464; rs4672863; rs16833921; rs17448359; rs6737912; rs2465662; rs2241079; rs6760616; rs4674247; rs7563294; rs10172572; rs7420798; rs4672858; rs12997909; rs6761840; rs4470327; rs11677071; rs1405985; rs6435060; rs6730068; rs3769833; rs17593811; rs6761375; rs2463489; rs1986414; rs2881811; rs17532777; rs2347864; rs17533238; rs2244004; rs11694112; rs4035120; rs10469649; rs17532875; rs10432435; rs2287008; rs2348024; rs11689822; rs11886414; rs12617551; rs6730363; rs16833889; rs10497853; rs17532973; rs7586707; rs2540067; rs1405986; rs12618843; rs2465664; rs12472360; rs4541241; rs2348025; rs17532798; rs17448345; rs10497865; rs13404701; rs11887334; rs13023526; rs12993621; rs2287010; rs3769835; rs12472146; rs13383127; rs2715904; rs2348026; rs10183589; rs12612264; rs4672890; rs2960198; rs17533140; rs6732225; rs4456685; rs2347866; rs12478294; rs10180210; rs10469650; rs10469754; rs7426150; rs11897036; rs17532861; rs10179330; rs16833885; rs17533070; rs6711025; rs6761252; rs10931910; rs10204846; rs2540068; rs10931908; rs1527946; rs2247553; rs10206891; rs17533245; rs17448443; rs13419468; rs4674302; rs4503970; rs2715910; rs2465658; rs6754573; rs4508579; rs17448796; rs12620550; rs17448686; rs12620549; rs4674211; rs12620402; rs2715908; rs2287011; rs1986390; rs2287007; rs7562507; rs3769834; rs6735253; rs17636860; rs10207809; rs16833843; rs7595235; rs17448457; rs13406379; rs2960199; rs4674303; rs7569193; rs2463490; rs12612263; rs10183184; rs6724797; rs2715907; rs10179964; rs7598198; rs4337457; rs2516310; rs2347865; rs3820973; rs10210831; rs2540066; rs17448366; rs2072034; rs12621063; rs2715906; rs16833793; rs35345784; rs35217482; rs35128788; rs34799295; rs13023698; rs35999824; rs13408225; rs16833923; rs1050883; rs34427902; rs1131360; rs1050880; rs35293679; rs34110600; rs2241078; rs2348022; rs36084232; rs34698837; rs34892292; rs2463491; rs2470898; rs35076002; rs34217541; rs41270243; rs2715912; rs4674312; rs34095667; rs13402885; rs34380410; rs17594160; rs34436757; rs35754442; rs35527063; rs11901126; rs10460401; rs2465656; rs10192757; rs2287009; rs10179743; rs34769434; rs34936215; rs11420110; rs35886858; rs4384770; rs35423095; rs34397235; rs35057419; rs6741421; rs35569511; rs34169163; rs35035526; rs34423504; rs36054632; rs17533098; rs12466511; rs34606301; rs12464348; rs2470901; rs4350730; rs16833848; rs34138997; rs34016786; rs13008443; rs34185958; rs6435057; rs4672864; rs34356762; rs17448436; rs34831618; rs35918797; rs13391622; rs35794546; rs6147125; rs13034124; rs35778058; rs2960200; rs10192320; rs13423540; rs6728850; rs12993144; rs6728655; rs3769831; rs10931909; rs35245400; rs34772975; rs12988162; rs10623702; rs35236730; rs11373771; rs34817848; rs35482569; rs13035983; rs34032166; rs35483227; rs35482626; rs10191685; rs4035251; rs5018931; rs34962228; rs35020940; rs35045512; rs13019825; rs34887452; rs13393615; rs41271445; rs35698374; rs4622702; rs35086177; rs11676316; rs34332493; rs35539595; rs4674202; rs6147126; rs9808414; rs10203810; rs10192066; rs2465659; rs11455886; rs34798357; rs11397147; rs4261701; rs34408231; rs34266344; rs35993423; rs34473107; rs34930734; rs3038607; rs34303220; rs13432214; rs13432700; rs34560359; rs1989739; rs2715911; rs41270241; rs35309776; rs35763564; rs35987427; rs11684094; rs13385678; rs34620856; rs5837752; rs4621154; rs34299045; rs34602028; rs34451961; rs10664948; rs6750300; rs34882667; rs34272316; rs35908613; rs36046548; rs13398115; rs11680797; rs34570620; rs4674197; rs11370694; rs12621852; rs11677893; rs11678615; rs11684227; rs11691962; rs12622081; rs13026134; rs13027665; rs13419425; rs16834021; rs16834027; rs16834034; rs2540064; rs4132842; rs4132843; rs4674194; rs6729738; rs7563682; rs7594798; rs7607141; rs878403

# Metabolic_Enzyme_1_General_References:
8248161

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6878

# Metabolic_Enzyme_2_Name:
Catalase

# Metabolic_Enzyme_2_Synonyms:
Not Available

# Metabolic_Enzyme_2_Gene_Name:
CAT

# Metabolic_Enzyme_2_Protein_Sequence:
>Catalase
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT
KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD
THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE
HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK
NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL

# Metabolic_Enzyme_2_Number_of_Residues:
527

# Metabolic_Enzyme_2_Molecular_Weight:
59757

# Metabolic_Enzyme_2_Theoretical_pI:
7.41

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  catalase activity
 ||
>>>
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide

# Metabolic_Enzyme_2_Pathway:
map00380  Tryptophan metabolism;
 map00680  Methane metabolism

# Metabolic_Enzyme_2_Reaction:
2 H2O2 = O2 + 2 H2O

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00199:Catalase

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.11.1.6

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1228085

# Metabolic_Enzyme_2_SwissProt_ID:
CATA_HUMAN (P04040)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
CAT

# Metabolic_Enzyme_2_Geneatlas_id:
CAT

# Metabolic_Enzyme_2_hgnc_id:
HGNC:1516

# Metabolic_Enzyme_2_PDB_ID:
1F4J

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_2_Gene_Sequence:
>66 bp
ATGGCTGACAGCCGGGATCCCGCCAGCGACCAGATGCAGCACTGGAAGGAGCAGCGGGCC
GCGCAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X04085

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_2_Locus:
11p13

# Metabolic_Enzyme_2_SNPs:
rs17880442; rs11032709; rs769217; rs35677492; rs1049982; rs2234940; rs1050032; rs566979; rs769218; rs511895; rs524167; rs494024; rs1408035; rs560807; rs10488736; rs2284367; rs482322; rs7947841; rs480496; rs11032699; rs2300182; rs2284365; rs7103083; rs499406; rs3758730; rs4755372; rs508370; rs7933285; rs1000343; rs554576; rs2073059; rs11032701; rs17886008; rs4755373; rs484214; rs6484722; rs543701; rs17884666; rs2420389; rs551929; rs480575; rs10836244; rs2179625; rs7113917; rs2268063; rs533425; rs12272630; rs17881488; rs486256; rs17884576; rs2073058; rs11604331; rs17884491; rs7120960; rs1408034; rs524154; rs7109778; rs7101395; rs17881288; rs12269988; rs7126610; rs10836235; rs16925608; rs16925614; rs11824384; rs2284368; rs17883121; rs2420388; rs4756146; rs16925606; rs17884086; rs2284364; rs7930427; rs12803540; rs1408036; rs17268652; rs2284366; rs17881567; rs2300181; rs7928213; rs11032702; rs16925581; rs525938; rs11032700; rs17881921; rs17884095; rs17885743; rs17881476; rs17883793; rs11826620; rs12270780; rs35915891; rs2268064; rs17883592; rs17884725; rs17881482; rs17880673; rs2284369; rs17883544; rs11032703; rs12273124; rs17884248; rs35755143; rs7126640; rs2076556; rs4755374; rs1055981; rs17884335; rs17884518; rs17880274; rs17883699; rs4756148; rs17886200; rs475043; rs564250; rs769214; rs9282626; rs7943316; rs9282627; rs7104301; rs17883920; rs1001179; rs17881029; rs17886350; rs2266625; rs34455645; rs3180560; rs11546300; rs1050028; rs2266629; rs2266619; rs14527; rs2266628; rs35012776; rs34964953; rs34727149; rs3831770; rs17886810; rs35927227; rs7121850; rs17885881; rs17882812; rs17885837; rs17880607; rs17882039; rs17881916; rs17880549; rs34138762; rs28586982; rs34503767; rs36074933; rs515130; rs35099202; rs35849009; rs17881846; rs17887048; rs17881224; rs17884421; rs34840731; rs17881231; rs35340649; rs35292563; rs17884242; rs12286702; rs35034960; rs28733253; rs17887248; rs35791482; rs35703808; rs35648206; rs34808995; rs35386961; rs34420404; rs856714; rs17883483; rs17884804; rs17883367; rs17883534; rs17880160; rs17886672; rs34281397; rs34790990; rs2982523; rs35122257; rs2284370; rs12798927; rs35781217; rs11032707; rs17886592; rs4483566; rs34890123; rs4272763; rs12789374; rs17881734; rs35330036; rs17883434; rs35081167; rs17886155; rs17886248; rs34840787; rs34890990; rs17881192; rs17881586; rs34267165; rs12786539; rs35834969; rs3818354; rs17884443; rs36224415; rs36224416; rs36224102; rs10312; rs10836230; rs10836233; rs10836234; rs11032717; rs1107573; rs11606946; rs12284341; rs12807961; rs12808450; rs1323690; rs1535718; rs1535719; rs1535720; rs1535721; rs16925525; rs2073057; rs208678; rs208679; rs208681; rs208682; rs208683; rs2231828; rs2266624; rs2266630; rs2296144; rs409598; rs554518; rs7109862; rs7114869; rs7118388; rs7928156; rs7941147; rs7944397; rs7949972

# Metabolic_Enzyme_2_General_References:
3755525; 3755526; 11728823; 8282800; 12665801; 6548744; 10666617; 10656833; 11134921

# Metabolic_Enzyme_2_References:
12688421; 2557038

End of HMDB00152

Beginning of HMDB00153
# Accession_No:
HMDB00153

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2006-08-17 14:49:59

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Estriol

# Description:
A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol. -- Pubchem; Estriol (also oestriol) is one of the three main estrogens produced by the human body. It is only produced in significant amounts during pregnancy as it is made by the fetus. -- Wikipedia

# Synonyms:
13b-Methyl-1,3,5(10)-gonatriene-3,16a,17b-triol; 16-alpha,17-beta-Estriol; 16-alpha,17-beta-Oestriol; 16-alpha-Hydroxyestradiol; 16-alpha-Hydroxyoestradiol; 16a,17b-Estriol; 16a-Estriol; 16a-Hydroxyestradiol; 16alpha,17beta-Estriol; 16alpha,17beta-Oestriol; 16alpha-Hydroxy-17beta-estradiol; 16alpha-Hydroxyestradiol; 16alpha-Hydroxyoestradiol; 3,16a,17b-Estriol; 3,16a,17b-Trihydroxyestra-1,3,5(10)-triene; 3,16alpha,17beta-Trihydroxy-1,3,5(10)-estratriene; 3,16alpha,17beta-Trihydroxyestra-1,3,5(10)-triene; Aacifemine; Colpogyn; Colpovister; Destriol; Deuslon A; Deuslon-A; Estra-1,3,5(10)-triene-3,16a,17b-triol; Estratriol; Estriel; Estriol; Follicular hormone hydrate; Gynasan; Hemostyptanon; Holin V; Hormomed; Incurin; Klimax E; Klimoral; Oekolp; Oestratriol; Oestriol; Oestriolum; Orestin; Orgastyptin; Ortho-Gynest; Ovesterin; Ovestin; Ovestinon; Ovestrion; Ovo-Vinces; Theelol; Tridestrin; Trihydroxyestrin; Triovex

# Chemical_IUPAC_Name:
(8S,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol

# Chemical_Formula:
C18H24O3

# Chemical_Structure:
tbl_chemical:::HMDB00153_ZOOM.png:::119283221943081892

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00153_THUMB.png:::119283221743685652

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Steroids; Sterols

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
secondary alcohol; 1,2-diol; phenol or hydroxyhetarene; aromatic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
288.17255

# Molecular_Weight_Avg:
288.38135

# Smiles_String_isomeric:
C[C@]12CC[C@H]3[C@@H](CCC4=C3C=CC(O)=C4)[C@@H]1C[C@@H](O)[C@@H]2O

# Smiles_String_canonical:
CC12CCC3C(CCC4=C3C=CC(O)=C4)C1CC(O)C2O

# KEGG_Compound_ID:
C05141

# BioCyc_ID:
Not Available

# PubChem_CID:
5756

# PubChem_SID:
7887358; 7854791; 8153533; 11533161; 8137982; 7560; 7847253; 148535; 76927; 11467124; 584764; 841394; 11468244; 7979190; 11486792; 11532998

# OMIM_ID:
122560; 201400; 218030; 270400; 308100

# Metagene_ID:
Not Available

# BiGG_ID:
45207

# Wikipedia_ID:
Estriol

# METLIN_ID:
2581

# Ref_ID:
6374294; 12424769; 2621854; 3583036; 752645; 2994907; 7139918; 8469492; 1718632; 6640903; 6690116; 3629582; 10083784; 1171044; 16009196

# ChEBI_ID:
27974

# CAS_Registry_Number:
50-27-1

# InChI:
InChI=1/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1

# Synthesis_Reference:
Not Available

# Melting_Point:
282 oC

# Melting_Point_predicted:
130.2 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
0.441 mg/mL [MEYLAN,WM et al. (1996)]; 0.119 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
2.45 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
2.54 [Predicted by ALOGPS]; 3.6 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Estriol.pdf:::1132562207279457456

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Estriol.mol:::1132723810406862579

# SDF_File_[Text]:
tbl_chemical:::HMDB00153.sdf:::119283221213250346

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00153.pdb:::119283221605832600

# PDB_ID:
1X8V

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Estriol.gif:::1132732114640293696

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00153_peaks.txt:::1156309580316674634

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Estriol_C.gif:::113273770165113444

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00153_peaks.txt:::1156310770114979862

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00153L.png:::117555263036943157; Medium Energy:tbl_ms:::HMDB00153M.png:::117555268418670506; High Energy:tbl_ms:::HMDB00153H.png:::117555271704448276

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane (Predicted from LogP); Cytoplasm; endoplasmic reticulum

# Tissue_Location:
Adrenal Cortex; Adrenal Gland; Placenta; Placental; Testes

# deuterated:
No

# Biofluid_Location:
Not Available

# Concentration_[Normal]:
Not Available


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Down's Syndrome; Steroid Sulfatase Deficiency; Trisomy 18

# Pathway_Names:
Pentose and glucuronate interconversions;Androgen and estrogen metabolism;Starch and sucrose metabolism;Porphyrin and chlorophyll metabolism;Fatty acid biosynthesis (path 2);Fatty acid metabolism;Valine, leucine and isoleucine degradation;Lysine degradation;Benzoate degradation via CoA ligation;Butanoate metabolism;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
;;;;;;valine,leucine,and_isoleucine_degradation.jpg;Lysine_degradation.jpg;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00040;map00150;map00500;map00860;map00062;map00071;map00280;map00310;map00632;map00650;map00280;map00280

# Pathway_Graphs:
;;;;;;valine,leucine,and_isoleucine_degradation_Graph.jpg;Lysine_degradation_Graph.jpg;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
;;;;;;valine,leucine,and_isoleucine_degradation.xml;Lysine_degradation.xml;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5731

# Metabolic_Enzyme_1_Name:
UDP-glucuronosyltransferase 2B17 precursor

# Metabolic_Enzyme_1_Synonyms:
UDPGT; C19- steroid-specific UDP-glucuronosyltransferase

# Metabolic_Enzyme_1_Gene_Name:
UGT2B17

# Metabolic_Enzyme_1_Protein_Sequence:
>UDPglucuronosyltransferase 2B17 precursor
MSLKWMSVFLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSA
SILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEY
SDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYT
VEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEV
LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
MSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVA
AHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLFCFRKLAKTGKKKKRD

# Metabolic_Enzyme_1_Number_of_Residues:
530

# Metabolic_Enzyme_1_Molecular_Weight:
61096

# Metabolic_Enzyme_1_Theoretical_pI:
8.73

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3alpha,17beta-diol (3alpha-diol) > testosterone > androsterone (ADT)

# Metabolic_Enzyme_1_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_1_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_1_Signals:
1-23

# Metabolic_Enzyme_1_Transmembrane_Regions:
495-515

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_1_GenBank_ID_Protein:
3287473

# Metabolic_Enzyme_1_SwissProt_ID:
UDB17_HUMAN (O75795)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
UGT2B17

# Metabolic_Enzyme_1_Geneatlas_id:
UGT2B17

# Metabolic_Enzyme_1_hgnc_id:
HGNC:12547

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Microsome

# Metabolic_Enzyme_1_Gene_Sequence:
>1593 bp
ATGTCTCTGAAATGGATGTCAGTCTTTCTGCTGATGCAGCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATACAGCCATTGGATAAATATGAAG
ACAATCCTGGAAGAGCTTGTTCAGAGGGGTCATGAGGTGATTGTGTTGACATCTTCGGCT
TCTATTCTTGTCAATGCCAGTAAATCATCTGCTATTAAATTAGAAGTTTATCCTACATCT
TTAACTAAAAATGATTTGGAAGATTTTTTTATGAAAATGTTCGATAGATGGACATATAGT
ATTTCAAAAAATACATTTTGGTCATATTTTTCACAACTACAAGAATTGTGTTGGGAATAT
TCTGACTATAATATAAAGCTCTGTGAAGATGCAGTTTTGAACAAGAAACTTATGAGAAAA
CTACAAGAGTCAAAATTTGATGTCCTTCTGGCAGATGCCGTTAATCCCTGTGGTGAGCTG
CTGGCTGAACTACTTAACATACCCTTTCTGTACAGTCTCCGCTTCTCTGTTGGCTACACA
GTTGAGAAGAATGGTGGAGGATTTCTGTTCCCTCCTTCCTATGTACCTGTTGTTATGTCA
GAATTAAGTGATCAAATGATTTTCATGGAGAGGATAAAAAATATGATATATATGCTTTAT
TTTGACTTTTGGTTTCAAGCATATGATCTGAAGAAGTGGGACCAGTTTTATAGTGAAGTT
CTAGGAAGACCCACTACATTATTTGAGACAATGGGGAAAGCTGAAATGTGGCTCATTCGA
ACCTATTGGGATTTTGAATTTCCTCGCCCATTCTTACCAAATGTTGATTTTGTTGGAGGA
CTTCACTGTAAACCAGCCAAACCCTTGCCTAAGGAAATGGAAGAGTTTGTGCAGAGCTCT
GGAGAAAATGGTATTGTGGTGTTTTCTCTGGGGTCGATGATCAGTAACATGTCAGAAGAA
AGTGCCAACATGATTGCATCAGCCCTTGCCCAGATCCCACAAAAGGTTCTATGGAGATTT
GATGGCAAGAAGCCAAATACTTTAGGTTCCAATACTCGACTGTATAAGTGGTTACCCCAG
AATGACCTTCTTGGTCATCCCAAAACCAAAGCTTTTATAACTCATGGTGGAACCAATGGC
ATCTATGAGGCGATCTACCATGGGATCCCTATGGTGGGCATTCCCTTGTTTGCGGATCAA
CATGATAACATTGCTCACATGAAAGCCAAGGGAGCAGCCCTCAGTGTGGACATCAGGACC
ATGTCAAGTAGAGATTTGCTCAATGCATTGAAGTCAGTCATTAATGACCCTATCTATAAA
GAGAATATCATGAAATTATCAAGAATTCATCATGATCAACCGGTGAAGCCCCTGGATCGA
GCAGTCTTCTGGATTGAGTTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTCGCA
GCCCACAACCTCACCTGGATCCAGTACCACTCTTTGGATGTGATAGCATTCCTGCTGGCC
TGCGTGGCAACTATGATATTTATGATCACAAAATGTTGCCTGTTTTGTTTCCGAAAGCTT
GCCAAAACAGGAAAGAAGAAGAAAAGGGATTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U59209

# Metabolic_Enzyme_1_Chromosome_Location:
Not Available

# Metabolic_Enzyme_1_Locus:
Not Available

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
8798464; 9364925

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5716

# Metabolic_Enzyme_2_Name:
Peroxisomal multifunctional enzyme type 2

# Metabolic_Enzyme_2_Synonyms:
MFE-2; D-bifunctional protein; DBP; 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-3-hydroxyacyl-CoA dehydratase; 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; 3- hydroxyacyl-CoA dehydrogenase

# Metabolic_Enzyme_2_Gene_Name:
HSD17B4

# Metabolic_Enzyme_2_Protein_Sequence:
>Peroxisomal multifunctional enzyme type 2
MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVE
EIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIH
RVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAI
EGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVG
AGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLS
KIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKD
LKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRA
GKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKV
AVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFS
ARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISN
AYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNI
GAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNI
MLSQKLQMILKDYAKL

# Metabolic_Enzyme_2_Number_of_Residues:
736

# Metabolic_Enzyme_2_Molecular_Weight:
79687

# Metabolic_Enzyme_2_Theoretical_pI:
9.21

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  steroid binding
Function:  sterol carrier activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids

# Metabolic_Enzyme_2_Pathway:
map00062  Fatty acid biosynthesis (path 2);
 map00071  Fatty acid metabolism;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00380  Tryptophan metabolism;
 map00632  Benzoate degradation via CoA ligation;
 map00650  Butanoate metabolism;
 map00930  Caprolactam degradation

# Metabolic_Enzyme_2_Reaction:
(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00106:adh_short;
PF01575:MaoC_dehydratas;
PF02036:SCP2

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 4.2.1.107;EC 1.1.1.35

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1050517

# Metabolic_Enzyme_2_SwissProt_ID:
DHB4_HUMAN (P51659)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
HSD17B4

# Metabolic_Enzyme_2_Geneatlas_id:
HSD17B4

# Metabolic_Enzyme_2_hgnc_id:
HGNC:5213

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_2_Gene_Sequence:
>2211 bp
ATGGGCTCACCGCTGAGGTTCGACGGGCGGGTGGTACTGGTCACCGGCGCGGGGGCAGGA
TTGGGCCGAGCCTATGCCCTGGCTTTTGCAGAAAGAGGAGCGTTAGTTGTTGTGAATGAT
TTGGGAGGGGACTTCAAAGGAGTTGGTAAAGGCTCCTTAGCTGCTGATAAGGTTGTTGAA
GAAATAAGAAGGAGAGGTGGAAAAGCAGTGGCCAACTATGATTCAGTGGAAGAAGGAGAG
AAGGTTGTGAAGACAGCCCTGGATGCTTTTGGAAGAATAGATGTTGTGGTCAACAATGCT
GGAATTCTGAGGGATCGTTCCTTTGCTAGGATAAGTGATGAAGACTGGGATATAATCCAC
AGAGTTCATTTGCGGGGTTCATTCCAAGTGACACGGGCAGCATGGGAACACATGAAGAAA
CAGAAGTATGGAAGGATTATTATGACTTCATCAGCTTCAGGAATATATGGCAACTTTGGC
CAGGCCAATTATAGTGCTGCAAAGTTGGGTCTTCTGGGCCTTGCAAATTCTCTTGCAATT
GAAGGCAGGAAAAGCAACATTCATTGTAACACCATTGCTCCTAATGCGGGATCACGGATG
ACTCAGACAGTTATGCCTGAAGATCTTGTGGAAGCCCTGAAGCCAGAGTATGTGGCACCT
CTTGTCCTTTGGCTTTGTCACGAGAGTTGTGAGGAGAATGGTGGCTTGTTTGAGGTTGGA
GCAGGATGGATTGGAAAATTACGCTGGGAGCGGACTCTTGGAGCTATTGTAAGACAAAAG
AATCACCCAATGACTCCTGAGGCAGTCAAGGCTAACTGGAAGAAGATCTGTGACTTTGAG
AATGCCAGCAAGCCTCAGAGTATCCAAGAATCAACTGGCAGTATAATTGAAGTTCTGAGT
AAAATAGATTCAGAAGGAGGAGTTTCAGCAAATCATACTAGTCGTGCAACGTCTACAGCA
ACATCAGGATTTGCTGGAGCTATTGGCCAGAAACTCCCTCCATTTTCTTATGCTTATACG
GAACTGGAAGCTATTATGTATGCCCTTGGAGTGGGAGCGTCAATCAAGGATCCAAAAGAT
TTGAAATTTATTTATGAAGGAAGTTCTGATTTCTCCTGTTTGCCCACCTTCGGAGTTATC
ATAGGTCAGAAATCTATGATGGGTGGAGGATTAGCAGAAATTCCTGGACTTTCAATCAAC
TTTGCAAAGGTTCTTCATGGAGAGCAGTACTTAGAGTTATATAAACCACTTCCCAGAGCA
GGAAAATTAAAATGTGAAGCAGTTGTTGCTGATGTCCTAGATAAAGGATCCGGTGTAGTG
ATTATTATGGATGTCTATTCTTATTCTGAGAAGGAACTTATATGCCACAATCAGTTCTCT
CTCTTTCTTGTTGGCTCTGGAGGCTTTGGTGGAAAACGGACATCAGACAAAGTCAAGGTA
GCTGTAGCCATACCTAATAGACCTCCTGATGCTGTACTTACAGATACCACCTCTCTTAAT
CAGGCTGCTTTGTACCGCCTCAGTGGAGACTGGAATCCCTTACACATTGATCCTAACTTT
GCTAGTCTAGCAGGTTTTGACAAGCCCATATTACATGGATTATGTACATTTGGATTTTCT
GCCAGGCGTGTGTTACAGCAGTTTGCAGATAATGATGTGTCAAGATTCAAGGCAATTAAG
GCTCGTTTTGCAAAACCAGTATATCCAGGACAAACTCTACAAACTGAGATGTGGAAGGAA
GGAAACAGAATTCATTTTCAAACCAAGGTCCAAGAAACTGGAGACATTGTCATTTCAAAT
GCATATGTGGATCTTGCACCAACATCTGGTACTTCAGCTAAGACACCCTCTGAGGGCGGG
AAGCTTCAGAGTACCTTTGTATTTGAGGAAATAGGACGCCGCCTAAAGGATATTGGGCCT
GAGGTGGTGAAGAAAGTAAATGCTGTATTTGAGTGGCATATAACCAAAGGCGGAAATATT
GGGGCTAAGTGGACTATTGACCTGAAAAGTGGTTCTGGAAAAGTGTACCAAGGCCCTGCA
AAAGGTGCTGCTGATACAACAATCATACTTTCAGATGAAGATTTCATGGAGGTGGTCCTG
GGCAAGCTTGACCCTCAGAAGGCATTCTTTAGTGGCAGGCTGAAGGCCAGAGGGAACATC
ATGCTGAGCCAGAAACTTCAGATGATTCTTAAAGACTACGCCAAGCTCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X87176

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_2_Locus:
5q21

# Metabolic_Enzyme_2_SNPs:
rs25640; rs1143650; rs28943589; rs28943594; rs28943592; rs11539471; rs11205; rs28943591; rs28943590; rs28943588; rs2560722; rs12714; rs28943596; rs28943595; rs35293303; rs34753910; rs34353289; rs34604765; rs35520682; rs35233505; rs34381335; rs32659; rs382719; rs32651; rs2678091; rs26181; rs2451816; rs2678070; rs2459726; rs2636962; rs2546210; rs2636968; rs257970; rs1490756; rs2636961; rs2678074; rs10078097; rs26184; rs32665; rs11241506; rs2636964; rs2945327; rs10036783; rs463513; rs161857; rs422297; rs10064000; rs2259347; rs7714121; rs2287712; rs450118; rs257972; rs457106; rs11241507; rs32662; rs439954; rs7716785; rs2560723; rs455949; rs39970; rs161852; rs11957255; rs7706359; rs3797364; rs2652698; rs257973; rs257976; rs3797360; rs11748530; rs12189265; rs12655113; rs174008; rs32661; rs33950298; rs3756512; rs3850200; rs39971; rs32664; rs11746780; rs28590215; rs11749784; rs11949608; rs460274; rs3797368; rs10478424; rs6895345; rs32666; rs426899; rs17145473; rs2636965; rs3797372; rs257971; rs257969; rs2678077; rs6894991; rs3822527; rs150938; rs3797371; rs10041122; rs257985; rs257978; rs9327101; rs2404780; rs33926345; rs3797367; rs7708761; rs10051019; rs7723390; rs12653056; rs3797363; rs491526; rs9885031; rs2678076; rs17453681; rs6897978; rs11952687; rs2678067; rs12658566; rs17145475; rs17145464; rs10069875; rs17388769; rs2546209; rs28943593; rs11748477; rs442923; rs11744058; rs12653702; rs2257900; rs11949545; rs27938; rs6898518; rs6881294; rs528723; rs35509376; rs10440770; rs3756513; rs3850201; rs34072936; rs1155777; rs11738162; rs2546206; rs2678093; rs257974; rs2257901; rs161856; rs36201182; rs34742029; rs17145476; rs2636966; rs257977; rs10061692; rs2075698; rs10057944; rs13361193; rs381703; rs3756510; rs35201279; rs2678092; rs34843661; rs366568; rs2455463; rs10057263; rs36085051; rs2884597; rs10072256; rs9885037; rs10477586; rs10478426; rs10042168; rs34154113; rs257980; rs3933553; rs10041785; rs34480380; rs2678083; rs34894277; rs2303003; rs34554885; rs10045066; rs2678069; rs17145459; rs10040115; rs32663; rs2678075; rs17145471; rs2459727; rs32650; rs460945; rs13360025; rs2678082; rs34787820; rs36121886; rs17145469; rs35312742; rs11950471; rs34061771; rs3797365; rs2636967; rs34414937; rs32649; rs34019509; rs10062410; rs11742193; rs35442141; rs26183; rs2451814; rs3822525; rs257983; rs10463469; rs3797362; rs35908640; rs10073818; rs10045177; rs161851; rs35164142; rs34769530; rs10064454; rs10059654; rs28943586; rs28943587; rs11739468; rs34915828; rs35929961; rs35255511; rs34277908; rs35695978; rs26180; rs34300615; rs35121430; rs11539469; rs35281104; rs34959311; rs34407657; rs35065909; rs11539472; rs35946650; rs154596; rs35416500; rs2678097; rs35150552; rs28771700; rs35717907; rs34077636; rs10069657; rs28488436; rs9327103; rs35972810; rs11441269; rs35331622; rs35370764; rs35118616; rs11423266; rs35557161; rs7702730; rs34241171; rs35764784; rs34076336; rs161855; rs183761; rs3839244; rs13170615; rs28448457; rs28558429; rs34117860; rs10057643; rs34290512; rs3797369; rs2678073; rs6149207; rs11408993; rs34741016; rs35892291; rs35235684; rs11449982; rs34025534; rs34230952; rs2546202; rs9327102; rs13436061; rs28762138; rs35193622; rs13152959; rs2636972; rs35815725; rs35103609; rs2678096; rs4026601; rs34403323; rs5870858; rs13173615; rs2451815; rs3839245; rs3905777; rs13164650; rs161853; rs35896589; rs34776349; rs2636960; rs2546207; rs4472288; rs34797263; rs28371777; rs13179390; rs12658127; rs35513863; rs32660; rs34379490; rs13436451; rs2678071; rs2884596; rs34840516; rs35002045; rs28863779; rs4895193; rs17453513; rs2678072; rs3044997; rs35932005; rs34387330; rs34583966; rs35182344; rs2678068; rs35548886; rs10066301; rs2546203; rs35441752; rs11429994; rs34254740; rs28792671; rs35783015; rs35423756; rs36201214; rs34680033; rs34085452; rs13172850; rs3912770; rs3902524; rs10524491; rs35988302; rs28673725; rs10478425; rs35917386; rs28504028; rs1298928; rs13436186; rs2636959; rs34853445; rs10053773; rs34532819; rs28588064; rs10601221; rs2560724; rs12518814; rs2678095; rs34752619; rs13165698; rs257984; rs34691264; rs35315796; rs35747045; rs34859617; rs33991989; rs4266437; rs36033978; rs3839246; rs35916235; rs34704044; rs35689326; rs33948978; rs28683657; rs257979; rs11423247; rs28447568; rs36012938; rs10066302; rs34132585; rs2546204; rs13356711; rs10434766; rs11959382; rs3951345; rs11435738; rs3797366; rs35833256; rs2678094; rs11438902; rs35335781; rs2546205; rs34941861; rs11949790; rs4084849; rs3907443; rs28667304; rs35246432; rs161854; rs28501075; rs33962138; rs33937106; rs34359926; rs35819200; rs11308278; rs2546208; rs257975; rs7707838; rs34544399; rs2431545; rs28660051; rs11390174; rs2546211; rs2546212; rs13187421; rs13171550; rs11418368; rs5870857; rs35382678; rs12187149; rs35756585; rs13170866; rs35839873; rs36201183; rs2884522; rs12659452; rs2258658; rs35578461; rs3839243; rs34405263; rs35685451; rs13357948; rs6149208; rs35030315; rs35615592; rs3797361; rs32648; rs34464568; rs17552003; rs34245726; rs34926907; rs34429844; rs34401184; rs34212912; rs34142650; rs35833497; rs35305966; rs34812774; rs35181403; rs35999064; rs34198983; rs10043526; rs11951660; rs11955089; rs11956487; rs11959643; rs11959717; rs13361084; rs1651227; rs1651228; rs17145477; rs2560718; rs2560719; rs2560720; rs2561494; rs2636970; rs32647; rs463098

# Metabolic_Enzyme_2_General_References:
7487879; 9089413; 9880674; 8902629; 11700068

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5741

# Metabolic_Enzyme_3_Name:
UDP-glucuronosyltransferase 1-7 precursor

# Metabolic_Enzyme_3_Synonyms:
UDP- glucuronosyltransferase 1A7; UDPGT; UGT1*7; UGT1-07; UGT1.7; UGT- 1G; UGT1G

# Metabolic_Enzyme_3_Gene_Name:
UGT1A7

# Metabolic_Enzyme_3_Protein_Sequence:
>UDPglucuronosyltransferase 17 precursor
MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLF
FSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEG
AQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_3_Number_of_Residues:
530

# Metabolic_Enzyme_3_Molecular_Weight:
59819

# Metabolic_Enzyme_3_Theoretical_pI:
7.85

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_3_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_3_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_3_Signals:
1-25

# Metabolic_Enzyme_3_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_3_GenBank_ID_Protein:
2039360

# Metabolic_Enzyme_3_SwissProt_ID:
UD17_HUMAN (Q9HAW7)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
UGT1A7

# Metabolic_Enzyme_3_Geneatlas_id:
UGT1A7

# Metabolic_Enzyme_3_hgnc_id:
HGNC:12539

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Microsome

# Metabolic_Enzyme_3_Gene_Sequence:
>1593 bp
ATGGCTCGTGCAGGGTGGACTGGCCTCCTTCCCCTATATGTGTGTCTACTGCTGACCTGT
GGCTTTGCCAAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGCCACTGGTTCACC
ATGCAGTCGGTGGTGGAGAAACTCATCCTCAGGGGGCATGAGGTGGTCGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGGAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCA
TACACTCTGGAGGATCAGGACCGGGAGTTCATGGTTTTTGCCGATGCTCGCTGGACGGCA
CCATTGCGAAGTGCATTTTCTCTATTAACAAGTTCATCCAATGGTATTTTTGACTTATTT
TTTTCAAATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGT
TGTTTTGATGCAGTGTTTCTCGATCCTTTTGATGCCTGTGGCTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCGCCAGGGGAATATTTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGACTTCTCTTAGGGTTCTCAGACGCC
ATGACTTTCAAGGAGAGAGTATGGAACCACATCATGCACTTGGAGGAACATTTATTTTGC
CCCTATTTTTTCAAAAATGTCTTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACTGACTTTGTTTTGGAG
TATCCCAAACCCGTGATGCCCAATATGATCTTCATTGGTGGTATCAACTGTCATCAGGGA
AAGCCAGTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGCTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTTCAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U89507

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_3_Locus:
2q37

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
9271343; 11434514; 11037804

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5727

# Metabolic_Enzyme_4_Name:
UDP-glucuronosyltransferase 1-8 precursor

# Metabolic_Enzyme_4_Synonyms:
UDP- glucuronosyltransferase 1A8; UDPGT; UGT1*8; UGT1-08; UGT1.8; UGT- 1H; UGT1H

# Metabolic_Enzyme_4_Gene_Name:
UGT1A8

# Metabolic_Enzyme_4_Protein_Sequence:
>UDPglucuronosyltransferase 18 precursor
MARTGWTSPIPLCVSLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLGKSLNCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLF
FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDACGLIVAKYFSLPSVVFARGIACHYLEEG
AQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLFCQYFSKNALEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_4_Number_of_Residues:
530

# Metabolic_Enzyme_4_Molecular_Weight:
59742

# Metabolic_Enzyme_4_Theoretical_pI:
7.73

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_4_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_4_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_4_Signals:
1-25

# Metabolic_Enzyme_4_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_4_GenBank_ID_Protein:
2613044

# Metabolic_Enzyme_4_SwissProt_ID:
UD18_HUMAN (Q9HAW9)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
UGT1A8

# Metabolic_Enzyme_4_Geneatlas_id:
UGT1A8

# Metabolic_Enzyme_4_hgnc_id:
HGNC:12540

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Microsome

# Metabolic_Enzyme_4_Gene_Sequence:
>1593 bp
ATGGCTCGCACAGGGTGGACCAGCCCCATTCCCCTATGTGTTTCTCTGCTGCTGACCTGT
GGCTTTGCTGAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGTCACTGGTTCACC
ATGCAGTCGGTGGTGGAGAAACTTATCCTCAGGGGGCATGAGGTGGTTGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGGAAAATCACTGAATTGCACAGTGAAGACTTACTCAACCTCA
TACACTCTGGAGGATCTGGACCGGGAATTCATGGATTTCGCCGATGCTCAATGGAAAGCA
CAAGTACGAAGTTTGTTTTCTCTATTTCTGAGTTCATCCAATGGTTTTTTTAACTTATTT
TTTTCGCATTGCAGGAGTTTGTTTAATGACCGAAGATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCGGTGTTTCTTGATCCTTTTGATGCCTGTGCGTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCGCCAGGGGAATAGGTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGAATTCTCTTAGGGTTCTCAGATGCC
ATGGCTTTCAAGGAGAGAGTACGGAACCACATCTTGCACTTGGAGGAACATTTATTTTGC
CAGTATTTTTCCAAAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACACCTGTCACA
GCATATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACAGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAATATGATCTTCATTGGTGGTATCAACTGCCATCAGGGA
AAGCCATTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF030310

# Metabolic_Enzyme_4_Chromosome_Location:
Not Available

# Metabolic_Enzyme_4_Locus:
Not Available

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
9535849; 11434514; 12042666

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5733

# Metabolic_Enzyme_5_Name:
UDP-glucuronosyltransferase 1-5 precursor

# Metabolic_Enzyme_5_Synonyms:
UDP- glucuronosyltransferase 1A5; UDPGT; UGT1*5; UGT1-05; UGT1.5; UGT- 1E; UGT1E

# Metabolic_Enzyme_5_Gene_Name:
UGT1A5

# Metabolic_Enzyme_5_Protein_Sequence:
>UDPglucuronosyltransferase 15 precursor
MATGLQVPLPQLATGLLLLLSVQPWAESGKVLVVPTDGSHWLSMREALRDLHARGHQVVV
LTLEVNMYIKEENFFTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNM
SLIIHRSCVELLHNEALIRHLHATSFDVVLTDPFHLCAAVLAKYLSIPAVFFLRNIPCDL
DFKGTQCPNPSSYIPRLLTTNSDHMTFLQRVKNMLYPLALSYLCHAVSAPYASLASELFQ
REVSVVDLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_5_Number_of_Residues:
534

# Metabolic_Enzyme_5_Molecular_Weight:
60072

# Metabolic_Enzyme_5_Theoretical_pI:
8.14

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_5_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_5_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_5_Signals:
1-28

# Metabolic_Enzyme_5_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_5_GenBank_ID_Protein:
340139

# Metabolic_Enzyme_5_SwissProt_ID:
UD15_HUMAN (P35504)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
UGT1A5

# Metabolic_Enzyme_5_Geneatlas_id:
UGT1A5

# Metabolic_Enzyme_5_hgnc_id:
HGNC:12537

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Microsome

# Metabolic_Enzyme_5_Gene_Sequence:
>867 bp
ATGGCCACAGGACTCCAGGTTCCCCTGCCGCAGCTGGCCACAGGACTGCTGCTTCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGGAAGGTGCTGGTGGTGCCCACTGATGGCAGCCAC
TGGCTCAGCATGCGGGAGGCCTTGCGGGACCTCCATGCGAGAGGCCACCAGGTGGTGGTC
CTCACCCTGGAGGTGAATATGTACATCAAAGAAGAGAACTTTTTCACCCTGACAACGTAT
GCCATTTCATGGACCCAGGACGAATTTGATCGCCTTTTGCTGGGTCACACTCAATCGTTC
TTTGAAACAGAACATCTTCTGATGAAATTTTCTAGAAGAATGGCAATTATGAACAATATG
TCTTTGATCATACATAGGTCTTGTGTGGAGCTACTGCATAATGAGGCCCTGATCAGGCAC
CTGCATGCTACTTCCTTTGATGTGGTTCTAACAGACCCCTTTCACCTCTGCGCGGCGGTG
CTGGCTAAGTACCTGTCGATTCCTGCTGTGTTTTTCTTGAGGAACATTCCATGTGATTTA
GACTTTAAGGGCACACAGTGTCCAAACCCTTCCTCCTATATTCCTAGATTACTAACGACC
AATTCAGACCACATGACATTCCTGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACCTTTGCCATGCTGTTTCTGCTCCTTATGCAAGCCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATCTTGTCAGCCATGCATCTGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGATTACCCCAGGCCGATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACGGGAAGCCACTATCTCAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M84129

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_5_Locus:
2q37

# Metabolic_Enzyme_5_SNPs:
Not Available

# Metabolic_Enzyme_5_General_References:
1339448; 11434514

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5721

# Metabolic_Enzyme_6_Name:
UDP-glucuronosyltransferase 2B7 precursor

# Metabolic_Enzyme_6_Synonyms:
UDPGT; 3,4- catechol estrogen specific; UDPGTh-2

# Metabolic_Enzyme_6_Gene_Name:
UGT2B7

# Metabolic_Enzyme_6_Protein_Sequence:
>UDPglucuronosyltransferase 2B7 precursor
MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSA
SILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFG
DITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTF
EKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVL
GRPTTLSETMGKADVWLIRNSWNFQFPHPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSG
ENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTM
SSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND

# Metabolic_Enzyme_6_Number_of_Residues:
529

# Metabolic_Enzyme_6_Molecular_Weight:
60695

# Metabolic_Enzyme_6_Theoretical_pI:
8.45

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites

# Metabolic_Enzyme_6_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_6_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_6_Signals:
1-23

# Metabolic_Enzyme_6_Transmembrane_Regions:
493-509

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_6_GenBank_ID_Protein:
340080

# Metabolic_Enzyme_6_SwissProt_ID:
UDB7_HUMAN (P16662)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
UGT2B7

# Metabolic_Enzyme_6_Geneatlas_id:
UGT2B7

# Metabolic_Enzyme_6_hgnc_id:
HGNC:12554

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Microsome

# Metabolic_Enzyme_6_Gene_Sequence:
>1590 bp
ATGTCTGTGAAATGGACTTCAGTAATTTTGCTAATACAACTGAGCTTTTGCTTTAGCTCT
GGGAATTGTGGAAAGGTGCTGGTGTGGGCAGCAGAATACAGCCATTGGATGAATATAAAG
ACAATCCTGGATGAGCTTATTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAACAACTCATCCGCTCTTAAAATTGAAATTTATCCCACATCT
TTAACTAAAACTGAGTTGGAGAATTTCATCATGCAACAGATTAAGAGATGGTCAGACCTT
CCAAAAGATACATTTTGGTTATATTTTTCACAAGTACAGGAAATCATGTCAATATTTGGT
GACATAACTAGAAAGTTCTGTAAAGATGTAGTTTCAAATAAGAAATTTATGAAAAAAGTA
CAAGAGTCAAGATTTGACGTCATTTTTGCAGATGCTATTTTTCCCTGTAGTGAGCTGCTG
GCTGAGCTATTTAACATACCCTTTGTGTACAGTCTCAGCTTCTCTCCTGGCTACACTTTT
GAAAAGCATAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAGAA
TTAACTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTACTTT
GACTTTTGGTTCGAAATATTTGACATGAAGAAGTGGGATCAGTTTTATAGTGAAGTTCTA
GGAAGACCCACTACGTTATCTGAGACAATGGGGAAAGCTGACGTATGGCTTATTCGAAAC
TCCTGGAATTTTCAGTTTCCTCATCCACTCTTACCAAATGTTGATTTTGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTGCCTAAGGAAATGGAAGACTTTGTACAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGG
GCCAACGTAATTGCATCAGCCCTGGCCCAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATACCTTAGGTCTCAATACTCGGCTGTATAAGTGGATACCCCAGAAT
GACCTTCTAGGTCATCCAAAGACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TACGAGGCAATCTACCATGGGATCCCTATGGTGGGGATTCCATTGTTTGCCGATCAACCT
GATAACATTGCTCACATGAAGGCCAGGGGAGCAGCTGTTAGAGTGGACTTCAACACAATG
TCGAGTACAGACTTGCTGAATGCATTGAAGAGAGTAATTAATGATCCTTCATATAAAGAG
AATGTTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCTAAACACCTTCGGGTTGCAGCC
CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGTCTGT
GTGGCAACTGTGATATTTATCGTCACAAAATGTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGCAAAGAAGGGAAAAAATGATTAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
J05428

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_6_Locus:
4q13

# Metabolic_Enzyme_6_SNPs:
rs7439366; rs12233719; rs35590824; rs7438284; rs4348159; rs4292394; rs28365062; rs5013211; rs7686056; rs6600884; rs7441750; rs7439152; rs12513195; rs4293848; rs3924192; rs7442453; rs7698846; rs7678656; rs12506962; rs7441774; rs6600888; rs6858558; rs6600885; rs6600891; rs7375178; rs7435335; rs6600890; rs6600887; rs7438244; rs4521414; rs6600889; rs12647682; rs7434332; rs12508257; rs4694628; rs6600886; rs4314347; rs12647681; rs7439326; rs7698645; rs12512526; rs10028494; rs9995928; rs3924194; rs6600892; rs4364327; rs3924193; rs12642938; rs4337789; rs7679184; rs12648462; rs10050146; rs4257713; rs4588522; rs4356975; rs7693957; rs7658752; rs4314345; rs7438942; rs4351080; rs4541594; rs10006452; rs6851533; rs6600880; rs7438135; rs11940316; rs6600879; rs7668282; rs7668258; rs4538548; rs6600883; rs6600893; rs7662029; rs4455491; rs11940220; rs4554144; rs5859163; rs34620993; rs34851008; rs34308305; rs34661811; rs35327868; rs35893826; rs10022440; rs13136922; rs34407256; rs35452834; rs34095769; rs5859161; rs34241812; rs34302283; rs34386959; rs35475910; rs34561399; rs28675300; rs34556519; rs28673873; rs35185848; rs28539948; rs34571475; rs34318523; rs35402056; rs5859162; rs34182209; rs4694177; rs28375964; rs35605246; rs11302069; rs10008743; rs5859160; rs4356974; rs34630750; rs7437605; rs6819882; rs34590280; rs11249527; rs11249528; rs12506592; rs13118991; rs13135225; rs28365063; rs4274916; rs4358465; rs4434330; rs4535394; rs4694169; rs6422323; rs6422324; rs6600876; rs6843382; rs7437174; rs7657423; rs7676472

# Metabolic_Enzyme_6_General_References:
2159463; 11186130

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5719

# Metabolic_Enzyme_7_Name:
UDP-glucuronosyltransferase 1-4 precursor

# Metabolic_Enzyme_7_Synonyms:
UDP- glucuronosyltransferase 1A4; UDPGT; UGT1*4; UGT1-04; UGT1.4; UGT- 1D; UGT1D; Bilirubin-specific UDPGT isozyme 2; HUG-BR2

# Metabolic_Enzyme_7_Gene_Name:
UGT1A4

# Metabolic_Enzyme_7_Protein_Sequence:
>UDPglucuronosyltransferase 14 precursor
MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVV
LTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNV
SLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDL
DFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQ
REVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_7_Number_of_Residues:
534

# Metabolic_Enzyme_7_Molecular_Weight:
60026

# Metabolic_Enzyme_7_Theoretical_pI:
8.68

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

# Metabolic_Enzyme_7_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_7_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_7_Signals:
1-28

# Metabolic_Enzyme_7_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_7_GenBank_ID_Protein:
340137

# Metabolic_Enzyme_7_SwissProt_ID:
UD14_HUMAN (P22310)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
UGT1A4

# Metabolic_Enzyme_7_Geneatlas_id:
UGT1A4

# Metabolic_Enzyme_7_hgnc_id:
HGNC:12536

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Microsome

# Metabolic_Enzyme_7_Gene_Sequence:
>867 bp
ATGGCCAGAGGACTCCAGGTTCCCCTGCCGCGGCTGGCCACAGGACTGCTGCTCCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCACTGATGGCAGCCCC
TGGCTCAGCATGCGGGAGGCCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCGGTGGTC
CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAAATTTTTCACCCTGACAGCCTAT
GCTGTTCCATGGACCCAGAAGGAATTTGATCGCGTTACGCTGGGCTACACTCAAGGGTTC
TTTGAAACAGAACATCTTCTGAAGAGATATTCTAGAAGTATGGCAATTATGAACAATGTA
TCTTTGGCCCTTCATAGGTGTTGTGTGGAGCTACTGCATAATGAGGCCCTGATCAGGCAC
CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGTGGGGCGGTG
CTGGCTAAGTACCTGTCGATTCCTGCTGTGTTTTTTTGGAGGTACATTCCATGTGACTTA
GACTTTAAGGGCACACAGTGTCCAAATCCTTCCTCCTATATTCCTAAGTTACTAACGACC
AATTCAGACCACATGACATTCCTGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACATTTGCCATACTTTTTCTGCCCCTTATGCAAGTCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATCTTGTCAGCTATGCATCCGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGACTACCCCAGGCCGATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACGGGAAGCCACTATCTCAG

# Metabolic_Enzyme_7_GenBank_ID_Gene:
M84128

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_7_Locus:
2q37

# Metabolic_Enzyme_7_SNPs:
Not Available

# Metabolic_Enzyme_7_General_References:
1898728; 1339448; 11434514; 1634050; 8280139; 8276413

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
6127

# Metabolic_Enzyme_8_Name:
Estradiol 17-beta-dehydrogenase 3

# Metabolic_Enzyme_8_Synonyms:
17-beta-HSD 3; Testicular 17-beta-hydroxysteroid dehydrogenase

# Metabolic_Enzyme_8_Gene_Name:
HSD17B3

# Metabolic_Enzyme_8_Protein_Sequence:
>Estradiol 17betadehydrogenase 3
MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGI
GKAYSFELAK
RGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEK
LAGLEIGILVNNVGMLPNLLP
SHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKG
LILNISSGIALFPWPLYSMYSASKAFVCAFSK
ALQEEYKAKEVIIQVLTPYAVSTAMTK
YLNTNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSL
IPAWAFYSGAFQRLLL
THYVAYLKLNTKVR

# Metabolic_Enzyme_8_Number_of_Residues:
310

# Metabolic_Enzyme_8_Molecular_Weight:
34516

# Metabolic_Enzyme_8_Theoretical_pI:
8.84

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH

# Metabolic_Enzyme_8_Pathway:
map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_8_Reaction:
estradiol-17beta + NAD(P)+ = estrone + NAD(P)H + H+

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_8_Signals:
1-24

# Metabolic_Enzyme_8_Transmembrane_Regions:
178-200; 269-291

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.1.1.62

# Metabolic_Enzyme_8_GenBank_ID_Protein:
531162

# Metabolic_Enzyme_8_SwissProt_ID:
DHB3_HUMAN (P37058)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
HSD17B3

# Metabolic_Enzyme_8_Geneatlas_id:
HSD17B3

# Metabolic_Enzyme_8_hgnc_id:
HGNC:5212

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Membrane

# Metabolic_Enzyme_8_Gene_Sequence:
>933 bp

ATGGGGGACGTCCTGGAACAGTTCTTCATCCTCACAGGGCTGCTGGTGTGCCTGGCCTG
CCTGGCGAAGT
GCGTGAGATTCTCCAGATGTGTTTTACTGAACTACTGGAAAGTTTTGC
CAAAGTCTTTCTTGCGGTCAAT
GGGACAGTGGGCAGTGATCACTGGAGCAGGCGATGGA
ATTGGGAAAGCGTACTCGTTCGAGCTAGCAAAA
CGTGGACTCAATGTTGTCCTTATTAG
CCGGACGCTGGAAAAACTAGAGGCCATTGCCACAGAGATCGAGC
GGACTACAGGGAGGA
GTGTGAAGATTATACAAGCAGATTTTACAAAAGATGACATCTACGAGCATATTAA
AGAA
AAACTTGCAGGCTTAGAAATTGGAATTTTAGTCAACAATGTCGGAATGCTTCCAAACCTT
CTCCCA
AGCCATTTCCTGAACGCACCGGATGAAATCCAGAGCCTCATCCATTGTAACAT
CACCTCCGTAGTCAAGA
TGACACAGCTAATTCTGAAACATATGGAATCAAGGCAGAAAG
GTCTCATCCTGAACATTTCTTCTGGGAT
AGCCCTGTTTCCTTGGCCTCTCTACTCCATG
TACTCAGCTTCCAAGGCGTTTGTGTGCGCATTTTCCAAG
GCCCTGCAAGAGGAATATAA
AGCAAAAGAAGTCATCATCCAGGTGCTGACCCCATATGCTGTCTCGACTG
CAATGACAA
AGTATCTAAATACAAATGTGATAACCAAGACTGCTGATGAGTTTGTCAAAGAGTCATTGA
A
TTATGTCACAATTGGAGGTGAAACCTGTGGCTGCCTTGCCCATGAAATCTTGGCGGGC
TTTCTGAGCCTG
ATCCCGGCCTGGGCCTTCTACAGCGGTGCCTTCCAAAGGCTGCTCCT
GACACACTATGTGGCATACCTGA
AGCTCAACACCAAGGTCAGGTAG

# Metabolic_Enzyme_8_GenBank_ID_Gene:
U05659

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_8_Locus:
9q22

# Metabolic_Enzyme_8_SNPs:
rs2066480; rs2066479; rs2066478; rs8190555; rs35189151; rs2224864; rs2066474; rs2066484; rs2066476; rs35024493; rs2026001; rs371119; rs408876; rs999269; rs912463; rs912464; rs375411; rs2147253; rs7039978; rs8190508; rs2476921; rs2476920; rs729390; rs7022250; rs280654; rs8190531; rs2066475; rs8190566; rs6479179; rs7863067; rs416699; rs2243595; rs1927882; rs370438; rs9299363; rs1119864; rs8190513; rs8190542; rs8190541; rs912461; rs8190554; rs2476923; rs441402; rs867807; rs280658; rs2066473; rs10820247; rs2066485; rs8190522; rs1983828; rs2479825; rs407179; rs8190568; rs10125001; rs7037932; rs8190534; rs7868919; rs913580; rs7029101; rs280663; rs8190529; rs166819; rs2476927; rs8190490; rs2066483; rs4401999; rs10739847; rs8190496; rs379734; rs2479821; rs1886260; rs10820208; rs2256618; rs8190504; rs2066487; rs2066477; rs10990258; rs8190535; rs2257157; rs392312; rs12552648; rs7043341; rs8190483; rs8190569; rs1807197; rs2479828; rs2147252; rs8190512; rs2476922; rs8190523; rs11788083; rs7022826; rs280662; rs2066482; rs1810711; rs8190530; rs1927883; rs8190536; rs8190557; rs7873481; rs8190560; rs8190505; rs2987356; rs394243; rs2066486; rs2253502; rs4551481; rs16910680; rs2479824; rs8190549; rs375944; rs2183009; rs11788785; rs2479822; rs8190540; rs8190498; rs12682944; rs8190515; rs280656; rs8190501; rs35056365; rs8190551; rs8190488; rs2479823; rs2066481; rs10820245; rs1225274; rs10990247; rs8190492; rs7042971; rs8190484; rs10820228; rs11789467; rs7859733; rs8190556; rs35688278; rs7040523; rs11791650; rs8190506; rs8190533; rs8190493; rs8190487; rs11789867; rs8190544; rs280665; rs912462; rs8190537; rs12552750; rs8190559; rs8190561; rs2181820; rs400851; rs10990255; rs35567655; rs8190489; rs12683472; rs10117181; rs10820205; rs12684447; rs35638259; rs8190527; rs8190495; rs8190552; rs16910690; rs2476925; rs10820243; rs8190525; rs8190570; rs280657; rs8190500; rs35537194; rs10820188; rs10990236; rs10990246; rs8190497; rs8190514; rs3925451; rs8190532; rs7043452; rs280655; rs6479186; rs12553488; rs10990251; rs8190550; rs4269659; rs2770143; rs10820220; rs8190485; rs10990202; rs8190562; rs16910694; rs13302476; rs34258388; rs8190518; rs8190539; rs35264203; rs6479221; rs35920604; rs1571399; rs280664; rs11791540; rs12686518; rs10990201; rs12005851; rs10990208; rs35010891; rs2987360; rs9409407; rs10820242; rs8190486; rs2476926; rs10733725; rs10820289; rs2026003; rs4743709; rs7029369; rs7872344; rs7048229; rs8190482; rs8190573; rs8190575; rs8190574; rs8190480; rs8190576; rs1324196; rs8190580; rs7848739; rs8190481; rs28932191; rs35907896; rs4743704; rs8190478; rs8190571; rs7848833; rs8190479; rs7024573; rs28932190; rs8190577; rs8190579; rs34862233; rs12003404; rs34268513; rs10524217; rs34020460; rs7357770; rs35605750; rs1753313; rs5899284; rs28393240; rs12345460; rs8190491; rs34712901; rs34749486; rs12377687; rs34607511; rs34252191; rs10990269; rs11324337; rs10684729; rs35463519; rs34835687; rs10990237; rs435265; rs8190546; rs13286372; rs11410872; rs10119272; rs34768651; rs35760395; rs8190565; rs10990350; rs13284535; rs34919185; rs8190511; rs7042315; rs12345464; rs10990203; rs13292483; rs5899282; rs9409053; rs12337479; rs34328277; rs34696429; rs10990349; rs10639612; rs2296211; rs13297204; rs12345498; rs12345462; rs34057561; rs10615794; rs8190545; rs28401600; rs2296210; rs11301816; rs10990320; rs34430175; rs7357765; rs8190510; rs2985282; rs12347921; rs35605782; rs13301464; rs13289967; rs8190519; rs10990146; rs34410351; rs11789590; rs35645593; rs12349596; rs35806560; rs28623339; rs36102384; rs2987357; rs4495556; rs7038184; rs28565462; rs35918093; rs10990348; rs11453214; rs8190517; rs9657644; rs10120717; rs11496626; rs34442358; rs10680950; rs34372619; rs1571400; rs11789582; rs2985281; rs8190548; rs35522080; rs8190538; rs34131940; rs10990306; rs10559450; rs9777382; rs34981993; rs35343617; rs36069609; rs10639457; rs12335993; rs8190547; rs10624364; rs8190502; rs11496541; rs10990254; rs7045594; rs35535710; rs35600106; rs3831056; rs34042448; rs8190543; rs34058347; rs11335254; rs34430203; rs8190499; rs35816882; rs34162871; rs10990356; rs34441335; rs35307721; rs35659617; rs13284833; rs35962525; rs35214327; rs11281254; rs4743685; rs11417524; rs35427805; rs36117803; rs5899285; rs13284819; rs34800961; rs35280549; rs35941200; rs8190509; rs34358443; rs8190521; rs2183010; rs34280228; rs34975803; rs34156466; rs34593569; rs36018805; rs8190558; rs7037679; rs36086036; rs1125964; rs8190563; rs10545828; rs4266767; rs35309344; rs172169; rs35526475; rs8190507; rs33914106; rs5899283; rs182207; rs12345184; rs12339274; rs28523601; rs7357803; rs1238256; rs8190526; rs8190503; rs7869083; rs35263931; rs7852386; rs8190516; rs12345535; rs8190567; rs10990147; rs8190564; rs11515574; rs34686124; rs8190553; rs10990352; rs8190494; rs34577755; rs34024715; rs35689970; rs12342506; rs28421370; rs34355657; rs34140038; rs10541572; rs12338600; rs34849790; rs34051033; rs34240849; rs7049076; rs34912237; rs8190578; rs35789085; rs35188473; rs7045272; rs34721662; rs34190050; rs1408326; rs11327991; rs34108147; rs11286201; rs11789857; rs28931868; rs11307544; rs35917801; rs34037771; rs10820299; rs10820300; rs10990385; rs11788621; rs12350632; rs12552312; rs12555788; rs1887774; rs1887775; rs1927886; rs2025444; rs2031320; rs2031321; rs2476919; rs2479827; rs280661; rs33951726; rs34491501; rs3949818; rs4742910; rs4743712; rs4743713; rs4743715; rs7026934; rs7037304; rs7045639; rs8190581; rs9299367; rs958829; rs958830; rs958831

# Metabolic_Enzyme_8_General_References:
8075637; 8550739; 9758445; 9709959; 11158067

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5724

# Metabolic_Enzyme_9_Name:
UDP-glucuronosyltransferase 2A1 precursor

# Metabolic_Enzyme_9_Synonyms:
Not Available

# Metabolic_Enzyme_9_Gene_Name:
UGT2A1

# Metabolic_Enzyme_9_Protein_Sequence:
>UDPglucuronosyltransferase 2A1 precursor
MLNNLLLFSLQISLIGTTLGGNVLIWPMEGSHWLNVKIIIDELIKKEHNVTVLVASGALF
ITPTSNPSLTFEIYKVPFGKERIEGVIKDFVSTWLENRPSPSTIWRFYQEMAKVIKDFHM
VSQEICDGVLKNQQLMAKLKKSKFEVLVSDPVFPCGDIVALKLGIPFMYSLRFSPASTVE
KHCGKVPYPPSYVPAVLSELTDQMSFTDRIRNFISYHLQDYMFETLWKSWDSYYSKALGR
PTTLCETMGKAEIWLIRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFIQSSGKN
GVVVFSLGSMVKNLTEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDL
LGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTS
VDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHD
LTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKFGKIGKKKKRE

# Metabolic_Enzyme_9_Number_of_Residues:
527

# Metabolic_Enzyme_9_Molecular_Weight:
59873

# Metabolic_Enzyme_9_Theoretical_pI:
9.29

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform is active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium

# Metabolic_Enzyme_9_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_9_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_9_Signals:
1-20

# Metabolic_Enzyme_9_Transmembrane_Regions:
491-507

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_9_GenBank_ID_Protein:
4753766

# Metabolic_Enzyme_9_SwissProt_ID:
UDA1_HUMAN (Q9Y4X1)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
UGT2A1

# Metabolic_Enzyme_9_Geneatlas_id:
UGT2A1

# Metabolic_Enzyme_9_hgnc_id:
HGNC:12542

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Membrane

# Metabolic_Enzyme_9_Gene_Sequence:
>1584 bp
ATGTTAAACAACCTTCTGCTGTTCTCCCTTCAGATAAGTCTCATAGGAACCACTCTTGGT
GGGAATGTTTTGATTTGGCCAATGGAAGGTAGTCATTGGCTAAATGTTAAGATAATTATA
GATGAGCTCATTAAAAAGGAGCATAATGTGACTGTCCTAGTTGCCTCTGGTGCACTTTTC
ATCACACCAACCTCTAACCCATCTCTGACATTTGAAATATATAAGGTGCCCTTTGGCAAA
GAAAGAATAGAAGGAGTAATTAAGGACTTCGTTTCGACATGGCTGGAAAATAGACCATCT
CCTTCAACCATTTGGAGATTCTATCAGGAGATGGCCAAAGTAATCAAGGACTTCCACATG
GTGTCTCAGGAGATCTGTGATGGCGTTCTTAAAAACCAACAGCTGATGGCAAAGCTAAAG
AAAAGCAAGTTTGAAGTCCTGGTGTCTGATCCAGTATTTCCTTGTGGCGATATAGTAGCT
TTAAAACTTGGAATTCCATTTATGTACTCCTTGAGGTTTTCTCCAGCCTCAACAGTGGAA
AAGCACTGTGGGAAGGTACCATACCCTCCTTCCTATGTTCCTGCTGTTTTATCAGAACTC
ACCGACCAAATGTCTTTCACTGACAGAATAAGAAATTTCATCTCCTACCACCTACAGGAC
TACATGTTTGAAACTCTTTGGAAATCATGGGATTCATACTATAGTAAAGCTTTAGGAAGA
CCCACTACGTTATGTGAGACTATGGGGAAAGCTGAAATTTGGTTAATCCGAACATATTGG
GATTTTGAATTTCCTCGTCCATACTTACCTAATTTTGAGTTTGTTGGAGGATTGCACTGC
AAACCTGCCAAACCTTTACCTAAGGAAATGGAAGAATTTATCCAGAGCTCAGGTAAAAAT
GGTGTTGTGGTGTTTTCTCTGGGATCAATGGTCAAAAACCTTACAGAAGAAAAGGCCAAT
CTTATTGCCTCAGCCCTTGCCCAGATTCCACAGAAGGTTTTATGGAGATACAAAGGAAAG
AAACCAGCCACATTAGGAAACAATACTCAGCTCTTTGATTGGATACCCCAGAATGATCTT
CTTGGACATCCCAAAACCAAAGCTTTTATCACTCATGGTGGAACTAATGGGATCTACGAA
GCTATTTACCACGGAGTCCCTATGGTGGGAGTTCCCATGTTTGCTGATCAGCCTGATAAC
ATTGCTCACATGAAGGCCAAAGGAGCAGCTGTGGAAGTGAACCTAAACACAATGACAAGT
GTGGATTTGCTTAGCGCTTTGAGAACAGTCATTAATGAACCTTCTTATAAAGAGAATGCT
ATGAGGTTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTGGATCGAGCAGTCTTC
TGGATCGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTTCGGGTTGCAGCCCATGAC
CTCACCTGGTTCCAGTACCACTCTTTGGATGTAATTGGGTTCTTGCTGGTCTGTGTGACA
ACGGCTATATTTTTGGTCATACAATGTTGTTTGTTTTCCTGTCAAAAATTTGGTAAGATA
GGAAAGAAGAAAAAAAGAGAATAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AJ006054

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_9_Locus:
4q13

# Metabolic_Enzyme_9_SNPs:
rs4148301; rs4148304; rs2163659; rs7668703; rs1432329; rs1432332; rs7659937; rs7672805; rs979363; rs10000435; rs4148279; rs10028495; rs7656541; rs6835972; rs4148276; rs1432330; rs4148277; rs6600796; rs1821185; rs1432335; rs1432336; rs1319811; rs7671313; rs10903210; rs7689493; rs10013528; rs9992698; rs988671; rs6842466; rs6825253; rs4148291; rs11728546; rs2331685; rs2017370; rs4694225; rs6832424; rs6600793; rs1432324; rs1560605; rs2163658; rs4148308; rs4401516; rs6600794; rs988672; rs3775783; rs1036160; rs7655867; rs6854350; rs1835826; rs4148295; rs2288740; rs2288741; rs1438537; rs1432316; rs6853543; rs11249451; rs1158439; rs4148281; rs10001991; rs11946382; rs10518063; rs2033798; rs6600792; rs4048747; rs1432314; rs10033801; rs7676249; rs10026988; rs10028954; rs7662867; rs1432315; rs11249452; rs1835821; rs10006049; rs4148289; rs10011630; rs7662309; rs4148298; rs10021575; rs17147507; rs9999694; rs6846404; rs4694219; rs17147542; rs7692074; rs10023821; rs11933160; rs7662915; rs1967984; rs6855271; rs4148292; rs11249454; rs10033879; rs1432313; rs7685874; rs17147532; rs7665571; rs11736315; rs4473712; rs10023782; rs4694222; rs7670819; rs7699881; rs6824954; rs11936310; rs11936130; rs6600795; rs1432327; rs10011912; rs3822178; rs1835829; rs9999430; rs6848997; rs1835822; rs11942157; rs4148290; rs17674565; rs17674511; rs10004306; rs6811810; rs4148297; rs17618404; rs1583243; rs6858314; rs10012508; rs6832784; rs2217587; rs3775782; rs12507278; rs6855294; rs17147530; rs11731188; rs10009530; rs6824830; rs13129549; rs6831807; rs11736373; rs10006483; rs17618520; rs17680131; rs7680856; rs4148286; rs11931365; rs10023877; rs17618178; rs11722780; rs10027493; rs6826237; rs17147521; rs11249453; rs7688383; rs4148299; rs4148302; rs9997689; rs6814603; rs7681367; rs17674648; rs9917881; rs4148296; rs11721934; rs4148283; rs6849110; rs12501520; rs4148307; rs11736353; rs13120401; rs4550998; rs4148309; rs6839067; rs6852329; rs7670238; rs7668967; rs11946584; rs10022954; rs6832167; rs2010207; rs12500392; rs7690649; rs17617467; rs10013712; rs9993182; rs6846030; rs4148305; rs17618230; rs10026603; rs4694027; rs4148288; rs6831951; rs11730451; rs10005934; rs1897441; rs4395582; rs11729544; rs4148312; rs4280808; rs10518065; rs11929943; rs11929908; rs10033854; rs17147557; rs1550292; rs13134357; rs11939884; rs1432334; rs1432333; rs17619211; rs17681080; rs10471252; rs1347046; rs41292307; rs4148310; rs41292305; rs35926238; rs4148275; rs7674020; rs35816431; rs34251717; rs11438429; rs4148311; rs4694226; rs1368116; rs35378505; rs34607614; rs4148278; rs10649712; rs10682826; rs188964; rs11732515; rs192970; rs11725441; rs28448316; rs33924396; rs28798793; rs17147492; rs324309; rs28413749; rs17147503; rs17147534; rs28404221; rs6600791; rs28570072; rs33943659; rs34090224; rs35971542; rs11460578; rs33999522; rs11441625; rs11323266; rs35281757; rs7677083; rs28776197; rs28782228; rs35910775; rs10583998; rs12644575; rs1967983; rs34446108; rs34142192; rs28544323; rs4148294; rs35582043; rs189787; rs4148285; rs11931171; rs2033801; rs11319385; rs11279957; rs5859193; rs324313; rs4148282; rs33938194; rs7377236; rs34704021; rs36106673; rs28818211; rs28532778; rs34265777; rs4148303; rs13119853; rs36003863; rs1583242; rs34513233; rs985040; rs7686386; rs10691812; rs34650072; rs13112999; rs11721725; rs28759827; rs28726183; rs34028035; rs324310; rs4409023; rs4148320; rs13131759; rs33953975; rs17147520; rs36051343; rs35795947; rs7672793; rs36163528; rs34021488; rs11733854; rs11721681; rs7669007; rs13149874; rs4148322; rs36083211; rs34789624; rs35333044; rs28560222; rs7693686; rs34698455; rs4148306; rs7657761; rs34909158; rs5859194; rs34670944; rs35243459; rs34139484; rs35400584; rs28689093; rs188966; rs11946796; rs11947056; rs11733907; rs28568390; rs34647023; rs10010846; rs6813494; rs7698372; rs28716091; rs10023818; rs35302832; rs34810925; rs34370025; rs4148313; rs4148287; rs34213902; rs35487350; rs35071017; rs10569499; rs33913173; rs28522985; rs34858243; rs28556671; rs34208726; rs34396917; rs4148284; rs11728785; rs28560191; rs28513556; rs28508252; rs36191379; rs4148316; rs4148280; rs4148293; rs7668214; rs2877457; rs34817437; rs2116564; rs11940905; rs10017134; rs28528833; rs35101874; rs33976214; rs34975164; rs34590689; rs34452487; rs2043241; rs3074345; rs35227598; rs34012364; rs34002846; rs28744454; rs34078716; rs34062331; rs5859195; rs35000204; rs33992705; rs10031145; rs33924614; rs11937993; rs13115454; rs1347047; rs1432317; rs1835830; rs4333255; rs6810459; rs7671030; rs7671041; rs7674562; rs7694939; rs9329029; rs9996459

# Metabolic_Enzyme_9_General_References:
10359671

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5734

# Metabolic_Enzyme_10_Name:
UDP-glucuronosyltransferase 2B11 precursor

# Metabolic_Enzyme_10_Synonyms:
UDPGT

# Metabolic_Enzyme_10_Gene_Name:
UGT2B11

# Metabolic_Enzyme_10_Protein_Sequence:
>UDPglucuronosyltransferase 2B11 precursor
MTLKWTSVLLLIHLSCYFSSGSCGKVLVWAAEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDASTLKFEVYPTSLTKTEFENIIMQQVKRWSDIRKDSFWLYFSQEQEILWELY
DIFRNFCKDVVSNKKVMKKLQESRFDIVFADAVFPCGELLAALLNIRFVYSLRFTPGYTI
ERHSGGLIFPPSYIPIVMSKLSDQMTFMERVKNMIYVLYFDFWFQMSDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNVDFVGGFHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRLDFNTM
SSTDLLNALKTVINDPLYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMPHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLACVATVIFIITKFCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_10_Number_of_Residues:
529

# Metabolic_Enzyme_10_Molecular_Weight:
61039

# Metabolic_Enzyme_10_Theoretical_pI:
9.29

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_10_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_10_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_10_Signals:
1-21

# Metabolic_Enzyme_10_Transmembrane_Regions:
493-513

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_10_GenBank_ID_Protein:
3360273

# Metabolic_Enzyme_10_SwissProt_ID:
UDB11_HUMAN (O75310)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
UGT2B11

# Metabolic_Enzyme_10_Geneatlas_id:
UGT2B11

# Metabolic_Enzyme_10_hgnc_id:
HGNC:12545

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Microsome

# Metabolic_Enzyme_10_Gene_Sequence:
>1590 bp
ATGACTCTGAAATGGACTTCAGTTCTTCTGCTGATACATCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAAGTGCTGGTGTGGGCCGCAGAATACAGCCATTGGATGAATATGAAG
ACAATCCTGAAAGAGCTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAATGATGCATCCACTCTTAAATTTGAAGTTTATCCTACATCT
TTAACTAAAACTGAATTTGAGAATATCATCATGCAACAGGTTAAGAGATGGTCAGACATT
CGAAAAGATAGCTTTTGGTTATATTTTTCACAAGAACAAGAAATCCTGTGGGAATTATAT
GACATATTTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAAGTTATGAAAAAACTA
CAAGAGTCAAGATTTGACATCGTTTTTGCAGATGCTGTTTTTCCCTGTGGTGAGCTGCTG
GCTGCGCTACTTAACATACGGTTTGTGTACAGTCTCCGCTTTACTCCTGGCTACACAATT
GAAAGGCACAGTGGAGGACTGATTTTCCCTCCTTCCTACATACCTATTGTTATGTCAAAA
TTAAGTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTATTTT
GACTTTTGGTTCCAAATGTCTGATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTA
GGAAGACCCACTACCTTATTTGAGACAATGGGAAAAGCTGACATATGGCTTATGCGAAAC
TCCTGGAGTTTTCAATTTCCTCATCCATTCTTACCAAACGTTGATTTTGTTGGAGGATTC
CACTGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAGTTTGTACAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAGTGATAAGTAACATGACAGCAGAAAGG
GCCAATGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAC
GGGAATAAACCAGATGCCTTAGGTCTCAATACTCGGCTGTACAAGTGGATACCCCAGAAT
GACCTTCTAGGTCATCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATGAGGCAATCTACCATGGGATCCCTATGGTGGGCATTCCATTGTTTTTTGATCAACCT
GATAACATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGATTGGACTTCAACACAATG
TCGAGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTTATATAAAGAG
AATATTATGAAATTATCAAGAATTCAACATGATCAACCAGTAAAGCCCCTGGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCCCCACAAAGGAGCCAAACACCTTCGAGTTGCAGCC
CATGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTTCTGCTGGCCTGT
GTGGCAACTGTGATATTTATCATCACAAAGTTTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGGGAAGAAGGGAAAAAGAGATTAG

# Metabolic_Enzyme_10_GenBank_ID_Gene:
AF016492

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_10_Locus:
4q13.2

# Metabolic_Enzyme_10_SNPs:
rs4694697; rs4415023; rs4400059; rs4543201; rs4283741; rs11945946; rs7436729; rs11947293; rs4463131; rs6833028; rs12500268; rs4608875; rs7688262; rs7697037; rs3890590; rs7697482; rs35248576; rs11340393; rs5859168; rs4485863; rs28743034; rs4619960; rs13148581; rs13113479; rs4406085; rs34519957; rs13119196; rs28561592; rs4406086; rs13134572; rs7660257; rs13148525; rs35902951; rs13148376; rs4386666; rs13134364; rs13113695; rs4485864; rs13107183; rs7660248; rs13119170; rs13103028; rs13134363; rs35555504; rs13139597; rs35443238; rs28470680; rs13113271; rs13119197; rs13107219; rs10007587; rs4466107; rs10434518; rs34416320; rs10007579; rs6847476; rs10012181; rs9996390; rs12502502; rs13123057; rs4526045; rs4694199; rs6817250; rs6825376; rs7672567; rs7682460; rs7695331

# Metabolic_Enzyme_10_General_References:
9675083

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5687

# Metabolic_Enzyme_11_Name:
UDP-glucuronosyltransferase 2B28 precursor

# Metabolic_Enzyme_11_Synonyms:
UDPGT

# Metabolic_Enzyme_11_Gene_Name:
UGT2B28

# Metabolic_Enzyme_11_Protein_Sequence:
>UDPglucuronosyltransferase 2B28 precursor
MALKWTSVLLLIHLGCYFSSGSCGKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDIQKDSFWLYFSQEQEILWEFH
DIFRNFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTI
ERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWFQMCDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTM
SSTDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAA
RDLTWFQYHSLDVIGFLLACVATVIFVVTKFCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_11_Number_of_Residues:
529

# Metabolic_Enzyme_11_Molecular_Weight:
60907

# Metabolic_Enzyme_11_Theoretical_pI:
8.80

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta- diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active

# Metabolic_Enzyme_11_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_11_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_11_Signals:
1-24

# Metabolic_Enzyme_11_Transmembrane_Regions:
495-517

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_11_GenBank_ID_Protein:
13603476

# Metabolic_Enzyme_11_SwissProt_ID:
UDB28_HUMAN (Q9BY64)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
UGT2B28

# Metabolic_Enzyme_11_Geneatlas_id:
UGT2B28

# Metabolic_Enzyme_11_hgnc_id:
HGNC:13479

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Microsome

# Metabolic_Enzyme_11_Gene_Sequence:
>1590 bp
ATGGCTCTGAAGTGGACTTCAGTTCTTCTGCTGATACATCTCGGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGACCGGTGAATACAGCCATTGGATGAATATGAAG
ACAATCCTGAAAGAGCTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAATGACGCATTCACTCTTAAACTCGAAGTTTATCCTACATCT
TTAACTAAAACTGAATTTGAGAATATCATCATGCAACAGGTTAAGAGATGGTCAGACATT
CAAAAAGATAGCTTTTGGTTATATTTTTCACAAGAACAAGAAATCCTGTGGGAATTTCAT
GACATATTTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAAGTTATGAAAAAACTA
CAAGAGTCAAGATTTGACATCATTTTTGCAGATGCTTTTTTTCCTTGTGGTGAGCTGCTG
GCTGCGCTACTTAACATACCGTTTGTGTACAGTCTCTGCTTCACTCCTGGCTACACAATT
GAAAGGCACAGTGGAGGACTGATTTTCCCTCCTTCCTACATACCTGTTGTTATGTCAAAA
TTAAGTGATCAAATGACTTTCATGGAGAGGGTAAAAAACATGATCTATGTGCTTTATTTT
GACTTTTGGTTCCAAATGTGTGATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTA
GGAAGACCCACTACCTTATTTGAGACAATGGGGAAAGCTGACATATGGCTTATGCGAAAC
TCCTGGAGTTTTCAATTTCCTCATCCATTCTTACCAAACATTGATTTTGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAATTTGTACAGAGCTCTGGT
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAGTGATAAGTAACATGACAGCAGAAAGG
GCCAACGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATGCCTTAGGTCTCAATACTCGGCTGTATAAGTGGATACCCCAGAAT
GACCTTCTAGGTCTTCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATGAGGCAATCTACCATGGGATCCCTATGGTAGGCATTCCATTGTTTTGGGATCAACCT
GATAACATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGACTGGACTTCCACACAATG
TCGAGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTCATATAAAGAG
AATGTTATGAAATTATCAATAATTCAACATGATCAACCAGTAAAGCCCCTGCATCGAGCA
GTCTTCTGGATTGAATTTGTGATGTGCCACAAAGGAGCCAAACACCTTCGAGTTGCAGCC
CGTGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTTCTGCTGGCCTGT
GTGGCAACTGTGATATTTGTCGTCACAAAGTTTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGGGAAGAAGGGAAAAAGAGATTAG

# Metabolic_Enzyme_11_GenBank_ID_Gene:
AF177272

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_11_Locus:
4q13.2

# Metabolic_Enzyme_11_SNPs:
rs4235127; rs4260604; rs4386668; rs11726210; rs10002503; rs4235126; rs3901337; rs4260603; rs10008843; rs4694712; rs4301173; rs4694711; rs2132039; rs9997242; rs4260602; rs4235125; rs4694713; rs7686786; rs10000077; rs7437560; rs7681187; rs10023367; rs7657406; rs41292949; rs6843900; rs6828191; rs41292951; rs10013145; rs7689398; rs41292341; rs13139691; rs13138824; rs4569811; rs6827801; rs34313836; rs5004177; rs28376412; rs13108235; rs5004180; rs4295327; rs4568294; rs4450998; rs33966513; rs5004176; rs35191928; rs13107778; rs4345242; rs34549399; rs4495113; rs5004183; rs41292945; rs41292947; rs35437714; rs35925451; rs13146763; rs28447469; rs35059283; rs5004182; rs7435249; rs5004175; rs5859170; rs4515230; rs6840320; rs35572829; rs5004178; rs5004179; rs4597901; rs41292339; rs5004181; rs13116501; rs10011666; rs41292343; rs7657045; rs13124875; rs9991645; rs35680160; rs6600920

# Metabolic_Enzyme_11_General_References:
11300766

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5725

# Metabolic_Enzyme_12_Name:
UDP-glucuronosyltransferase 1-1 precursor

# Metabolic_Enzyme_12_Synonyms:
UDP- glucuronosyltransferase 1A1; UDPGT; UGT1*1; UGT1-01; UGT1.1; UGT- 1A; UGT1A; Bilirubin-specific UDPGT isozyme 1; HUG-BR1

# Metabolic_Enzyme_12_Gene_Name:
UGT1A1

# Metabolic_Enzyme_12_Protein_Sequence:
>UDPglucuronosyltransferase 11 precursor
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_12_Number_of_Residues:
533

# Metabolic_Enzyme_12_Molecular_Weight:
59592

# Metabolic_Enzyme_12_Theoretical_pI:
8.09

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_12_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

# Metabolic_Enzyme_12_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_12_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_12_Signals:
1-25

# Metabolic_Enzyme_12_Transmembrane_Regions:
491-507

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_12_GenBank_ID_Protein:
184473

# Metabolic_Enzyme_12_SwissProt_ID:
UD11_HUMAN (P22309)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
UGT1A1

# Metabolic_Enzyme_12_Geneatlas_id:
UGT1A1

# Metabolic_Enzyme_12_hgnc_id:
HGNC:12530

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Microsome

# Metabolic_Enzyme_12_Gene_Sequence:
>1602 bp
ATGGCTGTGGAGTCCCAGGGCGGACGCCCACTTGTCCTGGGCCTGCTGCTGTGTGTGCTG
GGCCCAGTGGTGTCCCATGCTGGGAAGATACTGTTGATCCCAGTGGATGGCAGCCACTGG
CTGAGCATGCTTGGGGCCATCCAGCAGCTGCAGCAGAGGGGACATGAAATAGTTGTCCTA
GCACCTGACGCCTCGTTGTACATCAGAGACGGAGCATTTTACACCTTGAAGACGTACCCT
GTGCCATTCCAAAGGGAGGATGTGAAAGAGTCTTTTGTTAGTCTCGGGCATAATGTTTTT
GAGAATGATTCTTTCCTGCAGCGTGTGATCAAAACATACAAGAAAATAAAAAAGGACTCT
GCTATGCTTTTGTCTGGCTGTTCCCACTTACTGCACAACAAGGAGCTCATGGCCTCCCTG
GCAGAAAGCAGCTTTGATGTCATGCTGACGGACCCTTTCCTTCCTTGCAGCCCCATCGTG
GCCCAGTACCTGTCTCTGCCCACTGTATTCTTCTTGCATGCACTGCCATGCAGCCTGGAA
TTTGAGGCTACCCAGTGCCCCAACCCATTCTCCTACGTGCCCAGGCCTCTCTCCTCTCAT
TCAGATCACATGACCTTCCTGCAGCGGGTGAAGAACATGCTCATTGCCTTTTCACAGAAC
TTTCTGTGCGACGTGGTTTATTCCCCGTATGCAACCCTTGCCTCAGAATTCCTTCAGAGA
GAGGTGACTGTCCAGGACCTATTGAGCTCTGCATCTGTCTGGCTGTTTAGAAGTGACTTT
GTGAAGGATTACCCTAGGCCCATCATGCCCAATATGGTTTTTGTTGGTGGAATCAACTGC
CTTCACCAAAATCCACTATCCCAGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACAT
GGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATG
GCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACC
CGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTG
CTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAA
AGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAAT
GCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCT
GAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATC
ATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTC
TGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGAC
CTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTG
ACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAA
AAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
M57899

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_12_Locus:
2q37

# Metabolic_Enzyme_12_SNPs:
Not Available

# Metabolic_Enzyme_12_General_References:
1898728; 1339448; 11434514; 1634050; 8280139; 8276413; 8226884; 7989045; 7989595; 7715297; 9621515; 9627603

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5696

# Metabolic_Enzyme_13_Name:
UDP-glucuronosyltransferase 2B4 precursor

# Metabolic_Enzyme_13_Synonyms:
UDPGT; Hyodeoxycholic acid; HLUG25; UDPGTh-1

# Metabolic_Enzyme_13_Gene_Name:
UGT2B4

# Metabolic_Enzyme_13_Protein_Sequence:
>UDPglucuronosyltransferase 2B4 precursor
MSMKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLASSA
SISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFN
DILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFGELLAELLKIPFVYSLRFSPGYAI
EKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVL
GRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSMVSNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTM
SSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVTGFLLACVATVIFIITKCLFCVWKFVRTGKKGKRD

# Metabolic_Enzyme_13_Number_of_Residues:
528

# Metabolic_Enzyme_13_Molecular_Weight:
60513

# Metabolic_Enzyme_13_Theoretical_pI:
8.75

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_13_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid

# Metabolic_Enzyme_13_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_13_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_13_Signals:
1-23

# Metabolic_Enzyme_13_Transmembrane_Regions:
493-509

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_13_GenBank_ID_Protein:
37589

# Metabolic_Enzyme_13_SwissProt_ID:
UDB4_HUMAN (P06133)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
UGT2B4

# Metabolic_Enzyme_13_Geneatlas_id:
UGT2B4

# Metabolic_Enzyme_13_hgnc_id:
HGNC:12553

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Microsome

# Metabolic_Enzyme_13_Gene_Sequence:
>1587 bp
ATGTCTATGAAATGGACTTCAGCTCTTCTGCTGATACAGCTGAGCTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATTCAGCCACTGGATGAATATAAAG
ACAATCCTGGATGAACTTGTCCAGAGAGGTCATGAGGTGACTGTATTGGCATCTTCAGCT
TCCATTTCTTTCGATCCCAACAGCCCATCTACTCTTAAATTTGAAGTTTATCCTGTATCT
TTAACTAAAACTGAGTTTGAGGATATTATCAAGCAGCTGGTTAAGAGATGGGCAGAACTT
CCAAAAGACACATTTTGGTCATATTTTTCACAAGTACAAGAAATCATGTGGACATTTAAT
GACATACTTAGAAAGTTCTGTAAGGATATAGTTTCAAATAAGAAACTTATGAAGAAACTA
CAGGAGTCAAGATTTGATGTTGTTCTTGCAGATGCTGTTTTCCCCTTTGGTGAGCTGCTG
GCCGAGTTACTTAAAATACCCTTTGTCTACAGGCCTCGCTTCTCTCCTGGCTACGCAATT
GAAAAGCATAGTGGAGGACTTCTGTTCCCTCCTTCCTATGTGCCTGTTGTTATGTCAGAA
CTAAGTGACCAAATGACTTTCATAGAGAGGGTAAAAAATATGATCTATGTGCTTTATTTT
GAATTTTGGTTCCAAATATTTGACATGAAGAAGTGGGATCAGTTCTACAGTGAAGTTCTA
GGAAGACCCACTACGTTATCTGAGACAATGGCAAAAGCTGACATATGGCTTATTCGAAAC
TACTGGGATTTTCAATTTCCTCACCCACTCTTACCAAATGTTGAGTTCGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTACCGAAGGAAATGGAAGAGTTTGTCCAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCGATGGTCAGTAACACGTCAGAAGAAAGG
GCCAATGTAATTGCATCAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATACTTTAGGACTCAATACTCGGCTGTACAAGTGGATACCCCAGAAT
GATCTTCTTGGTCACCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATAAGGCAATCTCTCCTAGAATCCCTATGGTGGGCGTTCCATTGTTTGCAGATCAACCT
GATAACATTGCACACATGAAGGCCAAGGGAGCAGCTGTTAGTTTGGACTTCCACACAATG
TCGAGTACAGACTTACTCAATGCACTGAAGACAGTAATTAATGATCCTTTATATAAAGAG
AATGCTATGAAATTATCAAGAATTCATCATGATCAACCAGTGAAGCCCCTTGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTTGCAGCC
CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGACTGGGTTCCTGCTGGCCTGT
GTGGCAACTGTGATATTCATCATCACAAAATGTCTGTTTTGTGTCTGGAAGTTTGTTAGA
ACAGGAAAGAAGGGGAAAAGAGATTAA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
Y00317

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_13_Locus:
4q13

# Metabolic_Enzyme_13_SNPs:
rs13119049; rs41297431; rs13142440; rs1131878; rs1966151; rs1051752; rs7662902; rs1389930; rs1826690; rs7441743; rs1039007; rs2220857; rs2013562; rs1845557; rs6833511; rs13116232; rs12645716; rs9997034; rs1994936; rs1039008; rs4554145; rs28542932; rs10030234; rs10518061; rs17614939; rs13104260; rs10010875; rs3822179; rs33914959; rs1845556; rs6848208; rs17671289; rs1977017; rs28361541; rs41297733; rs41297437; rs1997581; rs41297373; rs41299996; rs41297395; rs41297371; rs41300016; rs41297381; rs41297421; rs1908406; rs41297427; rs41297377; rs41297425; rs41297367; rs4557343; rs1845558; rs3075630; rs41297405; rs41297739; rs41297383; rs41297721; rs13151870; rs41297441; rs13145834; rs13104687; rs11249442; rs41297407; rs41297429; rs41297727; rs1121124; rs2013573; rs41299994; rs13139888; rs41297439; rs41297409; rs1494802; rs13111134; rs6600771; rs6820660; rs6821129; rs941389; rs2736446; rs1080755; rs2736442; rs28858389; rs2736441; rs41298271; rs41298263; rs41299972; rs41298261; rs41298251; rs13129471; rs41299970; rs6821910; rs41298253; rs41298259; rs41298265; rs41298245; rs41299978; rs41299976; rs41299974; rs41300004; rs17852375; rs1845555; rs41298247; rs28679647; rs324405; rs41300006; rs36048401; rs1432328; rs41297387; rs41299984; rs41299998; rs41299992; rs41297735; rs41297423; rs35143721; rs1370886; rs41299980; rs41297389; rs41297729; rs7441132; rs41297435; rs34002802; rs41297731; rs41300018; rs35138624; rs41297391; rs41297369; rs41297737; rs41297413; rs13141359; rs41292303; rs41300008; rs2736447; rs41300014; rs41297401; rs34874998; rs1370887; rs41297399; rs41297379; rs172861; rs41297375; rs10613760; rs41297433; rs41297723; rs41297403; rs41297741; rs1821190; rs34030380; rs324406; rs41299986; rs41297393; rs41297385; rs41297419; rs41297365; rs35471760; rs34861432; rs4515233; rs324408; rs41297411; rs2018304; rs41300012; rs13114834; rs41297415; rs28629208; rs41300002; rs41300000; rs41300010; rs41297743; rs41297397; rs41299990; rs28419590; rs983988; rs34164957; rs1370885; rs324407; rs34466016; rs41297725; rs41297417; rs34114694; rs41299988; rs41299982; rs41299966; rs34846583; rs35045255; rs35834953; rs34169605; rs1318156; rs2642856; rs35159034; rs41298257; rs41298249; rs2736445; rs3075626; rs41299968; rs28847667; rs34146174; rs36057237; rs28812576; rs941390; rs41298255; rs28894673; rs41298269; rs1080756; rs41298267; rs10000231; rs10015297; rs11725944; rs11725945; rs13141436; rs13143630; rs1569343; rs1569344; rs1594588; rs1603119; rs1948499; rs2010468; rs2642849; rs2642872; rs2736462; rs2736476; rs2736517; rs2736520; rs35347166; rs4694749; rs7657880; rs903445; rs903446; rs9996511

# Metabolic_Enzyme_13_General_References:
3109396; 8333863; 10376768

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5685

# Metabolic_Enzyme_14_Name:
Estradiol 17-beta-dehydrogenase 2

# Metabolic_Enzyme_14_Synonyms:
17-beta-HSD 2; Microsomal 17-beta-hydroxysteroid dehydrogenase; 20 alpha- hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH

# Metabolic_Enzyme_14_Gene_Name:
HSD17B2

# Metabolic_Enzyme_14_Protein_Sequence:
>Estradiol 17betadehydrogenase 2
MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL
FSVSCFLMYT
YLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGP
GAEELRRTCSPRLSVLQMDIT
KPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGE
LLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKS
KGRLVNVSSMGGGAPMERLASYGSSKA
AVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLE
KDILDHLPAEVQEDYG
QDYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICL
AHYLP
IGIYDYFAKRHFGQDKPMPRALRMPNYKKKAT

# Metabolic_Enzyme_14_Number_of_Residues:
387

# Metabolic_Enzyme_14_Molecular_Weight:
42786

# Metabolic_Enzyme_14_Theoretical_pI:
8.62

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH

# Metabolic_Enzyme_14_Pathway:
map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_14_Reaction:
estradiol-17beta + NAD(P)+ = estrone + NAD(P)H + H+

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_14_Signals:
1-20

# Metabolic_Enzyme_14_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 1.1.1.62

# Metabolic_Enzyme_14_GenBank_ID_Protein:
306462

# Metabolic_Enzyme_14_SwissProt_ID:
DHB2_HUMAN (P37059)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
HSD17B2

# Metabolic_Enzyme_14_Geneatlas_id:
HSD17B2

# Metabolic_Enzyme_14_hgnc_id:
HGNC:5211

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Metabolic_Enzyme_14_Gene_Sequence:
>1164 bp

ATGAGCACTTTCTTCTCGGACACAGCATGGATCTGCCTGGCTGTCCCCACAGTACTATG
TGGGACAGTAT
TTTGCAAATACAAGAAGAGCTCAGGGCAGCTGTGGAGCTGGATGGTCT
GCCTGGCAGGCCTCTGTGCAGT
CTGCCTGCTCATCCTGTCCCCTTTTTGGGGCTTGATC
CTCTTCTCGGTGTCATGCTTCCTCATGTATACT
TACTTATCTGGCCAAGAATTGTTACC
TGTGGATCAGAAGGCAGTCCTGGTGACAGGTGGTGATTGCGGGC
TTGGCCATGCTTTGT
GCAAGTATCTGGATGAGCTGGGCTTCACGGTATTTGCCGGAGTTTTGAATGAAAA
TGGC
CCAGGAGCTGAGGAATTGCGAAGAACCTGCTCTCCGCGCCTCTCGGTGCTCCAAATGGAC
ATCACG
AAGCCAGTGCAGATAAAAGATGCTTACAGCAAGGTTGCAGCAATGCTGCAGGA
CAGAGGACTGTGGGCTG
TGATCAACAATGCTGGGGTGCTTGGCTTTCCAACTGATGGGG
AGCTTCTTCTTATGACTGACTACAAACA
ATGCATGGCCGTGAACTTCTTTGGAACTGTG
GAGGTCACAAAGACGTTTTTGCCTCTTCTTAGAAAATCC
AAAGGGAGGCTGGTGAATGT
CAGCAGCATGGGAGGAGGGGCCCCAATGGAAAGGCTGGCATCTTATGGCT
CATCAAAGG
CGGCTGTGACCATGTTCTCATCAGTTATGAGACTGGAGCTTTCCAAGTGGGGAATTAAAG
T
TGCTTCCATCCAACCTGGAGGCTTCCTAACAAATATCGCAGGCACCAGTGACAAGTGG
GAAAAGCTGGAG
AAGGACATTCTGGACCACCTCCCCGCTGAGGTACAGGAAGACTACGG
CCAGGACTACATCTTAGCACAGC
GGAATTTCCTCCTATTGATCAACTCGTTAGCCAGCA
AGGACTTCTCTCCGGTGCTGCGGGACATCCAGCA
TGCTATCTTGGCGAAGAGCCCTTTT
GCCTATTACACGCCAGGGAAAGGCGCTTACTTGTGGATCTGCCTT
GCTCACTATTTGCC
TATTGGCATATATGATTACTTTGCTAAAAGACATTTTGGCCAAGACAAGCCCATGC
CCA
GAGCTCTAAGAATGCCTAACTACAAGAAAAAGGCCACCTAG

# Metabolic_Enzyme_14_GenBank_ID_Gene:
L11708

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_14_Locus:
16q24.1-q24.2

# Metabolic_Enzyme_14_SNPs:
rs8191136; rs8191246; rs8191135; rs8191244; rs4445895; rs2966250; rs1364285; rs1364286; rs2042429; rs1017242; rs2966245; rs2955152; rs2955163; rs2966249; rs1364287; rs2955162; rs1017243; rs8046533; rs7196807; rs8060685; rs2966246; rs1424151; rs8191080; rs8049510; rs7200711; rs7203384; rs7205968; rs4318193; rs1559428; rs7201637; rs8191068; rs8191077; rs9319572; rs8049006; rs8049423; rs2911422; rs8191112; rs8050327; rs2966244; rs723012; rs4628962; rs4889456; rs8049750; rs8047385; rs7200696; rs2911420; rs7201121; rs2955159; rs8048090; rs4889453; rs8191089; rs9940004; rs8048018; rs7192075; rs11150437; rs8191167; rs11150436; rs8044837; rs8052451; rs7196087; rs8191156; rs3751860; rs7196609; rs6564961; rs8044382; rs8191159; rs11648233; rs11863907; rs8046220; rs8045494; rs2873459; rs2966241; rs16956274; rs7498701; rs723013; rs8191160; rs8056343; rs16956373; rs8191175; rs4888202; rs8191113; rs4889457; rs11150435; rs11642323; rs1559427; rs16956356; rs7184155; rs7184121; rs8191088; rs4398102; rs8191163; rs1816121; rs8191114; rs9929854; rs8191138; rs8191057; rs8059915; rs10514523; rs8191235; rs13339413; rs8191165; rs8191111; rs2966251; rs4480799; rs1559429; rs8191097; rs4497679; rs10514522; rs8191058; rs9788807; rs1981878; rs8191183; rs8191102; rs8191146; rs8191072; rs8061074; rs8191243; rs4468615; rs3111351; rs11865667; rs11865023; rs11150434; rs8191120; rs4243229; rs8191119; rs7186963; rs8191101; rs4453484; rs8054838; rs8191144; rs9889094; rs9939740; rs8191134; rs2955160; rs4589548; rs8191169; rs11860188; rs2966248; rs8191094; rs13337293; rs8191170; rs2317419; rs9934209; rs8191208; rs6564962; rs8191066; rs8191143; rs8191125; rs2955156; rs16956282; rs8191110; rs8191236; rs8191065; rs8191105; rs8191154; rs9934783; rs8191055; rs7203108; rs11867054; rs8191126; rs8191220; rs16956406; rs8191177; rs8191056; rs8191115; rs16956279; rs8191237; rs4889452; rs8191157; rs1981880; rs8191118; rs2955155; rs16956363; rs8191219; rs8191198; rs9925455; rs8191173; rs8191070; rs8191123; rs8191194; rs8191207; rs8191121; rs8191152; rs8191069; rs8191141; rs8191099; rs8191117; rs2955153; rs8191184; rs8191206; rs8191212; rs8191095; rs8191148; rs8191197; rs8191084; rs8191226; rs8062467; rs8191100; rs8191147; rs11645641; rs8191122; rs7499494; rs8191140; rs8191174; rs8191204; rs9931597; rs8191155; rs8191137; rs2911417; rs16956276; rs2911418; rs1981879; rs8191186; rs11647954; rs8191129; rs8191232; rs8191132; rs8191233; rs8191223; rs13331247; rs16956360; rs8191093; rs8191083; rs8191164; rs8191062; rs8191158; rs8191205; rs8191171; rs8191178; rs8191192; rs8191131; rs8191124; rs8191242; rs16956351; rs2955151; rs8191224; rs7205168; rs8191195; rs8191130; rs7203506; rs8182164; rs4258604; rs8191225; rs8191188; rs2873503; rs8191127; rs8191202; rs16956292; rs8191081; rs7189128; rs8191181; rs8191210; rs16956326; rs8191241; rs8191142; rs6564964; rs7206573; rs8191231; rs8191180; rs8191073; rs8191071; rs8191059; rs4587969; rs8191161; rs8191082; rs13337657; rs2955157; rs8191054; rs8191211; rs8061420; rs8191075; rs8055526; rs4889451; rs8061331; rs8054931; rs8191049; rs8191048; rs8191248; rs8191050; rs8045403; rs8191044; rs8191047; rs8191045; rs8191051; rs3841245; rs34731990; rs12926193; rs8191053; rs8191245; rs8191052; rs8191209; rs7195902; rs8191109; rs8047676; rs35542346; rs8191116; rs34663442; rs8191168; rs11316956; rs8191201; rs7185224; rs12935336; rs16956349; rs2911419; rs8191196; rs8191086; rs8191063; rs8191218; rs35477676; rs4595797; rs8191079; rs35929573; rs12934918; rs10714516; rs10609893; rs8191067; rs8191074; rs35094236; rs35553743; rs8191191; rs28415730; rs8191087; rs1559430; rs8191234; rs8191104; rs12921045; rs7359416; rs16956334; rs34787393; rs5818365; rs8191185; rs11336584; rs8060661; rs7201778; rs7200873; rs2042428; rs35106065; rs8191098; rs8191064; rs2966243; rs8191090; rs2955154; rs28720979; rs12930423; rs34014888; rs8191061; rs4602032; rs7359419; rs28458323; rs10655291; rs11447223; rs8191149; rs8191078; rs34076692; rs34972528; rs8191085; rs35003963; rs7359420; rs5818366; rs34304419; rs35200926; rs8191106; rs8191214; rs8191213; rs12934750; rs35421064; rs34511068; rs12933612; rs35272646; rs1034475; rs34184569; rs8191230; rs7185037; rs12149935; rs34364464; rs8051789; rs11354860; rs10565122; rs7195231; rs8191150; rs8191215; rs8044959; rs12930422; rs8191228; rs11865855; rs34353182; rs8191187; rs34165598; rs8191145; rs8191182; rs8191172; rs8191096; rs8191162; rs8191076; rs13330917; rs8191139; rs8191240; rs5818364; rs8191153; rs8191060; rs8191216; rs2113283; rs7189336; rs2955158; rs7359410; rs35072627; rs35417845; rs12103269; rs8191227; rs34860346; rs10565056; rs2911421; rs8191107; rs8057705; rs2966247; rs8191176; rs4447422; rs8191238; rs8059728; rs8191166; rs12918089; rs35162139; rs8191151; rs8191108; rs8191091; rs8191221; rs8191199; rs8191200; rs8191229; rs8191217; rs8191222; rs8191189; rs35078894; rs8191133; rs8191103; rs8191239; rs8191128; rs12600162; rs16956386; rs34530732; rs8063624; rs8191092; rs8191190; rs13330818; rs4293372; rs2955161; rs8191179; rs8191193; rs35439668; rs35457032; rs11428727; rs8191046; rs5818363; rs8191247; rs36081729; rs10595118; rs10514524; rs10514525; rs10514526; rs10514527; rs11150433; rs11150438; rs1119933; rs1157100; rs11643002; rs11649253; rs12919119; rs13333018; rs13333826; rs13380561; rs1364283; rs1364284; rs16956236; rs16956238; rs16956242; rs16956244; rs16956248; rs16956419; rs16956433; rs2317615; rs4262939; rs4274431; rs4291899; rs4378606; rs4635338; rs7188332; rs7190839; rs7198264; rs7202378; rs8044330; rs8046900; rs8055539; rs8060285; rs8060993; rs8063114; rs8064117; rs8191249; rs8191250; rs8191251; rs8191253; rs8191256; rs989018; rs989019; rs989020; rs9923501; rs9926000; rs9926211; rs9940683; rs996751; rs996752

# Metabolic_Enzyme_14_General_References:
8099587; 7546291

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5728

# Metabolic_Enzyme_15_Name:
UDP-glucuronosyltransferase 1-3 precursor

# Metabolic_Enzyme_15_Synonyms:
UDP- glucuronosyltransferase 1A3; UDPGT; UGT1*3; UGT1-03; UGT1.3; UGT- 1C; UGT1C

# Metabolic_Enzyme_15_Gene_Name:
UGT1A3

# Metabolic_Enzyme_15_Protein_Sequence:
>UDPglucuronosyltransferase 13 precursor
MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVV
LTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNM
SLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDL
DFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQ
REVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_15_Number_of_Residues:
534

# Metabolic_Enzyme_15_Molecular_Weight:
60339

# Metabolic_Enzyme_15_Theoretical_pI:
8.28

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_15_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_15_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_15_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_15_Signals:
1-28

# Metabolic_Enzyme_15_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_15_GenBank_ID_Protein:
340135

# Metabolic_Enzyme_15_SwissProt_ID:
UD13_HUMAN (P35503)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
UGT1A3

# Metabolic_Enzyme_15_Geneatlas_id:
UGT1A3

# Metabolic_Enzyme_15_hgnc_id:
HGNC:12535

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Microsome

# Metabolic_Enzyme_15_Gene_Sequence:
>867 bp
ATGGCCACAGGACTCCAGGTTCCCCTGCCGTGGCTGGCCACAGGACTGCTGCTTCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCATTGATGGCAGCCAC
TGGCTCAGCATGCGGGAGGTCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCAGTGGTC
CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAACTTTTTCACCCTGACAACCTAT
GCCATTTCGTGGACCCAGGATGAATTTGATCGCCATGTGCTGGGCCACACTCAACTGTAC
TTTGAAACAGAACATTTTCTGAAGAAATTTTTCAGAAGTATGGCAATGTTGAACAATATG
TCTTTGGTCTATCATAGGTCTTGTGTGGAGCTACTACATAATGAGGCCCTGATCAGGCAC
CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGCGCGGCAGTG
CTGGCTAAGTACCTGTCGATTCCTACTGTGTTTTTTTTGAGGAACATTCCATGTGATTTA
GACTTTAAGGGCACACAGTGTCCAAACCCTTCCTCCTATATTCCTAGATTACTAACAACC
AATTCAGACCACATGACATTCATGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACATTTGCCATGCTTTTTCTGCTCCTTATGCAAGCCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATATTCTCAGTCATGCATCTGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGACTACCCCAGGCCAATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACAGGAAGCCACTATCTCAG

# Metabolic_Enzyme_15_GenBank_ID_Gene:
M84127

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_15_Locus:
2q37

# Metabolic_Enzyme_15_SNPs:
Not Available

# Metabolic_Enzyme_15_General_References:
1339448; 11434514

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5730

# Metabolic_Enzyme_16_Name:
UDP-glucuronosyltransferase 1-10 precursor

# Metabolic_Enzyme_16_Synonyms:
UDPGT; UGT1*10; UGT1-10; UGT1.10; UGT-1J; UGT1J

# Metabolic_Enzyme_16_Gene_Name:
UGT1A10

# Metabolic_Enzyme_16_Protein_Sequence:
>UDPglucuronosyltransferase 110 precursor
MARAGWTSPVPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLF
FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEG
AQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_16_Number_of_Residues:
530

# Metabolic_Enzyme_16_Molecular_Weight:
59810

# Metabolic_Enzyme_16_Theoretical_pI:
7.31

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_16_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_16_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_16_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_16_Signals:
1-25

# Metabolic_Enzyme_16_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_16_GenBank_ID_Protein:
2039362

# Metabolic_Enzyme_16_SwissProt_ID:
UD110_HUMAN (Q9HAW8)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
UGT1A10

# Metabolic_Enzyme_16_Geneatlas_id:
UGT1A10

# Metabolic_Enzyme_16_hgnc_id:
HGNC:12531

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Microsome

# Metabolic_Enzyme_16_Gene_Sequence:
>1593 bp
ATGGCTCCGCGCAGGGTGGACCAGCCCCGTTCCTTTATGTGTGTGTCTACTGCTGACCTG
TGGCTTTGCGAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGTCACTGGTTCGCC
ATGCAGTCGGTGGTGGAGAAACTTATCCTCAGGGGGCATGAGGTGGTTGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGAAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCG
TACACTCTGGAAGATCAGAACCGGGAATTCATGGTTTTCGCCCATGCTCAATGGAAAGCA
CAGGCACAAAGTATATTTTCTCTATTAATGAGTTCATCCAGTGGTTTTCTTGACTTATTT
TTTTCGCATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCAGTGTTTCTGGATCCTTTTGATACCTGTGGCTTAATTGTTGCTAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCACCAGGGGAATATTTTGCCGCCATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAATGATCTCTTAGGGTTCTCAGATGCC
ATGACTTTCAAGGAGAGAGTATGGAACCACATCGTGCACTTGGAGGACCATTTATTTTGC
CAGTATCTTTTAAGAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGTCACACATCAATTTGGTTGTTGCGAACGGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAACATGATCTTCATTGGTGGTATCAACTGTCATCAGGGA
AAGCCATTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
U89508

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_16_Locus:
2q37

# Metabolic_Enzyme_16_SNPs:
Not Available

# Metabolic_Enzyme_16_General_References:
9271343; 11434514

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5720

# Metabolic_Enzyme_17_Name:
UDP-glucuronosyltransferase 2B10 precursor

# Metabolic_Enzyme_17_Synonyms:
UDPGT

# Metabolic_Enzyme_17_Gene_Name:
UGT2B10

# Metabolic_Enzyme_17_Protein_Sequence:
>UDPglucuronosyltransferase 2B10 precursor
MALKWTTVLLIQLSFYFSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSAS
ILFDPNDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEILWAIND
IIRNFCKDVVSNKKLMKKLQESRFDIVFADAYLPCGELLAELFNIPFVYSHSFSPGYSFE
RHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWFQIFNMKKWDQFYSEVLG
RPTTLSETMRKADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGE
NGVVVFSLGSMVSNMTEERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQND
LLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMS
STDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAH
NLTWFQYHSLDVIGFLLACVATVLFIITKCCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_17_Number_of_Residues:
528

# Metabolic_Enzyme_17_Molecular_Weight:
60775

# Metabolic_Enzyme_17_Theoretical_pI:
9.40

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_17_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_17_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_17_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_17_Signals:
1-23

# Metabolic_Enzyme_17_Transmembrane_Regions:
492-512

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_17_GenBank_ID_Protein:
516150

# Metabolic_Enzyme_17_SwissProt_ID:
UDB10_HUMAN (P36537)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
UGT2B10

# Metabolic_Enzyme_17_Geneatlas_id:
UGT2B10

# Metabolic_Enzyme_17_hgnc_id:
HGNC:12544

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Microsome

# Metabolic_Enzyme_17_Gene_Sequence:
>1587 bp
ATGGCTCTGAAATGGACTACAGTTCTGCTGATACAACTCAGTTTTTACTTTAGCTCTGGG
AGTTGTGGAAAGGTGCTGGTATGGGCCGCAGAATACAGCCTTTGGATGAATATGAAGACA
ATCCTGAAAGAACTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCTTCC
ATTCTTTTTGATCCCAACGACTCATCCACTCTTAAACTTGAAGTTTATCCTACATCTTTA
ACTAAAACTGAATTTGAGAATATCATCATGCAATTGGTTAAGAGATTGTCAGAAATTCAA
AAAGATACATTTTGGTTACCTTTTTCACAAGAACAAGAAATCCTGTGGGCAATTAATGAC
ATAATTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAACTTATGAAAAAACTACAA
GAGTCAAGATTTGACATCGTTTTTGCAGATGCTTATTTACCCTGTGGTGAGCTGCTGGCT
GAGCTATTTAACATACCCTTTGTGTACAGTCACAGCTTCAGTCCTGGCTACTCATTTGAA
AGGCACAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAAAATTA
AGTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGCTCTATGTGCTTTATTTTGAC
TTTTGGTTCCAAATATTTAATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTAGGA
AGACCCACTACATTATCTGAGACAATGAGGAAAGCTGACATATGGCTTATGCGAAACTCC
TGGAATTTTAAATTTCCTCATCCATTCTTACCAAATGTTGATTTTGTTGGAGGACTCCAC
TGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAGTTTGTACAGAGCTCTGGAGAA
AATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGGGCC
AACGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTTTGGAGATTTGATGGG
AATAAACCAGATGCCTTAGGTCTCAATACTCGACTGTACAAGTGGATACCCCAGAATGAC
CTTCTAGGTCATCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATCTAT
GAGGCAATCTACCATGGGATCCCTATGGTGGGCATTCCATTGTTTTTTGATCAACCTGAT
AATATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGAGTGGACTTCAACACAATGTCG
AGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTCATATAAAGAGAAT
ATTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCAGTC
TTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCCAAACATCTTCGAGTTGCAGCCCAC
AACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGCTTGTGTG
GCAACCGTGCTATTTATCATCACAAAGTGTTGTCTGTTTTGTTTCTGGAAGTTTGCTAGA
AAAGGAAAGAAGGGAAAAAGGGATTAG

# Metabolic_Enzyme_17_GenBank_ID_Gene:
X63359

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_17_Locus:
4q13.2

# Metabolic_Enzyme_17_SNPs:
rs3208727; rs17146903; rs17146904; rs835313; rs835316; rs835309; rs861340; rs844342; rs1841042; rs294778; rs835311; rs2670431; rs294777; rs835317; rs7676529; rs835310; rs11726322; rs11249509; rs1968764; rs7676146; rs1849533; rs17146894; rs835314; rs294772; rs9917967; rs2054221; rs3792628; rs1849534; rs1913316; rs7657958; rs1913315; rs2926036; rs835312; rs1913317; rs4694343; rs835319; rs7673996; rs2670430; rs835315; rs4694344; rs1913318; rs7670334; rs1913320; rs11940320; rs294776; rs4694358; rs294775; rs1976666; rs4095564; rs9917968; rs2942857; rs4116824; rs3215212; rs28563143; rs1902931; rs13111730; rs12506094; rs1979281; rs11347207; rs34334121; rs12511664; rs5859144; rs5859145; rs13141448; rs4116823; rs28377589; rs35887929; rs36003814; rs34999460; rs7678703; rs9917930; rs35390620; rs1902932; rs7674011; rs6839369; rs10007687; rs4095563; rs5859146; rs1902930; rs13148664; rs33938096; rs13110924; rs5859147; rs7685333; rs28586884; rs10428371; rs294771; rs13132114; rs6839806; rs34291505; rs13131461; rs13132118; rs13114078; rs4116825; rs13111722; rs835318; rs17146905; rs34183546; rs35690388; rs11725502; rs35525464; rs11729424; rs11737566; rs11737644; rs1379809; rs1458232; rs1458233; rs294765; rs294770; rs4450999; rs4694340; rs6816491; rs6836993; rs6843220

# Metabolic_Enzyme_17_General_References:
8333863

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
6128

# Metabolic_Enzyme_18_Name:
Estradiol 17-beta-dehydrogenase 1

# Metabolic_Enzyme_18_Synonyms:
17-beta- hydroxysteroid dehydrogenase type 1; 17-beta-HSD 1; Placental 17- beta-hydroxysteroid dehydrogenase; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH

# Metabolic_Enzyme_18_Gene_Name:
HSD17B1

# Metabolic_Enzyme_18_Protein_Sequence:
>Estradiol 17betadehydrogenase 1
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL
ETLQLDVRDS
KSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGT
VRMLQAFLPDMKRRGSGRVLV
TGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG
VHLSLIECGPVHTAFMEKVLGSPEEVLDRTDI
HTFHRFYQYLAHSKQVFREAAQNPEEV
AEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAM
HREVFGDVPAKAEAGA
EAGGGAGPGAEDEAGRSAVGDPELGDPPAAPQ

# Metabolic_Enzyme_18_Number_of_Residues:
328

# Metabolic_Enzyme_18_Molecular_Weight:
34980

# Metabolic_Enzyme_18_Theoretical_pI:
5.42

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  estradiol 17-beta-dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
Process:  estrogen biosynthesis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_18_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_18_Specific_Function:
Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH

# Metabolic_Enzyme_18_Pathway:
map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_18_Reaction:
estradiol-17beta + NAD(P)+ = estrone + NAD(P)H + H+

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_18_Signals:
1-30

# Metabolic_Enzyme_18_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 1.1.1.62

# Metabolic_Enzyme_18_GenBank_ID_Protein:
23365

# Metabolic_Enzyme_18_SwissProt_ID:
DHB1_HUMAN (P14061)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
HSD17B1

# Metabolic_Enzyme_18_Geneatlas_id:
HSD17B1

# Metabolic_Enzyme_18_hgnc_id:
HGNC:5210

# Metabolic_Enzyme_18_PDB_ID:
1QYX

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_18_Gene_Sequence:
>987 bp

ATGGCCCGCACCGTGGTGCTCATCACCGGCTGTTCCTCGGGCATCGGCCTGCACTTGGC
CGTACGTCTGG
CTTCAGATCCATCCCAGAGCTTCAAAGTGTATGCCACGTTGAGGGACC
TGAAAACACAGGGCCGGCTGTG
GGAGGCGGCCCGGGCCCTGGCATGCCCTCCGGGATCC
CTGGAGACGTTGCAGCTGGACGTAAGGGACTCA
AAATCCGTGGCCGCTGCCCGGGAACG
CGTGACTGAGGGCCGCGTGGACGTGCTGGTGTGTAACGCAGGCC
TGGGCCTGCTGGGGC
CGCTGGAGGCGCTGGGGGAGGACGCCGTGGCCTCTGTGCTGGACGTGAATGTAGT
AGGG
ACTGTGCGGATGCTGCAGGCCTTCCTGCCAGACATGAAGAGGCGCGGTTCGGGACGCGTG
TTGGTG
ACCGGGAGCGTGGGAGGATTGATGGGGCTGCCTTTCAATGACGTTTATTGCGC
CAGCAAGTTCGCGCTCG
AAGGCTTATGCGAGAGTCTGGCGGTTCTGCTGCTGCCCTTTG
GGGTCCACTTGAGCCTGATCGAGTGCGG
CCCAGTGCACACCGCCTTCATGGAGAAGGTG
TTGGGCAGCCCAGAGGAGGTGCTGGACCGCACGGACATC
CACACCTTCCACCGCTTCTA
CCAATACCTCGCCCACAGCAAGCAAGTCTTTCGCGAGGCGGCGCAGAACC
CTGAGGAGG
TGGCGGAGGTCTTCCTCACCGCTTTGCGCGCCCCGAAGCCGACCCTGCGCTACTTCACCA
C
CGAGCGCTTCCTGCCCCTGCTGCGGATGCGCCTGGACGACCCCAGCGGCTCCAACTAC
GTCACCGCCATG
CACCGGGAAGTGTTCGGCGACGTTCCGGCAAAGGCCGAGGCTGGGGC
CGAGGCTGGGGGCGGGGCCGGGC
CTGGGGCAGAGGACGAGGCCGGGCGCAGTGCGGTGG
GGGACCCTGAGCTCGGCGATCCTCCGGCCGCCCC
GCAGTAA

# Metabolic_Enzyme_18_GenBank_ID_Gene:
X13440

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_18_Locus:
17q11-q21

# Metabolic_Enzyme_18_SNPs:
rs605059; rs12945667; rs2830; rs2229233; rs2676531; rs597255; rs610166; rs2676530; rs610177; rs676387; rs592389; rs670452; rs470842; rs9915824; rs470885; rs28490403; rs1051381; rs28722471; rs2676532; rs6413434; rs35099842; rs10153; rs675733; rs2854974; rs470904; rs2855481; rs2855482; rs35545131; rs1048170; rs1048178; rs12602084; rs16967862; rs2301132; rs2854977; rs2854978; rs2855484; rs3177667; rs3752386; rs598126; rs607740; rs607795; rs615942; rs621141; rs629861; rs666039; rs668799; rs7219522

# Metabolic_Enzyme_18_General_References:
2846351; 2779584; 2330005; 2197970; 1327779; 5045524; 4719204; 3955020; 6578212; 2547159; 7663947; 8805577; 9525918; 10625652; 8389226

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5726

# Metabolic_Enzyme_19_Name:
UDP-glucuronosyltransferase 1-9 precursor

# Metabolic_Enzyme_19_Synonyms:
UDP- glucuronosyltransferase 1A9; UDPGT; UGT1*9; UGT1-9; UGT1.9; UGT- 1I; UGT1I; lugP4

# Metabolic_Enzyme_19_Gene_Name:
UGT1A9

# Metabolic_Enzyme_19_Protein_Sequence:
>UDPglucuronosyltransferase 19 precursor
MACTGWTSPLPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMRSVVEKLILRGHEVVVVMP
EVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLF
FSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNCGLIVAKYFSLPSVVFARGILCHYLEEG
AQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLLCHRFFKNALEIASEILQTPVT
EYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_19_Number_of_Residues:
530

# Metabolic_Enzyme_19_Molecular_Weight:
59942

# Metabolic_Enzyme_19_Theoretical_pI:
7.96

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_19_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols

# Metabolic_Enzyme_19_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_19_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_19_Signals:
1-25

# Metabolic_Enzyme_19_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_19_GenBank_ID_Protein:
7690346

# Metabolic_Enzyme_19_SwissProt_ID:
UD19_HUMAN (O60656)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
UGT1A9

# Metabolic_Enzyme_19_Geneatlas_id:
UGT1A9

# Metabolic_Enzyme_19_hgnc_id:
HGNC:12541

# Metabolic_Enzyme_19_PDB_ID:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Microsome

# Metabolic_Enzyme_19_Gene_Sequence:
>1593 bp
ATGGCTTGCACAGGGTGGACCAGCCCCCTTCCTCTATGTGTGTGTCTGCTGCTGACCTGT
GGCTTTGCCGAGGCAGGGAAGCTAGTGGTAGTGCCCATGGATGGGAGCCACTGGTTCACC
ATGAGGTCGGTGGTGGAGAAACTCATTCTCAGGGGGCATGAGGTGGTTGTAGTCAGTGCC
AGAGGTGAGTTGGCAACTGGGAAGATCAATGAATTGCACAGTGAAGACTTATTCAACTTC
ATATACCTGGAGGATCTGGACCGGGAGTTCAAGGCTTTTGCCCATGCTCAATGGAAAGCA
CAAGTACGAAGTATATATTCTCTATTAATGGGTTCATACAATGACATTTTTGACTTATTT
TTTTCAAATTGCAGGAGTTTGTTTAAAGACAAAAAATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCAGTGTTTCTCGATCCTTTTGATAACTGTGGCTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCCGTGGTCTTCGCCAGGGGAATACTTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGAATTCTCTTAGGGTTCTCAGATGAC
ATGACTTTCAAGGAGAGAGTACGGAACCACATCATGCACTTGGAGGAACATTTATTATGC
CACCGTTTTTTCAAAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACACCTGTTACG
GAGTATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACGGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAACATGATCTTCATTGGTGGTATCAACTGCCATGAGAGG
AAAGCGTTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GGTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATGC
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCAGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCATGAATGTTCTGGAAATGACTTCTGAAGAATTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTTATGAGGCACAAGGGCGCGACACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGCCGTGCTGACAGTGGCC
TTCATCACCTGTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
S55985

# Metabolic_Enzyme_19_Chromosome_Location:
Not Available

# Metabolic_Enzyme_19_Locus:
Not Available

# Metabolic_Enzyme_19_SNPs:
Not Available

# Metabolic_Enzyme_19_General_References:
1910331; 11434514

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
5691

# Metabolic_Enzyme_20_Name:
Estradiol 17-beta-dehydrogenase 8

# Metabolic_Enzyme_20_Synonyms:
17-beta-HSD 8; 17- beta-hydroxysteroid dehydrogenase 8; Protein Ke6; Ke-6

# Metabolic_Enzyme_20_Gene_Name:
HSD17B8

# Metabolic_Enzyme_20_Protein_Sequence:
>Estradiol 17betadehydrogenase 8
MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGS
KEGPPRGNHA
AFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDD
WDKVIAVNLKGTFLVTQAAAQ
ALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIG
LTQTAARELGRHGIRCNSVLPGFIATPMTQKV
PQKVVDKITEMIPMGHLGDPEDVADVV
AFLASEDSGYITGTSVEVTGGLFM

# Metabolic_Enzyme_20_Number_of_Residues:
261

# Metabolic_Enzyme_20_Molecular_Weight:
26974

# Metabolic_Enzyme_20_Theoretical_pI:
6.50

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_20_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_20_Specific_Function:
Uses estradiol as its preferred substrate

# Metabolic_Enzyme_20_Pathway:
map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_20_Reaction:
estradiol-17beta + NAD(P)+ = estrone + NAD(P)H + H+

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_20_Signals:
None

# Metabolic_Enzyme_20_Transmembrane_Regions:
None

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 1.1.1.62

# Metabolic_Enzyme_20_GenBank_ID_Protein:
30583317

# Metabolic_Enzyme_20_SwissProt_ID:
DHB8_HUMAN (Q92506)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
HSD17B8

# Metabolic_Enzyme_20_Geneatlas_id:
HSD17B8

# Metabolic_Enzyme_20_hgnc_id:
HGNC:3554

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Not Available

# Metabolic_Enzyme_20_Gene_Sequence:
>786 bp

ATGGCGTCTCAGCTCCAGAACCGACTCCGCTCCGCACTGGCCTTGGTCACAGGTGCGGG
GAGCGGCATCG
GCCGAGCGGTCAGTGTACGCCTGGCCGGAGAGGGGGCCACCGTAGCTG
CCTGCGACCTGGACCGGGCAGC
GGCACAGGAGACGGTGCGGCTGCTGGGCGGGCCAGGG
AGCAAGGAGGGGCCGCCCCGAGGGAACCATGCT
GCCTTCCAGGCTGACGTGTCTGAGGC
CAGGGCCGCCAGGTGCCTGCTGGAACAAGTGCAGGCCTGCTTTT
CTCGCCCACCATCTG
TCGTTGTGTCCTGTGCGGGCATCACCCAGGATGAGTTTCTGCTGCACATGTCTGA
GGAT
GACTGGGACAAAGTCATAGCTGTCAACCTCAAGGGCACCTTCCTAGTCACTCAGGCTGCA
GCACAA
GCCCTGGTGTCCAATGGTTGTCGTGGTTCCATCATCAACATCAGTAGCATCGT
AGGAAAGGTGGGGAACG
TGGGGCAGACAAACTATGCAGCATCCAAGGCTGGAGTGATTG
GGCTGACCCAGACCGCAGCCCGGGAGCT
TGGACGACATGGGATCCGCTGTAACTCTGTC
CTCCCAGGGTTCATTGCAACACCCATGACACAGAAAGTG
CCACAGAAAGTGGTGGACAA
GATTACTGAAATGATCCCGATGGGACACTTGGGGGACCCTGAGGATGTGG
CAGATGTGG
TCGCATTCTTGGCATCTGAAGATAGTGGATACATCACAGGGACCTCAGTGGAAGTCACTG
G
AGGTCTTTTCATGTAG

# Metabolic_Enzyme_20_GenBank_ID_Gene:
BT007239

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_20_Locus:
6p21.3

# Metabolic_Enzyme_20_SNPs:
Not Available

# Metabolic_Enzyme_20_General_References:
14574404; 8812499

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
6129

# Metabolic_Enzyme_21_Name:
3-keto-steroid reductase

# Metabolic_Enzyme_21_Synonyms:
Estradiol 17-beta- dehydrogenase 7; 17-beta-HSD 7; 17-beta-hydroxysteroid dehydrogenase 7

# Metabolic_Enzyme_21_Gene_Name:
HSD17B7

# Metabolic_Enzyme_21_Protein_Sequence:
>3ketosteroid reductase
MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIV
QVDVSNLQSV
FRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFST
AEGLLTQGDKITADGLQEVFE
TNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSN
FSLEDFQHSKGKEPYSSSKYATDLLSVALNRN
FNQQGLYSNVACPGTALTNLTYGILPP
FIWTLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLN
PLIKYLSATTGFGRNY
IMTQKMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL

# Metabolic_Enzyme_21_Number_of_Residues:
341

# Metabolic_Enzyme_21_Molecular_Weight:
38207

# Metabolic_Enzyme_21_Theoretical_pI:
8.21

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_21_Specific_Function:
Responsible for the reduction of the keto group on the C-3 of sterols

# Metabolic_Enzyme_21_Pathway:
map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_21_Reaction:
4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP+ = 4alpha-methyl-5alpha-cholest-7-en-3-one + NADPH + H+

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_21_Signals:
1-19

# Metabolic_Enzyme_21_Transmembrane_Regions:
230-250

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 1.1.1.270;EC 1.1.1.62

# Metabolic_Enzyme_21_GenBank_ID_Protein:
6721095

# Metabolic_Enzyme_21_SwissProt_ID:
DHB7_HUMAN (P56937)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
HSD17B7

# Metabolic_Enzyme_21_Geneatlas_id:
HSD17B7

# Metabolic_Enzyme_21_hgnc_id:
HGNC:5215

# Metabolic_Enzyme_21_PDB_ID:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Membrane; single-pass membrane protein

# Metabolic_Enzyme_21_Gene_Sequence:
>1026 bp

ATGCGAAAGGTGGTTTTGATCACCGGGGCTAGCAGTGGCATTGGCCTGGCCCTCTGCAA
GCGGCTGCTGG
CGGAAGATGATGAGCTTCATCTGTGTTTGGCGTGCAGGAACATGAGCA
AGGCAGAAGCTGTCTGTGCTGC
TCTGCTGGCCTCTCACCCCACTGCTGAGGTCACCATT
GTCCAGGTGGATGTCAGCAACCTGCAGTCGGTC
TTCCGGGCCTCCAAGGAACTTAAGCA
AAGGTTTCAGAGATTAGACTGTATATATCTAAATGCTGGGATCA
TGCCTAATCCACAAC
TAAATATCAAAGCACTTTTCTTTGGCCTCTTTTCAAGAAAAGTGATTCATATGTT
CTCC
ACAGCTGAAGGCCTGCTGACCCAGGGTGATAAGATCACTGCTGATGGACTTCAGGAGGTG
TTTGAG
ACCAATGTCTTTGGCCATTTTATCCTGATTCGGGAACTGGAGCCTCTCCTCTG
TCACAGTGACAATCCAT
CTCAGCTCATCTGGACATCATCTCGCAGTGCAAGGAAATCTA
ATTTCAGCCTCGAGGACTTCCAGCACAG
CAAAGGCAAGGAACCCTACAGCTCTTCCAAA
TATGCCACTGACCTTTTGAGTGTGGCTTTGAACAGGAAC
TTCAACCAGCAGGGTCTCTA
TTCCAATGTGGCCTGTCCAGGTACAGCATTGACCAATTTGACATATGGAA
TTCTGCCTC
CGTTTATATGGACGCTGTTGATGCCGGCAATATTGCTACTTCGCTTTTTTGCAAATGCAT
T
CACTTTGACACCATATAATGGAACAGAAGCTCTGGTATGGCTTTTCCACCAAAAGCCT
GAATCTCTCAAT
CCTCTGATCAAATATCTGAGTGCCACCACTGGCTTTGGAAGAAATTA
TATTATGACCCAGAAGATGGACC
TAGATGAAGACACTGCTGAAAAATTTTATCAAAAGT
TACTGGAACTGGAAAAGCACATTAGGGTCACTAT
TCAAAAAACAGATAATCAGGCCAGG
CTCAGTGGCTCATGCCTATAA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
AF098786

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_21_Locus:
1q23

# Metabolic_Enzyme_21_SNPs:
rs1704754; rs1780010; rs1780019; rs2805053; rs1039874; rs10917598; rs4656381; rs2997871; rs1964714; rs1704753; rs2996587; rs1780012; rs1704752; rs1892125; rs2997870; rs2491094; rs2457597; rs2805056; rs9786956; rs12402864; rs11589262; rs10917597; rs2684881; rs9663079; rs2457593; rs9427412; rs1780018; rs7529094; rs2262154; rs11581847; rs7530544; rs3215683; rs1704760; rs2684877; rs7538367; rs2998105; rs11577831; rs9661994; rs2490798; rs1780011; rs1704755; rs2983957; rs2457601; rs2684875; rs2257864; rs2998104; rs2257578; rs2947613; rs12563263; rs2457624; rs12118590; rs1137574; rs2805052; rs1137576; rs1060464; rs1060466; rs1137575; rs2996593; rs2997363; rs2257867; rs4038285; rs2803853; rs41271993; rs2803875; rs2457620; rs28407183; rs2997636; rs28496676; rs2947612; rs2457623; rs2257753; rs2997868; rs4038282; rs12061476; rs4146687; rs1780017; rs28658433; rs2257574; rs2457594; rs2258232; rs12027467; rs2665498; rs2997637; rs35444310; rs2491089; rs2490878; rs34036280; rs35058037; rs4038266; rs2997633; rs12026208; rs2457588; rs2461259; rs2457622; rs2997366; rs34321369; rs28786082; rs4038286; rs2684884; rs2257752; rs4038263; rs2261522; rs28838384; rs4657230; rs2997638; rs2490873; rs28836851; rs2805055; rs2997360; rs2803882; rs4038268; rs2997866; rs28757377; rs35057012; rs11576487; rs2941411; rs4038267; rs2457587; rs2258219; rs2490877; rs11581908; rs2457621; rs2490874; rs34894082; rs12067455; rs2457595; rs2490797; rs4387160; rs2997365; rs4146688; rs7527982; rs35961178; rs34770807; rs2264620; rs2997865; rs2805054; rs4038264; rs2461258; rs2457596; rs2997361; rs2257594; rs2490880; rs2997634; rs11590943; rs2457598; rs1780013; rs12041044; rs2258222; rs1704751; rs11587814; rs34522457; rs2490876; rs2490875; rs2257597; rs4038284; rs2457619; rs2457589; rs2461257; rs2996594; rs2261528; rs2997635; rs2257866; rs4095366; rs2997867; rs28837117; rs4038265; rs4084040; rs2258297; rs2490879; rs28494776; rs2257588; rs6670180; rs2997872; rs2997869; rs2457615; rs2997364; rs2457603; rs2457607; rs2997632; rs2457600; rs2457604; rs2457608; rs2457609; rs2457602; rs1626296; rs2457599; rs2805051; rs2457605; rs2457606; rs2491090; rs12085483; rs12736939; rs1622198; rs1780000; rs2457633; rs2457635; rs2457636; rs2803872

# Metabolic_Enzyme_21_General_References:
10544267; 12975309; 12829805

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
5732

# Metabolic_Enzyme_22_Name:
UDP-glucuronosyltransferase 1-6 precursor

# Metabolic_Enzyme_22_Synonyms:
UDP- glucuronosyltransferase 1A6; UDPGT; UGT1*6; UGT1-06; UGT1.6; UGT- 1F; UGT1F; Phenol-metabolizing UDP-glucuronosyltransferase

# Metabolic_Enzyme_22_Gene_Name:
UGT1A6

# Metabolic_Enzyme_22_Protein_Sequence:
>UDPglucuronosyltransferase 16 precursor
MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVV
PEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIG
LYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEH
TFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRD
VDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHG
IVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLL
GHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSE
DLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDL
TWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_22_Number_of_Residues:
532

# Metabolic_Enzyme_22_Molecular_Weight:
60751

# Metabolic_Enzyme_22_Theoretical_pI:
8.55

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_22_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols

# Metabolic_Enzyme_22_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_22_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_22_Signals:
1-26

# Metabolic_Enzyme_22_Transmembrane_Regions:
490-506

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_22_GenBank_ID_Protein:
340141

# Metabolic_Enzyme_22_SwissProt_ID:
UD16_HUMAN (P19224)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
UGT1A6

# Metabolic_Enzyme_22_Geneatlas_id:
UGT1A6

# Metabolic_Enzyme_22_hgnc_id:
HGNC:12538

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Microsome

# Metabolic_Enzyme_22_Gene_Sequence:
>861 bp
ATGGCCTGCCTCCTTCGCTCATTTCAGAGAATTTCTGCAGGGGTTTTCTTCTTAGCACTT
TGGGGCATGGTTGTAGGTGACAAGCTGCTGGTGGTCCCTCAGGACGGAAGCCACTGGCTT
AGTATGAAGGATATAGTTGAGGTTCTCAGTGACCGGGGTCATGAGATTGTAGTGGTGGTG
CCTGAAGTTAATTTGCTTTTGAAAGAATCCAAATACTACACAAGAAAAATCTATCCAGTG
CCGTATGACCAAGAAGAGCTGAAGAACCGTTACCAATCATTTGGAAACAATCACTTTGCT
GAGCGATCATTCCTAACTGCTCCTCAGACAGAGTACAGGAATAACATGATTGTTATTGGC
CTGTACTTCATCAACTGCCAGAGCCTCCTGCAGGACAGGGACACCCTGAACTTCTTTAAG
GAGAGCAAGTTTGATGCTCTTTTCACAGACCCAGCCTTACCCTGTGGGGTGATCCTGGCT
GAGTATTTGGGCCTACCATCTGTGTACCTCTTCAGGGGTTTTCCGTGTTCCCTGGAGCAT
ACATTCAGCAGAAGCCCAGACCCTGTGTCCTACATTCCCAGGTGCTACACAAAGTTTTCA
GACCACATGACTTTTTCCCAACGAGTGGCCAACTTCCTTGTTAATTTGTTGGAGCCCTAT
CTATTTTATTGTCTGTTTTCAAAGTATGAAGAACTCGCATCAGCTGTCCTCAAGAGAGAT
GTGGATATAATCACCTTATATCAGAAGGTCTCTGTTTGGCTGTTAAGATATGACTTTGTG
CTTGAATATCCTAGGCCGGTCATGCCCAACATGGTCTTCATTGGAGGTATCAACTGTAAG
AAGAGGAAAGACTTGTCTCAG

# Metabolic_Enzyme_22_GenBank_ID_Gene:
M84130

# Metabolic_Enzyme_22_Chromosome_Location:
Not Available

# Metabolic_Enzyme_22_Locus:
Not Available

# Metabolic_Enzyme_22_SNPs:
Not Available

# Metabolic_Enzyme_22_General_References:
1339448; 3141926; 11434514; 9466822; 9429234

# Metabolic_Enzyme_22_References:
Not Available

# Metabolic_Enzyme_23_ID:
5722

# Metabolic_Enzyme_23_Name:
UDP-glucuronosyltransferase 2B15 precursor

# Metabolic_Enzyme_23_Synonyms:
UDPGT; UDPGTh-3; HLUG4

# Metabolic_Enzyme_23_Gene_Name:
UGT2B15

# Metabolic_Enzyme_23_Protein_Sequence:
>UDPglucuronosyltransferase 2B15 precursor
MSLKWTSVFLLIQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVTVLTSSA
STLVNASKSSAIKLEVYPTSLTKNDLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEY
YDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGELLAELFNIPFLYSLRFSVGYT
FEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYSEV
LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
MSSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVA
AHNLTWIQYHSLDVIAFLLACVATVIFIITKFCLFCFRKLAKKGKKKKRD

# Metabolic_Enzyme_23_Number_of_Residues:
530

# Metabolic_Enzyme_23_Molecular_Weight:
60989

# Metabolic_Enzyme_23_Theoretical_pI:
9.04

# Metabolic_Enzyme_23_GO_Classification:
Not Available

# Metabolic_Enzyme_23_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_23_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens

# Metabolic_Enzyme_23_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_23_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_23_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_23_Signals:
1-23

# Metabolic_Enzyme_23_Transmembrane_Regions:
495-515

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_23_GenBank_ID_Protein:
23955933

# Metabolic_Enzyme_23_SwissProt_ID:
UDB15_HUMAN (P54855)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
UGT2B15

# Metabolic_Enzyme_23_Geneatlas_id:
UGT2B15

# Metabolic_Enzyme_23_hgnc_id:
HGNC:12546

# Metabolic_Enzyme_23_PDB_ID:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Microsome

# Metabolic_Enzyme_23_Gene_Sequence:
>1593 bp
ATGTCTCTGAAATGGACGTCAGTCTTTCTGCTGATACAGCTCAGTTGTTACTTTAGCTCT
GGAAGCTGTGGAAAGGTGCTAGTGTGGCCCACAGAATACAGCCATTGGATAAATATGAAG
ACAATCCTGGAAGAGCTTGTTCAGAGGGGTCATGAGGTGACTGTGTTGACATCTTCGGCT
TCTACTCTTGTCAATGCCAGTAAATCATCTGCTATTAAATTAGAAGTTTATCCTACATCT
TTAACTAAAAATGATTTGGAAGATTCTCTTCTGAAAATTCTCGATAGATGGATATATGGT
GTTTCAAAAAATACATTTTGGTCATATTTTTCACAATTACAAGAATTGTGTTGGGAATAT
TATGACTACAGTAACAAGCTCTGTAAAGATGCAGTTTTGAATAAGAAACTTATGATGAAA
CTACAAGAGTCAAAGTTTGATGTCATTCTGGCAGATGCCCTTAATCCCTGTGGTGAGCTA
CTGGCTGAACTATTTAACATACCCTTTCTGTACAGTCTTCGATTCTCTGTTGGCTACACA
TTTGAGAAGAATGGTGGAGGATTTCTGTTCCCTCCTTCCTATGTACCTGTTGTTATGTCA
GAATTAAGTGATCAAATGATTTTCATGGAGAGGATAAAAAATATGATACATATGCTTTAT
TTTGACTTTTGGTTTCAAATTTATGATCTGAAGAAGTGGGACCAGTTTTATAGTGAAGTT
CTAGGAAGACCCACTACATTATTTGAGACAATGGGGAAAGCTGAAATGTGGCTCATTCGA
ACCTATTGGGATTTTGAATTTCCTCGCCCATTCTTACCAAATGTTGATTTTGTTGGAGGA
CTTCACTGTAAACCAGCCAAACCCCTGCCTAAGGAAATGGAAGAGTTTGTGCAGAGCTCT
GGAGAAAATGGTATTGTGGTGTTTTCTCTGGGGTCGATGATCAGTAACATGTCAGAAGAA
AGTGCCAACATGATTGCATCAGCCCTTGCCCAGATCCCACAAAAGGTTCTATGGAGATTT
GATGGCAAGAAGCCAAATACTTTAGGTTCCAATACTCGACTGTACAAGTGGTTACCCCAG
AATGACCTTCTTGGTCATCCCAAAACCAAAGCTTTTATAACTCATGGTGGAACCAATGGC
ATCTATGAGGCGATCTACCATGGGATCCCTATGGTGGGCATTCCCTTGTTTGCGGATCAA
CATGATAACATTGCTCACATGAAAGCCAAGGGAGCAGCCCTCAGTGTGGACATCAGGACC
ATGTCAAGTAGAGATTTGCTCAATGCATTGAAGTCAGTCATTAATGACCCTGTCTATAAA
GAGAATGTCATGAAATTATCAAGAATTCATCATGACCAACCAATGAAGCCCCTGGATCGA
GCAGTCTTCTGGATTGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTTCGAGTCGCA
GCTCACAACCTCACCTGGATCCAGTACCACTCTTTGGATGTGATAGCATTCCTGCTGGCC
TGCGTGGCAACTGTGATATTTATCATCACAAAATTTTGCCTGTTTTGTTTCCGAAAGCTT
GCCAAAACAGGAAAGAAGAAGAAAAGAGATTAG

# Metabolic_Enzyme_23_GenBank_ID_Gene:
AF548389

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_23_Locus:
4q13

# Metabolic_Enzyme_23_SNPs:
rs6825560; rs988562; rs1120265; rs1960773; rs7686914; rs988560; rs6839555; rs7682027; rs3100; rs9994887; rs1580083; rs7377952; rs7696472; rs6825748; rs13128530; rs1968719; rs1968718; rs7654523; rs1026337; rs1947435; rs1026338; rs2278917; rs1160212; rs12500760; rs4048844; rs7377954; rs12647504; rs4148271; rs2168050; rs2168051; rs6858676; rs35791822; rs13112099; rs7377950; rs34930215; rs17324486; rs5017546; rs2877378; rs1947434; rs5017549; rs17221777; rs35601514; rs6839657; rs11371462; rs5017544; rs2331421; rs2331422; rs6820752; rs4694747; rs12108552; rs34214136; rs4426857; rs35503231; rs5017548; rs35397066; rs5859136; rs2877377; rs10549990; rs2331423; rs5017545; rs34618890; rs5017547; rs5029385; rs1026339; rs5859137; rs34498614; rs34207963; rs3966095; rs1902023; rs4148269

# Metabolic_Enzyme_23_General_References:
7835232; 9295060; 2116769

# Metabolic_Enzyme_23_References:
Not Available

# Metabolic_Enzyme_24_ID:
5319

# Metabolic_Enzyme_24_Name:
Tyrosinase precursor

# Metabolic_Enzyme_24_Synonyms:
Monophenol monooxygenase; Tumor rejection antigen AB; SK29-AB; LB24-AB

# Metabolic_Enzyme_24_Gene_Name:
TYR

# Metabolic_Enzyme_24_Protein_Sequence:
>Tyrosinase precursor
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILL
SNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVR
RNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMH
YYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRD
AEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRN
PGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQS
SMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGH
NRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLG
AAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL

# Metabolic_Enzyme_24_Number_of_Residues:
529

# Metabolic_Enzyme_24_Molecular_Weight:
60394

# Metabolic_Enzyme_24_Theoretical_pI:
6.05

# Metabolic_Enzyme_24_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_24_General_Function:
Not Available

# Metabolic_Enzyme_24_Specific_Function:
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone

# Metabolic_Enzyme_24_Pathway:
map00350  Tyrosine metabolism;
 map00740  Riboflavin metabolism;
 map00940  Stilbene, coumarine and lignin biosynthesis;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_24_Reaction:
L-tyrosine + L-dopa + O2 = L-dopa + dopaquinone + H2O

# Metabolic_Enzyme_24_Pfam_Domain_Function:
PF00264:Tyrosinase

# Metabolic_Enzyme_24_Signals:
1-18

# Metabolic_Enzyme_24_Transmembrane_Regions:
477-497

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 1.14.18.1

# Metabolic_Enzyme_24_GenBank_ID_Protein:
340037

# Metabolic_Enzyme_24_SwissProt_ID:
TYRO_HUMAN (P14679)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
TYR

# Metabolic_Enzyme_24_Geneatlas_id:
TYR

# Metabolic_Enzyme_24_hgnc_id:
HGNC:12442

# Metabolic_Enzyme_24_PDB_ID:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Melanosome; melanosomal membrane; single- pass type I membrane protein

# Metabolic_Enzyme_24_Gene_Sequence:
>1590 bp
ATGCTCCTGGCTGTTTTGTACTGCCTGCTGTGGAGTTTCCAGACCTCCGCTGGCCATTTC
CCTAGAGCCTGTGTCTCCTCTAAGAACCTGATGGAGAAGGAATGCTGTCCACCGTGGAGC
GGGGACAGGAGTCCCTGTGGCCAGCTTTCAGGCAGAGGTTCCTGTCAGAATATCCTTCTG
TCCAATGCACCACTTGGGCCTCAATTTCCCTTCACAGGGGTGGATGACCGGGAGTCGTGG
CCTTCCGTCTTTTATAATAGGACCTGCCAGTGCTCTGGCAACTTCATGGGATTCAACTGT
GGAAACTGCAAGTTTGGCTTTTGGGGACCAAACTGCACAGAGAGACGACTCTTGGTGAGA
AGAAACATCTTCGATTTGAGTGCCCCAGAGAAGGACAAATTTTTTGCCTACCTCACTTTA
GCAAAGCATACCATCAGCTCAGACTATGTCATCCCCATAGGGACCTATGGCCAAATGAAA
AATGGATCAACACCCATGTTTAACGACATCAATATTTATGACCTCTTTGTCTGGATGCAT
TATTATGTGTCAATGGATGCACTGCTTGGGGGATCTGAAATCTGGAGAGACATTGATTTT
GCCCATGAAGCACCAGCTTTTCTGCCTTGGCATAGACTCTTCTTGTTGCGGTGGGAACAA
GAAATCCAGAAGCTGACAGGAGATGAAAACTTCACTATTCCATATTGGGACTGGCGGGAT
GCAGAAAAGTGTGACATTTGCACAGATGAGTACATGGGAGGTCAGCACCCCACAAATCCT
AACTTACTCAGCCCAGCATCATTCTTCTCCTCTTGGCAGATTGTCTGTAGCCGATTGGAG
GAGTACAACAGCCATCAGTCTTTATGCAATGGAACGCCCGAGGGACCTTTACGGCGTAAT
CCTGGAAACCATGACAAATCCAGAACCCCAAGGCTCCCCTCTTCAGCTGATGTAGAATTT
TGCCTGAGTTTGACCCAATATGAATCTGGTTCCATGGATAAAGCTGCCAATTTCAGCTTT
AGAAATACACTGGAAGGATTTGCTAGTCCACTTACTGGGATAGCGGATGCCTCTCAAAGC
AGCATGCACAATGCCTTGCACATCTATATGAATGGAACAATGTCCCAGGTACAGGGATCT
GCCAACGATCCTATCTTCCTTCTTCACCATGCATTTGTTGACAGTATTTTTGAGCAGTGG
CTCCGAAGGCACCGTCCTCTTCAAGAAGTTTATCCAGAAGCCAATGCACCCATTGGACAT
AACCGGGAATCCTACATGGTTCCTTTTATACCACTGTACAGAAATGGTGATTTCTTTATT
TCATCCAAAGATCTGGGCTATGACTATAGCTATCTACAAGATTCAGACCCAGACTCTTTT
CAAGACTACATTAAGTCCTATTTGGAACAAGCGAGTCGGATCTGGTCATGGCTCCTTGGG
GCGGCGATGGTAGGGGCCGTCCTCACTGCCCTGCTGGCAGGGCTTGTGAGCTTGCTGTGT
CGTCACAAGAGAAAGCAGCTTCCTGAAGAAAAGCAGCCACTCCTCATGGAGAAAGAGGAT
TACCACAGCTTGTATCAGAGCCATTTATAA

# Metabolic_Enzyme_24_GenBank_ID_Gene:
M27160

# Metabolic_Enzyme_24_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_24_Locus:
11q14-q21

# Metabolic_Enzyme_24_SNPs:
rs33955261; rs1042602; rs1126809; rs1042608; rs4987234; rs3913543; rs3913544; rs1502267; rs3913542; rs1827430; rs1432447; rs12799137; rs2186640; rs12273884; rs6483004; rs11018524; rs12803764; rs621313; rs7358418; rs7117973; rs7929991; rs11018541; rs6483000; rs11820797; rs10765196; rs11824837; rs4753215; rs11018528; rs12420237; rs1393350; rs12804012; rs4399330; rs7108676; rs6483008; rs6483001; rs12419949; rs1939258; rs7940773; rs7945829; rs6483006; rs591260; rs574028; rs7929015; rs12419351; rs12808785; rs6483002; rs4396293; rs501301; rs3900053; rs11018530; rs7115192; rs6483007; rs7123654; rs7940760; rs10765197; rs9919559; rs3793974; rs16913104; rs1847142; rs7943909; rs16913107; rs7107143; rs17793750; rs7111110; rs12418383; rs1939253; rs4121403; rs7947262; rs2000554; rs12420674; rs12416719; rs1847134; rs12419364; rs7115568; rs11018525; rs12418646; rs7941532; rs11820635; rs7105390; rs12419262; rs16912259; rs6483003; rs2866556; rs12808381; rs7123206; rs3793976; rs10765200; rs10830241; rs12791412; rs12786274; rs16913039; rs2000553; rs7112373; rs7927996; rs7941110; rs12417182; rs12420662; rs11823675; rs10830250; rs7941686; rs12420278; rs4121401; rs7117190; rs12421397; rs4418813; rs12807810; rs12789914; rs10765198; rs10741305; rs12808354; rs12421155; rs12417077; rs12418148; rs11824443; rs10765201; rs2002720; rs1942493; rs12098971; rs12806466; rs7101897; rs1939255; rs2298458; rs17174064; rs7924589; rs11018544; rs10501700; rs12421402; rs12417632; rs3793975; rs7117826; rs10830253; rs17191474; rs12419341; rs12420348; rs594647; rs7129973; rs12280928; rs7117213; rs16912972; rs16912981; rs11018522; rs12417166; rs7103781; rs12280693; rs11820834; rs10830245; rs1939262; rs12799347; rs7933595; rs10830248; rs12808219; rs7942587; rs12421746; rs12574987; rs7940368; rs4601783; rs16913084; rs12420864; rs12419071; rs7116589; rs16913095; rs10501698; rs11018549; rs12416958; rs7925659; rs7358330; rs12270717; rs12365043; rs12421030; rs12577992; rs16912983; rs11018555; rs12793071; rs11018545; rs11018535; rs16912966; rs11828655; rs7947052; rs11828731; rs12795158; rs3936992; rs1939263; rs9919546; rs4290229; rs660491; rs10830240; rs7933594; rs16912262; rs7117255; rs11821815; rs575429; rs10830249; rs6482999; rs1074304; rs10830244; rs11018542; rs11018548; rs17793678; rs645592; rs11018553; rs12799516; rs598769; rs10765199; rs4087499; rs16913089; rs10501699; rs16913011; rs1939251; rs4753214; rs7935604; rs11018543; rs12421505; rs10830239; rs12417327; rs11018532; rs7939929; rs6415994; rs2000555; rs12795171; rs7925468; rs2155148; rs7103787; rs16913040; rs11018562; rs1939252; rs12286618; rs7116973; rs12363772; rs10830243; rs12808283; rs7943159; rs16912994; rs7116716; rs7936840; rs9736253; rs4512823; rs3936623; rs7929736; rs11018539; rs535527; rs2155149; rs2155147; rs12803765; rs877072; rs10830247; rs10830246; rs7934212; rs12417026; rs7117974; rs6485980; rs10830238; rs12799768; rs7924913; rs525883; rs12418178; rs12288824; rs12792733; rs12799349; rs4542415; rs12792959; rs1892924; rs4547091; rs1799989; rs5021654; rs7930949; rs7940945; rs28940878; rs13312744; rs13312739; rs34297847; rs34878847; rs13312741; rs28940880; rs11545463; rs13312740; rs11826502; rs11824499; rs11545464; rs28940877; rs28940879; rs36006590; rs28940876; rs28940881; rs13312743; rs1939261; rs1939260; rs35541275; rs1800421; rs13312738; rs34814690; rs11453031; rs36041295; rs1939254; rs7121593; rs34175287; rs7951381; rs11018554; rs35062445; rs34947445; rs34656455; rs11411684; rs28634864; rs11018559; rs11018540; rs34017963; rs34698766; rs2134299; rs12788302; rs35963892; rs12786392; rs11018547; rs36137175; rs1060297; rs34202080; rs12788985; rs12365772; rs12578000; rs35218219; rs12788993; rs11018560; rs4121402; rs35026809; rs35311585; rs4121397; rs5793396; rs17852431; rs36124916; rs7929045; rs4561218; rs34486762; rs34289520; rs35905469; rs34003066; rs4429061; rs34661861; rs4987235; rs12796520; rs34703992; rs28578270; rs34373463; rs11018523; rs34739346; rs12786829; rs905283; rs5793397; rs12277937; rs11018527; rs34899701; rs34429128; rs34758368; rs34773602; rs1074303; rs36055732; rs12803508; rs13312742; rs16913082; rs36007597; rs12804213; rs35654391; rs10526067; rs28620862; rs12791524; rs35555968; rs11018536; rs7396600; rs10551522; rs34876778; rs11018556; rs1783963; rs35928779; rs7946027; rs12786751; rs7924312; rs4079453; rs4087500; rs3907204; rs35930733; rs35724269; rs12804722; rs7934646; rs35477235; rs35801536; rs34425156; rs41320146; rs1939257; rs12789480; rs34675404; rs12805094; rs11018550; rs35501966; rs35514600; rs34903891; rs12803535; rs12294360; rs4512825; rs34634444; rs592486; rs17852430; rs35663695; rs10573250; rs12788260; rs35032790; rs34621048; rs12099254; rs34873297; rs694934; rs34700959; rs4611200; rs7127196; rs35103430; rs35217407; rs35464565; rs5793398; rs10547762; rs16913085; rs34422026; rs7928821; rs35222097; rs34604882; rs609630; rs12796336; rs10671315; rs35457014; rs12271965; rs7946211; rs12805443; rs35434176; rs12789834; rs4121400; rs12146614; rs35105852; rs3907205; rs35774080; rs35744603; rs1939256; rs35428928; rs648871; rs35937494; rs582480; rs12786390; rs625401; rs11018563; rs12797237; rs636613; rs12788232; rs12807511; rs35959534; rs34067617; rs36098386; rs12788214; rs35518533; rs7112858; rs5793399; rs34584385; rs35607520; rs11018557; rs12805030; rs12574349; rs2008320; rs516696; rs35526885; rs12805221; rs35342940; rs11018551; rs1847136; rs11018538; rs11018546; rs34530512; rs34857319; rs35029283; rs11018534; rs1074305; rs35523924; rs12789159; rs35300336; rs11517465; rs603082; rs34295137; rs28826427; rs34469199; rs12787683; rs35430241; rs35115224; rs35597809; rs12295166; rs4614456; rs905281; rs10583155; rs35770150; rs34754918; rs7924785; rs35581621; rs1987513; rs12786588; rs2173998; rs33998063; rs12285584; rs12805029; rs11381844; rs12099178; rs11018558; rs28625671; rs4121398; rs35531191; rs649687; rs7927845; rs34029150; rs35008750; rs7122606; rs475629; rs34865967; rs34625776; rs35549872; rs4121399; rs35764186; rs3834913; rs7483274; rs11018526; rs12786201; rs1939259; rs28625370; rs35804290; rs34388247; rs16912961; rs35195697; rs7105284; rs35638921; rs7119171; rs12364170; rs10691193; rs28521275; rs11374501; rs10830237; rs11824466; rs11827921; rs12795279; rs1954771; rs35402334; rs7949856; rs949537; rs949538

# Metabolic_Enzyme_24_General_References:
1903356; 2823263; 2499655; 1711223; 8340755; 11153699; 2480811; 2504160; 11214319; 8477259; 10094567; 2342539; 1970634; 1903591; 1642278; 1899321; 1900309; 1943686; 1487241; 7902671; 8128955; 7955413; 8644824; 9158138; 9259202; 10987646; 10571953; 11295837; 11858948

# Metabolic_Enzyme_24_References:
3127403; 8003445

# Macromolecular_Interacting_Partner_1_ID:
7546

# Macromolecular_Interacting_Partner_1_Name:
Prolactin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
PRL

# Macromolecular_Interacting_Partner_1_Gene_Name:
PRL

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Prolactin precursor
MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN
EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG
LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
227

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
25876

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.99

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Prolactin acts primarily on the mammary gland by promoting lactation

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_1_Signals:
1-28

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
34211

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
PRL_HUMAN (P01236)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
PRL

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
PRL

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9445

# Macromolecular_Interacting_Partner_1_PDB_ID:
1RW5

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>684 bp
ATGAACATCAAAGGATCGCCATGGAAAGGGTCCCTCCTGCTGCTGCTGGTGTCAAACCTG
CTGCTGTGCCAGAGCGTGGCCCCCTTGCCCATCTGTCCCGGCGGGGCTGCCCGATGCCAG
GTGACCCTTCGAGACCTGTTTGACCGCGCCGTCGTCCTGTCCCACTACATCCATAACCTC
TCCTCAGAAATGTTCAGCGAATTCGATAAACGGTATACCCATGGCCGGGGGTTCATTACC
AAGGCCATCAACAGCTGCCACACTTCTTCCCTTGCCACCCCCGAAGACAAGGAGCAAGCC
CAACAGATGAATCAAAAAGACTTTCTGAGCCTGATAGTCAGCATATTGCGATCCTGGAAT
GAGCCTCTGTATCATCTGGTCACGGAAGTACGTGGTATGCAAGAAGCCCCGGAGGCTATC
CTATCCAAAGCTGTAGAGATTGAGGAGCAAACCAAACGGCTTCTAGAGGGCATGGAGCTG
ATAGTCAGCCAGGTTCATCCTGAAACCAAAGAAAATGAGATCTACCCTGTCTGGTCGGGA
CTTCCATCCCTGCAGATGGCTGATGAAGAGTCTCGCCTTTCTGCTTATTATAACCTGCTC
CACTGCCTACGCAGGGATTCACATAAAATCGACAATTATCTCAAGCTCCTGAAGTGCCGA
ATCATCCACAACAACAACTGCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00566

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_1_Locus:
6p22.2-p21.3

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
6260780; 6325171; 2050267; 6146607; 9266104; 925136; 1126929

# Macromolecular_Interacting_Partner_1_References:
11726571; 12846361; 15528265; 2501380

# Macromolecular_Interacting_Partner_2_ID:
7559

# Macromolecular_Interacting_Partner_2_Name:
Estrogen receptor

# Macromolecular_Interacting_Partner_2_Synonyms:
ER; Estradiol receptor; ER-alpha

# Macromolecular_Interacting_Partner_2_Gene_Name:
ESR1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Estrogen receptor
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
595

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
66217

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
8.14

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  steroid binding
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF02159:Oest_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
31620888

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
ESR1_HUMAN (P03372)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
ESR1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
ESR1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:3467

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>63 bp
ATGCGCTGCGTCGCCTCTAACCTCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTC
TGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
X03635

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_2_Locus:
6q25.1

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
3753802; 3754034; 8600466; 14574404; 10619354; 7916651; 7476978; 7539106; 1577818; 7838153; 9627117; 10428798; 10567404; 10359819; 11113208; 11971969; 12415108; 2247153; 8221895; 9338790; 9600906; 9875847; 9619507; 2792078; 8961262; 9195227

# Macromolecular_Interacting_Partner_2_References:
11178903; 11882509; 16728493; 2011412

# Macromolecular_Interacting_Partner_3_ID:
6946

# Macromolecular_Interacting_Partner_3_Name:
Sex hormone-binding globulin precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
SHBG; Sex steroid-binding protein; SBP; Testis-specific androgen-binding protein; ABP; Testosterone-estrogen-binding globulin; Testosterone-estradiol- binding globulin; TeBG

# Macromolecular_Interacting_Partner_3_Gene_Name:
SHBG

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Sex hormonebinding globulin precursor
MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMT
FDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGA
GPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPAS
NLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDI
PQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPL
VLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTS
FCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
402

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
43780

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.70

# Macromolecular_Interacting_Partner_3_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00054:Laminin_G_1

# Macromolecular_Interacting_Partner_3_Signals:
1-29

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
296673

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
SHBG_HUMAN (P04278)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SHBG

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SHBG

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:10839

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis (By similarity)

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1209 bp
ATGGAGAGCAGAGGCCCACTGGCTACCTCGCGCCTGCTGCTGTTGCTGCTGTTGCTACTA
CTGCGTCACACCCGCCAGGGATGGGCCCTGAGACCTGTTCTCCCCACCCAGAGTGCCCAC
GACCCTCCGGCTGTCCACCTCAGCAATGGCCCAGGACAAGAGCCTATCGCTGTCATGACC
TTTGACCTCACCAAGATCACAAAAACCTCCTCCTCCTTTGAGGTTCGAACCTGGGACCCA
GAGGGAGTGATTTTTTATGGGGATACCAACCCTAAGGATGACTGGTTTATGCTGGGACTT
CGAGACGGCAGGCCTGAGATCCAACTGCACAATCACTGGGCCCAGCTTACGGTGGGTGCT
GGACCACGGCTGGATGATGGGAGATGGCACCAGGTGGAAGTCAAGATGGAGGGGGACTCT
GTGCTGCTGGAGGTGGATGGGGAGGAGGTGCTGCGCCTGAGACAGGTCTCTGGGCCCCTG
ACCAGCAAACGCCATCCCATCATGAGGATTGCGCTTGGGGGGCTGCTCTTCCCCGCTTCC
AACCTTCGGTTGCCGCTGGTTCCTGCCCTGGATGGCTGCCTGCGCCGGGATTCCTGGCTG
GACAAACAGGCCGAGATCTCAGCATCTGCCCCCACTAGCCTCAGAAGCTGTGATGTAGAA
TCAAATCCCGGGATATTTCTCCCTCCAGGGACTCAGGCAGAATTCAATCTCCGAGACATT
CCCCAGCCTCATGCAGAGCCCTGGGCCTTCTCTTTGGACCTGGGACTCAAGCAGGCAGCA
GGCTCAGGCCACCTCCTTGCTCTTGGGACACCAGAGAACCCATCTTGGCTCAGTCTCCAC
CTCCAAGATCAAAAGGTGGTGTTGTCTTCTGGGTCGGGGCCAGGGCTGGATCTGCCCCTG
GTCTTGGGACTCCCTCTTCAGCTGAAGCTGAGTATGTCCAGGGTGGTCTTGAGCCAAGGG
TCGAAGATGAAGGCCCTTGCCCTGCCTCCCTTAGGCCTGGCTCCCCTCCTTAACCTCTGG
GCCAAGCCTCAAGGGCGTCTCTTCCTGGGGGCTTTACCAGGAGAAGACTCTTCCACCTCT
TTTTGCCTGAATGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAAC
AGAAGCCATGAGATCTGGACTCACAGCTGCCCCCAGAGCCCAGGCAATGGCACTGACGCT
TCCCATTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
X16349

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_3_Locus:
17p13-p12

# Macromolecular_Interacting_Partner_3_SNPs:
rs6260; rs6258; rs9282845; rs6259; rs6261; rs4987212; rs9282846; rs6257; rs9913778; rs858517; rs1799941; rs858516; rs35167070; rs34865989; rs34420533; rs35338190; rs3760213; rs8065089; rs5030659; rs13894; rs1641536; rs1641537; rs1641544; rs1642800; rs2543553; rs2955617; rs34780532; rs727428; rs858520; rs858521; rs9898876

# Macromolecular_Interacting_Partner_3_General_References:
2587256; 2608061; 3569533; 2956126; 2956125; 3702459; 3542030; 1400872; 10675319; 12065592; 7714097; 10391209

# Macromolecular_Interacting_Partner_3_References:
11726571; 3357338

# Macromolecular_Interacting_Partner_4_ID:
7010

# Macromolecular_Interacting_Partner_4_Name:
Proactivator polypeptide precursor [Contains: Saposin A

# Macromolecular_Interacting_Partner_4_Synonyms:
Protein A; Saposin B-Val; Saposin B; Sphingolipid activator protein 1; SAP-1; Cerebroside sulfate activator; CSAct; Dispersin; Sulfatide/GM1 activator; Saposin C; Co-beta-glucosidase; A1 activator; Glucosylceramidase activator; Sphingolipid activator protein 2; SAP-2; Saposin D; Protein C; Component C]

# Macromolecular_Interacting_Partner_4_Gene_Name:
PSAP

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Proactivator polypeptide precursor Contains: Saposin 
AMYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVK
SLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILD
IIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLL
YPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMAD
ICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELV
EPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQE
VVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYL
DRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKI
GACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
524

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
58113

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
4.82

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  sphingolipid metabolism
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  vacuole
Component:  lytic vacuole
Component:  lysosome

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Saposin D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12)

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF02199:SapA;
PF05184:SapB_1;
PF03489:SapB_2

# Macromolecular_Interacting_Partner_4_Signals:
1-16

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
220064

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
SAP_HUMAN (P07602)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
PSAP

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
PSAP

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:9498

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Lysosome

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1584 bp
ATGTACGCCCTCTTCCTCCTGGCCAGCCTCCTGGGCGCGGCTCTAGCCGGCCCGGTCCTT
GGACTGAAAGAATGCACCAGGGGCTCGGCAGTGTGGTGCCAGAATGTGAAGACGGCGTCC
GACTGCGGGGCAGTGAAGCACTGCCTGCAGACCGTTTGGAACAAGCCAACAGTGAAATCC
CTTCCCTGCGACATATGCAAAGACGTTGTCACCGCAGCTGGTGATATGCTGAAGGACAAT
GCCACTGAGGAGGAGATCCTTGTTTACTTGGAGAAGACCTGTGACTGGCTTCCGAAACCG
AACATGTCTGCTTCATGCAAGGAGATAGTGGACTCCTACCTCCCTGTCATCCTGGACATC
ATTAAAGGAGAAATGAGCCGTCCTGGGGAGGTGTGCTCTGCTCTCAACCTCTGCGAGTCT
CTCCAGAAGCACCTAGCAGAGCTGAATCACCAGAAGCAGCTGGAGTCCAATAAGATCCCA
GAGCTGGACATGACTGAGGTGGTGGCCCCCTTCATGGCCAACATCCCTCTCCTCCTCTAC
CCTCAGGACGGCCCCCGCAGCAAGCCCCAGCCAAAGGATAATGGGGACGTTTGCCAGGAC
TGCATTCAGATGGTGACTGACATCCAGACTGCTGTACGGACCAACTCCACCTTTGTCCAG
GCCTTGGTGGAACATGTCAAGGAGGAGTGTGACCGCCTGGGCCCTGGCATGGCCGACATA
TGCAAGAACTATATCAGCCAGTATTCTGAAATTGCTATCCAGATGATGATGCACATGCAG
GATCAGCAACCCAAGGAGATCTGTGCGCTGGTTGGGTTCTGTGATGAGGTGAAAGAGATG
CCCATGCAGACTCTGGTCCCCGCCAAAGTGGCCTCCAAGAATGTCATCCCTGCCCTGGAA
CTGGTGGAGCCCATTAAGAAGCACGAGGTCCCAGCAAAGTCTGATGTTTACTGTGAGGTG
TGTGAATTCCTGGTGAAGGAGGTGACCAAGCTGATTGACAACAACAAGACTGAGAAAGAA
ATACTCGACGCTTTTGACAAAATGTGCTCGAAGCTGCCGAAGTCCCTGTCGGAAGAGTGC
CAGGAGGTGGTGGACACGTACGGCAGCTCCATCCTGTCCATCCTGCTGGAGGAGGTCAGC
CCTGAGCTGGTGTGCAGCATGCTGCACCTCTGCTCTGGCACGCGGCTGCCTGCACTGACC
GTTCACGTGACTCAGCCAAAGGACGGTGGCTTCTGCGAAGTGTGCAAGAAGCTGGTGGGT
TATTTGGATCGCAACCTGGAGAAAAACAGCACCAAGCAGGAGATCCTGGCTGCTCTTGAG
AAAGGCTGCAGCTTCCTGCCAGACCCTTACCAGAAGCAGTGTGATCAGTTTGTGGCAGAG
TACGAGCCCGTGCTGATCGAGATCCTGGTGGAGGTGATGGATCCTTCCTTCGTGTGCTTG
AAAATTGGAGCCTGCCCCTCGGCCCATAAGCCCTTGTTGGGAACTGAGAAGTGTATATGG
GGCCCAAGCTACTGGTGCCAGAACACAGAGACAGCAGCCCAGTGCAATGCTGTCGAGCAT
TGCAAACGCCATGTGTGGAACTAG

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
D00422

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_4_Locus:
10q21-q22

# Macromolecular_Interacting_Partner_4_SNPs:
rs2070188; rs7869; rs1055754; rs2394846; rs762571; rs1015193; rs4237331; rs720295; rs7899959; rs7905774; rs7922255; rs885828; rs4237332; rs4747202; rs4747206; rs2070968; rs2394845; rs4747207; rs1900498; rs7350390; rs728289; rs2394844; rs6480560; rs9663508; rs2593163; rs749823; rs3747860; rs6480561; rs3819341; rs6480559; rs11000017; rs10740391; rs727414; rs2249814; rs2121535; rs7912803; rs2854986; rs7093252; rs10823852; rs3747855; rs11000020; rs16929408; rs11598989; rs11596365; rs4747203; rs12413995; rs10762483; rs4747204; rs4747208; rs11000016; rs12414356; rs2854992; rs11000025; rs727415; rs4747205; rs2166630; rs16913438; rs10762484; rs2854987; rs1900499; rs4454640; rs7917605; rs11000018; rs12413014; rs4746095; rs10762482; rs12415202; rs762573; rs12769743; rs1811087; rs2290023; rs7918049; rs11813373; rs9665661; rs11592448; rs9415055; rs11591470; rs7916568; rs7917015; rs11818931; rs2394843; rs11000019; rs4747209; rs7898293; rs4747210; rs11598617; rs9299509; rs9299510; rs12261323; rs1803650; rs11555015; rs11555016; rs11555021; rs11555017; rs1049882; rs1056711; rs1054851; rs1054293; rs11555018; rs41282246; rs11555020; rs36076120; rs14595; rs1053333; rs12844; rs28365839; rs1803651; rs2121536; rs7090110; rs11596605; rs35320964; rs34332602; rs2593164; rs11000024; rs7091271; rs9416009; rs2854984; rs5786051; rs34551152; rs11415214; rs2593162; rs5786050; rs959189; rs7898921; rs1894270; rs8181334; rs7477139; rs35814383; rs36035697; rs11595017; rs1867981; rs12266725; rs9416010; rs7072424; rs2854990; rs7098225; rs11277133; rs35027678; rs12220614; rs5786049; rs11000023; rs28535035; rs12571681; rs35131935; rs12247334; rs34701833; rs9415054; rs12782637; rs12252719; rs41307569; rs7922360; rs2854989; rs7911004; rs11285654; rs3061818; rs2593161; rs11000026; rs2854985; rs2854991; rs11305283; rs7899796; rs34761785; rs7072021; rs11000021; rs12247599; rs2854988; rs7076038; rs5007340; rs10566090; rs2305203; rs41306532; rs3891337; rs762572; rs5007339; rs10566091; rs2593160; rs3878001; rs35837949; rs7068078; rs35439306; rs12217799; rs35407936; rs34509443; rs35534537; rs2121537; rs35068924; rs11598625; rs34150455; rs28365838; rs7897854; rs34228343; rs10390; rs1054635; rs10762485; rs11000030; rs12252818; rs12416292; rs12774485; rs13377076; rs16929375; rs16929427; rs1867978; rs1992823; rs2290021; rs2290022; rs2394840; rs3802707; rs4746097; rs4747197; rs4747198; rs4747199; rs6480562; rs7085713; rs7092990; rs9415051; rs9415053

# Macromolecular_Interacting_Partner_4_General_References:
2515150; 2498298; 2842863; 1612590; 8323276; 1958198; 2013321; 2717620; 8370464; 2825202; 2868718; 3242555; 2209618; 3442600; 2845979; 3048308; 10562467; 7730378; 11180632; 10406958; 12510003; 10510427; 12518053; 7866401; 2302219; 2320574; 2019586; 2060627

# Macromolecular_Interacting_Partner_4_References:
1888678; 9521983

# Macromolecular_Interacting_Partner_5_ID:
5688

# Macromolecular_Interacting_Partner_5_Name:
Estrogen receptor beta

# Macromolecular_Interacting_Partner_5_Synonyms:
ER-beta

# Macromolecular_Interacting_Partner_5_Gene_Name:
ESR2

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Estrogen receptor beta
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
530

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
59217

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
8.55

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  steroid binding
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
2911152

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
ESR2_HUMAN (Q92731)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
ESR2

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
ESR2

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:3468

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1593 bp
ATGGATATAAAAAACTCACCATCTAGCCTTAATTCTCCTTCCTCCTACAACTGCAGTCAA
TCCATCTTACCCCTGGAGCACGGCTCCATATACATACCTTCCTCCTATGTAGACAGCCAC
CATGAATATCCAGCCATGACATTCTATAGCCCTGCTGTGATGAATTACAGCATTCCCAGC
AATGTCACTAACTTGGAAGGTGGGCCTGGTCGGCAGACCACAAGCCCAAATGTGTTGTGG
CCAACACCTGGGCACCTTTCTCCTTTAGTGGTCCATCGCCAGTTATCACATCTGTATGCG
GAACCTCAAAAGAGTCCCTGGTGTGAAGCAAGATCGCTAGAACACACCTTACCTGTAAAC
AGAGAGACACTGAAAAGGAAGGTTAGTGGGAACCGTTGCGCCAGCCCTGTTACTGGTCCA
GGTTCAAAGAGGGATGCTCACTTCTGCGCTGTCTGCAGCGATTACGCATCGGGATATCAC
TATGGAGTCTGGTCGTGTGAAGGATGTAAGGCCTTTTTTAAAAGAAGCATTCAAGGACAT
AATGATTATATTTGTCCAGCTACAAATCAGTGTACAATCGATAAAAACCGGCGCAAGAGC
TGCCAGGCCTGCCGACTTCGGAAGTGTTACGAAGTGGGAATGGTGAAGTGTGGCTCCCGG
AGAGAGAGATGTGGGTACCGCCTTGTGCGGAGACAGAGAAGTGCCGACGAGCAGCTGCAC
TGTGCCGGCAAGGCCAAGAGAAGTGGCGGCCACGCGCCCCGAGTGCGGGAGCTGCTGCTG
GACGCCCTGAGCCCCGAGCAGCTAGTGCTCACCCTCCTGGAGGCTGAGCCGCCCCATGTG
CTGATCAGCCGCCCCAGTGCGCCCTTCACCGAGGCCTCCATGATGATGTCCCTGACCAAG
TTGGCCGACAAGGAGTTGGTACACATGATCAGCTGGGCCAAGAAGATTCCCGGCTTTGTG
GAGCTCAGCCTGTTCGACCAAGTGCGGCTCTTGGAGAGCTGTTGGATGGAGGTGTTAATG
ATGGGGCTGATGTGGCGCTCAATTGACCACCCCGGCAAGCTCATCTTTGCTCCAGATCTT
GTTCTGGACAGGGATGAGGGGAAATGCGTAGAAGGAATTCTGGAAATCTTTGACATGCTC
CTGGCAACTACTTCAAGGTTTCGAGAGTTAAAACTCCAACACAAAGAATATCTCTGTGTC
AAGGCCATGATCCTGCTCAATTCCAGTATGTACCCTCTGGTCACAGCGACCCAGGATGCT
GACAGCAGCCGGAAGCTGGCTCACTTGCTGAACGCCGTGACCGATGCTTTGGTTTGGGTG
ATTGCCAAGAGCGGCATCTCCTCCCAGCAGCAATCCATGCGCCTGGCTAACCTCCTGATG
CTCCTGTCCCACGTCAGGCATGCGAGTAACAAGGGCATGGAACATCTGCTCAACATGAAG
TGCAAAAATGTGGTCCCAGTGTATGACCTGCTGCTGGAGATGCTGAATGCCCACGTGCTT
CGCGGGTGCAAGTCCTCCATCACGGGGTCCGAGTGCAGCCCGGCAGAGGACAGTAAAAGC
AAAGAGGGCTCCCAGAACCCACAGTCTCAGTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AB006590

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_5_Locus:
14q23.2

# Macromolecular_Interacting_Partner_5_SNPs:
rs1256049; rs1541060; rs1256054; rs928554; rs1271572; rs2987983; rs1952586; rs6573553; rs4986938; rs1571512; rs3020445; rs2978381; rs3020450; rs12436302; rs10137185; rs3783736; rs2357479; rs1887994; rs3020444; rs1255998; rs11625778; rs17101774; rs9788441; rs8018687; rs6573552; rs10146107; rs1256120; rs17226046; rs10146464; rs7159462; rs8011682; rs2978382; rs17226060; rs11629158; rs6573554; rs10483774; rs10136822; rs3020447; rs3020446; rs1256027; rs7146908; rs10047818; rs17226088; rs10142856; rs12432174; rs3020443; rs3829768; rs8008187; rs3020449; rs2987976; rs1256029; rs12436533; rs17179740; rs10142766; rs8019025; rs35000350; rs17226081; rs12436325; rs17101765; rs12589834; rs35142532; rs34996860; rs1256033; rs944459; rs1256044; rs1256065; rs1269056; rs1952585; rs944045; rs1256056; rs944460; rs1152577; rs1152579; rs960070; rs1256030; rs1256031; rs1152578; rs1256061; rs1256066; rs867443; rs1256037; rs1256039; rs4365213; rs944050; rs1256036; rs1256059; rs10148269; rs1256048; rs6573549; rs1256043; rs1256063; rs1256064; rs1152580; rs12432029; rs8006145; rs944461; rs8017441; rs8003490; rs1256062; rs960069; rs1256045; rs7154455; rs1256041; rs11844783; rs11850375; rs1256046; rs6573551; rs12435284; rs10144225; rs12435857; rs1256055; rs17225885; rs7151379; rs1760988; rs1256040; rs6573550; rs1152576; rs1256047; rs10143616; rs1109056; rs2274705; rs953592; rs1256038; rs1256032; rs12437103; rs8022377; rs944458; rs12435307; rs1256042; rs8021763; rs10136955; rs17101734; rs944046; rs10143846; rs10459452; rs11621314; rs8020356; rs17766755; rs4991135; rs1152581; rs1273196; rs12435278; rs1256060; rs1256052; rs7157428; rs3742614; rs17101732; rs12436020; rs8003034; rs1256050; rs35743760; rs1256053; rs1271573; rs1256034; rs944047; rs34335763; rs8004907; rs8005720; rs28560770; rs7150504; rs28533821; rs35470913; rs36101201; rs10586023; rs35977223; rs1256122; rs12878151; rs35838376; rs11849012; rs12896657; rs10142387; rs12896460; rs8012102; rs12878171; rs12896656; rs1256028; rs34279976; rs34042570; rs34379325; rs28663685; rs12878317; rs35178946; rs12434123; rs12888944; rs1256121; rs12323665; rs35444147; rs10137994; rs34259492; rs10542764; rs12878448; rs33911435; rs35524660; rs10559131; rs8020953; rs28590754; rs28440970; rs35626954; rs28791544; rs10139423; rs2738411; rs3832949; rs12880680; rs28862689; rs35325527; rs12878147; rs35415214; rs35309509; rs34365161; rs8004284; rs12896484; rs35805395; rs34422347; rs35945666; rs35000680; rs2987980; rs34187403; rs7150300; rs3783734; rs34429939; rs28858114; rs3841304; rs12892242; rs28402888; rs35866794; rs12323439; rs33938319; rs12892235; rs8014219; rs2987975; rs9788467; rs28811117; rs34974677; rs28659912; rs11325384; rs2031960; rs10628372; rs36108515; rs35006597; rs9788542; rs2978380; rs35559445; rs34837234; rs12878447; rs3783735; rs28871406; rs28435160; rs2983748; rs10564800; rs12894175; rs12893594; rs28458963; rs35491543; rs7156924; rs34515626; rs35815260; rs11444056; rs4322568; rs36105498; rs10595890; rs7152484; rs34967796; rs10691382; rs28499370; rs35078414; rs10696080; rs2026086; rs5809224; rs36099966; rs13329021; rs35749298; rs35844028; rs34059608; rs34677580; rs7493519; rs2989401; rs34656479; rs12101211; rs28418648; rs35386350; rs36116809; rs36040036; rs34160122; rs34470395; rs944049; rs11621345; rs28649584; rs7152914; rs36020117; rs4902271; rs34569310; rs11314686; rs10589699; rs1256051; rs12897137; rs7144250; rs5809219; rs2738415; rs5809225; rs34204033; rs1152602; rs34249101; rs867442; rs35340653; rs35650237; rs35350228; rs35261009; rs35044026; rs10629775; rs10557691; rs36098496; rs12894156; rs34433810; rs34478884; rs35412659; rs34972936; rs33977154; rs35308773; rs17101753; rs11851942; rs12883967; rs34136916; rs11441046; rs2776606; rs7159990; rs944048; rs7146434; rs34568139; rs34618726; rs35874406; rs4462498; rs11439683; rs10140457; rs34745821; rs35291917; rs34179608; rs5809222; rs5027281; rs10142498; rs33992698; rs2023141; rs11621342; rs17101742; rs34288779; rs3034336; rs34373341; rs11415529; rs11297817; rs12883941; rs34959266; rs4027300; rs12587432; rs28485225; rs35394904; rs34564792; rs34846309; rs8013331; rs7493535; rs1977487; rs12892916; rs5027282; rs12889431; rs34313437; rs2094914; rs34624204; rs1048312; rs1048315; rs1048350; rs1048357; rs1152582; rs1152583; rs1152584; rs1152585; rs1152588; rs1152589; rs12434245; rs12435338; rs12435395; rs1255997; rs1256112; rs1256114; rs1256116; rs13136; rs17179404; rs2236530; rs2297621; rs2772163; rs34820571; rs35315070; rs35648226; rs35700578; rs35763782; rs35831865; rs7145919; rs7229; rs8020646; rs870404; rs915057; rs9323448; rs941697; rs944051; rs944052

# Macromolecular_Interacting_Partner_5_General_References:
9473491; 9636657; 8769313; 9671811; 9685228; 10964723; 9267036; 9325313; 10681503; 11113208; 12415108

# Macromolecular_Interacting_Partner_5_References:
16728493; 17135036

# Macromolecular_Interacting_Partner_6_ID:
7756

# Macromolecular_Interacting_Partner_6_Name:
Chorionic somatomammotropin hormone precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
Choriomammotropin; Lactogen

# Macromolecular_Interacting_Partner_6_Gene_Name:
CSH1

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Chorionic somatomammotropin hormone precursor
MAPGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEET
YIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLR
SMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHD
ALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
217

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
25021

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
5.30

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Similar to that of somatotropin

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_6_Signals:
1-26

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
35507

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
CSH_HUMAN (P01243)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
CSH1

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
CSH1

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:2440

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>654 bp
ATGGCTGCAGGCTCCCGGACGTCCCTGCTCCTGGCTTTTGCCCTGCTCTGCCTGCCCTGG
CTTCAAGAGGCTGGTGCCGTCCAAACCGTTCCGTTATCCAGGCTTTTTGACCACGCTATG
CTCCAAGCCCATCGCGCGCACCAGCTGGCCATTGACACCTACCAGGAGTTTGAAGAAACC
TATATCCCAAAGGACCAGAAGTATTCATTCCTGCATGACTCCCAGACCTCCTTCTGCTTC
TCAGACTCTATTCCGACACCCTCCAACATGGAGGAAACGCAACAGAAATCCAATCTAGAG
CTGCTCCGCATCTCCCTGCTGCTCATCGAGTCGTGGCTGGAGCCCGTGCGGTTCCTCAGG
AGTATGTTCGCCAACAACCTGGTGTATGACACCTCGGACAGCGATGACTATCACCTCCTA
AAGGACCTAGAGGAAGGCATCCAAACGCTGATGGGGAGGCTGGAAGACGGCAGCCGCCGG
ACTGGGCAGATCCTCAAGCAGACCTACAGCAAGTTTGACACAAACTCACACAACCATGAC
GCACTGCTCAAGAACTACGGGCTGCTCTACTGCTTCAGGAAGGACATGGACAAGGTCGAG
ACATTCCTGCGCATGGTGCAGTGCCGCTCTGTAGAGGGTAGCTGTGGCTTCTAG

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
V00573

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_6_Locus:
17q24.2

# Macromolecular_Interacting_Partner_6_SNPs:
rs1130686; rs2003779; rs1050840; rs1050850; rs3210093; rs1050857; rs1130670; rs12449537; rs2665811; rs2727350; rs8077960; rs2727354; rs2665812; rs11657340; rs3760244; rs2854162; rs2727341; rs17854931; rs9909776; rs2854169; rs2854168; rs1050899; rs11554677; rs4058030; rs11554678; rs5821406; rs2320012; rs2854164; rs2515650; rs28376621; rs2665813; rs2009894; rs2466962; rs2854176; rs4968670; rs2854177; rs9897356; rs2854180; rs2727342; rs11656867; rs36073948; rs11651912; rs9906202; rs2854179; rs2955249; rs12938562; rs8072148; rs36051159; rs2727353; rs2854178; rs9905526; rs7212781; rs10574205; rs2727301; rs2955234; rs2955245; rs9797221; rs9906063

# Macromolecular_Interacting_Partner_6_General_References:
6208192; 3030680; 6300056; 2744760; 7169009; 593368; 4712450; 5286363; 438159

# Macromolecular_Interacting_Partner_6_References:
11726571; 2951284; 8317626

# Macromolecular_Interacting_Partner_7_ID:
7873

# Macromolecular_Interacting_Partner_7_Name:
Alpha-fetoprotein precursor

# Macromolecular_Interacting_Partner_7_Synonyms:
Alpha-fetoglobulin; Alpha-1- fetoprotein

# Macromolecular_Interacting_Partner_7_Gene_Name:
AFP

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Alphafetoprotein precursor
MKWVESIFLIFLLNFTESRTLHRNEYGIASILDSYQCTAEISLADLATIFFAQFVQEATY
KEVSKMVKDALTAIEKPTGDEQSSGCLENQLPAFLEELCHEKEILEKYGHSDCCSQSEEG
RHNCFLAHKKPTPASIPLFQVPEPVTSCEAYEEDRETFMNKFIYEIARRHPFLYAPTILL
WAARYDKIIPSCCKAENAVECFQTKAATVTKELRESSLLNQHACAVMKNFGTRTFQAITV
TKLSQKFTKVNFTEIQKLVLDVAHVHEHCCRGDVLDCLQDGEKIMSYICSQQDTLSNKIT
ECCKLTTLERGQCIIHAENDEKPEGLSPNLNRFLGDRDFNQFSSGEKNIFLASFVHEYSR
RHPQLAVSVILRVAKGYQELLEKCFQTENPLECQDKGEEELQKYIQESQALAKRSCGLFQ
KLGEYYLQNAFLVAYTKKAPQLTSSELMAITRKMAATAATCCQLSEDKLLACGEGAADII
IGHLCIRHEMTPVNPGVGQCCTSSYANRRPCFSSLVVDETYVPPAFSDDKFIFHKDLCQA
QGVALQTMKQEFLINLVKQKPQITEEQLEAVIADFSGLLEKCCQGQEQEVCFAEEGQKLI
SKTRAALGV

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
68678

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
5.43

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_7_Signals:
1-18

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
553172

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
FETA_HUMAN (P02771)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
AFP

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
AFP

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:317

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>85 bp
ATGAAGTGGGTGGAATCAATTTTTTTAATTTTCCTACTAAATTTTACTGAATCCAGAACA
CTGCATAGAAATGAATATGGAATAG

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
M10949

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_7_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_7_SNPs:
rs7790; rs35765619; rs35920062; rs4235117; rs1894264; rs2298839; rs4235118; rs10002756; rs2070849; rs12506899; rs737241; rs7660680; rs4422394; rs3796678; rs2276937; rs3796676; rs7668327; rs3822100; rs10518114; rs6446933; rs16849384; rs6857080; rs3796677; rs12504308; rs4640638; rs11941100; rs10031441; rs2019898; rs11936954; rs4694166; rs2019897; rs4018; rs10020432; rs6834059; rs4024; rs12651581; rs4446279; rs6815213; rs41265657; rs28482344; rs35924362; rs3198039; rs10594718; rs17182362; rs4444799; rs35125494; rs35252463; rs7667494; rs5859373; rs13102854; rs35201987; rs6446932; rs28693791; rs4694167; rs5020423; rs16849445; rs34255749; rs16849388; rs13108334; rs34058340; rs13149053; rs7655393; rs35853622; rs41265659; rs36011853; rs10015577; rs1981436; rs41265655; rs35797141; rs28532518; rs11725873; rs3930316; rs7667243; rs16849431; rs34322938; rs6826233; rs11363813; rs35788997; rs11737836; rs10001225; rs10027725; rs12510174; rs12649712; rs13123067; rs13123090; rs13138734; rs13150293; rs16849364; rs16849366; rs16849372; rs16849451; rs35151335; rs36110527; rs4403016; rs4498110; rs4575963; rs4602472; rs4632620; rs4694614; rs6446934; rs6446935; rs6829532; rs6850155; rs6853402; rs7686555; rs9784480; rs9784481; rs9996318

# Macromolecular_Interacting_Partner_7_General_References:
6192439; 2436661; 7684942; 6187626; 1709810; 70228; 71198; 4138095; 2580830; 80265; 89900; 2414772

# Macromolecular_Interacting_Partner_7_References:
16764012; 2437689; 8904471

End of HMDB00153

Beginning of HMDB00156
# Accession_No:
HMDB00156

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-23 13:27:04

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
L-Malic acid

# Description:
Malic acid is a tart-tasting organic dicarboxylic acid that plays a role in many sour or tart foods. In its ionized form it is malate, an intermediate of the TCA cycle along with fumarate. It can also be formed from pyruvate as one of the anaplerotic reactions. Apples contain malic acid, which contributes to the sourness of a green apple. Malic acid can make a wine taste tart, although the amount decreases with increasing fruit ripeness. (wikipedia)

# Synonyms:
(-)-(S)-Malate; (-)-(S)-Malic acid; (-)-Hydroxysuccinate; (-)-Hydroxysuccinic acid; (-)-L-Malic acid; (-)-Malic acid; (2S)-2-Hydroxybutanedioate; (2S)-2-Hydroxybutanedioic acid; (S)-(-)-Hydroxysuccinate; (S)-(-)-Hydroxysuccinic acid; (S)-Hydroxybutanedioate; (S)-Hydroxybutanedioic acid; (S)-Malic acid; (S)-hydroxy-Butanedioate; (S)-hydroxy-Butanedioic acid; Apple acid; L-(-)-Malic acid; L-Apple acid; L-Hydroxybutanedioate; L-Hydroxybutanedioic acid; L-Hydroxysuccinate; L-Hydroxysuccinic acid; Malic acid; S-(-)-Malate; S-(-)-Malic acid; S-2-Hydroxybutanedioate; S-2-Hydroxybutanedioic acid

# Chemical_IUPAC_Name:
(2S)-2-hydroxybutanedioic acid

# Chemical_Formula:
C4H6O5

# Chemical_Structure:
tbl_chemical:::HMDB00156_ZOOM.png:::119283222807356891

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00156_THUMB.png:::11928322264756835

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
secondary alcohol; carboxylic acid; alpha-hydroxyacid

# Taxonomy_Biofunction:
Component of Glyoxylate and dicarboxylate metabolism; Component of Pyruvate metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
134.02153

# Molecular_Weight_Avg:
134.08745

# Smiles_String_isomeric:
O[C@@H](CC(O)=O)C(O)=O

# Smiles_String_canonical:
OC(CC(O)=O)C(O)=O

# KEGG_Compound_ID:
C00149

# BioCyc_ID:
Not Available

# PubChem_CID:
222656

# PubChem_SID:
827429; 829568; 6436195; 10322419; 836083; 8145221; 3449; 10318483; 820120; 8026895; 10322572; 835306; 9377165; 828973; 827349; 74751; 8137952; 854569; 829562; 820124; 820118; 584921

# OMIM_ID:
107920; 254960

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Apple acid

# METLIN_ID:
118

# Ref_ID:
8579834; 7982367; 10463437; 8132158; 2026685

# ChEBI_ID:
15589

# CAS_Registry_Number:
97-67-6

# InChI:
InChI=1/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/t2-/m0/s1

# Synthesis_Reference:
J. Chem Society 123, 2875 (1923)

# Melting_Point:
107 oC

# Melting_Point_predicted:
33.8 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
218.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-0.86 [Predicted by ALOGPS]; -1.5 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::L-Malic acid.pdf:::1132562207579396822

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::L-Malic_acid.mol:::1132723810484491716

# SDF_File_[Text]:
tbl_chemical:::HMDB00156.sdf:::119283222337824585

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00156.pdb:::119283222509981564

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:


# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:


# H_NMR_Spectra_Sykes:
tbl_hnmrs:::97-67-6-presat_JM.GIF:::1132883850781609508

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041018_P00_05_HW_1DP_presat.zip:::115204954825616947

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041018_P00_05_HW_1DP_Assigned.png:::116553306780717385

# C_NMR_Spectra:
tbl_cnmr:::041018_P00_05_HW_1DC_90.jpg:::114168459999810417

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041018_P00_05_HW_1DC_90.zip:::114168459997182322

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041018_P00_05_HW_1DC_90_Assigned.jpg:::114332863260317766

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041018_P00_05_HW_2DHSQC_309.jpg:::114608733886421889

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041018_P00_05_HW_2DHSQC_309.zip:::114608733888775279

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041018_P00_05_HW_2DHSQC_309_Assigned.jpg:::11460873390854964

# Predicted_H_NMR_Spectrum:
tbl_chemical:::L-Malic acid.gif:::1132732114859272925

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00156_peaks.txt:::1156309581352673253

# Predicted_C_NMR_Spectrum:
tbl_chemical:::L-Malic acid_C.gif:::1132737702292661882

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00156_peaks.txt:::1156310771133756769

# Mass_Spectrum:
Low Energy:tbl_ms:::Malic acidL.gif:::114721266353930575

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000238.png:::116907445079658257

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000238.txt:::116907445079626566

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000238.png:::116890832495359938

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000238.txt:::116890832520351997

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Cellular Cytoplasm

# Concentration_[Normal]:
Blood	12.0 (0.0-21.0)	umol/L	Adult:>18_yrs_old	Both	Normal	8412012
Blood	3.2 +/- 0.9	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	3.0 +/- 3.0 	uM	Adult:>18_yrs_old	Both	Normal	8412012
Cellular_Cytoplasm	3200 (2800-3600)	umol/L	Adult:>18_yrs_old	Both	Normal	8579834


# Concentration_[Abnormal]:
Cellular_Cytoplasm	480 (470-490)	umol/L	Adult:>18_yrs_old	Both	Anoxia	8579834


# Associated_Disorders:
Anoxia

# Pathway_Names:
Pyruvate metabolism;Glyoxylate and dicarboxylate metabolism;Reductive carboxylate cycle (CO2 fixation)

# Pathway_Images:
;;

# KEGG_Images:
map00620;map00630;map00720

# Pathway_Graphs:
;;

# Pathway_SBMLs:
;;

# Metabolic_Enzyme_1_ID:
6138

# Metabolic_Enzyme_1_Name:
NADP-dependent malic enzyme

# Metabolic_Enzyme_1_Synonyms:
NADP-ME; Malic enzyme 1

# Metabolic_Enzyme_1_Gene_Name:
ME1

# Metabolic_Enzyme_1_Protein_Sequence:
>NADPdependent malic enzyme
MEPEAPRRRHTHQRGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVK
NFEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKP
RGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTAC
GGMNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNC
LIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTILFQ
GAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIVKGRASLTQEKEKFAHEHEE
MKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECSAEQC
YKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVALGVVACGLRQITDNIFLT
TAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAFV
RSQMYSTDYDQILPDCYSWPEEVQKIQTKVDQ

# Metabolic_Enzyme_1_Number_of_Residues:
572

# Metabolic_Enzyme_1_Molecular_Weight:
64150

# Metabolic_Enzyme_1_Theoretical_pI:
6.01

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  malate dehydrogenase activity
Function:  malic enzyme activity
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  malate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH

# Metabolic_Enzyme_1_Pathway:
map00620  Pyruvate metabolism;
 map00710  Carbon fixation

# Metabolic_Enzyme_1_Reaction:
(S)-malate + NADP+ = pyruvate + CO2 + NADPH

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00390:malic;
PF03949:Malic_M

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.1.1.40

# Metabolic_Enzyme_1_GenBank_ID_Protein:
495123

# Metabolic_Enzyme_1_SwissProt_ID:
MAOX_HUMAN (P48163)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ME1

# Metabolic_Enzyme_1_Geneatlas_id:
ME1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:6983

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1719 bp
ATGGAGCCCGAAGCCCCCCGTCGCCGCCACACCCATCAGCGCGGCTACCTGCTGACACGG
AACCCTCACCTCAACAAGGACTTGGCCTTTACCCTGGAAGAGAGACAGCAATTGAACATT
CATGGATTGTTGCCACCTTCCTTCAACAGTCAGGAGATCCAGGTTCTTAGAGTAGTAAAA
AATTTCGAGCATCTGAACTCTGACTTTGACAGGTATCTTCTCTTAATGGATCTCCAAGAT
AGAAATGAAAAACTCTTTTATAGAGTGCTGACATCTGACATTGAGAAATTCATGCCTATT
GTTTATACTCCCACTGTGGGTCTGGCTTGCCAACAATATAGTTTGGTGTTTCGGAAGCCA
AGAGGTCTCTTTATTACTATCCACGATCGAGGGCATATTGCTTCAGTTCTCAATGCATGG
CCAGAAGATGTCATCAAGGCCATTGTGGTGACTGATGGAGAGCGTATTCTTGGCTTGGGA
GACCTTGGCTGTAATGGAATGGGCATCCCTGTGGGTAAATTGGCTCTATATACAGCTTGC
GGAGGGATGAATCCTCAAGAATGTCTGCCTGTCATTCTGGATGTGGGAACCGAAAATGAG
GAGTTACTTAAAGATCCACTCTACATTGGACTACGGCAGAGAAGAGTAAGAGGTTCTGAA
TATGATGATTTTTTGGACGAATTCATGGAGGCAGTTTCTTCCAAGTATGGCATGAATTGC
CTTATTCAGTTTGAAGATTTTGCCAATGTGAATGCATTTCGTCTCCTGAACAAGTATCGA
AACCAGTATTGCACATTCAATGATGATATTCAAGGAACAGCATCTGTTGCAGTTGCAGGT
CTCCTTGCAGCTCTTCGAATAACCAAGAACAAACTGTCTGATCAAACAATACTATTCCAA
GGAGCTGGAGAGGCTGCCCTAGGGATTGCACACCTGATTGTGATGGCCTTGGAAAAAGAA
GGTTTACCAAAAGAGAAAGCCATCAAAAAGATATGGCTGGTTGATTCAAAAGGATTAATA
GTTAAGGGACGTGCTTCCTTAACACAAGAGAAAGAGAAGTTTGCCCATGAACATGAAGAA
ATGAAGAACCTAGAAGCCATTGTTCAAGAAATAAAACCAACTGCCCTCATAGGAGTTGCT
GCAATTGGTGGTGCATTCTCAGAACAAATTCTCAAAGATATGGCTGCCTTCAATGAACGG
CCTATTATTTTTGCTTTGAGTAATCCAACTAGCAAAGCAGAATGTTCTGCAGAGCAGTGC
TACAAAATAACCAAGGGACGTGCAATTTTTGCCAGTGGCAGTCCTTTTGATCCAGTCACT
CTTCCAAATGGACAGACCCTATATCCTGGCCAAGGCAACAATTCCTACGTGTTCCCTGGA
GTTGCTCTTGGTGTTGTGGCGTGTGGATTGAGGCAGATCACAGATAATATTTTCCTCACT
ACTGCTGAGGTTATAGCTCAGCAAGTGTCAGATAAACACTTGGAAGAGGGTCGGCTTTAT
CCTCCTTTGAATACCATTAGAGATGTTTCTCTGAAAATTGCAGAAAAGATTGTGAAAGAT
GCATACCAAGAAAAGACAGCCACAGTTTATCCTGAACCGCAAAACAAAGAAGCATTTGTC
CGCTCCCAGATGTATAGTACTGATTATGACCAGATTCTACCTGATTGTTATTCTTGGCCT
GAAGAGGTGCAGAAAATACAGACCAAAGTTGACCAGTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X77244

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_1_Locus:
6q12

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
8187880; 7622060; 14574404; 8804575

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6139

# Metabolic_Enzyme_2_Name:
Malate dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_2_Synonyms:
Not Available

# Metabolic_Enzyme_2_Gene_Name:
MDH2

# Metabolic_Enzyme_2_Protein_Sequence:
>Malate dehydrogenase, mitochondrial precursor
MLSALARPVSAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAH
TPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATI
VATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTF
VAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKA
KAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIE
KNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK

# Metabolic_Enzyme_2_Number_of_Residues:
338

# Metabolic_Enzyme_2_Molecular_Weight:
35532

# Metabolic_Enzyme_2_Theoretical_pI:
8.90

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  L-malate dehydrogenase activity
Function:  malate dehydrogenase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
Process:  malate metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
(S)-malate + NAD(+) = oxaloacetate + NADH

# Metabolic_Enzyme_2_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00620  Pyruvate metabolism;
 map00630  Glyoxylate and dicarboxylate metabolism;
 map00710  Carbon fixation;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_2_Reaction:
(S)-malate + NAD+ = oxaloacetate + NADH + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF02866:Ldh_1_C;
PF00056:Ldh_1_N

# Metabolic_Enzyme_2_Signals:
1-11

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.1.37

# Metabolic_Enzyme_2_GenBank_ID_Protein:
2906146

# Metabolic_Enzyme_2_SwissProt_ID:
MDHM_HUMAN (P40926)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
MDH2

# Metabolic_Enzyme_2_Geneatlas_id:
MDH2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:6971

# Metabolic_Enzyme_2_PDB_ID:
1MLD

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_2_Gene_Sequence:
>1017 bp
ATGCTCTCCGCCCTCGCCCGGCCTGTCAGCGCTGCTCTCCGCCGCAGCTTCAGCACCTCA
GCCCAGAACAATGCTAAAGTAGCTGTGCTAGGGGCCTCTGGAGGCATCGGGCAGCCACTT
TCACTTCTCCTGAAGAACAGCCCCTTGGTGAGCCGCCTGACCCTCTATGATATCGCGCAC
ACACCCGGAGTGGCCGCAGATCTGAGCCACATCGAGACCAAAGCCGCTGTGAAAGGCTAC
CTCGGACCTGAACAGCTGCCTGACTGCCTGAAAGGTTGTGATGTGGTAGTTATTCCGGCT
GGAGTCCCCAGAAAGCCAGGCATGACCCGGGACGACCTGTTCAACACCAATGCCACGATT
GTGGCCACCCTGACCGCTGCCTGTGCCCAGCACTGCCCGGAAGCCATGATCTGCGTCATT
GCCAATCCGGTTAATTCCACCATCCCCATCACAGCAGAAGTTTTCAAGAAGCATGGAGTG
TACAACCCCAACAAAATCTTCGGCGTGACGACCCTGGACATCGTCAGAGCCAACACCTTT
GTTGCAGAGCTGAAGGGTTTGGATCCAGCTCGAGTCAACGTCCCTGTCATTGGTGGCCAT
GCTGGGAAGACCATCATCCCCCTGATCTCTCAGTGCACCCCCAAGGTGGACTTTCCCCAG
GACCAGCTGACAGCACTCACTGGGCGGATCCAGGAGGCCGGCACGGAGGTGGTCAAGGCT
AAAGCCGGAGCAGGCTCTGCCACCCTCTCCATGGCGTATGCCGGCGCCCGCTTTGTCTTC
TCCCTTGTGGATGCAATGAATGGAAAGGAAGGTGTTGTGGAATGTTCCTTCGTTAAGTCA
CAGGAAACGGAATGTACCTACTTCTCCACACCGCTGCTGCTTGGGAAAAAGGGCATCGAG
AAGAACCTGGGCATCGGCAAAGTCTCCTCTTTTGAGGAGAAGATGATCTCGGATGCCATC
CCCGAGCTGAAGGCCTCCATCAAGAAGGGGGAAGATTTCGTGAAGACCCTGAAGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF047470

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_2_Locus:
7p12.3-q11.2

# Metabolic_Enzyme_2_SNPs:
rs3178297; rs3815457; rs1104879; rs869806; rs1104878; rs6964005; rs1637039; rs869805; rs869804; rs2286830; rs11972240; rs1637037; rs1639609; rs12670046; rs1465293; rs1465296; rs3779419; rs3779421; rs1540353; rs963759; rs7786630; rs867973; rs1637028; rs1637033; rs2868203; rs1637027; rs6950085; rs3757592; rs6976532; rs13236824; rs1637029; rs10476; rs3801471; rs1639614; rs11538802; rs11538799; rs1133086; rs35052186; rs34519552; rs35314447; rs35280599; rs887576; rs11764853; rs2069307; rs1639610; rs35269136; rs10251030; rs35230518; rs3779420; rs6467989; rs11342333; rs34267002; rs1574107; rs3214335; rs7793822; rs1630434; rs6949043; rs6964165; rs1465295; rs10250810; rs3757591; rs1637030; rs35653270; rs10216079; rs34603671; rs1465294; rs6976174; rs1054336; rs11761014; rs1637045; rs1639620; rs17849553; rs2302437; rs4470977; rs4728551; rs4728552; rs8200; rs887578; rs887579

# Metabolic_Enzyme_2_General_References:
Not Available

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6140

# Metabolic_Enzyme_3_Name:
NADP-dependent malic enzyme, mitochondrial precursor

# Metabolic_Enzyme_3_Synonyms:
NADP-ME; Malic enzyme 3

# Metabolic_Enzyme_3_Gene_Name:
ME3

# Metabolic_Enzyme_3_Protein_Sequence:
>NADPdependent malic enzyme, mitochondrial precursor
MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLN
KGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKL
FYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNI
KAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRD
PLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCM
FNDDIQGTASVAVAGILAALRITNNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKA
EATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGA
FTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGK
TFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLST
IRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMN
VQTV

# Metabolic_Enzyme_3_Number_of_Residues:
604

# Metabolic_Enzyme_3_Molecular_Weight:
67055

# Metabolic_Enzyme_3_Theoretical_pI:
7.92

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  malate dehydrogenase activity
Function:  malic enzyme activity
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  malate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH

# Metabolic_Enzyme_3_Pathway:
map00620  Pyruvate metabolism;
 map00710  Carbon fixation

# Metabolic_Enzyme_3_Reaction:
(S)-malate + NADP+ = pyruvate + CO2 + NADPH

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00390:malic;
PF03949:Malic_M

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.1.1.40

# Metabolic_Enzyme_3_GenBank_ID_Protein:
535012

# Metabolic_Enzyme_3_SwissProt_ID:
MAON_HUMAN (Q16798)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ME3

# Metabolic_Enzyme_3_Geneatlas_id:
ME3

# Metabolic_Enzyme_3_hgnc_id:
HGNC:6985

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_3_Gene_Sequence:
>1815 bp
ATGGGTGCCGCGCTGGGGACAGGCACGCGGCTGGCTCCCTGGCCGGGCCGGGCCTGCGGC
GCCCTCCCGCGCTGGACACCCACCGCGCCCGCCCAAGGCTGCCACTCCAAGCCTGGCCCG
GCGCGCCCTGTGCCCCTGAAGAAGCGCGGATACGATGTCACCAGGAACCCTCATCTCAAC
AAGGGGATGGCCTTTACCCTTGAAGAAAGGCTGCAGCTTGGAATCCACGGCCTAATCCCG
CCCTGCTTTCTGAGCCAGGACGTCCAGCTCCTCCGAATCATGAGATATTACGAGCGGCAG
CAGAGTGACCTGGACAAGTACATCATTCTCATGACACTCCAAGACCGGAACGAGAAGCTC
TTCTACCGAGTGCTGACTTCGGATGTGGAGAAGTTCATGCCAATCGTGTACACGCCTACC
GTGGGGCTGGCCTGTCAGCACTATGGCCTGACTTTCCGCAGGCCCCGTGGACTGTTCATC
ACCATTCATGACAAAGGTCATCTTGCAACAATGCTGAATTCTTGGCCAGAAGACAATATT
AAGGCCGTGGTGGTGACTGATGGGGAGCGCATCCTGGGCCTGGGAGACCTGGGCTGCTAC
GGCATGGGCATCCCTGTGGGCAAGCTGGCCCTGTACACGGCATGCGGAGGGGTGAACCCG
CAGCAGTGCCTCCCTGTGCTGCTGGACGTCGGCACCAACAATGAGGAGCTGCTCAGAGAC
CCTCTGTACATCGGCCTGAAACACCAGCGCGTGCACGGGAAGGCATACGATGACTTGCTG
GATGAGTTCATGCAGGCTGTGACAGACAAGTTTGGAATAAATTGCCTCATCCAATTTGAA
GACTTCGCCAATGCCAATGCCTTCCGCCTGCTCAACAAATACCGTAACAAGTACTGCATG
TTCAATGATGACATCCAAGGCACAGCCTCCGTTGCTGTGGCAGGGATCTTGGCTGCTCTG
CGAATCACCAACAACAAGCTTTCCAATCACGTGTTTGTTTTCCAAGGTGCAGGCGAGGCA
GCTATGGGCATTGCCCACCTCCTTGTCATGGCCCTAGAGAAAGAAGGTGTACCGAAGGCA
GAGGCCACAAGAAAGATCTGGATGGTGGACTCTAAAGGGCTCATTGTCAAGGGGAGGAGC
CACCTGAACCATGAAAAGGAGATGTTTGCCCAAGACCATCCTGAAGTCAACTCCCTGGAG
GAGGTGGTGAGGCTGGTGAAGCCCACAGCCATCATAGGTGTTGCTGCCATCGCAGGAGCC
TTCACGGAGCAGATTCTGAGGGACATGGCCTCCTTCCACGAGCGCCCTATCATCTTTGCC
CTGAGCAACCCCACCAGCAAGGCCGAGTGCACGGCTGAGAAGTGCTACCGGGTCACCGAG
GGCCGAGGGATTTTTGCCAGTGGAAGTCCTTTTAAGAGTGTGACTCTGGAAGATGGCAAG
ACCTTCATTCCTGGGCAGGGAAACAATGCTTACGTGTTCCCCGGGGTGGCACTGGGAGTC
ATCGCCGGCGGGATCCGGCACATCCCAGATGAGATCTTCCTCCTGACAGCAGAGCAAATT
GCCCAGGAAGTCTCTGAGCAGCATCTGTCCCAGGGGAGACTCTATCCACCACTCAGCACC
ATCCGAGACGTGTCTTTGAGAATTGCCATCAAAGTTCTCGACTACGCGTACAAACACAAC
CTGGCTTCCTACTACCCAGAGCCTAAGGACAAGGAGGCTTTTGTAAGATCCCTGGTCTAC
ACTCCAGACTATGACTCCTTTACACTGGACAGCTACACTTGGCCCAAGGAAGCCATGAAT
GTTCAGACGGTCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X79440

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_3_Locus:
11cen-q22.3

# Metabolic_Enzyme_3_SNPs:
rs1042780; rs4943943; rs17211115; rs7946487; rs12287767; rs34662182; rs2446230; rs1945034; rs632873; rs1541310; rs675775; rs677643; rs1541309; rs722158; rs1540082; rs1938921; rs1945142; rs659405; rs2051434; rs624183; rs553351; rs666472; rs587362; rs498981; rs1894012; rs618513; rs539805; rs1938935; rs2226566; rs663262; rs660372; rs679220; rs1938924; rs623478; rs525764; rs632538; rs2511090; rs681333; rs647561; rs658166; rs643414; rs609848; rs2156532; rs634509; rs1458382; rs999472; rs2078385; rs2446228; rs668753; rs601646; rs949349; rs1938931; rs582282; rs1938938; rs651089; rs1945036; rs611156; rs2032356; rs722157; rs622933; rs1938923; rs1938926; rs661163; rs601824; rs616018; rs679076; rs633708; rs538058; rs1841066; rs539939; rs590401; rs4319536; rs4944580; rs7123773; rs655934; rs7950878; rs3819227; rs10219305; rs10898524; rs7109270; rs10219173; rs3824954; rs672526; rs10898501; rs651758; rs609885; rs502749; rs949351; rs7948981; rs10792860; rs7120052; rs1945143; rs7120444; rs7940192; rs4944602; rs4439535; rs7951868; rs6592301; rs10898498; rs626049; rs2279046; rs7112309; rs4144867; rs625925; rs687804; rs493010; rs7122296; rs11607733; rs7940187; rs2446229; rs4944612; rs10898483; rs10898514; rs11234656; rs1945043; rs4944607; rs12285249; rs606546; rs601988; rs1542426; rs585218; rs7117375; rs10444375; rs1938928; rs4943949; rs2051433; rs6592296; rs4405344; rs6592295; rs10792865; rs10792866; rs7103271; rs11234707; rs7941337; rs2446225; rs658324; rs10219319; rs7937853; rs7109521; rs7105863; rs4944613; rs630438; rs7122406; rs4144866; rs2242142; rs7943741; rs1938927; rs10792861; rs638041; rs7940549; rs624843; rs7940654; rs7117234; rs7122928; rs12282010; rs7940523; rs10501627; rs10898484; rs4944596; rs7122479; rs7108055; rs669325; rs7941446; rs4382935; rs7949910; rs12417575; rs7108746; rs4944604; rs12361283; rs4592448; rs7925862; rs662361; rs588287; rs1540083; rs668272; rs6592294; rs4944609; rs7103017; rs611730; rs507123; rs7109853; rs1945145; rs7127944; rs636485; rs1006586; rs677700; rs9787905; rs7122239; rs4944592; rs585749; rs603241; rs1938929; rs2125363; rs601300; rs7106865; rs1458384; rs147045; rs949350; rs4382934; rs7935611; rs1938932; rs4944611; rs4144865; rs630454; rs10501625; rs2511082; rs1945146; rs657378; rs584953; rs7119775; rs605251; rs7116278; rs3758877; rs10898490; rs616794; rs12284853; rs1379872; rs12576144; rs10792854; rs7951185; rs4944593; rs1563682; rs7940587; rs676106; rs10898512; rs10792858; rs12575285; rs7940772; rs579719; rs11819827; rs612163; rs507211; rs7940781; rs11828425; rs12290684; rs6592297; rs10501621; rs7938505; rs659301; rs4245422; rs10792864; rs2168862; rs11825033; rs7117702; rs621653; rs7126717; rs503583; rs10219378; rs4245423; rs10501624; rs17149147; rs11606017; rs3781812; rs7937668; rs638492; rs11234691; rs4944600; rs672266; rs646691; rs613412; rs11826066; rs661328; rs631082; rs7115580; rs10898488; rs598187; rs635934; rs679382; rs10792857; rs4405345; rs10501620; rs10501628; rs628406; rs7930619; rs2279047; rs1945144; rs7118187; rs17819683; rs668270; rs597793; rs7944874; rs17149169; rs4944603; rs10444372; rs635637; rs12797615; rs683899; rs4245420; rs3781813; rs663208; rs647782; rs6592302; rs12804997; rs661954; rs10792856; rs10898515; rs10501623; rs7123010; rs4943945; rs7103556; rs591060; rs653715; rs4245418; rs7934133; rs17211577; rs7125366; rs11234702; rs17211570; rs2155035; rs610790; rs7126810; rs4944614; rs17149234; rs12289252; rs7130920; rs2840368; rs1006587; rs12420965; rs4245424; rs608180; rs561363; rs17819176; rs7940788; rs640310; rs1870323; rs2125362; rs11234662; rs4944610; rs10792855; rs679977; rs10501622; rs585527; rs597296; rs7940590; rs664613; rs7928552; rs10898500; rs593853; rs11821546; rs11234708; rs10792862; rs17149180; rs614995; rs11234719; rs17819523; rs767776; rs1458381; rs4944581; rs2279048; rs7102806; rs2446224; rs583594; rs10898496; rs10898516; rs10501626; rs4245421; rs624236; rs7115834; rs641541; rs10898485; rs10400291; rs10792863; rs17159928; rs11234658; rs7107136; rs1938922; rs7123044; rs12285344; rs677301; rs7941124; rs4245419; rs4944586; rs12281596; rs624870; rs7940448; rs9705039; rs1938925; rs12293809; rs17757676; rs2446226; rs11234676; rs7121583; rs11606042; rs9667152; rs2032355; rs9704409; rs11234731; rs589368; rs10898499; rs11234700; rs7930715; rs687138; rs3889658; rs628449; rs7925379; rs7924879; rs7103642; rs12801189; rs637693; rs12365092; rs531908; rs7949920; rs11234657; rs17818784; rs11234711; rs10898517; rs11234716; rs17211409; rs11234678; rs10444374; rs9645702; rs7128131; rs7116895; rs12798729; rs10898494; rs7130902; rs10898505; rs674250; rs11234683; rs17149242; rs12805940; rs4944616; rs11234729; rs11604162; rs11820663; rs10898507; rs642780; rs7941051; rs619195; rs535652; rs668984; rs11234704; rs7945440; rs969034; rs12291729; rs589174; rs681158; rs11234692; rs12419111; rs2125358; rs3824952; rs12573953; rs7480835; rs12365653; rs566633; rs7125970; rs10898508; rs12269800; rs4245417; rs648798; rs7108710; rs9667168; rs1938918; rs4944585; rs1824279; rs1945139; rs12792674; rs748102; rs12793144; rs12421147; rs7944836; rs590750; rs501362; rs7938344; rs11821635; rs674481; rs10444371; rs12419781; rs17211458; rs12574128; rs4944617; rs643950; rs10792871; rs7104141; rs12283397; rs11234665; rs4944595; rs9943610; rs12285306; rs7945240; rs7938901; rs11234701; rs4943946; rs7952019; rs10898513; rs9645703; rs1945138; rs17211053; rs7943403; rs2155033; rs2212341; rs7938741; rs11828773; rs17818845; rs682501; rs12808738; rs11602862; rs627684; rs4944594; rs12799562; rs1458383; rs11234715; rs9667489; rs10898502; rs1541308; rs1540081; rs12793707; rs7941576; rs10898518; rs2276394; rs511884; rs7926965; rs12364541; rs10898509; rs11234713; rs9667156; rs11234705; rs530278; rs4944587; rs644086; rs11234690; rs11234718; rs1350478; rs539214; rs4944582; rs12277137; rs11606745; rs2212340; rs12222139; rs673118; rs7945260; rs3824953; rs688079; rs12361416; rs12362293; rs661115; rs7948764; rs17149223; rs12420485; rs11234727; rs11234689; rs9943508; rs12804208; rs7935437; rs10898495; rs584068; rs503195; rs4944583; rs7927467; rs593450; rs12224723; rs17149245; rs10898510; rs2511083; rs11607554; rs594106; rs1938920; rs9667775; rs12797575; rs7930401; rs546427; rs4291698; rs11234686; rs12790474; rs4391846; rs11234699; rs1945137; rs10898503; rs11234714; rs7940800; rs12799435; rs7119485; rs4943955; rs12285279; rs2017483; rs7117143; rs12793198; rs7946685; rs7109555; rs7927796; rs11234726; rs998872; rs2446227; rs638135; rs17149197; rs12792300; rs670602; rs596056; rs7930654; rs3758878; rs480290; rs12226269; rs4944597; rs610476; rs2511081; rs751911; rs1938919; rs4944622; rs12288119; rs11602628; rs12280733; rs11234712; rs1945141; rs10898506; rs660893; rs9943611; rs17211563; rs7105382; rs12269985; rs17211584; rs605618; rs10792868; rs694952; rs12575580; rs17149130; rs17149226; rs1945035; rs610842; rs10898493; rs10898504; rs582976; rs7927795; rs12274942; rs17149238; rs10898511; rs653313; rs4943948; rs670736; rs1452138; rs684365; rs1452137; rs1452136; rs4943940; rs589887; rs12283035; rs4944578; rs11823255; rs12294756; rs682915; rs547591; rs7926796; rs12281645; rs10898525; rs35245729; rs3182235; rs15926; rs17852036; rs17845700; rs17856661; rs11556735; rs35059554; rs1062639; rs987649; rs685439; rs656307; rs5793201; rs646798; rs7924919; rs34470258; rs693052; rs12574675; rs7939530; rs11355612; rs11234687; rs34652301; rs618843; rs28895937; rs11518769; rs515798; rs3781806; rs12271274; rs11234668; rs36139518; rs11234673; rs9667498; rs12294332; rs2511089; rs623785; rs4483612; rs654286; rs496167; rs3862787; rs1902958; rs672264; rs34131458; rs12805450; rs582886; rs34631227; rs661972; rs7124538; rs35941464; rs11559614; rs1791443; rs11234709; rs10618233; rs7118346; rs12273697; rs9735826; rs34382146; rs10559080; rs12271571; rs659700; rs34909419; rs11234697; rs34838255; rs11383258; rs672280; rs10545624; rs680846; rs35804280; rs11459186; rs11234720; rs11359686; rs35420773; rs661083; rs4500512; rs12283825; rs28837406; rs34095490; rs12795419; rs618384; rs605255; rs11276982; rs4944620; rs28804208; rs10652368; rs1619882; rs34416639; rs2125360; rs2510498; rs35621612; rs34691357; rs4943952; rs34939684; rs7122008; rs11821842; rs12282012; rs12575681; rs12787395; rs11308452; rs11535845; rs11602146; rs7122667; rs34300602; rs35429348; rs658509; rs550761; rs34659727; rs35175493; rs35291772; rs12794991; rs597823; rs34754668; rs5793204; rs591474; rs10636674; rs657580; rs12362471; rs34832707; rs34557852; rs34946099; rs35892534; rs12294331; rs28603177; rs34313794; rs2219430; rs7934775; rs35187445; rs11234669; rs7929523; rs5793202; rs11601960; rs615371; rs34220027; rs34900435; rs34557683; rs2446231; rs11494278; rs11512936; rs35947577; rs3837399; rs9634021; rs3894263; rs11387187; rs10569902; rs6144422; rs12575999; rs5793205; rs12279297; rs11234664; rs12271552; rs28799720; rs4944590; rs34027067; rs35731805; rs11234696; rs35019870; rs602923; rs686768; rs643072; rs9667181; rs28678569; rs11369958; rs663543; rs12785372; rs4944588; rs11366218; rs2156531; rs11234660; rs12271548; rs34265019; rs604299; rs36152939; rs34764333; rs34278824; rs11392522; rs504635; rs12788873; rs17149146; rs2511085; rs4944579; rs34725712; rs11234721; rs35651342; rs642278; rs663073; rs11560984; rs12292032; rs7103785; rs12788651; rs1938934; rs28446263; rs35122148; rs11828585; rs10676754; rs11271121; rs2852378; rs34224480; rs683408; rs595031; rs11234677; rs617962; rs35557705; rs12269737; rs35393888; rs12417744; rs4943942; rs28825102; rs12804283; rs12804130; rs10672954; rs9705154; rs670825; rs12280101; rs35129724; rs12146569; rs28494065; rs4462374; rs35905440; rs471780; rs11512882; rs12271549; rs11532101; rs7115594; rs11530882; rs4944601; rs2511084; rs11234661; rs2305928; rs35463445; rs635971; rs36152806; rs7107161; rs34988004; rs34080694; rs34877706; rs35748086; rs36124549; rs12280500; rs34887500; rs34028266; rs5793206; rs2226858; rs34061130; rs12222903; rs34405620; rs3045014; rs35163253; rs12805420; rs1235409; rs35546812; rs7939052; rs11530863; rs12293152; rs11302044; rs12794525; rs604128; rs10601910; rs12804026; rs34349106; rs503155; rs34258229; rs653779; rs11512938; rs11234666; rs34699198; rs12291889; rs12362900; rs11234733; rs687669; rs28609643; rs10698015; rs12806468; rs10579155; rs642728; rs7112251; rs28583010; rs4943954; rs11533267; rs12791972; rs28716504; rs35269702; rs35968408; rs10653582; rs34393952; rs11501849; rs11234670; rs34996965; rs11234722; rs596322; rs10652369; rs5793209; rs7102548; rs487960; rs4944618; rs689039; rs34103747; rs12792567; rs34573490; rs12278573; rs35677637; rs34782520; rs12786394; rs10659565; rs34796489; rs4943941; rs35635737; rs12787475; rs10579052; rs35359440; rs627383; rs5793198; rs35222052; rs34315700; rs28452300; rs609855; rs11512934; rs4122041; rs503923; rs581796; rs11561000; rs629038; rs11234685; rs2511086; rs35870909; rs2105784; rs752519; rs12288171; rs679731; rs659781; rs33973657; rs4943950; rs35899335; rs12803885; rs12276356; rs10538002; rs34930310; rs11530862; rs12804089; rs7117530; rs2276393; rs1007948; rs3781808; rs34514194; rs36071853; rs34544991; rs10675389; rs12280100; rs10444373; rs12291626; rs35352939; rs582638; rs11603205; rs661831; rs11234706; rs10559079; rs4471455; rs34334006; rs1060779; rs35625263; rs503949; rs28865371; rs28850038; rs11234667; rs4614483; rs36030892; rs36014844; rs747227; rs11388635; rs28605742; rs35377581; rs7115713; rs619472; rs7124121; rs36012184; rs35255565; rs34698065; rs35650693; rs11234672; rs12805421; rs620054; rs11518768; rs11824279; rs11442101; rs35831878; rs35439198; rs28824521; rs35676005; rs11234730; rs4553393; rs12280255; rs11518770; rs648726; rs5793200; rs5793207; rs12804407; rs35754183; rs34677719; rs34493285; rs619829; rs11234671; rs11501724; rs883190; rs688119; rs648258; rs663627; rs12417361; rs11234717; rs7484000; rs11234688; rs12272130; rs28803287; rs35723009; rs35942916; rs3216158; rs12805438; rs35042210; rs7111906; rs11537258; rs2511080; rs10539253; rs35030247; rs11501841; rs4291697; rs35061999; rs5793199; rs603890; rs1612079; rs35686713; rs35722020; rs35636838; rs12805566; rs10160338; rs11234684; rs35072041; rs34920485; rs2125361; rs11234698; rs1938937; rs509870; rs35086246; rs34385651; rs34267395; rs11305226; rs34371898; rs637758; rs5793203; rs550168; rs11494275; rs34952173; rs11402713; rs561237; rs11234703; rs36107930; rs35726265; rs34433932; rs613418; rs12792072; rs35180248; rs10751139; rs12222272; rs655868; rs34237389; rs34730962; rs34249558; rs12098937; rs36078024; rs35193618; rs10583492; rs35420443; rs34837662; rs34902539; rs11234652; rs11607319; rs11828146; rs12270761; rs12276248; rs12293159; rs1452133; rs1938936; rs2034622; rs2051435; rs2051436; rs2051437; rs2051438; rs3741004; rs4393345; rs516066; rs516746; rs567615; rs571006; rs594361; rs615858; rs642245; rs643157; rs674053; rs693817

# Metabolic_Enzyme_3_General_References:
7818469

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
6141

# Metabolic_Enzyme_4_Name:
Malate dehydrogenase, cytoplasmic

# Metabolic_Enzyme_4_Synonyms:
Cytosolic malate dehydrogenase

# Metabolic_Enzyme_4_Gene_Name:
MDH1

# Metabolic_Enzyme_4_Protein_Sequence:
>Malate dehydrogenase, cytoplasmic
MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDC
ALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYA
KKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKN
VIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKL
SSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFV
EGLPINDFSREKMDLTAKELTEEKESAFEFLSSA

# Metabolic_Enzyme_4_Number_of_Residues:
334

# Metabolic_Enzyme_4_Molecular_Weight:
36426

# Metabolic_Enzyme_4_Theoretical_pI:
7.45

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  L-malate dehydrogenase activity
Function:  malate dehydrogenase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
Process:  malate metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
(S)-malate + NAD(+) = oxaloacetate + NADH

# Metabolic_Enzyme_4_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00620  Pyruvate metabolism;
 map00630  Glyoxylate and dicarboxylate metabolism;
 map00710  Carbon fixation;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_4_Reaction:
(S)-malate + NAD+ = oxaloacetate + NADH + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF02866:Ldh_1_C;
PF00056:Ldh_1_N

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.1.1.37

# Metabolic_Enzyme_4_GenBank_ID_Protein:
1255604

# Metabolic_Enzyme_4_SwissProt_ID:
MDHC_HUMAN (P40925)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
MDH1

# Metabolic_Enzyme_4_Geneatlas_id:
MDH1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:6970

# Metabolic_Enzyme_4_PDB_ID:
5MDH

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_4_Gene_Sequence:
>1005 bp
ATGTCTGAACCAATCAGAGTCCTTGTGACTGGAGCAGCTGGTCAAATTGCATATTCACTG
CTGTACAGTATTGGAAATGGATCTGTCTTTGGTAAAGATCAGCCTATAATTCTTGTGCTG
TTGGATATCACCCCCATGATGGGTGTCCTGGACGGTGTCCTAATGGAACTGCAAGACTGT
GCCCTTCCCCTCCTGAAAGATGTCATCGCAACAGATAAAGAAGACGTTGCCTTCAAAGAC
CTGGATGTGGCCATTCTTGTGGGCTCCATGCCAAGAAGGGAAGGCATGGAGAGAAAAGAT
TTACTGAAAGCAAATGTGAAAATCTTCAAATCCCAGGGTGCAGCCTTAGATAAATACGCC
AAGAAGTCAGTTAAGGTTATTGTTGTGGGTAATCCAGCCAATACCAACTGCCTGACTGCT
TCCAAGTCAGCTCCATCCATCCCCAAGGAGAACTTCAGTTGCTTGACTCGTTTGGATCAC
AACCGAGCTAAAGCTCAAATTGCTCTTAAACTTGGTGTGACTGCTAATGATGTAAAGAAT
GTCATTATCTGGGGAAACCATTCCTCGACTCAGTATCCAGATGTCAACCATGCCAAGGTG
AAATTGCAAGGAAAGGAAGTTGGTGTTTATGAAGCTCTGAAAGATGACAGCTGGCTCAAG
GGAGAATTTGTCACGACTGTGCAGCAGCGTGGCGCTGCTGTCATCAAGGCTCGAAAACTA
TCCAGTGCCATGTCTGCTGCAAAAGCCATCTGTGACCACGTCAGGGACATCTGGTTTGGA
ACCCCAGAGGGAGAGTTTGTGTCCATGGGTGTTATCTCTGATGGCAACTCCTATGGTGTT
CCTGATGATCTGCTCTACTCATTCCCTGTTGTAATCAAGAATAAGACCTGGAAGTTTGTT
GAAGGTCTCCCTATTAATGATTTCTCACGTGAGAAGATGGATCTTACTGCAAAGGAACTG
ACAGAAGAAAAAGAAAGTGCTTTTGAATTTCTTTCCTCTGCCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
D55654

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_4_Locus:
2p13.3

# Metabolic_Enzyme_4_SNPs:
rs17028056; rs262472; rs1446569; rs10202649; rs9309355; rs11125979; rs7606045; rs10200146; rs262473; rs262471; rs17618390; rs1255; rs262470; rs13419067; rs2604613; rs2305157; rs964880; rs7591566; rs11555100; rs14777; rs11555102; rs3209597; rs11555104; rs11555101; rs1802753; rs12622874; rs34402674; rs34038003; rs34634988; rs7606617; rs41284839; rs11297982; rs34791099; rs3752740; rs3768678; rs34177697; rs13406158; rs4671519; rs4671518; rs10865341; rs35082115; rs34641495; rs10173604; rs2121351; rs9989753; rs10865340; rs35988794; rs12104443; rs35524564; rs7592596; rs4671069; rs36004139; rs262474; rs35873003; rs10469944; rs10469945; rs1109027; rs13025452; rs13411288; rs17618239; rs2028884; rs2278718; rs262490; rs262491; rs3754540; rs6546018; rs6546019; rs6737621; rs6738656; rs7596703; rs799329

# Metabolic_Enzyme_4_General_References:
8786100; 7895732

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
6142

# Metabolic_Enzyme_5_Name:
Fumarate hydratase, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
Fumarase

# Metabolic_Enzyme_5_Gene_Name:
FH

# Metabolic_Enzyme_5_Protein_Sequence:
>Fumarate hydratase, mitochondrial precursor
MYRALRLLARSRPLVRAPAAALASAPGLGGAAVPSFWPPNAARMASQNSFRIEYDTFGEL
KVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAI
MKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDH
VNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAV
PLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAAL
TGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPE
NEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSA
RLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGS
TLKETAIELGYLTAEQFDEWVKPKDMLGPK

# Metabolic_Enzyme_5_Number_of_Residues:
510

# Metabolic_Enzyme_5_Molecular_Weight:
54638

# Metabolic_Enzyme_5_Theoretical_pI:
9.17

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-oxygen lyase activity
Function:  hydro-lyase activity
Function:  fumarate hydratase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  fumarate metabolism
 ||
>>>
Component:  protein complex
Component:  tricarboxylic acid cycle enzyme complex

# Metabolic_Enzyme_5_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_5_Specific_Function:
Also acts as a tumor suppressor

# Metabolic_Enzyme_5_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_5_Reaction:
(S)-malate = fumarate + H2O

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00206:Lyase_1

# Metabolic_Enzyme_5_Signals:
1-23

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 4.2.1.2

# Metabolic_Enzyme_5_GenBank_ID_Protein:
1545996

# Metabolic_Enzyme_5_SwissProt_ID:
FUMH_HUMAN (P07954)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
FH

# Metabolic_Enzyme_5_Geneatlas_id:
FH

# Metabolic_Enzyme_5_hgnc_id:
HGNC:3700

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion. Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1533 bp
ATGTACCGAGCACTTCGGCTCCTCGCGCGCTCGCGTCCCCTCGTGCGGGCTCCAGCCGCA
GCCTTAGCTTCGGCTCCCGGCTTGGGTGGCGCGGCCGTGCCCTCGTTTTGGCCTCCGAAC
GCGGCTCGAATGGCAAGCCAAAATTCCTTCCGGATAGAATATGATACCTTTGGTGAACTA
AAGGTGCCAAATGATAAGTATTATGGCGCCCAGACCGTGAGATCTACGATGAACTTTAAG
ATTGGAGGTGTGACAGAACGCATGCCAACCCCAGTTATTAAAGCTTTTGGCATCTTGAAG
CGAGCGGCCGCTGAAGTAAACCAGGATTATGGTCTTGATCCAAAGATTGCTAATGCAATA
ATGAAGGCAGCAGATGAGGTAGCTGAAGGTAAATTAAATGATCATTTTCCTCTCGTGGTA
TGGCAGACTGGATCAGGAACTCAGACAAATATGAATGTAAATGAAGTCATTAGCAATAGA
GCAATTGAAATGTTAGGAGGTGAACTTGGCAGCAAGATACCTGTGCATCCCAACGATCAT
GTTAATAAAAGCCAGAGCTCAAATGATACTTTTCCCACAGCAATGCACATTGCTGCTGCA
ATAGAAGTTCATGAAGTACTGTTACCAGGACTACAGAAGTTACATGATGCTCTTGATGCA
AAATCCAAAGAGTTTGCACAGATCATCAAGATTGGACGTACTCATACTCAGGATGCTGTT
CCACTTACTCTTGGGCAGGAATTTAGTGGTTATGTTCAACAAGTAAAATATGCAATGACA
AGAATAAAAGCTGCCATGCCAAGAATCTATGAGCTCGCAGCTGGAGGCACTGCTGTTGGT
ACAGGTTTAAATACTAGAATTGGCTTTGCAGAAAAGGTTGCTGCAAAAGTGGCTGCACTT
ACAGGCTTGCCTTTTGTCACTGCTCCGAATAAATTTGAAGCTCTGGCTGCTCATGACGCT
CTGGTTGAGCTCAGTGGAGCCATGAACACTACTGCCTGCAGTCTGATGAAGATAGCAAAT
GATATTCGATTTTTGGGTTCTGGTCCTCGGTCAGGTCTGGGAGAATTGATCTTGCCTGAA
AATGAACCAGGAAGCAGTATCATGCCAGGCAAGGTGAACCCTACTCAGTGTGAAGCAATG
ACCATGGTTGCAGCCCAAGTCATGGGGAACCATGTTGCTGTCACTGTCGGAGGCAGCAAT
GGACATTTTGAGTTGAATGTTTTCAAGCCAATGATGATTAAAAATGTGTTACACTCAGCC
AGGCTGCTGGGGGATGCTTCAGTTTCCTTTACAGAAAACTGCGTGGTGGGAATCCAGGCC
AATACAGAAAGGATCAACAAGCTGATGAATGAGTCTCTAATGTTGGTGACAGCTCTCAAT
CCTCATATAGGGTATGACAAGGCAGCAAAGATTGCTAAGACAGCACACAAAAATGGATCA
ACCTTAAAGGAAACTGCTATCGAACTTGGCTATCTCACAGCAGAGCAGTTTGACGAATGG
GTAAAACCTAAGGACATGCTGGGTCCAAAGTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U59309

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_5_Locus:
1q42.1

# Metabolic_Enzyme_5_SNPs:
rs1335898; rs4659607; rs2994990; rs2992644; rs11802956; rs2185626; rs3014577; rs11810820; rs10802968; rs4660099; rs12563264; rs6673988; rs4659606; rs11810810; rs10926500; rs10926499; rs12065955; rs12062672; rs1572380; rs2275162; rs4659608; rs11809211; rs4660098; rs12072899; rs12059383; rs12085636; rs2225788; rs2153694; rs947306; rs7530270; rs6678986; rs2153695; rs12071124; rs7414794; rs6679186; rs6681649; rs11545656; rs11545658; rs11545659; rs11545654; rs11545655; rs10926501; rs1049719; rs12087951; rs36061522; rs35911339; rs35806536; rs34169563; rs11811744; rs3014576; rs34340049; rs34519169; rs2341940; rs6689999; rs36216713; rs5782200; rs34461266; rs28593473; rs12059375; rs35459191; rs5782199; rs12058914; rs35724406; rs34171219; rs5782201; rs12759839; rs12057640; rs6143706; rs2992645; rs11463263; rs2341941; rs12047049; rs12075683; rs10548903; rs35416457; rs34827919; rs10560801; rs12401442; rs10926503; rs16841808; rs12754502; rs34007305; rs5782198; rs34516025; rs10754730; rs11810451; rs1414493; rs2994986; rs2994989; rs4431830; rs4601574; rs4660101; rs6678766; rs6693420; rs7514407; rs7536335; rs9729137

# Metabolic_Enzyme_5_General_References:
3828494; 9635293; 11865300

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
6143

# Metabolic_Enzyme_6_Name:
NAD-dependent malic enzyme, mitochondrial precursor

# Metabolic_Enzyme_6_Synonyms:
NAD-ME; Malic enzyme 2

# Metabolic_Enzyme_6_Gene_Name:
ME2

# Metabolic_Enzyme_6_Protein_Sequence:
>NADdependent malic enzyme, mitochondrial precursor
MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIET
QDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLAC
SQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIP
VGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMK
AITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISK
PISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDS
YQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALS
NPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVIL
CNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMA
FRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITE

# Metabolic_Enzyme_6_Number_of_Residues:
584

# Metabolic_Enzyme_6_Molecular_Weight:
65444

# Metabolic_Enzyme_6_Theoretical_pI:
7.67

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  malate dehydrogenase activity
Function:  malic enzyme activity
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  malate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_6_Specific_Function:
(S)-malate + NAD(+) = pyruvate + CO(2) + NADH

# Metabolic_Enzyme_6_Pathway:
map00620  Pyruvate metabolism

# Metabolic_Enzyme_6_Reaction:
(S)-malate + NAD+ = pyruvate + CO2 + NADH

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00390:malic;
PF03949:Malic_M

# Metabolic_Enzyme_6_Signals:
1-15

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.1.1.38

# Metabolic_Enzyme_6_GenBank_ID_Protein:
187300

# Metabolic_Enzyme_6_SwissProt_ID:
MAOM_HUMAN (P23368)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ME2

# Metabolic_Enzyme_6_Geneatlas_id:
ME2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:6984

# Metabolic_Enzyme_6_PDB_ID:
1QR6

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_6_Gene_Sequence:
>1755 bp
ATGTTGTCCCGGTTAAGAGTAGTTTCCACCACTTGTACTTTGGCATGTCGACATTTGCAC
ATAAAAGAAAAAGGCAAGCCACTTATGCTGAACCCAAGAACAAACAAGGGAATGGCATTT
ACTTTACAAGAACGACAAATGCTTGGTCTTCAAGGACTTCTACCTCCCAAAATAGAGACA
CAAGATATTCAAGCCTTACGATTTCATAGAAACTTGAAGAAAATGACTAGCCCTTTGGAA
AAATATATCTACATAATGGGAATACAAGAAAGAAATGAGAAATTGTTTTATAGAATACTG
CAAGATGACATTGAGAGTTTAATGCCAATTGTATATACACCGACGGTTGGTCTTGCCTGC
TCCCAGTATGGACACATCTTTAGAAGACCTAAGGGATTATTTATTTCGATCTCAGACAGA
GGTCATGTTAGATCAATTGTGGATAACTGGCCAGAAAATCATGTTAAGGCTGTTGTAGTG
ACTGATGGAGAGAGAATTCTGGGTCTTGGAGATCTGGGTGTCTATGGAATGGGAATTCCA
GTAGGAAAACTTTGTTTGTATACAGCTTGTGCAGGAATACGGCCTGATAGATGCCTGCCA
GTGTGTATTGATGTGGGAACTGATAATATCGCACTCTTAAAAGACCCATTTTACATGGGC
TTGTACCAGAAACGAGATCGCACACAACAGTATGATGACCTGATTGATGAGTTTATGAAA
GCTATTACTGACAGATATGGCCGGAACACACTCATTCAGTTCGAAGACTTTGGAAATCAT
AATGCATTCAGGTTCTTGAGAAAGTACCGAGAAAAATATTGTACTTTCAATGATGATATT
CAAGGGACAGCTGCAGTAGCTCTAGCAGGTCTTCTTGCAGCACAAAAAGTTATTAGTAAA
CCAATCTCCGAACACAAAATCTTATTCCTTGGAGCAGGAGAGGCTGCTCTTGGAATTGCA
AATCTTATAGTTATGTCTATGGTAGAAAATGGCCTGTCAGAACAAGAGGCACAAAAGAAA
ATCTGGATGTTTGACAAGTATGGTTTATTAGTTAAGGGACGGAAAGCAAAAATAGATAGT
TATCAGGAACCATTTACTCACTCAGCCCCAGAGAGCATACCTGATACTTTTGAAGATGCA
GTGAATATACTGAAGCCTTCAACTATTATTGGAGTTGCAGGTGCTGGCCGTCTTTTCACT
CCTGATGTAATCAGAGCCATGGCCTCTATCAATGAAAGGCCTGTAATATTTGCATTAAGT
AATCCTACAGCACAGGCAGAGTGCACGGCTGAAGAAGCATATACACTTACAGAGGGCAGG
TGTTTGTTTGCCAGTGGCAGTCCATTTGGGCCAGTGAAACTTACAGATGGGCGAGTCTTT
ACACCAGGTCAAGGAAACAATGTTTATATTTTTCCAGGTGTGGCTTTAGCTGTTATTCTC
TGTAACACCCGGCATATTAGTGACAGTGTTTTCCTAGAAGCTGCAAAGGCCCTGACAAGC
CAATTGACAGATGAAGAGCTAGCCCAAGGGAGACTTTACCCACCGCTTGCTAATATTCAG
GAAGTTTCTATTAACATTGCTATTAAAGTTACAGAATACCTATATGCTAATAAAATGGCT
TTCCGATACCCAGAACCTGAAGACAAGGCCAAATATGTTAAAGAAAGAACATGGCGGAGT
GAATATGATTCCCTGCTGCCAGATGTGTATGAATGGCCAGAATCTGCATCAAGCCCTCCT
GTGATAACAGAATAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M55905

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:18

# Metabolic_Enzyme_6_Locus:
6p25-p24|18q21

# Metabolic_Enzyme_6_SNPs:
rs649224; rs16952692; rs673486; rs1789221; rs12277; rs686709; rs625566; rs2665561; rs591852; rs1790496; rs1510394; rs1790498; rs686315; rs608781; rs1510395; rs16952715; rs9947907; rs12957551; rs2850545; rs9947610; rs1510396; rs669259; rs623306; rs6508042; rs685533; rs674210; rs678046; rs654136; rs645088; rs2427777; rs1789226; rs592209; rs686210; rs8085716; rs632624; rs631489; rs584357; rs9958074; rs608986; rs677978; rs675649; rs1033060; rs642698; rs1789223; rs582604; rs1510392; rs8098028; rs665361; rs665681; rs605902; rs2457642; rs660363; rs1789222; rs642633; rs608592; rs584333; rs8082890; rs643078; rs2510525; rs633145; rs8082752; rs9304406; rs11876870; rs16952711; rs16952689; rs2665570; rs4940027; rs2850544; rs16952681; rs613245; rs9947382; rs616771; rs4940028; rs4527115; rs627334; rs7233901; rs2271306; rs687084; rs9949309; rs614152; rs2427782; rs583574; rs11874006; rs9953741; rs7227245; rs1397266; rs11876847; rs687550; rs2850542; rs2255610; rs674044; rs34223640; rs35613895; rs35171058; rs1790497; rs12454614; rs657111; rs10611883; rs2040292; rs35758811; rs35918847; rs17841725; rs10609964; rs34655982; rs628918; rs1049543; rs9959158; rs35624319; rs655269; rs8094580; rs33946334; rs28603096; rs8091808; rs35304074; rs10599201; rs35330777; rs34983440; rs627503; rs1049533; rs12957847; rs2665560; rs1704769; rs34895453; rs7238525; rs1130629; rs34911971; rs1789229; rs3210033; rs35669230; rs34435967; rs36212168; rs35700268; rs2665563; rs34744606; rs12457827; rs35338017; rs34091188; rs8099477; rs10653824; rs36095112; rs35213488; rs687545; rs34466188; rs11463139; rs36103980; rs12963517; rs10469009; rs34525581; rs11447571; rs4940030; rs3838888; rs9953876; rs3838889; rs17743564; rs36076772; rs35437933; rs35479412; rs34143282; rs34993879; rs34098756; rs1790492; rs2457641; rs678903; rs12959353; rs9675349; rs582571; rs34642516; rs35234326; rs4939647; rs2511035; rs34824733; rs8087175; rs2226863; rs35229158; rs4041743; rs33979053; rs34704518; rs1789227; rs660408; rs1790501; rs11330978; rs35610140; rs33935499; rs36215672; rs12959356; rs5824856; rs34638462; rs28603360; rs2457639; rs11388576; rs35679758; rs7227116; rs10698671; rs2665562; rs34374625; rs600170; rs35028652; rs2511036; rs1510393; rs17805589; rs695024; rs12961166; rs2427778; rs1789224; rs34855380; rs35156920; rs34295135; rs35061724; rs34701399; rs35790070; rs8084506; rs12961845; rs8088183; rs2511038; rs34134918; rs10469008; rs1790493; rs34600128; rs35741063; rs34336639; rs604138; rs11320316; rs34103452; rs17743501; rs34526861; rs2510526; rs34237284; rs10164231; rs12958982; rs12953514; rs3051031; rs2511037; rs35785739; rs34743541; rs12961211; rs4940029; rs8088812; rs34912320; rs4041744; rs584788; rs5824855; rs1625481; rs1790491; rs35828774; rs3017639; rs10636386; rs28636391; rs34304618; rs3897954; rs35869317; rs9675859; rs28543025; rs1018245; rs33994859; rs5824854; rs674488; rs36071145; rs11873705; rs12964888; rs17743658; rs1787114; rs1810130; rs2089743; rs2457640; rs2665558; rs2665572; rs2851742; rs585344; rs597160; rs630689; rs647527; rs659666; rs661327; rs676678; rs685373

# Metabolic_Enzyme_6_General_References:
1993674; 11401430; 12665801; 12121650; 12962632

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
6687

# Metabolic_Enzyme_7_Name:
Proto-oncogene tyrosine-protein kinase FGR

# Metabolic_Enzyme_7_Synonyms:
P55-FGR; C- FGR

# Metabolic_Enzyme_7_Gene_Name:
FGR

# Metabolic_Enzyme_7_Protein_Sequence:
>Protooncogene tyrosineprotein kinase 
FGRMGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFS
SQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA
RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK
GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL
IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT
MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP
QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG
SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM
PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT

# Metabolic_Enzyme_7_Number_of_Residues:
529

# Metabolic_Enzyme_7_Molecular_Weight:
59479

# Metabolic_Enzyme_7_Theoretical_pI:
5.29

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  protein-tyrosine kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
Not Available

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF07714:Pkinase_Tyr;
PF00017:SH2;
PF00018:SH3_1

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.7.10.2

# Metabolic_Enzyme_7_GenBank_ID_Protein:
182574

# Metabolic_Enzyme_7_SwissProt_ID:
FGR_HUMAN (P09769)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
FGR

# Metabolic_Enzyme_7_Geneatlas_id:
FGR

# Metabolic_Enzyme_7_hgnc_id:
HGNC:3697

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>1590 bp
ATGGGCTGTGTGTTCTGCAAGAAATTGGAGCCGGTGGCCACGGCCAAGGAGGATGCTGGC
CTGGAAGGGGACTTCAGAAGCTACGGGGCAGCAGACCACTATGGGCCTGACCCCACTAAG
GCCCGGCCTGCATCCTCATTTGCCCACATCCCCAACTACAGCAACTTCTCCTCTCAGGCC
ATCAACCCTGGCTTCCTTGATAGTGGCACCATCAGGGGTGTGTCAGGGATTGGGGTGACC
CTGTTCATTGCCCTGTATGACTATGAGGCTCGAACTGAGGATGACCTCACCTTCACCAAG
GGCGAGAAGTTCCACATCCTGAACAATACTGAAGGTGACTGGTGGGAGGCTCGGTCTCTC
AGCTCCGGAAAAACTGGCTGCATTCCCAGCAACTACGTGGCCCCTGTTGACTCAATCCAA
GCTGAAGAGTGGTACTTTGGAAAGATTGGGAGAAAGGATGCAGAGAGGCAGCTGCTTTCA
CCAGGCAACCCCCAGGGGGCCTTTCTCATTCGGGAAAGCGAGACCACCAAAGGTGCCTAC
TCCCTGTCCATCCGGGACTGGGATCAGACCAGAGGCGATCATGTGAAGCATTACAAGATC
CGCAAACTGGACATGGGCGGCTACTACATCACCACACGGGTTCAGTTCAACTCGGTGCAG
GAGCTGGTGCAGCACTACATGGAGGTGAATGACGGGCTGTGCAACCTGCTCATCGCGCCC
TGCACCATCATGAAGCCGCAGACGCTGGGCCTGGCCAAGGACGCCTGGGAGATCAGCCGC
AGCTCCATCACGCTGGAGCGCCGGCTGGGCACCGGCTGCTTCGGGGATGTGTGGCTGGGC
ACGTGGAACGGCAGCACTAAGGTGGCGGTGAAGACGCTGAAGCCGGGCACCATGTCCCCG
AAGGCCTTCCTGGAGGAGGCGCAGGTCATGAAGCTGCTGCGGCACGACAAGCTGGTGCAG
CTGTACGCCGTGGTGTCGGAGGAGCCCATCTACATCGTGACCGAGTTCATGTGTCACGGC
AGCTTGCTGGATTTTCTCAAGAACCCAGAGGGCCAGGATTTGAGGCTGCCCCAATTGGTG
GACATGGCAGCCCAGGTAGCTGAGGGCATGGCCTACATGGAACGCATGAACTACATTCAC
CGCGACCTGAGGGCAGCCAACATCCTGGTTGGGGAGCGGCTGGCGTGCAAGATCGCAGAC
TTTGGCTTGGCGCGTCTCATCAAGGACGATGAGTACAACCCCTGCCAAGGTTCCAAGTTC
CCCATCAAGTGGACAGCCCCAGAAGCTGCCCTCTTTGGCAGATTCACCATCAAGTCAGAC
GTGTGGTCCTTTGGGATCCTGCTCACTGAGCTCATCACCAAGGGCCGAATCCCCTACCCA
GGCATGAATAAACGGGAAGTGTTGGAACAGGTGGAGCAGGGCTACCACATGCCGTGCCCT
CCAGGCTGCCCAGCATCCCTGTACGAGGCCATGGAACAGACCTGGCGTCTGGACCCGGAG
GAGAGGCCTACCTTCGAGTACCTGCAGTCCTTCCTGGAGGACTACTTCACCTCCGCTGAA
CCACAGTACCAGCCCGGGGATCAGACATAG

# Metabolic_Enzyme_7_GenBank_ID_Gene:
M19722

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_7_Locus:
1p36.2-p36.1

# Metabolic_Enzyme_7_SNPs:
rs2231877; rs2231870; rs761069; rs11800755; rs2231874; rs17162676; rs11800191; rs2231871; rs2231876; rs2231873; rs17362027; rs11802103; rs1292089; rs2231872; rs2231868; rs17162673; rs2231863; rs6598891; rs878648; rs4508035; rs34597831; rs35334091; rs2231878; rs34718693; rs2231869; rs2231867; rs2231883; rs1890463; rs2231875; rs5773194; rs35558221; rs2231881; rs12758939; rs12049219; rs12075682; rs2231879; rs35024740; rs2231882; rs33991727; rs10701577; rs12096621; rs2231880; rs2231864; rs34000614; rs35879602; rs2231865; rs10695181; rs34737291; rs2231866; rs28546507; rs11576582; rs11802278; rs11802297; rs11809483; rs12039836; rs12726763; rs1292073; rs17162665; rs1890462; rs4908343; rs545502; rs6658795; rs6677501

# Metabolic_Enzyme_7_General_References:
3275868; 2852026; 3330776; 1690869; 3023853

# Metabolic_Enzyme_7_References:
16520665; 17136543

# Metabolic_Enzyme_8_ID:
5409

# Metabolic_Enzyme_8_Name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor

# Metabolic_Enzyme_8_Synonyms:
NADH-ubiquinone oxidoreductase 39 kDa subunit; Complex I-39kD; CI-39kD

# Metabolic_Enzyme_8_Gene_Name:
NDUFA9

# Metabolic_Enzyme_8_Protein_Sequence:
>NADH dehydrogenase ubiquinone 1 alpha subcomplex subunit 9, mitochondrial precursor
MAAAAQSRVVRVLSMSRSAITAIATSVCHGPPCRQLHHALMPHGKGGRSSVSGIVATVFG
ATGFLGRYVVNHLGRMGSQVIIPYRCDKYDIMHLRPMGDLGQLLFLEWDARDKDSIRRVV
QHSNVVINLIGRDWETKNFDFEDVFVKIPQAIAQLSKEAGVEKFIHVSHLNANIKSSSRY
LRNKAVGEKVVRDAFPEAIIVKPSDIFGREDRFLNSFASMHRFGPIPLGSLGWKTVKQPV
YVVDVSKGIVNAVKDPDANGKSFAFVGPSRYLLFHLVKYIFAVAHRLFLPFPLPLFAYRW
VARVFEISPFEPWITRDKVERMHITDMKLPHLPGLEDLGIQATPLELKAIEVLRRHRTYR
WLSAEIEDVKPAKTVNI

# Metabolic_Enzyme_8_Number_of_Residues:
377

# Metabolic_Enzyme_8_Molecular_Weight:
42510

# Metabolic_Enzyme_8_Theoretical_pI:
10.37

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide-sugar metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_8_Specific_Function:
Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

# Metabolic_Enzyme_8_Pathway:
map00190  Oxidative phosphorylation

# Metabolic_Enzyme_8_Reaction:
NADH + H+ + acceptor = NAD+ + reduced acceptor

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF01370:Epimerase

# Metabolic_Enzyme_8_Signals:
1-24

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.6.5.3;EC 1.6.99.3

# Metabolic_Enzyme_8_GenBank_ID_Protein:
5326823

# Metabolic_Enzyme_8_SwissProt_ID:
NDUA9_HUMAN (Q16795)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
NDUFA9

# Metabolic_Enzyme_8_Geneatlas_id:
NDUFA9

# Metabolic_Enzyme_8_hgnc_id:
HGNC:7693

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_8_Gene_Sequence:
>1134 bp
ATGGCGGCTGCCGCACAATCCCGGGTTGTCCGGGTCCTGTCAATGTCACGTTCTGCCATT
ACTGCAATAGCCACATCTGTGTGTCACGGCCCACCCTGTCGCCAGCTTCATCATGCCCTC
ATGCCTCATGGGAAAGGTGGACGTTCCTCAGTCAGTGGGATTGTGGCCACTGTGTTTGGA
GCAACAGGATTCCTGGGGCGATATGTTGTCAACCACCTTGGACGCATGGGGTCACAGGTA
ATCATACCCTATCGGTGTGATAAATATGACATCATGCACCTTCGTCCCATGGGTGACCTG
GGCCAGCTTCTGTTTCTGGAATGGGACGCGAGAGATAAAGATTCTATCCGACGAGTAGTA
CAACACAGCAATGTGGTCATCAATCTTATTGGACGAGACTGGGAAACCAAAAACTTTGAT
TTTGAGGATGTTTTTGTGAAGATTCCCCAAGCAATTGCTCAACTGTCCAAGGAAGCTGGA
GTTGAAAAATTCATTCATGTTTCACATCTGAATGCGAATATTAAAAGCTCTTCTAGATAT
TTGAGAAATAAGGCTGTTGGAGAGAAAGTAGTGAGAGATGCATTTCCGGAAGCCATTATC
GTAAAGCCGTCGGACATCTTTGGAAGAGAGGATAGATTCCTTAATTCTTTTGCAAGTATG
CATCGGTTTGGTCCTATACCCCTTGGTTCCTTGGGCTGGAAGACAGTTAAACAACCAGTA
TATGTCGTAGATGTATCCAAAGGAATTGTTAATGCAGTTAAGGATCCTGATGCCAATGGG
AAATCCTTTGCTTTCGTTGGTCCCAGTCGGTACCTCCTTTTCCACCTGGTGAAGTACATC
TTTGCTGTGGCTCACAGATTGTTCCTCCCATTCCCCTTGCCGCTTTTTGCCTATCGATGG
GTAGCAAGAGTCTTTGAAATAAGCCCATTTGAGCCCTGGATAACAAGGGATAAAGTGGAG
CGGATGCACATCACAGACATGAAATTGCCTCACCTGCCTGGCTTAGAAGACCTTGGTATT
CAGGCAACACCACTGGAACTCAAGGCCATTGAGGTGCTGCGGCGTCATCGCACTTACCGC
TGGCTGTCTGCTGAAATTGAGGATGTGAAGCCGGCCAAGACCGTCAACATTTAG

# Metabolic_Enzyme_8_GenBank_ID_Gene:
AF050641

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_8_Locus:
12p13.3

# Metabolic_Enzyme_8_SNPs:
rs3210086; rs3210089; rs2058204; rs2267552; rs2159352; rs2240762; rs2240760; rs2267550; rs2302247; rs4147675; rs4147674; rs1009634; rs2302246; rs4147671; rs7972657; rs7972920; rs4147695; rs10849118; rs6489558; rs2267549; rs4147693; rs11614030; rs4147683; rs2267548; rs7978162; rs11610038; rs2191156; rs7972501; rs17701871; rs1009633; rs1990311; rs4147672; rs10849115; rs1029767; rs11832426; rs11063282; rs7302268; rs4766273; rs11834553; rs11615364; rs2270134; rs12308883; rs2159351; rs10774256; rs16931634; rs4766269; rs16931616; rs4147684; rs4147685; rs7312558; rs4147673; rs2302244; rs11614014; rs2074984; rs12309713; rs10774258; rs7958182; rs16931620; rs4147686; rs4147677; rs7313982; rs2267551; rs10774260; rs12578481; rs11063285; rs2359253; rs7977127; rs4147691; rs11831461; rs10744657; rs2240761; rs10774257; rs12811453; rs6489557; rs3832857; rs12230096; rs11063283; rs7958603; rs4147690; rs2098090; rs10774259; rs4766272; rs10735037; rs4147694; rs2359252; rs7957498; rs4147689; rs4147682; rs11063279; rs7306593; rs979878; rs4147668; rs714621; rs4147666; rs2072354; rs4147667; rs979877; rs4766274; rs34076756; rs3210080; rs3210081; rs3210082; rs35263902; rs35155742; rs3210084; rs3210083; rs3210078; rs3210079; rs3210087; rs3210090; rs1130652; rs3210092; rs3210085; rs3210091; rs3210088; rs34342431; rs11524031; rs35792516; rs34393298; rs11831530; rs4147687; rs3217056; rs11399779; rs11063295; rs4147676; rs10657164; rs11063288; rs12231026; rs35167443; rs11519562; rs35165897; rs34954412; rs10082907; rs4147704; rs34214125; rs4766270; rs12818450; rs7295177; rs35596259; rs12318966; rs34909947; rs12302355; rs10128935; rs35350007; rs12226986; rs35355744; rs11063280; rs10732600; rs11063290; rs12298315; rs34819451; rs34401055; rs12228505; rs4147688; rs35118459; rs12818965; rs35195906; rs4147705; rs4147679; rs4147706; rs35245583; rs11063293; rs36123509; rs34173659; rs4147699; rs2302245; rs4147700; rs4147680; rs34373209; rs12817553; rs4147681; rs34067320; rs4147703; rs11063287; rs10631547; rs4147702; rs12227597; rs972770; rs7301282; rs4766271; rs4147701; rs4147678; rs28517481; rs34665019; rs12296168; rs12312427; rs11335422; rs12370353; rs11269329; rs4766268; rs10083152; rs34947765; rs7309135; rs7310700; rs4147697; rs1049576; rs4147698; rs4147669; rs15550; rs1049575; rs35665304; rs35984186; rs10219646; rs1024655; rs1024656; rs10774254; rs10774255; rs10849112; rs10849120; rs11615397; rs12297134; rs12301141; rs12301359; rs12302577; rs12310365; rs12580262; rs16931645; rs1990310; rs34047542; rs4147696; rs4766265; rs4766266; rs4766267; rs6489559; rs6489560; rs7132398; rs7136583; rs7298334; rs7310971; rs7312402; rs7314381; rs7971891

# Metabolic_Enzyme_8_General_References:
8012384; 8486360

# Metabolic_Enzyme_8_References:
11677254; 11693531; 12840017; 15047621

# Macromolecular_Interacting_Partner_1_ID:
7549

# Macromolecular_Interacting_Partner_1_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
INS

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_1_Signals:
1-24

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
INS

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11p15.5

# Macromolecular_Interacting_Partner_1_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_1_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_1_References:
16916949

# Macromolecular_Interacting_Partner_2_ID:
7113

# Macromolecular_Interacting_Partner_2_Name:
Cytochrome c

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
CYCS

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Cytochrome c
MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSYTAANKNKGIIW
GEDTLMEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNE

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
105

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
11749

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
10.16

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  binding
Function:  tetrapyrrole binding
Function:  heme binding
Function:  transporter activity
Function:  electron transporter activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Energy production and conversion 

# Macromolecular_Interacting_Partner_2_Specific_Function:
Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00034:Cytochrom_C

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
181242

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
CYC_HUMAN (P99999)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
CYCS

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
CYCS

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:19986

# Macromolecular_Interacting_Partner_2_PDB_ID:
1J3S

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>318 bp
ATGGGTGATGTTGAGAAAGGCAAGAAGATTTTTATTATGAAGTGTTCCCAGTGCCACACC
GTTGAAAAGGGAGGCAAGCACAAGACTGGGCCAAATCTCCATGGTCTCTTTGGGCGGAAG
ACAGGTCAGGCCCCTGGATACTCTTACACAGCCGCCAATAAGAACAAAGGCATCATCTGG
GGAGAGGATACACTGATGGAGTATTTGGAGAATCCCAAGAAGTACATCCCTGGAACAAAA
ATGATCTTTGTCGGCATTAAGAAGAAGGAAGAAAGGGCAGACTTAATAGCTTATCTCAAA
AAAGCTACTAATGAGTAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M22877

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_2_Locus:
7p15.2

# Macromolecular_Interacting_Partner_2_SNPs:
rs11769363; rs7810784; rs1861525; rs12700584; rs10215217; rs4719799; rs12700583; rs12700582; rs3846998; rs2107123; rs11548785; rs11548815; rs11548798; rs11548802; rs11548799; rs11548820; rs11548772; rs11548783; rs11548796; rs11548816; rs11548795; rs3211452; rs11548791; rs11548818; rs11548805; rs3211451; rs11548807; rs11548778; rs17851278; rs11548812; rs11548776; rs11548797; rs11548779; rs11548806; rs11548774; rs11548777; rs11427893; rs1137513; rs3173604; rs11548775; rs1060389; rs1137505; rs1137510; rs11548804; rs1801082; rs1060388; rs1137506; rs11548773; rs41275976; rs1137512; rs1137508; rs13310377; rs13310456; rs34522469; rs35325343; rs1137507; rs11548787; rs1137511; rs10230102; rs11548792; rs28376346; rs1137509; rs36061386; rs6967260; rs3040291; rs16873757; rs5882962; rs34102874; rs34500218; rs10238032; rs17150957; rs10278815; rs10279024; rs10951046; rs11489282; rs12700580; rs2107121; rs2107122; rs2391087; rs2717885; rs2717886

# Macromolecular_Interacting_Partner_2_General_References:
2849112; 12853948; 9515723

# Macromolecular_Interacting_Partner_2_References:
11124957; 11167513; 12948388

# Macromolecular_Interacting_Partner_3_ID:
6172

# Macromolecular_Interacting_Partner_3_Name:
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
Phosphoenolpyruvate carboxylase; PEPCK-M

# Macromolecular_Interacting_Partner_3_Gene_Name:
PCK2

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Phosphoenolpyruvate carboxykinase GTP, mitochondrial precursor
MAALYRPGLRLNWHGLSPLGWPSCRSIQTLRVLSGDLGQLPTGIRDFVEHSARLCQPEGI
HICDGTEAENTATLTLLEQQGLIRKLPKYNNCWLARTDPKDVARVESKTVIVTPSQRDTV
PLPPGGARGQLGNWMSPADFQRAVDERFPGCMQGRTMYVLPFSMGPVGSPLSRIGVQLTD
SAYVVASMRIMTRLGTPVLQALGDGDFVKCLHSVGQPLTGQGEPVSQWPCNPEKTLIGHV
PDQREIISFGSGYGGNSLLGKKCFALRIASRLARDEGWLAEHMLILGITSPAGKKALCAA
AFPSACGKTNLAMMRPALPGWKVECVGDDIAWMRFDSEGRLRAINPENGFFGVAPGTSAT
TNPNAMATIQSNTIFTNVAETSDGGVYWEGIDQPLPPGVTVTSWLGKPWKPGDKEPCAHP
NSRFCAPARQCPIMDPAWEAPEGVPIDAIIFGGRRPKGVPLVYEAFNWRHGVFVGRAMRS
ESTAAAEHKGKIIMHDPFAMRPFFGYNFGHYLEHWLSMEGRKGAQLPRIFHVNWFRRDEA
GHFLWPGFGENARVLDWICRRLEGEDSARETPIGLVPKEGALDLSGLRAIDTTQLFSLPK
DFWEQEVRDIRSYLTEQVNQDLPKEVLAELEALERRVHKM

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
640

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
70638

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
7.65

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  guanyl nucleotide binding
Function:  GTP binding
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
Function:  phosphoenolpyruvate carboxykinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  gluconeogenesis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Energy production and conversion 

# Macromolecular_Interacting_Partner_3_Specific_Function:
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO(2)

# Macromolecular_Interacting_Partner_3_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00620  Pyruvate metabolism

# Macromolecular_Interacting_Partner_3_Reaction:
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00821:PEPCK

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
EC 4.1.1.32

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
1403050

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
PPCKM_HUMAN (Q16822)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
PCK2

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
PCK2

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:8725

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Mitochondrion

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1923 bp
ATGGCCGCATTGTACCGCCCTGGCCTGCGGCTTAACTGGCATGGGCTGAGCCCCTTGGGC
TGGCCATCATGCCGTAGCATCCAGACCCTGCGAGTGCTTAGTGGAGATCTGGGCCAGCTT
CCCACTGGCATTCGAGATTTTGTAGAGCACAGTGCCCGCCTGTGCCAACCAGAGGGCATC
CACATCTGTGATGGAACTGAGGCTGAGAATACTGCCACACTGACCCTGCTGGAGCAGCAG
GGCCTCATCCGAAAGCTCCCCAAGTACAATAACTGCTGGCTGGCCCGCACAGACCCCAAG
GATGTGGCACGAGTAGAGAGCAAGACGGTGATTGTAACTCCTTCTCAGCGGGACACGGTA
CCACTCCCGCCTGGTGGGGCCTGTGGGCAGCTGGGCAACTGGATGTCCCCAGCTGATTTC
CAGCGAGCTGTGGATGAGAGGTTTCCAGGCTGCATGCAGGGCCGCACCATGTATGTGCTT
CCATTCAGCATGGGTCCTGTGGGCTCCCCGCTGTCCCGCATCGGGGTGCAGCTCACTGAC
TCAGCCTATGTGGTGGCAAGCATGCGTATTATGACCCGACTGGGGACACCTGTGCTTCAG
GCCCTGGGAGATGGTGACTTTGTCAAGTGTCTGCACTCCGTGGGCCAGCCCCTGACAGGA
CAAGGGGAGCCAGTGAGCCAGTGGCCGTGCAACCCAGAGAAAACCCTGATTGGCCACGTG
CCCGACCAGCGGGAGATCATCTCCTTCGGCAGCGGCTATGGTGGCAACTCCCTGCTGGGC
AAGAAGTGCTTTGCCCTACGCATCGCCTCTCGGCTGGCCCGGGATGAGGGCTGGCTGGCA
GAGCACATGCTGATCCTGGGCATCACCAGCCCTGCAGGGAAGAAGGCGCTATGTGCAGCC
GCCTTCCCTAGTGCCTGTGGCAAGACCAACCTGGCTATGATGCGGCCTGCACTGCCAGGC
TGGAAAGTGGAGTGTGTGGGGGATGATATTGCTTGGATGAGGTTTGACAGTGAAGGTCGA
CTCCGGGCCATCAACCCTGAGAACGGCTTCTTTGGGGTTGCCCCTGGTACCTCTGCCACC
ACCAATCCCAACGCCATGGCTACAATCCAGAGTAACACTATTTTTACCAATGTGGCTGAG
ACCAGTGATGGTGGCGTGTACTGGGAGGGCATTGACCAGCCTCTTCCACCTGGTGTTACT
GTGACCTCCTGGCTGGGCAAACCCTGGAAACCTGGTGACAAGGAGCCCTGTGCACATCCC
AACTCTCGATTTTGTGCCCCGGCTCGCCAGTGCCCCATCATGGACCCAGCCTGGGAGGCC
CCAGAGGGTGTCCCCATTGACGCCATCATCTTTGGTGGCCGCAGACCCAAAGGGGTACCC
CTGGTATACGAGGCCTTCAACTGGCGTCATGGGGTGTTTGTGGGCAGAGCCATGCGCTCT
GAGTCCACTGCTGCAGCAGAACACAAAGGGAAGATCATCATGCACGACCCATTTGCCATG
CGGCCCTTTTTTGGCTACAACTTCGGGCACTACCTGGAACACTGGCTGAGCATGGAAGGG
CGCAAGGGGGCCCAGCTGCCCCGTATCTTCCATGTCAACTGGTTCCGGCGTGACGAGGCA
GGGCACTTCCTGTGGCCAGGCTTTGGGGAGAATGCTCGGGTGCTAGACTGGATCTGCCGG
CGGTTAGAGGGGGAGGACAGTGCCCGAGAGACACCCATTGGGCTGGTGCCAAAGGAAGGA
GCCTTGGATCTCAGCGGCCTCAGAGCTATAGACACCACTCAGCTGTTCTCCCTCCCCAAG
GACTTCTGGGAACAGGAGGTTCGTGACATTCGGAGCTACCTGACAGAGCAGGTCAACCAG
GATCTGCCCAAAGAGGTGTTGGCTGAGCTTGAGGCCCTGGAGAGACGTGTGCACAAAATG
TGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
X92720

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_3_Locus:
14q12

# Macromolecular_Interacting_Partner_3_SNPs:
Not Available

# Macromolecular_Interacting_Partner_3_General_References:
8645161; 9657976

# Macromolecular_Interacting_Partner_3_References:
11373308; 11741859; 12598577; 12773523

# Macromolecular_Interacting_Partner_4_ID:
7803

# Macromolecular_Interacting_Partner_4_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_4_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_4_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_4_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_4_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_4_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_4_References:
12676672; 12770702; 15013205

End of HMDB00156

Beginning of HMDB00157
# Accession_No:
HMDB00157

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-22 16:52:36

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Hypoxanthine

# Description:
A naturally occurring purine derivative and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway. Hypoxanthine is also a spontaneous deamination product of adenine.
Lesch-Nyhan disease is caused by deficiency of the purine salvage enzyme hypoxanthine-guanine phosphoribosyltransferase. (OMIN 308000)


# Synonyms:
1,7-Dihydro-6H-purin-6-one; 1,7-Dihydro-6H-purine-6-one; 1H,7H-Hypoxanthine; 3H-Purin-6-ol; 4-Hydroxy-1H-purine; 6(1H)-Purinone; 6-Hydroxy-1H-purine; 6-Hydroxypurine; 6-Oxopurine; 7H-Purin-6-ol; 9H-Purin-6(1H)-one; 9H-Purin-6-ol; Hypoxanthine enol; Purin-6(1H)-one; Purin-6(3H)-one; Purin-6-ol; Purine-6-ol; Sarcine; Sarkin; Sarkine

# Chemical_IUPAC_Name:
3,7-dihydropurin-6-one

# Chemical_Formula:
C5H4N4O

# Chemical_Structure:
tbl_chemical:::HMDB00157_ZOOM.png:::119283223646613302

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00157_THUMB.png:::119283223487995555

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
oxo(het)arene; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of Purine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
136.03851

# Molecular_Weight_Avg:
136.11147

# Smiles_String_isomeric:
OC1=NC=NC2=C1NC=N2

# Smiles_String_canonical:
OC1=NC=NC2=C1NC=N2

# KEGG_Compound_ID:
C00262

# BioCyc_ID:
HYPOXANTHINE

# PubChem_CID:
790

# PubChem_SID:
584306; 11088539; 831185; 11491167; 12814911; 819070; 11361915; 6356782; 823442; 834961; 618936; 819073; 10532804; 10409720; 6282154; 11493556; 825006; 5248991; 11375322; 831141; 11369435; 831143; 11377597; 11364311; 3133523; 829665; 834254; 589179; 831184; 11366873; 11485610; 954106; 834958; 11536560; 3560; 2813; 11487317; 823494; 833975; 11372482; 7990157; 7888201; 831142; 11489723; 8144165; 6380308; 10409796; 823441; 833880; 819071; 825005; 11538005; 11341732; 831180; 11495231; 149159

# OMIM_ID:
164050; 252150; 300323; 312840

# Metagene_ID:
XANTHINURIA TYPE I: 59; ASPHYXIA [DD]: 408; XANTHINURIA TYPE II: 483; MOLYBDENIUM CO-FACTOR DEFICIENCY. SULFITE OXIDASE DEFICIENCY: 116

# BiGG_ID:
34434

# Wikipedia_ID:
Hypoxanthine

# METLIN_ID:
83

# Ref_ID:
8723362; 11574951; 15536609; 6872216; 3140152; 1711835; 12829005; 2611770; 7957429; 9020983; 16324927; 15882454; 10534552; 6656991; 11398135; 1958086; 10494902

# ChEBI_ID:
17368

# CAS_Registry_Number:
68-94-0

# InChI:
InChI=1/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)

# Synthesis_Reference:
New synthesis of the purines adenine, hypoxanthine, xanthine, and isoguanine.     Shaw, Elliott.    Rockefeller Inst.,  New York,  NY,    Journal of Biological Chemistry  (1950),  185  439-47.

# Melting_Point:
150 oC

# Melting_Point_predicted:
117.9 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.7 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]; 5 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
13.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-1.11 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-0.54 [Predicted by ALOGPS]; -0.6 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Hypoxanthine.pdf:::1132562207850611645

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Hypoxanthine.mol:::1132723810578425875

# SDF_File_[Text]:
tbl_chemical:::HMDB00157.sdf:::119283223204755482

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00157.pdb:::119283223351654208

# PDB_ID:
1A9Q

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041028_P00_04_HW_1DP_presat.png:::115108342031679450

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041028_P00_04_HW_1DP_presat_1.zip:::114720327767656481

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041028_P00_04_HW_1DP_Assigned.png:::115679887688646866

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Hypoxanthine.gif:::1132732115062599064

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00157_peaks.txt:::115630958237912264

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Hypoxanthine_C.gif:::1132737702882774472

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00157_peaks.txt:::1156310772140395797

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00157L.png:::117555262159371929; Medium Energy:tbl_ms:::HMDB00157M.png:::117555267251821645; High Energy:tbl_ms:::HMDB00157H.png:::117555271097530699

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000094.png:::116890826615658470

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000094.txt:::116890826642126392

# Cellular_Location:
Cytoplasm; Extracellular; lysosome; peroxisome

# Tissue_Location:
Adipose Tissue; Epidermis; Erythrocyte; Fibroblasts; Intestine; Muscle; Placenta; Platelet; Skeletal Muscle; Spleen; Testes

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Cellular Cytoplasm; Urine

# Concentration_[Normal]:
Blood	1.0 +/- 0.9	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	5.6 (3.1-7.1)	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	0.38 (0.20-0.56)	umol/L	Adult:>18_yrs_old	Both	Normal	16324927
Cerebrospinal_Fluid(CSF)	5.94 (5.20-6.68)	umol/L	Adult:>18_yrs_old	Both	Normal	2611770
Cellular_Cytoplasm	2	umol/L	Adult:>18_yrs_old	Both	Normal	15882454


# Concentration_[Abnormal]:
Urine	6.8 +/- 4.8	umol/mmol_creatinine	N/A	Both	Lung Cancer	
Cerebrospinal_Fluid(CSF)	5.71 (3.99-7.43)	umol/L	Adult:>18_yrs_old	Both	Self-compensated hydrocephalics	2611770
Cerebrospinal_Fluid(CSF)	9.91 (8.01-11.8)	umol/L	Adult:>18_yrs_old	Both	Non-compensated hydrocephalics (pre-shunt implanted)	2611770
Cerebrospinal_Fluid(CSF)	2.50 (2.00-3.00)	umol/L	Adult:>18_yrs_old	Both	Degenerative disc disease	6656991


# Associated_Disorders:
Brain Edema; Cerebral Ischemia; Degenerative disc disease; Ischaemia; Lung Cancer; Non-compensated hydrocephalics (pre-shunt implanted); Self-compensated hydrocephalics

# Pathway_Names:
Purine metabolism;Nicotinate and nicotinamide metabolism

# Pathway_Images:
Purine_Synthesis.jpg;Nicotinamide_synthesis_(NADH).jpg

# KEGG_Images:
map00230;map00760

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;Nicotinamide_synthesis_(NADH)_Graph.jpg

# Pathway_SBMLs:
Purine_Synthesis.xml;Nicotinamide_synthesis_(NADH).xml

# Metabolic_Enzyme_1_ID:
5715

# Metabolic_Enzyme_1_Name:
Hypoxanthine-guanine phosphoribosyltransferase

# Metabolic_Enzyme_1_Synonyms:
HGPRT; HGPRTase

# Metabolic_Enzyme_1_Gene_Name:
HPRT1

# Metabolic_Enzyme_1_Protein_Sequence:
>Hypoxanthineguanine phosphoribosyltransferase
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA

# Metabolic_Enzyme_1_Number_of_Residues:
218

# Metabolic_Enzyme_1_Molecular_Weight:
24580

# Metabolic_Enzyme_1_Theoretical_pI:
6.67

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
Function:  hypoxanthine phosphoribosyltransferase activity
 ||
>>>
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  purine salvage
Process:  purine ribonucleoside salvage
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_1_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
IMP + diphosphate = hypoxanthine + 5-phospho- alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_1_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_1_Reaction:
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00156:Pribosyltran

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.2.8

# Metabolic_Enzyme_1_GenBank_ID_Protein:
306885

# Metabolic_Enzyme_1_SwissProt_ID:
HPRT_HUMAN (P00492)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
HPRT1

# Metabolic_Enzyme_1_Geneatlas_id:
HPRT1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:5157

# Metabolic_Enzyme_1_PDB_ID:
1BZY

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>657 bp
ATGGCGACCCGCAGCCCTGGCGTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGAT
TTATTTTGCATACCTAATCATTATGCTGAGGATTTGGAAAGGGTGTTTATTCCTCATGGA
CTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCAT
CACATTGTAGCCCTCTGTGTGCTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGAT
TACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACTGTAGATTTTATC
AGACTGAAGAGCTATTGTAATGACCAGTCAACAGGGGACATAAAAGTAATTGGTGGAGAT
GATCTCTCAACTTTAACTGGAAAGAATGTCTTGATTGTGGAAGATATAATTGACACTGGC
AAAACAATGCAGACTTTGCTTTCCTTGGTCAGGCAGTATAATCCAAAGATGGTCAAGGTC
GCAAGCTTGCTGGTGAAAAGGACCCCACGAAGTGTTGGATATAAGCCAGACTTTGTTGGA
TTTGAAATTCCAGACAAGTTTGTTGTAGGATATGCCCTTGACTATAATGAATACTTCAGG
GATTTGAATCATGTTTGTGTCATTAGTGAAACTGGAAAAGCAAAATACAAAGCCTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M31642

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_1_Locus:
Xq26.1

# Metabolic_Enzyme_1_SNPs:
rs17882614; rs17324664; rs1468266; rs6638240; rs6638244; rs629; rs12687175; rs2070888; rs17882706; rs17879768; rs6638243; rs6634993; rs2283774; rs2515695; rs17324671; rs17000619; rs17879343; rs17881098; rs17883992; rs17882148; rs6634992; rs17885981; rs17879832; rs17879883; rs17882974; rs17879054; rs6654281; rs17885745; rs17878776; rs17885116; rs17882408; rs17883944; rs17879655; rs17879788; rs17885487; rs17879062; rs12383909; rs17882655; rs6638248; rs17879889; rs6638241; rs17880246; rs17879587; rs12008402; rs17885587; rs17879537; rs17885351; rs17879338; rs17886003; rs17884897; rs17879126; rs17884671; rs17878519; rs17885249; rs17878726; rs17882575; rs630; rs17879579; rs17885481; rs17882577; rs17882724; rs17880173; rs17882449; rs17878366; rs17883719; rs17882059; rs17885063; rs17878341; rs17885117; rs17882713; rs17882954; rs17878494; rs17882387; rs17879006; rs17886404; rs17879389; rs17885867; rs17883942; rs17878843; rs17885455; rs17882760; rs17884775; rs6634990; rs6634995; rs17878582; rs17878883; rs17882358; rs17879110; rs17881011; rs35095771; rs41299094; rs17879494; rs17878772; rs11369747; rs12839009; rs17880167; rs17882944; rs17881023; rs374290; rs35009311; rs17883755; rs12861067; rs17882363; rs34425749; rs34838035; rs366687; rs6638242; rs17879610; rs28478865; rs17887208; rs405630; rs12380958; rs5903878; rs17878547; rs35869442; rs387714; rs35585686; rs6634994; rs17882487; rs17879085; rs5978009; rs5933415; rs17883196; rs116493; rs5933416; rs12836923; rs12381664; rs35238558; rs17882186; rs373901; rs35653185; rs17881003; rs6638245; rs35325865; rs35834777; rs11406107; rs17884978; rs17885259; rs17882884; rs17883708; rs12836918; rs391918; rs34619253; rs377106; rs35538011; rs17884910; rs398712; rs5933414; rs35832135; rs17885490; rs12381784; rs377103; rs5903877; rs17880051; rs12838998; rs17878536; rs11344152; rs2503983; rs36109224; rs17884854; rs17878792; rs17878589; rs7472760; rs28663133; rs117407; rs17881034; rs12381662; rs17886030; rs6638246; rs17885101; rs17879848; rs17879532; rs17882283; rs417522; rs17878403; rs414365; rs5978007; rs398716; rs7357883; rs10482430; rs12689866; rs12847109; rs437849; rs4829768; rs6634997; rs6638238

# Metabolic_Enzyme_1_General_References:
6300847; 2341149; 7107641; 3023844; 8044844; 10360366; 10338013; 1487231; 6853490; 6853716; 6572373; 6706936; 3358423; 3384338; 3265398; 2896620; 3198771; 3148064; 2572141; 2909537; 2910902; 2738157; 2928313; 2347587; 2358296; 2246854; 2018042; 2071157; 1937471; 1840476; 1551676; 1301916; 7627191; 9003484; 9452051

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5413

# Metabolic_Enzyme_2_Name:
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase

# Metabolic_Enzyme_2_Synonyms:
XD; Xanthine oxidase; XO; Xanthine oxidoreductase]

# Metabolic_Enzyme_2_Gene_Name:
XDH

# Metabolic_Enzyme_2_Protein_Sequence:
>Xanthine dehydrogenase/oxidase Includes: Xanthine dehydrogenase
MTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDR
LQNKIVHFSANACLAPICSLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGI
VMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNCC
MNQKKDHSVSLSPSLFKPEEFTPLDPTQEPIFPPELLRLKDTPRKQLRFEGERVTWIQAS
TLKELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFG
AACPLSIVEKTLVDAVAKLPAQKTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISD
LNPVFMASGAKLTLVSRGTRRTVQMDHTFFPGYRKTLLSPEEILLSIEIPYSREGEYFSA
FKQASRREDDIAKVTSGMRVLFKPGTTEVQELALCYGGMANRTISALKTTQRQLSKLWKE
ELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKLGQENLEDKCGKLD
PTFASATLLFQKDPPADVQLFQEVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDDIPRY
ENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSNITGICNDETVFAKDK
VTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSFYGPELKIEKGDL
KKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKM
LGVPANRIVVRVKRMGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGR
HPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPNIRGTGR
LCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLTHFNQKL
EGFTLPRCWEECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGA
LLHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAA
SVSADLNGQAVYAACQTILKRLEPYKKKNPSGSWEDWVTAAYMDTVSLSATGFYRTPNLG
YSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAF
VQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKAV
GEPPLFLAASIFFAIKDAIRAARAQHTGNNVKELFRLDSPATPEKIRNACVDKFTTLCVT
GVPENCKPWSVRV

# Metabolic_Enzyme_2_Number_of_Residues:
1333

# Metabolic_Enzyme_2_Molecular_Weight:
146426

# Metabolic_Enzyme_2_Theoretical_pI:
7.70

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  transporter activity
Function:  electron transporter activity
Function:  binding
Function:  ion binding
Function:  metal ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
This enzyme can be converted from the dehydrogenase form (D) to the oxidase form (O) irreversibly by proteolysis or reversibly through the oxidation of sulfhydryl groups

# Metabolic_Enzyme_2_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_2_Reaction:
xanthine + H2O + O2 = urate + H2O2

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01315:Ald_Xan_dh_C;
PF02738:Ald_Xan_dh_C2;
PF03450:CO_deh_flav_C;
PF00941:FAD_binding_5;
PF00111:Fer2;
PF01799:Fer2_2

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.17.1.4;EC 1.17.3.2

# Metabolic_Enzyme_2_GenBank_ID_Protein:
10336525

# Metabolic_Enzyme_2_SwissProt_ID:
XDH_HUMAN (P47989)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
XDH

# Metabolic_Enzyme_2_Geneatlas_id:
XDH

# Metabolic_Enzyme_2_hgnc_id:
HGNC:12805

# Metabolic_Enzyme_2_PDB_ID:
1V97

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_2_Gene_Sequence:
>4002 bp
ATGACAGCAGACAAATTGGTTTTCTTTGTGAATGGCAGAAAGGTGGTGGAGAAAAATGCA
GATCCAGAGACAACCCTTTTGGCCTACCTGAGAAGAAAGTTGGGGCTGAGTGGAACCAAG
CTCGGCTGTGGAGAGGGGGGCTGCGGGGCTTGCACAGTGATGCTCTCCAAGTATGATCGT
CTGCAGAACAAGATCGTCCACTTTTCTGCCAATGCCTGCCTGGCCCCCATCTGCTCCTTG
CACCATGTTGCAGTGACAACTGTGGAAGGAATAGGAAGCACCAAGACGAGGCTGCATCCT
GTGCAGGAGAGAATTGCCAAAAGCCACGGCTCCCAGTGCGGGTTCTGCACCCCTGGCATC
GTCATGAGTATGTACACACTGCTCCGGAATCAGCCCGAGCCCACCATGGAGGAGATTGAG
AATGCCTTCCAAGGAAATCTGTGCCGCTGCACAGGCTACAGACCCATCCTCCAGGGCTTC
CGGACCTTTGCCAGGGATGGTGGATGCTGTGGAGGAGATGGGAATAATCCAAATTGCTGC
ATGAACCAGAAGAAAGACCACTCAGTCAGCCTCTCGCCATCTTTATTCAAACCAGAGGAG
TTCACGCCCCTGGATCCAACCCAGGAGCCCATTTTTCCCCCAGAGTTGCTGAGGCTGAAA
GACACTCCTCGGAAGCAGCTGCGATTTGAAGGGGAGCGTGTGACGTGGATACAGGCCTCA
ACCCTCAAGGAGCTGCTGGACCTCAAGGCTCAGCACCCTGACGCCAAGCTGGTCGTGGGG
AACACGGAGATTGGCATTGAGATGAAGTTCAAGAATATGCTGTTTCCTATGATTGTCTGC
CCAGCCTGGATCCCTGAGCTGAATTCGGTAGAACATGGACCCGACGGTATCTCCTTTGGA
GCTGCTTGCCCCCTGAGCATTGTGGAAAAAACCCTGGTGGATGCTGTTGCTAAGCTTCCT
GCCCAAAAGACAGAGGTGTTCAGAGGGGTCCTGGAGCAGCTGCGCTGGTTTGCTGGGAAG
CAAGTCAAGTCTGTGGCGTCCGTTGGAGGGAACATCATCACTGCCAGCCCCATCTCCGAC
CTCAACCCCGTGTTCATGGCCAGTGGGGCCAAGCTGACACTTGTGTCCAGAGGCACCAGG
AGAACTGTCCAGATGGACCACACCTTCTTCCCTGGCTACAGAAAGACCCTGCTGAGCCCG
GAGGAGATACTGCTCTCCATAGAGATCCCCTACAGCAGGGAGGGGGAGTATTTCTCAGCA
TTCAAGCAGGCCTCCCGGAGAGAAGATGACATTGCCAAGGTAACCAGTGGCATGAGAGTT
TTATTCAAGCCAGGAACCACAGAGGTACAGGAGCTGGCCCTTTGCTATGGTGGAATGGCC
AACAGAACCATCTCAGCCCTCAAGACCACTCAGAGGCAGCTTTCCAAGCTCTGGAAGGAG
GAGCTGCTGCAGGACGTGTGTGCAGGACTGGCAGAGGAGCTGCATCTGCCTCCCGATGCC
CCTGGTGGCATGGTGGACTTCCGGTGCACCCTCACCCTCAGCTTCTTCTTCAAGTTCTAC
CTGACAGTCCTTCAGAAGCTGGGCCAAGAGAACCTGGAAGACAAGTGTGGTAAACTGGAC
CCCACTTTCGCCAGTGCAACTTTACTGTTTCAGAAAGACCCCCCAGCCGATGTCCAGCTC
TTCCAAGAGGTGCCCAAGGGTCAGTCTGAGGAGGACATGGTGGGCCGGCCCCTGCCCCAC
CTGGCAGCGGACATGCAGGCCTCTGGTGAGGCCGTGTACTGTGACGACATTCCTCGCTAC
GAGAATGAGCTGTCTCTCCGGCTGGTCACCAGCACCCGGGCCCACGCCAAGATCAAGTCC
ATAGATACATCAGAAGCTAAGAAGGTTCCAGGGTTTGTTTGTTTCATTTCCGCTGATGAT
GTTCCTGGGAGTAACATAACTGGAATTTGTAATGATGAGACAGTCTTTGCGAAGGATAAG
GTTACTTGTGTTGGGCATATCATTGGTGCTGTGGTTGCTGACACCCCGGAACACACACAG
AGAGCTGCCCAAGGGGTGAAAATCACCTATGAAGAACTACCAGCCATTATCACAATTGAG
GATGCTATAAAGAACAACTCCTTTTATGGACCTGAGCTGAAGATCGAGAAAGGGGACCTA
AAGAAGGGGTTTTCCGAAGCAGATAATGTTGTGTCAGGGGAGATATACATCGGTGGCCAA
GAGCACTTCTACCTGGAGACTCACTGCACCATTGCTGTTCCAAAAGGCGAGGCAGGGGAG
ATGGAGCTCTTTGTGTCTACACAGAACACCATGAAGACCCAGAGCTTTGTTGCAAAAATG
TTGGGGGTTCCAGCAAACCGGATTGTGGTTCGAGTGAAGAGAATGGGAGGAGGCTTTGGA
GGCAAGGAGACCCGGAGCACTGTGGTGTCCACGGCAGTGGCCCTGGCTGCATATAAGACC
GGCCGCCCTGTGCGATGCATGCTGGACCGTGATGAGGACATGCTGATAACTGGTGGCAGA
CATCCCTTCCTGGCCAGATACAAGGTTGGCTTCATGAAGACTGGGACAGTTGTGGCTCTT
GAGGTGGACCACTTCAGCAATGTGGGGAACACCCAGGATCTCTCTCAGAGTATTATGGAA
CGAGCTTTATTCCACATGGACAACTGCTATAAAATCCCCAACATCCGGGGCACTGGGCGG
CTGTGCAAAACCAACCTTCCCTCCAACACGGCCTTCCGGGGCTTTGGGGGGCCCCAGGGG
ATGCTCATTGCCGAGTGCTGGATGAGTGAAGTTGCAGTGACCTGTGGGATGCCTGCAGAG
GAGGTGCGGAGAAAAAACCTGTACAAAGAAGGGGACCTGACACACTTCAACCAGAAGCTT
GAGGGTTTCACCTTGCCCAGATGCTGGGAAGAATGCCTAGCAAGCTCTCAGTATCATGCT
CGGAAGAGTGAGGTTGACAAGTTCAACAAGGAGAATTGTTGGAAAAAGAGAGGATTGTGC
ATAATTCCCACCAAGTTTGGAATAAGCTTCACAGTTCCTTTTCTGAATCAGGCAGGAGCC
CTACTTCATGTGTACACAGATGGCTCTGTGCTGCTGACCCACGGGGGGACTGAGATGGGC
CAAGGCCTTCATACCAAAATGGTCCAGGTGGCCAGTAGAGCTCTGAAAATCCCCACCTCT
AAGATTTATATCAGCGAGACAAGCACTAACACTGTGCCCAACACCTCTCCCACGGCTGCC
TCTGTCAGCGCTGACCTCAATGGACAGGCCGTCTATGCGGCTTGTCAGACCATCTTGAAA
AGGCTGGAACCCTACAAGAAGAAGAATCCCAGTGGCTCCTGGGAAGACTGGGTCACAGCT
GCCTACATGGACACAGTGAGCTTGTCTGCCACTGGGTTTTATAGAACACCCAATCTGGGC
TACAGCTTTGAGACTAACTCAGGGAACCCCTTCCACTACTTCAGCTATGGGGTGGCTTGC
TCTGAAGTAGAAATCGACTGCCTAACAGGAGATCATAAGAACCTCCGCACAGATATTGTC
ATGGATGTTGGCTCCAGTCTAAACCCTGCCATTGATATTGGACAGGTGGAAGGGGCATTT
GTCCAGGGCCTTGGCCTCTTCACCCTAGAGGAGCTACACTATTCCCCCGAGGGGAGCCTG
CACACCCGTGGCCCTAGCACCTACAAGATCCCGGCATTTGGCAGCATCCCCATTGAGTTC
AGGGTGTCCCTGCTCCGCGACTGCCCCAACAAGAAGGCCATCTATGCATCGAAGGCTGTT
GGAGAGCCGCCCCTCTTCCTGGCTGCTTCTATCTTCTTTGCCATCAAAGATGCCATCCGT
GCAGCTCGAGCTCAGCACACAGGTAATAACGTGAAGGAACTCTTCCGGCTAGACAGCCCT
GCCACCCCGGAGAAGATCCGCAATGCCTGCGTGGACAAGTTCACCACCCTGTGTGTCACT
GGTGTCCCAGAAAACTGCAAACCCTGGTCTGTGAGGGTCTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
D11456

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_2_Locus:
2p23.1

# Metabolic_Enzyme_2_SNPs:
rs17011368; rs17323225; rs34929837; rs1884725; rs2295475; rs4407290; rs207440; rs1042039; rs6752058; rs6710015; rs1054889; rs1896846; rs206857; rs1366814; rs206858; rs1429372; rs1991541; rs761926; rs2195502; rs169596; rs206847; rs2365842; rs1429376; rs206811; rs6714794; rs2281549; rs992137; rs13387204; rs2163059; rs2070293; rs206798; rs206846; rs1366811; rs10184437; rs12621192; rs2281550; rs206805; rs992138; rs6543628; rs732436; rs6720163; rs207454; rs994727; rs1864280; rs11900892; rs206804; rs1366812; rs1346644; rs3769618; rs207448; rs6733391; rs4952088; rs3820922; rs1429374; rs206797; rs206860; rs4952085; rs206855; rs513311; rs1018505; rs206859; rs7574920; rs2281548; rs206803; rs206801; rs1594158; rs206854; rs743163; rs6718606; rs1835171; rs206800; rs206849; rs11885410; rs13418515; rs2073316; rs2749994; rs2018410; rs2010704; rs13414618; rs11904439; rs12618694; rs11124259; rs17011353; rs4952083; rs1366817; rs10170372; rs11124258; rs11895133; rs12712315; rs2268800; rs2043013; rs2070294; rs4952084; rs494852; rs7582523; rs207444; rs7597755; rs206802; rs13398137; rs206856; rs206799; rs206848; rs2281547; rs17011356; rs10171290; rs4951978; rs10199855; rs1594160; rs7583694; rs2749998; rs9308919; rs11889858; rs17011403; rs4549138; rs473935; rs12712316; rs7557095; rs10190201; rs207452; rs185925; rs561525; rs206810; rs13415401; rs6760292; rs12614330; rs732437; rs17038412; rs10175754; rs2268801; rs1978638; rs6717626; rs528551; rs4952086; rs2273452; rs207436; rs206851; rs17011359; rs2236168; rs7574484; rs7558538; rs17011401; rs207445; rs206806; rs13419410; rs1579464; rs11894627; rs207449; rs4952087; rs13011035; rs7578359; rs13431382; rs566224; rs7595188; rs1896844; rs1366813; rs11899710; rs10174527; rs17395224; rs11693761; rs1978639; rs9973789; rs207451; rs7558472; rs7571290; rs207441; rs7598968; rs4952239; rs17395161; rs1896845; rs11678319; rs7599175; rs3769616; rs207455; rs206808; rs11680208; rs10187719; rs6759319; rs1835170; rs17395175; rs11895512; rs17011365; rs12478183; rs7572658; rs2284831; rs206812; rs6543626; rs206813; rs12474363; rs669884; rs1042036; rs1126469; rs566362; rs2295474; rs36208390; rs10590467; rs35595791; rs34256084; rs28512450; rs13408033; rs35506664; rs4951980; rs35408744; rs34572527; rs34228932; rs206807; rs35059671; rs207442; rs477626; rs13026261; rs28600110; rs35626926; rs13397122; rs34575198; rs207446; rs207453; rs10616678; rs11268251; rs35646405; rs11302270; rs6708664; rs28412138; rs207439; rs35235275; rs35526028; rs7424583; rs35096086; rs3835888; rs35188315; rs11408029; rs13419594; rs12614895; rs11323608; rs34278988; rs10188919; rs10546630; rs35134558; rs13430476; rs4496369; rs13409029; rs28469567; rs12615273; rs207450; rs35645044; rs1884724; rs34183875; rs35575779; rs13009701; rs10599864; rs2217367; rs10084228; rs10172747; rs34365088; rs206850; rs207438; rs34200607; rs13419527; rs10614879; rs12478123; rs7583231; rs3216622; rs35990837; rs35510476; rs10172304; rs34817436; rs1366816; rs11465197; rs566250; rs6711552; rs206809; rs34352561; rs207447; rs10188839; rs2236169; rs35519594; rs1072012; rs34172577; rs7597682; rs13421730; rs2195501; rs35353013; rs13382306; rs13384006; rs13420013; rs13423453; rs11893429; rs4645042; rs34585315; rs35088687; rs34391765; rs7571426; rs10181969; rs7583496; rs207401; rs2145035; rs1594159; rs34526484; rs11280611; rs35597832; rs34563075; rs36069447; rs13009347; rs9973790; rs28706043; rs206852; rs10684869; rs7571721; rs6753620; rs35796160; rs41280623; rs35998157; rs34791092; rs35466291; rs6709675; rs34525014; rs34801507; rs35743236; rs34390422; rs10169844; rs35759405; rs13426715; rs12465856; rs1429375; rs28493055; rs35310413; rs207443; rs9973791; rs4952089; rs34272551; rs35724511; rs35234764; rs11888439; rs36208393; rs6744073; rs11695571; rs207435; rs36208714; rs9712309; rs743161; rs36208715; rs754918; rs743162; rs10164462; rs10204686; rs10490361; rs11677908; rs11678012; rs12469115; rs12478111; rs13028511; rs13392979; rs188260; rs206814; rs206815; rs206816; rs206817; rs206818; rs207424; rs207425; rs207426; rs207427; rs207428; rs207429; rs207431; rs207432; rs207433; rs207434; rs34433526; rs4952236; rs635581; rs6742051; rs736492; rs7558797; rs7575607; rs932559

# Metabolic_Enzyme_2_General_References:
8224915; 8135849; 7575623; 8670112

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5806

# Metabolic_Enzyme_3_Name:
Thymidine phosphorylase precursor

# Metabolic_Enzyme_3_Synonyms:
TdRPase; TP; Platelet-derived endothelial cell growth factor; PD-ECGF; Gliostatin

# Metabolic_Enzyme_3_Gene_Name:
ECGF1

# Metabolic_Enzyme_3_Protein_Sequence:
>Thymidine phosphorylase precursor
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ

# Metabolic_Enzyme_3_Number_of_Residues:
482

# Metabolic_Enzyme_3_Molecular_Weight:
49956

# Metabolic_Enzyme_3_Theoretical_pI:
5.19

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  pyrimidine base metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_3_Reaction:
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF02885:Glycos_trans_3N;
PF00591:Glycos_transf_3;
PF07831:PYNP_C

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.4.2.4

# Metabolic_Enzyme_3_GenBank_ID_Protein:
189701

# Metabolic_Enzyme_3_SwissProt_ID:
TYPH_HUMAN (P19971)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ECGF1

# Metabolic_Enzyme_3_Geneatlas_id:
ECGF1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:3148

# Metabolic_Enzyme_3_PDB_ID:
1UOU

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>1449 bp
ATGGCAGCCTTGATGACCCCGGGAACCGGGGCCCCACCCGCGCCTGGTGACTTCTCCGGG
GAAGGGAGCCAGGGACTTCCCGACCCTTCGCCAGAGCCCAAGCAGCTCCCGGAGCTGATC
CGCATGAAGCGAGACGGAGGCCGCCTGAGCGAAGCGGACATCAGGGGCTTCGTGGCCGCT
GTGGTGAATGGGAGCGCGCAGGGCGCACAGATCGGGGCCATGCTGATGGCCATCCGACTT
CGGGGCATGGATCTGGAGGAGACCTCGGTGCTGACCCAGGCCCTGGCTCAGTCGGGACAG
CAGCTGGAGTGGCCAGAGGCCTGGCGCCAGCAGCTTGTGGACAAGCATTCCACAGGGGGT
GTGGGTGACAAGGTCAGCCTGGTCCTCGCACCTGCCCTGGCGGCATGTGGCTGCAAGGTG
CCAATGATCAGCGGACGTGGTCTGGGGCACACAGGAGGCACCTTGGATAAGCTGGAGTCT
ATTCCTGGATTCAATGTCATCCAGAGCCCAGAGCAGATGCAAGTGCTGCTGGACCAGGCG
GGCTGCTGTATCGTGGGTCAGAGTGAGCAGCTGGTTCCTGCGGACGGAATCCTATATGCA
GCCAGAGATGTGACAGCCACCGTGGACAGCCTGCCACTCATCACAGCCTCCATTCTCAGT
AAGAAACTCGTGGAGGGGCTGTCCGCTCTGGTGGTGGACGTTAAGTTCGGAGGGGCCGCC
GTCTTCCCCAACCAGGAGCAGGCCCGGGAGCTGGCAAAGACGCTGGTTGGCGTGGGAGCC
AGCCTAGGGCTTCGGGTCGCGGCAGCGCTGACCGCCATGGACAAGCCCCTGGGTCGCTGC
GTGGGCCACGCCCTGGAGGTGGAGGAGGCGCTGCTCTGCATGGACGGCGCAGGCCCGCCA
GACTTAAGGGACCTGGTCACCACGCTCGGGGGCGCCCTGCTCTGGCTCAGCGGACACGCG
GGGACTCAGGCTCAGGGCGCTGCCCGGGTGGCCGCGGCGCTGGACGACGGCTCGGCCCTT
GGCCGCTTCGAGCGGATGCTGGCGGCGCAGGGCGTGGATCCCGGTCTGGCCCGAGCCCTG
TGCTCGGGAAGTCCCGCAGAACGCCGGCAGCTGCTGCCTCGCGCCCGGGAGCAGGAGGAG
CTGCTGGCGCCCGCAGATGGCACCGTGGAGCTGGTCCGGGCGCTGCCGCTGGCGCTGGTG
CTGCACGAGCTCGGGGCCGGGCGCAGCCGCGCTGGGGAGCCGCTCCGCCTGGGGGTGGGC
GCAGAGCTGCTGGTCGACGTGGGTCAGAGGCTGCGCCGTGGGACCCCCTGGCTCCGCGTG
CACCGGGACGGCCCCGCGCTCAGCGGCCCGCAGAGCCGCGCCCTGCAGGAGGCGCTCGTA
CTCTCCGACCGCGCGCCATTCGCCGCCCCCTCGCCCTTCGCAGAGCTCGTTCTGCCGCCG
CAGCAATAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M63193

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_3_Locus:
22q13|22q13.33

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
2467210; 1570012; 1400349; 1590793; 9924029; 12177387

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5805

# Metabolic_Enzyme_4_Name:
Purine nucleoside phosphorylase

# Metabolic_Enzyme_4_Synonyms:
Inosine phosphorylase; PNP

# Metabolic_Enzyme_4_Gene_Name:
NP

# Metabolic_Enzyme_4_Protein_Sequence:
>Purine nucleoside phosphorylase
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS

# Metabolic_Enzyme_4_Number_of_Residues:
289

# Metabolic_Enzyme_4_Molecular_Weight:
32118

# Metabolic_Enzyme_4_Theoretical_pI:
6.95

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  purine-nucleoside phosphorylase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_4_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_4_Reaction:
purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00896:Mtap_PNP

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.4.2.1

# Metabolic_Enzyme_4_GenBank_ID_Protein:
35565

# Metabolic_Enzyme_4_SwissProt_ID:
PNPH_HUMAN (P00491)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
NP

# Metabolic_Enzyme_4_Geneatlas_id:
NP

# Metabolic_Enzyme_4_hgnc_id:
HGNC:7892

# Metabolic_Enzyme_4_PDB_ID:
1RT9

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>870 bp
ATGGAGAACGGATACACCTATGAAGATTATAAGAACACTGCAGAATGGCTTCTGTCTCAT
ACTAAGCACCGACCTCAAGTTGCAATAATCTGTGGTTCTGGATTAGGAGGTCTGACTGAT
AAATTAACTCAGGCCCAGATCTTTGACTACAGTGAAATCCCCAACTTTCCTCGAAGTACA
GTGCCAGGTCATGCTGGCCGACTGGTGTTTGGGTTCCTGAATGGCAGGGCCTGTGTGATG
ATGCAGGGCAGGTTCCACATGTATGAAGGGTACCCACTCTGGAAGGTGACATTCCCAGTG
AGGGTTTTCCACCTTCTGGGTGTGGACACCCTGGTAGTCACCAATGCAGCAGGAGGGCTG
AACCCCAAGTTTGAGGTTGGAGATATCATGCTGATCCGTGACCATATCAACCTACCTGGT
TTCAGTGGTCAGAACCCTCTCAGAGGGCCCAATGATGAAAGGTTTGGAGATCGTTTCCCT
GCCATGTCTGATGCCTACGACCGGACTATGAGGCAGAGGGCTCTCAGTACCTGGAAACAA
ATGGGGGAGCAACGTGAGCTACAGGAAGGCACCTATGTGATGGTGGCAGGCCCCAGCTTT
GAGACTGTGGCAGAATGTCGTGTGCTGCAGAAGCTGGGAGCAGACGCTGTTGGCATGAGT
ACAGTACCAGAAGTTATCGTTGCACGGCACTGTGGACTTCGAGTCTTTGGCTTCTCACTC
ATCACTAACAAGGTCATCATGGATTATGAAAGCCTGGAGAAGGCCAACCATGAAGAAGTC
TTAGCAGCTGGCAAACAAGCTGCACAGAAATTGGAACAGTTTGTCTCCATTCTTATGGCC
AGCATTCCACTCCCTGACAAAGCCAGTTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
X00737

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_4_Locus:
14q13.1

# Metabolic_Enzyme_4_SNPs:
rs1049564; rs1130650; rs1049562; rs7785; rs1617940; rs1760940; rs1713420; rs1760935; rs1713422; rs1713421; rs3790064; rs3790065; rs1713429; rs17882804; rs17880405; rs1756369; rs12147688; rs8008133; rs17881431; rs17881345; rs7154909; rs17883821; rs17885781; rs1760934; rs17879107; rs17880844; rs17879913; rs17881184; rs17885714; rs17880480; rs17883253; rs17878900; rs1713426; rs17881356; rs1713427; rs1760933; rs3790062; rs17883795; rs17112168; rs17880290; rs12147906; rs17881554; rs17881206; rs1049700; rs17882836; rs12101049; rs17884106; rs12147035; rs34480769; rs3838361; rs3842517; rs1760939; rs17885917; rs17886095; rs1760938; rs17883294; rs17883604; rs8019880; rs17881280; rs35549071; rs35139440; rs17880503; rs7151666; rs10498268; rs1079375; rs1079376; rs11846743; rs11850059; rs11850069; rs12587218; rs12886203; rs12888804; rs12891271; rs13379232; rs13379234; rs1629478; rs17112384; rs17112385; rs1713459; rs1713460; rs1713461; rs1713462; rs17242655; rs17242662; rs17242669; rs1756365; rs1760930; rs1760931; rs1760941; rs1760942; rs2077153; rs2481768; rs35175606; rs35567022; rs7156659; rs755777

# Metabolic_Enzyme_4_General_References:
6087295; 3029074; 12928150; 2104852; 1384322; 8931706

# Metabolic_Enzyme_4_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7803

# Macromolecular_Interacting_Partner_1_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_1_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_1_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_1_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_1_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_1_References:
15013074; 15829228

# Macromolecular_Interacting_Partner_2_ID:
8341

# Macromolecular_Interacting_Partner_2_Name:
DNA-3-methyladenine glycosylase

# Macromolecular_Interacting_Partner_2_Synonyms:
3-methyladenine DNA glycosidase; ADPG; 3-alkyladenine DNA glycosylase; N-methylpurine- DNA glycosylase

# Macromolecular_Interacting_Partner_2_Gene_Name:
MPG

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>DNA3methyladenine glycosylase
MVTPALQMKKPKQFCRRMGQKKQRPARAGQPHSSSDAAQAPAEQPHSSSDAAQAPCPRER
CLGPPTTPGPYRSIYFSSPKGHLTRLGLEFFDQPAVPLARAFLGQVLVRRLPNGTELRGR
IVETEAYLGPEDEAAHSRGGRQTPRNRGMFMKPGTLYVYIIYGMYFCMNISSQGDGACVL
LRALEPLEGLETMRHVRSTLRKGTASRVLKDRELCSGPSKLCQALAINKSFDQRDLAQDE
AVWLERGPLEPSEPAVVAAARVGVGHAGEWARKPLRFYVRGSPWVSVVDRVAEQDTQA

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
298

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
32864

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
10.00

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing N-glycosyl compounds
Function:  DNA N-glycosylase activity
Function:  alkylbase DNA N-glycosylase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  DNA metabolism
Process:  DNA repair
Process:  base-excision repair
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Replication, recombination and repair 

# Macromolecular_Interacting_Partner_2_Specific_Function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF02245:Pur_DNA_glyco

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
EC 3.2.2.21

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
183769

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
3MG_HUMAN (P29372)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
MPG

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
MPG

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:7211

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Nucleus (Potential)

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>897 bp
ATGGTCACCCCCGCTTTGCAGATGAAGAAACCAAAGCAGTTTTGCCGACGGATGGGGCAA
AAGAAGCAGCGACCAGCTAGAGCAGGGCAGCCACACAGCTCGTCCGACGCAGCCCAGGCA
CCTGCAGAGCAGCCACACAGCTCGTCCGATGCAGCCCAGGCACCTTGCCCCAGGGAGCGC
TGCTTGGGACCGCCCACCACTCCGGGCCCATACCGCAGCATCTATTTCTCAAGCCCAAAG
GGCCACCTTACCCGACTGGGGTTGGAGTTCTTCGACCAGCCGGCAGTCCCCCTGGCCCGG
GCATTTCTGGGACAGGTCCTAGTCCGGCGACTTCCTAATGGCACAGAACTCCGAGGCCGC
ATCGTGGAGACCGAGGCATACCTGGGGCCAGAGGATGAACCGGCCCACTCAAGGGGTGGC
CGGCAGACCCCCCGCAACCGAGGCATGTTCATGAAGCCGGGGACCCTGTACGTGTACATC
ATTTACGGCATGTACTTCTGCATGAACATCTCCAGCCAGGGGGACGGGGCTTGCGTCTTG
CTGCGAGCACTGGAGCCCCTGGAAGGTCTGGAGACCATGCGTCACGTTCGCAGCACCCTC
CGGAAAGGCACCGCCAGCCGTGTCCTCAAGGACCGCGAGCTCTGCAGTGGCCCCTCCAAG
CTGTGCCAGGCCCTGGCCATCAACAAGAGCTTTGACCAGAGGGACCTGGCACAGGATGAA
GCTGTATGGCTGGAGCGTGGTCCCCTGGAGCCCAGTGAGCCGGCTGTAGTGGCAGCAGCC
CGGGTGGGCGTCGGCCATGCAGGGGAGTGGGCCCGGAAACCCCTCCGCTTCTATGTCCGG
GGCAGCCCCTGGGTCAGTGTGGTCGACAGAGTGGCTGAGCAGGACACACAGGCCTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M74905

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_2_Locus:
16p13.3

# Macromolecular_Interacting_Partner_2_SNPs:
rs2266607; rs2308313; rs2308312; rs3176383; rs2266605; rs2266606; rs3176388; rs710080; rs710079; rs1013358; rs3176368; rs3176370; rs3176371; rs3176373; rs3176364; rs3785288; rs2234890; rs3176380; rs3176369; rs3176366; rs3176367; rs2562162; rs1318634; rs3056231; rs3176406; rs2562182; rs3176403; rs2858056; rs2541633; rs2266608; rs8061847; rs1061438; rs2541632; rs3176398; rs3176424; rs2858049; rs1061435; rs3176411; rs2541634; rs2858050; rs2541624; rs3021149; rs2858047; rs3176389; rs12919203; rs3176396; rs3176421; rs12920952; rs12919210; rs3176422; rs2541627; rs3176395; rs3176397; rs2541630; rs11644979; rs7200253; rs2909029; rs3176415; rs3176401; rs3176392; rs3176391; rs2562183; rs8047518; rs2541625; rs12933457; rs2858046; rs11643928; rs3176400; rs3176399; rs8061816; rs3176423; rs2541635; rs34688273; rs17398811; rs2308315; rs4986985; rs2308314; rs3176376; rs17137102; rs3176382; rs3176372; rs35812834; rs3176365; rs35321604; rs34006687; rs3176374; rs12925736; rs35397107; rs3176362; rs13338334; rs12925728; rs3176363; rs3176394; rs2858045; rs8061805; rs12929761; rs3176405; rs2541631; rs34591909; rs12933440; rs3176426; rs34532333; rs28373490; rs3176417; rs12935411; rs2914516; rs12929592; rs2541626; rs7195385; rs12445983; rs12919046; rs3176416; rs2541629; rs12933446; rs3176412; rs3176407; rs2914517; rs2562184; rs3176428; rs36126402; rs3176430; rs3176393; rs3176427; rs2541628; rs3176419; rs7203971; rs35524599; rs11643812; rs2909030; rs3176410; rs3176402; rs34584549; rs2562157; rs34456770; rs2562160; rs12925827; rs12929271; rs12929395; rs2562159; rs11390587; rs2562161; rs12931208; rs2562158; rs1050764; rs10751767; rs216606; rs216607; rs216608; rs216609; rs216610; rs216611; rs216612; rs216613; rs216614; rs2234949; rs2238365; rs2239296; rs2239297; rs2259275; rs2541618; rs2541619; rs2541622; rs2541623; rs2562151; rs2562152; rs2562153; rs2562154; rs2562155; rs2562156; rs2562177; rs2562181; rs2858048; rs3176434; rs3176435; rs3176437; rs3176440; rs3826235; rs6600233; rs7185192; rs743725; rs769191; rs769193; rs878380; rs878381; rs880482; rs891145; rs9929721; rs9936565

# Macromolecular_Interacting_Partner_2_General_References:
1924375; 8475094; 11157797; 1874728; 1645538; 8318735; 9790531

# Macromolecular_Interacting_Partner_2_References:
14761960

# Macromolecular_Interacting_Partner_3_ID:
8758

# Macromolecular_Interacting_Partner_3_Name:
Equilibrative nucleoside transporter 2

# Macromolecular_Interacting_Partner_3_Synonyms:
Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter; Equilibrative NBMPR-insensitive nucleoside transporter; Nucleoside transporter, ei-type; Solute carrier family 29 member 2; 36 kDa nucleolar protein HNP36; Hydrophobic nucleolar protein, 36 kDa; Delayed-early response protein 12

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC29A2

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Equilibrative nucleoside transporter 2
MARGDAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGNSTARILSTNHTG
PEDAFNFNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGSLLAILLLFALTAALVKVD
MSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLL
SMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQELETKAE
LLQSDENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLV
FTVTLSVFPAITAMVTSSTSPGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRL
LPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPR
QVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
456

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
50114

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.02

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
 Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_3_Signals:
1-24

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
13-33
70-90
99-119
124-144
162-182
193-213
291-311
324-344
360-380
386-406
432-452

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
2811137

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
S29A2_HUMAN (Q14542)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC29A2

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC29A2

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:11004

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Isoform 1:Cell membrane; multi-pass membrane protein. Isoform 2:Nucleus; nuclear membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1371 bp
ATGGCGCGAGGAGACGCCCCGCGGGACAGCTACCACCTGGTCGGGATCAGCTTCTTCATC
CTGGGGCTGGGCACCCTCCTTCCCTGGAACTTCTTCATCACCGCCATCCCGTACTTCCAG
GCGCGACTGGCCGGGGCCGGCAACAGCACAGCCAGGATCCTGAGCACCAACCACACGGGT
CCCGAGGATGCCTTCAACTTCAACAATTGGGTGACGCTGCTGTCCCAGCTGCCCCTGCTG
CTCTTCACCCTCCTCAACTCCTTCCTGTACCAGTGCGTCCCGGAGACGGTGCGCATTCTG
GGCAGCCTGCTGGCCATACTGCTGCTCTTTGCCCTGACAGCAGCGCTGGTCAAGGTGGAC
ATGAGCCCCGGACCCTTCTTCTCCATCACCATGGCCTCCGTCTGCTTCATCAACTCCTTC
AGTGCAGTCCTACAGGGCAGCCTCTTCGGGCAGCTGGGCACCATGCCCTCCACCTACAGC
ACCCTCTTCCTCAGCGGCCAGGGCCTGGCTGGGATCTTTGCTGCCCTTGCCATGCTCCTG
TCCATGGCCAGTGGCGTGGACGCCGAGACCTCTGCCCTGGGGTACTTTATCACGCCCTGT
GTGGGCATCCTCATGTCCATCGTGTGTTACCTGAGCCTGCCTCACCTGAAGTTTGCCCGC
TACTACCTGGCCAATAAATCATCCCAGGCCCAAGCTCAGGAGCTGGAGACCAAAGCTGAG
CTCCTCCAGTCTGATGAGAACGGGATTCCCAGTAGTCCCCAGAAAGTAGCTCTGACCCTG
GATCTTGACCTGGAGAAGGAGCCGGAATCAGAGCCAGATGAGCCCCAGAAGCCAGGAAAA
CCTTCAGTCTTCACTGTCTTCCAGAAGATCTGGCTGACAGCGCTGTGCCTTGTGTTGGTC
TTCACAGTCACCCTGTCCGTCTTCCCCGCCATCACAGCCATGGTGACCAGCTCCACCAGT
CCTGGGAAGTGGAGTCAGTTCTTCAACCCCATCTGCTGCTTCCTCCTCTTCAACATCATG
GACTGGCTGGGACGGAGCCTGACCTCTTACTTCCTGTGGCCAGACGAGGACAGCCGGCTG
CTGCCCCTGCTGGTCTGCCTGCGGTTCCTGTTCGTGCCCCTCTTCATGCTGTGCCACGTG
CCCCAGAGGTCCCGGCTGCCCATCCTCTTCCCACAGGATGCCTACTTCATCACCTTCATG
CTGCTCTTTGCCGTTTCTAATGGCTACCTGGTGTCCCTCACCATGTGCCTGGCGCCCAGG
CAGGTGCTGCCACACGAGAGGGAGGTGGCCGGCGCCCTCATGACCTTCTTCCTGGCCCTG
GGACTTTCCTGTGGAGCCTCCCTCTCCTTCCTCTTCAAGGCGCTGCTCTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF034102

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11q13

# Macromolecular_Interacting_Partner_3_SNPs:
rs8187661; rs1039593; rs3177514; rs4930358; rs7126064; rs2292123; rs2279861; rs2279862; rs7125100; rs7126018; rs12416747; rs1039594; rs10791872; rs8187658; rs3867130; rs12576299; rs1344410; rs12576293; rs12577196; rs4930178; rs4930359; rs12281049; rs4244813; rs7107191; rs7104297; rs17850744; rs17855425; rs12801227; rs34186490; rs34124904; rs11227466; rs4554890; rs3741366; rs10605893; rs11403442; rs7111197; rs10632640; rs35639157; rs35962792; rs7946434; rs33943132; rs34029417; rs1815807; rs35659701; rs7103571; rs35791794; rs10648232; rs11423263; rs34482391; rs1566871; rs11298226; rs12800796; rs35509820; rs11461356; rs35457397; rs1201452; rs1210071; rs34585457; rs12360603; rs1047029; rs10791871; rs12794121; rs34272485; rs7130857; rs8187644; rs8187646; rs8187647; rs8187657; rs8187659; rs8187660

# Macromolecular_Interacting_Partner_3_General_References:
9478986; 9396714; 7639753

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8857

# Macromolecular_Interacting_Partner_4_Name:
Equilibrative nucleoside transporter 3

# Macromolecular_Interacting_Partner_4_Synonyms:
Solute carrier family 29 member 3

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC29A3

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Equilibrative nucleoside transporter 3
MAVVSEDDFQHSSNSTYRTTSSSLRADQEALLEKLLDRPPPGLQRPEDRFCGTYIIFFSL
GIGSLLPWNFFITAKEYWMFKLRNSSSPATGEDPEGSDILNYFESYLAVASTVPSMLCLV
ANFLLVNRVAVHIRVLASLTVILAIFMVITALVKVDTFSWTRGFFAVTIVCMVILSGAST
VFSSSIYGMTGSFPMRNSQALISGGAMGGTVSAVASLVDLAASSDVRNSALAFFLTATIF
LVLCMGLYLLLSRLEYARYYMRPVLAAHVFSGEEELPQDSLSAPSVASRFIDSHTPPLRP
ILKKTASLGFCVTYVFFITSLIYPAVCTNIESLNKGSGSLWTTKFFIPLTTFLLYNFADL
CGRQLTAWIQVPGPNSKALPGFVLLRTCLIPLFVLCNYQPRVHLKTVVFQSDVYPALLSS
LLGLSNGYLSTLALLYGPKIVPRELAEATGVVMSFYVCLGLTLGSACSTLLVHLI

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
475

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
51875

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
7.85

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
 Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter)

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_4_Signals:
Not Available

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
50-72
107-126
131-153
163-185
198-220
230-252
308-330
340-357
378-395
415-437
450-472

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
12656639

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
S29A3_HUMAN (Q9BZD2)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC29A3

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC29A3

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:23096

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1428 bp
ATGGCCGTTGTCTCAGAGGACGACTTTCAGCACAGTTCAAACTCCACCTACAGAACCACA
AGCAGCAGTCTCCGAGCTGACCAGGAGGCACTGCTTGAGAAGCTGCTGGACCGCCCGCCC
CCTGGCCTGCAGAGGCCCGAGGACCGCTTCTGTGGCACATACATCATCTTCTTCAGCCTG
GGCATTGGCAGTCTACTGCCATGGAACTTCTTTATCACTGCCAAGGAGTACTGGATGTTC
AAACTCCGCAACTCCTCCAGCCCAGCCACCGGGGAGGACCCTGAGGGCTCAGACATCCTG
AACTACTTTGAGAGCTACCTTGCCGTTGCCTCCACCGTGCCCTCCATGCTGTGCCTGGTG
GCCAACTTCCTGCTTGTCAACAGGGTTGCAGTCCACATCCGTGTCCTGGCCTCACTGACG
GTCATCCTGGCCATCTTCATGGTGATAACTGCACTGGTGAAGGTGGACACTTTCTCCTGG
ACCCGTGGCTTTTTTGCGGTCACCATTGTCTGCATGGTGATCCTCAGCGGTGCCTCCACT
GTCTTCAGCAGCAGCATCTACGGCATGACCGGCTCCTTTCCTATGAGGAACTCCCAGGCA
CTGATATCAGGAGGAGCCATGGGCGGGACGGTCAGCGCCGTGGCCTCATTGGTGGACTTG
GCTGCATCCAGTGATGTGAGGAACAGCGCCCTGGCCTTCTTCCTGACGGCCACCATCTTC
CTCGTGCTCTGCATGGGACTCTACCTGCTGCTGTCCAGGCTGGAGTATGCCAGGTACTAC
ATGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGAAGAGGAGCTTCCCCAGGACTCC
CTCAGTGCCCCTTCGGTGGCCTCCAGATTCATTGATTCCCACACACCCCCTCTCCGCCCC
ATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGTCTTCTTCATCACCAGC
CTCATCTACCCCGCCGTCTGCACCAACATCGAGTCCCTCAACAAGGGCTCGGGCTCACTG
TGGACCACCAAGTTTTTCATCCCCCTCACTACCTTCCTCCTGTACAACTTTGCTGACCTA
TGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAATAGCAAGGCGCTCCCA
GGGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTTCGTGCTCTGTAACTACCAGCCC
CGCGTCCACCTGAAGACTGTGGTCTTCCAGTCCGATGTGTACCCCGCACTCCTCAGCTCC
CTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCTCTACGGGCCTAAGATT
GTGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGATGTCCTTTTATGTGTGCTTGGGC
TTAACACTGGGCTCAGCCTGCTCTACCCTCCTGGTGCACCTCATCTAG

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
AF326987

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_4_Locus:
10q22.1

# Macromolecular_Interacting_Partner_4_SNPs:
rs2487068; rs2252996; rs780668; rs2277257; rs999940; rs16928737; rs2252997; rs1084004; rs2275579; rs780680; rs780664; rs1538899; rs780660; rs780659; rs780666; rs703257; rs780654; rs946875; rs703256; rs2394793; rs7069807; rs1110399; rs780677; rs4600131; rs780675; rs2243460; rs780670; rs780676; rs6480510; rs2487067; rs6480511; rs809691; rs883764; rs7086724; rs12256138; rs2012500; rs780662; rs4494244; rs780672; rs780653; rs3781314; rs2249987; rs1538895; rs2066211; rs780655; rs10823723; rs1316421; rs11815656; rs3824770; rs7100381; rs2250002; rs6480513; rs12251921; rs12767108; rs16928705; rs10999773; rs10999778; rs1572810; rs7076329; rs6480514; rs780667; rs7090745; rs2249882; rs883763; rs780679; rs780674; rs7080325; rs3781316; rs2249989; rs780678; rs11812689; rs780669; rs2487066; rs2243496; rs7067629; rs10999776; rs7095417; rs11594628; rs780665; rs4430425; rs4348816; rs780661; rs3781311; rs3781313; rs2249753; rs10999770; rs7091983; rs884031; rs3781324; rs780658; rs10999775; rs7072838; rs780671; rs946973; rs10740374; rs12252326; rs3781310; rs10999771; rs3781309; rs3781312; rs1890885; rs2243540; rs3758570; rs3781317; rs2066209; rs780656; rs7900534; rs7083031; rs2066210; rs6480512; rs12220541; rs884681; rs3781327; rs16928722; rs7068179; rs7090777; rs12249513; rs10740375; rs7913673; rs780673; rs10999777; rs10999781; rs780657; rs7090611; rs884680; rs3781326; rs7086520; rs7071162; rs7071738; rs2249752; rs12252139; rs17525188; rs12252279; rs2243485; rs7071979; rs10999772; rs3781325; rs7087714; rs7084342; rs4747148; rs7924115; rs946979; rs780681; rs1572812; rs35065420; rs6650127; rs34069552; rs10716665; rs35206666; rs12263170; rs10625840; rs34905233; rs11376986; rs35919163; rs5786035; rs34110374; rs12356731; rs35335105; rs12269478; rs12243734; rs34152212; rs7913062; rs3059614; rs12762394; rs7911708; rs7914132; rs4746081; rs7094989; rs35701283; rs12267767; rs12220170; rs7068296; rs34294547; rs35368644; rs41281300; rs3781318; rs4641383; rs7916422; rs34315182; rs10999774; rs35720104; rs10999769; rs35239123; rs7077024; rs3837344; rs7913610; rs10552605; rs10999779; rs780663; rs35509882; rs3893272; rs3059612; rs35156362; rs1609652; rs35485497; rs34058912; rs12243650; rs4147262; rs7903407; rs35942216; rs12763826; rs3837345; rs34297699; rs34965758; rs3824768; rs34491538; rs41300554; rs36074226; rs7095479; rs7067937; rs11296364; rs35855172; rs7897272; rs34640546; rs3781315; rs34395748; rs12355187; rs12261581; rs10686987; rs12779065; rs10999783; rs36087675; rs12762772; rs5786034; rs10999782; rs34650529; rs34632350; rs10553895; rs34721394; rs12249991; rs11593088; rs3059610; rs28708771; rs35956296; rs10999768; rs28688626; rs35685893; rs10823722; rs10999766; rs10999784; rs10999785; rs10999786; rs10999788; rs11595617; rs11816935; rs12098507; rs12254223; rs12412201; rs12414898; rs1538898; rs1609651; rs17546494; rs2185416; rs2248674; rs34217506; rs35016944; rs35685474; rs7079524; rs780682; rs780683; rs780687; rs780688; rs780689; rs780690; rs780692; rs780693; rs780694; rs780695; rs780697; rs780698; rs7895122; rs7899555; rs869545; rs946879

# Macromolecular_Interacting_Partner_4_General_References:
11396612; 12384580; 12975309

# Macromolecular_Interacting_Partner_4_References:
Not Available

End of HMDB00157

Beginning of HMDB00158
# Accession_No:
HMDB00158

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-19 14:47:17

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
L-Tyrosine

# Description:
Tyrosine is an essential amino acid that readily passes the blood-brain barrier. Once in the brain, it is a precursor for the neurotransmitters dopamine, norepinephrine and epinephrine, better known as adrenalin. These neurotransmitters are an important part of the body's sympathetic nervous system, and their concentrations in the body and brain are directly dependent upon dietary tyrosine. Tyrosine is not found in large concentrations throughout the body, probably because it is rapidly metabolized. Folic acid, copper and vitamin C are cofactor nutrients of these reactions. Tyrosine is also the precursor for hormones, thyroid, catecholestrogens and the major human pigment, melanin. Tyrosine is an important amino acid in many proteins, peptides and even enkephalins, the body's natural pain reliever. Valine and other branched amino acids, and possibly tryptophan and phenylalanine may reduce tyrosine absorption. A number of genetic errors of tyrosine metabolism occur. Most common is the increased amount of tyrosine in the blood of premature infants, which is marked by decreased motor activity, lethargy and poor feeding. Infection and intellectual deficits may occur. Vitamin C supplements reverse the disease. Some adults also develop elevated tyrosine in their blood. This indicates a need for more vitamin C. More tyrosine is needed under stress, and tyrosine supplements prevent the stress-induced depletion of norepinephrine and can cure biochemical depression. However, tyrosine may not be good for psychosis. Many antipsychotic medications apparently function by inhibiting tyrosine metabolism. L-dopa, which is directly used in Parkinson's, is made from tyrosine. Tyrosine, the nutrient, can be used as an adjunct in the treatment of Parkinson's. Peripheral metabolism of tyrosine necessitates large doses of tyrosine, however, compared to L-dopa.  (http://www.dcnutrition.com)

# Synonyms:
(-)-a-Amino-p-hydroxyhydrocinnamate; (-)-a-Amino-p-hydroxyhydrocinnamic acid; (-)-alpha-Amino-p-hydroxyhydrocinnamate; (-)-alpha-Amino-p-hydroxyhydrocinnamic acid; (S)-(-)-Tyrosine; (S)-2-Amino-3-(p-hydroxyphenyl)propionate; (S)-2-Amino-3-(p-hydroxyphenyl)propionic acid; (S)-3-(p-Hydroxyphenyl)alanine; (S)-Tyrosine; (S)-a-Amino-4-hydroxybenzenepropanoate; (S)-a-Amino-4-hydroxybenzenepropanoic acid; (S)-a-amino-4-hydroxy-Benzenepropanoate; (S)-a-amino-4-hydroxy-Benzenepropanoic acid; (S)-alpha-amino-4-hydroxy-Benzenepropanoate; (S)-alpha-amino-4-hydroxy-Benzenepropanoic acid; 2-amino-3-(4-hydroxyphen yl)-2-amino-3-(4-hydroxyphenyl)-Propanoate; 2-amino-3-(4-hydroxyphen yl)-2-amino-3-(4-hydroxyphenyl)-Propanoic acid; 3-(4-Hydroxyphenyl)-L-alanine; 4-hydroxy-L-Phenylalanine; Benzenepropanoate; Benzenepropanoic acid; L-p-Tyrosine; L-tyrosine; Tyr; Tyrosine; p-Tyrosine; (S)-alpha-Amino-4-hydroxybenzenepropanoate; (S)-alpha-Amino-4-hydroxybenzenepropanoic acid

# Chemical_IUPAC_Name:
2-amino-3-(4-hydroxyphenyl)-propanoic acid

# Chemical_Formula:
C9H11NO3

# Chemical_Structure:
tbl_chemical:::HMDB00158_ZOOM.png:::119283224560427503

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00158_THUMB.png:::119283224365864073

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids; Nitrogenous Compounds

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
phenol or hydroxyhetarene; primary amine; primary aliphatic amine (alkylamine); carboxylic acid; aromatic compound; alpha-aminoacid

# Taxonomy_Biofunction:
Component of Aminoacyl-tRNA biosynthesis; Component of Novobiocin biosynthesis; Component of Phenylalanine metabolism; Component of Phenylalanine, tyrosine and tryptophan biosynthesis; Component of Riboflavin metabolism; Component of Stilbene, coumarine and lignin biosynthesis; Component of Tyrosine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
181.07388

# Molecular_Weight_Avg:
181.18854

# Smiles_String_isomeric:
N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

# Smiles_String_canonical:
NC(CC1=CC=C(O)C=C1)C(O)=O

# KEGG_Compound_ID:
C00082

# BioCyc_ID:
TYR

# PubChem_CID:
6057

# PubChem_SID:
817487; 8153780; 832231; 585656; 817489; 7854734; 828554; 833120; 834547; 833119; 7847090; 10529154; 8144790; 8028353; 8028352; 823160; 841729; 854649; 7890924; 833118; 829824; 817488; 835612; 585619; 3134840; 148936; 7887220; 817486; 3382; 817482; 8026809; 836242; 739006

# OMIM_ID:
276600; 276700; 300300

# Metagene_ID:
Not Available

# BiGG_ID:
33785

# Wikipedia_ID:
L-Tyrosine

# METLIN_ID:
34

# Ref_ID:
12101068; 15911239; 12297216; 14992292; 9473267; 9849813; 15820760; 822705; 8884658; 12097436; 6696735; 12834252; 6198473

# ChEBI_ID:
17895

# CAS_Registry_Number:
60-18-4

# InChI:
InChI=1/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1

# Synthesis_Reference:
 Agricultural and Biological Chemistry  (1972),  36(11),  1861-8.

# Melting_Point:
343 oC

# Melting_Point_predicted:
111.3 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.479 mg/mL [SEIDELL,A (1941)]

# H2O_Solubility_Predicted:
7.67 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-2.26 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-2.38 [Predicted by ALOGPS]; -1.8 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::L-Tyrosine.pdf:::1132562208140797134

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::L-Tyrosine.mol:::1132723810718741311

# SDF_File_[Text]:
tbl_chemical:::HMDB00158.sdf:::119283224040157004

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00158.pdb:::119283224227171554

# PDB_ID:
1WQ4

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041013_P00_04_HW_1DP_presat.png:::115100517324380654

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041013_P00_04_HW_1DP_presat.zip:::115100517326189988

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041013_P00_04_HW_1DP_Assigned.png:::115680016763711274

# C_NMR_Spectra:
tbl_cnmr:::041013_P00_04_HW_1DC_40.jpg:::114168460157844812

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041013_P00_04_HW_1DC_40.zip:::114168460155249686

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041013_P00_04_HW_1DC_40_Assigned.jpg:::114556219985553668

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041013_P00_04_HW_2DHSQC_3.JPG:::114616896962775353

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041013_P00_04_HW_2DHSQC_3.zip:::114616896989278320

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041013_P00_04_HW_2DHSQC_3_Assigned.jpg:::115887378895378758

# Predicted_H_NMR_Spectrum:
tbl_chemical:::L-Tyrosine.gif:::1132732115265117289

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00158_peaks.txt:::1156309583414622237

# Predicted_C_NMR_Spectrum:
tbl_chemical:::L-Tyrosine_C.gif:::113273770350350009

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00158_peaks.txt:::1156310773163616677

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00158L.png:::117555263465198946; Medium Energy:tbl_ms:::HMDB00158M.png:::117555268762688246; High Energy:tbl_ms:::HMDB00158H.png:::117555271977497653

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000051.png:::116890824679689121

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000051.txt:::116890824679610074

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000051.png:::116890824656295583

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000051.txt:::116890824679622293

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Urine	10.9 (2.566-19.1)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Blood	59.0 (47.0-71.0)	umol/L	Adult:>18_yrs_old	Both	Normal	12297216
Blood	120.0 +/- 100.0	umol/L	Newborn:0-30_days_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	68.0 +/- 10.0	umol/L	Children:1-13_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	72.0 +/- 15.0	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	61.0 +/- 13.0	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	10.1 (6.37-13.8)	umol/L	Adult:>18_yrs_old	Both	Normal	12834252
Cerebrospinal_Fluid(CSF)	38.0 +/- 31.0	uM	Adult:>18_yrs_old	Both	Normal	HMP Experimental
Cerebrospinal_Fluid(CSF)	24.5 +/- 8.9	umol/L	Adult:>18_yrs_old	N/A	Normal	15911239
Cerebrospinal_Fluid(CSF)	6.4 +/- 1.5	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	9.3 +/- 2.0	umol/L	Adult:>18_yrs_old	N/A	Normal	6198473
Cerebrospinal_Fluid(CSF)	7.9 +/- 3.0	umol/L	Adult:>18_yrs_old	N/A	Normal	6198473
Saliva	>10	umol/L	Adult:>18_yrs_old	Both	Normal	12097436


# Concentration_[Abnormal]:
Blood	91.2 +/- 30.0	umol/L	Adult:>18_yrs_old	Both	Schizophrenic patients (Men)	2480613
Blood	73.0 +/- 20.0	umol/L	Adult:>18_yrs_old	Both	Schizophrenic patients (Women)	2480613
Blood	50.7 (46.8-54.6)	umol/L	Adult:>18_yrs_old	Both	Acute seizures	14992292
Blood	60.0	umol/L	Adult:>18_yrs_old	Both	Diabetes	6696735
Blood	74.0 (71.0-77.0)	umol/L	Adult:>18_yrs_old	Both	Myocardial Infarction	822705
Blood	81.0 (75.9-86.1)	umol/L	Adult:>18_yrs_old	Both	Refractory localization-related epilepsy (RLE)	14992292
Blood	90.0 (81.0-99.0)	umol/L	Adult:>18_yrs_old	Both	Viral Infection	822705
Blood	194.0	umol/L	Adult:>18_yrs_old	Both	Neonatal Phenylketonuria	12101068
Blood	210.0	umol/L	Adult:>18_yrs_old	Both	Neonatal Maple syrup urine Disease (MSUD)	12101068
Cerebrospinal_Fluid(CSF)	15.3 (10.4-20.2)	umol/L	Adult:>18_yrs_old	Both	Hypothyroidism	9849813
Cerebrospinal_Fluid(CSF)	14.2 +/-12.5	uM	Adult:>18_yrs_old	N/A	Epilepsy with borderline thiamine	1705463
Cerebrospinal_Fluid(CSF)	13.0 +/- 10.6	uM	Adult:>18_yrs_old	N/A	Epilepsy treated with phenytoin (well controlled)	1705463
Cerebrospinal_Fluid(CSF)	12.3 +/- 9.3 	uM	Adult:>18_yrs_old	N/A	Epilepsy with low folate	1705463
Cerebrospinal_Fluid(CSF)	9.4 +/- 4.9 	uM	Adult:>18_yrs_old	N/A	Epilepsy with low thiamine	1705463
Cerebrospinal_Fluid(CSF)	8.05 +/- 3.03	N/A	Adult:>18_yrs_old	N/A	Epilepsy not treated with phenytoin	1705463
Cerebrospinal_Fluid(CSF)	13.0 +/- 4.1	umol/L	N/A	N/A	Leukemia	15911239
Cerebrospinal_Fluid(CSF)	12.6 +/- 3.3	umol/L	N/A	N/A	Leukemia with CNS disease	15911239
Cerebrospinal_Fluid(CSF)	15.3 +/- 4.9	umol/L	Adult:>18_yrs_old	N/A	hypothyroid patients	9849813
Cerebrospinal_Fluid(CSF)	15.3 +/- 4.9 	uM	Adult:>18_yrs_old	Both	Hypothyroid patients	9849813 


# Associated_Disorders:
2-hydroxyglutaric aciduria; Acute Renal Failure; Acute seizures; Diabetes; End-stage Renal Disease (ESRD); Epilepsy not treated with phenytoin; Epilepsy treated with phenytoin (after Intoxication); Epilepsy treated with phenytoin (Intoxicated); Epilepsy treated with phenytoin (well controlled); Epilepsy with borderline folate; Epilepsy with borderline thiamine; Epilepsy with low folate; Epilepsy with low thiamine; Hereditary Tyrosinemia Type 1; hypothyroid patients; Hypothyroidism; Leukemia; Leukemia with CNS disease; Myocardial Infarction; Neonatal Maple syrup urine Disease (MSUD); Neonatal Phenylketonuria; Refractory localization-related epilepsy (RLE); Richner Hanhart Syndrome; Schizophrenic patients (Men); Schizophrenic patients (Women); Viral Infection

# Pathway_Names:
Alanine and aspartate metabolism

# Pathway_Images:
Aspartate_and_Alanine_metabolism.jpg

# KEGG_Images:
map00252

# Pathway_Graphs:
Aspartate_and_Alanine_metabolism_Graph.jpg

# Pathway_SBMLs:
Aspartate_and_Alanine_metabolism.xml

# Metabolic_Enzyme_1_ID:
5505

# Metabolic_Enzyme_1_Name:
Tyrosine 3-monooxygenase

# Metabolic_Enzyme_1_Synonyms:
Tyrosine 3-hydroxylase; TH

# Metabolic_Enzyme_1_Gene_Name:
TH

# Metabolic_Enzyme_1_Protein_Sequence:
>Tyrosine 3monooxygenase
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTP
RSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPR
ATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVR
QVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEI
AFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNI
PQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCC
HELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQNGEVKAYG
AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYAS
RIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG

# Metabolic_Enzyme_1_Number_of_Residues:
528

# Metabolic_Enzyme_1_Molecular_Weight:
58525

# Metabolic_Enzyme_1_Theoretical_pI:
6.25

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  tyrosine 3-monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  catecholamine metabolism
Process:  catecholamine biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Plays an important role in the physiology of adrenergic neurons

# Metabolic_Enzyme_1_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_1_Reaction:
L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00351:Biopterin_H

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.14.16.2

# Metabolic_Enzyme_1_GenBank_ID_Protein:
37127

# Metabolic_Enzyme_1_SwissProt_ID:
TY3H_HUMAN (P07101)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
TH

# Metabolic_Enzyme_1_Geneatlas_id:
TH

# Metabolic_Enzyme_1_hgnc_id:
HGNC:11782

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1575 bp
ATGCCCACCCCCGACGCCACCACGCCACAGGCCAAGGGCTTCCGCAGGGCCGTGTCTGAG
CTGGACGCCAAGCAGGCAGAGGCCATCATGGGCGCCCCGGGGCCCAGCCTCACAGGCTCT
CCGTGGCCTGGAACTGCAGCCCCAGCTGCATCCTACACCCCCACCCCAAGGTCCCCGCGG
TTCATTGGGCGCAGGCAGAGCCTCATCGAGGACGCCCGCAAGGAGCGGGAGGCGGCGGTG
GCAGCAGCGGCCGCTGCAGTCCCCTCGGAGCCCGGGGACCCCCTGGAGGCTGTGGCCTTT
GAGGAGAAGGAGGGGAAGGCCGTGCTAAACCTGCTCTTCTCCCCGAGGGCCACCAAGCCC
TCGGCGCTGTCCCGAGCTGTGAAGGTGTTTGAGACGTTTGAAGCCAAAATCCACCATCTA
GAGACCCGGCCCGCCCAGAGGCCGCGAGCTGGGGGCCCCCACCTGGAGTACTTCGTGCGC
CTCGAGGTGCGCCGAGGGGACCTGGCCGCCCTGCTCAGTGGTGTGCGCCAGGTGTCAGAG
GACGTGCGCAGCCCCGCGGGGCCCAAGGTCCCCTGGTTCCCAAGAAAAGTGTCAGAGCTG
GACAAGTGTCATCACCTGGTCACCAAGTTCGACCCTGACCTGGACTTGGACCACCCGGGC
TTCTCGGACCAGGTGTACCGCCAGCGCAGGAAGCTGATTGCTGAGATCGCCTTCCAGTAC
AGGCACGGCGACCCGATTCCCCGTGTGGAGTACACCGCCGAGGAGATTGCCACCTGGAAG
GAGGTCTACACCACGCTGAAGGGCCTCTACGCCACGCACGCCTGCGGGGAGCACCTGGAG
GCCTTTGCTTTGCTGGAGCGCTTCAGCGGCTACCGGGAAGACAATATCCCCCAGCTGGAG
GACGTCTCCCGCTTCCTGAAGGAGCGCACGGGCTTCCAGCTGCGGCCTGTGGCCGGCCTG
CTGTCCGCCCGGGACTTCCTGGCCAGCCTGGCCTTCCGCGTGTTCCAGTGCACCCAGTAT
ATCCGCCACGCGTCCTCGCCCATGCACTCCCCTGAGCCGGACTGCTGCCACGAGCTGCTG
GGGCACGTGCCCATGCTGGCCGACCGCACCTTCGCGCAGTTCTCGCAGGACATTGGCCTG
GCGTCCCTGGGGGCCTCGGATGAGGAAATTGAGAAGCTGTCCACGCTGTCATGGTTCACG
GTGGAGTTCGGGCTGTGTAAGCAGAACGGGGAGGTGAAGGCCTATGGTGCCGGGCTGCTG
TCCTCCTACGGGGAGCTCCTGCACTGCCTGTCTGAGGAGCCTGAGATTCGGGCCTTCGAC
CCTGAGGCTGCGGCCGTGCAGCCCTACCAAGACCAGACGTACCAGTCAGTCTACTTCGTG
TCTGAGAGCTTCAGTGACGCCAAGGACAAGCTCAGGAGCTATGCCTCACGCATCCAGCGC
CCCTTCTCCGTGAAGTTCGACCCGTACACGCTGGCCATCGACGTGCTGGACAGCCCCCAG
GCCGTGCGGCGCTCCCTGGAGGGTGTCCAGGATGAGCTGGACACCCTTGCCCATGCGCTG
AGTGCCATTGGCTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
Y00414

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_1_Locus:
11p15.5

# Metabolic_Enzyme_1_SNPs:
rs6356; rs7950050; rs6357; rs34510659; rs11826260; rs3842725; rs10840489; rs11825601; rs4074905; rs12419447; rs2070762; rs7482510; rs3842722; rs7925924; rs7942881; rs11826130; rs7483805; rs7483056; rs4072826; rs4072824; rs7925375; rs7479936; rs4072823; rs3842723; rs10743149; rs10770140; rs3842727; rs7119275; rs7115640; rs10840490; rs10770141; rs11564711; rs10840491; rs3842726; rs11042962; rs10770142; rs28934581; rs28934579; rs28934580; rs1800033; rs36097848; rs3842724; rs1799833; rs11564716; rs34723540; rs6578990; rs11042950; rs3842721; rs35596265; rs11564713; rs11564712; rs36009557; rs4930043; rs36010304; rs7925784; rs35996457; rs4072825; rs35125951; rs11564714; rs35444567; rs34965351; rs11564715; rs11564717; rs10734659; rs11564718; rs1800032; rs10743152; rs10770143; rs10840447; rs10840452; rs10840495; rs10840496; rs10840502; rs11042965; rs11042966; rs11042971; rs11042976; rs11042978; rs11042982; rs11042984; rs11042987; rs11564709; rs11564710; rs11564720; rs2000993; rs28494588; rs28933985; rs3842733; rs3842738; rs3842741; rs3842748; rs3842752; rs3842753; rs3842754; rs3842756; rs3842768; rs3842769; rs3842770; rs3842775; rs4929964; rs4929966; rs4930046; rs5505; rs5506; rs5507; rs6578993; rs689; rs7110099; rs7128097; rs7482891; rs7936868

# Metabolic_Enzyme_1_General_References:
2882428; 2888085; 2887169; 2902075; 2892893; 2896667; 7814018; 7789962; 8528210; 8817341; 9613851; 9754624; 9703425; 10391209; 11246459

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5891

# Metabolic_Enzyme_2_Name:
Tyrosyl-tRNA synthetase, mitochondrial precursor

# Metabolic_Enzyme_2_Synonyms:
Tyrosine--tRNA ligase; TyrRS

# Metabolic_Enzyme_2_Gene_Name:
YARS2

# Metabolic_Enzyme_2_Protein_Sequence:
>TyrosyltRNA synthetase, mitochondrial precursor
MAAPILRSFSWGRWSGTLNLSVLLPLGLRKAHSGAQGLLAAQKARGLFKDFFPETGTKIE
LPELFDRGTASFPQTIYCGFDPTADSLHVGHLLALLGLFHLQRAGHNVIALVGGATARLG
DPSGRTKEREALETERVRANARALRLGLEALAANHQQLFTDGRSWGSFTVLDNSAWYQKQ
HLVDFLAAVGGHFRMGTLLSRQSVQLRLKSPEGMSLAEFFYQVLQAYDFYYLFQRYGCRV
QLGGSDQLGNIMSGYEFINKLTGEDVFGITVPLITSTTGAKLGKSAGNAVWLNRDKTSPF
ELYQFFVRQPDDSVERYLKLFTFLPLPEIDHIMQLHVKEPERRGPQKRLAAEVTKLVHGR
EGLDSAKRCTQALYHSSIDALEVMSDQELKELFKEAPFSEFFLDPGTSVLDTCRKANAIP
DGPRGYRMITEGGVSINHQQVTNPESVLIVGQHILKNGLSLLKIGKRNFYIIKWLQL

# Metabolic_Enzyme_2_Number_of_Residues:
477

# Metabolic_Enzyme_2_Molecular_Weight:
53200

# Metabolic_Enzyme_2_Theoretical_pI:
9.34

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  tyrosine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  tyrosyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_2_Specific_Function:
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)

# Metabolic_Enzyme_2_Pathway:
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_2_Reaction:
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00579:tRNA-synt_1b

# Metabolic_Enzyme_2_Signals:
1-33

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 6.1.1.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
4680649

# Metabolic_Enzyme_2_SwissProt_ID:
SYYM_HUMAN (Q9Y2Z4)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
YARS2

# Metabolic_Enzyme_2_Geneatlas_id:
YARS2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:24249

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_2_Gene_Sequence:
>1431 bp
ATGGGCGCCATCTTGCGGTCCTTTTCCTGGGGCCGGTGGTCTGGTACCCTAAATCTCTCA
GTATTGTTGCCCTTGGGGCTGCGTAAGGCCCACTCGGGCGCTCAGGGGTTACTGGCAGCG
CAGAAGGCTCGAGGTCTGTTCAAGGACTTCTTCCCGGAGACGGGGACGAAAATAGAGCTC
CCAGAGCTCTTCGACCGTGGCACGGCGAGTTTTCCCCAAACCATTTACTGTGGCTTCGAC
CCCACGGCAGACTCGCTTCATGTGGGTCATCTACTTGCGCTGCTGGGTCTGTTTCATTTG
CAGCGAGCGGGCCACAACGTGATCGCGCTGGTGGGAGGCGCCACGGCGGCCCTGGGAGAC
CCGAGCGGCCGTACCAAGGAACGCGAGGCGCTGGAGACAGAGCGCGTGCGAGCCAACGCG
CGAGCTCTGCGCCTAGGGCTTGAGGCCCTGGCGGCTAATCACCAGCAGCTTTTCACTGAT
GGGCGCTCCTGGGGCAGCTTCACTGTGCTGGACAACTCGGCCTGGTACCAGAAGCAGCAC
CTGGTGGACTTCCTGGCGGCAGTGGGGGTTCACTTCCGCATGGGGACGCTGCTGAGCCGG
CAGAGCGTGCAGCTGCGGCTCAAGAGCCCCGAGGGCATGAGCTTGGCCGAGTTCTTTTAC
CAGGTGCTCCAGGCCTATGACTTCTATTACCTCTTCCAGCGTTATGGATGCAGGGTCCAG
CTGGGCGGATCTGATCAACTAGGCAACATCATGTCCGGATATGAGTTCATCAACAAGTTG
ACTGGAGAAGATGTATTTGGAATCACCGTTACTCTAATTACAAGTACAACTGGAGCAAAG
CTGGGAAAGTCTGCTGGCAACGCTGTTTGGCTAAACAGAGATAAGACATCTCCATTTGAA
TTGTATCAATTCTTTGTCAGACAACCCGAGGATTCAGTGGAAAGGTACCTGAAGCTGTTC
ACTTTCCTGCCCCTCCCAGAGATTGATCATATCATGCAGCTGCATGTCAAAGAGCCAGAA
AGGCGGGGTCCTCAGAAACGACTGGCAGCAGAAGTAACAAAGCTTGTTCATGGACGAGAA
GGATTGGATTCTGCTAAAAGGTGTACACAAGCCCTTTATCACAGTAGCATAGATGCACTG
GAGGTCATGTCTGATCAGGAGTTAAAAGAGTTGTTTAAAGAAGCTCCATTTTCTGAATTT
TTTCTCGATCCTGGAACAAGTGTCCTAGATACTTGCCGCAAAGCAAATGCCATTCCAGAT
GGTCCCCGAGGGTATCGAATGATAACAGAAGGCGGAGTCAGCATAAATCACCAACAAGTA
ACAAATCCTGAGAGTGTTTTAATTGTTGGACAACATATTCTCAAGAATGGACTTTCCTTA
CTTAAAATAGGAAAAAGAAATTTCTACATTATAAAATGGCTTCAGTTGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF132939

# Metabolic_Enzyme_2_Chromosome_Location:
Not Available

# Metabolic_Enzyme_2_Locus:
Not Available

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
10810093

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5878

# Metabolic_Enzyme_3_Name:
Tyrosyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_3_Synonyms:
Tyrosyl--tRNA ligase; TyrRS

# Metabolic_Enzyme_3_Gene_Name:
YARS

# Metabolic_Enzyme_3_Protein_Sequence:
>TyrosyltRNA synthetase, cytoplasmic
MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIA
DFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKG
TDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVD
AQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKED
VKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFA
AEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEP
EEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLV
VVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEE
LKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS

# Metabolic_Enzyme_3_Number_of_Residues:
528

# Metabolic_Enzyme_3_Molecular_Weight:
59144

# Metabolic_Enzyme_3_Theoretical_pI:
7.05

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  tyrosine-tRNA ligase activity
Function:  nucleic acid binding
Function:  RNA binding
Function:  tRNA binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  tyrosyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_3_Specific_Function:
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)

# Metabolic_Enzyme_3_Pathway:
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_3_Reaction:
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00579:tRNA-synt_1b;
PF01588:tRNA_bind

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 6.1.1.1

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1184699

# Metabolic_Enzyme_3_SwissProt_ID:
SYYC_HUMAN (P54577)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
YARS

# Metabolic_Enzyme_3_Geneatlas_id:
YARS

# Metabolic_Enzyme_3_hgnc_id:
HGNC:12840

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>1167 bp
ATGGGGGACGCTCCCAGCCCTGAAGAGAAACTGCACCTTATCACCCGGAACCTGCAGGAG
GTTCTGGGGGAAGAGAAGCTGAAGGAGATACTGAAGGAGCGGGAACTTAAAATTTACTGG
GGAACGGCAACCACGGGCAAACCACATGTGGCTTACTTTGTGCCCATGTCAAAGATTGCA
GACTTCTTAAAGGCAGGGTGTGAGGTAACAATTCTGTTTGCGGACCTCCACGCATACCTG
GATAACATGAAAGCCCCATGGGAACTTCTAGAACTCCGAGTCAGTTACTATGAGAATGTG
ATCAAAGCAATGCTGGAGAGCATTGGTGTGCCCTTGGAGAAGCTCAAGTTCATCAAAGGC
ACTGATTACCAGCTCAGCAAAGAGTACACACTAGATGTGTACAGACTCTCCTCCGTGGTC
ACACAGCACGATTCCAAGAAGGCTGGAGCTGAGGTGGTAAAGCAGGTGGAGCACCCTTTG
CTGAGTGGCCTCTTATACCCCGGACTGCAGGCTTTGGATGAAGAGTATTTAAAAGTAGAT
GCCCAATTTGGAGGCATTGATCAGAGAAAGATTTTCACCTTTGCAGAGAAGTACCTCCCT
GCACTTGGCTATTCAAAACGGGTCCATCTGATGAATCCTATGGTTCCAGGATTAACAGGC
AGCAAAATGAGCTCTTCAGAAGAGGAGTCCAAGATTGATCTCCTTGATCGGAAGGAGGAT
GTGAAGAAAAAACTGAAGAAGGCCTTCTGTGAGCCAGGAAATGTGGAGAACAATGGGGTT
CTGTCCTTCATCAAGCATGTCCTTTTTCCCCTTAAGTCCGAGTTTGTGATCCTACGAGAT
GAGAAATGGGGTGGAAACAAAACCTACACAGCTTACGTGGACCTGGAAAAGGACTTTGCT
GCTGAGGTTGTACATCCTGGAGACCTGAAGAATTCTGTTGAAGTCGCACTGAACAAGTTG
CTGGATCCAATCCGGGAAAAGTTTAATACCCCTGCCCTGAAAAAACTGGCCAGCGCTGCC
TACCCAGATCCCTCAAAGCAGAAGCCAATGGCCAAAGGCCTGCCAAGAATTCAGAACCAG
AGGAGGTCATCCCATCCCGGCTGGATATCCGTGTGGGGAAAATCATCACTGTGGAGAAGC
ACCCAGATGCAGACAGCCTGTATGTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U40714

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
8552597; 9162081; 12665801

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5508

# Metabolic_Enzyme_4_Name:
Thyroid peroxidase precursor

# Metabolic_Enzyme_4_Synonyms:
TPO

# Metabolic_Enzyme_4_Gene_Name:
TPO

# Metabolic_Enzyme_4_Protein_Sequence:
>Thyroid peroxidase precursor
MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR
NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS
EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV
YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD
IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD
QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG
RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA
LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT
VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIR
GLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGL
PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ
MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES
CDSIPGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL
TCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD
SGRLPRATWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ
AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL

# Metabolic_Enzyme_4_Number_of_Residues:
933

# Metabolic_Enzyme_4_Molecular_Weight:
102932

# Metabolic_Enzyme_4_Theoretical_pI:
6.75

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4)

# Metabolic_Enzyme_4_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_4_Reaction:
iodide + H2O2 = iodine + 2 H2O

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF03098:An_peroxidase;
PF07645:EGF_CA;
PF00084:Sushi

# Metabolic_Enzyme_4_Signals:
1-14

# Metabolic_Enzyme_4_Transmembrane_Regions:
847-871

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.11.1.8

# Metabolic_Enzyme_4_GenBank_ID_Protein:
339867

# Metabolic_Enzyme_4_SwissProt_ID:
PERT_HUMAN (P07202)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
TPO

# Metabolic_Enzyme_4_Geneatlas_id:
TPO

# Metabolic_Enzyme_4_hgnc_id:
HGNC:12015

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Metabolic_Enzyme_4_Gene_Sequence:
>2802 bp
ATGAGAGCGCTCGCTGTGCTGTCTGTCACGCTGGTTATGGCCTGCACAGAAGCCTTCTTC
CCCTTCATCTCGAGAGGGAAAGAACTCCTTTGGGGAAAGCCTGAGGAGTCTCGTGTCTCT
AGCGTCTTGGAGGAAAGCAAGCGCCTGGTGGACACCGCCATGTACGCCACGATGCAGAGA
AACCTCAAGAAAAGAGGAATCCTTTCTCCAGCTCAGCTTCTGTCTTTTTCCAAACTTCCT
GAGCCAACAAGCGGAGTGATTGCCCGAGCAGCAGAGATAATGGAAACATCAATACAAGCG
ATGAAAAGAAAAGTCAACCTGAAAACTCAACAATCACAGCATCCAACGGATGCTTTATCA
GAAGATCTGCTGAGCATCATTGCAAACATGTCTGGATGTCTCCCTTACATGCTGCCCCCA
AAATGCCCAAACACTTGCCTGGCGAACAAATACAGGCCCATCACAGGAGCTTGCAACAAC
AGAGACCACCCCAGATGGGGCGCCTCCAACACGGCCCTGGCACGATGGCTCCCTCCAGTC
TATGAGGACGGCTTCAGTCAGCCCCGAGGCTGGAACCCCGGCTTCTTGTACAACGGGTTC
CCACTGCCCCCGGTCCGGGAGGTGACAAGACATGTCATTCAAGTTTCAAATGAGGTTGTC
ACAGATGATGACCGCTATTCTGACCTCCTGATGGCATGGGGACAATACATCGACCACGAC
ATCGCGTTCACACCACAGAGCACCAGCAAAGCTGCCTTCGGGGGAGGGGCTGACTGCCAG
ATGACTTGTGAGAACCAAAACCCATGTTTTCCCATACAACTCCCGGAGGAGGCCCGGCCG
GCCGCGGGCACCGCCTGTCTGCCCTTCTACCGCTCTTCGGCCGCCTGCGGCACCGGGGAC
CAAGGCGCGCTCTTTGGGAACCTGTCCACGGCCAACCCGCGGCAGCAGATGAACGGGTTG
ACCTCGTTCCTGGACGCGTCCACCGTGTATGGCAGCTCCCCGGCCCTAGAGAGGCAGCTG
CGGAACTGGACCAGTGCCGAAGGGCTGCTCCGCGTCCACGCGCGCCTCCGGGACTCCGGC
CGCGCCTACCTGCCCTTCGTGCCGCCACGGCGGCCTGCGGCCTGTGCGCCCGAGCCCGGC
ATCCCCGGAGAGACCCGCGGGCCCTGCTTCCTGGCCGGAGACGGCCGCGCCAGCGAGGTC
CCCTCCCTGACGGCACTGCACACGCTGTGGCTGCGCGAGCACAACCGCCTGGCCGCGGCG
CTCAAGGCCCTCAATGCGCACTGGAGCGCGGACGCCGTGTACCAGGAGGCGCGCAAGGTC
GTGGGCGCTCTGCACCAGATCATCACCCTGAGGGATTACATCCCCAGGATCCTGGGACCC
GAGGCCTTCCAGCAGTACGTGGGTCCCTATGAAGGCTATGACTCCACCGCCAACCCCACT
GTGTCCAACGTGTTCTCCACAGCCGCCTTCCGCTTCGGCCATGCCACGATCCACCCGCTG
GTGAGGAGGCTGGACGCCAGCTTCCAGGAGCACCCCGACCTGCCCGGGCTGTGGCTGCAC
CAGGCTTTCTTCAGCCCATGGACATTACTCCGTGGAGGTGGTTTGGACCCACTAATACGA
GGCCTTCTTGCAAGACCAGCCAAACTGCAGGTGCAGGATCAGCTGATGAACGAGGAGCTG
ACGGAAAGGCTCTTTGTGCTGTCCAATTCCAGCACCTTGGATCTGGCGTCCATCAACCTG
CAGAGGGGCCGGGACCACGGGCTGCCAGGTTACAATGAGTGGAGGGAGTTCTGCGGCCTG
CCTCGCCTGGAGACCCCCGCTGACCTGAGCACAGCCATCGCCAGCAGGAGCGTGGCCGAC
AAGATCCTGGACTTGTACAAGCATCCTGACAACATCGATGTCTGGCTGGGAGGCTTAGCT
GAAAACTTCCTCCCCAGGGCTCGGACAGGGCCCCTGTTTGCCTGTCTCATTGGGAAGCAG
ATGAAGGCTCTGCGGGATGGTGACTGGTTTTGGTGGGAGAACAGCCACGTCTTCACGGAT
GCACAGAGGCGTGAGCTGGAGAAGCACTCCCTGTCTCGGGTCATCTGTGACAACACTGGC
CTCACCAGGGTGCCCATGGATGCCTTCCAAGTCGGCAAATTCCCTGAAGACTTTGAGTCT
TGTGACAGCATCCCTGGCATGAACCTGGAGGCCTGGAGGGAAACCTTTCCTCAAGACGAC
AAGTGTGGCTTCCCAGAGAGCGTGGAGAATGGGGACTTTGTGCACTGTGAGGAGTCTGGG
AGGCGCGTGCTGGTGTATTCCTGCCGGCACGGGTATGAGCTCCAAGGCCGGGAGCAGCTC
ACTTGCACCCAGGAAGGATGGGATTTCCAGCCTCCCCTCTGCAAAGATGTGAACGAGTGT
GCAGACGGTGCCCACCCCCCCTGCCACGCCTCTGCGAGGTGCAGAAACACCAAAGGCGGC
TTCCAGTGTCTCTGCGCGGACCCCTACGAGTTAGGAGACGATGGGAGAACCTGCGTAGAC
TCCGGGAGGCTCCCTCGGGCGACTTGGATCTCCATGTCGCTGGCTGCTCTGCTGATCGGA
GGCTTCGCAGGTCTCACCTCGACGGTGATTTGCAGGTGGACACGCACTGGCACTAAATCC
ACACTGCCCATCTCGGAGACAGGCGGAGGAACTCCCGAGCTGAGATGCGGAAAGCACCAG
GCCGTAGGGACCTCACCGCAGCGGGCCGCAGCTCAGGACTCGGAGCAGGAGAGTGCTGGG
ATGGAAGGCCGGGATACTCACAGGCTGCCGAGAGCCCTCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
J02969

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_4_Locus:
2p25

# Metabolic_Enzyme_4_SNPs:
rs2175977; rs13431173; rs732609; rs4927611; rs1126799; rs10189135; rs1042589; rs2280132; rs28915688; rs28991293; rs28913014; rs732608; rs13429240; rs17091745; rs28915689; rs28909989; rs28910597; rs9678281; rs17415659; rs2071403; rs9326166; rs9326167; rs17091628; rs28909986; rs28909987; rs2009364; rs1464083; rs1514686; rs1464086; rs2048726; rs2048722; rs961028; rs1965406; rs2048721; rs1514682; rs1877854; rs6715129; rs7602540; rs949835; rs938330; rs9679017; rs6706775; rs9751670; rs10198697; rs1399390; rs11211650; rs2070878; rs13424221; rs1399387; rs10172186; rs10206727; rs11694817; rs3755554; rs6588672; rs10165715; rs10208730; rs9326170; rs4927624; rs4927612; rs2070879; rs4278970; rs4927619; rs13430369; rs13413321; rs2276702; rs6716111; rs2175978; rs10204647; rs1877855; rs7583792; rs6717381; rs4927615; rs2280129; rs7598233; rs6711545; rs11891272; rs13425669; rs11886972; rs7596885; rs6716250; rs11211651; rs6732480; rs9679267; rs6747390; rs6588665; rs867983; rs9326169; rs11896517; rs1464085; rs11888851; rs6708496; rs7602332; rs10170919; rs2361754; rs1464084; rs6714887; rs6759960; rs1514688; rs2090154; rs1913584; rs6708273; rs10204515; rs3755555; rs11888196; rs10201842; rs6711901; rs938327; rs2138018; rs1567918; rs6760043; rs10171105; rs2138019; rs4927610; rs6752121; rs10205811; rs11211654; rs6740728; rs10189329; rs6727192; rs2070881; rs1965405; rs6588664; rs1473936; rs10177597; rs11897437; rs1967512; rs2885361; rs2361748; rs4927631; rs1514687; rs11690515; rs11904276; rs950675; rs6588669; rs10169429; rs4927621; rs11896057; rs6588674; rs11691841; rs6588673; rs10197874; rs9678469; rs9751407; rs4927608; rs2014911; rs6723319; rs1399389; rs4927580; rs10205420; rs11897713; rs2885362; rs11211653; rs2070882; rs9750182; rs6588663; rs12615819; rs4927578; rs10174000; rs13386909; rs6754104; rs17732233; rs6718027; rs11891867; rs13393765; rs11211649; rs10193983; rs13398180; rs4927574; rs11687944; rs9973690; rs2280131; rs7574221; rs12465127; rs11675388; rs10200413; rs10167570; rs13412229; rs6588676; rs13429459; rs3755549; rs12328748; rs13427125; rs28361468; rs9326171; rs3834179; rs3755548; rs4359704; rs2361767; rs10188260; rs11694726; rs17091772; rs10165832; rs949834; rs11674560; rs4927581; rs7424680; rs3796122; rs13412980; rs17731349; rs9677050; rs4927606; rs13431646; rs13415674; rs949833; rs4927593; rs4927585; rs4600709; rs1514685; rs4328675; rs4927591; rs17731324; rs4425120; rs11899801; rs10495482; rs4927589; rs2070877; rs4927632; rs2070880; rs2048727; rs2276701; rs12619427; rs13431898; rs3755550; rs10519477; rs12472829; rs6588671; rs10170270; rs13405352; rs1976692; rs10189437; rs3772076; rs3772075; rs6588667; rs11683914; rs11211647; rs4481033; rs13431282; rs2276704; rs11691963; rs11891228; rs10166929; rs2280128; rs10190245; rs6588675; rs4927590; rs13414566; rs2361750; rs10196514; rs1514684; rs4592894; rs3772074; rs4927579; rs28663288; rs6588670; rs11211652; rs7355479; rs11692536; rs13409391; rs12470856; rs3755551; rs10181072; rs11691145; rs13405477; rs17091682; rs11682961; rs6712430; rs11897718; rs10194040; rs10207656; rs11681087; rs11211646; rs17091633; rs13400150; rs4927575; rs949832; rs1969248; rs17091667; rs13418264; rs7564759; rs1818525; rs13392535; rs11689536; rs11896906; rs17091737; rs3755553; rs3755552; rs12478431; rs4927617; rs6751783; rs9326172; rs1514683; rs11887707; rs938328; rs6588678; rs17091744; rs2048724; rs11211655; rs2007268; rs28913037; rs28909998; rs13409815; rs10890518; rs28910600; rs28912368; rs11886764; rs28913007; rs28910585; rs28912975; rs28910579; rs7607582; rs28912989; rs9326168; rs28911496; rs28991288; rs28913033; rs28910603; rs28910595; rs28915678; rs28909396; rs28909371; rs9798488; rs28912994; rs11904640; rs12616671; rs28911471; rs28909384; rs28913016; rs28991294; rs28912972; rs13016763; rs12471358; rs28991276; rs28909999; rs13422969; rs11675177; rs28911488; rs28909393; rs28915676; rs28912991; rs4927607; rs28910607; rs6588668; rs4927614; rs12471599; rs11685779; rs28910000; rs28913029; rs28909401; rs28910568; rs28991269; rs28912974; rs11686432; rs11674407; rs28910591; rs28991283; rs4927586; rs28913003; rs2361744; rs2138020; rs4927592; rs28991290; rs28915672; rs28909379; rs28909400; rs29001651; rs28911495; rs28911485; rs28909994; rs28909372; rs28911492; rs4927594; rs28910575; rs10181280; rs28911481; rs11695695; rs28910578; rs28913271; rs28909415; rs4927622; rs28909397; rs28913022; rs11678545; rs28909390; rs28911170; rs28910007; rs11899018; rs28915677; rs28910594; rs28911470; rs9677934; rs12328533; rs28915670; rs28991273; rs17732056; rs28911475; rs28913008; rs9677308; rs28910586; rs28910606; rs28909380; rs28912992; rs28909402; rs28910574; rs9678767; rs6711500; rs28911487; rs28913023; rs28915684; rs4927577; rs13391992; rs28909411; rs11211648; rs11685540; rs28913275; rs28912969; rs28913030; rs28915673; rs28991277; rs28909407; rs28909387; rs28909993; rs28911480; rs4567992; rs28911171; rs13394978; rs28911493; rs28913041; rs11885587; rs28910583; rs28913270; rs28912999; rs2138017; rs10197546; rs28991289; rs4927628; rs9678341; rs28913004; rs28911478; rs28910013; rs28912996; rs10205550; rs28910599; rs13391557; rs28909391; rs28915680; rs4927582; rs4927625; rs17731501; rs13409953; rs11676827; rs13418570; rs11683140; rs9677680; rs13394194; rs28913013; rs28912985; rs11889947; rs28912981; rs1113829; rs4927584; rs10207591; rs28912980; rs2048725; rs28913274; rs4927613; rs28991274; rs28913011; rs28910005; rs28910002; rs9678972; rs13016765; rs17091706; rs28909403; rs28991281; rs28910605; rs28909383; rs28913273; rs28913017; rs28913024; rs13410529; rs7591179; rs28910611; rs28909394; rs28915685; rs28910580; rs11899974; rs12468041; rs11690402; rs28909368; rs28915674; rs28909373; rs28912998; rs28913009; rs28913039; rs28911175; rs28913035; rs17091666; rs28911490; rs28991270; rs28910577; rs28909992; rs28910001; rs28911172; rs28912984; rs4927588; rs28910571; rs28910010; rs4425119; rs28909389; rs28913028; rs13399844; rs4314036; rs12621034; rs4927609; rs28915668; rs4645041; rs13426289; rs4927616; rs28910609; rs28912988; rs28913040; rs11687912; rs28991285; rs28910573; rs28910584; rs28913020; rs28911476; rs28910602; rs28913005; rs6588666; rs11676091; rs28913031; rs10204402; rs28913001; rs28909668; rs28911483; rs28911473; rs28909374; rs28911468; rs13430623; rs28909386; rs28991271; rs28909382; rs28913021; rs12328004; rs28910576; rs11695385; rs1965407; rs28910601; rs28909990; rs4629198; rs28912993; rs10193135; rs28913010; rs28911173; rs28912977; rs7568087; rs28910014; rs1828865; rs12718450; rs28911491; rs11674711; rs28911168; rs4927587; rs28909991; rs28910581; rs28910610; rs28909395; rs4927583; rs28913018; rs1567919; rs28912971; rs28913036; rs28991275; rs28913042; rs28915675; rs28991287; rs28910588; rs28991278; rs961029; rs28912990; rs28913019; rs1567917; rs28910608; rs28909408; rs28912987; rs28909375; rs28915669; rs28912970; rs28909385; rs7597945; rs28991272; rs28913269; rs11676046; rs28909392; rs28909414; rs28909388; rs28910011; rs28912983; rs12105374; rs28991279; rs4404322; rs28915671; rs28911482; rs12613496; rs13431561; rs4927630; rs28913272; rs28912973; rs28911469; rs28911472; rs28909399; rs28913006; rs28911494; rs28910572; rs11690812; rs13415386; rs2071399; rs2280126; rs2298876; rs2071402; rs2071401; rs4927604; rs2280127; rs2071400; rs28991568; rs28915690; rs28909983; rs2298875; rs28910612; rs28991292; rs17855780; rs28915687; rs28910598; rs3732349; rs35105246; rs13407655; rs28909988; rs28915683; rs10536458; rs35505969; rs12474694; rs6755275; rs10180652; rs12993998; rs33961599; rs28909381; rs28360867; rs4927627; rs11681539; rs13410524; rs13383329; rs28912968; rs13415459; rs9973956; rs35756267; rs28909376; rs35523187; rs2048723; rs28630635; rs13031189; rs28911174; rs28633865; rs28909410; rs10629723; rs28909378; rs11677995; rs34132009; rs13413324; rs28911474; rs28910590; rs12994019; rs34920078; rs13000154; rs13000160; rs35605249; rs10166153; rs35043612; rs10666298; rs13026152; rs2885358; rs33990262; rs28910604; rs28910582; rs11688703; rs34374057; rs28912978; rs10176490; rs28915686; rs34413546; rs28632119; rs35225495; rs13430142; rs35431867; rs12987712; rs28460424; rs35944967; rs10184056; rs35732856; rs35531860; rs36119335; rs13396955; rs28909406; rs13020227; rs10203030; rs12612745; rs11689344; rs28912982; rs10206512; rs28912986; rs7369446; rs11686894; rs28909997; rs12986996; rs11691839; rs13035669; rs28580848; rs13006856; rs13385085; rs13415301; rs3831487; rs10190227; rs11686114; rs28912995; rs12616672; rs11412726; rs28915679; rs35725026; rs28672357; rs35893094; rs28910012; rs12476324; rs10608158; rs28874626; rs28909369; rs28464331; rs28445930; rs12986956; rs28913038; rs28991280; rs34191654; rs28665837; rs12478638; rs1399391; rs11688366; rs13006647; rs28910003; rs13036149; rs6705010; rs28671559; rs35708755; rs2280130; rs13410383; rs13393048; rs28909412; rs13430024; rs28912979; rs13382606; rs10193732; rs10573336; rs34043302; rs9677153; rs35874586; rs13382789; rs28437604; rs11678127; rs13430374; rs36220342; rs13397445; rs35553172; rs34128932; rs28911484; rs28991284; rs13431558; rs11687959; rs12105080; rs28991268; rs13027675; rs13000139; rs28651176; rs11687787; rs35908928; rs10208039; rs28913000; rs28729219; rs28566655; rs10194736; rs13026377; rs10666299; rs13420584; rs28910006; rs9677433; rs13424741; rs10184419; rs34359520; rs35103896; rs34099200; rs28909996; rs28433376; rs11904785; rs5828821; rs28909377; rs12612565; rs11272722; rs13392954; rs35752553; rs35208164; rs28378083; rs34080455; rs28913012; rs28636451; rs11272011; rs12992674; rs11412725; rs28435455; rs35700910; rs35500489; rs35104320; rs35727441; rs34796953; rs7369268; rs7368786; rs28591627; rs28420122; rs35584537; rs11691743; rs35123035; rs34032155; rs28910008; rs4927605; rs2885360; rs3036100; rs28910587; rs34933514; rs28911486; rs2090153; rs34445751; rs11404899; rs35682038; rs4927629; rs35388919; rs34044289; rs11898092; rs12475212; rs28683616; rs28409666; rs11893496; rs3036105; rs2175979; rs28909413; rs35858346; rs28913268; rs34602774; rs34131144; rs3036079; rs4927620; rs28682482; rs13409826; rs35614838; rs34480829; rs12992385; rs28911479; rs28913025; rs35623494; rs28909995; rs36175402; rs13418129; rs13406835; rs34046827; rs28915681; rs11687965; rs35008230; rs13006236; rs5828824; rs34879368; rs28911169; rs9973952; rs13417585; rs28912976; rs13010957; rs9973955; rs13020631; rs35943116; rs28909398; rs13423107; rs28461932; rs13012709; rs28910593; rs13423282; rs4927596; rs13014527; rs10191653; rs34064729; rs11673992; rs9750163; rs9677530; rs28909404; rs4927626; rs13404230; rs7583423; rs28910569; rs35290486; rs2361747; rs13006630; rs10181396; rs9973911; rs28991282; rs28915682; rs28911489; rs28437028; rs5828823; rs28681289; rs13404488; rs28912997; rs10170298; rs28913015; rs13014542; rs13385523; rs13027419; rs11689386; rs35839340; rs13036125; rs28910009; rs34541512; rs34790485; rs28677046; rs28910596; rs34413535; rs34531889; rs28909370; rs11687810; rs9679416; rs34950864; rs2203399; rs34932469; rs10523977; rs11673953; rs34234148; rs12986550; rs28620935; rs2090152; rs13026363; rs28909409; rs28913026; rs28489465; rs35201002; rs13403910; rs34521796; rs28913027; rs11887001; rs35836927; rs28432167; rs10197112; rs28910592; rs28910570; rs7579188; rs34088587; rs11371261; rs13402950; rs12476325; rs12151527; rs28913002; rs4927595; rs10634971; rs35224341; rs35631326; rs13403265; rs2885359; rs28911477; rs13000185; rs28991286; rs28910004; rs11673934; rs28909405; rs13031191; rs28913032; rs28991291; rs28909985; rs28991569; rs35374888; rs10179394; rs28909984; rs13407296; rs10192959; rs10202105; rs10206900; rs10890517; rs11211645; rs11675342; rs11675434; rs11678852; rs11681698; rs11682968; rs11685159; rs11686524; rs11686775; rs11694732; rs12469603; rs12471910; rs12990372; rs13017252; rs13390616; rs13400534; rs13407974; rs13413096; rs13413987; rs13414537; rs13426896; rs1567920; rs17091606; rs17091611; rs17091616; rs17786733; rs1828864; rs2298873; rs2298874; rs35743195; rs6605278; rs6705087; rs9677074

# Metabolic_Enzyme_4_General_References:
3475693; 3453124; 2548579; 2308857; 12454013; 3654979; 2383265; 7550241; 9024270; 10468986; 10084596; 9924196; 11061528; 11415848; 11916616; 12213873; 11874711; 12938097

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5516

# Metabolic_Enzyme_5_Name:
Aspartate aminotransferase, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
Transaminase A; Glutamate oxaloacetate transaminase 2

# Metabolic_Enzyme_5_Gene_Name:
GOT2

# Metabolic_Enzyme_5_Protein_Sequence:
>Aspartate aminotransferase, mitochondrial precursor
MALLHSGRVLPGIAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEAFKRDTNSKKM
NLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENSEV
LKSGRFVTVQTISGTGALRIGASFLQRFFKFSRDVFLPKPTWGNHTPIFRDAGMQLQGYR
YYDPKTCGFDFTGAVEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIATVVKKRNLFA
FFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTMVCKDADE
AKRVESQLKILIRPMYSNPPLNGARIAAAILNTPDLRKQWLQEVKGMADRIIGMRTQLVS
NLKKEGSTHNWQHITDQIGMFCFTGLKPEQVERLIKEFSIYMTKDGRISVAGVTSSNVGY
LAHAIHQVTK

# Metabolic_Enzyme_5_Number_of_Residues:
430

# Metabolic_Enzyme_5_Molecular_Weight:
47476

# Metabolic_Enzyme_5_Theoretical_pI:
9.38

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  transaminase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_5_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00272  Cysteine metabolism;
 map00330  Arginine and proline metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00401  Novobiocin biosynthesis;
 map00710  Carbon fixation;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_5_Reaction:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_5_Signals:
1-24

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.6.1.1

# Metabolic_Enzyme_5_GenBank_ID_Protein:
179104

# Metabolic_Enzyme_5_SwissProt_ID:
AATM_HUMAN (P00505)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
GOT2

# Metabolic_Enzyme_5_Geneatlas_id:
GOT2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:4433

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_5_Gene_Sequence:
>1293 bp
ATGGCCCTGCTGCACTCCGGCCGCGTCCTCCCCGGGATCGCCGCCGCCTTCCACCCGGGC
CTCGCCGCCGCGGCCTCTGCCAGAGCCAGCTCCTGGTGGACCCATGTGGAAATGGGACCT
CCAGATCCCATTCTGGGAGTCACTGAAGCCTTTAAGAGGGACACCAATAGCAAAAAGATG
AATCTGGGAGTTGGTGCCTACCGGGATGATAATGGAAAGCCTTACGTTCTGCCTAGCGTC
CGCAAGGCAGAGGCCCAGATTGCCGCAAAAAATTTGGACAAGGAATACCTGCCCATTGGG
GGACTGGCTGAATTTTGCAAGGCATCTGCAGAACTAGCCCTGGGTGAGAACAGCGAAGTC
TTGAAGAGTGGCCGGTTTGTCACTGTGCAGACCATTTCTGGAACTGGAGCCTTAAGGATC
GGAGCCAGTTTTCTGCAAAGATTTTTTAAGTTCAGCCGAGATGTCTTTCTGCCCAAACCA
ACCTGGGGAAACCACACACCCATCTTCAGGGATGCTGGCATGCAGCTACAAGGTTATCGG
TATTATGACCCCAAGACTTGCGGTTTTGACTTCACAGGCGCTGTGGAGGATATTTCAAAA
ATACCAGAGCAGAGTGTTCTTCTTCTGCATGCCTGCGCCCACAATCCCACGGGAGTGGAC
CCGCGTCCGGAACAGTGGAAGGAAATAGCAACAGTGGTGAAGAAAAGGAATCTCTTTGCG
TTCTTTGACATGGCCTACCAAGGCTTTGCCAGTGGTGATGGTGATAAGGATGCCTGGGCT
GTGCGCCACTTCATCGAACAGGGCATTAATGTTTGCCTCTGCCAATCATATGCCAAGAAC
ATGGGCTTATATGGTGAGCGTGTAGGAGCCTTCACTATGGTCTGCAAAGATGCGGATGAA
GCCAAAAGGGTAGAGTCACAGTTGAAGATCTTGATCCGTCCCATGTATTCCAACCCTCCC
CTCAATGGGGCCCGGATTGCTGCTGCCATTCTGAACACCCCAGATTTGCGAAAACAATGG
CTGCAAGAAGTGAAAGGCATGGCTGACCGCATCATTGGCATGCGGACTCAACTGGTCTCC
AACCTCAAGAAGGAGGGTTCCACCCACAATTGGCAACACATCACCGACCAAATTGGCATG
TTCTGTTTCACAGGGCTAAAGCCTGAACAGGTGGAGCGGCTGATCAAGGAGTTCTCCATC
TACATGACAAAAGATGGCCGCATCTCTGTGGCAGGGGTCACCTCCAGCAACGTGGGCTAC
CTTGCCCATGCCATTCACCAGGTCACCAAGTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M22632

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_5_Locus:
16q21

# Metabolic_Enzyme_5_SNPs:
rs30842; rs11076256; rs257636; rs6993; rs7202491; rs11861897; rs257620; rs863944; rs6499971; rs30838; rs30839; rs7204324; rs257616; rs257630; rs1646256; rs8060056; rs6499970; rs30834; rs257617; rs185397; rs257634; rs12600277; rs257618; rs2304490; rs7196291; rs30837; rs9921563; rs1610878; rs4784975; rs9926132; rs257637; rs1646267; rs257631; rs13334922; rs1424245; rs30836; rs190473; rs257633; rs7186087; rs30835; rs173992; rs10500407; rs257649; rs187277; rs9926863; rs40574; rs183757; rs30843; rs1657179; rs7189519; rs1657178; rs2042445; rs7188608; rs257650; rs1803169; rs17849335; rs11558171; rs8059441; rs1058192; rs14221; rs11558167; rs1803168; rs28612351; rs3208672; rs1803170; rs7186105; rs35645687; rs5817158; rs11333258; rs34912264; rs10676089; rs1436429; rs35946557; rs4784974; rs8047219; rs12922626; rs34509416; rs257632; rs35502495; rs12919184; rs7184964; rs9934653; rs9921588; rs4784976; rs13334281; rs9921474; rs12597424; rs7185829; rs13330819; rs28497727; rs34526718; rs7204346; rs3217426; rs11348341; rs34853918; rs257621; rs30840; rs34039790; rs35247174; rs13337034; rs34792826; rs171786; rs30841; rs1657182; rs34180921; rs9923914; rs12921667; rs12933313; rs11299978; rs8046165; rs35323432; rs11423426; rs12932751; rs9933525; rs7186806; rs34289635; rs35324915; rs11439864; rs8046634; rs40575; rs11445492; rs28463297; rs5817159; rs35679170; rs34405351; rs9927670; rs257619; rs35298154; rs3743573; rs8045857; rs9933114; rs8044891; rs35125089; rs35939343; rs7187269; rs257638; rs7194323; rs12923759; rs28472773; rs839418; rs35327432; rs7189104; rs4273028; rs7199783; rs1646260; rs10563758; rs11643959; rs11644269; rs11644290; rs11647748; rs11647808; rs11859875; rs1473205; rs1473206; rs154435; rs1616798; rs1646268; rs3931747; rs4238801; rs4784054; rs4784977; rs6499969; rs7195214; rs7197245

# Metabolic_Enzyme_5_General_References:
3207426; 4052435

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5515

# Metabolic_Enzyme_6_Name:
Aspartate aminotransferase, cytoplasmic

# Metabolic_Enzyme_6_Synonyms:
Transaminase A; Glutamate oxaloacetate transaminase 1

# Metabolic_Enzyme_6_Gene_Name:
GOT1

# Metabolic_Enzyme_6_Protein_Sequence:
>Aspartate aminotransferase, cytoplasmic
MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQK
IANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFL
ARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLEN
APEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWA
IRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPP
AQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGM
FSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ

# Metabolic_Enzyme_6_Number_of_Residues:
413

# Metabolic_Enzyme_6_Molecular_Weight:
46248

# Metabolic_Enzyme_6_Theoretical_pI:
7.01

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  transaminase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_6_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00272  Cysteine metabolism;
 map00330  Arginine and proline metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00401  Novobiocin biosynthesis;
 map00710  Carbon fixation;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_6_Reaction:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.6.1.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
179067

# Metabolic_Enzyme_6_SwissProt_ID:
AATC_HUMAN (P17174)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
GOT1

# Metabolic_Enzyme_6_Geneatlas_id:
GOT1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:4432

# Metabolic_Enzyme_6_PDB_ID:
1AJS

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_6_Gene_Sequence:
>1242 bp
ATGGCACCTCCGTCAGTCTTTGCCGAGGTTCCGCAGGCCCAGCCTGTCCTGGTCTTCAAG
CTCACTGCCGACTTCAGGGAGGATCCGGACCCCCGCAAGGTCAACCTGGGAGTGGGAGCA
TATCGCACGGATGACTGCCATCCCTGGGTTTTGCCAGTAGTGAAGAAAGTGGAGCAGAAG
ATTGCTAATGACAATAGCCTAAATCACGAGTATCTGCCAATCCTGGGCCTGGCTGAGTTC
CGGAGCTGTGCTTCTCGTCTTGCCCTTGGGGATGACAGCCCAGCACTCAAGGAGAAGCGG
GTAGGAGGTGTGCAATCTTTGGGGGGAACAGGTGCACTTCGAATTGGAGCTGATTTCTTA
GCGCGTTGGTACAATGGAACAAACAACAAGAACACACCTGTCTATGTGTCCTCACCAACC
TGGGAGAATCACAATGCTGTGTTTTCCGCTGCTGGTTTTAAAGACATTCGGTCCTATCGC
TACTGGGATGCAGAGAAGAGAGGATTGGACCTCCAGGGCTTCCTGAATGATCTGGAGAAT
GCTCCTGAGTTCTCCATTGTTGTCCTCCACGCCTGTGCACACAACCCAACTGGGATTGAC
CCAACTCCGGAGCAGTGGAAGCAGATTGCTTCTGTCATGAAGCACCGGTTTCTGTTCCCC
TTCTTTGACTCAGCCTATCAGGGCTTCGCATCTGGAAACCTGGAGAGAGATGCCTGGGCC
ATTCGCTATTTTGTGTCTGAAGGCTTCGAGTTCTTCTGTGCCCAGTCCTTCTCCAAGAAC
TTCGGGCTCTACAATGAGAGAGTCGGGAATCTGACTGTGGTTGGAAAAGAACCTGAGAGC
ATCCTGCAAGTCCTTTCCCAGATGGAGAAGATCGTGCGGATTACTTGGTCCAATCCCCCC
GCCCAGGGAGCACGAATTGTGGCCAGCACCCTCTCTAACCCTGAGCTCTTTGAGGAATGG
ACAGGTAATGTGAAGACAATGGCTGACCGGATTCTGACCATGAGATCTGAACTCAGGGCA
CGACTAGAAGCCCTCAAAACCCCTGGGACCTGGAACCACATCACTGATCAAATTGGCATG
TTCAGCTTCACTGGGTTGAACCCCAAGCAGGTTGAGTATCTGGTCAATGAAAAGCACATC
TACCTGCTGCCAAGTGGTCGAATCAACGTGAGTGGCTTAACCACCAAAAATCTAGATTAC
GTGGCCACCTCCATCCATGAAGCAGTCACCAAAATCCAGTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M37400

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_6_Locus:
10q24.1-q25.1

# Metabolic_Enzyme_6_SNPs:
rs2234971; rs2641; rs11867; rs1126878; rs11190083; rs2862611; rs4328160; rs4919310; rs11813054; rs3793935; rs4919308; rs17111658; rs3750897; rs2275952; rs7906501; rs7918062; rs7067702; rs9971275; rs9971274; rs11190087; rs11594790; rs12571181; rs12249347; rs10883343; rs11819158; rs4353208; rs3763793; rs11190088; rs17569447; rs3793933; rs7921465; rs12253915; rs3793934; rs2494651; rs10883341; rs2862612; rs2490280; rs12768505; rs17111665; rs2862613; rs17569578; rs4567385; rs11815136; rs10883342; rs10748775; rs4919309; rs17491012; rs12253861; rs11190081; rs2862614; rs12217584; rs11815637; rs12766044; rs17111645; rs17111694; rs4919311; rs12411568; rs11557841; rs4564264; rs41290500; rs11557840; rs1126927; rs11190082; rs2642; rs1802509; rs1802508; rs41290498; rs34854950; rs12777843; rs35687189; rs11394746; rs34971146; rs34646712; rs35478605; rs34582301; rs3045656; rs12252840; rs35736782; rs11378738; rs7918037; rs41400447; rs7896693; rs5787336; rs9731375; rs35003844; rs11456562; rs11313874; rs12358477; rs10668892; rs12241455; rs41436049; rs5787337; rs9971276; rs35500142; rs35096443; rs11456561; rs2902275; rs7899976; rs13377085; rs12777646; rs10629267; rs12414885; rs35193236; rs11325628; rs12777641; rs34254460; rs1892505; rs12776735; rs12776369; rs4917866; rs12775973; rs11816599; rs6584274; rs33928164; rs10786543; rs7917808; rs11429814; rs35546038; rs10716499; rs35665184; rs11190090; rs34122561; rs2234894; rs10748774; rs10786545; rs11190080; rs11190094; rs1132364; rs11592057; rs11598504; rs17111699; rs17490682; rs2298315; rs2298316; rs2490281; rs2490283; rs2494652; rs2494653; rs2494654; rs2862610; rs34183428; rs3750896; rs3793931; rs3793932; rs4345898; rs4917862; rs4917864; rs4919307; rs7099391; rs7914408; rs7920356

# Metabolic_Enzyme_6_General_References:
1974457; 2241899

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5512

# Metabolic_Enzyme_7_Name:
Phenylalanine-4-hydroxylase

# Metabolic_Enzyme_7_Synonyms:
PAH; Phe-4- monooxygenase

# Metabolic_Enzyme_7_Gene_Name:
PAH

# Metabolic_Enzyme_7_Protein_Sequence:
>Phenylalanine4hydroxylase
MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDV
NLTHIESRPS
RLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVP
WFPRTIQELDRFANQILSYGA
ELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVE
YMEEEKKTWGTVFKTLKSLYKTHACYEYNHIF
PLLEKYCGFHEDNIPQLEDVSQFLQTC
TGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPE
PDICHELLGHVPLFSD
RSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSS
FGELQ
YCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYD
PYTQR
IEVLDNTQQLKILADSINSEIGILCSALQKIK

# Metabolic_Enzyme_7_Number_of_Residues:
452

# Metabolic_Enzyme_7_Molecular_Weight:
51863

# Metabolic_Enzyme_7_Theoretical_pI:
6.57

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  phenylalanine 4-monooxygenase activity
Function:  amine binding
Function:  amino acid binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  L-phenylalanine metabolism
Process:  L-phenylalanine catabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
L-phenylalanine + tetrahydrobiopterin + O(2) = L-tyrosine + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_7_Pathway:
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis

# Metabolic_Enzyme_7_Reaction:
L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF01842:ACT;
PF00351:Biopterin_H

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.14.16.1

# Metabolic_Enzyme_7_GenBank_ID_Protein:
189937

# Metabolic_Enzyme_7_SwissProt_ID:
PH4H_HUMAN (P00439)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
PAH

# Metabolic_Enzyme_7_Geneatlas_id:
PAH

# Metabolic_Enzyme_7_hgnc_id:
HGNC:8582

# Metabolic_Enzyme_7_PDB_ID:
2PHM

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>1359 bp

ATGTCCACTGCGGTCCTGGAAAACCCAGGCTTGGGCAGGAAACTCTCTGACTTTGGACA
GGAAACAAGCT
ATATTGAAGACAACTGCAATCAAAATGGTGCCATATCACTGATCTTCT
CACTCAAAGAAGAAGTTGGTGC
ATTGGCCAAAGTATTGCGCTTATTTGAGGAGAATGAT
GTAAACCTGACCCACATTGAATCTAGACCTTCT
CGTTTAAAGAAAGATGAGTATGAATT
TTTCACCCATTTGGATAAACGTAGCCTGCCTGCTCTGACAAACA
TCATCAAGATCTTGA
GGCATGACATTGGTGCCACTGTCCATGAGCTTTCACGAGATAAGAAGAAAGACAC
AGTG
CCCTGGTTCCCAAGAACCATTCAAGAGCTGGACAGATTTGCCAATCAGATTCTCAGCTAT
GGAGCG
GAACTGGATGCTGACCACCCTGGTTTTAAAGATCCTGTGTACCGTGCAAGACG
GAAGCAGTTTGCTGACA
TTGCCTACAACTACCGCCATGGGCAGCCCATCCCTCGAGTGG
AATACATGGAGGAAGAAAAGAAAACATG
GGGCACAGTGTTCAAGACTCTGAAGTCCTTG
TATAAAACCCATGCTTGCTATGAGTACAATCACATTTTT
CCACTTCTTGAAAAGTACTG
TGGCTTCCATGAAGATAACATTCCCCAGCTGGAAGACGTTTCTCAATTCC
TGCAGACTT
GCACTGGTTTCCGCCTCCGACCTGTGGCTGGCCTGCTTTCCTCTCGGGATTTCTTGGGTG
G
CCTGGCCTTCCGAGTCTTCCACTGCACACAGTACATCAGACATGGATCCAAGCCCATG
TATACCCCCGAA
CCTGACATCTGCCATGAGCTGTTGGGACATGTGCCCTTGTTTTCAGA
TCGCAGCTTTGCCCAGTTTTCCC
AGGAAATTGGCCTTGCCTCTCTGGGTGCACCTGATG
AATACATTGAAAAGCTCGCCACAATTTACTGGTT
TACTGTGGAGTTTGGGCTCTGCAAA
CAAGGAGACTCCATAAAGGCATATGGTGCTGGGCTCCTGTCATCC
TTTGGTGAATTACA
GTACTGCTTATCAGAGAAGCCAAAGCTTCTCCCCCTGGAGCTGGAGAAGACAGCCA
TCC
AAAATTACACTGTCACGGAGTTCCAGCCCCTGTATTACGTGGCAGAGAGTTTTAATGATG
CCAAGGA
GAAAGTAAGGAACTTTGCTGCCACAATACCTCGGCCCTTCTCAGTTCGCTAC
GACCCATACACCCAAAGG
ATTGAGGTCTTGGACAATACCCAGCAGCTTAAGATTTTGGC
TGATTCCATTAACAGTGAAATTGGAATCC
TTTGCAGTGCCCTCCAGAAAATAAAGTAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
K03020

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_7_Locus:
12q22-q24.2

# Metabolic_Enzyme_7_SNPs:
rs5030849; rs1042503; rs1126758; rs1801152; rs772897; rs2280615; rs1801153; rs2280616; rs1616681; rs1722387; rs940527; rs772893; rs937475; rs1722383; rs1522295; rs2251897; rs1718305; rs1722392; rs1617090; rs2133298; rs2245360; rs12425434; rs2270729; rs11111419; rs10860933; rs1718312; rs10860929; rs2242381; rs1722381; rs1498688; rs1718303; rs1498694; rs2252031; rs2247836; rs2251905; rs10860936; rs2037639; rs2056602; rs4646986; rs12580432; rs1522296; rs10860928; rs1522307; rs10778202; rs2712618; rs10860935; rs10512929; rs10860931; rs4764918; rs1718301; rs772896; rs1353766; rs11836916; rs1718307; rs798709; rs11111412; rs1357765; rs10778201; rs12297049; rs4264203; rs10860930; rs1522304; rs3847931; rs869916; rs7295308; rs1718300; rs772895; rs1391685; rs1718304; rs1718306; rs4646987; rs10778204; rs1915932; rs940528; rs937476; rs1814728; rs1722399; rs7310181; rs1072528; rs1568795; rs2251799; rs870072; rs3805120; rs12306510; rs937474; rs3805122; rs1718297; rs10778209; rs7964033; rs2251894; rs1353767; rs7131709; rs17842947; rs1718302; rs11111413; rs6539058; rs7485666; rs3847930; rs12302563; rs1568792; rs1718310; rs10860934; rs7295112; rs7295979; rs10778205; rs11838076; rs772894; rs1718298; rs7485659; rs1722382; rs10778208; rs1722389; rs12309781; rs7138986; rs12578292; rs2454388; rs11830620; rs3817446; rs11831257; rs11111408; rs7488136; rs7485655; rs11838082; rs7488937; rs12301066; rs34181115; rs34191345; rs3828473; rs772899; rs12309687; rs1718292; rs7958897; rs7958750; rs35774237; rs772898; rs1851381; rs10778203; rs11111411; rs10778207; rs12579415; rs11830089; rs10778200; rs3913258; rs12099586; rs12831013; rs1106703; rs11111414; rs12581989; rs17033372; rs7487151; rs1522306; rs3828474; rs1722390; rs11830010; rs2953059; rs11111410; rs7485683; rs10778206; rs12312872; rs12298125; rs10450750; rs12299182; rs11830600; rs10745953; rs1718311; rs10860932; rs1722401; rs2252026; rs7306260; rs2133296; rs4646988; rs7305565; rs17842946; rs1522305; rs1718299; rs7485331; rs1498691; rs1522299; rs17546516; rs4764917; rs9804733; rs1522297; rs17041406; rs9804734; rs9804735; rs17033310; rs17852373; rs5030860; rs5030850; rs5030844; rs5030859; rs5030853; rs5030845; rs5030841; rs5030858; rs5030846; rs5030857; rs5030842; rs5030847; rs5030856; rs5030843; rs5030848; rs5030854; rs1801145; rs17852374; rs1801146; rs1801147; rs1042575; rs35465699; rs7954004; rs1042517; rs2264807; rs12099867; rs2647897; rs35620841; rs3062641; rs36183603; rs36087290; rs34044682; rs12319699; rs11486309; rs28672962; rs34903440; rs7980371; rs34297779; rs2454390; rs5030855; rs12314561; rs5800541; rs12310461; rs7969007; rs11835429; rs36013270; rs34089141; rs1814727; rs35544736; rs28380089; rs11111416; rs5800545; rs34757647; rs11384108; rs3062683; rs11111403; rs10615224; rs2133295; rs11830601; rs2647898; rs34956913; rs28626587; rs7965426; rs12307398; rs3840258; rs34694965; rs2691046; rs2270730; rs2712619; rs5800539; rs35080156; rs36197099; rs12829528; rs12815628; rs12424675; rs34356627; rs34923793; rs12099657; rs12314229; rs5800540; rs2373950; rs34877550; rs1799970; rs2264808; rs3792590; rs10525182; rs2949366; rs4764717; rs34906755; rs34950520; rs36191797; rs34480214; rs7970760; rs10573967; rs34400076; rs34425560; rs35822536; rs1623295; rs34451887; rs1403053; rs35008014; rs3062642; rs11833762; rs3062651; rs7302089; rs10573968; rs7970836; rs34857170; rs36195189; rs36201576; rs7295778; rs11111415; rs11111404; rs12826510; rs2264805; rs7970576; rs5800538; rs34358876; rs12099871; rs34437790; rs11829260; rs34584245; rs2133297; rs1976893; rs1722391; rs1498692; rs34539983; rs3062690; rs35776069; rs11338333; rs28854495; rs10542654; rs10679406; rs36134134; rs2264624; rs28630510; rs2691045; rs28620071; rs1081847; rs10526127; rs1568791; rs3847932; rs5800537; rs10531439; rs35530192; rs1976895; rs5800543; rs28655776; rs12809761; rs35490165; rs11111409; rs12424546; rs2247184; rs12320836; rs34506832; rs1722384; rs11833709; rs2373951; rs5030852; rs35081455; rs34824304; rs35681476; rs35507682; rs1619404; rs10654199; rs35194286; rs35197515; rs35855475; rs2264625; rs1463823; rs11111405; rs11111418; rs2264806; rs35019215; rs11837660; rs34418090; rs5800535; rs5800536; rs12099868; rs11608454; rs11305173; rs34213541; rs34619720; rs12578276; rs35350743; rs2264623; rs34426190; rs35530065; rs35780730; rs12099870; rs35122890; rs7308175; rs1568793; rs2647899; rs12826142; rs28673013; rs35520828; rs28435260; rs28396626; rs28496869; rs2173444; rs1718309; rs12829846; rs2102005; rs5030861; rs34438405; rs34426240; rs34299540; rs3062645; rs4764919; rs12313998; rs7964941; rs34330841; rs35790027; rs5800542; rs12427231; rs12307663; rs7135561; rs28380242; rs1622379; rs10573966; rs35823784; rs12313245; rs1522298; rs12312033; rs36053636; rs34637625; rs34730283; rs34674687; rs9738302; rs35118563; rs35048664; rs7485315; rs17041408; rs1498690; rs35026116; rs1498689; rs5030654; rs10860925; rs11111402; rs17842962; rs34068029; rs4764916; rs7314670; rs7978669

# Metabolic_Enzyme_7_General_References:
2986678; 2461704; 9406548; 9843368; 9642259; 10694386; 11718561; 1679029; 2246858; 1301187; 8594560; 2840952; 2564729; 2615649; 1975559; 1671810; 2014802; 1672294; 1672290; 1679030; 1709636; 1358789; 1355066; 1363837; 1363838; 8406445; 8098245; 8068076; 8088845; 7833954; 8889583; 8889590; 9048935; 9101291; 9450897; 9521426; 9600453; 9452061; 9452062; 9792407; 9792411; 9852673; 10679941; 11326337; 11180595; 11385716; 11461196

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5509

# Metabolic_Enzyme_8_Name:
Tyrosine aminotransferase

# Metabolic_Enzyme_8_Synonyms:
L-tyrosine:2-oxoglutarate aminotransferase; TAT

# Metabolic_Enzyme_8_Gene_Name:
TAT

# Metabolic_Enzyme_8_Protein_Sequence:
>Tyrosine aminotransferase
MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAKKTFNPIRAIV
DNMKVKPNPNKTMISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGFLSSRE
EIASYYHCPEAPLEAKDVILTSGCSQAIDLCLAVLANPGQNILVPRPGFSLYKTLAESMG
IEVKLYNLLPEKSWEIDLKQLEYLIDEKTACLIVNNPSNPCGSVFSKRHLQKILAVAARQ
CVPILADEIYGDMVFSDCKYEPLATLSTDVPILSCGGLAKRWLVPGWRLGWILIHDRRDI
FGNEIRDGLVKLSQRILGPCTIVQGALKSILCRTPGEFYHNTLSFLKSNADLCYGALAAI
PGLRPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLVAEQSVHCLPATCFEYPNFIRVVI
TVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK

# Metabolic_Enzyme_8_Number_of_Residues:
454

# Metabolic_Enzyme_8_Molecular_Weight:
50400

# Metabolic_Enzyme_8_Theoretical_pI:
6.24

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  transaminase activity
Function:  tyrosine transaminase activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-sulfur lyase activity
Function:  1-aminocyclopropane-1-carboxylate synthase activity
 ||
>>>
Process:  aromatic amino acid family metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  amino acid catabolism
Process:  aromatic amino acid family catabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
L-tyrosine + 2-oxoglutarate = 4- hydroxyphenylpyruvate + L-glutamate

# Metabolic_Enzyme_8_Pathway:
map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00401  Novobiocin biosynthesis;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_8_Reaction:
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00155:Aminotran_1_2;
PF07706:TAT_ubiq

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.6.1.5

# Metabolic_Enzyme_8_GenBank_ID_Protein:
36713

# Metabolic_Enzyme_8_SwissProt_ID:
ATTY_HUMAN (P17735)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
TAT

# Metabolic_Enzyme_8_Geneatlas_id:
TAT

# Metabolic_Enzyme_8_hgnc_id:
HGNC:11573

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Not Available

# Metabolic_Enzyme_8_Gene_Sequence:
>1365 bp
ATGGACCCATACATGATTCAGATGAGCAGCAAAGGCAACCTCCCCTCAATTCTGGACGTG
CATGTCAACGTTGGTGGGAGAAGCTCTGTGCCGGGAAAAATGAAAGGCAGAAAGGCCAGG
TGGTCTGTGAGGCCCTCAGACATGGCCAAGAAAACTTTCAACCCCATCCGAGCCATTGTG
GACAACATGAAGGTGAAACCAAATCCAAACAAAACCATGATTTCCCTGTCCATTGGGGAC
CCTACTGTGTTTGGAAACCTGCCTACAGACCCTGAAGTTACCCAGGCAATGAAAGATGCC
CTGGACTCGGGCAAATATAATGGCTATGCCCCATCCATCGGCTTCCTATCCAGTCGGGAG
GAGATTGCTTCTTATTACCACTGTCCTGAGGCACCCCTAGAAGCTAAGGACGTCATTCTG
ACAAGTGGCTGCAGCCAAGCTATTGACCTTTGTTTAGCTGTGTTGGCCAACCCAGGGCAG
AACATCCTGGTTCCAAGACCTGGTTTCTCTCTCTACAAGACTCTGGCTGAGTCTATGGGA
ATTGAGGTCAAACTCTACAATTTGTTGCCAGAGAAATCTTGGGAAATTGACCTGAAACAA
CTGGAATATCTAATTGATGAAAAGACAGCTTGTCTCATTGTCAATAATCCATCAAACCCC
TGTGGGTCAGTGTTCAGCAAACGTCATCTTCAGAAGATTCTGGCAGTGGCTGCACGGCAG
TGTGTCCCCATCTTAGCTGATGAGATCTATGGAGACATGGTGTTTTCGGATTGCAAATAT
GAACCACTGGCCACCCTCAGCACCGATGTCCCCATCCTGTCCTGTGGAGGGCTGGCCAAG
CGCTGGCTGGTTCCTGGCTGGAGGTTGGGCTGGATCCTCATTCATGACCGAAGAGACATT
TTTGGCAATGAGATCCGAGATGGGCTGGTGAAGCTGAGTCAGCGCATTTTGGGACCCTGT
ACCATTGTCCAGGGAGCTCTGAAAAGCATCCTATGTCGCACCCCGGGAGAGTTTTACCAC
AACACTCTGAGCTTCCTCAAGTCCAATGCTGATCTCTGTTATGGGGCGTTGGCTGCCATC
CCTGGACTCCGGCCAGTCCGCCCTTCTGGGGCTATGTACCTCATGGTTGGAATTGAGATG
GAACATTTCCCAGAATTTGAGAACGATGTGGAGTTCACGGAGCGGTTAGTTGCTGAGCAG
TCTGTCCACTGCCTCCCAGCAACGTGCTTTGAGTACCCGAATTTCATCCGAGTGGTCATC
ACAGTCCCCGAGGTGATGATGCTGGAGGCGTGCAGCCGGATCCAGGAGTTCTGTGAGCAG
CACTACCATTGTGCTGAAGGCAGCCAGGAGGAGTGTGATAAATAG

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X52520

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_8_Locus:
16q22.1

# Metabolic_Enzyme_8_SNPs:
rs16973331; rs2432520; rs172650; rs2113223; rs2247603; rs2432519; rs9939332; rs13339247; rs13338868; rs16973337; rs1364210; rs1477386; rs2032921; rs3829537; rs2432521; rs3794689; rs2432522; rs11075889; rs8063455; rs1477387; rs9930543; rs11862798; rs16973344; rs34508506; rs12924334; rs11648913; rs2303226; rs3764308; rs34104038; rs36000068; rs35082722; rs34753286; rs2161674; rs8064108; rs1799881; rs3036400; rs3057106; rs8063793; rs34263853; rs1477388; rs34131262; rs1544808; rs1073060; rs12598228; rs1428834; rs1428835; rs2434886; rs4788809

# Metabolic_Enzyme_8_General_References:
1973834; 7908801; 7999802; 1357662

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5510

# Metabolic_Enzyme_9_Name:
Aromatic-L-amino-acid decarboxylase

# Metabolic_Enzyme_9_Synonyms:
AADC; DOPA decarboxylase; DDC

# Metabolic_Enzyme_9_Gene_Name:
DDC

# Metabolic_Enzyme_9_Protein_Sequence:
>AromaticLaminoacid decarboxylase
MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV
EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD
WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM
EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV
ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN
PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL
KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN
EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE


# Metabolic_Enzyme_9_Number_of_Residues:
480

# Metabolic_Enzyme_9_Molecular_Weight:
53895

# Metabolic_Enzyme_9_Theoretical_pI:
7.21

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
 ||
>>>
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine

# Metabolic_Enzyme_9_Pathway:
map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00901  Indole and ipecac alkaloid biosynthesis;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_9_Reaction:
L-tryptophan = tryptamine + CO2

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00282:Pyridoxal_deC

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 4.1.1.28

# Metabolic_Enzyme_9_GenBank_ID_Protein:
181521

# Metabolic_Enzyme_9_SwissProt_ID:
DDC_HUMAN (P20711)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
DDC

# Metabolic_Enzyme_9_Geneatlas_id:
DDC

# Metabolic_Enzyme_9_hgnc_id:
HGNC:2719

# Metabolic_Enzyme_9_PDB_ID:
1JS3

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Not Available

# Metabolic_Enzyme_9_Gene_Sequence:
>1443 bp
ATGAACGCAAGTGAATTCCGAAGGAGAGGGAAGGAGATGGTGGATTACGTGGCCAACTAC
ATGGAAGGCATTGAGGGACGCCAGGTCTACCCTGACGTGGAGCCCGGGTACCTGCGGCCG
CTGATCCCTGCCGCTGCCCCTCAGGAGCCAGACACGTTTGAGGACATCATCAACGACGTT
GAGAAGATAATCATGCCTGGGGTGACGCACTGGCACAGCCCCTACTTCTTCGCCTACTTC
CCCACTGCCAGCTCGTACCCGGCCATGCTTGCGGACATGCTGTGCGGGGCCATTGGCTGC
ATCGGCTTCTCCTGGGCGGCAAGCCCAGCATGCACAGAGCTGGAGACTGTGATGATGGAC
TGGCTCGGGAAGATGCTGGAACTACCAAAGGCATTTTTGAATGAGAAAGCTGGAGAAGGG
GGAGGAGTGATCCAGGGAAGTGCCAGTGAAGCCACCCTGGTGGCCCTGCTGGCCGCTCGG
ACCAAAGTGATCCATCGGCTGCAGGCAGCGTCCCCAGAGCTCACACAGGCCGCTATCATG
GAGAAGCTGGTGGCTTACTCATCCGATCAGGCACACTCCTCAGTGGAAAGAGCTGGGTTA
ATTGGTGGAGTGAAATTAAAAGCCATCCCCTCAGATGGCAACTTCGCCATGCGTGCGTCT
GCCCTGCAGGAAGCCCTGGAGAGAGACAAAGCGGCTGGCCTGATTCCTTTCTTTATGGTT
GCCACCCTGGGGACCACAACATGCTGCTCCTTTGACAATCTCTTAGAAGTCGGTCCTATC
TGCAACAAGGAAGACATATGGCTGCACGTTGATGCAGCCTACGCAGGCAGTGCATTCATC
TGCCCTGAGTTCCGGCACCTTCTGAATGGAGTGGAGTTTGCAGATTCATTCAACTTTAAT
CCCCACAAATGGCTATTGGTGAATTTTGACTGTTCTGCCATGTGGGTGAAAAAGAGAACA
GACTTAACGGGAGCCTTTAGACTGGACCCCACTTACCTGAAGCACAGCCATCAGGATTCA
GGGCTTATCACTGACTACCGGCATTGGCAGATACCACTGGGCAGAAGATTTCGCTCTTTG
AAAATGTGGTTTGTATTTAGGATGTATGGAGTCAAAGGACTGCAGGCTTATATCCGCAAG
CATGTCCAGCTGTCCCATGAGTTTGAGTCACTGGTGCGCCAGGATCCCCGCTTTGAAATC
TGTGTGGAAGTCATTCTGGGGCTTGTCTGCTTTCGGCTAAAGGGTTCCAACAAAGTGAAT
GAAGCTCTTCTGCAAAGAATAAACAGTGCCAAAAAAATCCACTTGGTTCCATGTCACCTC
AGGGACAAGTTTGTCCTGCGCTTTGCCATCTGTTCTCGCACGGTGGAATCTGCCCATGTG
CAGCGGGCCTGGGAACACATCAAAGAGCTGGCGGCCGACGTGCTGCGAGCAGAGAGGGAG
TAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
M76180

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_9_Locus:
7p11

# Metabolic_Enzyme_9_SNPs:
rs6263; rs6262; rs11575542; rs11575292; rs6264; rs11575302; rs11575290; rs921451; rs2329342; rs2329371; rs10499694; rs1451374; rs10276473; rs6949897; rs4452748; rs921450; rs7803440; rs7803788; rs1470747; rs1451375; rs6969081; rs1966839; rs7803903; rs10249420; rs1451373; rs10265930; rs10499695; rs7786398; rs11575548; rs11974297; rs10250513; rs11575551; rs1349491; rs11575549; rs2060762; rs11575288; rs2329341; rs2329343; rs11575286; rs11575550; rs6593002; rs3779074; rs2242041; rs3837091; rs2329340; rs11765748; rs3779075; rs2044859; rs10499696; rs7779110; rs2876830; rs2242042; rs3779076; rs4947644; rs11765109; rs930707; rs11575282; rs11575273; rs17133881; rs4585697; rs11575544; rs17133878; rs10255505; rs11575281; rs6956737; rs11575543; rs11575545; rs2060761; rs11575553; rs6962356; rs11575546; rs10229387; rs11575552; rs11575284; rs11575280; rs6972476; rs11575547; rs6975312; rs998850; rs730092; rs896309; rs880028; rs1376524; rs745043; rs6592962; rs10899734; rs7790758; rs3887825; rs3735274; rs6965432; rs4948196; rs11761683; rs11238134; rs10899735; rs1451371; rs3807556; rs4947580; rs6951323; rs6950777; rs4580999; rs9942686; rs10277662; rs4947584; rs2198144; rs6592961; rs3779078; rs11983581; rs1037351; rs4436083; rs1901312; rs3807552; rs11983757; rs1451372; rs2167364; rs11772714; rs4947577; rs11575457; rs11768267; rs11575334; rs3735273; rs7809758; rs11575320; rs11980368; rs4377912; rs6957607; rs4947582; rs7776816; rs11981575; rs11575464; rs4948201; rs6967361; rs1451370; rs11575536; rs6944090; rs17133853; rs2876827; rs11575340; rs10244632; rs11575489; rs6592952; rs6952023; rs10228056; rs896308; rs11974997; rs11575518; rs4602840; rs11575378; rs11575527; rs11575375; rs12718541; rs11575387; rs745042; rs1817074; rs4579483; rs7791875; rs2122822; rs11575399; rs11575511; rs4947535; rs11575351; rs1376523; rs4992502; rs6947293; rs11575435; rs11575407; rs11575338; rs11575516; rs11763837; rs11575400; rs17133842; rs11575520; rs7777600; rs4397355; rs1901311; rs10274275; rs11575451; rs11575538; rs4948197; rs11575388; rs4947634; rs12667533; rs10268819; rs11575441; rs11575506; rs3779084; rs6974583; rs17133877; rs12718527; rs3807566; rs6979229; rs11238138; rs10499693; rs11982708; rs1982406; rs2329367; rs2100280; rs11238133; rs3807555; rs11575461; rs2876829; rs7803247; rs10899736; rs6951648; rs1007702; rs11575500; rs11771818; rs11575444; rs11575541; rs4329234; rs11575442; rs10239830; rs9918702; rs11575501; rs1007749; rs11575494; rs4947576; rs11575523; rs7780360; rs6963534; rs11982772; rs11575309; rs4947581; rs11575462; rs1349492; rs732215; rs11575322; rs2329365; rs10271341; rs4989851; rs3807558; rs11575298; rs4433100; rs11575537; rs731689; rs4490786; rs4245549; rs896307; rs17634958; rs3757472; rs4470989; rs11238131; rs11575535; rs11982776; rs7808025; rs3807562; rs11575404; rs2122817; rs11575522; rs6592963; rs5884156; rs3807553; rs10249982; rs11575510; rs1470750; rs4947631; rs11575463; rs12718572; rs12535024; rs2329366; rs11575383; rs6955487; rs2122821; rs17665398; rs11765543; rs7809477; rs12538938; rs11575327; rs11575521; rs1451369; rs12112308; rs11575360; rs17553495; rs11575454; rs1817073; rs11575447; rs2167367; rs3823674; rs11575450; rs11575507; rs11575319; rs11575301; rs17152014; rs10239937; rs6970468; rs11575295; rs7785224; rs4947621; rs17733244; rs3470; rs4449741; rs11575532; rs11575460; rs2167366; rs17634717; rs3779083; rs11575423; rs11575504; rs880029; rs17553791; rs6952381; rs11575502; rs9918591; rs11575406; rs11771860; rs11575519; rs1451368; rs2122818; rs11575372; rs11575343; rs11575300; rs11575368; rs11575381; rs13222408; rs11575509; rs12718574; rs11575455; rs11575540; rs11768997; rs7797142; rs17635123; rs7792578; rs11575515; rs11575526; rs11575491; rs11767384; rs6953675; rs7807564; rs11575385; rs2329364; rs11575332; rs11575512; rs11575296; rs12665948; rs11575428; rs11575305; rs11575323; rs11575503; rs11575339; rs11575449; rs6964142; rs2122819; rs11575304; rs2876826; rs11575342; rs11767334; rs11575456; rs17152020; rs11575472; rs4948225; rs11575313; rs3807563; rs7792474; rs11575525; rs11978797; rs10267323; rs2329368; rs11575424; rs2100279; rs11575434; rs6963996; rs11575513; rs11575534; rs11763051; rs11575411; rs11575392; rs11575425; rs11575505; rs11575328; rs17665588; rs11575431; rs4947625; rs6592969; rs11575349; rs11575353; rs2060763; rs12718528; rs11575293; rs11575492; rs6944912; rs11575356; rs2329369; rs11575429; rs11575438; rs7802199; rs3887826; rs11575453; rs11575414; rs11575321; rs2876828; rs12535064; rs7812167; rs6592973; rs11575508; rs1807066; rs1304691; rs11575437; rs11575514; rs17634771; rs1466163; rs11575374; rs7809234; rs3779082; rs11575430; rs12671474; rs11575422; rs7810677; rs3071970; rs11575446; rs11575410; rs11575325; rs2167363; rs17665670; rs13311361; rs11575352; rs11575483; rs11575413; rs7778349; rs6975453; rs11575359; rs12718529; rs1451366; rs11575531; rs11575493; rs1597639; rs11575528; rs4948010; rs4947510; rs3829897; rs11575575; rs6593010; rs11575557; rs4947511; rs11575565; rs11575568; rs11575564; rs11575574; rs11575266; rs10278338; rs11575562; rs11575259; rs11575264; rs11575561; rs11575570; rs11575271; rs11575566; rs11575569; rs11575267; rs11575556; rs11575268; rs11575376; rs11575377; rs11575291; rs12670911; rs10233346; rs11575274; rs28607134; rs28799122; rs34618339; rs13223166; rs11302809; rs4515495; rs10281167; rs34752519; rs2242040; rs13223157; rs13233973; rs13245496; rs2242039; rs5884158; rs13237075; rs2329370; rs28510954; rs10600316; rs10229102; rs13226079; rs3071145; rs11366731; rs10601831; rs35197006; rs7791943; rs2242038; rs5014165; rs13226287; rs7782081; rs12718674; rs11575276; rs2167368; rs10255145; rs11575277; rs34606153; rs6975015; rs11410259; rs10229369; rs10247443; rs11575275; rs10609620; rs7787209; rs13245018; rs34348593; rs1988550; rs35330002; rs35591152; rs11450560; rs11575468; rs34658291; rs11575395; rs35299591; rs34021747; rs35586188; rs11575432; rs34314851; rs35089176; rs35997922; rs12537169; rs12718558; rs11575294; rs1470749; rs11315611; rs11575315; rs13228083; rs35582115; rs4947588; rs13308328; rs3779077; rs3807554; rs5884157; rs7811992; rs12718563; rs36110443; rs11575482; rs11330628; rs1107742; rs731690; rs11575433; rs4948216; rs11575311; rs11575326; rs6965025; rs11575347; rs11575474; rs11575316; rs11575459; rs35993062; rs3840579; rs11575314; rs11575465; rs5884154; rs3779080; rs34950596; rs2198143; rs10718396; rs10587155; rs36090705; rs34869137; rs11575533; rs3071964; rs13234331; rs34002033; rs1137337; rs34977933; rs3779081; rs35173748; rs1470748; rs12538830; rs4947594; rs11575497; rs35008528; rs4947589; rs2084723; rs11575306; rs34971815; rs34780941; rs13222708; rs11575346; rs1107743; rs6953661; rs12718583; rs11575329; rs6959596; rs36104801; rs7794360; rs11763809; rs13244875; rs11575362; rs11575415; rs28889020; rs35666388; rs35765995; rs6968322; rs11575389; rs11761208; rs33974864; rs6975747; rs13232900; rs34329145; rs11575369; rs7810684; rs11978769; rs4143196; rs28706313; rs3071975; rs7781950; rs28534613; rs12718611; rs4377913; rs1580031; rs5884155; rs28531762; rs34984600; rs11309882; rs11575318; rs35539624; rs11575333; rs36063027; rs11980236; rs7785984; rs35432113; rs34298125; rs11575363; rs7455902; rs7786752; rs10258321; rs34582666; rs11575397; rs11575530; rs4455783; rs11575529; rs11575312; rs33945116; rs4948205; rs1304693; rs11575401; rs35915381; rs2122820; rs34487683; rs11763807; rs13225182; rs6960966; rs34791889; rs36005269; rs11575303; rs6952938; rs6964313; rs10710723; rs11575417; rs1901313; rs11378977; rs11575524; rs11575394; rs13229021; rs11575308; rs11575348; rs12666643; rs11575499; rs35269833; rs11575393; rs11575330; rs4052336; rs3071963; rs11575458; rs11575367; rs13228086; rs35484306; rs7793185; rs11575390; rs12537186; rs35092758; rs3807557; rs11575555; rs11575554; rs11575269; rs11575567; rs11575257; rs11575559; rs11575265; rs11575261; rs11575571; rs11575270; rs11575572; rs35937247; rs11575260; rs4947662; rs13243080; rs11575563; rs35517528; rs10499697; rs11238214; rs11489734; rs11977135; rs12666409; rs13228274; rs3911193; rs4947396; rs6593011; rs7790230; rs7804365; rs7807335; rs978784

# Metabolic_Enzyme_9_General_References:
2590185; 1612608; 1540578; 8510497; 1395716; 10391209

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5319

# Metabolic_Enzyme_10_Name:
Tyrosinase precursor

# Metabolic_Enzyme_10_Synonyms:
Monophenol monooxygenase; Tumor rejection antigen AB; SK29-AB; LB24-AB

# Metabolic_Enzyme_10_Gene_Name:
TYR

# Metabolic_Enzyme_10_Protein_Sequence:
>Tyrosinase precursor
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILL
SNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVR
RNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMH
YYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRD
AEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRN
PGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQS
SMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGH
NRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLG
AAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL

# Metabolic_Enzyme_10_Number_of_Residues:
529

# Metabolic_Enzyme_10_Molecular_Weight:
60394

# Metabolic_Enzyme_10_Theoretical_pI:
6.05

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Not Available

# Metabolic_Enzyme_10_Specific_Function:
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone

# Metabolic_Enzyme_10_Pathway:
map00350  Tyrosine metabolism;
 map00740  Riboflavin metabolism;
 map00940  Stilbene, coumarine and lignin biosynthesis;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_10_Reaction:
L-tyrosine + L-dopa + O2 = L-dopa + dopaquinone + H2O

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00264:Tyrosinase

# Metabolic_Enzyme_10_Signals:
1-18

# Metabolic_Enzyme_10_Transmembrane_Regions:
477-497

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 1.14.18.1

# Metabolic_Enzyme_10_GenBank_ID_Protein:
340037

# Metabolic_Enzyme_10_SwissProt_ID:
TYRO_HUMAN (P14679)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
TYR

# Metabolic_Enzyme_10_Geneatlas_id:
TYR

# Metabolic_Enzyme_10_hgnc_id:
HGNC:12442

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Melanosome; melanosomal membrane; single- pass type I membrane protein

# Metabolic_Enzyme_10_Gene_Sequence:
>1590 bp
ATGCTCCTGGCTGTTTTGTACTGCCTGCTGTGGAGTTTCCAGACCTCCGCTGGCCATTTC
CCTAGAGCCTGTGTCTCCTCTAAGAACCTGATGGAGAAGGAATGCTGTCCACCGTGGAGC
GGGGACAGGAGTCCCTGTGGCCAGCTTTCAGGCAGAGGTTCCTGTCAGAATATCCTTCTG
TCCAATGCACCACTTGGGCCTCAATTTCCCTTCACAGGGGTGGATGACCGGGAGTCGTGG
CCTTCCGTCTTTTATAATAGGACCTGCCAGTGCTCTGGCAACTTCATGGGATTCAACTGT
GGAAACTGCAAGTTTGGCTTTTGGGGACCAAACTGCACAGAGAGACGACTCTTGGTGAGA
AGAAACATCTTCGATTTGAGTGCCCCAGAGAAGGACAAATTTTTTGCCTACCTCACTTTA
GCAAAGCATACCATCAGCTCAGACTATGTCATCCCCATAGGGACCTATGGCCAAATGAAA
AATGGATCAACACCCATGTTTAACGACATCAATATTTATGACCTCTTTGTCTGGATGCAT
TATTATGTGTCAATGGATGCACTGCTTGGGGGATCTGAAATCTGGAGAGACATTGATTTT
GCCCATGAAGCACCAGCTTTTCTGCCTTGGCATAGACTCTTCTTGTTGCGGTGGGAACAA
GAAATCCAGAAGCTGACAGGAGATGAAAACTTCACTATTCCATATTGGGACTGGCGGGAT
GCAGAAAAGTGTGACATTTGCACAGATGAGTACATGGGAGGTCAGCACCCCACAAATCCT
AACTTACTCAGCCCAGCATCATTCTTCTCCTCTTGGCAGATTGTCTGTAGCCGATTGGAG
GAGTACAACAGCCATCAGTCTTTATGCAATGGAACGCCCGAGGGACCTTTACGGCGTAAT
CCTGGAAACCATGACAAATCCAGAACCCCAAGGCTCCCCTCTTCAGCTGATGTAGAATTT
TGCCTGAGTTTGACCCAATATGAATCTGGTTCCATGGATAAAGCTGCCAATTTCAGCTTT
AGAAATACACTGGAAGGATTTGCTAGTCCACTTACTGGGATAGCGGATGCCTCTCAAAGC
AGCATGCACAATGCCTTGCACATCTATATGAATGGAACAATGTCCCAGGTACAGGGATCT
GCCAACGATCCTATCTTCCTTCTTCACCATGCATTTGTTGACAGTATTTTTGAGCAGTGG
CTCCGAAGGCACCGTCCTCTTCAAGAAGTTTATCCAGAAGCCAATGCACCCATTGGACAT
AACCGGGAATCCTACATGGTTCCTTTTATACCACTGTACAGAAATGGTGATTTCTTTATT
TCATCCAAAGATCTGGGCTATGACTATAGCTATCTACAAGATTCAGACCCAGACTCTTTT
CAAGACTACATTAAGTCCTATTTGGAACAAGCGAGTCGGATCTGGTCATGGCTCCTTGGG
GCGGCGATGGTAGGGGCCGTCCTCACTGCCCTGCTGGCAGGGCTTGTGAGCTTGCTGTGT
CGTCACAAGAGAAAGCAGCTTCCTGAAGAAAAGCAGCCACTCCTCATGGAGAAAGAGGAT
TACCACAGCTTGTATCAGAGCCATTTATAA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
M27160

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_10_Locus:
11q14-q21

# Metabolic_Enzyme_10_SNPs:
rs33955261; rs1042602; rs1126809; rs1042608; rs4987234; rs3913543; rs3913544; rs1502267; rs3913542; rs1827430; rs1432447; rs12799137; rs2186640; rs12273884; rs6483004; rs11018524; rs12803764; rs621313; rs7358418; rs7117973; rs7929991; rs11018541; rs6483000; rs11820797; rs10765196; rs11824837; rs4753215; rs11018528; rs12420237; rs1393350; rs12804012; rs4399330; rs7108676; rs6483008; rs6483001; rs12419949; rs1939258; rs7940773; rs7945829; rs6483006; rs591260; rs574028; rs7929015; rs12419351; rs12808785; rs6483002; rs4396293; rs501301; rs3900053; rs11018530; rs7115192; rs6483007; rs7123654; rs7940760; rs10765197; rs9919559; rs3793974; rs16913104; rs1847142; rs7943909; rs16913107; rs7107143; rs17793750; rs7111110; rs12418383; rs1939253; rs4121403; rs7947262; rs2000554; rs12420674; rs12416719; rs1847134; rs12419364; rs7115568; rs11018525; rs12418646; rs7941532; rs11820635; rs7105390; rs12419262; rs16912259; rs6483003; rs2866556; rs12808381; rs7123206; rs3793976; rs10765200; rs10830241; rs12791412; rs12786274; rs16913039; rs2000553; rs7112373; rs7927996; rs7941110; rs12417182; rs12420662; rs11823675; rs10830250; rs7941686; rs12420278; rs4121401; rs7117190; rs12421397; rs4418813; rs12807810; rs12789914; rs10765198; rs10741305; rs12808354; rs12421155; rs12417077; rs12418148; rs11824443; rs10765201; rs2002720; rs1942493; rs12098971; rs12806466; rs7101897; rs1939255; rs2298458; rs17174064; rs7924589; rs11018544; rs10501700; rs12421402; rs12417632; rs3793975; rs7117826; rs10830253; rs17191474; rs12419341; rs12420348; rs594647; rs7129973; rs12280928; rs7117213; rs16912972; rs16912981; rs11018522; rs12417166; rs7103781; rs12280693; rs11820834; rs10830245; rs1939262; rs12799347; rs7933595; rs10830248; rs12808219; rs7942587; rs12421746; rs12574987; rs7940368; rs4601783; rs16913084; rs12420864; rs12419071; rs7116589; rs16913095; rs10501698; rs11018549; rs12416958; rs7925659; rs7358330; rs12270717; rs12365043; rs12421030; rs12577992; rs16912983; rs11018555; rs12793071; rs11018545; rs11018535; rs16912966; rs11828655; rs7947052; rs11828731; rs12795158; rs3936992; rs1939263; rs9919546; rs4290229; rs660491; rs10830240; rs7933594; rs16912262; rs7117255; rs11821815; rs575429; rs10830249; rs6482999; rs1074304; rs10830244; rs11018542; rs11018548; rs17793678; rs645592; rs11018553; rs12799516; rs598769; rs10765199; rs4087499; rs16913089; rs10501699; rs16913011; rs1939251; rs4753214; rs7935604; rs11018543; rs12421505; rs10830239; rs12417327; rs11018532; rs7939929; rs6415994; rs2000555; rs12795171; rs7925468; rs2155148; rs7103787; rs16913040; rs11018562; rs1939252; rs12286618; rs7116973; rs12363772; rs10830243; rs12808283; rs7943159; rs16912994; rs7116716; rs7936840; rs9736253; rs4512823; rs3936623; rs7929736; rs11018539; rs535527; rs2155149; rs2155147; rs12803765; rs877072; rs10830247; rs10830246; rs7934212; rs12417026; rs7117974; rs6485980; rs10830238; rs12799768; rs7924913; rs525883; rs12418178; rs12288824; rs12792733; rs12799349; rs4542415; rs12792959; rs1892924; rs4547091; rs1799989; rs5021654; rs7930949; rs7940945; rs28940878; rs13312744; rs13312739; rs34297847; rs34878847; rs13312741; rs28940880; rs11545463; rs13312740; rs11826502; rs11824499; rs11545464; rs28940877; rs28940879; rs36006590; rs28940876; rs28940881; rs13312743; rs1939261; rs1939260; rs35541275; rs1800421; rs13312738; rs34814690; rs11453031; rs36041295; rs1939254; rs7121593; rs34175287; rs7951381; rs11018554; rs35062445; rs34947445; rs34656455; rs11411684; rs28634864; rs11018559; rs11018540; rs34017963; rs34698766; rs2134299; rs12788302; rs35963892; rs12786392; rs11018547; rs36137175; rs1060297; rs34202080; rs12788985; rs12365772; rs12578000; rs35218219; rs12788993; rs11018560; rs4121402; rs35026809; rs35311585; rs4121397; rs5793396; rs17852431; rs36124916; rs7929045; rs4561218; rs34486762; rs34289520; rs35905469; rs34003066; rs4429061; rs34661861; rs4987235; rs12796520; rs34703992; rs28578270; rs34373463; rs11018523; rs34739346; rs12786829; rs905283; rs5793397; rs12277937; rs11018527; rs34899701; rs34429128; rs34758368; rs34773602; rs1074303; rs36055732; rs12803508; rs13312742; rs16913082; rs36007597; rs12804213; rs35654391; rs10526067; rs28620862; rs12791524; rs35555968; rs11018536; rs7396600; rs10551522; rs34876778; rs11018556; rs1783963; rs35928779; rs7946027; rs12786751; rs7924312; rs4079453; rs4087500; rs3907204; rs35930733; rs35724269; rs12804722; rs7934646; rs35477235; rs35801536; rs34425156; rs41320146; rs1939257; rs12789480; rs34675404; rs12805094; rs11018550; rs35501966; rs35514600; rs34903891; rs12803535; rs12294360; rs4512825; rs34634444; rs592486; rs17852430; rs35663695; rs10573250; rs12788260; rs35032790; rs34621048; rs12099254; rs34873297; rs694934; rs34700959; rs4611200; rs7127196; rs35103430; rs35217407; rs35464565; rs5793398; rs10547762; rs16913085; rs34422026; rs7928821; rs35222097; rs34604882; rs609630; rs12796336; rs10671315; rs35457014; rs12271965; rs7946211; rs12805443; rs35434176; rs12789834; rs4121400; rs12146614; rs35105852; rs3907205; rs35774080; rs35744603; rs1939256; rs35428928; rs648871; rs35937494; rs582480; rs12786390; rs625401; rs11018563; rs12797237; rs636613; rs12788232; rs12807511; rs35959534; rs34067617; rs36098386; rs12788214; rs35518533; rs7112858; rs5793399; rs34584385; rs35607520; rs11018557; rs12805030; rs12574349; rs2008320; rs516696; rs35526885; rs12805221; rs35342940; rs11018551; rs1847136; rs11018538; rs11018546; rs34530512; rs34857319; rs35029283; rs11018534; rs1074305; rs35523924; rs12789159; rs35300336; rs11517465; rs603082; rs34295137; rs28826427; rs34469199; rs12787683; rs35430241; rs35115224; rs35597809; rs12295166; rs4614456; rs905281; rs10583155; rs35770150; rs34754918; rs7924785; rs35581621; rs1987513; rs12786588; rs2173998; rs33998063; rs12285584; rs12805029; rs11381844; rs12099178; rs11018558; rs28625671; rs4121398; rs35531191; rs649687; rs7927845; rs34029150; rs35008750; rs7122606; rs475629; rs34865967; rs34625776; rs35549872; rs4121399; rs35764186; rs3834913; rs7483274; rs11018526; rs12786201; rs1939259; rs28625370; rs35804290; rs34388247; rs16912961; rs35195697; rs7105284; rs35638921; rs7119171; rs12364170; rs10691193; rs28521275; rs11374501; rs10830237; rs11824466; rs11827921; rs12795279; rs1954771; rs35402334; rs7949856; rs949537; rs949538

# Metabolic_Enzyme_10_General_References:
1903356; 2823263; 2499655; 1711223; 8340755; 11153699; 2480811; 2504160; 11214319; 8477259; 10094567; 2342539; 1970634; 1903591; 1642278; 1899321; 1900309; 1943686; 1487241; 7902671; 8128955; 7955413; 8644824; 9158138; 9259202; 10987646; 10571953; 11295837; 11858948

# Metabolic_Enzyme_10_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8846

# Macromolecular_Interacting_Partner_1_Name:
OTTHUMP00000017019

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
SLC16A10

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>
OTTHUMP00000017019WVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLM
SSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILL
PLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRKKFS
PPKKIFNFAIFKVTAYAVWAVGIPLALFGYFVPYVHLAKFSFVILKYE

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
210

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
23037

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
9.91

# Macromolecular_Interacting_Partner_1_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_1_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF07690:MFS_1

# Macromolecular_Interacting_Partner_1_Signals:
1-21

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
5-24; 31-50; 55-77; 84-106; 116-136; 175-197

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
55664353

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
Q5VWW7_HUMAN (Q5VWW7)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
SLC16A10

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
SLC16A10

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:17027

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1548 bp
ATGGTGCTCTCCCAGGAGGAGCCGGACTCCGCGCGGGGCACGAGCGAGGCGCAGCCGCTC
GGCCCCGCGCCCACGGGGGCCGCTCCGCCGCCCGGCCCGGGACCCTCGGACAGCCCCGAG
GCGGCTGTCGAGAAGGTGGAGGTGGAGCTGGCGGGGCCGGCGACCGCGGAGCCCCATGAG
CCCCCCGAACCCCCCGAGGGCGGCTGGGGCTGGCTGGTGATGCTGGCGGCCATGTGGTGC
AACGGGTCGGTGTTCGGCATCCAGAACGCTTGCGGGGTGCTCTTCGTGTCCATGCTGGAA
ACCTTCGGCTCCAAAGACGATGACAAGATGGTCTTTAAGACAGCATGGGTAGGTTCTCTC
TCCATGGGGATGATTTTCTTTTGCTGCCCAATAGTCAGCGTCTTCACAGACCTATTTGGT
TGTCGGAAAACAGCTGTCGTGGGTGCTGCTGTTGGATTTGTTGGGCTCATGTCCAGTTCT
TTTGTAAGTTCCATCGAGCCTCTGTACCTTACCTATGGAATCATATTTGCCTGCGGCTGC
TCCTTTGCATACCAGCCTTCATTGGTCATTTTGGGACACTATTTCAAGAAGCGCCTTGGA
CTGGTGAATGGCATTGTCACTGCTGGCAGCAGTGTCTTCACAATCCTGCTGCCTTTGCTC
TTAAGGGTTCTGATTGACAGCGTGGGCCTCTTTTACACATTGAGGGTGCTCTGCATCTTC
ATGTTTGTTCTCTTTCTGGCTGGCTTTACTTACCGACCTCTTGCTACCAGTACCAAAGAT
AAAGAGAGTGGAGGTAGCGGATCCTCCCTCTTTTCCAGGAAAAAGTTCAGTCCTCCAAAA
AAAATTTTCAATTTTGCCATCTTCAAGGTGACAGCTTATGCAGTGTGGGCAGTTGGAATA
CCACTTGCACTTTTTGGATACTTTGTGCCTTATGTTCACTTGATGAAACATGTAAATGAA
AGATTTCAAGATGAAAAAAATAAAGAGGTTGTTCTCATGTGCATTGGCGTCACTTCAGGA
GTTGGACGACTGCTCTTTGGCCGGATTGCAGATTATGTGCCTGGTGTGAAGAAGGTTTAT
CTACAGGTACTCTCCTTTTTCTTCATTGGTCTGATGTCCATGATGATTCCTCTGTGTAGC
ATCTTTGGGGCCCTCATTGCTGTGTGCCTCATCATGGGTCTCTTCGATGGATGCTTCATT
TCCATTATGGCTCCCATAGCCTTTGAGTTAGTTGGTGCCCAGGATGTCTCCCAAGCAATT
GGATTTCTGCTCGGATTCATGTCTATACCCATGACTGTTGGCCCACCCATTGCAGGGTTA
CTTCGTGACAAACTGGGCTCCTATGATGTGGCATTCTACCTCGCTGGAGTCCCTCCCCTT
ATTGGAGGTGCTGTGCTTTGTTTTATCCCGTGGATCCATAGTAAGAAGCAAAGAGAGATC
AGTAAAACCACTGGAAAAGAAAAGATGGAGAAAATGTTGGAAAACCAGAACTCTCTGCTG
TCAAGTTCATCTGGAATGTTCAAGAAAGAATCTGACTCTATTATTTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AL360227

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_1_Locus:
6q21-q22

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
Not Available

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8881

# Macromolecular_Interacting_Partner_2_Name:
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

# Macromolecular_Interacting_Partner_2_Synonyms:
Amino acid transporter ATB0+; Solute carrier family 6 member 14

# Macromolecular_Interacting_Partner_2_Gene_Name:
SLC6A14

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Sodium and chloridedependent neutral and basic amino acid transporter B0+
MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVW
RFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGIT
MVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNK
GIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLA
LCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQ
SNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVF
AGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLG
LDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHF
CAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAI
FIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCC
RPASNWGPYLEQHRGERYKDMVDPKKEADHEIPTVSGSRKPE

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
642

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
72154

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
8.27

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  transporter activity
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_2_Signals:
1-469

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
45-65
72-92
110-130
235-255
261-281
315-335
348-368
399-419
450-477
480-500
528-548
563-583

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
5732680

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
S6A14_HUMAN (Q9UN76)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
SLC6A14

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
SLC6A14

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:11047

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1929 bp
ATGGACAAGTTGAAATGCCCGAGTTTCTTCAAGTGCAGGGAGAAGGAGAAAGTGTCGGCT
TCATCAGAGAATTTCCATGTTGGTGAAAATGATGAGAATCAGGACCGTGGTAACTGGTCC
AAAAAATCGGATTATCTTCTATCTATGATTGGATACGCAGTGGGATTAGGAAATGTGTGG
AGATTTCCATATCTGACCTACAGCAATGGTGGAGGCGCCTTCTTGATACCTTATGCAATT
ATGTTAGCATTGGCTGGTTTACCTTTGTTCTTTCTGGAGTGTTCACTGGGACAATTTGCT
AGCTTAGGTCCAGTTTCAGTTTGGAGGATTCTTCCATTGTTTCAAGGTGTGGGAATTACA
ATGGTCCTGATCTCCATTTTTGTGACAATCTATTACAATGTCATAATTGCCTATAGTCTT
TACTACATGTTTGCTTCTTTTCAAAGTGAACTACCATGGAAAAATTGTTCTTCGTGGTCA
GATAAAAACTGTAGCAGATCACCAATAGTAACTCACTGTAATGTGAGTACAGTGAATAAA
GGAATACAAGAGATCATCCAAATGAATAAAAGCTGGGTAGACATCAACAATTTTACCTGC
ATCAACGGCAGTGAAATTTATCAGCCAGGGCAGCTTCCCAGTGAACAATATTGGAATAAA
GTGGCGCTCCAACGGTCAAGTGGAATGAATGAGACTGGAGTAATTGTTTGGTATTTAGCA
CTTTGTCTTCTTCTGGCTTGGCTCATAGTTGGAGCAGCACTATTTAAAGGAATCAAATCG
TCTGGCAAGGTGGTATATTTTACAGCTCTTTTCCCCTATGTGGTCCTACTCATCCTGTTA
GTACGAGGTGCAACTCTGGAGGGTGCTTCAAAAGGCATTTCATACTATATTGGAGCCCAG
TCAAATTTTACAAAACTTAAGGAAGCTGAGGTATGGAAAGATGCTGCCACTCAGATATTT
TACTCCCTTTCAGTGGCTTGGGGTGGCTTAGTTGCTCTATCATCTTACAATAAGTTCAAA
AACAACTGCTTCTCTGATGCCATTGTGGTTTGTTTGACAAACTGTCTCACTAGCGTGTTT
GCTGGATTTGCTATTTTTTCTATATTGGGACACATGGCCCATATATCTGGAAAGGAAGTT
TCTCAAGTTGTAAAATCAGGTTTTGATTTGGCATTCATTGCCTATCCAGAGGCTCTAGCC
CAACTCCCAGGTGGTCCATTTTGGTCCATATTATTTTTTTTCATGCTTTTAACTTTGGGT
CTCGATTCTCAGTTTGCTTCGATTGAAACGATCACAACAACAATTCAAGATTTATTTCCC
AAAGTGATGAAGAAAATGAGGGTTCCCATAACTTTGGGCTGCTGCTTGGTTTTGTTTCTC
CTTGGTCTCGTCTGTGTGACTCAGGCTGGAATTTACTGGGTTCATCTGATTGACCACTTC
TGTGCTGGATGGGGCATTTTAATTGCAGCTATACTGGAGCTAGTTGGAATCATCTGGATT
TATGGAGGGAACAGATTCATTGAGGATACAGAAATGATGATTGGAGCAAAGAGGTGGATA
TTCTGGCTATGGTGGAGAGCTTGCTGGTTTGTAATTACGCCTATCCTTTTGATTGCAATA
TTTATCTGGTCATTGGTGCAATTTCATAGACCTAATTATGGCGCAATTCCATACCCTGAC
TGGGGAGTTGCTTTAGGCTGGTGTATGATTGTTTTCTGCATTATTTGGATACCAATTATG
GCTATCATAAAAATAATTCAGGCTAAAGGAAACATCTTTCAACGCCTTATAAGTTGCTGC
AGACCAGCTTCTAACTGGGGTCCATACCTGGAACAACATCGTGGGGAAAGATATAAAGAC
ATGGTAGATCCTAAAAAAGAGGCTGACCATGAAATACCTACTGTTAGTGGCAGCAGAAAA
CCGGAATGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AF151978

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_2_Locus:
Xq23-q24

# Macromolecular_Interacting_Partner_2_SNPs:
rs12720074; rs2011162; rs5905179; rs12710570; rs5905289; rs2011198; rs2312055; rs2032525; rs5905176; rs5905284; rs7059155; rs2071877; rs4824325; rs10217924; rs5905178; rs6608646; rs12392462; rs2312057; rs12391221; rs17242824; rs5905288; rs12559530; rs10218102; rs10521579; rs12710569; rs10521578; rs5905285; rs5952101; rs12720080; rs12720088; rs5952099; rs12720083; rs5905177; rs4824358; rs4824324; rs12720076; rs4824359; rs12720084; rs12720079; rs5952103; rs2312056; rs12720089; rs17095419; rs12393509; rs4824323; rs2312054; rs7052454; rs12710568; rs12720073; rs12834312; rs3788766; rs5905283; rs12720085; rs28523889; rs6608648; rs11350870; rs34685017; rs28699570; rs12720092; rs28628632; rs12720078; rs5952174; rs35604008; rs5952104; rs5905287; rs6608645; rs12388847; rs10629819; rs12720087; rs12720091; rs35269408; rs17308739; rs3043424; rs35542990; rs5952100; rs5952102; rs35201069; rs6651554; rs12720077; rs10218234; rs6608647; rs12858125; rs34117081; rs5952175; rs12720082; rs34490652; rs4068397; rs7066547; rs7054956; rs12832551; rs10218418; rs12720075; rs12720086; rs12720090; rs35315031; rs7062559; rs10218017; rs12390279; rs12833869; rs12835480; rs12839137; rs12844003; rs17308697; rs2103697; rs2301451; rs5952181; rs6520234; rs6608511; rs6608514; rs6608644; rs6608650

# Macromolecular_Interacting_Partner_2_General_References:
10446133

# Macromolecular_Interacting_Partner_2_References:
Not Available

End of HMDB00158

Beginning of HMDB00159
# Accession_No:
HMDB00159

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-19 12:14:41

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
L-Phenylalanine

# Description:
Phenylalanine is an essential amino acid and the precursor for the amino acid tyrosine. Like tyrosine, it is the precursor of catecholamines in the body (tyramine, dopamine, epinephrine and norepinephrine). The psychotropic drugs (mescaline, morphine, codeine, and papaverine) also have phenylalanine as a constituent. Phenylalanine is a precursor of the neurotransmitters called catecholamines, which are adrenalin-like substances. Phenylalanine is highly concentrated in the human brain and plasma. Normal metabolism of phenylalanine requires biopterin, iron, niacin, vitamin B6, copper and vitamin C. An average adult ingests 5 g of phenylalanine per day and may optimally need up to 8 g daily. Phenylalanine is highly concentrated in high protein foods, such as meat, cottage cheese and wheat germ. A new dietary source of phenylalanine is artificial sweeteners containing aspartame. Aspartame appears to be nutritious except in hot beverages; however, it should be avoided by phenylketonurics and pregnant women. Phenylketonurics, who have a genetic error of phenylalanine metabolism, have elevated serum plasma levels of phenylalanine up to 400 times normal. Mild phenylketonuria can be an unsuspected cause of hyperactivity, learning problems, and other developmental problems in children. Phenylalanine can be an effective pain reliever. Its use in premenstrual syndrome and Parkinson's may enhance the effects of acupuncture and electric transcutaneous nerve stimulation (TENS). Phenylalanine and tyrosine, like L-dopa, produce a catecholamine effect. Phenylalanine is better absorbed than tyrosine and may cause fewer headaches. Low phenylalanine diets have been prescribed for certain cancers with mixed results. Some tumors use more phenylalanine (particularly melatonin-producing tumors called melanoma). One strategy is to exclude this amino acid from the diet, i.e., a Phenylketonuria (PKU) diet (compliance is a difficult issue; it is hard to quantify and is under-researched). The other strategy is just to increase phenylalanine's competing amino acids, i.e., tryptophan, valine, isoleucine and leucine, but not tyrosine. (http://www.dcnutrition.com)

# Synonyms:
(-)-beta-Phenylalanine; (L)-Phenylalanine; (S)-(-)-Phenylalanine; (S)-2-Amino-3-phenylpropionate; (S)-2-Amino-3-phenylpropionic acid; (S)-2-amino-3-phenylpropanoate; (S)-2-amino-3-phenylpropanoic acid; (S)-Phenylalanine; (S)-alpha-Amino-benzenepropanoate; (S)-alpha-Amino-benzenepropanoic acid; (S)-alpha-Amino-beta-phenylpropionate; (S)-alpha-Amino-beta-phenylpropionic acid; (S)-alpha-Aminobenzenepropanoate; (S)-alpha-Aminobenzenepropanoic acid; (S)-alpha-Aminohydrocinnamate; (S)-alpha-Aminohydrocinnamic acid; 3-Phenyl-L-alanine; L-2-Amino-3-phenylpropionate; L-2-Amino-3-phenylpropionic acid; Phe; Phenylalamine; Phenylalanine; alpha-Aminohydrocinnamate; alpha-Aminohydrocinnamic acid; beta-Phenyl-L-alanine; beta-Phenyl-alpha-alanine; beta-Phenylalanine; phenyl-Alanine

# Chemical_IUPAC_Name:
2-amino-3-phenyl-propanoic acid

# Chemical_Formula:
C9H11NO2

# Chemical_Structure:
tbl_chemical:::HMDB00159_ZOOM.png:::119283225436854828

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00159_THUMB.png:::119283225277874971

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids; Nitrogenous Compounds

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid; aromatic compound; alpha-aminoacid

# Taxonomy_Biofunction:
Essential amino acids; Component of Aminoacyl-tRNA biosynthesis; Component of Novobiocin biosynthesis; Component of Phenylalanine metabolism; Component of Phenylalanine, tyrosine and tryptophan biosynthesis; Component of Tyrosine metabolism

# Taxonomy_Source:
Exogenous

# Molecular_Weight:
165.07898

# Molecular_Weight_Avg:
165.18913

# Smiles_String_isomeric:
N[C@@H](CC1=CC=CC=C1)C(O)=O

# Smiles_String_canonical:
NC(CC1=CC=CC=C1)C(O)=O

# KEGG_Compound_ID:
C00079

# BioCyc_ID:
PHE

# PubChem_CID:
6140

# PubChem_SID:
828600; 7847089; 819385; 3134198; 584667; 6436530; 828609; 8153851; 10531434; 826412; 8144203; 838754; 4252550; 11528323; 824902; 11457628; 833486; 822916; 828918; 824307; 830142; 3379; 11532528; 11459655; 841094; 830486; 149037; 7889851; 832928; 822460; 6436309; 822917

# OMIM_ID:
176730; 261630; 261640; 264070; 276600

# Metagene_ID:
Not Available

# BiGG_ID:
33775

# Wikipedia_ID:
L-Phenylalanine

# METLIN_ID:
28

# Ref_ID:
12101068; 15911239; 12297216; 14992292; 9849813; 455643; 822705; 12097436; 15750170; 11237944; 6696735; 12834252; 6198473

# ChEBI_ID:
17295

# CAS_Registry_Number:
63-91-2

# InChI:
InChI=1/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1

# Synthesis_Reference:
Synthesis of benzyl esters using benzyl bromide or iodide and its application to solid phase and conventional peptide synthesis; attempted sterical selection in solid phase synthesis.     Tilak, Manohar A.    Lilly Res. Lab.,  Eli Lilly and Co.,  Indianap

# Melting_Point:
283 oC

# Melting_Point_predicted:
105.2 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
26.9 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
4.14 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-1.38 [AVDEEF,A (1997)]

# LogP_predicted:
-1.35 [Predicted by ALOGPS]; -1.4 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::L-Phenylalanine.pdf:::1132562208421244195

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::L-Phenylalanine.mol:::1132723810968382482

# SDF_File_[Text]:
tbl_chemical:::HMDB00159.sdf:::119283224953340156

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00159.pdb:::119283225140953340

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041014_P00_01_HW_1DP_noesy.png:::1168900664462119047

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041014_P00_01_HW_1DP_presat.zip:::1177710593904376504

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041014_P00_01_HW_1DP_Assigned.png:::114667695279544863

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::041014_P00_01_HW_1DC_86.jpg:::114168460148073477

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041014_P00_01_HW_1DC_86.zip:::114168460145231891

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041014_P00_01_HW_1DC_86_Assigned.jpg:::114332855024120535

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041014_P00_01_HW_2DHSQC_294.jpg:::114608783922047106

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041014_P00_01_HW_2DHSQC_294.zip:::114608783925814407

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041014_P00_01_HW_2DHSQC_294_Assigned.jpg:::114608783950086423

# Predicted_H_NMR_Spectrum:
tbl_chemical:::L-Phenylalanine.gif:::1132732115453354734

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00159_peaks.txt:::1156309584447931148

# Predicted_C_NMR_Spectrum:
tbl_chemical:::L-Phenylalanine_C.gif:::1132737704114395161

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00159_peaks.txt:::1156310774172419719

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00159L.png:::1175552629292104; Medium Energy:tbl_ms:::HMDB00159M.png:::117555268225750221; High Energy:tbl_ms:::HMDB00159H.png:::117555271606125995

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000045.png:::116890824290697269

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000045.txt:::116890824290697104

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000045.png:::116890824267120687

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000045.txt:::116890824290661034

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Urine	4.605 (1.645-7.566)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Blood	57.0 (48.0-66.0)	umol/L	Adult:>18_yrs_old	Both	Normal	12297216
Blood	80.0 +/- 20.0	umol/L	Newborn:0-30_days_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	60.0 +/- 8.0	umol/L	Children:1-13_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	65.0 +/- 9.0	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Ge..992.
Blood	56.0 +/- 8.0	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	10.4 (7.58-13.2)	umol/L	Adult:>18_yrs_old	Both	Normal	12834252
Cerebrospinal_Fluid(CSF)	18.0 +/- 7.2	umol/L	Adult:>18_yrs_old	N/A	Normal	15911239
Cerebrospinal_Fluid(CSF)	12.5 +/- 2.9	umol/L	Adult:>18_yrs_old	N/A	Normal	6198473
Cerebrospinal_Fluid(CSF)	10.8 +/- 4.2	umol/L	Adult:>18_yrs_old	N/A	Normal	6198473
Cerebrospinal_Fluid(CSF)	43.0 +/- 34.0	uM	Adult:>18_yrs_old	Both	Normal	HMP Experimental
Cerebrospinal_Fluid(CSF)	6.5 +/- 1.2	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Saliva	>10	umol/L	Adult:>18_yrs_old	Both	Normal	12097436


# Concentration_[Abnormal]:
Blood	49.6 (47.1-52.1)	umol/L	Adult:>18_yrs_old	Both	Acute seizures	14992292
Blood	53.1 (50.8-55.4)	umol/L	Adult:>18_yrs_old	Both	Juvenile myoclonic epilepsy (JME)	14992292
Blood	60.0	umol/L	Adult:>18_yrs_old	Both	Diabetes	6696735
Blood	75.0 (67.0-83.0)	umol/L	Adult:>18_yrs_old	Both	Dengue	11237944
Blood	101.0 (97.0-105)	umol/L	Adult:>18_yrs_old	Both	Myocardial Infarction	822705
Blood	106.0	umol/L	Adult:>18_yrs_old	Both	Neonatal Maple syrup urine Disease (MSUD)	12101068
Blood	143.0 (128.0-158.0)	umol/L	Adult:>18_yrs_old	Both	Bacterial Infection	822705
Blood	171.0 (140.0-202.0)	umol/L	Adult:>18_yrs_old	Both	Viral Infection	822705
Blood	784.0	umol/L	Adult:>18_yrs_old	Both	Neonatal Phenylketonuria	12101068
Cerebrospinal_Fluid(CSF)	14.7 (11.6-17.8)	umol/L	Adult:>18_yrs_old	Both	Hypothyroidism	9849813
Cerebrospinal_Fluid(CSF)	18.6 +/- 5.2	umol/L	N/A	N/A	Leukemia with CNS disease	15911239
Cerebrospinal_Fluid(CSF)	16.4 +/- 6.3	umol/L	N/A	N/A	Leukemia	15911239
Cerebrospinal_Fluid(CSF)	14.7 +/- 3.1	umol/L	Adult:>18_yrs_old	N/A	hypothyroid patients	9849813
Cerebrospinal_Fluid(CSF)	14.7 +/- 3.1 	uM	Adult:>18_yrs_old	Both	Hypothyroid patients	9849813


# Associated_Disorders:
2-hydroxyglutaric aciduria; Acute seizures; Acute Tonic Clonic Seizures; Bacterial Infection; Dengue; Diabetes; hypothyroid patients; Hypothyroidism; Juvenile Myoclonic Epilepsy (JME); Leukemia; Leukemia with CNS disease; Myocardial Infarction; Neonatal Maple syrup urine Disease (MSUD); Neonatal Phenylketonuria; Neurodegeneration; Phenylalanine Hydroxylase Deficiency; Pterin-4-Alpha-Carbinolamine Dehydratase Deficiency; Tuberculous meningitis; Viral Infection

# Pathway_Names:
Prostaglandin and leukotriene metabolism;Alanine and aspartate metabolism

# Pathway_Images:
;Aspartate_and_Alanine_metabolism.jpg

# KEGG_Images:
map0059;map00252

# Pathway_Graphs:
;Aspartate_and_Alanine_metabolism_Graph.jpg

# Pathway_SBMLs:
;Aspartate_and_Alanine_metabolism.xml

# Metabolic_Enzyme_1_ID:
5506

# Metabolic_Enzyme_1_Name:
Phenylalanyl-tRNA synthetase alpha chain

# Metabolic_Enzyme_1_Synonyms:
Phenylalanine--tRNA ligase alpha chain; PheRS; CML33

# Metabolic_Enzyme_1_Gene_Name:
FARSA

# Metabolic_Enzyme_1_Protein_Sequence:
>PhenylalanyltRNA synthetase alpha chain
MADGQVAELLLRRLEASDGGLDSAELAAELGMEHQAVVGAVKSLQALGEVIEAELRSTKH
WELTAEGEEIAREGSHEARVFRSIPPEGLAQSELMRLPSGKVGFSKAMSNKWIRVDKSAA
DGPRVFRVVDSMEDEVQRRLQLVRGGQAEKLGEKERSELRKRKLLAEVTLKTYWVSKGSA
FSTSISKQETELSPEMISSGSWRDRPFKPYNFLAHGVLPDSGHLHPLLKVRSQFRQIFLE
MGFTEMPTDNFIESSFWNFDALFQPQQHPARDQHDTFFLRDPAEALQLPMDYVQRVKRTH
SQGGYGSQGYKYNWKLDEARKNLLRTHTTSASARALYRLAQKKPFTPVKYFSIDRVFRNE
TLDATHLAEFHQIEGVVADHGLTLGHLMGVLREFFTKLGITQLRFKPAYNPYTEPSMEVF
SYHQGLKKWVEVGNSGVFRPEMLLPMGLPENVSVIAWGLSLERPTMIKYGINNIRELVGH
KVNLQMVYDSPLCRLDAEPRPPPTQEAA

# Metabolic_Enzyme_1_Number_of_Residues:
508

# Metabolic_Enzyme_1_Molecular_Weight:
57564

# Metabolic_Enzyme_1_Theoretical_pI:
7.96

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  phenylalanine-tRNA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  phenylalanyl-tRNA aminoacylation
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_1_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_1_Specific_Function:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

# Metabolic_Enzyme_1_Pathway:
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_1_Reaction:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF08279:HTH_11;
PF01409:tRNA-synt_2d

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 6.1.1.20

# Metabolic_Enzyme_1_GenBank_ID_Protein:
2102679

# Metabolic_Enzyme_1_SwissProt_ID:
SYFA_HUMAN (Q9Y285)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
FARSA

# Metabolic_Enzyme_1_Geneatlas_id:
FARSA

# Metabolic_Enzyme_1_hgnc_id:
HGNC:3592

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1527 bp
ATGGCGGATGGTCAGGTGGCGGAACTGCTGCTCCGGCGGCTGGAGGCGTCTGATGGCGGC
CTGGACAGCGCCGAGTTGGCGGCTGAGCTGGGCATGGAGCACCAGGCGGTGGTGGGCGCC
GTGAAGAGCCTTCAGGCGCTGGGCGAGGTCATCGAGGCTGAACTTCGGTCCACCAAGCAC
TGGGAGCTTACTGCGGAGGGCGAGGAGATTGCCCGGGAGGGCAGCCATGAGGCCCGTGTG
TTTCGAAGCATTCCCCCAGAGGGCCTGGCCCAGAGCGAGCTTATGCGACTGCCCAGTGGC
AAAGTGGGCTTCAGCAAGGCCATGTCCAACAAGTGGATTCGGGTGGACAAGAGTGCGGCT
GACGGGCCCCGGGTGTTCCGAGTGGTGGACAGCATGGAGGATGAGGTGCAGCGGCGGCTC
CAGCTGGTCCGGGGGGGACAGGCTGAGAAGCTGGGGGAGAAGGAGAGGAGCGAGCTGAGG
AAGAGGAAGCTGTTGGCTGAAGTGACTCTGAAGACCTACTGGGTGAGCAAAGGCAGTGCC
TTTAGTACCAGCATCTCCAAGCAAGAGACAGAGCTGAGCCCAGAGATGATCTCCAGTGGC
TCTTGGCGGGACCGGCCCTTCAAGCCCTACAACTTCTTGGCCCACGGTGTCCTCCCCGAC
AGCGGCCACCTTCACCCGCTGCTCAAGGTCCGCTCCCAGTTCCGACAGATCTTCCTGGAG
ATGGGGTTCACCGAGATGCCGACTGATAACTTCATTGAGAGCTCCTTCTGGAACTTTGAC
GCCCTCTTCCAGCCCCAGCAGCACCCAGCCCGTGACCAGCACGACACCTTCTTCCTTCGA
GATCCAGCGGAGGCCCTGCAGCTCCCAATGGACTATGTCCAGCGGGTCAAGCGGACCCAC
TCTCAGGGCGGCTACGGCTCACAGGGGTACAAGTATAACTGGAAGCTGGACGAGGCCCGG
AAAAACCTACTGCGAACCCACACCACATCAGCCAGCGCCCGTGCGCTCTACCGCCTTGCC
CAGAAGAAGCCCTTCACTCCGGTCAAGTACTTCTCCATCGACCGCGTATTCCGGAATGAG
ACCCTGGACGCCACGCACCTGGCTGAGTTCCACCAGATCGAGGGCGTGGTGGCGGATCAT
GGTCTCACCTTGGGCCACCTCATGGGCGTTCTGCGGGAGTTCTTCACCAAGCTGGGTATC
ACGCAACTCCGCTTCAAGCCAGCCTACAACCCATACACAGAGCCCAGCATGGAGGTGTTC
AGCTACCACCAAGGCCTGAAGAAGTGGGTGGAGGTCGGAAACTCGGGGGTCTTCCGTCCA
GAGATGCTGCTGCCCATGGGGCTTCCCGAGAACGTGTCGGTCATTGCCTGGGGCCTCTCC
CTGGAGCGCCCAACGATGATCAAATATGGCATCAACAATATCCGGGAGCTGGTGGGCCAC
AAGGTGAACCTGCAGATGGTGTATGACAGTCCCCTGTGCCGCCTGGATGCCGAGCCGAGG
CCCCCTCCCACACAGGAGGCTGCGTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U07424

# Metabolic_Enzyme_1_Chromosome_Location:
Not Available

# Metabolic_Enzyme_1_Locus:
Not Available

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
9177188; 10049785; 12665801

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5507

# Metabolic_Enzyme_2_Name:
Phenylalanyl-tRNA synthetase, mitochondrial precursor

# Metabolic_Enzyme_2_Synonyms:
Phenylalanine--tRNA ligase; PheRS

# Metabolic_Enzyme_2_Gene_Name:
FARS2

# Metabolic_Enzyme_2_Protein_Sequence:
>PhenylalanyltRNA synthetase, mitochondrial precursor
MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQ
DDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVV
TTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRR
DQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVE
FDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVN
SAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKY
PAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRH
MERTLSQREVRHIHQALQEAAVQLLGVEGRF

# Metabolic_Enzyme_2_Number_of_Residues:
451

# Metabolic_Enzyme_2_Molecular_Weight:
52357

# Metabolic_Enzyme_2_Theoretical_pI:
7.48

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  phenylalanine-tRNA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  phenylalanyl-tRNA aminoacylation
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_2_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_2_Specific_Function:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

# Metabolic_Enzyme_2_Pathway:
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_2_Reaction:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF03147:FDX-ACB;
PF01409:tRNA-synt_2d

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 6.1.1.20

# Metabolic_Enzyme_2_GenBank_ID_Protein:
3983103

# Metabolic_Enzyme_2_SwissProt_ID:
SYFM_HUMAN (O95363)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
FARS2

# Metabolic_Enzyme_2_Geneatlas_id:
FARS2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:21062

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Mitochondrion; mitochondrial matrix (Potential)

# Metabolic_Enzyme_2_Gene_Sequence:
>1356 bp
ATGGTGGGCTCAGCTCTCAGGAGAGGTGCCCATGCATATGTCTACCTGGTGAGTAAGGCC
AGTCACATCTCCAGAGGCCATCAGCACCAGGCCTGGGGATCGAGGCCTCCTGCAGCAGAG
TGTGCCACCCAAAGAGCTCCAGGCAGTGTGGTGGAGCTGCTGGGCAAATCCTACCCTCAG
GACGACCACAGCAACCTCACCCGGAAGGTCCTCACCAGAGTTGGCAGGAACCTGCACAAC
CAGCAGCATCACCCTCTGTGGCTGATCAAGGAGAGGGTGAAGGAGCACTTCTACAAGCAG
TATGTGGGCCGCTTTGGGACCCCGTTGTTCTCGGTCTACGACAACCTTTCTCCAGTGGTC
ACGACCTGGCAGAACTTTGACAGCCTGCTCATCCCAGCTGATCACCCCAGCAGGAAGAAG
GGGGACAACTATTACCTGAATCGGACTCACATGCTGAGAGCGCACACGTCTGCACACCAG
TGGGACTTGCTGCACGCGGGACTGGATGCCTTCCTGGTGGTGGGTGATGTCTACAGGCGT
GACCAGATCGACTCCCAGCACTACCCTATTTTCCACCAGCTGGAGGCCGTGCGGCTCTTC
TCCAAGCATGAGTTATTTGCTGGTATAAAGGATGGAGAAAGCCTGCAGCTCTTTGAACAA
AGTTCTCGCTCTGCGCATAAACAAGAGACACACACCATGGAGGCCGTGAAGCTTGTAGAG
TTTGATCTTAAGCAAACGCTTACCAGGCTCATGGCACATCTTTTTGGAGATGAGCTGGAG
ATAAGATGGGTAGACTGCTACTTCCCTTTTACACATCCTTCCTTTGAGATGGAGATCAAC
TTTCATGGAGAATGGCTGGAAGTTCTTGGCTGCGGGGTGATGGAACAACAACTGGTCAAT
TCAGCTGGTGCTCAAGACCGAATCGGCTGGGCTTTTGGCCTAGGATTAGAAAGGCTAGCC
ATGATCCTCTACGACATCCCTGATATCCGTCTCTTCTGGTGTGAGGACGAGCGCTTCCTG
AAGCAGTTCTGTGTATCCAACATTAATCAGAAGGTGAAGTTTCAGCCTCTTAGCAAATAT
CCGGCTGTGATCAATGATATTTCATTCTGGTTGCCCTCTGAGAATTACGCAGAAAATGAT
TTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATCTCATAGAC
AAGTTTGTACATCCAAAGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCAC
ATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCCTTGCAGGAGGCT
GCAGTCCAGCTGTTGGGTGTGGAGGGCAGGTTCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF097441

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_2_Locus:
6p25.1

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
10329163; 14574404

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5508

# Metabolic_Enzyme_3_Name:
Thyroid peroxidase precursor

# Metabolic_Enzyme_3_Synonyms:
TPO

# Metabolic_Enzyme_3_Gene_Name:
TPO

# Metabolic_Enzyme_3_Protein_Sequence:
>Thyroid peroxidase precursor
MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR
NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS
EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV
YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD
IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD
QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG
RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA
LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT
VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIR
GLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGL
PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ
MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES
CDSIPGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL
TCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD
SGRLPRATWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ
AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL

# Metabolic_Enzyme_3_Number_of_Residues:
933

# Metabolic_Enzyme_3_Molecular_Weight:
102932

# Metabolic_Enzyme_3_Theoretical_pI:
6.75

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4)

# Metabolic_Enzyme_3_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_3_Reaction:
iodide + H2O2 = iodine + 2 H2O

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF03098:An_peroxidase;
PF07645:EGF_CA;
PF00084:Sushi

# Metabolic_Enzyme_3_Signals:
1-14

# Metabolic_Enzyme_3_Transmembrane_Regions:
847-871

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.11.1.8

# Metabolic_Enzyme_3_GenBank_ID_Protein:
339867

# Metabolic_Enzyme_3_SwissProt_ID:
PERT_HUMAN (P07202)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
TPO

# Metabolic_Enzyme_3_Geneatlas_id:
TPO

# Metabolic_Enzyme_3_hgnc_id:
HGNC:12015

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Metabolic_Enzyme_3_Gene_Sequence:
>2802 bp
ATGAGAGCGCTCGCTGTGCTGTCTGTCACGCTGGTTATGGCCTGCACAGAAGCCTTCTTC
CCCTTCATCTCGAGAGGGAAAGAACTCCTTTGGGGAAAGCCTGAGGAGTCTCGTGTCTCT
AGCGTCTTGGAGGAAAGCAAGCGCCTGGTGGACACCGCCATGTACGCCACGATGCAGAGA
AACCTCAAGAAAAGAGGAATCCTTTCTCCAGCTCAGCTTCTGTCTTTTTCCAAACTTCCT
GAGCCAACAAGCGGAGTGATTGCCCGAGCAGCAGAGATAATGGAAACATCAATACAAGCG
ATGAAAAGAAAAGTCAACCTGAAAACTCAACAATCACAGCATCCAACGGATGCTTTATCA
GAAGATCTGCTGAGCATCATTGCAAACATGTCTGGATGTCTCCCTTACATGCTGCCCCCA
AAATGCCCAAACACTTGCCTGGCGAACAAATACAGGCCCATCACAGGAGCTTGCAACAAC
AGAGACCACCCCAGATGGGGCGCCTCCAACACGGCCCTGGCACGATGGCTCCCTCCAGTC
TATGAGGACGGCTTCAGTCAGCCCCGAGGCTGGAACCCCGGCTTCTTGTACAACGGGTTC
CCACTGCCCCCGGTCCGGGAGGTGACAAGACATGTCATTCAAGTTTCAAATGAGGTTGTC
ACAGATGATGACCGCTATTCTGACCTCCTGATGGCATGGGGACAATACATCGACCACGAC
ATCGCGTTCACACCACAGAGCACCAGCAAAGCTGCCTTCGGGGGAGGGGCTGACTGCCAG
ATGACTTGTGAGAACCAAAACCCATGTTTTCCCATACAACTCCCGGAGGAGGCCCGGCCG
GCCGCGGGCACCGCCTGTCTGCCCTTCTACCGCTCTTCGGCCGCCTGCGGCACCGGGGAC
CAAGGCGCGCTCTTTGGGAACCTGTCCACGGCCAACCCGCGGCAGCAGATGAACGGGTTG
ACCTCGTTCCTGGACGCGTCCACCGTGTATGGCAGCTCCCCGGCCCTAGAGAGGCAGCTG
CGGAACTGGACCAGTGCCGAAGGGCTGCTCCGCGTCCACGCGCGCCTCCGGGACTCCGGC
CGCGCCTACCTGCCCTTCGTGCCGCCACGGCGGCCTGCGGCCTGTGCGCCCGAGCCCGGC
ATCCCCGGAGAGACCCGCGGGCCCTGCTTCCTGGCCGGAGACGGCCGCGCCAGCGAGGTC
CCCTCCCTGACGGCACTGCACACGCTGTGGCTGCGCGAGCACAACCGCCTGGCCGCGGCG
CTCAAGGCCCTCAATGCGCACTGGAGCGCGGACGCCGTGTACCAGGAGGCGCGCAAGGTC
GTGGGCGCTCTGCACCAGATCATCACCCTGAGGGATTACATCCCCAGGATCCTGGGACCC
GAGGCCTTCCAGCAGTACGTGGGTCCCTATGAAGGCTATGACTCCACCGCCAACCCCACT
GTGTCCAACGTGTTCTCCACAGCCGCCTTCCGCTTCGGCCATGCCACGATCCACCCGCTG
GTGAGGAGGCTGGACGCCAGCTTCCAGGAGCACCCCGACCTGCCCGGGCTGTGGCTGCAC
CAGGCTTTCTTCAGCCCATGGACATTACTCCGTGGAGGTGGTTTGGACCCACTAATACGA
GGCCTTCTTGCAAGACCAGCCAAACTGCAGGTGCAGGATCAGCTGATGAACGAGGAGCTG
ACGGAAAGGCTCTTTGTGCTGTCCAATTCCAGCACCTTGGATCTGGCGTCCATCAACCTG
CAGAGGGGCCGGGACCACGGGCTGCCAGGTTACAATGAGTGGAGGGAGTTCTGCGGCCTG
CCTCGCCTGGAGACCCCCGCTGACCTGAGCACAGCCATCGCCAGCAGGAGCGTGGCCGAC
AAGATCCTGGACTTGTACAAGCATCCTGACAACATCGATGTCTGGCTGGGAGGCTTAGCT
GAAAACTTCCTCCCCAGGGCTCGGACAGGGCCCCTGTTTGCCTGTCTCATTGGGAAGCAG
ATGAAGGCTCTGCGGGATGGTGACTGGTTTTGGTGGGAGAACAGCCACGTCTTCACGGAT
GCACAGAGGCGTGAGCTGGAGAAGCACTCCCTGTCTCGGGTCATCTGTGACAACACTGGC
CTCACCAGGGTGCCCATGGATGCCTTCCAAGTCGGCAAATTCCCTGAAGACTTTGAGTCT
TGTGACAGCATCCCTGGCATGAACCTGGAGGCCTGGAGGGAAACCTTTCCTCAAGACGAC
AAGTGTGGCTTCCCAGAGAGCGTGGAGAATGGGGACTTTGTGCACTGTGAGGAGTCTGGG
AGGCGCGTGCTGGTGTATTCCTGCCGGCACGGGTATGAGCTCCAAGGCCGGGAGCAGCTC
ACTTGCACCCAGGAAGGATGGGATTTCCAGCCTCCCCTCTGCAAAGATGTGAACGAGTGT
GCAGACGGTGCCCACCCCCCCTGCCACGCCTCTGCGAGGTGCAGAAACACCAAAGGCGGC
TTCCAGTGTCTCTGCGCGGACCCCTACGAGTTAGGAGACGATGGGAGAACCTGCGTAGAC
TCCGGGAGGCTCCCTCGGGCGACTTGGATCTCCATGTCGCTGGCTGCTCTGCTGATCGGA
GGCTTCGCAGGTCTCACCTCGACGGTGATTTGCAGGTGGACACGCACTGGCACTAAATCC
ACACTGCCCATCTCGGAGACAGGCGGAGGAACTCCCGAGCTGAGATGCGGAAAGCACCAG
GCCGTAGGGACCTCACCGCAGCGGGCCGCAGCTCAGGACTCGGAGCAGGAGAGTGCTGGG
ATGGAAGGCCGGGATACTCACAGGCTGCCGAGAGCCCTCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
J02969

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_3_Locus:
2p25

# Metabolic_Enzyme_3_SNPs:
rs2175977; rs13431173; rs732609; rs4927611; rs1126799; rs10189135; rs1042589; rs2280132; rs28915688; rs28991293; rs28913014; rs732608; rs13429240; rs17091745; rs28915689; rs28909989; rs28910597; rs9678281; rs17415659; rs2071403; rs9326166; rs9326167; rs17091628; rs28909986; rs28909987; rs2009364; rs1464083; rs1514686; rs1464086; rs2048726; rs2048722; rs961028; rs1965406; rs2048721; rs1514682; rs1877854; rs6715129; rs7602540; rs949835; rs938330; rs9679017; rs6706775; rs9751670; rs10198697; rs1399390; rs11211650; rs2070878; rs13424221; rs1399387; rs10172186; rs10206727; rs11694817; rs3755554; rs6588672; rs10165715; rs10208730; rs9326170; rs4927624; rs4927612; rs2070879; rs4278970; rs4927619; rs13430369; rs13413321; rs2276702; rs6716111; rs2175978; rs10204647; rs1877855; rs7583792; rs6717381; rs4927615; rs2280129; rs7598233; rs6711545; rs11891272; rs13425669; rs11886972; rs7596885; rs6716250; rs11211651; rs6732480; rs9679267; rs6747390; rs6588665; rs867983; rs9326169; rs11896517; rs1464085; rs11888851; rs6708496; rs7602332; rs10170919; rs2361754; rs1464084; rs6714887; rs6759960; rs1514688; rs2090154; rs1913584; rs6708273; rs10204515; rs3755555; rs11888196; rs10201842; rs6711901; rs938327; rs2138018; rs1567918; rs6760043; rs10171105; rs2138019; rs4927610; rs6752121; rs10205811; rs11211654; rs6740728; rs10189329; rs6727192; rs2070881; rs1965405; rs6588664; rs1473936; rs10177597; rs11897437; rs1967512; rs2885361; rs2361748; rs4927631; rs1514687; rs11690515; rs11904276; rs950675; rs6588669; rs10169429; rs4927621; rs11896057; rs6588674; rs11691841; rs6588673; rs10197874; rs9678469; rs9751407; rs4927608; rs2014911; rs6723319; rs1399389; rs4927580; rs10205420; rs11897713; rs2885362; rs11211653; rs2070882; rs9750182; rs6588663; rs12615819; rs4927578; rs10174000; rs13386909; rs6754104; rs17732233; rs6718027; rs11891867; rs13393765; rs11211649; rs10193983; rs13398180; rs4927574; rs11687944; rs9973690; rs2280131; rs7574221; rs12465127; rs11675388; rs10200413; rs10167570; rs13412229; rs6588676; rs13429459; rs3755549; rs12328748; rs13427125; rs28361468; rs9326171; rs3834179; rs3755548; rs4359704; rs2361767; rs10188260; rs11694726; rs17091772; rs10165832; rs949834; rs11674560; rs4927581; rs7424680; rs3796122; rs13412980; rs17731349; rs9677050; rs4927606; rs13431646; rs13415674; rs949833; rs4927593; rs4927585; rs4600709; rs1514685; rs4328675; rs4927591; rs17731324; rs4425120; rs11899801; rs10495482; rs4927589; rs2070877; rs4927632; rs2070880; rs2048727; rs2276701; rs12619427; rs13431898; rs3755550; rs10519477; rs12472829; rs6588671; rs10170270; rs13405352; rs1976692; rs10189437; rs3772076; rs3772075; rs6588667; rs11683914; rs11211647; rs4481033; rs13431282; rs2276704; rs11691963; rs11891228; rs10166929; rs2280128; rs10190245; rs6588675; rs4927590; rs13414566; rs2361750; rs10196514; rs1514684; rs4592894; rs3772074; rs4927579; rs28663288; rs6588670; rs11211652; rs7355479; rs11692536; rs13409391; rs12470856; rs3755551; rs10181072; rs11691145; rs13405477; rs17091682; rs11682961; rs6712430; rs11897718; rs10194040; rs10207656; rs11681087; rs11211646; rs17091633; rs13400150; rs4927575; rs949832; rs1969248; rs17091667; rs13418264; rs7564759; rs1818525; rs13392535; rs11689536; rs11896906; rs17091737; rs3755553; rs3755552; rs12478431; rs4927617; rs6751783; rs9326172; rs1514683; rs11887707; rs938328; rs6588678; rs17091744; rs2048724; rs11211655; rs2007268; rs28913037; rs28909998; rs13409815; rs10890518; rs28910600; rs28912368; rs11886764; rs28913007; rs28910585; rs28912975; rs28910579; rs7607582; rs28912989; rs9326168; rs28911496; rs28991288; rs28913033; rs28910603; rs28910595; rs28915678; rs28909396; rs28909371; rs9798488; rs28912994; rs11904640; rs12616671; rs28911471; rs28909384; rs28913016; rs28991294; rs28912972; rs13016763; rs12471358; rs28991276; rs28909999; rs13422969; rs11675177; rs28911488; rs28909393; rs28915676; rs28912991; rs4927607; rs28910607; rs6588668; rs4927614; rs12471599; rs11685779; rs28910000; rs28913029; rs28909401; rs28910568; rs28991269; rs28912974; rs11686432; rs11674407; rs28910591; rs28991283; rs4927586; rs28913003; rs2361744; rs2138020; rs4927592; rs28991290; rs28915672; rs28909379; rs28909400; rs29001651; rs28911495; rs28911485; rs28909994; rs28909372; rs28911492; rs4927594; rs28910575; rs10181280; rs28911481; rs11695695; rs28910578; rs28913271; rs28909415; rs4927622; rs28909397; rs28913022; rs11678545; rs28909390; rs28911170; rs28910007; rs11899018; rs28915677; rs28910594; rs28911470; rs9677934; rs12328533; rs28915670; rs28991273; rs17732056; rs28911475; rs28913008; rs9677308; rs28910586; rs28910606; rs28909380; rs28912992; rs28909402; rs28910574; rs9678767; rs6711500; rs28911487; rs28913023; rs28915684; rs4927577; rs13391992; rs28909411; rs11211648; rs11685540; rs28913275; rs28912969; rs28913030; rs28915673; rs28991277; rs28909407; rs28909387; rs28909993; rs28911480; rs4567992; rs28911171; rs13394978; rs28911493; rs28913041; rs11885587; rs28910583; rs28913270; rs28912999; rs2138017; rs10197546; rs28991289; rs4927628; rs9678341; rs28913004; rs28911478; rs28910013; rs28912996; rs10205550; rs28910599; rs13391557; rs28909391; rs28915680; rs4927582; rs4927625; rs17731501; rs13409953; rs11676827; rs13418570; rs11683140; rs9677680; rs13394194; rs28913013; rs28912985; rs11889947; rs28912981; rs1113829; rs4927584; rs10207591; rs28912980; rs2048725; rs28913274; rs4927613; rs28991274; rs28913011; rs28910005; rs28910002; rs9678972; rs13016765; rs17091706; rs28909403; rs28991281; rs28910605; rs28909383; rs28913273; rs28913017; rs28913024; rs13410529; rs7591179; rs28910611; rs28909394; rs28915685; rs28910580; rs11899974; rs12468041; rs11690402; rs28909368; rs28915674; rs28909373; rs28912998; rs28913009; rs28913039; rs28911175; rs28913035; rs17091666; rs28911490; rs28991270; rs28910577; rs28909992; rs28910001; rs28911172; rs28912984; rs4927588; rs28910571; rs28910010; rs4425119; rs28909389; rs28913028; rs13399844; rs4314036; rs12621034; rs4927609; rs28915668; rs4645041; rs13426289; rs4927616; rs28910609; rs28912988; rs28913040; rs11687912; rs28991285; rs28910573; rs28910584; rs28913020; rs28911476; rs28910602; rs28913005; rs6588666; rs11676091; rs28913031; rs10204402; rs28913001; rs28909668; rs28911483; rs28911473; rs28909374; rs28911468; rs13430623; rs28909386; rs28991271; rs28909382; rs28913021; rs12328004; rs28910576; rs11695385; rs1965407; rs28910601; rs28909990; rs4629198; rs28912993; rs10193135; rs28913010; rs28911173; rs28912977; rs7568087; rs28910014; rs1828865; rs12718450; rs28911491; rs11674711; rs28911168; rs4927587; rs28909991; rs28910581; rs28910610; rs28909395; rs4927583; rs28913018; rs1567919; rs28912971; rs28913036; rs28991275; rs28913042; rs28915675; rs28991287; rs28910588; rs28991278; rs961029; rs28912990; rs28913019; rs1567917; rs28910608; rs28909408; rs28912987; rs28909375; rs28915669; rs28912970; rs28909385; rs7597945; rs28991272; rs28913269; rs11676046; rs28909392; rs28909414; rs28909388; rs28910011; rs28912983; rs12105374; rs28991279; rs4404322; rs28915671; rs28911482; rs12613496; rs13431561; rs4927630; rs28913272; rs28912973; rs28911469; rs28911472; rs28909399; rs28913006; rs28911494; rs28910572; rs11690812; rs13415386; rs2071399; rs2280126; rs2298876; rs2071402; rs2071401; rs4927604; rs2280127; rs2071400; rs28991568; rs28915690; rs28909983; rs2298875; rs28910612; rs28991292; rs17855780; rs28915687; rs28910598; rs3732349; rs35105246; rs13407655; rs28909988; rs28915683; rs10536458; rs35505969; rs12474694; rs6755275; rs10180652; rs12993998; rs33961599; rs28909381; rs28360867; rs4927627; rs11681539; rs13410524; rs13383329; rs28912968; rs13415459; rs9973956; rs35756267; rs28909376; rs35523187; rs2048723; rs28630635; rs13031189; rs28911174; rs28633865; rs28909410; rs10629723; rs28909378; rs11677995; rs34132009; rs13413324; rs28911474; rs28910590; rs12994019; rs34920078; rs13000154; rs13000160; rs35605249; rs10166153; rs35043612; rs10666298; rs13026152; rs2885358; rs33990262; rs28910604; rs28910582; rs11688703; rs34374057; rs28912978; rs10176490; rs28915686; rs34413546; rs28632119; rs35225495; rs13430142; rs35431867; rs12987712; rs28460424; rs35944967; rs10184056; rs35732856; rs35531860; rs36119335; rs13396955; rs28909406; rs13020227; rs10203030; rs12612745; rs11689344; rs28912982; rs10206512; rs28912986; rs7369446; rs11686894; rs28909997; rs12986996; rs11691839; rs13035669; rs28580848; rs13006856; rs13385085; rs13415301; rs3831487; rs10190227; rs11686114; rs28912995; rs12616672; rs11412726; rs28915679; rs35725026; rs28672357; rs35893094; rs28910012; rs12476324; rs10608158; rs28874626; rs28909369; rs28464331; rs28445930; rs12986956; rs28913038; rs28991280; rs34191654; rs28665837; rs12478638; rs1399391; rs11688366; rs13006647; rs28910003; rs13036149; rs6705010; rs28671559; rs35708755; rs2280130; rs13410383; rs13393048; rs28909412; rs13430024; rs28912979; rs13382606; rs10193732; rs10573336; rs34043302; rs9677153; rs35874586; rs13382789; rs28437604; rs11678127; rs13430374; rs36220342; rs13397445; rs35553172; rs34128932; rs28911484; rs28991284; rs13431558; rs11687959; rs12105080; rs28991268; rs13027675; rs13000139; rs28651176; rs11687787; rs35908928; rs10208039; rs28913000; rs28729219; rs28566655; rs10194736; rs13026377; rs10666299; rs13420584; rs28910006; rs9677433; rs13424741; rs10184419; rs34359520; rs35103896; rs34099200; rs28909996; rs28433376; rs11904785; rs5828821; rs28909377; rs12612565; rs11272722; rs13392954; rs35752553; rs35208164; rs28378083; rs34080455; rs28913012; rs28636451; rs11272011; rs12992674; rs11412725; rs28435455; rs35700910; rs35500489; rs35104320; rs35727441; rs34796953; rs7369268; rs7368786; rs28591627; rs28420122; rs35584537; rs11691743; rs35123035; rs34032155; rs28910008; rs4927605; rs2885360; rs3036100; rs28910587; rs34933514; rs28911486; rs2090153; rs34445751; rs11404899; rs35682038; rs4927629; rs35388919; rs34044289; rs11898092; rs12475212; rs28683616; rs28409666; rs11893496; rs3036105; rs2175979; rs28909413; rs35858346; rs28913268; rs34602774; rs34131144; rs3036079; rs4927620; rs28682482; rs13409826; rs35614838; rs34480829; rs12992385; rs28911479; rs28913025; rs35623494; rs28909995; rs36175402; rs13418129; rs13406835; rs34046827; rs28915681; rs11687965; rs35008230; rs13006236; rs5828824; rs34879368; rs28911169; rs9973952; rs13417585; rs28912976; rs13010957; rs9973955; rs13020631; rs35943116; rs28909398; rs13423107; rs28461932; rs13012709; rs28910593; rs13423282; rs4927596; rs13014527; rs10191653; rs34064729; rs11673992; rs9750163; rs9677530; rs28909404; rs4927626; rs13404230; rs7583423; rs28910569; rs35290486; rs2361747; rs13006630; rs10181396; rs9973911; rs28991282; rs28915682; rs28911489; rs28437028; rs5828823; rs28681289; rs13404488; rs28912997; rs10170298; rs28913015; rs13014542; rs13385523; rs13027419; rs11689386; rs35839340; rs13036125; rs28910009; rs34541512; rs34790485; rs28677046; rs28910596; rs34413535; rs34531889; rs28909370; rs11687810; rs9679416; rs34950864; rs2203399; rs34932469; rs10523977; rs11673953; rs34234148; rs12986550; rs28620935; rs2090152; rs13026363; rs28909409; rs28913026; rs28489465; rs35201002; rs13403910; rs34521796; rs28913027; rs11887001; rs35836927; rs28432167; rs10197112; rs28910592; rs28910570; rs7579188; rs34088587; rs11371261; rs13402950; rs12476325; rs12151527; rs28913002; rs4927595; rs10634971; rs35224341; rs35631326; rs13403265; rs2885359; rs28911477; rs13000185; rs28991286; rs28910004; rs11673934; rs28909405; rs13031191; rs28913032; rs28991291; rs28909985; rs28991569; rs35374888; rs10179394; rs28909984; rs13407296; rs10192959; rs10202105; rs10206900; rs10890517; rs11211645; rs11675342; rs11675434; rs11678852; rs11681698; rs11682968; rs11685159; rs11686524; rs11686775; rs11694732; rs12469603; rs12471910; rs12990372; rs13017252; rs13390616; rs13400534; rs13407974; rs13413096; rs13413987; rs13414537; rs13426896; rs1567920; rs17091606; rs17091611; rs17091616; rs17786733; rs1828864; rs2298873; rs2298874; rs35743195; rs6605278; rs6705087; rs9677074

# Metabolic_Enzyme_3_General_References:
3475693; 3453124; 2548579; 2308857; 12454013; 3654979; 2383265; 7550241; 9024270; 10468986; 10084596; 9924196; 11061528; 11415848; 11916616; 12213873; 11874711; 12938097

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5509

# Metabolic_Enzyme_4_Name:
Tyrosine aminotransferase

# Metabolic_Enzyme_4_Synonyms:
L-tyrosine:2-oxoglutarate aminotransferase; TAT

# Metabolic_Enzyme_4_Gene_Name:
TAT

# Metabolic_Enzyme_4_Protein_Sequence:
>Tyrosine aminotransferase
MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAKKTFNPIRAIV
DNMKVKPNPNKTMISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGFLSSRE
EIASYYHCPEAPLEAKDVILTSGCSQAIDLCLAVLANPGQNILVPRPGFSLYKTLAESMG
IEVKLYNLLPEKSWEIDLKQLEYLIDEKTACLIVNNPSNPCGSVFSKRHLQKILAVAARQ
CVPILADEIYGDMVFSDCKYEPLATLSTDVPILSCGGLAKRWLVPGWRLGWILIHDRRDI
FGNEIRDGLVKLSQRILGPCTIVQGALKSILCRTPGEFYHNTLSFLKSNADLCYGALAAI
PGLRPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLVAEQSVHCLPATCFEYPNFIRVVI
TVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK

# Metabolic_Enzyme_4_Number_of_Residues:
454

# Metabolic_Enzyme_4_Molecular_Weight:
50400

# Metabolic_Enzyme_4_Theoretical_pI:
6.24

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  transaminase activity
Function:  tyrosine transaminase activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-sulfur lyase activity
Function:  1-aminocyclopropane-1-carboxylate synthase activity
 ||
>>>
Process:  aromatic amino acid family metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  amino acid catabolism
Process:  aromatic amino acid family catabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
L-tyrosine + 2-oxoglutarate = 4- hydroxyphenylpyruvate + L-glutamate

# Metabolic_Enzyme_4_Pathway:
map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00401  Novobiocin biosynthesis;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_4_Reaction:
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00155:Aminotran_1_2;
PF07706:TAT_ubiq

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.6.1.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
36713

# Metabolic_Enzyme_4_SwissProt_ID:
ATTY_HUMAN (P17735)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
TAT

# Metabolic_Enzyme_4_Geneatlas_id:
TAT

# Metabolic_Enzyme_4_hgnc_id:
HGNC:11573

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>1365 bp
ATGGACCCATACATGATTCAGATGAGCAGCAAAGGCAACCTCCCCTCAATTCTGGACGTG
CATGTCAACGTTGGTGGGAGAAGCTCTGTGCCGGGAAAAATGAAAGGCAGAAAGGCCAGG
TGGTCTGTGAGGCCCTCAGACATGGCCAAGAAAACTTTCAACCCCATCCGAGCCATTGTG
GACAACATGAAGGTGAAACCAAATCCAAACAAAACCATGATTTCCCTGTCCATTGGGGAC
CCTACTGTGTTTGGAAACCTGCCTACAGACCCTGAAGTTACCCAGGCAATGAAAGATGCC
CTGGACTCGGGCAAATATAATGGCTATGCCCCATCCATCGGCTTCCTATCCAGTCGGGAG
GAGATTGCTTCTTATTACCACTGTCCTGAGGCACCCCTAGAAGCTAAGGACGTCATTCTG
ACAAGTGGCTGCAGCCAAGCTATTGACCTTTGTTTAGCTGTGTTGGCCAACCCAGGGCAG
AACATCCTGGTTCCAAGACCTGGTTTCTCTCTCTACAAGACTCTGGCTGAGTCTATGGGA
ATTGAGGTCAAACTCTACAATTTGTTGCCAGAGAAATCTTGGGAAATTGACCTGAAACAA
CTGGAATATCTAATTGATGAAAAGACAGCTTGTCTCATTGTCAATAATCCATCAAACCCC
TGTGGGTCAGTGTTCAGCAAACGTCATCTTCAGAAGATTCTGGCAGTGGCTGCACGGCAG
TGTGTCCCCATCTTAGCTGATGAGATCTATGGAGACATGGTGTTTTCGGATTGCAAATAT
GAACCACTGGCCACCCTCAGCACCGATGTCCCCATCCTGTCCTGTGGAGGGCTGGCCAAG
CGCTGGCTGGTTCCTGGCTGGAGGTTGGGCTGGATCCTCATTCATGACCGAAGAGACATT
TTTGGCAATGAGATCCGAGATGGGCTGGTGAAGCTGAGTCAGCGCATTTTGGGACCCTGT
ACCATTGTCCAGGGAGCTCTGAAAAGCATCCTATGTCGCACCCCGGGAGAGTTTTACCAC
AACACTCTGAGCTTCCTCAAGTCCAATGCTGATCTCTGTTATGGGGCGTTGGCTGCCATC
CCTGGACTCCGGCCAGTCCGCCCTTCTGGGGCTATGTACCTCATGGTTGGAATTGAGATG
GAACATTTCCCAGAATTTGAGAACGATGTGGAGTTCACGGAGCGGTTAGTTGCTGAGCAG
TCTGTCCACTGCCTCCCAGCAACGTGCTTTGAGTACCCGAATTTCATCCGAGTGGTCATC
ACAGTCCCCGAGGTGATGATGCTGGAGGCGTGCAGCCGGATCCAGGAGTTCTGTGAGCAG
CACTACCATTGTGCTGAAGGCAGCCAGGAGGAGTGTGATAAATAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
X52520

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_4_Locus:
16q22.1

# Metabolic_Enzyme_4_SNPs:
rs16973331; rs2432520; rs172650; rs2113223; rs2247603; rs2432519; rs9939332; rs13339247; rs13338868; rs16973337; rs1364210; rs1477386; rs2032921; rs3829537; rs2432521; rs3794689; rs2432522; rs11075889; rs8063455; rs1477387; rs9930543; rs11862798; rs16973344; rs34508506; rs12924334; rs11648913; rs2303226; rs3764308; rs34104038; rs36000068; rs35082722; rs34753286; rs2161674; rs8064108; rs1799881; rs3036400; rs3057106; rs8063793; rs34263853; rs1477388; rs34131262; rs1544808; rs1073060; rs12598228; rs1428834; rs1428835; rs2434886; rs4788809

# Metabolic_Enzyme_4_General_References:
1973834; 7908801; 7999802; 1357662

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5510

# Metabolic_Enzyme_5_Name:
Aromatic-L-amino-acid decarboxylase

# Metabolic_Enzyme_5_Synonyms:
AADC; DOPA decarboxylase; DDC

# Metabolic_Enzyme_5_Gene_Name:
DDC

# Metabolic_Enzyme_5_Protein_Sequence:
>AromaticLaminoacid decarboxylase
MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV
EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD
WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM
EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV
ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN
PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL
KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN
EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE


# Metabolic_Enzyme_5_Number_of_Residues:
480

# Metabolic_Enzyme_5_Molecular_Weight:
53895

# Metabolic_Enzyme_5_Theoretical_pI:
7.21

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
 ||
>>>
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine

# Metabolic_Enzyme_5_Pathway:
map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00901  Indole and ipecac alkaloid biosynthesis;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_5_Reaction:
L-tryptophan = tryptamine + CO2

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00282:Pyridoxal_deC

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 4.1.1.28

# Metabolic_Enzyme_5_GenBank_ID_Protein:
181521

# Metabolic_Enzyme_5_SwissProt_ID:
DDC_HUMAN (P20711)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
DDC

# Metabolic_Enzyme_5_Geneatlas_id:
DDC

# Metabolic_Enzyme_5_hgnc_id:
HGNC:2719

# Metabolic_Enzyme_5_PDB_ID:
1JS3

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Not Available

# Metabolic_Enzyme_5_Gene_Sequence:
>1443 bp
ATGAACGCAAGTGAATTCCGAAGGAGAGGGAAGGAGATGGTGGATTACGTGGCCAACTAC
ATGGAAGGCATTGAGGGACGCCAGGTCTACCCTGACGTGGAGCCCGGGTACCTGCGGCCG
CTGATCCCTGCCGCTGCCCCTCAGGAGCCAGACACGTTTGAGGACATCATCAACGACGTT
GAGAAGATAATCATGCCTGGGGTGACGCACTGGCACAGCCCCTACTTCTTCGCCTACTTC
CCCACTGCCAGCTCGTACCCGGCCATGCTTGCGGACATGCTGTGCGGGGCCATTGGCTGC
ATCGGCTTCTCCTGGGCGGCAAGCCCAGCATGCACAGAGCTGGAGACTGTGATGATGGAC
TGGCTCGGGAAGATGCTGGAACTACCAAAGGCATTTTTGAATGAGAAAGCTGGAGAAGGG
GGAGGAGTGATCCAGGGAAGTGCCAGTGAAGCCACCCTGGTGGCCCTGCTGGCCGCTCGG
ACCAAAGTGATCCATCGGCTGCAGGCAGCGTCCCCAGAGCTCACACAGGCCGCTATCATG
GAGAAGCTGGTGGCTTACTCATCCGATCAGGCACACTCCTCAGTGGAAAGAGCTGGGTTA
ATTGGTGGAGTGAAATTAAAAGCCATCCCCTCAGATGGCAACTTCGCCATGCGTGCGTCT
GCCCTGCAGGAAGCCCTGGAGAGAGACAAAGCGGCTGGCCTGATTCCTTTCTTTATGGTT
GCCACCCTGGGGACCACAACATGCTGCTCCTTTGACAATCTCTTAGAAGTCGGTCCTATC
TGCAACAAGGAAGACATATGGCTGCACGTTGATGCAGCCTACGCAGGCAGTGCATTCATC
TGCCCTGAGTTCCGGCACCTTCTGAATGGAGTGGAGTTTGCAGATTCATTCAACTTTAAT
CCCCACAAATGGCTATTGGTGAATTTTGACTGTTCTGCCATGTGGGTGAAAAAGAGAACA
GACTTAACGGGAGCCTTTAGACTGGACCCCACTTACCTGAAGCACAGCCATCAGGATTCA
GGGCTTATCACTGACTACCGGCATTGGCAGATACCACTGGGCAGAAGATTTCGCTCTTTG
AAAATGTGGTTTGTATTTAGGATGTATGGAGTCAAAGGACTGCAGGCTTATATCCGCAAG
CATGTCCAGCTGTCCCATGAGTTTGAGTCACTGGTGCGCCAGGATCCCCGCTTTGAAATC
TGTGTGGAAGTCATTCTGGGGCTTGTCTGCTTTCGGCTAAAGGGTTCCAACAAAGTGAAT
GAAGCTCTTCTGCAAAGAATAAACAGTGCCAAAAAAATCCACTTGGTTCCATGTCACCTC
AGGGACAAGTTTGTCCTGCGCTTTGCCATCTGTTCTCGCACGGTGGAATCTGCCCATGTG
CAGCGGGCCTGGGAACACATCAAAGAGCTGGCGGCCGACGTGCTGCGAGCAGAGAGGGAG
TAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M76180

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_5_Locus:
7p11

# Metabolic_Enzyme_5_SNPs:
rs6263; rs6262; rs11575542; rs11575292; rs6264; rs11575302; rs11575290; rs921451; rs2329342; rs2329371; rs10499694; rs1451374; rs10276473; rs6949897; rs4452748; rs921450; rs7803440; rs7803788; rs1470747; rs1451375; rs6969081; rs1966839; rs7803903; rs10249420; rs1451373; rs10265930; rs10499695; rs7786398; rs11575548; rs11974297; rs10250513; rs11575551; rs1349491; rs11575549; rs2060762; rs11575288; rs2329341; rs2329343; rs11575286; rs11575550; rs6593002; rs3779074; rs2242041; rs3837091; rs2329340; rs11765748; rs3779075; rs2044859; rs10499696; rs7779110; rs2876830; rs2242042; rs3779076; rs4947644; rs11765109; rs930707; rs11575282; rs11575273; rs17133881; rs4585697; rs11575544; rs17133878; rs10255505; rs11575281; rs6956737; rs11575543; rs11575545; rs2060761; rs11575553; rs6962356; rs11575546; rs10229387; rs11575552; rs11575284; rs11575280; rs6972476; rs11575547; rs6975312; rs998850; rs730092; rs896309; rs880028; rs1376524; rs745043; rs6592962; rs10899734; rs7790758; rs3887825; rs3735274; rs6965432; rs4948196; rs11761683; rs11238134; rs10899735; rs1451371; rs3807556; rs4947580; rs6951323; rs6950777; rs4580999; rs9942686; rs10277662; rs4947584; rs2198144; rs6592961; rs3779078; rs11983581; rs1037351; rs4436083; rs1901312; rs3807552; rs11983757; rs1451372; rs2167364; rs11772714; rs4947577; rs11575457; rs11768267; rs11575334; rs3735273; rs7809758; rs11575320; rs11980368; rs4377912; rs6957607; rs4947582; rs7776816; rs11981575; rs11575464; rs4948201; rs6967361; rs1451370; rs11575536; rs6944090; rs17133853; rs2876827; rs11575340; rs10244632; rs11575489; rs6592952; rs6952023; rs10228056; rs896308; rs11974997; rs11575518; rs4602840; rs11575378; rs11575527; rs11575375; rs12718541; rs11575387; rs745042; rs1817074; rs4579483; rs7791875; rs2122822; rs11575399; rs11575511; rs4947535; rs11575351; rs1376523; rs4992502; rs6947293; rs11575435; rs11575407; rs11575338; rs11575516; rs11763837; rs11575400; rs17133842; rs11575520; rs7777600; rs4397355; rs1901311; rs10274275; rs11575451; rs11575538; rs4948197; rs11575388; rs4947634; rs12667533; rs10268819; rs11575441; rs11575506; rs3779084; rs6974583; rs17133877; rs12718527; rs3807566; rs6979229; rs11238138; rs10499693; rs11982708; rs1982406; rs2329367; rs2100280; rs11238133; rs3807555; rs11575461; rs2876829; rs7803247; rs10899736; rs6951648; rs1007702; rs11575500; rs11771818; rs11575444; rs11575541; rs4329234; rs11575442; rs10239830; rs9918702; rs11575501; rs1007749; rs11575494; rs4947576; rs11575523; rs7780360; rs6963534; rs11982772; rs11575309; rs4947581; rs11575462; rs1349492; rs732215; rs11575322; rs2329365; rs10271341; rs4989851; rs3807558; rs11575298; rs4433100; rs11575537; rs731689; rs4490786; rs4245549; rs896307; rs17634958; rs3757472; rs4470989; rs11238131; rs11575535; rs11982776; rs7808025; rs3807562; rs11575404; rs2122817; rs11575522; rs6592963; rs5884156; rs3807553; rs10249982; rs11575510; rs1470750; rs4947631; rs11575463; rs12718572; rs12535024; rs2329366; rs11575383; rs6955487; rs2122821; rs17665398; rs11765543; rs7809477; rs12538938; rs11575327; rs11575521; rs1451369; rs12112308; rs11575360; rs17553495; rs11575454; rs1817073; rs11575447; rs2167367; rs3823674; rs11575450; rs11575507; rs11575319; rs11575301; rs17152014; rs10239937; rs6970468; rs11575295; rs7785224; rs4947621; rs17733244; rs3470; rs4449741; rs11575532; rs11575460; rs2167366; rs17634717; rs3779083; rs11575423; rs11575504; rs880029; rs17553791; rs6952381; rs11575502; rs9918591; rs11575406; rs11771860; rs11575519; rs1451368; rs2122818; rs11575372; rs11575343; rs11575300; rs11575368; rs11575381; rs13222408; rs11575509; rs12718574; rs11575455; rs11575540; rs11768997; rs7797142; rs17635123; rs7792578; rs11575515; rs11575526; rs11575491; rs11767384; rs6953675; rs7807564; rs11575385; rs2329364; rs11575332; rs11575512; rs11575296; rs12665948; rs11575428; rs11575305; rs11575323; rs11575503; rs11575339; rs11575449; rs6964142; rs2122819; rs11575304; rs2876826; rs11575342; rs11767334; rs11575456; rs17152020; rs11575472; rs4948225; rs11575313; rs3807563; rs7792474; rs11575525; rs11978797; rs10267323; rs2329368; rs11575424; rs2100279; rs11575434; rs6963996; rs11575513; rs11575534; rs11763051; rs11575411; rs11575392; rs11575425; rs11575505; rs11575328; rs17665588; rs11575431; rs4947625; rs6592969; rs11575349; rs11575353; rs2060763; rs12718528; rs11575293; rs11575492; rs6944912; rs11575356; rs2329369; rs11575429; rs11575438; rs7802199; rs3887826; rs11575453; rs11575414; rs11575321; rs2876828; rs12535064; rs7812167; rs6592973; rs11575508; rs1807066; rs1304691; rs11575437; rs11575514; rs17634771; rs1466163; rs11575374; rs7809234; rs3779082; rs11575430; rs12671474; rs11575422; rs7810677; rs3071970; rs11575446; rs11575410; rs11575325; rs2167363; rs17665670; rs13311361; rs11575352; rs11575483; rs11575413; rs7778349; rs6975453; rs11575359; rs12718529; rs1451366; rs11575531; rs11575493; rs1597639; rs11575528; rs4948010; rs4947510; rs3829897; rs11575575; rs6593010; rs11575557; rs4947511; rs11575565; rs11575568; rs11575564; rs11575574; rs11575266; rs10278338; rs11575562; rs11575259; rs11575264; rs11575561; rs11575570; rs11575271; rs11575566; rs11575569; rs11575267; rs11575556; rs11575268; rs11575376; rs11575377; rs11575291; rs12670911; rs10233346; rs11575274; rs28607134; rs28799122; rs34618339; rs13223166; rs11302809; rs4515495; rs10281167; rs34752519; rs2242040; rs13223157; rs13233973; rs13245496; rs2242039; rs5884158; rs13237075; rs2329370; rs28510954; rs10600316; rs10229102; rs13226079; rs3071145; rs11366731; rs10601831; rs35197006; rs7791943; rs2242038; rs5014165; rs13226287; rs7782081; rs12718674; rs11575276; rs2167368; rs10255145; rs11575277; rs34606153; rs6975015; rs11410259; rs10229369; rs10247443; rs11575275; rs10609620; rs7787209; rs13245018; rs34348593; rs1988550; rs35330002; rs35591152; rs11450560; rs11575468; rs34658291; rs11575395; rs35299591; rs34021747; rs35586188; rs11575432; rs34314851; rs35089176; rs35997922; rs12537169; rs12718558; rs11575294; rs1470749; rs11315611; rs11575315; rs13228083; rs35582115; rs4947588; rs13308328; rs3779077; rs3807554; rs5884157; rs7811992; rs12718563; rs36110443; rs11575482; rs11330628; rs1107742; rs731690; rs11575433; rs4948216; rs11575311; rs11575326; rs6965025; rs11575347; rs11575474; rs11575316; rs11575459; rs35993062; rs3840579; rs11575314; rs11575465; rs5884154; rs3779080; rs34950596; rs2198143; rs10718396; rs10587155; rs36090705; rs34869137; rs11575533; rs3071964; rs13234331; rs34002033; rs1137337; rs34977933; rs3779081; rs35173748; rs1470748; rs12538830; rs4947594; rs11575497; rs35008528; rs4947589; rs2084723; rs11575306; rs34971815; rs34780941; rs13222708; rs11575346; rs1107743; rs6953661; rs12718583; rs11575329; rs6959596; rs36104801; rs7794360; rs11763809; rs13244875; rs11575362; rs11575415; rs28889020; rs35666388; rs35765995; rs6968322; rs11575389; rs11761208; rs33974864; rs6975747; rs13232900; rs34329145; rs11575369; rs7810684; rs11978769; rs4143196; rs28706313; rs3071975; rs7781950; rs28534613; rs12718611; rs4377913; rs1580031; rs5884155; rs28531762; rs34984600; rs11309882; rs11575318; rs35539624; rs11575333; rs36063027; rs11980236; rs7785984; rs35432113; rs34298125; rs11575363; rs7455902; rs7786752; rs10258321; rs34582666; rs11575397; rs11575530; rs4455783; rs11575529; rs11575312; rs33945116; rs4948205; rs1304693; rs11575401; rs35915381; rs2122820; rs34487683; rs11763807; rs13225182; rs6960966; rs34791889; rs36005269; rs11575303; rs6952938; rs6964313; rs10710723; rs11575417; rs1901313; rs11378977; rs11575524; rs11575394; rs13229021; rs11575308; rs11575348; rs12666643; rs11575499; rs35269833; rs11575393; rs11575330; rs4052336; rs3071963; rs11575458; rs11575367; rs13228086; rs35484306; rs7793185; rs11575390; rs12537186; rs35092758; rs3807557; rs11575555; rs11575554; rs11575269; rs11575567; rs11575257; rs11575559; rs11575265; rs11575261; rs11575571; rs11575270; rs11575572; rs35937247; rs11575260; rs4947662; rs13243080; rs11575563; rs35517528; rs10499697; rs11238214; rs11489734; rs11977135; rs12666409; rs13228274; rs3911193; rs4947396; rs6593011; rs7790230; rs7804365; rs7807335; rs978784

# Metabolic_Enzyme_5_General_References:
2590185; 1612608; 1540578; 8510497; 1395716; 10391209

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5511

# Metabolic_Enzyme_6_Name:
Lactoperoxidase precursor

# Metabolic_Enzyme_6_Synonyms:
LPO; Salivary peroxidase; SPO

# Metabolic_Enzyme_6_Gene_Name:
LPO

# Metabolic_Enzyme_6_Protein_Sequence:
>Lactoperoxidase precursor
MRVLLHLPALLASLILLQAAASTTRAQTTRTSAISDTVSQAKVQVNKAFLDSRTRLKTAM
SSETPTSRQLSEYLKHAKGRTRTAIRNGQVWEESLKRLRQKASLTNVTDPSLDLTSLSLE
VGCGAPAPVVRCDPCSPYRTITGDCNNRRKPALGAANRALARWLPAEYEDGLSLPFGWTP
GKTRNGFPLPLAREVSNKIVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELGSSE
YSKAQCDEYCIQGDNCFPIMFPPNDPKAGTQGKCMPFFRAGFVCPTPPYKSLAREQINAL
TSFLDASFVYSSEPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPYDSKKPSPCEFINTT
ARVPCFLAGDSRASEHILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQEARKILGAF
VQIITFRDYLPILLGDHMQKWIPPYQGYSESVDPRISNVFTFAFRFGHLEVPSSMFRLDE
NYQPWGPEPELPLHTLFFNTWRMVKDGGIDPLVRGLLAKKSKLMKQNKMMTGELRNKLFQ
PTHRIHGFDLAAINTQRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKKLLGL
YGTPDNIDIWIGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENPGVFTNEQKDS
LQKMSFSRLVCDNTRITKVPRDPFWANSYPYDFVDCSAIDKLDLSPWASVKN

# Metabolic_Enzyme_6_Number_of_Residues:
712

# Metabolic_Enzyme_6_Molecular_Weight:
80289

# Metabolic_Enzyme_6_Theoretical_pI:
8.76

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Donor + H(2)O(2) = oxidized donor + 2 H(2)O

# Metabolic_Enzyme_6_Pathway:
map00360  Phenylalanine metabolism;
 map00590  Prostaglandin and leukotriene metabolism;
 map00680  Methane metabolism;
 map00940  Stilbene, coumarine and lignin biosynthesis

# Metabolic_Enzyme_6_Reaction:
donor + H2O2 = oxidized donor + 2 H2O

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF03098:An_peroxidase

# Metabolic_Enzyme_6_Signals:
1-26

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.11.1.7

# Metabolic_Enzyme_6_GenBank_ID_Protein:
1209685

# Metabolic_Enzyme_6_SwissProt_ID:
PERL_HUMAN (P22079)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
LPO

# Metabolic_Enzyme_6_Geneatlas_id:
LPO

# Metabolic_Enzyme_6_hgnc_id:
HGNC:6678

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_6_Gene_Sequence:
>2139 bp
ATGAGGGTCCTTCTCCATCTCCCAGCCCTCCTGGCTTCCCTCATCTTGCTTCAGGCTGCA
GCATCTACCACAAGAGCGCAGACTACCAGAACCTCTGCCATCTCCGATACTGTGAGTCAG
GCCAAGGTCCAAGTCAACAAGGCCTTCCTGGACTCCCGAACCAGGCTGAAGACCGCCATG
AGCTCTGAGACTCCCACCAGCCGACAGCTCTCAGAATACCTCAAGCATGCCAAAGGCCGG
ACGCGCACAGCCATCCGCAATGGACAGGTGTGGGAGGAGTCTTTAAAGAGACTGAGGCAG
AAGGCATCCTTGACCAATGTCACAGATCCCAGCCTGGACTTGACTTCACTGTCTCTGGAG
GTGGGCTGTGGTGCTCCTGCTCCCGTGGTGAGATGCGACCCGTGCAGCCCTTACCGCACC
ATTACGGGAGACTGCAATAACAGGAGGAAGCCTGCGCTGGGCGCCGCCAACAGGGCTCTG
GCGCGCTGGCTGCCCGCGGAGTACGAGGACGGGCTCTCCCTGCCCTTCGGCTGGACGCCG
GGGAAGACGCGCAACGGCTTCCCTCTCCCGCTGGCCCGGGAGGTATCTAACAAGATTGTT
GGCTATCTGAATGAGGAGGGTGTTCTGGACCAAAACAGGTCCCTGCTCTTCATGCAGTGG
GGTCAGATTGTGGATCATGACCTGGACTTTGCCCCTGACACCGAGCTGGGGAGTAGCGAG
TACTCCAAAGCCCAGTGTGATGAGTACTGTATCCAGGGAGACAACTGCTTCCCCATCATG
TTCCCACCCAATGACCCCAAGGCGGGGACTCAAGGGAAATGCATGCCTTTCTTCCGAGCT
GGGTTCGTCTGCCCCACTCCACCCTACAAGTCCCTGGCCCGAGAGCAGATCAACGCTCTG
ACCTCCTTCCTGGATGCCAGCTTTGTGTACAGCTCCGAGCCAAGCCTGGCCAGCCGCCTC
CGCAACCTCAGCAGCCCCCTGGGCCTCATGGCTGTCAACCAGGAGGTCTCAGACCATGGA
CTACCCTACCTGCCCTATGACAGCAAGAAGCCAAGCCCCTGTGAGTTCATCAACACCACT
GCCCGTGTGCCCTGCTTCCTGGCAGGAGATTCTCGAGCCTCAGAGCATATTCTGCTGGCC
ACATCCCACACCCTCTTTCTCCGCGAGCATAACCGGCTGGCCAGAGAACTAAAGAGACTC
AACCCTCAGTGGGATGGAGAGAAGCTCTACCAGGAAGCCCGGAAAATCCTGGGAGCCTTC
GTGCAGATTATCACCTTTAGGGACTACCTACCCATTTTGCTAGGTGACCACATGCAGAAG
TGGATACCCCCATATCAAGGCTACAGTGAATCTGTGGATCCCAGAATTTCCAATGTCTTC
ACCTTCGCCTTCCGCTTTGGCCACTTGGAGGTCCCCTCTAGTATGTTCCGCCTGGATGAG
AATTATCAGCCATGGGGGCCAGAACCAGAACTCCCCCTCCACACCCTCTTCTTCAACACT
TGGAGGATGGTCAAAGATGGTGGAATTGATCCTCTGGTGCGGGGCCTGCTGGCCAAGAAA
TCCAAGCTGATGAAACAGAATAAAATGATGACTGGAGAGCTGCGCAACAAGCTTTTCCAG
CCAACTCACAGGATCCATGGCTTTGACCTGGCTGCCATCAACACACAGCGTTGCCGGGAC
CATGGGCAACCTGGGTACAATTCCTGGAGAGCCTTCTGTGACCTCTCACAGCCGCAGACA
CTAGAGGAGTTGAACACAGTGCTGAAGAGCAAGATGCTGGCCAAGAAGTTACTGGGTCTC
TACGGGACCCCTGACAACATCGACATCTGGATAGGGGCCATTGCTGAGCCGCTGGTGGAA
AGGGGTCGGGTGGGGCCTCTCCTGGCCTGCCTCTTGGGCAAGCAGTTCCAGCAGATCCGT
GATGGAGACAGGTTCTGGTGGGAAAACCCTGGGGTCTTCACGAACGAGCAGAAGGACTCT
CTACAGAAAATGTCCTTCTCACGCCTTGTCTGTGACAACACCCGCATCACCAAGGTCCCA
CGGGACCCATTCTGGGCCAACAGCTACCCCTATGACTTCGTGGATTGCTCAGCCATCGAC
AAGCTGGACCTGTCACCCTGGGCCTCAGTGAAGAATTAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
U39573

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_6_Locus:
17q23.1

# Metabolic_Enzyme_6_SNPs:
rs2301870; rs8178318; rs8178338; rs8178329; rs8178409; rs8178291; rs2240263; rs8178289; rs8178278; rs8178281; rs8178290; rs3760168; rs36045682; rs8178279; rs8071513; rs8178287; rs8072167; rs35073145; rs8178283; rs8178277; rs8178286; rs2240262; rs8178282; rs8178285; rs8178288; rs8178275; rs8071342; rs8178284; rs8178414; rs8178280; rs8178407; rs7208924; rs6503856; rs8178359; rs11868650; rs7209537; rs7218620; rs7226197; rs8178374; rs11656836; rs7219860; rs8178376; rs8178385; rs8178369; rs8178309; rs8178392; rs8178390; rs8178299; rs8178304; rs8178319; rs8178380; rs8178386; rs8178350; rs8178377; rs8178384; rs8178375; rs8178326; rs8178306; rs8178400; rs8178301; rs8178313; rs8178298; rs8178387; rs8178334; rs8178297; rs8178307; rs8178302; rs8178405; rs8178371; rs8178323; rs4319828; rs8178363; rs8178378; rs8178348; rs8178361; rs8178373; rs8178294; rs8178381; rs8178411; rs8178406; rs4319829; rs8178340; rs8178379; rs7212017; rs8178367; rs11871239; rs8178300; rs8178310; rs11652686; rs8178354; rs9912140; rs8178410; rs8178292; rs8178325; rs8178346; rs8178314; rs8178337; rs2301869; rs8178368; rs8178364; rs8178295; rs8178330; rs8178322; rs8178327; rs8178331; rs8178357; rs8178402; rs8178394; rs8178342; rs12453852; rs8178345; rs8178312; rs8178308; rs8178360; rs8178403; rs8178316; rs8178311; rs7222295; rs8077532; rs8067912; rs8178422; rs7501989; rs35465594; rs8067921; rs8178274; rs8178273; rs8178423; rs35454288; rs8178272; rs8178355; rs8178412; rs8178401; rs8178408; rs8178332; rs3744104; rs8178398; rs8178413; rs11650655; rs8178276; rs8178417; rs8178416; rs34853811; rs10706194; rs8178415; rs8080395; rs8178418; rs8178315; rs34548791; rs8178324; rs34725319; rs8178351; rs8178305; rs7217459; rs8178389; rs8178293; rs35253156; rs8178336; rs36116507; rs8178320; rs9903953; rs8178296; rs5821219; rs8178344; rs11337012; rs8178365; rs9904174; rs35568007; rs35362405; rs36028795; rs8178333; rs8178397; rs12952947; rs34872363; rs8067538; rs8178388; rs8178321; rs8178349; rs8178370; rs8178393; rs8178391; rs8178358; rs10546431; rs8178343; rs8178404; rs9894824; rs8178353; rs11868675; rs8178372; rs8178383; rs35768639; rs35410749; rs8178341; rs8067149; rs8178382; rs35691433; rs8178399; rs34378381; rs8178317; rs8178335; rs5821221; rs35302486; rs8178366; rs8067533; rs8178339; rs9904175; rs8067137; rs34122568; rs3886628; rs8178352; rs28872572; rs35558964; rs8178356; rs34318642; rs8178328; rs8178362; rs8178347; rs4793581; rs5821220; rs35476666; rs8178303; rs34632576; rs8178421; rs34893621; rs35516386; rs8178420; rs8178419; rs35734445; rs35413598; rs11575868; rs11653648; rs11867630; rs17762644; rs2071409; rs2107546; rs2526362; rs2526363; rs2526365; rs2759; rs2856853; rs2856865; rs28730835; rs4531800; rs6503857; rs7208439; rs7220117; rs725663; rs8067377; rs8073898; rs8082134; rs8178395; rs916114; rs916115; rs916116; rs9911495

# Metabolic_Enzyme_6_General_References:
8964511; 2222811

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5512

# Metabolic_Enzyme_7_Name:
Phenylalanine-4-hydroxylase

# Metabolic_Enzyme_7_Synonyms:
PAH; Phe-4- monooxygenase

# Metabolic_Enzyme_7_Gene_Name:
PAH

# Metabolic_Enzyme_7_Protein_Sequence:
>Phenylalanine4hydroxylase
MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDV
NLTHIESRPS
RLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVP
WFPRTIQELDRFANQILSYGA
ELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVE
YMEEEKKTWGTVFKTLKSLYKTHACYEYNHIF
PLLEKYCGFHEDNIPQLEDVSQFLQTC
TGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPE
PDICHELLGHVPLFSD
RSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSS
FGELQ
YCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYD
PYTQR
IEVLDNTQQLKILADSINSEIGILCSALQKIK

# Metabolic_Enzyme_7_Number_of_Residues:
452

# Metabolic_Enzyme_7_Molecular_Weight:
51863

# Metabolic_Enzyme_7_Theoretical_pI:
6.57

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  phenylalanine 4-monooxygenase activity
Function:  amine binding
Function:  amino acid binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  L-phenylalanine metabolism
Process:  L-phenylalanine catabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
L-phenylalanine + tetrahydrobiopterin + O(2) = L-tyrosine + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_7_Pathway:
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis

# Metabolic_Enzyme_7_Reaction:
L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF01842:ACT;
PF00351:Biopterin_H

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.14.16.1

# Metabolic_Enzyme_7_GenBank_ID_Protein:
189937

# Metabolic_Enzyme_7_SwissProt_ID:
PH4H_HUMAN (P00439)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
PAH

# Metabolic_Enzyme_7_Geneatlas_id:
PAH

# Metabolic_Enzyme_7_hgnc_id:
HGNC:8582

# Metabolic_Enzyme_7_PDB_ID:
2PHM

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>1359 bp

ATGTCCACTGCGGTCCTGGAAAACCCAGGCTTGGGCAGGAAACTCTCTGACTTTGGACA
GGAAACAAGCT
ATATTGAAGACAACTGCAATCAAAATGGTGCCATATCACTGATCTTCT
CACTCAAAGAAGAAGTTGGTGC
ATTGGCCAAAGTATTGCGCTTATTTGAGGAGAATGAT
GTAAACCTGACCCACATTGAATCTAGACCTTCT
CGTTTAAAGAAAGATGAGTATGAATT
TTTCACCCATTTGGATAAACGTAGCCTGCCTGCTCTGACAAACA
TCATCAAGATCTTGA
GGCATGACATTGGTGCCACTGTCCATGAGCTTTCACGAGATAAGAAGAAAGACAC
AGTG
CCCTGGTTCCCAAGAACCATTCAAGAGCTGGACAGATTTGCCAATCAGATTCTCAGCTAT
GGAGCG
GAACTGGATGCTGACCACCCTGGTTTTAAAGATCCTGTGTACCGTGCAAGACG
GAAGCAGTTTGCTGACA
TTGCCTACAACTACCGCCATGGGCAGCCCATCCCTCGAGTGG
AATACATGGAGGAAGAAAAGAAAACATG
GGGCACAGTGTTCAAGACTCTGAAGTCCTTG
TATAAAACCCATGCTTGCTATGAGTACAATCACATTTTT
CCACTTCTTGAAAAGTACTG
TGGCTTCCATGAAGATAACATTCCCCAGCTGGAAGACGTTTCTCAATTCC
TGCAGACTT
GCACTGGTTTCCGCCTCCGACCTGTGGCTGGCCTGCTTTCCTCTCGGGATTTCTTGGGTG
G
CCTGGCCTTCCGAGTCTTCCACTGCACACAGTACATCAGACATGGATCCAAGCCCATG
TATACCCCCGAA
CCTGACATCTGCCATGAGCTGTTGGGACATGTGCCCTTGTTTTCAGA
TCGCAGCTTTGCCCAGTTTTCCC
AGGAAATTGGCCTTGCCTCTCTGGGTGCACCTGATG
AATACATTGAAAAGCTCGCCACAATTTACTGGTT
TACTGTGGAGTTTGGGCTCTGCAAA
CAAGGAGACTCCATAAAGGCATATGGTGCTGGGCTCCTGTCATCC
TTTGGTGAATTACA
GTACTGCTTATCAGAGAAGCCAAAGCTTCTCCCCCTGGAGCTGGAGAAGACAGCCA
TCC
AAAATTACACTGTCACGGAGTTCCAGCCCCTGTATTACGTGGCAGAGAGTTTTAATGATG
CCAAGGA
GAAAGTAAGGAACTTTGCTGCCACAATACCTCGGCCCTTCTCAGTTCGCTAC
GACCCATACACCCAAAGG
ATTGAGGTCTTGGACAATACCCAGCAGCTTAAGATTTTGGC
TGATTCCATTAACAGTGAAATTGGAATCC
TTTGCAGTGCCCTCCAGAAAATAAAGTAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
K03020

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_7_Locus:
12q22-q24.2

# Metabolic_Enzyme_7_SNPs:
rs5030849; rs1042503; rs1126758; rs1801152; rs772897; rs2280615; rs1801153; rs2280616; rs1616681; rs1722387; rs940527; rs772893; rs937475; rs1722383; rs1522295; rs2251897; rs1718305; rs1722392; rs1617090; rs2133298; rs2245360; rs12425434; rs2270729; rs11111419; rs10860933; rs1718312; rs10860929; rs2242381; rs1722381; rs1498688; rs1718303; rs1498694; rs2252031; rs2247836; rs2251905; rs10860936; rs2037639; rs2056602; rs4646986; rs12580432; rs1522296; rs10860928; rs1522307; rs10778202; rs2712618; rs10860935; rs10512929; rs10860931; rs4764918; rs1718301; rs772896; rs1353766; rs11836916; rs1718307; rs798709; rs11111412; rs1357765; rs10778201; rs12297049; rs4264203; rs10860930; rs1522304; rs3847931; rs869916; rs7295308; rs1718300; rs772895; rs1391685; rs1718304; rs1718306; rs4646987; rs10778204; rs1915932; rs940528; rs937476; rs1814728; rs1722399; rs7310181; rs1072528; rs1568795; rs2251799; rs870072; rs3805120; rs12306510; rs937474; rs3805122; rs1718297; rs10778209; rs7964033; rs2251894; rs1353767; rs7131709; rs17842947; rs1718302; rs11111413; rs6539058; rs7485666; rs3847930; rs12302563; rs1568792; rs1718310; rs10860934; rs7295112; rs7295979; rs10778205; rs11838076; rs772894; rs1718298; rs7485659; rs1722382; rs10778208; rs1722389; rs12309781; rs7138986; rs12578292; rs2454388; rs11830620; rs3817446; rs11831257; rs11111408; rs7488136; rs7485655; rs11838082; rs7488937; rs12301066; rs34181115; rs34191345; rs3828473; rs772899; rs12309687; rs1718292; rs7958897; rs7958750; rs35774237; rs772898; rs1851381; rs10778203; rs11111411; rs10778207; rs12579415; rs11830089; rs10778200; rs3913258; rs12099586; rs12831013; rs1106703; rs11111414; rs12581989; rs17033372; rs7487151; rs1522306; rs3828474; rs1722390; rs11830010; rs2953059; rs11111410; rs7485683; rs10778206; rs12312872; rs12298125; rs10450750; rs12299182; rs11830600; rs10745953; rs1718311; rs10860932; rs1722401; rs2252026; rs7306260; rs2133296; rs4646988; rs7305565; rs17842946; rs1522305; rs1718299; rs7485331; rs1498691; rs1522299; rs17546516; rs4764917; rs9804733; rs1522297; rs17041406; rs9804734; rs9804735; rs17033310; rs17852373; rs5030860; rs5030850; rs5030844; rs5030859; rs5030853; rs5030845; rs5030841; rs5030858; rs5030846; rs5030857; rs5030842; rs5030847; rs5030856; rs5030843; rs5030848; rs5030854; rs1801145; rs17852374; rs1801146; rs1801147; rs1042575; rs35465699; rs7954004; rs1042517; rs2264807; rs12099867; rs2647897; rs35620841; rs3062641; rs36183603; rs36087290; rs34044682; rs12319699; rs11486309; rs28672962; rs34903440; rs7980371; rs34297779; rs2454390; rs5030855; rs12314561; rs5800541; rs12310461; rs7969007; rs11835429; rs36013270; rs34089141; rs1814727; rs35544736; rs28380089; rs11111416; rs5800545; rs34757647; rs11384108; rs3062683; rs11111403; rs10615224; rs2133295; rs11830601; rs2647898; rs34956913; rs28626587; rs7965426; rs12307398; rs3840258; rs34694965; rs2691046; rs2270730; rs2712619; rs5800539; rs35080156; rs36197099; rs12829528; rs12815628; rs12424675; rs34356627; rs34923793; rs12099657; rs12314229; rs5800540; rs2373950; rs34877550; rs1799970; rs2264808; rs3792590; rs10525182; rs2949366; rs4764717; rs34906755; rs34950520; rs36191797; rs34480214; rs7970760; rs10573967; rs34400076; rs34425560; rs35822536; rs1623295; rs34451887; rs1403053; rs35008014; rs3062642; rs11833762; rs3062651; rs7302089; rs10573968; rs7970836; rs34857170; rs36195189; rs36201576; rs7295778; rs11111415; rs11111404; rs12826510; rs2264805; rs7970576; rs5800538; rs34358876; rs12099871; rs34437790; rs11829260; rs34584245; rs2133297; rs1976893; rs1722391; rs1498692; rs34539983; rs3062690; rs35776069; rs11338333; rs28854495; rs10542654; rs10679406; rs36134134; rs2264624; rs28630510; rs2691045; rs28620071; rs1081847; rs10526127; rs1568791; rs3847932; rs5800537; rs10531439; rs35530192; rs1976895; rs5800543; rs28655776; rs12809761; rs35490165; rs11111409; rs12424546; rs2247184; rs12320836; rs34506832; rs1722384; rs11833709; rs2373951; rs5030852; rs35081455; rs34824304; rs35681476; rs35507682; rs1619404; rs10654199; rs35194286; rs35197515; rs35855475; rs2264625; rs1463823; rs11111405; rs11111418; rs2264806; rs35019215; rs11837660; rs34418090; rs5800535; rs5800536; rs12099868; rs11608454; rs11305173; rs34213541; rs34619720; rs12578276; rs35350743; rs2264623; rs34426190; rs35530065; rs35780730; rs12099870; rs35122890; rs7308175; rs1568793; rs2647899; rs12826142; rs28673013; rs35520828; rs28435260; rs28396626; rs28496869; rs2173444; rs1718309; rs12829846; rs2102005; rs5030861; rs34438405; rs34426240; rs34299540; rs3062645; rs4764919; rs12313998; rs7964941; rs34330841; rs35790027; rs5800542; rs12427231; rs12307663; rs7135561; rs28380242; rs1622379; rs10573966; rs35823784; rs12313245; rs1522298; rs12312033; rs36053636; rs34637625; rs34730283; rs34674687; rs9738302; rs35118563; rs35048664; rs7485315; rs17041408; rs1498690; rs35026116; rs1498689; rs5030654; rs10860925; rs11111402; rs17842962; rs34068029; rs4764916; rs7314670; rs7978669

# Metabolic_Enzyme_7_General_References:
2986678; 2461704; 9406548; 9843368; 9642259; 10694386; 11718561; 1679029; 2246858; 1301187; 8594560; 2840952; 2564729; 2615649; 1975559; 1671810; 2014802; 1672294; 1672290; 1679030; 1709636; 1358789; 1355066; 1363837; 1363838; 8406445; 8098245; 8068076; 8088845; 7833954; 8889583; 8889590; 9048935; 9101291; 9450897; 9521426; 9600453; 9452061; 9452062; 9792407; 9792411; 9852673; 10679941; 11326337; 11180595; 11385716; 11461196

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5513

# Metabolic_Enzyme_8_Name:
Peroxiredoxin-6

# Metabolic_Enzyme_8_Synonyms:
Antioxidant protein 2; 1-Cys peroxiredoxin; 1-Cys PRX; Acidic calcium-independent phospholipase A2; aiPLA2; Non-selenium glutathione peroxidase; NSGPx; 24 kDa protein; Liver 2D page spot 40; Red blood cells page spot 12

# Metabolic_Enzyme_8_Gene_Name:
PRDX6

# Metabolic_Enzyme_8_Protein_Sequence:
>Peroxiredoxin6
MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPE
FAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPA
EKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVD
WKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP

# Metabolic_Enzyme_8_Number_of_Residues:
224

# Metabolic_Enzyme_8_Molecular_Weight:
25035

# Metabolic_Enzyme_8_Theoretical_pI:
6.29

# Metabolic_Enzyme_8_GO_Classification:
Not Available

# Metabolic_Enzyme_8_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_8_Specific_Function:
Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury

# Metabolic_Enzyme_8_Pathway:
map00360  Phenylalanine metabolism;
 map00590  Prostaglandin and leukotriene metabolism;
 map00680  Methane metabolism;
 map00940  Stilbene, coumarine and lignin biosynthesis

# Metabolic_Enzyme_8_Reaction:
2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00578:AhpC-TSA

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.11.1.15;EC 1.11.1.7

# Metabolic_Enzyme_8_GenBank_ID_Protein:
285949

# Metabolic_Enzyme_8_SwissProt_ID:
PRDX6_HUMAN (P30041)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
PRDX6

# Metabolic_Enzyme_8_Geneatlas_id:
PRDX6

# Metabolic_Enzyme_8_hgnc_id:
HGNC:16753

# Metabolic_Enzyme_8_PDB_ID:
1PRX

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasm. Lysosome (By similarity). Cytoplasmic vesicle (By similarity). Note=And also found in lung secretory organelles (By similarity)

# Metabolic_Enzyme_8_Gene_Sequence:
>675 bp
ATGCCCGGAGGTCTGCTTCTCGGGGACGTGGCTCCCAACTTTGAGGCCAATACCACCGTC
GGCCGCATCCGTTTCCACGACTTTCTGGGAGACTCATGGGGCATTCTCTTCTCCCACCCT
CGGGACTTTACCCCAGTGTGCACCACAGAGCTTGGCAGAGCTGCAAAGCTGGCACCAGAA
TTTGCCAAGAGGAATGTTAAGTTGATTGCCCTTTCAATAGACAGTGTTGAGGACCATCTT
GCCTGGAGCAAGGATATCAATGCTTACAATTGTGAAGAGCCCACAGAAAAGTTACCTTTT
CCCATCATCGATGATAGGAATCGGGAGCTTGCCATCCTGTTGGGCATGCTGGATCCAGCA
GAGAAGGATGAAAAGGGCATGCCTGTGACAGCTCGTGTGGTGTTTGTTTTTGGTCCTGAT
AAGAAGCTGAAGCTGTCTATCCTCTACCCAGCTACCACTGGCAGGAACTTTGATGAGATT
CTCAGGGTAGTCATCTCTCTCCAGCTGACAGCAGAAAAAAGGGTTGCCACCCCAGTTGAT
TGGAAGGATGGGGATAGTGTGATGGTCCTTCCAACCATCCCTGAAGAAGAAGCCAAAAAA
CTTTTCCCGAAAGGAGTCTTCACCAAAGAGCTCCCATCTGGCAAGAAATACCTCCGCTAC
ACACCCCAGCCTTAA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
D14662

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_8_Locus:
1q25.1

# Metabolic_Enzyme_8_SNPs:
rs7314; rs4611; rs3833536; rs2000; rs36005931; rs6671141; rs7540065; rs6699179; rs9425724; rs33942654; rs912767; rs7545210; rs9425726; rs9425723; rs35052032; rs35899698; rs35244306; rs35679908; rs35749242; rs34666110; rs35891117; rs35918328; rs35224644; rs9425725; rs34538393; rs34308867; rs34683148; rs35794739; rs34396267; rs35263596; rs34591026; rs34128582; rs4382766; rs13376392; rs4354572; rs11576174; rs33951697; rs35753324; rs35581908; rs9425722; rs34977864; rs12739142; rs34129563; rs35280274; rs35133735; rs35441546; rs35846760; rs34619706; rs11543991; rs1804054; rs11543992; rs1804052; rs35232327; rs1801290; rs15269; rs35820016; rs3211528; rs1804051; rs11544001; rs15268; rs34931994; rs1043105; rs11543999; rs1804053; rs35683111; rs1043076; rs35570547; rs35356806; rs1804055; rs35364344; rs34404886; rs34756545; rs35672510; rs35491622; rs35524874; rs35605626; rs10677863; rs12729437; rs1800698; rs35498561; rs34272791; rs11365317; rs35523333; rs35949688; rs34761659; rs34634798; rs35838749; rs34735145; rs28475280; rs7542869; rs12729128; rs34853351; rs35734408; rs9943180; rs34143222; rs12031038; rs34806629; rs28435499; rs13376081; rs35926541; rs34050915; rs35152701; rs34760987; rs10798282; rs12025600; rs13374051; rs4916221; rs4916360; rs4916362; rs6660804; rs6702828; rs6702835; rs7521536

# Metabolic_Enzyme_8_General_References:
8999971; 9050990; 7788527; 12665801; 1286669; 8313871; 9497358; 10893423; 12059788; 9587003

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5514

# Metabolic_Enzyme_9_Name:
Myeloperoxidase precursor

# Metabolic_Enzyme_9_Synonyms:
MPO[Contains: 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain]

# Metabolic_Enzyme_9_Gene_Name:
MPO

# Metabolic_Enzyme_9_Protein_Sequence:
>Myeloperoxidase precursor
MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS
LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH
VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC
NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD
QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND
PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL
GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL
REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR
SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE
GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN
AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL
LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS
NSYPRDFVNCSTLPALNLASWREAS

# Metabolic_Enzyme_9_Number_of_Residues:
745

# Metabolic_Enzyme_9_Molecular_Weight:
83870

# Metabolic_Enzyme_9_Theoretical_pI:
9.14

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity

# Metabolic_Enzyme_9_Pathway:
map00360  Phenylalanine metabolism;
 map00590  Prostaglandin and leukotriene metabolism;
 map00680  Methane metabolism;
 map00940  Stilbene, coumarine and lignin biosynthesis

# Metabolic_Enzyme_9_Reaction:
donor + H2O2 = oxidized donor + 2 H2O

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF03098:An_peroxidase

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 1.11.1.7

# Metabolic_Enzyme_9_GenBank_ID_Protein:
189040

# Metabolic_Enzyme_9_SwissProt_ID:
PERM_HUMAN (P05164)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
MPO

# Metabolic_Enzyme_9_Geneatlas_id:
MPO

# Metabolic_Enzyme_9_hgnc_id:
HGNC:7218

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_9_Gene_Sequence:
>2238 bp
ATGGGGGTTCCCTTCTTCTCTTCTCTCAGATGCATGGTGGACTTAGGACCTTGCTGGGCT
GGGGGTCTCACTGCAGAGATGAAGCTGCTTCTGGCCCTAGCAGGGCTCCTGGCCATTCTG
GCCACGCCCCAGCCCTCTGAAGGTGCTGCTCCAGCTGTCCTGGGGGAGGTGGACACCTCG
TTGGTGCTGAGCTCCATGGAGGAGGCCAAGCAGCTGGTGGACAAGGCCTACAAGGAGCGG
CGGGAAAGCATCAAGCAGCGGCTTCGCAGCGGCTCAGCCAGCCCCATGGAACTCCTATCC
TACTTCAAGCAGCCGGTGGCAGCCACCAGGACGGCGGTGAGGGCCGCTGACTACCTGCAC
GTGGCTCTAGACCTGCTGGAGAGGAAGCTGCGGTCCCTGTGGCGAAGGCCATTCAATGTC
ACTGATGTGCTGACGCCCGCCCAGCTGAATGTGTTGTCCAAGTCAAGCGGCTGCGCCTAC
CAGGACGTGGGGGTGACTTGCCCGGAGCAGGACAAATACCGCACCATCACCGGGATGTGC
AACAACAGACGCAGCCCCACGCTGGGGGCCTCCAACCGTGCCTTTGTGCGCTGGCTGCCG
GCGGAGTATGAGGACGGCTTCTCTCTTCCCTACGGCTGGACGCCCGGGGTCAAGCGCAAC
GGCTTCCCGGTGGCTCTGGCTCGCGCGGTCTCCAACGAGATCGTGCGCTTCCCCACTGAT
CAGCTGACTCCGGACCAGGAGCGCTCACTCATGTTCATGCAATGGGGCCAGCTGTTGGAC
CACGACCTCGACTTCACCCCTGAGCCGGCCGCCCGGGCCTCCTTCGTCACTGGCGTCAAC
TGCGAGACCAGCTGCGTTCAGCAGCCGCCCTGCTTCCCGCTCAAGATCCCGCCCAATGAC
CCCCGCATCAAGAACCAAGCCGACTGCATCCCGTTCTTCCGCTCCTGCCCGGCTTGCCCC
GGGAGCAACATCACCATCCGCAACCAGATCAACGCGCTCACTTCCTTCGTGGACGCCAGC
ATGGTGTACGGCAGCGAGGAGCCCCTGGCCAGGAACCTGCGCAACATGTCCAACCAGCTG
GGGCTGCTGGCCGTCAACCAGCGCTTCCAAGACAACGGCCGGGCCCTGCTGCCCTTTGAC
AACCTGCACGATGACCCCTGTCTCCTCACCAACCGCTCAGCGCGCATCCCCTGCTTCCTG
GCAGGGGACACCCGTTCCAGTGAGATGCCCGAGCTCACCTCCATGCACACCCTCTTACTT
CGGGAGCACAACCGGCTGGCCACAGAGCTCAAGAGCCTGAACCCTAGGTGGGATGGGGAG
AGGCTCTACCAGGAAGCCCGGAAGATCGTGGGGGCCATGGTCCAGATCATCACTTACCGG
GACTACCTGCCCCTGGTGCTGGGGCCAACGGCCATGAGGAAGTACCTGCCCACGTACCGT
TCCTACAATGACTCAGTGGACCCACGCATCGCCAACGTCTTCACCAATGCCTTCCGCTAC
GGCCACACCCTCATCCAACCCTTCATGTTCCGCCTGGACAATCGGTACCAGCCCATGGAA
CCCAACCCCCGTGTCCCCCTCAGCAGGGTCTTTTTTGCCTCCTGGAGGGTCGTGCTGGAA
GGTGGCATTGACCCCATCCTCCGGGGCCTCATGGCCACCCCTGCCAAGCTGAATCGTCAG
AACCAAATTGCAGTGGATGAGATCCGGGAGCGATTGTTTGAGCAGGTCATGAGGATTGGG
CTGGACCTGCCTGCTCTGAACATGCAGCGCAGCAGGGACCACGGCCTCCCAGGATACAAT
GCCTGGAGGCGCTTCTGTGGGCTCCCGCAGCCTGAAACTGTGGGCCAGCTGGGCACGGTG
CTGAGGAACCTGAAATTGGCGAGGAAACTGATGGAGCAGTATGGCACGCCCAACAACATC
GACATCTGGATGGGCGGCGTGTCCGAGCCTCTGAAGCGCAAAGGCCGCGTGGGCCCACTC
CTCGCCTGCATCATCGGTACCCAGTTCAGGAAGCTCCGGGATGGTGATCGGTTTTGGTGG
GAGAACGAGGGTGTGTTCAGCATGCAGCAGCGACAGGCCCTGGCCCAGATCTCATTGCCC
CGGATCATCTGCGACAACACAGGCATCACCACCGTGTCTAAGAACAACATCTTCATGTCC
AACTCATATCCCCGGGACTTTGTCAACTGCAGTACACTTCCTGCATTGAACCTGGCTTCC
TGGAGGGAAGCCTCCTAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
J02694

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_9_Locus:
17q23.1

# Metabolic_Enzyme_9_SNPs:
rs7208693; rs2759; rs28730835; rs35314437; rs34628871; rs6503857; rs2856857; rs28396732; rs2071409; rs8067377; rs8082134; rs34506259; rs34704261; rs35921530; rs35840794; rs34028830; rs35087219; rs34376256; rs34212101; rs35400724; rs35112109; rs11575868; rs34471705; rs34914394; rs34673822; rs11649901; rs916115; rs35709273; rs7220117; rs8079006; rs2243828; rs2107545; rs2243827; rs8178426; rs2333227; rs12601419; rs34539862; rs34070619; rs34097845; rs34565045; rs8178428; rs35702888; rs35670089; rs2856856; rs28730837; rs35755750; rs2856855; rs35897051; rs35352616; rs8073898; rs11555567; rs34738107; rs11575867; rs2856859; rs2856858; rs2526363; rs11489012; rs2526362; rs2856852; rs34108145; rs28730838; rs11489013; rs2526364; rs12939070; rs34646152; rs12939069; rs11659055; rs34496983; rs36015586; rs35966215; rs35550002; rs36000892; rs35977697; rs2856864; rs34802326; rs8081735; rs2856861; rs11272526; rs34685535; rs2107546; rs34151601; rs36049426; rs916116; rs2526366; rs34341256; rs35614168; rs2856863; rs2856860; rs2526365; rs35830722; rs35286509; rs34841676; rs2856865; rs35922881; rs35369873; rs34432014; rs34576380; rs8178425; rs35412618; rs35433825; rs34240282; rs916114; rs34534274; rs2856854; rs34721594; rs35619750; rs8178429; rs2856853; rs8178424; rs8178427; rs34626646; rs11650865; rs12452417; rs12453852; rs12949848; rs16942910; rs2856862; rs34853811; rs3744104; rs4401102; rs8178373; rs8178375; rs8178378; rs8178380; rs8178381; rs8178384; rs8178386; rs8178387; rs8178392; rs8178395; rs8178398; rs8178404; rs8178405; rs8178406; rs8178407; rs8178409; rs8178410; rs8178412; rs8178415; rs8178416; rs8178417; rs8178418

# Metabolic_Enzyme_9_General_References:
3029127; 2444596; 3031585; 2552418; 3654979; 2903767; 8383257; 8390465; 2884926; 2154223; 10766826; 7840679; 11705390; 8142659; 7904599; 8621627; 9637725; 9354683

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5515

# Metabolic_Enzyme_10_Name:
Aspartate aminotransferase, cytoplasmic

# Metabolic_Enzyme_10_Synonyms:
Transaminase A; Glutamate oxaloacetate transaminase 1

# Metabolic_Enzyme_10_Gene_Name:
GOT1

# Metabolic_Enzyme_10_Protein_Sequence:
>Aspartate aminotransferase, cytoplasmic
MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQK
IANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFL
ARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLEN
APEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWA
IRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPP
AQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGM
FSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ

# Metabolic_Enzyme_10_Number_of_Residues:
413

# Metabolic_Enzyme_10_Molecular_Weight:
46248

# Metabolic_Enzyme_10_Theoretical_pI:
7.01

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  transaminase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_10_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00272  Cysteine metabolism;
 map00330  Arginine and proline metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00401  Novobiocin biosynthesis;
 map00710  Carbon fixation;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_10_Reaction:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.6.1.1

# Metabolic_Enzyme_10_GenBank_ID_Protein:
179067

# Metabolic_Enzyme_10_SwissProt_ID:
AATC_HUMAN (P17174)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
GOT1

# Metabolic_Enzyme_10_Geneatlas_id:
GOT1

# Metabolic_Enzyme_10_hgnc_id:
HGNC:4432

# Metabolic_Enzyme_10_PDB_ID:
1AJS

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_10_Gene_Sequence:
>1242 bp
ATGGCACCTCCGTCAGTCTTTGCCGAGGTTCCGCAGGCCCAGCCTGTCCTGGTCTTCAAG
CTCACTGCCGACTTCAGGGAGGATCCGGACCCCCGCAAGGTCAACCTGGGAGTGGGAGCA
TATCGCACGGATGACTGCCATCCCTGGGTTTTGCCAGTAGTGAAGAAAGTGGAGCAGAAG
ATTGCTAATGACAATAGCCTAAATCACGAGTATCTGCCAATCCTGGGCCTGGCTGAGTTC
CGGAGCTGTGCTTCTCGTCTTGCCCTTGGGGATGACAGCCCAGCACTCAAGGAGAAGCGG
GTAGGAGGTGTGCAATCTTTGGGGGGAACAGGTGCACTTCGAATTGGAGCTGATTTCTTA
GCGCGTTGGTACAATGGAACAAACAACAAGAACACACCTGTCTATGTGTCCTCACCAACC
TGGGAGAATCACAATGCTGTGTTTTCCGCTGCTGGTTTTAAAGACATTCGGTCCTATCGC
TACTGGGATGCAGAGAAGAGAGGATTGGACCTCCAGGGCTTCCTGAATGATCTGGAGAAT
GCTCCTGAGTTCTCCATTGTTGTCCTCCACGCCTGTGCACACAACCCAACTGGGATTGAC
CCAACTCCGGAGCAGTGGAAGCAGATTGCTTCTGTCATGAAGCACCGGTTTCTGTTCCCC
TTCTTTGACTCAGCCTATCAGGGCTTCGCATCTGGAAACCTGGAGAGAGATGCCTGGGCC
ATTCGCTATTTTGTGTCTGAAGGCTTCGAGTTCTTCTGTGCCCAGTCCTTCTCCAAGAAC
TTCGGGCTCTACAATGAGAGAGTCGGGAATCTGACTGTGGTTGGAAAAGAACCTGAGAGC
ATCCTGCAAGTCCTTTCCCAGATGGAGAAGATCGTGCGGATTACTTGGTCCAATCCCCCC
GCCCAGGGAGCACGAATTGTGGCCAGCACCCTCTCTAACCCTGAGCTCTTTGAGGAATGG
ACAGGTAATGTGAAGACAATGGCTGACCGGATTCTGACCATGAGATCTGAACTCAGGGCA
CGACTAGAAGCCCTCAAAACCCCTGGGACCTGGAACCACATCACTGATCAAATTGGCATG
TTCAGCTTCACTGGGTTGAACCCCAAGCAGGTTGAGTATCTGGTCAATGAAAAGCACATC
TACCTGCTGCCAAGTGGTCGAATCAACGTGAGTGGCTTAACCACCAAAAATCTAGATTAC
GTGGCCACCTCCATCCATGAAGCAGTCACCAAAATCCAGTGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
M37400

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_10_Locus:
10q24.1-q25.1

# Metabolic_Enzyme_10_SNPs:
rs2234971; rs2641; rs11867; rs1126878; rs11190083; rs2862611; rs4328160; rs4919310; rs11813054; rs3793935; rs4919308; rs17111658; rs3750897; rs2275952; rs7906501; rs7918062; rs7067702; rs9971275; rs9971274; rs11190087; rs11594790; rs12571181; rs12249347; rs10883343; rs11819158; rs4353208; rs3763793; rs11190088; rs17569447; rs3793933; rs7921465; rs12253915; rs3793934; rs2494651; rs10883341; rs2862612; rs2490280; rs12768505; rs17111665; rs2862613; rs17569578; rs4567385; rs11815136; rs10883342; rs10748775; rs4919309; rs17491012; rs12253861; rs11190081; rs2862614; rs12217584; rs11815637; rs12766044; rs17111645; rs17111694; rs4919311; rs12411568; rs11557841; rs4564264; rs41290500; rs11557840; rs1126927; rs11190082; rs2642; rs1802509; rs1802508; rs41290498; rs34854950; rs12777843; rs35687189; rs11394746; rs34971146; rs34646712; rs35478605; rs34582301; rs3045656; rs12252840; rs35736782; rs11378738; rs7918037; rs41400447; rs7896693; rs5787336; rs9731375; rs35003844; rs11456562; rs11313874; rs12358477; rs10668892; rs12241455; rs41436049; rs5787337; rs9971276; rs35500142; rs35096443; rs11456561; rs2902275; rs7899976; rs13377085; rs12777646; rs10629267; rs12414885; rs35193236; rs11325628; rs12777641; rs34254460; rs1892505; rs12776735; rs12776369; rs4917866; rs12775973; rs11816599; rs6584274; rs33928164; rs10786543; rs7917808; rs11429814; rs35546038; rs10716499; rs35665184; rs11190090; rs34122561; rs2234894; rs10748774; rs10786545; rs11190080; rs11190094; rs1132364; rs11592057; rs11598504; rs17111699; rs17490682; rs2298315; rs2298316; rs2490281; rs2490283; rs2494652; rs2494653; rs2494654; rs2862610; rs34183428; rs3750896; rs3793931; rs3793932; rs4345898; rs4917862; rs4917864; rs4919307; rs7099391; rs7914408; rs7920356

# Metabolic_Enzyme_10_General_References:
1974457; 2241899

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5516

# Metabolic_Enzyme_11_Name:
Aspartate aminotransferase, mitochondrial precursor

# Metabolic_Enzyme_11_Synonyms:
Transaminase A; Glutamate oxaloacetate transaminase 2

# Metabolic_Enzyme_11_Gene_Name:
GOT2

# Metabolic_Enzyme_11_Protein_Sequence:
>Aspartate aminotransferase, mitochondrial precursor
MALLHSGRVLPGIAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEAFKRDTNSKKM
NLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENSEV
LKSGRFVTVQTISGTGALRIGASFLQRFFKFSRDVFLPKPTWGNHTPIFRDAGMQLQGYR
YYDPKTCGFDFTGAVEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIATVVKKRNLFA
FFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTMVCKDADE
AKRVESQLKILIRPMYSNPPLNGARIAAAILNTPDLRKQWLQEVKGMADRIIGMRTQLVS
NLKKEGSTHNWQHITDQIGMFCFTGLKPEQVERLIKEFSIYMTKDGRISVAGVTSSNVGY
LAHAIHQVTK

# Metabolic_Enzyme_11_Number_of_Residues:
430

# Metabolic_Enzyme_11_Molecular_Weight:
47476

# Metabolic_Enzyme_11_Theoretical_pI:
9.38

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  transaminase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_11_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00272  Cysteine metabolism;
 map00330  Arginine and proline metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00401  Novobiocin biosynthesis;
 map00710  Carbon fixation;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_11_Reaction:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_11_Signals:
1-24

# Metabolic_Enzyme_11_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.6.1.1

# Metabolic_Enzyme_11_GenBank_ID_Protein:
179104

# Metabolic_Enzyme_11_SwissProt_ID:
AATM_HUMAN (P00505)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
GOT2

# Metabolic_Enzyme_11_Geneatlas_id:
GOT2

# Metabolic_Enzyme_11_hgnc_id:
HGNC:4433

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_11_Gene_Sequence:
>1293 bp
ATGGCCCTGCTGCACTCCGGCCGCGTCCTCCCCGGGATCGCCGCCGCCTTCCACCCGGGC
CTCGCCGCCGCGGCCTCTGCCAGAGCCAGCTCCTGGTGGACCCATGTGGAAATGGGACCT
CCAGATCCCATTCTGGGAGTCACTGAAGCCTTTAAGAGGGACACCAATAGCAAAAAGATG
AATCTGGGAGTTGGTGCCTACCGGGATGATAATGGAAAGCCTTACGTTCTGCCTAGCGTC
CGCAAGGCAGAGGCCCAGATTGCCGCAAAAAATTTGGACAAGGAATACCTGCCCATTGGG
GGACTGGCTGAATTTTGCAAGGCATCTGCAGAACTAGCCCTGGGTGAGAACAGCGAAGTC
TTGAAGAGTGGCCGGTTTGTCACTGTGCAGACCATTTCTGGAACTGGAGCCTTAAGGATC
GGAGCCAGTTTTCTGCAAAGATTTTTTAAGTTCAGCCGAGATGTCTTTCTGCCCAAACCA
ACCTGGGGAAACCACACACCCATCTTCAGGGATGCTGGCATGCAGCTACAAGGTTATCGG
TATTATGACCCCAAGACTTGCGGTTTTGACTTCACAGGCGCTGTGGAGGATATTTCAAAA
ATACCAGAGCAGAGTGTTCTTCTTCTGCATGCCTGCGCCCACAATCCCACGGGAGTGGAC
CCGCGTCCGGAACAGTGGAAGGAAATAGCAACAGTGGTGAAGAAAAGGAATCTCTTTGCG
TTCTTTGACATGGCCTACCAAGGCTTTGCCAGTGGTGATGGTGATAAGGATGCCTGGGCT
GTGCGCCACTTCATCGAACAGGGCATTAATGTTTGCCTCTGCCAATCATATGCCAAGAAC
ATGGGCTTATATGGTGAGCGTGTAGGAGCCTTCACTATGGTCTGCAAAGATGCGGATGAA
GCCAAAAGGGTAGAGTCACAGTTGAAGATCTTGATCCGTCCCATGTATTCCAACCCTCCC
CTCAATGGGGCCCGGATTGCTGCTGCCATTCTGAACACCCCAGATTTGCGAAAACAATGG
CTGCAAGAAGTGAAAGGCATGGCTGACCGCATCATTGGCATGCGGACTCAACTGGTCTCC
AACCTCAAGAAGGAGGGTTCCACCCACAATTGGCAACACATCACCGACCAAATTGGCATG
TTCTGTTTCACAGGGCTAAAGCCTGAACAGGTGGAGCGGCTGATCAAGGAGTTCTCCATC
TACATGACAAAAGATGGCCGCATCTCTGTGGCAGGGGTCACCTCCAGCAACGTGGGCTAC
CTTGCCCATGCCATTCACCAGGTCACCAAGTAA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
M22632

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_11_Locus:
16q21

# Metabolic_Enzyme_11_SNPs:
rs30842; rs11076256; rs257636; rs6993; rs7202491; rs11861897; rs257620; rs863944; rs6499971; rs30838; rs30839; rs7204324; rs257616; rs257630; rs1646256; rs8060056; rs6499970; rs30834; rs257617; rs185397; rs257634; rs12600277; rs257618; rs2304490; rs7196291; rs30837; rs9921563; rs1610878; rs4784975; rs9926132; rs257637; rs1646267; rs257631; rs13334922; rs1424245; rs30836; rs190473; rs257633; rs7186087; rs30835; rs173992; rs10500407; rs257649; rs187277; rs9926863; rs40574; rs183757; rs30843; rs1657179; rs7189519; rs1657178; rs2042445; rs7188608; rs257650; rs1803169; rs17849335; rs11558171; rs8059441; rs1058192; rs14221; rs11558167; rs1803168; rs28612351; rs3208672; rs1803170; rs7186105; rs35645687; rs5817158; rs11333258; rs34912264; rs10676089; rs1436429; rs35946557; rs4784974; rs8047219; rs12922626; rs34509416; rs257632; rs35502495; rs12919184; rs7184964; rs9934653; rs9921588; rs4784976; rs13334281; rs9921474; rs12597424; rs7185829; rs13330819; rs28497727; rs34526718; rs7204346; rs3217426; rs11348341; rs34853918; rs257621; rs30840; rs34039790; rs35247174; rs13337034; rs34792826; rs171786; rs30841; rs1657182; rs34180921; rs9923914; rs12921667; rs12933313; rs11299978; rs8046165; rs35323432; rs11423426; rs12932751; rs9933525; rs7186806; rs34289635; rs35324915; rs11439864; rs8046634; rs40575; rs11445492; rs28463297; rs5817159; rs35679170; rs34405351; rs9927670; rs257619; rs35298154; rs3743573; rs8045857; rs9933114; rs8044891; rs35125089; rs35939343; rs7187269; rs257638; rs7194323; rs12923759; rs28472773; rs839418; rs35327432; rs7189104; rs4273028; rs7199783; rs1646260; rs10563758; rs11643959; rs11644269; rs11644290; rs11647748; rs11647808; rs11859875; rs1473205; rs1473206; rs154435; rs1616798; rs1646268; rs3931747; rs4238801; rs4784054; rs4784977; rs6499969; rs7195214; rs7197245

# Metabolic_Enzyme_11_General_References:
3207426; 4052435

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5517

# Metabolic_Enzyme_12_Name:
Eosinophil peroxidase precursor

# Metabolic_Enzyme_12_Synonyms:
EPO[Contains: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain]

# Metabolic_Enzyme_12_Gene_Name:
EPX

# Metabolic_Enzyme_12_Protein_Sequence:
>Eosinophil peroxidase precursor
MHLLPALAGVLATLVLAQPCEGTDPASPGAVETSVLRDCIAEAKLLVDAAYNWTQKSIKQ
RLRSGSASPMDLLSYFKQPVAATRTVVRAADYMHVALGLLEEKLQPQRSGPFNVTDVLTE
PQLRLLSQASGCALRDQAERCSDKYRTITGRCNNKRRPLLGASNQALARWLPAEYEDGLS
LPFGWTPSRRRNGFLLPLVRAVSNQIVRFPNERLTSDRGRALMFMQWGQFIDHDLDFSPE
SPARVAFTAGVDCERTCAQLPPCFPIKIPPNDPRIKNQRDCIPFFRSAPSCPQNKNRVRN
QINALTSFVDASMVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGRALLPFDNLHDDPCL
LTNRSARIPCFLAGDTRSTETPKLAAMHTLFMREHNRLATELRRLNPRWNGDKLYNEARK
IMGAMVQIITYRDFLPLVLGKARARRTLGHYRGYCSNVDPRVANVFTLAFRFGHTMLQPF
MFRLDSQYRASAPNSHVPLSSAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDEL
RDRLFRQVRRIGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLAR
KFLNLYGTPDNIDIWIGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWWQKRGVFTK
RQRKALSRISLSRIICDNTGITTVSRDIFRANIYPRGFVNCSRIPRLNLSAWRGT

# Metabolic_Enzyme_12_Number_of_Residues:
715

# Metabolic_Enzyme_12_Molecular_Weight:
81042

# Metabolic_Enzyme_12_Theoretical_pI:
10.81

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Not Available

# Metabolic_Enzyme_12_Specific_Function:
Donor + H(2)O(2) = oxidized donor + 2 H(2)O

# Metabolic_Enzyme_12_Pathway:
map00360  Phenylalanine metabolism;
 map00590  Prostaglandin and leukotriene metabolism;
 map00680  Methane metabolism;
 map00940  Stilbene, coumarine and lignin biosynthesis

# Metabolic_Enzyme_12_Reaction:
donor + H2O2 = oxidized donor + 2 H2O

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF03098:An_peroxidase

# Metabolic_Enzyme_12_Signals:
1-17

# Metabolic_Enzyme_12_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 1.11.1.7

# Metabolic_Enzyme_12_GenBank_ID_Protein:
182146

# Metabolic_Enzyme_12_SwissProt_ID:
PERE_HUMAN (P11678)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
EPX

# Metabolic_Enzyme_12_Geneatlas_id:
EPX

# Metabolic_Enzyme_12_hgnc_id:
HGNC:3423

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils

# Metabolic_Enzyme_12_Gene_Sequence:
>2148 bp
ATGCATCTGCTCCCAGCCCTGGCAGGGGTCCTGGCCACACTCGTCCTCGCCCAGCCCTGT
GAGGGCACTGACCCAGCCTCCCCTGGGGCAGTGGAGACCTCGGTCCTGCGAGACTGCATA
GCAGAGGCCAAGTTGCTGGTGGATGCTGCCTACAATTGGACCCAGAAGAGCATCAAGCAG
CGGCTTCGCAGCGGTTCAGCCAGCCCCATGGACCTCCTGTCCTACTTCAAACAACCGGTA
GCAGCCACCAGGACAGTTGTTCGGGCCGCAGATTATATGCATGTGGCTTTGGGGCTGCTT
GAAGAGAAGTTACAACCCCAGCGGTCCGGACCCTTCAATGTCACTGATGTGCTAACAGAA
CCACAGCTGCGGCTGCTGTCCCAGGCCAGTGGCTGTGCTCTCCGGGACCAGGCCGAGCGC
TGCAGCGACAAGTACCGCACCATCACTGGACGGTGCAACAACAAGAGGAGACCCTTGCTA
GGGGCCTCCAACCAGGCTCTGGCTCGCTGGCTGCCCGCCGAGTATGAGGATGGGCTGTCG
CTCCCCTTCGGCTGGACCCCCAGCAGGAGGCGCAATGGCTTCCTTCTCCCTCTTGTCCGG
GCTGTCTCCAACCAGATTGTGCGCTTCCCCAATGAGAGACTGACCTCCGACCGTGGCCGA
GCCCTCATGTTCATGCAGTGGGGCCAGTTCATTGACCATGACCTGGACTTCTCCCCGGAG
TCCCCGGCCAGAGTGGCCTTCACTGCAGGCGTTGACTGTGAGAGGACCTGCGCCCAGCTG
CCCCCCTGCTTTCCCATCAAGATCCCACCCAATGACCCCCGCATCAAGAACCAGCGTGAC
TGCATCCCTTTCTTCCGCTCGGCACCCTCATGCCCCCAAAACAAGAACAGAGTCCGCAAC
CAGATCAACGCGCTCACCTCCTTTGTGGACGCCAGCATGGTGTATGGCAGTGAGGTCTCC
CTCTCGCTGCGGCTCCGCAACCGGACCAACTACCTGGGGCTGCTGGCCATCAACCAGCGC
TTTCAAGACAACGGCCGGGCCCTGCTGCCCTTCGACAACCTGCACGATGACCCCTGTCTC
CTCACCAACCGCTCGGCGCGCATCCCCTGCTTCCTGGCAGGTGACACCCGATCAACGGAA
ACCCCCAAACTGGCAGCCATGCACACCCTCTTTATGCGAGAGCACAACCGGCTGGCCACC
GAGCTGAGACGCCTGAATCCCCGGTGGAATGGAGACAAACTGTACAATGAGGCTCGGAAG
ATCATGGGGGCCATGGTCCAGATCATCACCTACCGAGACTTTCTGCCCCTGGTTCTGGGC
AAGGCCCGGGCCAGGAGAACCCTGGGGCACTACAGGGGGTACTGCTCCAATGTGGACCCA
CGGGTGGCCAATGTCTTCACCCTGGCCTTCCGCTTTGGCCACACAATGCTCCAGCCCTTC
ATGTTCCGCTTGGACAGTCAGTACCGGGCCTCCGCACCCAACTCGCATGTCCCACTTAGC
TCTGCCTTCTTTGCCAGCTGGCGGATCGTGTATGAAGGGGGCATCGACCCCATCCTCCGG
GGCCTCATGGCCACCCCTGCCAAGCTGAACCGTCAGGATGCCATGTTAGTGGATGAGCTC
CGGGACCGGCTGTTTCGGCAAGTGAGGAGGATTGGGCTGGACCTGGCAGCTCTCAACATG
CAACGAAGCCGGGACCACGGCCTTCCAGGGTACAATGCTTGGAGGCGCTTCTGTGGGCTC
TCCCAGCCCCGGAATTTGGCACAGCTTAGCCGGGTGCTGAAAAACCAGGACTTGGCAAGG
AAGTTCCTGAATTTGTATGGAACACCTGACAACATTGACATCTGGATTGGGGCCATCGCT
GAGCCTCTTTTGCCGGGGGCTCGAGTGGGGCCTCTTCTGGCTTGTCTGTTCGAGAACCAG
TTCAGAAGAGCCCGAGACGGAGACAGGTTCTGGTGGCAGAAACGAGGTGTTTTCACCAAA
AGACAGCGCAAGGCCCTGAGCAGAATTTCCTTGTCTCGAATTATATGTGACAATACCGGT
ATCACCACGGTTTCAAGGGACATCTTCAGAGCCAACATCTACCCTCGGGGCTTTGTGAAC
TGCAGCCGTATCCCCAGGTTGAACCTATCAGCCTGGCGAGGGACATGA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
M29913

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_12_Locus:
17q23.1

# Metabolic_Enzyme_12_SNPs:
rs11079339; rs2302311; rs11652709; rs33971258; rs33955150; rs35135976; rs34817773; rs34553736; rs35750729; rs35617692; rs2240815; rs33979458; rs35979397; rs34607215; rs35419219; rs34599426; rs12602891; rs35844881; rs11079340; rs9892223; rs8077426; rs10853004; rs12602498; rs35620058; rs16942821; rs3785496; rs17222131; rs34415223; rs34489936; rs34621939; rs34467121; rs35601356; rs34225527; rs35892171; rs34409274; rs35700737; rs34630438; rs35005272; rs36066186; rs35706110; rs34137093; rs35352002; rs34630974; rs34421287; rs36098226; rs34139955; rs35974634; rs34270809; rs35223829; rs35707074; rs35219654; rs33954589; rs35212966; rs35209704; rs34212868; rs34898935; rs7224829; rs9891461; rs34102213; rs9895340; rs35074452; rs35832094; rs35896669; rs35232062; rs34883182; rs3922310; rs34444359; rs35584824; rs34519902; rs34433459; rs3785495; rs41561914; rs34021481; rs35062441; rs34704928; rs33963229; rs2333143; rs34555545; rs8078707; rs35755602; rs34441210; rs12952084; rs35552012; rs36011493; rs34390300; rs34570969; rs35143529; rs34209988; rs35036774; rs34141323; rs7222982; rs41544715; rs41558615; rs34820204; rs34999393; rs34554286; rs12947423; rs41541513; rs3760170; rs35722136; rs34702287; rs34690449; rs1045619; rs11548967; rs12103876; rs16942800; rs16942826; rs16942829; rs2191243; rs2191244; rs2302312; rs2302313; rs3213698; rs34560289; rs34631184; rs35184412; rs35464956; rs3744105; rs3760171; rs3785494; rs3826300; rs6503851; rs6503852; rs7210200; rs8067411; rs8067752; rs8068965; rs8071411; rs917606; rs9901765; rs9902640; rs9906421; rs9913536; rs9915578

# Metabolic_Enzyme_12_General_References:
2550461; 2541222; 10358043; 7809065

# Metabolic_Enzyme_12_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8531

# Macromolecular_Interacting_Partner_1_Name:
Low-affinity cationic amino acid transporter 2

# Macromolecular_Interacting_Partner_1_Synonyms:
CAT-2; CAT2

# Macromolecular_Interacting_Partner_1_Gene_Name:
SLC7A2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Lowaffinity cationic amino acid transporter 2
MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA
KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI
LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLL
SFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENG
TSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCF
MAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPM
PRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLM
AYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLF
CPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAI
VLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFS
YGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
658

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
71674

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.31

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
 Function:  amino acid permease activity
Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
 Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_1_Specific_Function:
Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine)

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_1_Signals:
1-543

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
38-59
64-84
105-125
164-184
193-213
249-269
290-309
340-360
387-407
411-431
491-511
525-549
558-578
583-603

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
849051

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
CTR2_HUMAN (P52569)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
SLC7A2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
SLC7A2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:11060

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1977 bp
ATGATTCCTTGCAGAGCCGCGCTGACCTTTGCCCGATGTCTGATCCGGAGAAAAATCGTG
ACCCTGGACAGTCTAGAAGACACCAAATTATGCCGCTGCTTATCCACCATGGACCTCATT
GCCCTGGGCGTTGGAAGCACCCTTGGGGCCGGGGTTTATGTCCTCGCTGGGGAGGTGGCC
AAGGCAGACTCGGGCCCCAGCATCGTGGTGTCCTTCCTCATTGCTGCCCTGGCTTCAGTG
ATGGCTGGCCTCTGCTATGCCGAATTTGGGGCCCGTGTTCCCAAGACGGGGTCTGCATAT
TTGTACACCTACGTGACTGTCGGAGAGCTGTGGGCCTTCATCACTGGCTGGAATCTCATT
TTATCGTATGTGATAGGTACATCAAGTGTTGCAAGAGCCGGGAGTGGCACCTTTGATGAA
CTTCTTAGCAAACAGATTGGTCAGTTTTTGAGGACATACTTCAGAATGAATTACACTGGT
CTTGCAGAATATCCCGATTTTTTTGCTGTGTGCCTTATATTACTTCTAGCAGGTCTTTTG
TCTTTTGGAGTAAAAGAGTCTGCTTGGGTGAATAAAGTCTTCACAGCTGTTAATATTCTC
GTCCTTCTGTTTGTGATGGTTGCTGGGTTTGTGAAAGGAAATGTGGCAAACTGGAAGATT
AGTGAAGAGTTTCTCAAAAATATATCAGCAAGTGCCAGAGAGCCACCTTCTGAAAACGGA
ACAAGTATCTATGGGGCTGGTGGCTTTATGCCTTATGGCTTTACGGGAACGTTGGCTGGT
GCTGCAACTTGCTTTTATGCCTTTGTGGGATTTGACTGCATTGCAACAACTGGTGAAGAA
GTTCGGAATCCCCAGAAAGCTATTCCCATTGGAATTGTGACGTCTTTGCTTGTTTGCTTT
ATGGCCTATTTTGGGGTCTCTGCAGCTTTAACACTTATGATGCCGTACTACCTCCTCGAT
GAAAAAAGCCCCCTTCCTGTAGCGTTTGAATATGTGGGATGGGGTCCTGCCAAATATGTC
GTCGCAGCTGGTTCTCTCTGCGCCTTGTCAACAAGTCTTCTTGGATCCATTTTCCCAATG
CCTCGTGTAAACTATGCTATGGCGGAGGATGGGTTGCTTTTCAAATGTCTAGCTCAAATC
AATTCCAAAACGAAGACACCAATAATTGCTACTTTATCATCGGGTGCAGTGGCAGCTTTG
ATGGCCTTTCTGTTTGACCTGAAGGCGCTTGTGGACATGATGTCCATTGGCACACTCATG
GCCTACTCTCTGGTGGCAGCCTGTGTTCTCATCCTCAGGTACCAGCCTGGCTTATCTTAC
GACCAGCCCAAATGTTCTCCTGAGAAAGATGGTCTGGGATCGTCTCCCAGGGTAACCTCG
AAGAGTGAGTCCCAGGTCACCATGCTGCAGAGACAGGGCTTCAGCATGCGGACCCTCTTC
TGCCCCTCCCTTCTGCCAACACAGCAGTCAGCTTCTCTCGTGAGCTTTCTGGTAGGATTC
CTAGCTTTCCTCGTGTTGGGCCTGAGTGTCTTGACCACTTACGGAGTTCATGCCATCTAC
AGGCTGGAGGCCTGGAGCCTCGCTCTCCTCGCGCTGTTTCTTGTTCTCTTCGTTGCCATC
GTTCTCACCATCTGGAGGCAGCCCCAGAATCAACGAAAAGTAGCCTTCATGGTTCCATTC
TTACCATTTTTGCCGACGTTCACGATCTTGGTGAACATTTACTTGATGGTCCAGTTAAGT
GCAGACACTTGGGTCAGATTCAGCATTTGGATGGCAATTGGCTTCCTGATTTACTTTTCT
TATGGCATTAGACACAGCCTGGAGGGTCATCTGAGAGATGAAAACAATGAAGAAGATGCT
TATCCAGACAACGTTCATGCAGCAGCAGAAGAAAAATCTGCCATTCAAGCAAATGACCAT
CACCCAAGAAATCTCAGTTCACCTTTCATATTCCATGAAAAGACAAGTGAATTCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
D29990

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:8

# Macromolecular_Interacting_Partner_1_Locus:
8p22-p21.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs12680645; rs1134975; rs2517250; rs2299564; rs7838611; rs13259948; rs2285294; rs7842456; rs10093732; rs4921783; rs11987107; rs2285295; rs2517251; rs959426; rs2237817; rs3739416; rs956776; rs7827805; rs7842267; rs6586610; rs7014645; rs7822703; rs7842109; rs13275006; rs6980566; rs6998037; rs6983122; rs7842106; rs6991730; rs7823792; rs13281010; rs17124788; rs13282723; rs17124794; rs2705017; rs13398; rs2588241; rs13259978; rs2299566; rs11991148; rs13281204; rs14108; rs2299565; rs17504840; rs6999536; rs6998033; rs6982176; rs6998481; rs12156195; rs2301539; rs2588250; rs2720588; rs737039; rs2720590; rs3780121; rs2588252; rs2245491; rs2427721; rs2705062; rs10105500; rs2705018; rs2720559; rs6994712; rs2517254; rs2517257; rs2588248; rs2285293; rs2245492; rs2720558; rs10503597; rs2705061; rs17124818; rs2588247; rs2517252; rs2588243; rs2705019; rs6586609; rs17124823; rs17124830; rs10100359; rs17124809; rs2248010; rs17504917; rs11998060; rs2015840; rs10107764; rs17632706; rs2517253; rs17124843; rs7000018; rs2244738; rs2245183; rs17124835; rs6981597; rs2705065; rs9644582; rs2301540; rs2299567; rs11986520; rs2588246; rs17632632; rs11993109; rs7002951; rs17124783; rs17124778; rs2006214; rs17124777; rs6982625; rs885642; rs1134973; rs1804759; rs1981498; rs1134972; rs1134976; rs1134977; rs1134974; rs35978538; rs12156191; rs7826955; rs34780401; rs34068374; rs13271221; rs12155892; rs11427242; rs3959114; rs13275900; rs35741414; rs34091134; rs12156132; rs12155849; rs6980866; rs2248862; rs12156021; rs2237818; rs13280567; rs35506586; rs28615154; rs15239; rs28523587; rs34047096; rs3178072; rs35210464; rs10500; rs28520866; rs2705021; rs28573094; rs6991561; rs3173997; rs7827073; rs2427722; rs10645883; rs13253724; rs10112024; rs2588174; rs35923193; rs2588256; rs35409598; rs10658350; rs17124844; rs35737396; rs35838638; rs2588253; rs13279058; rs35596928; rs11373033; rs11203869; rs2285292; rs35252224; rs35949792; rs7014136; rs2440550; rs35268822; rs2517256; rs34282373; rs17124840; rs7017409; rs34882479; rs34699482; rs2588173; rs13279050; rs34982645; rs10104505; rs6996683; rs11203871; rs2588251; rs2588254; rs2427723; rs10100029; rs9792322; rs11373918; rs10658349; rs2720557; rs2588255; rs2705020; rs10654963; rs2440548; rs12155782; rs10658348; rs35052068; rs35618187; rs10658351; rs6996690; rs7828462; rs6989698; rs10106650; rs9644556; rs2466175; rs6150488; rs34146412; rs11203870; rs35800296; rs36061161; rs34817373; rs34505484; rs36099091; rs10087373; rs2588239; rs28617533; rs2720551; rs7462798; rs2720553; rs7003239; rs28733060; rs3178073; rs34272503; rs34626771; rs28616245; rs34194871; rs1003403; rs12156216; rs12679616; rs13263776; rs13268741; rs13272153; rs17124775; rs17632601; rs2517242; rs2517244; rs2517245; rs2517246; rs2517248; rs2517261; rs2517262; rs2517263; rs2517264; rs2517265; rs2517266; rs2517267; rs2588163; rs2588164; rs2588166; rs2588167; rs2588168; rs2588169; rs2588222; rs2588223; rs2588225; rs2588226; rs2588228; rs2588229; rs2588230; rs2588232; rs2588233; rs2588234; rs2588235; rs2705051; rs2705052; rs2705053; rs2705054; rs2705073; rs2705074; rs2705084; rs2720498; rs2720499; rs2720574; rs2720575; rs2720576; rs3214085; rs3780116; rs3780117; rs7016764; rs9792388

# Macromolecular_Interacting_Partner_1_General_References:
8954799

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8594

# Macromolecular_Interacting_Partner_2_Name:
SLC38A2 protein

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
SLC38A2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>SLC38A2 protein
MKQNLILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIG
AMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGY
TSGLSLLCMVFFLIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDS
CRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYL
LAALFGYLTFYEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTH
LLCASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIK
LVKKEPMKSVQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
406

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
45180

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
8.88

# Macromolecular_Interacting_Partner_2_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_2_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_2_Signals:
1-18

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
5-23; 48-69; 89-111; 115-137; 230-252; 272-294; 315-334; 339-361; 373-395

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
Q6IA88_HUMAN (Q6IA88)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
SLC38A2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
SLC38A2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:13448

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
CR457267

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_2_Locus:
12q

# Macromolecular_Interacting_Partner_2_SNPs:
rs10880961; rs7968283; rs956910; rs2897968; rs7968173; rs7961994; rs10880959; rs2307063; rs1873793; rs3742061; rs2307061; rs10880960; rs3782904; rs7965930; rs2307062; rs2279559; rs7974529; rs7960147; rs10785624; rs11183450; rs34139863; rs36065261; rs36022751; rs11340856; rs7966787; rs11313787; rs5797976; rs1046296; rs11183449; rs12307969; rs2307060; rs36019260; rs3837525; rs35534621; rs11183447; rs3832874; rs3830356; rs34489723; rs36066221; rs11298796; rs7295472; rs35732850; rs35944767; rs34099989; rs10880962; rs11183446; rs12368989; rs1492896; rs17096884; rs4768697; rs4768698; rs7135630; rs7967840; rs7975820; rs7979418

# Macromolecular_Interacting_Partner_2_General_References:
Not Available

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8639

# Macromolecular_Interacting_Partner_3_Name:
L-type amino acid transporter 4

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC43A2

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Ltype amino acid transporter 4
MAPTLATAHRRRWWMACTAVLENLLFSAVLLGWGSLLIMLKSEGFYSYLCTEPENVTNGT
VGGTAEPGHEEVSWMNGWLSCQAQDEMLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRL
LGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSLTLPNMFGDLRSTFI
ALMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFFNWPLEPFPGPEDM
DYSVKIKFSWLGFDHKITGKQFYKQVTTVGRRLSVGSSMRSAKEQVALQEGHKLCLSTVD
LEVKCQPDAAVAPSFMHSVFSPILLLSLVTMCVTQLRLIFYMGAMNNILKFLVSGDQKTV
MATVGLYTSIFGVLQLLCLLTAPVIGYIMDWRLKECEDASEEPEEKDANQGEKKKKKRDR
QIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTIVRGFIHSAVGGLYAAVY
PSTQFGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLI
CYRRQLERQLQQRQEDDKLFLKINGSSNQEAFV

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
573

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
63150

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
8.00

# Macromolecular_Interacting_Partner_3_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF07690:MFS_1

# Macromolecular_Interacting_Partner_3_Signals:
1-32

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
20-39; 87-109; 118-135; 145-167; 179-201; 205-227; 323-345; 360-382; 426-448; 458-480; 487-509; 519-541

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
61287131

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
Q5CD75_HUMAN (Q5CD75)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC43A2

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC43A2

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:23087

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1722 bp
ATGGCGCCCACCCTGGCCACTGCCCATCGGCGCCGCTGGTGGATGGCCTGCACGGCCGTG
CTGGAGAACCTCCTCTTCTCGGCAGTCCTCCTGGGCTGGGGCTCGCTGCTCATCATGCTC
AAGTCAGAGGGCTTTTACTCCTACCTGTGTACCGAGCCAGAGAATGTCACCAATGGCACA
GTGGGCGGCACAGCAGAGCCGGGGCACGAGGAGGTGAGCTGGATGAACGGCTGGCTCAGC
TGCCAGGCCCAGGACGAGATGCTAAATTTGGCCTTCACTGTGGGCTCCTTTCTGCTCAGT
GCCATCACCCTGCCCCTGGGTATCGTCATGGACAAGTATGGCCCGAGGAAGCTCAGGCTG
CTGGGCAGCGCCTGCTTCGCGGTTTCCTGCTTGCTGATTGCGTACGGAGCAAGTAAACCA
AACGCTCTCTCCGTGCTCATCTTCATCGCCCTGGCTCTGAATGGCTTTGGTGGGATGTGT
ATGACCTTCACCTCATTAACACTGCCCAACATGTTCGGCGACCTTCGGTCCACGTTTATT
GCCTTGATGATTGGGTCCTACGCCTCCTCGGCAGTCACCTTTCCAGGAATCAAGCTCATC
TATGATGCTGGTGTCTCCTTCATCGTCGTCCTCGTGGTCTGGGCCGGCTGCTCCGGGCTG
GTTTTCCTCAACTGCTTCTTTAACTGGCCCCTTGAGCCCTTCCCGGGGCCGGAGGACATG
GACTACTCGGTGAAGATCAAGTTCAGCTGGCTGGGCTTTGACCACAAGATCACAGGGAAG
CAGTTCTACAAGCAGGTGACCACGGTGGGCCGGCGCCTGAGTGTGGGCAGCTCCATGAGG
AGTGCCAAGGAGCAGGTGGCGCTGCAGGAGGGCCACAAGCTGTGCCTGTCCACCGTCGAC
CTGGAGGTGAAGTGCCAGCCGGATGCCGCAGTGGCCCCCTCCTTCATGCACAGCGTGTTC
AGCCCCATCCTGCTGCTCAGCCTGGTCACCATGTGCGTCACGCAGCTGCGGCTCATCTTC
TACATGGGGGCTATGAACAACATCCTCAAGTTCCTGGTCAGCGGCGACCAGAAGACAGTG
ATGGCCACGGTTGGCCTCTACACCTCCATCTTCGGCGTGCTCCAGCTGCTGTGCCTGCTG
ACGGCCCCCGTCATTGGCTACATCATGGACTGGAGGCTGAAGGAGTGTGAAGACGCCTCC
GAGGAGCCCGAGGAGAAAGACGCCAACCAAGGCGAGAAGAAAAAGAAGAAGCGGGACCGG
CAGATCCAGAAGATCACTAATGCCATGCGGGCCTTCGCCTTCACCAACCTGCTGCTCGTG
GGCTTTGGGGTGACCTGCCTCATTCCCAACCTGCCTCTCCAGATCCTCTCCTTCATCCTG
CACACAATCGTGCGAGGATTCATCCACTCCGCTGTCGGGGGCCTGTACGCTGCCGTGTAC
CCCTCCACCCAGTTCGGCAGCCTCACGGGACTGCAGTCTCTGATCAGCGCGCTCTTCGCC
CTTCTGCAGCAGCCGCTGTTTCTGGCCATGATGGGTCCTCTCCAGGGAGACCCTCTGTGG
GTGAACGTGGGGCTGCTCCTTCTCAGCCTGCTGGGCTTCTGCCTCCCGCTCTACCTGATC
TGCTACCGGCGCCAGCTGGAGCGGCAGCTGCAGCAGAGGCAGGAGGATGACAAACTCTTC
CTCAAAATCAACGGCTCGTCCAACCAGGAGGCCTTCGTGTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AB120364

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_3_Locus:
17p13.3

# Macromolecular_Interacting_Partner_3_SNPs:
rs13342837; rs939564; rs1051820; rs7342891; rs2280457; rs1057123; rs1054541; rs4423477; rs8065481; rs4790713; rs9909877; rs6502794; rs7214236; rs4790653; rs8069863; rs4790232; rs4790712; rs8066678; rs4790715; rs11652773; rs2280461; rs9898376; rs3809800; rs8066066; rs5019940; rs8073151; rs9907798; rs6502826; rs9910358; rs1054539; rs11870087; rs4239049; rs9891989; rs11652817; rs2013905; rs7214201; rs11868468; rs17626180; rs7210368; rs9908061; rs11652194; rs5018812; rs17821354; rs12450869; rs7503031; rs11658414; rs2280456; rs876789; rs6502803; rs9905733; rs4790667; rs9893937; rs7219369; rs7209071; rs4239048; rs12603919; rs7222858; rs6502802; rs8068736; rs4790238; rs4790660; rs12450088; rs4790666; rs2003109; rs9899989; rs8076586; rs9903662; rs12451477; rs12943313; rs12450380; rs9911336; rs8064934; rs7223748; rs12946691; rs8081142; rs7222193; rs9709029; rs3760461; rs12940386; rs12939034; rs11651656; rs9709222; rs6502818; rs12946255; rs8075404; rs9709382; rs4790664; rs9904084; rs6502816; rs11871898; rs4790652; rs7503387; rs7214591; rs10445290; rs12941834; rs11871893; rs9896599; rs7216280; rs12939592; rs12950544; rs8076758; rs11656606; rs9894482; rs12603658; rs12453258; rs4790708; rs4790724; rs12942362; rs9902296; rs4790651; rs7503914; rs12940028; rs6502796; rs11656017; rs9911701; rs1054538; rs4790650; rs8072208; rs8065694; rs11871321; rs8075750; rs11654602; rs7211336; rs8070038; rs7406591; rs9906910; rs12946826; rs9893867; rs6502793; rs4790733; rs4790732; rs7214099; rs34412033; rs12936338; rs36013798; rs3180367; rs5818817; rs4995767; rs4790241; rs4790727; rs1051844; rs9893731; rs12453377; rs9895731; rs35952871; rs5018811; rs34062926; rs34123904; rs35986054; rs4790658; rs4790237; rs35701443; rs4790717; rs34454811; rs34897893; rs7224876; rs12944516; rs8065678; rs35473964; rs10534238; rs9893515; rs9893037; rs2002673; rs10669185; rs35529287; rs33950123; rs4790668; rs9892753; rs12951283; rs5818807; rs5019939; rs12946197; rs12946736; rs8078489; rs11870394; rs12952141; rs12948388; rs35004462; rs35758739; rs35637670; rs11377420; rs9709201; rs34034048; rs11869773; rs33959232; rs28588675; rs35737749; rs11868782; rs28798822; rs35711534; rs12949271; rs5818811; rs10667483; rs35832030; rs11321695; rs28376510; rs11868411; rs35181236; rs5818816; rs7213088; rs4790703; rs34288494; rs8078582; rs36105596; rs4790228; rs7211755; rs3809799; rs4353527; rs4602094; rs11657591; rs4994702; rs10542912; rs35826381; rs36066390; rs10691065; rs9709023; rs34146054; rs12946735; rs7210633; rs35740453; rs5818812; rs10581796; rs7406994; rs12952332; rs9890424; rs12948799; rs12952338; rs35178364; rs12946322; rs35159020; rs7213112; rs35007897; rs4790208; rs11327685; rs35942409; rs5818815; rs4790227; rs4290528; rs35969643; rs12939321; rs4790661; rs35479391; rs9893753; rs34155198; rs4790720; rs12937576; rs35780448; rs12938875; rs5818808; rs34417483; rs35833132; rs11463729; rs10556012; rs11870396; rs12951553; rs35775166; rs4452014; rs9709111; rs35314868; rs4790669; rs12939032; rs9911948; rs35844335; rs12601048; rs9903190; rs35703900; rs4790226; rs9897632; rs35348910; rs35157880; rs34481585; rs35312453; rs34645328; rs1107765; rs13340988; rs13341542; rs34297715; rs34849297; rs35455643; rs35874481; rs36108564; rs3744643; rs3744644; rs3760460; rs4790250; rs7210066; rs7220535; rs7222425; rs8072430; rs8078917; rs9889287; rs9902471; rs9910870; rs9912776

# Macromolecular_Interacting_Partner_3_General_References:
Not Available

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8656

# Macromolecular_Interacting_Partner_4_Name:
Cationic amino acid transporter 3

# Macromolecular_Interacting_Partner_4_Synonyms:
CAT-3; Solute carrier family 7 member 3; Cationic amino acid transporter y+

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC7A3

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Cationic amino acid transporter 3
MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD
KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS
YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA
LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL
GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF
AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI
YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL
VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC
SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK
VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR
KSRAKTVDLDPGTLYVHSV

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
619

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
67170

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.11

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
 Function:  amino acid permease activity
Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
 Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_4_Specific_Function:
Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_4_Signals:
1-305

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
37-57
62-82
108-128
163-183
192-212
234-254
286-306
336-356
383-403
407-427
476-496
507-527
541-561
570-590

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
17224957

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
CTR3_HUMAN (Q8WY07)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC7A3

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC7A3

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11061

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cell membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1860 bp
ATGCCGTGGCAAGCATTTCGCAGATTTGGTCAAAAGCTGGTACGCAGACGTACACTGGAG
TCAGGCATGGCTGAGACTCGCCTTGCCAGATGCCTAAGCACCCTGGATTTAGTGGCCCTG
GGTGTGGGCAGCACATTGGGTGCAGGCGTGTATGTCCTAGCTGGCGAGGTGGCCAAAGAT
AAAGCAGGGCCATCCATTGTGATCTGCTTTTTGGTGGCTGCCCTGTCTTCTGTGTTGGCT
GGGCTGTGCTATGCGGAGTTTGGTGCCCGGGTTCCCCGTTCTGGTTCGGCATATCTCTAC
AGCTATGTCACTGTGGGTGAACTCTGGGCCTTCACCACTGGCTGGAACCTCATCCTCTCC
TATGTCATTGGTACAGCCAGTGTGGCCCGGGCCTGGAGCTCTGCTTTTGACAACCTGATT
GGGAACCACATCTCTAAGACTCTGCAGGGGTCCATTGCACTGCACGTGCCCCATGTCCTT
GCAGAATATCCAGATTTCTTTGCTTTGGGCCTCGTGTTGCTGCTCACTGGATTGTTGGCT
CTCGGGGCTAGTGAGTCGGCCCTGGTTACCAAAGTGTTCACAGGCGTGAACCTTTTGGTT
CTTGGGTTCGTCATGATCTCTGGCTTCGTTAAGGGGGACGTGCACAACTGGAAGCTCACA
GAAGAGGACTACGAATTGGCCATGGCTGAACTCAATGACACCTATAGCTTGGGTCCTCTG
GGCTCTGGAGGATTTGTGCCTTTCGGCTTCGAGGGAATTCTCCGTGGAGCAGCGACCTGT
TTCTATGCATTTGTTGGTTTCGACTGTATTGCTACCACTGGAGAAGAAGCCCAGAATCCC
CAGCGTTCCATCCCGATGGGCATTGTGATCTCACTGTCTGTCTGCTTTTTGGCGTATTTT
GCTGTCTCTTCTGCACTCACCCTGATGATGCCTTACTACCAGCTTCAGCCTGAGAGCCCT
TTGCCTGAGGCATTTCTCTACATTGGATGGGCTCCTGCCCGCTATGTTGTGGCTGTTGGC
TCCCTCTGTGCTCTTTCTACCAGCCTCCTGGGCTCCATGTTCCCCATGCCTCGGGTGATC
TACGCGATGGCAGAGGATGGCCTCCTGTTCCGTGTACTTGCTCGGATCCACACCGGCACA
CGCACCCCAATCATAGCCACCGTGGTCTCTGGCATTATTGCAGCATTCATGGCATTCCTC
TTCAAACTCACTGATCTTGTGGACCTCATGTCAATTGGGACCCTGCTTGCTTACTCCCTG
GTGTCGATTTGTGTTCTCATCCTCAGGTATCAACCTGATCAGGAGACAAAGACTGGGGAA
GAAGTGGAGTTGCAGGAGGAGGCAATAACTACTGAATCAGAGAAGTTGACCCTATGGGGA
CTATTTTTCCCACTCAACTCCATCCCCACTCCACTCTCTGGCCAAATTGTCTATGTTTGT
TCCTCATTGCTTGCTGTCCTGCTGACTGCTCTTTGCCTGGTGCTGGCCCAGTGGTCAGTT
CCATTGCTTTCTGGAGACCTGCTGTGGACTGCAGTGGTTGTGCTGCTCCTGCTGCTCATT
ATTGGGATCATTGTGGTCATCTGGAGACAGCCACAGAGTTCCACTCCCCTTCACTTTAAG
GTGCCTGCTTTGCCTCTCCTCCCACTAATGAGCATCTTTGTGAATATTTACCTTATGATG
CAGATGACAGCTGGTACCTGGGCCCGATTTGGGGTCTGGATGCTGATTGGCTTTGCTATC
TACTTCGGCTATGGGATCCAGCACAGCCTGGAAGAGATTAAGAGTAACCAACCCTCACGC
AAGTCTAGAGCCAAAACTGTAGACCTTGATCCCGGCACTCTCTATGTCCACTCAGTTTGA


# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
AF320612

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_4_Locus:
Xq13.1

# Macromolecular_Interacting_Partner_4_SNPs:
rs6525447; rs5936604; rs7885836; rs6625713; rs7890581; rs7886610; rs7891155; rs4524964; rs17853219; rs4360450; rs5902678; rs41310635; rs34548199; rs12556893; rs4844277; rs4844278; rs4844279; rs4844280; rs5936607; rs5936609; rs5936610; rs5937024; rs5937025; rs5981030; rs6624517; rs6625721; rs7881738

# Macromolecular_Interacting_Partner_4_General_References:
11591158

# Macromolecular_Interacting_Partner_4_References:
Not Available

# Macromolecular_Interacting_Partner_5_ID:
8673

# Macromolecular_Interacting_Partner_5_Name:
Sodium-coupled neutral amino acid transporter 4

# Macromolecular_Interacting_Partner_5_Synonyms:
Na(+-coupled neutral amino acid transporter 4; Amino acid transporter A3; System A amino acid transporter 3; System N amino acid transporter 3; Solute carrier family 38 member 4

# Macromolecular_Interacting_Partner_5_Gene_Name:
SLC38A4

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Sodiumcoupled neutral amino acid transporter 4
MDPMELRNVNIEPDDESSSGESAPDSYIGIGNSEKAAMSSQFANEDTESQKFLTNGFLGK
KKLADYADEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSL
YSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEV
IRAFMGLEENTGEWYLNGNYLIIFVSVGIILPLSLLKNLGYLGYTSGFSLTCMVFFVSVV
IYKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLPNNSESSDVNFMMDYTHRNPAGLDEN
QAKGSLHDSGVEYEAHSDDKCEPKYFVFNSRTAYAIPILVFAFVCHPEVLPIYSELKDRS
RRKMQTVSNISITGMLVMYLLAALFGYLTFYGEVEDELLHAYSKVYTLDIPLLMVRLAVL
VAVTLTVPIVLFPIRTSVITLLFPKRPFSWIRHFLIAAVLIALNNVLVILVPTIKYIFGF
IGASSATMLIFILPAVFYLKLVKKETFRSPQKVGALIFLVVGIFFMIGSMALIIIDWIYD
PPNSKHH

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
547

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
60765

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.45

# Macromolecular_Interacting_Partner_5_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_5_Specific_Function:
Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_5_Signals:
1-531

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
81-101
105-125
152-172
196-216
221-241
333-353
370-390
412-432
454-474
477-497
515-535

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
13876616

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
S38A4_HUMAN (Q969I6)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
SLC38A4

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
SLC38A4

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:14679

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Cell membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1644 bp
ATGGATCCCATGGAACTGAGAAATGTCAACATCGAACCAGATGATGAGAGCAGCAGTGGA
GAAAGTGCTCCAGATAGCTACATCGGGATAGGAAATTCAGAAAAGGCAGCAATGAGCAGT
CAATTTGCTAATGAAGACACTGAAAGTCAGAAATTCCTGACAAATGGATTTTTGGGGAAA
AAGAAGCTGGCAGATTATGCTGATGAACACCATCCCGGAACCACTTCCTTTGGAATGTCT
TCATTTAACCTGAGTAATGCCATCATGGGCAGTGGGATCCTGGGCTTGTCCTATGCCATG
GCCAACACAGGGATCATACTTTTTATAATCATGCTGCTTGCTGTGGCAATATTATCACTG
TATTCAGTTCACCTTTTATTAAAAACAGCCAAGGAAGGAGGGTCTTTGATTTATGAAAAA
TTAGGAGAAAAGGCATTTGGATGGCCGGGAAAAATTGGAGCTTTTGTTTCCATTACAATG
CAGAACATTGGAGCAATGTCAAGCTACCTCTTTATCATTAAATATGAACTACCTGAAGTA
ATCAGAGCATTCATGGGACTTGAAGAAAATACTGGAGAATGGTACCTCAATGGCAACTAC
CTCATCATATTTGTGTCTGTTGGAATTATTCTTCCACTTTCGCTCCTTAAAAATTTAGGT
TATCTTGGCTATACCAGTGGATTTTCTCTTACCTGCATGGTGTTTTTTGTTAGTGTGGTG
ATTTACAAGAAATTCCAAATACCCTGCCCTCTACCTGTTTTGGATCACAGTGTTGGAAAT
CTGTCATTCAACAACACGCTTCCAATGCATGTGGTAATGTTACCCAACAACTCTGAGAGT
TCTGATGTGAACTTCATGATGGATTACACCCACCGCAATCCTGCAGGGCTGGATGAGAAC
CAGGCCAAGGGCTCTCTTCATGACAGTGGAGTAGAATATGAAGCTCATAGTGATGACAAG
TGTGAACCCAAATACTTTGTATTCAACTCCCGGACGGCCTATGCAATTCCTATCCTAGTA
TTTGCTTTTGTATGCCACCCTGAGGTCCTTCCCATCTACAGTGAACTTAAAGATCGGTCC
CGGAGAAAAATGCAAACGGTGTCAAATATTTCCATCACGGGGATGCTTGTCATGTACCTG
CTTGCCGCCCTCTTTGGTTACCTAACCTTCTATGGAGAAGTTGAAGATGAATTACTTCAT
GCCTACAGCAAAGTGTATACATTAGACATCCCTCTTCTCATGGTTCGCCTGGCAGTCCTT
GTGGCAGTAACACTAACTGTGCCCATTGTCCTCTTCCCAATTCGTACATCAGTGATCACA
CTGTTATTTCCCAAACGACCCTTCAGCTGGATACGACATTTCCTGATTGCAGCTGTGCTT
ATTGCACTTAATAATGTTCTGGTCATCCTTGTGCCAACTATAAAATACATCTTCGGATTC
ATAGGGGCTTCTTCTGCCACTATGCTGATTTTTATTCTTCCAGCAGTTTTTTATCTTAAA
CTTGTCAAGAAAGAAACTTTTAGGTCACCCCAAAAGGTCGGGGCTTTAATTTTCCTTGTG
GTTGGAATATTCTTCATGATTGGAAGCATGGCACTCATTATAATTGACTGGATTTATGAT
CCTCCAAATTCCAAGCATCACTAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AF305814

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_5_Locus:
12q13

# Macromolecular_Interacting_Partner_5_SNPs:
rs2429467; rs11183610; rs180414; rs2465604; rs2429472; rs2250010; rs2191162; rs2715788; rs2465608; rs2430921; rs4627160; rs11183605; rs180438; rs2897981; rs10881001; rs2079787; rs7974413; rs11183618; rs2429470; rs4482114; rs11183617; rs7963399; rs11183616; rs7967842; rs4587804; rs7132006; rs10161209; rs2109125; rs11183619; rs2465605; rs3862137; rs4569081; rs11183620; rs12321267; rs12582305; rs12424453; rs7968752; rs7954772; rs2429473; rs7963807; rs2465586; rs17097332; rs4447249; rs7138295; rs7959916; rs7953215; rs7973308; rs12304394; rs4491335; rs180437; rs12301396; rs10748455; rs2429471; rs12300935; rs4554975; rs12318696; rs10437941; rs7963364; rs10881002; rs7971412; rs7974393; rs12227634; rs17666239; rs12301345; rs11183621; rs17097341; rs10881003; rs180430; rs180431; rs2715779; rs2465585; rs180416; rs2465584; rs180421; rs1860372; rs180408; rs180433; rs180410; rs180409; rs180420; rs180417; rs7297226; rs4768758; rs2287471; rs180427; rs180419; rs2429474; rs4768759; rs2430922; rs2465583; rs6582676; rs180407; rs11183608; rs2465582; rs180434; rs180405; rs11183609; rs180426; rs180435; rs180412; rs2465644; rs12307687; rs180424; rs180429; rs180415; rs17097246; rs2075335; rs12305532; rs180428; rs12316767; rs2287472; rs12581848; rs12307218; rs4768757; rs180425; rs12317419; rs12306007; rs3794308; rs12301214; rs2302855; rs180423; rs180403; rs17097220; rs12313427; rs17602430; rs1860371; rs12826359; rs180422; rs2429465; rs2287473; rs17097286; rs11609184; rs2429466; rs180436; rs180404; rs1468970; rs1468972; rs1468971; rs2465614; rs4340151; rs2430920; rs2465613; rs12315893; rs7489259; rs7976413; rs7962993; rs7965688; rs7976286; rs4262792; rs12309262; rs35448881; rs5797999; rs12426237; rs34557682; rs10523982; rs12824626; rs2543339; rs4537845; rs34666594; rs2429469; rs10161451; rs34886536; rs5798000; rs4575359; rs11558891; rs9804926; rs10693721; rs4388977; rs2430923; rs2429468; rs34878223; rs3764027; rs2465606; rs2465588; rs35064296; rs17097355; rs34251832; rs12308177; rs1072246; rs2465587; rs4335624; rs5798001; rs2907513; rs12819255; rs4768756; rs2532606; rs11370884; rs34540549; rs12298652; rs34594658; rs4623983; rs35779004; rs35709312; rs2429464; rs10691485; rs12832145; rs35826321; rs180413; rs2216433; rs35066357; rs12319423; rs2465616; rs10691484; rs11610757; rs11315253; rs34637197; rs17097192; rs35050099; rs7313706; rs549755; rs36053062; rs11335369; rs3217194; rs11183614; rs12318924; rs4631970; rs34909119; rs12316757; rs180411; rs180432; rs10673975; rs34246069; rs35085914; rs180406; rs34654635; rs34189139; rs11335992; rs4439596; rs416435; rs35774013; rs5797998; rs3958775; rs35668113; rs446993; rs180418; rs34764764; rs34209899; rs11338774; rs10785645; rs11183625; rs11609070; rs11615573; rs12307895; rs12311057; rs12317975; rs12318756; rs12318994; rs12812119; rs17097368; rs17684703; rs2193649; rs2216432; rs2408623; rs2430917; rs2430919; rs2465595; rs2715775; rs2715783; rs4374015; rs4495962; rs4497488; rs4511364; rs4533116; rs4994910; rs7953233; rs7955552; rs7964210; rs7978689; rs7978822; rs7978926

# Macromolecular_Interacting_Partner_5_General_References:
11342143; 11414754

# Macromolecular_Interacting_Partner_5_References:
Not Available

# Macromolecular_Interacting_Partner_6_ID:
8787

# Macromolecular_Interacting_Partner_6_Name:
High-affinity cationic amino acid transporter 1

# Macromolecular_Interacting_Partner_6_Synonyms:
CAT-1; CAT1; System Y+ basic amino acid transporter; Ecotropic retroviral leukemia receptor homolog; ERR; Ecotropic retrovirus receptor homolog

# Macromolecular_Interacting_Partner_6_Gene_Name:
SLC7A1

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Highaffinity cationic amino acid transporter 1
MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE
NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS
YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT
LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG
KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA
YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR
VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY
SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI
LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA
VVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIY
FGYGLWHSEEASLDADQARTPDGNLDQCK

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
629

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
67639

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
5.06

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
 Function:  amino acid permease activity
Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
 Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_6_Specific_Function:
High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_6_Signals:
1-540

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
36-57
62-82
103-123
163-183
192-212
247-267
288-307
338-358
385-405
409-429
493-513
527-551
560-580
585-605

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
36161

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
CTR1_HUMAN (P30825)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SLC7A1

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SLC7A1

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:11057

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1890 bp
ATGGGGTGCAAAGTCCTGCTCAACATTGGGCAGCAGATGCTGCGGCGGAAGGTGGTGGAC
TGTAGCCGGGAGGAGACGCGGCTGTCTCGCTGCCTGAACACTTTTGATCTGGTGGCCCTC
GGGGTGGGCAGCACACTGGGTGCTGGTGTCTACGTCCTGGCTGGAGCTGTGGCCCGTGAG
AATGCAGGCCCTGCCATTGTCATCTCCTTCCTGATCGCTGCGCTGGCCTCAGTGCTGGCT
GGCCTGTGCTATGGCGAGTTTGGTGCTCGGGTCCCCAAGACGGGCTCAGCTTACCTCTAC
AGCTATGTCACCGTTGGAGAGCTCTGGGCCTTCATCACCGGCTGGAACTTAATCCTCTCC
TACATCATCGGTACTTCAAGCGTAGCGAGGGCCTGGAGCGCCACCTTCGACGAGCTGATA
GGCAGACCCATCGGGGAGTTCTCACGGACACACATGACTCTGAACGCCCCCGGCGTGCTG
GCTGAAAACCCCGACATATTCGCAGTGATCATAATTCTCATCTTGACAGGACTTTTAACT
CTTGGTGTGAAAGAGTCGGCCATGGTCAACAAAATATTCACTTGTATTAACGTCCTGGTC
CTGGGCTTCATAATGGTGTCAGGATTTGTGAAAGGATCGGTTAAAAACTGGCAGCTCACG
GAGGAGGATTTTGGGAACACATCAGGCCGTCTCTGTTTGAACAATGACACAAAAGAAGGG
AAGCCCGGTGTTGGTGGATTCATGCCCTTCGGGTTCTCTGGTGTCCTGTCGGGGGCAGCG
ACTTGCTTCTATGCCTTCGTGGGCTTTGACTGCATCGCCACCACAGGTGAAGAGGTGAAG
AACCCACAGAAGGCCATCCCCGTGGGGATCGTGGCGTCCCTCTTGATCTGCTTCATCGCC
TACTTTGGGGTGTCGGCTGCCCTCACGCTCATGATGCCCTACTTCTGCCTGGACAATAAC
AGCCCCCTGCCCGACGCCTTTAAGCACGTGGGCTGGGAAGGTGCCAAGTACGCAGTGGCC
GTGGGCTCCCTCTGCGCTCTTTCCGCCAGTCTTCTAGGTTCCATGTTTCCCATGCCTCGG
GTTATCTATGCCATGGCTGAGGATGGACTGCTATTTAAATTCTTAGCCAACGTCAATGAT
AGGACCAAAACACCAATAATCGCCACATTAGCCTCGGGTGCCGTTGCTGCTGTGATGGCC
TTCCTCTTTGACCTGAAGGACTTGGTGGACCTCATGTCCATTGGCACTCTCCTGGCTTAC
TCGTTGGTGGCTGCCTGTGTGTTGGTCTTACGGTACCAGCCAGAGCAGCCTAACCTGGTA
TACCAGATGGCCAGTACTTCCGACGAGTTAGATCCAGCAGACCAAAATGAATTGGCAAGC
ACCAATGATTCCCAGCTGGGGTTTTTACCAGAGGCAGAGATGTTCTCTTTGAAAACCATA
CTCTCACCCAAAAACATGGAGCCTTCCAAAATCTCTGGGCTAATTGTGAACATTTCAACC
AGCCTTATAGCTGTTCTCATCATCACCTTCTGCATTGTGACCGTGCTTGGAAGGGAGGCT
CTCACCAAAGGGGCGCTGTGGGCAGTCTTTCTGCTCGCAGGGTCTGCCCTCCTCTGTGCC
GTGGTCACGGGCGTCATCTGGAGGCAGCCCGAGAGCAAGACCAAGCTCTCATTTAAGGTT
CCCTTCCTGCCAGTGCTCCCCATCCTGAGCATCTTCGTGAACGTCTATCTCATGATGCAG
CTGGACCAGGGCACCTGGGTCCGGTTTGCTGTGTGGATGCTGATAGGCTTCATCATCTAC
TTTGGCTATGGCCTGTGGCACAGCGAGGAGGCGTCCCTGGATGCCGACCAAGCAAGGACT
CCTGACGGCAACTTGGACCAGTGCAAGTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
X59155

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:13

# Macromolecular_Interacting_Partner_6_Locus:
13q12-q14

# Macromolecular_Interacting_Partner_6_SNPs:
rs2482090; rs2482089; rs2277451; rs34747283; rs34981623; rs34374153; rs1571784; rs914362; rs1984029; rs3013641; rs532568; rs1571786; rs1546534; rs537151; rs280922; rs485359; rs9551699; rs476506; rs166828; rs280933; rs280930; rs9551700; rs7997827; rs2989596; rs2277452; rs280923; rs1984030; rs11839516; rs866573; rs280936; rs2490264; rs579451; rs1877463; rs819388; rs7338758; rs6490412; rs280934; rs280918; rs280950; rs7328329; rs3013640; rs6490411; rs280928; rs9579412; rs9579400; rs659314; rs928352; rs11617418; rs819386; rs11616506; rs3011605; rs280927; rs9579402; rs645783; rs528336; rs2776949; rs476931; rs478085; rs617892; rs7998704; rs12428751; rs1018679; rs10870625; rs555913; rs928353; rs7981502; rs9579401; rs10454589; rs11618529; rs928354; rs2482087; rs9579397; rs2989594; rs11842773; rs3011624; rs819385; rs9314962; rs9579406; rs10454590; rs17661173; rs9579405; rs1275359; rs1275360; rs3011623; rs1756442; rs280919; rs645778; rs12427581; rs3803266; rs280924; rs9578106; rs2776408; rs1756444; rs595454; rs9579411; rs4769759; rs11838366; rs9578108; rs17073704; rs11843711; rs9314960; rs12864238; rs11843217; rs280926; rs2776948; rs166827; rs2669039; rs9579398; rs9508499; rs581455; rs521924; rs13378570; rs1756440; rs2669038; rs583804; rs9285066; rs2277453; rs41318021; rs533768; rs280954; rs10220050; rs9578107; rs1756439; rs9314961; rs9579407; rs280931; rs9579408; rs521122; rs280925; rs280935; rs1571785; rs17602182; rs9551696; rs7328185; rs280917; rs2989595; rs1124594; rs9579410; rs3011604; rs1707099; rs11840806; rs532499; rs1756438; rs9506206; rs9550482; rs17073661; rs4769760; rs280946; rs3803268; rs17073703; rs1756441; rs280947; rs2802249; rs2802240; rs2490266; rs3011625; rs2802252; rs2183717; rs2776955; rs2776959; rs6490410; rs11838370; rs3783259; rs2989592; rs2776960; rs2482093; rs1411928; rs2490265; rs2274837; rs2150689; rs6490409; rs2776956; rs2490267; rs2989593; rs3825536; rs883055; rs2776957; rs3783248; rs3783263; rs2150693; rs9579393; rs3783257; rs9578105; rs3783252; rs2776953; rs12428026; rs9579389; rs9579392; rs2776963; rs2802250; rs2150688; rs2802251; rs2150690; rs9579391; rs17073593; rs1018680; rs2482091; rs7993193; rs9578103; rs9579383; rs3783262; rs3783260; rs2236499; rs2482094; rs2776961; rs17073592; rs3011626; rs9550477; rs9579395; rs2026322; rs11842525; rs2150692; rs7336765; rs9579386; rs2802248; rs17603017; rs2026321; rs1018682; rs2482092; rs17602454; rs9578104; rs7318388; rs7338132; rs2802247; rs3783261; rs12875683; rs3783256; rs9579384; rs2776958; rs2150687; rs2183716; rs17660515; rs9579388; rs2150691; rs9579390; rs9508484; rs9579387; rs2776981; rs2776978; rs2802243; rs2776979; rs2802244; rs1005720; rs2776980; rs2802245; rs7991247; rs9578112; rs1005719; rs9578111; rs34072234; rs36015789; rs9508482; rs36125077; rs34941634; rs11315574; rs35198653; rs9551703; rs9551701; rs34054173; rs577666; rs280915; rs9579399; rs10712529; rs2989597; rs34597896; rs3184811; rs1330940; rs553271; rs9579382; rs1330941; rs15376; rs657993; rs8002439; rs280937; rs28595095; rs11305795; rs36114772; rs7320543; rs1756437; rs34719566; rs10219858; rs34218459; rs9508481; rs34369885; rs819389; rs34568566; rs280916; rs9551702; rs34978805; rs2989343; rs34967062; rs34479939; rs1756443; rs35992531; rs12868663; rs11348485; rs9579381; rs819392; rs34676366; rs7318650; rs9551698; rs34831702; rs280912; rs34563180; rs9578110; rs1756436; rs9579415; rs280955; rs9579414; rs3837577; rs36029139; rs1973624; rs34299140; rs34361702; rs35639325; rs11460300; rs35434476; rs35321601; rs9579404; rs34351045; rs280913; rs643986; rs3840002; rs36035912; rs34000939; rs2776950; rs9508497; rs34757816; rs34015769; rs9551697; rs860203; rs554904; rs34185884; rs9550483; rs3069134; rs34323634; rs522946; rs280929; rs35499262; rs3011607; rs34578457; rs35375275; rs35332203; rs9508490; rs2137395; rs34460584; rs3011608; rs819391; rs36006415; rs175973; rs558623; rs12872613; rs35196293; rs280932; rs12429742; rs645278; rs478688; rs28635114; rs7991883; rs634006; rs35694290; rs11276846; rs9508493; rs35321845; rs11315575; rs28420801; rs34318271; rs554179; rs9579403; rs9314963; rs36010538; rs11342640; rs13378143; rs2669037; rs9579413; rs35344478; rs2776409; rs280914; rs11305796; rs7491758; rs819390; rs678844; rs35926133; rs553069; rs11321368; rs4769763; rs9579396; rs35303712; rs9550481; rs33910194; rs280956; rs3011606; rs12164856; rs9508501; rs527380; rs4280096; rs34087661; rs28661387; rs11839594; rs615487; rs35061715; rs12868785; rs34109300; rs10601093; rs3066083; rs9579394; rs34156069; rs9551694; rs17660403; rs2776952; rs35186629; rs4769757; rs34496705; rs34724516; rs28510575; rs883056; rs7321163; rs34839020; rs35134959; rs914361; rs35662476; rs2776954; rs9579385; rs35457554; rs10685808; rs34847757; rs4002219; rs9551693; rs34286791; rs34296494; rs1018681; rs35597255; rs34444950; rs3066085; rs35860131; rs7358958; rs9551695; rs3837579; rs9550478; rs5802525; rs36066583; rs4002218; rs9579416; rs879427; rs9578102; rs7991463; rs11618507; rs11842710; rs172179; rs2482096; rs2482097; rs2490268; rs2776982; rs2776983; rs2776984; rs2776985; rs2776986; rs2802246; rs3011619; rs3011620; rs34778716; rs4769015; rs529696; rs558107; rs598281; rs7333364; rs7333533; rs7333701; rs7986532; rs7990747; rs7996343; rs7996508; rs7999739; rs7999905; rs8000157; rs882953; rs9508495; rs9508502; rs9551705; rs9578113; rs9578114; rs9579380; rs9579417; rs9579421; rs9579422; rs9579424; rs9579425; rs9805210; rs9805211

# Macromolecular_Interacting_Partner_6_General_References:
1718082; 1348489; 10485994

# Macromolecular_Interacting_Partner_6_References:
Not Available

# Macromolecular_Interacting_Partner_7_ID:
8846

# Macromolecular_Interacting_Partner_7_Name:
OTTHUMP00000017019

# Macromolecular_Interacting_Partner_7_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Name:
SLC16A10

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>
OTTHUMP00000017019WVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLM
SSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILL
PLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRKKFS
PPKKIFNFAIFKVTAYAVWAVGIPLALFGYFVPYVHLAKFSFVILKYE

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
210

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
23037

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
9.91

# Macromolecular_Interacting_Partner_7_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_7_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF07690:MFS_1

# Macromolecular_Interacting_Partner_7_Signals:
1-21

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
5-24; 31-50; 55-77; 84-106; 116-136; 175-197

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
55664353

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
Q5VWW7_HUMAN (Q5VWW7)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
SLC16A10

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
SLC16A10

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:17027

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1548 bp
ATGGTGCTCTCCCAGGAGGAGCCGGACTCCGCGCGGGGCACGAGCGAGGCGCAGCCGCTC
GGCCCCGCGCCCACGGGGGCCGCTCCGCCGCCCGGCCCGGGACCCTCGGACAGCCCCGAG
GCGGCTGTCGAGAAGGTGGAGGTGGAGCTGGCGGGGCCGGCGACCGCGGAGCCCCATGAG
CCCCCCGAACCCCCCGAGGGCGGCTGGGGCTGGCTGGTGATGCTGGCGGCCATGTGGTGC
AACGGGTCGGTGTTCGGCATCCAGAACGCTTGCGGGGTGCTCTTCGTGTCCATGCTGGAA
ACCTTCGGCTCCAAAGACGATGACAAGATGGTCTTTAAGACAGCATGGGTAGGTTCTCTC
TCCATGGGGATGATTTTCTTTTGCTGCCCAATAGTCAGCGTCTTCACAGACCTATTTGGT
TGTCGGAAAACAGCTGTCGTGGGTGCTGCTGTTGGATTTGTTGGGCTCATGTCCAGTTCT
TTTGTAAGTTCCATCGAGCCTCTGTACCTTACCTATGGAATCATATTTGCCTGCGGCTGC
TCCTTTGCATACCAGCCTTCATTGGTCATTTTGGGACACTATTTCAAGAAGCGCCTTGGA
CTGGTGAATGGCATTGTCACTGCTGGCAGCAGTGTCTTCACAATCCTGCTGCCTTTGCTC
TTAAGGGTTCTGATTGACAGCGTGGGCCTCTTTTACACATTGAGGGTGCTCTGCATCTTC
ATGTTTGTTCTCTTTCTGGCTGGCTTTACTTACCGACCTCTTGCTACCAGTACCAAAGAT
AAAGAGAGTGGAGGTAGCGGATCCTCCCTCTTTTCCAGGAAAAAGTTCAGTCCTCCAAAA
AAAATTTTCAATTTTGCCATCTTCAAGGTGACAGCTTATGCAGTGTGGGCAGTTGGAATA
CCACTTGCACTTTTTGGATACTTTGTGCCTTATGTTCACTTGATGAAACATGTAAATGAA
AGATTTCAAGATGAAAAAAATAAAGAGGTTGTTCTCATGTGCATTGGCGTCACTTCAGGA
GTTGGACGACTGCTCTTTGGCCGGATTGCAGATTATGTGCCTGGTGTGAAGAAGGTTTAT
CTACAGGTACTCTCCTTTTTCTTCATTGGTCTGATGTCCATGATGATTCCTCTGTGTAGC
ATCTTTGGGGCCCTCATTGCTGTGTGCCTCATCATGGGTCTCTTCGATGGATGCTTCATT
TCCATTATGGCTCCCATAGCCTTTGAGTTAGTTGGTGCCCAGGATGTCTCCCAAGCAATT
GGATTTCTGCTCGGATTCATGTCTATACCCATGACTGTTGGCCCACCCATTGCAGGGTTA
CTTCGTGACAAACTGGGCTCCTATGATGTGGCATTCTACCTCGCTGGAGTCCCTCCCCTT
ATTGGAGGTGCTGTGCTTTGTTTTATCCCGTGGATCCATAGTAAGAAGCAAAGAGAGATC
AGTAAAACCACTGGAAAAGAAAAGATGGAGAAAATGTTGGAAAACCAGAACTCTCTGCTG
TCAAGTTCATCTGGAATGTTCAAGAAAGAATCTGACTCTATTATTTAA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
AL360227

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_7_Locus:
6q21-q22

# Macromolecular_Interacting_Partner_7_SNPs:
Not Available

# Macromolecular_Interacting_Partner_7_General_References:
Not Available

# Macromolecular_Interacting_Partner_7_References:
Not Available

# Macromolecular_Interacting_Partner_8_ID:
8881

# Macromolecular_Interacting_Partner_8_Name:
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

# Macromolecular_Interacting_Partner_8_Synonyms:
Amino acid transporter ATB0+; Solute carrier family 6 member 14

# Macromolecular_Interacting_Partner_8_Gene_Name:
SLC6A14

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Sodium and chloridedependent neutral and basic amino acid transporter B0+
MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVW
RFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGIT
MVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNK
GIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLA
LCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQ
SNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVF
AGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLG
LDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHF
CAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAI
FIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCC
RPASNWGPYLEQHRGERYKDMVDPKKEADHEIPTVSGSRKPE

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
642

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
72154

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
8.27

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
 Function:  transporter activity
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_8_Signals:
1-469

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
45-65
72-92
110-130
235-255
261-281
315-335
348-368
399-419
450-477
480-500
528-548
563-583

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
5732680

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
S6A14_HUMAN (Q9UN76)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
SLC6A14

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
SLC6A14

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:11047

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1929 bp
ATGGACAAGTTGAAATGCCCGAGTTTCTTCAAGTGCAGGGAGAAGGAGAAAGTGTCGGCT
TCATCAGAGAATTTCCATGTTGGTGAAAATGATGAGAATCAGGACCGTGGTAACTGGTCC
AAAAAATCGGATTATCTTCTATCTATGATTGGATACGCAGTGGGATTAGGAAATGTGTGG
AGATTTCCATATCTGACCTACAGCAATGGTGGAGGCGCCTTCTTGATACCTTATGCAATT
ATGTTAGCATTGGCTGGTTTACCTTTGTTCTTTCTGGAGTGTTCACTGGGACAATTTGCT
AGCTTAGGTCCAGTTTCAGTTTGGAGGATTCTTCCATTGTTTCAAGGTGTGGGAATTACA
ATGGTCCTGATCTCCATTTTTGTGACAATCTATTACAATGTCATAATTGCCTATAGTCTT
TACTACATGTTTGCTTCTTTTCAAAGTGAACTACCATGGAAAAATTGTTCTTCGTGGTCA
GATAAAAACTGTAGCAGATCACCAATAGTAACTCACTGTAATGTGAGTACAGTGAATAAA
GGAATACAAGAGATCATCCAAATGAATAAAAGCTGGGTAGACATCAACAATTTTACCTGC
ATCAACGGCAGTGAAATTTATCAGCCAGGGCAGCTTCCCAGTGAACAATATTGGAATAAA
GTGGCGCTCCAACGGTCAAGTGGAATGAATGAGACTGGAGTAATTGTTTGGTATTTAGCA
CTTTGTCTTCTTCTGGCTTGGCTCATAGTTGGAGCAGCACTATTTAAAGGAATCAAATCG
TCTGGCAAGGTGGTATATTTTACAGCTCTTTTCCCCTATGTGGTCCTACTCATCCTGTTA
GTACGAGGTGCAACTCTGGAGGGTGCTTCAAAAGGCATTTCATACTATATTGGAGCCCAG
TCAAATTTTACAAAACTTAAGGAAGCTGAGGTATGGAAAGATGCTGCCACTCAGATATTT
TACTCCCTTTCAGTGGCTTGGGGTGGCTTAGTTGCTCTATCATCTTACAATAAGTTCAAA
AACAACTGCTTCTCTGATGCCATTGTGGTTTGTTTGACAAACTGTCTCACTAGCGTGTTT
GCTGGATTTGCTATTTTTTCTATATTGGGACACATGGCCCATATATCTGGAAAGGAAGTT
TCTCAAGTTGTAAAATCAGGTTTTGATTTGGCATTCATTGCCTATCCAGAGGCTCTAGCC
CAACTCCCAGGTGGTCCATTTTGGTCCATATTATTTTTTTTCATGCTTTTAACTTTGGGT
CTCGATTCTCAGTTTGCTTCGATTGAAACGATCACAACAACAATTCAAGATTTATTTCCC
AAAGTGATGAAGAAAATGAGGGTTCCCATAACTTTGGGCTGCTGCTTGGTTTTGTTTCTC
CTTGGTCTCGTCTGTGTGACTCAGGCTGGAATTTACTGGGTTCATCTGATTGACCACTTC
TGTGCTGGATGGGGCATTTTAATTGCAGCTATACTGGAGCTAGTTGGAATCATCTGGATT
TATGGAGGGAACAGATTCATTGAGGATACAGAAATGATGATTGGAGCAAAGAGGTGGATA
TTCTGGCTATGGTGGAGAGCTTGCTGGTTTGTAATTACGCCTATCCTTTTGATTGCAATA
TTTATCTGGTCATTGGTGCAATTTCATAGACCTAATTATGGCGCAATTCCATACCCTGAC
TGGGGAGTTGCTTTAGGCTGGTGTATGATTGTTTTCTGCATTATTTGGATACCAATTATG
GCTATCATAAAAATAATTCAGGCTAAAGGAAACATCTTTCAACGCCTTATAAGTTGCTGC
AGACCAGCTTCTAACTGGGGTCCATACCTGGAACAACATCGTGGGGAAAGATATAAAGAC
ATGGTAGATCCTAAAAAAGAGGCTGACCATGAAATACCTACTGTTAGTGGCAGCAGAAAA
CCGGAATGA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
AF151978

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_8_Locus:
Xq23-q24

# Macromolecular_Interacting_Partner_8_SNPs:
rs12720074; rs2011162; rs5905179; rs12710570; rs5905289; rs2011198; rs2312055; rs2032525; rs5905176; rs5905284; rs7059155; rs2071877; rs4824325; rs10217924; rs5905178; rs6608646; rs12392462; rs2312057; rs12391221; rs17242824; rs5905288; rs12559530; rs10218102; rs10521579; rs12710569; rs10521578; rs5905285; rs5952101; rs12720080; rs12720088; rs5952099; rs12720083; rs5905177; rs4824358; rs4824324; rs12720076; rs4824359; rs12720084; rs12720079; rs5952103; rs2312056; rs12720089; rs17095419; rs12393509; rs4824323; rs2312054; rs7052454; rs12710568; rs12720073; rs12834312; rs3788766; rs5905283; rs12720085; rs28523889; rs6608648; rs11350870; rs34685017; rs28699570; rs12720092; rs28628632; rs12720078; rs5952174; rs35604008; rs5952104; rs5905287; rs6608645; rs12388847; rs10629819; rs12720087; rs12720091; rs35269408; rs17308739; rs3043424; rs35542990; rs5952100; rs5952102; rs35201069; rs6651554; rs12720077; rs10218234; rs6608647; rs12858125; rs34117081; rs5952175; rs12720082; rs34490652; rs4068397; rs7066547; rs7054956; rs12832551; rs10218418; rs12720075; rs12720086; rs12720090; rs35315031; rs7062559; rs10218017; rs12390279; rs12833869; rs12835480; rs12839137; rs12844003; rs17308697; rs2103697; rs2301451; rs5952181; rs6520234; rs6608511; rs6608514; rs6608644; rs6608650

# Macromolecular_Interacting_Partner_8_General_References:
10446133

# Macromolecular_Interacting_Partner_8_References:
Not Available

End of HMDB00159

Beginning of HMDB00161
# Accession_No:
HMDB00161

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-18 21:26:14

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
L-Alanine

# Description:
Alanine is a nonessential amino acid made in the body from the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and anserine. It is highly concentrated in muscle and is one of the most important amino acids released by muscle, functioning as a major energy source. Plasma alanine is often decreased when the BCAA (Branched Chain Amino Acids) are deficient. This finding may relate to muscle metabolism. Alanine is highly concentrated in meat products and other high-protein foods like wheat germ and cottage cheese. Alanine is an important participant as well as regulator in glucose metabolism. Alanine levels parallel blood sugar levels in both diabetes and hypoglycemia, and alanine reduces both severe hypoglycemia and the ketosis of diabetes. It is an important amino acid for lymphocyte reproduction and immunity. Alanine therapy has helped dissolve kidney stones in experimental animals. Normal alanine metabolism, like that of other amino acids, is highly dependent upon enzymes that contain vitamin B6. Alanine, like GABA, taurine and glycine, is an inhibitory neurotransmitter in the brain. http://www.dcnutrition.com/AminoAcids/)

# Synonyms:
(2S)-2-Aminopropanoate; (2S)-2-Aminopropanoic acid; (S)-(+)-Alanine; (S)-2-Aminopropanoate; (S)-2-Aminopropanoic acid; (S)-2-amino-Propanoate; (S)-2-amino-Propanoic acid; (S)-Alanine; 2-Aminopropanoate; 2-Aminopropanoic acid; 2-Aminopropionate; 2-Aminopropionic acid; 2-Ammoniopropanoate; Ala; Alanine; L-(+)-Alanine; L-2-Aminopropanoate; L-2-Aminopropanoic acid; L-2-Aminopropionate; L-2-Aminopropionic acid; L-a-Alanine; L-a-Aminopropionate; L-a-Aminopropionic acid; a-Alanine; a-Aminopropionate; a-Aminopropionic acid; alpha-Aminopropanoate; alpha-Aminopropanoic acid; L-alpha-Alanine; L-alpha-Aminopropionate; L-alpha-Aminopropionic acid; alpha-Alanine; alpha-Aminopropionate; alpha-Aminopropionic acid

# Chemical_IUPAC_Name:
2-aminopropanoic acid

# Chemical_Formula:
C3H7NO2

# Chemical_Structure:
tbl_chemical:::HMDB00161_ZOOM.png:::119283226283394351

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00161_THUMB.png:::119283226121795117

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids; Nitrogenous Compounds

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid; alpha-aminoacid

# Taxonomy_Biofunction:
Component of Alanine and aspartate metabolism; Component of Aminoacyl-tRNA biosynthesis; Component of Glutamate metabolism; Component of Glycine, serine and threonine metabolism; Component of Tryptophan metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
89.04768

# Molecular_Weight_Avg:
89.09318

# Smiles_String_isomeric:
C[C@H](N)C(O)=O

# Smiles_String_canonical:
CC(N)C(O)=O

# KEGG_Compound_ID:
C00041

# BioCyc_ID:
L-ALPHA-ALANINE

# PubChem_CID:
5950

# PubChem_SID:
700553; 3812682; 3343; 732376; 8153694; 7888688; 11532214; 11532615; 7988265; 822335; 7885836; 8144737; 824447; 583759; 8020302; 10527484; 627087; 7847080; 841591; 148776; 6436532; 11113404; 711020; 585842; 589753; 3131856

# OMIM_ID:
237400; 259900

# Metagene_ID:
Not Available

# BiGG_ID:
33629

# Wikipedia_ID:
2-Aminopropanoic acid

# METLIN_ID:
Not Available

# Ref_ID:
1631030; 15911239; 12297216; 14992292; 9625050; 16038; 7729054; 12097436; 11237944; 41707; 6696735; 6198473

# ChEBI_ID:
16977

# CAS_Registry_Number:
56-41-7

# InChI:
InChI=1/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1

# Synthesis_Reference:
Applied Microbiology  (1965),  13(5),  638-45.

# Melting_Point:
300 oC

# Melting_Point_predicted:
26.6 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
164.0 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]; 204 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
447.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-2.85 [SANGSTER (1994)]

# LogP_predicted:
-3.04 [Predicted by ALOGPS]; -2.8 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::L-Alanine.pdf:::1132562208781707281

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::L-Alanine.mol:::1132723811125427553

# SDF_File_[Text]:
tbl_chemical:::HMDB00161.sdf:::119283225827640205

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00161.pdb:::119283225984647074

# PDB_ID:
1KL6

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041021_P00_03_HW_1DP_PRESAT_expanded_2.gif:::114460742048710045

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041021_P00_03_HW_1DP_presat.zip:::1177710606452333977

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041021_P00_03_HW_1DP_Assigned.png:::114660956918570998

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::041021_P00_03_HW_1DC_36.jpg:::114168459907449036

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041021_P00_03_HW_1DC_36.zip:::114168459904375194

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041021_P00_03_HW_1DC_36_Assigned.jpg:::114332851836185567

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041021_P00_03_HW_2DHSQC_24.jpg:::114495021667082348

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041021_P00_03_HW_2DHSQC_24.zip:::114495021669086296

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041021_P00_03_HW_2DHSQC_24_Assigned.jpg:::114495021689163921

# Predicted_H_NMR_Spectrum:
tbl_chemical:::L-Alanine.gif:::113273211585920205

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00161_peaks.txt:::1156309586514392913

# Predicted_C_NMR_Spectrum:
tbl_chemical:::L-Alanine_C.gif:::1132737705316483451

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00161_peaks.txt:::1156310776203565330

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00161L.png:::117555261879539121; Medium Energy:tbl_ms:::HMDB00161M.png:::117555267009445952; High Energy:tbl_ms:::HMDB00161H.png:::1175552708755199

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000028.png:::116890823196885313

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000028.txt:::116890823196887316

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000028.png:::116890823164084336

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000028.txt:::116890823196850319

# Cellular_Location:
Cytoplasm; Extracellular; lysosome; mitochondria; peroxisome

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Urine	13.2	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9625050
Blood	333.0 (259.0-407.0)	umol/L	Adult:>18_yrs_old	Both	Normal	12297216
Blood	375.0 +/- 50.0	umol/L	Newborn:0-30_days_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	369.0 +/- 88.0	umol/L	Children:1-13_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	272.0 +/- 36.0	umol/L	Children:1-13_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 93. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	404.0 +/- 94.0	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 93. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	377.0 +/- 108.0	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 93. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	37.8 +/- 6.8	umol/L	Adult:>18_yrs_old	N/A	Normal	15911239
Cerebrospinal_Fluid(CSF)	30.8 +/- 8.7	umol/L	Adult:>18_yrs_old	N/A	Normal	6198473
Cerebrospinal_Fluid(CSF)	26.3 +/- 7.4	umol/L	Adult:>18_yrs_old	N/A	Normal	6198473
Cerebrospinal_Fluid(CSF)	174.0 +/- 108.0	uM	Adult:>18_yrs_old	Both	Normal	HMP Experimental
Cerebrospinal_Fluid(CSF)	27.0 (10.0-44.0)	umol/L	Adult:>18_yrs_old	Both	Normal	7729054
Cerebrospinal_Fluid(CSF)	23.2 +/- 5.1	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Saliva	>10	umol/L	Adult:>18_yrs_old	Both	Normal	12097436


# Concentration_[Abnormal]:
Urine	23 (10-55)	umol/mmol_creatinine	N/A	Both	Lung Cancer	
Urine	76.3	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Paraquat poisoning	9625050
Blood	190.0	umol/L	Adult:>18_yrs_old	Both	Diabetes	6696735
Blood	274.0 (250.0-298.0)	umol/L	Adult:>18_yrs_old	Both	Dengue	11237944
Blood	296.0 (277.0-316.0)	umol/L	Adult:>18_yrs_old	Both	Acute seizures	14992292
Cerebrospinal_Fluid(CSF)	46.1 +/- 13.5	umol/L	N/A	N/A	Leukemia with CNS disease	15911239
Cerebrospinal_Fluid(CSF)	34.8 +/- 7.8	umol/L	N/A	N/A	Leukemia	15911239
Cerebrospinal_Fluid(CSF)	0.16 (0.13-0.18)	umol/L	Adult:>18_yrs_old	Both	Bacterial meningitis	7729054
Cerebrospinal_Fluid(CSF)	19.2 (16.1-22.3)	umol/L	Adult:>18_yrs_old	Both	Tuberculosis	7729054


# Associated_Disorders:
Acute Hepatitis B; Acute seizures; Bacterial meningitis; Circulatory Failure; Dengue; Diabetes; Disc herniation; Kidney Damage; Lactic Acidemia; Leukemia; Leukemia with CNS disease; Lung Cancer; Paraquat poisoning; Refractory localization-related epilepsy (RLE); Spina bifida; Tuberculosis

# Pathway_Names:
Alanine and aspartate metabolism

# Pathway_Images:
Aspartate_and_Alanine_metabolism.jpg

# KEGG_Images:
map00252

# Pathway_Graphs:
Aspartate_and_Alanine_metabolism_Graph.jpg

# Pathway_SBMLs:
Aspartate_and_Alanine_metabolism.xml

# Metabolic_Enzyme_1_ID:
6069

# Metabolic_Enzyme_1_Name:
Serine--pyruvate aminotransferase

# Metabolic_Enzyme_1_Synonyms:
SPT; Alanine-- glyoxylate aminotransferase; AGT

# Metabolic_Enzyme_1_Gene_Name:
AGXT

# Metabolic_Enzyme_1_Protein_Sequence:
>Serinepyruvate aminotransferase
MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEI
KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG
ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLL
LVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF
YLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHG
RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLR
IGLLGCNATRENVDRVTEALRAALQHCPKKKL

# Metabolic_Enzyme_1_Number_of_Residues:
392

# Metabolic_Enzyme_1_Molecular_Weight:
43011

# Metabolic_Enzyme_1_Theoretical_pI:
8.55

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
L-serine + pyruvate = 3-hydroxypyruvate + L- alanine

# Metabolic_Enzyme_1_Pathway:
map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_1_Reaction:
L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00266:Aminotran_5

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.6.1.51;EC 2.6.1.44

# Metabolic_Enzyme_1_GenBank_ID_Protein:
36582

# Metabolic_Enzyme_1_SwissProt_ID:
SPYA_HUMAN (P21549)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
AGXT

# Metabolic_Enzyme_1_Geneatlas_id:
AGXT

# Metabolic_Enzyme_1_hgnc_id:
HGNC:341

# Metabolic_Enzyme_1_PDB_ID:
1H0C

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Peroxisome. Note=Except in some PH1 patients where AGT is found in the mitochondrial matrix

# Metabolic_Enzyme_1_Gene_Sequence:
>1179 bp
ATGGCCTCTCACAAGCTGCTGGTGACCCCCCCCAAGGCCCTGCTCAAGCCCCTCTCCATC
CCCAACCAGCTCCTGCTGGGGCCTGGTCCTTCCAACCTGCCTCCTCGCATCATGGCAGCC
GGGGGGCTGCAGATGATCGGGTCCATGAGCAAGGATATGTACCAGATCATGGACGAGATC
AAGGAAGGCATCCAGTACGTGTTCCAGACCAGGAACCCACTCACACTGGTCATCTCTGGC
TCGGGACACTGTGCCCTGGAGGCCGCCCTGGTCAATGTGCTGGAGCCTGGGGACTCCTTC
CTGGTTGGGGCCAATGGCATTTGGGGGCAGCGAGCCGTGGACATCGGGGAGCGCATAGGA
GCCCGAGTGCACCCGATGACCAAGGACCCTGGAGGCCACTACACACTGCAGGAGGTGGAG
GAGGGCCTGGCCCAGCACAAGCCAGTGCTGCTGTTCTTAACCCACGGGGAGTCGTCCACC
GGCGTGCTGCAGCCCCTTGATGGCTTCGGGGAACTCTGCCACAGGTACAAGTGCCTGCTC
CTGGTGGATTCGGTGGCATCCCTGGGCGGGACCCCCCTTTACATGGACCGGCAAGGCATC
GACATCCTGTACTCGGGCTCCCAGAAGGCCCTGAACGCCCCTCCAGGGACCTCGCTCATC
TCCTTCAGTGACAAGGCCAAAAAGAAGATGTACTCCCGCAAGACGAAGCCCTTCTCCTTC
TACCTGGACATCAAGTGGCTGGCCAACTTCTGGGGCTGTGACGACCAGCCCAGGATGTAC
CATCACACAATCCCCGTCATCAGCCTGTACAGCCTGAGAGAGAGCCTGGCCCTCATTGCG
GAACAGGGCCTGGAGAACAGCTGGCGCCAGCACCGCGAGGCCGCGGCGTATCTGCATGGG
CGCCTGCAGGCACTGGGGCTGCAGCTCTTCGTGAAGGACCCGGCGCTCCGGCTTCCCACA
GTCACCACTGTGGCTGTACCCGCTGGCTATGACTGGAGAGACATCGTCAGCTACGTCATA
GACCACTTCGACATTGAGATCATGGGTGGCCTTGGGCCCTCCACGGGGAAGGTGCTGCGG
ATCGGCCTGCTGGGCTGCAATGCCACCCGCGAGAATGTGGACCGCGTGACGGAGGCCCTG
AGGGCGGCCCTGCAGCACTGCCCCAAGAAGAAGCTGTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X56092

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_1_Locus:
2q36-q37

# Metabolic_Enzyme_1_SNPs:
rs4426527; rs13408961; rs34885252; rs34116584; rs33958047; rs4273214; rs4344931; rs4073369; rs4073370; rs12695032; rs6732985; rs4073597; rs10199038; rs11681134; rs11894759; rs12478859; rs10933640; rs4355101; rs13430507; rs13423821; rs5021686; rs5013752; rs11901056; rs11687303; rs10933641; rs13030904; rs11693280; rs11685698; rs11886288; rs4675876; rs4675875; rs4234095; rs10182575; rs34664134; rs35977912; rs35698882; rs3196760; rs4991357; rs11682457; rs11688815; rs11691745; rs35882315; rs12997245; rs4991356; rs33996129; rs6722479; rs4991354; rs4414673; rs5839789; rs35937797; rs12464426; rs4991360; rs34134404; rs35561942; rs4991355; rs5839787; rs34995778; rs34572785; rs10196315; rs13020254; rs11691886; rs35566646; rs5839788; rs4257395; rs4991359; rs5013751; rs4328626; rs4991361; rs35172778; rs5839786; rs4991358; rs5021687; rs4675793; rs12622523; rs34927888; rs12998301; rs11897804; rs7568864; rs4675877; rs6718131; rs35931917; rs35082207; rs12619921; rs6717643; rs10177846; rs10178744; rs10185214; rs10933510; rs1138103; rs11680732; rs11681382; rs11686679; rs11689640; rs11886874; rs11899555; rs12616061; rs12991730; rs12994627; rs13000529; rs13001584; rs13007644; rs13025495; rs13030611; rs13385816; rs13387029; rs13397515; rs13410652; rs33998315; rs34927891; rs36014033; rs4129624; rs4295000; rs4311055; rs4312490; rs4465762; rs4538195; rs4675792; rs4675869; rs4675871; rs4675872; rs4675874; rs6437372; rs6707763; rs6708304; rs6741220; rs6744422; rs7340215; rs7340501; rs7355583; rs7557279; rs7590032; rs7598309; rs7600847; rs7601670; rs7604393; rs7606856; rs9288742

# Metabolic_Enzyme_1_General_References:
2253628; 1703535; 2363689; 2045108; 2039493; 1349575; 1301173; 8101040; 8507692; 9192270; 10394939; 10862087

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5633

# Metabolic_Enzyme_2_Name:
Alanine--glyoxylate aminotransferase 2, mitochondrial precursor

# Metabolic_Enzyme_2_Synonyms:
(R-3-amino-2-methylpropionate--pyruvate transaminase; AGT 2; Beta-alanine-pyruvate aminotransferase; Beta- ALAAT II; D-AIBAT

# Metabolic_Enzyme_2_Gene_Name:
AGXT2

# Metabolic_Enzyme_2_Protein_Sequence:
>Alanineglyoxylate aminotransferase 2, mitochondrial precursor
MTLIWRHLLRPLCLVTSAPRILEMHPFLSLGTSRTSVTKLSLHTKPRMPPCDFMPERYQS
LGYNRVLEIHKEHLSPVVTAYFQKPLLLHQGHMEWLFDAEGSRYLDFFSGIVTVSVGHCH
PKVNAVAQKQLGRLWHTSTVFFHPPMHEYAEKLAALLPEPLKVIFLVNSGSEANELAMLM
ARAHSNNIDIISFRGAYHGCSPYTLGLTNVGTYKMELPGGTGCQPTMCPDVFRGPWGGSH
CRDSPVQTIRKCSCAPDCCQAKDQYIEQFKDTLSTSVAKSIAGFFAEPIQGVNGVVQYPK
GFLKEAFELVRARGGVCIADEVQTGFGRLGSHFWGFQTHDVLPDIVTMAKGIGNGFPMAA
VITTPEIAKSLAKCLQHFNTFGGNPMACAIGSAVLEVIKEENLQENSQEVGTYMLLKFAK
LRDEFEIVGDVRGKGLMIGIEMVQDKISCRPLPREEVNQIHEDCKHMGLLVGRGSIFSQT
FRIAPSMCITKPEVDFAVEVFRSALTQHMERRAK

# Metabolic_Enzyme_2_Number_of_Residues:
514

# Metabolic_Enzyme_2_Molecular_Weight:
57157

# Metabolic_Enzyme_2_Theoretical_pI:
7.91

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
L-alanine + glyoxylate = pyruvate + glycine

# Metabolic_Enzyme_2_Pathway:
map00252  Alanine and aspartate metabolism;
 map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_2_Reaction:
L-alanine + glyoxylate = pyruvate + glycine

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00202:Aminotran_3

# Metabolic_Enzyme_2_Signals:
1-24

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.6.1.44;EC 2.6.1.40

# Metabolic_Enzyme_2_GenBank_ID_Protein:
12406973

# Metabolic_Enzyme_2_SwissProt_ID:
AGT2_HUMAN (Q9BYV1)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
AGXT2

# Metabolic_Enzyme_2_Geneatlas_id:
AGXT2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:14412

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Mitochondrion (Potential)

# Metabolic_Enzyme_2_Gene_Sequence:
>1545 bp
ATGACTCTAATCTGGAGACATTTGCTGAGACCCTTGTGCCTGGTCACTTCCGCTCCCAGG
ATCCTTGAGATGCATCCTTTCCTGAGCCTAGGTACTTCCCGGACATCAGTAACCAAGCTC
AGTCTTCATACAAAGCCCAGAATGCCTCCATGTGACTTCATGCCTGAAAGATACCAGTCC
CTTGGCTACAACCGTGTCCTGGAAATCCACAAGGAACATCTTTCTCCTGTGGTGACGGCA
TATTTCCAGAAACCCCTGCTGCTCCACCAGGGGCACATGGAGTGGCTCTTTGATGCTGAA
GGAAGCAGATACCTGGATTTCTTTTCCGGGATTGTTACTGTCAGTGTTGGCCATTGCCAC
CCAAAGGTGAATGCAGTGGCACAAAAGCAGCTCGGCCGCCTGTGGCATACAAGCACCGTC
TTCTTCCACCCTCCAATGCATGAATATGCAGAGAAGCTTGCCGCACTTCTTCCTGAGCCT
CTTAAGGTCATTTTCTTGGTGAACAGTGGCTCAGAAGCCAATGAGCTGGCCATGCTGATG
GCCAGGGCGCACTCAAACAACATAGACATCATTTCTTTCAGAGGAGCCTACCATGGATGC
AGTCCTTACACACTTGGCTTGACAAACGTAGGGACCTACAAGATGGAACTCCCTGGTGGG
ACAGGTTGCCAACCAACAATGTGTCCAGATGTTTTTCGTGGCCCTTGGGGAGGAAGCCAC
TGTCGAGATTCTCCAGTGCAAACAATCAGGAAGTGCAGCTGTGCACCAGACTGCTGCCAA
GCTAAAGATCAGTATATTGAGCAATTCAAAGATACGCTGAGCACATCTGTGGCCAAGTCA
ATTGCTGGATTTTTCGCAGAACCTATTCAAGGTGTGAATGGAGTTGTCCAGTACCCAAAG
GGGTTTCTAAAGGAAGCCTTTGAGCTGGTGCGAGCAAGGGGAGGCGTGTGCATTGCAGAT
GAAGTGCAGACAGGATTTGGAAGGTTGGGCTCTCACTTCTGGGGCTTCCAAACCCACGAT
GTCCTGCCTGACATTGTCACCATGGCTAAAGGGATTGGGAATGGCTTTCCCATGGCAGCA
GTCATAACCACTCCAGAGATTGCCAAATCTTTGGCGAAATGCCTGCAGCACTTCAACACC
TTTGGAGGGAACCCCATGGCCTGTGCCATTGGATCTGCTGTGCTTGAGGTGATTAAAGAA
GAAAATCTACAGGAAAACAGTCAAGAAGTTGGGACCTACATGTTACTAAAGTTTGCTAAG
CTGCGGGATGAATTTGAAATTGTTGGAGACGTCCGAGGCAAAGGTCTCATGATAGGCATA
GAAATGGTGCAGGATAAGATAAGCTGTCGGCCTCTTCCCCGTGAAGAAGTAAATCAGATC
CATGAGGACTGCAAGCACATGGGACTCCTCGTTGGCAGAGGCAGCATTTTTTCTCAGACA
TTTCGCATTGCGCCCTCAATGTGCATCACTAAACCAGAAGTTGATTTTGCAGTAGAAGTA
TTTCGTTCTGCCTTAACCCAACACATGGAAAGAAGAGCTAAGTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AJ292204

# Metabolic_Enzyme_2_Chromosome_Location:
Not Available

# Metabolic_Enzyme_2_Locus:
Not Available

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
Not Available

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5897

# Metabolic_Enzyme_3_Name:
Alanyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_3_Synonyms:
Alanine--tRNA ligase; AlaRS; Renal carcinoma antigen NY-REN-42

# Metabolic_Enzyme_3_Gene_Name:
AARS

# Metabolic_Enzyme_3_Protein_Sequence:
>AlanyltRNA synthetase, cytoplasmic
MDSTLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPS
HPMAKLSRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALE
LLTQEFGIPIERLYVTYFGGDEAAGLEADLECKQIWQNLGLDDTKILPGNMKDNFWEMGD
TGPCGPCSEIHYDRIGGRDAAHLVNQDDPNVLEIWNLVFIQYNREADGILKPLPKKSIDT
GMGLERLVSVLQNKMSNYDTDLFVPYFEAIQKGTGARPYTGKVGAEDADGIDMAYRVLAD
HARTITVALADGGRPDNTGRGYVLRRILRRAVRYAHEKLNASRGFFATLVDVVVQSLGDA
FPELKKDPDMVKDIINEEEVQFLKTLSRGRRILDRKIQSLGDSKTIPGDTAWLLYDTYGF
PVDLTGLIAEEKGLVVDMDGFEEERKLAQLKSQGKGAGGEDLIMLDIYAIEELRARGLEV
TDDSPKYNYHLDSSGSYVFENTVATVMALRREKMFVEEVSTGQECGVVLDKTCFYAEQGG
QIYDEGYLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYGDLKVGDQVWLFIDEPRRRP
IMSNHTATHILNFALRSVLGEADQKGSLVAPDRLRFDFTAKGAMSTQQIKKAEEIANEMI
EAAKAVYTQDCPLAAAKAIQGLRAVFDETYPDPVRVVSIGVPVSELLDDPSGPAGSLTSV
EFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKAESLKKCLSVMEAK
VKAQTAPNKDVQREIADLGEALATAVIPQWQKDELRETLKSLKKVMDDLDRASKADVQKR
VLEKTKQFIDSNPNQPLVILEMESGASAKALNEALKLFKMHSPQTSAMLFTVDNEAGKIT
CLCQVPQNAANRGLKASEWVQQVSGLMDGKGGGKDVSAQATGKNVGCLQEALQLATSFAQ
LRLGDVKN

# Metabolic_Enzyme_3_Number_of_Residues:
968

# Metabolic_Enzyme_3_Molecular_Weight:
106812

# Metabolic_Enzyme_3_Theoretical_pI:
5.18

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  alanine-tRNA ligase activity
Function:  binding
Function:  nucleic acid binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  alanyl-tRNA aminoacylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_3_Specific_Function:
ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)

# Metabolic_Enzyme_3_Pathway:
map00252  Alanine and aspartate metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_3_Reaction:
ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF02272:DHHA1;
PF01411:tRNA-synt_2c;
PF07973:tRNA_SAD

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 6.1.1.7

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1015321

# Metabolic_Enzyme_3_SwissProt_ID:
SYAC_HUMAN (P49588)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
AARS

# Metabolic_Enzyme_3_Geneatlas_id:
AARS

# Metabolic_Enzyme_3_hgnc_id:
HGNC:20

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm (Potential)

# Metabolic_Enzyme_3_Gene_Sequence:
>2907 bp
ATGGACTCTACTCTAACAGCAAGTGAAATCCGGCAGCGATTTATAGATTTCTTCAAGAGG
AACGAGCATACGTATGTTCACTCGTCTGCCACCATCCCATTGGATGACCCCACTTTGCTC
TTTGCCAATGCAGGCATGAACCAGTTTAAACCCATTTTCCTGAACACAATTGACCCATCT
CACCCCATGGCAAAGCTGAGCAGAGCTGCCAATACCCAGAAGTGCATCCGGGCTGGGGGC
AAACAAAATGACCTGGACGATGTGGGCAAGGATGTCTATCATCACACCTTCTTCGAGATG
CTGGGCTCTTGGTCTTTTGGAGATTACTTTAAGGAATTGGCATGTAAGATGGCTCTGGAA
CTCCTCACCCAAGAGTTTGGCATTCCCATTGAAAGACTTTATGTTACTTACTTTGGCGGG
GATGAAGCAGCTGGCTTAGAAGCAGATCTGGAATGCAAACAGATCTGGCAAAATTTGGGG
CTGGATGACACCAAAATCCTCCCAGGCAACATGAAGGATAACTTCTGGGAGATGGGTGAC
ACGGGCCCCTGTGGTCCTTGCAGTGAGATCCACTACGACCGGATTGGTGGTCGGGACGCC
GCACATCTTGTCAACCAGGACGACCCTAATGTGCTGGAGATCTGGAACCTTGTGTTCATC
CAGTATAACAGGGAAGCTGATGGCATTCTGAAACCTCTTCCCAAGAAAAGCATTGACACA
GGGATGGGCCTGGAACGACTGGTATCTGTGCTGCAGAATAAGATGTCCAACTATGACACT
GACCTTTTTGTCCCTTACTTTGAAGCCATTCAGAAGGGCACAGGTGCCCGACCATACACT
GGGAAAGTTGGTGCTGAGGATGCCGATGGGATTGACATGGCCTACCGGGTGCTGGCTGAC
CATGCTCGGACCATCACTGTGGCACTGGCTGATGGTGGCCGGCCTGACAACACAGGGCGT
GGATATGTGTTGAGACGGATTCTCCGCCGAGCTGTCCGATACGCCCATGAAAAGCTCAAT
GCCAGCAGGGGCTTCTTTGCTACGTTAGTGGATGTTGTCGTCCAGTCCCTGGGAGATGCA
TTTCCTGAGCTGAAGAAGGACCCAGACATGGTGAAGGACATCATTAATGAAGAAGAGGTG
CAGTTTCTCAAGACTCTCAGCAGAGGGCGTCGCATCCTGGACAGGAAAATTCAGAGCCTG
GGAGACAGCAAGACCATTCCCGGAGACACTGCTTGGCTCCTCTATGACACCTATGGGTTT
CCAGTGGATCTGACTGGACTGATTGCTGAAGAGAAGGGCCTGGTGGTAGACATGGATGGC
TTTGAAGAGGAGAGGAAACTGGCCCAGCTGAAATCACAGGGCAAGGGAGCTGGTGGGGAA
GACCTCATTATGCTGGACATTTACGCTATCGAAGAGCTCCGGGCACGGGGTCTGGAGGTC
ACAGATGATTCCCCAAAGTACAATTACCATTTGGACTCCAGTGGTAGCTATGTATTTGAG
AACACAGTGGCTACGGTGATGGCTCTGCGCAGGGAGAAGATGTTCGTGGAAGAGGTGTCC
ACAGGCCAGGAGTGTGGAGTGGTGCTGGACAAGACCTGTTTCTATGCTGAGCAAGGAGGC
CAGATCTATGACGAAGGCTACCTGGTGAAGGTGGATGACAGCAGTGAAGATAAAACAGAG
TTTACAGTGAAGAATGCTCAGGTCCGAGGAGGGTATGTGCTACACATTGGAACCATCTAC
GGTGACCTGAAAGTGGGGGATCAGGTCTGGCTGTTTATTGATGAGCCCCGACGAAGACCC
ATCATGAGCAACCACACAGCTACGCACATTCTGAACTTCGCCCTGCGCTCAGTGCTTGGG
GAAGCTGACCAGAAAGGCTCATTGGTTGCTCCTGACCGCCTCAGATTTGACTTTACTGCC
AAGGGAGCCATGTCCACCCAACAGATCAAGAAGGCTGAAGAGATTGCTAATGAGATGATT
GAGGCAGCCAAGGCCGTCTATACCCAGGATTGCCCCCTGGCAGCAGCGAAAGCCATCCAG
GGCCTACGGGCTGTGTTTGATGAGACCTATCCTGACCCTGTGCGAGTCGTCTCCATTGGG
GTCCCGGTGTCCGAGTTGCTGGATGACCCCTCTGGGCCTGCTGGCTCCCTGACTTCTGTT
GAGTTCTGTGGGGGAACGCACCTGCGGAACTCGAGTCATGCAGGAGCTTTTGTGATCGTG
ACGGAAGAAGCCATTGCCAAGGGTATCCGGAGGATTGTGGCTGTCACAGGTGCCGAGGCC
CAGAAGGCCCTCAGGAAAGCAGAGAGCTTGAAGAAATGTCTCTCTGTCATGGAAGCCAAA
GTGAAGGCTCAGACTGCTCCAAACAAGGATGTGCAGAGGGAGATCGCTGACCTTGGAGAG
GCCCTGGCCACTGCAGTCATCCCCCAGTGGCAGAAGGATGAATTGCGGGAGACTCTCAAA
TCCCTAAAGAAGGTCATGGATGACTTGGACCGAGCCAGCAAAGCCGATGTCCAGAAACGA
GTGTTAGAGAAGACGAAGCAGTTCATCGACAGCAACCCCAACCAGCCTCTTGTCATCCTG
GAGATGGAGAGCGGCGCCTCAGCCAAGGCCCTGAATGAAGCCTTGAAGCTCTTCAAGATG
CACTCCCCTCAGACTTCTGCCATGCTCTTCACGGTGGACAATGAGGCTGGCAAGATCACG
TGCCTGTGTCAAGTCCCCCAGAATGCAGCCAATCGGGGCTTAAAAGCCAGCGAGTGGGTG
CAGCAGGTGTCAGGCTTGATGGACGGTAAAGGTGGTGGCAAGGATGTGTCTGCACAGGCC
ACAGGCAAGAACGTTGGCTGCCTGCAGGAGGCGCTGCAGCTGGCCACTTCCTTCGCCCAG
CTGCGCCTCGGGGATGTAAAGAACTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
D32050

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
7654687; 10508479

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5561

# Metabolic_Enzyme_4_Name:
Kynureninase

# Metabolic_Enzyme_4_Synonyms:
L-kynurenine hydrolase

# Metabolic_Enzyme_4_Gene_Name:
KYNU

# Metabolic_Enzyme_4_Protein_Sequence:
>Kynureninase
MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLS
LVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLM
KDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHG
LNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAG
QAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKP
ALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKK
SVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEK
RGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN

# Metabolic_Enzyme_4_Number_of_Residues:
465

# Metabolic_Enzyme_4_Molecular_Weight:
52352

# Metabolic_Enzyme_4_Theoretical_pI:
7.04

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid carbon-carbon bonds
Function:  hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances
Function:  kynureninase activity
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
 ||
>>>
Process:  cofactor metabolism
Process:  coenzyme metabolism
Process:  coenzyme biosynthesis
Process:  pyridine nucleotide biosynthesis
Process:  NAD biosynthesis
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  indolalkylamine metabolism
Process:  tryptophan metabolism
Process:  tryptophan catabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_4_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic (AA) and 3- hydroxyanthranilic acids (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity

# Metabolic_Enzyme_4_Pathway:
map00380  Tryptophan metabolism

# Metabolic_Enzyme_4_Reaction:
L-kynurenine + H2O = anthranilate + L-alanine

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00266:Aminotran_5

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.7.1.3

# Metabolic_Enzyme_4_GenBank_ID_Protein:
1323715

# Metabolic_Enzyme_4_SwissProt_ID:
KYNU_HUMAN (Q16719)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
KYNU

# Metabolic_Enzyme_4_Geneatlas_id:
KYNU

# Metabolic_Enzyme_4_hgnc_id:
HGNC:6469

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_4_Gene_Sequence:
>1398 bp
ATGGAGCCTTCATCTCTTGAGCTGCCGGCTGACACAGTGCAGCGCATTGCGGCTGAACTC
AAATGCCACCCAACGGATGAGAGGGTGGCTCTCCACCTAGATGAGGAAGATAAGCTGAGG
CACTTCAGGGAGTGCTTTTATATTCCCAAAATACAGGATCTGCCTCCAGTTGATTTATCA
TTAGTGAATAAAGATGAAAATGCCATCTATTTCTTGGGAAATTCTCTTGGCCTTCAACCA
AAAATGGTTAAAACATATCTTGAAGAAGAACTAGATAAGTGGGCCAAAATAGCAGCCTAT
GGTCATGAAGTGGGGAAGCGTCCTTGGATTACAGGAGATGAGAGTATTGTAGGCCTTATG
AAGGACATTGTAGGAGCCAATGAGAAAGAAATAGCCCTAATGAATGCTTTGACTGTAAAT
TTACATCTTCTAATGTTATCATTTTTTAAGCCTACGCCAAAACGATATAAAATTCTTCTA
GAAGCCAAAGCCTTCCCTTCTGATCATTATGCTATTGAGTCACAACTACAACTTCACGGA
CTTAACATTGAAGAAAGTATGCGGATGATAAAGCCAAGAGAGGGGGAAGAAACCTTAAGA
ATAGAGGATATCCTTGAAGTAATTGAGAAGGAAGGAGACTCAATTGCAGTGATCCTGTTC
AGTGGGGTGCATTTTTACACTGGACAGCACTTTAATATTCCTGCCATCACAAAAGCTGGA
CAAGCGAAGGGTTGTTATGTTGGCTTTGATCTAGCACATGCAGTTGGAAATGTTGAACTC
TACTTACATGACTGGGGAGTTGATTTTGCCTGCTGGTGTTCCTACAAGTATTTAAATGCA
GGAGCAGGAGGAATTGCTGGTGCCTTCATTCATGAAAAGCATGCCCATACGATTAAACCT
GCATTAGTGGGATGGTTTGGCCATGAACTCAGCACCAGATTTAAGATGGATAACAAACTG
CAGTTAATCCCTGGGGTCTGTGGATTCCGAATTTCAAATCCTCCCATTTTGTTGGTCTGT
TCCTTGCATGCTAGTTTAGAGATCTTTAAGCAAGCGACAATGAAGGCATTGCGGAAAAAA
TCTGTTTTGCTAACTGGCTATCTGGAATACCTGATCAAGCATAACTATGGCAAAGATAAA
GCAGCAACCAAGAAACCAGTTGTGAACATAATTACTCCGTCTCATGTAGAGGAGCGGGGG
TGCCAGCTAACAATAACATTTTCTGTTCCAAACAAAGATGTTTTCCAAGAACTAGAAAAA
AGAGGAGTGGTTTGTGACAAGCGGAATCCAAATGGCATTCGAGTGGCTCCAGTTCCTCTC
TATAATTCTTTCCATGATGTTTATAAATTTACCAATCTGCTCACTTCTATACTTGACTCT
GCAGAAACAAAAAATTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
U57721

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_4_Locus:
2q22.2

# Metabolic_Enzyme_4_SNPs:
rs9013; rs16858205; rs6743085; rs1439876; rs1439875; rs1050950; rs10496935; rs2278587; rs7586571; rs4662304; rs6429989; rs16858172; rs16858198; rs10168358; rs1050951; rs10496936; rs12474554; rs16858175; rs10496937; rs16858196; rs352889; rs463427; rs181211; rs902924; rs352892; rs168476; rs407867; rs351673; rs351676; rs351685; rs1438266; rs351701; rs168475; rs164735; rs960822; rs351675; rs351696; rs1561566; rs351672; rs1371516; rs7573514; rs6710765; rs2452477; rs9917291; rs1388974; rs2381356; rs351674; rs7422912; rs6429995; rs164734; rs3768849; rs2304700; rs7607734; rs6711280; rs7561260; rs1012875; rs12463750; rs7598467; rs6430001; rs351678; rs11904225; rs6734849; rs352922; rs2083373; rs187090; rs6755074; rs6429997; rs13009680; rs6429994; rs432693; rs351693; rs3768853; rs352874; rs375704; rs3768850; rs164605; rs352925; rs352923; rs352930; rs1866619; rs351671; rs1371514; rs351692; rs10928159; rs12998182; rs352873; rs352885; rs3768844; rs16855235; rs11902056; rs10496934; rs17808482; rs2083374; rs4662187; rs6429991; rs3768851; rs6732064; rs164736; rs10496939; rs11902161; rs11685496; rs351684; rs6429998; rs7559471; rs7564245; rs12475145; rs17805075; rs351712; rs4662305; rs16855215; rs6705547; rs3820754; rs10496940; rs351695; rs7598811; rs444863; rs6742644; rs352890; rs13008636; rs13034563; rs6429990; rs11888124; rs6739188; rs4609990; rs12466715; rs13008447; rs7425446; rs351681; rs16855227; rs10184008; rs164732; rs351690; rs352888; rs351698; rs2099623; rs10179354; rs11902598; rs1948412; rs2043944; rs6732911; rs12997823; rs2008533; rs10496938; rs16858223; rs12053522; rs16858537; rs6728255; rs1371515; rs352929; rs7599405; rs16858418; rs12477146; rs11690108; rs6754283; rs16858402; rs10176234; rs6716587; rs351694; rs617158; rs352887; rs351689; rs6761184; rs11903769; rs1866620; rs11692509; rs2083189; rs189505; rs351691; rs13018862; rs3768848; rs3845642; rs7562371; rs352891; rs10496933; rs11686073; rs9917201; rs352894; rs7557827; rs1439874; rs7599490; rs16858494; rs352898; rs12992122; rs6429993; rs13393769; rs16858506; rs10184722; rs351710; rs16858414; rs17805827; rs16858209; rs351699; rs6755118; rs351679; rs7600006; rs12467638; rs352896; rs351704; rs3768854; rs11896948; rs11678485; rs12473966; rs13035454; rs16858406; rs16858497; rs378948; rs351677; rs7421765; rs975021; rs351682; rs6758612; rs352926; rs10210451; rs13001624; rs351688; rs17193842; rs352899; rs13024113; rs6739642; rs16858404; rs6429992; rs6430000; rs12465744; rs352900; rs13000671; rs6714694; rs3768847; rs10928160; rs11891470; rs10200188; rs1845049; rs352897; rs34550924; rs10195200; rs351686; rs16855223; rs352924; rs7424573; rs352931; rs13007794; rs13010597; rs351708; rs6743096; rs351709; rs17281006; rs7564368; rs12614982; rs352927; rs6728443; rs6716717; rs1561567; rs13030111; rs6429999; rs16858410; rs16858359; rs12469290; rs6741488; rs7588359; rs12474744; rs11678380; rs352893; rs164731; rs2043931; rs16858379; rs6710666; rs16858432; rs16858206; rs420328; rs352886; rs12993448; rs7599220; rs13006799; rs4662193; rs13025176; rs351683; rs352863; rs16858393; rs10928162; rs352895; rs2118581; rs12998116; rs16858279; rs17808140; rs352932; rs11903737; rs17193961; rs351707; rs16858449; rs352928; rs17808000; rs11692287; rs16858291; rs455827; rs694239; rs351711; rs12463485; rs16858510; rs168443; rs12620051; rs970171; rs351680; rs10199416; rs6748796; rs9751704; rs966320; rs12466617; rs7581211; rs16858429; rs16858309; rs2381355; rs10928161; rs11678473; rs351700; rs351687; rs425353; rs1001113; rs2016775; rs1465839; rs3816193; rs3806485; rs718208; rs13019411; rs1000644; rs2304705; rs4619541; rs35246097; rs35471528; rs4284771; rs13008592; rs6735204; rs35919402; rs12987959; rs35098353; rs34788193; rs10555200; rs10198815; rs13034741; rs34903547; rs35138381; rs2643; rs10207390; rs13034768; rs13034410; rs5834924; rs34845380; rs463252; rs35568578; rs35712587; rs6751792; rs28813415; rs3754603; rs34870922; rs1826422; rs36105324; rs423008; rs13008421; rs3068478; rs36033406; rs28826981; rs3069669; rs13027766; rs6709790; rs352862; rs34676277; rs10635189; rs3069632; rs34339654; rs7425707; rs11284689; rs35167272; rs28864073; rs6734299; rs6756023; rs35345901; rs10666932; rs35202501; rs17193168; rs5834926; rs6709193; rs12999277; rs34920245; rs28482960; rs28804822; rs6756643; rs6714380; rs6729435; rs41269813; rs3835779; rs5834931; rs35046471; rs34926526; rs6752886; rs13034980; rs11433429; rs13027986; rs13008244; rs34774136; rs351705; rs12995422; rs35178569; rs11321113; rs35955070; rs432289; rs1027272; rs2381398; rs17192994; rs34285056; rs7585286; rs7570195; rs35408439; rs34140211; rs28769327; rs352864; rs13035026; rs34396759; rs34929831; rs189527; rs34204027; rs28394047; rs35162584; rs5834923; rs34706877; rs375739; rs11900423; rs6737215; rs34840080; rs12990543; rs11274854; rs34279914; rs6709316; rs13032888; rs424960; rs6732770; rs36211208; rs36064230; rs34569631; rs35881126; rs33999951; rs34905937; rs35115029; rs1845047; rs28569933; rs35854733; rs34288977; rs34965832; rs6727335; rs5834928; rs33957496; rs10584849; rs36161758; rs7571909; rs420833; rs34445806; rs12988171; rs10660939; rs373523; rs13423803; rs36102969; rs13427560; rs458398; rs6713123; rs1688992; rs34163854; rs35968476; rs7599896; rs13382394; rs9679256; rs3098612; rs1602715; rs4404215; rs351702; rs352884; rs35128491; rs351697; rs10179341; rs34332680; rs34891373; rs41349548; rs13028569; rs13006690; rs34466499; rs35554808; rs35861813; rs4662310; rs10177321; rs35534229; rs4008370; rs4606865; rs396779; rs35008823; rs35577220; rs35404206; rs36000306; rs34404200; rs35991933; rs12472023; rs4318336; rs6748173; rs13401468; rs11454554; rs12999109; rs5834925; rs12996910; rs28872895; rs10184787; rs35434351; rs13387302; rs5834930; rs12463422; rs34071455; rs34035427; rs34077288; rs454467; rs35489784; rs35886408; rs11296598; rs12473916; rs351706; rs7597635; rs35581968; rs33918252; rs399540; rs7581761; rs3834108; rs13011324; rs5834929; rs13394445; rs28507047; rs13430660; rs28740878; rs4662307; rs2639460; rs11365726; rs7573059; rs6746980; rs28640876; rs34082230; rs4662191; rs28379752; rs34330315; rs34806486; rs411749; rs5834927; rs6711960; rs876728; rs34291445; rs11416939; rs10176027; rs35067548; rs10660938; rs13015113; rs12988163; rs35059103; rs13024702; rs34860771; rs193269; rs10673371; rs11347870; rs34574070; rs3835780; rs35690391; rs352901; rs430399; rs35202991; rs4662192; rs189526; rs7595058; rs351703; rs13399802; rs1845048; rs1561568; rs6761885; rs35906334; rs34725137; rs35480413; rs450544; rs11324914; rs7586452; rs6709334; rs34173054; rs6752885; rs28859939; rs4408670; rs34804412; rs4662306; rs11889838; rs6704916; rs34796957; rs35861691; rs1845046; rs34205416; rs164733; rs16858532; rs36114206; rs13400110; rs10697675; rs16858522; rs34718911; rs35954716; rs35740930; rs34956078; rs35749211; rs13019625; rs34148859; rs13025028; rs13034186; rs10650584; rs28820868; rs5834932; rs10528472; rs10597084; rs6740274; rs35512763; rs16858170; rs10166423; rs10172102; rs13007816; rs13426510; rs187134; rs2164910; rs354684; rs354687; rs7568663; rs7581038; rs7584890; rs7585123; rs967840; rs977033

# Metabolic_Enzyme_4_General_References:
8706755; 9180257

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
6131

# Metabolic_Enzyme_5_Name:
Alanine aminotransferase 1

# Metabolic_Enzyme_5_Synonyms:
ALT1; Glutamic--pyruvic transaminase 1; GPT 1; Glutamic--alanine transaminase 1

# Metabolic_Enzyme_5_Gene_Name:
GPT

# Metabolic_Enzyme_5_Protein_Sequence:
>Alanine aminotransferase 1
MASSTGDRSQAVRHGLRAKVLTLDGMNPRVRRVEYAVRGPIVQRALELEQELRQGVKKPF
TEVIRANIGD
AQAMGQRPITFLRQVLALCVNPDLLSSPNFPDDAKKRAERILQACGGHS
LGAYSVSSGIQLIREDVARYI
ERRDGGIPADPNNVFLSTGASDAIVTVLKLLVAGEGHT
RTGVLIPIPQYPLYSATLAELGAVQVDYYLDE
ERAWALDVAELHRALGQARDHCRPRAL
CVINPGNPTGQVQTRECIEAVIRFAFEERLFLLADEVYQDNVY
AAGSQFHSFKKVLMEM
GPPYAGQQELASFHSTSKGYMGECGFRGGYVEVVNMDAAVQQQMLKLMSVRLCP
PVPGQ
ALLDLVVSPPAPTDPSFAQFQAEKQAVLAELAAKAKLTEQVFNEAPGISCNPVQGAMYSF
PRVQL
PPRAVERAQELGLAPDMFFCLRLLEETGICVVPGSGFGQREGTYHFRMTILPPL
EKLRLLLEKLSRFHAK
FTLEYS

# Metabolic_Enzyme_5_Number_of_Residues:
496

# Metabolic_Enzyme_5_Molecular_Weight:
54638

# Metabolic_Enzyme_5_Theoretical_pI:
7.20

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-sulfur lyase activity
Function:  1-aminocyclopropane-1-carboxylate synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles

# Metabolic_Enzyme_5_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00710  Carbon fixation

# Metabolic_Enzyme_5_Reaction:
L-alanine + 2-oxoglutarate = pyruvate + L-glutamate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.6.1.2

# Metabolic_Enzyme_5_GenBank_ID_Protein:
1763096

# Metabolic_Enzyme_5_SwissProt_ID:
ALAT1_HUMAN (P24298)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
GPT

# Metabolic_Enzyme_5_Geneatlas_id:
GPT

# Metabolic_Enzyme_5_hgnc_id:
HGNC:4552

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1491 bp

ATGGCCTCGAGCACAGGTGACCGGAGCCAGGCGGTGAGGCATGGACTGAGGGCGAAGGT
GCTGACGCTGG
ACGGCATGAACCCGCGTGTGCGGAGAGTGGAGTACGCAGTGCGTGGCC
CCATAGTGCAGCGAGCCTTGGA
GCTGGAGCAGGAGCTGCGCCAGGGTGTGAAGAAGCCT
TTCACCGAGGTCATCCGTGCCAACATCGGGGAC
GCACAGGCTATGGGGCAGAGGCCCAT
CACCTTCCTGCGCCAGGTCTTGGCCCTCTGTGTTAACCCTGATC
TTCTGAGCAGCCCCA
ACTTCCCTGACGATGCCAAGAAAAGGGCGGAGCGCATCTTGCAGGCGTGTGGGGG
CCAC
AGTCTGGGGGCCTACAGCGTCAGCTCCGGCATCCAGCTGATCCGGGAGGACGTGGCGCGG
TACATT
GAGAGGCGTGACGGAGGCATCCCTGCGGACCCCAACAACGTCTTCCTGTCCAC
AGGGGCCAGCGATGCCA
TCGTGACGGTGCTGAAGCTGCTGGTGGCCGGCGAGGGCCACA
CACGCACGGGTGTGCTCATCCCCATCCC
CCAGTACCCACTCTACTCGGCCACGCTGGCA
GAGCTGGGCGCAGTGCAGGTGGATTACTACCTGGACGAG
GAGCGTGCCTGGGCGCTGGA
CGTGGCCGAGCTTCACCGTGCACTGGGCCAGGCGCGTGACCACTGCCGCC
CTCGTGCGC
TCTGTGTCATCAACCCTGGCAACCCCACCGGGCAGGTGCAGACCCGCGAGTGCATCGAGG
C
CGTGATCCGCTTCGCCTTCGAAGAGCGGCTCTTTCTGCTGGCGGACGAGGTGTACCAG
GACAACGTGTAC
GCCGCGGGTTCGCAGTTCCACTCATTCAAGAAGGTGCTCATGGAGAT
GGGGCCGCCCTACGCCGGGCAGC
AGGAGCTTGCCTCCTTCCACTCCACCTCCAAGGGCT
ACATGGGCGAGTGCGGGTTCCGCGGCGGCTATGT
GGAGGTGGTGAACATGGACGCTGCA
GTGCAGCAGCAGATGCTGAAGCTGATGAGTGTGCGGCTGTGCCCG
CCGGTGCCAGGACA
GGCCCTGCTGGACCTGGTGGTCAGCCCGCCCGCGCCCACCGACCCCTCCTTTGCGC
AGT
TCCAGGCTGAGAAGCAGGCAGTGCTGGCAGAGCTGGCGGCCAAGGCCAAGCTCACCGAGC
AGGTCTT
CAATGAGGCTCCTGGCATCAGCTGCAACCCAGTGCAGGGCGCCATGTACTCC
TTCCCGCGCGTGCAGCTG
CCCCCGCGGGCGGTGGAGCGCGCTCAGGAGCTGGGCCTGGC
CCCCGATATGTTCTTCTGCCTGCGCCTCC
TGGAGGAGACCGGCATCTGCGTGGTGCCAG
GGAGCGGCTTTGGGCAGCGGGAAGGCACCTACCACTTCCG
GATGACCATTCTGCCCCCC
TTGGAGAAACTGCGGCTGCTGCTGGAGAAGCTGAGCAGGTTCCATGCCAAG
TTCACCCT
CGAGTACTCCTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U70732

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_5_Locus:
8q24.3

# Metabolic_Enzyme_5_SNPs:
Not Available

# Metabolic_Enzyme_5_General_References:
9119391; 1931970; 11863375

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
6146

# Metabolic_Enzyme_6_Name:
N-acetylmuramoyl-L-alanine amidase precursor

# Metabolic_Enzyme_6_Synonyms:
Peptidoglycan recognition protein long; PGRP-L; Peptidoglycan recognition protein 2

# Metabolic_Enzyme_6_Gene_Name:
PGLYRP2

# Metabolic_Enzyme_6_Protein_Sequence:
>NacetylmuramoylLalanine amidase precursor
MAQGVLWILLGLLLWSDPGTASLPLLMDSVIQALAELEQKVPAAKTRHTASAWLMSAPNS
GPHNRLYHFLLGAWSLNATELDPCPLSPELLGLTKEVARHDVREGKEYGVVLAPDGSTVA
VEPLLAGLEAGLQGRRVINLPLDSMAAPWETGDTFPDVVAIAPDVRATSSPGLRDGSPDV
TTADIGANTPDATKGCPDVQASLPDAKAKSPPTMVDSLLAVTLAGNLGLTFLRGSQTQSH
PDLGTEGCWDQLSAPRTFTLLDPKASLLTMAFLNGALDGVILGDYLSRTPEPRPSLSHLL
SQYYGAGVARDPGFRSNFRRQNGAALTSASILAQQVWGTLVLLQRLEPVHLQLQCMSQEQ
LAQVAANATKEFTEAFLGCPAIHPRCRWGAAPYRGRPKLLQLPLGFLYVHHTYVPAPPCT
DFTRCAANMRSMQRYHQDTQGWGDIGYSFVVGSDGYVYEGRGWHWVGAHTLGHNSRGFGV
AIVGNYTAALPTEAALRTVRDTLPSCAVRAGLLRPDYALLGHRQLVRTDCPGDALFDLLR
TWPHFTATVKPRPARSVSKRSRREPPPRTLPATDLQ

# Metabolic_Enzyme_6_Number_of_Residues:
576

# Metabolic_Enzyme_6_Molecular_Weight:
62218

# Metabolic_Enzyme_6_Theoretical_pI:
7.59

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Function:  N-acetylmuramoyl-L-alanine amidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  cellular carbohydrate metabolism
Process:  peptidoglycan metabolism
Process:  peptidoglycan catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity

# Metabolic_Enzyme_6_Pathway:
map00550  Peptidoglycan biosynthesis

# Metabolic_Enzyme_6_Reaction:
Hydrolyses the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF01510:Amidase_2

# Metabolic_Enzyme_6_Signals:
1-21

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.5.1.28

# Metabolic_Enzyme_6_GenBank_ID_Protein:
15705411

# Metabolic_Enzyme_6_SwissProt_ID:
PGRP2_HUMAN (Q96PD5)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
PGLYRP2

# Metabolic_Enzyme_6_Geneatlas_id:
PGLYRP2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:30013

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Secreted protein. Membrane

# Metabolic_Enzyme_6_Gene_Sequence:
>1731 bp
ATGGCCCAGGGTGTCCTCTGGATCCTACTCGGATTGCTACTGTGGTCAGACCCAGGGACA
GCCTCCCTGCCCCTGCTCATGGACTCTGTCATCCAGGCCCTGGCTGAGCTGGAGCAGAAA
GTGCCAGCTGCCAAGACCAGACACACAGCTTCTGCGTGGCTGATGTCAGCTCCAAACTCT
GGCCCCCACAATCGCCTCTACCACTTCCTGCTGGGGGCATGGAGCCTCAATGCTACAGAG
TTGGATCCCTGCCCACTAAGCCCAGAGCTGTTAGGCCTGACCAAGGAGGTGGCCCGACAT
GACGTACGAGAAGGGAAGGAATATGGGGTGGTGCTGGCACCTGATGGCTCGACCGTGGCT
GTGGAGCCTCTGCTGGCGGGGCTGGAGGCAGGGCTGCAAGGGCGCAGGGTCATAAATTTG
CCCTTGGACAGCATGGCTGCCCCTTGGGAGACTGGAGATACCTTTCCAGATGTTGTGGCC
ATTGCTCCAGATGTAAGAGCCACCTCCTCCCCAGGACTCAGGGATGGCTCTCCAGATGTC
ACCACTGCAGATATTGGAGCCAACACTCCAGATGCTACAAAAGGCTGTCCAGATGTCCAA
GCTTCCTTGCCAGATGCCAAAGCCAAGTCCCCACCGACCATGGTGGACAGCCTCCTGGCA
GTCACCCTGGCTGGAAACCTGGGCCTGACCTTCCTCCGAGGTTCCCAGACCCAGAGCCAT
CCAGACCTGGGAACTGAGGGCTGCTGGGACCAGCTCTCTGCCCCTCGGACCTTTACGCTT
TTGGACCCCAAGGCATCTCTGTTAACCATGGCCTTCCTCAATGGCGCCCTGGATGGGGTC
ATCCTTGGAGACTACCTGAGCCGGACTCCTGAGCCCCGGCCATCCCTCAGCCACTTGCTG
AGCCAGTACTATGGGGCTGGGGTGGCCAGAGACCCAGGGTTCCGCAGCAACTTCCGACGG
CAGAACGGTGCTGCTCTGACTTCAGCCTCCATCCTGGCCCAGCAGGTGTGGGGAACCCTT
GTCCTTCTACAGAGGCTGGAGCCAGTACACCTCCAGCTTCAGTGCATGAGCCAAGAACAG
CTGGCCCAGGTGGCTGCCAATGCTACCAAGGAATTCACTGAGGCCTTCCTGGGATGCCCG
GCCATCCACCCCCGCTGCCGCTGGGGAGCGGCGCCTTATCGGGGCCGCCCGAAGCTGCTG
CAGCTGCCGCTGGGATTCTTGTACGTGCATCACACCTACGTGCCTGCACCACCCTGCACG
GACTTCACGCGCTGCGCAGCCAACATGCGCTCCATGCAGCGCTACCACCAGGACACGCAA
GGCTGGGGAGACATCGGCTACAGTTTCGTGGTGGGCTCGGACGGCTACGTGTACGAGGGA
CGCGGCTGGCACTGGGTGGGCGCCCACACGCTCGGCCACAACTCCCGGGGCTTCGGCGTG
GCCATAGTGGGCAACTACACCGCGGCGCTGCCCACCGAGGCCGCTCTGCGCACGGTGCGC
GACACGCTCCCGAGTTGTGCGGTGCGCGCCGGCCTCCTGCGGCCAGACTACGCGCTGCTG
GGCCACCGCCAGCTGGTGCGCACCGACTGCCCCGGCGACGCGCTCTTCGACCTGCTGCGC
ACCTGGCCGCACTTCACCGCGACTGTTAAGCCAAGACCTGCCAGGAGTGTCTCTAAGAGA
TCCAGGAGGGAGCCACCCCCAAGGACCCTGCCAGCCACAGACCTCCAATAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AF384856

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_6_Locus:
19p13.12

# Metabolic_Enzyme_6_SNPs:
rs733731; rs892145; rs3813135; rs28404490; rs35927052; rs35973013; rs11668144; rs1560727; rs8099840; rs959117; rs12610560; rs1961562; rs6512036; rs8105422; rs7248655; rs7252114; rs7245400; rs6512038; rs7251871; rs6512037; rs10413421; rs4264508; rs4638719; rs4808308; rs12609198; rs2366057; rs3813136; rs4808310; rs2116907; rs2116906; rs4808311; rs34440547; rs34865150; rs2304200; rs35662083; rs7258629; rs10417763; rs36020076; rs28799057; rs35203240; rs35039103; rs35857743; rs8110607; rs7257137; rs12971481; rs4808309; rs10164310; rs34640786; rs12979216; rs34586297; rs10048485; rs36085636; rs34358190; rs10417406; rs10411085; rs2163844; rs34294002; rs2116905; rs12974689; rs8104257; rs35973923; rs35038807; rs35514478; rs10410954; rs11085953; rs11666779; rs11881159; rs12974277; rs12982747; rs3764565; rs3764566; rs4450526; rs4809193

# Metabolic_Enzyme_6_General_References:
11461926; 12975309; 7663175; 12754519

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
8527

# Metabolic_Enzyme_7_Name:
Hypothetical protein SCLY

# Metabolic_Enzyme_7_Synonyms:
Not Available

# Metabolic_Enzyme_7_Gene_Name:
SCLY

# Metabolic_Enzyme_7_Protein_Sequence:
>Hypothetical protein 
SCLYMEAAVAPGRDAPAPAASQPSGCGKHNSPERKVYMDYNATTPLEPEVIQAMTKAMWE
AWGNPSSPYSAGRKAKDIINAARESLAKMIGGKPQDIIFTSGGTESNNLVIHSVVKHFHA
NQTSKGHTGGHHSPVKGAKPHFITSSVEHDSIRLPLEHLVEEQVAAVTFVPVSKVSGQAE
VDDILAAVRPTTRLVTIMLANNETGIVMPVPEISQRIKALNQERVAAGLPPILVHTDAAQ
ALGKQRVDVEDLGVDFLTIVGHKFYGPRIGALYIRGLGEFTPLYPMLFGGGQERNFRPG

# Metabolic_Enzyme_7_Number_of_Residues:
295

# Metabolic_Enzyme_7_Molecular_Weight:
31685

# Metabolic_Enzyme_7_Theoretical_pI:
7.92

# Metabolic_Enzyme_7_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Amino acid transport and metabolism

# Metabolic_Enzyme_7_Specific_Function:
Not Available

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
Not Available

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00266:Aminotran_5

# Metabolic_Enzyme_7_Signals:
Not Available

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 4.4.1.16

# Metabolic_Enzyme_7_GenBank_ID_Protein:
62988832

# Metabolic_Enzyme_7_SwissProt_ID:
Q53SN1_HUMAN (Q53SN1)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
SCLY

# Metabolic_Enzyme_7_Geneatlas_id:
SCLY

# Metabolic_Enzyme_7_hgnc_id:
HGNC:18161

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>884 bp
ATGGAGGCGGCCGTGGCGCCGGGGAGGGATGCGCCGGCACCCGCGGCGAGTCAGCCCAGC
GGCTGCGGGAAACACAACTCGCCGGAGAGGAAAGTTTATATGGACTATAATGCAACGACT
CCCCTGGAGCCAGAAGTTATCCAGGCCATGACCAAGGCCATGTGGGAAGCCTGGGGAAAT
CCCAGCAGCCCGTATTCAGCAGGAAGAAAGGCCAAGGATATTATAAATGCAGCTCGGGAA
AGCCTCGCGAAGATGATAGGGGGGAAACCTCAAGATATAATCTTCACTTCCGGGGGCACT
GAGTCAAATAATTTAGTAATCCATTCTGTGGTGAAACATTTCCACGCAAACCAGACCTCA
AAGGGACACACAGGTGGGCACCACAGCCCAGTGAAGGGGGCCAAGCCCCATTTCATTACT
TCCTCGGTGGAACACGACTCCATCCGGCTGCCCCTGGAGCACCTGGTGGAAGAACAAGTG
GCAGCGGTCACCTTTGTCCCGGTGTCCAAGGTGAGCGGGCAGGCAGAGGTGGACGACATC
CTCGCGGCAGTCCGCCCGACCACACGCCTCGTGACCATCATGCTGGCCAACAATGAGACT
GGCATTGTCATGCCTGTCCCTGAAATCAGTCAGCGCATTAAAGCCCTGAACCAGGAACGG
GTGGCAGCTGGGCTACCTCCCATCCTCGTGCACACGGATGCTGCACAGGCCTTGGGGAAG
CAGCGCGTGGATGTGGAGGACCTGGGCGTGGACTTCCTTACAATCGTGGGGCACAAGTTT
TATGGTCCCAGGATTGGCGCACTTTATATACGAGGACTTGGTGAATTTACCCCTCTCTAC
CCTATGCTATTTGGAGGTGGACAAGAACGGAATTTCAGGCCAGG

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AC016776

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_7_Locus:
2q37.3

# Metabolic_Enzyme_7_SNPs:
rs7597367; rs3210400; rs35637307; rs1128552; rs12993309; rs821480; rs2264133; rs2248837; rs821483; rs2248623; rs2278742; rs2249434; rs2249435; rs2249077; rs1374386; rs7587303; rs2262425; rs2252416; rs2249540; rs2243417; rs2249674; rs2249668; rs3739051; rs2278743; rs7591078; rs3769109; rs2249283; rs2249543; rs821481; rs6720524; rs7600907; rs17069; rs2264132; rs13391701; rs11682046; rs11673954; rs10929264; rs12622481; rs4663836; rs2262426; rs2249173; rs2326009; rs2250185; rs7563539; rs3739055; rs2252328; rs2249067; rs3739057; rs7579980; rs3739056; rs13398615; rs6733588; rs12478599; rs12475091; rs10208591; rs2441680; rs11680851; rs2248836; rs2264166; rs13014837; rs13400062; rs2250038; rs11678642; rs12619160; rs9808062; rs11685392; rs13382432; rs12618952; rs7601010; rs7605671; rs9808016; rs10194344; rs11692968; rs2262615; rs1374479; rs2243545; rs35544137; rs34720560; rs34735392; rs34522626; rs2248824; rs34627467; rs13390449; rs13384319; rs34798549; rs2252822; rs35234986; rs35222550; rs2290013; rs11285079; rs36068737; rs13002901; rs34461284; rs11695712; rs34118873; rs3052465; rs13388834; rs11335455; rs2248825; rs2592585; rs6716105; rs2250045; rs41270749; rs34975994; rs34951361; rs34726652; rs34015663; rs34824252; rs34049050; rs13024836; rs13406372; rs34608617; rs35156212; rs821482; rs34622750; rs34782377; rs2718; rs13424865; rs3052488; rs35023607; rs35939779; rs34604892; rs3054528; rs34425065; rs13395126; rs35947164; rs13409062; rs35551907; rs35598497; rs34281874; rs35350592; rs35961987; rs34106838; rs2250039; rs11678255; rs3845676; rs2592583; rs35166091; rs34472497; rs7569765; rs36119390; rs10198137; rs35024616; rs2262616; rs13385539; rs13033964; rs35898194; rs34914609; rs34390699; rs34265211; rs3835105; rs4328587; rs10533305; rs35336034; rs13390555; rs2441476; rs11397122; rs13415013; rs34116547; rs1006300; rs10186290; rs10199495; rs10210979; rs1054640; rs1054641; rs11679560; rs12613823; rs13001553; rs13006807; rs13398792; rs1562333; rs1562337; rs15787; rs2121405; rs2121406; rs34046909; rs34483644; rs34878344; rs35324619; rs36066915; rs3816347; rs3816348; rs4663285; rs6728338; rs6728431; rs6728451; rs6754733; rs752990; rs7565244; rs7577089; rs7583402; rs821487; rs821489; rs843975; rs878133; rs878134; rs935413; rs935414; rs935415

# Metabolic_Enzyme_7_General_References:
Not Available

# Metabolic_Enzyme_7_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8479

# Macromolecular_Interacting_Partner_1_Name:
Asc-type amino acid transporter 1

# Macromolecular_Interacting_Partner_1_Synonyms:
Asc-1

# Macromolecular_Interacting_Partner_1_Gene_Name:
SLC7A10

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Asctype amino acid transporter 1
MAGHTQQPSGRGNPRPAPSPSPVPGTVPGASERVALKKEIGLLSACTIIIGNIIGSGIFI
SPKGVLEHSGSVGLALFVWVLGGGVTALGSLCYAELGVAIPKSGGDYAYVTEIFGGLAGF
LLLWSAVLIMYPTSLAVISMTFSNYVLQPVFPNCIPPTTASRVLSMACLMLLTWVNSSSV
RWATRIQDMFTGGKLLALSLIIGVGLLQIFQGHFEELRPSNAFAFWMTPSVGHLALAFLQ
GSFAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELLSSN
AVAVTFGEKLLGYFSWVMPVSVALSTFGGINGYLFTYSRLCFSGAREGHLPSLLAMIHVR
HCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLLLRWRRPALHRPI
KVNLLIPVAYLVFWAFLLVFSFISEPMVCGVGVIIILTGVPIFFLGVFWRSKPKCVHRLT
ESMTHWGQELCFVVYPQDAPEEEENGPCPPSLLPATDKPSKPQ

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
523

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
56799

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
8.24

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
 Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_1_Specific_Function:
Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_1_Signals:
1-136

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
40-60
72-92
113-133
268-288
310-330
362-382
388-408
424-444
448-468

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
9309293

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
AAA1_HUMAN (Q9NS82)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
SLC7A10

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
SLC7A10

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:11058

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; multi-pass membrane protein (Probable)

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1572 bp
ATGGCCGGCCACACGCAGCAGCCGAGCGGGCGCGGGAACCCCAGGCCTGCGCCCTCGCCC
TCCCCAGTCCCAGGGACCGTCCCCGGCGCCTCGGAGCGGGTGGCGCTCAAGAAGGAGATC
GGGCTGCTGAGCGCCTGCACCATCATCATCGGGAACATCATCGGCTCGGGCATCTTCATC
TCGCCCAAGGGGGTCCTGGAGCACTCAGGCTCCGTGGGTCTGGCCCTGTTCGTCTGGGTC
CTGGGTGGGGGCGTGACGGCTCTGGGCTCCCTCTGCTATGCAGAGCTGGGAGTCGCCATC
CCCAAGTCTGGCGGGGACTACGCCTACGTCACAGAGATCTTCGGGGGCCTGGCTGGCTTT
CTGCTGCTCTGGAGCGCCGTCCTCATCATGTACCCCACCAGCCTTGCTGTCATCTCCATG
ACCTTCTCCAACTACGTGCTGCAGCCCGTGTTCCCCAACTGCATCCCCCCCACCACAGCC
TCCCGGGTGCTGTCCATGGCCTGCCTGATGCTCCTGACATGGGTGAACAGCTCCAGTGTG
CGCTGGGCCACGCGCATCCAGGACATGTTCACAGGCGGGAAGCTGCTGGCCTTGTCCCTC
ATCATCGGCGTGGGCCTTCTCCAGATCTTCCAAGGACACTTCGAGGAGCTGAGGCCCAGC
AATGCCTTTGCTTTCTGGATGACGCCCTCCGTGGGACACCTGGCCCTGGCCTTCCTCCAG
GGCTCCTTCGCCTTCAGTGGCTGGAACTTCCTCAACTATGTCACCGAGGAGATGGTTGAC
GCCCGAAAGAACCTACCTCGCGCCATCTTCATCTCCATCCCACTGGTGACCTTCGTGTAC
ACGTTCACCAACATTGCCTACTTCACGGCCATGTCCCCCCAGGAGCTGCTCTCCTCCAAT
GCGGTGGCTGTGACCTTCGGGGAGAAGCTGCTGGGCTACTTTTCTTGGGTCATGCCTGTC
TCCGTGGCTCTGTCAACCTTCGGAGGGATCAATGGTTACCTGTTCACCTACTCCAGGCTG
TGCTTCTCTGGAGCCCGCGAGGGGCACCTGCCCAGCCTGCTGGCCATGATCCACGTCAGA
CACTGCACCCCCATCCCCGCCCTCCTCGTCTGTTGCGGGGCCACAGCCGTCATCATGCTC
GTGGGCGACACGTACACGCTCATCAACTATGTGTCCTTCATCAACTACCTCTGCTACGGC
GTCACCATCCTGGGCCTGCTGCTGCTGCGCTGGAGGCGGCCTGCACTCCACAGGCCCATC
AAGGTGAACCTTCTCATCCCCGTGGCGTACTTGGTCTTCTGGGCCTTCCTGCTGGTCTTC
AGCTTCATCTCAGAGCCTATGGTCTGTGGGGTCGGCGTCATCATCATCCTTACGGGGGTG
CCCATTTTCTTTCTGGGAGTGTTCTGGAGAAGCAAACCAAAGTGTGTGCACAGACTCACA
GAGTCCATGACACACTGGGGCCAGGAGCTGTGTTTCGTGGTCTACCCCCAGGACGCCCCC
GAAGAGGAGGAGAATGGCCCCTGCCCACCCTCCCTGCTGCCTGCCACAGACAAGCCCTCG
AAGCCACAATGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AB037670

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_1_Locus:
19q13.1

# Macromolecular_Interacting_Partner_1_SNPs:
rs34663170; rs2303094; rs4805031; rs7258412; rs12609177; rs8106493; rs1974807; rs10406787; rs8101891; rs7254894; rs12609763; rs7508758; rs3786926; rs2303093; rs8106375; rs4407170; rs3786927; rs2241378; rs8105889; rs11669156; rs1009175; rs11673535; rs16967863; rs11671790; rs34454261; rs8105887; rs12972369; rs11084715; rs4805030; rs4516343; rs8110876; rs35557280; rs16967861; rs12972468; rs11878801; rs11666788; rs10417375; rs726822; rs1465424; rs4330029; rs4553741; rs7251684; rs889102; rs7249980; rs35390810; rs11542481; rs34961684; rs8107888; rs12151336; rs11670702; rs34937345; rs34203180; rs889101; rs34180473; rs10555903; rs12982023; rs33951856; rs4805862; rs11882613; rs11879325; rs34981363; rs11378328; rs8107002; rs11880750; rs34309383; rs5827838; rs35763570; rs35887187; rs7248380; rs34843019; rs11455629; rs28419758; rs35055563; rs35775570; rs35756066; rs11671925; rs34257327; rs10667670; rs34645339; rs36212687; rs3064210; rs5827839; rs11448774; rs5827841; rs3064187; rs5827842; rs889103; rs36216474; rs10410558; rs10412342; rs1056034; rs1056041; rs1107920; rs1107921; rs11084712; rs11666900; rs11671345; rs11672303; rs11673115; rs1559182; rs17694094; rs17760699; rs17848212; rs1862464; rs2112800; rs2194169; rs2303095; rs2303096; rs34138351; rs34158692; rs34529542; rs35831673; rs36029918; rs3745974; rs3745975; rs3745976; rs3745977; rs3745978; rs4444444; rs4805863; rs7359893; rs8100642; rs875550

# Macromolecular_Interacting_Partner_1_General_References:
10863037; 11509015

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8518

# Macromolecular_Interacting_Partner_2_Name:
Proton-coupled amino acid transporter 1

# Macromolecular_Interacting_Partner_2_Synonyms:
Proton/amino acid transporter 1; Solute carrier family 36 member 1

# Macromolecular_Interacting_Partner_2_Gene_Name:
SLC36A1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Protoncoupled amino acid transporter 1
MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNSTTWFQTLIHLLKGN
IGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCAHHFCRRLNKSFVDYGDTV
MYGLESSPCSWLRNHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQVIEAANGTTNNC
HNNETVILTPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIV
QRIPDPSHLPLVAPWKTYPLFFGTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVT
ILYISLGCLGYLQFGANIQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIP
FFVSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLE
VTTFYSEGMSPLTIFKDALISILGFVGFVVGTYEALYELIQPSNAPIFINSTCAFI

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
476

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
53076

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
7.00

# Macromolecular_Interacting_Partner_2_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_2_Specific_Function:
Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_2_Signals:
1-216

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
52-72
79-99
142-162
191-211
216-236
258-278
290-310
343-363
373-393
398-418
440-460

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
31324239

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
S36A1_HUMAN (Q7Z2H8)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
SLC36A1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
SLC36A1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:18761

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cell membrane; multi-pass membrane protein. Lysosome; lysosomal membrane; multi-pass membrane protein (By similarity)

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1431 bp
ATGTCCACGCAGAGACTTCGGAATGAAGACTACCACGACTACAGCTCCACGGACGTGAGC
CCTGAGGAGAGCCCGTCGGAAGGCCTCAACAACCTCTCCTCCCCGGGCTCCTACCAGCGC
TTTGGTCAAAGCAATAGCACAACATGGTTCCAGACCTTGATCCACCTGTTAAAAGGCAAC
ATTGGCACAGGACTCCTGGGACTCCCTCTGGCGGTGAAAAATGCAGGCATCGTGATGGGT
CCCATCAGCCTGCTGATCATAGGCATCGTGGCCGTGCACTGCATGGGTATCCTGGTGAAA
TGTGCTCACCACTTCTGCCGCAGGCTGAATAAATCCTTTGTGGATTATGGTGATACTGTG
ATGTATGGACTAGAATCCAGCCCCTGCTCCTGGCTCCGGAACCACGCACACTGGGGAAGA
CGTGTTGTGGACTTCTTCCTGATTGTCACCCAGCTGGGATTCTGCTGTGTCTATTTTGTG
TTTCTGGCTGACAACTTTAAACAGGTGATAGAAGCGGCCAATGGGACCACCAATAACTGC
CACAACAATGAGACGGTGATTCTGACGCCTACCATGGACTCGCGACTCTACATGCTCTCC
TTCCTGCCCTTCCTGGTGCTGCTGGTTTTCATCAGGAACCTCCGAGCCCTGTCCATCTTC
TCCCTGTTGGCCAACATCACCATGCTGGTCAGCTTGGTCATGATCTACCAGTTCATTGTT
CAGAGGATCCCAGACCCCAGCCACCTCCCCTTGGTGGCCCCTTGGAAGACCTACCCTCTC
TTCTTTGGCACAGCGATTTTTTCATTTGAAGGCATTGGAATGGTTCTGCCCCTGGAAAAC
AAAATGAAGGATCCTCGGAAGTTCCCACTCATCCTGTACCTGGGCATGGTCATCGTCACC
ATCCTCTACATCAGCCTGGGGTGTCTGGGGTACCTGCAATTTGGAGCTAATATCCAAGGC
AGCATAACCCTCAACCTGCCCAACTGCTGGTTGTACCAGTCAGTTAAGCTGCTGTACTCC
ATCGGGATCTTTTTCACCTACGCACTCCAGTTCTACGTCCCGGCTGAGATCATCATCCCC
TTCTTTGTGTCCCGAGCGCCCGAGCACTGTGAGTTAGTGGTGGACCTGTTTGTGCGCACA
GTGCTGGTCTGCCTGACATGCATCTTGGCCATCCTCATCCTCCGCCTGGACCTGGTCATC
TCCCTGGTGGGCTCCGTGAGCAGCAGCGCCCTGGCCCTCATCATCCCACCGCTCCTGGAG
GTCACCACCTTCTACTCAGAGGGCATGAGCCCCCTCACCATCTTTAAGGACGCCCTGATC
AGCATCCTGGGCTTCGGGGGCTTTGGGGGGGGGACCTATGAGGCTCTCTATGAGCTGATC
CAGCCAAGCAATGCTCCCATCTTCATCAATTCCACCTGTGCCTTCATATAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AF516142

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_2_Locus:
5q33.1

# Macromolecular_Interacting_Partner_2_SNPs:
rs9687945; rs918421; rs6871593; rs12655145; rs7706041; rs723329; rs165370; rs6875844; rs729057; rs4958272; rs4958458; rs1175; rs7730595; rs17112008; rs165323; rs165369; rs6872051; rs17740674; rs11954054; rs10077304; rs14160; rs17802828; rs17717168; rs12654623; rs2278372; rs6868032; rs2278373; rs35060330; rs13362472; rs11950575; rs10074670; rs165353; rs165366; rs357620; rs165364; rs357616; rs2271215; rs152722; rs415426; rs165359; rs357618; rs165350; rs357619; rs165363; rs357628; rs357610; rs165352; rs165367; rs357617; rs7700762; rs165351; rs6892322; rs357627; rs165355; rs7729973; rs357624; rs6579877; rs357614; rs152392; rs7730542; rs357629; rs165365; rs357623; rs357611; rs357613; rs152391; rs357622; rs165357; rs7721225; rs11949709; rs357625; rs17112022; rs7715996; rs173349; rs357608; rs2271217; rs152390; rs152389; rs165358; rs165356; rs6891599; rs441652; rs13165298; rs165361; rs165354; rs7722725; rs151755; rs12109083; rs12108809; rs10476986; rs17112026; rs12652584; rs193299; rs12517705; rs17740853; rs181548; rs357621; rs2278374; rs357609; rs13177627; rs394736; rs165360; rs357630; rs357612; rs189615; rs6884262; rs165324; rs10067717; rs3905908; rs10060512; rs35204299; rs34807130; rs36112231; rs34668619; rs34075182; rs34478431; rs165368; rs35191954; rs1238148; rs3832373; rs34023473; rs1876621; rs33959674; rs6865892; rs35523611; rs13436718; rs10054849; rs1494538; rs36036885; rs10635760; rs10076469; rs35240570; rs35074529; rs33931867; rs5872207; rs35097474; rs7710891; rs11553685; rs34867392; rs400501; rs34306317; rs1494537; rs6868168; rs1644031; rs11435061; rs35256722; rs34814099; rs13155218; rs190360; rs34768974; rs34046389; rs34232698; rs35595732; rs10050844; rs6878589; rs28703169; rs35929969; rs11389317; rs35868592; rs13172953; rs11453209; rs35002039; rs165362; rs28625753; rs6860029; rs13355111; rs34928684; rs35727313; rs34320512; rs36220874; rs5872208; rs1047371; rs33918956; rs357626; rs10067276; rs11750448; rs1654089; rs6878344; rs3841626; rs36024368; rs34013133; rs28591205; rs11949963; rs11167548; rs35707638; rs35655674; rs11303709; rs34145742; rs35361647; rs33938062; rs187180; rs7729206; rs11427460; rs10067553; rs6869796; rs34114557; rs13164973; rs3830456; rs34920684; rs35854261; rs11281205; rs2271216; rs33974809; rs3086279; rs34249564; rs10648851; rs12332278; rs35901406; rs35132795; rs36039116; rs28400419; rs34757222; rs34517564; rs35461038; rs10637454; rs11279332; rs2278375; rs35783925; rs13359993; rs34965236; rs6875491; rs35220703; rs35474478; rs13357451; rs34688075; rs6860591; rs12109979; rs36232311; rs11459545; rs35330119; rs10042192; rs10664114; rs10709981; rs11959634; rs28557209; rs10079386; rs6877865; rs35791981; rs10040628; rs10042791; rs10043854; rs10054626; rs10075373; rs10476771; rs11951808; rs11956563; rs13180182; rs165325; rs165326; rs165327; rs165328; rs165329; rs165330; rs165331; rs165332; rs165333; rs165334; rs165335; rs1654090; rs17111998; rs17717506; rs17802804; rs1876620; rs2545666; rs34831908; rs357607; rs385255; rs393824; rs420486; rs4958457; rs6579878; rs6879238; rs6885230; rs7356707; rs7714380; rs9324696

# Macromolecular_Interacting_Partner_2_General_References:
12809675

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8531

# Macromolecular_Interacting_Partner_3_Name:
Low-affinity cationic amino acid transporter 2

# Macromolecular_Interacting_Partner_3_Synonyms:
CAT-2; CAT2

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC7A2

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Lowaffinity cationic amino acid transporter 2
MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA
KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI
LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLL
SFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENG
TSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCF
MAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPM
PRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLM
AYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLF
CPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAI
VLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFS
YGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
658

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
71674

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
7.31

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
 Function:  amino acid permease activity
Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
 Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_3_Specific_Function:
Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine)

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_3_Signals:
1-543

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
38-59
64-84
105-125
164-184
193-213
249-269
290-309
340-360
387-407
411-431
491-511
525-549
558-578
583-603

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
849051

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
CTR2_HUMAN (P52569)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC7A2

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC7A2

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:11060

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1977 bp
ATGATTCCTTGCAGAGCCGCGCTGACCTTTGCCCGATGTCTGATCCGGAGAAAAATCGTG
ACCCTGGACAGTCTAGAAGACACCAAATTATGCCGCTGCTTATCCACCATGGACCTCATT
GCCCTGGGCGTTGGAAGCACCCTTGGGGCCGGGGTTTATGTCCTCGCTGGGGAGGTGGCC
AAGGCAGACTCGGGCCCCAGCATCGTGGTGTCCTTCCTCATTGCTGCCCTGGCTTCAGTG
ATGGCTGGCCTCTGCTATGCCGAATTTGGGGCCCGTGTTCCCAAGACGGGGTCTGCATAT
TTGTACACCTACGTGACTGTCGGAGAGCTGTGGGCCTTCATCACTGGCTGGAATCTCATT
TTATCGTATGTGATAGGTACATCAAGTGTTGCAAGAGCCGGGAGTGGCACCTTTGATGAA
CTTCTTAGCAAACAGATTGGTCAGTTTTTGAGGACATACTTCAGAATGAATTACACTGGT
CTTGCAGAATATCCCGATTTTTTTGCTGTGTGCCTTATATTACTTCTAGCAGGTCTTTTG
TCTTTTGGAGTAAAAGAGTCTGCTTGGGTGAATAAAGTCTTCACAGCTGTTAATATTCTC
GTCCTTCTGTTTGTGATGGTTGCTGGGTTTGTGAAAGGAAATGTGGCAAACTGGAAGATT
AGTGAAGAGTTTCTCAAAAATATATCAGCAAGTGCCAGAGAGCCACCTTCTGAAAACGGA
ACAAGTATCTATGGGGCTGGTGGCTTTATGCCTTATGGCTTTACGGGAACGTTGGCTGGT
GCTGCAACTTGCTTTTATGCCTTTGTGGGATTTGACTGCATTGCAACAACTGGTGAAGAA
GTTCGGAATCCCCAGAAAGCTATTCCCATTGGAATTGTGACGTCTTTGCTTGTTTGCTTT
ATGGCCTATTTTGGGGTCTCTGCAGCTTTAACACTTATGATGCCGTACTACCTCCTCGAT
GAAAAAAGCCCCCTTCCTGTAGCGTTTGAATATGTGGGATGGGGTCCTGCCAAATATGTC
GTCGCAGCTGGTTCTCTCTGCGCCTTGTCAACAAGTCTTCTTGGATCCATTTTCCCAATG
CCTCGTGTAAACTATGCTATGGCGGAGGATGGGTTGCTTTTCAAATGTCTAGCTCAAATC
AATTCCAAAACGAAGACACCAATAATTGCTACTTTATCATCGGGTGCAGTGGCAGCTTTG
ATGGCCTTTCTGTTTGACCTGAAGGCGCTTGTGGACATGATGTCCATTGGCACACTCATG
GCCTACTCTCTGGTGGCAGCCTGTGTTCTCATCCTCAGGTACCAGCCTGGCTTATCTTAC
GACCAGCCCAAATGTTCTCCTGAGAAAGATGGTCTGGGATCGTCTCCCAGGGTAACCTCG
AAGAGTGAGTCCCAGGTCACCATGCTGCAGAGACAGGGCTTCAGCATGCGGACCCTCTTC
TGCCCCTCCCTTCTGCCAACACAGCAGTCAGCTTCTCTCGTGAGCTTTCTGGTAGGATTC
CTAGCTTTCCTCGTGTTGGGCCTGAGTGTCTTGACCACTTACGGAGTTCATGCCATCTAC
AGGCTGGAGGCCTGGAGCCTCGCTCTCCTCGCGCTGTTTCTTGTTCTCTTCGTTGCCATC
GTTCTCACCATCTGGAGGCAGCCCCAGAATCAACGAAAAGTAGCCTTCATGGTTCCATTC
TTACCATTTTTGCCGACGTTCACGATCTTGGTGAACATTTACTTGATGGTCCAGTTAAGT
GCAGACACTTGGGTCAGATTCAGCATTTGGATGGCAATTGGCTTCCTGATTTACTTTTCT
TATGGCATTAGACACAGCCTGGAGGGTCATCTGAGAGATGAAAACAATGAAGAAGATGCT
TATCCAGACAACGTTCATGCAGCAGCAGAAGAAAAATCTGCCATTCAAGCAAATGACCAT
CACCCAAGAAATCTCAGTTCACCTTTCATATTCCATGAAAAGACAAGTGAATTCTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
D29990

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:8

# Macromolecular_Interacting_Partner_3_Locus:
8p22-p21.3

# Macromolecular_Interacting_Partner_3_SNPs:
rs12680645; rs1134975; rs2517250; rs2299564; rs7838611; rs13259948; rs2285294; rs7842456; rs10093732; rs4921783; rs11987107; rs2285295; rs2517251; rs959426; rs2237817; rs3739416; rs956776; rs7827805; rs7842267; rs6586610; rs7014645; rs7822703; rs7842109; rs13275006; rs6980566; rs6998037; rs6983122; rs7842106; rs6991730; rs7823792; rs13281010; rs17124788; rs13282723; rs17124794; rs2705017; rs13398; rs2588241; rs13259978; rs2299566; rs11991148; rs13281204; rs14108; rs2299565; rs17504840; rs6999536; rs6998033; rs6982176; rs6998481; rs12156195; rs2301539; rs2588250; rs2720588; rs737039; rs2720590; rs3780121; rs2588252; rs2245491; rs2427721; rs2705062; rs10105500; rs2705018; rs2720559; rs6994712; rs2517254; rs2517257; rs2588248; rs2285293; rs2245492; rs2720558; rs10503597; rs2705061; rs17124818; rs2588247; rs2517252; rs2588243; rs2705019; rs6586609; rs17124823; rs17124830; rs10100359; rs17124809; rs2248010; rs17504917; rs11998060; rs2015840; rs10107764; rs17632706; rs2517253; rs17124843; rs7000018; rs2244738; rs2245183; rs17124835; rs6981597; rs2705065; rs9644582; rs2301540; rs2299567; rs11986520; rs2588246; rs17632632; rs11993109; rs7002951; rs17124783; rs17124778; rs2006214; rs17124777; rs6982625; rs885642; rs1134973; rs1804759; rs1981498; rs1134972; rs1134976; rs1134977; rs1134974; rs35978538; rs12156191; rs7826955; rs34780401; rs34068374; rs13271221; rs12155892; rs11427242; rs3959114; rs13275900; rs35741414; rs34091134; rs12156132; rs12155849; rs6980866; rs2248862; rs12156021; rs2237818; rs13280567; rs35506586; rs28615154; rs15239; rs28523587; rs34047096; rs3178072; rs35210464; rs10500; rs28520866; rs2705021; rs28573094; rs6991561; rs3173997; rs7827073; rs2427722; rs10645883; rs13253724; rs10112024; rs2588174; rs35923193; rs2588256; rs35409598; rs10658350; rs17124844; rs35737396; rs35838638; rs2588253; rs13279058; rs35596928; rs11373033; rs11203869; rs2285292; rs35252224; rs35949792; rs7014136; rs2440550; rs35268822; rs2517256; rs34282373; rs17124840; rs7017409; rs34882479; rs34699482; rs2588173; rs13279050; rs34982645; rs10104505; rs6996683; rs11203871; rs2588251; rs2588254; rs2427723; rs10100029; rs9792322; rs11373918; rs10658349; rs2720557; rs2588255; rs2705020; rs10654963; rs2440548; rs12155782; rs10658348; rs35052068; rs35618187; rs10658351; rs6996690; rs7828462; rs6989698; rs10106650; rs9644556; rs2466175; rs6150488; rs34146412; rs11203870; rs35800296; rs36061161; rs34817373; rs34505484; rs36099091; rs10087373; rs2588239; rs28617533; rs2720551; rs7462798; rs2720553; rs7003239; rs28733060; rs3178073; rs34272503; rs34626771; rs28616245; rs34194871; rs1003403; rs12156216; rs12679616; rs13263776; rs13268741; rs13272153; rs17124775; rs17632601; rs2517242; rs2517244; rs2517245; rs2517246; rs2517248; rs2517261; rs2517262; rs2517263; rs2517264; rs2517265; rs2517266; rs2517267; rs2588163; rs2588164; rs2588166; rs2588167; rs2588168; rs2588169; rs2588222; rs2588223; rs2588225; rs2588226; rs2588228; rs2588229; rs2588230; rs2588232; rs2588233; rs2588234; rs2588235; rs2705051; rs2705052; rs2705053; rs2705054; rs2705073; rs2705074; rs2705084; rs2720498; rs2720499; rs2720574; rs2720575; rs2720576; rs3214085; rs3780116; rs3780117; rs7016764; rs9792388

# Macromolecular_Interacting_Partner_3_General_References:
8954799

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8562

# Macromolecular_Interacting_Partner_4_Name:
System N amino acid transporter 1

# Macromolecular_Interacting_Partner_4_Synonyms:
SN1; N-system amino acid transporter 1; Solute carrier family 38 member 3

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC38A3

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>System N amino acid transporter 1
MEAPLQTEMVELVPNGKHSEGLLPVITPMAGNQRVEDPARSCMEGKSFLQKSPSKEPHFT
DFEGKTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLLTAVALLSSYSIHLLLKS
SGVVGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSYLYIIKSELPLVIQTFLNLEE
KTSDWYMNGNYLVILVSVTIILPLALMRQLGYLGYSSGFSLSCMVFFLIAVIYKKFHVPC
PLPPNFNNTTGNFSHVEIVKEKVQLQVEPEASAFCTPSYFTLNSQTAYTIPIMAFAFVCH
PEVLPIYTELKDPSKKKMQHISNLSIAVMYIMYFLAALFGYLTFYNGVESELLHTYSKVD
PFDVLILCVRVAVLTAVTLTVPIVLFPVRRAIQQMLFPNQEFSWLRHVLIAVGLLTCINL
LVIFAPNILGIFGVIGATSAPFLIFIFPAIFYFRIMPTEKEPARSTPKILALCFAMLGFL
LMTMSLSFIIIDWASGTSRHGGNH

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
504

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
55774

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.01

# Macromolecular_Interacting_Partner_4_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_4_Specific_Function:
Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_4_Signals:
1-111

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
83-103
106-126
144-164
187-207
213-233
324-344
366-386
408-428
431-451
471-491

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
S38A3_HUMAN (Q99624)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC38A3

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC38A3

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:18044

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cell membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
AF244548

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_4_Locus:
3p21.3

# Macromolecular_Interacting_Partner_4_SNPs:
rs2282749; rs4141407; rs2236939; rs2236940; rs2236941; rs2236942; rs739431; rs886075; rs2282750; rs35742391; rs739430; rs2006199; rs1858828; rs13084560; rs13320226; rs13084362; rs34370846; rs35137368; rs35768187; rs13084716; rs4688744; rs13084528; rs11709574; rs11293008; rs34840478; rs35219849; rs35195846; rs9847853; rs11385619; rs35374338; rs13084685; rs13084700; rs12635271; rs34366896; rs6792754; rs13064707; rs13084344; rs13084819; rs35306902; rs6779184; rs13084686; rs6791799; rs33915788; rs3831498; rs35926495; rs34382606; rs5848902; rs11442070; rs35686060; rs34974687; rs35851247; rs5848903; rs7611366; rs35756060; rs35667988; rs11919418; rs12485909; rs12631192; rs13064381; rs34877766; rs4525859; rs4688682; rs4688683; rs4688745; rs7617915; rs9883222

# Macromolecular_Interacting_Partner_4_General_References:
10823827; 11085536

# Macromolecular_Interacting_Partner_4_References:
Not Available

# Macromolecular_Interacting_Partner_5_ID:
8563

# Macromolecular_Interacting_Partner_5_Name:
Proline synthetase co-transcribed bacterial homolog protein

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
PROSC

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Proline synthetase cotranscribed bacterial homolog protein
MWRAGSMSAELGVGCALRAVNERVQQAVARRPRDLPAIQPRLVAVSKTKPADMVIEAYGH
GQRTFGENYVQELLEKASNPKILSLCPEIKWHFIGHLQKQNVNKLMAVPNLFMLETVDSV
KLADKVNSSWQRKGSPERLKVMVQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGL
MTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELSMGMSADFQHAVEVGSTNV
RIGSTIFGERDYSKKPTPDKCAADVKAPLEVAQEH

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
275

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
30344

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
7.57

# Macromolecular_Interacting_Partner_5_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF01168:Ala_racemase_N

# Macromolecular_Interacting_Partner_5_Signals:
Not Available

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
4126978

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
PROSC_HUMAN (O94903)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
PROSC

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
PROSC

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:9457

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AB018566

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:8

# Macromolecular_Interacting_Partner_5_Locus:
8p11.2

# Macromolecular_Interacting_Partner_5_SNPs:
rs35423325; rs7463174; rs6468438; rs6468439; rs13280389; rs10089505; rs7460808; rs11546424; rs3819034; rs34258343; rs28532175; rs35118325; rs34533624; rs13271273; rs34967654; rs13273392; rs6990030; rs34779193; rs34891571; rs3935246; rs11781108; rs7828362; rs35578595; rs13274171; rs1056017; rs13274161; rs34405971; rs34593340; rs10955032; rs10955033; rs11781156; rs11987971; rs11992961; rs13439126; rs6985987; rs7827663; rs915542

# Macromolecular_Interacting_Partner_5_General_References:
10496079; 11230166

# Macromolecular_Interacting_Partner_5_References:
Not Available

# Macromolecular_Interacting_Partner_6_ID:
8594

# Macromolecular_Interacting_Partner_6_Name:
SLC38A2 protein

# Macromolecular_Interacting_Partner_6_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_6_Gene_Name:
SLC38A2

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>SLC38A2 protein
MKQNLILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIG
AMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGY
TSGLSLLCMVFFLIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDS
CRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYL
LAALFGYLTFYEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTH
LLCASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIK
LVKKEPMKSVQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
406

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
45180

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
8.88

# Macromolecular_Interacting_Partner_6_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_6_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_6_Signals:
1-18

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
5-23; 48-69; 89-111; 115-137; 230-252; 272-294; 315-334; 339-361; 373-395

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
Q6IA88_HUMAN (Q6IA88)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SLC38A2

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SLC38A2

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:13448

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
CR457267

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_6_Locus:
12q

# Macromolecular_Interacting_Partner_6_SNPs:
rs10880961; rs7968283; rs956910; rs2897968; rs7968173; rs7961994; rs10880959; rs2307063; rs1873793; rs3742061; rs2307061; rs10880960; rs3782904; rs7965930; rs2307062; rs2279559; rs7974529; rs7960147; rs10785624; rs11183450; rs34139863; rs36065261; rs36022751; rs11340856; rs7966787; rs11313787; rs5797976; rs1046296; rs11183449; rs12307969; rs2307060; rs36019260; rs3837525; rs35534621; rs11183447; rs3832874; rs3830356; rs34489723; rs36066221; rs11298796; rs7295472; rs35732850; rs35944767; rs34099989; rs10880962; rs11183446; rs12368989; rs1492896; rs17096884; rs4768697; rs4768698; rs7135630; rs7967840; rs7975820; rs7979418

# Macromolecular_Interacting_Partner_6_General_References:
Not Available

# Macromolecular_Interacting_Partner_6_References:
Not Available

# Macromolecular_Interacting_Partner_7_ID:
8607

# Macromolecular_Interacting_Partner_7_Name:
SLC38A5 protein

# Macromolecular_Interacting_Partner_7_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Name:
SLC38A5

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>SLC38A5 protein
SIHLLLTCAGIAGIRAYEQLGQRAFGPAGKVVVATVICLHNVGAMSSYLFIIKSELPLVI
GTFLYMDPEGDWFLKGNLLIIIVSVLIILPLALMKHLGYLGYTSGLSLTCMLFFLVSVIY
KKFQLGCAIGHNETAMESEALVGLPSQGLNSSCEAQMFTVDSQMSYTVPIMAFAFVCHPE
VLPIYTELCRPSKRRMQAVANVSIGAMFCMYGLTATFGYLTFYSSVKAEMLHMYSQKDPL
ILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPGKAFSWPRHVAIALILLVLVNVLVICV
PTIRDIFGVIGSTSAPSLIFILPSIFYLRIVPSEVEPFLSWPKIQALCFGVLGVLFMAVS
LGFMFANWATGQSRMSGH

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
378

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
41426

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
8.47

# Macromolecular_Interacting_Partner_7_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_7_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_7_Signals:
1-16

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
31-52; 72-94; 98-120; 166-188; 198-220; 241-263; 278-300; 307-329; 344-366

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
40225675

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
Q6PIW9_HUMAN (Q6PIW9)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
SLC38A5

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
SLC38A5

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:18070

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1138 bp
CTCCATCCACCTCCTGCTGACCTGTGCTGGTATTGCAGGCATCCGAGCCTATGAGCAGCT
GGGACAGAGGGCATTCGGGCCTGCGGGGAAGGTAGTGGTGGCCACAGTCATCTGTCTGCA
CAATGTTGGGGCCATGTCCAGTTACCTGTTCATCATCAAATCTGAGCTCCCCCTGGTTAT
CGGCACCTTCCTGTACATGGACCCCGAGGGGGACTGGTTCTTGAAGGGAAACCTCCTCAT
CATCATCGTCAGTGTGTTAATCATCCTGCCCCTCGCCCTCATGAAACACTTGGGCTACCT
GGGGTACACCAGTGGTCTCTCTCTGACCTGCATGCTGTTTTTCCTTGTTTCGGTCATCTA
CAAGAAGTTCCAACTTGGCTGTGCTATAGGCCACAATGAAACAGCAATGGAGAGTGAAGC
TCTCGTGGGACTCCCCAGCCAAGGACTCAACAGCAGCTGTGAGGCCCAGATGTTCACAGT
TGACTCACAGATGTCCTACACAGTGCCCATTATGGCTTTTGCTTTTGTCTGCCACCCTGA
GGTGCTGCCCATCTATACGGAGCTCTGCCGGCCCTCCAAGCGCAGGATGCAGGCCGTGGC
CAACGTGTCCATTGGGGCCATGTTCTGCATGTATGGGCTCACAGCAACCTTTGGATACCT
CACCTTCTACAGCAGTGTGAAGGCGGAGATGCTGCACATGTACAGCCAGAAGGACCCGCT
CATCCTCTGTGTGCGCCTGGCCGTGCTGCTCGCGGTGACCCTCACTGTGCCAGTCGTGCT
GTTCCCTATCCGCCGGGCCCTGCAGCAGCTGCTTTTCCCAGGCAAGGCCTTCAGCTGGCC
ACGACATGTGGCCATAGCTCTGATCCTGCTTGTTTTGGTCAATGTCCTTGTCATCTGTGT
GCCAACCATCCGGGATATCTTTGGAGTTATCGGGTCCACCTCAGCCCCCAGCCTCATCTT
CATCCTCCCCAGCATCTTCTACCTCCGCATTGTACCCTCTGAGGTGGAGCCTTTCTTATC
CTGGCCCAAGATCCAGGCCCTGTGCTTTGGAGTCCTGGGAGTCCTCTTCATGGCCGTCAG
TCTAGGCTTTATGTTTGCCAACTGGGCCACAGGCCAGAGCCGCATGTCTGGACACTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
BC027721

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_7_Locus:
Xp11.23

# Macromolecular_Interacting_Partner_7_SNPs:
rs17281188; rs2293953; rs2293952; rs909322; rs12014551; rs5905691; rs2272657; rs5906670; rs17148207; rs34099520; rs12851533; rs5906672; rs12851546; rs12838813; rs6608806; rs34145896; rs28469063; rs10671203; rs4988523; rs35633286; rs35982043; rs4988522; rs2293951; rs5902424; rs5906671; rs5902425; rs35863886; rs10577901; rs4480243; rs34884148; rs10578218; rs5953238; rs34820839; rs3840968; rs10533882; rs1040344; rs12840106; rs2268954; rs2977590; rs2977591; rs4824714; rs5952506; rs7876401

# Macromolecular_Interacting_Partner_7_General_References:
12477932

# Macromolecular_Interacting_Partner_7_References:
Not Available

# Macromolecular_Interacting_Partner_8_ID:
8627

# Macromolecular_Interacting_Partner_8_Name:
4F2 cell-surface antigen heavy chain

# Macromolecular_Interacting_Partner_8_Synonyms:
4F2hc; Lymphocyte activation antigen 4F2 large subunit; 4F2 heavy chain antigen; CD98 antigen

# Macromolecular_Interacting_Partner_8_Gene_Name:
SLC3A2

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>4F2 cellsurface antigen heavy chain
MSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKF
TGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHT
GALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQID
PNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAG
VDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLT
SSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLP
GTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLS
LFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQAS
DLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYAA

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
529

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
57945

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
4.99

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  amylase activity
Function:  alpha-amylase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_8_Specific_Function:
Involved in sodium-independent, high-affinity transport of large neutral amino acids. Required for normal and neoplastic cell growth

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00128:Alpha-amylase

# Macromolecular_Interacting_Partner_8_Signals:
1-98

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
82-104

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
182865

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
4F2_HUMAN (P08195)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
SLC3A2

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
SLC3A2

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:11026

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Membrane; single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1590 bp
ATGAGCCAGGACACCGAGGTGGATATGAAGGAGGTGGAGCTGAATGAGTTAGAGCCCGAG
AAGCAGCCGATGAACGCGGCGTCTGGGGCGGCCATGTCCCTGGCGGGAGCCGAGAAGAAT
GGTCTGGTGAAGATCAAGGTGGCGGAAGACGAGGCGGAGGCGGCAGCCGCGGCTAAGTTC
ACGGGCCTGTCCAAGGAGGAGCTGCTGAAGGTGGCAGGCAGCCCCGGCTGGGTACGCACC
CGCTGGGCACTGCTGCTGCTCTTCTGGCTCGGCTGGCTCGGCATGCTTGCTGGTGCCGTG
GTCATAATCGTGCGAGCGCCGCGTTGTCGCGAGCTACCGGCGCAGAAGTGGTGGCACACG
GGCGCCCTCTACCGCATCGGCGACCTTCAGGCCTTCCAGGGCCACGGCGCGGGCAACCTG
GCGGGTCTGAAGGGGCGTCTCGATTACCTGAGCTCTCTGAAGGTGAAGGGCCTTGTGCTG
GGTCCAATTCACAAGAACCAGAAGGATGATGTCGCTCAGACTGACTTGCTGCAGATCGAC
CCCAATTTTGGCTCCAAGGAAGATTTTGACAGTCTCTTGCAATCGGCTAAAAAAAAGAGC
ATCCGTGTCATTCTGGACCTTACTCCCAACTACCGGGGTGAGAACTCGTGGTTCTCCACT
CAGGTTGACACTGTGGCCACCAAGGTGAAGGATGCTCTGGAGTTTTGGCTGCAAGCTGGC
GTGGATGGGTTCCAGGTTCGGGACATAGAGAATCTGAAGGATGCATCCTCATTCTTGGCT
GAGTGGCAAAATATCACCAAGGGCTTCAGTGAAGACAGGCTCTTGATTGCGGGGACTAAC
TCCTCCGACCTTCAGCAGATCCTGAGCCTACTCGAATCCAACAAAGACTTGCTGTTGACT
AGCTCATACCTGTCTGATTCTGGTTCTACTGGGGAGCATACAAAATCCCTAGTCACACAG
TATTTGAATGCCACTGGCAATCGCTGGTGCAGCTGGAGTTTGTCTCAGGCAAGGCTCCTG
ACTTCCTTCTTGCCGGCTCAACTTCTCCGACTCTACCAGCTGATGCTCTTCACCCTGCCA
GGGACCCCTGTTTTCAGCTACGGGGATGAGATTGGCCTGGATGCAGCTGCCCTTCCTGGA
CAGCCTATGGAGGCTCCAGTCATGCTGTGGGATGAGTCCAGCTTCCCTGACATCCCAGGG
GCTGTAAGTGCCAACATGACTGTGAAGGGCCAGAGTGAAGACCCTGGCTCCCTCCTTTCC
TTGTTCCGGCGGCTGAGTGACCAGCGGAGTAAGGAGCGCTCCCTACTGCATGGGGACTTC
CACGCGTTCTCCGCTGGGCCTGGACTCTTCTCCTATATCCGCCACTGGGACCAGAATGAG
CGTTTTCTGGTAGTGCTTAACTTTGGGGATGTGGGCCTCTCGGCTGGACTGCAGGCCTCC
GACCTGCCTGCCAGCGCCAGCCTCCCAGCCAAGGCTGACCTCCTGCTCAGCACCCAGCCA
GGCCGTGAGGAGGGCTCCCCTCTTGAGCTGGAACGCCTGAAACTGGAGCCTCACGAAGGG
CTGCTGCTCCGCTTCCCCTACGCGGCCTGA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
J02939

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_8_Locus:
11q13

# Macromolecular_Interacting_Partner_8_SNPs:
rs4726; rs6932; rs489381; rs10897300; rs10897301; rs10792362; rs3809075; rs12221878; rs481235; rs12577251; rs4567465; rs12794763; rs7104190; rs507101; rs7106901; rs12098955; rs561385; rs519473; rs12804553; rs12274689; rs7935096; rs2070870; rs2920155; rs2282477; rs1140538; rs7944051; rs3015957; rs11548759; rs1051342; rs11548756; rs1051289; rs1051290; rs1802910; rs1051237; rs1802911; rs11548760; rs1051285; rs12272749; rs35228448; rs540791; rs549706; rs11231260; rs543622; rs541444; rs34047097; rs35246991; rs1815840; rs3840765; rs11231257; rs544453; rs35881347; rs35320203; rs2957168; rs7130029; rs519425; rs541388; rs34176851; rs535854; rs35091612; rs7106895; rs2096559; rs473815; rs11318751; rs5792273; rs12797676; rs499294; rs34225665; rs3809074; rs2957166; rs7115838; rs12803557; rs521939; rs1938675; rs563394; rs1300138; rs12225962; rs2105515; rs36034735; rs486306; rs12788771; rs1212628; rs1286159; rs5792274; rs12794229; rs7117639; rs495776; rs11231259; rs12366036; rs509327; rs35657900; rs11231261; rs496788; rs35988334; rs12788770; rs34335071; rs1298673; rs766316; rs34722625; rs560603; rs11824602; rs565303; rs34494671; rs35455481; rs7101685; rs1286160; rs510307; rs12270563; rs11231254; rs11231262; rs11318752; rs549635; rs12270604; rs2957167; rs11317361; rs7126772; rs34436839; rs11341257; rs577134; rs11558674; rs1059292; rs11231249; rs11231250; rs12270342; rs12295052; rs1785940; rs2071036; rs2269353; rs2507820; rs2509678; rs2510083; rs3737388; rs3737389; rs4034; rs480730; rs493851; rs498751; rs524891; rs547248; rs560006

# Macromolecular_Interacting_Partner_8_General_References:
3476959; 3036867; 3480538; 3265470; 12754519; 11840567; 12270127

# Macromolecular_Interacting_Partner_8_References:
Not Available

# Macromolecular_Interacting_Partner_9_ID:
8650

# Macromolecular_Interacting_Partner_9_Name:
Neutral amino acid transporter A

# Macromolecular_Interacting_Partner_9_Synonyms:
SATT; Solute carrier family 1 member 4; Alanine/serine/cysteine/ threonine transporter; ASCT1

# Macromolecular_Interacting_Partner_9_Gene_Name:
SLC1A4

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Neutral amino acid transporter 
AMEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLG
AALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVA
YFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLF
PSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKK
LGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIF
ASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEEN
NGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVG
AAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQ
KATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
532

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
55724

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
6.18

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
 Function:  transporter activity
Function:  organic acid transporter activity
Function:  carboxylic acid transporter activity
Function:  dicarboxylic acid transporter activity
Function:  sodium:dicarboxylate symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  organic acid transport
Process:  carboxylic acid transport
Process:  dicarboxylic acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_9_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_9_Specific_Function:
Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00375:SDF

# Macromolecular_Interacting_Partner_9_Signals:
1-104

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
42-62
88-108
119-139
217-237
257-277
298-318
328-348
373-393
418-438

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
348012

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
SATT_HUMAN (P43007)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
SLC1A4

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
SLC1A4

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:10942

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Membrane; multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>1599 bp
ATGGAGAAGAGCAACGAGACCAACGGCTACCTTGACAGCGCTCAGGCGGGGCCTGCGGCC
GGGCCCGGAGCTCCGGGGACCGCGGCGGGACGCGCACGGCGTTGCGCGCGCTTCCTGCGG
CGCCAAGCGCTGGTGCTGCTCACCGTGTCCGGGGTGCTGGCGGGCGCGGGCCTGGGCGCG
GCGTTGCGCGGGCTCAGCCTGAGCCGCACGCAGGTCACCTACCTGGCCTTCCCCGGCGAG
ATGCTGCTCCGCATGCTGCGCATGATCATCCTGCCGCTGGTGGTCTGCAGCCTGGTGTCG
GGCGCCGCCTCGCTCGATGCCAGCTGCCTCGGGCGTCTGGGCGGCATCCGTGTCGCCTAC
TTTGGCCTCACCACACTGAGTGCCTCGGCGCTCGCCGTGGCCTTGGCGTTCATCATCAAG
CCAGGATCCGGTGCGCAGACCCTTCAGTCCAGCGACCTGGGGCTGGAGGACTCGGGGCCT
CCTCCTGTCCCCAAAGAGACGGTGGACTCTTTCCTCGACCTGGCCAGAAACCTGTTTCCC
TCCAATCTTGTGGTTGCAGCTTTCCGTACGTATGCAACCGATTATAAAGTCGTGACCCAG
AACAGCAGCTCTGGAAATGTAACCCATGAAAAGATCCCCATAGGCACTGAGATAGAAGGG
ATGAACATTTTAGGATTGGTCCTGTTTGCTCTGGTGTTAGGAGTGGCCTTAAAGAAACTA
GGCTCCGAAGGAGAAGACCTCATCCGTTTCTTCAATTCCCTCAACGAGGCGACGATGGTG
CTGGTGTCCTGGATTATGTGGTACGTACCTGTGGGCATCATGTTCCTTGTTGGAAGCAAG
ATCGTGGAAATGAAAGACATCATCGTGCTGGTGACCAGCCTGGGGAAATACATCTTCGCA
TCTATATTGGGCCATGTTATTCATGGAGGAATTGTTCTGCCACTTATTTATTTTGTTTTC
ACACGAAAAAACCCATTCAGATTCCTCCTGGGCCTCCTCGCCCCATTTGCGACAGCATTT
GCTACCTGCTCCAGCTCAGCGACCCTTCCCTCTATGATGAAGTGCATTGAAGAGAACAAT
GGTGTGGACAAGAGGATCAGCAGGTTTATTCTCCCCATCGGGGCCACCGTGAACATGGAC
GGAGCAGCCATCTTCCAGTGTGTGGCCGCGGTGTTCATTGCGCAACTCAACAACATAGAG
CTCAACGCAGGACAGATTTTCACCATTCTAGTGACTGCCACAGCGTCCAGTGTTGGAGCA
GCAGGCGTGCCAGCTGGAGGGGTCCTCACCATTGCCATTATCCTGGAGGCCATTGGGCTG
CCTACTCATGACCTGCCTCTGATCCTGGCTGTGGACTGGATTGTGGACCGGACCACCACG
GTGGTGAATGTGGAAGGGGATGCCCTGGGTGCAGGCATTCTCCACCACCTGAATCAGAAG
GCAACAAAGAAAGGCGAGCAGGAACTTGCTGAGGTGAAAGTGGAAGCCATCCCCAACTGC
AAGTCTGAGGAGGAGACATCGCCCCTGGTGACACACCAGAACCCCGCTGGCCCCGTGGCC
AGTGCCCCAGAACTGGAATCCAAGGAGTCGGTTCTGTGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
L14595

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_9_Locus:
2p15-p13

# Macromolecular_Interacting_Partner_9_SNPs:
rs759458; rs7563131; rs7559202; rs7589132; rs7850; rs1058922; rs1058926; rs3796052; rs7563257; rs10197339; rs7574431; rs2075209; rs3732062; rs6546119; rs6728107; rs6546120; rs1060315; rs2422358; rs11891502; rs12617488; rs3770705; rs10194230; rs2268483; rs1541580; rs11891647; rs7570684; rs3819816; rs7588457; rs7583682; rs7586345; rs7559797; rs11904597; rs17029749; rs11886554; rs2268481; rs11687321; rs11890755; rs2300546; rs7580228; rs2007061; rs1861443; rs7601530; rs7601029; rs7574973; rs11689731; rs17029736; rs12615879; rs7601562; rs7601142; rs7566124; rs17029737; rs11900188; rs11675218; rs12615528; rs7605525; rs7605452; rs17029771; rs7425340; rs1064512; rs34259099; rs6756968; rs34416635; rs13398698; rs35024658; rs12620864; rs7609068; rs12620890; rs13416211; rs7608915; rs3839063; rs34497145; rs7563137; rs11283317; rs35937278; rs35342526; rs35002509; rs10173484; rs2160387; rs5831732; rs2300548; rs10190648; rs34956531; rs34093121; rs2422359; rs17624279; rs10659734; rs3216589; rs34617398; rs34461710; rs34352138; rs10176896; rs7569409; rs11343144; rs36110974; rs34954546; rs11277470; rs2300547; rs11352632; rs6706035; rs10659733; rs35815508; rs17029731; rs2268479; rs34557334; rs2268482; rs13032158; rs34790840; rs34330989; rs11343057; rs35311819; rs34807901; rs11352633; rs10572273; rs34203436; rs35022766; rs7585341; rs1056703; rs9808015; rs13010290; rs6712347; rs10182988; rs3770707; rs7559886; rs6750052; rs7592468; rs11449616; rs34467179; rs34598433; rs7592015; rs34799701; rs35470885; rs35894508; rs11888075; rs2268480; rs13392255; rs3770706; rs34821720; rs2268478; rs11292885; rs2110950; rs11274301; rs7569840; rs11542203; rs1008617; rs11390852; rs12998384; rs7604992; rs10170033; rs10193537; rs7608786; rs35490784; rs10209552; rs10211524; rs12464724; rs17669826; rs2422435; rs2540966; rs2540967; rs2540969; rs2540970; rs2723076; rs35528068; rs6546118; rs7574847; rs9677813

# Macromolecular_Interacting_Partner_9_General_References:
8101838; 8340364; 7896285

# Macromolecular_Interacting_Partner_9_References:
Not Available

# Macromolecular_Interacting_Partner_10_ID:
8656

# Macromolecular_Interacting_Partner_10_Name:
Cationic amino acid transporter 3

# Macromolecular_Interacting_Partner_10_Synonyms:
CAT-3; Solute carrier family 7 member 3; Cationic amino acid transporter y+

# Macromolecular_Interacting_Partner_10_Gene_Name:
SLC7A3

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Cationic amino acid transporter 3
MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD
KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS
YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA
LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL
GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF
AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI
YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL
VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC
SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK
VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR
KSRAKTVDLDPGTLYVHSV

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
619

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
67170

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
6.11

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
 Function:  amino acid permease activity
Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
 Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_10_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_10_Specific_Function:
Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_10_Signals:
1-305

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
37-57
62-82
108-128
163-183
192-212
234-254
286-306
336-356
383-403
407-427
476-496
507-527
541-561
570-590

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
17224957

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
CTR3_HUMAN (Q8WY07)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
SLC7A3

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
SLC7A3

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:11061

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Cell membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>1860 bp
ATGCCGTGGCAAGCATTTCGCAGATTTGGTCAAAAGCTGGTACGCAGACGTACACTGGAG
TCAGGCATGGCTGAGACTCGCCTTGCCAGATGCCTAAGCACCCTGGATTTAGTGGCCCTG
GGTGTGGGCAGCACATTGGGTGCAGGCGTGTATGTCCTAGCTGGCGAGGTGGCCAAAGAT
AAAGCAGGGCCATCCATTGTGATCTGCTTTTTGGTGGCTGCCCTGTCTTCTGTGTTGGCT
GGGCTGTGCTATGCGGAGTTTGGTGCCCGGGTTCCCCGTTCTGGTTCGGCATATCTCTAC
AGCTATGTCACTGTGGGTGAACTCTGGGCCTTCACCACTGGCTGGAACCTCATCCTCTCC
TATGTCATTGGTACAGCCAGTGTGGCCCGGGCCTGGAGCTCTGCTTTTGACAACCTGATT
GGGAACCACATCTCTAAGACTCTGCAGGGGTCCATTGCACTGCACGTGCCCCATGTCCTT
GCAGAATATCCAGATTTCTTTGCTTTGGGCCTCGTGTTGCTGCTCACTGGATTGTTGGCT
CTCGGGGCTAGTGAGTCGGCCCTGGTTACCAAAGTGTTCACAGGCGTGAACCTTTTGGTT
CTTGGGTTCGTCATGATCTCTGGCTTCGTTAAGGGGGACGTGCACAACTGGAAGCTCACA
GAAGAGGACTACGAATTGGCCATGGCTGAACTCAATGACACCTATAGCTTGGGTCCTCTG
GGCTCTGGAGGATTTGTGCCTTTCGGCTTCGAGGGAATTCTCCGTGGAGCAGCGACCTGT
TTCTATGCATTTGTTGGTTTCGACTGTATTGCTACCACTGGAGAAGAAGCCCAGAATCCC
CAGCGTTCCATCCCGATGGGCATTGTGATCTCACTGTCTGTCTGCTTTTTGGCGTATTTT
GCTGTCTCTTCTGCACTCACCCTGATGATGCCTTACTACCAGCTTCAGCCTGAGAGCCCT
TTGCCTGAGGCATTTCTCTACATTGGATGGGCTCCTGCCCGCTATGTTGTGGCTGTTGGC
TCCCTCTGTGCTCTTTCTACCAGCCTCCTGGGCTCCATGTTCCCCATGCCTCGGGTGATC
TACGCGATGGCAGAGGATGGCCTCCTGTTCCGTGTACTTGCTCGGATCCACACCGGCACA
CGCACCCCAATCATAGCCACCGTGGTCTCTGGCATTATTGCAGCATTCATGGCATTCCTC
TTCAAACTCACTGATCTTGTGGACCTCATGTCAATTGGGACCCTGCTTGCTTACTCCCTG
GTGTCGATTTGTGTTCTCATCCTCAGGTATCAACCTGATCAGGAGACAAAGACTGGGGAA
GAAGTGGAGTTGCAGGAGGAGGCAATAACTACTGAATCAGAGAAGTTGACCCTATGGGGA
CTATTTTTCCCACTCAACTCCATCCCCACTCCACTCTCTGGCCAAATTGTCTATGTTTGT
TCCTCATTGCTTGCTGTCCTGCTGACTGCTCTTTGCCTGGTGCTGGCCCAGTGGTCAGTT
CCATTGCTTTCTGGAGACCTGCTGTGGACTGCAGTGGTTGTGCTGCTCCTGCTGCTCATT
ATTGGGATCATTGTGGTCATCTGGAGACAGCCACAGAGTTCCACTCCCCTTCACTTTAAG
GTGCCTGCTTTGCCTCTCCTCCCACTAATGAGCATCTTTGTGAATATTTACCTTATGATG
CAGATGACAGCTGGTACCTGGGCCCGATTTGGGGTCTGGATGCTGATTGGCTTTGCTATC
TACTTCGGCTATGGGATCCAGCACAGCCTGGAAGAGATTAAGAGTAACCAACCCTCACGC
AAGTCTAGAGCCAAAACTGTAGACCTTGATCCCGGCACTCTCTATGTCCACTCAGTTTGA


# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
AF320612

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_10_Locus:
Xq13.1

# Macromolecular_Interacting_Partner_10_SNPs:
rs6525447; rs5936604; rs7885836; rs6625713; rs7890581; rs7886610; rs7891155; rs4524964; rs17853219; rs4360450; rs5902678; rs41310635; rs34548199; rs12556893; rs4844277; rs4844278; rs4844279; rs4844280; rs5936607; rs5936609; rs5936610; rs5937024; rs5937025; rs5981030; rs6624517; rs6625721; rs7881738

# Macromolecular_Interacting_Partner_10_General_References:
11591158

# Macromolecular_Interacting_Partner_10_References:
Not Available

# Macromolecular_Interacting_Partner_11_ID:
8673

# Macromolecular_Interacting_Partner_11_Name:
Sodium-coupled neutral amino acid transporter 4

# Macromolecular_Interacting_Partner_11_Synonyms:
Na(+-coupled neutral amino acid transporter 4; Amino acid transporter A3; System A amino acid transporter 3; System N amino acid transporter 3; Solute carrier family 38 member 4

# Macromolecular_Interacting_Partner_11_Gene_Name:
SLC38A4

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Sodiumcoupled neutral amino acid transporter 4
MDPMELRNVNIEPDDESSSGESAPDSYIGIGNSEKAAMSSQFANEDTESQKFLTNGFLGK
KKLADYADEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSL
YSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEV
IRAFMGLEENTGEWYLNGNYLIIFVSVGIILPLSLLKNLGYLGYTSGFSLTCMVFFVSVV
IYKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLPNNSESSDVNFMMDYTHRNPAGLDEN
QAKGSLHDSGVEYEAHSDDKCEPKYFVFNSRTAYAIPILVFAFVCHPEVLPIYSELKDRS
RRKMQTVSNISITGMLVMYLLAALFGYLTFYGEVEDELLHAYSKVYTLDIPLLMVRLAVL
VAVTLTVPIVLFPIRTSVITLLFPKRPFSWIRHFLIAAVLIALNNVLVILVPTIKYIFGF
IGASSATMLIFILPAVFYLKLVKKETFRSPQKVGALIFLVVGIFFMIGSMALIIIDWIYD
PPNSKHH

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
547

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
60765

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
6.45

# Macromolecular_Interacting_Partner_11_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_11_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_11_Specific_Function:
Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_11_Signals:
1-531

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
81-101
105-125
152-172
196-216
221-241
333-353
370-390
412-432
454-474
477-497
515-535

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
13876616

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
S38A4_HUMAN (Q969I6)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
SLC38A4

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
SLC38A4

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:14679

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Cell membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>1644 bp
ATGGATCCCATGGAACTGAGAAATGTCAACATCGAACCAGATGATGAGAGCAGCAGTGGA
GAAAGTGCTCCAGATAGCTACATCGGGATAGGAAATTCAGAAAAGGCAGCAATGAGCAGT
CAATTTGCTAATGAAGACACTGAAAGTCAGAAATTCCTGACAAATGGATTTTTGGGGAAA
AAGAAGCTGGCAGATTATGCTGATGAACACCATCCCGGAACCACTTCCTTTGGAATGTCT
TCATTTAACCTGAGTAATGCCATCATGGGCAGTGGGATCCTGGGCTTGTCCTATGCCATG
GCCAACACAGGGATCATACTTTTTATAATCATGCTGCTTGCTGTGGCAATATTATCACTG
TATTCAGTTCACCTTTTATTAAAAACAGCCAAGGAAGGAGGGTCTTTGATTTATGAAAAA
TTAGGAGAAAAGGCATTTGGATGGCCGGGAAAAATTGGAGCTTTTGTTTCCATTACAATG
CAGAACATTGGAGCAATGTCAAGCTACCTCTTTATCATTAAATATGAACTACCTGAAGTA
ATCAGAGCATTCATGGGACTTGAAGAAAATACTGGAGAATGGTACCTCAATGGCAACTAC
CTCATCATATTTGTGTCTGTTGGAATTATTCTTCCACTTTCGCTCCTTAAAAATTTAGGT
TATCTTGGCTATACCAGTGGATTTTCTCTTACCTGCATGGTGTTTTTTGTTAGTGTGGTG
ATTTACAAGAAATTCCAAATACCCTGCCCTCTACCTGTTTTGGATCACAGTGTTGGAAAT
CTGTCATTCAACAACACGCTTCCAATGCATGTGGTAATGTTACCCAACAACTCTGAGAGT
TCTGATGTGAACTTCATGATGGATTACACCCACCGCAATCCTGCAGGGCTGGATGAGAAC
CAGGCCAAGGGCTCTCTTCATGACAGTGGAGTAGAATATGAAGCTCATAGTGATGACAAG
TGTGAACCCAAATACTTTGTATTCAACTCCCGGACGGCCTATGCAATTCCTATCCTAGTA
TTTGCTTTTGTATGCCACCCTGAGGTCCTTCCCATCTACAGTGAACTTAAAGATCGGTCC
CGGAGAAAAATGCAAACGGTGTCAAATATTTCCATCACGGGGATGCTTGTCATGTACCTG
CTTGCCGCCCTCTTTGGTTACCTAACCTTCTATGGAGAAGTTGAAGATGAATTACTTCAT
GCCTACAGCAAAGTGTATACATTAGACATCCCTCTTCTCATGGTTCGCCTGGCAGTCCTT
GTGGCAGTAACACTAACTGTGCCCATTGTCCTCTTCCCAATTCGTACATCAGTGATCACA
CTGTTATTTCCCAAACGACCCTTCAGCTGGATACGACATTTCCTGATTGCAGCTGTGCTT
ATTGCACTTAATAATGTTCTGGTCATCCTTGTGCCAACTATAAAATACATCTTCGGATTC
ATAGGGGCTTCTTCTGCCACTATGCTGATTTTTATTCTTCCAGCAGTTTTTTATCTTAAA
CTTGTCAAGAAAGAAACTTTTAGGTCACCCCAAAAGGTCGGGGCTTTAATTTTCCTTGTG
GTTGGAATATTCTTCATGATTGGAAGCATGGCACTCATTATAATTGACTGGATTTATGAT
CCTCCAAATTCCAAGCATCACTAA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
AF305814

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_11_Locus:
12q13

# Macromolecular_Interacting_Partner_11_SNPs:
rs2429467; rs11183610; rs180414; rs2465604; rs2429472; rs2250010; rs2191162; rs2715788; rs2465608; rs2430921; rs4627160; rs11183605; rs180438; rs2897981; rs10881001; rs2079787; rs7974413; rs11183618; rs2429470; rs4482114; rs11183617; rs7963399; rs11183616; rs7967842; rs4587804; rs7132006; rs10161209; rs2109125; rs11183619; rs2465605; rs3862137; rs4569081; rs11183620; rs12321267; rs12582305; rs12424453; rs7968752; rs7954772; rs2429473; rs7963807; rs2465586; rs17097332; rs4447249; rs7138295; rs7959916; rs7953215; rs7973308; rs12304394; rs4491335; rs180437; rs12301396; rs10748455; rs2429471; rs12300935; rs4554975; rs12318696; rs10437941; rs7963364; rs10881002; rs7971412; rs7974393; rs12227634; rs17666239; rs12301345; rs11183621; rs17097341; rs10881003; rs180430; rs180431; rs2715779; rs2465585; rs180416; rs2465584; rs180421; rs1860372; rs180408; rs180433; rs180410; rs180409; rs180420; rs180417; rs7297226; rs4768758; rs2287471; rs180427; rs180419; rs2429474; rs4768759; rs2430922; rs2465583; rs6582676; rs180407; rs11183608; rs2465582; rs180434; rs180405; rs11183609; rs180426; rs180435; rs180412; rs2465644; rs12307687; rs180424; rs180429; rs180415; rs17097246; rs2075335; rs12305532; rs180428; rs12316767; rs2287472; rs12581848; rs12307218; rs4768757; rs180425; rs12317419; rs12306007; rs3794308; rs12301214; rs2302855; rs180423; rs180403; rs17097220; rs12313427; rs17602430; rs1860371; rs12826359; rs180422; rs2429465; rs2287473; rs17097286; rs11609184; rs2429466; rs180436; rs180404; rs1468970; rs1468972; rs1468971; rs2465614; rs4340151; rs2430920; rs2465613; rs12315893; rs7489259; rs7976413; rs7962993; rs7965688; rs7976286; rs4262792; rs12309262; rs35448881; rs5797999; rs12426237; rs34557682; rs10523982; rs12824626; rs2543339; rs4537845; rs34666594; rs2429469; rs10161451; rs34886536; rs5798000; rs4575359; rs11558891; rs9804926; rs10693721; rs4388977; rs2430923; rs2429468; rs34878223; rs3764027; rs2465606; rs2465588; rs35064296; rs17097355; rs34251832; rs12308177; rs1072246; rs2465587; rs4335624; rs5798001; rs2907513; rs12819255; rs4768756; rs2532606; rs11370884; rs34540549; rs12298652; rs34594658; rs4623983; rs35779004; rs35709312; rs2429464; rs10691485; rs12832145; rs35826321; rs180413; rs2216433; rs35066357; rs12319423; rs2465616; rs10691484; rs11610757; rs11315253; rs34637197; rs17097192; rs35050099; rs7313706; rs549755; rs36053062; rs11335369; rs3217194; rs11183614; rs12318924; rs4631970; rs34909119; rs12316757; rs180411; rs180432; rs10673975; rs34246069; rs35085914; rs180406; rs34654635; rs34189139; rs11335992; rs4439596; rs416435; rs35774013; rs5797998; rs3958775; rs35668113; rs446993; rs180418; rs34764764; rs34209899; rs11338774; rs10785645; rs11183625; rs11609070; rs11615573; rs12307895; rs12311057; rs12317975; rs12318756; rs12318994; rs12812119; rs17097368; rs17684703; rs2193649; rs2216432; rs2408623; rs2430917; rs2430919; rs2465595; rs2715775; rs2715783; rs4374015; rs4495962; rs4497488; rs4511364; rs4533116; rs4994910; rs7953233; rs7955552; rs7964210; rs7978689; rs7978822; rs7978926

# Macromolecular_Interacting_Partner_11_General_References:
11342143; 11414754

# Macromolecular_Interacting_Partner_11_References:
Not Available

# Macromolecular_Interacting_Partner_12_ID:
8787

# Macromolecular_Interacting_Partner_12_Name:
High-affinity cationic amino acid transporter 1

# Macromolecular_Interacting_Partner_12_Synonyms:
CAT-1; CAT1; System Y+ basic amino acid transporter; Ecotropic retroviral leukemia receptor homolog; ERR; Ecotropic retrovirus receptor homolog

# Macromolecular_Interacting_Partner_12_Gene_Name:
SLC7A1

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Highaffinity cationic amino acid transporter 1
MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE
NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS
YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT
LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG
KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA
YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR
VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY
SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI
LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA
VVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIY
FGYGLWHSEEASLDADQARTPDGNLDQCK

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
629

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
67639

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
5.06

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
 Function:  amino acid permease activity
Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
 Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_12_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_12_Specific_Function:
High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_12_Signals:
1-540

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
36-57
62-82
103-123
163-183
192-212
247-267
288-307
338-358
385-405
409-429
493-513
527-551
560-580
585-605

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
36161

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
CTR1_HUMAN (P30825)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
SLC7A1

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
SLC7A1

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:11057

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>1890 bp
ATGGGGTGCAAAGTCCTGCTCAACATTGGGCAGCAGATGCTGCGGCGGAAGGTGGTGGAC
TGTAGCCGGGAGGAGACGCGGCTGTCTCGCTGCCTGAACACTTTTGATCTGGTGGCCCTC
GGGGTGGGCAGCACACTGGGTGCTGGTGTCTACGTCCTGGCTGGAGCTGTGGCCCGTGAG
AATGCAGGCCCTGCCATTGTCATCTCCTTCCTGATCGCTGCGCTGGCCTCAGTGCTGGCT
GGCCTGTGCTATGGCGAGTTTGGTGCTCGGGTCCCCAAGACGGGCTCAGCTTACCTCTAC
AGCTATGTCACCGTTGGAGAGCTCTGGGCCTTCATCACCGGCTGGAACTTAATCCTCTCC
TACATCATCGGTACTTCAAGCGTAGCGAGGGCCTGGAGCGCCACCTTCGACGAGCTGATA
GGCAGACCCATCGGGGAGTTCTCACGGACACACATGACTCTGAACGCCCCCGGCGTGCTG
GCTGAAAACCCCGACATATTCGCAGTGATCATAATTCTCATCTTGACAGGACTTTTAACT
CTTGGTGTGAAAGAGTCGGCCATGGTCAACAAAATATTCACTTGTATTAACGTCCTGGTC
CTGGGCTTCATAATGGTGTCAGGATTTGTGAAAGGATCGGTTAAAAACTGGCAGCTCACG
GAGGAGGATTTTGGGAACACATCAGGCCGTCTCTGTTTGAACAATGACACAAAAGAAGGG
AAGCCCGGTGTTGGTGGATTCATGCCCTTCGGGTTCTCTGGTGTCCTGTCGGGGGCAGCG
ACTTGCTTCTATGCCTTCGTGGGCTTTGACTGCATCGCCACCACAGGTGAAGAGGTGAAG
AACCCACAGAAGGCCATCCCCGTGGGGATCGTGGCGTCCCTCTTGATCTGCTTCATCGCC
TACTTTGGGGTGTCGGCTGCCCTCACGCTCATGATGCCCTACTTCTGCCTGGACAATAAC
AGCCCCCTGCCCGACGCCTTTAAGCACGTGGGCTGGGAAGGTGCCAAGTACGCAGTGGCC
GTGGGCTCCCTCTGCGCTCTTTCCGCCAGTCTTCTAGGTTCCATGTTTCCCATGCCTCGG
GTTATCTATGCCATGGCTGAGGATGGACTGCTATTTAAATTCTTAGCCAACGTCAATGAT
AGGACCAAAACACCAATAATCGCCACATTAGCCTCGGGTGCCGTTGCTGCTGTGATGGCC
TTCCTCTTTGACCTGAAGGACTTGGTGGACCTCATGTCCATTGGCACTCTCCTGGCTTAC
TCGTTGGTGGCTGCCTGTGTGTTGGTCTTACGGTACCAGCCAGAGCAGCCTAACCTGGTA
TACCAGATGGCCAGTACTTCCGACGAGTTAGATCCAGCAGACCAAAATGAATTGGCAAGC
ACCAATGATTCCCAGCTGGGGTTTTTACCAGAGGCAGAGATGTTCTCTTTGAAAACCATA
CTCTCACCCAAAAACATGGAGCCTTCCAAAATCTCTGGGCTAATTGTGAACATTTCAACC
AGCCTTATAGCTGTTCTCATCATCACCTTCTGCATTGTGACCGTGCTTGGAAGGGAGGCT
CTCACCAAAGGGGCGCTGTGGGCAGTCTTTCTGCTCGCAGGGTCTGCCCTCCTCTGTGCC
GTGGTCACGGGCGTCATCTGGAGGCAGCCCGAGAGCAAGACCAAGCTCTCATTTAAGGTT
CCCTTCCTGCCAGTGCTCCCCATCCTGAGCATCTTCGTGAACGTCTATCTCATGATGCAG
CTGGACCAGGGCACCTGGGTCCGGTTTGCTGTGTGGATGCTGATAGGCTTCATCATCTAC
TTTGGCTATGGCCTGTGGCACAGCGAGGAGGCGTCCCTGGATGCCGACCAAGCAAGGACT
CCTGACGGCAACTTGGACCAGTGCAAGTGA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
X59155

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:13

# Macromolecular_Interacting_Partner_12_Locus:
13q12-q14

# Macromolecular_Interacting_Partner_12_SNPs:
rs2482090; rs2482089; rs2277451; rs34747283; rs34981623; rs34374153; rs1571784; rs914362; rs1984029; rs3013641; rs532568; rs1571786; rs1546534; rs537151; rs280922; rs485359; rs9551699; rs476506; rs166828; rs280933; rs280930; rs9551700; rs7997827; rs2989596; rs2277452; rs280923; rs1984030; rs11839516; rs866573; rs280936; rs2490264; rs579451; rs1877463; rs819388; rs7338758; rs6490412; rs280934; rs280918; rs280950; rs7328329; rs3013640; rs6490411; rs280928; rs9579412; rs9579400; rs659314; rs928352; rs11617418; rs819386; rs11616506; rs3011605; rs280927; rs9579402; rs645783; rs528336; rs2776949; rs476931; rs478085; rs617892; rs7998704; rs12428751; rs1018679; rs10870625; rs555913; rs928353; rs7981502; rs9579401; rs10454589; rs11618529; rs928354; rs2482087; rs9579397; rs2989594; rs11842773; rs3011624; rs819385; rs9314962; rs9579406; rs10454590; rs17661173; rs9579405; rs1275359; rs1275360; rs3011623; rs1756442; rs280919; rs645778; rs12427581; rs3803266; rs280924; rs9578106; rs2776408; rs1756444; rs595454; rs9579411; rs4769759; rs11838366; rs9578108; rs17073704; rs11843711; rs9314960; rs12864238; rs11843217; rs280926; rs2776948; rs166827; rs2669039; rs9579398; rs9508499; rs581455; rs521924; rs13378570; rs1756440; rs2669038; rs583804; rs9285066; rs2277453; rs41318021; rs533768; rs280954; rs10220050; rs9578107; rs1756439; rs9314961; rs9579407; rs280931; rs9579408; rs521122; rs280925; rs280935; rs1571785; rs17602182; rs9551696; rs7328185; rs280917; rs2989595; rs1124594; rs9579410; rs3011604; rs1707099; rs11840806; rs532499; rs1756438; rs9506206; rs9550482; rs17073661; rs4769760; rs280946; rs3803268; rs17073703; rs1756441; rs280947; rs2802249; rs2802240; rs2490266; rs3011625; rs2802252; rs2183717; rs2776955; rs2776959; rs6490410; rs11838370; rs3783259; rs2989592; rs2776960; rs2482093; rs1411928; rs2490265; rs2274837; rs2150689; rs6490409; rs2776956; rs2490267; rs2989593; rs3825536; rs883055; rs2776957; rs3783248; rs3783263; rs2150693; rs9579393; rs3783257; rs9578105; rs3783252; rs2776953; rs12428026; rs9579389; rs9579392; rs2776963; rs2802250; rs2150688; rs2802251; rs2150690; rs9579391; rs17073593; rs1018680; rs2482091; rs7993193; rs9578103; rs9579383; rs3783262; rs3783260; rs2236499; rs2482094; rs2776961; rs17073592; rs3011626; rs9550477; rs9579395; rs2026322; rs11842525; rs2150692; rs7336765; rs9579386; rs2802248; rs17603017; rs2026321; rs1018682; rs2482092; rs17602454; rs9578104; rs7318388; rs7338132; rs2802247; rs3783261; rs12875683; rs3783256; rs9579384; rs2776958; rs2150687; rs2183716; rs17660515; rs9579388; rs2150691; rs9579390; rs9508484; rs9579387; rs2776981; rs2776978; rs2802243; rs2776979; rs2802244; rs1005720; rs2776980; rs2802245; rs7991247; rs9578112; rs1005719; rs9578111; rs34072234; rs36015789; rs9508482; rs36125077; rs34941634; rs11315574; rs35198653; rs9551703; rs9551701; rs34054173; rs577666; rs280915; rs9579399; rs10712529; rs2989597; rs34597896; rs3184811; rs1330940; rs553271; rs9579382; rs1330941; rs15376; rs657993; rs8002439; rs280937; rs28595095; rs11305795; rs36114772; rs7320543; rs1756437; rs34719566; rs10219858; rs34218459; rs9508481; rs34369885; rs819389; rs34568566; rs280916; rs9551702; rs34978805; rs2989343; rs34967062; rs34479939; rs1756443; rs35992531; rs12868663; rs11348485; rs9579381; rs819392; rs34676366; rs7318650; rs9551698; rs34831702; rs280912; rs34563180; rs9578110; rs1756436; rs9579415; rs280955; rs9579414; rs3837577; rs36029139; rs1973624; rs34299140; rs34361702; rs35639325; rs11460300; rs35434476; rs35321601; rs9579404; rs34351045; rs280913; rs643986; rs3840002; rs36035912; rs34000939; rs2776950; rs9508497; rs34757816; rs34015769; rs9551697; rs860203; rs554904; rs34185884; rs9550483; rs3069134; rs34323634; rs522946; rs280929; rs35499262; rs3011607; rs34578457; rs35375275; rs35332203; rs9508490; rs2137395; rs34460584; rs3011608; rs819391; rs36006415; rs175973; rs558623; rs12872613; rs35196293; rs280932; rs12429742; rs645278; rs478688; rs28635114; rs7991883; rs634006; rs35694290; rs11276846; rs9508493; rs35321845; rs11315575; rs28420801; rs34318271; rs554179; rs9579403; rs9314963; rs36010538; rs11342640; rs13378143; rs2669037; rs9579413; rs35344478; rs2776409; rs280914; rs11305796; rs7491758; rs819390; rs678844; rs35926133; rs553069; rs11321368; rs4769763; rs9579396; rs35303712; rs9550481; rs33910194; rs280956; rs3011606; rs12164856; rs9508501; rs527380; rs4280096; rs34087661; rs28661387; rs11839594; rs615487; rs35061715; rs12868785; rs34109300; rs10601093; rs3066083; rs9579394; rs34156069; rs9551694; rs17660403; rs2776952; rs35186629; rs4769757; rs34496705; rs34724516; rs28510575; rs883056; rs7321163; rs34839020; rs35134959; rs914361; rs35662476; rs2776954; rs9579385; rs35457554; rs10685808; rs34847757; rs4002219; rs9551693; rs34286791; rs34296494; rs1018681; rs35597255; rs34444950; rs3066085; rs35860131; rs7358958; rs9551695; rs3837579; rs9550478; rs5802525; rs36066583; rs4002218; rs9579416; rs879427; rs9578102; rs7991463; rs11618507; rs11842710; rs172179; rs2482096; rs2482097; rs2490268; rs2776982; rs2776983; rs2776984; rs2776985; rs2776986; rs2802246; rs3011619; rs3011620; rs34778716; rs4769015; rs529696; rs558107; rs598281; rs7333364; rs7333533; rs7333701; rs7986532; rs7990747; rs7996343; rs7996508; rs7999739; rs7999905; rs8000157; rs882953; rs9508495; rs9508502; rs9551705; rs9578113; rs9578114; rs9579380; rs9579417; rs9579421; rs9579422; rs9579424; rs9579425; rs9805210; rs9805211

# Macromolecular_Interacting_Partner_12_General_References:
1718082; 1348489; 10485994

# Macromolecular_Interacting_Partner_12_References:
Not Available

# Macromolecular_Interacting_Partner_13_ID:
8881

# Macromolecular_Interacting_Partner_13_Name:
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

# Macromolecular_Interacting_Partner_13_Synonyms:
Amino acid transporter ATB0+; Solute carrier family 6 member 14

# Macromolecular_Interacting_Partner_13_Gene_Name:
SLC6A14

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Sodium and chloridedependent neutral and basic amino acid transporter B0+
MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVW
RFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGIT
MVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNK
GIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLA
LCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQ
SNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVF
AGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLG
LDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHF
CAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAI
FIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCC
RPASNWGPYLEQHRGERYKDMVDPKKEADHEIPTVSGSRKPE

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
642

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
72154

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
8.27

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
 Function:  transporter activity
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_13_Signals:
1-469

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
45-65
72-92
110-130
235-255
261-281
315-335
348-368
399-419
450-477
480-500
528-548
563-583

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
5732680

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
S6A14_HUMAN (Q9UN76)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
SLC6A14

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
SLC6A14

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:11047

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>1929 bp
ATGGACAAGTTGAAATGCCCGAGTTTCTTCAAGTGCAGGGAGAAGGAGAAAGTGTCGGCT
TCATCAGAGAATTTCCATGTTGGTGAAAATGATGAGAATCAGGACCGTGGTAACTGGTCC
AAAAAATCGGATTATCTTCTATCTATGATTGGATACGCAGTGGGATTAGGAAATGTGTGG
AGATTTCCATATCTGACCTACAGCAATGGTGGAGGCGCCTTCTTGATACCTTATGCAATT
ATGTTAGCATTGGCTGGTTTACCTTTGTTCTTTCTGGAGTGTTCACTGGGACAATTTGCT
AGCTTAGGTCCAGTTTCAGTTTGGAGGATTCTTCCATTGTTTCAAGGTGTGGGAATTACA
ATGGTCCTGATCTCCATTTTTGTGACAATCTATTACAATGTCATAATTGCCTATAGTCTT
TACTACATGTTTGCTTCTTTTCAAAGTGAACTACCATGGAAAAATTGTTCTTCGTGGTCA
GATAAAAACTGTAGCAGATCACCAATAGTAACTCACTGTAATGTGAGTACAGTGAATAAA
GGAATACAAGAGATCATCCAAATGAATAAAAGCTGGGTAGACATCAACAATTTTACCTGC
ATCAACGGCAGTGAAATTTATCAGCCAGGGCAGCTTCCCAGTGAACAATATTGGAATAAA
GTGGCGCTCCAACGGTCAAGTGGAATGAATGAGACTGGAGTAATTGTTTGGTATTTAGCA
CTTTGTCTTCTTCTGGCTTGGCTCATAGTTGGAGCAGCACTATTTAAAGGAATCAAATCG
TCTGGCAAGGTGGTATATTTTACAGCTCTTTTCCCCTATGTGGTCCTACTCATCCTGTTA
GTACGAGGTGCAACTCTGGAGGGTGCTTCAAAAGGCATTTCATACTATATTGGAGCCCAG
TCAAATTTTACAAAACTTAAGGAAGCTGAGGTATGGAAAGATGCTGCCACTCAGATATTT
TACTCCCTTTCAGTGGCTTGGGGTGGCTTAGTTGCTCTATCATCTTACAATAAGTTCAAA
AACAACTGCTTCTCTGATGCCATTGTGGTTTGTTTGACAAACTGTCTCACTAGCGTGTTT
GCTGGATTTGCTATTTTTTCTATATTGGGACACATGGCCCATATATCTGGAAAGGAAGTT
TCTCAAGTTGTAAAATCAGGTTTTGATTTGGCATTCATTGCCTATCCAGAGGCTCTAGCC
CAACTCCCAGGTGGTCCATTTTGGTCCATATTATTTTTTTTCATGCTTTTAACTTTGGGT
CTCGATTCTCAGTTTGCTTCGATTGAAACGATCACAACAACAATTCAAGATTTATTTCCC
AAAGTGATGAAGAAAATGAGGGTTCCCATAACTTTGGGCTGCTGCTTGGTTTTGTTTCTC
CTTGGTCTCGTCTGTGTGACTCAGGCTGGAATTTACTGGGTTCATCTGATTGACCACTTC
TGTGCTGGATGGGGCATTTTAATTGCAGCTATACTGGAGCTAGTTGGAATCATCTGGATT
TATGGAGGGAACAGATTCATTGAGGATACAGAAATGATGATTGGAGCAAAGAGGTGGATA
TTCTGGCTATGGTGGAGAGCTTGCTGGTTTGTAATTACGCCTATCCTTTTGATTGCAATA
TTTATCTGGTCATTGGTGCAATTTCATAGACCTAATTATGGCGCAATTCCATACCCTGAC
TGGGGAGTTGCTTTAGGCTGGTGTATGATTGTTTTCTGCATTATTTGGATACCAATTATG
GCTATCATAAAAATAATTCAGGCTAAAGGAAACATCTTTCAACGCCTTATAAGTTGCTGC
AGACCAGCTTCTAACTGGGGTCCATACCTGGAACAACATCGTGGGGAAAGATATAAAGAC
ATGGTAGATCCTAAAAAAGAGGCTGACCATGAAATACCTACTGTTAGTGGCAGCAGAAAA
CCGGAATGA

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
AF151978

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_13_Locus:
Xq23-q24

# Macromolecular_Interacting_Partner_13_SNPs:
rs12720074; rs2011162; rs5905179; rs12710570; rs5905289; rs2011198; rs2312055; rs2032525; rs5905176; rs5905284; rs7059155; rs2071877; rs4824325; rs10217924; rs5905178; rs6608646; rs12392462; rs2312057; rs12391221; rs17242824; rs5905288; rs12559530; rs10218102; rs10521579; rs12710569; rs10521578; rs5905285; rs5952101; rs12720080; rs12720088; rs5952099; rs12720083; rs5905177; rs4824358; rs4824324; rs12720076; rs4824359; rs12720084; rs12720079; rs5952103; rs2312056; rs12720089; rs17095419; rs12393509; rs4824323; rs2312054; rs7052454; rs12710568; rs12720073; rs12834312; rs3788766; rs5905283; rs12720085; rs28523889; rs6608648; rs11350870; rs34685017; rs28699570; rs12720092; rs28628632; rs12720078; rs5952174; rs35604008; rs5952104; rs5905287; rs6608645; rs12388847; rs10629819; rs12720087; rs12720091; rs35269408; rs17308739; rs3043424; rs35542990; rs5952100; rs5952102; rs35201069; rs6651554; rs12720077; rs10218234; rs6608647; rs12858125; rs34117081; rs5952175; rs12720082; rs34490652; rs4068397; rs7066547; rs7054956; rs12832551; rs10218418; rs12720075; rs12720086; rs12720090; rs35315031; rs7062559; rs10218017; rs12390279; rs12833869; rs12835480; rs12839137; rs12844003; rs17308697; rs2103697; rs2301451; rs5952181; rs6520234; rs6608511; rs6608514; rs6608644; rs6608650

# Macromolecular_Interacting_Partner_13_General_References:
10446133

# Macromolecular_Interacting_Partner_13_References:
Not Available

End of HMDB00161

Beginning of HMDB00162
# Accession_No:
HMDB00162

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-19 12:27:13

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
L-Proline

# Description:
L-Proline is one of the twenty amino acids which are used in living organisms as the building blocks of proteins. Proline is sometimes called an imino acid, although the IUPAC definition of an imine requires a carbon-nitrogen double bond. In biological terminology, however, the category "amino acids" is generally taken to include proline.  Proline is a non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.

# Synonyms:
(-)-(S)-Proline; (-)-2-Pyrrolidinecarboxylate; (-)-2-Pyrrolidinecarboxylic acid; (-)-Proline; (R)-Pyrrolidine-2-carboxylate; (R)-Pyrrolidine-2-carboxylic acid; (S)-(-)-Proline; (S)-(-)-Pyrrolidine-2-carboxylate; (S)-(-)-Pyrrolidine-2-carboxylic acid; (S)-2-Carboxypyrrolidine; (S)-2-Pyrralidinecarboxylate; (S)-2-Pyrralidinecarboxylic acid; (S)-2-Pyrrolidinecarboxylate; (S)-2-Pyrrolidinecarboxylic acid; (S)-Proline; 2-Pyrrolidinecarboxylate; 2-Pyrrolidinecarboxylic acid; Proline

# Chemical_IUPAC_Name:
(2S)-pyrrolidine-2-carboxylic acid

# Chemical_Formula:
C5H9NO2

# Chemical_Structure:
tbl_chemical:::HMDB00162_ZOOM.png:::119283227168243588

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00162_THUMB.png:::11928322701039098

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
secondary amine; secondary aliphatic amine (dialkylamine); carboxylic acid; heterocyclic compound; alpha-aminoacid

# Taxonomy_Biofunction:
Component of Arginine and proline metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
115.06333

# Molecular_Weight_Avg:
115.13046

# Smiles_String_isomeric:
OC(=O)[C@@H]1CCCN1

# Smiles_String_canonical:
OC(=O)C1CCCN1

# KEGG_Compound_ID:
C00148

# BioCyc_ID:
PRO

# PubChem_CID:
145742

# PubChem_SID:
828275; 832624; 841800; 723505; 828272; 6436535; 3135874; 7887166; 10248984; 6436537; 8144250; 821453; 747388; 7890050; 7847103; 821378; 8026812; 3448; 838056; 10508477; 4253464; 10318165; 838059; 6436528

# OMIM_ID:
176770; 239500

# Metagene_ID:
Not Available

# BiGG_ID:
34042

# Wikipedia_ID:
L-Proline

# METLIN_ID:
29

# Ref_ID:
12101068; 11903317; 3698278; 3316273; 12297216; 10082503; 991465; 240452; 533224; 3943105; 3364629; 1055415; 6142902; 12097436; 136295; 11510941

# ChEBI_ID:
17203

# CAS_Registry_Number:
147-85-3

# InChI:
InChI=1/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1

# Synthesis_Reference:
Synthesis of L-proline from L-glutamine.     Itoh, Tamio.    Univ. Osaka,    Bulletin of the Chemical Society of Japan  (1963),  36(1),  25-9

# Melting_Point:
221 oC

# Melting_Point_predicted:
80.8 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
162.0 mg/mL [MERCK INDEX (1996)]

# H2O_Solubility_Predicted:
365.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-2.54 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-2.70 [Predicted by ALOGPS]; -2.4 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::L-Proline.pdf:::1132562209062915277

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::L-Proline.mol:::1132723811218554086

# SDF_File_[Text]:
tbl_chemical:::HMDB00162.sdf:::119283226675144125

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00162.pdb:::119283226872833813

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041016_P00_04_HW_1DP_presat.png:::114849414152576518

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041016_P00_04_HW_1DP_presat.zip:::114849434555974097

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041016_P00_04_HW_1DP_Assigned.png:::116415088337610140

# C_NMR_Spectra:
tbl_cnmr:::041016_P00_04_HW_1DC_19.jpg:::114168460090929299

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041016_P00_04_HW_1DC_19.zip:::114168460086368205

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041016_P00_04_HW_1DC_19_Assigned.jpg:::114332849423347627

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041016_P00_04_HW_2DHSQC_74.jpg:::114495949647135042

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041016_P00_04_HW_2DHSQC_74.zip:::114495949648292799

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041016_P00_04_HW_2DHSQC_74_Assigned.jpg:::114495949662426421

# Predicted_H_NMR_Spectrum:
tbl_chemical:::L-Proline.gif:::1132732116078990640

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00162_peaks.txt:::1156309587559103207

# Predicted_C_NMR_Spectrum:
tbl_chemical:::L-Proline_C.gif:::1132737706067405748

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00162_peaks.txt:::1156310777211860012

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00162L.png:::117555262937369668; Medium Energy:tbl_ms:::HMDB00162M.png:::117555268245310242; High Energy:tbl_ms:::HMDB00162H.png:::117555271611517442

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000047.png:::116890824432849013

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000047.txt:::116890824432886323

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000047.png:::116890824398495294

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000047.txt:::116890824432825180

# Cellular_Location:
Cytoplasm; endoplasmic reticulum; Extracellular; lysosome; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Urine	2.171 (0.0658-4.276)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Blood	168.0 (108.0-228.0)	umol/L	Adult:>18_yrs_old	Both	Normal	12297216
Blood	198.0 +/- 63.0	umol/L	Children:1-13_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	239.0 +/- 70.0	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	168.0 +/- 49.0	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	230.0 +/- 75.0	umol/L	Newborn:0-30_days_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	 4.0 (0 - 8.0)	umol/L	Adult:>18_yrs_old	Both	Normal	11510941
Saliva	>10	umol/L	Adult:>18_yrs_old	Both	Normal	12097436


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Cirrhosis; End-stage Renal Disease (ESRD); Neonatal Maple syrup urine Disease (MSUD); Neonatal Phenylketonuria

# Pathway_Names:
Porphyrin and chlorophyll metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00860

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
6147

# Metabolic_Enzyme_1_Name:
Cytosol aminopeptidase

# Metabolic_Enzyme_1_Synonyms:
Leucine aminopeptidase; LAP; Leucyl aminopeptidase; Leucine aminopeptidase 3; Proline aminopeptidase; Prolyl aminopeptidase; Peptidase S

# Metabolic_Enzyme_1_Gene_Name:
LAP3

# Metabolic_Enzyme_1_Protein_Sequence:
>Cytosol aminopeptidase
MFLLPLPAAGRVVVRRLAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFD
KLLAGKLRETLNISGPPLKAGKTRTFYGLHQDFPSVVLVGLGKKAAGIDEQENWHEGKEN
IRAAVAAGCRQIQDLELSSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKKKMAVSAKLYGS
GDQEAWQKGVLFASGQNLARQLMETPANEMTPTRFAEIIEKNLKSASSKTEVHIRPKSWI
EEQAMGSFLSVAKGSDEPPVFLEIHYKGSPNANEPPLVFVGKGITFDSGGISIKASANMD
LMRADMGGAATICSAIVSAAKLNLPINIIGLAPLCENMPSGKANKPGDVVRAKNGKTIQV
DNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFE
ASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHL
DIAGVMTNKDEVPYLRKGMTGRPTRTLIEFLLRFSQDNA

# Metabolic_Enzyme_1_Number_of_Residues:
519

# Metabolic_Enzyme_1_Molecular_Weight:
56167

# Metabolic_Enzyme_1_Theoretical_pI:
8.05

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  manganese ion binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  exopeptidase activity
Function:  aminopeptidase activity
Function:  leucyl aminopeptidase activity
 ||
>>>
Process:  cellular protein metabolism
Process:  proteolysis
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

# Metabolic_Enzyme_1_Pathway:
map00330  Arginine and proline metabolism

# Metabolic_Enzyme_1_Reaction:
Release of N-terminal proline from a peptide

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00883:Peptidase_M17;
PF02789:Peptidase_M17_N

# Metabolic_Enzyme_1_Signals:
1-18

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.4.11.1;EC 3.4.11.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
4335941

# Metabolic_Enzyme_1_SwissProt_ID:
AMPL_HUMAN (P28838)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
LAP3

# Metabolic_Enzyme_1_Geneatlas_id:
LAP3

# Metabolic_Enzyme_1_hgnc_id:
HGNC:18449

# Metabolic_Enzyme_1_PDB_ID:
1LAP

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1560 bp
ATGTTCTTGCTGCCTCTTCCGGCTGCGGGGCGAGTAGTCGTCCGACGTCTGGCCGTAGTA
CGTTCTGGGAGCCGGAGTCTCTCCACCGCAGACATGACGAAGGGCCTTGTTTTAGGAATC
TATTCCAAAGAAAAAGAAGATGATGTGCCACAGTTCACAAGTGCAGGAGAGAATTTTGAT
AAATTGTTAGCTGGAAAGCTGAGAGAGACTTTGAACATATCTGGACCACCTCTGAAGGCA
GGGAAGACTCGAACCTTTTATGGTCTGCATCAGGACTTCCCCAGCGTGGTGCTAGTTGGC
CTCGGCAAAAAGGCAGCTGGAATCGACGAACAGGAAAACTGGCATGAAGGCAAAGAAAAC
ATCAGAGCTGCTGTTGCAGCGGGGTGCAGGCAGATTCAAGACCTGGAGCTCTCGTCTGTG
GAGGTGGATCCCTGTGGAGACGCTCAGGCTGCTGCGGAGGGAGCGGTGCTTGGTCTCTAT
GAATACGATGACCTAAAGCAAAAAAAGAAGATGGCTGTGTCGGCAAAGCTCTATGGAAGT
GGGGATCAGGAGGCCTGGCAGAAAGGAGTCCTGTTTGCTTCTGGGCAGAACTTGGCACGC
CAATTGATGGAGACGCCAGCCAATGAGATGACGCCAACCAGATTTGCCGAAATTATTGAG
AAGAATCTCAAAAGTGCTAGTAGTAAAACCGAGGTCCATATCAGACCCAAGTCTTGGATT
GAGGAACAGGCAATGGGATCATTCCTCAGTGTGGCCAAAGGATCTGACGAGCCCCCAGTC
TTCTTGGAAATTCACTACAAAGGCAGCCCCAATGCAAACGAACCACCCCTGGTGTTTGTT
GGGAAAGGAATTACCTTTGACAGTGGTGGTATCTCCATCAAGGCTTCTGCAAATATGGAC
CTCATGAGGGCTGACATGGGAGGAGCTGCAACTATATGCTCAGCCATCGTGTCTGCTGCA
AAGTTAAATTTGCCCATTAATATTATAGGTCTGGCCCCTCTTTGTGAAAATATGCCCAGC
GGCAAGGCCAACAAGCCGGGGGATGTTGTTAGAGCCAAAAACGGGAAGACCATCCAGGTT
GATAACACTGATGCTGAGGGGAGGCTCATACTGGCTGATGCGCTCTGTTACGCACACACG
TTTAACCCGAAGGTCATCCTCAATGCCGCCACCTTAACAGGTGCCATGGATGTAGCTTTG
GGATCAGGTGCCACTGGGGTCTTTACCAATTCATCCTGGCTCTGGAACAAACTCTTCGAG
GCCAGCATTGAAACAGGGGACCGTGTCTGGAGGATGCCTCTCTTCGAACATTATACAAGA
CAGGTTGTAGATTGCCAGCTTGCTGATGTTAACAACATTGGAAAATACAGATCTGCAGGA
GCATGTACAGCTGCAGCATTCCTGAAAGAATTCGTAACTCATCCTAAGTGGGCACATTTA
GACATAGCAGGCGTGATGACCAACAAAGATGAAGTTCCCTATCTACGGAAAGGCATGACT
GGGAGGCCCACAAGGACTCTCATTGAGTTCTTACTTCGTTTCAGTCAAGACAATGCTTAG


# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF061738

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_1_Locus:
4p15.32

# Metabolic_Enzyme_1_SNPs:
rs7697250; rs12507986; rs3733576; rs1476836; rs2010053; rs4698622; rs740887; rs10008445; rs2058336; rs1003413; rs6812675; rs3775927; rs7670500; rs6815977; rs2315645; rs10008598; rs4698629; rs4698628; rs7658240; rs12500912; rs3775924; rs6813071; rs3796813; rs6449313; rs10005380; rs4698625; rs10939736; rs4698626; rs3775925; rs3775926; rs3815414; rs1860590; rs3775923; rs6449312; rs12511844; rs4698620; rs4698627; rs6449315; rs17499929; rs4698623; rs12500947; rs7658447; rs16895245; rs16895290; rs3796814; rs12509306; rs11942938; rs9998130; rs7675735; rs7680984; rs1860589; rs4698621; rs9291657; rs16895279; rs4698619; rs16895259; rs16895273; rs10008337; rs16895280; rs10002358; rs3796812; rs6831013; rs6826073; rs12507810; rs16895270; rs16895296; rs11737120; rs4698624; rs16895265; rs11730717; rs16895253; rs6843095; rs12650220; rs10034104; rs12503909; rs6854266; rs16895277; rs10939738; rs6820910; rs2079891; rs1860591; rs6851783; rs6825133; rs2098151; rs10019482; rs1860592; rs2079892; rs10939735; rs3175026; rs11542523; rs13123846; rs1059847; rs1059826; rs1059835; rs28528916; rs11333479; rs5856431; rs34802213; rs16895267; rs6843530; rs10609509; rs10719442; rs35117415; rs35009003; rs7677305; rs34331308; rs13128351; rs13147018; rs11934098; rs35155062; rs35715410; rs5856434; rs11929883; rs35979895; rs41268397; rs2276960; rs36047159; rs7693502; rs9995197; rs10580590; rs5856433; rs28441502; rs10591168; rs11287207; rs729813; rs35750549; rs34197304; rs34183270; rs35153429; rs35150824; rs3836718; rs36212776; rs28558603; rs10939739; rs2302395; rs5856432; rs7677109; rs41268395; rs16895282; rs7657414; rs10003291; rs13132128; rs35467396; rs10585004; rs7672369; rs3775928; rs34903730; rs11273848; rs3179267; rs3180262; rs35655433; rs1006722; rs1006723; rs10939733; rs10939734; rs10939740; rs12233712; rs12503098; rs12648232; rs13127157; rs2286772; rs2286773; rs34069726; rs3846356; rs3890403; rs4479701; rs4590022; rs4642241; rs4698630; rs6449311; rs7697889

# Metabolic_Enzyme_1_General_References:
1908238

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5538

# Metabolic_Enzyme_2_Name:
Pyrroline-5-carboxylate reductase 1

# Metabolic_Enzyme_2_Synonyms:
P5CR 1; P5C reductase 1

# Metabolic_Enzyme_2_Gene_Name:
PYCR1

# Metabolic_Enzyme_2_Protein_Sequence:
>Pyrroline5carboxylate reductase 1
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETV
QHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRC
MTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAY
AFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIH
ALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTAL
SPSGHTKLLPRSLAPAGKD

# Metabolic_Enzyme_2_Number_of_Residues:
319

# Metabolic_Enzyme_2_Molecular_Weight:
33361

# Metabolic_Enzyme_2_Theoretical_pI:
7.69

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
Function:  pyrroline-5-carboxylate reductase activity
 ||
>>>
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  proline metabolism
Process:  proline biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
L-proline + NAD(P)(+) = 1-pyrroline-5- carboxylate + NAD(P)H

# Metabolic_Enzyme_2_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_2_Reaction:
L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF03807:F420_oxidored

# Metabolic_Enzyme_2_Signals:
1-26

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.5.1.2

# Metabolic_Enzyme_2_GenBank_ID_Protein:
189498

# Metabolic_Enzyme_2_SwissProt_ID:
P5CR1_HUMAN (P32322)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
PYCR1

# Metabolic_Enzyme_2_Geneatlas_id:
PYCR1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:9721

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>960 bp
ATGAGCGTGGGCTTCATCGGCGCTGGCCAGCTGGCTTTTGCCCTGGCCAAGGGCTTCACA
GCAGCAGGCGTCTTGGCTGCCCACAAGATAATGGCTAGCTCCCCAGACATGGACCTGGCC
ACAGTTTCTGCTCTCAGGAAGATGGGGGTGAAGTTGACACCCCACAACAAGGAGACGGTG
CAGCACAGTGATGTGCTCTTCCTGGCTGTGAAGCCACACATCATCCCCTTCATCCTGGAT
GAAATAGGCGCCGACATTGAGGACAGACACATTGTGGTGTCCTGCGCGGCCGGCGTCACC
ATCAGCTCCATTGAGAAGAAGCTGTCAGCGTTTCGGCCAGCCCCCAGGGTCATCCGCTGC
ATGACCAACACTCCAGTCGTGGTGCGGGAGGGGGCCACCGTGTATGCCACAGGCACGCAC
GCCCAGGTGGAGGACGGGAGGCTCATGGAGCAGCTGCTGAGCACGGTGGGCTTCTGCACG
GAGGTGGAAGAGGACCTGATTGATGCCGTCACGGGGCTCAGTGGCAGCGGCCCCGCCTAC
GCATTCACAGCCCTGGATGCCCTGGCTGATGGGGGTGTGAAGATGGGACTTCCAAGGCGC
CTGGCAGTCCGCCTCGGGGCCCAGGCCCTCCTGGGGGCTGCCAAGATGCTGCTGCACTCA
GAACAGCACCCAGGCCAGCTCAAGGACAACGTCAGCTCTCCTGGTGGGGCCACCATCCAT
GCCTTGCATGTGCTGGAGAGTGGGGGCTTCCGCTCCCTGCTCATCAACGCTGTGGAGGCC
TCCTGCATCCGCACACGGGAGCTGCAGTCCATGGCTGACCAGGAGCAGGTGTCACCAGCC
GCCATCAAGAAGACCATCCTGGACAAGGTGAAGCTGGACTCCCCTGCAGGGACCGCTCTG
TCGCCTTCTGGCCACACCAAGCTGCTCCCCCGCAGCCTGGCCCCAGCGGGCAAGGATTGA


# Metabolic_Enzyme_2_GenBank_ID_Gene:
M77836

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_2_Locus:
17q25.3

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
1730675

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5537

# Metabolic_Enzyme_3_Name:
Prolyl 4-hydroxylase subunit alpha-2 precursor

# Metabolic_Enzyme_3_Synonyms:
4-PH alpha-2; Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-2 subunit

# Metabolic_Enzyme_3_Gene_Name:
P4HA2

# Metabolic_Enzyme_3_Protein_Sequence:
>Prolyl 4hydroxylase subunit alpha2 precursor
MKLWVSALLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKS
WANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQR
QFFPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEG
DYYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSH
ERAGGNLRYFEQLLEEEREKTLTNQTEAELATPEGIYERPVDYLPERDVYESLCRGEGVK
LTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPK
LARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVAN
YGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKK
GTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGSTEVD

# Metabolic_Enzyme_3_Number_of_Residues:
535

# Metabolic_Enzyme_3_Molecular_Weight:
60903

# Metabolic_Enzyme_3_Theoretical_pI:
5.43

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the posttranslational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins

# Metabolic_Enzyme_3_Pathway:
map00330  Arginine and proline metabolism

# Metabolic_Enzyme_3_Reaction:
procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF03171:2OG-FeII_Oxy;
PF08336:P4Ha_N;
PF07719:TPR_2

# Metabolic_Enzyme_3_Signals:
1-21

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.14.11.2

# Metabolic_Enzyme_3_GenBank_ID_Protein:
2439985

# Metabolic_Enzyme_3_SwissProt_ID:
P4HA2_HUMAN (O15460)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
P4HA2

# Metabolic_Enzyme_3_Geneatlas_id:
P4HA2

# Metabolic_Enzyme_3_hgnc_id:
HGNC:8547

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum lumen

# Metabolic_Enzyme_3_Gene_Sequence:
>1608 bp
ATGAAACTCTGGGTGTCTGCATTGCTGATGGCCTGGTTTGGTGTCCTGAGCTGTGTGCAG
GCCGAATTCTTCACCTCTATTGGGCACATGACTGACCTGATTTATGCAGAGAAAGAGCTG
GTGCAGTCTCTGAAAGAGTACATCCTTGTGGAGGAAGCCAAGCTTTCCAAGATTAAGAGC
TGGGCCAACAAAATGGAAGCCTTGACTAGCAAGTCAGCTGCTGATGCTGAGGGCTACCTG
GCTCACCCTGTGAATGCCTACAAACTGGTGAAGCGGCTAAACACAGACTGGCCTGCGCTG
GAGGACCTTGTCCTGCAGGACTCAGCTGCAGGTTTTATCGCCAACCTCTCTGTGCAGCGG
CAGTTCTTCCCCACTGATGAGGACGAGATAGGAGCTGCCAAAGCCCTGATGAGACTTCAG
GACACATACAGGCTGGACCCAGGCACAATTTCCAGAGGGGAACTTCCAGGAACCAAGTAC
CAGGCAATGCTGAGTGTGGATGACTGCTTTGGGATGGGCCGCTCGGCCTACAATGAAGGG
GACTATTATCATACGGTGTTGTGGATGGAGCAGGTGCTAAAGCAGCTTGATGCCGGGGAG
GAGGCCACCACAACCAAGTCACAGGTGCTGGACTACCTCAGCTATGCTGTCTTCCAGTTG
GGTGATCTGCACCGTGCCCTGGAGCTCACCCGCCGCCTGCTCTCCCTTGACCCAAGCCAC
GAACGAGCTGGAGGGAATCTGCGGTACTTTGAGCAGTTATTGGAGGAAGAGAGAGAAAAA
ACGTTAACAAATCAGACAGAAGCTGAGCTAGCAACCCCAGAAGGCATCTATGAGAGGCCT
GTGGACTACCTGCCTGAGAGGGATGTTTACGAGAGCCTCTGTCGTGGGGAGGGTGTCAAA
CTGACACCCCGTAGACAGAAGAGGCTTTTCTGTAGGTACCACCATGGCAACAGGGCCCCA
CAGCTGCTCATTGCCCCCTTCAAAGAGGAGGACGAGTGGGACAGCCCGCACATCGTCAGG
TACTACGATGTCATGTCTGATGAGGAAATCGAGAGGATCAAGGAGATCGCAAAACCTAAA
CTTGCACGAGCCACCGTTCGTGATCCCAAGACAGGAGTCCTCACTGTCGCCAGCTACCGG
GTTTCCAAAAGCTCCTGGCTAGAGGAAGATGATGACCCTGTTGTGGCCCGAGTAAATCGT
CGGATGCAGCATATCACAGGGTTAACAGTAAAGACTGCAGAATTGTTACAGGTTGCAAAT
TATGGAGTGGGAGGACAGTATGAACCGCACTTCGACTTCTCTAGGAATGATGAGCGAGAT
ACTTTCAAGCATTTAGGGACGGGGAATCGTGTGGCTACTTTCTTAAACTACATGAGTGAT
GTAGAAGCTGGTGGTGCCACCGTCTTCCCTGATCTGGGGGCTGCAATTTGGCCTAAGAAG
GGTACAGCTGTGTTCTGGTACAACCTCTTGCGGAGCGGGGAAGGTGACTACCGAACAAGA
CATGCTGCCTGCCCTGTGCTTGTGGGCTGCAAGTGGGTCTCCAATAAGTGGTTCCATGAA
CGAGGACAGGAGTTCTTGAGACCTTGTGGATCAACAGAAGTTGACTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U90441

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_3_Locus:
5q31

# Metabolic_Enzyme_3_SNPs:
rs7733814; rs157578; rs154486; rs6596070; rs4705849; rs4705926; rs154487; rs7733502; rs11952765; rs128738; rs156029; rs283753; rs246107; rs152047; rs152051; rs156025; rs75189; rs3805681; rs3828675; rs154484; rs3749756; rs3805683; rs4361509; rs2278398; rs12653783; rs7703009; rs12657965; rs156023; rs17618350; rs3792894; rs10052046; rs152050; rs7701237; rs154483; rs156030; rs10075459; rs156027; rs283763; rs17165741; rs159903; rs152049; rs2301579; rs154485; rs188199; rs2081274; rs152048; rs17165762; rs17618604; rs10520127; rs3214098; rs152053; rs159899; rs157577; rs3805685; rs156032; rs246108; rs156033; rs156034; rs7702160; rs3805684; rs1126979; rs1126978; rs3211283; rs28752075; rs41298340; rs34435009; rs15826; rs35313991; rs1008564; rs35334449; rs34045212; rs35183308; rs392587; rs182092; rs185857; rs28692687; rs35974099; rs36094565; rs185858; rs3840353; rs10656798; rs176112; rs13186538; rs3991665; rs36046040; rs28542593; rs35791773; rs2048473; rs172231; rs34410092; rs35792165; rs1987404; rs184015; rs415986; rs175091; rs13166357; rs34132804; rs34157941; rs390763; rs5871448; rs182249; rs13166329; rs35884065; rs446415; rs13186642; rs13179264; rs10065782; rs424089; rs205547; rs34601928; rs35102688; rs13166927; rs166902; rs35194004; rs35497617; rs13166479; rs364504; rs34049016; rs13166932; rs156026; rs185616; rs6875603; rs34637952; rs35626181; rs35536064; rs10036208; rs10051679; rs10058655; rs11741341; rs11749843; rs11952065; rs11955347; rs13188221; rs13190293; rs1511675; rs152055; rs156031; rs156036; rs17165720; rs17165721; rs2077380; rs2089855; rs2405271; rs408931; rs6896703; rs743563; rs9791170

# Metabolic_Enzyme_3_General_References:
9211872; 11606192; 12975309

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5540

# Metabolic_Enzyme_4_Name:
Pyrroline-5-carboxylate reductase 2

# Metabolic_Enzyme_4_Synonyms:
P5CR 2; P5C reductase 2

# Metabolic_Enzyme_4_Gene_Name:
PYCR2

# Metabolic_Enzyme_4_Protein_Sequence:
>Pyrroline5carboxylate reductase 2
MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETV
KHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRC
MTNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAY
AFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIH
ALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTL
TPSSPGKLLTRSLALGGKKD

# Metabolic_Enzyme_4_Number_of_Residues:
320

# Metabolic_Enzyme_4_Molecular_Weight:
33638

# Metabolic_Enzyme_4_Theoretical_pI:
7.87

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
Function:  pyrroline-5-carboxylate reductase activity
 ||
>>>
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  proline metabolism
Process:  proline biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
L-proline + NAD(P)(+) = 1-pyrroline-5- carboxylate + NAD(P)H

# Metabolic_Enzyme_4_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_4_Reaction:
L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF03807:F420_oxidored

# Metabolic_Enzyme_4_Signals:
1-16

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.5.1.2

# Metabolic_Enzyme_4_GenBank_ID_Protein:
33150582

# Metabolic_Enzyme_4_SwissProt_ID:
P5CR2_HUMAN (Q96C36)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
PYCR2

# Metabolic_Enzyme_4_Geneatlas_id:
PYCR2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:30262

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>963 bp
ATGAGCGTGGGCTTCATCGGGGCCGGCCAGCTGGCTAATGCTCTGGCGCGGGGCTTCACG
GCCGCAGCATTCCTGTCGGCTCACAAGATAATAGCCAGCTCCCCAGAAATGAACCTGCCC
ACGGTGTCCGCGCTCAGGAAGATGGGTGTGAACCTGACACGCAGCAACAAGGAGACGGTG
AAGCACAGCGACGTCCTGTTTCTGGCTGTGAAGCACATTATCATCCCCTTCATCCTGGAT
GAGATTGGGGCCGACGTGCAAGCCAGACACATCGTGGTCTCCTGTGCGGCTGGTGTCACC
ATCAGCTCTGTGGAGAAGAAGCTGATGGCATTCCAGCCAGCCCCCAAAGTGATTCGCTGC
ATGACCAACACACCTGTGGTAGTGCAGGAAGGCGCTACAGTGTACGCCACGGGCACCCAT
GCCCTGGTGGAGGATGGGCAGCTCCTGGAGCAGCTCATGAGCAGCGTGGGCTTCTGCACT
GAGGTGGAAGAGGACCTCATCGATGCCGTCACGGGGCTCAGTGGCAGCGGGCCTGCCTAT
GCATTCATGGCTCTGGACGCATTGGCTGATGGTGGGGTGAAGATGGGTTTGCCACGGCGC
CTGGCAATCCAACTCGGGGCCCAGGCTTTGCTGGGAGCTGCCAAGATGCTGCTGGACTCG
GAGCAGCATCCATGCCAGCTTAAGGACAATGTCTGCTCCCCTGGGGGAGCCACCATCCAC
GCCCTGCACTTTCTAGAGAGTGGGGGCTTCCGCTCTCTGCTCATCAATGCAGTTGAGGCC
TCCTGTATCCGAACACGAGAGCTACAGTCCATGGCCGACCAAGAAAAGATCTCCCCAGCT
GCCCTTAAGAAGACCCTCTTAGACAGAGTGAAGCTGGAATCCCCCACAGTCTCCACACTG
ACCCCCTCCAGCCCAGGGAAGCTCCTCACAAGAAGCCTGGCCCTGGGAGGCAAGAAGGAC
TAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF087859

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_4_Locus:
1q42.12

# Metabolic_Enzyme_4_SNPs:
rs14868; rs10915898; rs10915897; rs10915899; rs11543043; rs11543044; rs11543045; rs34126730; rs28364597; rs11550734; rs1065727; rs12081368; rs2897451; rs35269575; rs41307726; rs12047383; rs3830909; rs3753671; rs360064; rs6661737; rs4546887; rs3753672; rs11335661; rs35240460; rs10799329; rs10915902; rs12078868; rs12354244; rs360066; rs3820237; rs425425

# Metabolic_Enzyme_4_General_References:
Not Available

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5839

# Metabolic_Enzyme_5_Name:
Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase

# Metabolic_Enzyme_5_Synonyms:
Glutamate--tRNA ligase; Prolyl-tRNA synthetase; Proline--tRNA ligase]

# Metabolic_Enzyme_5_Gene_Name:
EPRS

# Metabolic_Enzyme_5_Protein_Sequence:
>Bifunctional aminoacyltRNA synthetase Includes: GlutamyltRNA synthetase
MEHTEIDHWLEFSATKLSSCDSFTSTINELNHCLSLRTYLVGNSLSLADLCVWATLKGNA
AWQEQLKQKKAPVHVKRWFGFLEAQQAFQSVGTKWDVSTTKARVAPEKKQDVGKFVELPG
AEMGKVTVRFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEKEDFEKVI
LEDVAMLHIKPDQFTYTSDHFETIMKYAEKLIQEGKAYVDDTPAEQMKAEREQRIESKHR
KNPIEKNLQMWEEMKKGSQFGHSCCLRAKIDMSSNNGCMRDPTLYRCKIQPHPRTGNKYN
VYPTYDFACPIVDSIEGVTHALRTTEYHDRDEQFYWIIEALGIRKPYIWEYSRLNLNNTV
LSKRKLTWFVNEGLVDGWDDPRFPTVRGVLRRGMTVEGLKQFIAAQGSSRSVVNMEWDKI
WAFNKKVIDPVAPRYVALLKKEVIPVNVPEAQEEMKEVAKHPKNPEVGLKPVWYSPKVFI
EGADAETFSEGEMVTFINWGNLNITKIHKNADGKIISLDAKFNLENKDYKKTTKVTWLAE
TTHALPIPVICVTYEHLITKPVLGKDEDFKQYVNKNSKHEELMLGDPCLKDLKKGDIIQL
QRRGFFICDQPYEPVSPYSCKEAPCVLIYIPDGHTKEMPTSGSKEKTKVEATKNETSAPF
KERPTPSLNNNCTTSEDSLVLYNRVAVQGDVVRELKAKKAPKEDVDAAVKQLLSLKAEYK
EKTGQEYKPGNPPAEIGQNISSNSSASILESKSLYDEVAAQGEVVRKLKAEKSPKAKINE
AVECLLSLKAQYKEKTGKEYIPGQPPLSQSSDSSPTRNSEPAGLETPEAKVLFDKVASQG
EVVRKLKTEKAPKDQVDIAVQELLQLKAQYKSLIGVEYKPVSATGAEDKDKKKKEKENKS
EKQNKPQKQNDGQRKDPSKNQGGGLSSSGAGEGQGPKKQTRLGLEAKKEENLADWYSQVI
TKSEMIEYHDISGCYILRPWAYAIWEAIKDFFDAEIKKLGVENCYFPMFVSQSALEKEKT
HVADFAPEVAWVTRSGKTELAEPIAIRPTSETVMYPAYAKWVQSHRDLPIKLNQWCNVVR
WEFKHPQPFLRTREFLWQEGHSAFATMEEAAEEVLQILDLYAQVYEELLAIPVVKGRKTE
KEKFAGGDYTTTIEAFISASGRAIQGGTSHHLGQNFSKMFEIVFEDPKIPGEKQFAYQNS
WGLTTRTIGVMTMVHGDNMGLVLPPRVACVQVVIIPCGITNALSEEDKEALIAKCNDYRR
RLLSVNIRVRADLRDNYSPGWKFNHWELKGVPIRLEVGPRDMKSCQFVAVRRDTGEKLTV
AENEAETKLQAILEDIQVTLFTRASEDLKTHMVVANTMEDFQKILDSGKIVQIPFCGEID
CEDWIKKTTARDQDLEPGAPSMGAKSLCIPFKPLCELQPGAKCVCGKNPAKYYTLFGRSY


# Metabolic_Enzyme_5_Number_of_Residues:
1440

# Metabolic_Enzyme_5_Molecular_Weight:
163028

# Metabolic_Enzyme_5_Theoretical_pI:
7.75

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  proline-tRNA ligase activity
Function:  glutamate-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  prolyl-tRNA aminoacylation
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  glutamyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  protein biosynthesis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_5_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_5_Specific_Function:
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)

# Metabolic_Enzyme_5_Pathway:
map00251  Glutamate metabolism;
 map00860  Porphyrin and chlorophyll metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_5_Reaction:
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF03129:HGTP_anticodon;
PF09180:ProRS-C_1;
PF00749:tRNA-synt_1c;
PF03950:tRNA-synt_1c_C;
PF00587:tRNA-synt_2b;
PF00458:WHEP-TRS

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 6.1.1.17;EC 6.1.1.15

# Metabolic_Enzyme_5_GenBank_ID_Protein:
31958

# Metabolic_Enzyme_5_SwissProt_ID:
SYEP_HUMAN (P07814)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
EPRS

# Metabolic_Enzyme_5_Geneatlas_id:
EPRS

# Metabolic_Enzyme_5_hgnc_id:
HGNC:3418

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Not Available

# Metabolic_Enzyme_5_Gene_Sequence:
>4323 bp
ATGGAACATACTGAGATTGATCACTGGTTGGAGTTCAGTGCTACAAAATTATCTTCATGT
GATTCCTTTACTTCTACAATTAATGAACTCAATCATTGCCTGTCTCTGAGAACATACTTA
GTTGGAAACTCCTTGAGTTTAGCAGATTTATGTGTTTGGGCCACCCTAAAAGGAAATGCT
GCCTGGCAAGAACAGTTGAAACAGAAGAAAGCTCCAGTTCATGTAAAACGTTGGTTTGGC
TTTCTTGAAGCCCAGCAGGCCTTCCAGTCAGTAGGTACCAAGTGGGATGTTTCAACAACC
AAAGCTCGAGTGGCACCTGAGAAAAAGCAAGATGTTGGGAAATTTGTTGAGCTTCCAGGT
GCGGAGATGGGAAAGGTTACCGTCAGATTTCCTCCAGAGGCCAGTGGTTACTTACACATT
GGGCATGCAAAAGCTGCTCTTCTGAACCAGCACTACCAGGTTAACTTTAAAGGGAAACTG
ATCATGAGATTTGATGACACAAATCCTGAAAAAGAAAAGGAAGATTTTGAGAAGGTTATC
TTGGAAGATGTTGCAATGTTGCATATCAAACCAGATCAATTTACTTATACTTCGGATCAT
TTTGAAACTATAATGAAGTATGCAGAGAAGCTAATTCAAGAAGGGAAGGCTTATGTGGAT
GATACTCCTGCTGAACAGATGAAAGCAGAACGTGAGCAGAGGATAGAATCTAAACATAGA
AAAAACCCTATTGAGAAGAATCTACAAATGTGGGAAGAAATGAAAAAAGGGAGCCAGTTT
GGTCACTCCTGTTGTTTGCGAGCAAAAATTGACATGAGTAGTAACAATGGATGCATGAGA
GATCCAACCCTTTATCGCTGCAAAATTCAACCACATCCAAGAACTGGAAATAAATACAAT
GTTTATCCAACATATGATTTTGCCTGCCCCATAGTTGACAGCATCGAAGGTGTTACACAT
GCCCTGAGAACAACAGAATACCATGACAGAGATGAGCAGTTTTACTGGATTATTGAAGCT
TTAGGCATAAGAAAACCATATATTTGGGAATATAGTCGGCTAAATCTCAACAACACAGTG
CTATCCAAAAGAAAACTCACATGGTTTGTCAATGAAGGACTAGTAGATGGATGGGATGAC
CCAAGATTTCCTACGGTTCGTGGTGTACTGAGAAGAGGGATGACAGTTGAAGGACTGAAA
CAGTTTATTGCTGCTCAGGGCTCCTCACGTTCAGTCGTGAACATGGAGTGGGACAAAATC
TGGGCGTTTAACAAAAAGGTTATTGACCCAGTGGCTCCACGATATGTTGCATTACTGAAG
AAAGAAGTGATCCCAGTGAATGTACCTGAAGCTCAGGAGGAGATGAAAGAAGTAGCCAAA
CACCCAAAGAATCCTGAGGTTGGCTTGAAGCCTGTGTGGTATAGTCCCAAAGTTTTCATT
GAAGGTGCTGATGCAGAGACTTTTTCGGAGGGTGAGATGGTTACATTTATAAATTGGGGC
AACCTCAACATTACAAAAATACACAAAAATGCAGATGGAAAAATCATATCTCTTGATGCA
AAGTTTAATTTGGAAAACAAAGACTACAAGAAAACCACTAAGGTCACTTGGCTTGCAGAG
ACTACACATGCTCTTCCTATTCCAGTAATCTGTGTCACTTATGAGCACTTGATCACAAAG
CCAGTGCTAGGAAAAGACGAGGACTTTAAGCAGTATGTCAACAAGAACAGTAAGCATGAA
GAGCTAATGCTAGGGGATCCCTGCCTTAAGGATTTGAAAAAAGGAGATATTATACAACTC
CAGAGAAGAGGATTCTTCATATGTGATCAACCTTATGAACCTGTTAGCCCATATAGTTGC
AAGGAAGCCCCGTGTGTTTTGATATACATTCCTGATGGGCACACAAAGGAAATGCCAACA
TCAGGGTCAAAGGAAAAGACCAAAGTAGAAGCCACAAAAAATGAGACCTCTGCTCCTTTT
AAGGAAAGACCAACACCTTCTCTGAATAATAATTGTACTACATCTGAGGATTCCTTGGTC
CTTTACAATAGAGTGGCTGTTCAAGGAGATGTGGTTCGTGAATTAAAAGCCAAGAAAGCA
CCAAAGGAAGATGTAGATGCAGCTGTAAAACAGCTTTTGTCTTTGAAAGCTGAATATAAG
GAGAAAACTGGCCAGGAATATAAACCTGGAAACCCTCCTGCTGAAATAGGACAGAATATT
TCTTCTAATTCCTCAGCAAGTATTCTGGAAAGTAAATCTCTGTATGATGAAGTTGCTGCA
CAAGGGGAGGTGGTTCGTAAGCTAAAAGCTGAAAAATCCCCTAAGGCTAAAATAAATGAA
GCTGTAGAATGCTTACTGTCCCTGAAGGCTCAGTATAAAGAAAAAACTGGGAAGGAGTAC
ATACCTGGTCAGCCCCCATTATCTCAAAGTTCGGATTCAAGCCCAACCAGAAATTCTGAA
CCTGCTGGTTTAGAAACACCAGAAGCGAAAGTACTTTTTGACAAAGTAGCTTCTCAAGGG
GAAGTAGTTCGGAAACTTAAAACTGAAAAAGCCCCTAAGGATCAAGTAGATATAGCTGTT
CAAGAACTCCTTCAGCTAAAGGCACAGTACAAGTCTTTGATAGGAGTAGAGTATAAGCCT
GTGTCGGCCACTGGAGCTGAGGACAAAGATAAGAAGAAGAAAGAAAAAGAAAATAAATCT
GAAAAGCAGAATAAGCCTCAGAAACAAAATGATGGCCAAAGGAAAGACCCTTCTAAAAAC
CAAGGAGGTGGGCTCTCATCAAGTGGAGCAGGAGAAGGGCAGGGGCCTAAGAAACAGACC
AGGTTGGGTCTTGAGGCAAAAAAAGAAGAAAATCTTGCTGATTGGTATTCTCAGGTCATC
ACAAAGTCAGAAATGATTGAATACCATGACATAAGTGGCTGTTATATTCTTCGTCCCTGG
GCCTATGCCATTTGGGAAGCCATCAAGGACTTTTTTGATGCTGAGATCAAGAAACTTGGT
GTTGAAAACTGCTACTTCCCCATGTTTGTGTCTCAAAGTGCATTAGAGAAAGAGAAGACT
CATGTTGCTGACTTTGCCCCAGAGGTTGCTTGGGTTACAAGATCTGGCAAAACCGAGCTG
GCAGAACCAATTGCCATTCGTCCTACTAGTGAAACAGTAATGTATCCTGCATATGCAAAA
TGGGTACAATCACACAGAGACCTGCCCATCAAGCTCAATCAGTGGTGCAATGTGGTGCGT
TGGGAATTCAAGCATCCTCAGCCTTTCCTACGTACTCGTGAATTTCTTTGGCAGGAAGGG
CACAGTGCTTTTGCTACCATGGAAGAGGCAGCGGAAGAGGTCTTGCAGATACTTGACTTA
TATGCTCAGGTATATGAAGAACTCCTGGCAATTCCTGTTGTTAAAGGAAGAAAGACGGAA
AAGGAAAAATTTGCAGGAGGAGACTATACAACTACAATAGAAGCATTTATATCTGCTAGT
GGAAGAGCTATCCAGGGAGGAACATCACATCATTTAGGGCAGAATTTTTCCAAAATGTTT
GAAATCGTTTTTGAAGATCCAAAGATACCAGGAGAGAAGCAATTTGCCTATCAAAACTCC
TGGGGCCTGACAACTCGAACTATTGGTGTTATGACCATGGTTCATGGGGACAACATGGGT
TTAGTATTACCACCCCGTGTAGCATGTGTTCAGGTGGTGATTATTCCTTGTGGCATTACC
AATGCACTTTCTGAAGAAGACAAAGAAGCGCTGATTGCAAAATGCAATGATTATCGAAGG
CGATTACTCAGTGTTAACATCCGCGTTAGAGCTGATTTACGAGATAATTATTCTCCAGGT
TGGAAATTCAATCACTGGGAGCTCAAGGGAGTTCCCATTAGACTTGAAGTTGGGCCACGT
GATATGAAGAGCTGTCAGTTTGTAGCCGTCAGACGAGATACTGGAGAAAAGCTGACAGTT
GCTGAAAATGAGGCAGAGACTAAACTTCAAGCTATTTTGGAAGACATCCAGGTCACCCTT
TTCACAAGGGCTTCTGAAGACCTTAAGACTCATATGGTTGTGGCTAATACAATGGAAGAC
TTTCAGAAGATACTAGATTCTGGAAAGATTGTTCAGATTCCATTCTGTGGGGAAATTGAC
TGTGAGGACTGGATCAAAAAGACCACTGCCAGGGATCAAGATCTTGAACCTGGTGCTCCA
TCCATGGGAGCTAAAAGCCTTTGCATCCCCTTCAAACCACTCTGTGAACTGCAGCCTGGA
GCCAAATGTGTCTGTGGCAAGAACCCTGCCAAGTACTACACCTTATTTGGTCGCAGCTAC
TGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X54326

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_5_Locus:
1q41-q42

# Metabolic_Enzyme_5_SNPs:
rs5030752; rs2230301; rs35999099; rs34559775; rs5030751; rs1061160; rs5030754; rs36122746; rs1061242; rs1061248; rs6695781; rs2577138; rs1768672; rs2647468; rs1694601; rs2647447; rs2577144; rs2647459; rs2133194; rs2577150; rs1498393; rs2789797; rs2795314; rs2291838; rs2647435; rs2173403; rs2577145; rs1694576; rs2647462; rs2133195; rs2647469; rs1768673; rs2577137; rs1624678; rs2270710; rs2795310; rs2789816; rs2577136; rs2577159; rs7535767; rs1391566; rs10779396; rs7550249; rs1611961; rs7553236; rs2577149; rs2647430; rs6541124; rs10495143; rs3820457; rs3767671; rs6697041; rs6686451; rs1630386; rs2270711; rs10746395; rs1982985; rs7535773; rs12080607; rs6699641; rs6669906; rs1982986; rs2647470; rs2248479; rs2577148; rs2789798; rs4846612; rs2577146; rs2270712; rs1694577; rs2577140; rs2647445; rs2647461; rs2789793; rs10779393; rs6541120; rs1874811; rs2789794; rs2647464; rs7535650; rs2647463; rs6690630; rs3816993; rs2254494; rs2647457; rs2789817; rs2647454; rs2789796; rs11806631; rs2647420; rs2647428; rs2253521; rs2647458; rs2577141; rs1658227; rs2248466; rs2577158; rs6681471; rs2647436; rs2577156; rs2270709; rs7536968; rs2577163; rs10779395; rs11118485; rs3767661; rs4846611; rs2647479; rs11118490; rs7521682; rs6660598; rs2291836; rs2647429; rs3767670; rs1694599; rs2789809; rs6681055; rs1658226; rs2789813; rs12057663; rs10779394; rs10442684; rs12079635; rs2789810; rs11118488; rs10746396; rs2647453; rs10779391; rs7548397; rs2647467; rs3767669; rs2577142; rs10863524; rs10863528; rs11118486; rs10863523; rs7524619; rs7527659; rs1768665; rs10863521; rs7517173; rs4531301; rs2454326; rs12084571; rs3767675; rs1982987; rs7521388; rs2647478; rs7539385; rs6672134; rs17007062; rs10863527; rs4846610; rs6683340; rs7537559; rs7527749; rs12126940; rs12142009; rs2577147; rs2789799; rs4536003; rs949866; rs2789812; rs12022181; rs2789802; rs6703042; rs1768675; rs2647446; rs10863525; rs17007011; rs2248717; rs1612144; rs12032898; rs1557130; rs1846254; rs12032866; rs10442692; rs17006978; rs12123041; rs10863522; rs2647444; rs2647460; rs1694600; rs1768677; rs3767668; rs7537058; rs11118487; rs11118480; rs1768668; rs1622508; rs12073836; rs3767657; rs6674466; rs2647425; rs1566252; rs3820456; rs1768671; rs2789811; rs11118489; rs1768670; rs2647433; rs1768666; rs1498394; rs1874813; rs2486328; rs1874810; rs2577151; rs4379680; rs12069364; rs12726890; rs2248719; rs2577143; rs10863526; rs6692978; rs1982984; rs2245457; rs6681474; rs1694575; rs12048112; rs2577160; rs2789795; rs12140664; rs7545314; rs11811749; rs7531703; rs2577139; rs2647431; rs2789815; rs2647432; rs11118483; rs6690280; rs1874812; rs2577165; rs3767663; rs1768669; rs1874814; rs9988498; rs12117454; rs1846255; rs3767658; rs2647438; rs17007084; rs2647474; rs1768676; rs2647448; rs7534891; rs17006931; rs2577161; rs3816994; rs2027504; rs2030078; rs2030079; rs11118477; rs5030753; rs1063236; rs35325299; rs35055527; rs12144752; rs35578666; rs10987; rs41274786; rs2270713; rs2789804; rs5781162; rs12097519; rs11322745; rs28758924; rs10543617; rs35970586; rs2647424; rs35064558; rs35228542; rs34101093; rs12737399; rs35193743; rs12128043; rs12141517; rs3215088; rs1768667; rs35845125; rs12080935; rs35917562; rs2577164; rs5781163; rs12068478; rs7545874; rs6669531; rs35942761; rs36078678; rs1768674; rs12126592; rs12754826; rs6677609; rs2647423; rs35420771; rs12098052; rs34415535; rs2291837; rs10582505; rs2647434; rs2577157; rs12057468; rs10551734; rs2789806; rs12091960; rs35440326; rs33962064; rs34070653; rs2789800; rs3835619; rs34052861; rs35525846; rs34510927; rs35952109; rs3830400; rs1614719; rs10698600; rs7544184; rs35962858; rs953756; rs12031429; rs6670629; rs12080610; rs28609698; rs3830399; rs33914465; rs2647449; rs34314894; rs12090303; rs10570178; rs36181278; rs35341641; rs12736674; rs7414048; rs2647450; rs10569658; rs2789819; rs35995726; rs35247222; rs7548301; rs12084196; rs12059479; rs34224725; rs35329556; rs2647437; rs3767673; rs2647475; rs35539406; rs11414713; rs11340220; rs11323724; rs10547980; rs11118482; rs3767667; rs12060231; rs35015102; rs35656997; rs2647452; rs12145391; rs35659781; rs11808639; rs12097441; rs12141971; rs10157133; rs7525311; rs10612871; rs12071984; rs35469644; rs34084629; rs2789808; rs34084372; rs12238988; rs12059527; rs12754990; rs2647427; rs34218503; rs9786983; rs10645019; rs12747650; rs2789807; rs11284910; rs35194885; rs34320023; rs12062082; rs11325774; rs10697205; rs10638364; rs2789805; rs10697206; rs35018508; rs10465680; rs35938749; rs10554810; rs5781161; rs12090804; rs11118478; rs6680671; rs34316201; rs35787330; rs2795315; rs41304103; rs10656420; rs34626963; rs1614384; rs12071410; rs12059273; rs11291617; rs35145633; rs2647451; rs2647456; rs34170326; rs12040930; rs2647422; rs36089275; rs34459588; rs35449773; rs35391458; rs12045445; rs7539406; rs1542840; rs34090474; rs1614585; rs41274788; rs2011624; rs12095669; rs34544630; rs6702241; rs2647421; rs28612895; rs7524382; rs10442691; rs12081205; rs34917248; rs2133196; rs10551735; rs34309222; rs35204038; rs3835618; rs6667964; rs35446521; rs35241194; rs41304101; rs17007032; rs11278281; rs2647426; rs10595099; rs11382775; rs12049352; rs35440314; rs10570179; rs12058150; rs3055587; rs34026037; rs34537346; rs34343274; rs12076227; rs12046562; rs34094913; rs3835617; rs34000580; rs34321649; rs35060859; rs35108914; rs2647455; rs1909199; rs3916109; rs36065087; rs28570471; rs12072662; rs11286771; rs11118481; rs2789803; rs2577162; rs11317813; rs5781164; rs35421250; rs10157645; rs5781160; rs35984976; rs11355174; rs35879695; rs35533895; rs10611128; rs11590370; rs10779390; rs11118476; rs12734813; rs2789784; rs4846608; rs6663868; rs6663947; rs7516830; rs7549576

# Metabolic_Enzyme_5_General_References:
1988429; 3290852; 1756734; 1556743; 11123902

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5539

# Metabolic_Enzyme_6_Name:
Prolyl 4-hydroxylase subunit alpha-1 precursor

# Metabolic_Enzyme_6_Synonyms:
4-PH alpha-1; Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-1 subunit

# Metabolic_Enzyme_6_Gene_Name:
P4HA1

# Metabolic_Enzyme_6_Protein_Sequence:
>Prolyl 4hydroxylase subunit alpha1 precursor
MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA
EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY
FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY
YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR
ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKM
TPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRL
RRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANY
GVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG
TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE

# Metabolic_Enzyme_6_Number_of_Residues:
534

# Metabolic_Enzyme_6_Molecular_Weight:
61050

# Metabolic_Enzyme_6_Theoretical_pI:
5.84

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Catalyzes the posttranslational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins

# Metabolic_Enzyme_6_Pathway:
map00330  Arginine and proline metabolism

# Metabolic_Enzyme_6_Reaction:
procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF03171:2OG-FeII_Oxy;
PF08336:P4Ha_N;
PF07719:TPR_2

# Metabolic_Enzyme_6_Signals:
1-17

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.14.11.2

# Metabolic_Enzyme_6_GenBank_ID_Protein:
190786

# Metabolic_Enzyme_6_SwissProt_ID:
P4HA1_HUMAN (P13674)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
P4HA1

# Metabolic_Enzyme_6_Geneatlas_id:
P4HA1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:8546

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum lumen

# Metabolic_Enzyme_6_Gene_Sequence:
>1605 bp
ATGATCTGGTATATATTAATTATAGGAATTCTGCTTCCCCAGTCTTTGGCTCATCCAGGC
TTTTTTACTTCAATTGGTCAGATGACTGATTTGATCCATACTGAGAAAGATCTGGTGACT
TCTCTGAAAGATTATATTAAGGCAGAAGAGGACAAGTTAGAACAAATAAAAAAATGGGCA
GAGAAGTTAGATCGGCTAACTAGTACAGCGACAAAAGATCCAGAAGGATTTGTTGGGCAT
CCAGTAAATGCATTCAAATTAATGAAACGTCTGAATACTGAGTGGAGTGAGTTGGAGAAT
CTGGTCCTTAAGGATATGTCAGATGGCTTTATCTCTAACCTAACCATTCAGAGACCAGTA
CTTTCTAATGATGAAGATCAGGTTGGGGCAGCCAAAGCTCTGTTACGTCTCCAGGATACC
TACAATTTGGATACAGATACCATCTCAAAGGGTAATCTTCCAGGAGTGAAACACAAATCT
TTTCTAACGGCTGAGGACTGCTTTGAGTTGGGCAAAGTGGCCTATACAGAAGCAGATTAT
TACCATACGGAACTGTGGATGGAACAAGCCCTAAGGCAACTGGATGAAGGCGAGATTTCT
ACCATAGATAAAGTCTCTGTTCTAGATTATTTGAGCTATGCGGTATATCAGCAGGGAGAC
CTGGATAAGGCACTTTTGCTCACAAAGAAGCTTCTTGAACTAGATCCTGAACATCAGAGA
GCTAATGGTAACTTAAAATATTTTGAGTATATAATGGCTAAAGAAAAAGATGTCAATAAG
TCTGCTTCAGATGACCAATCTGATCAGAAAACTACACCAAAGAAAAAAGGGGTTGCTGTG
GATTACCTGCCAGAGAGACAGAAGTACGAAATGCTGTGCCGTGGGGAGGGTATCAAAATG
ACCCCTCGGAGACAGAAAAAACTCTTTTGCCGCTACCATGATGGAAACCGTAATCCTAAA
TTTATTCTGGCTCCAGCTAAACAGGAGGATGAATGGGACAAGCCTCGTATTATTCGCTTC
CATGATATTATTTCTGATGCAGAAATTGAAATCGTCAAAGACCTAGCAAAACCAAGGCTG
AGCCGAGCTACAGTACATGACCCTGAGACTGGAAAATTGACCACAGCACAGTACAGAGTA
TCTAAGAGTGCCTGGCTCTCTGGCTATGAAAATCCTGTGGTGTCTCGAATTAATATGAGA
ATACAAGATCTAACAGGACTAGATGTTTCCACAGCAGAGGAATTACAGGTAGCAAATTAT
GGAGTTGGAGGACAGTATGAACCCCATTTTGACTTTGCACGGAAAGATGAGCCAGATGCT
TTCAAAGAGCTGGGGACAGGAAATAGAATTGCTACATGGCTGTTTTATATGAGTGATGTG
TCTGCAGGAGGAGCCACTGTTTTTCCTGAAGTTGGAGCTAGTGTTTGGCCCAAAAAAGGA
ACTGCTGTTTTCTGGTATAATCTGTTTGCCAGTGGAGAAGGAGATTATAGTACACGGCAT
GCAGCCTGTCCAGTGCTAGTTGGCAACAAATGGGTATCCAATAAATGGCTCCATGAACGT
GGACAAGAATTTCGAAGACCTTGTACGTTGTCAGAATTGGAATGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M24486

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_6_Locus:
10q21.3-q23.1

# Metabolic_Enzyme_6_SNPs:
rs7920974; rs7078127; rs6480667; rs12570974; rs6480668; rs10823977; rs7905836; rs11000516; rs12242222; rs12260669; rs11000517; rs12242214; rs12571459; rs12573499; rs7095810; rs4405231; rs6480666; rs7095904; rs7088078; rs2394928; rs7072019; rs11000515; rs7915269; rs12217855; rs9787672; rs28384495; rs12261293; rs2394919; rs11597837; rs7077346; rs7077281; rs12766755; rs12573512; rs6480653; rs3736278; rs7094342; rs7072071; rs7904719; rs7076642; rs6480655; rs7085141; rs10823975; rs6480654; rs12253630; rs6480661; rs12244027; rs7908682; rs10762535; rs6480660; rs4572061; rs11000491; rs6480659; rs4387274; rs6480663; rs7078818; rs6480662; rs12253317; rs12261668; rs4366408; rs12255146; rs12249050; rs11000506; rs12248308; rs12262696; rs9663510; rs2394920; rs12260461; rs12253518; rs4469800; rs11000510; rs12244049; rs7095061; rs6480664; rs6480658; rs7911861; rs12247364; rs10458655; rs12249126; rs7912848; rs11000499; rs10823976; rs12241143; rs7903684; rs11000511; rs9787516; rs6480665; rs12258500; rs12243988; rs7898822; rs16930271; rs12769591; rs12249431; rs12243451; rs12571941; rs7918396; rs7901481; rs1140462; rs1130885; rs1130886; rs34567673; rs34312165; rs1130890; rs1130887; rs34845894; rs1130884; rs11000512; rs11559264; rs1130889; rs35382319; rs2894191; rs28679854; rs34584160; rs34990120; rs11334323; rs12764491; rs12264323; rs28548263; rs34903468; rs7913148; rs34088796; rs12259071; rs35281975; rs12778451; rs11000520; rs34996723; rs34701143; rs35214128; rs12253350; rs12777708; rs11000514; rs10823980; rs34645636; rs10691278; rs10674198; rs11000513; rs11340358; rs3065972; rs35159575; rs7072016; rs7076700; rs10700344; rs2894192; rs11336622; rs11000519; rs12764311; rs5786098; rs36056230; rs1804257; rs12764504; rs12780338; rs35811135; rs10561551; rs36105566; rs35838791; rs12572256; rs35462247; rs10674781; rs11400869; rs11000497; rs28692884; rs11599563; rs10649250; rs4745712; rs12416008; rs35466966; rs12164712; rs17658374; rs12769358; rs11000505; rs11393613; rs34854861; rs12262881; rs34399366; rs11000508; rs34610783; rs11389497; rs3830350; rs12771344; rs35884198; rs35112393; rs11275675; rs11814343; rs3998391; rs7896744; rs12248714; rs7913609; rs34379137; rs12255388; rs11000500; rs12262986; rs11000504; rs12246277; rs34457485; rs11527421; rs35176849; rs3065978; rs12416021; rs35875050; rs10603432; rs12258140; rs2894193; rs11498022; rs11000503; rs12258753; rs35527169; rs12240932; rs41307520; rs34420722; rs9663290; rs35435004; rs36107511; rs12570010; rs11000493; rs12411647; rs28853423; rs2394929; rs35190522; rs12246228; rs5786097; rs10539580; rs35067388; rs7921747; rs7902639; rs10584360; rs11000502; rs34461487; rs35914404; rs36080367; rs12251674; rs12253449; rs11498023; rs11398474; rs2394921; rs7908892; rs41315002; rs9732032; rs12262714; rs35537940; rs11000494; rs41307512; rs12248134; rs35484631; rs9787606; rs4745711; rs35199506; rs12243819; rs34565865; rs7095773; rs10634037; rs10661785; rs11497795; rs7912619; rs34677025; rs12263220; rs10698728; rs11000486; rs11000487; rs11000488; rs11000489; rs11000490; rs11813121; rs12573768; rs16930262; rs2394924; rs2394925; rs2394926; rs34162681; rs35323750; rs3998396; rs4258298; rs4522088; rs4529828; rs7071334; rs7076718; rs7077056; rs7078081; rs7082363; rs7094115; rs7894359; rs7896197; rs7897191; rs7906123; rs7907485; rs7922533

# Metabolic_Enzyme_6_General_References:
2543975; 7961714

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
8489

# Metabolic_Enzyme_7_Name:
Pyrroline-5-carboxylate reductase-like variant

# Metabolic_Enzyme_7_Synonyms:
Not Available

# Metabolic_Enzyme_7_Gene_Name:
PYCRL

# Metabolic_Enzyme_7_Protein_Sequence:
>Pyrroline5carboxylate reductaselike variant
MGGERSGVRGNKMAAAEPSPRRVGFVGAGRMAGAIAQGLIRAGKVEAQHILASAPTDRNL
CHFQALGCRTTHSNQEVLQSCLLVIFATKPHVLPAVLAEVAPVVTTEHILVSVAAGVSLS
TLEELLPPNTRVLRVLPNLPCVVQEGAIVMARGRHVGSSETNLLQHLLEACGRCEEVPEA
YVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPA
QLRSDVCTPGGTTIYGLHALALVWIQAPSFLPILSS

# Metabolic_Enzyme_7_Number_of_Residues:
276

# Metabolic_Enzyme_7_Molecular_Weight:
28886

# Metabolic_Enzyme_7_Theoretical_pI:
7.57

# Metabolic_Enzyme_7_GO_Classification:
>>>
 Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
Function:  pyrroline-5-carboxylate reductase activity
 ||
>>>
 Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  proline metabolism
Process:  proline biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Amino acid transport and metabolism

# Metabolic_Enzyme_7_Specific_Function:
Not Available

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
Not Available

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF03807:F420_oxidored

# Metabolic_Enzyme_7_Signals:
Not Available

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.5.1.2

# Metabolic_Enzyme_7_GenBank_ID_Protein:
62896929

# Metabolic_Enzyme_7_SwissProt_ID:
Q53H96_HUMAN (Q53H96)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
PYCRL

# Metabolic_Enzyme_7_Geneatlas_id:
PYCRL

# Metabolic_Enzyme_7_hgnc_id:
HGNC:25846

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>831 bp
ATGGGCGGTGAGCGCAGCGGCGTCCGAGGCAACAAGATGGCAGCTGCGGAGCCGTCTCCG
CGGCGCGTGGGCTTCGTGGGCGCGGGCCGCATGGCGGGGGCCATCGCGCAGGGCCTCATC
AGAGCAGGAAAAGTGGAAGCTCAGCACATACTGGCCAGTGCACCAACAGACAGGAACCTA
TGTCACTTTCAAGCTCTGGGTTGCCGGACCACGCACTCCAACCAGGAGGTGCTGCAGAGC
TGCCTGCTCGTCATCTTTGCCACCAAGCCTCATGTGCTGCCAGCTGTCCTGGCAGAGGTG
GCTCCTGTGGTCACCACTGAACACATCTTGGTGTCCGTGGCTGCTGGGGTGTCTCTGAGC
ACCCTGGAGGAGCTGCTGCCCCCAAACACACGGGTGCTGCGGGTCTTGCCCAACCTGCCC
TGTGTGGTCCAGGAAGGGGCCATAGTGATGGCGCGGGGCCGCCACGTGGGGAGCAGCGAG
ACCAACCTCCTGCAGCATCTGCTGGAGGCCTGTGGGCGGTGTGAGGAGGTGCCTGAAGCC
TACGTCGACATCCACACTGGCCTCAGTGGCAGTGGCGTGGCCTTCGTGTGTGCATTCTCC
GAGGCCCTGGCTGAAGGAGCCGTCAAGATGGGCATGCCCAGCAGCCTGGCCCACCGCATC
GCTGCCCAGACCCTGCTGGGGACGGCCAAGATGCTGCTGCACGAGGGCCAACACCCAGCC
CAGCTGCGCTCAGACGTGTGCACCCCGGGTGGCACCACCATCTATGGACTCCACGCCCTG
GCTTTAGTCTGGATACAGGCTCCCTCTTTCCTCCCAATCCTAAGCTCCTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AK222685

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_7_Locus:
8q24.3

# Metabolic_Enzyme_7_SNPs:
rs2242090; rs11549789; rs2242089; rs35955574; rs896962; rs896961; rs4559251; rs755217; rs2242088; rs4874169; rs2278898; rs11786955; rs10097337; rs4874170; rs11136305; rs3812442; rs3812445; rs4403422; rs2085014; rs4874168; rs4874171; rs2278897; rs3816477; rs4874167; rs3812443; rs7460585; rs1076981; rs4242490; rs2085016; rs3812444; rs35552090; rs34121654; rs35729228; rs3841186; rs11774317; rs28405113; rs34892354; rs34360518; rs35243993; rs35786252; rs7818082; rs35156525; rs4874172; rs5895780; rs28688294; rs11403801; rs2085015; rs3058417; rs35760562; rs34979030; rs35646830; rs13271996; rs35196198; rs28497517; rs2085017; rs35283039; rs4289832; rs34637455; rs2005166; rs10112966; rs10282929; rs1049832; rs1049876; rs1049886; rs10866913; rs11987209; rs12681580; rs1563153; rs2045084; rs2242085; rs2242086; rs2242095; rs2978; rs33966099; rs3812446; rs4634659; rs4873808; rs4873809; rs4874165; rs6995499; rs7000400; rs7817301; rs7844633; rs7844940

# Metabolic_Enzyme_7_General_References:
8125298; 9373149

# Metabolic_Enzyme_7_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8518

# Macromolecular_Interacting_Partner_1_Name:
Proton-coupled amino acid transporter 1

# Macromolecular_Interacting_Partner_1_Synonyms:
Proton/amino acid transporter 1; Solute carrier family 36 member 1

# Macromolecular_Interacting_Partner_1_Gene_Name:
SLC36A1

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Protoncoupled amino acid transporter 1
MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNSTTWFQTLIHLLKGN
IGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCAHHFCRRLNKSFVDYGDTV
MYGLESSPCSWLRNHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQVIEAANGTTNNC
HNNETVILTPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIV
QRIPDPSHLPLVAPWKTYPLFFGTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVT
ILYISLGCLGYLQFGANIQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIP
FFVSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLE
VTTFYSEGMSPLTIFKDALISILGFVGFVVGTYEALYELIQPSNAPIFINSTCAFI

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
476

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
53076

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.00

# Macromolecular_Interacting_Partner_1_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_1_Specific_Function:
Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_1_Signals:
1-216

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
52-72
79-99
142-162
191-211
216-236
258-278
290-310
343-363
373-393
398-418
440-460

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
31324239

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
S36A1_HUMAN (Q7Z2H8)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
SLC36A1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
SLC36A1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:18761

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cell membrane; multi-pass membrane protein. Lysosome; lysosomal membrane; multi-pass membrane protein (By similarity)

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1431 bp
ATGTCCACGCAGAGACTTCGGAATGAAGACTACCACGACTACAGCTCCACGGACGTGAGC
CCTGAGGAGAGCCCGTCGGAAGGCCTCAACAACCTCTCCTCCCCGGGCTCCTACCAGCGC
TTTGGTCAAAGCAATAGCACAACATGGTTCCAGACCTTGATCCACCTGTTAAAAGGCAAC
ATTGGCACAGGACTCCTGGGACTCCCTCTGGCGGTGAAAAATGCAGGCATCGTGATGGGT
CCCATCAGCCTGCTGATCATAGGCATCGTGGCCGTGCACTGCATGGGTATCCTGGTGAAA
TGTGCTCACCACTTCTGCCGCAGGCTGAATAAATCCTTTGTGGATTATGGTGATACTGTG
ATGTATGGACTAGAATCCAGCCCCTGCTCCTGGCTCCGGAACCACGCACACTGGGGAAGA
CGTGTTGTGGACTTCTTCCTGATTGTCACCCAGCTGGGATTCTGCTGTGTCTATTTTGTG
TTTCTGGCTGACAACTTTAAACAGGTGATAGAAGCGGCCAATGGGACCACCAATAACTGC
CACAACAATGAGACGGTGATTCTGACGCCTACCATGGACTCGCGACTCTACATGCTCTCC
TTCCTGCCCTTCCTGGTGCTGCTGGTTTTCATCAGGAACCTCCGAGCCCTGTCCATCTTC
TCCCTGTTGGCCAACATCACCATGCTGGTCAGCTTGGTCATGATCTACCAGTTCATTGTT
CAGAGGATCCCAGACCCCAGCCACCTCCCCTTGGTGGCCCCTTGGAAGACCTACCCTCTC
TTCTTTGGCACAGCGATTTTTTCATTTGAAGGCATTGGAATGGTTCTGCCCCTGGAAAAC
AAAATGAAGGATCCTCGGAAGTTCCCACTCATCCTGTACCTGGGCATGGTCATCGTCACC
ATCCTCTACATCAGCCTGGGGTGTCTGGGGTACCTGCAATTTGGAGCTAATATCCAAGGC
AGCATAACCCTCAACCTGCCCAACTGCTGGTTGTACCAGTCAGTTAAGCTGCTGTACTCC
ATCGGGATCTTTTTCACCTACGCACTCCAGTTCTACGTCCCGGCTGAGATCATCATCCCC
TTCTTTGTGTCCCGAGCGCCCGAGCACTGTGAGTTAGTGGTGGACCTGTTTGTGCGCACA
GTGCTGGTCTGCCTGACATGCATCTTGGCCATCCTCATCCTCCGCCTGGACCTGGTCATC
TCCCTGGTGGGCTCCGTGAGCAGCAGCGCCCTGGCCCTCATCATCCCACCGCTCCTGGAG
GTCACCACCTTCTACTCAGAGGGCATGAGCCCCCTCACCATCTTTAAGGACGCCCTGATC
AGCATCCTGGGCTTCGGGGGCTTTGGGGGGGGGACCTATGAGGCTCTCTATGAGCTGATC
CAGCCAAGCAATGCTCCCATCTTCATCAATTCCACCTGTGCCTTCATATAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AF516142

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_1_Locus:
5q33.1

# Macromolecular_Interacting_Partner_1_SNPs:
rs9687945; rs918421; rs6871593; rs12655145; rs7706041; rs723329; rs165370; rs6875844; rs729057; rs4958272; rs4958458; rs1175; rs7730595; rs17112008; rs165323; rs165369; rs6872051; rs17740674; rs11954054; rs10077304; rs14160; rs17802828; rs17717168; rs12654623; rs2278372; rs6868032; rs2278373; rs35060330; rs13362472; rs11950575; rs10074670; rs165353; rs165366; rs357620; rs165364; rs357616; rs2271215; rs152722; rs415426; rs165359; rs357618; rs165350; rs357619; rs165363; rs357628; rs357610; rs165352; rs165367; rs357617; rs7700762; rs165351; rs6892322; rs357627; rs165355; rs7729973; rs357624; rs6579877; rs357614; rs152392; rs7730542; rs357629; rs165365; rs357623; rs357611; rs357613; rs152391; rs357622; rs165357; rs7721225; rs11949709; rs357625; rs17112022; rs7715996; rs173349; rs357608; rs2271217; rs152390; rs152389; rs165358; rs165356; rs6891599; rs441652; rs13165298; rs165361; rs165354; rs7722725; rs151755; rs12109083; rs12108809; rs10476986; rs17112026; rs12652584; rs193299; rs12517705; rs17740853; rs181548; rs357621; rs2278374; rs357609; rs13177627; rs394736; rs165360; rs357630; rs357612; rs189615; rs6884262; rs165324; rs10067717; rs3905908; rs10060512; rs35204299; rs34807130; rs36112231; rs34668619; rs34075182; rs34478431; rs165368; rs35191954; rs1238148; rs3832373; rs34023473; rs1876621; rs33959674; rs6865892; rs35523611; rs13436718; rs10054849; rs1494538; rs36036885; rs10635760; rs10076469; rs35240570; rs35074529; rs33931867; rs5872207; rs35097474; rs7710891; rs11553685; rs34867392; rs400501; rs34306317; rs1494537; rs6868168; rs1644031; rs11435061; rs35256722; rs34814099; rs13155218; rs190360; rs34768974; rs34046389; rs34232698; rs35595732; rs10050844; rs6878589; rs28703169; rs35929969; rs11389317; rs35868592; rs13172953; rs11453209; rs35002039; rs165362; rs28625753; rs6860029; rs13355111; rs34928684; rs35727313; rs34320512; rs36220874; rs5872208; rs1047371; rs33918956; rs357626; rs10067276; rs11750448; rs1654089; rs6878344; rs3841626; rs36024368; rs34013133; rs28591205; rs11949963; rs11167548; rs35707638; rs35655674; rs11303709; rs34145742; rs35361647; rs33938062; rs187180; rs7729206; rs11427460; rs10067553; rs6869796; rs34114557; rs13164973; rs3830456; rs34920684; rs35854261; rs11281205; rs2271216; rs33974809; rs3086279; rs34249564; rs10648851; rs12332278; rs35901406; rs35132795; rs36039116; rs28400419; rs34757222; rs34517564; rs35461038; rs10637454; rs11279332; rs2278375; rs35783925; rs13359993; rs34965236; rs6875491; rs35220703; rs35474478; rs13357451; rs34688075; rs6860591; rs12109979; rs36232311; rs11459545; rs35330119; rs10042192; rs10664114; rs10709981; rs11959634; rs28557209; rs10079386; rs6877865; rs35791981; rs10040628; rs10042791; rs10043854; rs10054626; rs10075373; rs10476771; rs11951808; rs11956563; rs13180182; rs165325; rs165326; rs165327; rs165328; rs165329; rs165330; rs165331; rs165332; rs165333; rs165334; rs165335; rs1654090; rs17111998; rs17717506; rs17802804; rs1876620; rs2545666; rs34831908; rs357607; rs385255; rs393824; rs420486; rs4958457; rs6579878; rs6879238; rs6885230; rs7356707; rs7714380; rs9324696

# Macromolecular_Interacting_Partner_1_General_References:
12809675

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8543

# Macromolecular_Interacting_Partner_2_Name:
P53 induced protein

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>P53 induced protein
GAYLAQERARAQIGYEDPINPTYEATNAMYHRCLDYVLEELKHNAKAKVMVASHNEDTVR
FALRRMEELGLHPADHQVYFGQLLGMCDQISFPLGHGWLPRVQVRALWPRDGGAALLVPA
VPWKNSSLMKGTHSGAALAVAGALEAAPNWQPLPSPCLAPASTPSSLPAPPAPCSRPFNQ
QAASQTPILQHRFTFFHPTTLQSLLGGEVRCLPALAQSMGTQVWAEPDTCLGQPLETFGN
SPLKCVGPRPPPL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
253

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
27454

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
7.53

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  proline dehydrogenase activity
 ||
>>>
 Process:  proline metabolism
Process:  proline catabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamate metabolism
Process:  glutamate biosynthesis
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF01619:Pro_dh

# Macromolecular_Interacting_Partner_2_Signals:
Not Available

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
2415297

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
O14680_HUMAN (O14680)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
PRODH

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
PRODH

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:9453

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>762 bp
GGCGCATACCTGGCCCAGGAGCGAGCCCGTGCGCAGATCGGCTATGAGGACCCCATCAAC
CCCACGTACGAGGCCACCAACGCCATGTACCACAGGTGCCTGGACTACGTGTTGGAGGAG
CTGAAGCACAACGCCAAGGCCAAGGTGATGGTGGCCTCCCACAATGAGGACACAGTGCGC
TTCGCACTGCGCAGGATGGAGGAGCTGGGCCTGCATCCTGCTGACCACCAGGTGTACTTT
GGACAGCTGCTAGGCATGTGTGACCAGATCAGCTTCCCGCTGGGCCACGGCTGGCTACCC
CGTGTACAAGTACGTGCCCTATGGCCCCGTGATGGAGGTGCTGCCCTACTTGTCCCCGCC
GTGCCCTGGAAGAACAGCAGCCTCATGAAGGGCACCCATTCGGGAGCGGCACTGGCTGTG
GCTGGAGCTCTTGAAGCGGCTCCGAACTGGCAACCTCTTCCATCGCCCTGCCTAGCACCC
GCCAGCACACCCTCTAGCCTTCCAGCACCCCCCGCCCCCTGCTCCAGGCCATTCAACCAA
CAAGCTGCAAGCCAAACCCCAATCCTTCAACACAGATTCACCTTTTTTCACCCCACCACT
TTGCAGAGCTTGCTTGGAGGTGAGGTCAGGTGCCTCCCAGCCCTTGCCCAGAGTATGGGC
ACTCAGGTGTGGGCCGAACCTGATACCTGCCTGGGACAGCCACTGGAAACTTTTGGGAAC
TCTCCTCTGAAATGTGTGGGCCCAAGGCCCCCACCTCTGTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AF010310

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Locus:
Not Available

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
9305847

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8594

# Macromolecular_Interacting_Partner_3_Name:
SLC38A2 protein

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC38A2

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>SLC38A2 protein
MKQNLILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIG
AMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGY
TSGLSLLCMVFFLIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDS
CRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYL
LAALFGYLTFYEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTH
LLCASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIK
LVKKEPMKSVQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
406

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
45180

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
8.88

# Macromolecular_Interacting_Partner_3_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_3_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_3_Signals:
1-18

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
5-23; 48-69; 89-111; 115-137; 230-252; 272-294; 315-334; 339-361; 373-395

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
Q6IA88_HUMAN (Q6IA88)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC38A2

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC38A2

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:13448

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
CR457267

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_3_Locus:
12q

# Macromolecular_Interacting_Partner_3_SNPs:
rs10880961; rs7968283; rs956910; rs2897968; rs7968173; rs7961994; rs10880959; rs2307063; rs1873793; rs3742061; rs2307061; rs10880960; rs3782904; rs7965930; rs2307062; rs2279559; rs7974529; rs7960147; rs10785624; rs11183450; rs34139863; rs36065261; rs36022751; rs11340856; rs7966787; rs11313787; rs5797976; rs1046296; rs11183449; rs12307969; rs2307060; rs36019260; rs3837525; rs35534621; rs11183447; rs3832874; rs3830356; rs34489723; rs36066221; rs11298796; rs7295472; rs35732850; rs35944767; rs34099989; rs10880962; rs11183446; rs12368989; rs1492896; rs17096884; rs4768697; rs4768698; rs7135630; rs7967840; rs7975820; rs7979418

# Macromolecular_Interacting_Partner_3_General_References:
Not Available

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8673

# Macromolecular_Interacting_Partner_4_Name:
Sodium-coupled neutral amino acid transporter 4

# Macromolecular_Interacting_Partner_4_Synonyms:
Na(+-coupled neutral amino acid transporter 4; Amino acid transporter A3; System A amino acid transporter 3; System N amino acid transporter 3; Solute carrier family 38 member 4

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC38A4

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Sodiumcoupled neutral amino acid transporter 4
MDPMELRNVNIEPDDESSSGESAPDSYIGIGNSEKAAMSSQFANEDTESQKFLTNGFLGK
KKLADYADEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSL
YSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEV
IRAFMGLEENTGEWYLNGNYLIIFVSVGIILPLSLLKNLGYLGYTSGFSLTCMVFFVSVV
IYKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLPNNSESSDVNFMMDYTHRNPAGLDEN
QAKGSLHDSGVEYEAHSDDKCEPKYFVFNSRTAYAIPILVFAFVCHPEVLPIYSELKDRS
RRKMQTVSNISITGMLVMYLLAALFGYLTFYGEVEDELLHAYSKVYTLDIPLLMVRLAVL
VAVTLTVPIVLFPIRTSVITLLFPKRPFSWIRHFLIAAVLIALNNVLVILVPTIKYIFGF
IGASSATMLIFILPAVFYLKLVKKETFRSPQKVGALIFLVVGIFFMIGSMALIIIDWIYD
PPNSKHH

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
547

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
60765

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.45

# Macromolecular_Interacting_Partner_4_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_4_Specific_Function:
Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_4_Signals:
1-531

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
81-101
105-125
152-172
196-216
221-241
333-353
370-390
412-432
454-474
477-497
515-535

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
13876616

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
S38A4_HUMAN (Q969I6)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC38A4

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC38A4

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:14679

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cell membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1644 bp
ATGGATCCCATGGAACTGAGAAATGTCAACATCGAACCAGATGATGAGAGCAGCAGTGGA
GAAAGTGCTCCAGATAGCTACATCGGGATAGGAAATTCAGAAAAGGCAGCAATGAGCAGT
CAATTTGCTAATGAAGACACTGAAAGTCAGAAATTCCTGACAAATGGATTTTTGGGGAAA
AAGAAGCTGGCAGATTATGCTGATGAACACCATCCCGGAACCACTTCCTTTGGAATGTCT
TCATTTAACCTGAGTAATGCCATCATGGGCAGTGGGATCCTGGGCTTGTCCTATGCCATG
GCCAACACAGGGATCATACTTTTTATAATCATGCTGCTTGCTGTGGCAATATTATCACTG
TATTCAGTTCACCTTTTATTAAAAACAGCCAAGGAAGGAGGGTCTTTGATTTATGAAAAA
TTAGGAGAAAAGGCATTTGGATGGCCGGGAAAAATTGGAGCTTTTGTTTCCATTACAATG
CAGAACATTGGAGCAATGTCAAGCTACCTCTTTATCATTAAATATGAACTACCTGAAGTA
ATCAGAGCATTCATGGGACTTGAAGAAAATACTGGAGAATGGTACCTCAATGGCAACTAC
CTCATCATATTTGTGTCTGTTGGAATTATTCTTCCACTTTCGCTCCTTAAAAATTTAGGT
TATCTTGGCTATACCAGTGGATTTTCTCTTACCTGCATGGTGTTTTTTGTTAGTGTGGTG
ATTTACAAGAAATTCCAAATACCCTGCCCTCTACCTGTTTTGGATCACAGTGTTGGAAAT
CTGTCATTCAACAACACGCTTCCAATGCATGTGGTAATGTTACCCAACAACTCTGAGAGT
TCTGATGTGAACTTCATGATGGATTACACCCACCGCAATCCTGCAGGGCTGGATGAGAAC
CAGGCCAAGGGCTCTCTTCATGACAGTGGAGTAGAATATGAAGCTCATAGTGATGACAAG
TGTGAACCCAAATACTTTGTATTCAACTCCCGGACGGCCTATGCAATTCCTATCCTAGTA
TTTGCTTTTGTATGCCACCCTGAGGTCCTTCCCATCTACAGTGAACTTAAAGATCGGTCC
CGGAGAAAAATGCAAACGGTGTCAAATATTTCCATCACGGGGATGCTTGTCATGTACCTG
CTTGCCGCCCTCTTTGGTTACCTAACCTTCTATGGAGAAGTTGAAGATGAATTACTTCAT
GCCTACAGCAAAGTGTATACATTAGACATCCCTCTTCTCATGGTTCGCCTGGCAGTCCTT
GTGGCAGTAACACTAACTGTGCCCATTGTCCTCTTCCCAATTCGTACATCAGTGATCACA
CTGTTATTTCCCAAACGACCCTTCAGCTGGATACGACATTTCCTGATTGCAGCTGTGCTT
ATTGCACTTAATAATGTTCTGGTCATCCTTGTGCCAACTATAAAATACATCTTCGGATTC
ATAGGGGCTTCTTCTGCCACTATGCTGATTTTTATTCTTCCAGCAGTTTTTTATCTTAAA
CTTGTCAAGAAAGAAACTTTTAGGTCACCCCAAAAGGTCGGGGCTTTAATTTTCCTTGTG
GTTGGAATATTCTTCATGATTGGAAGCATGGCACTCATTATAATTGACTGGATTTATGAT
CCTCCAAATTCCAAGCATCACTAA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
AF305814

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_4_Locus:
12q13

# Macromolecular_Interacting_Partner_4_SNPs:
rs2429467; rs11183610; rs180414; rs2465604; rs2429472; rs2250010; rs2191162; rs2715788; rs2465608; rs2430921; rs4627160; rs11183605; rs180438; rs2897981; rs10881001; rs2079787; rs7974413; rs11183618; rs2429470; rs4482114; rs11183617; rs7963399; rs11183616; rs7967842; rs4587804; rs7132006; rs10161209; rs2109125; rs11183619; rs2465605; rs3862137; rs4569081; rs11183620; rs12321267; rs12582305; rs12424453; rs7968752; rs7954772; rs2429473; rs7963807; rs2465586; rs17097332; rs4447249; rs7138295; rs7959916; rs7953215; rs7973308; rs12304394; rs4491335; rs180437; rs12301396; rs10748455; rs2429471; rs12300935; rs4554975; rs12318696; rs10437941; rs7963364; rs10881002; rs7971412; rs7974393; rs12227634; rs17666239; rs12301345; rs11183621; rs17097341; rs10881003; rs180430; rs180431; rs2715779; rs2465585; rs180416; rs2465584; rs180421; rs1860372; rs180408; rs180433; rs180410; rs180409; rs180420; rs180417; rs7297226; rs4768758; rs2287471; rs180427; rs180419; rs2429474; rs4768759; rs2430922; rs2465583; rs6582676; rs180407; rs11183608; rs2465582; rs180434; rs180405; rs11183609; rs180426; rs180435; rs180412; rs2465644; rs12307687; rs180424; rs180429; rs180415; rs17097246; rs2075335; rs12305532; rs180428; rs12316767; rs2287472; rs12581848; rs12307218; rs4768757; rs180425; rs12317419; rs12306007; rs3794308; rs12301214; rs2302855; rs180423; rs180403; rs17097220; rs12313427; rs17602430; rs1860371; rs12826359; rs180422; rs2429465; rs2287473; rs17097286; rs11609184; rs2429466; rs180436; rs180404; rs1468970; rs1468972; rs1468971; rs2465614; rs4340151; rs2430920; rs2465613; rs12315893; rs7489259; rs7976413; rs7962993; rs7965688; rs7976286; rs4262792; rs12309262; rs35448881; rs5797999; rs12426237; rs34557682; rs10523982; rs12824626; rs2543339; rs4537845; rs34666594; rs2429469; rs10161451; rs34886536; rs5798000; rs4575359; rs11558891; rs9804926; rs10693721; rs4388977; rs2430923; rs2429468; rs34878223; rs3764027; rs2465606; rs2465588; rs35064296; rs17097355; rs34251832; rs12308177; rs1072246; rs2465587; rs4335624; rs5798001; rs2907513; rs12819255; rs4768756; rs2532606; rs11370884; rs34540549; rs12298652; rs34594658; rs4623983; rs35779004; rs35709312; rs2429464; rs10691485; rs12832145; rs35826321; rs180413; rs2216433; rs35066357; rs12319423; rs2465616; rs10691484; rs11610757; rs11315253; rs34637197; rs17097192; rs35050099; rs7313706; rs549755; rs36053062; rs11335369; rs3217194; rs11183614; rs12318924; rs4631970; rs34909119; rs12316757; rs180411; rs180432; rs10673975; rs34246069; rs35085914; rs180406; rs34654635; rs34189139; rs11335992; rs4439596; rs416435; rs35774013; rs5797998; rs3958775; rs35668113; rs446993; rs180418; rs34764764; rs34209899; rs11338774; rs10785645; rs11183625; rs11609070; rs11615573; rs12307895; rs12311057; rs12317975; rs12318756; rs12318994; rs12812119; rs17097368; rs17684703; rs2193649; rs2216432; rs2408623; rs2430917; rs2430919; rs2465595; rs2715775; rs2715783; rs4374015; rs4495962; rs4497488; rs4511364; rs4533116; rs4994910; rs7953233; rs7955552; rs7964210; rs7978689; rs7978822; rs7978926

# Macromolecular_Interacting_Partner_4_General_References:
11342143; 11414754

# Macromolecular_Interacting_Partner_4_References:
Not Available

# Macromolecular_Interacting_Partner_5_ID:
8783

# Macromolecular_Interacting_Partner_5_Name:
F19541_1

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
PRODH2

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>F19541_1
PSGLPLLPVLFALGGLLLLSNASCVGGVLWQRRLRRLAEALNFPPHLHPGRSEEDRVRNE
YEESQWTGERDTQSSTVSTTEAEPYYRSLRDFSPQLPPTQEEVSYSRGFTGEDEDMAFPG
HLYDEVERTYPPSGAWGPLYDEVQMGPWDLHWPEDTYQDPRGIYDQVAGDLDTLEPDSLP
FELRGHLVWGFNHVSQAGLKLLASSDPPASASQSAEITESHSVVQVGVQWRYFGSLHPLP
PGSRDSLASASRIAGITAPWEAEVSRSPQGTQDSPVTRSGPPSRGWQSLSFDGGAFHLKG
TGELTRALLVLRLCAWPPLVTHGLLLQAWSRRLLGSRLSGAFLRASVYGQFVAGETAEEV
KGCVQQLRTLSLRPLLAVPTEEEPDSAAKRMRLHHVGQAGLELLTPAASGSVAQAGVQWR
QSSDRGGGNQAAASRSSLLQEAAFSPPCGRLQLPAQPASRHGARGRGSMKAKSLTSRHLL
ASQGQETIIKTKVRIPALWKAEPGQHSKTPSQQNKSQYVTTLWEADVGRSLENLQVSCLN
AEQNQHLRASLSRLHRVTPPAGTSTSGPPSAACIGWHSRLHRVAQYARAQHVRLLVDAEY
TSLNPALSLLVAALAVRWNSPGEGGPWVWNTYQACLKDTFERLGRDAEAAHRAGLAFGVK
LVRGAYLDKERAVAQLHGMEDPTQPDYEATSELNRASPFSYSRCLELMLTHVARHGPMCH
LMVASHNEESVRQATKRMWELGIPLDGTVCFGQLLGMCDHVSLALGQAGYVVYKSIPYGS
LEEVIPYLIRRAQENRSVLQGARREQELLSQELWRRLLPGCRRIPH

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
826

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
90815

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
7.54

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
 Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  proline dehydrogenase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
Function:  subtilase activity
 ||
>>>
 Process:  proline metabolism
Process:  proline catabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamate metabolism
Process:  glutamate biosynthesis
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_5_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF01619:Pro_dh

# Macromolecular_Interacting_Partner_5_Signals:
1-22

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
7-29

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
2105420

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
O00420_HUMAN (O00420)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
PRODH2

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
PRODH2

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:17325

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>2483 bp
GACCCTCGGGGCTGCCCCTGCTGCCTGTGCTGTTCGCTCTTGGGGGGCTTCTGCTCCTCT
CCAATGCCTCCTGTGTCGGGGGGGTCCTCTGGCAGCGGAGACTCAGGCGTCTTGCTGAGG
CACTCAACTTCCCCCCACACCTTCATCCTGGAAGGTCGGAAGAGGACCGAGTCAGGAACG
AATATGAGGAGAGCCAGTGGACAGGAGAGCGGGACACTCAGAGCTCCACGGTCAGCACAA
CAGAGGCAGAGCCGTATTACCGCTCCCTGAGGGACTTCAGCCCCCAGCTGCCCCCGACGC
AGGAGGAGGTGTCTTATTCCCGAGGTTTCACAGGTGAAGATGAGGATATGGCCTTCCCTG
GGCACTTGTATGATGAGGTAGAAAGAACGTACCCCCCGTCTGGAGCCTGGGGACCCCTCT
ACGATGAAGTGCAGATGGGACCCTGGGACCTCCACTGGCCTGAAGACACATATCAGGATC
CAAGAGGAATCTATGACCAGGTGGCCGGAGACTTGGACACTCTGGAACCCGATTCTCTGC
CCTTCGAGCTGAGGGGACATCTGGTATGGGGTTTCAACCATGTTAGCCAGGCTGGTCTCA
AACTCCTGGCCTCAAGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGAGATTACAGAGT
CTCACTCTGTAGTCCAGGTTGGAGTGCAGTGGCGTTATTTCGGCTCACTGCATCCTCTGC
CTCCTGGTTCAAGAGATTCTCTTGCCTCAGCCTCCCGCATAGCTGGGATTACAGCACCTT
GGGAGGCAGAGGTGAGCAGATCACCTCAGGGCACTCAGGATTCCCCAGTGACCAGGTCTG
GTCCCCCCTCCAGGGGCTGGCAGTCCCTGAGCTTTGATGGCGGGGCCTTCCACCTTAAGG
GCACAGGAGAGCTGACACGGGCCTTGCTGGTTCTCCGGCTGTGTGCCTGGCCCCCACTCG
TCACTCACGGGCTGTTGCTCCAGGCCTGGTCTCGGCGACTCCTGGGCTCCCGGCTCTCAG
GCGCATTTCTCCGAGCATCCGTCTATGGGCAGTTTGTGGCTGGTGAGACAGCAGAGGAGG
TGAAGGGCTGCGTGCAGCAGCTGCGGACCCTCAGCCTCCGACCACTGCTGGCAGTGCCCA
CTGAGGAGGAGCCGGACTCTGCTGCCAAGAGGATGAGGCTTCACCATGTTGGCCAGGCTG
GTCTTGAACTCCTGACCCCAGCGGCATCTGGCTCTGTTGCCCAGGCTGGAGTGCAGTGGA
GACAATCCTCTGACAGGGGAGGAGGAAACCAGGCTGCTGCCTCCAGGTCTTCCCTTCTCC
AGGAGGCAGCATTCTCCCCACCATGCGGAAGGTTGCAGCTTCCAGCCCAACCTGCCTCCA
GACACGGTGCTAGGGGCCGAGGAAGCATGAAGGCAAAATCCCTGACCTCGAGGCACTTAC
TTGCAAGTCAGGGGCAAGAGACAATAATTAAAACCAAAGTCAGAATCCCAGCACTTTGGA
AGGCTGAGCCTGGGCAACACAGCAAGACCCCGTCTCAGCAAAACAAAAGTCAGTACGTAA
CAACACTTTGGGAGGCCGATGTGGGCAGATCACTTGAGAACCTCCAGGTCTCCTGCCTCA
ATGCTGAGCAGAACCAGCACCTCCGGGCCTCCCTCAGCCGCCTGCATCGGGTAACCCCTC
CTGCTGGAACCAGCACCTCCGGGCCTCCCTCTGCCGCCTGCATTGGGTGGCACAGCCGCC
TGCATCGGGTGGCACAGTATGCCCGGGCCCAGCACGTGCGGCTCCTGGTGGATGCGGAGT
ACACCTCACTGAACCCTGCGCTCTCGCTGCTGGTGGCTGCCCTGGCTGTGCGCTGGAACA
GCCCGGGTGAAGGCGGGCCCTGGGTGTGGAACACCTACCAGGCCTGTCTAAAGGACACAT
TCGAGCGGCTGGGGAGGGATGCAGAGGCTGCGCACAGGGCCGGCCTGGCCTTCGGAGTGA
AGCTGGTACGAGGTGCATATCTGGACAAGGAGAGAGCGGTGGCCCAGCTCCATGGGATGG
AAGACCCCACTCAGCCTGACTATGAGGCCACCAGTGAGCTGAACAGAGCATCTCCCTTCA
GTTACAGCCGCTGCCTGGAACTGATGCTGACGCACGTGGCCCGCCATGGCCCCATGTGCC
ACCTCATGGTGGCTTCCCACAATGAGGAATCTGTTCGCCAGGCAACCAAGCGCATGTGGG
AGCTGGGCATTCCTCTGGATGGGACTGTCTGTTTCGGACAACTTCTGGGCATGTGTGACC
ACGTCTCTCTAGCACTGGGGCAGGCCGGCTATGTAGTGTATAAGTCCATTCCCTATGGCT
CCTTGGAGGAGGTAATCCCCTACCTGATCCGGAGGGCCCAGGAGAACCGGAGCGTGCTTC
AGGGTGCCCGCAGGGAACAGGAGCTGCTCAGCCAAGAACTGTGGCGGCGGCTGCTGCCAG
GATGCCGAAGGATACCCCACTAG

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
U95090

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_5_Locus:
19q13.1

# Macromolecular_Interacting_Partner_5_SNPs:
rs3761097; rs3848666; rs3761096; rs12462360; rs28563032; rs401522; rs7252583; rs3761086; rs11671781; rs11672640; rs7260272; rs8103287; rs11880250; rs11668859; rs4805139; rs13313721; rs35841154; rs35221778; rs1133745; rs34271568; rs8103616; rs7249416; rs35737326; rs7507463; rs35586715; rs35750728; rs3030901; rs35470025; rs8103488; rs34796821; rs10411242; rs34773423; rs3042740; rs35647192; rs11670603; rs9749422; rs12983479; rs10676244; rs34269666; rs3030903; rs10676004; rs36082235; rs10401236; rs28502060; rs3042738; rs409792; rs34653403; rs3761095; rs3761085; rs35994447; rs10427023; rs4045926; rs2312051; rs28368300; rs13313722; rs35943724; rs416341; rs7508063; rs7257630; rs36045758; rs10413461; rs11668331; rs11671256; rs11881242; rs11882473; rs11883199; rs12610011; rs12610798; rs12611214; rs17777002; rs231236; rs2520313; rs2520314; rs2619200; rs2619201; rs2619202; rs2619203; rs3170506; rs35092745; rs7248909; rs807492; rs807493

# Macromolecular_Interacting_Partner_5_General_References:
Not Available

# Macromolecular_Interacting_Partner_5_References:
Not Available

# Macromolecular_Interacting_Partner_6_ID:
8833

# Macromolecular_Interacting_Partner_6_Name:
Sodium-dependent proline transporter

# Macromolecular_Interacting_Partner_6_Synonyms:
Solute carrier family 6 member 7

# Macromolecular_Interacting_Partner_6_Gene_Name:
SLC6A7

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Sodiumdependent proline transporter
MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNV
WRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGA
AMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALP
LNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSG
KVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLG
VGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVA
KAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLR
PKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQ
RFCRDIHMMLGFKPGLYFRACWLFLSPATLLALLVYSIVKYQPSEYGSYRFPPWAELLGI
LMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQS
PKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
636

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
70893

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
6.66

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
 Function:  transporter activity
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_6_Signals:
1-238

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
46-66
74-93
117-137
215-233
242-259
295-312
324-345
378-397
425-443
459-479
500-519
538-556

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
SC6A7_HUMAN (Q99884)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SLC6A7

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SLC6A7

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:11054

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
S80071

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_6_Locus:
5q31-q32

# Macromolecular_Interacting_Partner_6_SNPs:
rs4705426; rs2240794; rs2240793; rs17111043; rs13153325; rs6579779; rs2240795; rs3764886; rs2240785; rs758593; rs2240792; rs731376; rs2240786; rs10076748; rs2240788; rs2270147; rs4705425; rs9885318; rs7704850; rs11954180; rs4705429; rs2270146; rs11749558; rs2240791; rs917585; rs4705430; rs12652602; rs6579778; rs4705427; rs13360134; rs11951929; rs13153971; rs2286642; rs758590; rs3776085; rs2270145; rs2270148; rs2240784; rs2270149; rs3815375; rs17652561; rs2240783; rs6579777; rs3733680; rs13171447; rs2079792; rs10875556; rs4516843; rs4601032; rs17652448; rs11745084; rs2286639; rs2240790; rs13180055; rs4996004; rs3776087; rs2240787; rs2880320; rs17111008; rs9324642; rs2286640; rs17708892; rs2240789; rs7727022; rs3756317; rs3756316; rs3776084; rs3776083; rs1860408; rs3756318; rs2342277; rs1468564; rs35844281; rs4705114; rs13169575; rs10078509; rs12653451; rs3822326; rs5024533; rs4705422; rs34296754; rs7725656; rs2342282; rs758592; rs17111013; rs41287116; rs35444275; rs4705428; rs731375; rs3776088; rs10586393; rs10638433; rs11428067; rs5872164; rs2286641; rs3776086; rs33935071; rs34262805; rs33929181; rs10717026; rs34568002; rs4423986; rs34493121; rs34805083; rs2342283; rs5872163; rs729817; rs5872166; rs34462816; rs33993267; rs12517671; rs10675929; rs35380195; rs7725994; rs2342280; rs33952929; rs10530999; rs10051673; rs5872162; rs34840715; rs34186025; rs33924099; rs17615170; rs34154262; rs35731331; rs35252459; rs33952116; rs13436291; rs758591; rs34142314; rs2342278; rs2342279; rs41287118; rs5024534; rs6881185; rs35667782; rs5872165; rs13161227; rs17111012; rs34585658; rs4705113; rs35029936; rs10586394; rs2342281; rs9986200; rs6878880; rs13170839; rs35373527; rs10058507; rs34200115; rs2058235; rs3756319; rs1860409; rs35419082; rs35242803; rs10043606; rs10063514; rs10463230; rs1056039; rs11949593; rs11950723; rs11952746; rs11953756; rs12514325; rs17111051; rs17111053; rs2098099; rs2163766; rs2240782; rs2286643; rs2286644; rs2880319; rs34266615; rs34668378; rs3933449; rs4705115; rs4705419; rs4705420; rs4705421; rs4705431; rs4705432; rs6869490; rs6871424; rs6873782; rs6873984; rs6874166; rs6876869; rs6882623; rs6890699; rs6890948; rs6891286; rs6895585; rs6896067; rs734593; rs7729083; rs882354; rs887345; rs887346; rs887347; rs887348; rs980272

# Macromolecular_Interacting_Partner_6_General_References:
7651355

# Macromolecular_Interacting_Partner_6_References:
Not Available

End of HMDB00162

Beginning of HMDB00163
# Accession_No:
HMDB00163

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-02 10:00:39

# biospider_lastupdate:
2007-08-02 10:01:33

# Common_Name:
D-Maltose

# Description:
Maltose, or malt sugar, is a primary disaccharide in the human diet formed from two units of glucose joined with an alpha (1->4) linkage. It is the second member of an important biochemical series of glucose chains. The addition of another glucose unit yields maltotriose, Further additions will produce dextrins, also called maltodextrins, and eventually starch. Maltose can be broken down into two glucose molecules by hydrolysis in living organisms. At the surface of the small intestine, the brush border enzymes maltase, breaks down maltose. (PMID: 14522745)

# Synonyms:
alpha-Malt sugar; alpha-D-glucopyranosyl-(1->4)-D-glucose; alpha-D-glucopyranosyl-(1->4)-D-glucopyranose; alpha-D-Glcp-(1->4)-D-Glcp; Sunmalt S; Sunmalt; Martos-10; Malzzucker; Maltose solution; Maltose HHH; Maltose HH; Maltose; Maltos; Maltodiose; Maltobiose; Malt sugar; Madoros (TN); Madoros; Finetose F; Finetose; D-Maltose; D-(+)-maltose; Cextromaltose; Advantose 100; 4-O-alpha-D-glucopyranosyl-D-glucose; 4-O-alpha-D-glucopyranosyl-D-glucopyranose; 4-O-a-D-Glucopyranosyl-D-glucose; 4-(alpha-D-glucosido)-D-glucose; 4-(alpha-D-glucopyranosido)-alpha-glucopyranose; 1-alpha-D-Glucopyranosyl-4-alpha-D-glucopyranose; alpha-delta-glucopyranosyl-(1->4)-delta-glucose; alpha-delta-glucopyranosyl-(1->4)-delta-glucopyranose; alpha-delta-Glcp-(1->4)-delta-Glcp; delta-Maltose; delta-(+)-maltose; 4-O-alpha-delta-glucopyranosyl-delta-glucose; 4-O-alpha-delta-glucopyranosyl-delta-glucopyranose; 4-(alpha-delta-glucosido)-delta-glucose; 4-(alpha-delta-glucopyranosido)-alpha-glucopyranose; 1-alpha-delta-Glucopyranosyl-4-alpha-delta-glucopyranose

# Chemical_IUPAC_Name:
(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol

# Chemical_Formula:
C12H22O11

# Chemical_Structure:
tbl_chemical:::HMDB00163_ZOOM.png:::119283228229830514

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00163_THUMB.png:::119283228024551710

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Sugars; Disaccharides

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiacetal; acetal; primary alcohol; secondary alcohol; 1,2-diol; heterocyclic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
342.11621

# Molecular_Weight_Avg:
342.29651

# Smiles_String_isomeric:
OC[C@H]1O[C@H](O[C@@H]2[C@@H](CO)OC(O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

# Smiles_String_canonical:
OCC1OC(OC2C(CO)OC(O)C(O)C2O)C(O)C(O)C1O

# KEGG_Compound_ID:
C00208

# BioCyc_ID:
MALTOSE

# PubChem_CID:
439186

# PubChem_SID:
24882612; 8144199; 3508; 16123870; 10298236; 7847112

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
34261

# Wikipedia_ID:
Malt sugar

# METLIN_ID:
413

# Ref_ID:
9773376; 12010829; 3275321; 2787774; 1864083; 215341; 7202948; 16113331; 8782684; 2463752; 8186098; 16602718; 8242677; 10527944; 8496948; 15309310; 376499; 3092303; 902663; 1339284

# ChEBI_ID:
17306

# CAS_Registry_Number:
69-79-4

# InChI:
InChI=1/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5-,6+,7-,8-,9-,10-,11?,12-/m1/s1

# Synthesis_Reference:
Journal of Molecular Catalysis B: Enzymatic  (2000),  10(6),  617-621.

# Melting_Point:
102-103 oC

# Melting_Point_predicted:
140.9 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
780.0 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
586.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-5.03 [MEYLAN,WM & HOWARD,PH (1995)]; -4.3 [Predicted by PubChem via XLOGP]; -3.00 [Predicted by ALOGPS]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00163.mol:::118607049612324656

# SDF_File_[Text]:
tbl_chemical:::HMDB00163.sdf:::119283227568813280

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00163.pdb:::119283227886957801

# PDB_ID:
1A7L

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::050125_P00_03_IS_1DP_PRESAT_expanded_1.gif:::114460738675333039

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::050125_P00_03_IS_1DP_presat.zip:::1177710630379821786

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050125_P00_03_IS_1DP_Assigned.png:::116560882268366798

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::050125_P00_03_IS_1DC_8.jpg:::114168392124025805

# C_NMR_FIDS_Spectra:
tbl_cnmr:::050125_P00_03_IS_1DC_8.zip:::114168392119941087

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::050125_P00_03_IS_1DC_8_Assigned.jpg:::116112066941432371

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050125_P00_03_IS_2DHSQC_79.jpg:::114805757584317912

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050125_P00_03_IS_2DHSQC_79.zip:::114805757591634358

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050125_P00_03_IS_2DHSQC_79_Assigned.jpg:::116112074099796211

# Predicted_H_NMR_Spectrum:
tbl_chemical:::HMDB00163.gif:::1180770626869446592

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00163_peaks.txt:::1180770489921364448

# Predicted_C_NMR_Spectrum:
tbl_chemical:::HMDB00163_C.gif:::1180770696110964211

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00163_peaks.txt:::1180770558449784631

# Mass_Spectrum:
tbl_chemical:::HMDB00163.jpg:::1132798877937994643

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000017.png:::116890822451545598

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000017.txt:::116890822451578711

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000017.png:::11689082241095798

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000017.txt:::1168908224515436

# Cellular_Location:
Cytoplasm; Extracellular; lysosome

# Tissue_Location:
Platelets

# deuterated:
No

# Biofluid_Location:
Not Available

# Concentration_[Normal]:
Not Available


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Diuresis; Pompe Disease

# Pathway_Names:
Galactose metabolism;Starch and sucrose metabolism

# Pathway_Images:
;

# KEGG_Images:
map00052;map00500

# Pathway_Graphs:
;

# Pathway_SBMLs:
;

# Metabolic_Enzyme_1_ID:
5603

# Metabolic_Enzyme_1_Name:
Glycogen debranching enzyme

# Metabolic_Enzyme_1_Synonyms:
Glycogen debrancher[Includes: 4-alpha- glucanotransferase; Oligo-1,4-1,4-glucantransferase; Amylo-alpha-1,6-glucosidase; Amylo-1,6-glucosidase; Dextrin 6-alpha-D-glucosidase]

# Metabolic_Enzyme_1_Gene_Name:
AGL

# Metabolic_Enzyme_1_Protein_Sequence:
>Glycogen debranching enzyme
MGHSKQIRILLLNEMEKLEKTLFRLEQGYELQFRLGPTLQGKAVTVYTNYPFPGETFNRE
KFRSLDWENPTEREDDSDKYCKLNLQQSGSFQYYFLQGNEKSGGGYIVVDPILRVGADNH
VLPLDCVTLQTFLAKCLGPFDEWESRLRVAKESGYNMIHFTPLQTLGLSRSCYSLANQLE
LNPDFSRPNRKYTWNDVGQLVEKLKKEWNVICITDVVYNHTAANSKWIQEHPECAYNLVN
SPHLKPAWVLDRALWRFSCDVAEGKYKEKGIPALIENDHHMNSIRKIIWEDIFPKLKLWE
FFQVDVNKAVEQFRRLLTQENRRVTKSDPNQHLTIIQDPEYRRFGCTVDMNIALTTFIPH
DKGPAAIEECCNWFHKRMEELNSEKHRLINYHQEQAVNCLLGNVFYERLAGHGPKLGPVT
RKHPLVTRYFTFPFEEIDFSMEESMIHLPNKACFLMAHNGWVMGDDPLRNFAEPGSEVYL
RRELICWGDSVKLRYGNKPEDCPYLWAHMKKYTEITATYFQGVRLDNCHSTPLHVAEYML
DAARNLQPNLYVVAELFTGSEDLDNVFVTRLGISSLIREAMSAYNSHEEGRLVYRYGGEP
VGSFVQPCLRPLMPAIAHALFMDITHDNECPIVHRSAYDALPSTTIVSMACCASGSTRGY
DELVPHQISVVSEERFYTKWNPEALPSNTGEVNFQSGIIAARCAISKLHQELGAKGFIQV
YVDQVDEDIVAVTRHSPSIHQSVVAVSRTAFRNPKTSFYSKEVPQMCIPGKIEEVVLEAR
TIERNTKPYRKDENSINGTPDITVEIREHIQLNESKIVKQAGVATKGPNEYIQEIEFENL
SPGSVIIFRVSLDPHAQVAVGILRNHLTQFSPHFKSGSLAVDNADPILKIPFASLASRLT
LAELNQILYRCESEEKEDGGGCYDIPNWSALKYAGLQGLMSVLAEIRPKNDLGHPFCNNL
RSGDWMIDYVSNRLISRSGTIAEVGKWLQAMFFYLKQIPRYLIPCYFDAILIGAYTTLLD
TAWKQMSSFVQNGSTFVKHLSLGSVQLCGVGKFPSLPILSPALMDVPYRLNEITKEKEQC
CVSLAAGLPHFSSGIFRCWGRDTFIALRGILLITGRYVEARNIILAFAGTLRHGLIPNLL
GEGIYARYNCRDAVWWWLQCIQDYCKMVPNGLDILKCPVSRMYPTDDSAPLPAGTLDQPL
FEVIQEAMQKHMQGIQFRERNAGPQIDRNMKDEGFNITAGVDEETGFVYGGNRFNCGTWM
DKMGESDRARNRGIPATPRDGSAVEIVGLSKSAVRWLLELSKKNIFPYHEVTVKRHGKAI
KVSYDEWNRKIQDNFEKLFHVSEDPSDLNEKHPNLVHKRGIYKDSYGASSPWCDYQLRPN
FTIAMVVAPELFTTEKAWKALEIAEKKLLGPLGMKTLDPDDMVYCGIYDNALDNDNYNLA
KGFNYHQGPEWLWPIGYFLRAKLYFSRLMGPETTAKTIVLVKNVLSRHYVHLERSPWKGL
PELTNENAQYCPFSCETQAWSIATILETLYDL

# Metabolic_Enzyme_1_Number_of_Residues:
1532

# Metabolic_Enzyme_1_Molecular_Weight:
174766

# Metabolic_Enzyme_1_Theoretical_pI:
6.74

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  4-alpha-glucanotransferase activity
Function:  catalytic activity
Function:  glycogen debranching enzyme activity
Function:  amylo-alpha-1,6-glucosidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  polysaccharide metabolism
Process:  cellular polysaccharide metabolism
Process:  glucan metabolism
Process:  glycogen metabolism
Process:  glycogen biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6- glucosidase in glycogen degradation

# Metabolic_Enzyme_1_Pathway:
map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_1_Reaction:
Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF06202:GDE_C

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.1.25;EC 3.2.1.33

# Metabolic_Enzyme_1_GenBank_ID_Protein:
187577

# Metabolic_Enzyme_1_SwissProt_ID:
GDE_HUMAN (P35573)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
AGL

# Metabolic_Enzyme_1_Geneatlas_id:
AGL

# Metabolic_Enzyme_1_hgnc_id:
HGNC:321

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>4548 bp
ATGAGTTTATTAACATGTGCTTTTTATTTAGGGTATGAGCTACAGTTCCGATTAGGCCCA
ACTTTACAGGGAAAAGCAGTTACCGTGTATACAAATTACCCATTTCCTGGAGAAACATTT
AATAGAGAAAAATTCCGTTCTCTGGATTGGGAAAATCCAACAGAAAGAGAAGATGATTCT
GATAAATACTGTAAACTTAATCTGCAACAATCTGGTTCATTTCAGTATTATTTCCTTCAA
GGAAATGAGAAAAGTGGTGGAGGTTACATAGTTGTGGACCCCATTTTACGTGTTGGTGCT
GATAATCATGTGCTACCCTTGGACTGTGTTACTCTTCAGACATTTTTAGCTAAGTGTTTG
GGACCTTTTGATGAATGGGAAAGCAGACTTAGGGTTGCAAAAGAATCAGGCTACAACATG
ATTCATTTTACCCCATTGCAGACTCTTGGACTATCTAGGTCATGCTACTCCCTTGCCAAT
CAGTTAGAATTAAATCCTGACTTTTCAAGACCTAATAGAAAGTATACCTGGAATGATGTT
GGACAGCTAGTGGAAAAATTAAAAAAGGAATGGAATGTTATTTGTATTACTGATGTTGTC
TACAATCATACTGCTGCTAATAGTAAATGGATCCAGGAACATCCAGAATGTGCCTATAAT
CTTGTGAATTCTCCACACTTAAAACCTGCCTGGGTCTTAGACAGAGCACTTTGGCGTTTC
TCCTGTGATGTTGCAGAAGGGAAATACAAAGAAAAGGGAATACCTGCTTTGATTGAAAAT
GATCACCATATGAATTCCATCCGAAAAATAATTTGGGAGGATATTTTTCCAAAGCTTAAA
CTCTGGGAATTTTTCCAAGTAGATGTCAACAAAGCGGTTGAGCAATTTAGAAGACTTCTT
ACACAAGAAAATAGGCGAGTAACCAAGTCTGATCCAAACCAACACCTTACGATTATTCAA
GATCCTGAATACAGACGGTTTGGCTGTACTGTAGATATGAACATTGCACTAACGACTTTC
ATACCACATGACAAGGGGCCAGCAGCAATTGAAGAATGCTGTAATTGGTTTCATAAAAGA
ATGGAGGAATTAAATTCAGAGAAGCATCGACTCATTAACTATCATCAGGAACAGGCAGTT
AATTGCCTTTTGGGAAATGTGTTTTATGAACGACTGGCTGGCCATGGTCCAAAACTAGGA
CCTGTCACTAGAAAGCATCCTTTAGTTACCAGGTATTTTACTTTCCCATTTGAAGAGATA
GACTTCTCCATGGAAGAATCTATGATTCATCTGCCAAATAAAGCTTGTTTTCTGATGGCA
CACAATGGATGGGTAATGGGAGATGATCCTCTTCGAAACTTTGCTGAACCGGGTTCAGAA
GTTTACCTAAGGAGAGAACTTATTTGCTGGGGAGACAGTGTTAAATTACGCTATGGGAAT
AAACCAGAGGACTGTCCTTATCTCTGGGCACACATGAAAAAATACACTGAAATAACTGCA
ACTTATTTCCAGGGAGTACGTCTTGATAACTGCCACTCAACACCTCTTCACGTAGCTGAG
TACATGTTGGATGCTGCTAGGAATTTGCAACCCAATTTATATGTAGTAGCTGAACTGTTC
ACAGGAAGTGAAGATCTGGACAATGTCTTTGTTACTAGACTGGGCATTAGTTCCTTAATA
AGAGAGGCAATGAGTGCATATAATAGTCATGAAGAGGGCAGATTAGTTTACCGATATGGA
GGAGAACCTGTTGGATCCTTTGTTCAGCCCTGTTTGAGGCCTTTAATGCCAGCTATTGCA
CATGCCCTGTTTATGGATATTACGCATGATAATGAGTGTCCTATTGTGCATAGATCAGCG
TATGATGCTCTTCCAAGTACTACAATTGTTTCTATGGCATGTTGTGCTAGTGGAAGTACA
AGAGGCTATGATGAATTAGTGCCTCATCAGATTTCAGTGGTTTCTGAAGAACGGTTTTAC
ACTAAGTGGAATCCTGAAGCATTGCCTTCAAACACAGGTGAAGTTAATTTCCAAAGCGGC
ATTATTGCAGCCAGGTGTGCTATCAGTAAACTTCATCAGGAGCTTGGAGCCAAGGGTTTT
ATTCAGGTGTATGTGGATCAAGTTGATGAAGACATAGTGGCAGTAACAAGACACTCACCT
AGCATCCATCAGTCTGTTGTGGCTGTATCTAGAACTGCTTTCAGGAATCCCAAGACTTCA
TTTTACAGCAAGGAAGTGCCTCAAATGTGCATCCCTGGCAAAATTGAAGAAGTAGTTCTT
GAAGCTAGAACTATTGAGAGAAACACGAAACCTTATAGGAAGGATGAGAATTCAATCAAT
GGAACACCAGATATCACAGTAGAAATTAGAGAACATATTCAGCTTAATGAAAGTAAAATT
GTTAAACAAGCTGGAGTTGCCACAAAAGGGCCCAATGAATATATTCAAGAAATAGAATTT
GAAAACTTGTCTCCAGGAAGTGTTATTATATTCAGAGTTAGTCTTGATCCACATGCACAA
GTCGCTGTTGGAATTCTTCGAAATCATCTGACACAATTCAGTCCTCACTTTAAATCTGGC
AGCCTAGCTGTTGACAATGCAGATCCTATATTAAAAATTCCTTTTGCTTCTCTTGCCTCC
AGATTAACTTTGGCTGAGCTAAATCAGATCCTTTACCGATGTGAATCAGAAGAAAAGGAA
GATGGTGGAGGGTGCTATGACATACCAAACTGGTCAGCCCTTAAATATGCAGGTCTTCAA
GGTTTAATGTCTGTATTGGCAGAAATAAGACCAAAGAATGACTTGGGGCATCCTTTTTGT
AATAATTTGAGATCTGGAGATTGGATGATTGACTATGTCAGTAACCGGCTTATTTCACGA
TCAGGAACTATTGCTGAAGTTGGTAAATGGTTGCAGGCTATGTTCTTCTACCTGAAGCAG
ATCCCACGTTACCTTATCCCATGTTACTTTGATGCTATATTAATTGGTGCATATACCACT
CTTCTGGATACAGCATGGAAGCAGATGTCAAGCTTTGTTCAGAATGGTTCAACCTTTGTG
AAACACCTTTCATTGGGTTCAGTTCAACTGTGTGGAGTAGGAAAATTCCCTTCCCTGCCA
ATTCTTTCACCTGCCCTAATGGATGTACCTTATAGGTTAAATGAGATCACAAAAGAAAAG
GAGCAATGTTGTGTTTCTCTAGCTGCAGGCTTACCTCATTTTTCTTCTGGTATTTTCCGC
TGCTGGGGAAGGGATACTTTTATTGCACTTAGAGGTATACTGCTGATTACTGGACGCTAT
GTAGAAGCCAGGAATATTATTTTAGCATTTGCGGGTACCCTGAGGCATGGTCTCATTCCT
AATCTACTGGGTGAAGGGATTTATGCCAGATACAATTGTCGGGATGCTGTGTGGTGGTGG
CTGCAGTGTATCCAGGATTACTGTAAAATGGTTCCAAATGGTCTAGACATTCTCAAGTGC
CCAGTTTCCAGAATGTATCCTACAGATGATTCTGCTCCTTTGCCTGCTGGCACACTGGAT
CAGCCATTGTTTGAAGTCATACAGGAAGCAATGCAAAAACACATGCAGGGCATACAGTTC
CGAGAAAGGAATGCTGGTCCCCAGATAGATCGAAACATGAAGGACGAAGGTTTTAATATA
ACTGCAGGAGTTGATGAAGAAACAGGATTTGTTTATGGAGGAAATCGTTTCAATTGTGGC
ACATGGATGGATAAAATGGGAGAAAGTGACAGAGCTAGAAACAGAGGAATCCCAGCCACA
CCAAGAGATGGGTCTGCTGTGGAAATTGTGGGCCTGAGTAAATCTGCTGTTCGCTGGTTG
CTGGAATTATCCAAAAAAAATATTTTCCCTTATCATGAAGTCACAGTAAAAAGACATGGA
AAGGCTATAAAGGTCTCATATGATGAGTGGAACAGAAAAATACAAGACAACTTTGAAAAG
CTATTTCATGTTTCCGAAGACCCTTCAGATTTAAATGAAAAGCATCCAAATCTGGTTCAC
AAACGTGGCATATACAAAGATAGTTATGGAGCTTCAAGTCCTTGGTGTGACTATCAGCTC
AGGCCTAATTTTACCATAGCAATGGTTGTGGCCCCTGAGCTCTTTACTACAGAAAAAGCA
GGGAAAGCTTTGGAGATTGCAGAAAAAAAATTGCTTGGTCCCCTTGGCATGAAAACTTTA
GATCCAGATGATATGGTTTACTGTGGAATTTATGACAATGCATTAGACAATGACAACTAC
AATCTTGCTAAAGGTTTCAATTATCACCAAGGACCTGAGTGGCTGTGGCCTATTGGGTAT
TTTCTTCGTGCAAAATTATATTTTTCCAGATTGATGGGCCCGGAGACTACTGCAAAGACT
ATAGTTTTGGTTAAAAATGTTCTTTCCCGACATTATGTTCATCTTGAGAGATCCCCTTGG
AAAGGACTTCCAGAACTGACCAATGAGAATGCCCAGTACTGTCCTTTCAGCTGTGAAACA
CAAGCCTGGTCAATTGCTACTATTCTTGAGACACTTTATGATTTATAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M85168

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_1_Locus:
1p21

# Metabolic_Enzyme_1_SNPs:
rs7536086; rs17121403; rs17121464; rs3753494; rs11807956; rs2230308; rs3736297; rs34714252; rs35278779; rs12043139; rs2230306; rs2230305; rs28730706; rs1804809; rs1804808; rs3766601; rs3766591; rs3766600; rs2307130; rs2307129; rs3766603; rs7513618; rs17121319; rs663848; rs12563807; rs12117747; rs2640911; rs628842; rs512237; rs569488; rs633127; rs634880; rs555929; rs574592; rs1493616; rs2035960; rs2291637; rs2814038; rs632699; rs631797; rs602700; rs618539; rs844323; rs494740; rs3766599; rs3766594; rs903126; rs2274570; rs659030; rs3766595; rs2035958; rs700537; rs2234707; rs655435; rs11166369; rs6577145; rs3766597; rs3820156; rs486408; rs2035961; rs2392077; rs12038567; rs598488; rs6577141; rs7528537; rs3736295; rs10875274; rs620281; rs6577148; rs656572; rs535461; rs590623; rs3766596; rs10783121; rs10747505; rs11166375; rs6692695; rs6577144; rs1541041; rs10875275; rs6577149; rs2291638; rs489681; rs594249; rs3820157; rs3820155; rs538389; rs17409324; rs481102; rs11166366; rs579660; rs619445; rs17121609; rs3736296; rs6577143; rs3753491; rs12039074; rs11581066; rs10783123; rs11166364; rs11166371; rs12080767; rs482825; rs903125; rs7519706; rs11800612; rs2769699; rs539157; rs3753490; rs17121466; rs2784169; rs3766593; rs17450126; rs6577142; rs572231; rs653389; rs494626; rs672069; rs3818568; rs515957; rs12035706; rs2296885; rs11166368; rs2769698; rs11166367; rs577954; rs1577541; rs11805563; rs492032; rs17448792; rs567596; rs6674610; rs530824; rs4307591; rs11166361; rs4908033; rs7554495; rs17450460; rs4907900; rs10783122; rs6659531; rs2307533; rs11166374; rs600777; rs17121546; rs685108; rs834575; rs11166363; rs17121622; rs7552875; rs687979; rs12073608; rs1932442; rs17121571; rs7555316; rs534662; rs17121617; rs12141927; rs7526847; rs6577146; rs12045983; rs17121414; rs6676595; rs4908034; rs578793; rs17121580; rs12754517; rs531015; rs6665958; rs12756830; rs686654; rs3753492; rs12086095; rs6577147; rs17121644; rs11166370; rs17121583; rs10157467; rs17121560; rs3766592; rs971245; rs17121311; rs3753486; rs28730701; rs41285738; rs28730708; rs12118058; rs41285740; rs34230588; rs34187957; rs34314491; rs11459891; rs35402482; rs11363065; rs1042291; rs12045176; rs41285742; rs41285736; rs1042285; rs3835491; rs34100797; rs35386840; rs496379; rs12757018; rs12732272; rs35486459; rs7410954; rs34696246; rs6669911; rs34941922; rs11308048; rs11354427; rs35373898; rs12035163; rs2640917; rs36007479; rs5776495; rs7533378; rs34561608; rs481932; rs35451680; rs12089187; rs34150660; rs34414844; rs2784168; rs12039154; rs4589132; rs6659534; rs10631915; rs34936033; rs674923; rs28730707; rs34530728; rs584264; rs36042909; rs17121634; rs12760862; rs9434035; rs684047; rs35532025; rs518500; rs6659536; rs3753493; rs11166372; rs34675960; rs12744819; rs11166362; rs479102; rs12734255; rs10628111; rs35274839; rs34177499; rs6674718; rs613762; rs6701460; rs638061; rs661874; rs34959224; rs2769697; rs34057901; rs3834029; rs11396034; rs12734024; rs28730703; rs11299217; rs35461239; rs34432483; rs4907898; rs11298471; rs548255; rs17121509; rs11275374; rs683214; rs10606259; rs1070281; rs700538; rs34782984; rs11372707; rs683124; rs2814039; rs571608; rs545045; rs1389381; rs6685484; rs2640916; rs34959197; rs12742273; rs28730704; rs34892303; rs12026350; rs34598850; rs7554622; rs12045937; rs35430266; rs34375591; rs35306093; rs834664; rs34401149; rs6659532; rs11368135; rs34531887; rs11166365; rs28730702; rs6691199; rs12092860; rs542508; rs10536621; rs12756297; rs3956694; rs7533698; rs11279753; rs35529979; rs11291815; rs6674605; rs35353104; rs34764737; rs649184; rs28468683; rs12045385; rs10631914; rs35114973; rs12730946; rs4907899; rs11438303; rs12037862; rs35740001; rs10615193; rs12729314; rs34853132; rs11166359; rs28575824; rs12092273; rs12143270; rs34436422; rs35956186; rs28474918; rs11166373; rs12742594; rs35616696; rs35773080; rs6674973; rs12734023; rs10637207; rs35513593; rs2814040; rs35650560; rs566460; rs12125517; rs34944425; rs35856689; rs11579334; rs11805862; rs12728741; rs17121306; rs2149188; rs2149189; rs2392075; rs4908036; rs501014; rs520644; rs573196; rs645956; rs6659858; rs6681572; rs6704456

# Metabolic_Enzyme_1_General_References:
1374391; 8954797; 9332391; 10982190; 10571954

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6258

# Metabolic_Enzyme_2_Name:
DNA polymerase epsilon subunit 2

# Metabolic_Enzyme_2_Synonyms:
DNA polymerase II subunit 2; DNA polymerase epsilon subunit B

# Metabolic_Enzyme_2_Gene_Name:
POLE2

# Metabolic_Enzyme_2_Protein_Sequence:
>DNA polymerase epsilon subunit 2
MAPERLRSRALSAFKLRGLLLRGEAIKYLTEALQSISELELEDKLEKIINAVEKQPLSSN
MIERSVVEAAVQECSQSVDETIEHVFNIIGAFDIPRFVYNSERKKFLPLLMTNHPAPNLF
GTPRDKAEMFRERYTILHQRTHRHELFTPPVIGSHPDESGSKFQLKTIETLLGSTTKIGD
AIVLGMITQLKEGKFFLEDPTGTVQLDLSKAQFHSGLYTEACFVLAEGWFEDQVFHVNAF
GFPPTEPSSTTRAYYGNINFFGGPSNTSVKTSAKLKQLEEENKDAMFVFLSDVWLDQVEV
LEKLRIMFAGYSPAPPTCFILCGNFSSAPYGKNQVQALKDSLKTLADIICEYPDIHQSSR
FVFVPGPEDPGFGSILPRPPLAESITNEFRQRVPFSVFTTNPCRIQYCTQEITVFREDLV
NKMCRNCVRFPSSNLAIPNHFVKTILSQGHLTPLPLYVCPVYWAYDYALRVYPVPDLLVI
ADKYDPFTTTNTECLCINPGSFPRSGFSFKVFYPSNKTVEDSKLQGF

# Metabolic_Enzyme_2_Number_of_Residues:
527

# Metabolic_Enzyme_2_Molecular_Weight:
59538

# Metabolic_Enzyme_2_Theoretical_pI:
6.30

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed DNA polymerase activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  DNA metabolism
Process:  DNA replication
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Participates in DNA repair and in chromosomal DNA replication

# Metabolic_Enzyme_2_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map03030  DNA polymerase

# Metabolic_Enzyme_2_Reaction:
deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF04042:DNA_pol_E_B

# Metabolic_Enzyme_2_Signals:
1-25

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.7.7.7

# Metabolic_Enzyme_2_GenBank_ID_Protein:
2697123

# Metabolic_Enzyme_2_SwissProt_ID:
DPOE2_HUMAN (P56282)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
POLE2

# Metabolic_Enzyme_2_Geneatlas_id:
POLE2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:9178

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_2_Gene_Sequence:
>1581 bp
ATGGCGCCGGAGCGGCTGCGGAGCCGGGCGCCCTCCGCCTTCAAGTTGCGGGGCTTGCTG
CTCCGTGGTGAAGCTATTAAGTACCTCACAGAAGCTCTTCAGTCTATCAGTGAATTAGAG
CTTGAAGATAAACTGGAAAAGATAATTAATGCAGTTGAGAAGCAACCCTTGTCATCAAAC
ATGATTGAACGATCTGTGGTGGAAGCAGCAGTCCAGGAATGCAGTCAGTCTGTTGATGAA
ACTATAGAGCACGTTTTCAATATCATAGGAGCATTTGATATTCCACGCTTTGTGTACAAT
TCAGAAAGAAAAAAATTTCTTCCTCTGTTAATGACCAACCACCCTGCACCAAATTTATTT
GGAACACCAAGAGATAAAGCAGAGATGTTTCGTGAGCGATATACCATTTTGCACCAGAGG
ACCCACAGGCATGAATTATTTACTCCTCCGGTGATAGGTTCTCACCCTGATGAAAGCGGA
AGCAAATTCCAGCTTAAAACAATAGAAACCTTATTGGGTAGTACAACCAAAATCGGAGAT
GCGATTGTTCTTGGAATGATAACGCAGTTAAAAGAGGGAAAATTTTTTCTGGAAGATCCT
ACTGGAACAGTCCAACTAGACCTTAGTAAAGCTCAGTTCCATAGTGGTTTATACACAGAG
GCATGCTTTGTCTTAGCAGAAGGTTGGTTTGAAGATCAAGTGTTTCATGTCAATGCCTTT
GGATTTCCACCCACTGAGCCCTCTAGTACTACTAGGGCATACTATGGAAATATTAATTTT
TTTGGAGGTCCTTCTAATACATCTGTGAAGACTTCTGCAAAACTAAAACAGCTAGAAGAG
GAGAATAAAGATGCTATGTTTGTGTTTTTATCTGATGTTTGGTTGGACCAGGTGGAAGTA
TTGGAAAAACTTCGCATAATGTTTGCTGGTTATTCACCAGCACCTCCAACCTGCTTTATT
CTGTGTGGTAATTTTTCATCTGCACCATATGGAAAAAATCAAGTTCAAGCTTTGAAAGAT
TCCCTAAAAACTTTGGCAGATATAATATGTGAATACCCAGATATTCACCAAAGTCGTTTT
GTGTTTGTACCTGGTCCAGAGGATCCTGGATTTGGTTCCATCTTACCAAGGCCACCACTT
GCTGAAAGCATCACTAATGAATTCAGACAAAGGGTACCATTTTCAGTTTTTACTACTAAT
CCTTGCAGAATTCAGTACTGTACACAGGAAATTACTGTCTTCCGTGAAGACTTAGTAAAT
AAAATGTGCAGAAACTGCGTCCGTTTTCCTAGCAGCAATTTGGCTATTCCTAATCACTTT
GTAAAGACTATCTTATCCCAAGGACATCTGACTCCCCTACCTCTTTATGTCTGCCCAGTG
TATTGGGCATATGACTATGCTTTGAGAGTGTATCCTGTGCCCGATCTACTTGTCATTGCA
GACAAATATGATCCTTTCACTACGACAAATACCGAATGCCTCTGCATAAACCCTGGCTCT
TTTCCAAGAAGTGGATTTTCATTCAAAGTTTTTTATCCTTCTAATAAGACAGTAGAAGAT
AGCAAACTTCAAGGCTTTTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF025840

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_2_Locus:
14q21-q22

# Metabolic_Enzyme_2_SNPs:
rs34574266; rs3218790; rs3218791; rs3218798; rs34281321; rs3218801; rs3218799; rs6572596; rs3218797; rs7146248; rs9671528; rs3218796; rs8009849; rs8020075; rs12432319; rs8004482; rs4898627; rs6572597; rs4900944; rs3218795; rs11157701; rs4898628; rs8003436; rs3783435; rs7146822; rs8019884; rs8003305; rs11851450; rs9635220; rs3212323; rs7147722; rs7147006; rs3218792; rs7155238; rs41415347; rs41500350; rs41355147; rs12894360; rs11157697; rs12892044; rs41327849; rs41398846; rs12232094; rs2985693; rs35222341; rs35615446; rs10220339; rs41344951; rs12437109; rs12432216; rs11157699; rs12895915; rs11157700; rs17121661; rs35930580; rs11847971; rs3218800; rs11847914; rs11848106; rs2274213; rs34000915; rs10459504; rs34857719; rs7141539; rs10633504; rs12896605; rs35130028; rs35129708; rs10220338; rs35975476; rs7157183; rs28449338; rs12432605; rs7153294; rs34118485; rs3218793; rs35764209; rs10678863; rs11357716; rs11423310; rs11620779; rs942665; rs10572392; rs35658313; rs34430638; rs12896544; rs35928004; rs35555905; rs35116175; rs35089213; rs34680659; rs41457647; rs34239544; rs12880458; rs35156256; rs35626789; rs12880793; rs34409150; rs34851030; rs35008257; rs11361567; rs12590807; rs34511706; rs35575577; rs34561679; rs34929193; rs2354455; rs35600631; rs5808510; rs11157698; rs3007038; rs35541735; rs35492711; rs35213889; rs34826484; rs34427394; rs28727279; rs34486682; rs36046648; rs12895312; rs28371875; rs11439417; rs2354456; rs35837509; rs4479141; rs35235893; rs35682205; rs34280017; rs34930369; rs12884076; rs35984833; rs35027888; rs41345247; rs8017749; rs2354454; rs35802780; rs8017401; rs2883443; rs3218794; rs10137583; rs10144216; rs10146912; rs10149544; rs11157696; rs11625706; rs12433138; rs12433192; rs12434993; rs12436414; rs17702149; rs2354449; rs2354450; rs2985684; rs2985685; rs2985686; rs2985687; rs2985688; rs3007033; rs35625814; rs35765360; rs4296170

# Metabolic_Enzyme_2_General_References:
9405441; 9443964; 11433027

# Metabolic_Enzyme_2_References:
16980562

# Metabolic_Enzyme_3_ID:
8603

# Metabolic_Enzyme_3_Name:
Maltase-glucoamylase, intestinal [Includes: Maltase

# Metabolic_Enzyme_3_Synonyms:
Alpha-glucosidase; Glucoamylase; Glucan 1,4-alpha- glucosidase]

# Metabolic_Enzyme_3_Gene_Name:
MGAM

# Metabolic_Enzyme_3_Protein_Sequence:
>Maltaseglucoamylase, intestinal Includes: Maltase
MARKKLKKFTTLEIVLSVLLLVLFIISIVLIVLLAKESLKSTAPDPGTTGTPDPGTTGTP
DPGTTGTTHA
RTTGPPDPGTTGTTPVSAECPVVNELERINCIPDQPPTKATCDQRGCCW
NPQGAVSVPWCYYSKNHSYHV
EGNLVNTNAGFTARLKNLPSSPVFGSNVDNVLLTAEYQ
TSNRFHFKLTDQTNNRFEVPHEHVQSFSGNAA
ASLTYQVEISRQPFSIKVTRRSNNRVL
FDSSIGPLLFADQFLQLSTRLPSTNVYGLGEHVHQQYRHDMNW
KTWPIFNRDTTPNGNG
TNLYGAQTFFLCLEDASGLSFGVFLMNSNAMEVVLQPAPAITYRTIGGILDFYV
FLGNT
PEQVVQEYLELIGRPALPSYWALGFHLSRYEYGTLDNMREVVERNRAAQLPYDVQHADID
YMDER
RDFTYDSVDFKGFPEFVNELHNNGQKLVIIVDPAISNNSSSSKPYGPYDRGSDM
KIWVNSSDGVTPLIGE
VWPGQTVFPDYTNPNCAVWWTKEFELFHNQVEFDGIWIDMNEV
SNFVDGSVSGCSTNNLNNPPFTPRILD
GYLFCKTLCMDAVQHWGKQYDIHNLYGYSMAV
ATAEAAKTVFPNKRSFILTRSTFAGSGKFAAHWLGDNT
ATWDDLRWSIPGVLEFNLFGI
PMVGPDICGFALDTPEELCRRWMQLGAFYPFSRNHNGQGYKDQDPASFG
ADSLLLNSSR
HYLNIRYTLLPYLYTLFFRAHSRGDTVARPLLHEFYEDNSTWDVHQQFLWGPGLLITPVL

DEGAEKVMAYVPDAVWYDYETGSQVRWRKQKVEMELPGDKIGLHLRGGYIFPTQQPNTT
TLASRKNPLGL
IIALDENKEAKGELFWDDGETKDTVANKVYLLCEFSVTQNRLEVNISQ
STYKDPNNLAFNEIKILGTEEP
SNVTVKHNGVPSQTSPTVTYDSNLKVAIITDIDLLLG
EAYTVEWSIKIRDEEKIDCYPDENGASAENCTA
RGCIWEASNSSGVPFCYFVNDLYSVS
DVQYNSHGATADISLKSSVYANAFPSTPVNPLRLDVTYHKNEML
QFKIYDPNKNRYEVP
VPLNIPSMPSSTPEGQLYDVLIKKNPFGIEIRRKSTGTIIWDSQLLGFTFSDMFI
RIST
RLPSKYLYGFGETEHRSYRRDLEWHTWGMFSRDQPPGYKKNSYGVHPYYMGLEEDGSAHG
VLLLNS
NAMDVTFQPLPALTYRTTGGVLDFYVFLGPTPELVTQQYTELIGRPVMVPYWS
LGFQLCRYGYQNDSEIA
SLYDEMVAAQIPYDVQYSDIDYMERQLDFTLSPKFAGFPALI
NRMKADGMRVILILDPAISGNETQPYPA
FTRGVEDDVFIKYPNDGDIVWGKVWPDFPDV
VVNGSLDWDSQVELYRAYVAFPDFFRNSTAKWWKREIEE
LYNNPQNPERSLKFDGMWID
MNEPSSFVNGAVSPGCRDASLNHPPYMPHLESRDRGLSSKTLCMESQQIL
PDGSLVQHY
NVHNLYGWSQTRPTYEAVQEVTGQRGVVITRSTFPSSGRWAGHWLGDNTAAWDQLKKSII
G
MMEFSLFGISYTGADICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWD
VAFVNISRTVLQ
TRYTLLPYLYTLMHKAHTEGVTVVRPLLHEFVSDQVTWDIDSQFLLG
PAFLVSPVLERNARNVTAYFPRA
RWYDYYTGVDINARGEWKTLPAPLDHINLHVRGGYI
LPWQEPALNTHLSRQKFMGFKIALDDEGTAGGWL
FWDDGQSIDTYGKGLYYLASFSASQ
NTMQSHIIFNNYITGTNPLKLGYIEIWGVGSVPVTSVSISVSGMV
ITPSFNNDPTTQVL
SIDVTDRNISLHNFTSLTWISTL

# Metabolic_Enzyme_3_Number_of_Residues:
1857

# Metabolic_Enzyme_3_Molecular_Weight:
209855

# Metabolic_Enzyme_3_Theoretical_pI:
5.14

# Metabolic_Enzyme_3_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Carbohydrate transport and metabolism

# Metabolic_Enzyme_3_Specific_Function:
May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing

# Metabolic_Enzyme_3_Pathway:
map00052  Galactose metabolism
 map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_3_Reaction:
Hydrolysis of terminal, non-reducing 1,4-linked alpha-D-glucose residues with release of alpha-D-glucose

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01055:Glyco_hydro_31
PF00088:Trefoil

# Metabolic_Enzyme_3_Signals:
1-35

# Metabolic_Enzyme_3_Transmembrane_Regions:
14-34

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.2.1.20;EC 3.2.1.3

# Metabolic_Enzyme_3_GenBank_ID_Protein:
17648144

# Metabolic_Enzyme_3_SwissProt_ID:
MGA_HUMAN (O43451)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
MGAM

# Metabolic_Enzyme_3_Geneatlas_id:
MGAM

# Metabolic_Enzyme_3_hgnc_id:
HGNC:7043

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cell membrane; apical cell membrane; single- pass type II membrane protein. Note=Brush border

# Metabolic_Enzyme_3_Gene_Sequence:
>5574 bp

ATGGCAAGAAAGAAGCTGAAAAAATTTACTACTTTGGAGATTGTGCTCAGTGTTCTTCT
GCTTGTGTTGT
TTATCATCAGTATTGTTCTAATTGTGCTTTTAGCCAAAGAGTCACTGA
AATCAACAGCCCCAGATCCTGG
GACAACTGGTACCCCAGATCCTGGGACAACTGGTACC
CCAGATCCTGGAACAACTGGTACCACACATGCT
AGGACAACGGGTCCCCCAGATCCTGG
AACAACTGGTACCACTCCTGTTTCTGCTGAATGTCCAGTGGTAA
ATGAATTGGAACGAA
TTAATTGCATCCCTGACCAGCCGCCAACAAAGGCCACATGTGACCAACGTGGCTG
TTGC
TGGAATCCCCAGGGAGCTGTAAGTGTTCCCTGGTGCTACTATTCCAAGAATCATAGCTAC
CATGTA
GAGGGCAACCTTGTCAACACAAATGCAGGATTCACAGCCCGGTTGAAAAATCT
GCCTTCTTCACCAGTGT
TTGGAAGCAATGTTGACAATGTTCTTCTCACAGCAGAATATC
AGACATCTAATCGTTTCCACTTTAAGTT
GACTGACCAAACCAATAACAGGTTTGAAGTG
CCCCACGAACACGTGCAGTCCTTCAGTGGAAATGCTGCT
GCTTCTTTGACCTACCAAGT
TGAAATCTCCAGACAGCCATTTAGCATCAAAGTGACCAGAAGAAGCAACA
ATCGTGTTT
TGTTTGACTCGAGCATTGGGCCCCTACTGTTTGCTGACCAGTTCTTGCAGCTCTCCACTC
G
ACTGCCTAGCACTAACGTGTATGGCCTGGGAGAGCATGTGCACCAGCAGTATCGGCAT
GATATGAATTGG
AAGACCTGGCCCATATTTAACAGAGACACAACTCCCAATGGAAACGG
AACTAATTTGTATGGTGCGCAGA
CATTCTTCTTGTGCCTTGAAGATGCTAGTGGATTGT
CCTTTGGGGTGTTTCTGATGAACAGCAATGCCAT
GGAGGTTGTCCTTCAGCCTGCGCCA
GCCATCACTTACCGCACCATTGGGGGCATTCTCGACTTCTATGTG
TTCTTGGGAAACAC
TCCAGAGCAAGTTGTTCAAGAATATCTAGAGCTCATTGGGCGGCCAGCCCTTCCCT
CCT
ACTGGGCGCTTGGATTTCACCTCAGTCGTTACGAATATGGAACCTTAGACAACATGAGGG
AAGTCGT
GGAGAGAAATCGCGCAGCACAGCTCCCTTATGATGTTCAGCATGCTGATATT
GATTATATGGATGAGAGA
AGGGACTTCACTTATGATTCAGTGGATTTTAAAGGCTTCCC
TGAATTTGTCAACGAGTTACACAATAATG
GACAGAAGCTTGTCATCATTGTGGATCCAG
CCATCTCCAACAACTCTTCCTCAAGTAAACCCTATGGCCC
ATATGACAGGGGTTCAGAT
ATGAAGATATGGGTGAATAGTTCAGATGGAGTGACTCCACTCATTGGGGAG
GTCTGGCC
TGGACAAACTGTGTTTCCTGATTATACCAATCCCAACTGTGCTGTTTGGTGGACAAAGGA
AT
TTGAGCTTTTTCACAATCAAGTAGAGTTTGATGGAATCTGGATTGATATGAATGAAG
TCTCCAACTTTGT
TGATGGTTCGGTCTCAGGATGTTCCACAAACAACCTAAATAATCCC
CCATTCACTCCCAGAATCCTGGAT
GGGTACCTGTTCTGCAAGACTCTCTGTATGGATGC
AGTGCAGCACTGGGGCAAGCAGTATGACATTCACA
ATCTGTATGGCTACTCCATGGCGG
TCGCCACAGCAGAAGCTGCCAAGACTGTGTTCCCTAATAAGAGAAG
CTTCATTCTGACC
CGTTCTACCTTTGCGGGCTCTGGCAAGTTTGCAGCACATTGGTTAGGAGACAACACT
GC
CACCTGGGATGACCTGAGATGGTCCATCCCTGGCGTGCTTGAGTTCAACCTTTTTGGCAT
CCCAATGG
TGGGTCCTGACATATGTGGCTTTGCTTTGGACACCCCTGAGGAGCTCTGTA
GGCGGTGGATGCAGTTGGG
TGCATTTTATCCGTTTTCTAGAAATCACAATGGCCAAGGC
TACAAGGACCAGGATCCTGCCTCCTTTGGA
GCTGACTCCCTGCTGTTGAATTCCTCCAG
GCACTACCTTAACATCCGCTATACTCTATTGCCCTACCTAT
ACACCCTTTTCTTCCGTG
CTCACAGCCGAGGGGACACGGTGGCCAGGCCCCTTTTGCATGAGTTCTACGA
GGACAAC
AGCACTTGGGATGTGCACCAACAGTTCTTATGGGGGCCCGGCCTCCTCATCACTCCAGTT
CTG
GATGAAGGTGCAGAGAAAGTGATGGCATATGTGCCTGATGCTGTCTGGTATGACTA
CGAGACTGGGAGCC
AAGTGAGATGGAGGAAGCAAAAAGTCGAGATGGAACTTCCTGGAG
ACAAAATTGGACTTCACCTTCGAGG
AGGCTACATCTTCCCCACACAGCAGCCAAATACA
ACCACTCTGGCCAGTCGAAAGAACCCTCTTGGTCTT
ATCATTGCCCTAGATGAGAACAA
AGAAGCAAAAGGAGAACTTTTCTGGGATGATGGGGAAACGAAGGATA
CTGTGGCCAATA
AAGTGTATCTTTTATGTGAGTTTTCTGTCACTCAAAACCGCTTGGAGGTGAATATTTC
A
CAATCAACCTACAAGGACCCCAATAATTTAGCATTTAATGAGATTAAAATTCTTGGGACG
GAGGAACCT
AGCAATGTTACAGTGAAACACAATGGTGTCCCAAGTCAGACTTCTCCTAC
AGTCACTTATGATTCTAACC
TGAAGGTTGCCATTATCACAGATATTGATCTTCTCCTGG
GAGAAGCATACACAGTGGAATGGAGCATAAA
GATAAGGGATGAAGAAAAAATAGACTGT
TACCCTGATGAGAATGGTGCTTCTGCCGAAAACTGCACTGCC
CGTGGCTGTATCTGGGA
GGCATCCAATTCTTCTGGAGTCCCTTTTTGCTATTTTGTCAACGACCTATACT
CTGTCA
GTGATGTTCAGTATAATTCCCATGGGGCCACAGCTGACATCTCCTTAAAGTCTTCCGTTT
ATGC
CAATGCCTTCCCCTCCACACCCGTGAACCCCCTTCGCCTGGATGTCACTTACCAT
AAGAATGAAATGCTG
CAGTTCAAGATTTATGATCCCAACAAGAATCGGTATGAAGTTCC
AGTCCCTCTGAACATACCCAGCATGC
CATCCAGCACCCCTGAGGGTCAACTCTATGATG
TGCTCATTAAGAAGAATCCATTTGGGATTGAAATTCG
CCGGAAGAGTACAGGCACTATA
ATTTGGGACTCTCAGCTCCTTGGCTTTACCTTCAGTGACATGTTTATC
CGCATCTCCAC
CCGCCTTCCCTCCAAGTACCTCTATGGCTTTGGGGAAACTGAGCACAGGTCCTATAGGA
GAGACTTGGAGTGGCACACTTGGGGGATGTTCTCCCGAGACCAGCCCCCAGGGTACAAGA
AGAATTCCTA
TGGTGTCCACCCCTACTACATGGGGCTGGAGGAGGACGGCAGTGCCCAT
GGAGTGCTCCTGCTGAACAGC
AATGCCATGGATGTGACGTTCCAGCCCCTGCCTGCCTT
GACATACCGCACCACAGGGGGAGTTCTGGACT
TTTATGTGTTCTTGGGGCCGACTCCAG
AGCTTGTCACCCAGCAGTACACTGAGTTGATTGGCCGGCCTGT
GATGGTACCTTACTGG
TCTTTGGGGTTCCAGCTGTGTCGCTATGGCTACCAGAATGACTCTGAGATCGCC
AGCTT
GTATGATGAGATGGTGGCTGCCCAGATCCCTTATGATGTGCAGTACTCAGACATCGACTA
CATGG
AGCGGCAGCTGGACTTCACCCTCAGCCCCAAGTTTGCTGGGTTTCCAGCTCTGA
TCAATCGCATGAAGGC
TGATGGGATGCGGGTCATCCTCATTCTGGATCCAGCCATTTCT
GGCAATGAGACACAGCCTTATCCTGCC
TTCACTCGGGGCGTGGAGGATGACGTCTTCAT
CAAATACCCAAATGATGGAGACATTGTCTGGGGAAAGG
TCTGGCCTGATTTTCCTGATG
TTGTTGTGAATGGGTCTCTAGACTGGGACAGCCAAGTGGAGCTATATCG
AGCTTATGTG
GCCTTCCCAGACTTTTTCCGTAATTCAACTGCCAAGTGGTGGAAGAGGGAAATAGAAGAA

CTATACAACAATCCACAGAATCCAGAGAGGAGCTTGAAGTTTGATGGCATGTGGATTGA
TATGAATGAAC
CATCAAGCTTCGTGAATGGGGCAGTTTCTCCAGGCTGCAGGGACGCCT
CTCTGAACCACCCTCCCTACAT
GCCACATTTGGAGTCCAGGGACAGGGGCCTGAGCAGC
AAGACCCTTTGTATGGAGAGTCAGCAGATCCTC
CCAGACGGCTCCCTGGTGCAGCACTA
CAACGTGCACAACCTGTATGGGTGGTCCCAGACCAGACCCACAT
ACGAAGCCGTGCAGG
AGGTGACGGGACAGCGAGGGGTCGTCATCACCCGCTCCACATTTCCCTCTTCTGG
CCGC
TGGGCAGGACATTGGCTGGGAGACAACACGGCCGCATGGGATCAGCTGAAGAAGTCTATC
ATTGGC
ATGATGGAGTTCAGCCTCTTCGGCATATCCTATACGGGAGCAGATATCTGTGG
GTTCTTTCAAGATGCTG
AATATGAGATGTGTGTTCGCTGGATGCAGCTGGGGGCCTTTT
ACCCCTTCTCAAGAAACCACAACACCAT
TGGGACCAGGAGACAAGACCCTGTGTCCTGG
GATGTTGCTTTTGTGAATATTTCCAGAACTGTCCTGCAG
ACCAGATACACCCTGTTGCC
ATATCTGTATACCTTGATGCATAAGGCCCACACGGAGGGCGTCACTGTTG
TGCGGCCTC
TGCTCCATGAATTTGTGTCAGACCAGGTGACATGGGACATAGACAGTCAGTTCCTGCTGG
G
CCCAGCCTTCCTGGTCAGCCCTGTCCTGGAGCGTAATGCCAGAAATGTCACTGCATAT
TTCCCTAGAGCC
CGCTGGTATGATTACTACACGGGTGTGGATATTAATGCAAGAGGAGA
GTGGAAGACCTTGCCAGCCCCTC
TTGACCACATTAATCTTCATGTCCGTGGGGGCTACA
TCCTGCCCTGGCAAGAGCCTGCACTGAACACCCA
CTTAAGCCGCCAGAAATTCATGGGC
TTCAAAATTGCCTTGGATGATGAAGGAACTGCTGGGGGCTGGCTC
TTCTGGGATGATGG
GCAAAGCATTGATACCTATGGGAAAGGACTCTATTACTTGGCCAGCTTTTCTGCCA
GCC
AGAATACGATGCAAAGCCATATAATTTTCAACAATTACATCACTGGTACAAATCCTTTGA
AACTGGG
CTACATTGAAATCTGGGGAGTGGGCAGTGTCCCCGTTACCAGTGTCAGCATC
TCTGTGAGTGGCATGGTC
ATAACACCCTCCTTCAACAATGACCCCACGACACAGGTATT
AAGCATCGATGTGACTGACAGAAACATCA
GCCTACATAATTTTACTTCATTGACGTGGA
TAAGCACTCTGTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
AF016833

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_3_Locus:
7q34

# Metabolic_Enzyme_3_SNPs:
rs2272330; rs2960746; rs9655651; rs2961085; rs10255702; rs2960758; rs6975672; rs7785793; rs7781962; rs7785785; rs1285938; rs1554779; rs1285943; rs2014744; rs2916189; rs2950415; rs6974784; rs1285939; rs1294353; rs1285942; rs1285940; rs1285941; rs9986889; rs1315501; rs1285963; rs2204607; rs1358305; rs1880924; rs1298582; rs3793158; rs4416750; rs7797443; rs4725564; rs2272329; rs4236462; rs6464459; rs6972387; rs10464448; rs1285964; rs2961075; rs4132774; rs4607527; rs6979075; rs2960744; rs4509233; rs6946799; rs10271514; rs6464455; rs4283959; rs4401759; rs1465093; rs7809134; rs4492290; rs11762139; rs1285965; rs6464456; rs7793854; rs4311588; rs1527308; rs2961084; rs4259331; rs6973762; rs4726487; rs10248676; rs2272327; rs10275642; rs6959526; rs11764581; rs6952930; rs12666982; rs1527304; rs2961093; rs6464460; rs6948116; rs10267188; rs7797360; rs3800992; rs2961072; rs2960747; rs6971536; rs6972399; rs1358304; rs10265585; rs4374898; rs10263152; rs10251374; rs4726489; rs2961089; rs6972071; rs10238188; rs10952514; rs2960741; rs17162645; rs4481500; rs2961071; rs10259614; rs10274953; rs10232224; rs11982668; rs10269898; rs6963697; rs4295577; rs10270832; rs2960757; rs11761379; rs4725565; rs7785237; rs1527307; rs6956284; rs12535134; rs6942712; rs2961088; rs3800993; rs17635392; rs6966500; rs6945268; rs2960753; rs10225000; rs2272332; rs12540186; rs4336523; rs6955265; rs10263497; rs7810984; rs4329195; rs2961070; rs10282125; rs4341081; rs6977302; rs10274727; rs10243909; rs10266961; rs4281037; rs7777521; rs6464457; rs10952513; rs2961079; rs10237480; rs6955801; rs10259179; rs6464458; rs4341082; rs10234559; rs11772559; rs7801101; rs3936103; rs6945098; rs10269972; rs4434539; rs7807614; rs6973212; rs13235026; rs2960745; rs2961086; rs4466313; rs10271524; rs4077884; rs11763459; rs4467860; rs10247389; rs4276595; rs11972048; rs10952515; rs10215074; rs4374899; rs10250021; rs10269815; rs13245455; rs4726488; rs7797154; rs10259247; rs12703416; rs4285406; rs10215397; rs2272333; rs4236463; rs8180874; rs4470936; rs10259861; rs10274045; rs12535693; rs11977977; rs2960749; rs11984387; rs11767883; rs12703419; rs7807635; rs4478492; rs10262878; rs3793160; rs10246711; rs10258756; rs11979847; rs10259080; rs10952512; rs6971200; rs10228658; rs11976181; rs1852508; rs10227984; rs10244346; rs12535150; rs2960748; rs13246665; rs10260661; rs3922664; rs7801560; rs10233312; rs10270252; rs4072660; rs7788669; rs4445145; rs10268987; rs12703420; rs10228285; rs10279559; rs4323398; rs2961073; rs7778384; rs10215743; rs6948269; rs12534166; rs10282365; rs3793159; rs4439034; rs2272331; rs7811738; rs6976953; rs10224348; rs6959585; rs1554778; rs1985729; rs1609100; rs17523282; rs17523275; rs12534052; rs13437780; rs3087318; rs3024261; rs10266732; rs2961087; rs3087316; rs3087313; rs3087312; rs3087321; rs2272326; rs3087320; rs3087317; rs2961078; rs2960743; rs2960736; rs2961074; rs3087319; rs2960742; rs34857144; rs35653081; rs28514687; rs10226939; rs34760774; rs12703415; rs5888024; rs35669493; rs3793155; rs35920360; rs34459807; rs1285966; rs10237141; rs35788986; rs34895109; rs11983493; rs10247082; rs12703421; rs10244325; rs28423084; rs4281038; rs12703417; rs10273420; rs35749361; rs10248818; rs11520861; rs28510141; rs10241636; rs10282275; rs35847864; rs7797111; rs10237351; rs10250665; rs35268349; rs11461388; rs35480595; rs13309020; rs12333515; rs34430579; rs6979151; rs7812190; rs2960756; rs1527306; rs10667629; rs2961068; rs7458999; rs10258491; rs34192955; rs2961091; rs2961090; rs2961050; rs2960738; rs35988825; rs28537610; rs6959057; rs34813545; rs34977568; rs35537649; rs34188746; rs4305809; rs28469296; rs2961080; rs35712953; rs10215393; rs5888027; rs35959513; rs28437665; rs2960752; rs11298938; rs10278406; rs12534614; rs13247647; rs5018142; rs10256983; rs35461005; rs6975959; rs28716240; rs4577878; rs34723275; rs13244181; rs7779914; rs28581545; rs10276356; rs11387547; rs11380053; rs34657431; rs10215476; rs7811050; rs4518576; rs4507684; rs28412172; rs35949770; rs10238608; rs4072659; rs10580224; rs4395805; rs13309153; rs35944134; rs34615965; rs13221059; rs4559156; rs28645759; rs11974543; rs13311070; rs28379279; rs28674598; rs34336582; rs11771350; rs35891390; rs34641123; rs5888030; rs35278052; rs5018141; rs12154542; rs36061384; rs10259742; rs10215116; rs28497852; rs13310650; rs6957100; rs2960739; rs7794785; rs6958744; rs13309184; rs35142877; rs34914843; rs35038034; rs35345914; rs10259159; rs10244836; rs2960740; rs2961051; rs34541464; rs10243556; rs28628756; rs10248179; rs13308609; rs1159908; rs10260094; rs35054393; rs13310356; rs3087323; rs35315198; rs2961077; rs6943118; rs4276597; rs4236465; rs10231300; rs34951844; rs7800808; rs35767682; rs12531274; rs4725566; rs2960750; rs34025802; rs2960754; rs6950286; rs5888026; rs5888025; rs34471297; rs28477143; rs4344010; rs10250427; rs7777496; rs10273141; rs35884991; rs3923516; rs28570409; rs35116200; rs34441915; rs4410826; rs10249175; rs11560310; rs13310467; rs35584918; rs28712440; rs2961082; rs13310343; rs2960759; rs34189651; rs10267379; rs7781119; rs10280322; rs10276588; rs35219643; rs12155113; rs10693852; rs35289418; rs28586906; rs2950416; rs36052135; rs34100990; rs7357303; rs10282020; rs35169560; rs35184064; rs3087322; rs7458091; rs6959679; rs6150373; rs35295955; rs7785722; rs28566864; rs2960755; rs4236464; rs34011006; rs2961083; rs35030661; rs4310117; rs34912666; rs4725567; rs13309170; rs2960751; rs28469053; rs11380054; rs35627220; rs2272328; rs7793931; rs1918300; rs13310649; rs34810980; rs34827622; rs34524738; rs4397311; rs13310468; rs35280330; rs10257488; rs4072658; rs28446896; rs2960737; rs34828733; rs2961076; rs13310136; rs10262981; rs4276596; rs10258954; rs10271669; rs12155112; rs11289169; rs10667628; rs34618129; rs12334002; rs35425766; rs9768807; rs2068065; rs10601773; rs2961069; rs11452654; rs35626773; rs13310352; rs10234045; rs941254; rs1527305; rs13234464; rs34993763; rs34385353; rs35513186; rs34254997; rs28476688; rs2961092; rs13310384; rs7785703; rs28559920; rs5888028; rs11770427; rs10710111; rs10229158; rs34917609; rs35381053; rs35957939; rs10225228; rs10234068; rs10246387; rs10273892; rs10952516; rs12703414; rs1294351; rs1298999; rs4288283; rs4324856; rs4407790; rs4428591; rs4593441; rs4632974; rs4725568; rs4726484; rs6947481; rs6951223; rs6951410

# Metabolic_Enzyme_3_General_References:
9446624; 3143729; 3121301

# Metabolic_Enzyme_3_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7010

# Macromolecular_Interacting_Partner_1_Name:
Proactivator polypeptide precursor [Contains: Saposin A

# Macromolecular_Interacting_Partner_1_Synonyms:
Protein A; Saposin B-Val; Saposin B; Sphingolipid activator protein 1; SAP-1; Cerebroside sulfate activator; CSAct; Dispersin; Sulfatide/GM1 activator; Saposin C; Co-beta-glucosidase; A1 activator; Glucosylceramidase activator; Sphingolipid activator protein 2; SAP-2; Saposin D; Protein C; Component C]

# Macromolecular_Interacting_Partner_1_Gene_Name:
PSAP

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Proactivator polypeptide precursor Contains: Saposin 
AMYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVK
SLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILD
IIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLL
YPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMAD
ICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELV
EPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQE
VVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYL
DRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKI
GACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
524

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
58113

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
4.82

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  sphingolipid metabolism
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  vacuole
Component:  lytic vacuole
Component:  lysosome

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Saposin D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12)

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF02199:SapA;
PF05184:SapB_1;
PF03489:SapB_2

# Macromolecular_Interacting_Partner_1_Signals:
1-16

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
220064

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
SAP_HUMAN (P07602)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
PSAP

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
PSAP

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9498

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Lysosome

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1584 bp
ATGTACGCCCTCTTCCTCCTGGCCAGCCTCCTGGGCGCGGCTCTAGCCGGCCCGGTCCTT
GGACTGAAAGAATGCACCAGGGGCTCGGCAGTGTGGTGCCAGAATGTGAAGACGGCGTCC
GACTGCGGGGCAGTGAAGCACTGCCTGCAGACCGTTTGGAACAAGCCAACAGTGAAATCC
CTTCCCTGCGACATATGCAAAGACGTTGTCACCGCAGCTGGTGATATGCTGAAGGACAAT
GCCACTGAGGAGGAGATCCTTGTTTACTTGGAGAAGACCTGTGACTGGCTTCCGAAACCG
AACATGTCTGCTTCATGCAAGGAGATAGTGGACTCCTACCTCCCTGTCATCCTGGACATC
ATTAAAGGAGAAATGAGCCGTCCTGGGGAGGTGTGCTCTGCTCTCAACCTCTGCGAGTCT
CTCCAGAAGCACCTAGCAGAGCTGAATCACCAGAAGCAGCTGGAGTCCAATAAGATCCCA
GAGCTGGACATGACTGAGGTGGTGGCCCCCTTCATGGCCAACATCCCTCTCCTCCTCTAC
CCTCAGGACGGCCCCCGCAGCAAGCCCCAGCCAAAGGATAATGGGGACGTTTGCCAGGAC
TGCATTCAGATGGTGACTGACATCCAGACTGCTGTACGGACCAACTCCACCTTTGTCCAG
GCCTTGGTGGAACATGTCAAGGAGGAGTGTGACCGCCTGGGCCCTGGCATGGCCGACATA
TGCAAGAACTATATCAGCCAGTATTCTGAAATTGCTATCCAGATGATGATGCACATGCAG
GATCAGCAACCCAAGGAGATCTGTGCGCTGGTTGGGTTCTGTGATGAGGTGAAAGAGATG
CCCATGCAGACTCTGGTCCCCGCCAAAGTGGCCTCCAAGAATGTCATCCCTGCCCTGGAA
CTGGTGGAGCCCATTAAGAAGCACGAGGTCCCAGCAAAGTCTGATGTTTACTGTGAGGTG
TGTGAATTCCTGGTGAAGGAGGTGACCAAGCTGATTGACAACAACAAGACTGAGAAAGAA
ATACTCGACGCTTTTGACAAAATGTGCTCGAAGCTGCCGAAGTCCCTGTCGGAAGAGTGC
CAGGAGGTGGTGGACACGTACGGCAGCTCCATCCTGTCCATCCTGCTGGAGGAGGTCAGC
CCTGAGCTGGTGTGCAGCATGCTGCACCTCTGCTCTGGCACGCGGCTGCCTGCACTGACC
GTTCACGTGACTCAGCCAAAGGACGGTGGCTTCTGCGAAGTGTGCAAGAAGCTGGTGGGT
TATTTGGATCGCAACCTGGAGAAAAACAGCACCAAGCAGGAGATCCTGGCTGCTCTTGAG
AAAGGCTGCAGCTTCCTGCCAGACCCTTACCAGAAGCAGTGTGATCAGTTTGTGGCAGAG
TACGAGCCCGTGCTGATCGAGATCCTGGTGGAGGTGATGGATCCTTCCTTCGTGTGCTTG
AAAATTGGAGCCTGCCCCTCGGCCCATAAGCCCTTGTTGGGAACTGAGAAGTGTATATGG
GGCCCAAGCTACTGGTGCCAGAACACAGAGACAGCAGCCCAGTGCAATGCTGTCGAGCAT
TGCAAACGCCATGTGTGGAACTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
D00422

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_1_Locus:
10q21-q22

# Macromolecular_Interacting_Partner_1_SNPs:
rs2070188; rs7869; rs1055754; rs2394846; rs762571; rs1015193; rs4237331; rs720295; rs7899959; rs7905774; rs7922255; rs885828; rs4237332; rs4747202; rs4747206; rs2070968; rs2394845; rs4747207; rs1900498; rs7350390; rs728289; rs2394844; rs6480560; rs9663508; rs2593163; rs749823; rs3747860; rs6480561; rs3819341; rs6480559; rs11000017; rs10740391; rs727414; rs2249814; rs2121535; rs7912803; rs2854986; rs7093252; rs10823852; rs3747855; rs11000020; rs16929408; rs11598989; rs11596365; rs4747203; rs12413995; rs10762483; rs4747204; rs4747208; rs11000016; rs12414356; rs2854992; rs11000025; rs727415; rs4747205; rs2166630; rs16913438; rs10762484; rs2854987; rs1900499; rs4454640; rs7917605; rs11000018; rs12413014; rs4746095; rs10762482; rs12415202; rs762573; rs12769743; rs1811087; rs2290023; rs7918049; rs11813373; rs9665661; rs11592448; rs9415055; rs11591470; rs7916568; rs7917015; rs11818931; rs2394843; rs11000019; rs4747209; rs7898293; rs4747210; rs11598617; rs9299509; rs9299510; rs12261323; rs1803650; rs11555015; rs11555016; rs11555021; rs11555017; rs1049882; rs1056711; rs1054851; rs1054293; rs11555018; rs41282246; rs11555020; rs36076120; rs14595; rs1053333; rs12844; rs28365839; rs1803651; rs2121536; rs7090110; rs11596605; rs35320964; rs34332602; rs2593164; rs11000024; rs7091271; rs9416009; rs2854984; rs5786051; rs34551152; rs11415214; rs2593162; rs5786050; rs959189; rs7898921; rs1894270; rs8181334; rs7477139; rs35814383; rs36035697; rs11595017; rs1867981; rs12266725; rs9416010; rs7072424; rs2854990; rs7098225; rs11277133; rs35027678; rs12220614; rs5786049; rs11000023; rs28535035; rs12571681; rs35131935; rs12247334; rs34701833; rs9415054; rs12782637; rs12252719; rs41307569; rs7922360; rs2854989; rs7911004; rs11285654; rs3061818; rs2593161; rs11000026; rs2854985; rs2854991; rs11305283; rs7899796; rs34761785; rs7072021; rs11000021; rs12247599; rs2854988; rs7076038; rs5007340; rs10566090; rs2305203; rs41306532; rs3891337; rs762572; rs5007339; rs10566091; rs2593160; rs3878001; rs35837949; rs7068078; rs35439306; rs12217799; rs35407936; rs34509443; rs35534537; rs2121537; rs35068924; rs11598625; rs34150455; rs28365838; rs7897854; rs34228343; rs10390; rs1054635; rs10762485; rs11000030; rs12252818; rs12416292; rs12774485; rs13377076; rs16929375; rs16929427; rs1867978; rs1992823; rs2290021; rs2290022; rs2394840; rs3802707; rs4746097; rs4747197; rs4747198; rs4747199; rs6480562; rs7085713; rs7092990; rs9415051; rs9415053

# Macromolecular_Interacting_Partner_1_General_References:
2515150; 2498298; 2842863; 1612590; 8323276; 1958198; 2013321; 2717620; 8370464; 2825202; 2868718; 3242555; 2209618; 3442600; 2845979; 3048308; 10562467; 7730378; 11180632; 10406958; 12510003; 10510427; 12518053; 7866401; 2302219; 2320574; 2019586; 2060627

# Macromolecular_Interacting_Partner_1_References:
11248102; 11248118; 16413768

# Macromolecular_Interacting_Partner_2_ID:
6105

# Macromolecular_Interacting_Partner_2_Name:
Glutathione S-transferase A2

# Macromolecular_Interacting_Partner_2_Synonyms:
GTH2; HA subunit 2; GST- gamma; GSTA2-2; GST class-alpha member 2

# Macromolecular_Interacting_Partner_2_Gene_Name:
GSTA2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Glutathione Stransferase A2
MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKEKALIDMYIEGIADLGEMILLLPFSQPEEQDAK
LALIQEKTKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEESRKIFRF

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
222

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
25664

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
9.07

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  glutathione transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

# Macromolecular_Interacting_Partner_2_Pathway:
map00480  Glutathione metabolism

# Macromolecular_Interacting_Partner_2_Reaction:
RX + glutathione = HX + R-S-glutathione

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
EC 2.5.1.18

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
306811

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
GSTA2_HUMAN (P09210)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
GSTA2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
GSTA2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:4627

# Macromolecular_Interacting_Partner_2_PDB_ID:
1AGS

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>669 bp
ATGGCAGAGAAGCCCAAGCTCCACTACTCCAATATACGGGGCAGAATGGAGTCCATCCGG
TGGCTCCTGGCTGCAGCTGGAGTAGAGTTTGAAGAGAAATTTATAAAATCTGCAGAAGAT
TTGGACAAGTTAAGAAATGATGGATATTTGATGTTCCAGCAAGTGCCAATGGTTGAGATT
GATGGGATGAAGCTGGTGCAGACCAGAGCCATTCTCAACTACATTGCCAGCAAATACAAC
CTCTATGGGAAAGACATAAAGGAGAAAGCCCTGATTGATATGTATATAGAAGGTATAGCA
GATTTGGGTGAAATGATCCTTCTTCTGCCCTTTACTCAACCTGAGGAACAAGATGCCAAG
CTTGCCTTGATCCAAGAGAAAACAAAAAATCGCTACTTCCCTGCCTTTGAAAAAGTCTTA
AAGAGCCACGGACAAGACTACCTTGTTGGCAACAAGCTGAGCCGGGCTGACATTCACCTG
GTGGAACTTCTCTACTACGTGGAAGAGCTTGACTCTAGCCTTATTTCCAGCTTCCCTCTG
CTGAAGGCCCTGAAAACCAGAATCAGTAACCTGCCCACAGTGAAGAAGTTTCTACAGCCT
GGCAGCCCAAGGAAGCCTCCCATGGATGAGAAATCTTTAGAAGAATCAAGGAAGATTTTC
AGGTTTTAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M16594

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_2_Locus:
6p12.1

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
3036131; 1329668; 1497629; 14574404; 8431482; 2604726; 11668220

# Macromolecular_Interacting_Partner_2_References:
11162391; 11391022; 12609537; 12729732

# Macromolecular_Interacting_Partner_3_ID:
7803

# Macromolecular_Interacting_Partner_3_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_3_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_3_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_3_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_3_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_3_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_3_SNPs:
Not Available

# Macromolecular_Interacting_Partner_3_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_3_References:
11171984; 12225853; 15136159; 16326809

# Macromolecular_Interacting_Partner_4_ID:
7863

# Macromolecular_Interacting_Partner_4_Name:
Coagulation factor X precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
Stuart factor; Stuart- Prower factor[Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]

# Macromolecular_Interacting_Partner_4_Gene_Name:
F10

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Coagulation factor X precursor
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
488

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
54732

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
5.74

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
Process:  physiological process
Process:  organismal physiological process
Process:  regulation of body fluids
Process:  hemostasis
Process:  blood coagulation
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00008:EGF;
PF00594:Gla;
PF00089:Trypsin

# Macromolecular_Interacting_Partner_4_Signals:
1-31

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
EC 3.4.21.6

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
182841

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
FA10_HUMAN (P00742)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
F10

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
F10

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:3528

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1433 bp
CCTCCCTGGCTGGCCTCCTGCTGCTCGGGGAAAGTCTGTTCATCCGCAGGGAGCAGGCCA
ACAACATCCTGGCGAGGGTCACGAGGGCCAATTCCTTTCTTGAAGAGATGAAGAAAGGAC
ACCTCGAAAGAGAGTGCATGGAAGAGACCTGCTCATACGAAGAGGCCCGCGAGGTCTTTG
AGGACAGCGACAAGACGAATGAATTCTGGAATAAATACAAAGATGGCGACCAGTGTGAGA
CCAGTCCTTGCCAGAACCAGGGCAAATGTAAAGACGGCCTCGGGGAATACACCTGCACCT
GTTTAGAAGGATTCGAAGGCAAAAACTGTGAATTATTCACACGGAAGCTCTGCAGCCTGG
ACAACGGGGACTGTGACCAGTTCTGCCACGAGGAACAGAACTCTGTGGTGTGCTCCTGCG
CCCGCGGGTACACCCTGGCTGACAACGGCAAGGCCTGCATTCCCACAGGGCCCTACCCCT
GTGGGAAACAGACCCTGGAACGCAGGAAGAGGTCAGTGGCCCAGGCCACCAGCAGCAGCG
GGGAGGCCCCTGACAGCATCACATGGAAGCCATATGATGCAGCCGACCTGGACCCCACCG
AGAACCCCTTCGACCTGCTTGACTTCAACCAGACGCAGCCTGAGAGGGGCGACAACAACC
TCACCAGGATCGTGGGAGGCCAGGAATGCAAGGACGGGGAGTGTCCCTGGCAGGCCCTGC
TCATCAATGAGGAAAACGAGGGTTTCTGTGGTGGAACTATTCTGAGCGAGTTCTACATCC
TAACGGCAGCCCACTGTCTCTACCAAGCCAAGAGATTCAAGGTGAGGGTAGGGGACCGGA
ACACGGAGCAGGAGGAGGGCGGTGAGGCGGTGCACGAGGTGGAGGTGGTCATCAAGCACA
ACCGGTTCACAAAGGAGACCTATGACTTCGACATCGCCGTGCTCCGGCTCAAGACCCCCA
TCACCTTCCGCATGAACGTGGCGCCTGCCTGCCTCCCCGAGCGTGACTGGGCCGAGTCCA
CGCTGATGACGCAGAAGACGGGGATTGTGAGCGGCTTCGGGCGCACCCACGAGAAGGGCC
GGCAGTCCACCAGGCTCAAGATGCTGGAGGTGCCCTACGTGGACCGCAACAGCTGCAAGC
TGTCCAGCAGCTTCATCATCACCCAGAACATGTTCTGTGCCGGCTACGACACCAAGCAGG
AGGATGCCTGCCAGGGGGACAGCGGGGGCCCGCACGTCACCCGCTTCAAGGACACCTACT
TCGTGACAGGCATCGTCAGCTGGGGAGAGAGCTGTGCCCGTAAGGGGAAGTACGGGATCT
ACACCAAGGTCACCGCCTTCCTCAAGTGGATCGACAGGTCCATGAAAACCAGGGGCTTGC
CCAAGGCCAAGAGCCATGCCCCGGAGGTCATAACGTCCTCTCCATTAAAGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
K03194

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:13

# Macromolecular_Interacting_Partner_4_Locus:
13q34

# Macromolecular_Interacting_Partner_4_SNPs:
rs5961; rs5963; rs3211783; rs3211772; rs5960; rs5962; rs3212994; rs3211764; rs556694; rs473598; rs528218; rs3211736; rs693335; rs3211719; rs474810; rs2251102; rs483743; rs2026160; rs547138; rs483949; rs3211727; rs559054; rs3211721; rs6577029; rs776906; rs3211780; rs3211744; rs2480946; rs3211797; rs2031184; rs3213001; rs3211761; rs3211723; rs3212998; rs3211728; rs6577028; rs3211765; rs3211757; rs3211742; rs3211720; rs3211750; rs572772; rs776897; rs3211795; rs3211729; rs776905; rs473950; rs3211792; rs3213005; rs553474; rs776900; rs3211784; rs3211756; rs3211782; rs3211752; rs9577467; rs11618833; rs3212996; rs3213007; rs3211770; rs513101; rs3211730; rs753057; rs3211746; rs3211794; rs3211768; rs3211779; rs3213004; rs9549675; rs3211773; rs485798; rs3211755; rs3211790; rs7337258; rs9577468; rs3213000; rs12871886; rs558542; rs3212997; rs2480945; rs3211789; rs3211800; rs3211793; rs7319750; rs3211798; rs3093261; rs11841132; rs511446; rs3212991; rs482020; rs3211803; rs3093260; rs474671; rs563064; rs3093268; rs3211712; rs3829390; rs3211717; rs3211715; rs3212990; rs3211714; rs3212992; rs563964; rs1803564; rs5959; rs41286610; rs3211718; rs35387691; rs3212999; rs3211748; rs3211735; rs4907591; rs499939; rs28673547; rs5806974; rs11398393; rs35189037; rs1885953; rs7489626; rs9604029; rs10672302; rs3211733; rs12872564; rs3211788; rs9604026; rs3211786; rs3211777; rs9604030; rs3211781; rs3211775; rs3211751; rs1967771; rs9972067; rs3211802; rs3213003; rs9604032; rs5806975; rs35054262; rs9549676; rs7489867; rs34684998; rs11302446; rs3211745; rs3213006; rs3211722; rs3211737; rs4907592; rs9604028; rs3212995; rs3838839; rs5806973; rs3211732; rs3211763; rs34977706; rs3829391; rs9604031; rs3211747; rs35421056; rs34353263; rs9577466; rs35707873; rs9604027; rs7985398; rs34144550; rs3211787; rs776898; rs3211760; rs35682307; rs9577469; rs3211778; rs3211734; rs3211759; rs3211771; rs34440130; rs1178282; rs5958; rs3213002; rs3211785; rs41286608; rs3211769; rs3211801; rs3211708; rs34034328; rs34246545; rs35846940; rs3211710; rs3212993; rs10482845; rs11618399; rs12232033; rs1755684; rs1885956; rs2273971; rs2760564; rs2774011; rs3024699; rs3024700; rs3024704; rs3024707; rs3024708; rs3024709; rs3024710; rs3024711; rs3024716; rs3024717; rs3093244; rs3093245; rs3093246; rs3093247; rs3093248; rs3093253; rs3093255; rs3093256; rs3093257; rs3093258; rs3093259; rs3093266; rs34306925; rs34946892; rs488703; rs491098; rs493833; rs569557; rs571149; rs6040; rs6041; rs6042; rs6043; rs6044; rs6045; rs6046; rs7320940; rs7335409

# Macromolecular_Interacting_Partner_4_General_References:
1902434; 3768336; 2582420; 3011603; 6871167; 6587384; 8243461; 2612918; 8355279; 9618463; 10391209

# Macromolecular_Interacting_Partner_4_References:
10906770; 11063508; 11123337; 11392485

# Macromolecular_Interacting_Partner_5_ID:
7823

# Macromolecular_Interacting_Partner_5_Name:
Thioredoxin

# Macromolecular_Interacting_Partner_5_Synonyms:
Trx; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP

# Macromolecular_Interacting_Partner_5_Gene_Name:
TXN

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Thioredoxin
MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVD
DCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
105

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
11738

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
4.55

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  transporter activity
Function:  electron transporter activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Macromolecular_Interacting_Partner_5_Specific_Function:
ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55)

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00085:Thioredoxin

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
825724

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
THIO_HUMAN (P10599)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
TXN

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
TXN

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:12435

# Macromolecular_Interacting_Partner_5_PDB_ID:
1ERU

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>24 bp
ATGGTGAAGCAGATCGAGAGCAAG

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
X54539

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_5_Locus:
9q31

# Macromolecular_Interacting_Partner_5_SNPs:
rs1049927; rs5843; rs1410051; rs997392; rs2418076; rs1964889; rs4135208; rs4135211; rs4135188; rs4135203; rs4135192; rs2031760; rs4135172; rs4135204; rs4135185; rs4135180; rs4135221; rs4135178; rs4135165; rs4135174; rs1344428; rs4135168; rs4135218; rs4135159; rs4135190; rs4135225; rs4135183; rs2031761; rs4135220; rs4135163; rs4135182; rs4135212; rs4135173; rs4135213; rs4135158; rs4135198; rs4135191; rs10980288; rs4135226; rs4135170; rs4135184; rs4135189; rs4135222; rs4135214; rs10816952; rs7864667; rs4135179; rs4135164; rs4135223; rs4135167; rs4135162; rs4135171; rs4135219; rs4135187; rs4135215; rs4135161; rs4135207; rs4135200; rs4135176; rs4135186; rs4135166; rs4135181; rs2776; rs2026313; rs749385; rs4135233; rs3808888; rs2026314; rs4135152; rs749384; rs2301241; rs2301242; rs4135153; rs2301243; rs4135157; rs2026312; rs4135154; rs4135227; rs4135231; rs2301244; rs7041105; rs10980283; rs3983454; rs34541971; rs4135230; rs12047; rs4135201; rs10980284; rs727495; rs12337227; rs33999867; rs3925900; rs28645612; rs10980287; rs35411291; rs4135195; rs36078214; rs4135202; rs4135160; rs7040644; rs4135194; rs4135199; rs4135209; rs4135169; rs10980286; rs5899890; rs4135196; rs4135206; rs4135175; rs5899889; rs4135224; rs35379458; rs12345107; rs4135216; rs41439150; rs4135205; rs4135193; rs33994906; rs34871717; rs10980285; rs11789920; rs5899888; rs34249598; rs4135197; rs4135177; rs4135217; rs4135210; rs36006358; rs3063988; rs35754176; rs34607508; rs4135151; rs4135155; rs35571461; rs5899887; rs35949798; rs7040982; rs4135156; rs2026315; rs4135229; rs12237768; rs2301245; rs4135228; rs34888282; rs11555799; rs4135232; rs10117222; rs10733576; rs10739292; rs10759402; rs10759403; rs10980282; rs10980289; rs10980290; rs12001418; rs12004901; rs12683470; rs12686813; rs3758192; rs7020757; rs7035393; rs7037365; rs7040758

# Macromolecular_Interacting_Partner_5_General_References:
1874447; 3170595; 2785919; 1998498; 2176490; 2684271; 2001356; 7922028; 8736558; 8805557; 9369469

# Macromolecular_Interacting_Partner_5_References:
11162391; 11170467; 12536251; 12824478

# Macromolecular_Interacting_Partner_6_ID:
8066

# Macromolecular_Interacting_Partner_6_Name:
Pulmonary surfactant-associated protein D precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
SP-D; PSP-D; Lung surfactant protein D

# Macromolecular_Interacting_Partner_6_Gene_Name:
SFTPD

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Pulmonary surfactantassociated protein D precursor
MLLFLLSALVLLTQPLGYLEAEMKTYSHRTMPSACTLVMCSSVESGLPGRDGRDGREGPR
GEKGDPGLPGAAGQAGMPGQAGPVGPKGDNGSVGEPGPKGDTGPSGPPGPPGVPGPAGRE
GPLGKQGNIGPQGKPGPKGEAGPKGEVGAPGMQGSAGARGLAGPKGERGVPGERGVPGNA
GAAGSAGAMGPQGSPGARGPPGLKGDKGIPGDKGAKGESGLPDVASLRQQVEALQGQVQH
LQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPFTEAQLLCTQAGGQLASPRSAAENAAL
QQLVVAKNEAAFLSMTDSKTEGKFTYPTGESLVYSNWAPGEPNDDGGSEDCVEIFTNGKW
NDRACGEKRLVVCEF

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
375

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
37699

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
6.54

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_6_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_6_Specific_Function:
Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF01391:Collagen;
PF00059:Lectin_C;
PF09006:Surfac_D-trimer

# Macromolecular_Interacting_Partner_6_Signals:
1-20

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
34767

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
SFTPD_HUMAN (P35247)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SFTPD

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SFTPD

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:10803

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Secreted protein; extracellular space

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1128 bp
ATGCTGCTCTTCCTCCTCTCTGCACTGGTCCTACTCACACAGCCCCTGGGCTACCTGGAA
GCAGAAATGAAGACCTACTCCCACAGAACAACGCCCAGTGCTTGCACCCTGGTCATGTGT
AGCTCAGTGGAGAGTGGCCTGCCTGGTCGCGATGGACGGGATGGGAGAGAGGGCCCTCGG
GGCGAGAAGGGGGACCCAGGTTTGCCAGGAGCTGCAGGGCAAGCAGGGATGCCTGGACAA
GCTGGCCCAGTTGGGCCCAAAGGGGACAATGGCTCTGTTGGAGAACCTGGACCAAAGGGA
GACACTGGGCCAAGTGGACCTCCAGGACCTCCCGGTGTGCCTGGTCCAGCTGGAAGAGAA
GGTCCCCTGGGGAAGCAGGGGAACATAGGACCTCAGGGCAAGCCAGGCCCAAAAGGAGAA
GCTGGGCCCAAAGGAGAAGTAGGTGCCCCAGGCATGCAGGGCTCGGCAGGGGCAAGAGGC
CTCGCAGGCCCTAAGGGAGAGCGAGGTGTCCCTGGTGAGCGTGGAGTCCCTGGAAACGCA
GGGGCAGCAGGGTCTGCTGGAGCCATGGGTCCCCAGGGAAGTCCAGGTGCCAGGGGACCC
CCGGGATTGAAGGGGGACAAAGGCATTCCTGGAGACAAAGGAGCAAAGGGAGAAAGTGGG
CTTCCAGATGTTGCTTCTCTGAGGCAGCAGGTTGAGGCCTTACAGGGACAAGTACAGCAC
CTCCAGGCTGCTTTCTCTCAGTATAAGAAAGTTGAGCTCTTCCCAAATGGCCAAAGTGTC
GGGGAGAAGATTTTCAAGACAGCAGGCTTTGTAAAACCATTTACGGAGGCACAGCTGCTG
TGCACACAGGCTGGTGGACAGTTGGCCTCTCCACGCTCTGCCGCTGAGAATGCCGCCTTG
CAACAGCTGGTCGTAGCTAAGAACGAGGCTGCTTTCCTGAGCATGACTGATTCCAAGACA
GAGGGCAAGTTCACCTACCCCACAGGAGAGTCCCTGGTCTATTCCAACTGGGCCCCAGGG
GAGCCCAACGATGATGGCGGGTCAGAGGACTGTGTGGAGATCTTCACCAATGGCAAGTGG
AATGACAGGGCTTGTGGAGAAAAGCGTCTTGTGGTCTGCGAGTTCTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
X65018

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_6_Locus:
10q22.2-q23.1

# Macromolecular_Interacting_Partner_6_SNPs:
rs721917; rs2243639; rs3088308; rs4469829; rs1051246; rs6413520; rs17885228; rs6413521; rs726014; rs723193; rs726288; rs7074156; rs726287; rs723192; rs2255326; rs958865; rs2819096; rs723191; rs726289; rs17886333; rs911887; rs2181205; rs911886; rs2181204; rs2255601; rs1998374; rs2245121; rs2758545; rs17884887; rs2819098; rs17886630; rs6413518; rs1998375; rs10887199; rs6413519; rs2819097; rs3793925; rs7078012; rs12241521; rs17882021; rs17880779; rs17878707; rs17880072; rs17880086; rs17881639; rs17882375; rs12784549; rs17879583; rs17878456; rs6413523; rs17878441; rs17884499; rs17886726; rs17879858; rs17878650; rs17886286; rs12776624; rs17883490; rs12768733; rs17879726; rs17881730; rs6413522; rs2819100; rs2819101; rs6583888; rs10887215; rs2819099; rs7070197; rs2758547; rs1923536; rs17878664; rs12770776; rs17886233; rs11200738; rs17879607; rs12219080; rs11200737; rs17885031; rs17878916; rs17879667; rs17886602; rs17879444; rs17879238; rs17880868; rs17881828; rs10583219; rs1923534; rs17886714; rs2839718; rs17878336; rs17851984; rs17851983; rs1051240; rs2077117; rs17884760; rs3135520; rs17878740; rs34151269; rs3135516; rs17884943; rs17878788; rs17879471; rs17882169; rs3135512; rs34313048; rs17879434; rs3135510; rs3135515; rs17879081; rs17882040; rs3135519; rs17879187; rs17884985; rs3135511; rs41298237; rs17879274; rs3135514; rs34273420; rs17878558; rs17884441; rs35524015; rs17879262; rs3842640; rs35360945; rs17886982; rs3135513; rs17882051; rs34026028; rs17882492; rs17878493; rs2025199; rs1923535; rs17879336; rs10654647; rs11395828; rs35709137; rs35166130; rs11200736; rs17883537; rs5786427; rs34204007; rs34526451; rs35897636; rs11444784; rs10615356; rs17879359; rs35472737; rs1010775; rs1073479; rs10788319; rs10887218; rs10887226; rs10887234; rs10887235; rs11200714; rs11200729; rs11200859; rs11597219; rs11815922; rs12253608; rs12262739; rs12414616; rs12414891; rs12415523; rs1570328; rs1570329; rs17107449; rs17886393; rs1885549; rs1885550; rs1885551; rs1885552; rs1885553; rs1923537; rs1923538; rs1923539; rs1923540; rs1923541; rs2146191; rs2146192; rs2245545; rs2246111; rs2256167; rs2256185; rs2758550; rs2758551; rs2758554; rs2758555; rs2758556; rs35242206; rs4336977; rs4576757; rs7072378; rs7100426; rs7905105

# Macromolecular_Interacting_Partner_6_General_References:
1339284; 8428971; 1898081; 10368295

# Macromolecular_Interacting_Partner_6_References:
15016617; 15591410

# Macromolecular_Interacting_Partner_7_ID:
7982

# Macromolecular_Interacting_Partner_7_Name:
ATP-binding cassette sub-family G member 1

# Macromolecular_Interacting_Partner_7_Synonyms:
White protein homolog; ATP-binding cassette transporter 8

# Macromolecular_Interacting_Partner_7_Gene_Name:
ABCG1

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>ATPbinding cassette subfamily G member 1
MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNL
TEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPS
GAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMV
SAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFF
DEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGK
VCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGD
AEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDS
VLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLE
MGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAAL
GTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYIS
YVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFI
SLRLIAYFVLRYKIRAER

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
678

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
75593

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
7.87

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  transporter activity
Function:  permease activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_7_Specific_Function:
Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF01061:ABC2_membrane;
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
427-445
457-477
507-525
534-555
568-586
650-669

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
1160186

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
ABCG1_HUMAN (P45844)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
ABCG1

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
ABCG1

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:73

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein. Golgi apparatus; Golgi apparatus membrane; multi-pass membrane protein. Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>2025 bp
ATGGCCGCTTTCTCGGTCGGCACCGCCATGAATGCCAGCAGTTACTCTGCAGAGATGACG
GAGCCCAAGTCGGTGTGTGTCTCGGTGGATGAGGTGGTGTCCAGCAACATGGAGGCCACT
GAGACGGACCTGCTGAATGGACATCTGAAAAAAGTAGATAATAACCTCACGGAAGCCCAG
CGCTTCTCCTCCTTGCCTCGGAGGGCAGCTGTGAACATTGAATTCAGGGACCTTTCCTAT
TCGGTTCCTGAAGGACCCTGGTGGAGGAAGAAAGGATACAAGACCCTCCTGAAAGGAATT
TCCGGGAAGTTCAATAGTGGTGAGTTGGTGGCCATTATGGGTCCTTCCGGGGCCGGGAAG
TCCACGCTGATGAACATCCTGGCTGGATACAGGGAGACGGGCATGAAGGGGGCCGTCCTC
ATCAACGGCCTGCCCCGGGACCTGCGCTGCTTCCGGAAGGTGTCCTGCTACATCATGCAG
GATGACATGCTGCTGCCGCATCTCACTGTGCAGGAGGCCATGATGGTGTCGGCACATCTG
AAGCTTCAGGAGAAGGATGAAGGCAGAAGGGAAATGGTCAAGGAGATACTGACAGCGCTG
GGCTTGCTGTCTTGCGCCAACACGCGGACCGGGAGCCTGTCAGGTGGTCAGCGCAAGCGC
CTGGCCATCGCGCTGGAGCTGGTGAACAACCCTCCAGTCATGTTCTTCGATGAGCCCACC
AGCGGCCTGGACAGCGCCTCCTGCTTCCAGGTGGTCTCGCTGATGAAAGGGCTCGCTCAA
GGGGGTCGCTCCATCATTTGCACCATCCACCAGCCCAGCGCCAAACTCTTCGAGCTGTTC
GACCAGCTTTACGTCCTGAGTCAAGGACAATGTGTGTACCGGGGAAAAGTCTGCAATCTT
GTGCCATATTTGAGGGATTTGGGTCTGAACTGCCCAACCTACCACAACCCAGCAGATTTT
GTCATGGAGGTTGCATCCGGCGAGTACGGTGATCAGAACAGTCGGCTGGTGAGAGCGGTT
CGGGAGGGCATGTGTGACTCAGACCACAAGAGAGACCTCGGGGGTGATGCCGAGGTGAAC
CCTTTTCTTTGGCACCGCCCCTCTGAAGAGGTAAAGCAGACAAAACGATTAAAGGGGTTG
AGAAAGGACTCCTCGTCCATGGAAGGCTGCCACAGCTTCTCTGCCAGCTGCCTCACGCAG
TTCTGCATCCTCTTCAAGAGGACCTTCCTCAGCATCATGAGGGACTCGGTCCTGACACAC
CTGCGCATCACCTCGCACATTGGGATCGGCCTCCTCATTGGCCTGCTGTACTTGGGGATC
GGGAACGAAACCAAGAAGGTCTTGAGCAACTCCGGCTTCCTCTTCTTCTCCATGCTGTTC
CTCATGTTCGCGGCCCTCATGCCTACTGTTCTGACATTTCCCCTGGAGATGGGAGTCTTT
CTTCGGGAACACCTGAACTACTGGTACAGCCTGAAGGCCTACTACCTGGCCAAGACCATG
GCAGACGTGCCCTTTCAGATCATGTTCCCAGTGGCCTACTGCAGCATCGTGTACTGGATG
ACGTCGCAGCCGTCCGACGCCGTGCGCTTTGTGCTGTTTGCCGCGCTGGGCACCATGACC
TCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGAGCCGCCTCCACGTCCCTGCAGGTG
GCCACTTTCGTGGGCCCAGTGACAGCCATCCCGGTGCTCCTGTTCTCGGGGTTCTTCGTC
AGCTTCGACACCATCCCCACGTACCTACAGTGGATGTCCTACATCTCCTATGTCAGGTAT
GGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTAGACCGGGAAGATCTGCACTGTGAC
ATCGACGAGACGTGCCACTTCCAGAAGTCGGAGGCCATCCTGCGGGAGCTGGACGTGGAA
AATGCCAAGCTGTACCTGGACTTCATCGTACTCGGGATTTTCTTCATCTCCCTCCGCCTC
ATTGCCTATTTGGTCCTCAGGTACAAAATCCGGGCAGAGAGGTAA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
X91249

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Locus:
Not Available

# Macromolecular_Interacting_Partner_7_SNPs:
rs915843; rs915842; rs915841; rs4148102; rs4148084; rs4148105; rs8129752; rs8134682; rs692383; rs225412; rs8127716; rs4148086; rs4148106; rs1840593; rs4148085; rs4148107; rs7283103; rs4148101; rs10084554; rs9977571; rs1817200; rs12626951; rs4148087; rs9982034; rs2032259; rs1378575; rs2032260; rs2168344; rs564010; rs1378576; rs8130198; rs225411; rs4148100; rs1044317; rs915845; rs9975740; rs12482369; rs2381040; rs4148090; rs1378574; rs8131563; rs2234715; rs9981390; rs4148103; rs2890566; rs4148083; rs1117640; rs2381038; rs221949; rs9982029; rs7278922; rs2381039; rs4148095; rs9976024; rs2234714; rs4148104; rs10084555; rs12626538; rs11701721; rs4148088; rs12627318; rs1598482; rs1824011; rs7277707; rs2839478; rs425215; rs225398; rs2234719; rs532345; rs225378; rs450808; rs225394; rs225371; rs2839480; rs225401; rs225441; rs11910928; rs225370; rs225447; rs3788002; rs2839481; rs691687; rs3787970; rs3788010; rs4148123; rs225409; rs2234721; rs225443; rs881394; rs2234718; rs9975333; rs8132809; rs914189; rs3787978; rs7280003; rs2839482; rs225448; rs183436; rs225387; rs4148125; rs178744; rs225445; rs225372; rs225393; rs881395; rs225446; rs225410; rs6586298; rs4148137; rs225440; rs3827228; rs4148117; rs2276233; rs225407; rs915847; rs8134674; rs225386; rs8129569; rs225374; rs4920080; rs7279750; rs915846; rs7281345; rs482303; rs7281093; rs225382; rs3787965; rs225406; rs225388; rs6586300; rs3787968; rs7275482; rs3827225; rs17767083; rs225395; rs225444; rs4148139; rs11909889; rs225400; rs225391; rs225381; rs225380; rs8128565; rs170445; rs2276235; rs182694; rs225376; rs2298690; rs3788007; rs225385; rs225399; rs225403; rs6586301; rs492338; rs413650; rs225405; rs6586299; rs7277991; rs4148124; rs3787966; rs2298689; rs225379; rs3787986; rs17114631; rs225408; rs225383; rs4148133; rs225396; rs225402; rs413656; rs225449; rs3787972; rs178743; rs9982242; rs3787997; rs12627548; rs17114583; rs11702801; rs7283699; rs225413; rs9976804; rs3787985; rs8134787; rs74757; rs17114590; rs3788001; rs225390; rs8134486; rs3788009; rs4148118; rs9980952; rs8127340; rs3787971; rs4148122; rs4148111; rs12329683; rs3788006; rs3787994; rs184433; rs10788646; rs4148114; rs9974658; rs4148135; rs225377; rs13052462; rs1311800; rs17114581; rs9978842; rs474142; rs3787967; rs3787995; rs13050646; rs11700907; rs225373; rs461129; rs441626; rs4920077; rs3827227; rs4148134; rs225392; rs3787979; rs9984462; rs9978671; rs9982196; rs170436; rs9974417; rs4920081; rs12483381; rs17114591; rs4148120; rs17114604; rs8126601; rs8130374; rs3788005; rs9653812; rs225384; rs225375; rs9975218; rs427716; rs3788000; rs551928; rs1893590; rs1378577; rs9325632; rs4148082; rs12626718; rs7281320; rs35141461; rs7281684; rs8131089; rs28519543; rs8130893; rs4920072; rs28494082; rs35282280; rs13047540; rs1824010; rs4148093; rs4148098; rs9975490; rs34786983; rs4919978; rs8126971; rs28760964; rs221948; rs692369; rs6147522; rs13046865; rs11367330; rs28435557; rs34068794; rs13051040; rs35328038; rs1893591; rs4148091; rs8134346; rs35840150; rs34118939; rs4148092; rs13051078; rs4148099; rs7281377; rs34140987; rs4148089; rs8134684; rs4148143; rs35291846; rs9975154; rs35925967; rs11372946; rs8129302; rs436368; rs13048493; rs4327312; rs34880593; rs11271747; rs8131925; rs13051166; rs34116920; rs3746913; rs34146976; rs4148094; rs4148144; rs35946579; rs34384834; rs28476477; rs35447696; rs12106329; rs7275664; rs11700802; rs13047412; rs8130516; rs13052527; rs9979687; rs3787981; rs3788008; rs4148109; rs1312077; rs8132611; rs4148110; rs7281676; rs4920079; rs498754; rs34794634; rs4919982; rs4148126; rs34349454; rs35478444; rs34234921; rs1797424; rs35873421; rs9982016; rs35280343; rs3827224; rs36033318; rs7280035; rs8130228; rs7278062; rs9975632; rs8130657; rs3787964; rs4148113; rs35436100; rs35477367; rs36054436; rs3787996; rs34768841; rs8127035; rs34578735; rs2234720; rs11411618; rs35863961; rs35519182; rs4148130; rs4148136; rs9977145; rs3787976; rs1036803; rs8133920; rs11330762; rs35325051; rs170444; rs36031456; rs4148115; rs7278222; rs3787982; rs8131852; rs225442; rs28463023; rs4148127; rs4919981; rs9979602; rs11701894; rs9984192; rs4919980; rs10541277; rs9982284; rs13049646; rs9979677; rs28731398; rs9974993; rs34585398; rs8128750; rs10665577; rs28510925; rs3787999; rs35948230; rs34520302; rs10675134; rs35522463; rs9979482; rs9983344; rs170440; rs34933653; rs35823612; rs35276014; rs1126222; rs35000523; rs4148119; rs170439; rs170441; rs8134199; rs10590039; rs7283123; rs4148128; rs35875847; rs170437; rs9978294; rs2000763; rs34030542; rs11911691; rs11402831; rs28701778; rs551970; rs3842456; rs12627529; rs4148132; rs1036804; rs3788003; rs11330761; rs4148112; rs35899486; rs8132392; rs1311799; rs35004862; rs1312076; rs4148147; rs34756314; rs34994549; rs35921043; rs28675969; rs35168988; rs4148138; rs2234717; rs11701502; rs2849720; rs1311798; rs35533965; rs9979594; rs3787987; rs34256469; rs4920075; rs3787980; rs3787984; rs35942249; rs7283570; rs9979676; rs7280114; rs4148129; rs10523936; rs33947634; rs225397; rs36078877; rs170438; rs8134263; rs28377560; rs10656512; rs1311801; rs35215336; rs36013117; rs4148131; rs8132393; rs9978287; rs35972398; rs35066189; rs8130349; rs34761716; rs172826; rs9979589; rs11277234; rs4148141; rs2276234; rs8133786; rs10592727; rs9979980; rs10550045; rs731663; rs692547; rs7279161; rs3787977; rs35140177; rs4148116; rs35777749; rs225404; rs4148121; rs33951854; rs28686779; rs4148108; rs36039103; rs691545; rs9976437; rs35927717; rs11701788; rs11908805; rs11910365; rs11910395; rs11911417; rs13049710; rs13053126; rs1541290; rs15661; rs17114504; rs1893589; rs221950; rs225434; rs225435; rs2381037; rs2839477; rs2839483; rs2839484; rs2839485; rs35803624; rs3746915; rs3746916; rs3746917; rs449087; rs4547619; rs6586304; rs6586305; rs6586306; rs6586307; rs7276176; rs7277545; rs7279654; rs7281065; rs7281551; rs7283700; rs748318; rs748319; rs748320; rs750817; rs750818; rs8126796; rs8128237; rs8128478; rs8129519; rs8129532; rs8131660; rs915844; rs9984673

# Macromolecular_Interacting_Partner_7_General_References:
8659545; 10830953; 10950923; 11279031; 11162488; 11500512; 9034316; 10799558; 10639163; 12032171; 11590207

# Macromolecular_Interacting_Partner_7_References:
10809785; 11027475; 11162101; 12225853

# Macromolecular_Interacting_Partner_8_ID:
8084

# Macromolecular_Interacting_Partner_8_Name:
ATP-sensitive inward rectifier potassium channel 1

# Macromolecular_Interacting_Partner_8_Synonyms:
Potassium channel, inwardly rectifying subfamily J member 1; ATP-regulated potassium channel ROM-K; Kir1.1

# Macromolecular_Interacting_Partner_8_Gene_Name:
KCNJ1

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>ATPsensitive inward rectifier potassium channel 1
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
391

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
44795

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
9.04

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  transporter activity
Function:  ion transporter activity
Function:  ion channel activity
Function:  voltage-gated ion channel activity
Function:  voltage-gated potassium channel activity
Function:  inward rectifier potassium channel activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  cation transport
Process:  monovalent inorganic cation transport
Process:  potassium ion transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF01007:IRK

# Macromolecular_Interacting_Partner_8_Signals:
None

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
78-102
156-177

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
529313

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
IRK1_HUMAN (P48048)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
KCNJ1

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
KCNJ1

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:6255

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1176 bp
ATGAATGCTTCCAGTCGGAATGTGTTTGACACGTTGATCAGGGTGTTGACAGAAAGTATG
TTCAAACATCTTCGGAAATGGGTCGTCACTCGCTTTTTTGGGCATTCTCGGCAAAGAGCA
AGGCTAGTCTCCAAAGATGGAAGGTGCAACATAGAATTTGGCAATGTGGAGGCACAGTCA
AGGTTTATATTCTTTGTGGACATCTGGACAACGGTACTTGACCTCAAGTGGAGATACAAA
ATGACCATTTTCATCACAGCCTTCTTGGGGAGTTGGTTTTTCTTTGGTCTCCTGTGGTAT
GCAGTAGCGTACATTCACAAAGACCTCCCGGAATTCCATCCTTCTGCCAATCACACTCCC
TGTGTGGAGAATATTAATGGCTTGACCTCAGCTTTTCTGTTTTCTCTGGAGACTCAAGTG
ACCATTGGATATGGATTCAGGTGTGTGACAGAACAGTGTGCCACTGCCATTTTTCTGCTT
ATCTTTCAGTCTATACTTGGAGTTATAATCAATTCTTTCATGTGTGGGGCCATCTTAGCC
AAGATCTCCAGGCCCAAAAAACGTGCCAAGACCATTACGTTCAGCAAGAACGCAGTGATC
AGCAAACGGGGAGGGAAGCTTTGCCTCCTAATCCGAGTGGCTAATCTCAGGAAGAGCCTT
CTTATTGGCAGTCACATTTATGGAAAGCTTCTGAAGACCACAGTCACTCCTGAAGGAGAG
ACCATTATTTTGGACCAGATCAATATCAACTTTGTAGTTGACGCTGGGAATGAAAATTTA
TTCTTCATCTCCCCATTGACAATTTACCATGTCATTGATCACAACAGCCCTTTCTTCCAC
ATGGCAGCGGAGACCCTTCTCCAGCAGGACTTTGAATTAGTGGTGTTTTTAGATGGCACA
GTGGAGTCCACCAGTGCTACCTGCCAAGTCCGGACATCCTATGTCCCAGAGGAGGTGCTT
TGGGGCTACCGTTTTGCTCCCATAGTATCCAAGACAAAGGAAGGGAAATACCGAGTGGAT
TTCCATAACTTTAGCAAGACAGTGGAAGTGGAGACCCCTCACTGTGCCATGTGCCTTTAT
AATGAGAAAGATGTTAGAGCCAGGATGAAGAGAGGCTATGACAACCCCAACTTCATCTTG
TCAGAAGTCAATGAAACAGATGACACCAAAATGTAA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
U12541

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_8_Locus:
11q24

# Macromolecular_Interacting_Partner_8_SNPs:
rs34191956; rs2855800; rs1893140; rs2855794; rs2855798; rs2186832; rs675482; rs1148059; rs2855797; rs581472; rs673614; rs2847377; rs3016774; rs668393; rs583352; rs2509585; rs2238009; rs1231254; rs610155; rs6590353; rs11601659; rs675759; rs1237737; rs675388; rs1148058; rs1148061; rs2855796; rs17137982; rs11600347; rs7925428; rs673992; rs2855790; rs2846680; rs7120491; rs10893926; rs7128935; rs743619; rs2847381; rs2040361; rs628461; rs11221483; rs694165; rs637992; rs10893924; rs3181542; rs17137967; rs658903; rs2301152; rs1148060; rs619399; rs7933427; rs12419532; rs10893925; rs2846679; rs17137971; rs7925884; rs12795437; rs3867248; rs3758766; rs2847379; rs2846682; rs11821866; rs2855799; rs646617; rs41302407; rs35938603; rs1148067; rs1794053; rs2855792; rs12793045; rs1237736; rs10584447; rs2846684; rs1231249; rs3016773; rs762683; rs1231251; rs662765; rs1148073; rs10545865; rs35906709; rs34359095; rs1794061; rs7114745; rs2323270; rs2256921; rs1148070; rs12804241; rs2847382; rs2855791; rs35165862; rs34426167; rs35939654; rs916007; rs2847380; rs35421007; rs1234677; rs11221480; rs1148071; rs2323163; rs36064277; rs2323271; rs35594648; rs7128736; rs1235051; rs1785757; rs9736602; rs12805828; rs1231256; rs1148069; rs2847378; rs7117664; rs11221481; rs35478303; rs2323269; rs1148057; rs1787974; rs916008; rs592796; rs2040360; rs1148072; rs35847988; rs1794064; rs1148068; rs35873314; rs2846681; rs34666450; rs34029260; rs1794057; rs1787975; rs1787973; rs1231250; rs2855801; rs34872010; rs12806867; rs5795647; rs7117169; rs11601913; rs1794055; rs2846683; rs11608058; rs12575121; rs12807049; rs11221478; rs2855793; rs12808372; rs12576196; rs11398916; rs12574015; rs1034373; rs10750404; rs10790974; rs10893922; rs11221484; rs11221485; rs11221486; rs11221487; rs11221488; rs11603786; rs11820906; rs12278139; rs12279915; rs12797340; rs1794058; rs1893138; rs1893139; rs3016772; rs4529890; rs4937378; rs4937379; rs587170; rs588472; rs588957; rs588986; rs603386; rs651925; rs6590354; rs664451; rs680276; rs7116606; rs7925269; rs7943324; rs881333; rs948215

# Macromolecular_Interacting_Partner_8_General_References:
7929082; 8190102; 7635463; 9002665

# Macromolecular_Interacting_Partner_8_References:
11880626; 11956191; 12381730

# Macromolecular_Interacting_Partner_9_ID:
7883

# Macromolecular_Interacting_Partner_9_Name:
Ubiquitin

# Macromolecular_Interacting_Partner_9_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_9_Gene_Name:
RPS27A

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Ubiquitin
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN
IQKESTLHLVLRLRGG

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
76

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
8565

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
7.54

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00240:ubiquitin

# Macromolecular_Interacting_Partner_9_Signals:
None

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
340068

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
UBIQ_HUMAN (P62988)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
RPS27A

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
RPS27A

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:10417

# Macromolecular_Interacting_Partner_9_PDB_ID:
1V81

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Cytoplasm. Nucleus

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>2058 bp
ATGCAGATCTTCGTGAAGACTCTGACTGGTAAGACCATCACCCTCGAGGTGGAGCCCAGT
GACACCATCGAGAATGTCAAGGCAAAGATCCAAGATAAGGAAGGCATTCCTCCTGATCAG
CAGAGGTTGATCTTTGCCGGAAAACAGCTGGAAGATGGTCGTACCCTGTCTGACTACAAC
ATCCAGAAAGAGTCCACCTTGCACCTGGTACTCCGTCTCAGAGGTGGGATGCAAATCTTC
GTGAAGACACTCACTGGCAAGACCATCACCCTTGAGGTCGAGCCCAGTGACACAATCGAG
AACGTCAAGGCAAAGATCCAAGACAAGGAAGGCATTCCTCCTGACCAGCAGAGGTTGATC
TTTGCCGGAAAGCAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATCCAGAAAGAG
TCTACCCTGCACCTGGTGCTCCGTCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTG
ACTGGTAAGACCATCACCCTCGAAGTGGAGCCGAGTGACACCATTGAGAATGTCAAGGCA
AAGATCCAAGACAAGGAAGGCATCCCTCCTGACCAGCAGAGGTTGATCTTTGCCGGAAAA
CAGCTGGAAGATGGTCGTACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCTTGCAC
CTGGTGCTCCGTCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTGACTGGTAAGACC
ATCACTCTCGAGGTGGAGCCGAGTGACACCATTGAGAATGTCAAGGCAAAGATCCAAGAC
AAGGAAGGCATCCCTCCTGATCAGCAGAGGTTGATCTTTGCTGGGAAACAGCTGGAAGAT
GGACGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTGGTGCTCCGT
CTTAGAGGTGGGATGCAGATCTTCGTGAAGACCCTGACTGGTAAGACCATCACTCTCGAA
GTGGAGCCGAGTGACACCATTGAGAATGTCAAGGCAAAGATCCAAGACAAGGAAGGCATC
CCTCCTGACCAGCAGAGGTTGATCTTTGCTGGGAAACAGCTGGAAGATGGACGCACCCTG
TCTGACTACAACATCCAGAAAGAGTCCACCCTGCACCTGGTTCTCCGTCTTAGAGGTGGG
ATGCAGATCTTCGTGAAGACCCTGACTGGTAAGACCATCACTCTCGAAGTGGAGCCGAGT
GACACCATTGAGAATGTCAAGGCAAAGATCCAAGACAAGGAAGGCATCCCTCCTGACCAG
CAGAGGTTGATCTTTGCTGGGAAACAGCTGGAAGATGGACGCACCCTGTCTGACTACAAC
ATCCAGAAAGAGTCCACCCTGCACCTGGTGCTCCGTCTCAGAGGTGGGATGCAGATCTTC
GTGAAGACCCTGACTGGTAAGACCATCACCCTCGAGGTTGAGCCCAGTGACACCATCGAG
AATGTCAAGGCAAAGATCCAAGATAAGGAAGGCATCCCTCCTGATCAGCAGAGGTTGATC
TTTGCTGGAAAACAGCTGGAAGATGGGCGCACCCTGTCTGACTACAACATTCAGAAAGAG
TCCACCCTGCACCTGGTGCTCCGTCTCAGAGGTGGGATGCAAATCTTCGTGAAGACACTC
ACTGGCAAGACCATCACCCTTGAGGTGGAGCCCAGTGACACCATCGAGAACGTCAAGGCA
AAGATCCAGGACAAGGAAGGCATTCCTCCTGACCAGCAGAGGTTGATCTTTGCCGGAAAG
CAGCTGGAAGATGGGCGGACCCTGTCTGACTACAACATCCAGAAAGAGTCTACCCTGCAC
CTGGTGCTCCGTCTCAGAGGTGGGATGCAGATCTTCGTGAAGACCCTGACTGGTAAGACC
ATTACCCTCGAGGTGGAGCCCAGTGACACCATCGAGAATGTCAAGGCAAAGATCCAAGAT
AAGGAAGGCATCCCTCCTGATCAGCAGAGGTTGATCTTTGCTGGGAAACAGCTGGAAGAT
GGACGCACCCTGTCTGACTACAACATCCAGAAAGAGTCCACTCTGCACTTGGTCCTGCGC
TTGAGGGGGGGTGTCTAA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
M26880

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_9_Locus:
2p16

# Macromolecular_Interacting_Partner_9_SNPs:
Not Available

# Macromolecular_Interacting_Partner_9_General_References:
2988935; 2820408; 3029682; 1850507; 1657614; 1370760; 8917096; 9504932; 2581967; 124018; 3041007; 8166633; 8107144

# Macromolecular_Interacting_Partner_9_References:
12028574; 12588869; 15801793; 16123137

End of HMDB00163

Beginning of HMDB00164
# Accession_No:
HMDB00164

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-20 10:42:41

# biospider_lastupdate:
2007-07-25 10:24:49

# Common_Name:
Methylamine

# Description:
Methylamine is the chemical compound with a formula of CH3NH2. It is a derivative of ammonia, wherein one H atom is replaced by a methyl group. It is usually sold as solutions in methanol (2M), ethanol (8M), THF (2M), and water (40%), or as the anhydrous gas in pressurized metal containers. It has a strong odour similar to rotten fish. Methylamine is used both as a solvent and as a building block for the synthesis of other organic compounds. It is on the DEA watchlist for chemical precursors because of clandestine use in manufacture of the drug MDMA (ecstasy) and methamphetamine.; The hydrochloride salt of methylamine, methylammonium chloride, CH3NH3Cl, is a colourless powder that can be converted to the amine.; Methylamine is a good nucleophile as it is highly basic and unhindered. Its use in organic chemistry is pervasive. For example, it is a precursor to CH3NCS.

# Synonyms:
Monomethylammonium chloride; Methanamine; Methylamine solutions; N-methylammonium chloride; Methylamine aqueous solution; Monomethylamine; Methylamine solution; Anhydrous methylamine; Methylamine hydrochloride; NME; Carbinamine; Methylaminen; NMA; Methyl of gamma-n-methylasparagine; Mathylamine hydrochloride; Metilamine; Metyloamina; Methyl group; Aminomethane; MMA; Mercurialin; Methylamine anhydrous; N-methylamine; Imizin; Methylamine

# Chemical_IUPAC_Name:
methanamine

# Chemical_Formula:
CH5N

# Chemical_Structure:
tbl_chemical:::HMDB00164_ZOOM.png:::119283229030768008

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00164_THUMB.png:::119283228894330664

# Taxonomy_Kingdom:
Inorganic

# Taxonomy_Class:
Aliphatic Amines; Aromatic Amines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine)

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
31.04220

# Molecular_Weight_Avg:
31.05710

# Smiles_String_isomeric:
CN

# Smiles_String_canonical:
CN

# KEGG_Compound_ID:
C00218

# BioCyc_ID:
CPD-4521

# PubChem_CID:
6329

# PubChem_SID:
826516; 8153994; 3518; 24874428; 8005431; 11532186; 10534693; 3133830; 8011185; 8009427; 24874430; 838152; 11532204; 821170; 11532181; 8017451; 7889431; 14709304; 24864638; 14716080; 819998; 7991773; 584290; 8026122; 552538; 5007254; 837738; 8004993; 8007306; 24878015; 149270; 24866706; 10323857; 11532173; 24864637; 8006865; 15296834; 24277479; 24874427; 8029475; 589718; 819991; 8143629; 11532199; 24857793; 8013979

# OMIM_ID:
136131

# Metagene_ID:
Not Available

# BiGG_ID:
1800349

# Wikipedia_ID:
Methylamine

# METLIN_ID:
3767

# Ref_ID:
14500886; 12787933; 10817881; 2703191; 14697905; 12097436; 8405530; 12807388; 2361964; 947625; 12738750; 7762816; 9060087

# ChEBI_ID:
16830

# CAS_Registry_Number:
74-89-5

# InChI:
InChI=1/CH5N/c1-2/h2H2,1H3

# Synthesis_Reference:
 Journal of the Chemical Society, Transactions  (1920),  117  236-47.

# Melting_Point:
-93.4 oC

# Melting_Point_predicted:
15.2 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1080.0 mg/mL [SCHWEIZER,AE et al. (1978)]

# H2O_Solubility_Predicted:
367.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
1

# State:
Gas

# LogP:
-0.57 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-1.05 [Predicted by ALOGPS]; -0.6 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Methylamine.pdf:::1132562209582880563

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Methylamine.mol:::1132723811375451737

# SDF_File_[Text]:
tbl_chemical:::HMDB00164.sdf:::119283228626573862

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00164.pdb:::119283228757986247

# PDB_ID:
1U7C

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041020_P00_04_HW_1DP_presat.png:::114617931989350671

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041020_P00_04_HW_1DP_presat.zip:::114617931989841119

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041020_P00_04_HW_1DP_Assigned.png:::114624595464814562

# H_NMR_Spectra_Sykes:


# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041020_P00_04_HW_1DP_Presat.zip:::115514122694983841

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
tbl_cnmr:::041020_P00_04_HW_1DC_131.jpg:::11417472285059756

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041020_P00_04_HW_1DC_131.zip:::11417472285736265

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041020_P00_04_HW_1DC_131_Assigned.jpg:::114332843896676119

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041020_P00_04_HW_2DHSQC_55.jpg:::114781398446781709

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041020_P00_04_HW_2DHSQC_55.zip:::114781398447820178

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041020_P00_04_HW_2DHSQC_55_Assigned.jpg:::114781398458943543

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Methylamine.gif:::1132732116515923006

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00164_peaks.txt:::1156309589645553941

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Methylamine_C.gif:::1132737707249497509

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00164_peaks.txt:::1156310779246688328

# Mass_Spectrum:
Low Energy:tbl_ms:::00164L.png:::118047895965360251; Medium Energy:tbl_ms:::00164M.png:::118047895965048455; High Energy:tbl_ms:::00164H.png:::118047895968668055

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Blood; Saliva

# Concentration_[Normal]:
Blood	>10.0	umol/L	Adult:>18_yrs_old	Both	Normal	7762816
Saliva	158 (0.00-316)	umol/L	Adult:>18_yrs_old	Both	Normal	12097436


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Insulin Dependent Diabetes Mellitus

# Pathway_Names:
Not Available

# Pathway_Images:
Not Available

# KEGG_Images:
Not Available

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5630

# Metabolic_Enzyme_1_Name:
Membrane copper amine oxidase

# Metabolic_Enzyme_1_Synonyms:
Semicarbazide-sensitive amine oxidase; SSAO; Vascular adhesion protein 1; VAP-1; HPAO

# Metabolic_Enzyme_1_Gene_Name:
AOC3

# Metabolic_Enzyme_1_Protein_Sequence:
>Membrane copper amine oxidase
MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVW
AEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHP
RGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDF
SDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSA
DSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN

# Metabolic_Enzyme_1_Number_of_Residues:
763

# Metabolic_Enzyme_1_Molecular_Weight:
84623

# Metabolic_Enzyme_1_Theoretical_pI:
6.51

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_1_Specific_Function:
Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity

# Metabolic_Enzyme_1_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_1_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_1_Signals:
1-19

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1399032

# Metabolic_Enzyme_1_SwissProt_ID:
AOC3_HUMAN (Q16853)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
AOC3

# Metabolic_Enzyme_1_Geneatlas_id:
AOC3

# Metabolic_Enzyme_1_hgnc_id:
HGNC:550

# Metabolic_Enzyme_1_PDB_ID:
1PU4

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_1_Gene_Sequence:
>2292 bp
ATGAACCAGAAGACAATCCTCGTGCTCCTCATTCTGGCCGTCATCACCATCTTTGCCTTG
GTTTGTGTCCTGCTGGTGGGCAGGGGTGGAGATGGGGGTGAACCCAGCCAGCTTCCCCAT
TGCCCCTCTGTATCTCCCAGTGCCCAGCCTTGGACACACCCTGGCCAGAGCCAGCTGTTT
GCAGACCTGAGCCGAGAGGAGCTGACGGCTGTGATGCGCTTTCTGACCCAGCGGCTGGGG
CCAGGGCTGGTGGATGCAGCCCAGGCCCGGCCCTCGGACAACTGTGTCTTCTCAGTGGAG
TTGCAGCTGCCTCCCAAGGCTGCAGCCCTGGCTCACTTGGACAGGGGGAGCCCCCCACCT
GCCCGGGAGGCACTGGCCATCGTCTTCTTTGGCAGGCAACCCCAGCCCAACGTGAGTGAG
CTGGTGGTGGGGCCACTGCCTCACCCCTCCTACATGCGGGACGTGACTGTGGAGCGTCAT
GGAGGCCCCCTGCCCTATCACCGACGCCCCGTGCTGTTCCAAGAGTACCTGGACATAGAC
CAGATGATCTTCAACAGAGAGCTGCCCCAGGCTTCTGGGCTTCTCCACCACTGTTGCTTC
TACAAGCACCGGGGACGGAACCTGGTGACAATGACCACGGCTCCCCGTGGTCTGCAATCA
GGGGACCGGGCCACCTGGTTTGGCCTCTACTACAACATCTCGGGCGCTGGGTTCTTCCTG
CACCACGTGGGCTTGGAGCTGCTAGTGAACCACAAGGCCCTTGACCCTGCCCGCTGGACT
ATCCAGAAGGTGTTCTATCAAGGCCGCTACTACGACAGCCTGGCCCAGCTGGAGGCCCAG
TTTGAGGCCGGCCTGGTGAATGTGGTGCTGATCCCAGACAATGGCACAGGTGGGTCCTGG
TCCCTGAAGTCCCCTGTGCCCCCGGGTCCAGCTCCCCCTCTACAGTTCTATCCCCAAGGC
CCCCGCTTCAGTGTCCAGGGAAGTCGAGTGGCCTCCTCACTGTGGACTTTCTCCTTTGGC
CTCGGAGCATTCAGTGGCCCAAGGATCTTTGACGTTCGCTTCCAAGGAGAAAGACTAGTT
TATGAGATAAGCCTCCAAGAGGCCTTGGCCATCTATGGTGGAAATTCCCCAGCAGCAATG
ACGACCCGCTATGTGGATGGAGGCTTTGGCATGGGCAAGTACACCACGCCCCTGACCCGT
GGGGTGGACTGCCCCTACTTGGCCACCTACGTGGACTGGCACTTCCTTTTGGAGTCCCAG
GCCCCCAAGACAATACGTGATGCCTTTTGTGTGTTTGAACAGAACCAGGGCCTCCCCCTG
CGGCGACACCACTCAGATCTCTACTCGCACTACTTTGGGGGTCTTGCGGAAACGGTGCTG
GTCGTCAGATCTATGTCCACCTTGCTCAACTATGACTATGTGTGGGATACGGTCTTCCAC
CCCAGTGGGGCCATAGAAATACGATTCTATGCCACGGGCTACATCAGCTCGGCATTCCTC
TTTGGTGCTACTGGGAAGTACGGGAACCAAGTGTCAGAGCACACCCTGGGCACGGTCCAC
ACCCACAGCGCCCACTTCAAGGTGGATCTGGATGTAGCAGGACTGGAGAACTGGGTCTGG
GCCGAGGATATGGTCTTTGTCCCCATGGCTGTGCCCTGGAGCCCTGAGCACCAGCTGCAG
AGGCTGCAGGTGACCCGGAAGCTGCTGGAGATGGAGGAGCAGGCCGCCTTCCTCGTGGGA
AGCGCCACCCCTCGCTACCTGTACCTGGCCAGCAACCACAGCAACAAGTGGGGTCACCCC
CGGGGCTACCGCATCCAGATGCTCAGCTTTGCTGGAGAGCCGCTGCCCCAAAACAGCTCC
ATGGCGAGAGGCTTCAGCTGGGAGAGGTACCAGCTGGCTGTGACCCAGCGGAAGGAGGAG
GAGCCCAGTAGCAGCAGCGTTTTCAATCAGAATGACCCTTGGGCCCCCACTGTGGATTTC
AGTGACTTCATCAACAATGAGACCATTGCTGGAAAGGATTTGGTGGCCTGGGTGACAGCT
GGTTTTCTGCATATCCCACATGCAGAGGACATTCCTAACACAGTGACTGTGGGGAACGGC
GTGGGCTTCTTCCTCCGACCCTATAACTTCTTTGACGAAGACCCCTCCTTCTACTCTGCC
GACTCCATCTACTTCCGAGGGGACCAGGATGCTGGGGCCTGCGAGGTCAACCCCCTAGCT
TGCCTGCCCCAGGCTGCTGCCTGTGCCCCCGACCTCCCTGCCTTCTCCCACGGGGGCTTC
TCTCACAACTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U39447

# Metabolic_Enzyme_1_Chromosome_Location:
Not Available

# Metabolic_Enzyme_1_Locus:
Not Available

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
8972912; 9653080

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5393

# Metabolic_Enzyme_2_Name:
Amine oxidase [flavin-containing] B

# Metabolic_Enzyme_2_Synonyms:
Monoamine oxidase type B; MAO-B

# Metabolic_Enzyme_2_Gene_Name:
MAOB

# Metabolic_Enzyme_2_Protein_Sequence:
>Amine oxidase flavincontaining 
BMSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGS
YVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFW
RTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHE
VSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYID
QTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIV
YYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEE
RLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVD
RIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITT
TFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV

# Metabolic_Enzyme_2_Number_of_Residues:
520

# Metabolic_Enzyme_2_Molecular_Weight:
58764

# Metabolic_Enzyme_2_Theoretical_pI:
7.55

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine

# Metabolic_Enzyme_2_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_2_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01593:Amino_oxidase

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
490-516

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.4.3.4

# Metabolic_Enzyme_2_GenBank_ID_Protein:
398415

# Metabolic_Enzyme_2_SwissProt_ID:
AOFB_HUMAN (P27338)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
MAOB

# Metabolic_Enzyme_2_Geneatlas_id:
MAOB

# Metabolic_Enzyme_2_hgnc_id:
HGNC:6834

# Metabolic_Enzyme_2_PDB_ID:
2BK3

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type IV membrane protein; cytoplasmic side

# Metabolic_Enzyme_2_Gene_Sequence:
>1560 bp
ATGAGCAACAAATGCGACGTGGTCGTGGTGGGGGGCGGCATCTCAGGTATGGCAGCAGCC
AAACTTCTGCATGACTCTGGACTGAATGTGGTTGTTCTGGAAGCCCGGGACCGTGTGGGA
GGCAGGACTTACACTCTTAGGAACCAAAAGGTTAAATATGTGGACCTTGGAGGATCCTAT
GTTGGACCAACCCAGAATCGTATCTTGAGATTAGCCAAGGAGCTAGGATTGGAGACCTAC
AAAGTGAATGAGGTTGAGCGTCTGATCCACCATGTAAAGGGCAAATCATACCCCTTCAGG
GGGCCATTCCCACCTGTATGGAATCCAATTACCTACTTAGATCATAACAACTTTTGGAGG
ACAATGGATGACATGGGGCGAGAGATTCCGAGTGATGCCCCATGGAAGGCTCCCCTTGCA
GAAGAGTGGGACAACATGACAATGAAGGAGCTACTGGACAAGCTCTGCTGGACTGAATCT
GCAAAGCAGCTTGCCACTCTCTTTGTGAACCTGTGTGTCACTGCAGAGACCCATGAGGTC
TCTGCTCTCTGGTTCCTGTGGTATGTGAAGCAGTGTGGAGGCACAACAAGAATCATCTCG
ACAACAAATGGAGGACAGGAGAGGAAATTTGTGGGCGGATCTGGTCAAGTGAGTGAGCGG
ATAATGGACCTCCTTGGAGACCGAGTGAAGCTGGAGAGGCCTGTGATCTACATTGACCAG
ACAAGAGAAAATGTCCTTGTGGAGACCCTAAACCATGAGATGTATGAGGCTAAATATGTG
ATTAGTGCTATTCCTCCTACTCTGGGCATGAAGATTCACTTCAATCCCCCTCTGCCAATG
ATGAGAAACCAGATGATCACTCGTGTGCCTTTGGGTTCAGTCATCAAGTGTATAGTTTAT
TATAAAGAGCCTTTCTGGAGGAAAAAGGATTACTGTGGAACCATGATTATTGATGGAGAA
GAAGCTCCAGTTGCCTACACGTTGGATGATACCAAACCTGAAGGCAACTATGCTGCCATA
ATGGGATTTATCCTGGCCCACAAAGCCAGAAAACTGGCACGTCTTACCAAAGAGGAAAGG
TTGAAGAAACTTTGTGAACTCTATGCCAAGGTTCTGGGTTCCCTAGAAGCTCTGGAGCCA
GTGCATTATGAAGAAAAGAACTGGTGTGAGGAGCAGTACTCTGGGGGCTGCTACACAACT
TATTTCCCCCCTGGGATCCTGACTCAATATGGAAGGGTTCTACGCCAGCCAGTGGACAGG
ATTTACTTTGCAGGCACCGAGACTGCCACACACTGGAGCGGCTACATGGAGGGGGCTGTA
GAGGCCGGGGAGAGAGCAGCCCGAGAGATCCTGCATGCCATGGGGAAGATTCCAGAGGAT
GAAATCTGGCAGTCAGAACCAGAGTCTGTGGATGTCCCTGCACAGCCCATCACCACCACC
TTTTTGGAGAGACATTTGCCCTCCGTGCCAGGCCTGCTCAGGCTGATTGGATTGACCACC
ATCTTTTCAGCAACGGCTCTTGGCTTCCTGGCCCACAAAAGGGGGCTACTTGTGAGAGTC


# Metabolic_Enzyme_2_GenBank_ID_Gene:
S62734

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_2_Locus:
Xp11.23

# Metabolic_Enzyme_2_SNPs:
rs7879356; rs6324; rs12010260; rs2072745; rs17462; rs3027440; rs7066677; rs3027439; rs1799836; rs3027453; rs2311013; rs3027441; rs5905512; rs3027459; rs2239450; rs2239441; rs7890174; rs5952297; rs3027444; rs5952330; rs7883073; rs5952671; rs6520902; rs2239449; rs6651806; rs3027454; rs7057075; rs12394221; rs2238969; rs12008119; rs7888450; rs12388038; rs2283727; rs12013965; rs17310637; rs12008438; rs5952294; rs5952340; rs12008548; rs12014398; rs1014876; rs3027449; rs2283730; rs2283729; rs5952813; rs6520901; rs5952352; rs2205655; rs10521432; rs6610856; rs12006628; rs3027450; rs6610853; rs2283731; rs3027456; rs2283728; rs9887326; rs5952325; rs3027442; rs7879586; rs12389168; rs3817729; rs12851487; rs5952686; rs3736672; rs2056913; rs1569424; rs7053203; rs2092042; rs7876594; rs12010996; rs3027457; rs9887047; rs3027451; rs17146716; rs7061798; rs3027464; rs6609259; rs3027446; rs736944; rs2239442; rs6609260; rs7067187; rs3027466; rs12558324; rs7888462; rs3027452; rs2092040; rs4824562; rs17146721; rs7884044; rs3027461; rs12389234; rs12007768; rs17244906; rs5952795; rs17146719; rs5905449; rs5952799; rs12394863; rs3027458; rs3027443; rs9698576; rs2092041; rs7892217; rs7061088; rs12689868; rs7067027; rs3027448; rs12558614; rs7057957; rs1040398; rs1040400; rs3027435; rs1181252; rs1040399; rs3027434; rs17852046; rs12850496; rs12845773; rs17856663; rs12845783; rs5952696; rs3191382; rs1181251; rs35285191; rs1051000; rs1803940; rs3027438; rs1051003; rs1050990; rs4339787; rs28530533; rs3027468; rs5952754; rs5952690; rs12558961; rs12852985; rs34468176; rs2311012; rs5905428; rs34165496; rs34825602; rs7892394; rs5952812; rs11091124; rs5906017; rs28522648; rs5952677; rs11282093; rs5906045; rs3838196; rs3027455; rs28667959; rs3027463; rs35676271; rs12841775; rs35574902; rs3027447; rs28657720; rs6610848; rs28531879; rs4824563; rs6610854; rs7060566; rs12396954; rs3027469; rs35687186; rs5952736; rs35375952; rs7057164; rs34716997; rs7062993; rs7063171; rs11412800; rs6651629; rs12845848; rs12853563; rs12012179; rs28368734; rs12115950; rs35968321; rs3027460; rs12394356; rs35439218; rs36085366; rs34265248; rs35762562; rs2239451; rs34292051; rs3027445; rs11320541; rs10481834; rs12845568; rs4592179; rs3216388; rs34945383; rs34220802; rs6610855; rs34261731; rs28485908; rs7888867; rs11431011; rs4071606; rs12390352; rs10567219; rs35520175; rs28527225; rs36068670; rs5952687; rs7888857; rs5952777; rs34822523; rs12010683; rs7883563; rs5952814; rs36209687; rs5952751; rs2238970; rs5952744; rs35797631; rs12389578; rs7474005; rs3027465; rs5952768; rs5906031; rs28636832; rs34252524; rs7058426; rs12391346; rs12689072; rs35943983; rs12395246; rs11414517; rs3027467; rs12013925; rs3736671; rs28421767; rs7058949; rs35634965; rs28754429; rs1894610; rs36102775; rs9887081; rs5952817; rs12855578; rs10658111; rs7062575; rs4620438; rs28568938; rs35291347; rs11797733; rs35054600; rs5952335; rs3027462; rs5952712; rs34752122; rs3054011; rs3027437; rs28577261; rs3027433; rs3761584; rs3027436; rs3027432; rs12558036; rs3027418; rs3027419; rs3027420; rs3027421; rs3027423; rs3027424; rs3027425; rs3027426; rs3027427; rs3027428; rs3027429; rs3027430; rs3027431; rs4351544; rs7884135; rs7890899

# Metabolic_Enzyme_2_General_References:
2023912; 3387449; 8515265; 1432104; 11049757; 11753429

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5631

# Metabolic_Enzyme_3_Name:
Retina-specific copper amine oxidase precursor

# Metabolic_Enzyme_3_Synonyms:
RAO; Amine oxidase [copper-containing]

# Metabolic_Enzyme_3_Gene_Name:
AOC2

# Metabolic_Enzyme_3_Protein_Sequence:
>Retinaspecific copper amine oxidase precursor
MHLKIVLAFLALSLITIFALAYVLLTSPGGSSQPPHCPSVSHRAQPWPHPGQSQLFADLS
REELTAVMRFLTQRLGPGLVDAAQAQPSDNCIFSVELQLPPKAAALAHLDRGSPPPAREA
LAIVLFGGQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLRAEFTQMWRHLK
EVELPKAPIFLSSTFNYNGSTLAAVHATPRGLRSGDRATWMALYHNISGVGLFLHPVGLE
LLLDHRALDPAHWTVQQVFYLGHYYADLGQLEREFKSGRLEVVRVPLPPPNGASSLRSRN
SPGPLPPLQFSPQGSQYSVQGNLVVSSLWSFTFGHGVFSGLRIFDVRFQGERIAYEVSVQ
ECVSIYGADSPKTMLTRYLDSSFGLGRNSRGLVRGVDCPYQATMVDIHILVGKGAVQLLP
GAVCVFEEAQGLPLRRHHNYLQNHFYGGLASSALVVRSVSSVGNYDYIWDFVLYPNGALE
GRVHATGYINTAFLKGGEEGLLFGNRVGERVLGTVHTHAFHFKLDLDVAGLKNWVVAEDV
VFKPVAAPWNPEHWLQRPQLTRQVLGKEDLTAFSLGSPLPRYLYLASNQTNAWGHQRGYR
IQIHSPLGIHIPLESDMERALSWGRYQLVVTQRKEEESQSSSIYHQNDIWTPTVTFADFI
NNETLLGEDLVAWVTASFLHIPHAEDIPNTVTLGNRVGFLLRPYNFFDEDPSIFSPGSVY
FEKGQDAGLCSINPVACLPDLAACVPDLPPFSYHGF

# Metabolic_Enzyme_3_Number_of_Residues:
756

# Metabolic_Enzyme_3_Molecular_Weight:
83674

# Metabolic_Enzyme_3_Theoretical_pI:
7.03

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_3_Specific_Function:
May be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine

# Metabolic_Enzyme_3_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_3_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_3_Signals:
1-32

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1906806

# Metabolic_Enzyme_3_SwissProt_ID:
AOC2_HUMAN (O75106)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
AOC2

# Metabolic_Enzyme_3_Geneatlas_id:
AOC2

# Metabolic_Enzyme_3_hgnc_id:
HGNC:549

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Membrane

# Metabolic_Enzyme_3_Gene_Sequence:
>2190 bp
ATGCATCTCAAGATAGTCCTGGCGTTCCTGGCACTGTCCCTCATTACCATCTTTGCCCTG
GCCTATGTTTTGCTGACCAGCCCAGGTGGTTCCAGCCAGCCTCCCCACTGCCCCTCTGTA
TCCCATAGGGCCCAGCCCTGGCCACACCCTGGCCAGAGCCAGCTGTTTGCAGACCTGAGC
CGAGAGGAGTTGACAGCTGTGATGCGCTTTCTGACCCAGCGGCTGGGGCCAGGGCTGGTG
GACGCAGCCCAGGCTCAGCCCTCGGACAACTGCATCTTCTCAGTGGAGCTGCAGCTGCCC
CCCAAGGCTGCAGCCCTGGCCCACCTGGACAGGGGGAGCCCCCCACCTGCCCGGGAGGCA
CTGGCCATCGTCCTCTTTGGTGGACAACCCCAACCCAATGTGAGTGAGCTGGTGGTGGGG
CCGCTGCCTCACCCCTCGTACATGCGGGATGTGACTGTGGAGCGTCACGGCGGGCCCCTG
CCCTATCACCGTCGCCCGGTGCTGAGAGCTGAGTTTACACAGATGTGGAGGCATCTGAAA
GATGTGGAGCTACCCAAGGCACCCATCTTCCTGTCGTCCACCTTCAACTACAATGGCTCT
ACCCTGGCAGCTGTGCATGCCACCCCTCGGGGCTTGCGCTCAAGGGAACGAACTACCTGG
ATTGGCCTCTACCATAACATCTCAGGGGTTGGTCTTTTCCTTCACCCCGTGGGGCTGGAG
CTACTACTGGACCACAGGGCCCTGGACCCTGCCCACTGGACTGTCCAGCAGGTCTTCTAC
CTTGGGCACTACTATGCAGACTTGGGCCAGTTGGAACGGGAGTTTAAGTCTGGCCGGTTG
GAAGTGGTTAGAGTCCCTCTACCTCCACCAAATGGAGCTTCATCCCTGAGGTCTCGGAAC
TCTCCAGGTCCTCTTCCCCCTCTTCAGTTCTCGCCCCAGGGTTCCCAGTACAGTGTGCAA
GGAAACCTGGTGGTATCCTCCCTCTGGTCATTTACCTTTGGCCATGGGGTGTTCAGCGGC
CTGAGGATTTTTGATGTTCGGTTCCAGGGTGAGCGAATAGCCTATGAAGTCAGTGTCCAG
GAGTGTGTATCTATCTATGGTGCCGATTCACCCAAGACGATGCTGACTCGCTATTTGGAT
AGCAGCTTTGGACTCGGCCGTAACAGCCGAGGCTTGGTGCGGGGAGTGGACTGCCCCTAT
CAAGCCACGATGGTGGACATCCATATATTAGTGGGCAAAGGGGCAGTCCAGCTGCTTCCA
GGGGCTGTGTGTGTATTTGAGGAAGCCCAGGGACTGCCCCTTCGAAGGCACCACAATTAC
CTTCAAAATCATTTCTATGGTGGTTTGGCCAGCTCAGCCCTTGTGGTCAGGTCTGTGTCA
TCTGTGGGCAACTATGACTACATTTGGGACTTTGTGTTGTACCCAAATGGGGCACTTGAA
GGGCGGGTCCATGCCACGGGTTATATCAACACAGCTTTCCTGAAAGGGGGAGAGGAGGGC
CTCCTCTTTGGGAACCGTGTGGGGGAAAGAGTGCTGGGAACGGTGCACACACATGCCTTC
CACTTCAAGCTGGACCTGGATGTGGCAGGGCTGAAAAACTGGGTGGTAGCTGAAGACGTG
GTGTTTAAACCTGTGGCTGCCCCCTGGAACCCGGAGCACTGGCTACAGCGCCCACAGCTG
ACTCGGCAGGTCCTGGGAAAGGAGGACCTGACAGCTTTTTCCTTGGGAAGCCCCCTACCC
CGCTACCTCTACCTGGCTAGCAACCAGACTAATGCGTGGGGTCACCAGCGCGGATACCAG
CTTGTGGTGACCCAGAGAAAGGAGGAGGAGTCACAGAGCAGTAGCATCTATCACCAGAAT
GACATCTGGACACCCACAGTTACCTTTGCTGACTTCATCAACAATGAAACCCTCTTAGGA
GAGGATCTGGTGGCTTGGGTCACAGCCAGCTTCCTGCACATTCCCCATGCCGAGGACATC
CCAAACACAGTGACTCTGGGGAACAGAGTTGGCTTCTTGCTCCGACCCTATAACTTCTTT
GATGAGGACCCCTCCATCTTCTCCCCTGGCAGTGTGTACTTTGAGAAGGGCCAGGATGCT
GGGCTCTGCAGCATCAATCCTGTGGCCTGCCTCCCCGACCTGGCAGCCTGTGTCCCGGAC
TTACCCCCTTTCTCTTACCACGGCTTCTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
D88213

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
9119395; 9722954

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5401

# Metabolic_Enzyme_4_Name:
Amine oxidase [flavin-containing] A

# Metabolic_Enzyme_4_Synonyms:
Monoamine oxidase type A; MAO-A

# Metabolic_Enzyme_4_Gene_Name:
MAOA

# Metabolic_Enzyme_4_Protein_Sequence:
>Amine oxidase flavincontaining 
AMENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEH
VDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPI
AYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVN
INVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVK
LNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLP
MGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKAD
RLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQY
GRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESK
DVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS

# Metabolic_Enzyme_4_Number_of_Residues:
527

# Metabolic_Enzyme_4_Molecular_Weight:
59682

# Metabolic_Enzyme_4_Theoretical_pI:
7.96

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine

# Metabolic_Enzyme_4_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_4_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01593:Amino_oxidase

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
498-518

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.4.3.4

# Metabolic_Enzyme_4_GenBank_ID_Protein:
187353

# Metabolic_Enzyme_4_SwissProt_ID:
AOFA_HUMAN (P21397)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
MAOA

# Metabolic_Enzyme_4_Geneatlas_id:
MAOA

# Metabolic_Enzyme_4_hgnc_id:
HGNC:6833

# Metabolic_Enzyme_4_PDB_ID:
1O5W

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type IV membrane protein; cytoplasmic side

# Metabolic_Enzyme_4_Gene_Sequence:
>1584 bp
ATGGAGAATCAAGAGAAGGCGAGTATCGCGGGCCACATGTTCGACGTAGTCGTGATCGGA
GGTGGCATTTCAGGACTATCTGCTGCCAAACTCTTGACTGAATATGGCGTTAGTGTTTTG
GTTTTAGAAGCTCGGGACAGGGTTGGAGGAAGAACATATACTATAAGGAATGAGCATGTT
GATTACGTAGATGTTGGTGGAGCTTATGTGGGACCAACCCAAAACAGAATCTTACGCTTG
TCTAAGGAGCTGGGCATAGAGACTTACAAAGTGAATGTCAGTGAGCGTCTCGTTCAATAT
GTCAAGGGGAAAACATATCCATTTCGGGGCGCCTTTCCACCAGTATGGAATCCCATTGCA
TATTTGGATTACAATAATCTGTGGAGGACAATAGATAACATGGGGAAGGAGATTCCAACT
GATGCACCCTGGGAGGCTCAACATGCTGACAAATGGGACAAAATGACCATGAAAGAGCTC
ATTGACAAAATCTGCTGGACAAAGACTGCTAGGCGGTTTGCTTATCTTTTTGTGAATATC
AATGTGACCTCTGAGCCTCACGAAGTGTCTGCCCTGTGGTTCTTGTGGTATGTGAAGCAG
TGCGGGGGCACCACTCGGATATTCTCTGTCACCAATGGTGGCCAGGAACGGAAGTTTGTA
GGTGGATCTGGTCAAGTGAGCGAACGGATAATGGACCTCCTCGGAGACCAAGTGAAGCTG
AACCATCCTGTCACTCACGTTGACCAGTCAAGTGACAACATCATCATAGAGACGCTGAAC
CATGAACATTATGAGTGCAAATACGTAATTAATGCGATCCCTCCGACCTTGACTGCCAAG
ATTCACTTCAGACCAGAGCTTCCAGCAGAGAGAAACCAGTTAATTCAGCGGCTTCCAATG
GGAGCTGTCATTAAGTGCATGATGTATTACAAGGAGGCCTTCTGGAAGAAGAAGGATTAC
TGTGGCTGCATGATCATTGAAGATGAAGATGCTCCAATTTCAATAACCTTGGATGACACC
AAGCCTGATGGGTCACTGCCTGCCATCATGGGCTTCATTCTTGCCCGGAAAGCTGATCGA
CTTGCTAAGCTACATAAGGAAATAAGGAAGAAGAAAATCTGTGAGCTCTATGCCAAAGTG
CTGGGATCCCAAGAAGCTTTACATCCAGTGCATTATGAAGAGAAGAACTGGTGTGAGGAG
CAGTACTCTGGGGGCTGCTACACGGCCTACTTCCCTCCTGGGATCATGACTCAATATGGA
AGGGTGATTCGTCAACCCGTGGGCAGGATTTTCTTTGCGGGCACAGAGACTGCCACAAAG
TGGAGCGGCTACATGGAAGGGGCAGTTGAGGCTGGAGAACGAGCAGCTAGGGAGGTCTTA
AATGGTCTCGGGAAGGTGACCGAGAAAGATATCTGGGTACAAGAACCTGAATCAAAGGAC
GTTCCAGCGGTAGAAATCACCCACACCTTCTGGGAAAGGAACCTGCCCTCTGTTTCTGGC
CTGCTGAAGATCATTGGATTTTCCACATCAGTAACTGCCCTGGGGTTTGTGCTGTACAAA
TACAAGCTCCTGCCACGGTCTTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M68840

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_4_Locus:
Xp11.3

# Metabolic_Enzyme_4_SNPs:
rs6323; rs1137070; rs1800464; rs3027407; rs2072743; rs1465107; rs979605; rs3027397; rs2205718; rs979606; rs909525; rs3788862; rs2283725; rs2235186; rs5906883; rs5906974; rs3027403; rs3027405; rs6520894; rs3027401; rs3788863; rs2235185; rs1465108; rs5953385; rs2310883; rs6609250; rs3027398; rs5906938; rs5906729; rs6520897; rs5906893; rs17146683; rs7885398; rs3027402; rs5905702; rs5906957; rs2072744; rs5906915; rs4824498; rs9723729; rs3027406; rs5906973; rs3027400; rs2064697; rs5906914; rs5906901; rs12689575; rs2239448; rs2064696; rs3027392; rs2238968; rs17146660; rs12688067; rs9723711; rs7051042; rs5905859; rs7887158; rs2064698; rs7882699; rs3027399; rs9330645; rs2283724; rs9723795; rs3027404; rs9724332; rs5953210; rs1803986; rs1799835; rs1800466; rs1803987; rs1800465; rs7065428; rs3027408; rs11544798; rs12839550; rs10545588; rs5952250; rs3027394; rs34390290; rs1800659; rs10560402; rs12854463; rs35759188; rs28375424; rs7059300; rs12687961; rs35784967; rs35254233; rs34894015; rs35215664; rs35546327; rs3027396; rs12556694; rs7057038; rs12687974; rs9780693; rs7892282; rs5902323; rs28593700; rs35600375; rs35488042; rs35200424; rs5902326; rs5905823; rs12843650; rs34941362; rs34841794; rs12833632; rs12863636; rs3030071; rs12398290; rs10548364; rs28401570; rs4604608; rs28449781; rs6609256; rs6610845; rs12833929; rs12843268; rs2310884; rs5905830; rs6610846; rs7054032; rs7880230; rs41303697; rs3810709; rs2179098; rs12399572; rs12840448; rs5902324; rs28556796; rs5905812; rs12847449; rs28619059; rs10652560; rs6610837; rs10548363; rs5905418; rs2283726; rs33910552; rs3027395; rs28637527; rs5906971; rs28439389; rs35235270; rs3027393; rs28583596; rs6610842; rs6520893; rs35336176; rs5906913; rs12849959; rs36036121; rs5905822; rs5902325; rs5905809; rs11471949; rs6610834; rs3838195; rs3216387; rs33946653; rs6609255; rs35445276; rs7061874; rs17436054; rs1181275; rs12843533; rs2064070; rs3027409; rs3027410; rs3027414; rs3027415; rs3027416; rs3027417; rs4301558; rs4570308; rs5905613; rs6609257; rs6609258; rs7052785; rs727884

# Metabolic_Enzyme_4_General_References:
3418353; 3387449; 1432104; 8584674; 7519662; 3178846; 2764901; 11812236

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5627

# Metabolic_Enzyme_5_Name:
Amiloride-sensitive amine oxidase [copper-containing] precursor

# Metabolic_Enzyme_5_Synonyms:
Diamine oxidase; DAO; Amiloride-binding protein; ABP; Histaminase; Kidney amine oxidase; KAO

# Metabolic_Enzyme_5_Gene_Name:
ABP1

# Metabolic_Enzyme_5_Protein_Sequence:
>Amiloridesensitive amine oxidase coppercontaining precursor
MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS
TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP
GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR
CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG
KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP
RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG
GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE
MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH
ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT
NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSM
ADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWDPPVVFEQFLHNNENI
ENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRD
NGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV

# Metabolic_Enzyme_5_Number_of_Residues:
751

# Metabolic_Enzyme_5_Molecular_Weight:
85342

# Metabolic_Enzyme_5_Theoretical_pI:
7.01

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_5_Specific_Function:
Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function

# Metabolic_Enzyme_5_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_5_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_5_Signals:
1-19

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_5_GenBank_ID_Protein:
177960

# Metabolic_Enzyme_5_SwissProt_ID:
ABP1_HUMAN (P19801)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ABP1

# Metabolic_Enzyme_5_Geneatlas_id:
ABP1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:80

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_5_Gene_Sequence:
>2142 bp
ATGCCGGCCCTGGGCTGGGCCGTGGCTGCCATCCTGATGCTGCAGACGGCCATGGCGGAG
CCCTCCCCGGGGACTCTGCCCAGGAAGGCAGGGGTGTTTTCAGACCTAAGCAACCAAGAG
CTGAAGGCAGTGCACAGCTTCCTCTGGTCCAAGAAGGAGCTGAGGCTGCAGCCCTCCAGT
ACCACCACCATGGCCAAGAACACCGTGTTTCTCATCGAGATGCTGCTGCCCAAGAAGTAC
CATGTGCTGAGGTTTCTGGATAAAGGTGAAAGGCATCCTGTGCGGGAAGCCCGTGCCGTC
ATCTTCTTTGGTGACCAGGAGCATCCCAATGTCACCGAGTTTGCTGTGGGGCCCCTGCCA
GGGCCCTGCTACATGCGAGCACTGTCCCCCAGGCCTGGGTACCAGTCCTCCTGGGCATCG
AGGCCCATCTCCACAGCAGAGTATGCCCTCCTCTACCACACCCTGCAGGAAGCCACCAAG
CCCCTGCATCAGTTCTTCCTCAATACCACAGGCTTCTCATTCCAAGACTGCCATGACAGA
TGCCTGGCCTTCACCGATGTGGCCCCCCGGGGTGTGGCTTCTGGCCAGCGCCGCAGTTGG
CTTATCATACAGCGCTATGTAGAAGGCTACTTTCTGCACCCCACTGGGCTGGAGCTCCTC
GTGGATCATGGGAGCACAGATGCTGGGCACTGGGCCGTGGAGCAGGTGTGGTACAACGGG
AAGTTCTATGGGAGCCCAGAGGAACTGGCACGGAAGTATGCAGATGGAGAGGTGGACGTG
GTGGTCCTGGAGGACCGCTGCCTGGGGGCAAGGGGCATGACAGCACAGAGGAGCCGGCCC
TCTTCTCCTCCACAAGCCCCGCGGGACTTTCCCCAGCCCCATCCATGTGAGCGGCCCCCG
CTTGGTCCAGCCCCACGGCCCTCGCTTCAGGCTGGAGGGCAACGCTGTGCTCTACGGCGG
CTGGAGCTTTGCCTTCCGGTGCGCTCCTCCTCCGGGCTGCAGGTCCTGAACGTGCACTTC
GGCGGAGAGCGCATTGCCTATGAGGTCAGCGTGCAAGAGGCAGTGGCGCTGTATGGAGGA
CACACACCTGCAGGCATGCAGACCAAGTACCTCGATGTCGGCTGGGGCCTGGGCAGCGTC
ACTCATGAGTTAGCCCCCGGCATCGACTGCCCGGAGACCGCCACCTTCCTGGACACTTTC
CACTACTATGATGCCGATGACCCGGTCCATTATCCCCGAGCCCTCTGCCTCTTTGAAATG
CCCACAGGGGTGCCCCTTCGGCGGCACTTTAATTCCAACTTTAAAGGTGGCTTCAACTTC
TATGCAGGGCTGAAGGGCCAGGTGCTGGTGCTGCGGACAACTTCAACTGTCTACAATTAT
GATTACATTTGGGACTTTATCTTCTACCCCAACGGGGTGATGGAGGCCAAGATGCATGCC
ACTGGCTACGTCCACGCCACCTTCTACACCCCCGAGGGCTGCGCACGGCACTCGCCTGCA
CACCCACCTGATTGGCAACATACACACTCACTTGTGCACTACCGCGTAGACCTGGATGTG
GCAGGCACCAAGAACAGCTTCCAGACACTGCAGATGAAGCTAGAAAACATCACCAACCCC
TGGAGCCCGAGACACCGCGTGGTCCAGCCAACTCTGGAGCAGACGCAGTACTCCTGGGAG
CGCCAGGCGGCCTTCCGCTTCAAAAGGAGGCTGCCCAAGTACCTGCTCTTTACCAGCCCC
CAGGAGAACCCCTGGGGCCACAAGCGCAGCTACCGCCTGCAGATCCACTCCATGGCCGAC
CAGGTGCTGCCCCCAGGCTGGCAGGAGGAGCAGGCCATCACCTGGGCAAGGTACCCCCTG
GCAGTGACCAAGTACCGGGAGTCAGAGCTGTGCAGCAGCAGCATCTACCACCAGAACGAC
CCCTGGGACCCGCCCGTGGTCTTTGAGCAGTTTCTTCACAACAACGAGAACATTGAAAAT
GAGGACCTGGTGGCCTGGGTGACGGTGGGCTTCCTGCACATCCCCCACTCAGAGGACATT
CCCAACACAGCCACACCTGGGAACTCCGTGGGCTTCCTGCTCCGGCCATTCAACTTCTTC
CCAGAGGACCCCTCCCCTCCCTGGCATCCAGAGACACTGTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M55602

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_5_Locus:
7q34-q36

# Metabolic_Enzyme_5_SNPs:
rs10156191; rs1049742; rs35070995; rs1049793; rs1049748; rs10893; rs2071514; rs4725373; rs10441169; rs2268998; rs2071513; rs10156189; rs2268999; rs7786439; rs12539; rs12540862; rs11771771; rs2071515; rs11981415; rs11981217; rs3735076; rs10952294; rs4725968; rs2301257; rs2373876; rs10273373; rs2052130; rs2052129; rs2071517; rs17173645; rs2301256; rs4725375; rs4725970; rs35929142; rs6943147; rs41465145; rs6943420; rs10441176; rs7787074; rs7786420; rs7786526; rs35730790; rs10281706; rs35773682; rs8180720; rs13235597; rs13235592; rs13235484; rs34532106; rs4725969; rs4725374; rs4431514; rs35724462; rs10273148; rs34459590; rs34090933; rs35411492; rs34502771; rs1005389; rs1005390; rs10230025; rs10236489; rs10240738; rs10249948; rs10250599; rs10250704; rs10254616; rs10254802; rs10268640; rs11760854; rs11771001; rs11971392; rs11976328; rs11978239; rs12374688; rs12374823; rs12375106; rs1476867; rs2215563; rs2215564; rs4725376; rs4725377; rs4725971; rs6977081; rs6977381; rs7793572; rs7798657; rs887587; rs887588

# Metabolic_Enzyme_5_General_References:
2217167; 8182053; 8595053; 8144586

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
6060

# Metabolic_Enzyme_6_Name:
Alcohol dehydrogenase class 3

# Metabolic_Enzyme_6_Synonyms:
Alcohol dehydrogenase class III; Alcohol dehydrogenase class chi chain; S-; hydroxymethylglutathione dehydrogenase; Glutathione- dependent formaldehyde dehydrogenase; FDH

# Metabolic_Enzyme_6_Gene_Name:
ADH5

# Metabolic_Enzyme_6_Protein_Sequence:
>Alcohol dehydrogenase class 3
MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGC
FPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGK
GLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGY
GAAVNTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATEC
INPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEE
IATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFE
LMHSGKSIRTVVKI

# Metabolic_Enzyme_6_Number_of_Residues:
374

# Metabolic_Enzyme_6_Molecular_Weight:
39725

# Metabolic_Enzyme_6_Theoretical_pI:
7.54

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_6_Specific_Function:
Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione

# Metabolic_Enzyme_6_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00350  Tyrosine metabolism;
 map00561  Glycerolipid metabolism;
 map00624  1- and 2-Methylnaphthalene degradation

# Metabolic_Enzyme_6_Reaction:
an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF08240:ADH_N;
PF00107:ADH_zinc_N

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.1.1.1;EC 1.1.1.284

# Metabolic_Enzyme_6_GenBank_ID_Protein:
178134

# Metabolic_Enzyme_6_SwissProt_ID:
ADHX_HUMAN (P11766)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ADH5

# Metabolic_Enzyme_6_Geneatlas_id:
ADH5

# Metabolic_Enzyme_6_hgnc_id:
HGNC:253

# Metabolic_Enzyme_6_PDB_ID:
1MC5

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_6_Gene_Sequence:
>1125 bp
ATGGCGAACGAGGTTATCAAGTGCAAGGCTGCAGTTGCTTGGGAGGCTGGAAAGCCTCTC
TCCATAGAGGAGATAGAGGTGGCACCCCCAAAGGCTCATGAAGTTCGAATCAAGATCATT
GCCACTGCGGTTTGCCACACCGATGCCTATACCCTGAGTGGAGCTGATCCTGAGGGTTGT
TTTCCAGTGATCTTGGGACATGAAGGTGCTGGAATTGTGGAAAGTGTTGGTGAGGGAGTT
ACTAAGCTGAAGGCGGGTGACACTGTCATCCCACTTTACATCCCACAGTGTGGAGAATGC
AAATTTTGTCTAAATCCTAAAACTAACCTTTGCCAGAAGATAAGAGTCACTCAAGGGAAA
GGATTAATGCCAGATGGTACCAGCAGATTTACTTGCAAAGGAAAGACAATTTTGCATTAC
ATGGGAACCAGCACATTTTCTGAATACACAGTTGTGGCTGATATCTCTGTTGCTAAAATA
GATCCTTTAGCACCTTTGGATAAAGTCTGCCTTCTAGGTTGTGGCATTTCAACCGGTTAT
GGTGCTGCTGTGAACACTGCCAAGTTGGAGCCTGGCTCTGTTTGTGCCGTCTTTGGTCTG
GGAGGAGTCGGATTGGCAGTTATCATGGGCTGTAAAGTGGCTGGTGCTTCCCGGATCATT
GGTGTGGACATCAATAAAGATAAATTTGCAAGGGCCAAAGAGTTTGGAGCCACTGAATGT
ATTAACCCTCAGGATTTTAGTAAACCCATCCAGGAAGTGCTCATTGAGATGACCGATGGA
GGAGTGGACTATTCCTTTGAATGTATTGGTAATGTGAAGGTCATGAGAGCAGCACTTGAG
GCATGTCACAAGGGCTGGGGCGTCAGCGTCGTGGTTGGAGTAGCTGCTTCAGGTGAAGAA
ATTGCCACTCGTCCATTCCAGCTGGTAACAGGTCGCACATGGAAAGGCACTGCCTTTGGA
GGATGGAAGAGTGTAGAAAGTGTCCCAAAGTTGGTGTCTGAATATATGTCCAAAAAGATA
AAAGTTGATGAATTTGTGACTCACAATCTGTCTTTTGATGAAATCAACAAAGCCTTTGAA
CTGATGCATTCTGGAAAGAGCATTCGAACTGTTGTAAAGATTTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M30471

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_6_Locus:
4q21-q25

# Metabolic_Enzyme_6_SNPs:
rs16996593; rs28730623; rs28730643; rs7669660; rs1803037; rs13832; rs11568816; rs6827292; rs12106; rs11547772; rs28730650; rs1061187; rs28730645; rs28730646; rs17028487; rs12697; rs28730649; rs1154410; rs7683802; rs896992; rs1154411; rs1154405; rs6846829; rs7683704; rs1154401; rs1154414; rs17028505; rs17028500; rs7658279; rs4699701; rs4699700; rs7688859; rs6852848; rs7658127; rs7658118; rs7666867; rs3018048; rs7688835; rs7688531; rs13109048; rs7688686; rs4699699; rs1154412; rs17595424; rs28730592; rs28730605; rs28894371; rs1154415; rs28730639; rs13145727; rs28985868; rs28730576; rs28730607; rs28730581; rs28730569; rs28730624; rs1154404; rs28730641; rs28730597; rs28730601; rs28730578; rs28730590; rs28730575; rs1154409; rs1154402; rs13118409; rs28730612; rs29001350; rs28730632; rs28730571; rs29001346; rs28730603; rs28730594; rs29001583; rs28730596; rs29001348; rs28730582; rs28730620; rs28730619; rs28730637; rs13127586; rs28730608; rs28730568; rs28730640; rs28894370; rs28730600; rs28730630; rs13146416; rs28730644; rs28730625; rs28730617; rs1154416; rs29001345; rs28730610; rs28730584; rs28730602; rs9799556; rs13125919; rs28730636; rs28730587; rs28730621; rs29001347; rs28730573; rs28730611; rs28730593; rs28730595; rs28730627; rs29001351; rs35123946; rs2866033; rs28730613; rs28730629; rs1154403; rs13119035; rs28730589; rs11934304; rs29001349; rs28730631; rs28730591; rs29001631; rs28730604; rs28730570; rs7684735; rs7679102; rs1154400; rs7684986; rs17216887; rs7662987; rs7667261; rs2602899; rs29001338; rs29001341; rs28730655; rs29001336; rs1230158; rs13132688; rs29001339; rs17028482; rs2851301; rs28987121; rs29001340; rs1050636; rs1050637; rs28730628; rs28730652; rs28730653; rs28730648; rs29001343; rs1803038; rs28730647; rs28730651; rs28730583; rs28730599; rs33990814; rs34370152; rs1154406; rs34443372; rs28730606; rs28730616; rs28730586; rs34609488; rs34912906; rs11317364; rs28730585; rs35796474; rs28730618; rs28730634; rs28730626; rs28730572; rs28894372; rs1154413; rs5860558; rs34470866; rs28730622; rs28730635; rs29001344; rs28730598; rs35169500; rs28894368; rs6148593; rs34594585; rs29001542; rs28730588; rs28730609; rs28730577; rs28730633; rs28730615; rs28730580; rs29001570; rs3805321; rs33981706; rs1154407; rs1235433; rs28730574; rs34763643; rs36160699; rs34146172; rs3792680; rs10618658; rs28730638; rs35904284; rs13133011; rs34452464; rs1154408; rs33972516; rs28730656; rs1048578; rs29001342; rs10582873; rs3974877; rs28730657; rs36093781; rs1048577; rs5860559; rs10560641; rs11455235; rs10616090; rs35101663; rs35815329; rs11553737; rs29001335; rs28730658; rs11292055; rs34834932; rs2187482; rs10587720; rs34985976; rs1130076; rs34439422; rs28730654; rs29001337; rs10006953; rs1230154; rs1230155; rs1230157; rs1230164; rs1230165; rs1238741; rs1311615; rs1311616; rs1311617; rs1311621; rs13120000; rs1312200; rs1473371; rs15193; rs17028473; rs17595102; rs17595186; rs2602836; rs2851286; rs28730614; rs2924584; rs7664906; rs7667424; rs7681427; rs7687322

# Metabolic_Enzyme_6_General_References:
2818582; 2679557; 1446828; 3365377; 8494891; 8460164; 9018047

# Metabolic_Enzyme_6_References:
11038276; 15480576; 8037683

# Metabolic_Enzyme_7_ID:
5943

# Metabolic_Enzyme_7_Name:
Glutamine synthetase

# Metabolic_Enzyme_7_Synonyms:
Glutamate--ammonia ligase; GS

# Metabolic_Enzyme_7_Gene_Name:
GLUL

# Metabolic_Enzyme_7_Protein_Sequence:
>Glutamine synthetase
MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEW
NFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRI
MDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHY
RACLYAGVKIAGTNAEVMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDP
KPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRL
TGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCL
LNETGDEPFQYKN

# Metabolic_Enzyme_7_Number_of_Residues:
373

# Metabolic_Enzyme_7_Molecular_Weight:
42065

# Metabolic_Enzyme_7_Theoretical_pI:
6.88

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  acid-ammonia (or amide) ligase activity
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  acid-ammonia (or amide) ligase activity
Function:  ammonia ligase activity
Function:  glutamate-ammonia ligase activity
 ||
>>>
Process:  nitrogen compound metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
Process:  glutamine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine

# Metabolic_Enzyme_7_Pathway:
map00251  Glutamate metabolism;
 map00550  Peptidoglycan biosynthesis;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_7_Reaction:
ATP + L-glutamate + ammonia = ADP + phosphate + L-glutamine

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00120:Gln-synt_C;
PF03951:Gln-synt_N

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 6.3.1.2

# Metabolic_Enzyme_7_GenBank_ID_Protein:
31833

# Metabolic_Enzyme_7_SwissProt_ID:
GLNA_HUMAN (P15104)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
GLUL

# Metabolic_Enzyme_7_Geneatlas_id:
GLUL

# Metabolic_Enzyme_7_hgnc_id:
HGNC:4341

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_7_Gene_Sequence:
>1122 bp
ATGACCACCTCAGCAAGTTCCCACTTAAATAAAGGCATCAAGCAGGTGTACATGTCCCTG
CCTCAGGGTGAGAAAGTCCAGGCCATGTATATCTGGATCGATGGTACTGGAGAAGGACTG
CGCTGCAAGACCCGGACCCTGGACAGTGAGCCCAAGTGTGTGGAAGAGTTGCCTGAGTGG
AATTTCGATGGCTCCAGTACTTTACAGTCTGAGGGTTCCAACAGTGACATGTATCTCGTG
CCTGCTGCCATGTTTCGGGACCCCTTCCGTAAGGACCCTAACAAGCTGGTGTTATGTGAA
GTTTTCAAGTACAATCGAAGGCCTGCAGAGACCAATTTGAGGCACACCTGTAAACGGATA
ATGGACATGGTGAGCAACCAGCACCCCTGGTTTGGCATGGAGCAGGAGTATACCCTCATG
GGGACAGATGGGCACCCCTTTGGTTGGCCTTCCAACGGCTTCCCAGGGCCCCAGGGTCCA
TATTACTGTGGTGTGGGAGCAGACAGAGCCTATGGCAGGGACATCGTGGAGGCCCATTAC
CGGGCCTGCTTGTATGCTGGAGTCAAGATTGCGGGGACTAATGCCGAGGTCATGCCTGCC
CAGTGGGAATTTCAGATTGGACCTTGTGAAGGAATCAGCATGGGAGATCATCTCTGGGTG
GCCCGTTTCATCTTGCATCGTGTGTGTGAAGACTTTGGAGTGATAGCAACCTTTGATCCT
AAGCCCATTCCTGGGAACTGGAATGGTGCAGGCTGCCATACCAACTTCAGCACCAAGGCC
ATGCGGGAGGAGAATGGTCTGAAGTACATCGAGGAGGCCATTGAGAAACTAAGCAAGCGG
CACCAGTACCACATCCGTGCCTATGATCCCAAGGGAGGCCTGGACAATGCCCGACGTCTA
ACTGGATTCCATGAAACCTCCAACATCAACGACTTTTCTGGTGGTGTAGCCAATCGTAGC
GCCAGCATACGCATTCCCCGGACTGTTGGCCAGGAGAAGAAGGGTTACTTTGAAGATCGT
CGCCCCTCTGCCAACTGCGACCCCTTTTCGGTGACAGAAGCCCTCATCCGCACGTGTCTT
CTCAATGAAACCGGCGATGAGCCCTTCCAGTACAAAAATTAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
Y00387

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_7_Locus:
1q31

# Metabolic_Enzyme_7_SNPs:
rs1058111; rs912900; rs9347; rs912901; rs4075941; rs4652704; rs7539686; rs7734; rs3895340; rs4652705; rs912902; rs12136955; rs12403634; rs4075940; rs1058788; rs16828882; rs8762; rs7543200; rs3795487; rs2296520; rs2296519; rs10494546; rs17462824; rs12735664; rs11577936; rs2296521; rs6691339; rs11577698; rs2296523; rs11577696; rs10797771; rs4652707; rs16858921; rs4652706; rs11585457; rs2296522; rs10429835; rs4517308; rs10797770; rs11541591; rs17855559; rs17852995; rs35378126; rs17852994; rs6666230; rs6684136; rs6679250; rs34809780; rs12082312; rs36115491; rs7548303; rs1058744; rs3199511; rs12757803; rs17509341; rs1058806; rs6703479; rs8527; rs1058719; rs10535077; rs4110992; rs6699943; rs35747237; rs35275813; rs35161314; rs35268520; rs10911069; rs10458354; rs34444584; rs34239448; rs12088820; rs3028837; rs35750497; rs1001403; rs10911070; rs10911071; rs11576932; rs12039934; rs12568730; rs12733426; rs12736387; rs12756106; rs17509572; rs17509621; rs1925829; rs2038891; rs2068781; rs2148030; rs4652708; rs6424853; rs6667958; rs6674281; rs6684297; rs6698722; rs7549329; rs7549498; rs7551829

# Metabolic_Enzyme_7_General_References:
2888076; 1681907; 7909780; 12387715

# Metabolic_Enzyme_7_References:
11607303; 12698794; 7891728

# Macromolecular_Interacting_Partner_1_ID:
7540

# Macromolecular_Interacting_Partner_1_Name:
Alpha-2-macroglobulin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Alpha-2-M

# Macromolecular_Interacting_Partner_1_Gene_Name:
A2M

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Alpha2macroglobulin precursor
MGKNKLLHPSLVLLLLVLLPTDASVSGKPQYMVLVPSLLHTETTEKGCVLLSYLNETVTV
SASLESVRGNRSLFTDLEAENDVLHCVAFAVPKSSSNEEVMFLTVQVKGPTQEFKKRTTV
MVKNEDSLVFVQTDKSIYKPGQTVKFRVVSMDENFHPLNELIPLVYIQDPKGNRIAQWQS
FQLEGGLKQFSFPLSSEPFQGSYKVVVQKKSGGRTEHPFTVEEFVLPKFEVQVTVPKIIT
ILEEEMNVSVCGLYTYGKPVPGHVTVSICRKYSDASDCHGEDSQAFCEKFSGQLNSHGCF
YQQVKTKVFQLKRKEYEMKLHTEAQIQEEGTVVELTGRQSSEITRTITKLSFVKVDSHFR
QGIPFFGQVRLVDGKGVPIPNKVIFIRGNEANYYSNATTDEHGLVQFSINTTNVMGTSLT
VRVNYKDRSPCYGYQWVSEEHEEAHHTAYLVFSPSKSFVHLEPMSHELPCGHTQTVQAHY
ILNGGTLLGLKKLSFYYLIMAKGGIVRTGTHGLLVKQEDMKGHFSISIPVKSDIAPVARL
LIYAVLPTGDVIGDSAKYDVENCLANKVDLSFSPSQSLPASHAHLRVTAAPQSVCALRAV
DQSVLLMKPDAELSASSVYNLLPEKDLTGFPGPLNDQDDEDCINRHNVYINGITYTPVSS
TNEKDMYSFLEDMGLKAFTNSKIRKPKMCPQLQQYEMHGPEGLRVGFYESDVMGRGHARL
VHVEEPHTETVRKYFPETWIWDLVVVNSAGVAEVGVTVPDTITEWKAGAFCLSEDAGLGI
SSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPKCIRVSVQLEASPAFLAVPVE
KEQAPHCICANGRQTVSWAVTPKSLGNVNFTVSAEALESQELCGTEVPSVPEHGRKDTVI
KPLLVEPEGLEKETTFNSLLCPSGGEVSEELSLKLPPNVVEESARASVSVLGDILGSAMQ
NTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEVKSKAIGYLNTGYQRQLNYKH
YDGSYSTFGERYGRNQGNTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCF
RSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLTVTHPVVRNALFCLESAWKTAQEGDH
GSHVYTKALLAYAFALAGNQDKRKEVLKSLNEEAVKKDNSVHWERPQKPKAPVGHFYEPQ
APSAEVEMTSYVLLAYLTAQPAPTSEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHA
LSKYGAATFTRTGKAAQVTIQSSGTFSSKFQVDNNNRLLLQQVSLPELPGEYSMKVTGEG
CVYLQTSLKYNILPEKEEFPFALGVQTLPQTCDEPKAHTSFQISLSVSYTGSRSASNMAI
VDVKMVSGFIPLKPTVKMLERSNHVSRTEVSSNHVLIYLDKVSNQTLSLFFTVLQDVPVR
DLKPAIVKVYDYYETDEFAIAEYNAPCSKDLGNA

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
1474

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
163280

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.39

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  protease inhibitor activity
Function:  endopeptidase inhibitor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00207:A2M;
PF07678:A2M_comp;
PF01835:A2M_N;
PF07703:A2M_N_2;
PF07677:A2M_recep

# Macromolecular_Interacting_Partner_1_Signals:
1-23

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
177870

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
A2MG_HUMAN (P01023)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
A2M

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
A2M

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:7

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>4425 bp
ATGGGGAAGAACAAACTCCTTCATCCAAGTCTGGTTCTTCTCCTCTTGGTCCTCCTGCCC
ACAGACGCCTCAGTCTCTGGAAAACCGCAGTATATGGTTCTGGTCCCCTCCCTGCTCCAC
ACTGAGACCACTGAGAAGGGCTGTGTCCTTCTGAGCTACCTGAATGAGACAGTGACTGTA
AGTGCTTCCTTGGAGTCTGTCAGGGGAAACAGGAGCCTCTTCACTGACCTGGAGGCGGAG
AATGACGTACTCCACTGTGTCGCCTTCGCTGTCCCAAAGTCTTCATCCAATGAGGAGGTA
ATGTTCCTCACTGTCCAAGTGAAAGGACCAACCCAAGAATTTAAGAAGCGGACCACAGTG
ATGGTTAAGAACGAGGACAGTCTGGTCTTTGTCCAGACAGACAAATCAATCTACAAACCA
GGGCAGACAGTGAAATTTCGTGTTGTCTCCATGGATGAAAACTTTCACCCCCTGAATGAG
TTGATTCCACTAGTATACATTCAGGATCCCAAAGGAAATCGCATCGCACAATGGCAGAGT
TTCCAGTTAGAGGGTGGCCTCAAGCAATTTTCTTTTCCCCTCTCATCAGAGCCCTTCCAG
GGCTCCTACAAGGTGGTGGTACAGAAGAAATCAGGTGGAAGGACAGAGCACCCTTTCACC
GTGGAGGAATTTGTTCTTCCCAAGTTTGAAGTACAAGTAACAGTGCCAAAGATAATCACC
ATCTTGGAAGAAGAGATGAATGTATCAGTGTGTGGCCTATACACATATGGGAAGCCTGTC
CCTGGACATGTGACTGTGAGCATTTGCAGAAAGTATAGTGACGCTTCCGACTGCCACGGT
GAAGATTCACAGGCTTTCTGTGAGAAATTCAGTGGACAGCTAAACAGCCATGGCTGCTTC
TATCAGCAAGTAAAAACCAAGGTCTTCCAGCTGAAGAGGAAGGAGTATGAAATGAAACTT
CACACTGAGGCCCAGATCCAAGAAGAAGGAACAGTGGTGGAATTGACTGGAAGGCAGTCC
AGTGAAATCACAAGAACCATAACCAAACTCTCATTTGTGAAAGTGGACTCACACTTTCGA
CAGGGAATTCCCTTCTTTGGGCAGGTGCGCCTAGTAGATGGGAAAGGCGTCCCTATACCA
AATAAAGTCATATTCATCAGAGGAAATGAAGCAAACTATTACTCCAATGCTACCACGGAT
GAGCATGGCCTTGTACAGTTCTCTATCAACACCACCAACGTTATGGGTACCTCTCTTACT
GTTAGGGTCAATTACAAGGATCGTAGTCCCTGTTACGGCTACCAGTGGGTGTCAGAAGAA
CACGAAGAGGCACATCACACTGCTTATCTTGTGTTCTCCCCAAGCAAGAGCTTTGTCCAC
CTTGAGCCCATGTCTCATGAACTACCCTGTGGCCATACTCAGACAGTCCAGGCACATTAT
ATTCTGAATGGAGGCACCCTGCTGGGGCTGAAGAAGCTCTCCTTTTATTATCTGATAATG
GCAAAGGGAGGCATTGTCCGAACTGGGACTCATGGACTGCTTGTGAAGCAGGAAGACATG
AAGGGCCATTTTTCCATCTCAATCCCTGTGAAGTCAGACATTGCTCCTGTCGCTCGGTTG
CTCATCTATGCTGTTTTACCTACCGGGGACGTGATTGGGGATTCTGCAAAATATGATGTT
GAAAATTGTCTGGCCAACAAGGTGGATTTGAGCTTCAGCCCATCACAAAGTCTCCCAGCC
TCACACGCCCACCTGCGAGTCACAGCGGCTCCTCAGTCCGTCTGCGCCCTCCGTGCTGTG
GACCAAAGCGTGCTGCTCATGAAGCCTGATGCTGAGCTCTCGGCGTCCTCGGTTTACAAC
CTGCTACCAGAAAAGGACCTCACTGGCTTCCCTGGGCCTTTGAATGACCAGGACGATGAA
GACTGCATCAATCGTCATAATGTCTATATTAATGGAATCACATATACTCCAGTATCAAGT
ACAAATGAAAAGGATATGTACAGCTTCCTAGAGGACATGGGCTTAAAGGCATTCACCAAC
TCAAAGATTCGTAAACCCAAAATGTGTCCACAGCTTCAACAGTATGAAATGCATGGACCT
GAAGGTCTACGTGTAGGTTTTTATGAGTCAGATGTAATGGGAAGAGGCCATGCACGCCTG
GTGCATGTTGAAGAGCCTCACACGGAGACCGTACGAAAGTACTTCCCTGAGACATGGATC
TGGGATTTGGTGGTGGTAAACTCAGCAGGGGTGGCTGAGGTAGGAGTAACAGTCCCTGAC
ACCATCACCGAGTGGAAGGCAGGGGCCTTCTGCCTGTCTGAAGATGCTGGACTTGGTATC
TCTTCCACTGCCTCTCTCCGAGCCTTCCAGCCCTTCTTTGTGGAGCTTACAATGCCTTAC
TCTGTGATTCGTGGAGAGGCCTTCACACTCAAGGCCACGGTCCTAAACTACCTTCCCAAA
TGCATCCGGGTCAGTGTGCAGCTGGAAGCCTCTCCCGCCTTCCTTGCTGTCCCAGTGGAG
AAGGAACAAGCGCCTCACTGCATCTGTGCAAACGGGCGGCAAACTGTGTCCTGGGCAGTA
ACCCCAAAGTCATTAGGAAATGTGAATTTCACTGTGAGCGCAGAGGCACTAGAGTCTCAA
GAGCTGTGTGGGACTGAGGTGCCTTCAGTTCCTGAACACGGAAGGAAAGACACAGTCATC
AAGCCTCTGTTGGTTGAACCTGAAGGACTAGAGAAGGAAACAACATTCAACTCCCTACTT
TGTCCATCAGGTGGTGAGGTTTCTGAAGAATTATCCCTGAAACTGCCACCAAATGTGGTA
GAAGAATCTGCCCGAGCTTCTGTCTCAGTTTTGGGAGACATATTAGGCTCTGCCATGCAA
AACACACAAAATCTTCTCCAGATGCCCTATGGCTGTGGAGAGCAGAATATGGTCCTCTTT
GCTCCTAACATCTATGTACTGGATTATCTAAATGAAACACAGCAGCTTACTCCAGAGGTC
AAGTCCAAGGCCATTGGCTATCTCAACACTGGTTACCAGAGACAGTTGAACTACAAACAC
TATGATGGCTCCTACAGCACCTTTGGGGAGCGATATGGCAGGAACCAGGGCAACACCTGG
CTCACAGCCTTTGTTCTGAAGACTTTTGCCCAAGCTCGAGCCTACATCTTCATCGATGAA
GCACACATTACCCAAGCCCTCATATGGCTCTCCCAGAGGCAGAAGGACAATGGCTGTTTC
AGGAGCTCTGGGTCACTGCTCAACAATGCCATAAAGGGAGGAGTAGAAGATGAAGTGACC
CTCTCCGCCTATATCACCATCGCCCTTCTGGAGATTCCTCTCACAGTCACTCACCCTGTT
GTCCGCAATGCCCTGTTTTGCCTGGAGTCAGCCTGGAAGACAGCACAAGAAGGGGACCAT
GGCAGCCATGTATATACCAAAGCACTGCTGGCCTATGCTTTTGCCCTGGCAGGTAACCAG
GACAAGAGGAAGGAAGTACTCAAGTCACTTAATGAGGAAGCTGTGAAGAAAGACAACTCT
GTCCATTGGGAGCGCCCTCAGAAACCCAAGGCACCAGTGGGGCATTTTTACGAACCCCAG
GCTCCCTCTGCTGAGGTGGAGATGACATCCTATGTGCTCCTCGCTTATCTCACGGCCCAG
CCAGCCCCAACCTCGGAGGACCTGACCTCTGCAACCAACATCGTGAAGTGGATCACGAAG
CAGCAGAATGCCCAGGGCGGTTTCTCCTCCACCCAGGACACAGTGGTGGCTCTCCATGCT
CTGTCCAAATATGGAGCCGCCACATTTACCAGGACTGGGAAGGCTGCACAGGTGACTATC
CAGTCTTCAGGGACATTTTCCAGCAAATTCCAAGTGGACAACAACAATCGCCTGTTACTG
CAGCAGGTCTCATTGCCAGAGCTGCCTGGGGAATACAGCATGAAAGTGACAGGAGAAGGA
TGTGTCTACCTCCAGACCTCCTTGAAATACAATATTCTCCCAGAAAAGGAAGAGTTCCCC
TTTGCTTTAGGAGTGCAGACTCTGCCTCAAACTTGTGATGAACCCAAAGCCCACACCAGC
TTCCAAATCTCCCTAAGTGTCAGTTACACAGGGAGCCGCTCTGCCTCCAACATGGCGATC
GTTGATGTGAAGATGGTCTCTGGCTTCATTCCCCTGAAGCCAACAGTGAAAATGCTTGAA
AGATCTAACCATGTGAGCCGGACAGAAGTCAGCAGCAACCATGTCTTGATTTACCTTGAT
AAGGTGTCAAATCAGACACTGAGCTTGTTCTTCACGGTTCTGCAAGATGTCCCAGTAAGA
GATCTCAAACCAGCCATAGTGAAAGTCTATGATTACTACGAGACGGATGAGTTTGCAATC
GCTGAGTACAATGCTCCTTGCAGCAAAGATCTTGGAAATGCTTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M11313

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_1_Locus:
12p13.3-p12.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs12425728; rs3180392; rs226405; rs669; rs226396; rs226380; rs226382; rs1805653; rs226406; rs226386; rs1805652; rs226381; rs2377682; rs1805678; rs1805664; rs226383; rs1805660; rs7980046; rs7980288; rs6487584; rs226389; rs4883213; rs7299282; rs113973; rs6487585; rs226390; rs1805659; rs1805663; rs1805651; rs226392; rs1805658; rs10492115; rs1805662; rs1805661; rs10842820; rs226407; rs2193005; rs16917971; rs6487587; rs1805686; rs1805666; rs7965790; rs7296138; rs1805654; rs7135781; rs226412; rs10842839; rs10842898; rs16917975; rs1805683; rs3759277; rs226415; rs16917969; rs226395; rs11609582; rs11613746; rs226385; rs1805657; rs226391; rs226400; rs226387; rs1805656; rs1805684; rs7955940; rs11833184; rs226384; rs1805680; rs226409; rs1805681; rs1805665; rs10771310; rs226388; rs226397; rs226393; rs12427063; rs11615143; rs12426061; rs11048789; rs10842845; rs226399; rs2193006; rs3026228; rs226394; rs7310089; rs2300148; rs1805679; rs6487581; rs3026224; rs7955497; rs226401; rs2477; rs7310167; rs2302666; rs10842847; rs3026223; rs2300147; rs7310884; rs1805682; rs11615434; rs226410; rs7971254; rs2111023; rs7310511; rs7298071; rs226403; rs1805655; rs7299600; rs1805687; rs7980228; rs3026225; rs7309361; rs226408; rs16918015; rs10842849; rs4882978; rs10743598; rs226402; rs7968640; rs3026229; rs226379; rs1805667; rs1805688; rs12309184; rs7959149; rs16918023; rs1800434; rs1800433; rs1802965; rs1049143; rs1802964; rs1049134; rs3832852; rs1802966; rs3190224; rs1130840; rs16918022; rs1049985; rs35361434; rs34554512; rs35204848; rs10635964; rs1799759; rs226398; rs11048885; rs12371817; rs35445064; rs11048925; rs35996014; rs7486284; rs34164345; rs11833893; rs7315247; rs11342140; rs34177423; rs226411; rs35946318; rs34639777; rs11464268; rs11831793; rs11452860; rs12423262; rs34803501; rs34694451; rs11048839; rs35416682; rs34300325; rs11048771; rs11384439; rs7486267; rs33919503; rs35416011; rs12306389; rs35165459; rs2889706; rs34796737; rs34377093; rs10619020; rs226414; rs34042668; rs4882979; rs5796338; rs7303415; rs12303727; rs34370223; rs3832851; rs11614368; rs3080603; rs7311048; rs11438631; rs34176052; rs226404; rs35504943; rs10657354; rs34283009; rs35904656; rs34707245; rs11379731; rs35310527; rs36153951; rs226413; rs3741853; rs34844537; rs3832850; rs12809162; rs34988919; rs35956134; rs34313615; rs35291816; rs3026226; rs35330566; rs35446178; rs3080599; rs36014075; rs34953995; rs7967997; rs3180682; rs11463805; rs34990507; rs17201863; rs11273739; rs35067486; rs34656493; rs12316559; rs34286412; rs34153518; rs1012588; rs10771307; rs10842795; rs10842914; rs11049011; rs11610855; rs11832423; rs226373; rs226375; rs226376; rs226378; rs4882976; rs4882977; rs6487574; rs7297589; rs7302725; rs7976461

# Macromolecular_Interacting_Partner_1_General_References:
2581245; 1374237; 6203908; 1692292; 1370808; 2408344; 12754519; 6195065; 6165619; 6167263; 6172288; 9865955; 1707161

# Macromolecular_Interacting_Partner_1_References:
10531329; 11023837; 11170392; 11498081

# Macromolecular_Interacting_Partner_2_ID:
7551

# Macromolecular_Interacting_Partner_2_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_2_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_2_Locus:
6p21.3

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_2_References:
11849318; 1644666; 2162791; 2583226

# Macromolecular_Interacting_Partner_3_ID:
7553

# Macromolecular_Interacting_Partner_3_Name:
Interleukin-1 beta precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
IL-1 beta; Catabolin

# Macromolecular_Interacting_Partner_3_Gene_Name:
IL1B

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Interleukin1 beta precursor
MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG
FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR
SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE
KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST
SQAENMPVFLGGTKGGQDITDFTMQFVSS

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
269

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
30748

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
4.45

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  cytokine activity
Function:  interleukin-1 receptor binding
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
Process:  inflammatory response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00340:IL1;
PF02394:IL1_propep

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
307043

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
IL1B_HUMAN (P01584)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
IL1B

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
IL1B

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:5992

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>810 bp
ATGGCAGAAGTACCTAAGCTCGCCAGTGAAATGATGGCTTATTACAGTGGCAATGAGGAT
GACTTGTTCTTTGAAGCTGATGGCCCTAAACAGATGAAGTGCTCCTTCCAGGACCTGGAC
CTCTGCCCTCTGGATGGCGGCATCCAGCTACGAATCTCCGACCACCACTACAGCAAGGGC
TTCAGGCAGGCCGCGTCAGTTGTTGTGGCCATGGACAAGCTGAGGAAGATGCTGGTTCCC
TGCCCACAGACCTTCCAGGAGAATGACCTGAGCACCTTCTTTCCCTTCATCTTTGAAGAA
GAACCTATCTTCTTCGACACATGGGATAACGAGGCTTATGTGCACGATGCACCTGTACGA
TCACTGAACTGCACGCTCCGGGACTCACAGCAAAAAAGCTTGGTGATGTCTGGTCCATAT
GAACTGAAAGCTCTCCACCTCCAGGGACAGGATATGGAGCAACAAGTGGTGTTCTCCATG
TCCTTTGTACAAGGAGAAGAAAGTAATGACAAAATACCTGTGGCCTTGGGCCTCAAGGAA
AAGAATCTGTACCTGTCCTGCGTGTTGAAAGATGATAAGCCCACTCTACAGCTGGAGAGT
GTAGATCCCAAAAATTACCCAAAGAAGAAGATGGAAAAGCGATTTGTCTTCAACAAGATA
GAAATCAATAACAAGCTGGAATTTGAGTCTGCCCAGTTCCCCAACTGGTACATCAGCACC
TCTCAAGCAGAAAACATGCCCGTCTTCCTGGGAGGGACCAAAGGCGGCCAGGATATAACT
GACTTCACCATGCAATTTGTGTCTTCCTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
K02770

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_3_Locus:
2q14

# Macromolecular_Interacting_Partner_3_SNPs:
rs1143634; rs16062; rs1071676; rs1143628; rs1799916; rs10176689; rs1143629; rs1143643; rs3917356; rs1143641; rs1143637; rs3136558; rs1143630; rs1143644; rs3917359; rs1143636; rs3917358; rs3917348; rs1143639; rs3136557; rs1143638; rs3917360; rs1143640; rs1143631; rs3917352; rs34159283; rs3087260; rs1143633; rs1143642; rs3917351; rs41294738; rs34701301; rs3917354; rs4144511; rs2464906; rs3730364; rs3087259; rs2853550; rs1143623; rs3917362; rs1143627; rs16944; rs1143624; rs1143625; rs3917365; rs6710598; rs1143626; rs3087258; rs3917364; rs3087261; rs3917345; rs15610; rs3917347; rs1133558; rs1133555; rs28730866; rs2464904; rs3917378; rs2853627; rs3917355; rs3917361; rs13401015; rs12991344; rs2853548; rs2853626; rs34661316; rs3020204; rs2853549; rs3917350; rs2952721; rs3917357; rs2853547; rs2708928; rs2853546; rs2464905; rs3917353; rs1143635; rs3917349; rs2708929; rs3917379; rs3917380; rs9636360; rs10183049; rs2853545; rs34888003; rs10560589; rs34613511; rs3917346; rs10560590; rs5021469; rs34156895; rs2708920; rs11395090; rs2708921; rs4986962; rs11297581; rs5833463; rs35599261; rs2708974; rs2853551; rs5833464; rs10169916; rs12621220; rs12623093; rs13013349; rs13032029; rs13424846; rs3087257; rs3917367; rs3917368; rs3917369; rs3917372; rs3917377; rs3917386; rs4848306; rs4849126; rs4849127; rs6721954; rs7556811; rs7596461; rs7596684

# Macromolecular_Interacting_Partner_3_General_References:
6083565; 2989698; 3490654; 2954882; 3493774; 2635664; 11991722; 3281727; 1919436; 1837236; 3259176; 2602367; 2585509; 9062193; 2372550; 2001363

# Macromolecular_Interacting_Partner_3_References:
1693530

# Macromolecular_Interacting_Partner_4_ID:
7429

# Macromolecular_Interacting_Partner_4_Name:
Amyloid beta A4 protein precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
APP; ABPP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; Protease nexin-II; PN-II; APPI; PreA4[Contains: Soluble APP-alpha; S-APP- alpha; Soluble APP-beta; S-APP-beta; C99; Beta-amyloid protein 42; Beta-APP42; Beta-amyloid protein 40; Beta-APP40; C83; P3(42; P3(40; Gamma-CTF(59; Gamma-secretase C-terminal fragment 59; Amyloid intracellular domain 59; AID(59; AICD-59; Gamma-CTF(57; Gamma-secretase C-terminal fragment 57; Amyloid intracellular domain 57; AID(57; AICD-57; Gamma-CTF(50; Gamma-secretase C-terminal fragment 50; Amyloid intracellular domain 50; AID(50; AICD-50; C31]

# Macromolecular_Interacting_Partner_4_Gene_Name:
APP

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Amyloid beta A4 protein precursor
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
770

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
86944

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
4.45

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  protease inhibitor activity
Function:  endopeptidase inhibitor activity
Function:  serine-type endopeptidase inhibitor activity
Function:  binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF02177:A4_EXTRA;
PF03494:Beta-APP;
PF00014:Kunitz_BPTI

# Macromolecular_Interacting_Partner_4_Signals:
1-17

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
700-723

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
28526

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
A4_HUMAN (P05067)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
APP

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
APP

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:620

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane; single-pass type I membrane protein. Note=Cell surface protein that rapidly becomes internalized via clathrin-coated pits. During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O- glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C- terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. Gamma-CTF(59) peptide is located to both the cytoplasm and nuclei of neurons. It can be translocated to the nucleus through association with Fe65. Beta- APP42 associates with FRPL1 at the cell surface and the complex is then rapidly internalized. APP sorts to the basolateral surface in epithelial cells. During neuronal differentiation, the Thr-743 phosphorylated form is located mainly in growth cones, moderately in neurites and sparingly in the cell body. Casein kinase phosphorylation can occur either at the cell surface or within a post-Golgi compartment

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>2088 bp
ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTA
CCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGA
CTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAA
ACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTG
CAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGG
GGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGT
GAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGG
ATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAG
AAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGA
GGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGAT
GCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGG
AGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAA
GAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAA
CCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACA
GAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTT
GACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAA
GAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAG
GCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTC
CAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAG
ACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAAC
TACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAG
AAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAGCATTTCGAGCATGTG
CGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGT
GTGATTTATGAGCGCATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCC
GAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAAAACTATTCAGATGAC
GTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCA
TCTTTGACCGAAACGAAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTG
GACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCAGCCAACACAGAAAAC
GAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGT
TCTGGGTTGACAAATATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTC
CGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTCTTTGCAGAAGATGTG
GGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTG
ATCGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTG
GTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGTCCAAGATGCAGCAGAAC
GGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAG

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
Y00264

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_4_Locus:
Not Available

# Macromolecular_Interacting_Partner_4_SNPs:
rs1059461; rs2830023; rs429410; rs2830044; rs2830029; rs2830094; rs455465; rs400603; rs2830104; rs2829969; rs2830084; rs2234988; rs2830019; rs2829979; rs2830002; rs2830057; rs762479; rs2830010; rs2830088; rs2830052; rs2829966; rs214482; rs216773; rs2251337; rs2246115; rs2829992; rs214488; rs214485; rs2830041; rs2830095; rs2830101; rs2256331; rs2830033; rs2830009; rs1876064; rs2830034; rs2830100; rs2830096; rs2830099; rs2830068; rs214484; rs376063; rs383700; rs2830102; rs2154482; rs380417; rs182525; rs2830000; rs768039; rs2830050; rs440666; rs2829972; rs2211773; rs768040; rs2830046; rs467021; rs2830021; rs2830012; rs2830066; rs375369; rs2000988; rs57126; rs2830038; rs2242683; rs367489; rs2248682; rs2830025; rs1876063; rs2829996; rs2830051; rs2830047; rs1701001; rs928902; rs2830097; rs2830054; rs1787439; rs1394841; rs2830048; rs1041420; rs2830089; rs2830006; rs2186302; rs216779; rs465235; rs1787435; rs2830076; rs2830026; rs2830031; rs2830015; rs454017; rs2830064; rs4817090; rs8129692; rs2829983; rs2830030; rs11910608; rs216763; rs2211771; rs436587; rs2830040; rs1701004; rs2830024; rs170066; rs8127122; rs8128764; rs2830005; rs2234989; rs2070657; rs2830072; rs432766; rs4518042; rs2040278; rs214486; rs2234990; rs2830049; rs2830060; rs216776; rs393364; rs2830077; rs2830067; rs2830027; rs2829988; rs731524; rs2829998; rs8130594; rs8128570; rs2830016; rs2829970; rs2070653; rs2830001; rs2830083; rs2830073; rs7278760; rs373521; rs2829984; rs2830037; rs2830003; rs2830053; rs2830045; rs2830065; rs2830004; rs1783026; rs2051176; rs7278838; rs2830092; rs1787438; rs2211772; rs2829976; rs216772; rs2830017; rs2829977; rs2830011; rs2829985; rs12482753; rs2830061; rs731523; rs128648; rs2829990; rs7282327; rs2830078; rs2830020; rs2829967; rs7276036; rs2830039; rs2830056; rs7282032; rs2830074; rs979184; rs2830058; rs11910324; rs2830082; rs2830079; rs2829981; rs2830036; rs2829989; rs2830093; rs216780; rs2830042; rs2829997; rs214480; rs216757; rs2830007; rs2830086; rs2830070; rs1782983; rs466609; rs1783016; rs2070655; rs2830081; rs454312; rs2829986; rs2830008; rs2830069; rs2829974; rs2830032; rs2830059; rs2830014; rs4817079; rs743532; rs2830062; rs368196; rs6516718; rs9305281; rs2829993; rs2000989; rs2830028; rs2070656; rs2040277; rs9982134; rs2829978; rs2829968; rs2830085; rs7279119; rs399330; rs2830075; rs2830043; rs7282689; rs2226332; rs2226330; rs2830035; rs2829980; rs2829982; rs2829987; rs9305282; rs2830022; rs2830013; rs3787644; rs10432774; rs2070652; rs2040276; rs2830090; rs3991; rs2830103; rs2026225; rs2014146; rs2830071; rs2830018; rs2829994; rs2830080; rs2830063; rs1787440; rs2829975; rs439826; rs7275602; rs2829973; rs12483003; rs17001492; rs11910285; rs11701219; rs7283143; rs11910599; rs8133264; rs11909451; rs2829991; rs17588612; rs7280727; rs6516711; rs2070654; rs6516727; rs8128100; rs9982732; rs11909661; rs3737416; rs2409160; rs4817077; rs12482613; rs7283136; rs3787638; rs6516713; rs1782978; rs429338; rs372515; rs1605087; rs458848; rs11911571; rs2830091; rs3827217; rs7278851; rs12482314; rs17001672; rs216762; rs2226350; rs2154481; rs2234983; rs1701003; rs3859683; rs2186301; rs17001660; rs9305271; rs17001455; rs2830087; rs6516715; rs9941877; rs7281226; rs3827166; rs1783020; rs7278223; rs9976060; rs461699; rs7281821; rs11702267; rs2829995; rs461315; rs9305268; rs425146; rs3787629; rs2234985; rs3787622; rs12626960; rs11911744; rs3787620; rs11701375; rs9305274; rs7279018; rs4817083; rs9981894; rs8131895; rs7276737; rs8128058; rs3787645; rs1701002; rs8132220; rs11910962; rs8128731; rs2409162; rs12482705; rs2226331; rs2830055; rs1783024; rs8131144; rs9754096; rs9983556; rs216775; rs3787641; rs2027700; rs12482813; rs216778; rs11087984; rs9305269; rs3787634; rs12482262; rs469420; rs11087985; rs2051174; rs216782; rs439196; rs456728; rs7281216; rs8129936; rs6516726; rs10482971; rs7283050; rs4380328; rs8132200; rs12626595; rs11910049; rs9981258; rs10222107; rs1783025; rs17001483; rs7280059; rs3737415; rs9305267; rs436025; rs12483305; rs743290; rs10154121; rs3787630; rs9982544; rs9980729; rs454557; rs4816273; rs12481729; rs3787650; rs10482970; rs11911318; rs8130724; rs1782980; rs6516717; rs3787637; rs9305272; rs7275672; rs413577; rs7282612; rs9976453; rs436011; rs4817078; rs7283265; rs8130440; rs12626674; rs1787441; rs7279377; rs1782984; rs12482910; rs9974796; rs9980420; rs17001583; rs2234982; rs17514385; rs9981695; rs17001670; rs462281; rs7283774; rs8132677; rs12626415; rs4817073; rs7282534; rs7276528; rs8126837; rs17001673; rs3787643; rs169963; rs9974885; rs214487; rs2051175; rs3787639; rs13050270; rs1621506; rs8128923; rs12482071; rs12626697; rs1967945; rs7280728; rs1701000; rs985798; rs13052965; rs11909273; rs12482330; rs7276186; rs8131642; rs9975699; rs882762; rs4817084; rs7277612; rs11087990; rs2243327; rs8127829; rs17001582; rs461639; rs13047183; rs928762; rs17001704; rs9636774; rs12482689; rs2226349; rs17001667; rs214490; rs170065; rs17001714; rs216781; rs13049230; rs3737413; rs11910060; rs7276205; rs418144; rs172592; rs4817072; rs2234991; rs7278738; rs9984764; rs1783019; rs7281709; rs1782976; rs9981915; rs17001698; rs372095; rs11702016; rs416527; rs417676; rs465984; rs7364107; rs9636777; rs17001473; rs9983524; rs9983845; rs9305280; rs8127963; rs410176; rs9977911; rs1625289; rs12627300; rs1876061; rs16997475; rs9977146; rs17001581; rs1009894; rs1788283; rs7276497; rs3787642; rs7281055; rs7279104; rs2040279; rs2829971; rs214495; rs11910723; rs7277117; rs8126680; rs7280839; rs11087983; rs10854297; rs2242690; rs455316; rs128647; rs12626594; rs467094; rs9305270; rs2051503; rs442540; rs12481757; rs17001661; rs216774; rs455921; rs13046704; rs8126846; rs216769; rs7283500; rs2027600; rs432811; rs10460695; rs12481905; rs2234984; rs1015007; rs9979927; rs9305266; rs8132329; rs10084571; rs7276754; rs457303; rs1782975; rs8128054; rs12626523; rs17803163; rs4817071; rs2234986; rs396969; rs1788285; rs12482573; rs11909265; rs3787635; rs3787625; rs370345; rs11701908; rs7278750; rs7278877; rs2154476; rs11909998; rs4175; rs13052904; rs1876062; rs8132601; rs17001470; rs374965; rs11910024; rs12626688; rs12482070; rs8132389; rs7280046; rs9982587; rs8133611; rs8184929; rs3787631; rs2089241; rs465853; rs17001683; rs12233316; rs17001662; rs1015006; rs8130827; rs216761; rs762135; rs9978555; rs458727; rs8127826; rs8130469; rs11701307; rs1782974; rs4816276; rs3827216; rs17001475; rs462278; rs12483698; rs7278512; rs464278; rs8127138; rs4817070; rs17725562; rs466448; rs8128378; rs364048; rs364051; rs2019263; rs363973; rs11911813; rs11549661; rs34725003; rs1800557; rs41276552; rs1059478; rs35871145; rs11549660; rs459543; rs736479; rs3200120; rs9808811; rs4817085; rs9980088; rs9808682; rs5843203; rs35528414; rs11295673; rs11324650; rs11431613; rs9982540; rs11354409; rs2409158; rs7282325; rs464262; rs11319953; rs35246546; rs34060570; rs455047; rs11371098; rs34345720; rs7281071; rs11332774; rs17001530; rs9982337; rs34129712; rs2067594; rs35457102; rs10600073; rs9979157; rs35254902; rs8131236; rs11910462; rs11315241; rs35065964; rs721720; rs7276957; rs35070948; rs11429344; rs11429337; rs41276550; rs3787636; rs9984159; rs9983396; rs35814504; rs11371103; rs9975360; rs36022345; rs34245275; rs11330553; rs35481640; rs2154480; rs3838072; rs6147459; rs11340783; rs35553157; rs5843211; rs216760; rs4816271; rs11310442; rs9974611; rs5843190; rs35314751; rs3084255; rs10686801; rs11438399; rs11346396; rs1782977; rs11295669; rs34555954; rs34453423; rs762480; rs184200; rs34986959; rs9980884; rs9979255; rs34552040; rs11378786; rs11440621; rs2409164; rs35288332; rs11396713; rs28378072; rs2154475; rs2242688; rs35063252; rs11292296; rs986464; rs11295668; rs11295670; rs13050592; rs5843210; rs7410071; rs3084286; rs11288363; rs35687461; rs10547972; rs11374741; rs34984056; rs35525004; rs1783018; rs33987222; rs34383066; rs35475483; rs11332781; rs16997468; rs35787828; rs7510303; rs9974801; rs17001462; rs2938855; rs36104734; rs6516720; rs467956; rs1146; rs34351670; rs34948904; rs35745552; rs35642920; rs35925658; rs7276845; rs1701007; rs35743774; rs10711917; rs35680514; rs35269152; rs5843188; rs34715782; rs4817089; rs35689070; rs35702065; rs35006734; rs35247824; rs35459219; rs34672776; rs10710344; rs9982306; rs9636778; rs11087986; rs7276210; rs10674109; rs35296496; rs4817080; rs35503500; rs3787649; rs35844317; rs13050406; rs34224410; rs216767; rs3084231; rs9984251; rs9982314; rs11306462; rs1475833; rs3787632; rs11405152; rs4816272; rs11429340; rs34311196; rs35160383; rs34463129; rs28493591; rs34008965; rs34092026; rs34223469; rs34052896; rs34393238; rs2409154; rs11429343; rs33950559; rs34656525; rs34365621; rs10682139; rs7277169; rs5843194; rs9983517; rs34693350; rs34491747; rs11087982; rs11417250; rs34139677; rs36045785; rs34516852; rs34466987; rs35377832; rs2040235; rs34532223; rs10718700; rs34131328; rs13052360; rs35811423; rs3084283; rs34247316; rs1783015; rs28626763; rs9941901; rs9653649; rs10572923; rs10579923; rs36115961; rs35169092; rs11440718; rs35726412; rs28572218; rs34725553; rs1700991; rs34911959; rs9974096; rs33925464; rs34082104; rs13049214; rs34362979; rs10718697; rs440736; rs35686175; rs13047500; rs17001547; rs11315242; rs11288428; rs34736654; rs34754144; rs2242687; rs34602809; rs11332971; rs3838075; rs13050715; rs11304797; rs453180; rs5843184; rs11319717; rs34791307; rs425860; rs35225694; rs11295667; rs389250; rs35031616; rs3838073; rs10652739; rs10567031; rs765932; rs34829549; rs28717708; rs416524; rs11295674; rs35443770; rs10617724; rs34021818; rs7275712; rs11324651; rs34239681; rs34257610; rs3084230; rs2409167; rs2409159; rs36048306; rs7278584; rs35103087; rs11371099; rs35389684; rs9979333; rs7283815; rs34456443; rs382358; rs34923919; rs7277555; rs9978790; rs33970128; rs36003052; rs36045123; rs11332782; rs1700995; rs11283222; rs33964326; rs11292295; rs2135193; rs13048917; rs11356038; rs35205640; rs11314084; rs9975669; rs5843200; rs17001686; rs11298424; rs2657503; rs5843204; rs13049726; rs2017163; rs10646250; rs35126738; rs11295671; rs11330953; rs2012155; rs5843193; rs4816270; rs7281027; rs10686828; rs35742342; rs35374535; rs35795843; rs10713554; rs34670795; rs10529214; rs10716601; rs9305278; rs13052264; rs36008546; rs13047600; rs34932091; rs3787653; rs35526392; rs35830685; rs9982027; rs34408244; rs2089242; rs35168701; rs11331624; rs4389394; rs11429341; rs4990026; rs34082339; rs1788284; rs10697274; rs35806741; rs7280619; rs34996710; rs1782979; rs5843180; rs11371100; rs11301172; rs6516719; rs17588151; rs216766; rs7277057; rs183361; rs10084562; rs5843189; rs35080722; rs411207; rs1623254; rs5843207; rs11329266; rs34594285; rs5843212; rs9976487; rs2242689; rs35716741; rs28402785; rs34986093; rs1023376; rs2409155; rs35227250; rs4817076; rs8130747; rs34069718; rs34148707; rs4817088; rs28403442; rs34561763; rs35920911; rs2211766; rs34313237; rs11319018; rs9976477; rs1783022; rs182470; rs34063743; rs465074; rs35083366; rs10718479; rs2243328; rs34306486; rs11353675; rs34689100; rs10647133; rs10649843; rs34458306; rs7277419; rs3787647; rs35829496; rs10689684; rs216765; rs1700997; rs34343142; rs214493; rs34687470; rs7410142; rs8132591; rs2016934; rs3834673; rs10706416; rs8127323; rs5843197; rs13049648; rs36001594; rs11297949; rs10638132; rs8126691; rs35712724; rs2242684; rs9975805; rs8130138; rs9980574; rs35051891; rs214481; rs11458855; rs9980841; rs35745852; rs10554042; rs11332777; rs35349551; rs3787640; rs13051675; rs9978084; rs12482494; rs5843185; rs34030307; rs35501507; rs11298423; rs3737414; rs11407443; rs387635; rs11702040; rs9983719; rs11332778; rs34762279; rs7281775; rs35655516; rs28488972; rs34801112; rs9980178; rs35541415; rs13048779; rs35238316; rs4817075; rs7279544; rs35186906; rs13048354; rs35186839; rs10670054; rs10718699; rs10718698; rs5843201; rs34322089; rs11363242; rs214489; rs2242686; rs7278994; rs10716140; rs9976813; rs2000719; rs7283060; rs11271442; rs11295666; rs34305411; rs11332783; rs28375617; rs12483107; rs11295672; rs11911151; rs6516725; rs34772328; rs35250381; rs7277559; rs11319019; rs7281901; rs28735376; rs11334027; rs34744316; rs5843186; rs34054230; rs17001747; rs5014056; rs2242691; rs9978977; rs11452565; rs35349830; rs11371096; rs1701009; rs11443260; rs7282037; rs216771; rs33976509; rs6516714; rs34394589; rs34101073; rs34259190; rs11339125; rs1981326; rs35476811; rs7281116; rs7283144; rs1023374; rs11306303; rs11371101; rs11391760; rs170064; rs35685721; rs11319719; rs4817087; rs11455808; rs11275386; rs9305277; rs11288362; rs28579148; rs10581246; rs8132219; rs2409166; rs11332776; rs216777; rs34188773; rs34836373; rs35999452; rs34606412; rs11332775; rs11301860; rs35029493; rs5843196; rs1023375; rs409215; rs12626555; rs7281979; rs11368825; rs35145588; rs190054; rs10581495; rs35388438; rs34030961; rs11318092; rs2409156; rs36110521; rs2234992; rs214494; rs41435646; rs34262386; rs10556702; rs2154474; rs34917154; rs35310764; rs35839930; rs34978520; rs8127843; rs34969698; rs9984633; rs11461938; rs1700994; rs2000454; rs1787436; rs400154; rs9976425; rs4996605; rs7276465; rs3084256; rs9981606; rs34011583; rs12626726; rs9978090; rs2096488; rs12627637; rs35206910; rs10638133; rs34344776; rs41276548; rs9981102; rs35571453; rs34087368; rs11461939; rs10718480; rs9636776; rs11360144; rs5843213; rs35565019; rs216764; rs35472845; rs35614626; rs3084288; rs35205777; rs10628823; rs11295675; rs404164; rs10649167; rs9647117; rs11304862; rs28501333; rs41276546; rs13048234; rs10656191; rs5843208; rs11450751; rs35215437; rs13050302; rs5843179; rs11354106; rs35523723; rs35221471; rs35407047; rs8133711; rs36052312; rs35702720; rs11272683; rs1701010; rs28529026; rs11378700; rs10657981; rs11330850; rs34013951; rs10084563; rs35210038; rs2298323; rs5843182; rs2073460; rs6516709; rs11429342; rs11370154; rs462225; rs1783021; rs10549163; rs8133736; rs34988024; rs11429339; rs28593324; rs35834780; rs28634830; rs11353750; rs7278761; rs35504500; rs5843181; rs35137105; rs35118554; rs35532414; rs10670053; rs11374950; rs2409165; rs2243326; rs5843202; rs35920199; rs34466165; rs5843206; rs1145; rs36081542; rs11332784; rs9983802; rs2657505; rs4405833; rs11394554; rs34958080; rs10547971; rs28684415; rs13049462; rs13048758; rs11701915; rs11379637; rs35064916; rs35971897; rs35186157; rs36001790; rs34817911; rs35761427; rs13050293; rs4493343; rs216768; rs11350204; rs34038714; rs7279543; rs11315240; rs13050256; rs5843195; rs9981764; rs10222113; rs9979965; rs2211770; rs9983222; rs9305273; rs34481840; rs34285555; rs34770453; rs5843191; rs7281234; rs35301905; rs34879235; rs10532653; rs191962; rs11702680; rs35235013; rs216758; rs11332779; rs11909477; rs9978546; rs7276731; rs35781950; rs34965345; rs35254481; rs5843209; rs177294; rs2051504; rs9984751; rs35436719; rs9978820; rs4817086; rs17001536; rs11371102; rs35647703; rs9636779; rs36111129; rs34371241; rs34238270; rs5843187; rs11702037; rs214492; rs9977800; rs10549715; rs11371097; rs34722047; rs10600074; rs11315998; rs5843198; rs1612963; rs35906098; rs35435851; rs1547353; rs34300594; rs34216444; rs4817074; rs33997553; rs11443261; rs10707239; rs28455650; rs1700993; rs4444618; rs5843192; rs4996606; rs34000188; rs9636571; rs35946042; rs34144393; rs7276426; rs1700999; rs34654197; rs36096915; rs11412792; rs11332780; rs5843199; rs11702083; rs11378041; rs216759; rs11288364; rs35971627; rs12626857; rs5843214; rs9984154; rs1783017; rs35567091; rs9798665; rs380662; rs33940199; rs12482634; rs36089254; rs11909527; rs34472522; rs35652976; rs11373472; rs7280004; rs35579863; rs2242692; rs9982327; rs216770; rs35464089; rs9984059; rs2234987; rs7282148; rs1605086; rs933125; rs10718701; rs11909803; rs11295676; rs9982838; rs35378112; rs28635874; rs8127388; rs10659691; rs17001668; rs12329885; rs34458585; rs5843183; rs36008087; rs35339887; rs5843205; rs4261780; rs11319718; rs28615305; rs11429338; rs9975859; rs9978069; rs9636775; rs12482672; rs9978471; rs35908500; rs9647116; rs9798663; rs34054020; rs7280009; rs7282911; rs13047508; rs28504365; rs2409153; rs13046930; rs11426429; rs28412041; rs9979322; rs9976873; rs5843178; rs458821; rs10556992; rs13047883; rs35200666; rs11910062; rs34800671; rs928903; rs10549149; rs2242685; rs7277433; rs2938854; rs13049867; rs12483639; rs128646; rs10716141; rs466433; rs34678001; rs9976660; rs1787442; rs11326732; rs443977; rs214483; rs11299404; rs9976877; rs1700992; rs1235885; rs12482978; rs17001452; rs17001453; rs1788286; rs1981369; rs2012513; rs2040274; rs2156079; rs2234981; rs2242682; rs34471515; rs363935; rs363999; rs364106; rs364114; rs368833; rs428971; rs438031; rs438314; rs442901; rs446884; rs452987; rs7276470

# Macromolecular_Interacting_Partner_4_General_References:
2881207; 2893289; 2783775; 2110105; 1587857; 9108164; 12859342; 3140222; 2538123; 3597385; 12665801; 2569763; 3035574; 2893290; 2893291; 2893379; 8576160; 8476439; 2675837; 8109908; 8229004; 3312495; 8248178; 3810169; 2949367; 7737970; 9168929; 11775062; 2506449; 1969731; 8344894; 8446172; 7913895; 8158260; 8886002; 8626687; 8887653; 8855266; 9357988; 9338779; 9843960; 10413512; 10535332; 9890987; 10383380; 10461923; 10816430; 10681545; 11689470; 11278849; 11274207; 11438549; 11544248; 11238726; 11943163; 11724784; 11784781; 12032279; 8131745; 8999878; 9585534; 10319819; 10341243; 10806211; 10742146; 11517218; 11146006; 11851430; 11877420; 10201399; 2125487; 9300481; 1718421; 7516706; 7588758; 8973180; 9693002; 10940222; 10940221; 10821838; 2900137; 12142279; 1363811; 2111584; 1671712; 1908231; 1678058; 1944558; 1925564; 1415269; 1303239; 1302033; 1307241; 1303275; 8267572; 8154870; 8290042; 8577393; 9328472; 9754958; 10097173; 10631141; 10665499; 10867787; 11063718; 11409420; 11528419

# Macromolecular_Interacting_Partner_4_References:
7602619; 8468348; 8562317

# Macromolecular_Interacting_Partner_5_ID:
7589

# Macromolecular_Interacting_Partner_5_Name:
Heparin-binding growth factor 2 precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
HBGF-2; Basic fibroblast growth factor; BFGF; Prostatropin

# Macromolecular_Interacting_Partner_5_Gene_Name:
FGF2

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Heparinbinding growth factor 2 precursor
MAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHI
KLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKY
TSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
155

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
17254

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
10.01

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00167:FGF

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
31362

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
FGF2_HUMAN (P09038)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
FGF2

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
FGF2

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:3676

# Macromolecular_Interacting_Partner_5_PDB_ID:
1IIL

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>178 bp
ATGGCAGCCGGGAGCATCACCACGCTGCCCGCCTTGCCCGAGGATGGCGGCAGCGGCGCC
TTCCCGCCCGGCCACTTCAAGGACCCCAAGCGGCTGTACTGCAAAAACGGGGGCTTCTTC
CTGCGCATCCACCCCGACGGCCGAGTTGACGGGGTCCGGGAGAAGAGCGACCCTCACA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
X04431

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_5_Locus:
4q26-q27

# Macromolecular_Interacting_Partner_5_SNPs:
rs1449683; rs308420; rs308440; rs308435; rs2034461; rs3804150; rs308417; rs308437; rs1563705; rs3804155; rs1563707; rs4495052; rs308401; rs2926172; rs308380; rs7674648; rs308441; rs1960669; rs7694627; rs11938826; rs308418; rs3789138; rs308442; rs308413; rs308434; rs308439; rs1476214; rs308438; rs6534365; rs10452155; rs308382; rs308379; rs308404; rs308443; rs6534363; rs308411; rs308388; rs7700205; rs308402; rs366192; rs12644427; rs308444; rs308427; rs10000779; rs308419; rs9307514; rs308403; rs2125446; rs308432; rs2922979; rs3099832; rs17006247; rs167428; rs35455745; rs4833845; rs2922980; rs1547498; rs308390; rs12503378; rs308409; rs6817113; rs308384; rs308423; rs17006219; rs6534366; rs11938657; rs12640514; rs9307513; rs308383; rs2922981; rs9307512; rs308415; rs17407577; rs4441767; rs6819187; rs308422; rs17472986; rs308405; rs1992980; rs17408757; rs308421; rs308407; rs17408557; rs12506776; rs308428; rs6534364; rs11944461; rs17473132; rs2922982; rs9990554; rs41505450; rs17006214; rs11725156; rs10452197; rs6830581; rs7692645; rs13111465; rs17006255; rs41501654; rs6813335; rs308412; rs308424; rs10012814; rs172621; rs41425047; rs17006267; rs6534367; rs17006244; rs17474021; rs17006215; rs1476218; rs12642291; rs4554090; rs308431; rs12506710; rs41453044; rs17408275; rs184278; rs41333248; rs17473335; rs4591621; rs41346246; rs10155176; rs308373; rs11934448; rs2926171; rs41537948; rs10518406; rs7435114; rs308408; rs308378; rs13109930; rs41436350; rs10011927; rs308389; rs17006269; rs374880; rs308426; rs41451247; rs308416; rs41354048; rs10518407; rs10028204; rs308430; rs1530750; rs6816891; rs10470916; rs308374; rs12651208; rs9996546; rs9997146; rs308381; rs308386; rs416124; rs17006188; rs41364948; rs33948716; rs308433; rs17407626; rs308425; rs10035081; rs308395; rs308393; rs308398; rs308394; rs41456044; rs41440644; rs308399; rs308400; rs12509482; rs308410; rs28449370; rs34403033; rs4574429; rs13435300; rs308385; rs10011810; rs10032674; rs35597051; rs28666404; rs34928342; rs28439566; rs33941144; rs28700233; rs308376; rs11310783; rs9760326; rs35486394; rs28524008; rs421184; rs308445; rs6831512; rs177814; rs6818394; rs34921138; rs10428271; rs13119363; rs5861583; rs308372; rs5861582; rs308436; rs4356923; rs35796579; rs7436556; rs36120812; rs7693141; rs33921944; rs13118682; rs3034589; rs367344; rs34866665; rs10049563; rs34614005; rs36121815; rs4561939; rs35967448; rs1971231; rs9760327; rs34982248; rs308446; rs4305529; rs34959980; rs35214963; rs12650293; rs7693557; rs6824785; rs34368993; rs11737391; rs968346; rs11731431; rs308377; rs36028417; rs35282289; rs367331; rs10034983; rs5861581; rs4146526; rs9997559; rs35398841; rs11356589; rs3804144; rs308406; rs1984971; rs373125; rs34274268; rs17006259; rs12509901; rs28687896; rs35084716; rs34795683; rs34667057; rs3034598; rs453734; rs11942841; rs308429; rs375329; rs4254785; rs9999882; rs28464097; rs33986146; rs34391757; rs33957464; rs308387; rs13118875; rs28853921; rs3034594; rs36022743; rs35287534; rs34552935; rs12504045; rs35828733; rs34233719; rs28544074; rs34059519; rs6830889; rs728694; rs11937491; rs35383312; rs308414; rs41372044; rs35449274; rs411027; rs35020389; rs34590557; rs34519178; rs17006187; rs34728714; rs11372121; rs34421619; rs35644150; rs12650248; rs34406293; rs34814129; rs7660449; rs431151; rs10023647; rs12646810; rs34396179; rs28434503; rs35168640; rs308375; rs2926173; rs10434039; rs34541038; rs11938630; rs11385300; rs35406805; rs28529128; rs12510476; rs416947; rs7670829; rs1563704; rs3840101; rs3804151; rs35422508; rs308397; rs35363957; rs6829351; rs308396; rs6830094; rs6828763; rs1048201; rs11723769; rs11733450; rs11737764; rs11940156; rs12507250; rs13125068; rs13146863; rs1467995; rs1476215; rs1476216; rs1476217; rs1966277; rs1982569; rs1982570; rs2168915; rs2893026; rs308392; rs308447; rs3747676; rs3804156; rs3804158; rs3804159; rs3827582; rs6854081; rs7683093

# Macromolecular_Interacting_Partner_5_General_References:
3472745; 3780670; 3579930; 2435575; 2538817; 3732516; 3964259; 2435284; 1885605; 1769963; 1707542; 1849658; 1702556; 7691311; 11390973; 8885834

# Macromolecular_Interacting_Partner_5_References:
2468667; 8892973; 9780213

# Macromolecular_Interacting_Partner_6_ID:
7113

# Macromolecular_Interacting_Partner_6_Name:
Cytochrome c

# Macromolecular_Interacting_Partner_6_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_6_Gene_Name:
CYCS

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Cytochrome c
MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSYTAANKNKGIIW
GEDTLMEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNE

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
105

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
11749

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
10.16

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  binding
Function:  tetrapyrrole binding
Function:  heme binding
Function:  transporter activity
Function:  electron transporter activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Energy production and conversion 

# Macromolecular_Interacting_Partner_6_Specific_Function:
Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00034:Cytochrom_C

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
181242

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
CYC_HUMAN (P99999)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
CYCS

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
CYCS

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:19986

# Macromolecular_Interacting_Partner_6_PDB_ID:
1J3S

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>318 bp
ATGGGTGATGTTGAGAAAGGCAAGAAGATTTTTATTATGAAGTGTTCCCAGTGCCACACC
GTTGAAAAGGGAGGCAAGCACAAGACTGGGCCAAATCTCCATGGTCTCTTTGGGCGGAAG
ACAGGTCAGGCCCCTGGATACTCTTACACAGCCGCCAATAAGAACAAAGGCATCATCTGG
GGAGAGGATACACTGATGGAGTATTTGGAGAATCCCAAGAAGTACATCCCTGGAACAAAA
ATGATCTTTGTCGGCATTAAGAAGAAGGAAGAAAGGGCAGACTTAATAGCTTATCTCAAA
AAAGCTACTAATGAGTAA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
M22877

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_6_Locus:
7p15.2

# Macromolecular_Interacting_Partner_6_SNPs:
rs11769363; rs7810784; rs1861525; rs12700584; rs10215217; rs4719799; rs12700583; rs12700582; rs3846998; rs2107123; rs11548785; rs11548815; rs11548798; rs11548802; rs11548799; rs11548820; rs11548772; rs11548783; rs11548796; rs11548816; rs11548795; rs3211452; rs11548791; rs11548818; rs11548805; rs3211451; rs11548807; rs11548778; rs17851278; rs11548812; rs11548776; rs11548797; rs11548779; rs11548806; rs11548774; rs11548777; rs11427893; rs1137513; rs3173604; rs11548775; rs1060389; rs1137505; rs1137510; rs11548804; rs1801082; rs1060388; rs1137506; rs11548773; rs41275976; rs1137512; rs1137508; rs13310377; rs13310456; rs34522469; rs35325343; rs1137507; rs11548787; rs1137511; rs10230102; rs11548792; rs28376346; rs1137509; rs36061386; rs6967260; rs3040291; rs16873757; rs5882962; rs34102874; rs34500218; rs10238032; rs17150957; rs10278815; rs10279024; rs10951046; rs11489282; rs12700580; rs2107121; rs2107122; rs2391087; rs2717885; rs2717886

# Macromolecular_Interacting_Partner_6_General_References:
2849112; 12853948; 9515723

# Macromolecular_Interacting_Partner_6_References:
12686155; 7520259; 7556607; 7744026

# Macromolecular_Interacting_Partner_7_ID:
7699

# Macromolecular_Interacting_Partner_7_Name:
Myosin-binding protein H

# Macromolecular_Interacting_Partner_7_Synonyms:
MyBP-H; H-protein

# Macromolecular_Interacting_Partner_7_Gene_Name:
MYBPH

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Myosinbinding protein 
HMMEKNTSEGPACSPEETASESAKVPTAEPPGEVAVSESTREEQVPKPQAPAPQAPTAST
ATKPAPPSEDVPSAPLLLTLDDVSSSSVTVSWEPPERLGRLGLQGYVLELCREGASEWVP
VSARPMMVTQQTVRNLALGDKFLLRVSAVSSAGAGPPAMLDQPIHIRENIEAPKIRVPRH
LRQTYIRQVGETVNLQIPFQGKPKPQATWTHNGHALDSQRVSMRTGDQDSILFIRSAQRS
DSGRYELTVRVEDLEAKAVIDILVIEKPGPPSSIRLLDVWGCNAALQWTPPQDTGNTELL
GYMVQKADKKTGQWFTVLERYHPTTCTISDLIIGNSYSFRVFSENLCGLSTSATVTKELA
HIQKADIAAKPKGFIERDFSEAPSFTQPLADHTSTPGYSTQLFCSVRASPKPKIIWMKNK
MEIQGNPKYRALSEQGVCTLEIRKPSPFDSGVYTCKAINVLGEASVDCRLEVKASAAH

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
477

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
52051

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.71

# Macromolecular_Interacting_Partner_7_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Binds to myosin; probably involved in interaction with thick myofilaments in the A-band

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00041:fn3;
PF07679:I-set

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
292337

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
MYBPH_HUMAN (Q13203)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
MYBPH

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
MYBPH

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:7552

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1431 bp
ATGATGGAAAAAAACACCTCCGAGGGCCCTGCCTGCAGTCCAGAGGAGACCGCATCTGAA
TCTGCCAAGGTGCCCACAGCAGAGCCTCCCGGAGAAGTGGCAGTATCAGAGTCCACCAGA
GAAGAGCAGGTGCCCAAGCCGCACGGCCCTGCCCCACAGGCCCCTACAGCCTCCACAGCC
ACTAAGCCTGCACCCCCAAGTGAAGATGTCCCCAGTGCCCCACTGCTGCTGACCCTGGAT
GATGTGAGCAGCAGCTCTGTGACTGTGAGCTGGGAGCCCCCAGAGAGGCTGGGGAGGCTG
GGCCTCCAGGGCTATGTGCTGGAGCTCTGCAGAGAGGGAGCCTCGGAGTGGGTGCCTGTG
AGTGCCCGGCCCATGATGGTGACCCAGCAGACTGTGCGGAACCTGGCTCTGGGAGACAAG
TTCCTCCTGCGCGTGTCTGCAGTGAGTTCTGCAGGGGCTGGCCCGCCGGCCATGCTGGAC
CAGCCCATCCACATCCGAGAGAACATTGAGGCCCCCAAGATCCGTGTCCCCCGCCACCTC
CGTCAGACCTACATCCGCCAGGTGGGAGAGACGGTCAACCTGCAAATCCCCTTCCAGGGG
AAGCCTAAGCCTCAGGCCACATGGACCCACAACGGCCATGCCCTGGACAGCCAGCGGGTG
AGCATGCGCACCGGGGACCAGGACTCCATCCTCTTCATTCGCTCGGCCCAGCGCTCCGAC
TCTGGCCGCTACGAGCTCACTGTGCGCGTGGAAGACCTGGAGGCCAAGGCAGTCATTGAC
ATCCTGGTGATTGAGAAACCTGGACCCCCCAGCAGCATCAGGCTCCTGGACGTCTGGGGC
TGCAATGCTGCTCTTCAGTGGACGCCACCCCAGGACACAGGCAACACAGAGCTCCTGGGC
TACATGGTGCAGAAGGCAGACAAAAAGACAGGGCAATGGTTCACAGTGCTGGAGCGCTAC
CACCCAACCACCTGCACCATCTCTGACCTCATCATCGGCAACTCGTACTCCTTCCGGGTC
TTCTCAGAAAACCTGTGTGGACTCAGCACCTCGGCCACCGTCACCAAGGAGCTCGCCCAC
ATCCAGAAGGCAGATATTGCTGCCAAACCTAAAGGGTTTATTGAGCGAGACTTCTCAGAA
GCCCCCTCATTCACCCAGCCCCTGGCTGACCACACCTCCACCCCTGGCTACAGCACCCAG
TTGTTCTGCAGTGTCGAGCTTCACCAAGCCAAGATCATCTGGATGAAAAACAAGATGGAG
ATCCAGGGCAACCCCAAATACCGCGCCCTCTCTGAGCAAGGCGTCTGCACCCTAGAGATC
CGGAAACCCAGCCCCTTTGATTCTGGGGTCTACACCTGCAAGGCCATAAATGTGCTGGGG
GAGGCATCTGTGGACTGCCGGCTGGAGGTCAAAGCCTCAGCCGCACACTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
L05606

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_7_Locus:
1q32.1

# Macromolecular_Interacting_Partner_7_SNPs:
rs2642531; rs3737875; rs12145010; rs2788527; rs2250509; rs2788529; rs3737873; rs3737872; rs3766548; rs3766551; rs3766547; rs2791718; rs3766550; rs3737874; rs7545750; rs762625; rs883125; rs12139072; rs903359; rs2364572; rs12724763; rs17465574; rs2071013; rs12743504; rs7538338; rs2642533; rs2642532; rs2791721; rs34702760; rs2788532; rs4950879; rs12087754; rs12070378; rs17854307; rs35823777; rs34556384; rs2788528; rs2788530; rs12737716; rs12097720; rs3766549; rs2791719; rs2855403; rs33945931; rs12239297; rs2855402; rs2788531; rs2791720; rs2814499; rs12028355; rs35635529; rs2364573; rs3753470; rs12748526; rs3753469; rs1049406; rs1049451; rs1049452; rs10920576; rs10920577; rs10920578; rs11576067; rs11579990; rs11587584; rs11800284; rs11809836; rs12026765; rs12063956; rs12128727; rs12135560; rs12136486; rs12141494; rs12403904; rs12408583; rs12409713; rs12410110; rs12410262; rs12726499; rs12744240; rs1538372; rs1587053; rs1587054; rs16851017; rs16851020; rs16851029; rs16851030; rs16851032; rs17465037; rs17530497; rs1890871; rs2071579; rs2071580; rs2275351; rs2275352; rs2275353; rs2297838; rs2297839; rs2297840; rs2297945; rs2297946; rs35405821; rs3753472; rs3753473; rs3766552; rs3766553; rs3766554; rs3766555; rs3766556; rs3928869; rs4950926; rs4950927; rs7542294; rs7551263; rs880633; rs884209; rs903357; rs903358; rs903364; rs946259; rs946260

# Macromolecular_Interacting_Partner_7_General_References:
8486381

# Macromolecular_Interacting_Partner_7_References:
10473591; 10757974; 15355973; 1898363

# Macromolecular_Interacting_Partner_8_ID:
7932

# Macromolecular_Interacting_Partner_8_Name:
Pro-epidermal growth factor precursor

# Macromolecular_Interacting_Partner_8_Synonyms:
EGF[Contains: Epidermal growth factor; Urogastrone]

# Macromolecular_Interacting_Partner_8_Gene_Name:
EGF

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Proepidermal growth factor precursor
MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRID
TEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSG
MAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAG
SLYRADLDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHI
SKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHP
LAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNEC
AFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL
CFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASG
PQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERAN
MDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQP
RGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCD
AKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVR
LQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC
LALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGC
SMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCS
EGYQGDGIHCLDIDECQLGVHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHL
REDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWW
ELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRS
RRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGM
GTEQGCWIPVSSDKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPP
HQMELTQ

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
1207

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
133947

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
5.74

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00008:EGF;
PF07645:EGF_CA;
PF00058:Ldl_recept_b

# Macromolecular_Interacting_Partner_8_Signals:
1-22

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
1033-1053

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
31121

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
EGF_HUMAN (P01133)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
EGF

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
EGF

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:3229

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>3624 bp
ATGCTGCTCACTCTTATCATTCTGTTGCCAGTAGTTTCAAAATTTAGTTTTGTTAGTCTC
TCAGCACCGCAGCACTGGAGCTGTCCTGAAGGTACTCTCGCAGGAAATGGGAATTCTACT
TGTGTGGGTCCTGCACCCTTCTTAATTTTCTCCCATGGAAATAGTATCTTTAGGATTGAC
ACAGAAGGAACCAATTATGAGCAATTGGTGGTGGATGCTGGTGTCTCAGTGATCATGGAT
TTTCATTATAATGAGAAAAGAATCTATTGGGTGGATTTAGAAAGACAACTTTTGCAAAGA
GTTTTTCTGAATGGGTCAAGGCAAGAGAGAGTATGTAATATAGAGAAAAATGTTTCTGGA
ATGGCAATAAATTGGATAAATGAAGAAGTTATTTGGTCAAATCAACAGGAAGGAATCATT
ACAGTAACAGATATGAAAGGAAATAATTCCCACATTCTTTTAAGTGCTTTAAAATATCCT
GCAAATGTAGCAGTTGATCCAGTAGAAAGGTTTATATTTTGGTCTTCAGAGGTGGCTGGA
AGCCTTTATAGAGCAGATCTCGATGGTGTGGGAGTGAAGGCTCTGTTGGAGACATCAGAG
AAAATAACAGCTGTGTCATTGGATGTGCTTGATAAGCGGCTGTTTTGGATTCAGTACAAC
AGAGAAGGAAGCAATTCTCTTATTTGCTCCTGTGATTATGATGGAGGTTCTGTCCACATT
AGTAAACATCCAACACAGCATAATTTGTTTGCAATGTCCCTTTTTGGTGACCGTATCTTC
TATTCAACATGGAAAATGAAGACAATTTGGATAGCCAACAAACACACTGGAAAGGACATG
GTTAGAATTAACCTCCATTCATCATTTGTACCACTTGGTGAACTGAAAGTAGTGCATCCA
CTTGCACAACCCAAGGCAGAAGATGACACTTGGGAGCCTGAGCAGAAACTTTGCAAATTG
AGGAAAGGAAACTGCAGCAGCACTGTGTGTGGGCAAGACCTCCAGTCACACTTGTGCATG
TGTGCAGAGGGATACGCCCTAAGTCGAGACCGGAAGTACTGTGAAGATGTTAATGAATGT
GCTTTTTGGAATCATGGCTGTACTCTTGGGTGTAAAAACACCCCTGGATCCTATTACTGC
ACGTGCCCTGTAGGATTTGTTCTGCTTCCTGATGGGAAACGATGTCATCAACTTGTTTCC
TGTCCACGCAATGTGTCTGAATGCAGCCATGACTGTGTTCTGACATCAGAAGGTCCCTTA
TGTTTCTGTCCTGAAGGCTCAGTGCTTGAGAGAGATGGGAAAACATGTAGCGGTTGTTCC
TCACCCGATAATGGTGGATGTAGCCAGCTCTGCGTTCCTCTTAGCCCAGTATCCTGGGAA
TGTGATTGCTTTCCTGGGTATGACCTACAACTGGATGAAAAAAGCTGTGCAGCTTCAGGA
CCACAACCATTTTTGCTGTTTGCCAATTCTCAAGATATTCGACACATGCATTTTGATGGA
ACAGACTATGGAACTCTGCTCAGCCAGCAGATGGGAATGGTTTATGCCCTAGATCATGAC
CCTGTGGAAAATAAGATATACTTTGCCCATACAGCCCTGAAGTGGATAGAGAGAGCTAAT
ATGGATGGTTCCCAGCGAGAAAGGCTTATTGAGGAAGGAGTAGATGTGCCAGAAGGTCTT
GCTGTGGACTGGATTGGCCGTAGATTCTATTGGACAGACAGAGGGAAATCTCTGATTGGA
AGGAGTGATTTAAATGGGAAACGTTCCAAAATAATCACTAAGGAGAACATCTCTCAACCA
CGAGGAATTGCTGTTCATCCAATGGCCAAGAGATTATTCTGGACTGATACAGGGATTAAT
CCACGAATTGAAAGTTCTTCCCTCCAAGGCCTTGGCCGTCTGGTTATAGCCAGCTCTGAT
CTAATCTGGCCCAGTGGAATAACGATTGACTTCTTAACTGACAAGTTGTACTGGTGCGAT
GCCAAGCAGTCTGTGATTGAAATGGCCAATCTGGATGGTTCAAAACGCCGAAGACTTACC
CAGAATGATGTAGGTCACCCATTTGCTGTAGCAGTGTTTGAGGATTATGTGTGGTTCTCA
GATTGGGCTATGCCATCAGTAATAAGAGTAAACAAGAGGACTGGCAAAGATAGAGTACGT
CTCCAAGGCAGCATGCTGAAGCCCTCATCACTGGTTGTGGTTCATCCATTGGCAAAACCA
GGAGCAGATCCCTGCTTATATCAAAACGGAGGCTGTGAACATATTTGCAAAAAGAGGCTT
GGAACTGCTTGGTGTTCGTGTCGTGAAGGTTTTATGAAAGCCTCAGATGGGAAAACGTGT
CTGGCTCTGGATGGTCATCAGCTGTTGGCAGGTGGTGAAGTTGATCTAAAGAACCAAGTA
ACACCATTGGACATCTTGTCCAAGACTAGAGTGTCAGAAGATAACATTACAGAATCTCAA
CACATGCTAGTGGCTGAAATCATGGTGTCAGATCAAGATGACTGTGCTCCTGTGGGATGC
AGCATGTATGCTCGGTGTATTTCAGAGGGAGAGGATGCCACATGTCAGTGTTTGAAAGGA
TTTGCTGGGGATGGAAAACTATGTTCTGATATAGATGAATGTGAGATGGGTGTCCCAGTG
TGCCCCCCTGCCTCCTCCAAGTGCATCAACACCGAAGGTGGTTATGTCTGCCGGTGCTCA
GAAGGCTACCAAGGAGATGGGATTCACTGTCTTGATATTGATGAGTGCCAACTGGGGGTG
CACAGCTGTGGAGAGAATGCCAGCTGCACAAATACAGAGGGAGGCTATACCTGCATGTGT
GCTGGACGCCTGTCTGAACCAGGACTGATTTGCCCTGACTCTACTCCACCCCCTCACCTC
AGGGAAGATGACCACCACTATTCCGTAAGAAATAGTGACTCTGAATGTCCCCTGTCCCAC
GATGGGTACTGCCTCCATGATGGTGTGTGCATGTATATTGAAGCATTGGACAAGTATGCA
TGCAACTGTGTTGTTGGCTACATCGGGGAGCGATGTCAGTACCGAGACCTGAAGTGGTGG
GAACTGCGCCACGCTGGCCACGGGCAGCAGCAGAAGGTCATCGTGGTGGCTGTCTGCGTG
GTGGTGCTTGTCATGCTGCTCCTCCTGAGCCTGTGGGGGGCCCACTACTACAGGACTCAG
AAGCTGCTATCGAAAAACCCAAAGAATCCTTATGAGGAGTCGAGCAGAGATGTGAGGAGT
CGCAGGCCTGCTGACACTGAGGATGGGATGTCCTCTTGCCCTCAACCTTGGTTTGTGGTT
ATAAAAGAACACCAAGACCTCAAGAATGGGGGTCAACCAGTGGCTGGTGAGGATGGCCAG
GCAGCAGATGGGTCAATGCAACCAACTTCATGGAGGCAGGAGCCCCAGTTATGTGGAATG
GGCACAGAGCAAGGCTGCTGGATTCCAGTATCCAGTGATAAGGGCTCCTGTCCCCAGGTA
ATGGAGCGAAGCTTTCATATGCCCTCCTATGGGACACAGACCCTTGAAGGGGGTGTCGAG
AAGCCCCATTCTCTCCTATCAGCTAACCCATTATGGCAACAAAGGGCCCTGGACCCACCA
CACCAAATGGAGCTGACTCAGTGA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
X04571

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_8_Locus:
4q25

# Macromolecular_Interacting_Partner_8_SNPs:
rs2237051; rs4698803; rs11569017; rs11568943; rs9991664; rs11569046; rs35191533; rs11568992; rs11568911; rs28553469; rs11569098; rs11568849; rs2302135; rs11568937; rs11568993; rs11568885; rs11568953; rs4444903; rs11568847; rs11569146; rs3733625; rs35397046; rs11569145; rs11569147; rs2282787; rs1024600; rs2298983; rs2237053; rs881878; rs2881559; rs1024599; rs2067004; rs2190907; rs971695; rs2282784; rs1860129; rs2255355; rs882471; rs2074390; rs971696; rs2298992; rs10029654; rs2237048; rs2298998; rs6533482; rs2298986; rs2298991; rs2074391; rs3796944; rs12506362; rs1005903; rs9995637; rs6815092; rs2237054; rs6533484; rs6823529; rs4698801; rs10010695; rs1860131; rs2250616; rs7677295; rs881841; rs7655579; rs2298978; rs7692976; rs7695064; rs10470911; rs2298993; rs6825106; rs2237043; rs2347139; rs4698755; rs2250724; rs6818260; rs10857004; rs882405; rs2237047; rs6533485; rs7661766; rs6824759; rs6827914; rs11098057; rs11569069; rs2298999; rs6840890; rs4698757; rs7662362; rs2237041; rs6824594; rs929446; rs2074392; rs2282786; rs4141078; rs3822288; rs2237049; rs2237052; rs4698756; rs2074389; rs2237044; rs11098059; rs2298979; rs4698800; rs6837717; rs11098060; rs2237050; rs9307346; rs6811864; rs2298988; rs12510173; rs7661968; rs6832396; rs11568889; rs4698802; rs2190909; rs11568941; rs11098056; rs11568991; rs11568901; rs11098061; rs11568853; rs11569116; rs6810393; rs10017261; rs6854247; rs11569095; rs11098054; rs3796942; rs6836684; rs11569039; rs7685406; rs11569080; rs11568970; rs11568912; rs11098053; rs11569126; rs2298994; rs11568895; rs3216211; rs11569047; rs3733627; rs3796947; rs3822285; rs11569005; rs12640600; rs10488881; rs11569093; rs6811614; rs6836311; rs3796940; rs6811428; rs887027; rs11568946; rs3796945; rs11569134; rs3733626; rs12507356; rs9307347; rs11569057; rs11569045; rs3822287; rs4141077; rs2298987; rs6827611; rs11568866; rs11568994; rs3796943; rs2298989; rs9991904; rs11569082; rs11569121; rs11568927; rs6533483; rs7668520; rs11569115; rs11568942; rs11568898; rs3796941; rs17041111; rs11569109; rs11568850; rs7670908; rs2298977; rs3796948; rs2024114; rs10023272; rs2299001; rs10017564; rs11569021; rs11569020; rs11569092; rs12649348; rs2298982; rs6533481; rs11568959; rs6850557; rs3733628; rs10002971; rs9992755; rs11569087; rs11568975; rs11098062; rs3764861; rs3822286; rs2237045; rs9991367; rs7680062; rs10011112; rs11568961; rs11569104; rs11569105; rs3796946; rs11569033; rs7668015; rs11569090; rs11568987; rs11568926; rs11569089; rs11568874; rs11568915; rs17041036; rs11569068; rs11568969; rs11568984; rs10434002; rs11568877; rs11569100; rs11569101; rs11569061; rs11568930; rs11569077; rs10025078; rs11569078; rs17041171; rs11569103; rs11569003; rs2298997; rs11932661; rs11569124; rs17041151; rs3796949; rs11569042; rs2299000; rs11569138; rs11568957; rs2282785; rs11568954; rs10029765; rs11568860; rs11569075; rs11568904; rs11568894; rs12511518; rs11568855; rs11568974; rs11568865; rs17041117; rs2237042; rs2881560; rs17041140; rs11569008; rs11568944; rs11569055; rs11569062; rs11568929; rs10029105; rs17041119; rs11098058; rs11568903; rs11568976; rs11569070; rs11568951; rs11568958; rs11569006; rs11569023; rs11569026; rs11569013; rs10213531; rs11569118; rs11568871; rs11568905; rs11568910; rs11568897; rs11568924; rs11568938; rs11569067; rs11568979; rs11569034; rs11569049; rs11569019; rs11569099; rs11568996; rs11569085; rs11568878; rs11943900; rs17041066; rs11569084; rs2298990; rs12506702; rs11569038; rs11569114; rs11569009; rs10002835; rs11569094; rs11569043; rs11569132; rs11569130; rs2347137; rs11569140; rs11569016; rs11568966; rs6844856; rs11568931; rs11568985; rs10014383; rs11568955; rs6413482; rs11568972; rs12506078; rs11568997; rs2298996; rs11569007; rs11568902; rs10014805; rs11568856; rs11568982; rs11568893; rs11569108; rs11568880; rs11569014; rs11569074; rs11569081; rs11568875; rs11568962; rs11569041; rs11569088; rs11569102; rs11568933; rs887028; rs11568888; rs11569123; rs10025276; rs11569030; rs11568956; rs11569142; rs11568980; rs11569037; rs11568886; rs11569052; rs12503113; rs2347138; rs11568870; rs17041134; rs12504641; rs11568945; rs11568947; rs11569065; rs11569129; rs11568858; rs2298995; rs11569133; rs11568990; rs17253063; rs11569107; rs11946955; rs3216213; rs11569048; rs11568989; rs11569058; rs11568906; rs11569050; rs2347136; rs11569022; rs11569066; rs11569079; rs2237040; rs11569035; rs11568884; rs11568907; rs11568949; rs11568925; rs17041176; rs11569044; rs11568995; rs11568923; rs11568978; rs11568862; rs11569056; rs11568950; rs7653900; rs11568846; rs11568836; rs3756261; rs11098052; rs11568835; rs11569149; rs12651220; rs11568837; rs11568839; rs11568844; rs11568838; rs11568841; rs11569144; rs6413481; rs11569086; rs28592692; rs35861016; rs11569111; rs41482245; rs41456944; rs41491249; rs35179300; rs41525245; rs11568848; rs11569083; rs34035044; rs2282783; rs10032001; rs34020379; rs35323166; rs11569018; rs11569051; rs34978462; rs11569131; rs10530188; rs4631111; rs28375920; rs11568948; rs11568967; rs11569122; rs34064583; rs13132659; rs11568899; rs11569097; rs11568952; rs11569073; rs34676458; rs35764342; rs28734982; rs41475346; rs11569025; rs2298981; rs11568864; rs41391347; rs41468451; rs13124171; rs11568883; rs11736732; rs11940608; rs34313375; rs11568965; rs35219330; rs28672708; rs11568887; rs11569004; rs3834237; rs9992709; rs35202654; rs11569029; rs11568932; rs11568928; rs10018671; rs11568879; rs35756119; rs11568913; rs11569015; rs11569128; rs3831508; rs10657118; rs35889913; rs36204343; rs41434845; rs34678383; rs11568892; rs11568881; rs11569000; rs11568876; rs41408447; rs12506489; rs28599924; rs35965393; rs11569036; rs36096733; rs11568917; rs11569136; rs35111701; rs11569106; rs13130517; rs28846451; rs13114846; rs28405885; rs35137507; rs11568859; rs35433114; rs35063848; rs35123785; rs11568867; rs13122091; rs11569120; rs11568988; rs11568977; rs11569040; rs33988828; rs34794044; rs11569112; rs7688334; rs28535066; rs11568998; rs11569119; rs11568857; rs33911213; rs28684716; rs11569032; rs11568934; rs11568852; rs41472549; rs35449393; rs34093217; rs11569143; rs11568960; rs36023559; rs41521844; rs33928953; rs34076404; rs36009201; rs11569064; rs34766103; rs34244718; rs2298985; rs28372160; rs11568861; rs11569053; rs11568890; rs13104254; rs11569072; rs34428348; rs13122083; rs35860692; rs35967976; rs35386224; rs35014139; rs41468551; rs34240890; rs34548988; rs2237046; rs11301315; rs34620819; rs41481750; rs11568919; rs41391155; rs35885486; rs35556509; rs11568936; rs11569011; rs10657058; rs35573075; rs11568900; rs41535246; rs33963140; rs11568863; rs11569076; rs11568854; rs28889289; rs28629923; rs11569096; rs41319247; rs35654533; rs10716107; rs11568964; rs11569091; rs28437404; rs11569001; rs2347135; rs28415968; rs11569002; rs11568999; rs34595076; rs2282782; rs28387677; rs28540029; rs41397647; rs11568873; rs11569127; rs11568882; rs3216212; rs882481; rs41353547; rs11301294; rs41421149; rs10649107; rs35122992; rs35428416; rs11569024; rs11568920; rs11569137; rs41471646; rs41335052; rs41412848; rs10027781; rs41335844; rs34890313; rs11569060; rs11568916; rs28825186; rs28642082; rs12374273; rs34223898; rs4279279; rs28471982; rs28729403; rs7699332; rs28662394; rs28888150; rs10015673; rs11568909; rs11569063; rs11568891; rs4273533; rs11433360; rs35339403; rs41335850; rs33925807; rs11569012; rs41322950; rs11568918; rs11569135; rs7666676; rs34888284; rs11568922; rs41494548; rs34482188; rs28803170; rs11569125; rs11568983; rs41505549; rs34071188; rs41508755; rs11569028; rs11568914; rs11568973; rs7668040; rs11568968; rs41475451; rs35408481; rs11569110; rs41464250; rs11568921; rs11568851; rs11568963; rs33995517; rs41496247; rs35810695; rs11569031; rs11569117; rs13129198; rs35517861; rs4510519; rs12502241; rs2881676; rs35170625; rs35632667; rs11568896; rs34339522; rs11569010; rs5860995; rs41478647; rs41356844; rs11569054; rs11433359; rs11568939; rs11402023; rs35084748; rs35383133; rs36052471; rs12502303; rs11569071; rs11568869; rs11568868; rs2298980; rs35394297; rs41350346; rs41501344; rs35310520; rs34611531; rs11568986; rs3775967; rs11568935; rs34109657; rs35410996; rs34785015; rs28719677; rs35249603; rs28414645; rs41336144; rs28564978; rs11287078; rs35647377; rs41528446; rs36139444; rs41402448; rs6413480; rs11568940; rs11568971; rs12648345; rs41433946; rs2298984; rs35889237; rs2299002; rs35892263; rs28687523; rs11568872; rs35368137; rs6823639; rs35699323; rs11569027; rs36055865; rs34977252; rs11569113; rs35531982; rs11387205; rs41498148; rs11569150; rs11568843; rs41492947; rs41454845; rs34481940; rs3756262; rs41475745; rs41403346; rs41455350; rs11569148; rs11568842; rs41475347; rs11568845; rs10708667; rs3756263; rs41344446; rs11568840; rs36074341; rs10021157; rs10021246; rs10021697; rs10021804; rs11098063; rs11569151; rs11569152; rs11569153; rs11569154; rs11569155; rs11569158; rs11569159; rs11569160; rs11569161; rs13149341; rs17040989; rs17040990; rs17041230; rs17238095; rs17316633; rs3756266; rs3756267; rs4698804; rs718768; rs7698924; rs7699288; rs9991044; rs9993323; rs9999824

# Macromolecular_Interacting_Partner_8_General_References:
3491360; 300079; 2789514; 1522591

# Macromolecular_Interacting_Partner_8_References:
2808338; 7688570

# Macromolecular_Interacting_Partner_9_ID:
8444

# Macromolecular_Interacting_Partner_9_Name:
Transforming growth factor beta-1 precursor

# Macromolecular_Interacting_Partner_9_Synonyms:
TGF-beta-1[Contains: Latency-associated peptide; LAP]

# Macromolecular_Interacting_Partner_9_Gene_Name:
TGFB1

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Transforming growth factor beta1 precursor
MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI
YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR
YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT
TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI
DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA
LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
390

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
44342

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
8.63

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  growth factor activity
Function:  signal transducer activity
Function:  receptor binding
Function:  transforming growth factor beta receptor binding
 ||
>>>
Process:  growth
Process:  cell growth
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Multifunctional protein that control proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGFB1 and essentially all of them have specific receptors for this protein. It regulates the actions of many other growth factors and determines a positive or negative direction of their effects. It plays an important role in bone remodelling. It is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00019:TGF_beta;
PF00688:TGFb_propeptide

# Macromolecular_Interacting_Partner_9_Signals:
1-29

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
1212989

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
TGFB1_HUMAN (P01137)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
TGFB1

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
TGFB1

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:11766

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>355 bp
ATGCCGCCCTCCGGGCTGCGGCTGCTGCTGCTGCTGCTACCGCTGCTGTGGCTACTGGTG
CTGACGCCTGGCCGGCCGGCCGCGGGACTATCCACCTGCAAGACTATCGACATGGAGCTG
GTGAAGCGGAAGCGCATCGAGGCCATCCGCGGCCAGATCCTGTCCAAGCTGCGGCTCGCC
AGCCCCCCGAGCCAGGGGGAGGTGCCGCCCGGCCCGCTGCCCGAGGCCGTGCTCGCCCTG
TACAACAGCACCCGCGACCGGGTGGCCGGGGAGAGTGCAGAACCGGAGCCCGAGCCTGAG
GCCGACTACTACGCCAAGGAGGTCACCCGCGTGCTAATGGTGGAAACCCACAACG

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
X05839

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_9_Locus:
19q13.2|19q13.1

# Macromolecular_Interacting_Partner_9_SNPs:
rs1982073; rs1800472; rs1800471; rs9282871; rs11466316; rs11466315; rs2241717; rs7408955; rs2278422; rs13306709; rs7258445; rs2288873; rs747857; rs8110090; rs11466329; rs2288874; rs11466347; rs2241716; rs8179181; rs8102501; rs11466345; rs8105161; rs6508976; rs4803455; rs1989457; rs11466338; rs10405403; rs8108052; rs2241715; rs11466335; rs11466357; rs12461895; rs6508975; rs11466337; rs11466351; rs11466344; rs12462166; rs11466331; rs11466341; rs11466324; rs11466359; rs11466318; rs10420084; rs11466356; rs11466343; rs11466321; rs1549934; rs10406816; rs11466334; rs11466349; rs10416269; rs11466353; rs8179182; rs13447341; rs35383147; rs11466358; rs11551225; rs11551223; rs12977601; rs12985978; rs13306707; rs11551226; rs36102838; rs13306706; rs35025994; rs12977628; rs13306708; rs11466354; rs11466330; rs7249191; rs35169655; rs11466327; rs11466355; rs8102918; rs9749548; rs12983775; rs5828100; rs3061187; rs41275752; rs12979815; rs35276753; rs35019416; rs3061188; rs2288875; rs3061192; rs5828102; rs28730295; rs12976890; rs35312206; rs11466333; rs33950017; rs11403932; rs11466340; rs11331966; rs3061190; rs2014015; rs11466328; rs11672143; rs35976994; rs5828101; rs11466346; rs10418010; rs8108632; rs35676663; rs35197353; rs11466352; rs11307639; rs11347492; rs12980944; rs11367425; rs36050346; rs34368921; rs8103575; rs11466350; rs11466342; rs12978333; rs11466320; rs11466348; rs41333448; rs34971127; rs11673275; rs11466336; rs28769597; rs11466339; rs5828099; rs10406316; rs12976219; rs34233206; rs10417924; rs1054797; rs11083616; rs11304; rs11668109; rs11668308; rs11669342; rs11879777; rs12980298; rs12980942; rs12981053; rs12983047; rs16959007; rs1800468; rs1800469; rs1800820; rs1982072; rs2241712; rs2241713; rs2241714; rs2241718; rs2241719; rs2241720; rs34088631; rs35135271; rs3810173; rs4803454; rs6957; rs7257310; rs7257742

# Macromolecular_Interacting_Partner_9_General_References:
3470709; 3861940; 8471846; 2982829; 3162913; 9150447; 11746498; 8424942; 8424943; 8679613; 9783545; 10973241; 11062463; 12202987; 12493741; 12843182

# Macromolecular_Interacting_Partner_9_References:
11561872; 1370602; 1371050; 1702100

# Macromolecular_Interacting_Partner_10_ID:
8080

# Macromolecular_Interacting_Partner_10_Name:
Beta-nerve growth factor precursor

# Macromolecular_Interacting_Partner_10_Synonyms:
Beta-NGF

# Macromolecular_Interacting_Partner_10_Gene_Name:
NGFB

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Betanerve growth factor precursor
MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIA
ARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSK
RSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCR
DPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRR
A

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
241

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
26959

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
10.54

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00243:NGF

# Macromolecular_Interacting_Partner_10_Signals:
1-18

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
671883

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
NGF_HUMAN (P01138)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
NGFB

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
NGFB

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:7808

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>726 bp
ATGTCCATGTTGTTCTACACTCTGATCACAGCTTTTCTGATCGGCATACAGGCGGAACCA
CACTCAGAGAGCAATGTCCCTGCAGGACACACCATCCCCCAAGTCCACTGGACTAAACTT
CAGCATTCCCTTGACACTGCCCTTCGCAGAGCCCGCAGCGCCCCGGCAGCGGCGATAGCT
GCACGCGTGGCGGGGCAGACCCGCAACATTACTGTGGACCCCAGGCTGTTTAAAAAGCGG
CGACTCCGTTCACCCCGTGTGCTGTTTAGCACCCAGCCTCCCCGTGAAGCTGCAGACACT
CAGGATCTGGACTTCGAGGTCGGTGGTGCTGCCCCCTTCAACAGGACTCACAGGAGCAAG
CGGTCATCATCCCATCCCATCTTCCACAGGGGCGAATTCTCGGTGTGTGACAGTGTCAGC
GTGTGGGTTGGGGATAAGACCACCGCCACAGACATCAAGGGCAAGGAGGTGATGGTGTTG
GGAGAGGTGAACATTAACAACAGTGTATTCAAACAGTACTTTTTTGAGACCAAGTGCCGG
GACCCAAATCCCGTTGACAGCGGGTGCCGGGGCATTGACTCAAAGCACTGGAACTCATAT
TGTACCACGACTCACACCTTTGTCAAGGCGCTGACCATGGATGGCAAGCAGGCTGCCTGG
CGGTTTATCCGGATAGATACGGCCTGTGTGTGTGTGCTCAGCAGGAAGGCTGTGAGAAGA
GCCTGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
V01511

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_10_Locus:
1p13.1

# Macromolecular_Interacting_Partner_10_SNPs:
rs6330; rs11466110; rs11466111; rs6325; rs1318345; rs2747058; rs719452; rs2179926; rs2254404; rs2856813; rs910330; rs2239622; rs10776800; rs2254527; rs3811015; rs4332358; rs10776798; rs4454548; rs4839028; rs4073129; rs4076194; rs4839435; rs4146585; rs6678788; rs4839436; rs6326; rs12082544; rs6328; rs6698675; rs7540561; rs6537860; rs4240542; rs7544068; rs4529705; rs7542555; rs4075872; rs11102929; rs2747063; rs10745349; rs7535026; rs10776799; rs2268792; rs6673867; rs4565713; rs4626883; rs2268793; rs4076018; rs2300692; rs6331; rs6686615; rs10858075; rs12402406; rs11466098; rs17540656; rs4573519; rs10858072; rs10489530; rs12060354; rs7516191; rs11466100; rs11102924; rs7530686; rs3730194; rs2856811; rs10776797; rs12026714; rs11102925; rs17033706; rs7513144; rs4298728; rs17033692; rs17033685; rs10442682; rs11102919; rs12067817; rs4382725; rs4567277; rs3738701; rs11102917; rs11466085; rs11102926; rs7544163; rs7523654; rs17033688; rs10858074; rs4634908; rs2300694; rs7520839; rs11466069; rs11466104; rs11466091; rs11466073; rs4240543; rs11466103; rs11466089; rs11466083; rs11466102; rs12026809; rs11102920; rs12145726; rs12048019; rs11466076; rs11102916; rs11466070; rs10442681; rs6678898; rs11466068; rs11466075; rs12061479; rs7415422; rs11466099; rs7555016; rs11466093; rs6658541; rs11466077; rs17033622; rs11466079; rs11466095; rs2300693; rs11466094; rs4623700; rs10858071; rs11466106; rs11466109; rs12058002; rs11466097; rs11466074; rs3811016; rs12061661; rs17033680; rs2300695; rs11466108; rs4644491; rs11102922; rs4406631; rs12058927; rs11466072; rs12091513; rs12060360; rs11466071; rs4298730; rs11466081; rs11466086; rs10858073; rs11466080; rs11102921; rs11102927; rs7536097; rs12760036; rs11102918; rs11466087; rs11466096; rs11466084; rs4320778; rs11584438; rs4348722; rs4456091; rs4839434; rs6329; rs7417254; rs11466088; rs10158276; rs4240544; rs11466082; rs3811014; rs10776801; rs11102930; rs11466113; rs11466066; rs11466063; rs11466065; rs11466062; rs34542615; rs28758211; rs11466112; rs34079702; rs35941329; rs11466092; rs12727497; rs35833423; rs11579116; rs35290932; rs11302114; rs2284830; rs12749420; rs3730184; rs28645283; rs2747059; rs11466090; rs35070942; rs11102923; rs12088144; rs35067920; rs11102928; rs11580846; rs35755250; rs11466107; rs34024301; rs12023088; rs28735771; rs28461336; rs11579131; rs34357271; rs34257515; rs11579114; rs35884898; rs12025459; rs12119346; rs35221274; rs35274060; rs12073677; rs12070188; rs11584424; rs35329343; rs34377570; rs11485078; rs3730215; rs35658308; rs3021067; rs4417063; rs12731678; rs2747061; rs35447405; rs12047130; rs11579133; rs13374803; rs35225488; rs9970214; rs719451; rs7528234; rs2747056; rs2856814; rs10157426; rs12731680; rs11466078; rs2747055; rs35917469; rs35011726; rs35337130; rs35044546; rs17033682; rs28505352; rs34063775; rs2856812; rs35439338; rs11466105; rs34845120; rs11586039; rs34042023; rs35071824; rs34402529; rs2747057; rs11466114; rs35603764; rs11466064; rs11466061; rs11466067; rs34611363; rs3841009; rs10776802; rs10858076; rs10858077; rs10858078; rs11102915; rs11102932; rs11466059; rs11583020; rs11805062; rs11807499; rs12074502; rs12075799; rs12085129; rs12139760; rs12723944; rs1474798; rs1535093; rs1555207; rs17033589; rs17033597; rs17033602; rs17033725; rs2068797; rs2982740; rs2982741; rs2982742; rs3014804; rs4073110; rs4131272; rs4131273; rs4310443; rs4418592; rs4504888; rs4839029; rs4839030; rs4839031; rs6327; rs6656381; rs6657711; rs6676284; rs6678944; rs6691765; rs7416420; rs7523086; rs7523831; rs7532754; rs7544256; rs926781

# Macromolecular_Interacting_Partner_10_General_References:
6688123; 6327169; 2374737; 10322959; 2025430; 10391209

# Macromolecular_Interacting_Partner_10_References:
1374478; 9780213

# Macromolecular_Interacting_Partner_11_ID:
8272

# Macromolecular_Interacting_Partner_11_Name:
Pregnancy zone protein precursor

# Macromolecular_Interacting_Partner_11_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_11_Gene_Name:
PZP

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Pregnancy zone protein precursor
MRKDRLLHLCLVLLLILLSASDSNSTEPQYMVLVPSLLHTEAPKKGCVLLSHLNETVTVS
ASLESGRENRSLFTDLVAEKDLFHCVSFTLPRISASSEVAFLSIQIKGPTQDFRKRNTVL
VLNTQSLVFVQTDKPMYKPGQTVRFRVVSVDENFRPRNELIPLIYLENPRRNRIAQWQSL
KLEAGINQLSFPLSSEPIQGSYRVVVQTESGGRIQHPFTVEEFVLPKFEVKVQVPKIISI
MDEKVNITVCGEYTYGKPVPGLATVSLCRKLSRVLNCDKQEVCEEFSQQLNSNGCITQQV
HTKMLQITNTGFEMKLRVEARIREEGTDLEVTANRISEITNIVSKLKFVKVDSHFRQGIP
FFAQVLLVDGKGVPIPNKLFFISVNDANYYSNATTNEQGLAQFSINTTSISVNKLFVRVF
TVHPNLCFHYSWVAEDHQGAQHTANRVFSLSGSYIHLEPVAGTLPCGHTETITAHYTLNR
QAMGELSELSFHYLIMAKGVIVRSGTHTLPVESGDMKGSFALSFPVESDVAPIARMFIFA
ILPDGEVVGDSEKFEIENCLANKVDLSFSPAQSPPASHAHLQVAAAPQSLCALRAVDQSV
LLMKPEAELSVSSVYNLLTVKDLTNFPDNVDQQEEEQGHCPRPFFIHNGAIYVPLSSNEA
DIYSFLKGMGLKVFTNSKIRKPKSCSVIPSVSAGAVGQGYYGAGLGVVERPYVPQLGTYN
VIPLNNEQSSGPVPETVRSYFPETWIWELVAVNSSGVAEVGVTVPDTITEWKAGAFCLSE
DAGLGISSTASLRAFQPFFVELTMPYSVIRGEVFTLKATVLNYLPKCIRVSVQLKASPAF
LASQNTKGEESYCICGSERQTLSWTVTPKTLGNVNFSVSAEAMQSLELCGNEVVEVPEIK
RKDTVIKTLLVEAEGIEQEKTFSSMTCASGANVSEQLSLKLPSNVVKESARASFSVLGDI
LGSAMQNIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQR
QLNYKHQDGSYSTFGERYGRNQGNTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQ
KDNGCFRSSGSLLNNAIKGGVEDEATLSAYVTIALLEIPLPVTNPIVRNALFCLESAWNV
AKEGTHGSHVYTKALLAYAFSLLGKQNQNREILNSLDKEAVKEDNLVHWERPQRPKAPVG
HLYQTQAPSAEVEMTSYVLLAYLTAQPAPTSGDLTSATNIVKWIMKQQNAQGGFSSTQDT
VVALHALSRYGAATFTRTEKTAQVTVQDSQTFSTNFQVDNNNLLLLQQISLPELPGEYVI
TVTGERCVYLQTSMKYNILPEKEDSPFALKVQTVPQTCDGHKAHTSFQISLTISYTGNRP
ASNMVIVDVKMVSGFIPLKPTVKMLERSSSVSRTEVSNNHVLIYVEQVTNQTLSFSFMVL
QDIPVGDLKPAIVKVYDYYETDESVVAEYIAPCSTDTEHGNV

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
1482

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
163838

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
6.33

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  protease inhibitor activity
Function:  endopeptidase inhibitor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_11_General_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Specific_Function:
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF00207:A2M;
PF07678:A2M_comp;
PF01835:A2M_N;
PF07703:A2M_N_2;
PF07677:A2M_recep

# Macromolecular_Interacting_Partner_11_Signals:
1-25

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
35825

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
PZP_HUMAN (P20742)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
PZP

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
PZP

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:9750

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>4449 bp
ATGCGGAAAGACAGACTTCTTCATTTATGTCTTGTGCTACTTCTTATCCTGCTTTCTGCC
AGTGACTCAAACTCTACAGAACCGCAGTATATGGTGCTGGTCCCCTCCCTGCTCCACACT
GAGGCCCCTAAGAAGGGCTGTGTCCTTCTGAGCCACCTGAATGAGACAGTGACTGTAAGT
GCTTCCTTGGAGTCTGGCAGGGAAAACAGGAGCCTCTTCACTGACCTGGTGGCGGAGAAG
GACTTATTCCACTGTGTCTCCTTCACTCTCCCAAGGATCTCAGCCTCTTCAGAGGTGGCA
TTCCTTAGCATCCAGATAAAGGGGCCTACGCAAGATTTCAGGAAGAGGAACACAGTTCTG
GTACTGAACACCCAAAGTCTGGTCTTTGTCCAGACAGACAAACCCATGTATAAACCAGGA
CAGACAGTAAGATTCCGTGTTGTCTCCGTGGATGAAAATTTTCGCCCTCGAAATGAACTG
ATTCCACTGATATACCTTGAGAACCCAAGAAGAAATCGAATTGCACAATGGCAGAGTCTC
AAGCTAGAAGCTGGCATCAATCAGTTGTCCTTTCCCCTCTCATCAGAGCCCATTCAGGGC
TCCTACAGGGTGGTGGTACAGACAGAATCAGGTGGAAGGATACAGCACCCCTTCACCGTG
GAGGAATTTGTGCTTCCCAAGTTTGAGGTCAAAGTTCAGGTGCCAAAGATAATCAGTATC
ATGGATGAAAAAGTGAACATAACAGTCTGTGGAGAATACACTTATGGGAAGCCTGTCCCA
GGACTTGCAACTGTGAGCCTGTGTAGAAAATTATCTCGTGTTCTTAATTGTGACAAGCAG
GAGGTCTGTGAGGAATTCAGTCAACAGCTTAACAGCAATGGCTGCATCACCCAACAAGTA
CACACCAAAATGCTCCAGATTACAAATACGGGCTTTGAAATGAAGCTTAGAGTGGAAGCC
AGGATCAGAGAAGAGGGGACAGACCTGGAAGTCACTGCAAACAGGATCAGTGAAATCACA
AACATTGTATCCAAACTCAAATTCGTGAAAGTGGATTCACACTTTAGACAAGGAATCCCC
TTTTTTGCACAGGTGCTTCTGGTGGATGGAAAAGGTGTGCCCATCCCCAATAAACTCTTC
TTCATCTCTGTGAATGACGCCAATTATTACTCCAATGCAACCACCAATGAGCAGGGTCTT
GCACAGTTTTCAATCAATACTACCAGTATCTCGGTTAATAAACTTTTTGTCCGGGTTTTC
ACTGTGCATCCCAACTTGTGTTTTCACTATTCATGGGTAGCAGAAGACCACCAGGGCGCT
CAGCACACTGCAAATCGTGTTTTCTCCTTAAGTGGAAGTTACATTCACCTGGAGCCTGTG
GCTGGTACCCTGCCCTGTGGCCACACGGAGACTATCACGGCACACTATACACTGAATAGA
CAGGCCATGGGAGAGTTATCGGAGCTCAGTTTCCATTACCTGATCATGGCTAAGGGAGTC
ATCGTCAGATCTGGAACCCACACTCTGCCTGTGGAGTCAGGAGACATGAAAGGCAGTTTT
GCCTTATCCTTCCCTGTGGAGTCAGACGTTGCCCCCATTGCACGAATGTTCATCTTTGCC
ATTTTACCAGATGGAGAAGTTGTTGGAGACTCTGAAAAATTTGAGATTGAAAACTGTCTA
GCCAACAAGGTGGATTTGAGCTTCAGCCCAGCACAAAGTCCCCCAGCCTCACATGCCCAC
CTGCAAGTAGCAGCTGCTCCGCAGTCCCTCTGTGCCCTTCGTGCTGTGGACCAAAGTGTG
CTGCTCATGAAGCCTGAGGCTGAGCTCTCTGTGTCCTCAGTATATAATCTGCTAACTGTG
AAGGATCTCACCAATTTTCCTGACAATGTGGACCAGCAGGAGGAAGAACAAGGACACTGT
CCCCGTCCTTTCTTCATTCATAATGGAGCCATCTATGTTCCCTTATCAAGTAATGAAGCA
GATATTTATAGCTTCCTCAAGGGGATGGGATTGAAGGTGTTCACTAACTCAAAAATCCGA
AAACCAAAGTCGTGTTCAGTCATCCCTTCCGTGTCTGCAGGAGCAGTAGGTCAAGGATAC
TATGGAGCAGGTCTAGGAGTAGTAGAGAGACCATATGTTCCTCAATTAGGCACATATAAT
GTGATACCCTTAAATAATGAACAAAGTTCAGGGCCAGTCCCTGAAACGGTGCGAAGCTAT
TTTCCTGAGACTTGGATCTGGGAGTTGGTGGCAGTGAACTCATCAGGTGTGGCTGAGGTA
GGAGTAACAGTCCCTGACACCATCACCGAGTGGAAGGCAGGGGCCTTCTGCCTGTCTGAA
GATGCTGGACTTGGTATCTCTTCCACTGCCTCTCTCCGAGCCTTCCAGCCCTTCTTTGTG
GAGCTCACAATGCCTTACTCTGTGATTCGTGGAGAGGTCTTCACACTCAAGGCCACGGTC
CTAAACTACCTTCCCAAATGCATCCGGGTCAGTGTGCAGCTGAAAGCCTCTCCAGCCTTC
CTAGCTTCCCAAAATACAAAGGGAGAAGAATCCTATTGTATCTGTGGAAGTGAGAGACAA
ACCTTGTCTTGGACAGTGACTCCTAAAACTCTGGGGAATGTGAACTTCTCAGTGAGTGCA
GAGGCAATGCAGTCCTTAGAACTCTGTGGAAATGAGGTTGTTGAGGTCCCTGAGATTAAA
AGAAAAGACACAGTCATCAAAACCCTGTTGGTGGAGGCTGAAGGTATTGAGCAAGAAAAG
ACTTTCAGTTCCATGACCTGTGCCTCAGGTGCTAATGTGTCTGAGCAGTTGTCCTTGAAG
CTCCCATCAAATGTGGTCAAAGAATCTGCCAGAGCTTCTTTCTCAGTTCTGGGTGACATA
TTAGGTTCTGCTATGCAAAATATACAAAATCTCCTCCAGATGCCATATGGCTGTGGAGAA
CAGAACATGGTCCTATTTGCTCCTAACATCTATGTCTTGAACTATCTGAATGAAACCCAG
CAGCTGACGCAGGAGATCAAGGCCAAGGCCGTTGGCTATCTCATCACTGGTTACCAGAGA
CAGCTGAACTACAAACACCAAGATGGCTCCTACAGCACCTTTGGGGAACGATATGGCAGG
AACCAGGGCAACACTTGGCTCACAGCTTTTGTACTGAAGACTTTCGCCCAGGCTCGATCC
TACATCTTCATTGATGAAGCACACATTACCCAATCTCTCACGTGGCTCTCCCAGATGCAG
AAGGACAATGGCTGTTTCAGGAGCTCTGGGTCACTGCTCAACAATGCCATAAAGGGAGGT
GTAGAAGATGAAGCGACCCTCTCCGCCTATGTTACTATTGCCCTTCTGGAAATTCCTCTC
CCAGTCACTAACCCTATTGTTCGCAATGCCCTGTTCTGCCTGGAGTCAGCCTGGAATGTA
GCAAAGGAGGGGACCCATGGGAGCCATGTCTACACCAAGGCATTGCTGGCCTATGCTTTT
TCCCTACTGGGAAAGCAAAATCAGAATAGAGAAATACTGAACTCACTTGATAAGGAAGCT
GTGAAAGAAGACAACCTCGTCCATTGGGAGCGCCCTCAGAGACCCAAGGCACCAGTGGGG
CATCTTTACCAAACCCAGGCTCCCTCTGCTGAGGTGGAGATGACATCCTATGTGCTCCTC
GCTTATCTCACGGCCCAGCCAGCCCCCACCTCAGGGGACCTGACCTCTGCAACTAACATT
GTGAAGTGGATCATGAAGCAGCAGAACGCCCAAGGTGGTTTCTCCTCCACCCAGGACACA
GTGGTGGCTCTCCATGCCCTGTCCAGGTATGGAGCAGCCACTTTCACCAGAACTGAGAAA
ACTGCACAGGTCACCGTTCAGGATTCACAGACCTTTTCTACAAATTTCCAAGTAGACAAC
AACAACCTCCTATTACTGCAGCAGATCTCATTGCCAGAGCTCCCTGGAGAATATGTCATA
ACAGTAACTGGGGAAAGATGTGTGTATCTTCAGACATCCATGAAATACAATATTCTTCCA
GAGAAAGAGGACTCCCCATTTGCTTTAAAAGTGCAGACTGTGCCCCAGACTTGCGATGGA
CACAAAGCCCACACCAGCTTTCAGATCTCACTGACCATCAGTTACACAGGAAACCGTCCT
GCTTCCAATATGGTGATTGTTGATGTAAAGATGGTATCTGGTTTTATTCCCCTGAAACCA
ACAGTAAAAATGCTTGAAAGATCTAGCTCTGTGAGCCGGACAGAAGTGAGCAACAACCAT
GTCCTCATTTATGTGGAACAGGTGACAAATCAGACGCTAAGTTTTTCCTTCATGGTTCTG
CAAGACATCCCAGTAGGAGACTTGAAGCCAGCAATTGTTAAAGTCTATGATTACTATGAG
ACAGATGAGTCTGTGGTTGCTGAGTATATCGCCCCCTGCAGCACAGATACAGAGCATGGA
AATGTTTGA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
X54380

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_11_Locus:
12p13-p12.2

# Macromolecular_Interacting_Partner_11_SNPs:
rs2277413; rs3213831; rs10842971; rs3213832; rs2377741; rs12230214; rs10771357; rs10771381; rs3741849; rs2277412; rs10771407; rs16918152; rs34427370; rs919209; rs2195208; rs2114851; rs2075395; rs1863839; rs2303615; rs6487650; rs3759276; rs7954068; rs11049343; rs3741850; rs10771404; rs2075394; rs10771386; rs10771412; rs4140706; rs3782677; rs7309821; rs7964970; rs7970135; rs7306859; rs10771418; rs4882983; rs6487636; rs10743614; rs3741851; rs4882982; rs4883215; rs11049351; rs7309811; rs3759274; rs7298673; rs2114847; rs12423745; rs3741852; rs4882981; rs7298213; rs11049326; rs4140705; rs7311982; rs2195207; rs6487662; rs7137886; rs7136652; rs2114848; rs11049296; rs10843050; rs6487639; rs7138080; rs2377745; rs12823677; rs7968120; rs11049325; rs4883221; rs10771413; rs11615443; rs7976807; rs10771415; rs12822596; rs11049321; rs11608867; rs1863838; rs6487668; rs10843089; rs11049333; rs10843046; rs7298117; rs16861; rs11049235; rs11049331; rs12298908; rs4883219; rs11049314; rs12321232; rs7968679; rs7298246; rs7138416; rs16918159; rs10843043; rs3759275; rs10743616; rs11833495; rs16918120; rs11836204; rs7312604; rs7980965; rs10492114; rs7304882; rs10843044; rs16918162; rs7295453; rs10843036; rs12318701; rs11502735; rs2114852; rs11611803; rs11611826; rs6487666; rs11049330; rs1968354; rs1863840; rs7959200; rs7303319; rs3782676; rs7959534; rs7294811; rs7972015; rs2889718; rs2114849; rs12308213; rs10842970; rs7305469; rs2377743; rs7311066; rs11612110; rs1035848; rs6487633; rs10843149; rs1017301; rs7971847; rs1035849; rs17794353; rs17202253; rs10842969; rs11611335; rs35213971; rs35916777; rs35989918; rs35040316; rs35095552; rs34391731; rs34502103; rs34723854; rs7133326; rs34945701; rs7957230; rs12422480; rs12821718; rs11049404; rs35535297; rs7965958; rs5796340; rs10540786; rs34388882; rs11451689; rs2377746; rs7956661; rs12307479; rs34241170; rs12316611; rs12308489; rs35024258; rs876387; rs35927804; rs34858682; rs36052925; rs7298621; rs35009626; rs35749332; rs11049456; rs5796341; rs12315060; rs4012634; rs10616028; rs2377742; rs35911674; rs11532270; rs4012635; rs34467991; rs34308848; rs876386; rs35719317; rs2081795; rs34970014; rs7959360; rs3046340; rs12823018; rs10842982; rs34409478; rs10708091; rs11049452; rs34499203; rs34238125; rs4883220; rs12297865; rs34466292; rs11423699; rs12305427; rs35757574; rs10843142; rs12819945; rs12371473; rs34312998; rs3832849; rs11049408; rs6487641; rs7978819; rs10697653; rs35281647; rs11398106; rs34223218; rs35054413; rs12303017; rs11471363; rs2377744; rs35113306; rs11049348; rs34212184; rs11049379; rs35758277; rs35556437; rs12315289; rs11049396; rs7977644; rs12371130; rs11049267; rs10843144; rs5796342; rs41393747; rs34619007; rs876388; rs12814448; rs17730999; rs34228105; rs34432003; rs10606553; rs5796343; rs10550947; rs1017302; rs10843160; rs11049542; rs12302819; rs12322616; rs12823877; rs12824090; rs2377747; rs4367994; rs7979115

# Macromolecular_Interacting_Partner_11_General_References:
1989698; 2476433; 1692292; 2415522; 2478422; 2692707

# Macromolecular_Interacting_Partner_11_References:
12237864; 2692707; 7687148; 9268676

# Macromolecular_Interacting_Partner_12_ID:
7992

# Macromolecular_Interacting_Partner_12_Name:
Beta-secretase 1 precursor

# Macromolecular_Interacting_Partner_12_Synonyms:
Beta-site APP cleaving enzyme 1; Beta-site amyloid precursor protein cleaving enzyme 1; Membrane-associated aspartic protease 2; Memapsin-2; Aspartyl protease 2; Asp 2; ASP2

# Macromolecular_Interacting_Partner_12_Gene_Name:
BACE1

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Betasecretase 1 precursor
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
501

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
55764

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
5.19

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  pepsin A activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  aspartic-type endopeptidase activity
Function:  aspartic-type signal peptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF00026:Asp

# Macromolecular_Interacting_Partner_12_Signals:
1-21

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
458-478

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
EC 3.4.23.46

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
6118539

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
BACE1_HUMAN (P56817)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
BACE1

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
BACE1

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:933

# Macromolecular_Interacting_Partner_12_PDB_ID:
1W51

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>1506 bp
ATGGCCCAAGCCCTGCCCTGGCTCCTGCTGTGGATGGGCGCGGGAGTGCTGCCTGCCCAC
GGCACCCAGCACGGCATCCGGCTGCCCCTGCGCAGCGGCCTGGGGGGCGCCCCCCTGGGG
CTGCGGCTGCCCCGGGAGACCGACGAAGAGCCCGAGGAGCCCGGCCGGAGGGGCAGCTTT
GTGGAGATGGTGGACAACCTGAGGGGCAAGTCGGGGCAGGGCTACTACGTGGAGATGACC
GTGGGCAGCCCCCCGCAGACGCTCAACATCCTGGTGGATACAGGCAGCAGTAACTTTGCA
GTGGGTGCTGCCCCCCACCCCTTCCTGCATCGCTACTACCAGAGGCAGCTGTCCAGCACA
TACCGGGACCTCCGGAAGGGTGTGTATGTGCCCTACACCCAGGGCAAGTGGGAAGGGGAG
CTGGGCACCGACCTGGTAAGCATCCCCCATGGCCCCAACGTCACTGTGCGTGCCAACATT
GCTGCCATCACTGAATCAGACAAGTTCTTCATCAACGGCTCCAACTGGGAAGGCATCCTG
GGGCTGGCCTATGCTGAGATTGCCAGGCCTGACGACTCCCTGGAGCCTTTCTTTGACTCT
CTGGTAAAGCAGACCCACGTTCCCAACCTCTTCTCCCTGCAGCTTTGTGGTGCTGGCTTC
CCCCTCAACCAGTCTGAAGTGCTGGCCTCTGTCGGAGGGAGCATGATCATTGGAGGTATC
GACCACTCGCTGTACACAGGCAGTCTCTGGTATACACCCATCCGGCGGGAGTGGTATTAT
GAGGTGATCATTGTGCGGGTGGAGATCAATGGACAGGATCTGAAAATGGACTGCAAGGAG
TACAACTATGACAAGAGCATTGTGGACAGTGGCACCACCAACCTTCGTTTGCCCAAGAAA
GTGTTTGAAGCTGCAGTCAAATCCATCAAGGCAGCCTCCTCCACGGAGAAGTTCCCTGAT
GGTTTCTGGCTAGGAGAGCAGCTGGTGTGCTGGCAAGCAGGCACCACCCCTTGGAACATT
TTCCCAGTCATCTCACTCTACCTAATGGGTGAGGTTACCAACCAGTCCTTCCGCATCACC
ATCCTTCCGCAGCAATACCTGCGGCCAGTGGAAGATGTGGCCACGTCCCAAGACGACTGT
TACAAGTTTGCCATCTCACAGTCATCCACGGGCACTGTTATGGGAGCTGTTATCATGGAG
GGCTTCTACGTTGTCTTTGATCGGGCCCGAAAACGAATTGGCTTTGCTGTCAGCGCTTGC
CATGTGCACGATGAGTTCAGGACGGCAGCGGTGGAAGGCCCTTTTGTCACCTTGGACATG
GAAGACTGTGGCTACAACATTCCACAGACAGATGAGTCAACCCTCATGACCATAGCCTAT
GTCATGGCTGCCATCTGCGCCCTCTTCATGCTGCCACTCTGCCTCATGGTGTGTCAGTGG
CGCTGCCTCCGCTGCCTGCGCCAGCAGCATGATGACTTTGCTGATGACATCTCCCTGCTG
AAGTGA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
AF190725

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_12_Locus:
11q23.2-q23.3

# Macromolecular_Interacting_Partner_12_SNPs:
rs539765; rs638405; rs535860; rs481285; rs28989514; rs28989511; rs1047964; rs649555; rs28989517; rs1047857; rs28989506; rs687740; rs490460; rs522843; rs619360; rs680210; rs593245; rs497902; rs548381; rs681120; rs2445939; rs656083; rs573442; rs583161; rs477036; rs551662; rs676134; rs2510446; rs473210; rs609332; rs550319; rs2305822; rs17120560; rs507805; rs525493; rs11604395; rs574603; rs476469; rs17120581; rs528837; rs4245169; rs28989470; rs28989489; rs28917237; rs28917244; rs28989485; rs28989505; rs28917242; rs635367; rs28989484; rs28989494; rs28989501; rs28989481; rs486896; rs28917245; rs28917243; rs28989493; rs28989476; rs28989504; rs1271835; rs964779; rs28989500; rs28989488; rs28989473; rs28917236; rs28920768; rs28989486; rs28989492; rs558229; rs28917246; rs28989499; rs557985; rs17857093; rs1061659; rs28989503; rs11216349; rs12288248; rs28989509; rs34580925; rs28989510; rs28989508; rs28989515; rs34110772; rs28989507; rs11540911; rs34502557; rs28989512; rs35615085; rs28989513; rs11456029; rs28917247; rs28989472; rs35243058; rs7350483; rs3837419; rs520909; rs28989502; rs28917239; rs28989475; rs550835; rs34600928; rs28989495; rs28989480; rs35130396; rs35283919; rs12279606; rs12419997; rs12798410; rs11825386; rs34981011; rs28989468; rs12802397; rs1144037; rs35386843; rs28989496; rs34071288; rs28989491; rs28920168; rs531959; rs28989497; rs12279121; rs28989474; rs508758; rs28989483; rs35815120; rs550859; rs28989479; rs28989477; rs28989482; rs34135426; rs600314; rs12281824; rs479673; rs28989490; rs28917240; rs508675; rs3907097; rs1261743; rs486307; rs28917238; rs28989471; rs28989469; rs12292274; rs5795073; rs28989487; rs3214855; rs28989478; rs12291489; rs28989498; rs663166; rs594053; rs28917241; rs35955684; rs1048162; rs11601511; rs11820107; rs12282721; rs17584190; rs2305821; rs34687830; rs35360699; rs3741288; rs501179; rs505045; rs536817; rs555075; rs560564; rs623321; rs7083

# Macromolecular_Interacting_Partner_12_General_References:
10531052; 10591214; 10591213; 10656250; 11516562; 10677483; 11953458

# Macromolecular_Interacting_Partner_12_References:
17149856; 8562317

# Macromolecular_Interacting_Partner_13_ID:
8283

# Macromolecular_Interacting_Partner_13_Name:
Transforming growth factor beta-2 precursor

# Macromolecular_Interacting_Partner_13_Synonyms:
TGF-beta-2; Glioblastoma-derived T-cell suppressor factor; G-TSF; BSC-1 cell growth inhibitor; Polyergin; Cetermin

# Macromolecular_Interacting_Partner_13_Gene_Name:
TGFB2

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Transforming growth factor beta2 precursor
MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP
EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSENAIPP
TFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSP
TQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIP
NKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRK
KRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQH
SRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
414

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
47748

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
8.64

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
Function:  growth factor activity
Function:  signal transducer activity
Function:  receptor binding
Function:  transforming growth factor beta receptor binding
 ||
>>>
Process:  growth
Process:  cell growth
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF00019:TGF_beta;
PF00688:TGFb_propeptide

# Macromolecular_Interacting_Partner_13_Signals:
1-19

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
31960

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
TGFB2_HUMAN (P61812)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
TGFB2

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
TGFB2

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:11768

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>1245 bp
ATGCACTACTGTGTGCTGAGCGCTTTTCTGATCCTGCATCTGGTCACGGTCGCGCTCAGC
CTGTCTACCTGCAGCACACTCGATATGGACCAGTTCATGCGCAAGAGGATCGAGGCGATC
CGCGGGCAGATCCTGAGCAAGCTGAAGCTCACCAGTCCCCCAGAAGACTATCCTGAGCCC
GAGGAAGTCCCCCCGGAGGTGATTTCCATCTACAACAGCACCAGGGACTTGCTCCAGGAG
AAGGCGAGCCGGAGGGCGGCCGCCTGCGAGCGCGAGAGGAGCGACGAAGAGTACTACGCC
AAGGAGGTTTACAAAATAGACATGCCGCCCTTCTTCCCCTCCGAAAATGCCATCCCGCCC
ACTTTCTACAGACCCTACTTCAGAATTGTTCGATTTGACGTCTCAGCAATGGAGAAGAAT
GCTTCCAATTTGGTGAAAGCAGAGTTCAGAGTCTTTCGTTTGCAGAACCCAAAAGCCAGA
GTGCCTGAACAACGGATTGAGCTATATCAGATTCTCAAGTCCAAAGATTTAACATCTCCA
ACCCAGCGCTACATCGACAGCAAAGTTGTGAAAACAAGAGCAGAAGGCGAATGGCTCTCC
TTCGATGTAACTGATGCTGTTCATGAATGGCTTCACCATAAAGACAGGAACCTGGGATTT
AAAATAAGCTTACACTGTCCCTGCTGCACTTTTGTACCATCTAATAATTACATCATCCCA
AATAAAAGTGAAGAACTAGAAGCAAGATTTGCAGGTATTGATGGCACCTCCACATATACC
AGTGGTGATCAGAAAACTATAAAGTCCACTAGGAAAAAAAACAGTGGGAAGACCCCACAT
CTCCTGCTAATGTTATTGCCCTCCTACAGACTTGAGTCACAACAGACCAACCGGCGGAAG
AAGCGTGCTTTGGATGCGGCCTATTGCTTTAGAAATGTGCAGGATAATTGCTGCCTACGT
CCACTTTACATTGATTTCAAGAGGGATCTAGGGTGGAAATGGATACACGAACCCAAAGGG
TACAATGCCAACTTCTGTGCTGGAGCATGCCCGTATTTATGGAGTTCAGACACTCAGCAC
AGCAGGGTCCTGAGCTTATATAATACCATAAATCCAGAAGCATCTGCTTCTCCTTGCTGC
GTGTCCCAAGATTTAGAACCTCTAACCATTCTCTACTACATTGGCAAAACACCCAAGATT
GAACAGCTTTCTAATATGATTGTAAAGTCTTGCAAATGCAGCTAA

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
Y00083

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_13_Locus:
1q41

# Macromolecular_Interacting_Partner_13_SNPs:
rs10482810; rs900; rs11466412; rs1890994; rs947712; rs2796822; rs1539399; rs1891467; rs2799090; rs1890995; rs1797071; rs2796818; rs2796821; rs2009112; rs2796819; rs2796820; rs2796813; rs2027566; rs6665080; rs2799086; rs1417488; rs2000220; rs6678287; rs7531245; rs7536600; rs6662137; rs1418553; rs12029576; rs6671370; rs6658473; rs6703224; rs1418555; rs1342586; rs6684205; rs4846481; rs1418554; rs2799103; rs4846479; rs2798631; rs4846480; rs10482796; rs1934852; rs6604605; rs6688036; rs4625350; rs947711; rs6657275; rs4846478; rs6665174; rs3892225; rs10482795; rs7528564; rs2796814; rs2096038; rs10482751; rs2799083; rs10779329; rs10482792; rs13375763; rs10482772; rs10482759; rs4846267; rs7515588; rs12408756; rs10482821; rs10482735; rs10482741; rs10482727; rs12048049; rs10863396; rs11118103; rs2796815; rs10482812; rs10482817; rs10482750; rs2799085; rs11810236; rs10482745; rs12088448; rs10482791; rs2799091; rs17047714; rs10482838; rs10482819; rs17047715; rs4335431; rs10482824; rs10482807; rs7537047; rs9308385; rs6680004; rs10482833; rs1538926; rs11466372; rs10482758; rs7529920; rs6604609; rs10863398; rs6691619; rs11466399; rs10482827; rs12097734; rs10482752; rs2799095; rs7515763; rs12405805; rs10482766; rs10746379; rs1317681; rs11581605; rs12088579; rs12078397; rs12405215; rs11118094; rs11118097; rs11466383; rs2796812; rs10482761; rs2796825; rs10482743; rs17047703; rs7554934; rs12082184; rs11118088; rs11118090; rs2799102; rs10482816; rs4846266; rs10482826; rs6604607; rs10482780; rs10482822; rs10482728; rs10482836; rs12058490; rs11579807; rs11807048; rs11466406; rs11466379; rs10482835; rs10482799; rs12088605; rs10482764; rs11466370; rs10482742; rs17047759; rs11466397; rs11466386; rs10482754; rs10482813; rs10482779; rs10482830; rs2796823; rs11118099; rs6656048; rs11466381; rs10482801; rs10482786; rs10482808; rs7546632; rs11466401; rs2798628; rs17047744; rs17173695; rs6604610; rs11806833; rs12082759; rs17047711; rs10482834; rs12094199; rs17558745; rs6686287; rs11466371; rs10482829; rs7554528; rs10482793; rs11466376; rs11466405; rs7517802; rs10482730; rs10482765; rs10482771; rs4846476; rs11118098; rs12096466; rs12066658; rs12070060; rs17047756; rs10482798; rs7525821; rs17047719; rs11466389; rs10863394; rs6697137; rs10482775; rs6604608; rs10482777; rs10482825; rs2799097; rs6679372; rs10482820; rs17173696; rs10482809; rs17047723; rs6695493; rs17047804; rs11118102; rs11466400; rs10863397; rs7546539; rs10482740; rs12078363; rs11466392; rs6671843; rs10482823; rs11466384; rs17047682; rs10482789; rs11466404; rs17047729; rs10482788; rs6667585; rs10482803; rs10482736; rs10482757; rs17047707; rs10482744; rs10482837; rs11118091; rs12085618; rs2796817; rs12069974; rs10482814; rs17047726; rs2153573; rs10863395; rs2799084; rs11466373; rs10482774; rs2027567; rs10482748; rs7529990; rs6668651; rs10482739; rs10482729; rs11466388; rs7550053; rs13374308; rs7547457; rs2799096; rs10482755; rs11466409; rs17047740; rs12076065; rs11466391; rs7517761; rs11466398; rs17047721; rs10482787; rs10482802; rs12094284; rs10482781; rs10482832; rs11466374; rs10482800; rs12563811; rs12035819; rs10482769; rs12077374; rs11267093; rs10482831; rs11466395; rs10482732; rs11118089; rs10482731; rs12079125; rs12022831; rs2796824; rs17047769; rs10482762; rs1343538; rs11466382; rs10482811; rs7528501; rs991967; rs11557794; rs1021; rs11118100; rs34257415; rs11428926; rs10482794; rs11804415; rs1343537; rs34305588; rs35401357; rs11375587; rs34994454; rs34461501; rs11118095; rs34314809; rs10482738; rs10482784; rs28703602; rs35055029; rs12048582; rs11466408; rs35511163; rs35666134; rs36069968; rs7548011; rs28564283; rs34859854; rs34196637; rs12129220; rs11576241; rs12744698; rs11299363; rs10482776; rs11466375; rs10449302; rs11405199; rs11118104; rs10482778; rs10482768; rs35561400; rs35705960; rs34471604; rs12090312; rs10482746; rs6671174; rs10695360; rs10656513; rs36100067; rs11466394; rs12731071; rs36177895; rs11401661; rs11466385; rs4406707; rs5742078; rs35412418; rs10482737; rs12093477; rs10581735; rs12406538; rs12128032; rs11428925; rs12751880; rs10482804; rs11466410; rs34144155; rs35184821; rs35981664; rs28447199; rs10528827; rs35735707; rs10630101; rs2799094; rs11466396; rs12064442; rs6683154; rs4846268; rs2799089; rs10482749; rs10482734; rs12731614; rs35097289; rs10482726; rs4450076; rs12058971; rs11375487; rs1343536; rs35504165; rs6696495; rs7536358; rs11466380; rs10482785; rs10482818; rs35443205; rs34732124; rs34372197; rs12751696; rs34722473; rs12140367; rs5781033; rs35753251; rs34494703; rs11466393; rs11805848; rs28787047; rs12063836; rs12086266; rs11466411; rs5781034; rs35874672; rs35208504; rs12091932; rs6680000; rs10482815; rs28540714; rs34457023; rs35642714; rs6664146; rs10465673; rs12090824; rs11118093; rs35265019; rs10482782; rs10482770; rs12404109; rs35620006; rs34991790; rs11466377; rs17047808; rs34712442; rs34375134; rs6668477; rs11442285; rs35663827; rs36115084; rs35717741; rs35596608; rs10482797; rs2799088; rs34492420; rs34141354; rs17047736; rs34825461; rs11800054; rs6671080; rs12075542; rs10482828; rs10482753; rs10482790; rs10482806; rs10482733; rs11466378; rs36042627; rs6671985; rs10482763; rs11285412; rs34140547; rs34707217; rs10482773; rs12129111; rs12083371; rs12037898; rs13375381; rs11118101; rs10535892; rs35011398; rs34788470; rs10465672; rs12130689; rs34804099; rs36045624; rs35439774; rs12040998; rs34950123; rs35549409; rs10482747; rs4437933; rs5012300; rs28689770; rs11466403; rs12751683; rs10465671; rs11466402; rs10482756; rs35384454; rs11466387; rs35136815; rs34738702; rs10482767; rs35450089; rs6686687; rs11284588; rs11810299; rs10482805; rs35941091; rs11466407; rs11312252; rs12404108; rs35107200; rs11118096; rs10482760; rs2799087; rs1890993; rs4481918; rs41384648; rs10429950; rs1046017; rs10495098; rs1106569; rs11118108; rs12032375; rs12049094; rs12408711; rs1342588; rs1342590; rs1418556; rs1473526; rs1473527; rs1557153; rs17047863; rs17047869; rs17047871; rs2799098; rs3737977; rs3902857; rs4846482; rs6657698; rs6658835; rs6683598; rs6691070; rs6703073; rs6704255; rs7529798; rs885829; rs954014

# Macromolecular_Interacting_Partner_13_General_References:
3322813; 3162414; 2850146; 1764261; 3476488; 12706107; 1631557; 1641027; 11528528

# Macromolecular_Interacting_Partner_13_References:
1704799; 7507109; 9237639; 9780213

End of HMDB00164

Beginning of HMDB00167
# Accession_No:
HMDB00167

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-19 13:22:07

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
L-Threonine

# Description:
Threonine is an essential amino acid in humans. It is abundant in human plasma, particularly in newborns. Severe deficiency of threonine causes neurological dysfunction and lameness in experimental animals.  Threonine is an immunostimulant which promotes the growth of thymus gland. It also can probably promote cell immune defense function. This amino acid has been useful in the treatment of genetic spasticity disorders and multiple sclerosis at a dose of 1 gram daily. It is highly concentrated in meat products, cottage cheese and wheat germ. (http://www.dcnutrition.com/AminoAcids/) The threonine content of most of the infant formulas currently on the market is approximately 20% higher than the threonine concentration in human milk. Due to this high threonine content the plasma threonine concentrations are up to twice as high in premature infants fed these formulas than in infants fed human milk. The whey proteins which are used for infant formulas are sweet whey proteins. Sweet whey results from cheese production. Threonine catabolism in mammals appears to be due primarily (70-80%) to the activity of threonine dehydrogenase (EC 1.1.1.103) that oxidizes threonine to 2-amino-3-oxobutyrate, which forms glycine and acetyl CoA, whereas threonine dehydratase (EC 4.2.1.16) that catabolizes threonine into 2-oxobutyrate and ammonia, is significantly less active. Increasing the threonine plasma concentrations leads to accumulation of threonine and glycine in the brain. Such accumulation affects the neurotransmitter balance which may have consequences for the brain development during early postnatal life. Thus, excessive threonine intake during infant feeding should be avoided. (PMID 9853925)

# Synonyms:
(2S,3R)-(-)-Threonine; (2S,3R)-2-Amino-3-hydroxybutyrate; (2S,3R)-2-Amino-3-hydroxybutyric acid; (R-(R*,S*))-2-Amino-3-hydroxybutanoate; (R-(R*,S*))-2-Amino-3-hydroxybutanoic acid; (S)-Threonine; 2-Amino-3-hydroxybutanoate; 2-Amino-3-hydroxybutanoic acid; 2-Amino-3-hydroxybutyrate; 2-Amino-3-hydroxybutyric acid; L-(-)-Threonine; L-2-Amino-3-hydroxybutyrate; L-2-Amino-3-hydroxybutyric acid; L-alpha-Amino-beta-hydroxybutyrate; L-alpha-Amino-beta-hydroxybutyric acid; Thr; Threonin; Threonine; [R-(R*,S*)]-2-Amino-3-hydroxybutanoate; [R-(R*,S*)]-2-Amino-3-hydroxybutanoic acid; [R-(R*,S*)]-2-amino-3-hydroxy-Butanoate; [R-(R*,S*)]-2-amino-3-hydroxy-Butanoic acid

# Chemical_IUPAC_Name:
2-amino-3-hydroxy-butanoic acid

# Chemical_Formula:
C4H9NO3

# Chemical_Structure:
tbl_chemical:::HMDB00167_ZOOM.png:::119283229893942138

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00167_THUMB.png:::119283229735589438

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids; Nitrogenous Compounds

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
secondary alcohol; 1,2-aminoalcohol; primary amine; primary aliphatic amine (alkylamine); carboxylic acid; alpha-aminoacid

# Taxonomy_Biofunction:
Essential amino acids; Component of Aminoacyl-tRNA biosynthesis; Component of Glycine, serine and threonine metabolism

# Taxonomy_Source:
Exogenous

# Molecular_Weight:
119.05824

# Molecular_Weight_Avg:
119.11916

# Smiles_String_isomeric:
C[C@@H](O)[C@H](N)C(O)=O

# Smiles_String_canonical:
CC(O)C(N)C(O)=O

# KEGG_Compound_ID:
C00188

# BioCyc_ID:
THR

# PubChem_CID:
6288

# PubChem_SID:
841559; 828546; 838580; 3134685; 3488; 743006; 7890772; 10533896; 8143617; 824404; 8138261; 828065; 7847109; 149226; 8153965

# OMIM_ID:
273770

# Metagene_ID:
Not Available

# BiGG_ID:
34186

# Wikipedia_ID:
L-Threonine

# METLIN_ID:
32

# Ref_ID:
7139629; 15911239; 1141232; 12297216; 14992292; 7729054; 15867923; 15855168; 15851471; 12097436; 15864413; 1246600; 6696735; 15875219; 6198473

# ChEBI_ID:
16857

# CAS_Registry_Number:
72-19-5

# InChI:
InChI=1/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1

# Synthesis_Reference:
L-Threonine fermentation.  I.  Microbial conversion of L-homoserine to L-threonine.     Fujita, Chuzo; Nara, Takashi; Samejima, Hirotoshi; Kinoshita, Shukuo.    Kyowa Hakko Kogyo Co., Ltd.,  Tokyo,  Japan.    Nippon Nogei Kagaku Kaishi  (1965),  39(6),  2

# Melting_Point:
256 oC

# Melting_Point_predicted:
34.4 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
97.0 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
477.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-2.94 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-3.00 [Predicted by ALOGPS]; -3.5 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::L-Threonine.pdf:::1132562210013105801

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::L-Threonine.mol:::1132723811546959548

# SDF_File_[Text]:
tbl_chemical:::HMDB00167.sdf:::11928322943022537

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00167.pdb:::119283229598081669

# PDB_ID:
1EVK

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041023_P00_04_BA_1DP_PRESAT_expanded_2.gif:::114168236334222509

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041023_P00_04_BA_1DP_presat.zip:::1177710619024907057

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041023_P00_04_BA_1DP_Assigned.png:::114667712264838037

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::041023_P00_04_BA_1DC_29.jpg:::114168459839979642

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041023_P00_04_BA_1DC_29.zip:::114168459836971523

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041023_P00_04_BA_1DC_29_Assigned.jpg:::114332840916595189

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041023_P00_04_BA_2DHSQC_31.jpg:::114616633006645088

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041023_P00_04_BA_2DHSQC_31.zip:::114616633007365248

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041023_P00_04_BA_2DHSQC_31_Assigned.jpg:::116172409757268270

# Predicted_H_NMR_Spectrum:
tbl_chemical:::L-Threonine.gif:::1132732116968751460

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00167_peaks.txt:::1156309591756565609

# Predicted_C_NMR_Spectrum:
tbl_chemical:::L-Threonine_C.gif:::1132737708450151434

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00167_peaks.txt:::1156310781301243792

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00167L.png:::117555262951111789; Medium Energy:tbl_ms:::HMDB00167M.png:::117555268264938984; High Energy:tbl_ms:::HMDB00167H.png:::117555271617936105

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000049.png:::116890824556254208

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000049.txt:::116890824556229096

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000049.png:::116890824529675811

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000049.txt:::11689082455462962

# Cellular_Location:
Cytoplasm; Extracellular

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Urine	12.7 (4.934-20.4)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Blood	140.0 (107.0-173.0)	umol/L	Adult:>18_yrs_old	Both	Normal	12297216
Blood	215.0 +/- 60.0	umol/L	Newborn:0-30_days_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	140.0 +/- 28.0	umol/L	Children:1-13_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	146.0 +/- 22.0	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	154.0 +/- 40.0	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	32.0 (4.00-60.0)	umol/L	Adult:>18_yrs_old	Both	Normal	7729054
Cerebrospinal_Fluid(CSF)	27.7 +/- 4.7	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	45.9 +/- 12.3	umol/L	Adult:>18_yrs_old	N/A	Normal	15911239
Cerebrospinal_Fluid(CSF)	37.4 +/- 7.6	umol/L	Adult:>18_yrs_old	N/A	Normal	6198473
Cerebrospinal_Fluid(CSF)	34.7 +/- 6.2	umol/L	Adult:>18_yrs_old	N/A	Normal	6198473
Saliva	>10	umol/L	Adult:>18_yrs_old	Both	Normal	12097436


# Concentration_[Abnormal]:
Blood	90.0	umol/L	Adult:>18_yrs_old	Both	Diabetes	6696735
Blood	114.0 (105.0-123.0)	umol/L	Adult:>18_yrs_old	Both	Acute seizures	14992292
Blood	118.0 (114.0-122.0)	umol/L	Adult:>18_yrs_old	Both	Refractory localization-related epilepsy (RLE)	14992292
Cerebrospinal_Fluid(CSF)	41.0 +/- 15.9	umol/L	N/A	N/A	Leukemia	15911239
Cerebrospinal_Fluid(CSF)	30.2 +/- 9.8	umol/L	N/A	N/A	Leukemia with CNS disease	15911239


# Associated_Disorders:
Acute seizures; Axillary Metastases; Diabetes; Kidney Damage; Leukemia; Leukemia with CNS disease; Refractory Localization-Related Epilepsy (RLE)

# Pathway_Names:
Not Available

# Pathway_Images:
Not Available

# KEGG_Images:
Not Available

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5853

# Metabolic_Enzyme_1_Name:
Threonyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_1_Synonyms:
Threonine--tRNA ligase; ThrRS

# Metabolic_Enzyme_1_Gene_Name:
TARS

# Metabolic_Enzyme_1_Protein_Sequence:
>ThreonyltRNA synthetase, cytoplasmic
MFEEKASSPSGKMGGEEKPIGAGEEKQKEGGKKKNKEGSGDGGRAELNPWPEYIYTRLEM
YNILKAEHDSILAEKAEKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVIA
KVNNVVWDLDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIE
NGFYYDMYLEEGGVSSNDFSSLEALCKKIIKEKQAFERLEVKKETLLAMFKYNKFKCRIL
NEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKALKIHKNSSTYWEGKADMETLQRIYGI
SFPDPKMLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFI
RSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMF
DHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCL
DFLRTVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFY
GPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERM
IAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNK
KIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAE
EEF

# Metabolic_Enzyme_1_Number_of_Residues:
723

# Metabolic_Enzyme_1_Molecular_Weight:
83436

# Metabolic_Enzyme_1_Theoretical_pI:
6.64

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  threonine-tRNA ligase activity
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  transporter activity
Function:  electron transporter activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  threonyl-tRNA aminoacylation
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  protein biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_1_Specific_Function:
ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)

# Metabolic_Enzyme_1_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_1_Reaction:
ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF03129:HGTP_anticodon;
PF02824:TGS;
PF00587:tRNA-synt_2b;
PF07973:tRNA_SAD

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 6.1.1.3

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1464742

# Metabolic_Enzyme_1_SwissProt_ID:
SYTC_HUMAN (P26639)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
TARS

# Metabolic_Enzyme_1_Geneatlas_id:
TARS

# Metabolic_Enzyme_1_hgnc_id:
HGNC:11572

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>2139 bp
ATGGGAGGCGAGGAGAAGCCGATTGGTGCTGGTGAAGAGAAGCAAAAGGAAGGAGGCAAA
AAGAAGAACAAAGAAGGATCTGGAGATGGAGGTCGAGCTGAGTTGAATCCTTGGCCTGAA
TATATTTACACACGTCTTGAGATGTATAATATACTAAAAGCAGAACATGATTCCATTCTG
GCAGAAAAGGCAGAAAAAGATAGCAAGCCAATTAAAGTCACTTTGCCTGATGGTAAACAG
GTTGATGCGGAATCTTGGAAAACTACACCATATCAAATTGCCTGTGGAATTAGTCAAGGC
CTGGCCGACAACACCGTTATTGCTAAAGTAAATAATGTTGTGTGGGACCTGGACCGCCCT
CTGGAAGAAGATTGTACCTTGGAGCTTCTCAAGTTTGAGGATGAGGAAGCTCAGGCAGTG
TATTGGCACTCTAGTGCTCACATAATGGGTGAAGGCATGGAAAGAGTCTATGGTGGATGT
TTATGCTACGGTCCGCCAATAGAAAATGGATTCTATTATGACATGTACCTCGAAGAAGGG
GGTGTGTCTAGCAATGATTTCTCTTCTCTGGAGGCTTTGTGTAAGAAAATCATTAAAGAA
AAACAAGCTTTTGAAAGACTGGAAGTTAAGAAAGAAACTTTACTGGCAATGTTTAAGTAC
AACAAGTTCAAATGCCGGATATTGAATGAAAAGGTGAATACTCCAACTACCACAGTCTAT
AGATGTGGCCCTTTGATAGATCTCTGCCGGGGTCCTCATGTTAGACACACGGGCAAAATT
AAGGCTTTAAAAATACACAAAAATTCCTCCACGTACTGGGAAGGCAAAGCAGATATGGAG
ACTCTCCAGAGAATTTATGGCATTTCATTCCCAGATCCTAAAATGTTGAAAGAGTGGGAG
AAGTTCCAAGAGGAAGCTAAAAACCGAGATCATAGGAAAATTGGCAGGGACCAAGAACTA
TATTTCTTTCATGAACTCAGCCCTGGAAGTTGCTTTTTTCTGCCAAAAGGAGTCTATATT
TATAATGCACTTATTGAATTCATTAGGAGCGAATATAGGAAAAGAGGATTCCAGGAGGTA
GTCACCCCAAACATCTTCAACAGCCGACTCTGGATGACCTCGGGCCACTGGCAGCACTAC
AGCGAGAACATGTTCTCCTTTGAGGTGGAGAAGGAGCTGTTTGCCCTGAAACCCATGAAC
TGCCCAGGACACTCCCTTATGTTTGATCATCGGCCAAGGTCCTGGCGAGAACTGCCTCTG
CGGCTAGCTGATTTTGGGGGTCTTCATAGGAACGAGCTGTCTGGAGCACTCACAGGACTC
ACCCGGGTACGAAGATTCCAACAGGATGATGCTCACATATTCTGTGCCATGGAGCAGATT
GAAGATGAAATAAAAGGTTGTTTGGATTTTCTACGTACGGTATATAGCGTATTTGGATTT
TCTTTTAAACTAAACCTTTCTACTCGCCCGGAAAAATTCCTTGGAGATATCGAAGTATGG
GATCAAGCTGAGAAACAACTTGAAAACAGTCTGAATGAATTTGGTGAAAAGTGGGAGTTA
AACTCTGGAGATGGAGCTTTCTATGGCCCAAAGATTGACATACAGATTAAAGATGCGATT
GGGCGGTACCACCAGTGTGCAACCATCCAGCTGGATTTCCAGTTGCCCATCAGATTTAAT
CTTACTTATGTAAGCCATGATGGTGAGGATAAGAAAAGGCCAGTGATTGTTCATCGAGCC
ATCTTGGGATCAGTGGAAAGAATGATTGCTATCCTCACAGAAAACTATGGGGGCAAATTG
GCCCCCTTTTGGCTGTCCCCTCGCCAGGTAATGGTAGTTCCAGTGGGACCAACCTGTGAT
GAATATGCCCAAAACGTACGACAACAATTCCACGATGCCAAATTCATGGCAGACATTGAT
CTGGATCCAGGCTGTACATTGAATAAAAAGATTCGAAATGCACAGTTAGCACAGTATAAC
TTCATTTTAGTTGTTGGTGAAAAAGAGAAAATCACTGGCACTGTTAATATCCGCACAAGA
GACAATAAGGTCCACGGGGAACGCACCATTTCTGAAACTATCGAGCGGCTACAGCAGCTC
AAAGAGTTCCGCAGCAAACAGGCAGAAGAAGAATTTTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M63180

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_1_Locus:
5p13.2

# Metabolic_Enzyme_1_SNPs:
rs16891129; rs34334786; rs2270902; rs3736393; rs2270905; rs7261; rs2304621; rs28362597; rs3765145; rs1003000; rs6450990; rs893551; rs2292015; rs3849682; rs3777083; rs3777081; rs3777079; rs7705177; rs6887261; rs6884566; rs3765146; rs2270903; rs3777077; rs3777076; rs3777082; rs6893613; rs16891189; rs10941055; rs9686398; rs12659798; rs6450991; rs3777075; rs11955272; rs11955289; rs3777074; rs3849683; rs3765144; rs3765147; rs3777078; rs6885094; rs12522185; rs6866808; rs16891141; rs6880623; rs3830415; rs12517884; rs4867513; rs4421109; rs3215116; rs6880616; rs16891180; rs2270904; rs4867512; rs16891143; rs2292014; rs3777073; rs7734078; rs12520517; rs3756661; rs3756664; rs3756663; rs3756662; rs6870521; rs11742862; rs16891125; rs1804513; rs1051213; rs11541416; rs1051210; rs1131566; rs1051211; rs34715628; rs16891192; rs34673293; rs33932086; rs17565038; rs12187755; rs5867191; rs35931457; rs5022546; rs10583985; rs11356243; rs12187715; rs2642668; rs34875186; rs28475744; rs3842066; rs35121278; rs34630295; rs9885230; rs12187727; rs12188515; rs35817175; rs11747025; rs11457738; rs13154531; rs4267874; rs34910729; rs34725061; rs4398642; rs1687511; rs2642669; rs35375523; rs13184927; rs34596299; rs11952399; rs3777080; rs11414360; rs11383852; rs11422595; rs13164529; rs11960553; rs34580645; rs34374932; rs17455135; rs5867190; rs35331115; rs35079782; rs5867189; rs2453288; rs2164991; rs6889780; rs36102914; rs35558849; rs1080; rs11950608; rs12054982; rs12514530; rs1438728; rs1542031; rs1542998; rs16891198; rs16891202; rs4867143; rs6885517; rs7702124; rs925210

# Metabolic_Enzyme_1_General_References:
2033077

# Metabolic_Enzyme_1_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8479

# Macromolecular_Interacting_Partner_1_Name:
Asc-type amino acid transporter 1

# Macromolecular_Interacting_Partner_1_Synonyms:
Asc-1

# Macromolecular_Interacting_Partner_1_Gene_Name:
SLC7A10

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Asctype amino acid transporter 1
MAGHTQQPSGRGNPRPAPSPSPVPGTVPGASERVALKKEIGLLSACTIIIGNIIGSGIFI
SPKGVLEHSGSVGLALFVWVLGGGVTALGSLCYAELGVAIPKSGGDYAYVTEIFGGLAGF
LLLWSAVLIMYPTSLAVISMTFSNYVLQPVFPNCIPPTTASRVLSMACLMLLTWVNSSSV
RWATRIQDMFTGGKLLALSLIIGVGLLQIFQGHFEELRPSNAFAFWMTPSVGHLALAFLQ
GSFAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELLSSN
AVAVTFGEKLLGYFSWVMPVSVALSTFGGINGYLFTYSRLCFSGAREGHLPSLLAMIHVR
HCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLLLRWRRPALHRPI
KVNLLIPVAYLVFWAFLLVFSFISEPMVCGVGVIIILTGVPIFFLGVFWRSKPKCVHRLT
ESMTHWGQELCFVVYPQDAPEEEENGPCPPSLLPATDKPSKPQ

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
523

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
56799

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
8.24

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
 Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_1_Specific_Function:
Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_1_Signals:
1-136

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
40-60
72-92
113-133
268-288
310-330
362-382
388-408
424-444
448-468

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
9309293

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
AAA1_HUMAN (Q9NS82)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
SLC7A10

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
SLC7A10

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:11058

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; multi-pass membrane protein (Probable)

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1572 bp
ATGGCCGGCCACACGCAGCAGCCGAGCGGGCGCGGGAACCCCAGGCCTGCGCCCTCGCCC
TCCCCAGTCCCAGGGACCGTCCCCGGCGCCTCGGAGCGGGTGGCGCTCAAGAAGGAGATC
GGGCTGCTGAGCGCCTGCACCATCATCATCGGGAACATCATCGGCTCGGGCATCTTCATC
TCGCCCAAGGGGGTCCTGGAGCACTCAGGCTCCGTGGGTCTGGCCCTGTTCGTCTGGGTC
CTGGGTGGGGGCGTGACGGCTCTGGGCTCCCTCTGCTATGCAGAGCTGGGAGTCGCCATC
CCCAAGTCTGGCGGGGACTACGCCTACGTCACAGAGATCTTCGGGGGCCTGGCTGGCTTT
CTGCTGCTCTGGAGCGCCGTCCTCATCATGTACCCCACCAGCCTTGCTGTCATCTCCATG
ACCTTCTCCAACTACGTGCTGCAGCCCGTGTTCCCCAACTGCATCCCCCCCACCACAGCC
TCCCGGGTGCTGTCCATGGCCTGCCTGATGCTCCTGACATGGGTGAACAGCTCCAGTGTG
CGCTGGGCCACGCGCATCCAGGACATGTTCACAGGCGGGAAGCTGCTGGCCTTGTCCCTC
ATCATCGGCGTGGGCCTTCTCCAGATCTTCCAAGGACACTTCGAGGAGCTGAGGCCCAGC
AATGCCTTTGCTTTCTGGATGACGCCCTCCGTGGGACACCTGGCCCTGGCCTTCCTCCAG
GGCTCCTTCGCCTTCAGTGGCTGGAACTTCCTCAACTATGTCACCGAGGAGATGGTTGAC
GCCCGAAAGAACCTACCTCGCGCCATCTTCATCTCCATCCCACTGGTGACCTTCGTGTAC
ACGTTCACCAACATTGCCTACTTCACGGCCATGTCCCCCCAGGAGCTGCTCTCCTCCAAT
GCGGTGGCTGTGACCTTCGGGGAGAAGCTGCTGGGCTACTTTTCTTGGGTCATGCCTGTC
TCCGTGGCTCTGTCAACCTTCGGAGGGATCAATGGTTACCTGTTCACCTACTCCAGGCTG
TGCTTCTCTGGAGCCCGCGAGGGGCACCTGCCCAGCCTGCTGGCCATGATCCACGTCAGA
CACTGCACCCCCATCCCCGCCCTCCTCGTCTGTTGCGGGGCCACAGCCGTCATCATGCTC
GTGGGCGACACGTACACGCTCATCAACTATGTGTCCTTCATCAACTACCTCTGCTACGGC
GTCACCATCCTGGGCCTGCTGCTGCTGCGCTGGAGGCGGCCTGCACTCCACAGGCCCATC
AAGGTGAACCTTCTCATCCCCGTGGCGTACTTGGTCTTCTGGGCCTTCCTGCTGGTCTTC
AGCTTCATCTCAGAGCCTATGGTCTGTGGGGTCGGCGTCATCATCATCCTTACGGGGGTG
CCCATTTTCTTTCTGGGAGTGTTCTGGAGAAGCAAACCAAAGTGTGTGCACAGACTCACA
GAGTCCATGACACACTGGGGCCAGGAGCTGTGTTTCGTGGTCTACCCCCAGGACGCCCCC
GAAGAGGAGGAGAATGGCCCCTGCCCACCCTCCCTGCTGCCTGCCACAGACAAGCCCTCG
AAGCCACAATGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AB037670

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_1_Locus:
19q13.1

# Macromolecular_Interacting_Partner_1_SNPs:
rs34663170; rs2303094; rs4805031; rs7258412; rs12609177; rs8106493; rs1974807; rs10406787; rs8101891; rs7254894; rs12609763; rs7508758; rs3786926; rs2303093; rs8106375; rs4407170; rs3786927; rs2241378; rs8105889; rs11669156; rs1009175; rs11673535; rs16967863; rs11671790; rs34454261; rs8105887; rs12972369; rs11084715; rs4805030; rs4516343; rs8110876; rs35557280; rs16967861; rs12972468; rs11878801; rs11666788; rs10417375; rs726822; rs1465424; rs4330029; rs4553741; rs7251684; rs889102; rs7249980; rs35390810; rs11542481; rs34961684; rs8107888; rs12151336; rs11670702; rs34937345; rs34203180; rs889101; rs34180473; rs10555903; rs12982023; rs33951856; rs4805862; rs11882613; rs11879325; rs34981363; rs11378328; rs8107002; rs11880750; rs34309383; rs5827838; rs35763570; rs35887187; rs7248380; rs34843019; rs11455629; rs28419758; rs35055563; rs35775570; rs35756066; rs11671925; rs34257327; rs10667670; rs34645339; rs36212687; rs3064210; rs5827839; rs11448774; rs5827841; rs3064187; rs5827842; rs889103; rs36216474; rs10410558; rs10412342; rs1056034; rs1056041; rs1107920; rs1107921; rs11084712; rs11666900; rs11671345; rs11672303; rs11673115; rs1559182; rs17694094; rs17760699; rs17848212; rs1862464; rs2112800; rs2194169; rs2303095; rs2303096; rs34138351; rs34158692; rs34529542; rs35831673; rs36029918; rs3745974; rs3745975; rs3745976; rs3745977; rs3745978; rs4444444; rs4805863; rs7359893; rs8100642; rs875550

# Macromolecular_Interacting_Partner_1_General_References:
10863037; 11509015

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8594

# Macromolecular_Interacting_Partner_2_Name:
SLC38A2 protein

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
SLC38A2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>SLC38A2 protein
MKQNLILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIG
AMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGY
TSGLSLLCMVFFLIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDS
CRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYL
LAALFGYLTFYEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTH
LLCASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIK
LVKKEPMKSVQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
406

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
45180

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
8.88

# Macromolecular_Interacting_Partner_2_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_2_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_2_Signals:
1-18

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
5-23; 48-69; 89-111; 115-137; 230-252; 272-294; 315-334; 339-361; 373-395

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
Q6IA88_HUMAN (Q6IA88)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
SLC38A2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
SLC38A2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:13448

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
CR457267

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_2_Locus:
12q

# Macromolecular_Interacting_Partner_2_SNPs:
rs10880961; rs7968283; rs956910; rs2897968; rs7968173; rs7961994; rs10880959; rs2307063; rs1873793; rs3742061; rs2307061; rs10880960; rs3782904; rs7965930; rs2307062; rs2279559; rs7974529; rs7960147; rs10785624; rs11183450; rs34139863; rs36065261; rs36022751; rs11340856; rs7966787; rs11313787; rs5797976; rs1046296; rs11183449; rs12307969; rs2307060; rs36019260; rs3837525; rs35534621; rs11183447; rs3832874; rs3830356; rs34489723; rs36066221; rs11298796; rs7295472; rs35732850; rs35944767; rs34099989; rs10880962; rs11183446; rs12368989; rs1492896; rs17096884; rs4768697; rs4768698; rs7135630; rs7967840; rs7975820; rs7979418

# Macromolecular_Interacting_Partner_2_General_References:
Not Available

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8627

# Macromolecular_Interacting_Partner_3_Name:
4F2 cell-surface antigen heavy chain

# Macromolecular_Interacting_Partner_3_Synonyms:
4F2hc; Lymphocyte activation antigen 4F2 large subunit; 4F2 heavy chain antigen; CD98 antigen

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC3A2

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>4F2 cellsurface antigen heavy chain
MSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKF
TGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHT
GALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQID
PNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAG
VDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLT
SSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLP
GTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLS
LFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQAS
DLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYAA

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
529

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
57945

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
4.99

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  amylase activity
Function:  alpha-amylase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_3_Specific_Function:
Involved in sodium-independent, high-affinity transport of large neutral amino acids. Required for normal and neoplastic cell growth

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00128:Alpha-amylase

# Macromolecular_Interacting_Partner_3_Signals:
1-98

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
82-104

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
182865

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
4F2_HUMAN (P08195)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC3A2

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC3A2

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:11026

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1590 bp
ATGAGCCAGGACACCGAGGTGGATATGAAGGAGGTGGAGCTGAATGAGTTAGAGCCCGAG
AAGCAGCCGATGAACGCGGCGTCTGGGGCGGCCATGTCCCTGGCGGGAGCCGAGAAGAAT
GGTCTGGTGAAGATCAAGGTGGCGGAAGACGAGGCGGAGGCGGCAGCCGCGGCTAAGTTC
ACGGGCCTGTCCAAGGAGGAGCTGCTGAAGGTGGCAGGCAGCCCCGGCTGGGTACGCACC
CGCTGGGCACTGCTGCTGCTCTTCTGGCTCGGCTGGCTCGGCATGCTTGCTGGTGCCGTG
GTCATAATCGTGCGAGCGCCGCGTTGTCGCGAGCTACCGGCGCAGAAGTGGTGGCACACG
GGCGCCCTCTACCGCATCGGCGACCTTCAGGCCTTCCAGGGCCACGGCGCGGGCAACCTG
GCGGGTCTGAAGGGGCGTCTCGATTACCTGAGCTCTCTGAAGGTGAAGGGCCTTGTGCTG
GGTCCAATTCACAAGAACCAGAAGGATGATGTCGCTCAGACTGACTTGCTGCAGATCGAC
CCCAATTTTGGCTCCAAGGAAGATTTTGACAGTCTCTTGCAATCGGCTAAAAAAAAGAGC
ATCCGTGTCATTCTGGACCTTACTCCCAACTACCGGGGTGAGAACTCGTGGTTCTCCACT
CAGGTTGACACTGTGGCCACCAAGGTGAAGGATGCTCTGGAGTTTTGGCTGCAAGCTGGC
GTGGATGGGTTCCAGGTTCGGGACATAGAGAATCTGAAGGATGCATCCTCATTCTTGGCT
GAGTGGCAAAATATCACCAAGGGCTTCAGTGAAGACAGGCTCTTGATTGCGGGGACTAAC
TCCTCCGACCTTCAGCAGATCCTGAGCCTACTCGAATCCAACAAAGACTTGCTGTTGACT
AGCTCATACCTGTCTGATTCTGGTTCTACTGGGGAGCATACAAAATCCCTAGTCACACAG
TATTTGAATGCCACTGGCAATCGCTGGTGCAGCTGGAGTTTGTCTCAGGCAAGGCTCCTG
ACTTCCTTCTTGCCGGCTCAACTTCTCCGACTCTACCAGCTGATGCTCTTCACCCTGCCA
GGGACCCCTGTTTTCAGCTACGGGGATGAGATTGGCCTGGATGCAGCTGCCCTTCCTGGA
CAGCCTATGGAGGCTCCAGTCATGCTGTGGGATGAGTCCAGCTTCCCTGACATCCCAGGG
GCTGTAAGTGCCAACATGACTGTGAAGGGCCAGAGTGAAGACCCTGGCTCCCTCCTTTCC
TTGTTCCGGCGGCTGAGTGACCAGCGGAGTAAGGAGCGCTCCCTACTGCATGGGGACTTC
CACGCGTTCTCCGCTGGGCCTGGACTCTTCTCCTATATCCGCCACTGGGACCAGAATGAG
CGTTTTCTGGTAGTGCTTAACTTTGGGGATGTGGGCCTCTCGGCTGGACTGCAGGCCTCC
GACCTGCCTGCCAGCGCCAGCCTCCCAGCCAAGGCTGACCTCCTGCTCAGCACCCAGCCA
GGCCGTGAGGAGGGCTCCCCTCTTGAGCTGGAACGCCTGAAACTGGAGCCTCACGAAGGG
CTGCTGCTCCGCTTCCCCTACGCGGCCTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
J02939

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11q13

# Macromolecular_Interacting_Partner_3_SNPs:
rs4726; rs6932; rs489381; rs10897300; rs10897301; rs10792362; rs3809075; rs12221878; rs481235; rs12577251; rs4567465; rs12794763; rs7104190; rs507101; rs7106901; rs12098955; rs561385; rs519473; rs12804553; rs12274689; rs7935096; rs2070870; rs2920155; rs2282477; rs1140538; rs7944051; rs3015957; rs11548759; rs1051342; rs11548756; rs1051289; rs1051290; rs1802910; rs1051237; rs1802911; rs11548760; rs1051285; rs12272749; rs35228448; rs540791; rs549706; rs11231260; rs543622; rs541444; rs34047097; rs35246991; rs1815840; rs3840765; rs11231257; rs544453; rs35881347; rs35320203; rs2957168; rs7130029; rs519425; rs541388; rs34176851; rs535854; rs35091612; rs7106895; rs2096559; rs473815; rs11318751; rs5792273; rs12797676; rs499294; rs34225665; rs3809074; rs2957166; rs7115838; rs12803557; rs521939; rs1938675; rs563394; rs1300138; rs12225962; rs2105515; rs36034735; rs486306; rs12788771; rs1212628; rs1286159; rs5792274; rs12794229; rs7117639; rs495776; rs11231259; rs12366036; rs509327; rs35657900; rs11231261; rs496788; rs35988334; rs12788770; rs34335071; rs1298673; rs766316; rs34722625; rs560603; rs11824602; rs565303; rs34494671; rs35455481; rs7101685; rs1286160; rs510307; rs12270563; rs11231254; rs11231262; rs11318752; rs549635; rs12270604; rs2957167; rs11317361; rs7126772; rs34436839; rs11341257; rs577134; rs11558674; rs1059292; rs11231249; rs11231250; rs12270342; rs12295052; rs1785940; rs2071036; rs2269353; rs2507820; rs2509678; rs2510083; rs3737388; rs3737389; rs4034; rs480730; rs493851; rs498751; rs524891; rs547248; rs560006

# Macromolecular_Interacting_Partner_3_General_References:
3476959; 3036867; 3480538; 3265470; 12754519; 11840567; 12270127

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8650

# Macromolecular_Interacting_Partner_4_Name:
Neutral amino acid transporter A

# Macromolecular_Interacting_Partner_4_Synonyms:
SATT; Solute carrier family 1 member 4; Alanine/serine/cysteine/ threonine transporter; ASCT1

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC1A4

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Neutral amino acid transporter 
AMEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLG
AALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVA
YFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLF
PSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKK
LGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIF
ASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEEN
NGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVG
AAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQ
KATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
532

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
55724

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.18

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
 Function:  transporter activity
Function:  organic acid transporter activity
Function:  carboxylic acid transporter activity
Function:  dicarboxylic acid transporter activity
Function:  sodium:dicarboxylate symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  organic acid transport
Process:  carboxylic acid transport
Process:  dicarboxylic acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_4_Specific_Function:
Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00375:SDF

# Macromolecular_Interacting_Partner_4_Signals:
1-104

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
42-62
88-108
119-139
217-237
257-277
298-318
328-348
373-393
418-438

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
348012

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
SATT_HUMAN (P43007)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC1A4

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC1A4

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:10942

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane; multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1599 bp
ATGGAGAAGAGCAACGAGACCAACGGCTACCTTGACAGCGCTCAGGCGGGGCCTGCGGCC
GGGCCCGGAGCTCCGGGGACCGCGGCGGGACGCGCACGGCGTTGCGCGCGCTTCCTGCGG
CGCCAAGCGCTGGTGCTGCTCACCGTGTCCGGGGTGCTGGCGGGCGCGGGCCTGGGCGCG
GCGTTGCGCGGGCTCAGCCTGAGCCGCACGCAGGTCACCTACCTGGCCTTCCCCGGCGAG
ATGCTGCTCCGCATGCTGCGCATGATCATCCTGCCGCTGGTGGTCTGCAGCCTGGTGTCG
GGCGCCGCCTCGCTCGATGCCAGCTGCCTCGGGCGTCTGGGCGGCATCCGTGTCGCCTAC
TTTGGCCTCACCACACTGAGTGCCTCGGCGCTCGCCGTGGCCTTGGCGTTCATCATCAAG
CCAGGATCCGGTGCGCAGACCCTTCAGTCCAGCGACCTGGGGCTGGAGGACTCGGGGCCT
CCTCCTGTCCCCAAAGAGACGGTGGACTCTTTCCTCGACCTGGCCAGAAACCTGTTTCCC
TCCAATCTTGTGGTTGCAGCTTTCCGTACGTATGCAACCGATTATAAAGTCGTGACCCAG
AACAGCAGCTCTGGAAATGTAACCCATGAAAAGATCCCCATAGGCACTGAGATAGAAGGG
ATGAACATTTTAGGATTGGTCCTGTTTGCTCTGGTGTTAGGAGTGGCCTTAAAGAAACTA
GGCTCCGAAGGAGAAGACCTCATCCGTTTCTTCAATTCCCTCAACGAGGCGACGATGGTG
CTGGTGTCCTGGATTATGTGGTACGTACCTGTGGGCATCATGTTCCTTGTTGGAAGCAAG
ATCGTGGAAATGAAAGACATCATCGTGCTGGTGACCAGCCTGGGGAAATACATCTTCGCA
TCTATATTGGGCCATGTTATTCATGGAGGAATTGTTCTGCCACTTATTTATTTTGTTTTC
ACACGAAAAAACCCATTCAGATTCCTCCTGGGCCTCCTCGCCCCATTTGCGACAGCATTT
GCTACCTGCTCCAGCTCAGCGACCCTTCCCTCTATGATGAAGTGCATTGAAGAGAACAAT
GGTGTGGACAAGAGGATCAGCAGGTTTATTCTCCCCATCGGGGCCACCGTGAACATGGAC
GGAGCAGCCATCTTCCAGTGTGTGGCCGCGGTGTTCATTGCGCAACTCAACAACATAGAG
CTCAACGCAGGACAGATTTTCACCATTCTAGTGACTGCCACAGCGTCCAGTGTTGGAGCA
GCAGGCGTGCCAGCTGGAGGGGTCCTCACCATTGCCATTATCCTGGAGGCCATTGGGCTG
CCTACTCATGACCTGCCTCTGATCCTGGCTGTGGACTGGATTGTGGACCGGACCACCACG
GTGGTGAATGTGGAAGGGGATGCCCTGGGTGCAGGCATTCTCCACCACCTGAATCAGAAG
GCAACAAAGAAAGGCGAGCAGGAACTTGCTGAGGTGAAAGTGGAAGCCATCCCCAACTGC
AAGTCTGAGGAGGAGACATCGCCCCTGGTGACACACCAGAACCCCGCTGGCCCCGTGGCC
AGTGCCCCAGAACTGGAATCCAAGGAGTCGGTTCTGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
L14595

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_4_Locus:
2p15-p13

# Macromolecular_Interacting_Partner_4_SNPs:
rs759458; rs7563131; rs7559202; rs7589132; rs7850; rs1058922; rs1058926; rs3796052; rs7563257; rs10197339; rs7574431; rs2075209; rs3732062; rs6546119; rs6728107; rs6546120; rs1060315; rs2422358; rs11891502; rs12617488; rs3770705; rs10194230; rs2268483; rs1541580; rs11891647; rs7570684; rs3819816; rs7588457; rs7583682; rs7586345; rs7559797; rs11904597; rs17029749; rs11886554; rs2268481; rs11687321; rs11890755; rs2300546; rs7580228; rs2007061; rs1861443; rs7601530; rs7601029; rs7574973; rs11689731; rs17029736; rs12615879; rs7601562; rs7601142; rs7566124; rs17029737; rs11900188; rs11675218; rs12615528; rs7605525; rs7605452; rs17029771; rs7425340; rs1064512; rs34259099; rs6756968; rs34416635; rs13398698; rs35024658; rs12620864; rs7609068; rs12620890; rs13416211; rs7608915; rs3839063; rs34497145; rs7563137; rs11283317; rs35937278; rs35342526; rs35002509; rs10173484; rs2160387; rs5831732; rs2300548; rs10190648; rs34956531; rs34093121; rs2422359; rs17624279; rs10659734; rs3216589; rs34617398; rs34461710; rs34352138; rs10176896; rs7569409; rs11343144; rs36110974; rs34954546; rs11277470; rs2300547; rs11352632; rs6706035; rs10659733; rs35815508; rs17029731; rs2268479; rs34557334; rs2268482; rs13032158; rs34790840; rs34330989; rs11343057; rs35311819; rs34807901; rs11352633; rs10572273; rs34203436; rs35022766; rs7585341; rs1056703; rs9808015; rs13010290; rs6712347; rs10182988; rs3770707; rs7559886; rs6750052; rs7592468; rs11449616; rs34467179; rs34598433; rs7592015; rs34799701; rs35470885; rs35894508; rs11888075; rs2268480; rs13392255; rs3770706; rs34821720; rs2268478; rs11292885; rs2110950; rs11274301; rs7569840; rs11542203; rs1008617; rs11390852; rs12998384; rs7604992; rs10170033; rs10193537; rs7608786; rs35490784; rs10209552; rs10211524; rs12464724; rs17669826; rs2422435; rs2540966; rs2540967; rs2540969; rs2540970; rs2723076; rs35528068; rs6546118; rs7574847; rs9677813

# Macromolecular_Interacting_Partner_4_General_References:
8101838; 8340364; 7896285

# Macromolecular_Interacting_Partner_4_References:
Not Available

# Macromolecular_Interacting_Partner_5_ID:
8881

# Macromolecular_Interacting_Partner_5_Name:
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

# Macromolecular_Interacting_Partner_5_Synonyms:
Amino acid transporter ATB0+; Solute carrier family 6 member 14

# Macromolecular_Interacting_Partner_5_Gene_Name:
SLC6A14

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Sodium and chloridedependent neutral and basic amino acid transporter B0+
MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVW
RFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGIT
MVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNK
GIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLA
LCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQ
SNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVF
AGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLG
LDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHF
CAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAI
FIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCC
RPASNWGPYLEQHRGERYKDMVDPKKEADHEIPTVSGSRKPE

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
642

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
72154

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
8.27

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
 Function:  transporter activity
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_5_Signals:
1-469

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
45-65
72-92
110-130
235-255
261-281
315-335
348-368
399-419
450-477
480-500
528-548
563-583

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
5732680

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
S6A14_HUMAN (Q9UN76)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
SLC6A14

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
SLC6A14

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:11047

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1929 bp
ATGGACAAGTTGAAATGCCCGAGTTTCTTCAAGTGCAGGGAGAAGGAGAAAGTGTCGGCT
TCATCAGAGAATTTCCATGTTGGTGAAAATGATGAGAATCAGGACCGTGGTAACTGGTCC
AAAAAATCGGATTATCTTCTATCTATGATTGGATACGCAGTGGGATTAGGAAATGTGTGG
AGATTTCCATATCTGACCTACAGCAATGGTGGAGGCGCCTTCTTGATACCTTATGCAATT
ATGTTAGCATTGGCTGGTTTACCTTTGTTCTTTCTGGAGTGTTCACTGGGACAATTTGCT
AGCTTAGGTCCAGTTTCAGTTTGGAGGATTCTTCCATTGTTTCAAGGTGTGGGAATTACA
ATGGTCCTGATCTCCATTTTTGTGACAATCTATTACAATGTCATAATTGCCTATAGTCTT
TACTACATGTTTGCTTCTTTTCAAAGTGAACTACCATGGAAAAATTGTTCTTCGTGGTCA
GATAAAAACTGTAGCAGATCACCAATAGTAACTCACTGTAATGTGAGTACAGTGAATAAA
GGAATACAAGAGATCATCCAAATGAATAAAAGCTGGGTAGACATCAACAATTTTACCTGC
ATCAACGGCAGTGAAATTTATCAGCCAGGGCAGCTTCCCAGTGAACAATATTGGAATAAA
GTGGCGCTCCAACGGTCAAGTGGAATGAATGAGACTGGAGTAATTGTTTGGTATTTAGCA
CTTTGTCTTCTTCTGGCTTGGCTCATAGTTGGAGCAGCACTATTTAAAGGAATCAAATCG
TCTGGCAAGGTGGTATATTTTACAGCTCTTTTCCCCTATGTGGTCCTACTCATCCTGTTA
GTACGAGGTGCAACTCTGGAGGGTGCTTCAAAAGGCATTTCATACTATATTGGAGCCCAG
TCAAATTTTACAAAACTTAAGGAAGCTGAGGTATGGAAAGATGCTGCCACTCAGATATTT
TACTCCCTTTCAGTGGCTTGGGGTGGCTTAGTTGCTCTATCATCTTACAATAAGTTCAAA
AACAACTGCTTCTCTGATGCCATTGTGGTTTGTTTGACAAACTGTCTCACTAGCGTGTTT
GCTGGATTTGCTATTTTTTCTATATTGGGACACATGGCCCATATATCTGGAAAGGAAGTT
TCTCAAGTTGTAAAATCAGGTTTTGATTTGGCATTCATTGCCTATCCAGAGGCTCTAGCC
CAACTCCCAGGTGGTCCATTTTGGTCCATATTATTTTTTTTCATGCTTTTAACTTTGGGT
CTCGATTCTCAGTTTGCTTCGATTGAAACGATCACAACAACAATTCAAGATTTATTTCCC
AAAGTGATGAAGAAAATGAGGGTTCCCATAACTTTGGGCTGCTGCTTGGTTTTGTTTCTC
CTTGGTCTCGTCTGTGTGACTCAGGCTGGAATTTACTGGGTTCATCTGATTGACCACTTC
TGTGCTGGATGGGGCATTTTAATTGCAGCTATACTGGAGCTAGTTGGAATCATCTGGATT
TATGGAGGGAACAGATTCATTGAGGATACAGAAATGATGATTGGAGCAAAGAGGTGGATA
TTCTGGCTATGGTGGAGAGCTTGCTGGTTTGTAATTACGCCTATCCTTTTGATTGCAATA
TTTATCTGGTCATTGGTGCAATTTCATAGACCTAATTATGGCGCAATTCCATACCCTGAC
TGGGGAGTTGCTTTAGGCTGGTGTATGATTGTTTTCTGCATTATTTGGATACCAATTATG
GCTATCATAAAAATAATTCAGGCTAAAGGAAACATCTTTCAACGCCTTATAAGTTGCTGC
AGACCAGCTTCTAACTGGGGTCCATACCTGGAACAACATCGTGGGGAAAGATATAAAGAC
ATGGTAGATCCTAAAAAAGAGGCTGACCATGAAATACCTACTGTTAGTGGCAGCAGAAAA
CCGGAATGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AF151978

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_5_Locus:
Xq23-q24

# Macromolecular_Interacting_Partner_5_SNPs:
rs12720074; rs2011162; rs5905179; rs12710570; rs5905289; rs2011198; rs2312055; rs2032525; rs5905176; rs5905284; rs7059155; rs2071877; rs4824325; rs10217924; rs5905178; rs6608646; rs12392462; rs2312057; rs12391221; rs17242824; rs5905288; rs12559530; rs10218102; rs10521579; rs12710569; rs10521578; rs5905285; rs5952101; rs12720080; rs12720088; rs5952099; rs12720083; rs5905177; rs4824358; rs4824324; rs12720076; rs4824359; rs12720084; rs12720079; rs5952103; rs2312056; rs12720089; rs17095419; rs12393509; rs4824323; rs2312054; rs7052454; rs12710568; rs12720073; rs12834312; rs3788766; rs5905283; rs12720085; rs28523889; rs6608648; rs11350870; rs34685017; rs28699570; rs12720092; rs28628632; rs12720078; rs5952174; rs35604008; rs5952104; rs5905287; rs6608645; rs12388847; rs10629819; rs12720087; rs12720091; rs35269408; rs17308739; rs3043424; rs35542990; rs5952100; rs5952102; rs35201069; rs6651554; rs12720077; rs10218234; rs6608647; rs12858125; rs34117081; rs5952175; rs12720082; rs34490652; rs4068397; rs7066547; rs7054956; rs12832551; rs10218418; rs12720075; rs12720086; rs12720090; rs35315031; rs7062559; rs10218017; rs12390279; rs12833869; rs12835480; rs12839137; rs12844003; rs17308697; rs2103697; rs2301451; rs5952181; rs6520234; rs6608511; rs6608514; rs6608644; rs6608650

# Macromolecular_Interacting_Partner_5_General_References:
10446133

# Macromolecular_Interacting_Partner_5_References:
Not Available

# Macromolecular_Interacting_Partner_6_ID:
8882

# Macromolecular_Interacting_Partner_6_Name:
Threonine synthase-like 1

# Macromolecular_Interacting_Partner_6_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_6_Gene_Name:
THNSL1

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Threonine synthaselike 1
MLHFNRCHHLKKITQKCFSSIHVKTDKHAQRFLSRTFALAELRKSWYSTHSLVGDKNIIL
MGPPGAGKTTVGRIIGQKLGCCVIDVDDDILEKTWNMSVSEKLQDVGNEQFLEEEGKAVL
NFSASGSVISLTGSNPMHDASMWHLKKNGIIVYLDVPLLDLICRLKLMKTDRIVGQNSGT
SMKDLLKFRRQYYKKWYDARVFCESGASPEEVADKVLNAIKRYQDVDSETFISTRHVWPE
DCEQKVSAKFFSEAVIEGLASDGGLFVPAKEFPKLSCGEWKSLVGATYVERAQILLERCI
HPADIPAARLGEMIETAYGENFACSKIAPVRHLSGNQFILELFHGPTGSFKDLSLQLMPH
IFAHCIPPSCNYMILVATSGDTGSAVLNGFSRLNKNDKQRIAVVAFFPENGVSDFQKAQI
IGSQRENGWAVGVESDFDFCQTAIKRIFNDSDFTGFLTVEYGTILSSANSINWGRLLPQV
VYHASAYLDLVSQGFISFGSPVDVCIPTGNFGNILAAVYAKMMGIPIRKFICASNQNHVL
TDFIKTGHYDLRERKLAQTFSPSIDILKSSNLERHLHLMANKDGQLMTELFNRLESQHHF
QIEKALVEKLQQDFVADWCSEGECLAAINSTYNTSGYILDPHTAVAKVVADRVQDKTCPV
IISSTAHYSKFAPAIMQALKIKEINETSSSQLYLLGSYNALPPLHEALLERTKQQEKMEY
QVCAADMNVLKSHVEQLVQNQFI

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
743

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
83071

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
7.13

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
 Function:  lyase activity
Function:  carbon-oxygen lyase activity
Function:  carbon-oxygen lyase activity, acting on phosphates
Function:  threonine synthase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  shikimate kinase activity
Function:  catalytic activity
 ||
>>>
 Process:  aspartate family amino acid metabolism
Process:  threonine metabolism
Process:  threonine biosynthesis
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  amino acid biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Cell wall/membrane/envelope biogenesis

# Macromolecular_Interacting_Partner_6_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00291:PALP
PF01202:SKI

# Macromolecular_Interacting_Partner_6_Signals:
Not Available

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
THNSL_HUMAN (Q8IYQ7)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
THNSL1

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
THNSL1

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:26160

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
BC035132

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_6_Locus:
10p12.1

# Macromolecular_Interacting_Partner_6_SNPs:
rs35827877; rs34929144; rs4748997; rs7086282; rs1388926; rs4748996; rs11014349; rs11014351; rs11014350; rs11014347; rs11014348; rs11598879; rs10828740; rs12256642; rs12249889; rs35746529; rs41279890; rs41279894; rs17853392; rs41279892; rs17857051; rs34206149; rs12246243; rs11281554; rs36036021; rs10828738; rs7089295; rs7919641; rs35824003; rs36007062; rs28733953; rs7920740; rs10548669; rs7100581; rs35904469; rs13376714; rs41279888; rs12767659; rs1000825; rs1000875; rs10764518; rs10764519; rs10828741; rs11014343; rs11014353; rs11014354; rs11014355; rs11014356; rs11014357; rs12244626; rs12244683; rs12359325; rs12785191; rs1546097; rs2131276; rs2291583; rs2291585; rs2291586; rs6482467; rs7094735; rs7393543; rs7913853; rs902904; rs902905; rs987274

# Macromolecular_Interacting_Partner_6_General_References:
Not Available

# Macromolecular_Interacting_Partner_6_References:
Not Available

End of HMDB00167

Beginning of HMDB00168
# Accession_No:
HMDB00168

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-10 14:49:31

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
L-Asparagine

# Description:
Asparagine (Asn) is one of the 20 most common natural amino acids on Earth. It has carboxamide as the side chain's functional group. It is considered a non-essential amino acid. Asparagine is not an essential amino acid, which means that it can be synthesized from central metabolic pathway intermediates in humans and is not required in the diet. The precursor to asparagine is oxaloacetate. Oxaloacetate is converted to aspartate using a transaminase enzyme. The enzyme transfers the amino group from glutamate to oxaloacetate producing alpha-ketoglutarate and aspartate. The enzyme asparagine synthetase produces asparagine, AMP, glutamate, and pyrophosphate from aspartate, glutamine, and ATP. In the asparagine synthetase reaction, ATP is used to activate aspartate, forming beta-aspartyl-AMP. Glutamine donates an ammonium group which reacts with beta-aspartyl-AMP to form asparagine and free AMP. Since the asparagine side chain can make efficient hydrogen bond interactions with the peptide backbone, asparagines are often found near the beginning and end of alpha-helices, and in turn motifs in beta sheets. Its role can be thought as "capping" the hydrogen bond interactions which would otherwise need to be satisfied by the polypeptide backbone. Glutamines have an extra methylene group, have more conformational entropy and thus are less useful in this regard. Asparagine also provides key sites for N-linked glycosylation, modification of the protein chain with the addition of carbohydrate chains. A reaction between asparagine and reducing sugars or reactive carbonyls produces acrylamide (acrylic amide) in food when heated to sufficient temperature, i.e. baking. These occur primarily in baked goods such as french fries, potato chips, and roasted coffee.  Asparagine was first isolated in 1806 from asparagus juice, in which it is abundant--hence its name--becoming the first amino acid to be isolated. The smell observed in the urine of some individuals after their consumption of asparagus is attributed to a byproduct of the metabolic breakdown of asparagine, asparagine-amino-succinic-acid monoamide. (However, some scientists disagree and implicate other substances in the smell, especially methanethiol). (http://en.wikipedia.org/wiki/Asparagine)

# Synonyms:
(-)-Asparagine; (S)-2,4-Diamino-4-oxobutanoate; (S)-2,4-Diamino-4-oxobutanoic acid; (S)-Asparagine; 2-Aminosuccinamate; 2-Aminosuccinamic acid; Agedoite; Altheine; Asn; Asparagine; Asparagine acid; Asparamide; Aspartamate; Aspartamic acid; Aspartic acid amide; Aspartic acid b-amide; Aspartic acid beta amide; B2,4-(S)-diamino-4-oxo-utanoate; B2,4-(S)-diamino-4-oxo-utanoic acid; Crystal VI; L-2,4-Diamino-4-oxobutanoate; L-2,4-Diamino-4-oxobutanoic acid; L-Aspartamine; L-b-Asparagine; L-beta-Asparagine; a-Aminosuccinamate; a-Aminosuccinamic acid; alpha Amminosuccinamate; alpha Amminosuccinamic acid; alpha-Aminosuccinamate; alpha-Aminosuccinamic acid; l-Asparagine

# Chemical_IUPAC_Name:
2,4-diamino-4-oxo-butanoic acid

# Chemical_Formula:
C4H8N2O3

# Chemical_Structure:
tbl_chemical:::HMDB00168_ZOOM.png:::119283230828260330

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00168_THUMB.png:::119283230659228927

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids; Nitrogenous Compounds

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid; primary carboxylic acid amide; alpha-aminoacid

# Taxonomy_Biofunction:
Essential amino acid; Component of Alanine and aspartate metabolism; Component of Aminoacyl-tRNA biosynthesis; Component of Nitrogen metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
132.05350

# Molecular_Weight_Avg:
132.11792

# Smiles_String_isomeric:
N[C@@H](CC(N)=O)C(O)=O

# Smiles_String_canonical:
NC(CC(N)=O)C(O)=O

# KEGG_Compound_ID:
C00152

# BioCyc_ID:
ASN

# PubChem_CID:
6267

# PubChem_SID:
3452; 818771; 829680; 825668; 3137254; 8144629; 818759; 841115; 7885982; 10533427; 149195; 11110064; 8153947

# OMIM_ID:
201910; 276000

# Metagene_ID:
ASPARTYLGLUCOSAMINURIA: 65

# BiGG_ID:
34055

# Wikipedia_ID:
Asn

# METLIN_ID:
14

# Ref_ID:
16027730; 12557291; 16844612; 15911239; 15270080; 12297216; 14992292; 15835923; 1281977; 15284236; 16239337; 15849197; 7914846; 15828851; 15875186; 6198473

# ChEBI_ID:
17196

# CAS_Registry_Number:
70-47-3

# InChI:
InChI=1/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1

# Synthesis_Reference:
Biochemical and Biophysical Research Communications  (1987),  145(2),  908-14

# Melting_Point:
234-235 oC

# Melting_Point_predicted:
36.2 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
29.4 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
168.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-3.82 [CHMELIK,J ET AL. (1991)]

# LogP_predicted:
-3.35 [Predicted by ALOGPS]; -4.4 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::L-Asparagine.pdf:::1132562210293736673

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::L-Asparagine.mol:::113272381162584345

# SDF_File_[Text]:
tbl_chemical:::HMDB00168.sdf:::119283230287312914

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00168.pdb:::119283230490652753

# PDB_ID:
1POK

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::041017_P00_01_HW_1DC_26.jpg:::114168460066731055

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041017_P00_01_HW_1DC_26.zip:::114168460063968857

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041017_P00_01_HW_1DC_26_Assigned.jpg:::115920741039765413

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041017_P00_01_HW_2DHSQC_504.jpg:::11461651978323570

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041017_P00_01_HW_2DHSQC_504.zip:::114616519784035585

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041017_P00_01_HW_2DHSQC_504_Assigned.jpg:::115887549458921613

# Predicted_H_NMR_Spectrum:
tbl_chemical:::L-Asparagine.gif:::1132732117187860982

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00168_peaks.txt:::1156309592784285065

# Predicted_C_NMR_Spectrum:
tbl_chemical:::L-Asparagine_C.gif:::1132737709051690372

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00168_peaks.txt:::1156310782322266057

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00168L.png:::117555261914016382; Medium Energy:tbl_ms:::HMDB00168M.png:::117555267047595731; High Energy:tbl_ms:::HMDB00168H.png:::117555270903542743

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000030.png:::116890823315699721

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000030.txt:::116890823315678457

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000030.png:::116890823287555477

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000030.txt:::116890823315640722

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	9.211 (3.289-15.1)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Blood	41.0 (31.0-51.0)	umol/L	Adult:>18_yrs_old	Both	Normal	12297216
Blood	48.0 +/- 7.0	umol/L	Children:1-13_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	46.0 +/- 7.0	umol/L	Children:1-13_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	49.0 +/- 7.0	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	47.0 +/- 9.0	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	4.43 (0.0-8.86)	uM	Adult:>18_yrs_old	Both	Normal	HMP experimental
Cerebrospinal_Fluid(CSF)	19.0 +/- 11.1	umol/L	Children:1-13_yrs_old	N/A	Normal	15911239
Cerebrospinal_Fluid(CSF)	8.1 +/- 4.9	umol/L	Adult:>18_yrs_old	Male	Normal	6198473
Cerebrospinal_Fluid(CSF)	9.0 +/- 4.2	umol/L	Adult:>18_yrs_old	Female	Normal	6198473
Cerebrospinal_Fluid(CSF)	5.4 +/- 1.4	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	6.20 (5.90-6.50)	umol/L	Adult:>18_yrs_old	Both	Normal	14992292


# Concentration_[Abnormal]:
Blood	39.9 (36.7-43.1)	umol/L	Adult:>18_yrs_old	Both	Acute seizures	14992292
Cerebrospinal_Fluid(CSF)	7.9 +/- 6.4	umol/L	N/A	N/A	Leukemia with CNS disease	15911239
Cerebrospinal_Fluid(CSF)	11.1 +/- 6.7	umol/L	N/A	N/A	leukemia	15911239


# Associated_Disorders:
Acute Lymphoblastic Leukemia; Acute seizures; Juvenile myoclonic epilepsy (JME); leukemia; Leukemia with CNS disease; Refractory Localization-Related Epilepsy (RLE)

# Pathway_Names:
Alanine and aspartate metabolism

# Pathway_Images:
Aspartate_and_Alanine_metabolism.jpg

# KEGG_Images:
map00252

# Pathway_Graphs:
Aspartate_and_Alanine_metabolism_Graph.jpg

# Pathway_SBMLs:
Aspartate_and_Alanine_metabolism.xml

# Metabolic_Enzyme_1_ID:
5855

# Metabolic_Enzyme_1_Name:
Asparagine synthetase [glutamine-hydrolyzing]

# Metabolic_Enzyme_1_Synonyms:
Glutamine- dependent asparagine synthetase; Cell cycle control protein TS11

# Metabolic_Enzyme_1_Gene_Name:
ASNS

# Metabolic_Enzyme_1_Protein_Sequence:
>Asparagine synthetase glutaminehydrolyzing
MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRLAVVDPLFGMQ
PIRVKKYPYLWLCYNGEIYNHKKMQQHFEFEYQTKVDGEIILHLYDKGGIEQTICMLDGV
FAFVLLDTANKKVFLGRDTYGVRPLFKAMTEDGFLAVCSEAKGLVTLKHSATPFLKVEPF
LPGHYEVLDLKPNGKVASVEMVKYHHCRDVPLHALYDNVEKLFPGFEIETVKNNLRILFN
NAVKKRLMTDRRIGCLLSGGLDSSLVAATLLKQLKEAQVQYPLQTFAIGMEDSPDLLAAR
KVADHIGSEHYEVLFNSEEGIQALDEVIFSLETYDITTVRASVGMYLISKYIRKNTDSVV
IFSGEGSDELTQGYIYFHKAPSPEKAEEESERLLRELYLFDVLRADRTTAAHGLELRVPF
LDHRFSSYYLSLPPEMRIPKNGIEKHLLRETFEDSNLIPKEILWRPKEAFSDGITSVKNS
WFKILQEYVEHQVDDAMMANAAQKFPFNTPKTKEGYYYRQVFERHYPGRADWLSHYWMPK
WINATDPSARTLTHYKSAVKA

# Metabolic_Enzyme_1_Number_of_Residues:
561

# Metabolic_Enzyme_1_Molecular_Weight:
64371

# Metabolic_Enzyme_1_Theoretical_pI:
6.85

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  asparagine synthase (glutamine-hydrolyzing) activity
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Function:  asparagine synthase (glutamine-hydrolyzing) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aspartate family amino acid metabolism
Process:  asparagine metabolism
Process:  asparagine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate

# Metabolic_Enzyme_1_Pathway:
map00252  Alanine and aspartate metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_1_Reaction:
ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00733:Asn_synthase;
PF00310:GATase_2

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 6.3.5.4

# Metabolic_Enzyme_1_GenBank_ID_Protein:
179100

# Metabolic_Enzyme_1_SwissProt_ID:
ASNS_HUMAN (P08243)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ASNS

# Metabolic_Enzyme_1_Geneatlas_id:
ASNS

# Metabolic_Enzyme_1_hgnc_id:
HGNC:753

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1686 bp
ATGTGTGGCATTTGGGCGCTGTTTGGCAGTGATGATTGCCTTTCTGTTCAGTGTCTGAGT
GCTATGAAGATTGCACACAGAGGTCCAGATGCATTCCGTTTTGAGAATGTCAATGGATAC
ACCAACTGCTGCTTTGGATTTCACCGGTTGGCGGTAGTTGACCCGCTGTTTGGAATGCAG
CCAATTCGAGTGAAGAAATATCCGTATTTGTGGCTCTGTTACAATGGTGAAATCTACAAC
CATAAGAAGATGCAACAGCATTTTGAATTTGAATACCAGACCAAAGTGGATGGTGAGATA
ATCCTTCATCTTTATGACAAAGGAGGAATTGAGCAAACAATTTGTATGTTGGATGGTGTG
TTTGCATTTGTTTTACTGGATACTGCCAATAAGAAAGTGTTCCTGGGTAGAGATACATAT
GGAGTCAGACCTTTGTTTAAAGCAATGACAGAAGATGGATTTTTGGCTGTATGTTCAGAA
GCTAAAGGTCTTGTTACATTGAAGCACTCCGCGACTCCCTTTTTAAAAGTGGAGCCTTTT
CTTCCTGGACACTATGAAGTTTTGGATTTAAAGCCAAATGGCAAAGTTGCATCCGTGGAA
ATGGTTAAATATCATCACTGTCGGGATGTACCCCTGCACGCCCTCTATGACAATGTGGAG
AAACTCTTTCCAGGTTTTGAGATAGAAACTGTGAAGAACAACCTCAGGATCCTTTTTAAT
AATGCTGTAAAGAAACGTTTGATGACAGACAGAAGGATTGGCTGCCTTTTATCAGGGGGC
TTGGACTCCAGCTTGGTTGCTGCCACTCTGTTGAAGCAGCTGAAAGAAGCCCAAGTACAG
TATCCTCTCCAGACATTTGCAATTGGCATGGAAGACAGCCCCGATTTACTGGCTGCTAGA
AAGGTGGCAGATCATATTGGAAGTGAACATTATGAAGTCCTTTTTAACTCTGAGGAAGGC
ATTCAGGCTCTGGATGAAGTCATATTTTCCTTGGAAACTTATGACATTACAACAGTTCGT
GCTTCAGTAGGTATGTATTTAATTTCCAAGTATATTCGGAAGAACACAGATAGCGTGGTG
ATCTTCTCTGGAGAAGGATCAGATGAACTTACGCAGGGTTACATATATTTTCACAAGGCT
CCTTCTCCTGAAAAAGCCGAGGAGGAGAGTGAGAGGCTTCTGAGGGAACTCTATTTGTTT
GATGTTCTCCGCGCAGATCGAACTACTGCTGCCCATGGTCTTGAACTGAGAGTCCCATTT
CTAGATCATCGATTTTTTTCCTATTACTTGTCTCTGCCACCAGAAATGAGAATTCCAAAG
AATGGGATAGAAAAACATCTCCTGAGAGAGACGTTTGAGGATTCCAATCTGATACCCAAA
GAGATTCTCTGGCGACCAAAAGAAGCCTTCAGTGATGGAATAACTTCAGTTAAGAATTCC
TGGTTTAAGATTTTACAGGAATACGTTGAACATCAGGTTGATGATGCAATGATGGCAAAT
GCAGCCCAGAAATTTCCCTTCAATACTCCTAAAACCAAAGAAGGATATTACTACCGTCAA
GTCTTTGAACGCCATTACCCAGGCCGGGCTGACTGGCTGAGCCATTACTGGATGCCCAAG
TGGATCAATGCCACTGACCCTTCTGCCCGCACGCTGACCCACTACAAGTCAGCTGTCAAA
GCTTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M27396

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_1_Locus:
7q21.3

# Metabolic_Enzyme_1_SNPs:
rs1049674; rs6465630; rs7800135; rs4727378; rs7790127; rs11486966; rs11771498; rs17345759; rs17169191; rs3735557; rs11767463; rs17169211; rs17169200; rs3832527; rs17169208; rs2237287; rs7810919; rs7781469; rs10253639; rs12704947; rs7792744; rs1017070; rs7811643; rs2074891; rs7797354; rs2394741; rs4729386; rs4727377; rs17169185; rs4729388; rs17279084; rs2237289; rs17344752; rs12113193; rs4568556; rs1986082; rs10486011; rs10263979; rs2302088; rs11768092; rs13239311; rs10278321; rs17169184; rs7779490; rs12669125; rs4634561; rs17345286; rs7810492; rs17131823; rs11773753; rs4729387; rs17169186; rs11976728; rs1974562; rs3757674; rs10447748; rs3757676; rs3757675; rs17169214; rs7803055; rs12670261; rs12672215; rs13224424; rs2070159; rs11554428; rs3179866; rs1803163; rs11554429; rs11554431; rs1049677; rs3735556; rs34050735; rs11554430; rs35467050; rs34856818; rs3832526; rs13227174; rs34170799; rs28525152; rs10261245; rs6959868; rs28505181; rs36063366; rs13437661; rs10231594; rs35910902; rs28393117; rs13240259; rs28681292; rs41278833; rs2237288; rs12704948; rs13227443; rs41278827; rs10281896; rs28576085; rs10277835; rs36021744; rs13227408; rs41278830; rs10261265; rs41278824; rs13227432; rs35525774; rs12671902; rs13227317; rs13227319; rs34781568; rs13235208; rs35358974; rs35190368; rs34980123; rs28568790; rs13237150; rs36101543; rs36145892; rs13311082; rs12668015; rs28675065; rs35939272; rs34857173; rs10486009; rs10486010; rs11975817; rs13230541; rs2530121; rs6966699; rs7798362; rs7800746; rs9641216

# Metabolic_Enzyme_1_General_References:
2886907; 2565875; 12853948; 3470743; 2569668; 2564390; 2573597

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5883

# Metabolic_Enzyme_2_Name:
Asparaginyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_2_Synonyms:
Asparagine-- tRNA ligase; AsnRS

# Metabolic_Enzyme_2_Gene_Name:
NARS

# Metabolic_Enzyme_2_Protein_Sequence:
>AsparaginyltRNA synthetase, cytoplasmic
MVLAELYVSDREGSDATGDGTKEKPFKTGLKALMTVGKEPFPTIYVDSQKENERWNVISK
SQLKNIKKMWHREQMKSESREKKEAEDSLRREKNLEEAKKITIKNDPSLPEPKCVKIGAL
EGYRGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLADELCQCYNGVLLSTESSVA
VYGMLNLTPKGKQAPGGHELSCDFWELIGLAPAGGADNLINEESDVDVQLNNRHMMIRGE
NMSKILKARSMVTRCFRDHFFDRGYYEVTPPTLVQTQVEGGATLFKLDYFGEEAFLTQSS
QLYLETCLPALGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFLTFDDLLNRLEDLVCD
VVDRILKSPAGSIVHELNPNFQPPKRPFKRMNYSDAIVWLKEHDVKKEDGTFYEFGEDIP
EAPERLMTDTINEPILLCRFPVEIKSFYMQRCPEDSRLTESVDVLMPNVGEIVGGSMRIF
DSEEILAGYKREGIDPTPYYWYTDQRKYGTCPHGGYGLGLERFLTWILNRYHIRDVCLYP
RFVQRCTP

# Metabolic_Enzyme_2_Number_of_Residues:
548

# Metabolic_Enzyme_2_Molecular_Weight:
62944

# Metabolic_Enzyme_2_Theoretical_pI:
6.17

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  aspartate-tRNA ligase activity
Function:  nucleic acid binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  asparagine-tRNA ligase activity
 ||
>>>
Process:  aspartyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  asparaginyl-tRNA aminoacylation
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_2_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_2_Specific_Function:
ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)

# Metabolic_Enzyme_2_Pathway:
map00252  Alanine and aspartate metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_2_Reaction:
ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00152:tRNA-synt_2;
PF01336:tRNA_anti

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 6.1.1.22

# Metabolic_Enzyme_2_GenBank_ID_Protein:
2764505

# Metabolic_Enzyme_2_SwissProt_ID:
SYNC_HUMAN (O43776)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
NARS

# Metabolic_Enzyme_2_Geneatlas_id:
NARS

# Metabolic_Enzyme_2_hgnc_id:
HGNC:7643

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1647 bp
ATGGTGCTAGCAGAGCTGTACGTCTCTGACCGAGAGGGAAGCGATGCCACGGGAGATGGA
ACCAAGGAGAAACCATTTAAAACAGGTCTAAAGGCTTTGATGACAGTAGGGAAAGAACCA
TTTCCTACCATTTACGTAGATTCACAAAAAGAAAATGAGAGGTGGAATGTTATTTCTAAA
TCACAGTTGAAGAACATTAAAAAGATGTGGCATAGGGAACAAATGAAGAGTGAATCCCGG
GAAAAGAAAGAGGCAGAAGATAGTTTACGAAGAGAAAAGAACCTGGAAGAAGCAAAGAAG
ATTACCATTAAAAATGATCCAAGTCTCCCAGAGCCAAAATGTGTGAAGATTGGTGCGTTA
GAAGGATATAGAGGCCAAAGAGTAAAGGTGTTTGGCTGGGTCCACAGGCTGCGCAGGCAA
GGAAAGAATTTAATGTTTCTGGTGTTGCGAGATGGTACAGGTTATCTTCAGTGTGTCTTG
GCGGATGAGTTGTGTCAGTGCTACAATGGAGTTCTCTTGTCCACGGAGAGCAGTGTTGCA
GTGTATGGAATGCTAAATCTTACCCCAAAGGGCAAGCAGGCTCCAGGTGGCCATGAGCTG
AGTTGTGACTTCTGGGAACTAATTGGGTTGGCCCCTGCTGGAGGAGCTGACAACCTGATC
AATGAGGAGTCTGACGTTGATGTCCAGCTCAACAACAGACACATGATGATCCGAGGAGAA
AACATGTCCAAAATCCTAAAAGCACGATCCATGGTCACCAGGTGCTTTAGAGATCACTTC
TTTGATAGGGGGTACTATGAAGTTACTCCTCCAACATTAGTGCAAACACAAGTAGAAGGT
GGTGCCACACTCTTCAAGCTTGACTATTTTGGGGAAGAGGCATTTTTGACTCAATCCTCT
CAGTTGTACTTGGAGACCTGCCTCCCAGCCCTGGGAGATGTTTTTTGTATTGCTCAGTCA
TACCGGGCAGAGCAGTCCAGAACACGAAGGCACCTGGCTGAGTACACTCACGTGGAAGCT
GAGTGTCCTTTCCTGACTTTTGACGACCTCCTGAACCGGTTGGAGGACTTGGTTTGTGAT
GTGGTAGATCGAATATTGAAGTCACCTGCAGGGAGCATAGTGCATGAGCTCAACCCGAAC
TTTCAGCCCCCCAAACGGCCTTTCAAACGGATGAACTATTCAGATGCTATCGTTTGGCTA
AAAGAACATGATGTAAAGAAAGAAGATGGAACTTTCTATGAATTTGGAGAAGATATCCCA
GAAGCTCCTGAGAGACTGATGACAGACACCATTAATGAACCAATCTTGCTGTGTCGATTT
CCTGTGGAGATCAAGTCCTTCTACATGCAGCGATGTCCTGAGGATTCCCGTCTTACTGAA
TCTGTCGACGTGTTGATGCCCAATGTTGGTGAGATTGTGGGAGGCTCAATGCGTATCTTT
GATAGTGAAGAAATACTGGCAGGTTATAAAAGGGAAGGGATTGACCCCACTCCCTATTAC
TGGTATACGGATCAGAGAAAATACGGTACATGTCCCCATGGAGGATATGGCTTGGGCTTG
GAACGATTCTTAACGTGGATTCTGAATAGGTATCACATCCGAGACGTGTGCTTATACCCT
CGATTTGTCCAGCGTTGCACGCCATAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AJ000334

# Metabolic_Enzyme_2_Chromosome_Location:
Not Available

# Metabolic_Enzyme_2_Locus:
Not Available

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
9421509; 9801298

# Metabolic_Enzyme_2_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8533

# Macromolecular_Interacting_Partner_1_Name:
ASRGL1 protein

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
ASRGL1

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>ASRGL1 protein
MNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILREGGSAVDAVEGAVVALEDDPE
FNAGCGSVLNTNGEVEMDASIMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPHCFLTDQ
GAAQFAAAMGVPEIPGEKLVTERNKKRLEKEKHEKGAQKTDCQKNLGTVGAVALDCKGNV
AYATSTGGIVNKMVGRVGDSPCLGAGGYADNDIGAVSTTGHGESILKVNLARLTLFHIEQ
GKTVEEAADLSLGYMKSRVKGLGGLIVVSKTGDWVAKWTSTSMPWAAAKDGKLHFGIDPD
DTTITDLP

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
308

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
32055

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.17

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Function:  asparaginase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  glycoprotein metabolism
Process:  glycoprotein catabolism
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_1_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01112:Asparaginase_2

# Macromolecular_Interacting_Partner_1_Signals:
Not Available

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
62204511

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
Q567Q4_HUMAN (Q567Q4)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
ASRGL1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
ASRGL1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:16448

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>927 bp
ATGAATCCCATCGTAGTGGTCCACGGCGGCGGAGCCGGTCCCATCTCCAAGGATCGGAAG
GAGCGAGTGCACCAGGGCATGGTCAGAGCCGCCACCGTGGGCTACGGCATCCTCCGGGAG
GGCGGGAGCGCCGTGGATGCCGTAGAGGGAGCTGTCGTCGCCCTGGAAGACGATCCCGAG
TTCAACGCAGGTTGTGGGTCTGTCTTGAACACAAATGGTGAGGTTGAAATGGATGCTAGT
ATCATGGATGGAAAAGACCTGTCTGCAGGAGCAGTGTCCGCAGTCCAGTGTATAGCAAAT
CCCATTAAACTTGCTCGGCTTGTCATGGAAAAGACACCTCATTGCTTTCTGACTGACCAA
GGCGCAGCGCAGTTTGCAGCAGCTATGGGGGTTCCAGAGATTCCTGGAGAAAAACTGGTG
ACAGAGAGAAACAAAAAGCGCCTGGAAAAAGAGAAGCATGAAAAAGGTGCTCAGAAAACA
GATTGTCAAAAAAACTTGGGAACCGTGGGTGCTGTTGCCTTGGACTGCAAAGGGAATGTA
GCCTACGCAACCTCCACAGGCGGTATCGTTAATAAAATGGTCGGCCGCGTTGGGGACTCA
CCGTGTCTAGGAGCTGGAGGTTATGCCGACAATGACATCGGAGCCGTCTCAACCACAGGG
CATGGGGAAAGCATCCTGAAGGTGAACCTGGCTAGACTCACCCTGTTCCACATAGAACAA
GGAAAGACGGTAGAAGAGGCTGCGGACCTATCGTTGGGTTATATGAAGTCAAGGGTTAAA
GGTTTAGGTGGCCTCATCGTGGTTAGCAAAACAGGAGACTGGGTGGCAAAGTGGACCTCC
ACCTCCATGCCCTGGGCAGCCGCCAAGGACGGCAAGCTGCACTTCGGAATTGATCCTGAC
GATACTACTATCACCGACCTTCCCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
BC093070

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11q12.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs3741244; rs3741245; rs4281490; rs2277281; rs2513749; rs3216739; rs15810; rs11606114; rs2302360; rs2958531; rs4432028; rs7116792; rs11822408; rs12292642; rs3018622; rs7941556; rs2513052; rs2513051; rs2958532; rs10897261; rs11820258; rs12292586; rs10897267; rs951677; rs10792346; rs10897266; rs10792351; rs11605965; rs1881535; rs11231042; rs7119235; rs7109277; rs11608211; rs11231067; rs11821255; rs10897260; rs12287823; rs2302359; rs7115632; rs2463836; rs2513738; rs10792350; rs11231053; rs12419894; rs2513077; rs2513737; rs7105219; rs11231070; rs2513054; rs7111902; rs11231069; rs7127401; rs4340061; rs2302361; rs7123323; rs11231051; rs17157218; rs11231046; rs10897259; rs7113399; rs10792347; rs11231062; rs12285902; rs7103755; rs11231045; rs11604863; rs9667211; rs11231059; rs10897264; rs11604275; rs11231068; rs10437726; rs5017020; rs7105622; rs10750974; rs12274086; rs4536220; rs2513053; rs7943362; rs11231044; rs7118756; rs11821315; rs11820150; rs11231065; rs10897265; rs11231047; rs11820997; rs7110781; rs7481995; rs7105843; rs11826669; rs10792345; rs12282077; rs11231061; rs11231055; rs4502002; rs12294413; rs11231071; rs7928732; rs2246920; rs2463822; rs2246925; rs4465372; rs2513076; rs34180063; rs5792256; rs36101350; rs17845648; rs10524135; rs28678254; rs34743439; rs34950346; rs34840364; rs35931241; rs11231056; rs11600883; rs34776557; rs34150528; rs7104831; rs12807451; rs34472338; rs7482885; rs12802498; rs34522226; rs34694043; rs34027697; rs12574213; rs11231039; rs7483087; rs35105438; rs10656254; rs11821712; rs11603424; rs35737806; rs34237835; rs11231043; rs34891208; rs36137866; rs3180047; rs4963504; rs35096038; rs12274759; rs11827263; rs11231050; rs12420033; rs35114658; rs35136967; rs10656253; rs12224129; rs2463820; rs12799816; rs34547539; rs9667654; rs3180879; rs3018619; rs11231063; rs34834191; rs12573986; rs35798082; rs12574677; rs34191855; rs11330625; rs3832779; rs11231049; rs12802501; rs7932577; rs12787924; rs7124935; rs3180880; rs3180646; rs12804628; rs2463821; rs34853836; rs3206772; rs12802660; rs35068655; rs12274607; rs2463837; rs28583008; rs5792255; rs34574964; rs11231041; rs34446979; rs10656816; rs36033542; rs35551368; rs3832778; rs12801810; rs11600424; rs7932568; rs7109686; rs12794304; rs35345092; rs34956831; rs11231048; rs34075806; rs35333346; rs35205241; rs35341808; rs11231040; rs11231060; rs35140033; rs7947190; rs35684001; rs35296627; rs35495143; rs28641974; rs12807615; rs35854084; rs34114318; rs12282415; rs11231066; rs35499940; rs7125465; rs10599499; rs35311476; rs34703429; rs10618086; rs4519096; rs1043789; rs10501332; rs11231058; rs11231073; rs11231075; rs11231076; rs11231079; rs11605111; rs11823982; rs12226795; rs12274789; rs17157227; rs2513071; rs2513075; rs2513747; rs2958530; rs3018620; rs3018621; rs34037877; rs34533893; rs35961711; rs4334021; rs4963296; rs4963499; rs4963505; rs7113294; rs7113359; rs7118241; rs7118835; rs7119797; rs7127368; rs7931774; rs7941992; rs948580

# Macromolecular_Interacting_Partner_1_General_References:
12477932

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8562

# Macromolecular_Interacting_Partner_2_Name:
System N amino acid transporter 1

# Macromolecular_Interacting_Partner_2_Synonyms:
SN1; N-system amino acid transporter 1; Solute carrier family 38 member 3

# Macromolecular_Interacting_Partner_2_Gene_Name:
SLC38A3

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>System N amino acid transporter 1
MEAPLQTEMVELVPNGKHSEGLLPVITPMAGNQRVEDPARSCMEGKSFLQKSPSKEPHFT
DFEGKTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLLTAVALLSSYSIHLLLKS
SGVVGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSYLYIIKSELPLVIQTFLNLEE
KTSDWYMNGNYLVILVSVTIILPLALMRQLGYLGYSSGFSLSCMVFFLIAVIYKKFHVPC
PLPPNFNNTTGNFSHVEIVKEKVQLQVEPEASAFCTPSYFTLNSQTAYTIPIMAFAFVCH
PEVLPIYTELKDPSKKKMQHISNLSIAVMYIMYFLAALFGYLTFYNGVESELLHTYSKVD
PFDVLILCVRVAVLTAVTLTVPIVLFPVRRAIQQMLFPNQEFSWLRHVLIAVGLLTCINL
LVIFAPNILGIFGVIGATSAPFLIFIFPAIFYFRIMPTEKEPARSTPKILALCFAMLGFL
LMTMSLSFIIIDWASGTSRHGGNH

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
504

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
55774

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
8.01

# Macromolecular_Interacting_Partner_2_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_2_Specific_Function:
Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_2_Signals:
1-111

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
83-103
106-126
144-164
187-207
213-233
324-344
366-386
408-428
431-451
471-491

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
S38A3_HUMAN (Q99624)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
SLC38A3

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
SLC38A3

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:18044

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cell membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AF244548

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_2_Locus:
3p21.3

# Macromolecular_Interacting_Partner_2_SNPs:
rs2282749; rs4141407; rs2236939; rs2236940; rs2236941; rs2236942; rs739431; rs886075; rs2282750; rs35742391; rs739430; rs2006199; rs1858828; rs13084560; rs13320226; rs13084362; rs34370846; rs35137368; rs35768187; rs13084716; rs4688744; rs13084528; rs11709574; rs11293008; rs34840478; rs35219849; rs35195846; rs9847853; rs11385619; rs35374338; rs13084685; rs13084700; rs12635271; rs34366896; rs6792754; rs13064707; rs13084344; rs13084819; rs35306902; rs6779184; rs13084686; rs6791799; rs33915788; rs3831498; rs35926495; rs34382606; rs5848902; rs11442070; rs35686060; rs34974687; rs35851247; rs5848903; rs7611366; rs35756060; rs35667988; rs11919418; rs12485909; rs12631192; rs13064381; rs34877766; rs4525859; rs4688682; rs4688683; rs4688745; rs7617915; rs9883222

# Macromolecular_Interacting_Partner_2_General_References:
10823827; 11085536

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8594

# Macromolecular_Interacting_Partner_3_Name:
SLC38A2 protein

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC38A2

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>SLC38A2 protein
MKQNLILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIG
AMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGY
TSGLSLLCMVFFLIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDS
CRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYL
LAALFGYLTFYEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTH
LLCASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIK
LVKKEPMKSVQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
406

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
45180

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
8.88

# Macromolecular_Interacting_Partner_3_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_3_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_3_Signals:
1-18

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
5-23; 48-69; 89-111; 115-137; 230-252; 272-294; 315-334; 339-361; 373-395

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
Q6IA88_HUMAN (Q6IA88)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC38A2

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC38A2

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:13448

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
CR457267

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_3_Locus:
12q

# Macromolecular_Interacting_Partner_3_SNPs:
rs10880961; rs7968283; rs956910; rs2897968; rs7968173; rs7961994; rs10880959; rs2307063; rs1873793; rs3742061; rs2307061; rs10880960; rs3782904; rs7965930; rs2307062; rs2279559; rs7974529; rs7960147; rs10785624; rs11183450; rs34139863; rs36065261; rs36022751; rs11340856; rs7966787; rs11313787; rs5797976; rs1046296; rs11183449; rs12307969; rs2307060; rs36019260; rs3837525; rs35534621; rs11183447; rs3832874; rs3830356; rs34489723; rs36066221; rs11298796; rs7295472; rs35732850; rs35944767; rs34099989; rs10880962; rs11183446; rs12368989; rs1492896; rs17096884; rs4768697; rs4768698; rs7135630; rs7967840; rs7975820; rs7979418

# Macromolecular_Interacting_Partner_3_General_References:
Not Available

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8607

# Macromolecular_Interacting_Partner_4_Name:
SLC38A5 protein

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC38A5

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>SLC38A5 protein
SIHLLLTCAGIAGIRAYEQLGQRAFGPAGKVVVATVICLHNVGAMSSYLFIIKSELPLVI
GTFLYMDPEGDWFLKGNLLIIIVSVLIILPLALMKHLGYLGYTSGLSLTCMLFFLVSVIY
KKFQLGCAIGHNETAMESEALVGLPSQGLNSSCEAQMFTVDSQMSYTVPIMAFAFVCHPE
VLPIYTELCRPSKRRMQAVANVSIGAMFCMYGLTATFGYLTFYSSVKAEMLHMYSQKDPL
ILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPGKAFSWPRHVAIALILLVLVNVLVICV
PTIRDIFGVIGSTSAPSLIFILPSIFYLRIVPSEVEPFLSWPKIQALCFGVLGVLFMAVS
LGFMFANWATGQSRMSGH

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
378

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
41426

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.47

# Macromolecular_Interacting_Partner_4_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_4_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_4_Signals:
1-16

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
31-52; 72-94; 98-120; 166-188; 198-220; 241-263; 278-300; 307-329; 344-366

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
40225675

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
Q6PIW9_HUMAN (Q6PIW9)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC38A5

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC38A5

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:18070

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1138 bp
CTCCATCCACCTCCTGCTGACCTGTGCTGGTATTGCAGGCATCCGAGCCTATGAGCAGCT
GGGACAGAGGGCATTCGGGCCTGCGGGGAAGGTAGTGGTGGCCACAGTCATCTGTCTGCA
CAATGTTGGGGCCATGTCCAGTTACCTGTTCATCATCAAATCTGAGCTCCCCCTGGTTAT
CGGCACCTTCCTGTACATGGACCCCGAGGGGGACTGGTTCTTGAAGGGAAACCTCCTCAT
CATCATCGTCAGTGTGTTAATCATCCTGCCCCTCGCCCTCATGAAACACTTGGGCTACCT
GGGGTACACCAGTGGTCTCTCTCTGACCTGCATGCTGTTTTTCCTTGTTTCGGTCATCTA
CAAGAAGTTCCAACTTGGCTGTGCTATAGGCCACAATGAAACAGCAATGGAGAGTGAAGC
TCTCGTGGGACTCCCCAGCCAAGGACTCAACAGCAGCTGTGAGGCCCAGATGTTCACAGT
TGACTCACAGATGTCCTACACAGTGCCCATTATGGCTTTTGCTTTTGTCTGCCACCCTGA
GGTGCTGCCCATCTATACGGAGCTCTGCCGGCCCTCCAAGCGCAGGATGCAGGCCGTGGC
CAACGTGTCCATTGGGGCCATGTTCTGCATGTATGGGCTCACAGCAACCTTTGGATACCT
CACCTTCTACAGCAGTGTGAAGGCGGAGATGCTGCACATGTACAGCCAGAAGGACCCGCT
CATCCTCTGTGTGCGCCTGGCCGTGCTGCTCGCGGTGACCCTCACTGTGCCAGTCGTGCT
GTTCCCTATCCGCCGGGCCCTGCAGCAGCTGCTTTTCCCAGGCAAGGCCTTCAGCTGGCC
ACGACATGTGGCCATAGCTCTGATCCTGCTTGTTTTGGTCAATGTCCTTGTCATCTGTGT
GCCAACCATCCGGGATATCTTTGGAGTTATCGGGTCCACCTCAGCCCCCAGCCTCATCTT
CATCCTCCCCAGCATCTTCTACCTCCGCATTGTACCCTCTGAGGTGGAGCCTTTCTTATC
CTGGCCCAAGATCCAGGCCCTGTGCTTTGGAGTCCTGGGAGTCCTCTTCATGGCCGTCAG
TCTAGGCTTTATGTTTGCCAACTGGGCCACAGGCCAGAGCCGCATGTCTGGACACTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
BC027721

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_4_Locus:
Xp11.23

# Macromolecular_Interacting_Partner_4_SNPs:
rs17281188; rs2293953; rs2293952; rs909322; rs12014551; rs5905691; rs2272657; rs5906670; rs17148207; rs34099520; rs12851533; rs5906672; rs12851546; rs12838813; rs6608806; rs34145896; rs28469063; rs10671203; rs4988523; rs35633286; rs35982043; rs4988522; rs2293951; rs5902424; rs5906671; rs5902425; rs35863886; rs10577901; rs4480243; rs34884148; rs10578218; rs5953238; rs34820839; rs3840968; rs10533882; rs1040344; rs12840106; rs2268954; rs2977590; rs2977591; rs4824714; rs5952506; rs7876401

# Macromolecular_Interacting_Partner_4_General_References:
12477932

# Macromolecular_Interacting_Partner_4_References:
Not Available

# Macromolecular_Interacting_Partner_5_ID:
8673

# Macromolecular_Interacting_Partner_5_Name:
Sodium-coupled neutral amino acid transporter 4

# Macromolecular_Interacting_Partner_5_Synonyms:
Na(+-coupled neutral amino acid transporter 4; Amino acid transporter A3; System A amino acid transporter 3; System N amino acid transporter 3; Solute carrier family 38 member 4

# Macromolecular_Interacting_Partner_5_Gene_Name:
SLC38A4

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Sodiumcoupled neutral amino acid transporter 4
MDPMELRNVNIEPDDESSSGESAPDSYIGIGNSEKAAMSSQFANEDTESQKFLTNGFLGK
KKLADYADEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSL
YSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEV
IRAFMGLEENTGEWYLNGNYLIIFVSVGIILPLSLLKNLGYLGYTSGFSLTCMVFFVSVV
IYKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLPNNSESSDVNFMMDYTHRNPAGLDEN
QAKGSLHDSGVEYEAHSDDKCEPKYFVFNSRTAYAIPILVFAFVCHPEVLPIYSELKDRS
RRKMQTVSNISITGMLVMYLLAALFGYLTFYGEVEDELLHAYSKVYTLDIPLLMVRLAVL
VAVTLTVPIVLFPIRTSVITLLFPKRPFSWIRHFLIAAVLIALNNVLVILVPTIKYIFGF
IGASSATMLIFILPAVFYLKLVKKETFRSPQKVGALIFLVVGIFFMIGSMALIIIDWIYD
PPNSKHH

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
547

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
60765

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.45

# Macromolecular_Interacting_Partner_5_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_5_Specific_Function:
Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_5_Signals:
1-531

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
81-101
105-125
152-172
196-216
221-241
333-353
370-390
412-432
454-474
477-497
515-535

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
13876616

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
S38A4_HUMAN (Q969I6)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
SLC38A4

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
SLC38A4

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:14679

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Cell membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1644 bp
ATGGATCCCATGGAACTGAGAAATGTCAACATCGAACCAGATGATGAGAGCAGCAGTGGA
GAAAGTGCTCCAGATAGCTACATCGGGATAGGAAATTCAGAAAAGGCAGCAATGAGCAGT
CAATTTGCTAATGAAGACACTGAAAGTCAGAAATTCCTGACAAATGGATTTTTGGGGAAA
AAGAAGCTGGCAGATTATGCTGATGAACACCATCCCGGAACCACTTCCTTTGGAATGTCT
TCATTTAACCTGAGTAATGCCATCATGGGCAGTGGGATCCTGGGCTTGTCCTATGCCATG
GCCAACACAGGGATCATACTTTTTATAATCATGCTGCTTGCTGTGGCAATATTATCACTG
TATTCAGTTCACCTTTTATTAAAAACAGCCAAGGAAGGAGGGTCTTTGATTTATGAAAAA
TTAGGAGAAAAGGCATTTGGATGGCCGGGAAAAATTGGAGCTTTTGTTTCCATTACAATG
CAGAACATTGGAGCAATGTCAAGCTACCTCTTTATCATTAAATATGAACTACCTGAAGTA
ATCAGAGCATTCATGGGACTTGAAGAAAATACTGGAGAATGGTACCTCAATGGCAACTAC
CTCATCATATTTGTGTCTGTTGGAATTATTCTTCCACTTTCGCTCCTTAAAAATTTAGGT
TATCTTGGCTATACCAGTGGATTTTCTCTTACCTGCATGGTGTTTTTTGTTAGTGTGGTG
ATTTACAAGAAATTCCAAATACCCTGCCCTCTACCTGTTTTGGATCACAGTGTTGGAAAT
CTGTCATTCAACAACACGCTTCCAATGCATGTGGTAATGTTACCCAACAACTCTGAGAGT
TCTGATGTGAACTTCATGATGGATTACACCCACCGCAATCCTGCAGGGCTGGATGAGAAC
CAGGCCAAGGGCTCTCTTCATGACAGTGGAGTAGAATATGAAGCTCATAGTGATGACAAG
TGTGAACCCAAATACTTTGTATTCAACTCCCGGACGGCCTATGCAATTCCTATCCTAGTA
TTTGCTTTTGTATGCCACCCTGAGGTCCTTCCCATCTACAGTGAACTTAAAGATCGGTCC
CGGAGAAAAATGCAAACGGTGTCAAATATTTCCATCACGGGGATGCTTGTCATGTACCTG
CTTGCCGCCCTCTTTGGTTACCTAACCTTCTATGGAGAAGTTGAAGATGAATTACTTCAT
GCCTACAGCAAAGTGTATACATTAGACATCCCTCTTCTCATGGTTCGCCTGGCAGTCCTT
GTGGCAGTAACACTAACTGTGCCCATTGTCCTCTTCCCAATTCGTACATCAGTGATCACA
CTGTTATTTCCCAAACGACCCTTCAGCTGGATACGACATTTCCTGATTGCAGCTGTGCTT
ATTGCACTTAATAATGTTCTGGTCATCCTTGTGCCAACTATAAAATACATCTTCGGATTC
ATAGGGGCTTCTTCTGCCACTATGCTGATTTTTATTCTTCCAGCAGTTTTTTATCTTAAA
CTTGTCAAGAAAGAAACTTTTAGGTCACCCCAAAAGGTCGGGGCTTTAATTTTCCTTGTG
GTTGGAATATTCTTCATGATTGGAAGCATGGCACTCATTATAATTGACTGGATTTATGAT
CCTCCAAATTCCAAGCATCACTAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AF305814

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_5_Locus:
12q13

# Macromolecular_Interacting_Partner_5_SNPs:
rs2429467; rs11183610; rs180414; rs2465604; rs2429472; rs2250010; rs2191162; rs2715788; rs2465608; rs2430921; rs4627160; rs11183605; rs180438; rs2897981; rs10881001; rs2079787; rs7974413; rs11183618; rs2429470; rs4482114; rs11183617; rs7963399; rs11183616; rs7967842; rs4587804; rs7132006; rs10161209; rs2109125; rs11183619; rs2465605; rs3862137; rs4569081; rs11183620; rs12321267; rs12582305; rs12424453; rs7968752; rs7954772; rs2429473; rs7963807; rs2465586; rs17097332; rs4447249; rs7138295; rs7959916; rs7953215; rs7973308; rs12304394; rs4491335; rs180437; rs12301396; rs10748455; rs2429471; rs12300935; rs4554975; rs12318696; rs10437941; rs7963364; rs10881002; rs7971412; rs7974393; rs12227634; rs17666239; rs12301345; rs11183621; rs17097341; rs10881003; rs180430; rs180431; rs2715779; rs2465585; rs180416; rs2465584; rs180421; rs1860372; rs180408; rs180433; rs180410; rs180409; rs180420; rs180417; rs7297226; rs4768758; rs2287471; rs180427; rs180419; rs2429474; rs4768759; rs2430922; rs2465583; rs6582676; rs180407; rs11183608; rs2465582; rs180434; rs180405; rs11183609; rs180426; rs180435; rs180412; rs2465644; rs12307687; rs180424; rs180429; rs180415; rs17097246; rs2075335; rs12305532; rs180428; rs12316767; rs2287472; rs12581848; rs12307218; rs4768757; rs180425; rs12317419; rs12306007; rs3794308; rs12301214; rs2302855; rs180423; rs180403; rs17097220; rs12313427; rs17602430; rs1860371; rs12826359; rs180422; rs2429465; rs2287473; rs17097286; rs11609184; rs2429466; rs180436; rs180404; rs1468970; rs1468972; rs1468971; rs2465614; rs4340151; rs2430920; rs2465613; rs12315893; rs7489259; rs7976413; rs7962993; rs7965688; rs7976286; rs4262792; rs12309262; rs35448881; rs5797999; rs12426237; rs34557682; rs10523982; rs12824626; rs2543339; rs4537845; rs34666594; rs2429469; rs10161451; rs34886536; rs5798000; rs4575359; rs11558891; rs9804926; rs10693721; rs4388977; rs2430923; rs2429468; rs34878223; rs3764027; rs2465606; rs2465588; rs35064296; rs17097355; rs34251832; rs12308177; rs1072246; rs2465587; rs4335624; rs5798001; rs2907513; rs12819255; rs4768756; rs2532606; rs11370884; rs34540549; rs12298652; rs34594658; rs4623983; rs35779004; rs35709312; rs2429464; rs10691485; rs12832145; rs35826321; rs180413; rs2216433; rs35066357; rs12319423; rs2465616; rs10691484; rs11610757; rs11315253; rs34637197; rs17097192; rs35050099; rs7313706; rs549755; rs36053062; rs11335369; rs3217194; rs11183614; rs12318924; rs4631970; rs34909119; rs12316757; rs180411; rs180432; rs10673975; rs34246069; rs35085914; rs180406; rs34654635; rs34189139; rs11335992; rs4439596; rs416435; rs35774013; rs5797998; rs3958775; rs35668113; rs446993; rs180418; rs34764764; rs34209899; rs11338774; rs10785645; rs11183625; rs11609070; rs11615573; rs12307895; rs12311057; rs12317975; rs12318756; rs12318994; rs12812119; rs17097368; rs17684703; rs2193649; rs2216432; rs2408623; rs2430917; rs2430919; rs2465595; rs2715775; rs2715783; rs4374015; rs4495962; rs4497488; rs4511364; rs4533116; rs4994910; rs7953233; rs7955552; rs7964210; rs7978689; rs7978822; rs7978926

# Macromolecular_Interacting_Partner_5_General_References:
11342143; 11414754

# Macromolecular_Interacting_Partner_5_References:
Not Available

# Macromolecular_Interacting_Partner_6_ID:
8881

# Macromolecular_Interacting_Partner_6_Name:
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

# Macromolecular_Interacting_Partner_6_Synonyms:
Amino acid transporter ATB0+; Solute carrier family 6 member 14

# Macromolecular_Interacting_Partner_6_Gene_Name:
SLC6A14

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Sodium and chloridedependent neutral and basic amino acid transporter B0+
MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVW
RFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGIT
MVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNK
GIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLA
LCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQ
SNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVF
AGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLG
LDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHF
CAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAI
FIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCC
RPASNWGPYLEQHRGERYKDMVDPKKEADHEIPTVSGSRKPE

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
642

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
72154

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
8.27

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
 Function:  transporter activity
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_6_Signals:
1-469

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
45-65
72-92
110-130
235-255
261-281
315-335
348-368
399-419
450-477
480-500
528-548
563-583

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
5732680

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
S6A14_HUMAN (Q9UN76)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SLC6A14

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SLC6A14

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:11047

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1929 bp
ATGGACAAGTTGAAATGCCCGAGTTTCTTCAAGTGCAGGGAGAAGGAGAAAGTGTCGGCT
TCATCAGAGAATTTCCATGTTGGTGAAAATGATGAGAATCAGGACCGTGGTAACTGGTCC
AAAAAATCGGATTATCTTCTATCTATGATTGGATACGCAGTGGGATTAGGAAATGTGTGG
AGATTTCCATATCTGACCTACAGCAATGGTGGAGGCGCCTTCTTGATACCTTATGCAATT
ATGTTAGCATTGGCTGGTTTACCTTTGTTCTTTCTGGAGTGTTCACTGGGACAATTTGCT
AGCTTAGGTCCAGTTTCAGTTTGGAGGATTCTTCCATTGTTTCAAGGTGTGGGAATTACA
ATGGTCCTGATCTCCATTTTTGTGACAATCTATTACAATGTCATAATTGCCTATAGTCTT
TACTACATGTTTGCTTCTTTTCAAAGTGAACTACCATGGAAAAATTGTTCTTCGTGGTCA
GATAAAAACTGTAGCAGATCACCAATAGTAACTCACTGTAATGTGAGTACAGTGAATAAA
GGAATACAAGAGATCATCCAAATGAATAAAAGCTGGGTAGACATCAACAATTTTACCTGC
ATCAACGGCAGTGAAATTTATCAGCCAGGGCAGCTTCCCAGTGAACAATATTGGAATAAA
GTGGCGCTCCAACGGTCAAGTGGAATGAATGAGACTGGAGTAATTGTTTGGTATTTAGCA
CTTTGTCTTCTTCTGGCTTGGCTCATAGTTGGAGCAGCACTATTTAAAGGAATCAAATCG
TCTGGCAAGGTGGTATATTTTACAGCTCTTTTCCCCTATGTGGTCCTACTCATCCTGTTA
GTACGAGGTGCAACTCTGGAGGGTGCTTCAAAAGGCATTTCATACTATATTGGAGCCCAG
TCAAATTTTACAAAACTTAAGGAAGCTGAGGTATGGAAAGATGCTGCCACTCAGATATTT
TACTCCCTTTCAGTGGCTTGGGGTGGCTTAGTTGCTCTATCATCTTACAATAAGTTCAAA
AACAACTGCTTCTCTGATGCCATTGTGGTTTGTTTGACAAACTGTCTCACTAGCGTGTTT
GCTGGATTTGCTATTTTTTCTATATTGGGACACATGGCCCATATATCTGGAAAGGAAGTT
TCTCAAGTTGTAAAATCAGGTTTTGATTTGGCATTCATTGCCTATCCAGAGGCTCTAGCC
CAACTCCCAGGTGGTCCATTTTGGTCCATATTATTTTTTTTCATGCTTTTAACTTTGGGT
CTCGATTCTCAGTTTGCTTCGATTGAAACGATCACAACAACAATTCAAGATTTATTTCCC
AAAGTGATGAAGAAAATGAGGGTTCCCATAACTTTGGGCTGCTGCTTGGTTTTGTTTCTC
CTTGGTCTCGTCTGTGTGACTCAGGCTGGAATTTACTGGGTTCATCTGATTGACCACTTC
TGTGCTGGATGGGGCATTTTAATTGCAGCTATACTGGAGCTAGTTGGAATCATCTGGATT
TATGGAGGGAACAGATTCATTGAGGATACAGAAATGATGATTGGAGCAAAGAGGTGGATA
TTCTGGCTATGGTGGAGAGCTTGCTGGTTTGTAATTACGCCTATCCTTTTGATTGCAATA
TTTATCTGGTCATTGGTGCAATTTCATAGACCTAATTATGGCGCAATTCCATACCCTGAC
TGGGGAGTTGCTTTAGGCTGGTGTATGATTGTTTTCTGCATTATTTGGATACCAATTATG
GCTATCATAAAAATAATTCAGGCTAAAGGAAACATCTTTCAACGCCTTATAAGTTGCTGC
AGACCAGCTTCTAACTGGGGTCCATACCTGGAACAACATCGTGGGGAAAGATATAAAGAC
ATGGTAGATCCTAAAAAAGAGGCTGACCATGAAATACCTACTGTTAGTGGCAGCAGAAAA
CCGGAATGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
AF151978

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_6_Locus:
Xq23-q24

# Macromolecular_Interacting_Partner_6_SNPs:
rs12720074; rs2011162; rs5905179; rs12710570; rs5905289; rs2011198; rs2312055; rs2032525; rs5905176; rs5905284; rs7059155; rs2071877; rs4824325; rs10217924; rs5905178; rs6608646; rs12392462; rs2312057; rs12391221; rs17242824; rs5905288; rs12559530; rs10218102; rs10521579; rs12710569; rs10521578; rs5905285; rs5952101; rs12720080; rs12720088; rs5952099; rs12720083; rs5905177; rs4824358; rs4824324; rs12720076; rs4824359; rs12720084; rs12720079; rs5952103; rs2312056; rs12720089; rs17095419; rs12393509; rs4824323; rs2312054; rs7052454; rs12710568; rs12720073; rs12834312; rs3788766; rs5905283; rs12720085; rs28523889; rs6608648; rs11350870; rs34685017; rs28699570; rs12720092; rs28628632; rs12720078; rs5952174; rs35604008; rs5952104; rs5905287; rs6608645; rs12388847; rs10629819; rs12720087; rs12720091; rs35269408; rs17308739; rs3043424; rs35542990; rs5952100; rs5952102; rs35201069; rs6651554; rs12720077; rs10218234; rs6608647; rs12858125; rs34117081; rs5952175; rs12720082; rs34490652; rs4068397; rs7066547; rs7054956; rs12832551; rs10218418; rs12720075; rs12720086; rs12720090; rs35315031; rs7062559; rs10218017; rs12390279; rs12833869; rs12835480; rs12839137; rs12844003; rs17308697; rs2103697; rs2301451; rs5952181; rs6520234; rs6608511; rs6608514; rs6608644; rs6608650

# Macromolecular_Interacting_Partner_6_General_References:
10446133

# Macromolecular_Interacting_Partner_6_References:
Not Available

End of HMDB00168

Beginning of HMDB00169
# Accession_No:
HMDB00169

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-23 16:46:16

# biospider_lastupdate:
2007-04-18 12:46:27

# Common_Name:
D-Mannose

# Description:
D-Mannose is a carbohydrate. High-mannose-type oligosaccharides have been shown to play important roles in protein quality control. Several intracellular proteins, such as lectins, chaperones and glycan-processing enzymes, are involved in this process. These include calnexin/calreticulin, UDP-glucose:glycoprotein glucosyltransferase (UGGT), cargo receptors (such as VIP36 and ERGIC-53), mannosidase-like proteins (e.g. EDEM and Htm1p) and ubiquitin ligase (Fbs). They are thought to recognize high-mannose-type glycans with subtly different structures. Mannose-binding lectin (MBL) is an important constituent of the innate immune system. This protein binds through multiple lectin domains to the repeating sugar arrays that decorate many microbial surfaces, and is then able to activate the complement system through a specific protease called MBL-associated protease-2. The primary pathway for the formation of L-fucose in procaryotic and eucaryotic cells is from D-mannose via an internal oxidation reduction and then epimerization of GDP-D-mannose to produce GDP-L-fucose. (PMID: 9488699, 16154739, 11414367)


# Synonyms:
DL-mannose; (+)-mannose; D-Mannopyranose; Carubinose (van); D-mannose; (+-)-mannose; Mannose (van); D(+)-mannose;  nchembio828-comp8; Seminose; hexose (ACD/Name 4.0); Carubinose; Mannose

# Chemical_IUPAC_Name:
(3S,4S,5R,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol

# Chemical_Formula:
C6H12O6

# Chemical_Structure:
tbl_chemical:::HMDB00169_ZOOM.png:::119283231769145821

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00169_THUMB.png:::119283231610096371

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Carbohydrates

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiacetal; primary alcohol; secondary alcohol; 1,2-diol; heterocyclic compound

# Taxonomy_Biofunction:
Component of High-mannose type N-glycan biosynthesis; Component of N-Glycan biosynthesis

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
180.06339

# Molecular_Weight_Avg:
180.15588

# Smiles_String_isomeric:
OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O

# Smiles_String_canonical:
OCC1OC(O)C(O)C(O)C1O

# KEGG_Compound_ID:
C00159

# BioCyc_ID:
MANNOSE

# PubChem_CID:
18950

# PubChem_SID:
824809; 15322061; 3135279; 22396012; 8027205; 8164149; 789464; 15066909; 161919; 838927; 177344; 3459; 14720290

# OMIM_ID:
154545; 212065; 602579

# Metagene_ID:
Not Available

# BiGG_ID:
34085

# Wikipedia_ID:
D-Mannose

# METLIN_ID:
Not Available

# Ref_ID:
9812172; 3757018; 15994813; 1618483; 2322240; 8727793; 16339137; 1183043; 1991835; 14570881; 8779562; 12010488; 9842897; 16897182; 11286566; 9164956; 2625478; 8910412; 11455615; 16015045; 15788414; 2026685; 6421939; 15997205; 12872255; 3958133; 15995585; 15901736; 11427470; 9451038

# ChEBI_ID:
16024

# CAS_Registry_Number:
3458-28-4

# InChI:
InChI=1/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6?/m1/s1

# Synthesis_Reference:
Condensation of nitromethane with D- and L-arabinose: preparation of L-glucose and L-mannose.     Sowden, John C.; Fischer, Hermann O. L.    Univ. of Toronto,  Can.    Journal of the American Chemical Society  (1947),  69  1963-5.

# Melting_Point:
132 oC

# Melting_Point_predicted:
106.2 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
713.0 mg/mL at 17 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
782.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.57 [Predicted by ALOGPS]; -2.3 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::d-(+)-Mannose.pdf:::1132562210564199355

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::1176921985.mol:::190089090229684

# SDF_File_[Text]:
tbl_chemical:::HMDB00169.sdf:::119283231231085693

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00169.pdb:::119283231472543233

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041005_P00_05_HW_1DP_PRESAT_expanded_2.gif:::114460751535568613

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041005_P00_05_HW_1DP_presat.zip:::1177710564851868339

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041005_P00_05_HW_1DP_Assigned.png:::116553488211710407

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::041005_P00_05_HW_1DC_59.jpg:::114168476669637536

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041005_P00_05_HW_1DC_59.zip:::114168476666686567

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041005_P00_05_HW_1DC_59_Assigned.jpg:::116138034549715890

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041005_P00_05_HW_2DHSQC_189.jpg:::114539878066419193

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041005_P00_05_HW_2DHSQC_189.zip:::114539878067378591

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041005_P00_05_HW_2DHSQC_189_Assigned.jpg:::116138041546280486

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Mannose.gif:::1132732117390304687

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00169_peaks.txt:::1156309593826857871

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Mannose_C.gif:::1132737709642581160

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00169_peaks.txt:::1156310783345650155

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00169L.png:::117555262170679782; Medium Energy:tbl_ms:::HMDB00169M.png:::117555267266684778

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; endoplasmic reticulum; Extracellular; golgi apparatus; lysosome

# Tissue_Location:
Adrenal Medulla; Bladder; Epidermis; Fibroblasts; Intestine; Kidney; Muscle; Myelin; Pancreas; Placenta; Spleen; Testes; Testis

# deuterated:
No

# Biofluid_Location:
Blood; Breast Milk; CSF

# Concentration_[Normal]:
Blood	39.0 +/- 7.0	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	64.0 +/- 12.0	uM	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	64.0 (56.0-72.0)	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Breast_Milk	66.4 +/- 2.3	uM	Adult:>18_yrs_old	Female	Normal	16456418 


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Not Available

# Pathway_Names:
Glycolysis;Fructose and mannose metabolism;Galactose metabolism;Starch and sucrose metabolism;Streptomycin biosynthesis;Aminosugars metabolism;N-Glycan biosynthesis;Glycerolipid metabolism;Glycosphingolipid metabolism

# Pathway_Images:
Glycolysis.jpg;fructose_metabolism.jpg;;;;;;;

# KEGG_Images:
map00010;map00051;map00052;map00500;map00521;map00530;map00510;map00561;map00600

# Pathway_Graphs:
Glycolysis_Graph.jpg;fructose_metabolism_Graph.jpg;;;;;;;

# Pathway_SBMLs:
Glycolysis.xml;fructose_metabolism.xml;;;;;;;

# Metabolic_Enzyme_1_ID:
5445

# Metabolic_Enzyme_1_Name:
Hexokinase-2

# Metabolic_Enzyme_1_Synonyms:
Hexokinase type II; HK II; Muscle form hexokinase

# Metabolic_Enzyme_1_Gene_Name:
HK2

# Metabolic_Enzyme_1_Protein_Sequence:
>Hexokinase2
MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAA
VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMR
GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV
EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYME
EMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGM
YMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLG
LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKH
PHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLS
HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV
LLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF
TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG
TMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD
FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG
IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA
VVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKG
AALITAVACRIREAGQR

# Metabolic_Enzyme_1_Number_of_Residues:
917

# Metabolic_Enzyme_1_Molecular_Weight:
102381

# Metabolic_Enzyme_1_Theoretical_pI:
5.93

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_1_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism;
 map00521  Streptomycin biosynthesis;
 map00530  Aminosugars metabolism

# Metabolic_Enzyme_1_Reaction:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00349:Hexokinase_1;
PF03727:Hexokinase_2

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.7.1.1

# Metabolic_Enzyme_1_GenBank_ID_Protein:
587202

# Metabolic_Enzyme_1_SwissProt_ID:
HXK2_HUMAN (P52789)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
HK2

# Metabolic_Enzyme_1_Geneatlas_id:
HK2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4923

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding (By similarity)

# Metabolic_Enzyme_1_Gene_Sequence:
>2754 bp
ATGATTGCCTCGCATCTGCTTGCCTACTTCTTCACGGAGCTCAACCATGACCAAGTGCAG
AAGGTTGACCAGTATCTCTACCACATGCGCCTCTCTGATGAGACCCTCTTGGAGATCTCT
AAGCGGTTCCGCAAGGAGATGGAGAAAGGGCTTGGAGCCACCACTCACCCTACTGCAGCA
GTGAAGATGCTGCCCACCTTTGTGAGGTCCACTCCAGATGGGACAGAACACGGAGAGTTC
CTGGCTCTGGATCTTGGAGGGACCAACTTCCGTGTGCTTTGGGTGAAAGTAACGGACAAT
GGGCTCCAGAAGGTGGAGATGGAGAATCAGATCTATGCCATCCCTGAGGACATCATGCGA
GGCAGTGGCACCCAGCTGTTTGACCACATTGCCGAATGCCTGGCTAACTTCATGGATAAG
CTACAAATCAAAGACAAGAAGCTCCCACTGGGTTTTACCTTCTCGTTCCCCTGCCACCAG
ACTAAACTAGACGAGAGTTTCCTGGTCTCATGGACCAAGGGATTCAAGTCCAGTGGAGTG
GAAGGCAGAGACGTTGTGGCTCTGATCCGGAAGGCCATCCAGAGGAGAGGGGACTTTGAT
ATCGACATTGTGGCTGTGGTGAATGACACAGTTGGGACCATGATGACCTGTGGTTATGAT
GACCACAACTGTGAGATTGGTCTCATTGTGGGCACGGGCAGCAACGCCTGCTACATGGAA
GAGATGCGCCACATCGACATGGTGGAAGGCGATGAGGGGCGGATGTGTATCAATATGGAG
TGGGGGGCCTTCGGGGACGATGGCTCGCTCAACGACATTCGCACTGAGTTTGACCAGGAG
ATTGACATGGGCTCACTGAACCCGGGAAAGCAACTGTTTGAGAAGATGATCAGTGGGATG
TACATGGGGGAGCTGGTGAGGCTTATCCTGGTGAAGATGGCCAAGGAGGAGCTGCTCTTT
GGGGGGAAGCTCAGCCCAGAGCTTCTCAACACCGGTCGCTTTGAGACCAAAGACATCTCA
GACATTGAAGGGGAGAAGGATGGCATCCGGAAGGCCCGTGAGGTCCTGATGCGGTTGGGC
CTGGACCCGACTCAGGAGGACTGCGTGGCCACTCACCGGATCTGCCAGATCGTGTCCACA
CGCTCCGCCAGCCTGTGCGCAGCCACCCTGGCCGCCGTGCTGCAGCGCATCAAGGAGAAC
AAAGGCGAGGAGCGGCTGCGCTCTACTATTGGGGTCGACGGTTCCGTCTACAAGAAACAC
CCCCATTTTGCCAAGCGTCTACATAAGACCGTGCGGCGGCTGGTGCCCGGCTGCGATGTC
CGCTTCCTCCGCTCCGAGGATGGCAGTGGCAAAGGTGCAGCCATGGTGACAGCAGTGGCT
TACCGGCTGGCCGATCAACACCGTGCCCGCCAGAAGACATTAGAGCATCTGCAGCTGAGC
CATGACCAGCTGCTGGAGGTCAAGAGGAGGATGAAGGTAGAAATGGAGCGAGGTCTGAGC
AAGGAGACTCATGCCAGTGCCCCCGTCAAGATGCTGCCCACCTACGTGTGTGCTACCCCG
GACGGCACAGAGAAAGGGGACTTCTTGGCCTTGGACCTTGGAGGAACAAATTTCCGGGTC
CTGCTGGTCCGTGTTCGGAATGGGAAGTGGGGTGGAGTGGAGATGCACAACAAGATCTAC
GCCATCCCGCAGGAGGTCATGCACGGCACCGGGGACGAGCTCTTTGACCACATTGTCCAG
TGCATCGCGGACTTCCTCGAGTACATGGGCATGAAGGGCGTGTCCCTGCCTCTGGGTTTT
ACCTTCTCCTTCCCCTGCCAGCAGAACAGCCTGGACGAGAGCATCCTCCTCAAGTGGACA
AAAGGCTTCAAGGCATCTGGCTGCGAGGGCGAGGACGTGGTGACCCTGCTGAAGGAAGCG
ATCCACCGGCGAGAGGAGTTTGACCTGGATGTGGTTGCTGTGGTGAACGACACAGTCGGA
ACTATGATGACCTGTGGCTTTGAAGACCCTCACTGTGAAGTTGGCCTCATTGTTGGCACG
GGCAGCAATGCCTGCTACATGGAGGAGATGCGCAACGTGGAACTGGTGGAAGGAGAAGAG
GGGCGGATGTGTGTGAACATGGAATGGGGGGCCTTCGGGGACAATGGATGCCTAGATGAC
TTCCGCACAGAATTTGATGTGGCTGTGGATGAGCTTTCACTCAACCCCGGCAAGCAGAGG
TTCGAGAAAATGATCAGTGGAATGTACCTGGGTGAGATTGTCCGTAACATTCTCATCGAT
TTCACCAAGCGTGGACTACTCTTCCGAGGCCGCATCTCAGAGCGGCTCAAGACAAGGGGC
ATCTTTGAAACCAAGTTCTTGTCTCAGATTGAGAGTGACTGCCTGGCCCTGCTGCAAGTC
CGAGCCACCCTGCAACACTTAGGGCTTGAGAGCACCTGTGACGACAGCATCATTGTTAAG
GAGGTGTGCACTGTGGTGGCCCGGCGGGCAGCCCAGCTCTGTGGCGCAGGCATGGCCGCT
GTGGTGGACAGGATACGAGAAAACCGTGGGCTGGACGCTCTCAAAGTGACAGTGGGTGTG
GATGGGACCCTCTACAAGCTACATCCTCACTTTGCCAAAGTCATGCATGAGACAGTGAAG
GACCTGGCTCCGAAATGTGATGTGTCTTTCCTGCAGTCAGAGGATGGCAGCGGGAAGGGG
GCGGCGCTCATCACTGCTGTGGCCTGCCGCATCCGTGAGGCTGGACAGCGATAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
Z46376

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_1_Locus:
2p13

# Metabolic_Enzyme_1_SNPs:
rs2229629; rs3732299; rs28363029; rs28363015; rs2306808; rs2229626; rs10194657; rs2229622; rs28363033; rs28363014; rs943; rs656489; rs9679561; rs3832165; rs3732298; rs3732295; rs3821305; rs3732296; rs28363066; rs1061314; rs28384370; rs28362959; rs28363067; rs28384369; rs651071; rs2279429; rs1545522; rs681900; rs923273; rs1545523; rs1872837; rs3771755; rs4853066; rs1565064; rs3771782; rs3771772; rs3821307; rs11893422; rs680545; rs6732614; rs3771754; rs678350; rs11903758; rs11694331; rs694644; rs6754642; rs1032206; rs1869339; rs3771798; rs11688312; rs3771770; rs2171385; rs1487371; rs13395967; rs685363; rs6735303; rs3771781; rs4853069; rs3771752; rs6730141; rs2306806; rs3771756; rs4241264; rs10153633; rs3771771; rs3771763; rs3816456; rs17010492; rs11688305; rs13384240; rs3755454; rs3821310; rs11675401; rs2279428; rs6749471; rs10496195; rs28363012; rs3771751; rs3732300; rs28362967; rs4852347; rs3771786; rs3771759; rs3755453; rs6722578; rs4853067; rs28362977; rs3771768; rs3771773; rs28362973; rs3771783; rs3771760; rs3821309; rs1869340; rs4853064; rs3771758; rs3771769; rs11888976; rs3755452; rs2068358; rs10153634; rs17741356; rs3732301; rs4853068; rs3771753; rs6752205; rs11675438; rs4853065; rs6720940; rs2306805; rs3771790; rs3771766; rs17010467; rs28363062; rs13382443; rs3771761; rs28362980; rs28362969; rs3771775; rs10183051; rs3821311; rs3771762; rs604207; rs2123615; rs28362972; rs3755450; rs1807090; rs7602790; rs602898; rs634849; rs28363004; rs3771792; rs13394603; rs17010460; rs675611; rs28363048; rs28746193; rs28363047; rs28362983; rs28363042; rs28363035; rs28363055; rs28362999; rs28363003; rs3771788; rs28363044; rs3771793; rs5832141; rs28363060; rs28362996; rs3821308; rs11680091; rs2901626; rs3771778; rs11126442; rs28363053; rs28363021; rs17010436; rs28363011; rs11675530; rs28363054; rs28362979; rs28363008; rs28362968; rs6709975; rs28362997; rs13389855; rs28363032; rs2422043; rs17010464; rs842667; rs28363028; rs28362993; rs3078015; rs28362965; rs3755451; rs28363040; rs28362981; rs604112; rs3771784; rs28362964; rs13405909; rs663504; rs28363037; rs1565063; rs603743; rs6756096; rs13398307; rs28363027; rs28363049; rs13397480; rs11894886; rs17010504; rs28363031; rs28362987; rs28362990; rs4852348; rs28363023; rs3771767; rs2279427; rs3771785; rs28746191; rs680015; rs35902493; rs28362986; rs3771791; rs28363000; rs28363041; rs17847166; rs1386536; rs3821306; rs7572459; rs10496196; rs10496197; rs28363016; rs28363065; rs17847161; rs35677390; rs36066402; rs28363057; rs35396457; rs28363006; rs17847160; rs28363005; rs28363051; rs11556194; rs3202369; rs3732302; rs13429546; rs34573284; rs3832164; rs28384371; rs28362960; rs6741953; rs11556193; rs28384372; rs28384368; rs10451660; rs28362991; rs6755864; rs28363026; rs28363056; rs34315149; rs35716613; rs11689606; rs28363061; rs2029236; rs28362988; rs28363050; rs28363043; rs684491; rs28363034; rs2901627; rs11295383; rs5832143; rs618023; rs28362963; rs28362995; rs28363059; rs35137588; rs34780455; rs13432314; rs28363022; rs11450211; rs34286902; rs35601612; rs2422045; rs28362971; rs3771776; rs13395815; rs34063910; rs636903; rs28362978; rs6707123; rs5832142; rs6743207; rs35570397; rs13386610; rs676065; rs28362992; rs28363007; rs34662031; rs3836190; rs17847145; rs28362962; rs28363058; rs28363039; rs35888944; rs13387771; rs13004379; rs28362974; rs28362984; rs3836189; rs28362989; rs600578; rs35586432; rs28363064; rs10675736; rs6708938; rs17847149; rs35315423; rs10175889; rs28363019; rs3077985; rs35276905; rs28363036; rs35227945; rs3771787; rs35771648; rs7604247; rs2422046; rs3771774; rs11459447; rs28567425; rs35641789; rs11369279; rs6753090; rs28362961; rs11688513; rs11300678; rs28363018; rs10169547; rs28363024; rs34066885; rs6728248; rs7596751; rs28363010; rs28363002; rs36226712; rs28363052; rs34552028; rs2901628; rs28362976; rs3836188; rs28363046; rs7557784; rs17847165; rs35591732; rs28363063; rs28363020; rs28363025; rs28362985; rs28363009; rs34553329; rs35969102; rs28746192; rs7596131; rs10688878; rs35605685; rs2422044; rs34611487; rs28363017; rs3836187; rs28362982; rs17847158; rs36027258; rs5832144; rs28363001; rs34885061; rs41498345; rs28362994; rs34743801; rs34980367; rs636472; rs34106533; rs28969559; rs11308687; rs28363013; rs28363045; rs28363038; rs28362966; rs34842573; rs13020188; rs28362970; rs3771779; rs35454195; rs3771780; rs28746194; rs3771796; rs7600390; rs34021969; rs13411123; rs28362975; rs28362998; rs28363030; rs13013519; rs10865403; rs28384373; rs7424799; rs35575305; rs608112; rs659635; rs619850; rs3887287; rs35614058; rs35250889; rs10865404; rs11892954; rs12151815; rs1565068; rs17678046; rs17678088; rs2087173; rs2129603; rs34610149; rs4241265; rs4443023; rs4443024; rs4549114; rs4853059; rs5020284; rs628983; rs6546935; rs657209; rs670083; rs6730659; rs6758134; rs748357; rs7571422; rs7596427; rs7597871

# Metabolic_Enzyme_1_General_References:
8786021; 8250948; 7518342; 7883120; 7883122; 7883123

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6148

# Metabolic_Enzyme_2_Name:
Alpha-mannosidase IIx

# Metabolic_Enzyme_2_Synonyms:
Mannosyl-oligosaccharide 1,3- 1,6-alpha-mannosidase; MAN IIx; Mannosidase alpha class 2A member 2

# Metabolic_Enzyme_2_Gene_Name:
MAN2A2

# Metabolic_Enzyme_2_Protein_Sequence:
>Alphamannosidase IIx
MKLKKQVTVCGAAIFCVAVFSLYLMLDRVQHDPTRHQNGGNFPRSQISVLQNRIEQLEQL
LEENHEIISHIKDSVLELTANAEGPPAMLPYYTVNGSWVVPPEPRPSFFSISPQDCQFAL
GGRGQKPELQMLTVSEELPFDNVDGGVWRQGFDISYDPHDWDAEDLQVFVVPHSHNDPGW
IKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQKRAAVRRLVGN
GQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGATPRSGWAVDPFGYSSTMPYL
LRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTC
GPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLFRSNVLL
VPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQFGTLSDYFDALYKRTGVEPG
ARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHAR
RSGLAGRYPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVII
HAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDSSPRFVVLFNPLEQER
FSMVSLLVNSPRVRVLSEEGQPLAVQISAHWSSATEAVPDVYQVSVPVRLPALGLGVLQL
QLGLDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSDFALSNRYMQVWFSGLTGL
LKSIRRVDEEHEQQVDMQVLVYGTRTSKDKSGAYLFLPDGEASPTSPRSPPCCVSLKALS
SQRWLRTMSTFTRRSGFTICQGWRGCLWTYHPWWTSGTTSTRSWPCTSIQTSTARVQPRR
YLKKLPLQANFYPMPVMAYIQDAQKRLTLHTAQALGVSSLKDGQLEVILDRRLMQDDNRG
LGQGLKDNKRTCNRFRLLLERRTVGSEVQDSHSTSYPSLLSHLTSMYLNAPALALPVARM
QLPGPGLRSFHPLASSLPCDFHLLNLRTLQAEEDTLPSAETALILHRKGFDCGLEAKNLG
FNCTTSQGKVALGSLFHGLDVVFLQPTSLTLLYPLASPSNSTDVYLEPMEIATFRLRLG

# Metabolic_Enzyme_2_Number_of_Residues:
1139

# Metabolic_Enzyme_2_Molecular_Weight:
129284

# Metabolic_Enzyme_2_Theoretical_pI:
7.86

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  mannosidase activity
Function:  alpha-mannosidase activity
 ||
>>>
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  mannose metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway

# Metabolic_Enzyme_2_Pathway:
map00510  N-Glycan biosynthesis

# Metabolic_Enzyme_2_Reaction:
Hydrolysis of the terminal 1,3- and 1,6-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man5(GlcNAc)3

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF09261:Alpha-mann_mid;
PF01074:Glyco_hydro_38;
PF07748:Glyco_hydro_38C

# Metabolic_Enzyme_2_Signals:
1-31

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.2.1.114

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1132479

# Metabolic_Enzyme_2_SwissProt_ID:
MA2A2_HUMAN (P49641)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
MAN2A2

# Metabolic_Enzyme_2_Geneatlas_id:
MAN2A2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:6825

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_2_Gene_Sequence:
>3420 bp
ATGAAGCTGAAAAAGCAGGTGACAGTGTGTGGGGCTGCCATCTTCTGTGTGGCAGTCTTC
TCGCTCTACCTCATGCTGGACCGAGTGCAACACGATCCCACCCGACACCAGAATGGTGGG
AACTTCCCCCGGAGCCAAATTTCTGTGCTGCAGAACCGCATTGAGCAGCTGGAGCAGCTT
TTGGAGGAGAACCATGAGATTATCAGCCATATCAAGGACTCCGTGCTGGAGCTGACAGCC
AACGCAGAGGGCCCGCCCGCCATGCTGCCCTACTACACGGTCAATGGCTCCTGGGTGGTG
CCACCGGAGCCCCGGCCCAGCTTCTTCTCCATCTCCCCGCAGGACTGCCAGTTTGCTTTG
GGGGGCCGGGGTCAGAAGCCAGAGCTGCAGATGCTCACTGTGTCGGAGGAGCTGCCGTTT
GACAACGTGGATGGTGGTGTGTGGAGGCAAGGCTTCGACATCTCCTACGACCCGCACGAC
TGGGATGCTGAAGACCTGCAGGTGTTTGTGGTGCCCCACTCTCACAATGACCCAGGCTGG
ATCAAGACCTTTGACAAGTACTACACAGAGCAGACCCAACACATCCTCAATAGCATGGTG
TCTAAGCTGCAGGAGGACCCCCGGCGGCGCTTCCTCTGGGCAGAGGTCTCCTTCTTCGCC
AAGTGGTGGGACAACATCAATGTCCAAAAGAGAGCGGCAGTCCGAAGGCTGGTGGGAAAC
GGGCAGCTGGAGATTGCGACAGGAGGCTGGGTGATGCCAGATGAGGCCAATTCCCACTAC
TTTGCATTGATTGACCAGCTCATCGAAGGACACCAGTGGCTGGAGAGAAATCTTGGTGCA
ACCCCCCGCTCTGGCTGGGCAGTGGACCCCTTTGGATACAGCTCCACCATGCCTTACCTG
CTGCGCCGTGCCAACCTCACCAGCATGCTGATTCAGAGAGTGCACTATGCCATCAAGAAG
CACTTTGCTGCCACCCACAGCCTAGAGTTCATGTGGAGGCAGACATGGGACTCGGACTCC
AGCACAGACATCTTCTGTCACATGATGCCCTTCTACAGCTATGACGTCCCCCATACCTGT
GGCCCAGATCCCAAGATCTGCTGCCAATTTGATTTCAAACGCCTGCCTGGTGGGCGCATC
AACTGCCCTTGGAAGGTGCCACCCCGGGCCATCACAGAGGCCAACGTGGCAGAGAGGGCA
GCCCTGCTTCTGGACCAATACCGGAAGAAGTCCCAGCTGTTCCGAAGCAACGTCCTCCTG
GTGCCTCTTGGAGATGACTTCCGATATGACAAGCCCCAGGAGTGGGATGCCCAGTTCTTC
AACTACCAACGGCTCTTTGACTTCTTCAACAGCAGGCCTAACCTCCATGTGCAGGCCCAG
TTTGGCACTCTTTCTGACTATTTTGATGCCCTGTACAAGAGGACAGGGGTGGAGCCAGGG
GCCCGGCCTCCAGGGTTTCCTGTGCTGAGCGGGGATTTCTTCTCCTATGCGGACCGGGAG
GATCATTACTGGACAGGCTATTACACTTCCCGGCCCTTCTACAAGAGCTTAGACCGAGTC
CTGGAAGCCCACCTGCGGGGGGCAGAGGTTCTGTACAGCCTGGCTGCAGCTCACGCTCGC
CGCTCTGGTCTGGCTGGCCGGTACCCACTGTCTGATTTCACCCTCCTGACGGAAGCTCGG
CGCACATTGGGGCTCTTCCAGCATCACGATGCCATCACTGGCACGGCCAAGGAGGCTGTG
GTGGTGGACTATGGGGTCAGGCTTCTGCGCTCCCTTGTCAACCTGAAGCAGGTCATCATT
CATGCAGCCCACTATCTGGTGCTGGGGGACAAGGAGACCTACCACTTTGACCCTGAGGCG
CCCTTCCTCCAAGTGGATGACACTCGCTTAAGTCACGACGCCCTCCCAGAGCGCACGGTG
ATCCAGCTGGATTCCTCGCCCAGGTTTGTGGTCCTATTCAACCCACTGGAACAGGAGCGA
TTCAGCATGGTGTCCCTGCTGGTCAACTCTCCCCGCGTGCGTGTCCTTTCGGAGGAGGGT
CAGCCCCTGGCCGTGCAGATCAGCGCACACTGGAGCTCTGCCACCGAGGCGGTCCCTGAC
GTCTACCAGGTGTCTGTGCCTGTCCGCCTGCCAGCCCTGGGCCTGGGCGTGCTGCAGCTA
CAGCTGGGCCTGGATGGGCACCGCACGCTGCCCTCCTCTGTGCGCATCTACCTGCACGGC
CGGCAGCTGTCCGTCAGCAGGCACGAAGCGTTTCCTCTCCGTGTCATTGACTCTGGCACC
AGCGACTTCGCCCTCAGCAACCGCTACATGCAGGTCTGGTTCTCAGGCCTTACTGGGCTC
CTCAAGAGCATCCGAAGGGTGGATGAGGAGCACGAGCAGCAGGTGGACATGCAGGTCCTT
GTCTATGGCACCCGTACGTCCAAAGACAAGAGTGGAGCCTACCTCTTCCTGCCCGATGGC
GAGGCAAGCCCTACGTCCCCAAGGAGCCCCCCGTGCTGCGTGTCACTGAAGGCCCTTTCT
TCTCAGAGGTGGTTGCGTACTATGAGCACATTCACCAGGCGGTCCGGCTTTACAATCTGC
CAGGGGTGGAGGGGCTGTCTCTGGACATATCATCCCTGGTGGACATCCGGGACTACGTCA
ACAAGGAGCTGGCCCTGCACATCCATACAGACATCGACAGCCAGGGTGCAGCCCCGACGG
TATCTGAAGAAGCTCCCCCTCCAGGCCAACTTCTACCCCATGCCAGTCATGGCCTATATC
CAGGACGCACAGAAGCGCCTCACGCTGCACACTGCCCAGGCCCTGGGTGTCTCTAGCCTC
AAAGATGGCCAGCTGGAGGTGATCTTGGACCGGCGGCTGATGCAGGATGACAACCGGGGC
CTAGGCCAAGGGCTCAAGGACAACAAGAGAACCTGCAACCGTTTCCGCCTCCTGCTAGAG
CGGCGAACCGTGGGCAGTGAGGTCCAAGATAGCCACTCTACCAGCTACCCATCCCTCCTC
AGCCACCTGACCTCCATGTACCTGAACGCCCCGGCGCTCGCTCTGCCTGTAGCCAGGATG
CAGCTCCCAGGCCCTGGTCTGCGCTCATTTCATCCTCTGGCTTCCTCACTGCCCTGTGAC
TTCCACCTGCTCAACCTACGTACGCTCCAGGCTGAGGAGGACACCCTACCCTCGGCGGAG
ACCGCACTCATCTTACACCGCAAGGGTTTTGACTGCGGCCTGGAGGCCAAGAACTTGGGC
TTCAACTGCACCACAAGCCAAGGCAAGGTAGCCCTGGGCAGCCTTTTCCATGGCCTGGAT
GTGGTATTCCTTCAGCCAACCTCCTTGACGTTACTGTACCCTCTGGCCTCCCCGTCCAAC
AGCACTGACGTCTATTTGGAGCCCATGGAGATTGCTACCTTTCGCCTCCGCTTGGGTTAG


# Metabolic_Enzyme_2_GenBank_ID_Gene:
D55649

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_2_Locus:
15q26.1

# Metabolic_Enzyme_2_SNPs:
rs2106673; rs12909056; rs1266494; rs2072077; rs12442020; rs12594307; rs2677750; rs1266481; rs1266482; rs8033977; rs10048033; rs1059891; rs4773; rs1266479; rs1266490; rs1266489; rs1266483; rs1266488; rs7183098; rs2072078; rs2239293; rs1266484; rs1266495; rs4932377; rs2238340; rs2009105; rs6496737; rs1266485; rs3784779; rs1057105; rs2677748; rs17635872; rs4932180; rs2002739; rs7184022; rs2238339; rs12439805; rs11854230; rs7164275; rs13329129; rs17593311; rs8032127; rs1978113; rs2239294; rs2677744; rs1266486; rs2677749; rs1266492; rs2677745; rs2677746; rs12591833; rs877285; rs734252; rs35831960; rs28446956; rs1266491; rs2677743; rs2074057; rs34171711; rs35395194; rs11544524; rs41470046; rs1803097; rs34970738; rs1266480; rs41515554; rs2677747; rs35005235; rs13329429; rs35678748; rs11630752; rs12915571; rs34141725; rs11857741; rs34493587; rs35871165; rs28622439; rs35673743; rs28690870; rs28421369; rs7180660; rs35228338; rs756977; rs10580344; rs1266487; rs11630484; rs35245127; rs28625852; rs35658196; rs34142958; rs35041477; rs1978112; rs7163962; rs11459251; rs34215683; rs11073958; rs10532338; rs1266493; rs35968052; rs34585509; rs886209; rs2677742; rs2521494; rs12440177; rs2521497; rs28362509; rs34381607; rs28446644; rs2521496; rs2677741; rs34663407; rs2521495; rs1029419; rs1029420; rs1052528; rs1052532; rs1052535; rs11853870; rs12904457; rs13252; rs2521498; rs2521500; rs2677737; rs2677738; rs2677739; rs34967259; rs7173069; rs8026356; rs8035950

# Metabolic_Enzyme_2_General_References:
8524845

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6149

# Metabolic_Enzyme_3_Name:
Alpha-mannosidase 2

# Metabolic_Enzyme_3_Synonyms:
Alpha-mannosidase II; Mannosyl- oligosaccharide 1,3-1,6-alpha-mannosidase; MAN II; Golgi alpha- mannosidase II; Mannosidase alpha class 2A member 1

# Metabolic_Enzyme_3_Gene_Name:
MAN2A1

# Metabolic_Enzyme_3_Protein_Sequence:
>Alphamannosidase 2
MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLER
LLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFAS
QSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGW
LKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIEN
GQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYL
LNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTC
GPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLL
APLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRD
KGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAH
KYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIG
NSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDR
ISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKI
LESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMT
KEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTC
FFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQ
IQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQ
DDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPM
ANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCRFS
SKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFR
IQLR

# Metabolic_Enzyme_3_Number_of_Residues:
1144

# Metabolic_Enzyme_3_Molecular_Weight:
131142

# Metabolic_Enzyme_3_Theoretical_pI:
7.61

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  mannosidase activity
Function:  alpha-mannosidase activity
 ||
>>>
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  mannose metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway

# Metabolic_Enzyme_3_Pathway:
map00510  N-Glycan biosynthesis

# Metabolic_Enzyme_3_Reaction:
Hydrolysis of the terminal 1,3- and 1,6-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man5(GlcNAc)3

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF09261:Alpha-mann_mid;
PF01074:Glyco_hydro_38;
PF07748:Glyco_hydro_38C

# Metabolic_Enzyme_3_Signals:
1-31

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.2.1.114

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1117827

# Metabolic_Enzyme_3_SwissProt_ID:
MA2A1_HUMAN (Q16706)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
MAN2A1

# Metabolic_Enzyme_3_Geneatlas_id:
MAN2A1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:6824

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_3_Gene_Sequence:
>3435 bp
ATGAAGTTAAGCCGCCAGTTCACCGTGTTCGGCAGTGCGATCTTCTGTGTGGTGATTTTC
TCGCTCTACCTGATGCTGGACCGGGGTCACTTAGACTACCCCAGGAACCCGCGCCGCGAG
GGCTCCTTCCCTCAGGGCCAGCTCTCAATGTTGCAAGAAAAAATAGACCATTTGGAGCGT
TTGCTAGCTGAGAATAATGAGATCATCTCAAATATTAGAGACTCAGTCATCAATTTGAGT
GAGTCTGTGGAGGATGGTCCGAAAAGTTCACAAAGCAATTTCAGCCAAGGTGCTGGCTCA
CATCTTCTGCCCTCACAATTATCCCTCTCAGTTGACACTGCAGACTGTCTGTTTGCTTCA
CAAAGTGGAAGTCACAATTCAGATGTGCAGATGTTGGATGTTTACAGTCTAATTTCTTTT
GACAATCCAGATGGTGGAGTTTGGAAGCAAGGATTTGACATTACTTATGAATCTAATGAA
TGGGACACTGAACCCCTTCAAGTCTTTGTGGTGCCTCATTCCCATAACGACCCAGGTTGG
TTGAAGACTTTCAATGACTACTTTAGAGACAAGACTCAGTATATTTTTAATAACATGGTC
CTAAAGCTGAAAGAAGACTCACGGAGGAAGTTTATTTGGTCTGAGATCTCTTACCTTTCA
AAGTGGTGGGATATTATAGATATTCAGAAGAAGGATGCTGTTAAAAGTTTAATAGAAAAT
GGTCAGCTTGAAATTGTGACAGGTGGCTGGGTTATGCCTGATGAAGCTACTCCACATTAT
TTTGCCTTAATTGATCAACTAATTGAAGGACATCAGTGGCTGGAAAATAATATAGGAGTG
AAACCTCGGTCCGGCTGGGCTATTGATCCCTTTGGACACTCACCAACAATGGCTTATCTT
CTAAACCGTGCTGGACTTTCTCACATGCTTATCCAGAGAGTTCATTATGCAGTTAAAAAA
CACTTTGCACTGCATAAAACATTGGAGTTTTTTTGGAGACAGAATTGGGATCTGGGATCT
GTCACAGATATTTTATGCCACATGATGCCCTTCTACAGCTATGACATCCCTCACACTTGT
GGACCTGATCCTAAAATATGCTGCCAGTTTGATTTTAAACGTCTTCCTGGAGGCAGATTT
GGTTGTCCCTGGGGAGTCCCCCCAGAAACAATACATCCTGGAAATGTCCAAAGCAGGGCT
CGGATGCTACTAGATCAGTACCGAAAGAAGTCAAAGCTTTTTCGAACCAAAGTTCTCCTG
GCTCCACTAGGAGATGATTTCCGCTACTGTGAATACACGGAATGGGATTTACAGTTTAAG
AATTATCAGCAGCTTTTTGATTATATGAATTCTCAGTCCAAGTTTAAAGTTAAGATACAG
TTTGGAACTTTATCAGATTTTTTTGATGCGCTGGATAAAGCAGATGAAACTCAGAGAGAC
AAGGGCCAATCGATGTTCCCTGTTTTAAGTGGAGATTTTTTCACTTATGCCGATCGAGAT
GATCATTACTGGAGTGGCTATTTTACATCCAGACCCTTTTACAAACGAATGGACAGAATC
ATGGAATCTCATTTAAGGGCTGCTGAAATTCTTTACTATTTCGCCCTGAGACAAGCTCAC
AAATACAAGATAAATAAATTTCTCTCATCATCACTTTACACGGCACTGACAGAAGCCAGA
AGGAATTTGGGACTGTTTCAACATCATGATGCTATCACAGGAACTGCAAAAGACTGGGTG
GTTGTGGATTATGGTACCAGACTTTTTCATTCGTTAATGGTTTTGGAGAAGATAATTGGA
AATTCTGCATTTCTTCTTATTGGGAAGGACAAACTCACATACGACTCTTACTCTCCTGAT
ACCTTCCTGGAGATGGATTTGAAACAAAAATCACAAGATTCTCTGCCACAAAAAAATATA
ATAAGGCTGAGTGCGGAGCCAAGGTACCTTGTGGTCTATAATCCTTTAGAACAAGACCGA
ATCTCGTTGGTCTCAGTCTATGTGAGTTCCCCGACAGTGCAAGTGTTCTCTGCTTCAGGA
AAACCTGTGGAAGTTCAAGTCAGCGCAGTTTGGGATACAGCAAATACTATTTCAGAAACA
GCCTATGAGATCTCTTTTCGAGCACATATACCGCCATTGGGACTGAAAGTGTATAAGATT
TTGGAATCAGCAAGTTCAAATTCACATTTAGCTGATTATGTCTTGTATAAGAATAAAGTA
GAAGATAGCGGAATTTTCACCATAAAGAATATGATAAATACTGAAGAAGGTATAACACTA
GAGAACTCCTTTGTTTTACTTCGGTTTGATCAAACTGGACTTATGAAGCAAATGATGACT
AAAGAAGATGGTAAACACCATGAAGTAAATGTGCAATTTTCATGGTATGGAACCACAATT
AAAAGAGACAAAAGTGGTGCCTACCTCTTCTTACCTGATGGTAATGCCAAGCCTTATGTT
TACACAACACCGCCCTTTGTCAGAGTGACACATGGAAGGATTTATTCGGAAGTGACTTGC
TTTTTTGACCATGTTACTCATAGAGTCCGACTATACCACATACAGGGAATAGAAGGACAG
TCTGTGGAAGTTTCCAATATTGTGGACATCCGAAAAGTATATAACCGTGAGATTGCAATG
AAAATTTCTTCTGATATAAAAAGCCAAAATAGATTTTATACTGACCTAAATGGGTACCAG
ATTCAACCTAGAATGACACTGAGCAAATTGCCTCTTCAAGCAAATGTCTATCCCATGACC
ACAATGGCCTATATCCAGGATGCCAAACATCGTTTGACACTGCTCTCTGCTCAGTCATTA
GGGGTTTCGAGTTTGAATAGTGGTCAGATTGAAGTTATCATGGATCGAAGACTCATGCAA
GATGATAATCGTGGCCTTGAGCAAGGTATCCAGGATAACAAGATTACAGCTAATCTATTT
CGAATACTACTAGAAAAAAGAAGTGCTGTTAATACGGAAGAAGAAAAGAAGTCGGTCAGT
TATCCTTCTCTCCTTAGCCACATAACTTCTTCTCTCATGAATCATCCAGTCATTCCAATG
GCAAATAAGTTCTCCTCACCTACCCTTGAGCTGCAAGGTGAATTCTCTCCATTACAGTCA
TCTTTGCCTTGTGACATTCATCTGGTTAATTTGAGAACAATACAGTCAAAGGTGGGCAAT
GGGCACTCCAATGAGGCAGCCTTGATCCTCCACAGAAAAGGGTTTGATTGTCGGTTCTCT
AGCAAAGGCACAGGGCTGTTTTGTTCTACTACTCAGGGAAAGATATTGGTACAGAAACTT
TTAAACAAGTTTATTGTCGAAAGTCTCACACCTTCATCACTATCCTTGATGCATTCACCT
CCCGGCACTCAGAATATAAGTGAGATCAACTTGAGTCCAATGGAAATCAGCACATTCCGA
ATCCAGTTGAGGTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U31520

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_3_Locus:
5q21-q22

# Metabolic_Enzyme_3_SNPs:
rs6894260; rs13189822; rs3186988; rs4957836; rs1047004; rs724784; rs1015975; rs2416219; rs958235; rs2043831; rs1866372; rs2416222; rs2042165; rs2112212; rs961663; rs2301004; rs2284987; rs2042167; rs2010665; rs1015976; rs1866373; rs719088; rs724214; rs1432805; rs2013884; rs1019446; rs952826; rs2301006; rs2010653; rs1368357; rs1370958; rs2301016; rs6594396; rs7716761; rs6863999; rs2269198; rs2300992; rs1370960; rs11241032; rs2007136; rs7729249; rs2301000; rs2269203; rs6866335; rs13171456; rs10072119; rs7724365; rs2269207; rs6594403; rs11960588; rs763662; rs11241039; rs7737286; rs3797689; rs6880336; rs11741566; rs11959189; rs7700520; rs10039083; rs2218071; rs6898382; rs6887270; rs3797693; rs10063830; rs11960226; rs2269208; rs6877440; rs12656073; rs2300991; rs3797681; rs2269206; rs724783; rs6877418; rs1438660; rs6866317; rs6875086; rs3756598; rs2300999; rs3797699; rs1008661; rs11747338; rs2301010; rs3797672; rs2042164; rs10078710; rs2269197; rs1370959; rs6872974; rs2301013; rs2284990; rs11948599; rs4388249; rs2301001; rs3797680; rs2269204; rs4569915; rs3756599; rs4957577; rs10038829; rs1438663; rs2193949; rs10057295; rs11744587; rs2269210; rs4406176; rs11745926; rs10051841; rs2249413; rs13355415; rs10059767; rs3797698; rs2300998; rs4957580; rs10065099; rs12656571; rs12656763; rs6865201; rs759811; rs7725487; rs6894052; rs2217639; rs11241042; rs17162298; rs929749; rs3797674; rs12514321; rs2216556; rs1438661; rs2300997; rs13175917; rs1111213; rs11241029; rs10040716; rs9326781; rs11746187; rs2013881; rs2301003; rs7711326; rs2301012; rs11953031; rs12652404; rs9326783; rs2301015; rs1005665; rs17162263; rs10070011; rs17162347; rs10066423; rs2042166; rs10491358; rs11958393; rs6594395; rs10452541; rs10477446; rs3756597; rs248751; rs723350; rs17162261; rs10491357; rs2068964; rs3776932; rs6876585; rs17638690; rs11949519; rs11958160; rs17489649; rs6897334; rs2301011; rs1015974; rs2015698; rs2284991; rs10075520; rs17162307; rs17162308; rs10055229; rs12654396; rs17162094; rs3797694; rs3797686; rs6867752; rs2301014; rs9326784; rs11740629; rs11241030; rs3797676; rs2284989; rs6594401; rs11746945; rs3797696; rs10515405; rs7728733; rs10491356; rs3797688; rs6878693; rs2300989; rs13355543; rs1432806; rs2269211; rs2301017; rs13436015; rs10039366; rs11241040; rs2269205; rs13157374; rs2161123; rs1981815; rs3797685; rs6868615; rs6594398; rs11750336; rs11738247; rs17162326; rs6594402; rs759809; rs2216555; rs13180410; rs17162179; rs13172735; rs9326780; rs7726501; rs11948554; rs2284988; rs6869581; rs3797684; rs10040319; rs12656748; rs3776933; rs2269201; rs1368356; rs7710031; rs6881643; rs6880826; rs13153918; rs17162341; rs11750404; rs6594397; rs10463601; rs3797683; rs6897826; rs9716397; rs17162350; rs2301009; rs11949443; rs17162099; rs4957833; rs17162128; rs12656712; rs17162338; rs7726985; rs12517006; rs17162215; rs1124946; rs4321784; rs10041575; rs2416221; rs2300993; rs17162095; rs2112213; rs12518625; rs3797690; rs7726343; rs10900658; rs17162241; rs6878323; rs12189512; rs17163950; rs17450979; rs9716136; rs11241041; rs3797670; rs2269209; rs6891958; rs17488820; rs2301008; rs12515362; rs17162081; rs13178260; rs10054111; rs12187123; rs17162235; rs10223076; rs17638392; rs12659932; rs12520726; rs17162093; rs3797697; rs12374452; rs2416218; rs2300996; rs12652644; rs6886389; rs6889401; rs17162129; rs6892181; rs11951291; rs11950312; rs3819904; rs6870652; rs2300995; rs12519608; rs3797673; rs10477974; rs3839282; rs17424079; rs3216684; rs7719183; rs17162317; rs11241036; rs13187428; rs17162274; rs999582; rs13187248; rs4141494; rs4957578; rs6868564; rs13180361; rs10071320; rs9716414; rs2301002; rs3753175; rs6897420; rs17423051; rs10036979; rs2300994; rs17162169; rs9763895; rs6878396; rs17162109; rs17162238; rs12109742; rs6877790; rs9764072; rs4957579; rs17162344; rs17162087; rs11952363; rs10067856; rs2269202; rs11241037; rs1368358; rs10069314; rs2416217; rs3797677; rs3797692; rs10072086; rs3753174; rs13164109; rs17162097; rs759812; rs17162113; rs4527652; rs2269199; rs6882315; rs11958013; rs2300988; rs4141495; rs10477975; rs17162244; rs3753176; rs17422574; rs17162108; rs6871227; rs17162279; rs2077221; rs17162272; rs10037817; rs3831885; rs12656080; rs7722057; rs10055921; rs17162292; rs11241038; rs17162096; rs4352640; rs2301005; rs6897830; rs10065579; rs17162103; rs759810; rs12518635; rs10035167; rs845734; rs2241693; rs845735; rs12659765; rs1438662; rs17839482; rs845733; rs17839483; rs11351742; rs41296553; rs2300987; rs33993965; rs11475920; rs28435628; rs248753; rs10561129; rs35395897; rs4392673; rs1561397; rs35796131; rs34509465; rs34387996; rs34486067; rs28413537; rs11952151; rs28567942; rs6881801; rs41296545; rs35497601; rs13170901; rs35361925; rs12163990; rs3065546; rs10477978; rs12656720; rs12188708; rs35995072; rs6893386; rs5870393; rs28712484; rs34371572; rs34752339; rs7711461; rs34409956; rs3797679; rs10463428; rs13436620; rs6862458; rs2241353; rs35680097; rs11953342; rs34395538; rs13163089; rs34820879; rs7735240; rs13168231; rs12653940; rs13185070; rs10065722; rs36021634; rs5870388; rs36116953; rs248750; rs34186323; rs34659577; rs35215112; rs11445370; rs35578490; rs36077600; rs7707815; rs34120805; rs34895097; rs34955275; rs34821252; rs34623582; rs10652843; rs34942040; rs11742677; rs34813957; rs36093970; rs34884306; rs5870392; rs34364676; rs35780207; rs7736319; rs35057292; rs35571675; rs35078711; rs3797695; rs3797687; rs2269200; rs9686908; rs1561396; rs35068284; rs35865108; rs34307566; rs35160568; rs10655058; rs11744713; rs34097054; rs7447186; rs10561128; rs10073930; rs35915183; rs13181640; rs3839281; rs35601343; rs35929944; rs35780808; rs13162817; rs33934833; rs13161803; rs35101096; rs34706233; rs28756687; rs34748595; rs13181761; rs35761218; rs13168074; rs35682515; rs34407331; rs10477977; rs11343270; rs35780891; rs34485780; rs4141493; rs6897383; rs35229021; rs10682906; rs11449665; rs35854900; rs11420396; rs724215; rs3985090; rs11958733; rs28446907; rs35308996; rs35048740; rs35148698; rs41296549; rs34492008; rs35427592; rs35322641; rs13179311; rs6873160; rs36071762; rs10060050; rs11306329; rs35163115; rs10559573; rs34255307; rs3985091; rs11954593; rs34536116; rs11422443; rs10041721; rs7708153; rs3797678; rs34837720; rs4551129; rs12374548; rs13170889; rs4473809; rs11367898; rs35262974; rs13177811; rs34033611; rs35547924; rs34625389; rs5870385; rs34189691; rs3985094; rs10605318; rs3842054; rs35941934; rs34078958; rs35241108; rs10657736; rs35945232; rs1076510; rs3985093; rs33911767; rs34725929; rs13162818; rs13162850; rs35865336; rs35164284; rs35245662; rs2300990; rs12187114; rs11748714; rs34961375; rs35576739; rs5870389; rs35620224; rs6866744; rs3831884; rs10072541; rs3839280; rs41296547; rs35956487; rs35169875; rs34419147; rs248752; rs11958796; rs36133929; rs3985089; rs35613493; rs35861679; rs28733449; rs6866353; rs13164441; rs35342188; rs35788147; rs11956293; rs9326782; rs34188816; rs3962826; rs1047009; rs28672263; rs34052755; rs34354115; rs7710541; rs2112215; rs35950538; rs34685998; rs10223197; rs13187793; rs11316666; rs35165839; rs13362434; rs34437117; rs5870386; rs34595717; rs7447112; rs35521465; rs6871664; rs35671906; rs34988402; rs10078198; rs6891855; rs11418784; rs5870390; rs35415463; rs34026574; rs11315259; rs7712573; rs34887053; rs34822382; rs35551171; rs13162845; rs3985092; rs1060473; rs34780029; rs4377746; rs41296551; rs10602185; rs3216685; rs34198116; rs33955574; rs35164357; rs11241031; rs34107287; rs11741294; rs11420661; rs35325197; rs10713345; rs34830906; rs1370957; rs10477444; rs17162233; rs12109133; rs11279837; rs11298846; rs34011096; rs13179701; rs36150154; rs3839283; rs248749; rs34048618; rs13179289; rs35491014; rs5870387; rs10056314; rs13161652; rs34610579; rs35901259; rs11410281; rs2112214; rs12186794; rs34610770; rs3797671; rs35965772; rs12653938; rs13161469; rs35898281; rs12655571; rs10524185; rs35722707; rs34067484; rs34749176; rs34408577; rs34417962; rs35619778; rs33984925; rs34398256; rs12374566; rs10544972; rs12657204; rs34247538; rs12386477; rs5870391; rs35576052; rs34221928; rs35437330; rs41295843; rs10060778; rs34340777; rs34191404; rs2161124; rs4429893; rs3797691; rs13189002; rs13189235; rs34995311; rs1061729; rs35272361; rs34682541; rs10069890; rs1038782; rs10491355; rs1121669; rs11743686; rs11948246; rs11955234; rs11956236; rs12654058; rs12654807; rs12656279; rs12658214; rs13167652; rs13356253; rs13359388; rs17162065; rs17162390; rs17425291; rs17450784; rs2053047; rs2241690; rs2241691; rs2241692; rs2301007; rs253242; rs2671; rs3563; rs402618; rs4493713; rs577391; rs6881892; rs6891451; rs7711982; rs845737; rs845738; rs845739; rs845740; rs9326785; rs9326786

# Metabolic_Enzyme_3_General_References:
8524845

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5442

# Metabolic_Enzyme_4_Name:
Glucokinase

# Metabolic_Enzyme_4_Synonyms:
Hexokinase-4; Hexokinase type IV; HK IV; HK4; Hexokinase-D

# Metabolic_Enzyme_4_Gene_Name:
GCK

# Metabolic_Enzyme_4_Protein_Sequence:
>Glucokinase
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ

# Metabolic_Enzyme_4_Number_of_Residues:
465

# Metabolic_Enzyme_4_Molecular_Weight:
52192

# Metabolic_Enzyme_4_Theoretical_pI:
4.85

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage

# Metabolic_Enzyme_4_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism;
 map00521  Streptomycin biosynthesis

# Metabolic_Enzyme_4_Reaction:
ATP + D-glucose = ADP + D-glucose 6-phosphate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00349:Hexokinase_1;
PF03727:Hexokinase_2

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.7.1.2

# Metabolic_Enzyme_4_GenBank_ID_Protein:
179427

# Metabolic_Enzyme_4_SwissProt_ID:
HXK4_HUMAN (P35557)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
GCK

# Metabolic_Enzyme_4_Geneatlas_id:
GCK

# Metabolic_Enzyme_4_hgnc_id:
HGNC:4195

# Metabolic_Enzyme_4_PDB_ID:
1V4T

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>1398 bp
ATGCTGGACGACAGAGCCAGGATGGAGGCCGCCAAGAAGGAGAAGGTAGAGCAGATCCTG
GCAGAGTTCCAGCTGCAGGAGGAGGACCTGAAGAAGGTGATGAGACGGATGCAGAAGGAG
ATGGACCGCGGCCTGAGGCTGGAGACCCATGAAGAGGCCAGTGTGAAGATGCTGCCCACC
TACGTGCGCTCCACCCCAGAAGGCTCAGAAGTCGGGGACTTCCTCTCCCTGGACCTGGGT
GGCACTAACTTCAGGGTGATGCTGGTGAAGGTGGGAGAAGGTGAGGAGGGGCAGTGGAGC
GTGAAGACCAAACACCAGATGTACTCCATCCCCGAGGACGCCATGACCGGCACTGCTGAG
ATGCTCTTCGACTACATCTCTGAGTGCATCTCCGACTTCCTGGACAAGCATCAGATGAAA
CACAAGAAGCTGCCCCTGGGCTTCACCTTCTCCTTTCCTGTGAGGCACGAAGACATCGAT
AAGGGCATCCTTCTCAACTGGACCAAGGGCTTCAAGGCCTCAGGAGCAGAAGGGAACAAT
GTCGTGGGGCTTCTGCGAGACGCTATCAAACGGAGAGGGGACTTTGAAATGGATGTGGTG
GCAATGGTGAATGACACGGTGGCCACGATGATCTCCTGCTACTACGAAGACCATCAGTGC
GAGGTCGGCATGATCGTGGGCACGGGCTGCAATGCCTGCTACATGGAGGAGATGCAGAAT
GTGGAGCTGGTGGAGGGGGACGAGGGCCGCATGTGCGTCAATACCGAGTGGGGCGCCTTC
GGGGACTCCGGCGAGCTGGACGAGTTCCTGCTGGAGTATGACCGCCTGGTGGACGAGAGC
TCTGCAAACCCCGGTCAGCAGCTGTATGAGAAGCTCATAGGTGGCAAGTACATGGGCGAG
CTGGTGCGGCTTGTGCTGCTCAGGCTCGTGGACGAAAACCTGCTCTTCCACGGGGAGGCC
TCCGAGCAGCTGCGCACACGCGGAGCCTTCGAGACGCGCTTCGTGTCGCAGGTGGAGAGC
GACACGGGCGACCGCAAGCAGATCTACAACATCCTGAGCACGCTGGGGCTGCGACCCTCG
ACCACCGACTGCGACATCGTGCGCCGCGCCTGCGAGAGCGTGTCTACGCGCGCTGCGCAC
ATGTGCTCGGCGGGGCTGGCGGGCGTCATCAACCGCATGCGCGAGAGCCGCAGCGAGGAC
GTAATGCGCATCACTGTGGGCGTGGATGGCTCCGTGTACAAGCTGCACCCCAGCTTCAAG
GAGCGGTTCCATGCCAGCGTGCGCAGGCTGACGCCCAGCTGCGAGATCACCTTCATCGAG
TCGGAGGAGGGCAGTGGCCGGGGCGCGGCCCTGGTCTCGGCGGTGGCCTGTAAGAAGGCC
TGTATGCTGGGCCAGTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M88011

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_4_Locus:
7p15.3-p15.1

# Metabolic_Enzyme_4_SNPs:
rs2908275; rs2908276; rs13306390; rs13306391; rs2284776; rs2268572; rs2908290; rs741038; rs758989; rs2908289; rs2070971; rs2908296; rs758985; rs2268576; rs2268574; rs2300586; rs1990458; rs2908297; rs1303722; rs3808319; rs2300584; rs2971672; rs2284777; rs12540369; rs2268575; rs2908298; rs2010825; rs12535229; rs7793213; rs2908292; rs2971677; rs3808323; rs12534623; rs2971679; rs2268570; rs2908274; rs730497; rs11766576; rs3808322; rs12673242; rs2971678; rs17832252; rs2268573; rs2971674; rs2971671; rs4724290; rs2041547; rs758987; rs13239289; rs2268569; rs3808320; rs17172566; rs10246064; rs758988; rs16881016; rs2300587; rs3808321; rs887688; rs2284773; rs758986; rs887686; rs2244164; rs10259649; rs12702069; rs2284769; rs6952751; rs11768239; rs2080033; rs2971676; rs887687; rs2971675; rs2908293; rs6945550; rs13306387; rs2908291; rs12702068; rs12534104; rs2215644; rs1799884; rs1476891; rs2908277; rs12702070; rs34389297; rs13306389; rs35548117; rs34322372; rs13306388; rs13306393; rs41282709; rs35140467; rs13306392; rs35521280; rs34255297; rs28639899; rs741039; rs5883891; rs2284771; rs34710012; rs34691097; rs2971670; rs34288160; rs34574619; rs34807880; rs3216596; rs34265547; rs34672149; rs34973571; rs35368425; rs13227198; rs36094778; rs35276355; rs28491181; rs34859037; rs34947625; rs5883890; rs35079658; rs34780996; rs35606092; rs34124036; rs2971680; rs3065183; rs41282712; rs35786405; rs4724291; rs3840676; rs34675661; rs2284778; rs11447509; rs2284779; rs2268577; rs10680351; rs1303721; rs2908294; rs34114506; rs1799831; rs36084943; rs2908295; rs11974018; rs34380942; rs36118223; rs35568119; rs2284772; rs34185745; rs11772934; rs35262363; rs11412934; rs35723429; rs2284774; rs41282715; rs36193808; rs11287012; rs6971410; rs41314139; rs2284775; rs35688609; rs13239987; rs34178750; rs28684786; rs35620913; rs35907141; rs34976798; rs34359315; rs3779606; rs13306394; rs3840677; rs1076439; rs36205687; rs35670475; rs11372006; rs36205684; rs2971681; rs36205686; rs36205690; rs36205688; rs1008384; rs12669054; rs17135975; rs17136076; rs17172591; rs17769733; rs2080032; rs2908278; rs2908286; rs2971669; rs3757838; rs3757840; rs4397301; rs4607517; rs6953355; rs6975024; rs735670; rs737525; rs741033; rs741034; rs741035; rs741036; rs741037; rs758983; rs882019; rs882020; rs882021

# Metabolic_Enzyme_4_General_References:
1354840; 1871135; 1511800; 1612194; 1502186; 1464666; 8194664; 1303265; 8454109; 8495817; 8325892; 8446612; 8168652; 9049484; 9662401; 9435328; 10588527; 11106831; 11372010

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
6150

# Metabolic_Enzyme_5_Name:
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

# Metabolic_Enzyme_5_Synonyms:
Processing alpha-1,2-mannosidase IB; Alpha-1,2-mannosidase IB; Mannosidase alpha class 1A member 2

# Metabolic_Enzyme_5_Gene_Name:
MAN1A2

# Metabolic_Enzyme_5_Protein_Sequence:
>Mannosyloligosaccharide 1,2alphamannosidase 
IBMTTPALLPLSGRRIPPLNLGPPSFPHHRATLRLSEKFILLLILSAFITLCFGAFFFLP
DSSKHKRFDLGLEDVLIPHVDAGKGAKNPGVFLIHGPDEHRHREEEERLRNKIRADHEKA
LEEAKEKLRKSREEIRAEIQTEKNKVVQEMKIKENKPLPPVPIPNLVGIRGGDPEDNDIR
EKREKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMG
LHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEKL
LPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYKK
VMHIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDHE
ARKMYDDAIEAIEKHLIKKSRGGLTFIGEWKNGHLEKKMGHLACFAGGMFALGADGSRAD
KAGHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIETY
WYLWRFTHDPRYRQWGWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAETLK
YLYLLFSGDDLLPLDHWVFNTEAHPLPVLHLANTTLSGNPAVR

# Metabolic_Enzyme_5_Number_of_Residues:
641

# Metabolic_Enzyme_5_Molecular_Weight:
73004

# Metabolic_Enzyme_5_Theoretical_pI:
7.67

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  mannosidase activity
Function:  mannosyl-oligosaccharide mannosidase activity
Function:  mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
Process:  protein amino acid N-linked glycosylation
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)

# Metabolic_Enzyme_5_Pathway:
map00510  N-Glycan biosynthesis;
 map00513  High-mannose type N-glycan biosynthesis

# Metabolic_Enzyme_5_Reaction:
Hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01532:Glyco_hydro_47

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
37-57

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.2.1.113

# Metabolic_Enzyme_5_GenBank_ID_Protein:
3025750

# Metabolic_Enzyme_5_SwissProt_ID:
MA1A2_HUMAN (O60476)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
MAN1A2

# Metabolic_Enzyme_5_Geneatlas_id:
MAN1A2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:6822

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_5_Gene_Sequence:
>758 bp
ATCATACATCTGTCGGTGGCCTGGGAGACAGTTTTTATGAATACTTACTGAAAGCATGGT
TGATGTCAGATAAAACAGACCATGAGGCAAGAAAGATGTATGATGATGCTATTGAGGCTA
TAGAAAAACATCTTATTAAGAAGTCTCGTGGAGGTCTTACCTTTATTGGAGAATGGAAGA
ATGGGCACTTGGAAAAAAAGATGGGGCATTTGGCCTGCTTTGCTGGGGGAATGTTTGCAC
TAGGAGCAGATGGTTCCAGAGCAGATAAAGCTGGTCATTATTTAGAGCTAGGGGCAGAAA
TTGCACGTACTTGTCATGAGTCATATGACAGAACTGCATTAAAGCTAGGTCCTGAATCAT
TCAAGTTTGATGGTGCAGTGGAGGCTGTGGCTGTCCGGCAGGCTGAAAAGTATTATATCC
TCCGTCCAGAAGTAATTGAAACCTATTGGTACCTATGGCGATTCACTCACGATCCAAGAT
ACAGGCAGTGGGGCTGGGAAGCAGCACTGGCCATTGAAAAGTATTGCCGAGTTAATGGTG
GGTTTTCTGGAGTCAAAGATGTATATTCCTCTACTCCTACACATGATGATGTACAGCAGA
GCTTTTTTCTTGCTGAAACATTAAAATATTTGTATCTGCTGTTCTCCGGTGATGACCTTT
TACCTTTAGACCACTGGGTGTTTAATACAGAGGCTCACCCTCTGCCTGTGTTACATTTAG
CCAACACCACACTTTCAGGTAATCCTGCTGTTCGATGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AF053626

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_5_Locus:
1p13

# Metabolic_Enzyme_5_SNPs:
rs12064832; rs1146297; rs1290558; rs9951; rs10923273; rs1043476; rs12120771; rs964530; rs953119; rs1289952; rs2256057; rs1289957; rs1774853; rs1289951; rs1316011; rs1289938; rs7546624; rs10923293; rs7522264; rs7546882; rs3767797; rs1289947; rs1290541; rs10923322; rs7540437; rs7553018; rs6686707; rs4460623; rs7547211; rs884748; rs10923323; rs10923297; rs6686469; rs10923328; rs1290539; rs1289959; rs3767793; rs2359248; rs2359247; rs3767803; rs2790033; rs10923294; rs3820500; rs1146299; rs7531715; rs9727433; rs10754344; rs10923321; rs12401325; rs2211129; rs3767790; rs11577335; rs10923326; rs12121530; rs1289820; rs12073066; rs1289948; rs11580284; rs12144850; rs1934251; rs10399934; rs1934249; rs11586311; rs1289961; rs7539143; rs1146298; rs17185254; rs1290552; rs3767798; rs12562844; rs10801959; rs3767802; rs3767791; rs10923292; rs2153255; rs11576543; rs3767796; rs6662424; rs10923300; rs12562003; rs946519; rs12094837; rs1289940; rs7514323; rs10923309; rs1290544; rs1289939; rs11581669; rs1289944; rs11587759; rs10923278; rs6700910; rs7537915; rs12407224; rs10801962; rs6660349; rs10923289; rs1475393; rs12141947; rs10923281; rs12091306; rs3767799; rs1290551; rs6683931; rs17037333; rs10923284; rs10923296; rs10923310; rs10923304; rs2306444; rs6677348; rs12407227; rs1289941; rs1290543; rs12134265; rs11805638; rs12065396; rs1290545; rs1290554; rs1934250; rs10923303; rs10923295; rs10923312; rs12131109; rs10923311; rs1319914; rs12565510; rs1009549; rs10923325; rs1290546; rs7517876; rs10923301; rs17037335; rs11584944; rs10923279; rs1289956; rs12080559; rs12745755; rs12402402; rs17037349; rs17037313; rs17037223; rs1290556; rs10923313; rs7542401; rs1290548; rs17037239; rs1290553; rs3767795; rs10801961; rs10923286; rs10923318; rs7539447; rs11590318; rs12084686; rs10923285; rs975128; rs11801339; rs12086745; rs10923298; rs11801552; rs11577788; rs3920835; rs11589313; rs17037253; rs7543108; rs6686617; rs17545441; rs10923299; rs12128776; rs4659325; rs6690876; rs12402290; rs17037334; rs12410819; rs1890626; rs1289955; rs1290550; rs10923314; rs10801957; rs12074856; rs1290555; rs1290549; rs11582889; rs6673496; rs3767794; rs10923319; rs7546280; rs12403022; rs12061184; rs7546429; rs12127779; rs1289949; rs12124365; rs12081574; rs12083641; rs12080545; rs12127141; rs17037323; rs1289960; rs7517482; rs12079374; rs17037231; rs6675822; rs12141030; rs12071415; rs12081376; rs11807022; rs7539337; rs10923305; rs17037321; rs17037347; rs10923315; rs11584900; rs12074058; rs12083905; rs1299463; rs12129406; rs12117874; rs17037307; rs1289962; rs7552473; rs11583061; rs12732348; rs17037340; rs10923308; rs12406940; rs2211130; rs1289953; rs7539433; rs1768790; rs7547042; rs969270; rs11590033; rs7536598; rs6665954; rs10923320; rs12078488; rs1289945; rs11802416; rs17037233; rs17037296; rs10923283; rs7513311; rs10923280; rs1768791; rs1290540; rs7542215; rs1290542; rs1934247; rs7552103; rs1679821; rs7531617; rs12078981; rs6692078; rs17037245; rs10801960; rs10923316; rs1290557; rs1146300; rs1289954; rs7525312; rs17037310; rs10923274; rs17037248; rs12401357; rs12729810; rs12093932; rs12093431; rs6657308; rs10923287; rs2211131; rs12087550; rs1289958; rs4659050; rs17185268; rs3820501; rs4360510; rs12402089; rs10923290; rs12078528; rs12131343; rs10923291; rs2622364; rs3754118; rs1053902; rs1342389; rs12126437; rs3754117; rs41296190; rs34355735; rs41299569; rs41312694; rs36066599; rs41310116; rs35321634; rs41306205; rs41312696; rs9783031; rs28481800; rs5777312; rs12083328; rs1679820; rs34989844; rs6688608; rs4468152; rs34499854; rs41506254; rs12065381; rs12060776; rs34753069; rs12078149; rs12116979; rs34938045; rs35262182; rs35492496; rs7517752; rs2185783; rs13353025; rs36074979; rs12758574; rs34130906; rs35601822; rs34597741; rs34828761; rs10923307; rs3820502; rs1289943; rs12738290; rs12063923; rs35889322; rs10569118; rs10157879; rs12141846; rs12120302; rs35783854; rs6664797; rs11807303; rs7529424; rs41276586; rs12568394; rs35505705; rs10923275; rs11339369; rs34656419; rs35650235; rs35218627; rs12733957; rs3835642; rs35179631; rs36020568; rs34594031; rs35460184; rs35445569; rs6678392; rs12121217; rs6688463; rs35030664; rs35894696; rs34827627; rs35113677; rs12070930; rs5777309; rs12069696; rs34674212; rs5777313; rs35035676; rs28631236; rs12067221; rs5777311; rs34388806; rs35818638; rs35933447; rs1290547; rs12072554; rs10560421; rs34490699; rs35643169; rs35720263; rs10923282; rs7553086; rs12064131; rs12027777; rs1146301; rs6702187; rs35743965; rs35041320; rs4406616; rs12093620; rs34271998; rs33969366; rs28480548; rs12085580; rs34266581; rs3767801; rs12063921; rs34938227; rs12734150; rs12117443; rs35480509; rs6697740; rs6677475; rs12063924; rs12128361; rs13375328; rs34482916; rs35949328; rs10923306; rs35972954; rs11346145; rs34735635; rs7418041; rs34671457; rs3835640; rs12067071; rs1934248; rs6678840; rs35058662; rs12037503; rs12732711; rs35878802; rs35063386; rs34157544; rs34368690; rs12734157; rs6685051; rs34705950; rs10923330; rs35979517; rs12123364; rs12030644; rs3835643; rs7529521; rs5777310; rs12093047; rs12145435; rs12728879; rs35953056; rs10673011; rs6703969; rs12070661; rs10923332; rs11587386; rs6688396; rs12406451; rs1315646; rs1316326; rs12142241; rs3050979; rs12139939; rs12410687; rs28833032; rs9699748; rs12045086; rs13374745; rs35286652; rs12184255; rs12075646; rs10717316; rs35596695; rs34628629; rs3767804; rs12743363; rs28632100; rs35257126; rs35226571; rs34782879; rs10923277; rs12025586; rs34368125; rs3820499; rs34524856; rs10923288; rs28864972; rs35900538; rs34356036; rs35992205; rs7545192; rs12065410; rs10157880; rs12077929; rs34743811; rs9701808; rs2796206; rs12728046; rs10923329; rs35692790; rs35011603; rs35379428; rs11799894; rs17037337; rs35366633; rs35061924; rs35165743; rs34575612; rs34089214; rs12075562; rs12724274; rs11335667; rs12082911; rs34032405; rs12723362; rs35914040; rs12058252; rs3835639; rs12076228; rs12754801; rs10923331; rs10923324; rs35527987; rs36043260; rs35113676; rs34282298; rs11355871; rs11415248; rs12088844; rs34420548; rs10687035; rs11806239; rs34249748; rs10923333; rs11355628; rs12126528; rs28546869; rs35568370; rs7512060; rs34375872; rs9700547; rs35348385; rs35418262; rs3835644; rs12140576; rs4466644; rs12137488; rs34594518; rs12238974; rs11580502; rs36005000; rs4659328; rs3831976; rs7537608; rs34129780; rs12135190; rs3835641; rs34612489; rs36027204; rs35736606; rs12402086; rs12734477; rs10157878; rs35877767; rs36010467; rs6673773; rs12077758; rs3767792; rs3216042; rs34016472; rs12117151; rs12566919; rs12049595; rs34352027; rs6677451; rs3083707; rs11585405; rs12240124; rs12733958; rs35699544; rs35352290; rs11362198; rs6662808; rs1578884; rs34350477; rs35570673; rs35719630; rs35414541; rs7539728; rs35080278; rs28608016; rs10586922; rs1289942; rs4659047; rs35538502; rs10923276; rs35241651; rs12081654; rs12729962; rs1289946; rs6678043; rs34967006; rs12022785; rs2767318; rs35764811; rs1045666; rs1045691; rs10884; rs10923334; rs1146295; rs1146296; rs11576919; rs11587306; rs11805345; rs12124341; rs12137146; rs12408612; rs17037373; rs2182599; rs2622365; rs2767319; rs35289635; rs6667122; rs6676578; rs946520; rs9681

# Metabolic_Enzyme_5_General_References:
9592125

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5447

# Metabolic_Enzyme_6_Name:
Hexokinase-1

# Metabolic_Enzyme_6_Synonyms:
Hexokinase type I; HK I; Brain form hexokinase

# Metabolic_Enzyme_6_Gene_Name:
HK1

# Metabolic_Enzyme_6_Protein_Sequence:
>Hexokinase1
MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT
VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH
GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV
EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME
ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM
YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG
VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH
PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT
KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV
LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF
TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG
TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD
IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG
IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA
VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG
AALITAVGVRLRTEASS

# Metabolic_Enzyme_6_Number_of_Residues:
917

# Metabolic_Enzyme_6_Molecular_Weight:
102487

# Metabolic_Enzyme_6_Theoretical_pI:
6.78

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_6_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism;
 map00521  Streptomycin biosynthesis;
 map00530  Aminosugars metabolism

# Metabolic_Enzyme_6_Reaction:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00349:Hexokinase_1;
PF03727:Hexokinase_2

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.7.1.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
184021

# Metabolic_Enzyme_6_SwissProt_ID:
HXK1_HUMAN (P19367)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
HK1

# Metabolic_Enzyme_6_Geneatlas_id:
HK1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:4922

# Metabolic_Enzyme_6_PDB_ID:
1HKB

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding

# Metabolic_Enzyme_6_Gene_Sequence:
>2754 bp
ATGATCGCCGCGCAGCTCCTGGCCTATTACTTCACGGAGCTGAAGGATGACCAGGTCAAA
AAGATTGACAAGTATCTGTATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATG
ACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTAATCCAACAGCCACA
GTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGAAAAGGGAGATTTC
ATTGCCCTGGATCTTGGTGGGTCTTCCTTTCGAATTCTGCGGGTGCAAGTGAATCATGAG
AAAAACCAGAATGTTCACATGGAGTCCGAGGTTTATGACACCCCAGAGAACATCGTGCAC
GGCAGTGGAAGCCAGCTTTTTGATCATGTTGCTGAGTGCCTGGGAGATTTCATGGAGAAA
AGGAAGATCAAGGACAAGAAGTTACCTGTGGGATTCACGTTTTCTTTTCCTTGCCAACAA
TCCAAAATAGATGAGGCCATCCTGATCACCTGGACAAAGCGATTTAAAGCGAGCGGAGTG
GAAGGAGCAGATGTGGTCAAACTGCTTAACAAAGCCATCAAAAAGCGAGGGGACTATGAT
GCCAACATCGTAGCTGTGGTGAATGACACAGTGGGCACCATGATGACCTGTGGCTATGAC
GACCAGCACTGTGAAGTCGGCCTGATCATCGGCACTGGCACCAATGCTTGCTACATGGAG
GAACTGAGGCACATTGATCTGGTGGAAGGAGACGAGGGGAGGATGTGTATCAATACAGAA
TGGGGAGCCTTTGGAGACGATGGATCATTAGAAGACATCCGGACAGAGTTTGACAGGGAG
ATAGACCGGGGATCCCTCAACCCTGGAAAACAGCTGTTTGAGAAGATGGTCAGTGGCATG
TACTTGGGAGAGCTGGTTCGACTGATCCTAGTCAAGATGGCCAAGGAGGGCCTCTTATTT
GAAGGGCGGATCACCCCGGAGCTGCTCACCCGAGGGAAGTTTAACACCAGTGATGTGTCA
GCCATCGAAAAGAATAAGGAAGGCCTCCACAATGCCAAAGAAATCCTGACCCGCCTGGGA
GTGGAGCCGTCCGATGATGACTGTGTCTCAGTCCAGCACGTTTGCACCATTGTCTCATTT
CGCTCAGCCAACTTGGTGGCTGCCACACTGGGCGCCATCTTGAACCGCCTGCGTGATAAC
AAGGGCACACCCAGGCTGCGGACCACGGTTGGTGTCGACGGATCTCTTTACAAGACGCAC
CCACAGTATTCCCGGCGTTTCCACAAGACTCTAAGGCGCTTGGTGCCAGACTCCGATGTG
CGCTTCCTCCTCTCGGAGAGTGGCAGCGGCAAGGGGGCTGCCATGGTGACGGCGGTGGCC
TACCGCTTGGCCGAGCAGCACCGGCAGATAGAGGAGACCCTGGCTCATTTCCACCTCACC
AAAGACATGCTGCTGGAGGTGAAGAAGAGGATGCGGGCCGAGATGGAGCTGGGGCTGAGG
AAGCAGACGCACAACAATGCCGTGGTTAAGATGCTGCCCTCCTTCGTCCGGAGAACTCCC
GACGGGACCGAGAATGGTGACTTCTTGGCCCTGGATCTTGGAGGAACCAATTTCCGTGTG
CTGCTGGTGAAAATCCGTAGTGGGAAAAAGAGAACGGTGGAAATGCACAACAAGATCTAC
GCCATTCCTATTGAAATCATGCAGGGCACTGGGGAAGAGCTGTTTGATCACATTGTCTCC
TGCATCTCTGACTTCTTGGACTACATGGGGATCAAAGGCCCCAGGATGCCTCTGGGCTTC
ACGTTCTCATTTCCCTGCCAGCAGACGAGTCTGGACGCGGGAATCTTGATCACGTGGACA
AAGGGTTTTAAGGCAACAGACTGCGTGGGCCACGATGTAGTCACCTTACTAAGGGATGCG
ATAAAAAGGAGAGAGGAATTTGACCTGGACGTGGTGGCTGTGGTCAACGACACAGTGGGC
ACCATGATGACCTGTGCTTATGAGGAGCCCACCTGTGAGGTTGGACTCATTGTTGGGACC
GGCAGCAATGCCTGCTACATGGAGGAGATGAAGAACGTGGAGATGGTGGAGGGGGACCAG
GGGCAGATGTGCATCAACATGGAGTGGGGGGCCTTTGGGGACAACGGGTGTCTGGATGAT
ATCAGGACACACTACGACAGACTGGTGAACGAATATTCCCTAAATGCTGGGAAACAAAGG
TATGAGAAGATGATCAGTGGTATGTACCTGGGTGAAATCGTCCGCAACATCTTAATCGAC
TTCACCAAGAAGGGATTCCTCTTCCGAGGGCAGATCTCTGAGACGATGAAGACCCGGGGC
ATCTTTGAGACCAAGTTTCTCTCTCAGATCGAGAGTGACCGATTAGCACTGCTCCAGGTC
CGGGCTATCCTCCAGCAGCTAGGTCTGAATAGCACCTGCGATGACAGTATCCTCGTCAAG
ACAGTGTGCGGGGTGGTGTCCAGGAGGGCCGCACAGCTGTGTGGCGCAGGCATGGCTGCG
GTTGTGGATAAGATCCGCGAGAACAGAGGACTGGACCGTCTGAATGTGACTGTGGGAGTG
GACGGGACACTCTACAAGCTTCATCCACACTTCTCCAGAATCATGCACCAGACGGTGAAG
GAACTGTCACCAAAATGTAACGTGTCCTTCCTCCTGTCTGAGGATGGCAGCGGCAAGGGG
GCCGCCCTCATCACGGCCGTGGGCGTGCGGTTACGCACAGAGGCAAGCAGCTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M75126

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_6_Locus:
10q22

# Metabolic_Enzyme_6_SNPs:
rs906220; rs1054203; rs748235; rs12254258; rs1133189; rs10998760; rs34616021; rs14006; rs2394539; rs10998704; rs6480394; rs10762281; rs3812689; rs10998703; rs4746834; rs7893994; rs4469773; rs7914134; rs1472817; rs2894081; rs11815833; rs2394540; rs10823332; rs10762280; rs10762277; rs2394543; rs7897621; rs4746837; rs7068435; rs13139; rs1876257; rs5030916; rs10998700; rs11819086; rs12257270; rs2394545; rs11818777; rs10998699; rs10762275; rs7907176; rs7903625; rs12216; rs10998702; rs1472819; rs2394541; rs7095428; rs1472816; rs2394538; rs10823333; rs10998692; rs11813648; rs11818779; rs10762276; rs10823329; rs12242964; rs12242332; rs10762273; rs1472818; rs11818927; rs10998684; rs2394535; rs11815263; rs7095547; rs10823328; rs10823335; rs12751; rs10823331; rs10998694; rs11815943; rs11815513; rs4746833; rs12244771; rs10762278; rs10823334; rs2894080; rs11818799; rs5030886; rs2394537; rs2089356; rs10998696; rs10998689; rs11819674; rs10762279; rs7092374; rs10823330; rs2002905; rs12263326; rs4372334; rs10998691; rs11816714; rs12265826; rs4746836; rs10740318; rs7095424; rs12218331; rs7907242; rs5030949; rs11816128; rs7095579; rs12241382; rs1867972; rs2084274; rs1867971; rs906215; rs1867975; rs749108; rs2305198; rs4537657; rs7084213; rs11596193; rs7909192; rs2305196; rs1227938; rs7072268; rs10823348; rs10159541; rs7094651; rs7084363; rs1900466; rs12414591; rs10762288; rs10733851; rs7921170; rs7921060; rs7095140; rs749107; rs10762282; rs2015803; rs6480396; rs6480404; rs1867973; rs3812691; rs10998738; rs11595647; rs11812791; rs10823360; rs9664217; rs4745988; rs10823350; rs10159477; rs10823357; rs12243794; rs4746848; rs10998730; rs7097078; rs749105; rs7071731; rs4745987; rs16926253; rs7076563; rs3793846; rs10998725; rs2305197; rs4072508; rs7898060; rs11597346; rs6480400; rs11596110; rs7092155; rs2394560; rs4745981; rs4589168; rs11595655; rs10823343; rs3829185; rs11599680; rs10823354; rs6480403; rs12262904; rs10998751; rs4746838; rs10823349; rs11819564; rs10762292; rs1867974; rs906216; rs2278745; rs10998754; rs10823356; rs10159540; rs11818709; rs4746839; rs7079157; rs7088667; rs7094214; rs11599150; rs4746846; rs11598389; rs1900467; rs10823345; rs12265560; rs10762290; rs2394561; rs10823355; rs10823340; rs12244847; rs2305199; rs4746841; rs749106; rs7913579; rs7076745; rs3793845; rs10823341; rs11596587; rs11596868; rs10998720; rs7905437; rs7917338; rs6480402; rs7914033; rs16926244; rs3829183; rs7067927; rs7912524; rs12416320; rs16926252; rs12571072; rs4746849; rs11596199; rs10823339; rs10998728; rs6480398; rs10823342; rs11813750; rs12415409; rs10998739; rs10762284; rs10998742; rs10823353; rs10998741; rs10128334; rs7895704; rs7902303; rs4745982; rs11818471; rs10159490; rs4746847; rs10128330; rs10762285; rs5030915; rs10998719; rs12252483; rs7072349; rs6480399; rs4745986; rs10998752; rs10998710; rs7905515; rs3793847; rs7904932; rs17489768; rs12255367; rs10998747; rs34895304; rs12240847; rs10823358; rs17567544; rs906221; rs12251732; rs10823338; rs10823351; rs9299503; rs10998726; rs10998735; rs12253797; rs10998706; rs7067730; rs12248026; rs12243312; rs12262357; rs4471325; rs11599654; rs12252916; rs3793844; rs7081302; rs10998715; rs12262687; rs16926246; rs7905243; rs10823352; rs10823337; rs10762286; rs10823359; rs10128513; rs10998748; rs17476364; rs10159599; rs11597225; rs10823344; rs10998736; rs7902486; rs12220752; rs7094943; rs7920991; rs10998731; rs16926242; rs10998723; rs12254195; rs10762293; rs4746851; rs7899625; rs16926292; rs10159598; rs2135589; rs10823347; rs4364944; rs7077298; rs10998716; rs16926249; rs11599655; rs12243716; rs7097551; rs10998744; rs10762283; rs12771121; rs7083032; rs12411628; rs10762287; rs10762291; rs7913272; rs12355201; rs5030917; rs10998733; rs10998740; rs1108272; rs4746850; rs11819352; rs10823346; rs12778692; rs6480397; rs11593167; rs11816511; rs11812380; rs10998724; rs2394534; rs1054202; rs34410083; rs35378602; rs41279658; rs12356717; rs35387972; rs12243655; rs35468118; rs1803712; rs10998693; rs35379025; rs5785909; rs35517819; rs35080013; rs34434447; rs10998687; rs28558590; rs12357729; rs12219469; rs12780875; rs34997376; rs35104096; rs12780655; rs10762274; rs34150929; rs12263929; rs10998698; rs10998690; rs10716029; rs2394542; rs12221426; rs4282890; rs12569892; rs7916281; rs35143457; rs2394536; rs36020756; rs3086615; rs7083056; rs10998695; rs1810023; rs2063048; rs36007468; rs10998688; rs11286202; rs35585147; rs28422950; rs35431404; rs12242466; rs35264480; rs35699014; rs14382; rs34382339; rs34539856; rs5785910; rs4745980; rs4638197; rs5785908; rs34031234; rs12262447; rs11815616; rs34736420; rs10672043; rs35376303; rs34164890; rs12253706; rs7914285; rs4622145; rs34547808; rs11556966; rs34453032; rs10998685; rs12241639; rs10998686; rs10998701; rs10998697; rs10400052; rs12268098; rs11819094; rs35607669; rs7905200; rs2394544; rs3750793; rs35895463; rs7083200; rs12220458; rs7914344; rs12259682; rs12571243; rs7894213; rs34610927; rs12253579; rs35804876; rs41279664; rs5030950; rs34938278; rs12242474; rs34931035; rs12780492; rs35306200; rs34327925; rs1057566; rs11819447; rs10668853; rs4453112; rs41279662; rs12252651; rs10998745; rs36104030; rs12247331; rs33984080; rs4366384; rs35347843; rs35619781; rs11592707; rs34834335; rs891564; rs34694521; rs35135619; rs5785912; rs34040090; rs35627580; rs10578071; rs6143971; rs1867970; rs12780794; rs10998734; rs11816980; rs35368978; rs10998714; rs11597178; rs34605664; rs10998756; rs7478446; rs34064357; rs11497990; rs10688656; rs7911813; rs7476246; rs12254694; rs34142395; rs35932296; rs1867976; rs12252489; rs35684348; rs35802626; rs36006142; rs35233497; rs10998757; rs16926233; rs10998709; rs10998722; rs12240898; rs34164799; rs34068824; rs41435648; rs35975244; rs34124986; rs35131910; rs11819725; rs11424399; rs906223; rs7476298; rs35300718; rs10998729; rs36006221; rs5785913; rs11597418; rs34156889; rs11592659; rs10679551; rs10159538; rs10998755; rs35790367; rs36124339; rs5030919; rs16926269; rs41279656; rs12264809; rs35680310; rs11596222; rs34391428; rs36012744; rs34821837; rs10580275; rs10998718; rs12769898; rs7090983; rs34729523; rs35983460; rs11598601; rs34428846; rs11597672; rs35532806; rs10998708; rs35337416; rs2089357; rs3086649; rs10998746; rs10684489; rs5019350; rs12248865; rs35385375; rs35827992; rs11400433; rs10128509; rs35246952; rs35351562; rs33920450; rs10998707; rs35258842; rs10998737; rs16926245; rs34348007; rs12765788; rs12248628; rs7911786; rs10998743; rs17489948; rs34969484; rs6480401; rs12258259; rs34967951; rs11591962; rs41279660; rs35833065; rs10998759; rs3086686; rs12782422; rs10998711; rs35024696; rs34137364; rs33920304; rs35326884; rs34301815; rs35860582; rs906222; rs35929312; rs7093863; rs11389885; rs10998705; rs3812690; rs7081298; rs2894082; rs12360012; rs34309168; rs12769387; rs41279654; rs36096331; rs34767311; rs36022169; rs12247649; rs10542467; rs12770156; rs12259309; rs12245854; rs35510140; rs10998750; rs12357558; rs34815317; rs35215102; rs3956966; rs35733293; rs12765993; rs4745983; rs11295023; rs5019351; rs10998753; rs10998727; rs12769386; rs11421011; rs12243746; rs34133918; rs12356440; rs34966318; rs35451830; rs7094375; rs12359036; rs12763363; rs34977762; rs10047284; rs10998758; rs12098572; rs35694546; rs10603617; rs10531274; rs35035641; rs10998717; rs11593738; rs12257925; rs5030918; rs34367822; rs35534322; rs4745984; rs7072757; rs12243670; rs7088597; rs11267589; rs12411524; rs35376932; rs34620768; rs10823336; rs11597926; rs10998712; rs28510843; rs10536437; rs35922004; rs12263320; rs35828572; rs12246003; rs7094252; rs6480405; rs10998749; rs10159790; rs35341389; rs10998713; rs12264596; rs2278744; rs34085490; rs4746840; rs34767665; rs10998732; rs35490740; rs35026222; rs34941976; rs34818501; rs12264010; rs34125846; rs10998682; rs34564828; rs34015903; rs34747241; rs1000251; rs10740320; rs10998677; rs10998679; rs10998762; rs11813340; rs11815413; rs11817458; rs12244723; rs1227958; rs12776509; rs12781552; rs1549797; rs1549798; rs1549799; rs16926201; rs2278746; rs2611; rs34690134; rs35008643; rs3740601; rs3793849; rs3793850; rs3793851; rs4603200; rs4644560; rs4746832; rs6480393; rs7097827; rs7097971; rs7098065; rs906219; rs986525

# Metabolic_Enzyme_6_General_References:
3207429; 9531504; 1637300; 1985912; 9028305; 10978502; 8706938; 9493266; 9735292; 10574795; 10686099; 7655856

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
6151

# Metabolic_Enzyme_7_Name:
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

# Metabolic_Enzyme_7_Synonyms:
ER alpha-1,2-mannosidase; Mannosidase alpha class 1B member 1; Man9GlcNAc2-specific-processing alpha-mannosidase

# Metabolic_Enzyme_7_Gene_Name:
MAN1B1

# Metabolic_Enzyme_7_Protein_Sequence:
>Endoplasmic reticulum mannosyloligosaccharide 1,2alphamannosidase
MAACEGRRSGALGSSQSDFLTPPVGGAPWAVATTVVMYPPPPPPPHRDFISVTLSFGENY
DNSKSWRRRSCWRKWKQLSRLQRNMILFLLAFLLFCGLLFYINLADHWKALAFRLEEEQK
MRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDG
TQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQ
GTPVHLNYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWI
LGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGN
RLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEA
VEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQE
TQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVYHG
LPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPET
VESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFF
LGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPIWTPA

# Metabolic_Enzyme_7_Number_of_Residues:
699

# Metabolic_Enzyme_7_Molecular_Weight:
79581

# Metabolic_Enzyme_7_Theoretical_pI:
7.80

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  mannosidase activity
Function:  mannosyl-oligosaccharide mannosidase activity
Function:  mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
Process:  protein amino acid N-linked glycosylation
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Involved in the maturation of Asn-linked oligosaccharides. Trim a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2). The only product is the Man(8)GlcNAc(2) isomer B, the form lacking the middle-arm terminal alpha 1,2-mannose. It may be involved in glycoprotein quality control since it is important to target misfolded glycoproteins for degradation

# Metabolic_Enzyme_7_Pathway:
map00510  N-Glycan biosynthesis;
 map00513  High-mannose type N-glycan biosynthesis

# Metabolic_Enzyme_7_Reaction:
Hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF01532:Glyco_hydro_47

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
85-105

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.2.1.113

# Metabolic_Enzyme_7_GenBank_ID_Protein:
6066222

# Metabolic_Enzyme_7_SwissProt_ID:
MA1B1_HUMAN (Q9UKM7)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
MAN1B1

# Metabolic_Enzyme_7_Geneatlas_id:
MAN1B1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:6823

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass type II membrane protein

# Metabolic_Enzyme_7_Gene_Sequence:
>2100 bp
ATGGCTGCCTGCGAGGGCAGGAGAAGCGGAGCTCTCGGTTCCTCTCAGTCGGACTTCCTG
ACGCCGCCAGTGGGCGGGGCCCCTTGGGCCGTCGCCACCACTGTAGTCATGTACCCACCG
CCGCCGCCGCCGCCTCATCGGGACTTCATCTCGGTGACGCTGAGCTTTGGCGAGAGCTAT
GACAACAGCAAGAGTTGGCGGCGGCGCTCGTGCTGGAGGAAATGGAAGCAACTGTCGAGA
TTGCAGCGGAATATGATTCTCTTCCTCCTTGCCTTTCTGCTTTTCTGTGGACTCCTCTTC
TACATCAACTTGGCTGACCATTGGAAAGCTCTGGCTTTCAGGCTAGAGGAAGAGCAGAAG
ATGAGGCCAGAAATTGCTGGGTTAAAACCAGCAAATCCACCCGTCTTACCAGCTCCTCAG
AAGGCGGACACCGACCCTGAGAACTTACCTGAGATTTCGTCACAGAAGACACAAAGACAC
ATCCAGCGGGGACCACCTCACCTGCAGATTAGACCCCCAAGCCAAGACCTGAAGGATGGG
ACCCAGGAGGAGGCCACAAAAAGGCAAGAAGCCCCTGTGGATCCCCGCCCGGAAGGAGAT
CCGCAGAGGACAGTCATCAGCTGGAGGGGAGCGGTGATCGAGCCTGAGCAGGGCACCGAG
CTCCCTTCAAGAAGAGCAGAAGTGCCCACCAAGCCTCCCCTGCCACCGGCCAGGACACAG
GGCACACCAGTGCATCTGAACTATCGCCAGAAGGGCGTGATTGACGTCTTCCTGCATGCA
TGGAAAGGATACCGCAAGTTTGCATGGGGCCATGACGAGCTGAAGCCTGTGTCCAGGTCC
TTCAGTGAGTGGTTTGGCCTCGGTCTCACACTGATCGACGCGCTGGACACCATGTGGATC
TTGGGTCTGAGGAAAGAATTTGAGGAAGCCAGGAAGTGGGTGTCGAAGAAGTTACACTTT
GAAAAGGACGTGGACGTCAACCTGTTTGAGAGCACGATCCGCATCCTGGGGGGGCTCCTG
AGTGCCTACCACCTGTCTGGGGACAGCCTCTTCCTGAGGAAAGCTGAGGATTTTGGAAAT
CGGCTAATGCCTGCCTTCAGAACACCATCCAAGATTCCTTACTCGGATGTGAACATCGGT
ACTGGAGTTGCCCACCCGCCACGGTGGACCTCCGACAGCACTGTGGCCGAGGTGACCAGC
ATTCAGCTGGAGTTCCGGGAGCTCTCCCGTCTCACAGGGGATAAGAAGTTTCAGGAGGCA
GTGGAGAAGGTGACACAGCACATCCACGGCCTGTCTGGGAAGAAGGATGGGCTGGTGCCC
ATGTTCATCAATACCCACAGTGGCCTCTTCACCCACCTGGGCGTATTCACGCTGGGCGCC
AGGGCCGACAGCTACTATGAGTACCTGCTGAAGCAGTGGATCCAGGGCGGGAAGCAGGAG
ACACAGCTGCTGGAAGACTACGTGGAAGCCATCGAGGGTGTCAGAACGCACCTGCTGCGG
CACTCCGAGCCCAGTAAGCTCACCTTTGTGGGGGAGCTTGCCCACGGCCGCTTCAGTGCC
AAGATGGACCACCTGGTGTGCTTCCTGCCAGGGACGCTGGCTCTGGGCGTCTACCACGGC
CTGCCCGCCAGCCACATGGAGCTGGCCCAGGAGCTCATGGAGACTTGTTACCAGATGAAC
CGGCAGATGGAGACGGGGCTGAGTCCCGAGATCGTGCACTTCAACCTTTACCCCCAGCCG
GGCCGTCGGGACGTGGAGGTCAAGCCAGCAGACAGGCACAACCTGCTGCGGCCAGAGACC
GTGGAGAGCCTGTTCTACCTGTACCGCGTCACAGGGGACCGCAAATACCAGGACTGGGGC
TGGGAGATTCTGCAGAGCTTCAGCCGATTCACACGGGTCCCCTCGGGTGGCTATTCTTCC
ATCAACAATGTCCAGGATCCTCAGAAGCCCGAGCCTAGGGACAAGATGGAGAGCTTCTTC
CTGGGGGAGACGCTCAAGTATCTGTTCTTGCTCTTCTCCGATGACCCAAACCTGCTCAGC
CTGGACGCCTACGTGTTCAACACCGAAGCCCACCCTCTGCCTATCTGGACCCCTGCCTAG


# Metabolic_Enzyme_7_GenBank_ID_Gene:
AF148509

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_7_Locus:
9q34

# Metabolic_Enzyme_7_SNPs:
rs968733; rs4880091; rs12000048; rs4567; rs4880089; rs4880199; rs4880201; rs3750518; rs7871579; rs10870177; rs4880200; rs4880090; rs10870178; rs4880202; rs4880206; rs9721691; rs6420280; rs9411307; rs12003126; rs12554429; rs7858257; rs7026787; rs4880203; rs4880204; rs12000517; rs10118812; rs11790092; rs11998970; rs7047669; rs11793243; rs7848423; rs1018330; rs7466635; rs7856589; rs7853589; rs10118245; rs7853336; rs34355967; rs35501192; rs34547052; rs10117795; rs36046941; rs35889987; rs7023666; rs34916024; rs7467333; rs34848814; rs10551956; rs9411305; rs35087531; rs35213886; rs4880205; rs28373932; rs35264358; rs7854509; rs35864058; rs35117502; rs33922627; rs36135008; rs9411308; rs35778934; rs4880207; rs4075382; rs12375806; rs35504773; rs34119148; rs5901117; rs13286324; rs9411306; rs35474986; rs35369881; rs10569516; rs11145992; rs34212731; rs12352987; rs4075381; rs34407611; rs35632605; rs12115325; rs34103067; rs11145990; rs34369409; rs12000204; rs35499495; rs11145993; rs11425109; rs35857851; rs36191094; rs11145994; rs34635386; rs7849827; rs10589398; rs34703858; rs13286038; rs9411249; rs35175604; rs34637771; rs36101237; rs11145991; rs13302226; rs35594085; rs34867505; rs35757228; rs34371589; rs13302343; rs13298199; rs11145995; rs13295091; rs13298125; rs968732; rs1401557; rs3750519; rs12115391; rs10701738; rs10119378; rs10870176; rs10870180; rs10870181; rs1105834; rs11145989; rs11146001; rs1122444; rs1128115; rs1128125; rs1128129; rs11788775; rs12002284; rs13631; rs17065341; rs2049039; rs34269599; rs4073309; rs4073310; rs4074598; rs4390039; rs4880092; rs4880198; rs6560658; rs6560660; rs7037849; rs7389436; rs7851653; rs7851870; rs7855894; rs7873997

# Metabolic_Enzyme_7_General_References:
10521544; 10409699; 12975309

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
6152

# Metabolic_Enzyme_8_Name:
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

# Metabolic_Enzyme_8_Synonyms:
Processing alpha-1,2-mannosidase IA; Alpha-1,2-mannosidase IA; Mannosidase alpha class 1A member 1; Man(9-alpha-mannosidase; Man9-mannosidase

# Metabolic_Enzyme_8_Gene_Name:
MAN1A1

# Metabolic_Enzyme_8_Protein_Sequence:
>Mannosyloligosaccharide 1,2alphamannosidase 
IAMPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGA
IFFLPDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALE
DNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVP
PIGVESREPADAAIREKRAKIKEMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNIKG
ATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGE
EIFRKKAVELGVKLLPAFHTPSGIPWALLNMKSGIGRNWPWASGGSSILAEFGTLHLEFM
HLSHLSGNPIFAEKVMNIRTVLNKLEKPQGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEY
LLKAWLMSDKTDLEAKKMYFDAVQAIETHLIRKSSSGLTYIAEWKGGLLEHKMGHLTCFA
GGMFALGADAAPEGMAQHYLELGAEIARTCHESYNRTFMKLGPEAFRFDGGVEAIATRQN
EKYYILRPEVMETYMYMWRLTHDPKYRKWAWEAVEALENHCRVNGGYSGLRDVYLLHESY
DDVQQSFFLAETLKYLYLIFSDDDLLPLEHWIFNSEAHLLPILPKDKKEVEIREE

# Metabolic_Enzyme_8_Number_of_Residues:
653

# Metabolic_Enzyme_8_Molecular_Weight:
72969

# Metabolic_Enzyme_8_Theoretical_pI:
6.44

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  mannosidase activity
Function:  mannosyl-oligosaccharide mannosidase activity
Function:  mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
Process:  protein amino acid N-linked glycosylation
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)

# Metabolic_Enzyme_8_Pathway:
map00510  N-Glycan biosynthesis;
 map00513  High-mannose type N-glycan biosynthesis

# Metabolic_Enzyme_8_Reaction:
Hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF01532:Glyco_hydro_47

# Metabolic_Enzyme_8_Signals:
1-19

# Metabolic_Enzyme_8_Transmembrane_Regions:
42-62

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.2.1.113

# Metabolic_Enzyme_8_GenBank_ID_Protein:
56202626

# Metabolic_Enzyme_8_SwissProt_ID:
MA1A1_HUMAN (P33908)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
MAN1A1

# Metabolic_Enzyme_8_Geneatlas_id:
MAN1A1

# Metabolic_Enzyme_8_hgnc_id:
HGNC:6821

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_8_Gene_Sequence:
>1146 bp
AATGCTGAAATTTCTGTCTTTGAAGTAAATATACGCTTTGTTGGTGGACTACTCTCAGCC
TACTATCTGTCTGGAGAAGAGATTTTTCGAAAGAAAGCAGTGGAACTTGGGGTAAAATTG
CTACCTGCATTTCATACTCCCTCTGGAATACCTTGGGCATTGCTGAATATGAAAAGTGGT
ATTGGAAGGAACTGGCCCTGGGCCTCTGGAGGCAGCAGTATTCTGGCAGAATTTGGAACC
CTGCATTTGGAGTTTATGCACTTGAGCCACTTATCAGGAAACCCCATCTTTGCTGAAAAG
GTAATGAATATTCGAACAGTACTGAACAAACTGGAAAAACCACAAGGCCTTTATCCTAAC
TATCTGAATCCCAGTAGTGGACAGTGGGGTCAACATCATGTATCAGTTGGAGGACTTGGA
GACAGCTTCTATGAGTATTTGCTGAAGGCCTGGTTAATGTCTGACAAGACAGATCTGGAA
GCTAAGAAGATGTATTTTGATGCTGTTCAGGCTATCGAGACTCATTTGATCCGCAAGTCT
AGCAGCGGACTAACTTATATCGCAGAGTGGAAAGGGGGCCTCCTGGAGCACAAGATGGGC
CACCTGACCTGCTTCGCGGGGGGCATGTTCGCACTCGGGGCTGATGCAGCTCCCGAAGGC
ATGGCCCAACACTACCTTGAACTCGGGGCTGAAATTGCCCGTACTTGTCATGAATCATAT
AATCGAACATTTATGAAACTGGGACCAGAAGCTTTCAGATTTGATGGTGGTGTTGAAGCC
ATCGCTACAAGACAAAATGAAAAATACTACATCTTACGGCCAGAAGTTATGGAGACTTAC
ATGTATATGTGGAGACTGACTCATGATCCAAAGTACAGGAAATGGGCCTGGGAAGCCGTA
GAGGCCTTGGAAAACCATTGCAGAGTGAATGGAGGCTATTCAGGCCTAAGGGATGTTTAC
CTTCTTCATGAGAGTTATGATGATGTGCAGCAGAGTTTCTTCCTGGCAGAGACATTGAAA
TATTTGTACCTAATATTTTCTGACGACGATCTTCTTCCACTGGAGCATTGGATCTTCAAT
AGCGAGGCACATCTTCTCCCTATCCTCCCTAAAGATAAAAAGGAAGTTGAAATCAGAGAG
GAATAA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
AL022722

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_8_Locus:
6q22

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
14574404; 8223597

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5444

# Metabolic_Enzyme_9_Name:
Hexokinase-3

# Metabolic_Enzyme_9_Synonyms:
Hexokinase type III; HK III

# Metabolic_Enzyme_9_Gene_Name:
HK3

# Metabolic_Enzyme_9_Protein_Sequence:
>Hexokinase3
MDSIGSSGLRQGEETLSCSEEGLPGPSDSSELVQECLQQFKVTRAQLQQIQASLLGSMEQ
ALRGQASPAPAVRMLPTYVGSTPHGTEQGDFVVLELGATGASLRVLWVTLTGIEGHRVEP
RSQEFVIPQEVMLGAGQQLFDFAAHCLSEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRST
LISWTKGFRCSGVEGQDVVQLLRDAIRRQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVG
LVVDTGTNACYMEEARHVAVLDEDRGRVCVSVEWGSLSDDGALGPVLTTFDHTLDHESLN
PGAQRFEKMIGGLYLGELVRLVLAHLARCGVLFGGCTSPALLSQGSILLEHVAEMEDPST
GAARVHAILQDLGLSPGASDVELVQHVCAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQ
VAVATGGRVCERHPRFCSVLQGTVMLLAPECDVSLIPSVDGGGRGVAMVTAVAARLAAHR
RLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASSLRMLPTFVRATPDGSERGDFLA
LDLGGTNFRVLLVRVTTGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQ
SLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAI
VNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGD
DGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQ
RLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLC
GAGVAAVVEKIRGNRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSE
DGSGKGAALVTAVACRLAQLTRV

# Metabolic_Enzyme_9_Number_of_Residues:
923

# Metabolic_Enzyme_9_Molecular_Weight:
98921

# Metabolic_Enzyme_9_Theoretical_pI:
5.11

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_9_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism;
 map00521  Streptomycin biosynthesis;
 map00530  Aminosugars metabolism

# Metabolic_Enzyme_9_Reaction:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00349:Hexokinase_1;
PF03727:Hexokinase_2

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.7.1.1

# Metabolic_Enzyme_9_GenBank_ID_Protein:
1255788

# Metabolic_Enzyme_9_SwissProt_ID:
HXK3_HUMAN (P52790)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
HK3

# Metabolic_Enzyme_9_Geneatlas_id:
HK3

# Metabolic_Enzyme_9_hgnc_id:
HGNC:4925

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Not Available

# Metabolic_Enzyme_9_Gene_Sequence:
>2772 bp
ATGGACTCCATTGGGTCTTCAGGGTTGCGGCAGGGGGAAGAAACCCTGAGTTGCTCTGAG
GAGGGCTTGCCCGGGCCCTCAGACAGCTCAGAGCTGGTGCAGGAGTGCCTGCAGCAGTTC
AAGGTGACAAGGGCACAGCTACAGCAGATCCAAGCCAGCCTCTTGGGTTCCATGGAGCAG
GCGCTGAGGGGACAGGCCAGCCCTGCCCCTGCGGTCCGGATGCTGCCTACATACGTGGGG
TCCACCCCACATGGCACTGAGCAAGGAGACTTCGTGGTGCTGGAGCTGGGGGCCACAGGG
GCCTCACTGCGTGTTTTGTGGGTGACTCTAACTGGCATTGAGGGGCATAGGGTGGAGCCC
AGAAGCCAGGAGTTTGTGATCCCCCAAGAGGTGATGCTGGGTGCTGGCCAGCAGCTCTTT
GACTTTGCTGCCCACTGCCTGTCTGAGTTCCTGGATGCGCAGCCTGTGAACAAACAGGGT
CTGCAGCTTGGCTTCAGCTTCTCTTTCCCTTGTCACCAGACGGGCTTGGACAGGAGCACC
CTCATTTCCTGGACCAAAGGTTTTAGGTGCAGTGGTGTGGAAGGCCAGGATGTGGTCCAG
CTGCTGAGAGATGCCATTCGGAGGCAGGGGGCCTACAACATCGACGTGGTTGCTGTGGTG
AACGACACAGTGGGCACCATGATGGGCTGTGAGCCGGGGGTCAGGCCGTGTGAGGTTGGG
CTAGTTGTAGACACGGGCACCAACGCGTGTTACATGGAGGAGGCACGGCATGTGGCAGTG
CTGGACGAAGACCGGGGCCGCGTCTGCGTCAGCGTCGAGTGGGGCTCCTTAAGCGATGAT
GGGGCGCTGGGACCAGTGCTGACCACCTTCGACCATACCCTGGACCATGAGTCCCTGAAT
CCTGGTGCTCAGAGGTTTGAGAAGATGATCGGAGGCCTGTACCTGGGTGAGCTGGTGCGG
CTGGTGCTGGCTCACTTGGCCCGGTGTGGGGTCCTCTTTGGTGGCTGCACCTCCCCTGCC
CTGCTGAGCCAAGGCAGCATCCTCCTGGAACACGTGGCTGAGATGGAGGACCCCTCTACT
GGGGCAGCCCGTGTCCATGCTATCCTGCAGGACTTGGGCCTGAGCCCTGGGGCTTCGGAT
GTTGAGCTTGTGCAGCACGTCTGTGCGGCCGTGTGCACGCGGGCTGCCCAGCTCTGTGCT
GCCGCCCTGGCCGCTGTTCTCTCCTGCCTCCAGCACAGCCGGGAGCAACAAACACTCCAG
GTTGCTGTGGCCACCGGAGGCCGAGTGTGTGAGCGGCACCCCAGGTTCTGCAGCGTCCTG
CAGGGGACAGTGATGCTCCTGGCCCCGGAATGCGATGTCTCCTTAATCCCCTCTGTGGAT
GGTGGTGGCCGGGGAGTGGCGATGGTGACTGCTGTGGCTGCCCGTCTGGCTGCCCACCGG
CGCCTGCTGGAGGAGACCCTGGCCCCATTCCGGTTGAACCATGATCAACTGGCTGCGGTT
CAGGCACAGATGCGGAAGGCCATGGCCAAGGGGCTCCGAGGGGAGGCCTCCTCCCTTCGC
ATGCTGCCCACTTTCGTCCGGGCCACCCCTGACGGCAGCGAGCGAGGGGATTTCCTGGCC
CTGGACCTCGGGGGCACGAACTTCCGTGTCCTCCTGGTACGTGTGACCACAGGCGTGCAG
ATCACCAGCGAGATCTACTCCATTCCCGAGACTGTGGCCCAGGGTTCTGGGCAGCAGCTC
TTTGACCACATCGTGGACTGCATCGTGGACTTCCAGCAGAAGCAGGGCCTGAGCGGGCAG
AGCCTCCCACTGGGTTTTACCTTCTCCTTCCCATGTAGGCAGCTTGGCCTAGACCAGGGC
ATCCTCCTGAACTGGACCAAGGGTTTCAAGGCATCAGACTGCGAGGGCCAAGATGTCGTG
AGTCTGTTGCGGGAAGCCATCACTCGCAGACAGGCAGTGGAGCTGAATGTGGTTGCCATT
GTCAATGACACGGTGGGGACCATGATGTCCTGTGGCTATGAGGACCCCCGTTGCGAGATA
GGCCTCATTGTCGGAACCGGCACCAATGCCTGCTACATGGAGGAGCTCCGGAATGTGGCG
GGCGTGCCTGGGGACTCAGGCCGCATGTGCATCAACATGGAGTGGGGCGCCTTTGGGGAC
GATGGCTCTCTGGCCATGCTCAGCACCCGCTTTGATGCAAGTGTGGACCAGGCGTCCATC
AACCCCGGCAAGCAGAGGTTTGAAAAGATGATCAGCGGCATGTACCTGGGGGAGATCGTC
CGCCACATCCTTTTACATTTAACCAGCCTTGGCGTTCTCTTCCGGGGCCAGCAGATCCAG
CGCCTTCAGACCAGGGACATCTTCAAGACCAAGTTCCTCTCTGAGATCGAAAGTGACAGC
CTGGCCCTGCGGCAGGTCCGAGCCATCCTAGAGGATCTGGGGCTACCCCTGACCTCAGAT
GACGCCCTGATGGTGCTAGAGGTGTGCCAGGCTGTGTCCCAGAGGGCTGCCCAGCTCTGT
GGGGCGGGTGTAGCTGCCGTGGTGGAGAAGATCCGGGGGAACCGGGGCCTGGAAGAGCTG
GCAGTGTCTGTGGGGGTGGATGGAACGCTCTACAAGCTGCACCCGCGCTTCTCCAGCCTG
GTGGCGGCCACAGTGCGGGAGCTGGCCCCTCGCTGTGTGGTCACGTTCCTGCAGTCAGAG
GATGGGTCCGGCAAAGGTGCGGCCCTGGTCACCGCTGTTGCCTGCCGCCTTGCGCAGTTG
ACTCGTGTCTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
U51333

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_9_Locus:
5q35.2

# Metabolic_Enzyme_9_SNPs:
rs35610191; rs2278492; rs6875296; rs6861925; rs691141; rs691541; rs11135005; rs493578; rs691583; rs691057; rs522150; rs4976661; rs2278493; rs4976662; rs539822; rs691276; rs7716812; rs541807; rs12519232; rs479270; rs692200; rs10064961; rs3792729; rs12187462; rs691044; rs2278494; rs7736787; rs691693; rs691866; rs547798; rs3762971; rs812246; rs692129; rs2304514; rs35676647; rs34127573; rs494450; rs34497240; rs35226830; rs34468066; rs36002077; rs576380; rs34792080; rs36056969; rs6897020; rs35738781; rs4976631; rs35622796; rs4976663; rs691009; rs691473; rs34391089; rs3792730; rs35417166; rs691477; rs10056854; rs3762972; rs3762973; rs10543717; rs35180023; rs1043930; rs10475632; rs10475633; rs11953674; rs12422; rs1472920; rs2292255; rs2292256; rs2292257; rs2304515; rs2304516; rs2304517; rs2940531; rs2962835; rs2962844; rs2962845; rs3736431; rs3736432; rs3762974; rs475533; rs478253; rs490368; rs4976630; rs506370; rs690885; rs692011; rs9313744

# Metabolic_Enzyme_9_General_References:
8812439; 8717435

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
8094

# Metabolic_Enzyme_10_Name:
Ribonuclease H2 subunit A

# Metabolic_Enzyme_10_Synonyms:
RNase H2 subunit A; Ribonuclease HI subunit A; Ribonuclease HI large subunit; RNase HI large subunit; RNase H(35; Aicardi-Goutieres syndrome 4 protein; AGS4

# Metabolic_Enzyme_10_Gene_Name:
RNASEH2A

# Metabolic_Enzyme_10_Protein_Sequence:
>Ribonuclease H2 subunit 
AMDLSELERDNTGRCRLSSPVPAVCRKEPCVLGVDEAGRGPVLGPMVYAICYCPLPRLAD
LEALKVADSKTLLESERERLFAKMEDTDFVGWALDVLSPNLISTSMLGRVKYNLNSLSHD
TATGLIQYALDQGVNVTQVFVDTVGMPETYQARLQQSFPGIEVTVKAKADALYPVVSAAS
ICAKVARDQAVKKWQFVEKLQDLDTDYGSGYPNDPKTKAWLKEHVEPVFGFPQFVRFSWR
TAQTILEKEAEDVIWEDSASENQEGLRKITSYFLNEGSQARPRSSHRYFLERGLESATSL


# Metabolic_Enzyme_10_Number_of_Residues:
299

# Metabolic_Enzyme_10_Molecular_Weight:
33395

# Metabolic_Enzyme_10_Theoretical_pI:
4.88

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  RNA binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  nuclease activity
Function:  endonuclease activity
Function:  endoribonuclease activity
Function:  endoribonuclease activity, producing 5'-phosphomonoesters
Function:  ribonuclease H activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_10_Specific_Function:
Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes

# Metabolic_Enzyme_10_Pathway:
Not Available

# Metabolic_Enzyme_10_Reaction:
Endonucleolytic cleavage to 5'-phosphomonoester

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF01351:RNase_HII

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 3.1.26.4

# Metabolic_Enzyme_10_GenBank_ID_Protein:
3334761

# Metabolic_Enzyme_10_SwissProt_ID:
RNH2A_HUMAN (O75792)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
RNASEH2A

# Metabolic_Enzyme_10_Geneatlas_id:
RNASEH2A

# Metabolic_Enzyme_10_hgnc_id:
HGNC:18518

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Nucleus (Probable)

# Metabolic_Enzyme_10_Gene_Sequence:
>900 bp
ATGGATCTCAGCGAGCTGGAGAGAGACAATACAGGCCGCTGTCGCCTGAGTTCGCCTGTG
CCCGCGGTGTGCCGCAAGGAGCCTTGCGTCCTGGGCGTCGATGAGGCGGGCAGGGGCCCC
GTGCTGGGCCCCATGGTCTACGCCATCTGTTATTGTCCCCTGCCTCGCCTGGCAGATCTG
GAGGCGCTGAAAGTGGCAGACTCAAAGACCCTATTGGAGAGCGAGCGGGAAAGGCTGTTT
GCGAAAATGGAGGACACGGACTTTGTCGGCTGGGCGCTGGATGTGCTGTCTCCAAACCTC
ATCTCTACCAGCATGCTTGGGCGGGTCAAATACAACCTGAACTCCCTGTCACATGATACA
GCCACTGGGCTTATACAGTATGCATTGGACCAGGGCGTGAACGTCACCCAGGTATTCGTG
GACACCGTAGGGATGCCAGAGACATACCAGGCGCAGCTGCAGCAAAGTTTTCCCGGGATT
GAGGTGACGGTCAAGGCCAAAGCAGATGCCCTCTACCCGGTGGTTAGTGCTGCCAGCATC
TGTGCCAAGGTGGCCCGGGACCAGGCCGTGAAGAAATGGCAGTTCGTGGAGAAACTGCAG
GACTTGGATACTGATTATGGCTCAGGCTACCCCAATGATCCCAAGACAAAAGCGTGGTTG
AAGGAGCACGTGGAGCCTGTGTTCGGCTTCCCCCAGTTTGTCCGGTTCAGCTGGCGCACG
GCCCAGACCATCCTGGAGAAAGAGGCGGAAGATGTTATATGGGAGGACTCAGCATCCGAG
AATCAGGAGGGACTCAGGAAGATCACATCCTACTTCCTCAATGAAGGGTCCCAAGCCCGT
CCCCGTTCTTCCCACCGATATTTCCTGGAACGCGGCCTGGAGTCAGCAACCAGCCTCTAG


# Metabolic_Enzyme_10_GenBank_ID_Gene:
Z97029

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_10_Locus:
19p13.13

# Metabolic_Enzyme_10_SNPs:
rs7247284; rs15389; rs7257575; rs1046220; rs10421604; rs11882945; rs13345720; rs7247253; rs11879599; rs4804732; rs3786712; rs10418118; rs10409938; rs10407628; rs4804207; rs12461559; rs11554405; rs11554400; rs10409084; rs10421397; rs12610745; rs3786713; rs8111612; rs35557013; rs12609211; rs7254727; rs7251330; rs4804731; rs11879554; rs12610746; rs34860299; rs5827163; rs36051969; rs35741824; rs35486658; rs28577070; rs35756253; rs33961153; rs10405263; rs10407065; rs10413408; rs10422248; rs1056648; rs11671604; rs1205171; rs28603316; rs34187838; rs35501398; rs4804208; rs7254454; rs7507564; rs7508195; rs8107365

# Metabolic_Enzyme_10_General_References:
9789007

# Metabolic_Enzyme_10_References:
15190085; 15655798; 16461944; 17084089

# Metabolic_Enzyme_11_ID:
7789

# Metabolic_Enzyme_11_Name:
Hypothetical protein DKFZp434P174

# Metabolic_Enzyme_11_Synonyms:
Not Available

# Metabolic_Enzyme_11_Gene_Name:
DKFZp434P174

# Metabolic_Enzyme_11_Protein_Sequence:
>Hypothetical protein DKFZp434P174
AQFFRFDGWLINIENSLSLAAVGNMPPFLRYLTTQLHRQVPGGLVLWYDSVVQSGQLKWQ
DELNQHNRVFFDSCDGFFTNYNWREEHLERMLGQAGERRADVYVGVDVFARGNVVGGRFD
TDKVGGGFRPRASGPVPPLGPHFLMDLPFPSAPQRNDSSCSSQSGDPVALRNRCPAPAKL
CPH

# Metabolic_Enzyme_11_Number_of_Residues:
183

# Metabolic_Enzyme_11_Molecular_Weight:
20478

# Metabolic_Enzyme_11_Theoretical_pI:
7.50

# Metabolic_Enzyme_11_GO_Classification:
Not Available

# Metabolic_Enzyme_11_General_Function:
Not Available

# Metabolic_Enzyme_11_Specific_Function:
Not Available

# Metabolic_Enzyme_11_Pathway:
Not Available

# Metabolic_Enzyme_11_Reaction:
Not Available

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF03644:Glyco_hydro_85

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 3.2.1.96

# Metabolic_Enzyme_11_GenBank_ID_Protein:
52545543

# Metabolic_Enzyme_11_SwissProt_ID:
Q659F0_HUMAN (Q659F0)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
Not Available

# Metabolic_Enzyme_11_Geneatlas_id:
Not Available

# Metabolic_Enzyme_11_hgnc_id:
Not Available

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Not Available

# Metabolic_Enzyme_11_Gene_Sequence:
>552 bp
GCTCAGTTTTTTCGTTTTGATGGCTGGCTGATCAACATCGAGAACTCGCTGAGTCTGGCC
GCTGTGGGGAACATGCCTCCTTTCCTGCGGTACCTCACCACACAGCTGCACCGGCAGGTC
CCAGGGGGCCTGGTGCTCTGGTATGACAGCGTGGTGCAAAGTGGGCAGCTCAAATGGCAA
GACGAACTCAACCAGCACAACAGGGTCTTCTTTGATTCCTGCGACGGCTTCTTCACTAAC
TATAACTGGCGGGAGGAGCACTTGGAGCGGATGCTGGGGCAGGCTGGGGAGCGCCGGGCT
GATGTGTACGTGGGCGTGGATGTGTTTGCTCGAGGGAACGTGGTCGGAGGCCGATTCGAC
ACAGACAAGGTGGGTGGTGGCTTTCGTCCAAGGGCCAGCGGCCCAGTGCCTCCCCTGGGA
CCTCATTTCCTCATGGACCTTCCATTCCCGTCTGCACCTCAAAGGAATGACAGCAGCTGT
TCTTCCCAGAGTGGGGATCCCGTGGCACTGAGAAACAGGTGTCCTGCCCCGGCCAAGCTA
TGTCCCCACTGA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
AL110283

# Metabolic_Enzyme_11_Chromosome_Location:
Not Available

# Metabolic_Enzyme_11_Locus:
Not Available

# Metabolic_Enzyme_11_SNPs:
Not Available

# Metabolic_Enzyme_11_General_References:
Not Available

# Metabolic_Enzyme_11_References:
16232446; 16233259; 16343462

# Metabolic_Enzyme_12_ID:
8690

# Metabolic_Enzyme_12_Name:
Lysosomal alpha-mannosidase precursor

# Metabolic_Enzyme_12_Synonyms:
Mannosidase, alpha B; Lysosomal acid alpha-mannosidase; Laman; Mannosidase alpha class 2B member 1[Contains: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha- mannosidase E peptide]

# Metabolic_Enzyme_12_Gene_Name:
MAN2B1

# Metabolic_Enzyme_12_Protein_Sequence:
>Lysosomal alphamannosidase precursor
MGAYARASGVCARGCLDSAGPWTMSRALRPPLPPLCFFLLLLAAAGARAGGYETCPTVQP
NMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVE
IAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLE
DTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWR
ASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVA
TAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQAKGSSVHVLYSTPACYL
WELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVG
LAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNAL
ARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDP
NGRTVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRS
WSPALTIENEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAY
IFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIP
VGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNT
RIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRG
RHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSV
HLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQ
LREAASRLKWTTNTGPTPHQTPYQLDPANITLEPMEIRTFLASVQWKEVDG

# Metabolic_Enzyme_12_Number_of_Residues:
1011

# Metabolic_Enzyme_12_Molecular_Weight:
113745

# Metabolic_Enzyme_12_Theoretical_pI:
7.29

# Metabolic_Enzyme_12_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  mannosidase activity
Function:  alpha-mannosidase activity
 ||
>>>
 Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  mannose metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Carbohydrate transport and metabolism

# Metabolic_Enzyme_12_Specific_Function:
Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages

# Metabolic_Enzyme_12_Pathway:
map00511  N-Glycan degradation

# Metabolic_Enzyme_12_Reaction:
Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF09261:Alpha-mann_mid
PF01074:Glyco_hydro_38
PF07748:Glyco_hydro_38C

# Metabolic_Enzyme_12_Signals:
1-49

# Metabolic_Enzyme_12_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 3.2.1.24

# Metabolic_Enzyme_12_GenBank_ID_Protein:
1419374

# Metabolic_Enzyme_12_SwissProt_ID:
MA2B1_HUMAN (O00754)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
MAN2B1

# Metabolic_Enzyme_12_Geneatlas_id:
MAN2B1

# Metabolic_Enzyme_12_hgnc_id:
HGNC:6826

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_12_Gene_Sequence:
>2964 bp
ATGTCCCGCGCCCTGCGGCCACCGCTCCCGCCTCTCTGCTTTTTCCTTTTGTTGCTGGCG
GCTGCCGGTGCTCGGGCCGGGGGATACGAGACATGCCCCACAGTGCAGCCGAACATGCTG
AACGTGCACCTGCTGCCTCACACACATGATGACGTGGGCTGGCTCAAAACCGTGGACCAG
TACTTTTATGGAATCAAGAATGACATCCAGCACGCCGGTGTGCAGTACATCCTGGACTCG
GTCATCTCTGCCTTGCTGGCAGATCCCACCCGTCGCTTCATTTACGTGGAGATTGCCTTC
TTCTCCCGTTGGTGGCACCAGCAGACAAATGCCACACAGGAAGTCGTGCGAGACCTTGTG
CGCCAGGGGCGCCTGGAGTTCGCCAATGGTGGCTGGGTGATGAACGATGAGGCAGCCACC
CACTACGGTGCCATCGTGGACCAGATGACACTTGGGCTGCGCTTTCTGGAGGACACATTT
GGCAATGATGGGCGACCCCGTGTGGCCTGGCACATTGACCCCTTCGGCCACTCTCGGGAG
CAGGCCTCGCTGTTTGCGCAGATGGGCTTCGACGGCTTCTTCTTTGGGCGCCTTGATTAT
CAAGATAAGTGGGTACGGATGCAGAAGCTGGAGATGGAGCAGGTGTGGCGGGCCAGCACC
AGCCTGAAGCCCCCGACCGCGGACCTCTTCACTGGTGTGCTTCCCAATGGTTACAACCCG
CCAAGGAATCTGTGCTGGGATGTGCTGTGTGTCGATCAGCCGCTGGTGGAGGACCCTCGC
AGCCCCGAGTACAACGCCAAGGAGCTGGTCGATTACTTCCTAAATGTGGCCACTGCCCAG
GGCCGGTATTACCGCACCAACCACACTGTGATGACCATGGGCTCGGACTTCCAATATGAG
AATGCCAACATGTGGTTCAAGAACCTTGACAAGCTCATCCGGCTGGTAAATGCGCAGGCA
AAAGGAAGCAGTGTCCATGTTCTCTACTCCACCCCCGCTTGTTACCTCTGGGAGCTGAAC
AAGGCCAACCTCACCTGGTCAGTGAAACATGACGACTTCTTCCCTTACGCGGATGGCCCC
CACCAGTTCTGGACCGGTTACTTTTCCAGTCGGCCGGCCCTCAAACGCTACGAGCGCCTC
AGCTACAACTTCCTGCAGGTGTGCAACCAGCTGGAGGCGCTGGTGGGCCTGGCGGCCAAC
GTGGGACCCTATGGCTCCGGAGACAGTGCACCCCTCAATGAGGCGATGGCTGTGCTCCAG
CATCACGACGCCGTCAGCGGCACCTCCCGCCAGCACGTGGCCAACGACTACGCGCGCCAG
CTTGCGGCAGGCTGGGGGCCTTGCGAGGTTCTTCTGAGCAACGCGCTGGCGCGGCTCAGA
GGCTTCAAAGATCACTTCACCTTTTGCCAACAGCTAAACATCAGCATCTGCCCGCTCAGC
CAGACGGCGGCGCGCTTCCAGGTCATCGTTTATAATCCCCTGGGGCGGAAGGTGAATTGG
ATGGTACGGCTGCCGGTCAGCGAAGGCGTTTTCGTTGTGAAGGACCCCAATGGCAGGACA
GTGCCCAGCGATGTGGTAATATTTCCCAGCTCAGACAGCCAGGCGCACCCTCCGGAGCTG
CTGTTCTCAGCCTCACTGCCCGCCCTGGGCTTCAGCACCTATTCAGTAGCCCAGGTGCCT
CGCTGGAAGCCCCAGGCCCGCGCACCACAGCCCATCCCCAGAAGATCCTGGTCCCCTGCT
TTAACCATCGAAAATGAGCACATCCGGGCAACGTTTGATCCTGACACAGGGCTGTTGATG
GAGATTATGAACATGAATCAGCAACTCCTGCTGCCTGTTCGCCAGACCTTCTTCTGGTAC
AACGCCAGTATAGGTGACAACGAAAGTGACCAGGCCTCAGGTGCCTACATCTTCAGACCC
AACCAACAGAAACCGCTGCCTGTGAGCCGCTGGGCTCAGATCCACCTGGTGAAGACACCC
TTGGTGCAGGAGGTGCACCAGAACTTCTCAGCTTGGTGTTCCCAGGTGGTTCGCCTGTAC
CCAGGACAGCGGCACCTGGAGCTAGAGTGGTCGGTGGGGCCGATACCTGTGGGCGACACC
TGGGGGAAGGAGGTCATCAGCCGTTTTGACACACCGCTGGAGACAAAGGGACGCTTCTAC
ACAGACAGCAATGGCCGGGAGATCCTTGAGAGGAGGCGGGATTATCGACCCACCTGGAAA
CTGAACCAGACGGAGCCCGTGGCAGGAAACTACTATCCAGTCAACACCCGGATTTACATC
ACGGATGGAAACATGCAGCTGACTGTGCTGACTGACCGCTCCCAGGGGGGCAGCAGCCTG
AGAGATGGCTCGCTGGAGCTCATGGTGCACCGAAGGCTGCTGAAGGACGATGGACGCGGA
GTATCGGAGCCACTAATGGAGAACGGGTCGGGGGCGTGGGTGCGAGGGCGCCACCTGGTG
CTGCTGGACACAGCCCAGGCTGCAGCCGCCGGACACCGGCTCCTGGCGGAGCAGGAGGTC
CTGGCCCCTCAGGTGGTGCTGGCCCCGGGTGGCGGCGCCGCCTACAATCTCGGGGCTCCT
CCGCGCACGCAGTTCTCAGGGCTGCGCAGGGACCTGCCGCCCTCGGTGCACCTGCTCACG
CTGGCCAGCTGGGGCCCCGAAATGGTGCTGCTGCGCTTGGAGCACCAGTTTGCCGTAGGA
GAGGATTCCGGACGTAACCTGAGCGCCCCCGTTACCTTGAACTTGAGGGACCTGTTCTCC
ACCTTCACCATCACCCGCCTGCAGGAGACCACGCTGGTGGCCAACCAGCTCCGCGAGGCA
GCCTCCAGGCTCAAGTGGACAACAAACACAGGCCCCACACCCCACCAAACTCCGTACCAG
CTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATCCGCACTTTCCTGGCCTCAGTT
CAATGGAAGGAGGTGGATGGTTAG

# Metabolic_Enzyme_12_GenBank_ID_Gene:
U05572

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_12_Locus:
19cen-q13.1

# Metabolic_Enzyme_12_SNPs:
rs1054486; rs1054487; rs1133330; rs3745650; rs35836657; rs34544747; rs10410289; rs35880640; rs34246467; rs36037953; rs8107642; rs3815914; rs8107196; rs17476839; rs10415457; rs2303731; rs8102193; rs4804205; rs8104821; rs749920; rs8108316; rs10422318; rs11554969; rs11554970; rs28934600; rs3745649; rs35087690; rs34853569; rs36018312; rs34556863; rs35979808; rs35496970; rs34324185; rs10404858; rs13346980; rs35296973; rs12461275; rs28530601; rs10421764; rs8101980; rs35532533; rs28639634; rs1376645; rs12977242; rs10406375; rs33998995; rs10422663; rs28503705; rs1376644; rs8106147; rs34996464; rs34781385; rs12984441; rs28728275; rs10421864; rs10418260; rs13346580; rs28430845; rs34489442; rs2004492; rs2288452; rs35028647; rs35454423; rs35855049; rs10402068; rs1002339; rs10410027; rs10411504; rs10411619; rs10414810; rs1053292; rs1053805; rs1054367; rs12609451; rs14343; rs3178210; rs3209404; rs34203441; rs34373915; rs35092999; rs4575637; rs4804726; rs8110545; rs8112964

# Metabolic_Enzyme_12_General_References:
8166692; 9158146; 9192839; 8910458; 7832746; 12754519; 9758606; 9915946

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
8704

# Metabolic_Enzyme_13_Name:
Mannosidase, alpha, class 1C, member 1 variant

# Metabolic_Enzyme_13_Synonyms:
Not Available

# Metabolic_Enzyme_13_Gene_Name:
Not Available

# Metabolic_Enzyme_13_Protein_Sequence:
>Mannosidase, alpha, class 1C, member 1 variant
LRRTRPTGPREEATAARGNSIPASRPGDEGVPFRFDFNAFRSRLRHPVLGTRADESQEPQ
SQVRAQREKIKEMMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFGGLSGATVIDSLDTLY
LMELKEEFQEAKAWVGESFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEEVFRIKAIRLG
EKLLPAFNTPTGIPKGVVSFKSGNWGWATAGSSSILAEFGSLHLEFLHLTELSGNQVFAE
KVRNIRKVLRKIEKPFGLYPNFLSPVSGNWVQHHVSVGGLGDSFYEYLIKSWLMSGKTDM
EAKNMYYEALEAIETYLLNVSPGGLTYIAEWRGGILDHKMGHLACFSGGMIALGAEDAKE
EKRAHYRELAAQITKTCHESYARSDTKLGPEAFWFNSGREAVATQLSESYYILRPEVVES
YMYLWRQTHNPIYREWGWEVVLALEKYCRTEAGFSGIQDVYSSTPNHDNKQQSFFLAETL
KI

# Metabolic_Enzyme_13_Number_of_Residues:
482

# Metabolic_Enzyme_13_Molecular_Weight:
54542

# Metabolic_Enzyme_13_Theoretical_pI:
7.16

# Metabolic_Enzyme_13_GO_Classification:
>>>
 Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  mannosidase activity
Function:  mannosyl-oligosaccharide mannosidase activity
Function:  mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
Process:  protein amino acid N-linked glycosylation
 ||
>>>
 Component:  cell
Component:  membrane

# Metabolic_Enzyme_13_General_Function:
Not Available

# Metabolic_Enzyme_13_Specific_Function:
Not Available

# Metabolic_Enzyme_13_Pathway:
Not Available

# Metabolic_Enzyme_13_Reaction:
Not Available

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF01532:Glyco_hydro_47

# Metabolic_Enzyme_13_Signals:
Not Available

# Metabolic_Enzyme_13_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 3.2.1.113

# Metabolic_Enzyme_13_GenBank_ID_Protein:
62088130

# Metabolic_Enzyme_13_SwissProt_ID:
Q59G34_HUMAN (Q59G34)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
Not Available

# Metabolic_Enzyme_13_Geneatlas_id:
Not Available

# Metabolic_Enzyme_13_hgnc_id:
HGNC:19080

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_13_Gene_Sequence:
>1451 bp
GGCTGCGGCGCACCCGCCCCACTGGACCCCGCGAGGAGGCCACGGCGGCCCGGGGCAATA
GCATCCCGGCCTCCAGGCCCGGGGACGAGGGCGTCCCTTTCCGCTTTGACTTCAACGCAT
TCCGGAGCCGTCTCCGCCACCCGGTCCTGGGAACGAGGGCCGATGAGAGTCAGGAGCCCC
AGAGCCAAGTGCGAGCCCAGCGGGAGAAAATCAAGGAGATGATGCAGTTTGCTTGGCAGA
GCTATAAGCGTTATGCAATGGGGAAAAACGAACTCCGTCCACTAACAAAAGATGGCTACG
AGGGTAACATGTTCGGAGGCCTCAGCGGGGCAACAGTCATTGACTCCCTCGATACCCTCT
ACCTCATGGAGCTGAAGGAGGAGTTCCAGGAGGCCAAGGCCTGGGTGGGAGAGAGCTTCC
ACCTGAACGTGAGCGGAGAAGCATCCTTGTTTGAGGTGAACATCCGCTACATCGGGGGAC
TCCTCTCAGCCTTCTACCTGACAGGAGAAGAGGTGTTCCGAATAAAGGCCATCAGGCTGG
GAGAGAAGCTCCTGCCGGCGTTCAACACCCCCACGGGAATCCCAAAGGGCGTGGTGAGCT
TCAAAAGTGGGAACTGGGGCTGGGCCACAGCCGGCAGCAGCAGCATCTTGGCGGAGTTTG
GATCCCTGCACTTGGAATTCTTACACCTCACTGAACTCTCTGGCAACCAGGTCTTCGCTG
AAAAGGTCAGGAACATCCGCAAGGTCCTCAGGAAGATCGAAAAGCCCTTTGGCCTCTACC
CCAACTTCCTCAGCCCAGTGAGTGGGAACTGGGTGCAACACCATGTCTCAGTTGGAGGAC
TCGGGGACAGTTTTTATGAATATTTGATCAAATCCTGGTTGATGTCGGGCAAGACAGATA
TGGAGGCTAAAAATATGTACTACGAAGCCTTGGAGGCGATAGAGACCTACTTGCTGAATG
TCTCTCCCGGGGGGCTGACCTACATTGCCGAGTGGCGAGGGGGGATTCTGGACCACAAGA
TGGGGCACCTGGCCTGTTTCTCCGGGGGCATGATCGCCCTTGGCGCCGAGGATGCCAAGG
AAGAAAAGAGGGCCCACTACCGAGAGCTCGCAGCCCAGATCACCAAGACGTGTCACGAGT
CATACGCCCGCTCAGACACCAAACTTGGGCCTGAGGCCTTCTGGTTTAACTCCGGCAGAG
AGGCCGTGGCCACCCAGCTGAGCGAGAGCTACTACATCCTCCGGCCAGAGGTGGTGGAGA
GCTACATGTACCTGTGGCGACAGACCCACAACCCCATCTACAGGGAGTGGGGCTGGGAGG
TGGTGCTGGCCTTGGAGAAATACTGTCGGACAGAAGCCGGTTTCTCTGGGATCCAAGACG
TGTACAGTAGCACCCCCAACCACGACAACAAGCAGCAGAGCTTCTTTCTAGCGGAGACAC
TAAAGATTTGA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
AB209275

# Metabolic_Enzyme_13_Chromosome_Location:
Not Available

# Metabolic_Enzyme_13_Locus:
Not Available

# Metabolic_Enzyme_13_SNPs:
Not Available

# Metabolic_Enzyme_13_General_References:
Not Available

# Metabolic_Enzyme_13_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7555

# Macromolecular_Interacting_Partner_1_Name:
Fibronectin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
FN; Cold-insoluble globulin; CIG

# Macromolecular_Interacting_Partner_1_Gene_Name:
FN1

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Fibronectin precursor
MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQ
INQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMI
WDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCK
PIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSY
RIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHP
QPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPC
VLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTQGGNSNGALC
HFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRI
GDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHM
LNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQ
PLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIP
GHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSP
LVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDL
LPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITG
YRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTG
TPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNT
FAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWTPP
RAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATG
VFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVV
SGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTVSWERSTT
PDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPIS
DTIIPAVPPPTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSD
NAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIA
PRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLL
IGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSK
STATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISV
KWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGE
SQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAP
DGEEDTAELQGLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTDLKFTQVTPTSLSA
QWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLT
SRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANGQTPIQRT
IKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDASTAIDAPSNLRFLATTPNSLL
VSWQPPRARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ
KSEPLIGRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFVTHPGYDTGNGIQLPGTS
GQQPSVGQQMIFEEHGFRRTTPPTTATPIRHRPRPYPPNVGEEIQIGHIPREDVDYHLYP
HGPGLNPNASTGQEALSQTTISWAPFQDTSEYIISCHPVGTDEEPLQFRVPGTSTSATLT
GLTRGATYNIIVEALKDQQRHKVREEVVTVGNSVNEGLNQPTDDSCFDPYTVSHYAVGDE
WERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQMMSCTCLG
NGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGGEP
SPEGTTGQSYNQYSQRYHQRTNTNVNCPIECFMPLDVQADREDSRE

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
2386

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
262609

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.42

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00039:fn1;
PF00040:fn2;
PF00041:fn3

# Macromolecular_Interacting_Partner_1_Signals:
1-31

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
12053817

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
FINC_HUMAN (P02751)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
FN1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
FN1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:3778

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein; extracellular space; extracellular matrix

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1929 bp
ATGCTTAGGGGTCCGGGGCCCGGGCTGCTGCTGCTGGCCGTCCAGTGCCTGGGGACAGCG
GTGCCCTCCACGGGAGCCTCGAAGAGCAAGAGGCAGGCTCAGCAAATGGTTCAGCCCCAG
TCCCCGGTGGCTGTCAGTCAAAGCAAGCCCGGTTGTTATGACAATGGAAAACACTATCAG
ATAAATCAACAGTGGGAGCGGACCTACCTAGGCAATGCGTTGGTTTGTACTTGTTATGGA
GGAAGCCGAGGTTTTAACTGCGAGAGTAAACCTGAAGCTGAAGAGACTTGCTTTGACAAG
TACACTGGGAACACTTACCGAGTGGGTGACACTTATGAGCGTCCTAAAGACTCCATGATC
TGGGACTGTACCTGCATCGGGGCTGGGCGAGGGAGAATAAGCTGTACCATCGCAAACCGC
TGCCATGAAGGGGGTCAGTCCTACAAGATTGGTGACACCTGGAGGAGACCACATGAGACT
GGTGGTTACATGTTAGAGTGTGTGTGTCTTGGTAATGGAAAAGGAGAATGGACCTGCAAG
CCCATAGCTGAGAAGTGTTTTGATCATGCTGCTGGGACTTCCTATGTGGTCGGAGAAACG
TGGGAGAAGCCCTACCAAGGCTGGATGATGGTAGATTGTACTTGCCTGGGAGAAGGCAGC
GGACGCATCACTTGCACTTCTAGAAATAGATGCAACGATCAGGACACAAGGACATCCTAT
AGAATTGGAGACACCTGGAGCAAGAAGGATAATCGAGGAAACCTGCTCCAGTGCATCTGC
ACAGGCAACGGCCGAGGAGAGTGGAAGTGTGAGAGGCACACCTCTGTGCAGACCACATCG
AGCGGATCTGGCCCCTTCACCGATGTTCGTGCAGCTGTTTACCAACCGCAGCCTCACCCC
CAGCCTCCTCCCTATGGCCACTGTGTCACAGACAGTGGTGTGGTCTACTCTGTGGGGATG
CAGTGGCTGAAGACACAAGGAAATAAGCAAATGCTTTGCACGTGCCTGGGCAACGGAGTC
AGCTGCCAAGAGACAGCTGTAACCCAGACTTACGGTGGCAACTCAAATGGAGAGCCATGT
GTCTTACCATTCACCTACAACGACAGGACGGACAGCACAACTTCGAATTATGAGCAGGAC
CAGAAATACTCTTTCTGCACAGACCACACTGTTTTGGTTCAGACTCGAGGAGGAAATTCC
AATGGTGCCTTGTGCCACTTCCCCTTCCTATACAACAACCACAATTACACTGATTGCACT
TCTGAGGGCAGAAGAGACAACATGAAGTGGTGTGGGACCACACAGAACTATGATGCCGAC
CAGAAGTTTGGGTTCTGCCCCATGGCTGCCCACGAGGAAATCTGCACAACCAATGAAGGG
GTCATGTACCGCATTGGAGATCAGTGGGATAAGCAGCATGACATGGGTCACATGATGAGG
TGCACGTGTGTTGGGAATGGTCGTGGGGAATGGACATGCATTGCCTACTCGCAGCTTCGA
GATCAGTGCATTGTTGATGACATCACTTACAATGTGAACGACACATTCCACAAGCGTCAT
GAAGAGGGGCACATGCTGAACTGTACATGCTTCGGTCAGGGTCGGGGCAGGTGGAAGTGT
GATCCCGTCGACCAATGCCAGGATTCAGAGACTGGGACGTTTTATCAAATTGGAGATTCA
TGGGAGAAGTATGTGCATGGTGTCAGATACCAGTGCTACTGCTATGGCCGTGGCATTGGG
GAGTGGCATTGCCAACCTTTACAGACCTATCCAAGCTCAAGTGGTCCTGTCGAAGTATTT
ATCACTGAGACTCCGAGTCAGCCCAACTCCCACCCCATCCAGTGGAATGCACCACAGCCA
TCTCACATTTCCAAGTACATTCTCAGGTGGAGACCTGTGAGTATCCCACCCAGAAACCTT
GGATACTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AJ276395

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_1_Locus:
2q34

# Macromolecular_Interacting_Partner_1_SNPs:
rs6728999; rs17449032; rs1250259; rs1053238; rs7584505; rs13652; rs7596677; rs2289202; rs7589580; rs11651; rs34923683; rs1263; rs1264; rs1250215; rs1250270; rs2289199; rs1250249; rs2692228; rs1250250; rs1250238; rs724617; rs2888354; rs1250248; rs1250240; rs940739; rs1250239; rs1250241; rs1561301; rs1250210; rs1250269; rs7575234; rs1250268; rs7586990; rs10202483; rs10804242; rs7557114; rs7570208; rs1250203; rs1437799; rs2577290; rs7609476; rs6707530; rs10199059; rs1250242; rs2577297; rs1525351; rs7560662; rs6725958; rs2692230; rs7588661; rs1347694; rs7349218; rs2577302; rs1968510; rs12615520; rs10932613; rs6435906; rs1561302; rs13021377; rs6435903; rs7574485; rs6731557; rs1866155; rs1437798; rs1250204; rs6744921; rs7588830; rs10207245; rs7608342; rs2304573; rs7567647; rs4622720; rs6734955; rs1837121; rs2462591; rs13423742; rs3213885; rs13018173; rs13306359; rs2692234; rs10498037; rs7568287; rs1250247; rs1250245; rs940740; rs13432972; rs1975319; rs17517509; rs9288508; rs7560554; rs1250213; rs12466925; rs1898536; rs2577289; rs1437797; rs2289200; rs7594168; rs17457002; rs10172425; rs1250244; rs1437795; rs3796123; rs6709607; rs13004592; rs12105173; rs11693652; rs7575551; rs6435905; rs10498038; rs17457252; rs2372544; rs10201850; rs1250214; rs9288507; rs1250246; rs940738; rs11883812; rs7598634; rs17516906; rs2289198; rs13431081; rs1250258; rs1250201; rs17456939; rs2372545; rs4328631; rs1250243; rs1437796; rs13020766; rs2692224; rs13414859; rs1370561; rs12694363; rs2577298; rs10185587; rs17457029; rs1525352; rs1250211; rs17457391; rs11687442; rs12468524; rs17456054; rs3732355; rs2372542; rs17458018; rs16854055; rs10179882; rs6435904; rs16854041; rs13306373; rs13306365; rs7422428; rs10804241; rs11674123; rs3214671; rs2692223; rs13416478; rs16853839; rs7572169; rs1250212; rs7579867; rs13385786; rs2692227; rs1250256; rs10188325; rs7562453; rs13021679; rs1968509; rs6728950; rs7580800; rs12991003; rs11897708; rs12472383; rs6716361; rs1250264; rs17517928; rs34255697; rs7592898; rs33996776; rs1250267; rs6729052; rs17515300; rs7595740; rs7598545; rs12464459; rs2692222; rs11690611; rs16853986; rs7580569; rs13306364; rs11687611; rs1058361; rs1250209; rs13306372; rs34043251; rs2577301; rs28379061; rs11544109; rs2118413; rs11544105; rs34174607; rs11544106; rs6782; rs35223740; rs35151953; rs35525385; rs2692226; rs35343655; rs13394662; rs34228975; rs10605109; rs10170514; rs34300660; rs13008516; rs35292159; rs28464508; rs35819982; rs34685276; rs35762962; rs17514904; rs35800609; rs1063272; rs2028203; rs1250205; rs11367419; rs5838505; rs35913187; rs34978418; rs1250207; rs7556711; rs2438174; rs36086086; rs7422768; rs10203450; rs7598615; rs10599440; rs35126158; rs5838506; rs5838509; rs36097152; rs28564011; rs10181380; rs5838513; rs16853904; rs9749692; rs6743670; rs41347752; rs9751656; rs13026921; rs35976930; rs35034272; rs10534431; rs34066120; rs34085634; rs34576780; rs13017248; rs10648691; rs5838511; rs1250266; rs1968508; rs1250257; rs10542238; rs10559309; rs11897227; rs1250251; rs34656990; rs2577300; rs13306367; rs10168572; rs13394972; rs3832178; rs34162130; rs11889491; rs35639338; rs2372541; rs28631799; rs34087019; rs34317431; rs35609230; rs34325359; rs7606467; rs10179937; rs10202709; rs34595854; rs35492653; rs34345666; rs35754566; rs9751659; rs35780063; rs5838503; rs13431830; rs1313044; rs6729046; rs6727989; rs35233997; rs34645626; rs7565821; rs10524797; rs5838512; rs2438173; rs36098055; rs34156003; rs1250208; rs35545936; rs5838504; rs10648148; rs1250216; rs11411384; rs11376297; rs36066561; rs1250206; rs1250263; rs7556883; rs3051917; rs1250265; rs35437250; rs35258787; rs10679143; rs7558917; rs13306371; rs12621043; rs4393746; rs35494414; rs16853944; rs34173232; rs34314527; rs5838507; rs11358448; rs2177736; rs34245778; rs10649966; rs10614770; rs2577296; rs34947596; rs10577918; rs9751655; rs33963377; rs13306368; rs16853844; rs16853861; rs34147750; rs2372543; rs11315848; rs5838508; rs11350861; rs1437794; rs35440741; rs6712858; rs5838515; rs5838501; rs11897252; rs34140794; rs13427569; rs13015576; rs5838510; rs35967269; rs35143823; rs2289201; rs34196672; rs10611390; rs13001466; rs6738126; rs7562601; rs13409661; rs6738148; rs5838516; rs13023606; rs10599084; rs28365987; rs35118035; rs10180997; rs1250227; rs1250228; rs1250229; rs1250230; rs1250232; rs1250233; rs1250234; rs1250235; rs1250237; rs12999909; rs13027307; rs2577292; rs2692225; rs3910516; rs4473378; rs6706415; rs6725921; rs6735789; rs7562597; rs7588799; rs7596482; rs7604984

# Macromolecular_Interacting_Partner_1_General_References:
11737888; 3770189; 3031656; 2992939; 3900070; 6462919; 3375063; 2822387; 3478690; 7050098; 6688418; 3003095; 3593230; 2992573; 6200322; 3021206; 12127832; 2989004; 3770201; 4019516; 6304699; 6630202; 3024962; 2414772; 2012601; 1400330; 7989369; 9501082; 1311202; 1423622; 8308892; 7583666; 9514732; 10196121; 10647176; 11285216; 11775745; 12736686; 8120888; 8548820; 10075919

# Macromolecular_Interacting_Partner_1_References:
15236335; 16441238

# Macromolecular_Interacting_Partner_2_ID:
8147

# Macromolecular_Interacting_Partner_2_Name:
Mannose-binding protein C precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
MBP-C; MBP1; Mannan-binding protein; Mannose-binding lectin

# Macromolecular_Interacting_Partner_2_Gene_Name:
MBL2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Mannosebinding protein C precursor
MSLFPSLPLLLLSMVAASYSETVTCEDAQKTCPAVIACSSPGINGFPGKDGRDGTKGEKG
EPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGKSPDGDSSLAASERKALQTEMA
RIKKWLTFSLGKQVGNKFFLTNGEIMTFEKVKALCVKFQASVATPRNAAENGAIQNLIKE
EAFLGITDEKTEGQFVDLTGNRLTYTNWNEGEPNNAGSDEDCVLLLKNGQWNDVPCSTSH
LAVCEFPI

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
248

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
26144

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.14

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Binds mannose and N-acetylglucosamine in a calcium- dependent manner. Is capable of host defense against pathogens, by activating the classical complement pathway independently of the antibody

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF01391:Collagen;
PF00059:Lectin_C

# Macromolecular_Interacting_Partner_2_Signals:
1-20

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
34487

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
MBL2_HUMAN (P11226)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
MBL2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
MBL2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:6922

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>747 bp
ATGTCCCTGTTTCCATCACTCCCTCTCCTTCTCCTGAGTATGGTGGCAGCGTCTTACTCA
GAAACTGTGACCTGTGAGGATGCCCAAAAGACCTGCCCTGCAGTGATTGCCTGTAGCTCT
CCAGGCATCAACGGCTTCCCAGGCAAAGATGGGCGTGATGGCACCAAGGGAGAAAAGGGG
GAACCAGGCCAAGGGCTCAGAGGCTTACAGGGCCCCCCTGGAAAGTTGGGGCCTCCAGGA
AATCCAGGGCCTTCTGGGTCACCAGGACCAAAGGGCCAAAAAGGAGACCCTGGAAAAAGT
CCGGATGGTGATAGTAGCCTGGCTGCCTCAGAAAGAAAAGCTCTGCAAACAGAAATGGCA
CGTATCAAAAAGTGGCTGACCTTCTCTCTGGGCAAACAAGTTGGGAACAAGTTCTTCCTG
ACCAATGGTGAAATAATGACCTTTGAAAAAGTGAAGGCCTTGTGTGTCAAGTTCCAGGCC
TCTGTGGCCACCCCCAGGAATGCTGCAGAGAATGGAGCCATTCAGAATCTCATCAAGGAG
GAAGCCTTCCTGGGCATCACTGATGAGAAGACAGAAGGGCAGTTTGTGGATCTGACAGGA
AATAGACTGACCTACACAAACTGGAACGAGGGTGAACCCAACAATGCTGGTTCTGATGAA
GATTGTGTATTGCTACTGAAAAATGGCCAGTGGAATGACGTCCCCTGCTCCACCTCCCAT
CTGGCCGTCTGTGAGTTCCCTATCTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
X15422

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_2_Locus:
10q11.2-q21

# Macromolecular_Interacting_Partner_2_SNPs:
rs1800450; rs1800451; rs5030737; rs930507; rs35805975; rs10082466; rs2120132; rs2099903; rs2165813; rs2120131; rs11595876; rs2083771; rs2099902; rs10824792; rs2506; rs12254557; rs35768126; rs35327474; rs1838066; rs930509; rs1838065; rs10824793; rs930508; rs1982266; rs13312736; rs17334270; rs4935046; rs17287498; rs4935047; rs35520448; rs34800386; rs4647964; rs34519379; rs34650082; rs34390780; rs35175243; rs35137523; rs35829470; rs35260458; rs1982267; rs35094880; rs35406743; rs34077139; rs11003122; rs34610912; rs1899557; rs10450309; rs10824794; rs7095891; rs11003125; rs10824795; rs920724; rs7096206; rs16933335; rs11003124; rs7916582; rs920725; rs10450310; rs11593541; rs7100749; rs7084554; rs36014597; rs1899558; rs34787159; rs35236971; rs1031101; rs35615810; rs1899556; rs11003123; rs35779027; rs12240887; rs35668665; rs35331250; rs10556764; rs35451939; rs36040527; rs34313376; rs8191995; rs8191996; rs12260094; rs8179079; rs34120190; rs11003121; rs1042749; rs35937235; rs35648179; rs34180095; rs4647963; rs1126881; rs12255312; rs34130848; rs12250522; rs11575988; rs34148344; rs34584828; rs35410606; rs11575989; rs10508975; rs10740519; rs10740520; rs10740521; rs10740522; rs10762884; rs10824789; rs10824796; rs10824797; rs10824798; rs10824799; rs10824800; rs10824801; rs11003116; rs11003117; rs11003118; rs11003119; rs11003120; rs11003127; rs11003129; rs11003130; rs11003131; rs11003132; rs11003133; rs11003134; rs11003136; rs11003137; rs12221393; rs12251386; rs12254325; rs12263867; rs12264958; rs12360294; rs12771266; rs12784736; rs1373009; rs1443135; rs16933062; rs16933073; rs16933417; rs16933458; rs17664818; rs2165810; rs2384044; rs2384045; rs2384046; rs3829168; rs4935347; rs7071882; rs7098284; rs7476069; rs7899547; rs7902756; rs7916786; rs920727; rs930505; rs930506

# Macromolecular_Interacting_Partner_2_General_References:
2450948; 2477486; 2590164; 9743385; 7982896; 12175909; 9087411; 7634089; 1675710; 1304173; 1303250; 10447262

# Macromolecular_Interacting_Partner_2_References:
15336423

# Macromolecular_Interacting_Partner_3_ID:
7911

# Macromolecular_Interacting_Partner_3_Name:
Macrophage mannose receptor 1 precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
MMR; CD206 antigen

# Macromolecular_Interacting_Partner_3_Gene_Name:
MRC1

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Macrophage mannose receptor 1 precursor
MRLPLLLVFASVIPGAVLLLDTRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRW
VSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYG
NRQEKNIMLYKGSGLWSRWKIYGTTDNLCSRGYEAMYTLLGNANGATCAFPFKFENKWYA
DCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSESLWNKDPLTSVSYQINSKSALTW
HQARKSCQQQNAELLSITEIHEQTYLTGLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRY
LNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKKGNTTLNSFVIPSESDVPT
HCPSQWWPYAGHCYKIHRDEKKIQRDALTTCRKEGGDLTSIHTIEELDFIISQLGYEPND
ELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHENNRQEDCVVMKGKDGYWADRGCEW
PLGYICKMKSRSQGPEIVEVEKGCRKGWKKHHFYCYMIGHTLSTFAEANQTCNNENAYLT
TIEDRYEQAFLTSFVGLRPEKYFWTGLSDIQTKGTFQWTIEEEVRFTHWNSDMPGRKPGC
VAMRTGIAGGLWDVLKCDEKAKFVCKHWAEGVTHPPKPTTTPEPKCPEDWGASSRTSLCF
KLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYG
SPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPTMSWNDINCEHLNNWICQIQ
KGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQS
ESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCV
TMYSNSGFWNDINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIF
GFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTF
LWTDGRGVHYTNWGKGYPGGRRSSLSYEDADCVVIIGGASNEAGKWMDDTCDSKRGYICQ
TRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNA
FAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWK
TAHCNESFYFLCKRSDEIPATEPPQLPGRCPESDHTAWIPFHGHCYYIESSYTRNWGQAS
LECLRMGSSLVSIESAAESSFLSYRVEPLKSKTNFWIGLFRNVEGTWLWINNSPVSFVNW
NTGDPSGERNDCVALHASSGFWSNIHCSSYKGYICKRPKIIDAKPTHELLTTKADTRKMD
PSKPSSNVAGVVIIVILLILTGAGLAAYFFYKKRRVHLPQEGAFENTLYFNSQSSPGTSD
MKDLVGNIEQNEHSVI

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
1456

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
166012

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.50

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00040:fn2;
PF00059:Lectin_C;
PF00652:Ricin_B_lectin

# Macromolecular_Interacting_Partner_3_Signals:
1-18

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
1390-1410

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
188676

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
MRC1_HUMAN (P22897)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
MRC1

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
MRC1

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:7228

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>4371 bp
ATGAGGCTACCCCTGCTCCTGGTTTTTGCCTCTGTCATTCCGGGTGCTGTTCTCCTACTG
GACACCAGGCAATTTTTAATCTATAATGAAGATCACAAGCGCTGCGTGGATGCAGTGAGT
CCCAGTGCCGTCCAAACCGCAGCTTGCAACCAGGATGCCGAATCACAGAAATTCCGATGG
GTGTCCGAATCTCAGATTATGAGTGTTGCATTTAAATTATGCCTGGGAGTGCCATCAAAA
ACAGACTGGGTTGCTATCACTCTCTATGCCTGTGACTCAAAAAGTGAATTTCAGAAATGG
GAGTGCAAAAATGACACACTTTTGGGGATCAAAGGAGAAGATTTATTTTTTAACTACGGC
AACAGACAAGAAAAGAATATTATGCTCTACAAGGGATCGGGTTTATGGAGCAGGTGGAAG
ATCTATGGAACCACAGACAATCTGTGCTCCAGAGGTTATGAAGCCATGTATACGCTACTA
GGCAATGCCAATGGAGCAACCTGTGCATTCCCGTTCAAGTTTGAAAACAAGTGGTACGCA
GATTGCACGAGTGCTGGGCGGTCGGATGGATGGCTCTGGTGCGGAACCACTACTGACTAT
GACACAGACAAGCTATTTGGATATTGTCCATTGAAATTTGAGGGCAGTGAAAGCTTATGG
AATAAAGACCCGCTGACCAGCGTTTCCTACCAGATAAACTCCAAATCCGCTTTAACGTGG
CACCAAGCGAGGAAAAGCTGCCAACAACAGAACGCTGAGCTCCTGAGCATCACAGAGATA
CATGAGCAAACATACCTGACAGGATTAACCAGTTCCTTGACCTCAGGACTCTGGATTGGA
CTTAACAGTCTGAGCTTCAACAGCGGTTGGCAGTGGAGTGACCGCAGTCCTTTCCGATAT
TTGAACTGGTTACCAGGAAGTCCATCAGCTGAACCTGGAAAAAGCTGTGTGTCACTAAAT
CCTGGAAAAAATGCTAAATGGGAAAATCTGGAATGTGTTCAGAAACTGGGCTATATTTGC
AAAAAGGGCAACACCACTTTAAATTCTTTTGTTATTCCCTCAGAAAGTGATGTGCCTACT
CACTGTCCTAGTCAGTGGTGGCCGTATGCCGGTCACTGTTACAAGATTCACAGAGATGAG
AAAAAAATCCAGAGGGATGCTCTGACCACCTGCAGGAAGGAAGGCGGTGACCTCACAAGT
ATCCACACCATCGAGGAATTGGACTTTATTATCTCCCAGCTAGGATATGAGCCAAATGAC
GAATTGTGGATCGGCTTAAATGACATTAAGATTCAAATGTACTTTGAGTGGAGTGATGGG
ACCCCTGTAACGTTTACCAAATGGCTTCGTGGAGAACCAAGCCATGAAAACAACAGACAG
GAGGATTGTGTGGTGATGAAAGGCAAGGATGGGTACTGGGCAGATCGGGGCTGTGAGTGG
CCTCTTGGCTACATCTGCAAGATGAAATCACGAAGCCAAGGTCCAGAAATAGTGGAAGTC
GAAAAAGGCTGCAGGAAAGGCTGGAAAAAACATCACTTTTACTGCTATATGATTGGACAT
ACGCTTTCAACATTTGCAGAAGCAAACCAAACCTGTAATAATGAGAATGCTTATTTAACA
ACTATTGAAGACAGATATGAACAAGCCTTCCTGACTAGTTTCGTTGGCTTAAGGCCTGAA
AAATATTTCTGGACAGGACTTTCAGATATACAAACCAAAGGGACTTTTCAGTGGACCATC
GAGGAAGAGGTTCGGTTCACCCACTGGAATTCAGATATGCCAGGGCGAAAGCCAGGGTGT
GTTGCCATGAGAACCGGGATTGCAGGGGGCTTATGGGATGTTTTGAAATGTGATGAAAAG
GCAAAATTTGTGTGCAAGCACTGGGCAGAAGGAGTAACCCACCCACCGAAGCCCACGACG
ACTCCCGAACCCAAATGTCCGGAGGATTGGGGCGCCAGCAGTAGAACAAGCTTGTGTTTC
AAGCTGTATGCAAAAGGAAAACATGAGAAGAAAACGTGGTTTGAATCTCGAGATTTTTGT
CGAGCTCTGGGTGGAGACTTAGCTAGCATCAATAACAAAGAGGAACAGCAAACAATATGG
CGATTAATAACAGCTAGTGGAAGCTACCACAAACTGTTTTGGTTGGGATTGACATATGGA
AGCCCTTCAGAAGGTTTTACTTGGAGTGATGGTTCTCCTGTTTCATATGAAAACTGGGCT
TATGGAGAACCTAATAATTATCAAAATGTTGAATACTGTGGTGAGCTGAAAGGTGACCCT
ACTATGTCTTGGAATGATATTAATTGTGAACACCTTAACAACTGGATTTGCCAGATACAA
AAAGGACAAACACCAAAACCTGAGCCAACACCAGCTCCTCAAGACAATCCACCAGTTACT
GAAGATGGGTGGGTTATTTACAAAGACTACCAGTATTATTTCAGCAAAGAGAAGGAAACC
ATGGACAATGCGCGAGCGTTTTGCAAGAGGAATTTTGGTGATCTTGTTTCTATTCAAAGT
GAAAGTGAAAAGAAGTTTCTATGGAAATATGTAAACAGAAATGATGCACAGTCTGCATAT
TTTATTGGTTTATTGATCAGCTTGGATAAAAAGTTTGCTTGGATGGATGGAAGCAAAGTG
GATTACGTGTCTTGGGCCACAGGTGAACCCAATTTTGCAAATGAAGATGAAAACTGTGTG
ACCATGTATTCAAATTCAGGGTTTTGGAATGACATTAACTGTGGCTATCCAAACGCCTTC
ATTTGCCAGCGACATAACAGTAGTATCAATGCTACCACAGTTATGCCTACCATGCCCTCG
GTCCCATCAGGGTGCAAGGAAGGTTGGAATTTCTACAGCAACAAGTGTTTCAAAATCTTT
GGATTTATGGAAGAAGAAAGAAAAAATTGGCAAGAGGCACGAAAAGCTTGTATAGGCTTT
GGAGGGAATCTGGTCTCCATACAAAATGAAAAAGAGCAAGCATTTCTTACCTATCACATG
AAGGACTCCACTTTCAGTGCCTGGACTGGGCTGAATGATGTCAATTCAGAACACACGTTC
CTTTGGACGGATGGACGAGGAGTCCATTACACAAACTGGGGGAAAGGTTACCCTGGTGGA
AGAAGAAGCAGTCTTTCTTATGAAGATGCTGACTGTGTTGTTATTATTGGAGGTGCATCA
AATGAAGCAGGAAAATGGATGGATGATACCTGCGACAGTAAACGAGGCTACATATGCCAG
ACACGATCCGACCCTTCCTTGACTAATCCTCCAGCAACGATTCAAACAGATGGCTTTGTT
AAATATGGCAAAAGCAGCTATTCACTCATGAGACAAAAATTTCAATGGCATGAAGCGGAG
ACATACTGCAAGCTTCACAATTCCCTTATAGCCAGCATTCTGGATCCCTACAGTAATGCA
TTTGCGTGGCTGCAGATGGAAACATCTAATGAACGTGTGTGGATCGCCCTGAACAGTAAC
TTGACTGATAATCAATACACTTGGACTGATAAGTGGAGGGTGAGGTACACTAACTGGGCT
GCTGATGAGCCCAAATTGAAATCAGCATGTGTTTATCTGGATCTTGATGGCTACTGGAAG
ACAGCACATTGCAATGAAAGTTTTTACTTTCTCTGTAAAAGATCAGATGAAATCCCTGCT
ACTGAACCCCCACAACTGCCTGGCAGATGCCCGGAGTCAGATCACACAGCATGGATTCCT
TTCCATGGTCACTGTTACTATATTGAGTCCTCATATACAAGAAACTGGGGCCAAGCTTCT
CTGGAATGTCTTCGAATGGGTTCCTCTCTGGTTTCCATTGAAAGTGCTGCAGAATCCAGT
TTTCTGTCATATCGGGTTGAGCCACTTAAAAGTAAAACCAATTTTTGGATAGGATTGTTC
AGAAATGTTGAAGGGACGTGGCTGTGGATAAATAACAGTCCGGTCTCCTTTGTCAACTGG
AACACAGGAGATCCCTCTGGTGAACGGAATGATTGTGTAGCTTTACATGCGTCTTCTGGG
TTTTGGAGTAATATTCACTGTTCTTCCTACAAAGGATATATTTGTAAAAGACCAAAAATT
ATTGATGCTAAACCTACTCATGAATTACTTACAACAAAAGCTGACACAAGGAAGATGGAC
CCTTCTAAACCGTCTTCCAACGTGGCCGGAGTAGTCATCATTGTGATCCTCCTGATTTTA
ACGGGTGCTGGCCTTGCCGCCTATTTCTTTTATAAGAAAAGACGTGTGCACCTACCTCAA
GAGGGCGCCTTTGAAAACACTCTGTATTTTAACAGTCAGTCAAGCCCAGGAACTAGTGAT
ATGAAAGATCTCGTGGGCAATATTGAACAGAATGAACACTCGGTCATCTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
J05550

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_3_Locus:
10p12.33

# Macromolecular_Interacting_Partner_3_SNPs:
rs2461162; rs485104; rs482272; rs2477642; rs2477647; rs4748424; rs692719; rs35588459; rs2461161; rs692720; rs981; rs5783560; rs2477648; rs2461144; rs2461163; rs2477640; rs537085; rs2461146; rs2461147; rs2461165; rs11420374; rs35871419; rs2461148; rs12359178; rs691842; rs5783566; rs2246212; rs34965408; rs36121477; rs35668046; rs4747330; rs2947599; rs4748423; rs34673360; rs34814584; rs5783562; rs2461164; rs34260709; rs35586797; rs34037232; rs2477641; rs3740154; rs34881370; rs35469213; rs10692435; rs35480276; rs2461143; rs692409; rs692440

# Macromolecular_Interacting_Partner_3_General_References:
2373685; 1294118; 1730714; 10779515

# Macromolecular_Interacting_Partner_3_References:
16380916; 16731346; 16849611

# Macromolecular_Interacting_Partner_4_ID:
8392

# Macromolecular_Interacting_Partner_4_Name:
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase

# Macromolecular_Interacting_Partner_4_Synonyms:
N-acetylglucosaminyltransferase; I-branching enzyme; IGNT

# Macromolecular_Interacting_Partner_4_Gene_Name:
GCNT2

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Nacetyllactosaminide beta1,6Nacetylglucosaminyltransferase
MPLSMRYLFIISVSSVIIFIVFSVFNFGGDPSFQRLNISDPLRLTQVCTSFINGKTRFLW
KNKLMIHEKSSCKEYLTQSHYITAPLSKEEADFPLAYIMVIHHHFDTFARLFRAIYMPQN
IYCVHVDEKATTEFKDAVEQLLSCFPNAFLASKMEPVVYGGISRLQADLNCIRDLSAFEV
SWKYVINTCGQDFPLKTNKEIVQYLKGFKGKNITPGVLPPAHAIGRTKYVHQEHLGKELS
YVIRTTALKPPPPHNLTIYFGSAYVALSREFANFVLHDPRAVDLLQWSKDTFSPDEHFWV
TLNRIPGVPGSMPNASWTGNLRAIKWSDMEDRHGGCHGHYVHGICIYGNGDLKWLVNSPS
LFANKFELNTYPLTVECLELRHRERTLNQSETAIQPSWYF

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
400

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
45855

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.32

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  UDP-glycosyltransferase activity
Function:  acetylglucosaminyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells

# Macromolecular_Interacting_Partner_4_Pathway:
map00602  Blood group glycolipid biosynthesis-neolactoseries

# Macromolecular_Interacting_Partner_4_Reaction:
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF02485:Branch

# Macromolecular_Interacting_Partner_4_Signals:
1-23

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
EC 2.4.1.150

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
307298

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
GCNT2_HUMAN (Q06430)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
GCNT2

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
GCNT2

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:4204

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1203 bp
ATGCCTTTATCAATGCGTTACCTCTTCATAATTTCTGTCTCTAGTGTAATTATTTTTATC
GTCTTCTCTGTGTTCAATTTTGGGGGAGATCCAAGCTTCCAAAGGCTAAATATCTCAGAC
CCTTTGAGGCTGACTCAAGTTTGCACATCTTTTATCAATGGAAAAACACGTTTCCTGTGG
AAAAACAAACTAATGATCCATGAGAAGTCTTCTTGCAAGGAATACTTGACCCAGAGCCAC
TACATCACAGCCCCTTTATCTAAGGAAGAAGCTGACTTTCCCTTGGCATATATAATGGTC
ATCCATCATCACTTTGACACCTTTGCAAGGCTCTTCAGGGCTATTTACATGCCCCAAAAT
ATCTACTGTGTTCATGTGGATGAAAAAGCAACAACTGAATTTAAAGATGCGGTAGAGCAA
CTATTAAGCTGCTTCCCAAACGCTTTTCTGGCTTCCAAGATGGAACCCGTTGTCTATGGA
GGGATCTCCAGGCTCCAGGCTGACCTGAACTGCATCAGAGATCTTTCTGCCTTCGAGGTC
TCATGGAAGTACGTTATCAACACCTGTGGGCAAGACTTCCCCCTGAAAACCAACAAGGAA
ATAGTTCAGTATCTGAAAGGATTTAAAGGTAAAAATATCACCCCAGGGGTGCTGCCCCCA
GCTCATGCAATTGGACGGACTAAATATGTCCACCAAGAGCACCTGGGCAAAGAGCTTTCC
TATGTGATAAGAACAACAGCGTTGAAACCGCCTCCCCCCCATAATCTCACAATTTACTTT
GGCTCTGCCTATGTGGCTCTATCAAGAGAGTTTGCCAACTTTGTTCTGCATGACCCACGG
GCTGTTGATTTGCTCCAGTGGTCCAAGGACACTTTCAGTCCTGATGAGCATTTCTGGGTG
ACACTCAATAGGATTCCAGGTGTTCCTGGCTCTATGCCAAATGCATCCTGGACTGGAAAC
CTCAGAGCTATAAAGTGGAGTGACATGGAAGACAGACACGGAGGCTGCCACGGCCACTAT
GTACATGGTATTTGTATCTATGGAAACGGAGACTTAAAGTGGCTGGTTAATTCACCAAGC
CTGTTTGCTAACAAGTTTGAGCTTAATACCTACCCCCTTACTGTGGAATGCCTAGAACTG
AGGCATCGCGAAAGAACCCTCAATCAGAGTGAAACTGCGATACAACCCAGCTGGTATTTT
TGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
L19659

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_4_Locus:
6p24

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
8449405; 7579796; 9405606

# Macromolecular_Interacting_Partner_4_References:
15207699; 15351017; 15614444; 15938569

# Macromolecular_Interacting_Partner_5_ID:
7765

# Macromolecular_Interacting_Partner_5_Name:
Surfactant protein A

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
SPAR

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Surfactant protein 
AMTFKNNTTLSLFRLFNSFPLHKGYITTRELHQLALANLIFMFNCADLHFPPQMRKCFPI
PGTSCLFCPKTKTLFPVLHLANQYLCFLCQHKHCFPQTRFPDSQPSQATSRCVLSIKFTS
SIYINSHNYTLILTCIIVRVLCPPVGCKSYKDRGHIHLAHPSVPSTCHGSYQLTSTQYIV
WISKYDSNFQHPKLVYSPTEPAQVEHMQCFLCMCLQREEREALLLLPRVTILTRLSAEST
DERDGDSEPVNAVCRTALAFVPHESNVMLGIHNLLIWLL

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
278

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
31821

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
8.35

# Macromolecular_Interacting_Partner_5_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
402150

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
Q15509_HUMAN (Q15509)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
SPAR

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
SPAR

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:16351

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>837 bp
ATGACTTTTAAAAATAACACCACACTATCTCTATTTAGACTTTTCAACAGTTTCCCACTG
CACAAGGGATACATTACCACAAGGGAATTACACCAACTTGCCCTTGCAAATCTCATCTTT
ATGTTCAACTGTGCTGATCTTCATTTTCCTCCTCAGATGCGCAAATGCTTTCCCATCCCA
GGGACTTCATGTTTGTTCTGCCCCAAAACTAAAACACTCTTCCCTGTTCTTCATCTGGCT
AACCAATATTTGTGCTTTCTGTGTCAGCATAAACACTGTTTTCCTCAGACAAGATTTCCT
GACTCCCAGCCTAGCCAGGCCACTTCAAGGTGTGTGCTCTCCATAAAGTTTACTTCTTCT
ATATACATCAATTCACATAATTATACTTTAATACTTACTTGTATAATTGTTCGTGTGCTA
TGCCCCCCAGTTGGCTGTAAGTCCTATAAAGACAGAGGCCACATCCATCTTGCACATCCC
TCTGTTCCTAGCACCTGCCATGGGTCCTATCAGCTGACAAGCACTCAATATATTGTATGG
ATAAGTAAATATGATTCTAATTTCCAACATCCTAAACTTGTTTACAGTCCCACGGAGCCT
GCTCAGGTAGAGCACATGCAATGCTTCCTATGCATGTGTTTGCAGAGAGAAGAGAGAGAA
GCCCTTCTGCTTCTCCCACGTGTTACCATTTTGACCAGACTCAGTGCTGAAAGCACTGAT
GAAAGGGATGGAGACAGTGAGCCTGTGAATGCCGTGTGCAGAACAGCACTTGCCTTTGTC
CCCCATGAAAGTAATGTGATGCTCGGTATCCACAATCTTTTAATCTGGCTGCTGTAG

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
L10123

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_5_Locus:
4q31.21

# Macromolecular_Interacting_Partner_5_SNPs:
Not Available

# Macromolecular_Interacting_Partner_5_General_References:
8360162

# Macromolecular_Interacting_Partner_5_References:
15544801; 16548423; 16926403

# Macromolecular_Interacting_Partner_6_ID:
8167

# Macromolecular_Interacting_Partner_6_Name:
Pulmonary surfactant-associated protein A2 precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
SP-A2; SP-A; PSP-A; PSPA; Alveolar proteinosis protein; 35 kDa pulmonary surfactant-associated protein

# Macromolecular_Interacting_Partner_6_Gene_Name:
SFTPA2

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Pulmonary surfactantassociated protein A2 precursor
MWLCPLALNLILMAASGAACEVKDVCVGSPGIPGTPGSHGLPGRDGRDGVKGDPGPPGPM
GPPGETPCPPGNNGLPGAPGVPGERGEKGEAGERGPPGLPAHLDEELQATLHDFRHQILQ
TRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKK
YNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLY
SRLTICEF

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
248

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
26183

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
4.82

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF01391:Collagen;
PF00059:Lectin_C

# Macromolecular_Interacting_Partner_6_Signals:
1-20

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
190672

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
SFTA2_HUMAN (Q8IWL1)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SFTPA2

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SFTPA2

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:10799

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Secreted protein; extracellular space

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>747 bp
ATGTGGCTGTGCCCTCTGGCCCTCACCCTCATCTTGATGGCAGCCTCTGGTGCTGCGTGC
GAAGTGAAGGACGTTTGTGTTGGAAGCCCTGGTATCCCCGGCACTCCTGGATCCCACGGC
CTGCCAGGCAGGGACGGGAGAGATGGTGTCAAAGGAGACCCTGGCCCTCCAGGCCCCATG
GGTCCGCCTGGAGAAACACCATGTCCTCCTGGGAATAATGGGCTGCCTGGAGCCCCTGGT
GTCCCTGGAGAGCGTGGAGAGAAGGGGGAGCCTGGCGAGAGAGGCCCTCCAGGGCTTCCA
GCTCATCTAGATGAGGAGCTCCAAGCCACACTCCACGACTTCAGACATCAAATCCTGCAG
ACAAGGGGAGCCCTCAGTCTGCAGGGCTCCATAATGACAGTAGGAGAGAAGGTCTTCTCC
AGCAATGGGCAGTCCATCACTTTTGATGCCATTCAGGAGGCATGTGCCAGAGCAGGCGGC
CGCATTGCTGTCCCAAGGAATCCAGAGGAAAATGAGGCCATTGCAAGCTTCGTGAAGAAG
TACAACACATATGCCTATGTAGGCCTGACTGAGGGTCCCAGCCCTGGAGACTTCCGCTAC
TCAGATGGGACCCCTGTAAACTACACCAACTGGTACCGAGGGGAGCCTGCAGGTCGGGGA
AAAGAGCAGTGTGTGGAGATGTACACAGATGGGCAGTGGAATGACAGGAACTGCCTGTAC
TCCCGACTGACCATCTGTGAGTTCTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
K03475

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_6_Locus:
10q22-q23

# Macromolecular_Interacting_Partner_6_SNPs:
Not Available

# Macromolecular_Interacting_Partner_6_General_References:
3755136; 1372511

# Macromolecular_Interacting_Partner_6_References:
16548423; 16926403

# Macromolecular_Interacting_Partner_7_ID:
8383

# Macromolecular_Interacting_Partner_7_Name:
C-type lectin domain family 4 member F

# Macromolecular_Interacting_Partner_7_Synonyms:
C-type lectin superfamily member 13; C-type lectin 13

# Macromolecular_Interacting_Partner_7_Gene_Name:
CLEC4F

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Ctype lectin domain family 4 member 
FMDGEAVRFCTDNQCVSPHPQEVDSVAMAPAAPKIPRLVQATPAFMAVTLVFSLVTLFVV
VQQQTRPVPKPVQAVILGDNITGHLPFEPNNHHHFGREAEMRELIQTFKGHMENSSAWVV
EIQMLKCRVDNVNSQLQVLGDHLGNTNADIQMVKGVLKDATTLSLQTQMLRSSLEGTNAE
IQRLKEDLEKADALTFQTLNFLKSSLENTSIELHVLSRGLENANSEIQMLNASLETANTQ
AQLANSSLKNANAEIYVLRGHLDSVNDLRTQNQVLRNSLEGANAEIQGLKENLQNTNALN
SQTQAFIKSSFDNTSAEIQFLRGHLERAGDEIHVLKRDLKMVTAQTQKANGRLDQTDTQI
QVFKSEMENVNTLNAQIQVLNGHMKNASREIQTLKQGMKNASALTSQTQMLDSNLQKASA
EIQRLRGDLENTKALTMEIQQEQSRLKTLHVVITSQEQLQRTQSQLLQMVLQGWKFNGGS
LYYFSSVKKSWHEAEQFCVSQGAHLASVASKEEQAFLVEFTSKVYYWIGLTDRGTEGSWR


# Macromolecular_Interacting_Partner_7_Number_of_Residues:
539

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
60209

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.46

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Cell motility 

# Macromolecular_Interacting_Partner_7_Specific_Function:
Receptor with an affinity for galactose and fucose. Could be involved in endocytosis

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00059:Lectin_C

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
40-60

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
21755922

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
CLC4F_HUMAN (Q8N1N0)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
CLEC4F

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
CLEC4F

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:25357

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1620 bp
ATGGACGGTGAGGCAGTCCGCTTCTGCACAGATAACCAGTGTGTCTCCCCGCACCCCCAA
GAGGTGGACTCTGTGGCAATGGCTCCTGCAGCCCCCAAGATACCGAGGCTCGTTCAGGCT
ACCCCGGCATTTATGGCTGTGACCTTGGTCTTCTCTCTTGTGACTCTCTTTGTAGTGGTT
CAACAGCAGACAAGACCTGTTCCGAAGCCTGTGCAAGCCGTAATTCTGGGAGACAACATT
ACTGGGCATTTACCTTTTGAACCCAACAATCATCACCACTTTGGCAGGGAGGCAGAAATG
CGAGAGCTTATCCAGACATTTAAAGGCCACATGGAGAATTCCAGTGCCTGGGTAGTAGAA
ATCCAGATGTTGAAGTGCAGAGTGGACAATGTCAATTCGCAGCTCCAGGTGCTCGGTGAT
CATCTGGGAAACACCAATGCTGACATCCAGATGGTAAAAGGAGTTCTAAAGGATGCCACT
ACATTGAGTTTGCAGACACAGATGTTAAGGAGTTCCCTGGAGGGAACCAATGCTGAGATC
CAGAGGCTCAAGGAAGACCTTGAAAAGGCAGATGCTTTAACTTTCCAGACGCTGAATTTC
TTAAAAAGCAGTTTAGAAAACACCAGCATTGAGCTCCACGTGCTAAGCAGAGGCTTAGAA
AATGCAAACTCTGAAATTCAGATGTTGAATGCCAGTTTGGAAACGGCAAATACCCAGGCT
CAGTTAGCCAATAGCAGTTTAAAGAACGCTAATGCTGAGATCTATGTTTTGAGAGGCCAT
CTAGATAGTGTCAATGACTTGAGGACCCAGAACCAGGTTTTAAGAAATAGTTTGGAAGGA
GCCAATGCTGAGATCCAGGGACTAAAGGAAAATTTGCAGAACACAAATGCTTTAAACTCC
CAGACCCAGGCCTTTATAAAAAGCAGTTTTGACAACACTAGTGCTGAGATCCAGTTCTTA
AGAGGTCATTTGGAAAGAGCTGGTGATGAAATTCACGTGTTAAAAAGGGATTTGAAAATG
GTCACAGCCCAGACCCAAAAAGCAAATGGCCGTCTGGACCAGACAGATACTCAGATTCAG
GTATTCAAGTCAGAGATGGAAAATGTGAATACCTTAAATGCCCAGATTCAGGTCTTAAAT
GGTCATATGAAAAATGCCAGCAGAGAGATACAGACCCTAAAACAAGGAATGAAGAATGCT
TCAGCCTTAACTTCCCAGACCCAGATGTTAGACAGCAATCTGCAGAAGGCCAGTGCCGAG
ATCCAGAGGTTAAGAGGGGATCTAGAGAACACCAAAGCTCTAACCATGGAAATCCAGCAG
GAGCAGAGTCGCCTGAAGACCCTCCATGTGGTCATTACTTCACAGGAACAGCTACAAAGA
ACCCAAAGTCAGCTTCTCCAGATGGTCCTGCAAGGCTGGAAGTTCAATGGTGGAAGCTTA
TATTATTTTTCTAGTGTCAAGAAGTCTTGGCATGAGGCTGAGCAGTTCTGCGTGTCCCAG
GGAGCCCATCTGGCATCTGTGGCCTCCAAGGAGGAGCAGGCATTTCTGGTAGAGTTCACA
AGTAAAGTGTACTACTGGATCGGTCTCACTGACAGGGGCACAGAGGGCTCCTGGCGCTGA


# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
AK096429

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_7_Locus:
2p13.3

# Macromolecular_Interacting_Partner_7_SNPs:
rs722896; rs2075221; rs2287101; rs17006361; rs2287100; rs2075222; rs10181677; rs17656087; rs17656058; rs10181668; rs10184940; rs17006359; rs6710161; rs10175452; rs7419407; rs1548888; rs1548889; rs6749945; rs2902581; rs10198090; rs6749933; rs1548890; rs34875126; rs35001900; rs35381972; rs34318515; rs35637981; rs10178512; rs13035611; rs34855823; rs36077964; rs35483718; rs1861449; rs3217143; rs34067081; rs12611961; rs11546485; rs10199047; rs11677263; rs28412641; rs10208515; rs35788870; rs28785541; rs5832035; rs33969123; rs10185297; rs5832034; rs34800537; rs35936910; rs13030555; rs35932660; rs11894422; rs2080389; rs34256142; rs1005428; rs1005429; rs10168115; rs10192228; rs10193839; rs10198019; rs11126297; rs11126300; rs11684437; rs11684466; rs12991771; rs13015305; rs13015834; rs13389680; rs13389683; rs13412064; rs1544649; rs1544650; rs1544651; rs1544652; rs1544653; rs1544654; rs1548891; rs1548893; rs17006339; rs17656571; rs2075223; rs2075224; rs2110978; rs2863803; rs2863804; rs2863807; rs35856355; rs35893929; rs4852228; rs6546640; rs6712273; rs6715047; rs6725094; rs7560275; rs7575872; rs7575952; rs7586340; rs7587185; rs7587512

# Macromolecular_Interacting_Partner_7_General_References:
Not Available

# Macromolecular_Interacting_Partner_7_References:
15377434; 16056240; 16111657; 16547227

# Macromolecular_Interacting_Partner_8_ID:
8431

# Macromolecular_Interacting_Partner_8_Name:
C-type lectin domain family 4 member M

# Macromolecular_Interacting_Partner_8_Synonyms:
CD209 antigen-like protein 1; Dendritic cell-specific ICAM-3-grabbing nonintegrin 2; DC-SIGN2; DC-SIGN-related protein; DC-SIGNR; Liver/lymph node-specific ICAM- 3-grabbing nonintegrin; L-SIGN; CD299 antigen

# Macromolecular_Interacting_Partner_8_Gene_Name:
CLEC4M

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Ctype lectin domain family 4 member 
MMSDSKEPRVQQLGLLEEDPTTSGIRLFPRDFQFQQIHGHKSSTGCLGHGALVLQLLSFM
LLAGVLVAILVQVSKVPSSLSQEQSEQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQL
KAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQ
EIYQELTRLKAAVGELPEKSKLQEIYQELTELKAAVGELPEKSKLQEIYQELTQLKAAVG
ELPDQSKQQQIYQELTDLKTAFERLCRHCPKDWTFFQGNCYFMSNSQRNWHDSVTACQEV
RAQLVVIKTAEEQNFLQLQTSRSNRFSWMGLSDLNQEGTWQWVDGSPLSPSFQRYWNSGE
PNNSGNEDCAEFSGSGWNDNRCDVDNYWICKKPAACFRDE

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
399

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
45351

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
4.83

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Replication, recombination and repair 

# Macromolecular_Interacting_Partner_8_Specific_Function:
Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. Is presumably a coreceptor for the SARS coronavirus

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00059:Lectin_C

# Macromolecular_Interacting_Partner_8_Signals:
None

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
50-70

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
4586836

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
CLC4M_HUMAN (Q9H2X3)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
CLEC4M

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
CLEC4M

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:13523

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Isoform 1:Cell membrane; single-pass type II membrane protein (Potential). Isoform 2:Cell membrane; single- pass type II membrane protein (Potential). Isoform 3:Cell membrane; single-pass type II membrane protein (Potential). Isoform 5:Secreted protein (Potential). Isoform 6:Secreted protein (Potential). Isoform 7:Secreted protein (Potential). Isoform 10:Secreted protein (Potential)

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>891 bp
ATGAGTGACTCCAAGGAACCAAGGGTGCAGCAGCTGGGCCTCCTGGGGTGTCTTGGCCAT
GGCGCCCTGGTGCTGCAACTCCTCTCCTTCATGCTCTTGGCTGGGGTCCTGGTGGCCATC
CTTGTCCAAGTGTCCAAGGTCCCCAGCTCCCTAAGTCAGGAACAATCCGAGCAAGACGCA
ATCTACCAGAACCTGACCCAGCTTAAAGCTGCAGTGGGTGAGCTCTCAGAGAAATCCAAG
CTGCAGGAGATCTACCAGGAGCTGACCCAGCTGAAGGCTGCAGTGGGTGAGTTGCCAGAG
AAATCCAAGCTGCAGGAGATCTACCAGGAGCTGACCCGGCTGAAGGCTGCAGTGGGTGAG
TTGCCAGAGAAATCCAAGCTGCAGGAGATCTACCAGGAGCTGACCCGGCTGAAGGCTGCA
GTGGGTGAGTTGCCAGAGAAATCCAAGCTGCAGGAGATCTACCAGGAGCTGACCCGGCTG
AAGGCTGCAGTGGGTGAGTTGCCAGAGAAATCCAAGCTGCAGGAGATCTACCAGGAGCTG
ACGGAGCTGAAGGCTGCAGTGGGTGAGTTGCCAGAGAAATCCAAGCTGCAGGAGATCTAC
CAGGAGCTGACCCAGCTGAAGGCTGCAGTGGGTGAGTTGCCAGACCAGTCCAAGCAGCAG
CAAATCTATCAAGAACTGACCGATTTGAAGACTGCATTTGAACGCCTGTGCCGCCACTGT
CCCAAGGACTGGACATTCTTCCAAGGAAACTGTTACTTCATGTCTAACTCCCAGCGGAAC
TGGCACGACTCCGTCACCGCCTGCCAGGAAGTGAGGGCCCAGCTCGTCGTAATCAAAACT
GCTGAGGAGCAGCTTCCAGCGGTACTGGAACAGTGGAGAACCCAACAATAG

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
AB015629

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_8_Locus:
19p13

# Macromolecular_Interacting_Partner_8_SNPs:
rs2277998; rs11465376; rs479448; rs868878; rs1826305; rs868876; rs874492; rs557094; rs475896; rs2161525; rs868875; rs8113469; rs657855; rs562607; rs15282; rs1045998; rs3745376; rs558705; rs560634; rs8105492; rs1045997; rs12610506; rs655569; rs538442; rs12986314; rs594793; rs2335527; rs7245903; rs1826308; rs2335528; rs2287887; rs571497; rs488449; rs684388; rs7252764; rs11260029; rs7249298; rs12972830; rs11671490; rs28413926; rs12974851; rs12974848; rs35064548; rs12983590; rs12974835; rs12974826; rs12974857; rs9329374; rs1046000; rs1045996; rs1826306; rs12977324; rs12972166; rs12979429; rs582173; rs1826307; rs28447127; rs28676363; rs35342631; rs10411055; rs12462030; rs12974012; rs12982004; rs4804809; rs4804814; rs486664; rs517492; rs540303; rs565801; rs593535; rs593952; rs605673; rs608773; rs621025; rs653152; rs653488; rs7260351; rs807969; rs8111374

# Macromolecular_Interacting_Partner_8_General_References:
10072769; 10975799; 11257134

# Macromolecular_Interacting_Partner_8_References:
16603507

# Macromolecular_Interacting_Partner_9_ID:
8286

# Macromolecular_Interacting_Partner_9_Name:
CD209 antigen

# Macromolecular_Interacting_Partner_9_Synonyms:
Dendritic cell-specific ICAM-3-grabbing nonintegrin 1; DC-SIGN1; DC-SIGN; C-type lectin domain family 4 member L

# Macromolecular_Interacting_Partner_9_Gene_Name:
CD209

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>CD209 antigen
MSDSKEPRLQQLGLLEEEQLRGLGFRQTRGYKSLAGCLGHGPLVLQLLSFTLLAGLLVQV
SKVPSSISQEQSRQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKL
QEIYQELTRLKAAVGELPEKSKLQEIYQELTWLKAAVGELPEKSKMQEIYQELTRLKAAV
GELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQ
ELTQLKAAVERLCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQ
NFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFS
GNGWNDDKCNLAKFWICKKSAASCSRDEEQFLSPAPATPNPPPA

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
404

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
45775

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
5.16

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_9_General_Function:
Replication, recombination and repair 

# Macromolecular_Interacting_Partner_9_Specific_Function:
On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00059:Lectin_C

# Macromolecular_Interacting_Partner_9_Signals:
None

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
38-58

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
8572543

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
CD209_HUMAN (Q9NNX6)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
CD209

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
CD209

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:1641

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Isoform 1:Cell membrane; single-pass type II membrane protein (Probable). Isoform 2:Cell membrane; single- pass type II membrane protein (Probable). Isoform 3:Cell membrane; single-pass type II membrane protein (Probable). Isoform 4:Cell membrane; single-pass type II membrane protein (Probable). Isoform 5:Cell membrane; single-pass type II membrane protein (Probable). Isoform 6:Secreted protein (Probable). Isoform 7:Secreted protein (Probable). Isoform 8:Secreted protein (Probable). Isoform 9:Secreted protein (Probable). Isoform 10:Secreted protein (Probable). Isoform 11:Secreted protein (Probable). Isoform 12:Secreted protein (Probable)

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>1215 bp
ATGAGTGACTCCAAGGAACCAAGACTGCAGCAGCTGGGCCTCCTGGAGGAGGAACAGCTG
AGAGGCCTTGGATTCCGACAGACTCGAGGATACAAGAGCTTAGCAGGGTGTCTTGGCCAT
GGTCCCCTGGTGCTGCAACTCCTCTCCTTCACGCTCTTGGCTGGGCTCCTTGTCCAAGTG
TCCAAGGTCCCCAGCTCCATAAGTCAGGAACAATCCAGGCAAGACGCGATCTACCAGAAC
CTGACCCAGCTTAAAGCTGCAGTGGGTGAGCTCTCAGAGAAATCCAAGCTGCAGGAGATC
TACCAGGAGCTGACCCAGCTGAAGGCTGCAGTGGGTGAGCTTCCAGAGAAATCTAAGCTG
CAGGAGATCTACCAGGAGCTGACCCGGCTGAAGGCTGCAGTGGGTGAGCTTCCAGAGAAA
TCTAAGCTGCAGGAGATCTACCAGGAGCTGACCTGGCTGAAGGCTGCAGTGGGTGAGCTT
CCAGAGAAATCTAAGATGCAGGAGATCTACCAGGAGCTGACTCGGCTGAAGGCTGCAGTG
GGTGAGCTTCCAGAGAAATCTAAGCAGCAGGAGATCTACCAGGAGCTGACCCGGCTGAAG
GCTGCAGTGGGTGAGCTTCCAGAGAAATCTAAGCAGCAGGAGATCTACCAGGAGCTGACC
CGGCTGAAGGCTGCAGTGGGTGAGCTTCCAGAGAAATCTAAGCAGCAGGAGATCTACCAG
GAGCTGACCCAGCTGAAGGCTGCAGTGGAACGCCTGTGCCACCCCTGTCCCTGGGAATGG
ACATTCTTCCAAGGAAACTGTTACTTCATGTCTAACTCCCAGCGGAACTGGCACGACTCC
ATCACCGCCTGCAAAGAAGTGGGGGCCCAGCTCGTCGTAATCAAAAGTGCTGAGGAGCAG
AACTTCCTACAGCTGCAGTCTTCCAGAAGTAACCGCTTCACCTGGATGGGACTTTCAGAT
CTAAATCAGGAAGGCACGTGGCAATGGGTGGACGGCTCACCTCTGTTGCCCAGCTTCAAG
CAGTATTGGAACAGAGGAGAGCCCAACAACGTTGGGGAGGAAGACTGCGCGGAATTTAGT
GGCAATGGCTGGAACGACGACAAATGTAATCTTGCCAAATTCTGGATCTGCAAAAAGTCC
GCAGCCTCCTGCTCCAGGGATGAAGAACAGTTTCTTTCTCCAGCCCCTGCCACCCCAAAC
CCCCCTCCTGCGTAG

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
M98457

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_9_Locus:
19p13

# Macromolecular_Interacting_Partner_9_SNPs:
rs11465380; rs11465377; rs17159887; rs11465394; rs35545365; rs4804800; rs7248637; rs4804801; rs11465403; rs6603119; rs4804802; rs11260028; rs7248772; rs10403018; rs11465396; rs11465411; rs11465408; rs11465425; rs11465397; rs11465419; rs11465410; rs11465415; rs11465409; rs11465423; rs11465421; rs11465401; rs11465406; rs11465414; rs11465418; rs11465417; rs11465413; rs11465420; rs11465395; rs1544767; rs1544766; rs11465416; rs11465412; rs11465400; rs7252229; rs10410342; rs8105572; rs8105483; rs17159889; rs11465390; rs10422473; rs11465381; rs11465371; rs11465384; rs11465372; rs11465375; rs11465391; rs11465382; rs11465369; rs11465386; rs11465383; rs11465392; rs11465387; rs2287886; rs735239; rs4804803; rs7359874; rs735240; rs8112310; rs8101949; rs4804804; rs11465427; rs11260027; rs8112555; rs11465355; rs8111321; rs7254342; rs11465426; rs11465364; rs4804799; rs12610548; rs7248227; rs11465362; rs7258175; rs1981837; rs1981836; rs11465365; rs11465360; rs11465366; rs41374747; rs11465393; rs11465379; rs11465374; rs41335247; rs35552940; rs11465422; rs11465402; rs35705945; rs12460694; rs11465405; rs11465404; rs41382244; rs11465373; rs11465388; rs11465385; rs11465370; rs11465368; rs11465429; rs10417064; rs34472423; rs8112852; rs11465356; rs11465357; rs4045399; rs9749205; rs11465359; rs11465367; rs11465363; rs11465428; rs8109492; rs10409294; rs11881682; rs12611071; rs2431996; rs4804791; rs4804792; rs4804797; rs4804805; rs4804806; rs7250738

# Macromolecular_Interacting_Partner_9_General_References:
1518869; 10975799; 11257134

# Macromolecular_Interacting_Partner_9_References:
15308605; 15385553; 15481146; 16603507

# Macromolecular_Interacting_Partner_10_ID:
8661

# Macromolecular_Interacting_Partner_10_Name:
Solute carrier family 5

# Macromolecular_Interacting_Partner_10_Synonyms:
Sodium/glucose cotransporter, member 9

# Macromolecular_Interacting_Partner_10_Gene_Name:
SLC5A9

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Solute carrier family 5
MGPGASGDGVRTETAPHIALDSRVGLHAYDISVVVIYFVFVIAVGIWSSIRASRGTIGGY
FLAGRSMSWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEWNMRKSRSGGDRGIHP
RSHGRTGVRSQATWLLLALGWVFVPVYIAAGVVTMPQYLKKRFGGQRIQVYMSVLSLILY
IFTKISTDIFSGALFIQMALGWNLYLSTGILLVVTAVYTIAGGLMAVIYTDALQTVIMVG
GALVLMFLGFQDVGWYPGLEQRYRQAIPNVTVPNTTCHLPRPDAFHILRDPVSGDIPWPG
LIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRAL
FPDEVGCVDPDVCQRICGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIF
NSSSTLFTIDVWQRFRRKSTEQELMVVGRVFVVFLVVISILWIPIIQSSNSGQLFDYIQA
VTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRMILEFSYPAPACGEVDRRP
AVLKDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTRLTWWTRNCPLSELEKEAHES
TPEISERPAGECPAGGGAAENSSLGQEQPEAPSRSWGKLLWSWFCGLSGTPEQALSPAEK
AALEQKLTSIEEEPLWRHVCNINAVLLLAINIFLWGYFA

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
699

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
76101

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
8.16

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
 Function:  transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00474:SSF

# Macromolecular_Interacting_Partner_10_Signals:
1-150

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
28-50; 81-103; 131-153; 174-196; 206-228; 233-255; 296-313; 334-356; 402-424; 445-467; 477-499; 506-528; 548-570; 679-698

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
56203824

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
Q5TET3_HUMAN (Q5TET3)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
SLC5A9

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
SLC5A9

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:22146

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>2100 bp
ATGGGGCCTGGAGCTTCAGGGGACGGGGTCAGGACTGAGACAGCTCCACACATAGCACTG
GACTCCAGAGTTGGTCTGCACGCCTACGACATCAGCGTGGTGGTCATCTACTTTGTCTTC
GTCATTGCTGTGGGGATCTGGTCGTCCATCCGTGCAAGTCGAGGGACCATTGGCGGCTAT
TTCCTGGCCGGGAGGTCCATGAGCTGGTGGCCAATTGGAGCATCTCTGATGTCCAGCAAT
GTGGGCAGTGGCTTGTTCATCGGCCTGGCTGGGACAGGGGCTGCCGGAGGCCTTGCCGTA
GGTGGCTTCGAGTGGAACATGAGGAAATCAAGGTCTGGAGGAGACAGAGGGATCCATCCA
AGGTCACACGGGAGGACTGGGGTCAGGTCCCAGGCAACCTGGCTGCTCCTGGCCCTTGGC
TGGGTCTTCGTCCCTGTGTACATCGCAGCAGGTGTGGTCACAATGCCGCAGTATCTGAAG
AAGCGATTTGGGGGCCAGAGGATCCAGGTGTACATGTCTGTCCTGTCTCTCATCCTCTAC
ATCTTCACCAAGATCTCGACTGACATCTTCTCTGGAGCCCTCTTCATCCAGATGGCATTG
GGCTGGAACCTGTACCTCTCCACAGGGATCCTGCTGGTGGTGACTGCCGTCTACACCATT
GCAGGTGGCCTCATGGCCGTGATCTACACAGATGCTCTGCAGACGGTGATCATGGTAGGG
GGAGCCCTGGTCCTCATGTTTCTGGGCTTTCAGGACGTGGGCTGGTACCCAGGCCTGGAG
CAGCGGTACAGGCAGGCCATCCCTAATGTCACAGTCCCCAACACCACCTGTCACCTCCCA
CGGCCCGATGCTTTCCACATTCTTCGGGACCCTGTGAGCGGGGACATCCCTTGGCCAGGT
CTCATTTTCGGGCTCACAGTGCTGGCCACCTGGTGTTGGTGCACAGACCAGGTCATTGTG
CAGCGGTCTCTCTCGGCCAAGAGTCTGTCTCATGCCAAGGGAGGCTCCGTGCTGGGGGGC
TACCTGAAGATCCTCCCCATGTTCTTCATCGTCATGCCTGGCATGATCAGCCGGGCCCTG
TTCCCAGACGAGGTGGGCTGCGTGGACCCTGATGTCTGCCAAAGAATCTGTGGGGCCCGA
GTGGGATGTTCCAACATTGCCTACCCTAAGTTGGTCATGGCCCTCATGCCTGTTGGTCTG
CGGGGGCTGATGATTGCCGTGATCATGGCCGCTCTCATGAGCTCACTCACCTCCATCTTC
AACAGCAGCAGCACCCTGTTCACCATTGATGTGTGGCAGCGCTTCCGCAGGAAGTCAACA
GAGCAGGAGCTGATGGTGGTGGGCAGAGTGTTTGTGGTGTTCCTGGTTGTCATCAGCATC
CTCTGGATCCCCATCATCCAAAGCTCCAACAGTGGGCAGCTCTTCGACTACATCCAGGCT
GTCACCAGTTACCTGGCCCCACCCATCACCGCTCTCTTCCTGCTGGCCATCTTCTGCAAG
AGGGTCACAGAGCCCGGAGCTTTCTGGGGCCTCGTGTTTGGCCTGGGAGTGGGGCTTCTG
CGTATGATCCTGGAGTTCTCATACCCAGCGCCAGCCTGTGGGGAGGTGGACCGGAGGCCA
GCAGTGCTGAAGGACTTCCACTACCTGTACTTTGCAATCCTCCTCTGCGGGCTCACTGCC
ATCGTCATTGTCATTGTCAGCCTCTGTACAACTCCCATCCCTGAGGAACAGCTCACACGC
CTCACATGGTGGACTCGGAACTGCCCCCTCTCTGAGCTGGAGAAGGAGGCCCACGAGAGC
ACACCGGAGATATCCGAGAGGCCAGCCGGGGAGTGCCCTGCAGGAGGTGGAGCGGCAGAG
AACTCGAGCCTGGGCCAGGAGCAGCCTGAAGCCCCAAGCAGGTCCTGGGGAAAGTTGCTC
TGGAGCTGGTTCTGTGGGCTCTCTGGAACACCGGAGCAGGCCCTGAGCCCAGCAGAGAAG
GCTGCGCTAGAACAGAAGCTGACAAGCATTGAGGAGGAGCCACTCTGGAGACATGTCTGC
AACATCAATGCTGTCCTTTTGCTGGCCATCAACATCTTCCTCTGGGGCTATTTTGCGTGA


# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
AL109659

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_10_Locus:
1p33

# Macromolecular_Interacting_Partner_10_SNPs:
rs850763; rs212989; rs12047252; rs212991; rs986027; rs2275698; rs1005538; rs2137831; rs4926518; rs11205458; rs11205459; rs764656; rs4926721; rs6670286; rs10788884; rs540944; rs12139099; rs4926720; rs12043455; rs12563106; rs7413497; rs6685450; rs11807747; rs2354005; rs1004833; rs705430; rs11809119; rs10888600; rs12126047; rs12118417; rs11205460; rs10489600; rs6694372; rs17104309; rs172480; rs212987; rs212986; rs6695408; rs12040115; rs12161316; rs7535096; rs41287930; rs41287932; rs17104299; rs12069452; rs12744691; rs11800306; rs36026942; rs28559882; rs12744574; rs35442116; rs177111; rs12123480; rs5773996; rs28548080; rs12119362; rs12130095; rs12081921; rs34216216; rs7554493; rs28637099; rs41287918; rs34855469; rs12738451; rs7415392; rs36053829; rs483937; rs1524734; rs12161552; rs5773999; rs28380281; rs35238707; rs7556499; rs34463054; rs35278010; rs35274475; rs41341650; rs28495806; rs5773998; rs212990; rs212988; rs35687593; rs34525597; rs7413495; rs35719528; rs34762012; rs12746335; rs41287922; rs12039311; rs34370455; rs34004627; rs212972; rs11205461; rs12026864; rs34445433; rs212984; rs212985; rs12746902; rs6695277; rs10430109; rs41287916; rs34039663; rs10788883; rs11205457; rs11802676; rs12081912; rs12120330; rs12739960; rs1524732; rs169880; rs1740106; rs1740107; rs212959; rs212961; rs212962; rs212963; rs212964; rs212965; rs212966; rs212970; rs2354002; rs490631; rs4926722; rs542281; rs550663; rs579416; rs705429; rs705432; rs850761; rs910621; rs926979; rs960721; rs960722

# Macromolecular_Interacting_Partner_10_General_References:
Not Available

# Macromolecular_Interacting_Partner_10_References:
Not Available

# Macromolecular_Interacting_Partner_11_ID:
8696

# Macromolecular_Interacting_Partner_11_Name:
Hexokinase domain containing 1

# Macromolecular_Interacting_Partner_11_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_11_Gene_Name:
HKDC1

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Hexokinase domain containing 1
MFAVHLMAFYFSKLKEDQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAA
VKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIR
GNGTELFEYVADCLADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGV
QDTDVVSRLTKAMRRHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYME
DMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGL
YLGELVRLILLKMAKAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLG
LEPSEADCIAVQHVCTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIH
PQYPKRLHKVVRKLVPSCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLT
REQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRV
LLVKIRSGRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFT
FSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGT
MMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDI
WTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGI
FETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAI
VEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGA
ALITAVAKRLQQAQKEN

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
917

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
102546

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
7.12

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
 Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_11_General_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF00349:Hexokinase_1
PF03727:Hexokinase_2

# Macromolecular_Interacting_Partner_11_Signals:
Not Available

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
55665502

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
Q5VTC7_HUMAN (Q5VTC7)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
HKDC1

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
HKDC1

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:23302

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>2754 bp
ATGTTTGCGGTCCACTTGATGGCATTTTACTTCAGCAAGCTGAAGGAGGACCAGATCAAG
AAGGTGGACAGGTTCCTGTATCACATGCGGCTCTCCGATGACACCCTTTTGGACATCATG
AGGCGGTTCCGGGCTGAGATGGAGAAGGGCCTGGCAAAGGACACCAACCCCACGGCTGCA
GTGAAGATGTTGCCCACCTTCGTCAGGGCCATTCCCGATGGTTCCGAAAATGGGGAGTTC
CTTTCCCTGGATCTCGGAGGGTCCAAGTTCCGAGTGCTGAAGGTGCAAGTCGCTGAAGAG
GGGAAGCGACACGTGCAGATGGAGAGTCAGTTCTACCCAACGCCCAATGAAATCATCCGC
GGGAACGGCACAGAGCTGTTTGAATATGTAGCTGACTGTCTGGCAGATTTCATGAAGACC
AAAGATTTAAAGCATAAGAAATTGCCCCTTGGCCTAACTTTTTCTTTCCCCTGTCGACAG
ACTAAACTGGAAGAGGGTGTCCTACTTTCGTGGACAAAAAAGTTTAAGGCACGAGGAGTT
CAGGACACGGATGTGGTGAGCCGTCTGACCAAAGCCATGAGAAGACACAAGGACATGGAC
GTGGACATCCTGGCCCTGGTCAATGACACCGTGGGGACCATGATGACCTGTGCCTATGAC
GACCCCTACTGCGAAGTTGGTGTCATCATCGGAACTGGCACCAATGCGTGTTACATGGAG
GACATGAGCAACATTGACCTGGTGGAGGGCGACGAGGGCAGGATGTGCATCAACACAGAG
TGGGGGGCCTTCGGGGACGACGGGGCCCTGGAGGACATTCGCACTGAGTTCGACAGGGAG
CTGGACCTCGGCTCTCTCAACCCAGGAAAGCAACTGTTCGAGAAGATGATCAGTGGCCTG
TACCTGGGGGAGCTTGTCAGGCTTATCTTGCTGAAGATGGCCAAGGCTGGCCTCCTGTTT
GGTGGTGAGAAATCTTCTGCTCTCCACACTAAGGGCAAGATCGAAACACGGCACGTGGCT
GCCATGGAGAAGTATAAAGAAGGCCTTGCTAATACAAGAGAGATCCTGGTGGACCTGGGT
CTGGAACCGTCTGAGGCTGACTGCATTGCCGTCCAGCATGTCTGTACCATCGTCTCCTTC
CGCTCGGCCAATCTCTGTGCAGCAGCTCTGGCGGCCATCCTGACACGCCTCCGGGAGAAC
AAGAAGGTGGAACGGCTCCGGACCACAGTGGGCATGGACGGCACCCTCTACAAGATACAC
CCTCAGTACCCAAAACGCCTGCACAAGGTGGTGAGGAAACTGGTCCCAAGCTGTGATGTC
CGCTTCCTCCTGTCAGAGAGTGGCAGCACCAAGGGGGCCGCCATGGTGACCGCGGTGGCC
TCCCGCGTGCAGGCCCAGCGGAAGCAGATCGACAGGGTGCTGGCTTTGTTCCAGCTGACC
CGAGAGCAGCTCGTGGACGTGCAGGCCAAGATGCGGGCTGAGCTGGAGTATGGGCTGAAG
AAGAAGAGCCACGGGCTGGCCACGGTCAGGATGCTGCCCACCTACGTCTGCGGGCTGCCG
GACGGCACAGAGAAAGGAAAGTTTCTCGCCCTGGATCTTGGGGGAACCAACTTCCGGGTC
CTCCTGGTGAAGATCAGAAGTGGACGGAGGTCAGTGCGAATGTACAACAAGATCTTCGCC
ATCCCCCTGGAGATCATGCAGGGCACTGGTGAGGAGCTCTTTGATCACATTGTGCAGTGC
ATCGCCGACTTCCTGGACTACATGGGCCTCAAGGGAGCCTCCCTACCTTTGGGCTTCACA
TTCTCATTTCCCTGCAGGCAGATGAGCATTGACAAGGGAACACTCATAGGGTGGACCAAA
GGTTTCAAGGCCACTGACTGTGAAGGGGAGGACGTGGTGGACATGCTCAGGGAAGCCATC
AAGAGGAGAAACGAGTTTGACCTGGACATTGTTGCAGTCGTGAATGATACAGTGGGGACC
ATGATGACCTGTGGCTATGAAGATCCTAATTGTGAGATTGGCCTGATTGCAGGAACAGGC
AGCAACATGTGCTACATGGAGGACATGAGGAACATCGAGATGGTGGAGGGGGGTGAAGGG
AAGATGTGCATCAATACAGAGTGGGGAGGATTTGGAGACAATGGCTGCATAGATGACATC
TGGACCCGATACGACACGGAGGTGGATGAGGGGTCCTTGAATCCTGGCAAGCAGAGATAC
GAGAAAATGACCAGTGGGATGTACTTGGGGGAGATTGTGCGGCAGATCCTGATCGACCTG
ACCAAGCAGGGTCTCCTCTTCCGAGGGCAGATTTCAGAGCGTCTCCGGACCAGGGGCATC
TTCGAAACCAAGTTCCTGTCCCAGATCGAAAGCGATCGGCTGGCCCTTCTCCAGGTCAGG
AGGATTCTGCAGCAGCTGGGCCTGGACAGCACGTGTGAGGACAGCATCGTGGTGAAGGAG
GTGTGCGGAGCCGTGTCCCGGCGGGCGGCCCAGCTCTGCGGTGCTGGCCTGGCCGCTATA
GTGGAAAAAAGGAGAGAAGACCAGGGGCTAGAGCACCTGAGGATCACTGTGGGTGTGGAC
GGCACCCTGTACAAGCTGCACCCTCACTTTTCTAGAATATTGCAGGAAACTGTGAAGGAA
CTAGCCCCTCGATGTGATGTGACATTCATGCTGTCAGAAGATGGCAGTGGAAAAGGGGCA
GCACTGATCACTGCTGTGGCCAAGAGGTTACAGCAGGCACAGAAGGAGAACTAG

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
AL596223

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_11_Locus:
10q21.3

# Macromolecular_Interacting_Partner_11_SNPs:
rs906219; rs874556; rs7899445; rs10823320; rs1111335; rs5030948; rs2611; rs4746832; rs3740601; rs1472814; rs2102339; rs874557; rs7089312; rs5030946; rs10998677; rs7075720; rs5030971; rs4145930; rs7904936; rs4746825; rs5030972; rs2394529; rs953724; rs10762268; rs4746828; rs5030944; rs2279927; rs5030970; rs1983128; rs7923953; rs7918272; rs925024; rs4746823; rs10823322; rs10998673; rs4072135; rs1027793; rs10823324; rs4075240; rs10823321; rs3740600; rs11812911; rs10998657; rs7073527; rs10762271; rs10762266; rs4746826; rs12359891; rs7091503; rs11813186; rs1472815; rs4746824; rs2279930; rs4746827; rs4072136; rs10128506; rs7101003; rs9663238; rs7092167; rs2394532; rs10082520; rs7085830; rs10762269; rs7900049; rs5030941; rs9645499; rs7903151; rs7083041; rs9645501; rs12246517; rs7068302; rs10998679; rs7091301; rs4746830; rs4746822; rs12573801; rs10823325; rs12257901; rs1021964; rs10762267; rs7091496; rs10128247; rs4746831; rs7918950; rs7089277; rs5030945; rs12573334; rs7082043; rs10762270; rs7069745; rs6480393; rs9665513; rs7919018; rs7091623; rs2394531; rs5030973; rs10998656; rs16926201; rs7918356; rs1983127; rs9645500; rs12253517; rs12778771; rs10732416; rs16926175; rs1106676; rs7091505; rs12261533; rs10762265; rs9663245; rs12221182; rs17566219; rs10998665; rs2279929; rs4745978; rs3740599; rs11814510; rs10998654; rs10998658; rs10823319; rs11814154; rs7907764; rs10823326; rs10823323; rs16926179; rs12253459; rs7899214; rs7097447; rs7896577; rs10998659; rs5030913; rs12241551; rs10082355; rs4746829; rs2394530; rs17566597; rs1911225; rs12358818; rs10466014; rs11817458; rs12781552; rs10998681; rs2063046; rs4745977; rs10823318; rs17566087; rs35542013; rs35746503; rs35008643; rs10998655; rs35305687; rs36205722; rs34566173; rs9703909; rs5785902; rs35934642; rs10998670; rs11446919; rs5785906; rs41314996; rs34401681; rs35310351; rs10998663; rs12355552; rs2002012; rs10998680; rs3998838; rs36067150; rs11813849; rs12358100; rs34861627; rs7917665; rs5785903; rs3740598; rs41279652; rs10998660; rs12768756; rs35672201; rs10998669; rs10998652; rs10998653; rs33937984; rs35796674; rs9645491; rs7914955; rs5785901; rs34028207; rs35748446; rs11294938; rs7923780; rs5030942; rs12268341; rs10619082; rs34970065; rs10998664; rs10556473; rs35255281; rs11816618; rs5030947; rs2894079; rs5785905; rs7910341; rs35523344; rs35696875; rs10524347; rs10604848; rs7095933; rs12217871; rs34634483; rs10647584; rs41279650; rs36003926; rs10998675; rs33955218; rs35614872; rs10998662; rs12768466; rs1967236; rs35199395; rs35420545; rs7917667; rs10128502; rs11348828; rs10998672; rs11341726; rs35691716; rs10998674; rs10998666; rs7092458; rs10646729; rs33969502; rs5030914; rs12358099; rs34746150; rs34668088; rs5785907; rs34529083; rs5785900; rs12248244; rs11340954; rs34459941; rs34306910; rs41304621; rs35015670; rs10647585; rs12780191; rs33974062; rs10998678; rs34801386; rs12360007; rs5785904; rs3086579; rs34225892; rs10650414; rs11373074; rs9665642; rs10998667; rs11599918; rs12765400; rs10998671; rs35204234; rs10740318; rs10762263; rs10762264; rs10998643; rs10998646; rs10998647; rs10998686; rs12241136; rs1472816; rs1472818; rs2394534; rs2394538; rs34516964; rs35372667; rs5030933; rs5030937; rs5030938; rs5030939; rs5030940

# Macromolecular_Interacting_Partner_11_General_References:
Not Available

# Macromolecular_Interacting_Partner_11_References:
Not Available

End of HMDB00169

Beginning of HMDB00172
# Accession_No:
HMDB00172

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-13 09:53:53

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
L-Isoleucine

# Description:
Branched chain amino acids (BCAA) are essential amino acids whose carbon structure is marked by a branch point. These three amino acids are critical to human life and are particularly involved in stress, energy and muscle metabolism. BCAA supplementation as therapy, both oral and intravenous, in human health and disease holds great promise. "BCAA" denotes valine, isoleucine and leucine which are branched chain essential amino acids. Despite their structural similarities, the branched amino acids have different metabolic routes, with valine going solely to carbohydrates, leucine solely to fats and isoleucine to both. The different metabolism accounts for different requirements for these essential amino acids in humans: 12 mg/kg, 14 mg/kg and 16 mg/kg of valine, leucine and isoleucine respectively. Furthermore, these amino acids have different deficiency symptoms. Valine deficiency is marked by neurological defects in the brain, while isoleucine deficiency is marked by muscle tremors. BCAA are decreased in patients with liver disease, such as hepatitis, hepatic coma, cirrhosis, extrahepatic biliary atresia or portacaval shunt; aromatic amino acids (AAA)-tyrosine, tryptophan and phenylalanine, as well as methionine-are increased in these conditions. Valine, in particular, has been established as a useful supplemental therapy to the ailing liver. All the BCAA probably compete with AAA for absorption into the brain. Supplemental BCAA with vitamin B6 and zinc help normalize the BCAA:AAA ratio. The BCAA are not without side effects. Leucine alone, for example, exacerbates pellagra and can cause psychosis in pellagra patients by increasing excretion of niacin in the urine. Leucine may lower brain serotonin and dopamine. A dose of 3 g of isoleucine added to the niacin regime has cleared leucine-aggravated psychosis in schizophrenic patients. Isoleucine may have potential as an antipsychotic treatment. Leucine is more highly concentrated in foods than other amino acids. A cup of milk contains 800 mg of leucine and only 500 mg of isoleucine and valine. A cup of wheat germ has about 1.6 g of leucine and 1 g of isoleucine and valine. The ratio evens out in eggs and cheese. One egg and an ounce of most cheeses each contain about 400 mg of leucine and 400 mg of valine and isoleucine. The ratio of leucine to other BCAA is greatest in pork, where leucine is 7 to 8 g and the other BCAA together are only 3 to 4 g. (http://www.dcnutrition.com)

# Synonyms:
(2S,3S)-2-Amino-3-methylpentanoate; (2S,3S)-2-Amino-3-methylpentanoic acid; (2S,3S)-2-amino-3-methyl-Pentanoate; (2S,3S)-2-amino-3-methyl-Pentanoic acid; (2S,3S)-a-Amino-b-methyl-n-valerate; (2S,3S)-a-Amino-b-methyl-n-valeric acid; (2S,3S)-a-Amino-b-methylvalerate; (2S,3S)-a-Amino-b-methylvaleric acid; (2S,3S)-alph-Amino-beta-methylvalerate; (2S,3S)-alph-Amino-beta-methylvaleric acid; (2S,3S)-alpha-Amino-beta-merthyl-n-valerate; (2S,3S)-alpha-Amino-beta-merthyl-n-valeric acid; (2S,3S)-alpha-Amino-beta-merthylvalerate; (2S,3S)-alpha-Amino-beta-merthylvaleric acid; (2S,3S)-alpha-Amino-beta-methyl-n-valerate; (2S,3S)-alpha-Amino-beta-methyl-n-valeric acid; (2S,3S)-alpha-Amino-beta-methylvalerate; (2S,3S)-alpha-Amino-beta-methylvaleric acid; (S)-Isoleucine; (S,S)-Isoleucine; 2-Amino-3-methylpentanoate; 2-Amino-3-methylpentanoic acid; 2-Amino-3-methylvalerate; 2-Amino-3-methylvaleric acid; 2S,3S-Isoleucine; Ile; Isoleucine; L-(+)-Isoleucine; L-Ile; [S-(R*,R*)]-2-Amino-3-methylpentanoate; [S-(R*,R*)]-2-Amino-3-methylpentanoic acid; erythro-L-Isoleucine; iso-leucine

# Chemical_IUPAC_Name:
2-amino-3-methyl-pentanoic acid

# Chemical_Formula:
C6H13NO2

# Chemical_Structure:
tbl_chemical:::HMDB00172_ZOOM.png:::119283232640494908

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00172_THUMB.png:::119283232481775440

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid; alpha-aminoacid

# Taxonomy_Biofunction:
Essential amino acids; Component of Aminoacyl-tRNA biosynthesis; Component of Valine, leucine and isoleucine biosynthesis

# Taxonomy_Source:
Exogenous

# Molecular_Weight:
131.09464

# Molecular_Weight_Avg:
131.17291

# Smiles_String_isomeric:
CC[C@H](C)[C@H](N)C(O)=O

# Smiles_String_canonical:
CCC(C)C(N)C(O)=O

# KEGG_Compound_ID:
C00407

# BioCyc_ID:
ILE

# PubChem_CID:
791

# PubChem_SID:
10367061; 10523014; 2814; 125479; 539740; 10367062; 546869; 7988809; 5097864; 8146837; 10367063; 197363; 10518101; 166007; 8150793; 152650

# OMIM_ID:
203750; 238340; 248600; 277100; 500005; 603324

# Metagene_ID:
0

# BiGG_ID:
34887

# Wikipedia_ID:
Ile

# METLIN_ID:
5193

# Ref_ID:
15911239; 12297216; 16611167; 14992292; 1981573; 11212317; 12603081; 8724342; 12414948; 12097436; 12393813; 6696735; 16365096; 12834252; 12444084; 2001478; 6198473

# ChEBI_ID:
17191

# CAS_Registry_Number:
73-32-5

# InChI:
InChI=1/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1

# Synthesis_Reference:
l-Isoleucine.     Marvel, C. S.    Organic Syntheses  (1941),  21  60-4.

# Melting_Point:
285.5 oC

# Melting_Point_predicted:
29.3 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
34.4 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]; 35 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
114.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-1.70 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-1.72 [Predicted by ALOGPS]; -1.6 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::L-Isoleucine.pdf:::1132562211104903558

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::L-Isoleucine.mol:::1132723811875264512

# SDF_File_[Text]:
tbl_chemical:::HMDB00172.sdf:::119283232163335947

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00172.pdb:::119283232345262163

# PDB_ID:
1H74

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::73-32-5-presat_JM.GIF:::1132883868109182029

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041027_P00_01_HW_1DP_presat.zip:::115204022975835406

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041027_P00_01_HW_1DP_Assigned.png:::115686807467530091

# C_NMR_Spectra:
tbl_cnmr:::041027_P00_01_HW_1DC_54.jpg:::115956269885025156

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041027_P00_01_HW_1DC_54.zip:::115956273799264020

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041027_P00_01_HW_1DC_54_Assigned.jpg:::115956280482793897

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041027_P00_01_HW_2DHSQC_169.jpg:::114496227907887782

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041027_P00_01_HW_2DHSQC_169.zip:::114496227908675696

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041027_P00_01_HW_2DHSQC_169_Assigned.jpg:::114546592608186992

# Predicted_H_NMR_Spectrum:
tbl_chemical:::L-Isoleucine.gif:::1132732117812261294

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00172_peaks.txt:::1156309594856161115

# Predicted_C_NMR_Spectrum:
tbl_chemical:::L-Isoleucine_C.gif:::1132737710834156757

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00172_peaks.txt:::1156310784364185938

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00172L.png:::117555262878590645; Medium Energy:tbl_ms:::HMDB00172M.png:::11755526814935937; High Energy:tbl_ms:::HMDB00172H.png:::117555271560035342

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000041.png:::116890824004638995

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000041.txt:::116890824004634863

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000041.png:::116890823975024446

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000041.txt:::116890824004670305

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Urine	1.579 (0.789-2.368)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Blood	40.0 +/- 20.0	umol/L	Newborn:0-30_days_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	69.0 +/- 13.0	umol/L	Children:1-13_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	64.0 +/- 13.0	umol/L	Children:1-13_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	84.0 +/- 18.0	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	64.0 +/- 13.0	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	44.0 +/- 6.0	umol/L	Children:1-13_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 93. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	81.0 +/- 18.0	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 93. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	56.0 +/- 12.0	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 93. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	62.0 (48.0-76.0)	umol/L	Adult:>18_yrs_old	Both	Normal	12297216
Cerebrospinal_Fluid(CSF)	21.0 +/- 16.0	uM	Adult:>18_yrs_old	Both	Normal	HMP Experimental
Cerebrospinal_Fluid(CSF)	3.9 +/- 1.0	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	8.4 +/- 2.6	umol/L	Adult:>18_yrs_old	N/A	Normal	15911239
Cerebrospinal_Fluid(CSF)	8.4 +/- 2.5	umol/L	Adult:>18_yrs_old	N/A	Normal	6198473
Cerebrospinal_Fluid(CSF)	4.3 +/- 3.4	umol/L	Adult:>18_yrs_old	N/A	Normal	6198473
Cerebrospinal_Fluid(CSF)	5.77 (3.30-8.24)	umol/L	Adult:>18_yrs_old	Both	Normal	12834252
Cerebrospinal_Fluid(CSF)	13.5 (8.8-18.2)	umol/L	Adult:>18_yrs_old	Both	Normal	12834252
Saliva	>10	umol/L	Adult:>18_yrs_old	Both	Normal	12097436


# Concentration_[Abnormal]:
Blood	40.3 (38.0-42.6)	umol/L	Adult:>18_yrs_old	Both	Acute seizures	14992292
Blood	42.7 (38.1-47.3)	umol/L	Adult:>18_yrs_old	Both	Refractory localization-related epilepsy (RLE)	14992292
Blood	130.0	umol/L	Adult:>18_yrs_old	Both	Diabetes	6696735
Cerebrospinal_Fluid(CSF)	7.1 +/- 4.2	umol/L	N/A	N/A	leukemia with CNS disease	15911239
Cerebrospinal_Fluid(CSF)	5.9 +/- 4.0	umol/L	N/A	N/A	leukemia	15911239


# Associated_Disorders:
2-hydroxyglutaric aciduria; Acrodermatitis Enteropathica; Acute seizures; Diabetes; End-stage Renal Disease (ESRD); leukemia; leukemia with CNS disease; Maple Syrup Urine Disease; Refractory Localization-Related Epilepsy (RLE); Spastic Diplegia

# Pathway_Names:
Valine, leucine and isoleucine biosynthesis;Valine, leucine and isoleucine degradation;Pantothenate and CoA biosynthesis;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
Valine,leucine,and_isoleucine_biosynthesis.jpg;valine,leucine,and_isoleucine_degradation.jpg;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00290;map00280;map00770;map00280;map00280

# Pathway_Graphs:
Valine,leucine,and_isoleucine_biosynthesis_Graph.jpg;valine,leucine,and_isoleucine_degradation_Graph.jpg;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
Valine,leucine,and_isoleucine_biosynthesis.xml;valine,leucine,and_isoleucine_degradation.xml;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5886

# Metabolic_Enzyme_1_Name:
Isoleucyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_1_Synonyms:
Isoleucine--tRNA ligase; IleRS; IRS

# Metabolic_Enzyme_1_Gene_Name:
IARS

# Metabolic_Enzyme_1_Protein_Sequence:
>IsoleucyltRNA synthetase, cytoplasmic
MSNKMLQQVPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHY
GHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEY
NNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGV
KVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAV
CVNPEMQYVKIKDVARGRLLILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFDYF
LKCKENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASG
CFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWF
VRVENMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFE
EVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGKGSLHRISEVFDCWFESGSMPYA
QVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLAS
DGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPW
YNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRL
YTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFL
TELMYQNLKVLIDPVSVQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIR
DRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGIRLRAEP
DHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDIRLMYTFDQATG
GTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAK
SEGTYLNSVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELEITLTRGSSLP
GPACAYVNLNICANGSEQGGVLLLENPKGDNRLDLLKLKSVVTSIFGVKNTELAVFHDET
EIQNQTDLLSLSGKTLCVTAGSAPSLINSSSTLLCQYINLQLLNAKPQECLMGTVGTLLL
ENPLGQNGLTHQGLLYEAAKVFGLRSRKLKLFLNETQTQEITEDIPVKTLNMKTVYVSVL
PTTADF

# Metabolic_Enzyme_1_Number_of_Residues:
1266

# Metabolic_Enzyme_1_Molecular_Weight:
144960

# Metabolic_Enzyme_1_Theoretical_pI:
6.10

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  isoleucine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  isoleucyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_1_Specific_Function:
ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)

# Metabolic_Enzyme_1_Pathway:
map00290  Valine, leucine and isoleucine biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_1_Reaction:
ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF08264:Anticodon_1;
PF00133:tRNA-synt_1

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 6.1.1.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
551622

# Metabolic_Enzyme_1_SwissProt_ID:
SYIC_HUMAN (P41252)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
IARS

# Metabolic_Enzyme_1_Geneatlas_id:
IARS

# Metabolic_Enzyme_1_hgnc_id:
HGNC:5330

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>3801 bp
ATGAGCAACAAAATGCTTCAACAAGTTCCAGAAAACATAAATTTTCCTGCTGAAGAAGAG
AAAATCTTGGAGTTTTGGACTGAATTTAATTGTTTTCAGGAATGCTTAAAGCAATCAAAA
CATAAACCAAAATTTACCTTCTATGATGGTCCTCCTTTTGCAACTGGACTGCCTCACTAT
GGACATATACTTGCGGGTACAATTAAAGATATAGTTACAAGATATGCTCACCAGAGTGGG
TTTCATGTTGACAGAAGATTTGGATGGGATTGCCATGGCTTACCTGTGGAATATGAAATT
GATAAGACACTGGGAATCAGAGGACCAGAGGATGTGGCCAAAATGGGGATTACAGAGTAT
AACAATCAGTGCCGAGCAATTGTGATGAGATATTCTGCTGAGTGGAAGTCTACTGTTAGC
AGACTTGGCCGATGGATTGACTTTGACAATGACTATAAAACTCTGTATCCACAATTCATG
GAATCAGTCTGGTGGGTCTTCAAACAACTCTATGATAAAGGCCTTGTTTATAGAGGTGTG
AAAGTCATGCCCTTCTCTACGGCATGTAACACTCCACTTTCCAACTTCGAGTCACACCAG
AATTATAAGGATGTTCAAGATCCTTCAGTATTTGTAACTTTCCCTTTGGAAGAAGATGAA
ACTGTATCTTTAGTTGCTTGGACAACCACTCCCTGGACTCTACCTAGTAACCTTGCTGTG
TGTGTTAATCCAGAAATGCAATATGTGAAAATTAAAGATGTTGCCAGAGGACGATTACTC
ATTTTAATGGAAGCCAGATTGTCAGCCCTCTATAAATTGGAGAGTGACTATGAGATCCTT
GAAAGATTTCCTGGTGCCTATCTTAAAGGCAAGAAGTACAGGCCCCTGTTTGACTATTTC
CTGAAGTGTAAAGAGAATGGCGCTTTCACTGTGCTTGTTGACAACTATGTGAAGGAAGAA
GAAGGCACAGGGGTTGTCCACCAAGCTCCTTACTTCGGTGCTGAGGACTATCGGGTCTGT
ATGGACTTTAACATTATTCGGAAAGACTCACTCCCTGTTTGCCCTGTGGATGCTTCAGGC
TGCTTCACAACGGAGGTGACAGATTTCGCAGGACAGTATGTGAAGGATGCTGACAAAAGT
ATCATCAGGACTTTGAAGGAACAAGGCCGACTTCTGGTTGCCACCACCTTCACTCACAGC
TACCCTTTTTGCTGGAGATCAGACACTCCTCTAATTTACAAAGCAGTGCCCAGCTGGTTT
GTGCGAGTGGAGAACATGGTGGACCAGCTCCTAAGGAACAATGACCTGTGCTACTGGGTC
CCAGAGTTGGTACGAGAAAAACGATTTGGAAATTGGCTGAAAGATGCACGTGACTGGACA
ATTTCCAGAAACAGATACTGGGGCACCCCCATCCCACTGTGGGTCAGCGATGACTTTGAG
GAGGTGGTATGCATTGGGTCAGTGGCGGAACTTGAAGAACTGTCAGGAGCAAAGATCTCA
GATCTCCACAGAGAGAGTGTTGACCACCTGACCATTCCTTCACGCTGTGGGAAGGGATCC
TTGCACCGCATCTCTGAAGTGTTTGACTGTTGGTTTGAGAGTGGCAGCATGCCCTATGCT
CAGGTTCATTACCCGTTTGAAAACAAGAGGGAGTTTGAGGATGCTTTTCCTGCAGATTTC
ATTGCCGAGGGCATCGACCAAACCAGAGGATGGTTTTATACCCTGCTGGTGCTGGCCACG
GCCCTCTTTGGACAACCGCCTTTCAAGAACGTAATTGTGAATGGGCTTGTCCTGGCAAGT
GATGGCCAAAAAATGAGCAAACGGAAAAAGAATTATCCAGATCCAGTTTCCATCATCCAG
AAGTATGGTGCTGATGCCCTCAGATTATATCTGATTAACTCCCCTGTGGTGAGAGCAGAA
AACCTCCGCTTTAAAGAAGAGGGTGTGCGGGACGTCCTTAAGGATGTACTGCTCCCATGG
TACAATGCCTATCGCTTCTTAATCCAGAACGTTCTGAGGCTCCAGAAGGAGGAAGAAATA
GAATTTCTCTACAATGAGAACACGGTTAGAGAAAGCCCCAACATTACAGACCGGTGGATC
CTGTCCTTCATGCAGTCTCTCATTGGCTTCTTTGAGACTGAAATGGCAGCTTATAGGCTT
TATACTGTGGTGCCTCGCCTGGTCAAGTTTGTAGATATTCTGACCAATTGGTATGTTAGA
ATGAACCGCAGAAGATTAAAGGGTGAAAATGGGATGGAGGATTGTGTCATGGCCCTAGAA
ACCTTGTTTAGTGTTCTGCTTTCTCTTTGCAGACTTATGGCTCCCTACACACCTTTTCTC
ACTGAATTGATGTACCAGAATCTAAAGGTGCTGATTGACCCTGTTTCTGTTCAGGACAAG
GACACACTCAGCATTCACTACCTCATGCTGCCCCGTGTTCGAGAAGAATTGATTGACAAG
AAAACAGAGAGTGCAGTATCTCAGATGCAGTCTGTGATTGAACTTGGAAGAGTGATCAGA
GACCGAAAAACTATTCCCATAAAGTATCCTTTGAAAGAAATTGTGGTTATCCATCAAGAT
CCAGAAGCTCTTAAAGATATCAAGTCTTTGGAGAAGTATATCATTGAGGAACTCAATGTT
CGAAAAGTTACACTGTCTACAGATAAAAACAAGTATGGCATTCGGCTAAGGGCAGAACCA
GATCACATGGTCCTGGGGAAGCGTCTGAAGGGAGCCTTTAAGGCAGTGATGACGTCCATC
AAGCAGTTGAGCAGTGAGGAGCTGGAGCAGTTCCAGAAGACTGGGACCATTGTTGTGGAA
GGCCATGAATTGCACGATGAAGACATCCGCCTCATGTACACCTTTGATCAGGCCACAGGT
GGGACTGCGCAATTTGAAGCACACTCAGATGCTCAGGCTTTGGTCCTCTTAGATGTCACT
CCTGACCAGTCAATGGTAGATGAAGGAATGGCTCGGGAAGTCATCAATCGCATACAGAAA
CTTCGCAAAAAGTGCAATCTGGTTCCAACTGATGAAATCACAGTGTACTATAAAGCAAAG
TCTGAAGGAACATATCTGAATAGTGTTATTGAAAGCCACACAGAGTTCATATTTACCACC
ATAAAGGCTCCCTTGAAACCATATCCAGTTTCTCCATCGGATAAAGTCCTTATTCAAGAA
AAAACACAGTTGAAGGGATCTGAACTGGAAATTACACTCACCAGAGGATCTTCCCTTCCT
GGTCCTGCTTGTGCATATGTCAATCTTAACATTTGTGCAAATGGCAGTGAACAAGGTGGA
GTATTGCTCCTGGAAAATCCAAAAGGTGACAATAGGTTGGACCTTTTAAAGCTGAAGAGT
GTTGTCACTAGCATTTTTGGTGTGAAAAATACAGAGCTGGCTGTCTTCCATGATGAAACA
GAAATACAAAACCAAACTGACTTACTGAGTCTTAGTGGAAAAACACTTTGTGTGACTGCA
GGATCGGCTCCCTCTCTGATCAACAGTTCTAGTACTCTTCTTTGTCAGTATATCAACCTA
CAGCTCCTGAATGCAAAGCCACAAGAGTGTTTAATGGGGACAGTGGGCACTCTCCTGCTT
GAAAACCCACTTGGGCAGAATGGACTCACCCACCAAGGTCTTCTGTATGAAGCAGCCAAG
GTGTTTGGCCTTCGGAGCAGGAAGCTAAAGCTGTTTCTGAATGAGACCCAAACGCAGGAA
ATTACAGAAGACATCCCCGTGAAGACTTTGAATATGAAGACTGTGTATGTTTCTGTGTTA
CCAACAACAGCAGACTTCTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
D28473

# Metabolic_Enzyme_1_Chromosome_Location:
Not Available

# Metabolic_Enzyme_1_Locus:
Not Available

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
8052601; 7721108

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5536

# Metabolic_Enzyme_2_Name:
Branched-chain-amino-acid aminotransferase, cytosolic

# Metabolic_Enzyme_2_Synonyms:
BCAT(c; ECA39 protein

# Metabolic_Enzyme_2_Gene_Name:
BCAT1

# Metabolic_Enzyme_2_Protein_Sequence:
>Branchedchainaminoacid aminotransferase, cytosolic
MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTV
EWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRM
YRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPTK
ALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEAVDN
GCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQ
WGEFKVSERYLTMDDLSTALEGNRVREMFGSGTACVVCPVSDILYKGETIHIPTMENGPK
LASRILSKLTDIQYGREESDWTIVLS

# Metabolic_Enzyme_2_Number_of_Residues:
386

# Metabolic_Enzyme_2_Molecular_Weight:
42953

# Metabolic_Enzyme_2_Theoretical_pI:
4.95

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
Function:  branched-chain-amino-acid transaminase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  branched chain family amino acid metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine

# Metabolic_Enzyme_2_Pathway:
map00280  Valine, leucine and isoleucine degradation;
 map00290  Valine, leucine and isoleucine biosynthesis;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_2_Reaction:
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01063:Aminotran_4

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.6.1.42

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1036780

# Metabolic_Enzyme_2_SwissProt_ID:
BCAT1_HUMAN (P54687)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
BCAT1

# Metabolic_Enzyme_2_Geneatlas_id:
BCAT1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:976

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1155 bp
ATGGATTGCAGTAACGGATCGGCAGAGTGTACCGGAGAAGGAGGATCAAAAGAGGTGGTG
GGGACTTTTAAGGCTAAAGACCTAATAGTCACACCAGCTACCATTTTAAAGGAAAAACCA
GACCCCAATAATCTGGTTTTTGGAACTGTGTTCACGGATCATATGCTGACGGTGGAGTGG
TCCTCAGAGTTTGGATGGGAGAAACCTCATATCAAGCCTCTTCAGAACCTGTCATTGCAC
CCTGGCTCATCAGCTTTGCACTATGCAGTGGAATTATTTGAAGGATTGAAGGCATTTCGA
GGAGTAGATAATAAAATTCGACTGTTTCAGCCAAACCTCAACATGGATAGAATGTATCGC
TCTGCTGTGAGGGCAACTCTGCCGGTATTTGACAAAGAAGAGCTCTTAGAGTGTATTCAA
CAGCTTGTGAAATTGGATCAAGAATGGGTCCCATATTCAACATCTGCTAGTCTGTATATT
CGTCCTGCATTCATTGGAACTGAGCCTTCTCTTGGAGTCAAGAAGCCTACCAAAGCCCTG
CTCTTTGTACTCTTGAGCCCAGTGGGACCTTATTTTTCAAGTGGAACCTTTAATCCAGTG
TCCCTGTGGGCCAATCCCAAGTATGTAAGAGCCTGGAAAGGTGGAACTGGGGACTGCAAG
ATGGGAGGGAATTACGGCTCATCTCTTTTTGCCCAATGTGAAGACGTAGATAATGGGTGT
CAGCAGGTCCTGTGGCTCTATGGCAGAGACCATCAGATCACTGAAGTGGGAACTATGAAT
CTTTTTCTTTACTGGATAAATGAAGATGGAGAAGAAGAACTGGCAACTCCTCCACTAGAT
GGCATCATTCTTCCAGGAGTGACAAGGCGGTGCATTCTGGACCTGGCACATCAGTGGGGT
GAATTTAAGGTGTCAGAGAGATACCTCACCATGGATGACTTGACAACAGCCCTGGAGGGG
AACAGAGTGAGAGAGATGTTTAGCTCTGGTACAGCCTGTGTTGTTTGCCCAGTTTCTGAT
ATACTGTACAAAGGCGAGACAATACACATTCCAACTATGGAGAATGGTCCTAAGCTGGCA
AGCCGCATCTTGAGCAAATTAACTGATATCCAGTATGGAAGAGAAGAGAGCGACTGGACA
ATTGTGCTATCCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
U21551

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_2_Locus:
12pter-q12

# Metabolic_Enzyme_2_SNPs:
rs7313020; rs17374285; rs1872644; rs2220269; rs1872645; rs6487421; rs2353483; rs4453321; rs6487420; rs1054277; rs2353481; rs1471842; rs1043851; rs3198082; rs1054281; rs1054279; rs1043881; rs12371993; rs4963801; rs7296995; rs7305794; rs2029986; rs11486; rs2200509; rs12578267; rs6487419; rs2353482; rs2046524; rs3825167; rs11047652; rs7134734; rs11047654; rs12231434; rs10842409; rs11047724; rs17371571; rs7134619; rs7306168; rs7315828; rs7134871; rs1872646; rs2046525; rs1471844; rs976436; rs2291894; rs2173606; rs2062497; rs2242400; rs7954529; rs3759085; rs1813470; rs7310300; rs11613673; rs7297229; rs4963596; rs11047676; rs6487428; rs10842418; rs10842431; rs937503; rs7296211; rs2029985; rs4963820; rs2046526; rs6487431; rs7296881; rs10771144; rs11610069; rs2352745; rs12425320; rs6487436; rs11047684; rs954200; rs3736212; rs2242399; rs7976928; rs7977807; rs4462438; rs6487435; rs7299023; rs7964239; rs12319639; rs954199; rs10466757; rs12424348; rs7968890; rs10505954; rs2133587; rs11047717; rs718567; rs11047686; rs7975904; rs3759086; rs10842413; rs6487434; rs11047679; rs4963822; rs7312749; rs6487429; rs2352746; rs16928083; rs10842414; rs7969149; rs3950612; rs10505952; rs10771142; rs6487437; rs16928141; rs12422599; rs2129236; rs1566406; rs12580682; rs10771138; rs4963810; rs2133588; rs16928207; rs16928163; rs16928145; rs12423866; rs4531567; rs16928217; rs6487433; rs11047685; rs2133582; rs11047716; rs10842429; rs7305924; rs7967945; rs1499805; rs11047709; rs7956863; rs7299760; rs11047692; rs12424211; rs7962203; rs954201; rs4963830; rs11609552; rs2047554; rs10771132; rs10842415; rs11047707; rs7959036; rs2353478; rs10505955; rs11047689; rs1546197; rs10842423; rs4143211; rs16928097; rs11047696; rs4963814; rs11047682; rs7978032; rs10771133; rs11608526; rs12318469; rs4963818; rs10160847; rs12366540; rs16928111; rs1119693; rs1566407; rs2353472; rs10842420; rs6487430; rs10842424; rs17314214; rs1392196; rs4143210; rs924191; rs11047708; rs1546196; rs12320158; rs1497257; rs4963594; rs10743524; rs10842416; rs3736211; rs12579934; rs12321766; rs10771140; rs10842427; rs10842433; rs7960010; rs10128933; rs7313260; rs16928089; rs7972930; rs7298696; rs1391028; rs12302883; rs10771139; rs10771130; rs9804952; rs7303413; rs4963804; rs10842421; rs7978793; rs12227915; rs7973974; rs10842417; rs2047555; rs7970244; rs10505953; rs4963808; rs1392195; rs10771128; rs7138654; rs2201712; rs10771141; rs10771127; rs11047674; rs7961778; rs2306766; rs11835201; rs3759088; rs16928168; rs11047693; rs7965655; rs4522264; rs10842422; rs11047665; rs10161442; rs16928173; rs7966104; rs12321731; rs4963805; rs10771146; rs3926539; rs11047712; rs2062495; rs4603392; rs11047711; rs11047721; rs2883181; rs1471843; rs12427117; rs10743526; rs12296255; rs11615930; rs12422783; rs11047697; rs11047706; rs4963802; rs1105937; rs11833854; rs10771129; rs4963823; rs17313239; rs10771143; rs10771134; rs10466799; rs7136436; rs10743521; rs7969444; rs17315488; rs12579655; rs12172778; rs7138685; rs3759087; rs4406910; rs1875092; rs11047677; rs2133589; rs7967953; rs7955672; rs7398085; rs7484721; rs10047592; rs12318827; rs11615863; rs4963806; rs4963821; rs12322309; rs11830394; rs7976171; rs16928186; rs11047714; rs11047668; rs4459405; rs7966783; rs10743525; rs12229422; rs6487427; rs12817139; rs1075061; rs4246225; rs7953453; rs12230816; rs12322341; rs7969612; rs12320547; rs12818299; rs11047700; rs11047715; rs7138806; rs1077102; rs17342494; rs2353479; rs17372766; rs7961688; rs4963817; rs11047723; rs12372519; rs17373566; rs5012437; rs12423288; rs16928169; rs11047669; rs7955886; rs11047695; rs17375619; rs17316319; rs1075062; rs12427184; rs7299787; rs11830163; rs12371441; rs11610213; rs2291895; rs11047678; rs11047681; rs9989035; rs11047691; rs11047671; rs11047667; rs11047699; rs12319283; rs12228257; rs4031159; rs12230878; rs11613710; rs11613482; rs4963815; rs7298907; rs7307610; rs11047702; rs2353473; rs10047590; rs10771145; rs12316589; rs17315467; rs1846581; rs1119692; rs2352747; rs10842434; rs11047660; rs7961152; rs11047657; rs10743527; rs7969649; rs1875091; rs4963593; rs7978338; rs4143212; rs4963811; rs16928171; rs11612450; rs12313518; rs2220270; rs2173605; rs11047722; rs4296116; rs10842430; rs16928149; rs7970200; rs12296315; rs10219671; rs2255206; rs2353484; rs2353485; rs3794263; rs7959326; rs10842436; rs1048368; rs2353486; rs10734736; rs7970725; rs1463625; rs1497255; rs7955676; rs1057204; rs35600421; rs17374606; rs4423275; rs35585041; rs11047651; rs35186964; rs12582215; rs15643; rs12366411; rs11433688; rs35804569; rs34453620; rs36085546; rs33947278; rs5797102; rs11047650; rs11384696; rs12301168; rs666928; rs12831930; rs35951011; rs36070747; rs12828108; rs10688526; rs12296452; rs34174229; rs34780357; rs4963819; rs34032061; rs34504461; rs34414606; rs5797104; rs34876959; rs5797105; rs34153775; rs12316475; rs7967922; rs665254; rs34501736; rs12817209; rs35203857; rs12422829; rs12296646; rs866358; rs12301149; rs11047661; rs35989805; rs12820872; rs34044660; rs35455721; rs34556925; rs1874598; rs7485585; rs10585254; rs35693234; rs35550560; rs11370314; rs12228347; rs5797108; rs11047687; rs11415752; rs10466800; rs11047659; rs35850216; rs17314570; rs625604; rs2270771; rs11047683; rs34237642; rs9804807; rs4963809; rs12817395; rs10585144; rs12310054; rs34835991; rs11616042; rs12300357; rs35406045; rs12319312; rs12229613; rs2649778; rs2133584; rs2291896; rs34227038; rs10842432; rs10595838; rs36124065; rs35488171; rs35203074; rs35427447; rs35151527; rs11608755; rs2133585; rs12823840; rs4031157; rs3950611; rs11615196; rs12818315; rs3044337; rs34802588; rs12816139; rs12816228; rs34677835; rs34476055; rs35060237; rs34165520; rs34902696; rs35984920; rs34151647; rs34717106; rs12310217; rs12818883; rs35033368; rs4963595; rs5797106; rs11047719; rs34329602; rs2645897; rs11310819; rs35929602; rs34808872; rs34508149; rs11047670; rs12825177; rs12827517; rs7968043; rs7980970; rs1693356; rs12810541; rs35423225; rs33963375; rs4432099; rs11047655; rs35331816; rs11047710; rs2645908; rs2649777; rs7309420; rs860869; rs10553165; rs28459289; rs12312774; rs11047666; rs35669075; rs12424534; rs11616041; rs35606332; rs17315509; rs12810226; rs11612132; rs35593379; rs2062496; rs10743522; rs11614032; rs7306822; rs35643898; rs11047703; rs35195819; rs2270772; rs2133583; rs11047720; rs35270432; rs34776365; rs11394415; rs28678340; rs10541735; rs35646001; rs840797; rs4963825; rs10643112; rs4963824; rs7970415; rs11047718; rs11047656; rs4963826; rs11327300; rs34707102; rs2133586; rs2883180; rs34370749; rs11440596; rs34430745; rs11392086; rs11047701; rs12319952; rs34143445; rs5797107; rs11047672; rs11047688; rs7296005; rs34780543; rs12227952; rs34331143; rs10561433; rs11318750; rs12230723; rs11047680; rs2645904; rs11345548; rs35939998; rs11614469; rs675368; rs4963807; rs596765; rs35566363; rs11442641; rs34858948; rs12320957; rs34377944; rs12313801; rs35181244; rs4963812; rs10616253; rs36137247; rs7972955; rs2220271; rs11047662; rs35801229; rs11047694; rs10697494; rs12817355; rs2645907; rs12581783; rs4031158; rs35477401; rs4031153; rs667888; rs1622629; rs4963813; rs2649776; rs34705263; rs35978550; rs11047704; rs34761531; rs7975240; rs3044287; rs12818310; rs12818301; rs7308285; rs7953787; rs10546505; rs36067986; rs35477889; rs7136511; rs34706565; rs34990218; rs16928147; rs34860589; rs12229575; rs36036274; rs11047705; rs35440053; rs11320109; rs866357; rs34549035; rs11047673; rs11047663; rs4400889; rs7131753; rs12367115; rs28491628; rs11047713; rs10548732; rs12830129; rs1075063; rs12582334; rs7968607; rs9668094; rs35277052; rs12821845; rs12299696; rs3830305; rs12371444; rs12831941; rs10589289; rs11369972; rs34420618; rs11047690; rs11831592; rs4257068; rs35063724; rs11047664; rs587649; rs10743523; rs10714031; rs11047698; rs668707; rs36035411; rs34285635; rs1497256; rs593165; rs9668028; rs35543389; rs10662028; rs5797103; rs35693867; rs3044290; rs9988971; rs34676819; rs10842435; rs35336188; rs1872643; rs10219508; rs10219610; rs1032589; rs10743520; rs10771123; rs10771124; rs10771125; rs10842408; rs10842437; rs10842439; rs11047645; rs11047647; rs11047648; rs11047726; rs11829886; rs1213075; rs12301529; rs12368831; rs12582944; rs12819423; rs1471841; rs16928015; rs17316445; rs17322922; rs17322957; rs34277634; rs34589683; rs35085353; rs4255624; rs4406909; rs4429151; rs4569089; rs4963795; rs4963796; rs4963797; rs4963800; rs619755; rs6487417; rs7299477; rs7307399; rs7961311; rs7961506; rs7964847; rs7979563; rs7979723

# Metabolic_Enzyme_2_General_References:
8692959

# Metabolic_Enzyme_2_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8503

# Macromolecular_Interacting_Partner_1_Name:
Large neutral amino acids transporter small subunit 3

# Macromolecular_Interacting_Partner_1_Synonyms:
L-type amino acid transporter 3; Solute carrier family 43 member 1; Prostate cancer overexpressed gene 1 protein

# Macromolecular_Interacting_Partner_1_Gene_Name:
SLC43A1

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Large neutral amino acids transporter small subunit 3
MAPTLQQAYRRRWWMACTAVLENLFFSAVLLGWGSLLIILKNEGFYSSTCPAESSTNTTQ
DEQRRWPGCDQQDEMLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTL
MALASRDVEALSPLIFLALSLNGFGGICLTFTSLTLPNMFGNLRSTLMALMIGSYASSAI
TFPGIKLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWPIEAFPAPEEVNYTKKIKLSGLA
LDHKVTGDLFYTHVTTMGQRLSQKAPSLEDGSDAFMSPQDVRGTSENLPERSVPLRKSLC
SPTFLWSLLTMGMTQLRIIFYMAAVNKMLEYLVTGGQEHETNEQQQKVAETVGFYSSVFG
AMQLLCLLTCPLIGYIMDWRIKDCVDAPTQGTVLGDARDGVATKSIRPRYCKIQKLTNAI
SAFTLTNLLLVGFGITCLINNLHLQFVTFVLHTIVRGFFHSACGSLYAAVFPSNHFGTLT
GLQSLISAVFALLQQPLFMAMVGPLKGEPFWVNLGLLLFSLLGFLLPSYLFYYRARLQQE
YAANGMGPLKVLSGSEVTA

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
559

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
61478

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.73

# Macromolecular_Interacting_Partner_1_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Signals:
1-32

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
20-40
78-98
105-124
131-151
168-188
191-211
304-324
357-377
419-439
446-466
485-505
510-530

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
3462515

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
LAT3_HUMAN (O75387)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
SLC43A1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
SLC43A1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9225

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; multi-pass membrane protein (Probable)

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1680 bp
ATGGCCCCCACGCTGCAACAGGCGTACCGGAGGCGCTGGTGGATGGCCTGCACGGCTGTG
CTGGAGAACCTCTTCTTCTCTGCTGTACTCCTGGGCTGGGGCTCCCTGTTGATCATTCTG
AAGAACGAGGGCTTCTATTCCAGCACGTGCCCAGCTGAGAGCAGCACCAACACCACCCAG
GATGAGCAGCGCAGGTGGCCAGGCTGTGACCAGCAGGACGAGATGCTCAACCTGGGCTTC
ACCATTGGTTCCTTCGTGCTCAGCGCCACCACCCTGCCACTGGGGATCCTCATGGACCGC
TTTGGCCCCCGACCCGTGCGGCTGGTTGGCAGTGCCTGCTTCACTGCGTCCTGCACCCTC
ATGGCCCTGGCCTCCCGGGACGTGGAAGCTCTGTCTCCGTTGATATTCCTGGCGCTGTCC
CTGAATGGCTTTGGTGGCATCTGCCTAACGTTCACTTCACTCACGCTGCCCAACATGTTT
GGGAACCTGCGCTCCACGTTAATGGCCCTCATGATTGGCTCTTACGCCTCTTCTGCCATT
ACGTTCCCAGGAATCAAGCTGATCTACGATGCCGGTGTGGCCTTCGTGGTCATCATGTTC
ACCTGGTCTGGCCTGGCCTGCCTTATCTTTCTGAACTGCACCCTCAACTGGCCCATCGAA
GCCTTTCCTGCCCCTGAGGAAGTCAATTACACGAAGAAGATCAAGCTGAGTGGGCTGGCC
CTGGACCACAAGGTGACAGGTGACCTCTTCTACACCCATGTGACCACCATGGGCCAGAGG
CTCAGCCAGAAGGCCCCCAGCCTGGAGGACGGTTCGGATGCCTTCATGTCACCCCAGGAT
GTTCGGGGCACCTCAGAAAACCTTCCTGAGAGGTCTGTCCCCTTACGCAAGAGCCTCTGC
TCCCCCACTTTCCTGTGGAGCCTCCTCACCATGGGCATGACCCAGCTGCGGATCATCTTC
TACATGGCTGCTGTGAACAAGATGCTGGAGTACCTTGTGACTGGTGGCCAGGAGCATGAG
ACAAATGAACAGCAACAAAAGGTGGCAGAGACAGTTGGGTTCTACTCCTCCGTCTTCGGG
GCCATGCAGCTGTTGTGCCTTCTCACCTGCCCCCTCATTGGCTACATCATGGACTGGCGG
ATCAAGGACTGCGTGGACGCCCCAACTCAGGGCACTGTCCTCGGAGATGCCAGGGACGGG
GTTGCTACCAAATCCATCAGACCACGCTACTGCAAGATCCAAAAGCTCACCAATGCCATC
AGTGCCTTCACCCTGACCAACCTGCTGCTTGTGGGTTTTGGCATCACCTGTCTCATCAAC
AACTTACACCTCCAGTTTGTGACCTTTGTCCTGCACACCATTGTTCGAGGTTTCTTCCAC
TCAGCCTGTGGGAGTCTCTATGCTGCAGTGTTCCCATCCAACCACTTTGGGACGCTGACA
GGCCTGCAGTCCCTCATCAGTGCTGTGTTCGCCTTGCTTCAGCAGCCACTTTTCATGGCG
ATGGTGGGACCCCTGAAAGGAGAGCCCTTCTGGGTGAATCTGGGCCTCCTGCTATTCTCA
CTCCTGGGATTCCTGTTGCCTTCCTACCTCTTCTATTACCGTGCCCGGCTCCAGCAGGAG
TACGCCGCCAATGGGATGGGCCCACTGAAGGTGCTTAGCGGCTCTGAGGTGACCGCATAG


# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AF045584

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11p11.2-p11.1

# Macromolecular_Interacting_Partner_1_SNPs:
rs34746107; rs2649666; rs2848634; rs2581930; rs2581922; rs3851118; rs7934626; rs10160419; rs4939146; rs2250673; rs2649667; rs2729385; rs1001956; rs2729387; rs2848635; rs2848640; rs2584856; rs6591429; rs7933797; rs7930636; rs2511984; rs2729383; rs12275916; rs4939147; rs2848641; rs10750864; rs2454664; rs2729384; rs2848626; rs10160797; rs7939745; rs17151933; rs35730224; rs12277281; rs3758921; rs2439449; rs12802139; rs34744429; rs10160791; rs35278250; rs12787387; rs35597234; rs7119008; rs35651755; rs11229044; rs35873904; rs9667827; rs11460423; rs12280370; rs7130939; rs12280374; rs5792045; rs7479313; rs34199356; rs5792044; rs12224126; rs34498267; rs28611152; rs2511995; rs11229045; rs34655291; rs2017749; rs2467327; rs12799911; rs3971879; rs548788; rs505057; rs12802178; rs12799919; rs11229042; rs28582317; rs12802150; rs11402481; rs34394294; rs10623104; rs12802141; rs36028746; rs12274357; rs5792047; rs34256751; rs34082151; rs4565916; rs34961925; rs36069501; rs12797003; rs5792048; rs12802027; rs11402480; rs12796287; rs11229043; rs12296041; rs2509899; rs28799317; rs12800096; rs35726939; rs533719; rs35690697; rs5792046; rs9667020; rs3051419; rs28655441; rs2439889; rs12785401; rs2439890; rs35222358; rs9666076; rs34549010; rs12293474; rs11229047; rs12576832; rs34213260; rs11229050; rs12418994; rs2258835; rs2729353; rs2729377; rs2955849; rs2955850; rs4938869; rs4939148

# Macromolecular_Interacting_Partner_1_General_References:
9722952; 12930836; 9255310; 11956097

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8639

# Macromolecular_Interacting_Partner_2_Name:
L-type amino acid transporter 4

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
SLC43A2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Ltype amino acid transporter 4
MAPTLATAHRRRWWMACTAVLENLLFSAVLLGWGSLLIMLKSEGFYSYLCTEPENVTNGT
VGGTAEPGHEEVSWMNGWLSCQAQDEMLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRL
LGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMCMTFTSLTLPNMFGDLRSTFI
ALMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCSGLVFLNCFFNWPLEPFPGPEDM
DYSVKIKFSWLGFDHKITGKQFYKQVTTVGRRLSVGSSMRSAKEQVALQEGHKLCLSTVD
LEVKCQPDAAVAPSFMHSVFSPILLLSLVTMCVTQLRLIFYMGAMNNILKFLVSGDQKTV
MATVGLYTSIFGVLQLLCLLTAPVIGYIMDWRLKECEDASEEPEEKDANQGEKKKKKRDR
QIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTIVRGFIHSAVGGLYAAVY
PSTQFGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLI
CYRRQLERQLQQRQEDDKLFLKINGSSNQEAFV

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
573

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
63150

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
8.00

# Macromolecular_Interacting_Partner_2_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF07690:MFS_1

# Macromolecular_Interacting_Partner_2_Signals:
1-32

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
20-39; 87-109; 118-135; 145-167; 179-201; 205-227; 323-345; 360-382; 426-448; 458-480; 487-509; 519-541

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
61287131

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
Q5CD75_HUMAN (Q5CD75)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
SLC43A2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
SLC43A2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:23087

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1722 bp
ATGGCGCCCACCCTGGCCACTGCCCATCGGCGCCGCTGGTGGATGGCCTGCACGGCCGTG
CTGGAGAACCTCCTCTTCTCGGCAGTCCTCCTGGGCTGGGGCTCGCTGCTCATCATGCTC
AAGTCAGAGGGCTTTTACTCCTACCTGTGTACCGAGCCAGAGAATGTCACCAATGGCACA
GTGGGCGGCACAGCAGAGCCGGGGCACGAGGAGGTGAGCTGGATGAACGGCTGGCTCAGC
TGCCAGGCCCAGGACGAGATGCTAAATTTGGCCTTCACTGTGGGCTCCTTTCTGCTCAGT
GCCATCACCCTGCCCCTGGGTATCGTCATGGACAAGTATGGCCCGAGGAAGCTCAGGCTG
CTGGGCAGCGCCTGCTTCGCGGTTTCCTGCTTGCTGATTGCGTACGGAGCAAGTAAACCA
AACGCTCTCTCCGTGCTCATCTTCATCGCCCTGGCTCTGAATGGCTTTGGTGGGATGTGT
ATGACCTTCACCTCATTAACACTGCCCAACATGTTCGGCGACCTTCGGTCCACGTTTATT
GCCTTGATGATTGGGTCCTACGCCTCCTCGGCAGTCACCTTTCCAGGAATCAAGCTCATC
TATGATGCTGGTGTCTCCTTCATCGTCGTCCTCGTGGTCTGGGCCGGCTGCTCCGGGCTG
GTTTTCCTCAACTGCTTCTTTAACTGGCCCCTTGAGCCCTTCCCGGGGCCGGAGGACATG
GACTACTCGGTGAAGATCAAGTTCAGCTGGCTGGGCTTTGACCACAAGATCACAGGGAAG
CAGTTCTACAAGCAGGTGACCACGGTGGGCCGGCGCCTGAGTGTGGGCAGCTCCATGAGG
AGTGCCAAGGAGCAGGTGGCGCTGCAGGAGGGCCACAAGCTGTGCCTGTCCACCGTCGAC
CTGGAGGTGAAGTGCCAGCCGGATGCCGCAGTGGCCCCCTCCTTCATGCACAGCGTGTTC
AGCCCCATCCTGCTGCTCAGCCTGGTCACCATGTGCGTCACGCAGCTGCGGCTCATCTTC
TACATGGGGGCTATGAACAACATCCTCAAGTTCCTGGTCAGCGGCGACCAGAAGACAGTG
ATGGCCACGGTTGGCCTCTACACCTCCATCTTCGGCGTGCTCCAGCTGCTGTGCCTGCTG
ACGGCCCCCGTCATTGGCTACATCATGGACTGGAGGCTGAAGGAGTGTGAAGACGCCTCC
GAGGAGCCCGAGGAGAAAGACGCCAACCAAGGCGAGAAGAAAAAGAAGAAGCGGGACCGG
CAGATCCAGAAGATCACTAATGCCATGCGGGCCTTCGCCTTCACCAACCTGCTGCTCGTG
GGCTTTGGGGTGACCTGCCTCATTCCCAACCTGCCTCTCCAGATCCTCTCCTTCATCCTG
CACACAATCGTGCGAGGATTCATCCACTCCGCTGTCGGGGGCCTGTACGCTGCCGTGTAC
CCCTCCACCCAGTTCGGCAGCCTCACGGGACTGCAGTCTCTGATCAGCGCGCTCTTCGCC
CTTCTGCAGCAGCCGCTGTTTCTGGCCATGATGGGTCCTCTCCAGGGAGACCCTCTGTGG
GTGAACGTGGGGCTGCTCCTTCTCAGCCTGCTGGGCTTCTGCCTCCCGCTCTACCTGATC
TGCTACCGGCGCCAGCTGGAGCGGCAGCTGCAGCAGAGGCAGGAGGATGACAAACTCTTC
CTCAAAATCAACGGCTCGTCCAACCAGGAGGCCTTCGTGTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AB120364

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_2_Locus:
17p13.3

# Macromolecular_Interacting_Partner_2_SNPs:
rs13342837; rs939564; rs1051820; rs7342891; rs2280457; rs1057123; rs1054541; rs4423477; rs8065481; rs4790713; rs9909877; rs6502794; rs7214236; rs4790653; rs8069863; rs4790232; rs4790712; rs8066678; rs4790715; rs11652773; rs2280461; rs9898376; rs3809800; rs8066066; rs5019940; rs8073151; rs9907798; rs6502826; rs9910358; rs1054539; rs11870087; rs4239049; rs9891989; rs11652817; rs2013905; rs7214201; rs11868468; rs17626180; rs7210368; rs9908061; rs11652194; rs5018812; rs17821354; rs12450869; rs7503031; rs11658414; rs2280456; rs876789; rs6502803; rs9905733; rs4790667; rs9893937; rs7219369; rs7209071; rs4239048; rs12603919; rs7222858; rs6502802; rs8068736; rs4790238; rs4790660; rs12450088; rs4790666; rs2003109; rs9899989; rs8076586; rs9903662; rs12451477; rs12943313; rs12450380; rs9911336; rs8064934; rs7223748; rs12946691; rs8081142; rs7222193; rs9709029; rs3760461; rs12940386; rs12939034; rs11651656; rs9709222; rs6502818; rs12946255; rs8075404; rs9709382; rs4790664; rs9904084; rs6502816; rs11871898; rs4790652; rs7503387; rs7214591; rs10445290; rs12941834; rs11871893; rs9896599; rs7216280; rs12939592; rs12950544; rs8076758; rs11656606; rs9894482; rs12603658; rs12453258; rs4790708; rs4790724; rs12942362; rs9902296; rs4790651; rs7503914; rs12940028; rs6502796; rs11656017; rs9911701; rs1054538; rs4790650; rs8072208; rs8065694; rs11871321; rs8075750; rs11654602; rs7211336; rs8070038; rs7406591; rs9906910; rs12946826; rs9893867; rs6502793; rs4790733; rs4790732; rs7214099; rs34412033; rs12936338; rs36013798; rs3180367; rs5818817; rs4995767; rs4790241; rs4790727; rs1051844; rs9893731; rs12453377; rs9895731; rs35952871; rs5018811; rs34062926; rs34123904; rs35986054; rs4790658; rs4790237; rs35701443; rs4790717; rs34454811; rs34897893; rs7224876; rs12944516; rs8065678; rs35473964; rs10534238; rs9893515; rs9893037; rs2002673; rs10669185; rs35529287; rs33950123; rs4790668; rs9892753; rs12951283; rs5818807; rs5019939; rs12946197; rs12946736; rs8078489; rs11870394; rs12952141; rs12948388; rs35004462; rs35758739; rs35637670; rs11377420; rs9709201; rs34034048; rs11869773; rs33959232; rs28588675; rs35737749; rs11868782; rs28798822; rs35711534; rs12949271; rs5818811; rs10667483; rs35832030; rs11321695; rs28376510; rs11868411; rs35181236; rs5818816; rs7213088; rs4790703; rs34288494; rs8078582; rs36105596; rs4790228; rs7211755; rs3809799; rs4353527; rs4602094; rs11657591; rs4994702; rs10542912; rs35826381; rs36066390; rs10691065; rs9709023; rs34146054; rs12946735; rs7210633; rs35740453; rs5818812; rs10581796; rs7406994; rs12952332; rs9890424; rs12948799; rs12952338; rs35178364; rs12946322; rs35159020; rs7213112; rs35007897; rs4790208; rs11327685; rs35942409; rs5818815; rs4790227; rs4290528; rs35969643; rs12939321; rs4790661; rs35479391; rs9893753; rs34155198; rs4790720; rs12937576; rs35780448; rs12938875; rs5818808; rs34417483; rs35833132; rs11463729; rs10556012; rs11870396; rs12951553; rs35775166; rs4452014; rs9709111; rs35314868; rs4790669; rs12939032; rs9911948; rs35844335; rs12601048; rs9903190; rs35703900; rs4790226; rs9897632; rs35348910; rs35157880; rs34481585; rs35312453; rs34645328; rs1107765; rs13340988; rs13341542; rs34297715; rs34849297; rs35455643; rs35874481; rs36108564; rs3744643; rs3744644; rs3760460; rs4790250; rs7210066; rs7220535; rs7222425; rs8072430; rs8078917; rs9889287; rs9902471; rs9910870; rs9912776

# Macromolecular_Interacting_Partner_2_General_References:
Not Available

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8881

# Macromolecular_Interacting_Partner_3_Name:
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

# Macromolecular_Interacting_Partner_3_Synonyms:
Amino acid transporter ATB0+; Solute carrier family 6 member 14

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC6A14

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Sodium and chloridedependent neutral and basic amino acid transporter B0+
MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVW
RFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGIT
MVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNK
GIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLA
LCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQ
SNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVF
AGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLG
LDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHF
CAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAI
FIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCC
RPASNWGPYLEQHRGERYKDMVDPKKEADHEIPTVSGSRKPE

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
642

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
72154

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
8.27

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
 Function:  transporter activity
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_3_Signals:
1-469

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
45-65
72-92
110-130
235-255
261-281
315-335
348-368
399-419
450-477
480-500
528-548
563-583

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
5732680

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
S6A14_HUMAN (Q9UN76)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC6A14

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC6A14

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:11047

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1929 bp
ATGGACAAGTTGAAATGCCCGAGTTTCTTCAAGTGCAGGGAGAAGGAGAAAGTGTCGGCT
TCATCAGAGAATTTCCATGTTGGTGAAAATGATGAGAATCAGGACCGTGGTAACTGGTCC
AAAAAATCGGATTATCTTCTATCTATGATTGGATACGCAGTGGGATTAGGAAATGTGTGG
AGATTTCCATATCTGACCTACAGCAATGGTGGAGGCGCCTTCTTGATACCTTATGCAATT
ATGTTAGCATTGGCTGGTTTACCTTTGTTCTTTCTGGAGTGTTCACTGGGACAATTTGCT
AGCTTAGGTCCAGTTTCAGTTTGGAGGATTCTTCCATTGTTTCAAGGTGTGGGAATTACA
ATGGTCCTGATCTCCATTTTTGTGACAATCTATTACAATGTCATAATTGCCTATAGTCTT
TACTACATGTTTGCTTCTTTTCAAAGTGAACTACCATGGAAAAATTGTTCTTCGTGGTCA
GATAAAAACTGTAGCAGATCACCAATAGTAACTCACTGTAATGTGAGTACAGTGAATAAA
GGAATACAAGAGATCATCCAAATGAATAAAAGCTGGGTAGACATCAACAATTTTACCTGC
ATCAACGGCAGTGAAATTTATCAGCCAGGGCAGCTTCCCAGTGAACAATATTGGAATAAA
GTGGCGCTCCAACGGTCAAGTGGAATGAATGAGACTGGAGTAATTGTTTGGTATTTAGCA
CTTTGTCTTCTTCTGGCTTGGCTCATAGTTGGAGCAGCACTATTTAAAGGAATCAAATCG
TCTGGCAAGGTGGTATATTTTACAGCTCTTTTCCCCTATGTGGTCCTACTCATCCTGTTA
GTACGAGGTGCAACTCTGGAGGGTGCTTCAAAAGGCATTTCATACTATATTGGAGCCCAG
TCAAATTTTACAAAACTTAAGGAAGCTGAGGTATGGAAAGATGCTGCCACTCAGATATTT
TACTCCCTTTCAGTGGCTTGGGGTGGCTTAGTTGCTCTATCATCTTACAATAAGTTCAAA
AACAACTGCTTCTCTGATGCCATTGTGGTTTGTTTGACAAACTGTCTCACTAGCGTGTTT
GCTGGATTTGCTATTTTTTCTATATTGGGACACATGGCCCATATATCTGGAAAGGAAGTT
TCTCAAGTTGTAAAATCAGGTTTTGATTTGGCATTCATTGCCTATCCAGAGGCTCTAGCC
CAACTCCCAGGTGGTCCATTTTGGTCCATATTATTTTTTTTCATGCTTTTAACTTTGGGT
CTCGATTCTCAGTTTGCTTCGATTGAAACGATCACAACAACAATTCAAGATTTATTTCCC
AAAGTGATGAAGAAAATGAGGGTTCCCATAACTTTGGGCTGCTGCTTGGTTTTGTTTCTC
CTTGGTCTCGTCTGTGTGACTCAGGCTGGAATTTACTGGGTTCATCTGATTGACCACTTC
TGTGCTGGATGGGGCATTTTAATTGCAGCTATACTGGAGCTAGTTGGAATCATCTGGATT
TATGGAGGGAACAGATTCATTGAGGATACAGAAATGATGATTGGAGCAAAGAGGTGGATA
TTCTGGCTATGGTGGAGAGCTTGCTGGTTTGTAATTACGCCTATCCTTTTGATTGCAATA
TTTATCTGGTCATTGGTGCAATTTCATAGACCTAATTATGGCGCAATTCCATACCCTGAC
TGGGGAGTTGCTTTAGGCTGGTGTATGATTGTTTTCTGCATTATTTGGATACCAATTATG
GCTATCATAAAAATAATTCAGGCTAAAGGAAACATCTTTCAACGCCTTATAAGTTGCTGC
AGACCAGCTTCTAACTGGGGTCCATACCTGGAACAACATCGTGGGGAAAGATATAAAGAC
ATGGTAGATCCTAAAAAAGAGGCTGACCATGAAATACCTACTGTTAGTGGCAGCAGAAAA
CCGGAATGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF151978

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_3_Locus:
Xq23-q24

# Macromolecular_Interacting_Partner_3_SNPs:
rs12720074; rs2011162; rs5905179; rs12710570; rs5905289; rs2011198; rs2312055; rs2032525; rs5905176; rs5905284; rs7059155; rs2071877; rs4824325; rs10217924; rs5905178; rs6608646; rs12392462; rs2312057; rs12391221; rs17242824; rs5905288; rs12559530; rs10218102; rs10521579; rs12710569; rs10521578; rs5905285; rs5952101; rs12720080; rs12720088; rs5952099; rs12720083; rs5905177; rs4824358; rs4824324; rs12720076; rs4824359; rs12720084; rs12720079; rs5952103; rs2312056; rs12720089; rs17095419; rs12393509; rs4824323; rs2312054; rs7052454; rs12710568; rs12720073; rs12834312; rs3788766; rs5905283; rs12720085; rs28523889; rs6608648; rs11350870; rs34685017; rs28699570; rs12720092; rs28628632; rs12720078; rs5952174; rs35604008; rs5952104; rs5905287; rs6608645; rs12388847; rs10629819; rs12720087; rs12720091; rs35269408; rs17308739; rs3043424; rs35542990; rs5952100; rs5952102; rs35201069; rs6651554; rs12720077; rs10218234; rs6608647; rs12858125; rs34117081; rs5952175; rs12720082; rs34490652; rs4068397; rs7066547; rs7054956; rs12832551; rs10218418; rs12720075; rs12720086; rs12720090; rs35315031; rs7062559; rs10218017; rs12390279; rs12833869; rs12835480; rs12839137; rs12844003; rs17308697; rs2103697; rs2301451; rs5952181; rs6520234; rs6608511; rs6608514; rs6608644; rs6608650

# Macromolecular_Interacting_Partner_3_General_References:
10446133

# Macromolecular_Interacting_Partner_3_References:
Not Available

End of HMDB00172

Beginning of HMDB00173
# Accession_No:
HMDB00173

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-24 11:41:27

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Lactosylceramide

# Description:
A glycosphingolipid (ceramide and oligosaccharide)or oligoglycosylceramide with one or more sialic acids (i.e. n-acetylneuraminic acid) linked on the sugar chain. It is a component the cell plasma membrane which modulates cell signal transduction events. Gangliosides have been found to be highly important in immunology. Ganglioside GL2a carries a net-negative charge at pH 7.0 and is acidic. Gangliosides can amount to 6% of the weight of lipids from brain, but they are found at low levels in all animal tissues.

# Synonyms:
1-O-(4-O-b-D-galactopyranosyl-b-D-glucopyranosyl)-Ceramide; 1-O-(4-O-beta-D-Galactopyranosyl-beta-glucopyranosyl)ceramide; D-Galactosyl-1,4-beta-D-glucosylceramide; Ganglioside GA3; Ganglioside GL2a; Lactosyl-N-acylsphingosine; Lactosylceramide N-Lignoceryl sphingosyl lactoside; beta-D-Galactosyl-1,4-beta-D-glucosylceramide; 1-O-(4-O-beta-delta-galactopyranosyl-beta-delta-glucopyranosyl)-Ceramide; 1-O-(4-O-beta-delta-Galactopyranosyl-beta-glucopyranosyl)ceramide; delta-Galactosyl-1,4-beta-delta-glucosylceramide; beta-delta-Galactosyl-1,4-beta-delta-glucosylceramide

# Chemical_IUPAC_Name:
N-[(E)-1-[(2R,3R,4R,5R,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-oxan-2-yl]oxy-3-hydroxy-octadec-4-en-2-yl]octadecanamide

# Chemical_Formula:
C48H91NO13

# Chemical_Structure:
tbl_chemical:::HMDB00173_ZOOM.png:::117884218351179909

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00173_THUMB.png:::117884218108027263

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Glycosphingolipids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
acetal; primary alcohol; secondary alcohol; 1,2-diol; secondary carboxylic acid amide; alkene; heterocyclic compound

# Taxonomy_Biofunction:
Component of Ganglioside biosynthesis; Component of Glycosphingolipid metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
889.64905

# Molecular_Weight_Avg:
890.23505

# Smiles_String_isomeric:
CCCCCCCCCCCCCCCCCC(=O)NC(CO[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)CO)OC2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O)O)O)O)C(C=CCCCCCCCCCCCCC)O

# Smiles_String_canonical:
CCCCCCCCCCCCCCCCCC(=O)NC(COC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)CO)O)O)O)O)O)C(C=CCCCCCCCCCCCCC)O

# KEGG_Compound_ID:
C01290

# BioCyc_ID:
CYTOLIPIN_H

# PubChem_CID:
6450208

# PubChem_SID:
15040047; 3885461; 4509

# OMIM_ID:
602300; 604402; 245200

# Metagene_ID:
METACHROMATIC LEUKODISTROPHIES: 30

# BiGG_ID:
Not Available

# Wikipedia_ID:
Not Available

# METLIN_ID:
Not Available

# Ref_ID:
10320813; 1155085; 12070301; 12383912; 12409508; 12417418; 12438625; 12486134; 12566244; 12829005; 15695328; 1581306; 15918012; 16166299; 1854798; 3088302; 3569516; 6097589; 6107184; 6276; 6423755; 6794884; 6816790; 9106497

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
4682-48-8

# InChI:
InChI=1/C48H91NO13/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-40(53)49-36(37(52)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2)35-59-47-45(58)43(56)46(39(34-51)61-47)62-48-44(57)42(55)41(54)38(33-50)60-48/h29,31,36-39,41-48,50-52,54-58H,3-28,30,32-35H2,1-2H3,(H,49,53)/b31-29+/t36u,37?,38-,39-,41+,42+,43-,44-,45-,46+,47-,48?/m1/s1/f/h49H

# Synthesis_Reference:
Journal of the American Chemical Society  (1988),  110(23),  7910-12.

# Melting_Point:
Not Available

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
7.07e-03 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
6.26 [Predicted by ALOGPS]; 8.625 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00173.mol:::117503895053071420

# SDF_File_[Text]:
tbl_chemical:::HMDB00173.sdf:::117503895053951749

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00173_PDB.txt:::1132720758156861455

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Lactosylceramide.gif:::116076982310044152

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00173_peaks.txt:::1164782265923217793

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Lactosylceramide_C.gif:::11607698231263746

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00173_peaks.txt:::1164782423602897658

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane

# Tissue_Location:
Adrenal Gland; Brain; Fibroblasts; Nerve Cells; Neurons

# deuterated:
No

# Biofluid_Location:
Blood

# Concentration_[Normal]:
Blood	4.5 +/- 2.0	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Gaucher Disease; Krabbe Disease; Ulcerative Colitis

# Pathway_Names:
Aminosugars metabolism;Galactose metabolism;Glycerolipid metabolism;Glycosphingolipid metabolism

# Pathway_Images:
;;;

# KEGG_Images:
map00530;map00052;map00561;map00600

# Pathway_Graphs:
;;;

# Pathway_SBMLs:
;;;

# Metabolic_Enzyme_1_ID:
6153

# Metabolic_Enzyme_1_Name:
Beta-hexosaminidase beta chain precursor

# Metabolic_Enzyme_1_Synonyms:
N-acetyl-beta- glucosaminidase; Beta-N-acetylhexosaminidase; Hexosaminidase B; Cervical cancer proto-oncogene 7; HCC-7[Contains: Beta- hexosaminidase beta-B chain; Beta-hexosaminidase beta-A chain]

# Metabolic_Enzyme_1_Gene_Name:
HEXB

# Metabolic_Enzyme_1_Protein_Sequence:
>Betahexosaminidase beta chain precursor
MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLP
LSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQA
KTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVY
QDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVD
DQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGK
GQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKC
WESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTI
VEVWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQL
FIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERG
IAAQPLYAGYCNHENM

# Metabolic_Enzyme_1_Number_of_Residues:
556

# Metabolic_Enzyme_1_Molecular_Weight:
63112

# Metabolic_Enzyme_1_Theoretical_pI:
6.75

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  hexosaminidase activity
Function:  beta-N-acetylhexosaminidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues

# Metabolic_Enzyme_1_Pathway:
map00511  N-Glycan degradation;
 map00530  Aminosugars metabolism;
 map00531  Glycosaminoglycan degradation;
 map00603  Globoside metabolism

# Metabolic_Enzyme_1_Reaction:
Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00728:Glyco_hydro_20;
PF02838:Glyco_hydro_20b

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
13-35

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.2.1.52

# Metabolic_Enzyme_1_GenBank_ID_Protein:
179462

# Metabolic_Enzyme_1_SwissProt_ID:
HEXB_HUMAN (P07686)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
HEXB

# Metabolic_Enzyme_1_Geneatlas_id:
HEXB

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4879

# Metabolic_Enzyme_1_PDB_ID:
1O7A

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_1_Gene_Sequence:
>1719 bp
GTCCCGAGGCTCCGGCTCGGCAGACCGGGCGGAAAGCAGCCGAGCGGCCATGGAGCTGTG
CGGGCTGGGGCTGCCCCGGCCGCCCATGCTGCTGGCGCTGCTGTTGGCGACATGCTGGCG
GCGATGTTGGCGCTGCTGACTCAGGTGGCGCTGGTGGTGCAGGTGGCGGAGGCGGCTCGG
GCCCCGAGCGTCTCGGCCAAGCCGGGGCCGGCGCTGTGGCCCCTGCCGCTCTCGGTGAAG
ATGACCCCGAACCTGCTGCATCTCGCCCCGGAGAACTTCTACATCAGCCACAGCCCCAAT
TCCACGGCGGGCCCCTCCTGCACCCTGCTGGAGGAAGCGTTTCGACGATATCATGGCTAT
ATTTTTGGTTTCTACAAGTGGCATCATGAACCTGCTGAATTCCAGGCTAAAACCCAGGTT
CAGCAACTTCTTGTCTCAATCACCCTTCAGTCAGAGTGTGATGCTTTCCCCAACATATCT
TCAGATGAGTCTTATACTTTACTTGTGAAAGAACCAGTGGCTGTCCTTAAGGCCAACAGA
GTTTGGGGAGCATTACGAGGTTTAGAGACCTTTAGCCAGTTAGTTTATCAAGATTCTTAT
GGAACTTTCACCATCAATGAATCCACCATTATTGATTCTCCAAGGTTTTCTCACAGAGGA
ATTTTGATTGATACATCCAGACATTATCTGCCAGTTAAGATTATTCTTAAAACTCTGGAT
GCCATGGCTTTTAATAAGTTTAATGTTCTTCACTGGCACATAGTTGATGACCAGTCTTTC
CCATATCAGAGCATCACTTTTCCTGAGTTAAGCAATAAAGGAAGCTATTCTTTGTCTCAT
GTTTATACACCAAATGATGTCCGTATGGTGATTGAATATGCCAGATTACGAGGAATTCGA
GTCCTGCCAGAATTTGATACCCCTGGGCATACACTATCTTGGGGAAAAGGTCAGAAAGAC
CTCCTGACTCCATGTTACAGTAGACAAAACAAGTTGGACTCTTTTGGACCTATAAACCCT
ACTCTGAATACAACATACAGCTTCCTTACTACATTTTTCAAAGAAATTAGTGAGGTGTTT
CCAGATCAATTCATTCATTTGGGAGGAGATGAAGTGGAATTTAAATGTTGGGAATCAAAT
CCAAAAATTCAAGATTTCATGAGGCAAAAAGGCTTTGGCACAGATTTTAAGAAACTAGAA
TCTTTCTACATTCAAAAGGTTTTGGATATTATTGCAACCATAAACAAGGGATCCATTGTC
TGGCAGGAGGTTTTTGATGATAAAGCAAAGCTTGCGCCGGGCACAATAGTTGAAGTATGG
AAAGACAGCGCATATCCTGAGGAACTCAGTAGAGTCACAGCATCTGGCTTCCCTGTAATC
CTTTCTGCTCCTTGGTACTTAGATTTGATTAGCTATGGACAAGATTGGAGGAAATACTAT
AAAGTGGAACCTCTTGATTTTGGCGGTACTCAGAAACAGAAACAACTTTTCATTGGTGGA
GAAGCTTGTCTATGGGGAGAATATGTGGATGCAACTAACCTCACTCCAAGATTATGGCCT
CGGGCAAGTGCTGTTGGTGAGAGACTCTGGAGTTCCAAAGATGTCAGAGATATGGATGAC
GCCTATGACAGACTGACAAGGCACCGCTGCAGGATGGTCGAACGTGGAATAGCTGCACAA
CCTCTTTATGCTGGATATTGTAACCATGAGAACATGTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M13519

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_1_Locus:
5q13

# Metabolic_Enzyme_1_SNPs:
rs10805890; rs820878; rs11556045; rs820879; rs820883; rs820885; rs12519436; rs820880; rs11742621; rs6453074; rs3733791; rs11746757; rs820884; rs7710892; rs820882; rs3756443; rs6867972; rs820830; rs820876; rs11746069; rs820827; rs820887; rs820886; rs12517888; rs17561000; rs16872206; rs848903; rs1665894; rs17738111; rs3756444; rs3776484; rs820829; rs820831; rs820837; rs6453073; rs1696979; rs11746717; rs820881; rs13154639; rs1566431; rs820826; rs13186984; rs13169585; rs820834; rs12518926; rs820889; rs16872211; rs820825; rs11749435; rs13360054; rs2972329; rs11749240; rs16872213; rs13178702; rs820838; rs820833; rs820877; rs11746583; rs11747101; rs17670605; rs13188271; rs11955177; rs1665886; rs11743615; rs820888; rs861058; rs12516258; rs820835; rs10942718; rs820828; rs12521189; rs820832; rs11959570; rs13165466; rs11949631; rs1094147; rs1665885; rs820839; rs820870; rs2936918; rs820869; rs820871; rs820874; rs820872; rs16872198; rs820868; rs820867; rs11556043; rs35280836; rs34142144; rs35119423; rs35711978; rs11410256; rs34681065; rs6860453; rs5868752; rs1094146; rs1104272; rs35044539; rs11421445; rs35889292; rs1823201; rs6877999; rs11397975; rs34363294; rs6870622; rs35739611; rs11960152; rs820875; rs35668424; rs11959392; rs13161025; rs41271747; rs13154625; rs34073116; rs35957975; rs6870452; rs6870965; rs13153243; rs36095303; rs35607163; rs35047903; rs34492012; rs33916868; rs5868750; rs35812692; rs820836; rs3104693; rs3834249; rs13179930; rs11454581; rs36118532; rs34431850; rs11324226; rs35339652; rs34187493; rs5030731; rs35579913; rs34754618; rs33923006; rs10646161; rs5868751; rs3776481; rs34812931; rs36038658; rs41271749; rs2442041; rs34601490; rs34279783; rs10644603; rs35641826; rs35757357; rs11957259; rs1094145; rs34968963; rs34934079; rs6870609; rs12514776; rs10041807; rs6889101; rs34022383; rs34849701; rs2593642; rs16872203; rs2593641; rs4063869; rs16872201; rs4063871; rs35751282; rs1048088; rs1048167; rs10515189; rs10942717; rs1164691; rs11738782; rs11743655; rs11746611; rs11748460; rs11749103; rs11750747; rs11948122; rs12233980; rs12233981; rs16872194; rs16872220; rs17670514; rs34172202; rs34845453; rs35080306; rs3846655; rs3846656; rs3894712; rs4460123; rs6897850; rs6898989; rs7349790; rs7445920; rs7706616; rs820840; rs820864; rs820866

# Metabolic_Enzyme_1_General_References:
3013851; 2977375; 2964638; 2971039; 2147427; 2966076; 2139028; 2525487; 2965147; 2579389; 2971395; 12754519; 11447134; 8673609; 1825792; 1720305; 1531140; 8357844; 7626071; 7557963; 7633435; 8950198; 9401004; 9856491; 9694901

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6154

# Metabolic_Enzyme_2_Name:
Beta-hexosaminidase alpha chain precursor

# Metabolic_Enzyme_2_Synonyms:
N-acetyl- beta-glucosaminidase; Beta-N-acetylhexosaminidase; Hexosaminidase A

# Metabolic_Enzyme_2_Gene_Name:
HEXA

# Metabolic_Enzyme_2_Protein_Sequence:
>Betahexosaminidase alpha chain precursor
MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV
LDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTI
NDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHY
LPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVK
EVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEF
MSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLL
DIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPW
YLNRISYGPDWKDFYVVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAV
AERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT

# Metabolic_Enzyme_2_Number_of_Residues:
529

# Metabolic_Enzyme_2_Molecular_Weight:
60689

# Metabolic_Enzyme_2_Theoretical_pI:
4.79

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  hexosaminidase activity
Function:  beta-N-acetylhexosaminidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity

# Metabolic_Enzyme_2_Pathway:
map00511  N-Glycan degradation;
 map00530  Aminosugars metabolism;
 map00531  Glycosaminoglycan degradation;
 map00603  Globoside metabolism

# Metabolic_Enzyme_2_Reaction:
Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00728:Glyco_hydro_20;
PF02838:Glyco_hydro_20b

# Metabolic_Enzyme_2_Signals:
1-22

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.2.1.52

# Metabolic_Enzyme_2_GenBank_ID_Protein:
179460

# Metabolic_Enzyme_2_SwissProt_ID:
HEXA_HUMAN (P06865)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
HEXA

# Metabolic_Enzyme_2_Geneatlas_id:
HEXA

# Metabolic_Enzyme_2_hgnc_id:
HGNC:4878

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_2_Gene_Sequence:
>1475 bp
TTACCCGAACAACTTTCAATTCCAGTACGATGTCAGCTCGGCCGCGCAGCCCGGCTGCTC
AGTCCTCGACGAGGCCTTCCAGCGCTATCGTGACCTGCTTTTCGGTTCCGGGTCTTGGCC
CCGTCCTTACCTCACAGGGAAACGGCATACACTGGAGAAGAATGTGTTGGTTGTCTCTGT
AGTCACACCTGGATGTAACCAGCTTCCTACTTTGGAGTCAGTGGAGAATTATACCCTGAC
CATAAATGATGACCAGTGTTTACTCCTCTCTGAGACTGTCTGGGGAGCTCTCCGAGGTCT
GGAGACTTTTAGCCAGCTTGTTTGGAAATCTGCTGAGGGCACATTCTTTATCAACAAGAC
TGAGATTGAGGACTTTCCCCGCTTTCCTCACCGGGGCTTGCTGTTGGATACATCTCGCCA
TTACCTGCCACTCTCTAGCATCCTGGACACTCTGGATGTCATGGCGTACAATAAATTGAA
CGTGTTCCACTGGCATCTGGTAGATGATCCTTCCTTCCCATATGAGAGCTTCACTTTTCC
AGAGCTCATGAGAAAGGGGTCCTACAACCCTGTCACCCACATCTACACAGCACAGGATGT
GAAGGAGGTCATTGAATACGCACGGCTCCGGGGTATCCGTGTGCTTGCAGAGTTTGACAC
TCCTGGCCACACTTTGTCCTGGGGACCAGGTATCCCTGGATTACTGACTCCTTGCTACTC
TGGGTCTGAGCCCTCTGGCACCTTTGGACCAGTGAATCCCAGTCTCAATAATACCTATGA
GTTCATGAGCACATTCTTCTTAGAAGTCAGCTCTGTCTTCCCAGATTTTTATCTTCATCT
TGGAGGAGATGAGGTTGATTTCACCTGCTGGAAGTCCAACCCAGAGATCCAGGACTTTAT
GAGGAAGAAAGGCTTCGGTGAGGACTTCAAGCAGCTGGAGTCCTTCTACATCCAGACGCT
GCTGGACATCGTCTCTTCTTATGGCAAGGGCTATGTGGTCTGGCAGGAGGTGTTTGATAA
TAAAGTAAAGATTCAGCCAGACACAATCATACAGGTGTGGCGAGAGGATATTCCAGTGAA
CTATATGAAGGAGCTGGAACTGGTCACCAAGGCCGGCTTCCGGGCCCTTCTCTCTGCCCC
CTGGTACCTGAACCGTATATCCTATGGCCCTGACTGGAAGGATTTCTACGTAGTGGAACC
CCTGGCATTTGAAGGTACCCCTGAGCAGAAGGCTCTGGTGATTGGTGGAGAGGCTTGTAT
GTGGGGAGAATATGTGGACAACACAAACCTGGTCCCCAGGCTCTGGCCCAGAGCAGGGGC
TGTTGCCGAAAGGCTGTGGAGCAACAAGTTGACATCTGACCTGACATTTGCCTATGAACG
TTTGTCACACTTCCGCTGTGAGTTGCTGAGGCGAGGTGTCCAGGCCCAACCCCTCAATGT
AGGCTTCTGTGAGCAGGAGTTTGAACAGACCTGAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M13520

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_2_Locus:
15q23-q24

# Metabolic_Enzyme_2_SNPs:
rs1800431; rs1800430; rs4777502; rs3087652; rs11629508; rs962407; rs4777503; rs2114208; rs10467945; rs4777504; rs4265763; rs963375; rs2288258; rs8037749; rs10438367; rs16956788; rs12899167; rs9806374; rs10220850; rs1972692; rs16956783; rs11857752; rs9806212; rs16956826; rs10468051; rs2288259; rs2303450; rs11072360; rs2912217; rs11633028; rs12437909; rs2303448; rs10220917; rs6495002; rs12593333; rs16956794; rs12915032; rs12592727; rs12440768; rs12904378; rs17823279; rs3784586; rs12439220; rs2912218; rs7174287; rs12908883; rs16956771; rs16956759; rs11636684; rs10438368; rs12904685; rs12441745; rs2303449; rs12441854; rs13379855; rs11072359; rs2912216; rs1054374; rs1800429; rs28940871; rs11551324; rs28942072; rs34085965; rs35949555; rs1054432; rs34300017; rs35005352; rs28540068; rs4776595; rs4129927; rs12902983; rs7175232; rs12910617; rs12915082; rs11299619; rs35827424; rs28471053; rs12910921; rs7497643; rs8039489; rs28420794; rs34607939; rs28445620; rs12898849; rs35649102; rs12900324; rs12898977; rs36106892; rs35729578; rs890313; rs34206496; rs12902886; rs12903250; rs12899150; rs34004907; rs12900308; rs12912278; rs34110830; rs12899418; rs35118677; rs11326230; rs4776594; rs2013537; rs28479635; rs2114209; rs1114154; rs36091525; rs34093438; rs12899116; rs4470105; rs34736306; rs2959905; rs13380343; rs7180191; rs11632505; rs11635534; rs11636261; rs12910979; rs16956723; rs16956866; rs16956884; rs1800428; rs2912214; rs2959911; rs35486349; rs3743230; rs4442765; rs4508386; rs4776592; rs4776593; rs4777500; rs4777501; rs4777505; rs4777506; rs4777507; rs7172504

# Metabolic_Enzyme_2_General_References:
2933746; 1833974; 3013851; 2952641; 2965147; 2971395; 1533633; 8652542; 8673609; 1825792; 9090523; 2970528; 2522679; 2144098; 1837283; 1532289; 1384323; 1302612; 1301189; 1301190; 7902672; 8490625; 8445615; 7951261; 7837766; 7717398; 8581357; 7898712; 8757036; 9150157; 9338583; 9375850; 9401008; 9603435; 14566483

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6051

# Metabolic_Enzyme_3_Name:
Lactosylceramide alpha-2,3-sialyltransferase

# Metabolic_Enzyme_3_Synonyms:
CMP- NeuAc:lactosylceramide alpha-2,3-sialyltransferase; Ganglioside GM3 synthase; ST3Gal V; Sialyltransferase 9

# Metabolic_Enzyme_3_Gene_Name:
ST3GAL5

# Metabolic_Enzyme_3_Protein_Sequence:
>Lactosylceramide alpha2,3sialyltransferase
MRRPSLLLKDILKCTLLVFGVWILYILKLNYTTEECDMKKMHYVDPDHVKRAQKYAQQVL
QKECRPKFAKTSMALLFEHRYSVDLLPFVQKAPKDSEAESKYDPPFGFRKFSSKVQTLLE
LLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGN
KTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVA
EKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEV
SLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKLVKEGVVKDLSGGIDR
EF

# Metabolic_Enzyme_3_Number_of_Residues:
362

# Metabolic_Enzyme_3_Molecular_Weight:
41736

# Metabolic_Enzyme_3_Theoretical_pI:
8.62

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  sialyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  intrinsic to organelle membrane
Component:  intrinsic to Golgi membrane
Component:  integral to Golgi membrane

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D- glucosylceramide)

# Metabolic_Enzyme_3_Pathway:
map00604  Ganglioside biosynthesis

# Metabolic_Enzyme_3_Reaction:
CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00777:Glyco_transf_29

# Metabolic_Enzyme_3_Signals:
1-32

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.4.99.9

# Metabolic_Enzyme_3_GenBank_ID_Protein:
3779139

# Metabolic_Enzyme_3_SwissProt_ID:
SIAT9_HUMAN (Q9UNP4)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ST3GAL5

# Metabolic_Enzyme_3_Geneatlas_id:
ST3GAL5

# Metabolic_Enzyme_3_hgnc_id:
HGNC:10872

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Potential)

# Metabolic_Enzyme_3_Gene_Sequence:
>1089 bp
ATGAGAAGGCCCAGCTTGTTATTAAAAGACATCCTCAAATGTACATTGCTTGTGTTTGGA
GTGTGGATCCTTTATATCCTCAAGTTAAATTATACTACTGAAGAATGTGACATGAAAAAA
ATGCATTATGTGGACCCTGACCGTGTAAAGAGAGCTCAGAAATATGCTCAGCAAGTCTTG
CAGAAGGAATGTCGTCCCAAGTTTGCCAAGACATCAATGGCGCTGTTATTTGAGCACAGG
TATAGCGTGGACTTACTCCCTTTTGTGCAGAAGGCCCCCAAAGACAGTGAAGCTGAGTCC
AAGTACGATCCTCCTTTTGGGTTCCGGAAGTTCTCCAGTAAAGTCCAGACCCTCTTGGAA
CTCTTGCCAGAGCACGACCTCCCTGAACACTTGAAAGCCAAGACCTGTCGGCGCTGTGTG
GTTATTGGAAGCGGAGGAATACTGCACGGATTAGAACTGGGCCACACCCTGAACCAGTTC
GATGTTGTGATAAGGTTAAACAGTGCACCAGTTGAGGGATATTCAGAACATGTTGGAAAT
AAAACTACTATAAGGATGACTTATCCAGAGGGCGCACCACTGTCTGACCTTGAATATTAT
TCCAATGACTTATTTGTTGCTGTTTTATTTAAGAGTGTTGATTTCAACTGGCTTCAAGCA
ATGGTAAAAAAGGAAACCCTGCCATTCTGGGTACGACTCTTCTTTTGGAAGCAGGTGGCA
GAAAAAATCCCACTGCAGCCAAAACATTTCAGGATTTTGAATCCAGTTATCATCAAAGAG
ACTGCCTTTGACATCCTTCAGTACTCAGAGCCTCAGTCAAGGTTCTGGGGCCGAGATAAG
AACGTCCCCACAATCGGTGTCATTGCCGTTGTCTTAGCCACACATCTGTGCGATGAAGTC
AGTTTGGCGGGTTTTGGATATGACCTCAATCAACCCAGAACACCTTTGCACTACTTCGAC
AGTCAATGCATGGCTGCTATGAACTTTCAGACCATGCATAATGTGACAACGGAAACCAAG
TTCCTCTTAAAGCTGGTCAAAGAGGGAGTGGTGAAAGATCTCAGTGGAGGCATTGATCGT
GAATTTTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
AB018356

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_3_Locus:
2p11.2

# Metabolic_Enzyme_3_SNPs:
rs3731824; rs2030275; rs4832211; rs11681961; rs4553826; rs1533605; rs4832213; rs4832015; rs6734488; rs1878904; rs6547636; rs6547635; rs17026728; rs11674097; rs11689889; rs12622987; rs12614498; rs6750686; rs6721125; rs6753350; rs6547638; rs11681915; rs3810821; rs2366948; rs10865479; rs6547637; rs12714153; rs11127009; rs10175609; rs12618873; rs1518991; rs6751743; rs6720161; rs6547639; rs10865480; rs7587003; rs13422640; rs12463901; rs1878905; rs4832215; rs17026729; rs10204648; rs11127008; rs7565996; rs6547640; rs4832016; rs11694341; rs6707472; rs11687628; rs6720628; rs11127006; rs11678865; rs1518990; rs1054936; rs3770094; rs13020072; rs4832210; rs12613609; rs6753528; rs10496319; rs7561062; rs2280316; rs10203518; rs6716233; rs2366947; rs6547634; rs2280315; rs3770093; rs12990400; rs2280314; rs3770092; rs17026675; rs13028295; rs13025142; rs7572209; rs10496320; rs17026684; rs13014890; rs3770096; rs17026666; rs11694145; rs13014421; rs10179419; rs6759239; rs7558479; rs3770097; rs17026701; rs12478916; rs11679283; rs2176627; rs1000374; rs12714154; rs4832216; rs28364795; rs11127001; rs11127002; rs28364794; rs11674561; rs34172834; rs34410645; rs11894301; rs35521726; rs11893440; rs11127005; rs13025122; rs34467025; rs35974858; rs10698508; rs4432451; rs13024999; rs11891682; rs11298476; rs35899858; rs11127004; rs35912129; rs3046644; rs3202465; rs10693806; rs35093099; rs35327098; rs35628812; rs33930859; rs7600473; rs34207983; rs11127007; rs1533606; rs36072743; rs11127003; rs7586816; rs35466870; rs4446072; rs34120521; rs13016226; rs4832214; rs13024577; rs11893589; rs35528159; rs34584624; rs13024553; rs10553932; rs34971291; rs35268429; rs12992339; rs34082565; rs34403285; rs13033743; rs35487160; rs34896754; rs35817943; rs2280313; rs13191; rs10696470; rs35707118; rs3046619; rs35493914; rs34292806; rs34737048; rs35086875; rs9677117; rs35477883; rs36008111; rs35483582; rs3046643; rs34980443; rs2280312; rs12997361; rs35921749; rs13007131; rs13015450; rs35844245; rs41291145; rs36078405; rs13014513; rs10696471; rs5832664; rs35683772; rs13034643; rs11674537; rs10171816; rs10175249; rs11683466; rs13031939; rs13420465; rs1401383; rs1401385; rs1543972; rs1607466; rs1878898; rs2139201; rs2366949; rs2438307; rs4832217; rs6726662; rs6735629; rs7572585; rs954176

# Metabolic_Enzyme_3_General_References:
9822625; 12975309

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
6124

# Metabolic_Enzyme_4_Name:
Beta-galactosidase precursor

# Metabolic_Enzyme_4_Synonyms:
Lactase; Acid beta- galactosidase

# Metabolic_Enzyme_4_Gene_Name:
GLB1

# Metabolic_Enzyme_4_Protein_Sequence:
>Betagalactosidase precursor
MPGFLVRILLLLLVLLLLGPTRGLRNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRV
PRFYWKDRLL
KMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVI
LRPGPYICAEWEMGGLPAWLL
EKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGG
PVITVQVENEYGSYFACDFDYLRFLQKRFRHH
LGDDVVLFTTDGAHKTFLKCGALQGLY
TTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQP
HSTIKTEAVASSLYDI
LARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFAL
RNIIQ
KFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGF
VLYRT
TLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLD
LLVENMGRVNYGAYIN
DFKGLVSNLTLSSNILTDWTIFPLDTEDAVRSHLGGWGHRDSG
HHDEAWAHNSSNYTLPAFYMGNFSIPS
GIPDLPQDTFIQFPGWTKGQVWINGFNLGRYW
PARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDD
PELCAVTFVDRPVIGSSVTYD
HPSKPVEKRLMPPPPQKNKDSWLDHV

# Metabolic_Enzyme_4_Number_of_Residues:
677

# Metabolic_Enzyme_4_Molecular_Weight:
76092

# Metabolic_Enzyme_4_Theoretical_pI:
6.55

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  galactosidase activity
Function:  beta-galactosidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  protein complex
Component:  unlocalized protein complex
Component:  beta-galactosidase complex

# Metabolic_Enzyme_4_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans

# Metabolic_Enzyme_4_Pathway:
map00052  Galactose metabolism;
 map00511  N-Glycan degradation;
 map00531  Glycosaminoglycan degradation;
 map00561  Glycerolipid metabolism;
 map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_4_Reaction:
Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01301:Glyco_hydro_35

# Metabolic_Enzyme_4_Signals:
1-23

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.2.1.23

# Metabolic_Enzyme_4_GenBank_ID_Protein:
179401

# Metabolic_Enzyme_4_SwissProt_ID:
BGAL_HUMAN (P16278)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
GLB1

# Metabolic_Enzyme_4_Geneatlas_id:
GLB1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:4298

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_4_Gene_Sequence:
>2034 bp

ATGCCGGGGTTCCTGGTTCGCATCCTCCTTCTGCTGCTGGTTCTGCTGCTTCTGGGCCC
TACGCGCGGCT
TGCGCAATGCCACCCAGAGGATGTTTGAAATTGACTATAGCCGGGACT
CCTTCCTCAAGGATGGCCAGCC
ATTTCGCTACATCTCAGGAAGCATTCACTACTCCCGT
GTGCCCCGCTTCTACTGGAAGGACCGGCTGCTG
AAGATGAAGATGGCTGGGCTGAACGC
CATCCAGACGTATGTGCCCTGGAACTTTCATGAGCCCTGGCCAG
GACAGTACCAGTTTT
CTGAGGACCATGATGTGGAATATTTTCTTCGGCTGGCTCATGAGCTGGGACTGCT
GGTT
ATCCTGAGGCCCGGGCCCTACATCTGTGCAGAGTGGGAAATGGGAGGATTACCTGCTTGG
CTGCTA
GAGAAAGAGTCTATTCTTCTCCGCTCCTCCGACCCAGATTACCTGGCAGCTGT
GGACAAGTGGTTGGGAG
TCCTTCTGCCCAAGATGAAGCCTCTCCTCTATCAGAATGGAG
GGCCAGTTATAACAGTGCAGGTTGAAAA
TGAATATGGCAGCTACTTTGCCTGTGATTTT
GACTACCTGCGCTTCCTGCAGAAGCGCTTTCGCCACCAT
CTGGGGGATGATGTGGTTCT
GTTTACCACTGATGGAGCACATAAAACATTCCTGAAATGTGGGGCCCTGC
AGGGCCTCT
ACACCACGGTGGACTTTGGAACAGGCAGCAACATCACAGATGCTTTCCTAAGCCAGAGGA
A
GTGTGAGCCCAAAGGACCCTTGATCAATTCTGAATTCTATACTGGCTGGCTAGATCAC
TGGGGCCAACCT
CACTCCACAATCAAGACCGAAGCAGTGGCTTCCTCCCTCTATGATAT
ACTTGCCCGTGGGGCGAGTGTGA
ACTTGTACATGTTTATAGGTGGGACCAATTTTGCCT
ATTGGAATGGGGCCAACTCACCCTATGCAGCACA
GCCCACCAGCTACGACTATGATGCC
CCACTGAGTGAGGCTGGGGACCTCACTGAGAAGTATTTTGCTCTG
CGAAACATCATCCA
GAAGTTTGAAAAAGTACCAGAAGGTCCTATCCCTCCATCTACACCAAAGTTTGCAT
ATG
GAAAGGTCACTTTGGAAAAGTTAAAGACAGTGGGAGCAGCTCTGGACATTCTGTGTCCCT
CTGGGCC
CATCAAAAGCCTTTATCCCTTGACATTTATCCAGGTGAAACAGCATTATGGG
TTTGTGCTGTACCGGACA
ACACTTCCTCAAGATTGCAGCAACCCAGCACCTCTCTCTTC
ACCCCTCAATGGAGTCCACGATCGAGCAT
ATGTTGCTGTGGATGGGATCCCCCAGGGAG
TCCTTGAGCGAAACAATGTGATCACTCTGAACATAACAGG
GAAAGCTGGAGCCACTCTG
GACCTTCTGGTAGAGAACATGGGACGTGTGAACTATGGTGCATATATCAAC
GATTTTAA
GGGTTTGGTTTCTAACCTGACTCTCAGTTCCAATATCCTCACGGACTGGACGATCTTTCC
AC
TGGACACTGAGGATGCAGTGCGCAGCCACCTGGGGGGCTGGGGACACCGTGACAGTG
GCCACCATGATGA
AGCCTGGGCCCACAACTCATCCAACTACACGCTCCCGGCCTTTTAT
ATGGGGAACTTCTCCATTCCCAGT
GGGATCCCAGACTTGCCCCAGGACACCTTTATCCA
GTTTCCTGGATGGACCAAGGGCCAGGTCTGGATTA
ATGGCTTTAACCTTGGCCGCTATT
GGCCAGCCCGGGGCCCTCAGTTGACCTTGTTTGTGCCCCAGCACAT
CCTGATGACCTCG
GCCCCAAACACCATCACCGTGCTGGAACTGGAGTGGGCACCCTGCAGCAGTGATGAT
CC
AGAACTATGTGCTGTGACGTTCGTGGACAGGCCAGTTATTGGCTCATCTGTGACCTACGA
TCATCCCT
CCAAACCTGTTGAAAAAAGACTCATGCCCCCACCCCCGCAAAAAAACAAAG
ATTCATGGCTGGACCATGT
ATGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M27507

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_4_Locus:
3p21.33

# Metabolic_Enzyme_4_SNPs:
rs4302331; rs35289681; rs4645101; rs6805519; rs7614585; rs3924695; rs4679075; rs9869052; rs4350874; rs6550204; rs4479543; rs9827863; rs9868526; rs4277638; rs6550200; rs4679074; rs6780220; rs7613051; rs6781225; rs6777787; rs4438612; rs6550203; rs9828592; rs4423716; rs7616912; rs7629880; rs4679082; rs4320035; rs9311003; rs9310999; rs6550202; rs6802807; rs6766207; rs3924696; rs6805766; rs4678613; rs6781531; rs6766191; rs4074708; rs6550191; rs13078132; rs9311001; rs4528891; rs4402881; rs4234266; rs7637435; rs6550205; rs4130167; rs9863198; rs9875798; rs12632196; rs6782510; rs9849898; rs1133253; rs4234262; rs9833676; rs11708012; rs9865921; rs9311002; rs4678868; rs4678660; rs12635761; rs9826234; rs11715310; rs6762132; rs7646283; rs9310998; rs10154834; rs11707667; rs13093517; rs4678657; rs11129544; rs4270461; rs9861960; rs11714207; rs12633904; rs13314478; rs7643224; rs12495572; rs4328758; rs13093698; rs4679076; rs9883177; rs13080709; rs4274702; rs6550199; rs11129542; rs9810375; rs11717007; rs11712996; rs4343578; rs6773715; rs9858362; rs9815409; rs13078515; rs13096312; rs4679077; rs6785135; rs9861316; rs13324134; rs4257495; rs11718295; rs9852589; rs4234267; rs9824270; rs9816051; rs9860199; rs9866187; rs7626612; rs9831065; rs9868815; rs9852081; rs7610177; rs4311175; rs9865232; rs9817993; rs9882717; rs9824218; rs7616228; rs6770187; rs9819337; rs4493381; rs6768988; rs7618005; rs4575834; rs12054351; rs35000357; rs6776757; rs13081593; rs4263242; rs9827128; rs6770614; rs13078446; rs9883376; rs4998983; rs11706136; rs9830701; rs4678652; rs7628722; rs4269037; rs6783481; rs7610270; rs4491851; rs13094148; rs6769803; rs9845011; rs12491500; rs6805872; rs9851902; rs9860184; rs9754700; rs6770682; rs9838286; rs9840748; rs9810955; rs9829197; rs11129543; rs12490111; rs4679097; rs9872578; rs4558698; rs9814670; rs9841000; rs34173901; rs4456812; rs9858291; rs11924625; rs4383462; rs4630893; rs6782297; rs4583587; rs4678644; rs6786613; rs7610916; rs7650543; rs11720449; rs4547648; rs9865113; rs11707205; rs7645956; rs34103134; rs4428129; rs11927929; rs4371463; rs13079353; rs4234264; rs11713054; rs6769787; rs9849213; rs9851459; rs12633200; rs9817393; rs6782318; rs9880004; rs9863331; rs12167; rs7643313; rs4678523; rs4678524; rs1803198; rs13073546; rs1803199; rs34421970; rs1803200; rs34204221; rs6776436; rs35360222; rs35516563; rs35949170; rs35217324; rs34064757; rs9681623; rs35066652; rs9879174; rs28457681; rs35366996; rs12636380; rs35546490; rs4411834; rs34170794; rs34840292; rs11706680; rs35079906; rs35567563; rs35096418; rs34190372; rs34267899; rs9835090; rs34542942; rs28564715; rs34783720; rs35299531; rs28752078; rs35609083; rs4404396; rs10596366; rs36061528; rs35625458; rs6550190; rs4678642; rs35791447; rs35543972; rs10702620; rs7612742; rs11387959; rs9875140; rs9858992; rs28538948; rs4472006; rs34081225; rs35480293; rs11443960; rs34301631; rs34629244; rs9836304; rs4678941; rs9825789; rs11927839; rs35111870; rs35849739; rs34459243; rs6767833; rs7431645; rs10683710; rs28488329; rs9825335; rs35781117; rs9872225; rs34491679; rs13077125; rs9858364; rs11342344; rs35553546; rs35894066; rs10559091; rs35313892; rs6800001; rs13079744; rs13062239; rs10662168; rs6772595; rs13059918; rs34558646; rs28615536; rs11303788; rs10679653; rs36181668; rs35688004; rs11414853; rs7610165; rs35269925; rs11348689; rs34388197; rs11459888; rs9852362; rs4678643; rs4130168; rs11328798; rs7621255; rs11276167; rs11915291; rs28727973; rs13092698; rs34500490; rs36036446; rs7610931; rs35201739; rs6785862; rs11428956; rs11385614; rs4234263; rs7619312; rs11717735; rs34139339; rs34827860; rs6776437; rs6770268; rs12054117; rs34097913; rs11416783; rs35555652; rs36140454; rs9848784; rs10613912; rs35419837; rs35291321; rs4613407; rs34772446; rs35570272; rs7650438; rs6792048; rs11289119; rs11707202; rs7646643; rs35879433; rs35844867; rs28420683; rs28617702; rs34103242; rs35684962; rs34958264; rs9845695; rs34986791; rs35533674; rs34652262; rs7628609; rs35507451; rs35777526; rs35835691; rs4298001; rs35847345; rs35580094; rs28372666; rs34648323; rs13098058; rs9865342; rs34547154; rs35399363; rs35548830; rs9811260; rs34925031; rs4130166; rs10661628; rs9849872; rs35026670; rs13072499; rs34482863; rs4447709; rs4508727; rs12487241; rs9831194; rs13082782; rs10529787; rs13314904; rs4234234; rs9873651; rs5847772; rs11423270; rs9850839; rs10528005; rs35809982; rs9838124; rs4678849; rs11711396; rs11715480; rs11718846; rs11914868; rs12635828; rs4075736; rs4578976; rs4678677; rs4678774; rs6769735; rs6793913; rs7612234; rs7614776; rs9860567

# Metabolic_Enzyme_4_General_References:
2511208; 2111707; 3143362; 10841810; 10571006; 1928092; 1909089; 1907800; 1487238; 8213816; 8198123; 7586649; 9203065; 12393180; 10338095; 10839995; 10737981; 11511921

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5601

# Metabolic_Enzyme_5_Name:
Lactase-phlorizin hydrolase precursor

# Metabolic_Enzyme_5_Synonyms:
Lactase-glycosylceramidase[Includes: Lactase

# Metabolic_Enzyme_5_Gene_Name:
LCT

# Metabolic_Enzyme_5_Protein_Sequence:
>Lactasephlorizin hydrolase precursor
MELSWHVVFIALLSFSCWGSDWESDRNFISTAGPLTNDLLHNLSGLLGDQSSNFVAGDKD
MYVCHQPLPTFLPEYFSSLHASQITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKAL
KTARLQPMVILHHQTLPASTLRRTEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIK
ELPHQESRASQLQTLSDAHRKAYEIYHESYAFQGGKLSVVLRAEDIPELLLEPPISALAQ
DTVDFLSLDLSYECQNEASLRQKLSKLQTIEPKVKVFIFNLKLPDCPSTMKNPASLLFSL
FEAINKDQVLTIGFDINEFLSCSSSSKKSMSCSLTGSLALQPDQQQDHETTDSSPASAYQ
RVWEAFANQSRAERDAFLQDTFPEGFLWGASTGAFNVEGGWAEGGRGVSIWDPRRPLNTT
EGQATLEVASDSYHKVASDVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKL
IDRLQDAGIEPMATLFHWDLPQALQDHGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTF
HEPWVMSYAGYGTGQHPPGISDPGVASFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIV
LNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFVDGDYPATLRTQIQQMNRQCSHPV
AQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQHVNHVWPQT
SSSWIRVVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYIN
EVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTS
IIEKNGFLTKGAKRLLPPNTVNLPSKVRAFTFPSEVPSKAKVVWEKFSSQPKFERDLFYH
GTFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLD
ADLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFH
WDLPQALQDIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFP
PGVKDPGWAPYRIAHTVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDV
EAADRMLQFSLGWFAHPIFRNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRAT
ADVFCLNTYYSRIVQHKTPRLNPPSYEDDQEMAEEEDPSWPSTAMNRAAPWGTRRLLNWI
KEEYGDIPIYITENGVGLTNPNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWSLMD
NFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMPLAREDEFLYGRFPEG
FIWSAASAAYQIEGAWRADGKGLSIWDTFSHTPLRVENDAIGDVACDSYHKIAEDLVTLQ
NLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHWDLPQTL
QDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTAAPGVSNRP
GTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSNQEDVEAARRY
VQFMGGWFAHPIFKNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRINGTYDFFGF
NHYTTVLAYNLNYATAISSFDADRGVASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEY
NDPPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEW
ATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPDPATGPHACLHQPDAGPTI
SPVRQEEVQFLGLMLGTTEAQTALYVLFSLVLLGVCGLAFLSYKYCKRSKQGKTQRSQQE
LSPVSSF

# Metabolic_Enzyme_5_Number_of_Residues:
1927

# Metabolic_Enzyme_5_Molecular_Weight:
218604

# Metabolic_Enzyme_5_Theoretical_pI:
6.30

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  glucosidase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
LPH splits lactose in the small intestine

# Metabolic_Enzyme_5_Pathway:
map00052  Galactose metabolism

# Metabolic_Enzyme_5_Reaction:
lactose + H2O = D-galactose + D-glucose

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00232:Glyco_hydro_1

# Metabolic_Enzyme_5_Signals:
1-19

# Metabolic_Enzyme_5_Transmembrane_Regions:
1883-1901

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.2.1.108;EC 3.2.1.62

# Metabolic_Enzyme_5_GenBank_ID_Protein:
34400

# Metabolic_Enzyme_5_SwissProt_ID:
LPH_HUMAN (P09848)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
LCT

# Metabolic_Enzyme_5_Geneatlas_id:
LCT

# Metabolic_Enzyme_5_hgnc_id:
HGNC:6530

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cell membrane; apical cell membrane; single- pass type I membrane protein. Note=Brush border

# Metabolic_Enzyme_5_Gene_Sequence:
>5784 bp
ATGGAGCTGTCTTGGCATGTAGTCTTTATTGCCCTGCTAAGTTTTTCATGCTGGGGGTCA
GACTGGGAGTCTGATAGAAATTTCATTTCCACCGCTGGTCCTCTAACCAATGACTTGCTG
CACAACCTGAGTGGTCTCCTGGGAGACCAGAGTTCTAACTTTGTAGCAGGGGACAAAGAC
ATGTATGTTTGTCACCAGCCACTGCCCACTTTCCTGCCAGAATACTTCAGCAGTCTCCAT
GCCAGTCAGATCACCCATTATAAGGTATTTCTGTCATGGGCACAGCTCCTCCCAGCAGGA
AGCACCCAGAATCCAGACGAGAAAACAGTGCAGTGCTACCGGCGACTCCTCAAGGCCCTC
AAGACTGCACGGCTTCAGCCCATGGTCATCCTGCACCACCAGACCCTCCCTGCCAGCACC
CTCCGGAGAACCGAAGCCTTTGCTGACCTCTTCGCCGACTATGCCACATTCGCCTTCCAC
TCCTTCGGGGACCTAGTTGGGATCTGGTTCACCTTCAGTGACTTGGAGGAAGTGATCAAG
GAGCTTCCCCACCAGGAATCAAGAGCGTCACAACTCCAGACCCTCAGTGATGCCCACAGA
AAAGCCTATGAGATTTACCACGAAAGCTATGCTTTTCAGGGCGGAAAACTCTCTGTTGTC
CTGCGAGCTGAAGATATCCCGGAGCTCCTGCTAGAACCACCCATATCTGCGCTTGCCCAG
GACACGGTCGATTTCCTCTCTCTTGATTTGTCTTATGAATGCCAAAATGAGGCAAGTCTG
CGGCAGAAGCTGAGTAAATTGCAGACCATTGAGCCAAAAGTGAAAGTTTTCATCTTCAAC
CTAAAACTCCCAGACTGCCCCTCCACCATGAAGAACCCAGCCAGTCTGCTCTTCAGCCTT
TTTGAAGCCATAAATAAAGACCAAGTGCTCACCATTGGGTTTGATATTAATGAGTTTCTG
AGTTGTTCATCAAGTTCCAAGAAAAGCATGTCTTGTTCTCTGACTGGCAGCCTGGCCCTT
CAGCCTGACCAGCAGCAGGACCACGAGACCACGGACTCCTCTCCTGCCTCTGCCTATCAG
AGAGTCTGGGAAGCATTTGCCAATCAGTCCAGAGCGGAAAGGGATGCCTTCCTGCAGGAT
ACTTTCCCTGAAGGCTTCCTCTGGGGTGCCTCCACAGGAGCCTTTAACGTGGAAGGAGGC
TGGGCCGAGGGTGGGAGAGGGGTGAGCATCTGGGATCCACGCAGGCCCCTGAACACCACT
GAGGGCCAAGCGACGCTGGAGGTGGCCAGCGACAGTTACCACAAGGTAGCCTCTGACGTC
GCCCTGCTTTGCGGCCTCCGGGCTCAGGTGTACAAGTTCTCCATCTCCTGGTCCCGGATC
TTCCCCATGGGGCACGGGAGCAGCCCCAGCCTCCCAGGCGTTGCCTACTACAACAAGCTG
ATTGACAGGCTACAGGATGCGGGCATCGAGCCCATGGCCACGCTGTTCCACTGGGACCTG
CCTCAGGCCCTGCAGGATCATGGTGGATGGCAGAATGAGAGCGTGGTGGATGCCTTCCTG
GACTATGCGGCCTTCTGCTTCTCCACATTTGGGGACCGTGTGAAGCTGTGGGTGACCTTC
CATGAGCCGTGGGTGATGAGCTACGCAGGCTATGGCACCGGCCAGCACCCTCCCGGCATC
TCTGACCCAGGAGTGGCCTCTTTTAAGGTGGCTCACTTGGTCCTCAAGGCTCATGCCAGA
ACTTGGCACCACTACAACAGCCATCATCGCCCACAGCAGCAGGGGCACGTGGGCATTGTG
CTGAACTCAGACTGGGCAGAACCCCTGTCTCCAGAGAGGCCTGAGGACCTGAGAGCCTCT
GAGCGCTTCTTGCACTTCATGCTGGGCTGGTTTGCACACCCCGTCTTTGTGGATGGAGAC
TACCCAGCCACCCTGAGGACCCAGATCCAACAGATGAACAGACAGTGCTCCCATCCTGTG
GCTCAACTCCCCGAGTTCACAGAGGCAGAGAAGCAGCTCCTGAAAGGCTCTGCTGATTTT
CTGGGTCTGTCGCATTACACCTCCCGCCTCATCAGCAACGCCCCACAAAACACCTGCATC
CCTAGCTATGATACCATTGGAGGCTTCTCCCAACACGTGAACCATGTGTGGCCCCAGACC
TCATCCTCTTGGATTCGTGTGGTGCCCTGGGGGATAAGGAGGCTGTTGCAGTTTGTATCC
CTGGAATACACAAGAGGAAAAGTTCCAATATACCTTGCCGGGAATGGCATGCCCATAGGG
GAAAGTGAAAATCTCTTTGATGATTCCTTAAGAGTAGACTACTTCAATCAATATATCAAT
GAGGTGCTCAAGGCTATCAAGGAAGACTCTGTGGATGTTCGTTCCTACATTGCTCGTTCC
CTCATTGATGGCTTCGAAGGCCCTTCTGGTTACAGCCAGCGGTTTGGCCTGCACCACGTC
AACTTCAGCGACAGCAGCAAGTCAAGGACTCCCAGGAAATCTGCCTACTTTTTCACTAGC
ATCATAGAAAAGAACGGTTTCCTCACCAAGGGGGCAAAAAGACTGCTACCACCTAATACA
GTAAACCTCCCCTCCAAAGTCAGAGCCTTCACTTTTCCATCTGAGGTGCCCTCCAAGGCT
AAAGTCGTTTGGGAAAAGTTCTCCAGCCAACCCAAGTTCGAAAGAGATTTGTTCTACCAC
GGGACGTTTCGGGATGACTTTCTGTGGGGCGTGTCCTCTTCCGCTTATCAGATTGAAGGC
GCGTGGGATGCCGATGGCAAAGGCCCCAGCATCTGGGATAACTTTACCCACACACCAGGG
AGCAATGTGAAAGACAATGCCACTGGAGACATCGCCTGTGACAGCTATCACCAGCTGGAT
GCCGATCTGAATATGCTCCGAGCTTTGAAGGTGAAGGCCTACCGCTTCTCTATCTCCTGG
TCTCGGATTTTCCCAACTGGGAGAAACAGCTCTATCAACAGTCATGGGGTTGATTATTAC
AACAGGCTGATCAATGGCTTGGTGGCAAGCAACATCTTTCCCATGGTGACATTGTTCCAT
TGGGACCTGCCCCAGGCCCTCCAGGATATCGGAGGCTGGGAGAATCCTGCCTTGATTGAC
TTGTTTGACAGCTACGCAGACTTTTGTTTCCAGACCTTTGGTGATAGAGTCAAGTTTTGG
ATGACTTTTAATGAGCCCATGTACCTGGCATGGCTAGGTTATGGCTCAGGGGAATTTCCC
CCAGGGGTGAAGGACCCAGGCTGGGCACCATATAGGATAGCCCACACCGTCATCAAAGCC
CATGCCAGAGTCTATCACACGTACGATGAGAAATACAGGCAGGAGCAGAAGGGGGTCATC
TCGCTGAGCCTCAGTACACACTGGGCAGAGCCCAAGTCACCAGGGGTCCCCAGAGATGTG
GAAGCCGCTGACCGAATGCTGCAGTTCTCCCTGGGCTGGTTTGCTCACCCCATTTTTAGA
AACGGAGACTATCCTGACACCATGAAGTGGAAAGTGGGGAACAGGAGTGAACTGCAGCAC
TTAGCCACCTCCCGCCTGCCAAGCTTCACTGAGGAAGAGAAGAGGTTCATCAGGGCGACG
GCCGACGTCTTCTGCCTCAACACGTACTACTCCAGAATCGTGCAGCACAAAACACCCAGG
CTAAACCCACCCTCCTACGAAGACGACCAGGAGATGGCTGAGGAGGAGGACCCTTCGTGG
CCTTCCACGGCAATGAACAGAGCTGCGCCCTGGGGGACGCGAAGGCTGCTGAACTGGATC
AAGGAAGAGTATGGTGACATCCCCATTTACATCACCGAAAACGGAGTGGGGCTGACCAAT
CCGAACACGGAGGATACTGATAGGATATTTTACCACAAAACCTACATCAATGAGGCTTTG
AAAGCCTACAGGCTCGATGGTATAGACCTTCGAGGGTATGTCGCCTGGTCTCTGATGGAC
AACTTTGAGTGGCTAAATGGCTACACGGTCAAGTTTGGACTGTACCATGTTGATTTCAAC
AACACGAACAGGCCTCGCACAGCAAGAGCCTCCGCCAGGTACTACACAGAGGTCATTACC
AACAACGGCATGCCACTGGCCAGGGAGGATGAGTTTCTGTACGGACGGTTTCCTGAGGGC
TTCATCTGGAGTGCAGCTTCTGCTGCATATCAGATTGAAGGTGCGTGGAGAGCAGATGGC
AAAGGACTCAGCATTTGGGACACGTTTTCTCACACACCACTGAGGGTTGAGAACGATGCC
ATTGGAGACGTGGCCTGTGACAGTTATCACAAGATTGCTGAGGATCTGGTCACCCTGCAG
AACCTGGGTGTGTCCCACTACCGTTTTTCCATCTCCTGGTCTCGCATCCTCCCTGATGGA
ACCACCAGGTACATCAATGAAGCGGGCCTGAACTACTACGTGAGGCTCATCGATACACTG
CTGGCCGCCAGCATCCAGCCCCAGGTGACCATTTACCACTGGGACCTACCACAGACGCTC
CAAGATGTAGGAGGCTGGGAGAATGAGACCATCGTGCAGCGGTTTAAGGAGTATGCAGAT
GTGCTCTTCCAGAGGCTGGGAGACAAGGTGAAGTTTTGGATCACGTTGAATGAGCCCTTT
GTCATTGCTTACCAGGGCTATGGCTACGGAACAGCAGCTCCAGGAGTCTCCAATAGGCCT
GGCACTGCCCCCTACATTGTTGGCCACAATCTAATAAAGGCTCATGCTGAGGCCTGGCAT
CTGTACAACGATGTGTACCGCGCCAGTCAAGGTGGCGTGATTTCCATCACCATCAGCAGT
GACTGGGCTGAACCCAGAGATCCCTCTAACCAGGAGGATGTGGAGGCAGCCAGGAGATAT
GTTCAGTTCATGGGAGGCTGGTTTGCACATCCTATTTTCAAGAATGGAGATTACAATGAG
GTGATGAAGACGCGGATCCGTGACAGGAGCTTGGCTGCAGGCCTCAACAAGTCTCGGCTG
CCAGAATTTACAGAGAGTGAGAAGAGGAGGATCAACGGCACCTATGACTTTTTTGGGTTC
AATCACTACACCACTGTCCTCGCCTACAACCTCAACTATGCCACTGCCATCTCTTCTTTT
GATGCAGACAGAGGAGTTGCTTCCATCGCAGATCGCTCGTGGCCAGACTCTGGCTCCTTC
TGGCTGAAGATGACGCCTTTTGGCTTCAGGAGGATCCTGAACTGGTTAAAGGAGGAATAC
AATGACCCTCCAATTTATGTCACAGAGAATGGAGTGTCCCAGCGGGAAGAAACAGACCTC
AATGACACTGCAAGGATCTACTACCTTCGGACTTACATCAATGAGGCCCTCAAAGCTGTG
CAGGACAAGGTGGACCTTCGAGGATACACAGTTTGGAGTGCGATGGACAATTTTGAGTGG
GCCACAGGCTTTTCAGAGAGATTTGGTCTGCATTTTGTGAACTACAGTGACCCTTCTCTG
CCAAGGATCCCCAAAGCATCAGCGAAGTTCTACGCCTCTGTGGTCCGATGCAATGGCTTC
CCTGACCCCGCTACAGGGCCTCACGCTTGTCTCCACCAGCCAGATGCTGGACCCACCATC
AGCCCCGTGAGACAGGAGGAGGTGCAGTTCCTGGGGCTAATGCTCGGCACCACAGAAGCA
CAGACAGCTTTGTACGTTCTCTTTTCTCTTGTGCTTCTTGGAGTCTGTGGCTTGGCATTT
CTGTCATACAAGTACTGCAAGCGCTCTAAGCAAGGGAAAACACAACGAAGCCAACAGGAA
TTGAGCCCGGTGTCTTCATTCTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X07994

# Metabolic_Enzyme_5_Chromosome_Location:
Not Available

# Metabolic_Enzyme_5_Locus:
Not Available

# Metabolic_Enzyme_5_SNPs:
Not Available

# Metabolic_Enzyme_5_General_References:
2460343; 1902057

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
6155

# Metabolic_Enzyme_6_Name:
Beta-1,4 N-acetylgalactosaminyltransferase 1

# Metabolic_Enzyme_6_Synonyms:
(N- acetylneuraminyl-galactosylglucosylceramide; GM2/GD2 synthase; GalNAc-T

# Metabolic_Enzyme_6_Gene_Name:
B4GALNT1

# Metabolic_Enzyme_6_Protein_Sequence:
>Beta1,4 Nacetylgalactosaminyltransferase 1
MWLGRRALCALVLLLACASLGLLYASTRDAPGLRLPLAPWAPPQSPRRPELPDLAPEPRY
AHIPVRIKEQVVGLLAWNNCSCESSGGGLPLPFQKQVRAIDLTKAFDPAELRAASATREQ
EFQAFLSRSQSPADQLLIAPANSPLQYPLQGVEVQPLRSILVPGLSLQAASGQEVYQVNL
TASLGTWDVAGEVTGVTLTGEGQADLTLVSPGLDQLNRQLQLVTYSSRSYQTNTADTVRF
STEGHEAAFTIRIRHPPNPRLYPPGSLPQGAQYNISALVTIATKTFLRYDRLRALITSIR
RFYPTVTVVIADDSDKPERVSGPYVEHYLMPFGKGWFAGRNLAVSQVTTKYVLWVDDDFV
FTARTRLERLVDVLERTPLDLVGGAVREISGFATTYRQLLSVEPGAPGLGNCLRQRRGFH
HELVGFPGCVVTDGVVNFFLARTDKVREVGFDPRLSRVAHLEFFLDGLGSLRVGSCSDVV
VDHASKLKLPWTSRDAGAETYARYRYPGSLDESQMAKHRLLFFKHRLQCMTSQ

# Metabolic_Enzyme_6_Number_of_Residues:
533

# Metabolic_Enzyme_6_Molecular_Weight:
58883

# Metabolic_Enzyme_6_Theoretical_pI:
8.82

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  lipid modification
Process:  lipid glycosylation
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  intrinsic to organelle membrane
Component:  intrinsic to Golgi membrane
Component:  integral to Golgi membrane

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Involved in the biosynthesis of gangliosides GM2, GD2 and GA2

# Metabolic_Enzyme_6_Pathway:
map00604  Ganglioside biosynthesis

# Metabolic_Enzyme_6_Reaction:
UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00535:Glycos_transf_2

# Metabolic_Enzyme_6_Signals:
1-25

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.4.1.92

# Metabolic_Enzyme_6_GenBank_ID_Protein:
431033

# Metabolic_Enzyme_6_SwissProt_ID:
B4GN1_HUMAN (Q00973)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
B4GALNT1

# Metabolic_Enzyme_6_Geneatlas_id:
B4GALNT1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:4117

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_6_Gene_Sequence:
>1602 bp
ATGTGGCTGGGCCGCCGGGCCCTGTGCGCTCTGGTCCTTCTGCTCGCCTGCGCCTCGCTG
GGGCTCCTGTACGCGAGCACCCGGGACGCGCCCGGCCTCCGGCTACCTCTTGCGCCGTGG
GCGCCCCCGCAAAGCCCCCGCAGGCCCGAGCTGCCAGATCTTGCTCCTGAGCCCCGCTAC
GCACACATCCCGGTCAGGATCAAGGAGCAAGTAGTGGGGCTGCTGGCTTGGAACAACTGC
AGTTGTGAGTCCAGTGGGGGGGGCCTCCCCCTCCCCTTCCAGAAACAAGTCCGAGCTATT
GACCTCACCAAGGCCTTTGACCCTGCAGAGCTGAGGGCTGCCTCTGCCACAAGAGAGCAG
GAGTTCCAGGCCTTTCTGTCGAGGAGCCAGTCCCCAGCTGACCAGCTGCTCATAGCCCCT
GCCAACTCCCCGCTCCAGTACCCCCTACAGGGTGTGGAAGTTCAGCCCCTCAGGAGCATC
TTGGTGCCAGGGCTGAGCCTTCAGGCAGCTTCTGGTCAGGAGGTATACCAGGTGAACCTG
ACTGCCTCCCTAGGCACCTGGGACGTGGCAGGGGAAGTGACTGGAGTTACTCTCACTGGA
GAGGGTCAGGCAGATCTCACCCTTGTCAGCCCAGGGCTGGACCAACTCAACAGGCAACTA
CAACTGGTCACTTACAGCAGCCGAAGCTACCAGACCAACACAGCAGACACAGTCCGGTTC
TCCACCGAGGGACATGAGGCTGCTTTCACTATCCGCATAAGACACCCGCCCAACCCTCGG
CTGTACCCACCTGGGTCTCTACCCCAGGGAGCCCAGTACAACATCAGCGCTCTAGTCACG
ATTGCCACCAAGACCTTCCTCCGTTATGATCGGCTACGGGCTCTCATCACCAGTATCCGC
CGCTTCTACCCAACGGTTACCGTGGTCATCGCTGACGACAGCGACAAGCCAGAGCGCGTT
AGTGGCCCCTACGTGGAACACTATCTCATGCCCTTCGGCAAGGGCTGGTTCGCAGGCCGG
AACCTGGCCGTGTCTCAAGTAACCACCAAGTACGTGCTGTGGGTGGACGACGACTTCGTC
TTCACGGCGCGGACGCGGCTGGAGAGGCTTGTGGACGTGCTGGAGCGGACGCCGCTGGAC
CTGGTGGGGGGCGCGGTGCGCGAGATCTCCGGCTTTGCCACCACTTATCGGCAGCTGCTG
AGCGTGGAGCCCGGCGCCCCAGGCCTCGGGAACTGCCTCCGGCAAAGGCGCGGCTTCCAC
CACGAGCTCGTCGGCTTCCCAGGCTGCGTGGTCACCGACGGCGTGGTTAACTTCTTCCTG
GCGCGGACTGACAAGGTGCGCGAGGTCGGTTTCGACCCCCGCCTCAGCCGCGTGGCTCAT
CTGGAATTCTTCTTGGATGGGCTTGGTTCCCTTCGGGTTGGCTCCTGCTCCGACGTCGTG
GTGGATCATGCATCCAAACTGAAGCTGCCTTGGACATCAAGGGATGCCGGAGCAGAGACT
TACGCCCGGTACCGTTACCCAGGATCACTGGACGAGAGCCAGATGGCCAAACACCGGCTG
CTCTTCTTCAAACACCGGCTGCAGTGCATGACCTCCCAGTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M83651

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_6_Locus:
12q13.3

# Metabolic_Enzyme_6_SNPs:
rs774896; rs17454674; rs715930; rs11616065; rs774898; rs774897; rs2307094; rs2307095; rs2258877; rs10083154; rs703832; rs1382848; rs12322482; rs813516; rs12320537; rs715931; rs6581147; rs774899; rs2619468; rs3899676; rs12578587; rs4397894; rs810205; rs11558416; rs17852705; rs12811234; rs5798412; rs35469314; rs13353074; rs35389290; rs36076355; rs5798411; rs35506397; rs35287199; rs5798410; rs34425030; rs5798413; rs7979463; rs12811305; rs12296818; rs12296706; rs7953934; rs35612896; rs7953917; rs7979462; rs34271193; rs1027315; rs1038914; rs1064308; rs11172270; rs11613457; rs14561; rs1552842; rs1564374; rs1564375; rs1871417; rs2169987; rs2277324; rs2619470; rs2640607; rs35831868; rs3741418; rs3886856; rs4617628; rs4760309; rs5026124; rs7294447; rs7314152; rs774893; rs774894; rs774895; rs903067; rs923828; rs971209

# Metabolic_Enzyme_6_General_References:
1601877; 8120069; 11018043

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5559

# Metabolic_Enzyme_7_Name:
Sialidase-1 precursor

# Metabolic_Enzyme_7_Synonyms:
Lysosomal sialidase; N-acetyl- alpha-neuraminidase 1; Acetylneuraminyl hydrolase; G9 sialidase

# Metabolic_Enzyme_7_Gene_Name:
NEU1

# Metabolic_Enzyme_7_Protein_Sequence:
>Sialidase1 precursor
MTGERPSTALPDRRWGPRILGFWGGCRVWVFAAIFLLLSLAASWSKAENDFGLVQPLVTM
EQLLWVSGRQIGSVDTFRIPLITATPRGTLLAFAEARKMSSSDEGAKFIALRRSMDQGST
WSPTAFIVNDGDVPDGLNLGAVVSDVETGVVFLFYSLCAHKAGCQVASTMLVWSKDDGVS
WSTPRNLSLDIGTEVFAPGPGSGIQKQREPRKGRLIVCGHGTLERDGVFCLLSDDHGASW
RYGSGVSGIPYGQPKQENDFNPDECQPYELPDGSVVINARNQNNYHCHCRIVLRSYDACD
TLRPRDVTFDPELVDPVVAAGAVVTSSGIVFFSNPAHPEFRVNLTLRWSFSNGTSWRKET
VQLWPGPSGYSSLATLEGSMDGEEQAPQLYVLYEKGRNHYTESISVAKISVYGTL

# Metabolic_Enzyme_7_Number_of_Residues:
415

# Metabolic_Enzyme_7_Molecular_Weight:
45468

# Metabolic_Enzyme_7_Theoretical_pI:
5.68

# Metabolic_Enzyme_7_GO_Classification:
Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Catalyzes the removal of sialic acid (N-acetylneuramic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage

# Metabolic_Enzyme_7_Pathway:
map00511  N-Glycan degradation;
 map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_7_Reaction:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF02012:BNR

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
20-42

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.2.1.18

# Metabolic_Enzyme_7_GenBank_ID_Protein:
2773339

# Metabolic_Enzyme_7_SwissProt_ID:
NEUR1_HUMAN (Q99519)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
NEU1

# Metabolic_Enzyme_7_Geneatlas_id:
NEU1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:7758

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Lysosome; lysosomal membrane; peripheral membrane protein; lumenal side. Lysosome; lysosomal lumen. Cell membrane. Cytoplasmic vesicle. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles

# Metabolic_Enzyme_7_Gene_Sequence:
>1248 bp
ATGACTGGGGAGCGACCCAGCACGGCGCTCCCGGACAGACGCTGGGGGCCGCGGATTCTG
GGCTTCTGGGGAGGCTGTAGGGTTTGGGTGTTTGCCGCGATCTTCCTGCTGCTGTCTCTG
GCAGCCTCCTGGTCCAAGGCTGAGAACGACTTCGGTCTGGTGCAGCCGCTGGTGACCATG
GAGCAACTGCTGTGGGTGAGCGGGAGACAGATCGGCTCAGTGGACACCTTCCGCATCCCG
CTCATCACAGCCACTCCGCGGGGCACTCTTCTCGCCTTTGCTGAGGCGAGGAAAATGTCC
TCATCCGATGAGGGGGCCAAGTTCATCGCCCTGCGGAGGTCCATGGACCAGGGCAGCACA
TGGTCTCCTACAGCGTTCATTGTCAATGATGGGGATGTCCCCGATGGGCTGAACCTTGGG
GCAGTAGTGAGCGATGTTGAGACAGGAGTAGTATTTCTTTTCTACTCCCTTTGTGCTCAC
AAGGCCGGCTGCCAGGTGGCCTCTACCATGTTGGTATGGAGCAAGGATGATGGTGTTTCC
TGGAGCACACCCCGGAATCTCTCCCTGGATATTGGCACTGAAGTGTTTGCCCCTGGACCG
GGCTCTGGTATTCAGAAACAGCGGGAGCCACGGAAGGGCCGCCTCATCGTGTGTGGCCAT
GGGACGCTGGAGCGGGACGGAGTCTTCTGTCTCCTCAGCGATGATCATGGTGCCTCCTGG
CGCTACGGAAGTGGGGTCAGCGGCATCCCCTACGGTCAGCCCAAGCAGGAAAATGATTTC
AATCCTGATGAATGCCAGCCCTATGAGCTCCCAGATGGCTCAGTCGTCATCAATGCCCGA
AACCAGAACAACTACCACTGCCACTGCCGAATTGTCCTCCGCAGCTATGATGCCTGTGAT
ACACTAAGGCCCCGTGATGTGACCTTCGACCCTGAGCTCGTGGACCCTGTGGTAGCTGCA
GGAGCTGTAGTCACCAGCTCCGGCATTGTCTTCTTCTCCAACCCAGCACATCCAGAGTTC
CGAGTGAACCTGACCCTGCGATGGAGCTTCAGCAATGGTACCTCATGGCGGAAAGAGACA
GTCCAGCTATGGCCAGGCCCCAGTGGCTATTCATCCCTGGCAACCCTGGAGGGCAGCATG
GATGGAGAGGAGCAGGCCCCCCAGCTCTACGTCCTGTATGAGAAAGGCCGGAACCACTAC
ACAGAGAGCATCTCCGTGGCCAAAATCAGTGTCTATGGGACACTCTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AF040958

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_7_Locus:
6p21.3

# Metabolic_Enzyme_7_SNPs:
Not Available

# Metabolic_Enzyme_7_General_References:
8985184; 9020182; 9054950; 9480870; 10767332; 11063730; 10944856; 11279074

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5558

# Metabolic_Enzyme_8_Name:
Sialidase-4

# Metabolic_Enzyme_8_Synonyms:
N-acetyl-alpha-neuraminidase 4

# Metabolic_Enzyme_8_Gene_Name:
NEU4

# Metabolic_Enzyme_8_Protein_Sequence:
>Sialidase4
MGVPRTPSRTVLFERERTGLTYRVPSLLPVPPGPTLLAFVEQRLSPDDSHAHRLVLRRGT
LAGGSVRWGALHVLGTAALAEHRSMNPCPVHDAGTGTVFLFFIAVLGHTPEAVQIATGRN
AARLCCVASRDAGLSWGSARDLTEEAIGGAVQDWATFAVGPGHGVQLPSGRLLVPAYTYR
VDRRECFGKICRTSPHSFAFYSDDHGRTWRCGGLVPNLRSGECQLAAVDGGQAGSFLYCN
ARSPLGSRVQALSTDEGTSFLPAERVASLPETAWGCQGSIVGFPAPAPNRPRDDSWSVGP
GSPLQPPLLGPGVHEPPEEAAVDPRGGQVPGGPFSRLQPRGDGPRQPGPRPGVSGDVGSW
TLALPMPFAAPPQSPTWLLYSHPVGRRARLHMGIRLSQSPLDPRSWTEPWVIYEGPSGYS
DLASIGPAPEGGLVFACLYESGARTSYDEISFCTFSLREVLENVPASPKPPNLGDKPRGC
CWPS

# Metabolic_Enzyme_8_Number_of_Residues:
484

# Metabolic_Enzyme_8_Molecular_Weight:
51573

# Metabolic_Enzyme_8_Theoretical_pI:
7.84

# Metabolic_Enzyme_8_GO_Classification:
Not Available

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc)

# Metabolic_Enzyme_8_Pathway:
map00511  N-Glycan degradation;
 map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_8_Reaction:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates

# Metabolic_Enzyme_8_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.2.1.18

# Metabolic_Enzyme_8_GenBank_ID_Protein:
18073364

# Metabolic_Enzyme_8_SwissProt_ID:
NEUR4_HUMAN (Q8WWR8)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
NEU4

# Metabolic_Enzyme_8_Geneatlas_id:
NEU4

# Metabolic_Enzyme_8_hgnc_id:
HGNC:21328

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Membrane; peripheral membrane protein

# Metabolic_Enzyme_8_Gene_Sequence:
>1455 bp
ATGGGGGTCCCTCGTACCCCTTCACGGACAGTGCTCTTCGAGCGGGAGAGGACGGGCCTG
ACCTACCGCGTGCCCTCGCTGCTCCCCGTGCCCCCCGGGCCCACCCTGCTGGCCTTTGTG
GAGCAGCGGCTCAGCCCTGACGACTCCCACGCCCACCGCCTGGTGCTGAGGAGGGGCACG
CTGGCCGGGGGCTCCGTGCGGTGGGGTGCCCTGCACGTGCTGGGGACAGCAGCCCTGGCG
GAGCACCGGTCCATGAACCCCTGCCCTGTGCACGATGCTGGCACGGGCACCGTCTTCCTC
TTCTTCATCGCGGTGCTGGGCCACACGCCTGAGGCCGTGCAGATCGCCACGGGAAGGAAC
GCCGCGCGCCTCTGCTGTGTGGCCAGCCGTGACGCCGGCCTCTCGTGGGGCAGCGCCCGG
GACCTCACCGAGGAGGCCATCGGTGGTGCCGTGCAGGACTGGGCCACATTCGCTGTGGGT
CCCGGCCACGGCGTGCAGCTGCCCTCAGGCCGCCTGCTGGTACCCGCCTACACCTACCGC
GTGGACCGCCTAGAGTGTTTTGGCAAGATCTGCCGGACCAGCCCTCACTCCTTCGCCTTC
TACAGCGATGACCACGGCCGCACCTGGCGCTGTGGAGGCCTCGTGCCCAACCTGCGCTCA
GGCGAGTGCCAGCTGGCGGCGGTGGACGGTGGGCAGGCCGGCAGCTTCCTCTACTGCAAT
GCCCGGAGCCCACTGGGCAGCCGTGTGCAGGCGCTCAGCACTGACGAGGGCACCTCCTTC
CTGCCCGCAGAGCGCGTGGCTTCCCTGCCCGAGACTGCCTGGGGCTGCCAGGGCAGCATC
GTGGGCTTCCCAGCCCCCGCCCCCAACAGGCCACGGGATGACAGTTGGTCAGTGGGCCCC
AGGAGTCCCCTCCAGCCTCCACTCCTCGGTCCTGGAGTCCACGAACCCCCAGAGGAGGCT
GCTGTAGACCCCCGTGGAGGCCAGGTGCCTGGTGGGCCCTTCAGCCGTCTGCAGCCTCGG
GGGGATGGCCCCAGGCAGCCTGGCCCCAGGCCTGGGGTCAGTGGGGATGTGGGGTCCTGG
ACCCTGGCACTCCCCATGCCCTTTGCTGCCCCGCCCCAGAGCCCCACGTGGCTGCTGTAC
TCCCACCCAGTGGGGCGCAGGGCTCGGCTACACATGGGTATCCGCCTGAGCCAGTCCCCG
CTGGACCCGCGCAGCTGGACAGAGCCCTGGGTGATCTACGAGGGCCCCAGCGGCTACTCC
GACCTGGCGTCCATCGGGCCGGCTCCTGAGGGGGGCCTGGTTTTTGCCTGCCTGTACGAG
AGCGGGGCCAGGACCTCCTATGATGAGATTTCCTTTTGTACATTCTCCCTGCGTGAGGTC
CTGGAGAACGTGCCCGCCAGCCCCAAGCCGCCCAACCTTGGGGACAAGCCTCGGGGGTGC
TGCTGGCCCTCCTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
AJ277883

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_8_Locus:
2q37.3

# Metabolic_Enzyme_8_SNPs:
rs2293761; rs2293763; rs2293764; rs3749158; rs3749157; rs2293759; rs6716431; rs760133; rs3749154; rs3749153; rs7577590; rs3749152; rs16747; rs6721711; rs13415837; rs2293762; rs11545301; rs36111671; rs2293760; rs35670872; rs3749156; rs35080591; rs11272205; rs11418387; rs13001802; rs4675992; rs34241734; rs35675008; rs28673516; rs34761249; rs34978277; rs11693567; rs4369896; rs11418388; rs34954858; rs28599541; rs2894717; rs2396770; rs3749155; rs13001775; rs10598812; rs34334067; rs35921906; rs35449025; rs35005220; rs34041588; rs35214534; rs34761692; rs741776

# Metabolic_Enzyme_8_General_References:
Not Available

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
6156

# Metabolic_Enzyme_9_Name:
Lactosylceramide 4-alpha-galactosyltransferase

# Metabolic_Enzyme_9_Synonyms:
Alpha- 1,4-galactosyltransferase; UDP-galactose:beta-D-galactosyl-beta1-R 4- alpha-D-galactosyltransferase; Alpha-1,4-N- acetylglucosaminyltransferase; Alpha4Gal-T1; Globotriaosylceramide synthase; Gb3 synthase; CD77 synthase; P1/Pk synthase

# Metabolic_Enzyme_9_Gene_Name:
A4GALT

# Metabolic_Enzyme_9_Protein_Sequence:
>Lactosylceramide 4alphagalactosyltransferase
MSKPPDLLLRLLRGAPRQRVCTLFIIGFKFTFFVSIMIYWHVVGEPKEKGQLYNLPAEIP
CPTLTPPTPPSHGPTPGNIFFLETSDRTNPNFLFMCSVESAARTHPESHVLVLMKGLPGG
NASLPRHLGISLLSCFPNVQMLPLDLRELFRDTPLADWYAAVQGRWEPYLLPVLSDASRI
ALMWKFGGIYLDTDFIVLKNLRNLTNVLGTQSRYVLNGAFLAFERRHEFMALCMRDFVDH
YNGWIWGHQGPQLLTRVFKKWCSIRSLAESRACRGVTTLPPEAFYPIPWQDWKKYFEDIN
PEELPRLLSATYAVHVWNKKSQGTRFEATSRALLAQLHARYCPTTHEAMKMYL

# Metabolic_Enzyme_9_Number_of_Residues:
353

# Metabolic_Enzyme_9_Molecular_Weight:
40500

# Metabolic_Enzyme_9_Theoretical_pI:
9.18

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
Function:  galactosyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  Golgi apparatus
Component:  Golgi stack

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins

# Metabolic_Enzyme_9_Pathway:
map00603  Globoside metabolism

# Metabolic_Enzyme_9_Reaction:
UDP-galactose + beta-D-galactosyl-(1->4)-D-glucosylceramide = UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D-glucosylceramide

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF04572:Gb3_synth;
PF04488:Gly_transf_sug

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
23-43

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.4.1.228

# Metabolic_Enzyme_9_GenBank_ID_Protein:
7959011

# Metabolic_Enzyme_9_SwissProt_ID:
A4GAT_HUMAN (Q9NPC4)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
A4GALT

# Metabolic_Enzyme_9_Geneatlas_id:
A4GALT

# Metabolic_Enzyme_9_hgnc_id:
HGNC:18149

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Probable)

# Metabolic_Enzyme_9_Gene_Sequence:
>1062 bp
ATGTCCAAGCCCCCCGACCTCCTGCTGCGGCTGCTCCGGGGCGCCCCAAGGCAGCGGGTC
TGCACCCTGTTCATCATCGGCTTCAAGTTCACGTTTTTCGTCTCCATCATGATCTACTGG
CACGTTGTGGGAGAGCCCAAGGAGAAAGGGCAGCTCTATAACCTGCCAGCAGAGATCCCC
TGCCCCACCTTGACACCCCCCACCCCACCCTCCCACGGCCCCACTCCAGGCAACATCTTC
TTCCTGGAGACTTCAGACCGGACCAACCCCAACTTCCTGTTCATGTGCTCGGTGGAGTCG
GCCGCCAGAACTCACCCCGAATCCCACGTGCTGGTCCTGATGAAAGGGCTTCCGGGTGGC
AACGCCTCTCTGCCCCGGCACCTGGGCATCTCACTTCTGAGCTGCTTCCCGAATGTCCAG
ATGCTCCCGCTGGACCTGCGGGAGCTGTTCCGGGACACACCCCTGGCCGACTGGTACGCG
GCCGTGCAGGGGCGCTGGGAGCCCTACCTGCTGCCCGTGCTCTCCGACGCCTCCAGGATC
GCACTCATGTGGAAGTTCGGCGGCATCTACCTGGACACGGACTTCATTGTTCTCAAGAAC
CTGCGGAACCTGACCAACGTGCTGGGCACCCAGTCCCGCTACGTCCTCAACGGCGCGTTC
CTGGCCTTCGAGCGCCGGCACGAGTTCATGGCGCTGTGCATGCGGGACTTCGTGGACCAC
TACAACGGCTGGATCTGGGGTCACCAGGGCCCGCAGCTGCTCACGCGGGTCTTCAAGAAG
TGGTGTTCCATCCGCAGCCTGGCCGAGAGCCGCGCCTGCCGCGGCGTCACCACCCTGCCC
CCTGAGGCCTTCTACCCCATCCCCTGGCAGGACTGGAAGAAGTACTTTGAGGACATCAAC
CCGGAGGAGCTGCCGCGGCTGCTCAGTGCCACCTATGCTGTCCACGTGTGGAACAAGAAG
AGCCAGGGCACGCGGTTCGAGGCCACGTCCAGGGCACTGCTGGCCCAGCTGCATGCCCGC
TACTGCCCCACGACGCACGAGGCCATGAAAATGTACTTGTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AB037883

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_9_Locus:
22q11.2-q13.2

# Metabolic_Enzyme_9_SNPs:
rs28915383; rs11541159; rs6002904; rs28915384; rs9623659; rs28915381; rs910303; rs2024643; rs7284681; rs910302; rs5758875; rs5758872; rs12628541; rs6002913; rs738526; rs6002910; rs1883991; rs5758870; rs5751343; rs8136914; rs5758881; rs738527; rs9623672; rs9620083; rs5758873; rs3788594; rs13057708; rs5996224; rs9623660; rs5758888; rs4820476; rs910301; rs130399; rs5758895; rs12170422; rs9611843; rs2143919; rs5758886; rs11090115; rs2143920; rs6002925; rs5751342; rs135108; rs9623671; rs3216827; rs5751340; rs7287297; rs3761465; rs12167417; rs5996227; rs8141906; rs13055547; rs5751345; rs135106; rs17485718; rs5758894; rs5758891; rs130394; rs6002927; rs3761462; rs3761467; rs130397; rs2143918; rs1883990; rs1053026; rs4822185; rs8138197; rs130396; rs5751347; rs11703455; rs5758897; rs5758871; rs8141536; rs5751341; rs6002914; rs3747194; rs3788595; rs3833392; rs5751348; rs12169036; rs7285550; rs28992178; rs12159739; rs5996225; rs28992183; rs28916570; rs28915371; rs11704081; rs6002908; rs8138149; rs28915387; rs28992169; rs9611845; rs130393; rs13056962; rs6002907; rs8138577; rs9620087; rs3747193; rs5758883; rs7287036; rs8139674; rs5758896; rs28992184; rs11704145; rs6002912; rs28915376; rs8141448; rs11704086; rs28992175; rs7287103; rs28915369; rs17003252; rs4822187; rs28992186; rs916231; rs28992177; rs7286918; rs130398; rs4822186; rs9620088; rs5758889; rs28992179; rs28915372; rs28992180; rs28992181; rs8141461; rs6002924; rs8139858; rs3761464; rs28992196; rs28992187; rs12484225; rs6002926; rs7364250; rs135107; rs11704052; rs130395; rs12170428; rs5758884; rs28992176; rs5758880; rs28992170; rs130392; rs10713068; rs5758890; rs28916568; rs13055886; rs28916569; rs1989502; rs7286195; rs7286214; rs28992193; rs28915388; rs17485489; rs9620086; rs5996226; rs28915390; rs28640172; rs28908470; rs5758885; rs28908469; rs28908471; rs5758893; rs6002915; rs8142445; rs739025; rs5751351; rs4822184; rs8184980; rs5758898; rs5758866; rs8142375; rs9607929; rs5751350; rs5845556; rs5996223; rs12168190; rs28915393; rs28910284; rs28915392; rs28910285; rs28915391; rs28910286; rs28915394; rs6002899; rs10544369; rs28940571; rs28940572; rs9611842; rs28915382; rs13058256; rs13057640; rs13055227; rs28992168; rs11703113; rs1989501; rs7286859; rs28915374; rs9607928; rs28915368; rs13056472; rs5758892; rs34555798; rs28915370; rs28915386; rs35971224; rs12167293; rs5758879; rs10656519; rs28915377; rs11703056; rs34555335; rs28992191; rs35353035; rs6002905; rs28992194; rs28915380; rs28992182; rs34090792; rs12157843; rs9623663; rs6002916; rs28992195; rs6002921; rs6002919; rs5758876; rs13056480; rs28915385; rs34144703; rs36007921; rs35400976; rs28992190; rs34765506; rs11420129; rs34661720; rs36026396; rs12168573; rs28992171; rs11409393; rs28992188; rs9620089; rs28915389; rs5751349; rs13055019; rs6002903; rs34424661; rs13055539; rs28558176; rs12628919; rs35303887; rs6002917; rs28992185; rs13056237; rs28992192; rs13056479; rs12166522; rs9611844; rs13056584; rs28915378; rs5758887; rs34470970; rs5845554; rs9623661; rs35648227; rs7288569; rs28992189; rs13056559; rs34155225; rs35107827; rs3985930; rs34531547; rs6002920; rs11327175; rs6002922; rs13056318; rs6002911; rs6002918; rs11400800; rs28915375; rs34471127; rs12160454; rs34095987; rs12159149; rs12166698; rs9611846; rs5758868; rs8135158; rs35650170; rs28915379; rs11388126; rs9623668; rs41277501; rs6002900; rs10694352; rs28915395; rs9607930; rs36060541; rs6002902; rs11469034; rs35727039; rs11370826; rs9611849; rs11703795; rs9611847; rs34860488; rs35079662; rs9611850; rs28910283; rs11469035; rs10610551; rs2899361; rs879257; rs6002901; rs9611848; rs12159495; rs12166331; rs12628410; rs130365; rs130370; rs130371; rs130372; rs130374; rs130384; rs130385; rs130386; rs130387; rs130388; rs130389; rs135096; rs135097; rs135098; rs135100; rs135103; rs17003212; rs34091628; rs4421; rs4822189; rs732336; rs736013; rs736014; rs736015; rs739024; rs9607931; rs9611852

# Metabolic_Enzyme_9_General_References:
10748143; 10747952; 10591208

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5552

# Metabolic_Enzyme_10_Name:
Sialidase-2

# Metabolic_Enzyme_10_Synonyms:
Cytosolic sialidase; N-acetyl-alpha- neuraminidase 2

# Metabolic_Enzyme_10_Gene_Name:
NEU2

# Metabolic_Enzyme_10_Protein_Sequence:
>Sialidase2
MASLPVLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASKKDEHAELIVLRRGDYD
APTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFFIAIPGQVTEQQQLQTRAN
VTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLNDRARSLVVPAYA
YRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVETGEQRVVTLNARSHL
RARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSVISFPSPRSGPGSPAQWLLYTHPTH
SWQRADLGAYLNPRPPAPEAWSEPVLLAKGSCAYSDLQSMGTGPDGSPLFGCLYEANDYE
EIVFLMFTLKQAFPAEYLPQ

# Metabolic_Enzyme_10_Number_of_Residues:
380

# Metabolic_Enzyme_10_Molecular_Weight:
42231

# Metabolic_Enzyme_10_Theoretical_pI:
6.83

# Metabolic_Enzyme_10_GO_Classification:
Not Available

# Metabolic_Enzyme_10_General_Function:
Not Available

# Metabolic_Enzyme_10_Specific_Function:
Hydrolyzes sialylated compounds

# Metabolic_Enzyme_10_Pathway:
map00511  N-Glycan degradation;
 map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_10_Reaction:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF02012:BNR

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 3.2.1.18

# Metabolic_Enzyme_10_GenBank_ID_Protein:
4688894

# Metabolic_Enzyme_10_SwissProt_ID:
NEUR2_HUMAN (Q9Y3R4)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
NEU2

# Metabolic_Enzyme_10_Geneatlas_id:
NEU2

# Metabolic_Enzyme_10_hgnc_id:
HGNC:7759

# Metabolic_Enzyme_10_PDB_ID:
1VCU

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_10_Gene_Sequence:
>1143 bp
ATGGCGTCCCTTCCTGTCCTGCAGAAGGAGAGCGTGTTCCAGTCGGGAGCCCATGCCTAC
AGAATCCCTGCCCTGCTCTACCTGCCTGGGCAGCAGTCCCTGCTGGCCTTCGCGGAACAG
CGGGCAAGCAAGAAGGATGAGCACGCAGAGCTGATTGTCCTGCGCAGAGGAGACTACGAC
GCACCCACCCACCAGGTTCAGTGGCAAGCTCAGGAGGTGGTGGCCCAGGCCCGGCTGGAT
GGCCACCGGTCCATGAACCCATGCCCCTTGTATGACGCGCAGACGGGGACCCTCTTCCTC
TTCTTCATTGCCATCCCTGGGCAAGTCACGGAGCAACAGCAGCTGCAGACCAGGGCCAAT
GTGACGCGGCTGTGCCAAGTCACCAGCACTGACCACGGGAGGACCTGGAGCTCCCCCAGA
GACCTCACTGATGCGGCCATCGGCCCAGCCTACCGGGAGTGGTCCACCTTTGCAGTGGGC
CCGGGGCATTGTTTGCAGCTTAACGACAGGGCCCGGAGCCTGGTGGTGCCCGCCTACGCC
TACCGGAAACTTCACCCCATCCAAAGGCCGATCCCCTCTGCCTTCTGCTTCCTCAGCCAT
GACCATGGGCGCACGTGGGCGCGAGGGCACTTTGTGGCCCAGGACACCCTGGAGTGCCAG
GTGGCCGAAGTCGAGACTGGGGAGCAGAGGGTGGTGACCCTCAACGCGAGAAGCCACCTC
CGAGCCAGGGTCCAGGCCCAGAGCACCAATGACGGGCTTGATTTCCAGGAGTCTCAGCTG
GTGAAGAAGCTGGTGGAGCCGCCGCCCCAGGGCTGCCAGGGGAGCGTCATCAGCTTCCCC
AGCCCCCGCTCGGGGCCTGGCTCCCCAGCCCAGTGGCTGCTCTACACTCACCCCACACAC
TCCTGGCAGAGGGCCGACCTGGGTGCCTACCTCAACCCGCGACCTCCAGCCCCTGAGGCC
TGGTCAGAGCCGGTACTGCTGGCCAAGGGCAGCTGTGCCTACTCAGACCTCCAGAGCATG
GGCACCGGCCCTGATGGGTCCCCCTTGTTTGGGTGTCTGTACGAAGCCAATGATTACGAG
GAGATTGTCTTTCTCATGTTCACCCTGAAGCAAGCCTTCCCAGCTGAGTACCTGCCTCAG
TGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
Y16535

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_10_Locus:
2q37

# Metabolic_Enzyme_10_SNPs:
rs2233384; rs2233385; rs2233391; rs2233394; rs2233395; rs2233388; rs2233392; rs11683026; rs11681712; rs11692562; rs2233381; rs11695991; rs2233375; rs4511711; rs2233382; rs2233390; rs2233393; rs2233389; rs2233386; rs2233387; rs35601609; rs3754578; rs12466655; rs2233376; rs3754577; rs2233378; rs34662352; rs34491352; rs2233383; rs2233377; rs2233396; rs2233379; rs2233380; rs12474626; rs10190420; rs11674444; rs11683765; rs13386477; rs13391656; rs1400349; rs34779565; rs4468801; rs4973594; rs6437086; rs6728702; rs6739218; rs7423054; rs869880; rs938568; rs9653384

# Metabolic_Enzyme_10_General_References:
10191093

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5555

# Metabolic_Enzyme_11_Name:
Sialidase-3

# Metabolic_Enzyme_11_Synonyms:
Membrane sialidase; Ganglioside sialidase; N-acetyl-alpha-neuraminidase 3

# Metabolic_Enzyme_11_Gene_Name:
NEU3

# Metabolic_Enzyme_11_Protein_Sequence:
>Sialidase3
MEEVTTCSFNSPLFRQEDDRGITYRIPALLYIPPTHTFLAFAEKRSTRRDEDALHLVLRR
GLRIGQLVQWGPLKPLMEATLPGHRTMNPCPVWEQKSGCVFLFFICVRGHVTERQQIVSG
RNAARLCFIYSQDAGCSWSEVRDLTEEVIGSELKHWATFAVGPGHGIQLQSGRLVIPAYT
YYIPSWFFCFQLPCKTRPHSLMIYSDDLGVTWHHGRLIRPMVTVECEVAEVTGRAGHPVL
YCSARTPNRCRAEALSTDHGEGFQRLALSRQLCEPPHGCQGSVVSFRPLEIPHRCQDSSS
KDAPTIQQSSPGSSLRLEEEAGTPSESWLLYSHPTSRKQRVDLGIYLNQTPLEAACWSRP
WILHCGPCGYSDLAALEEEGLFGCLFECGTKQECEQIAFRLFTHREILSHLQGDCTSPGR
NPSQFKSN

# Metabolic_Enzyme_11_Number_of_Residues:
428

# Metabolic_Enzyme_11_Molecular_Weight:
48252

# Metabolic_Enzyme_11_Theoretical_pI:
7.17

# Metabolic_Enzyme_11_GO_Classification:
Not Available

# Metabolic_Enzyme_11_General_Function:
Not Available

# Metabolic_Enzyme_11_Specific_Function:
Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates

# Metabolic_Enzyme_11_Pathway:
map00511  N-Glycan degradation;
 map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_11_Reaction:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF02012:BNR

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 3.2.1.18

# Metabolic_Enzyme_11_GenBank_ID_Protein:
5631293

# Metabolic_Enzyme_11_SwissProt_ID:
NEUR3_HUMAN (Q9UQ49)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
NEU3

# Metabolic_Enzyme_11_Geneatlas_id:
NEU3

# Metabolic_Enzyme_11_hgnc_id:
HGNC:7760

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Membrane; peripheral membrane protein

# Metabolic_Enzyme_11_Gene_Sequence:
>1287 bp
ATGGAAGAAGTGACAACATGCTCCTTCAACAGCCCTCTGTTCCGGCAGGAAGATGACAGA
GGGATTACCTACCGGATCCCAGCCCTGCTCTACATACCCCCCACCCACACCTTCCTGGCC
TTTGCAGAGAAGCGTTCCACGAGGAGAGATGAGGATGCTCTCCACCTGGTGCTGAGGCGA
GGGTTGAGGATTGGGCAGTTGGTACAGTGGGGGCCCCTGAAGCCACTGATGGAAGCCACA
CTACCGGGGCATCGGACCATGAACCCCTGTCCTGTATGGGAGCAGAAGAGTGGTTGTGTG
TTCCTGTTCTTCATCTGTGTGCGGGGCCATGTCACAGAGCGTCAACAGATTGTGTCAGGC
AGGAATGCTGCCCGCCTTTGCTTCATCTACAGTCAGGATGCTGGATGTTCATGGAGTGAG
GTGAGGGACTTGACTGAGGAGGTCATTGGCTCAGAGCTGAAGCACTGGGCCACATTTGCT
GTGGGCCCAGGTCATGGCATCCAGCTGCAGTCAGGGAGACTGGTCATCCCTGCGTATACC
TACTACATCCCTTCCTGGTTCTTTTGCTTCCAGCTACCATGTAAAACCAGGCCTCATTCT
CTGATGATCTACAGTGATGACCTAGGGGTCACATGGCACCATGGTAGACTCATTAGGCCC
ATGGTTACAGTAGAATGTGAAGTGGCAGAGGTGACTGGGAGGGCTGGCCACCCTGTGCTA
TATTGCAGTGCCCGGACACCAAACAGGTGCCGGGCAGAGGCGCTCAGCACTGACCATGGT
GAAGGCTTTCAGAGACTGGCCCTGAGTCGACAGCTCTGTGAGCCCCCACATGGTTGCCAA
GGGAGTGTGGTAAGTTTCCGGCCCCTGGAGATCCCACATAGGTGCCAGGACTCTAGCAGC
AAAGATGCACCCACCATTCAGCAGAGCTCTCCAGGCAGTTCACTGAGGCTGGAGGAGGAA
GCTGGAACACCGTCAGAATCATGGCTCTTGTACTCACACCCAACCAGTAGGAAACAGAGG
GTTGACCTAGGTATCTATCTCAACCAGACCCCCTTGGAGGCTGCCTGCTGGTCCCGCCCC
TGGATCTTGCACTGTGGGCCCTGTGGCTACTCTGATCTGGCTGCTCTGGAGGAGGAGGGC
TTGTTTGGGTGTTTGTTTGAATGTGGGACCAAGCAAGAGTGTGAGCAGATTGCCTTCCGC
CTGTTTACACACCGGGAGATCCTGAGTCACCTGCAGGGGGACTGCACCAGCCCTGGTAGG
AACCCAAGCCAATTCAAAAGCAATTAA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
AB008185

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_11_Locus:
11q13.5

# Metabolic_Enzyme_11_SNPs:
rs997465; rs3837410; rs7479000; rs536412; rs544115; rs10899053; rs7113716; rs11603294; rs578090; rs7115499; rs11236281; rs681566; rs494474; rs7931506; rs17245026; rs2851136; rs2953061; rs12273852; rs7931307; rs7946321; rs12290239; rs568310; rs7110097; rs2919057; rs12577127; rs7947586; rs11236282; rs17133586; rs7944151; rs7935409; rs7945382; rs671544; rs7396866; rs4944965; rs725460; rs11236284; rs12277721; rs34937237; rs11236285; rs12277771; rs35707013; rs12291306; rs17133588; rs12278814; rs34908079; rs12792621; rs622578; rs35231407; rs5792677; rs11236283; rs35900546; rs12787292; rs7936236; rs12787310; rs1143370; rs12272790; rs767501; rs34495731; rs3018833; rs12271960; rs35545555; rs1143369; rs4944966; rs35872360; rs35608431; rs11820284; rs2465289; rs1659690; rs12804015; rs7936249; rs17133599; rs35041491; rs4944967; rs35920906; rs7396944; rs35353023; rs12276252; rs12277606; rs10793107; rs10793108; rs11236279; rs11236287; rs11236288; rs11236289; rs11236290; rs11604806; rs11823628; rs12363773; rs1371410; rs1439677; rs17133608; rs17133614; rs2513652; rs4614477; rs4944964; rs537054; rs565377; rs592823; rs594144; rs612439; rs624786; rs639768; rs670246; rs674122; rs685116; rs7111955

# Metabolic_Enzyme_11_General_References:
10405317

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5550

# Metabolic_Enzyme_12_Name:
Galactocerebrosidase precursor

# Metabolic_Enzyme_12_Synonyms:
GALCERase; Galactosylceramidase; Galactosylceramide beta-galactosidase; Galactocerebroside beta-galactosidase

# Metabolic_Enzyme_12_Gene_Name:
GALC

# Metabolic_Enzyme_12_Protein_Sequence:
>Galactocerebrosidase precursor
MTAAAGSAGRAAVPLLLCALLAPGGAYVLDDSDGLGREFDGIGAVSGGGATSRLLVNYPE
PYRSQILDYLFKPNFGASLHILKVEIGGDGQTTDGTEPSHMHYALDENYFRGYEWWLMKE
AKKRNPNITLIGLPWSFPGWLGKGFDWPYVNLQLTAYYVVTWIVGAKRYHDLDIDYIGIW
NERSYNANYIKILRKMLNYQGLQRVKIIASDNLWESISASMLLDAELFKVVDVIGAHYPG
THSAKDAKLTGKKLWSSEDFSTLNSDMGAGCWGRILNQNYINGYMTSTIAWNLVASYYEQ
LPYGRCGLMTAQEPWSGHYVVESPVWVSAHTTQFTQPGWYYLKTVGHLEKGGSYVALTDG
LGNLTIIIETMSHKHSKCIRPFLPYFNVSQQFATFVLKGSFSEIPELQVWYTKLGKTSER
FLFKQLDSLWLLDSDGSFTLSLHEDELFTLTTLTTGRKGSYPLPPKSQPFPSTYKDDFNV
DYPFFSEAPNFADQTGVFEYFTNIEDPGEHHFTLRQVLNQRPITWAADASNTISIIGDYN
WTNLTIKCDVYIETPDTGGVFIAGRVNKGGILIRSARGIFFWIFANGSYRVTGDLAGWII
YALGRVEVTAKKWYTLTLTIKGHFASGMLNDKSLWTDIPVNFPKNGWAAIGTHSFEFAQF
DNFLVEATR

# Metabolic_Enzyme_12_Number_of_Residues:
669

# Metabolic_Enzyme_12_Molecular_Weight:
75148

# Metabolic_Enzyme_12_Theoretical_pI:
6.41

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  galactosylceramidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  glycolipid metabolism
Process:  glycosylceramide metabolism
Process:  galactosylceramide metabolism
Process:  galactosylceramide catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Not Available

# Metabolic_Enzyme_12_Specific_Function:
Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon

# Metabolic_Enzyme_12_Pathway:
map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_12_Reaction:
D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF02057:Glyco_hydro_59

# Metabolic_Enzyme_12_Signals:
1-26

# Metabolic_Enzyme_12_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 3.2.1.46

# Metabolic_Enzyme_12_GenBank_ID_Protein:
457444

# Metabolic_Enzyme_12_SwissProt_ID:
GALC_HUMAN (P54803)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
GALC

# Metabolic_Enzyme_12_Geneatlas_id:
GALC

# Metabolic_Enzyme_12_hgnc_id:
HGNC:4115

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_12_Gene_Sequence:
>2010 bp
ATGACTGCGGCCGCGGGTTCGGCGGGCCGCGCCGCGGTGCCCTTGCTGCTGTGTGCGCTG
CTGGCGCCCGGCGGCGCGTACGTGCTCGACGACTCCGACGGGCTGGGCCGGGAGTTCGAC
GGCATCGGCGCGGTCAGCGGCGGCGGGGCAACCTCCCGACTTCTAGTAAATTACCCAGAG
CCCTATCGTTCTCAGATATTGGATTATCTCTTTAAGCCGAATTTTGGTGCCTCTTTGCAT
ATTTTAAAAGTGGAAATAGGTGGTGATGGGCAGACAACAGACGGCACTGAGCCCTCCCAC
ATGCATTATGCACTAGATGAGAATTATTTCCGAGGATACGAGTGGTGGTTGATGAAAGAA
GCTAAGAAGAGGAATCCCAATATTACACTCATTGGGTTGCCATGGTCATTCCCTGGATGG
CTGGGAAAAGGTTTCGACTGGCCTTATGTCAATCTTCAGCTGACTGCCTATTATGTCGTG
ACCTGGATTGTGGGCGCCAAGCGTTACCATGATTTGGACATTGATTATATTGGAATTTGG
AATGAGAGGTCATATAATGCCAATTATATTAAGATATTAAGAAAAATGCTGAATTATCAA
GGTCTCCAGCGAGTGAAAATCATAGCAAGTGATAATCTCTGGGAGTCCATCTCTGCATCC
ATGCTCCTTGATGCCGAACTCTTCAAGGTGGTTGATGTTATAGGGGCTCATTATCCTGGA
ACCCATTCAGCAAAAGATGCAAAGTTGACTGGGAAGAAGCTTTGGTCTTCTGAAGACTTT
AGCACTTTAAATAGTGACATGGGTGCAGGCTGCTGGGGTCGCATTTTAAATCAGAATTAT
ATCAATGGCTATATGACTTCCACAATCGCATGGAATTTAGTGGCTAGTTACTATGAACAG
TTGCCTTATGGGAGATGCGGGTTGATGACGGCCCAAGAGCCATGGAGTGGGCACTACGTG
GTAGAATCTCCTGTCTGGGTATCAGCTCATACCACTCAGTTTACTCAACCTGGCTGGTAT
TACCTGAAGACAGTTGGCCATTTAGAGAAAGGAGGAAGCTACGTAGCTCTGACTGATGGC
TTAGGGAACCTCACCATCATCATTGAAACCATGAGTCATAAACATTCTAAGTGCATACGG
CCATTTCTTCCTTATTTCAATGTGTCACAACAATTTGCCACCTTTGTTCTTAAGGGATCT
TTTAGTGAAATACCAGAGCTACAGGTATGGTATACCAAACTTGGAAAAACATCCGAAAGA
TTTCTTTTTAAGCAGCTGGATTCTCTATGGCTCCTTGACAGCGATGGCAGTTTCACACTG
AGCCTGCATGAAGATGAGCTGTTCACACTCACCACTCTCACCACTGGTCGCAAAGGCAGC
TACCCGCTTCCTCCAAAATCCCAGCCCTTCCCAAGTACCTATAAGGATGATTTCAATGTT
GATTACCCATTTTTTAGTGAAGCTCCAAACTTTGCTGATCAAACTGGTGTATTTGAATAT
TTTACAAATATTGAAGACCCTGGCGAGCATCACTTCACGCTACGCCAAGTTCTCAACCAG
AGACCCATTACGTGGGCTGCCGATGCATCCAACACAATCAGTATTATAGGAGACTACAAC
TGGACCAATCTGACTATAAAGTGTGATGTTTACATAGAGACCCCTGACACAGGAGGTGTG
TTCATTGCAGGAAGAGTAAATAAAGGTGGTATTTTGATTAGAAGTGCCAGAGGAATTTTC
TTCTGGATTTTTGCAAATGGATCTTACAGGGTTACAGGTGATTTAGCTGGATGGATTATA
TATGCTTTAGGACGTGTTGAAGTTACAGCAAAAAAATGGTATACACTCACGTTAACTATT
AAGGGTCATTTCGCCTCTGGCATGCTGAATGACAAGTCTCTGTGGACAGACATCCCTGTG
AATTTTCCAAAGAATGGCTGGGCTGCAATTGGAACTCACTCCTTTGAATTTGCACAGTTT
GACAACTTTCTTGTGGAAGCCACACGCTAA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
D25283

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_12_Locus:
14q31

# Metabolic_Enzyme_12_SNPs:
rs398607; rs17687109; rs1805078; rs34362748; rs398076; rs3213918; rs12888666; rs421466; rs367327; rs412915; rs432946; rs1042042; rs17198; rs405567; rs1042029; rs16415; rs370559; rs413750; rs366615; rs380557; rs415076; rs429923; rs413420; rs365448; rs378816; rs2285009; rs367636; rs381069; rs8012190; rs376222; rs429176; rs2896069; rs450976; rs11621530; rs422608; rs3844023; rs4445832; rs2269313; rs450711; rs2289511; rs368159; rs2269315; rs12432149; rs452307; rs10142115; rs12434297; rs3910683; rs12883250; rs2301123; rs2301121; rs449615; rs4254268; rs3850378; rs2301120; rs383994; rs10144207; rs3850377; rs3213916; rs7161703; rs10483988; rs2165567; rs3906822; rs451554; rs2236362; rs17123948; rs417276; rs367221; rs2285011; rs17687364; rs12433598; rs431081; rs2301122; rs7141758; rs2119702; rs17203398; rs10483987; rs2245387; rs422580; rs17123925; rs405436; rs368585; rs17123933; rs8009445; rs3213917; rs408667; rs432425; rs2269312; rs2301118; rs17687144; rs3844024; rs4904408; rs3910682; rs432822; rs2285008; rs421749; rs10137195; rs439833; rs17760204; rs417452; rs440770; rs8019944; rs2044066; rs400777; rs17687474; rs434894; rs425189; rs443013; rs390521; rs367125; rs8014798; rs445148; rs431748; rs12433036; rs17798005; rs8015102; rs17123955; rs433764; rs10138271; rs17123957; rs17760374; rs11848601; rs17687329; rs17687486; rs17686897; rs4462528; rs434541; rs17203405; rs7152881; rs366888; rs427018; rs431532; rs385108; rs17203391; rs387768; rs422566; rs397644; rs429170; rs11851130; rs8014856; rs10144227; rs17687383; rs430536; rs17759953; rs17686916; rs435977; rs451073; rs3911142; rs448805; rs10133753; rs428542; rs417521; rs116571; rs3906821; rs17687510; rs7157799; rs3213915; rs17203370; rs10134254; rs394171; rs419458; rs17123945; rs11159832; rs447852; rs398343; rs17759941; rs17760655; rs17123928; rs384152; rs17797987; rs1745638; rs435412; rs11624233; rs17760463; rs379911; rs10140207; rs17797969; rs404356; rs450327; rs12586894; rs448550; rs386079; rs17759543; rs17760434; rs12587119; rs440426; rs444902; rs17797993; rs17760198; rs17687346; rs17760547; rs2119701; rs17760097; rs10135767; rs2165568; rs17759366; rs17760079; rs364400; rs17760451; rs17760679; rs17798011; rs17797981; rs11848620; rs2984825; rs11849742; rs4547273; rs11159831; rs4537954; rs1745636; rs10142621; rs8007437; rs8007714; rs10142611; rs1745637; rs3759712; rs1661321; rs421262; rs34134328; rs17853648; rs9672064; rs12888640; rs3850376; rs1803611; rs1042035; rs1042030; rs35316259; rs28587714; rs10138763; rs34663358; rs1661318; rs2119703; rs28550284; rs33965148; rs1059766; rs28823368; rs36125146; rs390474; rs33970075; rs34185813; rs4899931; rs35893375; rs34700029; rs1745639; rs34172498; rs2269314; rs35477808; rs35425994; rs35430972; rs2760249; rs1661325; rs35250294; rs33990647; rs36115328; rs34309885; rs424977; rs34703156; rs10151403; rs28828442; rs36113094; rs10650123; rs10130189; rs11374703; rs35635941; rs35204698; rs35799492; rs2896067; rs35327812; rs389253; rs12895841; rs4513033; rs715273; rs398075; rs4580092; rs10133933; rs11340776; rs442118; rs7492380; rs410117; rs33937528; rs35140407; rs35426089; rs4420457; rs454425; rs36205603; rs5810392; rs2301119; rs11340777; rs404078; rs3994055; rs443019; rs28821481; rs4294746; rs12895836; rs28535340; rs36062818; rs10147014; rs28436151; rs28368943; rs422840; rs411510; rs11460862; rs4904409; rs423920; rs12881008; rs8016551; rs429544; rs406458; rs418152; rs33973476; rs28516590; rs33935176; rs12586804; rs41366148; rs433738; rs41430647; rs34752717; rs35627403; rs4899930; rs35145882; rs10129418; rs35520077; rs35795072; rs2285010; rs11300320; rs404731; rs33969745; rs10130326; rs12100915; rs35609815; rs35896194; rs1661319; rs4283160; rs7149483; rs28414497; rs3054924; rs10083507; rs440934; rs3216701; rs10528386; rs12896002; rs454053; rs410116; rs417504; rs12895719; rs17123944; rs35503194; rs11415579; rs35427557; rs366323; rs10130062; rs12895721; rs3891494; rs35991879; rs5810391; rs11621556; rs35036230; rs1661323; rs28623317; rs1661322; rs34551700; rs366483; rs12880526; rs12885948; rs34163770; rs1661324; rs2984826; rs2919913; rs10220572; rs119512; rs12879345; rs12880714; rs12881373; rs2165569; rs3911141; rs3943657; rs397480; rs416542; rs417176; rs425598; rs440765; rs4418995; rs4904410; rs8021864; rs930467; rs979812

# Metabolic_Enzyme_12_General_References:
8297359; 8281145; 7601472; 9434153; 8399327; 9338580; 10833326; 7581365; 8595408; 8940268; 8786069; 9272171; 10477434; 10234611

# Metabolic_Enzyme_12_References:
8200356

# Macromolecular_Interacting_Partner_1_ID:
7036

# Macromolecular_Interacting_Partner_1_Name:
Beta-1,3-galactosyltransferase 2

# Macromolecular_Interacting_Partner_1_Synonyms:
Beta-1,3-GalTase 2; Beta3Gal-T2; UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta- galactosyltransferase 2

# Macromolecular_Interacting_Partner_1_Gene_Name:
B3GALT2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Beta1,3galactosyltransferase 2
MLQWRRRHCCFAKMTWNAKRSLFRTHLIGVLSLVFLFAMFLFFNHHDWLPGRAGFKENPV
TYTFRGFRSTKSETNHSSLRNIWKETVPQTLRPQTATNSNNTDLSPQGVTGLENTLSANG
SIYNEKGTGHPNSYHFKYIINEPEKCQEKSPFLILLIAAEPGQIEARRAIRQTWGNESLA
PGIQITRIFLLGLSIKLNGYLQRAILEESRQYHDIIQQEYLDTYYNLTIKTLMGMNWVAT
YCPHIPYVMKTDSDMFVNTEYLINKLLKPDLPPRHNYFTGYLMRGYAPNRNKDSKWYMPP
DLYPSERYPVFCSGTGYVFSGDLAEKIFKVSLGIRRLHLEDVYVGICLAKLRIDPVPPPN
EFVFNHWRVSYSSCKYSHLITSHQFQPSELIKYWNHLQQNKHNACANAAKEKAGRYRHRK
LH

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
422

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
49214

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
9.81

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
Function:  galactosyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid glycosylation
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01762:Galactosyl_T

# Macromolecular_Interacting_Partner_1_Signals:
1-38

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
2791315

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
B3GT2_HUMAN (O43825)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
B3GALT2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
B3GALT2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:917

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Probable)

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1269 bp
ATGCTTCAGTGGAGGAGAAGACACTGCTGCTTTGCAAAGATGACCTGGAATGCCAAAAGG
TCTCTGTTCCGCACTCATCTTATTGGAGTACTTTCTCTAGTGTTTCTTTTTGCTATGTTT
TTGTTTTTCAATCATCATGACTGGCTGCCAGGCAGAGCTGGATTCAAAGAAAACCCTGTG
ACATACACTTTCCGAGGATTTCGGTCAACAAAAAGTGAGACAAACCACAGCTCCCTTCGG
AACATTTGGAAAGAAACAGTCCCTCAAACCCTGAGGCCTCAAACAGCAACTAACTCTAAT
AACACAGACCTGTCACCACAAGGAGTTACAGGCCTGGAGAATACACTTAGTGCCAATGGA
AGTATTTACAATGAAAAAGGTACTGGACATCCAAATTCTTACCATTTCAAATATATTATT
AATGAGCCTGAAAAATGCCAAGAGAAAAGTCCTTTTTTAATACTACTAATAGCTGCAGAG
CCTGGACAAATAGAAGCTAGAAGAGCTATTCGGCAAACTTGGGGCAATGAAAGTCTAGCA
CCTGGTATTCAAATCACAAGAATATTTTTGTTGGGCTTAAGTATTAAGCTAAATGGCTAC
CTTCAACGTGCAATACTGGAAGAAAGCAGACAATATCATGATATAATTCAACAGGAATAC
TTAGATACGTACTATAATTTGACCATTAAAACACTAATGGGCATGAACTGGGTTGCAACA
TACTGTCCACATATTCCATATGTTATGAAAACTGACAGTGACATGTTTGTCAACACTGAA
TATTTAATCAATAAGTTACTGAAGCCAGATCTGCCTCCCAGACATAACTATTTCACTGGT
TACCTAATGCGAGGATATGCACCCAATCGAAACAAAGATAGCAAGTGGTACATGCCACCA
GACCTCTACCCAAGTGAGCGTTATCCTGTCTTCTGTTCTGGAACTGGTTATGTTTTTTCT
GGAGATCTGGCAGAAAAGATTTTTAAAGTTTCTTTAGGTATCCGCCGTTTGCACTTGGAA
GATGTATATGTAGGGATCTGTCTTGCCAAGTTGAGAATTGATCCTGTACCCCCTCCCAAT
GAGTTTGTGTTCAATCACTGGCGAGTCTCTTATTCGAGCTGTAAATACAGCCACCTAATT
ACCTCTCATCAGTTCCAGCCTAGTGAACTGATAAAATACTGGAACCATTTACAACAAAAT
AAGCACAATGCCTGTGCCAACGCAGCAAAAGAAAAGGCAGGCAGGTATCGCCACCGTAAA
CTACATTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
Y15014

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_1_Locus:
1q31

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
9417100; 9582303; 11318611

# Macromolecular_Interacting_Partner_1_References:
11740154; 1755837; 8481397; 8724138

# Macromolecular_Interacting_Partner_2_ID:
7551

# Macromolecular_Interacting_Partner_2_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_2_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_2_Locus:
6p21.3

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_2_References:
15668227; 9763522; 9852101

# Macromolecular_Interacting_Partner_3_ID:
7566

# Macromolecular_Interacting_Partner_3_Name:
Integrin beta-2 precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
Cell surface adhesion glycoproteins LFA- 1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD18 antigen

# Macromolecular_Interacting_Partner_3_Gene_Name:
ITGB2

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Integrin beta2 precursor
MLGLRPPLLALVGLLSLGCVLSQECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSI
RCDTRPQLLMRGCAADDIMDPTSLAETQEDHNGGQKQLSPQKVTLYLRPGQAAAFNVTFR
RAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFV
NTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAM
MQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFD
YPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVQLIKNAY
NKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATEC
IQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKN
CECQTQGRSSQELEGSCRKDNNSIICSGLGDCVCGQCLCHTSDVPGKLIYGQYCECDTIN
CERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCERTTEGCLNPRRVECSGRGRCRCNV
CECHSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGPFGKNCSAACPGLQLSNNPVKGR
TCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRECVAGPNIAAIVGGTVAGIVLIGILLL
VIWKALIHLSDLREYRRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
769

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
84783

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.94

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  development
Process:  cell-substrate adhesion
Process:  cell-matrix adhesion
Process:  cellular process
Process:  cell adhesion
 ||
>>>
Component:  protein complex
Component:  receptor complex
Component:  integrin complex

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF07974:EGF_2;
PF08725:Integrin_b_cyt;
PF07965:Integrin_B_tail;
PF00362:Integrin_beta

# Macromolecular_Interacting_Partner_3_Signals:
1-22

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
701-723

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
307113

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
ITB2_HUMAN (P05107)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
ITGB2

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
ITGB2

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:6155

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>2310 bp
ATGCTGGGCCTGCGCCCCCCACTGCTCGCCCTGGTGGGGCTGCTCTCCCTCGGGTGCGTC
CTCTCTCAGGAGTGCACGAAGTTCAAGGTCAGCAGCTGCCGGGAATGCATCGAGTCGGGG
CCCGGCTGCACCTGGTGCCAGAAGCTGAACTTCACAGGGCCGGGGGATCCTGACTCCATT
CGCTGCGACACCCGGCCACAGCTGCTCATGAGGGGCTGTGCGGCTGACGACATCATGGAC
CCCACAAGCCTCGCTGAAACCCAGGAAGACCACAATGGGGGCCAGAAGCAGCTGTCCCCA
CAAAAAGTGACGCTTTACCTGCGACCAGGCCAGGCAGCAGCGTTCAACGTGACCTTCCGG
CGGGCCAAGGGCTACCCCATCGACCTGTACTATCTGATGGACCTCTCCTACTCCATGCTT
GATGACCTCAGGAATGTCAAGAAGCTAGGTGGCGACCTGCTCCGGGCCCTCAACGAGATC
ACCGAGTCCGGCCGCATTGGCTTCGGGTCCTTCGTGGACAAGACCGTGCTGCCGTTCGTG
AACACGCACCCTGATAAGCTGCGAAACCCATGCCCCAACAAGGAGAAAGAGTGCCAGCCC
CCGTTTGCCTTCAGGCACGTGCTGAAGCTGACCAACAACTCCAACCAGTTTCAGACCGAG
GTCGGGAAGCAGCTGATTTCCGGAAACCTGGATGCACCCGAGGGTGGGCTGGACGCCATG
ATGCAGGTCGCCGCCTGCCCGGAGGAAATCGGCTGGCGCAACGTCACGCGGCTGCTGGTG
TTTGCCACTGATGACGGCTTCCATTTCGCGGGCGACGGAAAGCTGGGCGCCATCCTGACC
CCCAACGACGGCCGCTGTCACCTGGAGGACAACTTGTACAAGAGGAGCAACGAATTCGAC
TACCCATCGGTGGGCCAGCTGGCGCACAAGCTGGCTGAAAACAACATCCAGCCCATCTTC
GCGGTGACCAGTAGGATGGTGAAGACCTACGAGAAACTCACCGAGATCATCCCCAAGTCA
GCCGTGGGGGAGCTGTCTGAGGACTCCAGCAATGTGGTCCATCTCATTAAGAATGCTTAC
AATAAACTCTCCTCCAGGGTCTTCCTGGATCACAACGCCCTCCCCGACACCCTGAAAGTC
ACCTACGACTCCTTCTGCAGCAATGGAGTGACGCACAGGAACCAGCCCAGAGGTGACTGT
GATGGCGTGCAGATCAATGTCCCGATCACCTTCCAGGTGAAGGTCACGGCCACAGAGTGC
ATCCAGGAGCAGTCGTTTGTCATCCGGGCGCTGGGCTTCACGGACATAGTGACCGTGCAG
GTTCTTCCCCAGTGTGAGTGCCGGTGCCGGGACCAGAGCAGAGACCGCAGCCTCTGCCAT
GGCAAGGGCTTCTTGGAGTGCGGCATCTGCAGGTGTGACACTGGCTACATTGGGAAAAAC
TGTGAGTGCCAGACACAGGGCCGGAGCAGCCAGGAGCTGGAAGGAAGCTGCCGGAAGGAC
AACAACTCCATCATCTGCTCAGGGCTGGGGGACTGTGTCTGCGGGCAGTGCCTGTGCCAC
ACCAGCGACGTCCCCGGCAAGCTGATATACGGGCAGTACTGCGAGTGTGACACCATCAAC
TGTGAGCGCTACAACGGCCAGGTCTGCGGCGGCCCGGGGAGGGGGCTCTGCTTCTGCGGG
AAGTGCCGCTGCCACCCGGGCTTTGAGGGCTCAGCGTGCCAGTGCGAGAGGACCACTGAG
GGCTGCCTGAACCCGCGGCGTGTTGAGTGTAGTGGTCGTGGCCGGTGCCGCTGCAACGTA
TGCGAGTGCCATTCAGGCTACCAGCTGCCTCTGTGCCAGGAGTGCCCCGGCTGCCCCTCA
CCCTGTGGCAAGTACATCTCCTGCGCCGAGTGCCTGAAGTTCGAAAAGGGCCCCTTTGGG
AAGAACTGCAGCGCGGCGTGTCCGGGCCTGCAGCTGTCGAACAACCCCGTGAAGGGCAGG
ACCTGCAAGGAGAGGGACTCAGAGGGCTGCTGGGTGGCCTACACGCTGGAGCAGCAGGAC
GGGATGGACCGCTACCTCATCTATGTGGATGAGAGCCGAGAGTGTGTGGCAGGCCCCAAC
ATCGCCGCCATCGTCGGGGGCACCGTGGCAGGCATCGTGCTGATCGGCATTCTCCTGCTG
GTCATCTGGAAGGCTCTGATCCACCTGAGCGACCTCCGGGAGTACAGGCGCTTTGAGAAG
GAGAAGCTCAAGTCCCAGTGGAACAATGATAATCCCCTTTTCAAGAGCGCCACCACGACG
GTCATGAACCCCAAGTTTGCTGAGAGTTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
M15395

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_3_Locus:
Not Available

# Macromolecular_Interacting_Partner_3_SNPs:
rs235326; rs5030671; rs11559271; rs2230530; rs17004713; rs2838736; rs1474552; rs2838737; rs760453; rs684; rs3788151; rs6518205; rs9306118; rs2838735; rs1160263; rs2070947; rs760452; rs2006272; rs760454; rs3788150; rs6570; rs2017725; rs2013275; rs9976299; rs873556; rs3859733; rs8130796; rs2006271; rs12626729; rs11702367; rs12626397; rs12482072; rs9980413; rs12481877; rs7277900; rs13051783; rs741961; rs7282310; rs3788149; rs235325; rs235327; rs2838734; rs2838729; rs2235133; rs760464; rs2838728; rs760456; rs1970054; rs2838730; rs2838726; rs235329; rs2838733; rs760459; rs1040368; rs2838727; rs2838732; rs2838725; rs2011655; rs2026882; rs2075883; rs1041457; rs8128353; rs3788145; rs2075884; rs8127060; rs909427; rs235333; rs17004715; rs235328; rs760457; rs235331; rs173098; rs235375; rs760463; rs2280965; rs180318; rs760458; rs2072702; rs3788142; rs7281826; rs4607021; rs3746972; rs2072703; rs183517; rs12627407; rs7281624; rs2329940; rs11911476; rs760460; rs10854466; rs235332; rs760462; rs3838127; rs8131627; rs170963; rs5030668; rs12626524; rs4818740; rs12627394; rs12626539; rs9979014; rs381406; rs2070946; rs13053009; rs3761396; rs2776388; rs5844205; rs5030672; rs235330; rs2230531; rs5030667; rs11088969; rs35903905; rs35013643; rs35370671; rs34142945; rs7280802; rs35960094; rs28462282; rs13050770; rs1063594; rs1140646; rs6650861; rs28619388; rs7281781; rs7278533; rs4050930; rs35600688; rs33944707; rs873555; rs11559270; rs13052421; rs33910938; rs35735704; rs7281925; rs34787599; rs11380568; rs13047425; rs34550180; rs28726107; rs34034119; rs35517302; rs34516301; rs11404188; rs28461884; rs28671131; rs36009514; rs13052567; rs35925893; rs35429579; rs13052681; rs28675066; rs34404406; rs35779896; rs9980361; rs882549; rs33973568; rs28438743; rs3838128; rs35585534; rs10542500; rs28659859; rs35723624; rs34527545; rs13048495; rs11327948; rs9976146; rs35308373; rs28760483; rs8134406; rs34110149; rs3746973; rs3788143; rs10676204; rs11909538; rs7281466; rs5030670; rs5844206; rs36017031; rs11358577; rs2026881; rs35243292; rs11277171; rs35280729; rs34957139; rs5030673; rs10542501; rs34031498; rs34063651; rs13049353; rs3788146; rs35293792; rs235377; rs35380759; rs34020918; rs35963032; rs35004247; rs35934861; rs9980891; rs36082126; rs34675004; rs7280650; rs35162504; rs34580582; rs35871743; rs35203235; rs8132181; rs5030627; rs11909537; rs8127938; rs3788147; rs36005994; rs5030669; rs10545266; rs34832094; rs34546748; rs3054411; rs35990506; rs28568522; rs9983887; rs235376; rs11290452; rs1160038; rs35928353; rs4999987; rs6147533; rs28415767; rs4999985; rs35861170; rs28497442; rs3761397; rs5844203; rs11701757; rs2776387; rs35482976; rs5030666; rs10532717; rs5844204; rs28568877; rs4999986; rs3761394; rs34045410; rs2570975; rs11701749; rs28575563; rs3761395; rs28373949; rs17004716; rs34733702; rs35365196; rs11702770; rs125810; rs170962; rs1721; rs2117341; rs2164072; rs235305; rs235306; rs2838723; rs2838724; rs2838738; rs2838739; rs2838740; rs2838741; rs34552233; rs34897870; rs3810586; rs4050931; rs417580; rs440555; rs441019; rs450206; rs4818983; rs4818984; rs4818985; rs4818986; rs4818987; rs714946; rs714947; rs7280520; rs760434; rs760435; rs990594; rs991340; rs9983174

# Macromolecular_Interacting_Partner_3_General_References:
3028646; 1683838; 10830953; 2954816; 1346613; 10766246; 11700305; 1694220; 1352501; 1968911; 1347532; 1590804; 7686755; 9884339

# Macromolecular_Interacting_Partner_3_References:
9529158; 9763522

# Macromolecular_Interacting_Partner_4_ID:
7571

# Macromolecular_Interacting_Partner_4_Name:
Intercellular adhesion molecule 1 precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
ICAM-1; Major group rhinovirus receptor; CD54 antigen

# Macromolecular_Interacting_Partner_4_Gene_Name:
ICAM1

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Intercellular adhesion molecule 1 precursor
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGI
ETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAP
LPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHH
GANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLD
GLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQE
TLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKA
TPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQ
AWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYE
IVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
532

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
57826

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.06

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular process
Process:  cell adhesion
Process:  cell-cell adhesion
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
ICAM proteins are ligands for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2)

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF03921:ICAM_N

# Macromolecular_Interacting_Partner_4_Signals:
1-27

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
481-503

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
758074

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
ICAM1_HUMAN (P05362)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
ICAM1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
ICAM1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:5344

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1599 bp
ATGGCTCCCAGCAGCCCCCGGCCCGCGCTGCCCGCACTCCTGGTCCTGCTCGGGGCTCTG
TTCCCAGGACCTGGCAATGCCCAGACATCTGTGTCCCCCTCAAAAGTCATCCTGCCCCGG
GGAGGCTCCGTGCTGGTGACATGCAGCACCTCCTGTGACCAGCCCAAGTTGTTGGGCATA
GAGACCCCGTTGCCTAAAAAGGAGTTGCTCCTGCCTGGGAACAACCGGAAGGTGTATGAA
CTGAGCAATGTGCAAGAAGATAGCCAACCAATGTGCTATTCAAACTGCCCTGATGGGCAG
TCAACAGCTAAAACCTTCCTCACCGTGTACTGGACTCCAGAACGGGTGGAACTGGCACCC
CTCCCCTCTTGGCAGCCAGTGGGCAAGAACCTTACCCTACGCTGCCAGGTGGAGGGTGGG
GCACCCCGGGCCAACCTCACCGTGGTGCTGCTCCGTGGGGAGAAGGAGCTGAAACGGGAG
CCAGCTGTGGGGGAGCCCGCTGAGGTCACGACCACGGTGCTGGTGAGGAGAGATCACCAT
GGAGCCAATTTCTCGTGCCGCACTGAACTGGACCTGCGGCCCCAAGGGCTGGAGCTGTTT
GAGAACACCTCGGCCCCCTACCAGCTCCAGACCTTTGTCCTGCCAGCGACTCCCCCACAA
CTTGTCAGCCCCCGGGTCCTAGAGGTGGACACGCAGGGGACCGTGGTCTGTTCCCTGGAC
GGGCTGTTCCCAGTCTCGGAGGCCCAGGTCCACCTGGCACTGGGGGACCAGAGGTTGAAC
CCCACAGTCACCTATGGCAACGACTCCTTCTCGGCCAAGGCCTCAGTCAGTGTGACCGCA
GAGGACGAGGGCACCCAGCGGCTGACGTGTGCAGTAATACTGGGGAACCAGAGCCAGGAG
ACACTGCAGACAGTGACCATCTACAGCTTTCCGGCGCCCAACGTGATTCTGACGAAGCCA
GAGGTCTCAGAAGGGACCGAGGTGACAGTGAAGTGTGAGGCCCACCCTAGAGCCAAGGTG
ACGCTGAATGGGGTTCCAGCCCAGCCACTGGGCCCGAGGGCCCAGCTCCTGCTGAAGGCC
ACCCCAGAGGACAACGGGCGCAGCTTCTCCTGCTCTGCAACCCTGGAGGTGGCCGGCCAG
CTTATACACAAGAACCAGACCCGGGAGCTTCGTGTCCTGTATGGCCCCCGACTGGACGAG
AGGGATTGTCCGGGAAACTGGACGTGGCCAGAAAATTCCCAGCAGACTCCAATGTGCCAG
GCTTGGGGGAACCCATTGCCCGAGCTCAAGTGTCTAAAGGATGGCACTTTCCCACTGCCC
ATCGGGGAATCAGTGACTGTCACTCGAGATCTTGAGGGCACCTACCTCTGTCGGGCCAGG
AGCACTCAAGGGGAGGTCACCCGCGAGGTGACCGTGAATGTGCTCTCCCCCCGGTATGAG
ATTGTCATCATCACTGTGGTAGCAGCCGCAGTCATAATGGGCACTGCAGGCCTCAGCACG
TACCTCTATAACCGCCAGCGGAAGATCAAGAAATACAGACTACAACAGGCCCAAAAAGGG
ACCCCCATGAAACCGAACACACAAGCCACGCCTCCCTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
X06990

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_4_Locus:
19p13.3-p13.2

# Macromolecular_Interacting_Partner_4_SNPs:
rs5491; rs1801714; rs5497; rs1799969; rs5494; rs5493; rs5030381; rs13306429; rs35956512; rs5490; rs13306427; rs36086415; rs281433; rs5030377; rs281432; rs281431; rs5030348; rs281430; rs5030351; rs5030362; rs5030352; rs5030340; rs5030370; rs3093035; rs5030391; rs5030365; rs5030347; rs5496; rs281434; rs281428; rs5030354; rs5030364; rs12462944; rs5030395; rs281429; rs5030368; rs5030393; rs11667983; rs5030380; rs5030343; rs5030398; rs5030376; rs5030353; rs5030366; rs5030367; rs11879117; rs5030341; rs5030344; rs5030356; rs5030397; rs5030346; rs12459133; rs3093033; rs5030390; rs2358581; rs5030379; rs7258215; rs5030339; rs5030388; rs5030386; rs35501657; rs422429; rs13306430; rs5495; rs34369517; rs5492; rs2071441; rs372336; rs1800019; rs41520346; rs41276880; rs5030363; rs35769997; rs35660845; rs5030355; rs5030349; rs5030345; rs5030392; rs5030374; rs11575070; rs33958632; rs34542691; rs5030394; rs41360047; rs34215251; rs35590890; rs34434348; rs5030361; rs5030357; rs5030378; rs13306428; rs3073809; rs5030371; rs11575071; rs5030359; rs5030369; rs35871840; rs5030360; rs5030358; rs5827095; rs28432861; rs10420063; rs5030342; rs5030350; rs5030396; rs5030372; rs5030375; rs5030399; rs34496081; rs11575072; rs5030387; rs35643518; rs36213467; rs34546385; rs34876098; rs36213469; rs41468345; rs10402760; rs1056536; rs1056538; rs1057981; rs11575074; rs11669397; rs12972990; rs17852402; rs2071440; rs2075741; rs2075742; rs2228615; rs2569693; rs2569694; rs2569695; rs2569697; rs2569698; rs2569700; rs2569701; rs2569702; rs2569703; rs2569704; rs2569706; rs2569708; rs2735439; rs2735440; rs2735442; rs281437; rs281438; rs281439; rs281440; rs2916058; rs2916060; rs3093030; rs3093032; rs34918248; rs35318566; rs36045754; rs3810159; rs5030384; rs5030385; rs5030400; rs5499; rs5501; rs710845; rs735747; rs885743; rs901886

# Macromolecular_Interacting_Partner_4_General_References:
3340213; 3349522; 2544880; 1680919; 1983003; 2538243; 9539702; 9539703; 10562537; 7525451; 8557254; 9259284; 10391210

# Macromolecular_Interacting_Partner_4_References:
11740154; 9852101

# Macromolecular_Interacting_Partner_5_ID:
7599

# Macromolecular_Interacting_Partner_5_Name:
Proliferating cell nuclear antigen

# Macromolecular_Interacting_Partner_5_Synonyms:
PCNA; Cyclin

# Macromolecular_Interacting_Partner_5_Gene_Name:
PCNA

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Proliferating cell nuclear antigen
MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTY
RCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMD
LDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNI
KLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYK
IADMGHLKYYLAPKIEDEEGS

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
261

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
28769

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
4.31

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed DNA polymerase activity
Function:  DNA polymerase processivity factor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of DNA metabolism
Process:  regulation of DNA replication
 ||
>>>
Component:  protein complex
Component:  delta-DNA polymerase cofactor complex
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_5_General_Function:
Replication, recombination and repair 

# Macromolecular_Interacting_Partner_5_Specific_Function:
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF02747:PCNA_C;
PF00705:PCNA_N

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
181272

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
PCNA_HUMAN (P12004)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
PCNA

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
PCNA

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:8729

# Macromolecular_Interacting_Partner_5_PDB_ID:
1U76

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>786 bp
ATGTTCGAGGCGCGCCTGGTCCAGGGCTCCATCCTCAAGAAGGTGTTGGAGGCACTCAAG
GACCTCATCAACGAGGCCTGCTGGGATATTAGCTCCAGCGGTGTAAACCTGCAGAGCATG
GACTCGTCCCACGTCTCTTTGGTGCAGCTCACCCTGCGGTCTGAGGGCTTCGACACCTAC
CGCTGCGACCGCAACCTGGCCATGGGCGTGAACCTCACCAGTATGTCCAAAATACTAAAA
TGCGCCGGCAATGAAGATATCATTACACTAAGGGCCGAAGATAACGCGGATACCTTGGCG
CTAGTATTTGAAGCACCAAACCAGGAGAAAGTTTCAGACTATGAAATGAAGTTGATGGAT
TTAGATGTTGAACAACTTGGAATTCCAGAACAGGAGTACAGCTGTGTAGTAAAGATGCCT
TCTGGTGAATTTGCACGTATATGCCGAGATCTCAGCCATATTGGAGATGCTGTTGTAATT
TCCTGTGCAAAAGACGGAGTGAAATTTTCTGCAAGTGGAGAACTTGGAAATGGAAACATT
AAATTGTCACAGACAAGTAATGTCGATAAAGAGGAGGAAGCTGTTACCATAGAGATGAAT
GAACCAGTTCAACTAACTTTTGCACTGAGGTACCTGAACTTCTTTACAAAAGCCACTCCA
CTCTCTTCAACGGTGACACTCAGTATGTCTGCAGATGTACCCCTTGTTGTAGAGTATAAA
ATTGCGGATATGGGACACTTAAAATACTACTTGGCTCCCAAGATCGAGGATGAAGAAGGA
TCTTAG

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
M15796

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_5_Locus:
20pter-p12

# Macromolecular_Interacting_Partner_5_SNPs:
rs17350; rs17353; rs3730415; rs3626; rs8632; rs3730416; rs3730414; rs6116655; rs6116656; rs34818603; rs3730417; rs3730428; rs3730426; rs17352; rs25405; rs17347; rs17351; rs3730441; rs3730436; rs3730438; rs25406; rs17349; rs3730434; rs3730423; rs3730435; rs3730433; rs3730440; rs17348; rs3730431; rs3730427; rs3730424; rs3730437; rs3730425; rs1050525; rs36228623; rs35106260; rs11482829; rs11700149; rs10712799; rs34987280; rs10712798; rs36228616; rs34188898; rs34672771; rs11469817; rs6139626; rs6139627; rs7263456; rs11543929; rs36228622; rs6139628; rs36228617; rs36228618; rs11481769; rs35623151; rs3730432; rs35240308; rs35258130; rs6139625; rs6107578; rs3730439; rs13037111; rs16990612; rs2083918; rs2423089; rs261345; rs3729558; rs3730445; rs3730446; rs3730447; rs3730448; rs3730449; rs3730450; rs3730453; rs3730455; rs3730456; rs3761241; rs4239761; rs6053127; rs6107576; rs6107577; rs6107581; rs6116651; rs6116652; rs6116653; rs6116654; rs6139624; rs6139635; rs7264821; rs7344137; rs8122586; rs8124482; rs8125170

# Macromolecular_Interacting_Partner_5_General_References:
2882507; 2565339; 11780052; 2882422; 9305916; 9302295; 11376153; 11784855; 12522211; 8861913

# Macromolecular_Interacting_Partner_5_References:
9343929

# Macromolecular_Interacting_Partner_6_ID:
6559

# Macromolecular_Interacting_Partner_6_Name:
Mitogen-activated protein kinase 3

# Macromolecular_Interacting_Partner_6_Synonyms:
Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAPK 1; p44-ERK1; ERT2; p44-MAPK; Microtubule- associated protein 2 kinase

# Macromolecular_Interacting_Partner_6_Gene_Name:
MAPK3

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Mitogenactivated protein kinase 3
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
379

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
43136

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
6.74

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00069:Pkinase

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
EC 2.7.11.24

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
31221

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
MK03_HUMAN (P27361)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
MAPK3

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
MAPK3

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:6877

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1140 bp
ATGGCGGCGGCGGCGGCTCAGGGGGGCGGGGGCGGGGAGCCCCGTAGAACCGAGGGGGTC
GGCCCGGGGGTCCCGGGGGAGGTGGAGATGGTGAAGGGGCAGCCGTTCGACGTGGGCCCG
CGCTACACGCAGTTGCAGTACATCGGCGAGGGCGCGTACGGCATGGTCAGCTCGGCCTAT
GACCACGTGCGCAAGACTCGCGTGGCCATCAAGAAGATCAGCCCCTTCGAACATCAGACC
TACTGCCAGCGCACGCTCCGGGAGATCCAGATCCTGCTGCGCTTCCGCCATGAGAATGTC
ATCGGCATCCGAGACATTCTGCGGGCGTCCACCCTGGAAGCCATGAGAGATGTCTACATT
GTGCAGGACCTGATGGAGACTGACCTGTACAAGTTGCTGAAAAGCCAGCAGCTGAGCAAT
GACCATATCTGCTACTTCCTCTACCAGATCCTGCGGGGCCTCAAGTACATCCACTCCGCC
AACGTGCTCCACCGAGATCTAAAGCCCTCCAACCTGCTCAGCAACACCACCTGCGACCTT
AAGATTTGTGATTTCGGCCTGGCCCGGATTGCCGATCCTGAGCATGACCACACCGGCTTC
CTGACGGAGTATGTGGCTACGCGCTGGTACCGGGCCCCAGAGATCATGCTGAACTCCAAG
GGCTATACCAAGTCCATCGACATCTGGTCTGTGGGCTGCATTCTGGCTGAGATGCTCTCT
AACCGGCCCATCTTCCCTGGCAAGCACTACCTGGATCAGCTCAACCACATTCTGGGCATC
CTGGGCTCCCCATCCCAGGAGGACCTGAATTGTATCATCAACATGAAGGCCCGAAACTAC
CTACAGTCTCTGCCCTCCAAGACCAAGGTGGCTTGGGCCAAGCTTTTCCCCAAGTCAGAC
TCCAAAGCCCTTGACCTGCTGGACCGGATGTTAACCTTTAACCCCAATAAACGGATCACA
GTGGAGGAAGCGCTGGCTCACCCCTACCTGGAGCAGTACTATGACCCGACGGATGAGCCA
GTGGCCGAGGAGCCCTTCACCTTCGCCATGGAGCTGGATGACCTACCTAAGGAGCGGCTG
AAGGAGCTCATCTTCCAGGAGACAGCACGCTTCCAGCCCGGAGTGCTGGAGGCCCCCTAG


# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
X60188

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_6_Locus:
16p11.2

# Macromolecular_Interacting_Partner_6_SNPs:
rs1143695; rs11865086; rs11864737; rs9921806; rs12922100; rs11863765; rs9930013; rs11546680; rs41292376; rs41291696; rs41280862; rs35691465; rs41280866; rs41280860; rs41280864; rs35666305; rs11644927; rs7199920; rs12918285; rs36084237; rs34799400; rs34564246; rs9940575; rs9940581; rs28529403; rs1042404; rs1062543; rs12924137; rs12930241; rs13569; rs1561414; rs2005219; rs3751867; rs7542; rs7698; rs8061772

# Macromolecular_Interacting_Partner_6_General_References:
7687743; 1540184; 1319925; 8794306

# Macromolecular_Interacting_Partner_6_References:
11592959; 8631872; 8808768; 9884018

# Macromolecular_Interacting_Partner_7_ID:
8005

# Macromolecular_Interacting_Partner_7_Name:
Proto-oncogene protein c-fos

# Macromolecular_Interacting_Partner_7_Synonyms:
Cellular oncogene fos; G0/G1 switch regulatory protein 7

# Macromolecular_Interacting_Partner_7_Gene_Name:
FOS

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Protooncogene protein cfos
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANF
IPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRA
QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ
TEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT
LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYA
ADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRK
GSSSNEPSSDSLSSPTLLAL

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
380

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
40696

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
4.50

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, c-fos and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF07716:bZIP_2

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
29904

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
FOS_HUMAN (P01100)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
FOS

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
FOS

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:3796

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1143 bp
ATGATGTTCTCGGGCTTCAACGCAGACTACGAGGCGTCATCCTCCCGCTGCAGCAGCGCG
TCCCCGGCCGGGGATAGCCTCTCTTACTACCACTCACCCGCAGACTCCTTCTCCAGCATG
GGCTCGCCTGTCAACGCGCAGGACTTCTGCACGGACCTGGCCGTCTCCAGTGCCAACTTC
ATTCCCACGGTCACTGCCATCTCGACCAGTCCGGACCTGCAGTGGCTGGTGCAGCCCGCC
CTCGTCTCCTCTGTGGCCCCATCGCAGACCAGAGCCCCTCACCCTTTCGGAGTCCCCGCC
CCCTCCGCTGGGGCTTACTCCAGGGCTGGCGTTGTGAAGACCATGACAGGAGGCCGAGCG
CAGAGCATTGGCAGGAGGGGCAAGGTGGAACAGTTATCTCCAGAAGAAGAAGAGAAAAGG
AGAATCCGAAGGGAAAGGAATAAGATGGCTGCAGCCAAATGCCGCAACCGGAGGAGGGAG
CTGACTGATACACTCCAAGCGGAGACAGACCAACTAGAAGATGAGAAGTCTGCTTTGCAG
ACCGAGATTGCCAACCTGCTGAAGGAGAAGGAAAAACTAGAGTTCATCCTGGCAGCTCAC
CGACCTGCCTGCAAGATCCCTGATGACCTGGGCTTCCCAGAAGAGATGTCTGTGGCTTCC
CTTGATCTGACTGGGGGCCTGCCAGAGGTTGCCACCCCGGAGTCTGAGGAGGCCTTCACC
CTGCCTCTCCTCAATGACCCTGAGCCCAAGCCCTCAGTGGAACCTGTCAAGAGCATCAGC
AGCATGGAGCTGAAGACCGAGCCCTTTGATGACTTCCTGTTCCCAGCATCATCCAGGCCC
AGTGGCTCTGAGACAGCCCGCTCCGTGCCAGACATGGACCTATCTGGGTCCTTCTATGCA
GCAGACTGGGAGCCTCTGCACAGTGGCTCCCTGGGGATGGGGCCCATGGCCACAGAGCTG
GAGCCCCTGTGCACTCCGGTGGTCACCTGTACTCCCAGCTGCACTGCTTACACGTCTTCC
TTCGTCTTCACCTACCCCGAGGCTGACTCCTTCCCCAGCTGTGCAGCTGCCCACCGCAAG
GGCAGCAGCAGCAATGAGCCTTCCTCTGACTCGCTCAGCTCACCCACGCTGCTGGCCCTG
TGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
V01512

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_7_Locus:
14q24.3

# Macromolecular_Interacting_Partner_7_SNPs:
rs2229024; rs1046117; rs4645857; rs7101; rs2239615; rs4645855; rs4645856; rs3216792; rs35706183; rs4645853; rs1063169; rs4645854; rs35586383; rs932257; rs2234706; rs4645850; rs4645859; rs4645852; rs4645849; rs1046283; rs3180688; rs4645858; rs14371; rs11354110; rs35423373; rs4645861; rs4645848; rs10142078; rs4645860; rs4645847; rs4645851; rs1005367; rs1009392; rs10133192; rs10133595; rs10144025; rs11159131; rs1569328; rs17103109; rs3742769; rs3742770; rs4645869; rs4645870; rs4645875; rs4645876; rs4645877; rs4903301; rs4903304; rs6574222; rs7146378; rs7154366; rs926113

# Macromolecular_Interacting_Partner_7_General_References:
6574479; 2516827; 12508121; 1658710; 2511004; 7816143

# Macromolecular_Interacting_Partner_7_References:
8631872; 9254052; 9343929; 9884018

# Macromolecular_Interacting_Partner_8_ID:
8155

# Macromolecular_Interacting_Partner_8_Name:
Platelet endothelial cell adhesion molecule precursor

# Macromolecular_Interacting_Partner_8_Synonyms:
PECAM-1; EndoCAM; GPIIA'; CD31 antigen

# Macromolecular_Interacting_Partner_8_Gene_Name:
PECAM1

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Platelet endothelial cell adhesion molecule precursor
MQPRWAQGATMWLGVLLTLLLCSSLEGQENSFTINSVDMKSLPDWTVQNGKNLTLQCFAD
VSTTSHVKPQHQMLFYKDDVLFYNISSMKSTESYFIPEVRIYDSGTYKCTVIVNNKEKTT
AEYQLLVEGVPSPRVTLDKKEAIQGGIVRVNCSVPEEKAPIHFTIEKLELNEKMVKLKRE
KNSRDQNFVILEFPVEEQDRVLSFRCQARIISGIHMQTSESTKSELVTVTESFSTPKFHI
SPTGMIMEGAQLHIKCTIQVTHLAQEFPEIIIQKDKAIVAHNRHGNKAVYSVMAMVEHSG
NYTCKVESSRISKVSSIVVNITELFSKPELESSFTHLDQGERLNLSCSIPGAPPANFTIQ
KEDTIVSQTQDFTKIASKSDSGTYICTAGIDKVVKKSNTVQIVVCEMLSQPRISYDAQFE
VIKGQTIEVRCESISGTLPISYQLLKTSKVLENSTKNSNDPAVFKDNPTEDVEYQCVADN
CHSHAKMLSEVLRVKVIAPVDEVQISILSSKVVESGEDIVLQCAVNEGSGPITYKFYREK
EGKPFYQMTSNATQAFWTKQKASKEQEGEYYCTAFNRANHASSVPRSKILTVRVILAPWK
KGLIAVVIIGVIIALLIIAAKCYFLRKAKAKQMPVEMSRPAVPLLNSNNEKMSDPNMEAN
SHYGHNDDVRNHAMKPINDNKEPLNSDVQYTEVQVSSAESHKDLGKKDTETVYSEVRKAV
PDAVESRYSRTEGSLDGT

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
738

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
82537

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
6.99

# Macromolecular_Interacting_Partner_8_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
This protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00047:ig

# Macromolecular_Interacting_Partner_8_Signals:
1-27

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
602-620

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
187240

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
PECA1_HUMAN (P16284)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
PECAM1

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
PECAM1

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:8823

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>2217 bp
ATGCAGCCGAGGTGGGCCCAAGGGGCCACGATGTGGCTTGGAGTCCTGCTGACCCTTCTG
CTCTGTTCAAGCCTTGAGGGTCAAGAAAACTCTTTCACAATCAACAGTGTTGACATGAAG
AGCCTGCCGGACTGGACGGTGCAAAATGGGAAGAACCTGACCCTGCAGTGCTTCGCGGAT
GTCAGCACCACCTCTCACGTCAAGCCTCAGCACCAGATGCTGTTCTATAAGGATGACGTG
CTGTTTTACAACATCTCCTCCATGAAGAGCACAGAGAGTTATTTTATTCCTGAAGTCCGG
ATCTATGACTCAGGGACATATAAATGTACTGTGATTGTGAACAACAAAGAGAAAACCACT
GCAGAGTACCAGGTGTTGGTGGAAGGAGTGCCCAGTCCCAGGGTGACACTGGACAAGAAA
GAGGCCATCCAAGGTGGGATCGTGAGGGTCAACTGTTCTGTCCCAGAGGAAAAGGCCCCA
ATACACTTCACAATTGAAAAACTTGAACTAAATGAAAAAATGGTCAAGCTGAAAAGAGAG
AAGAATTCTCGAGACCAGAATTTTGTGATACTGGAATTCCCCGTTGAGGAACAGGACCGC
GTTTTATCCTTCCGATGTCAAGCTAGGATCATTTCTGGGATCCATATGCAGACCTCAGAA
TCTACCAAGAGTGAACTGGTCACCGTGACGGAATCCTTCTCTACACCCAAGTTCCACATC
AGCCCCACCGGAATGATCATGGAAGGAGCTCAGCTCCACATTAAGTGCACCATTCAAGTG
ACTCACCTGGCCCAGGAGTTTCCAGAAATCATAATTCAGAAGGACAAGGCGATTGTGGCC
CACAACAGACATGGCAACAAGGCTGTGTACTCAGTCATGGCCATGGTGGAGCACAGTGGC
AACTACACGTGCAAAGTGGAGTCCAGCCGCATATCCAAGGTCAGCAGCATCGTGGTCAAC
ATAACAGAACTATTTTCCAAGCCCGAACTGGAATCTTCCTTCACACATCTGGACCAAGGT
GAAAGACTGAACCTGTCCTGCTCCATCCCAGGAGCACCTCCAGCCAACTTCACCATCCAG
AAGGAAGATACGATTGTGTCACAGACTCAAGATTTCACCAAGATAGCCTCAAAGTCGGAC
AGTGGGACGTATATCTGCACTGCAGGTATTGACAAAGTGGTCAAGAAAAGCAACACAGTC
CAGATAGTCGTATGTGAAATGCTCTCCCAGCCCAGGATTTCTTATGATGCCCAGTTTGAG
GTCATAAAAGGACAGACCATCGAAGTCCGTTGCGAATCGATCAGTGGAACTTTGCCTATT
TCTTACCAACTTTTAAAAACAAGTAAAGTTTTGGAGAATAGTACCAAGAACTCAAATGAT
CCTGCGGTATTCAAAGACAACCCCACTGAAGACGTCGAATACCAGTGTGTTGCAGATAAT
TGCCATTCCCACGCCAAAATGTTAAGTGAGGTTCTGAGGGTGAAGGTGATAGCCCCGGTG
GATGAGGTCCAGATTTCTATCCTGTCAAGTAAGGTGGTGGAGTCTGGAGAGGACATTGTG
CTGCAATGTGCTGTGAATGAAGGATCTGGTCCCATCACCTATAAGTTTTACAGAGAAAAA
GAGGGCAAACCCTTCTATCAAATGACCTCAAATGCCACCCAGGCATTTTGGACCAAGCAG
AAGGCTAACAAGGAACAGGAGGGAGAGTATTACTGCACAGCCTTCAACAGAGCCAACCAC
GCCTCCAGTGTCCCCAGAAGCAAAATACTGACAGTCAGAGTCATTCTTGCCCCATGGAAG
AAAGGACTTATTGCAGTGGTTATCATCGGAGTGATCATTGCTCTCTTGATCATTGCGGCC
AAATGTTATTTTCTGAGGAAAGCCAAGGCCAAGCAGATGCCAGTGGAAATGTCCAGGCCA
GCAGTACCACTTCTGAACTCCAACAACGAGAAAATGTCAGATCCCAATATGGAAGCTAAC
AGTCATTACGGTCACAATGACGATGTCGGAAACCATGCAATGAAACCAATAAATGATAAT
AAAGAGCCTCTGAACTCAGACGTGCAGTACACGGAAGTTCAAGTGTCCTCAGCTGAGTCT
CACAAAGATCTAGGAAAGAAGGACACAGAGACAGTGTACAGTGAAGTCCGGAAAGCTGTC
CCTGATGCCGTGGAAAGCAGATACTCTAGAACGGAAGGCTCCCTTGATGGAACTTAG

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
M37780

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_8_Locus:
17q23

# Macromolecular_Interacting_Partner_8_SNPs:
rs2812; rs2278680; rs6809; rs6808; rs4968723; rs2070782; rs8080825; rs11650554; rs7209590; rs8075386; rs4968619; rs9908930; rs7207019; rs2070783; rs8078363; rs7211356; rs8074422; rs8074738; rs8069023; rs8080232; rs8069746; rs8069177; rs7211869; rs4968620; rs12953; rs8072342; rs7503550; rs5005692; rs4968624; rs6504218; rs1108591; rs8080988; rs4134482; rs7218481; rs1550792; rs8079618; rs4968721; rs6504224; rs4968621; rs8068521; rs7224316; rs4968724; rs8067268; rs1987032; rs7223936; rs9303470; rs4968622; rs1131012; rs7209305; rs11079538; rs7212440; rs7209607; rs12452448; rs9892152; rs6504220; rs8082101; rs12936766; rs954508; rs11652497; rs8066263; rs8076818; rs12948373; rs6504223; rs9908333; rs3934468; rs8065857; rs7225219; rs4968726; rs8081216; rs8065316; rs12941127; rs7220554; rs4072031; rs12944077; rs11871888; rs6504222; rs2018811; rs7503858; rs4968725; rs8073483; rs6504219; rs954507; rs8074241; rs12939215; rs7216012; rs4072032; rs7224431; rs9912957; rs9913080; rs6504221; rs7405936; rs12943471; rs9899806; rs9905219; rs9892243; rs11650625; rs7224140; rs9897797; rs9910953; rs4968727; rs9912788; rs7502663; rs1470453; rs1822954; rs9889838; rs7215755; rs8067406; rs9891246; rs8064990; rs11651357; rs10853052; rs8072145; rs12950916; rs7216986; rs12944065; rs9908803; rs12936832; rs9905235; rs8082096; rs7210508; rs11653092; rs12947510; rs8079084; rs4968729; rs8070522; rs12942699; rs11654022; rs8066583; rs8068012; rs9898528; rs8066504; rs8075099; rs12943015; rs7214356; rs10853053; rs9910666; rs7212459; rs11653990; rs9897901; rs7208509; rs9912195; rs11871707; rs4968730; rs12051786; rs11079537; rs9889944; rs4130374; rs9303469; rs11653087; rs12944400; rs4968728; rs9903171; rs12948665; rs11652639; rs9906431; rs12452560; rs9889983; rs1108592; rs6416939; rs12453662; rs9892298; rs668; rs2070784; rs7213287; rs9748003; rs9902260; rs1050382; rs7214643; rs7213889; rs8076821; rs8182317; rs8182318; rs17072; rs11653341; rs1050352; rs14753; rs13306807; rs35531906; rs11540685; rs28523558; rs35139902; rs34978884; rs35649547; rs10566982; rs35835228; rs28587462; rs33918730; rs12943556; rs34056168; rs28497775; rs7502845; rs8068477; rs11657752; rs12943004; rs35662965; rs35029867; rs28695850; rs34228997; rs28858460; rs12943226; rs10690093; rs8080874; rs10599816; rs11652640; rs5821439; rs28413610; rs10716647; rs28495175; rs34313120; rs9892608; rs35532552; rs11388542; rs11421902; rs7502542; rs5821443; rs5821442; rs9901785; rs10589772; rs11658724; rs13306806; rs2331554; rs7504073; rs2282682; rs5821436; rs6504217; rs7502066; rs35332481; rs35964124; rs11446231; rs28429459; rs35863806; rs34955329; rs34794635; rs34295382; rs11651171; rs10685265; rs28450650; rs12452419; rs5821434; rs34314203; rs8066701; rs4968732; rs4968623; rs10675111; rs34035130; rs35562697; rs28626399; rs11340453; rs11659053; rs5821435; rs11402158; rs7210642; rs34812332; rs36067960; rs7225824; rs35712929; rs34195115; rs28541495; rs13306812; rs34678677; rs10632107; rs35863360; rs7216375; rs12942720; rs12939342; rs7210077; rs34569562; rs11377907; rs11656444; rs9892085; rs34529446; rs12948752; rs28678525; rs35012823; rs9889982; rs8076905; rs36057936; rs36036744; rs28588952; rs8064584; rs7211259; rs34760833; rs6504225; rs8064615; rs28619544; rs10708569; rs13306804; rs4968731; rs7222315; rs12943025; rs34855656; rs28471670; rs35056142; rs5821433; rs35621797; rs10596566; rs34168052; rs35954660; rs28368951; rs12941029; rs34844284; rs11396302; rs7225980; rs28734121; rs10674900; rs11431765; rs35443131; rs4130373; rs34192293; rs12150420; rs34643761; rs35691771; rs35936727; rs7217643; rs11304196; rs8074955; rs28528314; rs11409951; rs34137557; rs9652845; rs5821432; rs35921999; rs9907469; rs8076523; rs34164547; rs34236624; rs8068443; rs12943013; rs10675666; rs9908735; rs34394760; rs34417933; rs12940202; rs35232133; rs34143232; rs35448806; rs35947582; rs11540684; rs28665696; rs11650644; rs12600531; rs5821431; rs11540683; rs34895856; rs35334800; rs7406967; rs1050380; rs11480001; rs41306872; rs13306808; rs34961488; rs41300622; rs35975413; rs1131107; rs41307621; rs1122800; rs12452459; rs12941698; rs12948941; rs12953175; rs7211091; rs8082170; rs9912532

# Macromolecular_Interacting_Partner_8_General_References:
2351935; 1700999; 1690453; 1874786; 7994021; 8226797; 9298995; 12433657; 8532023; 11791967

# Macromolecular_Interacting_Partner_8_References:
15084746; 16151023

# Macromolecular_Interacting_Partner_9_ID:
7934

# Macromolecular_Interacting_Partner_9_Name:
Integrin alpha-11 precursor

# Macromolecular_Interacting_Partner_9_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_9_Gene_Name:
ITGA11

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Integrin alpha11 precursor
MDLPRGLVVAWALSLWPGFTDTFNMDTRKPRVIPGSRTAFFGYTVQQHDISGNKWLVVGA
PLETNGYQKTGDVYKCPVIHGNCTKLNLGRVTLSNVSERKDNMRLGLSLATNPKDNSFLA
CSPLWSHECGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVE
VQHFLINILKKFYIGPGQIQVGVVQYGEDVVHEFHLNDYRSVKDVVEAASHIEQRGGTET
RTAFGIEFARSEAFQKGGRKGAKKVMIVITDGESHDSPDLEKVIQQSERDNVTRYAVAVL
GYYNRRGINPETFLNEIKYIASDPDDKHFFNVTDEAALKDIVDALGDRIFSLEGTNKNET
SFGLEMSQTGFSSHVVEDGVLLGAVGAYDWNGAVLKETSAGKVIPLRESYLKEFPEELKN
HGAYLGYTVTSVVSSRQGRVYVAGAPRFNHTGKVILFTMHNNRSLTIHQAMRGQQIGSYF
GSEITSVDIDGDGVTDVLLVGAPMYFNEGRERGKVYVYELRQNRFVYNGTLKDSHSYQNA
RFGSSIASVRDLNQDSYNDVVVGAPLEDNHAGAIYIFHGFRGSILKTPKQRITASELATG
LQYFGCSIHGQLDLNEDGLIDLAVGALGNAVILWSRPVVQINASLHFEPSKINIFHRDCK
RSGRDATCLAAFLCFTPIFLAPHFQTTTVGIRYNATMDERRYTPRAHLDEGGDRFTNRAV
LLSSGQELCERINFHVLDTADYVKPVTFSVEYSLEDPDHGPMLDDGWPTTLRVSVPFWNG
CNEDEHCVPDLVLDARSDLPTAMEYCQRVLRKPAQDCSAYTLSFDTTVFIIESTRQRVAV
EATLENRGENAYSTVLNISQSANLQFASLIQKEDSDGSIECVNEERRLQKQVCNVSYPFF
RAKAKVAFRLDFEFSKSIFLHHLEIELAAGSDSNERDSTKEDNVAPLRFHLKYEADVLFT
RSSSLSHYEVKLNSSLERYDGIGPPFSCIFRIQNLGLFPIHGIMMKITIPIATRSGNRLL
KLRDFLTDEVANTSCNIWGNSTEYRPTPVEEDLRRAPQLNHSNSDVVSINCNIRLVPNQE
INFHLLGNLWLRSLKALKYKSMKIMVNAALQRQFHSPFIFREEDPSRQIVFEISKQEDWQ
VPIWIIVGSTLGGLLLLALLVLALWKLGFFRSARRRREPGLDPTPKVLE

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
1189

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
133612

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
6.74

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cell-substrate adhesion
Process:  cell-matrix adhesion
Process:  cellular process
Process:  cell adhesion
 ||
>>>
Component:  protein complex
Component:  receptor complex
Component:  integrin complex

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Integrin alpha-11/beta-1 is a receptor for collagen

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF01839:FG-GAP;
PF08441:Integrin_alpha2;
PF00092:VWA

# Macromolecular_Interacting_Partner_9_Signals:
1-22

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
1143-1165

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
6013141

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
ITA11_HUMAN (Q9UKX5)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
ITGA11

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
ITGA11

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:6136

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>3570 bp
ATGGACCTGCCCAGGGGCCTGGTGGTGGCCTGGGCGCTCAGCCTGTGGCCAGGGTTCACG
GACACCTTCAACATGGACACCAGGAAGCCCCGGGTCATCCCTGGCTCCAGGACCGCCTTC
TTTGGCTACACAGTGCAGCAGCACGACATCAGTGGCAATAAGTGGCTGGTCGTGGGCGCC
CCACTGGAAACCAATGGCTACCAGAAGACGGGAGACGTGTACAAGTGTCCAGTGATCCAC
GGGAACTGCACCAAACTCAACCTGGGAAGGGTCACCCTGTCCAACGTGTCCGAGCGGAAA
GACAACATGCGCCTCGGCCTTAGTCTCGCCACCAACCCCAAGGACAACAGCTTCCTGGCC
TGCAGCCCCCTCTGGTCTCATGAGTGTGGGAGCTCCTACTACACCACAGGGATGTGTTCA
AGAGTCAACTCCAACTTCAGGTTCTCCAAGACCGTGGCCCCAGCTCTCCAAAGGTGCCAG
ACCTACATGGACATCGTCATTGTCCTGGATGGCTCCAACAGCATCTACCCCTGGGTGGAG
GTTCAGCACTTCCTCATCAACATCCTGAAAAAGTTTTACATTGGCCCAGGGCAGATCCAG
GTTGGAGTTGTGCAGTATGGCGAAGATGTGGTGCATGAGTTTCACCTCAATGACTACAGG
TCTGTAAAAGATGTGGTGGAAGCTGCCAGCCACATTGAGCAGAGAGGAGGAACAGAGACC
CGGACGGCATTTGGCATTGAATTTGCACGCTCAGAGGCTTTCCAGAAGGGTGGAAGGAAA
GGAGCCAAGAAGGTGATGATTGTCATCACAGATGGGGAGTCCCACGACAGCCCAGACCTG
GAGAAGGTGATCCAGCAAAGCGAAAGAGACAACGTAACAAGATATGCGGTGGCCGTCCTG
GGCTACTACAACCGCAGGGGGATCAATCCAGAAACTTTTCTAAATGAAATCAAATACATC
GCCAGTGACCCTGATGACAAGCACTTCTTCAATGTCACTGATGAGGCTGCCTTGAAGGAC
ATTGTCGATGCCCTGGGGGACAGAATCTTCAGCCTGGAAGGCACCAACAAGAACGAGACC
TCCTTTGGGCTGGAGATGTCACAGACGGGCTTTTCCTCGCACGTGGTGGAGGATGGGGTT
CTGCTGGGAGCCGTCGGTGCCTATGACTGGAATGGAGCTGTGCTAAAGGAGACGAGTGCC
GGGAAGGTCATTCCTCTCCGCGAGTCCTACCTGAAAGAGTTCCCCGAGGAGCTCAAGAAC
CATGGTGCATACCTGGGGTACACAGTCACATCGGTCGTGTCCTCCAGGCAGGGGCGAGTG
TACGTGGCCGGAGCCCCCCGGTTCAACCACACGGGCAAGGTCATCCTGTTCACCATGCAC
AACAACCGGAGCCTCACCATCCACCAGGCTATGCGGGGCCAGCAGATAGGCTCTTACTTT
GGGAGTGAAATCACCTCGGTGGACATCGACGGCGACGGCGTGACTGATGTCCTGCTGGTG
GGCGCACCCATGTACTTCAACGAGGGCCGTGAGCGAGGCAAGGTGTACGTCTATGAGCTG
AGACAGAACCGGTTTGTTTATAACGGAACGCTAAAGGATTCACACAGTTACCAGAATGCC
CGATTTGGGTCCTCCATTGCCTCAGTTCGAGACCTCAACCAGGATTCCTACAATGACGTG
GTGGTGGGAGCCCCCCTGGAGGACAACCACGCAGGAGCCATCTACATCTTCCACGGCTTC
CGAGGCAGCATCCTGAAGACACCTAAGCAGAGAATCACAGCCTCAGAGCTGGCTACCGGC
CTCCAGTATTTTGGCTGCAGCATCCACGGGCAATTGGACCTCAATGAGGATGGGCTCATC
GACCTGGCAGTGGGAGCCCTTGGCAACGCTGTGATTCTGTGGTCCCGCCCAGTGGTTCAG
ATCAATGCCAGCCTCCACTTTGAGCCATCCAAGATCAACATCTTCCACAGAGACTGCAAG
CGCAGTGGCAGGGATGCCACCTGCCTGGCCGCCTTCCTCTGCTTCACGCCCATCTTCCTG
GCACCCCATTTCCAAACAACAACTGTTGGCATCAGATACAACGCCACCATGGATGAGAGG
CGGTATACACCGAGGGCCCACCTGGACGAGGGCGGGGACCGATTCACCAACAGAGCCGTA
CTGCTCTCCTCCGGCCAGGAGCTCTGTGAGCGGATCAACTTCCATGTCCTGGACACTGCT
GACTACGTGAAGCCAGTGACCTTCTCAGTCGAGTATTCCCTGGAGGACCCTGACCATGGC
CCCATGCTGGACGACGGCTGGCCCACCACTCTCAGAGTCTCGGTGCCCTTCTGGAACGGC
TGCAATGAGGATGAGCACTGTGTCCCTGACCTTGTGTTGGATGCCCGGAGTGACCTGCCC
ACGGCCATGGAGTACTGCCAGAGGGTGCTGAGGAAGCCTGCGCAGGACTGCTCCGCATAC
ACGCTGTCCTTCGACACCACAGTCTTCATCATAGAGAGCACACGCCAGCGAGTGGCGGTG
GAGGCCACACTGGAGAACAGGGGCGAGAACGCCTACAGCACGGTCCTAAATATCTCGCAG
TCAGCAAACCTGCAGTTTGCCAGCTTGATCCAGAAGGAGGACTCAGACGGTAGCATTGAG
TGTGTGAACGAGGAGAGGAGGCTCCAGAAGCAAGTCTGCAACGTCAGCTATCCCTTCTTC
CGGGCCAAGGCCAAGGTGGCTTTCCGTCTTGATTTTGAGTTCAGCAAATCCATCTTCCTA
CACCACCTGGAGATCGAGCTCGCTGCAGGCAGTGACAGTAATGAGCGGGACAGCACCAAG
GAAGACAACGTGGCCCCCTTACGCTTCCACCTCAAATACGAGGCTGACGTCCTCTTCACC
AGGAGCAGCAGCCTGAGCCACTACGAGGTCAAGCTCAACAGCTCGCTGGAGAGATACGAT
GGTATCGGGCCTCCCTTCAGCTGCATCTTCAGGATCCAGAACTTGGGCTTGTTCCCCATC
CACGGGATTATGATGAAGATCACCATTCCCATCGCCACCAGGAGCGGCAACCGCCTACTG
AAGCTGAGGGACTTCCTCACGGACGAGGTAGCGAACACGTCCTGTAACATCTGGGGCAAT
AGCACTGAGTACCGGCCCACCCCAGTGGAGGAAGACTTGCGTCGTGCTCCACAGCTGAAT
CACAGCAACTCTGATGTCGTCTCCATCAACTGCAATATACGGCTGGTCCCCAACCAGGAA
ATCAATTTCCATCTACTGGGGAACCTGTGGTTGAGGTCCCTAAAAGCACTCAAGTACAAA
TCCATGAAAATCATGGTCAACGCAGCCTTGCAGAGGCAGTTCCACAGCCCCTTCATCTTC
CGTGAGGAGGATCCCAGCCGCCAGATCGTGTTTGAGATCTCCAAGCAAGAGGACTGGCAG
GTCCCCATCTGGATCATTGTAGGCAGCACCCTGGGGGGCCTCCTACTGCTGGCCCTGCTG
GTCCTGGCACTGTGGAAGCTCGGCTTCTTTAGAAGTGCCAGGCGCAGGAGGGAGCCTGGT
CTGGACCCCACCCCCAAAGTGCTGGAGTGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
AF109681

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:15

# Macromolecular_Interacting_Partner_9_Locus:
15q23

# Macromolecular_Interacting_Partner_9_SNPs:
rs2271725; rs4777035; rs2306022; rs2306024; rs7168069; rs3736493; rs2271724; rs2306023; rs9302249; rs2292745; rs2271728; rs2271720; rs12907890; rs11629460; rs3736494; rs1122247; rs12148843; rs3817330; rs10851784; rs754399; rs898586; rs967565; rs2279101; rs1460644; rs898581; rs8041260; rs11072020; rs7176267; rs4617801; rs8039349; rs3784351; rs12443350; rs4238412; rs8038368; rs8035431; rs8036698; rs11630897; rs7174755; rs1476222; rs3784350; rs898580; rs970264; rs895137; rs11629808; rs750158; rs8035990; rs7170808; rs2306021; rs8040014; rs11635082; rs7170403; rs4776398; rs967566; rs11630977; rs6494735; rs8043127; rs7176011; rs7169854; rs7179228; rs7172210; rs4777049; rs12595773; rs11072015; rs12050670; rs11857985; rs6494736; rs8036939; rs1007617; rs11631030; rs4777033; rs7162189; rs9920271; rs7182849; rs11858032; rs895135; rs11072016; rs1115528; rs4777051; rs11857615; rs4777037; rs3736491; rs898590; rs4777048; rs11632400; rs8024010; rs748892; rs8043152; rs964691; rs4408487; rs9972560; rs5016065; rs11072021; rs11634026; rs12441197; rs1982592; rs4776397; rs12442156; rs4777036; rs898579; rs7176145; rs11855593; rs2415008; rs898584; rs11637286; rs3784345; rs7180218; rs2415001; rs11853855; rs7165618; rs11634100; rs2306012; rs4776402; rs11853718; rs1077731; rs11637293; rs2271723; rs12591673; rs7176173; rs17252387; rs8029230; rs11630284; rs11072010; rs4517737; rs8025985; rs3816612; rs16952065; rs11630928; rs6494743; rs11639240; rs11638575; rs8029838; rs1516871; rs2061564; rs7162991; rs2415000; rs3784346; rs4777041; rs7174916; rs4777046; rs6494732; rs16952005; rs4777039; rs4356422; rs7171871; rs11072014; rs16951961; rs2306013; rs2271722; rs4776404; rs8029113; rs4477640; rs16951767; rs7179347; rs7163918; rs8036876; rs1380881; rs7169899; rs1460645; rs11858758; rs11637346; rs16952001; rs4500670; rs4777034; rs10162690; rs16952059; rs11072011; rs7161791; rs11633421; rs1350733; rs6494742; rs4777040; rs11636019; rs1380883; rs8029162; rs7183704; rs8028967; rs11857338; rs2169213; rs16951778; rs2271721; rs4419008; rs11856183; rs8043262; rs1125721; rs16951774; rs9672310; rs7161871; rs898577; rs2415006; rs11637411; rs8042664; rs748891; rs16951954; rs4238414; rs11072012; rs1075991; rs3736495; rs7497049; rs11858293; rs4776405; rs8041788; rs8042999; rs2415009; rs4776394; rs16952036; rs11633614; rs2415002; rs4776399; rs3784334; rs4777042; rs11635699; rs898582; rs898589; rs6494734; rs1516869; rs3784347; rs7182350; rs2306020; rs2169214; rs11630443; rs10851785; rs7167822; rs2125998; rs16951777; rs2306015; rs11072009; rs7168991; rs2415005; rs4777047; rs16951841; rs8042862; rs898576; rs16952052; rs11072013; rs12595779; rs8028971; rs17318470; rs3784348; rs11634499; rs4776396; rs7168997; rs11852504; rs1824478; rs1020842; rs2306018; rs1813565; rs11635643; rs10851786; rs1319223; rs11072008; rs2414994; rs7164150; rs4375610; rs12440936; rs12592461; rs11637463; rs3784335; rs6494731; rs4776403; rs2306014; rs8030538; rs8030178; rs898593; rs748971; rs10400907; rs7179545; rs16951819; rs895136; rs6494738; rs2306019; rs11636813; rs8042710; rs11855998; rs1380882; rs16951816; rs12591421; rs2306025; rs4777045; rs11856272; rs3784349; rs12914609; rs10851787; rs11634149; rs2306017; rs16951746; rs7164335; rs10444851; rs2415007; rs3784336; rs12441412; rs7179598; rs1020841; rs4776400; rs1077730; rs11858012; rs1563894; rs2305078; rs11632266; rs2415003; rs4536409; rs898575; rs11635776; rs1007615; rs16952041; rs11632656; rs1975874; rs11635712; rs11072018; rs8042332; rs1124577; rs898587; rs8030943; rs1516870; rs2414996; rs7178537; rs2125999; rs4299097; rs2125997; rs6494733; rs17320635; rs16951999; rs7173365; rs16951750; rs2414998; rs967567; rs1841405; rs4777038; rs4777050; rs2306016; rs2899736; rs898583; rs16951765; rs8031003; rs11858671; rs3784342; rs2125996; rs8039820; rs4605110; rs7165305; rs7173815; rs4776395; rs898594; rs1841404; rs11637375; rs16952056; rs898574; rs9783729; rs4454914; rs716379; rs6494740; rs3784344; rs2414997; rs8031936; rs7173564; rs11852717; rs1533469; rs2271726; rs3816611; rs16951835; rs7164172; rs1542473; rs2899735; rs2414995; rs898592; rs7403417; rs7176339; rs12443183; rs8029452; rs17266192; rs11630750; rs7496244; rs7181198; rs7166628; rs898585; rs967564; rs3784337; rs6494744; rs1470415; rs4426302; rs7176148; rs1445024; rs12915814; rs733574; rs3084584; rs12591263; rs34645431; rs28675010; rs1106706; rs28832076; rs12912332; rs28820967; rs34407903; rs28632038; rs33910742; rs34456821; rs1237911; rs4363820; rs11072017; rs2100003; rs1239019; rs16951868; rs35452602; rs4318156; rs28479079; rs35079218; rs8023993; rs11858232; rs34701287; rs8038774; rs28430608; rs28497433; rs34739598; rs35400299; rs11855056; rs10580084; rs12595520; rs11274413; rs7165603; rs10647873; rs4776401; rs9672383; rs8029186; rs35400442; rs34098259; rs2415004; rs34583165; rs28685790; rs11858237; rs11438057; rs28453743; rs4567653; rs1460643; rs28493712; rs28469639; rs34781411; rs5813485; rs10584732; rs10584731; rs34351994; rs35139299; rs35688044; rs5813489; rs12441591; rs8024015; rs35562050; rs13329519; rs34470974; rs35619732; rs3084640; rs34903160; rs34360809; rs34899976; rs28415078; rs33913338; rs5813482; rs34637773; rs11072007; rs8028080; rs11632946; rs35860391; rs4238413; rs35808090; rs8040548; rs28584322; rs7169698; rs28449432; rs898578; rs28620930; rs1077732; rs8028747; rs34800998; rs28517670; rs35874078; rs7164238; rs36078545; rs3084639; rs35280222; rs35325204; rs5813486; rs2271729; rs34438637; rs34704980; rs10574703; rs4777044; rs34297295; rs28669764; rs34222567; rs28695547; rs34278524; rs3084641; rs35584050; rs10618087; rs16952015; rs1542474; rs34822014; rs28740972; rs6494739; rs12591448; rs8032290; rs5813483; rs12898972; rs7174384; rs28442582; rs12902013; rs36216483; rs11858258; rs34660674; rs11632959; rs34338447; rs4777043; rs10565230; rs3837691; rs11858261; rs1824479; rs11854515; rs898591; rs16952019; rs28884935; rs34559605; rs2271727; rs34726895; rs28634234; rs35970041; rs898595; rs11072006; rs34588195; rs12593835; rs28434753; rs10580840; rs28522005; rs8029011; rs16951779; rs6494741; rs34224367; rs34119426; rs12914851; rs12442960; rs11424476; rs11428988; rs28401309; rs12912832; rs2084033; rs34918989; rs35499724; rs12899284; rs7181259; rs28665430; rs35325769; rs6145615; rs34136572; rs28363966; rs11638124; rs28394587; rs34001731; rs1870646; rs34840804; rs5813492; rs5813488; rs35178663; rs2414999; rs28711817; rs9630432; rs28713626; rs1996361; rs35284300; rs11380346; rs16951820; rs33914028; rs28436003; rs5813487; rs4533222; rs35094508; rs35035217; rs3837690; rs12441877; rs28768146; rs34640987; rs35071996; rs35051383; rs28672317; rs34079664; rs28491879; rs11072005; rs28735807; rs28613431; rs12050550; rs3084605; rs28723505; rs9672395; rs12593553; rs35634579; rs11853861; rs35666288; rs10569599; rs35025145; rs35900942; rs28591120; rs34501075; rs11855108; rs12592187; rs36096585; rs3084602; rs16952017; rs28461989; rs28460512; rs35426923; rs35952951; rs28566900; rs10567819; rs4402499; rs34030877; rs34618079; rs5813491; rs7177709; rs898588; rs28404208; rs7174690; rs35904581; rs12593571; rs4517738; rs28480552; rs34220669; rs35455543; rs28592619; rs36112980; rs34122553; rs7177979; rs5813484; rs34788905; rs12908869; rs35563812; rs28683053; rs34467259; rs34009804; rs10444850; rs11072002; rs11072003; rs11072004; rs11072022; rs11072025; rs12438807; rs12442355; rs12593610; rs12593620; rs12593625; rs12593626; rs12593634; rs12594282; rs12595056; rs12899005; rs12904888; rs12906388; rs12913105; rs12913467; rs12913696; rs12914614; rs1373699; rs1445022; rs1445023; rs2415015; rs2415016; rs2415017; rs2415018; rs28452190; rs2899738; rs34702468; rs35906516; rs4280184; rs4410025; rs4999936; rs4999937; rs6494730; rs6494745; rs7162348; rs7163188; rs7167102; rs7167465; rs7168990; rs7172173; rs7172500; rs8043066; rs8043202; rs920922; rs920923; rs920924

# Macromolecular_Interacting_Partner_9_General_References:
10486209; 10464311

# Macromolecular_Interacting_Partner_9_References:
15483378; 16166299

End of HMDB00173

Beginning of HMDB00174
# Accession_No:
HMDB00174

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-07-09 11:43:35

# biospider_lastupdate:
2007-04-18 12:46:33

# Common_Name:
L-Fucose

# Description:
Fucose is a hexose sugar with the chemical formula C6H12O5. It is found on N-linked glycans on the mammalian and plant cell surface. Fucose is secreted in urine when the liver is damaged.  Alpha1->3 linked core fucose is a suspected carbohydrate antigen for IgE-mediated allergy.  Two structural features distinguish fucose from other six-carbon sugars present in mammals: the lack of a hydroxyl group on the carbon at the 6-position (C-6) and the L-configuration. In fucose-containing glycan structures, fucosylated glycans, fucose can exist as a terminal modification or serve as an attachment point for adding other sugars.

# Synonyms:
(-)-Fucose; (-)-L-Fucose; 6-Deoxy-D-galactopyranose; 6-Deoxy-L-beta-galactose; 6-Deoxy-L-galactopyranose; 6-Deoxy-L-galactose; 6-Deoxy-beta-galactose; 6-Desoxygalactose; 6-methyltetrahydropyran-2,3,4,5-tetraol; Fucose; L-(-)-Fucose; L-Fucose; L-Galactomethylose; Rhodeose; 6-Deoxy-delta-galactopyranose

# Chemical_IUPAC_Name:
6-methyloxane-2,3,4,5-tetrol

# Chemical_Formula:
C6H12O5

# Chemical_Structure:
tbl_chemical:::HMDB00174_ZOOM.png:::119283233562513974

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00174_THUMB.png:::119283233398276101

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Carbohydrates

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiacetal; secondary alcohol; 1,2-diol; heterocyclic compound

# Taxonomy_Biofunction:
Component of Fructose and mannose metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
164.06848

# Molecular_Weight_Avg:
164.15649

# Smiles_String_isomeric:
C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O

# Smiles_String_canonical:
CC1OC(O)C(O)C(O)C1O

# KEGG_Compound_ID:
C01019

# BioCyc_ID:
L-FUCOSE

# PubChem_CID:
17106

# PubChem_SID:
4264; 834094; 160301; 841979; 8162809

# OMIM_ID:
230000; 266265

# Metagene_ID:
Not Available

# BiGG_ID:
36636

# Wikipedia_ID:
L-Fucose

# METLIN_ID:
268

# Ref_ID:
9613826; 6184420; 3757018; 9133643; 15082343; 9817848; 15481156; 11692712; 1849114; 10222738; 9842897; 8631761; 15465338; 8364932; 9893952; 16899492; 15774760; 16086588; 11665403; 7762816

# ChEBI_ID:
18287

# CAS_Registry_Number:
2438-80-4

# InChI:
InChI=1/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3+,4+,5-,6?/m0/s1

# Synthesis_Reference:
Validity of Oriental medicines. Part 122. Epimedins A, B and C, flavonoid glycosides of Epimedium koreanum herbs.     Oshima, Yoshiteru; Okamoto, Maki; Hikino, Hiroshi.    Pharm. Inst.,  Tohoku Univ.,  Sendai,  Japan.    Heterocycles  (1987),  26(4),  935

# Melting_Point:
140 oC

# Melting_Point_predicted:
101.3 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
985 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
679.0 mg/mL [MEYLAN,WM et al. (1996)]; 827.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.38 [Predicted by ALOGPS]; -1.4 [Predicted by PubChem via XLOGP]; -1.56 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::L-Fucose.pdf:::1132562211365198108

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::1176921988.mol:::276699197724864

# SDF_File_[Text]:
tbl_chemical:::HMDB00174.sdf:::119283233032995900

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00174.pdb:::119283233260352841

# PDB_ID:
1AH1

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::050118_P00_01_BA_1DP_presat_expanded_2.gif:::114460752039089755

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::050118_P00_01_BA_1DP_presat.zip:::1175124335622343473

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050118_P00_01_BA_1DP_Assigned.png:::117863647177375854

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::050118_P00_01_BA_1DC_104.jpg:::114436641627364461

# C_NMR_FIDS_Spectra:
tbl_cnmr:::050118_P00_01_BA_1DC_104.zip:::114436641633236906

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::050118_P00_01_BA_1DC_104_Assigned.jpg:::116017767135885167

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050118_P00_01_BA_2DHSQC_369.png:::114808253457529272

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050118_P00_01_BA_2DHSQC_369.zip:::114808253458071348

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050118_P00_01_BA_2DHSQC_369_Assigned.png:::116017769729167024

# Predicted_H_NMR_Spectrum:
tbl_chemical:::L-Fucose.gif:::115325150688811408

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00174_peaks.txt:::1156309595886602718

# Predicted_C_NMR_Spectrum:
tbl_chemical:::L-Fucose_C.gif:::115325150691967625

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00174_peaks.txt:::1156310785372373996

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000036.png:::116890823696882979

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000036.txt:::11689082369682802

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000036.png:::116890823671818323

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000036.txt:::116890823696832966

# Cellular_Location:
Cytoplasm; Extracellular; lysosome

# Tissue_Location:
Epidermis; Fibroblasts; Intestine; Kidney; Kidneys; Liver; Myelin; Ovary; Pancreas; Placenta; Skin; Spleen; Testes; Testis

# deuterated:
No

# Biofluid_Location:
Blood; Breast Milk

# Concentration_[Normal]:
Blood	>10	umol/L	Adult:>18_yrs_old	Both	Normal	7762816
Breast_Milk	50.8908566	uM	Adult:>18_yrs_old	Female	Normal	11787731 


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Alcoholic Liver Disease; Alcoholism; Gastric Ulcers; Hypothyroidism; Liver Damage From Cirrhosis

# Pathway_Names:
Fructose and mannose metabolism

# Pathway_Images:
fructose_metabolism.jpg

# KEGG_Images:
map00051

# Pathway_Graphs:
fructose_metabolism_Graph.jpg

# Pathway_SBMLs:
fructose_metabolism.xml

# Metabolic_Enzyme_1_ID:
6157

# Metabolic_Enzyme_1_Name:
Tissue alpha-L-fucosidase precursor

# Metabolic_Enzyme_1_Synonyms:
Alpha-L-fucosidase I; Alpha-L-fucoside fucohydrolase

# Metabolic_Enzyme_1_Gene_Name:
FUCA1

# Metabolic_Enzyme_1_Protein_Sequence:
>Tissue alphaLfucosidase precursor
MRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGVFIHWG
VFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEWADLFQ
AAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKRNIRYGLYHSL
LEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTNF
LSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDKFSWG
YRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKWLSIN
GEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTKITMLG
IQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK

# Metabolic_Enzyme_1_Number_of_Residues:
461

# Metabolic_Enzyme_1_Molecular_Weight:
53176

# Metabolic_Enzyme_1_Theoretical_pI:
6.70

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  fucosidase activity
Function:  alpha-L-fucosidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins

# Metabolic_Enzyme_1_Pathway:
map00511  N-Glycan degradation

# Metabolic_Enzyme_1_Reaction:
an alpha-L-fucoside + H2O = L-fucose + an alcohol

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01120:Alpha_L_fucos

# Metabolic_Enzyme_1_Signals:
1-26

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.2.1.51

# Metabolic_Enzyme_1_GenBank_ID_Protein:
178409

# Metabolic_Enzyme_1_SwissProt_ID:
FUCO_HUMAN (P04066)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
FUCA1

# Metabolic_Enzyme_1_Geneatlas_id:
FUCA1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4006

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_1_Gene_Sequence:
>1386 bp
ATGAGGTCGCGGCCGGCGGGTCCCGCGCTGTTGCTGCTGCTGCTCTTCCTCGGAGCGGCC
GAGTCGGTGCGTCGGGCCCAGCCTCCGCGCCGCTACACCCCAGACTGGCCGAGCCTGGAT
TCTCGGCCGCTGCCGGCCTGGTTCGACGAAGCCAAGTTCGGGGTGTTCATCCACTGGGGC
GTGTTCTCGGTGCCCGCCTGGGGCAGCGAGTGGTTCTGGTGGCACTGGCAGGGCGAGGGG
CGGCCGCAGTACCAGCGCTTCATGCGCGACAACTACCCGCCCGGCTTCAGCTACGCCGAC
TTCGGACCGCAGTTCACTGCGCGCTTCTTCCACCCGGAGGAGTGGGCCGACCTCTTCCAG
GCCGCGGGCGCCAAGTATGTAGTTTTGACGACAAAGCATCACGAAGGCTTCACAAACTGG
CCGAGTCCTGTGTCTTGGAACTGGAACTCCAAAGACGTGGGGCCTCATCGGGATTTGGTT
GGTGAATTGGGAACAGCTCTCCGGAAGAGGAACATCCGCTATGGACTATACCACTCACTC
TTAGAGTGGTTCCATCCACTCTATCTACTTGATAAGAAAAATGGCTTCAAAACACAGCAT
TTTGTCAGTGCAAAAACAATGCCAGAGCTGTACGACCTTGTTAACAGCTATAAACCTGAT
CTGATCTGGTCTGATGGGGAGTGGGAATGTCCTGATACTTACTGGAACTCCACAAATTTT
CTTTCATGGCTCTACAATGACAGCCCTGTCAAGGATGAGGTGGTAGTAAATGACCGATGG
GGTCAGAACTCTTCCTGTCACCATGGAGGATACTATAACTGTGAAGATAAATTCAAGCCA
CAGAGCTTGCCAGATCACAAGTGGGAGATGTGCACCAGCATTGACAAGTTTTCCTGGGGC
TATCGTCGTGACATGGCATTGTCTGATGTTACAGAAGAATCTGAAATCATTTCGGAACTG
GTTCAGACAGTAAGTTTGGGAGGCAACTATCTTCTGAACATTGGACCAACTAAAGATGGA
CTGATTGTTCCCATCTTCCAAGAAAGGCTTCTTGCTGTTGGGAAATGGCTGAGCATCAAT
GGGGAGGCTATCTATGCCTCCAAACCATGGCGGGTGCAATGGGAAAAGAACACAACATCT
GTATGGTATACCTCAAAGGGATCGGCTGTTTATGCCATTTTTCTGCACTGGCCAGAAAAT
GGAGTCTTAAACCTTGAATCCCCCATAACTACCTCAACTACAAAGATAACAATGCTGGGA
ATTCAAGGAGATCTGAAGTGGTCCACAGATCCAGATAAAGGTCTCTTCATCTCTCTACCC
CAGTTGCCACCCTCTGCTGTCCCCGCAGAGTTTGCTTGGACTATAAAGCTGACAGGAGTG
AAGTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M29877

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_1_Locus:
1p34

# Metabolic_Enzyme_1_SNPs:
rs2070956; rs665; rs13551; rs34783036; rs2070955; rs3003621; rs3003328; rs12404321; rs10917431; rs11803575; rs34570472; rs10799804; rs12126122; rs11807558; rs3003332; rs16828757; rs12748109; rs6664538; rs12755062; rs3003320; rs10917430; rs4649119; rs2070954; rs4285654; rs2070953; rs3003622; rs2070952; rs2503003; rs6697825; rs11549096; rs11549095; rs1126512; rs1126847; rs16828754; rs1126689; rs6679838; rs6701072; rs12030587; rs3003329; rs11456086; rs3003325; rs35899950; rs12139061; rs4649122; rs12124188; rs35768557; rs28695769; rs35554549; rs11804092; rs12133557; rs35359105; rs35993651; rs4649120; rs41268125; rs11447446; rs35904775; rs11276026; rs6682044; rs11425085; rs16828763; rs12027988; rs4649121; rs28634031; rs10529609; rs11807370; rs7542696; rs34240712; rs12083336; rs7535480; rs12135166; rs34902309; rs3003333; rs34219363; rs34091972; rs36089665; rs12141409; rs35325250; rs35314193; rs6664030; rs12123591; rs28457240; rs28378447; rs35416130; rs35503930; rs3003321; rs34778255; rs34413067; rs28541960; rs3123554; rs28595294; rs1105; rs1106; rs1130316; rs1130320; rs1130321; rs12737837; rs12744386; rs2229579; rs2229580; rs2229581; rs2229582; rs2229583; rs2229585; rs2229586; rs2501425; rs2501431; rs2501434; rs2502991; rs2502993; rs2503000; rs2503002; rs3003336; rs4649124; rs6663474; rs6665733; rs7553011

# Metabolic_Enzyme_1_General_References:
2803312; 8504303; 2174090; 6096099; 2983333; 2894306; 10094192; 8399358; 7874128; 7815431; 9762612; 12408193

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5487

# Metabolic_Enzyme_2_Name:
L-fucose kinase

# Metabolic_Enzyme_2_Synonyms:
Fucokinase

# Metabolic_Enzyme_2_Gene_Name:
FUK

# Metabolic_Enzyme_2_Protein_Sequence:
>Lfucose kinase
MEQPKGVDWTVIILTCQYKDSVQVFQRELEVRQKREQIPAGTLLLAVEDPEKRVGSGGAT
LNALLVAAEHLSARAGFTVVTSDVLHSAWILILHMGRDFPFDDCGRAFTCLPVENPEAPV
EALVCNLDCLLDIMTYRLGPGSPPGVWVCSTDMLLSVPANPGISWDSFRGARVIALPGSP
AYAQNHGVYLTDPQGLVLDIYYQGTEAEIQRCVRPDGRVPLVSGVVFFSVETAERLLATH
VSPPLDACTYLGLDSGARPVQLSLFFDILHCMAENVTREDFLVGRPPELGQGDADVAGYL
QSARAQLWRELRDQPLTMAYVSSGSYSYMTSSASEFLLSLTLPGAPGAQIVHSQVEEQQL
LAAGSSVVSCLLEGPVQLGPGSVLQHCHLQGPIHIGAGCLVTGLDTAHSKALHGRELRDL
VLQGHHTRLHGSPGHAFTLVGRLDSWERQGAGTYLNVPWSEFFKRTGVRAWDLWDPETLP
AEYCLPSARLFPVLHPSRELGPQDLLWMLDHQEDGGEALRAWRASWRLSWEQLQPCLDRA
ATLASRRDLFFRQALHKARHVLEARQDLSLRPLIWAAVREGCPGPLLATLDQVAAGAGDP
GVAARALACVADVLGCMAEGRGGLRSGPAANPEWMRPFSYLECGDLAAGVEALAQERDKW
LSRPALLVRAARHYEGAGQILIRQAVMSAQHFVSTEQVELPGPGQWVVAECPARVDFSGG
WSDTPPLAYELGGAVLGLAVRVDGRRPIGARARRIPEPELWLAVGPRQDEMTVKIVCRCL
ADLRDYCQPHAPGALLKAAFICAGIVHVHSELQLSEQLLRTFGGGFELHTWSELPHGSGL
GTSSILAGTALAALQRAAGRVVGTEALIHAVLHLEQVLTTGGGWQDQVGGLMPGIKVGRS
RAQLPLKVEVEEVTVPEGFVQKLNDHLLLVYTGKTRLARNLLQDVLRSWYARLPAVVQNA
HSLVRQTEECAEGFRQGSLPLLGQCLTSYWEQKKLMAPGCEPLTVRRMMDVLAPHVHGQS
LAGAGGGGFLYLLTKEPQQKEALEAVLAKTEGLGNYSIHLVEVDTQGLSLKLLGTEASTC
CPFP

# Metabolic_Enzyme_2_Number_of_Residues:
1084

# Metabolic_Enzyme_2_Molecular_Weight:
117624

# Metabolic_Enzyme_2_Theoretical_pI:
6.21

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  phosphorus metabolism
Process:  phosphate metabolism
Process:  phosphorylation
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides

# Metabolic_Enzyme_2_Pathway:
map00051  Fructose and mannose metabolism

# Metabolic_Enzyme_2_Reaction:
ATP + L-fucose = ADP + beta-L-fucose 1-phosphate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF07959:Fucokinase;
PF08544:GHMP_kinases_C;
PF00288:GHMP_kinases_N

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.7.1.52

# Metabolic_Enzyme_2_GenBank_ID_Protein:
21212956

# Metabolic_Enzyme_2_SwissProt_ID:
FUK_HUMAN (Q8N0W3)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
FUK

# Metabolic_Enzyme_2_Geneatlas_id:
FUK

# Metabolic_Enzyme_2_hgnc_id:
HGNC:29500

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>2973 bp
ATGGGTCGAGACTTCCCCTTTGATGACTGTGGCAGGGCTTTCACCTGCCTCCCCGTGGAG
AACCCCGAGGCCCCCGTGGAAGCCTTGGTCTGCAACCTGGACTGCCTGCTGGACATCATG
ACCTATCGGCTGGGCCCGGGCTCCCCGCCAGGCGTGTGGGTCTGCAGCACCGACATGCTG
CTGTCTGTTCCTGCAAATCCTGGTATCAGCTGGGACAGCTTCCGGGGAGCCAGAGTGATC
GCCCTCCCAGGGAGCCCGGCCTACGCTCAGAATCATGGCGTCTACCTAACTGACCCCCAG
GGCCTTGTTTTGGACATTTACTACCAGGGCACTGAGGCAGAGATTCAGCGGTGTGTCAGG
CCTGATGGGCGGGTGCCACTGGTCTCTGGGGTTGTCTTCTTCTCTGTGGAGACTGCCGAG
CGCCTCCTAGCCACCCACGTGAGCCCGCCCCTGGATGCCTGCACCTACCTAGGCTTGGAC
TCCGGAGCCCGGCCTGTCCAGCTGTCTCTGTTTTTTGACATTCTCCACTGCATGGCTGAG
AACGTGACCAGGGAGGACTTCCTGGTGGGGAGGCCCCCAGAGTTGGGGCAAGGCGATGCA
GATGTAGCGGGTTATCTGCAGAGCGCCCGGGCCCAGCTGTGGAGGGAGCTTCGCGATCAG
CCCCTTACCATGGCCTATGTCTCCAGCGGCAGCTACAGCTACATGACCTCCTCAGCCAGT
GAGTTCCTGCTCAGCCTCACACTCCCCGGGGCTCCTGGGGCCCAGATTGTGCACTCCCAG
GTGGAGGAGCAGCAGCTTCTGGCGGCCGGGAGCTCTGTGGTCAGCTGCCTGCTGGAGGGC
CCTGTCCAGCTGGGTCCTGGGAGCGTCCTGCAGCACTGCCACCTGCAGGGCCCCATTCAC
ATAGGCGCTGGCTGCTTGGTGACTGGCCTGGATACAGCCCACTCCAAGGCCCTGCATGGC
CGGGAGCTGCGTGACCTTGTCCTGCAGGGACACCACACGCGGCTACACGGCTCCCCGGGC
CACGCCTTCACCCTCGTTGGCCGTCTGGACAGCTGGGAGAGACAGGGGGCAGGCACATAT
CTCAACGTGCCCTGGAGTGAATTCTTCAAGAGGACAGGTGTTCGAGCCTGGGACCTGTGG
GACCCCGAGACGCTGCCCGCAGAGTACTGCCTTCCCAGCGCCCGCCTCTTTCCTGTGCTC
CACCCCTCGAGGGAGCTGGGACCCCAGGACCTGCTGTGGATGCTGGACCACCAGGAGGAT
GGGGGCGAGGCCCTGCGAGCCTGGCGGGCCTCCTGGCGCCTGTCCTGGGAGCAGCTGCAG
CCGTGCCTGGATCGGGCTGCCACGCTGGCCTCTCGCCGGGACCTGTTCTTCCGCCAGGCC
CTGCATAAGGCGCGGCACGTGCTGGAGGCCCGGCAGGACCTCAGCCTGCGCCCGCTGATC
TGGGCTGCTGTCCGCGAGGGCTGCCCCGGGCCCCTGCTGGCCACGCTGGACCAGGTTGCA
GCTGGGGCAGGAGACCCTGGTGTGGCGGCACGGGCACTGGCCTGTGTGGCGGACGTCCTG
GGCTGCATGGCAGAGGGCCGTGGGGGCTTGCGGAGCGGGCCAGCTGCCAACCCTGAGTGG
ATGCGGCCCTTCTCATACCTGGAGTGTGGAGACCTGGCAGCGGGCGTGGAGGCGCTTGCC
CAGGAGAGGGACAAGTGGCTAAGCAGGCCAGCCTTGCTGGTGCGAGCGGCCCGCCACTAT
GAGGGGGCTGGTCAGATCCTGATCCGCCAGGCTGTGATGTCAGCCCAGCACTTTGTCTCC
ACAGAGCAGGTGGAACTGCCGGGACCTGGGCAGTGGGTGGTGGCTGAGTGCCCGGCCCGT
GTGGATTTCTCTGGGGGCTGGAGTGACACGCCACCCCTTGCCTATGAGCTTGGCGGGGCT
GTGCTGGGCCTGGCTGTGCGAGTGGACGGCCGCCGGCCCATCGGAGCCAGGGCACGCCGC
ATCCCGGAGCCTGAGCTGTGGCTGGCGGTGGGGCCTCGGCAGGATGAGATGACTGTGAAG
ATAGTGTGCCGGTGCCTGGCTGACCTGCGGGACTACTGCCAGCCTCATGCCCCAGGGGCC
CTGCTGAAGGCGGCCTTCATCTGTGCAGGGATCGTGCATGTCCACTCGGAACTCCAGCTG
AGTGAGCAGCTGCTCCGCACCTTCGGGGGCGGCTTTGAGCTGCACACCTGGTCTGAGCTG
CCCCACGGCTCTGGCCTGGGCACCAGCAGCATCCTGGCAGGCACTGCCCTGGCTGCCTTG
CAGCGAGCCGCAGGCCGGGTGGTGGGCACGGAAGCCCTGATCCACGCAGTGCTGCACCTG
GAGCAGGTGCTCACCACTGGAGGTGGCTGGCAGGACCAAGTAGGTGGCCTAATGCCTGGC
ATCAAGGTGGGGCGCTCCCGGGCTCAGCTGCCACTGAAGGTGGAGGTAGAAGAGGTCACG
GTGCCTGAGGGCTTTGTCCAGAAGCTCAATGACCACCTGCTCTTGGTGTACACTGGCAAG
ACCCGCCTGGCTCGGAACCTGCTGCAGGATGTGCTGAGGAGCTGGTATGCCCGACTTCCT
GCTGTGGTGCAGAATGCCCACAGCCTGGTACGGCAAACTGAGGAGTGTGCTGAAGGCTTC
CGCCAAGGAAGCCTGCCTCTGCTGGGCCAGTGCCTGACCTCGTACTGGGAGCAGAAGAAG
CTCATGGCTCCAGGCTGTGAGCCCCTGACTGTGCGGCGTATGATGGATGTCCTGGCCCCC
CACGTGCATGGCCAGAGCCTGGCTGGGGCAGGCGGTGGAGGCTTTCTCTATCTGTTGACC
AAGGAGCCACAGCAAAAGGAGGCCTTGGAGGCGGTGCTGGCCAAGACCGAGGGCCTTGGG
AATTACAGCATCCACCTGGTTGAAGTGGACACTCAGGGCCTGAGCCTGAAGCTGCTGGGG
ACCGAGGCCTCAACCTGTTGCCCTTTCCCATGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AJ441184

# Metabolic_Enzyme_2_Chromosome_Location:
Not Available

# Metabolic_Enzyme_2_Locus:
Not Available

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
12056818

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6158

# Metabolic_Enzyme_3_Name:
Plasma alpha-L-fucosidase precursor

# Metabolic_Enzyme_3_Synonyms:
Alpha-L-fucosidase 2; Alpha-L-fucoside fucohydrolase 2

# Metabolic_Enzyme_3_Gene_Name:
FUCA2

# Metabolic_Enzyme_3_Protein_Sequence:
>Plasma alphaLfucosidase precursor
MRPQELPRLAFPLLLLLLLLLPPPPCPAHSATRFDPTWESLDARQLPAWFDQAKFGIFIH
WGVFSVPSFGSEWFWWYWQKEKIPKYVEFMKDNYPPSFKYEDFGPLFTAKFFNANQWADI
FQASGAKYIVLTSKHHEGFTLWGSEYSWNWNAIDEGPKRDIVKELEVAIRNRTDLRFGLY
YSLFEWFHPLFLEDESSSFHKRQFPVSKTLPELYELVNNYQPEVLWSDGDGGAPDQYWNS
TGFLAWLYNESPVRGTVVTNDRWGAGSICKHGGFYTCSDRYNPGHLLPHKWENCMTIDKL
SWGYRREAGISDYLTIEELVKQLVETVSCGGNLLMNIGPTLDGTISVVFEERLRQVGSWL
KVNGEAIYETYTWRSQNDTVTPDVWYTSKPKEKLVYAIFLKWPTSGQLFLGHPKAILGAT
EVKLLGHGQPLNWISLEQNGIMVELPQLTIHQMPCKWGWALALTNVI

# Metabolic_Enzyme_3_Number_of_Residues:
467

# Metabolic_Enzyme_3_Molecular_Weight:
54061

# Metabolic_Enzyme_3_Theoretical_pI:
6.10

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  fucosidase activity
Function:  alpha-L-fucosidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins

# Metabolic_Enzyme_3_Pathway:
map00511  N-Glycan degradation

# Metabolic_Enzyme_3_Reaction:
an alpha-L-fucoside + H2O = L-fucose + an alcohol

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01120:Alpha_L_fucos

# Metabolic_Enzyme_3_Signals:
1-28

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.2.1.51

# Metabolic_Enzyme_3_GenBank_ID_Protein:
22761559

# Metabolic_Enzyme_3_SwissProt_ID:
FUCO2_HUMAN (Q9BTY2)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
FUCA2

# Metabolic_Enzyme_3_Geneatlas_id:
FUCA2

# Metabolic_Enzyme_3_hgnc_id:
HGNC:4008

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Secreted protein (Probable)

# Metabolic_Enzyme_3_Gene_Sequence:
>1404 bp
ATGCGGCCCCAGGAGCTCCCCAGGCTCGCGTTCCCGTTGCTGCTGTTGCTGTTGCTGCTG
CTGCCGCCGCCGCCGTGCCCTGCCCACAGCGCCACGCGCTTCGACCCCACCTGGGAGTCC
CTGGACGCCCGCCAGCTGCCCGCGTGGTTTGACCAGGCCAAGTTCGGCATCTTCATCCAC
TGGGGAGTGTTTTCCGTGCCCAGCTTCGGTAGCGAGTGGTTCTGGTGGTATTGGCAAAAG
GAAAAGATACCGAAGTATGTGGAATTTATGAAAGATAATTACCCTCCTAGTTTCAAATAT
GAAGATTTTGGACCACTATTTACAGCAAAATTTTTTAATGCCAACCAGTGGGCAGATATT
TTTCAGGCCTCTGGTGCCAAATACATTGTCTTAACTTCCAAACATCATGAAGGCTTTACC
TTGTGGGGGTCAGAATATTCGTGGAACTGGAATGCCATAGATGAGGGGCCCAAGAGGGAC
ATTGTCAAGGAACTTGAGGTAGCCATTAGGAACAGAACTGACCTGCGTTTTGGACTGTAC
TATTCCCTTTTTGAATGGTTTCATCCGCTCTTCCTTGAGGATGAATCCAGTTCATTCCAT
AAGCGGCAATTTCCAGTTTCTAAGACATTGCCAGAGCTCTATGAGTTAGTGAACAACTAT
CAGCCTGAGGTTCTGTGGTCGGATGGTGACGGAGGAGCACCGGATCAATACTGGAACAGC
ACAGGCTTCTTGGCCTGGTTATATAATGAAAGCCCAGTTCGGGGCACAGTAGTCACCAAT
GATCGTTGGGGAGCTGGTAGCATCTGTAAGCATGGTGGCTTCTATACCTGCAGTGATCGT
TATAACCCAGGACATCTTTTGCCACATAAATGGGAAAACTGCATGACAATAGACAAACTG
TCCTGGGGCTATAGGAGGGAAGCTGGAATCTCTGACTATCTTACAATTGAAGAATTGGTG
AAGCAACTTGTAGAGACAGTTTCATGTGGAGGAAATCTTTTGATGAATATTGGGCCCACA
CTAGATGGCACCATTTCTGTAGTTTTTGAGGAGCGACTGAGGCAAGTGGGGTCCTGGCTA
AAAGTCAATGGAGAAGCTATTTATGAAACCTATACCTGGCGATCCCAGAACGACACTGTC
ACCCCAGATGTGTGGTACACATCCAAGCCTAAAGAAAAATTAGTCTATGCCATTTTTCCT
AAATGGCCCACATCAGGACAGCTGTTCCTTGGCCATCCCAAAGCTATTCTGGGGGCAACA
GAGGTGAAACTACTGGGCCATGGACAGCCACTTAACTGGATTTCTTTGGAGCAAAATGGC
ATTATGGTAGAACTGCCACAGCTAACCATTCATCAGATGCCGTGTAAATGGGGCTGGGCT
CTAGCCCTAACTAATGTGATCTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
AK075458

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_3_Locus:
6q24

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
12975309; 14574404

# Metabolic_Enzyme_3_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7555

# Macromolecular_Interacting_Partner_1_Name:
Fibronectin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
FN; Cold-insoluble globulin; CIG

# Macromolecular_Interacting_Partner_1_Gene_Name:
FN1

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Fibronectin precursor
MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQ
INQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMI
WDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCK
PIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSY
RIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHP
QPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPC
VLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTQGGNSNGALC
HFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRI
GDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHM
LNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQ
PLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIP
GHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSP
LVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDL
LPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITG
YRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTG
TPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNT
FAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWTPP
RAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATG
VFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVV
SGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTVSWERSTT
PDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPIS
DTIIPAVPPPTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSD
NAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIA
PRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLL
IGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSK
STATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISV
KWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGE
SQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAP
DGEEDTAELQGLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTDLKFTQVTPTSLSA
QWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLT
SRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANGQTPIQRT
IKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDASTAIDAPSNLRFLATTPNSLL
VSWQPPRARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ
KSEPLIGRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFVTHPGYDTGNGIQLPGTS
GQQPSVGQQMIFEEHGFRRTTPPTTATPIRHRPRPYPPNVGEEIQIGHIPREDVDYHLYP
HGPGLNPNASTGQEALSQTTISWAPFQDTSEYIISCHPVGTDEEPLQFRVPGTSTSATLT
GLTRGATYNIIVEALKDQQRHKVREEVVTVGNSVNEGLNQPTDDSCFDPYTVSHYAVGDE
WERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQMMSCTCLG
NGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGGEP
SPEGTTGQSYNQYSQRYHQRTNTNVNCPIECFMPLDVQADREDSRE

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
2386

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
262609

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.42

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00039:fn1;
PF00040:fn2;
PF00041:fn3

# Macromolecular_Interacting_Partner_1_Signals:
1-31

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
12053817

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
FINC_HUMAN (P02751)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
FN1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
FN1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:3778

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein; extracellular space; extracellular matrix

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1929 bp
ATGCTTAGGGGTCCGGGGCCCGGGCTGCTGCTGCTGGCCGTCCAGTGCCTGGGGACAGCG
GTGCCCTCCACGGGAGCCTCGAAGAGCAAGAGGCAGGCTCAGCAAATGGTTCAGCCCCAG
TCCCCGGTGGCTGTCAGTCAAAGCAAGCCCGGTTGTTATGACAATGGAAAACACTATCAG
ATAAATCAACAGTGGGAGCGGACCTACCTAGGCAATGCGTTGGTTTGTACTTGTTATGGA
GGAAGCCGAGGTTTTAACTGCGAGAGTAAACCTGAAGCTGAAGAGACTTGCTTTGACAAG
TACACTGGGAACACTTACCGAGTGGGTGACACTTATGAGCGTCCTAAAGACTCCATGATC
TGGGACTGTACCTGCATCGGGGCTGGGCGAGGGAGAATAAGCTGTACCATCGCAAACCGC
TGCCATGAAGGGGGTCAGTCCTACAAGATTGGTGACACCTGGAGGAGACCACATGAGACT
GGTGGTTACATGTTAGAGTGTGTGTGTCTTGGTAATGGAAAAGGAGAATGGACCTGCAAG
CCCATAGCTGAGAAGTGTTTTGATCATGCTGCTGGGACTTCCTATGTGGTCGGAGAAACG
TGGGAGAAGCCCTACCAAGGCTGGATGATGGTAGATTGTACTTGCCTGGGAGAAGGCAGC
GGACGCATCACTTGCACTTCTAGAAATAGATGCAACGATCAGGACACAAGGACATCCTAT
AGAATTGGAGACACCTGGAGCAAGAAGGATAATCGAGGAAACCTGCTCCAGTGCATCTGC
ACAGGCAACGGCCGAGGAGAGTGGAAGTGTGAGAGGCACACCTCTGTGCAGACCACATCG
AGCGGATCTGGCCCCTTCACCGATGTTCGTGCAGCTGTTTACCAACCGCAGCCTCACCCC
CAGCCTCCTCCCTATGGCCACTGTGTCACAGACAGTGGTGTGGTCTACTCTGTGGGGATG
CAGTGGCTGAAGACACAAGGAAATAAGCAAATGCTTTGCACGTGCCTGGGCAACGGAGTC
AGCTGCCAAGAGACAGCTGTAACCCAGACTTACGGTGGCAACTCAAATGGAGAGCCATGT
GTCTTACCATTCACCTACAACGACAGGACGGACAGCACAACTTCGAATTATGAGCAGGAC
CAGAAATACTCTTTCTGCACAGACCACACTGTTTTGGTTCAGACTCGAGGAGGAAATTCC
AATGGTGCCTTGTGCCACTTCCCCTTCCTATACAACAACCACAATTACACTGATTGCACT
TCTGAGGGCAGAAGAGACAACATGAAGTGGTGTGGGACCACACAGAACTATGATGCCGAC
CAGAAGTTTGGGTTCTGCCCCATGGCTGCCCACGAGGAAATCTGCACAACCAATGAAGGG
GTCATGTACCGCATTGGAGATCAGTGGGATAAGCAGCATGACATGGGTCACATGATGAGG
TGCACGTGTGTTGGGAATGGTCGTGGGGAATGGACATGCATTGCCTACTCGCAGCTTCGA
GATCAGTGCATTGTTGATGACATCACTTACAATGTGAACGACACATTCCACAAGCGTCAT
GAAGAGGGGCACATGCTGAACTGTACATGCTTCGGTCAGGGTCGGGGCAGGTGGAAGTGT
GATCCCGTCGACCAATGCCAGGATTCAGAGACTGGGACGTTTTATCAAATTGGAGATTCA
TGGGAGAAGTATGTGCATGGTGTCAGATACCAGTGCTACTGCTATGGCCGTGGCATTGGG
GAGTGGCATTGCCAACCTTTACAGACCTATCCAAGCTCAAGTGGTCCTGTCGAAGTATTT
ATCACTGAGACTCCGAGTCAGCCCAACTCCCACCCCATCCAGTGGAATGCACCACAGCCA
TCTCACATTTCCAAGTACATTCTCAGGTGGAGACCTGTGAGTATCCCACCCAGAAACCTT
GGATACTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AJ276395

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_1_Locus:
2q34

# Macromolecular_Interacting_Partner_1_SNPs:
rs6728999; rs17449032; rs1250259; rs1053238; rs7584505; rs13652; rs7596677; rs2289202; rs7589580; rs11651; rs34923683; rs1263; rs1264; rs1250215; rs1250270; rs2289199; rs1250249; rs2692228; rs1250250; rs1250238; rs724617; rs2888354; rs1250248; rs1250240; rs940739; rs1250239; rs1250241; rs1561301; rs1250210; rs1250269; rs7575234; rs1250268; rs7586990; rs10202483; rs10804242; rs7557114; rs7570208; rs1250203; rs1437799; rs2577290; rs7609476; rs6707530; rs10199059; rs1250242; rs2577297; rs1525351; rs7560662; rs6725958; rs2692230; rs7588661; rs1347694; rs7349218; rs2577302; rs1968510; rs12615520; rs10932613; rs6435906; rs1561302; rs13021377; rs6435903; rs7574485; rs6731557; rs1866155; rs1437798; rs1250204; rs6744921; rs7588830; rs10207245; rs7608342; rs2304573; rs7567647; rs4622720; rs6734955; rs1837121; rs2462591; rs13423742; rs3213885; rs13018173; rs13306359; rs2692234; rs10498037; rs7568287; rs1250247; rs1250245; rs940740; rs13432972; rs1975319; rs17517509; rs9288508; rs7560554; rs1250213; rs12466925; rs1898536; rs2577289; rs1437797; rs2289200; rs7594168; rs17457002; rs10172425; rs1250244; rs1437795; rs3796123; rs6709607; rs13004592; rs12105173; rs11693652; rs7575551; rs6435905; rs10498038; rs17457252; rs2372544; rs10201850; rs1250214; rs9288507; rs1250246; rs940738; rs11883812; rs7598634; rs17516906; rs2289198; rs13431081; rs1250258; rs1250201; rs17456939; rs2372545; rs4328631; rs1250243; rs1437796; rs13020766; rs2692224; rs13414859; rs1370561; rs12694363; rs2577298; rs10185587; rs17457029; rs1525352; rs1250211; rs17457391; rs11687442; rs12468524; rs17456054; rs3732355; rs2372542; rs17458018; rs16854055; rs10179882; rs6435904; rs16854041; rs13306373; rs13306365; rs7422428; rs10804241; rs11674123; rs3214671; rs2692223; rs13416478; rs16853839; rs7572169; rs1250212; rs7579867; rs13385786; rs2692227; rs1250256; rs10188325; rs7562453; rs13021679; rs1968509; rs6728950; rs7580800; rs12991003; rs11897708; rs12472383; rs6716361; rs1250264; rs17517928; rs34255697; rs7592898; rs33996776; rs1250267; rs6729052; rs17515300; rs7595740; rs7598545; rs12464459; rs2692222; rs11690611; rs16853986; rs7580569; rs13306364; rs11687611; rs1058361; rs1250209; rs13306372; rs34043251; rs2577301; rs28379061; rs11544109; rs2118413; rs11544105; rs34174607; rs11544106; rs6782; rs35223740; rs35151953; rs35525385; rs2692226; rs35343655; rs13394662; rs34228975; rs10605109; rs10170514; rs34300660; rs13008516; rs35292159; rs28464508; rs35819982; rs34685276; rs35762962; rs17514904; rs35800609; rs1063272; rs2028203; rs1250205; rs11367419; rs5838505; rs35913187; rs34978418; rs1250207; rs7556711; rs2438174; rs36086086; rs7422768; rs10203450; rs7598615; rs10599440; rs35126158; rs5838506; rs5838509; rs36097152; rs28564011; rs10181380; rs5838513; rs16853904; rs9749692; rs6743670; rs41347752; rs9751656; rs13026921; rs35976930; rs35034272; rs10534431; rs34066120; rs34085634; rs34576780; rs13017248; rs10648691; rs5838511; rs1250266; rs1968508; rs1250257; rs10542238; rs10559309; rs11897227; rs1250251; rs34656990; rs2577300; rs13306367; rs10168572; rs13394972; rs3832178; rs34162130; rs11889491; rs35639338; rs2372541; rs28631799; rs34087019; rs34317431; rs35609230; rs34325359; rs7606467; rs10179937; rs10202709; rs34595854; rs35492653; rs34345666; rs35754566; rs9751659; rs35780063; rs5838503; rs13431830; rs1313044; rs6729046; rs6727989; rs35233997; rs34645626; rs7565821; rs10524797; rs5838512; rs2438173; rs36098055; rs34156003; rs1250208; rs35545936; rs5838504; rs10648148; rs1250216; rs11411384; rs11376297; rs36066561; rs1250206; rs1250263; rs7556883; rs3051917; rs1250265; rs35437250; rs35258787; rs10679143; rs7558917; rs13306371; rs12621043; rs4393746; rs35494414; rs16853944; rs34173232; rs34314527; rs5838507; rs11358448; rs2177736; rs34245778; rs10649966; rs10614770; rs2577296; rs34947596; rs10577918; rs9751655; rs33963377; rs13306368; rs16853844; rs16853861; rs34147750; rs2372543; rs11315848; rs5838508; rs11350861; rs1437794; rs35440741; rs6712858; rs5838515; rs5838501; rs11897252; rs34140794; rs13427569; rs13015576; rs5838510; rs35967269; rs35143823; rs2289201; rs34196672; rs10611390; rs13001466; rs6738126; rs7562601; rs13409661; rs6738148; rs5838516; rs13023606; rs10599084; rs28365987; rs35118035; rs10180997; rs1250227; rs1250228; rs1250229; rs1250230; rs1250232; rs1250233; rs1250234; rs1250235; rs1250237; rs12999909; rs13027307; rs2577292; rs2692225; rs3910516; rs4473378; rs6706415; rs6725921; rs6735789; rs7562597; rs7588799; rs7596482; rs7604984

# Macromolecular_Interacting_Partner_1_General_References:
11737888; 3770189; 3031656; 2992939; 3900070; 6462919; 3375063; 2822387; 3478690; 7050098; 6688418; 3003095; 3593230; 2992573; 6200322; 3021206; 12127832; 2989004; 3770201; 4019516; 6304699; 6630202; 3024962; 2414772; 2012601; 1400330; 7989369; 9501082; 1311202; 1423622; 8308892; 7583666; 9514732; 10196121; 10647176; 11285216; 11775745; 12736686; 8120888; 8548820; 10075919

# Macromolecular_Interacting_Partner_1_References:
10780667; 15236335; 15651048

# Macromolecular_Interacting_Partner_2_ID:
7556

# Macromolecular_Interacting_Partner_2_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_2_Signals:
1-18

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_2_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_2_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_2_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_2_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_2_References:
10581158; 12096741; 14576172; 9514576

# Macromolecular_Interacting_Partner_3_ID:
7610

# Macromolecular_Interacting_Partner_3_Name:
Matrix metalloproteinase-9 precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
MMP-9; 92 kDa type IV collagenase; 92 kDa gelatinase; Gelatinase B; GELB[Contains: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]

# Macromolecular_Interacting_Partner_3_Gene_Name:
MMP9

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Matrix metalloproteinase9 precursor
MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEM
RGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHN
ITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYP
FDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRS
YSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTRDGNADGKPCQFPFIFQGQSYS
ACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYST
CTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMY
PMYRFTEGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSER
PTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYW
RFSEGRGSRPQGPFLIADKWPALPRKLDSVFEEPLSKKLFFFSGRQVWVYTGASVLGPRR
LDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLD
THDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPED

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
707

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
78428

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
5.92

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  metallopeptidase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  metalloendopeptidase activity
 ||
>>>
Process:  carbohydrate metabolism
Process:  cellular carbohydrate metabolism
Process:  peptidoglycan metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  extracellular matrix
Component:  extracellular matrix (sensu Metazoa)

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Cleavage of gelatin types I and V and collagen types IV and V

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00040:fn2;
PF00045:Hemopexin;
PF00413:Peptidase_M10;
PF01471:PG_binding_1;
PF04886:PT

# Macromolecular_Interacting_Partner_3_Signals:
1-19

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
EC 3.4.24.35

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
177205

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
MMP9_HUMAN (P14780)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
MMP9

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
MMP9

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:7176

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>2124 bp
ATGAGCCTCTGGCAGCCCCTGGTCCTGGTGCTCCTGGTGCTGGGCTGCTGCTTTGCTGCC
CCCAGACAGCGCCAGTCCACCCTTGTGCTCTTCCCTGGAGACCTGAGAACCAATCTCACC
GACAGGCAGCTGGCAGAGGAATACCTGTACCGCTATGGTTACACTCGGGTGGCAGAGATG
CGTGGAGAGTCGAAATCTCTGGGGCCTGCGCTGCTGCTTCTCCAGAAGCAACTGTCCCTG
CCCGAGACCGGTGAGCTGGATAGCGCCACGCTGAAGGCCATGCGAACCCCACGGTGCGGG
GTCCCAGACCTGGGCAGATTCCAAACCTTTGAGGGCGACCTCAAGTGGCACCACCACAAC
ATCACCTATTGGATCCAAAACTACTCGGAAGACTTGCCGCGGGCGGTGATTGACGACGCC
TTTGCCCGCGCCTTCGCACTGTGGAGCGCGGTGACGCCGCTCACCTTCACTCGCGTGTAC
AGCCGGGACGCAGACATCGTCATCCAGTTTGGTGTCGCGGAGCACGGAGACGGGTATCCC
TTCGACGGGAAGGACGGGCTCCTGGCACACGCCTTTCCTCCTGGCCCCGGCATTCAGGGA
GACGCCCATTTCGACGATGACGAGTTGTGGTCCCTGGGCAAGGGCGTCGTGGTTCCAACT
CGGTTTGGAAACGCAGATGGCGCGGCCTGCCACTTCCCCTTCATCTTCGAGGGCCGCTCC
TACTCTGCCTGCACCACCGACGGTCGCTCCGACGGCTTGCCCTGGTGCAGTACCACGGCC
AACTACGACACCGACGACCGGTTTGGCTTCTGCCCCAGCGAGAGACTCTACACCCGGGAC
GGCAATGCTGATGGGAAACCCTGCCAGTTTCCATTCATCTTCCAAGGCCAATCCTACTCC
GCCTGCACCACGGACGGTCGCTCCGACGGCTACCGCTGGTGCGCCACCACCGCCAACTAC
GACCGGGACAAGCTCTTCGGCTTCTGCCCGACCCGAGCTGACTCGACGGTGATGGGGGGC
AACTCGGCGGGGGAGCTGTGCGTCTTCCCCTTCACTTTCCTGGGTAAGGAGTACTCGACC
TGTACCAGCGAGGGCCGCGGAGATGGGCGCCTCTGGTGCGCTACCACCTCGAACTTTGAC
AGCGACAAGAAGTGGGGCTTCTGCCCGGACCAAGGATACAGTTTGTTCCTCGTGGCGGCG
CATGAGTTCGGCCACGCGCTGGGCTTAGATCATTCCTCAGTGCCGGAGGCGCTCATGTAC
CCTATGTACCGCTTCACTGAGGGGCCCCCCTTGCATAAGGACGACGTGAATGGCATCCGG
CACCTCTATGGTCCTCGCCCTGAACCTGAGCCACGGCCTCCAACCACCACCACACCGCAG
CCCACGGCTCCCCCGACGGTCTGCCCCACCGGACCCCCCACTGTCCACCCCTCAGAGCGC
CCCACAGCTGGCCCCACAGGTCCCCCCTCAGCTGGCCCCACAGGTCCCCCCACTGCTGGC
CCTTCTACGGCCACTACTGTGCCTTTGAGTCCGGTGGACGATGCCTGCAACGTGAACATC
TTCGACGCCATCGCGGAGATTGGGAACCAGCTGTATTTGTTCAAGGATGGGAAGTACTGG
CGATTCTCTGAGGGCAGGGGGAGCCGGCCGCAGGGCCCCTTCCTTATCGCCGACAAGTGG
CCCGCGCTGCCCCGCAAGCTGGACTCGGTCTTTGAGGAGCCGCTCTCCAAGAAGCTTTTC
TTCTTCTCTGGGCGCCAGGTGTGGGTGTACACAGGCGCGTCGGTGCTGGGCCCGAGGCGT
CTGGACAAGCTGGGCCTGGGAGCCGACGTGGCCCAGGTGACCGGGGCCCTCCGGAGTGGC
AGGGGGAAGATGCTGCTGTTCAGCGGGCGGCGCCTCTGGAGGTTCGACGTGAAGGCGCAG
ATGGTGGATCCCCGGAGCGCCAGCGAGGTGGACCGGATGTTCCCCGGGGTGCCTTTGGAC
ACGCACGACGTCTTCCAGTACCGAGAGAAAGCCTATTTCTGCCAGGACCGCTTCTACTGG
CGCGTGAGTTCCCGGAGTGAGTTGAACCAGGTGGACCAAGTGGGCTACGTGACCTATGAC
ATCCTGCAGTGCCCTGAGGACTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
J05070

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_3_Locus:
20q11.2-q13.1

# Macromolecular_Interacting_Partner_3_SNPs:
rs2250889; rs3918252; rs2274756; rs25650; rs41427445; rs35691798; rs1805088; rs17576; rs13969; rs13925; rs9509; rs20544; rs2274755; rs3918249; rs3918256; rs3918251; rs3918254; rs3787268; rs3918259; rs3918262; rs3838026; rs28763887; rs3918253; rs3918261; rs3918266; rs3918267; rs3918255; rs2236416; rs6104425; rs3918281; rs3918263; rs3918260; rs3918245; rs3918240; rs3918278; rs3918270; rs3918242; rs3918272; rs3918273; rs3918241; rs3918271; rs6017724; rs34922724; rs3918280; rs34016235; rs41529445; rs8125581; rs6104428; rs1805089; rs6032623; rs28763886; rs6017725; rs6104427; rs1802909; rs28763885; rs41426845; rs1056628; rs1802908; rs2664517; rs6130996; rs41504450; rs6104424; rs3918282; rs35219792; rs8125587; rs6130995; rs11473837; rs41410049; rs6073987; rs6017726; rs13040580; rs3918258; rs6032624; rs3918264; rs6130994; rs3918257; rs34061937; rs6104423; rs6130993; rs34433634; rs3918265; rs6104426; rs41347245; rs10631124; rs35862772; rs6073988; rs13040572; rs3918250; rs35029798; rs3080277; rs4578914; rs3918243; rs3918247; rs6130992; rs3918246; rs6104422; rs11476145; rs3918268; rs35187515; rs11483049; rs41402549; rs8184490; rs3918279; rs3918269; rs3918283; rs3918244; rs35573488; rs34003985; rs36040399; rs10211842; rs11696804; rs11697325; rs12481671; rs3848721; rs3848722; rs3933239; rs4810482; rs6032620; rs6032625; rs6065912; rs6065913; rs6073983; rs6073990; rs6094235; rs6094236; rs6094237; rs6104416; rs6104419; rs6104420; rs6104421; rs6104432; rs6130988; rs6130989; rs6130998; rs8113877

# Macromolecular_Interacting_Partner_3_General_References:
2551898; 1653238; 11780052; 8426746; 1653055; 1371271; 7669817; 1645657; 1932376; 12879005; 10598806

# Macromolecular_Interacting_Partner_3_References:
12199626; 16286790

# Macromolecular_Interacting_Partner_4_ID:
7932

# Macromolecular_Interacting_Partner_4_Name:
Pro-epidermal growth factor precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
EGF[Contains: Epidermal growth factor; Urogastrone]

# Macromolecular_Interacting_Partner_4_Gene_Name:
EGF

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Proepidermal growth factor precursor
MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRID
TEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSG
MAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAG
SLYRADLDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHI
SKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHP
LAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNEC
AFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPL
CFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASG
PQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERAN
MDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQP
RGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCD
AKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVR
LQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC
LALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGC
SMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCS
EGYQGDGIHCLDIDECQLGVHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHL
REDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWW
ELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRS
RRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGM
GTEQGCWIPVSSDKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPP
HQMELTQ

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
1207

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
133947

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
5.74

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00008:EGF;
PF07645:EGF_CA;
PF00058:Ldl_recept_b

# Macromolecular_Interacting_Partner_4_Signals:
1-22

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
1033-1053

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
31121

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
EGF_HUMAN (P01133)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
EGF

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
EGF

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:3229

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>3624 bp
ATGCTGCTCACTCTTATCATTCTGTTGCCAGTAGTTTCAAAATTTAGTTTTGTTAGTCTC
TCAGCACCGCAGCACTGGAGCTGTCCTGAAGGTACTCTCGCAGGAAATGGGAATTCTACT
TGTGTGGGTCCTGCACCCTTCTTAATTTTCTCCCATGGAAATAGTATCTTTAGGATTGAC
ACAGAAGGAACCAATTATGAGCAATTGGTGGTGGATGCTGGTGTCTCAGTGATCATGGAT
TTTCATTATAATGAGAAAAGAATCTATTGGGTGGATTTAGAAAGACAACTTTTGCAAAGA
GTTTTTCTGAATGGGTCAAGGCAAGAGAGAGTATGTAATATAGAGAAAAATGTTTCTGGA
ATGGCAATAAATTGGATAAATGAAGAAGTTATTTGGTCAAATCAACAGGAAGGAATCATT
ACAGTAACAGATATGAAAGGAAATAATTCCCACATTCTTTTAAGTGCTTTAAAATATCCT
GCAAATGTAGCAGTTGATCCAGTAGAAAGGTTTATATTTTGGTCTTCAGAGGTGGCTGGA
AGCCTTTATAGAGCAGATCTCGATGGTGTGGGAGTGAAGGCTCTGTTGGAGACATCAGAG
AAAATAACAGCTGTGTCATTGGATGTGCTTGATAAGCGGCTGTTTTGGATTCAGTACAAC
AGAGAAGGAAGCAATTCTCTTATTTGCTCCTGTGATTATGATGGAGGTTCTGTCCACATT
AGTAAACATCCAACACAGCATAATTTGTTTGCAATGTCCCTTTTTGGTGACCGTATCTTC
TATTCAACATGGAAAATGAAGACAATTTGGATAGCCAACAAACACACTGGAAAGGACATG
GTTAGAATTAACCTCCATTCATCATTTGTACCACTTGGTGAACTGAAAGTAGTGCATCCA
CTTGCACAACCCAAGGCAGAAGATGACACTTGGGAGCCTGAGCAGAAACTTTGCAAATTG
AGGAAAGGAAACTGCAGCAGCACTGTGTGTGGGCAAGACCTCCAGTCACACTTGTGCATG
TGTGCAGAGGGATACGCCCTAAGTCGAGACCGGAAGTACTGTGAAGATGTTAATGAATGT
GCTTTTTGGAATCATGGCTGTACTCTTGGGTGTAAAAACACCCCTGGATCCTATTACTGC
ACGTGCCCTGTAGGATTTGTTCTGCTTCCTGATGGGAAACGATGTCATCAACTTGTTTCC
TGTCCACGCAATGTGTCTGAATGCAGCCATGACTGTGTTCTGACATCAGAAGGTCCCTTA
TGTTTCTGTCCTGAAGGCTCAGTGCTTGAGAGAGATGGGAAAACATGTAGCGGTTGTTCC
TCACCCGATAATGGTGGATGTAGCCAGCTCTGCGTTCCTCTTAGCCCAGTATCCTGGGAA
TGTGATTGCTTTCCTGGGTATGACCTACAACTGGATGAAAAAAGCTGTGCAGCTTCAGGA
CCACAACCATTTTTGCTGTTTGCCAATTCTCAAGATATTCGACACATGCATTTTGATGGA
ACAGACTATGGAACTCTGCTCAGCCAGCAGATGGGAATGGTTTATGCCCTAGATCATGAC
CCTGTGGAAAATAAGATATACTTTGCCCATACAGCCCTGAAGTGGATAGAGAGAGCTAAT
ATGGATGGTTCCCAGCGAGAAAGGCTTATTGAGGAAGGAGTAGATGTGCCAGAAGGTCTT
GCTGTGGACTGGATTGGCCGTAGATTCTATTGGACAGACAGAGGGAAATCTCTGATTGGA
AGGAGTGATTTAAATGGGAAACGTTCCAAAATAATCACTAAGGAGAACATCTCTCAACCA
CGAGGAATTGCTGTTCATCCAATGGCCAAGAGATTATTCTGGACTGATACAGGGATTAAT
CCACGAATTGAAAGTTCTTCCCTCCAAGGCCTTGGCCGTCTGGTTATAGCCAGCTCTGAT
CTAATCTGGCCCAGTGGAATAACGATTGACTTCTTAACTGACAAGTTGTACTGGTGCGAT
GCCAAGCAGTCTGTGATTGAAATGGCCAATCTGGATGGTTCAAAACGCCGAAGACTTACC
CAGAATGATGTAGGTCACCCATTTGCTGTAGCAGTGTTTGAGGATTATGTGTGGTTCTCA
GATTGGGCTATGCCATCAGTAATAAGAGTAAACAAGAGGACTGGCAAAGATAGAGTACGT
CTCCAAGGCAGCATGCTGAAGCCCTCATCACTGGTTGTGGTTCATCCATTGGCAAAACCA
GGAGCAGATCCCTGCTTATATCAAAACGGAGGCTGTGAACATATTTGCAAAAAGAGGCTT
GGAACTGCTTGGTGTTCGTGTCGTGAAGGTTTTATGAAAGCCTCAGATGGGAAAACGTGT
CTGGCTCTGGATGGTCATCAGCTGTTGGCAGGTGGTGAAGTTGATCTAAAGAACCAAGTA
ACACCATTGGACATCTTGTCCAAGACTAGAGTGTCAGAAGATAACATTACAGAATCTCAA
CACATGCTAGTGGCTGAAATCATGGTGTCAGATCAAGATGACTGTGCTCCTGTGGGATGC
AGCATGTATGCTCGGTGTATTTCAGAGGGAGAGGATGCCACATGTCAGTGTTTGAAAGGA
TTTGCTGGGGATGGAAAACTATGTTCTGATATAGATGAATGTGAGATGGGTGTCCCAGTG
TGCCCCCCTGCCTCCTCCAAGTGCATCAACACCGAAGGTGGTTATGTCTGCCGGTGCTCA
GAAGGCTACCAAGGAGATGGGATTCACTGTCTTGATATTGATGAGTGCCAACTGGGGGTG
CACAGCTGTGGAGAGAATGCCAGCTGCACAAATACAGAGGGAGGCTATACCTGCATGTGT
GCTGGACGCCTGTCTGAACCAGGACTGATTTGCCCTGACTCTACTCCACCCCCTCACCTC
AGGGAAGATGACCACCACTATTCCGTAAGAAATAGTGACTCTGAATGTCCCCTGTCCCAC
GATGGGTACTGCCTCCATGATGGTGTGTGCATGTATATTGAAGCATTGGACAAGTATGCA
TGCAACTGTGTTGTTGGCTACATCGGGGAGCGATGTCAGTACCGAGACCTGAAGTGGTGG
GAACTGCGCCACGCTGGCCACGGGCAGCAGCAGAAGGTCATCGTGGTGGCTGTCTGCGTG
GTGGTGCTTGTCATGCTGCTCCTCCTGAGCCTGTGGGGGGCCCACTACTACAGGACTCAG
AAGCTGCTATCGAAAAACCCAAAGAATCCTTATGAGGAGTCGAGCAGAGATGTGAGGAGT
CGCAGGCCTGCTGACACTGAGGATGGGATGTCCTCTTGCCCTCAACCTTGGTTTGTGGTT
ATAAAAGAACACCAAGACCTCAAGAATGGGGGTCAACCAGTGGCTGGTGAGGATGGCCAG
GCAGCAGATGGGTCAATGCAACCAACTTCATGGAGGCAGGAGCCCCAGTTATGTGGAATG
GGCACAGAGCAAGGCTGCTGGATTCCAGTATCCAGTGATAAGGGCTCCTGTCCCCAGGTA
ATGGAGCGAAGCTTTCATATGCCCTCCTATGGGACACAGACCCTTGAAGGGGGTGTCGAG
AAGCCCCATTCTCTCCTATCAGCTAACCCATTATGGCAACAAAGGGCCCTGGACCCACCA
CACCAAATGGAGCTGACTCAGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
X04571

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_4_Locus:
4q25

# Macromolecular_Interacting_Partner_4_SNPs:
rs2237051; rs4698803; rs11569017; rs11568943; rs9991664; rs11569046; rs35191533; rs11568992; rs11568911; rs28553469; rs11569098; rs11568849; rs2302135; rs11568937; rs11568993; rs11568885; rs11568953; rs4444903; rs11568847; rs11569146; rs3733625; rs35397046; rs11569145; rs11569147; rs2282787; rs1024600; rs2298983; rs2237053; rs881878; rs2881559; rs1024599; rs2067004; rs2190907; rs971695; rs2282784; rs1860129; rs2255355; rs882471; rs2074390; rs971696; rs2298992; rs10029654; rs2237048; rs2298998; rs6533482; rs2298986; rs2298991; rs2074391; rs3796944; rs12506362; rs1005903; rs9995637; rs6815092; rs2237054; rs6533484; rs6823529; rs4698801; rs10010695; rs1860131; rs2250616; rs7677295; rs881841; rs7655579; rs2298978; rs7692976; rs7695064; rs10470911; rs2298993; rs6825106; rs2237043; rs2347139; rs4698755; rs2250724; rs6818260; rs10857004; rs882405; rs2237047; rs6533485; rs7661766; rs6824759; rs6827914; rs11098057; rs11569069; rs2298999; rs6840890; rs4698757; rs7662362; rs2237041; rs6824594; rs929446; rs2074392; rs2282786; rs4141078; rs3822288; rs2237049; rs2237052; rs4698756; rs2074389; rs2237044; rs11098059; rs2298979; rs4698800; rs6837717; rs11098060; rs2237050; rs9307346; rs6811864; rs2298988; rs12510173; rs7661968; rs6832396; rs11568889; rs4698802; rs2190909; rs11568941; rs11098056; rs11568991; rs11568901; rs11098061; rs11568853; rs11569116; rs6810393; rs10017261; rs6854247; rs11569095; rs11098054; rs3796942; rs6836684; rs11569039; rs7685406; rs11569080; rs11568970; rs11568912; rs11098053; rs11569126; rs2298994; rs11568895; rs3216211; rs11569047; rs3733627; rs3796947; rs3822285; rs11569005; rs12640600; rs10488881; rs11569093; rs6811614; rs6836311; rs3796940; rs6811428; rs887027; rs11568946; rs3796945; rs11569134; rs3733626; rs12507356; rs9307347; rs11569057; rs11569045; rs3822287; rs4141077; rs2298987; rs6827611; rs11568866; rs11568994; rs3796943; rs2298989; rs9991904; rs11569082; rs11569121; rs11568927; rs6533483; rs7668520; rs11569115; rs11568942; rs11568898; rs3796941; rs17041111; rs11569109; rs11568850; rs7670908; rs2298977; rs3796948; rs2024114; rs10023272; rs2299001; rs10017564; rs11569021; rs11569020; rs11569092; rs12649348; rs2298982; rs6533481; rs11568959; rs6850557; rs3733628; rs10002971; rs9992755; rs11569087; rs11568975; rs11098062; rs3764861; rs3822286; rs2237045; rs9991367; rs7680062; rs10011112; rs11568961; rs11569104; rs11569105; rs3796946; rs11569033; rs7668015; rs11569090; rs11568987; rs11568926; rs11569089; rs11568874; rs11568915; rs17041036; rs11569068; rs11568969; rs11568984; rs10434002; rs11568877; rs11569100; rs11569101; rs11569061; rs11568930; rs11569077; rs10025078; rs11569078; rs17041171; rs11569103; rs11569003; rs2298997; rs11932661; rs11569124; rs17041151; rs3796949; rs11569042; rs2299000; rs11569138; rs11568957; rs2282785; rs11568954; rs10029765; rs11568860; rs11569075; rs11568904; rs11568894; rs12511518; rs11568855; rs11568974; rs11568865; rs17041117; rs2237042; rs2881560; rs17041140; rs11569008; rs11568944; rs11569055; rs11569062; rs11568929; rs10029105; rs17041119; rs11098058; rs11568903; rs11568976; rs11569070; rs11568951; rs11568958; rs11569006; rs11569023; rs11569026; rs11569013; rs10213531; rs11569118; rs11568871; rs11568905; rs11568910; rs11568897; rs11568924; rs11568938; rs11569067; rs11568979; rs11569034; rs11569049; rs11569019; rs11569099; rs11568996; rs11569085; rs11568878; rs11943900; rs17041066; rs11569084; rs2298990; rs12506702; rs11569038; rs11569114; rs11569009; rs10002835; rs11569094; rs11569043; rs11569132; rs11569130; rs2347137; rs11569140; rs11569016; rs11568966; rs6844856; rs11568931; rs11568985; rs10014383; rs11568955; rs6413482; rs11568972; rs12506078; rs11568997; rs2298996; rs11569007; rs11568902; rs10014805; rs11568856; rs11568982; rs11568893; rs11569108; rs11568880; rs11569014; rs11569074; rs11569081; rs11568875; rs11568962; rs11569041; rs11569088; rs11569102; rs11568933; rs887028; rs11568888; rs11569123; rs10025276; rs11569030; rs11568956; rs11569142; rs11568980; rs11569037; rs11568886; rs11569052; rs12503113; rs2347138; rs11568870; rs17041134; rs12504641; rs11568945; rs11568947; rs11569065; rs11569129; rs11568858; rs2298995; rs11569133; rs11568990; rs17253063; rs11569107; rs11946955; rs3216213; rs11569048; rs11568989; rs11569058; rs11568906; rs11569050; rs2347136; rs11569022; rs11569066; rs11569079; rs2237040; rs11569035; rs11568884; rs11568907; rs11568949; rs11568925; rs17041176; rs11569044; rs11568995; rs11568923; rs11568978; rs11568862; rs11569056; rs11568950; rs7653900; rs11568846; rs11568836; rs3756261; rs11098052; rs11568835; rs11569149; rs12651220; rs11568837; rs11568839; rs11568844; rs11568838; rs11568841; rs11569144; rs6413481; rs11569086; rs28592692; rs35861016; rs11569111; rs41482245; rs41456944; rs41491249; rs35179300; rs41525245; rs11568848; rs11569083; rs34035044; rs2282783; rs10032001; rs34020379; rs35323166; rs11569018; rs11569051; rs34978462; rs11569131; rs10530188; rs4631111; rs28375920; rs11568948; rs11568967; rs11569122; rs34064583; rs13132659; rs11568899; rs11569097; rs11568952; rs11569073; rs34676458; rs35764342; rs28734982; rs41475346; rs11569025; rs2298981; rs11568864; rs41391347; rs41468451; rs13124171; rs11568883; rs11736732; rs11940608; rs34313375; rs11568965; rs35219330; rs28672708; rs11568887; rs11569004; rs3834237; rs9992709; rs35202654; rs11569029; rs11568932; rs11568928; rs10018671; rs11568879; rs35756119; rs11568913; rs11569015; rs11569128; rs3831508; rs10657118; rs35889913; rs36204343; rs41434845; rs34678383; rs11568892; rs11568881; rs11569000; rs11568876; rs41408447; rs12506489; rs28599924; rs35965393; rs11569036; rs36096733; rs11568917; rs11569136; rs35111701; rs11569106; rs13130517; rs28846451; rs13114846; rs28405885; rs35137507; rs11568859; rs35433114; rs35063848; rs35123785; rs11568867; rs13122091; rs11569120; rs11568988; rs11568977; rs11569040; rs33988828; rs34794044; rs11569112; rs7688334; rs28535066; rs11568998; rs11569119; rs11568857; rs33911213; rs28684716; rs11569032; rs11568934; rs11568852; rs41472549; rs35449393; rs34093217; rs11569143; rs11568960; rs36023559; rs41521844; rs33928953; rs34076404; rs36009201; rs11569064; rs34766103; rs34244718; rs2298985; rs28372160; rs11568861; rs11569053; rs11568890; rs13104254; rs11569072; rs34428348; rs13122083; rs35860692; rs35967976; rs35386224; rs35014139; rs41468551; rs34240890; rs34548988; rs2237046; rs11301315; rs34620819; rs41481750; rs11568919; rs41391155; rs35885486; rs35556509; rs11568936; rs11569011; rs10657058; rs35573075; rs11568900; rs41535246; rs33963140; rs11568863; rs11569076; rs11568854; rs28889289; rs28629923; rs11569096; rs41319247; rs35654533; rs10716107; rs11568964; rs11569091; rs28437404; rs11569001; rs2347135; rs28415968; rs11569002; rs11568999; rs34595076; rs2282782; rs28387677; rs28540029; rs41397647; rs11568873; rs11569127; rs11568882; rs3216212; rs882481; rs41353547; rs11301294; rs41421149; rs10649107; rs35122992; rs35428416; rs11569024; rs11568920; rs11569137; rs41471646; rs41335052; rs41412848; rs10027781; rs41335844; rs34890313; rs11569060; rs11568916; rs28825186; rs28642082; rs12374273; rs34223898; rs4279279; rs28471982; rs28729403; rs7699332; rs28662394; rs28888150; rs10015673; rs11568909; rs11569063; rs11568891; rs4273533; rs11433360; rs35339403; rs41335850; rs33925807; rs11569012; rs41322950; rs11568918; rs11569135; rs7666676; rs34888284; rs11568922; rs41494548; rs34482188; rs28803170; rs11569125; rs11568983; rs41505549; rs34071188; rs41508755; rs11569028; rs11568914; rs11568973; rs7668040; rs11568968; rs41475451; rs35408481; rs11569110; rs41464250; rs11568921; rs11568851; rs11568963; rs33995517; rs41496247; rs35810695; rs11569031; rs11569117; rs13129198; rs35517861; rs4510519; rs12502241; rs2881676; rs35170625; rs35632667; rs11568896; rs34339522; rs11569010; rs5860995; rs41478647; rs41356844; rs11569054; rs11433359; rs11568939; rs11402023; rs35084748; rs35383133; rs36052471; rs12502303; rs11569071; rs11568869; rs11568868; rs2298980; rs35394297; rs41350346; rs41501344; rs35310520; rs34611531; rs11568986; rs3775967; rs11568935; rs34109657; rs35410996; rs34785015; rs28719677; rs35249603; rs28414645; rs41336144; rs28564978; rs11287078; rs35647377; rs41528446; rs36139444; rs41402448; rs6413480; rs11568940; rs11568971; rs12648345; rs41433946; rs2298984; rs35889237; rs2299002; rs35892263; rs28687523; rs11568872; rs35368137; rs6823639; rs35699323; rs11569027; rs36055865; rs34977252; rs11569113; rs35531982; rs11387205; rs41498148; rs11569150; rs11568843; rs41492947; rs41454845; rs34481940; rs3756262; rs41475745; rs41403346; rs41455350; rs11569148; rs11568842; rs41475347; rs11568845; rs10708667; rs3756263; rs41344446; rs11568840; rs36074341; rs10021157; rs10021246; rs10021697; rs10021804; rs11098063; rs11569151; rs11569152; rs11569153; rs11569154; rs11569155; rs11569158; rs11569159; rs11569160; rs11569161; rs13149341; rs17040989; rs17040990; rs17041230; rs17238095; rs17316633; rs3756266; rs3756267; rs4698804; rs718768; rs7698924; rs7699288; rs9991044; rs9993323; rs9999824

# Macromolecular_Interacting_Partner_4_General_References:
3491360; 300079; 2789514; 1522591

# Macromolecular_Interacting_Partner_4_References:
10734111; 10935626; 10935637; 11346656

# Macromolecular_Interacting_Partner_5_ID:
8304

# Macromolecular_Interacting_Partner_5_Name:
Thyroglobulin precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
TG

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Thyroglobulin precursor
MALVLEIFTLLASICWVSANIFEYQVDAQPLRPCELQRETAFLKQADYVPQCAEDGSFQT
VQCQNDGRSCWCVGANGSEVLGSRQPGRPVACLSFCQLQKQQILLSGYINSTDTSYLPQC
QDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRCPRSCEIRNRRLLHGVGDKSP
PQCSAEGEFMPVQCKFVNTTDMMIFDLVHSYNRFPDAFVTFSSFQRRFPEVSGYCHCADS
QGRELAETGLELLLDEIYDTIFAGLDLPSTFTETTLYRILQRRFLAVQSVISGRFRCPTK
CEVERFTATSFGHPYVPSCRRNGDYQAVQCQTEGPCWCVDAQGKEMHGTRQQGEPPSCAE
GQSCASERQQALSRLYFGTSGYFSQHDLFSSPEKRWASPRVARFATSCPPTIKELFVDSG
LLRPMVEGQSQQFSVSENLLKEAIRAIFPSRGLARLALQFTTNPKRLQQNLFGGKFLVNV
GQFNLSGALGTRGTFNFSQFFQQLGLASFLNGGRQEDLAKPLSVGLDSNSSTGTPEAAKK
DGTMNKPTVGSFGFEINLQENQNALKFLASLLELPEFLLFLQHAISVPEDVARDLGDVME
TVLSSQTCEQTPERLFVPSCTTEGSYEDVQCFSGECWCVNSWGKELPGSRVRGGQPRCPT
DCEKQRARMQSLMGSQPAGSTLFVPACTSEGHFLPVQCFNSECYCVDAEGQAIPGTRSAI
GKPKKCPTPCQLQSEQAFLRTVQALLSNSSMLPTLSDTYIPQCSTDGQWRQVQCNGPPEQ
VFELYQRWEAQNKGQDLTPAKLLVKIMSYREAASGNFSLFIQSLYEAGQQDVFPVLSQYP
SLQDVPLAALEGKRPQPRENILLEPYLFWQILNGQLSQYPGSYSDFSTPLAHFDLRNCWC
VDEAGQELEGMRSEPSKLPTCPGSCEEAKLRVLQFIRETEEIVSASNSSRFPLGESFLVA
KGIRLRNEDLGLPPLFPPREAFAEQFLRGSDYAIRLAAQSTLSFYQRRRFSPDDSAGASA
LLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSLQIPQCPTTCEKS
RTSGLLSSWKQARSQENPSPKDLFVPACLETGEYARLQASGAGTWCVDPASGEELRPGSS
SSAQCPSLCNVLKSGVLSRRVSPGYVPACRAEDGGFSPVQCDQAQGSCWCVMDSGEEVPG
TRVTGGQPACESPRCPLPFNASEVVGGTILCETISGPTGSAMQQCQLLCRQGSWSVFPPG
PLICSLESGRWESQLPQPRACQRPQLWQTIQTQGHFQLQLPPGKMCSADYADLLQTFQVF
ILDELTARGFCQIQVKTFGTLVSIPVCNNSSVQVGCLTRERLGVNVTWKSRLEDIPVASL
PDLHDIERALVGKDLLGRFTDLIQSGSFQLHLDSKTFPAETIRFLQGDHFGTSPRTWFGC
SEGFYQVLTSEASQDGLGCVKCPEGSYSQDEECIPCPVGFYQEQAGSLACVPCPVGRTTI
SAGAFSQTHCVTDCQRNEAGLQCDQNGQYRASQKDRGSGKAFCVDGEGRRLPWWETEAPL
EDSQCLMMQKFEKVPESKVIFDANAPVAVRSKVPDSEFPVMQCLTDCTEDEACSFFTVST
TEPEISCDFYAWTSDNVACMTSDQKRDALGNSKATSFGSLRCQVKVRSHGQDSPAVYLKK
GQGSTTTLQKRFEPTGFQNMLSGLYNPIVFSASGANLTDAHLFCLLACDRDLCCDGFVLT
QVQGGAIICGLLSSPSVLLCNVKDWMDPSEAWANATCPGVTYDQESHQVILRLGDQEFIK
SLTPLEGTQDTFTNFQQVYLWKDSDMGSRPESMGCRKDTVPRPASPTEAGLTTELFSPVD
LNQVIVNGNQSLSSQKHWLFKHLFSAQQANLWCLSRCVQEHSFCQLAEITESASLYFTCT
LYPEAQVCDDIMESNAQGCRLILPQMPKALFRKKVILEDKVKNFYTRLPFQKLMGISIRN
KVPMSEKSISNGFFECERRCDADPCCTGFGFLNVSQLKGGEVTCLTLNSLGIQMCSEENG
GAWRILDCGSPDIEVHTYPFGWYQKPIAQNNAPSFCPLVVLPSLTEKVSLDSWQSLALSS
VVVDPSIRHFDVAHVSTAATSNFSAVRDLCLSECSQHEACLITTLQTQPGAVRCMFYADT
QSCTHSLQGQNCRLLLREEATHIYRKPGISLLSYEASVPSVPISTHGRLLGRSQAIQVGT
SWKQVDQFLGVPYAAPPLAERRFQAPEPLNWTGSWDASKPRASCWQPGTRTSTSPGVSED
CLYLNVFIPQNVAPNASVLVFFHNTMDREESEGWPAIDGSFLAAVGNLIVVTASYRVGVF
GFLSSGSGEVSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTAR
ATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPMSSSQEVVSCLRQKPAN
VLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQDDGLINRA
KAVKQFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRAL
ENATRDYFIICPIIDMASAWAKRARGNVFMYHAPENYGHGSLELLADVQFALGLPFYPAY
EGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGENYKEF
SELLPNRQGLKKADCSFWSKYISSLKTSADGAKGGQSAESEEEELTAGSGLREDLLSLQE
PGSKTYSK

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
2768

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
304792

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
5.26

# Macromolecular_Interacting_Partner_5_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Lipid transport and metabolism 

# Macromolecular_Interacting_Partner_5_Specific_Function:
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3)

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00135:COesterase;
PF07699:GCC2_GCC3;
PF00086:Thyroglobulin_1

# Macromolecular_Interacting_Partner_5_Signals:
1-19

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
37174

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
THYG_HUMAN (P01266)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
TG

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
TG

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:11764

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>8304 bp
ATGGCCCTGGTCCTGGAGATCTTCACCCTGCTGGCCTCCATCTGCTGGGTGTCGGCCAAT
ATCTTCGAGTACCAGGTTGATGCCCAGCCCCTTCGTCCCTGTGAGCTGCAGAGGGAAACG
GCCTTTCTGAAGCAAGCAGACTACGTGCCCCAGTGTGCAGAGGATGGCAGCTTCCAGACT
GTCCAGTGCCAGAACGACGGCCGCTCCTGCTGGTGTGTGGGTGCCAACGGCAGTGAAGTG
CTGGGCAGCAGGCAGCCAGGACGGCCTGTGGCTTGTCTGTCATTTTGTCAGCTACAGAAA
CAGCAGATCTTACTGAGTGGCTACATTAACAGCACAGACACCTCCTACCTCCCTCAGTGT
CAGGATTCAGGGGACTACGCGCCTGTTCAGTGTGATGTGCAGCATGTCCAGTGCTGGTGT
GTGGACGCAGAGGGGATGGAGGTGTATGGGACCCGCCAGCTGGGGAGGCCAAAGCGATGT
CCAAGGAGCTGTGAAATAAGAAATCGTCGTCTTCTCCACGGGGTGGGAGATAAGTCACCA
CCCCAGTGTTCTGCGGAGGGAGAGTTTATGCCTGTCCAGTGCAAATTTGTCAACACCACA
GACATGATGATTTTTGATCTGGTCCACAGCTACAACAGGTTTCCAGATGCATTTGTGACC
TTCAGTTCCTTCCAGAGGAGGTTCCCTGAGGTATCTGGGTATTGCCACTGTGCTGACAGC
CAAGGGCGGGAACTGGCTGAGACAGGTTTGGAGTTGTTACTGGATGAAATTTATGACACC
ATTTTTGCTGGCCTGGACCTTCCTTCCACCTTCACTGAAACCACCCTGTACCGGATACTG
CAGAGACGGTTCCTCGCAGTTCAATCAGTCATCTCTGGCAGATTCCGATGCCCCACAAAA
TGTGAAGTGGAGCGGTTTACAGCAACCAGCTTTGGTCACCCCTATGTTCCAAGCTGCCGC
CGAAATGGCGACTATCAGGCGGTGCAGTGCCAGACGGAAGGGCCCTGCTGGTGTGTGGAC
GCCCAGGGGAAGGAAATGCATGGAACCCGGCAGCAAGGGGAGCCGCCATCTTGTGCTGAA
GGCCAATCTTGTGCCTCCGAAAGGCAGCAGGCCTTGTCCAGACTCTACTTTGGGACCTCA
GGCTACTTCAGCCAGCACGACCTGTTCTCTTCCCCAGAGAAAAGATGGGCCTCTCCAAGA
GTAGCCAGATTTGCCACATCCTGCCCACCCACGATCAAGGAGCTCTTTGTGGACTCTGGG
CTTCTCCGCCCAATGGTGGAGGGACAGAGCCAACAGTTTTCTGTCTCAGAAAATCTTCTC
AAAGAAGCCATCCGAGCAATTTTTCCCTCCCGAGGGCTGGCTCGTCTTGCCCTTCAGTTT
ACCACCAACCCAAAGAGACTCCAGCAAAACCTTTTTGGAGGGAAATTTTTGGTGAATGTT
GGCCAGTTTAACTTGTCTGGAGCCCTTGGCACAAGAGGCACATTTAACTTCAGTCAATTT
TTCCAGCAACTTGGTCTTGCAAGCTTCTTGAATGGAGGGAGACAAGAAGATTTGGCCAAG
CCACTCTCTGTGGGATTAGATTCAAATTCTTCCACAGGAACCCCTGAAGCTGCTAAGAAG
GATGGTACTATGAATAAGCCAACTGTGGGCAGCTTTGGCTTTGAAATTAACCTACAAGAG
AACCAAAATGCCCTCAAATTCCTTGCTTCTCTCCTGGAGCTTCCAGAATTCCTTCTCTTC
TTGCAACATGCTATCTCTGTGCCAGAAGATGTGGCAAGAGATTTAGGTGATGTGATGGAA
ACGGTACTCGACTCCCAGACCTGTGAGCAGACACCTGAAAGGCTATTTGTCCCATCATGC
ACGACAGAAGGAAGCTATGAGGATGTCCAATGCTTTTCCGGAGAGTGCTGGTGTGTGAAT
TCCTGGGGCAAAGAGCTTCCAGGCTCAAGAGTCAGAGATGGACAGCCAAGGTGCCCCACA
GACTGTGAAAAGCAAAGGGCTCGCATGCAAAGCCTCATGGGCAGCCAGCCTGCTGGCTCC
ACCTTGTTTGTCCCTGCTTGTACTAGTGAGGGACATTTCCTGCCTGTCCAGTGCTTCAAC
TCAGAGTGCTACTGTGTTGATGCTGAGGGTCAGGCCATTCCTGGAACTCGAAGTGCAATA
GGGAAGCCCAAGAAATGCCCCACGCCCTGTCAATTACAGTCTGAGCAAGCTTTCCTCAGG
ACGGTGCAGGCCCTGCTCTCTAACTCCAGCATGCTACCCACCCTTTCCGACACCTACATC
CCACAGTGCAGCACCGATGGGCAGTGGAGACAAGTGCAATGCAATGGGCCTCCTGAGCAG
GTCTTCGAGTTGTACCAACGATGGGAGGCTCAGAACAAGGGCCAGGATCTGACGCCTGCC
AAGCTGCTAGTGAAGATCATGAGCTACAGAGAAGCAGCTTCCGGAAACTTCAGTCTCTTT
ATTCAAAGTCTGTATGAGGCTGGCCAGCAAGATGTCTTCCCGGTGCTGTCACAATACCCT
TCTCTGCAAGATGTCCCACTAGCAGCACTGGAAGGGAAACGGCCCCAGCCCAGGGAGAAT
ATCCTCCTGGAGCCCTACCTCTTCTGGCAGATCTTAAATGGCCAACTCAGCCAATACCCG
GGGTCCTACTCAGACTTCAGCACTCCTTTGGCACATTTTGATCTTCGGAACTGCTGGTGT
GTGGATGAGGCTGGCCAAGAACTGGAAGGAATGCGGTCTGAGCCAAGCAAGCTCCCAACG
TGTCCTGGCTCCTGTGAGGAAGCAAAGCTCCGTGTACTGCAGTTCATTAGGGAAACGGAA
GAGATTGTTTCAGCTTCCAACAGTTCTCGGTTCCCTCTGGGGGAGAGTTTCCTGGTGGCC
AAGGGAATCCGGCTGAGGAATGAGGACCTCGGCCTTCCTCCGCTCTTCCCGCCCCGGGAG
GCTTTCGCGGAGTTTCTGCGTGGGAGTGATTACGCCATTCGCCTGGCGGCTCAGTCTACC
TTAAGCTTCTATCAGAGACGCCGCTTTTCCCCGGACGACTCGGCTGGAGCATCCGCCCTT
CTGCGGTCGGGCCCCTACATGCCACAGTGTGATGCGTTTGGAAGTTGGGAGCCTGTGCAG
TGCCACGCTGGGACTGGGCACTGCTGGTGTGTAGATGAGAAAGGAGGGTTCATCCCTGGC
TCACTGACTGCCCGCTCTCTGCAGATTCCACAGTGCCCGACAACCTGCGAGAAATCTCGA
ACCAGTGGGCTGCTTTCCAGTTGGAAACAGGCTAGATCCCAAGAAAACCCATCTCCAAAA
GACCTGTTCGTCCCAGCCTGCCTAGAAACAGGAGAATATGCCAGGCTGCAGGCATCGGGG
GCTGGCACCTGGTGTGTGGACCCTGCATCAGGAGAAGAGTTGCGGCCTGGCTCGAGCAGC
AGTGCCCAGTGCCCAAGCCTCTGCAATGTGCTCAAGAGTGGAGTCCTCTCTAGGAGAGTC
AGCCCAGGCTATGTCCCAGCCTGCAGGGCAGAGGATGGGGGCTTTTCCCCAGTGCAATGT
GACCAGGCCCAGGGCAGCTGCTGGTGTGTCATGGACAGCGGAGAAGAGGTGCCTGGGACG
CGCGTGACCGGGGGCCAGCCCGCCTGTGAGAGCCCGCGGTGTCCGCTGCCATTCAACGCG
TCGGAGGTGGTTGGTGGAACAATCCTGTGTGAGACAATCTCGGGCCCCACAGGCTCTGCC
ATGCAGCAGTGCCAATTGCTGTGCCGCCAAGGCTCCTGGAGCGTGTTTCCACCAGGGCCA
TTGATATGTAGCCTGGAGAGCGGACGCTGGGAGTCACAGCTGCCTCAGCCCCGGGCCTGC
CAACGGCCCCAGCTGTGGCAGACCATCCAGACCCAAGGGCACTTTCAGCTCCAGCTCCCG
CCGGGCAAGATGTGCAGTGCTGACTACGCGGGTTTGCTGCAGACTTTCCAGGTTTTCATA
TTGGATGAGCTGACAGCCCGCGGCTTCTGCCAGATCCAGGTGAAGACTTTTGGCACCCTG
GTTTCCATTCCTGTCTGCAACAACTCCTCTGTGCAGGTGGGTTGTCTGACCAGGGAGCGT
TTAGGAGTGAATGTTACATGGAAATCACGGCTTGAGGACATCCCAGTGGCTTCTCTTCCT
GACTTACATGACATTGAGAGAGCCTTGGTGGGCAAGGATCTCCTTGGGCGCTTCACAGAT
CTGATCCAGAGTGGCTCATTCCAGCTTCATCTGGACTCCAAGACGTTCCCAGCGGAAACC
ATCCGCTTCCTCCAAGGGGACCACTTTGGCACCTCTCCTAGGACACGGTTTGGGTGCTCG
GAAGGATTCTACCAAGTCTTGACAAGTGAGGCCAGTCAGGACGGACTGGGATGCGTTAAG
TGCCATGAAGGAAGCTATTCCCAAGATGAGGAATGCATTCCTTGTCCTGTTGGATTCTAC
CAAGAACAGGCAGGGAGCTTGGCCTGTGTCCCATGTCCTGTGGGCAGAACGACCATTTCT
GCCGGAGCTTTCAGCCAGACTCACTGTGTCACTGACTGTCAGAGGAACGAAGCAGGCCTG
CAATGTGACCAGAATGGCCAGTATCGAGCCAGCCAGAAGGACAGGGGCAGTGGGAAGGCC
TTCTGTGTGGACGGCGAGGGGCGGAGGCTGCCATGGTGGGAAACAGAGGCCCCTCTTGAG
GACTCACAGTGTTTGATGATGCAGAAGTTTGAGAAGGTTCCAGAATCAAAGGTGATCTTC
GACGCCAATGCTCCTGTGGCTGTCAGATCCAAAGTTCCTGATTCTGAGTTCCCCGTGATG
CAGTGCTTGACAGATTGCACAGAGGACGAGGCCTGCAGCTTCTTCACCGTGTCCACGACG
GAGCCAGAGATTTCCTGTGATTTCTATGCTTGGACAAGTGACAATGTTGCCTGCATGACT
TCTGACCAGAAACGAGATGCACTGGGGAACTCAAAGGCCACCAGCTTTGGAAGTCTTCGC
TGCCAGGTGAAAGTGAGGAGCCATGGTCAAGATTCTCCAGCTGTGTATTTGAAAAAGGGC
CAAGGATCCACCACAACACTTCAGAAACGCTTTGAACCCACTGGTTTCCAAAACATGCTT
TCTGGATTGTACAACCCCATTGTGTTCTCAGCCTCAGGAGCCAATCTAACCGATGCTCAC
CTCTTCTGTCTTCTTGCATGCGACCGTGATCTGTGTTGCGATGGCTTCGTCCTCACACAG
GTTCAAGGAGGTGCCATCATCTGTGGGTTGCTGAGCTCACCCAGTGTCCTGCTTTGTAAT
GTCAAAGACTGGATGGATCCCTCTGAAGCCTGGGCTAATGCTACATGTCCTGGTGTGACA
TATGACCAGGAGAGCCACCAGGTGATATTGCGTCTTGGAGACCAGGAGTTCATCAAGAGT
CTGACACCCTTAGAAGGAACTCAAGACACCTTTACCAATTTTCAGCAGGTTTATCTCTGG
AAAGATTCTGACATGGGGTCTCGGCCTGAGTCTATGGGATGTAGAAAAAACACAGTGCCA
AGGCCAGCATCTCCAACAGAAGCAGGTTTGACAACAGAACTTTTCTCCCCTGTGGACCTC
AACCAGGTCATTGTCAATGGAAATCAATCACTATCCAGCCAGAAGCACTGGCTTTTCAAG
CACCTGTTTTCAGCCCAGCAGGCAAACCTATGGTGCCTTTCTCGTTGTGTGCAGGAGCAC
TCTTTCTGTCAGCTCGCAGAGATAACAGAGAGTGCATCCTTGTACTTCACCTGCACCCTC
TACCCAGAGGCACAGGTGTGTGATGACATCATGGAGTCCAATACCCAGGGCTGCAGACTG
ATCCTGCCTCAGATGCCAAAGGCCCTGTTCCGGAAGAAAGTTATACTGGAAGATAAAGTG
AAGAACTTTTACACTCGCCTGCCGTTCCAAAAACTGATGGGGATATCCATTAGAAATAAA
GTGCCCATGTCTGAAAAATCTATTTCTAATGGGTTCTTTGAATGTGAACGACGGTGCGAT
GCGGACCCATGCTGCACTGGCTTTGGATTTCTAAATGTTTCCCAGTTAAAAGGAGGAGAG
GTGACATGTCTCACTCTGAACAGCTTGGGAATTCAGATGTGCAGTGAGGAGAATGGAGGA
GCCTGGCGCATTTTGGACTGTGGCTCTCCTGACATTGAAGTCCACACCTATCCCTTCGGA
TGGTACCAGAAGCCCATTGCTCAAAATAATGCTCCCAGTTTTTGCCCTTTGGTTGTTCTG
CCTTCCCTCACAGAGAAAGTGTCTCTGGAATCGTGGCAGTCCCTGGCCCTCTCTTCAGTG
GTTGTTGATCCATCCATTAGGCACTTTGATGTTGCCCATGTCAGCACTGCTGCCACCAGC
AATTTCTCTGCTGTCCGAGACCTCTGTTTGTCGGAATGTTCCCAACATGAGGCCTGTCTC
ATCACCACTCTGCAAACCCAACTCGGGGCTGTGAGATGTATGTTCTATGCTGATACTCAA
AGCTGCACACATAGTCTGCAGGGTCGGAACTGCCGACTTCTGCTTCGTGAAGAGGCCACC
CACATCTACCGGAAGCCAGGAATCTCTCTGCTCAGCTATGAGGCATCTGTACCTTCTGTG
CCCATTTCCACCCATGGCCGGCTGCTGGGCAGGTCCCAGGCCATCCAGGTGGGTACCTCA
TGGAAGCAAGTGGACCAGTTCCTTGGAGTTCCATATGCTGCCCCGCCCCTGGCAGAGAGG
CACTTCCAGGCACCAGAGCCCTTGAACTGGACAGGCTCCTGGGATGCCAGCAAGCCAAGG
GCCAGCTGCTGGCAGCCAGGCACCAGAACATCCACGTCTCCTGGAGTCAGTGAAGATTGT
TTGTATCTCAATGTGTTCATCCCTCAGAATGTGGCCCCTAACGCGTCTGTGCTGGTGTTC
TTCCACAACACCATGGACAGGGAGGAGAGTGAAGGATGGCCGGCTATCGACGGCTCCTTC
TTGGCTGCTGTTGGCAACCTCATCGTGGTCACTGCCAGCTACCGAGTGGGTGTCTTCGGC
TTCCTGAGTTCTGGATCCGGAGAGGTGAGTGGCAACTGGGGGCTGCTGGACCAGGTGGCG
GCTCTGACCTGGGTGCAGACCCACATCCGAGGATTTGGCGGGGACCCTCGGCGCGTGTCC
CTGGCAGCAGACCGTGGCGGGGCTGATGTGGCCAGCATCCACCTTCTCACGGCCAGGGCC
ACCAACTCCCAACTTTTCCGGAGAGCTGTGCTGATGGGAGGCTCCGCACTCTCCCCGGCC
GCCGTCATCAGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAGGAGGTCAGT
TGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCCGCCAGAAGCCTGCCAATGTC
CTCAATGATGCCCAGACCAAGCTCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCT
GTGATCGATGGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGGTCTTTATGG
GTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACGGGCTCATCAACAGAGCAAAG
GCTGTGAAGCAATTTGAGGAAAGTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAG
GCACTGCAGAATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCTGCTGCTACA
TGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCTCCTTCTCCCGGGCTCTGGAG
AATGCCACCCGGGACTACTTTATCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCA
AAGAGGGCCCGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGCCATGGCAGC
CTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTCCCTTCTACCCAGCCTACGAG
GGGCAGTTTTCTCTGGAGGAGAAGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCAC
TTCATCAGATCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTACCCACATTT
GCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAGAGAACTACAAGGAGTTCAGT
GAGCTGCTCCCCAATCGACAGGGCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTAC
ATCTCGTCTCTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCAGAGAGTGAA
GAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATCTCCTAAGCCTCCAGGAACCA
GGCTCTAAGACCTACAGCAAGTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
X05615

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:8

# Macromolecular_Interacting_Partner_5_Locus:
8q24

# Macromolecular_Interacting_Partner_5_SNPs:
rs853326; rs2069561; rs1133076; rs10091530; rs180222; rs11535853; rs16893332; rs180223; rs12549018; rs2272707; rs3739274; rs2069548; rs11992497; rs2229843; rs16904774; rs2069550; rs2294024; rs853304; rs2228590; rs16904799; rs2294003; rs17693031; rs2069568; rs16904786; rs2250927; rs2741217; rs940075; rs2741228; rs2739075; rs853303; rs2979022; rs2703006; rs866468; rs2702988; rs180211; rs2140296; rs2739143; rs2403882; rs2687810; rs2739156; rs2739060; rs2703010; rs2204208; rs2246625; rs1523072; rs2248346; rs2739169; rs2741216; rs1357452; rs1474539; rs1000264; rs2244718; rs2739152; rs2687807; rs870685; rs1403481; rs879810; rs2739142; rs2739061; rs2248574; rs2979029; rs2703005; rs873177; rs2702987; rs2142378; rs2739079; rs2246608; rs2979025; rs2687815; rs2739054; rs2979051; rs2687808; rs712054; rs2741209; rs2249869; rs2741223; rs2741205; rs2741210; rs871162; rs2739141; rs2979048; rs2739180; rs885113; rs2741222; rs870539; rs1403480; rs2958670; rs2140295; rs2979020; rs2739071; rs2687834; rs864898; rs2741208; rs2403910; rs2739069; rs2741218; rs2739073; rs2739078; rs2741225; rs853321; rs2687827; rs2702974; rs909359; rs2741211; rs180210; rs2205452; rs2703011; rs876902; rs2958668; rs2741221; rs2142383; rs180208; rs2739148; rs853298; rs872286; rs2739154; rs2245152; rs2979030; rs2703008; rs1523067; rs6988528; rs2005162; rs2958693; rs940074; rs909361; rs2739165; rs2739151; rs2979032; rs4736622; rs6984038; rs6984052; rs6994110; rs2896692; rs6985454; rs11785557; rs1403487; rs4736625; rs4736613; rs2739166; rs13264468; rs2702999; rs1916274; rs4443645; rs2739155; rs2958688; rs885196; rs3847174; rs4336595; rs6990835; rs4736628; rs2037540; rs7818360; rs6471107; rs712055; rs180202; rs4551333; rs10105992; rs4403389; rs4585737; rs2739057; rs7018140; rs4736432; rs3758113; rs868508; rs10106820; rs2739074; rs4478553; rs2702991; rs2103069; rs885195; rs853318; rs2979035; rs2687813; rs853300; rs2958694; rs10113099; rs872643; rs2703013; rs860471; rs4736626; rs7009823; rs2294025; rs7846474; rs2741213; rs180212; rs872285; rs4540390; rs6982788; rs2739161; rs2958677; rs12545138; rs1403485; rs871402; rs1474540; rs10091983; rs1916275; rs6998833; rs7844761; rs10105189; rs4736433; rs869769; rs2958681; rs2739159; rs1033363; rs853296; rs2958674; rs4236897; rs7844649; rs2687843; rs7827903; rs12541260; rs2739058; rs7832522; rs2272706; rs7015412; rs2177296; rs4236895; rs7829428; rs6990302; rs2091036; rs11785901; rs2256476; rs2979034; rs7827937; rs2739149; rs1523070; rs2261147; rs2958686; rs7827533; rs4736624; rs7825913; rs1533909; rs9297863; rs2958671; rs180213; rs11782322; rs2703004; rs11782262; rs1806535; rs2140297; rs4736623; rs10088449; rs2739177; rs2177297; rs2687822; rs6471109; rs2687819; rs2068128; rs6998423; rs853306; rs4736430; rs6981042; rs2703009; rs1403484; rs180217; rs885194; rs180204; rs2739162; rs7814048; rs2703007; rs2739171; rs2403883; rs2248578; rs2958684; rs4612318; rs4736616; rs11776724; rs7845084; rs1879991; rs2958679; rs7823628; rs4301434; rs7000428; rs9297865; rs4278132; rs7844859; rs940073; rs6999702; rs3161; rs1851571; rs2958687; rs951452; rs7844210; rs2687818; rs7817693; rs7824618; rs11782282; rs4736429; rs2958680; rs4601289; rs865488; rs4736431; rs2739163; rs10095925; rs11784620; rs6471111; rs940078; rs1403488; rs2958683; rs7828146; rs2739070; rs2979027; rs2687831; rs9969622; rs10088696; rs1033361; rs1000263; rs853322; rs2739065; rs6994911; rs4074676; rs2244715; rs2293210; rs11785501; rs11786982; rs872644; rs6992986; rs11990839; rs2741212; rs853308; rs2702973; rs17630941; rs1403491; rs1879992; rs2142379; rs1403483; rs926174; rs2702994; rs16904790; rs6981934; rs6993250; rs2958692; rs4548165; rs16904836; rs17702843; rs12679617; rs180219; rs180207; rs862503; rs2687809; rs16904775; rs853297; rs4377944; rs11777992; rs12545159; rs2739064; rs4363178; rs2739053; rs2142384; rs2687832; rs2739170; rs10100520; rs16904796; rs6471112; rs2687828; rs2222452; rs11782027; rs2687824; rs4736629; rs180206; rs3779948; rs3847173; rs16904832; rs10108988; rs869767; rs865909; rs2248331; rs2687830; rs16904802; rs10103821; rs853323; rs11991061; rs3992996; rs2739157; rs6471108; rs16904768; rs10435562; rs17703832; rs1403482; rs11780642; rs12677246; rs10106670; rs13251221; rs853309; rs4388441; rs4236898; rs2142380; rs3779966; rs10097042; rs853319; rs7011493; rs7008436; rs10505603; rs7818576; rs2979021; rs7815657; rs6997874; rs2245562; rs853305; rs2703002; rs16904784; rs13279688; rs2687829; rs1403486; rs10956686; rs864897; rs13254463; rs10102602; rs2979018; rs11998272; rs2739068; rs2245048; rs16904782; rs879811; rs7827593; rs10088671; rs16904789; rs3892189; rs2687826; rs2958669; rs2258483; rs3739281; rs13263649; rs2739158; rs10105991; rs13256652; rs2461801; rs4297024; rs180221; rs16904762; rs2687825; rs4736434; rs2467991; rs853301; rs1851572; rs2702992; rs4361742; rs11777934; rs3779955; rs2741229; rs2702995; rs180205; rs10505604; rs2741214; rs10106542; rs2739145; rs4273838; rs2142382; rs860474; rs2979049; rs16904794; rs2687812; rs2739139; rs10086069; rs7002393; rs3779951; rs2702989; rs12675044; rs6988193; rs4236899; rs7845804; rs7832064; rs17701982; rs17705719; rs909362; rs1033362; rs16904805; rs11996654; rs2178970; rs2245047; rs2739063; rs2687841; rs2687814; rs4529449; rs11997527; rs2741204; rs9283959; rs7843609; rs2702985; rs7014451; rs2739164; rs2256782; rs853311; rs13265497; rs853302; rs10108422; rs2702979; rs2687846; rs11995141; rs4736435; rs10110664; rs853310; rs2246624; rs12545027; rs1523071; rs7842044; rs2739176; rs10108641; rs11989874; rs4236900; rs2178969; rs11777970; rs2741207; rs2294023; rs2741215; rs16904798; rs7812835; rs11779360; rs853307; rs2702997; rs864091; rs2687845; rs16904806; rs2244716; rs2739072; rs4736627; rs12681531; rs2687833; rs2739168; rs7002366; rs2979033; rs2246611; rs16904778; rs3779949; rs853316; rs2896681; rs1573825; rs4736631; rs2178968; rs2248330; rs12544732; rs2245055; rs2979037; rs581399; rs16904824; rs2979026; rs4736630; rs10092459; rs2687820; rs860473; rs6999594; rs16904801; rs9297864; rs180215; rs3857936; rs2702990; rs2687840; rs17693374; rs13263087; rs11990445; rs10096431; rs10956687; rs16904770; rs2687817; rs16904841; rs4142713; rs16904797; rs10105779; rs6984543; rs16904764; rs7844184; rs9649970; rs10093801; rs4606039; rs16904788; rs34349286; rs2979038; rs11774274; rs16904822; rs11778171; rs2739175; rs2958676; rs2294002; rs9774204; rs2979045; rs12549851; rs16904842; rs2739076; rs7013000; rs2979019; rs12677481; rs16904779; rs13253544; rs16904829; rs7001708; rs7013643; rs4641045; rs10095020; rs17623738; rs16904783; rs909357; rs2958700; rs4430073; rs2739140; rs17613233; rs9969645; rs7836183; rs2256252; rs180216; rs17694217; rs11988147; rs10108459; rs1033360; rs2979036; rs16904825; rs16904781; rs2979040; rs2293999; rs17684629; rs2741227; rs7830370; rs12543039; rs4736633; rs16904771; rs17630799; rs967399; rs2142381; rs16904840; rs733735; rs870540; rs180220; rs11784224; rs2246988; rs9297860; rs11784362; rs16904763; rs16904837; rs17703282; rs16904785; rs7824402; rs860475; rs952346; rs3758114; rs16904776; rs2741206; rs9643296; rs2741226; rs10106416; rs2687842; rs2739062; rs11992894; rs12542426; rs2741219; rs16904767; rs16893339; rs6993411; rs10091720; rs2739077; rs16904769; rs10107048; rs16904803; rs2979028; rs2702978; rs10100508; rs2979039; rs11786334; rs7004655; rs11782801; rs16904833; rs1949729; rs16904773; rs2739066; rs6982276; rs16904772; rs17702000; rs6997296; rs13256826; rs6988394; rs10106773; rs16904792; rs872642; rs16904838; rs16904766; rs2739059; rs1403489; rs10103453; rs16904777; rs4142712; rs10099774; rs1554541; rs2958672; rs17693908; rs10956688; rs6994572; rs17705891; rs17624784; rs2702993; rs1523068; rs2702983; rs17693464; rs2958678; rs17633144; rs2979023; rs872645; rs4736621; rs16904780; rs16904761; rs9774265; rs10096095; rs16904828; rs2739144; rs6988035; rs7845018; rs2687823; rs2008303; rs7014463; rs2294000; rs13256171; rs4736614; rs2056525; rs12334347; rs10098314; rs7843654; rs3892606; rs2703003; rs7000137; rs16904793; rs16904839; rs11995077; rs16904765; rs16904800; rs9969601; rs16904827; rs1810396; rs2739067; rs2403911; rs180193; rs180194; rs999101; rs180195; rs12543299; rs2069546; rs2069565; rs2076737; rs2979042; rs2069566; rs12114109; rs2076738; rs2069558; rs35664324; rs35301433; rs2069562; rs16904791; rs2069557; rs11555531; rs13439368; rs2069555; rs2069554; rs3739269; rs10571; rs2958673; rs13264519; rs34791956; rs35549323; rs41383448; rs11356729; rs36076027; rs5895170; rs28376581; rs2103068; rs7830704; rs35937980; rs35412388; rs35317691; rs1851570; rs34552313; rs28506015; rs36055969; rs10604919; rs34562678; rs4607588; rs11779922; rs12544016; rs35270204; rs35137177; rs34773278; rs34136755; rs3779947; rs1523069; rs1474538; rs7843615; rs35394858; rs6993572; rs34099217; rs34868707; rs12680704; rs34642099; rs36014390; rs35803208; rs12676529; rs5895171; rs7834124; rs13276066; rs34047303; rs16904835; rs12674648; rs11340734; rs34810147; rs34771329; rs7011284; rs11777756; rs35105936; rs10099487; rs34588565; rs34748236; rs34455268; rs10095146; rs33925859; rs2739174; rs2741203; rs34313336; rs5895165; rs10618252; rs7000928; rs35589968; rs869768; rs35486009; rs35061080; rs2958697; rs7826586; rs11783470; rs2702976; rs2702982; rs2741224; rs12335293; rs2739160; rs34413321; rs3958178; rs35473851; rs28659831; rs33960269; rs35664939; rs1882978; rs2979050; rs10536232; rs35313509; rs853315; rs16904817; rs10706012; rs7836320; rs2702984; rs10567770; rs33939827; rs10101897; rs35583800; rs33910321; rs35619992; rs10532987; rs5895164; rs11436640; rs2739179; rs6999184; rs2687844; rs12680666; rs34440378; rs35102598; rs34760590; rs35993480; rs5895169; rs35112762; rs10683644; rs2958703; rs2739147; rs10599394; rs860472; rs2687821; rs13267793; rs35551180; rs1963138; rs2703001; rs34075260; rs34057484; rs28758899; rs28441030; rs6986262; rs34171048; rs28406375; rs28433340; rs6993571; rs34667104; rs34691628; rs35639331; rs879816; rs36065345; rs28405864; rs35468299; rs35606126; rs7460288; rs7011285; rs4316133; rs2958685; rs940076; rs35717199; rs33939013; rs11780782; rs36094625; rs10699743; rs34164866; rs10639956; rs28475483; rs11268257; rs10618253; rs34218497; rs35334722; rs16904818; rs2958698; rs35143972; rs5895166; rs34749093; rs34587713; rs35656634; rs34943147; rs33935978; rs7813333; rs35836924; rs11320050; rs10108500; rs13269733; rs10553390; rs12548839; rs2702981; rs2979044; rs10101716; rs2702977; rs2687835; rs34981034; rs33953992; rs11325505; rs35531314; rs16904804; rs7823660; rs34389272; rs11404754; rs35290286; rs853314; rs35375818; rs28372516; rs11992137; rs33951544; rs3837188; rs34003114; rs34683713; rs35802760; rs35601099; rs35663551; rs34907891; rs2979041; rs34323965; rs11394917; rs12680647; rs3946466; rs5895175; rs2958702; rs2739146; rs34657175; rs7844893; rs1882979; rs35758143; rs6995181; rs5895168; rs34384392; rs36011461; rs2293998; rs10539476; rs11780113; rs13249946; rs2739178; rs180201; rs35336483; rs10532986; rs17621034; rs2739150; rs34016052; rs34726287; rs1134547; rs35340418; rs28697159; rs4736617; rs3992995; rs34362315; rs7841083; rs2702986; rs35983466; rs4736427; rs35000085; rs34511753; rs34029436; rs35779760; rs7829320; rs28579253; rs2981294; rs34781226; rs28428818; rs10956685; rs2739055; rs11268816; rs11316187; rs36223872; rs35432641; rs28719581; rs28393420; rs12676508; rs7820791; rs34713535; rs13266643; rs34290542; rs35286448; rs3076090; rs28452373; rs34965607; rs2958695; rs34352106; rs36011474; rs7835552; rs34419422; rs909360; rs34115098; rs3892190; rs34527875; rs34207784; rs2958690; rs12548841; rs853312; rs7012120; rs34649941; rs35056813; rs853324; rs2979047; rs34300693; rs12541293; rs7016620; rs34401566; rs34528002; rs180209; rs35431905; rs10624943; rs10086291; rs2981293; rs2958689; rs853313; rs3832581; rs13439049; rs35340140; rs28402248; rs35292436; rs861203; rs853299; rs11395047; rs11335158; rs10639958; rs33985805; rs11778569; rs35975996; rs34975986; rs35140466; rs10092528; rs13260781; rs35977562; rs34409761; rs35755717; rs34906603; rs35729450; rs35149312; rs35275167; rs35676595; rs16904819; rs2294001; rs35215721; rs1811812; rs4736632; rs10660502; rs34542708; rs940077; rs36225951; rs2958682; rs36002632; rs13254863; rs33990330; rs7840281; rs2979024; rs35079765; rs6992619; rs11997110; rs16904826; rs28445135; rs12547060; rs2702980; rs28727293; rs2979031; rs2467990; rs34843766; rs34669143; rs6989555; rs16904820; rs7461513; rs28654406; rs35917695; rs10094088; rs36221525; rs33910057; rs34799712; rs34475728; rs34861244; rs35457246; rs2294004; rs34338140; rs7011227; rs33972433; rs34300442; rs5895167; rs28654846; rs34989595; rs13263197; rs4576410; rs35944432; rs3992994; rs10095026; rs35636762; rs35059390; rs34637329; rs28620579; rs12680667; rs34249106; rs10650506; rs34971750; rs2739056; rs28680551; rs28573183; rs34904146; rs10112059; rs16904831; rs35584041; rs35769648; rs7015805; rs28547062; rs34581780; rs34569436; rs10570581; rs16904834; rs28640053; rs28384408; rs11269191; rs34691975; rs11277781; rs35468381; rs10102363; rs36110471; rs11988144; rs16904787; rs35844025; rs2958696; rs35542042; rs7828465; rs35161639; rs2739052; rs34491481; rs11359047; rs28758516; rs11786128; rs28540916; rs2979043; rs34420477; rs4404893; rs34052396; rs10639957; rs35870007; rs180214; rs36055972; rs2958701; rs35565593; rs34432553; rs34839909; rs35644874; rs34047530; rs2739167; rs6994282; rs34473243; rs36059290; rs34840168; rs35683386; rs34949600; rs2958675; rs7012887; rs28582446; rs11272738; rs11779877; rs36056438; rs4330673; rs5895163; rs35515477; rs34393101; rs1882977; rs853325; rs34619069; rs5895174; rs180218; rs36223983; rs35376892; rs180203; rs33977608; rs35235993; rs34690484; rs34220859; rs35833882; rs7013696; rs3758109; rs35213262; rs13278046; rs34036189; rs34079651; rs12674632; rs35128090; rs35996460; rs2958691; rs853320; rs34258994; rs33942146; rs35196927; rs2702975; rs454222; rs28611783; rs180199; rs180200; rs180198; rs34146730; rs3834381; rs180197; rs180196; rs3758116; rs436505; rs34276475; rs34933516; rs35054972; rs1006197; rs10087449; rs10093650; rs10093995; rs10096073; rs10099615; rs10106075; rs10107766; rs1010873; rs1049528; rs1049529; rs1049535; rs10755938; rs10808603; rs10808604; rs10956690; rs10956691; rs10956692; rs1122414; rs1123672; rs1124527; rs11990500; rs11993576; rs12164182; rs12549029; rs1403494; rs1533910; rs16904757; rs16904758; rs16904759; rs16904760; rs16904807; rs16904808; rs16904810; rs16904814; rs17622362; rs17683567; rs17695552; rs1916271; rs1916272; rs1916273; rs2037541; rs2069556; rs2069569; rs2142377; rs2205450; rs2205451; rs2244060; rs2249272; rs2252553; rs2252681; rs2252696; rs2252706; rs2252805; rs2252807; rs2252813; rs2252917; rs2253035; rs2256366; rs2293208; rs2403912; rs2461800; rs2467992; rs2467993; rs2472546; rs2472547; rs2472548; rs2687836; rs2687837; rs2702966; rs2702967; rs2702968; rs2702970; rs2702971; rs2702972; rs2702996; rs2703000; rs2703012; rs2739136; rs2739138; rs2739153; rs2739181; rs2739182; rs2741192; rs2741194; rs2741195; rs2741197; rs2741199; rs2741200; rs2741202; rs2777; rs2896691; rs2958699; rs2979046; rs3739266; rs3739268; rs3758110; rs3779965; rs4370513; rs4430072; rs4458855; rs4486183; rs4489309; rs4489310; rs4492356; rs4736436; rs4736618; rs4736619; rs4736620; rs4736634; rs6471110; rs6983548; rs7017140; rs7817183; rs7819747; rs880073; rs880075; rs883685; rs940079; rs954591; rs9942754

# Macromolecular_Interacting_Partner_5_General_References:
3595599; 9186272; 3971976; 3681978; 2991855; 11124863; 10524569; 1639210; 2914619; 8269951; 7793989; 8615697; 8797845; 2760035; 10448091; 12387814; 8094490; 10199792

# Macromolecular_Interacting_Partner_5_References:
15784546; 16313618; 9360296

# Macromolecular_Interacting_Partner_6_ID:
8407

# Macromolecular_Interacting_Partner_6_Name:
Killer cell immunoglobulin-like receptor 2DL3 precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
MHC class I NK cell receptor; Natural killer-associated transcript 2; NKAT-2; NKAT2a; NKAT2b; p58 natural killer cell receptor clone CL-6; p58 NK receptor; p58.2 MHC class-I-specific NK receptor; Killer inhibitory receptor cl 2-3; KIR-023GB; CD158b antigen

# Macromolecular_Interacting_Partner_6_Gene_Name:
KIR2DL3

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Killer cell immunoglobulinlike receptor 2DL3 precursor
MSLMVVSMVCVGFFLLQGAWPHEGVHRKPSLLAHPGPLVKSEETVILQCWSDVRFQHFLL
HREGKFKDTLHLIGEHHDGVSKANFSIGPMMQDLAGTYRCYGSVTHSPYQLSAPSDPLDI
VITGLYEKPSLSAQPGPTVLAGESVTLSCSSRSSYDMYHLSREGEAHERRFSAGPKVNGT
FQADFPLGPATHGGTYRCFGSFRDSPYEWSNSSDPLLVSVTGNPSNSWPSPTEPSSETGN
PRHLHVLIGTSVVIILFILLLFFLLHRWCCNKKNAVVMDQEPAGNRTVNREDSDEQDPQE
VTYAQLNHCVFTQRKITRPSQRPKTPPTDIIVYTELPNAEP

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
341

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
37886

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
6.71

# Macromolecular_Interacting_Partner_6_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00047:ig

# Macromolecular_Interacting_Partner_6_Signals:
1-21

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
246-265

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
780306

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
KI2L3_HUMAN (P43628)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
KIR2DL3

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
KIR2DL3

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:6331

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1026 bp
ATGTCGCTCATGGTCGTCAGCATGGTGTGTGTTGGGTTCTTCTTGCTGCAGGGGGCCTGG
CCACATGAGGGAGTCCACAGAAAACCTTCCCTCCTGGCCCACCCAGGTCCCCTGGTGAAA
TCAGAAGAGACAGTCATCCTGCAATGTTGGTCAGATGTCAGGTTTCAGCACTTCCTTCTG
CACAGAGAAGGGAAGTTTAAGGACACTTTGCACCTCATTGGAGAGCACCATGATGGGGTC
TCCAAGGCCAACTTCTCCATCGGTCCCATGATGCAAGACCTTGCAGGGACCTACAGATGC
TACGGTTCTGTTACTCACTCCCCCTATCAGTTGTCAGCTCCCAGTGACCCTCTGGACATC
GTCATCACAGGTCTATATGAGAAACCTTCTCTCTCAGCCCAGCCGGGCCCCACGGTTCTG
GCAGGAGAGAGCGTGACCTTGTCCTGCAGCTCCCGGAGCTCCTATGACATGTACCATCTA
TCCAGGGAGGGGGAGGCCCATGAACGTAGGTTCTCTGCAGGGCCCAAGGTCAACGGAACA
TTCCAGGCCGACTTTCCTCTGGGCCCTGCCACCCACGGAGGAACCTACAGATGCTTCGGC
TCTTTCCGTGACTCTCCATACGAGTGGTCAAACTCGAGTGACCCACTGCTTGTTTCTGTC
ACAGGAAACCCTTCAAATAGTTGGCCTTCACCCACTGAACCAAGCTCCGAAACCGGTAAC
CCCAGACACCTGCATGTTCTGATTGGGACCTCAGTGGTCATCATCCTCTTCATCCTCCTC
CTCTTCTTTCTCCTTCATCGCTGGTGCTGCAACAAAAAAAATGCTGTTGTAATGGACCAA
GAGCCTGCAGGGAACAGAACAGTGAACAGGGAGGACTCTGATGAACAAGACCCTCAGGAG
GTGACATATGCACAGTTGAATCACTGCGTTTTCACACAGAGAAAAATCACTCGCCCTTCT
CAGAGGCCCAAGACACCCCCAACAGATATCATCGTGTACACGGAACTTCCAAATGCTGAG
CCCTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
L41268

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_6_Locus:
19q13.4

# Macromolecular_Interacting_Partner_6_SNPs:
rs3810343; rs673568; rs1049267; rs10414159; rs10415421; rs3040; rs1049279; rs686822; rs9797815; rs12609523; rs9797798; rs9797807; rs13344950; rs10422891; rs9797797; rs10414839; rs1639426; rs13346500; rs3810344; rs628422; rs4806536; rs11880149; rs13346544; rs13344443; rs8110663; rs11880145; rs11667532; rs688615; rs10414385; rs584993; rs13344702; rs4020195; rs2535716; rs10414870; rs13344481; rs11880144; rs1885389; rs11671969; rs9749374; rs10409751; rs648772; rs1639425; rs2886313; rs4020197; rs35719984; rs4020198; rs35861855; rs2365227; rs4020187; rs2966879; rs2365228; rs34790392; rs595008; rs35343390; rs2365229; rs2365233; rs2886312; rs2365234; rs4020188; rs5828601; rs2916018; rs2916019; rs4080172; rs3952566; rs2916017; rs2966889; rs35100980; rs686298; rs10411723; rs3745918; rs35648125; rs4020196; rs686893; rs35222638; rs623801; rs34843749; rs623416; rs2365230; rs28733586; rs34928845; rs2907926; rs36109446; rs368374; rs626429; rs630832; rs34235630; rs685594; rs2966877; rs10411901; rs8099889; rs8100229; rs35790248; rs2535715; rs11880168; rs28579215; rs8113737; rs2886311; rs36075140; rs28694075; rs2365226; rs4806537; rs624341; rs2966876; rs685530; rs609052; rs670963; rs608126; rs2365232; rs2569660; rs34751810; rs11883037; rs688533; rs12981464; rs687236; rs8099870; rs13346542; rs585059; rs624212; rs2975543; rs4020199; rs623431; rs2886310; rs28376840; rs611614; rs7260102; rs624703; rs34604205; rs28704693; rs35752131; rs10402147; rs2916005; rs28541620; rs35750965; rs4528693; rs683251; rs653716; rs35927204; rs2365225; rs1987855; rs4806439; rs622547; rs2365231; rs2975542; rs10531242; rs8113530; rs10420133; rs630843; rs34980598; rs368378; rs34175449; rs5828599; rs34721307; rs5828600; rs34351816; rs34531776; rs36075941; rs35400788; rs34901169; rs1985422; rs34402747

# Macromolecular_Interacting_Partner_6_General_References:
7716543; 7749980; 8662091; 9430221; 9059894; 9234478; 10196125

# Macromolecular_Interacting_Partner_6_References:
11346656

# Macromolecular_Interacting_Partner_7_ID:
7819

# Macromolecular_Interacting_Partner_7_Name:
Neurogenic locus notch homolog protein 1 precursor

# Macromolecular_Interacting_Partner_7_Synonyms:
Notch 1; hN1; Translocation-associated notch protein TAN-1[Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain]

# Macromolecular_Interacting_Partner_7_Gene_Name:
NOTCH1

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Neurogenic locus notch homolog protein 1 precursor
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDP
NPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLL
TLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN
ECGQKPRLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVT
HECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCPCPPEWTGQYCTEDVDECQ
LMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE
CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGA
NPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCMCMP
GYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG
AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHC
ETNINECSSQPCRLRGTCQDPDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKID
GYECACEPGYTGSMCNSNIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNEC
NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGIVCTCR
EGFSGPNCQTNINECASNPCLNKGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRN
GGECRQSEDYESFSCVCPTAGAKGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGY
SGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGAN
CTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQ
HVVNECDSRPCLLGGTCQDGRGLHRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHT
QYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTG
SYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCL
DLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGF
VGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNG
GTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFT
GPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRD
IPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKY
FSDGHCDSQCNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGHCDQGCNSAECEWDGL
DCAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPY
YGREEELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRRRELDPMDVRGSIVYLE
IDNRQCVQASSQCFQSATDVAAFLGALASLGSLNIPYKIEAVQSETVEPPPPAQLHFMYV
AAAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKN
ASDGALMDDNQNEWGDEDLETKKFRFEEPVVLPDLDDQTDHRQWTQQHLDAADLRMSAMA
PTPPQGEVDADCMDVNVRGPDGFTPLMIASCSGGGLETGNSEEEEDAPAVISDFIYQGAS
LHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQI
LIRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVN
NVDAAVVLLKNGANKDMQNNREETPLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRD
IAQERMHHDIVRLLDEYNLVRSPQLHGAPLGGTPTLSPPLCSPNGYLGSLKPGVQGKKVR
KPSSKGLACGSKEAKDLKARRKKSQDGKGCLLDSSGMLSPVDSLESPHGYLSDVASPPLL
PSPFQQSPSVPLNHLPGMPDTHLGIGHLNVAAKPEMAALGGGGRLAFETGPPRLSHLPVA
SGTSTVLGSSSGGALNFTVGGSTSLNGQCEWLSRLQSGMVPNQYNPLRGSVAPGPLSTQA
PSLQHGMVGPLHSSLAASALSQMMSYQGLPSTRLATQPHLVQTQQVQPQNLQMQQQNLQP
ANIQQQQSLQPPPPPPQPHLGVSSAASGHLGRSFLSGEPSQADVQPLGPSSLAVHTILPQ
ESPALPTSLPSSLVPPVTAAQFLTPPSQHSYSSPVDNTPSHQLQVPEHPFLTPSPESPDQ
WSSSSPHSNVSDWSEGVSSPPTSMQSQIARIPEAFK

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
2556

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
272501

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
4.79

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  development
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  Notch signaling pathway
Process:  cellular process
Process:  cell differentiation
Process:  regulation of biological process
Process:  regulation of development
 ||
>>>
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00023:Ank;
PF00008:EGF;
PF07645:EGF_CA;
PF06816:NOD;
PF07684:NODP;
PF00066:Notch

# Macromolecular_Interacting_Partner_7_Signals:
1-18

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
1737-1757

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
11275980

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
NOTC1_HUMAN (P46531)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
NOTCH1

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
NOTCH1

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:7881

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Cell membrane; single-pass type I membrane protein. NICD:Nucleus (By similarity). Note=Following proteolytical processing NICD is translocated to the nucleus (By similarity)

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>7671 bp
ATGCCGCCGCTCCTGGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGA
GGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGGGAAGTGTGAAGCGGCC
AATGGCACGGAGGCCTGCGTCTGTGGCGGGGCCTTCGTGGGCCCGCGATGCCAGGACCCC
AACCCGTGCCTCAGCACCCCCTGCAAGAACGCCGGGACATGCCACGTGGTGGACCGCAGA
GGCGTGGCAGACTATGCCTGCAGCTGTGCCCTGGGCTTCTCTGGGCCCCTCTGCCTGACA
CCCCTGGACAACGCCTGCCTCACCAACCCCTGCCGCAACGGGGGCACCTGCGACCTGCTC
ACGCTGACGGAGTACAAGTGCCGCTGCCCGCCCGGCTGGTCAGGGAAATCGTGCCAGCAG
GCTGACCCGTGCGCCTCCAACCCCTGCGCCAACGGTGGCCAGTGCCTGCCCTTCGAGGCC
TCCTACATCTGCCACTGCCCACCCAGCTTCCATGGCCCCACCTGCCGGCAGGATGTCAAC
GAGTGTGGCCAGAAGCCCAGGCTTTGCCGCCACGGAGGCACCTGCCACAACGAGGTCGGC
TCCTACCGCTGCGTCTGCCGCGCCACCCACACTGGCCCCAACTGCGAGCGGCCCTACGTG
CCCTGCAGCCCCTCGCCCTGCCAGAACGGGGGCACCTGCCGCCCCACGGGCGACGTCACC
CACGAGTGTGCCTGCCTGCCAGGCTTCACCGGCCAGAACTGTGAGGAAAATATCGACGAT
TGTCCAGGAAACAACTGCAAGAACGGGGGTGCCTGTGTGGACGGCGTGAACACCTACAAC
TGCCCGTGCCCGCCAGAGTGGACAGGTCAGTACTGTACCGAGGATGTGGACGAGTGCCAG
CTGATGCCAAATGCCTGCCAGAACGGCGGGACCTGCCACAACACCCACGGTGGCTACAAC
TGCGTGTGTGTCAACGGCTGGACTGGTGAGGACTGCAGCGAGAACATTGATGACTGTGCC
AGCGCCGCCTGCTTCCACGGCGCCACCTGCCATGACCGTGTGGCCTCCTTTTACTGCGAG
TGTCCCCATGGCCGCACAGGTCTGCTGTGCCACCTCAACGACGCATGCATCAGCAACCCC
TGTAACGAGGGCTCCAACTGCGACACCAACCCTGTCAATGGCAAGGCCATCTGCACCTGC
CCCTCGGGGTACACGGGCCCGGCCTGCAGCCAGGACGTGGATGAGTGCTCGCTGGGTGCC
AACCCCTGCGAGCATGCGGGCAAGTGCATCAACACGCTGGGCTCCTTCGAGTGCCAGTGT
CTGCAGGGCTACACGGGCCCCCGATGCGAGATCGACGTCAACGAGTGCGTCTCGAACCCG
TGCCAGAACGACGCCACCTGCCTGGACCAGATTGGGGAGTTCCAGTGCATGTGCATGCCC
GGCTACGAGGGTGTGCACTGCGAGGTCAACACAGACGAGTGTGCCAGCAGCCCCTGCCTG
CACAATGGCCGCTGCCTGGACAAGATCAATGAGTTCCAGTGCGAGTGCCCCACGGGCTTC
ACTGGGCATCTGTGCCAGTACGATGTGGACGAGTGTGCCAGCACCCCCTGCAAGAATGGT
GCCAAGTGCCTGGACGGACCCAACACTTACACCTGTGTGTGCACGGAAGGGTACACGGGG
ACGCACTGCGAGGTGGACATCGATGAGTGCGACCCCGACCCCTGCCACTACGGCTCCTGC
AAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGC
GAGACCAACATCAACGAGTGCTCCAGCCAGCCCTGCCGCCTACGGGGCACCTGCCAGGAC
CCGGACAACGCCTACCTCTGCTTCTGCCTGAAGGGGACCACAGGACCCAACTGCGAGATC
AACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGAT
GGCTACGAGTGTGCCTGTGAGCCGGGCTACACAGGGAGCATGTGTAACAGCAACATCGAT
GAGTGTGCGGGCAACCCCTGCCACAACGGGGGCACCTGCGAGGACGGCATCAATGGCTTC
ACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGC
AACAGCAACCCCTGCGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGAC
TGTGACCCTGGGTGGAGTGGGACCAACTGTGACATCAACAACAACGAGTGTGAATCCAAC
CCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCATCGTGTGCACCTGCCGG
GAGGGCTTCAGCGGTCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGT
CTGAACAAGGGCACGTGTATTGACGACGTTGCCGGGTACAAGTGCAACTGCCTGCTGCCC
TACACAGGTGCCACGTGTGAGGTGGTGCTGGCCCCGTGTGCCCCCAGCCCCTGCAGAAAC
GGCGGGGAGTGCAGGCAATCCGAGGACTATGAGAGCTTCTCCTGTGTCTGCCCCACGGCT
GGGGCCAAAGGGCAGACCTGTGAGGTCGACATCAACGAGTGCGTTCTGAGCCCGTGCCGG
CACGGCGCATCCTGCCAGAACACCCACGGCGSSTACCGCTGCCACTGCCAGGCCGGCTAC
AGTGGGCGCAACTGCGAGACCGACATCGACGACTGCCGGCCCAACCCGTGTCACAACGGG
GGCTCCTGCACAGACGGCATCAACACGGCCTTCTGCGACTGCCTGCCCGGCTTCCGGGGC
ACTTTCTGTGAGGAGGACATCAACGAGTGTGCCAGTGACCCCTGCCGCAACGGGGCCAAC
TGCACGGACTGCGTGGACAGCTACACGTGCACCTGCCCCGCAGGCTTCAGCGGGATCCAC
TGTGAGAACAACACGCCTGACTGCACAGAGAGCTCCTGCTTCAACGGTGGCACCTGCGTG
GACGGCATCAACTCGTTCACCTGCCTGTGTCCACCCGGCTTCACGGGCAGCTACTGCCAG
CACGTAGTCAATGAGTGCGACTCACGACCCTGCCTGCTAGGCGGCACCTGTCAGGACGGT
CGCGGTCTCCACAGGTGCACCTGCCCCCAGGGCTACACTGGCCCCAACTGCCAGAACCTT
GTGCACTGGTGTGACTCCTCGCCCTGCAAGAACGGCGGCAAATGCTGGCAGACCCACACC
CAGTACCGCTGCGAGTGCCCCAGCGGCTGGACCGGCCTTTACTGCGACGTGCCCAGCGTG
TCCTGTGAGGTGGCTGCGCAGCGACAAGGTGTTGACGTTGCCCGCCTGTGCCAGCATGGA
GGGCTCTGTGTGGACGCGGGCAACACGCACCACTGCCGCTGCCAGGCGGGCTACACAGGC
AGCTACTGTGAGGACCTGGTGGACGAGTGCTCACCCAGCCCCTGCCAGAACGGGGCCACC
TGCACGGACTACCTGGGCGGCTACTCCTGCAAGTGCGTGGCCGGCTACCACGGGGTGAAC
TGCTCTGAGGAGATCGACGAGTGCCTCTCCCACCCCTGCCAGAACGGGGGCACCTGCCTC
GACCTCCCCAACACCTACAAGTGCTCCTGCCCACGGGGCACTCAGGGTGTGCACTGTGAG
ATCAACGTGGACGACTGCAATCCCCCCGTTGACCCCGTGTCCCGGAGCCCCAAGTGCTTT
AACAACGGCACCTGCGTGGACCAGGTGGGCGGCTACAGCTGCACCTGCCCGCCGGGCTTC
GTGGGTGAGCGCTGTGAGGGGGATGTCAACGAGTGCCTGTCCAATCCCTGCGACGCCCGT
GGCACCCAGAACTGCGTGCAGCGCGTCAATGACTTCCACTGCGAGTGCCGTGCTGGTCAC
ACCGGGCGCCGCTGCGAGTCCGTCATCAATGGCTGCAAAGGCAAGCCCTGCAAGAATGGG
GGCACCTGCGCCGTGGCCTCCAACACCGCCCGCGGGTTCATCTGCAAGTGCCCTGCGGGC
TTCGAGGGCGCCACGTGTGAGAATGACGCTCGTACCTGCGGCAGCCTGCGCTGCCTCAAC
GGCGGCACATGCATCTCCGGCCCGCGCAGCCCCACCTGCCTGTGCCTGGGCCCCTTCACG
GGCCCCGAATGCCAGTTCCCGGCCAGCAGCCCCTGCCTGGGCGGCAACCCCTGCTACAAC
CAGGGGACCTGTGAGCCCACATCCGAGAGCCCCTTCTACCGTTGCCTGTGCCCCGCCAAA
TTCAACGGGCTCTTGTGCCACATCCTGGACTACAGCTTCGGGGGTGGGGCCGGGCGCGAC
ATCCCCCCGCCGCTGATCGAGGAGGCGTGCGAGCTGCCCGAGTGCCAGGAGGACGCGGGC
AACAAGGTCTGCAGCCTGCAGTGCAACAACCACGCGTGCGGCTGGGACGGCGGTGACTGC
TCCCTCAACTTCAATGACCCCTGGAAGAACTGCACGCAGTCTCTGCAGTGCTGGAAGTAC
TTCAGTGACGGCCACTGTGACAGCCAGTGCAACTCAGCCGGCTGCCTCTTCGACGGCTTT
GACTGCCAGCGTGCGGAAGGCCAGTGCAACCCCCTGTACGACCAGTACTGCAAGGACCAC
TTCAGCGACGGGCACTGCGACCAGGGCTGCAACAGCGCGGAGTGCGAGTGGGACGGGCTG
GACTGTGCGGAGCATGTACCCGAGAGGCTGGCGGCCGGCACGCTGGTGGTGGTGGTGCTG
ATGCCGCCGGAGCAGCTGCGCAACAGCTCCTTCCACTTCCTGCGGGAGCTCAGCCGCGTG
CTGCACACCAACGTGGTCTTCAAGCGTGACGCACACGGCCAGCAGATGATCTTCCCCTAC
TACGGCCGCGAGGAGGAGCTGCGCAAGCACCCCATCAAGCGTGCCGCCGAGGGCTGGGCC
GCACCTGACGCCCTGCTGGGCCAGGTGAAGGCCTCGCTGCTCCCTGGTGGCAGCGAGGGT
GGGCGGCGGCGGAGGGAGCTGGACCCCATGGACGTCCGCGGCTCCATCGTCTACCTGGAG
ATTGACAACCGGCAGTGTGTGCAGGCCTCCTCGCAGTGCTTCCAGAGTGCCACCGACGTG
GCCGCATTCCTGGGAGCGCTCGCCTCGCTGGGCAGCCTCAACATCCCCTACAAGATCGAG
GCCGTGCAGAGTGAGACCGTGGAGCCGCCCCCGCCGGCGCAGCTGCACTTCATGTACGTG
GCGGCGGCCGCCTTTGTGCTTCTGTTCTTCGTGGGCTGCGGGGTGCTGCTGTCCCGCAAG
CGCCGGCGGCAGCATGGCCAGCTCTGGTTCCCTGAGGGCTTCAAAGTGTCTGAGGCCAGC
AAGAAGAAGCGGCGGGAGCCCCTCGGCGAGGACTCCGTGGGCCTCAAGCCCCTGAAGAAC
GCTTCAGACGGTGCCCTCATGGACGACAACCAGAATGAGTGGGGGGACGAGGACCTGGAG
ACCAAGAAGTTCCGGTTCGAGGAGCCCGTGGTTCTGCCTGACCTGGACGACCAGACAGAC
CACCGGCAGTGGACTCAGCAGCACCTGGATGCCGCTGACCTGCGCATGTCTGCCATGGCC
CCCACACCGCCCCAGGGTGAGGTTGACGCCGACTGCATGGACGTCAATGTCCGCGGGCCT
GATGGCTTCACCCCGCTCATGATCGCCTCCTGCAGCGGGGGCGGCCTGGAGACGGGCAAC
AGCGAGGAAGAGGAGGACGCGCCGGCCGTCATCTCCGACTTCATCTACCAGGGCGCCAGC
CTGCACAACCAGACAGACCGCACGGGCGAGACCGCCTTGCACCTGGCCGCCCGCTACTCA
CGCTCTGATGCCGCCAAGCGCCTGCTGGAGGCCAGCGCAGATGCCAACATCCAGGACAAC
ATGGGCCGCACCCCGCTGCATGCGGCTGTGTCTGCCGACGCACAAGGTGTCTTCCAGATC
CTGATCCGGAACCGAGCCACAGACCTGGATGCCCGCATGCATGATGGCACGACGCCACTG
ATCCTGGCTGCCCGCCTGGCCGTGGAGGGCATGCTGGAGGACCTCATCAACTCACACGCC
GACGTCAACGCCGTAGATGACCTGGGCAAGTCCGCCCTGCACTGGGCCGCCGCCGTGAAC
AATGTGGATGCCGCAGTTGTGCTCCTGAAGAACGGGGCTAACAAAGATATGCAGAACAAC
AGGGAGGAGACACCCCTGTTTCTGGCCGCCCGGGAGGGCAGCTACGAGACCGCCAAGGTG
CTGCTGGACCACTTTGCCAACCGGGACATCACGGATCATATGGACCGCCTGCCGCGCGAC
ATCGCACAGGAGCGCATGCATCACGACATCGTGAGGCTGCTGGACGAGTACAACCTGGTG
CGCAGCCCGCAGCTGCACGGAGCCCCGCTGGGGGGCACGCCCACCCTGTCGCCCCCGCTC
TGCTCGCCCAACGGCTACCTGGGCAGCCTCAAGCCCGGCGTGCAGGGCAAGAAGGTCCGC
AAGCCCAGCAGCAAAGGCCTGGCCTGTGGAAGCAAGGAGGCCAAGGACCTCAAGGCACGG
AGGAAGAAGTCCCAGGATGGCAAGGGCTGCCTGCTGGACAGCTCCGGCATGCTCTCGCCC
GTGGACTCCCTGGAGTCACCCCATGGCTACCTGTCAGACGTGGCCTCGCCGCCACTGCTG
CCCTCCCCGTTCCAGCAGTCTCCGTCCGTGCCCCTCAACCACCTGCCTGGGATGCCCGAC
ACCCACCTGGGCATCGGGCACCTGAACGTGGCGGCCAAGCCCGAGATGGCGGCGCTGGGT
GGGGGCGGCCGGCTGGCCTTTGAGACTGGCCCACCTCGTCTCTCCCACCTGCCTGTGGCC
TCTGGCACCAGCACCGTCCTGGGCTCCAGCAGCGGAGGGGCCCTGAATTTCACTGTGGGC
GGGTCCACCAGTTTGAATGGTCAATGCGAGTGGCTGTCCCGGCTGCAGAGCGGCATGGTG
CCGAACCAATACAACCCTCTGCGGGGGAGTGTGGCACCAGGCCCCCTGAGCACACAGGCC
CCCTCCCTGCAGCATGGCATGGTAGGCCCGCTGCACAGTAGCCTTGCTGCCAGCGCCCTG
TCCCAGATGATGAGCTACCAGGGCCTGCCCAGCACCCGGCTGGCCACCCAGCCTCACCTG
GTGCAGACCCAGCAGGTGCAGCCACAAAACTTACAGATGCAGCAGCAGAACCTGCAGCCA
GCAAACATCCAGCAGCAGCAAAGCCTGCAGCCGCCACCACCACCACCACAGCCGCACCTT
GGCGTGAGCTCAGCAGCCAGCGGCCACCTGGGCCGGAGCTTCCTGAGTGGAGAGCCGAGC
CAGGCAGACGTGCAGCCACTGGGCCCCAGCAGCCTGGCGGTGCACACTATTCTGCCCCAG
GAGAGCCCCGCCCTGCCCACGTCGCTGCCATCCTCGCTGGTCCCACCCGTGACCGCAGCC
CAGTTCCTGACGCCCCCCTCGCAGCACAGCTACTCCTCGCCTGTGGACAACACCCCCAGC
CACCAGCTACAGGTGCCTGAGCACCCCTTCCTGACCCCTTCGCCGGAGTCGCCCGACCAA
TGGTCGTCCTCGTCGCCGCACTCTAATGTGTCTGACTGGTCTGAGGGCGTGTCGTCGCCC
CCGACCTCCATGCAGTCCCAGATCGCGCGCATCCCGGAGGCGTTCAAGTAA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
AF308602

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_7_Locus:
9q34.3

# Macromolecular_Interacting_Partner_7_SNPs:
rs3125001; rs11574885; rs4489420; rs10521; rs2229974; rs34152221; rs3812596; rs2229971; rs2229975; rs2229973; rs2229970; rs11574911; rs6563; rs3124591; rs11574912; rs3124599; rs3125009; rs3124605; rs4880098; rs9411207; rs3124602; rs9411254; rs3125003; rs3829116; rs3124603; rs9411255; rs3124999; rs4880054; rs3125012; rs3124596; rs3812607; rs4489421; rs12001241; rs3125010; rs7030068; rs3125008; rs3812603; rs3124594; rs3124607; rs9411257; rs3013300; rs3013304; rs3124604; rs7036298; rs9411256; rs12552161; rs4077029; rs13290979; rs4880100; rs3812609; rs7852557; rs3812605; rs3125002; rs10781498; rs3124597; rs13301342; rs3124592; rs9411208; rs3124600; rs3125011; rs3125000; rs7048814; rs3124608; rs11145770; rs9411209; rs4880099; rs3124606; rs9411210; rs3812604; rs3125005; rs9411253; rs13290840; rs11574887; rs12001608; rs11574878; rs11574867; rs11574906; rs11574909; rs11574886; rs3013305; rs11574903; rs11574883; rs4265307; rs11145764; rs3125007; rs11574863; rs3124598; rs11574901; rs11145766; rs11574882; rs6560633; rs9632944; rs11574905; rs11574870; rs11574891; rs12002303; rs7021932; rs12686691; rs11145765; rs3124593; rs11574877; rs11145771; rs11574864; rs10117737; rs11574910; rs11145772; rs3124610; rs11574881; rs12344155; rs11574896; rs13300218; rs3812598; rs10870078; rs7867547; rs3125006; rs12555769; rs10870080; rs11574908; rs3013302; rs12001048; rs7029129; rs3013301; rs9411206; rs11574897; rs3124595; rs10870079; rs11574876; rs11574868; rs11574879; rs11145767; rs7850324; rs9314867; rs2990583; rs12555241; rs3013307; rs3013306; rs41309764; rs35652719; rs3812597; rs35136134; rs36049318; rs35083144; rs35962301; rs35900692; rs35980907; rs11574895; rs35627681; rs2229972; rs3812602; rs11574872; rs11574873; rs11574889; rs35320927; rs11574913; rs34162191; rs35791199; rs3124998; rs7036666; rs11574898; rs34370495; rs11574902; rs13285021; rs11574894; rs34963797; rs11574888; rs4880101; rs36119806; rs12343931; rs28546397; rs11361183; rs7864720; rs34368784; rs28421542; rs35608614; rs3124611; rs34893164; rs34238143; rs11574899; rs12341181; rs11145773; rs7870145; rs12346936; rs11574874; rs11574892; rs34517486; rs34383263; rs11574904; rs36059718; rs11403622; rs10125481; rs11574900; rs7470552; rs9695815; rs3124601; rs35987207; rs9695584; rs7040584; rs10711760; rs3013303; rs11574893; rs34253001; rs34464606; rs35863377; rs12682735; rs11789962; rs35939992; rs34061829; rs11574907; rs34878388; rs34253130; rs7021379; rs36106120; rs12342347; rs34488127; rs11574865; rs7021773; rs34724025; rs12348325; rs34045612; rs3812608; rs11145762; rs34500365; rs36018331; rs34868738; rs12343463; rs7874030; rs11574884; rs11574880; rs10685223; rs35116034; rs11278843; rs1889046; rs4302965; rs12555892; rs13294808; rs3124609; rs11574866; rs7856092; rs4880097; rs12352377; rs7028061; rs35911527; rs35768530; rs41309766; rs1058232; rs1058233; rs10870071; rs10870072; rs10870073; rs10870074; rs10870076; rs10870081; rs1110126; rs11145760; rs1139057; rs12004119; rs1571986; rs1571987; rs2095116; rs2282182; rs2282183; rs2282184; rs2990584; rs3013308; rs3013309; rs3013312; rs3013313; rs3013314; rs34376913; rs35135227; rs35971324; rs710411; rs7863766; rs7867068; rs885446; rs9314868

# Macromolecular_Interacting_Partner_7_General_References:
1831692; 10079256; 9590294; 11101851

# Macromolecular_Interacting_Partner_7_References:
12486116

# Macromolecular_Interacting_Partner_8_ID:
8392

# Macromolecular_Interacting_Partner_8_Name:
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase

# Macromolecular_Interacting_Partner_8_Synonyms:
N-acetylglucosaminyltransferase; I-branching enzyme; IGNT

# Macromolecular_Interacting_Partner_8_Gene_Name:
GCNT2

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Nacetyllactosaminide beta1,6Nacetylglucosaminyltransferase
MPLSMRYLFIISVSSVIIFIVFSVFNFGGDPSFQRLNISDPLRLTQVCTSFINGKTRFLW
KNKLMIHEKSSCKEYLTQSHYITAPLSKEEADFPLAYIMVIHHHFDTFARLFRAIYMPQN
IYCVHVDEKATTEFKDAVEQLLSCFPNAFLASKMEPVVYGGISRLQADLNCIRDLSAFEV
SWKYVINTCGQDFPLKTNKEIVQYLKGFKGKNITPGVLPPAHAIGRTKYVHQEHLGKELS
YVIRTTALKPPPPHNLTIYFGSAYVALSREFANFVLHDPRAVDLLQWSKDTFSPDEHFWV
TLNRIPGVPGSMPNASWTGNLRAIKWSDMEDRHGGCHGHYVHGICIYGNGDLKWLVNSPS
LFANKFELNTYPLTVECLELRHRERTLNQSETAIQPSWYF

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
400

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
45855

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
8.32

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  UDP-glycosyltransferase activity
Function:  acetylglucosaminyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells

# Macromolecular_Interacting_Partner_8_Pathway:
map00602  Blood group glycolipid biosynthesis-neolactoseries

# Macromolecular_Interacting_Partner_8_Reaction:
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF02485:Branch

# Macromolecular_Interacting_Partner_8_Signals:
1-23

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
EC 2.4.1.150

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
307298

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
GCNT2_HUMAN (Q06430)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
GCNT2

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
GCNT2

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:4204

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1203 bp
ATGCCTTTATCAATGCGTTACCTCTTCATAATTTCTGTCTCTAGTGTAATTATTTTTATC
GTCTTCTCTGTGTTCAATTTTGGGGGAGATCCAAGCTTCCAAAGGCTAAATATCTCAGAC
CCTTTGAGGCTGACTCAAGTTTGCACATCTTTTATCAATGGAAAAACACGTTTCCTGTGG
AAAAACAAACTAATGATCCATGAGAAGTCTTCTTGCAAGGAATACTTGACCCAGAGCCAC
TACATCACAGCCCCTTTATCTAAGGAAGAAGCTGACTTTCCCTTGGCATATATAATGGTC
ATCCATCATCACTTTGACACCTTTGCAAGGCTCTTCAGGGCTATTTACATGCCCCAAAAT
ATCTACTGTGTTCATGTGGATGAAAAAGCAACAACTGAATTTAAAGATGCGGTAGAGCAA
CTATTAAGCTGCTTCCCAAACGCTTTTCTGGCTTCCAAGATGGAACCCGTTGTCTATGGA
GGGATCTCCAGGCTCCAGGCTGACCTGAACTGCATCAGAGATCTTTCTGCCTTCGAGGTC
TCATGGAAGTACGTTATCAACACCTGTGGGCAAGACTTCCCCCTGAAAACCAACAAGGAA
ATAGTTCAGTATCTGAAAGGATTTAAAGGTAAAAATATCACCCCAGGGGTGCTGCCCCCA
GCTCATGCAATTGGACGGACTAAATATGTCCACCAAGAGCACCTGGGCAAAGAGCTTTCC
TATGTGATAAGAACAACAGCGTTGAAACCGCCTCCCCCCCATAATCTCACAATTTACTTT
GGCTCTGCCTATGTGGCTCTATCAAGAGAGTTTGCCAACTTTGTTCTGCATGACCCACGG
GCTGTTGATTTGCTCCAGTGGTCCAAGGACACTTTCAGTCCTGATGAGCATTTCTGGGTG
ACACTCAATAGGATTCCAGGTGTTCCTGGCTCTATGCCAAATGCATCCTGGACTGGAAAC
CTCAGAGCTATAAAGTGGAGTGACATGGAAGACAGACACGGAGGCTGCCACGGCCACTAT
GTACATGGTATTTGTATCTATGGAAACGGAGACTTAAAGTGGCTGGTTAATTCACCAAGC
CTGTTTGCTAACAAGTTTGAGCTTAATACCTACCCCCTTACTGTGGAATGCCTAGAACTG
AGGCATCGCGAAAGAACCCTCAATCAGAGTGAAACTGCGATACAACCCAGCTGGTATTTT
TGA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
L19659

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_8_Locus:
6p24

# Macromolecular_Interacting_Partner_8_SNPs:
Not Available

# Macromolecular_Interacting_Partner_8_General_References:
8449405; 7579796; 9405606

# Macromolecular_Interacting_Partner_8_References:
12417415; 12678489

End of HMDB00174

Beginning of HMDB00175
# Accession_No:
HMDB00175

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-13 11:22:36

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Inosinic acid

# Description:
A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.
Inosinic acid is a nucleotide present in muscle and other tissues. It is formed by the deamination of AMP and when hydrolysed produces inosine.
Inosinic acid is the ribonucleotide of hypoxanthine and is the first compound formed during the synthesis of purine. (Wikipedia)

# Synonyms:
5'-IMP; 5'-Inosinate; 5'-Inosine monophosphate; 5'-Inosinic acid; IMP; Inosine 5'-monophosphate; Inosine 5'-phosphate; Inosine Monophosphate; Inosine-5'-monophosphate

# Chemical_IUPAC_Name:
[3,4-dihydroxy-5-(6-hydroxypurin-9-yl)-oxolan-2-yl]methoxyphosphonic acid

# Chemical_Formula:
C10H13N4O8P

# Chemical_Structure:
tbl_chemical:::HMDB00175_ZOOM.png:::119283234614717072

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00175_THUMB.png:::119283234404541345

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines; Nucleosides

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; secondary alcohol; 1,2-diol; oxo(het)arene; phosphoric acid ester; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of Alanine and aspartate metabolism; Component of Purine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
348.04712

# Molecular_Weight_Avg:
348.20596

# Smiles_String_isomeric:
O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)N2C=NC3=C2N=CNC3=O

# Smiles_String_canonical:
OC1C(COP(O)(O)=O)OC(C1O)N2C=NC3=C2N=CNC3=O

# KEGG_Compound_ID:
C00130

# BioCyc_ID:
IMP

# PubChem_CID:
8582

# PubChem_SID:
6436024; 177307; 824841; 151738; 834953; 820670; 820531; 819101; 824410; 834259; 3430; 835761; 826549; 829137; 835836; 820101; 820681; 8028199; 823030; 826551; 8025323; 835066; 820736; 3725895; 824419; 835854; 829142; 820739; 835070; 8145617; 831000; 8028013; 824422; 825944; 7888381; 835063

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
33960

# Wikipedia_ID:
Inosinic acid

# METLIN_ID:
5196

# Ref_ID:
9534937; 11575617; 9476857; 7614924; 8680053; 8583409; 10484580; 16331129; 15882454; 16286893; 2352192; 12871718; 7665417; 11053315; 8894971; 12451183

# ChEBI_ID:
17202

# CAS_Registry_Number:
131-99-7

# InChI:
InChI=1/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

# Synthesis_Reference:
 Journal of Organic Chemistry  (1965),  30(9),  3211-12.

# Melting_Point:
Not Available

# Melting_Point_predicted:
163.3 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
5.92 mg/mL [MEYLAN,WM et al. (1996)]; 3.05 mg/mL [Predicted by ALOGPS]

# phys_charge:
-2

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.04 [Predicted by ALOGPS]; -3 [Predicted by PubChem via XLOGP]; -1.50 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00175_MSDS_1.html:::153465898191670

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00130.mol:::113272381214011503

# SDF_File_[Text]:
tbl_chemical:::HMDB00175.sdf:::119283233961237127

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00175.pdb:::119283234265555148

# PDB_ID:
1B4D

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041201_P08_12_BA_1DP_presat.png:::114625845536562898

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041201_P08_12_BA_1DP_presat.zip:::114625845543129714

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041201_P08_12_BA_1DP_Assigned.png:::114625845544778595

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041201_P08_12_BA_1DP_presat.png:::115263185695560126

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041201_P08_12_BA_1DP_presat.zip:::115263185744161488

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041201_P08_12_BA_2DHSQC_994.png:::11480776415403330

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041201_P08_12_BA_2DHSQC_994.zip:::114807764156539924

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041201_P08_12_BA_2DHSQC_994_Assigned.png:::116284039382473752

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Inosinic acid.gif:::1132732118500999549

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00175_peaks.txt:::1156309596923320775

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Inosinic acid_C.gif:::1132737712036492906

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00175_peaks.txt:::1156310786382828068

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00175.png:::1165953913709440347; Medium Energy:tbl_ms:::HMDB00175.png:::1165953668445442315; High Energy:tbl_ms:::HMDB00175.png:::1165953752612812972

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000175.png:::116907444379610102

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000175.txt:::116907444379684259

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000175.png:::116890830115634777

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000175.txt:::116890830145396013

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
CSF; Cellular Cytoplasm

# Concentration_[Normal]:
Cerebrospinal_Fluid(CSF)	3.19 (0.00 +/- 19.70)	umol/L	Adult:>18_yrs_old	Both	Normal	11102727
Cellular_Cytoplasm	10	umol/L	Adult:>18_yrs_old	Both	Normal	15882454


# Concentration_[Abnormal]:
Cerebrospinal_Fluid(CSF)	2.31(0.00-41.40)	umol/L	Adult:>18_yrs_old	Both	Simple ffebrile seizures	11102727 
Cerebrospinal_Fluid(CSF)	2.48 (0.00 +/- 27.20)	umol/L	Adult:>18_yrs_old	Both	Complex febrile seizures	11102727 


# Associated_Disorders:
Complex febrile seizures; Simple ffebrile seizures

# Pathway_Names:
Starch and sucrose metabolism;Purine metabolism;Nicotinate and nicotinamide metabolism;Alanine and aspartate metabolism

# Pathway_Images:
;Purine_Synthesis.jpg;Nicotinamide_synthesis_(NADH).jpg;Aspartate_and_Alanine_metabolism.jpg

# KEGG_Images:
map00500;map00230;map00760;map00252

# Pathway_Graphs:
;Purine_Synthesis_Graph.jpg;Nicotinamide_synthesis_(NADH)_Graph.jpg;Aspartate_and_Alanine_metabolism_Graph.jpg

# Pathway_SBMLs:
;Purine_Synthesis.xml;Nicotinamide_synthesis_(NADH).xml;Aspartate_and_Alanine_metabolism.xml

# Metabolic_Enzyme_1_ID:
5612

# Metabolic_Enzyme_1_Name:
Glycogen phosphorylase, brain form

# Metabolic_Enzyme_1_Synonyms:
Not Available

# Metabolic_Enzyme_1_Gene_Name:
PYGB

# Metabolic_Enzyme_1_Protein_Sequence:
>Glycogen phosphorylase, brain form
MAKPLTDSEKRKQISVRGLAGLGDVAEVRKSFNRHLHFTLVKDRNVATPRDYFFALAHTV
RDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTMVNLGLQNACDEAIYQLGLDL
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKIVNGWQVEEA
DDWLRYGNPWEKARPEYMLPVHFYGRVEHTPDGVKWLDTQVVLAMPYDTPVPGYKNNTVN
TMRLWSAKAPNDFKLQDFNVGDYIEAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTCFETFPDKVAIQLNDTHPALSIPELMRILVDVEKV
DWDKAWEITKKTCAYTNHTVLPEALERWPVSMFEKLLPRHLEIIYAINQRHLDHVAALFP
GDVDRLRRMSVIEEGDCKRINMAHLCVIGSHAVNGVARIHSEIVKQSVFKDFYELEPEKF
QNKTNGITPRRWLLLCNPGLADTIVEKIGEEFLTDLSQLKKLLPLVSDEVFIRDVAKVKQ
ENKLKFSAFLEKEYKVKINPSSMFDVHVKRIHEYKRQLLNCLHVVTLYNRIKRDPAKAFV
PRTVMIGGKAAPGYHMAKLIIKLVTSIGDVVNHDPVVGDRLKVIFLENYRVSLAEKVIPA
ADLSQQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGAENLFIFGLRVEDVE
ALDRKGYNAREYYDHLPELKQAVDQISSGFFSPKEPDCFKDIVNMLMHHDRFKVFADYEA
YMQCQAQVDQLYRNPKEWTKKVIRNIACSGKFSSDRTITEYAREIWGVEPSDLQIPPPNI
PRD

# Metabolic_Enzyme_1_Number_of_Residues:
843

# Metabolic_Enzyme_1_Molecular_Weight:
96697

# Metabolic_Enzyme_1_Theoretical_pI:
6.85

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
Function:  phosphorylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

# Metabolic_Enzyme_1_Pathway:
map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_1_Reaction:
(1,4-alpha-D-glucosyl)n + phosphate = (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00343:Phosphorylase

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.1.1

# Metabolic_Enzyme_1_GenBank_ID_Protein:
307200

# Metabolic_Enzyme_1_SwissProt_ID:
PYGB_HUMAN (P11216)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
PYGB

# Metabolic_Enzyme_1_Geneatlas_id:
PYGB

# Metabolic_Enzyme_1_hgnc_id:
HGNC:9723

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>2592 bp
ATGGGCGAACCGCTGACGGACAGCGAGAAGCGGAAGCAGATCAGCGTGCGCGGCCTGGCG
GGGCTAGGCGACGTGGCCGAGGTGCGGAAGAGCTTCAACCGGCACTTGCACTTCACGCTG
GTCAAGGACCGCAATGTGGCCACGCCCCGCGACTACTTCTTCGCGCTGGCGCACACGGTG
CGCGACCACCTCGTGGGCCGCTGGATCCGCACGCAGCAGCACTACTACGAGCGCGACCCC
AAGCGAATTTATTATCTTTCCCTGGAATTCTACATGGGTCGCACGCTGCAGAACACGATG
GTGAACCTGGGCCTTCAGAATGCCTGCGATGAAGCCATCTATCAGTTGGGGTTAGACTTG
GAGGAACTCGAGGAGATAGAAGAAGATGCTGGCCTTGGGAATGGAGGCCTGGGGAGGCTG
GCAGCGTGTTTCCTTGACTCAATGGCTACCTTGGGCCTGGCAGCATACGGCTATGGAATC
CGCTATGAATTTGGGATTTTTAACCAGAAGATTGTCAATGGCTGGCAGGTAGAGGAGGCC
GATGACTGGCTGCGCTACGGCAACCCCTGGGAGAAAGCGCGGCCTGAGTATATGCTTCCC
GTGCACTTCTACGGACGCGTGGAGCACACCCCCGACGGCGTGAAGTGGCTGGACACACAG
GTGGTGCTGGCCATGCCCTACGACACCCCAGTGCCCGGCTACAAGAACAACACCGTCAAC
ACCATGCGGCTGTGGTCCGCAAGGGCTCCCAACGACTTCAAGCTGCAGGACTTCAACGTG
GGAGACTACATCGAGGCGGTCCTGGACCGGAACTTGGCTGAGAACATCTCCAGGGTCCTG
TATCCAAATGATAACTTCTTTGAGGGGAAGGAGCTGCGGCTGAAGCAGGAGTACTTCGTG
GTGGGCGCCACGCTCCAGGACATCATCCGCCGCTTCAAGTCGTCCAAGTTCGGCTGCCGG
GACCCTGTGAGAACCTGTTTCGAGACGTTCCCAGACAAGGTGGCCATCCAGCTGAACGAC
ACCCACCCCGCCCTCTCCATCCCTGAGCTCATGCGGATCCTGGTGGACGTGGAGAAGGTG
GACTGGGACAAGGCCTGGGAAATCACGAAGAAGACCTGTGCATACACCAACCACACTGTG
CTGCCTGAGGCCTTGGAGCGCTGGCCCGTGTCCATGTTTGAGAAGCTGCTGCCGCGGCAC
CTGGAGATAATCTATGCCATCAACCAGCGGCACCTGGACCACGTGGCCGCGCTGTTTCCC
GGCGATGTGGACCGCCTGCGCAGGATGTCTGTGATCGAGGAGGGGGACTGCAAGCGGATC
AACATGGCCCACCTGTGTGTGATTGGGTCCCATGCTGTCAATGGTGTGGCGAGGATCCAC
TCGGAGATCGTGAAACAGTCGGTCTTTAAGGATTTTTATGAACTGGAGCCAGAGAAGTTC
CAGAATAAGACCAATGGCATCACCCCCCGCCGGTGGCTGCTGCTGTGCAACCCGGGGCTG
GCCGATACCATCGTGGAGAAAATTGGGGAGGAGTTCCTGACTGACCTGAGCCAGCTGAAG
AAGCTGCTGCCGCTGGTCAGTGACGAGGTGTTCATCAGGGACGTGGCCAAGGTCAAACAG
GAGAACAAGCTCAAGTTCTCGGCCTTCCTGGAGAAGGAGTACAAGGTGAAGATCAACCCC
TCCTCCATGTTCGATGTGCATGTGAAGAGGATCCACGAGTACAAGCGGCAGCTGCTCAAC
TGCCTGCACGTCGTCACCCTGTACAATCGAATCAAGAGAGACCCGGCCAAGGCTTTTGTG
CCCAGGACTGTTATGATTGGGGGCAAGGCAGCGCCCGGTTACCACATGGCCAAGCTGATC
ATCAAGTTGGTCACCTCCATCGGCGACGTCGTCAATCATGACCCAGTTGTGGGTGACAGG
TTGAAAGTGATCTTCCTGGAGAACTACCGTGTGTCCTTGGCTGAGAAAGTGATCCCGGCC
GCTGATCTGTCGCAGCAGATCTCCACTGCAGGCACCGAGGCCTCAGGCACAGGCAACATG
AAGTTCATGCTCAACGGGGCCCTCACCATCGGCACCATGGACGGCGCCAACGTGGAGATG
GCCGAGGAGGCCGGGGCCGAGAACCTCTTCATCTTCGGCCTGCGGGTGGAGGATGTCGAG
GCCTTGGACCGGAAAGGGTACAATGCCAGGGAGTACTACGACCACCTGCCCGAGCTGAAG
CAGGCCGTGGACCAGATCAGCAGTGGCTTTTTTTCTCCCAAGGAGCCAGACTGCTTCAAG
GACATCGTGAACATGCTGATGCACCATGACAGGTTCAAGGTGTTTGCAGACTATGAAGCC
TACATGCAGTGCCAGGCACAGGTGGACCAGCTGTACCGGAACCCCAAGGAGTGGACCAAG
AAGGTCATCAGGAACATCGCCTGCTCGGGCAAGTTCTCCAGTGACCGGACCATCACGGAG
TATGCACGGGAGATCTGGGGTGTGGAGCCCTCCGACCTGCAGCTTCAGCACCTGCCCCAC
CCAGAGTGGGAGTCAGGTGGAGCCACCTGCTGGGCTCCCCCAGAACTTTGCACACATCTT
GCTATGTATTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
J03544

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_1_Locus:
20p11.2-p11.1

# Metabolic_Enzyme_1_SNPs:
rs2227891; rs2228976; rs2227892; rs2227890; rs2228977; rs16987612; rs6515626; rs6050486; rs2261720; rs2257808; rs2261109; rs910996; rs2424698; rs6050510; rs2261785; rs2424699; rs2257233; rs2261794; rs2257705; rs2261115; rs2261698; rs2257809; rs2281562; rs2257464; rs2261784; rs2260997; rs2474772; rs2257461; rs2424700; rs2261795; rs7269045; rs6050512; rs2261790; rs2261753; rs2261747; rs2257712; rs2474769; rs2257370; rs6050511; rs6037075; rs1555329; rs2258052; rs6115107; rs2281558; rs3787078; rs2258053; rs2145125; rs2258201; rs6107024; rs11697384; rs6115109; rs2257991; rs8118763; rs753009; rs910997; rs1555331; rs6107023; rs6115118; rs2258563; rs6050509; rs6050502; rs6037070; rs4813555; rs7273544; rs6115115; rs2257432; rs6115101; rs2281559; rs8184820; rs2474767; rs3787082; rs2424704; rs8116542; rs6050487; rs2424701; rs3787081; rs6138555; rs3787080; rs1555330; rs8124539; rs8114792; rs2500411; rs2258135; rs2474777; rs6115117; rs2257982; rs8120601; rs6115114; rs6107017; rs2474763; rs12624460; rs2257988; rs11087508; rs2474770; rs6037071; rs13038092; rs2500410; rs6050513; rs11087511; rs6132824; rs2474773; rs2424703; rs6050501; rs2387734; rs11699953; rs6076328; rs6050488; rs12624693; rs2145126; rs12625357; rs12625045; rs2474766; rs11697736; rs6107021; rs6132825; rs6115121; rs2500413; rs7274919; rs6037069; rs6115106; rs3002702; rs2474762; rs2257649; rs8115188; rs2180597; rs6115116; rs6050515; rs4815398; rs2257985; rs12624472; rs8125980; rs6107022; rs6107019; rs2258066; rs2258617; rs2273473; rs6138553; rs7274104; rs6132822; rs11549036; rs6037077; rs6115125; rs6115124; rs35481467; rs6050484; rs35073849; rs2228978; rs6115120; rs35669741; rs35189278; rs6083789; rs2474764; rs11474310; rs34233544; rs4619688; rs34170256; rs11483996; rs34871259; rs12625447; rs7272247; rs11472555; rs6083794; rs6115113; rs6115108; rs8125437; rs6050485; rs11472504; rs11471241; rs35760653; rs2254046; rs3838000; rs6050503; rs7274130; rs11473890; rs6050520; rs6083790; rs6050507; rs2180596; rs6115102; rs10582106; rs6115129; rs6037079; rs7353137; rs11466827; rs6050493; rs2474774; rs6050491; rs6107018; rs35358504; rs11468635; rs11468776; rs13043218; rs34067778; rs34827380; rs11475816; rs41282330; rs6138556; rs5841050; rs34496209; rs6050498; rs13043643; rs34360139; rs35375864; rs13044624; rs6107020; rs6138551; rs11699652; rs2474776; rs6115123; rs2474768; rs6050508; rs11312793; rs35716293; rs6115104; rs35058859; rs36105797; rs6050494; rs13433150; rs11470476; rs34346429; rs6050492; rs11471520; rs6115128; rs6115103; rs12106151; rs2983489; rs6050504; rs11468520; rs6083788; rs41282328; rs6050490; rs11087510; rs28770021; rs35286896; rs4364079; rs6050521; rs11475085; rs6138558; rs6037068; rs7352961; rs11480235; rs33973694; rs7269584; rs6115130; rs2983490; rs11350552; rs6115110; rs5841051; rs35988788; rs35243193; rs2281561; rs6050495; rs6138552; rs6076330; rs35609563; rs12626048; rs7363911; rs6083793; rs6115122; rs34299454; rs6115105; rs34646441; rs2474775; rs35264724; rs33964550; rs6050505; rs12625048; rs2474771; rs11477346; rs2500426; rs6050522; rs6050519; rs34336965; rs6138559; rs8114789; rs36117882; rs11470854; rs35760227; rs3841696; rs5841052; rs13433144; rs2281560; rs6050523; rs1118963; rs33999482; rs35370770; rs34672197; rs13038488; rs35258354; rs34316192; rs34427422; rs35256912; rs11479739; rs6037073; rs13043662; rs3787079; rs34204571; rs6083791; rs6115111; rs11908154; rs34776023; rs7272959; rs1077889; rs28881233; rs6083792; rs11480711; rs6138554; rs13037005; rs2474765; rs35263526; rs6050483; rs34955390; rs1046073; rs10966; rs1130694; rs11905042; rs2258719; rs2258769; rs2259873; rs2260197; rs2261796; rs2474779; rs2474780; rs6050471; rs6050473; rs6050475; rs6050476; rs6050477; rs6050481; rs6107016; rs6107027; rs6115098; rs6115100; rs7019; rs7344105; rs746748; rs8119343; rs9927

# Metabolic_Enzyme_1_General_References:
3346228; 2615594; 11780052; 12665801

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5233

# Metabolic_Enzyme_2_Name:
Cytosolic 5'-nucleotidase 1A

# Metabolic_Enzyme_2_Synonyms:
Cytosolic 5'-nucleotidase IA; cN1A; cN-IA; cN-I

# Metabolic_Enzyme_2_Gene_Name:
NT5C1A

# Metabolic_Enzyme_2_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
AMEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSR
ALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSED
VFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKV
REAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKA
HENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSW
GLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTA
PAKQAPSAQ

# Metabolic_Enzyme_2_Number_of_Residues:
368

# Metabolic_Enzyme_2_Molecular_Weight:
41021

# Metabolic_Enzyme_2_Theoretical_pI:
6.52

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia

# Metabolic_Enzyme_2_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_2_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
12659324

# Metabolic_Enzyme_2_SwissProt_ID:
5NT1A_HUMAN (Q9BXI3)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
NT5C1A

# Metabolic_Enzyme_2_Geneatlas_id:
NT5C1A

# Metabolic_Enzyme_2_hgnc_id:
HGNC:17819

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1107 bp
ATGGAACCTGGGCAGCCCCGGGAGCCCCAGGAGCCCCGCGAGCCCGGGCCAGGAGCGGAG
ACCGCTGCGGCCCCGGTCTGGGAGGAAGCCAAGATTTTCTACGACAACCTCGCGCCCAAG
AAGAAACCCAAATCGCCCAAGCCTCAGAATGCAGTCACCATCGCTGTGTCCTCCCGAGCC
TTGTTTCGCATGGACGAGGAGCAGCAGATCTACACGGAGCAGGGCGTGGAGGAGTACGTG
CGCTACCAGCTGGAACATGAGAACGAACCCTTCAGTCCCGGGCCAGCCTTCCCTTTTGTG
AAGGCTCTGGAGGCCGTGAACAGGCGGCTGCGGGAGCTGTACCCTGATAGTGAGGACGTC
TTCGACATCGTCCTCATGACTAACAACCATGCTCAAGTGGGTGTCCGCCTCATCAACAGT
ATCAACCACTATGACCTGTTCATCGAGAGGTTCTGCATGACAGGTGGGAACAGCCCGATC
TGCTACCTCAAGGCCTATCACACCAACCTCTACTTGTCAGCCGATGCGGAAAAAGTGCGA
GAAGCCATTGATGAGGGGATCGCAGCTGCCACCATCTTCAGCCCCAGCAGGGATGTGGTT
GTGTCCCAGAGTCAGCTGCGCGTGGCCTTCGATGGGGACGCCGTGCTCTTCTCGGACGAG
TCGGAGCGCATCGTCAAGGCCCACGGGCTGGACCGATTCTTCGAGCATGAGAAGGCCCAC
GAGAACAAGCCTCTGGCTCAGGGCCCCTTAAAGGGCTTTCTGGAGGCACTGGGTAGGTTG
CAGAAGAAGTTCTACTCCAAAGGCCTGCGGCTGGAGTGCCCAATTCGTACCTACTTGGTG
ACAGCACGCAGTGCAGCCAGTTCCGGGGCCCGGGCTCTCAAGACCCTGCGCAGCTGGGGC
CTGGAGACAGATGAAGCCTTGTTCCTTGCTGGAGCGCCCAAGGGCCCTCTCCTTGAGAAG
ATCCGCCCACACATCTTCTTTGATGACCAGATGTTCCATGTGGCTGGGGCTCAGGAGATG
GGCACTGTGGCCGCCCATGTGCCTTATGGTGTGGCACAGACACCCCGGCGGACTGCACCT
GCAAAGCAGGCCCCATCTGCACAGTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF331801

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_2_Locus:
1p34.3-p33

# Metabolic_Enzyme_2_SNPs:
rs4660340; rs784611; rs752667; rs1180272; rs1180271; rs784595; rs873917; rs1568146; rs1535031; rs3851911; rs17264901; rs784596; rs12566856; rs12406284; rs11807200; rs784597; rs784610; rs734497; rs3806428; rs784600; rs11809004; rs7553293; rs3806433; rs16826428; rs9660121; rs784599; rs3806429; rs784612; rs1533479; rs2871601; rs41264507; rs34479837; rs12035327; rs1180270; rs9439008; rs35574502; rs34779558; rs36025518; rs36123767; rs35625235; rs28507686; rs35550484; rs11206573; rs41264509; rs784598; rs34604809; rs1535030; rs5773668; rs1517187; rs12039176; rs28592113; rs784594; rs9438930; rs11306359; rs35355327; rs6684666; rs34908371; rs28667717; rs3806432; rs5773667; rs7416372; rs34045723; rs6672154; rs35002774; rs35256759; rs3806431; rs12042601; rs10465833; rs1062103; rs10839; rs10888919; rs10888929; rs11206525; rs1180275; rs1180277; rs12039225; rs12042356; rs12565281; rs13315; rs16826440; rs17501838; rs17560858; rs2281302; rs2746057; rs3207766; rs3806434; rs3916165; rs6663003; rs6703320; rs704769; rs736009; rs7419080; rs784601; rs784602; rs784613; rs784615; rs784616; rs784627; rs784629; rs784630; rs813052

# Metabolic_Enzyme_2_General_References:
11133996

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5314

# Metabolic_Enzyme_3_Name:
Soluble calcium-activated nucleotidase 1

# Metabolic_Enzyme_3_Synonyms:
SCAN-1; Apyrase homolog; Putative NF-kappa-B-activating protein 107; Putative MAPK-activating protein PM09

# Metabolic_Enzyme_3_Gene_Name:
CANT1

# Metabolic_Enzyme_3_Protein_Sequence:
>Soluble calciumactivated nucleotidase 1
MPVQLSEHPEWNESMHSLRISVGGLPVLASMTKAADPRFRPRWKVILTFFVGAAILWLLC
SHRPAPGRPPTHNAHNWRLGQAPANWYNDTYPLSPPQRTPAGIRYRIAVIADLDTESRAQ
EENTWFSYLKKGYLTLSDSGDKVAVEWDKDHGVLESHLAEKGRGMELSDLIVFNGKLYSV
DDRTGVVYQIEGSKAVPWVILSDGDGTVEKGFKAEWLAVKDERLYVGGLGKEWTTTTGDV
VNENPEWVKVVGYKGSVDHENWVSNYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPR
RASQERYSEKDDERKGANLLLSASPDFGDIAVSHVGAVVPTHGFSSFKFIPNTDDQIIVA
LKSEEDSGRVASYIMAFTLDGRFLLPETKIGSVKYEGIEFI

# Metabolic_Enzyme_3_Number_of_Residues:
401

# Metabolic_Enzyme_3_Molecular_Weight:
44840

# Metabolic_Enzyme_3_Theoretical_pI:
5.98

# Metabolic_Enzyme_3_GO_Classification:
Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_3_Reaction:
A nucleoside diphosphate + H2O = a nucleotide + phosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF06079:Apyrase

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
45-62

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.6.1.6

# Metabolic_Enzyme_3_GenBank_ID_Protein:
22218108

# Metabolic_Enzyme_3_SwissProt_ID:
CANT1_HUMAN (Q8WVQ1)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
CANT1

# Metabolic_Enzyme_3_Geneatlas_id:
CANT1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:19721

# Metabolic_Enzyme_3_PDB_ID:
1S1D

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Intracytoplasmic membrane; single-pass type II membrane protein. Processed form:Secreted protein

# Metabolic_Enzyme_3_Gene_Sequence:
>1116 bp
ATGACCAAGGCCGCGGACCCCCGCTTCCGCCCCCGCTGGAAGGTGATCCTGACGTTCTTT
GTGGGTGCTGCCATCCTCTGGCTGCTCTGCTCCCACCGCCCGGCCCCCGGCAGGCCCCCC
ACCCACAATGCACACAACTGGAGGCTCGGCCAGGCGCCCGCCAACTGGTACAATGACACC
TACCCCCTGTCTCCCCCACAAAGGACACCGGCTGGGATTCGGTATCGAATCGCAGTTATC
GCAGACCTGGACACAGAGTCAAGGGCCCAAGAGGAAAACACCTGGTTCAGTTACCTGAAA
AAGGGCTACCTGACCCTGTCAGACAGTGGGGACAAGGTGGCCGTGGAATGGGACAAAGAC
CATGGGGTCCTGGAGTCCCACCTGGCGGAGAAGGGGAGAGGCATGGAGCTATCCGACCTG
ATTGTTTTCAATGGGAAACTCTACTCCGTGGATGACCGGACGGGGGTCGTCTACCAGATC
GAAGGCAGCAAAGCCGTGCCCTGGGTGATTCTGTCCGACGGCGACGGCACCGTGGAGAAA
GGCTTCAAGGCCGAATGGCTGGCAGTGAAGGACGAGCGTCTGTACGTGGGCGGCCTGGGC
AAGGAGTGGACGACCACTACGGGTGATGTGGTGAACGAGAACCCGGAGTGGGTGAAGGTG
GTGGGCTACAAGGGCAGCGTGGACCACGAGAACTGGGTGTCCAACTACAACGCCCTGCGG
GCTGCTGCCGGCATCCAGCCGCCAGGCTACCTCATCCATGAGTCTGCCTGCTGGAGTGAC
ACGCTGCAGCGCTGGTTCTTCCTGCCGCGCCGCGCCAGCCAGGAGCGCTACAGCGAGAAG
GACGACGAGCGCAAGGGCGCCAACCTGCTGCTGAGCGCCTCCCCTGACTTCGGCGACATC
GCTGTGAGCCACGTCGGGGCGGTGGTCCCCACTCACGGCTTCTCGTCCTTCAAGTTCATC
CCCAACACCGACGACCAGATCATTGTGGCCCTCAAATCCGAGGAGGACAGCGGCAGAGTC
GCCTCCTACATCATGGCCTTCACGCTGGACGGGCGCTTCCTGTTGCCGGAGACCAAGATC
GGAAGCGTGAAATACGAAGGCATCGAGTTCATTTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
AF328554

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_3_Locus:
17q25.3

# Metabolic_Enzyme_3_SNPs:
rs8077024; rs35290882; rs35324359; rs2377301; rs9916285; rs3744171; rs4789903; rs9896857; rs4789848; rs12450407; rs7214331; rs12450128; rs4789847; rs4861; rs11891; rs17739056; rs12452918; rs3744173; rs12949479; rs16971940; rs8079368; rs4789904; rs9904301; rs3744170; rs12452876; rs3744168; rs9915230; rs12452980; rs12451303; rs11546278; rs34082669; rs9903215; rs3803781; rs1127654; rs34461224; rs2377010; rs5017245; rs34435616; rs5017244; rs35308608; rs35755919; rs7219932; rs28627413; rs8078860; rs34996994; rs12936828; rs9899883; rs35356398; rs34938499; rs5017243; rs34572362; rs14791; rs4789849; rs34891215; rs2377009; rs34097366; rs35738150; rs5017242; rs3038740; rs35518955; rs9891726; rs3744169; rs12939358; rs12939350; rs12939399; rs4497730; rs6501274; rs9914188

# Metabolic_Enzyme_3_General_References:
12234496; 12761501; 12167635

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
6159

# Metabolic_Enzyme_4_Name:
Ectonucleoside triphosphate diphosphohydrolase 4

# Metabolic_Enzyme_4_Synonyms:
NTPDase 4; Uridine-diphosphatase; UDPase; Lysosomal apyrase-like protein of 70 kDa

# Metabolic_Enzyme_4_Gene_Name:
ENTPD4

# Metabolic_Enzyme_4_Protein_Sequence:
>Ectonucleoside triphosphate diphosphohydrolase 4
MGRIGISCLFPASWHFSISPVGCPRILNTNLRQIMVISVLAAAVSLLYFSVVIIRNKYGR
LTRDKKFQRYLARVTDIEATDTNNPNVNYGIVVDCGSSGSRVFVYCWPRHNGNPHDLLDI
RQMRDKNRKPVVMKIKPGISEFATSPEKVSDYISPLLNFAAEHVPRAKHKETPLYILCTA
GMRILPESQQKAILEDLLTDIPVHFDFLFSDSHAEVISGKQEGVYAWIGINFVLGRFEHI
EDDDEAVVEVNIPGSESSEAIVRKRTAGILDMGGVSTQIAYEVPKTVSFASSQQEEVAKN
LLAEFNLGCDVHQTEHVYRVYVATFLGFGGNAARQRYEDRIFANTIQKNRLLGKQTGLTP
DMPYLDPCLPLDIKDEIQQNGQTIYLRGTGDFDLCRETIQPFMNKTNETQTSLNGVYQPP
IHFQNSEFYGFSEFYYCTEDVLRMGGDYNAAKFTKAAKDYCATKWSILRERFDRGLYASH
ADLHRLKYQCFKSAWMFEVFHRGFSFPVNYKSLKTALQVYDKEVQWTLGAILYRTRFLPL
RDIQQEAFRASHTHWRGVSFVYNHYLFSGCFLVVLLAILLYLLRLRRIHRRTPRSSSAAA
LWMEEGLPAQNAPGTL

# Metabolic_Enzyme_4_Number_of_Residues:
616

# Metabolic_Enzyme_4_Molecular_Weight:
70256

# Metabolic_Enzyme_4_Theoretical_pI:
8.39

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP

# Metabolic_Enzyme_4_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_4_Reaction:
A nucleoside diphosphate + H2O = a nucleotide + phosphate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01150:GDA1_CD39

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
34-54
560-580

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.6.1.6

# Metabolic_Enzyme_4_GenBank_ID_Protein:
3153211

# Metabolic_Enzyme_4_SwissProt_ID:
ENTP4_HUMAN (Q9Y227)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
ENTPD4

# Metabolic_Enzyme_4_Geneatlas_id:
ENTPD4

# Metabolic_Enzyme_4_hgnc_id:
HGNC:14573

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential). Note=Localizes in the Golgi and autophagic vacuoles/lysosomes

# Metabolic_Enzyme_4_Gene_Sequence:
>1830 bp
ATGGGGAGGATTGGCATCTCCTGTCTTTTTCCTGCTTCTTGGCATTTTAGCATATCTCCA
GTAGGGTGTCCTCGAATTCTGAATACCAATTTACGCCAAATTATGGTCATTAGTGTCCTG
GCTGCTGCTGCTGTTTCACTTTTATATTTTTCTGTTGTCATAATCCGAAATAAGTATGGG
CGACTAACCAGAGACAAGAAATTTCAAAGGTACCTGGCACGAGTTACCGACATTGAAGCT
ACAGACACCAATAACCCCAATGTGAACTATGGGATCGTGGTGGACTGTGGTAGCAGTGGG
TCTCGAGTATTTGTTTACTGCTGGCCAAGGCATAATGGCAATCCACATGATCTGTTGGAT
ATCAGGCAAATGAGGGATAAAAACCGAAAGCCAGTGGTCATGAAGATAAAACCGGGCATT
TCAGAATTTGCTACCTCTCCAGAGAAAGTCAGTGATTACATTTCTCCACTTTTGAACTTT
GCTGCAGAGCATGTGCCACGGGCAAAACACAAAGAGACACCTCTCTACATTCTCTGCACG
GCTGGAATGAGAATCCTCCCCGAAAGCCAGCAGAAAGCTATTCTGGAAGACCTTCTGACC
GATATCCCCGTGCACTTTGACTTTCTGTTTTCTGACTCTCATGCAGAAGTAATTTCTGGG
AAACAAGAAGGTGTGTATGCTTGGATTGGCATTAATTTTGTCCTTGGACGATTTGAGCAT
ATTGAAGATGATGATGAGGCCGTTGTGGAAGTTAACATTCCTGGAAGTGAAAGCAGCGAA
GCCATTGTCCGTAAAAGGACAGCGGGCATTCTCGACATGGGCGGCGTGTCGACTCAGATA
GCGTACGAAGTCCCCAAAACTGAAGAAGTAGCTAAAAACTTGTTAGCTGAATTTAACTTG
GGATGTGATGTTCACCAAACTGAGCATGTGTATCGAGTCTATGTGGCCACGTTTCTTGGG
TTTGGTGGCAATGCTGCTCGACAGAGATACGAAGACAGAATATTTGCCAACACCATTCAA
AAGAACAGGCTCCTGGGTAAACAGACTGGTCTGACTCCTGATATGCCGTACTTGGACCCC
TGCCTACCCCTAGACATTAAAGATGAAATCCAGCAAAATGGACAAACCATATACCTACGA
GGGACTGGAGACTTTGACCTGTGTCGAGAGACTATCCAGCCTTTCATGAATAAAACAAAC
GAGACCCAGACTTCCCTCAATGGGGTCTACCAGCCCCCAATTCACTTCCAGAACAGTGAA
TTCTATGGCTTCTCCGAATTCTACTACTGCACCGAGGATGTGTTACGAATGGGGGGAGAC
TACAATGCTGCTAAATTTACTAAAGCTGCAAAGGATTACTGTGCAACAAAGTGGTCCATT
TTGCGGGAACGCTTTGACCGAGGACTGTACGCCTCTCATGCTGACCTCCACAGGCTTAAG
TATCAGTGCTTCAAATCGGCCTGGATGTTTGAGGTGTTTCATAGGGGCTTTTCGTTTCCT
GTCAACTATAAAAGCTTAAAGACTGCCTTGCAAGTTTACGACAAGGAGGTTCAGTGGACC
CTTGGAGCCATCCTCTACAGGACCCGCTTTCTACCATTAAGAGACATCCAGCAGGAGGCC
TTCCGAGCCAGTCACACCCACTGGCGGGGCGTTTCCTTTGTCTACAACCACTACCTGTTC
TCTGGCTGCTTCCTGGTGGTGCTGCTGGCCATCCTGCTGTACCTGCTGCGGCTGCGGCGC
ATCCACAGGCGCACTCCCCGGAGCAGCTCGGCCGCCGCCCTCTGGATGGAGGAGGGCCTT
CCCGCCCAGAATGCCCCAGGGACCTTGTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF016032

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_4_Locus:
8p21.3

# Metabolic_Enzyme_4_SNPs:
rs2272641; rs3736652; rs17089244; rs1142283; rs35942025; rs6557673; rs11991860; rs10111621; rs9987295; rs11784720; rs4872135; rs11777391; rs10088178; rs6993786; rs12549049; rs11998306; rs6997747; rs34309579; rs11135738; rs11779731; rs3817676; rs11787224; rs2272642; rs2272643; rs2280832; rs2293936; rs17089269; rs3736021; rs12678121; rs12549539; rs12675817; rs2272640; rs7822769; rs17089263; rs17089265; rs17697423; rs17088182; rs12675370; rs17089262; rs17089274; rs7842651; rs4872137; rs7843529; rs1061293; rs17089243; rs17089242; rs10113258; rs34849865; rs7834525; rs34270448; rs34632200; rs34073541; rs34848683; rs10089929; rs3115079; rs3115793; rs1012102; rs10108137; rs36083369; rs3115063; rs36098102; rs3115797; rs34640760; rs28850707; rs34914268; rs28461549; rs3115792; rs12544395; rs3115795; rs34670900; rs34845265; rs35780459; rs13258589; rs3115080; rs3115078; rs35708289; rs36124058; rs11775550; rs28583707; rs35066759; rs3115796; rs35289255; rs3115798; rs34327033; rs3115794; rs34616483; rs3115064; rs36099859; rs11460993; rs35719007; rs4872136; rs3115802; rs17769774; rs35664894; rs35266948; rs35064940; rs35118096; rs34022555; rs3808529; rs3115800; rs35646971; rs35141884; rs3115062; rs28546748; rs3115799; rs28637894; rs13258314; rs34457534; rs3115060; rs3779896; rs34436580; rs3115061; rs6991696; rs4571739; rs3115801; rs34006522; rs34615023; rs10582272; rs5890111; rs3115065; rs11419889; rs33928899; rs11403204; rs11373073; rs3115066; rs34507802; rs34232820; rs1138445; rs35899973; rs10099856; rs1064960; rs11135737; rs11779953; rs11785006; rs11984809; rs11991420; rs11995954; rs11996137; rs12545040; rs13248759; rs13250995; rs13259746; rs13260722; rs17089226; rs17089234; rs17697763; rs2977449; rs3115067; rs4872130; rs4872131; rs4872133; rs4872134; rs6557672; rs6557674; rs6983320; rs7832251; rs7833173; rs7846081

# Metabolic_Enzyme_4_General_References:
9556635; 10393803; 10858452; 9205841

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
6160

# Metabolic_Enzyme_5_Name:
Ectonucleoside triphosphate diphosphohydrolase 6

# Metabolic_Enzyme_5_Synonyms:
NTPDase 6; CD39 antigen-like 2

# Metabolic_Enzyme_5_Gene_Name:
ENTPD6

# Metabolic_Enzyme_5_Protein_Sequence:
>Ectonucleoside triphosphate diphosphohydrolase 6
MKKGIRYETSRKTSYIFQQPQHGPWQTRMRKISNHGSLRVAKVAYPLGLCVGVFIYVAYI
KWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQF
TRPPRETPTLTHETFKALKPGLSAYADDVEKSAQGIRELLDVAKQDIPFDFWKATPLVLK
ATAGLRLLPGEKAQKLLQKVKEVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLK
TPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLM
SARLAILGGVEGQPAKDGKELVSPCLSPSFKGEWEHAEVTYRVSGQKAAASLHELCAARV
SEVLQNRVHRTEEVKHVDFYAFSYYYDLAAGVGLIDAEKGGSLVVGDFEIAAKYVCRTLE
TQPQSSPFSCMDLTYVSLLLQEFGFPRSKVLKLTRKIDNVETSWALGAIFHYIDSLNRQK
SPAS

# Metabolic_Enzyme_5_Number_of_Residues:
484

# Metabolic_Enzyme_5_Molecular_Weight:
53248

# Metabolic_Enzyme_5_Theoretical_pI:
9.52

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5'-monophosphates. The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP

# Metabolic_Enzyme_5_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_5_Reaction:
A nucleoside diphosphate + H2O = a nucleotide + phosphate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01150:GDA1_CD39

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
40-60

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.6.1.6

# Metabolic_Enzyme_5_GenBank_ID_Protein:
3335098

# Metabolic_Enzyme_5_SwissProt_ID:
ENTP6_HUMAN (O75354)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ENTPD6

# Metabolic_Enzyme_5_Geneatlas_id:
ENTPD6

# Metabolic_Enzyme_5_hgnc_id:
HGNC:3368

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein. Secreted protein. Note=But also occurs in a soluble extracellular form

# Metabolic_Enzyme_5_Gene_Sequence:
>1455 bp
ATGAAAAAAGGTATCCGTTATGAAACTTCCAGAAAAACGAGCTACATTTTTCAGCAGCCG
CAGCACGGTCCTTGGCAAACAAGGATGAGAAAAATATCCAACCACGGGAGCCTGCGGGTG
GCGAAGGTGGCATACCCCCTGGGGCTGTGTGTGGGCGTGTTCATCTATGTTGCCTACATC
AAGTGGCACCGGGCCACCGCCACCCAGGCCTTCTTCAGCATCACCAGGGCAGCCCCGGGG
GCCCGGTGGGGTCAGCAGGCCCACAGCCCCCTGGGGACAGCTGCAGACGGGCACGAGGTC
TTCTACGGGATCATGTTTGATGCAGGAAGCACTGGCACCCGAGTACACGTCTTCCAGTTC
ACCCGGCCCCCCAGAGAAACTCCCACGTTAACCCACGAAACCTTCAAAGCAGTGAAGCCA
GGTCTTTCTGCCTATGCTGATGATGTTGAAAAGAGCGCTCAGGGAATCCGGGAACTACTG
GATGTTGCTAAACAGGACATTCCGTTCGACTTCTGGAAGGCCACCCCTCTGGTCCTCAAG
GCCACAGCTGGCTTACGCCTGTTACCTGGAGAAAAGGCCCAGAAGTTACTGCAGAAGGTG
AAAGAAGTATTTAAAGCATCGCCTTTCCTTGTAGGGGATGACTGTGTTTCCATCATGAAC
GGAACAGATGAAGGCGTTTCGGCGTGGATCACCATCAACTTCCTGACAGGCAGCTTGAAA
ACTCCAGGAGGGAGCAGCGTGGGCATGCTGGACTTGGGCGGAGGATCCACTCAGATCGCC
TTCCTGCCACGCGTGGAGGGCACCCTGCAGGCCTCCCCACCCGGCTACCTGACGGCACTG
CGGATGTTTAACAGGACCTACAAGCTCTATTCCTACAGCTACCTCGGGCTCGGGCTGATG
TCGGCACGCCTGGCGATCCTGGGCGGCGTGGAGGGGCAGCCTGCTAAGGATGGAAAGGAG
TTGGTCAGCCCTTGCTTGTCTCCCAGTTTCAAAGGAGAGTGGGAACACGCAGAAGTCACG
TACAGGGTTTCAGGGCAGAAAGCAGCGGCAAGCCTGCACGAGCTGTGTGCTGCCAGAGTG
TCAGAGGTCCTTCAAAACAGAGTGCACAGGACGGAGGAAGTGAAGCATGTGGACTTCTAT
GCTTTCTCCTACTATTACGACCTTGCAGCTGGTGTGGGCCTCATAGATGCGGAGAAGGGA
GGCAGCCTGGTGGTGGGGGACTTCGAGATCGCAGCCAAGTACGTGTGTCGGACCCTGGAG
ACACAGCCGCAGAGCAGCCCCTTCTCATGCATGGACCTCACCTACGTCAGCCTGCTACTC
CAGGAGTTCGGCTTTCCCAGGAGCAAAGTGCTGAAGCTCACTCGGAAAATTGACAATGTT
GAGACCAGCTGGGCTCTGGGGGCCATTTTTCATTACATCGACTCCCTGAACAGACAGAAG
AGTCCAGCCTCATAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AF039916

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_5_Locus:
20p11.2-p11.22

# Metabolic_Enzyme_5_SNPs:
rs6050446; rs2076559; rs34007133; rs2076561; rs6037057; rs2387733; rs1473695; rs6050425; rs6050426; rs6083776; rs6037064; rs2268879; rs6050429; rs6083774; rs6050428; rs1044573; rs6138537; rs11698185; rs7453; rs6037056; rs6037058; rs6138535; rs1473694; rs12480022; rs6050431; rs2268880; rs6050432; rs6050427; rs6083777; rs6050459; rs6050422; rs6115083; rs2179638; rs6037062; rs1007708; rs6050445; rs6050456; rs11699316; rs3787076; rs1980497; rs3787077; rs6050447; rs6050438; rs2073077; rs6083780; rs8122855; rs1007707; rs6050448; rs6037060; rs6050439; rs6083781; rs11699392; rs12479688; rs2076560; rs6115090; rs6138539; rs6050436; rs6050442; rs6037061; rs6115089; rs11906864; rs12106059; rs11906892; rs4815394; rs6037059; rs8115509; rs11699328; rs6050450; rs13039195; rs4456769; rs6115080; rs6138542; rs4815392; rs6115079; rs4815391; rs6115092; rs6050462; rs6138541; rs1044567; rs35296506; rs35185820; rs1044566; rs17852319; rs36118080; rs34363734; rs6115085; rs11539326; rs11699401; rs6138536; rs6132818; rs34312852; rs6115084; rs3831863; rs34540874; rs6037063; rs6115081; rs34400168; rs6050423; rs11699400; rs4637196; rs8183951; rs36006648; rs3787075; rs10534876; rs34001350; rs11468275; rs41297634; rs1044577; rs6050460; rs6115086; rs35386002; rs35056043; rs6037055; rs6138534; rs3216638; rs36041064; rs3203849; rs41310173; rs6083775; rs6050424; rs35444749; rs3180935; rs6050430; rs6050461; rs35167117; rs13038578; rs41308080; rs34981146; rs6083779; rs6115088; rs41308643; rs34491307; rs11699248; rs36120442; rs11087505; rs6050437; rs35547579; rs35387656; rs6083782; rs11474912; rs6050434; rs6050457; rs6050449; rs35880604; rs34833673; rs4815393; rs6050452; rs6050453; rs11481940; rs33998706; rs6050440; rs6050451; rs6115091; rs6050443; rs6076325; rs6050441; rs6138538; rs6050435; rs7345402; rs6050454; rs6050458; rs6050444; rs34893522; rs6115087; rs3215556; rs6083772; rs6083773; rs41282326; rs6083783; rs8125833; rs6132817; rs35417018; rs11699219; rs12373881; rs12480898; rs2067793; rs3746337; rs6037053; rs6050414; rs6050418; rs6050466; rs6083784; rs6107015; rs6115076; rs6115077; rs6115093; rs6115094; rs6132816; rs6138531; rs6138532; rs6138547; rs8115257

# Metabolic_Enzyme_5_General_References:
9676430; 11780052; 11041856

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5951

# Metabolic_Enzyme_6_Name:
GMP reductase 2

# Metabolic_Enzyme_6_Synonyms:
Guanosine 5'-monophosphate oxidoreductase 2; Guanosine monophosphate reductase 2

# Metabolic_Enzyme_6_Gene_Name:
GMPR2

# Metabolic_Enzyme_6_Protein_Sequence:
>GMP reductase 2
MPHIDNDVKLDFKDVLLRPKRSTLKSRSEVDLTRSFSFRNSKQTYSGVPIIAANMDTVGT
FEMAKVLCKFSLFTAVHKHYSLVQWQEFAGQNPDCLEHLAASSGTGSSDFEQLEQILEAI
PQVKYICLDVANGYSEHFVEFVKDVRKRFPQHTIMAGNVVTGEMVEELILSGADIIKVGI
GPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVM
LGGMLAGHSESGGELIERDGKKYKLFYGMSSEMAMKKYAGGVAEYRASEGKTVEVPFKGD
VEHTIRDILGGIRSTCTYVGAAKLKELSRRTTFIRVTQQVNPIFSEAC

# Metabolic_Enzyme_6_Number_of_Residues:
348

# Metabolic_Enzyme_6_Molecular_Weight:
37875

# Metabolic_Enzyme_6_Theoretical_pI:
7.25

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on NADH or NADPH
Function:  oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor
Function:  GMP reductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation

# Metabolic_Enzyme_6_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_6_Reaction:
inosine 5'-phosphate + ammonia + NADP+ = guanosine 5'-phosphate + NADPH + H+

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00478:IMPDH

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.7.1.7

# Metabolic_Enzyme_6_GenBank_ID_Protein:
23451216

# Metabolic_Enzyme_6_SwissProt_ID:
GMPR2_HUMAN (Q9P2T1)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
GMPR2

# Metabolic_Enzyme_6_Geneatlas_id:
GMPR2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:4377

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>1047 bp
ATGCCTCATATTGACAACGATGTGAAACTGGACTTCAAGGATGTCCTTTTGAGGCCCAAA
CGCAGTACCCTTAAGTCTCGAAGTGAGGTGGATCTCACAAGATCCTTTTCATTTCGGAAC
TCAAAGCAGACATACTCTGGGGTTCCCATCATTGCTGCCAATATGGATACTGTGGGCACC
TTTGAGATGGCCAAGGTTCTCTGTAAGTTCTCTCTCTTCACTGCTGTCCATAAGCACTAT
AGCCTCGTTCAGTGGCAAGAGTTTGCTGGCCAGAATCCTGACTGTCTTGAGCATCTGGCT
GCCAGCTCAGGCACAGGCTCTTCTGACTTTGAGCAGCTGGAACAGATCCTGGAAGCTATT
CCCCAGGTGAAGTATATATGCCTGGATGTGGCAAATGGCTACTCTGAACACTTTGTTGAA
TTTGTAAAAGATGTACGGAAGCGCTTCCCCCAGCACACCATCATGGCAGGGAATGTGGTA
ACAGGAGAGATGGTAGAAGAGCTCATCCTTTCTGGGGCTGACATCATCAAAGTGGGAATT
GGGCCAGGCTCTGTGTGTACTACTCGGAAGAAAACTGGAGTGGGGTATCCACAGCTCAGC
GCAGTGATGGAGTGTGCAGATGCTGCTCATGGCCTCAAAGGCCACATCATTTCAGATGGA
GGTTGCAGCTGTCCTGGGGATGTGGCCAAGGCTTTTGGGGCAGGAGCTGACTTCGTGATG
CTGGGTGGCATGCTGGCTGGGCACAGTGAGTCAGGTGGTGAGCTCATCGAGAGGGATGGC
AAGAAGTACAAGCTCTTCTATGGAATGAGTTCTGAAATGGCCATGAAGAAGTATGCTGGG
GGCGTGGCTGAGTACAGAGCCTCAGAGGGAAAGACAGTGGAAGTTCCTTTTAAAGGAGAT
GTGGAACATACCATCCGAGACATCCTAGGAGGGATCCGCTCTACGTGTACCTATGTGGGA
GCAGCTAAGCTCAAAGAGTTGAGCAGGAGAACTACCTTCATCCGAGTCACCCAGCAGGTG
AATCCAATCTTCAGTGAGGCGTGCTAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AF419346

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_6_Locus:
14q12

# Metabolic_Enzyme_6_SNPs:
rs34354104; rs2273304; rs12891162; rs17102265; rs1950496; rs2273305; rs11540864; rs1142733; rs17102232; rs4624073; rs34469605; rs1950495; rs10134804; rs10138628; rs10141326; rs10148135; rs11158615; rs11625433; rs11844422; rs12883582; rs12897704; rs17102177; rs17102311; rs17102313; rs17794752; rs2144487; rs2295316; rs2332229; rs34113897; rs3814815; rs4982877; rs7145550; rs7152342; rs7157595; rs7158744; rs766601; rs766602; rs8193035

# Metabolic_Enzyme_6_General_References:
12009299

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5236

# Metabolic_Enzyme_7_Name:
5'(3')-deoxyribonucleotidase, mitochondrial precursor

# Metabolic_Enzyme_7_Synonyms:
5',3'-nucleotidase, mitochondrial; Deoxy-5'-nucleotidase 2; dNT-2

# Metabolic_Enzyme_7_Gene_Name:
NT5M

# Metabolic_Enzyme_7_Protein_Sequence:
>5'3'deoxyribonucleotidase, mitochondrial precursor
MIRLGGWCARRLCSAAVPAGRRGAAGGLGLAGGRALRVLVDMDGVLADFEGGFLRKFRAR
FPDQPFIALEDRRGFWVSEQYGRLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMAS
LQNTDVFICTSPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDI
TGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRPC

# Metabolic_Enzyme_7_Number_of_Residues:
228

# Metabolic_Enzyme_7_Molecular_Weight:
25862

# Metabolic_Enzyme_7_Theoretical_pI:
8.12

# Metabolic_Enzyme_7_GO_Classification:
Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
Not Available

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_7_Signals:
1-15

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_7_GenBank_ID_Protein:
9408106

# Metabolic_Enzyme_7_SwissProt_ID:
NT5M_HUMAN (Q9NPB1)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
NT5M

# Metabolic_Enzyme_7_Geneatlas_id:
NT5M

# Metabolic_Enzyme_7_hgnc_id:
HGNC:15769

# Metabolic_Enzyme_7_PDB_ID:
1Q92

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_7_Gene_Sequence:
>687 bp
ATGATCCGGCTGGGCGGCTGGTGTGCGCGGCGGCTCTGCAGCGCGGCGGTTCCCGCGGGG
CGGCGCGGGGCGGCGGGCGGGCTGGGCCTGGCGGGAGGCCGCGCCCTACGGGTGCTGGTG
GACATGGACGGCGTGCTGGCTGACTTCGAGGGCGGATTCCTCAGGAAGTTCCGCGCGCGC
TTTCCCGACCAGCCCTTCATCGCGCTGGAGGACCGGCGCGGCTTCTGGGTGTCGGAGCAG
TACGGCCGCCTGCGGCCAGGGCTGAGCGAGAAGGCCATCAGCATTTGGGAGTCAAAGAAT
TTCTTTTTTGAACTTGAGCCTCTGCCAGGGGCCGTGGAAGCTGTCAAGGAGATGGCCAGC
CTACAAAACACTGACGTCTTCATCTGCACAAGCCCCATCAAGATGTTCAAGTACTGTCCC
TATGAGAAGTATGCCTGGGTGGAGAAGTACTTTGGCCCTGACTTTCTGGAGCAGATTGTG
CTGACCAGAGACAAGACCGTGGTCTCTGCTGACCTTCTCATAGACGACCGGCCGGACATC
ACAGGGGCCGAGCCAACCCCCAGCTGGGAGCATGTCCTCTTCACCGCCTGCCACAACCAG
CACCTGCAGCTGCAGCCCCCCCGCCGCAGGCTGCACTCGTGGGCGGACGACTGGAAGGCC
ATTCTGGACAGCAAGCGGCCCTGCTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AJ277557

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_7_Locus:
17p11.2

# Metabolic_Enzyme_7_SNPs:
rs2240876; rs758742; rs1860553; rs242243; rs6502579; rs7223473; rs11078384; rs7226068; rs10468464; rs12948296; rs1860552; rs9912109; rs9898622; rs7211968; rs17726703; rs9914692; rs3785502; rs11867932; rs3785504; rs17726673; rs11654778; rs16942153; rs17726858; rs11078382; rs3826302; rs2064060; rs6502580; rs7217503; rs9912172; rs3785506; rs9908168; rs11652902; rs9902505; rs4985707; rs6502576; rs6502578; rs16961564; rs7210344; rs16961516; rs242242; rs171394; rs12600778; rs9909111; rs7219752; rs6502577; rs12601631; rs11869054; rs17726924; rs9891799; rs11870836; rs11869507; rs11078383; rs4985706; rs7217162; rs9889738; rs9908338; rs7222555; rs9915883; rs7211243; rs9916133; rs9907857; rs9905836; rs11657817; rs9889298; rs7220829; rs9903425; rs9908360; rs9914424; rs9908124; rs11650700; rs11869079; rs7212369; rs9889367; rs7217114; rs9896977; rs9916676; rs16961561; rs12602026; rs9896970; rs9904396; rs9909850; rs10852849; rs11078385; rs6502575; rs242244; rs16961576; rs3203918; rs8082383; rs7212012; rs36114962; rs9889834; rs7226045; rs12602003; rs9894669; rs35712658; rs12941075; rs7210625; rs35320589; rs11655849; rs35470335; rs34668117; rs12943271; rs34446504; rs35945070; rs34219219; rs12951176; rs35554631; rs34408375; rs28825184; rs7218566; rs35917484; rs28880443; rs9904393; rs12601106; rs34579357; rs4985765; rs9907711; rs11343472; rs35579933; rs3087093; rs12951985; rs34993127; rs36088408; rs36091965; rs34100977; rs7220057; rs8080335; rs9901325; rs35720826; rs34886391; rs12949216; rs9898993; rs34121330; rs34513135; rs12936127; rs8067236; rs8081939; rs10617184; rs7211790; rs9914209; rs12951519; rs12603230; rs9913775; rs8068408; rs12452455; rs9901373; rs3063349; rs9913682; rs3785503; rs34156759; rs34776810; rs10574223; rs34836173; rs12951434; rs9709057; rs28813401; rs36146846; rs34709982; rs28616155; rs8082379; rs35267848; rs12951289; rs12948357; rs12950577; rs35861887; rs12948747; rs35096596; rs8080408; rs9898042; rs35930947; rs12948751; rs5741757; rs9889355; rs35575792; rs34018072; rs34407368; rs4985764; rs11395505; rs34676851; rs12951504; rs12950929; rs34025151; rs3837806; rs34247865; rs12946386; rs34209605; rs7219953; rs12951983; rs11400183; rs9912599; rs36056059; rs8071972; rs35039203; rs35326975; rs8071718; rs12946113; rs1009720; rs10852850; rs11078381; rs11078386; rs11871699; rs12450758; rs12451886; rs12452946; rs12602578; rs16961593; rs16961599; rs17648393; rs183596; rs190261; rs2041393; rs2058292; rs2191383; rs242246; rs242247; rs242249; rs242250; rs242251; rs624242; rs6502572; rs8067390; rs9892592; rs9899615; rs9905458; rs9909800; rs9914113

# Metabolic_Enzyme_7_General_References:
10899995; 12352955

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5229

# Metabolic_Enzyme_8_Name:
5'-nucleotidase precursor

# Metabolic_Enzyme_8_Synonyms:
Ecto-5'-nucleotidase; 5'-NT; CD73 antigen

# Metabolic_Enzyme_8_Gene_Name:
NT5E

# Metabolic_Enzyme_8_Protein_Sequence:
>5'nucleotidase precursor
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ

# Metabolic_Enzyme_8_Number_of_Residues:
574

# Metabolic_Enzyme_8_Molecular_Weight:
63368

# Metabolic_Enzyme_8_Theoretical_pI:
7.04

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  hydrolase activity, acting on ester bonds
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides

# Metabolic_Enzyme_8_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_8_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF02872:5_nucleotid_C;
PF00149:Metallophos

# Metabolic_Enzyme_8_Signals:
1-26

# Metabolic_Enzyme_8_Transmembrane_Regions:
556-573

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_8_GenBank_ID_Protein:
23897

# Metabolic_Enzyme_8_SwissProt_ID:
5NTD_HUMAN (P21589)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
NT5E

# Metabolic_Enzyme_8_Geneatlas_id:
NT5E

# Metabolic_Enzyme_8_hgnc_id:
HGNC:8021

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Metabolic_Enzyme_8_Gene_Sequence:
>1725 bp
ATGTGTCCCCGAGCCGCGCGGGCGCCCGCGACGCTACTCCTCGCCCTGGGCGCGGTGCTG
TGGCCTGCGGCTGGCGCCTGGGAGCTTACGATTTTGCACACCAACGACGTGCACAGCCGG
CTGGAGCAGACCAGCGAGGACTCCAGCAAGTGCGTCAACGCCAGCCGCTGCATGGGTGGC
GTGGCTCGGCTCTTCACCAAGGTTCAGCAGATCCGCCGCGCCGAACCCAACGTGCTGCTG
CTGGACGCCGGCGACCAGTACCAGGGCACTATCTGGTTCACCGTGTACAAGGGCGCCGAG
GTGGCGCACTTCATGAACGCCCTGCGCTACGATGCCATGGCACTGGGAAATCATGAATTT
GATAATGGTGTGGAAGGACTGATCGAGCCACTCCTCAAAGAGGCCAAATTTCCAATTCTG
AGTGCAAACATTAAAGCAAAGGGGCCACTAGCATCTCAAATATCAGGACTTTATTTGCCA
TATAAAGTTCTTCCTGTTGGTGATGAAGTTGTGGGAATCGTTGGATACACTTCCAAAGAA
ACCCCTTTTCTCTCAAATCCAGGGACAAATTTAGTGTTTGAAGATGAAATCACTGCATTA
CAACCTGAAGTAGATAAGTTAAAAACTCTAAATGTGAACAAAATTATTGCACTGGGACAT
TCGGGTTTTGAAATGGATAAACTCATCGCTCAGAAAGTGAGGGGTGTGGACGTCGTGGTG
GGAGGACACTCCAACACATTTCTTTACACAGGCAATCCACCTTCCAAAGAGGTGCCTGCT
GGGAAGTACCCATTCATAGTCACTTCTGATGATGGGCGGAAGGTTCCTGTAGTCCAGGCC
TATGCTTTTGGCAAATACCTAGGCTATCTGAAGATCGAGTTTGATGAAAGAGGAAACGTC
ATCTCTTCCCATGGAAATCCCATTCTTCTAAACAGCAGCATTCCTGAAGATCCAAGCATA
AAAGCAGACATTAACAAATGGAGGATAAAATTGGATAATTATTCTACCCAGGAATTAGGG
AAAACAATTGTCTATCTGGATGGCTCCTCTCAATCATGCCGCTTTAGAGAATGCAACATG
GGCAACCTGATTTGTGATGCAATGATTAACAACAACCTGAGACACACGGATGAAATGTTC
TGGAACCACGTATCCATGTGCATTTTAAATGGAGGTGGTATCCGGTCGCCCATTGATGAA
CGCAACAATGGCACAATTACCTGGGAGAACCTGGCTGCTGTATTGCCCTTTGGAGGCACA
TTTGACCTAGTCCAGTTAAAAGGTTCCACCCTGAAGAAGGCCTTTGAGCATAGCGTGCAC
CGCTACGGCCAGTCCACTGGAGAGTTCCTGCAGGTGGGCGGAATCCATGTGGTGTATGAT
CTTTCCCGAAAACCTGGAGACAGAGTAGTCAAATTAGATGTTCTTTGCACCAAGTGTCGA
GTGCCCAGTTATGACCCTCTCAAAATGGACGAGGTATATAAGGTGATCCTCCCAAACTTC
CTGGCCAATGGTGGAGATGGGTTCCAGATGATAAAAGATGAATTATTAAGACATGACTCT
GGTGACCAAGATATCAACGTGGTTTCTACATATATCTCCAAAATGAAAGTAATTTATCCA
GCAGTTGAAGGTCGGATCAAGTTTTCCACAGGAAGTCACTGCCATGGAAGCTTTTCTTTA
ATATTTCTTTCACTTTGGGCAGTGATCTTTGTTTTATACCAATAG

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X55740

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_8_Locus:
6q14-q21

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
2129526; 8566797; 2173922; 9651114

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
6161

# Metabolic_Enzyme_9_Name:
Ectonucleoside triphosphate diphosphohydrolase 5 precursor

# Metabolic_Enzyme_9_Synonyms:
NTPDase 5; Nucleoside diphosphatase; CD39 antigen-like 4; ER-UDPase

# Metabolic_Enzyme_9_Gene_Name:
ENTPD5

# Metabolic_Enzyme_9_Protein_Sequence:
>Ectonucleoside triphosphate diphosphohydrolase 5 precursor
MATSWGTVFFMLVVSCVCSAVSHRNQQTWFEGIFLSSMCPINVSASTLYGIMFDAGSTGT
RIHVYTFVQKMPGQLPILEGEVFDSVKPGLSAFVDQPKQGAETVQGLLEVAKDSIPRSHW
KKTPVVLKATAGLRLLPEHKAKALLFEVKEIFRKSPFLVPKGSVSIMDGSDEGILAWVTV
NFLTGQLHGHRQETVGTLDLGGASTQITFLPQFEKTLEQTPRGYLTSFEMFNSTYKLYTH
SYLGFGLKAARLATLGALETEGTDGHTFRSACLPRWLEAEWIFGGVKYQYGGNQEGEVGF
EPCYAEVLRVVRGKLHQPEEVQRGSFYAFSYYYDRAVDTDMIDYEKGGILKVEDFERKAR
EVCDNLENFTSGSPFLCMDLSYITALLKDGFGFADSTVLQLTKKVNNIETGWALGATFHL
LQSLGISH

# Metabolic_Enzyme_9_Number_of_Residues:
428

# Metabolic_Enzyme_9_Molecular_Weight:
47518

# Metabolic_Enzyme_9_Theoretical_pI:
6.29

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
Likely to promote reglycosylation reactions involved in glycoproteins folding and quality control in the endoplasmic reticulum. Hydrolyzes UDP, GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate

# Metabolic_Enzyme_9_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_9_Reaction:
A nucleoside diphosphate + H2O = a nucleotide + phosphate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF01150:GDA1_CD39

# Metabolic_Enzyme_9_Signals:
1-20

# Metabolic_Enzyme_9_Transmembrane_Regions:
29-51

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 3.6.1.6

# Metabolic_Enzyme_9_GenBank_ID_Protein:
3335102

# Metabolic_Enzyme_9_SwissProt_ID:
ENTP5_HUMAN (O75356)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
ENTPD5

# Metabolic_Enzyme_9_Geneatlas_id:
ENTPD5

# Metabolic_Enzyme_9_hgnc_id:
HGNC:3367

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum lumen

# Metabolic_Enzyme_9_Gene_Sequence:
>1287 bp
ATGGCCACTTCTTGGGGCACAGTCTTTTTCATGCTGGTGGTATCCTGTGTTTGCAGCGCT
GTCTCCCACAGGAACCAGCAGACTTGGTTTGAGGGTATCTTCCTGTCTTCCATGTGCCCC
ATCAATGTCAGCGCCAGCACCTTGTATGGAATTATGTTTGATGCAGGGAGCACTGGAACT
CGAATTCATGTTTACACCTTTGTGCAGAAAATGCCAGGACAGCTTCCAATTCTAGAAGGG
GAAGTTTTTGATTCTGTGAAGCCAGGACTTTCTGCTTTTGTAGATCAACCTAAGCAGGGT
GCTGAGACCGTTCAAGGGCTCTTAGAGGTGGCCAAAGACTCAATCCCCCGAAGTCACTGG
AAAAAGACCCCAGTGGTCCTAAAGGCAACAGCAGGACTACGCTTACTGCCAGAACACAAA
GCCAAGGCTCTGCTCTTTGAGGTAAAGGAGATCTTCAGGAAGTCACCTTTCCTGGTACCA
AAGGGCAGTGTTAGCATCATGGATGGATCCGACGAAGGCATATTAGCTTGGGTTACTGTG
AATTTTCTGACAGGTCAGCTGCATGGCCACAGACAGGAGACTGTGGGGACCTTGGACCTA
GGGGGAGCCTCCACCCAAATCACGTTCCTGCCCCAGTTTGAGAAAACTCTGGAACAAACT
CCTAGGGGCTACCTCACTTCCTTTGAGATGTTTAACAGCACTTATAAGCTCTATACACAT
AGTTACTTGGGATTTGGATTGAAAGCTGCAAGACTAGCAACCCTGGGAGCCCTGGAGACA
GAAGGGACTGATGGGCACACTTTCCGGAGTGCCTGTTTACCGAGATGGTTGGAAGCAGAG
TGGATCTTTGGGGGTGTGAAATACCAGTATGGTGGCAACCAAGAAGGGGAGGTGGGCTTT
GAGCCCTGCTATGCCGAAGTGCTGAGGGTGGTACGAGGAAAACTTCACCAGCCAGAGGAG
GTCCAGAGAGGTTCCTTCTATGCTTTCTCTTACTATTATGACCGAGCTGTTGACACAGAC
ATGATTGATTATGAAAAGGGGGGTATTTTAAAAGTTGAAGATTTTGAAAGAAAAGCCAGG
GAAGTGTGTGATAACTTGGAAAACTTCACCTCAGGCAGTCCTTTCCTGTGCATGGATCTC
AGCTACATCACAGCCCTGTTAAAGGATGGCTTTGGCTTTGCAGACAGCACAGTCTTACAG
CTCACAAAGAAAGTGAACAACATAGAGACGGGCTGGGCCTTGGGGGCCACCTTTCACCTG
TTGCAGTCTCTGGGCATCTCCCATTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AF039918

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_9_Locus:
14q24

# Metabolic_Enzyme_9_SNPs:
rs17094434; rs2074932; rs17094438; rs7145427; rs8019765; rs8015927; rs3742810; rs4903170; rs7157168; rs13743; rs10132807; rs11621118; rs8019320; rs10131935; rs4903167; rs12434581; rs7147063; rs11159052; rs8012398; rs3815331; rs1468505; rs9323594; rs11621114; rs11849883; rs10151810; rs2302117; rs8016802; rs11625830; rs7157723; rs11159054; rs17095091; rs11848840; rs8019882; rs8023037; rs11852193; rs11848515; rs17093884; rs4899488; rs11159056; rs11848920; rs7159179; rs9805994; rs11621860; rs12586508; rs8017421; rs34440436; rs4903169; rs8019173; rs4899486; rs11621948; rs2336742; rs2215134; rs2074933; rs2072292; rs11159051; rs4903163; rs7148202; rs758240; rs11623794; rs11623041; rs7157377; rs3742813; rs12432463; rs9323593; rs11621319; rs17782328; rs8009548; rs2074931; rs11844270; rs17094445; rs4903164; rs17094448; rs7152184; rs11625480; rs12433798; rs730505; rs17782351; rs3784042; rs12895057; rs17094410; rs3784041; rs12894825; rs12431489; rs4903165; rs3784040; rs8011908; rs3742812; rs17782334; rs17782344; rs8019021; rs4140924; rs11624946; rs3742815; rs7156320; rs2286416; rs7155210; rs7161037; rs6574156; rs34551399; rs35835514; rs9671223; rs10132605; rs8019192; rs34536315; rs11159055; rs1468504; rs36125609; rs7152100; rs28835061; rs2012788; rs10147158; rs12437297; rs35786140; rs35138656; rs35225003; rs4899489; rs10702518; rs12887906; rs10137581; rs35658632; rs10400727; rs34846091; rs12888014; rs28569465; rs4903171; rs2024098; rs4903166; rs12887863; rs35627737; rs11366353; rs8018226; rs11289010; rs28473715; rs12887762; rs11159053; rs34404213; rs12893501; rs34009014; rs10135303; rs34204939; rs35010174; rs12888039; rs34061808; rs12885276; rs12893760; rs12887706; rs12886808; rs12888854; rs36104161; rs17095096; rs35579176; rs35899271; rs7143207; rs12887368; rs8010533; rs11159057; rs35990462; rs34726924; rs11626725; rs35560902; rs10132736; rs35872561; rs1802182; rs10143201; rs12323875; rs12892802; rs12887745; rs12887823; rs12887718; rs34026159; rs28758488; rs33926682; rs9744017; rs12883479; rs34343369; rs35395399; rs34996002; rs34147949; rs35225829; rs7152860; rs2286413; rs3742811; rs11346481; rs34055220; rs11320515; rs4903162; rs12883870; rs12881091; rs11624284; rs36015948; rs41435451; rs28628660; rs8012388; rs8015274; rs34108477; rs3081896; rs34793473; rs10141634; rs7148332; rs35765182; rs9888592; rs34428282; rs34291455; rs7152760; rs35864336; rs9744018; rs36114216; rs7140260; rs33949642; rs33959730; rs1044591; rs34953001; rs11287731; rs12161877; rs10148057; rs10151933; rs1029704; rs1044640; rs10873263; rs11622390; rs11850995; rs2072291; rs2074930; rs2098029; rs3177205; rs3179800; rs3180447; rs3180945; rs3180946; rs34468446; rs34746680; rs3742816; rs3742817; rs3764859; rs3784039; rs4903168; rs7141392; rs740504; rs740505; rs8020310; rs8500

# Metabolic_Enzyme_9_General_References:
9676430

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5232

# Metabolic_Enzyme_10_Name:
Cytosolic 5'-nucleotidase 1B

# Metabolic_Enzyme_10_Synonyms:
Cytosolic 5'-nucleotidase IB; cN1B; cN-IB; Autoimmune infertility-related protein

# Metabolic_Enzyme_10_Gene_Name:
NT5C1B

# Metabolic_Enzyme_10_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
BMSQTSLKQKKNEPGMRSSKESLEAEKRKESDKTGVRLSNQMRRAVNPNHSLRCCPFQGH
SSCRRCLCAAEGTALGPCHTIRIYIHMCLLWEQGQQITMMRGSQESSLRKTDSRGYLVRS
QWSRISRSPSTKAPSIDEPRSRNTSAKLPSSSTSSRTPSTSPSLHDSSPPPLSGQPSLQP
PASPQLPRSLDSRPPTPPEPDPGSRRSTKMQENPEAWAQGIVREIRQTRDSQPLEYSRTS
PTEWKSSSQRRGIYPASTQLDRNSLSEQQQQQREDEDDYEAAYWASMRSFYEKNPSCSRP
WPPKPKNAITIALSSCALFNMVDGRKIYEQEGLEKYMEYQLTNENVILTPGPAFRFVKAL
QYVNARLRDLYPDEQDLFDIVLMTNNHAQVGVRLINSVNHYGLLIDRFCLTGGKDPIGYL
KAYLTNLYIAADSEKVQEAIQEGIASATMFDGAKDMAYCDTQLRVAFDGDAVLFSDESEH
FTKEHGLDKFFQYDTLCESKPLAQGPLKGFLEDLGRLQKKFYAKNERLLCPIRTYLVTAR
SAASSGARVLKTLRRWGLEIDEALFLAGAPKSPILVKIRPHIFFDDHMFHIEGAQRLGSI
AAYGFNKKFSS

# Metabolic_Enzyme_10_Number_of_Residues:
610

# Metabolic_Enzyme_10_Molecular_Weight:
68804

# Metabolic_Enzyme_10_Theoretical_pI:
9.03

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_10_General_Function:
Not Available

# Metabolic_Enzyme_10_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels

# Metabolic_Enzyme_10_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_10_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_10_GenBank_ID_Protein:
13774961

# Metabolic_Enzyme_10_SwissProt_ID:
5NT1B_HUMAN (Q96P26)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
NT5C1B

# Metabolic_Enzyme_10_Geneatlas_id:
NT5C1B

# Metabolic_Enzyme_10_hgnc_id:
HGNC:17818

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_10_Gene_Sequence:
>1699 bp
GGGCAAAAATGTGGATAACAACAAAAGAATTTCAACAGGTAAAAAAATGAGTCAAACATC
TCTCAAACAGAAAAAGAATGAGCCCGGAATGAGGTCCTCAAAAGAGAGTCTAGAAGCAGA
AAAAAGAAAGGAATCTGACAAAACAGGAGTTCGTCTGAGCAATCAGGGATCACAAGAATC
ATCACTGCGGAAGACAGACTCTCGAGGGTACCTTGTGCGCAGTCAATGGTCTAGAATATC
CCGGAGCCCATCCACCAAGGCTCCATCCATAGATGAGCCTAGAAGCAGGAACACCAGTGC
TAAGCTCCCCAGCAGCTCCACGAGCTCCCGGACTCCATCCACCTCCCCAAGCCTGCATGA
CTCCTCACCGCCGCCGCTGTCCGGGCAGCCCTCGCTCCAGCCACCCGCGTCGCCCCAGCT
GCCCCGGTCGCTGGACTCGCGGCCTCCCACGCCCCCAGAGCCCGATCCTGGCTCCCGGCG
CAGCACCAAAATGCAAGAAAATCCGGAGGCCTGGGCCCAAGGCATCGTGCGGGAAATCCG
CCAGACCCGGGACTCGCAGCCGCTGGAATATTCGCGCACGTCCCCCACCGAGTGGAAGTC
CTCCAGCCAGCGCAGGGGGATCTACCCCGCCTCCACCCAGCTGGACCGCAACTCTCTGTC
CGAGCAGCAGCAGCAGCAGCGGGAGGACGAAGACGACTACGAAGCTGCCTACTGGGCATC
CATGAAGTCGTTCTACGAAAAGAACCCGAGCTGCTGGCGCCCCTGGCCGCCCAAACCCAA
GAACGCCATCACCATTGCTCTCTCATCCTGCGCGCTCTTCAACATGGTGGACGGCAGGAA
AATCTACGAGCAAGAGGGTCTGGAAAAGTACATGGAGTATCAGCTCACCAATGAGAACGT
CATCCTGACCCCGGGCCCGGCGTTCCGTTTCGTCAAGGCACTACAGTATGTCAATGCTAG
ACTCCGTGATCTATATCCTGATGAACAGGACTTATTTGATATTGTACTGATGACTAATAA
CCATGCCCAAGTGGGAGTGCGGCTTATAAACAGCGTCAATCACTACGGCTTACTGATTGA
CCGCTTCTGTCTGACCGGGGGAAAAGACCCCATTGGCTATTTGAAGGCATATCTTACCAA
CTTGTATATTGCTGCAGATTCTGAAAAAGTGCAAGAGGCAATACAAGAAGGTATTGCCTC
TGCGACAATGTTTGATGGAGCCAAAGACATGGCTTACTGTGACACTCAGCTCCGTGTAGC
CTTTGATGGGGATGCTGTCCTCTTCTCTGATGAGTCTGAACATTTTACCAAGGAGCATGG
GCTGGACAAATTCTTCCAGTATGATACATTATGTGAAAGTAAGCCTCTTGCTCAGGGTCC
CCTAAAAGGCTTTCTGGAAGATTTAGGCAGACTGCAAAAGAAGTTCTATGCCAAAAATGA
ACGGTTACTTTGTCCTATCAGGACCTACCTGGTTACAGCTAGGAGTGCAGCCAGTTCAGG
CGCCCGTGTGCTGAAAACCTTCCGACGCTGGGGTCTAGAGATAGACGAAGCTCTTTTCCT
TGCTGGAGCCCCCAAAAGTCCCATCTTGGTGAAGATCCGGCCCCACATCTTCTTTGATGA
CCACATGTTCCACATTGAAGGGGCACAGAGGTTAGGTTCCATCGCAGCTTATGGCTTTAA
TAAAAAATTCAGTAGTTAG

# Metabolic_Enzyme_10_GenBank_ID_Gene:
AF356185

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_10_Locus:
2p24.2

# Metabolic_Enzyme_10_SNPs:
rs3902946; rs16985301; rs16985306; rs3747660; rs2346137; rs6720633; rs7594728; rs6531109; rs6710367; rs7557821; rs4832608; rs11893074; rs16985296; rs7561652; rs2317857; rs16985292; rs16985290; rs6741218; rs11096544; rs35590292; rs10183289; rs17752103; rs11885013; rs17701334; rs16985293; rs11903725; rs7604190; rs4832609; rs7592099; rs16985311; rs16985310; rs3810839; rs17852342; rs34254789; rs7594519; rs34129467; rs7605480; rs35165251; rs7603601; rs34836771; rs34186303; rs35711606; rs35729409; rs34953851; rs11291136; rs28474708; rs3046807; rs34660980; rs35519366; rs3046840; rs35419885; rs7557722; rs4300829; rs7592233; rs13020403; rs36121694; rs34127788; rs11889898; rs13403096; rs13411442; rs1373776; rs16985281; rs16985284; rs17751951; rs2346135; rs2346136; rs34722188; rs35805648; rs3810838; rs3910894

# Metabolic_Enzyme_10_General_References:
11690631

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
6162

# Metabolic_Enzyme_11_Name:
Adenylosuccinate synthetase isozyme 2

# Metabolic_Enzyme_11_Synonyms:
Adenylosuccinate synthetase, acidic isozyme; IMP--aspartate ligase 2; AdSS 2; AMPSase 2

# Metabolic_Enzyme_11_Gene_Name:
ADSS

# Metabolic_Enzyme_11_Protein_Sequence:
>Adenylosuccinate synthetase isozyme 2
MAFAETYPAASSLPNGDCGRPRARPGGNRVTVVLGAQWGDEGKGKVVDLLAQDADIVCRC
QGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGL
EGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLR
MCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYE
ALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAY
TTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALAL
TKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKE
LPVNAQNYVRFIEDELQIPVKWIGVGKSRESMIQLF

# Metabolic_Enzyme_11_Number_of_Residues:
456

# Metabolic_Enzyme_11_Molecular_Weight:
50098

# Metabolic_Enzyme_11_Theoretical_pI:
6.52

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  guanyl nucleotide binding
Function:  GTP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  adenylosuccinate synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
Plays an important role in the de novo pathway of purine nucleotide biosynthesis

# Metabolic_Enzyme_11_Pathway:
map00230  Purine metabolism;
 map00252  Alanine and aspartate metabolism

# Metabolic_Enzyme_11_Reaction:
GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00709:Adenylsucc_synt

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 6.3.4.4

# Metabolic_Enzyme_11_GenBank_ID_Protein:
415849

# Metabolic_Enzyme_11_SwissProt_ID:
PURA2_HUMAN (P30520)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
ADSS

# Metabolic_Enzyme_11_Geneatlas_id:
ADSS

# Metabolic_Enzyme_11_hgnc_id:
HGNC:292

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Cytoplasm. Note=Partially associated with particulate fractions

# Metabolic_Enzyme_11_Gene_Sequence:
>1368 bp
ATGGCGTTCGCCGAGACCTACCCGGCGGCATCCTCCCTGCCCAACGGCGATTGCGGCCGC
CCCAGGGCGGCCGGAGGAAACCGGGTGACGGTGGTGCTCGGTGCGCAGTGGGGCGACGAA
GGCAAAGGGAAGGTGGTGGACCTGCTGGCGCAGGACGCCGACATCGTGTGCCGCTGCCAG
GGAGGAAATAATGCTGGCCATACAGTTGTTGTGGATTCTGTGGAATATGATTTTCATCTC
TTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATT
CATCTACCTGGATTGTTTGAAGAAGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAA
GGCTGGGAAAAAAGGCTTATTATATCTGACAGAGCTCATATTGTATTTGATTTTCATCAA
GCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACA
ACAAAAAAGGGCATTGGCCCAGTTTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATG
TGCGACCTTGTTTCTGACTTTGATGGCTTCTCTGAGAGGTTTAAAGTTCTAGCTAACCAA
TACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAG
GGTTATATGGAAAAGATTAAACCAATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCC
CTACATGGACCACCAAAGAAAATCTTGGTAGAAGGTGCAAATGCAGCACTATTAGATATT
GATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACT
GGTTTGGGTATGCCACCTCAAAATGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACA
ACTAGAGTTGGTATTGGTGCCTTTCCTACAGAGCAAGACAATGAAATTGGAGAATTATTA
CAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTG
GACCTCGTTTTGCTCAAATATGCTCATATGATCAATGGATTTACTGCGTTGGCACTTACC
AAGTTGGATATTTTGGACATGTTTACGGAAATCAAAGTTGGAGTTGCTTACAAGTTAGAT
GGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAA
TATAAGACTCTCCCAGGATGGAACACAGACATATCAAATGCAAGGGCGTTTAAAGAACTA
CCTGTTAATGCACAAAACTATGTTCGATTTATTGAAGATGAGCTTCAAATTCCAGTTAAG
TGGATTGGTGTTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
X66503

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_11_Locus:
1cen-q12

# Metabolic_Enzyme_11_SNPs:
rs3087609; rs6702738; rs3003211; rs6661148; rs3127465; rs6686008; rs3006004; rs3101468; rs3101469; rs4132572; rs3127459; rs3102460; rs3123696; rs6695703; rs3127457; rs3003212; rs3003213; rs6429464; rs3127464; rs3127454; rs3123695; rs12408001; rs6679230; rs6699617; rs10927235; rs3127461; rs7521072; rs4658639; rs12087973; rs6684936; rs3123697; rs7545484; rs3127462; rs2306084; rs7539755; rs7545183; rs3006001; rs3127458; rs3127460; rs7539522; rs12569275; rs12410794; rs3127463; rs7527927; rs7517530; rs12047803; rs3102461; rs7551081; rs6677185; rs6685912; rs3124057; rs6666267; rs6669301; rs11801330; rs12042224; rs12041977; rs12408141; rs12045642; rs12087569; rs10927232; rs12145477; rs12402219; rs12032765; rs12116865; rs12071840; rs10927233; rs6685577; rs12563663; rs3127456; rs12080907; rs3124056; rs12128162; rs2068956; rs3006003; rs7518614; rs7540590; rs7518280; rs7518149; rs7529951; rs7532478; rs7530148; rs12134870; rs1131837; rs34994962; rs12085827; rs10653089; rs4306109; rs11434001; rs7525611; rs11355797; rs4132571; rs35783367; rs34529627; rs35132231; rs35033347; rs34327867; rs12024108; rs12023515; rs34764347; rs35232319; rs10593907; rs3127455; rs35495843; rs34487846; rs12026937; rs3003214; rs35199229; rs28429946; rs3006002; rs12734490; rs7546490; rs3214970; rs12408265; rs12027053; rs3003215; rs12754282; rs12724535; rs35190671; rs35133286; rs5782297; rs35946251; rs12021602; rs12129867; rs35213911; rs34630643; rs10652281; rs12754667; rs4658640; rs12097844; rs35147062; rs3127466; rs34361254; rs6667957; rs10692879; rs34075371; rs34914993; rs34710786; rs35629653; rs35944681; rs34063662; rs35548214; rs35275228; rs7540294; rs7518477; rs34801787; rs10927229; rs10927230; rs10927237; rs11579741; rs11580674; rs12084013; rs12136891; rs1237798; rs12404398; rs12404529; rs12730102; rs1601269; rs3006006; rs3102475; rs3124058; rs3127452; rs7524221; rs7524376

# Metabolic_Enzyme_11_General_References:
1592113

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5313

# Metabolic_Enzyme_12_Name:
Ectonucleoside triphosphate diphosphohydrolase 1

# Metabolic_Enzyme_12_Synonyms:
NTPDase 1; Ecto-ATP diphosphohydrolase; ATPDase; Lymphoid cell activation antigen; Ecto-apyrase; CD39 antigen

# Metabolic_Enzyme_12_Gene_Name:
ENTPD1

# Metabolic_Enzyme_12_Protein_Sequence:
>Ectonucleoside triphosphate diphosphohydrolase 1
MEDTKESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENVKYGIVLDAGSSHT
SLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQ
HQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWI
TINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFR
LYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTP
CTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAF
SAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYIL
SLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVFL
MVLFSLVLFTVAIIGLLIFHKPSYFWKDMV

# Metabolic_Enzyme_12_Number_of_Residues:
510

# Metabolic_Enzyme_12_Molecular_Weight:
57965

# Metabolic_Enzyme_12_Theoretical_pI:
6.29

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Not Available

# Metabolic_Enzyme_12_Specific_Function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation. Hydrolyzes ATP and ADP equally well

# Metabolic_Enzyme_12_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_12_Reaction:
ATP + 2 H2O = AMP + 2 phosphate

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF01150:GDA1_CD39

# Metabolic_Enzyme_12_Signals:
None

# Metabolic_Enzyme_12_Transmembrane_Regions:
17-37
479-499

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 3.6.1.5

# Metabolic_Enzyme_12_GenBank_ID_Protein:
765256

# Metabolic_Enzyme_12_SwissProt_ID:
ENTP1_HUMAN (P49961)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
ENTPD1

# Metabolic_Enzyme_12_Geneatlas_id:
ENTPD1

# Metabolic_Enzyme_12_hgnc_id:
HGNC:3363

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential)

# Metabolic_Enzyme_12_Gene_Sequence:
>1533 bp
ATGGAAGATACAAAGGAGTCTAACGTGAAGACATTTTGCTCCAAGAATATCCTAGCCATC
CTTGGCTTCTCCTCTATCATAGCTGTGATAGCTTTGCTTGCTGTGGGGTTGACCCAGAAC
AAAGCATTGCCAGAAAACGTTAAGTATGGGATTGTGCTGGATGCGGGTTCTTCTCACACA
AGTTTATACATCTATAAGTGGCCAGCAGAAAAGGAGAATGACACAGGCGTGGTGCATCAA
GTAGAAGAATGCAGGGTTAAAGGTCCTGGAATCTCAAAATTTGTTCAGAAAGTAAATGAA
ATAGGCATTTACCTGACTGATTGCATGGAAAGAGCTAGGGAAGTGATTCCAAGGTCCCAG
CACCAAGAGACACCCGTTTACCTGGGAGCCACGGCAGGCATGCGGTTGCTCAGGATGGAA
AGTGAAGAGTTGGCAGACAGGGTTCTGGATGTGGTGGAGAGGAGCCTCAGCAACTACCCC
TTTGACTTCCAGGGTGCCAGGATCATTACTGGCCAAGAGGAAGGTGCCTATGGCTGGATT
ACTATCAACTATCTGCTGGGCAAATTCAGTCAGAAAACAAGGTGGTTCAGCATAGTCCCA
TATGAAACCAATAATCAGGAAACCTTTGGAGCTTTGGACCTTGGGGGAGCCTCTACACAA
GTCACTTTTGTACCCCAAAACCAGACTATCGAGTCCCCAGATAATGCTCTGCAATTTCGC
CTCTATGGCAAGGACTACAATGTCTACACACATAGCTTCTTGTGCTATGGGAAGGATCAG
GCACTCTGGCAGAAACTGGCCAAGGACATTCAGGTTGCAAGTAATGAAATTCTCAGGGAC
CCATGCTTTCATCCTGGATATAAGAAGGTAGTGAACGTAAGTGACCTTTACAAGACCCCC
TGCACCAAGAGATTTGAGATGACTCTTCCATTCCAGCAGTTTGAAATCCAGGGTATTGGA
AACTATCAACAATGCCATCAAAGCATCCTGGAGCTCTTCAACACCAGTTACTGCCCTTAC
TCCCAGTGTGCCTTCAATGGGATTTTCTTGCCACCACTCCAGGGGGATTTTGGGGCATTT
TCAGCTTTTTACTTTGTGATGAAGTTTTTAAACTTGACATCAGAGAAAGTCTCTCAGGAA
AAGGTGACTGAGATGATGAAAAAGTTCTGTGCTCAGCCTTGGGAGGAGATAAAAACATCT
TACGCTGGAGTAAAGGAGAAGTACCTGAGTGAATACTGCTTTTCTGGTACCTACATTCTC
TCCCTCCTTCTGCAAGGCTATCATTTCACAGCTGATTCCTGGGAGCACATCCATTTCATT
GGCAAGATCCAGGGCAGCGACGCCGGCTGGACTTTGGGCTACATGCTGAACCTGACCAAC
ATGATCCCAGCTGAGCAACCATTGTCCACACCTCTCTCCCACTCCACCTATGTCTTCCTC
ATGGTTCTATTCTCCCTGGTCCTTTTCACAGTGGCCATCATAGGCTTGCTTATCTTTCAC
AAGCCTTCATATTTCTGGAAAGATATGGTATAG

# Metabolic_Enzyme_12_GenBank_ID_Gene:
S73813

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_12_Locus:
10q24

# Metabolic_Enzyme_12_SNPs:
rs3793744; rs3181132; rs1342790; rs3176883; rs3181124; rs1573112; rs3176891; rs2153913; rs3176890; rs10748643; rs7077566; rs4431963; rs6584033; rs4582902; rs10882665; rs6584026; rs2185818; rs10748649; rs4075310; rs3176881; rs5014871; rs7097489; rs7919196; rs4481960; rs4918968; rs10882664; rs1891534; rs7096610; rs10509686; rs7083960; rs4322324; rs3892344; rs3181123; rs4396219; rs4512761; rs4917715; rs7921242; rs7074403; rs1891536; rs4244321; rs2861152; rs1418709; rs3181131; rs2275759; rs4075311; rs10882671; rs4917714; rs1340837; rs6584027; rs3176885; rs7088952; rs12262943; rs11598475; rs4320886; rs17111156; rs11188486; rs10882676; rs7096248; rs3929900; rs4918969; rs4551688; rs7093453; rs3897983; rs2901874; rs10882673; rs4918971; rs2901873; rs2861153; rs6584031; rs10736092; rs7893677; rs3181129; rs4917707; rs11188497; rs7088961; rs7902190; rs10882660; rs2105359; rs6584028; rs7901116; rs7913082; rs10736093; rs3176884; rs7900927; rs4614366; rs10786236; rs2901872; rs7067762; rs11188485; rs7089668; rs4409759; rs7070507; rs11595122; rs10882670; rs10786235; rs1539433; rs7100137; rs7088584; rs11818540; rs10748648; rs4336964; rs10882675; rs1342791; rs4074424; rs4918970; rs3181122; rs12767650; rs3901451; rs11816167; rs11188475; rs3181121; rs7915345; rs3176887; rs2861151; rs6584030; rs4412693; rs11594340; rs7921000; rs7894940; rs3176882; rs7898379; rs11188496; rs3181118; rs3176886; rs10882661; rs10882666; rs7901386; rs2275760; rs7090320; rs12770849; rs3181125; rs7915682; rs3901450; rs11188501; rs10786237; rs7900546; rs10748644; rs10786234; rs7915087; rs7913018; rs7894676; rs7914736; rs1935816; rs1418710; rs10748645; rs10786233; rs7069234; rs4406763; rs10882662; rs11188502; rs7915308; rs3176889; rs7095489; rs11593761; rs7082531; rs7914286; rs2861154; rs7083411; rs3176888; rs10882663; rs7920372; rs10748647; rs12780375; rs12354848; rs7476775; rs11188484; rs11188495; rs12763743; rs10882668; rs4272738; rs11188488; rs7900841; rs7921302; rs11188492; rs10786238; rs12244606; rs7915499; rs10882669; rs11188498; rs7904990; rs11592584; rs12770313; rs10882674; rs11188504; rs3181127; rs7915380; rs3176894; rs3814159; rs3176893; rs3176895; rs3176892; rs1804825; rs12240959; rs4463786; rs34293555; rs34399092; rs35135296; rs11389794; rs3980180; rs10736091; rs11407296; rs11188487; rs11597953; rs11188493; rs5787157; rs4472866; rs4539246; rs34736818; rs34473397; rs35488296; rs35597960; rs4420188; rs35620983; rs5787162; rs9663685; rs35826614; rs7900437; rs34166835; rs10585205; rs11188508; rs34177114; rs36017526; rs3181128; rs10672739; rs4581382; rs5787158; rs12354620; rs12265109; rs11188494; rs11188482; rs4433506; rs34836127; rs34248770; rs35444953; rs35537802; rs3980181; rs34907927; rs35452058; rs34858625; rs7896855; rs35809029; rs11517041; rs11188479; rs35615283; rs34279173; rs12360382; rs34421483; rs34720050; rs34980662; rs35782220; rs11574649; rs11393527; rs7909739; rs7088411; rs12572063; rs34872816; rs12258207; rs5787161; rs11188481; rs11188511; rs28542865; rs35164560; rs4917705; rs7900229; rs11527887; rs35203111; rs3897464; rs34082135; rs34627984; rs35360884; rs11188509; rs34308669; rs35650706; rs11188506; rs4325249; rs35298724; rs35859772; rs11188510; rs5787159; rs1418711; rs11574648; rs34367283; rs34925455; rs34296389; rs11188480; rs11528098; rs34873600; rs7898964; rs34863917; rs11188489; rs34997042; rs3961946; rs35748815; rs35177231; rs12357414; rs11188490; rs12355114; rs34077465; rs35535706; rs35825117; rs35417010; rs9702308; rs4481957; rs35854596; rs11188505; rs7911911; rs5787163; rs34850860; rs12782273; rs11188477; rs11188491; rs12774334; rs3897465; rs11188473; rs9664384; rs11188503; rs33998152; rs11188483; rs4402217; rs35861909; rs35700869; rs3961947; rs35516259; rs11498722; rs5787160; rs34143181; rs10736094; rs11188466; rs11188469; rs11188471; rs11188512; rs11188513; rs11188514; rs12358481; rs12761960; rs12775598; rs12781189; rs17462179; rs17553401; rs1935815; rs2051052; rs2096218; rs2153914; rs2226163; rs3181114; rs3181115; rs3181116; rs3192654; rs34630379; rs34793678; rs4918966; rs6584022; rs6584023; rs7086986; rs7090630; rs7096317; rs7098750; rs7100644; rs7923971

# Metabolic_Enzyme_12_General_References:
7930580; 8996251; 10405171; 8529670; 9846014; 8955160; 8626624; 10636909

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5871

# Metabolic_Enzyme_13_Name:
AMP deaminase 2

# Metabolic_Enzyme_13_Synonyms:
AMP deaminase isoform L

# Metabolic_Enzyme_13_Gene_Name:
AMPD2

# Metabolic_Enzyme_13_Protein_Sequence:
>AMP deaminase 2
MRNRGQGLFRLRSRCFLHQSLPLGAGRRKGLDVAEPGPSRCRSDSPAVAAVVPAMASYPS
GSGKPKAKYPFKKRASLQASTAAPEARGGLGAPPLQSARSLPGPAPCLKHFPLDLRTSMD
GKCKEIAEELFTRSLAESELRSAPYEFPEESPIEQLEERRQRLERQISQDVKLEPDILLR
AKQDFLKTDSDSDLQLYKEQGEGQGDRSLRERDVLEREFQRVTISGEEKCGVPFTDLLDA
AKSVVRALFIREKYMALSLQSFCPTTRRYLQQLAEKPLETRTYEQGPDTPVSADAPVHPP
ALEQHPYEHCEPSTMPGDLGLGLRMVRGVVHVYTRREPDEHCSEVELPYPDLQEFVADVN
VLMALIINGPIKSFCYRRLQYLSSKFQMHVLLNEMKELAAQKKVPHRDFYNIRKVDTHIH
ASSCMNQKHLLRFIKRAMKRHLEEIVHVEQGREQTLREVFESMNLTAYDLSVDTLDVHAD
RNTFHRFDKFNAKYNPIGESVLREIFIKTDNRVSGKYFAHIIKEVMSDLEESKYQNAELR
LSIYGRSRDEWDKLARWAVMHRVHSPNVRWLVQVPRLFDVYRTKGQLANFQEMLENIFLP
LFEATVHPASHPELHLFLEHVDGFDSVDDESKPENHVFNLESPLPEAWVEEDNPPYAYYL
YYTFANMAMLNHLRRQRGFHTFVLRPHCGEAGPIHHLVSAFMLAENISHGLLLRKAPVLQ
YLYYLAQIGIAMSPLSNNSLFLSYHRNPLPEYLSRGLMVSLSTDDPLQFHFTKEPLMEEY
SIATQVWKLSSCDMCELARNSVLMSGFSHKVKSHWLGPNYTKEGPEGNDIRRTNVPDIRV
GYRYETLCQELALITQAVQSEMLETIPEEAGITMSPGPQ

# Metabolic_Enzyme_13_Number_of_Residues:
879

# Metabolic_Enzyme_13_Molecular_Weight:
100689

# Metabolic_Enzyme_13_Theoretical_pI:
6.93

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  AMP deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Not Available

# Metabolic_Enzyme_13_Specific_Function:
AMP deaminase plays a critical role in energy metabolism

# Metabolic_Enzyme_13_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_13_Reaction:
AMP + H2O = IMP + ammonia

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
None

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 3.5.4.6

# Metabolic_Enzyme_13_GenBank_ID_Protein:
644509

# Metabolic_Enzyme_13_SwissProt_ID:
AMPD2_HUMAN (Q01433)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
AMPD2

# Metabolic_Enzyme_13_Geneatlas_id:
AMPD2

# Metabolic_Enzyme_13_hgnc_id:
HGNC:469

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_13_Gene_Sequence:
>2263 bp
CGCCGAGGAGCTGTTCACCCGCTCACTGGCTGAGAGCGAGCTCCGTAGTGCCCCGTATGA
GTTCCCCGAGGAGAGCCCCATTGAACAGCTGGAGGAGCGGCGGCAGCGGCTGGAGCGGCA
GATCAGCCAGGATGTCAAGCTGGAGCCAGACATCCTGCTTCGGGCCAAGCAAGATTTCCT
GAAGACGGACAGTGACTCGGACCTACAGCTCTACAAGGAACAGGGTGAGGGGCAGGGTGA
CCGGAGCCTGCGGGAGCGTGATGTGCTGGAACGGGAGTTTCAGCGGGTCACCATCTCTGG
GGAGGAGAAGTGTGGGGTGCCGTTCACAGACCTGCTGGATGCAGCCAAGAGTGTGGTGCG
GGCGCTCTTCATCCGGGAGAAGTACATGGCCCTGTCCCTGCAGAGCTTCTGCCCCACCAC
CCGCCGCTACCTGCAGCAGCTGGCTGAAAAGCCTCTGGAGACCCGGACCTATGAACAGGG
CCCCGACACCCCTGTGTCTGCTGATGCCCCGGTGCACCCCCCTGCGCTGGAGCAGCACCC
GTATGAGCACTGTGAGCCAAGCACCATGCCTGGGGACCTGGGCTTGGGTCTGCGCATGGT
GCGGGGTGTGGTGCACGTCTACACCCGCAGGGAACCCGACGAGCATTGCTCAGAGGTGGA
GCTGCCATACCCTGACCTGCAGGAATTTGTGGCTGACGTCAATGTGCTGATGGCCCTGAT
TATCAATGGCCCCATAAAGTCATTCTGCTACCGCCGGCTGCAGTACCTGAGCTCCAAGTT
CCAGATGCATGTGCTACTCAATGAGATGAAGGAGCTGGCCGCCCAGAAGAAAGTGCCACA
CCGAGATTTCTACAACATCCGCAAGGTGGACACCCACATCCATGCCTCGTCCTGCATGAA
CCAGAAGCATCTGCTGCGCTTCATCAAGCGGGCAATGAAGCGGCACCTGGAGGAGATCGT
GCACGTGGAGCAGGGCCGTGAACAGACGCTGCGGGAGGTCTTTGAGAGCATGAATCTCAC
GGCCTACGACCTGAGTGTGGACACGCTGGATGTGCATGCGGACAGGAACACTTTCCATCG
CTTTGACAAGTTTAATGCCAAATACAACCCTATTGGGGAGTCCGTCCTCCGAGAGATCTT
CATCAAGACGGACAACAGGGTATCTGGGAAGTACTTTGCTCACATCATCAAGGAGGTGAT
GTCAGACCTGGAGGAGAGCAAATACCAGAATGCAGAGCTGCGGCTCTCCATTTACGGGCG
CTCGAGGGATGAGTGGGACAAGCTGGCGCGCTGGGCCGTCATGCACCGCGTGCACTCCCC
CAACGTGCGCTGGCTGGTGCAGGTGCCCCGCCTCTTTGATGTGTACCGTACCAAGGGCCA
GCTGGCCAACTTCCAGGAGATGCTGGAGAACATCTTCCTGCCACTGTTCGAGGCCACTGT
GCACCCTGCCAGCCACCCGGAACTGCATCTCTTCTTAGAGCACGTGGATGGTTTTGACAG
CGTGGATGATGAGTCCAAGCCTGAAAACCATGTCTTCAACCTGGAGAGCCCCCTGCCTGA
GGCGTGGGTGGAGGAGGACAACCCACCCTATGCCTACTACCTGTACTACACCTTTGCCAA
CATGGCCATGTTGAACCACCTGCGCAGGCAGAGGGGCTTCCACACGTTTGTGCTGAGGCC
ACACTGTGGGGAGGCTGGGCCCATCCACCACCTGGTGTCAGCCTTCATGCTGGCTGAGAA
CATTTCCCACGGGCTCCTTCTGCGCAAGGCCCCCGTCCTGCAGTACCTGTACTACCTGGC
CCAGATCGGCATCGCCATGTCTCCGCTCAGCAACAACAGCCTCTTCCTCAGCTATCACCG
GAATCCGCTACCGGAGTACCTGTCCCGCGGCCTCATGGTCTCCCTGTCCACTGATGATCC
CTTGCAGTTCCACTTCACCAAGGAGCCGCTGATGGAGGAGTACAGCATCGCCACCCAGGT
GTGGAAGCTCAGCTCCTGCGATATGTGTGAGCTGGCCCGCAACAGCGTGCTCATGAGCGG
CTTCTCGCACAAGGTAAAGAGCCACTGGCTGGGACCCAACTATACCAAGGAAGGCCCTGA
GGGGAATGACATCCGCCGGACCAATGTGCCAGACATCCGCGTGGGCTACCGCTACGAGAC
CCTGTGCCAGGAGCTGGCGCTCATCACGCAGGCAGTCCAGAGTGAGATGCTGGAGACCAT
TCCAGAGGAGGCGGGTATCACCATGAGCCCAGGGCCTCAATGA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
M91029

# Metabolic_Enzyme_13_Chromosome_Location:
Not Available

# Metabolic_Enzyme_13_Locus:
Not Available

# Metabolic_Enzyme_13_SNPs:
Not Available

# Metabolic_Enzyme_13_General_References:
1429593; 8526848; 8764830

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
6163

# Metabolic_Enzyme_14_Name:
Inosine-5'-monophosphate dehydrogenase 2

# Metabolic_Enzyme_14_Synonyms:
IMP dehydrogenase 2; IMPDH-II; IMPD 2

# Metabolic_Enzyme_14_Gene_Name:
IMPDH2

# Metabolic_Enzyme_14_Protein_Sequence:
>Inosine5'monophosphate dehydrogenase 2
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPM
DTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPV
VLSPKDRVRDVFEAKARHGFC
GIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEI
MTKREDLVVAPAGITLKEANEILQRSKKGKLP
IVNEDDELVAIIARTDLKKNRDYPLAS
KDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNS
IFQINMIKYIKDKYPN
LQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKV
SEYAR
RFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMG
SLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAK
SLTQVRAMMYSGELKF
EKRTSSAQVEGGVHSLHSYEKRLF

# Metabolic_Enzyme_14_Number_of_Residues:
514

# Metabolic_Enzyme_14_Molecular_Weight:
55806

# Metabolic_Enzyme_14_Theoretical_pI:
6.90

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  IMP dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
Process:  GMP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors

# Metabolic_Enzyme_14_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_14_Reaction:
inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00571:CBS;
PF00478:IMPDH

# Metabolic_Enzyme_14_Signals:
None

# Metabolic_Enzyme_14_Transmembrane_Regions:
None

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 1.1.1.205

# Metabolic_Enzyme_14_GenBank_ID_Protein:
307066

# Metabolic_Enzyme_14_SwissProt_ID:
IMDH2_HUMAN (P12268)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
IMPDH2

# Metabolic_Enzyme_14_Geneatlas_id:
IMPDH2

# Metabolic_Enzyme_14_hgnc_id:
HGNC:6053

# Metabolic_Enzyme_14_PDB_ID:
1NFB

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Not Available

# Metabolic_Enzyme_14_Gene_Sequence:
>1545 bp

ATGGCCGACTACCTGATTAGTGGGGGCACGTCCTACGTGCCAGACGACGGACTCACAGC
ACAGCAGCTCT
TCAACTGCGGAGACGGCCTCACCTACAATGACTTTCTCATTCTCCCTG
GGTACATCGACTTCACTGCAGA
CCAGGTGGACCTGACTTCTGCTCTGACCAAGAAAATC
ACTCTTAAGACCCCACTGGTTTCCTCTCCCATG
GACACAGTCACAGAGGCTGGGATGGC
CATAGCAATGGCGCTTACAGGCGGTATTGGCTTCATCCACCACA
ACTGTACACCTGAAT
TCCAGGCCAATGAAGTTCGGAAAGTGAAGAAATATGAACAGGGATTCATCACAGA
CCCT
GTGGTCCTCAGCCCCAAGGATCGCGTGCGGGATGTTTTTGAGGCCAAGGCCCGGCATGGT
TTCTGC
GGTATCCCAATCACAGACACAGGCCGGATGGGGAGCCGCTTGGTGGGCATCAT
CTCCTCCAGGGACATTG
ATTTTCTCAAAGAGGAGGAACATGACTGTTTCTTGGAAGAGA
TAATGACAAAGAGGGAAGACTTGGTGGT
AGCCCCCCGCAGCATCACACTGAAGGAGGCA
AATGAAATTCTGCAGCGCAGCAAGAAGGGAAAGTTGCCC
ATTGTAAATGAAGATGATGA
GCTTGTGGCCATCATTGCCCGGACAGACCTGAAGAAGAATCGGGACTACC
CACTAGCCT
CCAAAGATGCCAAGAAACAGCTGCTGTGTGGGGCAGCCATTGGCACTCATGAGGATGACA
A
GTATAGGCTGGACTTGCTCGCCCAGGCTGGTGTGGATGTAGTGGTTTTGGACTCTTCC
CAGGGAAATTCC
ATCTTCCAGATCAATATGATCAAGTACATCAAAGACAAATACCCTAA
TCTCCAAGTCATTGGAGGCAATG
TGGTCACTGCTGCCCAGGCCAAGAACCTCATTGATG
CAGGTGTGGATGCCCTGCGGGTGGGCATGGGAAG
TGGCTCCATCTGCATTACGCAGGAA
GTGCTGGCCTGTGGGCGGCCCCAAGCAACAGCAGTGTACAAGGTG
TCAGAGTATGCACG
GCGCTTTGGTGTTCCGGTCATTGCTGATGGAGGAATCCAAAATGTGGGTCATATTG
CGA
AAGCCTTGGCCCTTGGGGCCTCCACAGTCATGATGGGCTCTCTCCTGGCTGCCACCACTG
AGGCCCC
TGGTGAATACTTCTTTTCCGATGGGATCCGGCTAAAGAAATATCGCGGTATG
GGTTCTCTCGATGCCATG
GACAAGCACCTCAGCAGCCAGAACAGATATTTCAGTGAAGC
TGACAAAATCAAAGTGGCCCAGGGAGTGT
CTGGTGCTGTGCAGGACAAAGGGTCAATCC
ACAAATTTGTCCCTTACCTGATTGCTGGCATCCAACACTC
ATGCCAGGACATTGGTGCC
AAGAGCTTGACCCAAGTCCGAGCCATGATGTACTCTGGGGAGCTTAAGTTT
GAGAAGAG
AACGTCCTCAGCCCAGGTGGAAGGTGGCGTCCATAGCCTCCATTCGTATGAGAAGCGGCT
TT
TCTGA

# Metabolic_Enzyme_14_GenBank_ID_Gene:
J04208

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_14_Locus:
3p21.2

# Metabolic_Enzyme_14_SNPs:
rs11706052; rs11557540; rs1049818; rs11557544; rs11557543; rs11557546; rs11557547; rs11557542; rs35568560; rs3929973; rs3929975; rs3929974; rs35855647; rs34556154; rs3891188; rs1134122; rs3891187; rs11706445; rs12634316; rs13083145; rs3087866; rs3923475; rs3923476; rs4974081; rs7100; rs8926

# Metabolic_Enzyme_14_General_References:
2902093; 1969416; 7999076; 7896827; 8098009; 7763314; 10097070

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5715

# Metabolic_Enzyme_15_Name:
Hypoxanthine-guanine phosphoribosyltransferase

# Metabolic_Enzyme_15_Synonyms:
HGPRT; HGPRTase

# Metabolic_Enzyme_15_Gene_Name:
HPRT1

# Metabolic_Enzyme_15_Protein_Sequence:
>Hypoxanthineguanine phosphoribosyltransferase
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA

# Metabolic_Enzyme_15_Number_of_Residues:
218

# Metabolic_Enzyme_15_Molecular_Weight:
24580

# Metabolic_Enzyme_15_Theoretical_pI:
6.67

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
Function:  hypoxanthine phosphoribosyltransferase activity
 ||
>>>
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  purine salvage
Process:  purine ribonucleoside salvage
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_15_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_15_Specific_Function:
IMP + diphosphate = hypoxanthine + 5-phospho- alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_15_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_15_Reaction:
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00156:Pribosyltran

# Metabolic_Enzyme_15_Signals:
None

# Metabolic_Enzyme_15_Transmembrane_Regions:
None

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 2.4.2.8

# Metabolic_Enzyme_15_GenBank_ID_Protein:
306885

# Metabolic_Enzyme_15_SwissProt_ID:
HPRT_HUMAN (P00492)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
HPRT1

# Metabolic_Enzyme_15_Geneatlas_id:
HPRT1

# Metabolic_Enzyme_15_hgnc_id:
HGNC:5157

# Metabolic_Enzyme_15_PDB_ID:
1BZY

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_15_Gene_Sequence:
>657 bp
ATGGCGACCCGCAGCCCTGGCGTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGAT
TTATTTTGCATACCTAATCATTATGCTGAGGATTTGGAAAGGGTGTTTATTCCTCATGGA
CTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCAT
CACATTGTAGCCCTCTGTGTGCTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGAT
TACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACTGTAGATTTTATC
AGACTGAAGAGCTATTGTAATGACCAGTCAACAGGGGACATAAAAGTAATTGGTGGAGAT
GATCTCTCAACTTTAACTGGAAAGAATGTCTTGATTGTGGAAGATATAATTGACACTGGC
AAAACAATGCAGACTTTGCTTTCCTTGGTCAGGCAGTATAATCCAAAGATGGTCAAGGTC
GCAAGCTTGCTGGTGAAAAGGACCCCACGAAGTGTTGGATATAAGCCAGACTTTGTTGGA
TTTGAAATTCCAGACAAGTTTGTTGTAGGATATGCCCTTGACTATAATGAATACTTCAGG
GATTTGAATCATGTTTGTGTCATTAGTGAAACTGGAAAAGCAAAATACAAAGCCTAA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
M31642

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_15_Locus:
Xq26.1

# Metabolic_Enzyme_15_SNPs:
rs17882614; rs17324664; rs1468266; rs6638240; rs6638244; rs629; rs12687175; rs2070888; rs17882706; rs17879768; rs6638243; rs6634993; rs2283774; rs2515695; rs17324671; rs17000619; rs17879343; rs17881098; rs17883992; rs17882148; rs6634992; rs17885981; rs17879832; rs17879883; rs17882974; rs17879054; rs6654281; rs17885745; rs17878776; rs17885116; rs17882408; rs17883944; rs17879655; rs17879788; rs17885487; rs17879062; rs12383909; rs17882655; rs6638248; rs17879889; rs6638241; rs17880246; rs17879587; rs12008402; rs17885587; rs17879537; rs17885351; rs17879338; rs17886003; rs17884897; rs17879126; rs17884671; rs17878519; rs17885249; rs17878726; rs17882575; rs630; rs17879579; rs17885481; rs17882577; rs17882724; rs17880173; rs17882449; rs17878366; rs17883719; rs17882059; rs17885063; rs17878341; rs17885117; rs17882713; rs17882954; rs17878494; rs17882387; rs17879006; rs17886404; rs17879389; rs17885867; rs17883942; rs17878843; rs17885455; rs17882760; rs17884775; rs6634990; rs6634995; rs17878582; rs17878883; rs17882358; rs17879110; rs17881011; rs35095771; rs41299094; rs17879494; rs17878772; rs11369747; rs12839009; rs17880167; rs17882944; rs17881023; rs374290; rs35009311; rs17883755; rs12861067; rs17882363; rs34425749; rs34838035; rs366687; rs6638242; rs17879610; rs28478865; rs17887208; rs405630; rs12380958; rs5903878; rs17878547; rs35869442; rs387714; rs35585686; rs6634994; rs17882487; rs17879085; rs5978009; rs5933415; rs17883196; rs116493; rs5933416; rs12836923; rs12381664; rs35238558; rs17882186; rs373901; rs35653185; rs17881003; rs6638245; rs35325865; rs35834777; rs11406107; rs17884978; rs17885259; rs17882884; rs17883708; rs12836918; rs391918; rs34619253; rs377106; rs35538011; rs17884910; rs398712; rs5933414; rs35832135; rs17885490; rs12381784; rs377103; rs5903877; rs17880051; rs12838998; rs17878536; rs11344152; rs2503983; rs36109224; rs17884854; rs17878792; rs17878589; rs7472760; rs28663133; rs117407; rs17881034; rs12381662; rs17886030; rs6638246; rs17885101; rs17879848; rs17879532; rs17882283; rs417522; rs17878403; rs414365; rs5978007; rs398716; rs7357883; rs10482430; rs12689866; rs12847109; rs437849; rs4829768; rs6634997; rs6638238

# Metabolic_Enzyme_15_General_References:
6300847; 2341149; 7107641; 3023844; 8044844; 10360366; 10338013; 1487231; 6853490; 6853716; 6572373; 6706936; 3358423; 3384338; 3265398; 2896620; 3198771; 3148064; 2572141; 2909537; 2910902; 2738157; 2928313; 2347587; 2358296; 2246854; 2018042; 2071157; 1937471; 1840476; 1551676; 1301916; 7627191; 9003484; 9452051

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5610

# Metabolic_Enzyme_16_Name:
Glycogen phosphorylase, muscle form

# Metabolic_Enzyme_16_Synonyms:
Myophosphorylase

# Metabolic_Enzyme_16_Gene_Name:
PYGM

# Metabolic_Enzyme_16_Protein_Sequence:
>Glycogen phosphorylase, muscle form
MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTV
RDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDM
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEA
DDWLRYGNPWEKARPEFTLPVHFYGHVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVN
TMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERM
DWDKAWDVTVRTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFP
GDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKF
QNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLDQLRKLLSFVDDEAFIRDVAKVKQ
ENKLKFAAYLEREYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKREPNKFFV
PRTVMIGGKAAPGYHMAKMIIRLVTAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPA
ADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVD
KLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYED
YIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE
AI

# Metabolic_Enzyme_16_Number_of_Residues:
842

# Metabolic_Enzyme_16_Molecular_Weight:
97093

# Metabolic_Enzyme_16_Theoretical_pI:
7.03

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
Function:  phosphorylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_16_Specific_Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

# Metabolic_Enzyme_16_Pathway:
map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_16_Reaction:
(1,4-alpha-D-glucosyl)n + phosphate = (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF00343:Phosphorylase

# Metabolic_Enzyme_16_Signals:
None

# Metabolic_Enzyme_16_Transmembrane_Regions:
None

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 2.4.1.1

# Metabolic_Enzyme_16_GenBank_ID_Protein:
190784

# Metabolic_Enzyme_16_SwissProt_ID:
PYGM_HUMAN (P11217)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
PYGM

# Metabolic_Enzyme_16_Geneatlas_id:
PYGM

# Metabolic_Enzyme_16_hgnc_id:
HGNC:9726

# Metabolic_Enzyme_16_PDB_ID:
1XL1

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Not Available

# Metabolic_Enzyme_16_Gene_Sequence:
>2529 bp
ATGTCCCGGCCCCTGTCAGACCAAGAGAAAAGAAAGCAAATCAGTGTGCGTGGCCTGGCC
GGCGTGGAGAACGTGACTGAGCTGAAAAAGAACTTCAACCGGCACCTGCATTTCACACTC
GTAAAGGACCGCAATGTGGCCACCCCACGAGACTACTACTTTGCTCTGGCCCATACCGTG
CGCGACCACCTCGTGGGGCGGTGGATCCGCACGCAGCAGCACTACTATGAGAAGGACCCC
AAGAGGATCTACTACCTGTCTTTAGAGTTCTATATGGGACGGACGCTACAGAACACCATG
GTGAACCTGGCCTTAGAGAATGCCTGTGACGAGGCCACCTACCAGCTGGGCCTGGACATG
GAGGAGCTGGAGGAAATTGAGGAGGATGCGGGGCTGGGCAACGGGGGCCTGGGCCGGCTG
GCAGCCTGCTTTCTTGACTCCATGGCAACACTGGGCCTGGCTGCCTATGGCTACGGGATT
CGCTATGAGTTTGGGATTTTTAACCAGAAGATCTCCGGGGGCTGGCAGATGGAGGAGGCC
GATGACTGGCTTCGCTACGGCAACCCCTGGGAGAAGGCCCGGCCCGAGTTCACGCTACCT
GTGCACTTCTACGGCCATGTGGAGCACACCAGCCAGGGTGCCAAGTGGGTGGACACACAG
GTGGTACTGGCCATGCCCTACGATACCCCGGTGCCTGGCTATCGCAACAATGTTGTCAAC
ACCATGCGCCTCTGGTCTGCCAAGGCTCCCAATGACTTCAACCTCAAGGACTTCAATGTC
GGTGGCTACATCCAGGCTGTGTTGGACCGAAACCTGGCGGAGAACATCTCTCGTGTCCTG
TACCCCAATGATAATTTCTTCGAAGGGAAGGAGCTGCGGCTGAAGCAGGAGTATTTCGTG
GTGGCTGCCACCCTCCAGGACATCATCCGTCGCTTCAAGTCTTCCAAGTTCGGCTGCCGT
GATCCCGTGCGCACGAACTTCGATGCCTTCCCAGATAAGGTGGCCATCCAGCTCAATGAC
ACCCACCCCTCCCTGGCCATCCCCGAGCTGATGAGGATCCTGGTGGACCTGGAACGGATG
GACTGGGACAAGGCGTGGGATGTGACAGTGAGGACCTGTGCCTACACCAACCACACGGTG
CTGCCCGAGGCCCTGGAGCGCTGGCCGGTGCACCTCTTGGAGACGCTGCTGCCGCGGCAC
CTCCAGATCATCTACGAGATCAACCAGCGCTTCCTCAACCGGGTGGCGGCCGCATTCCCA
GGGGACGTAGACCGGCTGCGGCGCATGTCGCTGGTGGAGGAGGGCGCAGTGAAGCGCATC
AACATGGCACACCTGTGCATCGCGGGGTCGCACGCCGTCAACGGTGTGGCCCGCATCCAC
TCGGAGATCCTCAAGAAGACCATCTTCAAAGACTTCTATGAGCTGGAGCCTCATAAGTTC
CAGAATAAGACCAACGGCATCACCCCTCGGCGCTGGCTGGTTCTGTGTAACCCCGGGCTG
GCAGAGGTCATTGCTGAGCGCATCGGGGAGGACTTCATCTCTGACCTGGACCAGCTGCGC
AAACTGCTCTCCTTTGTGGATGATGAAGCTTTCATTCGGGATGTGGCCAAAGTGAAGCAG
GAAAACAAGTTGAAGTTTGCTGCCTACCTAGAGAGGGAATACAAAGTCCACATCAACCCC
AACTCACTCTTCGACATCCAGGTGAAGCGGATTCACGAATATAAACGACAGCTCCTCAAC
TGCCTCCATGTCATCACCCTGTACAACCGCATCAAGAGGGAGCCCAATAAGTTTTTTGTG
CCTCGGACTGTGATGATTGGAGGGAAGGCTGCACCTGGGTACCACATGGCCAAGATGATC
ATCAGACTCGTCACAGCCATCGGGGATGTGGTCAACCATGACCCGGCAGTGGGTGACCGC
CTCCGTGTCATCTTCCTGGAGAACTACCGAGTCTCACTGGCCGAGAAAGTGATCCCAGCT
GCAGACCTCTCTGAGCAGATCTCCACTGCGGGCACTGAAGCCTCAGGCACCGGCAACATG
AAGTTCATGCTCAACGGGGCTCTGACCATTGGCACCATGGACGGGGCCAATGTGGAGATG
GCAGAAGAGGCGGGAGAGGAAAACTTCTTCATCTTTGGCATGCGGGTGGAGGATGTGGAT
AAGCTTGACCAAAGAGGGTACAATGCCCAGGAGTACTACGATCGCATTCCTGAGCTTCGG
CAGGTCATTGAGCAGCTGAGCAGTGGCTTCTTCTCCCCCAAACAACCCGACCTGTTCAAG
GACATTGTCAATATGCTCATGCACCATGACCGGTTTAAAGTCTTCGCAGATTATGAAGAC
TACATTAAATGCCAGGAGAAAGTCAGCGCCTGGTACAAGAACCCAAGAGAGTGGACGCGG
ATGGTGATCCGGAACATAGCCACTTCTGGCAAGTTCTCCAGTGACCGCACCATTGCCCAG
TATGCCCGGGAGATCTGGGGTGTGGAGCCTTCCCGCCAGCGCCTGCCAGCCCCGGATGAG
GCCATCTGA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
M32598

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_16_Locus:
11q12-q13.2

# Metabolic_Enzyme_16_SNPs:
rs483962; rs489192; rs686171; rs547066; rs477549; rs565688; rs490980; rs7938455; rs592521; rs589691; rs625172; rs592532; rs506354; rs532747; rs592546; rs474006; rs7126110; rs2959652; rs566653; rs630966; rs637332; rs11821081; rs604595; rs11231866; rs2230309; rs1212604; rs11231865; rs1056780; rs28940587; rs669572; rs12278323; rs9704315; rs34267133; rs3202054; rs576632; rs34991365; rs2071320; rs34447097; rs34154523; rs608261; rs28398896; rs1207113; rs550545; rs555974; rs7114931; rs569200; rs608257; rs7104895; rs34195091; rs35447888; rs34978393; rs2071318; rs11308610; rs12364023; rs2284302; rs34338262; rs35958437; rs35091627; rs35071540; rs1803954; rs1804549; rs2073797; rs2073798; rs2277308; rs2277309; rs2301563; rs2904961; rs2959650; rs3168088; rs3759049; rs3759051; rs3759052; rs3891505; rs484886; rs523200; rs546323; rs547280; rs550930; rs561158; rs588139; rs610637; rs620006; rs637732; rs681791

# Metabolic_Enzyme_16_General_References:
3447177; 3840433; 3466902; 8316268; 8535454; 7603523; 9506549; 10417800; 10382911; 10382912; 10681080; 10590419; 10714589; 10899452; 11706962; 12031624

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5869

# Metabolic_Enzyme_17_Name:
AMP deaminase 3

# Metabolic_Enzyme_17_Synonyms:
AMP deaminase isoform E; Erythrocyte AMP deaminase

# Metabolic_Enzyme_17_Gene_Name:
AMPD3

# Metabolic_Enzyme_17_Protein_Sequence:
>AMP deaminase 3
MPRQFPKLNISEVDEQVRLLAEKVFAKVLREEDSKDALSLFTVPEDCPIGQKEAKERELQ
KELAEQKSVETAKRKKSFKMIRSQSLSLQMPPQQDWKGPPAASPAMSPTTPVVTGATSLP
TPAPYAMPEFQRVTISGDYCAGITLEDYEQAAKSLAKALMIREKYARLAYHRFPRITSQY
LGHPRADTAPPEEGLPDFHPPPLPQEDPYCLDDAPPNLDYLVHMQGGILFVYDNKKMLEH
QEPHSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKEL
KSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFD
GLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARM
VKEVARELEESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKVYSPNMRWIIQVPRIYDIF
RSKKLLPNFGKMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDK
SPNPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAF
LTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSL
STDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYY
KEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITALTN

# Metabolic_Enzyme_17_Number_of_Residues:
767

# Metabolic_Enzyme_17_Molecular_Weight:
88813

# Metabolic_Enzyme_17_Theoretical_pI:
6.98

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  AMP deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Not Available

# Metabolic_Enzyme_17_Specific_Function:
AMP deaminase plays a critical role in energy metabolism

# Metabolic_Enzyme_17_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_17_Reaction:
AMP + H2O = IMP + ammonia

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_17_Signals:
None

# Metabolic_Enzyme_17_Transmembrane_Regions:
None

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 3.5.4.6

# Metabolic_Enzyme_17_GenBank_ID_Protein:
219457

# Metabolic_Enzyme_17_SwissProt_ID:
AMPD3_HUMAN (Q01432)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
AMPD3

# Metabolic_Enzyme_17_Geneatlas_id:
AMPD3

# Metabolic_Enzyme_17_hgnc_id:
HGNC:470

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_17_Gene_Sequence:
>2304 bp
ATGCCGCGGCAGTTTCCCAAGCTGAACATCTCTGAAGTGGATGAGCAAGTCCGGCTCCTG
GCGGAGAAGGTGTTTGCTAAAGTGCTCCGAGAAGAGGACAGCAAAGATGCCCTGTCCCTG
TTCACTGTCCCAGAGGACTGCCCCATCGGGCAAAAGGAAGCCAAGGAGAGGGAGCTGCAG
AAGGAGCTGGCAGAGCAGAAGTCTGTGGAGACCGCAAAAAGAAAGAAAAGTTTCAAGATG
ATTCGGTCCCAGTCCCTGTCTCTGCAAATGCCGCCACAGCAAGATTGGAAGGGCCCCCCG
GCAGCCAGTCCGGCCATGTCTCCCACAACCCCTGTGGTCACTGGAGCCACTTCCCTGCCC
ACGCCAGCACCCTATGCCATGCCTGAGTTCCAGCGGGTCACCATCAGCGGAGATTACTGT
GCCGGGATCACTTTGGAGGACTATGAGCAGGCAGCCAAGAGTCTGGCCAAGGCCCTAATG
ATCCGGGAGAAGTATGCGCGGCTCGCCTACCACCGCTTCCCGCGGATCACATCCCAGTAC
CTGGGTCATCCGCGGGCGGATACTGCACCTCCGGAAGAGGGCCTTCCAGACTTCCACCCT
CCTCCACTGCCCCAGGAAGACCCCTACTGCCTGGATGATGCACCCCCCAACCTGGATTAC
TTGGTCCACATGCAGGGGGGCATCCTCTTTGTGTATGATAACAAGAAGATGCTGGAGCAC
CAGGAGCCGCACAGCCTACCCTACCCCGACCTGGAGACCTACACGGTGGACATGAGCCAC
ATCCTGGCTCTCATCACCGATGGCCCCACGAAAACCTATTGTCACCGGCGACTGAACTTT
CTGGAATCCAAGTTCAGCCTTCATGAGATGTTAAACGAAATGTCCGAGTTCAAAGAGTTG
AAGAGTAACCCCCACCGGGACTTCTATAACGTGAGAAAGGTGGACACACACATCCATGCG
GCCGCCTGCATGAACCAAAAGCATCTGCTGCGCTTCATCAAGCACACATACCAGACGGAG
CCTGACAGGACTGTGGCAGAGAAGCGGGGCCGGAAGATCACCCTGCGGCAGGTGTTTGAC
GGCCTGCACATGGACCCCTACGACCTCACTGTGGACTCACTGGATGTCCACGCGGGCCGG
CAGACATTCCACCGCTTTGACAAGTTCAACTCCAAATACAACCCTGTGGGGGCCAGTGAG
CTGCGTGACCTGTATTTGAAAACTGAAAACTATCTGGGAGGAGAGTACTTTGCTCGGATG
GTCAAGGAGGTTGCCCGGGAGCTGGAGGAGAGCAAGTACCAGTACTCAGAGCCACGGCTC
TCCATCTACGGCCGCAGTCCTGAGGAGTGGCCCAACCTGGCCTACTGGTTCATCCAGCAC
AAGGTCTACTCTCCCAACATGCGCTGGATCATCCAGGTGCCCCGGATTTATGACATATTT
AGGTCAAAGAAGCTGCTGCCAAACTTTGGGAAGATGCTGGAGAACATCTTCCTGCCCCTT
TTCAAGGCCACTATCAACCCCCAAGATCATCGAGAGCTTCACCTCTTCCTTAAATATGTG
ACGGGGTTTGACAGCGTGGATGATGAGTCCAAGCACAGCGACCACATGTTTTCCGACAAG
AGCCCAAACCCGGACGTCTGGACCAGTGAGCAGAACCCACCCTACAGCTACTACCTGTAC
TACATGTATGCCAACATCATGGTGCTCAACAACCTCCGCAGGGAGCGCGGCCTGAGCACG
TTCCTGTTCCGGCCGCACTGTGGGGAAGCCGGCTCCATCACCCACCTGGTGTCTGCCTTC
CTCACTGCTGACAACATTTCCCACGGGCTGCTCCTCAAGAAGAGTCCGGTATTGCAGTAT
CTCTACTACCTTGCTCAGATCCCCATTGCCATGTCTCCTCTTAGCAACAACAGTTTGTTC
CTCGAATATTCCAAGAACCCTCTGAGGGAATTCCTACACAAGGGACTGCATGTTTCTCTT
TCCACCGATGACCCCATGCAGTTCCACTACACGAAGGAAGCACTTATGGAAGAATATGCC
ATTGCAGCTCAAGTGTGGAAGCTGAGCACCTGCGACCTGTGTGAGATCGCCAGGAACAGC
GTGCTGCAGAGCGGCCTCTCGCATCAGGAAAAGCAAAAGTTTCTGGGACAAAATTATTAT
AAAGAAGGACCTGAAGGAAATGATATTCGAAAGACAAATGTGGCTCAGATCCGGATGGCA
TTCCGATATGAGACCTTATGCAATGAGCTCAGCTTCCTGTCTGATGCTATGAAATCAGAA
GAGATCACCGCCTTGACCAACTAG

# Metabolic_Enzyme_17_GenBank_ID_Gene:
D12775

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_17_Locus:
11p15

# Metabolic_Enzyme_17_SNPs:
rs11042836; rs36003153; rs3741041; rs16907852; rs34319136; rs11820856; rs899013; rs899011; rs899010; rs1037998; rs936513; rs936514; rs9292; rs1545743; rs7109334; rs11822997; rs930672; rs7416; rs2071020; rs7123980; rs7124144; rs2071019; rs1466426; rs2071018; rs7113101; rs1001118; rs7122280; rs11042840; rs10840419; rs3741037; rs10437597; rs10840427; rs3891547; rs2071017; rs11826750; rs10840429; rs11042854; rs12419888; rs12795565; rs11042830; rs10770120; rs11042841; rs3802917; rs11042846; rs3741038; rs11602933; rs11042853; rs7943804; rs11042849; rs17401498; rs7105307; rs11601268; rs7128132; rs12271597; rs11042855; rs11042833; rs4910146; rs7107588; rs7125606; rs12416948; rs6484336; rs4910140; rs10840424; rs11042850; rs16907878; rs11042842; rs10840425; rs11042834; rs16907858; rs11042828; rs11042848; rs899014; rs11042856; rs7127884; rs1466427; rs7124537; rs10770122; rs7934278; rs2071016; rs7125888; rs10840431; rs4910143; rs11042832; rs11042851; rs12800954; rs12284970; rs4910141; rs11042864; rs6484302; rs7934815; rs11042839; rs16907891; rs12421214; rs16907836; rs16907914; rs16907919; rs10840428; rs3741043; rs7110563; rs3741039; rs11042831; rs4910144; rs4909930; rs10770119; rs7114333; rs17310342; rs11042852; rs12290824; rs7949917; rs10840420; rs11042859; rs11042843; rs7944154; rs4909932; rs10840430; rs11042847; rs16907868; rs7101748; rs10840422; rs922360; rs10770118; rs10840421; rs16907909; rs16907896; rs7130140; rs16907917; rs7101934; rs11042835; rs12418145; rs11042844; rs11042863; rs10840423; rs7932321; rs4909931; rs7950039; rs4909928; rs7929999; rs4909929; rs7111970; rs12161765; rs6484290; rs7112321; rs6484291; rs4910139; rs3741040; rs12418097; rs1803101; rs416372; rs11278140; rs10592594; rs34205084; rs10666578; rs376859; rs35285382; rs35234722; rs34276239; rs2403330; rs433847; rs35548473; rs922359; rs35027484; rs5029459; rs34686247; rs11042817; rs2169594; rs36117985; rs28403593; rs12360830; rs35815414; rs28403594; rs35417007; rs34947038; rs11042816; rs34448488; rs34793322; rs11455471; rs7120456; rs12804742; rs35753139; rs12789944; rs12295824; rs35307925; rs35469290; rs11042827; rs11042815; rs12285554; rs10770121; rs11042837; rs10437667; rs389793; rs4909933; rs12291731; rs411593; rs12291443; rs7937616; rs11042857; rs12295125; rs5789638; rs11042813; rs34796012; rs34400211; rs10466517; rs11327316; rs35172583; rs12284303; rs10466406; rs12287821; rs36106536; rs7107965; rs11042812; rs35535464; rs36075284; rs12271609; rs446512; rs11042826; rs10466515; rs12221503; rs12293113; rs10840426; rs11042845; rs10743142; rs11042862; rs403952; rs34388590; rs34972496; rs34843534; rs12790244; rs7119606; rs11522665; rs10466514; rs12292471; rs35410520; rs12575256; rs12786914; rs12224969; rs12287504; rs35022461; rs35501680; rs34957142; rs4910142; rs12184411; rs11042860; rs16907904; rs35803105; rs34769794; rs34045306; rs35148074; rs11346179; rs11042838; rs34159907; rs4910147; rs11279688; rs34735568; rs35724616; rs10466404; rs35916834; rs7937988; rs35909829; rs12803441; rs4909934; rs4369398; rs7951269; rs11042861; rs34779745; rs34942282; rs11530493; rs11820349; rs9736934; rs11042829; rs35114038; rs10466516; rs12802491; rs12284175; rs10709823; rs11042818; rs36119682; rs35629432; rs11042858; rs12291294; rs34456454; rs36120251; rs11042814; rs11042811; rs11042825; rs36032769; rs7107565; rs7937289; rs7107698; rs7124271; rs10643285; rs36206458; rs8181594; rs7938316; rs11042810; rs10590775; rs1043778; rs10500725; rs1074375; rs10770123; rs10840415; rs10840416; rs10840417; rs10840418; rs11042805; rs11042806; rs11042865; rs11042866; rs11042867; rs11042868; rs11602469; rs11607008; rs12164827; rs12225339; rs12280618; rs12290357; rs12363993; rs12448; rs12789639; rs16907826; rs1870951; rs3177103; rs3741036; rs374925; rs382044; rs383090; rs394242; rs411783; rs4146830; rs428325; rs446762; rs4910149; rs4910150; rs570362; rs6484281; rs677322; rs7119498; rs7939845; rs7948437; rs899012; rs9971562

# Metabolic_Enzyme_17_General_References:
1420359; 1400401; 8611627; 8004104

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5958

# Metabolic_Enzyme_18_Name:
GMP reductase 1

# Metabolic_Enzyme_18_Synonyms:
Guanosine 5'-monophosphate oxidoreductase 1; Guanosine monophosphate reductase 1

# Metabolic_Enzyme_18_Gene_Name:
GMPR

# Metabolic_Enzyme_18_Protein_Sequence:
>GMP reductase 1
MPRIDADLKLDFKDVLLRPKRSSLKSRAEVDLERTFTFRNSKQTYSGIPIIVANMDTVGT
FEMAAVMSQHSMFTAIHKHYSLDDWKLFATNHPECLQNVAVSSGSGQNDLEKMTSILEAV
PQVKFICLDVANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGV
GPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCPGDVAKAFGAGADFVM
LGGMFSGHTECAGEVFERNGRKLKLFYGMSSDTAMNKHAGGVAEYRASEGKTVEVPYKGD
VENTILDILGGLRSTCTYVGAAKLKELSRRATFIRVTQQHNTVFS

# Metabolic_Enzyme_18_Number_of_Residues:
345

# Metabolic_Enzyme_18_Molecular_Weight:
37419

# Metabolic_Enzyme_18_Theoretical_pI:
7.08

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on NADH or NADPH
Function:  oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor
Function:  GMP reductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_18_Specific_Function:
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides

# Metabolic_Enzyme_18_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_18_Reaction:
inosine 5'-phosphate + ammonia + NADP+ = guanosine 5'-phosphate + NADPH + H+

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF00478:IMPDH

# Metabolic_Enzyme_18_Signals:
None

# Metabolic_Enzyme_18_Transmembrane_Regions:
None

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 1.7.1.7

# Metabolic_Enzyme_18_GenBank_ID_Protein:
529232

# Metabolic_Enzyme_18_SwissProt_ID:
GMPR1_HUMAN (P36959)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
GMPR

# Metabolic_Enzyme_18_Geneatlas_id:
GMPR

# Metabolic_Enzyme_18_hgnc_id:
HGNC:4376

# Metabolic_Enzyme_18_PDB_ID:
2BLE

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Not Available

# Metabolic_Enzyme_18_Gene_Sequence:
>87 bp
ATGCCCCGCATAGATGCGGACCTCAAGCTCGACTTCAAGGATGTCCTGCTCCGACCTAAG
CGGAGCAGCCTCAAGAGCCGAGCCGAG

# Metabolic_Enzyme_18_GenBank_ID_Gene:
L35304

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_18_Locus:
6p23

# Metabolic_Enzyme_18_SNPs:
Not Available

# Metabolic_Enzyme_18_General_References:
2758468; 1661705; 14574404; 1757097

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
6164

# Metabolic_Enzyme_19_Name:
Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

# Metabolic_Enzyme_19_Synonyms:
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR transformylase; IMP cyclohydrolase; Inosinicase; IMP synthetase; ATIC]

# Metabolic_Enzyme_19_Gene_Name:
ATIC

# Metabolic_Enzyme_19_Protein_Sequence:
>Bifunctional purine biosynthesis protein PURH Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase
MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEM
LGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEA
VEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFT
HTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINL
CDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPIS
AAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNG
NYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIV
ATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKT
GVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDA
FFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH

# Metabolic_Enzyme_19_Number_of_Residues:
592

# Metabolic_Enzyme_19_Molecular_Weight:
64616

# Metabolic_Enzyme_19_Theoretical_pI:
6.70

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  glycine hydroxymethyltransferase activity
Function:  hydroxymethyl-, formyl- and related transferase activity
Function:  phosphoribosylaminoimidazolecarboxamide formyltransferase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  cyclohydrolase activity
Function:  IMP cyclohydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_19_Specific_Function:
10-formyltetrahydrofolate + 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

# Metabolic_Enzyme_19_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_19_Reaction:
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF01808:AICARFT_IMPCHas;
PF02142:MGS

# Metabolic_Enzyme_19_Signals:
None

# Metabolic_Enzyme_19_Transmembrane_Regions:
None

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 2.1.2.3;EC 3.5.4.10

# Metabolic_Enzyme_19_GenBank_ID_Protein:
1263196

# Metabolic_Enzyme_19_SwissProt_ID:
PUR9_HUMAN (P31939)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
ATIC

# Metabolic_Enzyme_19_Geneatlas_id:
ATIC

# Metabolic_Enzyme_19_hgnc_id:
HGNC:794

# Metabolic_Enzyme_19_PDB_ID:
1P4R

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_19_Gene_Sequence:
>1776 bp
ATGTCTTCTCTCTCAGCCTTATTTAGTGTCTCTGACAAAACCGGCCTTGTGGAATTTGCA
AGAAACCTGACCGCTCTTGGTTTGAACCTGGTCGCTTCCGGAGGGACTGCAAAAGCTCTC
AGGGATGCTGGTCTGGCAGTCAGAGATGTCTCTGAGTTGACGGGATTTCCTGAAATGTTG
GGGGGACGTGTGAAAACTTTGCATCCTGCAGTCCATGCTGGAATCCTAGCTCGTAATATT
CCAGAAGATAATGCTGACATGGCCAGACTTGATTTCAATCTTATAAGAGTTGTCGCCTGC
AATCTCTATCCCTTTGTAAAGACAGTGGCTTCTCCAGGTGTAACTGTTGAGGAGGCTGTG
GAGCAAATTGACATTGGTGGAGTAACCTTACTGAGAGCTGCAGCCAAAAACCACGCTCGA
GTGACAGTGGTGTGTGAACCAGAGGACTATGTGGTGGTGTCCACGGAGATGCAGAGCTCC
GAGAGTAAGGGCACCTCCTTGGAGACTAGACGCCAGTTAGCCTTGAAGGCATTCACTCAT
ACGGCACAATATGATGAAGCAATTTCAGATTATTTCAGGAAACAGTACAGCAAAGGCGTA
TCTCAGATGCCCTTGAGATATGGAATGAACCCACATCAGACCCCTGCCCAGCTGTACACA
CTGCAGCCCAAGCTTCCCATCACAGTTCTAAATGGAGCCCCTGGATTTATAAACTTGTGC
GATGCTTTGAACGCCTGGCAGCTGGTGAAGGAACTCAAGGAGGCTTTAGGTATTCCAGCC
GCTGCCTCTTTCAAACATGTCAGCCCAGCAGGTGCTGCTGTTGGAATTCCACTCAGTGAA
GATGAGGCCAAAGTCTGCATGGTTTATGATCTCTATAAAACCCTCACACCCATCTCAGCG
GCATATGCAAGAGCAAGAGGGGCTGATAGGATGTCTTCATTTGGTGATTTTGTTGCATTG
TCTGATGTTTGTGATGTACCAACTGCAAAAATTATTTCCAGAGAAGTATCTGATGGTATA
ATTGCCCCAGGATATGAAGAAGAAGCCTTGACAATACTTTCCAAAAAGAAAAATGGAAAC
TATTGTGTCCTTCAGATGGACCAATCTTACAAACCAGATGAAAATGAAGTTCGAACTCTC
TTTGGTCTTCATTTAAGCCAGAAGAGAAATAATGGTGTCGTCGACAAGTCATTATTTAGC
AATGTTGTTACCAAAAATAAAGATTTGCCAGAGTCTGCCCTCCGAGACCTCATCGTAGCC
ACCATTGCTGTCAAGTACACTCAGTCTAACTCTGTGTGCTACGCCAAGAACGGGCAGGTT
ATCGGCATTGGAGCAGGACAGCAGTCTCGTATACACTGCACTCGCCTTGCAGGAGATAAG
GCAAACTATTGGTGGCTTAGACACCATCCACAAGTGCTTTCGATGAAGTTTAAAACAGGA
GTGAAGAGAGCAGAAATCTCCAATGCCATCGATCAATATGTGACTGGAACCATTGGCGAG
GATGAAGATTTGATAAAGTGGAAGGCACTGTTTGAGGAAGTCCCTGAGTTACTCACTGAG
GCAGAGAAGAAGGAATGGGTTGAGAAACTGACTGAAGTTTCTATCAGCTCTGATGCCTTC
TTCCCTTTCCGAGATAACGTAGACAGAGCTAAAAGGAGTGGTGTGGCGTACATTGCGGCT
CCCTCCGGTTCTGCTGCTGACAAAGTTGTGATTGAGGCCTGCGACGAACTGGGAATCATC
CTCGCTCATACGAACCTTCGGCTCTTCCACCACTGA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
U37436

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_19_Locus:
2q35

# Metabolic_Enzyme_19_SNPs:
rs2372536; rs1404772; rs1983462; rs1997059; rs2030774; rs10932606; rs6757920; rs4316940; rs10932608; rs3821354; rs2177735; rs957480; rs4673990; rs4673991; rs4673993; rs7563206; rs1880586; rs6737407; rs6707934; rs13010249; rs7585489; rs6737909; rs12477903; rs12995526; rs10197559; rs13005416; rs6713365; rs17514110; rs16853821; rs12477799; rs11685089; rs6435900; rs10932607; rs17448447; rs11892429; rs4673992; rs3772078; rs16853826; rs6435899; rs3821353; rs16853834; rs12477966; rs7586969; rs4672765; rs4672768; rs12466139; rs16853829; rs4672763; rs12474089; rs16853813; rs13002576; rs11679882; rs12471482; rs10203444; rs11682496; rs3772077; rs1568872; rs12620277; rs7594345; rs10201264; rs4673989; rs13002052; rs4629155; rs7563274; rs4673986; rs2372537; rs10191233; rs16853774; rs6760067; rs16853830; rs6714224; rs7605074; rs4672767; rs13002318; rs6740943; rs16853782; rs10179873; rs7608431; rs7596330; rs12469855; rs16853769; rs16853786; rs16853823; rs4673987; rs10498036; rs12469250; rs11690946; rs10932610; rs28366034; rs4535042; rs10175961; rs1803201; rs11550204; rs3772079; rs11550203; rs11550205; rs10714012; rs6755790; rs6751557; rs35280333; rs6435897; rs34797859; rs3051899; rs12990072; rs35409099; rs35740451; rs28661573; rs35561816; rs6435901; rs34416522; rs34153392; rs12990040; rs11673966; rs12477890; rs2372538; rs6709785; rs17448050; rs35223091; rs11352914; rs7608331; rs34906748; rs10932609; rs13029082; rs4672766; rs11331814; rs13421420; rs10692917; rs34404425; rs7558689; rs11285874; rs13387522; rs12995105; rs35473543; rs35519686; rs10600658; rs35425452; rs11903294; rs2177737; rs34900850; rs13004562; rs7594036; rs13005172; rs34599566; rs35373619; rs41501252; rs11334839; rs34643540; rs6751963; rs6721444; rs12105862; rs1474397; rs34159745; rs34790659; rs6740572; rs34779930; rs28586952; rs13404113; rs10592022; rs4672764; rs12464837; rs11268918; rs10932611; rs13029548; rs13401084; rs11454824; rs33971143; rs11271979; rs13400971; rs34338408; rs34845354; rs5838500; rs7593545; rs2372539; rs28366035; rs13017013; rs13016466; rs13023857; rs10180997; rs10201735; rs12997662; rs12999909; rs13027307; rs6706415; rs6725921; rs7562597; rs7578850; rs7578865; rs7588799; rs7594283; rs7604984

# Metabolic_Enzyme_19_General_References:
8567683; 8867801; 9378707; 1286667

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
5237

# Metabolic_Enzyme_20_Name:
Cytosolic purine 5'-nucleotidase

# Metabolic_Enzyme_20_Synonyms:
5'-nucleotidase cytosolic II

# Metabolic_Enzyme_20_Gene_Name:
NT5C2

# Metabolic_Enzyme_20_Protein_Sequence:
>Cytosolic purine 5'nucleotidase
MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVY
KSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLV
CAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTS
CETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMK
EVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGT
VLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKS
KKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQ
RRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAA
HVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLA
PQEITHCHDEDDDEEEEEEEE

# Metabolic_Enzyme_20_Number_of_Residues:
561

# Metabolic_Enzyme_20_Molecular_Weight:
64970

# Metabolic_Enzyme_20_Theoretical_pI:
6.05

# Metabolic_Enzyme_20_GO_Classification:
Not Available

# Metabolic_Enzyme_20_General_Function:
Not Available

# Metabolic_Enzyme_20_Specific_Function:
May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides

# Metabolic_Enzyme_20_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_20_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF05761:5_nucleotid

# Metabolic_Enzyme_20_Signals:
None

# Metabolic_Enzyme_20_Transmembrane_Regions:
None

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_20_GenBank_ID_Protein:
633071

# Metabolic_Enzyme_20_SwissProt_ID:
5NTC_HUMAN (P49902)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
NT5C2

# Metabolic_Enzyme_20_Geneatlas_id:
NT5C2

# Metabolic_Enzyme_20_hgnc_id:
HGNC:8022

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_20_Gene_Sequence:
>1686 bp
ATGTCGACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGAT
AAGCATGCCCTGAAAAAGTATCGTCGAGAAGCCTATCATCGGGTGTTTGTGAACCGAAGT
TTAGCAATGGAAAAGATAAAGTGTTTTGGTTTTGATATGGATTATACCCTTGCTGTGTAC
AAGTCCCCAGAGTATGAGTCCCTTGGTTTTGAGCTTACTGTGGAGAGATTAGTTTCTATT
GGCTATCCCCAGGAGTTGCTCAGCTTTGCTTATGATTCTACATTCCCTACCAGGGGACTT
GTCTTTGACACACTGTATGGAAATCTTTTGAAAGTCGATGCCTATGGAAACCTCTTGGTC
TGTGCACATGGATTTAACTTTATAAGGGGACCAGAAACTAGAGAACAGTATCCAAATAAA
TTTATCCAGCGAGATGATACTGAAAGATTTTACATTCTGAACACACTATTCAACCTACCA
GAGACCTACCTGTTGGCCTGCCTAGTAGATTTTTTTACTAATTGTCCCAGATATACCAGT
TGTGAAACAGGATTTAAAGATGGGGACCTCTTCATGTCCTACCGGAGTATGTTCCAGGAT
GTAAGAGATGCTGTTGACTGGGTTCATTACAAGGGCTCCCTTAAGGAAAAGACAGTTGAA
AATCTTGAGAAGTATGTAGTCAAAGATGGAAAACTGCCTTTGCTTCTGAGCCGGATGAAG
GAAGTAGGGAAAGTATTTCTTGCTACCAACAGTGACTATAAATATACAGATAAAATTATG
ACTTACCTGTTTGACTTCCCACATGGCCCCAAGCCTGGGAGCTCCCATCGACCATGGCAG
TCCTACTTTGACTTGATCTTGGTGGATGCACGGAAACCACTCTTTTTTGGAGAAGGCACA
GTACTGCGTCAGGTGGATACTAAAACTGGCAAGCTGAAAATTGGTACCTACACAGGGCCC
CTACAGCATGGTATCGTCTACTCAGGAGGTTCTTCTGATACGATCTGTGACCTGTTGGGA
GCCAAGGGAAAAGACATTTTGTATATTGGAGATCACATTTTTGGGGACATTTTAAAATCA
AAGAAACGGCAAGGGTGGCGAACTTTTTTGGTGATTCCTGAACTCGCACAGGAGCTACAT
GTCTGGACTGACAAGAGTTCACTTTTCGAAGAACTTCAGAGCTTGGATATTTTCTTGGCT
GAACTCTACAAGCATCTTGACAGCAGTAGCAATGAGCGTCCAGACATCAGTTCCATCCAG
AGACGTATTAAGAAAGTAACTCATGACATGGACATGTGCTATGGGATGATGGGAAGCCTG
TTTCGCAGTGGCTCCCGGCAGACCCTTTTTGCCAGTCAAGTGATGCGTTATGCTGACCTC
TATGCAGCATCTTTCATCAACCTGCTGTATTACCCTTTCAGCTACCTCTTCAGGGCTGCC
CATGTCTTGATGCCTCATGAATCAACGGTGGAGCACACACACGTAGATATCAATGAGATG
GAGTCTCCTCTTGCCACCCGGAACCGCACATCAGTGGATTTCAAAGACACTGACTACAAG
CGGCACCAGCTGACACGGTCAATTAGTGAGATTAAACCTCCCAACCTCTTCCCACTGGCC
CCCCAGGAAATTACACACTGCCATGACGAAGATGATGATGAAGAGGAGGAGGAGGAGGAA
GAATAA

# Metabolic_Enzyme_20_GenBank_ID_Gene:
D38524

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_20_Locus:
10q24.32-q24.33

# Metabolic_Enzyme_20_SNPs:
rs12262171; rs3740387; rs12253627; rs10786736; rs8139; rs7917650; rs10786741; rs7920251; rs10430665; rs7916854; rs12573199; rs11191598; rs1163238; rs12573200; rs10883843; rs7092407; rs12573221; rs4917997; rs11191593; rs11191596; rs10786744; rs1163236; rs10883842; rs10786742; rs10786743; rs7075552; rs7077097; rs2863728; rs3758543; rs7077291; rs10748838; rs3087681; rs12240508; rs732998; rs10883830; rs7899084; rs2274340; rs2182348; rs2066322; rs7908960; rs7912517; rs7067970; rs3740386; rs7896547; rs11191554; rs1163249; rs2281877; rs2863727; rs3781281; rs2274341; rs2148198; rs7897663; rs3781282; rs10883832; rs1926029; rs1935323; rs1926030; rs746293; rs6584539; rs2066323; rs9919482; rs3740385; rs12773916; rs12414232; rs10786737; rs12413046; rs12412038; rs2274339; rs11598702; rs1541213; rs11191580; rs11191553; rs10509765; rs10509766; rs3977751; rs12220375; rs4917996; rs7896433; rs6584540; rs1926037; rs3736922; rs11191577; rs2148197; rs11191561; rs7080935; rs11191555; rs10883833; rs12219304; rs1926036; rs7913920; rs10883834; rs11191558; rs11191582; rs11191589; rs10883831; rs12220743; rs10786738; rs11191560; rs10748837; rs11191578; rs3781280; rs7896519; rs12217501; rs11191573; rs7067741; rs6584541; rs7067663; rs2148200; rs10883840; rs11191583; rs12415199; rs9919485; rs11191557; rs17094683; rs7895154; rs12355120; rs2153774; rs10786739; rs7915816; rs7081075; rs1807298; rs3861984; rs11191572; rs12571568; rs12416331; rs11191586; rs10883839; rs12766205; rs1163239; rs10883837; rs11191584; rs1163247; rs17115452; rs11191556; rs7909022; rs12775302; rs9633712; rs11191581; rs11191576; rs10883836; rs11191549; rs7095304; rs10883845; rs11191550; rs11191548; rs11191602; rs10748839; rs1141101; rs1055812; rs1141100; rs1141098; rs1141099; rs34351688; rs34394526; rs34058246; rs11191594; rs35224704; rs34747231; rs12774207; rs11191595; rs34699185; rs11280184; rs1163237; rs7073259; rs34064597; rs11191601; rs35525740; rs35291480; rs12264098; rs35978588; rs12241986; rs7091462; rs12774182; rs34756486; rs35695488; rs12252236; rs3834416; rs11191600; rs34136949; rs7080242; rs12763243; rs34003851; rs11191585; rs11191551; rs36111455; rs34966121; rs35464534; rs35541240; rs11191571; rs35913488; rs34223002; rs11440429; rs41287482; rs35653865; rs34963818; rs11191559; rs11191568; rs35436872; rs17795366; rs1163246; rs34060908; rs34963563; rs34915846; rs12780509; rs2153773; rs34211645; rs3736924; rs34758128; rs36059537; rs35302704; rs12255989; rs34104646; rs11191574; rs11191564; rs35745742; rs34644789; rs5787481; rs34863357; rs11191590; rs12774840; rs2148196; rs12763944; rs3215816; rs34207290; rs35752695; rs34445719; rs28419708; rs4421684; rs28516969; rs12265498; rs12767422; rs12772228; rs34908445; rs11191570; rs17115449; rs35195396; rs12243923; rs10883835; rs12779263; rs11302933; rs7091173; rs11375439; rs7071103; rs35146429; rs35338839; rs34268365; rs34130454; rs35898850; rs3861983; rs28404041; rs35621207; rs3736923; rs5787482; rs7075048; rs34307431; rs35348020; rs34349473; rs1773930; rs11191566; rs34870452; rs35078544; rs35123178; rs12265545; rs1163241; rs3949893; rs7904067; rs12775841; rs35821867; rs12775904; rs7915032; rs5028036; rs35254502; rs1163248; rs35365027; rs34876862; rs11191565; rs12772280; rs10709724; rs35085852; rs35351555; rs12774513; rs10710371; rs11296588; rs12243903; rs28605898; rs34241930; rs34549427; rs11451961; rs34403968; rs12761657; rs34397864; rs3062737; rs36092020; rs35109679; rs34011916; rs34435560; rs11191562; rs4917383; rs34067380; rs34202831; rs11191563; rs2148199; rs34133379; rs35763505; rs12414385; rs1163240; rs12262258; rs11191588; rs34664715; rs12414374; rs35133717; rs3837340; rs10614009; rs2153772; rs11191587; rs11403586; rs11191575; rs1060240; rs34588165; rs11191552; rs41317254; rs1163245; rs1064099; rs12268552; rs34833988; rs11191603; rs12253716; rs12412924; rs3841710; rs34551510; rs12246784; rs12781668; rs1064098; rs10458729; rs10786740; rs10786745; rs10883829; rs10883841; rs11191547; rs1163235; rs12261294; rs12571345; rs12785223; rs17115427; rs4307650; rs4917382; rs4917995; rs7074395; rs7092200; rs726010; rs763914; rs7921996; rs943035

# Metabolic_Enzyme_20_General_References:
7999131

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
5234

# Metabolic_Enzyme_21_Name:
5'(3')-deoxyribonucleotidase, cytosolic type

# Metabolic_Enzyme_21_Synonyms:
Cytosolic 5',3'-pyrimidine nucleotidase; Deoxy-5'-nucleotidase 1; dNT-1

# Metabolic_Enzyme_21_Gene_Name:
NT5C

# Metabolic_Enzyme_21_Protein_Sequence:
>5'3'deoxyribonucleotidase, cytosolic type
MARSVRVLVDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADK
VASVYEAPGFFLDLEPIPGALDAVREMNDLPDTQVFICTSPLLKYHHCVGEKYRWVEQHL
GPQFVERIILTRDKTVVLGDLLIDDKDTVRGQEETPSWEHILFTCCHNRHLVLPPTRRRL
LSWSDNWREILDSKRGAAQRE

# Metabolic_Enzyme_21_Number_of_Residues:
201

# Metabolic_Enzyme_21_Molecular_Weight:
23383

# Metabolic_Enzyme_21_Theoretical_pI:
6.63

# Metabolic_Enzyme_21_GO_Classification:
Not Available

# Metabolic_Enzyme_21_General_Function:
Not Available

# Metabolic_Enzyme_21_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP

# Metabolic_Enzyme_21_Pathway:
Not Available

# Metabolic_Enzyme_21_Reaction:
Not Available

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_21_Signals:
None

# Metabolic_Enzyme_21_Transmembrane_Regions:
None

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_21_GenBank_ID_Protein:
7524492

# Metabolic_Enzyme_21_SwissProt_ID:
NT5C_HUMAN (Q8TCD5)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
NT5C

# Metabolic_Enzyme_21_Geneatlas_id:
NT5C

# Metabolic_Enzyme_21_hgnc_id:
HGNC:17144

# Metabolic_Enzyme_21_PDB_ID:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_21_Gene_Sequence:
>606 bp
ATGGCGCGGAGCGTGCGCGTGCTGGTGGACATGGACGGCGTCCTGGCCGACTTCGAGGCC
GGCCTCCTGCGGGGCTTCCGCCGCCGCTTCCCTGAGGAGCCGCACGTGCCGCTGGAGCAA
CGCCGCGGCTTCCTGGCCCGCGAGCAGTACCGCGCCCTGCGGCCCGACCTGGCGGATAAA
GTGGCCAGTGTGTACGAAGCCCCGGGCTTTTTCCTGGACCTGGAGCCCATCCCGGGAGCC
TTGGACGCTGTGCGGGAGATGAACGACCTACCGGACACGCAGGTCTTCATCTGCACCAGC
CCCCTGCTGAAGTACCACCACTGTGTGGGTGAGAAGTACCGCTGGGTGGAGCAGCACCTG
GGGCCCCAGTTCGTAGAACGAATTATCCTGACAAGGGACAAGACGGTGGTCTTGGGGGAC
CTGCTCATTGATGACAAGGACACAGTTCGAGGCCAGGAGGAGACCCCAAGCTGGGAGCAC
ATCTTGTTCACCTGCTGCCACAATCGGCACCTGGTCCTGCCCCCGACAAGGAGACGGCTG
CTCTCCTGGAGTGACAACTGGAGGGAGATCTTAGATAGCAAGCGCGGAGCTGCGCAGCGG
GAATGA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
AF154829

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_21_Locus:
17q25.1

# Metabolic_Enzyme_21_SNPs:
rs4788867; rs11868451; rs3736076; rs3736075; rs12453556; rs4789144; rs11652099; rs4789143; rs11541956; rs12945569; rs3188816; rs12946860; rs1048779; rs12943507; rs34746270; rs11541955; rs12945517; rs9910084; rs34454120; rs7406461; rs4788868; rs11868212; rs1551966; rs2291027; rs2291028; rs34338273; rs3752801; rs4412997; rs4789145; rs750843; rs750844; rs899316; rs899317

# Metabolic_Enzyme_21_General_References:
10681516; 12234672

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
5318

# Metabolic_Enzyme_22_Name:
Ectonucleoside triphosphate diphosphohydrolase 3

# Metabolic_Enzyme_22_Synonyms:
NTPDase 3; Ecto-ATP diphosphohydrolase; ATPDase; Ecto-apyrase; CD39 antigen-like 3; HB6

# Metabolic_Enzyme_22_Gene_Name:
ENTPD3

# Metabolic_Enzyme_22_Protein_Sequence:
>Ectonucleoside triphosphate diphosphohydrolase 3
MFTVLTRQPCEQAGLKALYRTPTIIALVVLLVSIVVLVSITVIQIHKQEVLPPGLKYGIV
LDAGSSRTTVYVYQWPAEKENNTGVVSQTFKCSVKGSGISSYGNNPQDVPRAFEECMQKV
KGQVPSHLHGSTPIHLGATAGMRLLRLQNETAANEVLESIQSYFKSQPFDFRGAQIISGQ
EEGVYGWITANYLMGNFLEKNLWHMWVHPHGVETTGALDLGGASTQISFVAGEKMDLNTS
DIMQVSLYGYVYTLYTHSFQCYGRNEAEKKFLAMLLQNSPTKNHLTNPCYPRDYSISFTM
GHVFDSLCTVDQRPESYNPNDVITFEGTGDPSLCKEKVASIFDFKACHDQETCSFDGVYQ
PKIKGPFVAFAGFYYTASALNLSGSFSLDTFNSSTWNFCSQNWSQLPLLLPKFDEVYARS
YCFSANYIYHLFVNGYKFTEETWPQIHFEKEVGNSSIAWSLGYMLSLTNQIPAESPLIRL
PIEPPVFVGTLAFFTAAALLCLAFLAYLCSATRRKRHSEHAFDHAVDSD

# Metabolic_Enzyme_22_Number_of_Residues:
529

# Metabolic_Enzyme_22_Molecular_Weight:
59106

# Metabolic_Enzyme_22_Theoretical_pI:
6.40

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Not Available

# Metabolic_Enzyme_22_Specific_Function:
Has a threefold preference for the hydrolysis of ATP over ADP

# Metabolic_Enzyme_22_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_22_Reaction:
ATP + 2 H2O = AMP + 2 phosphate

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF01150:GDA1_CD39

# Metabolic_Enzyme_22_Signals:
1-37

# Metabolic_Enzyme_22_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 3.6.1.5

# Metabolic_Enzyme_22_GenBank_ID_Protein:
3335100

# Metabolic_Enzyme_22_SwissProt_ID:
ENTP3_HUMAN (O75355)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
ENTPD3

# Metabolic_Enzyme_22_Geneatlas_id:
ENTPD3

# Metabolic_Enzyme_22_hgnc_id:
HGNC:3365

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential)

# Metabolic_Enzyme_22_Gene_Sequence:
>1590 bp
ATGTTCACTGTGCTGACCCGCCAACCATGTGAGCAAGCAGGCCTCAAGGCCCTCTACCGA
ACTCCAACCATCATTGCCTTGGTGGTCTTGCTTGTGAGTATTGTGGTACTTGTGAGTATC
ACTGTCATCCAGATCCACAAGCAAGAGGTCCTCCCTCCAGGACTGAAGTATGGTATTGTG
CTGGATGCCGGGTCTTCAAGAACCACAGTCTACGTGTATCAATGGCCAGCAGAAAAAGAG
AATAATACCGGAGTGGTCAGTCAAACCTTCAAATGTAGTGTGAAAGGCTCTGGAATCTCC
AGCTATGGAAATAACCCCCAAGATGTCCCCAGAGCCTTTGAGGAGTGTATGCAAAAAGTC
AAGGGGCAGGTTCCATCCCACCTCCACGGATCCACCCCCATTCACCTGGGAGCCACGGCT
GGGATGCGCTTGCTGAGGTTGCAAAATGAAACAGCAGCTAATGAAGTCCTTGAAAGCATC
CAAAGCTACTTCAAGTCCCAGCCCTTTGACTTTAGGGGTGCTCAAATCATTTCTGGGCAA
GAAGAAGGGGTATATGGATGGATTACAGCCAACTATTTAATGGGAAATTTCCTGGAGAAG
AACCTGTGGCACATGTGGGTGCACCCGCATGGAGTGGAAACCACGGGTGCCCTGGACTTA
GGTGGTGCCTCCACCCAAATATCCTTCGTGGCAGGAGAGAAGATGGATCTGAACACCAGC
GACATCATGCAGGTGTCCCTGTATGGCTACGTATACACGCTCTACACACACAGCTTCCAG
TGCTATGGCCGGAATGAGGCTGAGAAGAAGTTTCTGGCAATGCTCCTGCAGAATTCTCCT
ACCAAAAACCATCTCACCAATCCCTGTTACCCTCGGGATTATAGCATCAGCTTCACCATG
GGCCATGTATTTGATAGCCTGTGCACTGTGGACCAGAGGCCAGAAAGTTATAACCCCAAT
GATGTCATCACTTTTGAAGGAACTGGGGACCCATCTCTGTGTAAGGAGAAGGTGGCTTCC
ATATTTGACTTCAAAGCTTGCCATGATCAAGAAACCTGTTCTTTTGATGGGGTTTATCAG
CCAAAGATTAAAGGGCCATTTGTGGCTTTTGCAGGATTCTACTACACAGCCAGTGCTTTA
AATCTTTCAGGTAGCTTTTCCCTGGACACCTTCAACTCCAGCACCTGGAATTTCTGCTCA
CAGAATTGGAGTCAGCTCCCACTGCTGCTCCCCAAATTTGATGAGGTATATGCCCGCTCT
TACTGCTTCTCAGCCAACTACATCTACCACTTGTTTGTGAACGGTTACAAATTCACAGAG
GAGACTTGGCCCCAAATACACTTTGAAAAAGAAGTGGGGAATAGCAGCATAGCCTGGTCT
CTTGGCTACATGCTCAGCCTGACCAACCAGATCCCAGCTGAAAGCCCTCTGATCCGTCTG
CCCATAGAACCACCTGTCTTTGTGGGCACCCTCGCTTTCTTCACAGTGGCAGCCTTGCTG
TGTCTGGCATTTCTTGCATACCTGTGTTCAGCAACCAGAAGAAAGAGGCACTCCGAGCAT
GCCTTTGACCATGCAGTGGATTCTGACTGA

# Metabolic_Enzyme_22_GenBank_ID_Gene:
AF039917

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_22_Locus:
3p21.3

# Metabolic_Enzyme_22_SNPs:
rs1047855; rs2305521; rs9858868; rs11714871; rs17078798; rs2305522; rs12493020; rs897117; rs1466236; rs6599101; rs6808095; rs9332450; rs6599102; rs954589; rs6783755; rs9848083; rs951560; rs7645864; rs7636719; rs4973999; rs9829800; rs4973997; rs4973898; rs7648952; rs12490249; rs13324109; rs17079011; rs9849348; rs9873394; rs17078941; rs17078813; rs1466237; rs7634375; rs1105745; rs7631893; rs9822909; rs9859026; rs1466238; rs7625736; rs4283549; rs17078812; rs9857824; rs6793596; rs11707673; rs11714032; rs11720360; rs6599100; rs9875245; rs2371185; rs6804157; rs17078914; rs11921197; rs17078916; rs12492035; rs4973994; rs17078921; rs4973989; rs17078959; rs13099333; rs1037516; rs12490275; rs3774805; rs4973998; rs12492777; rs6796122; rs4973993; rs13326389; rs13321169; rs12491944; rs12634013; rs13081891; rs11920596; rs9848049; rs13066971; rs12636697; rs6807397; rs9864380; rs34266806; rs4470483; rs17852714; rs3733167; rs41286046; rs35071108; rs6773917; rs10671439; rs35839072; rs35836679; rs9874499; rs10551054; rs13073943; rs10565031; rs13094752; rs10620040; rs11351492; rs34255517; rs34665572; rs3774806; rs10575365; rs5848563; rs951561; rs13082239; rs3064608; rs11445995; rs9809377; rs35636349; rs35489659; rs4560275; rs6798459; rs10620057; rs13316488; rs13082375; rs6797651; rs6795906; rs13073946; rs3064609; rs41286044; rs35641310; rs35870509; rs13082222; rs13090979; rs9836330; rs34726619; rs28465354; rs10650731; rs9883218; rs9863737; rs9829324; rs1105746; rs5848564; rs9833430; rs9880286; rs9864423; rs3774807; rs28621801; rs34065066; rs6767610; rs11415995; rs3064615; rs35700770; rs5848565; rs9882941; rs34145192; rs34654655; rs10658778; rs11360523; rs9843979; rs36074810; rs9843965; rs13072002; rs35267876; rs41286048; rs9860002; rs9863679; rs13433935; rs35860386; rs9882954; rs11371152; rs9809378; rs28671141; rs28508335; rs34934417; rs6808552; rs10594515; rs9828299; rs1119179; rs12488805; rs12492578; rs12494022; rs2371184; rs6762997; rs6795066; rs7610586; rs7616273; rs7642552; rs9813231; rs9817233; rs9822644; rs9835219; rs9841335; rs9846606; rs9871825; rs9874006; rs9882464

# Metabolic_Enzyme_22_General_References:
9676430; 9675246; 10231536; 11300774

# Metabolic_Enzyme_22_References:
Not Available

# Metabolic_Enzyme_23_ID:
6165

# Metabolic_Enzyme_23_Name:
Inosine-5'-monophosphate dehydrogenase 1

# Metabolic_Enzyme_23_Synonyms:
IMP dehydrogenase 1; IMPDH-I; IMPD 1

# Metabolic_Enzyme_23_Gene_Name:
IMPDH1

# Metabolic_Enzyme_23_Protein_Sequence:
>Inosine5'monophosphate dehydrogenase 1
MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKIT
LKTPLISSPM
DTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPV
VLSPSHTVGDVLEAKMRHGFS
GIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEV
MTPRIELVVAPAGVTLKEANEILQRSKKGKLP
IVNDCDELVAIIARTDLKKNRDYPLAS
KDSQKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNS
VYQIAMVHYIKQKYPH
LQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKV
AEYAR
RFGVPIIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMG
SLDAM
EKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGAR
SLSVLRSMMYSGELKF
EKRTMSAQIEGGVHGLHSYEKRLY

# Metabolic_Enzyme_23_Number_of_Residues:
514

# Metabolic_Enzyme_23_Molecular_Weight:
55407

# Metabolic_Enzyme_23_Theoretical_pI:
6.90

# Metabolic_Enzyme_23_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  IMP dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
Process:  GMP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_23_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_23_Specific_Function:
Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors

# Metabolic_Enzyme_23_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_23_Reaction:
inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF00571:CBS;
PF00478:IMPDH

# Metabolic_Enzyme_23_Signals:
None

# Metabolic_Enzyme_23_Transmembrane_Regions:
None

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 1.1.1.205

# Metabolic_Enzyme_23_GenBank_ID_Protein:
307067

# Metabolic_Enzyme_23_SwissProt_ID:
IMDH1_HUMAN (P20839)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
IMPDH1

# Metabolic_Enzyme_23_Geneatlas_id:
IMPDH1

# Metabolic_Enzyme_23_hgnc_id:
HGNC:6052

# Metabolic_Enzyme_23_PDB_ID:
1JCN

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Not Available

# Metabolic_Enzyme_23_Gene_Sequence:
>1545 bp

ATGGCGGACTACCTGATCAGCGGCGGCACCGGCTACGTGCCCGAGGATGGGCTCACCGC
GCAGCAGCTCT
TCGCCAGCGCCGACGACCTCACCTACAACGACTTCCTGATTCTCCCAG
GATTCATAGACTTCATAGCTGA
TGAGGTGGACCTGACCTCAGCCCTGACCCGGAAGATC
ACGCTGAAGACGCCACTCATCTCCTCCCCCATG
GACACTGTGACAGAGGCTGACATGGC
CATTGCCATGGCTCTGATGGGAGGTATTGGGTTCATTCACCACA
ACTGCACCCCAGAGT
TCCAGGCCAATGAAGTACGCAAGGTCAAGAACTTTGAACAGGGCTTCATCACGGA
CCCT
GTGGTGCTGAGCCCCTCGCACACTGTGGGCGATGTGCTGGAGGCCAAGATGCGGCATGGC
TTCTCT
GGCATCCCCATCACTGAGACGGGCACCATGGGCAGCAAGCTGGTGGGCATCGT
CACCTCCCGAGACATCG
ACTTTCTTGCTGAGAAGGACCACACCACCCTCCTCAGTGAGG
TGATGACGCCAAGGATTGAACTGGTGGT
GGCTCCAGCAGGTGTGACGTTGAAAGAGGCA
AATGAGATCCTGCAGCGTAGCAAGAAAGGGAAGCTGCCT
ATCGTCAATGATTGCGATGA
GCTGGTGGCCATCATCGCCCGCACCGACCTGAAGAAGAATCGAGACTACC
CTCTGGCCT
CCAAGGATTCCCAGAAGCAGCTGCTCTGTGGGGCAGCTGTGGGCACCCGTGAGGATGACA
A
ATACCGTCTGGACCTGCTGACCCAGGCGGGGGTCGACGTCATAGTCTTCCACTCGTCC
CAAGGGAATTCG
GTGTATCAGATCGCCATGGTGCATTACATCAAACAGAAGTACCCCCA
CCTCCAGGTGATTGGGGGGAACG
TGGTGACAGCAGCCCAGGCCAAGAACCTGATTGATG
CTGGTGTGGACGGGCTGCGCGTGGGCATGGGCTG
CGGCTCCATCTGCATCACCCAGGAA
GTGATGGCCTGTGGTCGGCCCCAGGGCACTGCTGTGTACAAGGTG
GCTGAGTATGCCCG
GCGCTTTGGTGTGCCCATCATAGCCGATGGCGGCATCCAGACCGTGGGACACGTGG
TCA
AGGCCCTGGCCCTTGGAGCCTCCACAGTGATGATGGGCTCCCTGCTGGCCGCCACTACGG
AGGCCCC
TGGCGAGTACTTCTTCTCAGACGGGGTGCGGCTCAAGAAGTACCGGGGCATG
GGCTCACTGGATCCCATG
GAGAAGAGCAGCAGCAGCCAGAAACGATACTTCAGCGAGGG
GGATAAAGTGAAGATCGCACAGGGTGTCT
CGGGCTCCATCCAGGACAAAGGATCCATTC
AGAAGTTCGTGCCCTACCTCATAGCAGGCATCCAACACGG
CTGCCAGGATATCGGGGCC
CGCAGCCTGTCTGTCCTTCGGTCCATGATGTACTCAGGAGAGCTCAAGTTT
GAGAAGCG
GACCATGTCGCCCCAGATTGAGGGTGGTGTCCATGGCCTGCACTCTTACGAAAAGCGGCT
GT
ACTGA

# Metabolic_Enzyme_23_GenBank_ID_Gene:
J05272

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_23_Locus:
7q31.3-q32

# Metabolic_Enzyme_23_SNPs:
rs2228075; rs2288550; rs4731449; rs10954184; rs2278293; rs11770116; rs10954183; rs2278294; rs4731448; rs13242340; rs28364722; rs7802305; rs34848853; rs2288553; rs11769333; rs3793165; rs2288548; rs11766548; rs12536006; rs11766743; rs2288549; rs714510; rs11761662; rs714511; rs11773251; rs4731446; rs1042259; rs1042252; rs34724843; rs1042254; rs1042247; rs41281737; rs1042253; rs1803822; rs35970777; rs35916539; rs1042267; rs1803821; rs11549800; rs1042271; rs3838695; rs34600858; rs13311017; rs35521415; rs41281740; rs5887378; rs3793167; rs28580600; rs10247945; rs34272414; rs11291158; rs3838694; rs13307053; rs11451625; rs10273872; rs11407388; rs3793166; rs35501542; rs4731450; rs11562030; rs11417755; rs13312278; rs2288552; rs11388935; rs4731447; rs35241533; rs3793168; rs3793164; rs2288551; rs34587154; rs34995178; rs35132833; rs35456019; rs6948333; rs11763326; rs11773759; rs11980741; rs11982673; rs12539456; rs13221784; rs13229548; rs17537088; rs35166898; rs36121013; rs4728106; rs4731451; rs6944392; rs6949295; rs885343

# Metabolic_Enzyme_23_General_References:
1969416; 7763314; 11875049; 11875050

# Metabolic_Enzyme_23_References:
Not Available

# Metabolic_Enzyme_24_ID:
6166

# Metabolic_Enzyme_24_Name:
Adenylosuccinate synthetase isozyme 1

# Metabolic_Enzyme_24_Synonyms:
IMP--aspartate ligase 1; AdSS 1; AMPSase 1

# Metabolic_Enzyme_24_Gene_Name:
ADSSL1

# Metabolic_Enzyme_24_Protein_Sequence:
>Adenylosuccinate synthetase isozyme 1
MSGTRASNDRPPGAGGVKRGRLQQEAAATGSRVTVVLGAQWGDEGKGKVVDLLATDADII
SRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKG
LKDWEKRLIISDRAHLVFDFHQAVDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTGL
RICDLLSDFDEFSSRFKNLAHQHQSMFPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMY
EALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKA
YTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALA
LTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWE
DLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQLF

# Metabolic_Enzyme_24_Number_of_Residues:
457

# Metabolic_Enzyme_24_Molecular_Weight:
50209

# Metabolic_Enzyme_24_Theoretical_pI:
8.85

# Metabolic_Enzyme_24_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  guanyl nucleotide binding
Function:  GTP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  adenylosuccinate synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_24_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_24_Specific_Function:
Plays an important role in the de novo pathway of purine nucleotide biosynthesis

# Metabolic_Enzyme_24_Pathway:
map00230  Purine metabolism;
 map00252  Alanine and aspartate metabolism

# Metabolic_Enzyme_24_Reaction:
GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP

# Metabolic_Enzyme_24_Pfam_Domain_Function:
PF00709:Adenylsucc_synt

# Metabolic_Enzyme_24_Signals:
None

# Metabolic_Enzyme_24_Transmembrane_Regions:
None

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 6.3.4.4

# Metabolic_Enzyme_24_GenBank_ID_Protein:
21303413

# Metabolic_Enzyme_24_SwissProt_ID:
PURA1_HUMAN (Q8N142)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
ADSSL1

# Metabolic_Enzyme_24_Geneatlas_id:
ADSSL1

# Metabolic_Enzyme_24_hgnc_id:
HGNC:20093

# Metabolic_Enzyme_24_PDB_ID:
1MF1

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_24_Gene_Sequence:
>1374 bp
ATGTCGGGGACCCGAGCCTCCAACGACCGGCCCCCCGGCGCAGGCGGCGTCAAGCGGGGG
CGGCTGCAGCAGGAGGCGGCGGCGACCGGCTCCCGCGTGACGGTGGTGCTGGGCGCGCAG
TGGGGGGACGAGGGCAAAGGCAAGGTGGTGGACCTGCTGGCCACGGACGCCGACATCATC
AGCCGCTGCCAGGGGGGCAACAACGCCGGCCACACGGTGGTGGTGGATGGGAAAGAGTAC
GACTTCCACCTGCTGCCCAGCGGCATCATCAACACCAAGGCCGTGTCCTTCATTGGCAAC
GGGGTGGTCATCCACTTGCCAGGCTTGTTTGAGGAAGCAGAGAAGAATGAAAAGAAAGGC
CTGAAGGACTGGGAGAAGAGGCTCATCATCTCTGACAGAGCCCACCTTGTGTTTGATTTT
CACCAGGCTGTCGACGGACTTCAGGAAGTGCAGCGCCAGGCACAAGAGGGGAAGAATATA
GGCACCACCAAGAAGGGAATCGGACCAACCTACTCTTCCAAAGCTGCCCGGACAGGCCTC
CGCATCTGCGACCTCCTGTCAGATTTTGATGAGTTTTCCTCCAGATTCAAGAACCTGGCC
CACCAGCACCAGTCGATGTTCCCCACCCTGGAAATAGACATTGAAGGCCAACTCAAAAGG
CTCAAGGGCTTTGCTGAGCGGATCAGACCCATGGTCCGAGATGGTGTTTACTTTATGTAT
GAGGCACTCCACGGCCCCCCCAAGAAGATCCTGGTGGAGGGTGCCAACGCCGCCCTCCTC
GACATTGACTTCGGGACCTACCCCTTTGTGACTTCATCCAACTGCACCGTGGGCGGTGTG
TGCACGGGCCTGGGCATCCCCCCGCAGAACATAGGTGACGTGTATGGCGTGGTGAAAGCC
TATACCACACGTGTGGGCATCGGGGCCTTCCCCACCGAGCAGATCAACGAGATTGGAGGC
CTGCTGCAGACCCGCGGCCACGAGTGGGGAGTGACCACAGGCAGGAAGAGGCGCTGCGGC
TGGCTCGACCTGATGATTCTAAGATATGCTCACATGGTCAACGGATTCACTGCGCTGGCC
CTGACGAAGCTGGACATCCTGGACGTACTGGGTGAGGTTAAAGTCGGTGTCTCATACAAG
CTGAACGGGAAAAGGATTCCCTATTTCCCAGCTAACCAGGAGATGCTTCAGAAGGTCGAA
GTTGAGTATGAAACGCTGCCTGGGTGGAAAGCAGACACCACAGGCGCCAGGAGGTGGGAG
GACCTGCCCCCACAGGCCCAGAACTACATCCGCTTTGTGGAGAATCACGTGGGAGTCGCA
GTCAAATGGGTTGGTGTTGGCAAGTCAAGAGAGTCGATGATCCAGCTGTTTTAG

# Metabolic_Enzyme_24_GenBank_ID_Gene:
AY037159

# Metabolic_Enzyme_24_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_24_Locus:
14q32.33

# Metabolic_Enzyme_24_SNPs:
rs33958252; rs12432802; rs6644; rs10254; rs7141697; rs7142772; rs11848612; rs4983543; rs4983384; rs4247034; rs4983386; rs3803307; rs7149551; rs7149183; rs3803309; rs11844508; rs12587476; rs11848420; rs4983540; rs7160733; rs4983539; rs4983383; rs11850889; rs4983544; rs4983382; rs12883919; rs28410638; rs34672588; rs12894569; rs12887451; rs34272041; rs36104540; rs4432208; rs12885343; rs35455320; rs4587901; rs35825530; rs12881429; rs34802997; rs35614288; rs8011805; rs35023032; rs4307875; rs12885496; rs35746773; rs3803308; rs4983541; rs35590716; rs4983542; rs34420776; rs35712734; rs6576059; rs34550918; rs34673249; rs12878504; rs8004194; rs4983538; rs12886191; rs7155192; rs34936422; rs33917108; rs12896459; rs4591064; rs4983385; rs12896443; rs10623258; rs10653659; rs34022232; rs12589474; rs34879413; rs34979679; rs10150295; rs1128866; rs1128880; rs1132975; rs12433350; rs12587535; rs12587551; rs12590163; rs12590727; rs12881199; rs12892858; rs34055148; rs34251364; rs34642994; rs34877077; rs35550015; rs3803311; rs3809453; rs3809454; rs4247030; rs4247032; rs4247033; rs4351990; rs4983380; rs4983535; rs4983537; rs4983545; rs4983546; rs4983548; rs7155738; rs7156096; rs7157045; rs7161689; rs8006310; rs9672065; rs9783669

# Metabolic_Enzyme_24_General_References:
Not Available

# Metabolic_Enzyme_24_References:
Not Available

# Metabolic_Enzyme_25_ID:
5929

# Metabolic_Enzyme_25_Name:
AMP deaminase 1

# Metabolic_Enzyme_25_Synonyms:
Myoadenylate deaminase; AMP deaminase isoform M

# Metabolic_Enzyme_25_Gene_Name:
AMPD1

# Metabolic_Enzyme_25_Protein_Sequence:
>AMP deaminase 1
MPLFKLPAEEKQIDDAMRNFAEKVFASEVKDEGGRQEISPFDVDEICPISHHEMQAHIFH
LETLSTSTEARRKKRFQGRKTVNLSIPLSETSSTKLSHIDEYISSSPTYQTVPDFQRVQI
TGDYASGVTVEDFEIVCKGLYRALCIREKYMQKSFQRFPKTPSKYLRNIDGEAWVANESF
YPVFTPPVKKGEDPFRTDNLPENLGYHLKMKDGVVYVYPNEAAVSKDEPKPLPYPNLDTF
LDDMNFLLALIAQGPVKTYTHRRLKFLSSKFQVHQMLNEMDELKELKNNPHRDFYNCRKV
DTHIHAAACMNQKHLLRFIKKSYQIDADRVVYSTKEKNLTLKELFAKLKMHPYDLTVDSL
DVHAGRQTFQRFDKFNDKYNPVGASELRDLYLKTDNYINGEYFATIIKEVGADLVEAKYQ
HAEPRLSIYGRSPDEWSKLSSWFVCNRIHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLE
NIFMPVFEATINPQADPELSVFLKHITGFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPS
YTYYAYYMYANIMVLNSLRKERGMNTFLFRPHCGEAGALTHLMTAFMIADDISHGLNLKK
SPVLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEP
LMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKVKFLGDNYLEEGPAGNDIRRTNV
AQIRMAYRYETWCYELNLIAEGLKSTE

# Metabolic_Enzyme_25_Number_of_Residues:
747

# Metabolic_Enzyme_25_Molecular_Weight:
86491

# Metabolic_Enzyme_25_Theoretical_pI:
6.89

# Metabolic_Enzyme_25_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  AMP deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_25_General_Function:
Not Available

# Metabolic_Enzyme_25_Specific_Function:
AMP deaminase plays a critical role in energy metabolism

# Metabolic_Enzyme_25_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_25_Reaction:
AMP + H2O = IMP + ammonia

# Metabolic_Enzyme_25_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_25_Signals:
None

# Metabolic_Enzyme_25_Transmembrane_Regions:
None

# Metabolic_Enzyme_25_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_25_EC_Link:
EC 3.5.4.6

# Metabolic_Enzyme_25_GenBank_ID_Protein:
10864686

# Metabolic_Enzyme_25_SwissProt_ID:
AMPD1_HUMAN (P23109)

# Metabolic_Enzyme_25_swissprot_Name:
Not Available

# Metabolic_Enzyme_25_Genecard_id:
AMPD1

# Metabolic_Enzyme_25_Geneatlas_id:
AMPD1

# Metabolic_Enzyme_25_hgnc_id:
HGNC:468

# Metabolic_Enzyme_25_PDB_ID:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_25_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_25_Gene_Sequence:
>2244 bp
ATGCCTCTGTTCAAACTCCCAGCTGAAGAGAAACAAATTGATGATGCAATGCGCAACTTT
GCTGAAAAAGTGTTTGCCTCTGAAGTCAAAGATGAAGGAGGTCGTCAGGAGATTTCCCCC
TTTGATGTGGATGAGATCTGTCCGATTTCTCATCATGAGATGCAAGCACACATATTCCAT
CTGGAGACTCTGTCCACCTCCACAGAAGCCAGGAGAAAAAAGCGTTTCCAAGGACGGAAG
ACTGTTAATTTGTCCATTCCACTAAGTGAAACATCTTCCACCAAACTGTCCCACATTGAT
GAATACATTTCCTCATCTCCAACCTACCAGACCGTGCCTGATTTTCAGAGAGTGCAGATT
ACTGGTGACTATGCCTCTGGGGTTACAGTTGAAGATTTTGAAATTGTTTGCAAAGGTCTG
TATCGGGCACTATGCATACGTGAGAAATACATGCAGAAGTCGTTTCAGAGGTTCCCTAAA
ACCCCTTCCAAATACTTGCGGAACATTGATGGTGAGGCTTGGGTAGCAAATGAGAGCTTC
TATCCAGTCTTTACTCCTCCTGTGAAGAAGGGAGAGGACCCCTTCCGAACAGACAACCTT
CCTGAAAACCTGGGCTATCACCTCAAAATGAAGGACGGTGTAGTTTACGTCTATCCTAAT
GAAGCAGCAGTCAGCAAAGATGAGCCTAAGCCACTTCCTTACCCAAATCTGGACACCTTC
TTAGACGATATGAATTTTTTACTTGCTTTAATTGCTCAAGGACCTGTTAAGACCTATACC
CACCGGCGCCTGAAGTTCCTCTCCTCGAAGTTCCAGGTCCATCAGATGCTTAACGAGATG
GACGAGTTAAAGGAGCTGAAAAACAACCCCCACCGAGATTTTTATAACTGCAGGAAGGTG
GACACCCATATCCATGCAGCCGCTTGCATGAACCAGAAACATCTGCTGCGTTTTATTAAG
AAATCTTACCAAATTGATGCTGACAGAGTGGTCTATAGCACCAAAGAGAAGAATCTGACC
CTAAAGGAACTTTTTGCTAAATTAAAAATGCATCCTTATGACCTGACTGTTGATTCTCTG
GATGTTCATGCTGGACGCCAGACCTTCCAGCGTTTTGATAAGTTCAATGACAAATATAAT
CCTGTAGGAGCAAGTGAGCTACGGGACCTCTACTTGAAGACAGACAATTACATTAATGGG
GAATATTTTGCCACTATCATCAAGGAGGTAGGTGCGGACCTGGTGGAGGCCAAGTACCAG
CATGCTGAGCCCCGCCTGTCCATCTATGGCCGCAGTCCTGATGAGTGGAGCAAACTCTCC
TCCTGGTTCGTCTGCAATCGCATCCACTGCCCCAACATGACATGGATGATCCAGGTTCCC
AGGATCTATGATGTGTTCCGTTCCAAGAATTTCCTTCCACATTTTGGAAAAATGCTGGAG
AATATTTTCATGCCAGTGTTTGAGGCCACCATCAACCCCCAGGCTGACCCAGAACTCAGT
GTCTTCCTCAAGCATATCACTGGCTTTGACAGTGTGGATGATGAGTCCAAACACAGTGGC
CACATGTTCTCCTCCAAGAGTCCCAAGCCCCAGGAGTGGACATTGGAAAAGAATCCATCT
TACACTTACTATGCCTACTACATGTATGCAAACATCATGGTGCTCAACAGCCTGAGAAAG
GAACGAGGCATGAATACGTTTCTGTTCCGACCTCACTGTGGAGAAGCTGGAGCCCTCACC
CATCTCATGACAGCATTCATGATAGCAGATGATATCTCTCATGGCCTAAATTTAAAAAAG
AGTCCCGTGCTACAGTACTTGTTTTTCTTAGCCCAAATTCCCATCGCCATGTCACCACTA
AGTAACAATAGCCTATTTCTAGAGTATGCCAAAAATCCTTTTTTGGATTTCCTTCAGAAA
GGGCTAATGATCTCACTGTCTACAGATGACCCAATGCAATTCCACTTTACCAAGGAGCCC
CTAATGGAAGAATATGCTATTGCTGCACAAGTCTTCAAGCTGAGCACCTGTGATATGTGC
GAAGTGGCAAGGAACAGTGTCTTGCAGTGTGGAATTTCTCATGAGGAGAAAGTAAAGTTT
CTGGGCGACAATTACCTTGAGGAAGGCCCTGCTGGAAATGATATCCGGAGGACAAATGTA
GCCCAAATCCGCATGGCCTATCGCTATGAAACCTGGTGTTATGAACTCAATTTAATTGCT
GAGGGTCTTAAATCAACAGAATAA

# Metabolic_Enzyme_25_GenBank_ID_Gene:
M37931

# Metabolic_Enzyme_25_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_25_Locus:
1p13

# Metabolic_Enzyme_25_SNPs:
rs17602729; rs12566550; rs2268697; rs2010899; rs2268701; rs2336363; rs761755; rs2268700; rs2268699; rs2070986; rs743041; rs6679869; rs7531877; rs12407408; rs6683173; rs1884296; rs2268698; rs3789627; rs7515356; rs11585780; rs17032832; rs6678312; rs11102831; rs11589112; rs6697362; rs12132598; rs6663302; rs12038990; rs2268696; rs11588144; rs926938; rs6667218; rs34526199; rs35859650; rs2273268; rs34778674; rs34287100; rs949421; rs35197706; rs34257411; rs12096667; rs11451311; rs34245099; rs7518060; rs35468504; rs10698057; rs35746234; rs34418559; rs34741374; rs34355177; rs10601370; rs33984400; rs7541903; rs35241478; rs6656110; rs34630625; rs12036263; rs35985810; rs6685096; rs11412027; rs7543893; rs12354159; rs10645732; rs10611520; rs6701394; rs6701427; rs915955; rs737549; rs34909498; rs35027577; rs6697757; rs10776787; rs11577646; rs11587596; rs11799831; rs11801474; rs11803022; rs12564817; rs12753208; rs17032822; rs4537551; rs4839014; rs6537843; rs6695699; rs7516111

# Metabolic_Enzyme_25_General_References:
2345176; 1370861; 1631143; 11102975

# Metabolic_Enzyme_25_References:
Not Available

# Metabolic_Enzyme_26_ID:
5606

# Metabolic_Enzyme_26_Name:
Glycogen phosphorylase, liver form

# Metabolic_Enzyme_26_Synonyms:
Not Available

# Metabolic_Enzyme_26_Gene_Name:
PYGL

# Metabolic_Enzyme_26_Protein_Sequence:
>Glycogen phosphorylase, liver form
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTV
RDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEA
DDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN
TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL
PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP
KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF
QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQ
ENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV
PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPA
TDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA
ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA
YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE
SNKVNGN

# Metabolic_Enzyme_26_Number_of_Residues:
847

# Metabolic_Enzyme_26_Molecular_Weight:
97150

# Metabolic_Enzyme_26_Theoretical_pI:
7.17

# Metabolic_Enzyme_26_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
Function:  phosphorylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_26_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_26_Specific_Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

# Metabolic_Enzyme_26_Pathway:
map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_26_Reaction:
(1,4-alpha-D-glucosyl)n + phosphate = (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate

# Metabolic_Enzyme_26_Pfam_Domain_Function:
PF00343:Phosphorylase

# Metabolic_Enzyme_26_Signals:
None

# Metabolic_Enzyme_26_Transmembrane_Regions:
None

# Metabolic_Enzyme_26_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_26_EC_Link:
EC 2.4.1.1

# Metabolic_Enzyme_26_GenBank_ID_Protein:
183353

# Metabolic_Enzyme_26_SwissProt_ID:
PYGL_HUMAN (P06737)

# Metabolic_Enzyme_26_swissprot_Name:
Not Available

# Metabolic_Enzyme_26_Genecard_id:
PYGL

# Metabolic_Enzyme_26_Geneatlas_id:
PYGL

# Metabolic_Enzyme_26_hgnc_id:
HGNC:9725

# Metabolic_Enzyme_26_PDB_ID:
1L7X

# Metabolic_Enzyme_26_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_26_Subcellular_Location:
Not Available

# Metabolic_Enzyme_26_Gene_Sequence:
>2544 bp
ATGGGCGAACCGCTGACAGACCAGGAGAAGCGGCGGCAGATCAGCATCCGCGGCATCGTG
GGCGTGGAGAACGTGGCAGAGCTGAAGAAGAGTTTCAACCGGCACCTGCACTTCACGCTG
GTCAAGGACCGCAACGTGGCCACCACCCGCGACTACTACTTCGCGCTGGCGCACACGGTG
CGGGACCACCTGGTGGGGCGCTGGATCCGCACGCAGCAGCACTACTACGACAAGTGCCCC
AAGAGGGAATATTACCTCTCTCTGGAATTTTACATGGGCCGAACATTACAGAACACCATG
ATCAACCTCGGTCTGCAAAATGCCTGTGATGAGGCCATTTACCAGCTTGGATTGGATATA
GAAGAGTTAGAAGAAATTGAAGAAGATGCTGGACTTGGCAATGGTGGTCTTGGGAGACTT
GCTGCCTGCTTCTTGGATTCCATGGCAACCCTGGGACTTGCAGCCTATGGATACGGCATT
CGGTATGAATATGGGATTTTCAATCAGAAGATCCGAGATGGATGGCAGGTAGAAGAAGCA
GATGATTGGCTCAGATATGGAAACCCTTGGGAGAAGTCCCGCCCAGAATTCATGCTGCCT
GTGCACTTCTATGGAAAAGTAGAACACACCAACACCGGGACCAAGTGGATTGACACTCAA
GTGGTCCTGGCTCTGCCATATGACACCCCCGAGCCCGGCTACATGAATAACACTGTCAAC
ACCATGCGCCTCTGGTCTGCTCGGGCACCAAATGACTTTAACCTCAGAGACTTTAATGTT
GGAGACTACATTCAGGCTGTGCTGGACCGAAACCTGGCCGAGAACATCTCCCGGGTCCTC
TATCCCAATGACAATTTTTTTGAAGGGAAGGAGCTAAGATTGAAGCAGGAATACTTTGTG
GTGGCTGCAACCTTGCAAGATATCATCCGCCGTTTCAAAGCCTCCAAGTTTGGCTCCACC
CGTGGTCAAGGAACTGTGTTTGATGCCTTCCCGGATCAGGTGGCCATCCAGCTGAATGAT
ACTCACCCTCGCATCGCGATCCCTGAGCTGATGAGGATTTTTGTGGATATTGAAAAACTG
CCCTGGTCCAAGGCATGGGAGCTCAACCAGAAGACCTTCGCCTACACCAACCACACAGTG
CTCCCGGAAGCCCTGGAGCGCTGGCCCGTGGACCTGGTGGAGAAGCTGCTCCCTCGACAT
TTGGAAATCATTTATGAGATAAATCAGAAGCATTTAGATAGAATTGTGGCCTTGTTTCCT
AAAGATGTGGACCCTCTGAGAAGGATGTCTCTGATAGAAGAGGAAGGAAGCAAAAGGATC
AACATGGCCCATCTCTGCATTGTCGGTTCCCATGCTGTGAATGGCGTGGCTAAAATCCAC
TCAGACATCGTGAAGACTAAAGTATTCAAGGACTTCAGTGAGCTAGAACCTGACAAGTTT
CAGAATAAAACCAATGGGATCACTCCAAGGCGCTGGCTCCTACTCTGCAACCCAGGACTT
GCAGAGCTCATAGCAGAGAAAATTGGAGAAGACTATGTGAAAGACCTGAGCCAGCTGACG
AAGCTCCACAGCTTCCTGGGTGATGATGTCTTCCTCCGGGAACTCGCCAAGGTGAAGCAG
GAGAATAAGCTGAAGTTTTCTCAGTTCCTGGAGACGGAGTACAAAGTGAAGATCAACCCA
TCCTCCATGTTTGATGTCCAGGTGAAGAGGATACATGAGTACAAGCGACAGCTCTTGAAC
TGTCTGCATGTGATCACGATGTACAACCGCATTAAGAAAGACCCTAAGAAGTTATTCGTG
CCAAGGACAGTTATCATTGGTGGTAAAGCTGCCCCAGGATATCACATGGCCAAAATGATC
ATAAAGCTGATCACTTCAGTGGCAGATGTGGTGAACAATGACCCTATGGTTGGAAGCAAG
TTGAAAGTCATCTTCTTGGAGAACTACAGAGTATCTCTTGCTGAAAAAGTCATTCCAGCC
ACAGATCTGTCAGAGCAGATTTCCACTGCAGGCACCGAAGCCTCGGGGACAGGCAATATG
AAGTTCATGCTAAATGGGGCCCTAACTATCGGGACCATGGATGGGGCCAATGTGGAAATG
GCAGAAGAAGCTGGGGAAGAGAACCTGTTCATCTTTGGCATGAGCATAGATGATGTGGCT
GCTTTGGACAAGAAAGGGTACGAGGCAAAAGAATACTATGAGGCACTTCCAGAGCTGAAG
CTGGTCATTGATCAAATTGACAATGGCTTTTTTTCTCCCAAGCAGCCTGACCTCTTCAAA
GATATCATCAACATGCTATTTTATCATGACAGGTTTAAAGTCTTTGCAGACTACGAAGCC
TATGTCAAGTGTCAAGATAAAGTGAGTCAGCTGTACATGAATCCAAAGGCCTGGAACACA
ATGGTACTCAAAAACATAGCTGCCTCGGGGAAATTCTCCAGTGACCGAACAATTAAAGAA
TATGCCCAAAACATCTGGAACGTGGAACCTTCAGATCTAAAGATTTCTCTATCCAATGAA
TCTAACAAAGTCAATGGAAATTGA

# Metabolic_Enzyme_26_GenBank_ID_Gene:
M14636

# Metabolic_Enzyme_26_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_26_Locus:
14q21-q22

# Metabolic_Enzyme_26_SNPs:
rs946616; rs2228499; rs35831273; rs34313873; rs2275465; rs17123244; rs1042193; rs2027342; rs2277456; rs1959527; rs2356729; rs1890706; rs1953875; rs946618; rs946617; rs1890705; rs883699; rs1890707; rs8004768; rs10143053; rs11157783; rs2275464; rs6572712; rs7160537; rs2075646; rs6572710; rs10132049; rs3825542; rs11852047; rs3783275; rs11846565; rs8021270; rs11846180; rs8022952; rs2027341; rs1953872; rs10149867; rs11851644; rs3783273; rs3825541; rs2356535; rs3783274; rs8004788; rs11851482; rs17123189; rs11851115; rs8014291; rs2275466; rs7142143; rs12432519; rs11845307; rs7149936; rs17123178; rs1953873; rs10138493; rs10140858; rs3818871; rs8005400; rs17123235; rs11844515; rs11850411; rs3783276; rs7154048; rs8019788; rs12436081; rs12717412; rs10146041; rs8003312; rs8003460; rs882860; rs8022363; rs17123173; rs9635167; rs6572711; rs17123125; rs10142003; rs17123232; rs8005931; rs4901066; rs11845548; rs11623430; rs12878997; rs8008832; rs17123223; rs8006455; rs8019957; rs17123216; rs17123180; rs8020787; rs17123242; rs3783277; rs8019817; rs11849348; rs11851406; rs8009460; rs8019779; rs11846533; rs11850468; rs10130689; rs8020100; rs9635221; rs12887698; rs2297890; rs7159436; rs3759524; rs2297891; rs8005560; rs7159221; rs1126549; rs35026927; rs34096980; rs11541446; rs1042210; rs1042195; rs17721570; rs35110875; rs1042191; rs11356035; rs8018727; rs10539449; rs11420723; rs35650221; rs28419360; rs34660650; rs34764341; rs35154208; rs5808582; rs33962723; rs7157107; rs36014565; rs8021856; rs3837582; rs10140029; rs34040095; rs28584430; rs10146475; rs5808583; rs34267914; rs35765728; rs4540982; rs11849168; rs12888774; rs12881770; rs12882746; rs8006359; rs9788547; rs17123214; rs8009028; rs34052455; rs35565564; rs35049468; rs35657235; rs17123129; rs34648049; rs3783278; rs5808581; rs10145332; rs35116945; rs17123212; rs28497027; rs11308384; rs4027576; rs12882737; rs35955629; rs35236069; rs34707370; rs11351672; rs12887874; rs35638781; rs17123170; rs11414268; rs12881559; rs10674203; rs34456437; rs10133328; rs1890701; rs12882740; rs41317304; rs33993827; rs11846857; rs8005878; rs35069435; rs35098001; rs7141901; rs3082637; rs35620941; rs35195741; rs8016466; rs17123239; rs12882739; rs12879826; rs4898677; rs28540603; rs34592047; rs34351109; rs28407049; rs28707425; rs12880288; rs28759343; rs1005689; rs1042266; rs11157780; rs11157781; rs11157782; rs11847031; rs11847533; rs11850729; rs11850781; rs12431674; rs12431737; rs12434792; rs12589201; rs12589665; rs12880129; rs12889552; rs12891106; rs1538615; rs17123097; rs17123103; rs17123116; rs1890700; rs1890704; rs2075643; rs2075644; rs2075645; rs2185303; rs2356730; rs28564871; rs34204001; rs34240348; rs34800262; rs35501326; rs3759519; rs3759520; rs3759521; rs4901064; rs4901065; rs4901067; rs7154732; rs7159068; rs885375

# Metabolic_Enzyme_26_General_References:
2877458; 9536091; 9529348; 3509980; 10980448; 10949035; 12204691

# Metabolic_Enzyme_26_References:
Not Available

# Metabolic_Enzyme_27_ID:
5668

# Metabolic_Enzyme_27_Name:
Inosine triphosphate pyrophosphatase

# Metabolic_Enzyme_27_Synonyms:
ITPase; Inosine triphosphatase; Putative oncogene protein hlc14-06-p

# Metabolic_Enzyme_27_Gene_Name:
ITPA

# Metabolic_Enzyme_27_Protein_Sequence:
>Inosine triphosphate pyrophosphatase
MAASLVGKKIVFVTGNAKKLEEVVQILGDKFPCTLVAQKIDLPEYQGEPDEISIQKCQEA
VRQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLAGFEDKSAYALCTFAL
STGDPSQPVRLFRGRTSGRIVAPRGCQDFGWDPCFQPDGYEQTYAEMPKAEKNAVSHRFR
ALLELQEYFGSLAA

# Metabolic_Enzyme_27_Number_of_Residues:
194

# Metabolic_Enzyme_27_Molecular_Weight:
21446

# Metabolic_Enzyme_27_Theoretical_pI:
5.34

# Metabolic_Enzyme_27_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_27_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_27_Specific_Function:
Hydrolyzes ITP and dITP to their respective monophosphate derivatives. Xanthosine 5'-triphosphate (XTP) is also a potential substrate. May be the major enzyme responsible for regulating ITP concentration in cells

# Metabolic_Enzyme_27_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_27_Reaction:
A nucleoside triphosphate + H2O = a nucleotide + diphosphate

# Metabolic_Enzyme_27_Pfam_Domain_Function:
PF01725:Ham1p_like

# Metabolic_Enzyme_27_Signals:
None

# Metabolic_Enzyme_27_Transmembrane_Regions:
None

# Metabolic_Enzyme_27_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_27_EC_Link:
EC 3.6.1.19

# Metabolic_Enzyme_27_GenBank_ID_Protein:
13398328

# Metabolic_Enzyme_27_SwissProt_ID:
ITPA_HUMAN (Q9BY32)

# Metabolic_Enzyme_27_swissprot_Name:
Not Available

# Metabolic_Enzyme_27_Genecard_id:
ITPA

# Metabolic_Enzyme_27_Geneatlas_id:
ITPA

# Metabolic_Enzyme_27_hgnc_id:
HGNC:6176

# Metabolic_Enzyme_27_PDB_ID:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_27_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_27_Gene_Sequence:
>585 bp
ATGGCGGCCTCATTGGTGGGGAAGAAGATCGTGTTTGTAACGGGGAACGCCAAGAAGCTG
GAGGAGGTCGTTCAGATTCTAGGAGATAAGTTTCCACGCACTTTGGTGGCACAGAAAATT
GACCTGCCGGAGTACCAGGGGGAGCCGGATGAGATTTCCATACAGAAATGTCAGGAGGCA
GTTCGCCAGGTACAGGGGCCCGTGCTGGTTGAGGACACTTGTCTGTGCTTCAATGCCCTT
GGAGGGCTCCCCGGCCCCTACATAAAGTGGTTTCTGGAGAAGTTAAAGCCTGAAGGTCTC
CACCAGCTCCTGGCCGGGTTCGAGGACAAGTCAGCCTATGCGCTCTGCACGTTTGCACTC
AGCACCGGGGACCCAAGCCAGCCCGTGCGCCTGTTCAGGGGCCGGACCTCGGGCCGGATC
GTGGCACCCAGAGGCTGCCAGGACTTTGGCTGGGACCCCTGCTTTCAGCCTGATGGATAT
GAGCAGACGTACGCAGAGATGCCTAAGGCGGAGAAGAACGCTGTCTCCCATCGCTTCCGG
GCCCTGCTGGAGCTGCAGGAGTACTTTGGCAGTTTGGCAGCTTGA

# Metabolic_Enzyme_27_GenBank_ID_Gene:
AF219116

# Metabolic_Enzyme_27_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_27_Locus:
20p

# Metabolic_Enzyme_27_SNPs:
rs41320251; rs9101; rs8362; rs13830; rs1043688; rs6051646; rs4815576; rs6139034; rs6037506; rs6107257; rs2236206; rs6084307; rs6084305; rs11087571; rs6037502; rs6139033; rs6084304; rs6139036; rs6037501; rs6107258; rs6139035; rs8115328; rs6084301; rs6084308; rs7262711; rs2422863; rs6084306; rs2422862; rs11087570; rs6084303; rs6051648; rs4813632; rs6037504; rs11906193; rs12625773; rs4815577; rs6084302; rs8114386; rs2422860; rs6051650; rs7270101; rs6037503; rs6076494; rs6051644; rs6076491; rs6139031; rs6037500; rs34982958; rs1043959; rs11480889; rs8122216; rs35820452; rs35991941; rs35671839; rs6115816; rs6076493; rs11905115; rs11473134; rs6051653; rs35249381; rs13040402; rs33944702; rs6076495; rs6115819; rs7270134; rs6084300; rs35002933; rs28479679; rs6115815; rs6133021; rs10598340; rs6051647; rs6076496; rs35141053; rs6115814; rs6115818; rs6139032; rs11481198; rs2422861; rs33961294; rs34376287; rs12480483; rs6115817; rs34475210; rs35568595; rs4447662; rs34868586; rs6084309; rs10537787; rs11471713; rs11469873; rs6051649; rs6076492; rs8113964; rs8116264; rs9680022; rs6037505; rs6051651; rs35127071; rs11479168; rs13043233; rs34929648; rs6051645; rs35045261; rs4510299; rs10048856; rs11697114; rs11697186; rs11699145; rs11907085; rs2144771; rs2295553; rs34224785; rs3810559; rs3810560; rs4630837; rs6051639; rs6051643; rs6051654; rs6051655; rs6051657; rs6051658; rs6084312; rs6115821; rs6139039; rs7262083; rs7262506; rs731282; rs7344681; rs8115151; rs8117254

# Metabolic_Enzyme_27_General_References:
11278832; 11780052; 12384777; 12436200

# Metabolic_Enzyme_27_References:
Not Available

End of HMDB00175

Beginning of HMDB00176
# Accession_No:
HMDB00176

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-13 12:09:12

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Maleic acid

# Description:
Maleic acid is an industrial raw material for the production of glyoxylic acid by ozonolysis. Maleic acid is an organic compound which is a dicarboxylic acid (molecule with two carboxyl groups). The molecule consists of an ethylene group flanked by two carboxylic acid groups. Maleic acid is the cis isomer of butenedioic acid, whereas fumaric acid is the trans isomer. The cis isomer is the less stable one of the two; the difference in heat of combustion is 22.7 kJ/mol. The physical properties of maleic acid are very different from that of fumaric acid. Maleic acid is soluble in water whereas fumaric acid is not and the melting point of maleic acid (130 - 131 degree centigrade) is also much lower than that of fumaric acid (287 degree centigrade). Both properties of maleic acid can be explained on account of the intramolecular hydrogen bonding that takes place at the expense of intermolecular interactions. Maleic acid is converted into maleic anhydride by dehydration, to malic acid by hydration, and to succinic acid by hydrogenation. It reacts with thionyl chloride or phosphorus pentachloride to give the maleic acid chloride (it is not possible to isolate the mono acid chloride). Maleic acid is a reactant in many Diels-Alder reactions.

# Synonyms:
(2Z)-2-Butenedioic acid; (2Z)-Butene-2-dioic acid; (2Z)-but-2-enedioic acid; (Z)-2-Butenedioic acid; (z)-butenedioic acid; 2-Butenedioic acid; Cis-butenedioic acid; H2male; Kyselina maleinova; MAE; Maleate; Maleic acid; Maleic acid [NA2215]; Maleinic acid; Malenic acid; Malezid CM; Scotchbond multipurpose etchant; Toxilic acid; cis-1,2-Ethylenedicarboxylic acid; cis-2-Butenedioic acid; cis-but-2-enedioic acid

# Chemical_IUPAC_Name:
but-2-enedioic acid

# Chemical_Formula:
C4H4O4

# Chemical_Structure:
tbl_chemical:::HMDB00176_ZOOM.png:::11928323545646188

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00176_THUMB.png:::119283235298034189

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
alkene; carboxylic acid

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
116.01096

# Molecular_Weight_Avg:
116.07216

# Smiles_String_isomeric:
OC(=O)C=C/C(O)=O

# Smiles_String_canonical:
OC(=O)C=CC(O)=O

# KEGG_Compound_ID:
C01384

# BioCyc_ID:
Not Available

# PubChem_CID:
444266

# PubChem_SID:
10299513; 10354664; 10503811; 14747527; 17389671; 197258; 3133743; 3754587; 4579; 584104; 587072; 589605; 611192; 7853008; 7888747; 8145595; 819267; 819380; 819516; 819542; 819544; 819547; 819549; 819552; 821182; 823051; 824857; 825151; 830933; 830935; 830937; 834177; 834550; 841400; 86933

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Maleic acid

# METLIN_ID:
4198

# Ref_ID:
12859262; 1495787; 16797943; 15835174; 15924314; 9835798; 8087979; 2759844; 9872612; 12895502; 10965422; 7075967; 10024972; 10522050; 10635272; 16778650; 16043230; 7905382; 12450709; 12009699

# ChEBI_ID:
18300

# CAS_Registry_Number:
110-16-7

# InChI:
InChI=1/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1-

# Synthesis_Reference:
Hydrogenation of unsaturated dicarboxylic acids by dicarbonylbis(h5-cyclopentadienyl)titanium(II) and molecular structure of (m-acetylenedicarboxylato)bis[bis(h5-methylcyclopentadienyl)titanium(III)].     Corbin, David R.; Atwood, J. L.; Stucky, Galen D.

# Melting_Point:
130.5 oC

# Melting_Point_predicted:
28.8 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
441 mg/mL at 25 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
24.1 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-0.48 [SANGSTER (1994)]

# LogP_predicted:
-0.4 [Predicted by PubChem via XLOGP]; 0.21 [Predicted by ALOGPS]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::1166040796.pdf:::255635823979345>>>tbl_chemical:::1166040791.pdf:::182318577056336>>>tbl_chemical:::1166040868.html:::159680376292087

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::1166040881.mol:::147591735849907

# SDF_File_[Text]:
tbl_chemical:::HMDB00176.sdf:::119283235002146914

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00176.pdb:::119283235161696068

# PDB_ID:
1D4E

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041010_P00_02_HW_1DP_PRESAT_expanded_2.gif:::114168246285972638

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041010_P00_02_HW_1DP_presat.zip:::1177710584594648050

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041010_P00_02_HW_1DP_Assigned.png:::114667758525338941

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041010_P00_02_HW_2DHSQC_609.png:::114781413853499201

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041010_P00_02_HW_2DHSQC_609.zip:::11478141385403284

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041010_P00_02_HW_2DHSQC_609_Assigned.png:::114781413903457202

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Maleic acid.gif:::1132732118656493417

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00176_peaks.txt:::1156309597941605600

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Maleic acid_C.gif:::1132737712096950439

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00176_peaks.txt:::1156310787402728640

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00176L.png:::117555262400027470; Medium Energy:tbl_ms:::HMDB00176M.png:::117555267774069640; High Energy:tbl_ms:::HMDB00176H.png:::117555271384624567

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000212.png:::116890831654620261

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000212.txt:::116890831690636900

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Fibroblasts; Muscle; Neurons; Pancreas; Platelet; Prostate; Spleen

# deuterated:
No

# Biofluid_Location:
Amniotic Fluid; Blood; Urine

# Concentration_[Normal]:
Urine	10.4	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	8087979
Urine	10.7	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	8087979
Urine	0.7	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	0.1	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	0.5	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	8087979
Urine	10.7	umol/mmol_creatinine	Adult:>18_yrs_old	N/A	Normal	8087979
Urine	0.1	umol/mmol_creatinine	N/A	N/A	Normal	8087979
Blood	>10.0	umol/L	Adult:>18_yrs_old	Both	Normal	12009699


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Glaucoma; Ocular Hypertension; Osteoporosis

# Pathway_Names:
Purine metabolism;Alanine and aspartate metabolism;Oxidative phosphorylation;Reductive carboxylate cycle (CO2 fixation)

# Pathway_Images:
Purine_Synthesis.jpg;Aspartate_and_Alanine_metabolism.jpg;;

# KEGG_Images:
map00230;map00252;map00190;map00720

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;Aspartate_and_Alanine_metabolism_Graph.jpg;;

# Pathway_SBMLs:
Purine_Synthesis.xml;Aspartate_and_Alanine_metabolism.xml;;

# Metabolic_Enzyme_1_ID:
5485

# Metabolic_Enzyme_1_Name:
Dopamine beta-hydroxylase precursor

# Metabolic_Enzyme_1_Synonyms:
Dopamine beta- monooxygenase

# Metabolic_Enzyme_1_Gene_Name:
DBH

# Metabolic_Enzyme_1_Protein_Sequence:
>Dopamine betahydroxylase precursor
MREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYHIPLDPEGSLELSWNVSYTQEAIHF
QLLVRRLKAG
VLFGMSDRGELENADLVVLWTDGDTAYFADAWSDQKGQIHLDPQQDYQL
LQVQRTPEGLTLLFKRPFGTC
DPKDYLIEDGTVHLVYGILEEPFRSLEAINGSGLQMGL
QRVQLLKPNIPEPELPSDACTMEVQAPNIQIP
SQETTYWCYIKELPKGFSRHHIIKYEP
IVTKGNEALVHHMEVFQCAPEMDSVPHFSGPCDSKMKPDRLNY
CRHVLAAWALGAKAFY
YPEEAGLAFGGPGSSRYLRLEVHYHNPLVIEGRNDSSGIRLYYTAKLRRFNAGI
MELGL
VYTPVMAIPPRETAFILTGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKVVTVLVRDGR
EWEIV
NQDNHYSPHFQEIRMLKKVVSVHPGDVLITSCTYNTEDRELATVGGFGILEEMC
VNYVHYYPQTQLELCK
SAVDAGFLQKYFHLINRFNNEDVCTCPQASVSQQFTSVPWNSF
NRDVLKALYSFAPISMHCNKSSAVRFQ
GEWNLQPLPKVISTLEEPTPQCPTSQGRSPAG
PTVVSIGGGKG

# Metabolic_Enzyme_1_Number_of_Residues:
603

# Metabolic_Enzyme_1_Molecular_Weight:
67614

# Metabolic_Enzyme_1_Theoretical_pI:
6.31

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
Function:  dopamine beta-monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  catecholamine metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  histidine family amino acid metabolism
Process:  histidine metabolism
Process:  histidine catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Conversion of dopamine to noradrenaline

# Metabolic_Enzyme_1_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_1_Reaction:
3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF03712:Cu2_monoox_C;
PF01082:Cu2_monooxygen;
PF03351:DOMON

# Metabolic_Enzyme_1_Signals:
1-25

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.14.17.1

# Metabolic_Enzyme_1_GenBank_ID_Protein:
30474

# Metabolic_Enzyme_1_SwissProt_ID:
DOPO_HUMAN (P09172)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
DBH

# Metabolic_Enzyme_1_Geneatlas_id:
DBH

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2689

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasmic vesicle; secretory vesicle; chromaffin granule. Cytoplasmic vesicle; secretory vesicle; chromaffin granule; chromaffin granule membrane. Note=Exists both in a soluble form (in chromaffin granules) and as membrane bound (the membrane bound form is anchored by an uncleaved signal peptide)

# Metabolic_Enzyme_1_Gene_Sequence:
>1812 bp

ATGCGGGAGGCAGCCTTCATGTACAGCACAGCAGTGGCCATCTTCCTGGTCATCCTGGT
GGCCGCACTGC
AGGGCTCGGCTCCCCGTGAGAGCCCCCTCCCCTATCACATCCCCCTGG
ACCCGGAGGGGTCCCTGGAGCT
CTCATGGAATGTCAGCTACACCCAGGAGGCCATCCAT
TTCCAGCTCCTGGTGCGGAGGCTCAAGGCTGGC
GTCCTGTTTGGGATGTCCGACCGTGG
CGAGCTTGAGAACGCAGATCTCGTGGTGCTCTGGACCGATGGGG
ACACTGCCTATTTTG
CGGACGCCTGGAGTGACCAGAAGGGGCAGATCCACCTGGATCCCCAGCAGGACTA
CCAG
CTGCTGCAGGTGCAGAGGACCCCAGAAGGCCTGACCCTGCTTTTCAAGAGGCCCTTTGGC
ACCTGC
GACCCCAAGGATTACCTCATTGAAGACGGCACTGTCCACTTGGTCTACGGGAT
CCTGGAGGAGCCGTTCC
GGTCACTGGAGGCCATCAACGGCTCGGGCCTGCAGATGGGGC
TGCAGAGGGTGCAGCTCCTGAAGCCCAA
TATCCCCGAACCGGAGTTGCCCTCAGACGCG
TGCACCATGGAGGTCCAAGCTCCCAATATCCAGATCCCC
AGCCAGGAGACCACGTACTG
GTGCTACATTAAGGAGCTTCCAAAGGGCTTCTCTCGGCACCACATTATCA
AGTACGAGC
CCATCGTCACCAAGGGCAATGAGGCCCTTGTCCACCACATGGAAGTCTTCCAGTGCGCCC
C
CGAGATGGACAGCGTCCCCCACTTCAGCGGGCCCTGCGACTCCAAGATGAAACCCGAC
CGCCTCAACTAC
TGCCGCCACGTGCTGGCCGCCTGGGCCCTGGGTGCCAAGGCATTTTA
CTACCCAGAGGAAGCCGGCCTTG
CCTTCGGGGGTCCAGGGTCCTCCAGATATCTCCGCC
TGGAAGTTCACTACCACAACCCACTGGTGATAGA
AGGACGAAACGACTCCTCAGGCATC
CGCTTGTACTACACAGCCAAGCTGCGGCGCTTCAACGCGGGGATC
ATGGAGCTGGGACT
GGTGTACACGCCAGTGATGGCCATTCCACCACGGGAGACCGCCTTCATCCTCACTG
GCT
ACTGCACGGACAAGTGCACCCAGCTGGCACTGCCTCCCTCCGGGATCCACATCTTCGCCT
CTCAGCT
CCACACACACCTGACTGGGAGAAAGGTGGTCACAGTGCTGGTCCGGGACGGC
CGGGAGTGGGAGATCGTG
AACCAGGACAATCACTACAGCCCTCACTTCCAGGAGATCCG
CATGTTGAAGAAGGTCGTGTCGGTCCATC
CGGGAGATGTGCTCATCACCTCCTGCACGT
ACAACACGGAAGACCGGGAGCTGGCCACAGTGGGGGGCTT
CGGGATCCTGGAGGAGATG
TGTGTCAACTACGTGCACTACTACCCCCAGACGCAGCTGGAGCTCTGCAAG
ACGGCTGT
GGACGCCGGCTTCCTGCAGAAGTACTTCCACCTCATCAACAGGTTCAACAACGAGGATGT
CT
GCACCTGCCCTCAGGCGTCCGTGTCTCAGCAGTTCACCTCTGTTCCCTGGAACTCCT
TCAACCGCGACGT
ACTGAAGGCCCTGTACAGCTTCGCGCCCATCTCCATGCACTGCAAC
AAGTCCTCAGCCGTCCGCTTCCAG
GGTGAATGGAACCTGCAGCCCCTGCCCAAGGTCAT
CTCCACACTGGAAGAGCCCACCCCACAGTGCCCCA
CCAGCCAGGGCCGAAGCCCTGCTG
GCCCCACCGTTGTCAGCATTGGTGGGGGCAAAGGCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X13255

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_1_Locus:
9q34

# Metabolic_Enzyme_1_SNPs:
rs5324; rs5320; rs4531; rs5325; rs1108580; rs77905; rs5322; rs5318; rs2519154; rs2797849; rs1541333; rs6479643; rs1611126; rs1108581; rs7035577; rs2797853; rs7876027; rs1611122; rs1611130; rs1611124; rs3025399; rs12343735; rs3025405; rs2797852; rs1541332; rs3025383; rs2519143; rs1611120; rs1611128; rs1611123; rs1611119; rs7862391; rs3025411; rs3025395; rs9657707; rs3025391; rs2519151; rs3025382; rs2007153; rs2797855; rs2283123; rs2283124; rs3025388; rs2519155; rs2873804; rs1548364; rs80858; rs1611125; rs2797851; rs739398; rs3025390; rs3025410; rs129911; rs10993947; rs2283122; rs129913; rs3025413; rs1548367; rs10121827; rs3025401; rs12003344; rs3025387; rs3025403; rs2519153; rs2797854; rs7870239; rs3025393; rs129910; rs7864658; rs2005663; rs3025404; rs3025406; rs1611127; rs2797850; rs3025408; rs3739885; rs129908; rs2519157; rs129909; rs1611118; rs2519152; rs13284520; rs3025392; rs2519144; rs1611114; rs1611115; rs129883; rs129915; rs12002610; rs3025379; rs1611116; rs13306301; rs41316996; rs2797848; rs5319; rs5323; rs3025380; rs13306306; rs5321; rs13306303; rs17851478; rs35465867; rs3025400; rs35043556; rs3739886; rs35067824; rs3025381; rs28419319; rs3025415; rs1548365; rs28481752; rs5901024; rs3081166; rs13306307; rs3025385; rs1611129; rs35246072; rs12001868; rs2519156; rs35528158; rs11278217; rs11283016; rs13293282; rs3025428; rs34469151; rs13306302; rs3025430; rs35806215; rs35682711; rs28662126; rs7032535; rs34932746; rs12003763; rs3025416; rs3025427; rs3025384; rs3025426; rs1548366; rs3025389; rs4333676; rs3025398; rs28738882; rs13306308; rs1548368; rs129912; rs3025386; rs7027680; rs28698922; rs1611121; rs35688529; rs12005180; rs3025396; rs5901023; rs3025414; rs28534474; rs3025407; rs13306305; rs3025402; rs3025429; rs3025409; rs35808071; rs3025394; rs3025412; rs34553440; rs34242880; rs13298385; rs34701710; rs34498190; rs3025377; rs1611117; rs12684659; rs3025433; rs10993904; rs3025432; rs13285918; rs3025378; rs2797847; rs1076150; rs1076153; rs10993885; rs10993886; rs10993948; rs10993949; rs10993950; rs12337651; rs129882; rs129884; rs129885; rs129888; rs129914; rs129916; rs129917; rs129918; rs129919; rs129921; rs129922; rs129923; rs129924; rs129925; rs129926; rs129928; rs129929; rs129930; rs129931; rs17150766; rs1989787; rs2073833; rs2073835; rs2073836; rs2073837; rs2097628; rs2519145; rs2519147; rs2519148; rs2519149; rs2519764; rs2519765; rs3025369; rs3025370; rs3025371; rs3025372; rs3025373; rs3025374; rs3025375; rs3025376; rs3025417; rs3025418; rs3025419; rs3025421; rs3025422; rs3025423; rs3025424; rs3025425; rs3025431; rs3025434; rs3025435; rs3025436; rs3025437; rs3025438; rs3025439; rs3025440; rs3025441; rs3025443; rs6271; rs7043939; rs732833; rs7851898; rs7859358; rs9409875

# Metabolic_Enzyme_1_General_References:
2922261; 3443096; 8546710; 10490716; 10391209; 10391210; 11857564

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5857

# Metabolic_Enzyme_2_Name:
Adenylosuccinate lyase

# Metabolic_Enzyme_2_Synonyms:
Adenylosuccinase; ASL; ASASE

# Metabolic_Enzyme_2_Gene_Name:
ADSL

# Metabolic_Enzyme_2_Protein_Sequence:
>Adenylosuccinate lyase
MAAGGDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDE
QIQEMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTD
LIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLC
MDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITG
QTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMR
SERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISE
GLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGD
NDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKA
ELCL

# Metabolic_Enzyme_2_Number_of_Residues:
484

# Metabolic_Enzyme_2_Molecular_Weight:
54890

# Metabolic_Enzyme_2_Theoretical_pI:
7.12

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  lyase activity
Function:  carbon-nitrogen lyase activity
Function:  amidine-lyase activity
Function:  adenylosuccinate lyase activity
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine ribonucleotide biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
6-N-(1,2-dicarboxyethyl)AMP = fumarate + AMP

# Metabolic_Enzyme_2_Pathway:
map00230  Purine metabolism;
 map00252  Alanine and aspartate metabolism

# Metabolic_Enzyme_2_Reaction:
(1) N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP; (2) (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00206:Lyase_1

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 4.3.2.2

# Metabolic_Enzyme_2_GenBank_ID_Protein:
28904

# Metabolic_Enzyme_2_SwissProt_ID:
PUR8_HUMAN (P30566)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ADSL

# Metabolic_Enzyme_2_Geneatlas_id:
ADSL

# Metabolic_Enzyme_2_hgnc_id:
HGNC:291

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>1455 bp
ATGGCGGCTGGAGGCGATCATGGTTCGCCCGACAGCTACCGCTCACCTCTTGCCTCCCGC
TATGCCAGCCCGGAGATGTGCTTCGTGTTTAGCGACAGGTATAAATTCCGGACATGGCGG
CAGCTGTGGCTGTGGCTGGCGGAGGCCGAGCAGACATTGGGTTTGCCTATCACAGATGAA
CAAATCCAGGAGATGAAATCAAACCTGGAGAACATAGACTTCAAGATGGCAGCTGAGGAA
GAGAAACGTTTACGACATGATGTGATGGCTCACGTGCACACATTTGGCCACTGCTGTCCA
AAAGCTGCAGGCATTATTCACCTTGGTGCTACTTCTTGCTATGTTGGAGACAATACTGAC
TTGATTATTCTTAGAAATGCACTTGACCTGCTTTTGCCAAAGCTTGCCAGAGTGATCTCT
CGGCTTGCCGACTTTGCTAAGGAACGAGCCAGTCTACCCACATTAGGTTTCACACATTTC
CAGCCTGCACAGCTGACCACAGTTGGGAAACGTTGCTGTCTTTGGATTCAGGATCTTTGC
ATGGATCTCCAGAACTTGAAGCGTGTCCGAGATGACCTGCGCTTCCGGGGAGTAAAGGGT
ACCACTGGCACTCAGGCCAGTTTCCTGCAGCTCTTTGAGGGAGATGACCATAAGGTAGAG
CAGCTTGACAAGATGGTGACAGAAAAGGCAGGATTTAAGAGAGCTTTCATCATCACAGGG
CAGACATATACACGAAAAGTGGATATTGAAGTACTGTCTGTGCTGGCTAGCTTGGGGGCA
TCAGTGCACAAGATTTGCACCGACATACGCCTCCTGGCAAACCTCAAGGAGATGGAGGAA
CCCTTTGAAAAACAGCAGATTGGCTCAAGTGCGATGCCATATAAGCGGAATCCCATGCGT
TCAGAACGTTGCTGCAGTCTTGCCCGCCACCTGATGACCCTTGTCATGGACCCGCTACAG
ACAGCATCTGTCCAGTGGTTTGAACGCACACTGGATGATAGTGCCAACCGACGGATCTGT
TTGGCCGAGGCATTTCTTACCGCAGATACTATATTGAATACGCTGCAGAACATTTCTGAA
GGATTGGTCGTGTACCCCAAAGTAATTGAACGGCGCATTCGGCAAGAGCTGCCTTTCATG
GCCACAGAGAACATCATCATGGCCATGGTCAAAGCTGGAGGTAGCCGCCAGGATTGCCAT
GAGAAAATCAGAGTGCTTTCTCAGCAGGCAGCTTCTGTGGTTAAGCAGGAAGGGGGTGAC
AATGACCTCATAGAGCGTATCCAGGTTGATGCCTACTTCAGTCCCATTCACTCCCAGTTG
GATCATTTACTGGATCCTTCTTCTTTCACTGGTCGTGCCTCCCAGCAGGTGCAGAGATTC
TTAGAAGAGGAGGTGTATCCCCTGTTAAAACCATATGAAAGCGTGATGAAGGTGAAAGCA
GAATTATGTCTGTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X65867

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_2_Locus:
22q13.1|22q13.2

# Metabolic_Enzyme_2_SNPs:
rs2068470; rs3788578; rs3788579; rs3788577; rs9611321; rs8135371; rs7291418; rs17001846; rs10854729; rs11913275; rs2280790; rs2075764; rs12160297; rs5757922; rs17001863; rs17001848; rs17001857; rs4321458; rs2006965; rs909669; rs12484610; rs5757921; rs8192461; rs11089991; rs8192457; rs34396910; rs8192454; rs2735668; rs11703124; rs8192453; rs8192458; rs2743718; rs17001854; rs5995848; rs2743725; rs2735660; rs2735669; rs34476033; rs2735672; rs4820411; rs2743716; rs6001886; rs35043528; rs35572733; rs5995847; rs2743723; rs2735665; rs10427931; rs11089990; rs2743721; rs12170384; rs2743728; rs2743719; rs8192455; rs2735667; rs8192460; rs1882824; rs5757924; rs36099663; rs2735663; rs2735673; rs2743717; rs10427911; rs28699192; rs2743726; rs3830737; rs2743724; rs7285719; rs6001887; rs8192452; rs28642715; rs9611322; rs5750935; rs2735664; rs2735666; rs8192459; rs11431892; rs9611323; rs1882823; rs35553188; rs8142978; rs2743729; rs2743722; rs5757923; rs2735661; rs8192456; rs35401769; rs2743727; rs17001850; rs2743720; rs35128658; rs3044501; rs2743731; rs742139; rs2006961; rs909205; rs5995846; rs9607708; rs5757920; rs2743714; rs751367; rs5995845; rs5757918; rs16985898; rs9611320; rs2743732; rs35992774; rs909204; rs11320845; rs2743730; rs2743715; rs10650685; rs5757919; rs2743713; rs12484697; rs4619722; rs5995844; rs6001883; rs6001888; rs9611310; rs9611311; rs9611312; rs9611314; rs9611316; rs9611318; rs9623170

# Metabolic_Enzyme_2_General_References:
10888601; 10591208; 1302001; 9545543; 10090474; 10958654; 12368987

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5425

# Metabolic_Enzyme_3_Name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor

# Metabolic_Enzyme_3_Synonyms:
Ip; Iron-sulfur subunit of complex II

# Metabolic_Enzyme_3_Gene_Name:
SDHB

# Metabolic_Enzyme_3_Protein_Sequence:
>Succinate dehydrogenase ubiquinone ironsulfur subunit, mitochondrial precursor
MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQT
YEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTN
LNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKL
DGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSL
YRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV

# Metabolic_Enzyme_3_Number_of_Residues:
280

# Metabolic_Enzyme_3_Molecular_Weight:
31630

# Metabolic_Enzyme_3_Theoretical_pI:
8.92

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  transporter activity
Function:  electron transporter activity
 ||
>>>
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
Succinate + ubiquinone = fumarate + ubiquinol

# Metabolic_Enzyme_3_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00190  Oxidative phosphorylation

# Metabolic_Enzyme_3_Reaction:
succinate + ubiquinone = fumarate + ubiquinol

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00111:Fer2

# Metabolic_Enzyme_3_Signals:
1-15

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.3.5.1

# Metabolic_Enzyme_3_GenBank_ID_Protein:
665925

# Metabolic_Enzyme_3_SwissProt_ID:
DHSB_HUMAN (P21912)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
SDHB

# Metabolic_Enzyme_3_Geneatlas_id:
SDHB

# Metabolic_Enzyme_3_hgnc_id:
HGNC:10681

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane

# Metabolic_Enzyme_3_Gene_Sequence:
>843 bp
ATGGCGGCGGTGGTCGCACTCTCCTTGAGGCGCCGGTTGCCGGCCACAACCCTTGGCGGA
GCCTGCCTGCAGGCCTCCCGAGGAGCCCAGACAGCTGCAGCCACAGCTCCCCGTATCAAG
AAATTTGCCATCTATCGATGGGACCCAGACAAGGCTGGAGACAAACCTCATATGCAGACT
TATAAGGTTGACCTTAATAAATGTGGCCCCATGGTATTGGATGCTTTAATCAAGATTAAG
AATGAAGTTGACTCTACTTTGACCTTCCGAAGATCATGCAGAGAAGGCATCTGTGGCTCT
TGTGCAATGAACATCAATGGAGGCAACACTCTAGCTTGCACCCGAAGGATTGACACCAAC
CTCAATAAGGTCTCAAAAATCTACCCTCTTCCACACATGTATGTGATAAAGGATCTTGTT
CCCGATTTGAGCAACTTCTATGCACAGTACAAATCCATTGAGCCTTATTTGAAGAAGAAG
GATGAATCTCAGGAAGGCAAGCAGCAGTATCTGCAGTCCATAGAAGAGCGTGAGAAACTG
GACGGGCTCTACGAGTGCATTCTCTGTGCCTGCTGTAGCACCAGCTGCCCCAGCTACTGG
TGGAACGGAGACAAATATCTGGGGCCTGCAGTTCTTATGCAGGCCTATCGCTGGATGATT
GACTCCAGAGATGACTTCACAGAGGAGCGCCTGGCCAAGCTGCAGGACCCATTCTCTCTA
TACCGCTGCCACACCATCATGAACTGCACAAGGACCTGTCCTAAGGGTCTGAATCCAGGG
AAAGCTATTGCAGAGATCAAGAAAATGATGGCAACCTATAAGGAGAAGAAAGCTTCAGTT
TAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U17248

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_3_Locus:
1p36.1-p35

# Metabolic_Enzyme_3_SNPs:
rs33927012; rs2746462; rs2235930; rs2647145; rs1022580; rs2746463; rs2746466; rs2235928; rs2746472; rs2295057; rs978528; rs10887990; rs2295058; rs6700594; rs761420; rs2871775; rs732679; rs2295059; rs11582579; rs4920653; rs7545499; rs2295060; rs6586494; rs2647155; rs9435746; rs2746465; rs6698160; rs9325648; rs2179793; rs2647162; rs7536679; rs2746469; rs11203284; rs10887991; rs2235931; rs6586496; rs2746474; rs9435747; rs2647146; rs7545518; rs12045097; rs6701200; rs6690919; rs7550829; rs9325647; rs2235929; rs2746473; rs6690934; rs1546925; rs11203287; rs11203281; rs2746468; rs12066331; rs12122144; rs9435745; rs12073028; rs2647157; rs2746464; rs11203282; rs1546926; rs7513044; rs2179792; rs2746475; rs11579172; rs10887993; rs11578903; rs11203288; rs9435676; rs10887994; rs12127019; rs7517920; rs11203285; rs6699999; rs9787230; rs10887992; rs11203286; rs11579925; rs2647161; rs6586497; rs2746476; rs9435749; rs10788650; rs2647156; rs2647158; rs12562307; rs2746467; rs2647209; rs3754509; rs2746461; rs2647211; rs2647165; rs9435741; rs2746460; rs34599281; rs34916635; rs35962811; rs34309090; rs11203289; rs11541234; rs41310416; rs35417465; rs34633163; rs2295056; rs12024874; rs12745076; rs12141920; rs35938342; rs35456786; rs12730812; rs2647169; rs34993330; rs4920404; rs34472779; rs34261028; rs9435748; rs910213; rs36027267; rs12085825; rs12143126; rs34846742; rs34275114; rs6672261; rs6703561; rs34436415; rs12144355; rs12025897; rs6696035; rs35379313; rs4920290; rs34200008; rs3036957; rs34105277; rs35846145; rs4920390; rs12094223; rs35453444; rs11579443; rs41273161; rs2311484; rs34841128; rs34853585; rs6664408; rs2647163; rs12402936; rs35223568; rs11577071; rs9435744; rs34415894; rs11203283; rs12722796; rs12747579; rs35841405; rs12062603; rs35499913; rs9435743; rs35921088; rs34391175; rs6691029; rs34604620; rs12725925; rs34806121; rs34561776; rs11801098; rs3036956; rs2647159; rs35602067; rs35298846; rs35967918; rs6665176; rs2746471; rs17466602; rs34926449; rs2647164; rs33922771; rs7554763; rs12063457; rs12142244; rs2647160; rs12747436; rs35291982; rs34218856; rs3036955; rs4920648; rs12122916; rs12737199; rs11799540; rs35897475; rs7517571; rs35813993; rs35029966; rs12142023; rs35655194; rs12068317; rs41310418; rs35835426; rs2647210; rs12140522; rs34674434; rs7543309; rs4920621; rs35258340; rs2746477; rs34724371; rs12141502; rs35394060; rs11203280; rs11203290; rs12078020; rs12126285; rs12404121; rs12728190; rs2076600; rs2647166; rs2647167; rs2647168; rs2647208; rs2746542; rs2746543; rs2746544; rs34410889; rs34733140; rs35496797; rs3754507; rs3754508; rs4920442; rs926702; rs9435739

# Metabolic_Enzyme_3_General_References:
7622059; 2302193; 2494655

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5970

# Metabolic_Enzyme_4_Name:
Argininosuccinate lyase

# Metabolic_Enzyme_4_Synonyms:
Arginosuccinase; ASAL

# Metabolic_Enzyme_4_Gene_Name:
ASL

# Metabolic_Enzyme_4_Protein_Sequence:
>Argininosuccinate lyase
MASESGKLWGGRFVGAVDPIMEKFNASIAYDRHLWEVDVQGSKAYSRGLEKAGLLTKAEM
DQILHGLDKVAEEWAQGTFKLNSNDEDIHTANERRLKELIGATAGKLHTGRSRNDQVVTD
LRLWMRQTCSTLSGLLWELIRTMVDRAEAERDVLFPGYTHLQRAQPIRWSHWILSHAVAL
TRDSERLLEVRKRINVLPLGSGAIAGNPLGVDRELLRAELNFGAITLNSMDATSERDFVA
EFLFWASLCMTHLSRMAEDLILYCTKEFSFVQLSDAYSTGSSLMPQKKNPDSLELIRSKA
GRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFEVSDTMSAVLQVATGVISTLQIHQENM
GQALSPDMLATDLAYYLVRKGMPFRQAHEASGKAVFMAETKGVALNQLSLQELQTISPLF
SGDVICVWDYGHSVEQYGALGGTARSSVDWQIRQVRALLQAQQA

# Metabolic_Enzyme_4_Number_of_Residues:
464

# Metabolic_Enzyme_4_Molecular_Weight:
51659

# Metabolic_Enzyme_4_Theoretical_pI:
6.45

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
2-(omega-N-L-arginino)succinate = fumarate + L-arginine

# Metabolic_Enzyme_4_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00252  Alanine and aspartate metabolism;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_4_Reaction:
(N(omega)-L-arginino)succinate = fumarate + L-arginine

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00206:Lyase_1

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 4.3.2.1

# Metabolic_Enzyme_4_GenBank_ID_Protein:
28878

# Metabolic_Enzyme_4_SwissProt_ID:
ARLY_HUMAN (P04424)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
ASL

# Metabolic_Enzyme_4_Geneatlas_id:
ASL

# Metabolic_Enzyme_4_hgnc_id:
HGNC:746

# Metabolic_Enzyme_4_PDB_ID:
1K62

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>1395 bp
ATGGCCTCGGAGAGTGGGAAGCTTTGGGGTGGCCGGTTTGTGGGTGCAGTGGACCCCATC
ATGGAGAAGTTCAACGCGTCCATTGCCTACGACCGGCACCTTTGGGAGGTGGATGTTCAA
GGCAGCAAAGCCTACAGCAGGGGCCTGGAGAAGGCAGGGCTCCTCACCAAGGCCGAGATG
GACCAGATACTCCATGGCCTAGACAAGGTGGCTGAGGAGTGGGCCCAGGGCACCTTCAAA
CTGAACTCCAATGATGAGGACATCCACACAGCCAATGAGCGCCGCCTGAAGGAGCTCATT
GGTGCAACGGCAGGGAAGCTGCACACGGGACGGAGCCGGAATGACCAGGTGGTCACAGAC
CTCAGGCTGTGGATGCGGCAGACCTGCTCCACGCTCTCGGGCCTCCTCTGGGAGCTCATT
AGGACCATGGTGGATCGGGCAGAGGCGGAACGTGATGTTCTCTTCCCGGGGTACACCCAT
TTGCAGAGGGCCCAGCCCATCCGCTGGAGCCACTGGATTCTGAGCCACGCCGTGGCACTG
ACCCGAGACTCTGAGCGGCTGCTGGAGGTGCGGAAGCGGATCAATGTCCTGCCCCTGGGG
AGTGGGGCCATTGCAGGCAATCCCCTGGGTGTGGACCGAGAGCTGCTCCGAGCAGAACTC
AACTTTGGGGCCATCACTCTCAACAGCATGGATGCCACTAGTGAGCGGGACTTTGTGGCC
GAGTTCCTGTTCTGGCGTTCGCTGTGCATGACCCATCTCAGCAGGATGGCCGAGGACCTC
ATCCTCTACTGCACCAAGGAATTCAGCTTCGTGCAGCTCTCAGATGCCTACAGCACGGGA
AGCAGCCTGATGCCCCAGAAGAAAAACCCCGACAGTTTGGAGCTGATCCGGAGCAAGGCT
GGGCGTGTGTTTGGGCGGTGTGCCGGGCTCCTGATGACCCTCAAGGGACTTCCCAGCACC
TACAACAAAGACTTACAGGAGGACAAGGAAGCTGTGTTTGAAGTGTCAGACACTATGAGT
GCCGTGCTCCAGGTGGCCACTGGCGTCATCTCTACGCTGCAGATTCACCAAGAGAACATG
GGACAGGCTCTCAGCCCCGACATGCTGGCCACTGACCTTGCCTATTACCTGGTCCGCAAA
GGGATGCCATTCCGCCAGGCCCATGAGGCCTCCGGGAAAGCTGTGTTCATGGCCGAGACC
AAGGGGGTCGCCCTCAACCAGCTGTCACTGCAGGAGCTGCAGACCATCAGCCCCCTGTTC
TCGGGCGACGTGATCTGCGTGTGGGACTACCGGCACAGTGTGGAGCAGTATGGTGCCCTG
GGCGGCACTGCGCGCTCCAGCGTCGACTGGCAAATCCGCCAGGTGCGGGCGCTACTGCAG
GCACAGCAGGCCTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
Y00753

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_4_Locus:
7cen-q11.2

# Metabolic_Enzyme_4_SNPs:
rs465359; rs160644; rs462853; rs1167406; rs1144895; rs313830; rs313829; rs12530898; rs1167408; rs2460432; rs160648; rs1183245; rs780998; rs2220626; rs10276931; rs12536292; rs316336; rs160647; rs160657; rs160646; rs160645; rs313831; rs697969; rs7455802; rs7455801; rs3116476; rs28941472; rs3107306; rs28940585; rs160643; rs34720698; rs2292938; rs35348667; rs4281011; rs160649; rs35930194; rs313828; rs13247295; rs35529535; rs34583147; rs34661440; rs6955131; rs160656; rs1144894; rs35350184; rs6967430; rs313833; rs313832; rs10699464; rs28447397; rs28566023; rs160543; rs35718690; rs7812266; rs10247708; rs160642; rs35701961; rs1167411; rs10234562; rs12531358; rs12532327; rs160652; rs160654; rs697970; rs709609

# Metabolic_Enzyme_4_General_References:
3391281; 3463959; 2644168; 9256435; 11747432; 1705937; 2263616; 12408190

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
6142

# Metabolic_Enzyme_5_Name:
Fumarate hydratase, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
Fumarase

# Metabolic_Enzyme_5_Gene_Name:
FH

# Metabolic_Enzyme_5_Protein_Sequence:
>Fumarate hydratase, mitochondrial precursor
MYRALRLLARSRPLVRAPAAALASAPGLGGAAVPSFWPPNAARMASQNSFRIEYDTFGEL
KVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAI
MKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDH
VNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAV
PLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAAL
TGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPE
NEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSA
RLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGS
TLKETAIELGYLTAEQFDEWVKPKDMLGPK

# Metabolic_Enzyme_5_Number_of_Residues:
510

# Metabolic_Enzyme_5_Molecular_Weight:
54638

# Metabolic_Enzyme_5_Theoretical_pI:
9.17

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-oxygen lyase activity
Function:  hydro-lyase activity
Function:  fumarate hydratase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  fumarate metabolism
 ||
>>>
Component:  protein complex
Component:  tricarboxylic acid cycle enzyme complex

# Metabolic_Enzyme_5_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_5_Specific_Function:
Also acts as a tumor suppressor

# Metabolic_Enzyme_5_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_5_Reaction:
(S)-malate = fumarate + H2O

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00206:Lyase_1

# Metabolic_Enzyme_5_Signals:
1-23

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 4.2.1.2

# Metabolic_Enzyme_5_GenBank_ID_Protein:
1545996

# Metabolic_Enzyme_5_SwissProt_ID:
FUMH_HUMAN (P07954)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
FH

# Metabolic_Enzyme_5_Geneatlas_id:
FH

# Metabolic_Enzyme_5_hgnc_id:
HGNC:3700

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion. Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1533 bp
ATGTACCGAGCACTTCGGCTCCTCGCGCGCTCGCGTCCCCTCGTGCGGGCTCCAGCCGCA
GCCTTAGCTTCGGCTCCCGGCTTGGGTGGCGCGGCCGTGCCCTCGTTTTGGCCTCCGAAC
GCGGCTCGAATGGCAAGCCAAAATTCCTTCCGGATAGAATATGATACCTTTGGTGAACTA
AAGGTGCCAAATGATAAGTATTATGGCGCCCAGACCGTGAGATCTACGATGAACTTTAAG
ATTGGAGGTGTGACAGAACGCATGCCAACCCCAGTTATTAAAGCTTTTGGCATCTTGAAG
CGAGCGGCCGCTGAAGTAAACCAGGATTATGGTCTTGATCCAAAGATTGCTAATGCAATA
ATGAAGGCAGCAGATGAGGTAGCTGAAGGTAAATTAAATGATCATTTTCCTCTCGTGGTA
TGGCAGACTGGATCAGGAACTCAGACAAATATGAATGTAAATGAAGTCATTAGCAATAGA
GCAATTGAAATGTTAGGAGGTGAACTTGGCAGCAAGATACCTGTGCATCCCAACGATCAT
GTTAATAAAAGCCAGAGCTCAAATGATACTTTTCCCACAGCAATGCACATTGCTGCTGCA
ATAGAAGTTCATGAAGTACTGTTACCAGGACTACAGAAGTTACATGATGCTCTTGATGCA
AAATCCAAAGAGTTTGCACAGATCATCAAGATTGGACGTACTCATACTCAGGATGCTGTT
CCACTTACTCTTGGGCAGGAATTTAGTGGTTATGTTCAACAAGTAAAATATGCAATGACA
AGAATAAAAGCTGCCATGCCAAGAATCTATGAGCTCGCAGCTGGAGGCACTGCTGTTGGT
ACAGGTTTAAATACTAGAATTGGCTTTGCAGAAAAGGTTGCTGCAAAAGTGGCTGCACTT
ACAGGCTTGCCTTTTGTCACTGCTCCGAATAAATTTGAAGCTCTGGCTGCTCATGACGCT
CTGGTTGAGCTCAGTGGAGCCATGAACACTACTGCCTGCAGTCTGATGAAGATAGCAAAT
GATATTCGATTTTTGGGTTCTGGTCCTCGGTCAGGTCTGGGAGAATTGATCTTGCCTGAA
AATGAACCAGGAAGCAGTATCATGCCAGGCAAGGTGAACCCTACTCAGTGTGAAGCAATG
ACCATGGTTGCAGCCCAAGTCATGGGGAACCATGTTGCTGTCACTGTCGGAGGCAGCAAT
GGACATTTTGAGTTGAATGTTTTCAAGCCAATGATGATTAAAAATGTGTTACACTCAGCC
AGGCTGCTGGGGGATGCTTCAGTTTCCTTTACAGAAAACTGCGTGGTGGGAATCCAGGCC
AATACAGAAAGGATCAACAAGCTGATGAATGAGTCTCTAATGTTGGTGACAGCTCTCAAT
CCTCATATAGGGTATGACAAGGCAGCAAAGATTGCTAAGACAGCACACAAAAATGGATCA
ACCTTAAAGGAAACTGCTATCGAACTTGGCTATCTCACAGCAGAGCAGTTTGACGAATGG
GTAAAACCTAAGGACATGCTGGGTCCAAAGTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U59309

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_5_Locus:
1q42.1

# Metabolic_Enzyme_5_SNPs:
rs1335898; rs4659607; rs2994990; rs2992644; rs11802956; rs2185626; rs3014577; rs11810820; rs10802968; rs4660099; rs12563264; rs6673988; rs4659606; rs11810810; rs10926500; rs10926499; rs12065955; rs12062672; rs1572380; rs2275162; rs4659608; rs11809211; rs4660098; rs12072899; rs12059383; rs12085636; rs2225788; rs2153694; rs947306; rs7530270; rs6678986; rs2153695; rs12071124; rs7414794; rs6679186; rs6681649; rs11545656; rs11545658; rs11545659; rs11545654; rs11545655; rs10926501; rs1049719; rs12087951; rs36061522; rs35911339; rs35806536; rs34169563; rs11811744; rs3014576; rs34340049; rs34519169; rs2341940; rs6689999; rs36216713; rs5782200; rs34461266; rs28593473; rs12059375; rs35459191; rs5782199; rs12058914; rs35724406; rs34171219; rs5782201; rs12759839; rs12057640; rs6143706; rs2992645; rs11463263; rs2341941; rs12047049; rs12075683; rs10548903; rs35416457; rs34827919; rs10560801; rs12401442; rs10926503; rs16841808; rs12754502; rs34007305; rs5782198; rs34516025; rs10754730; rs11810451; rs1414493; rs2994986; rs2994989; rs4431830; rs4601574; rs4660101; rs6678766; rs6693420; rs7514407; rs7536335; rs9729137

# Metabolic_Enzyme_5_General_References:
3828494; 9635293; 11865300

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5411

# Metabolic_Enzyme_6_Name:
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor

# Metabolic_Enzyme_6_Synonyms:
CybS; Succinate-ubiquinone reductase membrane anchor subunit; QPs3; CII-4; Succinate dehydrogenase complex subunit D; Succinate-ubiquinone oxidoreductase cytochrome b small subunit

# Metabolic_Enzyme_6_Gene_Name:
SDHD

# Metabolic_Enzyme_6_Protein_Sequence:
>Succinate dehydrogenase ubiquinone cytochrome b small subunit, mitochondrial precursor
MAVLWRLSAVCGALGGRALLLRTPVVRPAHISAFLQDRPIPEWCGVQHIHLSPSHHSGSK
AASLHWTSERVVSVLLLGLLPAAYLNPCSAMDYSLAAALTLHGHWGLGQVVTDYVHGDAL
QKAAKAGLLALSALTFAGLCYFNYHDVGICKAVAMLWKL

# Metabolic_Enzyme_6_Number_of_Residues:
159

# Metabolic_Enzyme_6_Molecular_Weight:
17043

# Metabolic_Enzyme_6_Theoretical_pI:
8.75

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  binding
Function:  tetrapyrrole binding
Function:  heme binding
 ||
>>>
Process:  electron transport
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  envelope
Component:  organelle envelope
Component:  mitochondrial envelope

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Not Available

# Metabolic_Enzyme_6_Pathway:
Not Available

# Metabolic_Enzyme_6_Reaction:
Not Available

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF05328:CybS

# Metabolic_Enzyme_6_Signals:
1-18

# Metabolic_Enzyme_6_Transmembrane_Regions:
71-91
126-142

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.3.5.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
2351037

# Metabolic_Enzyme_6_SwissProt_ID:
DHSD_HUMAN (O14521)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
SDHD

# Metabolic_Enzyme_6_Geneatlas_id:
SDHD

# Metabolic_Enzyme_6_hgnc_id:
HGNC:10683

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane; multi-pass membrane protein

# Metabolic_Enzyme_6_Gene_Sequence:
>480 bp
ATGGCGGTTCTCTGGAGGCTGAGTGCCGTTTGCGGTGCCCTAGGAGGCCGAGCTCTGTTG
CTTCGAACTCCAGTGGTCAGACCTGCTCATATCTCAGCATTTCTTCAGGACCGACCTATC
CCAGAATGGTGTGGAGTGCAGCACATACACTTGTCACCGAGCCACCATTCTGGCTCCAAG
GCTGCATCTCTCCACTGGACTAGCGAGAGGGTTGTCAGTGTTTTGCTCCTGGGTCTGCTT
CCGGCTGCTTATTTGAATCCTTGCTCTGCGATGGACTATTCCCTGGCTGCAGCCCTCACT
CTTCATGGTCACTGGGGCCTTGGACAAGTTGTTACTGACTATGTTCATGGGGATGCCTTG
CAGAAAGCTGCCAAGGCAGGGCTTTTGGCACTTTCAGCTTTAACCTTTGCTGGGCTTTGC
TATTTCAACTATCACGATGTGGGCATCTGCAAAGCTGTTGCCATGCTGTGGAAGCTCTGA


# Metabolic_Enzyme_6_GenBank_ID_Gene:
AB006202

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_6_Locus:
11q23

# Metabolic_Enzyme_6_SNPs:
rs9919552; rs693441; rs17113461; rs9919624; rs4151637; rs10789859; rs530937; rs7935331; rs7122054; rs11214078; rs10749989; rs10891318; rs557519; rs11214079; rs11547884; rs2517974; rs1300212; rs12291484; rs1648188; rs9666423; rs1299335; rs592626; rs35404297; rs2517973; rs2852375; rs35962669; rs35706705; rs2517975; rs12277821; rs10255; rs10812; rs10891319; rs1139692; rs12292526; rs12804323; rs14396; rs3809034; rs3891460; rs4025979; rs487201; rs498547; rs523559; rs544184; rs7121782; rs7123075; rs7127061; rs7944155

# Metabolic_Enzyme_6_General_References:
9533030; 11156372; 10657297; 11343322; 11391796; 11391798; 11526495; 12007193; 12696072

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5382

# Metabolic_Enzyme_7_Name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor

# Metabolic_Enzyme_7_Synonyms:
Fp; Flavoprotein subunit of complex II

# Metabolic_Enzyme_7_Gene_Name:
SDHA

# Metabolic_Enzyme_7_Protein_Sequence:
>Succinate dehydrogenase ubiquinone flavoprotein subunit, mitochondrial precursor
MSGVRGLSRLLSARRLALAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDSISAQYPVVDH
EFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWR
WHFYDTVKGSDWLGDQDAIHYMTEQAPAAVVELENYGMPFSRTEDGKIYQRAFGGQSLKF
GKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIE
DGSIHRIRAKNTVVATGGYGRTYFSCTSAHTSTGDGTAMITRAGLPCQDLEFVQFHPTGI
YGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPE
KDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQ
VLRHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIEESCRPGDK
VPPIKPNAGEESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCGKIS
KLYGDLKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVR
IDEYDYSKPIQGQQKKPFEEHWRKHTLSYVDVGTGKVTLEYRPVIDKTLNEADCATVPPA
IRSY

# Metabolic_Enzyme_7_Number_of_Residues:
664

# Metabolic_Enzyme_7_Molecular_Weight:
72692

# Metabolic_Enzyme_7_Theoretical_pI:
7.41

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  FAD binding
Function:  oxidoreductase activity, acting on the CH-CH group of donors
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_7_Specific_Function:
Succinate + ubiquinone = fumarate + ubiquinol

# Metabolic_Enzyme_7_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00190  Oxidative phosphorylation

# Metabolic_Enzyme_7_Reaction:
succinate + ubiquinone = fumarate + ubiquinol

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00890:FAD_binding_2;
PF02910:Succ_DH_flav_C

# Metabolic_Enzyme_7_Signals:
1-19

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.3.5.1

# Metabolic_Enzyme_7_GenBank_ID_Protein:
506338

# Metabolic_Enzyme_7_SwissProt_ID:
DHSA_HUMAN (P31040)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
SDHA

# Metabolic_Enzyme_7_Geneatlas_id:
SDHA

# Metabolic_Enzyme_7_hgnc_id:
HGNC:10680

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane

# Metabolic_Enzyme_7_Gene_Sequence:
>1995 bp
ATGTCGGGGGTCCGGGGCCTGTCGCGGCTGCTGAGCGCTCGGCGCCTGGCGCTGGCCAAG
GCGTGGCCAACAGTGTTGCAAACAGGAACCCGAGGTTTTCACTTCACTGTTGATGGGAAC
AAGAGGGCATCTGCTAAAGTTTCAGATTCCATTTCTGCTCAGTATCCAGTAGTGGATCAT
GAATTTGATGCAGTGGTGGTAGGCGCTGGAGGGGCAGGCTTGCGAGCTGCATTTGGCCTT
TCTGAGGCAGGGTTTAATACAGCATGTGTTACCAAGCTGTTTCCTACCAGGTCACACACT
GTTGCAGCACAGGGAGGAATCAATGCTGCTCTGGGGAACATGGAGGAGGACAACTGGAGG
TGGCATTTCTACGACACCGTGAAGGGCTCCGACTGGCTGGGGGACCAGGATGCCATCCAC
TACATGACGGAGCAGGCCCCCGCCGCCGTGGTCGAGCTAGAAAATTATGGCATGCCGTTT
AGCAGAACTGAAGATGGGAAGATTTATCAGCGTGCATTTGGTGGACAGAGCCTCAAGTTT
GGAAAGGGCGGGCAGGCCCATCGGTGCTGCTGTGTGGCTGATCGGACTGGCCACTCGCTA
TTGCACACCTTATATGGACGGTCTCTGCGATATGATACCAGCTATTTTGTGGAGTATTTT
GCCTTGGATCTCCTGATGGAGAACGGGGAGTGCCGTGGTGTCATCGCACTGTGCATAGAG
GACGGGTCCATCCATCGCATAAGAGCAAAGAACACTGTTGTTGCCACAGGAGGCTACGGG
CGCACCTACTTCAGCTGCACGTCTGCCCACACCAGCACTGGCGACGGCACGGCCATGATC
ACCAGGGCAGGCCTTCCTTGCCAGGACCTAGAGTTTGTTCAGTTCCACCCTACAGGCATA
TATGGTGCTGGTTGTCTCATTACGGAAGGATGTCGTGGAGAGGGAGGCATTCTCATTAAC
AGTCAAGGCGAAAGGTTTATGGAGCGATACGCCCCTGTCGCGAAGGACCTGGCGTCTAGA
GATGTGGTGTCTCGGTCCATGACTCTGGAGATCCGAGAAGGAAGAGGCTGTGGCCCTGAG
AAAGATCACGTCTACCTGCAGCTGCACCACCTACCTCCAGAGCAGCTGGCCACGCGCCTG
CCTGGCATTTCAGAGACAGCCATGATCTTCGCTGGCGTGGACGTCACGAAGGAGCCGATC
CCTGTCCTCCCCACCGTGCATTATAACATGGGCGGCATTCCCACCAACTACAAGGGGCAG
GTCCTGAGGCACGTGAATGGCCAGGATCAGATTGTGCCCGGCCTGTACGCCTGTGGGGAG
GCCGCCTGTGCCTCGGTACATGGTGCCAACCGCCTCGGGGCAAACTCGCTCTTGGACCTG
GTTGTCTTTGGTCGGGCATGTGCCCTGAGCATCGAAGAGTCATGCAGGCCTGGAGATAAA
GTCCCTCCAATTAAACCAAACGCTGGGGAAGAATCTGTCATGAATCTTGACAAATTGAGA
TTTGCTGATGGAAGCATAAGAACATCGGAACTGCGACTCAGCATGCAGAAGTCAATGCAA
AATCATGCTGCCGTGTTCCGTGTGGGAAGCGTGTTGCAAGAAGGTTGTGGGAAAATCAGC
AAGCTCTATGGAGACCTAAAGCACCTGAAGACGTTCGACCGGGGAATGGTCTGGAACACG
GACCTGGTGGAGACCCTGGAGCTGCAGAACCTGATGCTGTGTGCGCTGCAGACCATCTAC
GGAGCAGAGGCACGGAAGGAGTCACGGGGCGCGCATGCCAGGGAAGACTACAAGGTGCGG
ATTGATGAGTACGATTACTCCAAGCCCATCCAGGGGCAACAGAAGAAGCCCTTTGAGGAG
CACTGGAGGAAGCACACCCTGTCCTATGTGGACGTTGGCACTGGGAAGGTCACTCTGGAA
TATAGACCCGTGATCGACAAAACTTTGAACGAGGCTGACTGTGCCACCGTCCCGCCAGCC
ATTCGCTCCTACTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
D30648

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_7_Locus:
5p15

# Metabolic_Enzyme_7_SNPs:
rs6962; rs1062468; rs1041946; rs1061518; rs6888348; rs1042457; rs34635677; rs6555055; rs10042922; rs1126417; rs2115272; rs1041963; rs1042446; rs34771391; rs13070; rs1126427; rs1041947; rs17415917; rs1041949; rs1062467; rs10039029; rs1042518; rs1042539; rs1042476; rs1042525; rs1042554; rs1042565; rs6864807; rs7714944; rs6878087; rs6888536; rs11133943; rs7732389; rs7725227; rs2241600; rs2288459; rs7705721; rs2288458; rs7710005; rs2288457; rs6555058; rs10075018; rs10055354; rs3213838; rs1968374; rs6555059; rs10475136; rs7736600; rs6881920; rs1968375; rs3975683; rs10043002; rs6555050; rs10037861; rs6874921; rs10475142; rs6878237; rs6871034; rs6893024; rs2288456; rs6873679; rs2288461; rs6879986; rs10036253; rs6873678; rs6888378; rs10475141; rs6555051; rs7706899; rs185038; rs2288455; rs10079760; rs6555057; rs2864958; rs7706416; rs10042604; rs6885693; rs9687898; rs7719932; rs6555056; rs3764982; rs6555049; rs3213839; rs9688031; rs6555052; rs7708515; rs7708182; rs10037851; rs6878030; rs7724921; rs35947614; rs1814579; rs11133942; rs7706696; rs11956656; rs9312993; rs10080225; rs10060206; rs7714306; rs7720395; rs7721435; rs4957005; rs7720313; rs10060259; rs7737077; rs2162869; rs7725241; rs10053800; rs4582328; rs10045618; rs7730503; rs7719140; rs10066474; rs7722017; rs1809232; rs13354585; rs10055765; rs7714935; rs9312980; rs13160257; rs10057346; rs12520059; rs6878061; rs10064061; rs9687155; rs10066185; rs9312977; rs10052012; rs10059220; rs11746994; rs10069197; rs10074892; rs936341; rs34747801; rs3948431; rs12517832; rs9688136; rs10074958; rs7702330; rs10462611; rs7715101; rs10058428; rs10071431; rs10067355; rs9716070; rs10055295; rs7714931; rs7715696; rs4957004; rs9716341; rs13357769; rs2115271; rs7714803; rs4957002; rs10070389; rs10057501; rs6874572; rs6882584; rs10036908; rs10462753; rs6870228; rs10072139; rs4957003; rs35464369; rs13357299; rs6859587; rs4956930; rs10057492; rs12522769; rs1126415; rs1042056; rs1061520; rs1042052; rs1061519; rs3211483; rs1041948; rs11557099; rs41495051; rs1042170; rs34779890; rs1041950; rs3211499; rs1139424; rs3181540; rs1126538; rs35964044; rs35502109; rs1042430; rs35277230; rs1042598; rs1804911; rs7705305; rs13173890; rs12332382; rs9312979; rs13156023; rs12332380; rs10061759; rs10077076; rs10462754; rs34815560; rs10050916; rs13356384; rs414187; rs28418643; rs13356367; rs41304878; rs6882086; rs34016296; rs13153342; rs10056853; rs10051065; rs9312984; rs13168268; rs13181285; rs35196055; rs6886749; rs34443708; rs10050994; rs35406030; rs11742454; rs35091472; rs13436945; rs10057299; rs10060016; rs7706740; rs10052155; rs10057677; rs3217327; rs4588630; rs34454330; rs6873834; rs13356383; rs685081; rs4957006; rs13175598; rs10041187; rs10060080; rs10045592; rs10055642; rs10036297; rs10065584; rs9688144; rs9312983; rs13180377; rs10462755; rs13356800; rs11958564; rs28729548; rs34567554; rs4957001; rs400174; rs35908745; rs9687909; rs11460991; rs2162870; rs34572225; rs7442707; rs10067021; rs4956999; rs7444613; rs4975667; rs10055643; rs41282617; rs6887802; rs10061678; rs10074903; rs28731093; rs13155531; rs10055812; rs6873844; rs33952048; rs9687621; rs10057678; rs34444921; rs10041277; rs10069074; rs13168281; rs13185981; rs35932361; rs10078265; rs11740220; rs387134; rs33957995; rs13186145; rs13360554; rs3835068; rs10057626; rs12332457; rs34955651; rs10074830; rs28710899; rs35549341; rs9688045; rs28641621; rs10076655; rs9687745; rs35007954; rs28474882; rs10062085; rs4956929; rs10035598; rs35021524; rs9312978; rs35021571; rs7445509; rs7711955; rs10051622; rs1061517; rs2303741; rs2864963; rs3211464; rs3756715; rs3756717; rs6861223; rs6869925; rs6872854; rs6896634; rs7726542

# Metabolic_Enzyme_7_General_References:
7798181; 8142412; 7550341; 12794685

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5986

# Metabolic_Enzyme_8_Name:
Fumarylacetoacetase

# Metabolic_Enzyme_8_Synonyms:
Fumarylacetoacetate hydrolase; Beta-diketonase; FAA

# Metabolic_Enzyme_8_Gene_Name:
FAH

# Metabolic_Enzyme_8_Protein_Sequence:
>Fumarylacetoacetase
MSFIPVAEDSDFPIHNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKHLFTGPVLSKHQD
VFNQPTLNSFMGLGQAAWKEARVFLQNLLSVSQARLRDDTELRKCAFISQASATMHLPAT
IGDYTDFYSSRQHATNVGIMFRDKENALMPNWLHLPVGYHGRASSVVVSGTPIRRPMGQM
KPDDSKPPVYGACKLLDMELEMAFFVGPGNRLGEPIPISKAHEHIFGMVLMNDWSARDIQ
KWEYVPLGPFLGKSFGTTVSPWVVPMDALMPFAVPNPKQDPRPLPYLCHDEPYTFDINLS
VNLKGEGMSQAATICKSNFKYMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGPEPENFG
SMLELSWKGTKPIDLGNGQTRKFLLDGDEVIITGYCQGDGYRIGFGQCAGKVLPALLPS

# Metabolic_Enzyme_8_Number_of_Residues:
419

# Metabolic_Enzyme_8_Molecular_Weight:
46375

# Metabolic_Enzyme_8_Theoretical_pI:
6.94

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid carbon-carbon bonds
Function:  hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances
Function:  fumarylacetoacetase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_8_Specific_Function:
4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate

# Metabolic_Enzyme_8_Pathway:
map00350  Tyrosine metabolism;
 map00643  Styrene degradation

# Metabolic_Enzyme_8_Reaction:
4-fumarylacetoacetate + H2O = acetoacetate + fumarate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF09298:DUF1969;
PF01557:FAA_hydrolase

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.7.1.2

# Metabolic_Enzyme_8_GenBank_ID_Protein:
182393

# Metabolic_Enzyme_8_SwissProt_ID:
FAAA_HUMAN (P16930)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
FAH

# Metabolic_Enzyme_8_Geneatlas_id:
FAH

# Metabolic_Enzyme_8_hgnc_id:
HGNC:3579

# Metabolic_Enzyme_8_PDB_ID:
1QQJ

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_8_Gene_Sequence:
>1260 bp
ATGTCCTTCATCCCGGTGGCCGAGGATTCCGACTTCCCCATCCACAACCTGCCCTACGGC
GTCTTCTCGACCAGAGGCGACCCAAGACCGAGGATAGGTGTGGCCATTGGCGACCAGATC
CTGGACCTCAGCATCATCAAGCACCTCTTTACTGGTCCTGTCCTCTCCAAACACCAGGAT
GTCTTCAATCAGCCTACACTCAACAGCTTCATGGGCCTGGGTCAGGCTGCCTGGAAGGAG
GCGAGAGTGTTCTTGCAGAACTTGCTGTCTGTGAGCCAAGCCAGGCTCAGAGATGACACC
GAACTTCGGAAGTGTGCATTCATCTCCCAGGCTTCTGCCACGATGCACCTTCCAGCCACC
ATAGGAGACTACACAGACTTCTATTCCTCTCGGCAGCATGCTACCAACGTCGGAATCATG
TTCAGGGACAAGGAGAATGCGTTGATGCCAAATTGGCTGCACTTACCAGTGGGCTACCAT
GGCCGTGCCTCCTCTGTCGTGGTGTCTGGCACCCCAATCCGAAGGCCCATGGGACAGATG
AAACCTGATGACTCTAAGCCTCCCGTATATGGTGCCTGCAAGCTCTTGGACATGGAGCTG
GAAATGGCTTTTTTTGTAGGCCCTGGAAACAGATTGGGAGAGCCGATCCCCATTTCCAAG
GCCCATGAGCACATTTTTGGAATGGTCCTTATGAACGACTGGAGTGCACGAGACATTCAG
AAGTGGGAGTATGTCCCTCTCGGGCCATTCCTTGGGAAGAGTTTTGGGACCACTGTCTCT
CCGTGGGTGGTGCCCATGGATGCTCTCATGCCCTTTGCTGTGCCCAACCCGAAGCAGGAC
CCCAGGCCCCTGCCGTATCTGTGCCATGACGAGCCCTACACATTTGACATCAACCTCTCT
GTTAACCTGAAAGGAGAAGGAATGAGCCAGGCGGCTACCATATGCAAGTCCAATTTTAAG
TACATGTACTGGACGATGCTGCAGCAGCTCACTCACCACTCTGTCAACGGCTGCAACCTG
CGGCCGGGGGACCTCCTGGCTTCTGGGACCATCAGCGGGCCGGAGCCAGAAAACTTCGGC
TCCATGTTGGAACTGTCGTGGAAGGGAACGAAGCCCATAGACCTGGGGAATGGTCAGACC
AGGAAGTTTCTGCTGGACGGGGATGAAGTCATCATAACAGGGTACTGCCAGGGGGATGGT
TACCGCATCGGCTTTGGCCAGTGTGCTGGAAAAGTGCTGCCTGCTCTCCTGCCATCATGA


# Metabolic_Enzyme_8_GenBank_ID_Gene:
M55150

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_8_Locus:
15q23-q25

# Metabolic_Enzyme_8_SNPs:
rs28733633; rs1801374; rs33929922; rs3189268; rs1049194; rs733679; rs2114716; rs2043692; rs1370276; rs1370274; rs3752692; rs12594576; rs2866591; rs4778758; rs1370273; rs1030865; rs8027831; rs8039712; rs7180031; rs2043691; rs8043131; rs8033974; rs10152142; rs2866592; rs8043254; rs11856427; rs2114706; rs7177977; rs1978817; rs2866593; rs2866594; rs2014531; rs7180267; rs1963890; rs1863768; rs11852901; rs2278205; rs2278204; rs6495477; rs1963889; rs1370277; rs4778583; rs1978816; rs1370275; rs12593746; rs12591114; rs3752693; rs6495478; rs7164048; rs11633719; rs1545119; rs16971777; rs2162550; rs16971784; rs11637869; rs7165316; rs6495476; rs13329170; rs12439250; rs17218165; rs12593304; rs12907580; rs17217997; rs11072883; rs3835063; rs12910663; rs12593724; rs12905358; rs12591184; rs7179137; rs8027913; rs11072882; rs12898576; rs16971779; rs7166889; rs11630172; rs7168949; rs2162552; rs11855351; rs8041120; rs11856039; rs8042782; rs11856087; rs11555097; rs11555096; rs34749737; rs1049165; rs35033541; rs36122289; rs3189275; rs1049181; rs3210172; rs3189271; rs1130438; rs34138675; rs12912992; rs12050831; rs28670686; rs34053230; rs35856260; rs3833032; rs28561542; rs10653816; rs7180879; rs35504528; rs12905208; rs7164212; rs2043693; rs11541885; rs11414483; rs28465485; rs35860708; rs10599000; rs28391413; rs35207990; rs3752694; rs12898575; rs28665646; rs34587722; rs34445460; rs11637479; rs35810566; rs3051263; rs35880073; rs8036972; rs35271165; rs8035131; rs28562328; rs7342660; rs3837742; rs28462237; rs34497292; rs28553552; rs35540542; rs9707913; rs12050830; rs9672598; rs11635433; rs12917072; rs11315019; rs34642735; rs34729999; rs28408765; rs34245126; rs35455610; rs35677503; rs1020056; rs11072885; rs11633099; rs12591328; rs12592943; rs12593705; rs12708527; rs12904314; rs1437221; rs1437222; rs16971826; rs1865998; rs34239630; rs35252136; rs4778757; rs4778760; rs713086; rs7172566; rs7174404; rs7175578; rs8025402; rs8026959; rs8040871; rs8041036

# Metabolic_Enzyme_8_General_References:
1998338; 2336361; 11278491; 9101289; 1401056; 8364576; 8318997; 7942842; 7977370; 8005583; 7757089; 7550234; 8557261; 9633815

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5353

# Metabolic_Enzyme_9_Name:
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor

# Metabolic_Enzyme_9_Synonyms:
Integral membrane protein CII-3; QPs1; QPs-1; Succinate dehydrogenase complex subunit C; Succinate-ubiquinone oxidoreductase cytochrome B large subunit; CYBL

# Metabolic_Enzyme_9_Gene_Name:
SDHC

# Metabolic_Enzyme_9_Protein_Sequence:
>Succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor
MAALLLRHVGRHCLRAHFSPQLCIRNAVPLGTTAKEEMERFWNKNIGSNRPLSPHITIYS
WSLPMAMSICHRGTGIALSAGVSLFGMSALLLPGNFESYLELVKSLCLGPALIHTAKFAL
VFPLMYHTWNGIRHLMWDLGKGLKIPQLYQSGVVVLVLTVLSSMGLAAM

# Metabolic_Enzyme_9_Number_of_Residues:
169

# Metabolic_Enzyme_9_Molecular_Weight:
18611

# Metabolic_Enzyme_9_Theoretical_pI:
10.12

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-CH group of donors
Function:  succinate dehydrogenase activity
 ||
>>>
Process:  electron transport
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_9_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_9_Specific_Function:
Mono-heme cytochrome b. May act as a mediator of low potential couples in an electron flow through cardiac complex II. Is involved in system II of the mitochondrial electron transport chain which is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)

# Metabolic_Enzyme_9_Pathway:
Not Available

# Metabolic_Enzyme_9_Reaction:
Not Available

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF01127:Sdh_cyt

# Metabolic_Enzyme_9_Signals:
1-16

# Metabolic_Enzyme_9_Transmembrane_Regions:
71-93
105-127
147-168

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 1.3.5.1

# Metabolic_Enzyme_9_GenBank_ID_Protein:
1814226

# Metabolic_Enzyme_9_SwissProt_ID:
C560_HUMAN (Q99643)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
SDHC

# Metabolic_Enzyme_9_Geneatlas_id:
SDHC

# Metabolic_Enzyme_9_hgnc_id:
HGNC:10682

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane; multi-pass membrane protein

# Metabolic_Enzyme_9_Gene_Sequence:
>510 bp
ATGGCTGCGCTGTTGCTGAGACACGTTGGTCGTCATTGCCTCCGAGCCCACTTTAGCCCT
CAGCTCTGTATCAGAAATGCTGTTCCTTTGGGAACCACGGCCAAAGAAGAGATGGAGCGG
TTCTGGAATAAGAATATAGGTTCAAACCGTCCTCTGTCTCCCCACATTACTATCTACAGT
TGGTCTCTTCCCATGGCGATGTCCATCTGCCACCGTGGCACTGGTATTGCTTTGAGTGCA
GGGGTCTCTCTTTTTGGCATGTCGGCCCTGTTACTCCCTGGGAACTTTGAGTCTTATTTG
GAACTTGTGAAGTCCCTGTGTCTGGGGCCAGCACTGATCCACACAGCTAAGTTTGCACTT
GTCTTCCCTCTCATGTATCATACCTGGAATGGGATCCGACACTTGATGTGGGACCTAGGA
AAAGGCCTGAAGATTCCCCAGCTATACCAGTCTGGAGTGGTTGTCCTGGTTCTTACTGTG
TTGTCCTCTATGGGGCTGGCAGCCATGTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
U57877

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_9_Locus:
1q21

# Metabolic_Enzyme_9_SNPs:
rs3935401; rs4600063; rs8266; rs16832859; rs4488054; rs9887965; rs9970904; rs4255402; rs9330294; rs4255403; rs4272646; rs16832813; rs10157093; rs4656297; rs12730813; rs4548462; rs4291521; rs12745115; rs4272644; rs4282845; rs4656296; rs4463689; rs12745476; rs4272643; rs4634927; rs4319356; rs11588994; rs11585941; rs4622080; rs7412460; rs16832854; rs12737323; rs16832810; rs6666989; rs4309000; rs6679543; rs16832850; rs13376158; rs4256831; rs13375385; rs12097837; rs4481873; rs11578160; rs16832849; rs16832847; rs10159083; rs16832826; rs16832820; rs7538701; rs16832809; rs16832823; rs16832842; rs4400628; rs4525064; rs17394957; rs4077290; rs12757174; rs7530775; rs16832846; rs4474277; rs4590682; rs12140361; rs16832808; rs16832851; rs11583870; rs16832811; rs7547940; rs4233369; rs16832824; rs11265589; rs35215598; rs16832817; rs12069801; rs4077289; rs16832835; rs4131826; rs17398689; rs4131825; rs11547238; rs36097930; rs11547241; rs3813632; rs34067216; rs35519301; rs5778206; rs16865495; rs35810451; rs35215727; rs34038974; rs34296822; rs12044212; rs35865051; rs35360738; rs9651051; rs34074635; rs34457815; rs16832845; rs34253350; rs35499684; rs6668201; rs12030219; rs12080348; rs4272645; rs34443836; rs36059328; rs12723403; rs12061542; rs11265592; rs34404220; rs35353173; rs34661906; rs11577663; rs35347070; rs6697518; rs5778205; rs34021120; rs4536024; rs34779243; rs6697729; rs35847646; rs34948810; rs4631719; rs11265591; rs35337467; rs34326743; rs11292581; rs34705544; rs4308999; rs35680024; rs35634816; rs4596919; rs34224160; rs34681478; rs35392949; rs5022335; rs12080455; rs4634926; rs35046931; rs35006684; rs35327704; rs35827977; rs12741391; rs12135397; rs11265590; rs34241833; rs4469725; rs11286351; rs12128072; rs9662590; rs36047860; rs35038284; rs12038724; rs7415671; rs34497174; rs34006306; rs12750496; rs34744926; rs35418568; rs34241519; rs4477296; rs35949692; rs34690479; rs34589411; rs36069694; rs35130144; rs16832814; rs34984327; rs12144150; rs4131827; rs34027852; rs35783795; rs35120880; rs11265588; rs34519315; rs35064604; rs35966414; rs10494350; rs10494351; rs10494352; rs10494353; rs10494354; rs11265587; rs1133805; rs1133806; rs11579939; rs12064957; rs12065184; rs12122313; rs12239492; rs12239719; rs12731474; rs13374037; rs16832786; rs16832790; rs16832793; rs16832801; rs16832869; rs16832871; rs16832872; rs16832874; rs16832883; rs16832884; rs16832887; rs16832892; rs16832894; rs16832897; rs16832900; rs17348095; rs17395595; rs17399583; rs34307129; rs3813630; rs3813631; rs4072409; rs6674383; rs6682046; rs6684273; rs7531561; rs7532602; rs7550839; rs7551761; rs7554208

# Metabolic_Enzyme_9_General_References:
9533030; 9714607; 11062460

# Metabolic_Enzyme_9_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7549

# Macromolecular_Interacting_Partner_1_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
INS

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_1_Signals:
1-24

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
INS

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11p15.5

# Macromolecular_Interacting_Partner_1_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_1_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_1_References:
15986240

# Macromolecular_Interacting_Partner_2_ID:
8212

# Macromolecular_Interacting_Partner_2_Name:
LIM domain-binding protein 3

# Macromolecular_Interacting_Partner_2_Synonyms:
Z-band alternatively spliced PDZ-motif protein; Protein cypher

# Macromolecular_Interacting_Partner_2_Gene_Name:
LDB3

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>LIM domainbinding protein 3
MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM
THLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAP
SPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDL
LGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPIKDLAVD
SASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSST
PIEHAPVCTSQATTPLLPASAQPPAAASPSAASPPLATAAAHTAIASASTTAPASSPADS
PRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSP
GANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGG
PAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAE
RFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCER
CYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKD
YINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKK
HAHTINL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
727

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
77135

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
8.20

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  protein binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Transcription 

# Macromolecular_Interacting_Partner_2_Specific_Function:
May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00412:LIM;
PF00595:PDZ

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
5441367

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
LDB3_HUMAN (O75112)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
LDB3

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
LDB3

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:15710

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cytoplasm; perinuclear region. Cell projection; pseudopodium. Note=Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>852 bp
ATGTCTTACAGTGTGACCCTGACTGGGCCCGGGCCCTGGGGCTTCCGTCTGCAGGGGGGC
AAGGACTTCAACATGCCCCTCACTATCTCCCGGATCACACCAGGCAGCAAGGCAGCCCAG
TCCCAGCTCAGCCAGGGTGACCTCGTGGTGGCCATTGACGGCGTCAACACAGACACCATG
ACCCACCTGGAAGCCCAGAACAAGATCAAGTCTGCCAGCTACAACTTGAGCCTCACCCTG
CAGAAATCAAAGCGTCCCATTCCCATCTCCACGACAGCACCTCCAGTCCAGACCCCTCTG
CCGGTGATCCCTCACCAGAAGGTGGTAGTCAACTCTCCAGCCAACGCCGACTACCAGGAA
CGCTTCAACCCCAGTGCCCTGAAGGACTCGGCCCTGTCCACCCACAAGCCCATCGAGGTG
AAGGGGCTGGGCGGCAAGGCCACCATCATCCATGCGCAGTACAACACGCCCATCAGCATG
TATTCCCAGGATGCCATCATGGATGCCATCGCTGGGCAGGCCCAAGCCCAAGGCAGTGAC
TTCAGTGGGAGCCTCCCTATTAAGGACCTTGCCGTAGACAGCGCCTCTCCCGTCTACCAG
GCTGTGATTAAGAGCCAGAACAAGCCAGAAGATGAGGCTGACGAGTGGGCACGCCGTTCC
TCCAACCTGCAGTCTCGCTCCTTCCGCATCCTGGCCCAGATGACGGGGACAGAATTCATG
CAAGACCCTGATGAAGAAGCTCTGCGAAGTCAAGGGAAAGGTTTGAAACGGAAACGTAAC
AGCCCACGTTTTGCCAAATTGCGCAACTGGCACCATGGCCTTTCAGCCCAAATCCTTAAT
GTTAAAAGCTAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AJ133766

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_2_Locus:
10q22.3-q23.2

# Macromolecular_Interacting_Partner_2_SNPs:
rs3740343; rs34218952; rs3802664; rs4468255; rs11202124; rs2803560; rs7086308; rs3740342; rs7092188; rs4934245; rs4934254; rs7916248; rs6586024; rs2248643; rs6586023; rs4934244; rs7908765; rs7085298; rs4934251; rs2803566; rs2803567; rs1578895; rs3802663; rs6586031; rs7069570; rs4462249; rs11593608; rs10788526; rs2675686; rs3802662; rs4408238; rs6586029; rs2354360; rs11202121; rs2803570; rs4934246; rs10887650; rs6586032; rs4556455; rs4278432; rs12244569; rs4525132; rs6586025; rs17335189; rs3740347; rs7899337; rs10887639; rs2354363; rs4620630; rs7899324; rs2675691; rs3740346; rs3740345; rs2248537; rs4933405; rs2247689; rs11812963; rs11202117; rs10788525; rs2248538; rs7099341; rs12569813; rs4934253; rs11599515; rs1986382; rs11594919; rs2803572; rs7894381; rs11202120; rs2803562; rs10788524; rs12244574; rs1986383; rs6586026; rs11595553; rs2675700; rs2354359; rs12251784; rs11202140; rs2354357; rs12260726; rs7086122; rs7895178; rs1806471; rs17426050; rs11819261; rs11202119; rs11202136; rs12221151; rs11202133; rs7475311; rs12414766; rs10887646; rs2803559; rs4934250; rs10887645; rs2803561; rs17106968; rs7908829; rs17106978; rs12263789; rs12258339; rs11202122; rs7088948; rs10887641; rs12240576; rs4492716; rs7075204; rs4933406; rs11202118; rs11814947; rs11597201; rs2354356; rs2244769; rs10887644; rs7893160; rs12251655; rs12570315; rs7923558; rs10749541; rs7074015; rs10887651; rs12254069; rs12770250; rs10788522; rs17335168; rs10887643; rs7918367; rs4934249; rs2803568; rs4934252; rs11202126; rs12220664; rs17106959; rs12570147; rs12268509; rs2803571; rs11202138; rs10887648; rs10788523; rs17106956; rs7909928; rs2803564; rs11202128; rs2354362; rs4934248; rs2354358; rs3740344; rs11592193; rs4933404; rs12251540; rs11202127; rs2354361; rs10887642; rs7079363; rs2803563; rs12265236; rs12414832; rs4934243; rs10887640; rs17106945; rs35569375; rs17426017; rs7910307; rs10887647; rs11815273; rs12415298; rs7908743; rs4256897; rs2675692; rs2675693; rs2803555; rs2803558; rs34499525; rs35777670; rs11812601; rs34959905; rs34073498; rs34346910; rs35507268; rs12761754; rs34423165; rs12761767; rs11277810; rs35222021; rs1129720; rs1140171; rs34120124; rs35309921; rs11295601; rs12771857; rs7476499; rs41306868; rs7090715; rs35869109; rs3740348; rs34836333; rs12241060; rs12251973; rs34158661; rs34407382; rs9325589; rs12267313; rs11202132; rs11312118; rs7476032; rs7067613; rs36034038; rs34555032; rs41284059; rs11816975; rs4934247; rs34886010; rs35422936; rs12218053; rs12218046; rs11596380; rs35348533; rs10636675; rs12777922; rs34393529; rs3086887; rs11202134; rs7897549; rs11294968; rs36008448; rs11394900; rs36082932; rs10573832; rs34552947; rs35644119; rs3204237; rs12359981; rs4933407; rs34677208; rs4611110; rs36037775; rs5786744; rs10600377; rs35075932; rs3204236; rs34609974; rs35443941; rs7350396; rs11202137; rs12771609; rs12217487; rs35496319; rs12570979; rs11331035; rs2675690; rs5786743; rs11202130; rs11813013; rs4934242; rs34215720; rs12773201; rs34010340; rs9794160; rs36035051; rs12220648; rs35038512; rs35036282; rs7080273; rs35548503; rs11422538; rs6586027; rs34941291; rs7901128; rs36003521; rs12243535; rs12219069; rs35158654; rs35076035; rs7907134; rs36086893; rs12240646; rs11202139; rs34544606; rs35171755; rs12219020; rs4934241; rs11202131; rs12248422; rs34295502; rs35394356; rs12262050; rs12259201; rs35543964; rs12251776; rs35305714; rs1140170; rs11594242; rs34647099; rs10664257; rs1962096; rs11271876; rs10562903; rs36202103; rs11202135; rs11202129; rs11306108; rs35605324; rs12773445; rs12220339; rs12773033; rs7921989; rs7088351; rs4934240; rs2803557; rs34339902; rs2803556; rs35593937; rs34972863; rs34432919; rs11314847; rs36073042; rs35584371; rs1079610; rs11202110; rs11202111; rs11202113; rs11202142; rs1125774; rs11594957; rs12220083; rs12244985; rs12252834; rs12261055; rs12262894; rs12763142; rs17425122; rs17425484; rs2014077; rs2014084; rs2254548; rs2675694; rs2675695; rs2675696; rs2675697; rs2675698; rs2736687; rs2803550; rs2803551; rs2803553; rs2803554; rs33921909; rs33936589; rs34088875; rs35264027; rs35357978; rs36064638; rs3740332; rs3740335; rs3740337; rs3740340; rs3740341; rs3924093; rs4244972; rs4394749; rs4934255; rs4934256; rs7069417; rs7086492; rs7478092; rs7911340; rs7917572; rs909285

# Macromolecular_Interacting_Partner_2_General_References:
10427098; 9734811; 11842093

# Macromolecular_Interacting_Partner_2_References:
15319808

End of HMDB00176

Beginning of HMDB00177
# Accession_No:
HMDB00177

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-19 11:18:20

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
L-Histidine

# Description:
Histidine is an essential amino acid for infants but not adults. Infants four to six months old require 33 mg/kg of histidine. It is not clear how adults make small amounts of histidine, and dietary sources probably account for most of the histidine in the body. Inborn errors of histidine metabolism exist and are marked by increased histidine levels in the blood. Elevated blood histidine is accompanied by a wide range of symptoms, from mental and physical retardation to poor intellectual functioning, emotional instability, tremor, ataxia and psychosis. Histidine in medical therapies has its most promising trials in rheumatoid arthritis where up to 4.5 g daily have been used effectively in severely affected patients. Arthritis patients have been found to have low serum histidine levels, apparently because of too-rapid removal of histidine from their blood. Histidine and other imidazole compounds have anti-inflammatory properties. Histidine may accomplish this function through a complex interaction with threonine or cysteine and possibly copper. However, copper is usually elevated in rheumatoid arthritis patients and worsens the disease. Other patients besides arthritis patients that have been found to be low in serum histidine are those with chronic renal failure. Histidine has been claimed to have been useful in hypertension because of its vasodilatory effects. Claims of its use to improve libido and counteract allergy are without proof at present. Histidine may have many other possible functions because it is the precursor of the ubiquitous neurohormone-neurotransmitter histamine. Histidine increases histamine in the blood and probably in the brain. Low blood histamine with low serum histidine occurs in rheumatoid arthritis patients. Low blood histamine also occurs in some manic, schizophrenic, high copper and hyperactive groups of psychiatric patients. Histidine is a useful therapy in all low histamine patients. (http://www.dcnutrition.com)

# Synonyms:
(S)-1H-Imidazole-4-alanine; (S)-2-Amino-3-(4-imidazolyl)propionsaeure; (S)-4-(2-Amino-2-carboxyethyl)imidazole; (S)-Histidine; (S)-a-Amino-1H-imidazole-4-propanoate; (S)-a-Amino-1H-imidazole-4-propanoic acid; (S)-alpha-Amino-1H-imidazole-4-propanoate; (S)-alpha-Amino-1H-imidazole-4-propanoic acid; (S)-alpha-Amino-1H-imidazole-4-propionate; (S)-alpha-Amino-1H-imidazole-4-propionic acid; (S)1H-Imidazole-4-alanine; 3-(1H-imidazol-4-yl)-L-Alanine; Glyoxaline-5-alanine; His; Histidine; L-(-)-Histidine; amino-1H-imidazole-4-propanoate; amino-1H-imidazole-4-propanoic acid; amino-4-imidazoleproprionate; amino-4-imidazoleproprionic acid

# Chemical_IUPAC_Name:
2-amino-3-(3H-imidazol-4-yl)propanoic acid

# Chemical_Formula:
C6H9N3O2

# Chemical_Structure:
tbl_chemical:::HMDB00177_ZOOM.png:::119283236326482875

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00177_THUMB.png:::119283236165364874

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid; aromatic compound; heterocyclic compound; alpha-aminoacid

# Taxonomy_Biofunction:
Essential amino acids; semi-essential amino acids; Essential amino acid; Component of Aminoacyl-tRNA biosynthesis; Component of Histidine metabolism; Component of Nitrogen metabolism

# Taxonomy_Source:
Exogenous

# Molecular_Weight:
155.06949

# Molecular_Weight_Avg:
155.15456

# Smiles_String_isomeric:
N[C@@H](CC1=CNC=N1)C(O)=O

# Smiles_String_canonical:
NC(CC1=CNC=N1)C(O)=O

# KEGG_Compound_ID:
C00135

# BioCyc_ID:
HIS

# PubChem_CID:
6274

# PubChem_SID:
8023160; 10533543; 7847100; 8023165; 8028518; 11108714; 834180; 819143; 824156; 854870; 8023119; 6436078; 8153954; 8145060; 8023163; 822008; 825523; 3136567; 3435; 822081; 587554; 609693; 854862; 149204; 11111281; 207332; 7854202

# OMIM_ID:
235800; 235830; 305900

# Metagene_ID:
Not Available.

# BiGG_ID:
33985

# Wikipedia_ID:
L-Histidine

# METLIN_ID:
21

# Ref_ID:
4064282; 15911239; 12297216; 14992292; 15933069; 1253070; 7729054; 15927833; 12097436; 2026685; 15928846; 11237944; 6696735; 15929169; 15924420; 1547771; 6198473

# ChEBI_ID:
15971

# CAS_Registry_Number:
71-00-1

# InChI:
InChI=1/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

# Synthesis_Reference:
Chemical & Pharmaceutical Bulletin  (1987),  35(8),  3447-52.

# Melting_Point:
287 oC

# Melting_Point_predicted:
92.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
45.6 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
71.3 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-3.32 [CHMELIK,J ET AL. (1991)]

# LogP_predicted:
-2.66 [Predicted by ALOGPS]; -3.4 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::L-Histidine.pdf:::1132562211906893029

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::L-Histidine.mol:::1132723812296248949

# SDF_File_[Text]:
tbl_chemical:::HMDB00177.sdf:::119283235856443080

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00177.pdb:::119283236028728493

# PDB_ID:
1KAH

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041019_P00_01_HW_1DP_presat.png:::116129357512081153

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041019_P00_01_HW_1DP_presat.zip:::115109499527683722

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041019_P00_01_HW_1DP_Assigned.png:::115687026637041447

# C_NMR_Spectra:
tbl_cnmr:::041019_P00_01_HW_1DC_27.jpg:::114168459990613853

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041019_P00_01_HW_1DC_27.zip:::114168459986340681

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041019_P00_01_HW_1DC_27_Assigned.jpg:::114332833239476070

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041019_P00_01_HW_2DHSQC_19.jpg:::114496206559335881

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041019_P00_01_HW_2DHSQC_19.zip:::114496206628112254

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041019_P00_01_HW_2DHSQC_19_Assigned.jpg:::11449620664521181

# Predicted_H_NMR_Spectrum:
tbl_chemical:::L-Histidine.gif:::1132732118859458760

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00177_peaks.txt:::1156309599057368902

# Predicted_C_NMR_Spectrum:
tbl_chemical:::L-Histidine_C.gif:::1132737712697711547

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00177_peaks.txt:::1156310788427230953

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00177L.png:::11755526271607477; Medium Energy:tbl_ms:::HMDB00177M.png:::117555268095147257; High Energy:tbl_ms:::HMDB00177H.png:::11755527152185963

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; Extracellular

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Urine	87.2 (23.0-151.0)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Blood	75.0 +/- 20.0	umol/L	Newborn:0-30_days_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	86.0 +/- 10.0	umol/L	Children:1-13_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	89.0 +/- 11.0	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	83.0 +/- 14.0	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	82.0 (72.0-92.0)	umol/L	Adult:>18_yrs_old	Both	Normal	12297216
Cerebrospinal_Fluid(CSF)	20.7 +/- 7.5	umol/L	Adult:>18_yrs_old	N/A	Normal	15911239
Cerebrospinal_Fluid(CSF)	16.8 +/- 2.7	umol/L	Adult:>18_yrs_old	Male	Normal	6198473
Cerebrospinal_Fluid(CSF)	18.6 +/- 3.3	umol/L	Adult:>18_yrs_old	Female	Normal	6198473
Cerebrospinal_Fluid(CSF)	10.9 (10.4-11.4)	umol/L	Adult:>18_yrs_old	Both	Normal	14992292
Cerebrospinal_Fluid(CSF)	11.9 +/- 1.7	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Saliva	>10	umol/L	Adult:>18_yrs_old	Both	Normal	12097436


# Concentration_[Abnormal]:
Blood	67.0 (64.0-70.0)	umol/L	Adult:>18_yrs_old	Both	Dengue	11237944
Blood	70.0	umol/L	Adult:>18_yrs_old	Both	Diabetes	6696735
Blood	80.5 (76.3-84.7)	umol/L	Adult:>18_yrs_old	Both	Acute seizures	14992292
Blood	107.0 (101.0-114.0)	umol/L	Adult:>18_yrs_old	Both	Refractory localization-related epilepsy (RLE)	14992292
Cerebrospinal_Fluid(CSF)	21.4 +/- 6.6	umol/L	N/A	N/A	leukemia	15911239
Cerebrospinal_Fluid(CSF)	10.3 +/- 3.7	umol/L	N/A	N/A	leukemia with CNS disease	15911239
Cerebrospinal_Fluid(CSF)	130.0	umol/L	Adult:>18_yrs_old	Both	Histidinemia	7729054


# Associated_Disorders:
Acute seizures; Dengue; Diabetes; Histidinemia; Juvenile Myoclonic Epilepsy (JME); leukemia; leukemia with CNS disease; Refractory Localization-Related Epilepsy (RLE)

# Pathway_Names:
Not Available

# Pathway_Images:
Not Available

# KEGG_Images:
Not Available

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5914

# Metabolic_Enzyme_1_Name:
Probable histidyl-tRNA synthetase, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
Histidine--tRNA ligase; HisRS; Histidine--tRNA ligase-like

# Metabolic_Enzyme_1_Gene_Name:
HARSL

# Metabolic_Enzyme_1_Protein_Sequence:
>Probable histidyltRNA synthetase, mitochondrial precursor
MPLLGLLPRRAWASLLSQLLRPPCASCTGAVRCQSQVAEAVLTSQLKAHQEKPNFIIKTP
KGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGLMYDLKD
QGGELLSLRYDLTVPFARYLAMNKVKKMKRYHVGKVWRRESPTIVQGRYREFCQCDFDIA
GQFDPMIPDAECLKIMCEILSGLQLGDFLIKVNDRRIVDGMFAVCGVPESKFRAICSSID
KLDKMAWKDVRHEMVVKKGLAPEVADRIGDYVQCHGGVSLVEQMFQDPRLSQNKQALEGL
GDLKLLFEYLTLFGIADKISFDLSLARGLDYYTGVIYEAVLLQTPTQAGEEPLNVGSVAA
GGRYDGLVGMFDPKGHKVPCVGLSIGVERIFYIVEQRMKTKGEKVRTTETQVFVATPQKN
FLQERLKLIAELWDSGIKAEMLYKNNPKLLTQLHYCESTGIPLVVIIGEQELKEGVIKIR
SVASREEVAIKRENFVAEIQKRLSES

# Metabolic_Enzyme_1_Number_of_Residues:
506

# Metabolic_Enzyme_1_Molecular_Weight:
56889

# Metabolic_Enzyme_1_Theoretical_pI:
8.35

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  histidine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  histidyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  protein biosynthesis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_1_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_1_Specific_Function:
ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)

# Metabolic_Enzyme_1_Pathway:
map00340  Histidine metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_1_Reaction:
ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF03129:HGTP_anticodon;
PF00587:tRNA-synt_2b

# Metabolic_Enzyme_1_Signals:
1-13

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 6.1.1.21

# Metabolic_Enzyme_1_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_1_SwissProt_ID:
SYHM_HUMAN (P49590)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
HARSL

# Metabolic_Enzyme_1_Geneatlas_id:
HARSL

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4817

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_1_Gene_Sequence:
Not Available

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U18936

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_1_Locus:
5q31.3

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
7755634

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6167

# Metabolic_Enzyme_2_Name:
Histidine decarboxylase

# Metabolic_Enzyme_2_Synonyms:
HDC

# Metabolic_Enzyme_2_Gene_Name:
HDC

# Metabolic_Enzyme_2_Protein_Sequence:
>Histidine decarboxylase
MMEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGD
IERIIMPGVV
HWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNV
MDWLAKMLGLPEHFLHHHPSS
QGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADE
SCLNARLVAYASDQAHSSVEKAGLISLVKMKF
LPVDDNFSLRGEALQKAIEEDKQRGLV
PVFVCATLGTTGVCAFDCLSELGPICAREGLWLHIDAAYAGTA
FLCPEFRGFLKGIEYA
DSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDFMHWQ
IPLSR
RFRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKG
PNCLT
ENVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAATLI
LSQHCTSQPSPRVGNL
ISQIRGARAWACGTSLQSVSGAGDDPVQARKIIKQPQRVGAGP
MKRENGLHLETLLDPVDDCFSEEAPDA
TKHKLSSFLFSYLSVQTKKKTVRSLSCNSVPV
SAQKPLPTEASVKNGGSSRVRIFSRFPEDMMMLKKSAF
KKLIKFYSVPSFPECSSQCGL
QLPCCPLQAMV

# Metabolic_Enzyme_2_Number_of_Residues:
662

# Metabolic_Enzyme_2_Molecular_Weight:
74141

# Metabolic_Enzyme_2_Theoretical_pI:
8.06

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
 ||
>>>
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
L-histidine = histamine + CO(2)

# Metabolic_Enzyme_2_Pathway:
map00340  Histidine metabolism

# Metabolic_Enzyme_2_Reaction:
L-histidine = histamine + CO2

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00282:Pyridoxal_deC

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 4.1.1.22

# Metabolic_Enzyme_2_GenBank_ID_Protein:
32109

# Metabolic_Enzyme_2_SwissProt_ID:
DCHS_HUMAN (P19113)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
HDC

# Metabolic_Enzyme_2_Geneatlas_id:
HDC

# Metabolic_Enzyme_2_hgnc_id:
HGNC:4855

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>1989 bp

ATGATGGAGCCTGAGGAGTACAGAGAGAGAGGGAGAGAGATGGTGGATTACATCTGCCA
GTACCTGAGCA
CTGTGCGGGAGAGACGTGTGACGCCAGACGTGCAGCCTGGCTACCTGC
GAGCCCAGCTGCCTGAGAGTGC
TCCTGAGGACCCCGACAGCTGGGACAGCATCTTTGGG
GACATTGAACGAATCATCATGCCTGGGGTGGTA
CATTGGCAGAGCCCCCATATGCACGC
CTACTACCCAGCCCTCACCTCTTGGCCCTCCCTGCTAGGAGACA
TGCTGGCTGATGCCA
TCAACTGCTTGGGATTCACCTGGGCATCCAGCCCTGCGTGTACAGAGCTGGAGAT
GAAC
GTCATGGACTGGTTGGCAAAAATGCTGGGACTTCCAGAGCACTTCTTGCACCACCACCCC
AGCAGC
CAGGGCGGAGGCGTCCTGCAGCAGACGGTCAGTGAATCCACTTTGATTGCCCT
GCTGGCAGCAAGGAAGA
ACAAAATCCTGGAAATGAAAACGTCTGAGCCCGATGCTGATG
AGTCCTGCCTAAATGCCCGACTCGTGGC
CTATGCCTCTGACCAGGCTCACTCCTCTGTG
GAAAAGGCTGGTTTGATTTCCCTTGTGAAGATGAAATTT
CTGCCTGTGGATGACAACTT
CTCACTCCGAGGGGAAGCTCTTCAGAAGGCCATCGAGGAAGACAAGCAGC
GGGGCTTGG
TGCCCGTCTTTGTCTGTGCAACACTAGGGACCACTGGGGTCTGTGCATTTGACTGCCTGT
C
AGAGCTGGGCCCCATCTGTGCCCGTGAGGGGCTGTGGCTCCACATCGATGCTGCTTAT
GCAGGCACTGCC
TTCCTGTGCCCCGAGTTCCGGGGGTTTCTGAAGGGGATTGAGTATGC
CGACTCCTTCACCTTTAATCCTT
CCAAGTGGATGATGGTGCATTTTGACTGTACTGGGT
TCTGGGTCAAGGACAAGTACAAGCTGCAGCAGAC
CTTCAGTGTGAATCCCATCTACCTC
AGGCATGCCAACTCAGGCGTGGCCACCGACTTCATGCACTGGCAG
ATCCCCCTGAGCCG
ACGGTTTCGCTCTGTTAAACTCTGGTTCGTGATTCGGTCCTTCGGGGTGAAGAATC
TTC
AAGCACATGTCAGACATGGTACTGAAATGGCTAAATATTTTGAATCTCTGGTCAGAAACG
ACCCTTC
CTTTGAAATTCCTGCCAAGAGGCACCTTGGCCTGGTGGTTTTTCGTCTAAAG
GGTCCTAATTGTCTCACA
GAAAATGTGTTAAAGGAAATAGCTAAAGCTGGCCGTCTCTT
CCTCATCCCGGCCACTATCCAGGACAAGT
TAATCATCCGTTTCACTGTGACATCCCAGT
TTACCACTAGGGATGACATCCTGAGAGACTGGAATCTCAT
TCGAGATGCTGCCACTCTC
ATCCTGAGTCAGCACTGTACTTCCCAACCCAGCCCTCGGGTTGGGAACCTC
ATCTCCCA
AATCAGGGGTGCCAGAGCCTGGGCCTGTGGAACGTCCCTTCAGTCTGTCAGTGGGGCAGG
AG
ATGATCCAGTCCAGGCCAGGAAGATCATCAAGCAGCCTCAGCGTGTGGGAGCCGGTC
CCATGAAAAGGGA
AAATGGCCTCCATCTTGAAACCCTGCTGGACCCAGTTGATGACTGC
TTTTCAGAAGAGGCCCCAGATGCC
ACCAAGCACAAGCTGTCCTCCTTCCTGTTCAGTTA
CTTGTCTGTGCAGACTAAGAAGAAGACGGTGCGCT
CCCTCAGTTGCAACAGTGTGCCAG
TGAGTGCTCAGAAGCCACTGCCCACAGAGGCCTCTGTGAAGAATGG
GGGCTCCTCCAGG
GTCAGAATCTTTTCCAGGTTTCCAGAAGACATGATGATGCTGAAGAAAAGTGCCTTC
AA
AAAACTCATCAAATTCTACAGCGTCCCCAGCTTTCCTGAATGCAGCTCTCAATGTGGACT
CCAGCTGC
CCTGTTGCCCTCTGCAGGCCATGGTTTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X54297

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_2_Locus:
15q21-q22

# Metabolic_Enzyme_2_SNPs:
rs2073440; rs16963486; rs17740607; rs1549521; rs35670478; rs16963485; rs1042447; rs16963481; rs854151; rs860526; rs854158; rs854160; rs7164386; rs2070595; rs854159; rs854150; rs1894236; rs854157; rs7182203; rs8029889; rs854153; rs16963496; rs2070596; rs854155; rs2238294; rs10518836; rs2853766; rs854152; rs854163; rs11856059; rs552379; rs3784295; rs16963517; rs2238292; rs854154; rs7163895; rs11857173; rs8042671; rs16963519; rs17740669; rs2081629; rs16963523; rs7163360; rs16963493; rs16963514; rs17796788; rs12437691; rs16963498; rs1793854; rs854149; rs854164; rs7167784; rs7166052; rs6493424; rs8028354; rs854165; rs7167126; rs7183971; rs9920752; rs7168181; rs7166426; rs7166844; rs34505468; rs34406040; rs35806322; rs28575044; rs34287511; rs28458934; rs35232486; rs7165554; rs854161; rs10565294; rs854162; rs854156; rs11400557; rs28709471; rs1793853; rs35640167; rs36092412; rs28707431; rs1793856; rs2283429; rs28591129; rs28715273; rs28549390; rs9796729; rs35437083; rs28564355; rs1573594; rs8029272; rs35793877; rs28758988; rs2238295; rs11418562; rs9920723; rs11274787; rs854166; rs7166950; rs491656; rs35047996; rs491658; rs35490626; rs10220755; rs10519263; rs10519264; rs12438041; rs12591371; rs12901373; rs13329426; rs13329489; rs13329494; rs1365503; rs1529341; rs1529343; rs1529344; rs16963459; rs16963464; rs16963474; rs16963477; rs17848313; rs1802536; rs1802537; rs2114446; rs2114447; rs2187576; rs34984126; rs3959666; rs7162842; rs7163191; rs8029462; rs8030902; rs8034597; rs9920008; rs9920021

# Metabolic_Enzyme_2_General_References:
2216786; 1768863; 1425659; 8288622

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5956

# Metabolic_Enzyme_3_Name:
Histidine ammonia-lyase

# Metabolic_Enzyme_3_Synonyms:
Histidase

# Metabolic_Enzyme_3_Gene_Name:
HAL

# Metabolic_Enzyme_3_Protein_Sequence:
>Histidine ammonialyase
MPRYTVHVRGEWLAVPCQDAQLTVGWLGREAVRRYIKNKPDNGGFTSVDDAHFLVRRCKG
LGLLDNEDRLEVALENNEFVEVVIEGDAMSPDFIPSQPEGVYLYSKYREPEKYIELDGDR
LTTEDLVNLGKGRYKIKLTPTAEKRVQKSREVIDSIIKEKTVVYGITTGFGKFARTVIPI
NKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIEMFNAS
CLPYVPEKGTVGASGDLAPLSHLALGLVGEGKMWSPKSGWADAKYVLEAHGLKPVILKPK
EGLALINGTQMITSLGCEAVERASAIARQADIVAALTLEVLKGTTKAFDTDIHALRPHRG
QIEVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKNIITT
ELNSATDNPMVFANRGETVSGGNFHGEYPAKALDYLAIGIHELAAISERRIERLCNPSLS
ELPAFLVAEGGLNSGFMIAHCTAAALVSENKALCHPSSVDSLSTSAATEDHVSMGGWAAR
KALRVIEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDI
EAAHRLLLEQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLQFLHKKSTKIPESEDL

# Metabolic_Enzyme_3_Number_of_Residues:
657

# Metabolic_Enzyme_3_Molecular_Weight:
72698

# Metabolic_Enzyme_3_Theoretical_pI:
6.95

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  acid-ammonia (or amide) ligase activity
Function:  ammonia ligase activity
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-nitrogen lyase activity
Function:  ammonia-lyase activity
Function:  histidine ammonia-lyase activity
 ||
>>>
Process:  biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  histidine family amino acid metabolism
Process:  histidine metabolism
Process:  histidine catabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_3_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
L-histidine = urocanate + NH(3)

# Metabolic_Enzyme_3_Pathway:
map00340  Histidine metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_3_Reaction:
L-histidine = urocanate + NH3

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00221:PAL

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 4.3.1.3

# Metabolic_Enzyme_3_GenBank_ID_Protein:
451210

# Metabolic_Enzyme_3_SwissProt_ID:
HUTH_HUMAN (P42357)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
HAL

# Metabolic_Enzyme_3_Geneatlas_id:
HAL

# Metabolic_Enzyme_3_hgnc_id:
HGNC:4806

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>1974 bp
ATGCCCAGATACACGGTGCACGTACGTGGGGAATGGCTGGCAGTGCCCTGCCAGGACGCG
CAGCTCACTGTGGGCTGGCTGGGCCGGGAGGCCGTGAGGCGCTATATCAAGAATAAGCCC
GACAATGGTGGCTTCACCTCCGTGGATGACGCGCACTTCCTTGTGCGCCGGTGCAAGGGC
CTGGGCCTGCTGGACAACGAGGACCGGCTCGAGGTGGCCCTAGAGAACAACGAGTTCGTG
GAAGTGGTTATAGAGGGTGATGCCATGTCTCCTGACTTCATTCCATCTCAACCAGAAGGA
GTTTATCTATACAGCAAGTACCGGGAGCCTGAAAAGTACATCGAGTTAGATGGAGACCGT
CTGACCACGGAGGATCTGGTCAACTTGGGAAAGGGACGCTACAAAATAAAGCTCACCCCA
ACAGCTGAGAAGAGGGTGCAGAAATCCAGGGAGGTCATAGATAGCATCATAAAAGAGAAA
ACAGTTGTTTACGGTATTACTACAGGTTTTGGGAAATTTGCCAGAACTGTAATTCCTATC
AATAAGCTACAGGAGCTTCAGGTCAACTTAGTACGCTCACATTCTTCAGGTGTTGGGAAA
CCACTAAGTCCTGAGAGGTGTCGGATGCTCTTGGCTTTAAGGATCAATGTCTTAGCCAAA
GGATACAGTGGCATTTCCCTGGAGACCCTCAAACAAGTCATAGAAATGTTTAATGCCTCC
TGCCTGCCCTATGTCCCAGAGAAAGGAACCGTTGGTGCCAGTGGAGACCTTGCCCCACTC
TCTCATCTTGCTCTTGGGCTAGTTGGAGAAGGGAAGATGTGGTCTCCGAAGAGTGGCTGG
GCTGATGCTAAATACGTGCTAGAAGCCCATGGATTGAAACCAGTTATTTTAAAACCAAAA
GAGGGCCTGGCACTCATCAATGGGACGCAGATGATCACATCCCTGGGCTGTGAAGCTGTA
GAGCGAGCCAGTGCTATTGCACGGCAGGCTGACATTGTGGCAGCCCTGACCCTTGAGGTG
CTGAAGGGCACCACCAAAGCCTTTGACACTGACATTCATGCTCTTCGACCTCACCGTGGG
CAAATTGAAGTTGCTTTTCGGTTTCGGTCACTCTTGGACTCAGATCACCACCCATCAGAA
ATAGCAGAGAGTCACAGGTTCTGTGATCGCGTCCAGGATGCATACACCTTGCGCTGCTGT
CCACAGGTCCATGGTGTGGTGAATGATACAATAGCATTTGTGAAGAACATCATTACCACA
GAACTGAACAGCGCAACAGATAATCCTATGGTCTTTGCCAATAGGGGAGAGACAGTTTCT
GGAGGAAACTTCCATGGTGAATACCCAGCCAAAGCCCTAGACTACTTGGCCATTGGCATC
CATGAACTTGCTGCAATCAGTGAGAGAAGAATCGAGCGGCTCTGCAATCCCTCCCTCAGT
GAGCTGCCTGCCTTCCTGGTGGCTGAAGGTGGTCTGAACTCTGGGTTCATGATAGCTCAC
TGCACGGCAGCAGCCCTTGTTTCTGAGAACAAGGCTCTGTGCCATCCCTCGTCTGTTGAC
TCCCTCTCCACCAGCGCAGCCACGGAGGACCACGTCTCCATGGGAGGATGGGCAGCAAGG
AAAGCCCTCAGGGTCATCGAGCATGTGGAGCAAGTGCTGGCCATCGAGCTCCTTGCAGCC
TGCCAGGGCATAGAGTTTCTACGTCCCCTGAAAACAACCACTCCGCTGGAGAAGGTCTAT
GACCTGGTGCGCTCTGTTGTAAGGCCCTGGATAAAAGATCGCTTCATGGCCCCGGACATC
GAGGCAGCCCACAGGCTGCTCCTGGAGCAGAAGGTTTGGGAAGTAGCTGCTCCATACATT
GAAAAATACAGAATGGAGCATATTCCAGAATCAAGACCTCTTTCTCCAACAGCCTTTTCA
CTGCAATTTCTGCACAAGAAATCCACCAAAATCCCGGAGTCTGAGGACCTTTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
D16626

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_3_Locus:
12q22-q24.1

# Metabolic_Enzyme_3_SNPs:
rs7297245; rs17024973; rs2302628; rs11108364; rs36014288; rs2230885; rs11108369; rs2268520; rs2302629; rs2268518; rs10859996; rs11108366; rs2072511; rs2268517; rs3764038; rs11108368; rs2300560; rs3819817; rs10745747; rs2241136; rs3213737; rs10492227; rs10859995; rs7308827; rs17024981; rs17024935; rs7310419; rs12301817; rs2268519; rs2270318; rs17676826; rs10492228; rs10859997; rs17024956; rs7316786; rs11108356; rs12298414; rs721199; rs11108365; rs4762264; rs10745746; rs10777763; rs12318681; rs11108360; rs17024962; rs2068662; rs17024986; rs6538696; rs7133811; rs7966537; rs17676451; rs4762263; rs17024995; rs12427251; rs12319274; rs4762262; rs7308844; rs7137420; rs7136523; rs12307364; rs17024937; rs11108361; rs11108359; rs17677007; rs3741815; rs17733203; rs10859998; rs2241137; rs10777764; rs7308555; rs7136852; rs2070614; rs1059845; rs1059844; rs7134860; rs7970524; rs7134975; rs10859999; rs3829305; rs11835389; rs7956014; rs10777762; rs11108371; rs11108370; rs7306086; rs34457757; rs35643296; rs34268157; rs34541335; rs7304917; rs4418880; rs34738482; rs11108363; rs10708992; rs12814960; rs2287056; rs6538693; rs34148511; rs35249157; rs6538694; rs4451792; rs4595631; rs4762659; rs34975193; rs34466661; rs35532808; rs2270317; rs12810515; rs12809145; rs2287055; rs11108358; rs12298212; rs35351448; rs1108405; rs6538695; rs4995764; rs7137747; rs11108362; rs3214368; rs35963926; rs11108357; rs11108367; rs35777937; rs3764037; rs12297099; rs34515139; rs11454735; rs2287057; rs36054506; rs4995766; rs35144639; rs35152917; rs12810520; rs35559744; rs4995765; rs12822785; rs12809482; rs12297102; rs12309712; rs12298680; rs4325387; rs10537373; rs7975900; rs34539324; rs12310543; rs12824794; rs3812807; rs12231580; rs12826052; rs12826051; rs34149011; rs12231566; rs12826042; rs12826043; rs12231565; rs7976204; rs12826048; rs12826049; rs34600440; rs1025606; rs1025607; rs1025608; rs10507068; rs10507069; rs1050970; rs10777757; rs11108355; rs11108372; rs11108373; rs11613777; rs11614411; rs11826; rs11837995; rs12302993; rs12322336; rs12581429; rs17024904; rs17024908; rs17025016; rs17025023; rs17025026; rs17025028; rs17677343; rs1803916; rs2540499; rs2540500; rs4762258; rs4762657; rs4762658; rs5020450; rs7486464; rs7963056; rs7975895; rs7976105; rs7976535

# Metabolic_Enzyme_3_General_References:
7916645; 8530107

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5713

# Metabolic_Enzyme_4_Name:
Beta-Ala-His dipeptidase precursor

# Metabolic_Enzyme_4_Synonyms:
Carnosine dipeptidase 1; CNDP dipeptidase 1; Serum carnosinase; Glutamate carboxypeptidase-like protein 2

# Metabolic_Enzyme_4_Gene_Name:
CNDP1

# Metabolic_Enzyme_4_Protein_Sequence:
>BetaAlaHis dipeptidase precursor
MDPKLGRMAASLLAVLLLLLERGMFSSPSPPPALLEKVFQYIDLHQDEFVQTLKEWVAIE
SDSVQPVPRFRQELFRMMAVAADTLQRLGARVASVDMGPQQLPDGQSLPIPPVILAELGS
DPTKGTVCFYGHLDVQPADRGDGWLTDPYVLTEVDGKLYGRGATDNKGPVLAWINAVSAF
RALEQDLPVNIKFIIEGMEEAGSVALEELVEKEKDRFFSGVDYIVISDNLWISQRKPAIT
YGTRGNSYFMVEVKCRDQDFHSGTFGGILHEPMADLVALLGSLVDSSGHILVPGIYDEVV
PLTEEEINTYKAIHLDLEEYRNSSRVEKFLFDTKEEILMHLWRYPSLSIHGIEGAFDEPG
TKTVIPGRVIGKFSIRLVPHMNVSAVEKQVTRHLEDVFSKRNSSNKMVVSMTLGLHPWIA
NIDDTQYLAAKRAIRTVFGTEPDMIRDGSTIPIAKMFQEIVHKSVVLIPLGAVDDGEHSQ
NEKINRWNYIEGTKLFAAFFLEMAQLH

# Metabolic_Enzyme_4_Number_of_Residues:
507

# Metabolic_Enzyme_4_Molecular_Weight:
56693

# Metabolic_Enzyme_4_Theoretical_pI:
4.95

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  protein dimerization activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  metallopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_4_Pathway:
map00340  Histidine metabolism;
 map00410  beta-Alanine metabolism

# Metabolic_Enzyme_4_Reaction:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF07687:M20_dimer;
PF01546:Peptidase_M20

# Metabolic_Enzyme_4_Signals:
1-26

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.4.13.20

# Metabolic_Enzyme_4_GenBank_ID_Protein:
16555792

# Metabolic_Enzyme_4_SwissProt_ID:
CNDP1_HUMAN (Q96KN2)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CNDP1

# Metabolic_Enzyme_4_Geneatlas_id:
CNDP1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:20675

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_4_Gene_Sequence:
>1527 bp
ATGGATCCCAAACTCGGGAGAATGGCTGCGTCCCTGCTGGCTGTGCTGCTGCTGCTGCTG
CTGGAGCGCGGCATGTTCTCCTCACCCTCCCCGCCCCCGGCGCTGTTAGAGAAAGTCTTC
CAGTACATTGACCTCCATCAGGATGAATTTGTGCAGACGCTGAAGGAGTGGGTGGCCATC
GAGAGCGACTCTGTCCAGCCTGTGCCTCGCTTCAGACAAGAGCTCTTCAGAATGATGGCC
GTGGCTGCGGACACGCTGCAGCGCCTGGGGGCCCGTGTGGCCTCGGTGGACATGGGTCCT
CAGCAGCTGCCCGATGGTCAGAGTCTTCCAATACCTCCCGTCATCCTGGCCGAACTGGGG
AGCGATCCCACGAAAGGCACCGTGTGCTTCTACGGCCACTTGGACGTGCAGCCTGCTGAC
CGGGGCGATGGGTGGCTCACGGACCCCTATGTGCTGACGGAGGTAGGCGGGAAACTTTAT
GGACGAGGAGCGACCGACAACAAAGGCCCTGTCTTGGCTTGGATCAATGCTGTGAGCGCC
TTCAGAGCCCTGGAGCAAGATCTTCCTGTGAATATCAAATTCATCATTGAGGGGATGGAA
GAGGCTGGCTCTGTTGCCCTGGAGGAACTTGTGGAAAAAGAAAAGGACCGATTCTTCTCT
GGTGTGGACTACATTGTAATTTCAGATAACCTGTGGATCAGCCAAAGGAAGCTAGCAATC
ACTTACGGAACCCGGGGGAACAGCTACTTCATGGTGGAGGTGAAATGCAGAGACCAGGAT
TTTCACTCAGGAACCTTTGGTGGCATCCTTCATGAACTAATGGCTGATCTGGTTGCTCTT
CTCGGTAGCCTGGTAGACTCGTCTGGTCATATCCTGGTCCCTGGAATCTATGATGAAGTG
GTTCCTCTTACAGAAGAGGAAATAAATACATACAAAGCCATCCATCTAGACCTAGAAGAA
TACCGGAATAGCAGCCGGGTTGAGAAATTTCTGTTCGATACTAAGGAGGAGATTCTAATG
CACCTCTGGAGGTACCCATCTCTTTCTATTCATGGGATCGAGGGCGCGTTTGATGAGCCT
GGAACTAAAACAGTCATACCTGGCCGAGTTATAGGAAAATTTTCAATCCGTCTAGTCCCT
CACATGAATGTGTCTGCGGTGGAAAAACAGGTGACACGACATCTTGAAGATGTGTTCTCC
AAAAGAAATAGTTCCAACAAGATGGTTGTTTCCATGACTCTAGGACTACACCCGTGGATT
GCAAATATTGATGACACTCAGTATCTCGCAGCAAAAAGAGCGATCAGAACAGTGTTTGGA
ACAGAACCAGATATGATCCGGGATGGATCCACCATTCCAATTGCCAAAATGTTCCAGGAG
ATCGTCCACAAGAGCGTGGTGCTAATTCCGCTGGGAGCTGTTGATGATGGAGAACATTCG
CAGAATGAGAAAATCAACAGGTGGAACTACATAGAGGGAACCAAATTATTTGCTGCCTTT
TTCTTAGAGATGGCCCAGCTCCATTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AJ417564

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:18

# Metabolic_Enzyme_4_Locus:
18q22.3

# Metabolic_Enzyme_4_SNPs:
rs4263028; rs11151964; rs9807352; rs12960862; rs2887; rs4891564; rs2346064; rs1004453; rs7239132; rs12604675; rs10469123; rs10469203; rs12607796; rs12605490; rs8087768; rs9319909; rs4892246; rs7506171; rs4329999; rs7242384; rs8085167; rs11876996; rs7244370; rs7506929; rs4892243; rs7231312; rs4892242; rs12605520; rs733686; rs9967490; rs7229005; rs7232853; rs1426256; rs7506957; rs17817095; rs11875756; rs7506825; rs17817180; rs12961730; rs12964027; rs12456406; rs12964208; rs7506760; rs12956997; rs12456388; rs12964454; rs11873844; rs17817345; rs7505047; rs17089382; rs17089414; rs17089390; rs7233066; rs9953129; rs9960024; rs11659237; rs9807248; rs11662276; rs17816861; rs11873901; rs10469124; rs17089403; rs1559809; rs17817077; rs9949100; rs4891563; rs11661606; rs2881289; rs7228575; rs9957229; rs9955944; rs17089375; rs4892244; rs17089411; rs4892239; rs17238585; rs7505555; rs12326826; rs9946796; rs11876764; rs9949990; rs34570315; rs12957330; rs7506936; rs4892241; rs7506258; rs9952652; rs4355018; rs9957885; rs11664748; rs4133234; rs17238285; rs1974965; rs11659364; rs4892238; rs11875122; rs7237549; rs9948919; rs12959707; rs12457983; rs12964810; rs1974963; rs4891562; rs11873542; rs12962343; rs2881288; rs17089378; rs12954161; rs9959794; rs7504932; rs12327522; rs11664535; rs7230673; rs12455650; rs1974964; rs7244647; rs9989559; rs11875810; rs12954438; rs2098910; rs2346061; rs2346063; rs890333; rs2346062; rs2081548; rs890332; rs11538620; rs34522443; rs11538622; rs11538624; rs11538623; rs35604255; rs10533212; rs35771415; rs34713611; rs9967349; rs33922160; rs34365714; rs34526667; rs11875787; rs28448542; rs28871039; rs35084313; rs10549931; rs10685765; rs34874693; rs4891561; rs12606902; rs34117300; rs12959038; rs36228963; rs5826336; rs35735348; rs34499247; rs35885130; rs35388041; rs28713380; rs11151965; rs34138697; rs35204551; rs9966983; rs7505007; rs35096494; rs33950634; rs33981863; rs34142328; rs12959706; rs9955580; rs9947243; rs34869467; rs35788286; rs10624462; rs34283867; rs6566813; rs34962477; rs34335073; rs5826332; rs36060345; rs34573470; rs35682790; rs35362460; rs35860275; rs35365788; rs12964034; rs10522670; rs12959748; rs4892245; rs36111704; rs12969794; rs5826335; rs4891560; rs9965945; rs34070364; rs10624665; rs5826334; rs34842524; rs35877440; rs34785330; rs17089373; rs7233122; rs10596720; rs9948674; rs34189472; rs10562152; rs10649703; rs34321505; rs35707511; rs9949211; rs35368997; rs35691581; rs35734110; rs9953867; rs34563384; rs35469246; rs8087111; rs34726849; rs35932028; rs12969795; rs12969769; rs34799288; rs35234907; rs28800835; rs34646410; rs10685766; rs34895018; rs35597919; rs12961586; rs6566814; rs28877095; rs4892240; rs33911381; rs8088199; rs11872770; rs36206459; rs7350982; rs34145828; rs11447097; rs12104001; rs4892247; rs3080879; rs10663835; rs10871736; rs10871737; rs1130046; rs11664131; rs12327049; rs12456405; rs12954579; rs12966495; rs12967519; rs12970020; rs17089369; rs2114228; rs28534519; rs35248661; rs4353545; rs4891565; rs4891566; rs4892233; rs4892248; rs4892249; rs6566815; rs7238101; rs7504377; rs7506051; rs7506112; rs8096427; rs8099458; rs9319908

# Metabolic_Enzyme_4_General_References:
12975309

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5917

# Metabolic_Enzyme_5_Name:
Histidyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_5_Synonyms:
Histidine--tRNA ligase; HisRS

# Metabolic_Enzyme_5_Gene_Name:
HARS

# Metabolic_Enzyme_5_Protein_Sequence:
>HistidyltRNA synthetase, cytoplasmic
MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPK
GTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQ
GGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAG
NFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDK
LDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLG
DLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAG
GRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKL
LEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRS
VTSREEVDVRREDLVEEIKRRTGQPLCIC

# Metabolic_Enzyme_5_Number_of_Residues:
509

# Metabolic_Enzyme_5_Molecular_Weight:
57411

# Metabolic_Enzyme_5_Theoretical_pI:
5.56

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  histidine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  histidyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  protein biosynthesis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_5_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_5_Specific_Function:
ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)

# Metabolic_Enzyme_5_Pathway:
map00340  Histidine metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_5_Reaction:
ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF03129:HGTP_anticodon;
PF00587:tRNA-synt_2b;
PF00458:WHEP-TRS

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 6.1.1.21

# Metabolic_Enzyme_5_GenBank_ID_Protein:
32460

# Metabolic_Enzyme_5_SwissProt_ID:
SYHC_HUMAN (P12081)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
HARS

# Metabolic_Enzyme_5_Geneatlas_id:
HARS

# Metabolic_Enzyme_5_hgnc_id:
HGNC:4816

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1530 bp
ATGGCAGAGCGTGCGGCGCTGGAGGAGCTGGTGAAACTTCAGGGAGAGCGCGTGCGAGGC
CTCAAGCAGCAGAAGGCCAGCGCCGAGCTGATCGAGGAGGAGGTGGCGAAACTCCTGAAA
CTGAAGGCACAGCTGGGTCCTGATGAAAGCAAACAGAAATTTGTGCTCAAAACCCCCAAG
GGCACAAGAGACTATAGTCCCCGGCAGATGGCAGTTCGCGAGAAGGTGTTTGACGTAATC
ATCCGTTGCTTCAAGCGCCACGGTGCAGAAGTCATTGATACACCTGTATTTGAACTAAAG
GAAACACTGATGGGAAAGTATGGGGAAGACTCCAAGCTTATCTATGACCTGAAGGACCAG
GGCGGGGAGCTCCTGTCCCTTCGCTATGACCTCACTGTTCCTTTTGCTCGGTATTTGGCA
ATGAATAAACTGACCAACATTAAACGCTACCACATAGCAAAGGTATATCGGCGGGATAAC
CCAGCCATGACCCGTGGCCGATACCGGGAATTCTACCAGTGTGATTTTGACATTGCTGGG
AACTTTGATCCCATGATCCCTGATGCAGAGTGCCTGAAGATCATGTGCGAGATCCTGAGT
TCACTTCAGATAGGCGACTTCCTGGTCAAGGTAAACGATCGACGCATTCTAGATGGGATG
TTTGCTATCTGTGGTGTTTCTGACAGCAAGTTCCGTACCATCTGCTCCTCAGTAGACAAG
CTGGACAAGGTGTCCTGGGAAGAGGTGAAGAATGAGATGGTGGGAGAGAAGGGCCTTGCA
CCTGAGGTGGCTGACCGCATTGGGGACTATGTCCAGCAACATGGTGGGGTATCCCTGGTG
GAACAGCTGCTCCAGGATCCTAAACTATCCCAAAACAAGCAGGCCTTGGAGGGCCTGGGA
GACCTGAAGTTGCTCTTTGAGTACCTGACCCTATTTGGCATTGATGACAAAATCTCCTTT
GACCTGAGCCTTGCTCGAGGGCTGGATTACTACACTGGGGTGATCTATGAGGCAGTGCTG
CTACAGACCCCAGCCCAGGCAGGGGAAGAGCCCCTGGGTGTGGGCAGTGTGGCTGCTGGA
GGACGCTATGATGGGCTAGTGGGCATGTTCGACCCCAAAGGGCGCAAGGTGCCATGTGTG
GGGCTCAGCATTGGGGTGGAGCGGATTTTCTCCATCGTGGAACAGAGACTAGAGGCTTTG
GAGGAGAAGATACGGACCACGGAGACACAGGTGCTTGTGGCATCTGCACAGAAGAAGCTG
CTAGAGGAAAGACTAAAGCTTGTCTCAGAACTGTGGGATGCTGGGATCAAGGCTGAGCTG
CTGTACAAGAAGAACCCAAAGCTACTGAACCAGTTACAGTACTGTGAGGAGGCAGGCATC
CCACTGGTGGCTATCATCGGCGAGCAGGAACTCAAGGATGGGGTCATCAAGCTCCGTTCA
GTGACGAGCAGGGAAGAGGTGGATGTCCGAAGAGAAGACCTTGTGGAGGAAATCAAAAGG
AGAACAGGCCAGCCCCTCTGCATCTGCTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
Z11518

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_5_Locus:
5q31.3

# Metabolic_Enzyme_5_SNPs:
rs2230361; rs2073512; rs702396; rs11954514; rs811382; rs801185; rs801189; rs2530239; rs801186; rs1089305; rs812381; rs801187; rs6880190; rs11745372; rs1131045; rs1131041; rs1050250; rs1131042; rs1050246; rs1131040; rs1131035; rs1131034; rs1131039; rs1131046; rs1131036; rs1050247; rs1050249; rs1050251; rs1050248; rs1131032; rs1131043; rs1131038; rs1050245; rs1131033; rs1131044; rs1050252; rs11548124; rs1131037; rs35217222; rs6873628; rs1089304; rs34246519; rs34291233; rs35790592; rs2530240; rs10713463; rs10534451; rs4334930; rs7701545; rs5871749; rs801188; rs11344157; rs12653992; rs10534452; rs13180544; rs10300; rs1050222; rs10515510; rs1065342; rs12513490; rs12652092; rs13169368; rs17119056; rs2251860; rs2286394; rs2302104; rs2530234; rs2530241; rs2530242; rs2530243; rs2530245; rs2530246; rs2563302; rs2563304; rs2563305; rs2563312; rs2563314; rs2563335; rs3177856; rs3180057; rs34342435; rs34589480; rs34732372; rs34790864; rs35080423; rs35983033; rs3887397; rs6880619; rs6883035; rs7706544; rs7715879; rs801168

# Metabolic_Enzyme_5_General_References:
1549469; 3554142; 8406012; 7755634

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5510

# Metabolic_Enzyme_6_Name:
Aromatic-L-amino-acid decarboxylase

# Metabolic_Enzyme_6_Synonyms:
AADC; DOPA decarboxylase; DDC

# Metabolic_Enzyme_6_Gene_Name:
DDC

# Metabolic_Enzyme_6_Protein_Sequence:
>AromaticLaminoacid decarboxylase
MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV
EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD
WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM
EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV
ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN
PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL
KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN
EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE


# Metabolic_Enzyme_6_Number_of_Residues:
480

# Metabolic_Enzyme_6_Molecular_Weight:
53895

# Metabolic_Enzyme_6_Theoretical_pI:
7.21

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
 ||
>>>
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine

# Metabolic_Enzyme_6_Pathway:
map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00901  Indole and ipecac alkaloid biosynthesis;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_6_Reaction:
L-tryptophan = tryptamine + CO2

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00282:Pyridoxal_deC

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 4.1.1.28

# Metabolic_Enzyme_6_GenBank_ID_Protein:
181521

# Metabolic_Enzyme_6_SwissProt_ID:
DDC_HUMAN (P20711)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
DDC

# Metabolic_Enzyme_6_Geneatlas_id:
DDC

# Metabolic_Enzyme_6_hgnc_id:
HGNC:2719

# Metabolic_Enzyme_6_PDB_ID:
1JS3

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>1443 bp
ATGAACGCAAGTGAATTCCGAAGGAGAGGGAAGGAGATGGTGGATTACGTGGCCAACTAC
ATGGAAGGCATTGAGGGACGCCAGGTCTACCCTGACGTGGAGCCCGGGTACCTGCGGCCG
CTGATCCCTGCCGCTGCCCCTCAGGAGCCAGACACGTTTGAGGACATCATCAACGACGTT
GAGAAGATAATCATGCCTGGGGTGACGCACTGGCACAGCCCCTACTTCTTCGCCTACTTC
CCCACTGCCAGCTCGTACCCGGCCATGCTTGCGGACATGCTGTGCGGGGCCATTGGCTGC
ATCGGCTTCTCCTGGGCGGCAAGCCCAGCATGCACAGAGCTGGAGACTGTGATGATGGAC
TGGCTCGGGAAGATGCTGGAACTACCAAAGGCATTTTTGAATGAGAAAGCTGGAGAAGGG
GGAGGAGTGATCCAGGGAAGTGCCAGTGAAGCCACCCTGGTGGCCCTGCTGGCCGCTCGG
ACCAAAGTGATCCATCGGCTGCAGGCAGCGTCCCCAGAGCTCACACAGGCCGCTATCATG
GAGAAGCTGGTGGCTTACTCATCCGATCAGGCACACTCCTCAGTGGAAAGAGCTGGGTTA
ATTGGTGGAGTGAAATTAAAAGCCATCCCCTCAGATGGCAACTTCGCCATGCGTGCGTCT
GCCCTGCAGGAAGCCCTGGAGAGAGACAAAGCGGCTGGCCTGATTCCTTTCTTTATGGTT
GCCACCCTGGGGACCACAACATGCTGCTCCTTTGACAATCTCTTAGAAGTCGGTCCTATC
TGCAACAAGGAAGACATATGGCTGCACGTTGATGCAGCCTACGCAGGCAGTGCATTCATC
TGCCCTGAGTTCCGGCACCTTCTGAATGGAGTGGAGTTTGCAGATTCATTCAACTTTAAT
CCCCACAAATGGCTATTGGTGAATTTTGACTGTTCTGCCATGTGGGTGAAAAAGAGAACA
GACTTAACGGGAGCCTTTAGACTGGACCCCACTTACCTGAAGCACAGCCATCAGGATTCA
GGGCTTATCACTGACTACCGGCATTGGCAGATACCACTGGGCAGAAGATTTCGCTCTTTG
AAAATGTGGTTTGTATTTAGGATGTATGGAGTCAAAGGACTGCAGGCTTATATCCGCAAG
CATGTCCAGCTGTCCCATGAGTTTGAGTCACTGGTGCGCCAGGATCCCCGCTTTGAAATC
TGTGTGGAAGTCATTCTGGGGCTTGTCTGCTTTCGGCTAAAGGGTTCCAACAAAGTGAAT
GAAGCTCTTCTGCAAAGAATAAACAGTGCCAAAAAAATCCACTTGGTTCCATGTCACCTC
AGGGACAAGTTTGTCCTGCGCTTTGCCATCTGTTCTCGCACGGTGGAATCTGCCCATGTG
CAGCGGGCCTGGGAACACATCAAAGAGCTGGCGGCCGACGTGCTGCGAGCAGAGAGGGAG
TAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M76180

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_6_Locus:
7p11

# Metabolic_Enzyme_6_SNPs:
rs6263; rs6262; rs11575542; rs11575292; rs6264; rs11575302; rs11575290; rs921451; rs2329342; rs2329371; rs10499694; rs1451374; rs10276473; rs6949897; rs4452748; rs921450; rs7803440; rs7803788; rs1470747; rs1451375; rs6969081; rs1966839; rs7803903; rs10249420; rs1451373; rs10265930; rs10499695; rs7786398; rs11575548; rs11974297; rs10250513; rs11575551; rs1349491; rs11575549; rs2060762; rs11575288; rs2329341; rs2329343; rs11575286; rs11575550; rs6593002; rs3779074; rs2242041; rs3837091; rs2329340; rs11765748; rs3779075; rs2044859; rs10499696; rs7779110; rs2876830; rs2242042; rs3779076; rs4947644; rs11765109; rs930707; rs11575282; rs11575273; rs17133881; rs4585697; rs11575544; rs17133878; rs10255505; rs11575281; rs6956737; rs11575543; rs11575545; rs2060761; rs11575553; rs6962356; rs11575546; rs10229387; rs11575552; rs11575284; rs11575280; rs6972476; rs11575547; rs6975312; rs998850; rs730092; rs896309; rs880028; rs1376524; rs745043; rs6592962; rs10899734; rs7790758; rs3887825; rs3735274; rs6965432; rs4948196; rs11761683; rs11238134; rs10899735; rs1451371; rs3807556; rs4947580; rs6951323; rs6950777; rs4580999; rs9942686; rs10277662; rs4947584; rs2198144; rs6592961; rs3779078; rs11983581; rs1037351; rs4436083; rs1901312; rs3807552; rs11983757; rs1451372; rs2167364; rs11772714; rs4947577; rs11575457; rs11768267; rs11575334; rs3735273; rs7809758; rs11575320; rs11980368; rs4377912; rs6957607; rs4947582; rs7776816; rs11981575; rs11575464; rs4948201; rs6967361; rs1451370; rs11575536; rs6944090; rs17133853; rs2876827; rs11575340; rs10244632; rs11575489; rs6592952; rs6952023; rs10228056; rs896308; rs11974997; rs11575518; rs4602840; rs11575378; rs11575527; rs11575375; rs12718541; rs11575387; rs745042; rs1817074; rs4579483; rs7791875; rs2122822; rs11575399; rs11575511; rs4947535; rs11575351; rs1376523; rs4992502; rs6947293; rs11575435; rs11575407; rs11575338; rs11575516; rs11763837; rs11575400; rs17133842; rs11575520; rs7777600; rs4397355; rs1901311; rs10274275; rs11575451; rs11575538; rs4948197; rs11575388; rs4947634; rs12667533; rs10268819; rs11575441; rs11575506; rs3779084; rs6974583; rs17133877; rs12718527; rs3807566; rs6979229; rs11238138; rs10499693; rs11982708; rs1982406; rs2329367; rs2100280; rs11238133; rs3807555; rs11575461; rs2876829; rs7803247; rs10899736; rs6951648; rs1007702; rs11575500; rs11771818; rs11575444; rs11575541; rs4329234; rs11575442; rs10239830; rs9918702; rs11575501; rs1007749; rs11575494; rs4947576; rs11575523; rs7780360; rs6963534; rs11982772; rs11575309; rs4947581; rs11575462; rs1349492; rs732215; rs11575322; rs2329365; rs10271341; rs4989851; rs3807558; rs11575298; rs4433100; rs11575537; rs731689; rs4490786; rs4245549; rs896307; rs17634958; rs3757472; rs4470989; rs11238131; rs11575535; rs11982776; rs7808025; rs3807562; rs11575404; rs2122817; rs11575522; rs6592963; rs5884156; rs3807553; rs10249982; rs11575510; rs1470750; rs4947631; rs11575463; rs12718572; rs12535024; rs2329366; rs11575383; rs6955487; rs2122821; rs17665398; rs11765543; rs7809477; rs12538938; rs11575327; rs11575521; rs1451369; rs12112308; rs11575360; rs17553495; rs11575454; rs1817073; rs11575447; rs2167367; rs3823674; rs11575450; rs11575507; rs11575319; rs11575301; rs17152014; rs10239937; rs6970468; rs11575295; rs7785224; rs4947621; rs17733244; rs3470; rs4449741; rs11575532; rs11575460; rs2167366; rs17634717; rs3779083; rs11575423; rs11575504; rs880029; rs17553791; rs6952381; rs11575502; rs9918591; rs11575406; rs11771860; rs11575519; rs1451368; rs2122818; rs11575372; rs11575343; rs11575300; rs11575368; rs11575381; rs13222408; rs11575509; rs12718574; rs11575455; rs11575540; rs11768997; rs7797142; rs17635123; rs7792578; rs11575515; rs11575526; rs11575491; rs11767384; rs6953675; rs7807564; rs11575385; rs2329364; rs11575332; rs11575512; rs11575296; rs12665948; rs11575428; rs11575305; rs11575323; rs11575503; rs11575339; rs11575449; rs6964142; rs2122819; rs11575304; rs2876826; rs11575342; rs11767334; rs11575456; rs17152020; rs11575472; rs4948225; rs11575313; rs3807563; rs7792474; rs11575525; rs11978797; rs10267323; rs2329368; rs11575424; rs2100279; rs11575434; rs6963996; rs11575513; rs11575534; rs11763051; rs11575411; rs11575392; rs11575425; rs11575505; rs11575328; rs17665588; rs11575431; rs4947625; rs6592969; rs11575349; rs11575353; rs2060763; rs12718528; rs11575293; rs11575492; rs6944912; rs11575356; rs2329369; rs11575429; rs11575438; rs7802199; rs3887826; rs11575453; rs11575414; rs11575321; rs2876828; rs12535064; rs7812167; rs6592973; rs11575508; rs1807066; rs1304691; rs11575437; rs11575514; rs17634771; rs1466163; rs11575374; rs7809234; rs3779082; rs11575430; rs12671474; rs11575422; rs7810677; rs3071970; rs11575446; rs11575410; rs11575325; rs2167363; rs17665670; rs13311361; rs11575352; rs11575483; rs11575413; rs7778349; rs6975453; rs11575359; rs12718529; rs1451366; rs11575531; rs11575493; rs1597639; rs11575528; rs4948010; rs4947510; rs3829897; rs11575575; rs6593010; rs11575557; rs4947511; rs11575565; rs11575568; rs11575564; rs11575574; rs11575266; rs10278338; rs11575562; rs11575259; rs11575264; rs11575561; rs11575570; rs11575271; rs11575566; rs11575569; rs11575267; rs11575556; rs11575268; rs11575376; rs11575377; rs11575291; rs12670911; rs10233346; rs11575274; rs28607134; rs28799122; rs34618339; rs13223166; rs11302809; rs4515495; rs10281167; rs34752519; rs2242040; rs13223157; rs13233973; rs13245496; rs2242039; rs5884158; rs13237075; rs2329370; rs28510954; rs10600316; rs10229102; rs13226079; rs3071145; rs11366731; rs10601831; rs35197006; rs7791943; rs2242038; rs5014165; rs13226287; rs7782081; rs12718674; rs11575276; rs2167368; rs10255145; rs11575277; rs34606153; rs6975015; rs11410259; rs10229369; rs10247443; rs11575275; rs10609620; rs7787209; rs13245018; rs34348593; rs1988550; rs35330002; rs35591152; rs11450560; rs11575468; rs34658291; rs11575395; rs35299591; rs34021747; rs35586188; rs11575432; rs34314851; rs35089176; rs35997922; rs12537169; rs12718558; rs11575294; rs1470749; rs11315611; rs11575315; rs13228083; rs35582115; rs4947588; rs13308328; rs3779077; rs3807554; rs5884157; rs7811992; rs12718563; rs36110443; rs11575482; rs11330628; rs1107742; rs731690; rs11575433; rs4948216; rs11575311; rs11575326; rs6965025; rs11575347; rs11575474; rs11575316; rs11575459; rs35993062; rs3840579; rs11575314; rs11575465; rs5884154; rs3779080; rs34950596; rs2198143; rs10718396; rs10587155; rs36090705; rs34869137; rs11575533; rs3071964; rs13234331; rs34002033; rs1137337; rs34977933; rs3779081; rs35173748; rs1470748; rs12538830; rs4947594; rs11575497; rs35008528; rs4947589; rs2084723; rs11575306; rs34971815; rs34780941; rs13222708; rs11575346; rs1107743; rs6953661; rs12718583; rs11575329; rs6959596; rs36104801; rs7794360; rs11763809; rs13244875; rs11575362; rs11575415; rs28889020; rs35666388; rs35765995; rs6968322; rs11575389; rs11761208; rs33974864; rs6975747; rs13232900; rs34329145; rs11575369; rs7810684; rs11978769; rs4143196; rs28706313; rs3071975; rs7781950; rs28534613; rs12718611; rs4377913; rs1580031; rs5884155; rs28531762; rs34984600; rs11309882; rs11575318; rs35539624; rs11575333; rs36063027; rs11980236; rs7785984; rs35432113; rs34298125; rs11575363; rs7455902; rs7786752; rs10258321; rs34582666; rs11575397; rs11575530; rs4455783; rs11575529; rs11575312; rs33945116; rs4948205; rs1304693; rs11575401; rs35915381; rs2122820; rs34487683; rs11763807; rs13225182; rs6960966; rs34791889; rs36005269; rs11575303; rs6952938; rs6964313; rs10710723; rs11575417; rs1901313; rs11378977; rs11575524; rs11575394; rs13229021; rs11575308; rs11575348; rs12666643; rs11575499; rs35269833; rs11575393; rs11575330; rs4052336; rs3071963; rs11575458; rs11575367; rs13228086; rs35484306; rs7793185; rs11575390; rs12537186; rs35092758; rs3807557; rs11575555; rs11575554; rs11575269; rs11575567; rs11575257; rs11575559; rs11575265; rs11575261; rs11575571; rs11575270; rs11575572; rs35937247; rs11575260; rs4947662; rs13243080; rs11575563; rs35517528; rs10499697; rs11238214; rs11489734; rs11977135; rs12666409; rs13228274; rs3911193; rs4947396; rs6593011; rs7790230; rs7804365; rs7807335; rs978784

# Metabolic_Enzyme_6_General_References:
2590185; 1612608; 1540578; 8510497; 1395716; 10391209

# Metabolic_Enzyme_6_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8562

# Macromolecular_Interacting_Partner_1_Name:
System N amino acid transporter 1

# Macromolecular_Interacting_Partner_1_Synonyms:
SN1; N-system amino acid transporter 1; Solute carrier family 38 member 3

# Macromolecular_Interacting_Partner_1_Gene_Name:
SLC38A3

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>System N amino acid transporter 1
MEAPLQTEMVELVPNGKHSEGLLPVITPMAGNQRVEDPARSCMEGKSFLQKSPSKEPHFT
DFEGKTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLLTAVALLSSYSIHLLLKS
SGVVGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSYLYIIKSELPLVIQTFLNLEE
KTSDWYMNGNYLVILVSVTIILPLALMRQLGYLGYSSGFSLSCMVFFLIAVIYKKFHVPC
PLPPNFNNTTGNFSHVEIVKEKVQLQVEPEASAFCTPSYFTLNSQTAYTIPIMAFAFVCH
PEVLPIYTELKDPSKKKMQHISNLSIAVMYIMYFLAALFGYLTFYNGVESELLHTYSKVD
PFDVLILCVRVAVLTAVTLTVPIVLFPVRRAIQQMLFPNQEFSWLRHVLIAVGLLTCINL
LVIFAPNILGIFGVIGATSAPFLIFIFPAIFYFRIMPTEKEPARSTPKILALCFAMLGFL
LMTMSLSFIIIDWASGTSRHGGNH

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
504

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
55774

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
8.01

# Macromolecular_Interacting_Partner_1_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_1_Specific_Function:
Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_1_Signals:
1-111

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
83-103
106-126
144-164
187-207
213-233
324-344
366-386
408-428
431-451
471-491

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
S38A3_HUMAN (Q99624)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
SLC38A3

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
SLC38A3

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:18044

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cell membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AF244548

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_1_Locus:
3p21.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs2282749; rs4141407; rs2236939; rs2236940; rs2236941; rs2236942; rs739431; rs886075; rs2282750; rs35742391; rs739430; rs2006199; rs1858828; rs13084560; rs13320226; rs13084362; rs34370846; rs35137368; rs35768187; rs13084716; rs4688744; rs13084528; rs11709574; rs11293008; rs34840478; rs35219849; rs35195846; rs9847853; rs11385619; rs35374338; rs13084685; rs13084700; rs12635271; rs34366896; rs6792754; rs13064707; rs13084344; rs13084819; rs35306902; rs6779184; rs13084686; rs6791799; rs33915788; rs3831498; rs35926495; rs34382606; rs5848902; rs11442070; rs35686060; rs34974687; rs35851247; rs5848903; rs7611366; rs35756060; rs35667988; rs11919418; rs12485909; rs12631192; rs13064381; rs34877766; rs4525859; rs4688682; rs4688683; rs4688745; rs7617915; rs9883222

# Macromolecular_Interacting_Partner_1_General_References:
10823827; 11085536

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8594

# Macromolecular_Interacting_Partner_2_Name:
SLC38A2 protein

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
SLC38A2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>SLC38A2 protein
MKQNLILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIG
AMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGY
TSGLSLLCMVFFLIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDS
CRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYL
LAALFGYLTFYEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTH
LLCASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIK
LVKKEPMKSVQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
406

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
45180

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
8.88

# Macromolecular_Interacting_Partner_2_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_2_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_2_Signals:
1-18

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
5-23; 48-69; 89-111; 115-137; 230-252; 272-294; 315-334; 339-361; 373-395

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
Q6IA88_HUMAN (Q6IA88)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
SLC38A2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
SLC38A2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:13448

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
CR457267

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_2_Locus:
12q

# Macromolecular_Interacting_Partner_2_SNPs:
rs10880961; rs7968283; rs956910; rs2897968; rs7968173; rs7961994; rs10880959; rs2307063; rs1873793; rs3742061; rs2307061; rs10880960; rs3782904; rs7965930; rs2307062; rs2279559; rs7974529; rs7960147; rs10785624; rs11183450; rs34139863; rs36065261; rs36022751; rs11340856; rs7966787; rs11313787; rs5797976; rs1046296; rs11183449; rs12307969; rs2307060; rs36019260; rs3837525; rs35534621; rs11183447; rs3832874; rs3830356; rs34489723; rs36066221; rs11298796; rs7295472; rs35732850; rs35944767; rs34099989; rs10880962; rs11183446; rs12368989; rs1492896; rs17096884; rs4768697; rs4768698; rs7135630; rs7967840; rs7975820; rs7979418

# Macromolecular_Interacting_Partner_2_General_References:
Not Available

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8673

# Macromolecular_Interacting_Partner_3_Name:
Sodium-coupled neutral amino acid transporter 4

# Macromolecular_Interacting_Partner_3_Synonyms:
Na(+-coupled neutral amino acid transporter 4; Amino acid transporter A3; System A amino acid transporter 3; System N amino acid transporter 3; Solute carrier family 38 member 4

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC38A4

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Sodiumcoupled neutral amino acid transporter 4
MDPMELRNVNIEPDDESSSGESAPDSYIGIGNSEKAAMSSQFANEDTESQKFLTNGFLGK
KKLADYADEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSL
YSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEV
IRAFMGLEENTGEWYLNGNYLIIFVSVGIILPLSLLKNLGYLGYTSGFSLTCMVFFVSVV
IYKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLPNNSESSDVNFMMDYTHRNPAGLDEN
QAKGSLHDSGVEYEAHSDDKCEPKYFVFNSRTAYAIPILVFAFVCHPEVLPIYSELKDRS
RRKMQTVSNISITGMLVMYLLAALFGYLTFYGEVEDELLHAYSKVYTLDIPLLMVRLAVL
VAVTLTVPIVLFPIRTSVITLLFPKRPFSWIRHFLIAAVLIALNNVLVILVPTIKYIFGF
IGASSATMLIFILPAVFYLKLVKKETFRSPQKVGALIFLVVGIFFMIGSMALIIIDWIYD
PPNSKHH

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
547

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
60765

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.45

# Macromolecular_Interacting_Partner_3_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_3_Specific_Function:
Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_3_Signals:
1-531

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
81-101
105-125
152-172
196-216
221-241
333-353
370-390
412-432
454-474
477-497
515-535

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
13876616

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
S38A4_HUMAN (Q969I6)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC38A4

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC38A4

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:14679

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cell membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1644 bp
ATGGATCCCATGGAACTGAGAAATGTCAACATCGAACCAGATGATGAGAGCAGCAGTGGA
GAAAGTGCTCCAGATAGCTACATCGGGATAGGAAATTCAGAAAAGGCAGCAATGAGCAGT
CAATTTGCTAATGAAGACACTGAAAGTCAGAAATTCCTGACAAATGGATTTTTGGGGAAA
AAGAAGCTGGCAGATTATGCTGATGAACACCATCCCGGAACCACTTCCTTTGGAATGTCT
TCATTTAACCTGAGTAATGCCATCATGGGCAGTGGGATCCTGGGCTTGTCCTATGCCATG
GCCAACACAGGGATCATACTTTTTATAATCATGCTGCTTGCTGTGGCAATATTATCACTG
TATTCAGTTCACCTTTTATTAAAAACAGCCAAGGAAGGAGGGTCTTTGATTTATGAAAAA
TTAGGAGAAAAGGCATTTGGATGGCCGGGAAAAATTGGAGCTTTTGTTTCCATTACAATG
CAGAACATTGGAGCAATGTCAAGCTACCTCTTTATCATTAAATATGAACTACCTGAAGTA
ATCAGAGCATTCATGGGACTTGAAGAAAATACTGGAGAATGGTACCTCAATGGCAACTAC
CTCATCATATTTGTGTCTGTTGGAATTATTCTTCCACTTTCGCTCCTTAAAAATTTAGGT
TATCTTGGCTATACCAGTGGATTTTCTCTTACCTGCATGGTGTTTTTTGTTAGTGTGGTG
ATTTACAAGAAATTCCAAATACCCTGCCCTCTACCTGTTTTGGATCACAGTGTTGGAAAT
CTGTCATTCAACAACACGCTTCCAATGCATGTGGTAATGTTACCCAACAACTCTGAGAGT
TCTGATGTGAACTTCATGATGGATTACACCCACCGCAATCCTGCAGGGCTGGATGAGAAC
CAGGCCAAGGGCTCTCTTCATGACAGTGGAGTAGAATATGAAGCTCATAGTGATGACAAG
TGTGAACCCAAATACTTTGTATTCAACTCCCGGACGGCCTATGCAATTCCTATCCTAGTA
TTTGCTTTTGTATGCCACCCTGAGGTCCTTCCCATCTACAGTGAACTTAAAGATCGGTCC
CGGAGAAAAATGCAAACGGTGTCAAATATTTCCATCACGGGGATGCTTGTCATGTACCTG
CTTGCCGCCCTCTTTGGTTACCTAACCTTCTATGGAGAAGTTGAAGATGAATTACTTCAT
GCCTACAGCAAAGTGTATACATTAGACATCCCTCTTCTCATGGTTCGCCTGGCAGTCCTT
GTGGCAGTAACACTAACTGTGCCCATTGTCCTCTTCCCAATTCGTACATCAGTGATCACA
CTGTTATTTCCCAAACGACCCTTCAGCTGGATACGACATTTCCTGATTGCAGCTGTGCTT
ATTGCACTTAATAATGTTCTGGTCATCCTTGTGCCAACTATAAAATACATCTTCGGATTC
ATAGGGGCTTCTTCTGCCACTATGCTGATTTTTATTCTTCCAGCAGTTTTTTATCTTAAA
CTTGTCAAGAAAGAAACTTTTAGGTCACCCCAAAAGGTCGGGGCTTTAATTTTCCTTGTG
GTTGGAATATTCTTCATGATTGGAAGCATGGCACTCATTATAATTGACTGGATTTATGAT
CCTCCAAATTCCAAGCATCACTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF305814

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_3_Locus:
12q13

# Macromolecular_Interacting_Partner_3_SNPs:
rs2429467; rs11183610; rs180414; rs2465604; rs2429472; rs2250010; rs2191162; rs2715788; rs2465608; rs2430921; rs4627160; rs11183605; rs180438; rs2897981; rs10881001; rs2079787; rs7974413; rs11183618; rs2429470; rs4482114; rs11183617; rs7963399; rs11183616; rs7967842; rs4587804; rs7132006; rs10161209; rs2109125; rs11183619; rs2465605; rs3862137; rs4569081; rs11183620; rs12321267; rs12582305; rs12424453; rs7968752; rs7954772; rs2429473; rs7963807; rs2465586; rs17097332; rs4447249; rs7138295; rs7959916; rs7953215; rs7973308; rs12304394; rs4491335; rs180437; rs12301396; rs10748455; rs2429471; rs12300935; rs4554975; rs12318696; rs10437941; rs7963364; rs10881002; rs7971412; rs7974393; rs12227634; rs17666239; rs12301345; rs11183621; rs17097341; rs10881003; rs180430; rs180431; rs2715779; rs2465585; rs180416; rs2465584; rs180421; rs1860372; rs180408; rs180433; rs180410; rs180409; rs180420; rs180417; rs7297226; rs4768758; rs2287471; rs180427; rs180419; rs2429474; rs4768759; rs2430922; rs2465583; rs6582676; rs180407; rs11183608; rs2465582; rs180434; rs180405; rs11183609; rs180426; rs180435; rs180412; rs2465644; rs12307687; rs180424; rs180429; rs180415; rs17097246; rs2075335; rs12305532; rs180428; rs12316767; rs2287472; rs12581848; rs12307218; rs4768757; rs180425; rs12317419; rs12306007; rs3794308; rs12301214; rs2302855; rs180423; rs180403; rs17097220; rs12313427; rs17602430; rs1860371; rs12826359; rs180422; rs2429465; rs2287473; rs17097286; rs11609184; rs2429466; rs180436; rs180404; rs1468970; rs1468972; rs1468971; rs2465614; rs4340151; rs2430920; rs2465613; rs12315893; rs7489259; rs7976413; rs7962993; rs7965688; rs7976286; rs4262792; rs12309262; rs35448881; rs5797999; rs12426237; rs34557682; rs10523982; rs12824626; rs2543339; rs4537845; rs34666594; rs2429469; rs10161451; rs34886536; rs5798000; rs4575359; rs11558891; rs9804926; rs10693721; rs4388977; rs2430923; rs2429468; rs34878223; rs3764027; rs2465606; rs2465588; rs35064296; rs17097355; rs34251832; rs12308177; rs1072246; rs2465587; rs4335624; rs5798001; rs2907513; rs12819255; rs4768756; rs2532606; rs11370884; rs34540549; rs12298652; rs34594658; rs4623983; rs35779004; rs35709312; rs2429464; rs10691485; rs12832145; rs35826321; rs180413; rs2216433; rs35066357; rs12319423; rs2465616; rs10691484; rs11610757; rs11315253; rs34637197; rs17097192; rs35050099; rs7313706; rs549755; rs36053062; rs11335369; rs3217194; rs11183614; rs12318924; rs4631970; rs34909119; rs12316757; rs180411; rs180432; rs10673975; rs34246069; rs35085914; rs180406; rs34654635; rs34189139; rs11335992; rs4439596; rs416435; rs35774013; rs5797998; rs3958775; rs35668113; rs446993; rs180418; rs34764764; rs34209899; rs11338774; rs10785645; rs11183625; rs11609070; rs11615573; rs12307895; rs12311057; rs12317975; rs12318756; rs12318994; rs12812119; rs17097368; rs17684703; rs2193649; rs2216432; rs2408623; rs2430917; rs2430919; rs2465595; rs2715775; rs2715783; rs4374015; rs4495962; rs4497488; rs4511364; rs4533116; rs4994910; rs7953233; rs7955552; rs7964210; rs7978689; rs7978822; rs7978926

# Macromolecular_Interacting_Partner_3_General_References:
11342143; 11414754

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8881

# Macromolecular_Interacting_Partner_4_Name:
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

# Macromolecular_Interacting_Partner_4_Synonyms:
Amino acid transporter ATB0+; Solute carrier family 6 member 14

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC6A14

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Sodium and chloridedependent neutral and basic amino acid transporter B0+
MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVW
RFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGIT
MVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNK
GIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLA
LCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQ
SNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVF
AGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLG
LDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHF
CAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAI
FIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCC
RPASNWGPYLEQHRGERYKDMVDPKKEADHEIPTVSGSRKPE

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
642

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
72154

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.27

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
 Function:  transporter activity
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_4_Signals:
1-469

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
45-65
72-92
110-130
235-255
261-281
315-335
348-368
399-419
450-477
480-500
528-548
563-583

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
5732680

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
S6A14_HUMAN (Q9UN76)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC6A14

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC6A14

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11047

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1929 bp
ATGGACAAGTTGAAATGCCCGAGTTTCTTCAAGTGCAGGGAGAAGGAGAAAGTGTCGGCT
TCATCAGAGAATTTCCATGTTGGTGAAAATGATGAGAATCAGGACCGTGGTAACTGGTCC
AAAAAATCGGATTATCTTCTATCTATGATTGGATACGCAGTGGGATTAGGAAATGTGTGG
AGATTTCCATATCTGACCTACAGCAATGGTGGAGGCGCCTTCTTGATACCTTATGCAATT
ATGTTAGCATTGGCTGGTTTACCTTTGTTCTTTCTGGAGTGTTCACTGGGACAATTTGCT
AGCTTAGGTCCAGTTTCAGTTTGGAGGATTCTTCCATTGTTTCAAGGTGTGGGAATTACA
ATGGTCCTGATCTCCATTTTTGTGACAATCTATTACAATGTCATAATTGCCTATAGTCTT
TACTACATGTTTGCTTCTTTTCAAAGTGAACTACCATGGAAAAATTGTTCTTCGTGGTCA
GATAAAAACTGTAGCAGATCACCAATAGTAACTCACTGTAATGTGAGTACAGTGAATAAA
GGAATACAAGAGATCATCCAAATGAATAAAAGCTGGGTAGACATCAACAATTTTACCTGC
ATCAACGGCAGTGAAATTTATCAGCCAGGGCAGCTTCCCAGTGAACAATATTGGAATAAA
GTGGCGCTCCAACGGTCAAGTGGAATGAATGAGACTGGAGTAATTGTTTGGTATTTAGCA
CTTTGTCTTCTTCTGGCTTGGCTCATAGTTGGAGCAGCACTATTTAAAGGAATCAAATCG
TCTGGCAAGGTGGTATATTTTACAGCTCTTTTCCCCTATGTGGTCCTACTCATCCTGTTA
GTACGAGGTGCAACTCTGGAGGGTGCTTCAAAAGGCATTTCATACTATATTGGAGCCCAG
TCAAATTTTACAAAACTTAAGGAAGCTGAGGTATGGAAAGATGCTGCCACTCAGATATTT
TACTCCCTTTCAGTGGCTTGGGGTGGCTTAGTTGCTCTATCATCTTACAATAAGTTCAAA
AACAACTGCTTCTCTGATGCCATTGTGGTTTGTTTGACAAACTGTCTCACTAGCGTGTTT
GCTGGATTTGCTATTTTTTCTATATTGGGACACATGGCCCATATATCTGGAAAGGAAGTT
TCTCAAGTTGTAAAATCAGGTTTTGATTTGGCATTCATTGCCTATCCAGAGGCTCTAGCC
CAACTCCCAGGTGGTCCATTTTGGTCCATATTATTTTTTTTCATGCTTTTAACTTTGGGT
CTCGATTCTCAGTTTGCTTCGATTGAAACGATCACAACAACAATTCAAGATTTATTTCCC
AAAGTGATGAAGAAAATGAGGGTTCCCATAACTTTGGGCTGCTGCTTGGTTTTGTTTCTC
CTTGGTCTCGTCTGTGTGACTCAGGCTGGAATTTACTGGGTTCATCTGATTGACCACTTC
TGTGCTGGATGGGGCATTTTAATTGCAGCTATACTGGAGCTAGTTGGAATCATCTGGATT
TATGGAGGGAACAGATTCATTGAGGATACAGAAATGATGATTGGAGCAAAGAGGTGGATA
TTCTGGCTATGGTGGAGAGCTTGCTGGTTTGTAATTACGCCTATCCTTTTGATTGCAATA
TTTATCTGGTCATTGGTGCAATTTCATAGACCTAATTATGGCGCAATTCCATACCCTGAC
TGGGGAGTTGCTTTAGGCTGGTGTATGATTGTTTTCTGCATTATTTGGATACCAATTATG
GCTATCATAAAAATAATTCAGGCTAAAGGAAACATCTTTCAACGCCTTATAAGTTGCTGC
AGACCAGCTTCTAACTGGGGTCCATACCTGGAACAACATCGTGGGGAAAGATATAAAGAC
ATGGTAGATCCTAAAAAAGAGGCTGACCATGAAATACCTACTGTTAGTGGCAGCAGAAAA
CCGGAATGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
AF151978

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_4_Locus:
Xq23-q24

# Macromolecular_Interacting_Partner_4_SNPs:
rs12720074; rs2011162; rs5905179; rs12710570; rs5905289; rs2011198; rs2312055; rs2032525; rs5905176; rs5905284; rs7059155; rs2071877; rs4824325; rs10217924; rs5905178; rs6608646; rs12392462; rs2312057; rs12391221; rs17242824; rs5905288; rs12559530; rs10218102; rs10521579; rs12710569; rs10521578; rs5905285; rs5952101; rs12720080; rs12720088; rs5952099; rs12720083; rs5905177; rs4824358; rs4824324; rs12720076; rs4824359; rs12720084; rs12720079; rs5952103; rs2312056; rs12720089; rs17095419; rs12393509; rs4824323; rs2312054; rs7052454; rs12710568; rs12720073; rs12834312; rs3788766; rs5905283; rs12720085; rs28523889; rs6608648; rs11350870; rs34685017; rs28699570; rs12720092; rs28628632; rs12720078; rs5952174; rs35604008; rs5952104; rs5905287; rs6608645; rs12388847; rs10629819; rs12720087; rs12720091; rs35269408; rs17308739; rs3043424; rs35542990; rs5952100; rs5952102; rs35201069; rs6651554; rs12720077; rs10218234; rs6608647; rs12858125; rs34117081; rs5952175; rs12720082; rs34490652; rs4068397; rs7066547; rs7054956; rs12832551; rs10218418; rs12720075; rs12720086; rs12720090; rs35315031; rs7062559; rs10218017; rs12390279; rs12833869; rs12835480; rs12839137; rs12844003; rs17308697; rs2103697; rs2301451; rs5952181; rs6520234; rs6608511; rs6608514; rs6608644; rs6608650

# Macromolecular_Interacting_Partner_4_General_References:
10446133

# Macromolecular_Interacting_Partner_4_References:
Not Available

End of HMDB00177

Beginning of HMDB00181
# Accession_No:
HMDB00181

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-19 15:33:54

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
L-Dopa

# Description:
The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.

# Synonyms:
(-)-3,4-Dihydroxyphenylalanine; (-)-Dopa; 3,4-Dihydroxy-L-phenylalanine; 3,4-Dihydroxyphenyl-L-alanine; 3,4-Dihydroxyphenylalanine; 3-(3,4-Dihydroxyphenyl)-L-alanine; 3-Hydroxy-L-tyrosine; Bendopa; Cidandopa; DOPA; Deadopa; Dihydroxy-L-phenylalanine; Dihydroxyphenylalanine; Dopaflex; Dopaidan; Dopal; Dopalina; Dopar; Doparkine; Doparl; Dopasol; Dopaston; Dopaston SE; Dopastone; Dopastral; Dopicar; Doprin; Eldopal; Eldopar; Eldopatec; Eurodopa; Helfo-dopa; Insulamina; L-(-)-Dopa; L-3-(3,4-Dihydroxyphenyl)alanine; L-3-(3,4-dihydroxyphenyl)-Alanine; L-3,4-dihydroxyphenylalanine; L-4,5-Dihydroxyphenylalanine; L-DOPA; L-Dihydroxyphenylalanine; L-b-(3,4-Dihydroxyphenyl)-a-alanine; Laradopa; Larodopa; Ledopa; Levedopa; Levodopa; Levopa; Maipedopa; Parda; Pardopa; Prodopa; Syndopa; Veldopa; Weldopa; b-(3,4-Dihydroxyphenyl)-L-alanine; b-(3,4-Dihydroxyphenyl)-a-L-alanine; b-(3,4-Dihydroxyphenyl)alanine; L-beta-(3,4-Dihydroxyphenyl)-alpha-alanine; beta-(3,4-Dihydroxyphenyl)-L-alanine; beta-(3,4-Dihydroxyphenyl)-alpha-L-alanine; beta-(3,4-Dihydroxyphenyl)alanine

# Chemical_IUPAC_Name:
2-amino-3-(3,4-dihydroxy-phenyl)-propionic acid

# Chemical_Formula:
C9H11NO4

# Chemical_Structure:
tbl_chemical:::HMDB00181_ZOOM.png:::119283237224469577

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00181_THUMB.png:::119283237063473646

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Catecholamines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
phenol or hydroxyhetarene; 1,2-diphenol; primary amine; primary aliphatic amine (alkylamine); carboxylic acid; aromatic compound; alpha-aminoacid

# Taxonomy_Biofunction:
Component of Riboflavin metabolism; Component of Stilbene, coumarine and lignin biosynthesis; Component of Tyrosine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
197.06880

# Molecular_Weight_Avg:
197.18794

# Smiles_String_isomeric:
N[C@@H](CC1=CC(O)=C(O)C=C1)C(O)=O

# Smiles_String_canonical:
NC(CC1=CC(O)=C(O)C=C1)C(O)=O

# KEGG_Compound_ID:
C00355

# BioCyc_ID:
L-DOPA

# PubChem_CID:
6047

# PubChem_SID:
3136680; 11368472; 11466045; 11537951; 11360866; 222573; 7847127; 8143351; 11335627; 8001566; 11467165; 836454; 11532916; 11365910; 11484127; 11492354; 10321285; 11363348; 7854281; 8153771; 11112155; 8150164; 11485710; 11374316; 11111115; 11488312; 7979689; 11494268; 11461838; 7886892; 11376634; 3648; 148922; 742141

# OMIM_ID:
128230; 134700; 168100; 182125; 253320; 261640; 605407

# Metagene_ID:
AROMATIC L-AMINO ACID DECARBOXYLASE DEFICIENCY: 354

# BiGG_ID:
34719

# Wikipedia_ID:
L-Dopa

# METLIN_ID:
42

# Ref_ID:
15935475; 3127089; 8472357; 15936832; 7760062; 6416708; 12898345; 11327596; 1755339; 2113342; 6995221; 7371653; 1281049; 16176068; 12649306; 15591656; 12898346; 12703659

# ChEBI_ID:
15765

# CAS_Registry_Number:
59-92-7

# InChI:
InChI=1/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1

# Synthesis_Reference:
Applied Microbiology  (1971),  22(4),  721-2.

# Melting_Point:
285 oC

# Melting_Point_predicted:
111.7 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
5.0 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
3.3 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-2.39 [SANGSTER (1993)]

# LogP_predicted:
-2.31 [Predicted by ALOGPS]; -2.244 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::L-Dopa.pdf:::1132562212166371390

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00181.mol:::118124547973952708

# SDF_File_[Text]:
tbl_chemical:::HMDB00181.sdf:::119283236720516386

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00181.pdb:::119283236925841177

# PDB_ID:
1IVV

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::labm00181.mlims.zip:::118114757074234600

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050104_P00_09_1S_Assigned.png:::118114757077098616

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050104_P00_09_IS_2DHSQC_70.jpg:::114781182995574594

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050104_P00_09_IS_2DHSQC_70.zip:::114781182996624322

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050104_P00_09_IS_2DHSQC_70_Assigned.jpg:::116284331456424136

# Predicted_H_NMR_Spectrum:
tbl_chemical:::L-Dopa.gif:::1132732119046471119

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00181_peaks.txt:::1156309600096640322

# Predicted_C_NMR_Spectrum:
tbl_chemical:::L-Dopa_C.gif:::1132737713307380489

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00181_peaks.txt:::1156310789451786499

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00181L.png:::11755526349158066; Medium Energy:tbl_ms:::HMDB00181M.png:::117555268812190568; High Energy:tbl_ms:::HMDB00181H.png:::117555272002224736

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; Extracellular

# Tissue_Location:
Adrenal Medulla; Bladder; Brain; Epidermis; Intestine; Muscle; Nerves; Neurons; Placenta; Platelet; Striatum

# deuterated:
No

# Biofluid_Location:
Blood; CSF

# Concentration_[Normal]:
Blood	0.00723 +/- 0.00097	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	0.0035 +/- 0.0009	umol/L	Adult:>18_yrs_old	N/A	Normal	3127089


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Dyskinesia; Dystonia; Parkinsonism

# Pathway_Names:
Tyrosine metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00350

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5319

# Metabolic_Enzyme_1_Name:
Tyrosinase precursor

# Metabolic_Enzyme_1_Synonyms:
Monophenol monooxygenase; Tumor rejection antigen AB; SK29-AB; LB24-AB

# Metabolic_Enzyme_1_Gene_Name:
TYR

# Metabolic_Enzyme_1_Protein_Sequence:
>Tyrosinase precursor
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILL
SNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVR
RNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMH
YYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRD
AEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRN
PGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQS
SMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGH
NRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLG
AAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL

# Metabolic_Enzyme_1_Number_of_Residues:
529

# Metabolic_Enzyme_1_Molecular_Weight:
60394

# Metabolic_Enzyme_1_Theoretical_pI:
6.05

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone

# Metabolic_Enzyme_1_Pathway:
map00350  Tyrosine metabolism;
 map00740  Riboflavin metabolism;
 map00940  Stilbene, coumarine and lignin biosynthesis;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_1_Reaction:
L-tyrosine + L-dopa + O2 = L-dopa + dopaquinone + H2O

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00264:Tyrosinase

# Metabolic_Enzyme_1_Signals:
1-18

# Metabolic_Enzyme_1_Transmembrane_Regions:
477-497

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.14.18.1

# Metabolic_Enzyme_1_GenBank_ID_Protein:
340037

# Metabolic_Enzyme_1_SwissProt_ID:
TYRO_HUMAN (P14679)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
TYR

# Metabolic_Enzyme_1_Geneatlas_id:
TYR

# Metabolic_Enzyme_1_hgnc_id:
HGNC:12442

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Melanosome; melanosomal membrane; single- pass type I membrane protein

# Metabolic_Enzyme_1_Gene_Sequence:
>1590 bp
ATGCTCCTGGCTGTTTTGTACTGCCTGCTGTGGAGTTTCCAGACCTCCGCTGGCCATTTC
CCTAGAGCCTGTGTCTCCTCTAAGAACCTGATGGAGAAGGAATGCTGTCCACCGTGGAGC
GGGGACAGGAGTCCCTGTGGCCAGCTTTCAGGCAGAGGTTCCTGTCAGAATATCCTTCTG
TCCAATGCACCACTTGGGCCTCAATTTCCCTTCACAGGGGTGGATGACCGGGAGTCGTGG
CCTTCCGTCTTTTATAATAGGACCTGCCAGTGCTCTGGCAACTTCATGGGATTCAACTGT
GGAAACTGCAAGTTTGGCTTTTGGGGACCAAACTGCACAGAGAGACGACTCTTGGTGAGA
AGAAACATCTTCGATTTGAGTGCCCCAGAGAAGGACAAATTTTTTGCCTACCTCACTTTA
GCAAAGCATACCATCAGCTCAGACTATGTCATCCCCATAGGGACCTATGGCCAAATGAAA
AATGGATCAACACCCATGTTTAACGACATCAATATTTATGACCTCTTTGTCTGGATGCAT
TATTATGTGTCAATGGATGCACTGCTTGGGGGATCTGAAATCTGGAGAGACATTGATTTT
GCCCATGAAGCACCAGCTTTTCTGCCTTGGCATAGACTCTTCTTGTTGCGGTGGGAACAA
GAAATCCAGAAGCTGACAGGAGATGAAAACTTCACTATTCCATATTGGGACTGGCGGGAT
GCAGAAAAGTGTGACATTTGCACAGATGAGTACATGGGAGGTCAGCACCCCACAAATCCT
AACTTACTCAGCCCAGCATCATTCTTCTCCTCTTGGCAGATTGTCTGTAGCCGATTGGAG
GAGTACAACAGCCATCAGTCTTTATGCAATGGAACGCCCGAGGGACCTTTACGGCGTAAT
CCTGGAAACCATGACAAATCCAGAACCCCAAGGCTCCCCTCTTCAGCTGATGTAGAATTT
TGCCTGAGTTTGACCCAATATGAATCTGGTTCCATGGATAAAGCTGCCAATTTCAGCTTT
AGAAATACACTGGAAGGATTTGCTAGTCCACTTACTGGGATAGCGGATGCCTCTCAAAGC
AGCATGCACAATGCCTTGCACATCTATATGAATGGAACAATGTCCCAGGTACAGGGATCT
GCCAACGATCCTATCTTCCTTCTTCACCATGCATTTGTTGACAGTATTTTTGAGCAGTGG
CTCCGAAGGCACCGTCCTCTTCAAGAAGTTTATCCAGAAGCCAATGCACCCATTGGACAT
AACCGGGAATCCTACATGGTTCCTTTTATACCACTGTACAGAAATGGTGATTTCTTTATT
TCATCCAAAGATCTGGGCTATGACTATAGCTATCTACAAGATTCAGACCCAGACTCTTTT
CAAGACTACATTAAGTCCTATTTGGAACAAGCGAGTCGGATCTGGTCATGGCTCCTTGGG
GCGGCGATGGTAGGGGCCGTCCTCACTGCCCTGCTGGCAGGGCTTGTGAGCTTGCTGTGT
CGTCACAAGAGAAAGCAGCTTCCTGAAGAAAAGCAGCCACTCCTCATGGAGAAAGAGGAT
TACCACAGCTTGTATCAGAGCCATTTATAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M27160

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_1_Locus:
11q14-q21

# Metabolic_Enzyme_1_SNPs:
rs33955261; rs1042602; rs1126809; rs1042608; rs4987234; rs3913543; rs3913544; rs1502267; rs3913542; rs1827430; rs1432447; rs12799137; rs2186640; rs12273884; rs6483004; rs11018524; rs12803764; rs621313; rs7358418; rs7117973; rs7929991; rs11018541; rs6483000; rs11820797; rs10765196; rs11824837; rs4753215; rs11018528; rs12420237; rs1393350; rs12804012; rs4399330; rs7108676; rs6483008; rs6483001; rs12419949; rs1939258; rs7940773; rs7945829; rs6483006; rs591260; rs574028; rs7929015; rs12419351; rs12808785; rs6483002; rs4396293; rs501301; rs3900053; rs11018530; rs7115192; rs6483007; rs7123654; rs7940760; rs10765197; rs9919559; rs3793974; rs16913104; rs1847142; rs7943909; rs16913107; rs7107143; rs17793750; rs7111110; rs12418383; rs1939253; rs4121403; rs7947262; rs2000554; rs12420674; rs12416719; rs1847134; rs12419364; rs7115568; rs11018525; rs12418646; rs7941532; rs11820635; rs7105390; rs12419262; rs16912259; rs6483003; rs2866556; rs12808381; rs7123206; rs3793976; rs10765200; rs10830241; rs12791412; rs12786274; rs16913039; rs2000553; rs7112373; rs7927996; rs7941110; rs12417182; rs12420662; rs11823675; rs10830250; rs7941686; rs12420278; rs4121401; rs7117190; rs12421397; rs4418813; rs12807810; rs12789914; rs10765198; rs10741305; rs12808354; rs12421155; rs12417077; rs12418148; rs11824443; rs10765201; rs2002720; rs1942493; rs12098971; rs12806466; rs7101897; rs1939255; rs2298458; rs17174064; rs7924589; rs11018544; rs10501700; rs12421402; rs12417632; rs3793975; rs7117826; rs10830253; rs17191474; rs12419341; rs12420348; rs594647; rs7129973; rs12280928; rs7117213; rs16912972; rs16912981; rs11018522; rs12417166; rs7103781; rs12280693; rs11820834; rs10830245; rs1939262; rs12799347; rs7933595; rs10830248; rs12808219; rs7942587; rs12421746; rs12574987; rs7940368; rs4601783; rs16913084; rs12420864; rs12419071; rs7116589; rs16913095; rs10501698; rs11018549; rs12416958; rs7925659; rs7358330; rs12270717; rs12365043; rs12421030; rs12577992; rs16912983; rs11018555; rs12793071; rs11018545; rs11018535; rs16912966; rs11828655; rs7947052; rs11828731; rs12795158; rs3936992; rs1939263; rs9919546; rs4290229; rs660491; rs10830240; rs7933594; rs16912262; rs7117255; rs11821815; rs575429; rs10830249; rs6482999; rs1074304; rs10830244; rs11018542; rs11018548; rs17793678; rs645592; rs11018553; rs12799516; rs598769; rs10765199; rs4087499; rs16913089; rs10501699; rs16913011; rs1939251; rs4753214; rs7935604; rs11018543; rs12421505; rs10830239; rs12417327; rs11018532; rs7939929; rs6415994; rs2000555; rs12795171; rs7925468; rs2155148; rs7103787; rs16913040; rs11018562; rs1939252; rs12286618; rs7116973; rs12363772; rs10830243; rs12808283; rs7943159; rs16912994; rs7116716; rs7936840; rs9736253; rs4512823; rs3936623; rs7929736; rs11018539; rs535527; rs2155149; rs2155147; rs12803765; rs877072; rs10830247; rs10830246; rs7934212; rs12417026; rs7117974; rs6485980; rs10830238; rs12799768; rs7924913; rs525883; rs12418178; rs12288824; rs12792733; rs12799349; rs4542415; rs12792959; rs1892924; rs4547091; rs1799989; rs5021654; rs7930949; rs7940945; rs28940878; rs13312744; rs13312739; rs34297847; rs34878847; rs13312741; rs28940880; rs11545463; rs13312740; rs11826502; rs11824499; rs11545464; rs28940877; rs28940879; rs36006590; rs28940876; rs28940881; rs13312743; rs1939261; rs1939260; rs35541275; rs1800421; rs13312738; rs34814690; rs11453031; rs36041295; rs1939254; rs7121593; rs34175287; rs7951381; rs11018554; rs35062445; rs34947445; rs34656455; rs11411684; rs28634864; rs11018559; rs11018540; rs34017963; rs34698766; rs2134299; rs12788302; rs35963892; rs12786392; rs11018547; rs36137175; rs1060297; rs34202080; rs12788985; rs12365772; rs12578000; rs35218219; rs12788993; rs11018560; rs4121402; rs35026809; rs35311585; rs4121397; rs5793396; rs17852431; rs36124916; rs7929045; rs4561218; rs34486762; rs34289520; rs35905469; rs34003066; rs4429061; rs34661861; rs4987235; rs12796520; rs34703992; rs28578270; rs34373463; rs11018523; rs34739346; rs12786829; rs905283; rs5793397; rs12277937; rs11018527; rs34899701; rs34429128; rs34758368; rs34773602; rs1074303; rs36055732; rs12803508; rs13312742; rs16913082; rs36007597; rs12804213; rs35654391; rs10526067; rs28620862; rs12791524; rs35555968; rs11018536; rs7396600; rs10551522; rs34876778; rs11018556; rs1783963; rs35928779; rs7946027; rs12786751; rs7924312; rs4079453; rs4087500; rs3907204; rs35930733; rs35724269; rs12804722; rs7934646; rs35477235; rs35801536; rs34425156; rs41320146; rs1939257; rs12789480; rs34675404; rs12805094; rs11018550; rs35501966; rs35514600; rs34903891; rs12803535; rs12294360; rs4512825; rs34634444; rs592486; rs17852430; rs35663695; rs10573250; rs12788260; rs35032790; rs34621048; rs12099254; rs34873297; rs694934; rs34700959; rs4611200; rs7127196; rs35103430; rs35217407; rs35464565; rs5793398; rs10547762; rs16913085; rs34422026; rs7928821; rs35222097; rs34604882; rs609630; rs12796336; rs10671315; rs35457014; rs12271965; rs7946211; rs12805443; rs35434176; rs12789834; rs4121400; rs12146614; rs35105852; rs3907205; rs35774080; rs35744603; rs1939256; rs35428928; rs648871; rs35937494; rs582480; rs12786390; rs625401; rs11018563; rs12797237; rs636613; rs12788232; rs12807511; rs35959534; rs34067617; rs36098386; rs12788214; rs35518533; rs7112858; rs5793399; rs34584385; rs35607520; rs11018557; rs12805030; rs12574349; rs2008320; rs516696; rs35526885; rs12805221; rs35342940; rs11018551; rs1847136; rs11018538; rs11018546; rs34530512; rs34857319; rs35029283; rs11018534; rs1074305; rs35523924; rs12789159; rs35300336; rs11517465; rs603082; rs34295137; rs28826427; rs34469199; rs12787683; rs35430241; rs35115224; rs35597809; rs12295166; rs4614456; rs905281; rs10583155; rs35770150; rs34754918; rs7924785; rs35581621; rs1987513; rs12786588; rs2173998; rs33998063; rs12285584; rs12805029; rs11381844; rs12099178; rs11018558; rs28625671; rs4121398; rs35531191; rs649687; rs7927845; rs34029150; rs35008750; rs7122606; rs475629; rs34865967; rs34625776; rs35549872; rs4121399; rs35764186; rs3834913; rs7483274; rs11018526; rs12786201; rs1939259; rs28625370; rs35804290; rs34388247; rs16912961; rs35195697; rs7105284; rs35638921; rs7119171; rs12364170; rs10691193; rs28521275; rs11374501; rs10830237; rs11824466; rs11827921; rs12795279; rs1954771; rs35402334; rs7949856; rs949537; rs949538

# Metabolic_Enzyme_1_General_References:
1903356; 2823263; 2499655; 1711223; 8340755; 11153699; 2480811; 2504160; 11214319; 8477259; 10094567; 2342539; 1970634; 1903591; 1642278; 1899321; 1900309; 1943686; 1487241; 7902671; 8128955; 7955413; 8644824; 9158138; 9259202; 10987646; 10571953; 11295837; 11858948

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5505

# Metabolic_Enzyme_2_Name:
Tyrosine 3-monooxygenase

# Metabolic_Enzyme_2_Synonyms:
Tyrosine 3-hydroxylase; TH

# Metabolic_Enzyme_2_Gene_Name:
TH

# Metabolic_Enzyme_2_Protein_Sequence:
>Tyrosine 3monooxygenase
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTP
RSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPR
ATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVR
QVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEI
AFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNI
PQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCC
HELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQNGEVKAYG
AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYAS
RIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG

# Metabolic_Enzyme_2_Number_of_Residues:
528

# Metabolic_Enzyme_2_Molecular_Weight:
58525

# Metabolic_Enzyme_2_Theoretical_pI:
6.25

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  tyrosine 3-monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  catecholamine metabolism
Process:  catecholamine biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Plays an important role in the physiology of adrenergic neurons

# Metabolic_Enzyme_2_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_2_Reaction:
L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00351:Biopterin_H

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.14.16.2

# Metabolic_Enzyme_2_GenBank_ID_Protein:
37127

# Metabolic_Enzyme_2_SwissProt_ID:
TY3H_HUMAN (P07101)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
TH

# Metabolic_Enzyme_2_Geneatlas_id:
TH

# Metabolic_Enzyme_2_hgnc_id:
HGNC:11782

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>1575 bp
ATGCCCACCCCCGACGCCACCACGCCACAGGCCAAGGGCTTCCGCAGGGCCGTGTCTGAG
CTGGACGCCAAGCAGGCAGAGGCCATCATGGGCGCCCCGGGGCCCAGCCTCACAGGCTCT
CCGTGGCCTGGAACTGCAGCCCCAGCTGCATCCTACACCCCCACCCCAAGGTCCCCGCGG
TTCATTGGGCGCAGGCAGAGCCTCATCGAGGACGCCCGCAAGGAGCGGGAGGCGGCGGTG
GCAGCAGCGGCCGCTGCAGTCCCCTCGGAGCCCGGGGACCCCCTGGAGGCTGTGGCCTTT
GAGGAGAAGGAGGGGAAGGCCGTGCTAAACCTGCTCTTCTCCCCGAGGGCCACCAAGCCC
TCGGCGCTGTCCCGAGCTGTGAAGGTGTTTGAGACGTTTGAAGCCAAAATCCACCATCTA
GAGACCCGGCCCGCCCAGAGGCCGCGAGCTGGGGGCCCCCACCTGGAGTACTTCGTGCGC
CTCGAGGTGCGCCGAGGGGACCTGGCCGCCCTGCTCAGTGGTGTGCGCCAGGTGTCAGAG
GACGTGCGCAGCCCCGCGGGGCCCAAGGTCCCCTGGTTCCCAAGAAAAGTGTCAGAGCTG
GACAAGTGTCATCACCTGGTCACCAAGTTCGACCCTGACCTGGACTTGGACCACCCGGGC
TTCTCGGACCAGGTGTACCGCCAGCGCAGGAAGCTGATTGCTGAGATCGCCTTCCAGTAC
AGGCACGGCGACCCGATTCCCCGTGTGGAGTACACCGCCGAGGAGATTGCCACCTGGAAG
GAGGTCTACACCACGCTGAAGGGCCTCTACGCCACGCACGCCTGCGGGGAGCACCTGGAG
GCCTTTGCTTTGCTGGAGCGCTTCAGCGGCTACCGGGAAGACAATATCCCCCAGCTGGAG
GACGTCTCCCGCTTCCTGAAGGAGCGCACGGGCTTCCAGCTGCGGCCTGTGGCCGGCCTG
CTGTCCGCCCGGGACTTCCTGGCCAGCCTGGCCTTCCGCGTGTTCCAGTGCACCCAGTAT
ATCCGCCACGCGTCCTCGCCCATGCACTCCCCTGAGCCGGACTGCTGCCACGAGCTGCTG
GGGCACGTGCCCATGCTGGCCGACCGCACCTTCGCGCAGTTCTCGCAGGACATTGGCCTG
GCGTCCCTGGGGGCCTCGGATGAGGAAATTGAGAAGCTGTCCACGCTGTCATGGTTCACG
GTGGAGTTCGGGCTGTGTAAGCAGAACGGGGAGGTGAAGGCCTATGGTGCCGGGCTGCTG
TCCTCCTACGGGGAGCTCCTGCACTGCCTGTCTGAGGAGCCTGAGATTCGGGCCTTCGAC
CCTGAGGCTGCGGCCGTGCAGCCCTACCAAGACCAGACGTACCAGTCAGTCTACTTCGTG
TCTGAGAGCTTCAGTGACGCCAAGGACAAGCTCAGGAGCTATGCCTCACGCATCCAGCGC
CCCTTCTCCGTGAAGTTCGACCCGTACACGCTGGCCATCGACGTGCTGGACAGCCCCCAG
GCCGTGCGGCGCTCCCTGGAGGGTGTCCAGGATGAGCTGGACACCCTTGCCCATGCGCTG
AGTGCCATTGGCTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
Y00414

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_2_Locus:
11p15.5

# Metabolic_Enzyme_2_SNPs:
rs6356; rs7950050; rs6357; rs34510659; rs11826260; rs3842725; rs10840489; rs11825601; rs4074905; rs12419447; rs2070762; rs7482510; rs3842722; rs7925924; rs7942881; rs11826130; rs7483805; rs7483056; rs4072826; rs4072824; rs7925375; rs7479936; rs4072823; rs3842723; rs10743149; rs10770140; rs3842727; rs7119275; rs7115640; rs10840490; rs10770141; rs11564711; rs10840491; rs3842726; rs11042962; rs10770142; rs28934581; rs28934579; rs28934580; rs1800033; rs36097848; rs3842724; rs1799833; rs11564716; rs34723540; rs6578990; rs11042950; rs3842721; rs35596265; rs11564713; rs11564712; rs36009557; rs4930043; rs36010304; rs7925784; rs35996457; rs4072825; rs35125951; rs11564714; rs35444567; rs34965351; rs11564715; rs11564717; rs10734659; rs11564718; rs1800032; rs10743152; rs10770143; rs10840447; rs10840452; rs10840495; rs10840496; rs10840502; rs11042965; rs11042966; rs11042971; rs11042976; rs11042978; rs11042982; rs11042984; rs11042987; rs11564709; rs11564710; rs11564720; rs2000993; rs28494588; rs28933985; rs3842733; rs3842738; rs3842741; rs3842748; rs3842752; rs3842753; rs3842754; rs3842756; rs3842768; rs3842769; rs3842770; rs3842775; rs4929964; rs4929966; rs4930046; rs5505; rs5506; rs5507; rs6578993; rs689; rs7110099; rs7128097; rs7482891; rs7936868

# Metabolic_Enzyme_2_General_References:
2882428; 2888085; 2887169; 2902075; 2892893; 2896667; 7814018; 7789962; 8528210; 8817341; 9613851; 9754624; 9703425; 10391209; 11246459

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5510

# Metabolic_Enzyme_3_Name:
Aromatic-L-amino-acid decarboxylase

# Metabolic_Enzyme_3_Synonyms:
AADC; DOPA decarboxylase; DDC

# Metabolic_Enzyme_3_Gene_Name:
DDC

# Metabolic_Enzyme_3_Protein_Sequence:
>AromaticLaminoacid decarboxylase
MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV
EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD
WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM
EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV
ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN
PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL
KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN
EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE


# Metabolic_Enzyme_3_Number_of_Residues:
480

# Metabolic_Enzyme_3_Molecular_Weight:
53895

# Metabolic_Enzyme_3_Theoretical_pI:
7.21

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
 ||
>>>
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine

# Metabolic_Enzyme_3_Pathway:
map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00901  Indole and ipecac alkaloid biosynthesis;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_3_Reaction:
L-tryptophan = tryptamine + CO2

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00282:Pyridoxal_deC

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 4.1.1.28

# Metabolic_Enzyme_3_GenBank_ID_Protein:
181521

# Metabolic_Enzyme_3_SwissProt_ID:
DDC_HUMAN (P20711)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
DDC

# Metabolic_Enzyme_3_Geneatlas_id:
DDC

# Metabolic_Enzyme_3_hgnc_id:
HGNC:2719

# Metabolic_Enzyme_3_PDB_ID:
1JS3

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>1443 bp
ATGAACGCAAGTGAATTCCGAAGGAGAGGGAAGGAGATGGTGGATTACGTGGCCAACTAC
ATGGAAGGCATTGAGGGACGCCAGGTCTACCCTGACGTGGAGCCCGGGTACCTGCGGCCG
CTGATCCCTGCCGCTGCCCCTCAGGAGCCAGACACGTTTGAGGACATCATCAACGACGTT
GAGAAGATAATCATGCCTGGGGTGACGCACTGGCACAGCCCCTACTTCTTCGCCTACTTC
CCCACTGCCAGCTCGTACCCGGCCATGCTTGCGGACATGCTGTGCGGGGCCATTGGCTGC
ATCGGCTTCTCCTGGGCGGCAAGCCCAGCATGCACAGAGCTGGAGACTGTGATGATGGAC
TGGCTCGGGAAGATGCTGGAACTACCAAAGGCATTTTTGAATGAGAAAGCTGGAGAAGGG
GGAGGAGTGATCCAGGGAAGTGCCAGTGAAGCCACCCTGGTGGCCCTGCTGGCCGCTCGG
ACCAAAGTGATCCATCGGCTGCAGGCAGCGTCCCCAGAGCTCACACAGGCCGCTATCATG
GAGAAGCTGGTGGCTTACTCATCCGATCAGGCACACTCCTCAGTGGAAAGAGCTGGGTTA
ATTGGTGGAGTGAAATTAAAAGCCATCCCCTCAGATGGCAACTTCGCCATGCGTGCGTCT
GCCCTGCAGGAAGCCCTGGAGAGAGACAAAGCGGCTGGCCTGATTCCTTTCTTTATGGTT
GCCACCCTGGGGACCACAACATGCTGCTCCTTTGACAATCTCTTAGAAGTCGGTCCTATC
TGCAACAAGGAAGACATATGGCTGCACGTTGATGCAGCCTACGCAGGCAGTGCATTCATC
TGCCCTGAGTTCCGGCACCTTCTGAATGGAGTGGAGTTTGCAGATTCATTCAACTTTAAT
CCCCACAAATGGCTATTGGTGAATTTTGACTGTTCTGCCATGTGGGTGAAAAAGAGAACA
GACTTAACGGGAGCCTTTAGACTGGACCCCACTTACCTGAAGCACAGCCATCAGGATTCA
GGGCTTATCACTGACTACCGGCATTGGCAGATACCACTGGGCAGAAGATTTCGCTCTTTG
AAAATGTGGTTTGTATTTAGGATGTATGGAGTCAAAGGACTGCAGGCTTATATCCGCAAG
CATGTCCAGCTGTCCCATGAGTTTGAGTCACTGGTGCGCCAGGATCCCCGCTTTGAAATC
TGTGTGGAAGTCATTCTGGGGCTTGTCTGCTTTCGGCTAAAGGGTTCCAACAAAGTGAAT
GAAGCTCTTCTGCAAAGAATAAACAGTGCCAAAAAAATCCACTTGGTTCCATGTCACCTC
AGGGACAAGTTTGTCCTGCGCTTTGCCATCTGTTCTCGCACGGTGGAATCTGCCCATGTG
CAGCGGGCCTGGGAACACATCAAAGAGCTGGCGGCCGACGTGCTGCGAGCAGAGAGGGAG
TAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M76180

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_3_Locus:
7p11

# Metabolic_Enzyme_3_SNPs:
rs6263; rs6262; rs11575542; rs11575292; rs6264; rs11575302; rs11575290; rs921451; rs2329342; rs2329371; rs10499694; rs1451374; rs10276473; rs6949897; rs4452748; rs921450; rs7803440; rs7803788; rs1470747; rs1451375; rs6969081; rs1966839; rs7803903; rs10249420; rs1451373; rs10265930; rs10499695; rs7786398; rs11575548; rs11974297; rs10250513; rs11575551; rs1349491; rs11575549; rs2060762; rs11575288; rs2329341; rs2329343; rs11575286; rs11575550; rs6593002; rs3779074; rs2242041; rs3837091; rs2329340; rs11765748; rs3779075; rs2044859; rs10499696; rs7779110; rs2876830; rs2242042; rs3779076; rs4947644; rs11765109; rs930707; rs11575282; rs11575273; rs17133881; rs4585697; rs11575544; rs17133878; rs10255505; rs11575281; rs6956737; rs11575543; rs11575545; rs2060761; rs11575553; rs6962356; rs11575546; rs10229387; rs11575552; rs11575284; rs11575280; rs6972476; rs11575547; rs6975312; rs998850; rs730092; rs896309; rs880028; rs1376524; rs745043; rs6592962; rs10899734; rs7790758; rs3887825; rs3735274; rs6965432; rs4948196; rs11761683; rs11238134; rs10899735; rs1451371; rs3807556; rs4947580; rs6951323; rs6950777; rs4580999; rs9942686; rs10277662; rs4947584; rs2198144; rs6592961; rs3779078; rs11983581; rs1037351; rs4436083; rs1901312; rs3807552; rs11983757; rs1451372; rs2167364; rs11772714; rs4947577; rs11575457; rs11768267; rs11575334; rs3735273; rs7809758; rs11575320; rs11980368; rs4377912; rs6957607; rs4947582; rs7776816; rs11981575; rs11575464; rs4948201; rs6967361; rs1451370; rs11575536; rs6944090; rs17133853; rs2876827; rs11575340; rs10244632; rs11575489; rs6592952; rs6952023; rs10228056; rs896308; rs11974997; rs11575518; rs4602840; rs11575378; rs11575527; rs11575375; rs12718541; rs11575387; rs745042; rs1817074; rs4579483; rs7791875; rs2122822; rs11575399; rs11575511; rs4947535; rs11575351; rs1376523; rs4992502; rs6947293; rs11575435; rs11575407; rs11575338; rs11575516; rs11763837; rs11575400; rs17133842; rs11575520; rs7777600; rs4397355; rs1901311; rs10274275; rs11575451; rs11575538; rs4948197; rs11575388; rs4947634; rs12667533; rs10268819; rs11575441; rs11575506; rs3779084; rs6974583; rs17133877; rs12718527; rs3807566; rs6979229; rs11238138; rs10499693; rs11982708; rs1982406; rs2329367; rs2100280; rs11238133; rs3807555; rs11575461; rs2876829; rs7803247; rs10899736; rs6951648; rs1007702; rs11575500; rs11771818; rs11575444; rs11575541; rs4329234; rs11575442; rs10239830; rs9918702; rs11575501; rs1007749; rs11575494; rs4947576; rs11575523; rs7780360; rs6963534; rs11982772; rs11575309; rs4947581; rs11575462; rs1349492; rs732215; rs11575322; rs2329365; rs10271341; rs4989851; rs3807558; rs11575298; rs4433100; rs11575537; rs731689; rs4490786; rs4245549; rs896307; rs17634958; rs3757472; rs4470989; rs11238131; rs11575535; rs11982776; rs7808025; rs3807562; rs11575404; rs2122817; rs11575522; rs6592963; rs5884156; rs3807553; rs10249982; rs11575510; rs1470750; rs4947631; rs11575463; rs12718572; rs12535024; rs2329366; rs11575383; rs6955487; rs2122821; rs17665398; rs11765543; rs7809477; rs12538938; rs11575327; rs11575521; rs1451369; rs12112308; rs11575360; rs17553495; rs11575454; rs1817073; rs11575447; rs2167367; rs3823674; rs11575450; rs11575507; rs11575319; rs11575301; rs17152014; rs10239937; rs6970468; rs11575295; rs7785224; rs4947621; rs17733244; rs3470; rs4449741; rs11575532; rs11575460; rs2167366; rs17634717; rs3779083; rs11575423; rs11575504; rs880029; rs17553791; rs6952381; rs11575502; rs9918591; rs11575406; rs11771860; rs11575519; rs1451368; rs2122818; rs11575372; rs11575343; rs11575300; rs11575368; rs11575381; rs13222408; rs11575509; rs12718574; rs11575455; rs11575540; rs11768997; rs7797142; rs17635123; rs7792578; rs11575515; rs11575526; rs11575491; rs11767384; rs6953675; rs7807564; rs11575385; rs2329364; rs11575332; rs11575512; rs11575296; rs12665948; rs11575428; rs11575305; rs11575323; rs11575503; rs11575339; rs11575449; rs6964142; rs2122819; rs11575304; rs2876826; rs11575342; rs11767334; rs11575456; rs17152020; rs11575472; rs4948225; rs11575313; rs3807563; rs7792474; rs11575525; rs11978797; rs10267323; rs2329368; rs11575424; rs2100279; rs11575434; rs6963996; rs11575513; rs11575534; rs11763051; rs11575411; rs11575392; rs11575425; rs11575505; rs11575328; rs17665588; rs11575431; rs4947625; rs6592969; rs11575349; rs11575353; rs2060763; rs12718528; rs11575293; rs11575492; rs6944912; rs11575356; rs2329369; rs11575429; rs11575438; rs7802199; rs3887826; rs11575453; rs11575414; rs11575321; rs2876828; rs12535064; rs7812167; rs6592973; rs11575508; rs1807066; rs1304691; rs11575437; rs11575514; rs17634771; rs1466163; rs11575374; rs7809234; rs3779082; rs11575430; rs12671474; rs11575422; rs7810677; rs3071970; rs11575446; rs11575410; rs11575325; rs2167363; rs17665670; rs13311361; rs11575352; rs11575483; rs11575413; rs7778349; rs6975453; rs11575359; rs12718529; rs1451366; rs11575531; rs11575493; rs1597639; rs11575528; rs4948010; rs4947510; rs3829897; rs11575575; rs6593010; rs11575557; rs4947511; rs11575565; rs11575568; rs11575564; rs11575574; rs11575266; rs10278338; rs11575562; rs11575259; rs11575264; rs11575561; rs11575570; rs11575271; rs11575566; rs11575569; rs11575267; rs11575556; rs11575268; rs11575376; rs11575377; rs11575291; rs12670911; rs10233346; rs11575274; rs28607134; rs28799122; rs34618339; rs13223166; rs11302809; rs4515495; rs10281167; rs34752519; rs2242040; rs13223157; rs13233973; rs13245496; rs2242039; rs5884158; rs13237075; rs2329370; rs28510954; rs10600316; rs10229102; rs13226079; rs3071145; rs11366731; rs10601831; rs35197006; rs7791943; rs2242038; rs5014165; rs13226287; rs7782081; rs12718674; rs11575276; rs2167368; rs10255145; rs11575277; rs34606153; rs6975015; rs11410259; rs10229369; rs10247443; rs11575275; rs10609620; rs7787209; rs13245018; rs34348593; rs1988550; rs35330002; rs35591152; rs11450560; rs11575468; rs34658291; rs11575395; rs35299591; rs34021747; rs35586188; rs11575432; rs34314851; rs35089176; rs35997922; rs12537169; rs12718558; rs11575294; rs1470749; rs11315611; rs11575315; rs13228083; rs35582115; rs4947588; rs13308328; rs3779077; rs3807554; rs5884157; rs7811992; rs12718563; rs36110443; rs11575482; rs11330628; rs1107742; rs731690; rs11575433; rs4948216; rs11575311; rs11575326; rs6965025; rs11575347; rs11575474; rs11575316; rs11575459; rs35993062; rs3840579; rs11575314; rs11575465; rs5884154; rs3779080; rs34950596; rs2198143; rs10718396; rs10587155; rs36090705; rs34869137; rs11575533; rs3071964; rs13234331; rs34002033; rs1137337; rs34977933; rs3779081; rs35173748; rs1470748; rs12538830; rs4947594; rs11575497; rs35008528; rs4947589; rs2084723; rs11575306; rs34971815; rs34780941; rs13222708; rs11575346; rs1107743; rs6953661; rs12718583; rs11575329; rs6959596; rs36104801; rs7794360; rs11763809; rs13244875; rs11575362; rs11575415; rs28889020; rs35666388; rs35765995; rs6968322; rs11575389; rs11761208; rs33974864; rs6975747; rs13232900; rs34329145; rs11575369; rs7810684; rs11978769; rs4143196; rs28706313; rs3071975; rs7781950; rs28534613; rs12718611; rs4377913; rs1580031; rs5884155; rs28531762; rs34984600; rs11309882; rs11575318; rs35539624; rs11575333; rs36063027; rs11980236; rs7785984; rs35432113; rs34298125; rs11575363; rs7455902; rs7786752; rs10258321; rs34582666; rs11575397; rs11575530; rs4455783; rs11575529; rs11575312; rs33945116; rs4948205; rs1304693; rs11575401; rs35915381; rs2122820; rs34487683; rs11763807; rs13225182; rs6960966; rs34791889; rs36005269; rs11575303; rs6952938; rs6964313; rs10710723; rs11575417; rs1901313; rs11378977; rs11575524; rs11575394; rs13229021; rs11575308; rs11575348; rs12666643; rs11575499; rs35269833; rs11575393; rs11575330; rs4052336; rs3071963; rs11575458; rs11575367; rs13228086; rs35484306; rs7793185; rs11575390; rs12537186; rs35092758; rs3807557; rs11575555; rs11575554; rs11575269; rs11575567; rs11575257; rs11575559; rs11575265; rs11575261; rs11575571; rs11575270; rs11575572; rs35937247; rs11575260; rs4947662; rs13243080; rs11575563; rs35517528; rs10499697; rs11238214; rs11489734; rs11977135; rs12666409; rs13228274; rs3911193; rs4947396; rs6593011; rs7790230; rs7804365; rs7807335; rs978784

# Metabolic_Enzyme_3_General_References:
2590185; 1612608; 1540578; 8510497; 1395716; 10391209

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5504

# Metabolic_Enzyme_4_Name:
Catechol O-methyltransferase

# Metabolic_Enzyme_4_Synonyms:
Not Available

# Metabolic_Enzyme_4_Gene_Name:
COMT

# Metabolic_Enzyme_4_Protein_Sequence:
>Catechol Omethyltransferase
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRIL
NHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCG
YSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKY
DVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFE
CTHYQSFLEYREVVDGLEKAIYKGPGSEAGP

# Metabolic_Enzyme_4_Number_of_Residues:
271

# Metabolic_Enzyme_4_Molecular_Weight:
30037

# Metabolic_Enzyme_4_Theoretical_pI:
5.15

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  O-methyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol

# Metabolic_Enzyme_4_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_4_Reaction:
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01596:Methyltransf_3

# Metabolic_Enzyme_4_Signals:
1-32

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.1.1.6

# Metabolic_Enzyme_4_GenBank_ID_Protein:
180920

# Metabolic_Enzyme_4_SwissProt_ID:
COMT_HUMAN (P21964)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
COMT

# Metabolic_Enzyme_4_Geneatlas_id:
COMT

# Metabolic_Enzyme_4_hgnc_id:
HGNC:2228

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Isoform S-COMT:Cytoplasm. Isoform MB-COMT:Cell membrane; single-pass type II membrane protein; extracellular side

# Metabolic_Enzyme_4_Gene_Sequence:
>816 bp
ATGCCGGAGGCCCCGCCTCTGCTGTTGGCAGCTGTGTTGCTGGGCCTGGTGCTGCTGGTG
GTGCTGCTGCTGCTTCTGAGGCACTGGGGCTGGGGCCTGTGCCTTATCGGCTGGAACGAG
TTCATCCTGCAGCCCATCCACAACCTGCTCATGGGTGACACCAAGGAGCAGCGCATCCTG
AACCACGTGCTGCAGCATGCGGAGCCCGGGAACGCACAGAGCGTGCTGGAGGCCATTGAC
ACCTACTGCGAGCAGAAGGAGTGGGCCATGAACGTGGGCGACAAGAAAGGCAAGATCGTG
GACGCCGTGATTCAGGAGCACCAGCCCTCCGTGCTGCTGGAGCTGGGGGCCTACTGTGGC
TACTCAGCTGTGCGCATGGCCCGCCTGCTGTCACCAGGGGCGAGGCTCATCACCATCGAG
ATCAACCCCGACTGTGCCGCCATCACCCAGCGGATGGTGGATTTCGCTGGCGTGAAGGAC
AAGGTCACCCTTGTGGTTGGAGCGTCCCAGGACATCATCCCCCAGCTGAAGAAGAAGTAT
GATGTGGACACACTGGACATGGTCTTCCTCGACCACTGGAAGGACCGGTACCTGCCGGAC
ACGCTTCTCTTGGAGGAATGTGGCCTGCTGCGGAAGGGGACAGTGCTACTGGCTGACAAC
GTGATCTGCCCAGGTGCGCCAGACTTCCTAGCACACGTGCGCGGGAGCAGCTGCTTTGAG
TGCACACACTACCAATCGTTCCTGGAATACAGGGAGGTGGTGGACGGCCTGGAGAAGGCC
ATCTACAAGGGCCCAGGCAGCGAAGCAGGGCCCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M65212

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_4_Locus:
22q11.21-q11.23|22q11.21

# Metabolic_Enzyme_4_SNPs:
rs5031015; rs6267; rs4680; rs13306279; rs13306281; rs6270; rs740602; rs8192488; rs4818; rs769223; rs769224; rs165631; rs4633; rs6269; rs739368; rs165656; rs4646312; rs5992501; rs7287550; rs165722; rs5746849; rs11569715; rs740603; rs9332380; rs7290221; rs174674; rs9332351; rs3810595; rs174675; rs5993887; rs9332361; rs6518593; rs174680; rs9332356; rs5993882; rs11569716; rs3087869; rs9332325; rs174673; rs174678; rs5993883; rs933271; rs9332359; rs165767; rs9332347; rs8185002; rs5993879; rs9332363; rs174691; rs9332332; rs5992500; rs174682; rs9332346; rs13306280; rs362204; rs174688; rs9332342; rs11569717; rs174695; rs5993881; rs7291003; rs1544325; rs9332331; rs3819621; rs174684; rs34798238; rs174677; rs174690; rs9606196; rs174693; rs11912353; rs12053782; rs11913025; rs36111598; rs5993888; rs9332362; rs174685; rs34438295; rs5992499; rs34691071; rs9332357; rs174692; rs9332334; rs3838146; rs9332333; rs9332352; rs35014456; rs35527466; rs35558779; rs11704299; rs9332350; rs6268; rs34450201; rs9680656; rs1055503; rs11912354; rs11089323; rs5993884; rs16982842; rs174679; rs9332353; rs34300220; rs9332358; rs9332360; rs34937293; rs34966851; rs174676; rs16982844; rs5844402; rs9332323; rs35919169; rs174683; rs35777291; rs9332348; rs8140865; rs34686565; rs165737; rs4646315; rs2239393; rs165774; rs9306235; rs740601; rs5993889; rs9306234; rs4646316; rs8140835; rs4646317; rs9332370; rs174697; rs174696; rs9332377; rs4646318; rs1109436; rs9332368; rs3218737; rs34068292; rs9332369; rs9332364; rs9332372; rs9332367; rs9332365; rs4646313; rs34446512; rs34819182; rs174699; rs34234839; rs165895; rs165599; rs9332381; rs35478083; rs36082074; rs11544670; rs4986871; rs11544669; rs165879; rs35791904; rs35788262; rs13054814; rs5992498; rs5748490; rs361698; rs28600912; rs9605040; rs11703339; rs9332319; rs174689; rs9606193; rs5844403; rs9332340; rs34778315; rs11703340; rs5993886; rs14968; rs9332344; rs28621910; rs3081743; rs174681; rs361549; rs35280052; rs361708; rs12167365; rs2004497; rs12170804; rs35357972; rs9332321; rs361574; rs9332328; rs35920235; rs9332337; rs5993880; rs12814; rs9332343; rs11544667; rs9606195; rs9332349; rs11296030; rs5748492; rs9332354; rs34029447; rs35188675; rs3819619; rs8136901; rs35094299; rs9332322; rs28804429; rs174687; rs9332339; rs11912495; rs35617967; rs9332327; rs9332336; rs3841769; rs12167215; rs362253; rs9332338; rs35689277; rs11703069; rs174686; rs12168881; rs9606194; rs361699; rs9332355; rs3081741; rs5746850; rs9617852; rs28565095; rs13306277; rs174698; rs9332373; rs9332374; rs9332366; rs13054356; rs35819339; rs11460758; rs4646314; rs34016976; rs2904564; rs12158230; rs13055002; rs9332375; rs28562050; rs9332378; rs9332371; rs9332376; rs10427781; rs10427983; rs10483103; rs1110477; rs1110478; rs1110479; rs12165997; rs12169508; rs12627876; rs165655; rs165728; rs165815; rs165824; rs165840; rs165849; rs1800749; rs2020917; rs2073749; rs2239394; rs2239395; rs2240713; rs2240714; rs2240715; rs2240718; rs2518823; rs2518824; rs2871047; rs34134422; rs35219372; rs3788319; rs3788320; rs4646310; rs5746846; rs5746847; rs5748483; rs5748484; rs5993890; rs5993891; rs7288060; rs737864; rs737865; rs737866; rs758373; rs8140265; rs887199; rs887200; rs9265; rs9332314; rs9332315; rs9605030; rs9605031; rs9606186; rs9606189; rs9606201; rs9618716

# Metabolic_Enzyme_4_General_References:
1707278; 1847521; 8055944; 1993083; 1765063; 8807664; 10391209

# Metabolic_Enzyme_4_References:
15354384; 15365141; 15378229; 15390046

# Metabolic_Enzyme_5_ID:
5393

# Metabolic_Enzyme_5_Name:
Amine oxidase [flavin-containing] B

# Metabolic_Enzyme_5_Synonyms:
Monoamine oxidase type B; MAO-B

# Metabolic_Enzyme_5_Gene_Name:
MAOB

# Metabolic_Enzyme_5_Protein_Sequence:
>Amine oxidase flavincontaining 
BMSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGS
YVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFW
RTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHE
VSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYID
QTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIV
YYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEE
RLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVD
RIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITT
TFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV

# Metabolic_Enzyme_5_Number_of_Residues:
520

# Metabolic_Enzyme_5_Molecular_Weight:
58764

# Metabolic_Enzyme_5_Theoretical_pI:
7.55

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine

# Metabolic_Enzyme_5_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_5_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01593:Amino_oxidase

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
490-516

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.4.3.4

# Metabolic_Enzyme_5_GenBank_ID_Protein:
398415

# Metabolic_Enzyme_5_SwissProt_ID:
AOFB_HUMAN (P27338)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
MAOB

# Metabolic_Enzyme_5_Geneatlas_id:
MAOB

# Metabolic_Enzyme_5_hgnc_id:
HGNC:6834

# Metabolic_Enzyme_5_PDB_ID:
2BK3

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type IV membrane protein; cytoplasmic side

# Metabolic_Enzyme_5_Gene_Sequence:
>1560 bp
ATGAGCAACAAATGCGACGTGGTCGTGGTGGGGGGCGGCATCTCAGGTATGGCAGCAGCC
AAACTTCTGCATGACTCTGGACTGAATGTGGTTGTTCTGGAAGCCCGGGACCGTGTGGGA
GGCAGGACTTACACTCTTAGGAACCAAAAGGTTAAATATGTGGACCTTGGAGGATCCTAT
GTTGGACCAACCCAGAATCGTATCTTGAGATTAGCCAAGGAGCTAGGATTGGAGACCTAC
AAAGTGAATGAGGTTGAGCGTCTGATCCACCATGTAAAGGGCAAATCATACCCCTTCAGG
GGGCCATTCCCACCTGTATGGAATCCAATTACCTACTTAGATCATAACAACTTTTGGAGG
ACAATGGATGACATGGGGCGAGAGATTCCGAGTGATGCCCCATGGAAGGCTCCCCTTGCA
GAAGAGTGGGACAACATGACAATGAAGGAGCTACTGGACAAGCTCTGCTGGACTGAATCT
GCAAAGCAGCTTGCCACTCTCTTTGTGAACCTGTGTGTCACTGCAGAGACCCATGAGGTC
TCTGCTCTCTGGTTCCTGTGGTATGTGAAGCAGTGTGGAGGCACAACAAGAATCATCTCG
ACAACAAATGGAGGACAGGAGAGGAAATTTGTGGGCGGATCTGGTCAAGTGAGTGAGCGG
ATAATGGACCTCCTTGGAGACCGAGTGAAGCTGGAGAGGCCTGTGATCTACATTGACCAG
ACAAGAGAAAATGTCCTTGTGGAGACCCTAAACCATGAGATGTATGAGGCTAAATATGTG
ATTAGTGCTATTCCTCCTACTCTGGGCATGAAGATTCACTTCAATCCCCCTCTGCCAATG
ATGAGAAACCAGATGATCACTCGTGTGCCTTTGGGTTCAGTCATCAAGTGTATAGTTTAT
TATAAAGAGCCTTTCTGGAGGAAAAAGGATTACTGTGGAACCATGATTATTGATGGAGAA
GAAGCTCCAGTTGCCTACACGTTGGATGATACCAAACCTGAAGGCAACTATGCTGCCATA
ATGGGATTTATCCTGGCCCACAAAGCCAGAAAACTGGCACGTCTTACCAAAGAGGAAAGG
TTGAAGAAACTTTGTGAACTCTATGCCAAGGTTCTGGGTTCCCTAGAAGCTCTGGAGCCA
GTGCATTATGAAGAAAAGAACTGGTGTGAGGAGCAGTACTCTGGGGGCTGCTACACAACT
TATTTCCCCCCTGGGATCCTGACTCAATATGGAAGGGTTCTACGCCAGCCAGTGGACAGG
ATTTACTTTGCAGGCACCGAGACTGCCACACACTGGAGCGGCTACATGGAGGGGGCTGTA
GAGGCCGGGGAGAGAGCAGCCCGAGAGATCCTGCATGCCATGGGGAAGATTCCAGAGGAT
GAAATCTGGCAGTCAGAACCAGAGTCTGTGGATGTCCCTGCACAGCCCATCACCACCACC
TTTTTGGAGAGACATTTGCCCTCCGTGCCAGGCCTGCTCAGGCTGATTGGATTGACCACC
ATCTTTTCAGCAACGGCTCTTGGCTTCCTGGCCCACAAAAGGGGGCTACTTGTGAGAGTC


# Metabolic_Enzyme_5_GenBank_ID_Gene:
S62734

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_5_Locus:
Xp11.23

# Metabolic_Enzyme_5_SNPs:
rs7879356; rs6324; rs12010260; rs2072745; rs17462; rs3027440; rs7066677; rs3027439; rs1799836; rs3027453; rs2311013; rs3027441; rs5905512; rs3027459; rs2239450; rs2239441; rs7890174; rs5952297; rs3027444; rs5952330; rs7883073; rs5952671; rs6520902; rs2239449; rs6651806; rs3027454; rs7057075; rs12394221; rs2238969; rs12008119; rs7888450; rs12388038; rs2283727; rs12013965; rs17310637; rs12008438; rs5952294; rs5952340; rs12008548; rs12014398; rs1014876; rs3027449; rs2283730; rs2283729; rs5952813; rs6520901; rs5952352; rs2205655; rs10521432; rs6610856; rs12006628; rs3027450; rs6610853; rs2283731; rs3027456; rs2283728; rs9887326; rs5952325; rs3027442; rs7879586; rs12389168; rs3817729; rs12851487; rs5952686; rs3736672; rs2056913; rs1569424; rs7053203; rs2092042; rs7876594; rs12010996; rs3027457; rs9887047; rs3027451; rs17146716; rs7061798; rs3027464; rs6609259; rs3027446; rs736944; rs2239442; rs6609260; rs7067187; rs3027466; rs12558324; rs7888462; rs3027452; rs2092040; rs4824562; rs17146721; rs7884044; rs3027461; rs12389234; rs12007768; rs17244906; rs5952795; rs17146719; rs5905449; rs5952799; rs12394863; rs3027458; rs3027443; rs9698576; rs2092041; rs7892217; rs7061088; rs12689868; rs7067027; rs3027448; rs12558614; rs7057957; rs1040398; rs1040400; rs3027435; rs1181252; rs1040399; rs3027434; rs17852046; rs12850496; rs12845773; rs17856663; rs12845783; rs5952696; rs3191382; rs1181251; rs35285191; rs1051000; rs1803940; rs3027438; rs1051003; rs1050990; rs4339787; rs28530533; rs3027468; rs5952754; rs5952690; rs12558961; rs12852985; rs34468176; rs2311012; rs5905428; rs34165496; rs34825602; rs7892394; rs5952812; rs11091124; rs5906017; rs28522648; rs5952677; rs11282093; rs5906045; rs3838196; rs3027455; rs28667959; rs3027463; rs35676271; rs12841775; rs35574902; rs3027447; rs28657720; rs6610848; rs28531879; rs4824563; rs6610854; rs7060566; rs12396954; rs3027469; rs35687186; rs5952736; rs35375952; rs7057164; rs34716997; rs7062993; rs7063171; rs11412800; rs6651629; rs12845848; rs12853563; rs12012179; rs28368734; rs12115950; rs35968321; rs3027460; rs12394356; rs35439218; rs36085366; rs34265248; rs35762562; rs2239451; rs34292051; rs3027445; rs11320541; rs10481834; rs12845568; rs4592179; rs3216388; rs34945383; rs34220802; rs6610855; rs34261731; rs28485908; rs7888867; rs11431011; rs4071606; rs12390352; rs10567219; rs35520175; rs28527225; rs36068670; rs5952687; rs7888857; rs5952777; rs34822523; rs12010683; rs7883563; rs5952814; rs36209687; rs5952751; rs2238970; rs5952744; rs35797631; rs12389578; rs7474005; rs3027465; rs5952768; rs5906031; rs28636832; rs34252524; rs7058426; rs12391346; rs12689072; rs35943983; rs12395246; rs11414517; rs3027467; rs12013925; rs3736671; rs28421767; rs7058949; rs35634965; rs28754429; rs1894610; rs36102775; rs9887081; rs5952817; rs12855578; rs10658111; rs7062575; rs4620438; rs28568938; rs35291347; rs11797733; rs35054600; rs5952335; rs3027462; rs5952712; rs34752122; rs3054011; rs3027437; rs28577261; rs3027433; rs3761584; rs3027436; rs3027432; rs12558036; rs3027418; rs3027419; rs3027420; rs3027421; rs3027423; rs3027424; rs3027425; rs3027426; rs3027427; rs3027428; rs3027429; rs3027430; rs3027431; rs4351544; rs7884135; rs7890899

# Metabolic_Enzyme_5_General_References:
2023912; 3387449; 8515265; 1432104; 11049757; 11753429

# Metabolic_Enzyme_5_References:
15298067; 16425668; 16897138; 17007976

# Metabolic_Enzyme_6_ID:
6226

# Metabolic_Enzyme_6_Name:
GTP cyclohydrolase I

# Metabolic_Enzyme_6_Synonyms:
GTP-CH-I

# Metabolic_Enzyme_6_Gene_Name:
GCH1

# Metabolic_Enzyme_6_Protein_Sequence:
>GTP cyclohydrolase 
IMEKGPVRAPAEKPRGARCSNGFPERDPPRPGPSRPAEKPPRPEAKSAQPADGWKGERPR
SEEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKGYQETISDVLND
AIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRL
QVQERLTKQIAVAITEALRPAGVGVVVEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPK
TREEFLTLIRS

# Metabolic_Enzyme_6_Number_of_Residues:
250

# Metabolic_Enzyme_6_Molecular_Weight:
27903

# Metabolic_Enzyme_6_Theoretical_pI:
8.82

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  cyclohydrolase activity
Function:  GTP cyclohydrolase activity
Function:  GTP cyclohydrolase I activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown

# Metabolic_Enzyme_6_Pathway:
map00790  Folate biosynthesis

# Metabolic_Enzyme_6_Reaction:
GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF01227:GTP_cyclohydroI

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.5.4.16

# Metabolic_Enzyme_6_GenBank_ID_Protein:
7242659

# Metabolic_Enzyme_6_SwissProt_ID:
GCH1_HUMAN (P30793)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
GCH1

# Metabolic_Enzyme_6_Geneatlas_id:
GCH1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:4193

# Metabolic_Enzyme_6_PDB_ID:
1IS8

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_6_Gene_Sequence:
>753 bp
ATGGAGAAGGGCCCTGTGCGGGCACCGGCGGAGAAGCCGCGGGGCGCCAGGTGCAGCAAT
GGGTTCCCCGAGCGGGATCCGCCGCGGCCCGGGCCCAGCAGGCCGGCGGAGAAGCCCCCG
CGGCCCGAGGCCAAGAGCGCGCAGCCCGCGGACGGCTGGAAGGGCGAGCGGCCCCGCAGC
GAGGAGGATAACGAGCTGAACCTCCCTAACCTGGCAGCCGCCTACTCGTCCATCCTGAGC
TCGCTGGGCGAGAACCCCCAGCGGCAAGGGCTGCTCAAGACGCCCTGGAGGGCGGCCTCG
GCCATGCAGTTCTTCACCAAGGGCTACCAGGAGACCATCTCAGATGTCCTAAACGATGCT
ATATTTGATGAAGATCATGATGAGATGGTGATTGTGAAGGACATAGACATGTTTTCCATG
TGTGAGCATCACTTGGTTCCATTTGTTGGAAAGGTCCATATTGGTTATCTTCCTAACAAG
CAAGTCCTTGGCCTCAGCAAACTTGCGAGGATTGTAGAAATCTATAGTAGAAGACTACAA
GTTCAGGAGCGCCTTACAAAACAAATTGCTGTAGCAATCACGGAAGCCTTGCGGCCTGCT
GGAGTCGGGGTAGTGGTTGAAGCAACACACATGTGTATGGTAATGCGAGGTGTACAGAAA
ATGAACAGCAAAACTGTGACCAGCACAATGTTGGGTGTGTTCCGGGAGGATCCAAAGACT
CGGGAAGAGTTCCTGACTCTCATTAGGAGCTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
Z29434

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_6_Locus:
14q22.1-q22.2

# Metabolic_Enzyme_6_SNPs:
rs841; rs17128017; rs6572984; rs10136966; rs2878168; rs8004018; rs2183081; rs8007201; rs8004445; rs4411417; rs10133662; rs7492600; rs3783638; rs3783642; rs10131232; rs8017210; rs998259; rs9671371; rs10149945; rs8009759; rs12589758; rs7147286; rs8018688; rs7147201; rs10139282; rs7147200; rs17128021; rs7156475; rs10133661; rs11848732; rs7161034; rs12587434; rs10143089; rs4462519; rs10141456; rs17128052; rs10136545; rs11626298; rs7155501; rs10498472; rs3783641; rs17128050; rs752688; rs3783637; rs12147422; rs17128028; rs10133650; rs2183082; rs10873086; rs2183084; rs10129528; rs10133941; rs17128033; rs8019824; rs17253591; rs7141433; rs9671850; rs8018355; rs12432756; rs11158027; rs8010461; rs2878169; rs10131633; rs8020798; rs10150825; rs3783640; rs3783639; rs10498471; rs10220514; rs8009470; rs10149080; rs2149482; rs11626155; rs4363780; rs10134429; rs7141319; rs11620796; rs7155099; rs17253577; rs11850691; rs12879111; rs10220342; rs7140523; rs10140721; rs7155309; rs2149483; rs1952437; rs17128057; rs11158026; rs8010282; rs10147430; rs4402455; rs10782425; rs7141483; rs8011751; rs10134163; rs10138301; rs4363781; rs10132356; rs10146658; rs11627828; rs10137504; rs10145097; rs17832263; rs10144581; rs3825611; rs12885400; rs10138429; rs17253584; rs11627767; rs10220344; rs8019791; rs10137881; rs11626210; rs10139369; rs9989242; rs2183080; rs7493025; rs9671455; rs7142517; rs17739146; rs10137071; rs3759662; rs10144972; rs11851287; rs17671485; rs10144725; rs17128008; rs3759663; rs17128011; rs11847085; rs10136972; rs41298440; rs41298432; rs41298442; rs987; rs10151500; rs1753589; rs34156666; rs28458175; rs41298438; rs34808879; rs9743836; rs10444720; rs8011712; rs34787772; rs4047209; rs8016730; rs35533684; rs35111582; rs34499089; rs13329058; rs1136927; rs11461307; rs34544088; rs35662681; rs7147040; rs11439363; rs35987298; rs10131563; rs34339930; rs10138594; rs28757745; rs12884925; rs35139021; rs35880039; rs3965763; rs34713671; rs41298436; rs11444305; rs7153566; rs35776259; rs35265487; rs28481447; rs35926285; rs10598935; rs2878170; rs34618298; rs41298426; rs10146709; rs28532361; rs10645822; rs11312854; rs10133449; rs10143025; rs34119917; rs12883072; rs7153186; rs11845055; rs2878171; rs28477407; rs36225285; rs34831360; rs35041629; rs35951874; rs3825610; rs34027548; rs34037186; rs10129468; rs35476604; rs35827455; rs34859174; rs35407542; rs34576183; rs36095464; rs8003903; rs9805909; rs35116635; rs12323905; rs3945570; rs9672037; rs28542181; rs11412107; rs28643468; rs11844799; rs34191865; rs11624963; rs13329045; rs41298430; rs28413055; rs35587902; rs36150047; rs35600814; rs9972204; rs8010689; rs35892399; rs34163543; rs2183083; rs34635384; rs2004633; rs11410453; rs10545051; rs28417208; rs41298434; rs41298428; rs3759660; rs34824784; rs11468814; rs35711887; rs3759661; rs7342548; rs11468813; rs10695628; rs10145336; rs10483639; rs11621165; rs11847771; rs1187894; rs17127998; rs17128004; rs17671345; rs17738966; rs2057368; rs2057369; rs2145945; rs2878172; rs3759664; rs3759665; rs7148831; rs8007267; rs8008858

# Metabolic_Enzyme_6_General_References:
1520321; 8695054; 1482676; 8666288; 7730309; 8068008; 9222755; 7874165; 7501255; 8957022; 8852666; 9120469; 9328244; 9667588; 9778264; 10987649; 10582612; 10208576; 10076897; 10825351; 11113234; 12391354

# Metabolic_Enzyme_6_References:
15303002; 15389992; 15390021; 15959854

# Metabolic_Enzyme_7_ID:
7434

# Metabolic_Enzyme_7_Name:
Caspase-3 precursor

# Metabolic_Enzyme_7_Synonyms:
CASP-3; Apopain; Cysteine protease CPP32; Yama protein; CPP-32; SREBP cleavage activity 1; SCA-1[Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]

# Metabolic_Enzyme_7_Gene_Name:
CASP3

# Metabolic_Enzyme_7_Protein_Sequence:
>Caspase3 precursor
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

# Metabolic_Enzyme_7_Number_of_Residues:
277

# Metabolic_Enzyme_7_Molecular_Weight:
31608

# Metabolic_Enzyme_7_Theoretical_pI:
6.51

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  cysteine-type endopeptidase activity
Function:  caspase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
Not Available

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00656:Peptidase_C14

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.4.22.56

# Metabolic_Enzyme_7_GenBank_ID_Protein:
561666

# Metabolic_Enzyme_7_SwissProt_ID:
CASP3_HUMAN (P42574)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
CASP3

# Metabolic_Enzyme_7_Geneatlas_id:
CASP3

# Metabolic_Enzyme_7_hgnc_id:
HGNC:1504

# Metabolic_Enzyme_7_PDB_ID:
1CP3

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_7_Gene_Sequence:
>834 bp
ATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATC
ATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGAT
TATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGA
ATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAAC
TTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATG
CGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGC
CATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACA
AACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATT
CAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGAT
GACATGGCGTGTCATAAAATACCAGTGGATGCCGACTTCTTGTATGCATACTCCACAGCA
CCTGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGT
GCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAAC
CGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAA
CAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
U13737

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_7_Locus:
4q34

# Metabolic_Enzyme_7_SNPs:
rs35578277; rs1049210; rs35566035; rs1049253; rs2720378; rs3087455; rs6948; rs4647640; rs4647610; rs4647617; rs4647642; rs4647634; rs4647611; rs4647620; rs1049216; rs4647641; rs4647618; rs4647609; rs4647694; rs8549; rs4647698; rs4647614; rs4647621; rs4647622; rs4647616; rs4647633; rs4647643; rs4647630; rs34184817; rs4647647; rs35422505; rs4647624; rs4647626; rs4647696; rs4647606; rs4647631; rs4647646; rs4647607; rs4647625; rs34022730; rs35439719; rs2720377; rs4647632; rs4647628; rs2310103; rs34309992; rs4647629; rs4647644; rs4647636; rs2019978; rs2705891; rs1830254; rs2720376; rs2696056; rs4241793; rs4647667; rs4647688; rs4647663; rs1405942; rs4647652; rs1405938; rs4647662; rs2705901; rs1405944; rs4647671; rs4647665; rs2696057; rs4647693; rs4647672; rs2705897; rs4647669; rs4647673; rs4647692; rs4647674; rs4647666; rs4647686; rs4647683; rs4647690; rs4647657; rs4987118; rs4647679; rs4647670; rs4987119; rs4647658; rs4647684; rs4647675; rs4647650; rs34319440; rs4647685; rs2696048; rs4647651; rs4647676; rs4647687; rs4647655; rs13128316; rs13435139; rs4647704; rs4647700; rs12646257; rs4647701; rs4647623; rs4647635; rs10028033; rs12641602; rs13101834; rs11380373; rs4647695; rs34119644; rs2705892; rs34858791; rs35063555; rs4647699; rs4647639; rs34095700; rs4647619; rs13102911; rs4647645; rs4647612; rs13101835; rs4647637; rs4647638; rs2705893; rs4647649; rs2696060; rs10028034; rs4647697; rs4647613; rs35978407; rs4647608; rs4647615; rs28418774; rs4647648; rs1802667; rs34568867; rs7442206; rs4647682; rs4647656; rs4647681; rs4647668; rs4647677; rs4647678; rs4647691; rs35261594; rs4647689; rs4647653; rs35966919; rs34740772; rs4647659; rs41314884; rs9997231; rs3215361; rs4647661; rs4647654; rs10014306; rs10660141; rs4647664; rs4647660; rs4647680; rs10034836; rs35094553; rs9715122; rs4647705; rs34083547; rs9715863; rs4647702; rs4647703; rs11930666; rs12108497; rs12507711; rs13108061; rs13435890; rs1405937; rs2696058; rs2696059; rs2705881; rs2705882; rs2705900; rs2720388; rs2720389; rs34605630; rs4647600; rs4647602; rs4647603; rs4647605; rs4861629; rs4862396; rs4862399; rs7673753; rs7674164; rs7687648; rs9685847

# Metabolic_Enzyme_7_General_References:
7983002; 7774019; 7596430; 8673606; 9045680; 10821855; 8755496; 8696339

# Metabolic_Enzyme_7_References:
15596235

# Metabolic_Enzyme_8_ID:
5975

# Metabolic_Enzyme_8_Name:
Glutamate decarboxylase 2

# Metabolic_Enzyme_8_Synonyms:
Glutamate decarboxylase 65 kDa isoform; GAD-65; 65 kDa glutamic acid decarboxylase

# Metabolic_Enzyme_8_Gene_Name:
GAD2

# Metabolic_Enzyme_8_Protein_Sequence:
>Glutamate decarboxylase 2
MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGG
SQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQ
YVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFN
QLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFS
PGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVI
LIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIW
MHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQ
MHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEY
LYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEY
GTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL

# Metabolic_Enzyme_8_Number_of_Residues:
585

# Metabolic_Enzyme_8_Molecular_Weight:
65412

# Metabolic_Enzyme_8_Theoretical_pI:
6.89

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Catalyzes the production of GABA

# Metabolic_Enzyme_8_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00410  beta-Alanine metabolism;
 map00430  Taurine and hypotaurine metabolism;
 map00650  Butanoate metabolism

# Metabolic_Enzyme_8_Reaction:
L-glutamate = 4-aminobutanoate + CO2

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00282:Pyridoxal_deC

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 4.1.1.15

# Metabolic_Enzyme_8_GenBank_ID_Protein:
182934

# Metabolic_Enzyme_8_SwissProt_ID:
DCE2_HUMAN (Q05329)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
GAD2

# Metabolic_Enzyme_8_Geneatlas_id:
GAD2

# Metabolic_Enzyme_8_hgnc_id:
HGNC:4093

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasm; cytosol. Cytoplasmic vesicle. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters

# Metabolic_Enzyme_8_Gene_Sequence:
>1758 bp
ATGGCATCTCCGGGCTCTGGCTTTTGGTCTTTCGGGTCGGAAGATGGCTCTGGGGATTCC
GAGAATCCCGGCACAGCGCGAGCCTGGTGCCAAGTGGCTCAGAAGTTCACGGGCGGCATC
GGAAACAAACTGTGCGCCCTGCTCTACGGAGACGCCGAGAAGCCGGCGGAGAGCGGCGGG
AGCCAACCCCCGCGGGCCGCCGCCCGGAAGGCCGCCTGCGCCTGCGACCAGAAGCCCTGC
AGCTGCTCCAAAGTGGATGTCAACTACGCGTTTCTCCATGCAACAGACCTGCTGCCGGCG
TGTGATGGAGAAAGGCCCACTTTGGCGTTTCTGCAAGATGTTATGAACATTTTACTTCAG
TATGTGGTGAAAAGTTTCGATAGATCAACCAAAGTGATTGATTTCCATTATCCTAATGAG
CTTCTCCAAGAATATAATTGGGAATTGGCAGACCAACCACAAAATTTGGAGGAAATTTTG
ATGCATTGCCAAACAACTCTAAAATATGCAATTAAAACAGGGCATCCTAGATACTTCAAT
CAACTTTCTACTGGTTTGGATATGGTTGGATTAGCAGCAGACTGGCTGACATCAACAGCA
AATACTAACATGTTCACCTATGAAATTGCTCCAGTATTTGTGCTTTTGGAATATGTCACA
CTAAAGAAAATGAGAGAAATCATTGGCTGGCCAGGGGGCTCTGGCGATGGGATATTTTCT
CCCGGTGGCGCCATATCTAACATGTATGCCATGATGATCGCACGCTTTAAGATGTTCCCA
GAAGTCAAGGAGAAAGGAATGGCTGCTCTTCCCAGGCTCATTGCCTTCACGTCTGAACAT
AGTCATTTTTCTCTCAAGAAGGGAGCTGCAGCCTTAGGGATTGGAACAGACAGCGTGATT
CTGATTAAATGTGATGAGAGAGGGAAAATGATTCCATCTGATCTTGAAAGAAGGATTCTT
GAAGCCAAACAGAAAGGGTTTGTTCCTTTCCTCGTGAGTGCCACAGCTGGAACCACCGTG
TACGGAGCATTTGACCCCCTCTTAGCTGTCGCTGACATTTGCAAAAAGTATAAGATCTGG
ATGCATGTGGATGCAGCTTGGGGTGGGGGATTACTGATGTCCCGAAAACACAAGTGGAAA
CTGAGTGGCGTGGAGAGGGCCAACTCTGTGACGTGGAATCCACACAAGATGATGGGAGTC
CCTTTGCAGTGCTCTGCTCTCCTGGTTAGAGAAGAGGGATTGATGCAGAATTGCAACCAA
ATGCATGCCTCCTACCTCTTTCAGCAAGATAAACATTATGACCTGTCCTATGACACTGGA
GACAAGGCCTTACAGTGCGGACGCCACGTTGATGTTTTTAAACTATGGCTGATGTGGAGG
GCAAAGGGGACTACCGGGTTTGAAGCGCATGTTGATAAATGTTTGGAGTTGGCAGAGTAT
TTATACAACATCATAAAAAACCGAGAAGGATATGAGATGGTGTTTGATGGGAAGCCTCAG
CACACAAATGTCTGCTTCTGGTACATTCCTCCAAGCTTGCGTACTCTGGAAGACAATGAA
GAGAGAATGAGTCGCCTCTCGAAGGTGGCTCCAGTGATTAAAGCCAGAATGATGGAGTAT
GGAACCACAATGGTCAGCTACCAACCCTTGGGAGACAAGGTCAATTTCTTCCGCATGGTC
ATCTCAAACCCAGCGGCAACTCACCAAGACATTGACTTCCTGATTGAAGAAATAGAACGC
CTTGGACAAGATTTATAA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
M81882

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_8_Locus:
10p11.23

# Metabolic_Enzyme_8_SNPs:
rs2839672; rs2839678; rs1805397; rs2229845; rs7919405; rs1556234; rs3781106; rs8190809; rs1335547; rs3781105; rs3781107; rs8190811; rs8190812; rs8190817; rs8190816; rs8190800; rs8190590; rs8190813; rs8190805; rs8190801; rs7073217; rs8190802; rs8190814; rs8190807; rs8190815; rs8190803; rs992990; rs2368160; rs2368159; rs913963; rs913964; rs1999241; rs870341; rs928197; rs8190604; rs7906725; rs3781109; rs6482551; rs1330581; rs8190764; rs4749108; rs6482541; rs7897510; rs8190780; rs7071922; rs3893052; rs6482537; rs7073119; rs7900739; rs2839671; rs3781108; rs11015008; rs12267286; rs4994426; rs7893400; rs1330582; rs8190754; rs7087663; rs7900976; rs12414701; rs7074534; rs4144102; rs7074235; rs7068224; rs3847380; rs3781113; rs7902107; rs7076544; rs6482540; rs7913676; rs7908975; rs6482550; rs3781117; rs4747548; rs8190748; rs4749105; rs8190706; rs8190704; rs7087011; rs3781114; rs4749101; rs3847378; rs7893194; rs4747550; rs7913524; rs4749102; rs8190798; rs4749107; rs7095327; rs4747547; rs4747549; rs3847379; rs6482538; rs8190598; rs3824694; rs17667367; rs8190658; rs3781111; rs7081084; rs11015015; rs8190694; rs7897355; rs8190734; rs3904297; rs10828963; rs928198; rs913962; rs11015025; rs8190624; rs7099569; rs7918935; rs7072964; rs8190628; rs11015024; rs8190714; rs4749103; rs8190690; rs8190635; rs3781112; rs2839676; rs7909909; rs8190720; rs8190645; rs16926761; rs8190770; rs11594057; rs870342; rs6482544; rs7898281; rs1935996; rs8190708; rs8190716; rs3904298; rs8190597; rs8190779; rs3781116; rs12253114; rs8190660; rs7089304; rs3893253; rs7074934; rs2839675; rs8190796; rs4749104; rs12098763; rs7080514; rs8190685; rs7067571; rs6482543; rs7068510; rs8190611; rs12242971; rs1805398; rs7072137; rs8190689; rs8190646; rs11015010; rs11015028; rs8190718; rs2298124; rs2839674; rs8190713; rs7100268; rs6482548; rs7903208; rs7078680; rs1805399; rs8190678; rs8190701; rs8190612; rs3781118; rs3904296; rs8190637; rs8190683; rs8190673; rs8190782; rs7079102; rs6482542; rs11015004; rs12258601; rs12263667; rs7909902; rs8190620; rs8190650; rs7911425; rs6482547; rs913965; rs8190794; rs8190741; rs8190621; rs7895479; rs1330579; rs8190786; rs8190665; rs8190594; rs8190778; rs8190656; rs16926784; rs8190618; rs8190675; rs8190711; rs8190739; rs7091779; rs8190616; rs8190648; rs8190763; rs8190661; rs11015012; rs8190773; rs12248404; rs8190641; rs8190746; rs8190757; rs8190668; rs12358823; rs8190776; rs8190750; rs8190697; rs11015016; rs7067786; rs8190695; rs8190623; rs12258107; rs6482539; rs8190723; rs8190797; rs8190738; rs8190765; rs8190787; rs7915657; rs7912687; rs12251044; rs10828964; rs8190608; rs8190667; rs8190596; rs16926747; rs8190781; rs8190642; rs8190639; rs8190751; rs8190784; rs8190627; rs3781110; rs8190696; rs8190703; rs12254792; rs8190593; rs8190715; rs8190737; rs8190634; rs8190727; rs10160178; rs12098764; rs8190771; rs8190736; rs8190682; rs2839677; rs8190651; rs8190785; rs11015018; rs4111544; rs7911393; rs10466096; rs7080693; rs11015003; rs8190709; rs7909127; rs7922748; rs8190733; rs11015017; rs8190602; rs8190672; rs8190789; rs3904299; rs8190692; rs8190626; rs8190632; rs8190774; rs11015002; rs12243085; rs8190768; rs8190722; rs8190617; rs7905275; rs8190752; rs8190595; rs8190728; rs1330580; rs7893528; rs11015011; rs12360108; rs8190607; rs8190772; rs8190766; rs8190693; rs8190647; rs7089218; rs6482549; rs10466098; rs8190756; rs8190775; rs8190744; rs7914135; rs12243037; rs12240863; rs8190758; rs8190670; rs7076905; rs12269473; rs8190721; rs8190606; rs8190615; rs8190649; rs2236418; rs3758446; rs4749111; rs8190582; rs2839669; rs2839670; rs4747553; rs4749110; rs7090727; rs4747551; rs7090581; rs4747552; rs2236417; rs8190586; rs1065239; rs8190588; rs8190825; rs8190585; rs8190587; rs8190584; rs8190823; rs2839673; rs8190730; rs8190671; rs8190600; rs8190591; rs8190729; rs8190799; rs8190804; rs34587935; rs41279918; rs8190818; rs1360845; rs8190821; rs17847106; rs8190806; rs8190819; rs8190820; rs8190810; rs8190808; rs2210118; rs35598312; rs35399576; rs8190609; rs8190724; rs11015005; rs11015026; rs8190753; rs8190747; rs11812646; rs11015007; rs8190731; rs16926771; rs34544929; rs8190783; rs8190680; rs8190742; rs7914958; rs11424034; rs34446027; rs10706901; rs8190687; rs8190795; rs8190792; rs12242900; rs7912720; rs12765251; rs8190638; rs17847108; rs35729928; rs35302027; rs8190674; rs28411087; rs36068216; rs11015021; rs12413327; rs41279916; rs8190760; rs3831349; rs35525470; rs8190702; rs12240533; rs8190759; rs7077030; rs35027140; rs8190657; rs8190743; rs35001308; rs35095406; rs8190664; rs35193512; rs8190676; rs7898671; rs34460749; rs7910714; rs8190610; rs8190601; rs11015029; rs34165540; rs10571094; rs34714031; rs17847113; rs8190655; rs10466097; rs8190691; rs34544347; rs8190788; rs34492981; rs11397236; rs8190640; rs8190767; rs34551923; rs11015013; rs12240390; rs17847119; rs958295; rs7896603; rs8190613; rs11351928; rs8190793; rs35560251; rs8190777; rs12258225; rs4749109; rs35466733; rs8190619; rs12764007; rs8190677; rs8190712; rs8190684; rs8190652; rs8190761; rs11015023; rs8190717; rs3925895; rs12780466; rs35967087; rs10691988; rs41279914; rs8190654; rs35473617; rs7906622; rs8190622; rs8190699; rs8190700; rs35554915; rs8190790; rs8190614; rs34282513; rs7904959; rs35460917; rs35692804; rs35701656; rs5783968; rs41304597; rs8190740; rs11015030; rs7910604; rs12258527; rs4749100; rs8190755; rs12265834; rs7906659; rs7911822; rs8190681; rs11382565; rs10550716; rs8190726; rs41304609; rs7900313; rs12258214; rs8190599; rs11015014; rs8190633; rs8190605; rs11594128; rs7084058; rs8190643; rs35046451; rs7897227; rs35449881; rs11015009; rs35322930; rs35856372; rs35871778; rs11389512; rs8190636; rs11437464; rs8190653; rs35327186; rs35218393; rs8190745; rs34436183; rs11015006; rs35900771; rs8190732; rs8190735; rs12252062; rs7074897; rs8190791; rs8190725; rs8190666; rs8190669; rs8190631; rs8190707; rs8190679; rs8190749; rs34964656; rs34166651; rs35778757; rs8190719; rs8190710; rs8190686; rs35829665; rs11407523; rs8190625; rs11417128; rs8190659; rs36008357; rs16926745; rs8190698; rs8190769; rs11014999; rs8190603; rs8190705; rs7078821; rs11015027; rs8190762; rs8190644; rs4589175; rs8190589; rs8190822; rs8190583; rs34861013; rs10508715; rs11014998; rs11015031; rs11015032; rs11591556; rs12248143; rs12256696; rs12264198; rs12265385; rs1330574; rs16926835; rs16926836; rs1888251; rs2150157; rs2150158; rs2150159; rs2150160; rs2839668; rs7899642; rs7915415; rs7922791; rs8190828; rs8190830; rs876845; rs876846; rs876847; rs876848; rs882138; rs994502

# Metabolic_Enzyme_8_General_References:
1924293; 1549570; 8088791; 7680313; 8243826; 8999827; 12356867

# Metabolic_Enzyme_8_References:
15893579; 16325000

# Macromolecular_Interacting_Partner_1_ID:
7547

# Macromolecular_Interacting_Partner_1_Name:
Somatotropin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Growth hormone; GH; GH-N; Pituitary growth hormone; Growth hormone 1

# Macromolecular_Interacting_Partner_1_Gene_Name:
GH1

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Somatotropin precursor
MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEA
YIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLR
SVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDD
ALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
217

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
24848

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.09

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_1_Signals:
1-26

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
31905

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
SOMA_HUMAN (P01241)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
GH1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
GH1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:4261

# Macromolecular_Interacting_Partner_1_PDB_ID:
1HWG

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>654 bp
ATGGCTACAGGCTCCCGGACGTCCCTGCTCCTGGCTTTTGGCCTGCTCTGCCTGCCCTGG
CTTCAAGAGGGCAGTGCCTTCCCAACCATTCCCTTATCCAGGCCTTTTGACAACGCTATG
CTCCGCGCCCATCGTCTGCACCAGCTGGCCTTTGACACCTACCAGGAGTTTGAAGAAGCC
TATATCCCAAAGGAACAGAAGTATTCATTCCTGCAGAACCCCCAGACCTCCCTCTGTTTC
TCAGAGTCTATTCCGACACCCTCCAACAGGGAGGAAACACAACAGAAATCCAACCTAGAG
CTGCTCCGCATCTCCCTGCTGCTCATCCAGTCGTGGCTGGAGCCCGTGCAGTTCCTCAGG
AGTGTCTTCGCCAACAGCCTGGTGTACGGCGCCTCTGACAGCAACGTCTATGACCTCCTA
AAGGACCTAGAGGAAGGCATCCAAACGCTGATGGGGAGGCTGGAAGATGGCAGCCCCCGG
ACTGGGCAGATCTTCAAGCAGACCTACAGCAAGTTCGACACAAACTCACACAACGATGAC
GCACTACTCAAGAACTACGGGCTGCTCTACTGCTTCAGGAAGGACATGGACAAGGTCGAG
ACATTCCTGCGCATCGTGCAGTGCCGCTCTGTGGAGGGCAGCTGTGGCTTCTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00519

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_1_Locus:
17q24.2

# Macromolecular_Interacting_Partner_1_SNPs:
rs2001345; rs5388; rs6175; rs6173; rs6172; rs2665802; rs3744287; rs2001344; rs3020619; rs2005172; rs695; rs2854224; rs2854184; rs11568828; rs2011732; rs1974435; rs1811081; rs6171; rs2005171; rs2005170; rs7219235; rs2727338; rs6174; rs4080075; rs4080076; rs41295255; rs41295253; rs4080078; rs41295041; rs41295043; rs9282699; rs41295039; rs41295033; rs5821407; rs5821408; rs41295029; rs3833113; rs41295249; rs41295245; rs5821409; rs9282698; rs41295251; rs41295035; rs41295037; rs41295031; rs41295247; rs4341800; rs41299067; rs6146116; rs28485730; rs41295013; rs11568827; rs41295009; rs41295017; rs3760240; rs12945660; rs41295015; rs41299065; rs11079515; rs11657170; rs12946669; rs2070680; rs2532114; rs2532115; rs2665846; rs3180510; rs7209608

# Macromolecular_Interacting_Partner_1_General_References:
386281; 377496; 6269091; 7169009; 2744760; 10931946; 3912261; 5810834; 5144027; 4675454; 5279046; 5279528; 7462247; 7356479; 7028740; 10393484; 3447173; 1549776; 7984244; 8943276; 8552145; 9276733; 10391209; 11502836; 12655557

# Macromolecular_Interacting_Partner_1_References:
16934332

# Macromolecular_Interacting_Partner_2_ID:
7549

# Macromolecular_Interacting_Partner_2_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
INS

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_2_Signals:
1-24

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
INS

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_2_Locus:
11p15.5

# Macromolecular_Interacting_Partner_2_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_2_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_2_References:
15258132; 16339749

# Macromolecular_Interacting_Partner_3_ID:
6969

# Macromolecular_Interacting_Partner_3_Name:
Glutamate [NMDA] receptor subunit epsilon-2 precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
N-methyl D- aspartate receptor subtype 2B; NR2B; NMDAR2B; N-methyl-D-aspartate receptor subunit 3; NR3; hNR3

# Macromolecular_Interacting_Partner_3_Gene_Name:
GRIN2B

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Glutamate NMDA receptor subunit epsilon2 precursor
MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFH
HLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTL
TPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQ
DFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYI
FEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAII
TTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHP
KLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE
SVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYL
VTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSR
SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSF
TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYV
DQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLS
LKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAI
LQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH
LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILR
LLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFS
DYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISK
KPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKR
RKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTK
ENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVVSGVPAPWEKN
LTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSL
QELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPR
SVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPD
RVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPA
RFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
1484

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
166369

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  transporter activity
Function:  ion transporter activity
Function:  ion channel activity
Function:  ligand-gated ion channel activity
Function:  extracellular ligand-gated ion channel activity
Function:  excitatory extracellular ligand-gated ion channel activity
Function:  glutamate-gated ion channel activity
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  glutamate receptor activity
Function:  ionotropic glutamate receptor activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00060:Lig_chan

# Macromolecular_Interacting_Partner_3_Signals:
1-26

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
558-578
635-655
818-838

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
1899202

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
NMDE2_HUMAN (Q13224)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
GRIN2B

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
GRIN2B

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:4586

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>4455 bp
ATGAAGCCCAGAGCGGAGTGCTGTTCTCCCAAGTTCTGGTTGGTGTTGGCCGTCCTGGCC
GTGTCAGGCAGCAGAGCTCGTTCTCAGAAGAGCCCCCCCAGCATTGGCATTGCTGTCATC
CTCGTGGGCACTTCCGACGAGGTGGCCATCAAGGATGCCCACGAGAAAGATGATTTCCAC
CATCTCTCCGTGGTACCCCGGGTGGAACTGGTAGCCATGAATGAGACCGACCCAAAGAGC
ATCATCACCCGCATCTGTGATCTCATGTCTGACCGGAAGATCCAGGGGGTGGTGTTTGCT
GATGACACAGACCAGGAAGCCATCGCCCAGATCCTCGATTTCATTTCAGCACAGACTCTC
ACCCCGATCCTGGGCATCCACGGGGGCTCCTCTATGATAATGGCAGATAAGGATGAATCC
TCCATGTTCTTCCAGTTTGGCCCATCAATTGAACAGCAAGCTTCCGTAATGCTCAACATC
ATGGAAGAATATGACTGGTACATCTTTTCTATCGTCACCACCTATTTCCCTGGCTACCAG
GACTTTGTAAACAAGATCCGCAGCACCATTGAGAATAGCTTTGTGGGCTGGGAGCTAGAG
GAGGTCCTCCTACTGGACATGTCCCTGGACGATGGAGATTCTAAGATCCAGAATCAGCTC
AAGAAACTTCAAAGCCCCATCATTCTTCTTTACTGTACCAAGGAAGAAGCCACCTACATC
TTTGAAGTGGCCAACTCAGTAGGGCTGACTGGCTATGGCTACACGTGGATCGTGCCCAGT
CTGGTGGCAGGGGATACAGACACAGTGCCTGCGGAGTTCCCCACTGGGCTCATCTCTGTA
TCATATGATGAATGGGACTATGGCCTCCCCGCCAGAGTGAGAGATGGAATTGCCATAATC
ACCACTGCTGCTTCTGACATGCTGTCTGAGCACAGCTTCATCCCTGAGCCCAAAAGCAGT
TGTTACAACACCCACGAGAAGAGAATCTACCAGTCCAATATGCTAAATAGGTATCTGATC
AATGTCACTTTTGAGGGGAGGAATTTGTCCTTCAGTGAAGATGGCTACCAGATGCACCCG
AAACTGGTGATAATTCTTCTGAACAAGGAGAGGAAGTGGGAAAGGGTGGGGAAGTGGAAA
GACAAGTCCCTGCAGATGAAGTACTATGTGTGGCCCCGAATGTGTCCAGAGACTGAAGAG
CAGGAGGATGACCATCTGAGCATTGTGACCCTGGAGGAGGCACCATTTGTCATTGTGGAA
AGTGTGGACCCTCTGAGTGGAACCTGCATGAGGAACACAGTCCCCTGCCAAAAACGCATA
GTCACTGAGAATAAAACAGACGAGGAGCCGGGTTACATCAAAAAATGCTGCAAGGGGTTC
TGTATTGACATCCTTAAGAAAATTTCTAAATCTGTGAAGTTCACCTATGACCTTTACCTG
GTTACCAATGGCAAGCATGGGAAGAAAATCAATGGAACCTGGAATGGTATGATTGGAGAG
GTGGTCATGAAGAGGGCCTACATGGCAGTGGGCTCACTCACCATCAATGAGGAACGATCG
GAGGTGGTCGACTTCTCTGTGCCCTTCATAGAGACAGGCATCAGTGTCATGGTGTCACGC
AGCAATGGGACTGTCTCACCTTCTGCCTTCTTAGAGCCATTCAGCGCTGACGTATGGGTG
ATGATGTTTGTGATGCTGCTCATCGTCTCAGCCGTGGCTGTCTTTGTCTTTGAGTACTTC
AGCCCTGTGGGTTATAACAGGTGCCTCGCTGATGGCAGAGAGCCTGGTGGACCCTCTTTC
ACCATCGGCAAAGCTATTTGGTTGCTCTGGGGTCTGGTGTTTAACAACTCCGTACCTGTG
CAGAACCCAAAGGGGACCACCTCCAAGATCATGGTGTCAGTGTGGGCCTTCTTTGCTGTC
ATCTTCCTGGCCAGCTACACTGCCAACTTAGCTGCCTTCATGATCCAAGAGGAATATGTG
GACCAGGTTTCTGGCCTGAGCGACAAAAAGTTCCAGAGACCTAATGACTTCTCACCCCCT
TTCCGCTTTGGGACCGTGCCCAACGGCAGCACAGAGAGAAATATTCGCAATAACTATGCA
GAAATGCATGCCTACATGGGAAAGTTCAACCAGAGGGGTGTAGATGATGCATTGCTCTCC
CTGAAAACAGGGAAACTGGATGCCTTCATCTATGATGCAGCAGTGCTGAACTATATGGCA
GGCAGAGATGAAGGCTGCAAGCTGGTGACCATTGGCAGTGGGAAGGTCTTTGCTTCCACT
GGCTATGGCATTGCCATCCAAAAAGATTCTGGGTGGAAGCGCCAGGTGGACCTTGCTATC
CTGCAGCTCTTTGGAGATGGGGAGATGGAAGAACTGGAAGCTCTCTGGCTCACTGGCATT
TGTCACAATGAGAAGAATGAGGTCATGAGCAGCCAGCTGGACATTGACAACATGGCAGGG
GTCTTCTACATGTTGGGGGCGGCCATGGCTCTCAGCCTCATCACCTTCATCTGCGAACAC
CTTTTCTATTGGCAGTTCCGACATTGCTTTATGGGTGTCTGTTCTGGCAAGCCTGGCATG
GTCTTCTCCATCAGCAGAGGTATCTACAGCTGCATCCATGGGGTGGCGATCGAGGAGCGC
CAGTCTGTAATGAACTCCCCCACCGCAACCATGAACAACACACACTCCAACATCCTGCGC
CTGCTGCGCACGGCCAAGAACATGGCTAACCTGTCTGGTGTGAATGGCTCACCGCAGAGC
GCCCTGGACTTCATCCGACGGGAGTCATCCGTCTATGACATCTCAGAGCACCGCCGCAGC
TTCACGCATTCTGACTGCAAATCCTACAACAACCCGCCCTGTGAGGAGAACCTCTTCAGT
GACTACATCAGTGAGGTAGAGAGAACGTTCGGGAACCTGCAGCTGAAGGACAGCAACGTG
TACCAAGATCACTACCACCATCACCACCGGCCCCATAGTATTGGCAGTGCCAGCTCCATC
GATGGGCTCTACGACTGTGACAACCCACCCTTCACCACCCAGTCCAGGTCCATCAGCAAG
AAGCCCCTGGACATCGGCCTCCCCTCCTCCAAGCACAGCCAGCTCAGTGACCTGTACGGC
AAATTCTCCTTCAAGAGCGACCGCTACAGTGGCCACGACGACTTGATCCGCTCCGATGTC
TCTGACATCTCAACCCACACCGTCACCTATGGGAACATCGAGGGCAATGCCGCCAAGAGG
CGTAAGCAGCAATATAAGGACAGCCTGAAGAAGCGGCCTGCCTCGGCCAAGTCCCGCAGG
GAGTTTGACGAGATCGAGCTGGCCTACCGTCGCCGACCGCCCCGCTCCCCTGACCACAAG
CGCTACTTCAGGGACAAGGAAGGGCTACGGGACTTCTACCTGGACCAGTTCCGAACAAAG
GAGAACTCACCCCACTGGGAGCACGTAGACCTGACCGACATCTACAAGGAGCGGAGTGAT
GACTTTAAGCGCGACTCCATCAGCGGAGGAGGGCCCTGTACCAACAGGTCTCACATCAAG
CACGGGACGGGCGACAAACACGGCGTGGTCAGCGGGGTACCTGCACCTTGGGAGAAGAAC
CTGACCAACGTGGAGTGGGAGGACCGGTCCGGGGGCAACTTCTGCCGCAGCTGTCCCTCC
AAGCTGCACAACTACTCCACGACGGTGACGGGTCAGAACTCGGGCAGGCAGGCGTGCATC
CGGTGTGAGGCTTGCAAGAAAGCAGGCAACCTGTATGACATCAGTGAGGACAACTCCCTG
CAGGAACTGGACCAGCCGGCTGCCCCAGTGGCGGTGACGTCAAACGCCTCCACCACTAAG
TACCCTCAGAGCCCGACTAATTCCAAGGCCCAGAAGAAGAACCGGAACAAACTGCGCCGG
CAGCACTCCTACGACACCTTCGTGGACCTGCAGAAGGAAGAAGCCGCCCTGGCCCCGCGC
AGCGTAAGCCTGAAAGACAAGGGCCGATTCATGGATGGGAGCCCCTACGCCCACATGTTT
GAGATGTCAGCTGGCGAGAGCACCTTTGCCAACAACAAGTCCTCAGTGCCCACTGCCGGA
CATCACCACCACAACAACCCCGGCGGCGGGTACATGCTCAGCAAGTCGCTCTACCCTGAC
CGGGTCACGCAAAACCCTTTCATCCCCACTTTTGGGGACGACCAGTGCTTGCTCCATGGC
AGCAAATCCTACTTCTTCAGGCAGCCCACGGTGGCGGGGGCGTCGAAAGCCAGGCCGGAC
TTCCGGGCCCTTGTCACCAACAAGCCGGTGGTCTCGGCCCTTCATGGGGCCGTGCCAGCC
CGTTTCCAGAAGGACATCTGTATAGGGAACCAGTCCAACCCCTGTGTGCCTAACAACAAA
AACCCCAGGGCTTTCAATGGCTCCAGCAATGGGCATGTTTATGAGAAACTTTCTAGTATT
GAGTCTGATGTCTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
U90278

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_3_Locus:
12p12

# Macromolecular_Interacting_Partner_3_SNPs:
rs1806191; rs7301328; rs1805482; rs3026160; rs1805247; rs1805522; rs1805246; rs1806201; rs36031537; rs1124894; rs35025065; rs219905; rs2041986; rs219934; rs1981782; rs219912; rs1981781; rs219904; rs172677; rs1805476; rs219873; rs1421104; rs10845859; rs10845852; rs219927; rs219910; rs10492141; rs219891; rs219888; rs7297101; rs124626; rs219881; rs12319804; rs1206437; rs10772719; rs10845862; rs1119262; rs10845848; rs7311519; rs10845861; rs890; rs4432098; rs4764038; rs4764041; rs219931; rs219878; rs7952915; rs219885; rs219915; rs1421110; rs888300; rs1558906; rs10845858; rs10845853; rs10772715; rs219876; rs219921; rs7311110; rs6488626; rs2160729; rs219887; rs1592669; rs956768; rs219902; rs4763361; rs1558908; rs2111511; rs219936; rs1805477; rs219879; rs6488623; rs10845863; rs2098469; rs10505778; rs717700; rs759619; rs219889; rs11055693; rs219933; rs219913; rs6488625; rs219877; rs7314376; rs1345485; rs219923; rs1558907; rs10845849; rs11055665; rs219900; rs219884; rs219922; rs4764039; rs918168; rs10772720; rs10845865; rs10772716; rs10845864; rs1805503; rs2160727; rs219935; rs7312680; rs11830268; rs12582848; rs10772717; rs11610517; rs219917; rs10845856; rs1805502; rs1421106; rs1421109; rs12829455; rs11055666; rs16909523; rs17834080; rs10845854; rs11055682; rs12299003; rs9645755; rs6488624; rs12818068; rs17339365; rs7298664; rs7134291; rs16909619; rs11055664; rs7295850; rs12426262; rs10845851; rs7962803; rs7134097; rs1421105; rs7315705; rs9971835; rs2160728; rs7962558; rs219914; rs219892; rs12368362; rs10772718; rs11055660; rs7303387; rs11055678; rs7311764; rs11055685; rs10160840; rs1362816; rs11055687; rs219872; rs12579598; rs219918; rs12821108; rs219907; rs17834128; rs11055692; rs219894; rs7309309; rs10845855; rs16909536; rs12302403; rs7970022; rs219920; rs219929; rs10845847; rs219909; rs11055699; rs4763360; rs2032713; rs10492142; rs11055673; rs10772714; rs10744042; rs219932; rs11055686; rs2216344; rs7972390; rs219886; rs10492140; rs219897; rs12828473; rs11055694; rs17221245; rs7962533; rs11055688; rs7962564; rs1421099; rs7962322; rs219924; rs12827844; rs12827536; rs11609547; rs219911; rs219906; rs9788202; rs219895; rs12820037; rs219880; rs7310209; rs11836232; rs7959821; rs7962314; rs10845846; rs9795898; rs11055654; rs17834134; rs7314105; rs1421107; rs219883; rs11055684; rs11055657; rs11055670; rs7304459; rs9971865; rs11055652; rs12322168; rs219930; rs4764043; rs10466774; rs219908; rs12581502; rs11055676; rs219893; rs11055680; rs219874; rs2058909; rs7969900; rs7960127; rs7308191; rs219899; rs11055671; rs11055674; rs7971933; rs9645754; rs11055659; rs11612709; rs12582621; rs10845857; rs219896; rs7295555; rs11055655; rs1421108; rs1805504; rs11055681; rs219882; rs10466773; rs16909528; rs12829989; rs11055675; rs10845860; rs12823982; rs7312179; rs16909526; rs7963561; rs17761383; rs766831; rs10845850; rs10459061; rs11055683; rs11055697; rs219903; rs36106803; rs1895055; rs16909621; rs7295364; rs12824372; rs11055663; rs12826869; rs7136375; rs12425273; rs765688; rs220558; rs2268120; rs1805485; rs2284404; rs1805483; rs220596; rs220594; rs1805481; rs2268107; rs220587; rs1805552; rs1806194; rs2284416; rs1805543; rs2193509; rs2300242; rs2160734; rs1805470; rs2284418; rs2216128; rs2160733; rs1012586; rs2300238; rs2192972; rs1805473; rs2192970; rs2300246; rs918065; rs2268102; rs220597; rs2192975; rs2268125; rs3026168; rs2284415; rs220549; rs2300265; rs1012587; rs2193150; rs2193147; rs2192977; rs1008619; rs759516; rs741328; rs2300267; rs765687; rs2300243; rs220553; rs2284425; rs2268100; rs2058878; rs741359; rs11055603; rs2268103; rs1861578; rs7297761; rs7974275; rs2193155; rs1806203; rs7970144; rs220564; rs4764014; rs2111514; rs7313149; rs10772703; rs1805472; rs2072539; rs2270359; rs10845824; rs741327; rs11055594; rs4764028; rs1805547; rs4554984; rs7309380; rs888150; rs2193512; rs1861786; rs4763353; rs2300272; rs11612353; rs1806198; rs1806195; rs7968071; rs10845822; rs2300257; rs2300249; rs220599; rs2284424; rs220592; rs6488611; rs10845839; rs2300270; rs2216217; rs11055584; rs1805527; rs10772698; rs10772710; rs10845820; rs2284407; rs1806218; rs1805545; rs220568; rs1805553; rs2300259; rs7311774; rs995802; rs12422385; rs2300234; rs7305892; rs2268127; rs220575; rs1806202; rs10772700; rs10845834; rs2216214; rs7972662; rs722646; rs11055608; rs11055577; rs2284411; rs2300279; rs11055586; rs4764011; rs2268110; rs6488621; rs2268113; rs4763357; rs1806209; rs918092; rs12301788; rs1075010; rs178325; rs2268119; rs11055616; rs10744039; rs11611101; rs7955894; rs3026182; rs2300273; rs4764036; rs6488612; rs2268121; rs7970177; rs7296762; rs10492129; rs1120905; rs1805513; rs4140765; rs2268117; rs10845843; rs220557; rs1805484; rs2110982; rs4763354; rs723095; rs2300261; rs1806196; rs10845838; rs10772694; rs10492132; rs2160402; rs2268104; rs7314871; rs2268123; rs2192979; rs3026167; rs11055619; rs7301754; rs1805539; rs10845826; rs11611183; rs7966866; rs2193511; rs2192973; rs10492138; rs2300245; rs2216130; rs10772701; rs2160732; rs2300244; rs4764034; rs995803; rs11611022; rs2268114; rs1805551; rs4764025; rs1125236; rs11612284; rs10845819; rs1005549; rs2268109; rs2300258; rs7958127; rs2193146; rs7958453; rs3026187; rs10492134; rs4764023; rs2216127; rs7316060; rs7316902; rs6488620; rs2300233; rs220563; rs11055587; rs2300271; rs1805490; rs2900314; rs7952874; rs7972742; rs1805474; rs220559; rs2417306; rs2111513; rs1072388; rs7967590; rs2284426; rs10845844; rs16909382; rs10772712; rs7956097; rs16909348; rs7297313; rs1805544; rs3794309; rs3903080; rs12809496; rs11055624; rs10845807; rs12305339; rs2268105; rs10772695; rs17220306; rs11615752; rs11613831; rs10772706; rs1160295; rs4378473; rs10492128; rs11055629; rs10845837; rs12312199; rs10492131; rs11838083; rs220586; rs1805558; rs16909305; rs7133408; rs7307315; rs220567; rs2268130; rs220572; rs1805491; rs11614721; rs4140764; rs12825107; rs2111512; rs1805546; rs4764026; rs4764019; rs12826365; rs11832003; rs2192976; rs17833967; rs12313659; rs10772693; rs1805549; rs10772705; rs723096; rs4764035; rs2300236; rs16909386; rs2284405; rs11055628; rs980365; rs1805488; rs11055606; rs2268135; rs7312845; rs17833759; rs2268108; rs17833908; rs12582333; rs16909222; rs4764021; rs3026186; rs220573; rs16909411; rs2300260; rs12300851; rs2268115; rs1158541; rs10492137; rs16909446; rs1806212; rs1806216; rs1861787; rs11055614; rs2300251; rs11055626; rs10744037; rs7979850; rs2284402; rs11609120; rs1805550; rs17760889; rs7301500; rs2268101; rs2193510; rs12310355; rs12321712; rs7138298; rs10845827; rs220581; rs11055528; rs2268092; rs10492139; rs1805526; rs10845841; rs10492133; rs4764031; rs11055556; rs12811098; rs220583; rs10772707; rs11055568; rs17833849; rs2268131; rs220578; rs10772692; rs1805559; rs2300252; rs1806192; rs11055612; rs11610518; rs10845814; rs2284410; rs7301820; rs2300241; rs10772713; rs11055581; rs7958180; rs2268095; rs11837589; rs1861788; rs1806204; rs7294947; rs10845831; rs11836523; rs10492136; rs731086; rs2300254; rs7970407; rs10772704; rs11832404; rs220593; rs2284408; rs1805554; rs10492130; rs1805471; rs2284409; rs10845845; rs11055597; rs12319253; rs11055613; rs2160730; rs4764027; rs2284423; rs2160519; rs11611667; rs17760842; rs2193513; rs11055621; rs11831620; rs17760662; rs2300268; rs11835020; rs2300263; rs2268126; rs7975387; rs2284406; rs7977601; rs1805478; rs11055649; rs1806217; rs10845840; rs11055625; rs1805479; rs1805510; rs2417303; rs11833339; rs4763355; rs1806193; rs52135; rs1861452; rs990824; rs2284412; rs1805519; rs2268096; rs220579; rs1805506; rs7964929; rs220590; rs3026164; rs1806199; rs17220663; rs220582; rs4763358; rs16909436; rs6488619; rs1806210; rs2300256; rs12313441; rs1806213; rs220560; rs2268118; rs11832541; rs10845809; rs7961779; rs7296938; rs1015829; rs2300253; rs2300250; rs2110984; rs220576; rs7296696; rs11608748; rs9988991; rs12303916; rs7976496; rs220595; rs12371702; rs10734871; rs1805480; rs11055651; rs741360; rs7309028; rs11830048; rs11610756; rs2193151; rs11055535; rs17760877; rs2268111; rs7296686; rs12422772; rs2268116; rs16909329; rs16909218; rs2268099; rs12578850; rs2300269; rs2268129; rs220570; rs2300278; rs11055541; rs1805536; rs11611572; rs7298328; rs12308271; rs2300255; rs2216213; rs1805525; rs2216129; rs17833902; rs7300283; rs11055636; rs2216219; rs11608687; rs2268124; rs17220537; rs17833896; rs764097; rs2284422; rs7977989; rs11608449; rs2012055; rs2268122; rs2300247; rs1805516; rs17761286; rs6488615; rs6488613; rs7977091; rs11613156; rs10845832; rs17760909; rs11494642; rs1805529; rs11612144; rs220566; rs1806205; rs1805199; rs12303001; rs1079846; rs220556; rs1805555; rs11055592; rs1805509; rs12321321; rs220598; rs11832499; rs220577; rs1806214; rs1806215; rs16909400; rs10845815; rs10772708; rs2417305; rs11055582; rs2284428; rs11610084; rs7962331; rs7956641; rs220580; rs7299327; rs1805523; rs7956244; rs11055531; rs2284413; rs7962493; rs1005047; rs7315660; rs12306580; rs2192978; rs12298994; rs11055591; rs1805508; rs1806207; rs4763356; rs12372461; rs2300235; rs7963715; rs12369725; rs1805560; rs11612494; rs3026175; rs2216216; rs11610953; rs1805532; rs7313957; rs1805548; rs11055530; rs2193148; rs11055643; rs11055526; rs7313323; rs2193153; rs11832226; rs11837351; rs11055646; rs12317299; rs12321547; rs7135991; rs1805520; rs7977831; rs7314092; rs2192974; rs12809820; rs16909476; rs10492135; rs7968084; rs220571; rs10845810; rs11055596; rs2110983; rs2268133; rs1558769; rs11055601; rs2008625; rs7299611; rs1805518; rs7975217; rs7963554; rs4623992; rs10772696; rs7964999; rs12227569; rs7961783; rs2284419; rs1805541; rs11055648; rs11055564; rs1805505; rs4764024; rs220584; rs4280084; rs1805530; rs7967652; rs7135730; rs7358660; rs11837924; rs7960371; rs220561; rs11055623; rs12579537; rs2300264; rs1805511; rs7315392; rs16909451; rs220565; rs1805556; rs1805524; rs7301995; rs17833674; rs16909362; rs10772702; rs17822337; rs3026185; rs11055595; rs11055547; rs10845825; rs7953807; rs1806197; rs7296874; rs2300239; rs2058771; rs2300266; rs2284421; rs11055620; rs2193152; rs17833585; rs1805540; rs1805486; rs11055558; rs17833932; rs2216211; rs11055642; rs11055548; rs10845808; rs10732565; rs220551; rs11608931; rs1805521; rs2270358; rs11608471; rs11055593; rs4764032; rs10845823; rs10845816; rs12308472; rs12580785; rs10772709; rs7315644; rs2268097; rs11834995; rs2284414; rs888151; rs11055631; rs12372476; rs220585; rs220588; rs11055553; rs1806206; rs7301425; rs11055560; rs12815392; rs11834511; rs10845836; rs1805515; rs141658; rs3026170; rs12303843; rs7956383; rs10845833; rs2284403; rs3026179; rs1805557; rs220589; rs7956854; rs7966070; rs10845811; rs7298633; rs11055555; rs12370138; rs11612636; rs7953995; rs11609779; rs2268093; rs2058772; rs17833639; rs220569; rs11837352; rs220562; rs11055615; rs17761280; rs1558768; rs12426790; rs1805489; rs17833861; rs2268134; rs11055557; rs2216218; rs3026159; rs12303812; rs2268136; rs17761053; rs7955546; rs1805531; rs1805561; rs220574; rs11836818; rs3026181; rs16909438; rs17833961; rs7954405; rs2058770; rs2041889; rs11608896; rs10845828; rs16909366; rs11055647; rs971165; rs17760854; rs11055549; rs759515; rs7299420; rs11055565; rs2268112; rs11615510; rs10845842; rs11609651; rs888149; rs17761184; rs12366758; rs1805537; rs1805512; rs2300237; rs12229800; rs2284420; rs17761268; rs11055559; rs11611570; rs4764012; rs1805517; rs4764020; rs1805487; rs17821180; rs11055630; rs11055607; rs1805542; rs2268132; rs2193508; rs2193156; rs2268128; rs11829616; rs2268098; rs3026173; rs12579289; rs4522263; rs1019385; rs1805501; rs3764030; rs7307302; rs1558767; rs3026174; rs1558766; rs1042339; rs34315573; rs3026183; rs1806200; rs3026177; rs35125534; rs35881592; rs34925746; rs2193506; rs10555482; rs4474538; rs11055668; rs7966018; rs5796566; rs4763359; rs35265263; rs11055656; rs3082919; rs35830700; rs1042340; rs10659703; rs35881014; rs11055661; rs12302739; rs7303885; rs7305496; rs12099959; rs34349334; rs11055691; rs34414824; rs36072596; rs35792580; rs35973211; rs4285967; rs11401635; rs11297910; rs7305583; rs35133933; rs7294424; rs36115133; rs28716869; rs11055658; rs219926; rs11055672; rs12313249; rs35922145; rs35028277; rs7979946; rs33931290; rs11354278; rs3082841; rs9634132; rs12578764; rs34364122; rs11323797; rs34692242; rs219919; rs11055700; rs11451380; rs10744041; rs34287194; rs34390230; rs11055679; rs5796571; rs2041987; rs35023592; rs12580205; rs7967372; rs34962020; rs11055689; rs35450101; rs34921743; rs7959810; rs12305387; rs2417307; rs12303284; rs34781288; rs35136343; rs11055662; rs28378725; rs34075291; rs34194926; rs5796568; rs36112750; rs219901; rs35395295; rs35456028; rs7131939; rs11055669; rs11297048; rs1042341; rs34833663; rs36018978; rs7969883; rs219925; rs34186912; rs7299951; rs35740551; rs732051; rs34223529; rs35373437; rs35625430; rs12830979; rs11610428; rs34635430; rs28695969; rs5796569; rs34993013; rs219898; rs34542872; rs10700426; rs219928; rs11055667; rs35153679; rs11055695; rs34569945; rs741447; rs11355806; rs7136790; rs11320973; rs35310294; rs7978741; rs34903162; rs35573365; rs34086755; rs5796567; rs28480194; rs10431310; rs35853794; rs35967221; rs10687616; rs34066708; rs35666762; rs6144621; rs5796570; rs34339624; rs35906313; rs35439566; rs35367670; rs11835228; rs35373717; rs35563539; rs4764040; rs4468438; rs12817922; rs34852374; rs34464239; rs11055690; rs36093554; rs34405899; rs12423997; rs12302798; rs34607033; rs34902286; rs12302324; rs3863343; rs11055653; rs7970422; rs34834455; rs11427852; rs35703691; rs12300348; rs35971469; rs34870448; rs4764042; rs219875; rs12228168; rs10659702; rs219916; rs35928475; rs34021489; rs11614993; rs34190327; rs34840030; rs7304013; rs34056061; rs12366316; rs34454922; rs34100660; rs34087989; rs36064040; rs34425195; rs34093837; rs34200530; rs11055550; rs11289295; rs1016319; rs12146728; rs1805534; rs34863972; rs2300240; rs35861557; rs34462939; rs11055580; rs11831087; rs41276682; rs1805514; rs7488581; rs7973529; rs34241142; rs12317264; rs12296286; rs2284398; rs34793364; rs35921524; rs34973181; rs35914883; rs918064; rs11055573; rs34064197; rs3082833; rs35924126; rs11612963; rs11055618; rs12228853; rs12301745; rs220552; rs11055563; rs12823393; rs12318041; rs3026184; rs11832243; rs12371450; rs28418784; rs12299830; rs33929265; rs7303029; rs11400953; rs1468818; rs34487084; rs7304601; rs11837079; rs4592502; rs35430618; rs1111202; rs10541414; rs34850566; rs7954724; rs34677997; rs34374408; rs35580358; rs11055561; rs34102889; rs2160731; rs5796559; rs34984059; rs4764016; rs12300150; rs34381901; rs4590971; rs12227636; rs1805507; rs35728300; rs35522519; rs11055605; rs11055533; rs2080395; rs11055641; rs35154495; rs12582266; rs11608386; rs11055600; rs10596988; rs35657830; rs7953493; rs11055622; rs4995193; rs12305933; rs36063085; rs10673813; rs34542626; rs3026169; rs7960143; rs9669763; rs12823775; rs12821566; rs35255758; rs7136868; rs12816165; rs11055579; rs34908554; rs12424933; rs12819919; rs25562; rs34417194; rs2417294; rs34048866; rs11409702; rs12366858; rs2268094; rs1073212; rs35655729; rs12819089; rs12313594; rs35890026; rs35774072; rs2268137; rs35163188; rs2284399; rs4491338; rs34310469; rs11055589; rs5796564; rs35363829; rs3026178; rs5796557; rs34508286; rs10219518; rs36049027; rs7135605; rs888148; rs7980772; rs34579703; rs34133370; rs11055566; rs34523345; rs36045898; rs10592592; rs12369642; rs220555; rs34520630; rs3026158; rs10555252; rs34777201; rs10626018; rs3081936; rs9668030; rs35767761; rs10772699; rs10699741; rs7973158; rs10845817; rs10623346; rs35701007; rs2300277; rs1861453; rs3863342; rs7137583; rs12302870; rs3831781; rs12371397; rs34192141; rs7977556; rs10734870; rs12823010; rs3751257; rs5796565; rs10580486; rs11055583; rs11322644; rs34866541; rs1468845; rs220591; rs33988773; rs5796556; rs12427329; rs3026165; rs2216345; rs11614390; rs34066937; rs12822618; rs5796555; rs35785955; rs35311759; rs3081918; rs35884224; rs11055610; rs11833955; rs35222999; rs4354776; rs34039800; rs34620639; rs35674397; rs3216541; rs11608451; rs12582803; rs35971137; rs12308194; rs34674026; rs34740128; rs11611454; rs2216131; rs12306487; rs2300274; rs34406907; rs4590972; rs991926; rs34318671; rs35713862; rs12822624; rs220554; rs36031751; rs34844004; rs2417292; rs12823211; rs35062527; rs33916459; rs10675760; rs11055638; rs5796563; rs10567199; rs2900315; rs34943652; rs35354725; rs3026162; rs5796561; rs35671395; rs34451205; rs11055574; rs34894103; rs35237281; rs12582653; rs11055598; rs35902063; rs34528054; rs971166; rs35914154; rs7962828; rs7488872; rs1805538; rs5796553; rs35592465; rs35861156; rs34773248; rs11055634; rs34596965; rs1806211; rs34664969; rs34991672; rs35831204; rs35694730; rs1805535; rs7952960; rs12299316; rs1972414; rs28651395; rs34148952; rs11609602; rs11055540; rs17760975; rs2417304; rs35295246; rs10702427; rs12823855; rs11055633; rs35891931; rs4583065; rs11055650; rs34768790; rs11055534; rs11461124; rs10577333; rs34300409; rs12311307; rs35874380; rs35798230; rs2300248; rs12319509; rs35883622; rs7300768; rs11832972; rs2284427; rs35906800; rs979428; rs12227473; rs12822825; rs2284401; rs9788024; rs35095483; rs35529431; rs7296965; rs34014224; rs12819411; rs35284330; rs11615972; rs35113935; rs11055611; rs34082754; rs10536664; rs4764029; rs11055590; rs36019540; rs35807653; rs220550; rs11055562; rs35469077; rs11323998; rs11610410; rs35745496; rs36013432; rs35371790; rs11055639; rs34818568; rs2193507; rs36108949; rs34850853; rs7967569; rs4764013; rs10744036; rs3026180; rs11055542; rs34714415; rs11055527; rs7316495; rs2417293; rs34266526; rs35080634; rs10539405; rs35305955; rs34791681; rs34800539; rs7975006; rs918093; rs35175755; rs35628486; rs7959906; rs7488866; rs1541590; rs12823041; rs7976206; rs17760567; rs34641444; rs35827820; rs35003662; rs7298760; rs34061912; rs34542349; rs2300275; rs34999431; rs11055627; rs34467334; rs1806208; rs34942586; rs3216540; rs3082838; rs1805533; rs35969486; rs3835374; rs12822817; rs11055536; rs2268106; rs5796558; rs33989850; rs4539420; rs35695461; rs35231516; rs12823004; rs34841708; rs33976982; rs12828878; rs34961138; rs34245298; rs35426433; rs34942148; rs11331475; rs35220928; rs4764018; rs34008234; rs2268138; rs28621435; rs11055604; rs12823221; rs35077822; rs11352671; rs1805244; rs9630251; rs2193154; rs34182908; rs35995671; rs35452504; rs34412036; rs34775187; rs11055645; rs11829584; rs10571641; rs28450731; rs11055529; rs12303170; rs7305308; rs4363702; rs10678628; rs3026166; rs3081920; rs12318431; rs34363660; rs11831422; rs7486647; rs12308068; rs35583863; rs34538391; rs2417295; rs1210658; rs12581278; rs35825957; rs7316067; rs12184498; rs12819090; rs11055537; rs2284417; rs7138270; rs35745328; rs12317483; rs888147; rs11055544; rs12581943; rs35379166; rs35254142; rs11055585; rs12369724; rs10548365; rs35958099; rs36010230; rs35551197; rs10772697; rs11055599; rs1805528; rs7310950; rs35902436; rs12227576; rs11387346; rs12308316; rs7316069; rs12317489; rs1303952; rs7305084; rs35547052; rs3831780; rs11055632; rs11055578; rs36058658; rs12366712; rs5796562; rs12315475; rs4764030; rs11055637; rs11055575; rs12427328; rs3026176; rs12580659; rs33948119; rs35927752; rs3026163; rs34320563; rs3216539; rs10581339; rs34795063; rs34522119; rs3833794; rs5796554; rs35281287; rs34181996; rs11055576; rs3216542; rs12825191; rs11055539; rs2160520; rs34737571; rs5796560; rs4764010; rs2077322; rs35687152; rs12316188; rs4140819; rs1024840; rs34289984; rs34332031; rs5796551; rs2284400; rs36095423; rs12303406; rs34941408; rs11055609; rs7303248; rs3082840; rs35688960; rs2300276; rs11055546; rs3751258; rs34025626; rs2216215; rs35859853; rs34557687; rs11829531; rs12318390; rs2284397; rs34823437; rs35351695; rs10615683; rs35546189; rs12300019; rs11055640; rs4995192; rs10400484; rs28464492; rs35185840; rs34445532; rs34499349; rs36020987; rs35279518; rs10400446; rs34179266; rs3834938; rs11615290; rs35260946; rs35464354; rs1024893; rs10400467; rs10734869; rs11832768; rs11835673; rs12307360; rs12368476; rs12423978; rs1805237; rs1805475; rs1805492; rs1805493; rs1805494; rs1805495; rs1805496; rs1805497; rs1805498; rs1895056; rs1895057; rs2160517; rs2160518; rs2193149; rs2216212; rs3026172; rs34510688; rs35485664; rs35715800; rs3764028; rs764525; rs7957488; rs7963188; rs7974547; rs966664

# Macromolecular_Interacting_Partner_3_General_References:
7999784; 8768735; 7959773; 9547169

# Macromolecular_Interacting_Partner_3_References:
15223297

# Macromolecular_Interacting_Partner_4_ID:
8005

# Macromolecular_Interacting_Partner_4_Name:
Proto-oncogene protein c-fos

# Macromolecular_Interacting_Partner_4_Synonyms:
Cellular oncogene fos; G0/G1 switch regulatory protein 7

# Macromolecular_Interacting_Partner_4_Gene_Name:
FOS

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Protooncogene protein cfos
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANF
IPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRA
QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ
TEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT
LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYA
ADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRK
GSSSNEPSSDSLSSPTLLAL

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
380

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
40696

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
4.50

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, c-fos and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF07716:bZIP_2

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
29904

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
FOS_HUMAN (P01100)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
FOS

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
FOS

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:3796

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1143 bp
ATGATGTTCTCGGGCTTCAACGCAGACTACGAGGCGTCATCCTCCCGCTGCAGCAGCGCG
TCCCCGGCCGGGGATAGCCTCTCTTACTACCACTCACCCGCAGACTCCTTCTCCAGCATG
GGCTCGCCTGTCAACGCGCAGGACTTCTGCACGGACCTGGCCGTCTCCAGTGCCAACTTC
ATTCCCACGGTCACTGCCATCTCGACCAGTCCGGACCTGCAGTGGCTGGTGCAGCCCGCC
CTCGTCTCCTCTGTGGCCCCATCGCAGACCAGAGCCCCTCACCCTTTCGGAGTCCCCGCC
CCCTCCGCTGGGGCTTACTCCAGGGCTGGCGTTGTGAAGACCATGACAGGAGGCCGAGCG
CAGAGCATTGGCAGGAGGGGCAAGGTGGAACAGTTATCTCCAGAAGAAGAAGAGAAAAGG
AGAATCCGAAGGGAAAGGAATAAGATGGCTGCAGCCAAATGCCGCAACCGGAGGAGGGAG
CTGACTGATACACTCCAAGCGGAGACAGACCAACTAGAAGATGAGAAGTCTGCTTTGCAG
ACCGAGATTGCCAACCTGCTGAAGGAGAAGGAAAAACTAGAGTTCATCCTGGCAGCTCAC
CGACCTGCCTGCAAGATCCCTGATGACCTGGGCTTCCCAGAAGAGATGTCTGTGGCTTCC
CTTGATCTGACTGGGGGCCTGCCAGAGGTTGCCACCCCGGAGTCTGAGGAGGCCTTCACC
CTGCCTCTCCTCAATGACCCTGAGCCCAAGCCCTCAGTGGAACCTGTCAAGAGCATCAGC
AGCATGGAGCTGAAGACCGAGCCCTTTGATGACTTCCTGTTCCCAGCATCATCCAGGCCC
AGTGGCTCTGAGACAGCCCGCTCCGTGCCAGACATGGACCTATCTGGGTCCTTCTATGCA
GCAGACTGGGAGCCTCTGCACAGTGGCTCCCTGGGGATGGGGCCCATGGCCACAGAGCTG
GAGCCCCTGTGCACTCCGGTGGTCACCTGTACTCCCAGCTGCACTGCTTACACGTCTTCC
TTCGTCTTCACCTACCCCGAGGCTGACTCCTTCCCCAGCTGTGCAGCTGCCCACCGCAAG
GGCAGCAGCAGCAATGAGCCTTCCTCTGACTCGCTCAGCTCACCCACGCTGCTGGCCCTG
TGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
V01512

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_4_Locus:
14q24.3

# Macromolecular_Interacting_Partner_4_SNPs:
rs2229024; rs1046117; rs4645857; rs7101; rs2239615; rs4645855; rs4645856; rs3216792; rs35706183; rs4645853; rs1063169; rs4645854; rs35586383; rs932257; rs2234706; rs4645850; rs4645859; rs4645852; rs4645849; rs1046283; rs3180688; rs4645858; rs14371; rs11354110; rs35423373; rs4645861; rs4645848; rs10142078; rs4645860; rs4645847; rs4645851; rs1005367; rs1009392; rs10133192; rs10133595; rs10144025; rs11159131; rs1569328; rs17103109; rs3742769; rs3742770; rs4645869; rs4645870; rs4645875; rs4645876; rs4645877; rs4903301; rs4903304; rs6574222; rs7146378; rs7154366; rs926113

# Macromolecular_Interacting_Partner_4_General_References:
6574479; 2516827; 12508121; 1658710; 2511004; 7816143

# Macromolecular_Interacting_Partner_4_References:
16386717; 16504219; 16706847

# Macromolecular_Interacting_Partner_5_ID:
8172

# Macromolecular_Interacting_Partner_5_Name:
Beta-neoendorphin-dynorphin precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
Proenkephalin B; Preprodynorphin[Contains: Beta-neoendorphin; Dynorphin; Leu- enkephalin; Rimorphin; Leumorphin]

# Macromolecular_Interacting_Partner_5_Gene_Name:
PDYN

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Betaneoendorphindynorphin precursor
MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWE
RCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKEN
TLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLR
KYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRS
QEDPNAYSGELFDA

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
254

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
28385

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.10

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
Process:  neuropeptide signaling pathway
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF01160:Opiods_neuropep

# Macromolecular_Interacting_Partner_5_Signals:
1-20

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
PDYN_HUMAN (P01213)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
PDYN

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
PDYN

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:8820

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
X02536

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_5_Locus:
20pter-p12

# Macromolecular_Interacting_Partner_5_SNPs:
rs6045819; rs2235751; rs910079; rs910080; rs742620; rs1883723; rs1418038; rs8123727; rs6045912; rs6035235; rs6045868; rs6035239; rs742622; rs2235755; rs2235754; rs6035237; rs742621; rs2235749; rs10485703; rs2223671; rs6045920; rs2235756; rs2281285; rs8120618; rs2235753; rs11908120; rs8117362; rs2235752; rs12480838; rs6035238; rs2179617; rs761245; rs12106276; rs2235750; rs1418037; rs8117115; rs1418036; rs8117349; rs6045850; rs6106013; rs7263708; rs8124319; rs13037430; rs1418035; rs8122988; rs6035222; rs2281284; rs6045824; rs1997794; rs8183670; rs6132153; rs3830064; rs6045800; rs6136637; rs35255728; rs35136558; rs6081502; rs3752930; rs5839927; rs36152783; rs6136643; rs35192454; rs6081509; rs6112214; rs6045860; rs35431673; rs7351823; rs1418039; rs35695665; rs3752931; rs5839928; rs6081538; rs6035248; rs6045862; rs28536675; rs6106016; rs35416914; rs35163154; rs35717071; rs28617253; rs28640019; rs4814824; rs6045788; rs6081543; rs11469592; rs6106046; rs6106045; rs2235748; rs35266033; rs6106044; rs11905152; rs16979714; rs34535593; rs6035207; rs1022563; rs10854244; rs11087273; rs11696688; rs11905823; rs11906837; rs11908349; rs16979691; rs16979959; rs16979996; rs2143542; rs2223672; rs2422668; rs6035281; rs6045733; rs6045761; rs6045784; rs6045937; rs6045938; rs6045941; rs6045955; rs6045971; rs6045979; rs6045985; rs6045988; rs6081457; rs6081462; rs6081465; rs6106005; rs6106006; rs6112179; rs6112180; rs6112181; rs6112184; rs6112196; rs6112202; rs6132182; rs6136667; rs7263324; rs7264572; rs7272891; rs7363153

# Macromolecular_Interacting_Partner_5_General_References:
6316163; 11780052; 9047294

# Macromolecular_Interacting_Partner_5_References:
15813929; 15893579; 16139809; 16325000

# Macromolecular_Interacting_Partner_6_ID:
8065

# Macromolecular_Interacting_Partner_6_Name:
5-hydroxytryptamine 1A receptor

# Macromolecular_Interacting_Partner_6_Synonyms:
5-HT-1A; Serotonin receptor 1A; 5- HT1A; G-21

# Macromolecular_Interacting_Partner_6_Gene_Name:
HTR1A

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>5hydroxytryptamine 1A receptor
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
422

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
46107

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
9.05

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
37-62
74-98
110-132
153-178
192-217
346-367
379-403

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
189928

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
5HT1A_HUMAN (P08908)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
HTR1A

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
HTR1A

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:5286

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1266 bp
ATGGATGTGCTCAGCCCTGGTCAGGGCAACAACACCACATCACCACCGGCTCCCTTTGAG
ACCGGCGGCAACACTACTGGTATCTCCGACGTGACCGTCAGCTACCAAGTGATCACCTCT
CTGCTGCTGGGCACGCTCATCTTCTGCGCGGTGCTGGGCAATGCGTGCGTGGTGGCTGCC
ATCGCCTTGGAGCGCTCCCTGCAGAACGTGGCCAATTATCTTATTGGCTCTTTGGCGGTC
ACCGACCTCATGGTGTCGGTGTTGGTGCTGCCCATGGCCGCGCTGTATCAGGTGCTCAAC
AAGTGGACACTGGGCCAGGTAACCTGCGACCTGTTCATCGCCCTCGACGTGCTGTGCTGC
ACCTCATCCATCTTGCACCTGTGCGCCATCGCGCTGGACAGGTACTGGGCCATCACGGAC
CCCATCGACTACGTGAACAAGAGGACGCCCCGGCCGCGTGCGCTCATCTCGCTCACTTGG
CTTATTGGCTTCCTCATCTCTATCCCGCCCATCCTGGGCTGGCGCACCCCGGAAGACCGC
TCGGACCCCGACGCATGCACCATTAGCAAGGATCATGGCTACACTATCTATTCCACCTTT
GGAGCTTTCTACATCCCGCTGCTGCTCATGCTGGTTCTCTATGGGCGCATATTCCGAGCT
GCGCGCTTCCGCATCCGCAAGACGGTCAAAAAGGTGGAGAAGACCGGAGCGGACACCCGC
CATGGAGCATCTCCCGCCCCGCAGCCCAAGAAGAGTGTGAATGGAGAGTCGGGGAGCAGG
AACTGGAGGCTGGGCGTGGAGAGCAAGGCTGGGGGTGCTCTGTGCGCCAATGGCGCGGTG
AGGCAAGGTGACGATGGCGCCGCCCTGGAGGTGATCGAGGTGCACCGAGTGGGCAACTCC
AAAGAGCACTTGCCTCTGCCCAGCGAGGCTGGTCCTACCCCTTGTGCCCCCGCCTCTTTC
GAGAGGAAAAATGAGCGCAACGCCGAGGCGAAGCGCAAGATGGCCCTGGCCCGAGAGAGG
AAGACAGTGAAGACGCTGGGCATCATCATGGGCACCTTCATCCTCTGCTGGCTGCCCTTC
TTCATCGTGGCTCTTGTTCTGCCCTTCTGCGAGAGCAGCTGCCACATGCCCACCCTGTTG
GGCGCCATAATCAATTGGCTGGGCTACTCCAACTCTCTGCTTAACCCCGTCATTTACGCA
TACTTCAACAAGGACTTTCAAAACGCGTTTAAGAAGATCATTAAGTGTAACTTCTGCCGC
CAGTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
M28269

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_6_Locus:
5q11.2-q13

# Macromolecular_Interacting_Partner_6_SNPs:
rs6294; rs878567; rs6295; rs749098; rs6449693; rs1799921; rs1800043; rs1800042; rs1799920; rs1800041; rs1800044; rs34979174; rs34814950; rs1800046; rs1800045; rs10052087; rs1800047; rs10042486; rs10046068; rs10062933; rs10085024; rs1048281; rs13163975; rs13361335; rs13436914; rs1364043; rs1423691; rs4289519; rs4521432; rs6878612; rs7448024; rs749099; rs918643; rs968554; rs970453

# Macromolecular_Interacting_Partner_6_General_References:
3041227; 1766875; 8393041; 3138543; 7755630; 9754630

# Macromolecular_Interacting_Partner_6_References:
15791634; 16817869; 16959959

# Macromolecular_Interacting_Partner_7_ID:
8301

# Macromolecular_Interacting_Partner_7_Name:
Glutamate receptor 1 precursor

# Macromolecular_Interacting_Partner_7_Synonyms:
GluR-1; GluR-A; GluR-K1; Glutamate receptor ionotropic, AMPA 1; AMPA-selective glutamate receptor 1

# Macromolecular_Interacting_Partner_7_Gene_Name:
GRIA1

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Glutamate receptor 1 precursor
MQHIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQID
IVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQ
FVLQLRPELQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTT
TEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDL
NKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVM
AEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGR
RTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYV
MLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGE
LVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW
MCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQ
QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIA
YGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLES
TMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKW
WYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMK
GFCLIPQQSINEAIRTSTLPRNSGAGASSGGSGENGRVVSHDFPKSMQSIPCMSHSSGMP
LGATGL

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
906

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
101507

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
7.78

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  transporter activity
Function:  ion transporter activity
Function:  ion channel activity
Function:  ligand-gated ion channel activity
Function:  extracellular ligand-gated ion channel activity
Function:  excitatory extracellular ligand-gated ion channel activity
Function:  glutamate-gated ion channel activity
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  glutamate receptor activity
Function:  ionotropic glutamate receptor activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) > glutamate > kainate

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF01094:ANF_receptor;
PF00060:Lig_chan

# Macromolecular_Interacting_Partner_7_Signals:
1-18

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
537-557
585-605
618-638
806-826

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
183281

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
GRIA1_HUMAN (P42261)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
GRIA1

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
GRIA1

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:4571

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>2724 bp
ATGCAGCACATTTTTGCCTTCTTCTGCACCGGTTTCCTAGGCGCGGTAGTAGGTGCCAAT
TTCCCCAACAATATCCAGATCGGGGGATTATTTCCAAACCAGCAGTCACAGGAACATGCT
GCTTTTAGATTTGCTTTGTCGCAACTCACAGAGCCCCCGAAGCTGCTCCCCCAGATTGAT
ATTGTGAACATCAGCGACAGCTTTGAGATGACCTATAGATTCTGTTCCCAGTTCTCCAAA
GGAGTCTATGCCATCTTTGGGTTTTATGAACGTAGGACTGTCAACATGCTGACCTCCTTT
TGTGGGGCCCTCCACGTCTGCTTCATTACGCCGAGCTTTCCCGTTGATACATCCAATCAG
TTTGTCCTTCAGCTGCGCCCTGAACTGCAGGATGCCCTCATCAGCATCATTGACCATTAC
AAGTGGCAGAAATTTGTCTACATTTATGATGCCGACCGGGGCTTATCCGTCCTGCAGAAA
GTCCTGGATACAGCTGCTGAGAAGAACTGGCAGGTGACAGCAGTCAACATCTTGACAACC
ACAGAGGAGGGATACCGGATGCTCTTTCAGGACCTGGAGAAGAAAAAGGAGCGGCTGGTG
GTGGTGGACTGTGAATCAGAACGCCTCAATGCTATCTTGGGCCAGATTATAAAGCTAGAG
AAGAATGGCATCGGCTACCACTACATTCTTGCAAATCTGGGCTTCATGGACATTGACTTA
AACAAATTCAAGGAGAGTGGCGCCAATGTGACAGGTTTCCAGCTGGTGAACTACACAGAC
ACTATTCCGGCCAAGATCATGCAGCAGTGGAAGAATAGTGATGCTCGAGACCACACACGG
GTGGACTGGAAGAGACCCAAGTACACCTCTGCGCTCACCTACGATGGGGTGAAGGTGATG
GCTGAGGCTTTCCAGAGCCTGCGGAGGCAGAGAATTGATATATCTCGCCGGGGGAATGCT
GGGGATTGTCTGGCTAACCCAGCTGTTCCCTGGGGCCAAGGGATCGACATCCAGAGAGCT
CTGCAGCAGGTGCGATTTGAAGGTTTAACAGGAAACGTGCAGTTTAATGAGAAAGGACGC
CGGACCAACTACACGCTCCACGTGATTGAAATGAAACATGACGGCATCCGAAAGATTGGT
TACTGGAATGAAGATGATAAGTTTGTCCCTGCAGCCACCGATGCCCAAGCTGGGGGCGAT
AATTCAAGTGTTCAGAACAGAACATACATCGTCACAACAATCCTAGAAGATCCTTATGTG
ATGCTCAAGAAGAACGCCAATCAGTTTGAGGGCAATGACCGTTACGAGGGCTACTGTGTA
GAGCTGGCGGCAGAGATTGCCAAGCACGTGGGCTACTCCTACCGTCTGGAGATTGTCAGT
GATGGAAAATACGGAGCCCGAGACCCTGACACGAAGGCCTGGAATGGCATGGTGGGAGAG
CTGGTCTATGGAAGAGCAGATGTGGCTGTGGCTCCCTTAACTATCACTTTGGTCCGGGAA
GAAGTTATAGATTTCTCCAAACCATTTATGAGTTTGGGGATCTCCATCATGATTAAAAAA
CCACAGAAATCCAAGCCGGGTGTCTTCTCCTTCCTTGATCCTTTGGCTTATGAGATTTGG
ATGTGCATTGTTTTTGCCTACATTGGAGTGAGTGTTGTCCTCTTCCTGGTCAGCCGCTTC
AGTCCCTATGAATGGCACAGTGAAGAGTTTGAGGAAGGACGGGACCAGACAACCAGTGAC
CAGTCCAATGAGTTTGGGATATTCAACAGTTTGTGGTTCTCCCTGGGAGCCTTCATGCAG
CAAGGATGTGACATTTCTCCCAGGTCCCTGTCTGGTCGCATCGTTGGTGGCGTCTGGTGG
TTCTTCACCTTAATCATCATCTCCTCATATACAGCCAATCTGGCCGCCTTCCTGACCGTG
GAGAGGATGGTGTCTCCCATTGAGAGTGCAGAGGACCTAGCGAAGCAGACAGAAATTGCC
TACGGGACGCTGGAAGCAGGATCTACTAAGGAGTTCTTCAGGAGGTCTAAAATTGCTGTG
TTTGAGAAGATGTGGACATACATGAAGTCAGCAGAGCCATCAGTTTTTGTGCGGACCACA
GAGGAGGGGATGATTCGAGTGAGGAAATCCAAAGGCAAATATGCCTACCTCCTGGAGTCC
ACCATGAATGAGTACATTGAGCAGCGGAAACCCTGTGACACCATGAAGGTGGGAGGTAAC
TTGGATTCCAAAGGCTATGGCATTGCAACACCCAAGGGGTCTGCCCTGAGAGGTCCCGTA
AACCTAGCGGTTTTGAAACTCAGTGAGCAAGGCGTCTTAGACAAGCTGAAAAGCAAATGG
TGGTACGATAAAGGGGAATGTGGAAGCAAGGACTCCGGAAGTAAGGACAAGACAAGCGCT
CTGAGCCTCAGCAATGTGGCAGGCGTGTTCTACATCCTGATCGGAGGACTTGGACTAGCC
ATGCTGGTTGCCTTAATCGAGTTCTGCTACAAATCCCGTAGTGAATCCAAGCGGATGAAG
GGTTTTTGTTTGATCCCACAGCAATCCATCAACGAAGCCATACGGACATCGACCCTCCCC
CGCAACAGCGCGGGCACGGCACCGAGCAGCGGCGGCAGTGGAGAGAATGGTCGGGTGGTC
AGCCATGACTTCCCCAAGTCCATGCAATCGATTCCTTGCATGAGCCACAGTTCAGGGATG
CCCTTGGGAGCCACGGGATTGTAA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
M64752

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_7_Locus:
5q33|5q31.1

# Macromolecular_Interacting_Partner_7_SNPs:
rs707176; rs778819; rs541518; rs1353081; rs1873908; rs2963953; rs874179; rs1493404; rs726877; rs2452801; rs1422883; rs1994862; rs1873910; rs488443; rs1552833; rs1873905; rs515709; rs1353082; rs514381; rs2963998; rs726876; rs1363678; rs1422884; rs1552834; rs2220780; rs889062; rs545098; rs572798; rs2910263; rs493844; rs778817; rs2963940; rs495703; rs2926869; rs778825; rs503525; rs1493395; rs2926856; rs889060; rs1422893; rs1422886; rs2963950; rs1493402; rs512193; rs1389288; rs1461224; rs1363672; rs1908099; rs1422895; rs1463746; rs1873907; rs812389; rs509757; rs517931; rs2926835; rs1363673; rs1422899; rs7735696; rs12519746; rs10075497; rs1422887; rs12515520; rs13172367; rs4958667; rs1466386; rs4958676; rs6890057; rs1077278; rs13174041; rs1493400; rs2910265; rs10463248; rs10477080; rs2963941; rs7720354; rs6859463; rs6580022; rs6866103; rs6580024; rs6864192; rs6580034; rs6866738; rs6580028; rs1551765; rs9324752; rs937210; rs1353084; rs3813470; rs7731734; rs4132124; rs6580038; rs10057454; rs10041275; rs11955821; rs982945; rs11746246; rs2963997; rs4958661; rs10477083; rs778831; rs1422894; rs2926836; rs2910269; rs10036436; rs487362; rs4365885; rs7709924; rs1461232; rs764604; rs1422889; rs2220779; rs1493388; rs6870761; rs1422888; rs1363675; rs4460184; rs1461227; rs4958345; rs6886847; rs7713717; rs6861065; rs2055082; rs4254956; rs10463334; rs7703304; rs11749754; rs479767; rs6580030; rs6580019; rs2926837; rs10463249; rs1864205; rs7714428; rs13174758; rs1559157; rs1077279; rs6580039; rs512983; rs10075495; rs12717883; rs7714611; rs4958671; rs11741791; rs1552835; rs1083562; rs778832; rs10067724; rs1422885; rs6890276; rs4403231; rs778821; rs4424038; rs524905; rs2926848; rs6889794; rs4958349; rs922235; rs10515695; rs7731586; rs10042081; rs10463335; rs4385264; rs6889909; rs11748500; rs6580031; rs7445323; rs11747288; rs4260727; rs778822; rs2963939; rs6580020; rs922234; rs4616951; rs472792; rs1540383; rs1826532; rs6897016; rs6580032; rs573496; rs1353086; rs2926838; rs509555; rs1463747; rs2220781; rs754596; rs517589; rs6893720; rs12152942; rs6898704; rs1381120; rs7727464; rs11744176; rs479946; rs1461231; rs11749611; rs4635983; rs10063691; rs1908100; rs6580033; rs6580036; rs10067262; rs1552836; rs480726; rs2042257; rs7708391; rs4273649; rs7711124; rs2964018; rs6580023; rs6893441; rs2201280; rs2910264; rs12515561; rs2964031; rs6881792; rs1389289; rs12522937; rs1493383; rs10515697; rs4336406; rs778827; rs7735784; rs514336; rs4958347; rs524610; rs11167641; rs12658202; rs1873906; rs1381119; rs12717878; rs6891987; rs13173910; rs3811984; rs1389286; rs867674; rs11743342; rs4415128; rs17592741; rs6891142; rs11748119; rs1363674; rs11956515; rs1461226; rs10057063; rs13358432; rs13155429; rs7724417; rs498858; rs3935764; rs12520732; rs11741511; rs17115020; rs4958351; rs3828595; rs7702033; rs6864226; rs1493399; rs10058464; rs6872498; rs576710; rs10071989; rs7707039; rs12520266; rs2910258; rs1428920; rs10515698; rs6879645; rs12153765; rs492014; rs11955628; rs4958672; rs1461233; rs6859491; rs11739206; rs7728380; rs7737906; rs10515699; rs1037892; rs12653379; rs7709884; rs12523051; rs4440419; rs17519054; rs778816; rs10065813; rs4502882; rs11742223; rs11748694; rs13186102; rs970078; rs754597; rs540375; rs6884414; rs11750700; rs1873903; rs13359676; rs10515690; rs11955520; rs559294; rs12153490; rs10041141; rs10476795; rs17591636; rs515887; rs17523165; rs1493397; rs10035262; rs7719292; rs4530817; rs10515689; rs11748184; rs7709205; rs4129128; rs4645377; rs1422898; rs518370; rs2964016; rs17114836; rs7717314; rs11745911; rs11741602; rs2963952; rs1586937; rs11750376; rs11741914; rs754594; rs9324756; rs17114876; rs7726883; rs1422897; rs10069739; rs6885981; rs10060737; rs17593426; rs502887; rs1493393; rs12515594; rs2195450; rs12522802; rs2910267; rs6891253; rs754595; rs2131564; rs10155614; rs17519558; rs1873909; rs4336409; rs1493398; rs7727515; rs11167639; rs1873904; rs2042256; rs7717329; rs6580018; rs2910260; rs17594729; rs10063732; rs12520227; rs12153489; rs11738883; rs10041179; rs12515622; rs12656103; rs549100; rs7724886; rs10054958; rs729329; rs17115018; rs6580021; rs17114681; rs12522373; rs17519810; rs7727479; rs13189947; rs11744124; rs13188509; rs4145160; rs12521769; rs11953799; rs11746196; rs17525192; rs6876314; rs9324755; rs17114692; rs10515691; rs1493385; rs5005058; rs11745937; rs9784658; rs12520758; rs12652927; rs17515380; rs10477084; rs10515688; rs1493396; rs4958344; rs2964025; rs17523221; rs2963999; rs2926847; rs12513963; rs17523047; rs17356099; rs17114975; rs10071736; rs4077374; rs13174063; rs17519656; rs521210; rs10051060; rs11952055; rs1363676; rs11746037; rs7443329; rs2926855; rs12655494; rs13168358; rs7712284; rs17114703; rs574071; rs918524; rs17114991; rs10515696; rs11748478; rs12515563; rs17115017; rs10057486; rs6580017; rs7356588; rs4128572; rs6878548; rs2963957; rs13354399; rs13164993; rs6881133; rs7712550; rs6896622; rs6881075; rs5005059; rs11167640; rs11958105; rs778823; rs4958668; rs11746811; rs10071714; rs6886614; rs4958659; rs4299782; rs5005057; rs4569925; rs2963944; rs6880024; rs6897621; rs10073988; rs12513984; rs4576205; rs4958670; rs6580037; rs542161; rs1363677; rs6876631; rs10070447; rs4377754; rs2964026; rs2963949; rs17518831; rs13359392; rs1353087; rs17615205; rs6875801; rs17114771; rs17115039; rs10515692; rs1552837; rs12518721; rs17593685; rs6897915; rs11954655; rs2910261; rs6858939; rs11744083; rs13358769; rs11741924; rs7736182; rs17524751; rs778833; rs10515693; rs9324750; rs7712652; rs11747180; rs2963954; rs13169333; rs17588123; rs17523061; rs17096210; rs2055083; rs10070086; rs11747659; rs4958663; rs7446886; rs489572; rs6893650; rs778820; rs13180912; rs778830; rs10058928; rs716518; rs10060095; rs6876451; rs12521489; rs7446593; rs7718473; rs10072570; rs11167637; rs13190414; rs6863948; rs1463748; rs12520252; rs17114995; rs7731986; rs889061; rs12652434; rs2216649; rs1493386; rs11749744; rs1422892; rs7707530; rs6886378; rs6883902; rs2963946; rs1353091; rs6863632; rs4323276; rs10077872; rs11742288; rs13166919; rs11743325; rs12187326; rs2910266; rs778815; rs12520178; rs4533948; rs13170232; rs1862409; rs7445290; rs7737585; rs10477082; rs2926854; rs10037684; rs12654700; rs13186237; rs1422890; rs2926849; rs566474; rs10078701; rs778829; rs12658841; rs4334936; rs778824; rs13167714; rs12655136; rs1422891; rs34330754; rs867673; rs6861421; rs17115067; rs2964030; rs716517; rs10036623; rs17114874; rs17114868; rs17518292; rs10038377; rs9687223; rs7731793; rs11745294; rs1552838; rs11741942; rs17521666; rs17115197; rs17519418; rs17114807; rs970077; rs6863372; rs7715304; rs778828; rs7702986; rs17115052; rs547166; rs17115057; rs10515694; rs12521029; rs12659290; rs1353090; rs2963945; rs10058764; rs17590185; rs10035289; rs10065287; rs17114677; rs6881762; rs7733278; rs17515563; rs1389287; rs13360767; rs4333368; rs6861158; rs10078026; rs547047; rs10053447; rs2926853; rs17115256; rs488009; rs4958350; rs17592909; rs17520467; rs4958675; rs13358629; rs7731539; rs17518278; rs2926850; rs548616; rs9686410; rs2963942; rs6580035; rs6889894; rs778818; rs6861449; rs10477081; rs6421143; rs12514755; rs17517444; rs545006; rs11959282; rs12153160; rs1389284; rs17523488; rs1493401; rs13180804; rs17519775; rs11742547; rs17114831; rs1353088; rs10062862; rs7736304; rs10079744; rs17515584; rs17519935; rs9686257; rs6884728; rs918523; rs13167420; rs13173300; rs10059401; rs542844; rs11951557; rs10060616; rs17591692; rs17594464; rs17114887; rs4318827; rs10071192; rs17114870; rs7736995; rs12153497; rs10075339; rs2964024; rs7723931; rs17589518; rs2112738; rs2926852; rs1493405; rs1463745; rs2963943; rs9324754; rs34181741; rs9686415; rs7726352; rs7733641; rs17519306; rs1353083; rs10053570; rs4958660; rs11747810; rs17521172; rs6867011; rs1493389; rs12517168; rs7716290; rs17591414; rs1994860; rs7731561; rs7736143; rs10476797; rs10073936; rs6890399; rs12054909; rs17114806; rs2126165; rs10072952; rs13162978; rs13168692; rs898710; rs6876745; rs17115209; rs13436695; rs13189836; rs1493392; rs937209; rs6580040; rs10071612; rs11741081; rs11950598; rs17114750; rs1862408; rs10053518; rs778826; rs12189130; rs6898022; rs11958138; rs10073844; rs11948119; rs478962; rs10041424; rs11746923; rs12055179; rs9687836; rs9687829; rs12153502; rs6896076; rs11167636; rs9324751; rs10071510; rs17515793; rs1389285; rs9324749; rs17589588; rs2926851; rs1461228; rs6580025; rs724000; rs1493391; rs9687441; rs6865676; rs17114830; rs1973372; rs17519446; rs2963996; rs7707437; rs475583; rs11954428; rs13164049; rs10463336; rs7731036; rs17114805; rs4277964; rs490922; rs1493403; rs17115211; rs10071300; rs1461230; rs17115251; rs7711758; rs17114847; rs9686702; rs10036541; rs10036589; rs1077276; rs7736016; rs571940; rs10476796; rs10065176; rs13167389; rs7712420; rs11745872; rs6876587; rs2910268; rs17519383; rs13168229; rs11740548; rs10035143; rs1461225; rs9687835; rs11748890; rs17114838; rs9324748; rs6580029; rs17114798; rs10075579; rs7715366; rs9687431; rs12189362; rs17515709; rs2963948; rs17518607; rs548916; rs548294; rs3792766; rs13186047; rs34795646; rs13186365; rs28758858; rs13166161; rs13166146; rs13186534; rs13186241; rs13166438; rs28404146; rs13166442; rs13166679; rs13186216; rs13166321; rs6875572; rs13166143; rs34611747; rs35078210; rs1493387; rs10040991; rs34835974; rs34339156; rs35423691; rs35293224; rs35905830; rs529093; rs35574907; rs34291322; rs1841554; rs10058930; rs35097496; rs9324757; rs6873692; rs34442949; rs35924323; rs35210828; rs35460121; rs13164918; rs13189903; rs35080272; rs35168528; rs12523009; rs35102561; rs35302517; rs34728801; rs3898371; rs35443126; rs2059897; rs35429957; rs11341460; rs28630753; rs11358453; rs13179758; rs28544355; rs36022490; rs3036985; rs985998; rs6878074; rs11409143; rs10037403; rs34511642; rs34003740; rs7704432; rs4485972; rs34746264; rs6878093; rs5872342; rs34398988; rs10042195; rs6891053; rs1493390; rs7713771; rs17114851; rs1110100; rs35319575; rs6891901; rs13166863; rs10542435; rs7720382; rs17115015; rs35637954; rs515808; rs35697272; rs35455708; rs11394164; rs10080057; rs11316162; rs10041308; rs4958346; rs5872325; rs11319462; rs33969374; rs13179613; rs3076747; rs5872331; rs11741455; rs35534347; rs13167926; rs34702193; rs34260448; rs35147393; rs34414426; rs34603108; rs28513256; rs10037591; rs10607539; rs34433313; rs28778434; rs34201746; rs2201279; rs10653929; rs35552255; rs13190171; rs35035880; rs35359661; rs11951770; rs7711712; rs34343406; rs34493331; rs35070753; rs35734624; rs34530863; rs34143735; rs7445627; rs11743471; rs34521182; rs6865256; rs5872346; rs35305514; rs3037013; rs3749656; rs10074628; rs34915851; rs34171571; rs7714424; rs10596596; rs35815197; rs35611523; rs35073762; rs5872324; rs5009593; rs34349565; rs35765489; rs6877910; rs3064336; rs6880600; rs1493384; rs34144562; rs2042255; rs13163026; rs35593460; rs11409539; rs35844295; rs34102415; rs5872338; rs34549524; rs35279236; rs13156936; rs5872329; rs33960409; rs13184513; rs34967320; rs3811982; rs35562676; rs13166807; rs13156369; rs35414667; rs34227171; rs5872317; rs4997014; rs34299863; rs34778965; rs4032985; rs12054983; rs11348503; rs13174867; rs7448087; rs2910259; rs34066698; rs10570191; rs35891592; rs34899783; rs2035947; rs5872319; rs35689901; rs5872341; rs34215310; rs13361388; rs5872336; rs34910484; rs35942304; rs35448990; rs28630892; rs6149299; rs12332591; rs11351483; rs34025038; rs35537343; rs34511192; rs28695255; rs35088432; rs34497962; rs34366052; rs35701544; rs28421461; rs34694246; rs34554999; rs33936096; rs7716762; rs35930818; rs5872328; rs10677490; rs11426974; rs2350536; rs11324345; rs4958348; rs13183191; rs34212051; rs4958665; rs1428921; rs11385736; rs564700; rs4997016; rs35189374; rs918522; rs35686000; rs35880054; rs10546900; rs10571183; rs34383576; rs34680413; rs34941395; rs34637523; rs36119149; rs13166799; rs10525246; rs35300119; rs34487335; rs3037009; rs28438891; rs34901245; rs5872339; rs13176835; rs6863676; rs34279450; rs34244660; rs34027207; rs35431228; rs5872323; rs10550235; rs6898976; rs36038833; rs6886353; rs5872345; rs4607394; rs35786011; rs35710163; rs34230296; rs12653672; rs35071937; rs34847464; rs11318389; rs35509403; rs34918289; rs5872320; rs5872332; rs2201278; rs34674446; rs13163252; rs28843686; rs10653928; rs2640546; rs13165311; rs28592925; rs28377072; rs11441700; rs34449755; rs11749645; rs5872318; rs11959680; rs35298036; rs4997015; rs11957555; rs35636352; rs41290597; rs36154928; rs34626979; rs2910262; rs34440726; rs35963309; rs10039178; rs28723572; rs34712347; rs35632518; rs34049703; rs3811983; rs13168589; rs5872335; rs35199031; rs878040; rs35656334; rs35592511; rs12520128; rs36124507; rs34784688; rs35033669; rs28637689; rs35402981; rs35686288; rs34429206; rs2934133; rs34418594; rs35279706; rs3036983; rs35995011; rs34414493; rs13178098; rs34162143; rs5872330; rs13360820; rs1422896; rs34700229; rs35991677; rs4318826; rs34009956; rs35604199; rs6871841; rs17594680; rs35795628; rs6895523; rs2055081; rs36016760; rs35112693; rs11951518; rs35542417; rs5872327; rs35680654; rs34133077; rs4958678; rs28542021; rs28806177; rs7713446; rs9687781; rs12522329; rs35462078; rs33937712; rs35246460; rs3841128; rs34732172; rs35649390; rs35773650; rs35490731; rs5872333; rs10604138; rs11741456; rs35290764; rs12653393; rs35917034; rs28783685; rs4507544; rs28607686; rs34753305; rs12658789; rs35042051; rs11410968; rs34083449; rs28852118; rs35743924; rs6868021; rs4535508; rs7442922; rs4547968; rs34777842; rs6877129; rs35079508; rs34483973; rs1908101; rs34444212; rs3064339; rs35585121; rs7726544; rs6875355; rs35997851; rs10694156; rs34955474; rs34784715; rs937211; rs34390714; rs10586598; rs3037011; rs34029119; rs13161908; rs1353089; rs3064338; rs11394407; rs17524506; rs28750997; rs35068409; rs36137894; rs34160886; rs34011202; rs35103900; rs566577; rs35830203; rs34451726; rs1896780; rs13170351; rs34584866; rs41373946; rs35427120; rs4644006; rs35305526; rs35226757; rs34811569; rs35241435; rs7720770; rs28616604; rs13167051; rs34821149; rs2963955; rs36003151; rs34483272; rs575497; rs10580294; rs10570190; rs10434714; rs34928321; rs34336356; rs7736850; rs6875506; rs10477085; rs4958664; rs6893888; rs35035949; rs34919007; rs35327607; rs35619395; rs35189441; rs36081349; rs35355342; rs2112737; rs10690637; rs34722108; rs10061287; rs10561537; rs3064317; rs34784723; rs35041796; rs28870431; rs35301723; rs4958674; rs35984965; rs34286550; rs35578276; rs34694482; rs11362282; rs529090; rs34058956; rs10038916; rs11954176; rs34688484; rs35951854; rs4958677; rs2350537; rs35994442; rs5872322; rs41290595; rs11351469; rs36023049; rs28701828; rs4958673; rs1077277; rs35272128; rs34801610; rs35333154; rs2934134; rs6869815; rs35070797; rs35740084; rs10631988; rs12660059; rs2055080; rs34649832; rs1389290; rs35925183; rs1994861; rs10594353; rs6881652; rs35260068; rs34936450; rs34794759; rs35958716; rs5017857; rs34708615; rs35228355; rs13185238; rs7737904; rs35915112; rs5872334; rs10079274; rs11749088; rs10710677; rs35407813; rs2216650; rs1862410; rs11290446; rs6891885; rs35294052; rs35092343; rs35616395; rs13186852; rs36086441; rs34088910; rs34450775; rs41290599; rs35797603; rs5872326; rs1350803; rs484676; rs35437029; rs4033113; rs13166598; rs4613769; rs2963956; rs13156071; rs7730509; rs28627450; rs33998489; rs28892385; rs34981000; rs11399181; rs34845341; rs3064337; rs3749655; rs9324753; rs5872337; rs1493394; rs34629938; rs36117494; rs12516326; rs4348270; rs7713730; rs35492970; rs36229919; rs28620484; rs35583736; rs11952393; rs10691038; rs3792767; rs11739617; rs35595140; rs11738507; rs35614197; rs34597943; rs35403476; rs5872321; rs35540964; rs577278; rs6881489; rs12374495; rs6888086; rs13186637; rs35203202; rs10610110; rs6867564; rs34422555; rs4958662; rs11394199; rs35777116; rs34623069; rs34714217; rs41436549; rs36129955; rs7718508; rs34507407; rs35272297; rs28595320; rs28764787; rs34680297; rs34295816; rs10074876; rs10515700; rs11742573; rs11951398; rs1541832; rs17525311; rs2926831; rs2926832; rs2926833; rs2926834; rs2963947; rs2964013; rs2964015; rs34367235; rs475379; rs497956; rs513046; rs525208; rs531648; rs560151; rs561961; rs576969; rs578772; rs6580041; rs6880984; rs6882575; rs7736176; rs930101; rs9324759

# Macromolecular_Interacting_Partner_7_General_References:
1652753; 1320959; 1311100

# Macromolecular_Interacting_Partner_7_References:
15223297; 17053970; 17113046

# Macromolecular_Interacting_Partner_8_ID:
8046

# Macromolecular_Interacting_Partner_8_Name:
Sodium-dependent dopamine transporter

# Macromolecular_Interacting_Partner_8_Synonyms:
DA transporter; DAT

# Macromolecular_Interacting_Partner_8_Gene_Name:
SLC6A3

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Sodiumdependent dopamine transporter
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
620

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
68496

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  transporter activity
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
Function:  dopamine:sodium symporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_8_Signals:
None

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
69-89
96-116
140-160
238-256
265-282
318-335
347-368
401-420
447-465
481-501
522-541
560-578

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
553260

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
SC6A3_HUMAN (Q01959)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
SLC6A3

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
SLC6A3

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:11049

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>278 bp
GCTGCACTATCTCTTCTCCTCCTTCACCACGGAGCTCCCCTGGATCCACTGCAACAACTC
CTGGAACAGCCCCAACTGCTCGGATGCCCATCCTGGTGACTCCAGTGGAGACAGCTCGGG
CCTCAACGACACTTTTGGGACCACACCTGCTGCCGAGTACTTTGAACGTGGCGTGCTGCA
CCTCCACCAGAGCCATGGCATCGACGACCTGGGGCCTCCGCGGTGGCAGCTCACAGCCTG
CCTGGTGCTGGTCATCGTGCTGCTCTACTTCAGCCTCT

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
M96670

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_8_Locus:
5p15.3

# Macromolecular_Interacting_Partner_8_SNPs:
rs2270912; rs6349; rs8179034; rs6347; rs6880875; rs8179035; rs28363072; rs6348; rs27072; rs1042098; rs403798; rs3797200; rs7732456; rs1809939; rs11564774; rs16877691; rs28363170; rs28363174; rs1042128; rs28363166; rs9312841; rs6876890; rs28363168; rs9312842; rs2975284; rs461753; rs460700; rs463379; rs27047; rs456082; rs37021; rs461677; rs458334; rs37022; rs2963253; rs10072058; rs11133767; rs40184; rs2975292; rs11737901; rs6869645; rs10052985; rs2617577; rs460000; rs459141; rs410209; rs2042449; rs456774; rs462523; rs458609; rs464049; rs3776512; rs3834250; rs250686; rs11564759; rs11564762; rs460007; rs462053; rs4975646; rs11564767; rs8179031; rs427284; rs465130; rs16878300; rs10053602; rs11564758; rs2617605; rs8179029; rs3776511; rs11564771; rs2550936; rs10155607; rs6876225; rs487781; rs37020; rs429699; rs536616; rs365663; rs246997; rs10052016; rs11133778; rs2245660; rs11564764; rs464061; rs393795; rs466630; rs10040882; rs3776513; rs11133768; rs457894; rs465989; rs409588; rs10074171; rs11564769; rs403636; rs420422; rs27048; rs458632; rs3756451; rs250682; rs28363080; rs28382230; rs11564766; rs28363151; rs28363098; rs2927675; rs456645; rs28363074; rs428280; rs11564763; rs28363085; rs10475006; rs28363160; rs28382252; rs410481; rs28363155; rs2963252; rs11564773; rs28363124; rs28363114; rs28382247; rs2963239; rs28363141; rs28382245; rs28363119; rs2735917; rs2911492; rs2927676; rs2963242; rs28363090; rs250681; rs28363152; rs28363142; rs4975547; rs460934; rs11133770; rs11951672; rs28363115; rs28363120; rs2975291; rs4975641; rs458860; rs28363161; rs28363156; rs28382246; rs28382248; rs28363086; rs40358; rs28363101; rs28363138; rs28382251; rs3842031; rs28363106; rs1048955; rs28363129; rs28363125; rs11953287; rs2937643; rs3776514; rs28382228; rs28363083; rs6886753; rs28363153; rs11564768; rs11564761; rs28363111; rs2173947; rs28363116; rs2927677; rs28363149; rs28363154; rs28363139; rs457702; rs28363109; rs28363126; rs28363157; rs28363159; rs28363133; rs28382242; rs28742608; rs28363077; rs28382254; rs250684; rs28382237; rs28363079; rs28363089; rs28382244; rs28363082; rs10068876; rs10051340; rs1048953; rs378607; rs11564772; rs28382257; rs28382234; rs2652514; rs28363117; rs3056480; rs13169612; rs250683; rs11564765; rs13161905; rs28363104; rs4975638; rs2975293; rs28363078; rs28363092; rs10036478; rs28363099; rs28363076; rs2963241; rs28363113; rs10064525; rs11133762; rs2617596; rs6413429; rs12516948; rs11564751; rs2652511; rs6866570; rs28363179; rs28363178; rs3863145; rs28363185; rs28363181; rs28363177; rs6345; rs28364997; rs28364996; rs35337610; rs28364998; rs28363169; rs1042130; rs28363171; rs41282613; rs28363172; rs28363175; rs426305; rs1042125; rs11564775; rs1042132; rs1042129; rs2652504; rs28363167; rs41280377; rs28363173; rs34377601; rs2735933; rs28363069; rs11738968; rs34840629; rs2735910; rs28656867; rs2550929; rs459092; rs28382256; rs28382235; rs3836790; rs2927683; rs2975290; rs2963240; rs1677431; rs2652527; rs28363091; rs2963246; rs2652516; rs28382241; rs2652520; rs10582066; rs638964; rs11362775; rs10569377; rs28363102; rs13178805; rs2735913; rs10071624; rs2735929; rs28363131; rs35354514; rs2617611; rs2735922; rs2550924; rs2652519; rs2735914; rs36154293; rs12332091; rs11741877; rs28363070; rs28382239; rs28363087; rs28382226; rs2937642; rs439028; rs28363097; rs423091; rs420334; rs28363107; rs28742609; rs2963244; rs28363122; rs10078288; rs2550938; rs34389905; rs2652532; rs2249823; rs28382240; rs2550958; rs2652524; rs2735926; rs2550928; rs28382236; rs418265; rs28363165; rs11564760; rs2927682; rs13186941; rs28363148; rs11442679; rs34110245; rs501965; rs28363068; rs3776508; rs28363110; rs13171176; rs2550937; rs2859605; rs35841133; rs34211901; rs28380002; rs250685; rs2652525; rs28363084; rs2550933; rs28363136; rs2735932; rs2735916; rs34128392; rs28382249; rs183125; rs2963250; rs28363073; rs371742; rs28382255; rs2963247; rs34976394; rs11273210; rs2617609; rs11564770; rs2617608; rs34049355; rs6880255; rs638577; rs2249815; rs438260; rs28363096; rs11741780; rs2735923; rs13155096; rs36082016; rs34639188; rs2617612; rs168682; rs181776; rs2975285; rs28419783; rs34389111; rs369333; rs28363118; rs28363132; rs10069101; rs28382225; rs28363146; rs28364999; rs27049; rs13163094; rs34946486; rs28407730; rs2652531; rs409928; rs36050264; rs28363158; rs28382231; rs2617580; rs28363164; rs2550932; rs2652517; rs2550923; rs4975640; rs624466; rs2911491; rs28363093; rs2652529; rs2550922; rs2617576; rs13155226; rs2735915; rs28382243; rs10063564; rs28363143; rs28382253; rs2652526; rs2735927; rs2735909; rs28363100; rs28363137; rs37014; rs181775; rs3836789; rs2735920; rs2735931; rs2550926; rs11306694; rs2859606; rs28363121; rs28382258; rs2550927; rs2652518; rs28382229; rs452603; rs28363105; rs2550931; rs2963248; rs34079488; rs28363147; rs2652528; rs10569379; rs2937647; rs35563174; rs28382232; rs28363162; rs2652530; rs2975286; rs2735924; rs2927681; rs2652521; rs34542332; rs28382224; rs6879732; rs2937644; rs2617606; rs3776510; rs2975287; rs185034; rs29001606; rs28363134; rs28363095; rs3822458; rs2617579; rs386538; rs384907; rs9312865; rs28363103; rs624846; rs28382227; rs35190238; rs13162153; rs28363140; rs28363075; rs28382223; rs2652523; rs2735918; rs10069463; rs2963249; rs10072809; rs417608; rs2963251; rs35230954; rs2550935; rs28363128; rs2550930; rs28363088; rs35762146; rs10569378; rs11344041; rs2927684; rs1614919; rs5865370; rs11738604; rs10475005; rs380689; rs2735930; rs375636; rs28363112; rs2859607; rs28363145; rs430512; rs2975289; rs2735928; rs2963245; rs2735921; rs28363144; rs28651372; rs2735908; rs28382233; rs2550959; rs11745189; rs9312866; rs2617607; rs2652515; rs28363108; rs13357809; rs2249538; rs2550925; rs28382250; rs35789472; rs41282615; rs28363123; rs28363130; rs2735911; rs2550934; rs28363127; rs28363081; rs28363071; rs6895518; rs462293; rs401235; rs410246; rs28363163; rs460819; rs2937641; rs28363094; rs6862677; rs2735925; rs2617610; rs2652522; rs2927680; rs408023; rs368273; rs909242; rs28363150; rs451561; rs461854; rs2975288; rs28363135; rs2617578; rs2735852; rs28969507; rs2550957; rs2617598; rs28363183; rs2937637; rs28363184; rs2735853; rs4029364; rs34076103; rs28363180; rs4029363; rs28363176; rs28363186; rs2617597; rs27995; rs28363182; rs10051714; rs10063727; rs10064219; rs10079348; rs11742490; rs11744775; rs12332463; rs12516758; rs13164174; rs13189021; rs1478434; rs2078247; rs2254255; rs2254408; rs2270913; rs2447848; rs2447849; rs2447850; rs2471921; rs2471926; rs2516290; rs2516291; rs2550939; rs2550948; rs2550949; rs2550950; rs2550951; rs2550952; rs2550953; rs2550954; rs2550955; rs2550956; rs2550965; rs2550966; rs2550967; rs2617588; rs2617589; rs2617590; rs2617591; rs2617592; rs2617594; rs2617599; rs2617600; rs2617601; rs2617602; rs2617603; rs2617604; rs2652508; rs2652510; rs27073; rs27074; rs2735847; rs2735848; rs2735849; rs2735850; rs2735851; rs2735855; rs2735856; rs2735857; rs2735934; rs2859604; rs2911493; rs2937629; rs2937635; rs2963238; rs2963256; rs2975225; rs2981359; rs3756450; rs3776485; rs456323; rs464528; rs6346; rs6350; rs8179023

# Macromolecular_Interacting_Partner_8_General_References:
1359373; 1406597; 8302271; 9300814; 10889531; 11304827; 7637582; 1353885; 11343649; 10391209

# Macromolecular_Interacting_Partner_8_References:
15390012; 15471835; 15590952; 16081470

# Macromolecular_Interacting_Partner_9_ID:
7984

# Macromolecular_Interacting_Partner_9_Name:
Synaptic vesicular amine transporter

# Macromolecular_Interacting_Partner_9_Synonyms:
Monoamine transporter; Vesicular amine transporter 2; VAT2; Solute carrier family 18 member 2

# Macromolecular_Interacting_Partner_9_Gene_Name:
SLC18A2

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Synaptic vesicular amine transporter
MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEI
QTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSE
DKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSS
SYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGS
VLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGS
ICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLC
ALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGS
VYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKM
AILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
514

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
55714

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
5.91

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_9_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_9_Specific_Function:
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF07690:MFS_1

# Macromolecular_Interacting_Partner_9_Signals:
1-37

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
292335

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
VMAT2_HUMAN (Q05940)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
SLC18A2

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
SLC18A2

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:10935

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Cytoplasmic vesicle; cytoplasmic vesicle membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>1545 bp
ATGGCCCTGAGCGAGCTGGCGCTGGTCCGCTGGCTGCAGGAGAGCCGCCGCTCGCGGAAG
CTCATCCTGTTCATCGTGTTCCTGGCGCTGCTGCTGGACAACATGCTGCTCACTGTCGTG
GTCCCCATCATCCCAAGTTATCTGTACAGCATTAAGCATGAGAAGAATGCTACAGAAATC
CAGACGGCCAGGCCAGTGCACACTGCCTCCATCTCAGACAGCTTCCAGAGCATCTTCTCC
TATTATGATAACTCGACTATGGTCACCGGGAATGCTACCAGAGACCTGACACTTCATCAG
ACCGCCACACAGCACATGGTGACCAACGCGTCCGCTGTTCCTTCCGACTGTCCCAGTGAA
GACAAAGACCTCCTGAATGAAAACGTGCAAGTTGGTCTGTTGTTTGCCTCGAAAGCCACC
GTCCAGCTCATCACCAACCCTTTCATAGGACTACTGACCAACAGAATTGGCTATCCAATT
CCCATATTTGCGGGATTCTGCATCATGTTTGTCTCAACAATTATGTTTGCCTTCTCCAGC
AGCTATGCCTTCCTGCTGATTGCCAGGTCGCTGCAGGGCATCGGCTCGTCCTGCTCCTCT
GTGGCTGGGATGGGCATGCTTGCCAGTGTCTACACAGATGATGAAGAGAGAGGCAACGTC
ATGGGAATCGCCTTGGGAGGCCTGGCCATGGGGGTCTTAGTGGGCCCCCCCTTCGGGAGT
GTGCTCTATGAGTTTGTGGGGAAGACGGCTCCGTTCCTGGTGCTGGCCGCCCTGGTACTC
TTGGATGGAGCTATTCAGCTCTTTGTGCTCCAGCCGTCCCGGGTGCAGCCAGAGAGTCAG
AAGGGGACACCCCTAACCACGCTGCTGAAGGACCCGTACATCCTCATTGCTGCAGGCTCC
ATCTCCTTTGCAAACATGGGCATCGCCATGCTGGAGCCAGCCCTGCCCATCTGGATGATG
GAGACCATGTGTTCCCGCAAGTGGCAGCTGGGCGTTGCCTTCTTGCCAGCTAGTATCTCT
TATCTCATTGGAACCAATATTTTTGGGATACTTGCACACACAATGGGGAGGTGGCTTTGT
GCTCTTCTGGGAATGATAATTGTTGGAGTCAGCATTTTATGTATTCCATTTCCAAAAAAC
ATTTATGGACTCATAGCTCCGAACTTTGGAGTTGGTTTTGCAAATGGAATGGTGGATTCG
TCAATGATGCCTATCATGGGCTACCTCGTAGACCTGCGGCACGTGTCCGTCTATGGGAGT
GTGTACGCCATTGCGGATGTGGCATTTTGTATGGGGTATGCTATAGGTCCTTCTGCTGGT
GGTGCTATTGCAAAGGCAATTGGATTTCCATGGCTCATGACAATTATTGGGATAATTGAT
ATTCTTTTTGCCCCTCTCTGCTTTTTTCTTCGAAGTCCACCTGCCAAAGAAGAAAAAATG
GCTATTCTCATGGATCACAACTGCCCTATTAAAACAAAAATGTACACTCAGAATAATATC
CAGTCATATCCGATAGGTGAAGATGAAGAATCTGAAAGTGACTGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
L09118

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_9_Locus:
10q25

# Macromolecular_Interacting_Partner_9_SNPs:
rs363387; rs363388; rs363411; rs14240; rs10377; rs363280; rs2244375; rs363278; rs363272; rs363271; rs363337; rs363226; rs2015586; rs3523; rs363227; rs363276; rs363275; rs363262; rs363224; rs1860404; rs363417; rs363232; rs363231; rs2255321; rs363228; rs363221; rs363263; rs4752045; rs7085251; rs363223; rs363397; rs2072362; rs10082463; rs363332; rs11817133; rs2803812; rs363413; rs363252; rs2283138; rs363400; rs363404; rs363405; rs363248; rs363334; rs363341; rs363225; rs363251; rs2283139; rs363279; rs363401; rs363247; rs3753127; rs363338; rs363396; rs363395; rs363222; rs363336; rs363277; rs363256; rs363390; rs363394; rs363398; rs363342; rs3026060; rs363333; rs363253; rs2244249; rs2072364; rs363389; rs929493; rs11568725; rs363269; rs363408; rs2283142; rs2532809; rs363393; rs363230; rs363343; rs363270; rs7095278; rs2803811; rs363335; rs12251984; rs2532805; rs2255062; rs363266; rs363220; rs363340; rs363246; rs363418; rs363260; rs7099216; rs2532808; rs7899301; rs363265; rs363391; rs17095973; rs363257; rs363420; rs2803815; rs363273; rs363245; rs2299615; rs363268; rs363249; rs11819661; rs2532807; rs363406; rs3026052; rs363407; rs11197936; rs7085415; rs2072363; rs2619093; rs363386; rs11816858; rs363250; rs363399; rs2283141; rs363229; rs2256299; rs363254; rs2240779; rs7100827; rs363264; rs363412; rs2283136; rs363419; rs363416; rs2532806; rs363409; rs11197932; rs11817105; rs2255063; rs363385; rs2283137; rs363281; rs2619095; rs12412905; rs11197931; rs3026051; rs1042543; rs2619094; rs35772469; rs35606571; rs3026065; rs2429507; rs363261; rs12217714; rs36022272; rs3026053; rs11197938; rs34299747; rs12358252; rs12359740; rs363384; rs12254490; rs363258; rs35868817; rs3026056; rs11197934; rs2270143; rs12354804; rs36039915; rs2532810; rs12359442; rs34784034; rs35866947; rs3026061; rs363392; rs3026070; rs11369697; rs35000397; rs363402; rs3026057; rs363244; rs363410; rs34975750; rs3026062; rs3026069; rs36079170; rs12781403; rs17096012; rs3026068; rs35114321; rs35533634; rs363255; rs3026058; rs34291858; rs34672616; rs36083737; rs7088569; rs3026064; rs3026067; rs11313765; rs41284384; rs35784393; rs11197933; rs2254950; rs34235015; rs35317678; rs34855821; rs363414; rs3026063; rs11433861; rs363339; rs3026055; rs2803813; rs3026066; rs12263683; rs7894469; rs36080619; rs35584666; rs17543336; rs363259; rs363267; rs4751619; rs363415; rs36075729; rs3026054; rs2429506; rs917584; rs11197935; rs12217705; rs12412553; rs7898581; rs34318947; rs2532804; rs2532803; rs2283135; rs10424; rs10886050; rs10886051; rs11197939; rs11197940; rs11568718; rs11568719; rs11568720; rs11568722; rs12266296; rs12337; rs2532801; rs2619097; rs2848; rs3026049; rs3026050; rs34094598; rs34323464; rs35664484; rs363235; rs363236; rs363238; rs363241; rs363242; rs363282; rs363283; rs363284; rs363285; rs363286; rs363287; rs363288; rs363290; rs363291; rs363292; rs363293; rs363294; rs363295; rs363296; rs363297; rs363298; rs363327; rs363328; rs363329; rs363330; rs363373; rs363374; rs363375; rs363376; rs363377; rs363378; rs363379; rs363380; rs363381; rs363383

# Macromolecular_Interacting_Partner_9_General_References:
8095030; 8245983; 7905859; 11443533; 12009896

# Macromolecular_Interacting_Partner_9_References:
15680169; 15684695; 15836622; 16081470

# Macromolecular_Interacting_Partner_10_ID:
7884

# Macromolecular_Interacting_Partner_10_Name:
Large neutral amino acids transporter small subunit 2

# Macromolecular_Interacting_Partner_10_Synonyms:
L-type amino acid transporter 2; hLAT2

# Macromolecular_Interacting_Partner_10_Gene_Name:
SLC7A8

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Large neutral amino acids transporter small subunit 2
MEEGARHRNNTEKKHPGGGESDASPEAGSGGGGVALKKEIGLVSACGIIVGNIIGSGIFV
SPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGF
LRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSV
RWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQ
GSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASN
AVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVK
RCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPI
KINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFI
ELLTLVSQKMCVVVYPEVERGSGTEEANEDMEEQQQPMYQPTPTKDKDVAGQPQP

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
535

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
58382

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
5.75

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  amino acid permease activity
Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_10_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_10_Specific_Function:
Sodium-independent, high-affinity transport of large neutral amino acids. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_10_Signals:
None

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
40-60
72-92
113-133
155-175
189-209
231-251
268-288
310-330
362-382
388-408
424-444
447-467

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
6642960

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
LAT2_HUMAN (Q9UHI5)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
SLC7A8

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
SLC7A8

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:11066

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Membrane; multi-pass membrane protein (Probable)

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>1608 bp
ATGGAAGAAGGAGCCAGGCACCGAAACAACACCGAAAAGAAACACCCAGGTGGGGGCGAG
TCGGACGCCAGCCCCGAGGCTGGTTCCGGAGGGGGCGGAGTAGCCCTGAAGAAAGAGATC
GGATTGGTCAGTGCCTGTGGTATCATCGTAGGGAACATCATCGGCTCTGGAATCTTTGTC
TCGCCAAAGGGAGTGCTGGAGAATGCTGGTTCTGTGGGCCTTGCTCTCATCGTCTGGATT
GTGACGGGCTTCATCACAGTTGTGGGAGCCCTCTGCTATGCTGAACTCGGGGTCACCATC
CCCAAATCTGGAGGTGACTACTCCTATGTCAAGGACATCTTCGGAGGACTGGCTGGGTTC
CTGAGGCTGTGGATTGCTGTGCTGGTGATCTACCCCACCAACCAGGCTGTCATCGCCCTC
ACCTTCTCCAACTACGTGCTGCAGCCGCTCTTCCCCACCTGCTTCCCCCCAGAGTCTGGC
CTTCGGCTCCTGGCTGCCATCTGCTTATTGCTCCTCACATGGGTCAACTGTTCCAGTGTG
CGGTGGGCCACCCGGGTTCAAGACATCTTCACAGCTGGGAAGCTCCTGGCCTTGGCCCTG
ATTATCATCATGGGGATTGTACAGATATGCAAAGGAGAGTACTTCTGGCTGGAGCCAAAG
AATGCATTTGAGAATTTCCAGGAACCTGACATCGGCCTCGTCGCACTGGCTTTCCTTCAG
GGCTCCTTTGCCTATGGAGGCTGGAACTTTCTGAATTACGTGACTGAGGAGCTTGTTGAT
CCCTACAAGAACCTTCCCAGAGCCATCTTCATCTCCATCCCACTGGTCACATTTGTGTAT
GTCTTTGCCAATGTCGCTTATGTCACTGCAATGTCCCCCCAGGAGCTGCTGGCATCCAAC
GCCGTCGCTGTGACTTTTGGAGAGAAGCTCCTAGGAGTCATGGCCTGGATCATGCCCATT
TCTGTTGCCCTGTCCACATTTGGAGGAGTTAATGGGTCTCTCTTCACCTCCTCTCGGCTG
TTCTTCGCTGGAGCCCGAGAGGGCCACCTTCCCAGTGTGTTGGCCATGATCCACGTGAAG
CGCTGCACCCCAATCCCAGCCCTGCTCTTCACATGCATCTCCACCCTGCTGATGCTGGTC
ACCAGCGACATGTACACACTCATCAACTACGTGGGCTTCATCAACTACCTCTTCTATGGG
GTCACGGTTGCTGGACAGATAGTCCTTCGCTGGAAGAAGCCTGATATCCCCCGCCCCATC
AAGATCAACCTGCTGTTCCCCATCATCTACTTGCTGTTCTGGGCCTTCCTGCTGGTCTTC
AGCCTGTGGTCAGAGCCGGTGGTGTGTGGCATTGGCCTGGCCATCATGCTGACAGGAGTG
CCTGTCTATTTCCTGGGTGTTTACTGGCAACACAAGCCCAAGTGTTTCAGTGACTTCATT
GAGCTGCTAACCCTGGTGAGCCAGAAGATGTGTGTGGTCGTGTACCCCGAGGTGGAGCGG
GGCTCAGGGACAGAGGAGGCTAATGAGGACATGGAGGAGCAGCAGCAGCCCATGTACCAA
CCCACTCCCACGAAGGACAAGGACGTGGCGGGGCAGCCCCAGCCCTGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
AF171669

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_10_Locus:
14q11.2

# Macromolecular_Interacting_Partner_10_SNPs:
rs1884545; rs7157021; rs17183863; rs2236135; rs2268878; rs927041; rs2331937; rs2273394; rs761874; rs761873; rs7140404; rs12879346; rs2877534; rs6572998; rs4982733; rs12588118; rs7152605; rs8011999; rs10137531; rs12881021; rs17794274; rs10136041; rs8007275; rs1045863; rs8008980; rs12433421; rs10138112; rs17198995; rs1015089; rs7151708; rs10150355; rs2239627; rs6572981; rs910795; rs2236133; rs8010887; rs6572982; rs1569951; rs3783436; rs1998055; rs6572983; rs2239629; rs7157207; rs2268873; rs8013529; rs1983698; rs4982736; rs2013931; rs11845990; rs6573011; rs4982737; rs2268875; rs7145842; rs8010718; rs2239628; rs2268877; rs10146960; rs10132060; rs17127069; rs10145863; rs11625112; rs4982735; rs7143368; rs10132368; rs2180395; rs7150157; rs2268876; rs10151002; rs2180397; rs2073305; rs2268872; rs4982732; rs10143650; rs17127010; rs10151823; rs7145789; rs999165; rs4982738; rs7142162; rs10143908; rs8018941; rs6572985; rs17127067; rs10146083; rs8011016; rs17256099; rs12894506; rs12881648; rs7151578; rs10150592; rs12436035; rs10138784; rs17127071; rs8023105; rs17127381; rs17127407; rs7141505; rs10873088; rs6573018; rs17183905; rs7156771; rs8014783; rs17794251; rs1569952; rs17126827; rs1062956; rs35426759; rs35143650; rs35529368; rs34044964; rs17127150; rs34617302; rs35771926; rs3830906; rs1045856; rs34025022; rs35277613; rs34346623; rs10137792; rs36051706; rs34068650; rs10622298; rs34455971; rs13102; rs33965973; rs10151212; rs4426260; rs28412256; rs35887043; rs28452404; rs12050365; rs35285425; rs34297545; rs34282834; rs34620975; rs8014757; rs35295501; rs5807207; rs34986192; rs28715334; rs35321429; rs34647056; rs17794280; rs28716277; rs3045526; rs34382575; rs3216637; rs33973055; rs35231818; rs7141211; rs28380081; rs5807210; rs10577714; rs35235753; rs8006408; rs1950640; rs34404210; rs35329117; rs2006065; rs33941217; rs8017084; rs2268874; rs8014900; rs28468418; rs28479223; rs5807209; rs34651620; rs7157193; rs5807206; rs28420906; rs28564841; rs34812438; rs35113644; rs12889021; rs10139545; rs34407994; rs28720057; rs2236134; rs34189473; rs34355692; rs12887179; rs35839488; rs10139157; rs35633387; rs34288927; rs33938109; rs4981459; rs35513137; rs3831862; rs33925152; rs11421724; rs8010982; rs35691569; rs35164856; rs35700544; rs28387059; rs11405198; rs35038963; rs12897350; rs8011360; rs28544495; rs28712199; rs761876; rs10633003; rs8007040; rs35093985; rs28459366; rs33991941; rs35242233; rs10138496; rs12884294; rs12878384; rs35679158; rs28616796; rs1985576; rs34916893; rs34473235; rs35639414; rs34469419; rs5807211; rs12887877; rs34636766; rs34904410; rs10650339; rs28508452; rs9743483; rs12893730; rs34222784; rs12435884; rs34550296; rs28479481; rs1569953; rs12879493; rs34974601; rs36088546; rs11274176; rs12879505; rs12879494; rs8010847; rs10438126; rs12879509; rs34691153; rs11850262; rs12434881; rs12435730; rs12889213; rs1474920; rs17127493; rs17256058; rs17256106; rs1884543; rs1884544; rs2144827; rs2239630; rs2239631; rs2239632; rs2239633; rs2239634; rs2239635; rs2239636; rs2285023; rs2331938; rs2331939; rs3759608; rs4981458; rs4982731; rs4982739; rs7151703; rs7155790; rs7158521; rs729531; rs761875; rs8015478

# Macromolecular_Interacting_Partner_10_General_References:
10574970; 10080183; 10391915

# Macromolecular_Interacting_Partner_10_References:
15180924; 15200428; 15271688; 15466357

# Macromolecular_Interacting_Partner_11_ID:
8846

# Macromolecular_Interacting_Partner_11_Name:
OTTHUMP00000017019

# Macromolecular_Interacting_Partner_11_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_11_Gene_Name:
SLC16A10

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>
OTTHUMP00000017019WVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLM
SSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILL
PLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRKKFS
PPKKIFNFAIFKVTAYAVWAVGIPLALFGYFVPYVHLAKFSFVILKYE

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
210

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
23037

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
9.91

# Macromolecular_Interacting_Partner_11_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_11_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_11_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF07690:MFS_1

# Macromolecular_Interacting_Partner_11_Signals:
1-21

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
5-24; 31-50; 55-77; 84-106; 116-136; 175-197

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
55664353

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
Q5VWW7_HUMAN (Q5VWW7)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
SLC16A10

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
SLC16A10

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:17027

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>1548 bp
ATGGTGCTCTCCCAGGAGGAGCCGGACTCCGCGCGGGGCACGAGCGAGGCGCAGCCGCTC
GGCCCCGCGCCCACGGGGGCCGCTCCGCCGCCCGGCCCGGGACCCTCGGACAGCCCCGAG
GCGGCTGTCGAGAAGGTGGAGGTGGAGCTGGCGGGGCCGGCGACCGCGGAGCCCCATGAG
CCCCCCGAACCCCCCGAGGGCGGCTGGGGCTGGCTGGTGATGCTGGCGGCCATGTGGTGC
AACGGGTCGGTGTTCGGCATCCAGAACGCTTGCGGGGTGCTCTTCGTGTCCATGCTGGAA
ACCTTCGGCTCCAAAGACGATGACAAGATGGTCTTTAAGACAGCATGGGTAGGTTCTCTC
TCCATGGGGATGATTTTCTTTTGCTGCCCAATAGTCAGCGTCTTCACAGACCTATTTGGT
TGTCGGAAAACAGCTGTCGTGGGTGCTGCTGTTGGATTTGTTGGGCTCATGTCCAGTTCT
TTTGTAAGTTCCATCGAGCCTCTGTACCTTACCTATGGAATCATATTTGCCTGCGGCTGC
TCCTTTGCATACCAGCCTTCATTGGTCATTTTGGGACACTATTTCAAGAAGCGCCTTGGA
CTGGTGAATGGCATTGTCACTGCTGGCAGCAGTGTCTTCACAATCCTGCTGCCTTTGCTC
TTAAGGGTTCTGATTGACAGCGTGGGCCTCTTTTACACATTGAGGGTGCTCTGCATCTTC
ATGTTTGTTCTCTTTCTGGCTGGCTTTACTTACCGACCTCTTGCTACCAGTACCAAAGAT
AAAGAGAGTGGAGGTAGCGGATCCTCCCTCTTTTCCAGGAAAAAGTTCAGTCCTCCAAAA
AAAATTTTCAATTTTGCCATCTTCAAGGTGACAGCTTATGCAGTGTGGGCAGTTGGAATA
CCACTTGCACTTTTTGGATACTTTGTGCCTTATGTTCACTTGATGAAACATGTAAATGAA
AGATTTCAAGATGAAAAAAATAAAGAGGTTGTTCTCATGTGCATTGGCGTCACTTCAGGA
GTTGGACGACTGCTCTTTGGCCGGATTGCAGATTATGTGCCTGGTGTGAAGAAGGTTTAT
CTACAGGTACTCTCCTTTTTCTTCATTGGTCTGATGTCCATGATGATTCCTCTGTGTAGC
ATCTTTGGGGCCCTCATTGCTGTGTGCCTCATCATGGGTCTCTTCGATGGATGCTTCATT
TCCATTATGGCTCCCATAGCCTTTGAGTTAGTTGGTGCCCAGGATGTCTCCCAAGCAATT
GGATTTCTGCTCGGATTCATGTCTATACCCATGACTGTTGGCCCACCCATTGCAGGGTTA
CTTCGTGACAAACTGGGCTCCTATGATGTGGCATTCTACCTCGCTGGAGTCCCTCCCCTT
ATTGGAGGTGCTGTGCTTTGTTTTATCCCGTGGATCCATAGTAAGAAGCAAAGAGAGATC
AGTAAAACCACTGGAAAAGAAAAGATGGAGAAAATGTTGGAAAACCAGAACTCTCTGCTG
TCAAGTTCATCTGGAATGTTCAAGAAAGAATCTGACTCTATTATTTAA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
AL360227

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_11_Locus:
6q21-q22

# Macromolecular_Interacting_Partner_11_SNPs:
Not Available

# Macromolecular_Interacting_Partner_11_General_References:
Not Available

# Macromolecular_Interacting_Partner_11_References:
Not Available

End of HMDB00181

Beginning of HMDB00182
# Accession_No:
HMDB00182

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-19 11:37:53

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
L-Lysine

# Description:
L-lysine is an essential amino acid. Normal requirements for lysine have been found to be about 8 g per day or 12 mg/kg in adults. Children and infants need more- 44 mg/kg per day for an eleven to-twelve-year old, and 97 mg/kg per day for three-to six-month old. Lysine is highly concentrated in muscle compared to most other amino acids. Lysine is high in foods such as wheat germ, cottage cheese and chicken. Of meat products, wild game and pork have the highest concentration of lysine. Fruits and vegetables contain little lysine, except avocados. Normal lysine metabolism is dependent upon many nutrients including niacin, vitamin B6, riboflavin, vitamin C, glutamic acid and iron. Excess arginine antagonizes lysine. Several inborn errors of lysine metabolism are known. Most are marked by mental retardation with occasional diverse symptoms such as absence of secondary sex characteristics, undescended testes, abnormal facial structure, anemia, obesity, enlarged liver and spleen, and eye muscle imbalance. Lysine also may be a useful adjunct in the treatment of osteoporosis. Although high protein diets result in loss of large amounts of calcium in urine, so does lysine deficiency. Lysine may be an adjunct therapy because it reduces calcium losses in urine. Lysine deficiency also may result in immunodeficiency. Requirements for this amino acid are probably increased by stress. Lysine toxicity has not occurred with oral doses in humans. Lysine dosages are presently too small and may fail to reach the concentrations necessary to prove potential therapeutic applications. Lysine metabolites, amino caproic acid and carnitine have already shown their therapeutic potential. Thirty grams daily of amino caproic acid has been used as an initial daily dose in treating blood clotting disorders, indicating that the proper doses of lysine, its precursor, have yet to be used in medicine. Low lysine levels have been found in patients with Parkinson's, hypothyroidism, kidney disease, asthma and depression. The exact significance of these levels is unclear, yet lysine therapy can normalize the level and has been associated with improvement of some patients with these conditions. Abnormally elevated hydroxylysines have been found in virtually all chronic degenerative diseases and coumadin therapy. The levels of this stress marker may be improved by high doses of vitamin C. Lysine is particularly useful in therapy for marasmus (wasting) and herpes simplex. It stops the growth of herpes simplex in culture, and has helped to reduce the number and occurrence of cold sores in clinical studies. Dosing has not been adequately studied, but beneficial clinical effects occur in doses ranging from 100 mg to 4 g a day. Higher doses may also be useful, and toxicity has not been reported in doses as high as 8 g per day. Diets high in lysine and low in arginine can be useful in the prevention and treatment of herpes. Some researchers think herpes simplex virus is involved in many other diseases related to cranial nerves such as migraines, Bell's palsy and Meniere's disease. Herpes blister fluid will produce fatal encephalitis in the rabbit. (http://www.dcnutrition.com)

# Synonyms:
(+)-S-Lysine; (S)-2,6-Diaminohexanoate; (S)-2,6-Diaminohexanoic acid; (S)-2,6-diamino-Hexanoate; (S)-2,6-diamino-Hexanoic acid; (S)-Lysine; (S)-a,e-Diaminocaproate; (S)-a,e-Diaminocaproic acid; 2,6-Diaminohexanoate; 2,6-Diaminohexanoic acid; 6-amino-Aminutrin; 6-amino-L-Norleucine; Aminutrin; L-(+)-Lysine; L-2,6-Diainohexanoate; L-2,6-Diainohexanoic acid; L-2,6-Diaminocaproate; L-2,6-Diaminocaproic acid; L-Lys; Lys; Lysine; Lysine acid; a-Lysine; h-Lys-oh; alpha-Lysine

# Chemical_IUPAC_Name:
2,6-diaminohexanoic acid

# Chemical_Formula:
C6H14N2O2

# Chemical_Structure:
tbl_chemical:::HMDB00182_ZOOM.png:::119283238086015869

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00182_THUMB.png:::119283237929466

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid; alpha-aminoacid

# Taxonomy_Biofunction:
Essential amino acids; Component of Aminoacyl-tRNA biosynthesis; Component of Lysine biosynthesis

# Taxonomy_Source:
Exogenous

# Molecular_Weight:
146.10553

# Molecular_Weight_Avg:
146.18756

# Smiles_String_isomeric:
NCCCC[C@H](N)C(O)=O

# Smiles_String_canonical:
NCCCCC(N)C(O)=O

# KEGG_Compound_ID:
C00047

# BioCyc_ID:
LYS

# PubChem_CID:
5962

# PubChem_SID:
819792; 824513; 7849363; 3152007; 837797; 11532258; 11532840; 744162; 833113; 148795; 763016; 854742; 3349; 711036; 824970; 824263; 10527684; 7854303; 829089; 6436589; 174718; 821190; 837782; 837799; 8153705; 836276; 8144553

# OMIM_ID:
238700; 238710; 238750; 247950

# Metagene_ID:
Not Available

# BiGG_ID:
33655

# Wikipedia_ID:
L-Lysine

# METLIN_ID:
5200

# Ref_ID:
11072949; 15911239; 12297216; 14992292; 12097436; 7523469; 10330678; 6696735; 12834252; 12636162; 6198473

# ChEBI_ID:
18019

# CAS_Registry_Number:
56-87-1

# InChI:
InChI=1/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/t5-/m0/s1

# Synthesis_Reference:
DL-Lysine-6-C14 and DL-a-aminoadipic acid-6-C14.     Rothstein, Morton.    Univ. of California School of Med.,  San Francisco,    Biochemical Preparations  (1961),  8  85-8.

# Melting_Point:
224.5 oC

# Melting_Point_predicted:
31.7 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1000.0 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
105.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
1

# State:
Solid

# LogP:
-3.05 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-3.75 [Predicted by ALOGPS]; -2.9 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::L-Lysine monohydrochloride.pdf:::1132562212486563707

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::L-Lysine.mol:::1132723812468538695

# SDF_File_[Text]:
tbl_chemical:::HMDB00182.sdf:::119283237615741586

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00182.pdb:::119283237793986661

# PDB_ID:
1BBU

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::050106_P00_02_IS_1DP_presat.png:::11509226991185574

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::050106_P00_02_IS_1DP_presat_1.zip:::114787914777372174

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::050106_P00_02_IS_1DP_Assigned.png:::116552568389365829

# C_NMR_Spectra:
tbl_cnmr:::050106_P00_02_IS_1DC_70.jpg:::114168392396620949

# C_NMR_FIDS_Spectra:
tbl_cnmr:::050106_P00_02_IS_1DC_70.zip:::114168392392622984

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::050106_P00_02_IS_1DC_70_Assigned.jpg:::115998582983548901

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050106_P00_02_IS_2DHSQC_234.jpg:::114608717451142497

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050106_P00_02_IS_2DHSQC_234.zip:::114608717453553511

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050106_P00_02_IS_2DHSQC_234_Assigned.jpg:::117803899416212704

# Predicted_H_NMR_Spectrum:
tbl_chemical:::L-Lysine.gif:::1132732119265819476

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00182_peaks.txt:::1156309601124715515

# Predicted_C_NMR_Spectrum:
tbl_chemical:::L-Lysine_C.gif:::1132737713908993947

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00182_peaks.txt:::1156310790470649369

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00182L.png:::117555263496397316; Medium Energy:tbl_ms:::HMDB00182M.png:::117555268813820918; High Energy:tbl_ms:::HMDB00182H.png:::117555272006528386

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000043.png:::116890824154630093

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000043.txt:::116890824154623956

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000043.png:::116890824112567752

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000043.txt:::11689082415461726

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria; nucleus; peroxisome

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Urine	10.9(2.105-19.7)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Blood	190.0 +/- 60.0	umol/L	Newborn:0-30_days_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	164.0 +/- 28.0	umol/L	Children:1-13_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	198.0 +/- 31.0	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	183.0 +/- 34.0	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	188.0 (156.0-220.0)	umol/L	Adult:>18_yrs_old	Both	Normal	12297216
Cerebrospinal_Fluid(CSF)	21.7 +/- 3.7	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	87.0 +/- 39.0	uM	Adult:>18_yrs_old	Both	Normal	HMP Experimental
Cerebrospinal_Fluid(CSF)	27.7 +/- 8.0	umol/L	Adult:>18_yrs_old	N/A	Normal	15911239
Cerebrospinal_Fluid(CSF)	31.5 +/- 5.7	umol/L	Adult:>18_yrs_old	N/A	Normal	6198473
Cerebrospinal_Fluid(CSF)	25.7 +/- 5.3	umol/L	Adult:>18_yrs_old	N/A	Normal	6198473
Cerebrospinal_Fluid(CSF)	23.9 (18.1-29.7)	umol/L	Adult:>18_yrs_old	Both	Normal	12834252
Saliva	>10	umol/L	Adult:>18_yrs_old	Both	Normal	12097436


# Concentration_[Abnormal]:
Blood	140.0	umol/L	Adult:>18_yrs_old	Both	Diabetes	6696735
Blood	128.0 (119.0-137.0)	umol/L	Adult:>18_yrs_old	Both	Refractory localization-related epilepsy (RLE)	14992292
Cerebrospinal_Fluid(CSF)	26.9 +/- 11.1	umol/L	N/A	N/A	leukemia	15911239
Cerebrospinal_Fluid(CSF)	21.9 +/- 6.2	umol/L	Adult:>18_yrs_old	N/A	leukemia with CNS disease	15911239


# Associated_Disorders:
Alzheimer's Disease; Decreased End-Stage Renal Disease (ESRD); Diabetes; End-stage Renal Disease (ESRD); Eosinophilia; Kidney Damage; leukemia; leukemia with CNS disease; Refractory Localization-Related Epilepsy (RLE); Rhinitis

# Pathway_Names:
Lysine degradation

# Pathway_Images:
Lysine_degradation.jpg

# KEGG_Images:
map00310

# Pathway_Graphs:
Lysine_degradation_Graph.jpg

# Pathway_SBMLs:
Lysine_degradation.xml

# Metabolic_Enzyme_1_ID:
6133

# Metabolic_Enzyme_1_Name:
Alpha-aminoadipic semialdehyde synthase, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
LKR/SDH[Includes: Lysine ketoglutarate reductase; LOR; LKR; Saccharopine dehydrogenase; SDH]

# Metabolic_Enzyme_1_Gene_Name:
AASS

# Metabolic_Enzyme_1_Protein_Sequence:
>Alphaaminoadipic semialdehyde synthase, mitochondrial precursor
MLQVHRTGLGRLGVSLSKGLHHKAVLAVRREDVNAWERRAPLAPKHIKGITNLGYKVLIQ
PSNRRAIHDKDYVKAGGILQEDISEACLILGVKRPPEEKLMSRKTYAFFSHTIKAQEANM
GLLDEILKQEIRLIDYEKMVDHRGVRVVAFGQWAGVAGMINILHGMGLRLLALGHHTPFM
HIGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQAIFNELPC
EYVEPHELKEVSQTGDLRKVYGTVLSRHHHLVRKTDAVYDPAEYDKHPERYISRFNTDIA
PYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKFSPAGVEGCPALPHKLVAICDISADTG
GSIEFMTECTTIEHPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIEATECFGDMLY
PYVEEMILSDATQPLESQNFSPVVRDAVITSNGTLPDKYKYIQTLRESRERAQSLSMGTR
RKVLVLGSGYISEPVLEYLSRDGNIEITVGSDMKNQIEQLGKKYNINPVSMDICKQEEKL
GFLVAKQDLVISLLPYVLHPLVAKACITNKVNMVTASYITPALKELEKSVEDAGITIIGE
LGLDPGLDHMLAMETIDKAKEVGATIESYISYCGGLPAPEHSNNPLRYKFSWSPVGVLMN
VMQSATYLLDGKVVNVAGGISFLDAVTSMDFFPGLNLEGYPNRDSTKYAEIYGISSAHTL
LRGTLRYKGYMKALNGFVKLGLINREALPAFRPEANPLTWKQLLCDLVGISPSSEHDVLK
EAVLKKLGGDNTQLEAAEWLGLLGDEQVPQAESILDALSKHLVMKLSYGPEEKDMIVMRD
SFGIRHPSGHLEHKTIDLVAYGDINGFSAMAKTVGLPTAMAAKMLLDGEIGAKGLMGPFS
KEIYGPILERIKAEGIIYTTQSTIKP

# Metabolic_Enzyme_1_Number_of_Residues:
926

# Metabolic_Enzyme_1_Molecular_Weight:
102133

# Metabolic_Enzyme_1_Theoretical_pI:
6.62

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively

# Metabolic_Enzyme_1_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_1_Reaction:
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01262:AlaDh_PNT_C;
PF05222:AlaDh_PNT_N;
PF03435:Saccharop_dh

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.5.1.8;EC 1.5.1.9

# Metabolic_Enzyme_1_GenBank_ID_Protein:
7264724

# Metabolic_Enzyme_1_SwissProt_ID:
AASS_HUMAN (Q9UDR5)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
AASS

# Metabolic_Enzyme_1_Geneatlas_id:
AASS

# Metabolic_Enzyme_1_hgnc_id:
HGNC:17366

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_1_Gene_Sequence:
>2781 bp
ATGCTGCAAGTACATAGGACTGGACTGGGCAGGCTGGGGGTCAGCCTCTCCAAGGGTCTT
CACCACAAAGCTGTGTTGGCCGTCCGGAGGGAGGATGTGAACGCCTGGGAGAGAAGGGCC
CCGCTAGCTCCCAAGCACATCAAAGGCATCACCAATCTGGGATACAAGGTCTTGATACAG
CCTTCGAATCGGCGGGCCATTCATGATAAGGACTATGTCAAAGCTGGTGGCATTCTTCAG
GAGGATATTTCTGAAGCTTGTCTAATTTTAGGAGTTAAAAGACCTCCAGAGGAAAAATTA
ATGTCCAGGAAGACTTATGCATTTTTCTCCCACACAATAAAAGCTCAGGAGGCCAATATG
GGCTTGTTGGATGAGATTCTAAAACAGGAAATTCGCCTTATTGATTATGAGAAAATGGTG
GATCATAGAGGAGTACGGGTAGTGGCATTTGGACAGTGGGCTGGTGTGGCAGGAATGATC
AACATTTTACATGGAATGGGTTTAAGGCTCCTTGCTTTGGGACATCACACACCTTTTATG
CACATTGGCATGGCTCATAACTACAGGAATAGCAGTCAGGCTGTGCAAGCTGTCCGTGAT
GCTGGCTATGAAATATCTTTGGGTTTGATGCCTAAGTCAATAGGACCCTTAACATTTGTG
TTCACAGGAACTGGTAATGTTTCTAAGGGAGCCCAAGCAATCTTTAATGAGCTACCTTGT
GAATATGTGGAGCCCCATGAATTAAAAGAAGTTTCCCAAACTGGAGACCTCAGAAAAGTG
TATGGGACGGTGTTAAGTCGTCATCATCATCTTGTCAGGAAAACAGATGCTGTGTATGAT
CCTGCAGAGTATGACAAACATCCGGAGCGCTACATAAGTCGTTTTAATACTGATATTGCA
CCCTATACAACTTGCTTAATTAATGGAATCTACTGGGAACAAAACACTCCTCGCCTCCTA
ACCCGCCAAGATGCTCAGAGTCTCCTGGCTCCGGGCAAGTTCTCACCTGCTGGTGTGGAA
GGCTGCCCTGCATTACCACACAAACTCGTGGCAATATGTGACATTTCAGCTGACACAGGA
GGGTCTATAGAGTTTATGACTGAGTGTACAACAATAGAGCATCCCTTTTGCATGTATGAT
GCAGACCAGCATATTATTCATGACAGTGTTGAAGGCTCGGGGATCCTGATGTGTTCCATT
GACAATTTGCCGGCACAGCTCCCAATTGAAGCTACAGAATGCTTTGGAGACATGCTTTAC
CCTTATGTTGAAGAAATGATATTATCAGACGCGACACAGCCTCTTGAAAGTCAGAATTTT
TCTCCTGTGGTGAGAGATGCAGTGATTACATCCAACGGTACATTACCTGATAAATATAAA
TATATCCAGACACTCCGGGAGAGCAGGGAACGTGCTCAGTCACTTTCAATGGGCACCAGG
AGAAAGGTTTTGGTTCTTGGATCTGGCTACATATCTGAGCCTGTATTAGAATATTTATCA
AGAGATGGCAATATAGAAATAACAGTAGGATCTGACATGAAGAATCAAATTGAACAGTTA
GGCAAGAAATATAATATTAATCCTGTTAGCATGGACATTTGTAAACAAGAAGAGAAGCTG
GGCTTCTTGGTGGCAAAACAGGATCTTGTCATCAGCTTGTTGCCTTATGTATTGCACCCT
CTTGTGGCCAAGGCCTGCATCACAAACAAAGTTAACATGGTCACTGCAAGCTACATCACA
CCAGCACTAAAAGAATTGGAAAAGAGTGTGGAAGATGCTGGCATCACAATCATTGGTGAA
TTGGGATTGGACCCTGGTCTGGATCACATGTTAGCAATGGAAACAATAGATAAAGCCAAG
GAAGTGGGAGCCACGATTGAATCATATATTTCCTACTGTGGTGGGCTTCCAGCCCCTGAA
CATTCAAACAATCCATTGAGATATAAATTTAGCTGGAGTCCAGTGGGAGTTTTGATGAAT
GTAATGCAGTCTGCCACCTATCTGCTCGATGGAAAGGTTGTGAATGTTGCAGGAGGCATC
TCCTTTCTTGATGCCGTTACGTCCATGGATTTTTTTCCAGGATTAAATTTGGAAGGCTAT
CCTAACAGAGACAGTACGAAATATGCTGAGATTTATGGCATTTCTTCTGCTCACACTTTG
TTGCGGGGGACACTGAGATATAAGGGATATATGAAAGCTTTGAATGGATTTGTAAAATTA
GGTCTTATAAACAGAGAAGCGCTTCCTGCCTTTAGACCTGAGGCCAACCCTCTCACCTGG
AAACAACTCCTCTGTGACCTAGTTGGGATTTCACCCTCCTCTGAGCATGATGTGTTGAAG
GAAGCTGTTCTTAAGAAACTAGGAGGAGACAATACCCAGTTGGAGGCTGCTGAATGGTTG
GGCTTACTTGGGGATGAACAAGTTCCTCAGGCAGAGTCCATTCTGGATGCCCTCTCCAAG
CATTTGGTCATGAAGCTTTCCTATGGTCCTGAAGAAAAAGATATGATTGTGATGAGAGAC
AGCTTTGGAATCAGACATCCTTCTGGACATTTAGAACATAAAACGATTGATCTTGTGGCT
TATGGGGACATCAATGGCTTTTCAGCCATGGCTAAAACCGTGGGGTTACCCACCGCCATG
GCAGCCAAAATGTTGCTTGATGGTGAAATTGGAGCCAAAGGCCTAATGGGGCCCTTTTCA
AAGGAGATCTATGGACCAATATTGGAGCGAATTAAAGCAGAAGGCATTATATATACTACA
CAGAGTACAATTAAACCATAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF229180

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_1_Locus:
7q31.3

# Metabolic_Enzyme_1_SNPs:
rs17144072; rs34901960; rs1206361; rs279700; rs279699; rs1206372; rs2016284; rs1725067; rs1860507; rs1875409; rs1206374; rs279665; rs279663; rs4140745; rs2268075; rs1206368; rs6968699; rs12669983; rs2302338; rs1206366; rs2840105; rs279673; rs279701; rs6466812; rs17144099; rs7787099; rs3213699; rs11761176; rs1206367; rs1206362; rs279669; rs279677; rs279674; rs279668; rs279667; rs2134059; rs11771234; rs1206371; rs1206369; rs279680; rs969549; rs279706; rs1206370; rs2268076; rs12671513; rs10236532; rs1725066; rs279666; rs279676; rs279671; rs2268074; rs12532071; rs1405236; rs1206373; rs279664; rs6954861; rs12706384; rs1206375; rs6967194; rs10429059; rs6947355; rs1206376; rs12113399; rs12539675; rs12539712; rs279678; rs279675; rs1405237; rs13223149; rs279707; rs2215359; rs10233433; rs2268077; rs279679; rs10488107; rs10242443; rs1206380; rs12217; rs10246405; rs10464523; rs35040361; rs34141526; rs1405235; rs279702; rs1060229; rs6952185; rs13244397; rs6962679; rs10230768; rs1638961; rs3069225; rs35554728; rs34474265; rs13232539; rs6948979; rs12530583; rs13241339; rs41281710; rs2191296; rs34361634; rs35606909; rs28764931; rs35504523; rs28867970; rs6975301; rs1526317; rs35879326; rs35726770; rs6944507; rs13236890; rs35084745; rs17144085; rs35291950; rs34978806; rs35318724; rs34956031; rs35432331; rs34360736; rs10246429; rs13241330; rs279705; rs3180765; rs13231643; rs34033806; rs7455978; rs3180764; rs34112213; rs34729256; rs11765420; rs3832518; rs17532418; rs3213701; rs279672; rs6968099; rs34469506; rs17144088; rs34960462; rs34641952; rs28405443; rs12155158; rs279670; rs12113314; rs34852879; rs36059311; rs35704579; rs35361108; rs41281707; rs3213700; rs5887069; rs17532544; rs35006538; rs13231638; rs1138795; rs1065593; rs33947582; rs3202823; rs11379836; rs17348794; rs35382381; rs1061742; rs1138793; rs1206377; rs1206378; rs12532318; rs12674287; rs13232727; rs2268072; rs2268073; rs2270884; rs2300199; rs2300201; rs279689; rs279704; rs4727938; rs758692; rs7800294

# Metabolic_Enzyme_1_General_References:
12853948

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5885

# Metabolic_Enzyme_2_Name:
Lysyl-tRNA synthetase

# Metabolic_Enzyme_2_Synonyms:
Lysine--tRNA ligase; LysRS

# Metabolic_Enzyme_2_Gene_Name:
KARS

# Metabolic_Enzyme_2_Protein_Sequence:
>LysyltRNA synthetase
MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTT
DNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH
LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD
IIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFV
RQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAP
ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSG
MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR
KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE
GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG
LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV

# Metabolic_Enzyme_2_Number_of_Residues:
597

# Metabolic_Enzyme_2_Molecular_Weight:
68049

# Metabolic_Enzyme_2_Theoretical_pI:
6.31

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  lysine-tRNA ligase activity
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  binding
Function:  nucleic acid binding
 ||
>>>
Process:  lysyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_2_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_2_Specific_Function:
ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)

# Metabolic_Enzyme_2_Pathway:
map00300  Lysine biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_2_Reaction:
ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00152:tRNA-synt_2;
PF01336:tRNA_anti

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 6.1.1.6

# Metabolic_Enzyme_2_GenBank_ID_Protein:
505108

# Metabolic_Enzyme_2_SwissProt_ID:
SYK_HUMAN (Q15046)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
KARS

# Metabolic_Enzyme_2_Geneatlas_id:
KARS

# Metabolic_Enzyme_2_hgnc_id:
HGNC:6215

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1808 bp
GGCCCTCCGGGAAGATGGCGGCCGTGCAGGCGGCCGAGGTGAAAGTGGATGGCAGCGAGC
CGAAACTGAGCAAGAATGAGCTGAAGAGACGCCTGAAAGCTGAGAAGAAAGTAGCAGAGA
AGGAGGCCAAACAGAAAGAGCTCAGTGAGAAACAGCTAAGCCAAGCCACTGCTGCTGCCA
CCAACCACACCACTGATAATGGTGTGGGTCCTGAGGAAGAGAGCGTGGACCCAAATCAAT
ACTACAAAATCCGCAGTCAAGCAATTCATCAGCTGAAGGTCAATGGGGAAGACCCATACC
CACACAAGTTCCATGTAGACATCTCACTCACTGACTTCATCCAAAAATATAGTCACCTGC
AGCCTGGGGATCACCTGACTGACATCACCTTAAAGGTGGCAGGTAGGATCCATGCCAAAA
GAGCTTCTGGGGGAAAGCTCATCTTCTATGATCTTCGAGGAGAGGGGGTGAAGTTGCAAG
TCATGGCCAATTCCAGAAATTATAAATCAGAAGAAGAATTTATTCATATTAATAACAAAC
TGCGTCGGGGAGACATAATTGGAGTTCAGGGGAATCCTGGTAAAACCAAGAAGGGTGAGC
TGAGCATCATTCCGTATGAGATCACACTGCTGTCTCCCTGTTTGCATATGTTACCTCATC
TTCACTTTGGCCTCAAAGACAAGGAAACAAGGTATCGCCAGAGATACTTGGACTTGATCC
TGAATGACTTTGTGAGGCAGAAATTTATCATCCGCTCTAAGATCATCACATATATAAGAA
GTTTCTTAGATGAGCTGGGATTCCTAGAGATTGAAACTCCCATGATGAACATCATCCCAG
GGGGAGCCGTGGCCAAGCCTTTCATCACTTATCACAACGAGCTGGACATGAACTTATATA
TGAGAATTGCTCCAGAACTCTATCATAAGATGCTTGTGGTTGGTGGCATCGACCGGGTTT
ATGAAATTGGACGCCAGTTCCGGAATGAGGGGATTGATTTGACGCACAATCCTGAGTTCA
CCACCTGTGAGTTCTACATGGCCTATGCAGACTATCACGATCTCATGGAAATCACGGAGA
AGATGGTTTCAGGGATGGTGAAGCATATTACAGGCAGTTACAAGGTCACCTACCACCCAG
ATGGCCCAGAGGGCCAAGCCTACGATGTTGACTTCACCCCACCCTTCCGGCGAATCAACA
TGGTAGAAGAGCTTGAGAAAGCCCTGGGGATGAAGCTGCCAGAAACGAACCTCTTTGAAA
CTGAAGAAACTCGCAAAATTCTTGATGATATCTGTGTGGCAAAAGCTGTTGAATGCCCTC
CACCTCGGACCACAGCCAGGCTCCTTGACAAGCTTGTTGGGGAGTTCCTGGAAGTGACTT
GCATCAATCCTACATTCATCTGTGATCACCCACAGATAATGAGCCCTTTGGCTAAATGGC
ACCGCTCTAAAGAGGGTCTGACTGAGCGCTTTGAGCTGTTTGTCATGAAGAAAGAGATAT
GCAATGCGTATACTGAGCTGAATGATCCCATGCGGCAGCGGCAGCTTTTTGAAGAACAGG
CCAAGGCCAAGGCTGCAGGTGATGATGAGGCCATGTTCATAGATGAAAACTTCTGTACTG
CCCTGGAATATGGGCTGCCCCCCACAGCTGGCTGGGGCATGGGCATTGATCGAGTCGCCA
TGTTTCTCACGGACTCCAACAACATCAAGGAAGTACTTCTGTTTCCTGCCATGAAACCCG
AAGACAAGAAGGAGAATGTAGCAACCACTGATACACTGGAAAGCACAACAGTTGGCAGTT
CTGTCTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
D31890

# Metabolic_Enzyme_2_Chromosome_Location:
Not Available

# Metabolic_Enzyme_2_Locus:
Not Available

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
7584044; 9278442

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5817

# Metabolic_Enzyme_3_Name:
Biotinidase precursor

# Metabolic_Enzyme_3_Synonyms:
Not Available

# Metabolic_Enzyme_3_Gene_Name:
BTD

# Metabolic_Enzyme_3_Protein_Sequence:
>Biotinidase precursor
MSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVAAVYEHPSILSLNPLALISRQ
EALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPQVVRW
NPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCHSSDPRCPKDGRYQFNTNVVF
SNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRFGIFTCFDILFFDPAIRVLRD
YKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAANVHHPVLGMTGSGIHTPLESF
WYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSKFLKILSGDPYCEKDAQEVHC
DEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSNGLCCYLLYERPTLSKELYAL
GVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATGIFEFHLWGNFSTSYIFPLFL
TSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLYERD

# Metabolic_Enzyme_3_Number_of_Residues:
523

# Metabolic_Enzyme_3_Molecular_Weight:
58914

# Metabolic_Enzyme_3_Theoretical_pI:
5.72

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  nitrogen compound metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation

# Metabolic_Enzyme_3_Pathway:
map00780  Biotin metabolism

# Metabolic_Enzyme_3_Reaction:
biotin amide + H2O = biotin + NH3

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00795:CN_hydrolase

# Metabolic_Enzyme_3_Signals:
1-21

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.5.1.12

# Metabolic_Enzyme_3_GenBank_ID_Protein:
468824

# Metabolic_Enzyme_3_SwissProt_ID:
BTD_HUMAN (P43251)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
BTD

# Metabolic_Enzyme_3_Geneatlas_id:
BTD

# Metabolic_Enzyme_3_hgnc_id:
HGNC:1122

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_3_Gene_Sequence:
>1632 bp
ATGGCGCATGCGCATATTCAGGGCGGAAGGCGCGCTAAGAGCAGATTTGTGGTCTGCATT
ATGTCTGGAGCCAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTG
GGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGAGGCTGAATATTATGTGGCT
GCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAA
GAGGCCTTGGAGCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCA
GCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGGCATTCATGGATTCAACTTT
ACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGG
AACCCATGCCTGGAGCCTCACCGCTTCAATGACACAGAGGTGCTCCAGCGCCTGAGTTGT
ATGGCCATCAGGGGAGATATGTTCTTGGTGGCCAATCTTGGGACAAAGGAGCCTTGTCAT
AGCAGTGACCCAAGGTGCCCAAAAGATGGGAGATACCAGTTCAACACAAATGTCGTGTTC
AGCAATAATGGAACCCTTGTTGACCGCTACCGTAAACACAACCTCTACTTTGAGGCAGCA
TTCGATGTTCCTCTTAAAGTGGATCTCATCACCTTTGATACCCCCTTTGCTGGCAGGTTT
GGCATCTTCACATGCTTTGATATATTGTTCTTTGACCCTGCCATCAGAGTCCTCAGAGAC
TACAAGGTGAAGCATGTTGTGTACCCAACTGCCTGGATGAACCAGCTCCCACTCTTGGCA
GCAATTGAGATTCAGAAAGCTTTTGCTGTTGCCTTTGGCATCAACGTTCTGGCAGCTAAT
GTCCACCACCCAGTTCTGGGGATGACAGGAAGTGGCATACACACCCCTCTGGAGTCCTTT
TGGTACCATGACATGGAAAATCCCAAAAGTCACCTTATAATTGCCCAGGTGGCCAAAAAT
CCAGTGGGTCTCATTGGTGCAGAGAATGCAACAGGTGAAACGGACCCATCCCATAGTAAG
TTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCACTGT
GATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTAT
GACAATTTCACCCTGGTCCCTGTCTGGGGAAAGGAAGGCTATCTCCACGTCTGTTCCAAT
GGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCCCTG
GGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTG
GTCAGGTGTGGGGGTCTTGGCTTCGACACCTGCGGACAGGAAATCACAGAGGCCACGGGG
ATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTTCTG
ACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTC
CTGAGGAAAAGTAGGCTGTCCTCTGGGCTGGTGACGGCGGCTCTCTATGGGCGCTTGTAT
GAGAGGGACTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U03274

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_3_Locus:
3p25

# Metabolic_Enzyme_3_SNPs:
rs35034250; rs13078881; rs3817641; rs924814; rs2471809; rs2455826; rs4094397; rs2455820; rs9853116; rs2455810; rs1021849; rs2455916; rs9880034; rs4478067; rs2280770; rs13320591; rs760066; rs2471807; rs11128749; rs7651039; rs6773682; rs2455827; rs2470526; rs12489825; rs2455823; rs2470529; rs2455915; rs10510441; rs13319547; rs741747; rs741748; rs9858977; rs9310480; rs9866477; rs1296433; rs2734308; rs9858784; rs7640807; rs34356435; rs9310481; rs9849809; rs10212184; rs12330387; rs7621332; rs4626087; rs9827673; rs4309707; rs9825546; rs2455828; rs9310479; rs9830528; rs17041367; rs2470551; rs12639040; rs6807875; rs9836533; rs2174267; rs28934601; rs35976361; rs13073139; rs34885143; rs35145938; rs28475858; rs28612795; rs2055564; rs9838247; rs13066152; rs12494340; rs11714810; rs34101231; rs34976221; rs11916854; rs2471806; rs4298027; rs2470528; rs2455918; rs6803821; rs12493340; rs35141065; rs35452512; rs2470541; rs2654647; rs12631444; rs2455825; rs13068169; rs9873582; rs13075998; rs35719864; rs4685254; rs2734309; rs35863533; rs35004427; rs10621505; rs28576968; rs36065590; rs11915606; rs12330789; rs4407396; rs11717801; rs13088542; rs9755; rs35369543; rs7620644; rs9825684; rs4582034; rs35742912; rs28450862; rs28758269; rs34826323; rs7429324; rs2470527; rs13099874; rs35741795; rs34655059; rs9867921; rs36018115; rs2455822; rs2455824; rs28374257; rs6800368; rs1504098; rs1875798; rs2455917; rs9882597; rs11369757; rs11405819; rs6773959; rs35402548; rs9838246; rs34597886; rs36078683; rs35244780; rs2455821; rs35735277; rs9847991; rs9840496; rs34143777; rs34795748; rs2280771; rs12488812; rs34408221; rs28553993; rs9868928; rs9870498; rs35638740; rs13061544; rs34718841; rs35175965; rs2470525; rs4684257; rs36053401; rs11918810; rs12490588; rs13076664; rs13076834; rs13076843; rs13099347; rs1504099; rs2004783; rs2014933; rs2019160; rs2089054; rs2134784; rs2279841; rs2455852; rs2455853; rs2455854; rs2470530; rs2470531; rs2470532; rs2734307; rs3732720; rs3796302; rs3796305; rs6773994; rs6784844; rs6804782; rs7626148; rs869569; rs905555; rs9647358; rs9830541; rs9834785; rs9879788

# Metabolic_Enzyme_3_General_References:
7509806; 9530634; 9099842; 9654207

# Metabolic_Enzyme_3_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8531

# Macromolecular_Interacting_Partner_1_Name:
Low-affinity cationic amino acid transporter 2

# Macromolecular_Interacting_Partner_1_Synonyms:
CAT-2; CAT2

# Macromolecular_Interacting_Partner_1_Gene_Name:
SLC7A2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Lowaffinity cationic amino acid transporter 2
MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA
KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI
LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLL
SFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENG
TSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCF
MAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPM
PRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLM
AYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLF
CPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAI
VLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFS
YGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
658

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
71674

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.31

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
 Function:  amino acid permease activity
Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
 Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_1_Specific_Function:
Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine)

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_1_Signals:
1-543

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
38-59
64-84
105-125
164-184
193-213
249-269
290-309
340-360
387-407
411-431
491-511
525-549
558-578
583-603

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
849051

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
CTR2_HUMAN (P52569)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
SLC7A2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
SLC7A2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:11060

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1977 bp
ATGATTCCTTGCAGAGCCGCGCTGACCTTTGCCCGATGTCTGATCCGGAGAAAAATCGTG
ACCCTGGACAGTCTAGAAGACACCAAATTATGCCGCTGCTTATCCACCATGGACCTCATT
GCCCTGGGCGTTGGAAGCACCCTTGGGGCCGGGGTTTATGTCCTCGCTGGGGAGGTGGCC
AAGGCAGACTCGGGCCCCAGCATCGTGGTGTCCTTCCTCATTGCTGCCCTGGCTTCAGTG
ATGGCTGGCCTCTGCTATGCCGAATTTGGGGCCCGTGTTCCCAAGACGGGGTCTGCATAT
TTGTACACCTACGTGACTGTCGGAGAGCTGTGGGCCTTCATCACTGGCTGGAATCTCATT
TTATCGTATGTGATAGGTACATCAAGTGTTGCAAGAGCCGGGAGTGGCACCTTTGATGAA
CTTCTTAGCAAACAGATTGGTCAGTTTTTGAGGACATACTTCAGAATGAATTACACTGGT
CTTGCAGAATATCCCGATTTTTTTGCTGTGTGCCTTATATTACTTCTAGCAGGTCTTTTG
TCTTTTGGAGTAAAAGAGTCTGCTTGGGTGAATAAAGTCTTCACAGCTGTTAATATTCTC
GTCCTTCTGTTTGTGATGGTTGCTGGGTTTGTGAAAGGAAATGTGGCAAACTGGAAGATT
AGTGAAGAGTTTCTCAAAAATATATCAGCAAGTGCCAGAGAGCCACCTTCTGAAAACGGA
ACAAGTATCTATGGGGCTGGTGGCTTTATGCCTTATGGCTTTACGGGAACGTTGGCTGGT
GCTGCAACTTGCTTTTATGCCTTTGTGGGATTTGACTGCATTGCAACAACTGGTGAAGAA
GTTCGGAATCCCCAGAAAGCTATTCCCATTGGAATTGTGACGTCTTTGCTTGTTTGCTTT
ATGGCCTATTTTGGGGTCTCTGCAGCTTTAACACTTATGATGCCGTACTACCTCCTCGAT
GAAAAAAGCCCCCTTCCTGTAGCGTTTGAATATGTGGGATGGGGTCCTGCCAAATATGTC
GTCGCAGCTGGTTCTCTCTGCGCCTTGTCAACAAGTCTTCTTGGATCCATTTTCCCAATG
CCTCGTGTAAACTATGCTATGGCGGAGGATGGGTTGCTTTTCAAATGTCTAGCTCAAATC
AATTCCAAAACGAAGACACCAATAATTGCTACTTTATCATCGGGTGCAGTGGCAGCTTTG
ATGGCCTTTCTGTTTGACCTGAAGGCGCTTGTGGACATGATGTCCATTGGCACACTCATG
GCCTACTCTCTGGTGGCAGCCTGTGTTCTCATCCTCAGGTACCAGCCTGGCTTATCTTAC
GACCAGCCCAAATGTTCTCCTGAGAAAGATGGTCTGGGATCGTCTCCCAGGGTAACCTCG
AAGAGTGAGTCCCAGGTCACCATGCTGCAGAGACAGGGCTTCAGCATGCGGACCCTCTTC
TGCCCCTCCCTTCTGCCAACACAGCAGTCAGCTTCTCTCGTGAGCTTTCTGGTAGGATTC
CTAGCTTTCCTCGTGTTGGGCCTGAGTGTCTTGACCACTTACGGAGTTCATGCCATCTAC
AGGCTGGAGGCCTGGAGCCTCGCTCTCCTCGCGCTGTTTCTTGTTCTCTTCGTTGCCATC
GTTCTCACCATCTGGAGGCAGCCCCAGAATCAACGAAAAGTAGCCTTCATGGTTCCATTC
TTACCATTTTTGCCGACGTTCACGATCTTGGTGAACATTTACTTGATGGTCCAGTTAAGT
GCAGACACTTGGGTCAGATTCAGCATTTGGATGGCAATTGGCTTCCTGATTTACTTTTCT
TATGGCATTAGACACAGCCTGGAGGGTCATCTGAGAGATGAAAACAATGAAGAAGATGCT
TATCCAGACAACGTTCATGCAGCAGCAGAAGAAAAATCTGCCATTCAAGCAAATGACCAT
CACCCAAGAAATCTCAGTTCACCTTTCATATTCCATGAAAAGACAAGTGAATTCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
D29990

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:8

# Macromolecular_Interacting_Partner_1_Locus:
8p22-p21.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs12680645; rs1134975; rs2517250; rs2299564; rs7838611; rs13259948; rs2285294; rs7842456; rs10093732; rs4921783; rs11987107; rs2285295; rs2517251; rs959426; rs2237817; rs3739416; rs956776; rs7827805; rs7842267; rs6586610; rs7014645; rs7822703; rs7842109; rs13275006; rs6980566; rs6998037; rs6983122; rs7842106; rs6991730; rs7823792; rs13281010; rs17124788; rs13282723; rs17124794; rs2705017; rs13398; rs2588241; rs13259978; rs2299566; rs11991148; rs13281204; rs14108; rs2299565; rs17504840; rs6999536; rs6998033; rs6982176; rs6998481; rs12156195; rs2301539; rs2588250; rs2720588; rs737039; rs2720590; rs3780121; rs2588252; rs2245491; rs2427721; rs2705062; rs10105500; rs2705018; rs2720559; rs6994712; rs2517254; rs2517257; rs2588248; rs2285293; rs2245492; rs2720558; rs10503597; rs2705061; rs17124818; rs2588247; rs2517252; rs2588243; rs2705019; rs6586609; rs17124823; rs17124830; rs10100359; rs17124809; rs2248010; rs17504917; rs11998060; rs2015840; rs10107764; rs17632706; rs2517253; rs17124843; rs7000018; rs2244738; rs2245183; rs17124835; rs6981597; rs2705065; rs9644582; rs2301540; rs2299567; rs11986520; rs2588246; rs17632632; rs11993109; rs7002951; rs17124783; rs17124778; rs2006214; rs17124777; rs6982625; rs885642; rs1134973; rs1804759; rs1981498; rs1134972; rs1134976; rs1134977; rs1134974; rs35978538; rs12156191; rs7826955; rs34780401; rs34068374; rs13271221; rs12155892; rs11427242; rs3959114; rs13275900; rs35741414; rs34091134; rs12156132; rs12155849; rs6980866; rs2248862; rs12156021; rs2237818; rs13280567; rs35506586; rs28615154; rs15239; rs28523587; rs34047096; rs3178072; rs35210464; rs10500; rs28520866; rs2705021; rs28573094; rs6991561; rs3173997; rs7827073; rs2427722; rs10645883; rs13253724; rs10112024; rs2588174; rs35923193; rs2588256; rs35409598; rs10658350; rs17124844; rs35737396; rs35838638; rs2588253; rs13279058; rs35596928; rs11373033; rs11203869; rs2285292; rs35252224; rs35949792; rs7014136; rs2440550; rs35268822; rs2517256; rs34282373; rs17124840; rs7017409; rs34882479; rs34699482; rs2588173; rs13279050; rs34982645; rs10104505; rs6996683; rs11203871; rs2588251; rs2588254; rs2427723; rs10100029; rs9792322; rs11373918; rs10658349; rs2720557; rs2588255; rs2705020; rs10654963; rs2440548; rs12155782; rs10658348; rs35052068; rs35618187; rs10658351; rs6996690; rs7828462; rs6989698; rs10106650; rs9644556; rs2466175; rs6150488; rs34146412; rs11203870; rs35800296; rs36061161; rs34817373; rs34505484; rs36099091; rs10087373; rs2588239; rs28617533; rs2720551; rs7462798; rs2720553; rs7003239; rs28733060; rs3178073; rs34272503; rs34626771; rs28616245; rs34194871; rs1003403; rs12156216; rs12679616; rs13263776; rs13268741; rs13272153; rs17124775; rs17632601; rs2517242; rs2517244; rs2517245; rs2517246; rs2517248; rs2517261; rs2517262; rs2517263; rs2517264; rs2517265; rs2517266; rs2517267; rs2588163; rs2588164; rs2588166; rs2588167; rs2588168; rs2588169; rs2588222; rs2588223; rs2588225; rs2588226; rs2588228; rs2588229; rs2588230; rs2588232; rs2588233; rs2588234; rs2588235; rs2705051; rs2705052; rs2705053; rs2705054; rs2705073; rs2705074; rs2705084; rs2720498; rs2720499; rs2720574; rs2720575; rs2720576; rs3214085; rs3780116; rs3780117; rs7016764; rs9792388

# Macromolecular_Interacting_Partner_1_General_References:
8954799

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8589

# Macromolecular_Interacting_Partner_2_Name:
Mitochondrial ornithine transporter 2

# Macromolecular_Interacting_Partner_2_Synonyms:
Solute carrier family 25 member 2

# Macromolecular_Interacting_Partner_2_Gene_Name:
SLC25A2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Mitochondrial ornithine transporter 2
MKSGPGIQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGL
RGFYKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFA
ALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQE
GPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLIVFPVDCIKSRIQVL
SMYGKQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMMMKQLEA
Y

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
301

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
32553

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
9.39

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  binding
Function:  transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  organelle membrane
Component:  organelle inner membrane
Component:  mitochondrial inner membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00153:Mito_carr

# Macromolecular_Interacting_Partner_2_Signals:
Not Available

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
5-25
68-88
110-130
168-188
210-230
237-257

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
13445628

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
ORNT2_HUMAN (Q9BXI2)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
SLC25A2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
SLC25A2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:22921

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>906 bp
ATGAAGTCCGGTCCTGGCATCCAAGCCGCCATCGACCTCACAGCGGGGGCCGCAGGGGGG
ACAGCGTGTGTACTGACTGGGCAGCCCTTCGACACAATAAAAGTGAAGATGCAGACGTTC
CCTGACCTGTACAAGGGCCTCACCGACTGCTTCCTGAAGACATACGCCCAAGTGGGTCTC
CGGGGCTTCTACAAGGGCACCGGCCCGGCACTTATGGCCTACGTCGCCGAAAACTCGGTC
CTCTTCATGTGCTACGGGTTCTGCCAGCAGTTTGTCAGGAAAGTGGCTGGAATGGACAAG
CAGGCAAAGCTGAGTGATCTCCAGACTGCAGCCGCGGGGTCCTTCGCCTCTGCATTTGCT
GCACTGGCTCTCTGCCCCACTGAGCTTGTGAAGTGCCGGCTACAGACCATGTATGAAATG
GAGATGTCAGGGAAGATAGCAAAAAGCCATAATACAATTTGGTCTGTCGTGAAGGGTATC
CTTAAAAAGGATGGCCCCTTGGGCTTCTACCATGGACTCTCGAGTACTCTACTTCAAGAA
GTACCGGGTTATTTCTTTTTCTTTGGTGGCTATGAACTGAGCCGATCGTTTTTTGCGTCA
GGGAGATCAAAAGATGAACTAGGCCCTGTCCATTTGATGTTAAGTGGTGGAGTTGCTGGA
ATTTGCCTGTGGCTTGTCGTGTTCCCAGTGGATTGTATTAAATCCAGAATTCAAGTTCTT
TCCATGTATGGGAAACAGGCAGGATTTATTGGTACCCTCTTAAGTGTTGTGAGAAATGAA
GGAATAGTAGCCTTATATTCTGGACTGAAAGCTACTATGATTCGAGCAATCCCTGCCAAT
GGGGCACTGTTTGTGGCCTACGAATACAGCAGGAAGATGATGATGAAACAGTTGGAAGCA
TACTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AF332005

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_2_Locus:
5q31

# Macromolecular_Interacting_Partner_2_SNPs:
rs3749779; rs10075302; rs3749780; rs11952797; rs6870500; rs10080079; rs10875594; rs7705024; rs7724001; rs10042612; rs34663948; rs3749781; rs28607677; rs13171955; rs1833657; rs10045849; rs10051645; rs10067231; rs1017086; rs10214106; rs10491308; rs10491309; rs10491310; rs1076361; rs11740372; rs12517262; rs12519400; rs12523208; rs13175150; rs13175163; rs13187825; rs13362262; rs17524297; rs35542565; rs6580184; rs6862672; rs6866612; rs6873682; rs6874200; rs6898211; rs758346; rs758347; rs7716531; rs7731867; rs7735993; rs7736152

# Macromolecular_Interacting_Partner_2_General_References:
11230163; 12948741

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8616

# Macromolecular_Interacting_Partner_3_Name:
Y+L amino acid transporter 1

# Macromolecular_Interacting_Partner_3_Synonyms:
y(+L-type amino acid transporter 1; y+LAT-1; Y+LAT1; Monocyte amino acid permease 2; MOP-2

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC7A7

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Y+L amino acid transporter 1
MVDSTEYEVASQPEVETSPLGDGASPGPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPK
GVLIYSASFGLSLVIWAVGGLFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRL
WTSLLIIEPTSQAIIAITFANYMVQPLFPSCFAPYAASRLLAAACICLLTFINCAYVKWG
TLVQDIFTYAKVLALIAVIVAGIVRLGQGASTHFENSFEGSSFAVGDIALALYSALFSYS
GWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYTVLDMRDILASDAVAVTF
ADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGHLPDAICMIHVERFTPVP
SLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWKEPDRPRPLKLSVFF
PIVFCLCTIFLVAVPLYSDTINSLIGIAIALSGLPFYFLIIRVPEHKRPLYLRRIVGSAT
RYLQVLCMSVAAEMDLEDGGEMPKQRDPKSN

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
511

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
55991

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
5.07

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
 Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_3_Specific_Function:
Sodium-independent exchanger of cationic and large neutral amino acids

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_3_Signals:
Not Available

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
37-57
69-89
107-127
133-153
160-180
186-206
222-242
259-279
304-324
383-403
416-436
441-461

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
4581435

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
YLA1_HUMAN (Q9UM01)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC7A7

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC7A7

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:11065

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; multi-pass membrane protein (Probable)

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1536 bp
ATGGTTGACAGCACTGAGTATGAAGTGGCCTCCCAGCCTGAGGTGGAAACCTCCCCTTTG
GGTGATGGGGCCAGCCCAGGGCCGGAGCAGGTGAAGCTGAAGAAGGAGATCTCACTGCTT
AACGGCGTGTGCCTGATTGTGGGGAACATGATCGGCTCAGGCATCTTTGTTTCCCCCAAG
GGTGTGCTCATATACAGTGCCTCCTTTGGTCTCTCTCTGGTCATCTGGGCTGTCGGGGGC
CTCTTCTCCGTCTTTGGGGCCCTTTGTTATGCGGAACTGGGCACCACCATTAAGAAATCT
GGGGCCAGCTATGCCTATATCCTGGAGGCCTTTGGAGGATTCCTTGCTTTCATCAGACTC
TGGACCTCCCTGCTCATCATTGAGCCCACCAGCCAGGCCATCATTGCCATCACCTTTGCC
AACTACATGGTACAGCCTCTCTTCCCGAGCTGCTTCGCCCCTTATGCTGCCAGCCGCCTG
CTGGCTGCTGCCTGCATCTGTCTCTTAACCTTCATTAACTGTGCCTATGTCAAATGGGGA
ACCCTGGTACAAGATATTTTCACCTATGCTAAAGTATTGGCACTGATCGCGGTCATCGTT
GCAGGCATTGTTAGACTTGGCCAGGGAGCCTCTACTCATTTTGAGAATTCCTTTGAGGGT
TCATCATTTGCAGTGGGTGACATTGCCCTGGCACTGTACTCAGCTCTGTTCTCCTACTCA
GGCTGGGACACCCTCAACTATGTCACTGAAGAGATCAAGAATCCTGAGAGGAACCTGCCC
CTCTCCATTGGCATCTCCATGCCCATTGTCACCATCATCTATATCTTGACCAATGTGGCC
TATTATACTGTGCTAGACATGAGAGACATCTTGGCCAGTGATGCTGTTGCTGTGACTTTT
GCAGATCAGATATTTGGAATATTTAACTGGATAATTCCACTGTCAGTTGCATTATCCTGT
TTTGGTGGCCTCAATGCCTCCATTGTGGCTGCTTCTAGGCTTTTCTTTGTGGGCTCAAGA
GAAGGCCATCTCCCTGATGCCATCTGCATGATCCATGTTGAGCGGTTCACACCAGTGCCT
TCTCTGCTCTTCAATGGTATCATGGCATTGATCTACTTGTGCGTGGAAGACATCTTCCAG
CTCATTAACTACTACAGCTTCAGCTACTGGTTCTTTGTGGGGCTTTCTATTGTGGGTCAG
CTTTATCTGCGCTGGAAGGAGCCTGATCGACCTCGTCCCCTCAAGCTCAGCGTTTTCTTC
CCGATTGTCTTCTGCCTCTGCACCATCTTCCTGGTGGCTGTTCCACTTTACAGTGATACT
ATCAACTCCCTCATCGGCATTGCCATTGCCCTCTCAGGCCTGCCCTTTTACTTCCTCATC
ATCAGAGTGCCAGAACATAAGCGACCGCTTTACCTCCGAAGGATCGTGGGGTCTGCCACA
AGGTACCTCCAGGTCCTGTGTATGTCAGTTGCTGCAGAAATGGATTTGGAAGATGGAGGA
GAGATGCCCAAGCAACGGGATCCCAAGTCTAACTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
Y18474

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_3_Locus:
14q11.2

# Macromolecular_Interacting_Partner_3_SNPs:
rs11568438; rs1805061; rs8018462; rs1805059; rs1061040; rs8016634; rs12432242; rs3829407; rs7157654; rs2281677; rs2281678; rs28364570; rs8003565; rs3901112; rs6572756; rs7359123; rs12884337; rs5027249; rs7144493; rs12433985; rs3850290; rs8006783; rs10134338; rs8013531; rs6572755; rs8005577; rs4981440; rs6572770; rs7151065; rs11568434; rs4981441; rs2065134; rs6572754; rs8006959; rs4316670; rs8009463; rs8008860; rs4981439; rs8020146; rs2331772; rs8006372; rs2025210; rs17211943; rs9671631; rs17122346; rs3850291; rs11568430; rs4982676; rs12879369; rs8013199; rs11568429; rs17122403; rs8008775; rs2065047; rs11568422; rs10145612; rs3850293; rs11847310; rs3829406; rs11848632; rs4605074; rs4982679; rs7157097; rs9323209; rs8006353; rs7140366; rs10133276; rs4982675; rs17277879; rs8008926; rs17277872; rs12436190; rs3751485; rs4982671; rs12436256; rs17122349; rs1885402; rs11157832; rs2065135; rs2146231; rs10133059; rs4982673; rs8010165; rs2331714; rs8006930; rs3887870; rs6572752; rs7160295; rs12888930; rs7155516; rs8006101; rs3932495; rs10220286; rs10145846; rs10459445; rs11157819; rs7150679; rs2065044; rs7153183; rs10147613; rs4982677; rs11851289; rs8021277; rs9707487; rs2331766; rs8006068; rs10135949; rs7151696; rs7157118; rs4982674; rs17277865; rs4981438; rs12891079; rs10134386; rs11157817; rs10145611; rs2065045; rs11850787; rs10133893; rs7150667; rs3934209; rs4981442; rs10459444; rs2331769; rs10135074; rs11628750; rs2208654; rs12894685; rs2331765; rs2331771; rs8004437; rs12146987; rs3934210; rs7158333; rs11157833; rs7144397; rs8006653; rs2065046; rs8018436; rs8011806; rs11851258; rs7146300; rs2331768; rs1885591; rs2146232; rs7156633; rs12147201; rs17211950; rs11157836; rs11628748; rs11844141; rs17122385; rs4982681; rs8019656; rs10130540; rs1951567; rs10130537; rs11157810; rs10135803; rs11846392; rs10151126; rs1951566; rs4982680; rs1951568; rs1951565; rs1138286; rs1805062; rs35323339; rs34654418; rs28548972; rs28485487; rs10644590; rs28588397; rs28464162; rs35753892; rs28505834; rs8014410; rs35748274; rs12888481; rs28579848; rs8022688; rs35328728; rs2331770; rs10647286; rs10151071; rs10459505; rs34583396; rs33950544; rs28365818; rs35503839; rs179032; rs35500075; rs36202986; rs35434647; rs36215780; rs35718984; rs12888484; rs8017726; rs4424818; rs34641571; rs35045479; rs34757325; rs2331767; rs33944126; rs179035; rs33999733; rs34304860; rs36057907; rs10574852; rs179034; rs11455079; rs12880108; rs3076449; rs10702514; rs35398636; rs12881095; rs10672329; rs8016877; rs7144980; rs4982678; rs28621046; rs2065043; rs35629342; rs35758383; rs3932494; rs3076446; rs12892586; rs11361255; rs10595302; rs35326556; rs34452181; rs35358049; rs34293345; rs35203597; rs11157834; rs36096362; rs10135308; rs1272495; rs36089060; rs35256849; rs10132846; rs33936906; rs36110354; rs33953244; rs4609758; rs4505232; rs28582652; rs35698214; rs10131662; rs179029; rs3850292; rs12892596; rs35501308; rs10146190; rs10595226; rs33982413; rs2181225; rs7141545; rs12147763; rs3076435; rs28590479; rs179031; rs179037; rs12886178; rs35197287; rs28502733; rs35564703; rs12892590; rs1271268; rs1983763; rs11397219; rs10597441; rs7157698; rs7148931; rs34386018; rs35710053; rs12881341; rs28588189; rs12892438; rs1269411; rs10133977; rs34215169; rs11430909; rs34673895; rs35259168; rs8022679; rs179028; rs8003677; rs11395030; rs10459506; rs12882521; rs10654866; rs35209286; rs35316014; rs7161536; rs34308809; rs4533185; rs28494892; rs10459443; rs179033; rs4246997; rs10141489; rs34772384; rs17122373; rs35050152; rs35892962; rs28516981; rs179030; rs12147511; rs34783556; rs179036; rs33921335; rs28653553; rs34759644; rs10673088; rs34516291; rs35750898; rs35737812; rs35843252; rs35431366; rs34172127; rs8011966; rs34004476; rs7140363; rs8019970; rs6572753; rs7160130; rs34340570; rs34748469; rs35859509; rs28515861; rs34312187; rs34862252; rs34842713; rs36046611; rs33995868; rs28432732; rs33950046; rs4982682; rs34878142; rs35065113; rs33989244; rs35273567; rs35520878; rs34994757; rs4982683; rs10147193; rs10135815; rs28759095; rs5807190; rs28377776; rs10614809; rs34033212; rs7151287; rs10625308; rs35535229; rs10614808; rs10136960; rs11568423; rs11568425; rs11568426; rs11568427; rs11568428; rs11568431; rs11568432; rs11568435; rs11568436; rs12435744; rs17122772; rs17122776; rs17122779; rs17122782; rs17243007; rs17619; rs1957373; rs1957374; rs1957502; rs1957503; rs2073344; rs2073345; rs2075846; rs2284992; rs3087824; rs34237480; rs34453264; rs35143092; rs3764163; rs3764164; rs4981436; rs4981437; rs6572731; rs7150444; rs8572; rs8786; rs9323208

# Macromolecular_Interacting_Partner_3_General_References:
9829974; 9878049; 10080183; 10737982; 10631139; 10655553

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8627

# Macromolecular_Interacting_Partner_4_Name:
4F2 cell-surface antigen heavy chain

# Macromolecular_Interacting_Partner_4_Synonyms:
4F2hc; Lymphocyte activation antigen 4F2 large subunit; 4F2 heavy chain antigen; CD98 antigen

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC3A2

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>4F2 cellsurface antigen heavy chain
MSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKF
TGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHT
GALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQID
PNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAG
VDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLT
SSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLP
GTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLS
LFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQAS
DLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYAA

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
529

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
57945

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
4.99

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  amylase activity
Function:  alpha-amylase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_4_Specific_Function:
Involved in sodium-independent, high-affinity transport of large neutral amino acids. Required for normal and neoplastic cell growth

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00128:Alpha-amylase

# Macromolecular_Interacting_Partner_4_Signals:
1-98

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
82-104

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
182865

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
4F2_HUMAN (P08195)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC3A2

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC3A2

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11026

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane; single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1590 bp
ATGAGCCAGGACACCGAGGTGGATATGAAGGAGGTGGAGCTGAATGAGTTAGAGCCCGAG
AAGCAGCCGATGAACGCGGCGTCTGGGGCGGCCATGTCCCTGGCGGGAGCCGAGAAGAAT
GGTCTGGTGAAGATCAAGGTGGCGGAAGACGAGGCGGAGGCGGCAGCCGCGGCTAAGTTC
ACGGGCCTGTCCAAGGAGGAGCTGCTGAAGGTGGCAGGCAGCCCCGGCTGGGTACGCACC
CGCTGGGCACTGCTGCTGCTCTTCTGGCTCGGCTGGCTCGGCATGCTTGCTGGTGCCGTG
GTCATAATCGTGCGAGCGCCGCGTTGTCGCGAGCTACCGGCGCAGAAGTGGTGGCACACG
GGCGCCCTCTACCGCATCGGCGACCTTCAGGCCTTCCAGGGCCACGGCGCGGGCAACCTG
GCGGGTCTGAAGGGGCGTCTCGATTACCTGAGCTCTCTGAAGGTGAAGGGCCTTGTGCTG
GGTCCAATTCACAAGAACCAGAAGGATGATGTCGCTCAGACTGACTTGCTGCAGATCGAC
CCCAATTTTGGCTCCAAGGAAGATTTTGACAGTCTCTTGCAATCGGCTAAAAAAAAGAGC
ATCCGTGTCATTCTGGACCTTACTCCCAACTACCGGGGTGAGAACTCGTGGTTCTCCACT
CAGGTTGACACTGTGGCCACCAAGGTGAAGGATGCTCTGGAGTTTTGGCTGCAAGCTGGC
GTGGATGGGTTCCAGGTTCGGGACATAGAGAATCTGAAGGATGCATCCTCATTCTTGGCT
GAGTGGCAAAATATCACCAAGGGCTTCAGTGAAGACAGGCTCTTGATTGCGGGGACTAAC
TCCTCCGACCTTCAGCAGATCCTGAGCCTACTCGAATCCAACAAAGACTTGCTGTTGACT
AGCTCATACCTGTCTGATTCTGGTTCTACTGGGGAGCATACAAAATCCCTAGTCACACAG
TATTTGAATGCCACTGGCAATCGCTGGTGCAGCTGGAGTTTGTCTCAGGCAAGGCTCCTG
ACTTCCTTCTTGCCGGCTCAACTTCTCCGACTCTACCAGCTGATGCTCTTCACCCTGCCA
GGGACCCCTGTTTTCAGCTACGGGGATGAGATTGGCCTGGATGCAGCTGCCCTTCCTGGA
CAGCCTATGGAGGCTCCAGTCATGCTGTGGGATGAGTCCAGCTTCCCTGACATCCCAGGG
GCTGTAAGTGCCAACATGACTGTGAAGGGCCAGAGTGAAGACCCTGGCTCCCTCCTTTCC
TTGTTCCGGCGGCTGAGTGACCAGCGGAGTAAGGAGCGCTCCCTACTGCATGGGGACTTC
CACGCGTTCTCCGCTGGGCCTGGACTCTTCTCCTATATCCGCCACTGGGACCAGAATGAG
CGTTTTCTGGTAGTGCTTAACTTTGGGGATGTGGGCCTCTCGGCTGGACTGCAGGCCTCC
GACCTGCCTGCCAGCGCCAGCCTCCCAGCCAAGGCTGACCTCCTGCTCAGCACCCAGCCA
GGCCGTGAGGAGGGCTCCCCTCTTGAGCTGGAACGCCTGAAACTGGAGCCTCACGAAGGG
CTGCTGCTCCGCTTCCCCTACGCGGCCTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
J02939

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_4_Locus:
11q13

# Macromolecular_Interacting_Partner_4_SNPs:
rs4726; rs6932; rs489381; rs10897300; rs10897301; rs10792362; rs3809075; rs12221878; rs481235; rs12577251; rs4567465; rs12794763; rs7104190; rs507101; rs7106901; rs12098955; rs561385; rs519473; rs12804553; rs12274689; rs7935096; rs2070870; rs2920155; rs2282477; rs1140538; rs7944051; rs3015957; rs11548759; rs1051342; rs11548756; rs1051289; rs1051290; rs1802910; rs1051237; rs1802911; rs11548760; rs1051285; rs12272749; rs35228448; rs540791; rs549706; rs11231260; rs543622; rs541444; rs34047097; rs35246991; rs1815840; rs3840765; rs11231257; rs544453; rs35881347; rs35320203; rs2957168; rs7130029; rs519425; rs541388; rs34176851; rs535854; rs35091612; rs7106895; rs2096559; rs473815; rs11318751; rs5792273; rs12797676; rs499294; rs34225665; rs3809074; rs2957166; rs7115838; rs12803557; rs521939; rs1938675; rs563394; rs1300138; rs12225962; rs2105515; rs36034735; rs486306; rs12788771; rs1212628; rs1286159; rs5792274; rs12794229; rs7117639; rs495776; rs11231259; rs12366036; rs509327; rs35657900; rs11231261; rs496788; rs35988334; rs12788770; rs34335071; rs1298673; rs766316; rs34722625; rs560603; rs11824602; rs565303; rs34494671; rs35455481; rs7101685; rs1286160; rs510307; rs12270563; rs11231254; rs11231262; rs11318752; rs549635; rs12270604; rs2957167; rs11317361; rs7126772; rs34436839; rs11341257; rs577134; rs11558674; rs1059292; rs11231249; rs11231250; rs12270342; rs12295052; rs1785940; rs2071036; rs2269353; rs2507820; rs2509678; rs2510083; rs3737388; rs3737389; rs4034; rs480730; rs493851; rs498751; rs524891; rs547248; rs560006

# Macromolecular_Interacting_Partner_4_General_References:
3476959; 3036867; 3480538; 3265470; 12754519; 11840567; 12270127

# Macromolecular_Interacting_Partner_4_References:
Not Available

# Macromolecular_Interacting_Partner_5_ID:
8646

# Macromolecular_Interacting_Partner_5_Name:
Hypothetical protein DKFZp686K14185

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
DKFZp686K14185

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Hypothetical protein DKFZp686K14185
MEAREPGRPTPTYHLVPNTSQSQVEEDVSSPPQRSSETMQLKKEISLLNGVSLVVGNMIG
SGIFVSPKGVPVHTASYGMSLIVWAIGGLFSVVGALCYAELGTTITKSGASYAYILEAFG
GFIAFIRLWVSLLVVEPTGQAIIAITFANYIIQPSLPSCDPPYLACRLLAAACICLLTFV
NCAYVKWGTRVQDTFTYAKVVALIAIIVMGLVKLCQEICPWPLGFLCQL

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
229

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
24657

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
7.12

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
 Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_5_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Signals:
Not Available

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
45-67; 77-99; 112-134; 163-185; 198-220

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
51476653

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
Q68DB5_HUMAN (Q68DB5)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
DKFZp686K14185

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
DKFZp686K14185

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:11064

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>690 bp
ATGGAAGCCAGGGAGCCTGGGAGGCCCACACCCACCTACCATCTTGTCCCTAACACCAGC
CAGTCCCAGGTGGAAGAAGATGTCAGCTCGCCACCTCAAAGGTCCTCCGAAACTATGCAG
CTGAAGAAGGAGATCTCCCTGCTGAATGGGGTCAGCCTGGTGGTGGGCAACATGATCGGC
TCAGGGATCTTTGTCTCACCCAAGGGTGTGCCGGTACACACTGCCTCCTATGGGATGTCA
CTGATTGTGTGGGCCATTGGTGGGCTCTTCTCTGTTGTGGGTGCCCTTTGTTATGCAGAG
CTGGGGACCACCATCACCAAGTCGGGAGCCAGCTACGCTTATATTCTAGAGGCCTTTGGG
GGCTTCATTGCCTTCATCCGCCTGTGGGTCTCACTGCTAGTTGTTGAGCCCACCGGTCAG
GCCATCATCGCCATCACCTTTGCCAACTACATCATCCAGCCGTCCCTCCCCAGCTGTGAT
CCCCCATACCTGGCCTGCCGTCTCCTGGCTGCTGCTTGCATATGTCTGCTGACATTTGTG
AACTGTGCCTATGTCAAGTGGGGCACACGTGTGCAGGACACGTTCACTTACGCCAAGGTC
GTAGCGCTCATTGCCATCATTGTCATGGGCCTTGTTAAACTGTGCCAGGAAATTTGCCCT
TGGCCATTGGGATTTCTATGCCAATTGTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
CR749475

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Locus:
Not Available

# Macromolecular_Interacting_Partner_5_SNPs:
Not Available

# Macromolecular_Interacting_Partner_5_General_References:
Not Available

# Macromolecular_Interacting_Partner_5_References:
Not Available

# Macromolecular_Interacting_Partner_6_ID:
8656

# Macromolecular_Interacting_Partner_6_Name:
Cationic amino acid transporter 3

# Macromolecular_Interacting_Partner_6_Synonyms:
CAT-3; Solute carrier family 7 member 3; Cationic amino acid transporter y+

# Macromolecular_Interacting_Partner_6_Gene_Name:
SLC7A3

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Cationic amino acid transporter 3
MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD
KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS
YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA
LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL
GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF
AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI
YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL
VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC
SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK
VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR
KSRAKTVDLDPGTLYVHSV

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
619

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
67170

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
6.11

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
 Function:  amino acid permease activity
Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
 Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_6_Specific_Function:
Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_6_Signals:
1-305

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
37-57
62-82
108-128
163-183
192-212
234-254
286-306
336-356
383-403
407-427
476-496
507-527
541-561
570-590

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
17224957

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
CTR3_HUMAN (Q8WY07)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SLC7A3

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SLC7A3

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:11061

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Cell membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1860 bp
ATGCCGTGGCAAGCATTTCGCAGATTTGGTCAAAAGCTGGTACGCAGACGTACACTGGAG
TCAGGCATGGCTGAGACTCGCCTTGCCAGATGCCTAAGCACCCTGGATTTAGTGGCCCTG
GGTGTGGGCAGCACATTGGGTGCAGGCGTGTATGTCCTAGCTGGCGAGGTGGCCAAAGAT
AAAGCAGGGCCATCCATTGTGATCTGCTTTTTGGTGGCTGCCCTGTCTTCTGTGTTGGCT
GGGCTGTGCTATGCGGAGTTTGGTGCCCGGGTTCCCCGTTCTGGTTCGGCATATCTCTAC
AGCTATGTCACTGTGGGTGAACTCTGGGCCTTCACCACTGGCTGGAACCTCATCCTCTCC
TATGTCATTGGTACAGCCAGTGTGGCCCGGGCCTGGAGCTCTGCTTTTGACAACCTGATT
GGGAACCACATCTCTAAGACTCTGCAGGGGTCCATTGCACTGCACGTGCCCCATGTCCTT
GCAGAATATCCAGATTTCTTTGCTTTGGGCCTCGTGTTGCTGCTCACTGGATTGTTGGCT
CTCGGGGCTAGTGAGTCGGCCCTGGTTACCAAAGTGTTCACAGGCGTGAACCTTTTGGTT
CTTGGGTTCGTCATGATCTCTGGCTTCGTTAAGGGGGACGTGCACAACTGGAAGCTCACA
GAAGAGGACTACGAATTGGCCATGGCTGAACTCAATGACACCTATAGCTTGGGTCCTCTG
GGCTCTGGAGGATTTGTGCCTTTCGGCTTCGAGGGAATTCTCCGTGGAGCAGCGACCTGT
TTCTATGCATTTGTTGGTTTCGACTGTATTGCTACCACTGGAGAAGAAGCCCAGAATCCC
CAGCGTTCCATCCCGATGGGCATTGTGATCTCACTGTCTGTCTGCTTTTTGGCGTATTTT
GCTGTCTCTTCTGCACTCACCCTGATGATGCCTTACTACCAGCTTCAGCCTGAGAGCCCT
TTGCCTGAGGCATTTCTCTACATTGGATGGGCTCCTGCCCGCTATGTTGTGGCTGTTGGC
TCCCTCTGTGCTCTTTCTACCAGCCTCCTGGGCTCCATGTTCCCCATGCCTCGGGTGATC
TACGCGATGGCAGAGGATGGCCTCCTGTTCCGTGTACTTGCTCGGATCCACACCGGCACA
CGCACCCCAATCATAGCCACCGTGGTCTCTGGCATTATTGCAGCATTCATGGCATTCCTC
TTCAAACTCACTGATCTTGTGGACCTCATGTCAATTGGGACCCTGCTTGCTTACTCCCTG
GTGTCGATTTGTGTTCTCATCCTCAGGTATCAACCTGATCAGGAGACAAAGACTGGGGAA
GAAGTGGAGTTGCAGGAGGAGGCAATAACTACTGAATCAGAGAAGTTGACCCTATGGGGA
CTATTTTTCCCACTCAACTCCATCCCCACTCCACTCTCTGGCCAAATTGTCTATGTTTGT
TCCTCATTGCTTGCTGTCCTGCTGACTGCTCTTTGCCTGGTGCTGGCCCAGTGGTCAGTT
CCATTGCTTTCTGGAGACCTGCTGTGGACTGCAGTGGTTGTGCTGCTCCTGCTGCTCATT
ATTGGGATCATTGTGGTCATCTGGAGACAGCCACAGAGTTCCACTCCCCTTCACTTTAAG
GTGCCTGCTTTGCCTCTCCTCCCACTAATGAGCATCTTTGTGAATATTTACCTTATGATG
CAGATGACAGCTGGTACCTGGGCCCGATTTGGGGTCTGGATGCTGATTGGCTTTGCTATC
TACTTCGGCTATGGGATCCAGCACAGCCTGGAAGAGATTAAGAGTAACCAACCCTCACGC
AAGTCTAGAGCCAAAACTGTAGACCTTGATCCCGGCACTCTCTATGTCCACTCAGTTTGA


# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
AF320612

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_6_Locus:
Xq13.1

# Macromolecular_Interacting_Partner_6_SNPs:
rs6525447; rs5936604; rs7885836; rs6625713; rs7890581; rs7886610; rs7891155; rs4524964; rs17853219; rs4360450; rs5902678; rs41310635; rs34548199; rs12556893; rs4844277; rs4844278; rs4844279; rs4844280; rs5936607; rs5936609; rs5936610; rs5937024; rs5937025; rs5981030; rs6624517; rs6625721; rs7881738

# Macromolecular_Interacting_Partner_6_General_References:
11591158

# Macromolecular_Interacting_Partner_6_References:
Not Available

# Macromolecular_Interacting_Partner_7_ID:
8673

# Macromolecular_Interacting_Partner_7_Name:
Sodium-coupled neutral amino acid transporter 4

# Macromolecular_Interacting_Partner_7_Synonyms:
Na(+-coupled neutral amino acid transporter 4; Amino acid transporter A3; System A amino acid transporter 3; System N amino acid transporter 3; Solute carrier family 38 member 4

# Macromolecular_Interacting_Partner_7_Gene_Name:
SLC38A4

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Sodiumcoupled neutral amino acid transporter 4
MDPMELRNVNIEPDDESSSGESAPDSYIGIGNSEKAAMSSQFANEDTESQKFLTNGFLGK
KKLADYADEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSL
YSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEV
IRAFMGLEENTGEWYLNGNYLIIFVSVGIILPLSLLKNLGYLGYTSGFSLTCMVFFVSVV
IYKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLPNNSESSDVNFMMDYTHRNPAGLDEN
QAKGSLHDSGVEYEAHSDDKCEPKYFVFNSRTAYAIPILVFAFVCHPEVLPIYSELKDRS
RRKMQTVSNISITGMLVMYLLAALFGYLTFYGEVEDELLHAYSKVYTLDIPLLMVRLAVL
VAVTLTVPIVLFPIRTSVITLLFPKRPFSWIRHFLIAAVLIALNNVLVILVPTIKYIFGF
IGASSATMLIFILPAVFYLKLVKKETFRSPQKVGALIFLVVGIFFMIGSMALIIIDWIYD
PPNSKHH

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
547

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
60765

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.45

# Macromolecular_Interacting_Partner_7_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_7_Specific_Function:
Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_7_Signals:
1-531

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
81-101
105-125
152-172
196-216
221-241
333-353
370-390
412-432
454-474
477-497
515-535

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
13876616

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
S38A4_HUMAN (Q969I6)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
SLC38A4

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
SLC38A4

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:14679

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Cell membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1644 bp
ATGGATCCCATGGAACTGAGAAATGTCAACATCGAACCAGATGATGAGAGCAGCAGTGGA
GAAAGTGCTCCAGATAGCTACATCGGGATAGGAAATTCAGAAAAGGCAGCAATGAGCAGT
CAATTTGCTAATGAAGACACTGAAAGTCAGAAATTCCTGACAAATGGATTTTTGGGGAAA
AAGAAGCTGGCAGATTATGCTGATGAACACCATCCCGGAACCACTTCCTTTGGAATGTCT
TCATTTAACCTGAGTAATGCCATCATGGGCAGTGGGATCCTGGGCTTGTCCTATGCCATG
GCCAACACAGGGATCATACTTTTTATAATCATGCTGCTTGCTGTGGCAATATTATCACTG
TATTCAGTTCACCTTTTATTAAAAACAGCCAAGGAAGGAGGGTCTTTGATTTATGAAAAA
TTAGGAGAAAAGGCATTTGGATGGCCGGGAAAAATTGGAGCTTTTGTTTCCATTACAATG
CAGAACATTGGAGCAATGTCAAGCTACCTCTTTATCATTAAATATGAACTACCTGAAGTA
ATCAGAGCATTCATGGGACTTGAAGAAAATACTGGAGAATGGTACCTCAATGGCAACTAC
CTCATCATATTTGTGTCTGTTGGAATTATTCTTCCACTTTCGCTCCTTAAAAATTTAGGT
TATCTTGGCTATACCAGTGGATTTTCTCTTACCTGCATGGTGTTTTTTGTTAGTGTGGTG
ATTTACAAGAAATTCCAAATACCCTGCCCTCTACCTGTTTTGGATCACAGTGTTGGAAAT
CTGTCATTCAACAACACGCTTCCAATGCATGTGGTAATGTTACCCAACAACTCTGAGAGT
TCTGATGTGAACTTCATGATGGATTACACCCACCGCAATCCTGCAGGGCTGGATGAGAAC
CAGGCCAAGGGCTCTCTTCATGACAGTGGAGTAGAATATGAAGCTCATAGTGATGACAAG
TGTGAACCCAAATACTTTGTATTCAACTCCCGGACGGCCTATGCAATTCCTATCCTAGTA
TTTGCTTTTGTATGCCACCCTGAGGTCCTTCCCATCTACAGTGAACTTAAAGATCGGTCC
CGGAGAAAAATGCAAACGGTGTCAAATATTTCCATCACGGGGATGCTTGTCATGTACCTG
CTTGCCGCCCTCTTTGGTTACCTAACCTTCTATGGAGAAGTTGAAGATGAATTACTTCAT
GCCTACAGCAAAGTGTATACATTAGACATCCCTCTTCTCATGGTTCGCCTGGCAGTCCTT
GTGGCAGTAACACTAACTGTGCCCATTGTCCTCTTCCCAATTCGTACATCAGTGATCACA
CTGTTATTTCCCAAACGACCCTTCAGCTGGATACGACATTTCCTGATTGCAGCTGTGCTT
ATTGCACTTAATAATGTTCTGGTCATCCTTGTGCCAACTATAAAATACATCTTCGGATTC
ATAGGGGCTTCTTCTGCCACTATGCTGATTTTTATTCTTCCAGCAGTTTTTTATCTTAAA
CTTGTCAAGAAAGAAACTTTTAGGTCACCCCAAAAGGTCGGGGCTTTAATTTTCCTTGTG
GTTGGAATATTCTTCATGATTGGAAGCATGGCACTCATTATAATTGACTGGATTTATGAT
CCTCCAAATTCCAAGCATCACTAA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
AF305814

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_7_Locus:
12q13

# Macromolecular_Interacting_Partner_7_SNPs:
rs2429467; rs11183610; rs180414; rs2465604; rs2429472; rs2250010; rs2191162; rs2715788; rs2465608; rs2430921; rs4627160; rs11183605; rs180438; rs2897981; rs10881001; rs2079787; rs7974413; rs11183618; rs2429470; rs4482114; rs11183617; rs7963399; rs11183616; rs7967842; rs4587804; rs7132006; rs10161209; rs2109125; rs11183619; rs2465605; rs3862137; rs4569081; rs11183620; rs12321267; rs12582305; rs12424453; rs7968752; rs7954772; rs2429473; rs7963807; rs2465586; rs17097332; rs4447249; rs7138295; rs7959916; rs7953215; rs7973308; rs12304394; rs4491335; rs180437; rs12301396; rs10748455; rs2429471; rs12300935; rs4554975; rs12318696; rs10437941; rs7963364; rs10881002; rs7971412; rs7974393; rs12227634; rs17666239; rs12301345; rs11183621; rs17097341; rs10881003; rs180430; rs180431; rs2715779; rs2465585; rs180416; rs2465584; rs180421; rs1860372; rs180408; rs180433; rs180410; rs180409; rs180420; rs180417; rs7297226; rs4768758; rs2287471; rs180427; rs180419; rs2429474; rs4768759; rs2430922; rs2465583; rs6582676; rs180407; rs11183608; rs2465582; rs180434; rs180405; rs11183609; rs180426; rs180435; rs180412; rs2465644; rs12307687; rs180424; rs180429; rs180415; rs17097246; rs2075335; rs12305532; rs180428; rs12316767; rs2287472; rs12581848; rs12307218; rs4768757; rs180425; rs12317419; rs12306007; rs3794308; rs12301214; rs2302855; rs180423; rs180403; rs17097220; rs12313427; rs17602430; rs1860371; rs12826359; rs180422; rs2429465; rs2287473; rs17097286; rs11609184; rs2429466; rs180436; rs180404; rs1468970; rs1468972; rs1468971; rs2465614; rs4340151; rs2430920; rs2465613; rs12315893; rs7489259; rs7976413; rs7962993; rs7965688; rs7976286; rs4262792; rs12309262; rs35448881; rs5797999; rs12426237; rs34557682; rs10523982; rs12824626; rs2543339; rs4537845; rs34666594; rs2429469; rs10161451; rs34886536; rs5798000; rs4575359; rs11558891; rs9804926; rs10693721; rs4388977; rs2430923; rs2429468; rs34878223; rs3764027; rs2465606; rs2465588; rs35064296; rs17097355; rs34251832; rs12308177; rs1072246; rs2465587; rs4335624; rs5798001; rs2907513; rs12819255; rs4768756; rs2532606; rs11370884; rs34540549; rs12298652; rs34594658; rs4623983; rs35779004; rs35709312; rs2429464; rs10691485; rs12832145; rs35826321; rs180413; rs2216433; rs35066357; rs12319423; rs2465616; rs10691484; rs11610757; rs11315253; rs34637197; rs17097192; rs35050099; rs7313706; rs549755; rs36053062; rs11335369; rs3217194; rs11183614; rs12318924; rs4631970; rs34909119; rs12316757; rs180411; rs180432; rs10673975; rs34246069; rs35085914; rs180406; rs34654635; rs34189139; rs11335992; rs4439596; rs416435; rs35774013; rs5797998; rs3958775; rs35668113; rs446993; rs180418; rs34764764; rs34209899; rs11338774; rs10785645; rs11183625; rs11609070; rs11615573; rs12307895; rs12311057; rs12317975; rs12318756; rs12318994; rs12812119; rs17097368; rs17684703; rs2193649; rs2216432; rs2408623; rs2430917; rs2430919; rs2465595; rs2715775; rs2715783; rs4374015; rs4495962; rs4497488; rs4511364; rs4533116; rs4994910; rs7953233; rs7955552; rs7964210; rs7978689; rs7978822; rs7978926

# Macromolecular_Interacting_Partner_7_General_References:
11342143; 11414754

# Macromolecular_Interacting_Partner_7_References:
Not Available

# Macromolecular_Interacting_Partner_8_ID:
8787

# Macromolecular_Interacting_Partner_8_Name:
High-affinity cationic amino acid transporter 1

# Macromolecular_Interacting_Partner_8_Synonyms:
CAT-1; CAT1; System Y+ basic amino acid transporter; Ecotropic retroviral leukemia receptor homolog; ERR; Ecotropic retrovirus receptor homolog

# Macromolecular_Interacting_Partner_8_Gene_Name:
SLC7A1

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Highaffinity cationic amino acid transporter 1
MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE
NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS
YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT
LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG
KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA
YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR
VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY
SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI
LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA
VVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIY
FGYGLWHSEEASLDADQARTPDGNLDQCK

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
629

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
67639

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
5.06

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
 Function:  amino acid permease activity
Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
 Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_8_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_8_Specific_Function:
High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_8_Signals:
1-540

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
36-57
62-82
103-123
163-183
192-212
247-267
288-307
338-358
385-405
409-429
493-513
527-551
560-580
585-605

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
36161

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
CTR1_HUMAN (P30825)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
SLC7A1

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
SLC7A1

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:11057

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1890 bp
ATGGGGTGCAAAGTCCTGCTCAACATTGGGCAGCAGATGCTGCGGCGGAAGGTGGTGGAC
TGTAGCCGGGAGGAGACGCGGCTGTCTCGCTGCCTGAACACTTTTGATCTGGTGGCCCTC
GGGGTGGGCAGCACACTGGGTGCTGGTGTCTACGTCCTGGCTGGAGCTGTGGCCCGTGAG
AATGCAGGCCCTGCCATTGTCATCTCCTTCCTGATCGCTGCGCTGGCCTCAGTGCTGGCT
GGCCTGTGCTATGGCGAGTTTGGTGCTCGGGTCCCCAAGACGGGCTCAGCTTACCTCTAC
AGCTATGTCACCGTTGGAGAGCTCTGGGCCTTCATCACCGGCTGGAACTTAATCCTCTCC
TACATCATCGGTACTTCAAGCGTAGCGAGGGCCTGGAGCGCCACCTTCGACGAGCTGATA
GGCAGACCCATCGGGGAGTTCTCACGGACACACATGACTCTGAACGCCCCCGGCGTGCTG
GCTGAAAACCCCGACATATTCGCAGTGATCATAATTCTCATCTTGACAGGACTTTTAACT
CTTGGTGTGAAAGAGTCGGCCATGGTCAACAAAATATTCACTTGTATTAACGTCCTGGTC
CTGGGCTTCATAATGGTGTCAGGATTTGTGAAAGGATCGGTTAAAAACTGGCAGCTCACG
GAGGAGGATTTTGGGAACACATCAGGCCGTCTCTGTTTGAACAATGACACAAAAGAAGGG
AAGCCCGGTGTTGGTGGATTCATGCCCTTCGGGTTCTCTGGTGTCCTGTCGGGGGCAGCG
ACTTGCTTCTATGCCTTCGTGGGCTTTGACTGCATCGCCACCACAGGTGAAGAGGTGAAG
AACCCACAGAAGGCCATCCCCGTGGGGATCGTGGCGTCCCTCTTGATCTGCTTCATCGCC
TACTTTGGGGTGTCGGCTGCCCTCACGCTCATGATGCCCTACTTCTGCCTGGACAATAAC
AGCCCCCTGCCCGACGCCTTTAAGCACGTGGGCTGGGAAGGTGCCAAGTACGCAGTGGCC
GTGGGCTCCCTCTGCGCTCTTTCCGCCAGTCTTCTAGGTTCCATGTTTCCCATGCCTCGG
GTTATCTATGCCATGGCTGAGGATGGACTGCTATTTAAATTCTTAGCCAACGTCAATGAT
AGGACCAAAACACCAATAATCGCCACATTAGCCTCGGGTGCCGTTGCTGCTGTGATGGCC
TTCCTCTTTGACCTGAAGGACTTGGTGGACCTCATGTCCATTGGCACTCTCCTGGCTTAC
TCGTTGGTGGCTGCCTGTGTGTTGGTCTTACGGTACCAGCCAGAGCAGCCTAACCTGGTA
TACCAGATGGCCAGTACTTCCGACGAGTTAGATCCAGCAGACCAAAATGAATTGGCAAGC
ACCAATGATTCCCAGCTGGGGTTTTTACCAGAGGCAGAGATGTTCTCTTTGAAAACCATA
CTCTCACCCAAAAACATGGAGCCTTCCAAAATCTCTGGGCTAATTGTGAACATTTCAACC
AGCCTTATAGCTGTTCTCATCATCACCTTCTGCATTGTGACCGTGCTTGGAAGGGAGGCT
CTCACCAAAGGGGCGCTGTGGGCAGTCTTTCTGCTCGCAGGGTCTGCCCTCCTCTGTGCC
GTGGTCACGGGCGTCATCTGGAGGCAGCCCGAGAGCAAGACCAAGCTCTCATTTAAGGTT
CCCTTCCTGCCAGTGCTCCCCATCCTGAGCATCTTCGTGAACGTCTATCTCATGATGCAG
CTGGACCAGGGCACCTGGGTCCGGTTTGCTGTGTGGATGCTGATAGGCTTCATCATCTAC
TTTGGCTATGGCCTGTGGCACAGCGAGGAGGCGTCCCTGGATGCCGACCAAGCAAGGACT
CCTGACGGCAACTTGGACCAGTGCAAGTGA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
X59155

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:13

# Macromolecular_Interacting_Partner_8_Locus:
13q12-q14

# Macromolecular_Interacting_Partner_8_SNPs:
rs2482090; rs2482089; rs2277451; rs34747283; rs34981623; rs34374153; rs1571784; rs914362; rs1984029; rs3013641; rs532568; rs1571786; rs1546534; rs537151; rs280922; rs485359; rs9551699; rs476506; rs166828; rs280933; rs280930; rs9551700; rs7997827; rs2989596; rs2277452; rs280923; rs1984030; rs11839516; rs866573; rs280936; rs2490264; rs579451; rs1877463; rs819388; rs7338758; rs6490412; rs280934; rs280918; rs280950; rs7328329; rs3013640; rs6490411; rs280928; rs9579412; rs9579400; rs659314; rs928352; rs11617418; rs819386; rs11616506; rs3011605; rs280927; rs9579402; rs645783; rs528336; rs2776949; rs476931; rs478085; rs617892; rs7998704; rs12428751; rs1018679; rs10870625; rs555913; rs928353; rs7981502; rs9579401; rs10454589; rs11618529; rs928354; rs2482087; rs9579397; rs2989594; rs11842773; rs3011624; rs819385; rs9314962; rs9579406; rs10454590; rs17661173; rs9579405; rs1275359; rs1275360; rs3011623; rs1756442; rs280919; rs645778; rs12427581; rs3803266; rs280924; rs9578106; rs2776408; rs1756444; rs595454; rs9579411; rs4769759; rs11838366; rs9578108; rs17073704; rs11843711; rs9314960; rs12864238; rs11843217; rs280926; rs2776948; rs166827; rs2669039; rs9579398; rs9508499; rs581455; rs521924; rs13378570; rs1756440; rs2669038; rs583804; rs9285066; rs2277453; rs41318021; rs533768; rs280954; rs10220050; rs9578107; rs1756439; rs9314961; rs9579407; rs280931; rs9579408; rs521122; rs280925; rs280935; rs1571785; rs17602182; rs9551696; rs7328185; rs280917; rs2989595; rs1124594; rs9579410; rs3011604; rs1707099; rs11840806; rs532499; rs1756438; rs9506206; rs9550482; rs17073661; rs4769760; rs280946; rs3803268; rs17073703; rs1756441; rs280947; rs2802249; rs2802240; rs2490266; rs3011625; rs2802252; rs2183717; rs2776955; rs2776959; rs6490410; rs11838370; rs3783259; rs2989592; rs2776960; rs2482093; rs1411928; rs2490265; rs2274837; rs2150689; rs6490409; rs2776956; rs2490267; rs2989593; rs3825536; rs883055; rs2776957; rs3783248; rs3783263; rs2150693; rs9579393; rs3783257; rs9578105; rs3783252; rs2776953; rs12428026; rs9579389; rs9579392; rs2776963; rs2802250; rs2150688; rs2802251; rs2150690; rs9579391; rs17073593; rs1018680; rs2482091; rs7993193; rs9578103; rs9579383; rs3783262; rs3783260; rs2236499; rs2482094; rs2776961; rs17073592; rs3011626; rs9550477; rs9579395; rs2026322; rs11842525; rs2150692; rs7336765; rs9579386; rs2802248; rs17603017; rs2026321; rs1018682; rs2482092; rs17602454; rs9578104; rs7318388; rs7338132; rs2802247; rs3783261; rs12875683; rs3783256; rs9579384; rs2776958; rs2150687; rs2183716; rs17660515; rs9579388; rs2150691; rs9579390; rs9508484; rs9579387; rs2776981; rs2776978; rs2802243; rs2776979; rs2802244; rs1005720; rs2776980; rs2802245; rs7991247; rs9578112; rs1005719; rs9578111; rs34072234; rs36015789; rs9508482; rs36125077; rs34941634; rs11315574; rs35198653; rs9551703; rs9551701; rs34054173; rs577666; rs280915; rs9579399; rs10712529; rs2989597; rs34597896; rs3184811; rs1330940; rs553271; rs9579382; rs1330941; rs15376; rs657993; rs8002439; rs280937; rs28595095; rs11305795; rs36114772; rs7320543; rs1756437; rs34719566; rs10219858; rs34218459; rs9508481; rs34369885; rs819389; rs34568566; rs280916; rs9551702; rs34978805; rs2989343; rs34967062; rs34479939; rs1756443; rs35992531; rs12868663; rs11348485; rs9579381; rs819392; rs34676366; rs7318650; rs9551698; rs34831702; rs280912; rs34563180; rs9578110; rs1756436; rs9579415; rs280955; rs9579414; rs3837577; rs36029139; rs1973624; rs34299140; rs34361702; rs35639325; rs11460300; rs35434476; rs35321601; rs9579404; rs34351045; rs280913; rs643986; rs3840002; rs36035912; rs34000939; rs2776950; rs9508497; rs34757816; rs34015769; rs9551697; rs860203; rs554904; rs34185884; rs9550483; rs3069134; rs34323634; rs522946; rs280929; rs35499262; rs3011607; rs34578457; rs35375275; rs35332203; rs9508490; rs2137395; rs34460584; rs3011608; rs819391; rs36006415; rs175973; rs558623; rs12872613; rs35196293; rs280932; rs12429742; rs645278; rs478688; rs28635114; rs7991883; rs634006; rs35694290; rs11276846; rs9508493; rs35321845; rs11315575; rs28420801; rs34318271; rs554179; rs9579403; rs9314963; rs36010538; rs11342640; rs13378143; rs2669037; rs9579413; rs35344478; rs2776409; rs280914; rs11305796; rs7491758; rs819390; rs678844; rs35926133; rs553069; rs11321368; rs4769763; rs9579396; rs35303712; rs9550481; rs33910194; rs280956; rs3011606; rs12164856; rs9508501; rs527380; rs4280096; rs34087661; rs28661387; rs11839594; rs615487; rs35061715; rs12868785; rs34109300; rs10601093; rs3066083; rs9579394; rs34156069; rs9551694; rs17660403; rs2776952; rs35186629; rs4769757; rs34496705; rs34724516; rs28510575; rs883056; rs7321163; rs34839020; rs35134959; rs914361; rs35662476; rs2776954; rs9579385; rs35457554; rs10685808; rs34847757; rs4002219; rs9551693; rs34286791; rs34296494; rs1018681; rs35597255; rs34444950; rs3066085; rs35860131; rs7358958; rs9551695; rs3837579; rs9550478; rs5802525; rs36066583; rs4002218; rs9579416; rs879427; rs9578102; rs7991463; rs11618507; rs11842710; rs172179; rs2482096; rs2482097; rs2490268; rs2776982; rs2776983; rs2776984; rs2776985; rs2776986; rs2802246; rs3011619; rs3011620; rs34778716; rs4769015; rs529696; rs558107; rs598281; rs7333364; rs7333533; rs7333701; rs7986532; rs7990747; rs7996343; rs7996508; rs7999739; rs7999905; rs8000157; rs882953; rs9508495; rs9508502; rs9551705; rs9578113; rs9578114; rs9579380; rs9579417; rs9579421; rs9579422; rs9579424; rs9579425; rs9805210; rs9805211

# Macromolecular_Interacting_Partner_8_General_References:
1718082; 1348489; 10485994

# Macromolecular_Interacting_Partner_8_References:
Not Available

# Macromolecular_Interacting_Partner_9_ID:
8881

# Macromolecular_Interacting_Partner_9_Name:
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

# Macromolecular_Interacting_Partner_9_Synonyms:
Amino acid transporter ATB0+; Solute carrier family 6 member 14

# Macromolecular_Interacting_Partner_9_Gene_Name:
SLC6A14

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Sodium and chloridedependent neutral and basic amino acid transporter B0+
MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVW
RFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGIT
MVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNK
GIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLA
LCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQ
SNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVF
AGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLG
LDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHF
CAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAI
FIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCC
RPASNWGPYLEQHRGERYKDMVDPKKEADHEIPTVSGSRKPE

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
642

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
72154

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
8.27

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
 Function:  transporter activity
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_9_Signals:
1-469

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
45-65
72-92
110-130
235-255
261-281
315-335
348-368
399-419
450-477
480-500
528-548
563-583

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
5732680

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
S6A14_HUMAN (Q9UN76)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
SLC6A14

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
SLC6A14

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:11047

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>1929 bp
ATGGACAAGTTGAAATGCCCGAGTTTCTTCAAGTGCAGGGAGAAGGAGAAAGTGTCGGCT
TCATCAGAGAATTTCCATGTTGGTGAAAATGATGAGAATCAGGACCGTGGTAACTGGTCC
AAAAAATCGGATTATCTTCTATCTATGATTGGATACGCAGTGGGATTAGGAAATGTGTGG
AGATTTCCATATCTGACCTACAGCAATGGTGGAGGCGCCTTCTTGATACCTTATGCAATT
ATGTTAGCATTGGCTGGTTTACCTTTGTTCTTTCTGGAGTGTTCACTGGGACAATTTGCT
AGCTTAGGTCCAGTTTCAGTTTGGAGGATTCTTCCATTGTTTCAAGGTGTGGGAATTACA
ATGGTCCTGATCTCCATTTTTGTGACAATCTATTACAATGTCATAATTGCCTATAGTCTT
TACTACATGTTTGCTTCTTTTCAAAGTGAACTACCATGGAAAAATTGTTCTTCGTGGTCA
GATAAAAACTGTAGCAGATCACCAATAGTAACTCACTGTAATGTGAGTACAGTGAATAAA
GGAATACAAGAGATCATCCAAATGAATAAAAGCTGGGTAGACATCAACAATTTTACCTGC
ATCAACGGCAGTGAAATTTATCAGCCAGGGCAGCTTCCCAGTGAACAATATTGGAATAAA
GTGGCGCTCCAACGGTCAAGTGGAATGAATGAGACTGGAGTAATTGTTTGGTATTTAGCA
CTTTGTCTTCTTCTGGCTTGGCTCATAGTTGGAGCAGCACTATTTAAAGGAATCAAATCG
TCTGGCAAGGTGGTATATTTTACAGCTCTTTTCCCCTATGTGGTCCTACTCATCCTGTTA
GTACGAGGTGCAACTCTGGAGGGTGCTTCAAAAGGCATTTCATACTATATTGGAGCCCAG
TCAAATTTTACAAAACTTAAGGAAGCTGAGGTATGGAAAGATGCTGCCACTCAGATATTT
TACTCCCTTTCAGTGGCTTGGGGTGGCTTAGTTGCTCTATCATCTTACAATAAGTTCAAA
AACAACTGCTTCTCTGATGCCATTGTGGTTTGTTTGACAAACTGTCTCACTAGCGTGTTT
GCTGGATTTGCTATTTTTTCTATATTGGGACACATGGCCCATATATCTGGAAAGGAAGTT
TCTCAAGTTGTAAAATCAGGTTTTGATTTGGCATTCATTGCCTATCCAGAGGCTCTAGCC
CAACTCCCAGGTGGTCCATTTTGGTCCATATTATTTTTTTTCATGCTTTTAACTTTGGGT
CTCGATTCTCAGTTTGCTTCGATTGAAACGATCACAACAACAATTCAAGATTTATTTCCC
AAAGTGATGAAGAAAATGAGGGTTCCCATAACTTTGGGCTGCTGCTTGGTTTTGTTTCTC
CTTGGTCTCGTCTGTGTGACTCAGGCTGGAATTTACTGGGTTCATCTGATTGACCACTTC
TGTGCTGGATGGGGCATTTTAATTGCAGCTATACTGGAGCTAGTTGGAATCATCTGGATT
TATGGAGGGAACAGATTCATTGAGGATACAGAAATGATGATTGGAGCAAAGAGGTGGATA
TTCTGGCTATGGTGGAGAGCTTGCTGGTTTGTAATTACGCCTATCCTTTTGATTGCAATA
TTTATCTGGTCATTGGTGCAATTTCATAGACCTAATTATGGCGCAATTCCATACCCTGAC
TGGGGAGTTGCTTTAGGCTGGTGTATGATTGTTTTCTGCATTATTTGGATACCAATTATG
GCTATCATAAAAATAATTCAGGCTAAAGGAAACATCTTTCAACGCCTTATAAGTTGCTGC
AGACCAGCTTCTAACTGGGGTCCATACCTGGAACAACATCGTGGGGAAAGATATAAAGAC
ATGGTAGATCCTAAAAAAGAGGCTGACCATGAAATACCTACTGTTAGTGGCAGCAGAAAA
CCGGAATGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
AF151978

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_9_Locus:
Xq23-q24

# Macromolecular_Interacting_Partner_9_SNPs:
rs12720074; rs2011162; rs5905179; rs12710570; rs5905289; rs2011198; rs2312055; rs2032525; rs5905176; rs5905284; rs7059155; rs2071877; rs4824325; rs10217924; rs5905178; rs6608646; rs12392462; rs2312057; rs12391221; rs17242824; rs5905288; rs12559530; rs10218102; rs10521579; rs12710569; rs10521578; rs5905285; rs5952101; rs12720080; rs12720088; rs5952099; rs12720083; rs5905177; rs4824358; rs4824324; rs12720076; rs4824359; rs12720084; rs12720079; rs5952103; rs2312056; rs12720089; rs17095419; rs12393509; rs4824323; rs2312054; rs7052454; rs12710568; rs12720073; rs12834312; rs3788766; rs5905283; rs12720085; rs28523889; rs6608648; rs11350870; rs34685017; rs28699570; rs12720092; rs28628632; rs12720078; rs5952174; rs35604008; rs5952104; rs5905287; rs6608645; rs12388847; rs10629819; rs12720087; rs12720091; rs35269408; rs17308739; rs3043424; rs35542990; rs5952100; rs5952102; rs35201069; rs6651554; rs12720077; rs10218234; rs6608647; rs12858125; rs34117081; rs5952175; rs12720082; rs34490652; rs4068397; rs7066547; rs7054956; rs12832551; rs10218418; rs12720075; rs12720086; rs12720090; rs35315031; rs7062559; rs10218017; rs12390279; rs12833869; rs12835480; rs12839137; rs12844003; rs17308697; rs2103697; rs2301451; rs5952181; rs6520234; rs6608511; rs6608514; rs6608644; rs6608650

# Macromolecular_Interacting_Partner_9_General_References:
10446133

# Macromolecular_Interacting_Partner_9_References:
Not Available

End of HMDB00182

Beginning of HMDB00186
# Accession_No:
HMDB00186

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-07-10 12:30:43

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
alpha-Lactose

# Description:
A disaccharide of glucose and galactose in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.
Lactose is a disaccharide that consists of &#946;-D-galactose and &#946;-D-glucose molecules bonded through a &#946;1-4 glycosidic linkage. Lactose makes up around 2-8% of the solids in milk. (Wikipeida)

# Synonyms:
(+)-lactose; 1-beta-D-Galactopyranosyl-4-alpha-D-glucopyranose; 4-O-Hexopyranosylhexose; Aletobiose; Anhydrous lactose; Lactin; Lactobiose; Lactose; Milk sugar; Osmolactan; Saccharum lactin; 1-beta-delta-Galactopyranosyl-4-alpha-delta-glucopyranose

# Chemical_IUPAC_Name:
(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3R,4S,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-oxane-3,4,5-triol

# Chemical_Formula:
C12H22O11

# Chemical_Structure:
tbl_chemical:::HMDB00186_ZOOM.png:::119283239248622804

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00186_THUMB.png:::119283239044172266

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Carbohydrates

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
1,2-diol; acetal; hemiacetal; heterocyclic compound; primary alcohol; secondary alcohol

# Taxonomy_Biofunction:
Component of Galactose metabolism; Component of Glycerolipid metabolism; Component of Glycosphingolipid metabolism; Component of Keratan sulfate biosynthesis; Component of N-Glycan biosynthesis

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
342.11621

# Molecular_Weight_Avg:
342.29651

# Smiles_String_isomeric:
OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO)O[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O

# Smiles_String_canonical:
OCC1OC(OC2C(CO)OC(O)C(O)C2O)C(O)C(O)C1O

# KEGG_Compound_ID:
C00243

# BioCyc_ID:
LACTOSE

# PubChem_CID:
84571

# PubChem_SID:
10220749; 11539037; 12216796; 14717756; 14719626; 15292679; 3542; 583863; 661460; 7847114; 7887889; 7888615; 8025606; 826871; 834908; 854534

# OMIM_ID:
150220; 223000; 223100; 230200

# Metagene_ID:
LACTOSE INTOLERANCE: 50; FANCONI-BICKEL SYNDROME: 436; GALACTOSEMIA II (GALK): 134; GALACTOSEMIA III: 139; PATENT DUCTUS VENOSUS: 460; GALACTOSEMIA: 136; LACTASE DEFICIENCY, CONGENITAL: 62; GLUCOSE-GALACTOSE MALABSORPTION: 150

# BiGG_ID:
34366

# Wikipedia_ID:
Lactose

# METLIN_ID:
267

# Ref_ID:
7852273; 15746338; 15015891; 16413377; 578795; 15745382; 1421750; 15745082; 65606; 12949114; 7787155; 15741771; 15662762; 9649604; 14702580

# ChEBI_ID:
36219

# CAS_Registry_Number:
63-42-3

# InChI:
InChI=1/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11+,12+/m1/s1

# Synthesis_Reference:
Takeo, K. et al., Carbohydr. Res., 1983, 121, 163

# Melting_Point:
201-202 oC

# Melting_Point_predicted:
140.9 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
195 mg/mL at 20 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
586.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-3.00 [Predicted by ALOGPS]; -4.3 [Predicted by PubChem via XLOGP]; -5.03 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::1166042895.html:::160787574312952>>>tbl_chemical:::1166042855.pdf:::148596740586268

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::1166042902.mol:::128795871305617

# SDF_File_[Text]:
tbl_chemical:::HMDB00186.sdf:::119283238491747468

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00186.pdb:::119283238882238870

# PDB_ID:
1DLL

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041018_P00_04_HW_1DP_presat.png:::114624758041376307

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041018_P00_04_HW_1DP_presat.zip:::114624758042159549

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041018_P00_04_HW_1DP_Assigned.png:::116553046484345312

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041018_P00_04_HW_1DP_Presat.png:::116128885026647702

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041018_P00_04_HW_1DP_Presat.zip:::115645410014755164

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
tbl_cnmr:::041018_P00_04_HW_1DC_4.jpg:::114168460009764532

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041018_P00_04_HW_1DC_4.zip:::114168460006597882

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041018_P00_04_HW_1DC_4_Assigned.jpg:::114488041399344230

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041018_P00_04_HW_2DHSQC_7.jpg:::114781209421029864

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041018_P00_04_HW_2DHSQC_7.zip:::114781209425072564

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041018_P00_04_HW_2DHSQC_7_Assigned.jpg:::116127844579116965

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Lactose.gif:::1132732119671876718

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00186_peaks.txt:::1156309603232351175

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Lactose_C.gif:::1132737715150139861

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00186_peaks.txt:::1156310792510535363

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00186L.png:::117555262086091617; Medium Energy:tbl_ms:::HMDB00186M.png:::117555267164375191; High Energy:tbl_ms:::HMDB00186H.png:::117555271031497721

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000065.png:::11689993091255161

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000065.txt:::116899930912538304

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000065.png:::116890825378198763

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000065.txt:::116890825425085878

# Cellular_Location:
Cytoplasm; Extracellular; golgi apparatus; lysosome

# Tissue_Location:
Bladder; Gut; Intestine; Muscle; Platelet; Skin; Spleen

# deuterated:
No

# Biofluid_Location:
Breast Milk

# Concentration_[Normal]:
Breast_Milk	193559.960(57465.853-363531.444)	uM	Adult:>18_yrs_old	N/A	Normal	11787692 
Breast_Milk	161100 +/- 4700	uM	Adult:>18_yrs_old	Female	Normal	16456418 


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Hypolactasia; Insulin Dependent Diabetes Mellitus; Lactase Deficiency, Congenital; Lactose Malabsorption

# Pathway_Names:
Galactose metabolism;Glycerolipid metabolism;Glycosphingolipid metabolism;N-Glycan biosynthesis;Keratan sulfate biosynthesis

# Pathway_Images:
;;;;

# KEGG_Images:
map00052;map00561;map00600;map00510;map00533

# Pathway_Graphs:
;;;;

# Pathway_SBMLs:
;;;;

# Metabolic_Enzyme_1_ID:
5601

# Metabolic_Enzyme_1_Name:
Lactase-phlorizin hydrolase precursor

# Metabolic_Enzyme_1_Synonyms:
Lactase-glycosylceramidase[Includes: Lactase

# Metabolic_Enzyme_1_Gene_Name:
LCT

# Metabolic_Enzyme_1_Protein_Sequence:
>Lactasephlorizin hydrolase precursor
MELSWHVVFIALLSFSCWGSDWESDRNFISTAGPLTNDLLHNLSGLLGDQSSNFVAGDKD
MYVCHQPLPTFLPEYFSSLHASQITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKAL
KTARLQPMVILHHQTLPASTLRRTEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIK
ELPHQESRASQLQTLSDAHRKAYEIYHESYAFQGGKLSVVLRAEDIPELLLEPPISALAQ
DTVDFLSLDLSYECQNEASLRQKLSKLQTIEPKVKVFIFNLKLPDCPSTMKNPASLLFSL
FEAINKDQVLTIGFDINEFLSCSSSSKKSMSCSLTGSLALQPDQQQDHETTDSSPASAYQ
RVWEAFANQSRAERDAFLQDTFPEGFLWGASTGAFNVEGGWAEGGRGVSIWDPRRPLNTT
EGQATLEVASDSYHKVASDVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKL
IDRLQDAGIEPMATLFHWDLPQALQDHGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTF
HEPWVMSYAGYGTGQHPPGISDPGVASFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIV
LNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFVDGDYPATLRTQIQQMNRQCSHPV
AQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQHVNHVWPQT
SSSWIRVVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYIN
EVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTS
IIEKNGFLTKGAKRLLPPNTVNLPSKVRAFTFPSEVPSKAKVVWEKFSSQPKFERDLFYH
GTFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLD
ADLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFH
WDLPQALQDIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFP
PGVKDPGWAPYRIAHTVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDV
EAADRMLQFSLGWFAHPIFRNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRAT
ADVFCLNTYYSRIVQHKTPRLNPPSYEDDQEMAEEEDPSWPSTAMNRAAPWGTRRLLNWI
KEEYGDIPIYITENGVGLTNPNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWSLMD
NFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMPLAREDEFLYGRFPEG
FIWSAASAAYQIEGAWRADGKGLSIWDTFSHTPLRVENDAIGDVACDSYHKIAEDLVTLQ
NLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHWDLPQTL
QDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTAAPGVSNRP
GTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSNQEDVEAARRY
VQFMGGWFAHPIFKNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRINGTYDFFGF
NHYTTVLAYNLNYATAISSFDADRGVASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEY
NDPPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEW
ATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPDPATGPHACLHQPDAGPTI
SPVRQEEVQFLGLMLGTTEAQTALYVLFSLVLLGVCGLAFLSYKYCKRSKQGKTQRSQQE
LSPVSSF

# Metabolic_Enzyme_1_Number_of_Residues:
1927

# Metabolic_Enzyme_1_Molecular_Weight:
218604

# Metabolic_Enzyme_1_Theoretical_pI:
6.30

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  glucosidase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
LPH splits lactose in the small intestine

# Metabolic_Enzyme_1_Pathway:
map00052  Galactose metabolism

# Metabolic_Enzyme_1_Reaction:
lactose + H2O = D-galactose + D-glucose

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00232:Glyco_hydro_1

# Metabolic_Enzyme_1_Signals:
1-19

# Metabolic_Enzyme_1_Transmembrane_Regions:
1883-1901

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.2.1.108;EC 3.2.1.62

# Metabolic_Enzyme_1_GenBank_ID_Protein:
34400

# Metabolic_Enzyme_1_SwissProt_ID:
LPH_HUMAN (P09848)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
LCT

# Metabolic_Enzyme_1_Geneatlas_id:
LCT

# Metabolic_Enzyme_1_hgnc_id:
HGNC:6530

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cell membrane; apical cell membrane; single- pass type I membrane protein. Note=Brush border

# Metabolic_Enzyme_1_Gene_Sequence:
>5784 bp
ATGGAGCTGTCTTGGCATGTAGTCTTTATTGCCCTGCTAAGTTTTTCATGCTGGGGGTCA
GACTGGGAGTCTGATAGAAATTTCATTTCCACCGCTGGTCCTCTAACCAATGACTTGCTG
CACAACCTGAGTGGTCTCCTGGGAGACCAGAGTTCTAACTTTGTAGCAGGGGACAAAGAC
ATGTATGTTTGTCACCAGCCACTGCCCACTTTCCTGCCAGAATACTTCAGCAGTCTCCAT
GCCAGTCAGATCACCCATTATAAGGTATTTCTGTCATGGGCACAGCTCCTCCCAGCAGGA
AGCACCCAGAATCCAGACGAGAAAACAGTGCAGTGCTACCGGCGACTCCTCAAGGCCCTC
AAGACTGCACGGCTTCAGCCCATGGTCATCCTGCACCACCAGACCCTCCCTGCCAGCACC
CTCCGGAGAACCGAAGCCTTTGCTGACCTCTTCGCCGACTATGCCACATTCGCCTTCCAC
TCCTTCGGGGACCTAGTTGGGATCTGGTTCACCTTCAGTGACTTGGAGGAAGTGATCAAG
GAGCTTCCCCACCAGGAATCAAGAGCGTCACAACTCCAGACCCTCAGTGATGCCCACAGA
AAAGCCTATGAGATTTACCACGAAAGCTATGCTTTTCAGGGCGGAAAACTCTCTGTTGTC
CTGCGAGCTGAAGATATCCCGGAGCTCCTGCTAGAACCACCCATATCTGCGCTTGCCCAG
GACACGGTCGATTTCCTCTCTCTTGATTTGTCTTATGAATGCCAAAATGAGGCAAGTCTG
CGGCAGAAGCTGAGTAAATTGCAGACCATTGAGCCAAAAGTGAAAGTTTTCATCTTCAAC
CTAAAACTCCCAGACTGCCCCTCCACCATGAAGAACCCAGCCAGTCTGCTCTTCAGCCTT
TTTGAAGCCATAAATAAAGACCAAGTGCTCACCATTGGGTTTGATATTAATGAGTTTCTG
AGTTGTTCATCAAGTTCCAAGAAAAGCATGTCTTGTTCTCTGACTGGCAGCCTGGCCCTT
CAGCCTGACCAGCAGCAGGACCACGAGACCACGGACTCCTCTCCTGCCTCTGCCTATCAG
AGAGTCTGGGAAGCATTTGCCAATCAGTCCAGAGCGGAAAGGGATGCCTTCCTGCAGGAT
ACTTTCCCTGAAGGCTTCCTCTGGGGTGCCTCCACAGGAGCCTTTAACGTGGAAGGAGGC
TGGGCCGAGGGTGGGAGAGGGGTGAGCATCTGGGATCCACGCAGGCCCCTGAACACCACT
GAGGGCCAAGCGACGCTGGAGGTGGCCAGCGACAGTTACCACAAGGTAGCCTCTGACGTC
GCCCTGCTTTGCGGCCTCCGGGCTCAGGTGTACAAGTTCTCCATCTCCTGGTCCCGGATC
TTCCCCATGGGGCACGGGAGCAGCCCCAGCCTCCCAGGCGTTGCCTACTACAACAAGCTG
ATTGACAGGCTACAGGATGCGGGCATCGAGCCCATGGCCACGCTGTTCCACTGGGACCTG
CCTCAGGCCCTGCAGGATCATGGTGGATGGCAGAATGAGAGCGTGGTGGATGCCTTCCTG
GACTATGCGGCCTTCTGCTTCTCCACATTTGGGGACCGTGTGAAGCTGTGGGTGACCTTC
CATGAGCCGTGGGTGATGAGCTACGCAGGCTATGGCACCGGCCAGCACCCTCCCGGCATC
TCTGACCCAGGAGTGGCCTCTTTTAAGGTGGCTCACTTGGTCCTCAAGGCTCATGCCAGA
ACTTGGCACCACTACAACAGCCATCATCGCCCACAGCAGCAGGGGCACGTGGGCATTGTG
CTGAACTCAGACTGGGCAGAACCCCTGTCTCCAGAGAGGCCTGAGGACCTGAGAGCCTCT
GAGCGCTTCTTGCACTTCATGCTGGGCTGGTTTGCACACCCCGTCTTTGTGGATGGAGAC
TACCCAGCCACCCTGAGGACCCAGATCCAACAGATGAACAGACAGTGCTCCCATCCTGTG
GCTCAACTCCCCGAGTTCACAGAGGCAGAGAAGCAGCTCCTGAAAGGCTCTGCTGATTTT
CTGGGTCTGTCGCATTACACCTCCCGCCTCATCAGCAACGCCCCACAAAACACCTGCATC
CCTAGCTATGATACCATTGGAGGCTTCTCCCAACACGTGAACCATGTGTGGCCCCAGACC
TCATCCTCTTGGATTCGTGTGGTGCCCTGGGGGATAAGGAGGCTGTTGCAGTTTGTATCC
CTGGAATACACAAGAGGAAAAGTTCCAATATACCTTGCCGGGAATGGCATGCCCATAGGG
GAAAGTGAAAATCTCTTTGATGATTCCTTAAGAGTAGACTACTTCAATCAATATATCAAT
GAGGTGCTCAAGGCTATCAAGGAAGACTCTGTGGATGTTCGTTCCTACATTGCTCGTTCC
CTCATTGATGGCTTCGAAGGCCCTTCTGGTTACAGCCAGCGGTTTGGCCTGCACCACGTC
AACTTCAGCGACAGCAGCAAGTCAAGGACTCCCAGGAAATCTGCCTACTTTTTCACTAGC
ATCATAGAAAAGAACGGTTTCCTCACCAAGGGGGCAAAAAGACTGCTACCACCTAATACA
GTAAACCTCCCCTCCAAAGTCAGAGCCTTCACTTTTCCATCTGAGGTGCCCTCCAAGGCT
AAAGTCGTTTGGGAAAAGTTCTCCAGCCAACCCAAGTTCGAAAGAGATTTGTTCTACCAC
GGGACGTTTCGGGATGACTTTCTGTGGGGCGTGTCCTCTTCCGCTTATCAGATTGAAGGC
GCGTGGGATGCCGATGGCAAAGGCCCCAGCATCTGGGATAACTTTACCCACACACCAGGG
AGCAATGTGAAAGACAATGCCACTGGAGACATCGCCTGTGACAGCTATCACCAGCTGGAT
GCCGATCTGAATATGCTCCGAGCTTTGAAGGTGAAGGCCTACCGCTTCTCTATCTCCTGG
TCTCGGATTTTCCCAACTGGGAGAAACAGCTCTATCAACAGTCATGGGGTTGATTATTAC
AACAGGCTGATCAATGGCTTGGTGGCAAGCAACATCTTTCCCATGGTGACATTGTTCCAT
TGGGACCTGCCCCAGGCCCTCCAGGATATCGGAGGCTGGGAGAATCCTGCCTTGATTGAC
TTGTTTGACAGCTACGCAGACTTTTGTTTCCAGACCTTTGGTGATAGAGTCAAGTTTTGG
ATGACTTTTAATGAGCCCATGTACCTGGCATGGCTAGGTTATGGCTCAGGGGAATTTCCC
CCAGGGGTGAAGGACCCAGGCTGGGCACCATATAGGATAGCCCACACCGTCATCAAAGCC
CATGCCAGAGTCTATCACACGTACGATGAGAAATACAGGCAGGAGCAGAAGGGGGTCATC
TCGCTGAGCCTCAGTACACACTGGGCAGAGCCCAAGTCACCAGGGGTCCCCAGAGATGTG
GAAGCCGCTGACCGAATGCTGCAGTTCTCCCTGGGCTGGTTTGCTCACCCCATTTTTAGA
AACGGAGACTATCCTGACACCATGAAGTGGAAAGTGGGGAACAGGAGTGAACTGCAGCAC
TTAGCCACCTCCCGCCTGCCAAGCTTCACTGAGGAAGAGAAGAGGTTCATCAGGGCGACG
GCCGACGTCTTCTGCCTCAACACGTACTACTCCAGAATCGTGCAGCACAAAACACCCAGG
CTAAACCCACCCTCCTACGAAGACGACCAGGAGATGGCTGAGGAGGAGGACCCTTCGTGG
CCTTCCACGGCAATGAACAGAGCTGCGCCCTGGGGGACGCGAAGGCTGCTGAACTGGATC
AAGGAAGAGTATGGTGACATCCCCATTTACATCACCGAAAACGGAGTGGGGCTGACCAAT
CCGAACACGGAGGATACTGATAGGATATTTTACCACAAAACCTACATCAATGAGGCTTTG
AAAGCCTACAGGCTCGATGGTATAGACCTTCGAGGGTATGTCGCCTGGTCTCTGATGGAC
AACTTTGAGTGGCTAAATGGCTACACGGTCAAGTTTGGACTGTACCATGTTGATTTCAAC
AACACGAACAGGCCTCGCACAGCAAGAGCCTCCGCCAGGTACTACACAGAGGTCATTACC
AACAACGGCATGCCACTGGCCAGGGAGGATGAGTTTCTGTACGGACGGTTTCCTGAGGGC
TTCATCTGGAGTGCAGCTTCTGCTGCATATCAGATTGAAGGTGCGTGGAGAGCAGATGGC
AAAGGACTCAGCATTTGGGACACGTTTTCTCACACACCACTGAGGGTTGAGAACGATGCC
ATTGGAGACGTGGCCTGTGACAGTTATCACAAGATTGCTGAGGATCTGGTCACCCTGCAG
AACCTGGGTGTGTCCCACTACCGTTTTTCCATCTCCTGGTCTCGCATCCTCCCTGATGGA
ACCACCAGGTACATCAATGAAGCGGGCCTGAACTACTACGTGAGGCTCATCGATACACTG
CTGGCCGCCAGCATCCAGCCCCAGGTGACCATTTACCACTGGGACCTACCACAGACGCTC
CAAGATGTAGGAGGCTGGGAGAATGAGACCATCGTGCAGCGGTTTAAGGAGTATGCAGAT
GTGCTCTTCCAGAGGCTGGGAGACAAGGTGAAGTTTTGGATCACGTTGAATGAGCCCTTT
GTCATTGCTTACCAGGGCTATGGCTACGGAACAGCAGCTCCAGGAGTCTCCAATAGGCCT
GGCACTGCCCCCTACATTGTTGGCCACAATCTAATAAAGGCTCATGCTGAGGCCTGGCAT
CTGTACAACGATGTGTACCGCGCCAGTCAAGGTGGCGTGATTTCCATCACCATCAGCAGT
GACTGGGCTGAACCCAGAGATCCCTCTAACCAGGAGGATGTGGAGGCAGCCAGGAGATAT
GTTCAGTTCATGGGAGGCTGGTTTGCACATCCTATTTTCAAGAATGGAGATTACAATGAG
GTGATGAAGACGCGGATCCGTGACAGGAGCTTGGCTGCAGGCCTCAACAAGTCTCGGCTG
CCAGAATTTACAGAGAGTGAGAAGAGGAGGATCAACGGCACCTATGACTTTTTTGGGTTC
AATCACTACACCACTGTCCTCGCCTACAACCTCAACTATGCCACTGCCATCTCTTCTTTT
GATGCAGACAGAGGAGTTGCTTCCATCGCAGATCGCTCGTGGCCAGACTCTGGCTCCTTC
TGGCTGAAGATGACGCCTTTTGGCTTCAGGAGGATCCTGAACTGGTTAAAGGAGGAATAC
AATGACCCTCCAATTTATGTCACAGAGAATGGAGTGTCCCAGCGGGAAGAAACAGACCTC
AATGACACTGCAAGGATCTACTACCTTCGGACTTACATCAATGAGGCCCTCAAAGCTGTG
CAGGACAAGGTGGACCTTCGAGGATACACAGTTTGGAGTGCGATGGACAATTTTGAGTGG
GCCACAGGCTTTTCAGAGAGATTTGGTCTGCATTTTGTGAACTACAGTGACCCTTCTCTG
CCAAGGATCCCCAAAGCATCAGCGAAGTTCTACGCCTCTGTGGTCCGATGCAATGGCTTC
CCTGACCCCGCTACAGGGCCTCACGCTTGTCTCCACCAGCCAGATGCTGGACCCACCATC
AGCCCCGTGAGACAGGAGGAGGTGCAGTTCCTGGGGCTAATGCTCGGCACCACAGAAGCA
CAGACAGCTTTGTACGTTCTCTTTTCTCTTGTGCTTCTTGGAGTCTGTGGCTTGGCATTT
CTGTCATACAAGTACTGCAAGCGCTCTAAGCAAGGGAAAACACAACGAAGCCAACAGGAA
TTGAGCCCGGTGTCTTCATTCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X07994

# Metabolic_Enzyme_1_Chromosome_Location:
Not Available

# Metabolic_Enzyme_1_Locus:
Not Available

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
2460343; 1902057

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5608

# Metabolic_Enzyme_2_Name:
Alpha-lactalbumin precursor

# Metabolic_Enzyme_2_Synonyms:
Lactose synthase B protein; Lysozyme- like protein 7

# Metabolic_Enzyme_2_Gene_Name:
LALBA

# Metabolic_Enzyme_2_Protein_Sequence:
>Alphalactalbumin precursor
MRFFVPLFLVGILFPAILAKQFTKCELSQLLKDIDGYGGIALPELICTMFHTSGYDTQAI
VENNESTEYGLFQISNKLWCKSSQVPQSRNICDISCDKFLDDDITDDIMCAKKILDIKGI
DYWLAHKALCTEKLEQWLCEKL

# Metabolic_Enzyme_2_Number_of_Residues:
142

# Metabolic_Enzyme_2_Molecular_Weight:
16225

# Metabolic_Enzyme_2_Theoretical_pI:
4.60

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  UDP-glycosyltransferase activity
Function:  UDP-galactosyltransferase activity
Function:  lactose synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  cellular carbohydrate metabolism
Process:  disaccharide metabolism
Process:  lactose metabolism
Process:  lactose biosynthesis
 ||
>>>
Component:  extracellular region

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins

# Metabolic_Enzyme_2_Pathway:
Not Available

# Metabolic_Enzyme_2_Reaction:
Not Available

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00062:Lys

# Metabolic_Enzyme_2_Signals:
1-19

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.4.1.22

# Metabolic_Enzyme_2_GenBank_ID_Protein:
307104

# Metabolic_Enzyme_2_SwissProt_ID:
LALBA_HUMAN (P00709)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
LALBA

# Metabolic_Enzyme_2_Geneatlas_id:
LALBA

# Metabolic_Enzyme_2_hgnc_id:
HGNC:6480

# Metabolic_Enzyme_2_PDB_ID:
1HML

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_2_Gene_Sequence:
>429 bp
ATGAGGTTCTTTGTCCCTCTGTTCCTGGTGGGCATCCTGTTCCCTGCCATCCTGGCCAAG
CAATTCACAAAATGTGAGCTGTCCCAGCTGCTGAAAGACATAGATGGTTATGGAGGCATC
GCTTTGCCTGAATTGATCTGTACCATGTTTCACACCAGTGGTTATGACACACAAGCCATA
GTTGAAAACAATGAAAGCACGGAATATGGACTCTTCCAGATCAGTAATAAGCTTTGGTGC
AAGAGCAGCCAGGTCCCTCAGTCAAGGAACATCTGTGACATCTCCTGTGACAAGTTCCTG
GATGATGACATTACTGATGACATAATGTGTGCCAAGAAGATCCTGGATATTAAAGGAATT
GACTACTGGTTGGCCCATAAAGCCCTCTGCACTGAGAAGCTGGAACAGTGGCTTTGTGAG
AAGTTGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
J00270

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_2_Locus:
12q13

# Metabolic_Enzyme_2_SNPs:
rs2232565; rs2232566; rs2071380; rs2232569; rs2232570; rs2731088; rs2705170; rs2409044; rs12582811; rs11168643; rs11168642; rs3759149; rs10875835; rs4439559; rs2232567; rs2232568; rs35237195; rs34192861; rs10696670; rs34861458; rs12372110; rs7315024; rs35399476; rs35014829; rs10747550; rs10875833; rs10875834; rs11168635; rs11168636; rs11168637; rs11168638; rs11168639; rs11168640; rs11168641; rs11168644; rs12317119; rs12580814; rs17237094; rs17237198; rs17834022; rs1807757; rs1863543; rs1895997; rs1895998; rs1895999; rs2114321; rs2114322; rs2162318; rs2194984; rs2555002; rs2555003; rs2705117; rs7306166; rs7312017

# Metabolic_Enzyme_2_General_References:
6285305; 2954544; 5049057; 1920433; 8366079; 9537992; 10080897

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6124

# Metabolic_Enzyme_3_Name:
Beta-galactosidase precursor

# Metabolic_Enzyme_3_Synonyms:
Lactase; Acid beta- galactosidase

# Metabolic_Enzyme_3_Gene_Name:
GLB1

# Metabolic_Enzyme_3_Protein_Sequence:
>Betagalactosidase precursor
MPGFLVRILLLLLVLLLLGPTRGLRNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRV
PRFYWKDRLL
KMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVI
LRPGPYICAEWEMGGLPAWLL
EKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGG
PVITVQVENEYGSYFACDFDYLRFLQKRFRHH
LGDDVVLFTTDGAHKTFLKCGALQGLY
TTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQP
HSTIKTEAVASSLYDI
LARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFAL
RNIIQ
KFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGF
VLYRT
TLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLD
LLVENMGRVNYGAYIN
DFKGLVSNLTLSSNILTDWTIFPLDTEDAVRSHLGGWGHRDSG
HHDEAWAHNSSNYTLPAFYMGNFSIPS
GIPDLPQDTFIQFPGWTKGQVWINGFNLGRYW
PARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDD
PELCAVTFVDRPVIGSSVTYD
HPSKPVEKRLMPPPPQKNKDSWLDHV

# Metabolic_Enzyme_3_Number_of_Residues:
677

# Metabolic_Enzyme_3_Molecular_Weight:
76092

# Metabolic_Enzyme_3_Theoretical_pI:
6.55

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  galactosidase activity
Function:  beta-galactosidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  protein complex
Component:  unlocalized protein complex
Component:  beta-galactosidase complex

# Metabolic_Enzyme_3_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans

# Metabolic_Enzyme_3_Pathway:
map00052  Galactose metabolism;
 map00511  N-Glycan degradation;
 map00531  Glycosaminoglycan degradation;
 map00561  Glycerolipid metabolism;
 map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_3_Reaction:
Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01301:Glyco_hydro_35

# Metabolic_Enzyme_3_Signals:
1-23

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.2.1.23

# Metabolic_Enzyme_3_GenBank_ID_Protein:
179401

# Metabolic_Enzyme_3_SwissProt_ID:
BGAL_HUMAN (P16278)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
GLB1

# Metabolic_Enzyme_3_Geneatlas_id:
GLB1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:4298

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_3_Gene_Sequence:
>2034 bp

ATGCCGGGGTTCCTGGTTCGCATCCTCCTTCTGCTGCTGGTTCTGCTGCTTCTGGGCCC
TACGCGCGGCT
TGCGCAATGCCACCCAGAGGATGTTTGAAATTGACTATAGCCGGGACT
CCTTCCTCAAGGATGGCCAGCC
ATTTCGCTACATCTCAGGAAGCATTCACTACTCCCGT
GTGCCCCGCTTCTACTGGAAGGACCGGCTGCTG
AAGATGAAGATGGCTGGGCTGAACGC
CATCCAGACGTATGTGCCCTGGAACTTTCATGAGCCCTGGCCAG
GACAGTACCAGTTTT
CTGAGGACCATGATGTGGAATATTTTCTTCGGCTGGCTCATGAGCTGGGACTGCT
GGTT
ATCCTGAGGCCCGGGCCCTACATCTGTGCAGAGTGGGAAATGGGAGGATTACCTGCTTGG
CTGCTA
GAGAAAGAGTCTATTCTTCTCCGCTCCTCCGACCCAGATTACCTGGCAGCTGT
GGACAAGTGGTTGGGAG
TCCTTCTGCCCAAGATGAAGCCTCTCCTCTATCAGAATGGAG
GGCCAGTTATAACAGTGCAGGTTGAAAA
TGAATATGGCAGCTACTTTGCCTGTGATTTT
GACTACCTGCGCTTCCTGCAGAAGCGCTTTCGCCACCAT
CTGGGGGATGATGTGGTTCT
GTTTACCACTGATGGAGCACATAAAACATTCCTGAAATGTGGGGCCCTGC
AGGGCCTCT
ACACCACGGTGGACTTTGGAACAGGCAGCAACATCACAGATGCTTTCCTAAGCCAGAGGA
A
GTGTGAGCCCAAAGGACCCTTGATCAATTCTGAATTCTATACTGGCTGGCTAGATCAC
TGGGGCCAACCT
CACTCCACAATCAAGACCGAAGCAGTGGCTTCCTCCCTCTATGATAT
ACTTGCCCGTGGGGCGAGTGTGA
ACTTGTACATGTTTATAGGTGGGACCAATTTTGCCT
ATTGGAATGGGGCCAACTCACCCTATGCAGCACA
GCCCACCAGCTACGACTATGATGCC
CCACTGAGTGAGGCTGGGGACCTCACTGAGAAGTATTTTGCTCTG
CGAAACATCATCCA
GAAGTTTGAAAAAGTACCAGAAGGTCCTATCCCTCCATCTACACCAAAGTTTGCAT
ATG
GAAAGGTCACTTTGGAAAAGTTAAAGACAGTGGGAGCAGCTCTGGACATTCTGTGTCCCT
CTGGGCC
CATCAAAAGCCTTTATCCCTTGACATTTATCCAGGTGAAACAGCATTATGGG
TTTGTGCTGTACCGGACA
ACACTTCCTCAAGATTGCAGCAACCCAGCACCTCTCTCTTC
ACCCCTCAATGGAGTCCACGATCGAGCAT
ATGTTGCTGTGGATGGGATCCCCCAGGGAG
TCCTTGAGCGAAACAATGTGATCACTCTGAACATAACAGG
GAAAGCTGGAGCCACTCTG
GACCTTCTGGTAGAGAACATGGGACGTGTGAACTATGGTGCATATATCAAC
GATTTTAA
GGGTTTGGTTTCTAACCTGACTCTCAGTTCCAATATCCTCACGGACTGGACGATCTTTCC
AC
TGGACACTGAGGATGCAGTGCGCAGCCACCTGGGGGGCTGGGGACACCGTGACAGTG
GCCACCATGATGA
AGCCTGGGCCCACAACTCATCCAACTACACGCTCCCGGCCTTTTAT
ATGGGGAACTTCTCCATTCCCAGT
GGGATCCCAGACTTGCCCCAGGACACCTTTATCCA
GTTTCCTGGATGGACCAAGGGCCAGGTCTGGATTA
ATGGCTTTAACCTTGGCCGCTATT
GGCCAGCCCGGGGCCCTCAGTTGACCTTGTTTGTGCCCCAGCACAT
CCTGATGACCTCG
GCCCCAAACACCATCACCGTGCTGGAACTGGAGTGGGCACCCTGCAGCAGTGATGAT
CC
AGAACTATGTGCTGTGACGTTCGTGGACAGGCCAGTTATTGGCTCATCTGTGACCTACGA
TCATCCCT
CCAAACCTGTTGAAAAAAGACTCATGCCCCCACCCCCGCAAAAAAACAAAG
ATTCATGGCTGGACCATGT
ATGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M27507

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_3_Locus:
3p21.33

# Metabolic_Enzyme_3_SNPs:
rs4302331; rs35289681; rs4645101; rs6805519; rs7614585; rs3924695; rs4679075; rs9869052; rs4350874; rs6550204; rs4479543; rs9827863; rs9868526; rs4277638; rs6550200; rs4679074; rs6780220; rs7613051; rs6781225; rs6777787; rs4438612; rs6550203; rs9828592; rs4423716; rs7616912; rs7629880; rs4679082; rs4320035; rs9311003; rs9310999; rs6550202; rs6802807; rs6766207; rs3924696; rs6805766; rs4678613; rs6781531; rs6766191; rs4074708; rs6550191; rs13078132; rs9311001; rs4528891; rs4402881; rs4234266; rs7637435; rs6550205; rs4130167; rs9863198; rs9875798; rs12632196; rs6782510; rs9849898; rs1133253; rs4234262; rs9833676; rs11708012; rs9865921; rs9311002; rs4678868; rs4678660; rs12635761; rs9826234; rs11715310; rs6762132; rs7646283; rs9310998; rs10154834; rs11707667; rs13093517; rs4678657; rs11129544; rs4270461; rs9861960; rs11714207; rs12633904; rs13314478; rs7643224; rs12495572; rs4328758; rs13093698; rs4679076; rs9883177; rs13080709; rs4274702; rs6550199; rs11129542; rs9810375; rs11717007; rs11712996; rs4343578; rs6773715; rs9858362; rs9815409; rs13078515; rs13096312; rs4679077; rs6785135; rs9861316; rs13324134; rs4257495; rs11718295; rs9852589; rs4234267; rs9824270; rs9816051; rs9860199; rs9866187; rs7626612; rs9831065; rs9868815; rs9852081; rs7610177; rs4311175; rs9865232; rs9817993; rs9882717; rs9824218; rs7616228; rs6770187; rs9819337; rs4493381; rs6768988; rs7618005; rs4575834; rs12054351; rs35000357; rs6776757; rs13081593; rs4263242; rs9827128; rs6770614; rs13078446; rs9883376; rs4998983; rs11706136; rs9830701; rs4678652; rs7628722; rs4269037; rs6783481; rs7610270; rs4491851; rs13094148; rs6769803; rs9845011; rs12491500; rs6805872; rs9851902; rs9860184; rs9754700; rs6770682; rs9838286; rs9840748; rs9810955; rs9829197; rs11129543; rs12490111; rs4679097; rs9872578; rs4558698; rs9814670; rs9841000; rs34173901; rs4456812; rs9858291; rs11924625; rs4383462; rs4630893; rs6782297; rs4583587; rs4678644; rs6786613; rs7610916; rs7650543; rs11720449; rs4547648; rs9865113; rs11707205; rs7645956; rs34103134; rs4428129; rs11927929; rs4371463; rs13079353; rs4234264; rs11713054; rs6769787; rs9849213; rs9851459; rs12633200; rs9817393; rs6782318; rs9880004; rs9863331; rs12167; rs7643313; rs4678523; rs4678524; rs1803198; rs13073546; rs1803199; rs34421970; rs1803200; rs34204221; rs6776436; rs35360222; rs35516563; rs35949170; rs35217324; rs34064757; rs9681623; rs35066652; rs9879174; rs28457681; rs35366996; rs12636380; rs35546490; rs4411834; rs34170794; rs34840292; rs11706680; rs35079906; rs35567563; rs35096418; rs34190372; rs34267899; rs9835090; rs34542942; rs28564715; rs34783720; rs35299531; rs28752078; rs35609083; rs4404396; rs10596366; rs36061528; rs35625458; rs6550190; rs4678642; rs35791447; rs35543972; rs10702620; rs7612742; rs11387959; rs9875140; rs9858992; rs28538948; rs4472006; rs34081225; rs35480293; rs11443960; rs34301631; rs34629244; rs9836304; rs4678941; rs9825789; rs11927839; rs35111870; rs35849739; rs34459243; rs6767833; rs7431645; rs10683710; rs28488329; rs9825335; rs35781117; rs9872225; rs34491679; rs13077125; rs9858364; rs11342344; rs35553546; rs35894066; rs10559091; rs35313892; rs6800001; rs13079744; rs13062239; rs10662168; rs6772595; rs13059918; rs34558646; rs28615536; rs11303788; rs10679653; rs36181668; rs35688004; rs11414853; rs7610165; rs35269925; rs11348689; rs34388197; rs11459888; rs9852362; rs4678643; rs4130168; rs11328798; rs7621255; rs11276167; rs11915291; rs28727973; rs13092698; rs34500490; rs36036446; rs7610931; rs35201739; rs6785862; rs11428956; rs11385614; rs4234263; rs7619312; rs11717735; rs34139339; rs34827860; rs6776437; rs6770268; rs12054117; rs34097913; rs11416783; rs35555652; rs36140454; rs9848784; rs10613912; rs35419837; rs35291321; rs4613407; rs34772446; rs35570272; rs7650438; rs6792048; rs11289119; rs11707202; rs7646643; rs35879433; rs35844867; rs28420683; rs28617702; rs34103242; rs35684962; rs34958264; rs9845695; rs34986791; rs35533674; rs34652262; rs7628609; rs35507451; rs35777526; rs35835691; rs4298001; rs35847345; rs35580094; rs28372666; rs34648323; rs13098058; rs9865342; rs34547154; rs35399363; rs35548830; rs9811260; rs34925031; rs4130166; rs10661628; rs9849872; rs35026670; rs13072499; rs34482863; rs4447709; rs4508727; rs12487241; rs9831194; rs13082782; rs10529787; rs13314904; rs4234234; rs9873651; rs5847772; rs11423270; rs9850839; rs10528005; rs35809982; rs9838124; rs4678849; rs11711396; rs11715480; rs11718846; rs11914868; rs12635828; rs4075736; rs4578976; rs4678677; rs4678774; rs6769735; rs6793913; rs7612234; rs7614776; rs9860567

# Metabolic_Enzyme_3_General_References:
2511208; 2111707; 3143362; 10841810; 10571006; 1928092; 1909089; 1907800; 1487238; 8213816; 8198123; 7586649; 9203065; 12393180; 10338095; 10839995; 10737981; 11511921

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5614

# Metabolic_Enzyme_4_Name:
Beta-1,4-galactosyltransferase 1

# Metabolic_Enzyme_4_Synonyms:
Beta-1,4-GalTase 1; Beta4Gal-T1; b4Gal-T1; UDP-galactose:beta-N-acetylglucosamine beta- 1,4-galactosyltransferase 1; UDP-Gal:beta-GlcNAc beta-1,4- galactosyltransferase 1[Includes: Lactose synthase A protein; Nal synthetase; Beta-N-acetylglucosaminylglycopeptide beta-1,4- galactosyltransferase

# Metabolic_Enzyme_4_Gene_Name:
B4GALT1

# Metabolic_Enzyme_4_Protein_Sequence:
>Beta1,4galactosyltransferase 1
MRLREPLLSGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLSRLPQLVGVSTPL
QGGSNSAAAIGQSSGELRTGGARPPPPLGASSQPRPGGDSSPVVDSGPGPASNLTSVPVP
HTTALSLPACPEESPLLVGPMLIEFNMPVDLELVAKQNPNVKMGGRYAPRDCVSPHKVAI
IIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQAGDTIFNRAKLLNVGFQEALKDYD
YTCFVFSDVDLIPMNDHNAYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLTI
NGFPNNYWGWGGEDDDIFNRLVFRGMSISRPNAVVGRCRMIRHSRDKKNEPNPQRFDRIA
HTKETMLSDGLNSLTYQVLDVQRYPLYTQITVDIGTPS

# Metabolic_Enzyme_4_Number_of_Residues:
398

# Metabolic_Enzyme_4_Molecular_Weight:
43921

# Metabolic_Enzyme_4_Theoretical_pI:
8.77

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix

# Metabolic_Enzyme_4_Pathway:
map00510  N-Glycan biosynthesis;
 map00533  Keratan sulfate biosynthesis

# Metabolic_Enzyme_4_Reaction:
UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF02709:Galactosyl_T_2

# Metabolic_Enzyme_4_Signals:
1-37

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.4.1.22;EC 2.4.1.90;E

# Metabolic_Enzyme_4_GenBank_ID_Protein:
29424

# Metabolic_Enzyme_4_SwissProt_ID:
B4GT1_HUMAN (P15291)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
B4GALT1

# Metabolic_Enzyme_4_Geneatlas_id:
B4GALT1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:924

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Isoform Long:Golgi apparatus; Golgi stack; Golgi stack membrane; single-pass type II membrane protein. Cell membrane; single-pass type II membrane protein. Cell surface. Isoform Short:Golgi apparatus; Golgi stack; Golgi stack membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Isoforms Long and Short are found in trans cisternae of Golgi. A soluble form, found in body fluids, is produced by proteolytic processing, is present in body fluids

# Metabolic_Enzyme_4_Gene_Sequence:
>1203 bp
ATGAGGCTTCGGGAGCCGCTCCTGAGCGGCGCCGCGATGCCAGGCGCGTCCCTACAGCGG
GCCTGCCGCCTGCTCGTGGCCGTCTGCGCTCTGCACCTTGGCGTCACCCTCGTTTACTAC
CTGGCTGGCCGCGACCTGAGCCGCCTGCCCCAACTGGTCGGAGTCTCCACACCGCTGCAG
GGCGGCTCGAACAGTGCCGCCGCCATCGGGCAGTCCTCCGGGGAGCTCCGGACCGGAGGG
GCCCGGCCGCCGCCTCCTCTAGGCGCCTCCTCCCAGCCGCGCCCGGGTGGCGACTCCAGC
CCAGTCGTGGATTCTGGCCCTGGCCCCGCTAGCAACTTGACCTCGGTCCCAGTGCCCCAC
ACCACCGCACTGTCGCTGCCCGCCTGCCCTGAGGAGTCCCCGCTGCTTGTGGGCCCCATG
CTGATTGAGTTTAACATGCCTGTGGACCTGGAGCTCGTGGCAAAGCAGAACCCAAATGTG
AAGATGGGCGGCCGCTATGCCCCCAGGGACTGCGTCTCTCCTCACAAAGTGGCCATCATC
ATTCCATTCCGCAACCGGCAGGAGCACCTCAAGTACTGGCTATATTATTTGCACCCAGTC
CTGCAGCGCCAGCAGCTGGACTATGGCATCTATGGCATCTATGTTATCAACCAGGCGGGA
GACACTATATTCAATCGTGCTAAGCTCCTCAATGTTGGCTTTCAAGAAGCCTTGAAGGAC
TATGACTACACCTGCTTTGTGTTTAGTGACGTGGACCTCATCCCAATGAATGACCATAAT
GCGTACAGGTGTTTTTCACAGCCACGGCACATTTCCGTTGCAATGGATAAGTTTGGATTC
AGCCTACCTTATGTTCAGTATTTTGGAGGTGTCTCTGCTCTAAGTAAACAACAGTTTCTA
ACCATCAATGGATTTCCTAATAATTATTGGGGCTGGGGAGGAGAAGATGATGACATTTTT
AACAGATTAGTTTTTAGAGGCATGTCTATATCTCGCCCAAATGCTGTGGTCGGGAGGTGT
CGCATGATCCGCCACTCAAGAGACAAAAAAAATGAACCCAATCCTCAGAGGTTTGACCGA
ATTGCACACACAAAGGAGACAATGCTCTCTGATGGTTTGAACTCACTCACCTACCAGGTG
CTGGATGTACAGAGATACCCATTGTATACCCAAATCACAGTGGACATCGGGACACCGAGC
TAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
X14085

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_4_Locus:
9p13

# Metabolic_Enzyme_4_SNPs:
rs1065764; rs1065765; rs7019896; rs7019909; rs869; rs10971412; rs17326497; rs10412; rs16918998; rs17247945; rs17326539; rs16918999; rs13289751; rs1018; rs7041783; rs1803716; rs16918997; rs1411609; rs7849148; rs913214; rs10758189; rs3780490; rs10738906; rs10971419; rs3780487; rs7864705; rs10971424; rs2031902; rs7865745; rs10813957; rs7036812; rs10124479; rs10113903; rs3780480; rs10217267; rs10738907; rs2770807; rs10971418; rs1328898; rs4879666; rs4584234; rs2209948; rs10813950; rs3780499; rs3780481; rs1969977; rs3818593; rs10117038; rs7029897; rs1328899; rs7873903; rs3824458; rs10758194; rs1969976; rs3780484; rs12379501; rs3780495; rs3824459; rs10116966; rs4879665; rs3780488; rs10758192; rs10121987; rs7868781; rs2183124; rs6476400; rs10813954; rs3780485; rs6476399; rs3780489; rs3780491; rs10738905; rs10813958; rs7850878; rs7850730; rs959749; rs10758188; rs10738909; rs12683460; rs11792560; rs10813956; rs7873077; rs7868653; rs2376766; rs7859454; rs10758191; rs10813955; rs7043474; rs10813959; rs6476402; rs17327324; rs7020500; rs2774272; rs12346594; rs1571436; rs4878525; rs10511909; rs7045547; rs7028949; rs3780494; rs10758190; rs6476398; rs10971414; rs17327015; rs2567408; rs10813952; rs10813951; rs10971426; rs7868663; rs7467148; rs12343079; rs10813953; rs10971425; rs3780486; rs10971430; rs11793020; rs13283483; rs10114471; rs10971417; rs12554995; rs958532; rs3780483; rs1060534; rs2770808; rs7851385; rs7873182; rs10971415; rs10813948; rs12342831; rs7868990; rs10971422; rs10813949; rs6476401; rs7865362; rs10217770; rs12554628; rs605915; rs7037398; rs3758273; rs9169; rs1064905; rs1142254; rs1064906; rs1064910; rs1064909; rs35952183; rs10607134; rs3841451; rs1803717; rs11548671; rs1064950; rs41274019; rs41316025; rs7041909; rs41274017; rs41274023; rs41303661; rs35504729; rs41274021; rs34791389; rs13764; rs35436284; rs34856798; rs10453199; rs10971420; rs7874095; rs3837268; rs35478918; rs3780493; rs13298273; rs34636838; rs35457360; rs7863963; rs11291171; rs13299659; rs34367010; rs34420698; rs10971429; rs35406954; rs34302260; rs10971433; rs11290421; rs35401344; rs2567412; rs36007663; rs35937194; rs11793894; rs12378256; rs660497; rs28429368; rs3837267; rs1072601; rs3780478; rs12376786; rs13296530; rs33951459; rs12552871; rs11449568; rs1360056; rs2481060; rs35102741; rs10813947; rs12685679; rs7850651; rs11793877; rs11369539; rs36047322; rs34402268; rs12350201; rs10453200; rs35177345; rs2889461; rs35233105; rs10701535; rs28389469; rs34066440; rs13301084; rs10570814; rs35065587; rs12375544; rs2067749; rs1753855; rs34433922; rs11414746; rs12352863; rs35653104; rs10971427; rs1887876; rs13296176; rs35113991; rs34931533; rs3780479; rs2435973; rs13298728; rs35354911; rs13289149; rs4878526; rs10758193; rs913215; rs34813509; rs34018955; rs5897535; rs34554920; rs10971421; rs34653816; rs1410774; rs35909904; rs34914931; rs3065241; rs34804483; rs35058735; rs10116935; rs36205834; rs10574717; rs35559504; rs36085848; rs34243341; rs6150980; rs10971431; rs11795362; rs865515; rs34566644; rs13297246; rs13284257; rs35876633; rs1137643; rs35799631; rs34553800; rs34778677; rs3065244; rs1137642; rs35494749; rs3780492; rs34047756; rs10121006; rs864925; rs36044755; rs35729023; rs10633991; rs34888597; rs35507104; rs5897536; rs34919692; rs35884423; rs13290301; rs10971428; rs13287923; rs10971416; rs13287775; rs10971411; rs13296330; rs13287724; rs10971434; rs7850948; rs1013215; rs1013216; rs1013217; rs10738908; rs10758186; rs10813946; rs10971409; rs11787896; rs11792978; rs11998760; rs13285029; rs13288792; rs13297389; rs1556253; rs1556254; rs1887877; rs2481061; rs2481062; rs2770809; rs28612947; rs28645680; rs35172105; rs544723; rs546688; rs581450; rs589733; rs594988; rs750590; rs750591; rs750592; rs7860416; rs7863609; rs830089; rs874200; rs874202; rs943929

# Metabolic_Enzyme_4_General_References:
3144273; 2124683; 1903938; 1384956; 7579794; 7540104; 3094506; 3091013; 2120039; 1714903; 7744867; 10580128

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5607

# Metabolic_Enzyme_5_Name:
Beta-1,4-galactosyltransferase 2

# Metabolic_Enzyme_5_Synonyms:
Beta-1,4-GalTase 2; Beta4Gal-T2; b4Gal-T2; UDP-galactose:beta-N-acetylglucosamine beta- 1,4-galactosyltransferase 2; UDP-Gal:beta-GlcNAc beta-1,4- galactosyltransferase 2[Includes: Lactose synthase A protein; Nal synthetase; Beta-N-acetylglucosaminylglycopeptide beta-1,4- galactosyltransferase

# Metabolic_Enzyme_5_Gene_Name:
B4GALT2

# Metabolic_Enzyme_5_Protein_Sequence:
>Beta1,4galactosyltransferase 2
MSRLLGGTLERVCKAVLLLCLLHFLVAVILYFDVYAQHLAFFSRFSARGPAHALHPAASS
SSSSSNCSRPNATASSSGLPEVPSALPGPTAPTLPPCPDSPPGLVGRLLIEFTSPMPLER
VQRENPGVLMGGRYTPPDCTPAQTVAVIIPFRHREHHLRYWLHYLHPILRRQRLRYGVYV
INQHGEDTFNRAKLLNVGFLEALKEDAAYDCFIFSDVDLVPMDDRNLYRCGDQPRHFAIA
MDKFGFRLPYAGYFGGVSGLSKAQFLRINGFPNEYWGWGGEDDDIFNRISLTGMKISRPD
IRIGRYRMIKHDRDKHNEPNPQRFTKIQNTKLTMKRDGIGSVRYQVLEVSRQPLFTNITV
DIGRPPSWPPRG

# Metabolic_Enzyme_5_Number_of_Residues:
372

# Metabolic_Enzyme_5_Molecular_Weight:
41973

# Metabolic_Enzyme_5_Theoretical_pI:
9.66

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose

# Metabolic_Enzyme_5_Pathway:
map00510  N-Glycan biosynthesis;
 map00533  Keratan sulfate biosynthesis

# Metabolic_Enzyme_5_Reaction:
UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF02709:Galactosyl_T_2

# Metabolic_Enzyme_5_Signals:
1-27

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.4.1.22;EC 2.4.1.90;E

# Metabolic_Enzyme_5_GenBank_ID_Protein:
2995442

# Metabolic_Enzyme_5_SwissProt_ID:
B4GT2_HUMAN (O60909)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
B4GALT2

# Metabolic_Enzyme_5_Geneatlas_id:
B4GALT2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:925

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Golgi apparatus; Golgi stack; Golgi stack membrane; single-pass type II membrane protein. Note=Trans cisternae of Golgi stack

# Metabolic_Enzyme_5_Gene_Sequence:
>1119 bp
ATGAGCAGACTGCTGGGGGGGACGCTGGAGCGCGTCTGCAAGGCTGTGCTCCTTCTCTGC
CTGCTGCACTTCCTCGTGGCCGTCATCCTCTACTTTGACGTCTACGCCCAGCACCTGGCC
TTCTTCAGCCGCTTCAGTGCCCGAGGCCCTGCCCATGCCCTCCACCCAGCTGCTAGCAGC
AGCAGCAGCAGCAGCAACTGCTCCCGGCCCAACGCCACCGCCTCTAGCTCCGGGCTCCCT
GAGGTCCCCAGTGCCCTGCCCGGTCCCACGGCTCCCACGCTGCCACCCTGTCCTGACTCG
CCACCTGGTCTTGTGGGCAGACTGCTGATCGAGTTCACCTCACCCATGCCCCTGGAGCGG
GTGCAGAGGGAGAACCCAGGCGTGCTCATGGGCGGCCGATACACACCGCCCGACTGCACC
CCAGCCCAGACGGTGGCGGTCATCATCCCCTTTAGACACCGGGAACACCACCTGCGCTAC
TGGCTCCACTATCTACACCCCATCTTGAGGCGGCAGCGGCTGCGCTACGGCGTCTATGTC
ATCAACCAGCATGGTGAGGACACCTTCAACCGGGCCAAGCTGCTTAACGTGGGCTTCCTA
GAGGCGCTGAAGGAGGATGCCGCCTATGACTGCTTCATCTTCAGCGATGTGGACCTGGTC
CCCATGGATGACCGCAACCTATACCGCTGCGGCGACCAACCCCGCCACTTTGCCATTGCC
ATGGACAAGTTTGGCTTCCGGCTTCCCTATGCTGGCTACTTTGGAGGTGTGTCAGGCCTG
AGTAAGGCTCAGTTTCTGAGAATCAATGGCTTCCCCAATGAGTACTGGGGCTGGGGTGGC
GAGGATGATGACATCTTCAACCGGATCTCCCTGACTGGGATGAAGATCTCACGCCCAGAC
ATCCGAATCGGCCGCTACCGCATGATCAAGCACGACCGCGACAAGCATAACGAACCTAAC
CCTCAGAGGTTTACCAAGATTCAAAACACGAAGCTGACCATGAAGCGGGACGGCATTGGG
TCAGTGCGGTACCAGGTCTTGGAGGTGTCTCGGCAACCACTCTTCACCAATATCACAGTG
GACATTGGGCGGCCTCCGTCGTGGCCCCCTCGGGGCTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
Y12510

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_5_Locus:
1p34-p33

# Metabolic_Enzyme_5_SNPs:
rs1859728; rs1061781; rs2486005; rs2231280; rs2486006; rs2486003; rs869896; rs2231283; rs11577031; rs12738136; rs2286244; rs11577574; rs4567315; rs3791122; rs882961; rs11544735; rs2353008; rs1061780; rs41303407; rs11544734; rs35324782; rs3762423; rs12752663; rs2231281; rs2231279; rs2993619; rs730915; rs2486004; rs34803765; rs28578348; rs2231282; rs34161254; rs34309153; rs28379629; rs12031636; rs34951027; rs730916; rs35671171; rs34690835; rs34640774; rs12030702; rs41270399; rs13374291; rs34413382; rs11804947; rs11580847; rs12410334; rs12563522; rs12757070; rs1296541; rs14084; rs14785; rs16831527; rs2231285; rs2248253; rs2248632; rs2286241; rs2286242; rs2286243; rs2286245; rs2286246; rs2301983; rs2428953; rs2428954; rs2486008; rs35181336; rs35286676; rs35655174; rs35904809; rs36042542; rs3791124; rs3791125; rs4660761; rs6671811; rs7161; rs7528392; rs7555; rs783308; rs803619; rs8494

# Metabolic_Enzyme_5_General_References:
9405390; 9597550; 11588157; 10580128

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
8825

# Metabolic_Enzyme_6_Name:
Lysosomal protective protein precursor

# Metabolic_Enzyme_6_Synonyms:
Cathepsin A; Carboxypeptidase C; Protective protein for beta-galactosidase[Contains: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain]

# Metabolic_Enzyme_6_Gene_Name:
CTSA

# Metabolic_Enzyme_6_Protein_Sequence:
>Lysosomal protective protein precursor
MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSK
HLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLI
ANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYA
GIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHC
CSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQD
LGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWD
MCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKME
VQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY


# Metabolic_Enzyme_6_Number_of_Residues:
480

# Metabolic_Enzyme_6_Molecular_Weight:
54467

# Metabolic_Enzyme_6_Theoretical_pI:
6.59

# Metabolic_Enzyme_6_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  exopeptidase activity
Function:  carboxypeptidase activity
Function:  serine carboxypeptidase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Amino acid transport and metabolism

# Metabolic_Enzyme_6_Specific_Function:
Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins

# Metabolic_Enzyme_6_Pathway:
Not Available

# Metabolic_Enzyme_6_Reaction:
Release of a C-terminal amino acid with broad specificity

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00450:Peptidase_S10

# Metabolic_Enzyme_6_Signals:
1-28

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.4.16.5

# Metabolic_Enzyme_6_GenBank_ID_Protein:
190283

# Metabolic_Enzyme_6_SwissProt_ID:
PPGB_HUMAN (P10619)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
CTSA

# Metabolic_Enzyme_6_Geneatlas_id:
CTSA

# Metabolic_Enzyme_6_hgnc_id:
HGNC:9251

# Metabolic_Enzyme_6_PDB_ID:
1IVY

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_6_Gene_Sequence:
>1443 bp
ATGATCCGAGCCGCGCCGCCGCCGCTGTTCCTGCTGCTGCTGCTGCTGCTGCTGCTAGTG
TCCTGGGCGTCCCGAGGCGAGGCAGCCCCCGACCAGGACGAGATCCAGCGCCTCCCCGGG
CTGGCCAAGCAGCCGTCTTTCCGCCAGTACTCCGGCTACCTCAAAAGCTCCGGCTCCAAG
CACCTCCACTACTGGTTTGTGGAGTCCCAGAAGGATCCCGAGAACAGCCCTGTGGTGCTT
TGGCTCAATGGGGGTCCCGGCTGCAGCTCACTAGATGGGCTCCTCACAGAGCATGGCCCC
TTCCTGGTCCAGCCAGATGGTGTCACCCTGGAGTACAACCCCTATTCTTGGAATCTGATT
GCCAATGTGTTATACCTGGAGTCCCCAGCTGGGGTGGGCTTCTCCTACTCCGATGACAAG
TTTTATGCAACTAATGACACTGAGGTCGCCCAGAGCAATTTTGAGGCCCTTCAAGATTTC
TTCCGCCTCTTTCCGGAGTACAAGAACAACAAACTTTTCCTGACCGGGGAGAGCTATGCT
GGCATCTACATCCCCACCCTGGCCGTGCTGGTCATGCAGGATCCCAGCATGAACCTTCAG
GGGCTGGCTGTGGGCAATGGACTCTCCTCCTATGAGCAGAATGACAACTCCCTGGTCTAC
TTTGCCTACTACCATGGCCTTCTGGGGAACAGGCTTTGGTCTTCTCTCCAGACCCACTGC
TGCTCTCAAAACAAGTGTAACTTCTATGACAACAAAGACCTGGAATGCGTGACCAATCTT
CAGGAAGTGGCCCGCATCGTGGGCAACTCTGGCCTCAACATCTACAATCTCTATGCCCCG
TGTGCTGGAGGGGTGCCCAGCCATTTTAGGTATGAGAAGGACACTGTTGTGGTCCAGGAT
TTGGGCAACATCTTCACTCGCCTGCCACTCAAGCGGATGTGGCATCAGGCACTGCTGCGC
TCAGGGGATAAAGTGCGCATGGACCCCCCCTGCACCAACACAACAGCTGCTTCCACCTAC
CTCAACAACCCGTACGTGCGGAAGGCCCTCAACATCCCGGAGCAGCTGCCACAATGGGAC
ATGTGCAACTTTCTGGTAAACTTACAGTACCGCCGTCTCTACCGAAGCATGAACTCCCAG
TATCTGAAGCTGCTTAGCTCACAGAAATACCAGATCCTATTATATAATGGAGATGTAGAC
ATGGCCTGCAATTTCATGGGGGATGAGTGGTTTGTGGATTCCCTCAACCAGAAGATGGAG
GTGCAGCGCCGGCCCTGGTTAGTGAAGTACGGGGACAGCGGGGAGCAGATTGCCGGCTTC
GTGAAGGAGTTCTCCCACATCGCCTTTCTCACGATCAAGGGCGCCGGCCACATGGTTCCC
ACCGACAAGCCCCTCGCTGCCTTCACCATGTTCTCCCGCTTCCTGAACAAGCAGCCATAC
TGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M22960

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_6_Locus:
20q13.1

# Metabolic_Enzyme_6_SNPs:
rs25649; rs4608591; rs7270170; rs11569665; rs4810476; rs742034; rs11569663; rs6104390; rs6094225; rs11569662; rs11569664; rs11569667; rs2075961; rs2075962; rs2075963; rs11538053; rs11484230; rs6094226; rs5841612; rs33947058; rs34656072; rs3215446; rs6130962; rs34800818; rs34590242; rs6130963; rs11468785; rs6094227; rs11698406; rs6124756; rs34300421; rs11480920; rs396980; rs11569666; rs35404688; rs5841610; rs5841611; rs35814654; rs11482387; rs1056929; rs11086984; rs11086985; rs11569644; rs11569645; rs11569646; rs11569647; rs11569649; rs11569651; rs11569652; rs11569661; rs11569674; rs11569675; rs12481109; rs1736493; rs1804161; rs1804212; rs1804213; rs2077056; rs2664568; rs2664590; rs2868362; rs34017227; rs34942730; rs35165640; rs35342327; rs35972756; rs3746500; rs3817731; rs3827040; rs4812974; rs4942; rs553359; rs6017711; rs6032575; rs6032577; rs6032580; rs6065903; rs6065904; rs6073942; rs6073943; rs6073945; rs6073946; rs6073947; rs6073951; rs6073952; rs6094224; rs6104386; rs6104388; rs6104389; rs6104393; rs7268221; rs742035

# Metabolic_Enzyme_6_General_References:
3136930; 11780052; 1694176; 12665801; 1907282; 8591035; 1756715; 8514852

# Metabolic_Enzyme_6_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7556

# Macromolecular_Interacting_Partner_1_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_1_Signals:
1-18

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_1_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_1_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_1_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_1_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_1_References:
14608620; 15264873; 16542374

# Macromolecular_Interacting_Partner_2_ID:
7671

# Macromolecular_Interacting_Partner_2_Name:
Alpha-S1-casein precursor [Contains: Casoxin-D]

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
CSN1S1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>AlphaS1casein precursor Contains: Casoxin
DMRLLILTCLVAVALARPKLPLRYPERLQNPSESSEPIPLESREEYMNGMNRQRNILREK
QTDEIKDTRNESTQNCVVAEPEKMESSISSSSEEMSLSKCAEQFCRLNEYNQLQLQAAHA
QEQIRRMNENSHVQVPFQQLNQLAAYPYAVWYYPQIMQYVPFPPFSDISNPTAHENYEKN
NVMLQW

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
185

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
21672

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.08

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Signals:
1-15

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
854086

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
CASA1_HUMAN (P47710)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
CSN1S1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
CSN1S1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:2445

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>558 bp
ATGAGGCTTCTCATTCTCACCTGTCTTGTGGCTGTTGCTCTTGCCAGGCCTAAACTTCCT
CTTAGATACCCAGAACGCCTTCAGAATCCATCAGAGAGCAGTGAGCCTATACCATTAGAA
TCAAGAGAGGAATACATGAATGGTATGAACAGGCAGAGAAACATTCTGAGAGAAAAACAG
ACTGATGAAATCAAGGATACTAGGAATGAGTCTACTCAGAACTGTGTTGTGGCAGAGCCT
GAGAAGATGGAATCCAGCATCAGTTCATCGAGTGAGGAAATGTCTCTCAGTAAGTGTGCG
GAACAGTTTTGTAGACTGAACGAATACAACCAACTTCAGCTGCAAGCTGCCCATGCCCAG
GAGCAAATTCGCAGAATGAATGAAAACAGCCATGTCCAAGTGCCTTTCCAGCAGCTCAAC
CAACTTGCTGCCTACCCCTATGCTGTTTGGTACTATCCACAAATCATGCAGTATGTTCCT
TTCCCACCGTTTTCCGACATCTCCAATCCCACTGCTCATGAAAATTATGAAAAAAATAAC
GTCATGCTACAGTGGTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
X78416

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_2_Locus:
4q21.1

# Macromolecular_Interacting_Partner_2_SNPs:
rs10030475; rs1237375; rs2291531; rs2306995; rs1220853; rs2029572; rs17146477; rs1388353; rs1220860; rs1220858; rs1220859; rs2279526; rs17629671; rs2637803; rs9994880; rs3775766; rs1231466; rs17146476; rs2306994; rs12499547; rs17696920; rs17146475; rs10022914; rs10024477; rs12503280; rs1529038; rs1220854; rs1220841; rs1220842; rs17696835; rs1220843; rs34698344; rs35936840; rs28563121; rs10029240; rs962689; rs6148504; rs34493157; rs13115383; rs35000195; rs28633589; rs7436100; rs10002549; rs36026498; rs3736267; rs3736268; rs34713531; rs9992853; rs34572389; rs28388277; rs35005404; rs28633873; rs1220857; rs3822170; rs2877505; rs12499478; rs33928842; rs10028221; rs36213128; rs2222793; rs10026137; rs5859206; rs3756137; rs3078677; rs34788552; rs10032658; rs9994675; rs5859205; rs1220855; rs10011226; rs34898191; rs28592911; rs5859204; rs1220856; rs10030869; rs10030691; rs33916414; rs28478637; rs9998575; rs10009308; rs28583244; rs10008887; rs10017650; rs10020367; rs1002081; rs1002082; rs10155315; rs1220849; rs1220861; rs1220862; rs13113735; rs1388354; rs1491429; rs1491430; rs17147885; rs17697310; rs1844828; rs1919597; rs2331853; rs2637815; rs2637816; rs2734570; rs4568298; rs4694257; rs7680177; rs9654357; rs9884504; rs999694

# Macromolecular_Interacting_Partner_2_General_References:
7619062; 7749638; 9050925

# Macromolecular_Interacting_Partner_2_References:
16403887; 16434457

# Macromolecular_Interacting_Partner_3_ID:
7921

# Macromolecular_Interacting_Partner_3_Name:
Galectin-1

# Macromolecular_Interacting_Partner_3_Synonyms:
Lectin galactoside-binding soluble 1; Beta-galactoside- binding lectin L-14-I; Lactose-binding lectin 1; S-Lac lectin 1; Galaptin; 14 kDa lectin; HPL; HBL; Putative MAPK-activating protein MP12

# Macromolecular_Interacting_Partner_3_Gene_Name:
LGALS1

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Galectin1
MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIV
CNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINY
MAADGDFKIKCVAFD

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
135

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
14716

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
5.15

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
May regulate cell apoptosis and cell differentiation. Binds beta-galactoside. Binds CD45, CD3 and CD4. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00337:Gal-bind_lectin

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
34343

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
LEG1_HUMAN (P09382)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
LGALS1

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
LGALS1

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:6561

# Macromolecular_Interacting_Partner_3_PDB_ID:
1GZW

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>408 bp
ATGGCTTGTGGTCTGGTCGCCAGCAACCTGAATCTCAAACCTGGAGAGTGCCTTCGAGTG
CGAGGCGAGGTGGCTCCTGACGCTAAGAGCTTCGTGCTGAACCTGGGCAAAGACAGCAAC
AACCTGTGCCTGCACTTCAACCCTCGCTTCAACGCCCACGGCGACGCCAACACCATCGTG
TGCAACAGCAAGGACGGCGGGGCCTGGGGGACCGAGCAGCGGGAGGCTGTCTTTCCCTTC
CAGCCTGGAAGTGTTGCAGAGGTGTGCATCACCTTCGACCAGGCCAACCTGACCGTCAAG
CTGCCAGATGGATACGAATTCAAGTTCCCCAACCGCCTCAACCTGGAGGCCATCAACTAC
ATGGCAGCTGACGGTGACTTCAAGATCAAATGTGTGGCCTTTGACTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
X14829

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_3_Locus:
22q13.1

# Macromolecular_Interacting_Partner_3_SNPs:
rs9622680; rs9622682; rs12167604; rs4820294; rs4820293; rs929039; rs2071769; rs11539852; rs11539846; rs4887; rs11539856; rs3208174; rs11539850; rs11704758; rs11539847; rs1803902; rs4888; rs35767287; rs11539857; rs12251; rs11539854; rs34671258; rs35297059; rs12157867; rs9917591; rs9619701; rs9622681; rs12172389; rs34806296; rs5845352; rs3985986; rs9610829; rs13057866; rs7287759; rs35411985; rs41283239; rs35530306; rs34195652; rs11914203; rs13055131; rs2899292; rs3177075; rs4820295; rs5756764; rs6000861; rs6000862; rs713835; rs739139; rs743837; rs762990

# Macromolecular_Interacting_Partner_3_General_References:
2719964; 2910856; 2719646; 1988031; 12761501; 10591208; 3065332; 12665801; 3611046; 2383549; 7501023; 10369126; 10764829; 11146440

# Macromolecular_Interacting_Partner_3_References:
14630391; 14769876; 16697988

# Macromolecular_Interacting_Partner_4_ID:
8343

# Macromolecular_Interacting_Partner_4_Name:
Glycodelin precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
GD; Pregnancy-associated endometrial alpha-2 globulin; PEG; PAEG; Placental protein 14; PP14; Progesterone- associated endometrial protein; Progestagen-associated endometrial protein

# Macromolecular_Interacting_Partner_4_Gene_Name:
PAEP

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Glycodelin precursor
MLCLLLTLGVALVCGVPAMDIPQTKQDLELPKLAGTWHSMAMATNNISLMATLKAPLRVH
ITSLLPTPEDNLEIVLHRWENNSCVEKKVLGEKTENPKKFKINYTVANEATLLDTDYDNF
LFLCLQDTTTPIQSMMCQYLARVLVEDDEIMQGFIRAFRPLPRHLWYLLDLKQMEEPCRF


# Macromolecular_Interacting_Partner_4_Number_of_Residues:
180

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
20625

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
5.26

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  transporter activity
Function:  binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
This protein is, quantitatively, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00061:Lipocalin

# Macromolecular_Interacting_Partner_4_Signals:
1-18

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
190215

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
PAEP_HUMAN (P09466)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
PAEP

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
PAEP

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:8573

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>489 bp
ATGGACATCCCCCAGACCAAGCAGGACCTGGAGCTCCCAAAGTTGGCAGGGACCTGGCAC
TCCATGGCCATGGCGACCAACAACATCTCCCTCATGGCGACACTGAAGGCCCCTCTGAGG
GTCCACATCACCTCACTGTTGCCCACCCCCGAGGACAACCTGGAGATCGTTCTGCACAGA
TGGGAGAACAACAGCTGTGTTGAGAAGAAGGTCCTTGGAGAGAAGACTGGGAATCCAAAG
AAGTTCAAGATCAACTATACGGTGGCGAACGAGGCCACGCTGCTCGATACTGACTACGAC
AATTTCCTGTTTCTCTGCCTACAGGACACCACCACCCCCATCCAGAGCATGATGTGCCAG
TACCTGGCCAGAGTCCTGGTGGAGGACGATGAGATCATGCAGGGATTCATCAGGGCTTTC
AGGCCCCTGCCCAGGCACCTATGGTACTTGCTGGACTTGAAACAGATGGAAGAGCCGTGC
CGTTTCTAG

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
J04129

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_4_Locus:
9q34

# Macromolecular_Interacting_Partner_4_SNPs:
rs3748210; rs783488; rs3748212; rs3748211; rs2780283; rs3827842; rs3748208; rs6537901; rs783776; rs3748207; rs3748206; rs7848434; rs3748209; rs11103063; rs2070909; rs783773; rs783772; rs12342003; rs783774; rs35415574; rs34192855; rs34495808; rs36167822; rs11267931; rs7036154; rs35630150; rs3831489; rs34058679; rs3119934; rs35993379; rs34870904; rs35171754; rs783487; rs35079156; rs34845402; rs10683006; rs10745364; rs10776821; rs10858121; rs10858123; rs10858124; rs11103066; rs12006099; rs12237669; rs12238659; rs12344201; rs13285268; rs17038696; rs17038699; rs1889136; rs2100012; rs2166239; rs34284195; rs3748204; rs3748205; rs4841882; rs697448; rs697449; rs7023309; rs705661; rs705663; rs705664; rs705666; rs705667; rs705668; rs705669; rs705670; rs783768; rs783770; rs783771; rs7857506; rs7864897; rs895189; rs895190

# Macromolecular_Interacting_Partner_4_General_References:
3194393; 2206398; 2006183; 3667877; 3569148; 11278680; 7592613; 8943270; 9239694

# Macromolecular_Interacting_Partner_4_References:
14760609; 15023474; 15200007; 15290962

# Macromolecular_Interacting_Partner_5_ID:
7923

# Macromolecular_Interacting_Partner_5_Name:
Galectin-3

# Macromolecular_Interacting_Partner_5_Synonyms:
Galactose-specific lectin 3; Mac-2 antigen; IgE-binding protein; 35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Laminin-binding protein; Lectin L-29; L-31; Galactoside-binding protein; GALBP

# Macromolecular_Interacting_Partner_5_Gene_Name:
LGALS3

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Galectin3
MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPP
GAYHGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSAPGAYPATGPYGAPAGPLIVPYNL
PLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNN
WGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDI
DLTSASYTMI

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
250

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
26189

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
8.82

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_5_Specific_Function:
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00337:Gal-bind_lectin

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
179531

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
LEG3_HUMAN (P17931)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
LGALS3

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
LGALS3

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:6563

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Nucleus. Note=Cytoplasmic in adenomas and carcinomas. May be secreted by a non-classical secretory pathway and associate with the cell surface

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>753 bp
ATGGCAGACAATTTTTCGCTCCATGATGCGTTATCTGGGTCTGGAAACCCAAACCCTCAA
GGATGGCCTGGCGCATGGGGGAACCAGCCTGCTGGGGCAGGGGGCTACCCAGGGGCTTCC
TATCCTGGGGCCTACCCCGGGCAGGCACCCCCAGGGGCTTATCCTGGACAGGCACCTCCA
GGCGCCTACCATGGAGCACCTGGAGCTTATCCCGGAGCACCTGCACCTGGAGTCTACCCA
GGGCCACCCAGCGGCCCTGGGGCCTACCCATCTTCTGGACAGCCAAGTGCCCCCGGAGCC
TACCCTGCCACTGGCCCCTATGGCGCCCCTGCTGGGCCACTGATTGTGCCTTATAACCTG
CCTTTGCCTGGGGGAGTGGTGCCTCGCATGCTGATAACAATTCTGGGCACGGTGAAGCCC
AATGCAAACAGAATTGCTTTAGATTTCCAAAGAGGGAATGATGTTGCCTTCCACTTTAAC
CCACGCTTCAATGAGAACAACAGGAGAGTCATTGTTTGCAATACAAAGCTGGATAATAAC
TGGGGAAGGGAAGAAAGACAGTCGGTTTTCCCATTTGAAAGTGGGAAACCATTCAAAATA
CAAGTACTGGTTGAACCTGACCACTTCAAGGTTGCAGTGAATGATGCTCACTTGTTGCAG
TACAATCATCGGGTTAAAAAACTCAATGAAATCAGCAAACTGGGAATTTCTGGTGACATA
GACCTCACCAGTGCTTCATATACCATGATATAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
M57710

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_5_Locus:
14q21-q22

# Macromolecular_Interacting_Partner_5_SNPs:
rs7157768; rs1047556; rs8012397; rs10149038; rs3188651; rs7160110; rs7160523; rs2147972; rs35624648; rs35652569; rs3188650; rs12161901; rs1130118; rs10629608; rs10629194; rs17095981; rs7159530; rs34212935; rs3742566; rs1009977; rs1009978; rs10140857; rs10146432; rs10148371; rs1042869; rs1042896; rs1042906; rs1042918; rs10498475; rs11001; rs11622740; rs13379284; rs15870; rs17128204; rs17128230; rs17128262; rs2075598; rs2075601; rs2075602; rs2075603; rs2182207; rs2274272; rs2274273; rs2296490; rs2340931; rs2340932; rs28405981; rs28415601; rs35954941; rs3818451; rs3825613; rs4644; rs7493394; rs8007614; rs8007620; rs8013027

# Macromolecular_Interacting_Partner_5_General_References:
2261464; 2402511; 2022338; 2009535; 7682704; 8253806; 9501082; 9582341

# Macromolecular_Interacting_Partner_5_References:
16518858; 16751604; 16818789

End of HMDB00186

Beginning of HMDB00187
# Accession_No:
HMDB00187

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-19 12:34:01

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
L-Serine

# Description:
Serine is a nonessential amino acid derived from glycine. Like all the amino acid building blocks of protein and peptides, serine can become essential under certain conditions, and is thus important in maintaining health and preventing disease. Low-average concentration of serine compared to other amino acids is found in muscle. Serine is highly concentrated in all cell membranes. (http://www.dcnutrition.com/AminoAcids/) L-Serine may be derived from four possible sources: dietary intake; biosynthesis from the glycolytic intermediate 3-phosphoglycerate; from glycine ; and by protein and phospholipid degradation. Little data is available on the relative contributions of each of these four sources of l-serine to serine homoeostasis. It is very likely that the predominant source of l-serine will be very different in different tissues and during different stages of human development. In the biosynthetic pathway, the glycolytic intermediate 3-phosphoglycerate is converted into phosphohydroxypyruvate, in a reaction catalyzed by 3-phosphoglycerate dehydrogenase (3- PGDH; EC 1.1.1.95). Phosphohydroxypyruvate is metabolized to phosphoserine by phosphohydroxypyruvate aminotransferase (EC 2.6.1.52) and, finally, phosphoserine is converted into l-serine by phosphoserine phosphatase (PSP; EC 3.1.3.3). In liver tissue, the serine biosynthetic pathway is regulated in response to dietary and hormonal changes. Of the three synthetic enzymes, the properties of 3-PGDH and PSP are the best documented. Hormonal factors such as glucagon and corticosteroids also influence 3-PGDH and PSP activities in interactions dependent upon the diet. L-serine plays a central role in cellular proliferation. L-Serine is the predominant source of one-carbon groups for the de novo synthesis of purine nucleotides and deoxythymidine monophosphate. It has long been recognized that, in cell cultures, L-serine is a conditional essential amino acid, because it cannot be synthesized in sufficient quantities to meet the cellular demands for its utilization. In recent years, L-serine and the products of its metabolism have been recognized not only to be essential for cell proliferation, but also to be necessary for specific functions in the central nervous system. The findings of altered levels of serine and glycine in patients with psychiatric disorders and the severe neurological abnormalities in patients with defects of L-serine synthesis underscore the importance of L-serine in brain development and function. (PMID 12534373)

# Synonyms:
(-)-Serine; (S)-2-Amino-3-hydroxypropanoate; (S)-2-Amino-3-hydroxypropanoic acid; (S)-2-amino-3-hydroxy-Propanoate; (S)-2-amino-3-hydroxy-Propanoic acid; (S)-Serine; (S)-a-Amino-b-hydroxypropionate; (S)-a-Amino-b-hydroxypropionic acid; (S)-alpha-Amino-beta-hydroxypropionate; (S)-alpha-Amino-beta-hydroxypropionic acid; (S)-b-Amino-3-hydroxypropionate; (S)-b-Amino-3-hydroxypropionic acid; 2-Amino-3-hydroxypropanoate; 2-Amino-3-hydroxypropanoic acid; 3-hydroxy-L-Alanine; L-(-)-Serine; L-3-Hydroxy-2-aminopropionate; L-3-Hydroxy-2-aminopropionic acid; L-3-Hydroxy-alanine; L-Ser; b-Hydroxy-L-alanine; beta-Hydroxy-L-alanine; beta-Hydroxyalanine; (S)-beta-Amino-3-hydroxypropionate; (S)-beta-Amino-3-hydroxypropionic acid

# Chemical_IUPAC_Name:
2-amino-3-hydroxy-propanoic acid

# Chemical_Formula:
C3H7NO3

# Chemical_Structure:
tbl_chemical:::HMDB00187_ZOOM.png:::119283240095855585

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00187_THUMB.png:::11928323993537140

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids; Nitrogenous Compounds

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary alcohol; 1,2-aminoalcohol; primary amine; primary aliphatic amine (alkylamine); carboxylic acid; alpha-aminoacid

# Taxonomy_Biofunction:
Component of Aminoacyl-tRNA biosynthesis; Component of Cyanoamino acid metabolism; Component of Cysteine metabolism; Component of Glycine, serine and threonine metabolism; Component of Glycosphingolipid metabolism; Component of Methane metabolism; Component of Methionine metabolism; Component of Selenoamino acid metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
105.04260

# Molecular_Weight_Avg:
105.09257

# Smiles_String_isomeric:
N[C@@H](CO)C(O)=O

# Smiles_String_canonical:
NC(CO)C(O)=O

# KEGG_Compound_ID:
C00065

# BioCyc_ID:
SER

# PubChem_CID:
5951

# PubChem_SID:
6435756; 833213; 585634; 10527490; 11111802; 829793; 7847084; 854389; 854392; 8153695; 3134386; 11113417; 828431; 11113418; 585846; 584032; 148777; 822741; 8143701; 841589; 854397; 11538396; 3365; 825474; 7890435; 739014; 824428; 6436500

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
33717

# Wikipedia_ID:
Not Available

# METLIN_ID:
5203

# Ref_ID:
12846552; 15911239; 2430261; 11860033; 12297216; 14992292; 15939521; 11602639; 16153458; 6809740; 2551543; 15099708; 16098201; 16098205; 16093978; 16092940; 6696735; 12834252; 6198473

# ChEBI_ID:
17115

# CAS_Registry_Number:
56-45-1

# InChI:
InChI=1/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1

# Synthesis_Reference:
Org. Synth., Coll. Vol., 3, 1955, 774

# Melting_Point:
228 oC

# Melting_Point_predicted:
31.8 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
425.0 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
480.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-3.07 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-3.41 [Predicted by ALOGPS]; -4 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::l-serine.pdf:::1132562213408142854

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::L-Serine.mol:::1132723812718554317

# SDF_File_[Text]:
tbl_chemical:::HMDB00187.sdf:::119283239639522099

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00187.pdb:::119283239797443973

# PDB_ID:
1IIT

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041013_P00_03_1DP_noesy.png:::116890067251282970281

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041023_P00_03_HW_1DP_presat.zip:::1175124423084543355

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041013_P00_03_1DP_Assigned.png:::115635921779316890

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041023_P00_03_HW_1DP_presat.png:::115092158083588990

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041023_P00_03_HW_1DP_presat_1.zip:::114719486872819195

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041023_P00_03_HW_2DHSQC_1014.png:::114807834361783480

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041023_P00_03_HW_2DHSQC_1014.zip:::114807834399079924

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041023_P00_03_HW_2DHSQC_1014_Assigned.png:::116284427159391465

# Predicted_H_NMR_Spectrum:
tbl_chemical:::L-Serine.gif:::1132732119859206040

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00187_peaks.txt:::1156309604257192111

# Predicted_C_NMR_Spectrum:
tbl_chemical:::L-Serine_C.gif:::1132737715761241979

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00187_peaks.txt:::1156310793532437875

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00187L.png:::117555263475253679; Medium Energy:tbl_ms:::HMDB00187M.png:::117555268769377077; High Energy:tbl_ms:::HMDB00187H.png:::117555271986666118

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000048.png:::1168908245015226

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000048.txt:::116890824501577878

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000048.png:::116890824459337818

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000048.txt:::116890824501573210

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria; peroxisome

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	28.5 (12.5-44.4)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Blood	114.0 (95.0-133.0)	umol/L	Adult:>18_yrs_old	Both	Normal	12297216
Blood	134.0+/- 38.0	N/A	Newborn:0-30_days_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	121.0 +/- 25.0	umol/L	Children:1-13_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	127.0 +/- 27.0	umol/L	Children:1-13_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	114.0 +/- 23.0	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	127.0 +/- 29.0	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	121.0 +/- 14.0	umol/L	Children:1-13_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 93. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	137.0 +/- 35.0	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 93. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	142.0 +/- 35.0	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 93. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	28.9 (20.7-37.0)	umol/L	Adult:>18_yrs_old	Both	Normal	12834252
Cerebrospinal_Fluid(CSF)	24.5 +/- 4.4	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	42.4 +/- 15.1	umol/L	Adult:>18_yrs_old	N/A	Normal	15911239
Cerebrospinal_Fluid(CSF)	28.1 +/- 4.7	umol/L	Adult:>18_yrs_old	N/A	Normal	6198473
Cerebrospinal_Fluid(CSF)	30.2 +/- 3.8	umol/L	Adult:>18_yrs_old	N/A	Normal	6198473
Cerebrospinal_Fluid(CSF)	171.0 +/- 34.0	uM	Adult:>18_yrs_old	Both	Normal	HMP Experimental


# Concentration_[Abnormal]:
Blood	10.0	umol/L	Adult:>18_yrs_old	Both	Diabetes	6696735
Blood	104.0 (101.0-107.0)	umol/L	Adult:>18_yrs_old	Both	Refractory localization-related epilepsy (RLE)	14992292
Blood	140.0 (131.0-148.0)	umol/L	Adult:>18_yrs_old	Both	Juvenile myoclonic epilepsy (JME)	14992292
Cerebrospinal_Fluid(CSF)	38.3 +/- 15.5	umol/L	N/A	N/A	Leukemia	15911239
Cerebrospinal_Fluid(CSF)	31.9 +/- 8.8	umol/L	N/A	N/A	leukemia with CNS disease	15911239


# Associated_Disorders:
Alzheimer's Disease; Diabetes; End-stage Renal Disease (ESRD); Juvenile Myoclonic Epilepsy (JME); Leukemia; leukemia with CNS disease; Refractory Localization-Related Epilepsy (RLE)

# Pathway_Names:
Glycosphingolipid metabolism;Lysine degradation;One carbon pool by folate;Methionine metabolism

# Pathway_Images:
;Lysine_degradation.jpg;;Methionine_Metabolism.jpg

# KEGG_Images:
map00600;map00310;map00670;map00271

# Pathway_Graphs:
;Lysine_degradation_Graph.jpg;;Methionine_Metabolism_Graph.jpg

# Pathway_SBMLs:
;Lysine_degradation.xml;;Methionine_Metabolism.xml

# Metabolic_Enzyme_1_ID:
6168

# Metabolic_Enzyme_1_Name:
Serine palmitoyltransferase 1

# Metabolic_Enzyme_1_Synonyms:
Long chain base biosynthesis protein 1; LCB 1; Serine-palmitoyl-CoA transferase 1; SPT 1; SPT1

# Metabolic_Enzyme_1_Gene_Name:
SPTLC1

# Metabolic_Enzyme_1_Protein_Sequence:
>Serine palmitoyltransferase 1
MATATEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERSDLTVKEKEEL
IEEWQPEPLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAA
ALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSK
RGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNPRKARVTRR
FIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDI
DLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENP
GIFAVLKEKCGQIHKALQGISGLKVVGESLSPAFHLQLEESTGSREQDVRLLQEIVDQCM
NRSIALTQARYLEKEEKCLPPPSIRVVVTVEQTEEELERAASTIKEVAQAVLL

# Metabolic_Enzyme_1_Number_of_Residues:
473

# Metabolic_Enzyme_1_Molecular_Weight:
52745

# Metabolic_Enzyme_1_Theoretical_pI:
5.87

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D- sphinganine + CO(2)

# Metabolic_Enzyme_1_Pathway:
map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_1_Reaction:
palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
16-36

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.3.1.50

# Metabolic_Enzyme_1_GenBank_ID_Protein:
2564247

# Metabolic_Enzyme_1_SwissProt_ID:
LCB1_HUMAN (O15269)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
SPTLC1

# Metabolic_Enzyme_1_Geneatlas_id:
SPTLC1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:11277

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein

# Metabolic_Enzyme_1_Gene_Sequence:
>1422 bp
ATGGCGACCGCCACGGAGCAGTGGGTTCTGGTGGAGATGGTACAGGCGCTTTACGAGGCT
CCTGCTTACCATCTTATTTTGGAAGGGATTCTGATCCTCTGGATAATCAGACTTCTTTTC
TCTAAGACTTACAAATTACAAGAACGATCTGATCTTACAGTCAAGGAAAAAGAAGAACTG
ATTGAAGAGTGGCAACCAGAACCTCTTGTTCCTCCTGTCCCAAAAGACCATCCTGCTCTC
AACTACAACATCGTTTCAGGCCCTCCAAGCCACAAAACTGTGGTGAATGGAAAAGAATGT
ATAAACTTCGCCTCATTTAATTTTCTTGGATTGTTGGATAACCCTAGGGTTAAGGCAGCA
GCTTTAGCATCTCTAAAGAAGTATGGCGTGGGGACTTGTGGACCCAGAGGATTTTATGGC
ACATTTGATGTTCATTTGGATTTGGAAGACCGCCTGGCAAAATTTATGAAGACAGAAGAA
GCCATTATATACTCATATGGATTTGCCACCATAGCCAGTGCTATTCCTGCTTACTCTAAA
AGAGGGGACATTGTTTTTGTAGATAGAGCTGCCTGCTTTGCTATTCAGAAAGGATTACAG
GCATCCCGTAGTGACATTAAGTTATTTAAGCATAATGACATGGCTGACCTCGAGCGACTA
CTAAAAGAACAAGAGATCGAAGATCAAAAGAATCCTCGCAAGGCTCGTGTAACTCGGCGT
TTCATTGTAGTAGAAGGATTGTATATGAATACTGGAACTATTTGTCCTCTTCCAGAATTG
GTTAAGTTAAAATACAAATACAAAGCAAGAATCTTCCTGGAGGAAAGCCTTTCATTTGGA
GTCCTAGGAGAGCATGGCCGAGGAGTCACTGAACACTATGGAATCAATATTGATGATATT
GATCTTATCAGTGCCAACATGGAGAATGCACTTGCTTCTATTGGAGGTTTCTGCTGTGGC
AGGTCTTTTGTAATTGACCATCAGCGACTTTCCGGCCAGGGATACTGCTTTTCAGCTTCG
TTACCTCCCCTGTTAGCTGCTGCAGCAATTGAGGCCCTCAACATCATGGAAGAGAATCCA
GGTATTTTTGCAGTGTTGAAGGAAAAGTGCGGACAAATTCATAAAGCTTTACAAGGCATT
TCTGGATTAAAAGTGGTGGGGGAGTCCCTTTCTCCAGCCTTTCACCTACAACTGGAAGAG
AGCACTGGGTCTCGCGAGCAAGATGTCAGACTGCTTCAGGAAATTGTAGATCAATGCATG
AACAGAAGTATTGCATTAACTCAGGCGCGCTACTTGGAGAAAGAAGAGAAGTGTCTCCCT
CCTCCCAGCATTCGGGTTGTGGTCACGGTGGAACAAACAGAGGAAGAACTGGAGAGAGCT
GCGTCCACCATCAAGGAGGTAGCCCAGGCCGTCCTGCTCTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
Y08685

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_1_Locus:
9q22.2

# Metabolic_Enzyme_1_SNPs:
rs7035964; rs7944; rs1892268; rs7029539; rs10820936; rs3858090; rs7863487; rs7857759; rs4560856; rs3858086; rs7041193; rs10992221; rs10820939; rs10512220; rs4604504; rs6479400; rs7024583; rs7860518; rs2297568; rs2895201; rs7027257; rs7856177; rs10820938; rs4498616; rs7858659; rs1970121; rs4344138; rs10118582; rs7854213; rs7871444; rs7018804; rs7852067; rs7872515; rs7851910; rs10992212; rs7046330; rs11790991; rs7859570; rs10119983; rs10119342; rs12380093; rs10117143; rs10820935; rs7022553; rs10992207; rs7046430; rs10992208; rs7853177; rs4518728; rs2297569; rs7037848; rs7020136; rs6479403; rs10739925; rs10761143; rs10118072; rs12338124; rs1182237; rs10820934; rs7021408; rs12006507; rs12001058; rs7034509; rs10820937; rs7021285; rs7046540; rs3847308; rs12336689; rs9697261; rs16908113; rs7021155; rs7021293; rs7046206; rs12236475; rs12345896; rs12235310; rs34640749; rs12341791; rs12350944; rs10115473; rs10992216; rs7024215; rs16908135; rs10820942; rs12339869; rs2001676; rs10992224; rs10116088; rs1182236; rs12554018; rs1317393; rs7876056; rs7870339; rs12353321; rs9776489; rs12349327; rs12352341; rs12237598; rs6479405; rs16908129; rs7025703; rs10739924; rs7859689; rs7035867; rs2186091; rs12156501; rs17749165; rs10992222; rs12344414; rs10820933; rs10117394; rs7859641; rs12336291; rs10992230; rs12006256; rs12343645; rs7862826; rs7848987; rs12336497; rs16908137; rs9696251; rs7847966; rs12343647; rs3750441; rs7870565; rs16908131; rs9696920; rs12337180; rs7856188; rs10992218; rs11533009; rs12235495; rs7871565; rs10992219; rs16908106; rs6479402; rs12237235; rs17419706; rs7040090; rs7848874; rs7865994; rs7018827; rs10992234; rs7872238; rs6479399; rs12002804; rs10123181; rs7869504; rs7018595; rs7849220; rs16908147; rs7872765; rs10122415; rs10124473; rs10118614; rs7019819; rs7350194; rs1135523; rs7024575; rs1131864; rs1135524; rs1135525; rs1131866; rs35247074; rs1135526; rs28505748; rs4514044; rs10992220; rs28759240; rs35884070; rs35060180; rs12683942; rs35320506; rs35331819; rs35050709; rs34697667; rs10115565; rs35853812; rs28552704; rs28414148; rs34928872; rs7039671; rs3996336; rs10992210; rs3996331; rs7868512; rs34606809; rs12335380; rs34801553; rs7866630; rs35205009; rs35388520; rs13299853; rs7469611; rs34085966; rs28429191; rs28768234; rs4514045; rs2895200; rs28819206; rs34541664; rs34644729; rs34023780; rs11377980; rs35310607; rs34855854; rs10122798; rs7019629; rs28735483; rs12236308; rs3996337; rs10992213; rs28391324; rs10650696; rs3957485; rs12341602; rs12338531; rs34070805; rs28637477; rs10121430; rs10992233; rs34332001; rs4641129; rs34090775; rs41279063; rs16936395; rs7019501; rs12377635; rs12553403; rs16908102; rs10992225; rs10992217; rs12347966; rs7026761; rs28877378; rs12343974; rs12005181; rs12348808; rs10118847; rs28804693; rs12235309; rs7019642; rs35766679; rs28744634; rs28430628; rs4307406; rs3996340; rs35131459; rs13290382; rs4390006; rs28513744; rs7021040; rs34268534; rs34915466; rs28727560; rs12005575; rs3076496; rs34840129; rs35563848; rs7028311; rs34464589; rs12684486; rs12237221; rs3996338; rs10681159; rs4524856; rs5899149; rs34393523; rs28437390; rs13299529; rs34545079; rs10992214; rs9696921; rs4744118; rs10992215; rs13302397; rs34005921; rs7467611; rs1185806; rs35601292; rs34405121; rs34684548; rs34332580; rs10992223; rs3996339; rs28504279; rs11790093; rs34079904; rs11355920; rs7868243; rs11791040; rs35830785; rs12343304; rs11521648; rs4595188; rs34706775; rs10992231; rs10992232; rs10992227; rs13290835; rs34090369; rs13283412; rs13283281; rs16908144; rs34527907; rs34062029; rs10553164; rs10121694; rs10123678; rs10992204; rs10992206; rs10992235; rs12349856; rs16908089; rs17589865; rs7023075; rs7024547; rs7033030; rs7044207; rs7047473; rs7048339; rs7858974

# Metabolic_Enzyme_1_General_References:
9363775; 11242114

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5901

# Metabolic_Enzyme_2_Name:
Seryl-tRNA synthetase, mitochondrial precursor

# Metabolic_Enzyme_2_Synonyms:
Seryl- tRNA(Ser/Secsynthetase; Serine--tRNA ligase; SerRSmt

# Metabolic_Enzyme_2_Gene_Name:
SARS2

# Metabolic_Enzyme_2_Protein_Sequence:
>SeryltRNA synthetase, mitochondrial precursor
MAASMARRLWPLLTRRGFRPRGGCISNDSPRRSFTTEKRNRNLLYEYAREGYSALPQLDI
ERFCACPEEAAHALELRKGELRSADLPAIISTWQELRQLQEQIRSLEEEKAAVTEAVRAL
LANQDSGEVQQDPKYQGLRARGREIRKELVHLYPREAQLEEQFYLQALKLPNQTHPDVPV
GDESQARVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQH
GLVNFTFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNIDPARFKDLNLAGTA
EVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNTGQEPRGLYRVHHFTKVEMFGVTGPG
LEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRFGEVT
SASNCTDFQSRRLHIMFQTEAGELQFAHTVNATACAVPRLLIALLESNQQKDGSVLVPPA
LQSYLGTDRITAPTHVPLQYIGPNQPRKPGLPGQPAVS

# Metabolic_Enzyme_2_Number_of_Residues:
518

# Metabolic_Enzyme_2_Molecular_Weight:
58283

# Metabolic_Enzyme_2_Theoretical_pI:
8.22

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  serine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  seryl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

# Metabolic_Enzyme_2_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_2_Reaction:
ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF02403:Seryl_tRNA_N;
PF00587:tRNA-synt_2b

# Metabolic_Enzyme_2_Signals:
1-24

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 6.1.1.11

# Metabolic_Enzyme_2_GenBank_ID_Protein:
9188535

# Metabolic_Enzyme_2_SwissProt_ID:
SYSM_HUMAN (Q9NP81)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
SARS2

# Metabolic_Enzyme_2_Geneatlas_id:
SARS2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:17697

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_2_Gene_Sequence:
>1557 bp
ATGGCTGCGTCCATGGCGCGGCGCTTGTGGCCTTTGCTGACTCGTCGGGGGTTCCGGCCC
CGGGGAGGCTGCATCTCCAACGATAGTCCAAGGAGAAGTTTCACTACAGAGAAACGAAAC
CGGAACCTCCTGTACGAGTATGCGCGCGAGGGCTACAGCGCACTCCCTCAGCTGGACATA
GAGCGGTTCTGCGCATGCCCAGAAGAGGCCGCACACGCCCTGGAGCTCCGCAAGGGGGAG
CTGCGCTCGGCGGACCTGCCCGCGATCATCTCGACATGGCAGGAGCTGAGGCAGCTGCAG
GAGCAGATCCGGAGCCTGGAGGAAGAGAAGGCAGCTGTGACTGAGGCAGTGCGGGCCCTG
CTGGCAAACCAGGACAGTGGTGAAGTGCAGCAGGACCCCAAGTACCAGGGTCTGCGGGCA
CGTGGCCGGGAGATCCGGAAGGAGCTTGTTCACCTGTACCCCAGGGAGGCCCAGCTTGAG
GAGCAGTTCTACCTGCAGGCGCTGAAGCTGCCCAACCAGACCCACCCAGACGTGCCCGTC
GGGGATGAGAGCCAGGCTCGAGTGCTCCACATGGTCGGAGACAAGCCAGTTTTCTCCTTC
CAACCTCGGGGCCACCTGGAAATTGGCGAGAAACTCGACATCATCCGTCAGAAGCGCCTG
TCCCACGTGTCTGGCCACCGGTCCTATTACCTGCGCGGGGCTGGAGCCCTCCTGCAGCAC
GGCCTGGTCAACTTCACATTCAACAAGCTTCTCCGCCGGGGCTTCACCCCCATGACGGTG
CCAGACCTTCTCCGCGGAGCAGTGTTTGAAGGCTGTGGGATGACACCAAATGCCAACCCA
TCCCAAATTTACAACATCGACCCTGCCCGCTTCAAAGATCTCAACCTGGCTGGAACAGCG
GAGGTGGGGCTTGCAGGCTACTTCATGGACCACACCGTGGCCTTCAGGGACCTGCCAGTC
AGGATGGTTTGCTCCAGCACCTGCTACCGGGCAGAGACAAACACGGGACAGGAACCCCGG
GGGCTGTATCGAGTACACCACTTCACCAAGGTGGAGATGTTTGGGGTGACAGGCCCTGGG
CTGGAGCAGAGCTCACAGCTGCTGGAGGAGTTCCTGTCCCTTCAGATGGAGATCTTGACA
GAGCTGGGCTTGCACTTCCGGGTCCTGGATATGCCCACCCAAGAACTGGGCCTCCCCGCC
TACCGCAAGTTTGACATTGAGGCCTGGATGCCAGGCCGAGGCCGCTTTGGAGAGGTCACC
AGTGCTTCCAACTGCACAGACTTCCAGAGCCGCCGCCTCCACATCATGTTCCAGACCGAG
GCTGGGGAGCTGCAGTTTGCCCACACGGTGAACGCCACCGCCTGTGCTGTCCCCCGCCTT
CTCATCGCGCTCCTGGAGAGTAACCAGCAGAAGGACGGCTCAGTGCTCGTGCCCCCTGCC
CTCCAGTCCTACCTCGGCACTGATCGGATCACAGCCCCTACCCACGTGCCTCTCCAGTAC
ATCGGCCCCAACCAGCCCCGGAAGCCTGGGCTGCCTGGCCAGCCTGCTGTAAGCTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AB029948

# Metabolic_Enzyme_2_Chromosome_Location:
Not Available

# Metabolic_Enzyme_2_Locus:
Not Available

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
10764807

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5918

# Metabolic_Enzyme_3_Name:
Seryl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_3_Synonyms:
Seryl-tRNA(Ser/Secsynthetase; Serine--tRNA ligase; SerRS

# Metabolic_Enzyme_3_Gene_Name:
SARS

# Metabolic_Enzyme_3_Protein_Sequence:
>SeryltRNA synthetase, cytoplasmic
MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC
SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE
RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGF
EGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQL
SQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTC
FRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYH
IVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKV
EFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEP
SKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA

# Metabolic_Enzyme_3_Number_of_Residues:
514

# Metabolic_Enzyme_3_Molecular_Weight:
58778

# Metabolic_Enzyme_3_Theoretical_pI:
6.38

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  serine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  seryl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

# Metabolic_Enzyme_3_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_3_Reaction:
ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF02403:Seryl_tRNA_N;
PF00587:tRNA-synt_2b

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 6.1.1.11

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1050527

# Metabolic_Enzyme_3_SwissProt_ID:
SYSC_HUMAN (P49591)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
SARS

# Metabolic_Enzyme_3_Geneatlas_id:
SARS

# Metabolic_Enzyme_3_hgnc_id:
HGNC:10537

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>1545 bp
ATGGTGCTGGATCTGGATTTGTTTCGGGTGGATAAAGGAGGGGACCCAGCCCTCATCCGA
GAGACGCAGGAGAAGCGCTTCAAGGACCCGGGACTAGTGGACCAGCTGGTGAAGGCAGAC
AGCGAGTGGCGACGATGTAGATTTCGGGCAGACAACTTGAGCAAGCTGAAGAACCTATGC
AGCAAGACAATCGGAGAGAAAATGAAGAAAAAAGAGCCAGTGGGAGATGATGAGTCTGTC
CCAGAGAATGTGCTGAGTTTCGATGACCTTACTGCAGACGCTTTAGCTAACCTGAAAGTC
TCACAAATCAAAAAAGTCCGACTCCTCATTGATGAAGCCATCCTGAAGTGTGACGCGGAG
CGGATAAAGTTGGAAGCAGAGCGGTTTGAGAACCTCCGAGAGATTGGGAACCTTCTGCAC
CCTTCTGTACCCATCAGTAACGATGAGGATGTGGACAACAAAGTAGAGAGGATTTGGGGC
GATTGTACAGTCAGGAAGAAGTACTCTCATGTGGACCTGGTGGTGATGGTAGATGGCTTT
GAAGGCGAAAAGGGGGCCGTGGTGGCTGGGAGTCGAGGGTACTTCTTGAAGGGGGTCCTG
GTGTTCCTGGAACAGGCTCTCATCCAGTATGCCCTTCGCACCTTGGGAAGTCGGGGCTAC
ATTCCCATTTATACCCCCTTTTTCATGAGGAAGGAGGTCATGCAGGAGGTGGCACAGCTC
AGCCAGTTTGATGAAGAACTTTATAAGGTGATTGGCAAAGGCAGTGAAAAGTCTGATGAC
AACTCCTATGATGAGAAGTACCTGATTGCCACCTCAGAGCAGCCCATTGCTGCCCTGCAC
CGGGATGAGTGGCTCCGGCCGGAGGACCTGCCCATCAAGTATGCTGGCCTGTCTACCTGC
TTCCGTCAGGAGGTGGGCTCCCATGGCCGTGACACCCGTGGCATCTTCCGAGTCCATCAG
TTTGAGAAGATTGAACAGTTTGTGTACTCATCACCCCATGACAACAAGTCATGGGAGATG
TTTGAAGAGATGATTACCACCGCAGAGGAGTTCTACCAGTCCCTGGGGATTCCTTACCAC
ATTGTGAATATTGTCTCAGGTTCTTTGAATCATGCTGCCAGTAAGAAGCTTGACCTGGAG
GCCTGGTTTCCGGGCTCAGGAGCCTTCCGTGAGTTGGTCTCCTGTTCTAATTGCACGGAT
TACCAGGCTCGCCGGCTTCGAATCCGATATGGGCAAACCAAGAAGATGATGGACAAGGTG
GAGTTTGTCCATATGCTCAATGCTACCATGTGCGCCACTACCCGTACCATCTGCGCCATC
CTGGAGAACTACCAGACAGAGAAGGGCATCACTGTGCCTGAGAAATTGAAGGAGTTCATG
CCGCCAGGACTGCAAGAACTGATCCCCTTTGTGAAGCCTGCGCCCATTGAGCAGGAGCCA
TCAAAGAAGCAGAAGAAGCAACATGAGGGCAGCAAAAAGAAAGCAGCAGCAAGAGACGTC
ACCCTAGAAAACAGGCTGCAGAACATGGAGGTCACCGATGCTTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X91257

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_3_Locus:
1p13.3-p13.1

# Metabolic_Enzyme_3_SNPs:
rs608511; rs683182; rs3120625; rs669697; rs600711; rs658092; rs685653; rs7539716; rs4970832; rs2924; rs687074; rs584116; rs12028612; rs2182598; rs682612; rs642581; rs626704; rs11102960; rs4970831; rs4268379; rs626784; rs1277927; rs7552768; rs11102962; rs4970830; rs3118502; rs7537308; rs7547246; rs654040; rs9661235; rs12127592; rs3118501; rs17643426; rs17856306; rs11547491; rs11547492; rs1277925; rs2358959; rs12067741; rs11380452; rs41279696; rs12403825; rs35069915; rs34158040; rs12354027; rs34115802; rs657511; rs7539230; rs35425522; rs11339198; rs12749308; rs1556768; rs1277928; rs12075220; rs35018700; rs11311821; rs34647086; rs639608; rs2281895; rs12125002; rs5776968; rs639246; rs2485323; rs7544116; rs1556769; rs631927; rs34756917; rs12129083; rs4970829; rs11102959; rs34528252; rs11439617; rs607087; rs35694777; rs2358960; rs34812410; rs12128523; rs34133284; rs12130045; rs3120626; rs3834101; rs34159080; rs11375361; rs12754293; rs35376223; rs11436487; rs3203683; rs41279698; rs11306493; rs10624420; rs654469; rs35271870; rs11804423; rs12081406; rs35625457; rs7552765; rs1277926; rs34764041; rs6703402; rs11102955; rs11102957; rs11102964; rs11102965; rs12067069; rs1277921; rs17034539; rs17034541; rs17034619; rs17035415; rs17035443; rs3088350; rs3197233; rs4246519; rs4246520; rs4623734; rs4970827; rs585362; rs586254; rs587805; rs602265; rs603643; rs604500; rs607067; rs611060; rs611905; rs611945; rs663741; rs6656935; rs688386

# Metabolic_Enzyme_3_General_References:
9431993

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
6074

# Metabolic_Enzyme_4_Name:
Serine hydroxymethyltransferase, cytosolic

# Metabolic_Enzyme_4_Synonyms:
Serine methylase; Glycine hydroxymethyltransferase; SHMT

# Metabolic_Enzyme_4_Gene_Name:
SHMT1

# Metabolic_Enzyme_4_Protein_Sequence:
>Serine hydroxymethyltransferase, cytosolic
MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA
VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG
SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV
VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL
QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL
VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK
VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL
PDF

# Metabolic_Enzyme_4_Number_of_Residues:
483

# Metabolic_Enzyme_4_Molecular_Weight:
53083

# Metabolic_Enzyme_4_Theoretical_pI:
7.77

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  glycine hydroxymethyltransferase activity
 ||
>>>
Process:  L-serine metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Interconversion of serine and glycine

# Metabolic_Enzyme_4_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00310  Lysine degradation;
 map00460  Cyanoamino acid metabolism;
 map00670  One carbon pool by folate;
 map00680  Methane metabolism

# Metabolic_Enzyme_4_Reaction:
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00464:SHMT

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.1.2.1

# Metabolic_Enzyme_4_GenBank_ID_Protein:
307422

# Metabolic_Enzyme_4_SwissProt_ID:
GLYC_HUMAN (P34896)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
SHMT1

# Metabolic_Enzyme_4_Geneatlas_id:
SHMT1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:10850

# Metabolic_Enzyme_4_PDB_ID:
1BJ4

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_4_Gene_Sequence:
>1452 bp
ATGACGATGCCAGTCAACGGGGCCCACAAGGATGCTGACCTGTGGTCCTCACATGACAAG
ATGCTGGCACAACCCCTCAAAGACAGTGATGTTGAGGTTTACAACATCATTAAGAAGGAG
AGTAACCGGCAGAGGGTTGGATTGGAGCTGATTGCCTCGGAGAATTTCGCCAGCCGAGCA
GTTTTGGAGGCCCTAGGCTCTTGCTTAAATAACAAATACTCTGAGGGGTACCCGGGCCAG
AGATACTATGGCGGGACTGAGTTTATTGATGAACTGGAGACCCTCTGTCAGAAGCGAGCC
CTGCAGGCCTATAAGCTGGACCCACAGTGCTGGGGGGTCAACGTCCAGCCCTACTCAGGC
TCCCCTGCAAACTTTGCTGTGTACACTGCCCTGGTGGAACCCCATGGGCGCATCATGGGC
CTGGACCTTCCGGATGGGGGCCACCTGACCCATGGGTTCATGACAGACAAGAAGAAAATC
TCTGCCACGTCCATCTTCTTTGAATCTATGCCCTACAAGGTGAACCCAGATACTGGCTAC
ATCAACTATGACCAGCTGGAGGAGAACGCACGCCTCTTCCACCCGAAGCTGATCATCGCA
GGAACCAGCTGCTACTCCCGAAACCTGGAATATGCCCGGCTACGGAAGATTGCAGATGAG
AACGGGGCGTATCTCATGGCGGACATGGCTCACATCAGCGGGCTGGTGGCGGCTGGCGTG
GTGCCCTCCCCATTTGAACACTGCCATGTGGTGACCACCACCACTCACAAGACCCTGCGA
GGCTGCCGAGCTGGCATGATCTTCTACAGGAAAGGAGTGAAAAGTGTGGATCCCAAGACT
GGCAAAGAGATTCTGTACAACCTGGAGTCTCTTATCAATTCTGCTGTGTTCCCTGGCCTG
CAGGGAGGTCCCCACAACCACGCCATTGCTGGGGTTGCTGTGGCACTGAAGCAAGCTATG
ACTCTGGAATTTAAAGTTTATCAACACCAGGTGGTGGCCAACTGCAGGGCTCTGTCTGAG
GCCCTGACGGAGCTGGGCTACAAAATAGTCACAGGTGGTTCTGACAACCATTTGATCCTT
GTGGATCTCCGTTCCAAAGGCACAGATGGTGGAAGGGCTGAGAAGGTGCTAGAAGCCTGT
TCTATTGCCTGCAACAAGAACACCTGTCCAGGTGACAGAAGCGCTCTGCGGCCCAGTGGA
CTGCGGCTGGGGACCCCAGCACTGACGTCCCGTGGACTTTTGGAAAAAGACTTCCAAAAA
GTAGCCCACTTTATTCACAGAGGGATAGAGCTGACCCTGCAGATCCAGAGCGACACTGGT
GTCAGAGCCACCCTGAAAGAGTTCAAGGAGAGACTGGCAGGGGATAAGTACCAGGCGGCC
GTGCAGGCTCTCCGGGAGGAGGTTGAGAGCTTCGCCTCTCTCTTCCCTCTGCCTGGCCTG
CCTGACTTCTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
L11931

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_4_Locus:
17p11.2

# Metabolic_Enzyme_4_SNPs:
rs1979277; rs7215148; rs3783; rs1979276; rs4924750; rs12952556; rs2688030; rs7211382; rs2688036; rs9902011; rs9901707; rs11867855; rs12602780; rs2273027; rs6502648; rs2125154; rs2168781; rs4925177; rs2273029; rs4925178; rs9909104; rs4924848; rs2273028; rs4500798; rs4924849; rs9904323; rs9902498; rs9910090; rs11868708; rs2273026; rs4925176; rs7215241; rs4925174; rs17806489; rs8080285; rs12937300; rs4925175; rs7215491; rs9897954; rs6502649; rs7207306; rs11078415; rs11869515; rs3794772; rs12603682; rs1975822; rs9899244; rs12451555; rs12601687; rs8070633; rs8070162; rs7217566; rs6502650; rs12939092; rs8073464; rs7216214; rs4925180; rs638318; rs9748196; rs1975821; rs4925179; rs12451698; rs6502652; rs12949119; rs12939757; rs593297; rs10560621; rs12950117; rs12603525; rs10605292; rs2045463; rs10560620; rs1801438; rs9907815; rs34046905; rs6502651; rs28842509; rs35758894; rs35958900; rs599147; rs12603622; rs3866955; rs35176939; rs34396945; rs35675509; rs36074773; rs4924850; rs9893653; rs9891958; rs11652808; rs640629; rs28479066; rs8076444; rs35371970; rs35017109; rs9890189; rs9890744; rs12451807; rs7222930; rs9915858; rs34314562; rs3039790; rs10163522; rs8074044; rs641028; rs12952667; rs35782384; rs8074369; rs3794773; rs35005892; rs41313224; rs35818260; rs11415006; rs33997817; rs8080168; rs34157006; rs36102200; rs10655994; rs11649868; rs28823869; rs35253049; rs12450760; rs9901339; rs9905667; rs28895954; rs7219549; rs35552686; rs11649727; rs28893340; rs28630807; rs34568590; rs34135775; rs17806333; rs10669899; rs35431354; rs11659056; rs11658098; rs11649725; rs35628660; rs9891024; rs7217603; rs941454; rs2461837; rs2461838; rs4924845; rs4924846; rs4924847; rs4925169; rs4925170; rs4925171; rs4925172; rs4925173; rs638416; rs643333; rs6502646; rs669340; rs672356; rs7213472; rs8065874; rs921865; rs921866; rs921985; rs921986; rs9894406; rs9898323; rs9900382; rs9901160; rs9906010; rs9907337; rs9909530; rs9913022

# Metabolic_Enzyme_4_General_References:
8505317; 9056951; 9753690

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
6169

# Metabolic_Enzyme_5_Name:
Phosphoserine phosphatase

# Metabolic_Enzyme_5_Synonyms:
PSP; O-phosphoserine phosphohydrolase; PSPase; L-3-phosphoserine phosphatase

# Metabolic_Enzyme_5_Gene_Name:
PSPH

# Metabolic_Enzyme_5_Protein_Sequence:
>Phosphoserine phosphatase
MVSHSELRKLFYSADAVCFDVDSTVIREEGIDELAKICGVEDAVSEMTRRAMGGAVPFKA
ALTERLALIQPSREQVQRLIAEQPPHLTPGIRELVSRLQERNVQVFLISGGFRSIVEHVA
SKLNIPATNVFANRLKFYFNGEYAGFDETQPTAESGGKGKVIKLLKEKFHFKKIIMIGDG
ATDMEACPPADAFIGFGGNVIRQQVKDNAKWYITDFVELLGELEE

# Metabolic_Enzyme_5_Number_of_Residues:
225

# Metabolic_Enzyme_5_Molecular_Weight:
25008

# Metabolic_Enzyme_5_Theoretical_pI:
5.42

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  phosphoserine phosphatase activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  L-serine metabolism
Process:  L-serine biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates

# Metabolic_Enzyme_5_Pathway:
map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_5_Reaction:
L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00702:Hydrolase

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.1.3.3

# Metabolic_Enzyme_5_GenBank_ID_Protein:
1890331

# Metabolic_Enzyme_5_SwissProt_ID:
SERB_HUMAN (P78330)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
PSPH

# Metabolic_Enzyme_5_Geneatlas_id:
PSPH

# Metabolic_Enzyme_5_hgnc_id:
HGNC:9577

# Metabolic_Enzyme_5_PDB_ID:
1NNL

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_5_Gene_Sequence:
>678 bp
ATGGTCTCCCACTCAGAGCTGAGGAAGCTTTTCTACTCAGCAGATGCTGTGTGTTTTGAT
GTTGACAGCACGGTCATCAGAGAAGAAGGAATCGATGAGCTAGCCAAAATCTGTGGCGTT
GAGGACGCGGTGTCAGAAATGACACGGCGAGCCATGGGCGGGGCAGTGCCTTTCAAAGCT
GCTCTCACAGAGCGCTTAGCCCTCATCCAGCCCTCCAGGGAGCAGGTGCAGAGACTCATA
GCAGAGCAACCCCCACACCTGACCCCCGGCATAAGGGAGCTGGTAAGTCGCCTACAGGAG
CGAAATGTTCAGGTTTTCCTAATATCTGGTGGCTTTAGGAGTATTGTAGAGCATGTTGCT
TCAAAGCTCAATATCCCAGCAACCAATGTATTTGCCAATAGGCTGAAATTCTACTTTAAC
GGTGAATATGCAGGTTTTGATGAGACGCAGCCAACAGCTGAATCTGGTGGAAAAGGAAAA
GTGATTAAACTTTTAAAGGAAAAATTTCATTTTAAGAAAATAATCATGATTGGAGATGGT
GCCACAGATATGGAAGCCTGTCCTCCTGCTGATGCTTTCATTGGATTTGGAGGAAATGTG
ATCAGGCAACAAGTCAAGGATAACGCCAAATGGTATATCACTGATTTTGTAGAGCTGCTG
GGAGAACTGGAAGAATAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
Y10275

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_5_Locus:
7p15.2-p15.1

# Metabolic_Enzyme_5_SNPs:
rs7793536; rs4275190; rs4947534; rs10259981; rs7801940; rs4948102; rs7784104; rs2016724; rs1064337; rs10265826; rs13240915; rs34530076; rs13241866; rs6962857; rs6979190; rs6965614; rs13241531; rs10279542; rs7791221; rs1057603; rs6955423; rs13244123; rs4255091; rs7791829; rs4496923; rs11238389; rs10251184; rs11982472; rs11984080; rs7784761; rs36049923; rs13230954; rs12113229; rs34378629; rs35283892; rs35662903; rs34319969; rs35544148; rs28378935; rs35881493; rs36059374; rs11975582; rs35102510; rs13244131; rs7776550; rs34876866; rs9649860; rs13232781; rs28478753; rs34620559; rs34887035; rs36044787; rs35136814; rs35551160; rs7811755; rs13222267; rs34994328; rs34885337; rs10234801; rs13227670; rs13222532; rs35759842; rs2002693; rs34727399; rs28377191; rs35931085; rs36090435; rs13231103; rs28551644; rs10680450; rs11322718; rs11396939; rs13222536; rs35347055; rs35523043; rs13244125; rs10241568; rs10243007; rs10234256; rs13237941; rs34477367; rs35552809; rs34707207; rs6964658; rs35401342; rs34436132; rs10274148; rs34486411; rs6973917; rs34664922; rs35940549; rs35069257; rs35210477; rs11549718; rs6975311; rs6974880; rs34528611; rs34667212; rs2002651; rs11314097; rs11394881; rs4948103; rs13228848; rs28670952; rs34102509; rs34124342; rs35041374; rs35888472; rs10274231; rs35744032; rs6954669; rs28594969; rs6955615; rs35058595; rs11412043; rs13232523; rs35972367; rs34367217; rs34306132; rs35989028; rs35860273; rs6948553; rs7801405; rs35668227; rs34353407; rs11431840; rs34329610; rs34287940; rs36126335; rs6970842; rs13228321; rs28594885; rs6970276; rs13228900; rs4948101; rs34766579; rs33922584; rs34822782; rs3757852; rs6593296; rs7779821; rs7781165; rs7800001

# Metabolic_Enzyme_5_General_References:
9188776

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
6069

# Metabolic_Enzyme_6_Name:
Serine--pyruvate aminotransferase

# Metabolic_Enzyme_6_Synonyms:
SPT; Alanine-- glyoxylate aminotransferase; AGT

# Metabolic_Enzyme_6_Gene_Name:
AGXT

# Metabolic_Enzyme_6_Protein_Sequence:
>Serinepyruvate aminotransferase
MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEI
KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG
ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLL
LVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF
YLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHG
RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLR
IGLLGCNATRENVDRVTEALRAALQHCPKKKL

# Metabolic_Enzyme_6_Number_of_Residues:
392

# Metabolic_Enzyme_6_Molecular_Weight:
43011

# Metabolic_Enzyme_6_Theoretical_pI:
8.55

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
L-serine + pyruvate = 3-hydroxypyruvate + L- alanine

# Metabolic_Enzyme_6_Pathway:
map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_6_Reaction:
L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00266:Aminotran_5

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.6.1.51;EC 2.6.1.44

# Metabolic_Enzyme_6_GenBank_ID_Protein:
36582

# Metabolic_Enzyme_6_SwissProt_ID:
SPYA_HUMAN (P21549)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
AGXT

# Metabolic_Enzyme_6_Geneatlas_id:
AGXT

# Metabolic_Enzyme_6_hgnc_id:
HGNC:341

# Metabolic_Enzyme_6_PDB_ID:
1H0C

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Peroxisome. Note=Except in some PH1 patients where AGT is found in the mitochondrial matrix

# Metabolic_Enzyme_6_Gene_Sequence:
>1179 bp
ATGGCCTCTCACAAGCTGCTGGTGACCCCCCCCAAGGCCCTGCTCAAGCCCCTCTCCATC
CCCAACCAGCTCCTGCTGGGGCCTGGTCCTTCCAACCTGCCTCCTCGCATCATGGCAGCC
GGGGGGCTGCAGATGATCGGGTCCATGAGCAAGGATATGTACCAGATCATGGACGAGATC
AAGGAAGGCATCCAGTACGTGTTCCAGACCAGGAACCCACTCACACTGGTCATCTCTGGC
TCGGGACACTGTGCCCTGGAGGCCGCCCTGGTCAATGTGCTGGAGCCTGGGGACTCCTTC
CTGGTTGGGGCCAATGGCATTTGGGGGCAGCGAGCCGTGGACATCGGGGAGCGCATAGGA
GCCCGAGTGCACCCGATGACCAAGGACCCTGGAGGCCACTACACACTGCAGGAGGTGGAG
GAGGGCCTGGCCCAGCACAAGCCAGTGCTGCTGTTCTTAACCCACGGGGAGTCGTCCACC
GGCGTGCTGCAGCCCCTTGATGGCTTCGGGGAACTCTGCCACAGGTACAAGTGCCTGCTC
CTGGTGGATTCGGTGGCATCCCTGGGCGGGACCCCCCTTTACATGGACCGGCAAGGCATC
GACATCCTGTACTCGGGCTCCCAGAAGGCCCTGAACGCCCCTCCAGGGACCTCGCTCATC
TCCTTCAGTGACAAGGCCAAAAAGAAGATGTACTCCCGCAAGACGAAGCCCTTCTCCTTC
TACCTGGACATCAAGTGGCTGGCCAACTTCTGGGGCTGTGACGACCAGCCCAGGATGTAC
CATCACACAATCCCCGTCATCAGCCTGTACAGCCTGAGAGAGAGCCTGGCCCTCATTGCG
GAACAGGGCCTGGAGAACAGCTGGCGCCAGCACCGCGAGGCCGCGGCGTATCTGCATGGG
CGCCTGCAGGCACTGGGGCTGCAGCTCTTCGTGAAGGACCCGGCGCTCCGGCTTCCCACA
GTCACCACTGTGGCTGTACCCGCTGGCTATGACTGGAGAGACATCGTCAGCTACGTCATA
GACCACTTCGACATTGAGATCATGGGTGGCCTTGGGCCCTCCACGGGGAAGGTGCTGCGG
ATCGGCCTGCTGGGCTGCAATGCCACCCGCGAGAATGTGGACCGCGTGACGGAGGCCCTG
AGGGCGGCCCTGCAGCACTGCCCCAAGAAGAAGCTGTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
X56092

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_6_Locus:
2q36-q37

# Metabolic_Enzyme_6_SNPs:
rs4426527; rs13408961; rs34885252; rs34116584; rs33958047; rs4273214; rs4344931; rs4073369; rs4073370; rs12695032; rs6732985; rs4073597; rs10199038; rs11681134; rs11894759; rs12478859; rs10933640; rs4355101; rs13430507; rs13423821; rs5021686; rs5013752; rs11901056; rs11687303; rs10933641; rs13030904; rs11693280; rs11685698; rs11886288; rs4675876; rs4675875; rs4234095; rs10182575; rs34664134; rs35977912; rs35698882; rs3196760; rs4991357; rs11682457; rs11688815; rs11691745; rs35882315; rs12997245; rs4991356; rs33996129; rs6722479; rs4991354; rs4414673; rs5839789; rs35937797; rs12464426; rs4991360; rs34134404; rs35561942; rs4991355; rs5839787; rs34995778; rs34572785; rs10196315; rs13020254; rs11691886; rs35566646; rs5839788; rs4257395; rs4991359; rs5013751; rs4328626; rs4991361; rs35172778; rs5839786; rs4991358; rs5021687; rs4675793; rs12622523; rs34927888; rs12998301; rs11897804; rs7568864; rs4675877; rs6718131; rs35931917; rs35082207; rs12619921; rs6717643; rs10177846; rs10178744; rs10185214; rs10933510; rs1138103; rs11680732; rs11681382; rs11686679; rs11689640; rs11886874; rs11899555; rs12616061; rs12991730; rs12994627; rs13000529; rs13001584; rs13007644; rs13025495; rs13030611; rs13385816; rs13387029; rs13397515; rs13410652; rs33998315; rs34927891; rs36014033; rs4129624; rs4295000; rs4311055; rs4312490; rs4465762; rs4538195; rs4675792; rs4675869; rs4675871; rs4675872; rs4675874; rs6437372; rs6707763; rs6708304; rs6741220; rs6744422; rs7340215; rs7340501; rs7355583; rs7557279; rs7590032; rs7598309; rs7600847; rs7601670; rs7604393; rs7606856; rs9288742

# Metabolic_Enzyme_6_General_References:
2253628; 1703535; 2363689; 2045108; 2039493; 1349575; 1301173; 8101040; 8507692; 9192270; 10394939; 10862087

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
6072

# Metabolic_Enzyme_7_Name:
Serine hydroxymethyltransferase, mitochondrial precursor

# Metabolic_Enzyme_7_Synonyms:
Serine methylase; Glycine hydroxymethyltransferase; SHMT

# Metabolic_Enzyme_7_Gene_Name:
SHMT2

# Metabolic_Enzyme_7_Protein_Sequence:
>Serine hydroxymethyltransferase, mitochondrial precursor
MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELL
QREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQ
RRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV
KRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREV
CDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVD
PKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARA
MADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAIT
PGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQ
RLANLRQRVEQFARAFPMPGFDEH

# Metabolic_Enzyme_7_Number_of_Residues:
504

# Metabolic_Enzyme_7_Molecular_Weight:
55994

# Metabolic_Enzyme_7_Theoretical_pI:
8.67

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  glycine hydroxymethyltransferase activity
 ||
>>>
Process:  L-serine metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Interconversion of serine and glycine

# Metabolic_Enzyme_7_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00310  Lysine degradation;
 map00460  Cyanoamino acid metabolism;
 map00670  One carbon pool by folate;
 map00680  Methane metabolism

# Metabolic_Enzyme_7_Reaction:
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00464:SHMT

# Metabolic_Enzyme_7_Signals:
1-18

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.1.2.1

# Metabolic_Enzyme_7_GenBank_ID_Protein:
746436

# Metabolic_Enzyme_7_SwissProt_ID:
GLYM_HUMAN (P34897)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
SHMT2

# Metabolic_Enzyme_7_Geneatlas_id:
SHMT2

# Metabolic_Enzyme_7_hgnc_id:
HGNC:10852

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_7_Gene_Sequence:
>1452 bp
ATGGCCATTCGGGCTCAGCACAGCAACGCAGCCCAGACTCAGACTGGGGAAGCAAACAGG
GGCTGGACAGGCCAGGAGAGCCTGTCGGACAGTGATCCTGAGATGTGGGAGTTGCTGCAG
AGGGAGAAGGACAGGCAGTGTCGTGGCCTGGAGCTCATTGCCTCAGAGAACTTCTGCAGC
CGAGCTGCGCTGGAGGCCCTGGGGTCCTGTCTGAACAACAAGTACTCGGAGGGTTATCCT
GGCAAGAGATACTATGGGGGAGCAGAGGTGGTGGATGAAATTGAGCTGCTGTGCCAGCGC
CGGGCCTTGGAAGCCTTTGACCTGGATCCTGCACAGTGGGGAGTCAATGTCCAGCCCTAC
TCCGGGTCCCCAGCCAACCTGGCCGTCTACACAGCCCTTCTGCAACCTCACGACCGGATC
ATGGGGCTGGACCTGCCCGATGGGGGCCATCTCACCCACGGCTACATGTCTGACGTCAAG
CGGATATCAGCCACGTCCATCTTCTTCGAGTCTATGCCCTATAAGCTCAACCCCAAAACT
GGCCTCATTGACTACAACCAGCTGGCACTGACTGCTCGACTTTTCCGGCCACGGCTCATC
ATAGCTGGCACCAGCGCCTATGCTCGCCTCATTGACTACGCCCGCATGAGAGAGGTGTGT
GATGAAGTCAAAGCACACCTGCTGGCAGACATGGCCCACATCAGTGGCCTGGTGGCTGCC
AAGGTGATTCCCTCGCCTTTCAAGCACGCGGACATCGTCACCACCACTACTCACAAGACT
CTTCGAGGGGCCAGGTCAGGGCTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGGACCCC
AAGACTGGCCGGGAGATCCCTTACACATTTGAGGACCGAATCAACTTTGCCGTGTTCCCA
TCCCTGCAGGGGGGCCCCCACAATCATGCCATTGCTGCAGTAGCTGTGGCCCTAAAGCAG
GCCTGCACCCCCATGTTCCGGGAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGGCCATG
GCAGATGCCCTGCTAGAGCGAGGCTACTCACTGGTATCAGGTGGTACTGACAACCACCTG
GTGCTGGTGGACCTGCGGCCCAAGGGCCTGGATGGAGCTCGGGCTGAGCGGGTGCTAGAG
CTTGTATCCATCACTGCCAACAAGAACACCTGTCCTGGAGACCGAAGTGCCATCACACCG
GGCGGCCTGCGGCTTGGGGCCCCAGCCTTAACTTCTCGACAGTTCCGTGAGGATGACTTC
CGGAGAGTTGTGGACTTTATAGATGAAGGGGTCAACATTGGCTTAGAGGTGAAGAGCAAG
ACTGCCAAGCTCCAGGATTTCAAATCCTTCCTGCTTAAGGACTCAGAAACAAGTCAGCGT
CTGGCCAACCTCAGGCAACGGGTGGAGCAGTTTGCCAGGGCCTTCCCCATGCCTGGTTTT
GATGAGCATTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
U23143

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_7_Locus:
12q12-q14

# Metabolic_Enzyme_7_SNPs:
rs2229717; rs2229718; rs2229716; rs11615783; rs28365862; rs28365863; rs7301155; rs12319666; rs11557165; rs11557163; rs11557167; rs11557162; rs14201; rs2229715; rs11557166; rs10603176; rs28365864; rs34095989; rs34808817; rs35850385; rs35467141; rs12826178; rs10717122; rs35603162; rs10783815; rs11609986; rs11612037; rs11612551; rs11829843; rs3204635; rs35132254; rs6581130; rs7134826; rs7485577

# Metabolic_Enzyme_7_General_References:
8999870; 8505317; 10828359

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
6059

# Metabolic_Enzyme_8_Name:
Cystathionine beta-synthase

# Metabolic_Enzyme_8_Synonyms:
Serine sulfhydrase; Beta- thionase

# Metabolic_Enzyme_8_Gene_Name:
CBS

# Metabolic_Enzyme_8_Protein_Sequence:
>Cystathionine betasynthase
MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPSRCTWQLGRPA
SESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKD
RISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDV
LRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEI
LQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPEGSILAEPEELNQTEQTT
YEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKA
AQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLS
APLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVG
KVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLL
NFVAAQERDQK

# Metabolic_Enzyme_8_Number_of_Residues:
551

# Metabolic_Enzyme_8_Molecular_Weight:
60587

# Metabolic_Enzyme_8_Theoretical_pI:
6.63

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  lyase activity
Function:  carbon-oxygen lyase activity
Function:  hydro-lyase activity
Function:  cystathionine beta-synthase activity
Function:  catalytic activity
 ||
>>>
Process:  sulfur amino acid metabolism
Process:  sulfur amino acid biosynthesis
Process:  cysteine biosynthesis
Process:  cysteine biosynthesis via cystathione
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  L-serine metabolism
Process:  cysteine biosynthesis from serine
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_8_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
L-serine + L-homocysteine = L-cystathionine + H(2)O

# Metabolic_Enzyme_8_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00271  Methionine metabolism;
 map00450  Selenoamino acid metabolism

# Metabolic_Enzyme_8_Reaction:
L-serine + L-homocysteine = cystathionine + H2O

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00571:CBS;
PF00291:PALP

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 4.2.1.22

# Metabolic_Enzyme_8_GenBank_ID_Protein:
388716

# Metabolic_Enzyme_8_SwissProt_ID:
CBS_HUMAN (P35520)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
CBS

# Metabolic_Enzyme_8_Geneatlas_id:
CBS

# Metabolic_Enzyme_8_hgnc_id:
HGNC:1550

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasm. Nucleus

# Metabolic_Enzyme_8_Gene_Sequence:
>1656 bp
ATGCCTTCTGAGACCCCCCAGGCAGAAGTGGGGCCCACAGGCTGCCCCCACCGCTCAGGG
CCACACTCGGCGAAGGGGAGCCTGGAGAAGGGGTCCCCAGAGGATAAGGAAGCCAAGGAG
CCCCTGTGGATCCGGCCCGATGCTCCGAGCAGGTGCACCTGGCAGCTGGGCCGGCCTGCC
TCCGAGTCCCCACATCACCACACTGCCCCGGCAAAATCTCCAAAAATCTTGCCAGATATT
CTGAAGAAAATCGGGGACACCCCTATGGTCAGAATCAACAAGATTGGGAAGAAGTTCGGC
CTGAAGTGTGAGCTCTTGGCCAAGTGTGAGTTCTTCAACGCGGGCGGGAGCGTGAAGGAC
CGCATCAGCCTGCGGATGATTGAGGATGCTGAGCGCGACGGGACGCTGAAGCCCGGGGAC
ACGATTATCGAGCCGACATCCGGGAACACCGGGATCGGGCTGGCCCTGGCTGCGGCAGTG
AGGGGCTATCGCTGCATCATCGTGATGCCAGAGAAGATGAGCTCCGAGAAGGTGGACGTG
CTGCGGGCACTGGGGGCTGAGATTGTGAGGACGCCCACCAATGCCAGGTTCGACTCCCCG
GAGTCACACGTGGGGGTGGCCTGGCGGCTGAAGAACGAAATCCCCAATTCTCACATCCTA
GACCAGTACCGCAACGCCAGCAACCCCCTGGCTCACTACGACACCACCGCTGATGAGATC
CTGCAGCAGTGTGATGGGAAGCTGGACATGCTGGTGGCTTCAGTGGGCACGGGCGGCACC
ATCACGGGCATTGCCAGGAAGCTGAAGGAGAAGTGTCCTGGATGCAGGATCATTGGGGTG
GATCCCGAAGGGTCCATCCTCGCAGAGCCGGAGGAGCTGAACCAGACGGAGCAGACAACC
TACGAGGTGGAAGGGATCGGCTACGACTTCATCCCCACGGTGCTGGACAGGACGGTGGTG
GACAAGTGGTTCAAGAGCAACGATGAGGAGGCGTTCACCTTTGCCCGCATGCTGATCGCG
CAAGAGGGGCTGCTGTGCGGTGGCAGTGCTGGCAGCACGGTGGCGGTGGCCGTGAAGGCT
GCGCAGGAGCTGCAGGAGGGCCAGCGCTGCGTGGTCATTCTGCCCGACTCAGTGCGGAAC
TACATGACCAAGTTCCTGAGCGACAGGTGGATGCTGCAGAAGGGCTTTCTGAAGGAGGAG
GACCTCACGGAGAAGAAGCCCTGGTGGTGGCACCTCCGTGTTCAGGAGCTGGGCCTGTCA
GCCCCGCTGACCGTGCTCCCGACCATCACCTGTGGGCACACCATCGAGATCCTCCGGGAG
AAGGGCTTCGACCAGGCGCCCGTGGTGGATGAGGCGGGGGTAATCCTGGGAATGGTGACG
CTTGGGAACATGCTCTCGTCCCTGCTTGCCGGGAAGGTGCAGCCGTCAGACCAAGTTGGC
AAAGTCATCTACAAGCAGTTCAAACAGATCCGCCTCACGGACACGCTGGGCAGGCTCTCG
CACATCCTGGAGATGGACCACTTCGCCCTGGTGGTGCACGAGCAGATCCAGTACCACAGC
ACCGGGAAGTCCAGTCAGCGGCAGATGGTGTTCGGGGTGGTCACCGCCATTGACTTGCTG
AACTTCGTGGCCGCCCAGGAGCGGGACCAGAAGTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
L19501

# Metabolic_Enzyme_8_Chromosome_Location:
Not Available

# Metabolic_Enzyme_8_Locus:
Not Available

# Metabolic_Enzyme_8_SNPs:
rs11700812; rs34040148; rs5742905; rs1801181; rs234706; rs2298758; rs706208; rs706209; rs12613; rs1051319; rs9982921; rs855780; rs9980564; rs4987122; rs2605308; rs2124459; rs6586283; rs2014564; rs2851391; rs2124458; rs234705; rs234715; rs2124460; rs6586281; rs2849729; rs4920037; rs2124461; rs234713; rs6586282; rs8132811; rs234712; rs11203172; rs2849727; rs234711; rs234709; rs397589; rs1789953; rs234714; rs11701048; rs234708; rs3788053; rs8132812; rs234707; rs11700992; rs3788051; rs760124; rs7276016; rs234702; rs9979325; rs3788050; rs35169520; rs36055171; rs34758144; rs2849728; rs9325622; rs9974224; rs4987123; rs2298759; rs35052117; rs234710; rs234704; rs13049958; rs3788052; rs9982015; rs35307078; rs35108415; rs1005584; rs35196215; rs11910385; rs1005585; rs12329764; rs1788484; rs13046827; rs2850144; rs11700748; rs17849313; rs28934892; rs34719150; rs28934891; rs2228298; rs34512829; rs34310920; rs2849731; rs855778; rs9978104; rs2850142; rs34462715; rs9983620; rs1803363; rs2850143; rs9980464; rs855779; rs34338239; rs35748451; rs1788467; rs855781; rs12626371; rs1051316; rs35560741; rs7276378; rs2895956; rs7279359; rs2298760; rs34540454; rs1788466; rs34612112; rs34035512; rs9975882; rs35158583; rs34345711; rs13046562; rs13051707; rs13052765; rs5844150; rs34966728; rs35491360; rs35034449; rs234701; rs9978861; rs13052774; rs10633769; rs34937797; rs11396320; rs13046552; rs34296490; rs2298761; rs34058998; rs34623684; rs35254159; rs13046893; rs35338183; rs2851392; rs13052870; rs34726873; rs33943377; rs10569459; rs13050450; rs13050197; rs8131163; rs34547320; rs35093797; rs8127973; rs2851393; rs234703; rs9978863; rs34612348; rs34210699; rs13046443; rs35957156; rs5844149; rs34528892; rs11552089; rs34718891; rs1788465; rs7278195; rs35990176; rs2244171; rs7279312; rs2849730; rs10599152; rs9637292; rs2850145; rs9637291; rs28825153; rs3045427; rs2276336; rs11909493; rs11911976; rs13047437; rs1515; rs1518; rs1672116; rs1672123; rs1672124; rs1672126; rs1788464; rs1788487; rs1788490; rs1809212; rs234783; rs234784; rs234785; rs2401191; rs2401192; rs2401194; rs2401195; rs28360502; rs2839631; rs2850146; rs373105; rs392225; rs3972; rs400660; rs411441; rs416943; rs418639; rs439944; rs440099; rs442259; rs466791; rs4919959; rs719037; rs719038; rs8127036; rs8128028; rs8133239; rs88483; rs897521; rs897522; rs915853

# Metabolic_Enzyme_8_General_References:
7903580; 7598711; 8022826; 9383285; 9790750; 681363; 11483494; 12173932; 10338090; 1301198; 8353501; 7506602; 7981678; 7849717; 7967489; 7611293; 7762555; 7635485; 8528202; 7564249; 8755636; 8803779; 9156316; 9361025; 8990018; 9266356; 10408774

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5944

# Metabolic_Enzyme_9_Name:
L-serine dehydratase

# Metabolic_Enzyme_9_Synonyms:
L-serine deaminase

# Metabolic_Enzyme_9_Gene_Name:
SDS

# Metabolic_Enzyme_9_Protein_Sequence:
>Lserine dehydratase
MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAHF
VCSSAGNAGMAAAYAARQLGVPATIVVPGTTPALTIERLKNEGATCKVVGELLDEAFELA
KALAKNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEKPGAIALSVGGGGLLCGVVQGL
QECGWGDVPVIAMETFGAHSFHAATTAGKLVSLPKITSVAKALGVKTVGSQALKLFQEHP
IFSEVISDQEAVAAIEKFVDDEKILVEPAWGAALAAVYSHVIQKLQLEGNLRTPLPSLVV
IVCGGSNISLAQLRALKEQLGMTNRLPK

# Metabolic_Enzyme_9_Number_of_Residues:
328

# Metabolic_Enzyme_9_Molecular_Weight:
34703

# Metabolic_Enzyme_9_Theoretical_pI:
8.07

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
L-serine = pyruvate + NH(3)

# Metabolic_Enzyme_9_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00272  Cysteine metabolism

# Metabolic_Enzyme_9_Reaction:
L-serine = pyruvate + NH3

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00291:PALP

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 4.3.1.17

# Metabolic_Enzyme_9_GenBank_ID_Protein:
338030

# Metabolic_Enzyme_9_SwissProt_ID:
SDHL_HUMAN (P20132)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
SDS

# Metabolic_Enzyme_9_Geneatlas_id:
SDS

# Metabolic_Enzyme_9_hgnc_id:
HGNC:10691

# Metabolic_Enzyme_9_PDB_ID:
1P5J

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_9_Gene_Sequence:
>987 bp
ATGATGTCTGGAGAACCCCTGCACGTGAAGACCCCCATCCGTGACAGCATGGCCCTGTCC
AAAATGGCCGGCACCAGCGTCTACCTCAAGATGGACAGTGCCCAGCCCTCCGGCTCCTTC
AAGATCCGGGGCATTGGGCACTTCTGCAAGAGGTGGGCCAAGCAAGGCTGTGCACATTTT
GTCTGCTCCTCGGCGGGCAACGCAGGCATGGCGGCTGCATATGCGGCCAGGCAACTCGGC
GTCCCCGCCACCATCGTAGTGCCCGGCACCACACCTGCTCTCACCATTGAGCGCCTCAAG
AATGAAGGTGCCACATGCAAGGTGGTGGGTGAGTTATTGGATGAAGCCTTCGAGCTGGCC
AAGGCCCTAGCGAAGAACAACCCGGGTTGGGTCTACATTCCCCCCTTTGATGACCCCCTC
ATCTGGGAAGGCCACGCTTCCATCGTGAAAGAGCTGAAGGAGACACTGTGGGAAAAGCCG
GGGGCCATCGCGCTGTCAGTGGGCGGCGGGGGCCTGCTGTGTGGAGTGGTCCAGGGGCTG
CAGGAGTGTGGCTGGGGGGACGTGCCTGTCATCGCCATGGAGACTTTTGGTGCCCACAGC
TTCCACGCTGCCACCACCGCAGGCAAACTTGTCTCCCTGCCCAAGATCACCAGTGTTGCC
AAGGCCCTGGGCGTGAAGACTGTGGGGTCTCAGGCCCTGAAGCTGTTTCAGGAACACCCC
ATTTTCTCTGAAGTTATCTCGGACCAGGAGGCTGTGGCCGCCATTGAGAAGTTCGTGGAT
GATGAGAAGATCCTGGTGGAGCCCGCCTGGGGCGCAGCCCTGGCCGCTGTCTATAGCCAC
GTGATCCAGAAGCTCCAACTGGAGGGGAATCTCCGAACCCCGCTGCCATCCCTCGTGGTC
ATCGTCTGCGGGGGCAGCAACATCAGCCTGGCCCAGCTGCGGGCGCTCAAGGAACAGCTG
GGCATGACAAATAGGTTGCCCAAGTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
J05037

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_9_Locus:
12q24.13

# Metabolic_Enzyme_9_SNPs:
rs3812826; rs7960943; rs7980117; rs16942781; rs11609455; rs2069251; rs12820484; rs12832115; rs11829715; rs12833309; rs7135421; rs1050062; rs35465493; rs34607566; rs35638951; rs12306986; rs34954765; rs35429206; rs5800985; rs12824553; rs10624677; rs35911976; rs36075425; rs2303622; rs34218141; rs12824546; rs35764330; rs35270874; rs34219581; rs35190353; rs3794315; rs34550115; rs34835808; rs12766; rs7135290; rs13603; rs34921153; rs34099285; rs7135256; rs7135675; rs12304687; rs34839349; rs35942568; rs11420; rs34969035; rs34862362; rs34014624; rs11066549; rs11066552; rs11066553; rs11831414; rs11832103; rs12425042; rs12812648; rs12815112; rs12818674; rs34803330; rs35106464

# Metabolic_Enzyme_9_General_References:
2674117

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
6170

# Metabolic_Enzyme_10_Name:
Serine palmitoyltransferase 2

# Metabolic_Enzyme_10_Synonyms:
Long chain base biosynthesis protein 2; LCB 2; Serine-palmitoyl-CoA transferase 2; SPT 2

# Metabolic_Enzyme_10_Gene_Name:
SPTLC2

# Metabolic_Enzyme_10_Protein_Sequence:
>Serine palmitoyltransferase 2
MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFN
EAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFEN
FYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG
FARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFA
TNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ
PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV
EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII
TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIG
AFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYS
RHRLVPLLDRPFDETTYEETED

# Metabolic_Enzyme_10_Number_of_Residues:
562

# Metabolic_Enzyme_10_Molecular_Weight:
62925

# Metabolic_Enzyme_10_Theoretical_pI:
7.85

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D- sphinganine + CO(2)

# Metabolic_Enzyme_10_Pathway:
map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_10_Reaction:
palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
67-87

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.3.1.50

# Metabolic_Enzyme_10_GenBank_ID_Protein:
2564249

# Metabolic_Enzyme_10_SwissProt_ID:
LCB2_HUMAN (O15270)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
SPTLC2

# Metabolic_Enzyme_10_Geneatlas_id:
SPTLC2

# Metabolic_Enzyme_10_hgnc_id:
HGNC:11278

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein

# Metabolic_Enzyme_10_Gene_Sequence:
>1689 bp
ATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTG
GCGAACGGGGAAGTACGGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCC
GCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATAAAAGACCGTTTAAT
GAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTA
CTCACCCTCTTTGGATATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCAC
CATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATCAAGATTTTGAAAAC
TTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGT
GTGCCTGGAGCCAGGGTGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTC
AAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCTACAACTATCTTGGA
TTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGA
GCTGGAGTGTGCAGTACTCGGCAGGAAATTGGAAACCTGGACAAGCATGAAGAACTAGAG
GAGCTTGTAGCAAGGTTCTTAGGAGTAGAAGCTGCTATGGCGTATGGCATGGGATTTGCA
ACGAATTCAATGAACATTCCTGCTCTTGTTGGCAAAGGTTGCCTGATTCTGAGTGATGAA
CTGAACCATGCATCACTGGTTCTGGGAGCCAGACTGTCAGGAGCAACCATTAGAATCTTC
AAACACAACAATATGCAAAGCCTAGAGAAGCTATTGAAAGATGCCATTGTTTATGGTCAG
CCTCGGACACGAAGGCCCTGGAAGAAAATTCTCATCCTTGTGGAAGGAATATATAGCATG
GAGGGATCTATTGTTCGTCTTCCTGAAGTGATTGCCCTCAAGAAGAAATACAAGGCATAC
TTGTATCTGGATGAGGCTCACAGCATTGGCGCCCTGGGCCCCACAGGCCGGGGTGTGGTG
GAGTACTTTGGCCTGGATCCCGAGGATGTGGATGTTATGATGGGAACGTTCACAAAGAGT
TTTGGTGCTTCTGGAGGATATATTGGAGGCAAGAAGGAGCTGATAGACTACCTGCGAACA
CATTCTCATAGTGCAGTGTATGCCACGTCATTGTCACCTCCTGTAGTGGAGCAGATCATC
ACCTCCATGAAGTGCATCATGGGGCAGGATGGCACCAGCCTTGGTAAAGAGTGTGTACAA
CAGTTAGCTGAAAACACCAGGTATTTCAGGAGACGCCTGAAAGAGATGGGCTTCATCATC
TATGGAAATGAAGACTCTCCAGTAGTGCCTTTGATGCTCTACATGCCTGCCAAAATTGGC
GCCTTTGGACGGGAGATGCTGAAGCGGAACATCGGTGTCGTTGTGGTTGGATTTCCTGCC
ACCCCAATTATTGAGTCCAGAGCCAGGTTTTGCCTGTCAGCAGCTCATACCAAAGAAATA
CTTGATACTGCTTTAAAGGAGATAGATGAAGTTGGGGACCTATTGCAGCTGAAGTATTCC
CGTCATCGGTTGGTACCTCTACTGGACAGGCCCTTTGACGAGACGACGTATGAAGAAACA
GAAGACTGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
Y08686

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_10_Locus:
14q24.3-q31

# Metabolic_Enzyme_10_SNPs:
rs9323646; rs2364602; rs34418677; rs10132095; rs11159268; rs11159269; rs1063271; rs10147023; rs9323644; rs2364160; rs1063270; rs17824567; rs17751562; rs2267750; rs2886132; rs1474504; rs2299921; rs2267749; rs2299927; rs2267746; rs2142187; rs1861942; rs2284229; rs741850; rs10129280; rs1997562; rs2299922; rs8003639; rs1990806; rs10132804; rs2299913; rs2364578; rs11159273; rs176895; rs7145386; rs1554957; rs2272589; rs8003812; rs10873309; rs176894; rs1997561; rs10147810; rs2142185; rs6574383; rs4903612; rs10135955; rs2272588; rs2299924; rs12147112; rs2299919; rs4899659; rs3101; rs4899660; rs714377; rs2299923; rs176896; rs9972134; rs176901; rs11623643; rs4903610; rs4903591; rs12433198; rs7157767; rs17824646; rs4145508; rs10146062; rs17824984; rs2299928; rs11623595; rs10142919; rs11629330; rs11159279; rs12878099; rs7159486; rs2142186; rs10140195; rs2299920; rs2364603; rs7147867; rs12588462; rs10151712; rs4903602; rs2267747; rs17751692; rs7145669; rs10151907; rs2886131; rs1534834; rs2178875; rs11621931; rs4903590; rs17106022; rs2299912; rs11626728; rs9323645; rs7145619; rs11847977; rs176903; rs13379058; rs11624959; rs2299926; rs176907; rs2299915; rs4903598; rs2178876; rs2284230; rs4903606; rs17751746; rs11851777; rs17105949; rs4243656; rs4497612; rs7160438; rs11159275; rs7154707; rs2299929; rs2299911; rs10139421; rs12435993; rs8014527; rs926114; rs17751993; rs926115; rs12433321; rs7143656; rs12589478; rs17105930; rs12897996; rs10139059; rs11159280; rs12436626; rs11159276; rs2272587; rs10873307; rs11159281; rs2267748; rs176905; rs11846597; rs9944097; rs4903609; rs12590866; rs11851805; rs17825014; rs7157643; rs17106085; rs4903607; rs11623225; rs2299917; rs11622277; rs11159278; rs12101129; rs8021327; rs176904; rs11846793; rs7155181; rs2003633; rs7158568; rs1967637; rs12879719; rs4899661; rs11847969; rs8018783; rs7157536; rs8017338; rs11627714; rs7157356; rs4903614; rs7400794; rs10873308; rs4899657; rs4903596; rs12892168; rs7152099; rs11849629; rs11159270; rs6574381; rs11847023; rs2364601; rs2178874; rs11621005; rs11844390; rs10400797; rs7401948; rs8011528; rs8014656; rs11626688; rs963897; rs8022687; rs11852065; rs11627851; rs4903611; rs17824742; rs176906; rs12434746; rs1554956; rs11849902; rs12100991; rs10143360; rs4903595; rs17752117; rs8021660; rs176897; rs17105954; rs8022582; rs2299910; rs10146161; rs10147781; rs7156939; rs17105922; rs12436428; rs11623114; rs4903601; rs17106092; rs8019658; rs10142516; rs8023132; rs12897006; rs8021434; rs17751727; rs17751923; rs12432164; rs9323647; rs10131773; rs12589986; rs10151047; rs8020860; rs8022045; rs17751644; rs4903604; rs17751917; rs17105963; rs17824754; rs2091914; rs8021200; rs7158771; rs17751889; rs8008258; rs2267754; rs10151331; rs8003293; rs7160005; rs11625066; rs12884431; rs7145694; rs11850680; rs17751980; rs10140616; rs17105989; rs10132412; rs11846516; rs6574379; rs11850485; rs12586959; rs12431511; rs10139852; rs741848; rs12433414; rs4903603; rs7147206; rs2012998; rs17106068; rs9796495; rs7401985; rs17105935; rs2072672; rs8021585; rs2364579; rs11159277; rs7159334; rs8018812; rs2267751; rs176898; rs4903597; rs10137398; rs7144024; rs2299925; rs11159272; rs12436583; rs4903605; rs7401921; rs17105952; rs8003771; rs2142183; rs11620740; rs12434055; rs7146600; rs17751876; rs4903593; rs12587835; rs8021376; rs7157146; rs176899; rs10132918; rs10140715; rs12586884; rs12433737; rs10149237; rs12433742; rs17105886; rs8021886; rs8010934; rs4903589; rs7155602; rs34830263; rs34017190; rs1048382; rs1063269; rs7155278; rs34610289; rs1140241; rs35710555; rs7151451; rs10144006; rs28419564; rs28628100; rs767519; rs34550571; rs7156665; rs10711146; rs34211836; rs11270440; rs28461747; rs28534926; rs7157122; rs36088012; rs34909725; rs35935659; rs41347855; rs6574385; rs35707793; rs8022297; rs36063635; rs35502477; rs35521627; rs3831726; rs28463433; rs11301610; rs34050122; rs10669360; rs34363127; rs4903613; rs35817034; rs2091915; rs17824700; rs34677114; rs12895694; rs28688083; rs34294932; rs11849669; rs8004422; rs11410784; rs34139376; rs35487377; rs5809838; rs35894415; rs10136825; rs34335254; rs11439888; rs34320971; rs35452362; rs34614143; rs35105418; rs3837646; rs34812822; rs28457661; rs34359219; rs10709892; rs34278364; rs34693965; rs36225518; rs1882835; rs3075857; rs10145028; rs7153567; rs7156954; rs35395128; rs34780790; rs11402118; rs35543276; rs12432243; rs36058499; rs12880891; rs28698404; rs3080460; rs2299918; rs11306515; rs35829532; rs28393685; rs34111263; rs34158839; rs11439890; rs3783984; rs2299916; rs28714070; rs4903599; rs11342711; rs11621440; rs35307713; rs34443115; rs28771140; rs34526449; rs34755405; rs3831725; rs28670354; rs11434567; rs2037931; rs11849670; rs11293169; rs11622425; rs11452479; rs176900; rs34185270; rs28628604; rs10562305; rs12886893; rs34670650; rs34946679; rs28677959; rs11312496; rs34116550; rs12148048; rs8020216; rs36228978; rs35379737; rs10595386; rs35640441; rs28719093; rs33974686; rs35513319; rs10627978; rs35769140; rs36072205; rs12882054; rs10573329; rs35591983; rs28716286; rs10133381; rs28612799; rs28527479; rs12434586; rs34703325; rs36100409; rs28729664; rs34448670; rs10145039; rs34063133; rs10151175; rs9707660; rs10438172; rs11424201; rs35256374; rs35336866; rs7159082; rs35209022; rs28516852; rs35893191; rs34036954; rs10141124; rs34516530; rs12588876; rs35774280; rs35380519; rs36111947; rs34174438; rs11410068; rs11344772; rs28709464; rs34274132; rs10595387; rs11410783; rs3080458; rs11447420; rs4362325; rs35055049; rs36087477; rs733473; rs12147041; rs34826872; rs35139171; rs10537544; rs36009978; rs34648938; rs35500816; rs3080466; rs35001639; rs7157220; rs33949316; rs33916744; rs12886936; rs3216475; rs10151925; rs28758456; rs12896893; rs34550215; rs11400711; rs8018049; rs9635267; rs33949600; rs11347331; rs12437425; rs35429209; rs34451515; rs28708472; rs28806494; rs34847653; rs3216477; rs34421039; rs8010591; rs28514654; rs10624624; rs6574380; rs10145025; rs34347805; rs12886457; rs28584839; rs34835614; rs28668365; rs12895679; rs28676801; rs8018813; rs35112343; rs11322822; rs33989448; rs34467614; rs35046491; rs176902; rs11626949; rs4325486; rs35083774; rs34883042; rs35245045; rs1969599; rs35844252; rs28571952; rs2142184; rs10711715; rs34114296; rs34130273; rs733472; rs10147878; rs28482839; rs28472502; rs28628767; rs10717655; rs11462095; rs7154342; rs3216478; rs12883503; rs10145026; rs11431131; rs7492541; rs2886130; rs4286042; rs35192294; rs9806055; rs34189517; rs8004174; rs10144781; rs10711147; rs12889681; rs10523096; rs5809840; rs11413257; rs35256162; rs34100991; rs35762082; rs12101243; rs35223746; rs28584952; rs35514400; rs2178877; rs10148189; rs10542182; rs10145035; rs28465487; rs35406693; rs9972150; rs34153615; rs10668423; rs10679913; rs4903594; rs12885003; rs11427941; rs35366076; rs34500527; rs28729229; rs35119760; rs34265939; rs11412876; rs12887526; rs10679912; rs35044256; rs10583251; rs12886702; rs28406314; rs34935836; rs34867638; rs4903592; rs35647237; rs12896679; rs36119437; rs2299914; rs35044584; rs35286116; rs35178083; rs12885954; rs10568711; rs3080470; rs28460392; rs35086251; rs28662942; rs35720628; rs34321996; rs33946938; rs3216476; rs28540783; rs7159683; rs10136221; rs10150525; rs2267745; rs12896678; rs35570539; rs12886903; rs5809839; rs10577703; rs35228068; rs6145397; rs34350628; rs34663034; rs34750410; rs34602192; rs35779417; rs6574382; rs8010191; rs33985522; rs11625310; rs12891514; rs35519357; rs10711714; rs12101160; rs7153686; rs34084166; rs9972120; rs4899658; rs28608714; rs35655996; rs4903600; rs35015300; rs36002798; rs12895283; rs28654332; rs34751874; rs12586167; rs4997242; rs35580409; rs34201644; rs12897408; rs10565854; rs34045378; rs28379508; rs35922322; rs34700249; rs10610860; rs35964784; rs35928833; rs1973866; rs28737290; rs7401267; rs35503744; rs28417590; rs35299313; rs34614752; rs13430; rs2284231; rs12434469; rs3742726; rs12323555; rs34517200; rs1053987; rs12432624; rs11558514; rs11844772; rs11845884; rs11851856; rs12431896; rs12434449; rs12881338; rs12887556; rs176908; rs176910; rs17752135; rs17752165; rs2037933; rs3742727; rs4243658; rs4899664; rs6574378; rs8003820; rs8004601; rs8007669; rs8010250; rs8017995

# Metabolic_Enzyme_10_General_References:
9363775; 9628581; 12508121; 8921873; 7506601

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
8622

# Metabolic_Enzyme_11_Name:
L-3-phosphoserine-phosphatase homologue

# Metabolic_Enzyme_11_Synonyms:
Not Available

# Metabolic_Enzyme_11_Gene_Name:
PSPHL

# Metabolic_Enzyme_11_Protein_Sequence:
>L3phosphoserinephosphatase homologue
MASASCSPGGALASPEPGRKILPRMISHSELRKLFYSADAVCFDVDSTVISEEGIGCFHW
IWRKCDQATSQG

# Metabolic_Enzyme_11_Number_of_Residues:
72

# Metabolic_Enzyme_11_Molecular_Weight:
7804

# Metabolic_Enzyme_11_Theoretical_pI:
6.48

# Metabolic_Enzyme_11_GO_Classification:
Not Available

# Metabolic_Enzyme_11_General_Function:
Not Available

# Metabolic_Enzyme_11_Specific_Function:
Not Available

# Metabolic_Enzyme_11_Pathway:
Not Available

# Metabolic_Enzyme_11_Reaction:
Not Available

# Metabolic_Enzyme_11_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_11_Signals:
Not Available

# Metabolic_Enzyme_11_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 3.1.3.3

# Metabolic_Enzyme_11_GenBank_ID_Protein:
2407909

# Metabolic_Enzyme_11_SwissProt_ID:
O15172_HUMAN (O15172)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
PSPHL

# Metabolic_Enzyme_11_Geneatlas_id:
PSPHL

# Metabolic_Enzyme_11_hgnc_id:
HGNC:9578

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Not Available

# Metabolic_Enzyme_11_Gene_Sequence:
>219 bp
ATGGCCAGCGCCAGCTGCAGCCCCGGCGGCGCACTCGCCTCACCTGAGCCTGGGAGGAAA
ATTCTTCCAAGGATGATCTCCCACTCAGAGCTGAGGAAGCTTTTCTACTCAGCAGATGCT
GTGTGTTTTGATGTTGACAGCACGGTCATCAGTGAAGAAGGAATCGGATGCTTTCATTGG
ATTTGGAGGAAATGTGATCAGGCAACAAGTCAAGGATAA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
AJ001612

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_11_Locus:
7q11.2

# Metabolic_Enzyme_11_SNPs:
Not Available

# Metabolic_Enzyme_11_General_References:
9573387

# Metabolic_Enzyme_11_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8475

# Macromolecular_Interacting_Partner_1_Name:
Phosphatidylserine synthase 2

# Macromolecular_Interacting_Partner_1_Synonyms:
PtdSer synthase 2; PSS-2; Serine-exchange enzyme II

# Macromolecular_Interacting_Partner_1_Gene_Name:
PTDSS2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Phosphatidylserine synthase 2
MRRGERRDAGGPRPESPVPAGRASLEEPPDGPSAGQATGPGEGRRSTESEVYDDGTNTFF
WRAHTLTVLFILTCTLGYVTLLEETPQDTAYNTKRGIVASILVFLCFGVTQAKDGPFSRP
HPAYWRFWLCVSVVYELFLIFILFQTVQDGRQFLKYVDPKLGVPLPERDYGGNCLIYDPD
NETDPFHNIWDKLDGFVPAHFLGWYLKTLMIRDWWMCMIISVMFEFLEYSLEHQLPNFSE
CWWDHWIMDVLVCNGLGIYCGMKTLEWLSLKTYKWQGLWNIPTYKGKMKRIAFQFTPYSW
VRFEWKPASSLRRWLAVCGIILVFLLAELNTFYLKFVLWMPPEHYLVLLRLVFFVNVGGV
AMREIYDFMDDPKPHKKLGPQAWLVAAITATELLIVVKYDPHTLTLSLPFYISQCWTLGS
VLALTWTVWRFFLRDITLRYKETRWQKWQNKDDQGSTVGNGDQHPLGLDEDLLGPGVAEG
EGAPTPN

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
487

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
56253

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.19

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
 Function:  Not Available
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  phospholipid metabolism
Process:  glycerophospholipid metabolism
Process:  phosphatidylserine metabolism
Process:  phosphatidylserine biosynthesis
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF03034:PSS

# Macromolecular_Interacting_Partner_1_Signals:
Not Available

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
63-83
97-117
127-147
242-262
314-334
336-356
377-397
404-424

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
21740008

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
PTSS2_HUMAN (Q9BVG9)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
PTDSS2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
PTDSS2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:15463

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1464 bp
ATGCGGAGGGGCGAGCGCAGGGACGCCGGAGGTCCGCGGCCCGAGTCCCCGGTGCCCGCG
GGCAGGGCCTCGCTGGAGGAGCCGCCTGACGGGCCGTCTGCCGGCCAAGCCACCGGGCCG
GGCGAGGGCCGCCGCAGCACCGAGTCCGAGGTCTACGACGACGGCACCAACACCTTCTTC
TGGCGAGCCCACACCTTAACCGTGCTCTTCATCCTCACCTGTACGCTTGGCTATGTGACG
CTGCTGGAGGAAACACCTCAGGACACGGCCTACAACACCAAGAGAGGTATTGTGGCCAGT
ATTTTGGTTTTCTTATGTTTTGGAGTCACACAAGCTAAAGACGGGCCATTTTCCAGACCT
CATCCAGCTTACTGGAGGTTTTGGCTCTGCGTGAGTGTGGTCTACGAGCTGTTTCTCATC
TTTATACTCTTCCAGACTGTCCAGGACGGCCGGCAGTTTCTAAAGTATGTTGACCCCAAG
CTGGGAGTCCCACTGCCAGAGAGAGACTACGGGGGAAACTGCCTCATCTACGACCCAGAC
AATGAGACTGACCCCTTTCACAACATCTGGGACAAGTTGGATGGCTTTGTTCCCGCGCAC
TTTCTTGGCTGGTACCTGAAGACCCTGATGATCCGAGACTGGTGGATGTGCATGATCATC
AGCGTGATGTTCGAGTTCCTGGAGTACAGCCTGGAGCACCAGCTGCCCAACTTCAGCGAG
TGCTGGTGGGATCACTGGATCATGGACGTGCTCGTCTGCAACGGGCTGGGCATCTACTGC
GGCATGAAGACCCTTGAGTGGCTGTCCCTGAAGACGTACAAGTGGCAGGGCCTCTGGAAC
ATTCCGACCTACAAGGGCAAGATGAAGAGGATCGCCTTCCAGTTCACGCCGTACAGCTGG
GTTCGCTTCGAGTGGAAGCCGGCCTCCAGCCTGCGTCGCTGGCTGGCCGTGTGCGGCATC
ATCCTGGTGTTCCTGTTGGCAGAACTGAACACGTTCTACCTGAAGTTTGTGCTGTGGATG
CCCCCGGAGCACTACCTGGTCCTCCTGCGGCTCGTCTTCTTCGTGAACGTGGGTGGCGTG
GCCATGCGTGAGATCTACGACTTCATGGATGACCCGAAGCCCCACAAGAAGCTGGGCCCG
CAGGCCTGGCTGGTGGCGGCCATCACGGCCACGGAGCTGCTCATCGTGGTGAAGTACGAC
CCCCACACGCTCACCCTGTCCCTGCCCTTCTACATCTCCCAGTGCTGGACCCTCGGCTCC
GTCCTGGCGCTCACCTGGACCGTCTGGCGCTTCTTCCTGCGGGACATCACATTGAGGTAC
AAGGAGACCCGGTGGCAGAAGTGGCAGAACAAGGATGACCAGGGCAGCACCGTCGGCAAC
GGGGACCAGCACCCACTGGGGCTGGACGAAGACCTGCTGGGGCCTGGGGTGGCCGAGGGC
GAGGGAGCACCAACTCCAAACTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AL834357

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11p15

# Macromolecular_Interacting_Partner_1_SNPs:
rs1044707; rs7121599; rs6598017; rs7935013; rs7940821; rs767086; rs7931534; rs3888797; rs2613996; rs11823647; rs7945673; rs7950520; rs6598016; rs11246164; rs7925484; rs9667049; rs12799388; rs7118621; rs11821392; rs9666582; rs11825931; rs9667303; rs7108959; rs11821341; rs4963194; rs7127967; rs12418639; rs7937939; rs9328565; rs4963139; rs7925729; rs7949115; rs9795283; rs12576945; rs7928814; rs2301172; rs4963135; rs7110400; rs6598018; rs2856239; rs7117853; rs7942404; rs12803629; rs12798676; rs7935018; rs7939891; rs4963138; rs12790188; rs12576322; rs9736326; rs7941276; rs7937085; rs7945922; rs7939892; rs211520; rs12807886; rs12417570; rs7940939; rs9795284; rs12806187; rs17155870; rs12803838; rs7113255; rs12575419; rs11602898; rs12794284; rs7394670; rs7101861; rs7482616; rs11539812; rs34809643; rs11539813; rs11539814; rs11600323; rs11539815; rs9736719; rs2301169; rs10698834; rs35716989; rs34585513; rs36058901; rs11821959; rs1056506; rs7103786; rs34083507; rs176938; rs9795451; rs12798512; rs35311379; rs35068485; rs7105294; rs4963196; rs2301171; rs7127572; rs172441; rs12099377; rs12099375; rs34665187; rs211531; rs10698835; rs35898083; rs211521; rs3082636; rs11820122; rs7945914; rs36117472; rs7115664; rs34612778; rs35669491; rs12804384; rs7109207; rs7105974; rs11602979; rs10615411; rs34340365; rs211530; rs34831699; rs211522; rs34836032; rs35908275; rs4963195; rs34385146; rs3216784; rs12223359; rs36051705; rs34519965; rs11821447; rs12275194; rs211532; rs12798758; rs35275997; rs9667879; rs10128578; rs9794846; rs11822000; rs12417681; rs35683840; rs35323970; rs35906014; rs10698836; rs211529; rs28591970; rs34255371; rs34645733; rs34526529; rs2301168; rs12574094; rs12363435; rs4963193; rs11821448; rs11823439; rs34876950; rs35389167; rs7108364; rs10698837; rs36108966; rs7931053; rs2301170; rs35996687; rs7947963; rs12280302; rs7123715; rs7110722; rs12362713; rs12803626; rs35375490; rs34720250; rs33967553; rs35859071; rs6598019; rs1049499; rs10540; rs11246165; rs11246166; rs11607572; rs11825121; rs12417451; rs12419209; rs17584; rs17585; rs176939; rs211526; rs211527; rs3177784; rs34136715; rs35608427; rs35800583; rs35811812; rs36001698; rs36042148; rs3781612; rs3868121; rs3868122; rs3868123; rs3895648; rs4963190; rs6598020; rs7113204; rs7118425; rs7131513; rs7924341; rs7933587; rs7983

# Macromolecular_Interacting_Partner_1_General_References:
Not Available

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8479

# Macromolecular_Interacting_Partner_2_Name:
Asc-type amino acid transporter 1

# Macromolecular_Interacting_Partner_2_Synonyms:
Asc-1

# Macromolecular_Interacting_Partner_2_Gene_Name:
SLC7A10

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Asctype amino acid transporter 1
MAGHTQQPSGRGNPRPAPSPSPVPGTVPGASERVALKKEIGLLSACTIIIGNIIGSGIFI
SPKGVLEHSGSVGLALFVWVLGGGVTALGSLCYAELGVAIPKSGGDYAYVTEIFGGLAGF
LLLWSAVLIMYPTSLAVISMTFSNYVLQPVFPNCIPPTTASRVLSMACLMLLTWVNSSSV
RWATRIQDMFTGGKLLALSLIIGVGLLQIFQGHFEELRPSNAFAFWMTPSVGHLALAFLQ
GSFAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELLSSN
AVAVTFGEKLLGYFSWVMPVSVALSTFGGINGYLFTYSRLCFSGAREGHLPSLLAMIHVR
HCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLLLRWRRPALHRPI
KVNLLIPVAYLVFWAFLLVFSFISEPMVCGVGVIIILTGVPIFFLGVFWRSKPKCVHRLT
ESMTHWGQELCFVVYPQDAPEEEENGPCPPSLLPATDKPSKPQ

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
523

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
56799

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
8.24

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_2_Specific_Function:
Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_2_Signals:
1-136

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
40-60
72-92
113-133
268-288
310-330
362-382
388-408
424-444
448-468

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
9309293

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
AAA1_HUMAN (Q9NS82)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
SLC7A10

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
SLC7A10

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:11058

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane; multi-pass membrane protein (Probable)

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1572 bp
ATGGCCGGCCACACGCAGCAGCCGAGCGGGCGCGGGAACCCCAGGCCTGCGCCCTCGCCC
TCCCCAGTCCCAGGGACCGTCCCCGGCGCCTCGGAGCGGGTGGCGCTCAAGAAGGAGATC
GGGCTGCTGAGCGCCTGCACCATCATCATCGGGAACATCATCGGCTCGGGCATCTTCATC
TCGCCCAAGGGGGTCCTGGAGCACTCAGGCTCCGTGGGTCTGGCCCTGTTCGTCTGGGTC
CTGGGTGGGGGCGTGACGGCTCTGGGCTCCCTCTGCTATGCAGAGCTGGGAGTCGCCATC
CCCAAGTCTGGCGGGGACTACGCCTACGTCACAGAGATCTTCGGGGGCCTGGCTGGCTTT
CTGCTGCTCTGGAGCGCCGTCCTCATCATGTACCCCACCAGCCTTGCTGTCATCTCCATG
ACCTTCTCCAACTACGTGCTGCAGCCCGTGTTCCCCAACTGCATCCCCCCCACCACAGCC
TCCCGGGTGCTGTCCATGGCCTGCCTGATGCTCCTGACATGGGTGAACAGCTCCAGTGTG
CGCTGGGCCACGCGCATCCAGGACATGTTCACAGGCGGGAAGCTGCTGGCCTTGTCCCTC
ATCATCGGCGTGGGCCTTCTCCAGATCTTCCAAGGACACTTCGAGGAGCTGAGGCCCAGC
AATGCCTTTGCTTTCTGGATGACGCCCTCCGTGGGACACCTGGCCCTGGCCTTCCTCCAG
GGCTCCTTCGCCTTCAGTGGCTGGAACTTCCTCAACTATGTCACCGAGGAGATGGTTGAC
GCCCGAAAGAACCTACCTCGCGCCATCTTCATCTCCATCCCACTGGTGACCTTCGTGTAC
ACGTTCACCAACATTGCCTACTTCACGGCCATGTCCCCCCAGGAGCTGCTCTCCTCCAAT
GCGGTGGCTGTGACCTTCGGGGAGAAGCTGCTGGGCTACTTTTCTTGGGTCATGCCTGTC
TCCGTGGCTCTGTCAACCTTCGGAGGGATCAATGGTTACCTGTTCACCTACTCCAGGCTG
TGCTTCTCTGGAGCCCGCGAGGGGCACCTGCCCAGCCTGCTGGCCATGATCCACGTCAGA
CACTGCACCCCCATCCCCGCCCTCCTCGTCTGTTGCGGGGCCACAGCCGTCATCATGCTC
GTGGGCGACACGTACACGCTCATCAACTATGTGTCCTTCATCAACTACCTCTGCTACGGC
GTCACCATCCTGGGCCTGCTGCTGCTGCGCTGGAGGCGGCCTGCACTCCACAGGCCCATC
AAGGTGAACCTTCTCATCCCCGTGGCGTACTTGGTCTTCTGGGCCTTCCTGCTGGTCTTC
AGCTTCATCTCAGAGCCTATGGTCTGTGGGGTCGGCGTCATCATCATCCTTACGGGGGTG
CCCATTTTCTTTCTGGGAGTGTTCTGGAGAAGCAAACCAAAGTGTGTGCACAGACTCACA
GAGTCCATGACACACTGGGGCCAGGAGCTGTGTTTCGTGGTCTACCCCCAGGACGCCCCC
GAAGAGGAGGAGAATGGCCCCTGCCCACCCTCCCTGCTGCCTGCCACAGACAAGCCCTCG
AAGCCACAATGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AB037670

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_2_Locus:
19q13.1

# Macromolecular_Interacting_Partner_2_SNPs:
rs34663170; rs2303094; rs4805031; rs7258412; rs12609177; rs8106493; rs1974807; rs10406787; rs8101891; rs7254894; rs12609763; rs7508758; rs3786926; rs2303093; rs8106375; rs4407170; rs3786927; rs2241378; rs8105889; rs11669156; rs1009175; rs11673535; rs16967863; rs11671790; rs34454261; rs8105887; rs12972369; rs11084715; rs4805030; rs4516343; rs8110876; rs35557280; rs16967861; rs12972468; rs11878801; rs11666788; rs10417375; rs726822; rs1465424; rs4330029; rs4553741; rs7251684; rs889102; rs7249980; rs35390810; rs11542481; rs34961684; rs8107888; rs12151336; rs11670702; rs34937345; rs34203180; rs889101; rs34180473; rs10555903; rs12982023; rs33951856; rs4805862; rs11882613; rs11879325; rs34981363; rs11378328; rs8107002; rs11880750; rs34309383; rs5827838; rs35763570; rs35887187; rs7248380; rs34843019; rs11455629; rs28419758; rs35055563; rs35775570; rs35756066; rs11671925; rs34257327; rs10667670; rs34645339; rs36212687; rs3064210; rs5827839; rs11448774; rs5827841; rs3064187; rs5827842; rs889103; rs36216474; rs10410558; rs10412342; rs1056034; rs1056041; rs1107920; rs1107921; rs11084712; rs11666900; rs11671345; rs11672303; rs11673115; rs1559182; rs17694094; rs17760699; rs17848212; rs1862464; rs2112800; rs2194169; rs2303095; rs2303096; rs34138351; rs34158692; rs34529542; rs35831673; rs36029918; rs3745974; rs3745975; rs3745976; rs3745977; rs3745978; rs4444444; rs4805863; rs7359893; rs8100642; rs875550

# Macromolecular_Interacting_Partner_2_General_References:
10863037; 11509015

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8594

# Macromolecular_Interacting_Partner_3_Name:
SLC38A2 protein

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC38A2

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>SLC38A2 protein
MKQNLILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIG
AMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGY
TSGLSLLCMVFFLIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDS
CRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYL
LAALFGYLTFYEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTH
LLCASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIK
LVKKEPMKSVQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
406

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
45180

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
8.88

# Macromolecular_Interacting_Partner_3_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_3_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_3_Signals:
1-18

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
5-23; 48-69; 89-111; 115-137; 230-252; 272-294; 315-334; 339-361; 373-395

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
Q6IA88_HUMAN (Q6IA88)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC38A2

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC38A2

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:13448

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
CR457267

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_3_Locus:
12q

# Macromolecular_Interacting_Partner_3_SNPs:
rs10880961; rs7968283; rs956910; rs2897968; rs7968173; rs7961994; rs10880959; rs2307063; rs1873793; rs3742061; rs2307061; rs10880960; rs3782904; rs7965930; rs2307062; rs2279559; rs7974529; rs7960147; rs10785624; rs11183450; rs34139863; rs36065261; rs36022751; rs11340856; rs7966787; rs11313787; rs5797976; rs1046296; rs11183449; rs12307969; rs2307060; rs36019260; rs3837525; rs35534621; rs11183447; rs3832874; rs3830356; rs34489723; rs36066221; rs11298796; rs7295472; rs35732850; rs35944767; rs34099989; rs10880962; rs11183446; rs12368989; rs1492896; rs17096884; rs4768697; rs4768698; rs7135630; rs7967840; rs7975820; rs7979418

# Macromolecular_Interacting_Partner_3_General_References:
Not Available

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8607

# Macromolecular_Interacting_Partner_4_Name:
SLC38A5 protein

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC38A5

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>SLC38A5 protein
SIHLLLTCAGIAGIRAYEQLGQRAFGPAGKVVVATVICLHNVGAMSSYLFIIKSELPLVI
GTFLYMDPEGDWFLKGNLLIIIVSVLIILPLALMKHLGYLGYTSGLSLTCMLFFLVSVIY
KKFQLGCAIGHNETAMESEALVGLPSQGLNSSCEAQMFTVDSQMSYTVPIMAFAFVCHPE
VLPIYTELCRPSKRRMQAVANVSIGAMFCMYGLTATFGYLTFYSSVKAEMLHMYSQKDPL
ILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPGKAFSWPRHVAIALILLVLVNVLVICV
PTIRDIFGVIGSTSAPSLIFILPSIFYLRIVPSEVEPFLSWPKIQALCFGVLGVLFMAVS
LGFMFANWATGQSRMSGH

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
378

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
41426

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.47

# Macromolecular_Interacting_Partner_4_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_4_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_4_Signals:
1-16

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
31-52; 72-94; 98-120; 166-188; 198-220; 241-263; 278-300; 307-329; 344-366

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
40225675

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
Q6PIW9_HUMAN (Q6PIW9)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC38A5

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC38A5

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:18070

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1138 bp
CTCCATCCACCTCCTGCTGACCTGTGCTGGTATTGCAGGCATCCGAGCCTATGAGCAGCT
GGGACAGAGGGCATTCGGGCCTGCGGGGAAGGTAGTGGTGGCCACAGTCATCTGTCTGCA
CAATGTTGGGGCCATGTCCAGTTACCTGTTCATCATCAAATCTGAGCTCCCCCTGGTTAT
CGGCACCTTCCTGTACATGGACCCCGAGGGGGACTGGTTCTTGAAGGGAAACCTCCTCAT
CATCATCGTCAGTGTGTTAATCATCCTGCCCCTCGCCCTCATGAAACACTTGGGCTACCT
GGGGTACACCAGTGGTCTCTCTCTGACCTGCATGCTGTTTTTCCTTGTTTCGGTCATCTA
CAAGAAGTTCCAACTTGGCTGTGCTATAGGCCACAATGAAACAGCAATGGAGAGTGAAGC
TCTCGTGGGACTCCCCAGCCAAGGACTCAACAGCAGCTGTGAGGCCCAGATGTTCACAGT
TGACTCACAGATGTCCTACACAGTGCCCATTATGGCTTTTGCTTTTGTCTGCCACCCTGA
GGTGCTGCCCATCTATACGGAGCTCTGCCGGCCCTCCAAGCGCAGGATGCAGGCCGTGGC
CAACGTGTCCATTGGGGCCATGTTCTGCATGTATGGGCTCACAGCAACCTTTGGATACCT
CACCTTCTACAGCAGTGTGAAGGCGGAGATGCTGCACATGTACAGCCAGAAGGACCCGCT
CATCCTCTGTGTGCGCCTGGCCGTGCTGCTCGCGGTGACCCTCACTGTGCCAGTCGTGCT
GTTCCCTATCCGCCGGGCCCTGCAGCAGCTGCTTTTCCCAGGCAAGGCCTTCAGCTGGCC
ACGACATGTGGCCATAGCTCTGATCCTGCTTGTTTTGGTCAATGTCCTTGTCATCTGTGT
GCCAACCATCCGGGATATCTTTGGAGTTATCGGGTCCACCTCAGCCCCCAGCCTCATCTT
CATCCTCCCCAGCATCTTCTACCTCCGCATTGTACCCTCTGAGGTGGAGCCTTTCTTATC
CTGGCCCAAGATCCAGGCCCTGTGCTTTGGAGTCCTGGGAGTCCTCTTCATGGCCGTCAG
TCTAGGCTTTATGTTTGCCAACTGGGCCACAGGCCAGAGCCGCATGTCTGGACACTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
BC027721

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_4_Locus:
Xp11.23

# Macromolecular_Interacting_Partner_4_SNPs:
rs17281188; rs2293953; rs2293952; rs909322; rs12014551; rs5905691; rs2272657; rs5906670; rs17148207; rs34099520; rs12851533; rs5906672; rs12851546; rs12838813; rs6608806; rs34145896; rs28469063; rs10671203; rs4988523; rs35633286; rs35982043; rs4988522; rs2293951; rs5902424; rs5906671; rs5902425; rs35863886; rs10577901; rs4480243; rs34884148; rs10578218; rs5953238; rs34820839; rs3840968; rs10533882; rs1040344; rs12840106; rs2268954; rs2977590; rs2977591; rs4824714; rs5952506; rs7876401

# Macromolecular_Interacting_Partner_4_General_References:
12477932

# Macromolecular_Interacting_Partner_4_References:
Not Available

# Macromolecular_Interacting_Partner_5_ID:
8616

# Macromolecular_Interacting_Partner_5_Name:
Y+L amino acid transporter 1

# Macromolecular_Interacting_Partner_5_Synonyms:
y(+L-type amino acid transporter 1; y+LAT-1; Y+LAT1; Monocyte amino acid permease 2; MOP-2

# Macromolecular_Interacting_Partner_5_Gene_Name:
SLC7A7

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Y+L amino acid transporter 1
MVDSTEYEVASQPEVETSPLGDGASPGPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPK
GVLIYSASFGLSLVIWAVGGLFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRL
WTSLLIIEPTSQAIIAITFANYMVQPLFPSCFAPYAASRLLAAACICLLTFINCAYVKWG
TLVQDIFTYAKVLALIAVIVAGIVRLGQGASTHFENSFEGSSFAVGDIALALYSALFSYS
GWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYTVLDMRDILASDAVAVTF
ADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGHLPDAICMIHVERFTPVP
SLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWKEPDRPRPLKLSVFF
PIVFCLCTIFLVAVPLYSDTINSLIGIAIALSGLPFYFLIIRVPEHKRPLYLRRIVGSAT
RYLQVLCMSVAAEMDLEDGGEMPKQRDPKSN

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
511

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
55991

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
5.07

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
 Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_5_Specific_Function:
Sodium-independent exchanger of cationic and large neutral amino acids

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_5_Signals:
Not Available

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
37-57
69-89
107-127
133-153
160-180
186-206
222-242
259-279
304-324
383-403
416-436
441-461

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
4581435

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
YLA1_HUMAN (Q9UM01)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
SLC7A7

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
SLC7A7

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:11065

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Membrane; multi-pass membrane protein (Probable)

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1536 bp
ATGGTTGACAGCACTGAGTATGAAGTGGCCTCCCAGCCTGAGGTGGAAACCTCCCCTTTG
GGTGATGGGGCCAGCCCAGGGCCGGAGCAGGTGAAGCTGAAGAAGGAGATCTCACTGCTT
AACGGCGTGTGCCTGATTGTGGGGAACATGATCGGCTCAGGCATCTTTGTTTCCCCCAAG
GGTGTGCTCATATACAGTGCCTCCTTTGGTCTCTCTCTGGTCATCTGGGCTGTCGGGGGC
CTCTTCTCCGTCTTTGGGGCCCTTTGTTATGCGGAACTGGGCACCACCATTAAGAAATCT
GGGGCCAGCTATGCCTATATCCTGGAGGCCTTTGGAGGATTCCTTGCTTTCATCAGACTC
TGGACCTCCCTGCTCATCATTGAGCCCACCAGCCAGGCCATCATTGCCATCACCTTTGCC
AACTACATGGTACAGCCTCTCTTCCCGAGCTGCTTCGCCCCTTATGCTGCCAGCCGCCTG
CTGGCTGCTGCCTGCATCTGTCTCTTAACCTTCATTAACTGTGCCTATGTCAAATGGGGA
ACCCTGGTACAAGATATTTTCACCTATGCTAAAGTATTGGCACTGATCGCGGTCATCGTT
GCAGGCATTGTTAGACTTGGCCAGGGAGCCTCTACTCATTTTGAGAATTCCTTTGAGGGT
TCATCATTTGCAGTGGGTGACATTGCCCTGGCACTGTACTCAGCTCTGTTCTCCTACTCA
GGCTGGGACACCCTCAACTATGTCACTGAAGAGATCAAGAATCCTGAGAGGAACCTGCCC
CTCTCCATTGGCATCTCCATGCCCATTGTCACCATCATCTATATCTTGACCAATGTGGCC
TATTATACTGTGCTAGACATGAGAGACATCTTGGCCAGTGATGCTGTTGCTGTGACTTTT
GCAGATCAGATATTTGGAATATTTAACTGGATAATTCCACTGTCAGTTGCATTATCCTGT
TTTGGTGGCCTCAATGCCTCCATTGTGGCTGCTTCTAGGCTTTTCTTTGTGGGCTCAAGA
GAAGGCCATCTCCCTGATGCCATCTGCATGATCCATGTTGAGCGGTTCACACCAGTGCCT
TCTCTGCTCTTCAATGGTATCATGGCATTGATCTACTTGTGCGTGGAAGACATCTTCCAG
CTCATTAACTACTACAGCTTCAGCTACTGGTTCTTTGTGGGGCTTTCTATTGTGGGTCAG
CTTTATCTGCGCTGGAAGGAGCCTGATCGACCTCGTCCCCTCAAGCTCAGCGTTTTCTTC
CCGATTGTCTTCTGCCTCTGCACCATCTTCCTGGTGGCTGTTCCACTTTACAGTGATACT
ATCAACTCCCTCATCGGCATTGCCATTGCCCTCTCAGGCCTGCCCTTTTACTTCCTCATC
ATCAGAGTGCCAGAACATAAGCGACCGCTTTACCTCCGAAGGATCGTGGGGTCTGCCACA
AGGTACCTCCAGGTCCTGTGTATGTCAGTTGCTGCAGAAATGGATTTGGAAGATGGAGGA
GAGATGCCCAAGCAACGGGATCCCAAGTCTAACTAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
Y18474

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_5_Locus:
14q11.2

# Macromolecular_Interacting_Partner_5_SNPs:
rs11568438; rs1805061; rs8018462; rs1805059; rs1061040; rs8016634; rs12432242; rs3829407; rs7157654; rs2281677; rs2281678; rs28364570; rs8003565; rs3901112; rs6572756; rs7359123; rs12884337; rs5027249; rs7144493; rs12433985; rs3850290; rs8006783; rs10134338; rs8013531; rs6572755; rs8005577; rs4981440; rs6572770; rs7151065; rs11568434; rs4981441; rs2065134; rs6572754; rs8006959; rs4316670; rs8009463; rs8008860; rs4981439; rs8020146; rs2331772; rs8006372; rs2025210; rs17211943; rs9671631; rs17122346; rs3850291; rs11568430; rs4982676; rs12879369; rs8013199; rs11568429; rs17122403; rs8008775; rs2065047; rs11568422; rs10145612; rs3850293; rs11847310; rs3829406; rs11848632; rs4605074; rs4982679; rs7157097; rs9323209; rs8006353; rs7140366; rs10133276; rs4982675; rs17277879; rs8008926; rs17277872; rs12436190; rs3751485; rs4982671; rs12436256; rs17122349; rs1885402; rs11157832; rs2065135; rs2146231; rs10133059; rs4982673; rs8010165; rs2331714; rs8006930; rs3887870; rs6572752; rs7160295; rs12888930; rs7155516; rs8006101; rs3932495; rs10220286; rs10145846; rs10459445; rs11157819; rs7150679; rs2065044; rs7153183; rs10147613; rs4982677; rs11851289; rs8021277; rs9707487; rs2331766; rs8006068; rs10135949; rs7151696; rs7157118; rs4982674; rs17277865; rs4981438; rs12891079; rs10134386; rs11157817; rs10145611; rs2065045; rs11850787; rs10133893; rs7150667; rs3934209; rs4981442; rs10459444; rs2331769; rs10135074; rs11628750; rs2208654; rs12894685; rs2331765; rs2331771; rs8004437; rs12146987; rs3934210; rs7158333; rs11157833; rs7144397; rs8006653; rs2065046; rs8018436; rs8011806; rs11851258; rs7146300; rs2331768; rs1885591; rs2146232; rs7156633; rs12147201; rs17211950; rs11157836; rs11628748; rs11844141; rs17122385; rs4982681; rs8019656; rs10130540; rs1951567; rs10130537; rs11157810; rs10135803; rs11846392; rs10151126; rs1951566; rs4982680; rs1951568; rs1951565; rs1138286; rs1805062; rs35323339; rs34654418; rs28548972; rs28485487; rs10644590; rs28588397; rs28464162; rs35753892; rs28505834; rs8014410; rs35748274; rs12888481; rs28579848; rs8022688; rs35328728; rs2331770; rs10647286; rs10151071; rs10459505; rs34583396; rs33950544; rs28365818; rs35503839; rs179032; rs35500075; rs36202986; rs35434647; rs36215780; rs35718984; rs12888484; rs8017726; rs4424818; rs34641571; rs35045479; rs34757325; rs2331767; rs33944126; rs179035; rs33999733; rs34304860; rs36057907; rs10574852; rs179034; rs11455079; rs12880108; rs3076449; rs10702514; rs35398636; rs12881095; rs10672329; rs8016877; rs7144980; rs4982678; rs28621046; rs2065043; rs35629342; rs35758383; rs3932494; rs3076446; rs12892586; rs11361255; rs10595302; rs35326556; rs34452181; rs35358049; rs34293345; rs35203597; rs11157834; rs36096362; rs10135308; rs1272495; rs36089060; rs35256849; rs10132846; rs33936906; rs36110354; rs33953244; rs4609758; rs4505232; rs28582652; rs35698214; rs10131662; rs179029; rs3850292; rs12892596; rs35501308; rs10146190; rs10595226; rs33982413; rs2181225; rs7141545; rs12147763; rs3076435; rs28590479; rs179031; rs179037; rs12886178; rs35197287; rs28502733; rs35564703; rs12892590; rs1271268; rs1983763; rs11397219; rs10597441; rs7157698; rs7148931; rs34386018; rs35710053; rs12881341; rs28588189; rs12892438; rs1269411; rs10133977; rs34215169; rs11430909; rs34673895; rs35259168; rs8022679; rs179028; rs8003677; rs11395030; rs10459506; rs12882521; rs10654866; rs35209286; rs35316014; rs7161536; rs34308809; rs4533185; rs28494892; rs10459443; rs179033; rs4246997; rs10141489; rs34772384; rs17122373; rs35050152; rs35892962; rs28516981; rs179030; rs12147511; rs34783556; rs179036; rs33921335; rs28653553; rs34759644; rs10673088; rs34516291; rs35750898; rs35737812; rs35843252; rs35431366; rs34172127; rs8011966; rs34004476; rs7140363; rs8019970; rs6572753; rs7160130; rs34340570; rs34748469; rs35859509; rs28515861; rs34312187; rs34862252; rs34842713; rs36046611; rs33995868; rs28432732; rs33950046; rs4982682; rs34878142; rs35065113; rs33989244; rs35273567; rs35520878; rs34994757; rs4982683; rs10147193; rs10135815; rs28759095; rs5807190; rs28377776; rs10614809; rs34033212; rs7151287; rs10625308; rs35535229; rs10614808; rs10136960; rs11568423; rs11568425; rs11568426; rs11568427; rs11568428; rs11568431; rs11568432; rs11568435; rs11568436; rs12435744; rs17122772; rs17122776; rs17122779; rs17122782; rs17243007; rs17619; rs1957373; rs1957374; rs1957502; rs1957503; rs2073344; rs2073345; rs2075846; rs2284992; rs3087824; rs34237480; rs34453264; rs35143092; rs3764163; rs3764164; rs4981436; rs4981437; rs6572731; rs7150444; rs8572; rs8786; rs9323208

# Macromolecular_Interacting_Partner_5_General_References:
9829974; 9878049; 10080183; 10737982; 10631139; 10655553

# Macromolecular_Interacting_Partner_5_References:
Not Available

# Macromolecular_Interacting_Partner_6_ID:
8627

# Macromolecular_Interacting_Partner_6_Name:
4F2 cell-surface antigen heavy chain

# Macromolecular_Interacting_Partner_6_Synonyms:
4F2hc; Lymphocyte activation antigen 4F2 large subunit; 4F2 heavy chain antigen; CD98 antigen

# Macromolecular_Interacting_Partner_6_Gene_Name:
SLC3A2

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>4F2 cellsurface antigen heavy chain
MSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKF
TGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHT
GALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQID
PNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAG
VDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLT
SSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLP
GTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLS
LFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQAS
DLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYAA

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
529

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
57945

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
4.99

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  amylase activity
Function:  alpha-amylase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_6_Specific_Function:
Involved in sodium-independent, high-affinity transport of large neutral amino acids. Required for normal and neoplastic cell growth

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00128:Alpha-amylase

# Macromolecular_Interacting_Partner_6_Signals:
1-98

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
82-104

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
182865

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
4F2_HUMAN (P08195)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SLC3A2

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SLC3A2

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:11026

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1590 bp
ATGAGCCAGGACACCGAGGTGGATATGAAGGAGGTGGAGCTGAATGAGTTAGAGCCCGAG
AAGCAGCCGATGAACGCGGCGTCTGGGGCGGCCATGTCCCTGGCGGGAGCCGAGAAGAAT
GGTCTGGTGAAGATCAAGGTGGCGGAAGACGAGGCGGAGGCGGCAGCCGCGGCTAAGTTC
ACGGGCCTGTCCAAGGAGGAGCTGCTGAAGGTGGCAGGCAGCCCCGGCTGGGTACGCACC
CGCTGGGCACTGCTGCTGCTCTTCTGGCTCGGCTGGCTCGGCATGCTTGCTGGTGCCGTG
GTCATAATCGTGCGAGCGCCGCGTTGTCGCGAGCTACCGGCGCAGAAGTGGTGGCACACG
GGCGCCCTCTACCGCATCGGCGACCTTCAGGCCTTCCAGGGCCACGGCGCGGGCAACCTG
GCGGGTCTGAAGGGGCGTCTCGATTACCTGAGCTCTCTGAAGGTGAAGGGCCTTGTGCTG
GGTCCAATTCACAAGAACCAGAAGGATGATGTCGCTCAGACTGACTTGCTGCAGATCGAC
CCCAATTTTGGCTCCAAGGAAGATTTTGACAGTCTCTTGCAATCGGCTAAAAAAAAGAGC
ATCCGTGTCATTCTGGACCTTACTCCCAACTACCGGGGTGAGAACTCGTGGTTCTCCACT
CAGGTTGACACTGTGGCCACCAAGGTGAAGGATGCTCTGGAGTTTTGGCTGCAAGCTGGC
GTGGATGGGTTCCAGGTTCGGGACATAGAGAATCTGAAGGATGCATCCTCATTCTTGGCT
GAGTGGCAAAATATCACCAAGGGCTTCAGTGAAGACAGGCTCTTGATTGCGGGGACTAAC
TCCTCCGACCTTCAGCAGATCCTGAGCCTACTCGAATCCAACAAAGACTTGCTGTTGACT
AGCTCATACCTGTCTGATTCTGGTTCTACTGGGGAGCATACAAAATCCCTAGTCACACAG
TATTTGAATGCCACTGGCAATCGCTGGTGCAGCTGGAGTTTGTCTCAGGCAAGGCTCCTG
ACTTCCTTCTTGCCGGCTCAACTTCTCCGACTCTACCAGCTGATGCTCTTCACCCTGCCA
GGGACCCCTGTTTTCAGCTACGGGGATGAGATTGGCCTGGATGCAGCTGCCCTTCCTGGA
CAGCCTATGGAGGCTCCAGTCATGCTGTGGGATGAGTCCAGCTTCCCTGACATCCCAGGG
GCTGTAAGTGCCAACATGACTGTGAAGGGCCAGAGTGAAGACCCTGGCTCCCTCCTTTCC
TTGTTCCGGCGGCTGAGTGACCAGCGGAGTAAGGAGCGCTCCCTACTGCATGGGGACTTC
CACGCGTTCTCCGCTGGGCCTGGACTCTTCTCCTATATCCGCCACTGGGACCAGAATGAG
CGTTTTCTGGTAGTGCTTAACTTTGGGGATGTGGGCCTCTCGGCTGGACTGCAGGCCTCC
GACCTGCCTGCCAGCGCCAGCCTCCCAGCCAAGGCTGACCTCCTGCTCAGCACCCAGCCA
GGCCGTGAGGAGGGCTCCCCTCTTGAGCTGGAACGCCTGAAACTGGAGCCTCACGAAGGG
CTGCTGCTCCGCTTCCCCTACGCGGCCTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
J02939

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_6_Locus:
11q13

# Macromolecular_Interacting_Partner_6_SNPs:
rs4726; rs6932; rs489381; rs10897300; rs10897301; rs10792362; rs3809075; rs12221878; rs481235; rs12577251; rs4567465; rs12794763; rs7104190; rs507101; rs7106901; rs12098955; rs561385; rs519473; rs12804553; rs12274689; rs7935096; rs2070870; rs2920155; rs2282477; rs1140538; rs7944051; rs3015957; rs11548759; rs1051342; rs11548756; rs1051289; rs1051290; rs1802910; rs1051237; rs1802911; rs11548760; rs1051285; rs12272749; rs35228448; rs540791; rs549706; rs11231260; rs543622; rs541444; rs34047097; rs35246991; rs1815840; rs3840765; rs11231257; rs544453; rs35881347; rs35320203; rs2957168; rs7130029; rs519425; rs541388; rs34176851; rs535854; rs35091612; rs7106895; rs2096559; rs473815; rs11318751; rs5792273; rs12797676; rs499294; rs34225665; rs3809074; rs2957166; rs7115838; rs12803557; rs521939; rs1938675; rs563394; rs1300138; rs12225962; rs2105515; rs36034735; rs486306; rs12788771; rs1212628; rs1286159; rs5792274; rs12794229; rs7117639; rs495776; rs11231259; rs12366036; rs509327; rs35657900; rs11231261; rs496788; rs35988334; rs12788770; rs34335071; rs1298673; rs766316; rs34722625; rs560603; rs11824602; rs565303; rs34494671; rs35455481; rs7101685; rs1286160; rs510307; rs12270563; rs11231254; rs11231262; rs11318752; rs549635; rs12270604; rs2957167; rs11317361; rs7126772; rs34436839; rs11341257; rs577134; rs11558674; rs1059292; rs11231249; rs11231250; rs12270342; rs12295052; rs1785940; rs2071036; rs2269353; rs2507820; rs2509678; rs2510083; rs3737388; rs3737389; rs4034; rs480730; rs493851; rs498751; rs524891; rs547248; rs560006

# Macromolecular_Interacting_Partner_6_General_References:
3476959; 3036867; 3480538; 3265470; 12754519; 11840567; 12270127

# Macromolecular_Interacting_Partner_6_References:
Not Available

# Macromolecular_Interacting_Partner_7_ID:
8650

# Macromolecular_Interacting_Partner_7_Name:
Neutral amino acid transporter A

# Macromolecular_Interacting_Partner_7_Synonyms:
SATT; Solute carrier family 1 member 4; Alanine/serine/cysteine/ threonine transporter; ASCT1

# Macromolecular_Interacting_Partner_7_Gene_Name:
SLC1A4

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Neutral amino acid transporter 
AMEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLG
AALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVA
YFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLF
PSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKK
LGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIF
ASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEEN
NGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVG
AAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQ
KATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
532

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
55724

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.18

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
 Function:  transporter activity
Function:  organic acid transporter activity
Function:  carboxylic acid transporter activity
Function:  dicarboxylic acid transporter activity
Function:  sodium:dicarboxylate symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  organic acid transport
Process:  carboxylic acid transport
Process:  dicarboxylic acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_7_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_7_Specific_Function:
Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00375:SDF

# Macromolecular_Interacting_Partner_7_Signals:
1-104

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
42-62
88-108
119-139
217-237
257-277
298-318
328-348
373-393
418-438

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
348012

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
SATT_HUMAN (P43007)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
SLC1A4

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
SLC1A4

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:10942

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Membrane; multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1599 bp
ATGGAGAAGAGCAACGAGACCAACGGCTACCTTGACAGCGCTCAGGCGGGGCCTGCGGCC
GGGCCCGGAGCTCCGGGGACCGCGGCGGGACGCGCACGGCGTTGCGCGCGCTTCCTGCGG
CGCCAAGCGCTGGTGCTGCTCACCGTGTCCGGGGTGCTGGCGGGCGCGGGCCTGGGCGCG
GCGTTGCGCGGGCTCAGCCTGAGCCGCACGCAGGTCACCTACCTGGCCTTCCCCGGCGAG
ATGCTGCTCCGCATGCTGCGCATGATCATCCTGCCGCTGGTGGTCTGCAGCCTGGTGTCG
GGCGCCGCCTCGCTCGATGCCAGCTGCCTCGGGCGTCTGGGCGGCATCCGTGTCGCCTAC
TTTGGCCTCACCACACTGAGTGCCTCGGCGCTCGCCGTGGCCTTGGCGTTCATCATCAAG
CCAGGATCCGGTGCGCAGACCCTTCAGTCCAGCGACCTGGGGCTGGAGGACTCGGGGCCT
CCTCCTGTCCCCAAAGAGACGGTGGACTCTTTCCTCGACCTGGCCAGAAACCTGTTTCCC
TCCAATCTTGTGGTTGCAGCTTTCCGTACGTATGCAACCGATTATAAAGTCGTGACCCAG
AACAGCAGCTCTGGAAATGTAACCCATGAAAAGATCCCCATAGGCACTGAGATAGAAGGG
ATGAACATTTTAGGATTGGTCCTGTTTGCTCTGGTGTTAGGAGTGGCCTTAAAGAAACTA
GGCTCCGAAGGAGAAGACCTCATCCGTTTCTTCAATTCCCTCAACGAGGCGACGATGGTG
CTGGTGTCCTGGATTATGTGGTACGTACCTGTGGGCATCATGTTCCTTGTTGGAAGCAAG
ATCGTGGAAATGAAAGACATCATCGTGCTGGTGACCAGCCTGGGGAAATACATCTTCGCA
TCTATATTGGGCCATGTTATTCATGGAGGAATTGTTCTGCCACTTATTTATTTTGTTTTC
ACACGAAAAAACCCATTCAGATTCCTCCTGGGCCTCCTCGCCCCATTTGCGACAGCATTT
GCTACCTGCTCCAGCTCAGCGACCCTTCCCTCTATGATGAAGTGCATTGAAGAGAACAAT
GGTGTGGACAAGAGGATCAGCAGGTTTATTCTCCCCATCGGGGCCACCGTGAACATGGAC
GGAGCAGCCATCTTCCAGTGTGTGGCCGCGGTGTTCATTGCGCAACTCAACAACATAGAG
CTCAACGCAGGACAGATTTTCACCATTCTAGTGACTGCCACAGCGTCCAGTGTTGGAGCA
GCAGGCGTGCCAGCTGGAGGGGTCCTCACCATTGCCATTATCCTGGAGGCCATTGGGCTG
CCTACTCATGACCTGCCTCTGATCCTGGCTGTGGACTGGATTGTGGACCGGACCACCACG
GTGGTGAATGTGGAAGGGGATGCCCTGGGTGCAGGCATTCTCCACCACCTGAATCAGAAG
GCAACAAAGAAAGGCGAGCAGGAACTTGCTGAGGTGAAAGTGGAAGCCATCCCCAACTGC
AAGTCTGAGGAGGAGACATCGCCCCTGGTGACACACCAGAACCCCGCTGGCCCCGTGGCC
AGTGCCCCAGAACTGGAATCCAAGGAGTCGGTTCTGTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
L14595

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_7_Locus:
2p15-p13

# Macromolecular_Interacting_Partner_7_SNPs:
rs759458; rs7563131; rs7559202; rs7589132; rs7850; rs1058922; rs1058926; rs3796052; rs7563257; rs10197339; rs7574431; rs2075209; rs3732062; rs6546119; rs6728107; rs6546120; rs1060315; rs2422358; rs11891502; rs12617488; rs3770705; rs10194230; rs2268483; rs1541580; rs11891647; rs7570684; rs3819816; rs7588457; rs7583682; rs7586345; rs7559797; rs11904597; rs17029749; rs11886554; rs2268481; rs11687321; rs11890755; rs2300546; rs7580228; rs2007061; rs1861443; rs7601530; rs7601029; rs7574973; rs11689731; rs17029736; rs12615879; rs7601562; rs7601142; rs7566124; rs17029737; rs11900188; rs11675218; rs12615528; rs7605525; rs7605452; rs17029771; rs7425340; rs1064512; rs34259099; rs6756968; rs34416635; rs13398698; rs35024658; rs12620864; rs7609068; rs12620890; rs13416211; rs7608915; rs3839063; rs34497145; rs7563137; rs11283317; rs35937278; rs35342526; rs35002509; rs10173484; rs2160387; rs5831732; rs2300548; rs10190648; rs34956531; rs34093121; rs2422359; rs17624279; rs10659734; rs3216589; rs34617398; rs34461710; rs34352138; rs10176896; rs7569409; rs11343144; rs36110974; rs34954546; rs11277470; rs2300547; rs11352632; rs6706035; rs10659733; rs35815508; rs17029731; rs2268479; rs34557334; rs2268482; rs13032158; rs34790840; rs34330989; rs11343057; rs35311819; rs34807901; rs11352633; rs10572273; rs34203436; rs35022766; rs7585341; rs1056703; rs9808015; rs13010290; rs6712347; rs10182988; rs3770707; rs7559886; rs6750052; rs7592468; rs11449616; rs34467179; rs34598433; rs7592015; rs34799701; rs35470885; rs35894508; rs11888075; rs2268480; rs13392255; rs3770706; rs34821720; rs2268478; rs11292885; rs2110950; rs11274301; rs7569840; rs11542203; rs1008617; rs11390852; rs12998384; rs7604992; rs10170033; rs10193537; rs7608786; rs35490784; rs10209552; rs10211524; rs12464724; rs17669826; rs2422435; rs2540966; rs2540967; rs2540969; rs2540970; rs2723076; rs35528068; rs6546118; rs7574847; rs9677813

# Macromolecular_Interacting_Partner_7_General_References:
8101838; 8340364; 7896285

# Macromolecular_Interacting_Partner_7_References:
Not Available

# Macromolecular_Interacting_Partner_8_ID:
8673

# Macromolecular_Interacting_Partner_8_Name:
Sodium-coupled neutral amino acid transporter 4

# Macromolecular_Interacting_Partner_8_Synonyms:
Na(+-coupled neutral amino acid transporter 4; Amino acid transporter A3; System A amino acid transporter 3; System N amino acid transporter 3; Solute carrier family 38 member 4

# Macromolecular_Interacting_Partner_8_Gene_Name:
SLC38A4

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Sodiumcoupled neutral amino acid transporter 4
MDPMELRNVNIEPDDESSSGESAPDSYIGIGNSEKAAMSSQFANEDTESQKFLTNGFLGK
KKLADYADEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSL
YSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEV
IRAFMGLEENTGEWYLNGNYLIIFVSVGIILPLSLLKNLGYLGYTSGFSLTCMVFFVSVV
IYKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLPNNSESSDVNFMMDYTHRNPAGLDEN
QAKGSLHDSGVEYEAHSDDKCEPKYFVFNSRTAYAIPILVFAFVCHPEVLPIYSELKDRS
RRKMQTVSNISITGMLVMYLLAALFGYLTFYGEVEDELLHAYSKVYTLDIPLLMVRLAVL
VAVTLTVPIVLFPIRTSVITLLFPKRPFSWIRHFLIAAVLIALNNVLVILVPTIKYIFGF
IGASSATMLIFILPAVFYLKLVKKETFRSPQKVGALIFLVVGIFFMIGSMALIIIDWIYD
PPNSKHH

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
547

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
60765

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
6.45

# Macromolecular_Interacting_Partner_8_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_8_Specific_Function:
Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF01490:Aa_trans

# Macromolecular_Interacting_Partner_8_Signals:
1-531

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
81-101
105-125
152-172
196-216
221-241
333-353
370-390
412-432
454-474
477-497
515-535

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
13876616

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
S38A4_HUMAN (Q969I6)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
SLC38A4

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
SLC38A4

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:14679

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Cell membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1644 bp
ATGGATCCCATGGAACTGAGAAATGTCAACATCGAACCAGATGATGAGAGCAGCAGTGGA
GAAAGTGCTCCAGATAGCTACATCGGGATAGGAAATTCAGAAAAGGCAGCAATGAGCAGT
CAATTTGCTAATGAAGACACTGAAAGTCAGAAATTCCTGACAAATGGATTTTTGGGGAAA
AAGAAGCTGGCAGATTATGCTGATGAACACCATCCCGGAACCACTTCCTTTGGAATGTCT
TCATTTAACCTGAGTAATGCCATCATGGGCAGTGGGATCCTGGGCTTGTCCTATGCCATG
GCCAACACAGGGATCATACTTTTTATAATCATGCTGCTTGCTGTGGCAATATTATCACTG
TATTCAGTTCACCTTTTATTAAAAACAGCCAAGGAAGGAGGGTCTTTGATTTATGAAAAA
TTAGGAGAAAAGGCATTTGGATGGCCGGGAAAAATTGGAGCTTTTGTTTCCATTACAATG
CAGAACATTGGAGCAATGTCAAGCTACCTCTTTATCATTAAATATGAACTACCTGAAGTA
ATCAGAGCATTCATGGGACTTGAAGAAAATACTGGAGAATGGTACCTCAATGGCAACTAC
CTCATCATATTTGTGTCTGTTGGAATTATTCTTCCACTTTCGCTCCTTAAAAATTTAGGT
TATCTTGGCTATACCAGTGGATTTTCTCTTACCTGCATGGTGTTTTTTGTTAGTGTGGTG
ATTTACAAGAAATTCCAAATACCCTGCCCTCTACCTGTTTTGGATCACAGTGTTGGAAAT
CTGTCATTCAACAACACGCTTCCAATGCATGTGGTAATGTTACCCAACAACTCTGAGAGT
TCTGATGTGAACTTCATGATGGATTACACCCACCGCAATCCTGCAGGGCTGGATGAGAAC
CAGGCCAAGGGCTCTCTTCATGACAGTGGAGTAGAATATGAAGCTCATAGTGATGACAAG
TGTGAACCCAAATACTTTGTATTCAACTCCCGGACGGCCTATGCAATTCCTATCCTAGTA
TTTGCTTTTGTATGCCACCCTGAGGTCCTTCCCATCTACAGTGAACTTAAAGATCGGTCC
CGGAGAAAAATGCAAACGGTGTCAAATATTTCCATCACGGGGATGCTTGTCATGTACCTG
CTTGCCGCCCTCTTTGGTTACCTAACCTTCTATGGAGAAGTTGAAGATGAATTACTTCAT
GCCTACAGCAAAGTGTATACATTAGACATCCCTCTTCTCATGGTTCGCCTGGCAGTCCTT
GTGGCAGTAACACTAACTGTGCCCATTGTCCTCTTCCCAATTCGTACATCAGTGATCACA
CTGTTATTTCCCAAACGACCCTTCAGCTGGATACGACATTTCCTGATTGCAGCTGTGCTT
ATTGCACTTAATAATGTTCTGGTCATCCTTGTGCCAACTATAAAATACATCTTCGGATTC
ATAGGGGCTTCTTCTGCCACTATGCTGATTTTTATTCTTCCAGCAGTTTTTTATCTTAAA
CTTGTCAAGAAAGAAACTTTTAGGTCACCCCAAAAGGTCGGGGCTTTAATTTTCCTTGTG
GTTGGAATATTCTTCATGATTGGAAGCATGGCACTCATTATAATTGACTGGATTTATGAT
CCTCCAAATTCCAAGCATCACTAA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
AF305814

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_8_Locus:
12q13

# Macromolecular_Interacting_Partner_8_SNPs:
rs2429467; rs11183610; rs180414; rs2465604; rs2429472; rs2250010; rs2191162; rs2715788; rs2465608; rs2430921; rs4627160; rs11183605; rs180438; rs2897981; rs10881001; rs2079787; rs7974413; rs11183618; rs2429470; rs4482114; rs11183617; rs7963399; rs11183616; rs7967842; rs4587804; rs7132006; rs10161209; rs2109125; rs11183619; rs2465605; rs3862137; rs4569081; rs11183620; rs12321267; rs12582305; rs12424453; rs7968752; rs7954772; rs2429473; rs7963807; rs2465586; rs17097332; rs4447249; rs7138295; rs7959916; rs7953215; rs7973308; rs12304394; rs4491335; rs180437; rs12301396; rs10748455; rs2429471; rs12300935; rs4554975; rs12318696; rs10437941; rs7963364; rs10881002; rs7971412; rs7974393; rs12227634; rs17666239; rs12301345; rs11183621; rs17097341; rs10881003; rs180430; rs180431; rs2715779; rs2465585; rs180416; rs2465584; rs180421; rs1860372; rs180408; rs180433; rs180410; rs180409; rs180420; rs180417; rs7297226; rs4768758; rs2287471; rs180427; rs180419; rs2429474; rs4768759; rs2430922; rs2465583; rs6582676; rs180407; rs11183608; rs2465582; rs180434; rs180405; rs11183609; rs180426; rs180435; rs180412; rs2465644; rs12307687; rs180424; rs180429; rs180415; rs17097246; rs2075335; rs12305532; rs180428; rs12316767; rs2287472; rs12581848; rs12307218; rs4768757; rs180425; rs12317419; rs12306007; rs3794308; rs12301214; rs2302855; rs180423; rs180403; rs17097220; rs12313427; rs17602430; rs1860371; rs12826359; rs180422; rs2429465; rs2287473; rs17097286; rs11609184; rs2429466; rs180436; rs180404; rs1468970; rs1468972; rs1468971; rs2465614; rs4340151; rs2430920; rs2465613; rs12315893; rs7489259; rs7976413; rs7962993; rs7965688; rs7976286; rs4262792; rs12309262; rs35448881; rs5797999; rs12426237; rs34557682; rs10523982; rs12824626; rs2543339; rs4537845; rs34666594; rs2429469; rs10161451; rs34886536; rs5798000; rs4575359; rs11558891; rs9804926; rs10693721; rs4388977; rs2430923; rs2429468; rs34878223; rs3764027; rs2465606; rs2465588; rs35064296; rs17097355; rs34251832; rs12308177; rs1072246; rs2465587; rs4335624; rs5798001; rs2907513; rs12819255; rs4768756; rs2532606; rs11370884; rs34540549; rs12298652; rs34594658; rs4623983; rs35779004; rs35709312; rs2429464; rs10691485; rs12832145; rs35826321; rs180413; rs2216433; rs35066357; rs12319423; rs2465616; rs10691484; rs11610757; rs11315253; rs34637197; rs17097192; rs35050099; rs7313706; rs549755; rs36053062; rs11335369; rs3217194; rs11183614; rs12318924; rs4631970; rs34909119; rs12316757; rs180411; rs180432; rs10673975; rs34246069; rs35085914; rs180406; rs34654635; rs34189139; rs11335992; rs4439596; rs416435; rs35774013; rs5797998; rs3958775; rs35668113; rs446993; rs180418; rs34764764; rs34209899; rs11338774; rs10785645; rs11183625; rs11609070; rs11615573; rs12307895; rs12311057; rs12317975; rs12318756; rs12318994; rs12812119; rs17097368; rs17684703; rs2193649; rs2216432; rs2408623; rs2430917; rs2430919; rs2465595; rs2715775; rs2715783; rs4374015; rs4495962; rs4497488; rs4511364; rs4533116; rs4994910; rs7953233; rs7955552; rs7964210; rs7978689; rs7978822; rs7978926

# Macromolecular_Interacting_Partner_8_General_References:
11342143; 11414754

# Macromolecular_Interacting_Partner_8_References:
Not Available

# Macromolecular_Interacting_Partner_9_ID:
8881

# Macromolecular_Interacting_Partner_9_Name:
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

# Macromolecular_Interacting_Partner_9_Synonyms:
Amino acid transporter ATB0+; Solute carrier family 6 member 14

# Macromolecular_Interacting_Partner_9_Gene_Name:
SLC6A14

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Sodium and chloridedependent neutral and basic amino acid transporter B0+
MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVW
RFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGIT
MVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNK
GIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLA
LCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQ
SNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVF
AGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLG
LDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHF
CAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAI
FIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCC
RPASNWGPYLEQHRGERYKDMVDPKKEADHEIPTVSGSRKPE

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
642

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
72154

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
8.27

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
 Function:  transporter activity
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_9_Signals:
1-469

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
45-65
72-92
110-130
235-255
261-281
315-335
348-368
399-419
450-477
480-500
528-548
563-583

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
5732680

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
S6A14_HUMAN (Q9UN76)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
SLC6A14

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
SLC6A14

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:11047

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>1929 bp
ATGGACAAGTTGAAATGCCCGAGTTTCTTCAAGTGCAGGGAGAAGGAGAAAGTGTCGGCT
TCATCAGAGAATTTCCATGTTGGTGAAAATGATGAGAATCAGGACCGTGGTAACTGGTCC
AAAAAATCGGATTATCTTCTATCTATGATTGGATACGCAGTGGGATTAGGAAATGTGTGG
AGATTTCCATATCTGACCTACAGCAATGGTGGAGGCGCCTTCTTGATACCTTATGCAATT
ATGTTAGCATTGGCTGGTTTACCTTTGTTCTTTCTGGAGTGTTCACTGGGACAATTTGCT
AGCTTAGGTCCAGTTTCAGTTTGGAGGATTCTTCCATTGTTTCAAGGTGTGGGAATTACA
ATGGTCCTGATCTCCATTTTTGTGACAATCTATTACAATGTCATAATTGCCTATAGTCTT
TACTACATGTTTGCTTCTTTTCAAAGTGAACTACCATGGAAAAATTGTTCTTCGTGGTCA
GATAAAAACTGTAGCAGATCACCAATAGTAACTCACTGTAATGTGAGTACAGTGAATAAA
GGAATACAAGAGATCATCCAAATGAATAAAAGCTGGGTAGACATCAACAATTTTACCTGC
ATCAACGGCAGTGAAATTTATCAGCCAGGGCAGCTTCCCAGTGAACAATATTGGAATAAA
GTGGCGCTCCAACGGTCAAGTGGAATGAATGAGACTGGAGTAATTGTTTGGTATTTAGCA
CTTTGTCTTCTTCTGGCTTGGCTCATAGTTGGAGCAGCACTATTTAAAGGAATCAAATCG
TCTGGCAAGGTGGTATATTTTACAGCTCTTTTCCCCTATGTGGTCCTACTCATCCTGTTA
GTACGAGGTGCAACTCTGGAGGGTGCTTCAAAAGGCATTTCATACTATATTGGAGCCCAG
TCAAATTTTACAAAACTTAAGGAAGCTGAGGTATGGAAAGATGCTGCCACTCAGATATTT
TACTCCCTTTCAGTGGCTTGGGGTGGCTTAGTTGCTCTATCATCTTACAATAAGTTCAAA
AACAACTGCTTCTCTGATGCCATTGTGGTTTGTTTGACAAACTGTCTCACTAGCGTGTTT
GCTGGATTTGCTATTTTTTCTATATTGGGACACATGGCCCATATATCTGGAAAGGAAGTT
TCTCAAGTTGTAAAATCAGGTTTTGATTTGGCATTCATTGCCTATCCAGAGGCTCTAGCC
CAACTCCCAGGTGGTCCATTTTGGTCCATATTATTTTTTTTCATGCTTTTAACTTTGGGT
CTCGATTCTCAGTTTGCTTCGATTGAAACGATCACAACAACAATTCAAGATTTATTTCCC
AAAGTGATGAAGAAAATGAGGGTTCCCATAACTTTGGGCTGCTGCTTGGTTTTGTTTCTC
CTTGGTCTCGTCTGTGTGACTCAGGCTGGAATTTACTGGGTTCATCTGATTGACCACTTC
TGTGCTGGATGGGGCATTTTAATTGCAGCTATACTGGAGCTAGTTGGAATCATCTGGATT
TATGGAGGGAACAGATTCATTGAGGATACAGAAATGATGATTGGAGCAAAGAGGTGGATA
TTCTGGCTATGGTGGAGAGCTTGCTGGTTTGTAATTACGCCTATCCTTTTGATTGCAATA
TTTATCTGGTCATTGGTGCAATTTCATAGACCTAATTATGGCGCAATTCCATACCCTGAC
TGGGGAGTTGCTTTAGGCTGGTGTATGATTGTTTTCTGCATTATTTGGATACCAATTATG
GCTATCATAAAAATAATTCAGGCTAAAGGAAACATCTTTCAACGCCTTATAAGTTGCTGC
AGACCAGCTTCTAACTGGGGTCCATACCTGGAACAACATCGTGGGGAAAGATATAAAGAC
ATGGTAGATCCTAAAAAAGAGGCTGACCATGAAATACCTACTGTTAGTGGCAGCAGAAAA
CCGGAATGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
AF151978

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_9_Locus:
Xq23-q24

# Macromolecular_Interacting_Partner_9_SNPs:
rs12720074; rs2011162; rs5905179; rs12710570; rs5905289; rs2011198; rs2312055; rs2032525; rs5905176; rs5905284; rs7059155; rs2071877; rs4824325; rs10217924; rs5905178; rs6608646; rs12392462; rs2312057; rs12391221; rs17242824; rs5905288; rs12559530; rs10218102; rs10521579; rs12710569; rs10521578; rs5905285; rs5952101; rs12720080; rs12720088; rs5952099; rs12720083; rs5905177; rs4824358; rs4824324; rs12720076; rs4824359; rs12720084; rs12720079; rs5952103; rs2312056; rs12720089; rs17095419; rs12393509; rs4824323; rs2312054; rs7052454; rs12710568; rs12720073; rs12834312; rs3788766; rs5905283; rs12720085; rs28523889; rs6608648; rs11350870; rs34685017; rs28699570; rs12720092; rs28628632; rs12720078; rs5952174; rs35604008; rs5952104; rs5905287; rs6608645; rs12388847; rs10629819; rs12720087; rs12720091; rs35269408; rs17308739; rs3043424; rs35542990; rs5952100; rs5952102; rs35201069; rs6651554; rs12720077; rs10218234; rs6608647; rs12858125; rs34117081; rs5952175; rs12720082; rs34490652; rs4068397; rs7066547; rs7054956; rs12832551; rs10218418; rs12720075; rs12720086; rs12720090; rs35315031; rs7062559; rs10218017; rs12390279; rs12833869; rs12835480; rs12839137; rs12844003; rs17308697; rs2103697; rs2301451; rs5952181; rs6520234; rs6608511; rs6608514; rs6608644; rs6608650

# Macromolecular_Interacting_Partner_9_General_References:
10446133

# Macromolecular_Interacting_Partner_9_References:
Not Available

End of HMDB00187

Beginning of HMDB00189
# Accession_No:
HMDB00189

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-07-06 11:57:07

# biospider_lastupdate:
2007-07-25 10:29:23

# Common_Name:
Inosine triphosphate

# Description:
Inosine triphosphate is an intermediate in the Purine metabolism pathway. Relatively high levels of inosine triphosphate (ITP) in red cells are found in individuals as result of deficiency of inosine triphosphatase (EC 3.1.3.56, a cytosolic nucleoside triphosphate pyrophosphohydrolase specific for ITP). (PMID : 170291)
ITPase deficiency is not associated with any defined pathology other than the characteristic and abnormal accumulation of ITP in red blood cells. Nevertheless, ITPase deficiency may have pharmacogenomic implications, and the abnormal metabolism of 6-mercaptopurine in ITPase-deficient patients may lead to thiopurine drug toxicity. (PMID 1204209)

# Synonyms:
inosine 5'-(tetrahydrogen triphosphate); Inosine 5-triphopshate; Inosine tripolyphosphate; 2'-inosine-5'-triphosphate; Inosine 5(tetrahydrogen triphosphate); ITT; 5'-ITP; 5-ITP; ITP; Inosine 5; Inosine 5'-triphosphate; Inosine triphosphate; Inosine triphosphic acid 

# Chemical_IUPAC_Name:
[[[3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid

# Chemical_Formula:
C10H15N4O14P3

# Chemical_Structure:
tbl_chemical:::HMDB00189_ZOOM.png:::119283241256177328

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00189_THUMB.png:::119283241031296466

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines; Nucleoside Triphosphates

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; secondary alcohol; 1,2-diol; oxo(het)arene; phosphoric acid ester; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
507.97974

# Molecular_Weight_Avg:
508.16577

# Smiles_String_isomeric:
O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)N2C=NC3=C2N=CN=C3O

# Smiles_String_canonical:
OC1C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)OC(C1O)N2C=NC3=C2N=CN=C3O

# KEGG_Compound_ID:
C00081

# BioCyc_ID:
DITP

# PubChem_CID:
8583

# PubChem_SID:
841581; 14933601; 16004979; 8145033; 24874918; 14720267; 151739; 7979614; 3381

# OMIM_ID:
147520

# Metagene_ID:
Not Available

# BiGG_ID:
33780

# Wikipedia_ID:
ITP

# METLIN_ID:
5204

# Ref_ID:
11278832; 6120123; 11336985; 11762611; 990987; 15708; 12384777; 9337071; 4842021; 10625215; 6147059; 1204209

# ChEBI_ID:
16039

# CAS_Registry_Number:
132-06-9

# InChI:
InChI=1/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

# Synthesis_Reference:
Kleinzeller, A., Biochem. J., 1942, 36, 729

# Melting_Point:
Not Available

# Melting_Point_predicted:
191.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
903.5 mg/mL [sodium salt, HMP experimental]

# H2O_Solubility_Predicted:
4.78 mg/mL [Predicted by ALOGPS]

# phys_charge:
-4

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-0.67 [Predicted by ALOGPS]; -5.5 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Inosine 5'-triphosphate.pdf:::1132562213668621216

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Inosine_triphosphate.mol:::1132723812796183453

# SDF_File_[Text]:
tbl_chemical:::HMDB00189.sdf:::119283240558891906

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00189.pdb:::119283240877494835

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::050104_P00_08_IS_1DP_presat.png:::115263521525373180

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::050104_P00_08_IS_1DP_presat_1.zip:::114721079281634622

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::050104_P00_08_IS_1DP_Assigned.png:::115705318584148633

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050104_P00_08_IS_2DHSQC_784.png:::114805793579297111

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050104_P00_08_IS_2DHSQC_784.zip:::114805793580381931

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050104_P00_08_IS_2DHSQC_784_Assigned.png:::116284757363683796

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Inosine triphosphate.gif:::1132732120046840247

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00189_peaks.txt:::1156309605293356400

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Inosine triphosphate_C.gif:::1132737716622551077

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00189_peaks.txt:::1156310794617184309

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000255.png:::11690744527345890

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000255.txt:::116907445273411263

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000255.png:::116890833214020420

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000255.txt:::116890833239026528

# Cellular_Location:
Cytoplasm; mitochondria; nucleus

# Tissue_Location:
Erythrocyte

# deuterated:
No

# Biofluid_Location:
Blood

# Concentration_[Normal]:
Not Available


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Inosine Triphosphate Pyrophosphohydrolase (ITPase) Deficiency

# Pathway_Names:
Propanoate metabolism;Pyruvate metabolism;Glycolysis;Fructose and mannose metabolism;Galactose metabolism;Starch and sucrose metabolism;Streptomycin biosynthesis;Aminosugars metabolism;Purine metabolism

# Pathway_Images:
;;Glycolysis.jpg;fructose_metabolism.jpg;;;;;Purine_Synthesis.jpg

# KEGG_Images:
map00640;map00620;map00010;map00051;map00052;map00500;map00521;map00530;map00230

# Pathway_Graphs:
;;Glycolysis_Graph.jpg;fructose_metabolism_Graph.jpg;;;;;Purine_Synthesis_Graph.jpg

# Pathway_SBMLs:
;;Glycolysis.xml;fructose_metabolism.xml;;;;;Purine_Synthesis.xml

# Metabolic_Enzyme_1_ID:
6171

# Metabolic_Enzyme_1_Name:
Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
Succinyl-CoA synthetase subunit alpha; SCS- alpha

# Metabolic_Enzyme_1_Gene_Name:
SUCLG1

# Metabolic_Enzyme_1_Protein_Sequence:
>SuccinylCoA ligase GDPforming subunit alpha, mitochondrial precursor
MVSGSSGLAAARLLSRSFLLPQNGIRHCSYTASRQHLYVDKNTKIICQGFTGKQGTFHSQ
QALEYGTKLVGGTTPGKGGQTHLGLPVFNTVKEAKEQTGATASVIYVPPPFAAAAINEAI
EAEIPLVVCITEGIPQQDMVRVKHKLLRQEKTRLIGPNCPGVINPGECKIGIMPGHIHKK
GRIGIVSRSGTLTYEAVHQTTQVGLGQSLCVGIGGDPFNGTDFIDCLEIFLNDSATEGII
LIGEIGGNAEENAAEFLKQHNSGPNSKPVVSFIAGLTAPPGRRMGHAGAIIAGGKGGAKE
KISALQSAGVVVSMSPAQLGTTIYKEFEKRKML

# Metabolic_Enzyme_1_Number_of_Residues:
333

# Metabolic_Enzyme_1_Molecular_Weight:
35048

# Metabolic_Enzyme_1_Theoretical_pI:
9.24

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
GTP + succinate + CoA = GDP + phosphate + succinyl-CoA

# Metabolic_Enzyme_1_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00640  Propanoate metabolism

# Metabolic_Enzyme_1_Reaction:
GTP + succinate + CoA = GDP + phosphate + succinyl-CoA

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF02629:CoA_binding;
PF00549:Ligase_CoA

# Metabolic_Enzyme_1_Signals:
1-19

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 6.2.1.4

# Metabolic_Enzyme_1_GenBank_ID_Protein:
9409794

# Metabolic_Enzyme_1_SwissProt_ID:
SUCA_HUMAN (P53597)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
SUCLG1

# Metabolic_Enzyme_1_Geneatlas_id:
SUCLG1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:11449

# Metabolic_Enzyme_1_PDB_ID:
1EUC

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_1_Gene_Sequence:
>1002 bp
ATGGTCTCCGGCAGCAGCGGCCTCGCCGCCGCCCGTCTCCTGTCGCGCAGCTTCCTCCTG
CCGCAGAATGGAATTCGGCATTGTTCCTACACAGCTTCTCGGCAACATCTCTATGTTGAT
AAAAATACAAAGATTATTTGCCAGGGTTTCACTGGCAAACAGGGCACCTTTCACAGCCAG
CAGGCATTGGAATATGGCACCAAACTCGTTGGAGGAACACTCCCAGGGAAAGGAGGCCAG
ACACATCTGGGCTTACCTGTCTTTAATACTGTGAAGGAGGCCAAAGAACAGACAGGAGCA
ACGGCTTCTGTCATTTATGTTCCTCCGCCTTTTGCTGCTGCTGCCATTAATGAAGCTATT
GAGGCAGAAATTCCCTTGGTTGTGTGTATCACTGAAGGAATTCCCCAGCAGGACATGGTA
CGAGTCAAGCACAAACTGCTGCGCCAGGAAAAGACAAGGCTAATTGGGCCCAACTGCCCT
GGAGTCATCAATCCTGGAGAATGTAAAATTGGGATCATGCCTGGCCATATTCACAAAAAA
GGAAGGATTGGCATTGTGTCCAGATCTGGCACCCTGACTTATGAAGCAGTTCACCAAACA
ACGCAAGTTGGATTGGGGCAGTCTTTGTGCGTTGGCATTGGAGGTGATCCTTTTAATGGA
ACAGATTTTATTGACTGCCTCGAAATCTTTTTGAACGATTCTGCCACAGAAGGCATCATA
TTGATTGGTGAAATTGGTGGTAATGCAGAAGAGAATGCTGCAGAATTTTTGAAGCAACAT
AATTCAGGTCCAAATTCCAAGCCTGTAGTGTCCTTCATTGCTGGTTTAACTGCTCCTCCT
GGGAGAAGAATGGGTCATGCCGGGGCAATTATTGCTGGAGGAAAAGGTGGAGCTAAAGAG
AAGATCTCTGCCCTTCAGAGTGCAGGAGTTGTGGTCAGTATGTCTCCTGCACAGCTGGGA
ACCACGATCTACAAGGAATTTGAAAAGAGGAAGATGCTATGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF104921

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_1_Locus:
2p11.2

# Metabolic_Enzyme_1_SNPs:
rs2832; rs957786; rs2014304; rs4831969; rs10210248; rs1159790; rs6739363; rs6547560; rs4831970; rs1964529; rs4832080; rs12714128; rs17025020; rs6735362; rs17757829; rs13411973; rs2364905; rs1037857; rs6721249; rs7607535; rs1599306; rs2364906; rs4831973; rs4832077; rs12618520; rs715788; rs4146945; rs17025067; rs6719880; rs3100688; rs17025063; rs4831972; rs11126964; rs17025048; rs17025051; rs4832079; rs4831971; rs17025075; rs6721136; rs17025013; rs3752782; rs6725858; rs17025055; rs1902161; rs17025065; rs17025070; rs10202632; rs12104696; rs17025058; rs10204310; rs7559546; rs6721056; rs2886213; rs13422954; rs6712363; rs17025046; rs11126963; rs6731664; rs12621740; rs3795867; rs7561462; rs3795866; rs6742132; rs6752272; rs6755519; rs1460712; rs12612707; rs35594530; rs11555948; rs3211087; rs35996428; rs3113911; rs6756343; rs11555949; rs35033593; rs35019088; rs10191009; rs4831974; rs1840409; rs11454892; rs11324101; rs5832611; rs10186999; rs13010189; rs11363262; rs35544237; rs13010203; rs10581685; rs5832609; rs35830105; rs11336864; rs3113909; rs36015835; rs3100689; rs33916383; rs13010383; rs34637575; rs5832610; rs35524076; rs10645272; rs7571828; rs33965088; rs28555285; rs6735361; rs35100622; rs1840410; rs34028894; rs3113910; rs35159610; rs34960098; rs34079796; rs28615728; rs7561831; rs11324102; rs34336705; rs13418895; rs5832612; rs35519949; rs13010208; rs11412343; rs1840408; rs13010390; rs34359115; rs35957108; rs10190527; rs3113908; rs28493187; rs35387036; rs11324100; rs2364903; rs11310460; rs3100687; rs13394181; rs35545078; rs33917339; rs36037213; rs12472997; rs34247162; rs11404434; rs11510400; rs12618709; rs12618867; rs12618941; rs13383257; rs1460706; rs1460707; rs1460708; rs17025038; rs17757342; rs1841419; rs2045675; rs3919794; rs4831968; rs4831975; rs6547559; rs6721949; rs6729777; rs6744676; rs6753640; rs7560763; rs756080; rs7575751; rs7589648

# Metabolic_Enzyme_1_General_References:
9128182

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6172

# Metabolic_Enzyme_2_Name:
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial precursor

# Metabolic_Enzyme_2_Synonyms:
Phosphoenolpyruvate carboxylase; PEPCK-M

# Metabolic_Enzyme_2_Gene_Name:
PCK2

# Metabolic_Enzyme_2_Protein_Sequence:
>Phosphoenolpyruvate carboxykinase GTP, mitochondrial precursor
MAALYRPGLRLNWHGLSPLGWPSCRSIQTLRVLSGDLGQLPTGIRDFVEHSARLCQPEGI
HICDGTEAENTATLTLLEQQGLIRKLPKYNNCWLARTDPKDVARVESKTVIVTPSQRDTV
PLPPGGARGQLGNWMSPADFQRAVDERFPGCMQGRTMYVLPFSMGPVGSPLSRIGVQLTD
SAYVVASMRIMTRLGTPVLQALGDGDFVKCLHSVGQPLTGQGEPVSQWPCNPEKTLIGHV
PDQREIISFGSGYGGNSLLGKKCFALRIASRLARDEGWLAEHMLILGITSPAGKKALCAA
AFPSACGKTNLAMMRPALPGWKVECVGDDIAWMRFDSEGRLRAINPENGFFGVAPGTSAT
TNPNAMATIQSNTIFTNVAETSDGGVYWEGIDQPLPPGVTVTSWLGKPWKPGDKEPCAHP
NSRFCAPARQCPIMDPAWEAPEGVPIDAIIFGGRRPKGVPLVYEAFNWRHGVFVGRAMRS
ESTAAAEHKGKIIMHDPFAMRPFFGYNFGHYLEHWLSMEGRKGAQLPRIFHVNWFRRDEA
GHFLWPGFGENARVLDWICRRLEGEDSARETPIGLVPKEGALDLSGLRAIDTTQLFSLPK
DFWEQEVRDIRSYLTEQVNQDLPKEVLAELEALERRVHKM

# Metabolic_Enzyme_2_Number_of_Residues:
640

# Metabolic_Enzyme_2_Molecular_Weight:
70638

# Metabolic_Enzyme_2_Theoretical_pI:
7.65

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  guanyl nucleotide binding
Function:  GTP binding
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
Function:  phosphoenolpyruvate carboxykinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  gluconeogenesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO(2)

# Metabolic_Enzyme_2_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00620  Pyruvate metabolism

# Metabolic_Enzyme_2_Reaction:
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00821:PEPCK

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 4.1.1.32

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1403050

# Metabolic_Enzyme_2_SwissProt_ID:
PPCKM_HUMAN (Q16822)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
PCK2

# Metabolic_Enzyme_2_Geneatlas_id:
PCK2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:8725

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_2_Gene_Sequence:
>1923 bp
ATGGCCGCATTGTACCGCCCTGGCCTGCGGCTTAACTGGCATGGGCTGAGCCCCTTGGGC
TGGCCATCATGCCGTAGCATCCAGACCCTGCGAGTGCTTAGTGGAGATCTGGGCCAGCTT
CCCACTGGCATTCGAGATTTTGTAGAGCACAGTGCCCGCCTGTGCCAACCAGAGGGCATC
CACATCTGTGATGGAACTGAGGCTGAGAATACTGCCACACTGACCCTGCTGGAGCAGCAG
GGCCTCATCCGAAAGCTCCCCAAGTACAATAACTGCTGGCTGGCCCGCACAGACCCCAAG
GATGTGGCACGAGTAGAGAGCAAGACGGTGATTGTAACTCCTTCTCAGCGGGACACGGTA
CCACTCCCGCCTGGTGGGGCCTGTGGGCAGCTGGGCAACTGGATGTCCCCAGCTGATTTC
CAGCGAGCTGTGGATGAGAGGTTTCCAGGCTGCATGCAGGGCCGCACCATGTATGTGCTT
CCATTCAGCATGGGTCCTGTGGGCTCCCCGCTGTCCCGCATCGGGGTGCAGCTCACTGAC
TCAGCCTATGTGGTGGCAAGCATGCGTATTATGACCCGACTGGGGACACCTGTGCTTCAG
GCCCTGGGAGATGGTGACTTTGTCAAGTGTCTGCACTCCGTGGGCCAGCCCCTGACAGGA
CAAGGGGAGCCAGTGAGCCAGTGGCCGTGCAACCCAGAGAAAACCCTGATTGGCCACGTG
CCCGACCAGCGGGAGATCATCTCCTTCGGCAGCGGCTATGGTGGCAACTCCCTGCTGGGC
AAGAAGTGCTTTGCCCTACGCATCGCCTCTCGGCTGGCCCGGGATGAGGGCTGGCTGGCA
GAGCACATGCTGATCCTGGGCATCACCAGCCCTGCAGGGAAGAAGGCGCTATGTGCAGCC
GCCTTCCCTAGTGCCTGTGGCAAGACCAACCTGGCTATGATGCGGCCTGCACTGCCAGGC
TGGAAAGTGGAGTGTGTGGGGGATGATATTGCTTGGATGAGGTTTGACAGTGAAGGTCGA
CTCCGGGCCATCAACCCTGAGAACGGCTTCTTTGGGGTTGCCCCTGGTACCTCTGCCACC
ACCAATCCCAACGCCATGGCTACAATCCAGAGTAACACTATTTTTACCAATGTGGCTGAG
ACCAGTGATGGTGGCGTGTACTGGGAGGGCATTGACCAGCCTCTTCCACCTGGTGTTACT
GTGACCTCCTGGCTGGGCAAACCCTGGAAACCTGGTGACAAGGAGCCCTGTGCACATCCC
AACTCTCGATTTTGTGCCCCGGCTCGCCAGTGCCCCATCATGGACCCAGCCTGGGAGGCC
CCAGAGGGTGTCCCCATTGACGCCATCATCTTTGGTGGCCGCAGACCCAAAGGGGTACCC
CTGGTATACGAGGCCTTCAACTGGCGTCATGGGGTGTTTGTGGGCAGAGCCATGCGCTCT
GAGTCCACTGCTGCAGCAGAACACAAAGGGAAGATCATCATGCACGACCCATTTGCCATG
CGGCCCTTTTTTGGCTACAACTTCGGGCACTACCTGGAACACTGGCTGAGCATGGAAGGG
CGCAAGGGGGCCCAGCTGCCCCGTATCTTCCATGTCAACTGGTTCCGGCGTGACGAGGCA
GGGCACTTCCTGTGGCCAGGCTTTGGGGAGAATGCTCGGGTGCTAGACTGGATCTGCCGG
CGGTTAGAGGGGGAGGACAGTGCCCGAGAGACACCCATTGGGCTGGTGCCAAAGGAAGGA
GCCTTGGATCTCAGCGGCCTCAGAGCTATAGACACCACTCAGCTGTTCTCCCTCCCCAAG
GACTTCTGGGAACAGGAGGTTCGTGACATTCGGAGCTACCTGACAGAGCAGGTCAACCAG
GATCTGCCCAAAGAGGTGTTGGCTGAGCTTGAGGCCCTGGAGAGACGTGTGCACAAAATG
TGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X92720

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_2_Locus:
14q12

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
8645161; 9657976

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5444

# Metabolic_Enzyme_3_Name:
Hexokinase-3

# Metabolic_Enzyme_3_Synonyms:
Hexokinase type III; HK III

# Metabolic_Enzyme_3_Gene_Name:
HK3

# Metabolic_Enzyme_3_Protein_Sequence:
>Hexokinase3
MDSIGSSGLRQGEETLSCSEEGLPGPSDSSELVQECLQQFKVTRAQLQQIQASLLGSMEQ
ALRGQASPAPAVRMLPTYVGSTPHGTEQGDFVVLELGATGASLRVLWVTLTGIEGHRVEP
RSQEFVIPQEVMLGAGQQLFDFAAHCLSEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRST
LISWTKGFRCSGVEGQDVVQLLRDAIRRQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVG
LVVDTGTNACYMEEARHVAVLDEDRGRVCVSVEWGSLSDDGALGPVLTTFDHTLDHESLN
PGAQRFEKMIGGLYLGELVRLVLAHLARCGVLFGGCTSPALLSQGSILLEHVAEMEDPST
GAARVHAILQDLGLSPGASDVELVQHVCAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQ
VAVATGGRVCERHPRFCSVLQGTVMLLAPECDVSLIPSVDGGGRGVAMVTAVAARLAAHR
RLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASSLRMLPTFVRATPDGSERGDFLA
LDLGGTNFRVLLVRVTTGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQ
SLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAI
VNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGD
DGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQ
RLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLC
GAGVAAVVEKIRGNRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSE
DGSGKGAALVTAVACRLAQLTRV

# Metabolic_Enzyme_3_Number_of_Residues:
923

# Metabolic_Enzyme_3_Molecular_Weight:
98921

# Metabolic_Enzyme_3_Theoretical_pI:
5.11

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_3_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism;
 map00521  Streptomycin biosynthesis;
 map00530  Aminosugars metabolism

# Metabolic_Enzyme_3_Reaction:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00349:Hexokinase_1;
PF03727:Hexokinase_2

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.7.1.1

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1255788

# Metabolic_Enzyme_3_SwissProt_ID:
HXK3_HUMAN (P52790)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
HK3

# Metabolic_Enzyme_3_Geneatlas_id:
HK3

# Metabolic_Enzyme_3_hgnc_id:
HGNC:4925

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>2772 bp
ATGGACTCCATTGGGTCTTCAGGGTTGCGGCAGGGGGAAGAAACCCTGAGTTGCTCTGAG
GAGGGCTTGCCCGGGCCCTCAGACAGCTCAGAGCTGGTGCAGGAGTGCCTGCAGCAGTTC
AAGGTGACAAGGGCACAGCTACAGCAGATCCAAGCCAGCCTCTTGGGTTCCATGGAGCAG
GCGCTGAGGGGACAGGCCAGCCCTGCCCCTGCGGTCCGGATGCTGCCTACATACGTGGGG
TCCACCCCACATGGCACTGAGCAAGGAGACTTCGTGGTGCTGGAGCTGGGGGCCACAGGG
GCCTCACTGCGTGTTTTGTGGGTGACTCTAACTGGCATTGAGGGGCATAGGGTGGAGCCC
AGAAGCCAGGAGTTTGTGATCCCCCAAGAGGTGATGCTGGGTGCTGGCCAGCAGCTCTTT
GACTTTGCTGCCCACTGCCTGTCTGAGTTCCTGGATGCGCAGCCTGTGAACAAACAGGGT
CTGCAGCTTGGCTTCAGCTTCTCTTTCCCTTGTCACCAGACGGGCTTGGACAGGAGCACC
CTCATTTCCTGGACCAAAGGTTTTAGGTGCAGTGGTGTGGAAGGCCAGGATGTGGTCCAG
CTGCTGAGAGATGCCATTCGGAGGCAGGGGGCCTACAACATCGACGTGGTTGCTGTGGTG
AACGACACAGTGGGCACCATGATGGGCTGTGAGCCGGGGGTCAGGCCGTGTGAGGTTGGG
CTAGTTGTAGACACGGGCACCAACGCGTGTTACATGGAGGAGGCACGGCATGTGGCAGTG
CTGGACGAAGACCGGGGCCGCGTCTGCGTCAGCGTCGAGTGGGGCTCCTTAAGCGATGAT
GGGGCGCTGGGACCAGTGCTGACCACCTTCGACCATACCCTGGACCATGAGTCCCTGAAT
CCTGGTGCTCAGAGGTTTGAGAAGATGATCGGAGGCCTGTACCTGGGTGAGCTGGTGCGG
CTGGTGCTGGCTCACTTGGCCCGGTGTGGGGTCCTCTTTGGTGGCTGCACCTCCCCTGCC
CTGCTGAGCCAAGGCAGCATCCTCCTGGAACACGTGGCTGAGATGGAGGACCCCTCTACT
GGGGCAGCCCGTGTCCATGCTATCCTGCAGGACTTGGGCCTGAGCCCTGGGGCTTCGGAT
GTTGAGCTTGTGCAGCACGTCTGTGCGGCCGTGTGCACGCGGGCTGCCCAGCTCTGTGCT
GCCGCCCTGGCCGCTGTTCTCTCCTGCCTCCAGCACAGCCGGGAGCAACAAACACTCCAG
GTTGCTGTGGCCACCGGAGGCCGAGTGTGTGAGCGGCACCCCAGGTTCTGCAGCGTCCTG
CAGGGGACAGTGATGCTCCTGGCCCCGGAATGCGATGTCTCCTTAATCCCCTCTGTGGAT
GGTGGTGGCCGGGGAGTGGCGATGGTGACTGCTGTGGCTGCCCGTCTGGCTGCCCACCGG
CGCCTGCTGGAGGAGACCCTGGCCCCATTCCGGTTGAACCATGATCAACTGGCTGCGGTT
CAGGCACAGATGCGGAAGGCCATGGCCAAGGGGCTCCGAGGGGAGGCCTCCTCCCTTCGC
ATGCTGCCCACTTTCGTCCGGGCCACCCCTGACGGCAGCGAGCGAGGGGATTTCCTGGCC
CTGGACCTCGGGGGCACGAACTTCCGTGTCCTCCTGGTACGTGTGACCACAGGCGTGCAG
ATCACCAGCGAGATCTACTCCATTCCCGAGACTGTGGCCCAGGGTTCTGGGCAGCAGCTC
TTTGACCACATCGTGGACTGCATCGTGGACTTCCAGCAGAAGCAGGGCCTGAGCGGGCAG
AGCCTCCCACTGGGTTTTACCTTCTCCTTCCCATGTAGGCAGCTTGGCCTAGACCAGGGC
ATCCTCCTGAACTGGACCAAGGGTTTCAAGGCATCAGACTGCGAGGGCCAAGATGTCGTG
AGTCTGTTGCGGGAAGCCATCACTCGCAGACAGGCAGTGGAGCTGAATGTGGTTGCCATT
GTCAATGACACGGTGGGGACCATGATGTCCTGTGGCTATGAGGACCCCCGTTGCGAGATA
GGCCTCATTGTCGGAACCGGCACCAATGCCTGCTACATGGAGGAGCTCCGGAATGTGGCG
GGCGTGCCTGGGGACTCAGGCCGCATGTGCATCAACATGGAGTGGGGCGCCTTTGGGGAC
GATGGCTCTCTGGCCATGCTCAGCACCCGCTTTGATGCAAGTGTGGACCAGGCGTCCATC
AACCCCGGCAAGCAGAGGTTTGAAAAGATGATCAGCGGCATGTACCTGGGGGAGATCGTC
CGCCACATCCTTTTACATTTAACCAGCCTTGGCGTTCTCTTCCGGGGCCAGCAGATCCAG
CGCCTTCAGACCAGGGACATCTTCAAGACCAAGTTCCTCTCTGAGATCGAAAGTGACAGC
CTGGCCCTGCGGCAGGTCCGAGCCATCCTAGAGGATCTGGGGCTACCCCTGACCTCAGAT
GACGCCCTGATGGTGCTAGAGGTGTGCCAGGCTGTGTCCCAGAGGGCTGCCCAGCTCTGT
GGGGCGGGTGTAGCTGCCGTGGTGGAGAAGATCCGGGGGAACCGGGGCCTGGAAGAGCTG
GCAGTGTCTGTGGGGGTGGATGGAACGCTCTACAAGCTGCACCCGCGCTTCTCCAGCCTG
GTGGCGGCCACAGTGCGGGAGCTGGCCCCTCGCTGTGTGGTCACGTTCCTGCAGTCAGAG
GATGGGTCCGGCAAAGGTGCGGCCCTGGTCACCGCTGTTGCCTGCCGCCTTGCGCAGTTG
ACTCGTGTCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U51333

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_3_Locus:
5q35.2

# Metabolic_Enzyme_3_SNPs:
rs35610191; rs2278492; rs6875296; rs6861925; rs691141; rs691541; rs11135005; rs493578; rs691583; rs691057; rs522150; rs4976661; rs2278493; rs4976662; rs539822; rs691276; rs7716812; rs541807; rs12519232; rs479270; rs692200; rs10064961; rs3792729; rs12187462; rs691044; rs2278494; rs7736787; rs691693; rs691866; rs547798; rs3762971; rs812246; rs692129; rs2304514; rs35676647; rs34127573; rs494450; rs34497240; rs35226830; rs34468066; rs36002077; rs576380; rs34792080; rs36056969; rs6897020; rs35738781; rs4976631; rs35622796; rs4976663; rs691009; rs691473; rs34391089; rs3792730; rs35417166; rs691477; rs10056854; rs3762972; rs3762973; rs10543717; rs35180023; rs1043930; rs10475632; rs10475633; rs11953674; rs12422; rs1472920; rs2292255; rs2292256; rs2292257; rs2304515; rs2304516; rs2304517; rs2940531; rs2962835; rs2962844; rs2962845; rs3736431; rs3736432; rs3762974; rs475533; rs478253; rs490368; rs4976630; rs506370; rs690885; rs692011; rs9313744

# Metabolic_Enzyme_3_General_References:
8812439; 8717435

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5342

# Metabolic_Enzyme_4_Name:
Nucleoside diphosphate kinase 7

# Metabolic_Enzyme_4_Synonyms:
NDK 7; NDP kinase 7; nm23-H7

# Metabolic_Enzyme_4_Gene_Name:
NME7

# Metabolic_Enzyme_4_Protein_Sequence:
>Nucleoside diphosphate kinase 7
MNHSERFVFIAEWYDPNASLLRRYELLFYPGDGSVEMHDVKNHRTFLKRTKYDNLHLEDL
FIGNKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAISKAGEIIEIINKAGFTI
TKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGPAN
SGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCT
CCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMVT
EMYSGPCVAMEIQQNNATKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLP
EDGLLEVQYFFKILDN

# Metabolic_Enzyme_4_Number_of_Residues:
376

# Metabolic_Enzyme_4_Molecular_Weight:
42492

# Metabolic_Enzyme_4_Theoretical_pI:
6.44

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  nucleoside diphosphate kinase activity
 ||
>>>
Process:  CTP biosynthesis
Process:  nucleoside triphosphate metabolism
Process:  nucleoside triphosphate biosynthesis
Process:  ribonucleoside triphosphate biosynthesis
Process:  pyrimidine ribonucleoside triphosphate biosynthesis
Process:  UTP biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside triphosphate biosynthesis
Process:  purine ribonucleoside triphosphate biosynthesis
Process:  GTP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

# Metabolic_Enzyme_4_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_4_Reaction:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00334:NDK

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.7.4.6

# Metabolic_Enzyme_4_GenBank_ID_Protein:
4960169

# Metabolic_Enzyme_4_SwissProt_ID:
NDK7_HUMAN (Q9Y5B8)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
NME7

# Metabolic_Enzyme_4_Geneatlas_id:
NME7

# Metabolic_Enzyme_4_hgnc_id:
HGNC:20461

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>1131 bp
ATGAATCATAGTGAAAGATTCGTTTTCATTGCAGAGTGGTATGATCCAAATGCTTCACTT
CTTCGACGTTATGAGCTTTTATTTTACCCAGGGGATGGATCTGTTGAAATGCATGATGTA
AAGAATCATCGCACCTTTTTAAAGCGGACCAAATATGATAACCTGCACTTGGAAGATTTA
TTTATAGGCAACAAAGTGAATGTCTTTTCTCGACAACTGGTATTAATTGACTATGGGGAT
CAATATACAGCTCGCCAGCTGGGCAGTAGGAAAGAAAAAACGCTAGCCCTAATTAAACCA
GATGCAATATCAAAGGCTGGAGAAATAATTGAAATAATAAACAAAGCTGGATTTACTATA
ACCAAACTCAAAATGATGATGCTTTCAAGGAAAGAAGCATTGGATTTTCATGTAGATCAC
CAGTCAAGACCCTTTTTCAATGAGCTGATCCAGTTTATTACAACTGGTCCTATTATTGCC
ATGGAGATTTTAAGAGATGATGCTATATGTGAATGGAAAAGACTGCTGGGACCTGCAAAC
TCTGGAGTGGCACGCACAGATGCTTCTGAAAGCATTAGAGCCCTCTTTGGAACAGATGGC
ATAAGAAATGCAGCGCATGGCCCTGATTCTTTTGCTTCTGCGGCCAGAGAAATGGAGTTG
TTTTTTCCTTCAAGTGGAGGTTGTGGGCCGGCAAACACTGCTAAATTTACTAATTGTACC
TGTTGCATTGTTAAACCCCATGCTGTCAGTGAAGGACTGTTGGGAAAGATCCTGATGGCT
ATCCGAGATGCAGGTTTTGAAATCTCAGCTATGCAGATGTTCAATATGGATCGGGTTAAT
GTTGAGGAATTCTATGAAGTTTATAAAGGAGTAGTGACCGAATATCATGACATGGTGACA
GAAATGTATTCTGGCCCTTGTGTAGCAATGGAGATTCAACAGAATAATGCTACAAAGACA
TTTCGAGAATTTTGTGGACCTGCTGATCCTGAAATTGCCCGGCATTTACGCCCTGGAACT
CTCAGAGCAATCTTTGGTAAAACTAAGATCCAGAATGCTGTTCACTGTACTGATCTGCCA
GAGGATGGCCTATTAGAGGTTCAATACTTCTTCAAGATCTTGGATAATTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF153191

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_4_Locus:
1q24

# Metabolic_Enzyme_4_SNPs:
rs7538259; rs2176473; rs10494477; rs12057602; rs10800440; rs10919151; rs10919144; rs10919147; rs10800439; rs1208327; rs9628661; rs1209731; rs10919149; rs929132; rs10800433; rs929133; rs1517750; rs4264046; rs12752953; rs17349579; rs16862095; rs3213586; rs7415756; rs10800438; rs12043489; rs7528142; rs12097682; rs7556463; rs1850525; rs1400838; rs10919140; rs10919150; rs3213587; rs1200063; rs12097151; rs10800436; rs11810815; rs10158131; rs16862093; rs12733001; rs16862091; rs10800437; rs12567342; rs4529780; rs4140539; rs16862089; rs12029566; rs12081893; rs9887925; rs6662237; rs7412125; rs17345412; rs1517749; rs12033078; rs17345426; rs6694582; rs4534447; rs6686204; rs12046139; rs12401962; rs10800434; rs1856302; rs7412126; rs10919145; rs12029800; rs11807896; rs12140572; rs16862101; rs12043545; rs10919141; rs4454599; rs10919146; rs16862097; rs12038609; rs10800435; rs12042990; rs4140538; rs10465575; rs2090514; rs2211017; rs909930; rs2143287; rs1419322; rs1358712; rs1024341; rs724049; rs2268048; rs2179492; rs2179491; rs2037250; rs909931; rs1200079; rs1200164; rs10919076; rs10800408; rs7541564; rs3766054; rs12075832; rs10800432; rs3820057; rs3737681; rs3766074; rs12568636; rs3753298; rs1011638; rs9887854; rs12124168; rs12124144; rs2420015; rs958581; rs3753300; rs3766062; rs3820053; rs1419323; rs3766065; rs3820056; rs9988604; rs1018832; rs2420010; rs7518554; rs12130764; rs12564596; rs1208375; rs4656654; rs994986; rs12071277; rs12118611; rs12140967; rs4656655; rs10919084; rs12691502; rs12129969; rs3766084; rs745921; rs6695177; rs6695252; rs12082810; rs1320965; rs3820055; rs2001155; rs10919074; rs3766066; rs4656181; rs3766057; rs1200160; rs1415928; rs10919085; rs10800429; rs724048; rs3766089; rs7541675; rs3753297; rs10919127; rs9887916; rs12117884; rs3766085; rs10919079; rs4656653; rs4656659; rs1320964; rs10800412; rs745922; rs2420016; rs3766060; rs10919075; rs2300157; rs3766063; rs10919116; rs12072226; rs10919093; rs11802143; rs10800411; rs10919128; rs12026996; rs1080268; rs10800418; rs1018831; rs3766086; rs12127305; rs7541700; rs10919134; rs11801853; rs4656661; rs3766077; rs3766071; rs10458388; rs4656665; rs10919124; rs9887857; rs12747242; rs3766059; rs17349222; rs4140540; rs3766075; rs2179490; rs6688038; rs7526337; rs10919110; rs10919090; rs12121994; rs12095171; rs3766083; rs10753786; rs4656177; rs9804101; rs12083287; rs12755385; rs10919129; rs10919115; rs12144832; rs12031371; rs10919087; rs1080267; rs12082618; rs10919092; rs12744184; rs12039443; rs12145146; rs3766053; rs10919114; rs1320967; rs4656662; rs12067072; rs7542713; rs7520186; rs17349460; rs6427180; rs16862081; rs10800421; rs17345170; rs1591734; rs11802239; rs10732287; rs3766067; rs10919118; rs12354315; rs12067018; rs2040446; rs17345156; rs10919122; rs2901030; rs7528751; rs12756799; rs12125501; rs12410548; rs2300158; rs12083075; rs932394; rs17349271; rs2420009; rs11808938; rs10800425; rs12084964; rs7521582; rs17349467; rs10800430; rs12751379; rs4589164; rs12724494; rs12145939; rs1200082; rs2001156; rs17345107; rs3753299; rs3766052; rs12562404; rs3766061; rs7552323; rs12561922; rs4656658; rs4656660; rs1208369; rs7540607; rs1208370; rs1320966; rs4656651; rs909929; rs2300160; rs3766090; rs10800407; rs7521338; rs3766064; rs10919135; rs12120493; rs17349439; rs3766070; rs932395; rs10919082; rs6427179; rs10919120; rs6703463; rs7516097; rs1208373; rs12744655; rs10442644; rs1080266; rs12143193; rs10800424; rs3766069; rs16861990; rs12145897; rs10919086; rs7552484; rs4656656; rs3766082; rs1208377; rs12081283; rs12086983; rs12129979; rs16828170; rs12086665; rs3766076; rs10919123; rs10081959; rs12072953; rs12029857; rs12145226; rs12564558; rs12405725; rs12753710; rs2300159; rs16828165; rs7522760; rs10800431; rs1200086; rs1320968; rs10919088; rs10919099; rs2420014; rs12121346; rs12121185; rs17517699; rs12097793; rs16861993; rs7532362; rs10753785; rs4656178; rs12736886; rs6701686; rs12120007; rs4385775; rs12057856; rs1829286; rs6667882; rs12724093; rs1830492; rs1200076; rs12126266; rs3766094; rs1830494; rs12728466; rs2420008; rs16862058; rs2012757; rs16861997; rs1200161; rs6704482; rs13376083; rs17345184; rs12042082; rs11802117; rs4562680; rs10919130; rs16862077; rs12083249; rs12125921; rs12739920; rs3753293; rs12124064; rs6688139; rs10800415; rs12060959; rs1200084; rs11808274; rs12127613; rs12143965; rs12076469; rs12733626; rs7544446; rs6675220; rs7526721; rs12039104; rs13375997; rs12410456; rs10158265; rs12125985; rs12744341; rs4656669; rs4656657; rs10919111; rs10081960; rs1829287; rs1856303; rs12117559; rs12144705; rs12084549; rs10919105; rs7538158; rs1208371; rs1200073; rs12086292; rs3766078; rs7515326; rs11810319; rs16862000; rs1200085; rs10489417; rs12129132; rs11803007; rs10800410; rs12142784; rs6695674; rs10919104; rs12736110; rs10800417; rs12752748; rs4656666; rs12092528; rs10919089; rs12066375; rs7519735; rs1200077; rs12066426; rs12023291; rs1830493; rs2066001; rs1200083; rs12083296; rs9988595; rs4656180; rs12068152; rs12065226; rs12145969; rs12045202; rs10919119; rs10800406; rs1200162; rs12116683; rs10800414; rs7533349; rs35393101; rs1400840; rs10800423; rs1890260; rs12143131; rs12758208; rs12123168; rs12084957; rs12084793; rs13374340; rs4445529; rs3834009; rs12089118; rs10919132; rs12036968; rs12031830; rs35448601; rs12073439; rs10919102; rs3766079; rs12408636; rs4656652; rs12025566; rs12724802; rs7418266; rs1591733; rs16862051; rs2420012; rs7529937; rs10919078; rs1936533; rs12724863; rs12029428; rs12074013; rs12143135; rs12126032; rs7532255; rs12082748; rs10919095; rs12745997; rs2154125; rs12141917; rs1208374; rs12086569; rs12403181; rs34651513; rs12405185; rs11806445; rs2032044; rs12029853; rs10800420; rs6685384; rs1208376; rs12120960; rs12745732; rs12065030; rs10800413; rs12141151; rs7521964; rs12033035; rs12080100; rs7413522; rs2157597; rs1419324; rs12130858; rs3766088; rs10919108; rs2040445; rs12065884; rs3766055; rs9633334; rs11585212; rs1400839; rs11584076; rs12124744; rs4656664; rs2012763; rs1200080; rs12739337; rs12059281; rs2152980; rs12741540; rs35220898; rs1830495; rs12135928; rs6686006; rs1200075; rs9887903; rs7547686; rs12410241; rs2050119; rs4656179; rs6692824; rs10458394; rs1200081; rs10919094; rs2420011; rs11578912; rs12728614; rs10919101; rs12410387; rs4656668; rs1589113; rs10919106; rs12740040; rs3820054; rs10737545; rs10919133; rs12116551; rs12741323; rs2152979; rs11809256; rs10919136; rs12407865; rs10800419; rs12121395; rs1200074; rs10696699; rs10919142; rs28677096; rs35109195; rs34944961; rs12568544; rs1200060; rs36072396; rs12036426; rs34095348; rs12742330; rs10696698; rs12751929; rs1572616; rs12757669; rs1400837; rs9726842; rs12738217; rs34647634; rs10919143; rs34710865; rs35019256; rs12567068; rs17349586; rs12097260; rs12745541; rs35406371; rs2176474; rs4287233; rs1200064; rs34056724; rs35999944; rs11809378; rs5778612; rs34714244; rs35435858; rs10696697; rs7417281; rs12742459; rs34689938; rs34701797; rs34546589; rs34373126; rs12061080; rs34088496; rs6687062; rs35180550; rs34801027; rs12028433; rs35326875; rs35641779; rs35683059; rs12738248; rs34676722; rs12032783; rs34340382; rs5778613; rs35728129; rs12742460; rs35003708; rs35940727; rs34450667; rs35622699; rs12742307; rs4589163; rs7520046; rs10919148; rs12760656; rs34870158; rs12145350; rs3213585; rs34818994; rs12738203; rs12725912; rs12738211; rs34930817; rs36023090; rs12744362; rs12044982; rs35893899; rs11811461; rs3030219; rs12738256; rs35009499; rs2901032; rs34195074; rs3950167; rs12124738; rs34792089; rs10800428; rs6685857; rs12725542; rs10575933; rs34543492; rs34605921; rs35320565; rs34440651; rs34764111; rs12723742; rs10689301; rs35447001; rs3766068; rs34032351; rs12086104; rs12143790; rs35493809; rs35509277; rs5778607; rs34993736; rs36079696; rs1476065; rs35207260; rs35110010; rs35244822; rs35098610; rs35133990; rs12071302; rs35637907; rs35816758; rs10919109; rs35495283; rs36144136; rs1208368; rs12088527; rs3962194; rs35165011; rs11373823; rs35469833; rs12122348; rs34578296; rs12063719; rs34984299; rs7514729; rs34127028; rs12756556; rs35213162; rs12065826; rs1208287; rs10919083; rs36102044; rs34016668; rs36096137; rs34654692; rs34369716; rs34323371; rs35261574; rs12736817; rs35710695; rs35893113; rs36125519; rs5778603; rs35067189; rs1857567; rs35539429; rs35646253; rs12120344; rs4300284; rs12751062; rs12753699; rs6671966; rs10545228; rs11805562; rs34472735; rs34691590; rs12403013; rs12025233; rs34072833; rs10540645; rs12061405; rs35458577; rs35383178; rs34581963; rs35037551; rs12078340; rs1476063; rs10629320; rs35352275; rs12073338; rs35153537; rs2090513; rs12739381; rs35471075; rs12072404; rs5778610; rs36183681; rs7514582; rs12757427; rs35452880; rs35762400; rs10645332; rs35536594; rs34816984; rs12028197; rs35933108; rs35867722; rs11323879; rs12144230; rs3216527; rs35631014; rs34735555; rs28440806; rs12129567; rs3981316; rs35970886; rs36013240; rs11353985; rs34219745; rs12740205; rs28454510; rs3835442; rs12061279; rs36042457; rs12121788; rs12063056; rs10593825; rs28676800; rs34392894; rs3981317; rs34255929; rs35153249; rs34847919; rs34131734; rs12058325; rs1476064; rs2420013; rs10575934; rs10919098; rs12751804; rs36017709; rs12118918; rs33970981; rs12089602; rs34332810; rs5778602; rs3766072; rs13374428; rs28778909; rs34599560; rs12139905; rs35862763; rs2090512; rs975991; rs16861955; rs12748602; rs35501501; rs3981312; rs35375125; rs12751571; rs35718930; rs718031; rs34033983; rs33951688; rs36179730; rs28738730; rs12030810; rs1211418; rs12133517; rs7529148; rs12071122; rs12072082; rs10919131; rs34123578; rs12070666; rs12117362; rs3962195; rs12081023; rs3981318; rs34997639; rs12750161; rs12126933; rs16861948; rs36010825; rs4567334; rs35144581; rs34235429; rs34246691; rs36056596; rs12743456; rs12730917; rs7548520; rs6703464; rs12753059; rs6679084; rs34750504; rs12753198; rs36176661; rs35091267; rs12044575; rs36040633; rs36061305; rs2901033; rs3835443; rs34577710; rs35527028; rs4656667; rs12738167; rs12067139; rs34178237; rs35653716; rs3835448; rs34962461; rs12038761; rs12076510; rs3060501; rs35658009; rs10686255; rs3766058; rs12736723; rs10919100; rs28648500; rs3060535; rs34218127; rs36013764; rs34215866; rs10800427; rs35272114; rs12048188; rs35606300; rs12035804; rs12743588; rs4497270; rs34408435; rs12081562; rs12071224; rs12758455; rs11267929; rs34975352; rs12030541; rs34254032; rs1208372; rs34313790; rs34089647; rs36047625; rs11446636; rs3766048; rs7537097; rs12068499; rs2095734; rs2227246; rs3060508; rs35586898; rs34276437; rs12740226; rs34794230; rs34985260; rs34376054; rs12758258; rs35983758; rs28495280; rs35396646; rs12735503; rs2066000; rs12735442; rs10919107; rs2187963; rs12039156; rs12751407; rs34669907; rs7555888; rs12759617; rs35977750; rs34473903; rs12061069; rs12725978; rs34809821; rs6664272; rs34877424; rs35416900; rs3981314; rs41442344; rs34222155; rs36189651; rs12118645; rs7522781; rs12140995; rs1999880; rs7533257; rs12750328; rs34748133; rs34576386; rs35423959; rs35497125; rs7532955; rs12063863; rs5778609; rs35092444; rs12730920; rs35870215; rs2138897; rs36140409; rs1200163; rs35680826; rs35625187; rs35000842; rs1209733; rs34492487; rs4614315; rs12047231; rs34253473; rs3981313; rs34481631; rs12724812; rs35834275; rs10800416; rs12076824; rs35470935; rs34611209; rs36040265; rs10919125; rs12144756; rs12027561; rs12143963; rs12753816; rs36103852; rs35682595; rs3766092; rs12729048; rs12074492; rs35735494; rs12049161; rs34923262; rs12743782; rs34342694; rs36083778; rs35952160; rs12401966; rs34087265; rs1208286; rs12038798; rs13374140; rs3981310; rs34240425; rs12735330; rs1200078; rs11295689; rs12088672; rs10919097; rs12085114; rs12723917; rs3981308; rs12744668; rs34994135; rs12040813; rs34829200; rs3766049; rs12041879; rs35639586; rs12728447; rs3835444; rs12068430; rs3981319; rs3835447; rs35093802; rs36192558; rs35686505; rs34848646; rs12760335; rs34194554; rs34240559; rs12740501; rs35232870; rs34693497; rs35973200; rs35816854; rs34527707; rs12734206; rs6691226; rs35271076; rs6685556; rs12062884; rs3060581; rs35784194; rs4471312; rs12093387; rs34419988; rs35763380; rs3820058; rs10919091; rs7533251; rs35127583; rs34062135; rs35320726; rs7522680; rs12142454; rs2268047; rs4284298; rs2187964; rs12145193; rs34748330; rs34248820; rs35956345; rs35758825; rs3962193; rs34882155; rs12125057; rs35870776; rs34054662; rs12735250; rs34990519; rs12045783; rs36154866; rs34147690; rs34364140; rs3981315; rs10579498; rs12045803; rs35249110; rs34732093; rs35877266; rs10919126; rs34250651; rs34176173; rs2901031; rs12731520; rs12087425; rs34830831; rs5778608; rs12070031; rs3835446; rs34848249; rs12745978; rs12748624; rs3937415; rs35159355; rs35295807; rs34889848; rs11359012; rs12738172; rs35977405; rs10158861; rs3981311; rs12076519; rs34926802; rs7533247; rs35346029; rs36175137; rs12734943; rs12067351; rs34627071; rs3831767; rs12757242; rs12063495; rs35524440; rs12760266; rs10550759; rs6698149; rs12752495; rs12753703; rs3766093; rs12086231; rs34321069; rs12021696; rs34469836; rs7514545; rs34045951; rs34417084; rs6686677; rs34903596; rs12037211; rs3981320; rs11410749; rs12086238; rs34973357; rs34754767; rs34758802; rs36186288; rs12735021; rs3981309; rs35503426; rs35774511; rs12066921; rs5778611; rs11589565; rs7519279; rs34417566; rs35119166; rs12118533; rs5778604; rs35997350; rs3835370; rs3766091; rs12739909; rs34165486; rs36013941; rs1028180; rs10494478; rs10800441; rs10919064; rs10919065; rs10919070; rs10919071; rs10919073; rs10919153; rs10919155; rs10919156; rs1138486; rs11800843; rs11809180; rs1200156; rs1200157; rs1200158; rs1200159; rs12022617; rs12023892; rs12024897; rs12026287; rs12035622; rs12038258; rs12070626; rs12084554; rs12091; rs12128543; rs12134211; rs12137282; rs12138150; rs12406083; rs12563090; rs12565299; rs14824; rs1517748; rs1892094; rs1980198; rs2000321; rs2275299; rs2275300; rs2745209; rs2854730; rs2901029; rs3180378; rs3753302; rs3766042; rs3766044; rs3766045; rs3766095; rs3818844; rs4656670; rs4656671; rs6693263; rs7517394; rs7527703; rs7539415; rs7539798; rs7540067; rs7553526; rs968304

# Metabolic_Enzyme_4_General_References:
Not Available

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5346

# Metabolic_Enzyme_5_Name:
Nucleoside diphosphate kinase 6

# Metabolic_Enzyme_5_Synonyms:
NDK 6; NDP kinase 6; nm23-H6; Inhibitor of p53-induced apoptosis-alpha; IPIA-alpha

# Metabolic_Enzyme_5_Gene_Name:
NME6

# Metabolic_Enzyme_5_Protein_Sequence:
>Nucleoside diphosphate kinase 6
MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWRKEDCQRFY
REHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMGPTRVFRARHVAPDSIRGSFG
LTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQLRCGPVCYSPEGGVHYVAGT
GGLGPA

# Metabolic_Enzyme_5_Number_of_Residues:
186

# Metabolic_Enzyme_5_Molecular_Weight:
21142

# Metabolic_Enzyme_5_Theoretical_pI:
8.49

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  nucleoside diphosphate kinase activity
 ||
>>>
Process:  CTP biosynthesis
Process:  nucleoside triphosphate metabolism
Process:  nucleoside triphosphate biosynthesis
Process:  ribonucleoside triphosphate biosynthesis
Process:  pyrimidine ribonucleoside triphosphate biosynthesis
Process:  UTP biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside triphosphate biosynthesis
Process:  purine ribonucleoside triphosphate biosynthesis
Process:  GTP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis

# Metabolic_Enzyme_5_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_5_Reaction:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00334:NDK

# Metabolic_Enzyme_5_Signals:
1-24

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.7.4.6

# Metabolic_Enzyme_5_GenBank_ID_Protein:
3228530

# Metabolic_Enzyme_5_SwissProt_ID:
NDK6_HUMAN (O75414)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
NME6

# Metabolic_Enzyme_5_Geneatlas_id:
NME6

# Metabolic_Enzyme_5_hgnc_id:
HGNC:20567

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Not Available

# Metabolic_Enzyme_5_Gene_Sequence:
>561 bp
ATGGCCTCAATCTTGCGAAGCCCTCAGGCTCTCCAGCTCACTCTAGCCCTGATCAAGCCT
GACGCAGTCGCCCATCCACTGATTCTGGAGGCTGTTCATCAGCAGATTCTAAGCAACAAG
TTCCTGATTGTACGAATGAGAGAACTACTGTGGAGAAAGGAAGATTGCCAGAGGTTTTAC
CGAGAGCATGAAGGGCGTTTTTTCTATCAGAGGCTGGTGGAGTTCATGGCCAGCGGGCCA
ATCCGAGCCTACATCCTTGCCCACAAGGATGCCATCCAGCTCTGGAGGACGCTCATGGGA
CCCACCAGAGTGTTCCGAGCACGCCATGTGGCCCCAGATTCTATCCGTGGGAGTTTCGGC
CTCACTGACACCCGCAACACCACCCATGGTTCGGACTCTGTGGTTTCAGCCAGCAGAGAG
ATTGCAGCCTTCTTCCCTGACTTCAGTGAACAGCGCTGGTATGAGGAGGAAGAGCCCCAG
TTGCGCTGTGGCCCTGTGTGCTATAGCCCAGAGGGAGGTGTCCACTATGTAGCTGGAACA
GGAGGCCTAGGACCAGCCTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AF051941

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_5_Locus:
3p21

# Metabolic_Enzyme_5_SNPs:
rs1134867; rs3197223; rs4479622; rs13084616; rs13085251; rs2541; rs13079728; rs34946886; rs13067450; rs4392440; rs4511915; rs13066758; rs4336143; rs7621785; rs35190747; rs34630841; rs13082859; rs35784663; rs11545439; rs1134866; rs28684386; rs35512171; rs34589064; rs34523942; rs34621890; rs34763162; rs34399672; rs35679809; rs9874212; rs10635171; rs7616884; rs5848850; rs36075665; rs13315223; rs34146962; rs35493895; rs34373799; rs34594819; rs34073994; rs35297395; rs13318895; rs34359447; rs4511916; rs6793239; rs6794644; rs6801801; rs6808458; rs7620674; rs7624450; rs7632297; rs9818605; rs9823457; rs9833309; rs9834073; rs9881724

# Metabolic_Enzyme_5_General_References:
10453732

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
6173

# Metabolic_Enzyme_6_Name:
Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor

# Metabolic_Enzyme_6_Synonyms:
Succinyl-CoA synthetase, betaG chain; SCS-betaG; GTP- specific succinyl-CoA synthetase subunit beta

# Metabolic_Enzyme_6_Gene_Name:
SUCLG2

# Metabolic_Enzyme_6_Protein_Sequence:
>SuccinylCoA ligase GDPforming betachain, mitochondrial precursor
MASPVAAQAGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQEYQSKKLMSDNGVRVQRFF
VADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNVVGQLAKQM
IGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEV
AASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQV
EVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKYDLKYIGLD
GNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILV
NIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTNVQEAQKILNNSGLPITSAIDLED
AAKKAVASVAKK

# Metabolic_Enzyme_6_Number_of_Residues:
432

# Metabolic_Enzyme_6_Molecular_Weight:
46511

# Metabolic_Enzyme_6_Theoretical_pI:
6.18

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_6_Specific_Function:
GTP + succinate + CoA = GDP + phosphate + succinyl-CoA

# Metabolic_Enzyme_6_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00640  Propanoate metabolism

# Metabolic_Enzyme_6_Reaction:
GTP + succinate + CoA = GDP + phosphate + succinyl-CoA

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF08442:ATP-grasp_2;
PF00549:Ligase_CoA

# Metabolic_Enzyme_6_Signals:
1-29

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 6.2.1.4

# Metabolic_Enzyme_6_GenBank_ID_Protein:
133777003

# Metabolic_Enzyme_6_SwissProt_ID:
SUCB2_HUMAN (Q96I99)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
SUCLG2

# Metabolic_Enzyme_6_Geneatlas_id:
SUCLG2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:11450

# Metabolic_Enzyme_6_PDB_ID:
1EUC

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_6_Gene_Sequence:
>1155 bp
ATGTCTGACAACGGAGTGAGAGTTCAAAGATTCTTTGTAGCAGACACTGCAAATGAAGCT
CTCGAGGCTGCTAAGAGACTAAATGCAAAAGAAATTGTTTTAAAAGCCCAGATCTTAGCT
GGAGGAAGAGGAAAAGGTGTCTTCAATAGTGGTTTGAAAGGAGGTGTTCATTTAACAAAA
GACCCTAATGTTGTGGGACAGCTGGCTAAACAGATGATTGGGTACAATCTAGCGACAAAA
CAAACTCCAAAAGAAGGTGTGAAAGTTAACAAGGTGATGGTTGCTGAAGCCTTGGATATT
TCCAGAGAAACCTACCTGGCAATTCTGATGGACCGGTCCTGCAATGGCCCCGTGCTGGTG
GGCAGCCCCCAGGGGGGCGTCGACATTGAAGAGGTGGCTGCTTCAAACCCGGAGCTCATT
TTTAAGGAGCAAATTGACATTTTTGAAGGAATAAAGGACAGCCAAGCTCAGCGGATGGCC
GAAAATCTAGGCTTCGTTGGGCCTTTGAAAAGCCAGGCTGCAGATCAAATTACGAAGCTG
TATAATCTCTTCCTGAAAATTGATGCTACTCAGGTGGAAGTGAATCCCTTTGGTGAAACT
CCAGAAGGACAAGTTGTCTGTTTTGATGCCAAGATAAACTTTGATGACAACGCAGAATTC
CGACAAAAAGACATATTTGCTATGGACGACAAATCAGAGAATGAGCCCATTGAAAATGAA
GCTGCCAAATATGATCTAAAATACATAGGACTAGATGGGAACATTGCCTGCTTTGTGAAT
GGTGCTGGGCTCGCCATGGCTACTTGTGATATCATTTTCCTTAATGGTGGGAAGCCAGCC
AACTTCTTGGATCTTGGAGGTGGTGTAAAGGAAGCTCAAGTATATCAAGCATTCAAATTG
CTCACAGCTGATCCTAAGGTTGAAGCCATCCTTGTCAATATATTTGGTGGTATCGTCAAC
TGTGCCATCATTGCCAATGGGATCACCAAAGCCTGCCGGGAGCTAGAACTCAAGGTGCCC
CTGGTGGTCCGGCTTGAAGGAACCAACGTCCAAGAGGCCCAGAAGATACTCAACAACAGC
GGACTCCCCATTACTTCAGCCATTGACCTGGAGGATGCAGCCAAGAAGGCTGTGGCCAGT
GTGGCCAAGAAGTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
BC007716

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_6_Locus:
3p14.1

# Metabolic_Enzyme_6_SNPs:
rs7623258; rs9843840; rs13318110; rs2122479; rs1868674; rs1463231; rs1376028; rs935734; rs2362455; rs2242022; rs881949; rs881948; rs6806897; rs6797199; rs4355299; rs9867357; rs6767968; rs7644842; rs1376030; rs6787853; rs9818900; rs9836781; rs6766403; rs13092662; rs6792270; rs6787642; rs9814167; rs11706848; rs6808106; rs9811187; rs9824641; rs9831840; rs1463233; rs9875474; rs9835458; rs7642995; rs9877255; rs2167181; rs2167180; rs2242020; rs9810550; rs7629728; rs9871141; rs2363082; rs1823476; rs6794625; rs1065401; rs6779395; rs6787200; rs7651495; rs1065399; rs9813992; rs2242019; rs2198015; rs9828970; rs6797460; rs7653350; rs1065400; rs2290175; rs6790570; rs10510965; rs9309845; rs9853025; rs12714500; rs13065696; rs6799003; rs2122477; rs7643466; rs9309843; rs11914829; rs7646094; rs11706911; rs2198016; rs1376029; rs6789513; rs1450345; rs2242021; rs9833802; rs9865853; rs2362454; rs17046784; rs6767025; rs2167179; rs6778266; rs7630015; rs2362453; rs11712921; rs1463232; rs9815919; rs17046748; rs9830311; rs6786211; rs11712851; rs6791337; rs7434004; rs7652308; rs6774971; rs7638233; rs9835259; rs9808978; rs1814519; rs9309856; rs7610446; rs12632111; rs9832061; rs7640362; rs9866040; rs17046744; rs6790771; rs9872806; rs11717561; rs7610369; rs2218796; rs13072200; rs6800079; rs12495546; rs9839225; rs11127674; rs9864493; rs12635806; rs3206428; rs6793868; rs13315729; rs2290174; rs6788874; rs3206427; rs11707967; rs6798772; rs9683084; rs6797010; rs9882828; rs9882327; rs2084603; rs9839235; rs9845918; rs6772439; rs9681630; rs6798228; rs7648409; rs2634741; rs1552631; rs1928564; rs2290172; rs2634722; rs2772467; rs1490265; rs1928565; rs2634744; rs2772448; rs1974109; rs935735; rs2363084; rs2634738; rs2634732; rs2078020; rs2634743; rs2772471; rs1028950; rs2772464; rs2634737; rs2634742; rs2772468; rs12489287; rs2171934; rs4645146; rs9852251; rs11927204; rs2634725; rs4856868; rs9827838; rs7624455; rs6796037; rs2363091; rs1552626; rs9818109; rs7633790; rs7643394; rs9856294; rs2634730; rs6548542; rs7432317; rs2634734; rs12636825; rs6807618; rs4130105; rs6807734; rs1576397; rs4538392; rs4856877; rs7647085; rs7637465; rs6792584; rs4349513; rs9683384; rs1075642; rs4856869; rs9878672; rs12497038; rs2772457; rs1387867; rs9848013; rs6772251; rs7621788; rs4380422; rs2772462; rs9862781; rs4241439; rs2171933; rs2363086; rs4856859; rs4279119; rs7640284; rs9838227; rs9836548; rs1352656; rs6780493; rs2772450; rs9815209; rs4258984; rs2772447; rs4856791; rs2634733; rs1576398; rs6782194; rs6791198; rs2772465; rs2363087; rs4334654; rs7650892; rs6794091; rs745052; rs9862622; rs4856878; rs4292247; rs1590875; rs4527392; rs7628838; rs4241440; rs7623396; rs4856861; rs7616627; rs4132746; rs4479607; rs4423787; rs1552628; rs4856781; rs7620816; rs7627391; rs9309817; rs9860008; rs6791324; rs4443190; rs4521242; rs6787983; rs4856867; rs4588377; rs2772451; rs9873214; rs6548532; rs1610008; rs1590874; rs1352657; rs2363089; rs7620047; rs4856862; rs11919650; rs9869329; rs2885692; rs2772473; rs7629897; rs2634724; rs9880899; rs4856779; rs7620241; rs2634736; rs2076913; rs4443191; rs4438669; rs6548593; rs7629697; rs4327406; rs7429940; rs7618449; rs9872341; rs11923553; rs4485733; rs4856782; rs9818350; rs9873616; rs6548658; rs7612528; rs1552627; rs9851569; rs12714460; rs1352658; rs2772470; rs3923256; rs2076900; rs11920877; rs11705924; rs9811648; rs12632008; rs1552629; rs4076856; rs7629617; rs4553987; rs4515060; rs1028951; rs3902901; rs9811518; rs4856783; rs9822798; rs2772456; rs17046411; rs11127657; rs11127641; rs7652000; rs9851783; rs12635531; rs6788383; rs2363085; rs9828375; rs4132747; rs4371532; rs13064490; rs11926543; rs2362880; rs17046620; rs6548523; rs3923255; rs7616397; rs11709337; rs11928786; rs12492824; rs9823705; rs11127623; rs7635889; rs7628362; rs4856788; rs2634729; rs4132748; rs11923377; rs9876877; rs11127604; rs7645087; rs7636075; rs6548660; rs9844454; rs17808754; rs9871072; rs11928150; rs11922584; rs2634726; rs12630694; rs11712848; rs7641000; rs17808417; rs12495506; rs6796133; rs11924268; rs6784719; rs9878135; rs2253041; rs6794288; rs4856860; rs9851908; rs9849270; rs9867496; rs6785835; rs9878336; rs4856873; rs4856784; rs6770533; rs6769141; rs9861621; rs17046400; rs2772453; rs12635754; rs6791455; rs4377498; rs7623441; rs6784952; rs2772463; rs9813582; rs12489684; rs12497990; rs11705861; rs7635626; rs2772466; rs6810055; rs6768909; rs17046574; rs2101567; rs7636059; rs9809635; rs7648502; rs4856790; rs9825584; rs7630024; rs9867659; rs6548521; rs9839894; rs9823702; rs9853969; rs12485670; rs6803051; rs9880271; rs2772455; rs1928550; rs17046548; rs7643495; rs2772469; rs6787823; rs4320072; rs11710800; rs6780361; rs6772356; rs2101566; rs6774766; rs9856268; rs6766162; rs12488930; rs9816677; rs12496418; rs7631632; rs11923082; rs9813706; rs17046376; rs2363090; rs4856863; rs2634731; rs11706477; rs6772446; rs12497043; rs6773425; rs17195063; rs11922554; rs4130104; rs1928551; rs2772449; rs2250952; rs9836798; rs17046546; rs6548615; rs6768043; rs2634728; rs9849734; rs6797488; rs2634735; rs9853431; rs2885693; rs4856857; rs6794298; rs17194986; rs11929213; rs6810165; rs11919874; rs17043085; rs13069691; rs9861758; rs9824365; rs9847456; rs9852902; rs9856689; rs7642866; rs6810139; rs11919747; rs13059508; rs9858628; rs12490299; rs9880590; rs6802011; rs4856874; rs12488912; rs6787803; rs11917571; rs2772480; rs9815896; rs9852077; rs9871906; rs9824000; rs7609970; rs11920754; rs4515061; rs17028544; rs17046689; rs4286445; rs6548659; rs9851810; rs1868675; rs6786169; rs17046394; rs7637347; rs7642811; rs4856864; rs6768958; rs6762495; rs6781528; rs6771322; rs7642804; rs17808406; rs6769758; rs7631636; rs11709409; rs11923171; rs13314913; rs17046581; rs7651649; rs9826019; rs2250974; rs4640580; rs17809202; rs17046601; rs6802886; rs2772454; rs11919414; rs7623421; rs13322180; rs4856858; rs13085475; rs9830906; rs17194748; rs11922206; rs9830987; rs13317454; rs2290171; rs6774763; rs1028952; rs13087877; rs17807531; rs9846683; rs4856872; rs9843954; rs4334653; rs11915709; rs12489897; rs4856865; rs9682933; rs2363083; rs6802566; rs10222640; rs6769487; rs11711916; rs7645723; rs2251623; rs2249072; rs9810030; rs6773756; rs9713818; rs9882263; rs9876622; rs13087166; rs9831881; rs2087554; rs6805028; rs12489223; rs12495460; rs6798438; rs9868494; rs4856780; rs12485908; rs7622020; rs13094834; rs9881560; rs11915530; rs17046618; rs17046587; rs1576396; rs12639122; rs3952242; rs1122766; rs4579027; rs9812033; rs2087555; rs12488858; rs7426533; rs9875176; rs4132745; rs17194944; rs12486689; rs12171290; rs6779999; rs13076634; rs17194629; rs17046404; rs2634740; rs7620069; rs17046528; rs4450832; rs6781990; rs17046410; rs6765734; rs2634727; rs4577484; rs7637790; rs4455335; rs9824745; rs13317382; rs13067498; rs2363712; rs6548638; rs9828107; rs9637499; rs36050041; rs9874502; rs17807645; rs7624331; rs1831324; rs3892901; rs9851352; rs9866060; rs9815753; rs7616959; rs6797121; rs13323387; rs6548517; rs12494679; rs11916632; rs13314548; rs12496188; rs7645948; rs13316918; rs9817076; rs9681106; rs12632421; rs2772452; rs9820317; rs6778484; rs1888089; rs9854214; rs12486198; rs12639289; rs13083595; rs2290173; rs9832372; rs7651329; rs4453858; rs9869349; rs6785193; rs13075287; rs17046584; rs13317640; rs9879429; rs6787584; rs9309789; rs2247456; rs17046684; rs12485966; rs6789939; rs7625023; rs9836975; rs11923127; rs4615095; rs6779718; rs11715724; rs6788018; rs13076100; rs11924938; rs11719132; rs13077262; rs35494829; rs13315504; rs28602672; rs12492080; rs34855055; rs35782274; rs35581846; rs34217208; rs10619979; rs35233913; rs2122478; rs9879825; rs727946; rs34548059; rs34644474; rs34331206; rs5849773; rs9816554; rs35290770; rs6780879; rs11334599; rs11344481; rs13068996; rs935733; rs28555239; rs4856792; rs9860272; rs11719952; rs13069212; rs13085727; rs34364269; rs11382364; rs10709592; rs35627611; rs9884091; rs11293690; rs34478386; rs11716379; rs6776048; rs9857985; rs7652198; rs28367907; rs35729084; rs35232329; rs2044785; rs34070615; rs4610238; rs12639606; rs35527435; rs5849772; rs11544843; rs13091330; rs35895962; rs34204623; rs4241438; rs34101788; rs7433191; rs9867585; rs5849771; rs4583670; rs13318896; rs6786369; rs11544844; rs9861582; rs11293689; rs10664233; rs13081838; rs3927983; rs35084007; rs13086260; rs35245333; rs12492257; rs9809720; rs28735434; rs11415362; rs35798181; rs34665120; rs6784984; rs11286754; rs11289016; rs9868744; rs17046791; rs9309844; rs9834508; rs11329006; rs34328558; rs9869174; rs34015900; rs35326031; rs34840120; rs28555508; rs10706991; rs7638012; rs9830265; rs9757092; rs12107368; rs13100161; rs9879448; rs2772483; rs6783061; rs11425691; rs10675875; rs9867119; rs28515554; rs5849768; rs9637488; rs13059103; rs11296367; rs12495231; rs6794334; rs28667615; rs13081336; rs10599940; rs35987826; rs5849760; rs35031486; rs7649606; rs35096761; rs35825212; rs35498766; rs34003374; rs10632719; rs34530835; rs3217601; rs4328817; rs35733089; rs13088154; rs2772472; rs34120848; rs34223793; rs35721271; rs11385794; rs11341706; rs11425840; rs34358160; rs34609500; rs35100169; rs13065827; rs28497416; rs12107788; rs34971298; rs35199930; rs2772476; rs9873407; rs36108956; rs9875143; rs6807831; rs6548602; rs13095750; rs13100681; rs13098674; rs13082800; rs35493366; rs10713844; rs11434315; rs10049062; rs9867820; rs36083818; rs35254617; rs34568063; rs34107849; rs3030312; rs28449793; rs10619711; rs3949777; rs6788296; rs2087553; rs34360557; rs35913379; rs6773365; rs5849756; rs34973052; rs12233606; rs7653077; rs11709258; rs5849753; rs35652778; rs34830058; rs2772484; rs35015808; rs12152456; rs10711793; rs9846644; rs6797303; rs7638005; rs13069557; rs35931374; rs6548546; rs35014071; rs36010276; rs7641854; rs9883219; rs34831669; rs5849767; rs34428121; rs13066142; rs7652707; rs35739416; rs7626648; rs28815297; rs34179592; rs9836868; rs34140436; rs12374036; rs2772481; rs35453270; rs11439662; rs34043051; rs11305166; rs2634739; rs9832485; rs9713391; rs13065538; rs34483858; rs2363092; rs9828219; rs7614213; rs35369702; rs34355037; rs35794972; rs13085220; rs13069047; rs9840334; rs34235132; rs7616862; rs13098673; rs35921287; rs35206482; rs36054112; rs35995435; rs5849759; rs34737079; rs11336787; rs11925124; rs10711088; rs4488853; rs9833837; rs28534617; rs9814762; rs35256087; rs11313625; rs7632745; rs10704370; rs10702905; rs35119821; rs13099732; rs1985180; rs34385114; rs11923464; rs13069994; rs28631897; rs5849764; rs5849755; rs34305042; rs34703906; rs4021918; rs11336426; rs34517389; rs10575720; rs13084859; rs35520490; rs9859605; rs9682288; rs34893681; rs13067737; rs7633822; rs13095360; rs28420787; rs4271933; rs35106275; rs7635366; rs34027308; rs13092025; rs6787206; rs11368858; rs34389176; rs5849769; rs9682516; rs35082631; rs35397496; rs36013860; rs11412092; rs4289360; rs4856871; rs4856785; rs4258985; rs35007690; rs9815939; rs35823242; rs7625317; rs11337211; rs35957246; rs28501325; rs9821884; rs34588439; rs10703578; rs34088808; rs6548547; rs34371385; rs13061360; rs34900380; rs34438558; rs6767651; rs28626884; rs35629133; rs7631965; rs2634723; rs11319604; rs35223699; rs35413537; rs3030362; rs11453779; rs9865859; rs13088840; rs3030349; rs35337964; rs13319623; rs4455333; rs11718190; rs9867167; rs36088092; rs35286803; rs34212729; rs35183667; rs7612502; rs9819219; rs10620960; rs34732522; rs9815368; rs28637707; rs4856866; rs6785877; rs5849758; rs34750768; rs35595066; rs13091292; rs9847205; rs34264212; rs33937007; rs13060092; rs35768607; rs28483087; rs2634720; rs35265988; rs35026560; rs5849766; rs28727288; rs7639591; rs4426696; rs35077037; rs2772485; rs34979135; rs9874854; rs7428163; rs9853254; rs10670271; rs6784128; rs11348400; rs7616399; rs9942103; rs35103866; rs7647876; rs10576234; rs35765210; rs9821906; rs12107369; rs34666190; rs3038296; rs35761995; rs4527393; rs6779086; rs13092026; rs9757048; rs9836413; rs33988116; rs7617258; rs35118034; rs17046626; rs13074204; rs6771647; rs9840770; rs36047981; rs10576047; rs4856870; rs9823054; rs9871515; rs35535604; rs28579576; rs34547836; rs2772482; rs9867383; rs35332876; rs35157115; rs36040311; rs7631964; rs13085930; rs13059542; rs34598522; rs10584878; rs11293491; rs13322044; rs5849761; rs13090709; rs35584695; rs9680952; rs11358356; rs11127607; rs10568371; rs6784255; rs11283808; rs4856856; rs35291546; rs5849762; rs28706578; rs5849757; rs7647801; rs9831836; rs35874465; rs13074181; rs12233605; rs12107065; rs2634721; rs34860365; rs34228398; rs4856875; rs34795315; rs4856787; rs35311484; rs13090999; rs35624985; rs9880579; rs35514867; rs41356347; rs34544815; rs9820151; rs13083912; rs7632835; rs5028414; rs34736065; rs28688196; rs13079607; rs9871993; rs5849765; rs13090398; rs5849754; rs5024750; rs28729332; rs34788162; rs34173318; rs28669229; rs4856793; rs10613674; rs7620108; rs35261690; rs11127600; rs1120653; rs11719613; rs12492717; rs12634424; rs12637020; rs13069251; rs13070332; rs13076573; rs13076954; rs13076991; rs13091275; rs13091433; rs13099253; rs1490268; rs1490269; rs17046321; rs17046340; rs17046803; rs17806805; rs17806888; rs1979639; rs1979640; rs2130546; rs2130547; rs2363709; rs2363713; rs2363714; rs2885872; rs3952322; rs6548690; rs6806285; rs7615766; rs7620956; rs7639427; rs7647518; rs9832987; rs9833822; rs9860059; rs9864384

# Metabolic_Enzyme_6_General_References:
9765291

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5344

# Metabolic_Enzyme_7_Name:
Nucleoside diphosphate kinase B

# Metabolic_Enzyme_7_Synonyms:
NDK B; NDP kinase B; nm23-H2; C-myc purine-binding transcription factor PUF

# Metabolic_Enzyme_7_Gene_Name:
NME2

# Metabolic_Enzyme_7_Protein_Sequence:
>Nucleoside diphosphate kinase 
BMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRP
FFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHG
SDSVKSAEKEISLWFKPEELVDYKSCAHDWVYE

# Metabolic_Enzyme_7_Number_of_Residues:
152

# Metabolic_Enzyme_7_Molecular_Weight:
17298

# Metabolic_Enzyme_7_Theoretical_pI:
8.69

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  nucleoside diphosphate kinase activity
 ||
>>>
Process:  CTP biosynthesis
Process:  nucleoside triphosphate metabolism
Process:  nucleoside triphosphate biosynthesis
Process:  ribonucleoside triphosphate biosynthesis
Process:  pyrimidine ribonucleoside triphosphate biosynthesis
Process:  UTP biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside triphosphate biosynthesis
Process:  purine ribonucleoside triphosphate biosynthesis
Process:  GTP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Acts as a transcriptional activator of the c-Myc gene; binds DNA nonspecifically (Ref.3)

# Metabolic_Enzyme_7_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_7_Reaction:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00334:NDK

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.7.4.6

# Metabolic_Enzyme_7_GenBank_ID_Protein:
4467843

# Metabolic_Enzyme_7_SwissProt_ID:
NDKB_HUMAN (P22392)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
NME2

# Metabolic_Enzyme_7_Geneatlas_id:
NME2

# Metabolic_Enzyme_7_hgnc_id:
HGNC:7850

# Metabolic_Enzyme_7_PDB_ID:
1NSK

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm. Nucleus

# Metabolic_Enzyme_7_Gene_Sequence:
>459 bp
ATGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTG
GTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTC
CTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTACATTGACCTGAAAGACCGACCATTC
TTCCCTGGGCTGGTGAAGTACATGAACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGG
CTGAACGTGGTGAAGACAGGCCGAGTGATGCTTGGGGAGACCAATCCAGCAGATTCAAAG
CCAGGCACCATTCGTGGGGACTTCTGCATTCAGGTTGGCAGGAACATCATTCATGGCAGT
GATTCAGTAAAAAGTGCTGAAAAAGAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTT
GACTACAAGTCTTGTGCTCATGACTGGGTCTATGAATAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
X58965

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_7_Locus:
17q21.3

# Metabolic_Enzyme_7_SNPs:
Not Available

# Metabolic_Enzyme_7_General_References:
1851158; 1988104; 8392752; 7658474; 8747457

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5318

# Metabolic_Enzyme_8_Name:
Ectonucleoside triphosphate diphosphohydrolase 3

# Metabolic_Enzyme_8_Synonyms:
NTPDase 3; Ecto-ATP diphosphohydrolase; ATPDase; Ecto-apyrase; CD39 antigen-like 3; HB6

# Metabolic_Enzyme_8_Gene_Name:
ENTPD3

# Metabolic_Enzyme_8_Protein_Sequence:
>Ectonucleoside triphosphate diphosphohydrolase 3
MFTVLTRQPCEQAGLKALYRTPTIIALVVLLVSIVVLVSITVIQIHKQEVLPPGLKYGIV
LDAGSSRTTVYVYQWPAEKENNTGVVSQTFKCSVKGSGISSYGNNPQDVPRAFEECMQKV
KGQVPSHLHGSTPIHLGATAGMRLLRLQNETAANEVLESIQSYFKSQPFDFRGAQIISGQ
EEGVYGWITANYLMGNFLEKNLWHMWVHPHGVETTGALDLGGASTQISFVAGEKMDLNTS
DIMQVSLYGYVYTLYTHSFQCYGRNEAEKKFLAMLLQNSPTKNHLTNPCYPRDYSISFTM
GHVFDSLCTVDQRPESYNPNDVITFEGTGDPSLCKEKVASIFDFKACHDQETCSFDGVYQ
PKIKGPFVAFAGFYYTASALNLSGSFSLDTFNSSTWNFCSQNWSQLPLLLPKFDEVYARS
YCFSANYIYHLFVNGYKFTEETWPQIHFEKEVGNSSIAWSLGYMLSLTNQIPAESPLIRL
PIEPPVFVGTLAFFTAAALLCLAFLAYLCSATRRKRHSEHAFDHAVDSD

# Metabolic_Enzyme_8_Number_of_Residues:
529

# Metabolic_Enzyme_8_Molecular_Weight:
59106

# Metabolic_Enzyme_8_Theoretical_pI:
6.40

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
Has a threefold preference for the hydrolysis of ATP over ADP

# Metabolic_Enzyme_8_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_8_Reaction:
ATP + 2 H2O = AMP + 2 phosphate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF01150:GDA1_CD39

# Metabolic_Enzyme_8_Signals:
1-37

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.6.1.5

# Metabolic_Enzyme_8_GenBank_ID_Protein:
3335100

# Metabolic_Enzyme_8_SwissProt_ID:
ENTP3_HUMAN (O75355)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
ENTPD3

# Metabolic_Enzyme_8_Geneatlas_id:
ENTPD3

# Metabolic_Enzyme_8_hgnc_id:
HGNC:3365

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential)

# Metabolic_Enzyme_8_Gene_Sequence:
>1590 bp
ATGTTCACTGTGCTGACCCGCCAACCATGTGAGCAAGCAGGCCTCAAGGCCCTCTACCGA
ACTCCAACCATCATTGCCTTGGTGGTCTTGCTTGTGAGTATTGTGGTACTTGTGAGTATC
ACTGTCATCCAGATCCACAAGCAAGAGGTCCTCCCTCCAGGACTGAAGTATGGTATTGTG
CTGGATGCCGGGTCTTCAAGAACCACAGTCTACGTGTATCAATGGCCAGCAGAAAAAGAG
AATAATACCGGAGTGGTCAGTCAAACCTTCAAATGTAGTGTGAAAGGCTCTGGAATCTCC
AGCTATGGAAATAACCCCCAAGATGTCCCCAGAGCCTTTGAGGAGTGTATGCAAAAAGTC
AAGGGGCAGGTTCCATCCCACCTCCACGGATCCACCCCCATTCACCTGGGAGCCACGGCT
GGGATGCGCTTGCTGAGGTTGCAAAATGAAACAGCAGCTAATGAAGTCCTTGAAAGCATC
CAAAGCTACTTCAAGTCCCAGCCCTTTGACTTTAGGGGTGCTCAAATCATTTCTGGGCAA
GAAGAAGGGGTATATGGATGGATTACAGCCAACTATTTAATGGGAAATTTCCTGGAGAAG
AACCTGTGGCACATGTGGGTGCACCCGCATGGAGTGGAAACCACGGGTGCCCTGGACTTA
GGTGGTGCCTCCACCCAAATATCCTTCGTGGCAGGAGAGAAGATGGATCTGAACACCAGC
GACATCATGCAGGTGTCCCTGTATGGCTACGTATACACGCTCTACACACACAGCTTCCAG
TGCTATGGCCGGAATGAGGCTGAGAAGAAGTTTCTGGCAATGCTCCTGCAGAATTCTCCT
ACCAAAAACCATCTCACCAATCCCTGTTACCCTCGGGATTATAGCATCAGCTTCACCATG
GGCCATGTATTTGATAGCCTGTGCACTGTGGACCAGAGGCCAGAAAGTTATAACCCCAAT
GATGTCATCACTTTTGAAGGAACTGGGGACCCATCTCTGTGTAAGGAGAAGGTGGCTTCC
ATATTTGACTTCAAAGCTTGCCATGATCAAGAAACCTGTTCTTTTGATGGGGTTTATCAG
CCAAAGATTAAAGGGCCATTTGTGGCTTTTGCAGGATTCTACTACACAGCCAGTGCTTTA
AATCTTTCAGGTAGCTTTTCCCTGGACACCTTCAACTCCAGCACCTGGAATTTCTGCTCA
CAGAATTGGAGTCAGCTCCCACTGCTGCTCCCCAAATTTGATGAGGTATATGCCCGCTCT
TACTGCTTCTCAGCCAACTACATCTACCACTTGTTTGTGAACGGTTACAAATTCACAGAG
GAGACTTGGCCCCAAATACACTTTGAAAAAGAAGTGGGGAATAGCAGCATAGCCTGGTCT
CTTGGCTACATGCTCAGCCTGACCAACCAGATCCCAGCTGAAAGCCCTCTGATCCGTCTG
CCCATAGAACCACCTGTCTTTGTGGGCACCCTCGCTTTCTTCACAGTGGCAGCCTTGCTG
TGTCTGGCATTTCTTGCATACCTGTGTTCAGCAACCAGAAGAAAGAGGCACTCCGAGCAT
GCCTTTGACCATGCAGTGGATTCTGACTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
AF039917

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_8_Locus:
3p21.3

# Metabolic_Enzyme_8_SNPs:
rs1047855; rs2305521; rs9858868; rs11714871; rs17078798; rs2305522; rs12493020; rs897117; rs1466236; rs6599101; rs6808095; rs9332450; rs6599102; rs954589; rs6783755; rs9848083; rs951560; rs7645864; rs7636719; rs4973999; rs9829800; rs4973997; rs4973898; rs7648952; rs12490249; rs13324109; rs17079011; rs9849348; rs9873394; rs17078941; rs17078813; rs1466237; rs7634375; rs1105745; rs7631893; rs9822909; rs9859026; rs1466238; rs7625736; rs4283549; rs17078812; rs9857824; rs6793596; rs11707673; rs11714032; rs11720360; rs6599100; rs9875245; rs2371185; rs6804157; rs17078914; rs11921197; rs17078916; rs12492035; rs4973994; rs17078921; rs4973989; rs17078959; rs13099333; rs1037516; rs12490275; rs3774805; rs4973998; rs12492777; rs6796122; rs4973993; rs13326389; rs13321169; rs12491944; rs12634013; rs13081891; rs11920596; rs9848049; rs13066971; rs12636697; rs6807397; rs9864380; rs34266806; rs4470483; rs17852714; rs3733167; rs41286046; rs35071108; rs6773917; rs10671439; rs35839072; rs35836679; rs9874499; rs10551054; rs13073943; rs10565031; rs13094752; rs10620040; rs11351492; rs34255517; rs34665572; rs3774806; rs10575365; rs5848563; rs951561; rs13082239; rs3064608; rs11445995; rs9809377; rs35636349; rs35489659; rs4560275; rs6798459; rs10620057; rs13316488; rs13082375; rs6797651; rs6795906; rs13073946; rs3064609; rs41286044; rs35641310; rs35870509; rs13082222; rs13090979; rs9836330; rs34726619; rs28465354; rs10650731; rs9883218; rs9863737; rs9829324; rs1105746; rs5848564; rs9833430; rs9880286; rs9864423; rs3774807; rs28621801; rs34065066; rs6767610; rs11415995; rs3064615; rs35700770; rs5848565; rs9882941; rs34145192; rs34654655; rs10658778; rs11360523; rs9843979; rs36074810; rs9843965; rs13072002; rs35267876; rs41286048; rs9860002; rs9863679; rs13433935; rs35860386; rs9882954; rs11371152; rs9809378; rs28671141; rs28508335; rs34934417; rs6808552; rs10594515; rs9828299; rs1119179; rs12488805; rs12492578; rs12494022; rs2371184; rs6762997; rs6795066; rs7610586; rs7616273; rs7642552; rs9813231; rs9817233; rs9822644; rs9835219; rs9841335; rs9846606; rs9871825; rs9874006; rs9882464

# Metabolic_Enzyme_8_General_References:
9676430; 9675246; 10231536; 11300774

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5338

# Metabolic_Enzyme_9_Name:
Nucleoside diphosphate kinase, mitochondrial precursor

# Metabolic_Enzyme_9_Synonyms:
NDP kinase, mitochondrial; NDK; nm23-H4; Nucleoside diphosphate kinase D; NDPKD

# Metabolic_Enzyme_9_Gene_Name:
NME4

# Metabolic_Enzyme_9_Protein_Sequence:
>Nucleoside diphosphate kinase, mitochondrial precursor
MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGPSWTRERTLVAVKPDGVQRRLVGDVIQR
FERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRAS
RAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQ
HSSIHPA

# Metabolic_Enzyme_9_Number_of_Residues:
187

# Metabolic_Enzyme_9_Molecular_Weight:
20659

# Metabolic_Enzyme_9_Theoretical_pI:
10.75

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  nucleoside diphosphate kinase activity
 ||
>>>
Process:  CTP biosynthesis
Process:  nucleoside triphosphate metabolism
Process:  nucleoside triphosphate biosynthesis
Process:  ribonucleoside triphosphate biosynthesis
Process:  pyrimidine ribonucleoside triphosphate biosynthesis
Process:  UTP biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside triphosphate biosynthesis
Process:  purine ribonucleoside triphosphate biosynthesis
Process:  GTP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
Major role in the synthesis of nucleoside triphosphates other than ATP

# Metabolic_Enzyme_9_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_9_Reaction:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00334:NDK

# Metabolic_Enzyme_9_Signals:
1-15

# Metabolic_Enzyme_9_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.7.4.6

# Metabolic_Enzyme_9_GenBank_ID_Protein:
1945762

# Metabolic_Enzyme_9_SwissProt_ID:
NDKM_HUMAN (O00746)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
NME4

# Metabolic_Enzyme_9_Geneatlas_id:
NME4

# Metabolic_Enzyme_9_hgnc_id:
HGNC:7852

# Metabolic_Enzyme_9_PDB_ID:
1EHW

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Mitochondrion; mitochondrial intermembrane space

# Metabolic_Enzyme_9_Gene_Sequence:
>564 bp
ATGGGCGGCCTCTTCTGGCGCTCCGCGCTGCGGGGGCTGCGCTGCGGCCCGCGGGCCCCG
GGCCCGAGCCTGCTAGTGCGCCACGGCTCGGGAGGGCCCTCCTGGACCCGGGAGCGGACC
CTGGTGGCGGTGAAGCCCGATGGCGTGCAACGGCGGCTCGTTGGGGACGTGATCCAGCGC
TTTGAGAGGCGGGGCTTCACGCTGGTGGGGATGAAGATGCTGCAGGCACCAGAGAGCGTC
CTTGCCGAGCACTACCAGGACCTGCGGAGGAAGCCCTTCTACCCTGCCCTCATCCGCTAC
ATGAGCTCTGGGCCTGTGGTGGCCATGGTCTGGGAAGGGTACAATGTCGTCCGCGCCTCA
AGGGCCATGATTGGACACACCGACTCGGCTGAGGCTGCCCCAGGAACCATAAGGGGTGAC
TTCAGCGTCCACATCAGCAGGAATGTCATCCACGCCAGCGACTCCGTGGAGGGGGCCCAG
CGGGAGATCCAGCTGTGGTTCCAGAGCAGTGAGCTGGTGAGCTGGGCAGACGGGGGCCAG
CACAGCAGCATCCACCCAGCCTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
Y07604

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_9_Locus:
16p13.3

# Metabolic_Enzyme_9_SNPs:
rs14293; rs431324; rs763151; rs7185254; rs11248932; rs2071914; rs2363759; rs4984873; rs4984872; rs4984871; rs4984666; rs7188541; rs4399536; rs35267685; rs28676738; rs387290; rs7190051; rs7189866; rs35306680; rs2885894; rs9923794; rs28694736; rs11648458; rs11863625; rs12448825; rs2007351; rs3743890; rs3743894; rs3785290; rs379387; rs3809662; rs3826231; rs3826236; rs390499; rs407983; rs419012; rs436075; rs448063; rs5841; rs734798; rs873477; rs877904; rs8967

# Metabolic_Enzyme_9_General_References:
9099850; 11157797; 10799505

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5447

# Metabolic_Enzyme_10_Name:
Hexokinase-1

# Metabolic_Enzyme_10_Synonyms:
Hexokinase type I; HK I; Brain form hexokinase

# Metabolic_Enzyme_10_Gene_Name:
HK1

# Metabolic_Enzyme_10_Protein_Sequence:
>Hexokinase1
MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT
VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH
GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV
EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME
ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM
YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG
VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH
PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT
KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV
LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF
TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG
TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD
IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG
IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA
VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG
AALITAVGVRLRTEASS

# Metabolic_Enzyme_10_Number_of_Residues:
917

# Metabolic_Enzyme_10_Molecular_Weight:
102487

# Metabolic_Enzyme_10_Theoretical_pI:
6.78

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Not Available

# Metabolic_Enzyme_10_Specific_Function:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_10_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism;
 map00521  Streptomycin biosynthesis;
 map00530  Aminosugars metabolism

# Metabolic_Enzyme_10_Reaction:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00349:Hexokinase_1;
PF03727:Hexokinase_2

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.7.1.1

# Metabolic_Enzyme_10_GenBank_ID_Protein:
184021

# Metabolic_Enzyme_10_SwissProt_ID:
HXK1_HUMAN (P19367)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
HK1

# Metabolic_Enzyme_10_Geneatlas_id:
HK1

# Metabolic_Enzyme_10_hgnc_id:
HGNC:4922

# Metabolic_Enzyme_10_PDB_ID:
1HKB

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding

# Metabolic_Enzyme_10_Gene_Sequence:
>2754 bp
ATGATCGCCGCGCAGCTCCTGGCCTATTACTTCACGGAGCTGAAGGATGACCAGGTCAAA
AAGATTGACAAGTATCTGTATGCCATGCGGCTCTCCGATGAAACTCTCATAGATATCATG
ACTCGCTTCAGGAAGGAGATGAAGAATGGCCTCTCCCGGGATTTTAATCCAACAGCCACA
GTCAAGATGTTGCCAACATTCGTAAGGTCCATTCCTGATGGCTCTGAAAAGGGAGATTTC
ATTGCCCTGGATCTTGGTGGGTCTTCCTTTCGAATTCTGCGGGTGCAAGTGAATCATGAG
AAAAACCAGAATGTTCACATGGAGTCCGAGGTTTATGACACCCCAGAGAACATCGTGCAC
GGCAGTGGAAGCCAGCTTTTTGATCATGTTGCTGAGTGCCTGGGAGATTTCATGGAGAAA
AGGAAGATCAAGGACAAGAAGTTACCTGTGGGATTCACGTTTTCTTTTCCTTGCCAACAA
TCCAAAATAGATGAGGCCATCCTGATCACCTGGACAAAGCGATTTAAAGCGAGCGGAGTG
GAAGGAGCAGATGTGGTCAAACTGCTTAACAAAGCCATCAAAAAGCGAGGGGACTATGAT
GCCAACATCGTAGCTGTGGTGAATGACACAGTGGGCACCATGATGACCTGTGGCTATGAC
GACCAGCACTGTGAAGTCGGCCTGATCATCGGCACTGGCACCAATGCTTGCTACATGGAG
GAACTGAGGCACATTGATCTGGTGGAAGGAGACGAGGGGAGGATGTGTATCAATACAGAA
TGGGGAGCCTTTGGAGACGATGGATCATTAGAAGACATCCGGACAGAGTTTGACAGGGAG
ATAGACCGGGGATCCCTCAACCCTGGAAAACAGCTGTTTGAGAAGATGGTCAGTGGCATG
TACTTGGGAGAGCTGGTTCGACTGATCCTAGTCAAGATGGCCAAGGAGGGCCTCTTATTT
GAAGGGCGGATCACCCCGGAGCTGCTCACCCGAGGGAAGTTTAACACCAGTGATGTGTCA
GCCATCGAAAAGAATAAGGAAGGCCTCCACAATGCCAAAGAAATCCTGACCCGCCTGGGA
GTGGAGCCGTCCGATGATGACTGTGTCTCAGTCCAGCACGTTTGCACCATTGTCTCATTT
CGCTCAGCCAACTTGGTGGCTGCCACACTGGGCGCCATCTTGAACCGCCTGCGTGATAAC
AAGGGCACACCCAGGCTGCGGACCACGGTTGGTGTCGACGGATCTCTTTACAAGACGCAC
CCACAGTATTCCCGGCGTTTCCACAAGACTCTAAGGCGCTTGGTGCCAGACTCCGATGTG
CGCTTCCTCCTCTCGGAGAGTGGCAGCGGCAAGGGGGCTGCCATGGTGACGGCGGTGGCC
TACCGCTTGGCCGAGCAGCACCGGCAGATAGAGGAGACCCTGGCTCATTTCCACCTCACC
AAAGACATGCTGCTGGAGGTGAAGAAGAGGATGCGGGCCGAGATGGAGCTGGGGCTGAGG
AAGCAGACGCACAACAATGCCGTGGTTAAGATGCTGCCCTCCTTCGTCCGGAGAACTCCC
GACGGGACCGAGAATGGTGACTTCTTGGCCCTGGATCTTGGAGGAACCAATTTCCGTGTG
CTGCTGGTGAAAATCCGTAGTGGGAAAAAGAGAACGGTGGAAATGCACAACAAGATCTAC
GCCATTCCTATTGAAATCATGCAGGGCACTGGGGAAGAGCTGTTTGATCACATTGTCTCC
TGCATCTCTGACTTCTTGGACTACATGGGGATCAAAGGCCCCAGGATGCCTCTGGGCTTC
ACGTTCTCATTTCCCTGCCAGCAGACGAGTCTGGACGCGGGAATCTTGATCACGTGGACA
AAGGGTTTTAAGGCAACAGACTGCGTGGGCCACGATGTAGTCACCTTACTAAGGGATGCG
ATAAAAAGGAGAGAGGAATTTGACCTGGACGTGGTGGCTGTGGTCAACGACACAGTGGGC
ACCATGATGACCTGTGCTTATGAGGAGCCCACCTGTGAGGTTGGACTCATTGTTGGGACC
GGCAGCAATGCCTGCTACATGGAGGAGATGAAGAACGTGGAGATGGTGGAGGGGGACCAG
GGGCAGATGTGCATCAACATGGAGTGGGGGGCCTTTGGGGACAACGGGTGTCTGGATGAT
ATCAGGACACACTACGACAGACTGGTGAACGAATATTCCCTAAATGCTGGGAAACAAAGG
TATGAGAAGATGATCAGTGGTATGTACCTGGGTGAAATCGTCCGCAACATCTTAATCGAC
TTCACCAAGAAGGGATTCCTCTTCCGAGGGCAGATCTCTGAGACGATGAAGACCCGGGGC
ATCTTTGAGACCAAGTTTCTCTCTCAGATCGAGAGTGACCGATTAGCACTGCTCCAGGTC
CGGGCTATCCTCCAGCAGCTAGGTCTGAATAGCACCTGCGATGACAGTATCCTCGTCAAG
ACAGTGTGCGGGGTGGTGTCCAGGAGGGCCGCACAGCTGTGTGGCGCAGGCATGGCTGCG
GTTGTGGATAAGATCCGCGAGAACAGAGGACTGGACCGTCTGAATGTGACTGTGGGAGTG
GACGGGACACTCTACAAGCTTCATCCACACTTCTCCAGAATCATGCACCAGACGGTGAAG
GAACTGTCACCAAAATGTAACGTGTCCTTCCTCCTGTCTGAGGATGGCAGCGGCAAGGGG
GCCGCCCTCATCACGGCCGTGGGCGTGCGGTTACGCACAGAGGCAAGCAGCTAA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
M75126

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_10_Locus:
10q22

# Metabolic_Enzyme_10_SNPs:
rs906220; rs1054203; rs748235; rs12254258; rs1133189; rs10998760; rs34616021; rs14006; rs2394539; rs10998704; rs6480394; rs10762281; rs3812689; rs10998703; rs4746834; rs7893994; rs4469773; rs7914134; rs1472817; rs2894081; rs11815833; rs2394540; rs10823332; rs10762280; rs10762277; rs2394543; rs7897621; rs4746837; rs7068435; rs13139; rs1876257; rs5030916; rs10998700; rs11819086; rs12257270; rs2394545; rs11818777; rs10998699; rs10762275; rs7907176; rs7903625; rs12216; rs10998702; rs1472819; rs2394541; rs7095428; rs1472816; rs2394538; rs10823333; rs10998692; rs11813648; rs11818779; rs10762276; rs10823329; rs12242964; rs12242332; rs10762273; rs1472818; rs11818927; rs10998684; rs2394535; rs11815263; rs7095547; rs10823328; rs10823335; rs12751; rs10823331; rs10998694; rs11815943; rs11815513; rs4746833; rs12244771; rs10762278; rs10823334; rs2894080; rs11818799; rs5030886; rs2394537; rs2089356; rs10998696; rs10998689; rs11819674; rs10762279; rs7092374; rs10823330; rs2002905; rs12263326; rs4372334; rs10998691; rs11816714; rs12265826; rs4746836; rs10740318; rs7095424; rs12218331; rs7907242; rs5030949; rs11816128; rs7095579; rs12241382; rs1867972; rs2084274; rs1867971; rs906215; rs1867975; rs749108; rs2305198; rs4537657; rs7084213; rs11596193; rs7909192; rs2305196; rs1227938; rs7072268; rs10823348; rs10159541; rs7094651; rs7084363; rs1900466; rs12414591; rs10762288; rs10733851; rs7921170; rs7921060; rs7095140; rs749107; rs10762282; rs2015803; rs6480396; rs6480404; rs1867973; rs3812691; rs10998738; rs11595647; rs11812791; rs10823360; rs9664217; rs4745988; rs10823350; rs10159477; rs10823357; rs12243794; rs4746848; rs10998730; rs7097078; rs749105; rs7071731; rs4745987; rs16926253; rs7076563; rs3793846; rs10998725; rs2305197; rs4072508; rs7898060; rs11597346; rs6480400; rs11596110; rs7092155; rs2394560; rs4745981; rs4589168; rs11595655; rs10823343; rs3829185; rs11599680; rs10823354; rs6480403; rs12262904; rs10998751; rs4746838; rs10823349; rs11819564; rs10762292; rs1867974; rs906216; rs2278745; rs10998754; rs10823356; rs10159540; rs11818709; rs4746839; rs7079157; rs7088667; rs7094214; rs11599150; rs4746846; rs11598389; rs1900467; rs10823345; rs12265560; rs10762290; rs2394561; rs10823355; rs10823340; rs12244847; rs2305199; rs4746841; rs749106; rs7913579; rs7076745; rs3793845; rs10823341; rs11596587; rs11596868; rs10998720; rs7905437; rs7917338; rs6480402; rs7914033; rs16926244; rs3829183; rs7067927; rs7912524; rs12416320; rs16926252; rs12571072; rs4746849; rs11596199; rs10823339; rs10998728; rs6480398; rs10823342; rs11813750; rs12415409; rs10998739; rs10762284; rs10998742; rs10823353; rs10998741; rs10128334; rs7895704; rs7902303; rs4745982; rs11818471; rs10159490; rs4746847; rs10128330; rs10762285; rs5030915; rs10998719; rs12252483; rs7072349; rs6480399; rs4745986; rs10998752; rs10998710; rs7905515; rs3793847; rs7904932; rs17489768; rs12255367; rs10998747; rs34895304; rs12240847; rs10823358; rs17567544; rs906221; rs12251732; rs10823338; rs10823351; rs9299503; rs10998726; rs10998735; rs12253797; rs10998706; rs7067730; rs12248026; rs12243312; rs12262357; rs4471325; rs11599654; rs12252916; rs3793844; rs7081302; rs10998715; rs12262687; rs16926246; rs7905243; rs10823352; rs10823337; rs10762286; rs10823359; rs10128513; rs10998748; rs17476364; rs10159599; rs11597225; rs10823344; rs10998736; rs7902486; rs12220752; rs7094943; rs7920991; rs10998731; rs16926242; rs10998723; rs12254195; rs10762293; rs4746851; rs7899625; rs16926292; rs10159598; rs2135589; rs10823347; rs4364944; rs7077298; rs10998716; rs16926249; rs11599655; rs12243716; rs7097551; rs10998744; rs10762283; rs12771121; rs7083032; rs12411628; rs10762287; rs10762291; rs7913272; rs12355201; rs5030917; rs10998733; rs10998740; rs1108272; rs4746850; rs11819352; rs10823346; rs12778692; rs6480397; rs11593167; rs11816511; rs11812380; rs10998724; rs2394534; rs1054202; rs34410083; rs35378602; rs41279658; rs12356717; rs35387972; rs12243655; rs35468118; rs1803712; rs10998693; rs35379025; rs5785909; rs35517819; rs35080013; rs34434447; rs10998687; rs28558590; rs12357729; rs12219469; rs12780875; rs34997376; rs35104096; rs12780655; rs10762274; rs34150929; rs12263929; rs10998698; rs10998690; rs10716029; rs2394542; rs12221426; rs4282890; rs12569892; rs7916281; rs35143457; rs2394536; rs36020756; rs3086615; rs7083056; rs10998695; rs1810023; rs2063048; rs36007468; rs10998688; rs11286202; rs35585147; rs28422950; rs35431404; rs12242466; rs35264480; rs35699014; rs14382; rs34382339; rs34539856; rs5785910; rs4745980; rs4638197; rs5785908; rs34031234; rs12262447; rs11815616; rs34736420; rs10672043; rs35376303; rs34164890; rs12253706; rs7914285; rs4622145; rs34547808; rs11556966; rs34453032; rs10998685; rs12241639; rs10998686; rs10998701; rs10998697; rs10400052; rs12268098; rs11819094; rs35607669; rs7905200; rs2394544; rs3750793; rs35895463; rs7083200; rs12220458; rs7914344; rs12259682; rs12571243; rs7894213; rs34610927; rs12253579; rs35804876; rs41279664; rs5030950; rs34938278; rs12242474; rs34931035; rs12780492; rs35306200; rs34327925; rs1057566; rs11819447; rs10668853; rs4453112; rs41279662; rs12252651; rs10998745; rs36104030; rs12247331; rs33984080; rs4366384; rs35347843; rs35619781; rs11592707; rs34834335; rs891564; rs34694521; rs35135619; rs5785912; rs34040090; rs35627580; rs10578071; rs6143971; rs1867970; rs12780794; rs10998734; rs11816980; rs35368978; rs10998714; rs11597178; rs34605664; rs10998756; rs7478446; rs34064357; rs11497990; rs10688656; rs7911813; rs7476246; rs12254694; rs34142395; rs35932296; rs1867976; rs12252489; rs35684348; rs35802626; rs36006142; rs35233497; rs10998757; rs16926233; rs10998709; rs10998722; rs12240898; rs34164799; rs34068824; rs41435648; rs35975244; rs34124986; rs35131910; rs11819725; rs11424399; rs906223; rs7476298; rs35300718; rs10998729; rs36006221; rs5785913; rs11597418; rs34156889; rs11592659; rs10679551; rs10159538; rs10998755; rs35790367; rs36124339; rs5030919; rs16926269; rs41279656; rs12264809; rs35680310; rs11596222; rs34391428; rs36012744; rs34821837; rs10580275; rs10998718; rs12769898; rs7090983; rs34729523; rs35983460; rs11598601; rs34428846; rs11597672; rs35532806; rs10998708; rs35337416; rs2089357; rs3086649; rs10998746; rs10684489; rs5019350; rs12248865; rs35385375; rs35827992; rs11400433; rs10128509; rs35246952; rs35351562; rs33920450; rs10998707; rs35258842; rs10998737; rs16926245; rs34348007; rs12765788; rs12248628; rs7911786; rs10998743; rs17489948; rs34969484; rs6480401; rs12258259; rs34967951; rs11591962; rs41279660; rs35833065; rs10998759; rs3086686; rs12782422; rs10998711; rs35024696; rs34137364; rs33920304; rs35326884; rs34301815; rs35860582; rs906222; rs35929312; rs7093863; rs11389885; rs10998705; rs3812690; rs7081298; rs2894082; rs12360012; rs34309168; rs12769387; rs41279654; rs36096331; rs34767311; rs36022169; rs12247649; rs10542467; rs12770156; rs12259309; rs12245854; rs35510140; rs10998750; rs12357558; rs34815317; rs35215102; rs3956966; rs35733293; rs12765993; rs4745983; rs11295023; rs5019351; rs10998753; rs10998727; rs12769386; rs11421011; rs12243746; rs34133918; rs12356440; rs34966318; rs35451830; rs7094375; rs12359036; rs12763363; rs34977762; rs10047284; rs10998758; rs12098572; rs35694546; rs10603617; rs10531274; rs35035641; rs10998717; rs11593738; rs12257925; rs5030918; rs34367822; rs35534322; rs4745984; rs7072757; rs12243670; rs7088597; rs11267589; rs12411524; rs35376932; rs34620768; rs10823336; rs11597926; rs10998712; rs28510843; rs10536437; rs35922004; rs12263320; rs35828572; rs12246003; rs7094252; rs6480405; rs10998749; rs10159790; rs35341389; rs10998713; rs12264596; rs2278744; rs34085490; rs4746840; rs34767665; rs10998732; rs35490740; rs35026222; rs34941976; rs34818501; rs12264010; rs34125846; rs10998682; rs34564828; rs34015903; rs34747241; rs1000251; rs10740320; rs10998677; rs10998679; rs10998762; rs11813340; rs11815413; rs11817458; rs12244723; rs1227958; rs12776509; rs12781552; rs1549797; rs1549798; rs1549799; rs16926201; rs2278746; rs2611; rs34690134; rs35008643; rs3740601; rs3793849; rs3793850; rs3793851; rs4603200; rs4644560; rs4746832; rs6480393; rs7097827; rs7097971; rs7098065; rs906219; rs986525

# Metabolic_Enzyme_10_General_References:
3207429; 9531504; 1637300; 1985912; 9028305; 10978502; 8706938; 9493266; 9735292; 10574795; 10686099; 7655856

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
6039

# Metabolic_Enzyme_11_Name:
Pyruvate kinase isozymes M1/M2

# Metabolic_Enzyme_11_Synonyms:
Pyruvate kinase muscle isozyme; Pyruvate kinase 2/3; Cytosolic thyroid hormone-binding protein; CTHBP; THBP1

# Metabolic_Enzyme_11_Gene_Name:
PKM2

# Metabolic_Enzyme_11_Protein_Sequence:
>Pyruvate kinase isozymes M1/M2
MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEAS
FKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP

# Metabolic_Enzyme_11_Number_of_Residues:
531

# Metabolic_Enzyme_11_Molecular_Weight:
57938

# Metabolic_Enzyme_11_Theoretical_pI:
7.94

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  pyruvate kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
ATP + pyruvate = ADP + phosphoenolpyruvate

# Metabolic_Enzyme_11_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00230  Purine metabolism;
 map00620  Pyruvate metabolism;
 map00710  Carbon fixation

# Metabolic_Enzyme_11_Reaction:
ATP + pyruvate = ADP + phosphoenolpyruvate

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00224:PK;
PF02887:PK_C

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.7.1.40

# Metabolic_Enzyme_11_GenBank_ID_Protein:
189998

# Metabolic_Enzyme_11_SwissProt_ID:
KPYM_HUMAN (P14618)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
PKM2

# Metabolic_Enzyme_11_Geneatlas_id:
PKM2

# Metabolic_Enzyme_11_hgnc_id:
HGNC:9021

# Metabolic_Enzyme_11_PDB_ID:
1F3X

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Not Available

# Metabolic_Enzyme_11_Gene_Sequence:
>1596 bp
ATGTCGAAGCCCCATAGTGAAGCCGGGACTGCCTTCATTCAGACCCAGCAGCTGCACGCA
GCCATGGCTGACACATTCCTGGAGCACATGTGCCGCCTGGACATTGATTCACCACCCATC
ACAGCCCGGAACACTGGCATCATCTGTACCATTGGCCCAGCTTCCCGATCAGTGGAGACG
TTGAAGGAGATGATTAAGTCTGGAATGAATGTGGCTCGTCTGAACTTCTCTCATGGAACT
CATGAGTACCATGCGGAGACCATCAAGAATGTGCGCACAGCCACGGAAAGCTTTGCTTCT
GACCCCATCCTCTACCGGCCCGTTGCTGTGGCTCTAGACACTAAAGGACCTGAGATCCGA
ACTGGGCTCATCAAGGGCAGCGGCACTGCAGAGGTGGAGCTGAAGAAGGGAGCCACTCTC
AAAATCACGCTGGATAACGCCTACATGGAAAAGTGTGACGAGAACATCCTGTGGCTGGAC
TACAAGAACATCTGCAAGGTGGTGGAAGTGGGCAGCAAGATCTACGTGGATGATGGGCTT
ATTTCTCTCCAGGTGAAGCAGAAAGGTGCCGACTTCCTGGTGACGGAGGTGGAAAATGGT
GGCTCCTTGGGCAGCAAGAAGGGTGTGAACCTTCCTGGGGCTGCTGTGGACTTGCCTGCT
GTGTCGGAGAAGGACATCCAGGATCTGAAGTTTGGGGTCGAGCAGGATGTTGATATGGTG
TTTGCGTCATTCATCCGCAAGGCATCTGATGTCCATGAAGTTAGGAAGGTCCTGGGAGAG
AAGGGAAAGAACATCAAGATTATCAGCAAAATCGAGAATCATGAGGGGGTTCGGAGGTTT
GATGAAATCCTGGAGGCCAGTGATGGGATCATGGTGGCTCGTGGTGATCTAGGCATTGAG
ATTCCTGCAGAGAAGGTCTTCCTTGCTCAGAAGATGATGATTGGACGGTGCAACCGAGCT
GGGAAGCCTGTCATCTGTGCTACTCAGATGCTGGAGAGCATGATCAAGAAGCCCCGCCCC
ACTCGGGCTGAAGGCAGTGATGTGGCCAATGCAGTCCTGGATGGAGCCGACTGCATCATG
CTGTCTGGAGAAACAGCCAAAGGGGACTATCCTCTGGAGGCTGTGCGCATGCAGAACCTG
ATTGCCCGTGAGGCAGAGGCTGCCATCTACCACTTGCAATTATTTGAGGAACTCCGCCGC
CTGGCGCCCATTACCAGCGACCCCACAGAAGCCACCGCCGTGGGTGCCGTGGAGGCCTCC
TTCAAGTGCTGCAGTGGGGCCATAATCGTCCTCACCAAGTCTGGCAGGTCTGCTCACCAG
GTGGCCAGATACCGCCCACGTGCCCCCATCATTGCTGTGACCCGGAATCCCCAGACAGCT
CGTCAGGCCCACCTGTACCGTGGCATCTTCCCTGTGCTGTGCAAGGACCCAGTCCAGGAG
GCCTGGGCTGAGGACGTGGACCTCCGGGTGAACTTTGCCATGAATGTTGGCAAGGCCCGA
GGCTTCTTCAAGAAGGGAGATGTGGTCATTGTGCTGACCGGATGGCGCCCTGGCTCCGGC
TTCACCAACACCATGCGTGTTGTTCCTGTGCCGTGA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
M23725

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_11_Locus:
15q22

# Metabolic_Enzyme_11_SNPs:
rs10514; rs3759901; rs1037680; rs890312; rs2052713; rs6494994; rs6494995; rs8192386; rs8192381; rs8192362; rs8192385; rs8192364; rs8192357; rs7179427; rs8192363; rs8192392; rs8192356; rs4611402; rs8192365; rs8192355; rs12441553; rs8192350; rs8192354; rs8192353; rs8192359; rs8192379; rs2959906; rs8192387; rs8192374; rs8192378; rs8192360; rs8192367; rs8192417; rs4506844; rs8033167; rs3825868; rs8192420; rs8192418; rs2607090; rs2856929; rs8192393; rs3825949; rs8040828; rs8031386; rs8192419; rs8192401; rs11631216; rs8192396; rs8192400; rs6494993; rs8192422; rs8192402; rs8192425; rs12591361; rs8192397; rs3803471; rs8023703; rs8192431; rs2959908; rs4777493; rs8192394; rs916133; rs8192413; rs8192399; rs12594297; rs8192404; rs8192412; rs8192395; rs8192408; rs8192343; rs3743229; rs3743228; rs8192349; rs3743227; rs8192347; rs8192346; rs3759902; rs11558360; rs11558350; rs11558353; rs11558354; rs2959910; rs11558375; rs11558352; rs11558357; rs11558370; rs17853396; rs11558365; rs11558371; rs11558368; rs8192411; rs11558359; rs11558378; rs8192407; rs11558376; rs11558356; rs11558367; rs3021075; rs8192366; rs8192389; rs35255865; rs12900318; rs8192351; rs35494718; rs1065654; rs28375199; rs8192368; rs8192372; rs35843341; rs8192358; rs34912901; rs8192371; rs28675719; rs34934268; rs10732234; rs7179691; rs10706808; rs11857075; rs8192376; rs11432818; rs8192369; rs2959907; rs8192370; rs2124857; rs35603965; rs3743225; rs8192375; rs8192384; rs12900042; rs12442597; rs8192382; rs1065655; rs36067769; rs35563486; rs8192361; rs8192390; rs11419360; rs34333350; rs8192373; rs8192388; rs8192383; rs8192352; rs34876633; rs34029406; rs2925649; rs8192380; rs3202686; rs8192377; rs8192391; rs41277722; rs34293190; rs10616881; rs8192403; rs2445734; rs10152494; rs12437619; rs8192409; rs8192414; rs8192405; rs28564216; rs7170259; rs35057170; rs12906366; rs2607088; rs34453402; rs12906365; rs2607089; rs2856932; rs35024842; rs12905751; rs12595329; rs11546423; rs8192415; rs2445733; rs2856934; rs35943695; rs8192406; rs8192430; rs12916226; rs8192429; rs2856928; rs2001035; rs34810448; rs8192410; rs34388767; rs28658414; rs12909527; rs2856926; rs2001034; rs8192424; rs8192426; rs2607091; rs34379240; rs762804; rs8192416; rs2607085; rs8043345; rs2445732; rs35783339; rs8192428; rs2856930; rs8028169; rs2001033; rs28493222; rs2856927; rs2607092; rs8192423; rs12438957; rs34765962; rs12905909; rs2445735; rs2856933; rs2607086; rs12905910; rs34787795; rs35471277; rs35278688; rs2607093; rs2607087; rs34454887; rs11356526; rs8028636; rs8192398; rs12906394; rs8192427; rs8192421; rs8023910; rs2607084; rs8192345; rs35618475; rs1895872; rs8192344; rs8192348; rs2856931; rs35664254; rs2607082; rs2607083; rs1044144; rs1044151; rs10851850; rs12324744; rs12443060; rs1457030; rs2959901; rs35285520; rs35378070; rs4238451; rs4777492; rs7173348

# Metabolic_Enzyme_11_General_References:
2854097; 2813362; 2040271; 12665801; 9466265

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
6041

# Metabolic_Enzyme_12_Name:
Pyruvate kinase isozymes R/L

# Metabolic_Enzyme_12_Synonyms:
R-type/L-type pyruvate kinase; Red cell/liver pyruvate kinase; Pyruvate kinase 1

# Metabolic_Enzyme_12_Gene_Name:
PKLR

# Metabolic_Enzyme_12_Protein_Sequence:
>Pyruvate kinase isozymes R/L
MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQ
LPAAMADTFL
EHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNF
SHGSHEYHAESIANVREAVES
FAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELV
KGSQVLVTVDPAFRTRGNANTVWVDYPNIVRV
VPVGGRIYIDDGLISLVVQKIGPEGLV
TQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGV
DIVFASFVRKASDVAA
VRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVF
LAQKM
MIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPV
EAVKM
QHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVL
TTTGRSAQLLSRYRPR
AAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRV
QFGIESGKLRGFLRVGDLVIVVTGWRP
GSGYTNIMRVLSIS

# Metabolic_Enzyme_12_Number_of_Residues:
574

# Metabolic_Enzyme_12_Molecular_Weight:
61831

# Metabolic_Enzyme_12_Theoretical_pI:
7.83

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  pyruvate kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_12_Specific_Function:
ATP + pyruvate = ADP + phosphoenolpyruvate

# Metabolic_Enzyme_12_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00230  Purine metabolism;
 map00620  Pyruvate metabolism;
 map00710  Carbon fixation

# Metabolic_Enzyme_12_Reaction:
ATP + pyruvate = ADP + phosphoenolpyruvate

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00224:PK;
PF02887:PK_C

# Metabolic_Enzyme_12_Signals:
None

# Metabolic_Enzyme_12_Transmembrane_Regions:
None

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 2.7.1.40

# Metabolic_Enzyme_12_GenBank_ID_Protein:
3327365

# Metabolic_Enzyme_12_SwissProt_ID:
KPYR_HUMAN (P30613)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
PKLR

# Metabolic_Enzyme_12_Geneatlas_id:
PKLR

# Metabolic_Enzyme_12_hgnc_id:
HGNC:9020

# Metabolic_Enzyme_12_PDB_ID:
1LIU

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Not Available

# Metabolic_Enzyme_12_Gene_Sequence:
>1725 bp

ATGTCGATCCAGGAGAACATATCATCCCTGCAGCTTCGGTCATGGGTCTCTAAGTCCCA
AAGAGACTTAG
CAAAGTCCATCCTGATTGGGGCTCCAGGAGGGCCAGCGGGGTATCTGC
GGCGGGCCAGTGTGGCCCAACT
GACCCAGGAGCTGGGCACTGCCTTCTTCCAGCAGCAG
CAGCTGCCAGCTGCTATGGCAGACACCTTCCTG
GAACACCTCTGCCTACTGGACATTGA
CTCCGAGCCCGTGGCTGCTCGCAGTACCAGCATCATTGCCACCA
TCGGGCCAGCATCTC
GCTCCGTGGAGCGCCTCAAGGAGATGATCAAGGCCGGGATGAACATTGCGCGACT
CAAC
TTCTCCCACGGCTCCCACGAGTACCATGCTGAGTCCATCGCCAACGTCCGGGAGGCGGTG
GAGAGC
TTTGCAGGTTCCCCACTCAGCTACCGGCCCGTGGCCATCGCCCTGGACACCAA
GGGACCGGAGATCCGCA
CTGGGATCCTGCAGGGGGGTCCAGAGTCGGAAGTGGAGCTGG
TGAAGGGCTCCCAGGTGCTGGTGACTGT
GGACCCCGCGTTCCGGACGCGGGGGAACGCG
AACACCGTGTGGGTGGACTACCCCAATATTGTCCGGGTC
GTGCCGGTGGGGGGCCGCAT
CTACATTGACGACGGGCTCATCTCCCTAGTGGTCCAGAAAATCGGCCCAG
AGGGACTGG
TGACCCAAGTGGAGAACGGCGGCGTCCTGGGCAGCCGGAAGGGCGTGAACTTGCCAGGGG
C
CCAGGTGGACTTGCCCGGGCTGTCCGAGCAGGACGTCCGAGACCTGCGCTTCGGGGTG
GAGCATGGGGTG
GACATCGTCTTTGCCTCCTTTGTGCGGAAAGCCAGCGACGTGGCTGC
CGTCAGGGCTGCTCTGGGTCCGG
AAGGACACGGCATCAAGATCATCAGCAAAATTGAGA
ACCACGAAGGCGTGAAGAGGTTTGATGAAATCCT
GGAGGTGAGCGACGGCATCATGGTG
GCACGGGGGGACCTAGGCATCGAGATCCCAGCAGAGAAGGTTTTC
CTGGCTCAGAAGAT
GATGATTGGGCGCTGCAACTTGGCGGGCAAGCCTGTTGTCTGTGCCACACAGATGC
TGG
AGAGCATGATTACCAAGCCCCGGCCAACGAGGGCAGAGACAAGCGATGTCGCCAATGCTG
TGCTGGA
TGGGGCTGACTGCATCATGCTGTCAGGGGAGACTGCCAAGGGCAACTTCCCT
GTGGAAGCGGTGAAGATG
CAGCATGCGATTGCCCGGGAGGCAGAGGCCGCAGTGTACCA
CCGGCAGCTGTTTGAGGAGCTACGTCGGG
CAGCGCCACTAAGCCGTGATCCCACTGAGG
TCACCGCCATTGGTGCTGTGGAGGCTGCCTTCAAGTGCTG
TGCTGCTGCCATCATTGTG
CTGACCACAACTGGCCGCTCAGCCCAGCTTCTGTCTCGGTACCGACCTCGG
GCAGCAGT
CATTGCTGTCACCCGCTCTGCCCAGGCTGCCCGCCAGGTCCACTTATGCCGAGGAGTCTT
CC
CCTTGCTTTACCGTGAACCTCCAGAAGCCATCTGGGCAGATGATGTAGATCGCCGGG
TGCAATTTGGCAT
TGAAAGTGGAAAGCTCCGTGGCTTCCTCCGTGTTGGAGACCTGGTG
ATTGTGGTGACAGGCTGGCGACCT
GGCTCCGGCTACACCAACATCATGAGGGTGCTAAG
CATATCCTGA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
AB015983

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_12_Locus:
1q21

# Metabolic_Enzyme_12_SNPs:
rs1052176; rs8177962; rs1052177; rs4620533; rs3762272; rs8177970; rs8177963; rs3020781; rs8177971; rs8177967; rs8177973; rs8177964; rs12067675; rs11264357; rs8177992; rs8177990; rs8177972; rs8177991; rs8177966; rs2071053; rs11264356; rs8177976; rs8177987; rs8177968; rs8177960; rs7524950; rs8177988; rs8177974; rs8177994; rs35957800; rs3020786; rs8177980; rs3020784; rs2990219; rs8177977; rs8177986; rs35869567; rs8177993; rs34562839; rs8177969; rs11802924; rs3020785; rs8177989; rs8177978; rs8177983; rs10565071; rs12040032; rs35792920; rs12032821; rs8177982; rs8177985; rs3020782; rs8177975; rs8177984; rs8177979; rs3020783; rs8177981; rs12741350; rs8177961; rs8177965; rs2990218; rs35700340; rs34748987; rs12037847; rs35615990; rs11264351; rs11264352; rs11264355; rs12032720; rs12033064; rs12043597; rs12049375; rs12118947; rs12239421; rs12726199; rs1888929; rs2297480; rs34218829; rs35001694; rs35362111; rs3814319; rs4971072; rs7520184; rs8847; rs932972

# Metabolic_Enzyme_12_General_References:
1896471; 3126495; 3566732; 8476433; 8664896; 8807089; 9075576; 10087985; 10772876; 2018831; 1536957; 8481523; 8483951; 8161798; 8180378; 7706479; 9090535; 9827908; 9886305; 9482576; 11328279

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
6009

# Metabolic_Enzyme_13_Name:
6-phosphofructokinase type C

# Metabolic_Enzyme_13_Synonyms:
Phosphofructokinase 1; Phosphohexokinase; Phosphofructo-1-kinase isozyme C; PFK-C; 6- phosphofructokinase, platelet type

# Metabolic_Enzyme_13_Gene_Name:
PFKP

# Metabolic_Enzyme_13_Protein_Sequence:
>6phosphofructokinase type 
CMDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYF
IYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGI
TNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFC
GTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFL
PESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYD
TRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLME
CVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVG
APAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGT
KRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATV
SNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAG
ADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGK
GVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICV
LGISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHV
QPWSV

# Metabolic_Enzyme_13_Number_of_Residues:
784

# Metabolic_Enzyme_13_Molecular_Weight:
85597

# Metabolic_Enzyme_13_Theoretical_pI:
7.60

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  phosphofructokinase activity
Function:  6-phosphofructokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  protein complex
Component:  6-phosphofructokinase complex
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_13_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_13_Specific_Function:
ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

# Metabolic_Enzyme_13_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00030  Pentose phosphate pathway;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism

# Metabolic_Enzyme_13_Reaction:
ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF00365:PFK

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
None

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 2.7.1.11

# Metabolic_Enzyme_13_GenBank_ID_Protein:
560105

# Metabolic_Enzyme_13_SwissProt_ID:
K6PP_HUMAN (Q01813)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
PFKP

# Metabolic_Enzyme_13_Geneatlas_id:
PFKP

# Metabolic_Enzyme_13_hgnc_id:
HGNC:8878

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Not Available

# Metabolic_Enzyme_13_Gene_Sequence:
>2355 bp
ATGGACGCGGACGACTCCCGGGCCCCCAAGGGCTCCTTGCGGAAGTTCCTGGAGCACCTC
TCCGGGGCCGGCAAGGCCATCGGCGTGCTGACCAGCGGCGGGGATGCTCAAGGTATGAAC
GCTGCCGTCCGTGCCGTGGTGCGCATGGGTATCTACGTGGGGGCCAAGGTGTACTTCATC
TACGAGGGCTACCAGGGCATGGTGGACGGAGGCTCAAACATCGCAGAGGCCGACTGGGAG
AGTGTCTCCAGCATCCTGCAAGTGGGCGGGACGATCATTGGCAGTGCGCGGTGCCAGGCC
TTCCGCACGCGGGAAGGCCGCCTGAAGGCTGCTTGCAACCTGCTGCAGCGCGGCATCACC
AACCTGTGTGTGATCGGCGGGGACGGGAGCCTCACCGGGGCCAACCTCTTCCGGAAGGAG
TGGAGTGGGCTGCTGGAGGAGCTGGCCAGGAACGGCCAGATCGATAAGGAGGCCGTGCAG
AAGTACGCCTACCTCAACGTGGTGGGCATGGTGGGCTCCATCGACAATGATTTCTGCGGC
ACCGACATGACCATCGGCACGGACTCCGCCCTGCACAGGATCATCGAGGTCGTCGACGCC
ATCATGACCACGGCCCAGAGCCACCAGAGGACCTTCGTTCTGGAGGTGATGGGACGACAC
TGTGGGTACCTGGCCCTGGTGAGTGCCTTGGCCTGCGGTGCGGACTGGGTGTTCCTTCCA
GAATCTCCACCAGAGGAAGGCTGGGAGGAGCAGATGTGTGTCAAACTCTCGGAGAACCGT
GCCCGGAAAAAAAGGCTGAATATTATTATTGTGGCTGAAGGAGCAATTGATACCCAAAAT
AAACCCATCACCTCTGAGAAAATCAAAGAGCTTGTCGTCACGCAGCTGGGCTATGACACA
CGTGTGACCATCCTCGGGCACGTGCAGAGAGGAGGGACCCCTTCGGCATTCGACAGGATC
TTGGCCAGCCGCATGGGAGTGGAGGCAGTCATCGCCTTGCTAGAGGCCACCCCGGACACC
CCAGCTTGCGTCGTGTCACTGAACGGGAACCACGCCGTGCGCCTGCCGCTGATGGAGTGC
GTGCAGATGACTCAGGATGTGCAGAAGGCGATGGACGAGAGGAGATTTCAAGATGCGGTT
CGACTCCGAGGGAGGAGCTTTGCGGGCAACCTGAACACCTACAAGCGACTTGCCATCAAG
CTGCCGGATGATCAGATCCCAAAGACCAATTGCAACGTAGCTGTCATCAACGTGGGGGCA
CCCGCGGCTGGGATGAACGCGGCCGTACGCTCAGCTGTGCGCGTGGGCATTGCCGACGGC
CACAGGATGCTCGCCATCTATGATGGCTTTGACGGCTTCGCCAAGGGCCAGATCAAAGAA
ATCGGCTGGACAGATGTCGGGGGCTGGACCGGCCAAGGAGGCTCCATTCTTGGGACAAAA
CGCGTTCTCCCGGGGAAGTACTTGGAAGAGATCGCCACACAGATGCGCACGCACAGCATC
AACGCGCTGCTGATCATCGGTGGATTCGAGGCCTACCTGGGACTCCTGGAGCTGTCAGCC
GCCCGGGAGAAGCACGAGGAGTTCTGTGTCCCCATGGTCATGGTTCCCGCTACTGTGTCC
AACAATGTGCCGGGTTCCGATTTCAGCATCGGGGCAGACACCGCCCTGAACACTATCACC
GACACCTGCGACCGCATCAAGCAGTCCGCCAGCGGAACCAAGCGGCGCGTGTTCATCATC
GAGACCATGGGCGGCTACTGTGGCTACCTGGCCAACATGGGGGGGCTCGCGGCCGGAGCT
GATGCCGCATACATTTTCGAAGAGCCCTTCGACATCAGGGATCTGCAGTCCAACGTGGAG
CACCTGACGGAGAAAATGAAGACCACCATCCAGAGAGGCCTTGTGCTCAGAAATGAGAGC
TGCAGTGAAAACTACACCACCGACTTCATTTACCAGCTGTATTCAGAAGAGGGCAAAGGC
GTGTTTGACTGCAGGAAGAACGTGCTGGGTCACATGCAGCAGGGTGGGGCACCCTCTCCA
TTTGATAGAAACTTTGGAACCAAAATCTCTGCCAGAGCTATGGAGTGGATCACTGCAAAA
CTCAAGGAGGCCCGGGGCAGAGGAAAAAAATTTACCACCGATGATTCCATTTGTGTGCTG
GGAATAAGCAAAAGAAACGTTATTTTTCAACCTGTGGCAGAGCTGAAGAAGCAAACGGAT
TTTGAGCACAGGATTCCCAAAGAACAGTGGTGGCTCAAGCTACGGCCCCTCATGAAAATC
CTGGCCAAGTACAAGGCCAGCTATGACGTGTCGGACTCAGGCCAGCTGGAACATGTGCAG
CCCTGGAGTGTCTGA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
D25328

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_13_Locus:
10p15.3-p15.2

# Metabolic_Enzyme_13_SNPs:
rs2306302; rs1132173; rs4881086; rs12572717; rs1052333; rs1052309; rs11251721; rs11542779; rs11542777; rs11542780; rs1052337; rs35828349; rs4881080; rs3816699; rs9063; rs1052929; rs1053000; rs542; rs543; rs541; rs7673; rs3816712; rs2388564; rs867274; rs2388595; rs2306294; rs2306297; rs7901550; rs2306310; rs7913237; rs2279211; rs10508245; rs2388510; rs6602029; rs2892550; rs3814587; rs4881099; rs7080240; rs6602028; rs2306312; rs3829915; rs2306304; rs7896691; rs7086721; rs7923989; rs7916889; rs6602030; rs2279215; rs6602027; rs4881091; rs2306311; rs2279212; rs7922072; rs4391741; rs2388594; rs10795000; rs4611105; rs3814590; rs730141; rs9423693; rs7100185; rs4881101; rs4390256; rs2306305; rs4881084; rs2279208; rs882849; rs7913473; rs7902549; rs7096334; rs4545444; rs7082863; rs2306299; rs7924111; rs4381274; rs4880592; rs10903969; rs9630129; rs7075489; rs7096442; rs12268267; rs11819604; rs11251702; rs7076989; rs2306293; rs12569790; rs11817505; rs12570754; rs7082524; rs17284739; rs9423690; rs2388565; rs4881105; rs4881098; rs10508246; rs7918368; rs11251694; rs10903970; rs4881074; rs10903959; rs4881085; rs4517415; rs2388566; rs7342021; rs2306309; rs7894036; rs10794999; rs4881075; rs12569846; rs7091322; rs10903967; rs9423462; rs10903972; rs11251727; rs2388569; rs7901589; rs11591441; rs3829914; rs4598574; rs3816698; rs4881093; rs9423474; rs11251724; rs3740613; rs2306307; rs2306314; rs9423467; rs7896260; rs10903974; rs2892554; rs4595438; rs4881079; rs2388567; rs17131897; rs3816701; rs9423466; rs11592061; rs11251697; rs7086902; rs11251741; rs2306316; rs3814588; rs12257705; rs10903962; rs7080058; rs11599851; rs7910054; rs17212803; rs872398; rs17132175; rs2306306; rs9423487; rs2306315; rs6602032; rs10903955; rs10903961; rs3814589; rs4306207; rs11818475; rs4881077; rs9423680; rs4881087; rs9423489; rs2279210; rs7075876; rs9423490; rs6602031; rs11251723; rs12762657; rs11812979; rs11251711; rs10903954; rs12776036; rs4881097; rs7083162; rs2279206; rs4269839; rs7094776; rs7903250; rs9423491; rs10751913; rs12253549; rs7915793; rs7906901; rs2388570; rs3842695; rs9804219; rs3829917; rs11251719; rs12572060; rs4881082; rs4256893; rs9423471; rs10903960; rs17132578; rs2279207; rs7091146; rs7896897; rs7071398; rs12415723; rs9423464; rs7918168; rs11251729; rs4880590; rs7902539; rs4999370; rs9804221; rs2388552; rs7907949; rs9423681; rs11251732; rs11251707; rs4881081; rs7900748; rs10795002; rs11815740; rs17285851; rs4881078; rs3829916; rs7896829; rs7074733; rs11251709; rs9423685; rs12247270; rs11598339; rs10903968; rs7898894; rs3740611; rs7900171; rs17135865; rs2279204; rs4271292; rs12412712; rs9423469; rs10430751; rs9423472; rs11251696; rs7915264; rs12769974; rs9423692; rs11592619; rs4881095; rs7913254; rs7094648; rs11251742; rs11251695; rs9423691; rs2306301; rs2279209; rs7090199; rs9423698; rs7909171; rs3816703; rs4469783; rs10751914; rs10903966; rs3740610; rs11818602; rs9423473; rs2279205; rs1107048; rs11251734; rs11251728; rs2388571; rs9423485; rs7076698; rs11251710; rs11591990; rs6602023; rs9423494; rs4391742; rs8181285; rs2388573; rs4424569; rs10795004; rs9423695; rs3829912; rs11595224; rs11251715; rs7088110; rs10903957; rs10903973; rs7916196; rs7893663; rs10795005; rs11251720; rs4881094; rs9423476; rs4881089; rs10903963; rs3829911; rs2388574; rs4881100; rs9423475; rs9423686; rs2279213; rs10903958; rs6602026; rs3842696; rs7901291; rs9423477; rs3740612; rs7896500; rs2279203; rs10751912; rs2388568; rs4281389; rs6602022; rs7079667; rs872399; rs11251730; rs9804296; rs9423697; rs4881090; rs9423492; rs2388551; rs11251693; rs11595461; rs3814591; rs4881088; rs11595530; rs9423689; rs12357621; rs11591423; rs12414599; rs7914782; rs12245370; rs12258216; rs7074889; rs10458792; rs10430770; rs2388592; rs12358995; rs3816700; rs10903953; rs10795003; rs7100037; rs11251733; rs12772110; rs4881083; rs6602024; rs4881092; rs9423470; rs9423479; rs3830218; rs10508244; rs2388550; rs7902685; rs7342119; rs4589191; rs2306308; rs2388563; rs4881106; rs12772817; rs7079217; rs2388562; rs41288721; rs11542782; rs11542778; rs34180069; rs17852638; rs41288715; rs11542781; rs3816704; rs3841604; rs11251743; rs34020709; rs9423465; rs11419779; rs12249060; rs9423481; rs11251716; rs12246252; rs35454947; rs10552241; rs10528387; rs12571307; rs2306318; rs7903389; rs4991347; rs35621470; rs2306303; rs34612453; rs11251703; rs36062383; rs41288731; rs41285619; rs41288717; rs35044971; rs36124101; rs34773391; rs7914040; rs10611976; rs36123078; rs10458791; rs35763309; rs7342088; rs35304719; rs7893811; rs34970131; rs10673964; rs9423483; rs7087044; rs11312438; rs9423682; rs35870724; rs41288727; rs7911657; rs9423480; rs11251712; rs35129023; rs11473992; rs35998692; rs34554786; rs7078002; rs10606109; rs10458790; rs12243817; rs35551233; rs10578594; rs41288713; rs4991348; rs34810963; rs6143743; rs2388572; rs10552310; rs11251726; rs9423482; rs7083310; rs11599643; rs11593072; rs33926028; rs9423463; rs6602025; rs12571292; rs4002022; rs35375917; rs34822234; rs34387880; rs41288719; rs11418900; rs34547664; rs34978134; rs5782687; rs10736966; rs5782680; rs10795006; rs10795001; rs7921605; rs11251717; rs34543032; rs11251705; rs4575170; rs2306317; rs4881096; rs11364694; rs41288729; rs9423684; rs35591312; rs5782685; rs3841457; rs11251708; rs34980049; rs34937212; rs10606110; rs7911305; rs3892593; rs7917172; rs34361470; rs7903088; rs4881076; rs11251704; rs9423461; rs35755098; rs34626444; rs35455312; rs7342001; rs2388591; rs36089632; rs9630123; rs5782686; rs4584487; rs10903964; rs9423688; rs41288711; rs34625271; rs34795068; rs35308134; rs34196028; rs33989675; rs12267216; rs11251698; rs35246156; rs3830217; rs11426937; rs10903965; rs5782683; rs35671672; rs10082547; rs9423484; rs12411383; rs2306300; rs11251740; rs9423460; rs35879516; rs2306296; rs9423687; rs34920157; rs11251737; rs7072300; rs34441916; rs7905464; rs12775265; rs11251736; rs34485324; rs12249143; rs35163491; rs3829913; rs35686601; rs11251731; rs9423694; rs35648106; rs3042667; rs11394580; rs28673062; rs12767011; rs12355909; rs7912275; rs11251725; rs5782684; rs12762623; rs34538474; rs7921718; rs28433695; rs35568047; rs12777199; rs35863365; rs12772744; rs34260521; rs6143744; rs12769056; rs2388575; rs12773602; rs7913100; rs11251739; rs2892549; rs35072017; rs11251701; rs11251714; rs4880589; rs34688896; rs35741420; rs11251706; rs35276282; rs11375841; rs11251722; rs2306298; rs12411396; rs12769988; rs35751635; rs34430271; rs12250915; rs35571366; rs35303123; rs41288723; rs2388576; rs7071824; rs4880591; rs34453449; rs41288733; rs5782681; rs9423478; rs11251699; rs7072286; rs6143745; rs34390372; rs9702390; rs12355948; rs34128386; rs34273901; rs7896922; rs7919798; rs7474978; rs35768855; rs12412657; rs11251700; rs11251738; rs7898754; rs7082466; rs7071339; rs10582528; rs34600605; rs7088709; rs35381145; rs7093888; rs5782682; rs11251718; rs10903956; rs2306313; rs12571066; rs35890906; rs9423486; rs6143747; rs6143746; rs10175; rs1043146; rs1043158; rs1043166; rs10508247; rs10736965; rs10751909; rs10794997; rs10794998; rs10795007; rs11251688; rs11251744; rs12678; rs12762013; rs12774814; rs12779561; rs12780595; rs17135477; rs17136264; rs17212411; rs17849904; rs1802344; rs1804254; rs2279216; rs2279217; rs2279218; rs2279219; rs2279220; rs2279221; rs2306319; rs2388558; rs2388559; rs2388560; rs2388561; rs34837384; rs34882494; rs35301243; rs35363509; rs35779348; rs3752802; rs3752803; rs3758630; rs3758631; rs3814586; rs4451611; rs4880594; rs4880595; rs4881107; rs4881109; rs4881110; rs6901; rs7081092; rs7094698; rs7097793; rs7898290; rs7898695; rs7904857; rs7908746; rs7911918; rs7924163; rs9129; rs9423495; rs9423701; rs9423702; rs9423703

# Metabolic_Enzyme_13_General_References:
8117307; 1834056

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5339

# Metabolic_Enzyme_14_Name:
Nucleoside diphosphate kinase homolog 5

# Metabolic_Enzyme_14_Synonyms:
NDK-H 5; NDP kinase homolog 5; nm23-H5; Testis-specific nm23 homolog; Inhibitor of p53-induced apoptosis-beta; IPIA-beta

# Metabolic_Enzyme_14_Gene_Name:
NME5

# Metabolic_Enzyme_14_Protein_Sequence:
>Nucleoside diphosphate kinase homolog 5
MEISMPPPQIYVEKTLAIIKPDIVDKEEEIQDIILRSGFTIVQRRKLRLSPEQCSNFYVE
KYGKMFFPNLTAYMSSGPLVAMILARHKAISYWLELLGPNNSLVAKETHPDSLRAIYGTD
DLRNALHGSNDFAAAEREIRFMFPEVIVEPIPIGQAAKDYLNLHIMPTLLEGLTELCKQK
PADPLIWLADWLLKNNPNKPKLCHHPIVEEPY

# Metabolic_Enzyme_14_Number_of_Residues:
212

# Metabolic_Enzyme_14_Molecular_Weight:
24237

# Metabolic_Enzyme_14_Theoretical_pI:
6.25

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  nucleoside diphosphate kinase activity
 ||
>>>
Process:  CTP biosynthesis
Process:  nucleoside triphosphate metabolism
Process:  nucleoside triphosphate biosynthesis
Process:  ribonucleoside triphosphate biosynthesis
Process:  pyrimidine ribonucleoside triphosphate biosynthesis
Process:  UTP biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside triphosphate biosynthesis
Process:  purine ribonucleoside triphosphate biosynthesis
Process:  GTP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species

# Metabolic_Enzyme_14_Pathway:
Not Available

# Metabolic_Enzyme_14_Reaction:
Not Available

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF05186:Dpy-30;
PF00334:NDK

# Metabolic_Enzyme_14_Signals:
None

# Metabolic_Enzyme_14_Transmembrane_Regions:
None

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 2.7.4.6

# Metabolic_Enzyme_14_GenBank_ID_Protein:
3559927

# Metabolic_Enzyme_14_SwissProt_ID:
NDK5_HUMAN (P56597)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
NME5

# Metabolic_Enzyme_14_Geneatlas_id:
NME5

# Metabolic_Enzyme_14_hgnc_id:
HGNC:7853

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Not Available

# Metabolic_Enzyme_14_Gene_Sequence:
>639 bp
ATGGAGATATCAATGCCTCCACCTCAGATATATGTAGAAAAAACTCTGGCCATTATCAAA
CCAGATATTGTTGACAAAGAGGAGGAGATACAAGATATTATTCTTAGATCCGGATTCACC
ATTGTTCAGAGAAGAAAACTACGCCTCAGCCCTGAGCAATGTAGTAACTTTTATGTGGAA
AAGTATGGAAAAATGTTTTTCCCCAACTTAACAGCTTACATGAGTTCTGGACCACTTGTC
GCCATGATATTAGCTAGACATAAAGCCATCTCTTATTGGTTAGAACTTTTGGGACCAAAT
AATAGCTTAGTAGCGAAGGAGACACATCCAGACAGTCTGAGGGCAATTTATGGCACAGAT
GACCTAAGGAATGCACTTCATGGGAGTAATGACTTTGCTGCTGCGGAAAGAGAAATACGT
TTTATGTTTCCTGAAGTGATTGTTGAGCCCATTCCAATTGGACAAGCTGCTAAGGACTAT
TTAAATTTACATATAATGCCAACTCTGCTTGAAGGACTCACAGAGCTTTGTAAGCAAAAA
CCAGCAGACCCTTTGATTTGGCTAGCTGATTGGCTGCTGAAAAATAATCCTAACAAACCC
AAACTTTGTCACCATCCAATTGTAGAAGAACCTTATTAA

# Metabolic_Enzyme_14_GenBank_ID_Gene:
Y14992

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_14_Locus:
5q31

# Metabolic_Enzyme_14_SNPs:
rs4835669; rs3849045; rs11738864; rs435570; rs486835; rs370883; rs486799; rs6874360; rs10041215; rs2286062; rs217275; rs6886939; rs217257; rs10061967; rs6874361; rs217265; rs11749224; rs10070451; rs34855110; rs1048921; rs1048930; rs217279; rs188654; rs7732940; rs217276; rs34623624; rs9687237; rs217278; rs11428296; rs13163071; rs34303869; rs35881974; rs217277; rs13163059; rs36105476; rs191968; rs35122788; rs34325179; rs4493669; rs407345; rs488701; rs12519826; rs35219466; rs6878575; rs17171760; rs34413149; rs217280; rs184268; rs217266; rs35475097; rs11411365; rs6886543; rs10463966; rs13186134; rs34216437; rs11461484; rs10076479; rs35131457; rs34858006; rs35500548; rs11403625; rs170087; rs35226190; rs11333316; rs13185644; rs12516561; rs13357290; rs217263; rs2306111; rs34936068; rs35406608; rs412051; rs423258; rs4835768; rs528729; rs529526; rs7720650

# Metabolic_Enzyme_14_General_References:
9742940

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5313

# Metabolic_Enzyme_15_Name:
Ectonucleoside triphosphate diphosphohydrolase 1

# Metabolic_Enzyme_15_Synonyms:
NTPDase 1; Ecto-ATP diphosphohydrolase; ATPDase; Lymphoid cell activation antigen; Ecto-apyrase; CD39 antigen

# Metabolic_Enzyme_15_Gene_Name:
ENTPD1

# Metabolic_Enzyme_15_Protein_Sequence:
>Ectonucleoside triphosphate diphosphohydrolase 1
MEDTKESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENVKYGIVLDAGSSHT
SLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQ
HQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWI
TINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFR
LYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTP
CTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAF
SAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYIL
SLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVFL
MVLFSLVLFTVAIIGLLIFHKPSYFWKDMV

# Metabolic_Enzyme_15_Number_of_Residues:
510

# Metabolic_Enzyme_15_Molecular_Weight:
57965

# Metabolic_Enzyme_15_Theoretical_pI:
6.29

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Not Available

# Metabolic_Enzyme_15_Specific_Function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation. Hydrolyzes ATP and ADP equally well

# Metabolic_Enzyme_15_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_15_Reaction:
ATP + 2 H2O = AMP + 2 phosphate

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF01150:GDA1_CD39

# Metabolic_Enzyme_15_Signals:
None

# Metabolic_Enzyme_15_Transmembrane_Regions:
17-37
479-499

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 3.6.1.5

# Metabolic_Enzyme_15_GenBank_ID_Protein:
765256

# Metabolic_Enzyme_15_SwissProt_ID:
ENTP1_HUMAN (P49961)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
ENTPD1

# Metabolic_Enzyme_15_Geneatlas_id:
ENTPD1

# Metabolic_Enzyme_15_hgnc_id:
HGNC:3363

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential)

# Metabolic_Enzyme_15_Gene_Sequence:
>1533 bp
ATGGAAGATACAAAGGAGTCTAACGTGAAGACATTTTGCTCCAAGAATATCCTAGCCATC
CTTGGCTTCTCCTCTATCATAGCTGTGATAGCTTTGCTTGCTGTGGGGTTGACCCAGAAC
AAAGCATTGCCAGAAAACGTTAAGTATGGGATTGTGCTGGATGCGGGTTCTTCTCACACA
AGTTTATACATCTATAAGTGGCCAGCAGAAAAGGAGAATGACACAGGCGTGGTGCATCAA
GTAGAAGAATGCAGGGTTAAAGGTCCTGGAATCTCAAAATTTGTTCAGAAAGTAAATGAA
ATAGGCATTTACCTGACTGATTGCATGGAAAGAGCTAGGGAAGTGATTCCAAGGTCCCAG
CACCAAGAGACACCCGTTTACCTGGGAGCCACGGCAGGCATGCGGTTGCTCAGGATGGAA
AGTGAAGAGTTGGCAGACAGGGTTCTGGATGTGGTGGAGAGGAGCCTCAGCAACTACCCC
TTTGACTTCCAGGGTGCCAGGATCATTACTGGCCAAGAGGAAGGTGCCTATGGCTGGATT
ACTATCAACTATCTGCTGGGCAAATTCAGTCAGAAAACAAGGTGGTTCAGCATAGTCCCA
TATGAAACCAATAATCAGGAAACCTTTGGAGCTTTGGACCTTGGGGGAGCCTCTACACAA
GTCACTTTTGTACCCCAAAACCAGACTATCGAGTCCCCAGATAATGCTCTGCAATTTCGC
CTCTATGGCAAGGACTACAATGTCTACACACATAGCTTCTTGTGCTATGGGAAGGATCAG
GCACTCTGGCAGAAACTGGCCAAGGACATTCAGGTTGCAAGTAATGAAATTCTCAGGGAC
CCATGCTTTCATCCTGGATATAAGAAGGTAGTGAACGTAAGTGACCTTTACAAGACCCCC
TGCACCAAGAGATTTGAGATGACTCTTCCATTCCAGCAGTTTGAAATCCAGGGTATTGGA
AACTATCAACAATGCCATCAAAGCATCCTGGAGCTCTTCAACACCAGTTACTGCCCTTAC
TCCCAGTGTGCCTTCAATGGGATTTTCTTGCCACCACTCCAGGGGGATTTTGGGGCATTT
TCAGCTTTTTACTTTGTGATGAAGTTTTTAAACTTGACATCAGAGAAAGTCTCTCAGGAA
AAGGTGACTGAGATGATGAAAAAGTTCTGTGCTCAGCCTTGGGAGGAGATAAAAACATCT
TACGCTGGAGTAAAGGAGAAGTACCTGAGTGAATACTGCTTTTCTGGTACCTACATTCTC
TCCCTCCTTCTGCAAGGCTATCATTTCACAGCTGATTCCTGGGAGCACATCCATTTCATT
GGCAAGATCCAGGGCAGCGACGCCGGCTGGACTTTGGGCTACATGCTGAACCTGACCAAC
ATGATCCCAGCTGAGCAACCATTGTCCACACCTCTCTCCCACTCCACCTATGTCTTCCTC
ATGGTTCTATTCTCCCTGGTCCTTTTCACAGTGGCCATCATAGGCTTGCTTATCTTTCAC
AAGCCTTCATATTTCTGGAAAGATATGGTATAG

# Metabolic_Enzyme_15_GenBank_ID_Gene:
S73813

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_15_Locus:
10q24

# Metabolic_Enzyme_15_SNPs:
rs3793744; rs3181132; rs1342790; rs3176883; rs3181124; rs1573112; rs3176891; rs2153913; rs3176890; rs10748643; rs7077566; rs4431963; rs6584033; rs4582902; rs10882665; rs6584026; rs2185818; rs10748649; rs4075310; rs3176881; rs5014871; rs7097489; rs7919196; rs4481960; rs4918968; rs10882664; rs1891534; rs7096610; rs10509686; rs7083960; rs4322324; rs3892344; rs3181123; rs4396219; rs4512761; rs4917715; rs7921242; rs7074403; rs1891536; rs4244321; rs2861152; rs1418709; rs3181131; rs2275759; rs4075311; rs10882671; rs4917714; rs1340837; rs6584027; rs3176885; rs7088952; rs12262943; rs11598475; rs4320886; rs17111156; rs11188486; rs10882676; rs7096248; rs3929900; rs4918969; rs4551688; rs7093453; rs3897983; rs2901874; rs10882673; rs4918971; rs2901873; rs2861153; rs6584031; rs10736092; rs7893677; rs3181129; rs4917707; rs11188497; rs7088961; rs7902190; rs10882660; rs2105359; rs6584028; rs7901116; rs7913082; rs10736093; rs3176884; rs7900927; rs4614366; rs10786236; rs2901872; rs7067762; rs11188485; rs7089668; rs4409759; rs7070507; rs11595122; rs10882670; rs10786235; rs1539433; rs7100137; rs7088584; rs11818540; rs10748648; rs4336964; rs10882675; rs1342791; rs4074424; rs4918970; rs3181122; rs12767650; rs3901451; rs11816167; rs11188475; rs3181121; rs7915345; rs3176887; rs2861151; rs6584030; rs4412693; rs11594340; rs7921000; rs7894940; rs3176882; rs7898379; rs11188496; rs3181118; rs3176886; rs10882661; rs10882666; rs7901386; rs2275760; rs7090320; rs12770849; rs3181125; rs7915682; rs3901450; rs11188501; rs10786237; rs7900546; rs10748644; rs10786234; rs7915087; rs7913018; rs7894676; rs7914736; rs1935816; rs1418710; rs10748645; rs10786233; rs7069234; rs4406763; rs10882662; rs11188502; rs7915308; rs3176889; rs7095489; rs11593761; rs7082531; rs7914286; rs2861154; rs7083411; rs3176888; rs10882663; rs7920372; rs10748647; rs12780375; rs12354848; rs7476775; rs11188484; rs11188495; rs12763743; rs10882668; rs4272738; rs11188488; rs7900841; rs7921302; rs11188492; rs10786238; rs12244606; rs7915499; rs10882669; rs11188498; rs7904990; rs11592584; rs12770313; rs10882674; rs11188504; rs3181127; rs7915380; rs3176894; rs3814159; rs3176893; rs3176895; rs3176892; rs1804825; rs12240959; rs4463786; rs34293555; rs34399092; rs35135296; rs11389794; rs3980180; rs10736091; rs11407296; rs11188487; rs11597953; rs11188493; rs5787157; rs4472866; rs4539246; rs34736818; rs34473397; rs35488296; rs35597960; rs4420188; rs35620983; rs5787162; rs9663685; rs35826614; rs7900437; rs34166835; rs10585205; rs11188508; rs34177114; rs36017526; rs3181128; rs10672739; rs4581382; rs5787158; rs12354620; rs12265109; rs11188494; rs11188482; rs4433506; rs34836127; rs34248770; rs35444953; rs35537802; rs3980181; rs34907927; rs35452058; rs34858625; rs7896855; rs35809029; rs11517041; rs11188479; rs35615283; rs34279173; rs12360382; rs34421483; rs34720050; rs34980662; rs35782220; rs11574649; rs11393527; rs7909739; rs7088411; rs12572063; rs34872816; rs12258207; rs5787161; rs11188481; rs11188511; rs28542865; rs35164560; rs4917705; rs7900229; rs11527887; rs35203111; rs3897464; rs34082135; rs34627984; rs35360884; rs11188509; rs34308669; rs35650706; rs11188506; rs4325249; rs35298724; rs35859772; rs11188510; rs5787159; rs1418711; rs11574648; rs34367283; rs34925455; rs34296389; rs11188480; rs11528098; rs34873600; rs7898964; rs34863917; rs11188489; rs34997042; rs3961946; rs35748815; rs35177231; rs12357414; rs11188490; rs12355114; rs34077465; rs35535706; rs35825117; rs35417010; rs9702308; rs4481957; rs35854596; rs11188505; rs7911911; rs5787163; rs34850860; rs12782273; rs11188477; rs11188491; rs12774334; rs3897465; rs11188473; rs9664384; rs11188503; rs33998152; rs11188483; rs4402217; rs35861909; rs35700869; rs3961947; rs35516259; rs11498722; rs5787160; rs34143181; rs10736094; rs11188466; rs11188469; rs11188471; rs11188512; rs11188513; rs11188514; rs12358481; rs12761960; rs12775598; rs12781189; rs17462179; rs17553401; rs1935815; rs2051052; rs2096218; rs2153914; rs2226163; rs3181114; rs3181115; rs3181116; rs3192654; rs34630379; rs34793678; rs4918966; rs6584022; rs6584023; rs7086986; rs7090630; rs7096317; rs7098750; rs7100644; rs7923971

# Metabolic_Enzyme_15_General_References:
7930580; 8996251; 10405171; 8529670; 9846014; 8955160; 8626624; 10636909

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5445

# Metabolic_Enzyme_16_Name:
Hexokinase-2

# Metabolic_Enzyme_16_Synonyms:
Hexokinase type II; HK II; Muscle form hexokinase

# Metabolic_Enzyme_16_Gene_Name:
HK2

# Metabolic_Enzyme_16_Protein_Sequence:
>Hexokinase2
MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAA
VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMR
GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV
EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYME
EMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGM
YMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLG
LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKH
PHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLS
HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV
LLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF
TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG
TMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD
FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG
IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA
VVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKG
AALITAVACRIREAGQR

# Metabolic_Enzyme_16_Number_of_Residues:
917

# Metabolic_Enzyme_16_Molecular_Weight:
102381

# Metabolic_Enzyme_16_Theoretical_pI:
5.93

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Not Available

# Metabolic_Enzyme_16_Specific_Function:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_16_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism;
 map00521  Streptomycin biosynthesis;
 map00530  Aminosugars metabolism

# Metabolic_Enzyme_16_Reaction:
ATP + D-hexose = ADP + D-hexose 6-phosphate

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF00349:Hexokinase_1;
PF03727:Hexokinase_2

# Metabolic_Enzyme_16_Signals:
None

# Metabolic_Enzyme_16_Transmembrane_Regions:
None

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 2.7.1.1

# Metabolic_Enzyme_16_GenBank_ID_Protein:
587202

# Metabolic_Enzyme_16_SwissProt_ID:
HXK2_HUMAN (P52789)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
HK2

# Metabolic_Enzyme_16_Geneatlas_id:
HK2

# Metabolic_Enzyme_16_hgnc_id:
HGNC:4923

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding (By similarity)

# Metabolic_Enzyme_16_Gene_Sequence:
>2754 bp
ATGATTGCCTCGCATCTGCTTGCCTACTTCTTCACGGAGCTCAACCATGACCAAGTGCAG
AAGGTTGACCAGTATCTCTACCACATGCGCCTCTCTGATGAGACCCTCTTGGAGATCTCT
AAGCGGTTCCGCAAGGAGATGGAGAAAGGGCTTGGAGCCACCACTCACCCTACTGCAGCA
GTGAAGATGCTGCCCACCTTTGTGAGGTCCACTCCAGATGGGACAGAACACGGAGAGTTC
CTGGCTCTGGATCTTGGAGGGACCAACTTCCGTGTGCTTTGGGTGAAAGTAACGGACAAT
GGGCTCCAGAAGGTGGAGATGGAGAATCAGATCTATGCCATCCCTGAGGACATCATGCGA
GGCAGTGGCACCCAGCTGTTTGACCACATTGCCGAATGCCTGGCTAACTTCATGGATAAG
CTACAAATCAAAGACAAGAAGCTCCCACTGGGTTTTACCTTCTCGTTCCCCTGCCACCAG
ACTAAACTAGACGAGAGTTTCCTGGTCTCATGGACCAAGGGATTCAAGTCCAGTGGAGTG
GAAGGCAGAGACGTTGTGGCTCTGATCCGGAAGGCCATCCAGAGGAGAGGGGACTTTGAT
ATCGACATTGTGGCTGTGGTGAATGACACAGTTGGGACCATGATGACCTGTGGTTATGAT
GACCACAACTGTGAGATTGGTCTCATTGTGGGCACGGGCAGCAACGCCTGCTACATGGAA
GAGATGCGCCACATCGACATGGTGGAAGGCGATGAGGGGCGGATGTGTATCAATATGGAG
TGGGGGGCCTTCGGGGACGATGGCTCGCTCAACGACATTCGCACTGAGTTTGACCAGGAG
ATTGACATGGGCTCACTGAACCCGGGAAAGCAACTGTTTGAGAAGATGATCAGTGGGATG
TACATGGGGGAGCTGGTGAGGCTTATCCTGGTGAAGATGGCCAAGGAGGAGCTGCTCTTT
GGGGGGAAGCTCAGCCCAGAGCTTCTCAACACCGGTCGCTTTGAGACCAAAGACATCTCA
GACATTGAAGGGGAGAAGGATGGCATCCGGAAGGCCCGTGAGGTCCTGATGCGGTTGGGC
CTGGACCCGACTCAGGAGGACTGCGTGGCCACTCACCGGATCTGCCAGATCGTGTCCACA
CGCTCCGCCAGCCTGTGCGCAGCCACCCTGGCCGCCGTGCTGCAGCGCATCAAGGAGAAC
AAAGGCGAGGAGCGGCTGCGCTCTACTATTGGGGTCGACGGTTCCGTCTACAAGAAACAC
CCCCATTTTGCCAAGCGTCTACATAAGACCGTGCGGCGGCTGGTGCCCGGCTGCGATGTC
CGCTTCCTCCGCTCCGAGGATGGCAGTGGCAAAGGTGCAGCCATGGTGACAGCAGTGGCT
TACCGGCTGGCCGATCAACACCGTGCCCGCCAGAAGACATTAGAGCATCTGCAGCTGAGC
CATGACCAGCTGCTGGAGGTCAAGAGGAGGATGAAGGTAGAAATGGAGCGAGGTCTGAGC
AAGGAGACTCATGCCAGTGCCCCCGTCAAGATGCTGCCCACCTACGTGTGTGCTACCCCG
GACGGCACAGAGAAAGGGGACTTCTTGGCCTTGGACCTTGGAGGAACAAATTTCCGGGTC
CTGCTGGTCCGTGTTCGGAATGGGAAGTGGGGTGGAGTGGAGATGCACAACAAGATCTAC
GCCATCCCGCAGGAGGTCATGCACGGCACCGGGGACGAGCTCTTTGACCACATTGTCCAG
TGCATCGCGGACTTCCTCGAGTACATGGGCATGAAGGGCGTGTCCCTGCCTCTGGGTTTT
ACCTTCTCCTTCCCCTGCCAGCAGAACAGCCTGGACGAGAGCATCCTCCTCAAGTGGACA
AAAGGCTTCAAGGCATCTGGCTGCGAGGGCGAGGACGTGGTGACCCTGCTGAAGGAAGCG
ATCCACCGGCGAGAGGAGTTTGACCTGGATGTGGTTGCTGTGGTGAACGACACAGTCGGA
ACTATGATGACCTGTGGCTTTGAAGACCCTCACTGTGAAGTTGGCCTCATTGTTGGCACG
GGCAGCAATGCCTGCTACATGGAGGAGATGCGCAACGTGGAACTGGTGGAAGGAGAAGAG
GGGCGGATGTGTGTGAACATGGAATGGGGGGCCTTCGGGGACAATGGATGCCTAGATGAC
TTCCGCACAGAATTTGATGTGGCTGTGGATGAGCTTTCACTCAACCCCGGCAAGCAGAGG
TTCGAGAAAATGATCAGTGGAATGTACCTGGGTGAGATTGTCCGTAACATTCTCATCGAT
TTCACCAAGCGTGGACTACTCTTCCGAGGCCGCATCTCAGAGCGGCTCAAGACAAGGGGC
ATCTTTGAAACCAAGTTCTTGTCTCAGATTGAGAGTGACTGCCTGGCCCTGCTGCAAGTC
CGAGCCACCCTGCAACACTTAGGGCTTGAGAGCACCTGTGACGACAGCATCATTGTTAAG
GAGGTGTGCACTGTGGTGGCCCGGCGGGCAGCCCAGCTCTGTGGCGCAGGCATGGCCGCT
GTGGTGGACAGGATACGAGAAAACCGTGGGCTGGACGCTCTCAAAGTGACAGTGGGTGTG
GATGGGACCCTCTACAAGCTACATCCTCACTTTGCCAAAGTCATGCATGAGACAGTGAAG
GACCTGGCTCCGAAATGTGATGTGTCTTTCCTGCAGTCAGAGGATGGCAGCGGGAAGGGG
GCGGCGCTCATCACTGCTGTGGCCTGCCGCATCCGTGAGGCTGGACAGCGATAG

# Metabolic_Enzyme_16_GenBank_ID_Gene:
Z46376

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_16_Locus:
2p13

# Metabolic_Enzyme_16_SNPs:
rs2229629; rs3732299; rs28363029; rs28363015; rs2306808; rs2229626; rs10194657; rs2229622; rs28363033; rs28363014; rs943; rs656489; rs9679561; rs3832165; rs3732298; rs3732295; rs3821305; rs3732296; rs28363066; rs1061314; rs28384370; rs28362959; rs28363067; rs28384369; rs651071; rs2279429; rs1545522; rs681900; rs923273; rs1545523; rs1872837; rs3771755; rs4853066; rs1565064; rs3771782; rs3771772; rs3821307; rs11893422; rs680545; rs6732614; rs3771754; rs678350; rs11903758; rs11694331; rs694644; rs6754642; rs1032206; rs1869339; rs3771798; rs11688312; rs3771770; rs2171385; rs1487371; rs13395967; rs685363; rs6735303; rs3771781; rs4853069; rs3771752; rs6730141; rs2306806; rs3771756; rs4241264; rs10153633; rs3771771; rs3771763; rs3816456; rs17010492; rs11688305; rs13384240; rs3755454; rs3821310; rs11675401; rs2279428; rs6749471; rs10496195; rs28363012; rs3771751; rs3732300; rs28362967; rs4852347; rs3771786; rs3771759; rs3755453; rs6722578; rs4853067; rs28362977; rs3771768; rs3771773; rs28362973; rs3771783; rs3771760; rs3821309; rs1869340; rs4853064; rs3771758; rs3771769; rs11888976; rs3755452; rs2068358; rs10153634; rs17741356; rs3732301; rs4853068; rs3771753; rs6752205; rs11675438; rs4853065; rs6720940; rs2306805; rs3771790; rs3771766; rs17010467; rs28363062; rs13382443; rs3771761; rs28362980; rs28362969; rs3771775; rs10183051; rs3821311; rs3771762; rs604207; rs2123615; rs28362972; rs3755450; rs1807090; rs7602790; rs602898; rs634849; rs28363004; rs3771792; rs13394603; rs17010460; rs675611; rs28363048; rs28746193; rs28363047; rs28362983; rs28363042; rs28363035; rs28363055; rs28362999; rs28363003; rs3771788; rs28363044; rs3771793; rs5832141; rs28363060; rs28362996; rs3821308; rs11680091; rs2901626; rs3771778; rs11126442; rs28363053; rs28363021; rs17010436; rs28363011; rs11675530; rs28363054; rs28362979; rs28363008; rs28362968; rs6709975; rs28362997; rs13389855; rs28363032; rs2422043; rs17010464; rs842667; rs28363028; rs28362993; rs3078015; rs28362965; rs3755451; rs28363040; rs28362981; rs604112; rs3771784; rs28362964; rs13405909; rs663504; rs28363037; rs1565063; rs603743; rs6756096; rs13398307; rs28363027; rs28363049; rs13397480; rs11894886; rs17010504; rs28363031; rs28362987; rs28362990; rs4852348; rs28363023; rs3771767; rs2279427; rs3771785; rs28746191; rs680015; rs35902493; rs28362986; rs3771791; rs28363000; rs28363041; rs17847166; rs1386536; rs3821306; rs7572459; rs10496196; rs10496197; rs28363016; rs28363065; rs17847161; rs35677390; rs36066402; rs28363057; rs35396457; rs28363006; rs17847160; rs28363005; rs28363051; rs11556194; rs3202369; rs3732302; rs13429546; rs34573284; rs3832164; rs28384371; rs28362960; rs6741953; rs11556193; rs28384372; rs28384368; rs10451660; rs28362991; rs6755864; rs28363026; rs28363056; rs34315149; rs35716613; rs11689606; rs28363061; rs2029236; rs28362988; rs28363050; rs28363043; rs684491; rs28363034; rs2901627; rs11295383; rs5832143; rs618023; rs28362963; rs28362995; rs28363059; rs35137588; rs34780455; rs13432314; rs28363022; rs11450211; rs34286902; rs35601612; rs2422045; rs28362971; rs3771776; rs13395815; rs34063910; rs636903; rs28362978; rs6707123; rs5832142; rs6743207; rs35570397; rs13386610; rs676065; rs28362992; rs28363007; rs34662031; rs3836190; rs17847145; rs28362962; rs28363058; rs28363039; rs35888944; rs13387771; rs13004379; rs28362974; rs28362984; rs3836189; rs28362989; rs600578; rs35586432; rs28363064; rs10675736; rs6708938; rs17847149; rs35315423; rs10175889; rs28363019; rs3077985; rs35276905; rs28363036; rs35227945; rs3771787; rs35771648; rs7604247; rs2422046; rs3771774; rs11459447; rs28567425; rs35641789; rs11369279; rs6753090; rs28362961; rs11688513; rs11300678; rs28363018; rs10169547; rs28363024; rs34066885; rs6728248; rs7596751; rs28363010; rs28363002; rs36226712; rs28363052; rs34552028; rs2901628; rs28362976; rs3836188; rs28363046; rs7557784; rs17847165; rs35591732; rs28363063; rs28363020; rs28363025; rs28362985; rs28363009; rs34553329; rs35969102; rs28746192; rs7596131; rs10688878; rs35605685; rs2422044; rs34611487; rs28363017; rs3836187; rs28362982; rs17847158; rs36027258; rs5832144; rs28363001; rs34885061; rs41498345; rs28362994; rs34743801; rs34980367; rs636472; rs34106533; rs28969559; rs11308687; rs28363013; rs28363045; rs28363038; rs28362966; rs34842573; rs13020188; rs28362970; rs3771779; rs35454195; rs3771780; rs28746194; rs3771796; rs7600390; rs34021969; rs13411123; rs28362975; rs28362998; rs28363030; rs13013519; rs10865403; rs28384373; rs7424799; rs35575305; rs608112; rs659635; rs619850; rs3887287; rs35614058; rs35250889; rs10865404; rs11892954; rs12151815; rs1565068; rs17678046; rs17678088; rs2087173; rs2129603; rs34610149; rs4241265; rs4443023; rs4443024; rs4549114; rs4853059; rs5020284; rs628983; rs6546935; rs657209; rs670083; rs6730659; rs6758134; rs748357; rs7571422; rs7596427; rs7597871

# Metabolic_Enzyme_16_General_References:
8786021; 8250948; 7518342; 7883120; 7883122; 7883123

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5314

# Metabolic_Enzyme_17_Name:
Soluble calcium-activated nucleotidase 1

# Metabolic_Enzyme_17_Synonyms:
SCAN-1; Apyrase homolog; Putative NF-kappa-B-activating protein 107; Putative MAPK-activating protein PM09

# Metabolic_Enzyme_17_Gene_Name:
CANT1

# Metabolic_Enzyme_17_Protein_Sequence:
>Soluble calciumactivated nucleotidase 1
MPVQLSEHPEWNESMHSLRISVGGLPVLASMTKAADPRFRPRWKVILTFFVGAAILWLLC
SHRPAPGRPPTHNAHNWRLGQAPANWYNDTYPLSPPQRTPAGIRYRIAVIADLDTESRAQ
EENTWFSYLKKGYLTLSDSGDKVAVEWDKDHGVLESHLAEKGRGMELSDLIVFNGKLYSV
DDRTGVVYQIEGSKAVPWVILSDGDGTVEKGFKAEWLAVKDERLYVGGLGKEWTTTTGDV
VNENPEWVKVVGYKGSVDHENWVSNYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPR
RASQERYSEKDDERKGANLLLSASPDFGDIAVSHVGAVVPTHGFSSFKFIPNTDDQIIVA
LKSEEDSGRVASYIMAFTLDGRFLLPETKIGSVKYEGIEFI

# Metabolic_Enzyme_17_Number_of_Residues:
401

# Metabolic_Enzyme_17_Molecular_Weight:
44840

# Metabolic_Enzyme_17_Theoretical_pI:
5.98

# Metabolic_Enzyme_17_GO_Classification:
Not Available

# Metabolic_Enzyme_17_General_Function:
Not Available

# Metabolic_Enzyme_17_Specific_Function:
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP

# Metabolic_Enzyme_17_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_17_Reaction:
A nucleoside diphosphate + H2O = a nucleotide + phosphate

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF06079:Apyrase

# Metabolic_Enzyme_17_Signals:
None

# Metabolic_Enzyme_17_Transmembrane_Regions:
45-62

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 3.6.1.6

# Metabolic_Enzyme_17_GenBank_ID_Protein:
22218108

# Metabolic_Enzyme_17_SwissProt_ID:
CANT1_HUMAN (Q8WVQ1)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
CANT1

# Metabolic_Enzyme_17_Geneatlas_id:
CANT1

# Metabolic_Enzyme_17_hgnc_id:
HGNC:19721

# Metabolic_Enzyme_17_PDB_ID:
1S1D

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Intracytoplasmic membrane; single-pass type II membrane protein. Processed form:Secreted protein

# Metabolic_Enzyme_17_Gene_Sequence:
>1116 bp
ATGACCAAGGCCGCGGACCCCCGCTTCCGCCCCCGCTGGAAGGTGATCCTGACGTTCTTT
GTGGGTGCTGCCATCCTCTGGCTGCTCTGCTCCCACCGCCCGGCCCCCGGCAGGCCCCCC
ACCCACAATGCACACAACTGGAGGCTCGGCCAGGCGCCCGCCAACTGGTACAATGACACC
TACCCCCTGTCTCCCCCACAAAGGACACCGGCTGGGATTCGGTATCGAATCGCAGTTATC
GCAGACCTGGACACAGAGTCAAGGGCCCAAGAGGAAAACACCTGGTTCAGTTACCTGAAA
AAGGGCTACCTGACCCTGTCAGACAGTGGGGACAAGGTGGCCGTGGAATGGGACAAAGAC
CATGGGGTCCTGGAGTCCCACCTGGCGGAGAAGGGGAGAGGCATGGAGCTATCCGACCTG
ATTGTTTTCAATGGGAAACTCTACTCCGTGGATGACCGGACGGGGGTCGTCTACCAGATC
GAAGGCAGCAAAGCCGTGCCCTGGGTGATTCTGTCCGACGGCGACGGCACCGTGGAGAAA
GGCTTCAAGGCCGAATGGCTGGCAGTGAAGGACGAGCGTCTGTACGTGGGCGGCCTGGGC
AAGGAGTGGACGACCACTACGGGTGATGTGGTGAACGAGAACCCGGAGTGGGTGAAGGTG
GTGGGCTACAAGGGCAGCGTGGACCACGAGAACTGGGTGTCCAACTACAACGCCCTGCGG
GCTGCTGCCGGCATCCAGCCGCCAGGCTACCTCATCCATGAGTCTGCCTGCTGGAGTGAC
ACGCTGCAGCGCTGGTTCTTCCTGCCGCGCCGCGCCAGCCAGGAGCGCTACAGCGAGAAG
GACGACGAGCGCAAGGGCGCCAACCTGCTGCTGAGCGCCTCCCCTGACTTCGGCGACATC
GCTGTGAGCCACGTCGGGGCGGTGGTCCCCACTCACGGCTTCTCGTCCTTCAAGTTCATC
CCCAACACCGACGACCAGATCATTGTGGCCCTCAAATCCGAGGAGGACAGCGGCAGAGTC
GCCTCCTACATCATGGCCTTCACGCTGGACGGGCGCTTCCTGTTGCCGGAGACCAAGATC
GGAAGCGTGAAATACGAAGGCATCGAGTTCATTTAA

# Metabolic_Enzyme_17_GenBank_ID_Gene:
AF328554

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_17_Locus:
17q25.3

# Metabolic_Enzyme_17_SNPs:
rs8077024; rs35290882; rs35324359; rs2377301; rs9916285; rs3744171; rs4789903; rs9896857; rs4789848; rs12450407; rs7214331; rs12450128; rs4789847; rs4861; rs11891; rs17739056; rs12452918; rs3744173; rs12949479; rs16971940; rs8079368; rs4789904; rs9904301; rs3744170; rs12452876; rs3744168; rs9915230; rs12452980; rs12451303; rs11546278; rs34082669; rs9903215; rs3803781; rs1127654; rs34461224; rs2377010; rs5017245; rs34435616; rs5017244; rs35308608; rs35755919; rs7219932; rs28627413; rs8078860; rs34996994; rs12936828; rs9899883; rs35356398; rs34938499; rs5017243; rs34572362; rs14791; rs4789849; rs34891215; rs2377009; rs34097366; rs35738150; rs5017242; rs3038740; rs35518955; rs9891726; rs3744169; rs12939358; rs12939350; rs12939399; rs4497730; rs6501274; rs9914188

# Metabolic_Enzyme_17_General_References:
12234496; 12761501; 12167635

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5337

# Metabolic_Enzyme_18_Name:
Uridine-cytidine kinase 1

# Metabolic_Enzyme_18_Synonyms:
UCK 1; Uridine monophosphokinase 1; Cytidine monophosphokinase 1

# Metabolic_Enzyme_18_Gene_Name:
UCK1

# Metabolic_Enzyme_18_Protein_Sequence:
>Uridinecytidine kinase 1
MASAGGEDCESPAPEADRPHQRPFLIGVSGGTASGKSTVCEKIMELLGQNEVEQRQRKVV
ILSQDRFYKVLTAEQKAKALKGQYNFDHPDAFDNDLMHRTLKNIVEGKTVEVPTYDFVTH
SRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDVRRGRDL
EQILTQYTTFVKPAFEEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDILNGDICKWHR
GGSNGRSYKRTFSEPGDHPGMLTSGKRSHLESSSRPH

# Metabolic_Enzyme_18_Number_of_Residues:
277

# Metabolic_Enzyme_18_Molecular_Weight:
31435

# Metabolic_Enzyme_18_Theoretical_pI:
7.33

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleoside kinase activity
Function:  uridine kinase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_18_Specific_Function:
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, 4-N-acetylcytidine, 4-N- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and 4-N-anisoylcytidine

# Metabolic_Enzyme_18_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_18_Reaction:
ATP + uridine = ADP + UMP

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF00485:PRK

# Metabolic_Enzyme_18_Signals:
None

# Metabolic_Enzyme_18_Transmembrane_Regions:
None

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 2.7.1.48

# Metabolic_Enzyme_18_GenBank_ID_Protein:
13506765

# Metabolic_Enzyme_18_SwissProt_ID:
UCK1_HUMAN (Q9HA47)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
UCK1

# Metabolic_Enzyme_18_Geneatlas_id:
UCK1

# Metabolic_Enzyme_18_hgnc_id:
HGNC:14859

# Metabolic_Enzyme_18_PDB_ID:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Not Available

# Metabolic_Enzyme_18_Gene_Sequence:
>834 bp
ATGGCTTCGGCGGGAGGCGAAGACTGCGAGAGCCCCGCGCCGGAGGCCGACCGTCCGCAC
CAGCGGCCCTTCCTGATAGGGGTGAGCGGCGGCACTGCCAGCGGGAAGTCGACCGTGTGT
GAGAAGATCATGGAGTTGCTGGGACAGAACGAGGTGGAACAGCGGCAGCGGAAGGTGGTC
ATCCTGAGCCAGGACAGGTTCTACAAGGTCCTGACGGCAGAGCAGAAGGCCAAGGCCTTG
AAAGGACAGTACAATTTTGACCATCCAGATGCCTTTGATAATGATTTGATGCACAGGACT
CTGAAGAACATCGTGGAGGGCAAAACGGTGGAGGTGCCGACCTATGATTTTGTGACACAC
TCAAGGTTACCAGAGACCACGGTGGTCTACCCTGCGGACGTGGTTCTGTTTGAGGGCATC
TTGGTGTTCTACAGCCAGGAGATCCGGGACATGTTCCACCTGCGCCTCTTCGTGGACACC
GACTCCGACGTCAGGCTGTCTCGAAGAGTTCTCCGGGACGTGCGCCGAGGGAGGGACCTG
GAGCAGATTCTGACGCAGTACACCACCTTCGTGAAGCCGGCCTTCGAGGAGTTCTGCCTG
CCGACAAAGAAGTATGCCGATGTGATCATCCCGCGAGGAGTGGACAATATGGTTGCCATC
AACCTGATCGTGCAGCACATCCAGGACATTCTGAATGGTGACATCTGCAAATGGCACCGA
GGAGGGTCCAATGGGCGGAGCTACAAGCGGACCTTTTCTGAGCCAGGGGACCACCCTGGG
ATGCTGACCTCTGGCAAACGGTCACATTTGGAGTCCAGCAGCAGACCCCACTGA

# Metabolic_Enzyme_18_GenBank_ID_Gene:
AF237290

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_18_Locus:
9q34.13

# Metabolic_Enzyme_18_SNPs:
rs2296957; rs35991434; rs6597502; rs4740260; rs10793886; rs10793887; rs6597503; rs7859459; rs3808830; rs9785228; rs3904961; rs12682945; rs35345663; rs10609062; rs34523479; rs7869614; rs12377531; rs36042195; rs36102623; rs34811006; rs34625466; rs11440136; rs5900943; rs35542333; rs7862845; rs4292738; rs35582001; rs7040906; rs12684413; rs10257; rs1052561; rs10698; rs10793885; rs11005; rs11023; rs11243406; rs11243408; rs12003400; rs12115566; rs12551562; rs14188; rs1547768; rs17537644; rs2010635; rs2277152; rs2277153; rs2282010; rs2282011; rs2296956; rs3183977; rs34492185; rs34954751; rs3739495; rs3824395; rs3904960; rs4113141; rs4740165; rs4740257; rs4740259; rs4740263; rs7849433; rs7867616; rs7868519; rs7870715; rs946713

# Metabolic_Enzyme_18_General_References:
11306702

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5668

# Metabolic_Enzyme_19_Name:
Inosine triphosphate pyrophosphatase

# Metabolic_Enzyme_19_Synonyms:
ITPase; Inosine triphosphatase; Putative oncogene protein hlc14-06-p

# Metabolic_Enzyme_19_Gene_Name:
ITPA

# Metabolic_Enzyme_19_Protein_Sequence:
>Inosine triphosphate pyrophosphatase
MAASLVGKKIVFVTGNAKKLEEVVQILGDKFPCTLVAQKIDLPEYQGEPDEISIQKCQEA
VRQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLAGFEDKSAYALCTFAL
STGDPSQPVRLFRGRTSGRIVAPRGCQDFGWDPCFQPDGYEQTYAEMPKAEKNAVSHRFR
ALLELQEYFGSLAA

# Metabolic_Enzyme_19_Number_of_Residues:
194

# Metabolic_Enzyme_19_Molecular_Weight:
21446

# Metabolic_Enzyme_19_Theoretical_pI:
5.34

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_19_Specific_Function:
Hydrolyzes ITP and dITP to their respective monophosphate derivatives. Xanthosine 5'-triphosphate (XTP) is also a potential substrate. May be the major enzyme responsible for regulating ITP concentration in cells

# Metabolic_Enzyme_19_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_19_Reaction:
A nucleoside triphosphate + H2O = a nucleotide + diphosphate

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF01725:Ham1p_like

# Metabolic_Enzyme_19_Signals:
None

# Metabolic_Enzyme_19_Transmembrane_Regions:
None

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 3.6.1.19

# Metabolic_Enzyme_19_GenBank_ID_Protein:
13398328

# Metabolic_Enzyme_19_SwissProt_ID:
ITPA_HUMAN (Q9BY32)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
ITPA

# Metabolic_Enzyme_19_Geneatlas_id:
ITPA

# Metabolic_Enzyme_19_hgnc_id:
HGNC:6176

# Metabolic_Enzyme_19_PDB_ID:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_19_Gene_Sequence:
>585 bp
ATGGCGGCCTCATTGGTGGGGAAGAAGATCGTGTTTGTAACGGGGAACGCCAAGAAGCTG
GAGGAGGTCGTTCAGATTCTAGGAGATAAGTTTCCACGCACTTTGGTGGCACAGAAAATT
GACCTGCCGGAGTACCAGGGGGAGCCGGATGAGATTTCCATACAGAAATGTCAGGAGGCA
GTTCGCCAGGTACAGGGGCCCGTGCTGGTTGAGGACACTTGTCTGTGCTTCAATGCCCTT
GGAGGGCTCCCCGGCCCCTACATAAAGTGGTTTCTGGAGAAGTTAAAGCCTGAAGGTCTC
CACCAGCTCCTGGCCGGGTTCGAGGACAAGTCAGCCTATGCGCTCTGCACGTTTGCACTC
AGCACCGGGGACCCAAGCCAGCCCGTGCGCCTGTTCAGGGGCCGGACCTCGGGCCGGATC
GTGGCACCCAGAGGCTGCCAGGACTTTGGCTGGGACCCCTGCTTTCAGCCTGATGGATAT
GAGCAGACGTACGCAGAGATGCCTAAGGCGGAGAAGAACGCTGTCTCCCATCGCTTCCGG
GCCCTGCTGGAGCTGCAGGAGTACTTTGGCAGTTTGGCAGCTTGA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
AF219116

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_19_Locus:
20p

# Metabolic_Enzyme_19_SNPs:
rs41320251; rs9101; rs8362; rs13830; rs1043688; rs6051646; rs4815576; rs6139034; rs6037506; rs6107257; rs2236206; rs6084307; rs6084305; rs11087571; rs6037502; rs6139033; rs6084304; rs6139036; rs6037501; rs6107258; rs6139035; rs8115328; rs6084301; rs6084308; rs7262711; rs2422863; rs6084306; rs2422862; rs11087570; rs6084303; rs6051648; rs4813632; rs6037504; rs11906193; rs12625773; rs4815577; rs6084302; rs8114386; rs2422860; rs6051650; rs7270101; rs6037503; rs6076494; rs6051644; rs6076491; rs6139031; rs6037500; rs34982958; rs1043959; rs11480889; rs8122216; rs35820452; rs35991941; rs35671839; rs6115816; rs6076493; rs11905115; rs11473134; rs6051653; rs35249381; rs13040402; rs33944702; rs6076495; rs6115819; rs7270134; rs6084300; rs35002933; rs28479679; rs6115815; rs6133021; rs10598340; rs6051647; rs6076496; rs35141053; rs6115814; rs6115818; rs6139032; rs11481198; rs2422861; rs33961294; rs34376287; rs12480483; rs6115817; rs34475210; rs35568595; rs4447662; rs34868586; rs6084309; rs10537787; rs11471713; rs11469873; rs6051649; rs6076492; rs8113964; rs8116264; rs9680022; rs6037505; rs6051651; rs35127071; rs11479168; rs13043233; rs34929648; rs6051645; rs35045261; rs4510299; rs10048856; rs11697114; rs11697186; rs11699145; rs11907085; rs2144771; rs2295553; rs34224785; rs3810559; rs3810560; rs4630837; rs6051639; rs6051643; rs6051654; rs6051655; rs6051657; rs6051658; rs6084312; rs6115821; rs6139039; rs7262083; rs7262506; rs731282; rs7344681; rs8115151; rs8117254

# Metabolic_Enzyme_19_General_References:
11278832; 11780052; 12384777; 12436200

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
5442

# Metabolic_Enzyme_20_Name:
Glucokinase

# Metabolic_Enzyme_20_Synonyms:
Hexokinase-4; Hexokinase type IV; HK IV; HK4; Hexokinase-D

# Metabolic_Enzyme_20_Gene_Name:
GCK

# Metabolic_Enzyme_20_Protein_Sequence:
>Glucokinase
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ

# Metabolic_Enzyme_20_Number_of_Residues:
465

# Metabolic_Enzyme_20_Molecular_Weight:
52192

# Metabolic_Enzyme_20_Theoretical_pI:
4.85

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  hexokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_20_General_Function:
Not Available

# Metabolic_Enzyme_20_Specific_Function:
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage

# Metabolic_Enzyme_20_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00052  Galactose metabolism;
 map00500  Starch and sucrose metabolism;
 map00521  Streptomycin biosynthesis

# Metabolic_Enzyme_20_Reaction:
ATP + D-glucose = ADP + D-glucose 6-phosphate

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00349:Hexokinase_1;
PF03727:Hexokinase_2

# Metabolic_Enzyme_20_Signals:
None

# Metabolic_Enzyme_20_Transmembrane_Regions:
None

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 2.7.1.2

# Metabolic_Enzyme_20_GenBank_ID_Protein:
179427

# Metabolic_Enzyme_20_SwissProt_ID:
HXK4_HUMAN (P35557)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
GCK

# Metabolic_Enzyme_20_Geneatlas_id:
GCK

# Metabolic_Enzyme_20_hgnc_id:
HGNC:4195

# Metabolic_Enzyme_20_PDB_ID:
1V4T

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Not Available

# Metabolic_Enzyme_20_Gene_Sequence:
>1398 bp
ATGCTGGACGACAGAGCCAGGATGGAGGCCGCCAAGAAGGAGAAGGTAGAGCAGATCCTG
GCAGAGTTCCAGCTGCAGGAGGAGGACCTGAAGAAGGTGATGAGACGGATGCAGAAGGAG
ATGGACCGCGGCCTGAGGCTGGAGACCCATGAAGAGGCCAGTGTGAAGATGCTGCCCACC
TACGTGCGCTCCACCCCAGAAGGCTCAGAAGTCGGGGACTTCCTCTCCCTGGACCTGGGT
GGCACTAACTTCAGGGTGATGCTGGTGAAGGTGGGAGAAGGTGAGGAGGGGCAGTGGAGC
GTGAAGACCAAACACCAGATGTACTCCATCCCCGAGGACGCCATGACCGGCACTGCTGAG
ATGCTCTTCGACTACATCTCTGAGTGCATCTCCGACTTCCTGGACAAGCATCAGATGAAA
CACAAGAAGCTGCCCCTGGGCTTCACCTTCTCCTTTCCTGTGAGGCACGAAGACATCGAT
AAGGGCATCCTTCTCAACTGGACCAAGGGCTTCAAGGCCTCAGGAGCAGAAGGGAACAAT
GTCGTGGGGCTTCTGCGAGACGCTATCAAACGGAGAGGGGACTTTGAAATGGATGTGGTG
GCAATGGTGAATGACACGGTGGCCACGATGATCTCCTGCTACTACGAAGACCATCAGTGC
GAGGTCGGCATGATCGTGGGCACGGGCTGCAATGCCTGCTACATGGAGGAGATGCAGAAT
GTGGAGCTGGTGGAGGGGGACGAGGGCCGCATGTGCGTCAATACCGAGTGGGGCGCCTTC
GGGGACTCCGGCGAGCTGGACGAGTTCCTGCTGGAGTATGACCGCCTGGTGGACGAGAGC
TCTGCAAACCCCGGTCAGCAGCTGTATGAGAAGCTCATAGGTGGCAAGTACATGGGCGAG
CTGGTGCGGCTTGTGCTGCTCAGGCTCGTGGACGAAAACCTGCTCTTCCACGGGGAGGCC
TCCGAGCAGCTGCGCACACGCGGAGCCTTCGAGACGCGCTTCGTGTCGCAGGTGGAGAGC
GACACGGGCGACCGCAAGCAGATCTACAACATCCTGAGCACGCTGGGGCTGCGACCCTCG
ACCACCGACTGCGACATCGTGCGCCGCGCCTGCGAGAGCGTGTCTACGCGCGCTGCGCAC
ATGTGCTCGGCGGGGCTGGCGGGCGTCATCAACCGCATGCGCGAGAGCCGCAGCGAGGAC
GTAATGCGCATCACTGTGGGCGTGGATGGCTCCGTGTACAAGCTGCACCCCAGCTTCAAG
GAGCGGTTCCATGCCAGCGTGCGCAGGCTGACGCCCAGCTGCGAGATCACCTTCATCGAG
TCGGAGGAGGGCAGTGGCCGGGGCGCGGCCCTGGTCTCGGCGGTGGCCTGTAAGAAGGCC
TGTATGCTGGGCCAGTGA

# Metabolic_Enzyme_20_GenBank_ID_Gene:
M88011

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_20_Locus:
7p15.3-p15.1

# Metabolic_Enzyme_20_SNPs:
rs2908275; rs2908276; rs13306390; rs13306391; rs2284776; rs2268572; rs2908290; rs741038; rs758989; rs2908289; rs2070971; rs2908296; rs758985; rs2268576; rs2268574; rs2300586; rs1990458; rs2908297; rs1303722; rs3808319; rs2300584; rs2971672; rs2284777; rs12540369; rs2268575; rs2908298; rs2010825; rs12535229; rs7793213; rs2908292; rs2971677; rs3808323; rs12534623; rs2971679; rs2268570; rs2908274; rs730497; rs11766576; rs3808322; rs12673242; rs2971678; rs17832252; rs2268573; rs2971674; rs2971671; rs4724290; rs2041547; rs758987; rs13239289; rs2268569; rs3808320; rs17172566; rs10246064; rs758988; rs16881016; rs2300587; rs3808321; rs887688; rs2284773; rs758986; rs887686; rs2244164; rs10259649; rs12702069; rs2284769; rs6952751; rs11768239; rs2080033; rs2971676; rs887687; rs2971675; rs2908293; rs6945550; rs13306387; rs2908291; rs12702068; rs12534104; rs2215644; rs1799884; rs1476891; rs2908277; rs12702070; rs34389297; rs13306389; rs35548117; rs34322372; rs13306388; rs13306393; rs41282709; rs35140467; rs13306392; rs35521280; rs34255297; rs28639899; rs741039; rs5883891; rs2284771; rs34710012; rs34691097; rs2971670; rs34288160; rs34574619; rs34807880; rs3216596; rs34265547; rs34672149; rs34973571; rs35368425; rs13227198; rs36094778; rs35276355; rs28491181; rs34859037; rs34947625; rs5883890; rs35079658; rs34780996; rs35606092; rs34124036; rs2971680; rs3065183; rs41282712; rs35786405; rs4724291; rs3840676; rs34675661; rs2284778; rs11447509; rs2284779; rs2268577; rs10680351; rs1303721; rs2908294; rs34114506; rs1799831; rs36084943; rs2908295; rs11974018; rs34380942; rs36118223; rs35568119; rs2284772; rs34185745; rs11772934; rs35262363; rs11412934; rs35723429; rs2284774; rs41282715; rs36193808; rs11287012; rs6971410; rs41314139; rs2284775; rs35688609; rs13239987; rs34178750; rs28684786; rs35620913; rs35907141; rs34976798; rs34359315; rs3779606; rs13306394; rs3840677; rs1076439; rs36205687; rs35670475; rs11372006; rs36205684; rs2971681; rs36205686; rs36205690; rs36205688; rs1008384; rs12669054; rs17135975; rs17136076; rs17172591; rs17769733; rs2080032; rs2908278; rs2908286; rs2971669; rs3757838; rs3757840; rs4397301; rs4607517; rs6953355; rs6975024; rs735670; rs737525; rs741033; rs741034; rs741035; rs741036; rs741037; rs758983; rs882019; rs882020; rs882021

# Metabolic_Enzyme_20_General_References:
1354840; 1871135; 1511800; 1612194; 1502186; 1464666; 8194664; 1303265; 8454109; 8495817; 8325892; 8446612; 8168652; 9049484; 9662401; 9435328; 10588527; 11106831; 11372010

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
5345

# Metabolic_Enzyme_21_Name:
Nucleoside diphosphate kinase 3

# Metabolic_Enzyme_21_Synonyms:
NDK 3; NDP kinase 3; Nucleoside diphosphate kinase C; NDPKC; nm23-H3; DR-nm23

# Metabolic_Enzyme_21_Gene_Name:
NME3

# Metabolic_Enzyme_21_Protein_Sequence:
>Nucleoside diphosphate kinase 3
MICLVLTIFANLFPAACTGAHERTFLAVKPDGVQRRLVGEIVRRFERKGFKLVALKLVQA
SEELLREHYAELRERPFYGRLVKYMASGPVVAMVWQGLDVVRTSRALIGATNPADAPPGT
IRGDFCIEVGKNLIHGSDSVESARREIALWFRADELLCWEDSAGHWLYE

# Metabolic_Enzyme_21_Number_of_Residues:
169

# Metabolic_Enzyme_21_Molecular_Weight:
19015

# Metabolic_Enzyme_21_Theoretical_pI:
7.97

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  nucleoside diphosphate kinase activity
 ||
>>>
Process:  CTP biosynthesis
Process:  nucleoside triphosphate metabolism
Process:  nucleoside triphosphate biosynthesis
Process:  ribonucleoside triphosphate biosynthesis
Process:  pyrimidine ribonucleoside triphosphate biosynthesis
Process:  UTP biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside triphosphate biosynthesis
Process:  purine ribonucleoside triphosphate biosynthesis
Process:  GTP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_21_Specific_Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis

# Metabolic_Enzyme_21_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_21_Reaction:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF00334:NDK

# Metabolic_Enzyme_21_Signals:
1-19

# Metabolic_Enzyme_21_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 2.7.4.6

# Metabolic_Enzyme_21_GenBank_ID_Protein:
1051256

# Metabolic_Enzyme_21_SwissProt_ID:
NDK3_HUMAN (Q13232)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
NME3

# Metabolic_Enzyme_21_Geneatlas_id:
NME3

# Metabolic_Enzyme_21_hgnc_id:
HGNC:7851

# Metabolic_Enzyme_21_PDB_ID:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Not Available

# Metabolic_Enzyme_21_Gene_Sequence:
>507 bp
ATGATCTGCCTGGTGCTGACCATCTTCGCTAACCTCTTCCCCGCGGCCTGCACCGGCGCA
CACGAACGCACCTTCCTGGCCGTGAAGCCGGACGGCGTGCAGCGGCGGCTGGTGGGCGAG
ATTGTGCGGCGCTTCGAGAGGAAGGGCTTCAAGTTGGTGGCGCTGAAGCTGGTGCAGTCC
TCCGAGGAGCTGCTGCGTGAGCACTACGCCGAGCTGCGTGAACGCCCGTTCTACGGCCGC
CTTGTCAAGTATATGGCCTCCGGGCCGGTGGTGGCCATGGTTTGGCAGGGGCTGGACGTG
GTGCGCACCTCGCGGGCGCTCATCGGAGCCACGAACCCGGCCGACGCCCCGCCCGGCACC
ATCCGCGGGGATTTCTGCATCGAGGTTGGCAACCTGATTCACGGCAGCGACTCGGTGGAG
AGTGCCCGCCGCGAGATCGCTCTCTGGTTCCGCGCAGACGAGCTCCTCTGCTGGGAGGAC
AGCGCTGGGCACTGGCTGTATGAGTAG

# Metabolic_Enzyme_21_GenBank_ID_Gene:
U29656

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_21_Locus:
16q13

# Metabolic_Enzyme_21_SNPs:
Not Available

# Metabolic_Enzyme_21_General_References:
7638209; 11157797

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
6037

# Metabolic_Enzyme_22_Name:
6-phosphofructokinase, muscle type

# Metabolic_Enzyme_22_Synonyms:
Phosphofructokinase 1; Phosphohexokinase; Phosphofructo-1-kinase isozyme A; PFK-A; Phosphofructokinase-M

# Metabolic_Enzyme_22_Gene_Name:
PFKM

# Metabolic_Enzyme_22_Protein_Sequence:
>6phosphofructokinase, muscle type
MTHEEHHAAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVD
GGDHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDG
SLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDS
ALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWE
EHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQ
RGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTK
AMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRPPVSKSGSHTVAVMNVGAPAAGMNAAVR
STVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQ
ISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSV
GADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPF
TIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLG
HMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVF
QPVAELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKRSGEAAV


# Metabolic_Enzyme_22_Number_of_Residues:
780

# Metabolic_Enzyme_22_Molecular_Weight:
85184

# Metabolic_Enzyme_22_Theoretical_pI:
8.07

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  phosphofructokinase activity
Function:  6-phosphofructokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  protein complex
Component:  6-phosphofructokinase complex
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_22_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_22_Specific_Function:
ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

# Metabolic_Enzyme_22_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00030  Pentose phosphate pathway;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism

# Metabolic_Enzyme_22_Reaction:
ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF00365:PFK

# Metabolic_Enzyme_22_Signals:
None

# Metabolic_Enzyme_22_Transmembrane_Regions:
None

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 2.7.1.11

# Metabolic_Enzyme_22_GenBank_ID_Protein:
1101758

# Metabolic_Enzyme_22_SwissProt_ID:
K6PF_HUMAN (P08237)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
PFKM

# Metabolic_Enzyme_22_Geneatlas_id:
PFKM

# Metabolic_Enzyme_22_hgnc_id:
HGNC:8877

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Not Available

# Metabolic_Enzyme_22_Gene_Sequence:
>2343 bp
ATGACCCATGAAGAGCACCATGCAGCCAAAACCCTGGGGATTGGCAAAGCCATTGCTGTC
TTAACCTCTGGTGGAGATGCCCAAGGTATGAATGCTGCTGTCAGGGCTGTGGTTCGAGTT
GGTATCTTCACCGGTGCCCGTGTCTTCTTTGTCCATGAGGGTTATCAAGGCCTGGTGGAT
GGTGGAGATCACATCAAGGAAGCCACCTGGGAGAGCGTTTCGATGATGCTTCAGCTGGGA
GGCACGGTGATTGGAAGTGCCCGGTGCAAGGACTTTCGGGAACGAGAAGGACGACTCCGA
GCTGCCTACAACCTGGTGAAGCGTGGGATCACCAATCTCTGTGTCATTGGGGGTGATGGC
AGCCTCACTGGGGCTGACACCTTCCGTTCTGAGTGGAGTGACTTGTTGAGTGACCTCCAG
AAAGCAGGTAAGATCACAGATGAGGAGGCTACGAAGTCCAGCTACCTGAACATTGTGGGC
CTGGTTGGGTCAATTGACAATGACTTCTGTGGCACTGATATGACCATTGGCACTGACTCT
GCCCTGCATCGGATCATGGAAATTGTAGATGCCATCACTACCACTGCCCAGAGCCACCAG
AGGACATTTGTGTTAGAAGTAATGGGCCGCCACTGTGGATACCTGGCCCTTGTCACCTCT
CTGTCCTGTGGGGCCGACTGGGTTTTTATTCCTGAATGTCCACCAGATGACGACTGGGAG
GAACACCTTTGTCGCCGACTCAGCGAGACAAGGACCCGTGGTTCTCGTCTCAACATCATC
ATTGTGGCTGAGGGTGCAATTGACAAGAATGGAAAACCAATCACCTCAGAAGACATCAAG
AATCTGGTGGTTAAGCGTCTGGGATATGACACCCGGGTTACTGTCTTGGGGCATGTGCAG
AGGGGTGGGACGCCATCAGCCTTTGACAGAATTCTGGGCAGCAGGATGGGTGTGGAAGCA
GTGATGGCACTTTTGGAGGGGACCCCAGATACCCCAGCCTGTGTAGTGAGCCTCTCTGGT
AACCAGGCTGTGCGCCTGCCCCTCATGGAATGTGTCCAGGTGACCAAAGATGTGACCAAG
GCCATGGATGAGAAGAAATTTGACGAAGCCCTGAAGCTGAGAGGCCGGAGCTTCATGAAC
AACTGGGAGGTGTACAAGCTTCTAGCTCATGTCAGACCCCCGGTATCTAAGAGTGGTTCG
CACACAGTGGCTGTGATGAACGTGGGGGCTCCGGCTGCAGGCATGAATGCTGCTGTTCGC
TCCACTGTGAGGATTGGCCTTATCCAGGGCAACCGAGTGCTCGTTGTCCATGATGGTTTC
GAGGGCCTGGCCAAGGGGCAGATAGAGGAAGCTGGCTGGAGCTATGTTGGGGGCTGGACT
GGCCAAGGTGGCTCTAAACTTGGGACTAAAAGGACTCTACCCAAGAAGAGCTTTGAACAG
ATCAGTGCCAATATAACTAAGTTTAACATTCAGGGCCTTGTCATCATTGGGGGCTTTGAG
GCTTACACAGGGGGCCTGGAACTGATGGAGGGCAGGAAGCAGTTTGATGAGCTCTGCATC
CCATTTGTGGTCATTCCTGCTACAGTCTCCAACAATGTCCCTGGCTCAGACTTCAGCGTT
GGGGCTGACACAGCACTCAATACTATCTGCACAACCTGTGACCGCATCAAGCAGTCAGCA
GCTGGCACCAAGCGTCGGGTGTTTATCATTGAGACTATGGGTGGCTACTGTGGCTACCTG
GCTACCATGGCTGGACTGGCAGCTGGGGCCGATGCTGCCTACATTTTTGAGGAGCCCTTC
ACCATTCGAGACCTGCAGGCAAATGTTGAACATCTGGTGCAAAAGATGAAAACAACTGTG
AAAAGGGGCTTGGTGTTAAGGAATGAAAAGTGCAATGAGAACTATACCACTGACTTCATT
TTCAACCTGTACTCTGAGGAGGGGAAGGGCATCTTCGACAGCAGGAAGAATGTGCTTGGT
CACATGCAGCAGGGTGGGAGCCCAACCCCATTTGATAGGAATTTTGCCACTAAGATGGGC
GCCAAGGCTATGAACTGGATGTCTGGGAAAATCAAAGAGAGTTACCGTAATGGGCGGATC
TTTGCCAATACTCCAGATTCGGGCTGTGTTCTGGGGATGCGTAAGAGGGCTCTGGTCTTC
CAACCAGTGGCTGAGCTGAAGGACCAGACAGATTTTGAGCATCGAATCCCCAAGGAACAG
TGGTGGCTGAAACTGAGGCCCATCCTCAAAATCCTAGCCAAGTACGAGATTGACTTGGAC
ACTTCAGACCATGCCCACCTGGAGCACATCACCCGGAAGCGGTCCGGGGAAGCTGCCGTC
TAA

# Metabolic_Enzyme_22_GenBank_ID_Gene:
M59741

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_22_Locus:
12q13.3

# Metabolic_Enzyme_22_SNPs:
rs2228500; rs8716; rs1049392; rs1859445; rs1476607; rs4760685; rs4075913; rs2286020; rs4760684; rs10875747; rs2286021; rs11168421; rs10082861; rs4141065; rs2269933; rs10875749; rs10875746; rs12304251; rs10219645; rs11168424; rs11168423; rs7484648; rs10875748; rs11168427; rs11830546; rs11168425; rs10219623; rs11168419; rs4760683; rs10875745; rs11168417; rs2269935; rs11168418; rs11168420; rs11552506; rs41291965; rs12828446; rs41291971; rs12826853; rs12317430; rs41290390; rs11552507; rs14683; rs3189641; rs8977; rs35847394; rs11374838; rs34737106; rs12817932; rs41291969; rs12826678; rs34747961; rs34241029; rs36015571; rs3989535; rs11168422; rs11609979; rs12826680; rs34700912; rs33914383; rs7978674; rs41291963; rs7301375; rs12831427; rs41291961; rs41291967; rs34996435; rs34207745; rs4075914; rs35651820; rs11835145; rs7133146; rs10219520; rs10783230; rs10875750; rs11168413; rs11168414; rs11168428; rs11608670; rs12297470; rs12310813; rs12422786; rs12579815; rs1802781; rs3936179; rs4760682; rs4760686; rs7302354; rs7485355; rs7488265; rs8804

# Metabolic_Enzyme_22_General_References:
1833270; 2526045; 2822475; 2140567; 2526044; 7550225; 7513946; 7825568; 8889589

# Metabolic_Enzyme_22_References:
Not Available

# Metabolic_Enzyme_23_ID:
6033

# Metabolic_Enzyme_23_Name:
6-phosphofructokinase, liver type

# Metabolic_Enzyme_23_Synonyms:
Phosphofructokinase 1; Phosphohexokinase; Phosphofructo-1-kinase isozyme B; PFK-B

# Metabolic_Enzyme_23_Gene_Name:
PFKL

# Metabolic_Enzyme_23_Protein_Sequence:
>6phosphofructokinase, liver type
MAAVDLEKLRASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVE
GGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDG
SLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDS
ALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWE
NFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQ
RGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQK
AMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRS
AVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESI
VENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLG
SDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFN
IHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGH
LQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFS
PVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQYRISMAAYVSGELEHVTRRTLSMDKGF


# Metabolic_Enzyme_23_Number_of_Residues:
780

# Metabolic_Enzyme_23_Molecular_Weight:
85020

# Metabolic_Enzyme_23_Theoretical_pI:
7.54

# Metabolic_Enzyme_23_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  phosphofructokinase activity
Function:  6-phosphofructokinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  protein complex
Component:  6-phosphofructokinase complex
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_23_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_23_Specific_Function:
ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

# Metabolic_Enzyme_23_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00030  Pentose phosphate pathway;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism

# Metabolic_Enzyme_23_Reaction:
ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF00365:PFK

# Metabolic_Enzyme_23_Signals:
None

# Metabolic_Enzyme_23_Transmembrane_Regions:
None

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 2.7.1.11

# Metabolic_Enzyme_23_GenBank_ID_Protein:
35431

# Metabolic_Enzyme_23_SwissProt_ID:
K6PL_HUMAN (P17858)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
PFKL

# Metabolic_Enzyme_23_Geneatlas_id:
PFKL

# Metabolic_Enzyme_23_hgnc_id:
HGNC:8876

# Metabolic_Enzyme_23_PDB_ID:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Not Available

# Metabolic_Enzyme_23_Gene_Sequence:
>2343 bp
ATGGCCGCGGTGGACCTGGAGAAGCTGCGGGCGTCGGGCGCGGGCAAGGCCATCGGCGTC
CTGACCAGCGGCGGCGACCGGCAAGGCATGAACGCTGCTGTCCGGGCTGTGACGCGCATG
GGCATTTATGTGGGTGCCAAAGTCTTCCTCATCTACGAGGGCTATGAGGGCCTCGTGGAG
GGAGGTGAGAACATCAAGCAGGCCAACTGGCTGAGCGTCTCCAACATCATCCAGCTGGGC
GGCACTATCATTGGCAGCGCTCGCTCGAAGGCCTTTACCACCAGGGAGGGGCGCCGGGCA
GCGGCCTACAACCTGGTCCAGCACGGCATCACCAACCTGTGCGTCATCGGCGGGGATGGC
AGCCTCACAGGTGCCAACATCTTCCGCAGCGAGTGGGGCAGCCTGCTGGAGGAGCTGGTG
GCGGAAGGTAAGATCTCAGAGACTACAGCCTGGACCTACTCGCACCTGAACATCGCGGGC
CTAGTGGGCTCCATCGATAACGACTTCTGCGGCACCGACATGACCATCGGCACGGACTCG
GCCCTCCACCGCATCATGGAGGTCATCGATGCCATCACCACCACTGCCCAGAGCCACCAG
AGGACCTTCGTGCTGGAAGTGATGGGCCGGCACTGCGGGTACCTGGCGCTGGTATCTGCA
CTGGCCTCAGGGGCCGACTGGCTGTTCATCCCCGAGGCTCCACCCGAGGACGGCTGGGAG
AACTTCATGTGTGAGAGGCTGGGTGAGACTCGGAGCCGTGGGTCCCGACTGAACATCATC
ATCATCGCTGAGGGTGCCATTGACCGCAACGGGAAGCCCATCTCGTCCAGCTACGTGAAG
GACCTGGTGGTTCAGAGGCTGGGCTTCGACACCCGTGTAACTGTGCTGGGCCACGTGCAG
CGGGGAGGGACGCCCTCTGCCTTCGACCGGATCCTGAGCAGCAAGATGGGCATGGAGGCG
GTGATGGCGCTGCTGGAAGCCACGCCTGACACGCCGGCCTGCGTGGTCACCCTCTCGGGG
AACCAGTCAGTGCGGCTGCCCCTCATGGAGTGCGTGCAGATGACCAAGGAAGTGCAGAAA
GCCATGGATGACAAGAGGTTTGACGAGGCCACCCAGCTCCGTGGTGGGAGCTTCGAGAAC
AACTGGAACATTTACAAGCTCCTCACCCACCAGAAGCCCCCCAAGGAGAAGTCTAACTTC
TCCCTGGCCATCCTGAATGTGGGGGCCCCGGCGGCTGGCATGAATGCGGCCGTGCGCTCG
GCGGTGCGGACCGGCATCTCCCATGGACACACAGTATACGTGGTGCACGATGGCTTCGAA
GGCCTAGCCAAGGGTCAGGTGCAAGAAGTAGGCTGGCACGACGTGGCCGGCTGGTTGGGG
CGTGGTGGCTCCATGCTGGGGACCAAGAGGACCCTGCCCAAGGGCCAGCTGGAGTCCATT
GTGGAGAACATCCGCATCTATGGTATTCACGCCCTGCTGGTGGTCGGTGGGTTTGAGGCC
TATGAAGGGGTGCTGCAGCTGGTGGAGGCTCGCGGGCGCTACGAGGAGCTCTGCATCGTC
ATGTGTGTCATCCCAGCCACCATCAGCAACAACGTCCCTGGCACCGACTTCAGCCTGGGC
TCCGACACTGCTGTAAATGCCGCCATGGAGAGCTGTGACCGCATCAAACAGTCTGCCTCG
GGGACCAAGCGCCGTGTGTTCATCGTGGAGACCATGGGGGGTTACTGTGGCTACCTGGCC
ACCGTGACTGGCATTGCTGTGGGGGCCGACGCCGCCTACGTCTTCGAGGACCCTTTCAAC
ATCCACGACTTAAAGGTCAACGTGGAGCACATGACGGAGAAGATGAAGACAGACATTCAG
AGGGGCCTGGTGCTGCGGAACGAGAAGTGCCATGACTACTACACCACGGAGTTCCTGTAC
AACCTGTACTCATCAGAGGGCAAGGGCGTCTTCGACTGCAGGACCAATGTCCTGGGCCAC
CTGCAGCAGGGTGGCGCTCCAACCCCCTTTGACCGGAACTATGGGACCAAGCTGGGGGTG
AAGGCCATGCTGTGGTTGTCGGAGAAGCTGCGCGAGGTTTACCGCAAGGGACGGGTGTTC
GCCAATGCCCCAGACTCGGCCTGCGTGATCGGCCTGAAGAAGAAGGCGGTGGCCTTCAGC
CCCGTCACTGAGCTCAAGAAAGACACTGATTTCGAGCACCGCATGCCACGGGAGCAGTGG
TGGCTGAGCCTGCGGCTCATGCTGAAGATGCTGGCACAATACCGCATCAGTATGGCCGCC
TACGTGTCAGGGGAGCTGGAGCACGTGACCCGCCGCACCCTGAGCATGGACAAGGGCTTC
TGA

# Metabolic_Enzyme_23_GenBank_ID_Gene:
X15573

# Metabolic_Enzyme_23_Chromosome_Location:
Not Available

# Metabolic_Enzyme_23_Locus:
Not Available

# Metabolic_Enzyme_23_SNPs:
rs1057037; rs9975113; rs1057034; rs2838545; rs2838544; rs2236669; rs3788115; rs8134520; rs7282369; rs8129937; rs4350841; rs3788116; rs7277792; rs2039274; rs9975994; rs1893208; rs2073436; rs2236670; rs9984426; rs7283094; rs3788117; rs3788114; rs9976073; rs9975988; rs9982262; rs9979367; rs9979369; rs9983978; rs2838550; rs2070568; rs8133730; rs3827256; rs2838549; rs2243542; rs7279267; rs2838548; rs2070569; rs2838547; rs11088947; rs2838546; rs2070571; rs928303; rs2250238; rs4818905; rs1972269; rs11909786; rs2277808; rs2776382; rs8127589; rs4818904; rs2070570; rs2276250; rs2847231; rs2876959; rs743484; rs12483184; rs2847229; rs743481; rs12483238; rs17004643; rs11908697; rs4818907; rs9977591; rs9981333; rs12482540; rs2276249; rs2276251; rs12482028; rs743483; rs2070567; rs9306096; rs2847230; rs1972267; rs9974877; rs2298692; rs1972268; rs9975413; rs4818906; rs10460741; rs9975207; rs11558848; rs11558850; rs17850433; rs17855402; rs9974772; rs9980790; rs11700493; rs34577649; rs1057222; rs3831402; rs35664594; rs2039275; rs1057197; rs8129860; rs9637179; rs8130111; rs11558849; rs35382076; rs34642010; rs9981255; rs34391295; rs34562056; rs35580361; rs34634869; rs3788120; rs34012756; rs743487; rs34319533; rs11269292; rs8133214; rs34875847; rs743486; rs9974934; rs35541329; rs35458462; rs743485; rs35890279; rs34330261; rs762425; rs3788118; rs12483015; rs34114410; rs17276063; rs9974264; rs13433407; rs743482; rs34915720; rs34644431; rs34835108; rs9975069; rs9306097; rs35213117; rs35820150; rs34193517; rs9975195; rs35158995; rs2741986; rs2741987; rs2850170; rs5844182; rs9975203; rs35045753; rs1003854; rs1056687; rs1056689; rs1056725; rs11552066; rs11552067; rs11911657; rs12627511; rs15145; rs1800521; rs1800522; rs1800524; rs1800525; rs1800526; rs2070573; rs2073610; rs2073611; rs2075877; rs2075878; rs2236441; rs2256817; rs2277809; rs2741985; rs2847225; rs3746965; rs3746966; rs3761392; rs3761393; rs3788113; rs4818709; rs4818710; rs760426; rs760427; rs933150; rs941405; rs9976610

# Metabolic_Enzyme_23_General_References:
2533063; 2139864; 10830953; 12665801

# Metabolic_Enzyme_23_References:
Not Available

# Metabolic_Enzyme_24_ID:
5341

# Metabolic_Enzyme_24_Name:
Nucleoside diphosphate kinase A

# Metabolic_Enzyme_24_Synonyms:
NDK A; NDP kinase A; Tumor metastatic process-associated protein; Metastasis inhibition factor nm23; nm23-H1; Granzyme A-activated DNase; GAAD

# Metabolic_Enzyme_24_Gene_Name:
NME1

# Metabolic_Enzyme_24_Protein_Sequence:
>Nucleoside diphosphate kinase 
AMANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRP
FFAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHG
SDSVESAEKEIGLWFHPEELVDYTSCAQNWIYE

# Metabolic_Enzyme_24_Number_of_Residues:
152

# Metabolic_Enzyme_24_Molecular_Weight:
17149

# Metabolic_Enzyme_24_Theoretical_pI:
6.11

# Metabolic_Enzyme_24_GO_Classification:
>>>
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  nucleoside diphosphate kinase activity
 ||
>>>
Process:  CTP biosynthesis
Process:  nucleoside triphosphate metabolism
Process:  nucleoside triphosphate biosynthesis
Process:  ribonucleoside triphosphate biosynthesis
Process:  pyrimidine ribonucleoside triphosphate biosynthesis
Process:  UTP biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside triphosphate biosynthesis
Process:  purine ribonucleoside triphosphate biosynthesis
Process:  GTP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_24_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_24_Specific_Function:
Major role in the synthesis of nucleoside triphosphates other than ATP

# Metabolic_Enzyme_24_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_24_Reaction:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

# Metabolic_Enzyme_24_Pfam_Domain_Function:
PF00334:NDK

# Metabolic_Enzyme_24_Signals:
None

# Metabolic_Enzyme_24_Transmembrane_Regions:
None

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 2.7.4.6

# Metabolic_Enzyme_24_GenBank_ID_Protein:
35068

# Metabolic_Enzyme_24_SwissProt_ID:
NDKA_HUMAN (P15531)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
NME1

# Metabolic_Enzyme_24_Geneatlas_id:
NME1

# Metabolic_Enzyme_24_hgnc_id:
HGNC:7849

# Metabolic_Enzyme_24_PDB_ID:
1JXV

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Cytoplasm. Nucleus

# Metabolic_Enzyme_24_Gene_Sequence:
>543 bp
TGCTGCGAACCACGTGGGTCCCGGGCGCGTTTCGGGTGCTGGCGGCTGCAGCCGGAGTTC
AAACCTAAGCAGCTGGAAGGAACCATGGCCAACTGTGAGCGTACCTTCATTGCGATCAAA
CCAGATGGGGTCCAGCGGGGTCTTGTGGGAGAGATTATCAAGCGTTTTGAGCAGAAAGGA
TTCCGCCTTGTTGGTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTAC
GTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCG
GTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGG
GAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTT
GGCAGGAACATTATACATGGCAGTGATTCTGTGGAGAGTGCAGAGAAGGAGATCGGCTTG
TGGTTTCACCCTGAGGAACTGGTAGATTACACGAGCTGTGCTCAGAACTGGATCTATGAA
TGA

# Metabolic_Enzyme_24_GenBank_ID_Gene:
X17620

# Metabolic_Enzyme_24_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_24_Locus:
17q21.3

# Metabolic_Enzyme_24_SNPs:
Not Available

# Metabolic_Enzyme_24_General_References:
2509941; 8270257; 7916650; 1851158; 2056128; 10512675; 11835509; 12972261; 12628186; 8047138

# Metabolic_Enzyme_24_References:
Not Available

# Metabolic_Enzyme_25_ID:
6174

# Metabolic_Enzyme_25_Name:
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

# Metabolic_Enzyme_25_Synonyms:
Phosphoenolpyruvate carboxylase; PEPCK-C

# Metabolic_Enzyme_25_Gene_Name:
PCK1

# Metabolic_Enzyme_25_Protein_Sequence:
>Phosphoenolpyruvate carboxykinase, cytosolic 
GTPMPPQLQNGLNLSAKVVQGSLDSLPQAVREFLENNAELCQPDHIHICDGSEEENGRLL
GQMEEEGILRRLKKYDNCWLALTDPRDVARIESKTVIVTQEQRDTVPIPKTGLSQLGRWM
SEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLSKIGIELTDSPYVVASMRIMTRMG
TPVLEAVGDGEFVKCLHSVGCPLPLQKPLVNNWPCNPELTLIAHLPDRREIISFGSGYGG
NSLLGKKCFALRMASRLAKEEGWLAEHMLILGITNPEGEKKYLAAAFPSACGKTNLAMMN
PSLPGWKVECVGDDIAWMKFDAQGHLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIF
TNVAETSDGGVYWEGIDEPLASGVTITSWKNKEWSSEDGEPCAHPNSRFCTPASQCPIID
AAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKIIMH
DPFAMRPFFGYNFGKYLAHWLSMAQHPAAKLPKIFHVNWFRKDKEGKFLWPGFGENSRVL
EWMFNRIDGKASTKLTPIGYIPKEDALNLKGLGHINMMELFSISKEFWEKEVEDIEKYLE
DQVNADLPCEIEREILALKQRISQM

# Metabolic_Enzyme_25_Number_of_Residues:
622

# Metabolic_Enzyme_25_Molecular_Weight:
69195

# Metabolic_Enzyme_25_Theoretical_pI:
6.05

# Metabolic_Enzyme_25_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  guanyl nucleotide binding
Function:  GTP binding
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
Function:  phosphoenolpyruvate carboxykinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  gluconeogenesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_25_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_25_Specific_Function:
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO(2)

# Metabolic_Enzyme_25_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00620  Pyruvate metabolism

# Metabolic_Enzyme_25_Reaction:
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2

# Metabolic_Enzyme_25_Pfam_Domain_Function:
PF00821:PEPCK

# Metabolic_Enzyme_25_Signals:
None

# Metabolic_Enzyme_25_Transmembrane_Regions:
None

# Metabolic_Enzyme_25_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_25_EC_Link:
EC 4.1.1.32

# Metabolic_Enzyme_25_GenBank_ID_Protein:
189945

# Metabolic_Enzyme_25_SwissProt_ID:
PPCKC_HUMAN (P35558)

# Metabolic_Enzyme_25_swissprot_Name:
Not Available

# Metabolic_Enzyme_25_Genecard_id:
PCK1

# Metabolic_Enzyme_25_Geneatlas_id:
PCK1

# Metabolic_Enzyme_25_hgnc_id:
HGNC:8724

# Metabolic_Enzyme_25_PDB_ID:
1NHX

# Metabolic_Enzyme_25_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_25_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_25_Gene_Sequence:
>1869 bp
ATGCCTCCTCAGCTGCAAAACGGCCTGAACCTCTCGGCCAAAGTTGTCCAGGGAAGCCTG
GACAGCCTGCCCCAGGCAGTGAGGGAGTTTCTCGAGAATAACGCTGAGCTGTGTCAGCCT
GATCACATCCACATCTGTGACGGCTCTGAGGAGGAGAATGGGCGGCTTCTGGGCCAGATG
GAGGAAGAGGGCATCCTCAGGCGGCTGAAGAAGTATGACAACTGCTGGTTGGCTCTCACT
GACCCCAGGGATGTGGCCAGGATCGAAAGCAAGACGGTTATCGTCACCCAAGAGCAAAGA
GACACAGTGCCCATCCCCAAAACAGGCCTCAGCCAGCTCGGTCGCTGGATGTCAGAGGAG
GATTTTGAGAAAGCGTTCAATGCCAGGTTCCCAGGGTGCATGAAAGGTCGCACCATGTAC
GTCATCCCATTCAGCATGGGGCCGCTGGGCTCACCTCTGTCGAAGATCGGCATCGAGCTG
ACGGATTCGCCCTACGTGGTGGCCAGCATGCGGATCATGACGCGGATGGGCACGCCCGTC
CTGGAAGCACTGGGCGATGGGGAGTTTGTCAAATGCCTCCATTCTGTGGGGTGCCCTCTG
CCTTTACAAAAGCCTTTGGTCAACAACTGGCCCTGCAACCCGGAGCTGACGCTCATCGCC
CACCTGCCTGACCGCAGAGAGATCATCTCCTTTGGCAGTGGGTACGGCGGGAACTCGCTG
CTCGGGAAGAAGTGCTTTGCTCTCAGGATGGCCAGCCGGCTGGCAGAGGAGGAAGGGTGG
CTGGCAGAGCACATGCTGATTCTGGGTATAACCAACCCTGAGGGTGAGAAGAAGTACCTG
GCGGCCGCATTTCCCAGCGCCTGCGGGAAGACCAACCTGGCCATGATGAACCCCAGCCTC
CCCGGGTGGAAGGTTGAGTGCGTCGGGGATGACATTGCCTGGATGAAGTTTGACGCACAA
GGTCATTTAAGGGCCATCAACCCAGAAAATGGCTTTTTCGGTGTCGCTCCTGGGACTTCA
GTGAAGACCAACCCCAATGCCATCAAGACCATCCAGAAGAACACAATCTTTACCAATGTG
GCCGAGACCAGCGACGGGGGCGTTTACTGGGAAGGCATTGATGAGCCGCTAGCTTCAGGC
GTCACCATCACGTCCTGGAAGAATAAGGAGTGGAGCTCAGAGGATGGGGAACCTTGTGCC
CACCCCAACTCGAGGTTCTGCACCCCTGCCAGCCAGTGCCCCATCATTGATGCTGCCTGG
GAGTCTCCGGAAGGTGTTCCCATTGAAGGCATTATCTTTGGAGGCCGTAGACCTGCTGGT
GTCCCTCTAGTCTATGAAGCTCTCAGCTGGCAACATGGAGTCTTTGTGGGGGCGGCCATG
AGATCAGAGGCCACAGCGGCTGCAGAACATAAAGGCAAAATCATCATGCATGACCCCTTT
GCCATGCGGCCCTTCTTTGGCTACAACTTCGGCAAATACCTGGCCCACTGGCTTAGCATG
GCCCAGCACCCAGCAGCCAAACTGCCCAAGATCTTCCATGTCAACTGGTTCCGGAAGGAC
AAGGAAGGCAAATTCCTCTGGCCAGGCTTTGGAGAGAACTCCAGGGTGCTGGAGTGGATG
TTCAACCGGATCGATGGAAAAGCCAGCACCAACGTCACGCCCATAGGCTACATCCCCAAG
GAGGATGCCCTGAACCTGAAAGGCCTGGGGCACATCAACATGATGGAGCTTTTCAGCATC
TCCAAGGAATTCTGGGACAAGGAGGTGGAAGACATCGAGAAGTATCTGGTGGATCAAGTC
AATGCCGACCTCCCCTGTGAAATCGAGAGAGAGATCCTTGCCTTGAAGCAAAGAATAAGC
CAGATGTAA

# Metabolic_Enzyme_25_GenBank_ID_Gene:
L05144

# Metabolic_Enzyme_25_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_25_Locus:
20q13.31

# Metabolic_Enzyme_25_SNPs:
rs707555; rs8192708; rs1804160; rs11552145; rs28359542; rs1062601; rs2070756; rs28383584; rs28359546; rs1062600; rs6070157; rs1042521; rs1042523; rs28359547; rs28359544; rs1042531; rs28359554; rs28383583; rs1023049; rs2179706; rs2236745; rs2070755; rs1040566; rs17847710; rs6025629; rs8123020; rs2236744; rs28359537; rs28359552; rs1328757; rs1328756; rs2071023; rs28383582; rs28359556; rs28383575; rs28383578; rs28383576; rs1042529; rs28383585; rs34103538; rs17847705; rs1042530; rs41302559; rs28359550; rs28383586; rs6092497; rs11552146; rs6128079; rs6128078; rs17847716; rs6070155; rs34053667; rs35463004; rs11470969; rs6070159; rs35421260; rs11471113; rs6070156; rs34726336; rs17847706; rs36212750; rs34957652; rs36204795; rs6025630; rs35760901; rs34351914; rs1042532; rs28682317; rs7351534; rs28359539; rs35295536; rs28359541; rs28359543; rs28359538; rs28359551; rs28359540; rs28359549; rs28359548; rs6070158; rs6070160; rs28383577; rs34751656; rs28383580; rs28383579; rs28383581; rs1022570; rs34808822; rs28359555; rs6025628; rs28359557; rs35912384; rs1004776; rs1022571; rs11908628; rs12479913; rs12481672; rs1543375; rs1569718; rs16981144; rs17411842; rs17411883; rs17411904; rs17411973; rs17496809; rs2073144; rs2143666; rs2179707; rs2206851; rs2235826; rs2865391; rs2902994; rs3795120; rs6015032; rs6015034; rs6025620; rs6025622; rs6025625; rs6025627; rs6025631; rs6025633; rs6025634; rs6025635; rs6025637; rs6025639; rs6064564; rs6064565; rs6064566; rs6070148; rs6070149; rs6070152; rs6070154; rs6070161; rs6070163; rs6099674; rs6123706; rs6123707; rs6128074; rs6128076; rs6128077; rs6128083; rs7274434; rs7363892; rs742725; rs8117078

# Metabolic_Enzyme_25_General_References:
8490617; 8325643; 11780052; 8547315; 11851336

# Metabolic_Enzyme_25_References:
Not Available

End of HMDB00189

Beginning of HMDB00190
# Accession_No:
HMDB00190

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-23 13:17:41

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
L-Lactic acid

# Description:
Lactic acid plays a role in several biochemical processes and is produced in the muscles during intense activity. Lactate measurement in the critically ill has been traditionally used to stratify patients with poor outcome. However, plasma lactate levels are the result of a finely tuned interplay of factors that affect the balance between its production and its clearance. When the oxygen supply does not match its consumption, organisms such as man who are forced to produce ATP for their integrity adapt in many different ways up to the point when energy failure occurs. Lactate, being part of the adaptive response, may then be used to assess the severity of the supply/demand imbalance. In such a scenario, the time to intervention becomes relevant: early and effective treatment may allow the cell to revert to a normal state, as long as the oxygen machinery (i.e. mitochondria) is intact. Conversely, once the mitochondria are deranged, energy failure occurs even in the presence of normoxia. The lactate increase in critically ill patients may therefore be viewed as an early marker of a potentially reversible state. (PMID 16356243) A number of studies have demonstrated that malignant transformation is associated with an increase in glycolytic flux and in anaerobic and aerobic cellular lactate excretion. Using quantitative bioluminescence imaging in various primary carcinomas in patients (uterine cervix, head and neck, colorectal region) at first diagnosis of the disease, lactate concentrations in tumors in vivo could be relatively low or extremely high (up to 40 micromol/g) in different individual tumors or within the same lesion. In all tumor entities investigated, high molar concentrations of lactate were correlated with a high incidence of distant metastasis already in an early stage of the disease. Low lactate tumors (< median of approx. 8 micromol/g) were associated with both a longer overall and disease free survival compared to high lactate lesions (lactate > approx. 8 micromol/g). Lactate dehydrogenase was found to be upregulated in most of these tumors compared to surrounding normal tissue. (PMID 15279558)

# Synonyms:
(+)-Lactate; (+)-Lactic acid; (S)-(+)-2-Hydroxypropanoate; (S)-(+)-2-Hydroxypropanoic acid; (S)-2-Hydroxypropanoic acid; (S)-2-Hydroxypropionate; (S)-2-Hydroxypropionic acid; (S)-2-hydroxy-Propanoate; (S)-2-hydroxy-Propanoic acid; (S)-Lactate; (S)-Lactic acid; (alpha)-Lactate; (alpha)-Lactic acid; 1-Hydroxyethane 1-carboxylate; 1-Hydroxyethane 1-carboxylic acid; 1-Hydroxyethanecarboxylate; 1-Hydroxyethanecarboxylic acid; 2-Hydroxypropanoate; 2-Hydroxypropionate; L-2-Hydroxypropanoate; L-2-Hydroxypropanoic acid; Milk acid; Sarcolactic acid; a-Hydroxypropanoate; a-Hydroxypropionate; a-Hydroxypropionic acid; alpha-Hydroxypropanoate; alpha-Hydroxypropionate; l-(+)- lactic acid; alpha-Hydroxypropionic acid

# Chemical_IUPAC_Name:
(2S)-2-hydroxypropanoic acid

# Chemical_Formula:
C3H6O3

# Chemical_Structure:
tbl_chemical:::HMDB00190_ZOOM.png:::119283242103415986

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00190_THUMB.png:::119283241963881624

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
secondary alcohol; carboxylic acid; alpha-hydroxyacid

# Taxonomy_Biofunction:
Component of Cysteine metabolism; Component of Propanoate metabolism; Component of Pyruvate metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
90.03169

# Molecular_Weight_Avg:
90.07794

# Smiles_String_isomeric:
C[C@H](O)C(O)=O

# Smiles_String_canonical:
CC(O)C(O)=O

# KEGG_Compound_ID:
C00186

# BioCyc_ID:
L-LACTATE

# PubChem_CID:
107689

# PubChem_SID:
7990899; 3133728; 584014; 584016; 830465; 684938; 7888600; 587061; 10234386; 8145829; 3486

# OMIM_ID:
150000; 220110; 245340; 245349; 245450; 255125; 256000; 608782

# Metagene_ID:
Not Available

# BiGG_ID:
34179

# Wikipedia_ID:
Lactate

# METLIN_ID:
5205

# Ref_ID:
7819686; 15627241; 8579834; 6411064; 9693263; 9625050; 11446841; 11268691; 7729054; 1931558; 12097436; 16324927; 15882454; 8412012; 15780050

# ChEBI_ID:
16651

# CAS_Registry_Number:
79-33-4

# InChI:
InChI=1/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m0/s1

# Synthesis_Reference:
Journal of Organic Chemistry  (1982),  47(14),  2816-18

# Melting_Point:
16.8 oC (BP = 119 oC)

# Melting_Point_predicted:
25.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
1000.0 mg/mL [MEYLAN,WM et al. (1996)]; 562.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Liquid

# LogP:
Not Available

# LogP_predicted:
-0.79 [Predicted by ALOGPS]; -0.6 [Predicted by PubChem via XLOGP]; -0.65 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::L-Lactic_acid.mol:::1132723812875855809

# SDF_File_[Text]:
tbl_chemical:::HMDB00190.sdf:::119283241673851108

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00190.pdb:::119283241825962977

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::050122_P00_08_IS_1DP_presat.png:::115636164355388999

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::050122_P00_08_IS_1DP_presat.zip:::115636164357664907

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050122_P00_08_IS_1DP_Assigned.png:::115636162756425567

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::050122_P00_08_IS_1DC_112.jpg:::114168392190632493

# C_NMR_FIDS_Spectra:
tbl_cnmr:::050122_P00_08_IS_1DC_112.zip:::114168392187275033

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::050122_P00_08_IS_1DC_112_Assigned.jpg:::114332824781472695

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041020_P00_05_HW_2DHSQC_384.png:::11828905009553591

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041020_P00_05_HW_2DHSQC_384.zip:::118289050099429127

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041020_P00_05_HW_2DHSQC_384_Assigned.png:::118289050240453084

# Predicted_H_NMR_Spectrum:
tbl_chemical:::L-Lactic acid.gif:::1132732120234661780

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00190_peaks.txt:::1156309606302954501

# Predicted_C_NMR_Spectrum:
tbl_chemical:::L-Lactic acid_C.gif:::1132737717243242526

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00190_peaks.txt:::1156310795641452017

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00190LLLLLLL.png:::11755495539111651; Medium Energy:tbl_ms:::HMDB00190MMMMMMM.png:::117554956806047015; High Energy:tbl_ms:::HMDB00190HHHHHHH.png:::117554958255999625

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000208.png:::116907444767188087

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000208.txt:::116907444767130309

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000208.png:::116890831484397344

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000208.txt:::11689083150626860

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Bile; Blood; CSF; Cellular Cytoplasm; Saliva; Urine

# Concentration_[Normal]:
Urine	30.9	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9625050
Blood	740.0 +/- 2400.0	uM	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	2390.0 +/- 990.0	umol/L	Newborn:0-30_days_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	1140.0 +/- 360.0	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	1510.0 (740.0-2400.0)	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	2000.0	umol/L	Adult:>18_yrs_old	Both	Normal	6411064
Blood	1806.0 (367.0-3245.0)	umol/L	Newborn:0-30_days_old	Both	Normal	7819686
Cerebrospinal_Fluid(CSF)	1590.0 +/- 330.0	uM	Children:1-13_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	850.0 +/- 400.0 	uM	Adult:>18_yrs_old	Both	Normal	8412012; 
Cerebrospinal_Fluid(CSF)	2240.0 +/- 600.0	uM	Adult:>18_yrs_old	N/A	Normal	1931558
Cerebrospinal_Fluid(CSF)	850.0 (450.0-2100.0)	umol/L	Adult:>18_yrs_old	N/A	Normal	8412012
Cerebrospinal_Fluid(CSF)	3000.0 (1850.0-4150.0)	umol/L	Adult:>18_yrs_old	Both	Normal	15627241
Cerebrospinal_Fluid(CSF)	1770.0 (930.0-2600.0)	umol/L	Adult:>18_yrs_old	Both	Normal	7729054
Saliva	50490 (80.0-100900)	umol/L	Adult:>18_yrs_old	Both	Normal	12097436
Cellular_Cytoplasm	3200 (2900-3500)	umol/L	Adult:>18_yrs_old	Both	Normal	8579834
Cellular_Cytoplasm	1100 (600-1600)	umol/L	Adult:>18_yrs_old	Both	Normal	15882454


# Concentration_[Abnormal]:
Urine	440	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Paraquat poisoning	9625050
Blood	6400 (4400-8400)	umol/L	Adult:>18_yrs_old	Both	Exercise	16324927
Cerebrospinal_Fluid(CSF)	4577.0 (1684.0-7470.0)	umol/L	Adult:>18_yrs_old	Both	Dementia of Alzheimer type (DAT)	9693263
Bile	>10	umol/L	Adult:>18_yrs_old	Both	Hepatic and biliary malignancies	15780050
Cellular_Cytoplasm	16000 (13000-19000)	umol/L	Adult:>18_yrs_old	Both	Anoxia	8579834


# Associated_Disorders:
Acute Liver Failure; Anoxia; Bacterial meningitis; Cerebral malaria; Dementia of Alzheimer Type (DAT); Disc herniation; Exercise; Hepatic and biliary malignancies; Huntington chorea; Hyperpnoea; Multiple Organ Dysfunction Syndrome; Non-Hodgkin's lymphoma; Paraquat poisoning; Spina bifida; Subarachnoid haemorrhage

# Pathway_Names:
Glycolysis;Pyruvate metabolism;Propanoate metabolism

# Pathway_Images:
Glycolysis.jpg;;

# KEGG_Images:
map00010;map00620;map00640

# Pathway_Graphs:
Glycolysis_Graph.jpg;;

# Pathway_SBMLs:
Glycolysis.xml;;

# Metabolic_Enzyme_1_ID:
5794

# Metabolic_Enzyme_1_Name:
L-lactate dehydrogenase A-like 6B

# Metabolic_Enzyme_1_Synonyms:
Not Available

# Metabolic_Enzyme_1_Gene_Name:
LDHAL6B

# Metabolic_Enzyme_1_Protein_Sequence:
>Llactate dehydrogenase Alike 6
BMSWTVPVVRASQRVSSVGANFLCLGMALCPRQATRIPLNGTWLFTPVSKMATVKSELIE
RFTSEKPVHHSKVSIIGTGSVGMACAISILLKGLSDELALVDLDEDKLKGETMDLQHGSP
FTKMPNIVCSKDYFVTANSNLVIITAGARQEKGETRLNLVQRNVAIFKLMISSIVQYSPH
CKLIIVSNPVDILTYVAWKLSAFPKNRIIGSGCNLDTARFRFLIGQKLGIHSESCHGWIL
GEHGDSSVPVWSGVNIAGVPLKDLNSDIGTDKDPEQWKNVHKEVTATAYEIIKMKGYTSW
AIGLSVADLTESILKNLRRIHPVSTIIKGLYGIDEEVFLSIPCILGENGITNLIKIKLTP
EEEAHLKKSAKTLWEIQNKLKL

# Metabolic_Enzyme_1_Number_of_Residues:
381

# Metabolic_Enzyme_1_Molecular_Weight:
41943

# Metabolic_Enzyme_1_Theoretical_pI:
8.89

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  anaerobic glycolysis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
(S)-lactate + NAD(+) = pyruvate + NADH

# Metabolic_Enzyme_1_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00272  Cysteine metabolism;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_1_Reaction:
(S)-lactate + NAD+ = pyruvate + NADH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF02866:Ldh_1_C;
PF00056:Ldh_1_N

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.1.1.27

# Metabolic_Enzyme_1_GenBank_ID_Protein:
12331000

# Metabolic_Enzyme_1_SwissProt_ID:
LDH6B_HUMAN (Q9BYZ2)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
LDHAL6B

# Metabolic_Enzyme_1_Geneatlas_id:
LDHAL6B

# Metabolic_Enzyme_1_hgnc_id:
HGNC:21481

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1146 bp
ATGAGTTGGACTGTGCCTGTTGTGCGGGCCAGCCAGAGAGTGAGCTCGGTGGGAGCGAAT
TTCCTATGCCTGGGGATGGCCCTGTGTCCGCGTCAAGCAACGCGCATCCCGCTCAACGGC
ACCTGGCTCTTCACCCCCGTGAGCAAGATGGCGACTGTGAAGAGTGAGCTTATTGAGCGT
TTCACTTCCGAGAAGCCCGTTCATCACAGTAAGGTCTCCATCATAGGAACTGGATCGGTG
GGCATGGCCTGCGCTATCAGCATCTTATTAAAAGGCTTGAGTGATGAACTTGCCCTTGTG
GATCTTGATGAAGACAAACTGAAGGGTGAGACGATGGATCTTCAACATGGCAGCCCTTTC
ACGAAAATGCCAAATATTGTTTGTAGCAAAGATTACTTTGTCACAGCAAACTCCAACCTA
GTGATTATCACAGCAGGTGCACGCCAAGAAAAGGGAGAAACGCGCCTTAATTTAGTCCAG
CGAAATGTGGCCATCTTCAAGTTAATGATTTCCAGTATTGTCCAGTACAGCCCCCACTGC
AAACTGATTATTGTTTCCAATCCAGTGGATATCTTAACTTATGTAGCTTGGAAGTTGAGT
GCATTTCCCAAAAACCGTATTATTGGAAGCGGCTGTAATCTGGATACTGCTCGTTTTCGT
TTCTTGATTGGACAAAAGCTTGGTATCCATTCTGAAAGCTGCCATGGATGGATCCTCGGA
GAGCATGGAGACTCAAGTGTTCCTGTGTGGAGTGGAGTGAACATAGCTGGTGTCCCTTTG
AAGGATCTGAACTCTGATATAGGAACTGATAAAGATCCTGAGCAATGGAAAAATGTCCAC
AAAGAAGTGACTGCAACTGCCTATGAGATTATTAAAATGAAAGGTTATACTTCTTGGGCC
ATTGGCCTATCTGTGGCCGATTTAACAGAAAGTATTTTGAAGAATCTTAGGAGAATACAT
CCAGTTTCCACCATAATTAAGGGCCTCTATGGAATAGATGAAGAAGTATTCCTCAGTATT
CCTTGTATCCTGGGAGAGAACGGTATTACCAACCTTATAAAGATAAAGCTGACCCCTGAA
GAAGAGGCCCATCTGAAAAAAAGTGCAAAAACACTCTGGGAAATTCAGAATAAGCTTAAG
CTTTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AY009108

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_1_Locus:
15q22.2

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
Not Available

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5793

# Metabolic_Enzyme_2_Name:
L-lactate dehydrogenase A chain

# Metabolic_Enzyme_2_Synonyms:
LDH-A; LDH muscle subunit; LDH-M; Proliferation-inducing gene 19 protein; Renal carcinoma antigen NY-REN-59

# Metabolic_Enzyme_2_Gene_Name:
LDHA

# Metabolic_Enzyme_2_Protein_Sequence:
>Llactate dehydrogenase A chain
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF

# Metabolic_Enzyme_2_Number_of_Residues:
332

# Metabolic_Enzyme_2_Molecular_Weight:
36689

# Metabolic_Enzyme_2_Theoretical_pI:
8.45

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  anaerobic glycolysis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
(S)-lactate + NAD(+) = pyruvate + NADH

# Metabolic_Enzyme_2_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00272  Cysteine metabolism;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_2_Reaction:
(S)-lactate + NAD+ = pyruvate + NADH + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF02866:Ldh_1_C;
PF00056:Ldh_1_N

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.1.27

# Metabolic_Enzyme_2_GenBank_ID_Protein:
34313

# Metabolic_Enzyme_2_SwissProt_ID:
LDHA_HUMAN (P00338)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
LDHA

# Metabolic_Enzyme_2_Geneatlas_id:
LDHA

# Metabolic_Enzyme_2_hgnc_id:
HGNC:6535

# Metabolic_Enzyme_2_PDB_ID:
1I10

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>999 bp
ATGGCAACTCTAAAGGATCAGCTGATTTATAATCTTCTAAAGGAAGAACAGACCCCCCAG
AATAAGATTACAGTTGTTGGGGTTGGTGCTGTTGGCATGGCCTGTGCCATCAGTATCTTA
ATGAAGGACTTGGCAGATGAACTTGCTCTTGTTGATGTCATCGAAGACAAATTGAAGGGA
GAGATGATGGATCTCCAACATGGCAGCCTTTTCCTTAGAACACCAAAGATTGTCTCTGGC
AAAGACTATAATGTAACTGCAAACTCCAAGCTGGTCATTATCACGGCTGGGGCACGTCAG
CAAGAGGGAGAAAGCCGTCTTAATTTGGTCCAGCGTAACGTGAACATATTTAAATTCATC
ATTCCTAATGTTGTAAAATACAGCCCGAACTGCAAGTTGCTTATTGTTTCAAATCCAGTG
GATATCTTGACCTACGTGGCTTGGAAGATAAGTGGTTTTCCCAAAAACCGTGTTATTGGA
AGTGGTTGCAATCTGGATTCAGCCCGATTCCGTTACCTGATGGGGGAAAGGCTGGGAGTT
CACCCATTAAGCTGTCATGGGTGGGTCCTTGGGGAACATGGAGATTCCAGTGTGCCTGTA
TGGAGTGGAATGAATGTTGCTGGTGTCTCTCTGAAGACTCTGCACCCAGATTTAGGGACT
GATAAAGATAAGGAACAGTGGAAAGAGGTTCACAAGCAGGTGGTTGAGAGTGCTTATGAG
GTGATCAAACTCAAAGGCTACACATCCTGGGCTATTGGACTCTCTGTAGCAGATTTGGCA
GAGAGTATAATGAAGAATCTTAGGCGGGTGCACCCAGTTTCCACCATGATTAAGGGTCTT
TACGGAATAAAGGATGATGTCTTCCTTAGTGTTCCTTGCATTTTGGGACAGAATGGAATC
TCAGACCTTGTGAAGGTGACTCTGACTTCTGAGGAAGAGGCCCGTTTGAAGAAGAGTGCA
GATACACTTTGGGGGATCCAAAAGGAGCTGCAATTTTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X02152

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_2_Locus:
11p15.4

# Metabolic_Enzyme_2_SNPs:
rs5030621; rs4820; rs6498; rs7932887; rs7111748; rs2403279; rs1969565; rs2249631; rs1830425; rs1881716; rs1830426; rs4757652; rs6486425; rs3781641; rs10832932; rs2896526; rs4274186; rs7121244; rs12284013; rs12274651; rs10766475; rs3758680; rs10832928; rs10832931; rs16935411; rs10766476; rs1969563; rs11601413; rs7117399; rs12576300; rs10832929; rs10832933; rs1969564; rs16935413; rs7120485; rs7130990; rs7947664; rs1969562; rs11024644; rs6486424; rs7101840; rs10832930; rs7128549; rs7129689; rs3758682; rs2403278; rs3758683; rs3758681; rs4757650; rs6486423; rs11553874; rs34305721; rs11553873; rs11553866; rs11553870; rs12790695; rs11553865; rs7107861; rs12278153; rs4757651; rs11553862; rs35609290; rs34692667; rs12293161; rs14790; rs14789; rs35726777; rs35873857; rs35510986; rs11024642; rs35960334; rs35254161; rs12788225; rs11024645; rs12221941; rs34970587; rs10562494; rs12221918; rs12221905; rs11024643; rs33912958; rs5790035; rs11601409; rs35073059; rs11024641; rs6144242; rs34302007; rs10554414; rs10684351; rs12789257; rs6144241; rs35006409; rs35938126; rs34740438; rs35797685; rs11403792; rs35341031; rs11383902; rs35007005; rs10832927; rs10832934; rs11024640; rs11024647; rs11024649; rs11605386; rs12269752; rs12578098; rs2037868; rs3740714; rs3809096; rs3809097; rs3809098; rs4757653; rs4757661; rs7106099

# Metabolic_Enzyme_2_General_References:
3838278; 3000353; 1959923; 10508479; 1445373; 7908613

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5792

# Metabolic_Enzyme_3_Name:
L-lactate dehydrogenase C chain

# Metabolic_Enzyme_3_Synonyms:
LDH-C; LDH testis subunit; LDH-X

# Metabolic_Enzyme_3_Gene_Name:
LDHC

# Metabolic_Enzyme_3_Protein_Sequence:
>Llactate dehydrogenase C chain
MSTVKEQLIEKLIEDDENSQCKITIVGTGAVGMACAISILLKDLADELALVDVALDKLKG
EMMDLQHGSLFFSTSKITSGKDYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSI
IPAIVHYSPDCKILVVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGV
HPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLGTDSDKEHWKNIHKQVIQSAYE
IIKLKGYTSWAIGLSVMDLVGSILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGV
SDVVKINLNSEEEALFKKSAETLWNIQKDLIF

# Metabolic_Enzyme_3_Number_of_Residues:
332

# Metabolic_Enzyme_3_Molecular_Weight:
36312

# Metabolic_Enzyme_3_Theoretical_pI:
7.53

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  anaerobic glycolysis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
Possible role in sperm motility

# Metabolic_Enzyme_3_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00272  Cysteine metabolism;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_3_Reaction:
(S)-lactate + NAD+ = pyruvate + NADH + H+

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF02866:Ldh_1_C;
PF00056:Ldh_1_N

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.1.1.27

# Metabolic_Enzyme_3_GenBank_ID_Protein:
307120

# Metabolic_Enzyme_3_SwissProt_ID:
LDHC_HUMAN (P07864)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
LDHC

# Metabolic_Enzyme_3_Geneatlas_id:
LDHC

# Metabolic_Enzyme_3_hgnc_id:
HGNC:6544

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>999 bp
ATGTCAACTGTCAAGGAGCAGCTAATTGAGAAGCTAATTGAGGATGATGAAAACTCCCAG
TGTAAAATTACTATTGTTGGAACTGGTGCCGTAGGCATGGCTTGTGCTATTAGTATCTTA
CTGAAGGATTTGGCTGATGAACTTGCCCTTGTTGATGTTGCATTGGACAAACTGAAGGGA
GAAATGATGGATCTTCAGCATGGCAGTCTTTTCTTTAGTACTTCAAAGGTTACTTCTGGA
AAAGATTACAGTGTATCTGCAAACTCCAGAATAGTTATTGTCACAGCAGGTGCAAGGCAG
CAGGAGGGAGAAACTCGCCTTGCCCTGGTCCAACGTAATGTGGCTATAATGAAAATAATC
ATTCCTGCCATAGTCCATTATAGTCCTGATTGTAAAATTCTTGTTGTTTCAAATCCAGTG
GATATTTTGACATATATAGTCTGGAAGATAAGTGGCTTACCTGTAACTCGTGTAATTGGA
AGTGGTTGTAATCTAGACTCTGCCCGTTTCCGTTACCTAATTGGAGAAAAGTTGGGTGTC
CACCCCACAAGCTGCCATGGTTGGATTATTGGAGAACATGGTGATTCTAGTGTGCCCTTA
TGGAGTGGGGTGAATGTTGCTGGTGTTGCTCTGAAGACTCTGGACCCTAAATTAGGAACG
GATTCAGATAAGGAACACTGGAAAAATATCCATAAACAAGTTATTCAAAGTGCCTATGAA
ATTATCAAGCTGAAGGGGTATACCTCTTGGGCTATTGGACTGTCTGTGATGGATCTGGTA
GGATCCATTTTGAAAAATCTTAGGAGAGTGCACCCAGTTTCCACCATGGTTAAGGGATTA
TATGGAATAAAAGAAGAACTCTTTCTCAGTATCCCTTGTGTCTTGGGGCGGAATGGTGTC
TCAGATGTTGTGAAAATTAACTTGAATTCTGAGGAGGAGGCCCTTTTCAAGAAGAGTGCA
GAAACACTTTGGAATATTCAAAAGGATCTAATATTTTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
J02938

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_3_Locus:
11p15.5-p15.3

# Metabolic_Enzyme_3_SNPs:
rs16935436; rs1881717; rs12293002; rs2037868; rs1908560; rs2056781; rs2896527; rs2403280; rs1406580; rs2658566; rs7111815; rs2643856; rs2721126; rs2658551; rs11024647; rs3740713; rs12270402; rs10832934; rs7938942; rs12289603; rs2658548; rs4757662; rs10766478; rs16935432; rs16935431; rs16935424; rs2403298; rs2698563; rs12416742; rs11606494; rs2056783; rs2698566; rs7110605; rs10766477; rs11024648; rs2698558; rs6486427; rs35593189; rs2056782; rs4757664; rs2643857; rs2698568; rs2658549; rs11024651; rs12282669; rs11024649; rs968895; rs1848049; rs2658553; rs12576249; rs4757663; rs11605386; rs3809096; rs3809098; rs4757660; rs7938267; rs3809097; rs7951953; rs4757656; rs1506520; rs4757655; rs11558332; rs11558333; rs2658565; rs3740714; rs10610261; rs12807225; rs11292121; rs2463909; rs35077834; rs4756943; rs11024652; rs11024657; rs35754271; rs35064545; rs11325380; rs34480310; rs33998563; rs2056784; rs2643871; rs34279411; rs36113234; rs1318593; rs7481716; rs2643855; rs2721120; rs11024653; rs35128109; rs4628652; rs12806009; rs11313322; rs184855; rs4990347; rs1908561; rs2643859; rs34485747; rs36038254; rs35126672; rs35017114; rs35689913; rs34109624; rs35720604; rs35770509; rs34907251; rs34630228; rs35915766; rs12803458; rs34176196; rs5790036; rs4990348; rs11024650; rs1506519; rs2698562; rs34844393; rs34305958; rs3074202; rs11024655; rs34903699; rs4990349; rs12801224; rs7112151; rs2698569; rs2698557; rs35478086; rs4990345; rs1908562; rs11308924; rs2658550; rs35313043; rs12795955; rs35861956; rs35617285; rs36043375; rs2721125; rs34960411; rs1848048; rs34287236; rs35857834; rs33993685; rs34546967; rs11024656; rs2254195; rs5790037; rs36045982; rs34500057; rs4990346; rs171495; rs11321502; rs34884188; rs35134819; rs2698561; rs35976847; rs187227; rs34511927; rs35749455; rs2721124; rs35284710; rs2643860; rs28729286; rs2643872; rs35299578; rs34684673; rs35515498; rs12799374; rs35192552; rs7115524; rs189660; rs2643858; rs7111938; rs34515949; rs4757659; rs4757661; rs4757658; rs4757657; rs10832932; rs11024643; rs11024645; rs11605559; rs12269752; rs16935411; rs16935413; rs1881716; rs2721121; rs34305721; rs34546419; rs35864573; rs3758680; rs3758681; rs3758682; rs3758683; rs3781641; rs4757653; rs6486425

# Metabolic_Enzyme_3_General_References:
2440048; 2930531

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
6175

# Metabolic_Enzyme_4_Name:
L-lactate dehydrogenase A-like 6A

# Metabolic_Enzyme_4_Synonyms:
Not Available

# Metabolic_Enzyme_4_Gene_Name:
LDHAL6A

# Metabolic_Enzyme_4_Protein_Sequence:
>Llactate dehydrogenase Alike 6
AMATIKSELIKNFAEEEAIHHNKISIVGTGSVGVACAISILLKGLSDELVLVDVDEGKLK
GETMDLQHGSPFMKMPNIVSSKDYLVTANSNLVIITAGARQKKGETRLDLVQRNVSIFKL
MIPNITQYSPHCKLLIVTNPVDILTYVAWKLSGFPKNRVIGSGCNLDSARFRYFIGQRLG
IHSESCHGLILGEHGDSSVPVWSGVNIAGVPLKDLNPDIGTDKDPEQWENVHKKVISSGY
EMVKMKGYTSWGISLSVADLTESILKNLRRVHPVSTLSKGLYGINEDIFLSVPCILGENG
ITDLIKVKLTLEEEACLQKSAETLWEIQKELKL

# Metabolic_Enzyme_4_Number_of_Residues:
332

# Metabolic_Enzyme_4_Molecular_Weight:
36508

# Metabolic_Enzyme_4_Theoretical_pI:
7.00

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  anaerobic glycolysis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
(S)-lactate + NAD(+) = pyruvate + NADH

# Metabolic_Enzyme_4_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00272  Cysteine metabolism;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_4_Reaction:
(S)-lactate + NAD+ = pyruvate + NADH + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF02866:Ldh_1_C;
PF00056:Ldh_1_N

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.1.1.27

# Metabolic_Enzyme_4_GenBank_ID_Protein:
46405145

# Metabolic_Enzyme_4_SwissProt_ID:
LDH6A_HUMAN (Q6ZMR3)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
LDHAL6A

# Metabolic_Enzyme_4_Geneatlas_id:
LDHAL6A

# Metabolic_Enzyme_4_hgnc_id:
HGNC:28335

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>999 bp
ATGGCAACTATCAAGAGTGAACTTATTAAGAATTTCGCGGAAGAGGAGGCCATTCATCAC
AATAAGATCTCCATTGTAGGAACTGGATCGGTTGGTGTGGCTTGTGCTATCAGCATCTTA
TTAAAAGGTTTGAGTGATGAACTTGTCCTTGTGGATGTTGATGAAGGCAAACTGAAGGGT
GAGACAATGGATCTTCAACATGGCAGCCCTTTTATGAAAATGCCAAATATTGTCTCCAGC
AAAGATTACCTGGTCACTGCAAACTCCAATCTAGTGATTATCACAGCAGGTGCACGCCAG
AAAAAAGGAGAAACACGCCTTGATTTAGTCCAGCGAAATGTATCCATCTTTAAATTAATG
ATTCCCAATATTACCCAGTACAGTCCTCACTGCAAACTGCTTATTGTTACTAATCCAGTG
GATATCTTAACTTATGTAGCCTGGAAGTTGAGTGGATTTCCCAAAAACCGTGTTATTGGA
AGTGGTTGTAATCTGGACTCTGCTCGTTTTCGTTACTTTATTGGGCAAAGGCTTGGCATC
CACTCTGAAAGCTGTCATGGGCTGATCCTTGGAGAGCATGGCGACTCAAGTGTTCCTGTG
TGGAGTGGTGTGAACATTGCTGGCGTCCCTCTGAAGGATCTGAACCCAGATATAGGAACT
GATAAAGATCCTGAGCAGTGGGAAAATGTCCACAAAAAAGTGATTTCCAGTGGCTATGAG
ATGGTCAAAATGAAAGGTTATACTTCTTGGGGCATTAGCCTATCTGTAGCTGATTTAACA
GAAAGTATTTTGAAGAATCTTAGGAGAGTGCATCCAGTTTCTACCCTAAGTAAGGGCCTC
TATGGAATAAATGAAGACATATTCCTTAGTGTCCCATGTATCCTGGGAGAGAATGGTATC
ACAGACCTCATAAAAGTAAAACTGACTCTTGAAGAGGAGGCCTGCTTGCAAAAGAGTGCA
GAAACACTTTGGGAAATTCAGAAGGAGCTCAAGCTTTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AY581313

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_4_Locus:
11p15.1

# Metabolic_Enzyme_4_SNPs:
rs16935458; rs12419360; rs3839960; rs11024671; rs4757666; rs11024670; rs11605559; rs3993291; rs12575390; rs3993285; rs11819849; rs7113442; rs2056780; rs12420014; rs10832937; rs2658560; rs2063015; rs3993293; rs7938977; rs2658563; rs12799689; rs2658559; rs7938636; rs3993292; rs11024667; rs12361289; rs2658558; rs3993284; rs11024664; rs2698559; rs17851142; rs17851143; rs7944726; rs2658557; rs12421784; rs35039697; rs34981749; rs2721121; rs12788352; rs181713; rs2658561; rs34362860; rs34508267; rs35315254; rs12801344; rs34785727; rs5790038; rs11024669; rs11024662; rs2698560; rs12798913; rs34941058; rs34780803; rs2698570; rs34189006; rs34385147; rs12791114; rs12223887; rs36174399; rs34248982; rs7947407; rs189826; rs12786835; rs7947914; rs2658562; rs10669642; rs12270529; rs12786864; rs12788367; rs12786466; rs35193308; rs11024661; rs12788196; rs11024668; rs28825401; rs11024666; rs12800656; rs7119822; rs28769365; rs11367641; rs12799209; rs34501848; rs12223858; rs11449786; rs36036511; rs34821405; rs34725499; rs2643864; rs28824265; rs36151265; rs11024665; rs35946818; rs35950210; rs12786468; rs12271792; rs7939007; rs11024663; rs34553490; rs10697966; rs4757668; rs2643865; rs12786850; rs12801220; rs28773289; rs7927767; rs4757667; rs35999851; rs35002864; rs12808153; rs34670581; rs34459973; rs12271736; rs35864573; rs2721122; rs11274769; rs11024660; rs3830385; rs34699662; rs11024677; rs12282669; rs12289603; rs12576836; rs12803458; rs12806009; rs12808078; rs15387; rs16935432; rs16935436; rs17492613; rs1804795; rs1881717; rs2279900; rs2279901; rs2291751; rs2291752; rs2291753; rs2291754; rs2463909; rs2658555; rs2658556; rs2658565; rs34546419; rs3781640; rs6486430; rs7111938; rs7112151; rs7113379; rs8018

# Metabolic_Enzyme_4_General_References:
Not Available

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5791

# Metabolic_Enzyme_5_Name:
L-lactate dehydrogenase B chain

# Metabolic_Enzyme_5_Synonyms:
LDH-B; LDH heart subunit; LDH-H; Renal carcinoma antigen NY-REN-46

# Metabolic_Enzyme_5_Gene_Name:
LDHB

# Metabolic_Enzyme_5_Protein_Sequence:
>Llactate dehydrogenase B chain
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLK
GEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKF
IIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLG
IHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAY
EVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARG
LTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL

# Metabolic_Enzyme_5_Number_of_Residues:
334

# Metabolic_Enzyme_5_Molecular_Weight:
36639

# Metabolic_Enzyme_5_Theoretical_pI:
5.93

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  anaerobic glycolysis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_5_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_5_Specific_Function:
(S)-lactate + NAD(+) = pyruvate + NADH

# Metabolic_Enzyme_5_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00272  Cysteine metabolism;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_5_Reaction:
(S)-lactate + NAD+ = pyruvate + NADH + H+

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF02866:Ldh_1_C;
PF00056:Ldh_1_N

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.1.1.27

# Metabolic_Enzyme_5_GenBank_ID_Protein:
1200083

# Metabolic_Enzyme_5_SwissProt_ID:
LDHB_HUMAN (P07195)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
LDHB

# Metabolic_Enzyme_5_Geneatlas_id:
LDHB

# Metabolic_Enzyme_5_hgnc_id:
HGNC:6541

# Metabolic_Enzyme_5_PDB_ID:
1I0Z

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>129 bp
ATGGCAACTCTTAAGGAAAAACTCATTGCACCAGTTGCGGAAGAAGAGGCAACAGTTCCA
AACAATAAGATCACTGTAGTGGGTGTTGGACAAGTTGGTATGGCGTGTGCTATCAGCATT
CTGGGAAAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X13794

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_5_Locus:
12p12.2-p12.1

# Metabolic_Enzyme_5_SNPs:
rs3575; rs1650294; rs7297559; rs1677073; rs1629683; rs1677074; rs187457; rs7953579; rs1030452; rs1650318; rs1030453; rs11046147; rs1677075; rs11833048; rs4762716; rs1650315; rs4237915; rs1677076; rs1650317; rs1650307; rs1677111; rs1650300; rs1478293; rs1540405; rs1677108; rs1650301; rs1677110; rs1650305; rs7135799; rs1650289; rs759934; rs1650313; rs1650291; rs1677085; rs1677106; rs1650287; rs1650295; rs1677080; rs1677133; rs1650293; rs1614040; rs1677127; rs1624003; rs1677107; rs1650286; rs1650310; rs1677104; rs1677132; rs1616390; rs1650312; rs1650290; rs1677079; rs12319089; rs2114897; rs759932; rs1677129; rs1613896; rs1613889; rs1650306; rs1072993; rs1677124; rs759933; rs4275672; rs4337087; rs1650314; rs1677105; rs1677131; rs1677078; rs1072992; rs12312170; rs1677134; rs1677084; rs1677083; rs1677126; rs1650296; rs1650292; rs1650288; rs962947; rs1677128; rs1677125; rs2247376; rs1677139; rs1650283; rs1677140; rs153940; rs1677137; rs1650284; rs1677135; rs1677138; rs3759235; rs11547923; rs11547925; rs35460727; rs11547922; rs11547927; rs7966339; rs15140; rs11547926; rs11547929; rs11547931; rs11319412; rs15141; rs3203471; rs5796920; rs12368587; rs28369044; rs1650304; rs1650297; rs1677109; rs34268195; rs5796916; rs5796917; rs1478297; rs34667775; rs5796919; rs36050266; rs28424005; rs1616505; rs1650309; rs33984617; rs2126883; rs34439838; rs35336445; rs33930420; rs10716782; rs7298826; rs12307094; rs12308099; rs962946; rs10681437; rs34018310; rs1677113; rs34354944; rs5002144; rs35174029; rs11444668; rs10702414; rs34052790; rs34060682; rs28520103; rs2007049; rs35987638; rs1650311; rs34994333; rs28449925; rs35346295; rs5015840; rs35497937; rs28726969; rs1626023; rs5796918; rs35044122; rs11437489; rs35473871; rs28483251; rs35049167; rs5002142; rs34381931; rs10646800; rs34522871; rs12828206; rs5002143; rs34377909; rs11046146; rs1616506; rs7486051; rs1677081; rs35109393; rs5796915; rs1427830; rs33973125; rs4762862; rs11046144; rs35783676; rs1650285; rs1677136; rs10841865; rs10841867; rs10841868; rs10841869; rs10841872; rs11046153; rs11046154; rs11046159; rs11046160; rs12824788; rs12829701; rs12830306; rs1626167; rs1626303; rs1650277; rs1650278; rs1650279; rs1650280; rs1650282; rs1677090; rs1677091; rs1677092; rs1677093; rs1677094; rs1677096; rs1677098; rs1677100; rs1677141; rs16924082; rs17629491; rs4762714; rs4762856; rs4762857; rs4762858; rs4762859; rs4762863; rs7135965; rs7297042; rs7301852; rs7301883; rs7302639; rs7303528; rs7303612; rs7303644; rs7305475; rs7316427; rs7316475; rs7316669

# Metabolic_Enzyme_5_General_References:
2930497; 3435492; 10508479; 8314553; 8462975; 1587525; 2334429; 8611651; 10211631; 9929983; 11509017

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
8213

# Metabolic_Enzyme_6_Name:
Chymase precursor

# Metabolic_Enzyme_6_Synonyms:
Mast cell protease I

# Metabolic_Enzyme_6_Gene_Name:
CMA1

# Metabolic_Enzyme_6_Protein_Sequence:
>Chymase precursor
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN

# Metabolic_Enzyme_6_Number_of_Residues:
247

# Metabolic_Enzyme_6_Molecular_Weight:
27325

# Metabolic_Enzyme_6_Theoretical_pI:
9.71

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion

# Metabolic_Enzyme_6_Pathway:
Not Available

# Metabolic_Enzyme_6_Reaction:
Preferential cleavage: Phe-|- > Tyr-|- > Trp-|- > Leu-|-

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00089:Trypsin

# Metabolic_Enzyme_6_Signals:
1-19

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.4.21.39

# Metabolic_Enzyme_6_GenBank_ID_Protein:
180542

# Metabolic_Enzyme_6_SwissProt_ID:
CMA1_HUMAN (P23946)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
CMA1

# Metabolic_Enzyme_6_Geneatlas_id:
CMA1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:2097

# Metabolic_Enzyme_6_PDB_ID:
1NN6

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Secreted protein. Cytoplasmic granule. Note=Mast cell granules

# Metabolic_Enzyme_6_Gene_Sequence:
>744 bp
ATGCTGCTTCTTCCTCTCCCCCTGCTGCTCTTTCTCTTGTGCTCCAGAGCTGAAGCTGGG
GAGATCATCGGGGGCACAGAATGCAAGCCACATTCCCGCCCCTACATGGCCTACCTGGAA
ATTGTAACTTCCAACGGTCCCTCAAAATTTTGTGGTGGTTTCCTTATAAGACGGAACTTT
GTGCTGACGGCTGCTCATTGTGCAGGAAGGTCTATAACAGTCACCCTTGGAGCCCATAAC
ATAACAGAGGAAGAAGACACATGGCAGAAGCTTGAGGTTATAAAGCAATTCCGTCATCCA
AAATATAACACTTCTACTCTTCACCACGATATCATGTTACTAAAGTTGAAGGAGAAAGCC
AGCCTGACCCTGGCTGTGGGGACACTCCCCTTCCCATCACAATTCAACTTTGTCCCACCT
GGGAGAATGTGCCGGGTGGCTGGCTGGGGAAGAACAGGTGTGTTGAAGCCGGGCTCAGAC
ACTCTGCAAGAGGTGAAGCTGAGACTCATGGATCCCCAGGCCTGCAGCCACTTCAGAGAC
TTTGACCACAATCTTCAGCTGTGTGTGGGCAATCCCAGGAAGACAAAATCTGCATTTAAG
GGAGACTCTGGGGGCCCTCTTCTGTGTGCTGGGGTGGCCCAGGGCATCGTATCCTATGGA
CGGTCGGATGCAAAGCCCCCTGCTGTCTTCACCCGAATCTCCCATTACCGGCCCTGGATC
AACCAGATCCTGCAGGCAAATTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M64269

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_6_Locus:
14q11.2

# Metabolic_Enzyme_6_SNPs:
rs5247; rs5249; rs1951133; rs1885108; rs2073335; rs12100565; rs10220622; rs10140250; rs5248; rs10135806; rs7153678; rs880678; rs1956923; rs5250; rs1800875; rs5244; rs1956922; rs11623993; rs12892955; rs12893439; rs3759635; rs1800876; rs5245; rs1956920; rs1885110; rs10138131; rs1956921; rs1885109; rs8008222; rs1956924; rs2104080; rs17104478; rs5246; rs13306252; rs13306254; rs7142020; rs13306251; rs13306253; rs35717389; rs5807257; rs8011230; rs34077376; rs10638524; rs2332395; rs2332392; rs34375143; rs8013075; rs2332393; rs12590297; rs5807259; rs2877666; rs34585765; rs34033540; rs2332394; rs5807258; rs34731130; rs4077943; rs35154295; rs36049344; rs2332396; rs11621180; rs11624048; rs12434912; rs12589088; rs17184822; rs17184843; rs1885107; rs1951134; rs1956917; rs1956918; rs1956925; rs1956926; rs1956927; rs1956928; rs1956929; rs1956930; rs1956931; rs1956932; rs1998229; rs1998230; rs2007316; rs2093257; rs2104081; rs2332353; rs2332354; rs34657109; rs4519248; rs4555074; rs4600392; rs4981533; rs4982956; rs6573840; rs7150627; rs7151943; rs7159825; rs8011895; rs911371; rs927278; rs927281

# Metabolic_Enzyme_6_General_References:
2071582; 1894611; 8495723; 2049082; 9400368; 9931257

# Metabolic_Enzyme_6_References:
16959859; 17000864

# Metabolic_Enzyme_7_ID:
8537

# Metabolic_Enzyme_7_Name:
Methylmalonate semialdehyde dehydrogenase precursor

# Metabolic_Enzyme_7_Synonyms:
Not Available

# Metabolic_Enzyme_7_Gene_Name:
MMSADHA

# Metabolic_Enzyme_7_Protein_Sequence:
>Methylmalonate semialdehyde dehydrogenase precursor
RAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPATNEV
IGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQ
GKTLADAEGDVFRG

# Metabolic_Enzyme_7_Number_of_Residues:
134

# Metabolic_Enzyme_7_Molecular_Weight:
14780

# Metabolic_Enzyme_7_Theoretical_pI:
10.43

# Metabolic_Enzyme_7_GO_Classification:
>>>
 Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Energy production and conversion

# Metabolic_Enzyme_7_Specific_Function:
Not Available

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
Not Available

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_7_Signals:
Not Available

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.2.1.27

# Metabolic_Enzyme_7_GenBank_ID_Protein:
2708830

# Metabolic_Enzyme_7_SwissProt_ID:
O43573_HUMAN (O43573)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
MMSADHA

# Metabolic_Enzyme_7_Geneatlas_id:
MMSADHA

# Metabolic_Enzyme_7_hgnc_id:
HGNC:7179

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>401 bp
CGGGCAGTGCGAGCCCGGATCCTGCAGGTTTCTTCCAAGGTGAAATCCAGTCCCACCTGG
TATTCAGCATCTTCCTTCTCTTCTTCAGTGCCAACTGTAAAGCTCTTCATTGGTGGGAAA
TTCGTTGAATCCAAAAGTGACAAATGGATCGATATCCACAACCCAGCCACCAATGAGGTC
ATTGGTCGGGTCCCTCAGGCCACCAAGGCAGAAATGGATGCAGCCATTGCTTCCTGCAAA
CGTGCTTTTCCTGCATGGGCAGACACTTCAGTATTAAGCCGCCAGCAGGTCTTGCTCCGC
TATCAACAACTTATTAAAGAAAACTTGAAAGAAATTGCCAAGTTAATCACATTGGAACAA
GGGAAGACCCTAGCTGATGCTGAAGGAGATGTATTTCGAGG

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AF038011

# Metabolic_Enzyme_7_Chromosome_Location:
Not Available

# Metabolic_Enzyme_7_Locus:
Not Available

# Metabolic_Enzyme_7_SNPs:
Not Available

# Metabolic_Enzyme_7_General_References:
Not Available

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
8834

# Metabolic_Enzyme_8_Name:
CDNA FLJ32499 fis, clone SKNSH2000347, weakly similar to CYTOCHROME B2

# Metabolic_Enzyme_8_Synonyms:
Not Available

# Metabolic_Enzyme_8_Gene_Name:
Not Available

# Metabolic_Enzyme_8_Protein_Sequence:
>CDNA FLJ32499 fis, clone SKNSH2000347, weakly similar to 
CYTOCHROME B2MPRRGLVAGPDLEYFQRRYFTPAEVAQHNRPEDLWVSYLGRVYDLTS
LAQEYKGNLLLKPIVEVAGQDISHWFDPKTRDIRKHIDPLTGCLRYCTPRGRFVHVPPQL
PCSDWANDFGKPWWQGSYYEVGRLSAKTRSIRIINTLTSQEHTLELHVEI

# Metabolic_Enzyme_8_Number_of_Residues:
157

# Metabolic_Enzyme_8_Molecular_Weight:
18308

# Metabolic_Enzyme_8_Theoretical_pI:
8.46

# Metabolic_Enzyme_8_GO_Classification:
Not Available

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
Not Available

# Metabolic_Enzyme_8_Pathway:
map00620  Pyruvate metabolism

# Metabolic_Enzyme_8_Reaction:
(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00173:Cyt-b5

# Metabolic_Enzyme_8_Signals:
Not Available

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.1.2.3

# Metabolic_Enzyme_8_GenBank_ID_Protein:
16552638

# Metabolic_Enzyme_8_SwissProt_ID:
Q96DM7_HUMAN (Q96DM7)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
Not Available

# Metabolic_Enzyme_8_Geneatlas_id:
Not Available

# Metabolic_Enzyme_8_hgnc_id:
HGNC:26516

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Not Available

# Metabolic_Enzyme_8_Gene_Sequence:
>474 bp
ATGCCGCGCCGGGGCCTGGTGGCTGGGCCAGACTTGGAGTATTTTCAGCGTCGCTATTTC
ACGCCGGCGGAGGTGGCCCAACATAACAGGCCCGAAGACCTCTGGGTATCTTACCTGGGA
CGCGTGTACGACCTAACGTCATTGGCACAGGAATACAAGGGGAACCTGCTGCTGAAACCC
ATCGTGGAAGTTGCAGGCCAGGATATCAGCCACTGGTTTGATCCAAAGACCAGAGACATC
CGCAAGCACATAGATCCGCTGACCGGCTGCCTGAGGTACTGCACCCCGCGGGGCCGCTTT
GTGCACGTTCCGCCTCAGCTGCCCTGTTCGGACTGGGCCAACGATTTTGGGAAGCCCTGG
TGGCAGGGGTCGTATTATGAGGTGGGGCGGCTGTCTGCCAAGACCCGGAGCATCCGCATC
ATTAACACGCTCACGTCGCAGGAGCACACACTGGAGCTACACGTGGAAATATGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
AK057061

# Metabolic_Enzyme_8_Chromosome_Location:
Not Available

# Metabolic_Enzyme_8_Locus:
Not Available

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
Not Available

# Metabolic_Enzyme_8_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
6407

# Macromolecular_Interacting_Partner_1_Name:
Monocarboxylate transporter 5

# Macromolecular_Interacting_Partner_1_Synonyms:
MCT 5; MCT 4; Solute carrier family 16 member 4

# Macromolecular_Interacting_Partner_1_Gene_Name:
SLC16A4

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Monocarboxylate transporter 5
MLKREGKVQPYTKTLDGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIG
WIGSIMSSLRFCAGPLVAIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLL
PGLGSAFLYQVAAVVTTKYFKKRLALSTAIARSGMGLTFLLAPFTKFLIDLYDWTGALIL
FGAIALNLVPSSMLLRPIHIKSENNSGIKDKGSSLSAHGPEAHATETHCHETEESTIKDS
TTQKAGLPSKNLTVSQNQSEEFYNGPNRNRLLLKSDEESDKVISWSCKQLFDISLFRNPF
FYIFTWSFLLSQLAYFIPTFHLVARAKTLGIDIMDASYLVSVAGILETVSQIISGWVADQ
NWIKKYHYHKSYLILCGITNLLAPLATTFPLLMTYTICFAIFAGGYLALILPVLVDLCRN
STVNRFLGLASFFAGMAVLSGPPIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFVPLAE
RWKNSLT

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
487

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
54023

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
8.13

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF07690:MFS_1

# Macromolecular_Interacting_Partner_1_Signals:
1-36

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
2463628

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
MOT5_HUMAN (O15374)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
SLC16A4

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
SLC16A4

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:10925

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cell membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1464 bp
ATGCTGAAGAGGGAGGGGAAGGTCCAACCTTACACTAAAACCCTGGATGGAGGATGGGGA
TGGATGATTGTGATTCATTTTTTCCTGGTGAATGTGTTTGTGATGGGGATGACCAAGACT
TTTGCAATTTTCTTTGTGGTCTTTCAAGAAGAGTTTGAAGGCACCTCAGAGCAAATTGGT
TGGATTGGATCCATCATGTCATCTCTTCGTTTTTGTGCAGGTCCCCTGGTTGCTATTATT
TGTGACATACTTGGAGAGAAAACTACCTCCATTCTTGGGGCTTTCGTTGTTACTGGTGGA
TATCTGATCAGCAGCTGGGCCACAAGTATTCCTTTTCTTTGTGTGACTATGGGACTTCTA
CCCGGTTTGGGTTCTGCTTTCTTATACCAAGTGGCTGCTGTGGTAACTACCAAATACTTC
AAAAAACGATTGGCTCTTTCTACAGCTATTGCCCGTTCTGGGATGGGACTGACTTTTCTT
TTGGCACCCTTTACAAAATTCCTGATAGATCTGTATGACTGGACAGGAGCCCTTATATTA
TTTGGAGCTATCGCATTGAATTTGGTGCCTTCTAGTATGCTCTTAAGACCCATCCATATC
AAAAGTGAGAACAATTCTGGTATTAAAGATAAAGGCAGCAGTTTGTCTGCACATGGTCCA
GAGGCACATGCAACAGAAACACACTGCCATGAGACAGAAGAGTCTACCATCAAGGACAGT
ACTACGCAGAAGGCTGGACTACCTAGCAAAAATTTAACAGTCTCACAAAATCAAAGTGAA
GAGTTCTACAATGGGCCTAACAGGAACAGACTGTTATTAAAGAGTGATGAAGAAAGTGAT
AAGGTTATTTCGTGGAGCTGCAAACAACTGTTTGACATTTCTCTCTTTAGAAATCCTTTC
TTCTACATATTTACTTGGTCTTTTCTCCTCAGTCAGTTAGCATACTTCATCCCTACCTTT
CACCTGGTAGCCAGAGCCAAAACACTGGGGATTGACATCATGGATGCCTCTTACCTTGTT
TCTGTAGCAGGTATCCTTGAGACGGTCAGTCAGATTATTTCTGGATGGGTTGCTGATCAA
AACTGGATTAAGAAGTATCATTACCACAAGTCTTACCTCATCCTCTGCGGCATCACTAAC
CTGCTTGCTCCTTTAGCCACCACATTTCCACTACTTATGACCTACACCATCTGCTTTGCC
ATCTTTGCTGGTGGTTACCTGGCATTGATACTGCCTGTACTGGTTGATCTGTGTAGGAAT
TCTACAGTAAACAGGTTTTTGGGACTTGCCAGTTTCTTTGCTGGGATGGCTGTCCTTTCT
GGACCACCTATAGCAGGCTGGTTATATGATTATACCCAGACATACAATGGCTCTTTCTAC
TTCTCTGGCATATGCTATCTCCTCTCTTCAGTTTCCTTTTTTTTTGTACCATTGGCCGAA
AGATGGAAAAACAGTCTGACCTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
U59185

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_1_Locus:
1p13.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs2271885; rs35157487; rs3738750; rs35653868; rs884685; rs884684; rs11120; rs11805148; rs1334882; rs814759; rs2279722; rs2946571; rs7530260; rs3768458; rs4498805; rs6669004; rs4454547; rs2361308; rs12126890; rs6673423; rs722570; rs17025736; rs12410178; rs12403693; rs7556440; rs6658486; rs12028977; rs12062656; rs7545491; rs924250; rs17025692; rs1055013; rs7551977; rs6684293; rs4084434; rs12097823; rs11102094; rs2018177; rs17626812; rs924248; rs12133016; rs12739493; rs12030245; rs11102096; rs6677797; rs17025729; rs11102095; rs2018431; rs7529935; rs1413886; rs17025696; rs7515163; rs10857820; rs10857819; rs11102097; rs6698884; rs3754430; rs12143282; rs12045510; rs12123185; rs17851904; rs11555380; rs1046002; rs4024143; rs34960398; rs34130726; rs34753261; rs3104353; rs35712541; rs34756485; rs1961733; rs1810353; rs12409822; rs34688025; rs3835716; rs11323780; rs35791840; rs4024149; rs34021150; rs35453316; rs35043363; rs12756167; rs35048697; rs35913535; rs3120125; rs12120793; rs3820660; rs34295980; rs35166839; rs3889113; rs17025725; rs34416973; rs12128437; rs2361310; rs12120542; rs4350204; rs36112371; rs2991991; rs34083110; rs12123410; rs34808626; rs35228927; rs6681507; rs5777013; rs4564140; rs35775213; rs10654417; rs35325093; rs12064369; rs11803643; rs35677055; rs3120126; rs10607620; rs12128302; rs35335098; rs3754431; rs28364645; rs33941148; rs11281331; rs11348586; rs11102092; rs11102093; rs11800430; rs12032576; rs12037419; rs12074067; rs12127781; rs12132082; rs12562051; rs12733724; rs17025740; rs4501839

# Macromolecular_Interacting_Partner_1_General_References:
9425115

# Macromolecular_Interacting_Partner_1_References:
16862226; 16959859

# Macromolecular_Interacting_Partner_2_ID:
7549

# Macromolecular_Interacting_Partner_2_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
INS

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_2_Signals:
1-24

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
INS

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_2_Locus:
11p15.5

# Macromolecular_Interacting_Partner_2_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_2_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_2_References:
16873695; 17077346

# Macromolecular_Interacting_Partner_3_ID:
7612

# Macromolecular_Interacting_Partner_3_Name:
Vascular endothelial growth factor A precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
VEGF-A; Vascular permeability factor; VPF

# Macromolecular_Interacting_Partner_3_Gene_Name:
VEGF

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Vascular endothelial growth factor A precursor
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD
IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM
SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPG
PHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
232

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
27043

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
9.08

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00341:PDGF

# Macromolecular_Interacting_Partner_3_Signals:
1-26

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
181971

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
VEGFA_HUMAN (P15692)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
VEGF

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
VEGF

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:12680

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell- associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>576 bp
ATGAACTTTCTGCTGTCTTGGGTGCATTGGAGCCTCGCCTTGCTGCTCTACCTCCACCAT
GCCAAGTGGTCCCAGGCTGCACCCATGGCAGAAGGAGGAGGGCAGAATCATCACGAAGTG
GTGAAGTTCATGGATGTCTATCAGCGCAGCTACTGCCATCCAATCGAGACCCTGGTGGAC
ATCTTCCAGGAGTACCCTGATGAGATCGAGTACATCTTCAAGCCATCCTGTGTGCCCCTG
ATGCGATGCGGGGGCTGCTGCAATGACGAGGGCCTGGAGTGTGTGCCCACTGAGGAGTCC
AACATCACCATGCAGATTATGCGGATCAAACCTCACCAAGGCCAGCACATAGGAGAGATG
AGCTTCCTACAGCACAACAAATGTGAATGCAGACCAAAGAAAGATAGAGCAAGACAAGAA
AATCCCTGTGGGCCTTGCTCAGAGCGGAGAAAGCATTTGTTTGTACAAGATCCGCAGACG
TGTAAATGTTCCTGCAAAAACACAGACTCGCGTTGCAAGGCGAGGCAGCTTGAGTTAAAC
GAACGTACTTGCAGATGTGACAAGCCGAGGCGGTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
M32977

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_3_Locus:
6p12

# Macromolecular_Interacting_Partner_3_SNPs:
Not Available

# Macromolecular_Interacting_Partner_3_General_References:
2479986; 2479987; 1711045; 1791831; 1567395; 9054410; 9878851; 9450968; 10464055; 14574404; 7678805; 2584205; 10067980; 9207067; 9351807; 9922142; 9336848; 9634701; 11427521

# Macromolecular_Interacting_Partner_3_References:
16808811; 16827797

# Macromolecular_Interacting_Partner_4_ID:
6404

# Macromolecular_Interacting_Partner_4_Name:
Monocarboxylate transporter 1

# Macromolecular_Interacting_Partner_4_Synonyms:
MCT 1; Solute carrier family 16 member 1

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC16A1

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Monocarboxylate transporter 1
MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSW
ISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIG
GLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLI
LGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQ
EKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF
LLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYA
GFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYK
YTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKA
AESPDQKDTEGGPKEEESPV

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
500

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
53959

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.82

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  organic acid transporter activity
Function:  carboxylic acid transporter activity
Function:  monocarboxylic acid transporter activity
Function:  monocarboxylate porter activity
Function:  transporter activity
 ||
>>>
Process:  ion transport
Process:  anion transport
Process:  organic anion transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_4_Specific_Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF07690:MFS_1

# Macromolecular_Interacting_Partner_4_Signals:
1-35

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
561722

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
MOT1_HUMAN (P53985)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC16A1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC16A1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:10922

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cell membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1503 bp
ATGCCACCAGCAGTTGGAGGTCCAGTTGGATACACCCCCCCAGATGGAGGCTGGGGCTGG
GCAGTGGTAATTGGAGCTTTCATTTCCATCGGCTTCTCTTATGCATTTCCCAAATCAATT
ACTGTCTTCTTCAAAGAGATTGAAGGTATATTCCATGCCACCACCAGCGAAGTGTCATGG
ATATCCTCCATAATGTTGGCTGTCATGTATGGTGGAGGTCCTATCAGCAGTATCCTGGTG
AATAAATATGGAAGTCGTATAGTCATGATTGTTGGTGGCTGCTTGTCAGGCTGTGGCTTG
ATTGCAGCTTCTTTCTGTAACACCGTACAGCAACTATACGTCTGTATTGGAGTCATTGGA
GGTCTTGGGCTTGCCTTCAACTTGAATCCAGCTCTGACCATGATTGGCAAGTATTTCTAC
AAGAGGCGACCATTGGCCAACGGACTGGCCATGGCAGGCAGCCCTGTGTTCCTCTGTACT
CTGGCCCCCCTCAATCAGGTTTTCTTCGGTATCTTTGGATGGAGAGGAAGCTTTCTAATT
CTTGGGGGCTTGCTACTAAACTGCTGTGTTGCTGGAGCCCTCATGCGACCAATCGGGCCC
AAGCCAACCAAGGCAGGGAAAGATAAGTCTAAAGCATCCCTTGAGAAAGCTGGAAAATCT
GGTGTGAAAAAAGATCTGCATGATGCAAATACAGATCTTATTGGAAGACACCCTAAACAA
GAGAAACGATCAGTCTTCCAAACAATTAATCAGTTCCTGGACTTAACCCTATTCACCCAC
AGAGGCTTTTTGCTATACCTCTCTGGAAATGTGATCATGTTTTTTGGACTCTTTGCACCT
TTGGTGTTTCTTAGTAGTTATGGGAAGAGTCAGCATTATTCTAGTGAGAAGTCTGCCTTC
CTTCTTTCCATTCTGGCTTTTGTTGACATGGTAGCCCGACCATCTATGGGACTTGTAGCC
AACACAAAGCCAATAAGACCTCGAATTCAGTATTTCTTTGCGGCTTCCGTTGTTGCAAAT
GGAGTGTGTCATATGCTAGCACCTTTATCCACTACCTATGTTGGATTCTGTGTCTATGCG
GGATTCTTTGGATTTGCCTTCGGGTGGCTCAGCTCCGTATTGTTTGAAACATTGATGGAC
CTTGTTGGACCCCAGAGGTTCTCCAGCGCTGTGGGATTGGTGACCATTGTGGAATGCTGT
CCTGTCCTCCTGGGGCCACCACTTTTAGGTCGGCTCAATGACATGTATGGAGACTACAAA
TACACATACTGGGCATGTGGCGTCGTCCTAATTATTTCAGGTATCTATCTCTTCATTGGC
ATGGGCATCAATTATCGACTTTTGGCAAAAGAACAGAAAGCAAACGAGCAGAAAAAGGAA
AGTAAAGAGGAAGAGACCAGTATAGATGTTGCTGGGAAGCCAAATGAAGTTACCAAAACA
GCAGAATCTCCGGACCAGAAAGACACAGAAGGAGGGCCCAAGGAGGAGGAAAGTCCAGTC
TGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
L31801

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_4_Locus:
1p12

# Macromolecular_Interacting_Partner_4_SNPs:
rs1049434; rs7169; rs4301628; rs7536532; rs2149036; rs6537765; rs4839272; rs7552903; rs11801876; rs6663872; rs7512840; rs12028967; rs10857983; rs11804107; rs11584410; rs11102566; rs6537764; rs17030801; rs11102567; rs17030816; rs11102568; rs11585690; rs10776763; rs4839270; rs17030813; rs12064292; rs11102565; rs10857982; rs2149035; rs3849174; rs7530614; rs3849175; rs3789592; rs6682142; rs12090418; rs7518984; rs1216536; rs7542229; rs9429505; rs17493313; rs11811205; rs6699036; rs9429504; rs17852383; rs17852382; rs11551865; rs12032912; rs35726266; rs34668228; rs12410450; rs12064619; rs34474294; rs7540353; rs35467660; rs11330109; rs41306207; rs3838296; rs10547445; rs35916708; rs35565232; rs6675400; rs11800050; rs34749109; rs7520741; rs10533734; rs12561835; rs4839271; rs34772905; rs28556822; rs12079494; rs11362773; rs34892510; rs12069981; rs12031658; rs34980299; rs35673011; rs34232032; rs35178977; rs35915464; rs34910611; rs35355323; rs34338318; rs11579784; rs28539939; rs12047151; rs12731926; rs35514037; rs1228254; rs41283088; rs41283086; rs41283090; rs10644465; rs11352959; rs28721419; rs4025829; rs4025918; rs11356817; rs35782087; rs3884279; rs11299752; rs3849176; rs10627911; rs10551131; rs35295062; rs28522572; rs35316620; rs11299751; rs35713403; rs4084029; rs10684892; rs12409576; rs10625158; rs11551866; rs34240603; rs7416738; rs35508455; rs34901627; rs11102562; rs11102564; rs11587120; rs11803365; rs11806554; rs12037621; rs12073146; rs12727968; rs17440299; rs2996394; rs34347074; rs35533332; rs4838971; rs4839273; rs7519199; rs7524567; rs7541119; rs7545316; rs7545602; rs7550843; rs7551223; rs7556664

# Macromolecular_Interacting_Partner_4_General_References:
7835905; 10590411

# Macromolecular_Interacting_Partner_4_References:
16887304; 16959859; 17000864; 17082373

# Macromolecular_Interacting_Partner_5_ID:
8617

# Macromolecular_Interacting_Partner_5_Name:
UEVLD protein

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
UEVLD

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>UEVLD protein
MEFDCEGLRRLLGKYKFRDLTVEELRNVNVFFPHFKYSMDTYGNTYNIPIRFWILDSHPF
APPICFLKPTANMGILVGKHVDAQGRIYLPYLQNWSHPKSVIVGLIKEMIAKFQEELPMY
SLSSSDEARQVDLLAYIAKITEGVSDTNSKSWANHENKTVNKITVVGGGELGIACTLAIS
AKGIADRLVLLDLSEGTKGATMDLEIFNLPNVEISKDLSASAHSKVVIFTVNSLGSSQSY
LDVVQSNVDMFRALVPALGHYSQHSVLLVASQPVEIMTYVTWKLSTFPANRVIGIGCNLD
SQRLQYIITNVLKAQTSGKEVWVIGEQGEDKVLTWSGQEEVVSHTSQVQLSNRDIMI

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
357

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
39778

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.42

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
 Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
 Process:  cellular physiological process
Process:  transport
Process:  protein transport
Process:  ubiquitin cycle
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_5_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00056:Ldh_1_N
PF05743:UEV

# Macromolecular_Interacting_Partner_5_Signals:
Not Available

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
40555769

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
Q6P2F0_HUMAN (Q6P2F0)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
UEVLD

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
UEVLD

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:30866

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1074 bp
ATGGAGTTCGACTGCGAGGGCCTGAGACGGCTGCTTGGCAAGTACAAGTTCAGGGACCTA
ACTGTGGAAGAACTAAGGAATGTAAATGTATTTTTCCCACATTTCAAATATTCCATGGAC
ACCTATGGTAATACATATAACATACCAATTCGTTTCTGGATTTTGGATTCTCACCCTTTC
GCTCCCCCTATTTGCTTCTTGAAGCCAACTGCAAATATGGGAATCTTAGTCGGAAAACAT
GTGGATGCTCAAGGCAGAATATATTTGCCCTATCTCCAAAACTGGAGCCATCCTAAATCT
GTCATTGTTGGATTAATTAAAGAAATGATTGCCAAGTTTCAAGAGGAACTTCCCATGTAT
TCTCTATCATCATCTGATGAGGCACGGCAGGTAGACTTGCTAGCCTATATTGCAAAAATC
ACTGAAGGTGTTTCAGATACAAATTCAAAGAGCTGGGCAAATCATGAGAATAAAACAGTC
AATAAAATTACTGTGGTTGGAGGTGGAGAACTCGGTATTGCCTGCACATTAGCAATTTCA
GCAAAGGGTATTGCAGACAGGCTTGTCCTCTTAGACCTCTCAGAAGGGACTAAAGGAGCC
ACGATGGACCTTGAAATCTTCAACCTTCCTAATGTGGAGATCAGCAAAGATTTGTCTGCC
TCTGCTCATTCCAAGGTGGTGATCTTCACAGTCAACTCTTTGGGTAGTTCTCAGTCGTAC
CTTGATGTGGTACAGAGCAATGTGGATATGTTCAGAGCCCTTGTCCCAGCTCTGGGACAT
TATAGTCAACACAGTGTCCTGCTCGTTGCATCTCAACCAGTGGAAATCATGACCTATGTA
ACATGGAAACTGAGTACATTTCCTGCAAATCGAGTGATCGGAATTGGATGTAATCTGGAT
TCACAGAGATTACAGTATATTATTACAAATGTTTTGAAGGCACAGACTTCAGGCAAAGAA
GTATGGGTTATTGGCGAGCAAGGAGAAGACAAAGTGCTCACATGGAGTGGCCAAGAAGAA
GTAGTGAGTCATACCTCTCAAGTGCAGCTGTCCAACAGGGATATTATGATATAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
BC064566

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_5_Locus:
11p15.1

# Macromolecular_Interacting_Partner_5_SNPs:
rs10500835; rs34242612; rs4756952; rs7950602; rs7107057; rs4756951; rs6486434; rs10832940; rs7105889; rs7109314; rs2305166; rs10741747; rs11024718; rs11024717; rs11024715; rs7928508; rs10766485; rs4756949; rs4756950; rs16935539; rs11024716; rs2271080; rs7942733; rs10741745; rs2271079; rs12577416; rs12420702; rs16935575; rs12577346; rs6486435; rs7119085; rs11024706; rs10832943; rs2305167; rs11822477; rs12577619; rs11024711; rs7951508; rs16935543; rs12418907; rs11024709; rs1857907; rs10219146; rs7952284; rs11024725; rs10832942; rs4757672; rs7130163; rs12224694; rs7101733; rs16935538; rs11024719; rs7108487; rs7483340; rs11024722; rs7109496; rs10832946; rs17392588; rs12420882; rs12225461; rs4756948; rs7102116; rs11825249; rs10219166; rs7940645; rs12421803; rs10741746; rs16935559; rs11024723; rs12419223; rs12225037; rs10832947; rs10832944; rs16935541; rs12803251; rs12418726; rs10766486; rs11024724; rs7107204; rs16935557; rs12049912; rs12289644; rs10832941; rs7116316; rs3781639; rs10832945; rs4623881; rs7106180; rs12289223; rs7926511; rs13377281; rs33991194; rs193330; rs11445836; rs968711; rs12794725; rs35449210; rs10638102; rs11024713; rs34853816; rs12049909; rs11024703; rs34081721; rs34109550; rs35749759; rs12796224; rs33928228; rs3214765; rs4756947; rs34523639; rs7948475; rs12796202; rs28607050; rs4417245; rs12790354; rs11600760; rs10683299; rs12795883; rs35059773; rs12049851; rs7119501; rs35960383; rs7934311; rs968712; rs11024705; rs34474192; rs34736014; rs12790143; rs11024726; rs35798683; rs11024712; rs34170647; rs12807106; rs34286769; rs34951254; rs35410505; rs12792924; rs35715013; rs12280959; rs35038497; rs12225251; rs11449292; rs36022682; rs11024704; rs35032055; rs12278992; rs35875343; rs5790040; rs12795875; rs35900814; rs12223260; rs11024721; rs35864596; rs12226584; rs11024714; rs34120372; rs11600244; rs34327848; rs36054394; rs35906676; rs35944144; rs34900962; rs4757671; rs34888550; rs35110669; rs11394988; rs3837379; rs7116220; rs34434085; rs34297128; rs10540605; rs35315027; rs3832729; rs34999373; rs11024720; rs35047705; rs35274706; rs34545423; rs11602888; rs34585786; rs11603372; rs12574808; rs35702732; rs12421881; rs11302053; rs34139368; rs35384688; rs12804077; rs12290527; rs34587461; rs34646785; rs11443134; rs34386323; rs11602699; rs34857682; rs34561317; rs11024710; rs12222154; rs35537932; rs10734260; rs4757670; rs34226030; rs10444226; rs11024701; rs12287275; rs12785294; rs1395319; rs1395320; rs1530565; rs1547497; rs1857908; rs1857909; rs1979051; rs1983124; rs2088184; rs2121386; rs2174614; rs2292177; rs2292178; rs2292179; rs3802965; rs3802966; rs4436523; rs4757673; rs6416020; rs7931630

# Macromolecular_Interacting_Partner_5_General_References:
12477932

# Macromolecular_Interacting_Partner_5_References:
Not Available

End of HMDB00190

Beginning of HMDB00191
# Accession_No:
HMDB00191

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-19 10:42:04

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
L-Aspartic acid

# Description:
Aspartic acid (Asp, D), also known as aspartate, the name of its anion, is one of the 20 natural proteinogenic amino acids which are the building blocks of proteins. As its name indicates, aspartic acid is the carboxylic acid analog of asparagine. As a neurotransmitter, aspartic acid may provide resistance to fatigue and thus lead to endurance, although the evidence to support this idea is not strong. (http://en.wikipedia.org/wiki/Aspartic_acid) Aspartic acid is a nonessential amino acid which is made from glutamic acid by enzymes using vitamin B6. The amino acid has important roles in the urea cycle and DNA metabolism. Aspartic acid is a major excitatory neurotransmitter, which is sometimes found to be increased in epileptic and stroke patients. It is decreased in depressed patients and in patients with brain atrophy. Aspartic acid supplements are being evaluated. Five grams can raise blood levels. Magnesium and zinc may be natural inhibitors of some of the actions of aspartic acid. Aspartic acid, with the amino acid phenylalanine, is a part of a new natural sweetener, aspartame. This sweetener is an advance in artificial sweeteners, and is probably safe in normal doses to all except phenylketonurics. The jury is still out on the long term effects it has on many brain neurohormones. Aspartic acid may be a significant immunostimulant of the thymus and can protect against some of the damaging effects of radiation. Many claims have been made for the special value of administering aspartic acid in the form of potassium and magnesium salts. Since aspartic acid is relatively nontoxic, studies are now in progress to elucidate its pharmacological and therapeutic roles. (http://www.dcnutrition.com/AminoAcids)

# Synonyms:
(+)-Aspartate; (+)-Aspartic acid; (2S)-Aspartate; (2S)-Aspartic acid; (L)-Aspartate; (L)-Aspartic acid; (R)-2-aminosuccinate; (S)-(+)-Aspartate; (S)-(+)-Aspartic acid; (S)-2-aminosuccinate; (S)-2-aminosuccinic acid; (S)-Aminobutanedioate; (S)-Aminobutanedioic acid; (S)-Aspartate; (S)-Aspartic acid; (S)-amino-Butanedioate; (S)-amino-Butanedioic acid; 2-Amino-3-methylsuccinate; 2-Amino-3-methylsuccinic acid; 2-Aminosuccinate; 2-Aminosuccinic acid; Aminosuccinate;  Asp; Asparagate; Asparagic acid; Asparaginate; Asparaginic acid; Asparatate; Aspartate; H-Asp-OH; L-(+)-Aspartate; L-(+)-Aspartic acid; L-Aminosuccinate; L-Aminosuccinic acid; L-Asparagate; L-Asparagic acid; L-Asparaginate; L-Asparaginic acid; L-Aspartate; alpha-Aminosuccinate; alpha-Aminosuccinic acid

# Chemical_IUPAC_Name:
2-aminobutanedioic acid

# Chemical_Formula:
C4H7NO4

# Chemical_Structure:
tbl_chemical:::HMDB00191_ZOOM.png:::119283242993179924

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00191_THUMB.png:::119283242835421758

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids; Nitrogenous Compounds

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid; alpha-aminoacid

# Taxonomy_Biofunction:
Essential amino acid; Non-essential amino acid; Component of Alanine and aspartate metabolism; Component of Arginine and proline metabolism; Component of Cysteine metabolism; Component of Glutamate metabolism; Component of Histidine metabolism; Component of Nitrogen metabolism; Component of Novobiocin biosynthesis; Component of Phenylalanine metabolism; Component of Phenylalanine, tyrosine and tryptophan biosynthesis; Component of Purine metabolism; Component of Tyrosine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
133.03751

# Molecular_Weight_Avg:
133.10268

# Smiles_String_isomeric:
N[C@@H](CC(O)=O)C(O)=O

# Smiles_String_canonical:
NC(CC(O)=O)C(O)=O

# KEGG_Compound_ID:
C00049

# BioCyc_ID:
L-ASPARTATE

# PubChem_CID:
5960

# PubChem_SID:
3351; 824347; 148792; 7853768; 8153703; 11109885; 6436093; 827788; 739005; 11538459; 8025800; 820604; 11113409; 819467; 10527673; 627127; 819768; 841716; 8144794; 7885984; 834089; 823680; 11538462; 835325; 821992; 770992; 823164; 820598; 10318344; 833956; 830716; 828832; 7847081; 834788; 824125; 824426

# OMIM_ID:
222730; 254960; 600111

# Metagene_ID:
Not Available

# BiGG_ID:
33663

# Wikipedia_ID:
Asp

# METLIN_ID:
5206

# Ref_ID:
16141520; 12297216; 15919887; 14992292; 2195556; 16566829; 11483735; 16309915; 16738792; 14645985; 15967795; 12097436; 15516393; 15284236; 15919888; 6696735; 12834252; 8729530; 12602499; 6198473

# ChEBI_ID:
17053

# CAS_Registry_Number:
56-84-8

# InChI:
InChI=1/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1

# Synthesis_Reference:
Vickery, H.B., Biochem. Prep., 1952, 2, 71-73

# Melting_Point:
270 oC

# Melting_Point_predicted:
38.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
5.39 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]; 14 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
142.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
-3.89 [CHMELIK,J ET AL. (1991)]

# LogP_predicted:
-3.51 [Predicted by ALOGPS]; -3.7 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::L-Aspartic acid.pdf:::1132562214169397599

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::L-Aspartic_acid.mol:::1132723812968195488

# SDF_File_[Text]:
tbl_chemical:::HMDB00191.sdf:::11928324250553572

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00191.pdb:::119283242698992122

# PDB_ID:
1GC4

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041017_P00_02_HW_1DP_Presat.png:::116128936367272939

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041017_P00_02_HW_1DP_Presat.zip:::115644876891328653

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041017_P00_02_HW_1DP_Assigned.png:::116553314067983471

# C_NMR_Spectra:
tbl_cnmr:::041017_P00_02_HW_1DC_30.jpg:::114168460057990626

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041017_P00_02_HW_1DC_30.zip:::114168460055144948

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041017_P00_02_HW_1DC_30_Assigned.jpg:::115920663312131580

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041017_P00_02_HW_2DHSQC_11.jpg:::114616706525290363

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041017_P00_02_HW_2DHSQC_11.zip:::114616706526033538

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041017_P00_02_HW_2DHSQC_11_Assigned.jpg:::116172303043933255

# Predicted_H_NMR_Spectrum:
tbl_chemical:::L-Aspartic acid.gif:::1132732120421166119

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00191_peaks.txt:::1156309607343722078

# Predicted_C_NMR_Spectrum:
tbl_chemical:::L-Aspartic acid_C.gif:::1132737717874110670

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00191_peaks.txt:::1156310796668626015

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00191L.png:::117555261916259864; Medium Energy:tbl_ms:::HMDB00191M.png:::117555267048936469; High Energy:tbl_ms:::HMDB00191H.png:::117555270904837633

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000031.png:::116890823379638931

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000031.txt:::11689082337961236

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000031.png:::116890823351570021

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000031.txt:::116890823379624541

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Urine	4.638 (1.711-7.566)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Blood	21.0 +/- 5.0	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	20.0 +/- 5.0	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	3.0 (2.0-4.0)	umol/L	Adult:>18_yrs_old	Both	Normal	12297216
Cerebrospinal_Fluid(CSF)	2.30 (0.0-4.6)	uM	Adult:>18_yrs_old	Both	Normal	HMP expermental
Cerebrospinal_Fluid(CSF)	2.8 +/- 1.2	umol/L	Adult:>18_yrs_old	Male	Normal	6198473
Cerebrospinal_Fluid(CSF)	1.8 +/- 0.2	umol/L	Adult:>18_yrs_old	Female	Normal	6198473
Cerebrospinal_Fluid(CSF)	0.6 +/- 0.3	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	2.19 +/- 2.63	umol/L	Adult:>18_yrs_old	Both	Normal	12834252
Saliva	>10	umol/L	Adult:>18_yrs_old	Both	Normal	12097436


# Concentration_[Abnormal]:
Blood	36.0 +/- 9.0	umol/L	Adult:>18_yrs_old	Both	Liver disease	12297216
Blood	3.9 (3.7-4.1)	umol/L	Adult:>18_yrs_old	Both	Refractory localization-related epilepsy (RLE)	14992292
Blood	10.0	umol/L	Adult:>18_yrs_old	Both	Diabetes	6696735
Blood	11.8 (10.9-12.7)	umol/L	Adult:>18_yrs_old	Both	Acute seizures	14992292
Cerebrospinal_Fluid(CSF)	0.233 +/- 0.081	umol/L	Adult:>18_yrs_old	N/A	GH Deficiency	8729530


# Associated_Disorders:
Acute seizures; Amyotrophic lateral sclerosis (ALS); Aseptic meningitis; Diabetes; End-stage Renal Disease (ESRD); GH Deficiency; Liver disease; Refractory Localization-Related Epilepsy (RLE); Tuberculous meningitis

# Pathway_Names:
Alanine and aspartate metabolism;Butanoate metabolism;Purine metabolism

# Pathway_Images:
Aspartate_and_Alanine_metabolism.jpg;;Purine_Synthesis.jpg

# KEGG_Images:
map00252;map00650;map00230

# Pathway_Graphs:
Aspartate_and_Alanine_metabolism_Graph.jpg;;Purine_Synthesis_Graph.jpg

# Pathway_SBMLs:
Aspartate_and_Alanine_metabolism.xml;;Purine_Synthesis.xml

# Metabolic_Enzyme_1_ID:
5975

# Metabolic_Enzyme_1_Name:
Glutamate decarboxylase 2

# Metabolic_Enzyme_1_Synonyms:
Glutamate decarboxylase 65 kDa isoform; GAD-65; 65 kDa glutamic acid decarboxylase

# Metabolic_Enzyme_1_Gene_Name:
GAD2

# Metabolic_Enzyme_1_Protein_Sequence:
>Glutamate decarboxylase 2
MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGG
SQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQ
YVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFN
QLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFS
PGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVI
LIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIW
MHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQ
MHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEY
LYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEY
GTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL

# Metabolic_Enzyme_1_Number_of_Residues:
585

# Metabolic_Enzyme_1_Molecular_Weight:
65412

# Metabolic_Enzyme_1_Theoretical_pI:
6.89

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the production of GABA

# Metabolic_Enzyme_1_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00410  beta-Alanine metabolism;
 map00430  Taurine and hypotaurine metabolism;
 map00650  Butanoate metabolism

# Metabolic_Enzyme_1_Reaction:
L-glutamate = 4-aminobutanoate + CO2

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00282:Pyridoxal_deC

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 4.1.1.15

# Metabolic_Enzyme_1_GenBank_ID_Protein:
182934

# Metabolic_Enzyme_1_SwissProt_ID:
DCE2_HUMAN (Q05329)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
GAD2

# Metabolic_Enzyme_1_Geneatlas_id:
GAD2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4093

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm; cytosol. Cytoplasmic vesicle. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters

# Metabolic_Enzyme_1_Gene_Sequence:
>1758 bp
ATGGCATCTCCGGGCTCTGGCTTTTGGTCTTTCGGGTCGGAAGATGGCTCTGGGGATTCC
GAGAATCCCGGCACAGCGCGAGCCTGGTGCCAAGTGGCTCAGAAGTTCACGGGCGGCATC
GGAAACAAACTGTGCGCCCTGCTCTACGGAGACGCCGAGAAGCCGGCGGAGAGCGGCGGG
AGCCAACCCCCGCGGGCCGCCGCCCGGAAGGCCGCCTGCGCCTGCGACCAGAAGCCCTGC
AGCTGCTCCAAAGTGGATGTCAACTACGCGTTTCTCCATGCAACAGACCTGCTGCCGGCG
TGTGATGGAGAAAGGCCCACTTTGGCGTTTCTGCAAGATGTTATGAACATTTTACTTCAG
TATGTGGTGAAAAGTTTCGATAGATCAACCAAAGTGATTGATTTCCATTATCCTAATGAG
CTTCTCCAAGAATATAATTGGGAATTGGCAGACCAACCACAAAATTTGGAGGAAATTTTG
ATGCATTGCCAAACAACTCTAAAATATGCAATTAAAACAGGGCATCCTAGATACTTCAAT
CAACTTTCTACTGGTTTGGATATGGTTGGATTAGCAGCAGACTGGCTGACATCAACAGCA
AATACTAACATGTTCACCTATGAAATTGCTCCAGTATTTGTGCTTTTGGAATATGTCACA
CTAAAGAAAATGAGAGAAATCATTGGCTGGCCAGGGGGCTCTGGCGATGGGATATTTTCT
CCCGGTGGCGCCATATCTAACATGTATGCCATGATGATCGCACGCTTTAAGATGTTCCCA
GAAGTCAAGGAGAAAGGAATGGCTGCTCTTCCCAGGCTCATTGCCTTCACGTCTGAACAT
AGTCATTTTTCTCTCAAGAAGGGAGCTGCAGCCTTAGGGATTGGAACAGACAGCGTGATT
CTGATTAAATGTGATGAGAGAGGGAAAATGATTCCATCTGATCTTGAAAGAAGGATTCTT
GAAGCCAAACAGAAAGGGTTTGTTCCTTTCCTCGTGAGTGCCACAGCTGGAACCACCGTG
TACGGAGCATTTGACCCCCTCTTAGCTGTCGCTGACATTTGCAAAAAGTATAAGATCTGG
ATGCATGTGGATGCAGCTTGGGGTGGGGGATTACTGATGTCCCGAAAACACAAGTGGAAA
CTGAGTGGCGTGGAGAGGGCCAACTCTGTGACGTGGAATCCACACAAGATGATGGGAGTC
CCTTTGCAGTGCTCTGCTCTCCTGGTTAGAGAAGAGGGATTGATGCAGAATTGCAACCAA
ATGCATGCCTCCTACCTCTTTCAGCAAGATAAACATTATGACCTGTCCTATGACACTGGA
GACAAGGCCTTACAGTGCGGACGCCACGTTGATGTTTTTAAACTATGGCTGATGTGGAGG
GCAAAGGGGACTACCGGGTTTGAAGCGCATGTTGATAAATGTTTGGAGTTGGCAGAGTAT
TTATACAACATCATAAAAAACCGAGAAGGATATGAGATGGTGTTTGATGGGAAGCCTCAG
CACACAAATGTCTGCTTCTGGTACATTCCTCCAAGCTTGCGTACTCTGGAAGACAATGAA
GAGAGAATGAGTCGCCTCTCGAAGGTGGCTCCAGTGATTAAAGCCAGAATGATGGAGTAT
GGAACCACAATGGTCAGCTACCAACCCTTGGGAGACAAGGTCAATTTCTTCCGCATGGTC
ATCTCAAACCCAGCGGCAACTCACCAAGACATTGACTTCCTGATTGAAGAAATAGAACGC
CTTGGACAAGATTTATAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M81882

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_1_Locus:
10p11.23

# Metabolic_Enzyme_1_SNPs:
rs2839672; rs2839678; rs1805397; rs2229845; rs7919405; rs1556234; rs3781106; rs8190809; rs1335547; rs3781105; rs3781107; rs8190811; rs8190812; rs8190817; rs8190816; rs8190800; rs8190590; rs8190813; rs8190805; rs8190801; rs7073217; rs8190802; rs8190814; rs8190807; rs8190815; rs8190803; rs992990; rs2368160; rs2368159; rs913963; rs913964; rs1999241; rs870341; rs928197; rs8190604; rs7906725; rs3781109; rs6482551; rs1330581; rs8190764; rs4749108; rs6482541; rs7897510; rs8190780; rs7071922; rs3893052; rs6482537; rs7073119; rs7900739; rs2839671; rs3781108; rs11015008; rs12267286; rs4994426; rs7893400; rs1330582; rs8190754; rs7087663; rs7900976; rs12414701; rs7074534; rs4144102; rs7074235; rs7068224; rs3847380; rs3781113; rs7902107; rs7076544; rs6482540; rs7913676; rs7908975; rs6482550; rs3781117; rs4747548; rs8190748; rs4749105; rs8190706; rs8190704; rs7087011; rs3781114; rs4749101; rs3847378; rs7893194; rs4747550; rs7913524; rs4749102; rs8190798; rs4749107; rs7095327; rs4747547; rs4747549; rs3847379; rs6482538; rs8190598; rs3824694; rs17667367; rs8190658; rs3781111; rs7081084; rs11015015; rs8190694; rs7897355; rs8190734; rs3904297; rs10828963; rs928198; rs913962; rs11015025; rs8190624; rs7099569; rs7918935; rs7072964; rs8190628; rs11015024; rs8190714; rs4749103; rs8190690; rs8190635; rs3781112; rs2839676; rs7909909; rs8190720; rs8190645; rs16926761; rs8190770; rs11594057; rs870342; rs6482544; rs7898281; rs1935996; rs8190708; rs8190716; rs3904298; rs8190597; rs8190779; rs3781116; rs12253114; rs8190660; rs7089304; rs3893253; rs7074934; rs2839675; rs8190796; rs4749104; rs12098763; rs7080514; rs8190685; rs7067571; rs6482543; rs7068510; rs8190611; rs12242971; rs1805398; rs7072137; rs8190689; rs8190646; rs11015010; rs11015028; rs8190718; rs2298124; rs2839674; rs8190713; rs7100268; rs6482548; rs7903208; rs7078680; rs1805399; rs8190678; rs8190701; rs8190612; rs3781118; rs3904296; rs8190637; rs8190683; rs8190673; rs8190782; rs7079102; rs6482542; rs11015004; rs12258601; rs12263667; rs7909902; rs8190620; rs8190650; rs7911425; rs6482547; rs913965; rs8190794; rs8190741; rs8190621; rs7895479; rs1330579; rs8190786; rs8190665; rs8190594; rs8190778; rs8190656; rs16926784; rs8190618; rs8190675; rs8190711; rs8190739; rs7091779; rs8190616; rs8190648; rs8190763; rs8190661; rs11015012; rs8190773; rs12248404; rs8190641; rs8190746; rs8190757; rs8190668; rs12358823; rs8190776; rs8190750; rs8190697; rs11015016; rs7067786; rs8190695; rs8190623; rs12258107; rs6482539; rs8190723; rs8190797; rs8190738; rs8190765; rs8190787; rs7915657; rs7912687; rs12251044; rs10828964; rs8190608; rs8190667; rs8190596; rs16926747; rs8190781; rs8190642; rs8190639; rs8190751; rs8190784; rs8190627; rs3781110; rs8190696; rs8190703; rs12254792; rs8190593; rs8190715; rs8190737; rs8190634; rs8190727; rs10160178; rs12098764; rs8190771; rs8190736; rs8190682; rs2839677; rs8190651; rs8190785; rs11015018; rs4111544; rs7911393; rs10466096; rs7080693; rs11015003; rs8190709; rs7909127; rs7922748; rs8190733; rs11015017; rs8190602; rs8190672; rs8190789; rs3904299; rs8190692; rs8190626; rs8190632; rs8190774; rs11015002; rs12243085; rs8190768; rs8190722; rs8190617; rs7905275; rs8190752; rs8190595; rs8190728; rs1330580; rs7893528; rs11015011; rs12360108; rs8190607; rs8190772; rs8190766; rs8190693; rs8190647; rs7089218; rs6482549; rs10466098; rs8190756; rs8190775; rs8190744; rs7914135; rs12243037; rs12240863; rs8190758; rs8190670; rs7076905; rs12269473; rs8190721; rs8190606; rs8190615; rs8190649; rs2236418; rs3758446; rs4749111; rs8190582; rs2839669; rs2839670; rs4747553; rs4749110; rs7090727; rs4747551; rs7090581; rs4747552; rs2236417; rs8190586; rs1065239; rs8190588; rs8190825; rs8190585; rs8190587; rs8190584; rs8190823; rs2839673; rs8190730; rs8190671; rs8190600; rs8190591; rs8190729; rs8190799; rs8190804; rs34587935; rs41279918; rs8190818; rs1360845; rs8190821; rs17847106; rs8190806; rs8190819; rs8190820; rs8190810; rs8190808; rs2210118; rs35598312; rs35399576; rs8190609; rs8190724; rs11015005; rs11015026; rs8190753; rs8190747; rs11812646; rs11015007; rs8190731; rs16926771; rs34544929; rs8190783; rs8190680; rs8190742; rs7914958; rs11424034; rs34446027; rs10706901; rs8190687; rs8190795; rs8190792; rs12242900; rs7912720; rs12765251; rs8190638; rs17847108; rs35729928; rs35302027; rs8190674; rs28411087; rs36068216; rs11015021; rs12413327; rs41279916; rs8190760; rs3831349; rs35525470; rs8190702; rs12240533; rs8190759; rs7077030; rs35027140; rs8190657; rs8190743; rs35001308; rs35095406; rs8190664; rs35193512; rs8190676; rs7898671; rs34460749; rs7910714; rs8190610; rs8190601; rs11015029; rs34165540; rs10571094; rs34714031; rs17847113; rs8190655; rs10466097; rs8190691; rs34544347; rs8190788; rs34492981; rs11397236; rs8190640; rs8190767; rs34551923; rs11015013; rs12240390; rs17847119; rs958295; rs7896603; rs8190613; rs11351928; rs8190793; rs35560251; rs8190777; rs12258225; rs4749109; rs35466733; rs8190619; rs12764007; rs8190677; rs8190712; rs8190684; rs8190652; rs8190761; rs11015023; rs8190717; rs3925895; rs12780466; rs35967087; rs10691988; rs41279914; rs8190654; rs35473617; rs7906622; rs8190622; rs8190699; rs8190700; rs35554915; rs8190790; rs8190614; rs34282513; rs7904959; rs35460917; rs35692804; rs35701656; rs5783968; rs41304597; rs8190740; rs11015030; rs7910604; rs12258527; rs4749100; rs8190755; rs12265834; rs7906659; rs7911822; rs8190681; rs11382565; rs10550716; rs8190726; rs41304609; rs7900313; rs12258214; rs8190599; rs11015014; rs8190633; rs8190605; rs11594128; rs7084058; rs8190643; rs35046451; rs7897227; rs35449881; rs11015009; rs35322930; rs35856372; rs35871778; rs11389512; rs8190636; rs11437464; rs8190653; rs35327186; rs35218393; rs8190745; rs34436183; rs11015006; rs35900771; rs8190732; rs8190735; rs12252062; rs7074897; rs8190791; rs8190725; rs8190666; rs8190669; rs8190631; rs8190707; rs8190679; rs8190749; rs34964656; rs34166651; rs35778757; rs8190719; rs8190710; rs8190686; rs35829665; rs11407523; rs8190625; rs11417128; rs8190659; rs36008357; rs16926745; rs8190698; rs8190769; rs11014999; rs8190603; rs8190705; rs7078821; rs11015027; rs8190762; rs8190644; rs4589175; rs8190589; rs8190822; rs8190583; rs34861013; rs10508715; rs11014998; rs11015031; rs11015032; rs11591556; rs12248143; rs12256696; rs12264198; rs12265385; rs1330574; rs16926835; rs16926836; rs1888251; rs2150157; rs2150158; rs2150159; rs2150160; rs2839668; rs7899642; rs7915415; rs7922791; rs8190828; rs8190830; rs876845; rs876846; rs876847; rs876848; rs882138; rs994502

# Metabolic_Enzyme_1_General_References:
1924293; 1549570; 8088791; 7680313; 8243826; 8999827; 12356867

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5827

# Metabolic_Enzyme_2_Name:
Aspartoacylase

# Metabolic_Enzyme_2_Synonyms:
Aminoacylase-2; ACY-2

# Metabolic_Enzyme_2_Gene_Name:
ASPA

# Metabolic_Enzyme_2_Protein_Sequence:
>Aspartoacylase
MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK
CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS
NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG
PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA
AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK
LTLNAKSIRCCLH

# Metabolic_Enzyme_2_Number_of_Residues:
313

# Metabolic_Enzyme_2_Molecular_Weight:
35736

# Metabolic_Enzyme_2_Theoretical_pI:
6.51

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids

# Metabolic_Enzyme_2_Pathway:
map00252  Alanine and aspartate metabolism;
 map00340  Histidine metabolism

# Metabolic_Enzyme_2_Reaction:
N-acyl-L-aspartate + H2O = a carboxylate + L-aspartate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF04952:AstE_AspA

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.5.1.15

# Metabolic_Enzyme_2_GenBank_ID_Protein:
455834

# Metabolic_Enzyme_2_SwissProt_ID:
ACY2_HUMAN (P45381)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ASPA

# Metabolic_Enzyme_2_Geneatlas_id:
ASPA

# Metabolic_Enzyme_2_hgnc_id:
HGNC:756

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_2_Gene_Sequence:
>942 bp
ATGACTTCTTGTCACATTGCTGAAGAACATATACAAAAGGTTGCTATCTTTGGAGGAACC
CATGGGAATGAGCTAACCGGAGTATTTCTGGTTAAGCATTGGCTAGAGAATGGCGCTGAG
ATTCAGAGAACAGGGCTGGAGGTAAAACCATTTATTACTAACCCCAGAGCAGTGAAGAAG
TGTACCAGATATATTGACTGTGACCTGAATCGCATTTTTGACCTTGAAAATCTTGGCAAA
AAAATGTCAGAAGATTTGCCATATGAAGTGAGAAGGGCTCAAGAAATAAATCATTTATTT
GGTCCAAAAGACAGTGAAGATTCCTATGACATTATTTTTGACCTTCACAACACCACCTCT
AACATGGGGTGCACTCTTATTCTTGAGGATTCCAGGAATAACTTTTTAATTCAGATGTTT
CATTACATTAAGACTTCTCTGGCTCCACTACCCTGCTACGTTTATCTGATTGAGCATCCT
TCCCTCAAATATGCGACCACTCGTTCCATAGCCAAGTATCCTGTGGGTATAGAAGTTGGT
CCTCAGCCTCAAGGGGTTCTGAGAGCTGATATCTTGGATCAAATGAGAAAAATGATTAAA
CATGCTCTTGATTTTATACATCATTTCAATGAAGGAAAAGAATTTCCTCCCTGCGCCATT
GAGGTCTATAAAATTATAGAGAAAGTTGATTACCCCCGGGATGAAAATGGAGAAATTGCT
GCTATCATCCATCCTAATCTGCAGGATCAAGACTGGAAACCACTGCATCCTGGGGATCCC
ATGTTTTTAACTCTTGATGGGAAGACGATCCCACTGGGCGGAGACTGTACCGTGTACCCC
GTGTTTGTGAATGAGGCCGCATATTACGAAAAGAAAGAAGCTTTTGCAAAGACAACTAAA
CTAACGCTCAATGCAAAAAGTATTCGCTGCTGTTTACATTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
S67156

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_2_Locus:
17pter-p13

# Metabolic_Enzyme_2_SNPs:
rs12948217; rs28940279; rs9896885; rs1873061; rs2131517; rs1488688; rs1493282; rs9902120; rs2035939; rs2029352; rs2029350; rs2035938; rs923376; rs9889588; rs9902229; rs4790496; rs6502727; rs923375; rs11652568; rs9916804; rs11869485; rs2318036; rs9904040; rs9910285; rs4790495; rs8068225; rs3786009; rs7215891; rs2029351; rs12948872; rs11651636; rs9904168; rs9901015; rs9906620; rs8065488; rs17762979; rs2279567; rs11868193; rs6502726; rs8071141; rs6502728; rs3744670; rs11656291; rs17222495; rs8068239; rs16953070; rs3786010; rs12051797; rs8066886; rs17222551; rs8075119; rs9899946; rs12601330; rs1964623; rs12941620; rs12946424; rs9889604; rs16953074; rs1971292; rs35002210; rs17175228; rs7220559; rs9941396; rs11078450; rs3829957; rs11078451; rs3814886; rs28940574; rs17850703; rs1552830; rs35730123; rs10524882; rs12937166; rs3837856; rs5818896; rs34680506; rs36034906; rs9894622; rs36051310; rs3037735; rs2318038; rs34109510; rs12602137; rs11380439; rs35614631; rs12943481; rs8072059; rs12952852; rs35178659; rs2318040; rs34015272; rs2200728; rs2318037; rs8066628; rs8081562; rs34744839; rs12951114; rs35225782; rs12936895; rs35095578; rs35629100; rs34365618; rs36033666; rs34002091; rs2318039; rs34054576; rs3215041; rs12603718; rs34275920; rs12945398; rs5818897; rs36225687; rs6145956; rs8069497; rs3039623; rs10521121; rs11649929; rs11653068; rs11656519; rs11657794; rs12450574; rs12602543; rs12940665; rs12946429; rs16953091; rs17822693; rs34838258; rs3786011; rs4790142; rs4790500; rs7209613; rs7211452; rs7216314; rs7217800; rs7220982; rs7221929; rs7223710; rs8065143; rs8065249; rs8075699; rs8079320; rs9890041

# Metabolic_Enzyme_2_General_References:
8252036; 12706335; 8023850; 7668285; 7599639; 9452117; 10564886; 10909858; 12638939; 12205125

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6162

# Metabolic_Enzyme_3_Name:
Adenylosuccinate synthetase isozyme 2

# Metabolic_Enzyme_3_Synonyms:
Adenylosuccinate synthetase, acidic isozyme; IMP--aspartate ligase 2; AdSS 2; AMPSase 2

# Metabolic_Enzyme_3_Gene_Name:
ADSS

# Metabolic_Enzyme_3_Protein_Sequence:
>Adenylosuccinate synthetase isozyme 2
MAFAETYPAASSLPNGDCGRPRARPGGNRVTVVLGAQWGDEGKGKVVDLLAQDADIVCRC
QGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGL
EGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLR
MCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYE
ALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAY
TTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALAL
TKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKE
LPVNAQNYVRFIEDELQIPVKWIGVGKSRESMIQLF

# Metabolic_Enzyme_3_Number_of_Residues:
456

# Metabolic_Enzyme_3_Molecular_Weight:
50098

# Metabolic_Enzyme_3_Theoretical_pI:
6.52

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  guanyl nucleotide binding
Function:  GTP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  adenylosuccinate synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Plays an important role in the de novo pathway of purine nucleotide biosynthesis

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism;
 map00252  Alanine and aspartate metabolism

# Metabolic_Enzyme_3_Reaction:
GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00709:Adenylsucc_synt

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 6.3.4.4

# Metabolic_Enzyme_3_GenBank_ID_Protein:
415849

# Metabolic_Enzyme_3_SwissProt_ID:
PURA2_HUMAN (P30520)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ADSS

# Metabolic_Enzyme_3_Geneatlas_id:
ADSS

# Metabolic_Enzyme_3_hgnc_id:
HGNC:292

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm. Note=Partially associated with particulate fractions

# Metabolic_Enzyme_3_Gene_Sequence:
>1368 bp
ATGGCGTTCGCCGAGACCTACCCGGCGGCATCCTCCCTGCCCAACGGCGATTGCGGCCGC
CCCAGGGCGGCCGGAGGAAACCGGGTGACGGTGGTGCTCGGTGCGCAGTGGGGCGACGAA
GGCAAAGGGAAGGTGGTGGACCTGCTGGCGCAGGACGCCGACATCGTGTGCCGCTGCCAG
GGAGGAAATAATGCTGGCCATACAGTTGTTGTGGATTCTGTGGAATATGATTTTCATCTC
TTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATT
CATCTACCTGGATTGTTTGAAGAAGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAA
GGCTGGGAAAAAAGGCTTATTATATCTGACAGAGCTCATATTGTATTTGATTTTCATCAA
GCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACA
ACAAAAAAGGGCATTGGCCCAGTTTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATG
TGCGACCTTGTTTCTGACTTTGATGGCTTCTCTGAGAGGTTTAAAGTTCTAGCTAACCAA
TACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAG
GGTTATATGGAAAAGATTAAACCAATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCC
CTACATGGACCACCAAAGAAAATCTTGGTAGAAGGTGCAAATGCAGCACTATTAGATATT
GATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACT
GGTTTGGGTATGCCACCTCAAAATGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACA
ACTAGAGTTGGTATTGGTGCCTTTCCTACAGAGCAAGACAATGAAATTGGAGAATTATTA
CAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTG
GACCTCGTTTTGCTCAAATATGCTCATATGATCAATGGATTTACTGCGTTGGCACTTACC
AAGTTGGATATTTTGGACATGTTTACGGAAATCAAAGTTGGAGTTGCTTACAAGTTAGAT
GGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAA
TATAAGACTCTCCCAGGATGGAACACAGACATATCAAATGCAAGGGCGTTTAAAGAACTA
CCTGTTAATGCACAAAACTATGTTCGATTTATTGAAGATGAGCTTCAAATTCCAGTTAAG
TGGATTGGTGTTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X66503

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_3_Locus:
1cen-q12

# Metabolic_Enzyme_3_SNPs:
rs3087609; rs6702738; rs3003211; rs6661148; rs3127465; rs6686008; rs3006004; rs3101468; rs3101469; rs4132572; rs3127459; rs3102460; rs3123696; rs6695703; rs3127457; rs3003212; rs3003213; rs6429464; rs3127464; rs3127454; rs3123695; rs12408001; rs6679230; rs6699617; rs10927235; rs3127461; rs7521072; rs4658639; rs12087973; rs6684936; rs3123697; rs7545484; rs3127462; rs2306084; rs7539755; rs7545183; rs3006001; rs3127458; rs3127460; rs7539522; rs12569275; rs12410794; rs3127463; rs7527927; rs7517530; rs12047803; rs3102461; rs7551081; rs6677185; rs6685912; rs3124057; rs6666267; rs6669301; rs11801330; rs12042224; rs12041977; rs12408141; rs12045642; rs12087569; rs10927232; rs12145477; rs12402219; rs12032765; rs12116865; rs12071840; rs10927233; rs6685577; rs12563663; rs3127456; rs12080907; rs3124056; rs12128162; rs2068956; rs3006003; rs7518614; rs7540590; rs7518280; rs7518149; rs7529951; rs7532478; rs7530148; rs12134870; rs1131837; rs34994962; rs12085827; rs10653089; rs4306109; rs11434001; rs7525611; rs11355797; rs4132571; rs35783367; rs34529627; rs35132231; rs35033347; rs34327867; rs12024108; rs12023515; rs34764347; rs35232319; rs10593907; rs3127455; rs35495843; rs34487846; rs12026937; rs3003214; rs35199229; rs28429946; rs3006002; rs12734490; rs7546490; rs3214970; rs12408265; rs12027053; rs3003215; rs12754282; rs12724535; rs35190671; rs35133286; rs5782297; rs35946251; rs12021602; rs12129867; rs35213911; rs34630643; rs10652281; rs12754667; rs4658640; rs12097844; rs35147062; rs3127466; rs34361254; rs6667957; rs10692879; rs34075371; rs34914993; rs34710786; rs35629653; rs35944681; rs34063662; rs35548214; rs35275228; rs7540294; rs7518477; rs34801787; rs10927229; rs10927230; rs10927237; rs11579741; rs11580674; rs12084013; rs12136891; rs1237798; rs12404398; rs12404529; rs12730102; rs1601269; rs3006006; rs3102475; rs3124058; rs3127452; rs7524221; rs7524376

# Metabolic_Enzyme_3_General_References:
1592113

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
6166

# Metabolic_Enzyme_4_Name:
Adenylosuccinate synthetase isozyme 1

# Metabolic_Enzyme_4_Synonyms:
IMP--aspartate ligase 1; AdSS 1; AMPSase 1

# Metabolic_Enzyme_4_Gene_Name:
ADSSL1

# Metabolic_Enzyme_4_Protein_Sequence:
>Adenylosuccinate synthetase isozyme 1
MSGTRASNDRPPGAGGVKRGRLQQEAAATGSRVTVVLGAQWGDEGKGKVVDLLATDADII
SRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKG
LKDWEKRLIISDRAHLVFDFHQAVDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTGL
RICDLLSDFDEFSSRFKNLAHQHQSMFPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMY
EALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKA
YTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALA
LTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWE
DLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQLF

# Metabolic_Enzyme_4_Number_of_Residues:
457

# Metabolic_Enzyme_4_Molecular_Weight:
50209

# Metabolic_Enzyme_4_Theoretical_pI:
8.85

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  guanyl nucleotide binding
Function:  GTP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  adenylosuccinate synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Plays an important role in the de novo pathway of purine nucleotide biosynthesis

# Metabolic_Enzyme_4_Pathway:
map00230  Purine metabolism;
 map00252  Alanine and aspartate metabolism

# Metabolic_Enzyme_4_Reaction:
GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00709:Adenylsucc_synt

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 6.3.4.4

# Metabolic_Enzyme_4_GenBank_ID_Protein:
21303413

# Metabolic_Enzyme_4_SwissProt_ID:
PURA1_HUMAN (Q8N142)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
ADSSL1

# Metabolic_Enzyme_4_Geneatlas_id:
ADSSL1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:20093

# Metabolic_Enzyme_4_PDB_ID:
1MF1

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_4_Gene_Sequence:
>1374 bp
ATGTCGGGGACCCGAGCCTCCAACGACCGGCCCCCCGGCGCAGGCGGCGTCAAGCGGGGG
CGGCTGCAGCAGGAGGCGGCGGCGACCGGCTCCCGCGTGACGGTGGTGCTGGGCGCGCAG
TGGGGGGACGAGGGCAAAGGCAAGGTGGTGGACCTGCTGGCCACGGACGCCGACATCATC
AGCCGCTGCCAGGGGGGCAACAACGCCGGCCACACGGTGGTGGTGGATGGGAAAGAGTAC
GACTTCCACCTGCTGCCCAGCGGCATCATCAACACCAAGGCCGTGTCCTTCATTGGCAAC
GGGGTGGTCATCCACTTGCCAGGCTTGTTTGAGGAAGCAGAGAAGAATGAAAAGAAAGGC
CTGAAGGACTGGGAGAAGAGGCTCATCATCTCTGACAGAGCCCACCTTGTGTTTGATTTT
CACCAGGCTGTCGACGGACTTCAGGAAGTGCAGCGCCAGGCACAAGAGGGGAAGAATATA
GGCACCACCAAGAAGGGAATCGGACCAACCTACTCTTCCAAAGCTGCCCGGACAGGCCTC
CGCATCTGCGACCTCCTGTCAGATTTTGATGAGTTTTCCTCCAGATTCAAGAACCTGGCC
CACCAGCACCAGTCGATGTTCCCCACCCTGGAAATAGACATTGAAGGCCAACTCAAAAGG
CTCAAGGGCTTTGCTGAGCGGATCAGACCCATGGTCCGAGATGGTGTTTACTTTATGTAT
GAGGCACTCCACGGCCCCCCCAAGAAGATCCTGGTGGAGGGTGCCAACGCCGCCCTCCTC
GACATTGACTTCGGGACCTACCCCTTTGTGACTTCATCCAACTGCACCGTGGGCGGTGTG
TGCACGGGCCTGGGCATCCCCCCGCAGAACATAGGTGACGTGTATGGCGTGGTGAAAGCC
TATACCACACGTGTGGGCATCGGGGCCTTCCCCACCGAGCAGATCAACGAGATTGGAGGC
CTGCTGCAGACCCGCGGCCACGAGTGGGGAGTGACCACAGGCAGGAAGAGGCGCTGCGGC
TGGCTCGACCTGATGATTCTAAGATATGCTCACATGGTCAACGGATTCACTGCGCTGGCC
CTGACGAAGCTGGACATCCTGGACGTACTGGGTGAGGTTAAAGTCGGTGTCTCATACAAG
CTGAACGGGAAAAGGATTCCCTATTTCCCAGCTAACCAGGAGATGCTTCAGAAGGTCGAA
GTTGAGTATGAAACGCTGCCTGGGTGGAAAGCAGACACCACAGGCGCCAGGAGGTGGGAG
GACCTGCCCCCACAGGCCCAGAACTACATCCGCTTTGTGGAGAATCACGTGGGAGTCGCA
GTCAAATGGGTTGGTGTTGGCAAGTCAAGAGAGTCGATGATCCAGCTGTTTTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AY037159

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_4_Locus:
14q32.33

# Metabolic_Enzyme_4_SNPs:
rs33958252; rs12432802; rs6644; rs10254; rs7141697; rs7142772; rs11848612; rs4983543; rs4983384; rs4247034; rs4983386; rs3803307; rs7149551; rs7149183; rs3803309; rs11844508; rs12587476; rs11848420; rs4983540; rs7160733; rs4983539; rs4983383; rs11850889; rs4983544; rs4983382; rs12883919; rs28410638; rs34672588; rs12894569; rs12887451; rs34272041; rs36104540; rs4432208; rs12885343; rs35455320; rs4587901; rs35825530; rs12881429; rs34802997; rs35614288; rs8011805; rs35023032; rs4307875; rs12885496; rs35746773; rs3803308; rs4983541; rs35590716; rs4983542; rs34420776; rs35712734; rs6576059; rs34550918; rs34673249; rs12878504; rs8004194; rs4983538; rs12886191; rs7155192; rs34936422; rs33917108; rs12896459; rs4591064; rs4983385; rs12896443; rs10623258; rs10653659; rs34022232; rs12589474; rs34879413; rs34979679; rs10150295; rs1128866; rs1128880; rs1132975; rs12433350; rs12587535; rs12587551; rs12590163; rs12590727; rs12881199; rs12892858; rs34055148; rs34251364; rs34642994; rs34877077; rs35550015; rs3803311; rs3809453; rs3809454; rs4247030; rs4247032; rs4247033; rs4351990; rs4983380; rs4983535; rs4983537; rs4983545; rs4983546; rs4983548; rs7155738; rs7156096; rs7157045; rs7161689; rs8006310; rs9672065; rs9783669

# Metabolic_Enzyme_4_General_References:
Not Available

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5516

# Metabolic_Enzyme_5_Name:
Aspartate aminotransferase, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
Transaminase A; Glutamate oxaloacetate transaminase 2

# Metabolic_Enzyme_5_Gene_Name:
GOT2

# Metabolic_Enzyme_5_Protein_Sequence:
>Aspartate aminotransferase, mitochondrial precursor
MALLHSGRVLPGIAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEAFKRDTNSKKM
NLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENSEV
LKSGRFVTVQTISGTGALRIGASFLQRFFKFSRDVFLPKPTWGNHTPIFRDAGMQLQGYR
YYDPKTCGFDFTGAVEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIATVVKKRNLFA
FFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTMVCKDADE
AKRVESQLKILIRPMYSNPPLNGARIAAAILNTPDLRKQWLQEVKGMADRIIGMRTQLVS
NLKKEGSTHNWQHITDQIGMFCFTGLKPEQVERLIKEFSIYMTKDGRISVAGVTSSNVGY
LAHAIHQVTK

# Metabolic_Enzyme_5_Number_of_Residues:
430

# Metabolic_Enzyme_5_Molecular_Weight:
47476

# Metabolic_Enzyme_5_Theoretical_pI:
9.38

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  transaminase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_5_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00272  Cysteine metabolism;
 map00330  Arginine and proline metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00401  Novobiocin biosynthesis;
 map00710  Carbon fixation;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_5_Reaction:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_5_Signals:
1-24

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.6.1.1

# Metabolic_Enzyme_5_GenBank_ID_Protein:
179104

# Metabolic_Enzyme_5_SwissProt_ID:
AATM_HUMAN (P00505)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
GOT2

# Metabolic_Enzyme_5_Geneatlas_id:
GOT2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:4433

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_5_Gene_Sequence:
>1293 bp
ATGGCCCTGCTGCACTCCGGCCGCGTCCTCCCCGGGATCGCCGCCGCCTTCCACCCGGGC
CTCGCCGCCGCGGCCTCTGCCAGAGCCAGCTCCTGGTGGACCCATGTGGAAATGGGACCT
CCAGATCCCATTCTGGGAGTCACTGAAGCCTTTAAGAGGGACACCAATAGCAAAAAGATG
AATCTGGGAGTTGGTGCCTACCGGGATGATAATGGAAAGCCTTACGTTCTGCCTAGCGTC
CGCAAGGCAGAGGCCCAGATTGCCGCAAAAAATTTGGACAAGGAATACCTGCCCATTGGG
GGACTGGCTGAATTTTGCAAGGCATCTGCAGAACTAGCCCTGGGTGAGAACAGCGAAGTC
TTGAAGAGTGGCCGGTTTGTCACTGTGCAGACCATTTCTGGAACTGGAGCCTTAAGGATC
GGAGCCAGTTTTCTGCAAAGATTTTTTAAGTTCAGCCGAGATGTCTTTCTGCCCAAACCA
ACCTGGGGAAACCACACACCCATCTTCAGGGATGCTGGCATGCAGCTACAAGGTTATCGG
TATTATGACCCCAAGACTTGCGGTTTTGACTTCACAGGCGCTGTGGAGGATATTTCAAAA
ATACCAGAGCAGAGTGTTCTTCTTCTGCATGCCTGCGCCCACAATCCCACGGGAGTGGAC
CCGCGTCCGGAACAGTGGAAGGAAATAGCAACAGTGGTGAAGAAAAGGAATCTCTTTGCG
TTCTTTGACATGGCCTACCAAGGCTTTGCCAGTGGTGATGGTGATAAGGATGCCTGGGCT
GTGCGCCACTTCATCGAACAGGGCATTAATGTTTGCCTCTGCCAATCATATGCCAAGAAC
ATGGGCTTATATGGTGAGCGTGTAGGAGCCTTCACTATGGTCTGCAAAGATGCGGATGAA
GCCAAAAGGGTAGAGTCACAGTTGAAGATCTTGATCCGTCCCATGTATTCCAACCCTCCC
CTCAATGGGGCCCGGATTGCTGCTGCCATTCTGAACACCCCAGATTTGCGAAAACAATGG
CTGCAAGAAGTGAAAGGCATGGCTGACCGCATCATTGGCATGCGGACTCAACTGGTCTCC
AACCTCAAGAAGGAGGGTTCCACCCACAATTGGCAACACATCACCGACCAAATTGGCATG
TTCTGTTTCACAGGGCTAAAGCCTGAACAGGTGGAGCGGCTGATCAAGGAGTTCTCCATC
TACATGACAAAAGATGGCCGCATCTCTGTGGCAGGGGTCACCTCCAGCAACGTGGGCTAC
CTTGCCCATGCCATTCACCAGGTCACCAAGTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M22632

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_5_Locus:
16q21

# Metabolic_Enzyme_5_SNPs:
rs30842; rs11076256; rs257636; rs6993; rs7202491; rs11861897; rs257620; rs863944; rs6499971; rs30838; rs30839; rs7204324; rs257616; rs257630; rs1646256; rs8060056; rs6499970; rs30834; rs257617; rs185397; rs257634; rs12600277; rs257618; rs2304490; rs7196291; rs30837; rs9921563; rs1610878; rs4784975; rs9926132; rs257637; rs1646267; rs257631; rs13334922; rs1424245; rs30836; rs190473; rs257633; rs7186087; rs30835; rs173992; rs10500407; rs257649; rs187277; rs9926863; rs40574; rs183757; rs30843; rs1657179; rs7189519; rs1657178; rs2042445; rs7188608; rs257650; rs1803169; rs17849335; rs11558171; rs8059441; rs1058192; rs14221; rs11558167; rs1803168; rs28612351; rs3208672; rs1803170; rs7186105; rs35645687; rs5817158; rs11333258; rs34912264; rs10676089; rs1436429; rs35946557; rs4784974; rs8047219; rs12922626; rs34509416; rs257632; rs35502495; rs12919184; rs7184964; rs9934653; rs9921588; rs4784976; rs13334281; rs9921474; rs12597424; rs7185829; rs13330819; rs28497727; rs34526718; rs7204346; rs3217426; rs11348341; rs34853918; rs257621; rs30840; rs34039790; rs35247174; rs13337034; rs34792826; rs171786; rs30841; rs1657182; rs34180921; rs9923914; rs12921667; rs12933313; rs11299978; rs8046165; rs35323432; rs11423426; rs12932751; rs9933525; rs7186806; rs34289635; rs35324915; rs11439864; rs8046634; rs40575; rs11445492; rs28463297; rs5817159; rs35679170; rs34405351; rs9927670; rs257619; rs35298154; rs3743573; rs8045857; rs9933114; rs8044891; rs35125089; rs35939343; rs7187269; rs257638; rs7194323; rs12923759; rs28472773; rs839418; rs35327432; rs7189104; rs4273028; rs7199783; rs1646260; rs10563758; rs11643959; rs11644269; rs11644290; rs11647748; rs11647808; rs11859875; rs1473205; rs1473206; rs154435; rs1616798; rs1646268; rs3931747; rs4238801; rs4784054; rs4784977; rs6499969; rs7195214; rs7197245

# Metabolic_Enzyme_5_General_References:
3207426; 4052435

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5855

# Metabolic_Enzyme_6_Name:
Asparagine synthetase [glutamine-hydrolyzing]

# Metabolic_Enzyme_6_Synonyms:
Glutamine- dependent asparagine synthetase; Cell cycle control protein TS11

# Metabolic_Enzyme_6_Gene_Name:
ASNS

# Metabolic_Enzyme_6_Protein_Sequence:
>Asparagine synthetase glutaminehydrolyzing
MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRLAVVDPLFGMQ
PIRVKKYPYLWLCYNGEIYNHKKMQQHFEFEYQTKVDGEIILHLYDKGGIEQTICMLDGV
FAFVLLDTANKKVFLGRDTYGVRPLFKAMTEDGFLAVCSEAKGLVTLKHSATPFLKVEPF
LPGHYEVLDLKPNGKVASVEMVKYHHCRDVPLHALYDNVEKLFPGFEIETVKNNLRILFN
NAVKKRLMTDRRIGCLLSGGLDSSLVAATLLKQLKEAQVQYPLQTFAIGMEDSPDLLAAR
KVADHIGSEHYEVLFNSEEGIQALDEVIFSLETYDITTVRASVGMYLISKYIRKNTDSVV
IFSGEGSDELTQGYIYFHKAPSPEKAEEESERLLRELYLFDVLRADRTTAAHGLELRVPF
LDHRFSSYYLSLPPEMRIPKNGIEKHLLRETFEDSNLIPKEILWRPKEAFSDGITSVKNS
WFKILQEYVEHQVDDAMMANAAQKFPFNTPKTKEGYYYRQVFERHYPGRADWLSHYWMPK
WINATDPSARTLTHYKSAVKA

# Metabolic_Enzyme_6_Number_of_Residues:
561

# Metabolic_Enzyme_6_Molecular_Weight:
64371

# Metabolic_Enzyme_6_Theoretical_pI:
6.85

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  asparagine synthase (glutamine-hydrolyzing) activity
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Function:  asparagine synthase (glutamine-hydrolyzing) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aspartate family amino acid metabolism
Process:  asparagine metabolism
Process:  asparagine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate

# Metabolic_Enzyme_6_Pathway:
map00252  Alanine and aspartate metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_6_Reaction:
ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00733:Asn_synthase;
PF00310:GATase_2

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 6.3.5.4

# Metabolic_Enzyme_6_GenBank_ID_Protein:
179100

# Metabolic_Enzyme_6_SwissProt_ID:
ASNS_HUMAN (P08243)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ASNS

# Metabolic_Enzyme_6_Geneatlas_id:
ASNS

# Metabolic_Enzyme_6_hgnc_id:
HGNC:753

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>1686 bp
ATGTGTGGCATTTGGGCGCTGTTTGGCAGTGATGATTGCCTTTCTGTTCAGTGTCTGAGT
GCTATGAAGATTGCACACAGAGGTCCAGATGCATTCCGTTTTGAGAATGTCAATGGATAC
ACCAACTGCTGCTTTGGATTTCACCGGTTGGCGGTAGTTGACCCGCTGTTTGGAATGCAG
CCAATTCGAGTGAAGAAATATCCGTATTTGTGGCTCTGTTACAATGGTGAAATCTACAAC
CATAAGAAGATGCAACAGCATTTTGAATTTGAATACCAGACCAAAGTGGATGGTGAGATA
ATCCTTCATCTTTATGACAAAGGAGGAATTGAGCAAACAATTTGTATGTTGGATGGTGTG
TTTGCATTTGTTTTACTGGATACTGCCAATAAGAAAGTGTTCCTGGGTAGAGATACATAT
GGAGTCAGACCTTTGTTTAAAGCAATGACAGAAGATGGATTTTTGGCTGTATGTTCAGAA
GCTAAAGGTCTTGTTACATTGAAGCACTCCGCGACTCCCTTTTTAAAAGTGGAGCCTTTT
CTTCCTGGACACTATGAAGTTTTGGATTTAAAGCCAAATGGCAAAGTTGCATCCGTGGAA
ATGGTTAAATATCATCACTGTCGGGATGTACCCCTGCACGCCCTCTATGACAATGTGGAG
AAACTCTTTCCAGGTTTTGAGATAGAAACTGTGAAGAACAACCTCAGGATCCTTTTTAAT
AATGCTGTAAAGAAACGTTTGATGACAGACAGAAGGATTGGCTGCCTTTTATCAGGGGGC
TTGGACTCCAGCTTGGTTGCTGCCACTCTGTTGAAGCAGCTGAAAGAAGCCCAAGTACAG
TATCCTCTCCAGACATTTGCAATTGGCATGGAAGACAGCCCCGATTTACTGGCTGCTAGA
AAGGTGGCAGATCATATTGGAAGTGAACATTATGAAGTCCTTTTTAACTCTGAGGAAGGC
ATTCAGGCTCTGGATGAAGTCATATTTTCCTTGGAAACTTATGACATTACAACAGTTCGT
GCTTCAGTAGGTATGTATTTAATTTCCAAGTATATTCGGAAGAACACAGATAGCGTGGTG
ATCTTCTCTGGAGAAGGATCAGATGAACTTACGCAGGGTTACATATATTTTCACAAGGCT
CCTTCTCCTGAAAAAGCCGAGGAGGAGAGTGAGAGGCTTCTGAGGGAACTCTATTTGTTT
GATGTTCTCCGCGCAGATCGAACTACTGCTGCCCATGGTCTTGAACTGAGAGTCCCATTT
CTAGATCATCGATTTTTTTCCTATTACTTGTCTCTGCCACCAGAAATGAGAATTCCAAAG
AATGGGATAGAAAAACATCTCCTGAGAGAGACGTTTGAGGATTCCAATCTGATACCCAAA
GAGATTCTCTGGCGACCAAAAGAAGCCTTCAGTGATGGAATAACTTCAGTTAAGAATTCC
TGGTTTAAGATTTTACAGGAATACGTTGAACATCAGGTTGATGATGCAATGATGGCAAAT
GCAGCCCAGAAATTTCCCTTCAATACTCCTAAAACCAAAGAAGGATATTACTACCGTCAA
GTCTTTGAACGCCATTACCCAGGCCGGGCTGACTGGCTGAGCCATTACTGGATGCCCAAG
TGGATCAATGCCACTGACCCTTCTGCCCGCACGCTGACCCACTACAAGTCAGCTGTCAAA
GCTTAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M27396

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_6_Locus:
7q21.3

# Metabolic_Enzyme_6_SNPs:
rs1049674; rs6465630; rs7800135; rs4727378; rs7790127; rs11486966; rs11771498; rs17345759; rs17169191; rs3735557; rs11767463; rs17169211; rs17169200; rs3832527; rs17169208; rs2237287; rs7810919; rs7781469; rs10253639; rs12704947; rs7792744; rs1017070; rs7811643; rs2074891; rs7797354; rs2394741; rs4729386; rs4727377; rs17169185; rs4729388; rs17279084; rs2237289; rs17344752; rs12113193; rs4568556; rs1986082; rs10486011; rs10263979; rs2302088; rs11768092; rs13239311; rs10278321; rs17169184; rs7779490; rs12669125; rs4634561; rs17345286; rs7810492; rs17131823; rs11773753; rs4729387; rs17169186; rs11976728; rs1974562; rs3757674; rs10447748; rs3757676; rs3757675; rs17169214; rs7803055; rs12670261; rs12672215; rs13224424; rs2070159; rs11554428; rs3179866; rs1803163; rs11554429; rs11554431; rs1049677; rs3735556; rs34050735; rs11554430; rs35467050; rs34856818; rs3832526; rs13227174; rs34170799; rs28525152; rs10261245; rs6959868; rs28505181; rs36063366; rs13437661; rs10231594; rs35910902; rs28393117; rs13240259; rs28681292; rs41278833; rs2237288; rs12704948; rs13227443; rs41278827; rs10281896; rs28576085; rs10277835; rs36021744; rs13227408; rs41278830; rs10261265; rs41278824; rs13227432; rs35525774; rs12671902; rs13227317; rs13227319; rs34781568; rs13235208; rs35358974; rs35190368; rs34980123; rs28568790; rs13237150; rs36101543; rs36145892; rs13311082; rs12668015; rs28675065; rs35939272; rs34857173; rs10486009; rs10486010; rs11975817; rs13230541; rs2530121; rs6966699; rs7798362; rs7800746; rs9641216

# Metabolic_Enzyme_6_General_References:
2886907; 2565875; 12853948; 3470743; 2569668; 2564390; 2573597

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
6176

# Metabolic_Enzyme_7_Name:
Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase

# Metabolic_Enzyme_7_Synonyms:
SAICAR synthetase; Phosphoribosylaminoimidazole carboxylase; AIR carboxylase; AIRC]

# Metabolic_Enzyme_7_Gene_Name:
PAICS

# Metabolic_Enzyme_7_Protein_Sequence:
>Multifunctional protein ADE2 Includes: Phosphoribosylaminoimidazole succinocarboxamide synthase
MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKI
TSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYK
FYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSW
LPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPE
GLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVT
SAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQ
DVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKI
RECNL

# Metabolic_Enzyme_7_Number_of_Residues:
425

# Metabolic_Enzyme_7_Molecular_Weight:
47080

# Metabolic_Enzyme_7_Theoretical_pI:
7.26

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  acid-amino acid ligase activity
Function:  phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
Function:  phosphoribosylaminoimidazole carboxylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
Process:  IMP biosynthesis
Process:  'de novo' IMP biosynthesis
 ||
>>>
Component:  protein complex
Component:  unlocalized protein complex
Component:  phosphoribosylaminoimidazole carboxylase complex

# Metabolic_Enzyme_7_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
ATP + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate

# Metabolic_Enzyme_7_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_7_Reaction:
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00731:AIRC;
PF01259:SAICAR_synt

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 6.3.2.6;EC 4.1.1.21

# Metabolic_Enzyme_7_GenBank_ID_Protein:
28384

# Metabolic_Enzyme_7_SwissProt_ID:
PUR6_HUMAN (P22234)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
PAICS

# Metabolic_Enzyme_7_Geneatlas_id:
PAICS

# Metabolic_Enzyme_7_hgnc_id:
HGNC:8587

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>1278 bp
ATGGCGACAGCTGAGGTACTGAACATTGGTAAAAAATTATATGAGGGTAAAACAAAAGAA
GTCTACGAATTGTTAGACAGTCCAGGAAAAGTCCTCCTGCAGTCCAAGGACCAGATTACA
GCAGGAAATGCAGCTAGAAAAAACCACCTGGAAGGAAAAGCTGCAATCTCAAATAAAATC
ACCAGTTGTATTTTTCAGTTATTACAGGAAGCAGGTATTAAAACTGCCTTCACCAGAAAA
TGTGGGGAGACAGCTTTCATTGCACCGCAGTGTGAAATGATTCCAATTGAATGGGTTTGC
AGAAGAATAGCAACTGGTTCTTTTCTCAAAAGAAATCCTGGTGTCAAGGAAGGATATAAG
TTTTACCCACCTAAAGTGGAGTTGTTTTTCAAGGATGATGCCAATAATGACCCACAGTGG
TCTGAGGAACAGCTGATTGCTGCAAAATTTTGCTTTGCTGGACTTCTTATAGGCCAGACT
GAAGTGGATATCATGAGTCATGCTACACAGGCTATATTTGAAATACTGGAGAAATCCTGG
TTGCCCCAGAATTGTACACTGGTTGATATGAAGATTGAATTTGGTGTTGATGTAACCACC
AAAGAAATTGTTCTTGCTGATGTTATTGACAATGATTCCTGGAGACTCTGGCCATCAGGA
GATCGAAGCCAACAGAAAGACAAACAGTCTTATCGGGACCTCAAAGAAGTAACTCCTGAA
GGGCTCCAAATGGTAAAGAAAAACTTTGAGTGGGTTGCAGAGAGAGTAGAGTTGCTTTTG
AAATCAGAAAGTCAGTGCAGGGTTGTAGTGTTGATGGGCTCTACTTCTGATCTTGGTCAC
TGTGAAAAAATCAAGAAGGCCTGTGGAAATTTTGGCATTCCATGTGAACTTCGAGTAACA
TCTGCGCATAAAGGACCAGATGAAACTCTGAGGATTAAAGCTGAGTATGAAGGGGATGGC
ATTCCTACTGTATTTGTGGCAGTGGCAGGCAGAAGTAATGGTTTGGGACCAGTGATGTCT
GGGAACACTGCATATCCAGTTATCAGCTGTCCTCCCCTCACACCAGACTGGGGAGTTCAG
GATGTGTGGTCTTCTCTTCGACTACCCAGTGGTCTTGGCTGTTCAACCGTACTTTCTCCA
GAAGGATCAGCTCAATTTGCTGCTCAGATATTTGGGTTAAGCAACCATTTGGTATGGAGC
AAACTGCGAGCAAGCATTTTGAACACATGGATTTCCTTGAAGCAGGCTGACAAGAAAATC
AGAGAATGTAATTTATAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
X53793

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_7_Locus:
4q12

# Metabolic_Enzyme_7_SNPs:
rs11549976; rs6584; rs4132099; rs17051687; rs17086785; rs6816268; rs6821301; rs1967559; rs1356787; rs4383672; rs4524447; rs10015221; rs7694047; rs11133442; rs7689163; rs7692073; rs7664841; rs4865102; rs10009543; rs12646703; rs3796550; rs11940993; rs17086773; rs7658340; rs6830518; rs17086776; rs12504291; rs12511770; rs6818715; rs4616819; rs17086769; rs7693436; rs6825812; rs11549977; rs1133210; rs1133207; rs11549974; rs35036637; rs1133213; rs34794824; rs1140982; rs1133212; rs5858382; rs11549968; rs35635848; rs11549967; rs34755867; rs34828932; rs2681325; rs13434512; rs11320390; rs34084823; rs11396759; rs34819396; rs10001639; rs10655972; rs10567266; rs1520024; rs10222686; rs34038051; rs34246908; rs12510712; rs35249885; rs34592124; rs35788109; rs4346704; rs35145560; rs10567265; rs34582745; rs10669543; rs35704478; rs7688482; rs34225999; rs36095150; rs1474179; rs4362880; rs28649329; rs34807983; rs3796549; rs10222713; rs34111955; rs3215284; rs35162427; rs35690402; rs28728250; rs11437374; rs34860174; rs5858381; rs11133443; rs12505749; rs12511049; rs12513091; rs13114104; rs13143904; rs13146014; rs13147824; rs1520025; rs1520026; rs17086786; rs17086793; rs2176786; rs2680757; rs2680758; rs2680759; rs2680760; rs3107324; rs34158519; rs34510373; rs3822001; rs4073691; rs4076320; rs4865101; rs6819534; rs6820922; rs6848187; rs6857233; rs7435941; rs7437329; rs7441274; rs7689891; rs7690278

# Metabolic_Enzyme_7_General_References:
2253271

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
6177

# Metabolic_Enzyme_8_Name:
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase precursor

# Metabolic_Enzyme_8_Synonyms:
Glycosylasparaginase; Aspartylglucosaminidase; N4-(N- acetyl-beta-glucosaminyl-L-asparagine amidase; AGA[Contains: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain]

# Metabolic_Enzyme_8_Gene_Name:
AGA

# Metabolic_Enzyme_8_Protein_Sequence:
>N4betaNacetylglucosaminylLasparaginase precursor
MARKSNLPVLLVPFLLCQALVRCSSPLPLVVNTWPFKNATEAAWRALASGGSALDAVESG
CAMCEREQCD
GSVGFGGSPDELGETTLDAMIMDGTTMDVGAVGDLRRIKNAIGVARKVL
EHTTHTLLVGESATTFAQSMG
FINEDLSTSASQALHSDWLARNCQPNYWRNVIPDPSKY
CGPYKPPGILKQDIPIHKETEDDRGHDTIGMV
VIHKTGHIAAGTSTNGIKFKIHGRVGD
SPIPGAGAYADDTAGAAAATGNGDILMRFLPSYQAVEYMRRGE
DPTIACQKVISRIQKH
FPEFFGAVICANVTGSYGAACNKLSTFTQFSFMVYNSEKNQPTEEKVDCI

# Metabolic_Enzyme_8_Number_of_Residues:
346

# Metabolic_Enzyme_8_Molecular_Weight:
37195

# Metabolic_Enzyme_8_Theoretical_pI:
6.23

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Function:  asparaginase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  glycoprotein metabolism
Process:  glycoprotein catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins

# Metabolic_Enzyme_8_Pathway:
map00511  N-Glycan degradation

# Metabolic_Enzyme_8_Reaction:
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF01112:Asparaginase_2

# Metabolic_Enzyme_8_Signals:
1-23

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.5.1.26

# Metabolic_Enzyme_8_GenBank_ID_Protein:
34760

# Metabolic_Enzyme_8_SwissProt_ID:
ASPG_HUMAN (P20933)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
AGA

# Metabolic_Enzyme_8_Geneatlas_id:
AGA

# Metabolic_Enzyme_8_hgnc_id:
HGNC:318

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_8_Gene_Sequence:
>1041 bp

ATGGCGCGGAAGTCGAACTTGCCTGTGCTTCTCGTGCCGTTTCTGCTCTGCCAGGCCCT
AGTGCGCTGCT
CCAGCCCTCTGCCCCTGGTCGTCAACACTTGGCCCTTTAAGAATGCAA
CCGAAGCAGCGTGGAGGGCATT
AGCATCTGGAGGCTCTGCCCTGGATGCAGTGGAGAGC
GGCTGTGCCATGTGTGAGAGAGAGCAGTGTGAC
GGCTCTGTAGGCTTTGGAGGAAGTCC
TGATGAACTTGGAGAAACCACACTAGATGCCATGATCATGGATG
GCACTACTATGGATG
TAGGAGCAGTAGGAGATCTCAGACGAATTAAAAATGCTATTGGTGTGGCACGGAA
AGTA
CTGGAACATACAACACACACACTTTTAGTAGGAGAGTCAGCCACCACATTTGCTCAAAGT
ATGGGG
TTTATCAATGAAGACTTATCTACCAGTGCTTCTCAAGCTCTTCATTCAGATTG
GCTTGCTCGGAATTGCC
AGCCAAATTATTGGAGGAATGTTATACCAGATCCCTCAAAAT
ACTGCGGACCCTACAAACCACCTGGTAT
CTTAAAGCAGGATATTCCTATCCATAAAGAA
ACAGAAGATGATCGTGGTCATGACACTATTGGCATGGTT
GTAATCCATAAGACAGGACA
TATTGCTGCTGGTACATCTACAAATGGTATAAAATTCAAAATACATGGCC
GTGTAGGAG
ACTCACCAATACCTGGAGCTGGAGCCTATGCTGACGATACTGCAGGGGCAGCCGCAGCCA
C
TGGGAATGGTGATATATTGATGCGCTTCCTGCCAAGCTACCAAGCTGTAGAATACATG
AGAAGAGGAGAA
GATCCAACCATAGCTTGCCAAAAAGTGATTTCAAGAATCCAGAAGCA
TTTTCCAGAATTCTTTGGGGCTG
TTATATGTGCCAATGTGACTGGAAGTTACGGTGCTG
CTTGCAATAAACTTTCAACATTTACTCAGTTTAG
TTTCATGGTTTATAATTCCGAAAAA
AATCAGCCAACTGAGGAAAAAGTGGACTGCATCTAA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X55762

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_8_Locus:
4q32-q33

# Metabolic_Enzyme_8_SNPs:
rs2228119; rs1061814; rs3749479; rs12502301; rs3749478; rs2271101; rs3805167; rs2279932; rs3828487; rs2279931; rs4690523; rs2271100; rs6829436; rs3805166; rs6828154; rs10031429; rs6855346; rs34241758; rs13106192; rs17741109; rs12499096; rs4690522; rs12509908; rs3749480; rs11131798; rs7663996; rs12647375; rs12641389; rs3749481; rs35916166; rs1138833; rs34019119; rs34413111; rs3749477; rs35456322; rs35767469; rs34643578; rs34252987; rs10027395; rs10018500; rs13149149; rs10569017; rs3067063; rs10569015; rs10614782; rs4690385; rs3805165; rs4690521; rs34785542; rs6838643; rs35107911; rs11131799; rs6148810; rs11930929; rs35078952; rs34097231; rs1105059; rs13133517; rs6830102; rs35101180; rs34413069; rs10569016; rs34327660; rs11312963; rs33961765; rs3792607; rs7682705; rs6552234; rs12641323; rs34432452; rs35170289; rs34811693; rs36053602; rs10549132; rs13114941; rs10566991; rs28711280; rs12639945; rs12644019; rs13134494; rs1506808; rs1920959; rs28583254; rs4690517; rs4690518; rs6552236; rs6832968; rs7680586

# Metabolic_Enzyme_8_General_References:
2401370; 2265705; 1840528; 1703489; 1904874; 2011603; 8846222; 1301945; 8776587; 9137882; 11309371

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5830

# Metabolic_Enzyme_9_Name:
Aspartoacylase-2

# Metabolic_Enzyme_9_Synonyms:
Aminoacylase-3; ACY-3; Acylase III; Hepatitis C virus core-binding protein 1; HCBP1

# Metabolic_Enzyme_9_Gene_Name:
ACY3

# Metabolic_Enzyme_9_Protein_Sequence:
>Aspartoacylase2
MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRASFSAVPVLANPAATSG
CRRYVDHDLNRTFTSSFLNSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVLDLHNTTA
NMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKNGLGLELG
PQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPRTEAGHLA
GTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGVAFVQTEK
FTFTVPAMPALTPAPSPAS

# Metabolic_Enzyme_9_Number_of_Residues:
319

# Metabolic_Enzyme_9_Molecular_Weight:
35241

# Metabolic_Enzyme_9_Theoretical_pI:
5.77

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
N-acyl-L-aspartate + H(2)O = a carboxylate + L-aspartate

# Metabolic_Enzyme_9_Pathway:
map00252  Alanine and aspartate metabolism;
 map00340  Histidine metabolism

# Metabolic_Enzyme_9_Reaction:
N-acyl-L-aspartate + H2O = a carboxylate + L-aspartate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF04952:AstE_AspA

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 3.5.1.15

# Metabolic_Enzyme_9_GenBank_ID_Protein:
21654856

# Metabolic_Enzyme_9_SwissProt_ID:
ACY3_HUMAN (Q96HD9)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
ACY3

# Metabolic_Enzyme_9_Geneatlas_id:
ACY3

# Metabolic_Enzyme_9_hgnc_id:
HGNC:24104

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_9_Gene_Sequence:
>960 bp
ATGTGCTCACTGCCTGTGCCCCGGGAGCCCCTGCGTCGCGTGGCTGTGACTGGGGGCACG
CATGGCAACGAGATGTCGGGCGTCTACCTGGCCCGGCACTGGCTGCATGCCCCCGCAGAG
CTGCAGAGAGCCAGCTTCTCCGCTGTGCCTGTGCTGGCCAACCCGGCAGCCACATCCGGC
TGCCGCCGCTACGTGGACCATGACCTCAACCGCACCTTCACCAGCAGCTTCCTCAATTCC
AGGCCCACCCCGGACGACCCATATGAGGTGACAAGAGCCCGAGAGCTGAACCAGCTGCTG
GGGCCCAAGGCCTCGGGCCAGGCCTTTGACTTTGTCCTTGACCTGCACAACACCACGGCC
AACATGGGCACCTGCTTAATCGCGAAGTCCTCCCACGAAGTCTTTGCCATGCACCTGTGC
CGCCATCTGCAGCTGCAGTACCCCGAGCTGTCCTGCCAGGTCTTCCTGTACCAGCGGTCT
GGGGAGGAGAGCTACAACCTGGACTCTGTGGCCAAAAATGGACTGGGTCTGGAGCTGGGC
CCCCAGCCACAGGGTGTGCTGCGGGCTGACATTTTCTCAAGGATGAGGACCCTGGTGGCC
ACAGTTCTGGACTTCATCGAACTCTTCAACCAGGGTACGGCCTTTCCTGCCTTTGAGATG
GAAGCCTATAGACCCGTGGGCGTCGTGGACTTCCCCCGCACCGAGGCCGGGCACCTGGCA
GGCACTGTGCATCCTCAGCTGCAGGACCGAGACTTCCAGCCACTGCAGCCTGGTGCTCCC
ATCTTCCAGATGTTCAGTGGGGAGGACCTGCTCTATGAGGGAGAGTCCACGGTGTACCCC
GTGTTCATTAACGAGGCTGCCTACTATGAGAAGGGCGTTGCCTTTGTCCAGACTGAGAAG
TTCACATTCACCGTGCCTGCCATGCCCGCGCTGACCCCTGCCCCGAGCCCAGCTTCCTAA


# Metabolic_Enzyme_9_GenBank_ID_Gene:
AY040761

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_9_Locus:
11q13.2

# Metabolic_Enzyme_9_SNPs:
rs2290959; rs948445; rs34796596; rs17148450; rs948446; rs2514037; rs2514035; rs3888976; rs2509717; rs2290960; rs1111928; rs2252577; rs2514036; rs2509715; rs2514039; rs2514042; rs2509714; rs2514032; rs2290958; rs2447587; rs2514033; rs948444; rs10736660; rs2514030; rs2252727; rs7127140; rs2509718; rs2509719; rs2514034; rs34667730; rs3029248; rs2361141; rs2361140; rs1871038; rs34786387; rs3029257; rs1871040; rs1871039; rs7108759; rs34976152; rs7108760; rs3029250; rs2514044; rs34146083; rs2509716; rs2514043; rs2361142; rs4520603; rs2514038; rs2361139; rs12281770; rs2447584; rs3029253; rs2514041; rs3029299; rs34783536; rs2250568; rs2361143; rs2447582; rs34359416; rs35110105; rs2447586; rs34892473; rs2514031; rs34790058; rs35512546; rs7108422; rs35960754; rs34968171; rs10716389; rs5792422; rs2514045; rs36075390; rs3029215; rs10160824; rs11378613; rs3029301; rs2054410; rs11378612; rs35317019; rs34917403; rs2447580; rs34428407; rs34190423; rs10896189; rs11227870; rs11227871; rs11607368; rs11820792; rs11828473; rs12274519; rs12288023; rs12363825; rs12421572; rs12787511; rs12799342; rs12800028; rs1317934; rs1993839; rs2054409; rs2126720; rs2447589; rs2447590; rs2447591; rs2447597; rs2509711; rs2509712; rs2509713; rs2509720; rs2514022; rs2514024; rs2514027; rs2514028; rs2514029; rs2885171; rs35212875; rs3758938; rs3758939; rs4608079; rs4930210; rs4930211; rs4930212; rs4930463; rs4930464; rs6591267

# Metabolic_Enzyme_9_General_References:
Not Available

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5515

# Metabolic_Enzyme_10_Name:
Aspartate aminotransferase, cytoplasmic

# Metabolic_Enzyme_10_Synonyms:
Transaminase A; Glutamate oxaloacetate transaminase 1

# Metabolic_Enzyme_10_Gene_Name:
GOT1

# Metabolic_Enzyme_10_Protein_Sequence:
>Aspartate aminotransferase, cytoplasmic
MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQK
IANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFL
ARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLEN
APEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWA
IRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPP
AQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGM
FSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ

# Metabolic_Enzyme_10_Number_of_Residues:
413

# Metabolic_Enzyme_10_Molecular_Weight:
46248

# Metabolic_Enzyme_10_Theoretical_pI:
7.01

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  transaminase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_10_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00272  Cysteine metabolism;
 map00330  Arginine and proline metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00401  Novobiocin biosynthesis;
 map00710  Carbon fixation;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_10_Reaction:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.6.1.1

# Metabolic_Enzyme_10_GenBank_ID_Protein:
179067

# Metabolic_Enzyme_10_SwissProt_ID:
AATC_HUMAN (P17174)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
GOT1

# Metabolic_Enzyme_10_Geneatlas_id:
GOT1

# Metabolic_Enzyme_10_hgnc_id:
HGNC:4432

# Metabolic_Enzyme_10_PDB_ID:
1AJS

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_10_Gene_Sequence:
>1242 bp
ATGGCACCTCCGTCAGTCTTTGCCGAGGTTCCGCAGGCCCAGCCTGTCCTGGTCTTCAAG
CTCACTGCCGACTTCAGGGAGGATCCGGACCCCCGCAAGGTCAACCTGGGAGTGGGAGCA
TATCGCACGGATGACTGCCATCCCTGGGTTTTGCCAGTAGTGAAGAAAGTGGAGCAGAAG
ATTGCTAATGACAATAGCCTAAATCACGAGTATCTGCCAATCCTGGGCCTGGCTGAGTTC
CGGAGCTGTGCTTCTCGTCTTGCCCTTGGGGATGACAGCCCAGCACTCAAGGAGAAGCGG
GTAGGAGGTGTGCAATCTTTGGGGGGAACAGGTGCACTTCGAATTGGAGCTGATTTCTTA
GCGCGTTGGTACAATGGAACAAACAACAAGAACACACCTGTCTATGTGTCCTCACCAACC
TGGGAGAATCACAATGCTGTGTTTTCCGCTGCTGGTTTTAAAGACATTCGGTCCTATCGC
TACTGGGATGCAGAGAAGAGAGGATTGGACCTCCAGGGCTTCCTGAATGATCTGGAGAAT
GCTCCTGAGTTCTCCATTGTTGTCCTCCACGCCTGTGCACACAACCCAACTGGGATTGAC
CCAACTCCGGAGCAGTGGAAGCAGATTGCTTCTGTCATGAAGCACCGGTTTCTGTTCCCC
TTCTTTGACTCAGCCTATCAGGGCTTCGCATCTGGAAACCTGGAGAGAGATGCCTGGGCC
ATTCGCTATTTTGTGTCTGAAGGCTTCGAGTTCTTCTGTGCCCAGTCCTTCTCCAAGAAC
TTCGGGCTCTACAATGAGAGAGTCGGGAATCTGACTGTGGTTGGAAAAGAACCTGAGAGC
ATCCTGCAAGTCCTTTCCCAGATGGAGAAGATCGTGCGGATTACTTGGTCCAATCCCCCC
GCCCAGGGAGCACGAATTGTGGCCAGCACCCTCTCTAACCCTGAGCTCTTTGAGGAATGG
ACAGGTAATGTGAAGACAATGGCTGACCGGATTCTGACCATGAGATCTGAACTCAGGGCA
CGACTAGAAGCCCTCAAAACCCCTGGGACCTGGAACCACATCACTGATCAAATTGGCATG
TTCAGCTTCACTGGGTTGAACCCCAAGCAGGTTGAGTATCTGGTCAATGAAAAGCACATC
TACCTGCTGCCAAGTGGTCGAATCAACGTGAGTGGCTTAACCACCAAAAATCTAGATTAC
GTGGCCACCTCCATCCATGAAGCAGTCACCAAAATCCAGTGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
M37400

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_10_Locus:
10q24.1-q25.1

# Metabolic_Enzyme_10_SNPs:
rs2234971; rs2641; rs11867; rs1126878; rs11190083; rs2862611; rs4328160; rs4919310; rs11813054; rs3793935; rs4919308; rs17111658; rs3750897; rs2275952; rs7906501; rs7918062; rs7067702; rs9971275; rs9971274; rs11190087; rs11594790; rs12571181; rs12249347; rs10883343; rs11819158; rs4353208; rs3763793; rs11190088; rs17569447; rs3793933; rs7921465; rs12253915; rs3793934; rs2494651; rs10883341; rs2862612; rs2490280; rs12768505; rs17111665; rs2862613; rs17569578; rs4567385; rs11815136; rs10883342; rs10748775; rs4919309; rs17491012; rs12253861; rs11190081; rs2862614; rs12217584; rs11815637; rs12766044; rs17111645; rs17111694; rs4919311; rs12411568; rs11557841; rs4564264; rs41290500; rs11557840; rs1126927; rs11190082; rs2642; rs1802509; rs1802508; rs41290498; rs34854950; rs12777843; rs35687189; rs11394746; rs34971146; rs34646712; rs35478605; rs34582301; rs3045656; rs12252840; rs35736782; rs11378738; rs7918037; rs41400447; rs7896693; rs5787336; rs9731375; rs35003844; rs11456562; rs11313874; rs12358477; rs10668892; rs12241455; rs41436049; rs5787337; rs9971276; rs35500142; rs35096443; rs11456561; rs2902275; rs7899976; rs13377085; rs12777646; rs10629267; rs12414885; rs35193236; rs11325628; rs12777641; rs34254460; rs1892505; rs12776735; rs12776369; rs4917866; rs12775973; rs11816599; rs6584274; rs33928164; rs10786543; rs7917808; rs11429814; rs35546038; rs10716499; rs35665184; rs11190090; rs34122561; rs2234894; rs10748774; rs10786545; rs11190080; rs11190094; rs1132364; rs11592057; rs11598504; rs17111699; rs17490682; rs2298315; rs2298316; rs2490281; rs2490283; rs2494652; rs2494653; rs2494654; rs2862610; rs34183428; rs3750896; rs3793931; rs3793932; rs4345898; rs4917862; rs4917864; rs4919307; rs7099391; rs7914408; rs7920356

# Metabolic_Enzyme_10_General_References:
1974457; 2241899

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5928

# Metabolic_Enzyme_11_Name:
Argininosuccinate synthase

# Metabolic_Enzyme_11_Synonyms:
Citrulline--aspartate ligase

# Metabolic_Enzyme_11_Gene_Name:
ASS1

# Metabolic_Enzyme_11_Protein_Sequence:
>Argininosuccinate synthase
MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVF
IEDVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATG
KGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWS
MDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKD
GTTHQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAF
TMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVLKGQVYI
LGRESPLSLYNEELVSMNVQGDYEPTDATGFININSLRLKEYHRLQSKVTAK

# Metabolic_Enzyme_11_Number_of_Residues:
412

# Metabolic_Enzyme_11_Molecular_Weight:
46531

# Metabolic_Enzyme_11_Theoretical_pI:
8.18

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  argininosuccinate synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  urea cycle intermediate metabolism
Process:  arginine metabolism
Process:  arginine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
ATP + L-citrulline + L-aspartate = AMP + diphosphate + omega-N-(L-arginino)succinate

# Metabolic_Enzyme_11_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00252  Alanine and aspartate metabolism;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_11_Reaction:
ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00764:Arginosuc_synth

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 6.3.4.5

# Metabolic_Enzyme_11_GenBank_ID_Protein:
28872

# Metabolic_Enzyme_11_SwissProt_ID:
ASSY_HUMAN (P00966)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
ASS1

# Metabolic_Enzyme_11_Geneatlas_id:
ASS1

# Metabolic_Enzyme_11_hgnc_id:
HGNC:758

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Not Available

# Metabolic_Enzyme_11_Gene_Sequence:
>1239 bp
ATGTCCAGCAAAGGCTCCGTGGTTCTGGCCTACAGTGGCGGCCTGGACACCTCGTGCATC
CTCGTGTGGCTGAAGGAACAAGGCTATGACGTCATTGCCTATCTGGCCAACATTGGCCAG
AAGGAAGACTTCGAGGAAGCCAGGAAGAAGGCACTGAAGCTTGGGGCCAAAAAGGTGTTC
ATTGAGGATGTCAGCAGGGAGTTTGTGGAGGAGTTCATCTGGCCGGCCATCCAGTCCAGC
GCACTGTATGAGGACCGCTACCTCCTGGGCACCTCTCTTGCCAGGCCCTGCATCGCCCGC
AAACAAGTGGAAATCGCCCAGCGGGAGGGGGCCAAGTATGTGTCCCACGGCGCCACAGGA
AAGGGGAACGATCAGGTCCGGTTTGAGCTCAGCTGCTACTCACTGGCCCCCCAGATAAAG
GTCATTGCTCCCTGGAGGATGCCTGAATTCTACAACCGGTTCAAGGGCCGCAATGACCTG
ATGGAGTACGCAAAGCAACACGGGATTCCCATCCCGGTCACTCCCAAGAACCCGTGGAGC
ATGGATGAGAACCTCATGCACATCAGCTACGAGGCTGGAATCCTGGAGAACCCCAAGAAC
CAAGCGCCTCCAGGTCTCTACACGAAGACCCAGGACCCAGCCAAAGCCCCCAACACCCCT
GACATTCTCGAGATCGAGTTCAAAAAAGGGGTCCCTGTGAAGGTGACCAACGTCAAGGAT
GGCACCACCCACCAGACCTCCTTGGAGCTCTTCATGTACCTGAACGAAGTCGCGGGCAAG
CATGGCGTGGGCCGTATTGACATCGTGGAGAACCGCTTCATTGGAATGAAGTCCCGAGGT
ATCTACGAGACCCCAGCAGGCACCATCCTTTACCATGCTCATTTAGACATCGAGGCCTTC
ACCATGGACCGGGAAGTGCGCAAAATCAAACAAGGCCTGGGCTTGAAATTTGCTGAGCTG
GTGTATACCGGTTTACGGCCTAGCCCTGAGTGTGAATTTGTCCGCCACTGCATCGCCAAG
TCCCAGGAGCGAGTGGAAGGGAAAGTGCAGGTGTCCGTCCTCAAGGGCCAGGTGTACATC
CTCGGCCGGGAGTCCCCACTGTCTCTCTACAATGAGGAGCTGGTGAGCATGAACGTGCAG
GGTGATTATGAGCCAACTGATGCCACCGGGTTCATCAACATCAATTCCCTCAGGCTGAAG
GAATATCATCGTCTCCAGAGCAAGGTCACTGCCAAATAG

# Metabolic_Enzyme_11_GenBank_ID_Gene:
X01630

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_11_Locus:
9q34.1

# Metabolic_Enzyme_11_SNPs:
rs10901072; rs877326; rs4740158; rs6597680; rs7040665; rs11243372; rs12554609; rs12004384; rs10901047; rs914983; rs12380009; rs4740435; rs10121847; rs7042129; rs10123082; rs1760275; rs11244382; rs12685110; rs474330; rs553696; rs596317; rs506705; rs602924; rs504752; rs1215983; rs6597499; rs1215971; rs1215980; rs493389; rs543048; rs1215984; rs634432; rs666174; rs914971; rs1215970; rs1653332; rs10901080; rs590086; rs1215979; rs502901; rs666971; rs1215985; rs1215990; rs12555797; rs554629; rs7860909; rs3780588; rs1215986; rs12005118; rs1215972; rs7036163; rs2043189; rs2282219; rs914970; rs480313; rs1215988; rs12551145; rs17147029; rs2991273; rs12375699; rs641510; rs486889; rs7018779; rs17147023; rs506626; rs1215981; rs10114424; rs544701; rs618504; rs11243414; rs4322051; rs548262; rs1615006; rs11789315; rs1215982; rs12340606; rs529569; rs17147021; rs507351; rs1215991; rs7039110; rs7851267; rs1864708; rs1619401; rs652313; rs502166; rs10122141; rs668738; rs476067; rs2043191; rs10901085; rs580228; rs1215978; rs2043190; rs12003032; rs12553162; rs17147018; rs1215940; rs566037; rs640181; rs7847222; rs12000999; rs1760253; rs12343715; rs1215975; rs11243474; rs12377651; rs1215987; rs7040689; rs1215976; rs584157; rs4032; rs540140; rs4740430; rs928518; rs7854616; rs688430; rs35269064; rs11549769; rs1057484; rs35772983; rs3208841; rs2297599; rs13440219; rs13290196; rs35463800; rs11243377; rs12685093; rs3012668; rs35902422; rs5900898; rs11272909; rs3085579; rs10121464; rs28534724; rs11337242; rs28511880; rs13293193; rs35000413; rs5900899; rs12340634; rs41296095; rs35487019; rs1215977; rs35835384; rs34768057; rs3780589; rs34339017; rs11243481; rs34029710; rs34271203; rs11271310; rs11243542; rs13301636; rs12171726; rs34273046; rs4740317; rs35512453; rs1653340; rs34362653; rs34654848; rs1653334; rs11243500; rs35852270; rs12376592; rs35568745; rs12343078; rs11243395; rs28440121; rs34248043; rs12378416; rs1215941; rs12375712; rs28665572; rs11243405; rs35797527; rs4740239; rs2313201; rs884804; rs3030699; rs34037515; rs35769425; rs34790521; rs1215989; rs35976100; rs35015356; rs2297598; rs10114733; rs6151195; rs41302903; rs928517; rs12344308; rs2915535; rs28634784; rs35889473; rs884803; rs35476109; rs34850609; rs596698; rs13288900; rs34421800; rs35943966; rs534737; rs28530182; rs2116393; rs11243400; rs35581111; rs12553789; rs28633982; rs4740161; rs34599158; rs35204727; rs631908; rs13288740; rs7025952; rs1467802; rs11788148; rs35842179; rs11243523; rs11243545; rs7030804; rs34149601; rs7855232; rs35220375; rs28587006; rs11244367; rs12352216; rs11244364; rs7043097; rs34734822; rs36233815; rs2071367; rs35688375; rs10793902; rs10901110; rs11244343; rs12236605; rs12337532; rs12342208; rs12345660; rs2313079; rs3087691; rs4237122; rs7041914; rs7851772; rs7865294; rs7869828; rs928516

# Metabolic_Enzyme_11_General_References:
6194510; 6321498; 11941481; 2788888; 9150948; 2358466; 1943692; 7977368; 8792870; 11708871; 12815590

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5976

# Metabolic_Enzyme_12_Name:
Glutamate decarboxylase 1

# Metabolic_Enzyme_12_Synonyms:
Glutamate decarboxylase 67 kDa isoform; GAD-67; 67 kDa glutamic acid decarboxylase

# Metabolic_Enzyme_12_Gene_Name:
GAD1

# Metabolic_Enzyme_12_Protein_Sequence:
>Glutamate decarboxylase 1
MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEK
SRLVSAFKERQSSKNLLSCENSDRDARFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEV
VDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGV
RTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWS
SKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTSEQSHYSIKKAGAA
LGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDPIQEIA
DICEKYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKE
KGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQI
NKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAP
KIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL

# Metabolic_Enzyme_12_Number_of_Residues:
594

# Metabolic_Enzyme_12_Molecular_Weight:
66897

# Metabolic_Enzyme_12_Theoretical_pI:
7.67

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-carbon lyase activity
Function:  carboxy-lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_12_Specific_Function:
Catalyzes the production of GABA

# Metabolic_Enzyme_12_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00410  beta-Alanine metabolism;
 map00430  Taurine and hypotaurine metabolism;
 map00650  Butanoate metabolism

# Metabolic_Enzyme_12_Reaction:
L-glutamate = 4-aminobutanoate + CO2

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00282:Pyridoxal_deC

# Metabolic_Enzyme_12_Signals:
None

# Metabolic_Enzyme_12_Transmembrane_Regions:
None

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 4.1.1.15

# Metabolic_Enzyme_12_GenBank_ID_Protein:
182936

# Metabolic_Enzyme_12_SwissProt_ID:
DCE1_HUMAN (Q99259)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
GAD1

# Metabolic_Enzyme_12_Geneatlas_id:
GAD1

# Metabolic_Enzyme_12_hgnc_id:
HGNC:4092

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Not Available

# Metabolic_Enzyme_12_Gene_Sequence:
>1785 bp
ATGGCGTCTTCGACCCCATCTTCGTCCGCAACCTCCTCGAACGCGGGAGCGGACCCCAAT
ACCACTAACCTGCGCCCCACAACGTACGATACCTGGTGCGGCGTGGCCCATGGATGCACC
AGAAAACTGGGGCTCAAGATCTGCGGCTTCTTGCAAAGGACCAACAGCCTGGAAGAGAAG
AGTCGCCTTGTGAGTGCCTTCAGGGAGAGGCAATCCTCCAAGAACCTGCTTTCCTGTGAA
AACAGCGACCGGGATGCCCGCTTCCGGCGCACAGAGACTGACTTCTCTAATCTGTTTGCT
AGAGATCTGCTTCCGGCTAAGAACGGTGAGGAGCAAACCGTGCAATTCCTCCTGGAAGTG
GTGGACATACTCCTCAACTATGTCCGCAAGACATTTGATCGCTCCACCAAGGTGCTGGAC
TTTCATCACCCACACCAGTTGCTGGAAGGCATGGAGGGCTTCAACTTGGAGCTCTCTGAC
CACCCCGAGTCCCTGGAGCAGATCCTGGTTGACTGCAGAGACACCTTGAAGTATGGGGTT
CGCACAGGTCATCCTCGATTTTTCAACCAGCTCTCCACTGGATTGGATATTATTGGCCTA
GCTGGAGAATGGCTGACATCAACGGCCAATACCAACATGTTTACATATGAAATTGCACCA
GTGTTTGTCCTCATGGAACAAATAACACTTAAGAAGATGAGAGAGATAGTTGGATGGTCA
AGTAAAGATGGTGATGGGATATTTTCTCCTGGGGGCGCCATATCCAACATGTACAGCATC
ATGGCTGCTCGCTACAAGTACTTCCCGGAAGTTAAGACAAAGGGCATGGCGGCTGTGCCT
AAACTGGTCCTCTTCACCTCAGAACAGAGTCACTATTCCATAAAGAAAGCTGGGGCTGCA
CTTGGCTTTGGAACTGACAATGTGATTTTGATAAAGTGCAATGAAAGGGGGAAAATAATT
CCAGCTGATTTTGAGGCAAAAATTCTTGAAGCCAAACAGAAGGGATATGTTCCCTTTTAT
GTCAATGCAACTGCTGGCACGACTGTTTATGGAGCTTTTGATCCGATACAAGAGATTGCA
GATATATGTGAGAAATATAACCTTTGGTTGCATGTCGATGCTGCCTGGGGAGGTGGGCTG
CTCATGTCCAGGAAGCACCGCCATAAACTCAACGGCATAGAAAGGGCCAACTCAGTCACC
TGGAACCCTCACAAGATGATGGGCGTGCTGTTGCAGTGCTCTGCCATTCTCGTCAAGGAA
AAGGGTATACTCCAAGGATGCAACCAGATGTGTGCAGGATATCTCTTCCAGCCAGACAAG
CAGTATGATGTCTCCTACGACACCGGGGACAAGGCAATTCAGTGTGGCCGCCACGTGGAT
ATCTTCAAGTTCTGGCTGATGTGGAAAGCAAAGGGCACAGTGGGATTTGAAAACCAGATC
AACAAATGCCTGGAACTGGCTGAATACCTCTATGCCAAGATTAAAAACAGAGAAGAATTT
GAGATGGTTTTCAATGGCGAGCCTGAGCACACAAACGTCTGTTTTTGGTATATTCCACAA
AGCCTCAGGGGTGTGCCAGACAGCCCTCAACGACGGGAAAAGCTACACAAGGTGGCTCCA
AAAATCAAAGCCCTGATGATGGAGTCAGGTACGACCATGGTTGGCTACCAGCCCCAAGGG
GACAAGGCCAACTTCTTCCGGATGGTCATCTCCAACCCAGCCGCTACCCAGTCTGACATT
GACTTCCTCATTGAGGAGATAGAAAGACTGGGCCAGGATCTGTAA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
M81883

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_12_Locus:
2q31

# Metabolic_Enzyme_12_SNPs:
rs769402; rs769403; rs41526346; rs769401; rs11542313; rs769395; rs2270335; rs769399; rs3749034; rs1049730; rs3762553; rs769406; rs769409; rs2058725; rs769391; rs769411; rs3791861; rs3791856; rs2270334; rs701492; rs4668331; rs3791857; rs769393; rs3791875; rs3791853; rs3791876; rs2302659; rs3791877; rs769390; rs3791862; rs10439259; rs2234728; rs4668329; rs2241164; rs3791860; rs7561581; rs3791850; rs6716794; rs3791865; rs3791858; rs2241165; rs3791851; rs7578661; rs3828275; rs6433253; rs16858977; rs3791866; rs16858988; rs6433252; rs3749033; rs34210682; rs12612498; rs769405; rs3791871; rs4668330; rs11900444; rs11896169; rs769408; rs3791874; rs3791859; rs4668327; rs41464547; rs41393845; rs1420385; rs1548902; rs41496949; rs1477061; rs11896015; rs701491; rs3791864; rs3791872; rs10930441; rs11890416; rs10191129; rs11895404; rs769407; rs3791855; rs2234727; rs11890409; rs3762556; rs3791878; rs6755370; rs3762557; rs3749035; rs3791879; rs6755371; rs3791880; rs2356236; rs3762554; rs4668324; rs872124; rs3762555; rs1049731; rs1049736; rs17857149; rs17857148; rs1049735; rs34856125; rs34100397; rs1049733; rs1049734; rs35426017; rs3049870; rs5836306; rs34510522; rs34365430; rs35367730; rs35542409; rs954947; rs17752543; rs13017667; rs35495756; rs3791868; rs10698625; rs3049892; rs11338558; rs11331088; rs41265947; rs3791852; rs13035478; rs769394; rs35089719; rs13018052; rs3838551; rs34072956; rs2160415; rs769389; rs34265473; rs13385854; rs2160414; rs11338557; rs34462898; rs13014614; rs35050499; rs3791867; rs4668332; rs13017665; rs3828274; rs35232338; rs34347776; rs13000989; rs35659093; rs4668325; rs10698618; rs34528852; rs3791873; rs7602684; rs12995992; rs35050304; rs6753612; rs35212610; rs10179059; rs35492651; rs3838552; rs7576933; rs41304175; rs34884445; rs10529529; rs13028093; rs35845895; rs41315874; rs28514878; rs3749032; rs3791854; rs35445717; rs769398; rs5836308; rs12991140; rs13014984; rs13033900; rs3791869; rs11333718; rs3791863; rs10605864; rs7594314; rs4667661; rs34291719; rs3791870; rs11314645; rs35495071; rs769410; rs4536622; rs10623405; rs35403424; rs4668326; rs3838550; rs10930442; rs3838553; rs35991368; rs4668328; rs13014595; rs7595288; rs11327360; rs35566565; rs35379843; rs41311313; rs5836305; rs1362492; rs4667659; rs3762558; rs4667660; rs6755102; rs6758358; rs33918896; rs34236419; rs10803852; rs10930443; rs11682957; rs11694200; rs11904485; rs12185692; rs12472230; rs12614879; rs12999141; rs13432752; rs16858996; rs17701824; rs1978340; rs2160413; rs2192987; rs28642888; rs3762560; rs3762561; rs4389303; rs4667662; rs4667663; rs6433254; rs6433255; rs6433256; rs6433257; rs6433261; rs6755814; rs7564761; rs7577421

# Metabolic_Enzyme_12_General_References:
1549570; 8088791; 1339255; 8507202; 8507203; 10671565; 2039509; 1697032

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
8876

# Metabolic_Enzyme_13_Name:
CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase

# Metabolic_Enzyme_13_Synonyms:
Not Available

# Metabolic_Enzyme_13_Gene_Name:
CAD

# Metabolic_Enzyme_13_Protein_Sequence:
>CAD protein Includes: Glutaminedependent carbamoylphosphate synthase
MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNY
GIPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVD
TRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILA
LDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVL
SEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVE
TDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEA
TAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAI
KALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQT
ALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQ
AQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEI
EYEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQTLNDREYQLLRQTAIKVTQHLG
IVGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRN
SVTGGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKAL
RMVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRM
KRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAV
KQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQ
QLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLP
NNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQT
VGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAV
ASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFN
LQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVG
VKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIG
SYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSI
LEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEAL
GQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMV
CAMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLN
ETFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEE
ILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVI
DCFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIF
HLPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVL
VPPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASD
PGLPAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHS
LVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSF
AAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRR
PVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVS
LRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEA
CFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLAT
VLGRF

# Metabolic_Enzyme_13_Number_of_Residues:
2225

# Metabolic_Enzyme_13_Molecular_Weight:
242987

# Metabolic_Enzyme_13_Theoretical_pI:
6.42

# Metabolic_Enzyme_13_GO_Classification:
>>>
 Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  carbamoyl-phosphate synthase activity
Function:  aspartate carbamoyltransferase activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  carboxyl- and carbamoyltransferase activity
Function:  binding
Function:  amine binding
Function:  amino acid binding
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
 Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
Process:  urea cycle intermediate metabolism
Process:  arginine metabolism
Process:  arginine biosynthesis
Process:  nitrogen compound metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  pyrimidine base metabolism
Process:  pyrimidine base biosynthesis
Process:  'de novo' pyrimidine base biosynthesis
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
 Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_13_General_Function:
Amino acid transport and metabolism

# Metabolic_Enzyme_13_Specific_Function:
This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase)

# Metabolic_Enzyme_13_Pathway:
map00240  Pyrimidine metabolism
 map00251  Glutamate metabolism

# Metabolic_Enzyme_13_Reaction:
2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF01979:Amidohydro_1
PF00289:CPSase_L_chain
PF02786:CPSase_L_D2
PF02787:CPSase_L_D3
PF00988:CPSase_sm_chain
PF00117:GATase
PF02142:MGS
PF00185:OTCace
PF02729:OTCace_N

# Metabolic_Enzyme_13_Signals:
Not Available

# Metabolic_Enzyme_13_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 6.3.5.5;EC 2.1.3.2;EC 3.5.2.3

# Metabolic_Enzyme_13_GenBank_ID_Protein:
1228049

# Metabolic_Enzyme_13_SwissProt_ID:
PYR1_HUMAN (P27708)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
CAD

# Metabolic_Enzyme_13_Geneatlas_id:
CAD

# Metabolic_Enzyme_13_hgnc_id:
HGNC:1424

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_13_Gene_Sequence:
>6678 bp
ATGGCGGCCCTAGTGTTGGAGGACGGGTCGGTCCTGCGGGGCCAGCCCTTTGGGGCCGCC
GTGTCGACTGCCGGGGAAGTGGTGTTTCAAACCGGCATGGTCGGCTACCCCGAGGCCCTC
ACTGATCCCTCCTACAAGGCACAGATCTTAGTGCTCACCTATCCTCTGATCGGCAACTAT
GGCATCCCCCCAGATGAAATGGATGAGTTCGGTCTCTGCAAGTGGTTTGAATCCTCGGGC
ATCCACGTAGCAGCACTGGTAGTGGGAGAGTGCTGTCCTACTCCCAGCCACTGGAGTGCC
ACCCGCACCCTGCATGAGTGGCTGCAGCAGCATGGCATCCCTGGCTTGCAAGGAGTAGAC
ACTCGGGAGCTGACCAAGAAGTTGCGGGAACAGGGGTCTCTGCTGGGGAAGCTGGTCCAG
AATGGAACAGAACCTTCATCCCTGCCATTCTTGGACCCCAATGCCCGCCCCCTGGTACCA
GAGGTCTCCATTAAGACTCCACGGGTATTCAATACAGGGGGTGCCCCTCGGATCCTTGCT
TTGGACTGTGGCCTCAAGTATAATCAGATCCGATGCCTCTGCCAGCGTGGGGCTGAGGTC
ACTGTGGTACCCTGGGACCATGCACTAGACAGCCAAGAGTATGAGGGTCTCTTCTTAAGT
AATGGGCCTGGTGACCCTGCCTCCTATCCCAGTGTCGTATCCACACTGAGCCGTGTTTTA
TCTGAGCCTAATCCCCGACCTGTCTTTGGGATCTGCCTGGGACACCAGCTATTGGCCTTA
GCCATTGGGGCCAAGACTTACAAGATGAGATATGGGAACCGAGGCCATAACCAGCCCTGC
TTGTTGGTGGGCTCTGGGCGCTGCTTTCTGACATCCCAGAACCATGGGTTTGCTGTGGAG
ACAGACTCACTGCCAGCAGACTGGGCTCCTCTCTTCACCAACGCCAATGATGGTTCCAAT
GAAGGCATTGTGCACAACAGCTTGCCTTTCTTCAGTGTCCAGTTTCACCCAGAGCACCAA
GCTGGCCCTTCAGATATGGAACTGCTTTTCGATATCTTTCTGGAAACTGTGAAAGAGGCC
ACAGCTGGGAACCCTGGGGGCCAGACAGTTAGAGAGCGGCTGACTGAGCGCCTCTGTCCC
CCTGGGATTCCCACTCCCGGCTCTGGACTTCCACCACCACGAAAGGTTCTGATCCTGGGC
TCAGGGGGCCTCTCCATTGGCCAAGCTGGAGAATTTGACTACTCGGGCTCTCAGGCAATT
AAGGCCCTGAAGGAGGAAAACATCCAGACGTTGCTGATCAACCCCAATATTGCCACAGTG
CAGACCTCCCAGGGGCTGGCCGACAAGGTCTATTTTCTTCCCATAACACCTCATTATGTA
ACCCAGGTGATACGTAATGAACGCCCCGATGGTGTGTTACTGACTTTTGGGGGCCAGACT
GCTCTGAACTGTGGTGTGGAGCTGACCAAGGCCGGGGTGCTGGCTCGGTATGGGGTCCGG
GTCCTGGGCACAACAGTGGAGACCATTGAGCTGACCGAGGATCGACGGGCCTTTGCTGCC
AGAATGGCAGAGATCGGAGAGCATGTGGCCCCGAGCGAGGCAGGAAATTCTCTTGAACAG
GCCCAGGCAGCCGCTGAACGGCTGGGGTACCCTGTGCTAGTGCGTGCAGCCTTTGCCGTG
GGTGGCCTGGGCTCTGGCTTTGCCTCTAACAGGGAGGAGCTCTCTGCTCTCGTGGCCCCA
GCTTTTGCCCATACCAGCCAAGTGCTAGTAGACAAGTCTCTGAAGGGATGGAAGGAGATT
GAGTACGAGGTGGTGAGAGACGCCTATGGCAACTGTGTCACGGTGTGTAACATGGAGAAC
TTGGACCCACTGGGCATCCACACTGGTGAGTCCATAGTGGTGGCCCCTAGCCAGACACTG
AATGACAGGGAGTATCAGCTCCTGAGGCAGACAGCTATCAAGGTGACCCAGCACCTGGGA
ATTGTTGGGGAGTGCAATGTGCAGTATGCCTTGAACCCTGAGTCTGAGCAGTATTACATC
ATTGAAGTGAATGCCAGGCTCTCTCGCAGCTCTGCCCTGGCCAGTAAGGCCACAGGTTAT
CCACTGGCTTATGTGGCAGCCAAGCTAGCATTGGGCATCCCTTTGCCTGAGCTCAGGAAC
TCTGTGACAGGGGGTACAGCAGCCTTTGAACCCAGCGTGGATTATTGTGTGGTGAAGATT
CCTCGATGGGACCTTAGCAAGTTCCTGCGAGTCAGCACAAAGATTGGGAGCTGCATGAAG
AGCGTTGGTGAAGTCATGGGCATTGGGCGTTCATTTGAGGAGGCCTTCCAGAAGGCCCTG
CGCATGGTGGATGAGAACTGTGTGGGCTTTGATCACACAGTGAAACCAGTCAGCGATATG
GAGTTGGAGACTCCAACAGATAAGCGGATTTTTGTGGTGGCAGCTGCTTTGTGGGCTGGT
TATTCAGTGGACCGCCTGTATGAGCTCACACGCATCGACCGCTGGTTCCTGCACCGAATG
AAGCGTATCATCGCACATGCCCAGCTGCTAGAACAACACCGTGGACAGCCTTTGCCGCCA
GACCTGCTGCAACAGGCCAAGTGTCTTGGCTTCTCAGACAAACAGATTGCCCTTGCAGTT
CTGAGCACAGAGCTGGCTGTTCGCAAGCTGCGTCAGGAACTGGGGATCTGTCCAGCAGTG
AAACAGATTGACACAGTTGCAGCTGAGTGGCCAGCCCAGACAAATTACCTATACCTAACG
TATTGGGGCACCACCCATGACCTCACCTTTCGAACACCTCATGTCCTAGTCCTTGGCTCT
GGCGTCTACCGTATTGGCTCCAGTGTTGAGTTTGACTGGTGTGCTGTAGGCTGCATCCAG
CAGCTCCGAAAGATGGGATATAAGACCATCATGGTGAACTATAACCCAGAGACAGTCAGC
ACCGACTATGACATGTGTGATCGACTCTACTTTGATGAGATCTCTTTTGAGGTGGTGATG
GACATCTATGAGCTCGAGAACCCTGAAGGTGTGATCCTATCCATGGGTGGACAGCTGCCC
AACAACATGGCCATGGCGTTGCATCGGCAGCAGTGCCGGGTGCTGGGCACCTCCCCTGAA
GCCATTGACTCGGCTGAGAACCGTTTCAAGTTTTCCCGGCTCCTTGACACCATTGGTATC
AGCCAGCCTCAGTGGAGGGAGCTCAGTGACCTCGAGTCTGCTCGCCAATTCTGCCAGACC
GTGGGGTACCCCTGTGTGGTGCGCCCCTCCTATGTGCTGAGCGGTGCTGCTATGAATGTG
GCCTACGCGGATGGAGACCTGGAGCGCTTCCTGAGCAGCGCAGCAGCCGTCTCCAAAGAG
CATCCCGTGGTCATCTCCAAGTTCATCCAGGAGGCTAAGGAGATTGACGTGGATGCCGTG
GCCTCTGATGGTGTGGTGGCAGCCATCGCCATCTCTGAGCATGTGGAGAATGCAGGTGTG
CATTCAGGTGATGCGACGCTGGTGACCCCCCCACAAGATATCACTGCCAAAACCCTGGAG
CGGATCAAAGCCATTGTGCATGCTGTGGGCCAGGAGCTACAGGTCACAGGACCCTTCAAT
CTGCAGCTCATTGCCAAGGATGACCAGCTGAAAGTTATTGAATGCAACGTACGTGTCTCT
CGCTCCTTCCCCTTCGTTTCCAAGACACTGGGTGTGGACCTAGTAGCCTTGGCCACGCGG
GTCATCATGGGGGAAGAAGTGGAACCTGTGGGGCTAATGACTGGTTCTGGAGTCGTGGGA
GTAAAGGTGCCTCAGTTCTCCTTCTCCCGCTTGGCGGGTGCTGACGTGGTGTTGGGTGTG
GAAATGACCAGTACTGGGGAGGTGGCCGGCTTTGGGGAGAGCCGCTGTGAGGCATACCTC
AAGGCCATGCTAAGCACTGGCTTTAAGATCCCCAAGAAGAATATCCTGCTGACCATTGGC
AGCTATAAGAACAAAAGCGAGCTGCTCCCAACTGTGCGGCTACTGGAGAGCCTGGGCTAC
AGCCTCTATGCCAGTCTCGGCACAGCTGACTTCTACACTGAGCATGGCGTCAAGGTAACA
GCTGTGGACTGGCACTTTGAGGAGGCTGTGGATGGTGAGTGCCCACCACAGCGGAGCATC
CTGGAGCAGCTAGCTGAGAAAAACTTTGAGCTGGTGATTAACCTGTCAATGCGTGGAGCT
GGGGGCCGGCGTCTCTCCTCCTTTGTCACCAAGGGCTACCGCACCCGACGCTTGGCCGCT
GACTTCTCCGTGCCCCTAATCATCGATATCAAGTGCACCAAACTCTTTGTGGAGGCCCTA
GGCCAGATCGGGCCAGCCCCTCCTTTGAAGGTGCATGTTGACTGTATGACCTCCCAAAAG
CTTGTGCGACTGCCGGGATTGATTGATGTCCATGTGCACCTGCGGGAACCAGGTGGGACA
CATAAGGAGGACTTTGCTTCAGGCACAGCCGCTGCCCTGGCTGGGGGTATCACCATGGTG
TGTGCCATGCCTAATACCCGGCCCCCCATCATTGACGGCCCTGCTCTGGCCCTGGCCCAG
AAGCTGGCAGAGGCTGGCGCCCGGTGCGACTTTGCGCTATTCCTTGGGGCCTCGTCTGAA
AATGCAGGAACCTTGGGCACCGTGGCCGGGTCTGCAGCCGGGCTGAAGCTTTACCTCAAT
GAGACCTTCTCTGAGCTGCGGCTGGACAGCGTGGTCCAGTGGATGGAGCATTTCGAGACA
TGGCCCTCCCACCTCCCCATTGTGGCTCACGCAGAGCAGCAAACCGTGGCTGCTGTCCTC
ATGGTGGCTCAGCTCACTCAGCGCTCAGTGCACATATGTCACGTGGCACGGAAGGAGGAG
ATCCTGCTAATTAAAGCTGCAAAGGCACGGGGCTTGCCAGTGACCTGCGAGGTGGCTCCC
CACCACCTGTTCCTAAGCCATGATGACCTGGAGCGCCTGGGGCCTGGGAAGGGGGAGGTC
CGGCCTGAGCTTGGCTCCCGCCAGGATGTGGAAGCCCTGTGGGAGGACATGGCTGTCATC
GACTGCTTTGCCTCAGACCATGCTCCCCATACCTTGGAGGAGAAGTGTGGGTCCAGGCCC
CCACCTGGGTTCCCAGGGTTAGAGACCATGCTGCCACTACTCCTGACGGCTGTAAGCGAG
GGCCGGCTCAGCCTGGACGACCTGCTGCAGCGATTGCACCACAATCCTCGGCGCATCTTT
CACCTGCCCCCGCAGGAGGACACCTATGTGGAGGTGGATCTGGAGCATGAGTGGACAATT
CCCAGCCACATGCCCTTCTCCAAGGCCCACTGGACACCTTTTGAAGGGCAGAAAGTGAAG
GGCACCGTCCGCCGTGTGGTCCTGCGAGGGGAGGTTGCCTATATCGATGGGCAGGTTCTG
GTACCCCCGGGCTATGGACAGGATGTACGGAAGTGGCCACAGGGGGCTGTTCCTCAGCTC
CCACCCTCAGCCCCTGCCACTAGTGAGATGACCACGACACCTGAAAGACCCCGCCGTGGC
ATCCCAGGGCTTCCTGATGGCCGCTTCCATCTGCCGCCCCGAATCCATCGAGCCTCCGAC
CCAGGTTTGCCAGCTGAGGAGCCAAAGGAGAAGTCCTCTCGGAAGGTAGCCGAGCCAGAG
CTGATGGGAACCCCTGATGGCACCTGCTACCCTCCACCACCAGTACCGAGACAGGCATCT
CCCCAGAACCTGGGGACCCCTGGCTTGCTGCACCCCCAGACCTCACCCCTGCTGCACTCA
TTAGTGGGCCAACATATCCTGTCCGTCCAGCAGTTCACCAAGGATCAGATGTCTCACCTG
TTCAATGTGGCACACACACTGCGTATGATGGTGCAGAAGGAGCGGAGCCTCGACATCCTG
AAGGGGAAGGTCATGGCCTCCATGTTCTATGAAGTGAGCACACGGACCAGCAGCTCCTTT
GCAGCAGCCATGGCCCGGCTGGGAGGTGCTGTGCTCAGCTTCTCGGAAGCCACATCGTCC
GTCCAGAAGGGCGAATCCCTGGCTGACTCCGTGCAGACCATGAGCTGCTATGCCGACGTC
GTCGTGCTCCGGCACCCCCAGCCTGGAGCAGTGGAGCTGGCCGCCAAGCACTGCCGGAGG
CCAGTGATCAATGCTGGGGATGGGGTCGGAGAGCACCCCACCCAGGCCCTGCTGGACATC
TTCACCATCCGTGAGGAGCTGGGAACTGTCAATGGCATGACGATCACGATGGTGGGTGAC
CTGAAGCACGGACGCACAGTACATTCCCTGGCCTGCCTGCTCACCCAGTATCGTGTCAGC
CTGCGCTACGTGGCACCTCCCAGCCTGCGCATGCCACCCACTGTGCGGGCCTTCGTGGCC
TCCCGCGGCACCAAGCAGGAGGAATTCGAGAGCATTGAGGAGGCGCTGCCTGACACTGAT
GTGCTCTACATGACTCGAATCCAGAAGGAACGATTTGGCTCTACCCAGGAGTACGAAGCT
TGCTTTGGTCAGTTCATCCTCACTCCCCACATCATGACCCGGGCCAAGAAGAAGATGGTG
GTGATGCACCCGATGCCCCGTGTCAACGAGATAAGCGTGGAAGTGGACTCGGATCCCCGC
GCAGCCTACTTCCGCCAGGCTGAGAACGGCATGTACATCCGCATGGCTCTGTTAGCCACC
GTGCTGGGCCGTTTCTAG

# Metabolic_Enzyme_13_GenBank_ID_Gene:
D78586

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_13_Locus:
2p22-p21

# Metabolic_Enzyme_13_SNPs:
rs10193746; rs2304684; rs1141313; rs3739092; rs2078616; rs2014252; rs3769143; rs7593448; rs724310; rs13399758; rs6717980; rs724311; rs4665958; rs1275537; rs9679426; rs13395251; rs2043921; rs6749393; rs17005956; rs13424394; rs11685326; rs1275538; rs9309604; rs6756856; rs7589553; rs17005959; rs4665959; rs1561536; rs17005965; rs13384642; rs7557294; rs13394037; rs35133828; rs7573037; rs6747264; rs1141311; rs11559294; rs35391069; rs2289363; rs1056891; rs1141312; rs17855321; rs1275536; rs34716401; rs34760549; rs2289362; rs11682203; rs3739094; rs34370500; rs41288817; rs10172199; rs34961252; rs41288819; rs41288815; rs34977313; rs3739093; rs35508676; rs4603717; rs35275954; rs34729450; rs12612959; rs34346820; rs5830040; rs35324417; rs10636656; rs41288813; rs3214689; rs10172758; rs13430035; rs17005962; rs11361649; rs35233183; rs35736485; rs1044325; rs11126918; rs11126929; rs11126931; rs11608; rs11674947; rs11682913; rs11693660; rs11885879; rs11897090; rs11936; rs1275528; rs1275529; rs1275530; rs1275531; rs1275532; rs1275533; rs12986755; rs1561535; rs2083363; rs2580758; rs2580759; rs2735864; rs4617; rs4665960; rs6547496; rs7437; rs7600932; rs9653564; rs996650

# Metabolic_Enzyme_13_General_References:
8619816; 1979741

# Metabolic_Enzyme_13_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8533

# Macromolecular_Interacting_Partner_1_Name:
ASRGL1 protein

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
ASRGL1

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>ASRGL1 protein
MNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILREGGSAVDAVEGAVVALEDDPE
FNAGCGSVLNTNGEVEMDASIMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPHCFLTDQ
GAAQFAAAMGVPEIPGEKLVTERNKKRLEKEKHEKGAQKTDCQKNLGTVGAVALDCKGNV
AYATSTGGIVNKMVGRVGDSPCLGAGGYADNDIGAVSTTGHGESILKVNLARLTLFHIEQ
GKTVEEAADLSLGYMKSRVKGLGGLIVVSKTGDWVAKWTSTSMPWAAAKDGKLHFGIDPD
DTTITDLP

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
308

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
32055

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.17

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Function:  asparaginase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  glycoprotein metabolism
Process:  glycoprotein catabolism
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_1_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01112:Asparaginase_2

# Macromolecular_Interacting_Partner_1_Signals:
Not Available

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
62204511

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
Q567Q4_HUMAN (Q567Q4)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
ASRGL1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
ASRGL1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:16448

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>927 bp
ATGAATCCCATCGTAGTGGTCCACGGCGGCGGAGCCGGTCCCATCTCCAAGGATCGGAAG
GAGCGAGTGCACCAGGGCATGGTCAGAGCCGCCACCGTGGGCTACGGCATCCTCCGGGAG
GGCGGGAGCGCCGTGGATGCCGTAGAGGGAGCTGTCGTCGCCCTGGAAGACGATCCCGAG
TTCAACGCAGGTTGTGGGTCTGTCTTGAACACAAATGGTGAGGTTGAAATGGATGCTAGT
ATCATGGATGGAAAAGACCTGTCTGCAGGAGCAGTGTCCGCAGTCCAGTGTATAGCAAAT
CCCATTAAACTTGCTCGGCTTGTCATGGAAAAGACACCTCATTGCTTTCTGACTGACCAA
GGCGCAGCGCAGTTTGCAGCAGCTATGGGGGTTCCAGAGATTCCTGGAGAAAAACTGGTG
ACAGAGAGAAACAAAAAGCGCCTGGAAAAAGAGAAGCATGAAAAAGGTGCTCAGAAAACA
GATTGTCAAAAAAACTTGGGAACCGTGGGTGCTGTTGCCTTGGACTGCAAAGGGAATGTA
GCCTACGCAACCTCCACAGGCGGTATCGTTAATAAAATGGTCGGCCGCGTTGGGGACTCA
CCGTGTCTAGGAGCTGGAGGTTATGCCGACAATGACATCGGAGCCGTCTCAACCACAGGG
CATGGGGAAAGCATCCTGAAGGTGAACCTGGCTAGACTCACCCTGTTCCACATAGAACAA
GGAAAGACGGTAGAAGAGGCTGCGGACCTATCGTTGGGTTATATGAAGTCAAGGGTTAAA
GGTTTAGGTGGCCTCATCGTGGTTAGCAAAACAGGAGACTGGGTGGCAAAGTGGACCTCC
ACCTCCATGCCCTGGGCAGCCGCCAAGGACGGCAAGCTGCACTTCGGAATTGATCCTGAC
GATACTACTATCACCGACCTTCCCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
BC093070

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11q12.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs3741244; rs3741245; rs4281490; rs2277281; rs2513749; rs3216739; rs15810; rs11606114; rs2302360; rs2958531; rs4432028; rs7116792; rs11822408; rs12292642; rs3018622; rs7941556; rs2513052; rs2513051; rs2958532; rs10897261; rs11820258; rs12292586; rs10897267; rs951677; rs10792346; rs10897266; rs10792351; rs11605965; rs1881535; rs11231042; rs7119235; rs7109277; rs11608211; rs11231067; rs11821255; rs10897260; rs12287823; rs2302359; rs7115632; rs2463836; rs2513738; rs10792350; rs11231053; rs12419894; rs2513077; rs2513737; rs7105219; rs11231070; rs2513054; rs7111902; rs11231069; rs7127401; rs4340061; rs2302361; rs7123323; rs11231051; rs17157218; rs11231046; rs10897259; rs7113399; rs10792347; rs11231062; rs12285902; rs7103755; rs11231045; rs11604863; rs9667211; rs11231059; rs10897264; rs11604275; rs11231068; rs10437726; rs5017020; rs7105622; rs10750974; rs12274086; rs4536220; rs2513053; rs7943362; rs11231044; rs7118756; rs11821315; rs11820150; rs11231065; rs10897265; rs11231047; rs11820997; rs7110781; rs7481995; rs7105843; rs11826669; rs10792345; rs12282077; rs11231061; rs11231055; rs4502002; rs12294413; rs11231071; rs7928732; rs2246920; rs2463822; rs2246925; rs4465372; rs2513076; rs34180063; rs5792256; rs36101350; rs17845648; rs10524135; rs28678254; rs34743439; rs34950346; rs34840364; rs35931241; rs11231056; rs11600883; rs34776557; rs34150528; rs7104831; rs12807451; rs34472338; rs7482885; rs12802498; rs34522226; rs34694043; rs34027697; rs12574213; rs11231039; rs7483087; rs35105438; rs10656254; rs11821712; rs11603424; rs35737806; rs34237835; rs11231043; rs34891208; rs36137866; rs3180047; rs4963504; rs35096038; rs12274759; rs11827263; rs11231050; rs12420033; rs35114658; rs35136967; rs10656253; rs12224129; rs2463820; rs12799816; rs34547539; rs9667654; rs3180879; rs3018619; rs11231063; rs34834191; rs12573986; rs35798082; rs12574677; rs34191855; rs11330625; rs3832779; rs11231049; rs12802501; rs7932577; rs12787924; rs7124935; rs3180880; rs3180646; rs12804628; rs2463821; rs34853836; rs3206772; rs12802660; rs35068655; rs12274607; rs2463837; rs28583008; rs5792255; rs34574964; rs11231041; rs34446979; rs10656816; rs36033542; rs35551368; rs3832778; rs12801810; rs11600424; rs7932568; rs7109686; rs12794304; rs35345092; rs34956831; rs11231048; rs34075806; rs35333346; rs35205241; rs35341808; rs11231040; rs11231060; rs35140033; rs7947190; rs35684001; rs35296627; rs35495143; rs28641974; rs12807615; rs35854084; rs34114318; rs12282415; rs11231066; rs35499940; rs7125465; rs10599499; rs35311476; rs34703429; rs10618086; rs4519096; rs1043789; rs10501332; rs11231058; rs11231073; rs11231075; rs11231076; rs11231079; rs11605111; rs11823982; rs12226795; rs12274789; rs17157227; rs2513071; rs2513075; rs2513747; rs2958530; rs3018620; rs3018621; rs34037877; rs34533893; rs35961711; rs4334021; rs4963296; rs4963499; rs4963505; rs7113294; rs7113359; rs7118241; rs7118835; rs7119797; rs7127368; rs7931774; rs7941992; rs948580

# Macromolecular_Interacting_Partner_1_General_References:
12477932

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8631

# Macromolecular_Interacting_Partner_2_Name:
Excitatory amino acid transporter 3

# Macromolecular_Interacting_Partner_2_Synonyms:
Solute carrier family 1 member 1; Sodium-dependent glutamate/aspartate transporter 3; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter

# Macromolecular_Interacting_Partner_2_Gene_Name:
SLC1A1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Excitatory amino acid transporter 3
MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILM
RMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGV
TQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMT
EESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFF
NALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVI
LPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLP
VGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMV
IVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVN
IVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
524

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
57101

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.36

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  transporter activity
Function:  organic acid transporter activity
Function:  carboxylic acid transporter activity
Function:  dicarboxylic acid transporter activity
Function:  sodium:dicarboxylate symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  organic acid transport
Process:  carboxylic acid transport
Process:  dicarboxylic acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_2_Specific_Function:
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00375:SDF

# Macromolecular_Interacting_Partner_2_Signals:
1-31

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
19-38
62-82
94-114
210-229
254-273
290-309
316-335
362-381
392-411
420-439

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
507898

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
EAA3_HUMAN (P43005)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
SLC1A1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
SLC1A1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:10939

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1575 bp
ATGGGGAAACCGGCGAGGAAAGGATGCGAGTGGAAGCGCTTCCTGAAGAATAACTGGGTG
TTGCTGTCCACCGTGGCCGCGGTGGTGCTAGGCATTACCACAGGAGTCTTGGTTCGAGAA
CACAGCAACCTCTCAACTCTAGAGAAATTCTACTTTGCTTTTCCTGGAGAAATTCTAATG
CGGATGCTGAAACTCATCATTTTGCCATTAATTATATCCAGCATGATTACAGGTGTTGCT
GCACTGGATTCCAACGTATCCGGAAAAATTGGTCTGCGCGTCGTCGTGTATTATTTCTGT
ACCACTCTCATTGCTGTTATTCTAGGTATTGTGCTGGTGGTGAGCATCAAGCCTGGTGTC
ACCCAGAAAGTGGGTGAAATTGCGAGGACAGGCAGCACCCCTGAAGTCAGTACGGTGGAT
GCCATGTTAGATCTCATCAGGAATATGTTCCCTGAGAATCTTGTCCAGGCCTGTTTTCAG
CAGTACAAAACTAAGCGTGAAGAAGTGAAGCCTCCCAGCGATCCAGAGATGAACATGACA
GAAGAGTCCTTCACAGCTGTCATGACAACTGCAATTTCCAAGAACAAAACAAAGGAATAC
AAAATTGTTGGCATGTATTCAGATGGCATAAACGTCCTGGGCTTGATTGTCTTTTGCCTT
GTCTTTGGACTTGTCATTGGAAAAATGGGAGAAAAGGGACAAATTCTGGTGGATTTCTTC
AATGCTTTGAGTGATGCAACCATGAAAATCGTTCAGATCATCATGTGTTATATGCCACTA
GGTATTTTGTTCCTGATTGCTGGGAAGATCATAGAAGTTGAAGACTGGGAAATATTCGCA
AAGCTGGGCCTTTACATGGCCACAGTCCTGACTGGGCTTGCAATCCACTCCATTGTAATT
CTCCCGCTGATATATTTCATAGTCGTACGAAAGAACCCTTTCCGATTTGCCATGGGAATG
GCCCAGGCTCTCCTGACAGCTCTCATGATCTCTTCCAGTTCAGCAACACTGCCTGTCACC
TTCCGCTGTGCTGAAGAAAATAACCAGGTGGACAAGAGGATCACTCGATTCGTGTTACCC
GTTGGTGCAACAATCAACATGGATGGGACTGCGCTCTATGAAGCAGTGGCAGCGGTGTTT
ATTGCACAGTTGAATGACCTGGACTTGGGCATTGGGCAGATCATCACCATCAGTATCACG
GCCACATCTGCCAGCATCGGAGCTGCTGGCGTGCCCCAGGCTGGCCTGGTGACCATGGTG
ATTGTGCTGAGTGCCGTGGGCCTGCCCGCCGAGGATGTCACCCTGATCATTGCTGTCGAC
TGGCTCCTGGACCGGTTCAGGACCATGGTCAACGTCCTTGGTGATGCTTTTGGGACGGGC
ATTGTGGAAAAGCTCTCCAAGAAGGAGCTGGAGCAGATGGATGTTTCATCTGAAGTCAAC
ATTGTGAATCCTTTTGCCTTGGAATCCACAATCCTTGACAACGAAGACTCAGACACCAAG
AAGTCTTATGTCAATGGAGGCTTTGCAGTAGACAAGTCTGACACCATCTCATTCACCCAG
ACCTCACAGTTCTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
U08989

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_2_Locus:
9p24

# Macromolecular_Interacting_Partner_2_SNPs:
rs16921449; rs2026828; rs1888279; rs2039291; rs1980943; rs2039216; rs2094806; rs10758631; rs7046262; rs7029281; rs928209; rs10758628; rs7848533; rs10758624; rs10739065; rs7025968; rs7851538; rs2039290; rs4742003; rs10739064; rs7023050; rs2026829; rs10118909; rs7033181; rs6476876; rs7021569; rs10814995; rs10758629; rs9918970; rs7044130; rs10814998; rs6476877; rs6476875; rs7862687; rs10815015; rs10491732; rs10814997; rs7022369; rs10115600; rs7032326; rs4742005; rs10815004; rs6476871; rs10974588; rs17755777; rs4742004; rs10733515; rs7860087; rs10117861; rs10974615; rs7030825; rs7037863; rs6476873; rs10974592; rs7045401; rs2150195; rs10491731; rs6476874; rs10815002; rs10119456; rs17812372; rs913991; rs951458; rs7021409; rs10116014; rs7041093; rs972519; rs10758632; rs10815013; rs10815016; rs16921385; rs7864309; rs10814991; rs10739062; rs10758623; rs7867651; rs7849913; rs6476872; rs17812250; rs7864081; rs10974587; rs10974616; rs7024664; rs17812268; rs12342908; rs10815019; rs7038739; rs12004546; rs12003904; rs16921457; rs12004065; rs10815018; rs10974610; rs7860715; rs12338459; rs12002726; rs16921367; rs17755625; rs10974594; rs12380549; rs10739061; rs10815011; rs10974577; rs10974581; rs10974600; rs7852072; rs10814994; rs10118904; rs10974590; rs10815010; rs10815017; rs10974597; rs10119479; rs7864220; rs1330688; rs17811619; rs17811535; rs7857946; rs10974601; rs10815009; rs10974582; rs17755904; rs17811505; rs13289148; rs10814993; rs10815014; rs17755472; rs10815003; rs17812396; rs10974612; rs7030226; rs7848305; rs9774826; rs10974586; rs10974591; rs7873961; rs10974614; rs9777096; rs10815006; rs17756150; rs7468917; rs7029501; rs10758626; rs4641119; rs10974611; rs12003869; rs17755789; rs10815008; rs10814992; rs10739063; rs12351945; rs10974613; rs10974606; rs10815005; rs12341219; rs7036458; rs12351328; rs10974580; rs17756556; rs7046808; rs10120326; rs7027993; rs17812232; rs4008488; rs10974584; rs10974607; rs1330686; rs10815012; rs17755168; rs10815007; rs7850152; rs7031998; rs1360329; rs7043415; rs1537035; rs2017074; rs10814990; rs4740789; rs1807276; rs2381122; rs884931; rs12000219; rs7026816; rs35883411; rs10974605; rs35964381; rs35461755; rs35169624; rs34455753; rs34089295; rs35074500; rs34997218; rs35752798; rs12005504; rs34994137; rs36057961; rs34866467; rs1888280; rs34014603; rs34939038; rs34489534; rs35698960; rs35190872; rs12006310; rs12001534; rs34976367; rs36164361; rs7019270; rs35875422; rs5896082; rs12352574; rs10974585; rs35158764; rs34256260; rs35815316; rs3038189; rs10974599; rs34600342; rs13289187; rs10974604; rs10974593; rs7866742; rs7033497; rs10974609; rs11535414; rs34665485; rs34199207; rs7852263; rs35714906; rs10974598; rs35337308; rs7470929; rs10974589; rs34928579; rs2890588; rs36097515; rs34195319; rs12005500; rs5896081; rs10114781; rs12350574; rs4517184; rs35672344; rs7038104; rs1330689; rs34899758; rs36157852; rs34258078; rs34271544; rs12353010; rs36051748; rs34630480; rs10974595; rs10974608; rs35001777; rs10974579; rs34147711; rs10758630; rs5896079; rs28852219; rs10116863; rs35897785; rs11521467; rs7048761; rs10974617; rs11521469; rs34428793; rs5896080; rs4373569; rs6150901; rs12341097; rs10974596; rs7856981; rs34982876; rs34881451; rs34631013; rs12351985; rs34559140; rs34337455; rs34738080; rs10974575; rs11521468; rs7029194; rs10974578; rs34610062; rs10974574; rs5896078; rs10117931; rs10121074; rs10491733; rs10491734; rs10491735; rs1051818; rs1051825; rs1051830; rs1051831; rs1051835; rs10739066; rs1078539; rs10814987; rs10814988; rs10815020; rs10815021; rs10974568; rs10974573; rs10974619; rs10974620; rs10974622; rs10974623; rs10974624; rs10974625; rs10974628; rs10974629; rs10974632; rs10974634; rs10974635; rs10974636; rs11788512; rs11791930; rs11792309; rs11795172; rs11999543; rs12001262; rs12002441; rs12004839; rs12005132; rs12336560; rs12337810; rs12353525; rs12378107; rs12379402; rs12551465; rs12553697; rs12682807; rs13285395; rs1471786; rs159914; rs159916; rs16921510; rs17756747; rs17756784; rs17814324; rs184204; rs188537; rs190978; rs2072657; rs2150192; rs2183472; rs2228622; rs301429; rs301430; rs301431; rs301432; rs301433; rs301434; rs301435; rs301436; rs301437; rs301439; rs301440; rs301441; rs301443; rs301444; rs301445; rs301446; rs301979; rs3056; rs3087879; rs34342853; rs34345944; rs34623313; rs35045656; rs3780411; rs3780412; rs3780413; rs3780414; rs3780415; rs4376537; rs4376542; rs4740788; rs4740790; rs4742006; rs4742007; rs4742008; rs4742009; rs4742010; rs4742011; rs6476878; rs6476879; rs7022772; rs7042333; rs7045876; rs7856675; rs7858215; rs7858819; rs7858877; rs7864496; rs7868565; rs7871243; rs7871691; rs7872075; rs9407286; rs9886720; rs9886723; rs9886808; rs9886847

# Macromolecular_Interacting_Partner_2_General_References:
7859077; 7914198; 7521911

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8680

# Macromolecular_Interacting_Partner_3_Name:
Excitatory amino acid transporter 1

# Macromolecular_Interacting_Partner_3_Synonyms:
Solute carrier family 1 member 3; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC1A3

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Excitatory amino acid transporter 1
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIV
GTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMG
MRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPP
NLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNG
VNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGK
IVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITAL
GTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFE
LNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRT
TTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSET
KM

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
542

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
59573

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
8.69

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
 Function:  transporter activity
Function:  organic acid transporter activity
Function:  carboxylic acid transporter activity
Function:  dicarboxylic acid transporter activity
Function:  sodium:dicarboxylate symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  organic acid transport
Process:  carboxylic acid transport
Process:  dicarboxylic acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_3_Specific_Function:
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00375:SDF

# Macromolecular_Interacting_Partner_3_Signals:
Not Available

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
48-68
91-111
123-145
238-260
281-302
319-340

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
EAA1_HUMAN (P43003)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC1A3

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC1A3

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:10941

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
L19158

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_3_Locus:
5p13

# Macromolecular_Interacting_Partner_3_SNPs:
rs2032892; rs890922; rs2269272; rs1049524; rs1049522; rs4591778; rs7724801; rs13436644; rs13154397; rs2229894; rs6879542; rs10078147; rs1864214; rs2303716; rs1366638; rs2301065; rs1549627; rs1645660; rs1423677; rs2301068; rs891189; rs930072; rs1971720; rs1645651; rs2113098; rs1366632; rs2301067; rs366597; rs2301066; rs4869685; rs10070340; rs3776567; rs7712125; rs3903407; rs378427; rs7704118; rs372171; rs3776581; rs1428974; rs1864213; rs4869684; rs3776568; rs442867; rs7721893; rs7734056; rs7729402; rs2432213; rs2301064; rs7728680; rs4869676; rs753813; rs4869681; rs1001571; rs3776572; rs10941308; rs9292637; rs1030239; rs3733810; rs3776564; rs2364935; rs10941311; rs6451304; rs448281; rs3776565; rs3776586; rs3756468; rs16903252; rs3776573; rs10491375; rs3753180; rs17290929; rs10941306; rs12516475; rs11957945; rs12659371; rs17368211; rs17290638; rs3776577; rs10941309; rs3776583; rs3776566; rs13168598; rs3776576; rs371511; rs745429; rs7730373; rs13166160; rs1423679; rs1544795; rs3822469; rs6451303; rs4869683; rs1645658; rs4869486; rs3776578; rs1428968; rs7728030; rs2269271; rs3776587; rs3776569; rs10512660; rs3776579; rs1428967; rs2033267; rs13159713; rs2052885; rs4869677; rs10491374; rs16903198; rs3776585; rs4869682; rs4869680; rs11954014; rs9292638; rs16903247; rs10512661; rs10056001; rs16903222; rs12188287; rs3776570; rs16903237; rs10473034; rs369708; rs9283745; rs6892871; rs4869686; rs6881822; rs426040; rs1862638; rs2115523; rs10941312; rs11750072; rs1622132; rs2161608; rs3776563; rs16903256; rs9790917; rs3733811; rs11748249; rs10941313; rs16903262; rs12054904; rs13173144; rs10941310; rs13362437; rs2364932; rs3822468; rs2115522; rs7730537; rs3051481; rs379979; rs16903263; rs6868250; rs6896530; rs12518875; rs962686; rs745428; rs10057629; rs13179272; rs1423678; rs2033224; rs7729389; rs12518871; rs1423680; rs3756467; rs432268; rs3733812; rs10062853; rs3776571; rs10080178; rs2303715; rs1428975; rs12518891; rs16903205; rs10941307; rs4020423; rs2562581; rs2731886; rs1428973; rs2562582; rs3814068; rs9292636; rs10042564; rs3814067; rs11949360; rs11543905; rs34809305; rs17853737; rs35095566; rs35302142; rs11542585; rs2269273; rs1049520; rs6860949; rs34002322; rs1803715; rs6886600; rs5867331; rs10428531; rs11379538; rs35152088; rs3836803; rs6861465; rs17511061; rs10547870; rs35501123; rs35449337; rs3842036; rs1864212; rs35018051; rs7716057; rs11284735; rs35688678; rs11336594; rs10580203; rs35286117; rs10710837; rs34963761; rs5867333; rs11407453; rs13171136; rs6891580; rs10712185; rs34105781; rs34118681; rs35982078; rs3216728; rs34842454; rs7737476; rs7721587; rs35974769; rs35128248; rs10428554; rs13153345; rs13166338; rs35415040; rs4421131; rs5867334; rs1651849; rs34593765; rs17585568; rs36073020; rs6866248; rs35680188; rs1645657; rs34874003; rs35935808; rs34107449; rs581672; rs3216691; rs34789636; rs13166348; rs13361257; rs11321730; rs35658500; rs10069687; rs35685899; rs10038104; rs34594159; rs34495762; rs16903249; rs34862389; rs13170531; rs7726798; rs6872594; rs10079671; rs11409804; rs34710652; rs33984004; rs17368246; rs35558789; rs11285678; rs34433201; rs1651843; rs35937623; rs3776580; rs34686767; rs35350307; rs13185283; rs35191716; rs35578203; rs5867335; rs13178960; rs11361098; rs13166336; rs13164080; rs33955795; rs10637092; rs13166333; rs35394001; rs11284736; rs7710493; rs35507054; rs3833999; rs35654981; rs11286949; rs7732356; rs7703416; rs11292001; rs35209056; rs28458324; rs13355695; rs10473035; rs6862950; rs13170953; rs7713760; rs35761187; rs391031; rs11379742; rs5867332; rs7703852; rs34884619; rs34676530; rs13174138; rs12659296; rs1645659; rs12188037; rs34050141; rs35788656; rs10223091; rs41491650; rs11379803; rs3836802; rs35501352; rs8180423; rs28488541; rs34520204; rs6861244; rs13184339; rs34118423; rs381788; rs34955617; rs3051477; rs13184332; rs1428966; rs28447084; rs36124990; rs16903193; rs28491541; rs1122900; rs11741316; rs11743024; rs11743817; rs11953157; rs12189401; rs12651999; rs12654391; rs12654484; rs13155110; rs1366637; rs1529461; rs16903174; rs16903188; rs1995279; rs2562571; rs2562573; rs2562574; rs2562575; rs2562576; rs2562577; rs2562578; rs2562579; rs2562580; rs2731877; rs2731878; rs2731879; rs2731880; rs2731881; rs2731882; rs2731883; rs2731884; rs4443439; rs4527636; rs4532385; rs4869487; rs4869675; rs4869687; rs6451302; rs6863386; rs6887423; rs6896326; rs7703253; rs7704100; rs7730144; rs957904; rs957905

# Macromolecular_Interacting_Partner_3_General_References:
7521911; 8123008; 8647279

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8693

# Macromolecular_Interacting_Partner_4_Name:
Calcium-binding mitochondrial carrier protein Aralar1

# Macromolecular_Interacting_Partner_4_Synonyms:
Mitochondrial aspartate glutamate carrier 1; Solute carrier family 25 member 12

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC25A12

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Calciumbinding mitochondrial carrier protein Aralar1
MAVKVQTTKRGDPHELRNIFLQYASTEVDGERYMTPEDFVQRYLGLYNDPNSNPKIVQLL
AGVADQTKDGLISYQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEVTFENVKEIFGQTII
HHHIPFNWDCEFIRLHFGHNRKKHLNYTEFTQFLQELQLEHARQAFALKDKSKSGMISGL
DFSDIMVTIRSHMLTPFVEENLVSAAGGSISHQVSFSYFNAFNSLLNNMELVRKIYSTLA
GTRKDVEVTKEEFAQSAIRYGQVTPLEIDILYQLADLYNASGRLTLADIERIAPLAEGAL
PYNLAELQRQQSPGLGRPIWLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGS
GSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRR
DGSVPLPAEVLAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLRDLGIFGL
YKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNLLAAGAMAGVPAASLVTPAD
VIKTRLQVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLAHYEV
LQRWFYIDFGGLKPAGSEPTPKSRIADLPPANPDHIGGYRLATATFAGIENKFGLYLPKF
KSPSVAVVQPKAAVAATQ

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
678

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
74757

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.56

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
 Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
Function:  transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  organelle membrane
Component:  organelle inner membrane
Component:  mitochondrial inner membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Calcium-dependent mitochondrial aspartate and glutamate carrier. May have a function in the urea cycle

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00036:efhand
PF00153:Mito_carr

# Macromolecular_Interacting_Partner_4_Signals:
Not Available

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
330-347
391-410
434-447
483-502
522-539
579-598

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
3559910

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
CMC1_HUMAN (O75746)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC25A12

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC25A12

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:10982

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Mitochondrion; mitochondrial inner membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>2037 bp
ATGGCGGTCAAGGTGCAGACAACTAAGCGAGGGGATCCTCATGAGTTAAGAAACATATTT
CTACAGTATGCCAGTACTGAGGTTGATGGAGAGCGTTACATGACCCCAGAAGACTTTGTT
CAGCGCTATCTTGGACTGTATAATGATCCAAATAGTAACCCAAAGATCGTGCAGCTCTTG
GCAGGAGTAGCTGATCAAACCAAGGATGGGTTGATCTCCTATCAAGAGTTTTTGGCATTT
GAATCTGTTTTATGTGCTCCAGATTCCATGTTCATAGTGGCTTTCCAGTTGTTTGACAAG
AGTGGAAATGGAGAGGTGACATTTGAAAATGTCAAAGAAATTTTTGGACAGACTATTATT
CATCATCATATCCCTTTTAACTGGGATTGTGAATTTATCCGACTGCATTTTGGGCATAAC
CGGAAGAAGCATCTTAACTACACAGAATTCACGCAGTTTCTCCAGGAGCTGCAATTGGAA
CATGCAAGACAAGCCTTTGCACTCAAAGACAAAAGCAAAAGTGGCATGATTTCTGGTCTG
GATTTCAGTGACATCATGGTTACCATTAGATCTCACATGCTTACTCCTTTTGTGGAGGAG
AACTTAGTTTCAGCAGCTGGAGGAAGTATCTCACACCAGGTTAGCTTCTCCTACTTCAAT
GCATTTAACTCGTTACTGAATAACATGGAGCTTGTTCGTAAGATATATAGCACTCTAGCT
GGCACAAGGAAAGATGTTGAAGTCACAAAGGAGGAATTTGCCCAGAGTGCCATACGCTAT
GGACAAGTCACACCACTAGAAATTGATATTCTATATCAGCTTGCAGACTTATATAATGCT
TCAGGGCGCTTGACTTTGGCAGATATTGAGAGAATAGCCCCATTGGCTGAGGGGGCCTTA
CCTTACAACCTGGCAGAACTTCAGAGACAGCAGTCTCCTGGGTTAGGCAGGCCTATCTGG
CTCCAGATTGCCGAGTCTGCTTACAGATTCACTCTGGGCTCAGTTGCTGGAGCTGTGGGA
GCCACTGCAGTGTATCCTATAGATCTGGTGAAGACCCGAATGCAAAACCAGCGTGGCTCT
GGCTCTGTTGTTGGGGAGCTAATGTACAAAAACAGCTTTGACTGTTTTAAGAAAGTCTTG
CGTTATGAGGGCTTCTTTGGACTCTACAGGGGTCTGATACCACAACTTATAGGGGTTGCT
CCAGAAAAGGCCATTAAACTGACTGTTAATGATTTTGTTCGGGACAAATTTACCAGAAGA
GATGGCTCTGTTCCACTTCCAGCAGAAGTTCTTGCTGGAGGCTGTGCTGGAGGCTCTCAG
GTCATTTTTACCAACCCATTGGAGATAGTGAAGATTCGTCTGCAAGTAGCTGGAGAGATC
ACCACGGGACCCAGAGTCAGCGCCCTGAATGTGCTCCGGGACTTGGGAATTTTTGGTCTG
TATAAGGGTGCCAAAGCGTGTTTCCTCCGAGACATTCCCTTCTCTGCAATCTATTTTCCT
GTTTATGCTCATTGCAAACTACTTCTGGCTGATGAAAATGGACACGTGGGAGGTTTAAAT
CTTCTTGCAGCTGGAGCCATGGCAGGTGTCCCAGCTGCATCTCTGGTGACCCCTGCTGAT
GTCATCAAGACAAGACTGCAGGTGGCTGCCCGCGCTGGCCAGACGACATACAGTGGTGTC
ATCGACTGTTTCAGGAAGATTCTCCGGGAAGAAGGGCCCTCAGCATTTTGGAAAGGGACT
GCAGCTCGAGTGTTTCGATCCTCTCCCCAGTTTGGTGTTACCTTGGCTCATTATGAAGTT
CTCCAGCGGTGGTTTTACATTGATTTTGGAGGCCTCAAACCCGCTGGTTCAGAACCAACA
CCTAAGTCACGCATTGCAGACCTTCCTCCTGCCAACCCTGATCACATCGGTGGATACAGA
CTCGCCACAGCCACGTTTGCAGGCATCGAAAACAAATTTGGCCTTTATCTCCCGAAATTT
AAGTCTCCTAGTGTTGCTGTGGTTCAGCCAAAGGCAGCAGTGGCAGCCACTCAGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
Y14494

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_4_Locus:
2q24

# Macromolecular_Interacting_Partner_4_SNPs:
rs35565687; rs1878583; rs11757; rs13035825; rs2292813; rs949548; rs908670; rs2271758; rs6433313; rs7608403; rs6725388; rs4668414; rs10930497; rs3770453; rs6745143; rs12692974; rs3770457; rs2056202; rs3770445; rs925881; rs12692973; rs12692978; rs7586207; rs3821096; rs3770451; rs7573003; rs6433315; rs3770455; rs3770452; rs12692976; rs970948; rs6754817; rs908671; rs2357064; rs10167419; rs3736499; rs3821093; rs12692977; rs3770458; rs1010533; rs3770449; rs3770448; rs6433317; rs12614709; rs13021138; rs3821095; rs12617655; rs1400816; rs7580232; rs11675404; rs3770459; rs3770444; rs3765166; rs6758704; rs6433314; rs2357206; rs6724337; rs12620126; rs6760680; rs12619067; rs3770443; rs6759575; rs6716901; rs12692979; rs3821092; rs17581284; rs2176466; rs7588025; rs6711813; rs1810338; rs1554259; rs17581439; rs1996424; rs1474074; rs11683867; rs2884123; rs17499593; rs11903123; rs7604821; rs6708365; rs3836018; rs11695029; rs3821094; rs3841888; rs10196521; rs3765167; rs6433316; rs1973706; rs17499864; rs1996425; rs9636293; rs1022358; rs7604933; rs2138872; rs17848721; rs7559830; rs12617265; rs3770450; rs10930495; rs7355523; rs17581347; rs13016580; rs17581361; rs11681772; rs11691344; rs6727459; rs925880; rs1973707; rs2276663; rs12990355; rs10803864; rs10930496; rs1105264; rs3770447; rs4668415; rs13018433; rs17615262; rs1105265; rs10191399; rs12619137; rs3836022; rs12622895; rs10497374; rs17499544; rs16859910; rs7355594; rs16859913; rs1059299; rs35881803; rs34360900; rs34495966; rs11383727; rs34728188; rs13410354; rs11319504; rs35917877; rs35734959; rs10183489; rs13384761; rs13386054; rs2138873; rs3058854; rs35240724; rs35085643; rs1106128; rs35884930; rs35854151; rs2138870; rs11467625; rs36075483; rs9808259; rs7603693; rs34985441; rs1810337; rs6707769; rs11458998; rs35883925; rs2176465; rs35571106; rs4668417; rs34070184; rs10545880; rs5836358; rs35252270; rs34370641; rs28796399; rs35493684; rs33956024; rs3836020; rs34957062; rs13419006; rs7603734; rs7593547; rs4668413; rs35488959; rs5836354; rs7355682; rs35898293; rs12105803; rs10700205; rs5836352; rs34551773; rs5836348; rs35136672; rs2176463; rs34056004; rs35208355; rs34221876; rs2176464; rs11442059; rs7608126; rs35628650; rs9749665; rs3059619; rs4027460; rs34797144; rs35087603; rs3836023; rs12470947; rs35540110; rs5836350; rs34431704; rs34541867; rs11397761; rs5836359; rs5836356; rs3951140; rs4027498; rs34924955; rs35592338; rs36000280; rs3770454; rs35030474; rs35465172; rs34870718; rs4668416; rs10174500; rs10557724; rs34563971; rs12617775; rs3765165; rs34663530; rs11450885; rs3058855; rs35712142; rs3836021; rs5836355; rs6709299; rs34184326; rs34327434; rs17848724; rs1829280; rs10179020; rs6736159; rs35087387; rs5836360; rs5836353; rs28748268; rs28379476; rs13022113; rs35336101; rs11392499; rs35057271; rs5836351; rs3836024; rs28810752; rs34833030; rs33946025; rs11344201; rs13017585; rs35978684; rs6726991; rs34388286; rs11428637; rs12991441; rs5836349; rs5836357; rs35801245; rs13021571; rs7592272; rs34467890; rs34203221; rs36102410; rs7584258; rs34295600; rs35860484; rs2138871; rs13025660; rs35160953; rs3836019; rs35288816; rs34962243; rs34276775; rs34494239; rs34108287; rs34139128; rs12053046; rs35160434; rs10646758; rs949648; rs13429367; rs34492103; rs10174525; rs1113390; rs6705200; rs6753859; rs7421773

# Macromolecular_Interacting_Partner_4_General_References:
9722566; 10369257; 11566871

# Macromolecular_Interacting_Partner_4_References:
Not Available

# Macromolecular_Interacting_Partner_5_ID:
8698

# Macromolecular_Interacting_Partner_5_Name:
Excitatory amino acid transporter 2

# Macromolecular_Interacting_Partner_5_Synonyms:
Solute carrier family 1 member 2; Sodium-dependent glutamate/aspartate transporter 2; Glutamate/aspartate transporter II

# Macromolecular_Interacting_Partner_5_Gene_Name:
SLC1A2

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Excitatory amino acid transporter 2
MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVC
GGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRA
MVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENL
VQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGM
NVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKI
IAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALG
TASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVL
DGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTS
VNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYA
AHNSVIVDECKVTLAANGKSADCSVEEEPWKREK

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
574

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
62105

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.51

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
 Function:  transporter activity
Function:  organic acid transporter activity
Function:  carboxylic acid transporter activity
Function:  dicarboxylic acid transporter activity
Function:  sodium:dicarboxylate symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  organic acid transport
Process:  carboxylic acid transport
Process:  dicarboxylic acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_5_Specific_Function:
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00375:SDF

# Macromolecular_Interacting_Partner_5_Signals:
Not Available

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
45-64
88-108
121-142
240-259
280-301
317-339
406-430
437-459

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
487341

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
EAA2_HUMAN (P43004)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
SLC1A2

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
SLC1A2

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:10940

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1725 bp
ATGGCATCTACGGAAGGTGCCAACAATATGCCCAAGCAGGTGGAAGTGCGAATGCCAGAC
AGTCATCTTGGCTCAGAGGAACCCAAGCACCGGCACCTGGGCCTGCGCCTGTGTGACAAG
CTGGGGAAGAATCTGCTGCTCACCCTGACGGTGTTTGGTGTCATCCTGGGAGCAGTGTGT
GGAGGGCTTCTTCGCTTGGCATCTCCCATCCACCCTGATGTGGTTATGTTAATAGCCTTC
CCAGGGGATATACTCATGAGGATGCTAAAAATGCTCATTCTCCCTCTAATCATCTCCAGC
TTAATCACAGGGTTGTCAGGCCTGGATGCTAAGGCTAGTGGCCGCTTGGGCACGAGAGCC
ATGGTGTATTACATGTCCACGACCATCATTGCTGCAGTACTGGGGGTCATTCTGGTCTTG
GCTATCCATCCAGGCAATCCCAAGCTCAAGAAGCAGCTGGGGCCTGGGAAGAAGAATGAT
GAAGTGTCCAGCCTGGATGCCTTCCTGGACCTTATTCGAAATCTCTTCCCTGAAAACCTT
GTCCAAGCCTGCTTTCAACAGATTCAAACAGTGACGAAGAAAGTCCTGGTTGCACCACCG
CCAGACGAGGAGGCCAACGCAACCAGCGCTGAAGTCTCTCTGTTGAACGAGACTGTGACT
GAGGTGCCGGAGGAGACTAAGATGGTTATCAAGAAGGGCCTGGAGTTCAAGGATGGGATG
AACGTCTTAGGTCTGATAGGGTTTTTCATTGCTTTTGGCATCGCTATGGGGAAGATGGGA
GATCAGGCCAAGCTGATGGTGGATTTCTTCAACATTTTGAATGAGATTGTAATGAAGTTA
GTGATCATGATCATGTGGTACTCTCCCCTGGGTATCGCCTGCCTGATCTGTGGAAAGATC
ATTGCAATCAAGGACTTAGAAGTGGTTGCTAGGCAACTGGGGATGTACATGGTAACAGTG
ATCATAGGCCTCATCATCCACGGGGGCATCTTTCTCCCCTTGATTTACTTTGTAGTGACC
AGGAAAAACCCCTTCTCCCTTTTTGCTGGCATTTTCCAAGCTTGGATCACTGCCCTGGGC
ACCGCTTCCAGTGCTGGAACTTTGCCTGTCACCTTTCGTTGCCTGGAAGAAAATCTGGGG
ATTGATAAGCGTGTGACTAGATTCGTCCTTCCTGTTGGAGCAACCATTAACATGGATGGT
ACAGCCCTTTATGAAGCGGTGGCCGCCATCTTTATAGCCCAAATGAATGGTGTTGTCCTG
GATGGAGGACAGATTGTGACTGTAAGCCTCACAGCCACCCTGGCAAGCGTCGGCGCGGCC
AGTATCCCCAGTGCCGGGCTGGTCACCATGCTCCTCATTCTGACAGCCGTGGGCCTGCCA
ACAGAGGACATCAGCTTGCTGGTGGCTGTGGACTGGCTGCTGGACAGGATGAGAACTTCA
GTCAATGTTGTGGGTGACTCTTTTGGGGCTGGGATAGTCTATCACCTCTCCAAGTCTGAG
CTGGATACCATTGACTCCCAGCATCGAGTGCATGAAGATATTGAAATGACCAAGACTCAA
TCCATTTATGATGACATGAAGAACCACAGGGAAAGCAACTCTAATCAATGTGTCTATGCT
GCACACAACTCTGTCATAGTAGATGAATGCAAGGTAACTCTGGCAGCCAATGGAAAGTCA
GCCGACTGCAGTGTTGAGGAAGAACCTTGGAAACGTGAGAAATAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
U03505

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_5_Locus:
11p13-p12

# Macromolecular_Interacting_Partner_5_SNPs:
rs752949; rs1042113; rs1570216; rs10768121; rs10768122; rs4508184; rs16927196; rs11821067; rs3088168; rs10488814; rs16927202; rs3812778; rs7936950; rs12361171; rs12292131; rs10742339; rs3829280; rs1043101; rs12294045; rs3812779; rs12360706; rs2012996; rs1320443; rs2421765; rs1923305; rs911562; rs2273689; rs1570214; rs1923302; rs2273688; rs1923300; rs1885345; rs1923292; rs2421764; rs2281633; rs1885346; rs1923298; rs1321677; rs4756217; rs3903687; rs10501137; rs3847619; rs3847620; rs4756224; rs4755408; rs3899569; rs927352; rs10768131; rs4755395; rs10836372; rs10768129; rs3847607; rs7130967; rs4756205; rs7105505; rs4756216; rs3891872; rs7110985; rs10836383; rs7116961; rs10836360; rs10488817; rs11033081; rs4756223; rs3794100; rs1885340; rs3818275; rs3847623; rs3847621; rs4144753; rs2421955; rs7102122; rs4755394; rs10836370; rs10836374; rs10742347; rs4756218; rs4459280; rs7934466; rs3847609; rs4756211; rs10836379; rs1885342; rs4144754; rs10768132; rs10768127; rs4756203; rs1475079; rs10836373; rs11033079; rs12574069; rs3794101; rs10501138; rs10836361; rs7114383; rs10836376; rs3829266; rs7119430; rs7105690; rs7930134; rs7110991; rs7925926; rs4144755; rs7127824; rs7103668; rs3843610; rs2421897; rs4756222; rs7928425; rs3794102; rs4756214; rs2901534; rs3895234; rs7121587; rs6484774; rs6484777; rs911561; rs1570226; rs7106060; rs7115246; rs7108848; rs12273644; rs4593985; rs1923293; rs7124363; rs2025111; rs4755407; rs3847612; rs1001525; rs10836375; rs4756208; rs4083481; rs1923294; rs1570225; rs7107752; rs10836382; rs10836358; rs1885347; rs1570227; rs12294219; rs7102331; rs1923291; rs7931664; rs1320442; rs10836357; rs3847618; rs3794099; rs4756220; rs7942698; rs6484786; rs16927209; rs12269851; rs7127728; rs12417279; rs7106813; rs11033064; rs4755398; rs10836384; rs6484773; rs10742346; rs1570215; rs10836368; rs11033096; rs3847611; rs10836377; rs11033061; rs12416720; rs10742345; rs4756229; rs10488815; rs7124645; rs6484778; rs11033063; rs11033100; rs2901605; rs3847604; rs7119850; rs7114489; rs10836395; rs11033099; rs1126356; rs7120564; rs16927393; rs4083482; rs10836393; rs3794097; rs1885341; rs3903688; rs4756213; rs1923307; rs3945930; rs16927361; rs3794103; rs11827417; rs4756210; rs11033071; rs7111949; rs4756226; rs6484784; rs3925877; rs1923299; rs16927212; rs10836389; rs10768133; rs4756204; rs11033091; rs1923287; rs12279038; rs4756212; rs3843609; rs17378105; rs6484781; rs11033065; rs4756219; rs11033098; rs6484785; rs6484779; rs10836380; rs2633077; rs3794087; rs12796856; rs6484780; rs10444271; rs7939959; rs2756223; rs1885343; rs6484776; rs9704794; rs2093377; rs4756221; rs1885344; rs3794096; rs11033113; rs6484771; rs4559666; rs12794012; rs3847614; rs7952042; rs11033073; rs2065030; rs764750; rs6484783; rs7129352; rs10742341; rs16927309; rs10836366; rs4755406; rs4237664; rs4287314; rs3847615; rs3911898; rs3847624; rs11033088; rs2281634; rs3794089; rs7104229; rs7927263; rs7931955; rs10836378; rs7101653; rs10836386; rs2145906; rs16927304; rs3847610; rs11033070; rs11033105; rs4756230; rs6484782; rs10836394; rs4755409; rs4756228; rs3915513; rs7105829; rs10836387; rs4534557; rs4756207; rs7114936; rs11033097; rs11033048; rs2273687; rs7122811; rs6484772; rs17379710; rs11033114; rs10836381; rs3945931; rs7929900; rs7938735; rs5028776; rs12226211; rs11033055; rs3847605; rs11033110; rs7939421; rs7947035; rs16927281; rs7941569; rs11033115; rs7939877; rs2756220; rs10488816; rs12365407; rs11524863; rs7111179; rs7934047; rs1923306; rs7934506; rs7115450; rs10836362; rs7942586; rs10836369; rs3794092; rs7111043; rs7940391; rs10836367; rs7131582; rs4110478; rs4582949; rs7946149; rs3847617; rs2756218; rs16927292; rs11826870; rs3847606; rs12274790; rs11033117; rs12273257; rs12420201; rs16927465; rs10836390; rs4755396; rs12271153; rs3794098; rs7937731; rs3901811; rs11033053; rs3794086; rs2756222; rs3794090; rs11033087; rs10768128; rs3847622; rs12294149; rs16927464; rs7936564; rs3794095; rs3930590; rs12290338; rs957350; rs7120037; rs3847608; rs16927255; rs11033086; rs3858469; rs1923297; rs11033054; rs16927412; rs11033112; rs3794093; rs3794085; rs4756209; rs10836388; rs12276085; rs7926910; rs7927975; rs10836392; rs12576375; rs10742340; rs7131025; rs7942395; rs16927218; rs16927296; rs11033093; rs7123447; rs7102654; rs10488818; rs7945809; rs12274991; rs7945276; rs7926777; rs1923290; rs7927023; rs16927404; rs7938934; rs12418812; rs12276739; rs11033092; rs10768126; rs12275544; rs7926298; rs11033052; rs11033084; rs3794091; rs1923304; rs1923301; rs10742344; rs16927439; rs2421770; rs3847613; rs3103239; rs11033095; rs3858470; rs16927214; rs7949171; rs7111055; rs3794094; rs2273686; rs2025110; rs10768123; rs7943314; rs10836391; rs11033104; rs16927220; rs12276318; rs7115318; rs4756215; rs1923295; rs1321701; rs11033045; rs4354668; rs10836356; rs10768120; rs7130385; rs12270460; rs1042109; rs34076319; rs35538744; rs34298257; rs1042110; rs35330053; rs34674989; rs11033046; rs34684140; rs34511376; rs35111216; rs12016674; rs36089385; rs16927206; rs35463073; rs10742338; rs35754526; rs35860537; rs12270176; rs35277432; rs34253208; rs2901536; rs11601487; rs10836371; rs5791049; rs34019360; rs34278007; rs12286827; rs11033076; rs35890685; rs11033094; rs41525047; rs10611656; rs7929821; rs12802986; rs3931458; rs10691833; rs34099702; rs12290517; rs4756227; rs12271412; rs7940317; rs34199031; rs35859924; rs2421766; rs35195460; rs10594944; rs3838796; rs35313408; rs4755402; rs11033089; rs5791048; rs11343973; rs35772202; rs35344226; rs10694959; rs12292906; rs35520902; rs2756219; rs12290877; rs34538353; rs11387745; rs34676740; rs33995901; rs10684715; rs12786603; rs11428049; rs34154849; rs11033106; rs7936311; rs3215690; rs4755399; rs11352014; rs34607922; rs11033111; rs11033058; rs36055801; rs12364497; rs10570359; rs7944233; rs41282922; rs11033077; rs12573878; rs5791053; rs11440191; rs34940757; rs7119804; rs7109108; rs7926964; rs7938263; rs12576364; rs11033057; rs10668268; rs3833775; rs12281268; rs34327791; rs12283268; rs35628724; rs34479062; rs34492921; rs34408622; rs3833776; rs34340929; rs7103913; rs12803138; rs12226024; rs34269233; rs11033078; rs36213305; rs11820710; rs35491492; rs3847616; rs35893832; rs35603234; rs12289615; rs2756221; rs4755404; rs35511500; rs34091906; rs11826069; rs3888947; rs3911975; rs2901535; rs35839899; rs35743304; rs11452697; rs35828529; rs2421768; rs10571677; rs4756225; rs35644978; rs3899568; rs10531923; rs34253859; rs35889672; rs2421767; rs35055326; rs11430577; rs4755405; rs34015269; rs11033072; rs5013411; rs11033080; rs11033090; rs5791046; rs4329664; rs41427147; rs34046951; rs5791047; rs11033109; rs7105719; rs33976778; rs34184336; rs12574573; rs33939708; rs12270238; rs34663542; rs1923289; rs5791054; rs11365357; rs12801230; rs9667283; rs3046423; rs11033059; rs12796282; rs11033067; rs34651424; rs11033066; rs35260784; rs5791051; rs41352148; rs7945449; rs3046407; rs34421352; rs12802008; rs34486840; rs11406743; rs36008789; rs35092350; rs7107530; rs6144299; rs36078766; rs7131319; rs34874565; rs34336534; rs5791045; rs28492370; rs35662460; rs12798956; rs28670615; rs35121562; rs35605334; rs35677995; rs11033060; rs16927226; rs7115510; rs4755401; rs35500428; rs11033074; rs7480049; rs3794088; rs34807346; rs7110965; rs35373254; rs11297103; rs4465348; rs7114260; rs10618218; rs2421769; rs1923288; rs11033085; rs35394058; rs4328187; rs34210296; rs4444055; rs34788307; rs34714367; rs10685002; rs28687628; rs4755400; rs3934208; rs11033049; rs2273685; rs11033068; rs11459739; rs10653501; rs9736291; rs28373337; rs4331068; rs34697063; rs35584173; rs11033101; rs35175359; rs7125980; rs28682526; rs12285197; rs5014708; rs12800790; rs28542229; rs5791050; rs34461926; rs12800978; rs7938986; rs6484775; rs34651636; rs12226511; rs11033056; rs35007682; rs4439485; rs34358833; rs4996048; rs7102975; rs3049545; rs7939095; rs28564012; rs10685003; rs11033062; rs35034122; rs11033075; rs34236815; rs34058137; rs16927367; rs4755403; rs4755397; rs34057298; rs11822372; rs35798636; rs12293849; rs11033083; rs35870659; rs11404520; rs34110770; rs7119728; rs11343016; rs35256511; rs5028775; rs4477419; rs35382627; rs33945912; rs11344053; rs7936164; rs34861808; rs34471197; rs33913005; rs7931233; rs7130500; rs11033118; rs36087730; rs35261093; rs34449927; rs34780937; rs1042115; rs10488813; rs10768118; rs10768119; rs10768134; rs10768137; rs10836355; rs10836364; rs11033043; rs11033050; rs11604850; rs1173920; rs1173921; rs12146523; rs12281679; rs12287327; rs12417518; rs12421963; rs12573961; rs12577445; rs12786497; rs12808695; rs16927467; rs16927469; rs1923296; rs1923303; rs2236272; rs2236273; rs2236274; rs2421823; rs3763888; rs3763889; rs4472913; rs4503504; rs4755410; rs4756201; rs4756202; rs4756206; rs4756231; rs4756232; rs7102949; rs7104662; rs7104693; rs7108747; rs7117625; rs7122176; rs7122374; rs7122389; rs7122640; rs736374; rs7940304; rs932634; rs932635; rs9633870

# Macromolecular_Interacting_Partner_5_General_References:
7521911; 8172925; 7522567; 9463476

# Macromolecular_Interacting_Partner_5_References:
Not Available

# Macromolecular_Interacting_Partner_6_ID:
8762

# Macromolecular_Interacting_Partner_6_Name:
Excitatory amino acid transporter 5

# Macromolecular_Interacting_Partner_6_Synonyms:
Solute carrier family 1 member 7; Retinal glutamate transporter

# Macromolecular_Interacting_Partner_6_Gene_Name:
SLC1A7

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Excitatory amino acid transporter 5
MVPHTILARGRDVCRRNGLLILSVLSVIVGCLLGFFLRTRRLSPQEISYFQFPGELLMRM
LKMMILPLVFSSLMSGLASLDAKTSSRLGVLTVAYYLWTTFMAVIVGIFMVSIIHPGSAA
QKETTEQSGKPIMSSADALLDLIRNMFPANLVEATFKQYRTKTTPVVKSPKVAPEEAPPR
RILIYGVQEENGSHVQNFALDLTPPPEVVYKSEPGTSDGMNVLGIVFFSATMGIMLGRMG
DSGGPLVSFCQCLNESVMKIVAVAVWYFPFGIVFLIAGKILEMDDPRAVGKKLGFYSVTV
VCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLIALATSSSSATLPITFKCLLENNH
IDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITGTAASIGAA
GIPQAGLVTMVIVLTSVGLPTDDITLIIGVDWALDRFRTMINVLGDALAAGIMAHICRKD
FARDTGTEKLLPCETKPVSLQEIVAAQQNGCVKSVAEASELTLGPTCPHHVPVQVERDEE
LPAASLNHCTIQISELETNV

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
560

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
60723

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
6.97

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
 Function:  transporter activity
Function:  organic acid transporter activity
Function:  carboxylic acid transporter activity
Function:  dicarboxylic acid transporter activity
Function:  sodium:dicarboxylate symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  organic acid transport
Process:  carboxylic acid transport
Process:  dicarboxylic acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_6_Specific_Function:
Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00375:SDF

# Macromolecular_Interacting_Partner_6_Signals:
1-34

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
17-37
60-80
94-114
217-237
260-280
300-320
330-350
372-392
414-434
457-477

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
2076762

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
EAA5_HUMAN (O00341)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SLC1A7

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SLC1A7

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:10945

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1683 bp
ATGGTGCCGCATACCATCTTGGCACGGGGGAGGGACGTGTGCAGGCGGAATGGACTCCTC
ATCCTGTCTGTGCTGTCTGTCATCGTGGGCTGCCTCCTCGGCTTCTTCTTGAGGACCCGG
CGCCTCTCACCACAGGAAATTAGTTACTTCCAGTTCCCCGGAGAGCTCCTGATGAGGATG
CTGAAGATGATGATCCTGCCACTGGTGTTCTCCAGCTTGATGTCCGGACTTGCCTCCCTG
GATGCCAAGACCTCTAGCCGCCTGGGCGTCCTCACCGTGGCGTACTACCTGTGGACCACC
TTCATGGCTGTCATCGTGGGCATCTTCATGGTCTCCATCATCCACCCAGGCAGCGCGGCC
CAGAAGGAGACCACGGAGCAGAGTGGGAAGCCCATCATGAGCTCAGCCGATGCCCTGTTG
GACCTCATCCGGAACATGTTCCCAGCCAACCTAGTAGAAGCCACATTCAAACAGTACCGC
ACCAAGACCACCCCAGTTGTCAAGTCCCCCAAGGTGGCACCAGAGGAGGCCCCTCCTCGG
CGGATCCTCATCTACGGGGTCCAGGAGGAGAATGGCTCCCATGTGCAGAACTTCGCCCTG
GACCTGACCCCGCCGCCCGAGGTCGTTTACAAGTCAGAGCCGGGCACCAGCGATGGCATG
AATGTGCTGGGCATCGTCTTCTTCTCTGCCACCATGGGCATCATGCTGGGCCGCATGGGT
GACAGCGGGGGCCCCCTGGTCAGCTTCTGCCAGTGCCTCAATGAGTCGGTCATGAAGATC
GTGGCGGTGGCTGTGTGGTATTTCCCCTTCGGCATTGTGTTCCTCATTGCGGGTAAGATC
CTGGAGATGGACGACCCCAGGGCCGTCGGCAAGAAGCTGGGCTTCTACTCAGTCACCGTG
GTGTGCGGGCTGGTGCTCCACGGGCTCTTTATCCTGCCCCTGCTCTACTTCTTCATCACC
AAGAAGAATCCCATCGTCTTCATCCGCGGCATCCTGCAGGCTCTGCTCATCGCGCTGGCC
ACCTCCTCCAGCTCAGCCACACTGCCCATCACCTTCAAGTGCCTGCTGGAGAACAACCAC
ATCGACCGGCGCATCGCTCGCTTCGTGCTGCCCGTGGGTGCCACCATCAACATGGACGGC
ACTGCGCTCTACGAGGCTGTGGCCGCCATCTTCATCGCCCAGGTCAACAACTACGAGCTG
GACTTTGGCCAGATCATCACCATCAGTATCACAGGCACTGCAGCCAGCATTGGGGCAGCT
GGCATCCCCCAGGCCGGCCTCGTCACCATGGTCATCGTGCTCACCTCCGTGGGACTGCCC
ACCGATGACATCACCCTCATCATTGGCGTTGACTGGGCTCTGGACCGTTTCCGCACCATG
ATTAACGTGCTGGGTGATGCGCTGGCAGCGGGGATCATGGCCCATATATGTCGGAAGGAT
TTTGCCCGGGACACAGGCACCGAGAAACTGCTGCCCTGCGAGACCAAGCCAGTGAGCCTC
CAGGAGATCGTGGCAGCCCAGCAGAATGGCTGTGTGAAGAGTGTAGCCGAGGCCTCCGAG
CTCACCCTGGGCCCCACCTGCCCCCACCACGTCCCCGTTCAAGTGGAGCGGGATGAGGAG
CTGCCCGCTGCGAGTCTGAACCACTGCACCATCCAGATCAGCGAGCTGGAGACCAATGTC
TGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
U76362

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_6_Locus:
1p32.3

# Macromolecular_Interacting_Partner_6_SNPs:
rs1288401; rs1288406; rs12129653; rs1288400; rs3737989; rs17108032; rs2279275; rs11581058; rs1288399; rs3737990; rs1769299; rs1288420; rs1288404; rs1288405; rs2790428; rs936642; rs1317433; rs1288371; rs3766804; rs3766793; rs946593; rs1288403; rs7541073; rs11206094; rs1679971; rs6666264; rs11206098; rs1679938; rs7516241; rs1288373; rs1288408; rs2306459; rs1288422; rs1288419; rs3816744; rs1288367; rs1288370; rs1679977; rs1383600; rs7534682; rs3820201; rs6694834; rs1295456; rs3766767; rs2242274; rs1769309; rs946591; rs11587058; rs3766776; rs3753597; rs3766781; rs2404210; rs1288369; rs1679910; rs1679966; rs1288413; rs3766780; rs1288375; rs1288379; rs4926585; rs1679970; rs3766807; rs3766785; rs11583585; rs1288372; rs2404211; rs3766794; rs1679911; rs1288421; rs6677094; rs3766775; rs6664572; rs3766779; rs1288412; rs11206103; rs768771; rs12138818; rs922682; rs3766791; rs6666283; rs1288385; rs11206092; rs17377135; rs2242275; rs3753596; rs1679962; rs11206104; rs1300169; rs7556017; rs4926957; rs899976; rs11588325; rs12031385; rs3766792; rs11582599; rs4926953; rs11206109; rs11206100; rs1288410; rs1679963; rs12089128; rs1288380; rs1288358; rs10465824; rs1288425; rs12057760; rs10888765; rs1288383; rs17377317; rs11206095; rs12097449; rs12087013; rs1679976; rs6688914; rs3766795; rs12076660; rs1769308; rs1288416; rs11206101; rs1288424; rs3766790; rs1288354; rs1288365; rs11206108; rs10465825; rs4926955; rs17108022; rs11206107; rs11206099; rs1620182; rs3766782; rs12071908; rs6672896; rs1288376; rs10888767; rs1679974; rs11206106; rs10888766; rs13375492; rs3737988; rs1299859; rs3766774; rs11206093; rs7543888; rs1679965; rs1629126; rs1288384; rs1769304; rs17107989; rs4926586; rs2806274; rs12402097; rs6688627; rs3766800; rs3766778; rs11590819; rs1288418; rs931158; rs12096200; rs3766769; rs1769287; rs11206097; rs899975; rs1769303; rs1679937; rs1288382; rs12406773; rs3753593; rs3753600; rs1288414; rs4926959; rs1383599; rs1288377; rs1679973; rs1679964; rs10465822; rs12741022; rs1288374; rs6660952; rs12095038; rs17107994; rs12124028; rs2806271; rs1288381; rs922683; rs1769302; rs12092559; rs1288357; rs11206096; rs1288402; rs7530351; rs3753594; rs12403742; rs1288415; rs10465823; rs3766772; rs6694555; rs2790429; rs17108014; rs1769306; rs1679972; rs6588462; rs1288363; rs1288398; rs7549922; rs12042673; rs11206114; rs11206112; rs11206115; rs17107896; rs34418279; rs6701113; rs11206110; rs11206113; rs11206111; rs36059472; rs17850871; rs12021744; rs17850870; rs41312042; rs6658725; rs1047741; rs41298519; rs12726256; rs1769301; rs12738846; rs35659487; rs2306460; rs3835517; rs3766806; rs36087892; rs12132835; rs34240962; rs1288359; rs12094915; rs11206105; rs10664463; rs1769289; rs12738223; rs6678482; rs12031870; rs35072127; rs35847858; rs35003235; rs10649406; rs11402739; rs12751682; rs28475307; rs10582647; rs35401115; rs3121057; rs34256281; rs35058173; rs35193774; rs35757700; rs36097481; rs5774135; rs4926954; rs34450501; rs1629337; rs12759858; rs35617939; rs35966763; rs28545024; rs34866302; rs2929070; rs12733284; rs28497685; rs1021067; rs12759179; rs7555927; rs28665727; rs33933889; rs34043122; rs35510331; rs12736018; rs12097556; rs10465802; rs34963705; rs3766771; rs36059117; rs3091279; rs7414263; rs12028538; rs34978992; rs12751209; rs12753746; rs2929071; rs1288407; rs34800062; rs946592; rs35707549; rs28674862; rs2998095; rs3820202; rs28572521; rs35101975; rs34995823; rs35812030; rs34924909; rs4926584; rs12073825; rs34322627; rs34180199; rs12029289; rs12022300; rs35022560; rs6694665; rs28550100; rs34100876; rs36026049; rs11585963; rs12132883; rs12032008; rs35660302; rs6667002; rs10465826; rs12740055; rs28634935; rs10644085; rs11488222; rs5774136; rs35375670; rs35011578; rs12028535; rs1288355; rs6693952; rs11269357; rs1288366; rs12733497; rs34654701; rs12759482; rs12140504; rs34010895; rs2860608; rs1288417; rs35161056; rs12045217; rs12094913; rs34913378; rs12759321; rs34431109; rs36062616; rs36154040; rs36014120; rs28570358; rs34127376; rs17376904; rs35238020; rs6657444; rs34203701; rs936641; rs35112358; rs1288356; rs1769310; rs28697953; rs11485585; rs2998097; rs2998094; rs12144331; rs12136699; rs2929072; rs12737414; rs12760665; rs1769307; rs10582648; rs5774137; rs3766808; rs35128981; rs10537909; rs12028550; rs12240252; rs1288411; rs1679940; rs12032066; rs35336798; rs4926587; rs1288409; rs13376214; rs35499060; rs9436922; rs12028537; rs11299691; rs12757824; rs12067568; rs11417607; rs28850943; rs1288360; rs28647213; rs12753885; rs11424356; rs12751971; rs28507205; rs10465801; rs12126177; rs12753377; rs35110975; rs1288368; rs35957126; rs10888764; rs35777803; rs1288423; rs1626215; rs3121906; rs35838350; rs35036005; rs12760508; rs33958729; rs35644846; rs12736292; rs33959075; rs2998096; rs28546957; rs35258798; rs7545160; rs12031872; rs12725485; rs1679967; rs12752012; rs1288378; rs35213028; rs9436921; rs36025187; rs28627531; rs3766802; rs35778417; rs12733486; rs12062869; rs35061782; rs2306461; rs35057194; rs12751231; rs35599577; rs12737273; rs34925357; rs35697775; rs12119872; rs6664795; rs35816447; rs34983198; rs28367301; rs2998093; rs35175757; rs28451553; rs35867575; rs11206091; rs28418579; rs12043642; rs34669865; rs35707584; rs12040550; rs12028726; rs12744752; rs12727811; rs1288364; rs12750628; rs35866873; rs34798360; rs1001513; rs10157941; rs10888768; rs10888771; rs11206087; rs11206088; rs11206089; rs11206116; rs11206117; rs11579966; rs11803838; rs11804391; rs12070099; rs12074137; rs12074944; rs12123958; rs12143903; rs12567021; rs12723536; rs12745973; rs1288388; rs1288389; rs1288392; rs1288393; rs1288394; rs1288395; rs1288396; rs1288397; rs1320594; rs1628297; rs1679930; rs1679933; rs1679934; rs1679936; rs1679941; rs17107864; rs17107877; rs1769318; rs1769319; rs1769320; rs2282340; rs2486634; rs2806272; rs2806273; rs3121058; rs34163250; rs34248789; rs4576613; rs6691956; rs6696614; rs7552743; rs7553128; rs899973; rs899974; rs946590

# Macromolecular_Interacting_Partner_6_General_References:
9108121

# Macromolecular_Interacting_Partner_6_References:
Not Available

# Macromolecular_Interacting_Partner_7_ID:
8842

# Macromolecular_Interacting_Partner_7_Name:
Excitatory amino acid transporter 4

# Macromolecular_Interacting_Partner_7_Synonyms:
Solute carrier family 1 member 6; Sodium-dependent glutamate/aspartate transporter

# Macromolecular_Interacting_Partner_7_Gene_Name:
SLC1A6

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Excitatory amino acid transporter 4
MSSHGNSLFLRESGQRLGRVGWLQRLQESLQQRALRTRLRLQTMTLEHVLRFLRRNAFIL
LTVSAVVIGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASLD
NKATGRMGMRAAVYYMVTTIIAVFIGILMVTIIHPGKGSKEGLHREGRIETIPTADAFMD
LIRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGASMPPPFSVENGTSFLENV
TRALGTLQEMLSFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLN
EAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPL
IYFLVTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGA
TVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVL
TSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQEAELTLPSLG
KPYKSLMAQEKGASRGRGGNESAM

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
564

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
61567

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
9.54

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
 Function:  transporter activity
Function:  organic acid transporter activity
Function:  carboxylic acid transporter activity
Function:  dicarboxylic acid transporter activity
Function:  sodium:dicarboxylate symporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  organic acid transport
Process:  carboxylic acid transport
Process:  dicarboxylic acid transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_7_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_7_Specific_Function:
Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00375:SDF

# Macromolecular_Interacting_Partner_7_Signals:
Not Available

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
56-76
99-119
133-153
265-285
306-326
345-365
370-390
418-438
460-480
481-501

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
930337

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
EAA4_HUMAN (P48664)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
SLC1A6

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
SLC1A6

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:10944

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1695 bp
ATGAGCAGCCATGGCAACAGCCTGTTCCTTCGGGAGAGCGGCCAGCGGCTGGGCCGGGTG
GGCTGGCTGCAGCGGCTGCAGGAAAGCCTGCAGCAGAGAGCACTGCGCACGCGCCTGCGC
CTGCAGACCATGACCCTCGAGCACGTGCTGCGCTTCCTGCGCCGAAACGCCTTCATTCTG
CTGACGGTCAGCGCCGTGGTCATTGGGGTCAGCCTGGCCTTTGCCCTGCGCCCATATCAG
CTCACCTACCGCCAGATCAAGTACTTCTCTTTTCCTGGAGAGCTTCTGATGAGGATGCTG
CAGATGCTGGTGTTACCTCTCATTGTCTCCAGCCTGGTCACAGGTATGGCATCCCTGGAC
AACAAGGCCACGGGGCGGATGGGGATGCGGGCAGCTGTGTACTACATGGTGACCACCATC
ATCGCGGTCTTCATCGGCATCCTCATGGTCACCATCATCCATCCCGGGAAGGGCTCCAAG
GAGGGGCTGCACCGGGAGGGCCGGATCGAGACCATCCCCACAGCTGATGCCTTCATGGAC
CTGATCAGAAATATGTTTCCACCAAACCTTGTGGAGGCCTGCTTCAAACAGTTCAAGACG
CAGTACAGCACGAGGGTGGTAACCAGGACCATGGTGAGGACAGAGAACGGGTCTGAGCCG
GGTGCCTCCATGCCTCCTCCATTCTCAGTGGAGAACGGAACCAGCTTCCTGGAAAATGTC
ACTCGGGCCTTGGGTACCCTGCAGGAGATGCTGAGCTTTGAGGAGACTGTACCCGTGCCT
GGCTCCGCCAATGGCATCAACGCCCTGGGCCTCGTGGTCTTCTCTGTGGCCTTTGGGCTG
GTCATTGGTGGCATGAAACACAAGGGCAGAGTCCTCAGGGACTTCTTCGACAGCCTCAAT
GAGGCTATTATGAGGCTGGTGGGCATCATTATCTGGTATGCACCTGTGGGCATCCTGTTC
CTGATTGCTGGGAAGATTCTGGAGATGGAAGACATGGCCGTCCTGGGGGGTCAGCTGGGC
ATGTACACCCTGACCGTCATCGTGGGCCTGTTCCTCCATGCCGGCATTGTCCTTCCCCTC
ATCTACTTCCTCGTCACTCACCGGAACCCCTTCCCCTTCATTGGGGGCATGCTACAAGCC
CTCATCACCGCTATGGGCACGTCTTCCAGCTCGGCAACGCTGCCCATCACCTTCCGCTGC
CTGGAGGAGGGCCTGGGTGTGGACCGCCGCATCACCAGGTTCGTCCTGCCCGTGGGCGCC
ACGGTCAACATGGATGGCACTGCCCTCTACGAGGCCCTGGCTGCCATCTTCATTGCTCAA
GTTAACAACTACGAGCTCAACCTGGGTCAGATCACAACCATCAGCATCACGGCCACAGCA
GCCAGTGTTGGGGCTGCTGGCATCCCCCAGGCGGGTCTGGTCACCATGGTCATTGTGCTT
ACGTCGGTCGGCTTGCCCACGGAAGACATCACGCTCATCATCGCCGTGGACTGGTTCCTT
GACCGGCTTCGCACAATGACCAACGTACTGGGGGACTCAATTGGAGCGGCCGTCATCGAG
CACTTGTCTCAGCGGGAGCTGGAGCTTCAGGAAGCTGAGCTTACCCTCCCCAGCCTGGGG
AAACCCTACAAGTCCCTCATGGCACAGGAGAAGGGGGCATCCCGGGGACGGGGAGGCAAC
GAGAGTGCTATGTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
U18244

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_7_Locus:
19p13.12

# Macromolecular_Interacting_Partner_7_SNPs:
rs3746295; rs16980148; rs2301853; rs12461006; rs2074615; rs2285980; rs12460353; rs873599; rs6511990; rs2285979; rs10417793; rs10403853; rs2189666; rs11671748; rs3803927; rs12460642; rs8108809; rs10408350; rs10415969; rs10407669; rs7253547; rs8108794; rs16980150; rs3815187; rs10415537; rs10406718; rs3827000; rs10410303; rs4511655; rs10401807; rs8109792; rs8112689; rs11668879; rs12463072; rs10403281; rs8113595; rs2097837; rs11669603; rs3746293; rs2189665; rs12972726; rs11673425; rs757465; rs10410180; rs7251228; rs10410626; rs2214603; rs2189664; rs2269913; rs12462958; rs7247183; rs12973581; rs10427099; rs1106738; rs4393693; rs2097836; rs7247531; rs11666283; rs7250478; rs16980152; rs12232794; rs11666968; rs4514810; rs2214602; rs7255650; rs757466; rs8105884; rs739962; rs2011112; rs3761099; rs8103212; rs2011132; rs8106695; rs739961; rs10419606; rs739963; rs7256150; rs3827006; rs3827005; rs3761100; rs10420206; rs3827007; rs10414644; rs35468001; rs3746294; rs34797512; rs3803928; rs5827266; rs10417230; rs10402958; rs34710555; rs34847096; rs35375672; rs36065519; rs35846543; rs2269914; rs12978810; rs2366859; rs12979472; rs36102075; rs34132116; rs34489581; rs12973102; rs10402960; rs2301854; rs10417023; rs35298524; rs35950893; rs2214601; rs12986049; rs34907139; rs7252057; rs12981490; rs5827267; rs12460957; rs10414225; rs12973558; rs35305816; rs35166598; rs12985848; rs11665949; rs12981997; rs12459441; rs12972461; rs34732384; rs3827002; rs35756560; rs35668831; rs3827004; rs12980319; rs3761101; rs5827264; rs3827003; rs3761098; rs5827265; rs11671614; rs11671616; rs34226419; rs34438988; rs28442191; rs13346179; rs1007503; rs1007504; rs1007505; rs11672838; rs1548543; rs1548545; rs16980139; rs1859384; rs4549003; rs7247514; rs7250612; rs8108343; rs8111088; rs8113325

# Macromolecular_Interacting_Partner_7_General_References:
7791878

# Macromolecular_Interacting_Partner_7_References:
Not Available

End of HMDB00191

Beginning of HMDB00192
# Accession_No:
HMDB00192

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-10 16:01:18

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
L-Cystine

# Description:
Cystine is an oxidized dimeric form of cysteine. It is formed by linking two cysteine residues via a disulfide bond (cys-S-S-cys) between the -SH groups.  Cystine is found in high concentrations in the cells of the immune system, skeletal and connective tissues, skin, digestive enzymes, and in hair. Hair and skin are 10-14% cystine. Cystine is the preferred form of cysteine for the synthesis of glutathione in cells involved in the immune function including macrophages and astrocytes. Lymphocytes and neurons prefer cysteine for glutathione production. Optimizing glutathione levels in macrophages and astrocytes with cystine allows these cells to provide cysteine to lymphocytes and neurons directly upon demand. (http://en.wikipedia.org/wiki/Cystine)

# Synonyms:
(-)-Cystine; (R-(R*,R*))-3,3'-Dithiobis; 2-Amino-3-[(2-amino-2-carboxyethyl)dithio]propanoate; 2-Amino-3-[(2-amino-2-carboxyethyl)dithio]propanoic acid; 2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoate; 2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid; 3,3'-Dithiobis; 3,3'-Dithiodialanine; 3,3'-dithiobis-L-Alanine; 3,3'-dithiobis[2-amino-[R-(R*,R*)]-Propanoate; 3,3'-dithiobis[2-amino-[R-(R*,R*)]-Propanoic acid; Bis(b-amino-b-carboxyethyl) disulfide; Cysteine disulfide; Cystin; Cystine; Cystine acid; D(+)-3,3'-Dithiobis(2-aminopropanoate; D(+)-3,3'-Dithiobis(2-aminopropanoic acid; Dicysteine; Gelucystine; L-(-)-Cystine; L-Cysteine disulfide; L-Cystin; Oxidized L-cysteine; [R-(R*,R*)]-3,3'-Dithiobis; b,b'-Diamino-b,b'-dicarboxydiethyl disulfide; b,b'-Dithiodialanine; beta,beta'-Dithiobisalanine; beta,beta'-Dithiodialanine; l-Cystine; Bis(b-amino-beta-carboxyethyl) disulfide

# Chemical_IUPAC_Name:
2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid

# Chemical_Formula:
C6H12N2O4S2

# Chemical_Structure:
tbl_chemical:::HMDB00192_ZOOM.png:::11928324398171653

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00192_THUMB.png:::119283243786377118

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids; Nitrogenous Compounds

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
disulfide; primary amine; primary aliphatic amine (alkylamine); carboxylic acid; alpha-aminoacid

# Taxonomy_Biofunction:
Essential amino acid

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
240.02385

# Molecular_Weight_Avg:
240.30048

# Smiles_String_isomeric:
N[C@@H](CSSC[C@H](N)C(O)=O)C(O)=O

# Smiles_String_canonical:
NC(CSSCC(N)C(O)=O)C(O)=O

# KEGG_Compound_ID:
C00491

# BioCyc_ID:
CYSTINE

# PubChem_CID:
67678

# PubChem_SID:
8191444; 3132637; 3774; 841453; 10527686; 209796; 8143450

# OMIM_ID:
215720; 219750; 219800; 220100; 222350; 222470; 222690; 238200; 310600; 606407

# Metagene_ID:
Not Available

# BiGG_ID:
35134

# Wikipedia_ID:
Cystine

# METLIN_ID:
5207

# Ref_ID:
12414905; 16091433; 14992292; 8424686; 15879904; 1275714; 12923163; 12444206; 16047489; 8890399; 15455621; 2026685; 8713992; 7493346; 12834252; 16200192; 486533; 3794387; 16686727; 12520765

# ChEBI_ID:
16283

# CAS_Registry_Number:
56-89-3

# InChI:
InChI=1/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1

# Synthesis_Reference:
Org. Synth., Coll. Vol., 1, 1932, 188; Axelsson, B.S. et al., J.C.S. Perkin 1, 1994

# Melting_Point:
260.5 oC

# Melting_Point_predicted:
53.2 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.19 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
16.8 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-5.08 [CHMELIK,J ET AL. (1991)]

# LogP_predicted:
-3.16 [Predicted by ALOGPS]; -5.5 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::L-Cystine.pdf:::1132562214429884523

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00192.mol:::1180720965771822816

# SDF_File_[Text]:
tbl_chemical:::HMDB00192.sdf:::119283243390088924

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00192.pdb:::11928324364747807

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041014_P00_05_HW_1DP_presat.png:::115092344685144015

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041014_P00_05_HW_1DP_presat.zip:::115092344687597343

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041014_P00_05_HW_1DP_Assigned.png:::115705648312056443

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041014_P00_05_HW_2DHSQC_569.png:::11478148848693982

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041014_P00_05_HW_2DHSQC_569.zip:::114781488487579859

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041014_P00_05_HW_2DHSQC_569_Assigned.png:::114781488503382687

# Predicted_H_NMR_Spectrum:
tbl_chemical:::HMDB00192.gif:::1180047422536587481

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00192_peaks.txt:::1180047326528766692

# Predicted_C_NMR_Spectrum:
tbl_chemical:::HMDB00192_C.gif:::1180047470632729031

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00192_peaks.txt:::1180047374692336554

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00192L.png:::11755526195647981; Medium Energy:tbl_ms:::HMDB00192M.png:::117555267073733315; High Energy:tbl_ms:::HMDB00192H.png:::117555270938295310

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000035.png:::116890823634370766

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000035.txt:::116890823634387455

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000035.png:::116890823603177215

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000035.txt:::116890823634381581

# Cellular_Location:
Cytoplasm; Extracellular

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	3.618 (1.316-5.921)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Urine	10.05 +/- 28.34	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	2026685
Blood	130.0 +/- 20.0	umol/L	Newborn:0-30_days_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	91.0 +/- 20.0	umol/L	Children:1-13_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	96.0 +/- 19.0	umol/L	Children:1-13_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	118.0 +/- 17.0	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	109.0 +/- 24.0	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 92. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	87.0 +/- 13.0	umol/L	Children:1-13_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 93. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	109.0 +/- 18.0	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 93. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	107.0 +/- 23.0	umol/L	Adult:>18_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 93. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	0.1 +/- 0.1	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	0.29 +/- 0.27	uM	Adult:>18_yrs_old	Both	Normal	12834252


# Concentration_[Abnormal]:
Urine	> 117	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Cystinuria	8890399
Blood	28.6 (24.2-33.0)	umol/L	Adult:>18_yrs_old	Both	Juvenile myoclonic epilepsy (JME)	14992292
Blood	30.1 (24.5-35.7)	umol/L	Adult:>18_yrs_old	Both	Acute seizures	14992292
Blood	37.2 (34.6-39.8)	umol/L	Adult:>18_yrs_old	Both	Refractory localization-related epilepsy (RLE)	14992292
Cerebrospinal_Fluid(CSF)	0.31 +/- 0.06	uM	Adult:>18_yrs_old	Both	Parkinson's Disease	12834252


# Associated_Disorders:
Acute seizures; Cystinosis; Cystinuria; Hypercholesterolemia; Juvenile Myoclonic Epilepsy (JME); Parkinson's Disease; Refractory localization-related epilepsy (RLE)

# Pathway_Names:
Methionine metabolism

# Pathway_Images:
Methionine_Metabolism.jpg

# KEGG_Images:
map00271

# Pathway_Graphs:
Methionine_Metabolism_Graph.jpg

# Pathway_SBMLs:
Methionine_Metabolism.xml

# Metabolic_Enzyme_1_ID:
5789

# Metabolic_Enzyme_1_Name:
Cystathionine gamma-lyase

# Metabolic_Enzyme_1_Synonyms:
Gamma-cystathionase

# Metabolic_Enzyme_1_Gene_Name:
CTH

# Metabolic_Enzyme_1_Protein_Sequence:
>Cystathionine gammalyase
MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEY
SRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRY
FRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHG
DIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQ
NSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQH
ELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVL
KNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS

# Metabolic_Enzyme_1_Number_of_Residues:
405

# Metabolic_Enzyme_1_Molecular_Weight:
44508

# Metabolic_Enzyme_1_Theoretical_pI:
6.69

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
L-cystathionine + H(2)O = L-cysteine + NH(3) + 2-oxobutanoate

# Metabolic_Enzyme_1_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00271  Methionine metabolism;
 map00272  Cysteine metabolism;
 map00450  Selenoamino acid metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_1_Reaction:
L-cystathionine + H2O = L-cysteine + ammonia + 2-oxobutanoate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01053:Cys_Met_Meta_PP

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 4.4.1.1

# Metabolic_Enzyme_1_GenBank_ID_Protein:
262476

# Metabolic_Enzyme_1_SwissProt_ID:
CGL_HUMAN (P32929)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
CTH

# Metabolic_Enzyme_1_Geneatlas_id:
CTH

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2501

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1218 bp
ATGCAGGAAAAAGACGCCTCCTCACAAGGTTTCCTGCCACACTTCCAACATTTCGCCACG
CAGGCGATCCATGTGGGCCAGGATCCGGAGCAATGGACCTCCAGGGCTGTAGTGCCCCCC
ATCTCACTGTCCACCACGTTCAAGCAAGGGGCGCCTGGCCAGCACTCGGGTTTTGAATAT
AGCCGTTCTGGAAATCCCACTAGGAATTGCCTTGAAAAAGCAGTGGCAGCACTGGATGGG
GCTAAGTACTGTTTGGCCTTTGCTTCAGGTTTAGCAGCCACTGTAACTATTACCCATCTT
TTAAAAGCAGGAGACCAAATTATTTGTATGGATGATGTGTATGGAGGTACAAACAGGTAC
TTCAGGCAAGTGGCATCTGAATTTGGATTAAAGATTTCTTTTGTTGATTGTTCCAAAATC
AAATTACTAGAGGCAGCAATTACACCAGAAACCAAGCTTGTTTGGATCGAAACCCCCACA
AACCCCACCCAGAAGGTGATTGACATTGAAGGCTGTGCACATATTGTCCATAAGCATGGA
GACATTATTTTGGTCGTGGATAACACTTTTATGTCACCATATTTCCAGCGCCCTTTGGCT
CTGGGAGCTGATATTTCTATGTATTCTGCAACAAAATACATGAATGGCCACAGTGATGTT
GTAATGGGCCTGGTGTCTGTTAATTGTGAAAGCCTTCATAATAGACTTCGTTTCTTGCAA
AACTCTCTTGGAGCAGTTCCATCTCCTATTGATTGTTACCTCTGCAATCGAGGTCTGAAG
ACTCTACATGTCCGAATGGAAAAGCATTTCAAAAACGGAATGGCAGTTGCCCAGTTCCTG
GAATCTAATCCTTGGGTAGAAAAGGTTATTTATCCTGGGCTGCCCTCTCATCCACAGCAT
GAGTTGGTGAAGCGTCAGTGTACAGGTTGTACAGGGATGGTCACCTTTTATATTAAGGGC
ACTCTTCAGCATGCTGAGATTTTCCTCAAGAACCTAAAGCTATTTACTCTGGCCGAGAGC
TTGGGAGGATTCGAAAGCCTTGCTGAGCTTCCGGCAATCATGACTCATGCATCAGTTCTT
AAGAATGACAGAGATGTCCTTGGAATTAGTGACACACTGATTCGACTTTCTGTGGGCTTA
GAGGATGAGGAAGACCTACTGGAAGATCTAGATCAAGCTTTGAAGGCAGCACACCCTCCA
AGTGGAATTCACAGCTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
S52784

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_1_Locus:
1p31.1

# Metabolic_Enzyme_1_SNPs:
rs1021737; rs17131292; rs535112; rs672203; rs663649; rs515064; rs473334; rs681475; rs481654; rs1145920; rs525919; rs6413469; rs4650049; rs525276; rs475263; rs12723350; rs543860; rs1145919; rs487773; rs490574; rs559062; rs501939; rs577476; rs6413471; rs482291; rs3767205; rs11800827; rs12047791; rs12566819; rs35173672; rs6413472; rs1831868; rs34538135; rs35523269; rs35441160; rs828355; rs17131305; rs35356635; rs608609; rs35864483; rs35242276; rs10889869; rs12037405; rs12030275; rs36032119; rs34044393; rs6413470; rs7418870; rs17131304; rs35873591; rs1831869; rs17131302; rs6693082; rs663465; rs648743; rs6677781; rs583316; rs6413468; rs12733999; rs3806385; rs17131290; rs584229; rs28595301; rs41305638; rs28498802; rs12134794; rs4650048; rs11295998; rs10583561; rs17131300; rs6703826; rs7367528; rs5775007; rs34806645; rs41313347; rs12134791; rs35200485; rs11589868; rs12134763; rs35769653; rs6657511; rs10607278; rs12141277; rs34046663; rs11413197; rs34328255; rs6657715; rs34566720; rs34937471; rs34141704; rs35782843; rs5775006; rs4323657; rs13374865; rs12134858; rs12753345; rs562660; rs6413473; rs4649915; rs12133065; rs35606808; rs35199704; rs12134857; rs12124009; rs34612780; rs34825234; rs36059149; rs34311111; rs34465384; rs36065609; rs11590089; rs11803055; rs12026422; rs12063280; rs12093763; rs12561944; rs12728599; rs1697388; rs17131275; rs17131276; rs17131277; rs17131278; rs17131280; rs17131282; rs17131285; rs17131286; rs17131287; rs17131288; rs17131289; rs17131312; rs2151540; rs3856027; rs3856028; rs4650047; rs4650050; rs482843; rs508310; rs517500; rs555671; rs561926; rs618531; rs6424386; rs649346; rs664051; rs7515490; rs7537371; rs7549628

# Metabolic_Enzyme_1_General_References:
1339280; 12574942

# Metabolic_Enzyme_1_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8471

# Macromolecular_Interacting_Partner_1_Name:
Cystine/glutamate transporter

# Macromolecular_Interacting_Partner_1_Synonyms:
Amino acid transport system xc-; xCT; Calcium channel blocker resistance protein CCBR1

# Macromolecular_Interacting_Partner_1_Gene_Name:
SLC7A11

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Cystine/glutamate transporter
MVRKPVVSTISKGGYLQGNVNGRLPSLGNKEPPGQEKVQLKRKVTLLRGVSIIIGTIIGA
GIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYILEVFGP
LPAFVRVWVELLIIRPAATAVISLAFGRYILEPFFIQCEIPELAIKLITAVGITVVMVLN
SMSVSWSARIQIFLTFCKLTAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFY
YGMYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEELLLS
NAVAVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHV
RKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYKCPDMHRP
FKVPLFIPALFSFTCLFMVALSLYSDPFSTGIGFVITLTGVPAYYLFIIWDKKPRWFRIM
SEKITRTLQIILEVVPEEDKL

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
501

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
55424

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
9.51

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
 Function:  amino acid permease activity
Function:  transporter activity
Function:  amine transporter activity
Function:  amino acid transporter activity
Function:  amino acid-polyamine transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  amine transport
Process:  amino acid transport
 ||
>>>
 Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_1_Specific_Function:
Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00324:AA_permease

# Macromolecular_Interacting_Partner_1_Signals:
Not Available

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
44-64
75-95
114-134
159-179
190-210
235-255
266-286
318-338
365-385
388-408
423-443
450-470

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
5668545

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
XCT_HUMAN (Q9UPY5)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
SLC7A11

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
SLC7A11

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:11059

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1506 bp
ATGGTCAGAAAGCCTGTTGTGTCCACCATCTCCAAAGGAGGTTACCTGCAGGGAAATGTT
AACGGGAGGCTGCCTTCCCTGGGCAACAAGGAGCCACCTGGGCAGGAGAAAGTGCAGCTG
AAGAGGAAAGTCACTTTACTGAGGGGAGTCTCCATTATCATTGGCACCATCATTGGAGCA
GGAATCTTCATCTCTCCTAAGGGCGTGCTCCAGAACACGGGCAGCGTGGGCATGTCTCTG
ACCATCTGGACGGTGTGTGGGGTCCTGTCACTATTTGGAGCTTTGTCTTATGCTGAATTG
GGAACAACTATAAAGAAATCTGGAGGTCATTACACATATATTTTGGAAGTCTTTGGTCCA
TTACCAGCTTTTGTACGAGTCTGGGTGGAACTCCTCATAATACGCCCTGCAGCTACTGCT
GTGATATCCCTGGCATTTGGACGCTACATTCTGGAACCATTTTTTATTCAATGTGAAATC
CCTGAACTTGCGATCAAGCTCATTACAGCTGTGGGCATAACTGTAGTGATGGTCCTAAAT
AGCATGAGTGTCAGCTGGAGCGCCCGGATCCAGATTTTCTTAACCTTTTGCAAGCTCACA
GCAATTCTGATAATTATAGTCCCTGGAGTTATGCAGCTAATTAAAGGTCAAACGCAGAAC
TTTAAAGACGCGTTTTCAGGAAGAGATTCAAGTATTACGCGGTTGCCACTGGCTTTTTAT
TATGGAATGTATGCATATGCTGGCTGGTTTTACCTCAACTTTGTTACTGAAGAAGTAGAA
AACCCTGAAAAAACCATTCCCCTTGCAATATGTATATCCATGGCCATTGTCACCATTGGC
TATGTGCTGACAAATGTGGCCTACTTTACGACCATTAATGCTGAGGAGCTGCTGCTTTCA
AATGCAGTGGCAGTGACCTTTTCTGAGCGGCTACTGGGAAATTTCTCATTAGCAGTTCCG
ATCTTTGTTGCCCTCTCCTGCTTTGGCTCCATGAACGGTGGTGTGTTTGCTGTCTCCAGG
TTATTCTATGTTGCGTCTCGAGAGGGTCACCTTCCAGAAATCCTCTCCATGATTCATGTC
CGCAAGCACACTCCTCTACCAGCTGTTATTGTTTTGCACCCTTTGACAATGATAATGCTC
TTCTCTGGAGACCTCGACAGTCTTTTGAATTTCCTCAGTTTTGCCAGGTGGCTTTTTATT
GGGCTGGCAGTTGCTGGGCTGATTTATCTTCGATACAAATGCCCAGATATGCATCGTCCT
TTCAAGGTGCCACTGTTCATCCCAGCTTTGTTTTCCTTCACATGCCTCTTCATGGTTGCC
CTTTCCCTCTATTCGGACCCATTTAGTACAGGGATTGGCTTCGTCATCACTCTGACTGGA
GTCCCTGCGTATTATCTCTTTATTATATGGGACAAGAAACCCAGGTGGTTTAGAATAATG
TCAGAGAAAATAACCAGAACATTACAAATAATACTGGAAGTTGTACCAGAAGAAGATAAG
TTATGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AB026891

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_1_Locus:
4q28-q32

# Macromolecular_Interacting_Partner_1_SNPs:
rs4479754; rs6838248; rs35701885; rs7674870; rs13144383; rs4560461; rs1018278; rs4580699; rs7695989; rs4241940; rs4241939; rs6852562; rs4863772; rs6537201; rs4241938; rs6848356; rs7682497; rs6854381; rs4863771; rs4346698; rs6537262; rs6537245; rs6537243; rs4616810; rs4461565; rs6832143; rs6537244; rs6851845; rs4604102; rs4450980; rs4330397; rs4635863; rs6854495; rs4429772; rs4602539; rs4501269; rs6811062; rs4295318; rs4863768; rs7667390; rs7663187; rs11723658; rs5028340; rs17050206; rs11727731; rs13137929; rs6823642; rs7666936; rs7685529; rs4863767; rs6832329; rs11728841; rs11100834; rs12506333; rs11726394; rs4504306; rs1513770; rs11944083; rs2203292; rs3935420; rs10016559; rs10011428; rs11731957; rs4432801; rs1018279; rs11941210; rs5010683; rs11734488; rs6823797; rs4131888; rs5028339; rs12507560; rs5028338; rs35509920; rs7670361; rs4458505; rs6826686; rs6842328; rs6831157; rs4597880; rs10519451; rs11726904; rs13123358; rs11100856; rs13141329; rs4277825; rs13434884; rs12648268; rs11728401; rs6849136; rs11100852; rs11726938; rs4863770; rs11722075; rs11723941; rs7691115; rs7669379; rs12644169; rs12648155; rs4495092; rs4285139; rs2037027; rs11100861; rs7674749; rs4863541; rs7687893; rs4863769; rs6856980; rs10007843; rs10023744; rs4605709; rs6836568; rs11100854; rs12501178; rs10013651; rs907846; rs6842877; rs4346696; rs7663737; rs7688870; rs11942121; rs4353954; rs4343770; rs28364686; rs7442098; rs34757167; rs35186416; rs7436071; rs28475437; rs35902409; rs34210801; rs35238413; rs41280525; rs28535605; rs35108180; rs35668334; rs34738111; rs35743443; rs35233426; rs35863021; rs35848384; rs35603182; rs11558459; rs13120371; rs1828731; rs11721615; rs13102641; rs34634857; rs4863776; rs33981028; rs34133691; rs35538364; rs36084343; rs35871663; rs34001412; rs34499486; rs9991050; rs35902152; rs34428505; rs34564510; rs11429332; rs1398923; rs11285067; rs2314121; rs10659044; rs35797835; rs2037026; rs33971395; rs5862368; rs35822309; rs35216782; rs11363996; rs1828730; rs34693752; rs35563320; rs11724121; rs4863774; rs35551178; rs13148828; rs35729298; rs6843843; rs7440857; rs34121751; rs35422271; rs36060958; rs33961040; rs34647587; rs34057129; rs4863777; rs33945630; rs5862371; rs6842998; rs7696571; rs35774256; rs28670077; rs35824332; rs34732195; rs4453980; rs1828732; rs10716464; rs34733668; rs34472915; rs7677872; rs34688199; rs10671098; rs35936061; rs35820354; rs33978369; rs6830952; rs35099716; rs35289109; rs35338542; rs11382936; rs34896335; rs35422742; rs1913363; rs34190069; rs41280523; rs6842856; rs10001990; rs7699450; rs34270387; rs6819425; rs13140611; rs36089984; rs35860915; rs13123740; rs13113911; rs10025342; rs34405738; rs4568283; rs7673617; rs34188819; rs4863775; rs35582919; rs28524564; rs5862370; rs34078647; rs35396062; rs5022856; rs34464195; rs35446857; rs13138630; rs34322730; rs35726185; rs35359984; rs5862372; rs4561972; rs41280521; rs35135719; rs36216785; rs11372828; rs34625368; rs4863542; rs10691284; rs34466652; rs7663676; rs35571326; rs34747400; rs35914546; rs7340842; rs7697170; rs5862369; rs36060692; rs28655080; rs36203833; rs10025829; rs34108100; rs34009346; rs5010682; rs4323159; rs35397453; rs35899188; rs34874320; rs1513769; rs34893241; rs35372640; rs34728132; rs35014012; rs35955922; rs33960589; rs34908809; rs35625609; rs28364685; rs11726852; rs13113286; rs34003769; rs35372556; rs4863765; rs4863766; rs6821659; rs6841268; rs7660742; rs7682546

# Macromolecular_Interacting_Partner_1_General_References:
11213471

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8627

# Macromolecular_Interacting_Partner_2_Name:
4F2 cell-surface antigen heavy chain

# Macromolecular_Interacting_Partner_2_Synonyms:
4F2hc; Lymphocyte activation antigen 4F2 large subunit; 4F2 heavy chain antigen; CD98 antigen

# Macromolecular_Interacting_Partner_2_Gene_Name:
SLC3A2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>4F2 cellsurface antigen heavy chain
MSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKF
TGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHT
GALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQID
PNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAG
VDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLT
SSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLP
GTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLS
LFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQAS
DLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYAA

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
529

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
57945

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
4.99

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
Function:  amylase activity
Function:  alpha-amylase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_2_Specific_Function:
Involved in sodium-independent, high-affinity transport of large neutral amino acids. Required for normal and neoplastic cell growth

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00128:Alpha-amylase

# Macromolecular_Interacting_Partner_2_Signals:
1-98

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
82-104

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
182865

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
4F2_HUMAN (P08195)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
SLC3A2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
SLC3A2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:11026

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane; single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1590 bp
ATGAGCCAGGACACCGAGGTGGATATGAAGGAGGTGGAGCTGAATGAGTTAGAGCCCGAG
AAGCAGCCGATGAACGCGGCGTCTGGGGCGGCCATGTCCCTGGCGGGAGCCGAGAAGAAT
GGTCTGGTGAAGATCAAGGTGGCGGAAGACGAGGCGGAGGCGGCAGCCGCGGCTAAGTTC
ACGGGCCTGTCCAAGGAGGAGCTGCTGAAGGTGGCAGGCAGCCCCGGCTGGGTACGCACC
CGCTGGGCACTGCTGCTGCTCTTCTGGCTCGGCTGGCTCGGCATGCTTGCTGGTGCCGTG
GTCATAATCGTGCGAGCGCCGCGTTGTCGCGAGCTACCGGCGCAGAAGTGGTGGCACACG
GGCGCCCTCTACCGCATCGGCGACCTTCAGGCCTTCCAGGGCCACGGCGCGGGCAACCTG
GCGGGTCTGAAGGGGCGTCTCGATTACCTGAGCTCTCTGAAGGTGAAGGGCCTTGTGCTG
GGTCCAATTCACAAGAACCAGAAGGATGATGTCGCTCAGACTGACTTGCTGCAGATCGAC
CCCAATTTTGGCTCCAAGGAAGATTTTGACAGTCTCTTGCAATCGGCTAAAAAAAAGAGC
ATCCGTGTCATTCTGGACCTTACTCCCAACTACCGGGGTGAGAACTCGTGGTTCTCCACT
CAGGTTGACACTGTGGCCACCAAGGTGAAGGATGCTCTGGAGTTTTGGCTGCAAGCTGGC
GTGGATGGGTTCCAGGTTCGGGACATAGAGAATCTGAAGGATGCATCCTCATTCTTGGCT
GAGTGGCAAAATATCACCAAGGGCTTCAGTGAAGACAGGCTCTTGATTGCGGGGACTAAC
TCCTCCGACCTTCAGCAGATCCTGAGCCTACTCGAATCCAACAAAGACTTGCTGTTGACT
AGCTCATACCTGTCTGATTCTGGTTCTACTGGGGAGCATACAAAATCCCTAGTCACACAG
TATTTGAATGCCACTGGCAATCGCTGGTGCAGCTGGAGTTTGTCTCAGGCAAGGCTCCTG
ACTTCCTTCTTGCCGGCTCAACTTCTCCGACTCTACCAGCTGATGCTCTTCACCCTGCCA
GGGACCCCTGTTTTCAGCTACGGGGATGAGATTGGCCTGGATGCAGCTGCCCTTCCTGGA
CAGCCTATGGAGGCTCCAGTCATGCTGTGGGATGAGTCCAGCTTCCCTGACATCCCAGGG
GCTGTAAGTGCCAACATGACTGTGAAGGGCCAGAGTGAAGACCCTGGCTCCCTCCTTTCC
TTGTTCCGGCGGCTGAGTGACCAGCGGAGTAAGGAGCGCTCCCTACTGCATGGGGACTTC
CACGCGTTCTCCGCTGGGCCTGGACTCTTCTCCTATATCCGCCACTGGGACCAGAATGAG
CGTTTTCTGGTAGTGCTTAACTTTGGGGATGTGGGCCTCTCGGCTGGACTGCAGGCCTCC
GACCTGCCTGCCAGCGCCAGCCTCCCAGCCAAGGCTGACCTCCTGCTCAGCACCCAGCCA
GGCCGTGAGGAGGGCTCCCCTCTTGAGCTGGAACGCCTGAAACTGGAGCCTCACGAAGGG
CTGCTGCTCCGCTTCCCCTACGCGGCCTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
J02939

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_2_Locus:
11q13

# Macromolecular_Interacting_Partner_2_SNPs:
rs4726; rs6932; rs489381; rs10897300; rs10897301; rs10792362; rs3809075; rs12221878; rs481235; rs12577251; rs4567465; rs12794763; rs7104190; rs507101; rs7106901; rs12098955; rs561385; rs519473; rs12804553; rs12274689; rs7935096; rs2070870; rs2920155; rs2282477; rs1140538; rs7944051; rs3015957; rs11548759; rs1051342; rs11548756; rs1051289; rs1051290; rs1802910; rs1051237; rs1802911; rs11548760; rs1051285; rs12272749; rs35228448; rs540791; rs549706; rs11231260; rs543622; rs541444; rs34047097; rs35246991; rs1815840; rs3840765; rs11231257; rs544453; rs35881347; rs35320203; rs2957168; rs7130029; rs519425; rs541388; rs34176851; rs535854; rs35091612; rs7106895; rs2096559; rs473815; rs11318751; rs5792273; rs12797676; rs499294; rs34225665; rs3809074; rs2957166; rs7115838; rs12803557; rs521939; rs1938675; rs563394; rs1300138; rs12225962; rs2105515; rs36034735; rs486306; rs12788771; rs1212628; rs1286159; rs5792274; rs12794229; rs7117639; rs495776; rs11231259; rs12366036; rs509327; rs35657900; rs11231261; rs496788; rs35988334; rs12788770; rs34335071; rs1298673; rs766316; rs34722625; rs560603; rs11824602; rs565303; rs34494671; rs35455481; rs7101685; rs1286160; rs510307; rs12270563; rs11231254; rs11231262; rs11318752; rs549635; rs12270604; rs2957167; rs11317361; rs7126772; rs34436839; rs11341257; rs577134; rs11558674; rs1059292; rs11231249; rs11231250; rs12270342; rs12295052; rs1785940; rs2071036; rs2269353; rs2507820; rs2509678; rs2510083; rs3737388; rs3737389; rs4034; rs480730; rs493851; rs498751; rs524891; rs547248; rs560006

# Macromolecular_Interacting_Partner_2_General_References:
3476959; 3036867; 3480538; 3265470; 12754519; 11840567; 12270127

# Macromolecular_Interacting_Partner_2_References:
Not Available

End of HMDB00192

Beginning of HMDB00193
# Accession_No:
HMDB00193

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-17 15:20:16

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Isocitric acid

# Description:
The citrate oxidation to isocitrate is  catalyzed by the enzyme aconitase. Human prostatic secretion is remarkably rich in citric acid and low aconitase activity will therefore play a significant role in enabling accumulation of high citrate levels (PubMed ID 8115279)

# Synonyms:
1-Hydroxy-1,2,3-propanetricarboxylate; 1-Hydroxy-1,2,3-propanetricarboxylic acid; 1-Hydroxypropane-1,2,3-tricarboxylate; 1-Hydroxypropane-1,2,3-tricarboxylic acid; 1-Hydroxytricarballylate; 1-Hydroxytricarballylic acid; 3-Carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylate; 3-Carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid; 3-carboxy-2,3-dideoxy-Pentarate; 3-carboxy-2,3-dideoxy-Pentaric acid; D-isocitrate; I-CIT; isocitrate; threo-Ds-isocitrate; threo-d(s)-iso-citrate

# Chemical_IUPAC_Name:
1-hydroxypropane-1,2,3-tricarboxylic acid

# Chemical_Formula:
C6H8O7

# Chemical_Structure:
tbl_chemical:::HMDB00193_ZOOM.png:::119283244857134819

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00193_THUMB.png:::119283244696064500

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
secondary alcohol; carboxylic acid; alpha-hydroxyacid

# Taxonomy_Biofunction:
Component of Glutathione metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
192.02701

# Molecular_Weight_Avg:
192.12354

# Smiles_String_isomeric:
OC(C(CC(O)=O)C(O)=O)C(O)=O

# Smiles_String_canonical:
OC(C(CC(O)=O)C(O)=O)C(O)=O

# KEGG_Compound_ID:
C00311

# BioCyc_ID:
threo-d(s)-iso-citrate

# PubChem_CID:
1198

# PubChem_SID:
668200; 7990367; 8151021; 8145362; 7990369; 4696413; 452235; 841788; 7990368; 3605; 7990366; 3302

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
34579

# Wikipedia_ID:
Isocitric acid

# METLIN_ID:
3328

# Ref_ID:
813176; 8579834; 8087979; 213213; 595962; 223711; 8389069; 8115279; 7336646; 8412012; 657545

# ChEBI_ID:
16087

# CAS_Registry_Number:
320-77-4

# InChI:
InChI=1/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)

# Synthesis_Reference:
Citric acid biosynthesis by Yarrowia lipolytica A-101-1.31 under deficiency of various medium macrocomponents.     Rywinska, Anita; Wojtatowicz, Maria; Rymowicz, Waldemar.    Department of Biotechnology and Food Microbiology,  Agricultural University of W

# Melting_Point:
162-165 oC

# Melting_Point_predicted:
44.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
466 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
52.5 mg/mL [Predicted by ALOGPS]

# phys_charge:
-3

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-0.34 [Predicted by ALOGPS]; -2.1 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00193_msds.html:::1132562214690784025

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Isocitric_acid.mol:::1132723813140758783

# SDF_File_[Text]:
tbl_chemical:::HMDB00193.sdf:::119283244373253778

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00193.pdb:::11928324455528771

# PDB_ID:
1B0J

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::00193_Isocitric Acid.zip:::118254727358475493

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041201_P08_19_BA_assigned.png:::118254727364181578

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041201_P08_19_BA_2DHSQC_1239.png:::11648421074156186

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041201_P08_19_BA_2DHSQC_1239.zip:::116484210744593148

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::Isocitric acid (HMDB00193).png:::117347424611074650

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Isocitric acid.gif:::1132732120812699850

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00193_peaks.txt:::1156309609420167884

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Isocitric acid_C.gif:::1132737719126719324

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00193_peaks.txt:::1156310798712479249

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00193L.png:::117555266434344147; Medium Energy:tbl_ms:::HMDB00193M.png:::117555270473969983; High Energy:tbl_ms:::HMDB00193H.png:::117555272498587431

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; mitochondria; peroxisome

# Tissue_Location:
Adrenal Gland

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Cellular Cytoplasm; Semen; Urine

# Concentration_[Normal]:
Urine	94.3	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	8087979
Urine	120.1	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	8087979
Urine	53.7	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	45	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	38.9	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	8087979
Urine	19.08 (5.26 - 42.76)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	657545
Blood	6.0 (0.0-10.0)	umol/L	Adult:>18_yrs_old	Both	Normal	8412012
Cerebrospinal_Fluid(CSF)	10.0 +/- 9.0	umol/L	Adult:>18_yrs_old	N/A	Normal	8412012
Semen	400 - 1500	uM	Adult:>18_yrs_old	Both	Normal	8115279
Cellular_Cytoplasm	38 (23-53)	umol/L	Adult:>18_yrs_old	Both	Normal	8579834


# Concentration_[Abnormal]:
Cellular_Cytoplasm	15 (14.8-15.2)	umol/L	Adult:>18_yrs_old	Both	Anoxia	8579834


# Associated_Disorders:
Anoxia; Fetal Hypoxia: Increased

# Pathway_Names:
Glutathione metabolism;Reductive carboxylate cycle (CO2 fixation);Glyoxylate and dicarboxylate metabolism

# Pathway_Images:
;;

# KEGG_Images:
map00480;map00720;map00630

# Pathway_Graphs:
;;

# Pathway_SBMLs:
;;

# Metabolic_Enzyme_1_ID:
6178

# Metabolic_Enzyme_1_Name:
Isocitrate dehydrogenase [NADP], mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
Oxalosuccinate decarboxylase; IDH; NADP(+-specific ICDH; IDP; ICD-M

# Metabolic_Enzyme_1_Gene_Name:
IDH2

# Metabolic_Enzyme_1_Protein_Sequence:
>Isocitrate dehydrogenase NADP, mitochondrial precursor
MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ

# Metabolic_Enzyme_1_Number_of_Residues:
452

# Metabolic_Enzyme_1_Molecular_Weight:
50910

# Metabolic_Enzyme_1_Theoretical_pI:
8.95

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  isocitrate dehydrogenase activity
Function:  isocitrate dehydrogenase (NADP+) activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex

# Metabolic_Enzyme_1_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00480  Glutathione metabolism;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_1_Reaction:
isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00180:Iso_dh

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.1.1.42

# Metabolic_Enzyme_1_GenBank_ID_Protein:
872121

# Metabolic_Enzyme_1_SwissProt_ID:
IDHP_HUMAN (P48735)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
IDH2

# Metabolic_Enzyme_1_Geneatlas_id:
IDH2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:5383

# Metabolic_Enzyme_1_PDB_ID:
1LWD

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_1_Gene_Sequence:
>1359 bp
ATGGCCGGCTACCTGCGGGTCGTGCGCTCGCTCTGCAGAGCCTCAGGCTCGCGGCCGGCC
TGGGCGCCGGCGGCCCTGACAGCCCCCACCTCGCAAGAGCATCCGCGGCGCCACTATGCC
GACAAAAGGATCAAGGTGGCGAAGCCCGTGGTGGAGATGGATGGTGATGAGATGACCCGT
ATTATCTGGCAGTTCATCAAGGAGAAGCTCATCCTGCCCCACGTGGACATCCAGCTAAAG
TATTTTGACCTCGGGCTCCCAAACCGTGACCAGACTGATGACCAGGTCACCATTGACTCT
GCACTGGCCACCCAGAAGTACAGTGTGGCTGTCAAGTGTGCCACCATCACCCCTGATGAG
GCCCGTGTGGAAGAGTTCAAGCTGAAGAAGATGTGGAAAAGTCCCAATGGAACTATCCGG
AACATCCTGGGGGGGACTGTCTTCCGGGAGCCCATCATCTGCAAAAACATCCCACGCCTA
GTCCCTGGCTGGACCAAGCCCATCACCATTGGCAGGCACGCCCATGGCGACCAGTACAAG
GCCACAGACTTTGTGGCAGACCGGGCCGGCACTTTCAAAATGGTCTTCACCCCAAAAGAT
GGCAGTGGTGTCAAGGAGTGGGAAGTGTACAACTTTCCCGCAGGCGGCGTGGGCATGGGC
ATGTACAACACCGACGAGTCCATCTCAGGTTTTGCGCACAGCTGCTTCCAGTATGCCATC
CAGAAGAAATGGCCGCTGTACATGAGCACCAAGAACACCATACTGAAAGCCTACGATGGG
CGTTTCAAGGACATCTTCCAGGAGATCTTTGACAAGCACTATAAGACCGACTTCGACAAG
AATAAGATCTGGTATGAGCACCGGCTCATTGATGACATGGTGGCTCAGGTCCTCAAGTCT
TCGGGTGGCTTTGTGTGGGCCTGCAAGAACTATGACGGAGATGTGCAGTCAGACATCCTG
GCCCAGGGCTTTGGCTCCCTTGGCCTGATGACGTCCGTCCTGGTCTGCCCTGATGGGAAG
ACGATTGAGGCTGAGGCCGCTCATGGGACCGTCACCCGCCACTATCGGGAGCACCAGAAG
GGCCGGCCCACCAGCACCAACCCCATCGCCAGCATCTTTGCCTGGACACGTGGCCTGGAG
CACCGGGGGAAGCTGGATGGGAACCAAGACCTCATCAGGTTTGCCCAGATGCTGGAGAAG
GTGTGCGTGGAGACGGTGGAGAGTGGAGCCATGACCAAGGACCTGGCGGGCTGCATTCAC
GGCCTCAGCAATGTGAAGCTGAACGAGCACTTCCTGAACACCATGGACTTCCTCGACACC
ATCAAGAGCAACCTGGACAGAGCCCTGGGCAGGCAGTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X69433

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_1_Locus:
15q26.1

# Metabolic_Enzyme_1_SNPs:
rs11540478; rs16943901; rs4932279; rs8034938; rs7167577; rs6496622; rs7177165; rs8030346; rs9672249; rs10520685; rs4932278; rs11630814; rs10459702; rs11853055; rs9972549; rs11073899; rs7178604; rs9972327; rs3934860; rs8028234; rs10852126; rs16943899; rs7177558; rs7182369; rs16943894; rs11630335; rs8038011; rs4932280; rs7176347; rs4283211; rs3207044; rs4280211; rs3207045; rs3207047; rs7177032; rs1802920; rs35595609; rs35229668; rs35664386; rs10459675; rs9652516; rs8031694; rs34664136; rs35477556; rs28458925; rs11638845; rs8028270; rs34506900; rs35222274; rs4548834; rs11367383; rs34936041; rs34409906; rs35717725; rs34807593; rs4369633; rs9652515; rs28508560; rs28611491; rs28397672; rs35845864; rs35789470; rs34687144; rs35474233; rs4548833; rs28407278; rs28524104; rs28817699; rs35069981; rs34813967; rs11397045; rs35633367; rs35207526; rs4932157; rs11316815; rs28755429; rs6496621; rs34120525; rs35474715; rs28664905; rs12912761; rs34116091; rs36118949; rs4462566; rs28795173; rs34281036; rs10622800; rs28592803; rs4516205; rs4537990; rs34405020; rs34552862; rs4932281; rs2970355; rs5814411; rs35833570; rs28547012; rs11298094; rs28692845; rs4539574; rs4341718; rs3207049; rs1142630; rs13380100; rs1064031; rs28727276; rs34123931; rs17523637; rs3207046; rs3207050; rs4932277; rs35788632; rs4570818; rs8026919; rs5020666; rs28489267; rs4316732; rs11545493; rs3207048; rs34380663; rs11073900; rs11632348; rs12443387; rs2939846; rs2939847; rs2939850; rs2970356; rs2970357; rs2970358; rs2970359; rs4553601; rs4561444; rs4577063; rs6496620; rs7168705

# Metabolic_Enzyme_1_General_References:
Not Available

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6179

# Metabolic_Enzyme_2_Name:
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial precursor

# Metabolic_Enzyme_2_Synonyms:
Isocitric dehydrogenase; NAD(+-specific ICDH

# Metabolic_Enzyme_2_Gene_Name:
IDH3B

# Metabolic_Enzyme_2_Protein_Sequence:
>Isocitrate dehydrogenase NAD subunit beta, mitochondrial precursor
MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHAASRSQAEDVRVEGSFPVTMLPGDGVG
PELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPME
YKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESAR
GVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELY
PKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY
AVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRT
RDMGGYSTTTDFIKSVIGHLQTKGS

# Metabolic_Enzyme_2_Number_of_Residues:
385

# Metabolic_Enzyme_2_Molecular_Weight:
42184

# Metabolic_Enzyme_2_Theoretical_pI:
8.66

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  isocitrate dehydrogenase activity
Function:  isocitrate dehydrogenase (NAD+) activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  mitochondrion

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH

# Metabolic_Enzyme_2_Pathway:
map00020  Citrate cycle (TCA cycle)

# Metabolic_Enzyme_2_Reaction:
isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00180:Iso_dh

# Metabolic_Enzyme_2_Signals:
1-25

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.1.41

# Metabolic_Enzyme_2_GenBank_ID_Protein:
2737886

# Metabolic_Enzyme_2_SwissProt_ID:
IDH3B_HUMAN (O43837)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
IDH3B

# Metabolic_Enzyme_2_Geneatlas_id:
IDH3B

# Metabolic_Enzyme_2_hgnc_id:
HGNC:5385

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_2_Gene_Sequence:
>1158 bp
ATGGCGGTATTGAGCGGAGTCCGCTGGCTGACCCGAGCGCTGGTCTCCGCCGGGAACCCT
GGGGCATGGAGAGGTCTGAGTACCTCGGCCGCGGCGCACGCTGCATCGCGGAGCCAGGCC
GAGGACGTGAGGGTGGAGGGCTCCTTTCCCGTGACCATGCTTCCGGGAGACGGTGTGGGG
CCTGAGCTGATGCACGCCGTCAAGGAGGTGTTCAAGGCTGCCGCTGTCCCAGTGGAGTTC
CAGGAGCACCACCTGAGTGAGGTGCAGAATATGGCATCTGAGGAGAAGCTGGAGCAGGTG
CTGAGTTCCATGAAGGAGAACAAAGTGGCCATCATTGGAAAGATTCATACCCCGATGGAG
TATAAGGGGGAGCTAGCCTCCTATGATATGCGGCTGAGGCGTAAGTTGGACTTATTTGCC
AACGTAGTCCATGTGAAGTCACTTCCTGGGTATATGACTCGGCACAACAATCTAGACCTG
GTGATCATTCGAGAGCAGACAGAAGGGGAGTACAGCTCTCTGGAACATGAGAGTGCAAGG
GGTGTGATTGAGTGTTTGAAGATTGTCACACGAGCCAAGTCTCAGCGGATTGCAAAGTTC
GCCTTTGACTATGCCACCAAGAAGGGGCGGGGCAAGGTCACTGCTGTCCACAAGGCCAAC
ATCATGAAACTTGGGGATGGGTTGTTCCTGCAGTGCTGTGAGGAAGTTGCTGAACTGTAC
CCCAAAATCAAATTTGAGACAATGATCATAGACAACTGCTGCATGCAGCTGGTGCAGAAT
CCTTACCAGTTTGATGTGCTTGTGATGCCCAATCTCTATGGGAACATTATTGACAATCTG
GCTGCTGGCCTGGTTGGGGGAGCTGGTGTGGTCCCTGGTGAGAGCTATAGTGCAGAATAC
GCAGTCTTTGAGACGGGTGCCCGGCACCCATTTGCCCAGGCAGTGGGCAGGAATATAGCC
AATCCCACGGCCATGCTGCTGTCGGCTTCCAACATGCTGCGGCATCTTAATCTTGAGTAT
CACTCCAGCATGATCGCAGATGCGGTGAAGAAGGTGATCAAAGTTGGCAAGGTGCGGACT
CGAGACATGGGCGGCTACAGCACCACAACCGACTTCATCAAGTCTGTCATCGGTCACCTG
CAGACTAAAGGGAGCTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
U49283

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_2_Locus:
20p13

# Metabolic_Enzyme_2_SNPs:
rs6107100; rs6037269; rs2073193; rs6115381; rs6083982; rs2235955; rs5026920; rs6037255; rs2325899; rs2235954; rs6132899; rs6138735; rs2422822; rs2422823; rs2073197; rs2073192; rs3178817; rs11542741; rs6083985; rs35977428; rs35770898; rs11473919; rs11472473; rs11476625; rs6050986; rs11475857; rs34057313; rs35543437; rs6083987; rs3180298; rs7352251; rs41275514; rs6115368; rs35470138; rs7354497; rs35267151; rs11475797; rs34167940; rs7260969; rs6138742; rs11907376; rs11313071; rs6051019; rs8116107; rs11480596; rs11480597; rs11699466; rs16987867; rs1883977; rs2273137; rs2422821; rs2422824; rs34450120; rs6050898; rs6051076; rs6083954; rs6107120; rs6115439; rs6132905; rs7260755; rs742843; rs8125340

# Metabolic_Enzyme_2_General_References:
11780052

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
6000

# Metabolic_Enzyme_3_Name:
Aconitate hydratase, mitochondrial precursor

# Metabolic_Enzyme_3_Synonyms:
Citrate hydro-lyase; Aconitase

# Metabolic_Enzyme_3_Gene_Name:
ACO2

# Metabolic_Enzyme_3_Protein_Sequence:
>Aconitate hydratase, mitochondrial precursor
MAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRLN
RPLTLSEKIV
YGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVA
VPSTIHCDHLIEAQVGGEKDL
RRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIIL
ENYAYPGVLLIGTDSHTPNGGGLGGICIGVGG
ADAVDVMAGIPWELKCPKVIGVKLTGS
LSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGM
ATICNMGAEIGATTSV
FPYNHRMKKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHIN
GPFTP
DLAHPVAEVGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFT
ITPGS
EQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNR
NFTGRNDANPETHAFV
TSPEIVTALAIAGTLKFNPETDYLTGTDGKKFRLEAPDADELP
KGEFDPGQDTYQHPPKDSSGQHVDVSP
TSQRLQLLEPFDKWDGKDLEDLQILIKVKGKC
TTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKAN
SVRNAVTQEFGPVPDTARYYK
KHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLK
KQGLLPLTFA
DPADYNKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGS

ALNRMKELQQ

# Metabolic_Enzyme_3_Number_of_Residues:
780

# Metabolic_Enzyme_3_Molecular_Weight:
85426

# Metabolic_Enzyme_3_Theoretical_pI:
7.65

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  aconitate hydratase activity
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-oxygen lyase activity
Function:  hydro-lyase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
 ||
>>>
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  mitochondrion

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
Citrate = cis-aconitate + H(2)O

# Metabolic_Enzyme_3_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00630  Glyoxylate and dicarboxylate metabolism;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_3_Reaction:
citrate = cis-aconitate + H2O

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00330:Aconitase;
PF00694:Aconitase_C

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 4.2.1.3

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1718502

# Metabolic_Enzyme_3_SwissProt_ID:
ACON_HUMAN (Q99798)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ACO2

# Metabolic_Enzyme_3_Geneatlas_id:
ACO2

# Metabolic_Enzyme_3_hgnc_id:
HGNC:118

# Metabolic_Enzyme_3_PDB_ID:
1B0J

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_3_Gene_Sequence:
>2343 bp

ATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTA
CCATGTGGCCT
CAGTCCTGTGCCAACGGGCCAAGGTGGCGATGACGCATTTTGAGCCCA
ACGAGTACATCCATTATGACCT
GCTAGAGAAGAACATTAACATTGTTCGCAAACGACTG
AACCGGCCGCTGACACTCTCGGAGAAGATTGTG
TATGGACACCTGGATGACCCCGCCAG
CCAGGAAATTGAGCGAGGCAAGTCGTACCTGCGGCTGCGGCCCG
ACCGTGTGGCCATGC
AGGATGCGACGGCCCAGATGGCCATGCTCCAGTTCATCAGCAGCGGGCTGTCCAA
GGTG
GCTGTGCCATCCACCATCCACTGTGACCATCTGATTGAAGCCCAGGTTGGGGACGAGAAA
GACCTG
CGCCGGGCCAAGGACATCAACCAGGAAGTTTATAATTTCCTGGCAACTGCAGG
TGACAAGTATGGCGTGG
GCTTCTGGAGCCCTGGATCTGGAATCATTCACCAGATTATTC
TCGAAAACTATGCGTACCCTGGAGTTCT
TCTGATTGGAACTGACTCCCACACCCCCAAT
GGTGGTGGCCTAGGAGGCATCTGCATTGGAGTAGGGGGT
GCAGATGCTGTGGATGTCAT
GGCTGGGATCCCCTGGGAGCTGAAGTGCCCCAAGGTGATTGGCGTGAAGC
TGACGGGCT
CTCTCTCCGGTTGGACCTCACCCAAAGATGTGATCCTGAAGGTGGCAGGCATCCTCACGG
T
GAAAGGTGGCACAGGTGCAATCGTGGAATACCACGGGCCTGGTGTAGACTCCATGTCC
TGCACTGGCATG
GCGACAATCTGCAACATGGGTGCAGAAATTGGGGCCACCACTTCCGT
GTTCCCTTACAACCACAGGATGA
AGAAGTACCTGAGCAAGACCGGCCGGGAAGACATTG
CCAATCTAGCTGATGAATTCAAGGATCACTTGGT
GCCTGACCCTGGCTGCCATTATGAC
CAACTAATTGAAATTAACCTCAGTGAGCTGAAGCCACACATCAAT
GGGCCCTTCACCCC
TGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAGAAGGAAGGATGGC
CTC
TGGACATCCGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGC
GCTCAGC
AGCTGTGGCCAAGCAGGCACTGGCCCATGGACTCAAGTGCAAGTCCCAGTTC
ACCATCACTCCAGGTTCC
GAGCAGATCCGCGCCACCATTGAGCGGGACGGCTATGCACA
GATCCTGAGGGATCTGGGTGGCATTGTCC
TGGCCAATGCCTGCGGGCCCTGCATTGGCC
AGTGGGACAGAAAGGACATCAAGAAGGGGGAGAAGAACAC
AATCGTCACCTCCTACAAC
AGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTTGTC
ACGTCCCC
AGAGATTGTCACAGCCCTGGCCATTGCAGGAACCCTCAAGTTCAACCCAGAGACCGACTA
CC
TGACAGGCAAGGATGGCAAGAAGTTCAGGCTGGAAGCTCCGGATGCAGATGAGCTTC
CCAAAGGGGAGTT
TGACCCAGGGCAGGACACCTACCAGCACCCCCCAAAGGACAGCAGC
AGGCAGCATGTGGACGTGAGCCCC
ACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGA
CAAGTGGGATGGCAAGGACCTGGAGGACCTGCAGA
TCCTCATCAAGGTCAAAGGGAAGT
GTACCACTGACCACATCTCAGCTGCTGGCCCCTGGCTCAAGTTCCG
TGGGCACTTGGAT
AACATCTCCAACAACCTGCTCATTGGTGCCATCAACATTGAAAACGGCAAGGCCAAC
TC
CGTGCGCAATGCCGTCACTCAGGAGTTTGGCCCCGTCCCTGACACTGCCCGCTACTACAA
GAAACATG
GCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCGAGCC
GGGAGCATGCAGCTCTGGA
GCCTCGCCACCTTGGGGGCCGGGCCATCATCACCAAGAGC
TTTGCCAGGATCCACGAGACCAACCTGAAG
AAACAGGGCCTGCTGCCTCTGACCTTCGC
TGACCCGGCTGACTACAACAAGATTCACCCTGTGGACAAGC
TGACCATTCAGGGCCTGA
AGGACTTCACCCCTGGCAAGCCCCTGAAGTGCATCATCAAGCACCCCAACGG
GACCCAG
GAGACCATCCTCCTGAACCACACCTTCAACGAGACGCAGATTGAGTGGTTCCGCGCTGGC
AGT
GCCCTCAACAGAATGAAGGAACTGCAACAGTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U80040

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_3_Locus:
22q11.2-q13.31|22q13.2-q13.31

# Metabolic_Enzyme_3_SNPs:
rs137831; rs1799932; rs203320; rs169361; rs2284080; rs1960182; rs6519256; rs6519257; rs203319; rs12167184; rs5751114; rs12484694; rs2267434; rs2076196; rs12165815; rs6002390; rs2267433; rs5751117; rs9619974; rs9623409; rs79013; rs2267432; rs9611602; rs3827359; rs9623412; rs2413647; rs2267435; rs79011; rs9623411; rs2413645; rs2076199; rs727563; rs6002392; rs203318; rs11090049; rs11705190; rs3045391; rs7290434; rs738140; rs2284081; rs17002483; rs203317; rs8136366; rs1569516; rs17367716; rs7288661; rs9611603; rs7289999; rs202612; rs202610; rs11912852; rs2413646; rs9611604; rs17002487; rs7290508; rs137830; rs5758375; rs2267436; rs12170066; rs9607809; rs9611598; rs5758380; rs2006715; rs11554470; rs17856753; rs1049860; rs1049856; rs17852363; rs1049859; rs11554469; rs1049852; rs1049857; rs17852364; rs5758376; rs28634007; rs9611599; rs13054766; rs5751116; rs35732387; rs36024770; rs8185004; rs6002398; rs5758373; rs3838162; rs760810; rs5751115; rs34344341; rs9607807; rs5996034; rs34289556; rs137832; rs35052987; rs11331024; rs5845502; rs10639444; rs34646526; rs5758374; rs5758372; rs34309135; rs9680659; rs12166976; rs34770725; rs28407070; rs13056499; rs6002396; rs5751113; rs5758371; rs9607808; rs33914175; rs34337889; rs9623407; rs35192350; rs9607810; rs8141415; rs34893746; rs36062011; rs35664977; rs5758379; rs41281289; rs11372053; rs9680658; rs13342919; rs12628178; rs8139104; rs8141184; rs5758370; rs34610631; rs34433589; rs5845503; rs35435675; rs33969654; rs7287931; rs203321; rs9611605; rs9680628; rs34571918; rs34563140; rs5758377; rs35902787; rs9680631; rs34759958; rs7286459; rs41276321; rs9623410; rs34487526; rs9680629; rs2102246; rs137829; rs35270250; rs9623408; rs34742939; rs11705367; rs202609; rs9680630; rs34491448; rs9680654; rs35849502; rs35948127; rs4510317; rs8184972; rs28620979; rs34342736; rs28488294; rs35891403; rs5845504; rs35087813; rs3045393; rs34527134; rs34805234; rs34957102; rs1042972; rs10483211; rs12160340; rs12168565; rs17367849; rs1810460; rs1810461; rs188058; rs19573; rs2008065; rs202631; rs203313; rs203315; rs203316; rs2076197; rs2076198; rs2267430; rs2267431; rs34057431; rs34340787; rs35463585; rs4822032; rs4822034; rs505533; rs5751108; rs5758365; rs5758368; rs5758381; rs5758384; rs79009; rs9611597; rs9611606

# Metabolic_Enzyme_3_General_References:
9630632; 10591208

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
6180

# Metabolic_Enzyme_4_Name:
Isocitrate dehydrogenase [NADP] cytoplasmic

# Metabolic_Enzyme_4_Synonyms:
Cytosolic NADP-isocitrate dehydrogenase; Oxalosuccinate decarboxylase; IDH; NADP(+-specific ICDH; IDP

# Metabolic_Enzyme_4_Gene_Name:
IDH1

# Metabolic_Enzyme_4_Protein_Sequence:
>Isocitrate dehydrogenase NADP cytoplasmic
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL

# Metabolic_Enzyme_4_Number_of_Residues:
414

# Metabolic_Enzyme_4_Molecular_Weight:
46660

# Metabolic_Enzyme_4_Theoretical_pI:
7.00

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  isocitrate dehydrogenase activity
Function:  isocitrate dehydrogenase (NADP+) activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH

# Metabolic_Enzyme_4_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00480  Glutathione metabolism;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_4_Reaction:
isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00180:Iso_dh

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.1.1.42

# Metabolic_Enzyme_4_GenBank_ID_Protein:
3641398

# Metabolic_Enzyme_4_SwissProt_ID:
IDHC_HUMAN (O75874)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
IDH1

# Metabolic_Enzyme_4_Geneatlas_id:
IDH1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:5382

# Metabolic_Enzyme_4_PDB_ID:
1T0L

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasm. Peroxisome

# Metabolic_Enzyme_4_Gene_Sequence:
>1245 bp
ATGTCCAAAAAAATCAGTGGCGGTTCTGTGGTAGAGATGCAAGGAGATGAAATGACACGA
ATCATTTGGGAATTGATTAAAGAGAAACTCATTTTTCCCTACGTGGAATTGGATCTACAT
AGCTATGATTTAGGCATAGAGAATCGTGATGCCACCAACGACCAAGTCACCAAGGATGCT
GCAGAAGCTATAAAGAAGCATAATGTTGGCGTCAAATGTGCCACTATCACTCCTGATGAG
AAGAGGGTTGAGGAGTTCAAGTTGAAACAAATGTGGAAATCACCAAATGGCACCATACGA
AATATTCTGGGTGGCACGGTCTTCAGAGAAGCCATTATCTGCAAAAATATCCCCCGGCTT
GTGAGTGGATGGGTAAAACCTATCATCATAGGTCGTCATGCTTATGGGGATCAATACAGA
GCAACTGATTTTGTTGTTCCTGGGCCTGGAAAAGTAGAGATAACCTACACACCAAGTGAC
GGAACCCAAAAGGTGACATACCTGGTACATAACTTTGAAGAAGGTGGTGGTGTTGCCATG
GGGATGTATAATCAAGATAAGTCAATTGAAGATTTTGCACACAGTTCCTTCCAGATGGCT
CTGTCTAAGGGTTGGCCTTTGTATCTGAGCACCAAAAACACTATTCTGAAGATATATGAT
GGGCGTTTTAAAGACATCTTTCAGGAGATATATGACAAGCAGTACAAGTCCCAGTTTGAA
GCTCAAAAGATCTGGTATGAGCATAGGCTCATCGACGACATGGTGGCCCAAGCTATGAAA
TCAGAGGGAGGCTTCATCTGGGCCTGTAAAAACTATGATGGTGACGTGCAGTCGGACTCT
GTGGCCCAAGGGTATGGCTCTCTCGGCATGATGACCAGCGTGCTGGTTTGTCCAGATGGC
AAGACAGTAGAAGCAGAGGCTGCCCACGGGACTGTAACCCGTCACTACCGCATGTACCAG
AAAGGACAGGAGACGTCCACCAACCTCATTGCTTCCATTTTTGCCTGGACCAGAGGGTTA
GCCCACAGAGCAAAGCTTGATAACAATAAAGAGCTTGCCTTCTTTGCAAATGCTTTGGAA
GAAGTCTCTATTGAGACAATTGAGGCTGGCTTCATGACCAAGGACTTGGCTGCTTGCATT
AGAGGTTTACCCAATGTGCAACGTTCTGACTACTTGAATACATTTGAGTTCATGGATAAA
CTTGGAGAAAACTTGAAGATCAAACTAGCTCAGGCCAAACTTTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF020038

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_4_Locus:
2q33.3

# Metabolic_Enzyme_4_SNPs:
rs34218846; rs1437410; rs1023751; rs6730955; rs966730; rs3769521; rs1044416; rs13026; rs12612631; rs7565247; rs16840798; rs9646837; rs11900211; rs6725277; rs1446323; rs16840789; rs10202116; rs6435435; rs1446324; rs10170549; rs3928183; rs16840793; rs11685614; rs16840794; rs16840803; rs9646838; rs13395413; rs10207062; rs7593466; rs16840781; rs12478635; rs11888463; rs12694100; rs1446325; rs10174866; rs16840769; rs13421557; rs12105636; rs28384385; rs34599179; rs11554138; rs3778; rs11554137; rs35585619; rs3769522; rs16841606; rs15343; rs11554139; rs11554136; rs34777764; rs15344; rs12621845; rs35374815; rs35940089; rs34082542; rs11433971; rs11370808; rs35384132; rs17652540; rs34825295; rs28522161; rs11305109; rs7558080; rs34567563; rs7609093; rs3841868; rs5838113; rs16840791; rs5023936; rs28658028; rs1446322; rs28635503; rs4608458; rs34487895; rs35420069; rs34363027; rs10606767; rs34879428; rs13387817; rs5023935; rs16840801; rs11370730; rs1061944; rs1982335; rs4505462; rs36102436; rs10194538; rs2166450; rs10201808; rs11883490; rs13000809; rs13021406; rs13021560; rs13385588; rs13392540; rs1992739; rs1992740; rs4290589; rs6719638; rs6724106; rs6734788; rs7578542; rs7592544; rs7593482; rs9288391

# Metabolic_Enzyme_4_General_References:
9866202; 10521434; 11230166

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
6181

# Metabolic_Enzyme_5_Name:
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
Isocitric dehydrogenase; NAD(+-specific ICDH

# Metabolic_Enzyme_5_Gene_Name:
IDH3A

# Metabolic_Enzyme_5_Protein_Sequence:
>Isocitrate dehydrogenase NAD subunit alpha, mitochondrial precursor
MAGPAWISKVSRLLGAFHNPKQVTRGFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKAP
IQWEERNVTAIQGPGGKWMIPSEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDL
YANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIA
EFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMV
QDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKD
MANPTALLLSAVMMLRHMGLFDHAARIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICR
RVKDLD

# Metabolic_Enzyme_5_Number_of_Residues:
366

# Metabolic_Enzyme_5_Molecular_Weight:
39592

# Metabolic_Enzyme_5_Theoretical_pI:
6.93

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  isocitrate dehydrogenase activity
Function:  isocitrate dehydrogenase (NAD+) activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  mitochondrion

# Metabolic_Enzyme_5_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_5_Specific_Function:
Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH

# Metabolic_Enzyme_5_Pathway:
map00020  Citrate cycle (TCA cycle)

# Metabolic_Enzyme_5_Reaction:
isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00180:Iso_dh

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.1.1.41

# Metabolic_Enzyme_5_GenBank_ID_Protein:
706839

# Metabolic_Enzyme_5_SwissProt_ID:
IDH3A_HUMAN (P50213)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
IDH3A

# Metabolic_Enzyme_5_Geneatlas_id:
IDH3A

# Metabolic_Enzyme_5_hgnc_id:
HGNC:5384

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_5_Gene_Sequence:
>1101 bp
ATGGCTGGGCCCGCGTGGATCTCCAAGGTCTCTCGGCTGCTGGGGGCATTCCACAACCCA
AAACAGGTGACCAGAGGTTTTACTGGTGGTGTTCAGACAGTAACTTTAATTCCAGGAGAT
GGTATTGGCCCAGAAATTTCAGCTGCAGTTATGAAGATTTTTGATGCTGCCAAAGCACCT
ATTCAGTGGGAGGAGCGGAACGTCACTGCCATTCAAGGACCTGGAGGAAAGTGGATGATC
CCTTCAGAGGCTAAAGAGTCCATGGATAAGAACAAGATGGGCTTGAAAGGCCCTTTGAAG
ACCCCAATAGCAGCCGGTCACCCATCTATGAATTTACTGCTGCGCAAAACATTTGACCTT
TACGCGAATGTCCGACCATGTGTCTCTATCGAAGGCTATAAAACCCCTTACACCGATGTA
AATATTGTGACCATTCGAGAGAACACAGAAGGAGAATACAGTGGAATTGAGCATGTGATT
GTTGATGGAGTCGTGCAGAGTATCAAGCTCATCACCGAGGGGGCGAGCAAGCGCATTGCT
GAGTTTGCCTTTGAGTATGCCCGGAACAACCACCGGAGCAACGTCACGGCGGTGCACAAA
GCCAACATCATGCGGATGTCAGATGGGCTTTTTCTACAAAAATGCAGGGAAGTTGCAGAA
AGCTGTAAAGATATTAAATTTAATGAGATGTACCTTGATACAGTATGTTTGAATATGGTA
CAAGATCCTTCCCAATTTGATGTTCTTGTTATGCCAAATTTGTATGGAGACATCCTTAGT
GACTTGTGTGCAGGATTGATCGGAGGTCTCGGTGTGACACCAAGTGGCAACATTGGAGCC
AATGGGGTTGCAATTTTTGAGTCGGTTCATGGGACGGCTCCAGACATTGCAGGCAAGGAC
ATGGCGAATCCCACAGCCCTCCTGCTCAGTGCCGTGATGATGCTGCGCCACATGGGACTT
TTTGACCATGCTGCAAGAATTGAGGCTGCGTGTTTTGCTACAATTAAGGACGGAAAGAGC
TTGACAAAAGATTTGGGAGGCAATGCAAAATGCTCAGACTTCACAGAGGAAATCTGTCGC
CGAGTAAAAGATTTAGATTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U07681

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_5_Locus:
15q25.1-q25.2

# Metabolic_Enzyme_5_SNPs:
rs12442361; rs2304826; rs17674205; rs3087998; rs7180781; rs3816253; rs2304825; rs4570804; rs8032618; rs11855354; rs11630776; rs7180687; rs11631100; rs2868607; rs4243076; rs2044098; rs12439733; rs12438666; rs7165190; rs1982242; rs11638921; rs4886560; rs13329259; rs12441406; rs6495276; rs1982241; rs35290953; rs11631060; rs11072733; rs28425556; rs28616259; rs28658241; rs12904700; rs12912695; rs11454139; rs11431104; rs36097798; rs3053091; rs34495427; rs11392698; rs35778714; rs12904688; rs5813901; rs35155096; rs28696266; rs7178474; rs36026458; rs3217502; rs28378963; rs33914139; rs12904404; rs2868611; rs8027582; rs5813902; rs13329641; rs28521691; rs12906189; rs35284793; rs35224810; rs34573203; rs2044097; rs34420032; rs35150451; rs12911159; rs35197181; rs2868610; rs12050483; rs10654390; rs34639855; rs35356502; rs2868608; rs28588665; rs28544503; rs11394499; rs3972619; rs4392025; rs34031476; rs28722828; rs11319259; rs3816254; rs36117315; rs35658423; rs34684932; rs11854120; rs3825848; rs4435231; rs4887010; rs35964398; rs35451119; rs12904639; rs35694237; rs35017966; rs1049436; rs11072732; rs11072735; rs11072736; rs11629561; rs11630013; rs11631653; rs11635268; rs11638547; rs12903696; rs12910386; rs12911405; rs12915990; rs16969548; rs17479031; rs17850483; rs17850484; rs2028548; rs2304824; rs2868606; rs34921279; rs3743081; rs3825847; rs7165154; rs7179651; rs8026337; rs8034946; rs8035724; rs9920103

# Metabolic_Enzyme_5_General_References:
7755589

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
6001

# Metabolic_Enzyme_6_Name:
Iron-responsive element-binding protein 1

# Metabolic_Enzyme_6_Synonyms:
IRE-BP 1; Iron regulatory protein 1; IRP1; Ferritin repressor protein; Aconitate hydratase; Citrate hydro-lyase; Aconitase

# Metabolic_Enzyme_6_Gene_Name:
ACO1

# Metabolic_Enzyme_6_Protein_Sequence:
>Ironresponsive elementbinding protein 1
MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDI
ENILHWNVTQ
HKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCP
ADLVIDHSIQVDFNRRADSLQ
KNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIH
QVNLEYLARVVFDQDGYYYPDSLVGTDSHTTM
IDGLGILGWGVGGIEAEAVMLGQPISM
VLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEF
FGPGVAQLSIADRATI
ANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPS
QDPDF
TQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTF
IYDNT
EFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPG
SGVVTYYLQESGVMPY
LSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLS
GNRNFEGRVHPNTRANYLASPPLVIAY
AIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPT
RDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPS
DKLFFWNSKSTYIKSPPFFEN
LTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRG
LTPREFNSYG
SRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLA

GKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGL
TGQERYTIIIP
ENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMA
K

# Metabolic_Enzyme_6_Number_of_Residues:
889

# Metabolic_Enzyme_6_Molecular_Weight:
98400

# Metabolic_Enzyme_6_Theoretical_pI:
6.66

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  aconitate hydratase activity
Function:  nucleic acid binding
Function:  RNA binding
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-oxygen lyase activity
Function:  hydro-lyase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_6_Specific_Function:
This protein also expresses aconitase activity

# Metabolic_Enzyme_6_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00630  Glyoxylate and dicarboxylate metabolism;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_6_Reaction:
citrate = cis-aconitate + H2O

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00330:Aconitase;
PF00694:Aconitase_C

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 4.2.1.3

# Metabolic_Enzyme_6_GenBank_ID_Protein:
33963

# Metabolic_Enzyme_6_SwissProt_ID:
IREB1_HUMAN (P21399)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ACO1

# Metabolic_Enzyme_6_Geneatlas_id:
ACO1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:117

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_6_Gene_Sequence:
>2670 bp

ATGAGCAACCCATTCGCACACCTTGCTGAGCCATTGGATCCTGTACAACCAGGAAAGAA
ATTCTTCAATT
TGAATAAATTGGAGGATTCAAGATATGGGCGCTTACCATTTTCGATCA
GAGTTCTTCTGGAAGCAGCCAT
TCGGAATTGTGATGAGTTTTTGGTGAAGAAACAGGAT
ATTGAAAATATTCTACATTGGAATGTCACTCAG
CACAAGAACATAGAAGTGCCATTTAA
GCCTGCTCGTGTCATCCTGCAGGACTTTACGGGTGTGCCCGCTG
TGGTTGACTTTGCTG
CAATGCGTGATGCTGTGAAAAAGTTAGGAGGAGATCCAGAGAAAATAAACCCTGT
CTGC
CCTGCTGATCTTGTAATAGATCATTCCATCCAGGTTGATTTCAACAGAAGGGCAGACAGT
TTACAG
AAGAATCAAGACCTGGAATTTGAAAGAAATAGAGAGCGATTTGAATTTTTAAA
GTGGGGTTCCCAGGCTT
TTCACAACATGCGGATTATTCCCCCTGGCTCAGGAATCATCC
ACCAGGTGAATTTGGAATATTTGGCAAG
AGTGGTATTTGATCAGGATGGATATTATTAC
CCAGACAGCCTCGTGGGCACAGACTCGCACACTACCATG
ATTGATGGCTTGGGCATTCT
TGGTTGGGGTGTCGGTGGTATTGAAGCAGAAGCTGTCATGCTGGGTCAGC
CAATCAGTA
TGGTGCTTCCTCAGGTGATTGGCTACAGGCTGATGGGGAAGCCCCACCCTCTGGTAACAT
C
CACTGACATCGTGCTCACCATTACCAAGCACCTCCGCCAGGTTGGGGTAGTGGGCAAA
TTTGTCGAGTTC
TTCGGGCCTGGAGTAGCCCAGTTGTCCATTGCTGACCGAGCTACGAT
TGCTAACATGTGTCCAGAGTACG
GAGCAACTGCTGCCTTTTTCCCAGTTGATGAAGTTA
GTATCACGTACCTGGTGCAAACAGGTCGTGATGA
AGAAAAATTAAAGTATATTAAAAAA
TATCTTCAGGCTGTAGGAATGTTTCGAGATTTCAATGACCCTTCT
CAAGACCCAGACTT
CACCCAGGTTGTGGAATTAGATTTGAAAACAGTAGTGCCTTGCTGTAGTGGACCCA
AAA
GGCCTCAGGACAAAGTTGCTGTGTCCGACATGAAAAAGGACTTTGAGAGCTGCCTTGGAG
CCAAGCA
AGGATTTAAAGGATTCCAAGTTGCTCCTGAACATCATAATGACCATAAGACC
TTTATCTATGATAACACT
GAATTCACCCTTGCTCATGGTTCTGTGGTCATTGCTGCCAT
TACTAGCTGCACAAACACCAGTAATCCGT
CTGTGATGTTAGGGGCAGGATTGTTAGCAA
AGAAAGCTGTGGATGCTGGCCTGAACGTGATGCCTTACAT
CAAAACTAGCCTGTCTCCT
GGGAGTGGCGTGGTCACCTACTACCTACAAGAAAGCGGAGTCATGCCTTAT
CTGTCTCA
GCTTGGGTTTGACGTGGTGGGCTATGGCTGCATGACCTGCATTGGCAACAGTGGGCCTTT
AC
CTGAACCTGTGGTAGAAGCCATCACACAGGGAGACCTTGTAGCTGTTGGAGTACTAT
CTGGAAACAGGAA
TTTTGAAGGTCGAGTTCACCCCAACACCCGGGCCAACTATTTAGCC
TCTCCCCCCTTAGTAATAGCATAT
GCAATTGCTGGAACCATCAGAATCGACTTTGAGAA
AGAGCCATTGGGAGTAAATGCAAAGGGACAGCAGG
TATTTCTGAAAGATATCTGGCCGA
CTAGAGACGAGATCCAGGCAGTGGAGCGTCAGTATGTCATCCCGGG
GATGTTTAAGGAA
GTCTATCAGAAAATAGAGACTGTGAATGAAAGCTGGAATGCCTTAGCAACCCCATCA
GA
TAAGCTGTTTTTCTGGAATTCCAAATCTACGTATATCAAATCACCACCATTCTTTGAAAA
CCTGACTT
TGGATCTTCAGCCCCCTAAATCTATAGTGGATGCCTATGTGCTGCTAAATT
TGGGAGATTCGGTAACAAC
TGACCACATCTCCCCAGCTGGAAATATTGCAAGAAACAGT
CCTGCTGCTCGCTACTTAACTAACAGAGGC
CTAACTCCACGAGAATTCAACTCCTATGG
CTCCCGCCGAGGTAATGACGCCGTCATGGCACGGGGAACAT
TTGCCAACATTCGCTTGT
TAAACAGATTTTTGAACAAGCAGGCACCACAGACTATCCATCTGCCTTCTGG
GGAAATC
CTTGATGTGTTTGATGCTGCTGAGCGGTACCAGCAGGCAGGCCTTCCCCTGATCGTTCTG
GCT
GGCAAAGAGTACGGTGCAGGCAGCTCCCGAGACTGGGCAGCTAAGGGCCCTTTCCT
GCTGGGAATCAAAG
CCGTCCTGGCCGAGAGCTACGAGCGCATTCACCGCAGTAACCTGG
TTGGGATGGGTGTGATCCCACTTGA
ATATCTCCCTGGTGAGAATGCAGATGCCCTGGGG
CTCACAGGGCAAGAACGATACACTATCATTATTCCA
GAAAACCTCAAACCACAAATGAA
AGTCCAGGTCAAGCTGGATACTGGCAAGACCTTCCAGGCTGTCATGA
GGTTTGACACTG
ATGTGGAGCTCACTTATTTCCTCAACGGGGGCATCCTCAACTACATGATCCGCAAGAT
G
GCCAAGTAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
Z11559

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_6_Locus:
9p22-q32|9p22-p13

# Metabolic_Enzyme_6_SNPs:
rs34630459; rs3780473; rs34319839; rs35370505; rs1041321; rs4495514; rs7028085; rs882812; rs1028932; rs7033149; rs6476361; rs5005316; rs7028748; rs913762; rs10813809; rs10813808; rs1041320; rs12985; rs10970952; rs10738885; rs7847742; rs10970961; rs10813810; rs7873764; rs10813805; rs7866419; rs4297112; rs1854529; rs10970953; rs12551359; rs7850888; rs10813807; rs11787823; rs10970951; rs11999526; rs1854530; rs10117433; rs7034950; rs13302577; rs7037696; rs7873763; rs11999515; rs10813806; rs1556138; rs2026739; rs1467712; rs10970971; rs10813813; rs7026133; rs10435797; rs11793098; rs10813818; rs10511906; rs10758139; rs7022554; rs4878497; rs10813815; rs4879583; rs10970978; rs10738886; rs4442231; rs7874815; rs10123372; rs12001953; rs10970965; rs3814520; rs10970975; rs13290492; rs16918276; rs3814521; rs12555576; rs7855113; rs2375965; rs3780474; rs4879584; rs10813816; rs7019520; rs2068116; rs2026740; rs16918256; rs7032871; rs4879586; rs10758138; rs17288067; rs13293491; rs1467713; rs10970972; rs7855756; rs10970977; rs10970980; rs7037425; rs16918278; rs12379278; rs2274721; rs13292540; rs10813811; rs10970969; rs12554703; rs12238573; rs10970976; rs7874563; rs10970966; rs10738887; rs10970973; rs7871750; rs10813817; rs10970974; rs10813814; rs10970964; rs10970981; rs7043497; rs7042042; rs879450; rs867469; rs41304757; rs41305321; rs41306075; rs7025336; rs3814519; rs41313772; rs41272905; rs35706646; rs35610417; rs28445290; rs11789907; rs4324989; rs36073023; rs10970962; rs5897504; rs13294666; rs10970983; rs9721741; rs7040354; rs10970957; rs7027161; rs7049187; rs10970960; rs7033829; rs11424780; rs7049207; rs11318235; rs34173205; rs28667096; rs10758137; rs34758664; rs3085083; rs10970958; rs12338370; rs10713644; rs4634749; rs10758136; rs35547790; rs7020247; rs10970954; rs7854312; rs7847310; rs7031833; rs7851054; rs7018811; rs1064254; rs10970959; rs35241313; rs5897505; rs1136983; rs41314201; rs34915528; rs35631511; rs10970968; rs35495030; rs4492457; rs34268383; rs41298178; rs41272903; rs7868221; rs34178844; rs10970982; rs34617908; rs11315726; rs34256711; rs13283002; rs34533705; rs10970970; rs34070326; rs7035134; rs35294620; rs35429291; rs1136984; rs35503711; rs35639058; rs34738086; rs10123298; rs12350422; rs35612832; rs7046460; rs34888676; rs7859209; rs34715465; rs34941863; rs7863494; rs12350423; rs12003969; rs7469941; rs11282433; rs34854756; rs13288806; rs7875458; rs11421318; rs9695206; rs34680934; rs16918197; rs5023816; rs16918200; rs34115683; rs34176026; rs35460166; rs1023085; rs1023087; rs1052803; rs10738888; rs10738889; rs10738890; rs10758135; rs10813801; rs10813802; rs10813803; rs10970947; rs10970949; rs10970985; rs10970986; rs10970987; rs10970988; rs1133071; rs12006123; rs12236816; rs12237410; rs12551294; rs12555727; rs1360171; rs17288004; rs17288914; rs17289116; rs3205166; rs35210922; rs35253851; rs36046033; rs7044329; rs7047398; rs7857128; rs7865082; rs9792540

# Metabolic_Enzyme_6_General_References:
1738601; 2172968; 1903202; 1946430

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
6182

# Metabolic_Enzyme_7_Name:
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial precursor

# Metabolic_Enzyme_7_Synonyms:
Isocitric dehydrogenase; NAD(+-specific ICDH

# Metabolic_Enzyme_7_Gene_Name:
IDH3G

# Metabolic_Enzyme_7_Protein_Sequence:
>Isocitrate dehydrogenase NAD subunit gamma, mitochondrial precursor
MALKVATVAGSAAKAVLGPALLCRPWEVLGAHEVPSRNIFSEQTIPPSAKYGGRHTVTMI
PGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDIRNAIMAIRRNRVALKGNIET
NHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDIDILIVRENTEGEYSSLEHE
SVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVA
ARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYG
HVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLASMDNEN
MHTPDIGGQGTTSEAIQDVIRHIRVINGRAVEA

# Metabolic_Enzyme_7_Number_of_Residues:
393

# Metabolic_Enzyme_7_Molecular_Weight:
42795

# Metabolic_Enzyme_7_Theoretical_pI:
8.66

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  isocitrate dehydrogenase activity
Function:  isocitrate dehydrogenase (NAD+) activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  mitochondrion

# Metabolic_Enzyme_7_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_7_Specific_Function:
Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH

# Metabolic_Enzyme_7_Pathway:
map00020  Citrate cycle (TCA cycle)

# Metabolic_Enzyme_7_Reaction:
isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00180:Iso_dh

# Metabolic_Enzyme_7_Signals:
1-30

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.1.1.41

# Metabolic_Enzyme_7_GenBank_ID_Protein:
1167849

# Metabolic_Enzyme_7_SwissProt_ID:
IDH3G_HUMAN (P51553)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
IDH3G

# Metabolic_Enzyme_7_Geneatlas_id:
IDH3G

# Metabolic_Enzyme_7_hgnc_id:
HGNC:5386

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_7_Gene_Sequence:
>1182 bp
ATGGCGCTGAAGGTAGCGACCGTCGCCGGCAGCGCCGCGAAGGCGGTGCTCGGGCCAGCC
CTTCTCTGCCGTCCCTGGGAGGTTCTAGGCGCCCACGAGGTCCCCTCGAGGAACATCTTT
TCAGAACAAACAATTCCTCCGTCCGCTAAGTATGGCGGGCGGCACACGGTGACCATGATC
CCAGGGGATGGCATCGGGCCAGAGCTCATGCTGCATGTCAAGTCCGTCTTCAGGCACGCA
TGTGTACCAGTGGACTTTGAAGAGGTGCACGTGAGTTCCAATGCTGATGAAGAGGACATT
CGCAATGCCATCATGGCCATCCGCCGGAACCGCGTGGCCCTGAAGGGCAACATCGAAACC
AACCATAACCTGCCACCGTCGCACAAATCTCGAAACAACATCCTTCGCACCAGCCTGGAC
CTCTATGCCAACGTCATCCACTGTAAGAGCCTTCCAGGCGTGGTGACCCGGCACAAGGAC
ATAGACATCCTCATTGTCCGGGAGAACACAGAGGGCGAGTACAGCAGCCTGGAGCATGAG
AGTGTGGCGGGAGTGGTGGAGAGCCTGAAGATCATCACCAAGGCCAAGTCCCTGCGCATT
GCCGAGTATGCCTTCAAGCTGGCGCAGGAGAGCGGGCGCAAGAAAGTGACGGCCGTGCAC
AAGGCCAACATCATGAAACTGGGCGATGGGCTTTTCCTCCAGTGCTGCAGGGAGGTGGCA
GCCCGCTACCCTCAGATCACCTTCGAGAACATGATTGTGGATAACACCACCATGCAGCTG
GTGTCCCGGCCCCAGCAGTTTGATGTCATGGTGATGCCCAATCTCTATGGCAACATCGTC
AACAATGTCTGCGCGGGACTGGTCGGGGGCCCAGGCCTTGTGGCTGGGGCCAACTATGGC
CATGTGTACGCGGTGTTTGAAACAGCTACGAGGAACACCGGCAAGAGTATCGCCAATAAG
AACATCGCCAACCCCACGGCCACCCTGCTGGCCAGCTGCATGATGCTGGACCACCTCAAG
CTGCACTCCTATGCCACCTCCATCCGTAAGGCTGTCCTGGCATCCATGGACAATGAGAAT
ATGCACACTCCGGACATCGGGGGCCAGGGCACAACATCTGAAGCCATCCAGGACGTCATC
CGCCACATCCGCGTCATCAACGGCCGGGCCGTGGAGGCCTAG

# Metabolic_Enzyme_7_GenBank_ID_Gene:
Z68907

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_7_Locus:
Xq28

# Metabolic_Enzyme_7_SNPs:
rs2071123; rs2071122; rs2071124; rs17431; rs3788803; rs12558426; rs17429; rs2269482; rs17430; rs17849551; rs11541435; rs11545593; rs11545594; rs41311374; rs34761948; rs7056515; rs41311380; rs4551520; rs34088460; rs5945351; rs7060337; rs1054261; rs1054333; rs11795888; rs12009356; rs12013555; rs17332568; rs1802092; rs1981439; rs2071121; rs2071125; rs2187617; rs2187618; rs2239714; rs2269366; rs2269367; rs2283752; rs2283753; rs2314343; rs34966902; rs4251693; rs4898442; rs4898443; rs4898445; rs4898447; rs5945165; rs5945353; rs5987158; rs6643794; rs762650; rs762651; rs762652; rs877044; rs916001

# Metabolic_Enzyme_7_General_References:
9286695; 10601238; 11256614

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
7812

# Metabolic_Enzyme_8_Name:
OTTHUMP00000030716

# Metabolic_Enzyme_8_Synonyms:
Not Available

# Metabolic_Enzyme_8_Gene_Name:
Not Available

# Metabolic_Enzyme_8_Protein_Sequence:
>
OTTHUMP00000030716MQEAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYM
LYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDVNRL
WSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVV
GAQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEG
YLVFKQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNV
SGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQ
IREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFS
HRCLTIQ

# Metabolic_Enzyme_8_Number_of_Residues:
409

# Metabolic_Enzyme_8_Molecular_Weight:
45546

# Metabolic_Enzyme_8_Theoretical_pI:
5.69

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Not Available

# Metabolic_Enzyme_8_Pathway:
Not Available

# Metabolic_Enzyme_8_Reaction:
Not Available

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 6.2.1.1

# Metabolic_Enzyme_8_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_8_SwissProt_ID:
Q5QPG9_HUMAN (Q5QPG9)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
Not Available

# Metabolic_Enzyme_8_Geneatlas_id:
Not Available

# Metabolic_Enzyme_8_hgnc_id:
Not Available

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Not Available

# Metabolic_Enzyme_8_Gene_Sequence:
Not Available

# Metabolic_Enzyme_8_GenBank_ID_Gene:
AL049709

# Metabolic_Enzyme_8_Chromosome_Location:
Not Available

# Metabolic_Enzyme_8_Locus:
Not Available

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
Not Available

# Metabolic_Enzyme_8_References:
9695922

# Macromolecular_Interacting_Partner_1_ID:
6140

# Macromolecular_Interacting_Partner_1_Name:
NADP-dependent malic enzyme, mitochondrial precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
NADP-ME; Malic enzyme 3

# Macromolecular_Interacting_Partner_1_Gene_Name:
ME3

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>NADPdependent malic enzyme, mitochondrial precursor
MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLN
KGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKL
FYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNI
KAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRD
PLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCM
FNDDIQGTASVAVAGILAALRITNNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKA
EATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGA
FTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGK
TFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLST
IRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMN
VQTV

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
604

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
67055

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.92

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  malate dehydrogenase activity
Function:  malic enzyme activity
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  malate metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Energy production and conversion 

# Macromolecular_Interacting_Partner_1_Specific_Function:
(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH

# Macromolecular_Interacting_Partner_1_Pathway:
map00620  Pyruvate metabolism;
 map00710  Carbon fixation

# Macromolecular_Interacting_Partner_1_Reaction:
(S)-malate + NADP+ = pyruvate + CO2 + NADPH

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00390:malic;
PF03949:Malic_M

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 1.1.1.40

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
535012

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
MAON_HUMAN (Q16798)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
ME3

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
ME3

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6985

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1815 bp
ATGGGTGCCGCGCTGGGGACAGGCACGCGGCTGGCTCCCTGGCCGGGCCGGGCCTGCGGC
GCCCTCCCGCGCTGGACACCCACCGCGCCCGCCCAAGGCTGCCACTCCAAGCCTGGCCCG
GCGCGCCCTGTGCCCCTGAAGAAGCGCGGATACGATGTCACCAGGAACCCTCATCTCAAC
AAGGGGATGGCCTTTACCCTTGAAGAAAGGCTGCAGCTTGGAATCCACGGCCTAATCCCG
CCCTGCTTTCTGAGCCAGGACGTCCAGCTCCTCCGAATCATGAGATATTACGAGCGGCAG
CAGAGTGACCTGGACAAGTACATCATTCTCATGACACTCCAAGACCGGAACGAGAAGCTC
TTCTACCGAGTGCTGACTTCGGATGTGGAGAAGTTCATGCCAATCGTGTACACGCCTACC
GTGGGGCTGGCCTGTCAGCACTATGGCCTGACTTTCCGCAGGCCCCGTGGACTGTTCATC
ACCATTCATGACAAAGGTCATCTTGCAACAATGCTGAATTCTTGGCCAGAAGACAATATT
AAGGCCGTGGTGGTGACTGATGGGGAGCGCATCCTGGGCCTGGGAGACCTGGGCTGCTAC
GGCATGGGCATCCCTGTGGGCAAGCTGGCCCTGTACACGGCATGCGGAGGGGTGAACCCG
CAGCAGTGCCTCCCTGTGCTGCTGGACGTCGGCACCAACAATGAGGAGCTGCTCAGAGAC
CCTCTGTACATCGGCCTGAAACACCAGCGCGTGCACGGGAAGGCATACGATGACTTGCTG
GATGAGTTCATGCAGGCTGTGACAGACAAGTTTGGAATAAATTGCCTCATCCAATTTGAA
GACTTCGCCAATGCCAATGCCTTCCGCCTGCTCAACAAATACCGTAACAAGTACTGCATG
TTCAATGATGACATCCAAGGCACAGCCTCCGTTGCTGTGGCAGGGATCTTGGCTGCTCTG
CGAATCACCAACAACAAGCTTTCCAATCACGTGTTTGTTTTCCAAGGTGCAGGCGAGGCA
GCTATGGGCATTGCCCACCTCCTTGTCATGGCCCTAGAGAAAGAAGGTGTACCGAAGGCA
GAGGCCACAAGAAAGATCTGGATGGTGGACTCTAAAGGGCTCATTGTCAAGGGGAGGAGC
CACCTGAACCATGAAAAGGAGATGTTTGCCCAAGACCATCCTGAAGTCAACTCCCTGGAG
GAGGTGGTGAGGCTGGTGAAGCCCACAGCCATCATAGGTGTTGCTGCCATCGCAGGAGCC
TTCACGGAGCAGATTCTGAGGGACATGGCCTCCTTCCACGAGCGCCCTATCATCTTTGCC
CTGAGCAACCCCACCAGCAAGGCCGAGTGCACGGCTGAGAAGTGCTACCGGGTCACCGAG
GGCCGAGGGATTTTTGCCAGTGGAAGTCCTTTTAAGAGTGTGACTCTGGAAGATGGCAAG
ACCTTCATTCCTGGGCAGGGAAACAATGCTTACGTGTTCCCCGGGGTGGCACTGGGAGTC
ATCGCCGGCGGGATCCGGCACATCCCAGATGAGATCTTCCTCCTGACAGCAGAGCAAATT
GCCCAGGAAGTCTCTGAGCAGCATCTGTCCCAGGGGAGACTCTATCCACCACTCAGCACC
ATCCGAGACGTGTCTTTGAGAATTGCCATCAAAGTTCTCGACTACGCGTACAAACACAAC
CTGGCTTCCTACTACCCAGAGCCTAAGGACAAGGAGGCTTTTGTAAGATCCCTGGTCTAC
ACTCCAGACTATGACTCCTTTACACTGGACAGCTACACTTGGCCCAAGGAAGCCATGAAT
GTTCAGACGGTCTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
X79440

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11cen-q22.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs1042780; rs4943943; rs17211115; rs7946487; rs12287767; rs34662182; rs2446230; rs1945034; rs632873; rs1541310; rs675775; rs677643; rs1541309; rs722158; rs1540082; rs1938921; rs1945142; rs659405; rs2051434; rs624183; rs553351; rs666472; rs587362; rs498981; rs1894012; rs618513; rs539805; rs1938935; rs2226566; rs663262; rs660372; rs679220; rs1938924; rs623478; rs525764; rs632538; rs2511090; rs681333; rs647561; rs658166; rs643414; rs609848; rs2156532; rs634509; rs1458382; rs999472; rs2078385; rs2446228; rs668753; rs601646; rs949349; rs1938931; rs582282; rs1938938; rs651089; rs1945036; rs611156; rs2032356; rs722157; rs622933; rs1938923; rs1938926; rs661163; rs601824; rs616018; rs679076; rs633708; rs538058; rs1841066; rs539939; rs590401; rs4319536; rs4944580; rs7123773; rs655934; rs7950878; rs3819227; rs10219305; rs10898524; rs7109270; rs10219173; rs3824954; rs672526; rs10898501; rs651758; rs609885; rs502749; rs949351; rs7948981; rs10792860; rs7120052; rs1945143; rs7120444; rs7940192; rs4944602; rs4439535; rs7951868; rs6592301; rs10898498; rs626049; rs2279046; rs7112309; rs4144867; rs625925; rs687804; rs493010; rs7122296; rs11607733; rs7940187; rs2446229; rs4944612; rs10898483; rs10898514; rs11234656; rs1945043; rs4944607; rs12285249; rs606546; rs601988; rs1542426; rs585218; rs7117375; rs10444375; rs1938928; rs4943949; rs2051433; rs6592296; rs4405344; rs6592295; rs10792865; rs10792866; rs7103271; rs11234707; rs7941337; rs2446225; rs658324; rs10219319; rs7937853; rs7109521; rs7105863; rs4944613; rs630438; rs7122406; rs4144866; rs2242142; rs7943741; rs1938927; rs10792861; rs638041; rs7940549; rs624843; rs7940654; rs7117234; rs7122928; rs12282010; rs7940523; rs10501627; rs10898484; rs4944596; rs7122479; rs7108055; rs669325; rs7941446; rs4382935; rs7949910; rs12417575; rs7108746; rs4944604; rs12361283; rs4592448; rs7925862; rs662361; rs588287; rs1540083; rs668272; rs6592294; rs4944609; rs7103017; rs611730; rs507123; rs7109853; rs1945145; rs7127944; rs636485; rs1006586; rs677700; rs9787905; rs7122239; rs4944592; rs585749; rs603241; rs1938929; rs2125363; rs601300; rs7106865; rs1458384; rs147045; rs949350; rs4382934; rs7935611; rs1938932; rs4944611; rs4144865; rs630454; rs10501625; rs2511082; rs1945146; rs657378; rs584953; rs7119775; rs605251; rs7116278; rs3758877; rs10898490; rs616794; rs12284853; rs1379872; rs12576144; rs10792854; rs7951185; rs4944593; rs1563682; rs7940587; rs676106; rs10898512; rs10792858; rs12575285; rs7940772; rs579719; rs11819827; rs612163; rs507211; rs7940781; rs11828425; rs12290684; rs6592297; rs10501621; rs7938505; rs659301; rs4245422; rs10792864; rs2168862; rs11825033; rs7117702; rs621653; rs7126717; rs503583; rs10219378; rs4245423; rs10501624; rs17149147; rs11606017; rs3781812; rs7937668; rs638492; rs11234691; rs4944600; rs672266; rs646691; rs613412; rs11826066; rs661328; rs631082; rs7115580; rs10898488; rs598187; rs635934; rs679382; rs10792857; rs4405345; rs10501620; rs10501628; rs628406; rs7930619; rs2279047; rs1945144; rs7118187; rs17819683; rs668270; rs597793; rs7944874; rs17149169; rs4944603; rs10444372; rs635637; rs12797615; rs683899; rs4245420; rs3781813; rs663208; rs647782; rs6592302; rs12804997; rs661954; rs10792856; rs10898515; rs10501623; rs7123010; rs4943945; rs7103556; rs591060; rs653715; rs4245418; rs7934133; rs17211577; rs7125366; rs11234702; rs17211570; rs2155035; rs610790; rs7126810; rs4944614; rs17149234; rs12289252; rs7130920; rs2840368; rs1006587; rs12420965; rs4245424; rs608180; rs561363; rs17819176; rs7940788; rs640310; rs1870323; rs2125362; rs11234662; rs4944610; rs10792855; rs679977; rs10501622; rs585527; rs597296; rs7940590; rs664613; rs7928552; rs10898500; rs593853; rs11821546; rs11234708; rs10792862; rs17149180; rs614995; rs11234719; rs17819523; rs767776; rs1458381; rs4944581; rs2279048; rs7102806; rs2446224; rs583594; rs10898496; rs10898516; rs10501626; rs4245421; rs624236; rs7115834; rs641541; rs10898485; rs10400291; rs10792863; rs17159928; rs11234658; rs7107136; rs1938922; rs7123044; rs12285344; rs677301; rs7941124; rs4245419; rs4944586; rs12281596; rs624870; rs7940448; rs9705039; rs1938925; rs12293809; rs17757676; rs2446226; rs11234676; rs7121583; rs11606042; rs9667152; rs2032355; rs9704409; rs11234731; rs589368; rs10898499; rs11234700; rs7930715; rs687138; rs3889658; rs628449; rs7925379; rs7924879; rs7103642; rs12801189; rs637693; rs12365092; rs531908; rs7949920; rs11234657; rs17818784; rs11234711; rs10898517; rs11234716; rs17211409; rs11234678; rs10444374; rs9645702; rs7128131; rs7116895; rs12798729; rs10898494; rs7130902; rs10898505; rs674250; rs11234683; rs17149242; rs12805940; rs4944616; rs11234729; rs11604162; rs11820663; rs10898507; rs642780; rs7941051; rs619195; rs535652; rs668984; rs11234704; rs7945440; rs969034; rs12291729; rs589174; rs681158; rs11234692; rs12419111; rs2125358; rs3824952; rs12573953; rs7480835; rs12365653; rs566633; rs7125970; rs10898508; rs12269800; rs4245417; rs648798; rs7108710; rs9667168; rs1938918; rs4944585; rs1824279; rs1945139; rs12792674; rs748102; rs12793144; rs12421147; rs7944836; rs590750; rs501362; rs7938344; rs11821635; rs674481; rs10444371; rs12419781; rs17211458; rs12574128; rs4944617; rs643950; rs10792871; rs7104141; rs12283397; rs11234665; rs4944595; rs9943610; rs12285306; rs7945240; rs7938901; rs11234701; rs4943946; rs7952019; rs10898513; rs9645703; rs1945138; rs17211053; rs7943403; rs2155033; rs2212341; rs7938741; rs11828773; rs17818845; rs682501; rs12808738; rs11602862; rs627684; rs4944594; rs12799562; rs1458383; rs11234715; rs9667489; rs10898502; rs1541308; rs1540081; rs12793707; rs7941576; rs10898518; rs2276394; rs511884; rs7926965; rs12364541; rs10898509; rs11234713; rs9667156; rs11234705; rs530278; rs4944587; rs644086; rs11234690; rs11234718; rs1350478; rs539214; rs4944582; rs12277137; rs11606745; rs2212340; rs12222139; rs673118; rs7945260; rs3824953; rs688079; rs12361416; rs12362293; rs661115; rs7948764; rs17149223; rs12420485; rs11234727; rs11234689; rs9943508; rs12804208; rs7935437; rs10898495; rs584068; rs503195; rs4944583; rs7927467; rs593450; rs12224723; rs17149245; rs10898510; rs2511083; rs11607554; rs594106; rs1938920; rs9667775; rs12797575; rs7930401; rs546427; rs4291698; rs11234686; rs12790474; rs4391846; rs11234699; rs1945137; rs10898503; rs11234714; rs7940800; rs12799435; rs7119485; rs4943955; rs12285279; rs2017483; rs7117143; rs12793198; rs7946685; rs7109555; rs7927796; rs11234726; rs998872; rs2446227; rs638135; rs17149197; rs12792300; rs670602; rs596056; rs7930654; rs3758878; rs480290; rs12226269; rs4944597; rs610476; rs2511081; rs751911; rs1938919; rs4944622; rs12288119; rs11602628; rs12280733; rs11234712; rs1945141; rs10898506; rs660893; rs9943611; rs17211563; rs7105382; rs12269985; rs17211584; rs605618; rs10792868; rs694952; rs12575580; rs17149130; rs17149226; rs1945035; rs610842; rs10898493; rs10898504; rs582976; rs7927795; rs12274942; rs17149238; rs10898511; rs653313; rs4943948; rs670736; rs1452138; rs684365; rs1452137; rs1452136; rs4943940; rs589887; rs12283035; rs4944578; rs11823255; rs12294756; rs682915; rs547591; rs7926796; rs12281645; rs10898525; rs35245729; rs3182235; rs15926; rs17852036; rs17845700; rs17856661; rs11556735; rs35059554; rs1062639; rs987649; rs685439; rs656307; rs5793201; rs646798; rs7924919; rs34470258; rs693052; rs12574675; rs7939530; rs11355612; rs11234687; rs34652301; rs618843; rs28895937; rs11518769; rs515798; rs3781806; rs12271274; rs11234668; rs36139518; rs11234673; rs9667498; rs12294332; rs2511089; rs623785; rs4483612; rs654286; rs496167; rs3862787; rs1902958; rs672264; rs34131458; rs12805450; rs582886; rs34631227; rs661972; rs7124538; rs35941464; rs11559614; rs1791443; rs11234709; rs10618233; rs7118346; rs12273697; rs9735826; rs34382146; rs10559080; rs12271571; rs659700; rs34909419; rs11234697; rs34838255; rs11383258; rs672280; rs10545624; rs680846; rs35804280; rs11459186; rs11234720; rs11359686; rs35420773; rs661083; rs4500512; rs12283825; rs28837406; rs34095490; rs12795419; rs618384; rs605255; rs11276982; rs4944620; rs28804208; rs10652368; rs1619882; rs34416639; rs2125360; rs2510498; rs35621612; rs34691357; rs4943952; rs34939684; rs7122008; rs11821842; rs12282012; rs12575681; rs12787395; rs11308452; rs11535845; rs11602146; rs7122667; rs34300602; rs35429348; rs658509; rs550761; rs34659727; rs35175493; rs35291772; rs12794991; rs597823; rs34754668; rs5793204; rs591474; rs10636674; rs657580; rs12362471; rs34832707; rs34557852; rs34946099; rs35892534; rs12294331; rs28603177; rs34313794; rs2219430; rs7934775; rs35187445; rs11234669; rs7929523; rs5793202; rs11601960; rs615371; rs34220027; rs34900435; rs34557683; rs2446231; rs11494278; rs11512936; rs35947577; rs3837399; rs9634021; rs3894263; rs11387187; rs10569902; rs6144422; rs12575999; rs5793205; rs12279297; rs11234664; rs12271552; rs28799720; rs4944590; rs34027067; rs35731805; rs11234696; rs35019870; rs602923; rs686768; rs643072; rs9667181; rs28678569; rs11369958; rs663543; rs12785372; rs4944588; rs11366218; rs2156531; rs11234660; rs12271548; rs34265019; rs604299; rs36152939; rs34764333; rs34278824; rs11392522; rs504635; rs12788873; rs17149146; rs2511085; rs4944579; rs34725712; rs11234721; rs35651342; rs642278; rs663073; rs11560984; rs12292032; rs7103785; rs12788651; rs1938934; rs28446263; rs35122148; rs11828585; rs10676754; rs11271121; rs2852378; rs34224480; rs683408; rs595031; rs11234677; rs617962; rs35557705; rs12269737; rs35393888; rs12417744; rs4943942; rs28825102; rs12804283; rs12804130; rs10672954; rs9705154; rs670825; rs12280101; rs35129724; rs12146569; rs28494065; rs4462374; rs35905440; rs471780; rs11512882; rs12271549; rs11532101; rs7115594; rs11530882; rs4944601; rs2511084; rs11234661; rs2305928; rs35463445; rs635971; rs36152806; rs7107161; rs34988004; rs34080694; rs34877706; rs35748086; rs36124549; rs12280500; rs34887500; rs34028266; rs5793206; rs2226858; rs34061130; rs12222903; rs34405620; rs3045014; rs35163253; rs12805420; rs1235409; rs35546812; rs7939052; rs11530863; rs12293152; rs11302044; rs12794525; rs604128; rs10601910; rs12804026; rs34349106; rs503155; rs34258229; rs653779; rs11512938; rs11234666; rs34699198; rs12291889; rs12362900; rs11234733; rs687669; rs28609643; rs10698015; rs12806468; rs10579155; rs642728; rs7112251; rs28583010; rs4943954; rs11533267; rs12791972; rs28716504; rs35269702; rs35968408; rs10653582; rs34393952; rs11501849; rs11234670; rs34996965; rs11234722; rs596322; rs10652369; rs5793209; rs7102548; rs487960; rs4944618; rs689039; rs34103747; rs12792567; rs34573490; rs12278573; rs35677637; rs34782520; rs12786394; rs10659565; rs34796489; rs4943941; rs35635737; rs12787475; rs10579052; rs35359440; rs627383; rs5793198; rs35222052; rs34315700; rs28452300; rs609855; rs11512934; rs4122041; rs503923; rs581796; rs11561000; rs629038; rs11234685; rs2511086; rs35870909; rs2105784; rs752519; rs12288171; rs679731; rs659781; rs33973657; rs4943950; rs35899335; rs12803885; rs12276356; rs10538002; rs34930310; rs11530862; rs12804089; rs7117530; rs2276393; rs1007948; rs3781808; rs34514194; rs36071853; rs34544991; rs10675389; rs12280100; rs10444373; rs12291626; rs35352939; rs582638; rs11603205; rs661831; rs11234706; rs10559079; rs4471455; rs34334006; rs1060779; rs35625263; rs503949; rs28865371; rs28850038; rs11234667; rs4614483; rs36030892; rs36014844; rs747227; rs11388635; rs28605742; rs35377581; rs7115713; rs619472; rs7124121; rs36012184; rs35255565; rs34698065; rs35650693; rs11234672; rs12805421; rs620054; rs11518768; rs11824279; rs11442101; rs35831878; rs35439198; rs28824521; rs35676005; rs11234730; rs4553393; rs12280255; rs11518770; rs648726; rs5793200; rs5793207; rs12804407; rs35754183; rs34677719; rs34493285; rs619829; rs11234671; rs11501724; rs883190; rs688119; rs648258; rs663627; rs12417361; rs11234717; rs7484000; rs11234688; rs12272130; rs28803287; rs35723009; rs35942916; rs3216158; rs12805438; rs35042210; rs7111906; rs11537258; rs2511080; rs10539253; rs35030247; rs11501841; rs4291697; rs35061999; rs5793199; rs603890; rs1612079; rs35686713; rs35722020; rs35636838; rs12805566; rs10160338; rs11234684; rs35072041; rs34920485; rs2125361; rs11234698; rs1938937; rs509870; rs35086246; rs34385651; rs34267395; rs11305226; rs34371898; rs637758; rs5793203; rs550168; rs11494275; rs34952173; rs11402713; rs561237; rs11234703; rs36107930; rs35726265; rs34433932; rs613418; rs12792072; rs35180248; rs10751139; rs12222272; rs655868; rs34237389; rs34730962; rs34249558; rs12098937; rs36078024; rs35193618; rs10583492; rs35420443; rs34837662; rs34902539; rs11234652; rs11607319; rs11828146; rs12270761; rs12276248; rs12293159; rs1452133; rs1938936; rs2034622; rs2051435; rs2051436; rs2051437; rs2051438; rs3741004; rs4393345; rs516066; rs516746; rs567615; rs571006; rs594361; rs615858; rs642245; rs643157; rs674053; rs693817

# Macromolecular_Interacting_Partner_1_General_References:
7818469

# Macromolecular_Interacting_Partner_1_References:
1440968; 2057233; 2823078

# Macromolecular_Interacting_Partner_2_ID:
8129

# Macromolecular_Interacting_Partner_2_Name:
HLA class I histocompatibility antigen, alpha chain G precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
HLA G antigen

# Macromolecular_Interacting_Partner_2_Gene_Name:
HLA-G

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>HLA class I histocompatibility antigen, alpha chain G precursor
MVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDTQFVRF
DSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEASSHTLQ
WMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAANVAEQR
RAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPAEIILT
WQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLMLRWKQ
SSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
338

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
38224

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.43

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  MHC class I receptor activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
Process:  antigen presentation
 ||
>>>
Component:  protein complex
Component:  MHC protein complex
Component:  MHC class I protein complex

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Involved in the presentation of foreign antigens to the immune system

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF07654:C1-set;
PF00129:MHC_I

# Macromolecular_Interacting_Partner_2_Signals:
1-24

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
309-332

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
32147

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
HLAG_HUMAN (P17693)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
HLA-G

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
HLA-G

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:4964

# Macromolecular_Interacting_Partner_2_PDB_ID:
1YDP

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1017 bp
ATGGTGGTCATGGCGCCCCGAACCCTCTTCCTGCTGCTCTCGGGGGCCCTGACCCTGACC
GAGACCTGGGCGGGCTCCCACTCCATGAGGTATTTCAGCGCCGCCGTGTCCCGGCCCGGC
CGCGGGGAGCCCCGCTTCATCGCCATGGGCTACGTGGACGACACGCAGTTCGTGCGGTTC
GACAGCGACTCGGCGTGTCCGAGGATGGAGCCGCGGGCGCCGTGGGTGGAGCAGGAGGGG
CCGGAGTATTGGGAAGAGGAGACACGGAACACCAAGGCCCACGCACAGACTGACAGAATG
AACCTGCAGACCCTGCGCGGCTACTACAACCAGAGCGAGGCCAGTTCTCACACCCTCCAG
TGGATGATTGGCTGCGACCTGGGGTCCGACGGACGCCTCCTCCGCGGGTATGAACAGTAT
GCCTACGATGGCAAGGATTACCTCGCCCTGAACGAGGACCTGCGCTCCTGGACCGCAGCG
GACACTGCGGCTCAGATCTCCAAGCGCAAGTGTGAGGCGGCCAATGTGGCTGAACAAAGG
AGAGCCTACCTGGAGGGCACGTGCGTGGAGTGGCTCCACAGATACCTGGAGAACGGGAAG
GAGATGCTGCAGCGCGCGGACCCCCCCAAGACACACGTGACCCACCACCCTGTCTTTGAC
TATGAGGCCACCCTGAGGTGCTGGGCCCTGGGCTTCTACCCTGCGGAGATCATACTGACC
TGGCAGCGGGATGGGGAGGACCAGACCCAGGACGTGGAGCTCGTGGAGACCAGGCCTGCA
GGGGATGGAACCTTCCAGAAGTGGGCAGCTGTGGTGGTGCCTTCTGGAGAGGAGCAGAGA
TACACGTGCCATGTGCAGCATGAGGGGCTGCCGGAGCCCCTCATGCTGAGATGGAAGCAG
TCTTCCCTGCCCACCATCCCCATCATGGGTATCGTTGCTGGCCTGGTTGTCCTTGCAGCT
GTAGTCACTGGAGCTGCGGTCGCTGCTGTGCTGTGGAGAAAGAAGAGCTCAGATTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
X17273

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_2_Locus:
6p21.3

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
2336406; 3480534; 10727083

# Macromolecular_Interacting_Partner_2_References:
10559181; 10983413; 14568142; 17142397

End of HMDB00193

Beginning of HMDB00194
# Accession_No:
HMDB00194

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-07-20 03:17:52

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Anserine

# Description:
This dipeptide is normally absent from human tissues and body fluids, and its appearance there is an artifact of diet (Proc Soc Pediatr Res 134, 1967.) and serum carnosinase deficiency. (OMIM 212200) Anserine is present in the skeletal muscle of birds and certain species of mammals, notably the rabbit, rat, and whale, contains anserine. (Proc Soc Pediatr Res 134, 1967)  The methyl group of anserine is added to carnosine by the enzyme S-adenosylmethionine: carnosine N-methyltransferase. (J Biol Chem 237:1207, 1962.)

# Synonyms:
Anserine; L-Anserine; L-N-b-alanyl-3-methyl-Histidine; N-b-alanyl-3-methyl-L-Histidine; N-beta-Alanyl-3-methyl-L-histidine; beta-alanyl-N(pai)-methyl-L-histidine; L-N-beta-alanyl-3-methyl-Histidine

# Chemical_IUPAC_Name:
2-(3-aminopropanoylamino)-3-(3-methylimidazol-4-yl)-propanoic acid

# Chemical_Formula:
C10H16N4O3

# Chemical_Structure:
tbl_chemical:::HMDB00194_ZOOM.png:::11928324582506897

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00194_THUMB.png:::119283245622023062

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid; secondary carboxylic acid amide; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
240.12224

# Molecular_Weight_Avg:
240.25903

# Smiles_String_isomeric:
CN1C=NC=C1C[C@H](NC(=O)CCN)C(O)=O

# Smiles_String_canonical:
CN1C=NC=C1CC(NC(=O)CCN)C(O)=O

# KEGG_Compound_ID:
C01262

# BioCyc_ID:
Not Available

# PubChem_CID:
112072

# PubChem_SID:
10629587; 8143813; 4481

# OMIM_ID:
212200

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Anserine

# METLIN_ID:
5209

# Ref_ID:
16554972; 9917666; 8224369; 10701790; 10079554; 9777271; 10079975

# ChEBI_ID:
18323

# CAS_Registry_Number:
584-85-0

# InChI:
InChI=1/C10H16N4O3/c1-14-6-12-5-7(14)4-8(10(16)17)13-9(15)2-3-11/h5-6,8H,2-4,11H2,1H3,(H,13,15)(H,16,17)/t8-/m0/s1

# Synthesis_Reference:
Rinderknecht, H. et al., J.O.C., 1964, 29, 1968

# Melting_Point:
226-228 oC

# Melting_Point_predicted:
103.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
15.8 mg/mL [MEYLAN,WM et al. (1996)]; 4.01 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.94 [Predicted by ALOGPS]; -3.8 [Predicted by PubChem via XLOGP]; -1.26 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C01262.mol:::1132723813218367092

# SDF_File_[Text]:
tbl_chemical:::HMDB00194.sdf:::119283245250456674

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00194.pdb:::119283245483399422

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Anserine.gif:::115325158700520106

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00194_peaks.txt:::1156309610440777682

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Anserine_C.gif:::11532515870212941

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00194_peaks.txt:::1156310799720899487

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00194L.png:::117555265900621969; Medium Energy:tbl_ms:::HMDB00194M.png:::117555270234586497; High Energy:tbl_ms:::HMDB00194H.png:::117555272372921175

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Muscles; Brain

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	<5.921	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Bursitis; Tendinitis

# Pathway_Names:
Not Available

# Pathway_Images:
Not Available

# KEGG_Images:
Not Available

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5713

# Metabolic_Enzyme_1_Name:
Beta-Ala-His dipeptidase precursor

# Metabolic_Enzyme_1_Synonyms:
Carnosine dipeptidase 1; CNDP dipeptidase 1; Serum carnosinase; Glutamate carboxypeptidase-like protein 2

# Metabolic_Enzyme_1_Gene_Name:
CNDP1

# Metabolic_Enzyme_1_Protein_Sequence:
>BetaAlaHis dipeptidase precursor
MDPKLGRMAASLLAVLLLLLERGMFSSPSPPPALLEKVFQYIDLHQDEFVQTLKEWVAIE
SDSVQPVPRFRQELFRMMAVAADTLQRLGARVASVDMGPQQLPDGQSLPIPPVILAELGS
DPTKGTVCFYGHLDVQPADRGDGWLTDPYVLTEVDGKLYGRGATDNKGPVLAWINAVSAF
RALEQDLPVNIKFIIEGMEEAGSVALEELVEKEKDRFFSGVDYIVISDNLWISQRKPAIT
YGTRGNSYFMVEVKCRDQDFHSGTFGGILHEPMADLVALLGSLVDSSGHILVPGIYDEVV
PLTEEEINTYKAIHLDLEEYRNSSRVEKFLFDTKEEILMHLWRYPSLSIHGIEGAFDEPG
TKTVIPGRVIGKFSIRLVPHMNVSAVEKQVTRHLEDVFSKRNSSNKMVVSMTLGLHPWIA
NIDDTQYLAAKRAIRTVFGTEPDMIRDGSTIPIAKMFQEIVHKSVVLIPLGAVDDGEHSQ
NEKINRWNYIEGTKLFAAFFLEMAQLH

# Metabolic_Enzyme_1_Number_of_Residues:
507

# Metabolic_Enzyme_1_Molecular_Weight:
56693

# Metabolic_Enzyme_1_Theoretical_pI:
4.95

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  protein dimerization activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  metallopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_1_Pathway:
map00340  Histidine metabolism;
 map00410  beta-Alanine metabolism

# Metabolic_Enzyme_1_Reaction:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF07687:M20_dimer;
PF01546:Peptidase_M20

# Metabolic_Enzyme_1_Signals:
1-26

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.4.13.20

# Metabolic_Enzyme_1_GenBank_ID_Protein:
16555792

# Metabolic_Enzyme_1_SwissProt_ID:
CNDP1_HUMAN (Q96KN2)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
CNDP1

# Metabolic_Enzyme_1_Geneatlas_id:
CNDP1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:20675

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_1_Gene_Sequence:
>1527 bp
ATGGATCCCAAACTCGGGAGAATGGCTGCGTCCCTGCTGGCTGTGCTGCTGCTGCTGCTG
CTGGAGCGCGGCATGTTCTCCTCACCCTCCCCGCCCCCGGCGCTGTTAGAGAAAGTCTTC
CAGTACATTGACCTCCATCAGGATGAATTTGTGCAGACGCTGAAGGAGTGGGTGGCCATC
GAGAGCGACTCTGTCCAGCCTGTGCCTCGCTTCAGACAAGAGCTCTTCAGAATGATGGCC
GTGGCTGCGGACACGCTGCAGCGCCTGGGGGCCCGTGTGGCCTCGGTGGACATGGGTCCT
CAGCAGCTGCCCGATGGTCAGAGTCTTCCAATACCTCCCGTCATCCTGGCCGAACTGGGG
AGCGATCCCACGAAAGGCACCGTGTGCTTCTACGGCCACTTGGACGTGCAGCCTGCTGAC
CGGGGCGATGGGTGGCTCACGGACCCCTATGTGCTGACGGAGGTAGGCGGGAAACTTTAT
GGACGAGGAGCGACCGACAACAAAGGCCCTGTCTTGGCTTGGATCAATGCTGTGAGCGCC
TTCAGAGCCCTGGAGCAAGATCTTCCTGTGAATATCAAATTCATCATTGAGGGGATGGAA
GAGGCTGGCTCTGTTGCCCTGGAGGAACTTGTGGAAAAAGAAAAGGACCGATTCTTCTCT
GGTGTGGACTACATTGTAATTTCAGATAACCTGTGGATCAGCCAAAGGAAGCTAGCAATC
ACTTACGGAACCCGGGGGAACAGCTACTTCATGGTGGAGGTGAAATGCAGAGACCAGGAT
TTTCACTCAGGAACCTTTGGTGGCATCCTTCATGAACTAATGGCTGATCTGGTTGCTCTT
CTCGGTAGCCTGGTAGACTCGTCTGGTCATATCCTGGTCCCTGGAATCTATGATGAAGTG
GTTCCTCTTACAGAAGAGGAAATAAATACATACAAAGCCATCCATCTAGACCTAGAAGAA
TACCGGAATAGCAGCCGGGTTGAGAAATTTCTGTTCGATACTAAGGAGGAGATTCTAATG
CACCTCTGGAGGTACCCATCTCTTTCTATTCATGGGATCGAGGGCGCGTTTGATGAGCCT
GGAACTAAAACAGTCATACCTGGCCGAGTTATAGGAAAATTTTCAATCCGTCTAGTCCCT
CACATGAATGTGTCTGCGGTGGAAAAACAGGTGACACGACATCTTGAAGATGTGTTCTCC
AAAAGAAATAGTTCCAACAAGATGGTTGTTTCCATGACTCTAGGACTACACCCGTGGATT
GCAAATATTGATGACACTCAGTATCTCGCAGCAAAAAGAGCGATCAGAACAGTGTTTGGA
ACAGAACCAGATATGATCCGGGATGGATCCACCATTCCAATTGCCAAAATGTTCCAGGAG
ATCGTCCACAAGAGCGTGGTGCTAATTCCGCTGGGAGCTGTTGATGATGGAGAACATTCG
CAGAATGAGAAAATCAACAGGTGGAACTACATAGAGGGAACCAAATTATTTGCTGCCTTT
TTCTTAGAGATGGCCCAGCTCCATTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AJ417564

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:18

# Metabolic_Enzyme_1_Locus:
18q22.3

# Metabolic_Enzyme_1_SNPs:
rs4263028; rs11151964; rs9807352; rs12960862; rs2887; rs4891564; rs2346064; rs1004453; rs7239132; rs12604675; rs10469123; rs10469203; rs12607796; rs12605490; rs8087768; rs9319909; rs4892246; rs7506171; rs4329999; rs7242384; rs8085167; rs11876996; rs7244370; rs7506929; rs4892243; rs7231312; rs4892242; rs12605520; rs733686; rs9967490; rs7229005; rs7232853; rs1426256; rs7506957; rs17817095; rs11875756; rs7506825; rs17817180; rs12961730; rs12964027; rs12456406; rs12964208; rs7506760; rs12956997; rs12456388; rs12964454; rs11873844; rs17817345; rs7505047; rs17089382; rs17089414; rs17089390; rs7233066; rs9953129; rs9960024; rs11659237; rs9807248; rs11662276; rs17816861; rs11873901; rs10469124; rs17089403; rs1559809; rs17817077; rs9949100; rs4891563; rs11661606; rs2881289; rs7228575; rs9957229; rs9955944; rs17089375; rs4892244; rs17089411; rs4892239; rs17238585; rs7505555; rs12326826; rs9946796; rs11876764; rs9949990; rs34570315; rs12957330; rs7506936; rs4892241; rs7506258; rs9952652; rs4355018; rs9957885; rs11664748; rs4133234; rs17238285; rs1974965; rs11659364; rs4892238; rs11875122; rs7237549; rs9948919; rs12959707; rs12457983; rs12964810; rs1974963; rs4891562; rs11873542; rs12962343; rs2881288; rs17089378; rs12954161; rs9959794; rs7504932; rs12327522; rs11664535; rs7230673; rs12455650; rs1974964; rs7244647; rs9989559; rs11875810; rs12954438; rs2098910; rs2346061; rs2346063; rs890333; rs2346062; rs2081548; rs890332; rs11538620; rs34522443; rs11538622; rs11538624; rs11538623; rs35604255; rs10533212; rs35771415; rs34713611; rs9967349; rs33922160; rs34365714; rs34526667; rs11875787; rs28448542; rs28871039; rs35084313; rs10549931; rs10685765; rs34874693; rs4891561; rs12606902; rs34117300; rs12959038; rs36228963; rs5826336; rs35735348; rs34499247; rs35885130; rs35388041; rs28713380; rs11151965; rs34138697; rs35204551; rs9966983; rs7505007; rs35096494; rs33950634; rs33981863; rs34142328; rs12959706; rs9955580; rs9947243; rs34869467; rs35788286; rs10624462; rs34283867; rs6566813; rs34962477; rs34335073; rs5826332; rs36060345; rs34573470; rs35682790; rs35362460; rs35860275; rs35365788; rs12964034; rs10522670; rs12959748; rs4892245; rs36111704; rs12969794; rs5826335; rs4891560; rs9965945; rs34070364; rs10624665; rs5826334; rs34842524; rs35877440; rs34785330; rs17089373; rs7233122; rs10596720; rs9948674; rs34189472; rs10562152; rs10649703; rs34321505; rs35707511; rs9949211; rs35368997; rs35691581; rs35734110; rs9953867; rs34563384; rs35469246; rs8087111; rs34726849; rs35932028; rs12969795; rs12969769; rs34799288; rs35234907; rs28800835; rs34646410; rs10685766; rs34895018; rs35597919; rs12961586; rs6566814; rs28877095; rs4892240; rs33911381; rs8088199; rs11872770; rs36206459; rs7350982; rs34145828; rs11447097; rs12104001; rs4892247; rs3080879; rs10663835; rs10871736; rs10871737; rs1130046; rs11664131; rs12327049; rs12456405; rs12954579; rs12966495; rs12967519; rs12970020; rs17089369; rs2114228; rs28534519; rs35248661; rs4353545; rs4891565; rs4891566; rs4892233; rs4892248; rs4892249; rs6566815; rs7238101; rs7504377; rs7506051; rs7506112; rs8096427; rs8099458; rs9319908

# Metabolic_Enzyme_1_General_References:
12975309

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5712

# Metabolic_Enzyme_2_Name:
Ceruloplasmin precursor

# Metabolic_Enzyme_2_Synonyms:
Ferroxidase

# Metabolic_Enzyme_2_Gene_Name:
CP

# Metabolic_Enzyme_2_Protein_Sequence:
>Ceruloplasmin precursor
MKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGP
DRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFH
SHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYH
SHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYC
SEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFH
GQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKS
SSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSY
KKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGV
RFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYY
SAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMF
TTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYF
SGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRR
QSEDSTFYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYK
KVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQ
TESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVC
RRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHA
INGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFP
GTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNEDTKSG

# Metabolic_Enzyme_2_Number_of_Residues:
1065

# Metabolic_Enzyme_2_Molecular_Weight:
122206

# Metabolic_Enzyme_2_Theoretical_pI:
5.50

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_2_Specific_Function:
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing iron(II) to iron(III) without releasing radical oxygen species. It is involved in iron transport across the cell membrane

# Metabolic_Enzyme_2_Pathway:
map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_2_Reaction:
4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00394:Cu-oxidase;
PF07731:Cu-oxidase_2;
PF07732:Cu-oxidase_3

# Metabolic_Enzyme_2_Signals:
1-19

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.16.3.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
180256

# Metabolic_Enzyme_2_SwissProt_ID:
CERU_HUMAN (P00450)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
CP

# Metabolic_Enzyme_2_Geneatlas_id:
CP

# Metabolic_Enzyme_2_hgnc_id:
HGNC:2295

# Metabolic_Enzyme_2_PDB_ID:
1KCW

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_2_Gene_Sequence:
>3198 bp
ATGAAGATTTTGATACTTGGTATTTTTCTGTTTTTATGTAGTACCCCAGCCTGGGCGAAA
GAAAAGCATTATTACATTGGAATTATTGAAACGACTTGGGATTATGCCTCTGACCATGGG
GAAAAGAAACTTATTTCTGTTGACACGGAACATTCCAATATCTATCTTCAAAATGGCCCA
GATAGAATTGGGAGACTATATAAGAAGGCCCTTTATCTTCAGTACACAGATGAAACCTTT
AGGACAACTATAGAAAAACCGGTCTGGCTTGGGTTTTTAGGCCCTATTATCAAAGCTGAA
ACTGGAGATAAAGTTTATGTACACTTAAAAAACCTTGCCTCTAGGCCCTACACCTTTCAT
TCACATGGAATAACTTACTATAAGGAACATGAGGGGGCCATCTACCCTGATAACACCACA
GATTTTCAAAGAGCAGATGACAAAGTATATCCAGGAGAGCAGTATACATACATGTTGCTT
GCCACTGAAGAACAAAGTCCTGGGGAAGGAGATGGCAATTGTGTGACTAGGATTTACCAT
TCCCACATTGATGCTCCAAAAGATATTGCCTCAGGACTCATCGGACCTTTAATAATCTGT
AAAAAAGATTCTCTAGATAAAGAAAAAGAAAAACATATTGACCGAGAATTTGTGGTGATG
TTTTCTGTGGTGGATGAAAATTTCAGCTGGTACCTAGAAGACAACATTAAAACCTACTGC
TCAGAACCAGAGAAAGTTGACAAAGACAACGAAGACTTCCAGGAGAGTAACAGAATGTAT
TCTGTGAATGGATACACTTTTGGAAGTCTCCCAGGACTCTCCATGTGTGCTGAAGACAGA
GTAAAATGGTACCTTTTTGGTATGGGTAATGAAGTTGATGTGCACGCAGCTTTCTTTCAC
GGGCAAGCACTGACTAACAAGAACTACCGTATTGACACAATCAACCTCTTTCCTGCTACC
CTGTTTGATGCTTATATGGTGGCCCAGAACCCTGGAGAATGGATGCTCAGCTGTCAGAAT
CTAAACCATCTGAAAGCCGGTTTGCAAGCCTTTTTCCAGGTCCAGGAGTGTAACAAGTCT
TCATCAAAGGATAATATCCGTGGGAAGCATGTTAGACACTACTACATTGCCGCTGAGGAA
ATCATCTGGAACTATGCTCCCTCTGGTATAGACATCTTCACTAAAGAAAACTTAACAGCA
CCTGGAAGTGACTCAGCGGTGTTTTTTGAACAAGGTACCACAAGAATTGGAGGCTCTTAT
AAAAAGCTGGTTTATCGTGAGTACACAGATGCCTCCTTCACAAATCGAAAGGAGAGAGGC
CCTGAAGAAGAGCATCTTGGCATCCTGGGTCCTGTCATTTGGGCAGAGGTGGGAGACACC
ATCAGAGTAACCTTCCATAACAAAGGAGCATATCCCCTCAGTATTGAGCCGATTGGGGTG
AGATTCAATAAGAACAACGAGGGCACATACTATTCCCCAAATTACAACCCCCAGAGCAGA
AGTGTGCCTCCTTCAGCCTCCCATGTGGCACCCACAGAAACATTCACCTATGAATGGACT
GTCCCCAAAGAAGTAGGACCCACTAATGCAGATCCTGTGTGTCTAGCTAAGATGTATTAT
TCTGCTGTGGATCCCACTAAAGATATATTCACTGGGCTTATTGGGCCAATGAAAATATGC
AAGAAAGGAAGTTTACATGCAAATGGGAGACAGAAAGATGTAGACAAGGAATTCTATTTG
TTTCCTACAGTATTTGATGAGAATGAGAGTTTACTCCTGGAAGATAATATTAGAATGTTT
ACAACTGCACCTGATCAGGTGGATAAGGAAGATGAAGACTTTCAGGAATCTAATAAAATG
CACTCCATGAATGGATTCATGTATGGGAATCAGCCGGGTCTCACTATGTGCAAAGGAGAT
TCGGTCGTGTGGTACTTATTCAGCGCCGGAAATGAGGCCGATGTACATGGAATATACTTT
TCAGGAAACACATATCTGTGGAGAGGAGAACGGAGAGACACAGCAAACCTCTTCCCTCAA
ACAAGTCTTACGCTCCACATGTGGCCTGACACAGAGGGGACTTTTAATGTTGAATGCCTT
ACAACTGATCATTACACAGGCGGCATGAAGCAAAAATATACTGTGAACCAATGCAGGCGG
CAGTCTGAGGATTCCACCTTCTACCTGGGAGAGAGGACATACTATATCGCAGCAGTGGAG
GTGGAATGGGATTATTCCCCACAAAGGGAGTGGGAAAAGGAGCTGCATCATTTACAAGAG
CAGAATGTTTCAAATGCATTTTTAGATAAGGGAGAGTTTTACATAGGCTCAAAGTACAAG
AAAGTTGTGTATCGGCAGTATACTGATAGCACATTCCGTGTTCCAGTGGAGAGAAAAGCT
GAAGAAGAACATCTGGGAATTCTAGGTCCACAACTTCATGCAGATGTTGGAGACAAAGTC
AAAATTATCTTTAAAAACATGGCCACAAGGCCCTACTCAATACATGCCCATGGGGTACAA
ACAGAGAGTTCTACAGTTACTCCAACATTACCAGGTGAAACTCTCACTTACGTATGGAAA
ATCCCAGAAAGATCTGGAGCTGGAACAGAGGATTCTGCTTGTATTCCATGGGCTTATTAT
TCAACTGTGGATCAAGTTAAGGACCTCTACAGTGGATTAATTGGCCCCCTGATTGTTTGT
CGAAGACCTTACTTGAAAGTATTCAATCCCAGAAGGAAGCTGGAATTTGCCCTTCTGTTT
CTAGTTTTTGATGAGAATGAATCTTGGTACTTAGATGACAACATCAAAACATACTCTGAT
CACCCCGAGAAAGTAAACAAAGATGATGAGGAATTCATAGAAAGCAATAAAATGCATGCT
ATTAATGGAAGAATGTTTGGAAACCTACAAGGCCTCACAATGCACGTGGGAGATGAAGTC
AACTGGTATCTGATGGGAATGGGCAATGAAATAGACTTACACACTGTACATTTTCACGGC
CATAGCTTCCAATACAAGCACAGGGGAGTTTATAGTTCTGATGTCTTTGACATTTTCCCT
GGAACATACCAAACCCTAGAAATGTTTCCAAGAACACCTGGAATTTGGTTACTCCACTGC
CATGTGACCGACCACATTCATGCTGGAATGGAAACCACTTACACCGTTCTACAAAATGAA
GACACCAAATCTGGCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M13699

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_2_Locus:
3q23-q25

# Metabolic_Enzyme_2_SNPs:
rs34624984; rs701753; rs1053709; rs34237139; rs34394958; rs35438054; rs9834971; rs1523514; rs6799507; rs772908; rs12496866; rs6768350; rs1523513; rs4974389; rs11917114; rs701755; rs3107836; rs34004251; rs16861576; rs11919626; rs16861598; rs1879169; rs16861602; rs16861633; rs6440590; rs11922514; rs16861593; rs773050; rs16861577; rs35284835; rs16861582; rs34171195; rs3736282; rs16861590; rs16861588; rs7632958; rs16861634; rs11714000; rs11924891; rs17847023; rs34951015; rs10935743; rs11921705; rs3816893; rs11709714; rs34865491; rs16861579; rs17787768; rs7632964; rs16861637; rs11924961; rs16861596; rs701751; rs3765125; rs701754; rs10935742; rs7652826; rs9853335; rs6792209; rs34861155; rs11915834; rs1523515; rs9841442; rs35593818; rs35610536; rs34481162; rs34300334; rs35903829; rs2681084; rs13072552; rs34175628; rs13092519; rs13095262; rs34626625; rs35191080; rs36074020; rs696994; rs772904; rs34079352; rs36021368; rs35229573; rs35966950; rs34013572; rs36098024; rs35773127; rs35386382; rs35876747; rs34649438; rs36106034; rs34443048; rs34656703; rs35716500; rs35272481; rs34067682; rs34042451; rs35899708; rs35378125; rs34842353; rs35653745; rs35123935; rs1908053; rs35165738; rs34930306; rs34650204; rs34052330; rs34617132; rs798842; rs35727759; rs35062355; rs34654392; rs1879168; rs35767691; rs34770768; rs16861639; rs13075891; rs34010341; rs34535555; rs34011114; rs35529745; rs34335440; rs13084448; rs34335607; rs11710581; rs34867923; rs35541542; rs34504513; rs34454179; rs36103494; rs36099841; rs35244189; rs34586382; rs16861636; rs13075921; rs34823342; rs13080467; rs35216818; rs34753475; rs34296476; rs772907; rs35334247; rs11288866; rs35516209; rs34907627; rs34670346; rs34091282; rs7634054; rs34645589; rs34516709; rs34312834; rs35848147; rs35198307; rs35976863; rs35090057; rs10935744; rs35364670; rs34049286; rs7632719; rs34155161; rs35904683; rs36027953; rs35718216; rs35503313; rs34142100; rs35358026; rs809554; rs34414552; rs34751274; rs35149808; rs35048481; rs701748; rs3755644; rs696993; rs701749; rs35682120; rs17838832; rs36024032; rs35691438; rs17838831; rs35622518; rs35474921; rs17838834; rs34851340; rs17838833; rs17847018; rs11553309; rs2681095; rs35331711; rs2640038; rs34386552; rs17847026; rs34987997; rs17847022; rs17847025; rs13314294; rs1063899; rs17847016; rs11553308; rs35142039; rs35334652; rs9833860; rs13080302; rs10540828; rs34817492; rs2681098; rs35103260; rs11920882; rs12107157; rs35879864; rs798841; rs34855818; rs35885078; rs17847019; rs28722677; rs701750; rs34399626; rs35132881; rs3103861; rs35551942; rs35238123; rs2933882; rs2640037; rs2681094; rs28657647; rs34861029; rs2640042; rs7623387; rs28361508; rs35019965; rs36103142; rs811635; rs6767930; rs10718513; rs13062843; rs9833659; rs34251410; rs9653952; rs809553; rs35465173; rs11926259; rs2681099; rs35766301; rs34321384; rs35942827; rs34375295; rs10663585; rs34372049; rs34929084; rs2681083; rs34355891; rs35721007; rs4974392; rs35900668; rs41267873; rs34841236; rs34145911; rs11451281; rs34568785; rs34757057; rs34750070; rs17847028; rs34113826; rs2640039; rs12487772; rs11380808; rs2933883; rs2933884; rs35193625; rs35236994; rs35752872; rs2681080; rs810089; rs35652604; rs34875136; rs10573853; rs10631065; rs35048131; rs35288810; rs34437667; rs13091064; rs34556731; rs35102207; rs9821640; rs34700374; rs34230520; rs34241019; rs10576836; rs34686915; rs3736520; rs701757; rs2946680; rs34895769; rs35927352; rs2640044; rs35196125; rs34550573; rs35076221; rs772906; rs34343199; rs34696248; rs35850459; rs35090033; rs35204894; rs34636664; rs701752; rs13079008; rs34445333; rs35267205; rs34315195; rs34873592; rs9857073; rs35360246; rs2681100; rs34016079; rs35335199; rs2640041; rs35974775; rs34523231; rs34832681; rs2681097; rs13091078; rs2681086; rs34171193; rs35682875; rs10661618; rs2971562; rs34575419; rs810088; rs35387181; rs34239280; rs3070607; rs35855023; rs17847024; rs36107315; rs17847017; rs2640043; rs35913214; rs2681082; rs6777849; rs34003547; rs34938986; rs11374895; rs11309557; rs34618068; rs11347585; rs35972521; rs34587777; rs701756; rs2933885; rs2681093; rs35886571; rs2640040; rs35068918; rs13068416; rs34168096; rs28390156; rs34571365; rs28408096; rs36074830; rs13068197; rs35937468; rs35816853; rs35358355; rs11288867; rs812829; rs36036828; rs35296558; rs2681085; rs34510606; rs34053109; rs35633059; rs34334174; rs34109328; rs34110798; rs11708215; rs11720427; rs12494334; rs13066364; rs13095764; rs13096289; rs13098532; rs16846602; rs16861642; rs16861645; rs16861646; rs16861647; rs16861649; rs17195505; rs2177392; rs2681092; rs2681096; rs2681101; rs2981470; rs2981471; rs34060990; rs35196849; rs35355363; rs35371359; rs35555422; rs3732557; rs3755641; rs3755642; rs4681170; rs4681490; rs7623663; rs9877778

# Metabolic_Enzyme_2_General_References:
2873574; 7702601; 3755405; 3486416; 6582496; 6571985; 6940148; 6987229; 6987230; 2355023; 12055353

# Metabolic_Enzyme_2_References:
11911459; 12132593

# Metabolic_Enzyme_3_ID:
5922

# Metabolic_Enzyme_3_Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4A

# Metabolic_Enzyme_3_Synonyms:
DPDE2; PDE46

# Metabolic_Enzyme_3_Gene_Name:
PDE4A

# Metabolic_Enzyme_3_Protein_Sequence:
>cAMPspecific 3',5'cyclic phosphodiesterase 4
AMEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERER
QPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPG
RSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVT
PFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELD
WCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVE
IPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKT
DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM
LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG
VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVID
MVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPL
ELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD
LVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE
EISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYL
TQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGL
PSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT

# Metabolic_Enzyme_3_Number_of_Residues:
886

# Metabolic_Enzyme_3_Molecular_Weight:
98144

# Metabolic_Enzyme_3_Theoretical_pI:
4.87

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_3_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_3_GenBank_ID_Protein:
347120

# Metabolic_Enzyme_3_SwissProt_ID:
PDE4A_HUMAN (P27815)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
PDE4A

# Metabolic_Enzyme_3_Geneatlas_id:
PDE4A

# Metabolic_Enzyme_3_hgnc_id:
HGNC:8780

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Isoform 4:Membrane; peripheral membrane protein. Note=Isoform 4 has propensity for association with membranes

# Metabolic_Enzyme_3_Gene_Sequence:
>2661 bp
ATGGAACCCCCGACCGTCCCCTCGGAAAGGAGCCTGTCTCTGTCACTGCCCGGGCCCCGG
GAGGGCCAGGCCACCCTGAAGCCTCCCCCGCAGCACCTGTGGCGGCAGCCTCGGACCCCC
ATCCGTATCCAGCAGCGCGGCTACTCCGACAGCGCGGAGCGCGCCGAGCGGGAGCGGCAG
CCGCACCGGCCCATAGAGCGCGCCGATGCCATGGACACCAGCGACCGGCCCGGCCTGCGC
ACGACCCGCATGTCCTGGCCCTCGTCCTTCCATGGCACTGGCACCGGCAGCGGCGGCGCG
GGCGGAGGCAGCAGCAGGCGCTTCGAGGCAGAGAATGGGCCGACACCATCTCCTGGCCGC
AGCCCCCTGGACTCGCAGGCGAGCCCAGGACTCGTGCTGCACGCCGGGGCGGCCACCAGC
CAGCGCCGGGAGTCCTTCCTGTACCGCTCAGACAGCGACTATGACATGTCACCCAAGACC
ATGTCCCGGAACTCATCGGTCACCAGCGAGGCGCACGCTGAAGACCTCATCGTAACACCA
TTTGCTCAGGTGCTGGCCAGCCTCCGGAGCGTCCGTAGCAACTTCTCACTCCTGACCAAT
GTGCCCGTTCCCAGTAACAAGCGGTCCCCGCTGGGCGGCCCCACCCCTGTCTGCAAGGCC
ACGCTGTCAGAAGAAACGTGTCAGCAGTTGGCCCGGGAGACTCTGGAGGAGCTGGACTGG
TGTCTGGAGCAGCTGGAGACCATGCAGACCTATCGCTCTGTCAGCGAGATGGCCTCGCAC
AAGTTCAAAAGGATGTTGAACCGTGAGCTCACACACCTGTCAGAAATGAGCAGGTCCGGA
AACCAGGTCTCAGAGTACATTTCCACAACATTCCTGGACAAACAGAATGAAGTGGAGATC
CCATCACCCACGATGAAGGAACGAGAAAAACAGCAAGCGCCGCGACCAAGACCCTCCCAG
CCGCCCCCGCCCCCTGTACCACACTTACAGCCCATGTCCCAAATCACAGGGTTGAAAAAG
TTGATGCATAGTAACAGCCTGAACAACTCTAACATTCCCCGATTTGGGGTGAAGACCGAT
CAAGAAGAGCTCCTGGCCCAAGAACTGGAGAACCTGAACAAGTGGGGCCTGAACATCTTT
TGCGTGTCGGATTACGCTGGAGGCCGCTCACTCACCTGCATCATGTACATGATATTCCAG
GAGCGGGACCTGCTGAAGAAATTCCGCATCCCGGTGGACACGATGGTGACATACATGCTG
ACGCTGGAGGATCACTACCACGCTGACGTGGCCTACCATAACAGCCTGCACGCAGCTGAC
GTGCTGCAGTCCACCCACGTACTGCTGGCCACGCCTGCACTAGATGCAGTGTTCACGGAC
CTGGAGATTCTCGCCGCCCTCTTCGCGGCTGCCATCCACGATGTGGATCACCCTGGGGTC
TCCAACCAGTTCCTCATCAACACCAATTCGGAGCTGGCGCTCATGTACAACGATGAGTCG
GTGCTCGAGAATCACCACCTGGCCGTGGGCTTCAAGCTGCTGCAGGAGGACAACTGCGAC
ATCTTCCAGAACCTCAGCAAGCGCCAGCGGCAGAGCCTACGCAAGATGGTCATCGACATG
GTGCTGGCCACGGACATGTCCAAGCACATGACCCTCCTGGCTGACCTGAAGACCATGGTG
GAGACCAAGAAAGTGACCAGCTCAGGGGTCCTCCTGCTAGATAACTACTCCGACCGCATC
CAGGTCCTCCGGAACATGGTGCACTGTGCCGACCTCAGCAACCCCACCAAGCCGCTGGAG
CTGTACCGCCAGTGGACAGACCGCATCATGGCCGAGTTCTTCCAGCAGGGTGACCGAGAG
CGCGAGCGTGGCATGGAAATCAGCCCCATGTGTGACAAGCACACTGCCTCCGTGGAGAAG
TCTCAGGTGGGTTTTATTGACTACATTGTGCACCCATTGTGGGAGACCTGGGCGGACCTT
GTCCACCCAGATGCCCAGGAGATCTTGGACACTTTGGAGGACAACCGGGACTGGTACTAC
AGCGCCATCCGGCAGAGCCCATCTCCGCCACCCGAGGAGGAGTCAAGGGGGCCAGGCCAC
CCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGAA
ATATCAATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCA
GGAGTCGAGGAAGCTCTGGATGCAACCATAGCCTGGGAGGCATCCCCGGCCCAGGAGTCG
TTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGACA
CAGCAGGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAG
GAATTCGTGGTTGCTGTAAGCCACAGCAGCCCCTCTGCCCTGGCTCTTCAAAGCCCCCTT
CTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCCC
TCCACGGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGT
GCCTGCGCAGGGACATTTGGGGAGGACACATCCGCACTCCCAGCTCCTGGTGGCGGGGGG
TCAGGTGGAGACCCTACCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
L20965

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_3_Locus:
19p13.2

# Metabolic_Enzyme_3_SNPs:
rs1051738; rs2230190; rs2230189; rs7256672; rs3745258; rs4804134; rs2358681; rs10416143; rs7247481; rs7343073; rs1194098; rs11672021; rs1051736; rs3192116; rs35473931; rs35610871; rs3745260; rs3192124; rs3833220; rs7253115; rs12985883; rs3745259; rs34212445; rs2569755; rs35371416; rs12983959; rs2569756; rs2735389; rs5827100; rs11666164; rs10404367; rs12975524; rs34214178; rs35888394; rs10411816; rs34675916; rs12610073; rs35398762; rs34222169; rs33984348; rs34278258; rs35452057; rs12975511; rs34861232; rs12981823; rs12982685; rs1194097; rs4804504; rs35757023; rs12982917; rs35214617; rs34230915; rs4804503; rs35368894; rs12981546; rs12975530; rs3936362; rs35867809; rs2735390; rs10423080; rs2569758; rs2569765; rs12978292; rs2569766; rs12978315; rs2569757; rs2569763; rs12978301; rs2569759; rs2569761; rs12978366; rs2569764; rs2569762; rs12978582; rs2569760; rs12980133; rs35084366; rs12980191; rs12981218; rs35715070; rs34519818; rs35937838; rs10416653; rs11671269; rs2569767; rs2569768; rs4804505; rs8105602

# Metabolic_Enzyme_3_General_References:
8413254; 9677330; 2160582; 7772058; 7888306

# Metabolic_Enzyme_3_References:
184855

# Metabolic_Enzyme_4_ID:
5630

# Metabolic_Enzyme_4_Name:
Membrane copper amine oxidase

# Metabolic_Enzyme_4_Synonyms:
Semicarbazide-sensitive amine oxidase; SSAO; Vascular adhesion protein 1; VAP-1; HPAO

# Metabolic_Enzyme_4_Gene_Name:
AOC3

# Metabolic_Enzyme_4_Protein_Sequence:
>Membrane copper amine oxidase
MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVW
AEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHP
RGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDF
SDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSA
DSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN

# Metabolic_Enzyme_4_Number_of_Residues:
763

# Metabolic_Enzyme_4_Molecular_Weight:
84623

# Metabolic_Enzyme_4_Theoretical_pI:
6.51

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_4_Specific_Function:
Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity

# Metabolic_Enzyme_4_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_4_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_4_Signals:
1-19

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_4_GenBank_ID_Protein:
1399032

# Metabolic_Enzyme_4_SwissProt_ID:
AOC3_HUMAN (Q16853)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
AOC3

# Metabolic_Enzyme_4_Geneatlas_id:
AOC3

# Metabolic_Enzyme_4_hgnc_id:
HGNC:550

# Metabolic_Enzyme_4_PDB_ID:
1PU4

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_4_Gene_Sequence:
>2292 bp
ATGAACCAGAAGACAATCCTCGTGCTCCTCATTCTGGCCGTCATCACCATCTTTGCCTTG
GTTTGTGTCCTGCTGGTGGGCAGGGGTGGAGATGGGGGTGAACCCAGCCAGCTTCCCCAT
TGCCCCTCTGTATCTCCCAGTGCCCAGCCTTGGACACACCCTGGCCAGAGCCAGCTGTTT
GCAGACCTGAGCCGAGAGGAGCTGACGGCTGTGATGCGCTTTCTGACCCAGCGGCTGGGG
CCAGGGCTGGTGGATGCAGCCCAGGCCCGGCCCTCGGACAACTGTGTCTTCTCAGTGGAG
TTGCAGCTGCCTCCCAAGGCTGCAGCCCTGGCTCACTTGGACAGGGGGAGCCCCCCACCT
GCCCGGGAGGCACTGGCCATCGTCTTCTTTGGCAGGCAACCCCAGCCCAACGTGAGTGAG
CTGGTGGTGGGGCCACTGCCTCACCCCTCCTACATGCGGGACGTGACTGTGGAGCGTCAT
GGAGGCCCCCTGCCCTATCACCGACGCCCCGTGCTGTTCCAAGAGTACCTGGACATAGAC
CAGATGATCTTCAACAGAGAGCTGCCCCAGGCTTCTGGGCTTCTCCACCACTGTTGCTTC
TACAAGCACCGGGGACGGAACCTGGTGACAATGACCACGGCTCCCCGTGGTCTGCAATCA
GGGGACCGGGCCACCTGGTTTGGCCTCTACTACAACATCTCGGGCGCTGGGTTCTTCCTG
CACCACGTGGGCTTGGAGCTGCTAGTGAACCACAAGGCCCTTGACCCTGCCCGCTGGACT
ATCCAGAAGGTGTTCTATCAAGGCCGCTACTACGACAGCCTGGCCCAGCTGGAGGCCCAG
TTTGAGGCCGGCCTGGTGAATGTGGTGCTGATCCCAGACAATGGCACAGGTGGGTCCTGG
TCCCTGAAGTCCCCTGTGCCCCCGGGTCCAGCTCCCCCTCTACAGTTCTATCCCCAAGGC
CCCCGCTTCAGTGTCCAGGGAAGTCGAGTGGCCTCCTCACTGTGGACTTTCTCCTTTGGC
CTCGGAGCATTCAGTGGCCCAAGGATCTTTGACGTTCGCTTCCAAGGAGAAAGACTAGTT
TATGAGATAAGCCTCCAAGAGGCCTTGGCCATCTATGGTGGAAATTCCCCAGCAGCAATG
ACGACCCGCTATGTGGATGGAGGCTTTGGCATGGGCAAGTACACCACGCCCCTGACCCGT
GGGGTGGACTGCCCCTACTTGGCCACCTACGTGGACTGGCACTTCCTTTTGGAGTCCCAG
GCCCCCAAGACAATACGTGATGCCTTTTGTGTGTTTGAACAGAACCAGGGCCTCCCCCTG
CGGCGACACCACTCAGATCTCTACTCGCACTACTTTGGGGGTCTTGCGGAAACGGTGCTG
GTCGTCAGATCTATGTCCACCTTGCTCAACTATGACTATGTGTGGGATACGGTCTTCCAC
CCCAGTGGGGCCATAGAAATACGATTCTATGCCACGGGCTACATCAGCTCGGCATTCCTC
TTTGGTGCTACTGGGAAGTACGGGAACCAAGTGTCAGAGCACACCCTGGGCACGGTCCAC
ACCCACAGCGCCCACTTCAAGGTGGATCTGGATGTAGCAGGACTGGAGAACTGGGTCTGG
GCCGAGGATATGGTCTTTGTCCCCATGGCTGTGCCCTGGAGCCCTGAGCACCAGCTGCAG
AGGCTGCAGGTGACCCGGAAGCTGCTGGAGATGGAGGAGCAGGCCGCCTTCCTCGTGGGA
AGCGCCACCCCTCGCTACCTGTACCTGGCCAGCAACCACAGCAACAAGTGGGGTCACCCC
CGGGGCTACCGCATCCAGATGCTCAGCTTTGCTGGAGAGCCGCTGCCCCAAAACAGCTCC
ATGGCGAGAGGCTTCAGCTGGGAGAGGTACCAGCTGGCTGTGACCCAGCGGAAGGAGGAG
GAGCCCAGTAGCAGCAGCGTTTTCAATCAGAATGACCCTTGGGCCCCCACTGTGGATTTC
AGTGACTTCATCAACAATGAGACCATTGCTGGAAAGGATTTGGTGGCCTGGGTGACAGCT
GGTTTTCTGCATATCCCACATGCAGAGGACATTCCTAACACAGTGACTGTGGGGAACGGC
GTGGGCTTCTTCCTCCGACCCTATAACTTCTTTGACGAAGACCCCTCCTTCTACTCTGCC
GACTCCATCTACTTCCGAGGGGACCAGGATGCTGGGGCCTGCGAGGTCAACCCCCTAGCT
TGCCTGCCCCAGGCTGCTGCCTGTGCCCCCGACCTCCCTGCCTTCTCCCACGGGGGCTTC
TCTCACAACTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
U39447

# Metabolic_Enzyme_4_Chromosome_Location:
Not Available

# Metabolic_Enzyme_4_Locus:
Not Available

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
8972912; 9653080

# Metabolic_Enzyme_4_References:
6408912; 6805264

# Macromolecular_Interacting_Partner_1_ID:
7860

# Macromolecular_Interacting_Partner_1_Name:
Myoglobin

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
MB

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Myoglobin
MGLSDGEWQLVLNVWGKVEADIPGHGQEVLIRLFKGHPETLEKFDKFKHLKSEDEMKASE
DLKKHGATVLTALGGILKKKGHHEAEIKPLAQSHATKHKIPVKYLEFISECIIQVLQSKH
PGDFGADAQGAMNKALELFRKDMASNYKELGFQG

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
154

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
17184

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.86

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  oxygen binding
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
 ||
>>>
Process:  gas transport
Process:  oxygen transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00042:Globin

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
1235527

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
MYG_HUMAN (P02144)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
MB

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
MB

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6915

# Macromolecular_Interacting_Partner_1_PDB_ID:
2MM1

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>95 bp
ATGGGGCTCAGCGACGGGGAATGGCAGTTGGTGCTGAACGTCTGGGGGAAGGTGGAGGCT
GACATCCCAGGCCATGGGCAGGAAGTCCTCATCAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
X00371

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_1_Locus:
22q13.1

# Macromolecular_Interacting_Partner_1_SNPs:
rs7292; rs7293; rs1056680; rs1997882; rs8136856; rs5750136; rs5750135; rs8140955; rs8140917; rs8140868; rs8140953; rs8141044; rs8137205; rs8141731; rs8141728; rs8141048; rs8140754; rs2899254; rs916230; rs2076141; rs5755790; rs5755791; rs5750130; rs5750132; rs5755794; rs16995880; rs5755799; rs2179870; rs2283962; rs5755795; rs5755797; rs5755793; rs762911; rs5750133; rs5755798; rs5755789; rs17722766; rs2283963; rs5999890; rs5750131; rs5755796; rs5750134; rs16995883; rs17795829; rs4821424; rs5995129; rs5755788; rs4140603; rs4820205; rs4140604; rs4821423; rs3788512; rs16995876; rs5755800; rs35469011; rs35479350; rs13056550; rs13056588; rs28564512; rs35884692; rs8136969; rs13056581; rs5999892; rs5995128; rs13056580; rs17722736; rs1076908; rs35141221; rs34697597; rs35171458; rs1076909; rs11705485; rs5755792; rs8137225; rs34126675; rs5750137; rs7292530; rs34893226; rs1012901; rs11912845; rs1476000; rs17842411; rs4497964; rs4622835; rs4821419; rs4821420; rs4821421; rs4821422; rs5750124; rs5750125; rs5750126; rs5755781; rs5999885; rs5999888; rs5999894; rs9607278

# Macromolecular_Interacting_Partner_1_General_References:
6571704; 2989088; 10591208; 5285572; 4627044; 7895732; 5805522; 5555219; 5555226; 5540041; 2342104

# Macromolecular_Interacting_Partner_1_References:
14582982; 15740057

End of HMDB00194

Beginning of HMDB00195
# Accession_No:
HMDB00195

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-22 16:55:03

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Inosine

# Description:
A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)

# Synonyms:
(-)-Inosine; 1,9-Dihydro-9-beta-D-ribofuranosyl-6H-purin-6-one; 1,9-dihydro-9-b-D-ribofuranosyl-6H-Purin-6-one; 9-b-D-Ribofuranosylhypoxanthine; 9-b-D-ribofuranosyl-Hypoxanthine; 9-beta-D-Ribofuranosylhypoxanthine; 9-beta-D-ribofuranosyl-Hypoxanthine; 9beta-D-Ribofuranosylhypoxanthine; Atorel; HXR; Hypoxanthine 9-beta-D-ribofuranoside; Hypoxanthine D-riboside; Hypoxanthine nucleoside; Hypoxanthine ribonucleoside; Hypoxanthine riboside; Hypoxanthine-9-D-ribofuranoside; Hypoxanthine-9-beta-D-ribofuranoside; Hypoxanthosine; Indole-3-carboxaldehyde; Ino; Inosie; Oxiamin; Panholic-L; Pantholic-L; Ribonosine; Selfer; Trophicardyl; beta-D-Ribofuranoside hypoxanthine-9; beta-Inosine; hypoxanthine-9 beta-D-Ribofuranoside; hypoxanthine-ribose; iso-prinosine; 1,9-Dihydro-9-beta-delta-ribofuranosyl-6H-purin-6-one; 9-beta-delta-Ribofuranosylhypoxanthine; 9-beta-delta-ribofuranosyl-Hypoxanthine; 9beta-delta-Ribofuranosylhypoxanthine; Hypoxanthine 9-beta-delta-ribofuranoside; Hypoxanthine-9-delta-ribofuranoside; Hypoxanthine-9-beta-delta-ribofuranoside; beta-delta-Ribofuranoside hypoxanthine-9; hypoxanthine-9 beta-delta-Ribofuranoside

# Chemical_IUPAC_Name:
9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one

# Chemical_Formula:
C10H12N4O5

# Chemical_Structure:
tbl_chemical:::HMDB00195_ZOOM.png:::119283246860913549

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00195_THUMB.png:::119283246657877437

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; primary alcohol; secondary alcohol; 1,2-diol; oxo(het)arene; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of Purine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
268.08078

# Molecular_Weight_Avg:
268.22607

# Smiles_String_isomeric:
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=NC3=C2N=CN=C3O

# Smiles_String_canonical:
OCC1OC(C(O)C1O)N2C=NC3=C2N=CN=C3O

# KEGG_Compound_ID:
C00294

# BioCyc_ID:
INOSINE

# PubChem_CID:
6021

# PubChem_SID:
819072; 10528369; 8139984; 603219; 10318627; 829760; 7889457; 11378263; 11373131; 11375692; 855079; 12789588; 11364968; 148876; 841594; 12090925; 7847122; 3133546; 11367530; 824370; 11370092; 3588; 831627; 8144594; 8027801

# OMIM_ID:
164050

# Metagene_ID:
PURINE NUCLEOSIDE PHOSPHORYLASE DIFICIENCY: 403

# BiGG_ID:
34525

# Wikipedia_ID:
Inosine

# METLIN_ID:
84

# Ref_ID:
7090336; 7614924; 6681617; 15976325; 9663253; 10499868; 15493114; 15882454; 8241644; 10917906; 8595732; 8597780; 12865945; 11912550; 6656991; 3698269; 9607216; 12451183; 3981053

# ChEBI_ID:
17596

# CAS_Registry_Number:
58-63-9

# InChI:
InChI=1/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10-/m1/s1

# Synthesis_Reference:
Kinichi, I. et al., Chem. Pharm. Bull., 1966, 14, 1377

# Melting_Point:
218 oC

# Melting_Point_predicted:
141.3 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
15.8 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]; 35 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
27.6 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-2.10 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-1.20 [Predicted by ALOGPS]; -1.6 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Inosine.pdf:::1132562214860558730

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Inosine.mol:::1132723813312762255

# SDF_File_[Text]:
tbl_chemical:::HMDB00195.sdf:::119283246221493613

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00195.pdb:::119283246497991470

# PDB_ID:
1A9S

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041005_P00_01_HW_1DP_PRESAT_expanded_2.gif:::114460751623845034

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041005_P00_01_HW_1DP_presat.zip:::1177710559642909257

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041005_P00_01_HW_1DP_Assigned.png:::117821907819098750

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041005_P00_01_HW_2DHSQC_734.png:::114790131258951010

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041005_P00_01_HW_2DHSQC_734.zip:::114790131259379956

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041005_P00_01_HW_2DHSQC_734_Assigned.png:::116284892389297148

# Predicted_H_NMR_Spectrum:
tbl_chemical:::inosine.gif:::113273212101569035

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00195_peaks.txt:::1156309611459977863

# Predicted_C_NMR_Spectrum:
tbl_chemical:::inosine_C.gif:::1132737719747346668

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00195_peaks.txt:::1156310800741860193

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00195L.png:::117555262292384666; Medium Energy:tbl_ms:::HMDB00195M.png:::117555267573069100; High Energy:tbl_ms:::HMDB00195H.png:::117555271237976367

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000098.png:::116899931260946242

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000098.txt:::116899931260911082

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000098.png:::11689082681256303

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000098.txt:::116890826839043742

# Cellular_Location:
Cytoplasm; Extracellular; lysosome; mitochondria

# Tissue_Location:
Brain; Erythrocyte; Fibroblasts; Intestine; Kidney; Nerves; Pancreas; Placenta; Platelet; Spleen; Testes

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Cellular Cytoplasm; Pericardial Effusion

# Concentration_[Normal]:
Blood	0.6 +/- 0.45	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	0.05 +/- 0.01	uM	Adult:>18_yrs_old	Both	Normal	9663253
Blood	0.8	uM	Adult:>18_yrs_old	Both	Normal	3981053
Blood	5.0 +/- 0.8	uM	Adult:>18_yrs_old	Both	Normal	9607216
Blood	0.1	umol/L	Adult:>18_yrs_old	Both	Normal	6656991
Cerebrospinal_Fluid(CSF)	0.64 +/- 0.35	uM	Adult:>18_yrs_old	Both	Normal	8597780
Cerebrospinal_Fluid(CSF)	0.6 (0.0-1.2)	uM	Newborn:0-30_days_old	Both	Normal	6681617
Pericardial_Effusion	0.347 (0.159 - 1.037)	uM	Adult:>18_yrs_old	Both	Normal	10499868
Cellular_Cytoplasm	1	umol/L	Adult:>18_yrs_old	Both	Normal	15882454


# Concentration_[Abnormal]:
Blood	0.13 +/- 0.10	uM	Adult:>18_yrs_old	Both	Acute and severe illness	9663253
Cerebrospinal_Fluid(CSF)	0.70 (0.60-0.80)	umol/L	Adult:>18_yrs_old	Both	Degenerative disc disease	6656991
Pericardial_Effusion	0.658 (0.321 - 1.331)	uM	Adult:>18_yrs_old	Both	Coronary Artery Disease	10499868


# Associated_Disorders:
Acute and severe illness; Coronary Artery Disease; Degenerative disc disease; Purine Nucleoside Phosphorylase Deficiency

# Pathway_Names:
Purine metabolism;Nicotinate and nicotinamide metabolism

# Pathway_Images:
Purine_Synthesis.jpg;Nicotinamide_synthesis_(NADH).jpg

# KEGG_Images:
map00230;map00760

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;Nicotinamide_synthesis_(NADH)_Graph.jpg

# Pathway_SBMLs:
Purine_Synthesis.xml;Nicotinamide_synthesis_(NADH).xml

# Metabolic_Enzyme_1_ID:
5236

# Metabolic_Enzyme_1_Name:
5'(3')-deoxyribonucleotidase, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
5',3'-nucleotidase, mitochondrial; Deoxy-5'-nucleotidase 2; dNT-2

# Metabolic_Enzyme_1_Gene_Name:
NT5M

# Metabolic_Enzyme_1_Protein_Sequence:
>5'3'deoxyribonucleotidase, mitochondrial precursor
MIRLGGWCARRLCSAAVPAGRRGAAGGLGLAGGRALRVLVDMDGVLADFEGGFLRKFRAR
FPDQPFIALEDRRGFWVSEQYGRLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMAS
LQNTDVFICTSPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDI
TGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRPC

# Metabolic_Enzyme_1_Number_of_Residues:
228

# Metabolic_Enzyme_1_Molecular_Weight:
25862

# Metabolic_Enzyme_1_Theoretical_pI:
8.12

# Metabolic_Enzyme_1_GO_Classification:
Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP

# Metabolic_Enzyme_1_Pathway:
Not Available

# Metabolic_Enzyme_1_Reaction:
Not Available

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_1_Signals:
1-15

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
9408106

# Metabolic_Enzyme_1_SwissProt_ID:
NT5M_HUMAN (Q9NPB1)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
NT5M

# Metabolic_Enzyme_1_Geneatlas_id:
NT5M

# Metabolic_Enzyme_1_hgnc_id:
HGNC:15769

# Metabolic_Enzyme_1_PDB_ID:
1Q92

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_1_Gene_Sequence:
>687 bp
ATGATCCGGCTGGGCGGCTGGTGTGCGCGGCGGCTCTGCAGCGCGGCGGTTCCCGCGGGG
CGGCGCGGGGCGGCGGGCGGGCTGGGCCTGGCGGGAGGCCGCGCCCTACGGGTGCTGGTG
GACATGGACGGCGTGCTGGCTGACTTCGAGGGCGGATTCCTCAGGAAGTTCCGCGCGCGC
TTTCCCGACCAGCCCTTCATCGCGCTGGAGGACCGGCGCGGCTTCTGGGTGTCGGAGCAG
TACGGCCGCCTGCGGCCAGGGCTGAGCGAGAAGGCCATCAGCATTTGGGAGTCAAAGAAT
TTCTTTTTTGAACTTGAGCCTCTGCCAGGGGCCGTGGAAGCTGTCAAGGAGATGGCCAGC
CTACAAAACACTGACGTCTTCATCTGCACAAGCCCCATCAAGATGTTCAAGTACTGTCCC
TATGAGAAGTATGCCTGGGTGGAGAAGTACTTTGGCCCTGACTTTCTGGAGCAGATTGTG
CTGACCAGAGACAAGACCGTGGTCTCTGCTGACCTTCTCATAGACGACCGGCCGGACATC
ACAGGGGCCGAGCCAACCCCCAGCTGGGAGCATGTCCTCTTCACCGCCTGCCACAACCAG
CACCTGCAGCTGCAGCCCCCCCGCCGCAGGCTGCACTCGTGGGCGGACGACTGGAAGGCC
ATTCTGGACAGCAAGCGGCCCTGCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AJ277557

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_1_Locus:
17p11.2

# Metabolic_Enzyme_1_SNPs:
rs2240876; rs758742; rs1860553; rs242243; rs6502579; rs7223473; rs11078384; rs7226068; rs10468464; rs12948296; rs1860552; rs9912109; rs9898622; rs7211968; rs17726703; rs9914692; rs3785502; rs11867932; rs3785504; rs17726673; rs11654778; rs16942153; rs17726858; rs11078382; rs3826302; rs2064060; rs6502580; rs7217503; rs9912172; rs3785506; rs9908168; rs11652902; rs9902505; rs4985707; rs6502576; rs6502578; rs16961564; rs7210344; rs16961516; rs242242; rs171394; rs12600778; rs9909111; rs7219752; rs6502577; rs12601631; rs11869054; rs17726924; rs9891799; rs11870836; rs11869507; rs11078383; rs4985706; rs7217162; rs9889738; rs9908338; rs7222555; rs9915883; rs7211243; rs9916133; rs9907857; rs9905836; rs11657817; rs9889298; rs7220829; rs9903425; rs9908360; rs9914424; rs9908124; rs11650700; rs11869079; rs7212369; rs9889367; rs7217114; rs9896977; rs9916676; rs16961561; rs12602026; rs9896970; rs9904396; rs9909850; rs10852849; rs11078385; rs6502575; rs242244; rs16961576; rs3203918; rs8082383; rs7212012; rs36114962; rs9889834; rs7226045; rs12602003; rs9894669; rs35712658; rs12941075; rs7210625; rs35320589; rs11655849; rs35470335; rs34668117; rs12943271; rs34446504; rs35945070; rs34219219; rs12951176; rs35554631; rs34408375; rs28825184; rs7218566; rs35917484; rs28880443; rs9904393; rs12601106; rs34579357; rs4985765; rs9907711; rs11343472; rs35579933; rs3087093; rs12951985; rs34993127; rs36088408; rs36091965; rs34100977; rs7220057; rs8080335; rs9901325; rs35720826; rs34886391; rs12949216; rs9898993; rs34121330; rs34513135; rs12936127; rs8067236; rs8081939; rs10617184; rs7211790; rs9914209; rs12951519; rs12603230; rs9913775; rs8068408; rs12452455; rs9901373; rs3063349; rs9913682; rs3785503; rs34156759; rs34776810; rs10574223; rs34836173; rs12951434; rs9709057; rs28813401; rs36146846; rs34709982; rs28616155; rs8082379; rs35267848; rs12951289; rs12948357; rs12950577; rs35861887; rs12948747; rs35096596; rs8080408; rs9898042; rs35930947; rs12948751; rs5741757; rs9889355; rs35575792; rs34018072; rs34407368; rs4985764; rs11395505; rs34676851; rs12951504; rs12950929; rs34025151; rs3837806; rs34247865; rs12946386; rs34209605; rs7219953; rs12951983; rs11400183; rs9912599; rs36056059; rs8071972; rs35039203; rs35326975; rs8071718; rs12946113; rs1009720; rs10852850; rs11078381; rs11078386; rs11871699; rs12450758; rs12451886; rs12452946; rs12602578; rs16961593; rs16961599; rs17648393; rs183596; rs190261; rs2041393; rs2058292; rs2191383; rs242246; rs242247; rs242249; rs242250; rs242251; rs624242; rs6502572; rs8067390; rs9892592; rs9899615; rs9905458; rs9909800; rs9914113

# Metabolic_Enzyme_1_General_References:
10899995; 12352955

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5237

# Metabolic_Enzyme_2_Name:
Cytosolic purine 5'-nucleotidase

# Metabolic_Enzyme_2_Synonyms:
5'-nucleotidase cytosolic II

# Metabolic_Enzyme_2_Gene_Name:
NT5C2

# Metabolic_Enzyme_2_Protein_Sequence:
>Cytosolic purine 5'nucleotidase
MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVY
KSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLV
CAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTS
CETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMK
EVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGT
VLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKS
KKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQ
RRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAA
HVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLA
PQEITHCHDEDDDEEEEEEEE

# Metabolic_Enzyme_2_Number_of_Residues:
561

# Metabolic_Enzyme_2_Molecular_Weight:
64970

# Metabolic_Enzyme_2_Theoretical_pI:
6.05

# Metabolic_Enzyme_2_GO_Classification:
Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides

# Metabolic_Enzyme_2_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_2_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF05761:5_nucleotid

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
633071

# Metabolic_Enzyme_2_SwissProt_ID:
5NTC_HUMAN (P49902)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
NT5C2

# Metabolic_Enzyme_2_Geneatlas_id:
NT5C2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:8022

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1686 bp
ATGTCGACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGAT
AAGCATGCCCTGAAAAAGTATCGTCGAGAAGCCTATCATCGGGTGTTTGTGAACCGAAGT
TTAGCAATGGAAAAGATAAAGTGTTTTGGTTTTGATATGGATTATACCCTTGCTGTGTAC
AAGTCCCCAGAGTATGAGTCCCTTGGTTTTGAGCTTACTGTGGAGAGATTAGTTTCTATT
GGCTATCCCCAGGAGTTGCTCAGCTTTGCTTATGATTCTACATTCCCTACCAGGGGACTT
GTCTTTGACACACTGTATGGAAATCTTTTGAAAGTCGATGCCTATGGAAACCTCTTGGTC
TGTGCACATGGATTTAACTTTATAAGGGGACCAGAAACTAGAGAACAGTATCCAAATAAA
TTTATCCAGCGAGATGATACTGAAAGATTTTACATTCTGAACACACTATTCAACCTACCA
GAGACCTACCTGTTGGCCTGCCTAGTAGATTTTTTTACTAATTGTCCCAGATATACCAGT
TGTGAAACAGGATTTAAAGATGGGGACCTCTTCATGTCCTACCGGAGTATGTTCCAGGAT
GTAAGAGATGCTGTTGACTGGGTTCATTACAAGGGCTCCCTTAAGGAAAAGACAGTTGAA
AATCTTGAGAAGTATGTAGTCAAAGATGGAAAACTGCCTTTGCTTCTGAGCCGGATGAAG
GAAGTAGGGAAAGTATTTCTTGCTACCAACAGTGACTATAAATATACAGATAAAATTATG
ACTTACCTGTTTGACTTCCCACATGGCCCCAAGCCTGGGAGCTCCCATCGACCATGGCAG
TCCTACTTTGACTTGATCTTGGTGGATGCACGGAAACCACTCTTTTTTGGAGAAGGCACA
GTACTGCGTCAGGTGGATACTAAAACTGGCAAGCTGAAAATTGGTACCTACACAGGGCCC
CTACAGCATGGTATCGTCTACTCAGGAGGTTCTTCTGATACGATCTGTGACCTGTTGGGA
GCCAAGGGAAAAGACATTTTGTATATTGGAGATCACATTTTTGGGGACATTTTAAAATCA
AAGAAACGGCAAGGGTGGCGAACTTTTTTGGTGATTCCTGAACTCGCACAGGAGCTACAT
GTCTGGACTGACAAGAGTTCACTTTTCGAAGAACTTCAGAGCTTGGATATTTTCTTGGCT
GAACTCTACAAGCATCTTGACAGCAGTAGCAATGAGCGTCCAGACATCAGTTCCATCCAG
AGACGTATTAAGAAAGTAACTCATGACATGGACATGTGCTATGGGATGATGGGAAGCCTG
TTTCGCAGTGGCTCCCGGCAGACCCTTTTTGCCAGTCAAGTGATGCGTTATGCTGACCTC
TATGCAGCATCTTTCATCAACCTGCTGTATTACCCTTTCAGCTACCTCTTCAGGGCTGCC
CATGTCTTGATGCCTCATGAATCAACGGTGGAGCACACACACGTAGATATCAATGAGATG
GAGTCTCCTCTTGCCACCCGGAACCGCACATCAGTGGATTTCAAAGACACTGACTACAAG
CGGCACCAGCTGACACGGTCAATTAGTGAGATTAAACCTCCCAACCTCTTCCCACTGGCC
CCCCAGGAAATTACACACTGCCATGACGAAGATGATGATGAAGAGGAGGAGGAGGAGGAA
GAATAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
D38524

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_2_Locus:
10q24.32-q24.33

# Metabolic_Enzyme_2_SNPs:
rs12262171; rs3740387; rs12253627; rs10786736; rs8139; rs7917650; rs10786741; rs7920251; rs10430665; rs7916854; rs12573199; rs11191598; rs1163238; rs12573200; rs10883843; rs7092407; rs12573221; rs4917997; rs11191593; rs11191596; rs10786744; rs1163236; rs10883842; rs10786742; rs10786743; rs7075552; rs7077097; rs2863728; rs3758543; rs7077291; rs10748838; rs3087681; rs12240508; rs732998; rs10883830; rs7899084; rs2274340; rs2182348; rs2066322; rs7908960; rs7912517; rs7067970; rs3740386; rs7896547; rs11191554; rs1163249; rs2281877; rs2863727; rs3781281; rs2274341; rs2148198; rs7897663; rs3781282; rs10883832; rs1926029; rs1935323; rs1926030; rs746293; rs6584539; rs2066323; rs9919482; rs3740385; rs12773916; rs12414232; rs10786737; rs12413046; rs12412038; rs2274339; rs11598702; rs1541213; rs11191580; rs11191553; rs10509765; rs10509766; rs3977751; rs12220375; rs4917996; rs7896433; rs6584540; rs1926037; rs3736922; rs11191577; rs2148197; rs11191561; rs7080935; rs11191555; rs10883833; rs12219304; rs1926036; rs7913920; rs10883834; rs11191558; rs11191582; rs11191589; rs10883831; rs12220743; rs10786738; rs11191560; rs10748837; rs11191578; rs3781280; rs7896519; rs12217501; rs11191573; rs7067741; rs6584541; rs7067663; rs2148200; rs10883840; rs11191583; rs12415199; rs9919485; rs11191557; rs17094683; rs7895154; rs12355120; rs2153774; rs10786739; rs7915816; rs7081075; rs1807298; rs3861984; rs11191572; rs12571568; rs12416331; rs11191586; rs10883839; rs12766205; rs1163239; rs10883837; rs11191584; rs1163247; rs17115452; rs11191556; rs7909022; rs12775302; rs9633712; rs11191581; rs11191576; rs10883836; rs11191549; rs7095304; rs10883845; rs11191550; rs11191548; rs11191602; rs10748839; rs1141101; rs1055812; rs1141100; rs1141098; rs1141099; rs34351688; rs34394526; rs34058246; rs11191594; rs35224704; rs34747231; rs12774207; rs11191595; rs34699185; rs11280184; rs1163237; rs7073259; rs34064597; rs11191601; rs35525740; rs35291480; rs12264098; rs35978588; rs12241986; rs7091462; rs12774182; rs34756486; rs35695488; rs12252236; rs3834416; rs11191600; rs34136949; rs7080242; rs12763243; rs34003851; rs11191585; rs11191551; rs36111455; rs34966121; rs35464534; rs35541240; rs11191571; rs35913488; rs34223002; rs11440429; rs41287482; rs35653865; rs34963818; rs11191559; rs11191568; rs35436872; rs17795366; rs1163246; rs34060908; rs34963563; rs34915846; rs12780509; rs2153773; rs34211645; rs3736924; rs34758128; rs36059537; rs35302704; rs12255989; rs34104646; rs11191574; rs11191564; rs35745742; rs34644789; rs5787481; rs34863357; rs11191590; rs12774840; rs2148196; rs12763944; rs3215816; rs34207290; rs35752695; rs34445719; rs28419708; rs4421684; rs28516969; rs12265498; rs12767422; rs12772228; rs34908445; rs11191570; rs17115449; rs35195396; rs12243923; rs10883835; rs12779263; rs11302933; rs7091173; rs11375439; rs7071103; rs35146429; rs35338839; rs34268365; rs34130454; rs35898850; rs3861983; rs28404041; rs35621207; rs3736923; rs5787482; rs7075048; rs34307431; rs35348020; rs34349473; rs1773930; rs11191566; rs34870452; rs35078544; rs35123178; rs12265545; rs1163241; rs3949893; rs7904067; rs12775841; rs35821867; rs12775904; rs7915032; rs5028036; rs35254502; rs1163248; rs35365027; rs34876862; rs11191565; rs12772280; rs10709724; rs35085852; rs35351555; rs12774513; rs10710371; rs11296588; rs12243903; rs28605898; rs34241930; rs34549427; rs11451961; rs34403968; rs12761657; rs34397864; rs3062737; rs36092020; rs35109679; rs34011916; rs34435560; rs11191562; rs4917383; rs34067380; rs34202831; rs11191563; rs2148199; rs34133379; rs35763505; rs12414385; rs1163240; rs12262258; rs11191588; rs34664715; rs12414374; rs35133717; rs3837340; rs10614009; rs2153772; rs11191587; rs11403586; rs11191575; rs1060240; rs34588165; rs11191552; rs41317254; rs1163245; rs1064099; rs12268552; rs34833988; rs11191603; rs12253716; rs12412924; rs3841710; rs34551510; rs12246784; rs12781668; rs1064098; rs10458729; rs10786740; rs10786745; rs10883829; rs10883841; rs11191547; rs1163235; rs12261294; rs12571345; rs12785223; rs17115427; rs4307650; rs4917382; rs4917995; rs7074395; rs7092200; rs726010; rs763914; rs7921996; rs943035

# Metabolic_Enzyme_2_General_References:
7999131

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5937

# Metabolic_Enzyme_3_Name:
Adenosine deaminase

# Metabolic_Enzyme_3_Synonyms:
Adenosine aminohydrolase

# Metabolic_Enzyme_3_Gene_Name:
ADA

# Metabolic_Enzyme_3_Protein_Sequence:
>Adenosine deaminase
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL

# Metabolic_Enzyme_3_Number_of_Residues:
363

# Metabolic_Enzyme_3_Molecular_Weight:
40765

# Metabolic_Enzyme_3_Theoretical_pI:
5.80

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  adenosine deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_3_Specific_Function:
Adenosine + H(2)O = inosine + NH(3)

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_3_Reaction:
adenosine + H2O = inosine + ammonia

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.5.4.4

# Metabolic_Enzyme_3_GenBank_ID_Protein:
28380

# Metabolic_Enzyme_3_SwissProt_ID:
ADA_HUMAN (P00813)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ADA

# Metabolic_Enzyme_3_Geneatlas_id:
ADA

# Metabolic_Enzyme_3_hgnc_id:
HGNC:186

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_3_Gene_Sequence:
>1092 bp
ATGGCCCAGACGCCCGCCTTCGACAAGCCCAAAGTAGAACTGCATGTCCACCTAGACGGA
TCCATCAAGCCTGAAACCATCTTATACTATGGCAGGAGGAGAGGGATCGCCCTCCCAGCT
AACACAGCAGAGGGGCTGCTGAACGTCATTGGCATGGACAAGCCGCTCACCCTTCCAGAC
TTCCTGGCCAAGTTTGACTACTACATGCCTGCTATCGCGGGCTGCCGGGAGGCTATCAAA
AGGATCGCCTATGAGTTTGTAGAGATGAAGGCCAAAGAGGGCGTGGTGTATGTGGAGGTG
CGGTACAGTCCGCACCTGCTGGCCAACTCCAAAGTGGAGCCAATCCCCTGGAACCAGGCT
GAAGGGGACCTCACCCCAGACGAGGTGGTGGCCCTAGTGGGCCAGGGCCTGCAGGAGGGG
GAGCGAGACTTCGGGGTCAAGGCCCGGTCCATCCTGTGCTGCATGCGCCACCAGCCCAAC
TGGTCCCCCAAGGTGGTGGAGCTGTGTAAGAAGTACCAGCAGCAGACCGTGGTGGCCATT
GACCTGGCTGGAGATGAGACCATCCCAGGAAGCAGCCTCTTGCCTGGACATGTCCAGGCC
TACCAGGAGGCTGTGAAGAGCGGCATTCACCGTACTGTCCACGCCGGGGAGGTGGGCTCG
GCCGAAGTAGTAAAAGAGGCTGTGGACATACTCAAGACAGAGCGGCTGGGACACGGCTAC
CACACCCTGGAAGACCAGGCCCTTTATAACAGGCTGCGGCAGGAAAACATGCACTTCGAG
ATCTGCCCCTGGTCCAGCTACCTCACTGGTGCCTGGAAGCCGGACACGGAGCATGCAGTC
ATTCGGCTCAAAAATGACCAGGCTAACTACTCGCTCAACACAGATGACCCGCTCATCTTC
AAGTCCACCCTGGACACTGATTACCAGATGACCAAACGGGACATGGGCTTTACTGAAGAG
GAGTTTAAAAGGCTGAACATCAATGCGGCCAAATCTAGTTTCCTCCCAGAAGATGAAAAG
AGGGAGCTTCTCGACCTGCTCTATAAAGCCTATGGGATGCCACCTTCAGCCTCTGCAGGG
CAGAACCTCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X02994

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_3_Locus:
20q12-q13.11

# Metabolic_Enzyme_3_SNPs:
rs244076; rs11906526; rs427224; rs244078; rs2299686; rs2224999; rs379863; rs8119702; rs8119756; rs244075; rs2299691; rs2007515; rs2057637; rs762539; rs447833; rs2057638; rs6031682; rs6031690; rs6031686; rs2299688; rs6031689; rs371927; rs244079; rs2007720; rs1799880; rs2299692; rs395209; rs399159; rs2299690; rs11700291; rs929089; rs406383; rs2057639; rs967807; rs244073; rs2299694; rs452159; rs2157436; rs6031693; rs2299687; rs6017375; rs446125; rs2477898; rs6103795; rs6017378; rs445170; rs6031685; rs765215; rs6031695; rs1810751; rs2299697; rs433875; rs6031688; rs6094011; rs765216; rs244072; rs6031687; rs2299689; rs427483; rs427499; rs11907906; rs12480490; rs6103803; rs6031697; rs6017371; rs6031678; rs375379; rs384851; rs395896; rs450043; rs6094005; rs6031679; rs11698539; rs389308; rs11086932; rs6103804; rs6065738; rs1042360; rs11555566; rs7344760; rs6031698; rs394105; rs36216718; rs5841559; rs34853885; rs6017373; rs34665505; rs2765290; rs3831638; rs35553416; rs2515692; rs6031694; rs6103801; rs6103792; rs36222732; rs10561362; rs6103799; rs35009045; rs6094008; rs2007704; rs11474041; rs6103794; rs445725; rs11905649; rs6017376; rs457669; rs35383274; rs6103796; rs368253; rs6130653; rs6031691; rs11468750; rs8118045; rs6094004; rs455368; rs11484279; rs6031696; rs912912; rs6103800; rs6031684; rs445856; rs6094007; rs6017377; rs755144; rs6094009; rs11481765; rs382464; rs6103789; rs35712615; rs404898; rs6124654; rs929088; rs6031692; rs35863085; rs414146; rs6031681; rs413816; rs6103790; rs6031683; rs35436165; rs35935728; rs11698497; rs11373171; rs3091476; rs36013790; rs5841560; rs11907079; rs6103793; rs34344438; rs6017374; rs34081313; rs35535317; rs6130651; rs7353732; rs11484329; rs3041775; rs451499; rs3787359; rs11476459; rs7262528; rs6103797; rs34225524; rs11480982; rs34830340; rs6094010; rs6094006; rs3787360; rs6073497; rs11473840; rs13036408; rs34044957; rs244074; rs6103788; rs6017372; rs386512; rs35483396; rs11468701; rs2299695; rs244077; rs35505353; rs36102321; rs35545345; rs6103802; rs6103791; rs6103798; rs3831639; rs34833873; rs35784536; rs35587028; rs420183; rs6130652; rs10645831; rs36216716; rs435679; rs36216717; rs6031700; rs35153391; rs1061662; rs11699718; rs1886849; rs2071878; rs2148040; rs244081; rs244082; rs244086; rs244087; rs2664524; rs2664557; rs2664560; rs2664582; rs2664585; rs2868116; rs3180636; rs4810427; rs4810428; rs6017369; rs6031673; rs6031674; rs6031675; rs6031676; rs6031677; rs6031702; rs6031704; rs6065739; rs6094001; rs6094002; rs6094003; rs6094016; rs6094017; rs6103786; rs6103787; rs6103805; rs6103806; rs6130650; rs6130654; rs7266968; rs8118020; rs927784

# Metabolic_Enzyme_3_General_References:
6090454; 6546794; 3839456; 3028473; 11780052; 6688808; 8031011; 6208479; 3839802; 3182793; 2783588; 1284479; 8227344; 8299233; 8589684; 7599635; 9225964

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5232

# Metabolic_Enzyme_4_Name:
Cytosolic 5'-nucleotidase 1B

# Metabolic_Enzyme_4_Synonyms:
Cytosolic 5'-nucleotidase IB; cN1B; cN-IB; Autoimmune infertility-related protein

# Metabolic_Enzyme_4_Gene_Name:
NT5C1B

# Metabolic_Enzyme_4_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
BMSQTSLKQKKNEPGMRSSKESLEAEKRKESDKTGVRLSNQMRRAVNPNHSLRCCPFQGH
SSCRRCLCAAEGTALGPCHTIRIYIHMCLLWEQGQQITMMRGSQESSLRKTDSRGYLVRS
QWSRISRSPSTKAPSIDEPRSRNTSAKLPSSSTSSRTPSTSPSLHDSSPPPLSGQPSLQP
PASPQLPRSLDSRPPTPPEPDPGSRRSTKMQENPEAWAQGIVREIRQTRDSQPLEYSRTS
PTEWKSSSQRRGIYPASTQLDRNSLSEQQQQQREDEDDYEAAYWASMRSFYEKNPSCSRP
WPPKPKNAITIALSSCALFNMVDGRKIYEQEGLEKYMEYQLTNENVILTPGPAFRFVKAL
QYVNARLRDLYPDEQDLFDIVLMTNNHAQVGVRLINSVNHYGLLIDRFCLTGGKDPIGYL
KAYLTNLYIAADSEKVQEAIQEGIASATMFDGAKDMAYCDTQLRVAFDGDAVLFSDESEH
FTKEHGLDKFFQYDTLCESKPLAQGPLKGFLEDLGRLQKKFYAKNERLLCPIRTYLVTAR
SAASSGARVLKTLRRWGLEIDEALFLAGAPKSPILVKIRPHIFFDDHMFHIEGAQRLGSI
AAYGFNKKFSS

# Metabolic_Enzyme_4_Number_of_Residues:
610

# Metabolic_Enzyme_4_Molecular_Weight:
68804

# Metabolic_Enzyme_4_Theoretical_pI:
9.03

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels

# Metabolic_Enzyme_4_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_4_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
13774961

# Metabolic_Enzyme_4_SwissProt_ID:
5NT1B_HUMAN (Q96P26)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
NT5C1B

# Metabolic_Enzyme_4_Geneatlas_id:
NT5C1B

# Metabolic_Enzyme_4_hgnc_id:
HGNC:17818

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_4_Gene_Sequence:
>1699 bp
GGGCAAAAATGTGGATAACAACAAAAGAATTTCAACAGGTAAAAAAATGAGTCAAACATC
TCTCAAACAGAAAAAGAATGAGCCCGGAATGAGGTCCTCAAAAGAGAGTCTAGAAGCAGA
AAAAAGAAAGGAATCTGACAAAACAGGAGTTCGTCTGAGCAATCAGGGATCACAAGAATC
ATCACTGCGGAAGACAGACTCTCGAGGGTACCTTGTGCGCAGTCAATGGTCTAGAATATC
CCGGAGCCCATCCACCAAGGCTCCATCCATAGATGAGCCTAGAAGCAGGAACACCAGTGC
TAAGCTCCCCAGCAGCTCCACGAGCTCCCGGACTCCATCCACCTCCCCAAGCCTGCATGA
CTCCTCACCGCCGCCGCTGTCCGGGCAGCCCTCGCTCCAGCCACCCGCGTCGCCCCAGCT
GCCCCGGTCGCTGGACTCGCGGCCTCCCACGCCCCCAGAGCCCGATCCTGGCTCCCGGCG
CAGCACCAAAATGCAAGAAAATCCGGAGGCCTGGGCCCAAGGCATCGTGCGGGAAATCCG
CCAGACCCGGGACTCGCAGCCGCTGGAATATTCGCGCACGTCCCCCACCGAGTGGAAGTC
CTCCAGCCAGCGCAGGGGGATCTACCCCGCCTCCACCCAGCTGGACCGCAACTCTCTGTC
CGAGCAGCAGCAGCAGCAGCGGGAGGACGAAGACGACTACGAAGCTGCCTACTGGGCATC
CATGAAGTCGTTCTACGAAAAGAACCCGAGCTGCTGGCGCCCCTGGCCGCCCAAACCCAA
GAACGCCATCACCATTGCTCTCTCATCCTGCGCGCTCTTCAACATGGTGGACGGCAGGAA
AATCTACGAGCAAGAGGGTCTGGAAAAGTACATGGAGTATCAGCTCACCAATGAGAACGT
CATCCTGACCCCGGGCCCGGCGTTCCGTTTCGTCAAGGCACTACAGTATGTCAATGCTAG
ACTCCGTGATCTATATCCTGATGAACAGGACTTATTTGATATTGTACTGATGACTAATAA
CCATGCCCAAGTGGGAGTGCGGCTTATAAACAGCGTCAATCACTACGGCTTACTGATTGA
CCGCTTCTGTCTGACCGGGGGAAAAGACCCCATTGGCTATTTGAAGGCATATCTTACCAA
CTTGTATATTGCTGCAGATTCTGAAAAAGTGCAAGAGGCAATACAAGAAGGTATTGCCTC
TGCGACAATGTTTGATGGAGCCAAAGACATGGCTTACTGTGACACTCAGCTCCGTGTAGC
CTTTGATGGGGATGCTGTCCTCTTCTCTGATGAGTCTGAACATTTTACCAAGGAGCATGG
GCTGGACAAATTCTTCCAGTATGATACATTATGTGAAAGTAAGCCTCTTGCTCAGGGTCC
CCTAAAAGGCTTTCTGGAAGATTTAGGCAGACTGCAAAAGAAGTTCTATGCCAAAAATGA
ACGGTTACTTTGTCCTATCAGGACCTACCTGGTTACAGCTAGGAGTGCAGCCAGTTCAGG
CGCCCGTGTGCTGAAAACCTTCCGACGCTGGGGTCTAGAGATAGACGAAGCTCTTTTCCT
TGCTGGAGCCCCCAAAAGTCCCATCTTGGTGAAGATCCGGCCCCACATCTTCTTTGATGA
CCACATGTTCCACATTGAAGGGGCACAGAGGTTAGGTTCCATCGCAGCTTATGGCTTTAA
TAAAAAATTCAGTAGTTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF356185

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_4_Locus:
2p24.2

# Metabolic_Enzyme_4_SNPs:
rs3902946; rs16985301; rs16985306; rs3747660; rs2346137; rs6720633; rs7594728; rs6531109; rs6710367; rs7557821; rs4832608; rs11893074; rs16985296; rs7561652; rs2317857; rs16985292; rs16985290; rs6741218; rs11096544; rs35590292; rs10183289; rs17752103; rs11885013; rs17701334; rs16985293; rs11903725; rs7604190; rs4832609; rs7592099; rs16985311; rs16985310; rs3810839; rs17852342; rs34254789; rs7594519; rs34129467; rs7605480; rs35165251; rs7603601; rs34836771; rs34186303; rs35711606; rs35729409; rs34953851; rs11291136; rs28474708; rs3046807; rs34660980; rs35519366; rs3046840; rs35419885; rs7557722; rs4300829; rs7592233; rs13020403; rs36121694; rs34127788; rs11889898; rs13403096; rs13411442; rs1373776; rs16985281; rs16985284; rs17751951; rs2346135; rs2346136; rs34722188; rs35805648; rs3810838; rs3910894

# Metabolic_Enzyme_4_General_References:
11690631

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5229

# Metabolic_Enzyme_5_Name:
5'-nucleotidase precursor

# Metabolic_Enzyme_5_Synonyms:
Ecto-5'-nucleotidase; 5'-NT; CD73 antigen

# Metabolic_Enzyme_5_Gene_Name:
NT5E

# Metabolic_Enzyme_5_Protein_Sequence:
>5'nucleotidase precursor
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ

# Metabolic_Enzyme_5_Number_of_Residues:
574

# Metabolic_Enzyme_5_Molecular_Weight:
63368

# Metabolic_Enzyme_5_Theoretical_pI:
7.04

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  hydrolase activity, acting on ester bonds
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides

# Metabolic_Enzyme_5_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_5_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF02872:5_nucleotid_C;
PF00149:Metallophos

# Metabolic_Enzyme_5_Signals:
1-26

# Metabolic_Enzyme_5_Transmembrane_Regions:
556-573

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_5_GenBank_ID_Protein:
23897

# Metabolic_Enzyme_5_SwissProt_ID:
5NTD_HUMAN (P21589)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
NT5E

# Metabolic_Enzyme_5_Geneatlas_id:
NT5E

# Metabolic_Enzyme_5_hgnc_id:
HGNC:8021

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Metabolic_Enzyme_5_Gene_Sequence:
>1725 bp
ATGTGTCCCCGAGCCGCGCGGGCGCCCGCGACGCTACTCCTCGCCCTGGGCGCGGTGCTG
TGGCCTGCGGCTGGCGCCTGGGAGCTTACGATTTTGCACACCAACGACGTGCACAGCCGG
CTGGAGCAGACCAGCGAGGACTCCAGCAAGTGCGTCAACGCCAGCCGCTGCATGGGTGGC
GTGGCTCGGCTCTTCACCAAGGTTCAGCAGATCCGCCGCGCCGAACCCAACGTGCTGCTG
CTGGACGCCGGCGACCAGTACCAGGGCACTATCTGGTTCACCGTGTACAAGGGCGCCGAG
GTGGCGCACTTCATGAACGCCCTGCGCTACGATGCCATGGCACTGGGAAATCATGAATTT
GATAATGGTGTGGAAGGACTGATCGAGCCACTCCTCAAAGAGGCCAAATTTCCAATTCTG
AGTGCAAACATTAAAGCAAAGGGGCCACTAGCATCTCAAATATCAGGACTTTATTTGCCA
TATAAAGTTCTTCCTGTTGGTGATGAAGTTGTGGGAATCGTTGGATACACTTCCAAAGAA
ACCCCTTTTCTCTCAAATCCAGGGACAAATTTAGTGTTTGAAGATGAAATCACTGCATTA
CAACCTGAAGTAGATAAGTTAAAAACTCTAAATGTGAACAAAATTATTGCACTGGGACAT
TCGGGTTTTGAAATGGATAAACTCATCGCTCAGAAAGTGAGGGGTGTGGACGTCGTGGTG
GGAGGACACTCCAACACATTTCTTTACACAGGCAATCCACCTTCCAAAGAGGTGCCTGCT
GGGAAGTACCCATTCATAGTCACTTCTGATGATGGGCGGAAGGTTCCTGTAGTCCAGGCC
TATGCTTTTGGCAAATACCTAGGCTATCTGAAGATCGAGTTTGATGAAAGAGGAAACGTC
ATCTCTTCCCATGGAAATCCCATTCTTCTAAACAGCAGCATTCCTGAAGATCCAAGCATA
AAAGCAGACATTAACAAATGGAGGATAAAATTGGATAATTATTCTACCCAGGAATTAGGG
AAAACAATTGTCTATCTGGATGGCTCCTCTCAATCATGCCGCTTTAGAGAATGCAACATG
GGCAACCTGATTTGTGATGCAATGATTAACAACAACCTGAGACACACGGATGAAATGTTC
TGGAACCACGTATCCATGTGCATTTTAAATGGAGGTGGTATCCGGTCGCCCATTGATGAA
CGCAACAATGGCACAATTACCTGGGAGAACCTGGCTGCTGTATTGCCCTTTGGAGGCACA
TTTGACCTAGTCCAGTTAAAAGGTTCCACCCTGAAGAAGGCCTTTGAGCATAGCGTGCAC
CGCTACGGCCAGTCCACTGGAGAGTTCCTGCAGGTGGGCGGAATCCATGTGGTGTATGAT
CTTTCCCGAAAACCTGGAGACAGAGTAGTCAAATTAGATGTTCTTTGCACCAAGTGTCGA
GTGCCCAGTTATGACCCTCTCAAAATGGACGAGGTATATAAGGTGATCCTCCCAAACTTC
CTGGCCAATGGTGGAGATGGGTTCCAGATGATAAAAGATGAATTATTAAGACATGACTCT
GGTGACCAAGATATCAACGTGGTTTCTACATATATCTCCAAAATGAAAGTAATTTATCCA
GCAGTTGAAGGTCGGATCAAGTTTTCCACAGGAAGTCACTGCCATGGAAGCTTTTCTTTA
ATATTTCTTTCACTTTGGGCAGTGATCTTTGTTTTATACCAATAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X55740

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_5_Locus:
6q14-q21

# Metabolic_Enzyme_5_SNPs:
Not Available

# Metabolic_Enzyme_5_General_References:
2129526; 8566797; 2173922; 9651114

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5805

# Metabolic_Enzyme_6_Name:
Purine nucleoside phosphorylase

# Metabolic_Enzyme_6_Synonyms:
Inosine phosphorylase; PNP

# Metabolic_Enzyme_6_Gene_Name:
NP

# Metabolic_Enzyme_6_Protein_Sequence:
>Purine nucleoside phosphorylase
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS

# Metabolic_Enzyme_6_Number_of_Residues:
289

# Metabolic_Enzyme_6_Molecular_Weight:
32118

# Metabolic_Enzyme_6_Theoretical_pI:
6.95

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  purine-nucleoside phosphorylase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_6_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_6_Reaction:
purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00896:Mtap_PNP

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.4.2.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
35565

# Metabolic_Enzyme_6_SwissProt_ID:
PNPH_HUMAN (P00491)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
NP

# Metabolic_Enzyme_6_Geneatlas_id:
NP

# Metabolic_Enzyme_6_hgnc_id:
HGNC:7892

# Metabolic_Enzyme_6_PDB_ID:
1RT9

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>870 bp
ATGGAGAACGGATACACCTATGAAGATTATAAGAACACTGCAGAATGGCTTCTGTCTCAT
ACTAAGCACCGACCTCAAGTTGCAATAATCTGTGGTTCTGGATTAGGAGGTCTGACTGAT
AAATTAACTCAGGCCCAGATCTTTGACTACAGTGAAATCCCCAACTTTCCTCGAAGTACA
GTGCCAGGTCATGCTGGCCGACTGGTGTTTGGGTTCCTGAATGGCAGGGCCTGTGTGATG
ATGCAGGGCAGGTTCCACATGTATGAAGGGTACCCACTCTGGAAGGTGACATTCCCAGTG
AGGGTTTTCCACCTTCTGGGTGTGGACACCCTGGTAGTCACCAATGCAGCAGGAGGGCTG
AACCCCAAGTTTGAGGTTGGAGATATCATGCTGATCCGTGACCATATCAACCTACCTGGT
TTCAGTGGTCAGAACCCTCTCAGAGGGCCCAATGATGAAAGGTTTGGAGATCGTTTCCCT
GCCATGTCTGATGCCTACGACCGGACTATGAGGCAGAGGGCTCTCAGTACCTGGAAACAA
ATGGGGGAGCAACGTGAGCTACAGGAAGGCACCTATGTGATGGTGGCAGGCCCCAGCTTT
GAGACTGTGGCAGAATGTCGTGTGCTGCAGAAGCTGGGAGCAGACGCTGTTGGCATGAGT
ACAGTACCAGAAGTTATCGTTGCACGGCACTGTGGACTTCGAGTCTTTGGCTTCTCACTC
ATCACTAACAAGGTCATCATGGATTATGAAAGCCTGGAGAAGGCCAACCATGAAGAAGTC
TTAGCAGCTGGCAAACAAGCTGCACAGAAATTGGAACAGTTTGTCTCCATTCTTATGGCC
AGCATTCCACTCCCTGACAAAGCCAGTTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
X00737

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_6_Locus:
14q13.1

# Metabolic_Enzyme_6_SNPs:
rs1049564; rs1130650; rs1049562; rs7785; rs1617940; rs1760940; rs1713420; rs1760935; rs1713422; rs1713421; rs3790064; rs3790065; rs1713429; rs17882804; rs17880405; rs1756369; rs12147688; rs8008133; rs17881431; rs17881345; rs7154909; rs17883821; rs17885781; rs1760934; rs17879107; rs17880844; rs17879913; rs17881184; rs17885714; rs17880480; rs17883253; rs17878900; rs1713426; rs17881356; rs1713427; rs1760933; rs3790062; rs17883795; rs17112168; rs17880290; rs12147906; rs17881554; rs17881206; rs1049700; rs17882836; rs12101049; rs17884106; rs12147035; rs34480769; rs3838361; rs3842517; rs1760939; rs17885917; rs17886095; rs1760938; rs17883294; rs17883604; rs8019880; rs17881280; rs35549071; rs35139440; rs17880503; rs7151666; rs10498268; rs1079375; rs1079376; rs11846743; rs11850059; rs11850069; rs12587218; rs12886203; rs12888804; rs12891271; rs13379232; rs13379234; rs1629478; rs17112384; rs17112385; rs1713459; rs1713460; rs1713461; rs1713462; rs17242655; rs17242662; rs17242669; rs1756365; rs1760930; rs1760931; rs1760941; rs1760942; rs2077153; rs2481768; rs35175606; rs35567022; rs7156659; rs755777

# Metabolic_Enzyme_6_General_References:
6087295; 3029074; 12928150; 2104852; 1384322; 8931706

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5233

# Metabolic_Enzyme_7_Name:
Cytosolic 5'-nucleotidase 1A

# Metabolic_Enzyme_7_Synonyms:
Cytosolic 5'-nucleotidase IA; cN1A; cN-IA; cN-I

# Metabolic_Enzyme_7_Gene_Name:
NT5C1A

# Metabolic_Enzyme_7_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
AMEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSR
ALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSED
VFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKV
REAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKA
HENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSW
GLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTA
PAKQAPSAQ

# Metabolic_Enzyme_7_Number_of_Residues:
368

# Metabolic_Enzyme_7_Molecular_Weight:
41021

# Metabolic_Enzyme_7_Theoretical_pI:
6.52

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia

# Metabolic_Enzyme_7_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_7_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_7_GenBank_ID_Protein:
12659324

# Metabolic_Enzyme_7_SwissProt_ID:
5NT1A_HUMAN (Q9BXI3)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
NT5C1A

# Metabolic_Enzyme_7_Geneatlas_id:
NT5C1A

# Metabolic_Enzyme_7_hgnc_id:
HGNC:17819

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_7_Gene_Sequence:
>1107 bp
ATGGAACCTGGGCAGCCCCGGGAGCCCCAGGAGCCCCGCGAGCCCGGGCCAGGAGCGGAG
ACCGCTGCGGCCCCGGTCTGGGAGGAAGCCAAGATTTTCTACGACAACCTCGCGCCCAAG
AAGAAACCCAAATCGCCCAAGCCTCAGAATGCAGTCACCATCGCTGTGTCCTCCCGAGCC
TTGTTTCGCATGGACGAGGAGCAGCAGATCTACACGGAGCAGGGCGTGGAGGAGTACGTG
CGCTACCAGCTGGAACATGAGAACGAACCCTTCAGTCCCGGGCCAGCCTTCCCTTTTGTG
AAGGCTCTGGAGGCCGTGAACAGGCGGCTGCGGGAGCTGTACCCTGATAGTGAGGACGTC
TTCGACATCGTCCTCATGACTAACAACCATGCTCAAGTGGGTGTCCGCCTCATCAACAGT
ATCAACCACTATGACCTGTTCATCGAGAGGTTCTGCATGACAGGTGGGAACAGCCCGATC
TGCTACCTCAAGGCCTATCACACCAACCTCTACTTGTCAGCCGATGCGGAAAAAGTGCGA
GAAGCCATTGATGAGGGGATCGCAGCTGCCACCATCTTCAGCCCCAGCAGGGATGTGGTT
GTGTCCCAGAGTCAGCTGCGCGTGGCCTTCGATGGGGACGCCGTGCTCTTCTCGGACGAG
TCGGAGCGCATCGTCAAGGCCCACGGGCTGGACCGATTCTTCGAGCATGAGAAGGCCCAC
GAGAACAAGCCTCTGGCTCAGGGCCCCTTAAAGGGCTTTCTGGAGGCACTGGGTAGGTTG
CAGAAGAAGTTCTACTCCAAAGGCCTGCGGCTGGAGTGCCCAATTCGTACCTACTTGGTG
ACAGCACGCAGTGCAGCCAGTTCCGGGGCCCGGGCTCTCAAGACCCTGCGCAGCTGGGGC
CTGGAGACAGATGAAGCCTTGTTCCTTGCTGGAGCGCCCAAGGGCCCTCTCCTTGAGAAG
ATCCGCCCACACATCTTCTTTGATGACCAGATGTTCCATGTGGCTGGGGCTCAGGAGATG
GGCACTGTGGCCGCCCATGTGCCTTATGGTGTGGCACAGACACCCCGGCGGACTGCACCT
GCAAAGCAGGCCCCATCTGCACAGTAG

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AF331801

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_7_Locus:
1p34.3-p33

# Metabolic_Enzyme_7_SNPs:
rs4660340; rs784611; rs752667; rs1180272; rs1180271; rs784595; rs873917; rs1568146; rs1535031; rs3851911; rs17264901; rs784596; rs12566856; rs12406284; rs11807200; rs784597; rs784610; rs734497; rs3806428; rs784600; rs11809004; rs7553293; rs3806433; rs16826428; rs9660121; rs784599; rs3806429; rs784612; rs1533479; rs2871601; rs41264507; rs34479837; rs12035327; rs1180270; rs9439008; rs35574502; rs34779558; rs36025518; rs36123767; rs35625235; rs28507686; rs35550484; rs11206573; rs41264509; rs784598; rs34604809; rs1535030; rs5773668; rs1517187; rs12039176; rs28592113; rs784594; rs9438930; rs11306359; rs35355327; rs6684666; rs34908371; rs28667717; rs3806432; rs5773667; rs7416372; rs34045723; rs6672154; rs35002774; rs35256759; rs3806431; rs12042601; rs10465833; rs1062103; rs10839; rs10888919; rs10888929; rs11206525; rs1180275; rs1180277; rs12039225; rs12042356; rs12565281; rs13315; rs16826440; rs17501838; rs17560858; rs2281302; rs2746057; rs3207766; rs3806434; rs3916165; rs6663003; rs6703320; rs704769; rs736009; rs7419080; rs784601; rs784602; rs784613; rs784615; rs784616; rs784627; rs784629; rs784630; rs813052

# Metabolic_Enzyme_7_General_References:
11133996

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5234

# Metabolic_Enzyme_8_Name:
5'(3')-deoxyribonucleotidase, cytosolic type

# Metabolic_Enzyme_8_Synonyms:
Cytosolic 5',3'-pyrimidine nucleotidase; Deoxy-5'-nucleotidase 1; dNT-1

# Metabolic_Enzyme_8_Gene_Name:
NT5C

# Metabolic_Enzyme_8_Protein_Sequence:
>5'3'deoxyribonucleotidase, cytosolic type
MARSVRVLVDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADK
VASVYEAPGFFLDLEPIPGALDAVREMNDLPDTQVFICTSPLLKYHHCVGEKYRWVEQHL
GPQFVERIILTRDKTVVLGDLLIDDKDTVRGQEETPSWEHILFTCCHNRHLVLPPTRRRL
LSWSDNWREILDSKRGAAQRE

# Metabolic_Enzyme_8_Number_of_Residues:
201

# Metabolic_Enzyme_8_Molecular_Weight:
23383

# Metabolic_Enzyme_8_Theoretical_pI:
6.63

# Metabolic_Enzyme_8_GO_Classification:
Not Available

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP

# Metabolic_Enzyme_8_Pathway:
Not Available

# Metabolic_Enzyme_8_Reaction:
Not Available

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_8_GenBank_ID_Protein:
7524492

# Metabolic_Enzyme_8_SwissProt_ID:
NT5C_HUMAN (Q8TCD5)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
NT5C

# Metabolic_Enzyme_8_Geneatlas_id:
NT5C

# Metabolic_Enzyme_8_hgnc_id:
HGNC:17144

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_8_Gene_Sequence:
>606 bp
ATGGCGCGGAGCGTGCGCGTGCTGGTGGACATGGACGGCGTCCTGGCCGACTTCGAGGCC
GGCCTCCTGCGGGGCTTCCGCCGCCGCTTCCCTGAGGAGCCGCACGTGCCGCTGGAGCAA
CGCCGCGGCTTCCTGGCCCGCGAGCAGTACCGCGCCCTGCGGCCCGACCTGGCGGATAAA
GTGGCCAGTGTGTACGAAGCCCCGGGCTTTTTCCTGGACCTGGAGCCCATCCCGGGAGCC
TTGGACGCTGTGCGGGAGATGAACGACCTACCGGACACGCAGGTCTTCATCTGCACCAGC
CCCCTGCTGAAGTACCACCACTGTGTGGGTGAGAAGTACCGCTGGGTGGAGCAGCACCTG
GGGCCCCAGTTCGTAGAACGAATTATCCTGACAAGGGACAAGACGGTGGTCTTGGGGGAC
CTGCTCATTGATGACAAGGACACAGTTCGAGGCCAGGAGGAGACCCCAAGCTGGGAGCAC
ATCTTGTTCACCTGCTGCCACAATCGGCACCTGGTCCTGCCCCCGACAAGGAGACGGCTG
CTCTCCTGGAGTGACAACTGGAGGGAGATCTTAGATAGCAAGCGCGGAGCTGCGCAGCGG
GAATGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
AF154829

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_8_Locus:
17q25.1

# Metabolic_Enzyme_8_SNPs:
rs4788867; rs11868451; rs3736076; rs3736075; rs12453556; rs4789144; rs11652099; rs4789143; rs11541956; rs12945569; rs3188816; rs12946860; rs1048779; rs12943507; rs34746270; rs11541955; rs12945517; rs9910084; rs34454120; rs7406461; rs4788868; rs11868212; rs1551966; rs2291027; rs2291028; rs34338273; rs3752801; rs4412997; rs4789145; rs750843; rs750844; rs899316; rs899317

# Metabolic_Enzyme_8_General_References:
10681516; 12234672

# Metabolic_Enzyme_8_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7551

# Macromolecular_Interacting_Partner_1_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_1_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_1_Locus:
6p21.3

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_1_References:
10623851; 11923614; 14978744; 15979106

# Macromolecular_Interacting_Partner_2_ID:
6559

# Macromolecular_Interacting_Partner_2_Name:
Mitogen-activated protein kinase 3

# Macromolecular_Interacting_Partner_2_Synonyms:
Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAPK 1; p44-ERK1; ERT2; p44-MAPK; Microtubule- associated protein 2 kinase

# Macromolecular_Interacting_Partner_2_Gene_Name:
MAPK3

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Mitogenactivated protein kinase 3
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
379

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
43136

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.74

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00069:Pkinase

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
EC 2.7.11.24

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
31221

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
MK03_HUMAN (P27361)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
MAPK3

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
MAPK3

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:6877

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1140 bp
ATGGCGGCGGCGGCGGCTCAGGGGGGCGGGGGCGGGGAGCCCCGTAGAACCGAGGGGGTC
GGCCCGGGGGTCCCGGGGGAGGTGGAGATGGTGAAGGGGCAGCCGTTCGACGTGGGCCCG
CGCTACACGCAGTTGCAGTACATCGGCGAGGGCGCGTACGGCATGGTCAGCTCGGCCTAT
GACCACGTGCGCAAGACTCGCGTGGCCATCAAGAAGATCAGCCCCTTCGAACATCAGACC
TACTGCCAGCGCACGCTCCGGGAGATCCAGATCCTGCTGCGCTTCCGCCATGAGAATGTC
ATCGGCATCCGAGACATTCTGCGGGCGTCCACCCTGGAAGCCATGAGAGATGTCTACATT
GTGCAGGACCTGATGGAGACTGACCTGTACAAGTTGCTGAAAAGCCAGCAGCTGAGCAAT
GACCATATCTGCTACTTCCTCTACCAGATCCTGCGGGGCCTCAAGTACATCCACTCCGCC
AACGTGCTCCACCGAGATCTAAAGCCCTCCAACCTGCTCAGCAACACCACCTGCGACCTT
AAGATTTGTGATTTCGGCCTGGCCCGGATTGCCGATCCTGAGCATGACCACACCGGCTTC
CTGACGGAGTATGTGGCTACGCGCTGGTACCGGGCCCCAGAGATCATGCTGAACTCCAAG
GGCTATACCAAGTCCATCGACATCTGGTCTGTGGGCTGCATTCTGGCTGAGATGCTCTCT
AACCGGCCCATCTTCCCTGGCAAGCACTACCTGGATCAGCTCAACCACATTCTGGGCATC
CTGGGCTCCCCATCCCAGGAGGACCTGAATTGTATCATCAACATGAAGGCCCGAAACTAC
CTACAGTCTCTGCCCTCCAAGACCAAGGTGGCTTGGGCCAAGCTTTTCCCCAAGTCAGAC
TCCAAAGCCCTTGACCTGCTGGACCGGATGTTAACCTTTAACCCCAATAAACGGATCACA
GTGGAGGAAGCGCTGGCTCACCCCTACCTGGAGCAGTACTATGACCCGACGGATGAGCCA
GTGGCCGAGGAGCCCTTCACCTTCGCCATGGAGCTGGATGACCTACCTAAGGAGCGGCTG
AAGGAGCTCATCTTCCAGGAGACAGCACGCTTCCAGCCCGGAGTGCTGGAGGCCCCCTAG


# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
X60188

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_2_Locus:
16p11.2

# Macromolecular_Interacting_Partner_2_SNPs:
rs1143695; rs11865086; rs11864737; rs9921806; rs12922100; rs11863765; rs9930013; rs11546680; rs41292376; rs41291696; rs41280862; rs35691465; rs41280866; rs41280860; rs41280864; rs35666305; rs11644927; rs7199920; rs12918285; rs36084237; rs34799400; rs34564246; rs9940575; rs9940581; rs28529403; rs1042404; rs1062543; rs12924137; rs12930241; rs13569; rs1561414; rs2005219; rs3751867; rs7542; rs7698; rs8061772

# Macromolecular_Interacting_Partner_2_General_References:
7687743; 1540184; 1319925; 8794306

# Macromolecular_Interacting_Partner_2_References:
15979106

# Macromolecular_Interacting_Partner_3_ID:
6984

# Macromolecular_Interacting_Partner_3_Name:
Double-stranded RNA-specific adenosine deaminase

# Macromolecular_Interacting_Partner_3_Synonyms:
DRADA; 136 kDa double-stranded RNA-binding protein; P136; K88DSRBP; Interferon-inducible protein 4; IFI-4 protein

# Macromolecular_Interacting_Partner_3_Gene_Name:
ADAR

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Doublestranded RNAspecific adenosine deaminase
MNPRQGYSLSGYYTHPFQGYEHRQLRYQQPGPGSSPSSFLLKQIEFLKGQLPEAPVIGKQ
TPSLPPSLPGLRPRFPVLLASSTRGRQVDIRGVPRGVHLGSQGLQRGFQHPSPRGRSLPQ
RGVDCLSSHFQELSIYQDQEQRILKFLEELGEGKATTAHDLSGKLGTPKKEINRVLYSLA
KKGKLQKEAGTPPLWKIAVSTQAWNQHSGVVRPDGHSQGAPNSDPSLEPEDRNSTSVSED
LLEPFIAVSAQAWNQHSGVVRPDSHSQGSPNSDPGLEPEDSNSTSALEDPLEFLDMAEIK
EKICDYLFNVSDSSALNLAKNIGLTKARDINAVLIDMERQGDVYRQGTTPPIWHLTDKKR
ERMQIKRNTNSVPETAPAAIPETRRNAEFLTCNIPTSNASNNMVTTEKVENGQEPVIKLE
NRQEARPEPARLKPPVHYNGPSKAGYVDFENGQWATDDIPDDLNSIRAAPGEFRAIMEMP
SFYSHGLPRCSPYKKLTECQLKNPISGLLEYAQFASQTCEFNMIEQSGPPHEPRFKFQVV
INGREFPPAEAGSKKVAKQDAAMKAMTILLEEAKAKDSGKSEESSHYSTEKESEKTAESQ
TPTPSATSFFSGKSPVTTLLECMHKLGNSCEFRLLSKEGPAHEPKFQYCVAVGAQTFPSV
SAPSKKVAKQMAAEEAMKALHGEATNSMASDNQPEGMISESLDNLESMMPNKVRKIGELV
RYLNTNPVGGLLEYARSHGFAAEFKLVDQSGPPHEPKFVYQAKVGGRWFPAVCAHSKKQG
KQEAADAALRVLIGENEKAERMGFTEVTPVTGASLRRTMLLLSRSPEAQPKTLPLTGSTF
HDQIAMLSHRCFNTLTNSFQPSLLGRKILAAIIMKKDSEDMGVVVSLGTGNRCVKGDSLS
LKGETVNDCHAEIISRRGFIRFLYSELMKYNSQTAKDSIFEPAKGGEKLQIKKTVSFHLY
ISTAPCGDGALFDKSCSDRAMESTESRHYPVFENPKQGKLRTKVENGEGTIPVESSDIVP
TWDGIRLGERLRTMSCSDKILRWNVLGLQGALLTHFLQPIYLKSVTLGYLFSQGHLTRAI
CCRVTRDGSAFEDGLRHPFIVNHPKVGRVSIYDSKRQSGKTKETSVNWCLADGYDLEILD
GTRGTVDGPRNELSRVSKKNIFLLFKKLCSFRYRRDLLRLSYGEAKKAARDYETAKNYFK
KGLKDMGYGNWISKPQEEKNFYLCPV

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
1226

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
135997

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
8.81

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  RNA editase activity
Function:  double-stranded RNA adenosine deaminase activity
Function:  double-stranded RNA binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  adenosine deaminase activity
Function:  binding
Function:  nucleic acid binding
Function:  RNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  RNA processing
 ||
>>>
Component:  cell
Component:  intracellular

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site- selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF02137:A_deamin;
PF00035:dsrm;
PF02295:z-alpha

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
577170

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
DSRAD_HUMAN (P55265)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
ADAR

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
ADAR

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:225

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cytoplasm. Nucleus; nucleolus. Note=Isoform 1 is found predominantly in cytoplasm but appears to shuttle between the cytoplasm and nucleus. Isoform 5 is found exclusively in the nucleolus

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>3681 bp
ATGAATCCGCGGCAGGGGTATTCCCTCAGCGGATACTACACCCATCCATTTCAAGGCTAT
GAGCACAGACAGCTCAGATACCAGCAGCCTGGGCCAGGATCTTCCCCCAGTAGTTTCCTG
CTTAAGCAAATAGAATTTCTCAAGGGGCAGCTCCCAGAAGCACCGGTGATTGGAAAGCAG
ACACCGTCACTGCCACCTTCCCTCCCAGGACTCCGGCCAAGGTTTCCAGTACTACTTGCC
TCCAGTACCAGAGGCAGGCAAGTGGACATCAGGGGTGTCCCCAGGGGCGTGCATCTCGGA
AGTCAGGGGCTCCAGAGAGGGTTCCAGCATCCTTCACCACGTGGCAGGAGTCTGCCACAG
AGAGGTGTTGATTGCCTTTCCTCACATTTCCAGGAACTGAGTATCTACCAAGATCAGGAA
CAAAGGATCTTAAAGTTCCTGGAAGAGCTTGGGGAAGGGAAGGCCACCACAGCACATGAT
CTGTCTGGGAAACTTGGGACTCCGAAGAAAGAAATCAATCGAGTTTTATACTCCCTGGCA
AAGAAGGGCAAGCTACAGAAAGAGGCAGGAACACCCCCTTTGTGGAAAATCGCGGTCTCC
ACTCAGGCTTGGAACCAGCACAGCGGAGTGGTAAGACCAGACGGTCATAGCCAAGGAGCC
CCAAACTCAGACCCGAGTTTGGAACCGGAAGACAGAAACTCCACATCTGTCTCAGAAGAT
CTTCTTGAGCCTTTTATTGCAGTCTCAGCTCAGGCTTGGAACCAGCACAGCGGAGTGGTA
AGACCAGACAGTCATAGCCAAGGATCCCCAAACTCAGACCCAGGTTTGGAACCTGAAGAC
AGCAACTCCACATCTGCCTTGGAAGATCCTCTTGAGTTTTTAGACATGGCCGAGATCAAG
GAGAAAATCTGCGACTATCTCTTCAATGTGTCTGACTCCTCTGCCCTGAATTTGGCTAAA
AATATTGGCCTTACCAAGGCCCGAGATATAAATGCTGTGCTAATTGACATGGAAAGGCAG
GGGGATGTCTATAGACAAGGGACAACCCCTCCCATATGGCATTTGACAGACAAGAAGCGA
GAGAGGATGCAAATCAAGAGAAATACGAACAGTGTTCCTGAAACCGCTCCAGCTGCAATC
CCTGAGACCAAAAGAAACGCAGAGTTCCTCACCTGTAATATACCCACATCAAATGCCTCA
AATAACATGGTAACCACAGAAAAAGTGGAGAATGGGCAGGAACCTGTCATAAAGTTAGAA
AACAGGCAAGAGGCCAGACCAGAACCAGCAAGACTGAAACCACCTGTTCATTACAATGGC
CCCTCAAAAGCAGGGTATGTTGACTTTGAAAATGGCCAGTGGGCCACAGATGACATCCCA
GATGACTTGAATAGTATCCGCGCAGCACCAGGTGAGTTTCGAGCCATCATGGAGATGCCC
TCCTTCTACAGTCATGGCTTGCCACGGTGTTCACCCTACAAGAAACTGACAGAGTGCCAG
CTGAAGAACCCCATCAGCGGGCTGTTAGAATATGCCCAGTTCGCTAGTCAAACCTGTGAG
TTCAACATGATAGAGCAGAGTGGACCACCCCATGAACCTCGATTTAAATTCCAGGTTGTC
ATCAATGGCCGAGAGTTTCCCCCAGCTGAAGCTGGAAGCAAGAAAGTGGCCAAGCAGGAT
GCAGCTATGAAAGCCATGACAATTCTGCTAGAGGAAGCCAAAGCCAAGGACAGTGGAAAA
TCAGAAGAATCATCCCACTATTCCACAGAGAAAGAATCAGAGAAGACTGCAGAGTCCCAG
ACCCCCACCCCTTCAGCCACATCCTTCTTTTCTGGGAAGAGCCCCGTCACCACACTGCTT
GAGTGTATGCACAAATTGGGGAACTCCTGCGAATTCCGTCTCCTGTCCAAAGAAGGCCCT
GCCCATGAACCCAAGTTCCAATACTGTGTTGCAGTGGGAGCCCAAACTTTCCCCAGTGTG
AGTGCTCCCAGCAAGAAAGTGGCAAAGCAGATGGCCGCAGAGGAAGCCATGAAGGCCCTG
CATGGGGAGGCGACCAACTCCATGGCTTCTGATAACCAGCCTGAAGGTATGATCTCAGAG
TCACTTGATAACTTGGAATCCATGATGCCCAACAAGGTCAGGAAGATTGGCGAGCTCGTG
AGATACCTGAACACCAACCCTGTGGGTGGCCTTTTGGAGTACGCCCGCTCCCATGGCTTT
GCTGCTGAATTCAAGTTGGTCGACCAGTCCGGACCTCCTCACGAGCCCAAGTTCGTTTAC
CAAGCAAAAGTTGGGGGTCGCTGGTTCCCAGCCGTCTGCGCACACAGCAAGAAGCAAGGC
AAGCAGGAAGCAGCAGATGCGGCTCTCCGTGTCTTGATTGGGGAGAACGAGAAGGCAGAA
CGCATGGGTTTCACAGAGGTAACCCCAGTGACAGGGGCCAGTCTCAGAAGAACTATGCTC
CTCCTCTCAAGGTCCCCAGAAGCACAGCCAAAGACACTCCCTCTCACTGGCAGCACCTTC
CATGACCAGATAGCCATGCTGAGCCACCGGTGCTTCAACACTCTGACTAACAGCTTCCAG
CCCTCCTTGCTCGGCCGCAAGATTCTGGCCGCCATCATTATGAAAAAAGACTCTGAGGAC
ATGGGTGTCGTCGTCAGCTTGGGAACAGGGAATCGCTGTGTGAAAGGAGATTCTCTCAGC
CTAAAAGGAGAAACTGTCAATGACTGCCATGCAGAAATAATCTCCCGGAGAGGCTTCATC
AGGTTTCTCTACAGTGAGTTAATGAAATACAACTCCCAGACTGCGAAGGATAGTATATTT
GAACCTGCTAAGGGAGGAGAAAAGCTCCAAATAAAAAAGACTGTGTCATTCCATCTGTAT
ATCAGCACTGCTCCGTGTGGAGATGGCGCCCTCTTTGACAAGTCCTGCAGCGACCGTGCT
ATGGAAAGCACAGAATCCCGCCACTACCCTGTCTTCGAGAATCCCAAACAAGGAAAGCTC
CGCACCAAGGTGGAGAACGGAGAAGGCACAATCCCTGTGGAATCCAGTGACATTGTGCCT
ACGTGGGATGGCATTCGGCTCGGGGAGAGACTCCGTACCATGTCCTGTAGTGACAAAATC
CTACGCTGGAACGTGCTGGGCCTGCAAGGGGCACTGTTGACCCACTTCCTGCAGCCCATT
TATCTCAAATCTGTCACATTGGGTTACCTTTTCAGCCAAGGGCATCTGACCCGTGCTATT
TGCTGTCGTGTGACAAGAGATGGGAGTGCATTTGAGGATGGACTACGACATCCCTTTATT
GTCAACCACCCCAAGGTTGGCAGAGTCAGCATATATGATTCCAAAAGGCAATCCGGGAAG
ACTAAGGAGACAAGCGTCAACTGGTGTCTGGCTGATGGCTATGACCTGGAGATCCTGGAC
GGTACCAGAGGCACTGTGGATGGGCCACGGAATGAATTGTCCCGGGTCTCCAAAAAGAAC
ATTTTTCTTCTATTTAAGAAGCTCTGCTCCTTCCGTTACCGCAGGGATCTACTGAGACTC
TCCTATGGTGAGGCCAAGAAAGCTGCCCGTGACTACGAGACGGCCAAGAACTACTTCAAA
AAAGGCCTGAAGGATATGGGCTATGGGAACTGGATTAGCAAACCCCAGGAGGAAAAGAAC
TTTTATCTCTGCCCAGTATAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
U10439

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_3_Locus:
1q21.1-q21.2

# Macromolecular_Interacting_Partner_3_SNPs:
rs2229857; rs17843865; rs1466731; rs1127309; rs1802645; rs17843864; rs3766922; rs1127314; rs7531982; rs1127326; rs9616; rs1127317; rs3766923; rs962242; rs7548889; rs2335229; rs3738029; rs1994922; rs4845384; rs9426830; rs4636449; rs4486443; rs11264228; rs1127313; rs2335230; rs1127311; rs9427104; rs9426827; rs12125166; rs6699825; rs9427100; rs6699729; rs9426828; rs6426859; rs9426826; rs9427103; rs6694084; rs11802588; rs3738031; rs16361; rs12737599; rs9426829; rs9427102; rs12758627; rs11579998; rs7537208; rs34167604; rs6702549; rs4845381; rs3738030; rs6702449; rs34010281; rs903323; rs1542796; rs3766927; rs9427095; rs9426823; rs3738032; rs10908419; rs1389759; rs3766924; rs3766925; rs2131902; rs2172708; rs9427097; rs3766926; rs6677920; rs903324; rs6683149; rs903321; rs17843867; rs17655362; rs12141385; rs12568696; rs11264224; rs11578437; rs17843869; rs9427094; rs16836107; rs1552901; rs12410752; rs17843866; rs35597061; rs11264223; rs903322; rs16836117; rs12086987; rs11264222; rs884618; rs6656743; rs7533471; rs884617; rs11806816; rs4845656; rs6690277; rs28411375; rs7546383; rs1494396; rs4845655; rs9427092; rs7544062; rs7515339; rs28936681; rs34154757; rs28936680; rs2131901; rs11545928; rs1127310; rs35801582; rs34402967; rs12128435; rs11374337; rs35572253; rs28483836; rs1139666; rs36008606; rs35340607; rs10565297; rs10712198; rs11264227; rs34273814; rs34298833; rs11264226; rs34888919; rs35504625; rs34198042; rs28655693; rs34323454; rs9427105; rs4845382; rs962243; rs3183534; rs34484012; rs35587075; rs2070049; rs12117101; rs11282592; rs34442119; rs14002; rs34574258; rs34126801; rs1389758; rs6669764; rs11545929; rs34950403; rs10698443; rs34840081; rs34718440; rs1802644; rs4845383; rs35549045; rs34782235; rs5777919; rs1802729; rs35581448; rs35943124; rs35444697; rs11280324; rs34943894; rs35567720; rs1007839; rs34148770; rs35983933; rs4845654; rs12024727; rs9427101; rs2055118; rs36121466; rs11545926; rs35160350; rs1139667; rs12059682; rs12094866; rs12748485; rs34651139; rs2172707; rs34008074; rs12045145; rs12045204; rs4045821; rs33946420; rs7532276; rs12139887; rs11335288; rs5777920; rs4845380; rs2088051; rs35232225; rs3215061; rs35428129; rs35732986; rs11324601; rs9427096; rs12023324; rs9427098; rs5777921; rs34909675; rs28411376; rs34464828; rs6682854; rs11264221; rs11264229; rs11264231; rs11264232; rs1126885; rs11803785; rs12079381; rs12092890; rs1552902; rs2072659; rs2072660; rs2072661; rs2975130; rs2975132; rs2975133; rs3008433; rs3811450; rs4292956; rs4845378; rs4845653; rs6426862; rs6700656; rs7553021; rs9426831; rs9427108; rs955739

# Macromolecular_Interacting_Partner_3_General_References:
7972084; 7565688; 9020165; 12618436; 10364558; 10535945

# Macromolecular_Interacting_Partner_3_References:
10629039; 12709013; 15355102; 16956888

# Macromolecular_Interacting_Partner_4_ID:
7754

# Macromolecular_Interacting_Partner_4_Name:
RNA editing deaminase 1

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
hRED1

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>RNA editing deaminase 1
MDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSN
GHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVF
EGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGF
ETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLAQPPLPVLPPFPPPSGKNPVMIL
NELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALAAIFNLH
LDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTG
TDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDD
QKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEGSRSYTQAGVQWCNH
GSLQPRPPGLLSDPSTSTFQGAGTTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQ
TWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAM
YQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATTGKDE
LGRASRLCKHALYCRWXACARQGSLPLTTLQDYQAQRVP

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
699

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
75916

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.81

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  double-stranded RNA binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  adenosine deaminase activity
Function:  binding
Function:  nucleic acid binding
Function:  RNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  RNA processing
 ||
>>>
Component:  cell
Component:  intracellular

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF02137:A_deamin;
PF00035:dsrm

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
4379098

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
O43263_HUMAN (O43263)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
hRED1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
hRED1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:226

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>28 bp
ATGGATATAGAAGATGAAGAAAACATGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
Z95976

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_4_Locus:
Not Available

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
Not Available

# Macromolecular_Interacting_Partner_4_References:
10629039; 16956888

# Macromolecular_Interacting_Partner_5_ID:
7968

# Macromolecular_Interacting_Partner_5_Name:
TATA-box-binding protein

# Macromolecular_Interacting_Partner_5_Synonyms:
TATA-box factor; TATA-binding factor; TATA sequence-binding protein; Transcription initiation factor TFIID TBP subunit

# Macromolecular_Interacting_Partner_5_Gene_Name:
TBP

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>TATAboxbinding protein
MDQNNSLPPYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPIQNTNSLSILEEQQRQQQ
QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAVAAAAVQQSTSQQATQGTSGQAPQ
LFHSQTLTTAPLPGTTPLYPSPMTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDL
KTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARV
VQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRI
VLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
339

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
37699

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
10.29

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  transcription regulator activity
Function:  RNA polymerase II transcription factor activity
Function:  nucleic acid binding
Function:  DNA binding
Function:  binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  transcription
Process:  transcription, DNA-dependent
Process:  transcription initiation
Process:  transcription initiation from RNA polymerase II promoter
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  protein complex
Component:  transcription factor complex
Component:  transcription factor TFIID complex
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_5_General_Function:
Transcription 

# Macromolecular_Interacting_Partner_5_Specific_Function:
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00352:TBP

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
339492

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
TBP_HUMAN (P20226)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
TBP

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
TBP

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:11588

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1020 bp
ATGGATCAGAACAACAGCCTGCCACCTTACGCTCAGGGCTTGGCCTCCCCTCAGGGTGCC
ATGACTCCCGGAATCCCTATCTTTAGTCCAATGATGCCTTATGGCACTGGACTGACCCCA
CAGCCTATTCAGAACACCAATAGTCTGTCTATTTTGGAAGAGCAACAAAGGCAGCAGCAG
CAACAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAACAGCAGCAGCAGCAG
CAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGGCAGTGGCAGCTGCA
GCCGTTCAGCAGTCAACGTCCCAGCAGGCAACACAGGGAACCTCAGGCCAGGCACCACAG
CTCTTCCACTCACAGACTCTCACAACTGCACCCTTGCCGGGCACCACTCCACTGTATCCC
TCCCCCATGACTCCCATGACCCCCATCACTCCTGCCACGCCAGCTTCGGAGAGTTCTGGG
ATTGTACCGCAGCTGCAAAATATTGTATCCACAGTGAATCTTGGTTGTAAACTTGACCTA
AAGACCATTGCACTTCGTGCCCGAAACGCCGAATATAATCCCAAGCGGTTTGCTGCGGTA
ATCATGAGGATAAGAGAGCCACGAACCACGGCACTGATTTTCAGTTCTGGGAAAATGGTG
TGCACAGGAGCCAAGAGTGAAGAACAGTCCAGACTGGCAGCAAGAAAATATGCTAGAGTT
GTACAGAAGTTGGGTTTTCCAGCTAAGTTCTTGGACTTCAAGATTCAGAACATGGTGGGG
AGCTGTGATGTGAAGTTTCCTATAAGGTTAGAAGGCCTTGTGCTCACCCACCAACAATTT
AGTAGTTATGAGCCAGAGTTATTTCCTGGTTTAATCTACAGAATGATCAAACCCAGAATT
GTTCTCCTTATTTTTGTTTCTGGAAAAGTTGTATTAACAGGTGCTAAAGTCAGAGCAGAA
ATTTATGAAGCATTTGAAAACATCTACCCTATTCTAAAGGGATTCAGGAAGACGACGTAA


# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
M55654

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_5_Locus:
6q27

# Macromolecular_Interacting_Partner_5_SNPs:
Not Available

# Macromolecular_Interacting_Partner_5_General_References:
2363050; 2194289; 2374612; 14574404; 7801123; 9748258; 10196196; 10567404; 10391676; 11438666; 12217962; 8643494; 8757291; 10619841; 11461703; 10484774; 11313753; 11448935; 11939898

# Macromolecular_Interacting_Partner_5_References:
10217450; 11891629; 14695279

# Macromolecular_Interacting_Partner_6_ID:
8452

# Macromolecular_Interacting_Partner_6_Name:
Lymphotoxin-beta

# Macromolecular_Interacting_Partner_6_Synonyms:
LT-beta; Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3

# Macromolecular_Interacting_Partner_6_Gene_Name:
LTB

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Lymphotoxinbeta
MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD
PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS
DAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLE
GAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGA
VMVG

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
244

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
25390

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
5.02

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_6_Signals:
1-35

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
292279

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
TNFC_HUMAN (Q06643)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
LTB

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
LTB

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:6711

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>735 bp
ATGGGGGCACTGGGGCTGGAGGGCAGGGGTGGGAGGCTCCAGGGGAGGGGTTCCCTCCTG
CTAGCTGTGGCAGGAGCCACTTCTCTGGTGACCTTGTTGCTGGCGGTGCCTATCACTGTC
CTGGCTGTGCTGGCCTTAGTGCCCCAGGATCAGGGAGGACTGGTAACGGAGACGGCCGAC
CCCGGGGCACAGGCCCAGCAAGGACTGGGGTTTCAGAAGCTGCCAGAGGAGGAGCCAGAA
ACAGATCTCAGCCCCGGGCTCCCAGCTGCCCACCTCATAGGCGCTCCGCTGAAGGGGCAG
GGGCTAGGCTGGGAGACGACGAAGGAACAGGCGTTTCTGACGAGCGGGACGCAGTTCTCG
GACGCCGAGGGGCTGGCGCTCCCGCAGGACGGCCTCTATTACCTCTACTGTCTCGTCGGC
TACCGGGGCCGGGCGCCCCCTGGCGGCGGGGACCCCCAGGGCCGCTCGGTCACGCTGCGC
AGCTCTCTGTACCGGGCGGGGGGCGCCTACGGGCCGGGCACTCCCGAGCTGCTGCTCGAG
GGCGCCGAGACGGTGACTCCAGTGCTGGACCCGGCCAGGAGACAAGGGTACGGGCCTCTC
TGGTACACGAGCGTGGGGTTCGGCGGCCTGGTGCAGCTCCGGAGGGGCGAGAGGGTGTAC
GTCAACATCAGTCACCCCGATATGGTGGACTTCGCGAGAGGGAAGACCTTCTTTGGGGCC
GTGATGGTGGGGTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
L11016

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_6_Locus:
6p21.3

# Macromolecular_Interacting_Partner_6_SNPs:
Not Available

# Macromolecular_Interacting_Partner_6_General_References:
7916655; 9299492; 10202016

# Macromolecular_Interacting_Partner_6_References:
10623851

# Macromolecular_Interacting_Partner_7_ID:
8758

# Macromolecular_Interacting_Partner_7_Name:
Equilibrative nucleoside transporter 2

# Macromolecular_Interacting_Partner_7_Synonyms:
Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter; Equilibrative NBMPR-insensitive nucleoside transporter; Nucleoside transporter, ei-type; Solute carrier family 29 member 2; 36 kDa nucleolar protein HNP36; Hydrophobic nucleolar protein, 36 kDa; Delayed-early response protein 12

# Macromolecular_Interacting_Partner_7_Gene_Name:
SLC29A2

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Equilibrative nucleoside transporter 2
MARGDAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGNSTARILSTNHTG
PEDAFNFNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGSLLAILLLFALTAALVKVD
MSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLL
SMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQELETKAE
LLQSDENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLV
FTVTLSVFPAITAMVTSSTSPGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRL
LPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPR
QVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
456

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
50114

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.02

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
 Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_7_Signals:
1-24

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
13-33
70-90
99-119
124-144
162-182
193-213
291-311
324-344
360-380
386-406
432-452

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
2811137

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
S29A2_HUMAN (Q14542)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
SLC29A2

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
SLC29A2

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:11004

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Isoform 1:Cell membrane; multi-pass membrane protein. Isoform 2:Nucleus; nuclear membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1371 bp
ATGGCGCGAGGAGACGCCCCGCGGGACAGCTACCACCTGGTCGGGATCAGCTTCTTCATC
CTGGGGCTGGGCACCCTCCTTCCCTGGAACTTCTTCATCACCGCCATCCCGTACTTCCAG
GCGCGACTGGCCGGGGCCGGCAACAGCACAGCCAGGATCCTGAGCACCAACCACACGGGT
CCCGAGGATGCCTTCAACTTCAACAATTGGGTGACGCTGCTGTCCCAGCTGCCCCTGCTG
CTCTTCACCCTCCTCAACTCCTTCCTGTACCAGTGCGTCCCGGAGACGGTGCGCATTCTG
GGCAGCCTGCTGGCCATACTGCTGCTCTTTGCCCTGACAGCAGCGCTGGTCAAGGTGGAC
ATGAGCCCCGGACCCTTCTTCTCCATCACCATGGCCTCCGTCTGCTTCATCAACTCCTTC
AGTGCAGTCCTACAGGGCAGCCTCTTCGGGCAGCTGGGCACCATGCCCTCCACCTACAGC
ACCCTCTTCCTCAGCGGCCAGGGCCTGGCTGGGATCTTTGCTGCCCTTGCCATGCTCCTG
TCCATGGCCAGTGGCGTGGACGCCGAGACCTCTGCCCTGGGGTACTTTATCACGCCCTGT
GTGGGCATCCTCATGTCCATCGTGTGTTACCTGAGCCTGCCTCACCTGAAGTTTGCCCGC
TACTACCTGGCCAATAAATCATCCCAGGCCCAAGCTCAGGAGCTGGAGACCAAAGCTGAG
CTCCTCCAGTCTGATGAGAACGGGATTCCCAGTAGTCCCCAGAAAGTAGCTCTGACCCTG
GATCTTGACCTGGAGAAGGAGCCGGAATCAGAGCCAGATGAGCCCCAGAAGCCAGGAAAA
CCTTCAGTCTTCACTGTCTTCCAGAAGATCTGGCTGACAGCGCTGTGCCTTGTGTTGGTC
TTCACAGTCACCCTGTCCGTCTTCCCCGCCATCACAGCCATGGTGACCAGCTCCACCAGT
CCTGGGAAGTGGAGTCAGTTCTTCAACCCCATCTGCTGCTTCCTCCTCTTCAACATCATG
GACTGGCTGGGACGGAGCCTGACCTCTTACTTCCTGTGGCCAGACGAGGACAGCCGGCTG
CTGCCCCTGCTGGTCTGCCTGCGGTTCCTGTTCGTGCCCCTCTTCATGCTGTGCCACGTG
CCCCAGAGGTCCCGGCTGCCCATCCTCTTCCCACAGGATGCCTACTTCATCACCTTCATG
CTGCTCTTTGCCGTTTCTAATGGCTACCTGGTGTCCCTCACCATGTGCCTGGCGCCCAGG
CAGGTGCTGCCACACGAGAGGGAGGTGGCCGGCGCCCTCATGACCTTCTTCCTGGCCCTG
GGACTTTCCTGTGGAGCCTCCCTCTCCTTCCTCTTCAAGGCGCTGCTCTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
AF034102

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_7_Locus:
11q13

# Macromolecular_Interacting_Partner_7_SNPs:
rs8187661; rs1039593; rs3177514; rs4930358; rs7126064; rs2292123; rs2279861; rs2279862; rs7125100; rs7126018; rs12416747; rs1039594; rs10791872; rs8187658; rs3867130; rs12576299; rs1344410; rs12576293; rs12577196; rs4930178; rs4930359; rs12281049; rs4244813; rs7107191; rs7104297; rs17850744; rs17855425; rs12801227; rs34186490; rs34124904; rs11227466; rs4554890; rs3741366; rs10605893; rs11403442; rs7111197; rs10632640; rs35639157; rs35962792; rs7946434; rs33943132; rs34029417; rs1815807; rs35659701; rs7103571; rs35791794; rs10648232; rs11423263; rs34482391; rs1566871; rs11298226; rs12800796; rs35509820; rs11461356; rs35457397; rs1201452; rs1210071; rs34585457; rs12360603; rs1047029; rs10791871; rs12794121; rs34272485; rs7130857; rs8187644; rs8187646; rs8187647; rs8187657; rs8187659; rs8187660

# Macromolecular_Interacting_Partner_7_General_References:
9478986; 9396714; 7639753

# Macromolecular_Interacting_Partner_7_References:
Not Available

# Macromolecular_Interacting_Partner_8_ID:
8857

# Macromolecular_Interacting_Partner_8_Name:
Equilibrative nucleoside transporter 3

# Macromolecular_Interacting_Partner_8_Synonyms:
Solute carrier family 29 member 3

# Macromolecular_Interacting_Partner_8_Gene_Name:
SLC29A3

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Equilibrative nucleoside transporter 3
MAVVSEDDFQHSSNSTYRTTSSSLRADQEALLEKLLDRPPPGLQRPEDRFCGTYIIFFSL
GIGSLLPWNFFITAKEYWMFKLRNSSSPATGEDPEGSDILNYFESYLAVASTVPSMLCLV
ANFLLVNRVAVHIRVLASLTVILAIFMVITALVKVDTFSWTRGFFAVTIVCMVILSGAST
VFSSSIYGMTGSFPMRNSQALISGGAMGGTVSAVASLVDLAASSDVRNSALAFFLTATIF
LVLCMGLYLLLSRLEYARYYMRPVLAAHVFSGEEELPQDSLSAPSVASRFIDSHTPPLRP
ILKKTASLGFCVTYVFFITSLIYPAVCTNIESLNKGSGSLWTTKFFIPLTTFLLYNFADL
CGRQLTAWIQVPGPNSKALPGFVLLRTCLIPLFVLCNYQPRVHLKTVVFQSDVYPALLSS
LLGLSNGYLSTLALLYGPKIVPRELAEATGVVMSFYVCLGLTLGSACSTLLVHLI

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
475

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
51875

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
7.85

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
 Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter)

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_8_Signals:
Not Available

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
50-72
107-126
131-153
163-185
198-220
230-252
308-330
340-357
378-395
415-437
450-472

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
12656639

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
S29A3_HUMAN (Q9BZD2)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
SLC29A3

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
SLC29A3

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:23096

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1428 bp
ATGGCCGTTGTCTCAGAGGACGACTTTCAGCACAGTTCAAACTCCACCTACAGAACCACA
AGCAGCAGTCTCCGAGCTGACCAGGAGGCACTGCTTGAGAAGCTGCTGGACCGCCCGCCC
CCTGGCCTGCAGAGGCCCGAGGACCGCTTCTGTGGCACATACATCATCTTCTTCAGCCTG
GGCATTGGCAGTCTACTGCCATGGAACTTCTTTATCACTGCCAAGGAGTACTGGATGTTC
AAACTCCGCAACTCCTCCAGCCCAGCCACCGGGGAGGACCCTGAGGGCTCAGACATCCTG
AACTACTTTGAGAGCTACCTTGCCGTTGCCTCCACCGTGCCCTCCATGCTGTGCCTGGTG
GCCAACTTCCTGCTTGTCAACAGGGTTGCAGTCCACATCCGTGTCCTGGCCTCACTGACG
GTCATCCTGGCCATCTTCATGGTGATAACTGCACTGGTGAAGGTGGACACTTTCTCCTGG
ACCCGTGGCTTTTTTGCGGTCACCATTGTCTGCATGGTGATCCTCAGCGGTGCCTCCACT
GTCTTCAGCAGCAGCATCTACGGCATGACCGGCTCCTTTCCTATGAGGAACTCCCAGGCA
CTGATATCAGGAGGAGCCATGGGCGGGACGGTCAGCGCCGTGGCCTCATTGGTGGACTTG
GCTGCATCCAGTGATGTGAGGAACAGCGCCCTGGCCTTCTTCCTGACGGCCACCATCTTC
CTCGTGCTCTGCATGGGACTCTACCTGCTGCTGTCCAGGCTGGAGTATGCCAGGTACTAC
ATGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGAAGAGGAGCTTCCCCAGGACTCC
CTCAGTGCCCCTTCGGTGGCCTCCAGATTCATTGATTCCCACACACCCCCTCTCCGCCCC
ATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGTCTTCTTCATCACCAGC
CTCATCTACCCCGCCGTCTGCACCAACATCGAGTCCCTCAACAAGGGCTCGGGCTCACTG
TGGACCACCAAGTTTTTCATCCCCCTCACTACCTTCCTCCTGTACAACTTTGCTGACCTA
TGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAATAGCAAGGCGCTCCCA
GGGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTTCGTGCTCTGTAACTACCAGCCC
CGCGTCCACCTGAAGACTGTGGTCTTCCAGTCCGATGTGTACCCCGCACTCCTCAGCTCC
CTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCTCTACGGGCCTAAGATT
GTGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGATGTCCTTTTATGTGTGCTTGGGC
TTAACACTGGGCTCAGCCTGCTCTACCCTCCTGGTGCACCTCATCTAG

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
AF326987

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_8_Locus:
10q22.1

# Macromolecular_Interacting_Partner_8_SNPs:
rs2487068; rs2252996; rs780668; rs2277257; rs999940; rs16928737; rs2252997; rs1084004; rs2275579; rs780680; rs780664; rs1538899; rs780660; rs780659; rs780666; rs703257; rs780654; rs946875; rs703256; rs2394793; rs7069807; rs1110399; rs780677; rs4600131; rs780675; rs2243460; rs780670; rs780676; rs6480510; rs2487067; rs6480511; rs809691; rs883764; rs7086724; rs12256138; rs2012500; rs780662; rs4494244; rs780672; rs780653; rs3781314; rs2249987; rs1538895; rs2066211; rs780655; rs10823723; rs1316421; rs11815656; rs3824770; rs7100381; rs2250002; rs6480513; rs12251921; rs12767108; rs16928705; rs10999773; rs10999778; rs1572810; rs7076329; rs6480514; rs780667; rs7090745; rs2249882; rs883763; rs780679; rs780674; rs7080325; rs3781316; rs2249989; rs780678; rs11812689; rs780669; rs2487066; rs2243496; rs7067629; rs10999776; rs7095417; rs11594628; rs780665; rs4430425; rs4348816; rs780661; rs3781311; rs3781313; rs2249753; rs10999770; rs7091983; rs884031; rs3781324; rs780658; rs10999775; rs7072838; rs780671; rs946973; rs10740374; rs12252326; rs3781310; rs10999771; rs3781309; rs3781312; rs1890885; rs2243540; rs3758570; rs3781317; rs2066209; rs780656; rs7900534; rs7083031; rs2066210; rs6480512; rs12220541; rs884681; rs3781327; rs16928722; rs7068179; rs7090777; rs12249513; rs10740375; rs7913673; rs780673; rs10999777; rs10999781; rs780657; rs7090611; rs884680; rs3781326; rs7086520; rs7071162; rs7071738; rs2249752; rs12252139; rs17525188; rs12252279; rs2243485; rs7071979; rs10999772; rs3781325; rs7087714; rs7084342; rs4747148; rs7924115; rs946979; rs780681; rs1572812; rs35065420; rs6650127; rs34069552; rs10716665; rs35206666; rs12263170; rs10625840; rs34905233; rs11376986; rs35919163; rs5786035; rs34110374; rs12356731; rs35335105; rs12269478; rs12243734; rs34152212; rs7913062; rs3059614; rs12762394; rs7911708; rs7914132; rs4746081; rs7094989; rs35701283; rs12267767; rs12220170; rs7068296; rs34294547; rs35368644; rs41281300; rs3781318; rs4641383; rs7916422; rs34315182; rs10999774; rs35720104; rs10999769; rs35239123; rs7077024; rs3837344; rs7913610; rs10552605; rs10999779; rs780663; rs35509882; rs3893272; rs3059612; rs35156362; rs1609652; rs35485497; rs34058912; rs12243650; rs4147262; rs7903407; rs35942216; rs12763826; rs3837345; rs34297699; rs34965758; rs3824768; rs34491538; rs41300554; rs36074226; rs7095479; rs7067937; rs11296364; rs35855172; rs7897272; rs34640546; rs3781315; rs34395748; rs12355187; rs12261581; rs10686987; rs12779065; rs10999783; rs36087675; rs12762772; rs5786034; rs10999782; rs34650529; rs34632350; rs10553895; rs34721394; rs12249991; rs11593088; rs3059610; rs28708771; rs35956296; rs10999768; rs28688626; rs35685893; rs10823722; rs10999766; rs10999784; rs10999785; rs10999786; rs10999788; rs11595617; rs11816935; rs12098507; rs12254223; rs12412201; rs12414898; rs1538898; rs1609651; rs17546494; rs2185416; rs2248674; rs34217506; rs35016944; rs35685474; rs7079524; rs780682; rs780683; rs780687; rs780688; rs780689; rs780690; rs780692; rs780693; rs780694; rs780695; rs780697; rs780698; rs7895122; rs7899555; rs869545; rs946879

# Macromolecular_Interacting_Partner_8_General_References:
11396612; 12384580; 12975309

# Macromolecular_Interacting_Partner_8_References:
Not Available

End of HMDB00195

Beginning of HMDB00197
# Accession_No:
HMDB00197

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-13 11:34:58

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Indoleacetic acid

# Description:
Indoleacetic acid (IAA) is a member of the group of phytohormones called auxins. IAA is generally considered to be the most important native auxin. Plant cells synthesize IAA from tryptophan. (wikipedia)
IAA and some derivatives can be oxidised by horseradish peroxidase (HRP) to cytotoxic species. IAA is only toxic after oxidative decarboxylation; the effect of IAA/HRP is thought to be due in part to the formation of methylene-oxindole, which may conjugate with DNA bases and protein thiols. IAA/HRP could be used as the basis for targeted cancer, a potential new role for plant auxins in cancer therapy. (PMID: 11163327)

# Synonyms:
(1H-Indol-3-yl)-acetate; (1H-Indol-3-yl)-acetic acid; 1H-Indole-3-acetate; 1H-Indole-3-acetic acid; 1H-indol-3-ylacetate; 1H-indol-3-ylacetic acid; 2-(1H-indol-3-yl)acetate; 2-(1H-indol-3-yl)acetic acid; 2-(3-Indolyl)acetate; 2-(3-Indolyl)acetic acid; 3-(Carboxymethyl)indole; 3-IAA; 3-Indole-Acetic acid; 3-Indoleacetate; 3-Indoleacetic acid; 3-Indolylacetate; 3-Indolylacetic acid; Heteroauxin; Indol-3-ylacetate; Indol-3-ylacetic acid; Indole-3-acetate; Indole-3-acetic acid; Indoleacetate; Indoleacetic acid; Indolyl-3-acetate; Indolyl-3-acetic acid; Indolylacetate; Indolylacetic acid; Kyselina 3-indolyloctova; Rhizopin; Rhizopon A; Skatole carboxylate; Skatole carboxylic acid; alpha-Indol-3-yl-acetic acid;  b-Indoleacetate; b-Indoleacetic acid; b-Indolylacetate; b-Indolylacetic acid; beta-Indole-3-acetic acid; beta-Indoleacetate; beta-Indoleacetic acid; beta-Indolylacetate; beta-Indolylacetic acid

# Chemical_IUPAC_Name:
2-(1H-indol-3-yl)acetic acid

# Chemical_Formula:
C10H9NO2

# Chemical_Structure:
tbl_chemical:::HMDB00197_ZOOM.png:::119283247757861178

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00197_THUMB.png:::119283247563830981

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Nitrogenous Compounds; Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
carboxylic acid; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
175.06332

# Molecular_Weight_Avg:
175.18396

# Smiles_String_isomeric:
OC(=O)CC1=CC2=C(N1)C=CC=C2

# Smiles_String_canonical:
OC(=O)CC1=CC2=C(N1)C=CC=C2

# KEGG_Compound_ID:
C00954

# BioCyc_ID:
Not Available

# PubChem_CID:
802

# PubChem_SID:
8137827; 10404740; 10537284; 70220; 8143573; 4205; 4730623; 11385026; 3133538; 7852230; 841420; 149893; 8150798; 604352; 11537205; 7989623

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
1485312

# Wikipedia_ID:
Indoleacetic acid

# METLIN_ID:
5211

# Ref_ID:
12589387; 7508830; 133735; 7679905; 8087979; 1033074; 925688; 1689378; 11568091; 11453733; 6156444; 1180737; 12564839; 7513511; 15184706; 455840; 9505884; 11462886; 3500530; 16150345

# ChEBI_ID:
16411

# CAS_Registry_Number:
87-51-4

# InChI:
InChI=1/C10H9NO2/c12-10(13)6-8-5-7-3-1-2-4-9(7)11-8/h1-5,11H,6H2,(H,12,13)

# Synthesis_Reference:
Preparation of 3-indoleacetic acid; new synthesis of tryptophol.     Snyder, H. R.; Pilgrim, Frederick J.    Journal of the American Chemical Society  (1948),  70  3770-1.

# Melting_Point:
168.5 oC

# Melting_Point_predicted:
114.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1.5 mg/mL [SHIU,WY et al.(1990)]

# H2O_Solubility_Predicted:
1.24 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
1.41 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
1.78 [Predicted by ALOGPS]; 1.5 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Indol-3-ylacetic Acid.pdf; Indoleacetic acid.htm:::113256221513013138

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Indoleacetic_acid.mol:::1132723813406860959

# SDF_File_[Text]:
tbl_chemical:::HMDB00197.sdf:::119283247252387375

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00197.pdb:::119283247426528777

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041002_P00_06_HW_1DP_PRESAT_expanded_2.gif:::114460741664855964

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041002_P00_06_HW_1DP_presat.zip:::1177710550304137043

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041002_P00_06_HW_1DP_Assigned.png:::114660776041139877

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041002_P00_06_HW_2DHSQC_67.png:::114805812206271242

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041002_P00_06_HW_2DHSQC_67.zip:::114805812206761895

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041002_P00_06_HW_2DHSQC_67_Assigned.png:::116499748182047773

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Indoleacetic Acid.gif:::1132732121203745467

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00197_peaks.txt:::1156309612500159161

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Indoleacetic Acid_C.gif:::113273772033831520

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00197_peaks.txt:::1156310801760239244

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00197L.png:::117555262872085596; Medium Energy:tbl_ms:::HMDB00197M.png:::117555268138033367; High Energy:tbl_ms:::HMDB00197H.png:::117555271554537200

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000177.png:::116907444407885047

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000177.txt:::116907444407841028

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000177.png:::116890830212543906

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000177.txt:::116890830239064281

# Cellular_Location:
Cytoplasm; mitochondria

# Tissue_Location:
Brain; Central Nervous System; Fibroblasts; Hippocampus; Hypothalamus; Liver; Platelet; Spinal Cord; Striatum

# deuterated:
No

# Biofluid_Location:
Amniotic Fluid; Blood; Synovial Fluid; Urine

# Concentration_[Normal]:
Urine	5.2	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	8087979
Urine	4.6	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	8087979
Urine	3.4	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	2.8	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	3.8	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	8087979
Urine	5.6 (5.5 - 5.8)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9505884
Blood	< 0.118	uM	Adult:>18_yrs_old	Both	Normal	12564839
Blood	< 0.1	uM	Adult:>18_yrs_old	Both	Normal	11568091


# Concentration_[Abnormal]:
Urine	3.0 (2.5-6.8)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Irritable bowel syndrome (IBS)	
Urine	3.1 +/- 0.14	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Acute Appendicitis	11462886
Urine	2.5 +/- 0.22	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Peritonitis	16150345
Blood	6.7	uM	Adult:>18_yrs_old	Both	Carcinoid	11568091
N/A	3.5 +/- .33	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Acute Appendicitis	


# Associated_Disorders:
Acute Appendicitis; Cachexia; Carcinoid; Irritable bowel syndrome (IBS); Peritonitis

# Pathway_Names:
Lysine degradation;Glycolysis;Fatty acid metabolism;Bile acid biosynthesis;Valine, leucine and isoleucine degradation;Glycerolipid metabolism;Pyruvate metabolism;Propanoate metabolism;Butanoate metabolism;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
Lysine_degradation.jpg;Glycolysis.jpg;;;valine,leucine,and_isoleucine_degradation.jpg;;;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00310;map00010;map00071;map00120;map00280;map00561;map00620;map00640;map00650;map00280;map00280

# Pathway_Graphs:
Lysine_degradation_Graph.jpg;Glycolysis_Graph.jpg;;;valine,leucine,and_isoleucine_degradation_Graph.jpg;;;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
Lysine_degradation.xml;Glycolysis.xml;;;valine,leucine,and_isoleucine_degradation.xml;;;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5526

# Metabolic_Enzyme_1_Name:
4-trimethylaminobutyraldehyde dehydrogenase

# Metabolic_Enzyme_1_Synonyms:
TMABADH; Aldehyde dehydrogenase 9A1; Aldehyde dehydrogenase E3 isozyme; Gamma-aminobutyraldehyde dehydrogenase; R- aminobutyraldehyde dehydrogenase

# Metabolic_Enzyme_1_Gene_Name:
ALDH9A1

# Metabolic_Enzyme_1_Protein_Sequence:
>4trimethylaminobutyraldehyde dehydrogenase
MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA
AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY
AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK
PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI
MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI
LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY
VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA
AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL
KTVCVEMGDVESAF

# Metabolic_Enzyme_1_Number_of_Residues:
494

# Metabolic_Enzyme_1_Molecular_Weight:
53802

# Metabolic_Enzyme_1_Theoretical_pI:
5.61

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction

# Metabolic_Enzyme_1_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_1_Reaction:
4-trimethylammoniobutanal + NAD+ = 4-trimethylammoniobutanoate + NADH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.2.1.47;EC 1.2.1.3;EC

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1049219

# Metabolic_Enzyme_1_SwissProt_ID:
AL9A1_HUMAN (P49189)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ALDH9A1

# Metabolic_Enzyme_1_Geneatlas_id:
ALDH9A1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:412

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1482 bp
ATGAGCACTGGCACCTTCGTCGTGTCGCAGCCGCTCAATTACCGCGGCGGGGCCGCTGGA
GCCGGCGGACGCTCCGGTACCGAGAAAGCTTTCGAGCCAGCAACCGGCCGAGTGATAGCT
ACTTTCACATGTTCAGGAGAAAAGGAAGTAAATTTGGCTGTTCAAAATGCAAAGGCTGCT
TTTAAAATATGGAGTCAAAAATCTGGCATGGAGCGTTGCCGAATCCTTTTGGAGGCTGCC
AGGATAATAAGGGAACGGGAGGATGAAATTGCTACTATGGAGTGCATCAACAATGGCAAG
TCCATCTTTGAGGCCCGCTTGGACATTGACATTTCCTGGCAGTGCCTGGAGTATTATGCG
GGCTTGGCTGCATCCATGGCTGGTGAACACATCCAGCTCCCAGGTGGATCGTTTGGTTAT
ACCAGAAGAGAACCACTTGGGGTATGTGTGGGAATAGGAGCATGGAACTACCCCTTTCAG
ATTGCCTCTTGGAAGTCGGCTCCAGCATTAGCCTGTGGTAATGCCATGGTCTTTAAACCT
TCTCCCTTTACACCTGTTTCTGCATTGCTACTGGCTGAAATCTACAGTGAGGCTGGTGTA
CCTCCTGGGCTCTTCAATGTGGTGCAGGGAGGGGCTGCCACAGGCCAGTTTCTGTGTCAG
CATCCCGATGTGGCCAAAGTCTCCTTCACTGGAAGTGTGCCCACTGGCATGAAGATCATG
GAGATGTCAGCTAAAGGAATCAAACCTGTTACCTTGGAACTTGGAGGCAAATCTCCACTC
ATCATCTTCTCAGACTGTGATATGAACAATGCTGTAAAGGGGGCGCTGATGGCCAACTTC
CTCACACAAGGCCAGGTTTGCTGTAATGGCACAAGAGTATTTGTGCAGAAAGAAATTCTT
GATAAATTTACAGAGGAAGTGGTGAAACAGACCCAAAGGATTAAAATTGGAGATCCCCTT
CTGGAAGATACAAGGATGGGTCCACTCATCAACCGACCACACCTGGAGCGAGTCCTTGGG
TTTGTCAAAGTGGCAAAGGAGCAGGGTGCTAAAGTGTTATGTGGTGGAGATATATATGTA
CCTGAAGATCCCAAATTAAAGGATGGATATTACATGAGACCTTGTGTATTAACTAATTGC
AGAGACGACATGACCTGTGTGAAGGAAGAGATCTTTGGGCCTGTTATGTCCATTTTATCA
TTTGACACTGAAGCTGAGGTTCTAGAAAGAGCCAATGATACCACTTTTGGACTAGCAGCT
GGCGTCTTTACCAGGGACATCCAACGGGCTCATAGAGTGGTAGCTGAGCTTCAGGCTGGG
ACGTGCTTCATTAACAACTATAACGTCAGCCCAGTGGAGTTGCCCTTTGGTGGATATAAG
AAGTCAGGATTTGGCAGAGAGAACGGCCGTGTGACAATCGAATATTATTCACAGCTGAAG
ACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U34252

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_1_Locus:
1q23.1

# Metabolic_Enzyme_1_SNPs:
rs1065756; rs11808728; rs1143659; rs11506; rs12670; rs12408101; rs1913844; rs2882006; rs10753688; rs4646891; rs4646889; rs7516126; rs12565874; rs3820362; rs10800129; rs10800128; rs7534437; rs12072634; rs4656457; rs1337442; rs2348728; rs4578194; rs12080699; rs7541817; rs10918239; rs2348727; rs3738192; rs6683969; rs12065621; rs2348734; rs16849230; rs6426930; rs12083232; rs7513998; rs12122497; rs7555787; rs4646886; rs10800127; rs10918252; rs2348729; rs4646883; rs7518869; rs10800133; rs2176151; rs4646882; rs1538115; rs10800131; rs4646897; rs6690818; rs2050619; rs10753689; rs7546084; rs12076579; rs17482717; rs4657463; rs10918235; rs11587760; rs4274037; rs12567331; rs4557947; rs1337443; rs10800130; rs10800132; rs4646895; rs16849238; rs17450889; rs12033254; rs12069198; rs6657651; rs10918245; rs3845537; rs10918237; rs11807857; rs11807866; rs884121; rs4657462; rs10918236; rs7543204; rs2184918; rs12070650; rs17417191; rs9970857; rs6662419; rs7367737; rs10918242; rs10918241; rs7546322; rs4646888; rs16849374; rs12409168; rs12037790; rs10918247; rs7537071; rs12084748; rs10918238; rs7368130; rs2348730; rs10918244; rs4233407; rs12123278; rs4646892; rs4657466; rs4576644; rs6683651; rs6667075; rs12021795; rs6683665; rs12081464; rs7546215; rs7519162; rs10918240; rs6667088; rs6669697; rs12081903; rs4646885; rs7542184; rs16849479; rs4646887; rs12072664; rs10753687; rs4646896; rs10157944; rs6668102; rs3753893; rs4657468; rs3753892; rs7553712; rs7511691; rs7554409; rs7544840; rs6426928; rs6667681; rs4646881; rs1415503; rs11555775; rs9164; rs4646902; rs6667510; rs11555774; rs4307543; rs11436915; rs34948330; rs12139219; rs34495301; rs10918248; rs1890080; rs35894201; rs4646884; rs28759374; rs12137604; rs28589393; rs34662022; rs12354157; rs10918246; rs35087657; rs34105906; rs35913333; rs34664103; rs12083492; rs2271658; rs34872122; rs7512816; rs4646893; rs7527514; rs12566251; rs1970286; rs3831954; rs2348731; rs10918249; rs35178491; rs36027739; rs35864611; rs17416948; rs4646894; rs11583089; rs12742656; rs12754903; rs12742657; rs41267568; rs4646890; rs12084651; rs4646900; rs34304173; rs13376536; rs12727801; rs41326750; rs28439296; rs12134617; rs12036561; rs35531113; rs3845536; rs36011778; rs12090132; rs7525102; rs10918250; rs3738191; rs12239517; rs4646898; rs34072474; rs34945812; rs10918251; rs1890079; rs35439339; rs36150573; rs1577847; rs12728137; rs34846458; rs4646901; rs36110991; rs12083091; rs34894576; rs6426927; rs11458950; rs1856143; rs35757606; rs41267564; rs41267566; rs35742388; rs10494446; rs10494447; rs10800123; rs10800125; rs10800126; rs10800135; rs10800136; rs10918228; rs10918229; rs10918231; rs10918254; rs10918255; rs10918256; rs11579160; rs11800476; rs11810856; rs12027066; rs12028588; rs12043815; rs12044709; rs12060366; rs12143472; rs12748251; rs1547725; rs16848876; rs16848958; rs16849041; rs16849616; rs1878074; rs1878075; rs2090281; rs2297762; rs2297763; rs2297764; rs2297765; rs3753894; rs3795540; rs4147602; rs4147604; rs4147605; rs4147610; rs4147611; rs4341347; rs7527279; rs7549511; rs7551594; rs8133; rs9333483; rs9333487; rs9919190

# Metabolic_Enzyme_1_General_References:
8786138; 10702312; 8645224; 8269919; 2925663

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5527

# Metabolic_Enzyme_2_Name:
Aldehyde dehydrogenase, dimeric NADP-preferring

# Metabolic_Enzyme_2_Synonyms:
ALDH class 3; ALDHIII

# Metabolic_Enzyme_2_Gene_Name:
ALDH3A1

# Metabolic_Enzyme_2_Protein_Sequence:
>Aldehyde dehydrogenase, dimeric NADPpreferring
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH

# Metabolic_Enzyme_2_Number_of_Residues:
453

# Metabolic_Enzyme_2_Molecular_Weight:
50380

# Metabolic_Enzyme_2_Theoretical_pI:
6.52

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes

# Metabolic_Enzyme_2_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_2_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
178402

# Metabolic_Enzyme_2_SwissProt_ID:
AL3A1_HUMAN (P30838)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ALDH3A1

# Metabolic_Enzyme_2_Geneatlas_id:
ALDH3A1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:405

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1362 bp
ATGAGCAAGATCAGCGAGGCCGTGAAGCGCGCCCGCGCCGCCTTCAGCTCGGGCAGGACC
CGTCCGCTGCAGTTCCGATTCCAGCAGCTGGAGGCGCTGCAGCGCCTGATCCAGGAGCAG
GAGCAGGAGCTGGTGGGCGCGCTGGCCGCAGACCTGCACAAGAATGAATGGAACGCCTAC
TATGAGGAGGTGGTGTACGTCCTAGAGGAGATCGAGTACATGATCCAGAAGCTCCCTGAG
TGGGCCGCGGATGAGCCCGTGGAGAAGACGCCCCAGACTCAGCAGGACGAGCTCTACATC
CACTCGGAGCCACTGGGCGTGGTCCTCGTCATTGGCACCTGGAACTACCCCTTCAACCTC
ACCATCCAGCCCATGGTGGGCGCCATCGCTGCAGGGAACGCAGTGGTCCTCAAGCCCTCG
GAGCTGAGTGAGAACATGGCGAGCCTGCTGGCTACCATCATCCCCCAGTACCTGGACAAG
GATCTGTACCCAGTAATCAATGGGGGTGTCCCTGAGACCACGGAGCTGCTCAAGGAGAGG
TTCGACCATATCCTGTACACGGGCAGCACGGGGGTGGGGAAGATCATCATGACGGCTGCT
GCCAAGCACCTGACCCCTGTCACGCTGGAGCTGGGAGGGAAGAGTCCCTGCTACGTGGAC
AAGAACTGTGACCTGGACGTGGCCTGCCGACGCATCGCCTGGGGGAAATTCATGAACAGT
GGCCAGACCTGCGTGGCCCCAGACTACATCCTCTGTGACCCCTCGATCCAGAACCAAATT
GTGGAGAAGCTCAAGAAGTCACTGAAAGAGTTCTACGGGGAAGATGCTAAGAAATCCCGG
GACTATGGAAGAATCATTAGTGCCCGGCACTTCCAGAGGGTGATGGGCCTGATTGAGGGC
CAGAAGGTGGCTTATGGGGGCACCGGGGATGCCGCCACTCGCTACATAGCCCCCACCATC
CTCACGGACGTGGACCCCCAGTCCCCGGTGATGCAAGAGGAGATCTTCGGGCCTGTGCTG
CCCATCGTGTGCGTGCGCAGCCTGGAGGAGGCCATCCAGTTCATCAACCAGCGTGAGAAG
CCCCTGGCCCTCTACATGTTCTCCAGCAACGACAAGGTGATTAAGAAGATGATTGCAGAG
ACATCCAGTGGTGGGGTGGCGGCCAACGATGTCATCGTCCACATCACCTTGCACTCTCTG
CCCTTCGGGGGCGTGGGGAACAGCGGCATGGGATCCTACCATGGCAAGAAGAGCTTCGAG
ACTTTCTCTCACCGCCGCTCTTGCCTGGTGAGGCCTCTGATGAATGATGAAGGCCTGAAG
GTCAGATACCCCCCGAGCCCGGCCAAGATGACCCAGCACTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M74542

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_2_Locus:
17p11.2

# Metabolic_Enzyme_2_SNPs:
rs887241; rs2228100; rs3744692; rs2072330; rs4646787; rs1042183; rs917520; rs4646789; rs4646788; rs3786036; rs887240; rs2072329; rs4646790; rs3744693; rs9895030; rs3826507; rs3744695; rs3744694; rs2072328; rs1006556; rs4319825; rs1042172; rs11554977; rs11554978; rs11554975; rs11554974; rs34474118; rs3786037; rs35473971; rs4646792; rs35116940; rs4646791; rs35853488; rs887239; rs28531080; rs7216299; rs35009373; rs3786035; rs11385990; rs35308039; rs35128135; rs35885485; rs28552545; rs34438543; rs1006553; rs11650088; rs11651480; rs11870332; rs12948881; rs12949049; rs12951039; rs16960382; rs16960386; rs17793620; rs1989379; rs2016823; rs2052052; rs2072327; rs2108967; rs3760485; rs3760486; rs3760487; rs4646783; rs4646784; rs4646785; rs4646786; rs4924793; rs4925046; rs7214841; rs7221211; rs7225305; rs8075157; rs9898715; rs9900430

# Metabolic_Enzyme_2_General_References:
1737758; 8493892; 2037078; 9250352

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5528

# Metabolic_Enzyme_3_Name:
Alpha-aminoadipic semialdehyde dehydrogenase

# Metabolic_Enzyme_3_Synonyms:
Alpha-AASA dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenease; P6c dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1

# Metabolic_Enzyme_3_Gene_Name:
ALDH7A1

# Metabolic_Enzyme_3_Protein_Sequence:
>Alphaaminoadipic semialdehyde dehydrogenase
MSTLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADY
EETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQ
EYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIA
MICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVN
LLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQ
RCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEA
KKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWN
NEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRES
GSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ

# Metabolic_Enzyme_3_Number_of_Residues:
511

# Metabolic_Enzyme_3_Molecular_Weight:
55367

# Metabolic_Enzyme_3_Theoretical_pI:
6.86

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H

# Metabolic_Enzyme_3_Pathway:
map00300  Lysine biosynthesis;
 map00310  Lysine degradation

# Metabolic_Enzyme_3_Reaction:
L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.2.1.31

# Metabolic_Enzyme_3_GenBank_ID_Protein:
797410

# Metabolic_Enzyme_3_SwissProt_ID:
AL7A1_HUMAN (P49419)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ALDH7A1

# Metabolic_Enzyme_3_Geneatlas_id:
ALDH7A1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:877

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>1536 bp
ATGTCCACTCTCCTCATCAATCAGCCCCAGTATGCGTGGCTGAAAGAGCTGGGGCTCCGC
GAGGAAAACGAGGGCGTGTATAATGGAAGCTGGGGAGGCCGGGGAGAGGTTATTACGACC
TATTGCCCCGCTAACAACGAGCCAATAGCAAGAGTCCGACAGGCCAGTGTGGCAGACTAT
GAAGAAACTGTAAAGAAAGCAAGAGAAGCATGGAAAATCTGGGCAGATATTCCTGCTCCA
AAACGAGGAGAAATAGTAAGACAGATTGGCGATGCCTTGCGGGAGAAGATCCAAGTACTA
GGAAGCTTGGTGTCTTTGGAGATGGGGAAAATCTTAGTGGAAGGTGTGGGTGAAGTTCAG
GAGTATGTGGATATCTGTGACTATGCTGTTGGTTTATCAAGGATGATTGGAGGACCTATC
TTGCCTTCTGAAAGATCTGGCCATGCACTGATTGAGCAGTGGAATCCCGTAGGCCTGGTT
GGAATCATCACGGCATTCAATTTCCCTGTGGCAGTGTATGGTTGGAACAACGCCATCGCC
ATGATCTGTGGAAATGTCTGCCTCTGGAAAGGAGCTCCAACCACTTCCCTCATTAGTGTG
GCTGTCACAAAGATAATAGCCAAGGTTCTGGAGGACAACAAGCTGCCTGGTGCAATTTGT
TCCTTGACTTGTGGTGGAGCAGATATTGGCACAGCAATGGCCAAAGATGAACGAGTGAAC
CTGCTGTCCTTCACTGGGAGCACTCAGGTGGGAAAACAGGTGGGCCTGATGGTGCAGGAG
AGGTTTGGGAGAAGTCTGTTGGAACTTGGAGGAAACAATGCCATTATTGCCTTTGAAGAT
GCAGACCTCAGCTTAGTTGTTCCATCAGCTCTCTTCGCTGCTGTGGGAACAGCTGGCCAG
AGGTGTACCACTGCGAGGCGACTGTTTATACATGAAAGCATCCATGATGAGGTTGTAAAC
AGACTTAAAAAGGCCTATGCACAGATCCGAGTTGGGAACCCATGGGACCCTAATGTTCTC
TATGGGCCACTCCACACCAAGCAGGCAGTGAGCATGTTTCTTGGAGCAGTGGAAGAAGCA
AAGAAAGAAGGTGGCACAGTGGTCTATGGGGGCAAGGTTATGGATCGCCCTGGAAATTAT
GTAGAACCGACAATTGTGACAGGTCTTGGCCACGATGCGTCCATTGCACACACAGAGACT
TTCGCTCCGATTCTCTATGTCTTTAAATTCAAGAATGAAGAAGAGGTCTTTGCATGGAAT
AATGAAGTAAAACAGGGACTTTCAAGTAGCATCTTTACCAAAGATCTGGGCAGAATCTTT
CGCTGGCTTGGACCTAAAGGATCAGACTGTGGCATTGTAAATGTCAACATTCCAACAAGT
GGGGCTGAGATTGGAGGTGCCTTTGGAGGAGAAAAGCACACTGGTGGTGGCAGGGAGTCT
GGCAGTGATGCCTGGAAACAGTACATGAGAAGGTCTACTTGTACTATCAACTACAGTAAA
GACCTTCCTCTGGCCCAAGGAATCAAGTTTCAGTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
S74728

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_3_Locus:
5q31

# Metabolic_Enzyme_3_SNPs:
rs12514417; rs2306618; rs2775; rs1038381; rs6595719; rs4835912; rs1038378; rs1038380; rs2306617; rs4379190; rs4836276; rs11241901; rs4240406; rs12513847; rs7709115; rs4836272; rs7713264; rs6870785; rs11241902; rs7714044; rs1038379; rs10050642; rs7723008; rs4836277; rs3734175; rs6898430; rs17154671; rs4626334; rs13182402; rs17154679; rs4835914; rs12653605; rs2306619; rs7719675; rs10478743; rs7700981; rs2035472; rs11241903; rs6861395; rs7724875; rs2291295; rs10519915; rs7719712; rs6898559; rs4626335; rs17154676; rs11952752; rs13179664; rs4835913; rs11742214; rs3734174; rs11742381; rs7736031; rs7737529; rs10478744; rs4836275; rs17154666; rs34241005; rs10043987; rs7718426; rs2013986; rs10067785; rs7719091; rs17165056; rs13188450; rs900645; rs7708281; rs7703958; rs7723494; rs10050872; rs7702811; rs13171814; rs6897789; rs13177576; rs7704283; rs4526102; rs11741551; rs10038571; rs4836273; rs3736174; rs3736171; rs1483780; rs900641; rs744722; rs900640; rs7718710; rs1060856; rs744720; rs17165061; rs744721; rs1807; rs6865317; rs6884473; rs7447092; rs3189320; rs1049217; rs1049211; rs11542969; rs1049214; rs11269202; rs6898845; rs35027610; rs35284915; rs34275373; rs35570062; rs34674137; rs28429591; rs7730016; rs4612066; rs36058537; rs2408702; rs11406545; rs1142071; rs13356526; rs35492150; rs34697893; rs10539406; rs34825424; rs7703752; rs12187161; rs34949719; rs36125577; rs36077292; rs7719949; rs35736560; rs34201518; rs33926729; rs34250591; rs13185811; rs34323751; rs34907915; rs28865092; rs35559498; rs35109136; rs10630162; rs4836274; rs34972014; rs13173864; rs7709981; rs6870070; rs2408703; rs35118533; rs10532390; rs34517958; rs34069611; rs10629966; rs7706009; rs34496788; rs34935903; rs35115612; rs13174679; rs10609859; rs34995966; rs34074703; rs36120385; rs34424711; rs34537297; rs7737783; rs35457522; rs35367836; rs36017518; rs17597559; rs7730933; rs33954485; rs35196030; rs35930104; rs34575294; rs10666972; rs10676689; rs35010266; rs34035179; rs28629815; rs7704352; rs35797169; rs10044223; rs35622239; rs35960414; rs34959052; rs35342756; rs13154789; rs4836278; rs35617751; rs34731336; rs12656014; rs34305021; rs34684581; rs5871220; rs11951146; rs35290920; rs13166319; rs2408633; rs11290126; rs34862437; rs35992646; rs35110442; rs10609860; rs11742868; rs6896807; rs17531712; rs34770295; rs3080835; rs11387172; rs7737256; rs34601459; rs9765047; rs1060857; rs3736172; rs11458774; rs1138001; rs7447380; rs5871218; rs1138005; rs34410568; rs3736173; rs35569843; rs744723; rs5871219; rs34450389; rs34135005; rs3830274; rs11750167; rs1384880; rs17154635; rs2035471; rs2128931; rs2306620; rs2306621; rs2306622; rs2408700; rs28365789; rs3734173; rs4240405; rs4597966; rs4835911; rs4836271; rs6882015; rs730870; rs7715516; rs7726892

# Metabolic_Enzyme_3_General_References:
8088832; 9417906

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5529

# Metabolic_Enzyme_4_Name:
Aldehyde dehydrogenase 1A3

# Metabolic_Enzyme_4_Synonyms:
Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3

# Metabolic_Enzyme_4_Gene_Name:
ALDH1A3

# Metabolic_Enzyme_4_Protein_Sequence:
>Aldehyde dehydrogenase 1A3
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI
CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM
DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW
NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV
GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE
CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK
QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL
KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF
KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP

# Metabolic_Enzyme_4_Number_of_Residues:
512

# Metabolic_Enzyme_4_Molecular_Weight:
56109

# Metabolic_Enzyme_4_Theoretical_pI:
7.29

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system

# Metabolic_Enzyme_4_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_4_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
544482

# Metabolic_Enzyme_4_SwissProt_ID:
AL1A3_HUMAN (P47895)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
ALDH1A3

# Metabolic_Enzyme_4_Geneatlas_id:
ALDH1A3

# Metabolic_Enzyme_4_hgnc_id:
HGNC:409

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_4_Gene_Sequence:
>1539 bp
ATGGCCACCGCTAACGGGGCCGTGGAAAACGGGCAGCCGGACGGGAAGCCGCCGGCCCTG
CCGCGCCCCATCCGCAACCTGGAGGTCAAGTTCACCAAGATATTTATCAACAATGAATGG
CACGAATCCAAGAGTGGGAAAAAGTTTGCTACATGTAACCCTTCAACTCGGGAGCAAATA
TGTGAAGTGGAAGAAGGAGATAAGCCCGACGTGGACAAGGCTGTGGAGGCTGCACAGGTT
GCCTTCCAGAGGGGCTCGCCATGGCGCCGGCTGGATGCCCTGAGTCGTGGGCGGCTGCTG
CACCAGCTGGCTGACCTGGTGGAGAGGGACCGCGCCACCTTGGCCGCCCTGGAGACGATG
GATACAGGGAAGCCATTTCTTCATGCTTTTTTCATCGACCTGGAGGGCTGTATTAGAACC
CTCAGATACTTTGCAGGGTGGGCAGACAAAATCCAGGGCAAGACCATCCCCACAGATGAC
AACGTCGTATGCTTCACCAGGCATGAGCCCATTGGTGTCTGTGGGGCCATCACTCCATGG
AACTTCCCCCTGCTGATGCTGGTGTGGAAGCTGGCACCCGCCCTCTGCTGTGGGAACACC
ATGGTCCTGAAGCCTGCGGAGCAGACACCTCTCACCGCCCTTTATCTCGGCTCTCTGATC
AAAGAGGCCGGGTTCCCTCCAGGAGTGGTGAACATTGTGCCAGGATTCGGGCCCACAGTG
GGAGCAGCAATTTCTTCTCACCCTCAGATCAACAAGATCGCCTTCACCGGCTCCACAGAG
GTTGGAAAACTGGTTAAAGAAGCTGCGTCCCGGAGCAATCTGAAGCGGGTGACGCTGGAG
CTGGGGGGGAAGAACCCCTGCATCGTGTGTGCGGACGCTGACTTGGACTTGGCAGTGGAG
TGTGCCCATCAGGGAGTGTTCTTCAACCAAGGCCAGTGTTGCACGGCAGCCTCCAGGGTG
TTCGTGGAGGAGCAGGTCTACTCTGAGTTTGTCAGGCGGAGCGTGGAGTATGCCAAGAAA
CGGCCCGTGGGAGACCCCTTCGATGTCAAAACAGAACAGGGGCCTCAGATTGATCAAAAG
CAGTTCGACAAAATCTTAGAGCTGATCGAGAGTGGGAAGAAGGAAGGGGCCAAGCTGGAA
TGCGGGGGCTCAGCCATGGAAGACAAGGGGCTCTTCATCAAACCCACTGTCTTCTCAGAA
GTCACAGACAACATGCGGATTGCCAAAGAGGAGATTTTCGGGCCAGTGCAACCAATACTG
AAGTTCAAAAGTATCGAAGAAGTGATAAAAAGAGCGAATAGCACCGACTATGGACTCACA
GCAGCCGTGTTCACAAAAAATCTCGACAAAGCCCTGAAGTTGGCTTCTGCCTTAGAGTCT
GGAACGGTCTGGATCAACTGCTACAACGCCCTCTATGCACAGGCTCCATTTGGTGGCTTT
AAAATGTCAGGAAATGGCAGAGAACTAGGTGAATACGCTTTGGCCGAATACACAGAAGTG
AAAACTGTCACCATCAAACTTGGCGACAAGAACCCCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
U07919

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_4_Locus:
15q26.3

# Metabolic_Enzyme_4_SNPs:
rs3803430; rs2229183; rs1130738; rs14226; rs3803424; rs7045; rs3803426; rs7182089; rs4646690; rs7161860; rs4246328; rs4646688; rs4646668; rs4646670; rs3803428; rs4646671; rs6598396; rs4646675; rs9944290; rs7181897; rs4646684; rs4246323; rs4246327; rs4246329; rs4646674; rs8039374; rs4646678; rs4646653; rs4646655; rs7182884; rs3809521; rs11854028; rs3825926; rs3803433; rs6598397; rs4646662; rs4646685; rs4646651; rs4646672; rs3922685; rs4646654; rs3902902; rs4646683; rs7176046; rs3803432; rs4246324; rs4646661; rs8030776; rs12903828; rs4646687; rs4646680; rs3825925; rs7178221; rs3803427; rs7170197; rs4246325; rs8023972; rs4646681; rs7167278; rs4246326; rs1886; rs4646649; rs12908902; rs7171776; rs3803429; rs12914598; rs4646669; rs4646650; rs3803434; rs4646660; rs4646682; rs3809524; rs3809523; rs3809526; rs7179268; rs1130737; rs3803431; rs1130768; rs34302490; rs28760343; rs35300460; rs1802602; rs1802604; rs4288979; rs3803425; rs1802603; rs4646663; rs28691047; rs28731371; rs34655770; rs35165034; rs28509297; rs10400871; rs35129664; rs12905372; rs28405557; rs34486175; rs28546254; rs35055541; rs4646686; rs28441320; rs28410143; rs4646676; rs4646648; rs8029933; rs12910188; rs34182689; rs28504296; rs28449981; rs28507582; rs3825927; rs35310246; rs12910025; rs28384196; rs4343265; rs12910662; rs8028283; rs28475530; rs4392045; rs28369514; rs28377287; rs8035722; rs28480133; rs28707102; rs28583888; rs4646666; rs7173413; rs28472416; rs28673034; rs28668881; rs28711429; rs34837038; rs4646659; rs28452487; rs28712665; rs12910029; rs12902704; rs4646673; rs28689536; rs28431101; rs34431941; rs7178645; rs28454526; rs7170202; rs1889; rs4646647; rs4375646; rs11348272; rs4646656; rs28408085; rs28699556; rs28615197; rs28539744; rs28557216; rs28631565; rs34302839; rs3923499; rs4646664; rs35740226; rs28385499; rs3922686; rs28474807; rs28490217; rs12909825; rs10593974; rs28679806; rs28610999; rs7178553; rs35519561; rs35831758; rs35526807; rs4646658; rs28538652; rs28685242; rs10400842; rs4646667; rs35948146; rs4646677; rs7165217; rs10400872; rs28750207; rs3825924; rs7171453; rs34906846; rs4646665; rs9920154; rs36081993; rs11435500; rs28464660; rs4646679; rs12595234; rs4646689; rs3809522; rs35950557; rs3809527; rs7172149; rs7178931; rs8034153; rs7183889; rs3809525; rs4646646; rs11630601; rs11630691; rs11632820; rs11637204; rs11854709; rs12148466; rs12148493; rs12440023; rs12593839; rs12901792; rs12907776; rs12908105; rs12909230; rs12909791; rs28507591; rs3803435; rs4346184; rs4646694; rs7163108; rs7164136; rs7181644; rs8034686; rs8035036

# Metabolic_Enzyme_4_General_References:
7698756

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5530

# Metabolic_Enzyme_5_Name:
Aldehyde dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
ALDH class 2; ALDHI; ALDH-E2

# Metabolic_Enzyme_5_Gene_Name:
ALDH2

# Metabolic_Enzyme_5_Protein_Sequence:
>Aldehyde dehydrogenase, mitochondrial precursor
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS

# Metabolic_Enzyme_5_Number_of_Residues:
517

# Metabolic_Enzyme_5_Molecular_Weight:
56382

# Metabolic_Enzyme_5_Theoretical_pI:
7.05

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_5_Specific_Function:
An aldehyde + NAD(+) + H(2)O = an acid + NADH

# Metabolic_Enzyme_5_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_5_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_5_Signals:
1-24

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_5_GenBank_ID_Protein:
28606

# Metabolic_Enzyme_5_SwissProt_ID:
ALDH2_HUMAN (P05091)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ALDH2

# Metabolic_Enzyme_5_Geneatlas_id:
ALDH2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:404

# Metabolic_Enzyme_5_PDB_ID:
1OF7

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_5_Gene_Sequence:
>1551 bp
ATGTTGCGCGCTGCCGCCGCTCGGGCCCCGCCTGGCCGCCGCCTCTTGTCAGCCGCCGCC
ACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTTCATA
AACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACT
GGAGAGGTCATCTGTCAGGTAGCTGAAGGGGACAAGGAAGATGTGGACAAGGCACGTGAA
GGCCGCCCGGGCGCCTTCCAGCTGGGCTCACCTTGGCGCCGCATGGACGCATCACACAGC
GGCCGGCTGCTGAACCGCCTGGCCGATCTGATCGAGCGGGACCGGACCTACCTGGCGGCC
TTGGAGACCCTGGACAATGGCAAGCCCTATGTCATCTCCTACCTGGTGGATTTGGACATG
GTCCTCAAATGTCTCCGGTATTATGCCGGCTGGGCTGATAAGTACCACGGGAAAACCATC
CCCATTGACGGAGACTTCTTCAGCTACACACGCCATGAACCTGTGGGGGTGTGCGGGCAG
ATCATTCCGTGGAATTTCCCGCTCCTGATGCAAGCATGGAAGCTGGGCCCAGCCTTGGCA
ACTGGAAACGTGGTTGTGATGAAGGTAGCTGAGCAGACACCCCTCACCGCCCTCTATGTG
GCCAACCTGATCAAGGAGGCTGGCTTTCCCCCTGGTGTGGTCAACATTGTGCCTGGATTT
GGCCCCACGGCTGGGGCCGCCATTGCCTCCCATGAGGATGTGGACAAAGTGGCATTCACA
GGCTCCACTGAGATTGGCCGCGTAATCCAGGTTGCTGCTGGGAGCAGCAACCTCAAGAGA
GTGACCTTGGAGCTGGGGGGGAAGAGCCCCAACATCATCATGTCAGATGCCGATATGGAT
TGGGCCGTGGAACAGGCCCACTTCGCCCTGTTCTTCAACCAGGGCCAGTGCTGCTGTGCC
GGCTCCCGGACCTTCGTGCAGGAGGACATCTATGATGAGTTTGTGGTGCGGAGCGTTGCC
CGGGCCAAGTCTCGGGTGGTCGGGAACCCCTTTGATAGCAAGACCGAGCAGGGGCCGCAG
GTGGATGAAACTCAGTTTAAGAAGATCCTCGGCTACATCAACACGGGGAAGCAAGAGGGG
GCGAAGCTGCTGTGTGGTGGGGGCATTGCTGCTGACCGTGGTTACTTCATCCAGCCCACT
GTGTTTGGAGATGTGCAGGATGGCATGACCATCGCCAAGGAGGAGATCTTCGGGCCAGTG
ATGCAGATCCTGAAGTTCAAGACCATAGAGGAGGTTGTTGGGAGAGCCAACAATTCCACG
TACGGGCTGGCCGCAGCTGTCTTCACAAAGGATTTGGACAAGGCCAATTACCTGTCCCAG
GCCCTCCAGGCGGGCACTGTGTGGGTCAACTGCTATGATGTGTTTGGAGCCCAGTCACCC
TTTGGTGGCTACAAGATGTCGGGGAGTGGCCGGGAGTTGGGCGAGTACGGGCTGCAGGCA
TACACTGAAGTGAAAACTGTCACAGTCAAAGTGCCTCAGAAGAACTCATAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X05409

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_5_Locus:
12q24.2

# Metabolic_Enzyme_5_SNPs:
rs671; rs1062136; rs6490301; rs886205; rs2238151; rs968529; rs7296651; rs441; rs4767939; rs10744777; rs4646778; rs4767944; rs10849970; rs2158029; rs4646776; rs7312055; rs7311852; rs2238152; rs4646777; rs2283354; rs10774637; rs4648328; rs10774638; rs11609628; rs11066028; rs4646779; rs16941669; rs440; rs7397491; rs11834780; rs16941667; rs4646775; rs11066029; rs35154896; rs11066024; rs2106696; rs11613231; rs2158028; rs4767035; rs13306166; rs34083959; rs7136890; rs13306164; rs1064933; rs34477327; rs34884061; rs28633753; rs11442381; rs11615695; rs11066023; rs35511855; rs35781311; rs13306163; rs7397456; rs35050853; rs35642129; rs12312867; rs12829533; rs11407827; rs34480430; rs12314397; rs35264878; rs12813835; rs12322000; rs34896918; rs35650885; rs7970477; rs11066025; rs13306167; rs11066027; rs12301347; rs11614684; rs35700215; rs35746295; rs34587287; rs13306165; rs35786282; rs11066022; rs7397469; rs11066030; rs10450717; rs35693865; rs11503169; rs35546929; rs33973376; rs34497874; rs12830829; rs35061167; rs11609093; rs36073646; rs34108639; rs12824249; rs11610258; rs35147079; rs11613713; rs11066026; rs7486832; rs12099590; rs3832868; rs34300515; rs35212101; rs7398472; rs35239056; rs35752199; rs5800933; rs11613351; rs5023470; rs34587619; rs4646781; rs4646780; rs11304348; rs12305979; rs4646782; rs10849969; rs10849971; rs11066032; rs14630; rs2339839; rs2339840; rs7133964; rs737280; rs739580; rs7974339; rs7978737; rs9971942

# Metabolic_Enzyme_5_General_References:
3582651; 3562250; 2838413; 4065146; 2987944; 4015823; 3610592; 3653404; 6582480; 8561277; 10631996

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5531

# Metabolic_Enzyme_6_Name:
Fatty aldehyde dehydrogenase

# Metabolic_Enzyme_6_Synonyms:
Aldehyde dehydrogenase, microsomal; Aldehyde dehydrogenase family 3 member A2; Aldehyde dehydrogenase 10

# Metabolic_Enzyme_6_Gene_Name:
ALDH3A2

# Metabolic_Enzyme_6_Protein_Sequence:
>Fatty aldehyde dehydrogenase
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE
VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ
PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH
IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT
CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI
AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA
LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS
HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV
KAEYY

# Metabolic_Enzyme_6_Number_of_Residues:
485

# Metabolic_Enzyme_6_Molecular_Weight:
54849

# Metabolic_Enzyme_6_Theoretical_pI:
7.99

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_6_Specific_Function:
Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length

# Metabolic_Enzyme_6_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_6_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
464-480

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_6_GenBank_ID_Protein:
1082036

# Metabolic_Enzyme_6_SwissProt_ID:
AL3A2_HUMAN (P51648)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ALDH3A2

# Metabolic_Enzyme_6_Geneatlas_id:
ALDH3A2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:403

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein; cytoplasmic side

# Metabolic_Enzyme_6_Gene_Sequence:
>1458 bp
ATGGAGCTCGAAGTCCGGCGGGTCCGACAGGCGTTCCTGTCCGGCCGGTCGCGACCTCTG
CGGTTTCGGCTGCAGCAGCTGGAGGCCCTGCGGAGGATGGTGCAGGAGCGCGAGAAGGAT
ATCCTGACGGCCATCGCCGCCGACCTGTGCAAGAGTGAATTCAATGTGTACAGTCAGGAA
GTCATTACTGTCCTTGGGGAAATTGATTTTATGCTTGAGAATCTTCCTGAATGGGTTACT
GCTAAACCAGTTAAGAAGAACGTGCTCACCATGCTGGATGAGGCCTATATTCAGCCACAG
CCTCTGGGAGTGGTGCTGATAATCGGAGCTTGGAATTACCCCTTCGTTCTCACCATTCAG
CCACTGATAGGAGCCATCGCTGCAGGAAATGCTGTGATTATAAAGCCTTCTGAACTGAGT
GAAAATACAGCCAAGATCTTGGCAAAGCTTCTCCCTCAGTATTTAGACCAGGATCTCTAT
ATTGTTATTAATGGTGGTGTTGAGGAAACCACGGAGCTCCTGAAGCAGCGATTTGACCAC
ATTTTCTATACGGGAAACACTGCGGTTGGCAAAATTGTCATGGAAGCTGCTGCCAAGCAT
CTGACCCCTGTGACTCTTGAACTGGGAGGGAAAAGTCCATGTTATATTGATAAAGATTGT
GACCTGGACATTGTTTGCAGACGCATAACCTGGGGAAAATACATGAATTGTGGCCAAACC
TGCATTGCACCCGACTATATTCTCTGTGAAGCATCCCTCCAAAATCAAATTGTATGGAAG
ATTAAGGAAACAGTGAAGGAATTTTATGGAGAAAATATAAAAGAGTCTCCTGATTATGAA
AGGATCATCAATCTTCGTCATTTTAAGAGGATACTAAGTTTGCTTGAAGGACAAAAGATA
GCTTTTGGTGGGGAGACTGATGAGGCCACACGCTACATAGCCCCAACAGTACTTACCGAT
GTTGATCCTAAAACCAAGGTGATGCAAGAAGAAATTTTTGGACCAATTCTTCCAATAGTG
CCTGTGAAAAATGTAGATGAGGCCATAAATTTCATAAATGAACGTGAAAAGCCTCTGGCT
CTTTATGTATTTTCGCATAACCATAAGCTCATCAAACGGATGATTGATGAGACATCCAGT
GGAGGTGTCACAGGCAATGACGTCATTATGCACTTCACGCTCAACTCTTTCCCATTTGGA
GGAGTGGGTTCCAGTGGGATGGGAGCTTATCACGGAAAACATAGTTTTGATACTTTTTCT
CATCAGCGTCCCTGTTTATTAAAAAGTTTAAAGAGAGAAGGTGCTAACAAACTCAGATAT
CCTCCCAACAGCCAGTCAAAGGTGGATTGGGGGAAATTTTTTCTCTTGAAACGGTTCAAC
AAAGAAAAACTCGGTCTCCTGTTGCTCACTTTCCTGGGTATTGTAGCCGCTGTGCTTGTC
AAGGCAGAATATTACTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
L47162

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_6_Locus:
17p11.2

# Metabolic_Enzyme_6_SNPs:
rs7216; rs7503517; rs7215; rs16420; rs11204408; rs3786038; rs962801; rs2072333; rs1034897; rs2072331; rs2108971; rs1004490; rs1004491; rs4244600; rs962800; rs8069576; rs4925036; rs2072332; rs16960280; rs4646797; rs8069478; rs2386145; rs1800869; rs11204407; rs4646798; rs4646794; rs4925038; rs4646800; rs4925037; rs4646795; rs4646804; rs4646802; rs8073767; rs12937946; rs9910300; rs4646801; rs9901895; rs1034896; rs3760489; rs4621031; rs3888642; rs1057405; rs11548343; rs12947169; rs34160909; rs35364675; rs7209322; rs35495378; rs12947168; rs12708; rs4646805; rs7215552; rs35965955; rs2386146; rs35716578; rs34082599; rs4646799; rs4646796; rs3034928; rs1800870; rs35581449; rs5819686; rs34567842; rs34350257; rs34642385; rs4646793; rs11652177; rs4646907; rs34471504; rs8073053; rs2386147; rs6146012; rs34945824; rs36031953; rs34327718; rs35797108; rs34664206; rs4646803; rs35265843; rs36025724; rs35053333; rs3841513; rs34368630; rs4646806; rs35604266; rs16960266; rs28375263; rs11868363; rs11871420; rs11871642; rs12937179; rs1804608; rs2386144; rs34399035; rs34416664; rs35526408; rs4646807; rs4925026; rs8065688; rs8074204; rs8074500

# Metabolic_Enzyme_6_General_References:
8528251; 9027499; 9070922; 9254849; 9829906

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5532

# Metabolic_Enzyme_7_Name:
Aldehyde dehydrogenase X, mitochondrial precursor

# Metabolic_Enzyme_7_Synonyms:
Aldehyde dehydrogenase family 1 member B1; ALDH class 2

# Metabolic_Enzyme_7_Gene_Name:
ALDH1B1

# Metabolic_Enzyme_7_Protein_Sequence:
>Aldehyde dehydrogenase X, mitochondrial precursor
MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT
TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNLLADLVERDRVYLA
SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCG
QIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITG
YGPTAGAAIAQHMDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADM
EHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGP
QVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP
VQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHT
PFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS

# Metabolic_Enzyme_7_Number_of_Residues:
517

# Metabolic_Enzyme_7_Molecular_Weight:
57239

# Metabolic_Enzyme_7_Theoretical_pI:
6.79

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_7_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation

# Metabolic_Enzyme_7_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_7_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_7_Signals:
1-22

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_7_GenBank_ID_Protein:
1263008

# Metabolic_Enzyme_7_SwissProt_ID:
AL1B1_HUMAN (P30837)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
ALDH1B1

# Metabolic_Enzyme_7_Geneatlas_id:
ALDH1B1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:407

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_7_Gene_Sequence:
>1554 bp
ATGCTGCGCTTCCTGGCACCCCGGCTGCTTAGCCTCCAGGGCAGGACCGCCCTCTACTCC
TCGGCAGCAGCCCTCCCAAGCCCCATTCTGAACCCAGACATCCCCTACAACCAGCTGTTC
ATCAACAATGAATGGCAAGATGCAGTCAGCAAGAAGACCTTCCCGACGGTCAACCCTACC
ACCGGGGAGGTCATCGGGCACGTGGCTGAAGGTGACCGGGCTGATGTGGATCGGGCCGTG
AAAGCAGCCCGGGAAGCCTTCCGCCTGGGGTCCCCATGGCGCCGGATGGATGCCTCTGAG
CGGGGCCGGCTGCTGAACCTCCTGGCAGACCTAGTGGAGCGGGATCGAGTCTACTTGGCC
TCACTCGAGACCTTGGACAATGGGAAGCCTTTCCAAGAGTCTTACGCCTTGGACTTGGAT
GAGGTCATCAAGGTGTATCGGTACTTTGCTGGCTGGGCTGACAAGTGGCATGGCAAGACC
ATCCCCATGCATGGCCAGCATTTCTGCTTCACCCGGCATGAGCCCGTTGGTGTCTGTGGC
CAGATCATCCCGTGGAACTTCCCCTTGGTCATGCAGGGTTGGAAACTTGCCCCGGCACTC
GCCACAGGCAACACTGTGGTTATGAAGGTGGCAGAGCAGACCCCCCTCTCTGCCCTGTAT
TTGGCCTCCCTCATCAAGGAGGCAGGCTTTCCCCCTGGGGTGGTGAACATCATCACGGGG
TATGGCCCAACAGCAGGTGCGGCCATCGCCCAGCACATGGATGTTGACAAAGTTGCCTTC
ACCGGTTCCACCGAGGTGGGCCACCTGATCCAGAAAGCAGCTGGCGATTCCAACCTCAAG
AGAGTCACCCTGGAGCTGGGTGGTAAGAGCCCCAGCATCGTGCTGGCCGATGCTGACATG
GAGCATGCCGTGGAGCAGTGCCACGAAGCCCTGTTCTTCAACATGGGCCAGTGCTGCTGT
GCTGGCTCCCGGACCTTCGTGGAAGAATCCATCTACAATGAGTTTCTCGAGAGAACCGTG
GAGAAAGCAAAGCAGAGGAAAGTGGGGAACCCCTTTGAGCTGGACACCCAGCAGGGGCCT
CAGGTGGACAAGGAGCAGTTTGAACGAGTCCTAGGCTACATCCAGCTTGGCCAGAAGGAG
GGCGCAAAACTCCTCTGTGGCGGAGAGCGTTTCGGGGAGCGTGGTTTCTTCATCAAGCCT
ACTGTCTTTGGTGGCGTGCAGGATGACATGAGAATTGCCAAAGAGGAGATCTTTGGGCCT
GTGCAGCCCCTGTTCAAGTTCAAGAAGATTGAGGAGGTGGTTGAGAGGGCCAACAACACC
AGGTATGGCCTGGCTGCGGCTGTGTTCACCCGGGATCTGGACAAGGCCATGTACTTCACC
CAGGCACTCCAGGCCGGGACCGTGTGGGTAAACACCTACAACATCGTCACCTGCCACACG
CCATTTGGAGGGTTTAAGGAATCTGGAAACGGGAGGGAGCTGGGTGAGGATGGGCTTAAG
GCCTACACAGAGGTAAAGACGGTCACCATCAAGGTTCCTCAGAAGAACTCGTAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
M63967

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_7_Locus:
9p11.1

# Metabolic_Enzyme_7_SNPs:
rs2228093; rs4878199; rs2073478; rs2073477; rs2228094; rs3043; rs6476701; rs10758494; rs10758495; rs7859877; rs4646772; rs4646774; rs4878802; rs10738997; rs11555705; rs4646773; rs41278335; rs11555706; rs10973781; rs10973782; rs12343271; rs41278337; rs10118683; rs10758496; rs10814687; rs10973774; rs10973779; rs10973783; rs10973785; rs10973786; rs10973787; rs10973789; rs10973792; rs11361; rs11790480; rs11791018; rs11791622; rs12001093; rs12336048; rs12352007; rs12378762; rs13285234; rs13290293; rs1555480; rs1923423; rs1923424; rs2038589; rs34183602; rs35950473; rs4142260; rs4242647; rs4878203; rs4878800; rs4878801; rs4878804; rs4878805; rs4878806; rs4878807; rs4878808; rs4878809; rs4878811; rs6476703; rs7021469; rs7031628; rs7045542; rs7046137; rs7853954; rs7865905; rs7866277; rs7867383; rs911757; rs911758

# Metabolic_Enzyme_7_General_References:
2061311; 8244338

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5709

# Metabolic_Enzyme_8_Name:
Tryptophan 5-hydroxylase 1

# Metabolic_Enzyme_8_Synonyms:
Tryptophan 5-monooxygenase 1

# Metabolic_Enzyme_8_Gene_Name:
TPH1

# Metabolic_Enzyme_8_Protein_Sequence:
>Tryptophan 5hydroxylase 1
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI

# Metabolic_Enzyme_8_Number_of_Residues:
444

# Metabolic_Enzyme_8_Molecular_Weight:
50986

# Metabolic_Enzyme_8_Theoretical_pI:
7.23

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  tryptophan 5-monooxygenase activity
Function:  amine binding
Function:  amino acid binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  neurotransmitter metabolism
Process:  neurotransmitter biosynthesis
Process:  serotonin biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
L-tryptophan + tetrahydrobiopterin + O(2) = 5- hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_8_Pathway:
map00380  Tryptophan metabolism

# Metabolic_Enzyme_8_Reaction:
L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF01842:ACT;
PF00351:Biopterin_H

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.14.16.4

# Metabolic_Enzyme_8_GenBank_ID_Protein:
37955

# Metabolic_Enzyme_8_SwissProt_ID:
TPH1_HUMAN (P17752)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
TPH1

# Metabolic_Enzyme_8_Geneatlas_id:
TPH1

# Metabolic_Enzyme_8_hgnc_id:
HGNC:12008

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Not Available

# Metabolic_Enzyme_8_Gene_Sequence:
>1335 bp
ATGATTGAAGACAATAAGGAGAACAAAGACCATTCCTTAGAAAGGGGAAGAGCAAGTCTC
ATTTTTTCCTTAAAGAATGAAGTTGGAGGACTTATAAAAGCCCTGAAAATCTTTCAGGAG
AAGCATGTGAATCTGTTACATATCGAGTCCCGAAAATCAAAAAGAAGAAACTCAGAATTT
GAGATTTTTGTTGACTGTGACATCAACAGAGAACAATTGAATGATATTTTTCATCTGCTG
AAGTCTCATACCAATGTTCTCTCTGTGAATCTACCAGATAATTTTACTTTGAAGGAAGAT
GGTATGGAAACTGTTCCTTGGTTTCCAAAGAAGATTTCTGACCTGGACCATTGTGCCAAC
AGAGTTCTGATGTATGGATCTGAACTAGATGCAGACCATCCTGGCTTCAAAGACAATGTC
TACCGTAAACGTCGAAAGTATTTTGCGGACTTGGCTATGAACTATAAACATGGAGACCCC
ATTCCAAAGGTTGAATTCACTGAAGAGGAGATTAAGACCTGGGGAACCGTATTCCAAGAG
CTCAACAAACTCTACCCAACCCATGCTTGCAGAGAGTATCTCAAAAACTTACCTTTGCTT
TCTAAATATTGTGGATATCGGGAGGATAATATCCCACAATTGGAAGATGTCTCCAACTTT
TTAAAAGAGCGTACAGGTTTTTCCATCCGTCCTGTGGCTGGTTACTTATCACCAAGAGAT
TTCTTATCAGGTTTAGCCTTTCGAGTTTTTCACTGCACTCAATATGTGAGACACAGTTCA
GATCCCTTCTATACCCCAGAGCCAGATACCTGCCATGAACTCTTAGGTCATGTCCCGCTT
TTGGCTGAACCTAGTTTTGCCCAATTCTCCCAAGAAATTGGCTTGGCTTCTCTTGGCGCT
TCAGAGGAGGCTGTTCAAAAACTGGCAACGTGCTACTTTTTCACTGTGGAGTTTGGTCTA
TGTAAACAAGATGGACAGCTAAGAGTCTTTGGTGCTGGCTTACTTTCTTCTATCAGTGAA
CTCAAACATGCACTTTCTGGACATGCCAAAGTAAAGCCCTTTGATCCCAAGATTACCTGC
AAACAGGAATGTCTTATCACAACTTTTCAAGATGTCTACTTTGTATCTGAAAGTTTTGAA
GATGCAAAGGAGAAGATGAGAGAATTTACCAAAACAATTAAGCGTCCATTTGGAGTGAAG
TATAATCCATATACACGGAGTATTCAGATCCTGAAAGACACCAAGAGCATAACCAGTGCC
ATGAATGAGCTGCAGCATGATCTCGATGTTGTCAGTGATGCCCTTGCTAAGGTCAGCAGG
AAGCCGAGTATCTAA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X52836

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_8_Locus:
11p15.3-p14

# Metabolic_Enzyme_8_SNPs:
rs211107; rs172423; rs2056246; rs211105; rs1800532; rs1799913; rs684302; rs508924; rs1607395; rs685657; rs211102; rs10488683; rs10741734; rs211106; rs169806; rs591556; rs17794760; rs10832874; rs7933505; rs211104; rs11606304; rs11575890; rs2237907; rs11024447; rs685247; rs685249; rs11024449; rs10832876; rs17721739; rs500135; rs480425; rs211108; rs623580; rs10488682; rs2108977; rs8176799; rs12098985; rs7129561; rs41274348; rs41274350; rs503964; rs490895; rs7926900; rs34779435; rs35527095; rs34366393; rs35266509; rs10638620; rs593839; rs10658055; rs593414; rs11575863; rs211100; rs11413954; rs502962; rs211101; rs35668313; rs490966; rs34768875; rs592588; rs3216310; rs34651161; rs12279367; rs12279256; rs491779; rs592576; rs34286483; rs34892919; rs34584326; rs10655479; rs211103; rs12279322; rs592536; rs11024448; rs10832875; rs12287062; rs12279255; rs36020452; rs36063783; rs34067973; rs35878128; rs1134530; rs34396122; rs1133758; rs11024454; rs12365674; rs12575070; rs211109; rs3741201; rs3741202; rs4537731; rs521318; rs6486403; rs652458; rs7110238; rs7122118; rs7130929

# Metabolic_Enzyme_8_General_References:
2377472; 7986090; 9751214; 12379098

# Metabolic_Enzyme_8_References:
9928261

# Metabolic_Enzyme_9_ID:
5401

# Metabolic_Enzyme_9_Name:
Amine oxidase [flavin-containing] A

# Metabolic_Enzyme_9_Synonyms:
Monoamine oxidase type A; MAO-A

# Metabolic_Enzyme_9_Gene_Name:
MAOA

# Metabolic_Enzyme_9_Protein_Sequence:
>Amine oxidase flavincontaining 
AMENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEH
VDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPI
AYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVN
INVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVK
LNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLP
MGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKAD
RLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQY
GRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESK
DVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS

# Metabolic_Enzyme_9_Number_of_Residues:
527

# Metabolic_Enzyme_9_Molecular_Weight:
59682

# Metabolic_Enzyme_9_Theoretical_pI:
7.96

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine

# Metabolic_Enzyme_9_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_9_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF01593:Amino_oxidase

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
498-518

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 1.4.3.4

# Metabolic_Enzyme_9_GenBank_ID_Protein:
187353

# Metabolic_Enzyme_9_SwissProt_ID:
AOFA_HUMAN (P21397)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
MAOA

# Metabolic_Enzyme_9_Geneatlas_id:
MAOA

# Metabolic_Enzyme_9_hgnc_id:
HGNC:6833

# Metabolic_Enzyme_9_PDB_ID:
1O5W

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type IV membrane protein; cytoplasmic side

# Metabolic_Enzyme_9_Gene_Sequence:
>1584 bp
ATGGAGAATCAAGAGAAGGCGAGTATCGCGGGCCACATGTTCGACGTAGTCGTGATCGGA
GGTGGCATTTCAGGACTATCTGCTGCCAAACTCTTGACTGAATATGGCGTTAGTGTTTTG
GTTTTAGAAGCTCGGGACAGGGTTGGAGGAAGAACATATACTATAAGGAATGAGCATGTT
GATTACGTAGATGTTGGTGGAGCTTATGTGGGACCAACCCAAAACAGAATCTTACGCTTG
TCTAAGGAGCTGGGCATAGAGACTTACAAAGTGAATGTCAGTGAGCGTCTCGTTCAATAT
GTCAAGGGGAAAACATATCCATTTCGGGGCGCCTTTCCACCAGTATGGAATCCCATTGCA
TATTTGGATTACAATAATCTGTGGAGGACAATAGATAACATGGGGAAGGAGATTCCAACT
GATGCACCCTGGGAGGCTCAACATGCTGACAAATGGGACAAAATGACCATGAAAGAGCTC
ATTGACAAAATCTGCTGGACAAAGACTGCTAGGCGGTTTGCTTATCTTTTTGTGAATATC
AATGTGACCTCTGAGCCTCACGAAGTGTCTGCCCTGTGGTTCTTGTGGTATGTGAAGCAG
TGCGGGGGCACCACTCGGATATTCTCTGTCACCAATGGTGGCCAGGAACGGAAGTTTGTA
GGTGGATCTGGTCAAGTGAGCGAACGGATAATGGACCTCCTCGGAGACCAAGTGAAGCTG
AACCATCCTGTCACTCACGTTGACCAGTCAAGTGACAACATCATCATAGAGACGCTGAAC
CATGAACATTATGAGTGCAAATACGTAATTAATGCGATCCCTCCGACCTTGACTGCCAAG
ATTCACTTCAGACCAGAGCTTCCAGCAGAGAGAAACCAGTTAATTCAGCGGCTTCCAATG
GGAGCTGTCATTAAGTGCATGATGTATTACAAGGAGGCCTTCTGGAAGAAGAAGGATTAC
TGTGGCTGCATGATCATTGAAGATGAAGATGCTCCAATTTCAATAACCTTGGATGACACC
AAGCCTGATGGGTCACTGCCTGCCATCATGGGCTTCATTCTTGCCCGGAAAGCTGATCGA
CTTGCTAAGCTACATAAGGAAATAAGGAAGAAGAAAATCTGTGAGCTCTATGCCAAAGTG
CTGGGATCCCAAGAAGCTTTACATCCAGTGCATTATGAAGAGAAGAACTGGTGTGAGGAG
CAGTACTCTGGGGGCTGCTACACGGCCTACTTCCCTCCTGGGATCATGACTCAATATGGA
AGGGTGATTCGTCAACCCGTGGGCAGGATTTTCTTTGCGGGCACAGAGACTGCCACAAAG
TGGAGCGGCTACATGGAAGGGGCAGTTGAGGCTGGAGAACGAGCAGCTAGGGAGGTCTTA
AATGGTCTCGGGAAGGTGACCGAGAAAGATATCTGGGTACAAGAACCTGAATCAAAGGAC
GTTCCAGCGGTAGAAATCACCCACACCTTCTGGGAAAGGAACCTGCCCTCTGTTTCTGGC
CTGCTGAAGATCATTGGATTTTCCACATCAGTAACTGCCCTGGGGTTTGTGCTGTACAAA
TACAAGCTCCTGCCACGGTCTTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
M68840

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_9_Locus:
Xp11.3

# Metabolic_Enzyme_9_SNPs:
rs6323; rs1137070; rs1800464; rs3027407; rs2072743; rs1465107; rs979605; rs3027397; rs2205718; rs979606; rs909525; rs3788862; rs2283725; rs2235186; rs5906883; rs5906974; rs3027403; rs3027405; rs6520894; rs3027401; rs3788863; rs2235185; rs1465108; rs5953385; rs2310883; rs6609250; rs3027398; rs5906938; rs5906729; rs6520897; rs5906893; rs17146683; rs7885398; rs3027402; rs5905702; rs5906957; rs2072744; rs5906915; rs4824498; rs9723729; rs3027406; rs5906973; rs3027400; rs2064697; rs5906914; rs5906901; rs12689575; rs2239448; rs2064696; rs3027392; rs2238968; rs17146660; rs12688067; rs9723711; rs7051042; rs5905859; rs7887158; rs2064698; rs7882699; rs3027399; rs9330645; rs2283724; rs9723795; rs3027404; rs9724332; rs5953210; rs1803986; rs1799835; rs1800466; rs1803987; rs1800465; rs7065428; rs3027408; rs11544798; rs12839550; rs10545588; rs5952250; rs3027394; rs34390290; rs1800659; rs10560402; rs12854463; rs35759188; rs28375424; rs7059300; rs12687961; rs35784967; rs35254233; rs34894015; rs35215664; rs35546327; rs3027396; rs12556694; rs7057038; rs12687974; rs9780693; rs7892282; rs5902323; rs28593700; rs35600375; rs35488042; rs35200424; rs5902326; rs5905823; rs12843650; rs34941362; rs34841794; rs12833632; rs12863636; rs3030071; rs12398290; rs10548364; rs28401570; rs4604608; rs28449781; rs6609256; rs6610845; rs12833929; rs12843268; rs2310884; rs5905830; rs6610846; rs7054032; rs7880230; rs41303697; rs3810709; rs2179098; rs12399572; rs12840448; rs5902324; rs28556796; rs5905812; rs12847449; rs28619059; rs10652560; rs6610837; rs10548363; rs5905418; rs2283726; rs33910552; rs3027395; rs28637527; rs5906971; rs28439389; rs35235270; rs3027393; rs28583596; rs6610842; rs6520893; rs35336176; rs5906913; rs12849959; rs36036121; rs5905822; rs5902325; rs5905809; rs11471949; rs6610834; rs3838195; rs3216387; rs33946653; rs6609255; rs35445276; rs7061874; rs17436054; rs1181275; rs12843533; rs2064070; rs3027409; rs3027410; rs3027414; rs3027415; rs3027416; rs3027417; rs4301558; rs4570308; rs5905613; rs6609257; rs6609258; rs7052785; rs727884

# Metabolic_Enzyme_9_General_References:
3418353; 3387449; 1432104; 8584674; 7519662; 3178846; 2764901; 11812236

# Metabolic_Enzyme_9_References:
15351283

# Metabolic_Enzyme_10_ID:
5393

# Metabolic_Enzyme_10_Name:
Amine oxidase [flavin-containing] B

# Metabolic_Enzyme_10_Synonyms:
Monoamine oxidase type B; MAO-B

# Metabolic_Enzyme_10_Gene_Name:
MAOB

# Metabolic_Enzyme_10_Protein_Sequence:
>Amine oxidase flavincontaining 
BMSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGS
YVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFW
RTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHE
VSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYID
QTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIV
YYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEE
RLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVD
RIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITT
TFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV

# Metabolic_Enzyme_10_Number_of_Residues:
520

# Metabolic_Enzyme_10_Molecular_Weight:
58764

# Metabolic_Enzyme_10_Theoretical_pI:
7.55

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine

# Metabolic_Enzyme_10_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_10_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF01593:Amino_oxidase

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
490-516

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 1.4.3.4

# Metabolic_Enzyme_10_GenBank_ID_Protein:
398415

# Metabolic_Enzyme_10_SwissProt_ID:
AOFB_HUMAN (P27338)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
MAOB

# Metabolic_Enzyme_10_Geneatlas_id:
MAOB

# Metabolic_Enzyme_10_hgnc_id:
HGNC:6834

# Metabolic_Enzyme_10_PDB_ID:
2BK3

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type IV membrane protein; cytoplasmic side

# Metabolic_Enzyme_10_Gene_Sequence:
>1560 bp
ATGAGCAACAAATGCGACGTGGTCGTGGTGGGGGGCGGCATCTCAGGTATGGCAGCAGCC
AAACTTCTGCATGACTCTGGACTGAATGTGGTTGTTCTGGAAGCCCGGGACCGTGTGGGA
GGCAGGACTTACACTCTTAGGAACCAAAAGGTTAAATATGTGGACCTTGGAGGATCCTAT
GTTGGACCAACCCAGAATCGTATCTTGAGATTAGCCAAGGAGCTAGGATTGGAGACCTAC
AAAGTGAATGAGGTTGAGCGTCTGATCCACCATGTAAAGGGCAAATCATACCCCTTCAGG
GGGCCATTCCCACCTGTATGGAATCCAATTACCTACTTAGATCATAACAACTTTTGGAGG
ACAATGGATGACATGGGGCGAGAGATTCCGAGTGATGCCCCATGGAAGGCTCCCCTTGCA
GAAGAGTGGGACAACATGACAATGAAGGAGCTACTGGACAAGCTCTGCTGGACTGAATCT
GCAAAGCAGCTTGCCACTCTCTTTGTGAACCTGTGTGTCACTGCAGAGACCCATGAGGTC
TCTGCTCTCTGGTTCCTGTGGTATGTGAAGCAGTGTGGAGGCACAACAAGAATCATCTCG
ACAACAAATGGAGGACAGGAGAGGAAATTTGTGGGCGGATCTGGTCAAGTGAGTGAGCGG
ATAATGGACCTCCTTGGAGACCGAGTGAAGCTGGAGAGGCCTGTGATCTACATTGACCAG
ACAAGAGAAAATGTCCTTGTGGAGACCCTAAACCATGAGATGTATGAGGCTAAATATGTG
ATTAGTGCTATTCCTCCTACTCTGGGCATGAAGATTCACTTCAATCCCCCTCTGCCAATG
ATGAGAAACCAGATGATCACTCGTGTGCCTTTGGGTTCAGTCATCAAGTGTATAGTTTAT
TATAAAGAGCCTTTCTGGAGGAAAAAGGATTACTGTGGAACCATGATTATTGATGGAGAA
GAAGCTCCAGTTGCCTACACGTTGGATGATACCAAACCTGAAGGCAACTATGCTGCCATA
ATGGGATTTATCCTGGCCCACAAAGCCAGAAAACTGGCACGTCTTACCAAAGAGGAAAGG
TTGAAGAAACTTTGTGAACTCTATGCCAAGGTTCTGGGTTCCCTAGAAGCTCTGGAGCCA
GTGCATTATGAAGAAAAGAACTGGTGTGAGGAGCAGTACTCTGGGGGCTGCTACACAACT
TATTTCCCCCCTGGGATCCTGACTCAATATGGAAGGGTTCTACGCCAGCCAGTGGACAGG
ATTTACTTTGCAGGCACCGAGACTGCCACACACTGGAGCGGCTACATGGAGGGGGCTGTA
GAGGCCGGGGAGAGAGCAGCCCGAGAGATCCTGCATGCCATGGGGAAGATTCCAGAGGAT
GAAATCTGGCAGTCAGAACCAGAGTCTGTGGATGTCCCTGCACAGCCCATCACCACCACC
TTTTTGGAGAGACATTTGCCCTCCGTGCCAGGCCTGCTCAGGCTGATTGGATTGACCACC
ATCTTTTCAGCAACGGCTCTTGGCTTCCTGGCCCACAAAAGGGGGCTACTTGTGAGAGTC


# Metabolic_Enzyme_10_GenBank_ID_Gene:
S62734

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_10_Locus:
Xp11.23

# Metabolic_Enzyme_10_SNPs:
rs7879356; rs6324; rs12010260; rs2072745; rs17462; rs3027440; rs7066677; rs3027439; rs1799836; rs3027453; rs2311013; rs3027441; rs5905512; rs3027459; rs2239450; rs2239441; rs7890174; rs5952297; rs3027444; rs5952330; rs7883073; rs5952671; rs6520902; rs2239449; rs6651806; rs3027454; rs7057075; rs12394221; rs2238969; rs12008119; rs7888450; rs12388038; rs2283727; rs12013965; rs17310637; rs12008438; rs5952294; rs5952340; rs12008548; rs12014398; rs1014876; rs3027449; rs2283730; rs2283729; rs5952813; rs6520901; rs5952352; rs2205655; rs10521432; rs6610856; rs12006628; rs3027450; rs6610853; rs2283731; rs3027456; rs2283728; rs9887326; rs5952325; rs3027442; rs7879586; rs12389168; rs3817729; rs12851487; rs5952686; rs3736672; rs2056913; rs1569424; rs7053203; rs2092042; rs7876594; rs12010996; rs3027457; rs9887047; rs3027451; rs17146716; rs7061798; rs3027464; rs6609259; rs3027446; rs736944; rs2239442; rs6609260; rs7067187; rs3027466; rs12558324; rs7888462; rs3027452; rs2092040; rs4824562; rs17146721; rs7884044; rs3027461; rs12389234; rs12007768; rs17244906; rs5952795; rs17146719; rs5905449; rs5952799; rs12394863; rs3027458; rs3027443; rs9698576; rs2092041; rs7892217; rs7061088; rs12689868; rs7067027; rs3027448; rs12558614; rs7057957; rs1040398; rs1040400; rs3027435; rs1181252; rs1040399; rs3027434; rs17852046; rs12850496; rs12845773; rs17856663; rs12845783; rs5952696; rs3191382; rs1181251; rs35285191; rs1051000; rs1803940; rs3027438; rs1051003; rs1050990; rs4339787; rs28530533; rs3027468; rs5952754; rs5952690; rs12558961; rs12852985; rs34468176; rs2311012; rs5905428; rs34165496; rs34825602; rs7892394; rs5952812; rs11091124; rs5906017; rs28522648; rs5952677; rs11282093; rs5906045; rs3838196; rs3027455; rs28667959; rs3027463; rs35676271; rs12841775; rs35574902; rs3027447; rs28657720; rs6610848; rs28531879; rs4824563; rs6610854; rs7060566; rs12396954; rs3027469; rs35687186; rs5952736; rs35375952; rs7057164; rs34716997; rs7062993; rs7063171; rs11412800; rs6651629; rs12845848; rs12853563; rs12012179; rs28368734; rs12115950; rs35968321; rs3027460; rs12394356; rs35439218; rs36085366; rs34265248; rs35762562; rs2239451; rs34292051; rs3027445; rs11320541; rs10481834; rs12845568; rs4592179; rs3216388; rs34945383; rs34220802; rs6610855; rs34261731; rs28485908; rs7888867; rs11431011; rs4071606; rs12390352; rs10567219; rs35520175; rs28527225; rs36068670; rs5952687; rs7888857; rs5952777; rs34822523; rs12010683; rs7883563; rs5952814; rs36209687; rs5952751; rs2238970; rs5952744; rs35797631; rs12389578; rs7474005; rs3027465; rs5952768; rs5906031; rs28636832; rs34252524; rs7058426; rs12391346; rs12689072; rs35943983; rs12395246; rs11414517; rs3027467; rs12013925; rs3736671; rs28421767; rs7058949; rs35634965; rs28754429; rs1894610; rs36102775; rs9887081; rs5952817; rs12855578; rs10658111; rs7062575; rs4620438; rs28568938; rs35291347; rs11797733; rs35054600; rs5952335; rs3027462; rs5952712; rs34752122; rs3054011; rs3027437; rs28577261; rs3027433; rs3761584; rs3027436; rs3027432; rs12558036; rs3027418; rs3027419; rs3027420; rs3027421; rs3027423; rs3027424; rs3027425; rs3027426; rs3027427; rs3027428; rs3027429; rs3027430; rs3027431; rs4351544; rs7884135; rs7890899

# Metabolic_Enzyme_10_General_References:
2023912; 3387449; 8515265; 1432104; 11049757; 11753429

# Metabolic_Enzyme_10_References:
15143488

# Macromolecular_Interacting_Partner_1_ID:
7197

# Macromolecular_Interacting_Partner_1_Name:
Corticotropin-lipotropin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Pro-opiomelanocortin; POMC[Contains: NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin]

# Macromolecular_Interacting_Partner_1_Gene_Name:
POMC

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Corticotropinlipotropin precursor
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
267

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
29424

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Beta-endorphin and Met-enkephalin are endogenous opiates

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00976:ACTH_domain;
PF08384:NPP;
PF08035:Op_neuropeptide

# Macromolecular_Interacting_Partner_1_Signals:
1-26

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
190188

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
COLI_HUMAN (P01189)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
POMC

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
POMC

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9201

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>789 bp
TGCAGCCGCTCGGGGGCCCTGTTGCTGGCCTTGCTGCTTCAGGCCTCCATGGAAGTGCGT
GGCTGGTGCCTGGAGAGCAGCCAGTGTCAGGACCTCACCACGGAAAGCAACCTGCTGGAG
TGCATCCGGGCCTGCAAGCCCGACCTCTCGGCCGAGACTCCCATGTTCCCGGGAAATGGC
GACGAGCAGCCTCTGACCGAGAACCCCCGGAAGTACGTCATGGGCCACTTCCGCTGGGAC
CGATTCGGCCGCCGCAACAGCAGCAGCAGCGGCAGCAGCGGCGCAGGGCAGAAGCGCGAG
GACGTCTCAGCGGGCGAAGACTGCGGCCCGCTGCCTGAGGGCGGCCCCGAGCCCCGCAGC
GATGGTGCCAAGCCGGGCCCGCGCGAGGGCAAGCGCTCCTACTCCATGGAGCACTTCCGC
TGGGGCAAGCCGGTGGGCAAGAAGCGGCGCCCAGTGAAGGTGTACCCTAACGGCGCCGAG
GACGAGTCGGCCGAGGCCTTCCCCCTGGAGTTCAAGAGGGAGCTGACTGGCCAGCGACTC
CGGGAGGGAGATGGCCCCGACGGCCCTGCCGATGACGGCGCAGGGGCCCAGGCCGACCTG
GAGCACAGCCTGCTGGTGGCGGCCGAGAAGAAGGACGAGGGCCCCTACAGGATGGAGCAC
TTCCGCTGGGGCAGCCCGCCCAAGGACAAGCGCTACGGCGGTTTCATGACCTCCGAGAAG
AGCCAGACGCCCCTGGTGACGCTGTTCAAAAACGCCATCATCAAGAACGCCTACAAGAAG
GGCGAGTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M38297

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_1_Locus:
2p23.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs28932472; rs8192606; rs28932471; rs35254395; rs8192605; rs28930368; rs2071345; rs34650613; rs1042571; rs11679531; rs6713532; rs7565877; rs6713396; rs12473543; rs6756695; rs6545975; rs6756566; rs28932474; rs28932476; rs28932475; rs28932473; rs10654394; rs28932470; rs3039380; rs35411223; rs35023083; rs33950052; rs7591899; rs15461; rs2071344; rs13388660; rs9973478; rs11353932; rs13404336; rs7565427; rs34619618; rs8192607; rs35639116; rs34526166; rs10188864; rs10195561; rs11892647; rs12472851; rs13418937; rs17046887; rs17046891; rs1866146; rs2071343; rs2118404; rs2164808; rs3769671; rs3795955; rs3820935; rs6545976; rs6719226; rs6734859; rs7589318; rs7605927; rs934778

# Macromolecular_Interacting_Partner_1_General_References:
6274691; 6299668; 6314261; 3606677; 6254047; 6945581; 6267033; 6272808; 4352834; 4334191; 4338630; 4347148; 1264228; 195688; 2424570; 2839146; 7828531; 9768693; 10193875; 11244459

# Macromolecular_Interacting_Partner_1_References:
10442254; 9530229

# Macromolecular_Interacting_Partner_2_ID:
7547

# Macromolecular_Interacting_Partner_2_Name:
Somatotropin precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Growth hormone; GH; GH-N; Pituitary growth hormone; Growth hormone 1

# Macromolecular_Interacting_Partner_2_Gene_Name:
GH1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Somatotropin precursor
MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEA
YIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLR
SVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDD
ALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
217

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
24848

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.09

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_2_Signals:
1-26

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
31905

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
SOMA_HUMAN (P01241)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
GH1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
GH1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:4261

# Macromolecular_Interacting_Partner_2_PDB_ID:
1HWG

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>654 bp
ATGGCTACAGGCTCCCGGACGTCCCTGCTCCTGGCTTTTGGCCTGCTCTGCCTGCCCTGG
CTTCAAGAGGGCAGTGCCTTCCCAACCATTCCCTTATCCAGGCCTTTTGACAACGCTATG
CTCCGCGCCCATCGTCTGCACCAGCTGGCCTTTGACACCTACCAGGAGTTTGAAGAAGCC
TATATCCCAAAGGAACAGAAGTATTCATTCCTGCAGAACCCCCAGACCTCCCTCTGTTTC
TCAGAGTCTATTCCGACACCCTCCAACAGGGAGGAAACACAACAGAAATCCAACCTAGAG
CTGCTCCGCATCTCCCTGCTGCTCATCCAGTCGTGGCTGGAGCCCGTGCAGTTCCTCAGG
AGTGTCTTCGCCAACAGCCTGGTGTACGGCGCCTCTGACAGCAACGTCTATGACCTCCTA
AAGGACCTAGAGGAAGGCATCCAAACGCTGATGGGGAGGCTGGAAGATGGCAGCCCCCGG
ACTGGGCAGATCTTCAAGCAGACCTACAGCAAGTTCGACACAAACTCACACAACGATGAC
GCACTACTCAAGAACTACGGGCTGCTCTACTGCTTCAGGAAGGACATGGACAAGGTCGAG
ACATTCCTGCGCATCGTGCAGTGCCGCTCTGTGGAGGGCAGCTGTGGCTTCTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00519

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_2_Locus:
17q24.2

# Macromolecular_Interacting_Partner_2_SNPs:
rs2001345; rs5388; rs6175; rs6173; rs6172; rs2665802; rs3744287; rs2001344; rs3020619; rs2005172; rs695; rs2854224; rs2854184; rs11568828; rs2011732; rs1974435; rs1811081; rs6171; rs2005171; rs2005170; rs7219235; rs2727338; rs6174; rs4080075; rs4080076; rs41295255; rs41295253; rs4080078; rs41295041; rs41295043; rs9282699; rs41295039; rs41295033; rs5821407; rs5821408; rs41295029; rs3833113; rs41295249; rs41295245; rs5821409; rs9282698; rs41295251; rs41295035; rs41295037; rs41295031; rs41295247; rs4341800; rs41299067; rs6146116; rs28485730; rs41295013; rs11568827; rs41295009; rs41295017; rs3760240; rs12945660; rs41295015; rs41299065; rs11079515; rs11657170; rs12946669; rs2070680; rs2532114; rs2532115; rs2665846; rs3180510; rs7209608

# Macromolecular_Interacting_Partner_2_General_References:
386281; 377496; 6269091; 7169009; 2744760; 10931946; 3912261; 5810834; 5144027; 4675454; 5279046; 5279528; 7462247; 7356479; 7028740; 10393484; 3447173; 1549776; 7984244; 8943276; 8552145; 9276733; 10391209; 11502836; 12655557

# Macromolecular_Interacting_Partner_2_References:
10072397; 12620340

# Macromolecular_Interacting_Partner_3_ID:
7556

# Macromolecular_Interacting_Partner_3_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_3_Signals:
1-18

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_3_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_3_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_3_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_3_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_3_References:
10916286; 9385460

# Macromolecular_Interacting_Partner_4_ID:
7649

# Macromolecular_Interacting_Partner_4_Name:
Sodium-dependent serotonin transporter

# Macromolecular_Interacting_Partner_4_Synonyms:
5HT transporter; 5HTT

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC6A4

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Sodiumdependent serotonin transporter
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
630

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
70325

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.17

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  transporter activity
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF03491:5HT_transporter;
PF00209:SNF

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
88-108
116-135
160-180
253-271
280-297
333-350
362-383
417-436
464-482
498-518
539-558
577-595

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
36433

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
SC6A4_HUMAN (P31645)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC6A4

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC6A4

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11050

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1893 bp
ATGGAGACGACGCCCTTGAATTCTCAGAAGCAGCTATCAGCGTGTGAAGATGGAGAAGAT
TGTCAGGAAAACGGAGTTCTACAGAAGGTTGTTCCCACCCCAGGGGACAAAGTGGAGTCC
GGGCAAATATCCAATGGGTACTCAGCAGTTCCAAGTCCTGGTGCGGGAGATGACACACGG
CACTCTATCCCAGCGACCACCACCACCCTAGTGGCTGAGCTTCATCAAGGGGAACGGGAG
ACCTGGGGCAAGAAGGTGGATTTCCTTCTCTCAGTGATTGGCTATGCTGTGGACCTGGGC
AATGTCTGGCGCTTCCCCTACATATGTTACCAGAATGGAGGGGGGGCATTCCTCCTCCCC
TACACCATCATGGCCATTTTTGGGGGAATCCCGCTCTTTTACATGGAGCTCGCACTGGGA
CAGTACCACCGAAATGGATGCATTTCAATATGGAGGAAAATCTGCCCGATTTTCAAAGGG
ATTGGTTATGCCATCTGCATCATTGCCTTTTACATTGCTTCCTACTACAACACCATCATG
GCCTGGGCGCTATACTACCTCATCTCCTCCTTCACGGACCAGCTGCCCTGGACCAGCTGC
AAGAACTCCTGGAACACTGGCAACTGCACCAATTACTTCTCCGAGGACAACATCACCTGG
ACCCTCCATTCCACGTCCCCTGCTGAAGAATTTTACACGCGCCACGTCCTGCAGATCCAC
CGGTCTAAGGGGCTCCAGGACCTGGGGGGCATCAGCTGGCAGCTGGCCCTCTGCATCATG
CTGATCTTCACTGTTATCTACTTCAGCATCTGGAAAGGCGTCAAGACCTCTGGCAAGGTG
GTGTGGGTGACAGCCACCTTCCCTTATATCATCCTTTCTGTCCTGCTGGTGAGGGGTGCC
ACCCTCCCTGGAGCCTGGAGGGGTGTTCTCTTCTACTTGAAACCCAATTGGCAGAAACTC
CTGGAGACAGGGGTGTGGATAGATGCAGCCGCTCAGATCTTCTTCTCTCTTGGTCCGGGC
TTTGGGGTCCTGCTGGCTTTTGCTAGCTACAACAAGTTCAACAACAACTGCTACCAAGAT
GCCCTGGTGACCAGCGTGGTGAACTGCATGACGAGCTTCGTTTCGGGATTTGTCATCTTC
ACAGTGCTCGGTTACATGGCTGAGATGAGGAATGAAGATGTGTCTGAGGTGGCCAAAGAC
GCAGGTCCCAGCCTCCTCTTCATCACGTATGCAGAAGCGATAGCCAACATGCCAGCGTCC
ACTTTCTTTGCCATCATCTTCTTTCTGATGTTAATCACGCTGGGCTTGGACAGCACGTTT
GCAGGCTTGGAGGGGGTGATCACGGCTGTGCTGGATGAGTTCCCACACGTCTGGGCCAAG
CGCCGGGAGCGGTTCGTGCTCGCCGTGGTCATCACCTGCTTCTTTGGATCCCTGGTCACC
CTGACTTTTGGAGGGGCCTACGTGGTGAAGCTGCTGGAGGAGTATGCCACGGGGCCCGCA
GTGCTCACTGTCGCGCTGATCGAAGCAGTCGCTGTGTCTTGGTTCTATGGCATCACTCAG
TTCTGCAGGGACGTGAAGGAAATGCTCGGCTTCAGCCCGGGGTGGTTCTGGAGGATCTGC
TGGGTGGCCATCAGCCCTCTGTTTCTCCTGTTCATCATTTGCAGTTTTCTGATGAGCCCG
CCACAACTACGACTTTTCCAATATAATTATCCTTACTGGAGTATCATCTTGGGTTACTGC
ATAGGAACCTCATCTTTCATTTGCATCCCCACATATATAGCTTATCGGTTGATCATCACT
CCAGGGACATTTAAAGAGCGTATTATTAAAAGTATTACCCCGGAGACACCAACAGAAATT
CCTTGTGGGGACATCCGCTTGAATGCTGTGTAA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
X70697

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_4_Locus:
17q11.1-q12

# Macromolecular_Interacting_Partner_4_SNPs:
rs6352; rs28914834; rs6355; rs2228673; rs28914833; rs28914832; rs33919215; rs28914828; rs6353; rs6354; rs1042173; rs2020936; rs25528; rs2020938; rs2066713; rs2020933; rs2020939; rs8071667; rs16965623; rs2020934; rs8080561; rs2020941; rs7212502; rs12150214; rs9896947; rs8072742; rs28914827; rs28914831; rs4251417; rs16965628; rs2020935; rs11872020; rs9903602; rs2020937; rs13306796; rs9903062; rs140701; rs2020942; rs717742; rs4325622; rs1872924; rs11080121; rs4583306; rs12449783; rs7216572; rs11653903; rs9303628; rs3794809; rs12450956; rs140700; rs3794808; rs4340379; rs1972305; rs8076005; rs13306794; rs28914830; rs11657536; rs16965581; rs11652121; rs9913038; rs7217065; rs9895500; rs28914829; rs34956669; rs11080122; rs34083002; rs2054848; rs34149483; rs2054847; rs2020932; rs7224199; rs8066731; rs25533; rs8066602; rs3813034; rs25531; rs28914823; rs956304; rs8081028; rs28914822; rs28914824; rs41274284; rs41274280; rs9911216; rs8073965; rs34102420; rs2020940; rs35517167; rs35444174; rs28914826; rs3783594; rs28409885; rs11417957; rs3783593; rs7342958; rs9892034; rs34751299; rs28914825; rs35393203; rs4514736; rs35697904; rs34871173; rs35206195; rs9910814; rs34035581; rs34500314; rs11472475; rs35153926; rs10438799; rs41274288; rs34332000; rs11300640; rs13306793; rs34121055; rs5819884; rs35370520; rs34764815; rs35721756; rs35842343; rs35788610; rs28441519; rs35246799; rs34828373; rs35600349; rs8071583; rs34459452; rs10438800; rs10688568; rs13306792; rs35886704; rs34954201; rs4636964; rs34210514; rs35659820; rs5819887; rs34185064; rs41274286; rs140702; rs34876533; rs10554393; rs34388196; rs9912813; rs7218956; rs5819885; rs745706; rs34405962; rs140698; rs41274282; rs5819882; rs35958391; rs3034289; rs35436651; rs9916159; rs5819886; rs13306795; rs34586405; rs10604158; rs9652882; rs34019821; rs5819883; rs34129293; rs35467658; rs35623510; rs10650671; rs34454216; rs140699; rs3829614; rs9906039; rs9915959; rs34921362; rs10646168; rs12150096; rs34070525; rs3064100; rs7210477; rs2321495; rs4795542; rs5819888; rs35519003; rs25532; rs35122351; rs28407157; rs35863620; rs34845320; rs25530; rs35514331; rs34542731; rs35263750; rs12150465; rs12452540; rs12945042; rs16965639; rs1906451; rs2020930; rs4392119; rs7214991; rs9894397; rs9896129

# Macromolecular_Interacting_Partner_4_General_References:
8452685; 7681602; 7684072; 10391209; 12869766

# Macromolecular_Interacting_Partner_4_References:
15589347; 15804496

# Macromolecular_Interacting_Partner_5_ID:
5894

# Macromolecular_Interacting_Partner_5_Name:
Long-chain-fatty-acid--CoA ligase 6

# Macromolecular_Interacting_Partner_5_Synonyms:
Long-chain acyl-CoA synthetase 6; LACS 6

# Macromolecular_Interacting_Partner_5_Gene_Name:
ACSL6

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>LongchainfattyacidCoA ligase 6
MQTQEILRILRLPELGDLGQFFRSLSATTLVSMGALAAILAYWFTHRPKALQPPCNLLMQ
SEEVEDSGGARRSVIGSGPQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPKQPYQW
LSYQEVADRAEFLGSGLLQHNCKACTDQFIGVFAQNRPEWIIVELACYTYSMVVVPLYDT
LGPGAIRYIINTADISTVIVDKPQKAVLLLEHVERKETPGLKLIILMDPFEEALKERGQK
CGVVIKSMQAVEDCGQENHQAPVPPQPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGF
LKVTEKVIFPRQDDVLISFLPLAHMFERVIQSVVYCHGGRVGFFQGDIRLLSDDMKALCP
TIFPVVPRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKI
QASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHV
GAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGD
IGKWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGI
VVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQVKAIHIHS
DMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
697

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
77753

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
7.46

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Lipid transport and metabolism 

# Macromolecular_Interacting_Partner_5_Specific_Function:
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid

# Macromolecular_Interacting_Partner_5_Pathway:
map00071  Fatty acid metabolism

# Macromolecular_Interacting_Partner_5_Reaction:
ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00501:AMP-binding

# Macromolecular_Interacting_Partner_5_Signals:
1-37

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
EC 6.2.1.3

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
5702202

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
ACSL6_HUMAN (Q9UKU0)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
ACSL6

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
ACSL6

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:16496

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type III membrane protein. Peroxisome; peroxisomal membrane; single-pass type III membrane protein (By similarity). Microsome; microsomal membrane; single-pass type III membrane protein (By similarity)

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>2094 bp
ATGCAGACACAGGAGATCCTGAGGATACTGCGACTGCCTGAGCTAGGTGACTTGGAACAG
TTTTTCCGCAGCCTCTCGGCCACCACCCTCGTGAGTATGGGTGCCCTGGCTGCCATCCTT
GCCTACTGGTTCACTCAGCGGCCAAAGGCCTTGCAGCCGCCATGCAACCTCCTGATGCAG
TCAGAAGAAGTAGAGGACAGTGGCGGGGCACGGCGATCTGTGATTGGGTCTGGCCCTCAG
CTACTTACCCACTACTATGATGATGCCCGGACCATGTACCAGGTGTTCCGCCGTGGGCTT
AGCATCTCAGGGAATGGGCCCTGTCTTGGTTTCAGGAAGCCTAAGCAGCCTTACCAGTGG
CTGTCCTACCAGGAGGTGGCCGACAGGGCTGAATTTCTGGGGTCCGGACTTCTCCAGCAC
AATTGTAAAGCATGCACTGATCAGTTTATTGGTGTTTTTGCACAAAATCGGCCAGAGTGG
ATCATTGTGGAGCTGGCCTGCTACACATATTCCATGGTGGTGGTCCCGCTCTATGACACC
CTGGGCCCTGGGGCTATCCGCTACATCATCAATACAGCGGACATCAGCACCGTGATTGTG
GACAAACCTCAGAAGGCTGTGCTTCTGCTAGAGCATGTGGAGAGGAAGGAGACTCCAGGC
CTCAAGCTGATCATCCTCATGGACCCATTCGAAGAAGCCCTGAAAGAGAGAGGGCAGAAG
TGCGGGGTGGTCATTAAGTCCATGCAGGCCGTGGAGGACTGTGGCCAAGAGAATCACCAG
GCTCCTGTGCCCCCGCAGCCTGATGACCTCTCCATTGTGTGTTTCACAAGCGGCACGACA
GGGAACCCAAAAGGTGCGATGCTCACCCATGGGAACGTGGTGGCTGATTTCTCAGGCTTT
CTGAAAGTGACAGAGAGTCAGTGGGCTCCCACTTGTGCGGATGTGCACATTTCCTATTTG
CCTTTAGCACACATGTTTGAGCGAATGGTGCAGTCTGTCGTCTATTGCCACGGAGGGCGT
GTTGGCTTCTTCCAGGGAGATATCCGCCTTCTCTCAGATGACATGAAGGCTCTATGCCCC
ACCATCTTCCCTGTGGTCCCACGACTGCTGAACCGGATGTACGACAAGATCTTCAGCCAG
GCAAACACACCATTAAAGCGCTGGCTCCTGGAGTTTGCAGCAAAGCGTAAGCAAGCCGAG
GTCCGGAGTGGAATCATCAGGAATGATAGTATCTGGGATGAACTCTTCTTTAATAAGATT
CAGGCCAGTCTTGGTGGGTGTGTGCGGATGATTGTTACTGGAGCAGCCCCAGCATCACCA
ACAGTTCTGGGATTTCTCCGGGCAGCTCTAGGGTGCCAGGTTTATGAAGGTTATGGCCAA
ACTGAGTGCACAGCTGGATGTACCTTCACCACTCCTGGCGACTGGACCTCAGGGCACGTA
GGGGCGCCACTTCCCTGCAATCATATCAAGCTCGTTGATGTTGAGGAACTGAACTACTGG
GCCTGCAAAGGAGAGGGAGAGATATGTGTGAGAGGACCAAATGTGTTCAAAGGCTACTTG
AAAGATCCAGACAGGACGAAGGAGGCCCTGGACAGCGATGGCTGGCTTCACACTGGAGAC
ATCGGAAAATGGCTGCCGGCAGGAACTCTTAAAATTATTGATCGGAAAAAGCATATATTT
AAACTTGCTCAGGGAGAATATGTTGCACCCGAGAAGATTGAGAACATCTACATCCGGAGC
CAACCTGTGGCGCAAATCTATGTCCATGGGGACAGCTTAAAGGCCTTTTTGGTAGGCATT
GTTGTGCCTGACCCTGAAGTTATGCCCTCCTGGGCCCAGAAGAGAGGAATTGAAGGAACA
TATGCAGATCTCTGCACAAATAAGGATCTGAAGAAAGCCATTTTGGAAGATATGGTGAGG
TTAGGAAAAGAAAGTGGACTCCATTCTTTTGAGCAGGTTAAAGCCATTCACATCCATTCT
GACATGTTCTCAGTTCAAAATGGCTTGCTGACCCCAACACTAAAAGCTAAGAGACCTGAG
CTGAGAGAGTACTTCAAAAAACAAATAGAAGAGCTTTACTCAATCCCCATGTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AF129166

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Locus:
Not Available

# Macromolecular_Interacting_Partner_5_SNPs:
Not Available

# Macromolecular_Interacting_Partner_5_General_References:
10548543; 10502316; 10048485

# Macromolecular_Interacting_Partner_5_References:
12552148; 15466221; 9869404

# Macromolecular_Interacting_Partner_6_ID:
8284

# Macromolecular_Interacting_Partner_6_Name:
POU domain, class 6, transcription factor 1

# Macromolecular_Interacting_Partner_6_Synonyms:
mPOU homeobox protein; Brain-specific homeobox/POU domain protein 5; Brain-5; Brn-5 protein

# Macromolecular_Interacting_Partner_6_Gene_Name:
POU6F1

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>POU domain, class 6, transcription factor 1
MPGISSQILTNAQGQVIGTLPWVVNSASVAAPAPAQSLQVQAVTPQLLLNAQGQVIATLA
SSPLPPPVAVRKPSTPESPAKSEVQPIQPTPTVPQPAVVIASPAPAAKPSASAPIPITCS
ETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAY
SQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELRNQEGQQNLMEFVGGEPSKKRKRRTS
FTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKLNVFQI
P

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
301

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
32646

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
9.71

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  transcription factor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3')

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00046:Homeobox;
PF00157:Pou

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
437807

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
PO6F1_HUMAN (Q14863)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
POU6F1

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
POU6F1

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:9224

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>906 bp
ATGCCAGGGATCAGCAGTCAGATCCTCACCAATGCTCAGGGACAGGTTATTGGAACCCTT
CCATGGGTAGTGAACTCAGCTAGTGTGGCGGCCCCAGCACCAGCCCAAAGCCTGCAGGTC
CAGGCCGTGACCCCCCAGCTGTTGTTGAACGCCCAGGGCCAGGTGATTGCGACCCTGGCT
AGCAGCCCCCTGCCTCCACCTGTGGCTGTCCGGAAGCCAAGCACACCTGAGTCCCCTGCT
AAGAGTGAGGTGCAGCCCATCCAGCCCACACCAACCGTGCCCCAGCCTGCTGTGGTCATT
GCCAGCCCAGCTCCAGCCGCCAAGCCATCTGCCTCTGCTCCTATCCCAATTACCTGCTCA
GAGACCCCCACCGTCAGCCAGTTGGTGTCCAAGCCACATACTCCAAGTCTGGATGAGGAT
GGGATCAACTTAGAAGAGATCCGGGAGTTTGCCAAGAACTTTAAGATCCGGCGGCTCTCG
CTGGGCCTTACACAGACCCAGGTGGGTCAGGCTCTGACTGCAACGGAAGGTCCAGCCTAC
AGCCAGTCAGCCATCTGCCGGTTCGAGAAGCTAGACATCACACCCAAGAGTGCCCAGAAG
CTAAAGCCGGTGCTGGAAAAGTGGCTAAACGAAGCTGAACTGCGGAACCAGGAAGGCCAG
CAGAACCTGATGGAGTTTGTGGGAGGCGAGCCCTCCAAGAAACGCAAGCGCCGCACCTCC
TTCACCCCCCAGGCCATAGAGGCTCTCAATGCCTATTTTGAGAAGAACCCACTGCCCACA
GGCCAGGAGATCACTGAAATTGCTAAGGAGCTCAACTACGACCGTGAGGTAGTGCGGGTC
TGGTTCTGCAATCGGCGCCAGACGCTCAAGAACACCAGCAAGCTGAACGTCTTTCAGATC
CCTTAG

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
Z21966

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_6_Locus:
12q13.13

# Macromolecular_Interacting_Partner_6_SNPs:
rs2228250; rs3490; rs6580806; rs10735832; rs10783420; rs6580809; rs6580808; rs7399018; rs11169761; rs11169762; rs7953167; rs6580810; rs7398010; rs10431487; rs7976292; rs12321105; rs12579347; rs2067902; rs7978956; rs6580807; rs4077093; rs7953955; rs7975737; rs10876154; rs7398898; rs7487157; rs10747607; rs10783419; rs10735831; rs10876152; rs12423352; rs10876153; rs11608364; rs12422846; rs12818718; rs11169757; rs10747606; rs11169756; rs12427003; rs11169758; rs7139213; rs11738; rs10747605; rs11169754; rs6580812; rs7398442; rs6580811; rs10876151; rs7398443; rs11169753; rs7136904; rs7953179; rs34561796; rs11338427; rs10635177; rs35859212; rs34579947; rs7487084; rs4076884; rs11614575; rs35232120; rs7398548; rs34020048; rs10627145; rs11169765; rs11316062; rs11169766; rs11430419; rs36209221; rs11330373; rs11169763; rs35125408; rs35590618; rs34746884; rs12822272; rs34500149; rs1126905; rs11435715; rs7953168; rs34296849; rs12311780; rs12370642; rs33928625; rs12307209; rs1126902; rs12300868; rs11613752; rs34124371; rs7298195; rs35144503; rs34741889; rs7970927; rs1126904; rs11427576; rs11415220; rs34001388; rs7397586; rs34564724; rs11169759; rs11276817; rs7484430; rs9668643; rs12819854; rs7297398; rs36104838; rs34825516; rs6580805; rs33997850; rs11361026; rs11169755; rs34325113; rs10718259; rs35513339; rs34748839; rs35515176; rs11386813; rs10783416; rs10783418; rs11169743; rs11169744; rs11169745; rs11169747; rs11169748; rs11169752; rs1607; rs6580803; rs7134808; rs7399073; rs7963824

# Macromolecular_Interacting_Partner_6_General_References:
7908264

# Macromolecular_Interacting_Partner_6_References:
9771918; 9855498

End of HMDB00197

Beginning of HMDB00201
# Accession_No:
HMDB00201

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-09-11 12:16:25

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
L-Acetylcarnitine

# Description:
An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS. In addition to his metabolic role, acetyl-L-carnitine (ALC) posses unique neuroprotective, neuromodulatory, and neurotrophic properties this may play an important role in counteracting various disease processes.  (PubMed ID 15363640) 

# Synonyms:
(-)-Acetylcarnitine; (R)-Acetylcarnitine; ALCAR; Acetyl-L-(-)-carnitine; Acetyl-L-carnitine; Acetylcarnitine; L-Acetylcarnitine; L-Carnitine acetyl ester; L-O-Acetylcarnitine; Levocarnitine acetyl; Nicetile; O-Acetyl-L-carnitine; O-Acetylcarnitine; (+-)-Acetylcarnitine 

# Chemical_IUPAC_Name:
(3S)-3-acetyloxy-4-trimethylammonio-butanoate

# Chemical_Formula:
C9H17NO4

# Chemical_Structure:
tbl_chemical:::HMDB00201_ZOOM.png:::119283248711650272

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00201_THUMB.png:::119283248549732943

# Taxonomy_Kingdom:
Organic Salt

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
cation; quaternary ammonium salt; carboxylic acid; carboxylic acid ester

# Taxonomy_Biofunction:
Component of Alanine and aspartate metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
203.11575

# Molecular_Weight_Avg:
203.23558

# Smiles_String_isomeric:
CC(=O)OC(CC([O-])=O)C[N+](C)(C)C

# Smiles_String_canonical:
CC(=O)OC(CC([O-])=O)C[N+](C)(C)C

# KEGG_Compound_ID:
C02571

# BioCyc_ID:
(-)o-acetylcarnitine

# PubChem_CID:
18230

# PubChem_SID:
11113462; 10938193; 5567; 8145064

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
1442845

# Wikipedia_ID:
Acetyl-L-carnitine

# METLIN_ID:
5213

# Ref_ID:
1863104; 1479006; 8074302; 3769216; 1944900; 480318; 10491992; 12905800; 2328258; 1820908; 571081; 2792144; 2380667; 8214594; 8534410; 11069438; 15801863; 16179519; 12414265; 12471321

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
3040-38-8

# InChI:
InChI=1/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3

# Synthesis_Reference:
Chemical synthesis of Acetyl-L-carnitine and its enzymatic resolution.     Ding, Tian-bing; Wang, Zhi; Weng, Liang; Yu, Da-hai; Zheng, Liang-yu; Cao, Shu-gui; Gou, Xiao-jun.    Key Laboratory for Molecular Enzymology and Engineering of Educational Ministr

# Melting_Point:
145

# Melting_Point_predicted:
36.9 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
0.355 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.38 [Predicted by ALOGPS]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::L-Acetylcarnitine.pdf:::1132562215641940296

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::L-Acetylcarnitine.mol:::1132723813578864430

# SDF_File_[Text]:
tbl_chemical:::HMDB00201.sdf:::119283248155656554

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00201.pdb:::119283248413129369

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::L-Acetylcarnitine.gif:::1132732121609715960

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00201_peaks.txt:::1156309614555305979

# Predicted_C_NMR_Spectrum:
tbl_chemical:::L-Acetylcarnitine_C.gif:::113273772150983418

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00201_peaks.txt:::1156310803793792018

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00201.png:::1165435196002616902; Medium Energy:tbl_ms:::HMDB00201.png:::1165434630398118922; High Energy:tbl_ms:::HMDB00201.png:::1165434822259880504

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; endoplasmic reticulum; mitochondria; peroxisome

# Tissue_Location:
Brain; Muscle; Nerves; Neurons; Skeletal Muscle; Spermatozoa

# deuterated:
No

# Biofluid_Location:
Amniotic Fluid; Blood; Semen; Urine

# Concentration_[Normal]:
Urine	1.928 +/- 0.2829	umol/mmol_creatinine	Adult:>18_yrs_old	Female	Normal	12905800
Blood	6.2 +/- 0.6	uM	Adult:>18_yrs_old	Male	Normal	12905800
Blood	5.7 +/- 0.7	uM	Adult:>18_yrs_old	Female	Normal	12905800


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Alzheimer's Disease; Cachexia ; Cerebral Ischemia; Dementia

# Pathway_Names:
Alanine and aspartate metabolism

# Pathway_Images:
Aspartate_and_Alanine_metabolism.jpg

# KEGG_Images:
map00252

# Pathway_Graphs:
Aspartate_and_Alanine_metabolism_Graph.jpg

# Pathway_SBMLs:
Aspartate_and_Alanine_metabolism.xml

# Metabolic_Enzyme_1_ID:
5257

# Metabolic_Enzyme_1_Name:
Carnitine O-acetyltransferase

# Metabolic_Enzyme_1_Synonyms:
Carnitine acetylase; CAT; Carnitine acetyltransferase; CrAT

# Metabolic_Enzyme_1_Gene_Name:
CRAT

# Metabolic_Enzyme_1_Protein_Sequence:
>Carnitine Oacetyltransferase
MLAFAARTVVKPLGFLKPFSLMKASSRFKAHQDALPRLPVPPLQQSLDHYLKALQPIVSE
EEWAHTKQLVDEFQASGGVGERLQKGLERRARKTENWLSEWWLKTAYLQYRQPVVIYSSP
GVMLPKQDFVDLQGQLRFAAKLIEGVLDFKVMIDNETLPVEYLGGKPLCMNQYYQILSSC
RVPGPKQDTVSNFSKTKKPPTHITVVHNYQFFELDVYHSDGTPLTADQIFVQLEKIWNSS
LQTNKEPVGILTSNHRNSWAKAYNTLIKDKVNRDSVRSIQKSIFTVCLDATMPRVSEDVY
RSHVAGQMLHGGGSRLNSGNRWFDKTLQFIVAEDGSCGLVYEHAAAEGFPIVTLLDYVIE
YTKKPELVRSPMVPLPMPKKLRFNITPEIKSDIEKAKQNLSIMIQDLDITVMVFHHFGKD
FPKSEKLSPDAFIQMALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSASMDSLTFVK
AMDDSSVTEHQKVELLRKAVQAHRGYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMD
TSYAIAMHFHLSTSQVPAKTDCVMFFGPVVPDGYGVCYNPMEAHINFSLSAYNSCAETNA
ARLAHYLEKALLDMRALLQSHPRAKL

# Metabolic_Enzyme_1_Number_of_Residues:
626

# Metabolic_Enzyme_1_Molecular_Weight:
70927

# Metabolic_Enzyme_1_Theoretical_pI:
8.63

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria

# Metabolic_Enzyme_1_Pathway:
map00252  Alanine and aspartate metabolism

# Metabolic_Enzyme_1_Reaction:
acetyl-CoA + carnitine = CoA + O-acetylcarnitine

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00755:Carn_acyltransf

# Metabolic_Enzyme_1_Signals:
1-16

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.3.1.7

# Metabolic_Enzyme_1_GenBank_ID_Protein:
927415

# Metabolic_Enzyme_1_SwissProt_ID:
CACP_HUMAN (P43155)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
CRAT

# Metabolic_Enzyme_1_Geneatlas_id:
CRAT

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2342

# Metabolic_Enzyme_1_PDB_ID:
1S5O

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Endoplasmic reticulum (Potential). Peroxisome (Potential). Mitochondrion; mitochondrial inner membrane; matrix side (Potential)

# Metabolic_Enzyme_1_Gene_Sequence:
>1876 bp
AGCCTTCGCTGCCAGGACCGTGGTGAAGCCTCTGGGCTTCCTGAAGCCCTTCTCCTTGAT
GAAGGCTTCCAGCCGCTTCAAGGCACACCAGGATGCCCTGCCACGGCTGCCCGTGCCCCC
TCTCCAGCAGTCCCTGGACCACTACCTGAAGGCGCTGCAGCCCATCGTGAGTGAGGAGGA
GTGGGCCCACACCAAGCAGCTGGTGGATGAGTTTCAGGCCTCAGGAGGTGTAGGGGAGCG
CCTGCAGAAGGGGCTGGGGCGTCGGGCCAGGAAGACGGAGAACTGGCTGTCTGAGTGGTG
GCTCAAGACCGCCTACCTCCAGTACCGCCAGCCTGTGGTCATCTACTCGAGCCCAGGCGT
GATGCTACCCAAGCAGGACTTCGTGGACCTGCAGGGTCAGCTCCGATTTGCTGCCAAACT
CATTGAGGGTGTGTTGGATTTCAAGGTCATGATTGACAACGAGACCCTGCCCGTGGAGTA
CCTGGNGGGGAAGCCACTGTGCATGAACCAGTACTATCAGATCTTGTCCTCCTGCCGAGT
GCCGGGCCCCAAGCAGGACACAGTCAGCAACTTCAGCAAGACCAAGAAGCCTCCCACGCA
CATCACCGTGGTACACAACTACCAGTTTTTTGAGCTGGATGTGTACCACAGTGACGGGAC
ACCCCTCACTGCGGATCAGATCTTTGTGCAGCTGGAGAAGATCTGGAACTCATCCCTACA
GACCAACAAGGAGCCTGTGGGCATCCTCACCTCCAACCACCGCAACTCCTGGGCCAAGGC
ATACAACACCCTCATCAAAGACAAGGTGAACCGGGATTCCGTGCGCTCCATCCAGAAGAG
CATCTTCACCGTGTGCCTAGATGCAACCATGCCCAGGGTCTCAGAAGACGTGTACCGCAG
CCACGTGGCAGGCCAGATGCTGCATGGGGGCGGCAGCAGGCTCAACAGCGGCAACCGCTG
GTTTGACAAGACGCTGCAGTTCATCGTGGCAGAAGATGGCTCCTGTGGGCTTGTGTACGA
GCATGCTGCAGCNGAGGGTTTCCCTATTGTCACCCTTCTGGACTATGTCATCGAGTACAC
GAAGAAACCCGAGCTTGTGCNGTCTCCCATGGTGCCCCTGCCCATGCCCAAGAAGCTGCG
GTTCAACATCACCCCCGAGATCAAGAGCGACATCGAGAAGGCCAAGCAGAACCTCAGCAT
CATGATCCANNACCTGGATATCACCGTGATGGTGTTCCACCATTTTGGAAAAGACTTCCC
CAAGTCGGAGAAGCTAAGCCCAGATGCCTTCATCCAGATGGCTTTGCAGCTGGCCTACTA
CAGGATCTACGGACAGGCATGTGCCACCTATGAAAGTNCNTCCCTGCGCATGTTTCACCT
GGGCCGCACCGACACCATCCGCTCGGCTTCCATGGACTCACTCACCTTTGTCAAGGCCAT
GGATGACTCCAGCGTCACGGAGCACCAGAAGGTGGAGCTGCTGCGGAAGGCCGTGCAGGC
CCACCGGGGCTACACCGACCGGGCCATCCGCGGGGAGGCCTTTGGTCGACACCTGCTGGG
CCTGAAGCTGCAGGCCATCGAGGACCTGGTGAGCACGCCCGACATCTTCATGGACACCTC
CTACGCCATCGCCATGCACTTCCACCTCTCCACCAGCCAGGTCCCTGCCAAGACAGACTG
TGTCATGTTCTTCGGGCCCGTGGTCCCCGACGGCTACGGTGTCTGCTATAACCCCATGGA
GGCCCACATCAACTTCTCCCTGTCGGCCTACAACAGCTGCGCGGAGACCAACGCCGCCCG
CCTGGCGCATTACCTGGAGAAGGCGCTCCTGGACATGCGTGCCCTGCTGCAGAGCCACCC
CCGGGCCAAGCTCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X78706

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_1_Locus:
9q34.1

# Metabolic_Enzyme_1_SNPs:
rs17459086; rs16930895; rs2296770; rs1127926; rs4836635; rs2229419; rs2296771; rs3780691; rs17481672; rs17486052; rs17486213; rs1044555; rs3118638; rs3124498; rs4837340; rs10819462; rs7866897; rs746872; rs2148852; rs746873; rs3780690; rs746874; rs3124499; rs10988204; rs1359845; rs2768630; rs12005112; rs1977447; rs2274476; rs2274477; rs10819463; rs3739842; rs12553915; rs4836636; rs17508619; rs2274478; rs4837337; rs17508557; rs17486066; rs10988202; rs17486199; rs10988203; rs6478862; rs746871; rs17508564; rs17486122; rs17481651; rs7042928; rs10739741; rs3124495; rs3124496; rs7046990; rs3118639; rs11564078; rs12342825; rs10988200; rs13289043; rs17481561; rs17508516; rs7032146; rs17433234; rs17486038; rs1044553; rs3118635; rs1127927; rs1044554; rs3184394; rs1044560; rs17508708; rs17486059; rs11559172; rs17508701; rs17455684; rs34939838; rs2768629; rs34873985; rs12350395; rs17508605; rs34349125; rs17508668; rs17481644; rs17486178; rs17486192; rs17508577; rs17508675; rs17459128; rs10988207; rs17433297; rs17433262; rs3780689; rs36193924; rs2182730; rs4837336; rs10549379; rs17486073; rs17459135; rs17486185; rs36010531; rs34018398; rs17486136; rs3896405; rs35228713; rs719494; rs11397782; rs17508598; rs17481631; rs1410014; rs4837338; rs17459142; rs4080490; rs17508654; rs17459121; rs3118636; rs17486094; rs1410015; rs17486164; rs17508647; rs17481638; rs17508695; rs17455705; rs17508689; rs3118637; rs12336784; rs3750337; rs10988208; rs17455698; rs11314279; rs41276750; rs10988201; rs7042713; rs34420023; rs12341709; rs17508509; rs3124497; rs28365572; rs17455671; rs17455678; rs35668864; rs17508523; rs34313463; rs35783610; rs10760588; rs10819464; rs10819469; rs10988209; rs11564083; rs11564084; rs11564085; rs11564095; rs12006010; rs12337663; rs12342022; rs12342339; rs17486220; rs2274475; rs2541162; rs2541163; rs2541164; rs2541165; rs3118624; rs3118625; rs3118626; rs3124501; rs3124502; rs3124503; rs3739843; rs3750335; rs3750336; rs3814492; rs3824536; rs6478861; rs6478864; rs7024821; rs7033128; rs7038362; rs7042563; rs7046842; rs7046961; rs7849160; rs7849270; rs7859344; rs7865067

# Metabolic_Enzyme_1_General_References:
7829107; 7945262

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5254

# Metabolic_Enzyme_2_Name:
Choline O-acetyltransferase

# Metabolic_Enzyme_2_Synonyms:
CHOACTase; Choline acetylase; ChAT

# Metabolic_Enzyme_2_Gene_Name:
CHAT

# Metabolic_Enzyme_2_Protein_Sequence:
>Choline Oacetyltransferase
MGLRTAKKRGLGGGGKWKREEGGGTRGRREVRPACFLQSGGRGDPGDVGGPAGNPGCSPH
PRAATRPPPLPAHTPAHTPEWCGAASAEAAEPRRAGPHLCIPAPGLTKTPILEKVPRKMA
AKTPSSEESGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQ
QKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLIS
GVLSYKALLDSHSIPTDCAKGQLSGQPLCMKQYYGLFSSYRLPGHTQDTLVAQNSSIMPE
PEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNEDERLPPIGLLTSDGRSE
WAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANR
WYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMTQSSRKLIRADSVSELPAP
RRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQ
LAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLL
KDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCKELPEMFMDETYLMSNRFVLSTSQV
PTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCKETSSSKFAKAVEESLIDMRD
LCSLLPPTESKPLATKEKATRPSQGHQP

# Metabolic_Enzyme_2_Number_of_Residues:
748

# Metabolic_Enzyme_2_Molecular_Weight:
82569

# Metabolic_Enzyme_2_Theoretical_pI:
8.69

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses

# Metabolic_Enzyme_2_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_2_Reaction:
acetyl-CoA + choline = CoA + O-acetylcholine

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00755:Carn_acyltransf

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.3.1.6

# Metabolic_Enzyme_2_GenBank_ID_Protein:
301096

# Metabolic_Enzyme_2_SwissProt_ID:
CLAT_HUMAN (P28329)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
CHAT

# Metabolic_Enzyme_2_Geneatlas_id:
CHAT

# Metabolic_Enzyme_2_hgnc_id:
HGNC:1912

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>2247 bp
ATGGGGCTGAGGACAGCGAAGAAGAGGGGGCTTGGGGGAGGGGGGAAATGGAAGAGAGAG
GAGGGAGGAGGTACAAGAGGAAGGAGAGAAGTGCGGCCAGCTTGCTTTCTCCAGTCGGGT
GGCCGCGGGGACCCGGGCGACGTCGGAGGCCCTGCCGGGAACCCAGGCTGCAGCCCCCAC
CCCCGCGCTGCGACACGCCCCCCACCCCTTCCGGCTCACACCCCCGCCCACACTCCTGAG
TGGTGCGGTGCAGCGTCGGCCGAGGCAGCAGAGCCGAGGAGAGCAGGTCCACACCTCTGC
ATCCCTGCACCAGGACTCACCAAGACGCCCATCCTGGAAAAGGTCCCCCGTAAGATGGCA
GCAAAAACTCCCAGCAGTGAGGAGTCTGGGCTGCCCAAACTGCCCGTGCCCCCGCTGCAG
CAGACCCTGGCCACGTACCTGCAGTGCATGCGACACTTGGTGTCTGAGGAGCAGTTCAGG
AAGAGCCAGGCCATTGTGCAGCAGTTTGGGGCCCCTGGTGGCCTCGGCGAGACCCTGCAG
CAGAAACTCCTGGAGCGGCAGGAGAAGACAGCCAACTGGGTGTCTGAGTACTGGCTGAAT
GACATGTATCTCAACAACCGCCTGGCCCTGCCTGTCAACTCCAGCCCTGCCGTGATCTTT
GCTCGGCAGCACTTCCCTGGCACCGATGACCAGCTGAGGTTTGCAGCCAGCCTCATCTCT
GGTGTACTCAGCTACAAGGCCCTGCTGGACAGCCACTCCATTCCCACTGACTGTGCCAAA
CCGGAGCTGTCAGGGCAGCCCCTTTGCATGAAGCAATACTATGGGCTCTTCTCCTCCTAC
CGGCTCCCCGGCCATACCCAGGACACGCTGGTGGCTCAGAACAGCAGCATCATGCCGGAG
CCTGAGCACGTCATCGTAGCCTGCTGCAATCAGTTCTTTGTCTTGGATGTTGTCATTAAT
TTCCGCCGTCTCAGTGAGGGGGATCTGTTCACTCAGTTGAGAAAGATAGTCAAAATGGCT
TCCAACGAGGACGAGCGTTTGCCTCCAATTGGCCTGCTGACGTCTGACGGGAGGAGCGAG
TGGGCCGAGGCCAGGACGGTCCTCGTGAAAGACTCCACCAACCGGGACTCGCTGGACATG
ATTGAGCGCTGCATCTGCCTTGTATGCCTGGACGGCCCAGGAGGCGTGGAGCTCAGCGAC
ACCCACAGGGCACTCCAGCTCCTTCACGGCGGAGGCTACAGCAAGAACGGGGCCAATCGC
TGGTACGACAAGTCCCTGCAGTTTGTGGTGGGCCGAGACGCGACCTGCGGTGTGGTGTGC
GAACACTCCCCATTCGATGGCATCGTCCTGGTGCAGTGCACTGAGCATCTGCTCAAGCAC
ATGACGCAGAGCAGCAGGAAGCTGATCCGAGCAGACTCCGTCAGCGAGCTCCCCGCCCCC
CGGAGGCTGCGGTGGAAATGCTCCCCGGAAATTCAAGGCCACTTAGCCTCCTCGGCAGAA
AAACTTCAACGAATAGTAAAGAACCTTGACTTCATTGTCTATAAGTTTGACAACTATGGG
AAAACATTCATTAAGAAGCAGAAATGCAGCCCTGATGCCTTCATCCAGGTGGCCCTCCAG
CTGGCCTTCTACAGGCTCCACCGAAGACTGGTGCCCACCTACGAGAGCGCGTCCATCCGC
CGATTCCAGGAGGGACGCGTGGACAACATCAGATCGGCCACTCCAGAGGCACTGGCTTTT
GTGAGAGCCGTGACTGACCACAAGGCTGCTGTGCCAGCTTCTGAGAAGCTTCTGCTCCTG
AAGGATGCCATCCGTGCCCAGACTGCATACACAGTCATGGCCATAACAGGGATGGCCATT
GACAACCACCTGCTGGCACTGCGGGAGCTGGCCCGGGCCATGTGCAAGGAGCTGCCCGAG
ATGTTCATGGATGAAACCTACCTGATGAGCAACCGGTTTGTCCTCTCCACTAGCCAGGTG
CCCACAACCACGGAGATGTTCTGCTGCTATGGTCCTGTGGTCCCAAATGGGTATGGTGCC
TGCTACAACCCCCAGCCAGAGACCATCCTTTTCTGCATCTCTAGCTTTCACAGCTGCAAA
GAGACTTCTTCTAGCAAGTTTGCAAAAGCTGTGGAAGAAAGCCTCATTGACATGAGAGAC
CTCTGCAGTCTGCTGCCGCCTACTGAGAGCAAGCCATTGGCAACAAAGGAAAAAGCCACG
AGGCCCAGCCAGGGACACCAACCTTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
S56138

# Metabolic_Enzyme_2_Chromosome_Location:
Not Available

# Metabolic_Enzyme_2_Locus:
Not Available

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
1337937; 11172068; 1388731; 1339386; 1784419

# Metabolic_Enzyme_2_References:
2215852; 7773683; 8187841; 8666027

# Macromolecular_Interacting_Partner_1_ID:
7431

# Macromolecular_Interacting_Partner_1_Name:
Protachykinin 1 precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
PPT[Contains: Substance P; Neurokinin A; NKA; Substance K; Neuromedin L; Neuropeptide K; NPK; Neuropeptide gamma; C-terminal-flanking peptide]

# Macromolecular_Interacting_Partner_1_Gene_Name:
TAC1

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Protachykinin 1 precursor
MKILVALAVFFLVSTQLFAEEIGANDDLNYWSDWYDSDQIKEELPEPFEHLLQRIARRPK
PQQFFGLMGKRDADSSIEKQVALLKALYGHGQISHKRHKTDSFVGLMGKRALNSVAYERS
AMQNYERRR

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
129

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
15003

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
9.38

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cell-cell signaling
Process:  transmission of nerve impulse
Process:  synaptic transmission
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
Process:  tachykinin signaling pathway
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF02202:Tachykinin

# Macromolecular_Interacting_Partner_1_Signals:
1-19

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
29483

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
TKN1_HUMAN (P20366)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
TAC1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
TAC1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:11517

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>390 bp
ATGAAAATCCTCGTGGCCTTGGCAGTCTTTTTTCTTGTCTCCACTCAGCTGTTTGCAGAA
GAAATAGGAGCCAATGATGATCTGAATTACTGGTCCGACTGGTACGACAGCGACCAGATC
AAGGAGGAACTGCCGGAGCCCTTTGAGCATCTTCTGCAGAGAATCGCCCGGAGACCCAAG
CCTCAGCAGTTCTTTGGATTAATGGGCAAACGGGATGCTGATTCCTCAATTGAAAAACAA
GTGGCCCTGTTAAAGGCTCTTTATGGACATGGCCAGATCTCTCACAAAAGACATAAAACA
GATTCCTTTGTTGGACTAATGGGCAAAAGAGCTTTAAATTCTGTGGCTTATGAAAGGAGT
GCAATGCAGAATTATGAAAGAAGACGTTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
X54469

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_1_Locus:
7q21-q22

# Macromolecular_Interacting_Partner_1_SNPs:
rs2072100; rs12532490; rs12534885; rs4602814; rs1229434; rs1397202; rs4526299; rs2072099; rs3779470; rs4598190; rs7795107; rs1510300; rs11974592; rs2051794; rs7793277; rs17169049; rs11554502; rs6971011; rs11554503; rs6971427; rs1802867; rs15575; rs34326418; rs34707813; rs28740842; rs2189306; rs28475844; rs3058356; rs10602908; rs28674851; rs5886042; rs34560734; rs11320559; rs10247565; rs1229438; rs1229440; rs1237992; rs13232655; rs1510302; rs1510303; rs6465606; rs6465608; rs6945396; rs6962048

# Macromolecular_Interacting_Partner_1_General_References:
3770210; 1708336; 3038549; 2284201

# Macromolecular_Interacting_Partner_1_References:
1284499; 16425616; 7538169

# Macromolecular_Interacting_Partner_2_ID:
8080

# Macromolecular_Interacting_Partner_2_Name:
Beta-nerve growth factor precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Beta-NGF

# Macromolecular_Interacting_Partner_2_Gene_Name:
NGFB

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Betanerve growth factor precursor
MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIA
ARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSK
RSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCR
DPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRR
A

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
241

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
26959

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
10.54

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00243:NGF

# Macromolecular_Interacting_Partner_2_Signals:
1-18

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
671883

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
NGF_HUMAN (P01138)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
NGFB

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
NGFB

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:7808

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>726 bp
ATGTCCATGTTGTTCTACACTCTGATCACAGCTTTTCTGATCGGCATACAGGCGGAACCA
CACTCAGAGAGCAATGTCCCTGCAGGACACACCATCCCCCAAGTCCACTGGACTAAACTT
CAGCATTCCCTTGACACTGCCCTTCGCAGAGCCCGCAGCGCCCCGGCAGCGGCGATAGCT
GCACGCGTGGCGGGGCAGACCCGCAACATTACTGTGGACCCCAGGCTGTTTAAAAAGCGG
CGACTCCGTTCACCCCGTGTGCTGTTTAGCACCCAGCCTCCCCGTGAAGCTGCAGACACT
CAGGATCTGGACTTCGAGGTCGGTGGTGCTGCCCCCTTCAACAGGACTCACAGGAGCAAG
CGGTCATCATCCCATCCCATCTTCCACAGGGGCGAATTCTCGGTGTGTGACAGTGTCAGC
GTGTGGGTTGGGGATAAGACCACCGCCACAGACATCAAGGGCAAGGAGGTGATGGTGTTG
GGAGAGGTGAACATTAACAACAGTGTATTCAAACAGTACTTTTTTGAGACCAAGTGCCGG
GACCCAAATCCCGTTGACAGCGGGTGCCGGGGCATTGACTCAAAGCACTGGAACTCATAT
TGTACCACGACTCACACCTTTGTCAAGGCGCTGACCATGGATGGCAAGCAGGCTGCCTGG
CGGTTTATCCGGATAGATACGGCCTGTGTGTGTGTGCTCAGCAGGAAGGCTGTGAGAAGA
GCCTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V01511

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_2_Locus:
1p13.1

# Macromolecular_Interacting_Partner_2_SNPs:
rs6330; rs11466110; rs11466111; rs6325; rs1318345; rs2747058; rs719452; rs2179926; rs2254404; rs2856813; rs910330; rs2239622; rs10776800; rs2254527; rs3811015; rs4332358; rs10776798; rs4454548; rs4839028; rs4073129; rs4076194; rs4839435; rs4146585; rs6678788; rs4839436; rs6326; rs12082544; rs6328; rs6698675; rs7540561; rs6537860; rs4240542; rs7544068; rs4529705; rs7542555; rs4075872; rs11102929; rs2747063; rs10745349; rs7535026; rs10776799; rs2268792; rs6673867; rs4565713; rs4626883; rs2268793; rs4076018; rs2300692; rs6331; rs6686615; rs10858075; rs12402406; rs11466098; rs17540656; rs4573519; rs10858072; rs10489530; rs12060354; rs7516191; rs11466100; rs11102924; rs7530686; rs3730194; rs2856811; rs10776797; rs12026714; rs11102925; rs17033706; rs7513144; rs4298728; rs17033692; rs17033685; rs10442682; rs11102919; rs12067817; rs4382725; rs4567277; rs3738701; rs11102917; rs11466085; rs11102926; rs7544163; rs7523654; rs17033688; rs10858074; rs4634908; rs2300694; rs7520839; rs11466069; rs11466104; rs11466091; rs11466073; rs4240543; rs11466103; rs11466089; rs11466083; rs11466102; rs12026809; rs11102920; rs12145726; rs12048019; rs11466076; rs11102916; rs11466070; rs10442681; rs6678898; rs11466068; rs11466075; rs12061479; rs7415422; rs11466099; rs7555016; rs11466093; rs6658541; rs11466077; rs17033622; rs11466079; rs11466095; rs2300693; rs11466094; rs4623700; rs10858071; rs11466106; rs11466109; rs12058002; rs11466097; rs11466074; rs3811016; rs12061661; rs17033680; rs2300695; rs11466108; rs4644491; rs11102922; rs4406631; rs12058927; rs11466072; rs12091513; rs12060360; rs11466071; rs4298730; rs11466081; rs11466086; rs10858073; rs11466080; rs11102921; rs11102927; rs7536097; rs12760036; rs11102918; rs11466087; rs11466096; rs11466084; rs4320778; rs11584438; rs4348722; rs4456091; rs4839434; rs6329; rs7417254; rs11466088; rs10158276; rs4240544; rs11466082; rs3811014; rs10776801; rs11102930; rs11466113; rs11466066; rs11466063; rs11466065; rs11466062; rs34542615; rs28758211; rs11466112; rs34079702; rs35941329; rs11466092; rs12727497; rs35833423; rs11579116; rs35290932; rs11302114; rs2284830; rs12749420; rs3730184; rs28645283; rs2747059; rs11466090; rs35070942; rs11102923; rs12088144; rs35067920; rs11102928; rs11580846; rs35755250; rs11466107; rs34024301; rs12023088; rs28735771; rs28461336; rs11579131; rs34357271; rs34257515; rs11579114; rs35884898; rs12025459; rs12119346; rs35221274; rs35274060; rs12073677; rs12070188; rs11584424; rs35329343; rs34377570; rs11485078; rs3730215; rs35658308; rs3021067; rs4417063; rs12731678; rs2747061; rs35447405; rs12047130; rs11579133; rs13374803; rs35225488; rs9970214; rs719451; rs7528234; rs2747056; rs2856814; rs10157426; rs12731680; rs11466078; rs2747055; rs35917469; rs35011726; rs35337130; rs35044546; rs17033682; rs28505352; rs34063775; rs2856812; rs35439338; rs11466105; rs34845120; rs11586039; rs34042023; rs35071824; rs34402529; rs2747057; rs11466114; rs35603764; rs11466064; rs11466061; rs11466067; rs34611363; rs3841009; rs10776802; rs10858076; rs10858077; rs10858078; rs11102915; rs11102932; rs11466059; rs11583020; rs11805062; rs11807499; rs12074502; rs12075799; rs12085129; rs12139760; rs12723944; rs1474798; rs1535093; rs1555207; rs17033589; rs17033597; rs17033602; rs17033725; rs2068797; rs2982740; rs2982741; rs2982742; rs3014804; rs4073110; rs4131272; rs4131273; rs4310443; rs4418592; rs4504888; rs4839029; rs4839030; rs4839031; rs6327; rs6656381; rs6657711; rs6676284; rs6678944; rs6691765; rs7416420; rs7523086; rs7523831; rs7532754; rs7544256; rs926781

# Macromolecular_Interacting_Partner_2_General_References:
6688123; 6327169; 2374737; 10322959; 2025430; 10391209

# Macromolecular_Interacting_Partner_2_References:
12110958; 12689602; 1324679; 1655307

# Macromolecular_Interacting_Partner_3_ID:
8055

# Macromolecular_Interacting_Partner_3_Name:
Tumor necrosis factor receptor superfamily member 16 precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
Low- affinity nerve growth factor receptor; NGF receptor; Gp80-LNGFR; p75 ICD; Low affinity neurotrophin receptor p75NTR; CD271 antigen

# Macromolecular_Interacting_Partner_3_Gene_Name:
NGFR

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Tumor necrosis factor receptor superfamily member 16 precursor
MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGAN
QTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTG
RCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLREC
TRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQ
PVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEK
LHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWR
HLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSE
STATSPV

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
427

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
45184

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
4.32

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  binding
Function:  protein binding
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00531:Death;
PF00020:TNFR_c6

# Macromolecular_Interacting_Partner_3_Signals:
1-28

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
251-272

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
189205

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
TNR16_HUMAN (P08138)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
NGFR

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
NGFR

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:7809

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1284 bp
ATGGGGGCAGGTGCCACCGGCCGCGCCATGGACGGGCCGCGCCTGCTGCTGTTGCTGCTT
CTGGGGGTGTCCCTTGGAGGTGCCAAGGAGGCATGCCCCACAGGCCTGTACACACACAGC
GGTGAGTGCTGCAAAGCCTGCAACCTGGGCGAGGGTGTGGCCCAGCCTTGTGGAGCCAAC
CAGACCGTGTGTGAGCCCTGCCTGGACAGCGTGACGTTCTCCGACGTGGTGAGCGCGACC
GAGCCGTGCAAGCCGTGCACCGAGTGCGTGGGGCTCCAGAGCATGTCGGCGCCGTGCGTG
GAGGCCGACGACGCCGTGTGCCGCTGCGCCTACGGCTACTACCAGGATGAGACGACTGGG
CGCTGCGAGGCGTGCCGCGTGTGCGAGGCGGGCTCGGGCCTCGTGTTCTCCTGCCAGGAC
AAGCAGAACACCGTGTGCGAGGAGTGCCCCGACGGCACGTATTCCGACGAGGCCAACCAC
GTGGACCCGTGCCTGCCCTGCACCGTGTGCGAGGACACCGAGCGCCAGCTCCGCGAGTGC
ACACGCTGGGCCGACGCCGAGTGCGAGGAGATCCCTGGCCGTTGGATTACACGGTCCACA
CCCCCAGAGGGCTCGGACAGCACAGCCCCCAGCACCCAGGAGCCTGAGGCACCTCCAGAA
CAAGACCTCATAGCCAGCACGGTGGCAGGTGTGGTGACCACAGTGATGGGCAGCTCCCAG
CCCGTGGTGACCCGAGGCACCACCGACAACCTCATCCCTGTCTATTGCTCCATCCTGGCT
GCTGTGGTTGTGGGCCTTGTGGCCTACATAGCCTTCAAGAGGTGGAACAGCTGCAAGCAG
AACAAGCAAGGAGCCAACAGCCGGCCAGTGAACCAGACGCCCCCACCAGAGGGAGAAAAA
CTCCACAGCGACAGTGGCATCTCCGTGGACAGCCAGAGCCTGCATGACCAGCAGCCCCAC
ACGCAGACAGCCTCGGGCCAGGCCCTCAAGGGTGACGGAGGCCTCTACAGCAGCCTGCCC
CCAGCCAAGCGGGAGGAGGTGGAGAAGCTTCTCAACGGCTCTGCGGGGGACACCTGGCGG
CACCTGGCGGGCGAGCTGGGCTACCAGCCCGAGCACATAGACTCCTTTACCCATGAGGCC
TGCCCCGTTCGCGCCCTGCTTGCAAGCTGGGCCACCCAGGACAGCGCCACACTGGACGCC
CTCCTGGCCGCCCTGCGCCGCATCCAGCGAGCCGACCTCGTGGAGAGTCTGTGCAGTGAG
TCCACTGCCACATCCCCGGTGTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
M14764

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_3_Locus:
17q21-q22

# Macromolecular_Interacting_Partner_3_SNPs:
rs2072446; rs11466155; rs734194; rs7219709; rs741071; rs7224806; rs741073; rs3729672; rs11466164; rs741072; rs9675008; rs11466171; rs11466166; rs11650067; rs11466162; rs11466174; rs11466126; rs11466165; rs11466173; rs11466161; rs1804011; rs613495; rs2072444; rs534561; rs4239164; rs9908234; rs614455; rs2537706; rs2671639; rs575791; rs600120; rs627905; rs565042; rs2537701; rs3729670; rs11079872; rs2584659; rs4794056; rs9895558; rs2584653; rs11466153; rs3785930; rs11466157; rs11466144; rs2072445; rs3785931; rs601910; rs11466134; rs11466141; rs11466151; rs11466143; rs11466149; rs563205; rs11466127; rs651039; rs11466128; rs12450859; rs9303553; rs11466131; rs11466150; rs11466138; rs11466160; rs11466137; rs11466140; rs8070614; rs11466145; rs11466148; rs11466159; rs2584674; rs2584685; rs11466154; rs11466129; rs558481; rs11466130; rs657770; rs11466152; rs11466133; rs11466124; rs11466123; rs11466118; rs11466117; rs17854609; rs3729671; rs28730666; rs11466168; rs1801300; rs1042549; rs11556130; rs5820764; rs11466167; rs11466170; rs11466172; rs11466163; rs5820763; rs34854378; rs41491145; rs10672288; rs10664339; rs11466156; rs10626377; rs35619922; rs8071230; rs2537707; rs11466142; rs9898165; rs35024840; rs35879792; rs2458670; rs2439829; rs34271464; rs35193805; rs11466132; rs12942872; rs9905594; rs34331769; rs11466136; rs11466135; rs2671638; rs28501168; rs2439828; rs28730834; rs11466158; rs7217056; rs41523847; rs11656643; rs12945007; rs11654558; rs28624293; rs11466125; rs34146703; rs11466121; rs11656191; rs11466122; rs11466120; rs11466119; rs11656143; rs1035050; rs10491195; rs11466175; rs11466176; rs11466177; rs12451987; rs12938443; rs12938748; rs16948196; rs16948200; rs1860888; rs2537708; rs2537710; rs2537712; rs2584665; rs2671641; rs2671642; rs2671643; rs2671645; rs2671646; rs2671681; rs2671682; rs2671683; rs2671684; rs2671686; rs2671687; rs2671688; rs2671689; rs4257247; rs489484; rs584589; rs585916; rs603769; rs719759; rs7225781; rs8081715; rs885370; rs885371; rs9904949; rs9909453; rs9914132

# Macromolecular_Interacting_Partner_3_General_References:
3022937; 2850481; 10514511; 9915784; 10544233; 12963025; 8627329

# Macromolecular_Interacting_Partner_3_References:
1655307

End of HMDB00201

Beginning of HMDB00202
# Accession_No:
HMDB00202

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-18 10:45:37

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Methylmalonic acid

# Description:
A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.

# Synonyms:
1,1-Ethanedicarboxylate; 1,1-Ethanedicarboxylic acid; 2-Methylmalonate; 2-Methylmalonic acid; Isosuccinate; Isosuccinic acid; Methylmalonate; Methylmalonic acid; Methylpropanedioate; Methylpropanedioic acid; methyl-Malonate; methyl-Malonic acid; methyl-Propanedioate; methyl-Propanedioic acid

# Chemical_IUPAC_Name:
2-methylpropanedioic acid

# Chemical_Formula:
C4H6O4

# Chemical_Structure:
tbl_chemical:::HMDB00202_ZOOM.png:::119283249589780267

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00202_THUMB.png:::119283249433368667

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
carboxylic acid

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
118.02661

# Molecular_Weight_Avg:
118.08804

# Smiles_String_isomeric:
CC(C(O)=O)C(O)=O

# Smiles_String_canonical:
CC(C(O)=O)C(O)=O

# KEGG_Compound_ID:
C02170

# BioCyc_ID:
Not Available

# PubChem_CID:
487

# PubChem_SID:
86442; 10358223; 5992023; 8145370; 587340; 5245; 3133914; 10524907; 153879; 8150664; 2437

# OMIM_ID:
236270; 250940; 251000; 251100; 251110; 251120; 275350; 277380; 277400; 277410; 600089; 603178; 606169

# Metagene_ID:
MALONYL-COA DECARBOXYLASE DEFICIENCY: 28; METHYLMALONIC ACIDURIA, cblA TYPE: 328; METHYLMALONIC ACIDURIA, ISOLATED, BENIGN (BACTERIAL OVERGROWTH?): 283; COMBINED DEF. OF 5-DEOXYADENOSYLCOBALAMIN AND METHYLCOBALAMIN (clbC, clbD, clbF): 142; MAMEL (METHYLMALONIC ACIDURIA MITOCHONDRIAL ENCEPHELOPATHY LEIGH-LIKE) A NEW MITOCHONDRIAL ENCEPHALOPATHY: 518; METHYLMALONIC ACIDURIA, cblB TYPE: 517; METHYLMALONIC ACIDURIA, ATYPICAL: 368; TRANSCOBALAMIN II DEFICIENCY: 323; FEEDING: VEGANIAN [DD]: 336; METHYLMALONIC ACIDURIA (MMA): 15; VITAMIN B(12) MALABSORPTION. ANEMIA, PERNICOUS, JUVENILE. COBALAMIN MALABSORPTION: 22; COBALAMIN MALABSORPTION: 329; METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY: 485

# BiGG_ID:
Not Available

# Wikipedia_ID:
Methylmalonic acid

# METLIN_ID:
3712

# Ref_ID:
9669477; 11067816; 1261058; 6467607; 1779612; 8087979; 12894427; 15902554; 3700655; 4557757; 319293; 12814169; 1444166; 500809; 830370

# ChEBI_ID:
17453

# CAS_Registry_Number:
516-05-2

# InChI:
InChI=1/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8)

# Synthesis_Reference:
Fully regioselective catalytic carbonylation of acrylic derivatives:  synthesis of methylmalonic acid by iron pentacarbonyl-catalyzed hydrocarboxylation of acrylic acid.     Brunet, Jean Jacques; Passelaigue, Elisabeth.    Lab. Chim. Coord.,  CNRS,  Toulo

# Melting_Point:
135 oC

# Melting_Point_predicted:
28.8 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
679.0 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
149.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
0.18 [Predicted by ALOGPS]; -0.1 [Predicted by PubChem via XLOGP]; -0.83 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Methylmalonic acid.pdf:::1132562215931416922

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Methylmalonic_acid.mol:::1132723813671221466

# SDF_File_[Text]:
tbl_chemical:::HMDB00202.sdf:::119283249103422453

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00202.pdb:::119283249296518294

# PDB_ID:
1CW8

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::050117_P00_09_BA_1DP_presat_expanded_2.gif:::114168246342654591

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::050117_P00_09_BA_1DP_presat.zip:::1175124361942774561

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050117_P00_09_BA_1DP_Assigned.png:::114667869624871602

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::050117_P00_09_BA_1DC_130.jpg:::114168392219078951

# C_NMR_FIDS_Spectra:
tbl_cnmr:::050117_P00_09_BA_1DC_130.zip:::114168392214880617

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::050117_P00_09_BA_1DC_130_Assigned.jpg:::114355747494341885

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050117_P00_09_BA_2DHSQC_484.jpg:::11461760098903929

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050117_P00_09_BA_2DHSQC_484.zip:::114617601053055142

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050117_P00_09_BA_2DHSQC_484_Assigned.jpg:::114781387946429547

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Methylmalonic acid.gif:::113273212181267788

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00202_peaks.txt:::1156309615587288168

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Methylmalonic acid_C.gif:::1132737722120790488

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00202_peaks.txt:::1156310804817882159

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00202L.png:::11755526338682749; Medium Energy:tbl_ms:::HMDB00202M.png:::117555268604399422; High Energy:tbl_ms:::HMDB00202H.png:::117555271913879632

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP)

# Tissue_Location:
Kidney; Liver

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	1.8 (0.00-3.6)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	11067816
Urine	0-3.6	umol/mmol_creatinine	Adult:>18_yrs_old	N/A	Normal	11067816
Urine	9.4 (0.1-79.4)	umol/mmol_creatinine	Newborn:0-30_days_old	N/A	Normal	8087979
Urine	29.9 (0.1-78.9)	umol/mmol_creatinine	Infant:0-1_yr_old	N/A	Normal	8087979
Urine	4.8 (1.6-24.9)	umol/mmol_creatinine	Children:1-13_yrs_old	N/A	Normal	8087979
Urine	8.2 (1.5-30.8)	umol/mmol_creatinine	Children:1-13_yrs_old	N/A	Normal	8087979
Urine	3.7 (1.1-21.6)	umol/mmol_creatinine	Children:1-13_yrs_old	N/A	Normal	8087979
Blood	0.14 (0.04-0.26)	umol/L	Adult:>18_yrs_old	Both	Normal	8412012
Blood	0.200 (0.00-0.400)	uM	Adult:>18_yrs_old	N/A	Normal	11067816
Cerebrospinal_Fluid(CSF)	0.51 +/- 0.13 	uM	Adult:>18_yrs_old	Both	Normal	16227558
Cerebrospinal_Fluid(CSF)	0.32 +/- 0.11 	umol/L	Adult:>18_yrs_old	Both	Normal	16227558


# Concentration_[Abnormal]:
Blood	254000.0	umol/L	Adult:>18_yrs_old	Both	Methylmalonic acidemia	4557757
Blood	22.0 (4.3-37.0)	umol/L	Adult:>18_yrs_old	Both	Cobalamin deficiency	8412012
Cerebrospinal_Fluid(CSF)	296.4 +/- 118.5	N/A	Elderly:>65_yrs_old	N/A	Alzheimer's disease	16227558


# Associated_Disorders:
Adenosylcobalamin Deficiency (CBLA, CBLB); Alzheimer's disease; Anemia, Pernicous, Juvenile; Cachexia; Cobalamin Deficiency; Cobalamin Malabsorption; Combined defect of 5-Deoxyadenosylcobalamin and Methylcobalamin (CLBC, CLBD, CLBF); Liver Disease; Malonyl-Coa Decarboxylase Deficiency; Methylmalonate Semialdehyde Dehydrogenase Deficiency; Methylmalonic Acidemia; Methylmalonic Aciduria (MMA); Methylmalonic Aciduria, Isolated, Benign (Bacterial Overgrowth?); Transcobalamin II Deficiency; Vitamin B12 Malabsorption

# Pathway_Names:
Lysine degradation;Glycolysis;Valine, leucine and isoleucine degradation;Vitamin B6 metabolism;Nicotinate and nicotinamide metabolism;Fatty acid metabolism;Bile acid biosynthesis;Glycerolipid metabolism;Pyruvate metabolism;Propanoate metabolism;Butanoate metabolism;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
Lysine_degradation.jpg;Glycolysis.jpg;valine,leucine,and_isoleucine_degradation.jpg;;Nicotinamide_synthesis_(NADH).jpg;;;;;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00310;map00010;map00280;map00750;map00760;map00071;map00120;map00561;map00620;map00640;map00650;map00280;map00280

# Pathway_Graphs:
Lysine_degradation_Graph.jpg;Glycolysis_Graph.jpg;valine,leucine,and_isoleucine_degradation_Graph.jpg;;Nicotinamide_synthesis_(NADH)_Graph.jpg;;;;;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
Lysine_degradation.xml;Glycolysis.xml;valine,leucine,and_isoleucine_degradation.xml;;Nicotinamide_synthesis_(NADH).xml;;;;;;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5526

# Metabolic_Enzyme_1_Name:
4-trimethylaminobutyraldehyde dehydrogenase

# Metabolic_Enzyme_1_Synonyms:
TMABADH; Aldehyde dehydrogenase 9A1; Aldehyde dehydrogenase E3 isozyme; Gamma-aminobutyraldehyde dehydrogenase; R- aminobutyraldehyde dehydrogenase

# Metabolic_Enzyme_1_Gene_Name:
ALDH9A1

# Metabolic_Enzyme_1_Protein_Sequence:
>4trimethylaminobutyraldehyde dehydrogenase
MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA
AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY
AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK
PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI
MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI
LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY
VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA
AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL
KTVCVEMGDVESAF

# Metabolic_Enzyme_1_Number_of_Residues:
494

# Metabolic_Enzyme_1_Molecular_Weight:
53802

# Metabolic_Enzyme_1_Theoretical_pI:
5.61

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction

# Metabolic_Enzyme_1_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_1_Reaction:
4-trimethylammoniobutanal + NAD+ = 4-trimethylammoniobutanoate + NADH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.2.1.47;EC 1.2.1.3;EC

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1049219

# Metabolic_Enzyme_1_SwissProt_ID:
AL9A1_HUMAN (P49189)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ALDH9A1

# Metabolic_Enzyme_1_Geneatlas_id:
ALDH9A1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:412

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1482 bp
ATGAGCACTGGCACCTTCGTCGTGTCGCAGCCGCTCAATTACCGCGGCGGGGCCGCTGGA
GCCGGCGGACGCTCCGGTACCGAGAAAGCTTTCGAGCCAGCAACCGGCCGAGTGATAGCT
ACTTTCACATGTTCAGGAGAAAAGGAAGTAAATTTGGCTGTTCAAAATGCAAAGGCTGCT
TTTAAAATATGGAGTCAAAAATCTGGCATGGAGCGTTGCCGAATCCTTTTGGAGGCTGCC
AGGATAATAAGGGAACGGGAGGATGAAATTGCTACTATGGAGTGCATCAACAATGGCAAG
TCCATCTTTGAGGCCCGCTTGGACATTGACATTTCCTGGCAGTGCCTGGAGTATTATGCG
GGCTTGGCTGCATCCATGGCTGGTGAACACATCCAGCTCCCAGGTGGATCGTTTGGTTAT
ACCAGAAGAGAACCACTTGGGGTATGTGTGGGAATAGGAGCATGGAACTACCCCTTTCAG
ATTGCCTCTTGGAAGTCGGCTCCAGCATTAGCCTGTGGTAATGCCATGGTCTTTAAACCT
TCTCCCTTTACACCTGTTTCTGCATTGCTACTGGCTGAAATCTACAGTGAGGCTGGTGTA
CCTCCTGGGCTCTTCAATGTGGTGCAGGGAGGGGCTGCCACAGGCCAGTTTCTGTGTCAG
CATCCCGATGTGGCCAAAGTCTCCTTCACTGGAAGTGTGCCCACTGGCATGAAGATCATG
GAGATGTCAGCTAAAGGAATCAAACCTGTTACCTTGGAACTTGGAGGCAAATCTCCACTC
ATCATCTTCTCAGACTGTGATATGAACAATGCTGTAAAGGGGGCGCTGATGGCCAACTTC
CTCACACAAGGCCAGGTTTGCTGTAATGGCACAAGAGTATTTGTGCAGAAAGAAATTCTT
GATAAATTTACAGAGGAAGTGGTGAAACAGACCCAAAGGATTAAAATTGGAGATCCCCTT
CTGGAAGATACAAGGATGGGTCCACTCATCAACCGACCACACCTGGAGCGAGTCCTTGGG
TTTGTCAAAGTGGCAAAGGAGCAGGGTGCTAAAGTGTTATGTGGTGGAGATATATATGTA
CCTGAAGATCCCAAATTAAAGGATGGATATTACATGAGACCTTGTGTATTAACTAATTGC
AGAGACGACATGACCTGTGTGAAGGAAGAGATCTTTGGGCCTGTTATGTCCATTTTATCA
TTTGACACTGAAGCTGAGGTTCTAGAAAGAGCCAATGATACCACTTTTGGACTAGCAGCT
GGCGTCTTTACCAGGGACATCCAACGGGCTCATAGAGTGGTAGCTGAGCTTCAGGCTGGG
ACGTGCTTCATTAACAACTATAACGTCAGCCCAGTGGAGTTGCCCTTTGGTGGATATAAG
AAGTCAGGATTTGGCAGAGAGAACGGCCGTGTGACAATCGAATATTATTCACAGCTGAAG
ACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U34252

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_1_Locus:
1q23.1

# Metabolic_Enzyme_1_SNPs:
rs1065756; rs11808728; rs1143659; rs11506; rs12670; rs12408101; rs1913844; rs2882006; rs10753688; rs4646891; rs4646889; rs7516126; rs12565874; rs3820362; rs10800129; rs10800128; rs7534437; rs12072634; rs4656457; rs1337442; rs2348728; rs4578194; rs12080699; rs7541817; rs10918239; rs2348727; rs3738192; rs6683969; rs12065621; rs2348734; rs16849230; rs6426930; rs12083232; rs7513998; rs12122497; rs7555787; rs4646886; rs10800127; rs10918252; rs2348729; rs4646883; rs7518869; rs10800133; rs2176151; rs4646882; rs1538115; rs10800131; rs4646897; rs6690818; rs2050619; rs10753689; rs7546084; rs12076579; rs17482717; rs4657463; rs10918235; rs11587760; rs4274037; rs12567331; rs4557947; rs1337443; rs10800130; rs10800132; rs4646895; rs16849238; rs17450889; rs12033254; rs12069198; rs6657651; rs10918245; rs3845537; rs10918237; rs11807857; rs11807866; rs884121; rs4657462; rs10918236; rs7543204; rs2184918; rs12070650; rs17417191; rs9970857; rs6662419; rs7367737; rs10918242; rs10918241; rs7546322; rs4646888; rs16849374; rs12409168; rs12037790; rs10918247; rs7537071; rs12084748; rs10918238; rs7368130; rs2348730; rs10918244; rs4233407; rs12123278; rs4646892; rs4657466; rs4576644; rs6683651; rs6667075; rs12021795; rs6683665; rs12081464; rs7546215; rs7519162; rs10918240; rs6667088; rs6669697; rs12081903; rs4646885; rs7542184; rs16849479; rs4646887; rs12072664; rs10753687; rs4646896; rs10157944; rs6668102; rs3753893; rs4657468; rs3753892; rs7553712; rs7511691; rs7554409; rs7544840; rs6426928; rs6667681; rs4646881; rs1415503; rs11555775; rs9164; rs4646902; rs6667510; rs11555774; rs4307543; rs11436915; rs34948330; rs12139219; rs34495301; rs10918248; rs1890080; rs35894201; rs4646884; rs28759374; rs12137604; rs28589393; rs34662022; rs12354157; rs10918246; rs35087657; rs34105906; rs35913333; rs34664103; rs12083492; rs2271658; rs34872122; rs7512816; rs4646893; rs7527514; rs12566251; rs1970286; rs3831954; rs2348731; rs10918249; rs35178491; rs36027739; rs35864611; rs17416948; rs4646894; rs11583089; rs12742656; rs12754903; rs12742657; rs41267568; rs4646890; rs12084651; rs4646900; rs34304173; rs13376536; rs12727801; rs41326750; rs28439296; rs12134617; rs12036561; rs35531113; rs3845536; rs36011778; rs12090132; rs7525102; rs10918250; rs3738191; rs12239517; rs4646898; rs34072474; rs34945812; rs10918251; rs1890079; rs35439339; rs36150573; rs1577847; rs12728137; rs34846458; rs4646901; rs36110991; rs12083091; rs34894576; rs6426927; rs11458950; rs1856143; rs35757606; rs41267564; rs41267566; rs35742388; rs10494446; rs10494447; rs10800123; rs10800125; rs10800126; rs10800135; rs10800136; rs10918228; rs10918229; rs10918231; rs10918254; rs10918255; rs10918256; rs11579160; rs11800476; rs11810856; rs12027066; rs12028588; rs12043815; rs12044709; rs12060366; rs12143472; rs12748251; rs1547725; rs16848876; rs16848958; rs16849041; rs16849616; rs1878074; rs1878075; rs2090281; rs2297762; rs2297763; rs2297764; rs2297765; rs3753894; rs3795540; rs4147602; rs4147604; rs4147605; rs4147610; rs4147611; rs4341347; rs7527279; rs7549511; rs7551594; rs8133; rs9333483; rs9333487; rs9919190

# Metabolic_Enzyme_1_General_References:
8786138; 10702312; 8645224; 8269919; 2925663

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5527

# Metabolic_Enzyme_2_Name:
Aldehyde dehydrogenase, dimeric NADP-preferring

# Metabolic_Enzyme_2_Synonyms:
ALDH class 3; ALDHIII

# Metabolic_Enzyme_2_Gene_Name:
ALDH3A1

# Metabolic_Enzyme_2_Protein_Sequence:
>Aldehyde dehydrogenase, dimeric NADPpreferring
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH

# Metabolic_Enzyme_2_Number_of_Residues:
453

# Metabolic_Enzyme_2_Molecular_Weight:
50380

# Metabolic_Enzyme_2_Theoretical_pI:
6.52

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes

# Metabolic_Enzyme_2_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_2_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
178402

# Metabolic_Enzyme_2_SwissProt_ID:
AL3A1_HUMAN (P30838)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ALDH3A1

# Metabolic_Enzyme_2_Geneatlas_id:
ALDH3A1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:405

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1362 bp
ATGAGCAAGATCAGCGAGGCCGTGAAGCGCGCCCGCGCCGCCTTCAGCTCGGGCAGGACC
CGTCCGCTGCAGTTCCGATTCCAGCAGCTGGAGGCGCTGCAGCGCCTGATCCAGGAGCAG
GAGCAGGAGCTGGTGGGCGCGCTGGCCGCAGACCTGCACAAGAATGAATGGAACGCCTAC
TATGAGGAGGTGGTGTACGTCCTAGAGGAGATCGAGTACATGATCCAGAAGCTCCCTGAG
TGGGCCGCGGATGAGCCCGTGGAGAAGACGCCCCAGACTCAGCAGGACGAGCTCTACATC
CACTCGGAGCCACTGGGCGTGGTCCTCGTCATTGGCACCTGGAACTACCCCTTCAACCTC
ACCATCCAGCCCATGGTGGGCGCCATCGCTGCAGGGAACGCAGTGGTCCTCAAGCCCTCG
GAGCTGAGTGAGAACATGGCGAGCCTGCTGGCTACCATCATCCCCCAGTACCTGGACAAG
GATCTGTACCCAGTAATCAATGGGGGTGTCCCTGAGACCACGGAGCTGCTCAAGGAGAGG
TTCGACCATATCCTGTACACGGGCAGCACGGGGGTGGGGAAGATCATCATGACGGCTGCT
GCCAAGCACCTGACCCCTGTCACGCTGGAGCTGGGAGGGAAGAGTCCCTGCTACGTGGAC
AAGAACTGTGACCTGGACGTGGCCTGCCGACGCATCGCCTGGGGGAAATTCATGAACAGT
GGCCAGACCTGCGTGGCCCCAGACTACATCCTCTGTGACCCCTCGATCCAGAACCAAATT
GTGGAGAAGCTCAAGAAGTCACTGAAAGAGTTCTACGGGGAAGATGCTAAGAAATCCCGG
GACTATGGAAGAATCATTAGTGCCCGGCACTTCCAGAGGGTGATGGGCCTGATTGAGGGC
CAGAAGGTGGCTTATGGGGGCACCGGGGATGCCGCCACTCGCTACATAGCCCCCACCATC
CTCACGGACGTGGACCCCCAGTCCCCGGTGATGCAAGAGGAGATCTTCGGGCCTGTGCTG
CCCATCGTGTGCGTGCGCAGCCTGGAGGAGGCCATCCAGTTCATCAACCAGCGTGAGAAG
CCCCTGGCCCTCTACATGTTCTCCAGCAACGACAAGGTGATTAAGAAGATGATTGCAGAG
ACATCCAGTGGTGGGGTGGCGGCCAACGATGTCATCGTCCACATCACCTTGCACTCTCTG
CCCTTCGGGGGCGTGGGGAACAGCGGCATGGGATCCTACCATGGCAAGAAGAGCTTCGAG
ACTTTCTCTCACCGCCGCTCTTGCCTGGTGAGGCCTCTGATGAATGATGAAGGCCTGAAG
GTCAGATACCCCCCGAGCCCGGCCAAGATGACCCAGCACTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M74542

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_2_Locus:
17p11.2

# Metabolic_Enzyme_2_SNPs:
rs887241; rs2228100; rs3744692; rs2072330; rs4646787; rs1042183; rs917520; rs4646789; rs4646788; rs3786036; rs887240; rs2072329; rs4646790; rs3744693; rs9895030; rs3826507; rs3744695; rs3744694; rs2072328; rs1006556; rs4319825; rs1042172; rs11554977; rs11554978; rs11554975; rs11554974; rs34474118; rs3786037; rs35473971; rs4646792; rs35116940; rs4646791; rs35853488; rs887239; rs28531080; rs7216299; rs35009373; rs3786035; rs11385990; rs35308039; rs35128135; rs35885485; rs28552545; rs34438543; rs1006553; rs11650088; rs11651480; rs11870332; rs12948881; rs12949049; rs12951039; rs16960382; rs16960386; rs17793620; rs1989379; rs2016823; rs2052052; rs2072327; rs2108967; rs3760485; rs3760486; rs3760487; rs4646783; rs4646784; rs4646785; rs4646786; rs4924793; rs4925046; rs7214841; rs7221211; rs7225305; rs8075157; rs9898715; rs9900430

# Metabolic_Enzyme_2_General_References:
1737758; 8493892; 2037078; 9250352

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5358

# Metabolic_Enzyme_3_Name:
Aldehyde oxidase

# Metabolic_Enzyme_3_Synonyms:
Not Available

# Metabolic_Enzyme_3_Gene_Name:
AOX1

# Metabolic_Enzyme_3_Protein_Sequence:
>Aldehyde oxidase
MDRASELLFYVNGRKVIEKNVDPETMLLPYLRKKLRLTGTPYGCGGGGCGACTVMISRYN
PITKRIRHHPANACLIPICSLYGAAVTTVEGIGSTHTRIHPVQERIAKCHGTQCGFCTPG
MVMSIYPLLRNHPEPTLDQLTDALGGNLCRCHGYRPIIDACKTFCKTSGCCQSKENGVCC
LDQGINGLPEFEEGSKTSPKLFAEEEFLPLDPTQELIFPPELMIMADKQSQRTRVFGSER
MMWFSPVTLKDLLEFKFKYPQAPVIMGNTSVGPEVKFKGVFHPGYNSPDRIEEPECCKPC
IYGLTLGAGLSLAQVKDILADVVQKLPEEKTQMYHALLKHLGTLAGSQIRNMASLGGHII
SRHPDSDLNPILAVGNCTLNLLSKEGKRQIPLNEQFLSKCPNADLKPQEILVSVNIPISR
KWEFVSAFRQAQRQENALAIVNSGMRVFFGEGDGIIRELCISYGGVGPATICAKNSCQKL
IGRHWNEQMLDIACRLILNEVSLLGSAPGGKVEFKRTLIISFLFKFYLEVSQILKKMDPV
HYPSLADKYESALEDLHSKHHCSTLKYQNIGPKQHPEDPIGHPIMHLSGVKHATGEAIYC
DDMPLVDQELFLTFVTSSRAHAKIVSIDLSEALSMPGVVDIMTAEHLSDVNSFCFFTEAE
KFLATDKVFCVGQLVCAVLADSEVQAKRAAKRVKIVYQDLEPLILTIEESIQHNSSFKPE
RKLEYGNVDEAFKVVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDQEMDVYVSTQFPKY
IQDIVASTLKLPANKVMCHVRRVGGAFGGKVLKTGIIAAVTAFAANKHGRAVRCVLERGE
DMLITGGRHPYLGKYKAGFMNDGRILALDMEHYSNAGASLDESLFVIEMGLLKMDNAYKF
PNLRCRGWACRTNLPSNTAFRGFGFPQAVLITESCITEVAAKCGLSPEKVRIINMYKEID
QTPYKQEINAKNLIQCWRECMAMSSYSLRKVAVEKFNAENYWKKKGLAMVPLKFPVGLAS
RAAGQAAALVHIYLDGSVLVTHGGIEMGQGVHTKMIQVVSRELRMPMSNVHLRGTSTETV
PNANISGGSVVADLNGLAVKDACQTLLKRLEPIISKNPKGTWKDWAQTAFDESINLSAVG
YFRGYESDMNWEKGEGQPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGCSINPAID
IGQIEGAFIQGMGLYTIEELNYSPQGILHTRGPDQYKIPAICDMPTELHIALLPPSQNSN
TLYSSKGLGESGVFLGCSVFFAIHDAVSAARQERGLHGPLTLNSPLTPEKIRMACEDKFT
KMIPRDEPGSYVPWNVPI

# Metabolic_Enzyme_3_Number_of_Residues:
1338

# Metabolic_Enzyme_3_Molecular_Weight:
147933

# Metabolic_Enzyme_3_Theoretical_pI:
7.11

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  transporter activity
Function:  electron transporter activity
Function:  binding
Function:  ion binding
Function:  metal ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
An aldehyde + H(2)O + O(2) = a carboxylic acid + H(2)O(2)

# Metabolic_Enzyme_3_Pathway:
map00280  Valine, leucine and isoleucine degradation;
 map00350  Tyrosine metabolism;
 map00380  Tryptophan metabolism;
 map00750  Vitamin B6 metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_3_Reaction:
an aldehyde + H2O + O2 = a carboxylic acid + H2O2

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01315:Ald_Xan_dh_C;
PF02738:Ald_Xan_dh_C2;
PF03450:CO_deh_flav_C;
PF00941:FAD_binding_5;
PF00111:Fer2;
PF01799:Fer2_2

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.2.3.1

# Metabolic_Enzyme_3_GenBank_ID_Protein:
438656

# Metabolic_Enzyme_3_SwissProt_ID:
ADO_HUMAN (Q06278)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
AOX1

# Metabolic_Enzyme_3_Geneatlas_id:
AOX1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:553

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>4017 bp
ATGGACCGGGCGTCCGAGCTGCTCTTCTACGTGAACGGCCGCAAGGTGATAGAAAAAAAT
GTCGATCCTGAAACAATGCTGTTGCCTTATTTGAGGAAGAAGCTTCGACTCACAGGAACT
CCGTATGGCTGTGGAGGAGGAGGCTGTGGTGCTTGTACAGTGATGATATCACGATACAAC
CCCATCACCAAGAGGATAAGGCATCACCCAGCCAATGCCTGTCTGATTCCCATCTGTTCT
CTGTATGGTGCTGCCGTCACCACAGTAGAAGGCATAGGAAGCACCCACACCAGAATTCAT
CCTGTTCAGGAGAGGATTGCCAAGTGTCATGGCACCCAGTGTGGCTTCTGCACACCTGGG
ATGGTGATGTCCATCTACCCCCTGCTCAGGAACCACCCAGAGCCCACTCTGGATCAGTTA
ACTGATGCCCTTGGTGGTAACCTGTGCCGTTGCCATGGATACAGGCCCATAATTGATGCA
TGCAAGACTTTCTGTAAAACTTCGGGCTGCTGTCAAAGTAAAGAAAATGGGGTTTGCTGT
TTGGATCAAGGAATCAATGGATTGCCAGAATTTGAGGAAGGAAGTAAGACAAGTCCAAAA
CTCTTCGCAGAAGAGGAGTTTCTGCCATTGGATCCAACCCAGGAACTGATATTTCCTCCT
GAGCTAATGATAATGGCTGATAAACAGTCGCAAAGGACCAGGGTGTTTGGCAGTGAGAGA
ATGATGTGGTTTTCCCCCGTGACCCTGAAGGACCTGCTGGAATTTAAATTCAAGTATCCC
CAGGCTCCTGTTATCATGGGAAACACCTCTGTGGGGCCTGAAGTGAAATTTAAAGGCGTC
TTTCACCCAGGTTATAATTCTCCTGATAGAATTGAAGAACCTGAGTGTTGTAAACCATGC
ATATATGGACTCACCCTTGGTGCTGGTCTCAGCCTAGCCCAGGTGAAGGACATTTTGGCT
GATGTAGTCCAGAAGCTTCCAGAGGAGAAGACACAGATGTACCATGCTCTCCTGAAGCAT
TTGGGAACTCTGGCTGGGTCCCAGATCAGGAACATGGCTTCTTTAGGGGGACACATCATT
AGCAGGCATCCAGATTCAGATCTGAATCCCATCCTGGCTGTGGGTAACTGTACCCTCAAC
TTGCTATCAAAAGAAGGAAAACGACAGATTCCTTTAAATGAGCAATTCCTCAGCAAGTGC
CCTAATGCAGATCTTAAGCCTCAAGAAATCTTGGTCTCAGTGAACATCCCCATCTCAAGG
AAGTGGGAATTTGTGTCAGCCTTCCGACAAGCCCAGCGACAGGAGAATGCGCTAGCGATA
GTCAATTCAGGAATGAGAGTCTTTTTTGGAGAAGGGGATGGCATTATTAGAGAGTTATGC
ATCTCATATGGAGGCGTTGGTCCAGCCACCATCTGTGCCAAGAATTCCTGCCAGAAACTC
ATTGGAAGGCACTGGAACGAACAGATGCTGGATATAGCCTGCAGGCTTATTCTGAATGAA
GTCTCCCTTTTGGGCTCGGCGCCAGGTGGGAAAGTGGAGTTCAAGAGGACTCTCATCATC
AGCTTCCTCTTCAAGTTCTACCTGGAAGTGTCACAGATTTTGAAAAAGATGGATCCAGTT
CACTATCCTAGCCTTGCAGACAAGTATGAAAGTGCTTTAGAAGATCTTCATTCCAAACAT
CACTGCAGTACATTAAAGTACCAGAATATAGGCCCAAAGCAGCATCCTGAAGACCCAATT
GGCCACCCCATCATGCATCTGTCTGGTGTGAAGCATGCCACGGGGGAGGCCATCTACTGT
GATGACATGCCTCTGGTGGACCAGGAACTTTTCTTGACTTTTGTGACTAGTTCAAGAGCT
CATGCTAAGATTGTGTCTATTGATCTGTCAGAAGCTCTCAGCATGCCCGGTGTGGTGGAC
ATCATGACAGCAGAACATCTTAGTGACGTCAACTCCTTCTGCTTTTTTACTGAAGCTGAG
AAATTTCTGGCGACAGATAAGGTGTTCTGTGTGGGTCAGCTTGTCTGTGCTGTGCTTGCC
GATTCTGAGGTTCAGGCAAAGCGAGCTGCTAAGCGAGTGAAGATTGTCTATCAAGACTTG
GAGCCGCTGATACTAACAATTGAGGAAAGTATACAACACAACTCCTCCTTCAAGCCAGAA
AGGAAACTGGAATATGGAAATGTTGACGAAGCATTTAAAGTGGTTGATCAAATTCTTGAA
GGTGAAATACATATGGGAGGTCAAGAACATTTTTATATGGAAACCCAAAGCATGCTTGTC
GTTCCCAAGGGAGAGGATCAAGAAATGGATGTCTACGTGTCCACACAGTTTCCCAAATAT
ATACAGGACATTGTTGCCTCAACCTTGAAGCTCCCAGCTAACAAGGTCATGTGCCATGTA
AGGCGTGTTGGTGGAGCGTTTGGAGGGAAGGTGTTAAAAACCGGAATCATTGCAGCCGTC
ACTGCATTTGCCGCAAACAAACATGGCCGTGCAGTTCGCTGTGTTCTGGAACGAGGAGAA
GACATGTTAATAACTGGAGGCCGCCATCCTTACCTTGGAAAGTACAAAGCTGGATTCATG
AACGATGGCAGAATCTTGGCCCTGGACATGGAGCATTACAGCAATGCAGGCGCCTCCTTG
GATGAATCATTATTCGTGATAGAAATGGGACTTCTGAAAATGGACAATGCTTACAAGTTT
CCCAATCTCCGCTGCCGGGGTTGGGCATGCAGAACCAACCTTCCATCCAACACAGCTTTT
CGTGGGTTTGGCTTTCCTCAGGCAGTGCTGATCACCGAATCTTGTATCACGGAAGTTGCA
GCCAAATGTGGACTATCCCCTGAGAAGGTGCGAATCATAAACATGTACAAGGAAATTGAT
CAAACACCCTACAAACAAGAGATCAATGCCAAGAACCTAATCCAGTGTTGGAGAGAATGT
ATGGCCATGTCTTCCTACTCCTTGAGGAAAGTTGCTGTGGAAAAGTTCAATGCAGAGAAT
TATTGGAAGAAGAAAGGACTGGCCATGGTCCCCCTGAAGTTTCCTGTTGGCCTTGCGTCA
CGTGCTGCTGGTCAGGCTGCTGCCTTGGTTCACATTTATCTTGATGGCTCTGTGCTGGTC
ACTCACGGTGGAATTGAAATGGGGCAGGGGGTCCACACTAAAATGATTCAGGTGGTCAGC
CGTGAATTAAGAATGCCAATGTCGAATGTCCACCTGCGTGGAACAAGCACAGAAACTGTC
CCTAATGCAAATATCTCTGGAGGTTCTGTGGTGGCAGATCTCAACGGTTTGGCAGTAAAG
GATGCCTGTCAAACTCTTCTAAAACGCCTCGAACCCATCATCAGCAAGAATCCTAAAGGA
ACTTGGAAAGACTGGGCACAGACTGCTTTTGATGAAAGCATTAACCTTTCAGCTGTTGGA
TACTTCAGAGGTTATGAGTCAGACATGAACTGGGAGAAAGGCGAAGGCCAGCCCTTCGAA
TACTTTGTTTATGGAGCTGCCTGTTCCGAGGTTGAAATAGACTGCCTGACGGGGGATCAT
AAGAACATCAGAACAGACATTGTCATGGATGTTGGCTGCAGTATAAATCCAGCCATTGAC
ATAGGCCAGATTGAAGGTGCATTTATTCAAGGCATGGGACTTTATACAATAGAGGAACTG
AATTATTCTCCCCAGGGCATTCTGCACACTCGTGGTCCAGACCAATATAAAATCCCTGCC
ATCTGTGACATGCCCACGGAGTTGCACATTGCTTTGTTGCCTCCTTCTCAAAACTCAAAT
ACTCTTTATTCATCTAAGGGTCTGGGAGAGTCGGGGGTGTTCCTGGGGTGTTCCGTGTTT
TTCGCTATCCATGACGCAGTGAGTGCAGCACGACAGGAGAGAGGCCTGCATGGACCCTTG
ACCCTTAATAGTCCACTGACCCCGGAGAAGATTAGGATGGCCTGTGAAGACAAGTTCACA
AAAATGATTCCGAGAGATGAACCTGGATCCTACGTTCCTTGGAATGTACCCATCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
L11005

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_3_Locus:
2q33

# Metabolic_Enzyme_3_SNPs:
rs41309768; rs3731722; rs2540065; rs1050887; rs1050884; rs2465665; rs2470900; rs2002957; rs1405984; rs2348021; rs2463492; rs2287013; rs868810; rs2465663; rs1527948; rs1527944; rs2463488; rs2348023; rs2470899; rs2465657; rs2254576; rs1527947; rs2348020; rs6753383; rs6745304; rs3769832; rs1918720; rs6753463; rs1986415; rs2293529; rs2470897; rs2293526; rs6712290; rs1527945; rs4428003; rs4619591; rs9288313; rs4496322; rs2540069; rs3795968; rs6725945; rs2470902; rs6720189; rs7560168; rs2293527; rs7597590; rs2248130; rs4672865; rs10497866; rs13400369; rs2293524; rs2287012; rs3815502; rs3815503; rs2256977; rs4672866; rs2715905; rs7597713; rs12478624; rs4614918; rs2293525; rs2465661; rs7563522; rs2293528; rs7572503; rs7587871; rs4674311; rs7585422; rs10187029; rs6742109; rs12693921; rs2241080; rs13419464; rs4672863; rs16833921; rs17448359; rs6737912; rs2465662; rs2241079; rs6760616; rs4674247; rs7563294; rs10172572; rs7420798; rs4672858; rs12997909; rs6761840; rs4470327; rs11677071; rs1405985; rs6435060; rs6730068; rs3769833; rs17593811; rs6761375; rs2463489; rs1986414; rs2881811; rs17532777; rs2347864; rs17533238; rs2244004; rs11694112; rs4035120; rs10469649; rs17532875; rs10432435; rs2287008; rs2348024; rs11689822; rs11886414; rs12617551; rs6730363; rs16833889; rs10497853; rs17532973; rs7586707; rs2540067; rs1405986; rs12618843; rs2465664; rs12472360; rs4541241; rs2348025; rs17532798; rs17448345; rs10497865; rs13404701; rs11887334; rs13023526; rs12993621; rs2287010; rs3769835; rs12472146; rs13383127; rs2715904; rs2348026; rs10183589; rs12612264; rs4672890; rs2960198; rs17533140; rs6732225; rs4456685; rs2347866; rs12478294; rs10180210; rs10469650; rs10469754; rs7426150; rs11897036; rs17532861; rs10179330; rs16833885; rs17533070; rs6711025; rs6761252; rs10931910; rs10204846; rs2540068; rs10931908; rs1527946; rs2247553; rs10206891; rs17533245; rs17448443; rs13419468; rs4674302; rs4503970; rs2715910; rs2465658; rs6754573; rs4508579; rs17448796; rs12620550; rs17448686; rs12620549; rs4674211; rs12620402; rs2715908; rs2287011; rs1986390; rs2287007; rs7562507; rs3769834; rs6735253; rs17636860; rs10207809; rs16833843; rs7595235; rs17448457; rs13406379; rs2960199; rs4674303; rs7569193; rs2463490; rs12612263; rs10183184; rs6724797; rs2715907; rs10179964; rs7598198; rs4337457; rs2516310; rs2347865; rs3820973; rs10210831; rs2540066; rs17448366; rs2072034; rs12621063; rs2715906; rs16833793; rs35345784; rs35217482; rs35128788; rs34799295; rs13023698; rs35999824; rs13408225; rs16833923; rs1050883; rs34427902; rs1131360; rs1050880; rs35293679; rs34110600; rs2241078; rs2348022; rs36084232; rs34698837; rs34892292; rs2463491; rs2470898; rs35076002; rs34217541; rs41270243; rs2715912; rs4674312; rs34095667; rs13402885; rs34380410; rs17594160; rs34436757; rs35754442; rs35527063; rs11901126; rs10460401; rs2465656; rs10192757; rs2287009; rs10179743; rs34769434; rs34936215; rs11420110; rs35886858; rs4384770; rs35423095; rs34397235; rs35057419; rs6741421; rs35569511; rs34169163; rs35035526; rs34423504; rs36054632; rs17533098; rs12466511; rs34606301; rs12464348; rs2470901; rs4350730; rs16833848; rs34138997; rs34016786; rs13008443; rs34185958; rs6435057; rs4672864; rs34356762; rs17448436; rs34831618; rs35918797; rs13391622; rs35794546; rs6147125; rs13034124; rs35778058; rs2960200; rs10192320; rs13423540; rs6728850; rs12993144; rs6728655; rs3769831; rs10931909; rs35245400; rs34772975; rs12988162; rs10623702; rs35236730; rs11373771; rs34817848; rs35482569; rs13035983; rs34032166; rs35483227; rs35482626; rs10191685; rs4035251; rs5018931; rs34962228; rs35020940; rs35045512; rs13019825; rs34887452; rs13393615; rs41271445; rs35698374; rs4622702; rs35086177; rs11676316; rs34332493; rs35539595; rs4674202; rs6147126; rs9808414; rs10203810; rs10192066; rs2465659; rs11455886; rs34798357; rs11397147; rs4261701; rs34408231; rs34266344; rs35993423; rs34473107; rs34930734; rs3038607; rs34303220; rs13432214; rs13432700; rs34560359; rs1989739; rs2715911; rs41270241; rs35309776; rs35763564; rs35987427; rs11684094; rs13385678; rs34620856; rs5837752; rs4621154; rs34299045; rs34602028; rs34451961; rs10664948; rs6750300; rs34882667; rs34272316; rs35908613; rs36046548; rs13398115; rs11680797; rs34570620; rs4674197; rs11370694; rs12621852; rs11677893; rs11678615; rs11684227; rs11691962; rs12622081; rs13026134; rs13027665; rs13419425; rs16834021; rs16834027; rs16834034; rs2540064; rs4132842; rs4132843; rs4674194; rs6729738; rs7563682; rs7594798; rs7607141; rs878403

# Metabolic_Enzyme_3_General_References:
8248161

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5528

# Metabolic_Enzyme_4_Name:
Alpha-aminoadipic semialdehyde dehydrogenase

# Metabolic_Enzyme_4_Synonyms:
Alpha-AASA dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenease; P6c dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1

# Metabolic_Enzyme_4_Gene_Name:
ALDH7A1

# Metabolic_Enzyme_4_Protein_Sequence:
>Alphaaminoadipic semialdehyde dehydrogenase
MSTLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADY
EETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQ
EYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIA
MICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVN
LLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQ
RCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEA
KKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWN
NEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRES
GSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ

# Metabolic_Enzyme_4_Number_of_Residues:
511

# Metabolic_Enzyme_4_Molecular_Weight:
55367

# Metabolic_Enzyme_4_Theoretical_pI:
6.86

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H

# Metabolic_Enzyme_4_Pathway:
map00300  Lysine biosynthesis;
 map00310  Lysine degradation

# Metabolic_Enzyme_4_Reaction:
L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.2.1.31

# Metabolic_Enzyme_4_GenBank_ID_Protein:
797410

# Metabolic_Enzyme_4_SwissProt_ID:
AL7A1_HUMAN (P49419)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
ALDH7A1

# Metabolic_Enzyme_4_Geneatlas_id:
ALDH7A1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:877

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>1536 bp
ATGTCCACTCTCCTCATCAATCAGCCCCAGTATGCGTGGCTGAAAGAGCTGGGGCTCCGC
GAGGAAAACGAGGGCGTGTATAATGGAAGCTGGGGAGGCCGGGGAGAGGTTATTACGACC
TATTGCCCCGCTAACAACGAGCCAATAGCAAGAGTCCGACAGGCCAGTGTGGCAGACTAT
GAAGAAACTGTAAAGAAAGCAAGAGAAGCATGGAAAATCTGGGCAGATATTCCTGCTCCA
AAACGAGGAGAAATAGTAAGACAGATTGGCGATGCCTTGCGGGAGAAGATCCAAGTACTA
GGAAGCTTGGTGTCTTTGGAGATGGGGAAAATCTTAGTGGAAGGTGTGGGTGAAGTTCAG
GAGTATGTGGATATCTGTGACTATGCTGTTGGTTTATCAAGGATGATTGGAGGACCTATC
TTGCCTTCTGAAAGATCTGGCCATGCACTGATTGAGCAGTGGAATCCCGTAGGCCTGGTT
GGAATCATCACGGCATTCAATTTCCCTGTGGCAGTGTATGGTTGGAACAACGCCATCGCC
ATGATCTGTGGAAATGTCTGCCTCTGGAAAGGAGCTCCAACCACTTCCCTCATTAGTGTG
GCTGTCACAAAGATAATAGCCAAGGTTCTGGAGGACAACAAGCTGCCTGGTGCAATTTGT
TCCTTGACTTGTGGTGGAGCAGATATTGGCACAGCAATGGCCAAAGATGAACGAGTGAAC
CTGCTGTCCTTCACTGGGAGCACTCAGGTGGGAAAACAGGTGGGCCTGATGGTGCAGGAG
AGGTTTGGGAGAAGTCTGTTGGAACTTGGAGGAAACAATGCCATTATTGCCTTTGAAGAT
GCAGACCTCAGCTTAGTTGTTCCATCAGCTCTCTTCGCTGCTGTGGGAACAGCTGGCCAG
AGGTGTACCACTGCGAGGCGACTGTTTATACATGAAAGCATCCATGATGAGGTTGTAAAC
AGACTTAAAAAGGCCTATGCACAGATCCGAGTTGGGAACCCATGGGACCCTAATGTTCTC
TATGGGCCACTCCACACCAAGCAGGCAGTGAGCATGTTTCTTGGAGCAGTGGAAGAAGCA
AAGAAAGAAGGTGGCACAGTGGTCTATGGGGGCAAGGTTATGGATCGCCCTGGAAATTAT
GTAGAACCGACAATTGTGACAGGTCTTGGCCACGATGCGTCCATTGCACACACAGAGACT
TTCGCTCCGATTCTCTATGTCTTTAAATTCAAGAATGAAGAAGAGGTCTTTGCATGGAAT
AATGAAGTAAAACAGGGACTTTCAAGTAGCATCTTTACCAAAGATCTGGGCAGAATCTTT
CGCTGGCTTGGACCTAAAGGATCAGACTGTGGCATTGTAAATGTCAACATTCCAACAAGT
GGGGCTGAGATTGGAGGTGCCTTTGGAGGAGAAAAGCACACTGGTGGTGGCAGGGAGTCT
GGCAGTGATGCCTGGAAACAGTACATGAGAAGGTCTACTTGTACTATCAACTACAGTAAA
GACCTTCCTCTGGCCCAAGGAATCAAGTTTCAGTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
S74728

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_4_Locus:
5q31

# Metabolic_Enzyme_4_SNPs:
rs12514417; rs2306618; rs2775; rs1038381; rs6595719; rs4835912; rs1038378; rs1038380; rs2306617; rs4379190; rs4836276; rs11241901; rs4240406; rs12513847; rs7709115; rs4836272; rs7713264; rs6870785; rs11241902; rs7714044; rs1038379; rs10050642; rs7723008; rs4836277; rs3734175; rs6898430; rs17154671; rs4626334; rs13182402; rs17154679; rs4835914; rs12653605; rs2306619; rs7719675; rs10478743; rs7700981; rs2035472; rs11241903; rs6861395; rs7724875; rs2291295; rs10519915; rs7719712; rs6898559; rs4626335; rs17154676; rs11952752; rs13179664; rs4835913; rs11742214; rs3734174; rs11742381; rs7736031; rs7737529; rs10478744; rs4836275; rs17154666; rs34241005; rs10043987; rs7718426; rs2013986; rs10067785; rs7719091; rs17165056; rs13188450; rs900645; rs7708281; rs7703958; rs7723494; rs10050872; rs7702811; rs13171814; rs6897789; rs13177576; rs7704283; rs4526102; rs11741551; rs10038571; rs4836273; rs3736174; rs3736171; rs1483780; rs900641; rs744722; rs900640; rs7718710; rs1060856; rs744720; rs17165061; rs744721; rs1807; rs6865317; rs6884473; rs7447092; rs3189320; rs1049217; rs1049211; rs11542969; rs1049214; rs11269202; rs6898845; rs35027610; rs35284915; rs34275373; rs35570062; rs34674137; rs28429591; rs7730016; rs4612066; rs36058537; rs2408702; rs11406545; rs1142071; rs13356526; rs35492150; rs34697893; rs10539406; rs34825424; rs7703752; rs12187161; rs34949719; rs36125577; rs36077292; rs7719949; rs35736560; rs34201518; rs33926729; rs34250591; rs13185811; rs34323751; rs34907915; rs28865092; rs35559498; rs35109136; rs10630162; rs4836274; rs34972014; rs13173864; rs7709981; rs6870070; rs2408703; rs35118533; rs10532390; rs34517958; rs34069611; rs10629966; rs7706009; rs34496788; rs34935903; rs35115612; rs13174679; rs10609859; rs34995966; rs34074703; rs36120385; rs34424711; rs34537297; rs7737783; rs35457522; rs35367836; rs36017518; rs17597559; rs7730933; rs33954485; rs35196030; rs35930104; rs34575294; rs10666972; rs10676689; rs35010266; rs34035179; rs28629815; rs7704352; rs35797169; rs10044223; rs35622239; rs35960414; rs34959052; rs35342756; rs13154789; rs4836278; rs35617751; rs34731336; rs12656014; rs34305021; rs34684581; rs5871220; rs11951146; rs35290920; rs13166319; rs2408633; rs11290126; rs34862437; rs35992646; rs35110442; rs10609860; rs11742868; rs6896807; rs17531712; rs34770295; rs3080835; rs11387172; rs7737256; rs34601459; rs9765047; rs1060857; rs3736172; rs11458774; rs1138001; rs7447380; rs5871218; rs1138005; rs34410568; rs3736173; rs35569843; rs744723; rs5871219; rs34450389; rs34135005; rs3830274; rs11750167; rs1384880; rs17154635; rs2035471; rs2128931; rs2306620; rs2306621; rs2306622; rs2408700; rs28365789; rs3734173; rs4240405; rs4597966; rs4835911; rs4836271; rs6882015; rs730870; rs7715516; rs7726892

# Metabolic_Enzyme_4_General_References:
8088832; 9417906

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5529

# Metabolic_Enzyme_5_Name:
Aldehyde dehydrogenase 1A3

# Metabolic_Enzyme_5_Synonyms:
Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3

# Metabolic_Enzyme_5_Gene_Name:
ALDH1A3

# Metabolic_Enzyme_5_Protein_Sequence:
>Aldehyde dehydrogenase 1A3
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI
CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM
DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW
NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV
GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE
CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK
QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL
KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF
KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP

# Metabolic_Enzyme_5_Number_of_Residues:
512

# Metabolic_Enzyme_5_Molecular_Weight:
56109

# Metabolic_Enzyme_5_Theoretical_pI:
7.29

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_5_Specific_Function:
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system

# Metabolic_Enzyme_5_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_5_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_5_GenBank_ID_Protein:
544482

# Metabolic_Enzyme_5_SwissProt_ID:
AL1A3_HUMAN (P47895)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ALDH1A3

# Metabolic_Enzyme_5_Geneatlas_id:
ALDH1A3

# Metabolic_Enzyme_5_hgnc_id:
HGNC:409

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1539 bp
ATGGCCACCGCTAACGGGGCCGTGGAAAACGGGCAGCCGGACGGGAAGCCGCCGGCCCTG
CCGCGCCCCATCCGCAACCTGGAGGTCAAGTTCACCAAGATATTTATCAACAATGAATGG
CACGAATCCAAGAGTGGGAAAAAGTTTGCTACATGTAACCCTTCAACTCGGGAGCAAATA
TGTGAAGTGGAAGAAGGAGATAAGCCCGACGTGGACAAGGCTGTGGAGGCTGCACAGGTT
GCCTTCCAGAGGGGCTCGCCATGGCGCCGGCTGGATGCCCTGAGTCGTGGGCGGCTGCTG
CACCAGCTGGCTGACCTGGTGGAGAGGGACCGCGCCACCTTGGCCGCCCTGGAGACGATG
GATACAGGGAAGCCATTTCTTCATGCTTTTTTCATCGACCTGGAGGGCTGTATTAGAACC
CTCAGATACTTTGCAGGGTGGGCAGACAAAATCCAGGGCAAGACCATCCCCACAGATGAC
AACGTCGTATGCTTCACCAGGCATGAGCCCATTGGTGTCTGTGGGGCCATCACTCCATGG
AACTTCCCCCTGCTGATGCTGGTGTGGAAGCTGGCACCCGCCCTCTGCTGTGGGAACACC
ATGGTCCTGAAGCCTGCGGAGCAGACACCTCTCACCGCCCTTTATCTCGGCTCTCTGATC
AAAGAGGCCGGGTTCCCTCCAGGAGTGGTGAACATTGTGCCAGGATTCGGGCCCACAGTG
GGAGCAGCAATTTCTTCTCACCCTCAGATCAACAAGATCGCCTTCACCGGCTCCACAGAG
GTTGGAAAACTGGTTAAAGAAGCTGCGTCCCGGAGCAATCTGAAGCGGGTGACGCTGGAG
CTGGGGGGGAAGAACCCCTGCATCGTGTGTGCGGACGCTGACTTGGACTTGGCAGTGGAG
TGTGCCCATCAGGGAGTGTTCTTCAACCAAGGCCAGTGTTGCACGGCAGCCTCCAGGGTG
TTCGTGGAGGAGCAGGTCTACTCTGAGTTTGTCAGGCGGAGCGTGGAGTATGCCAAGAAA
CGGCCCGTGGGAGACCCCTTCGATGTCAAAACAGAACAGGGGCCTCAGATTGATCAAAAG
CAGTTCGACAAAATCTTAGAGCTGATCGAGAGTGGGAAGAAGGAAGGGGCCAAGCTGGAA
TGCGGGGGCTCAGCCATGGAAGACAAGGGGCTCTTCATCAAACCCACTGTCTTCTCAGAA
GTCACAGACAACATGCGGATTGCCAAAGAGGAGATTTTCGGGCCAGTGCAACCAATACTG
AAGTTCAAAAGTATCGAAGAAGTGATAAAAAGAGCGAATAGCACCGACTATGGACTCACA
GCAGCCGTGTTCACAAAAAATCTCGACAAAGCCCTGAAGTTGGCTTCTGCCTTAGAGTCT
GGAACGGTCTGGATCAACTGCTACAACGCCCTCTATGCACAGGCTCCATTTGGTGGCTTT
AAAATGTCAGGAAATGGCAGAGAACTAGGTGAATACGCTTTGGCCGAATACACAGAAGTG
AAAACTGTCACCATCAAACTTGGCGACAAGAACCCCTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U07919

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_5_Locus:
15q26.3

# Metabolic_Enzyme_5_SNPs:
rs3803430; rs2229183; rs1130738; rs14226; rs3803424; rs7045; rs3803426; rs7182089; rs4646690; rs7161860; rs4246328; rs4646688; rs4646668; rs4646670; rs3803428; rs4646671; rs6598396; rs4646675; rs9944290; rs7181897; rs4646684; rs4246323; rs4246327; rs4246329; rs4646674; rs8039374; rs4646678; rs4646653; rs4646655; rs7182884; rs3809521; rs11854028; rs3825926; rs3803433; rs6598397; rs4646662; rs4646685; rs4646651; rs4646672; rs3922685; rs4646654; rs3902902; rs4646683; rs7176046; rs3803432; rs4246324; rs4646661; rs8030776; rs12903828; rs4646687; rs4646680; rs3825925; rs7178221; rs3803427; rs7170197; rs4246325; rs8023972; rs4646681; rs7167278; rs4246326; rs1886; rs4646649; rs12908902; rs7171776; rs3803429; rs12914598; rs4646669; rs4646650; rs3803434; rs4646660; rs4646682; rs3809524; rs3809523; rs3809526; rs7179268; rs1130737; rs3803431; rs1130768; rs34302490; rs28760343; rs35300460; rs1802602; rs1802604; rs4288979; rs3803425; rs1802603; rs4646663; rs28691047; rs28731371; rs34655770; rs35165034; rs28509297; rs10400871; rs35129664; rs12905372; rs28405557; rs34486175; rs28546254; rs35055541; rs4646686; rs28441320; rs28410143; rs4646676; rs4646648; rs8029933; rs12910188; rs34182689; rs28504296; rs28449981; rs28507582; rs3825927; rs35310246; rs12910025; rs28384196; rs4343265; rs12910662; rs8028283; rs28475530; rs4392045; rs28369514; rs28377287; rs8035722; rs28480133; rs28707102; rs28583888; rs4646666; rs7173413; rs28472416; rs28673034; rs28668881; rs28711429; rs34837038; rs4646659; rs28452487; rs28712665; rs12910029; rs12902704; rs4646673; rs28689536; rs28431101; rs34431941; rs7178645; rs28454526; rs7170202; rs1889; rs4646647; rs4375646; rs11348272; rs4646656; rs28408085; rs28699556; rs28615197; rs28539744; rs28557216; rs28631565; rs34302839; rs3923499; rs4646664; rs35740226; rs28385499; rs3922686; rs28474807; rs28490217; rs12909825; rs10593974; rs28679806; rs28610999; rs7178553; rs35519561; rs35831758; rs35526807; rs4646658; rs28538652; rs28685242; rs10400842; rs4646667; rs35948146; rs4646677; rs7165217; rs10400872; rs28750207; rs3825924; rs7171453; rs34906846; rs4646665; rs9920154; rs36081993; rs11435500; rs28464660; rs4646679; rs12595234; rs4646689; rs3809522; rs35950557; rs3809527; rs7172149; rs7178931; rs8034153; rs7183889; rs3809525; rs4646646; rs11630601; rs11630691; rs11632820; rs11637204; rs11854709; rs12148466; rs12148493; rs12440023; rs12593839; rs12901792; rs12907776; rs12908105; rs12909230; rs12909791; rs28507591; rs3803435; rs4346184; rs4646694; rs7163108; rs7164136; rs7181644; rs8034686; rs8035036

# Metabolic_Enzyme_5_General_References:
7698756

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5530

# Metabolic_Enzyme_6_Name:
Aldehyde dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_6_Synonyms:
ALDH class 2; ALDHI; ALDH-E2

# Metabolic_Enzyme_6_Gene_Name:
ALDH2

# Metabolic_Enzyme_6_Protein_Sequence:
>Aldehyde dehydrogenase, mitochondrial precursor
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS

# Metabolic_Enzyme_6_Number_of_Residues:
517

# Metabolic_Enzyme_6_Molecular_Weight:
56382

# Metabolic_Enzyme_6_Theoretical_pI:
7.05

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_6_Specific_Function:
An aldehyde + NAD(+) + H(2)O = an acid + NADH

# Metabolic_Enzyme_6_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_6_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_6_Signals:
1-24

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_6_GenBank_ID_Protein:
28606

# Metabolic_Enzyme_6_SwissProt_ID:
ALDH2_HUMAN (P05091)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ALDH2

# Metabolic_Enzyme_6_Geneatlas_id:
ALDH2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:404

# Metabolic_Enzyme_6_PDB_ID:
1OF7

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_6_Gene_Sequence:
>1551 bp
ATGTTGCGCGCTGCCGCCGCTCGGGCCCCGCCTGGCCGCCGCCTCTTGTCAGCCGCCGCC
ACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTTCATA
AACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACT
GGAGAGGTCATCTGTCAGGTAGCTGAAGGGGACAAGGAAGATGTGGACAAGGCACGTGAA
GGCCGCCCGGGCGCCTTCCAGCTGGGCTCACCTTGGCGCCGCATGGACGCATCACACAGC
GGCCGGCTGCTGAACCGCCTGGCCGATCTGATCGAGCGGGACCGGACCTACCTGGCGGCC
TTGGAGACCCTGGACAATGGCAAGCCCTATGTCATCTCCTACCTGGTGGATTTGGACATG
GTCCTCAAATGTCTCCGGTATTATGCCGGCTGGGCTGATAAGTACCACGGGAAAACCATC
CCCATTGACGGAGACTTCTTCAGCTACACACGCCATGAACCTGTGGGGGTGTGCGGGCAG
ATCATTCCGTGGAATTTCCCGCTCCTGATGCAAGCATGGAAGCTGGGCCCAGCCTTGGCA
ACTGGAAACGTGGTTGTGATGAAGGTAGCTGAGCAGACACCCCTCACCGCCCTCTATGTG
GCCAACCTGATCAAGGAGGCTGGCTTTCCCCCTGGTGTGGTCAACATTGTGCCTGGATTT
GGCCCCACGGCTGGGGCCGCCATTGCCTCCCATGAGGATGTGGACAAAGTGGCATTCACA
GGCTCCACTGAGATTGGCCGCGTAATCCAGGTTGCTGCTGGGAGCAGCAACCTCAAGAGA
GTGACCTTGGAGCTGGGGGGGAAGAGCCCCAACATCATCATGTCAGATGCCGATATGGAT
TGGGCCGTGGAACAGGCCCACTTCGCCCTGTTCTTCAACCAGGGCCAGTGCTGCTGTGCC
GGCTCCCGGACCTTCGTGCAGGAGGACATCTATGATGAGTTTGTGGTGCGGAGCGTTGCC
CGGGCCAAGTCTCGGGTGGTCGGGAACCCCTTTGATAGCAAGACCGAGCAGGGGCCGCAG
GTGGATGAAACTCAGTTTAAGAAGATCCTCGGCTACATCAACACGGGGAAGCAAGAGGGG
GCGAAGCTGCTGTGTGGTGGGGGCATTGCTGCTGACCGTGGTTACTTCATCCAGCCCACT
GTGTTTGGAGATGTGCAGGATGGCATGACCATCGCCAAGGAGGAGATCTTCGGGCCAGTG
ATGCAGATCCTGAAGTTCAAGACCATAGAGGAGGTTGTTGGGAGAGCCAACAATTCCACG
TACGGGCTGGCCGCAGCTGTCTTCACAAAGGATTTGGACAAGGCCAATTACCTGTCCCAG
GCCCTCCAGGCGGGCACTGTGTGGGTCAACTGCTATGATGTGTTTGGAGCCCAGTCACCC
TTTGGTGGCTACAAGATGTCGGGGAGTGGCCGGGAGTTGGGCGAGTACGGGCTGCAGGCA
TACACTGAAGTGAAAACTGTCACAGTCAAAGTGCCTCAGAAGAACTCATAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
X05409

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_6_Locus:
12q24.2

# Metabolic_Enzyme_6_SNPs:
rs671; rs1062136; rs6490301; rs886205; rs2238151; rs968529; rs7296651; rs441; rs4767939; rs10744777; rs4646778; rs4767944; rs10849970; rs2158029; rs4646776; rs7312055; rs7311852; rs2238152; rs4646777; rs2283354; rs10774637; rs4648328; rs10774638; rs11609628; rs11066028; rs4646779; rs16941669; rs440; rs7397491; rs11834780; rs16941667; rs4646775; rs11066029; rs35154896; rs11066024; rs2106696; rs11613231; rs2158028; rs4767035; rs13306166; rs34083959; rs7136890; rs13306164; rs1064933; rs34477327; rs34884061; rs28633753; rs11442381; rs11615695; rs11066023; rs35511855; rs35781311; rs13306163; rs7397456; rs35050853; rs35642129; rs12312867; rs12829533; rs11407827; rs34480430; rs12314397; rs35264878; rs12813835; rs12322000; rs34896918; rs35650885; rs7970477; rs11066025; rs13306167; rs11066027; rs12301347; rs11614684; rs35700215; rs35746295; rs34587287; rs13306165; rs35786282; rs11066022; rs7397469; rs11066030; rs10450717; rs35693865; rs11503169; rs35546929; rs33973376; rs34497874; rs12830829; rs35061167; rs11609093; rs36073646; rs34108639; rs12824249; rs11610258; rs35147079; rs11613713; rs11066026; rs7486832; rs12099590; rs3832868; rs34300515; rs35212101; rs7398472; rs35239056; rs35752199; rs5800933; rs11613351; rs5023470; rs34587619; rs4646781; rs4646780; rs11304348; rs12305979; rs4646782; rs10849969; rs10849971; rs11066032; rs14630; rs2339839; rs2339840; rs7133964; rs737280; rs739580; rs7974339; rs7978737; rs9971942

# Metabolic_Enzyme_6_General_References:
3582651; 3562250; 2838413; 4065146; 2987944; 4015823; 3610592; 3653404; 6582480; 8561277; 10631996

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5531

# Metabolic_Enzyme_7_Name:
Fatty aldehyde dehydrogenase

# Metabolic_Enzyme_7_Synonyms:
Aldehyde dehydrogenase, microsomal; Aldehyde dehydrogenase family 3 member A2; Aldehyde dehydrogenase 10

# Metabolic_Enzyme_7_Gene_Name:
ALDH3A2

# Metabolic_Enzyme_7_Protein_Sequence:
>Fatty aldehyde dehydrogenase
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE
VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ
PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH
IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT
CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI
AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA
LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS
HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV
KAEYY

# Metabolic_Enzyme_7_Number_of_Residues:
485

# Metabolic_Enzyme_7_Molecular_Weight:
54849

# Metabolic_Enzyme_7_Theoretical_pI:
7.99

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_7_Specific_Function:
Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length

# Metabolic_Enzyme_7_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_7_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
464-480

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_7_GenBank_ID_Protein:
1082036

# Metabolic_Enzyme_7_SwissProt_ID:
AL3A2_HUMAN (P51648)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
ALDH3A2

# Metabolic_Enzyme_7_Geneatlas_id:
ALDH3A2

# Metabolic_Enzyme_7_hgnc_id:
HGNC:403

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein; cytoplasmic side

# Metabolic_Enzyme_7_Gene_Sequence:
>1458 bp
ATGGAGCTCGAAGTCCGGCGGGTCCGACAGGCGTTCCTGTCCGGCCGGTCGCGACCTCTG
CGGTTTCGGCTGCAGCAGCTGGAGGCCCTGCGGAGGATGGTGCAGGAGCGCGAGAAGGAT
ATCCTGACGGCCATCGCCGCCGACCTGTGCAAGAGTGAATTCAATGTGTACAGTCAGGAA
GTCATTACTGTCCTTGGGGAAATTGATTTTATGCTTGAGAATCTTCCTGAATGGGTTACT
GCTAAACCAGTTAAGAAGAACGTGCTCACCATGCTGGATGAGGCCTATATTCAGCCACAG
CCTCTGGGAGTGGTGCTGATAATCGGAGCTTGGAATTACCCCTTCGTTCTCACCATTCAG
CCACTGATAGGAGCCATCGCTGCAGGAAATGCTGTGATTATAAAGCCTTCTGAACTGAGT
GAAAATACAGCCAAGATCTTGGCAAAGCTTCTCCCTCAGTATTTAGACCAGGATCTCTAT
ATTGTTATTAATGGTGGTGTTGAGGAAACCACGGAGCTCCTGAAGCAGCGATTTGACCAC
ATTTTCTATACGGGAAACACTGCGGTTGGCAAAATTGTCATGGAAGCTGCTGCCAAGCAT
CTGACCCCTGTGACTCTTGAACTGGGAGGGAAAAGTCCATGTTATATTGATAAAGATTGT
GACCTGGACATTGTTTGCAGACGCATAACCTGGGGAAAATACATGAATTGTGGCCAAACC
TGCATTGCACCCGACTATATTCTCTGTGAAGCATCCCTCCAAAATCAAATTGTATGGAAG
ATTAAGGAAACAGTGAAGGAATTTTATGGAGAAAATATAAAAGAGTCTCCTGATTATGAA
AGGATCATCAATCTTCGTCATTTTAAGAGGATACTAAGTTTGCTTGAAGGACAAAAGATA
GCTTTTGGTGGGGAGACTGATGAGGCCACACGCTACATAGCCCCAACAGTACTTACCGAT
GTTGATCCTAAAACCAAGGTGATGCAAGAAGAAATTTTTGGACCAATTCTTCCAATAGTG
CCTGTGAAAAATGTAGATGAGGCCATAAATTTCATAAATGAACGTGAAAAGCCTCTGGCT
CTTTATGTATTTTCGCATAACCATAAGCTCATCAAACGGATGATTGATGAGACATCCAGT
GGAGGTGTCACAGGCAATGACGTCATTATGCACTTCACGCTCAACTCTTTCCCATTTGGA
GGAGTGGGTTCCAGTGGGATGGGAGCTTATCACGGAAAACATAGTTTTGATACTTTTTCT
CATCAGCGTCCCTGTTTATTAAAAAGTTTAAAGAGAGAAGGTGCTAACAAACTCAGATAT
CCTCCCAACAGCCAGTCAAAGGTGGATTGGGGGAAATTTTTTCTCTTGAAACGGTTCAAC
AAAGAAAAACTCGGTCTCCTGTTGCTCACTTTCCTGGGTATTGTAGCCGCTGTGCTTGTC
AAGGCAGAATATTACTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
L47162

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_7_Locus:
17p11.2

# Metabolic_Enzyme_7_SNPs:
rs7216; rs7503517; rs7215; rs16420; rs11204408; rs3786038; rs962801; rs2072333; rs1034897; rs2072331; rs2108971; rs1004490; rs1004491; rs4244600; rs962800; rs8069576; rs4925036; rs2072332; rs16960280; rs4646797; rs8069478; rs2386145; rs1800869; rs11204407; rs4646798; rs4646794; rs4925038; rs4646800; rs4925037; rs4646795; rs4646804; rs4646802; rs8073767; rs12937946; rs9910300; rs4646801; rs9901895; rs1034896; rs3760489; rs4621031; rs3888642; rs1057405; rs11548343; rs12947169; rs34160909; rs35364675; rs7209322; rs35495378; rs12947168; rs12708; rs4646805; rs7215552; rs35965955; rs2386146; rs35716578; rs34082599; rs4646799; rs4646796; rs3034928; rs1800870; rs35581449; rs5819686; rs34567842; rs34350257; rs34642385; rs4646793; rs11652177; rs4646907; rs34471504; rs8073053; rs2386147; rs6146012; rs34945824; rs36031953; rs34327718; rs35797108; rs34664206; rs4646803; rs35265843; rs36025724; rs35053333; rs3841513; rs34368630; rs4646806; rs35604266; rs16960266; rs28375263; rs11868363; rs11871420; rs11871642; rs12937179; rs1804608; rs2386144; rs34399035; rs34416664; rs35526408; rs4646807; rs4925026; rs8065688; rs8074204; rs8074500

# Metabolic_Enzyme_7_General_References:
8528251; 9027499; 9070922; 9254849; 9829906

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5532

# Metabolic_Enzyme_8_Name:
Aldehyde dehydrogenase X, mitochondrial precursor

# Metabolic_Enzyme_8_Synonyms:
Aldehyde dehydrogenase family 1 member B1; ALDH class 2

# Metabolic_Enzyme_8_Gene_Name:
ALDH1B1

# Metabolic_Enzyme_8_Protein_Sequence:
>Aldehyde dehydrogenase X, mitochondrial precursor
MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT
TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNLLADLVERDRVYLA
SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCG
QIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITG
YGPTAGAAIAQHMDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADM
EHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGP
QVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP
VQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHT
PFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS

# Metabolic_Enzyme_8_Number_of_Residues:
517

# Metabolic_Enzyme_8_Molecular_Weight:
57239

# Metabolic_Enzyme_8_Theoretical_pI:
6.79

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_8_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation

# Metabolic_Enzyme_8_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_8_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_8_Signals:
1-22

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_8_GenBank_ID_Protein:
1263008

# Metabolic_Enzyme_8_SwissProt_ID:
AL1B1_HUMAN (P30837)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
ALDH1B1

# Metabolic_Enzyme_8_Geneatlas_id:
ALDH1B1

# Metabolic_Enzyme_8_hgnc_id:
HGNC:407

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_8_Gene_Sequence:
>1554 bp
ATGCTGCGCTTCCTGGCACCCCGGCTGCTTAGCCTCCAGGGCAGGACCGCCCTCTACTCC
TCGGCAGCAGCCCTCCCAAGCCCCATTCTGAACCCAGACATCCCCTACAACCAGCTGTTC
ATCAACAATGAATGGCAAGATGCAGTCAGCAAGAAGACCTTCCCGACGGTCAACCCTACC
ACCGGGGAGGTCATCGGGCACGTGGCTGAAGGTGACCGGGCTGATGTGGATCGGGCCGTG
AAAGCAGCCCGGGAAGCCTTCCGCCTGGGGTCCCCATGGCGCCGGATGGATGCCTCTGAG
CGGGGCCGGCTGCTGAACCTCCTGGCAGACCTAGTGGAGCGGGATCGAGTCTACTTGGCC
TCACTCGAGACCTTGGACAATGGGAAGCCTTTCCAAGAGTCTTACGCCTTGGACTTGGAT
GAGGTCATCAAGGTGTATCGGTACTTTGCTGGCTGGGCTGACAAGTGGCATGGCAAGACC
ATCCCCATGCATGGCCAGCATTTCTGCTTCACCCGGCATGAGCCCGTTGGTGTCTGTGGC
CAGATCATCCCGTGGAACTTCCCCTTGGTCATGCAGGGTTGGAAACTTGCCCCGGCACTC
GCCACAGGCAACACTGTGGTTATGAAGGTGGCAGAGCAGACCCCCCTCTCTGCCCTGTAT
TTGGCCTCCCTCATCAAGGAGGCAGGCTTTCCCCCTGGGGTGGTGAACATCATCACGGGG
TATGGCCCAACAGCAGGTGCGGCCATCGCCCAGCACATGGATGTTGACAAAGTTGCCTTC
ACCGGTTCCACCGAGGTGGGCCACCTGATCCAGAAAGCAGCTGGCGATTCCAACCTCAAG
AGAGTCACCCTGGAGCTGGGTGGTAAGAGCCCCAGCATCGTGCTGGCCGATGCTGACATG
GAGCATGCCGTGGAGCAGTGCCACGAAGCCCTGTTCTTCAACATGGGCCAGTGCTGCTGT
GCTGGCTCCCGGACCTTCGTGGAAGAATCCATCTACAATGAGTTTCTCGAGAGAACCGTG
GAGAAAGCAAAGCAGAGGAAAGTGGGGAACCCCTTTGAGCTGGACACCCAGCAGGGGCCT
CAGGTGGACAAGGAGCAGTTTGAACGAGTCCTAGGCTACATCCAGCTTGGCCAGAAGGAG
GGCGCAAAACTCCTCTGTGGCGGAGAGCGTTTCGGGGAGCGTGGTTTCTTCATCAAGCCT
ACTGTCTTTGGTGGCGTGCAGGATGACATGAGAATTGCCAAAGAGGAGATCTTTGGGCCT
GTGCAGCCCCTGTTCAAGTTCAAGAAGATTGAGGAGGTGGTTGAGAGGGCCAACAACACC
AGGTATGGCCTGGCTGCGGCTGTGTTCACCCGGGATCTGGACAAGGCCATGTACTTCACC
CAGGCACTCCAGGCCGGGACCGTGTGGGTAAACACCTACAACATCGTCACCTGCCACACG
CCATTTGGAGGGTTTAAGGAATCTGGAAACGGGAGGGAGCTGGGTGAGGATGGGCTTAAG
GCCTACACAGAGGTAAAGACGGTCACCATCAAGGTTCCTCAGAAGAACTCGTAA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
M63967

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_8_Locus:
9p11.1

# Metabolic_Enzyme_8_SNPs:
rs2228093; rs4878199; rs2073478; rs2073477; rs2228094; rs3043; rs6476701; rs10758494; rs10758495; rs7859877; rs4646772; rs4646774; rs4878802; rs10738997; rs11555705; rs4646773; rs41278335; rs11555706; rs10973781; rs10973782; rs12343271; rs41278337; rs10118683; rs10758496; rs10814687; rs10973774; rs10973779; rs10973783; rs10973785; rs10973786; rs10973787; rs10973789; rs10973792; rs11361; rs11790480; rs11791018; rs11791622; rs12001093; rs12336048; rs12352007; rs12378762; rs13285234; rs13290293; rs1555480; rs1923423; rs1923424; rs2038589; rs34183602; rs35950473; rs4142260; rs4242647; rs4878203; rs4878800; rs4878801; rs4878804; rs4878805; rs4878806; rs4878807; rs4878808; rs4878809; rs4878811; rs6476703; rs7021469; rs7031628; rs7045542; rs7046137; rs7853954; rs7865905; rs7866277; rs7867383; rs911757; rs911758

# Metabolic_Enzyme_8_General_References:
2061311; 8244338

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5489

# Metabolic_Enzyme_9_Name:
Methylmalonyl-CoA mutase, mitochondrial precursor

# Metabolic_Enzyme_9_Synonyms:
MCM; Methylmalonyl-CoA isomerase

# Metabolic_Enzyme_9_Gene_Name:
MUT

# Metabolic_Enzyme_9_Protein_Sequence:
>MethylmalonylCoA mutase, mitochondrial precursor
MLRAKNQLFLLSPHYLRQVKESSGSRLIQQRLLHQQQPLHPEWAALAKKQLKGKNPEDLI
WHTPEGISIK
PLYSKRDTMDLPEELPGVKPFTRGPYPTMYTFRPWTIRQYAGFSTVEES
NKFYKDNIKAGQQGLSVAFDL
ATHRGYDSDNPRVRGDVGMAGVAIDTVEDTKILFDGIP
LEKMSVSMTMNGAVIPVLANFIVTGEEQGVPK
EKLTGTIQNDILKEFMVRNTYIFPPEP
SMKIIADIFEYTAKHMPKFNSISISGYHMQEAGADAILELAYT
LADGLEYSRTGLQAGL
TIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFQPKNSKSLLLRAH
CQTSG
WSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGLPTVKSARIARNTQIIIQEE
SGIPK
VADPWGGSYMMECLTNDVYDAALKLINEIEEMGGMAKAVAEGIPKLRIEECAAR
RQARIDSGSEVIVGVN
KYQLEKEDAVEVLAIDNTSVRNRQIEKLKKIKSSRDQALAERC
LAALTECAASGDGNILALAVDASRARC
TVGEITDALKKVFGEHKANDRMVSGAYRQEFG
ESKEITSAIKRVHKFMEREGRRPRLLVAKMGQDGHDRG
AKVIATGFADLGFDVDIGPLF
QTPREVAQQAVDADVHAVGVSTLAAGHKTLVPELIKELNSLGRPDILVM
CGGVIPPQDY
EFLFEVGVSNVFGPGTRIPKAAVQVLDDIEKCLEKKQQSV

# Metabolic_Enzyme_9_Number_of_Residues:
750

# Metabolic_Enzyme_9_Molecular_Weight:
83121

# Metabolic_Enzyme_9_Theoretical_pI:
6.92

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  intramolecular transferase activity
Function:  methylmalonyl-CoA mutase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  cobalt ion binding
Function:  catalytic activity
Function:  isomerase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
Involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species

# Metabolic_Enzyme_9_Pathway:
map00280  Valine, leucine and isoleucine degradation;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_9_Reaction:
(R)-methylmalonyl-CoA = succinyl-CoA

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF02310:B12-binding;
PF01642:MM_CoA_mutase

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 5.4.99.2

# Metabolic_Enzyme_9_GenBank_ID_Protein:
187452

# Metabolic_Enzyme_9_SwissProt_ID:
MUTA_HUMAN (P22033)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
MUT

# Metabolic_Enzyme_9_Geneatlas_id:
MUT

# Metabolic_Enzyme_9_hgnc_id:
HGNC:7526

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_9_Gene_Sequence:
>2253 bp

ATGTTAAGAGCTAAGAATCAGCTTTTTTTACTTTCACCTCATTACCTGAGGCAGGTAAA
AGAATCATCAG
GCTCCAGGCTCATACAGCAACGACTTCTACACCAGCAACAGCCCCTTC
ACCCAGAATGGGCTGCCCTGGC
TAAAAAGCAGCTGAAAGGCAAAAACCCAGAAGACCTA
ATATGGCACACCCCGGAAGGGATCTCTATAAAA
CCCTTGTATTCCAAGAGAGATACTAT
GGACTTACCTGAAGAACTTCCAGGAGTGAAGCCATTCACACGTG
GACCATATCCTACCA
TGTATACCTTTAGGCCCTGGACCATCCGCCAGTATGCTGGTTTTAGTACTGTGGA
AGAA
AGCAATAAGTTCTATAAGGACAACATTAAGGCTGGTCAGCAGGGATTATCAGTTGCCTTT
GATCTG
GCGACACATCGTGGCTATGATTCAGACAACCCTCGAGTTCGTGGTGATGTTGG
AATGGCTGGAGTTGCTA
TTGACACTGTGGAAGATACCAAAATTCTTTTTGATGGAATTC
CTTTAGAAAAAATGTCAGTTTCCATGAC
TATGAATGGAGCAGTTATTCCAGTTCTTGCA
AATTTTATAGTAACTGGAGAAGAACAAGGTGTACCTAAA
GAGAAACTTACTGGTACCAT
CCAAAATGATATACTAAAGGAATTTATGGTTCGAAATACATACATTTTTC
CTCCAGAAC
CATCCATGAAAATTATTGCTGACATATTTGAATATACAGCAAAGCACATGCCAAAATTTA
A
TTCAATTTCAATTAGTGGATACCATATGCAGGAAGCAGGGGCTGATGCCATTCTGGAG
CTGGCCTATACT
TTAGCAGATGGATTGGAGTACTCTAGAACTGGACTCCAGGCTGGCCT
GACAATTGATGAATTTGCACCAA
GGTTGTCTTTCTTCTGGGGAATTGGAATGAATTTCT
ATATGGAAATAGCAAAGATGAGAGCTGGTAGAAG
ACTCTGGGCTCACTTAATAGAGAAA
ATGTTTCAGCCTAAAAACTCAAAATCTCTTCTTCTAAGAGCACAC
TGTCAGACATCTGG
ATGGTCACTTACTGAGCAGGATCCCTACAATAATATTGTCCGTACTGCAATAGAAG
CAA
TGGCAGCAGTATTTGGAGGGACTCAGTCTTTGCACACAAATTCTTTTGATGAAGCTTTGG
GTTTGCC
AACTGTGAAAAGTGCTCGAATTGCCAGGAACACACAAATCATCATTCAAGAA
GAATCTGGGATTCCCAAA
GTGGCTGATCCTTGGGGAGGTTCTTACATGATGGAATGTCT
CACAAATGATGTTTATGATGCTGCTTTAA
AGCTCATTAATGAAATTGAAGAAATGGGTG
GAATGGCCAAAGCTGTAGCTGAGGGAATACCTAAACTTCG
AATTGAAGAATGTGCTGCC
CGAAGACAAGCTAGAATAGATTCTGGTTCTGAAGTAATTGTTGGAGTAAAT
AAGTACCA
GTTGGAAAAAGAAGACGCTGTAGAAGTTCTGGCAATTGATAATACTTCAGTGCGAAACAG
GC
AGATTGAAAAACTTAAGAAGATCAAATCCAGCAGGGATCAAGCTTTGGCTGAACATT
GTCTTGCTGCACT
AACCGAATGTGCTGCTAGCGGAGATGGAAATATCCTGGCTCTTGCA
GTGGATGCATCTCGGGCAAGATGT
ACAGTGGGAGAAATCACAGATGCCCTGAAAAAGGT
ATTTGGTGAACATAAAGCGAATGATCGAATGGTGA
GTGGAGCATATCGCCAGGAATTTG
GAGAAAGTAAAGAGATAACATCTGCTATCAAGAGGGTTCATAAATT
CATGGAACGTGAA
GGTCGCAGACCTCGTCTTCTTGTAGCAAAAATGGGACAAGATGGCCATGACAGAGGA
GC
AAAAGTTATTGCTACAGGATTTGCTGATCTTGGTTTTGATGTGGACATAGGCCCTCTTTT
CCAGACTC
CTCGTGAAGTGGCCCAGCAGGCTGTGGATGCGGATGTGCATGCTGTGGGCG
TAAGCACCCTCGCTGCTGG
TCATAAAACCCTAGTTCCTGAACTCATCAAAGAACTTAAC
TCCCTTGGACGGCCAGATATTCTTGTCATG
TGTGGAGGGGTGATACCACCTCAGGATTA
TGAATTTCTGTTTGAAGTTGGTGTTTCCAATGTATTTGGTC
CTGGGACTCGAATTCCAA
AGGCTGCCGTTCAGGTGCTTGATGATATTGAGAAGTGTTTGGAAAAGAAGCA
GCAATCT
GTATAA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
M65131

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_9_Locus:
6p21

# Metabolic_Enzyme_9_SNPs:
Not Available

# Metabolic_Enzyme_9_General_References:
2567699; 1980486; 14574404; 7912889; 8990001; 1670635; 1977311; 1346616; 1351030; 7909321; 9452100; 9554742

# Metabolic_Enzyme_9_References:
10882753; 11237984; 11400752; 12402345

# Metabolic_Enzyme_10_ID:
6300

# Metabolic_Enzyme_10_Name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial precursor

# Metabolic_Enzyme_10_Synonyms:
Cob(Ialamin adenosyltransferase; Methylmalonic aciduria type B protein

# Metabolic_Enzyme_10_Gene_Name:
MMAB

# Metabolic_Enzyme_10_Protein_Sequence:
>CobIyrinic acid a,cdiamide adenosyltransferase, mitochondrial precursor
MAVCGLGSRLGLGSRLGLRGCFGAARLLYPRFQSRGPQGVEDGDRPQPSSKTPRIPKIYT
KTGDKGFSSTFTGERRPKDDQVFEAVGTTDELSSAIGFALELVTEKGHTFAEELQKIQCT
LQDVGSALATPCSSAREAHLKYTTFKAGPILELEQWIDKYTSQLPPLTAFILPSGGKISS
ALHFCRAVCRRAERRVVPLVQMGETDANVAKFLNRLSDYLFTLARYAAMKEGNQEKIYMK
NDPSAESEGL

# Metabolic_Enzyme_10_Number_of_Residues:
250

# Metabolic_Enzyme_10_Molecular_Weight:
27389

# Metabolic_Enzyme_10_Theoretical_pI:
8.78

# Metabolic_Enzyme_10_GO_Classification:
Not Available

# Metabolic_Enzyme_10_General_Function:
Not Available

# Metabolic_Enzyme_10_Specific_Function:
ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide

# Metabolic_Enzyme_10_Pathway:
map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_10_Reaction:
(1) ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide; (2) ATP + cobinamide = triphosphate + adenosylcobinamide

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF01923:Cob_adeno_trans

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.5.1.17

# Metabolic_Enzyme_10_GenBank_ID_Protein:
26284726

# Metabolic_Enzyme_10_SwissProt_ID:
MMAB_HUMAN (Q96EY8)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
MMAB

# Metabolic_Enzyme_10_Geneatlas_id:
MMAB

# Metabolic_Enzyme_10_hgnc_id:
HGNC:19331

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Mitochondrion (Probable)

# Metabolic_Enzyme_10_Gene_Sequence:
>753 bp
ATGGCTGTGTGCGGCCTGGGGAGCCGTCTTGGCCTGGGGAGCCGTCTTGGCCTGCGCGGG
TGCTTCGGCGCCGCCAGGCTCCTGTATCCCCGTTTCCAGAGCCGCGGCCCTCAGGGCGTG
GAAGACGGGGACAGGCCACAGCCTTCCTCGAAGACACCCAGGATCCCCAAGATTTACACC
AAAACGGGAGACAAAGGGTTTTCTAGTACCTTCACAGGAGAAAGGAGACCCAAAGATGAC
CAAGTGTTTGAAGCCGTGGGAACTACAGATGAATTAAGTTCAGCTATTGGGTTTGCTCTG
GAATTAGTCACAGAAAAGGGCCATACATTTGCCGAAGAGCTTCAGAAAATCCAGTGCACA
TTGCAGGACGTCGGCTCGGCCCTGGCGACACCATGCTCCTCGGCCCGGGAGGCTCACTTA
AAGTATACCACGTTCAAGGCGGGGCCCATCCTGGAGCTGGAGCAGTGGATCGACAAGTAC
ACCAGCCAGCTCCCACCACTCACGGCCTTCATCCTGCCTTCGGGAGGCAAGATCAGCTCG
GCGCTGCATTTCTGCCGGGCCGTGTGCCGCCGGGCCGAGAGACGTGTGGTGCCTCTTGTC
CAGATGGGAGAGACCGATGCGAACGTGGCCAAGTTCTTAAACAGACTCAGTGACTATCTC
TTCACGCTAGCCAGATATGCAGCCATGAAGGAGGGGAATCAAGAGAAAATATACATGAAA
AATGACCCATCGGCCGAGTCTGAGGGACTCTGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
AF550404

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_10_Locus:
12q24

# Metabolic_Enzyme_10_SNPs:
rs9593; rs35648932; rs877710; rs11831226; rs8228; rs11067231; rs877709; rs1061440; rs11067233; rs754179; rs4499061; rs7301541; rs7953014; rs754180; rs7134594; rs11067253; rs2058805; rs2287180; rs11610545; rs888192; rs736343; rs7964021; rs7970557; rs2058806; rs11836136; rs10850379; rs2287182; rs10850380; rs2287181; rs12580090; rs12309115; rs874171; rs9919738; rs874170; rs11067271; rs2287183; rs11614986; rs12828717; rs736344; rs11067250; rs12578365; rs2241201; rs35145546; rs11067227; rs10660207; rs11067232; rs1044600; rs35186764; rs35879276; rs10660206; rs34921355; rs12319408; rs3180951; rs10592425; rs34507867; rs34483852; rs7302373; rs35461814; rs35642604; rs34993195; rs35072126; rs888191; rs7312142; rs12370596; rs34899324; rs28505344; rs12822488; rs7302591; rs12830693; rs11067297; rs35906393; rs35868034; rs7971853; rs7294475; rs11614788; rs34860149; rs35107702; rs7312275; rs12817689; rs35443581; rs2241202; rs33964138; rs10665981; rs10623308; rs2241203; rs34266904; rs1075467; rs1075468; rs11067176; rs11067192; rs11067208; rs11067211; rs11067330; rs12306158; rs12314392; rs12321904; rs12813499; rs12828090; rs2287218; rs34368092; rs3752662; rs3759387; rs3782899; rs4766477; rs4766611; rs4766613; rs6606734; rs7300998; rs7954144; rs7957619; rs7974083; rs7974321; rs888193; rs888194

# Metabolic_Enzyme_10_General_References:
12514191

# Metabolic_Enzyme_10_References:
16410054

# Macromolecular_Interacting_Partner_1_ID:
7084

# Macromolecular_Interacting_Partner_1_Name:
Transcobalamin-2 precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Transcobalamin II; TCII; TC II

# Macromolecular_Interacting_Partner_1_Gene_Name:
TCN2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Transcobalamin2 precursor
MRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRL
SSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEFVR
GHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLL
YAVEPFHQGHHSVDTAAMAGLAFTCLKRSNFNPGRRQRITMAIRTVREEILKAQTPEGHF
GNVYSTPLALQFLMTSPMPGAELGTACLKARVALLASLQDGAFQNALMISQLLPVLNHKT
YIDLIFPDCLAPRVMLEPAAETIPQTQEIISVTLQVLSLLPPYRQSISVLAGSTVEDVLK
KAHELGGFTYETQASSSGPYLTSVMGKAAGEREFWQLLRDPNTPLLQGIADYRPKDGETI
ELRLVSW

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
427

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
47451

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.89

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01122:Cobalamin_bind

# Macromolecular_Interacting_Partner_1_Signals:
1-18

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
339196

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
TCO2_HUMAN (P20062)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
TCN2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
TCN2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:11653

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1284 bp
ATGAGGCACCTTGGGGCCTTCCTCTTCCTTCTGGGGGTCCTGGGGGCCCTCACTGAGATG
TGTGAAATACCAGAGATGGACAGCCATCTGGTAGAGAAGTTGGGCCAGCACCTCTTACCT
TGGATGGACCGGCTTTCCCTGGAGCACTTGAACCCCAGCATCTATGTGGGCCTACGCCTC
TCCAGTCTGCAGGCTGGGACCAAGGAAGACCTCTACCTGCACAGCCTCAAGCTTGGTTAC
CAGCAGTGCCTCCTAGGGTCTGCCTTCAGCGAGGATGACGGTGACTGCCAGGGCAAGCCT
TCCATGGGCCAGCTGGCCCTCTACCTGCTCGCTCTCAGAGCCAACTGTGAGTTTGTCAGG
GGCCACAAGGGGGACAGGCTGGTCTCACAGCTCAAATGGTTCCTGGAGGATGAGAAGAGA
GCCATTGGGCATGATCACAAGGGCCACCCCCACACTAGCTACTACCAGTATGGCCTGGGC
ATTCTGGCCCTGTGTCTCCACCAGAAGCGGGTCCATGACAGCGTGGTGGACAAACTTCTG
TATGCTGTGGAACCTTTCCACCAGGGCCACCATTCTGTGGACACAGCAGCCATGGCAGGC
TTGGCATTCACCTGTCTGAAGCGCTCAAACTTCAACCCTGGTCGGAGACAACGGATCACC
ATGGCCATCAGAACAGTGCGAGAGGAGATCTTGAAGGCCCAGACCCCCGAGGGCCACTTT
GGGAATGTCTACAGCACCCCATTGGCATTACAGTTCCTCATGACTTCCCCCATGCCTGGG
GCAGAACTGGGAACAGCATGTCTCAAGGCGAGGGTTGCTTTGCTGGCCAGTCTGCAGGAT
GGAGCCTTCCAGAATGCTCTCATGATTTCCCAGCTGCTGCCCGTTCTGAACCACAAGACC
TACATTGATCTGATCTTCCCAGACTGTCTGGCACCACGAGTCATGTTGGAACCAGCTGCT
GAGACCATTCCTCAGACCCAAGAGATCATCAGTGTCACGCTGCAGGTGCTTAGTCTCTTG
CCGCCGTACAGACAGTCCATCTCTGTTCTGGCCGGGTCCACCGTGGAAGATGTCCTGAAG
AAGGCCCATGAGTTAGGAGGATTCACATATGAAACACAGGCCTCCTCGTCAGGCCCCTAC
TTAACCTCCGTGATGGGGAAAGCGGCCGGAGAAAGGGAGTTCTGGCAGCTTCTCCGAGAC
CCCAACACCCCACTGTTGCAAGGTATTGCTGACTACAGACCCAAGGATGGAGAAACCATT
GAGCTGAGGCTGGTTAGCTGGTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M60396

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_1_Locus:
22q12.2

# Macromolecular_Interacting_Partner_1_SNPs:
rs9606756; rs4820889; rs1801198; rs9621049; rs35838082; rs35915865; rs10418; rs2072195; rs740234; rs4820021; rs9621047; rs2009857; rs5997704; rs7289549; rs5749134; rs4820888; rs5749132; rs5749135; rs4820882; rs5753236; rs2267163; rs2072194; rs4820886; rs9609019; rs8140674; rs2267162; rs8139921; rs2301955; rs13056378; rs740233; rs16988828; rs11703570; rs2301956; rs5997702; rs2267164; rs7286680; rs8141515; rs2283873; rs4820887; rs4820020; rs5997703; rs16988855; rs2301958; rs5753250; rs12160662; rs4820885; rs4375972; rs11912238; rs4820890; rs2267166; rs12159600; rs4820884; rs12485165; rs5753244; rs13058587; rs4820022; rs4820881; rs5753235; rs5753246; rs9609017; rs11703609; rs5753252; rs7290898; rs2009862; rs5753249; rs757874; rs16988838; rs2301957; rs5753247; rs4820880; rs11913239; rs10439913; rs740235; rs1544468; rs5753231; rs5749131; rs2240433; rs1971653; rs5753230; rs1131603; rs11557600; rs17849434; rs35997415; rs9609023; rs1032; rs12160073; rs34370289; rs12169610; rs5844915; rs13057795; rs7286107; rs12160900; rs35321301; rs11702958; rs3216412; rs35127123; rs5749136; rs34886169; rs2412993; rs35307566; rs12485216; rs10579068; rs35112726; rs34767507; rs3067250; rs11704077; rs13058607; rs10592011; rs5753234; rs11704076; rs5749137; rs10427979; rs5753241; rs5997707; rs35611144; rs5994324; rs9609018; rs3067251; rs36004774; rs12160098; rs9609022; rs12160394; rs5749138; rs12160944; rs5753248; rs11306636; rs34121103; rs4820883; rs2267165; rs9609021; rs13056885; rs12160748; rs13057506; rs34945468; rs5997706; rs35217811; rs34579658; rs34383530; rs12168392; rs5997701; rs5753232; rs11702925; rs7288385; rs13057622; rs5844914; rs34978834; rs13057151; rs11413765; rs7288627; rs13055009; rs34136060; rs35672212; rs28704032; rs13057127; rs35458286; rs5749133; rs13056240; rs10522175; rs9619126; rs5753233; rs9606757; rs35548717; rs28533163; rs12169435; rs13057679; rs36019407; rs11305698; rs34385490; rs35245021; rs13058138; rs35867527; rs34197514; rs34471369; rs16988823; rs11089465; rs12158552; rs12159171; rs13054505; rs13054912; rs3887855; rs4350856; rs4820023; rs4820891; rs5749141; rs5749142; rs5749143; rs5749144; rs5749148; rs5753224; rs5753227; rs5753259; rs5753260; rs5997710; rs5997711; rs5997712; rs7284161; rs7289553; rs731990; rs731991; rs8137501; rs9306264; rs9609024; rs9621051; rs9621053

# Macromolecular_Interacting_Partner_1_General_References:
1708393; 8439564; 7742531; 10591208; 3782074; 8443384; 11159542

# Macromolecular_Interacting_Partner_1_References:
12091374

End of HMDB00202

Beginning of HMDB00205
# Accession_No:
HMDB00205

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-30 10:18:59

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Phenylpyruvic acid

# Description:
If the enzyme which converts phenylalanine into tyrosine is missing, then phenylalanine undergoes a transamination reaction to make phenylpyruvic acid instead.  Phenylpyruvic acid can be found in the urine when excessive levels have built up. If untreated, mental retardation effects are evident by the first year along with other symptoms which include: unusual irritability, epileptic seizures and skin lesions. 

# Synonyms:
2-Oxo-3-phenylpropanoate; 2-Oxo-3-phenylpropanoic acid; 3-Phenyl-2-oxopropanoate; 3-Phenyl-2-oxopropanoic acid; 3-Phenylpyruvate; 3-Phenylpyruvic acid; Phenylpyroracemate; Phenylpyroracemic acid; Phenylpyruvate; alpha-Ketohydrocinnamate; alpha-Ketohydrocinnamic acid; b-Phenylpyruvate; b-Phenylpyruvic acid; keto-Phenylpyruvate; beta-Phenylpyruvate; beta-Phenylpyruvic acid

# Chemical_IUPAC_Name:
2-oxo-3-phenyl-propanoic acid

# Chemical_Formula:
C9H8O3

# Chemical_Structure:
tbl_chemical:::HMDB00205_ZOOM.png:::119283250559930281

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00205_THUMB.png:::119283250387232600

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
ketone; carboxylic acid; aromatic compound

# Taxonomy_Biofunction:
Component of Novobiocin biosynthesis; Component of Phenylalanine metabolism; Component of Phenylalanine, tyrosine and tryptophan biosynthesis; Component of Tyrosine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
164.04735

# Molecular_Weight_Avg:
164.15802

# Smiles_String_isomeric:
OC(=O)C(=O)CC1=CC=CC=C1

# Smiles_String_canonical:
OC(=O)C(=O)CC1=CC=CC=C1

# KEGG_Compound_ID:
C00166

# BioCyc_ID:
PHENYL-PYRUVATE

# PubChem_CID:
997

# PubChem_SID:
7885109; 7890030; 10370382; 3177407; 6900042; 10509223; 3466; 152259; 804876; 7993376; 3064; 830371; 538322; 8145376; 8150916; 825572

# OMIM_ID:
250900

# Metagene_ID:
TYROSINEMIA III: 319; TYROSINEMIA I: 49; TYROSINEMIA II: 66; TYROSINEMIA, TRANSIENT, OF THE NEWBORN: 318; PHENYLKETONURIA (PKU): 135; HAWKINSINURIA: 176

# BiGG_ID:
34111

# Wikipedia_ID:
Not Available

# METLIN_ID:
328

# Ref_ID:
153583; 14708889; 719897; 4025205; 2026685; 9869358; 2291475

# ChEBI_ID:
18005

# CAS_Registry_Number:
156-06-9

# InChI:
InChI=1/C9H8O3/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,11,12)

# Synthesis_Reference:
Aromatic biosynthesis. XI. Aromatization step in the synthesis of phenylalanine.     Weiss, Ulrich; Gilvarg, Charles; Mingioli, Elizabeth S.; Davis, Bernard D.    Cornell Univ. Med. Coll.,  New York,  NY,    Science (Washington, DC, United States)  (1954)

# Melting_Point:
154

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
112 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
0.932 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
1.30 [Predicted by ALOGPS]; 1.1 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Phenylpyruvic acid.pdf:::1132562216232338873

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Phenylpyruvic_acid.mol:::1132723813750179867

# SDF_File_[Text]:
tbl_chemical:::HMDB00205.sdf:::119283250042527348

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00205.pdb:::119283250234546897

# PDB_ID:
1LCO

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041015_P00_01_HW_1DP_presat.png:::115271977056446161

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041015_P00_01_HW_1DP_presat_1.zip:::114684915411264977

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041015_P00_01_HW_2DHSQC_5.png:::114828809622818745

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041015_P00_01_HW_2DHSQC_5.zip:::114828809623484883

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Phenylpyruvic acid.gif:::1132732122015280991

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00205_peaks.txt:::1156309616611232153

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Phenylpyruvic acid_C.gif:::1132737722731984944

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00205_peaks.txt:::1156310805842722650

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; mitochondria

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	0.17 (0.05-0.67)	umol/mmol_creatinine	Adult:>18_yrs_old	Male	Normal	9869358
Urine	0.24 (0.10-0.76)	umol/mmol_creatinine	Adult:>18_yrs_old	Female	Normal	9869358


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Acidosis; Hawkinsinuria; Hypoglycemia; Phenylketonuria (PKU); Tyrosinemia I; Tyrosinemia II; Tyrosinemia III; Tyrosinemia, Transient, of the Newborn

# Pathway_Names:
Alanine and aspartate metabolism

# Pathway_Images:
Aspartate_and_Alanine_metabolism.jpg

# KEGG_Images:
map00252

# Pathway_Graphs:
Aspartate_and_Alanine_metabolism_Graph.jpg

# Pathway_SBMLs:
Aspartate_and_Alanine_metabolism.xml

# Metabolic_Enzyme_1_ID:
5332

# Metabolic_Enzyme_1_Name:
Macrophage migration inhibitory factor

# Metabolic_Enzyme_1_Synonyms:
MIF; Phenylpyruvate tautomerase; Glycosylation-inhibiting factor; GIF

# Metabolic_Enzyme_1_Gene_Name:
MIF

# Metabolic_Enzyme_1_Protein_Sequence:
>Macrophage migration inhibitory factor
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALC
SLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA

# Metabolic_Enzyme_1_Number_of_Residues:
115

# Metabolic_Enzyme_1_Molecular_Weight:
12476

# Metabolic_Enzyme_1_Theoretical_pI:
8.05

# Metabolic_Enzyme_1_GO_Classification:
Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
The expression of MIF at sites of inflammation suggest a role for the mediator in regulating the function of macrophage in host defense. Also acts as a phenylpyruvate tautomerase

# Metabolic_Enzyme_1_Pathway:
map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
GENES       HSA: 4282(MIF);
            MMU: 17319(Mif);
            RNO: 81683(Mif)

# Metabolic_Enzyme_1_Reaction:
keto-phenylpyruvate = enol-phenylpyruvate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01187:MIF

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 5.3.2.1

# Metabolic_Enzyme_1_GenBank_ID_Protein:
188556

# Metabolic_Enzyme_1_SwissProt_ID:
MIF_HUMAN (P14174)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
MIF

# Metabolic_Enzyme_1_Geneatlas_id:
MIF

# Metabolic_Enzyme_1_hgnc_id:
HGNC:7097

# Metabolic_Enzyme_1_PDB_ID:
1GIF

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>348 bp
ATGCCGATGTTCATCGTAAACACCAACGTGCCCCGCGCCTCCGTGCCGGACGGGTTCCTC
TCCGAGCTCACCCAGCAGCTGGCGCAGGCCACCGGCAAGCCCCCCCAGTACATCGCGGTG
CACGTGGTCCCGGACCAGCTCATGGCCTTCGGCGGCTCCAGCGAGCCGTGCGCGCTCTGC
AGCCTGCACAGCATCGGCAAGATCGGCGGCGCGCAGAACCGCTCCTACAGCAAGCTGCTG
TGCGGCCTGCTGGCCGAGCGCCTGCGCATCAGCCCGGACAGGGTCTACATCAACTATTAC
GACATGAACGCGGCCAGTGTGGGCTGGAACAACTCCACCTTCGCCTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M25639

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_1_Locus:
22q11.23

# Metabolic_Enzyme_1_SNPs:
rs34060481; rs34733430; rs17004038; rs36065127; rs2070766; rs33958703; rs2096525; rs34259477; rs36070976; rs2070767; rs4822445; rs4822449; rs4822446; rs4822443; rs4822447; rs4822444; rs4822448; rs36086171; rs12483859; rs35777250; rs2012124; rs2012133; rs2000466; rs12483884; rs12485068; rs755622; rs12485058; rs11428310; rs17004037; rs34648395; rs35859154; rs35235644; rs9282783; rs34775787; rs1049829; rs1803976; rs11548056; rs11548059; rs11548058; rs11548057; rs11548055; rs3191127; rs3191218; rs1803649; rs34914548; rs35565661; rs1050605; rs35468138; rs35625249; rs34690596; rs35833535; rs5844572; rs36224305; rs36224313; rs34741940; rs35212781; rs28718264; rs36223996; rs35017230; rs35074806; rs35006085; rs3063368; rs35688089; rs5844573; rs33919236; rs35178050; rs9624343; rs33919519; rs1007888; rs1007889; rs10427712; rs10427750; rs10433311; rs1129067; rs11703261; rs11703791; rs11703881; rs11913559; rs11913606; rs11914243; rs12628303; rs12628766; rs17004044; rs17004046; rs17004047; rs17004049; rs1984309; rs2000467; rs2000468; rs2000469; rs34096096; rs4820571; rs4822450; rs5751759; rs5751760; rs5751761; rs5760088; rs5760090; rs5760091; rs5760093; rs5760095; rs5996627; rs6003939; rs6003941; rs6003942; rs7284820; rs7287669; rs738806; rs738807; rs8141314; rs8142578; rs875643; rs9612503

# Metabolic_Enzyme_1_General_References:
2552447; 8234256; 8188240; 7947826; 7679497; 1286669; 7683862; 12665801; 11089976; 12681488; 8766818; 8610159; 8643551; 10353846

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5515

# Metabolic_Enzyme_2_Name:
Aspartate aminotransferase, cytoplasmic

# Metabolic_Enzyme_2_Synonyms:
Transaminase A; Glutamate oxaloacetate transaminase 1

# Metabolic_Enzyme_2_Gene_Name:
GOT1

# Metabolic_Enzyme_2_Protein_Sequence:
>Aspartate aminotransferase, cytoplasmic
MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQK
IANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFL
ARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLEN
APEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWA
IRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPP
AQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGM
FSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ

# Metabolic_Enzyme_2_Number_of_Residues:
413

# Metabolic_Enzyme_2_Molecular_Weight:
46248

# Metabolic_Enzyme_2_Theoretical_pI:
7.01

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  transaminase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_2_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00272  Cysteine metabolism;
 map00330  Arginine and proline metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00401  Novobiocin biosynthesis;
 map00710  Carbon fixation;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_2_Reaction:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.6.1.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
179067

# Metabolic_Enzyme_2_SwissProt_ID:
AATC_HUMAN (P17174)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
GOT1

# Metabolic_Enzyme_2_Geneatlas_id:
GOT1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:4432

# Metabolic_Enzyme_2_PDB_ID:
1AJS

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1242 bp
ATGGCACCTCCGTCAGTCTTTGCCGAGGTTCCGCAGGCCCAGCCTGTCCTGGTCTTCAAG
CTCACTGCCGACTTCAGGGAGGATCCGGACCCCCGCAAGGTCAACCTGGGAGTGGGAGCA
TATCGCACGGATGACTGCCATCCCTGGGTTTTGCCAGTAGTGAAGAAAGTGGAGCAGAAG
ATTGCTAATGACAATAGCCTAAATCACGAGTATCTGCCAATCCTGGGCCTGGCTGAGTTC
CGGAGCTGTGCTTCTCGTCTTGCCCTTGGGGATGACAGCCCAGCACTCAAGGAGAAGCGG
GTAGGAGGTGTGCAATCTTTGGGGGGAACAGGTGCACTTCGAATTGGAGCTGATTTCTTA
GCGCGTTGGTACAATGGAACAAACAACAAGAACACACCTGTCTATGTGTCCTCACCAACC
TGGGAGAATCACAATGCTGTGTTTTCCGCTGCTGGTTTTAAAGACATTCGGTCCTATCGC
TACTGGGATGCAGAGAAGAGAGGATTGGACCTCCAGGGCTTCCTGAATGATCTGGAGAAT
GCTCCTGAGTTCTCCATTGTTGTCCTCCACGCCTGTGCACACAACCCAACTGGGATTGAC
CCAACTCCGGAGCAGTGGAAGCAGATTGCTTCTGTCATGAAGCACCGGTTTCTGTTCCCC
TTCTTTGACTCAGCCTATCAGGGCTTCGCATCTGGAAACCTGGAGAGAGATGCCTGGGCC
ATTCGCTATTTTGTGTCTGAAGGCTTCGAGTTCTTCTGTGCCCAGTCCTTCTCCAAGAAC
TTCGGGCTCTACAATGAGAGAGTCGGGAATCTGACTGTGGTTGGAAAAGAACCTGAGAGC
ATCCTGCAAGTCCTTTCCCAGATGGAGAAGATCGTGCGGATTACTTGGTCCAATCCCCCC
GCCCAGGGAGCACGAATTGTGGCCAGCACCCTCTCTAACCCTGAGCTCTTTGAGGAATGG
ACAGGTAATGTGAAGACAATGGCTGACCGGATTCTGACCATGAGATCTGAACTCAGGGCA
CGACTAGAAGCCCTCAAAACCCCTGGGACCTGGAACCACATCACTGATCAAATTGGCATG
TTCAGCTTCACTGGGTTGAACCCCAAGCAGGTTGAGTATCTGGTCAATGAAAAGCACATC
TACCTGCTGCCAAGTGGTCGAATCAACGTGAGTGGCTTAACCACCAAAAATCTAGATTAC
GTGGCCACCTCCATCCATGAAGCAGTCACCAAAATCCAGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M37400

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_2_Locus:
10q24.1-q25.1

# Metabolic_Enzyme_2_SNPs:
rs2234971; rs2641; rs11867; rs1126878; rs11190083; rs2862611; rs4328160; rs4919310; rs11813054; rs3793935; rs4919308; rs17111658; rs3750897; rs2275952; rs7906501; rs7918062; rs7067702; rs9971275; rs9971274; rs11190087; rs11594790; rs12571181; rs12249347; rs10883343; rs11819158; rs4353208; rs3763793; rs11190088; rs17569447; rs3793933; rs7921465; rs12253915; rs3793934; rs2494651; rs10883341; rs2862612; rs2490280; rs12768505; rs17111665; rs2862613; rs17569578; rs4567385; rs11815136; rs10883342; rs10748775; rs4919309; rs17491012; rs12253861; rs11190081; rs2862614; rs12217584; rs11815637; rs12766044; rs17111645; rs17111694; rs4919311; rs12411568; rs11557841; rs4564264; rs41290500; rs11557840; rs1126927; rs11190082; rs2642; rs1802509; rs1802508; rs41290498; rs34854950; rs12777843; rs35687189; rs11394746; rs34971146; rs34646712; rs35478605; rs34582301; rs3045656; rs12252840; rs35736782; rs11378738; rs7918037; rs41400447; rs7896693; rs5787336; rs9731375; rs35003844; rs11456562; rs11313874; rs12358477; rs10668892; rs12241455; rs41436049; rs5787337; rs9971276; rs35500142; rs35096443; rs11456561; rs2902275; rs7899976; rs13377085; rs12777646; rs10629267; rs12414885; rs35193236; rs11325628; rs12777641; rs34254460; rs1892505; rs12776735; rs12776369; rs4917866; rs12775973; rs11816599; rs6584274; rs33928164; rs10786543; rs7917808; rs11429814; rs35546038; rs10716499; rs35665184; rs11190090; rs34122561; rs2234894; rs10748774; rs10786545; rs11190080; rs11190094; rs1132364; rs11592057; rs11598504; rs17111699; rs17490682; rs2298315; rs2298316; rs2490281; rs2490283; rs2494652; rs2494653; rs2494654; rs2862610; rs34183428; rs3750896; rs3793931; rs3793932; rs4345898; rs4917862; rs4917864; rs4919307; rs7099391; rs7914408; rs7920356

# Metabolic_Enzyme_2_General_References:
1974457; 2241899

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5509

# Metabolic_Enzyme_3_Name:
Tyrosine aminotransferase

# Metabolic_Enzyme_3_Synonyms:
L-tyrosine:2-oxoglutarate aminotransferase; TAT

# Metabolic_Enzyme_3_Gene_Name:
TAT

# Metabolic_Enzyme_3_Protein_Sequence:
>Tyrosine aminotransferase
MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAKKTFNPIRAIV
DNMKVKPNPNKTMISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGFLSSRE
EIASYYHCPEAPLEAKDVILTSGCSQAIDLCLAVLANPGQNILVPRPGFSLYKTLAESMG
IEVKLYNLLPEKSWEIDLKQLEYLIDEKTACLIVNNPSNPCGSVFSKRHLQKILAVAARQ
CVPILADEIYGDMVFSDCKYEPLATLSTDVPILSCGGLAKRWLVPGWRLGWILIHDRRDI
FGNEIRDGLVKLSQRILGPCTIVQGALKSILCRTPGEFYHNTLSFLKSNADLCYGALAAI
PGLRPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLVAEQSVHCLPATCFEYPNFIRVVI
TVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK

# Metabolic_Enzyme_3_Number_of_Residues:
454

# Metabolic_Enzyme_3_Molecular_Weight:
50400

# Metabolic_Enzyme_3_Theoretical_pI:
6.24

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  transaminase activity
Function:  tyrosine transaminase activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-sulfur lyase activity
Function:  1-aminocyclopropane-1-carboxylate synthase activity
 ||
>>>
Process:  aromatic amino acid family metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  amino acid catabolism
Process:  aromatic amino acid family catabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
L-tyrosine + 2-oxoglutarate = 4- hydroxyphenylpyruvate + L-glutamate

# Metabolic_Enzyme_3_Pathway:
map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00401  Novobiocin biosynthesis;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_3_Reaction:
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00155:Aminotran_1_2;
PF07706:TAT_ubiq

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.6.1.5

# Metabolic_Enzyme_3_GenBank_ID_Protein:
36713

# Metabolic_Enzyme_3_SwissProt_ID:
ATTY_HUMAN (P17735)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
TAT

# Metabolic_Enzyme_3_Geneatlas_id:
TAT

# Metabolic_Enzyme_3_hgnc_id:
HGNC:11573

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>1365 bp
ATGGACCCATACATGATTCAGATGAGCAGCAAAGGCAACCTCCCCTCAATTCTGGACGTG
CATGTCAACGTTGGTGGGAGAAGCTCTGTGCCGGGAAAAATGAAAGGCAGAAAGGCCAGG
TGGTCTGTGAGGCCCTCAGACATGGCCAAGAAAACTTTCAACCCCATCCGAGCCATTGTG
GACAACATGAAGGTGAAACCAAATCCAAACAAAACCATGATTTCCCTGTCCATTGGGGAC
CCTACTGTGTTTGGAAACCTGCCTACAGACCCTGAAGTTACCCAGGCAATGAAAGATGCC
CTGGACTCGGGCAAATATAATGGCTATGCCCCATCCATCGGCTTCCTATCCAGTCGGGAG
GAGATTGCTTCTTATTACCACTGTCCTGAGGCACCCCTAGAAGCTAAGGACGTCATTCTG
ACAAGTGGCTGCAGCCAAGCTATTGACCTTTGTTTAGCTGTGTTGGCCAACCCAGGGCAG
AACATCCTGGTTCCAAGACCTGGTTTCTCTCTCTACAAGACTCTGGCTGAGTCTATGGGA
ATTGAGGTCAAACTCTACAATTTGTTGCCAGAGAAATCTTGGGAAATTGACCTGAAACAA
CTGGAATATCTAATTGATGAAAAGACAGCTTGTCTCATTGTCAATAATCCATCAAACCCC
TGTGGGTCAGTGTTCAGCAAACGTCATCTTCAGAAGATTCTGGCAGTGGCTGCACGGCAG
TGTGTCCCCATCTTAGCTGATGAGATCTATGGAGACATGGTGTTTTCGGATTGCAAATAT
GAACCACTGGCCACCCTCAGCACCGATGTCCCCATCCTGTCCTGTGGAGGGCTGGCCAAG
CGCTGGCTGGTTCCTGGCTGGAGGTTGGGCTGGATCCTCATTCATGACCGAAGAGACATT
TTTGGCAATGAGATCCGAGATGGGCTGGTGAAGCTGAGTCAGCGCATTTTGGGACCCTGT
ACCATTGTCCAGGGAGCTCTGAAAAGCATCCTATGTCGCACCCCGGGAGAGTTTTACCAC
AACACTCTGAGCTTCCTCAAGTCCAATGCTGATCTCTGTTATGGGGCGTTGGCTGCCATC
CCTGGACTCCGGCCAGTCCGCCCTTCTGGGGCTATGTACCTCATGGTTGGAATTGAGATG
GAACATTTCCCAGAATTTGAGAACGATGTGGAGTTCACGGAGCGGTTAGTTGCTGAGCAG
TCTGTCCACTGCCTCCCAGCAACGTGCTTTGAGTACCCGAATTTCATCCGAGTGGTCATC
ACAGTCCCCGAGGTGATGATGCTGGAGGCGTGCAGCCGGATCCAGGAGTTCTGTGAGCAG
CACTACCATTGTGCTGAAGGCAGCCAGGAGGAGTGTGATAAATAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X52520

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_3_Locus:
16q22.1

# Metabolic_Enzyme_3_SNPs:
rs16973331; rs2432520; rs172650; rs2113223; rs2247603; rs2432519; rs9939332; rs13339247; rs13338868; rs16973337; rs1364210; rs1477386; rs2032921; rs3829537; rs2432521; rs3794689; rs2432522; rs11075889; rs8063455; rs1477387; rs9930543; rs11862798; rs16973344; rs34508506; rs12924334; rs11648913; rs2303226; rs3764308; rs34104038; rs36000068; rs35082722; rs34753286; rs2161674; rs8064108; rs1799881; rs3036400; rs3057106; rs8063793; rs34263853; rs1477388; rs34131262; rs1544808; rs1073060; rs12598228; rs1428834; rs1428835; rs2434886; rs4788809

# Metabolic_Enzyme_3_General_References:
1973834; 7908801; 7999802; 1357662

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
6122

# Metabolic_Enzyme_4_Name:
4-hydroxyphenylpyruvate dioxygenase

# Metabolic_Enzyme_4_Synonyms:
4HPPD; HPD; HPPDase; 4-hydroxyphenylpyruvic acid oxidase

# Metabolic_Enzyme_4_Gene_Name:
HPD

# Metabolic_Enzyme_4_Protein_Sequence:
>4hydroxyphenylpyruvate dioxygenase
MTTYSDKGAKPERGRFLHFHSVTFWVGNAKQAASFYCSKMGFEPLAYRGLETGSREVVSH
VIKQGKIVFV
LSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAKIMR
EPWVEQDKFGKVKFAVLQTYG
DTTHTLVEKMNYIGQFLPGYEAPAFMDPLLPKLPKCSL
EMIDHIVGNQPDQEMVSASEWYLKNLQFHRFW
SVDDTQVHTEYSSLRSIVVANYEESIK
MPINEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRH
LRERGLEFLSVPSTYY
KQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIFTKPVQDRPTLFLEV
IQRHN
HQGFGAGNFNSLFKAFEEEQNLRGNLTNMETNGVVPGM

# Metabolic_Enzyme_4_Number_of_Residues:
393

# Metabolic_Enzyme_4_Molecular_Weight:
44935

# Metabolic_Enzyme_4_Theoretical_pI:
7.01

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
Function:  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Function:  4-hydroxyphenylpyruvate dioxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
4-hydroxyphenylpyruvate + O(2) = homogentisate + CO(2)

# Metabolic_Enzyme_4_Pathway:
map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_4_Reaction:
4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00903:Glyoxalase

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.13.11.27

# Metabolic_Enzyme_4_GenBank_ID_Protein:
3860238

# Metabolic_Enzyme_4_SwissProt_ID:
HPPD_HUMAN (P32754)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
HPD

# Metabolic_Enzyme_4_Geneatlas_id:
HPD

# Metabolic_Enzyme_4_hgnc_id:
HGNC:5147

# Metabolic_Enzyme_4_PDB_ID:
1SQI

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>1182 bp

ATGACGACTTACAGTGACAAAGGGGCAAAGCCTGAGAGAGGCCGATTCCTCCACTTCCA
CTCTGTGACCT
TCTGGGTTGGCAACGCCAAGCAGGCCGCGTCATTCTACTGCAGCAAGA
TGGGCTTTGAACCTCTAGCCTA
CAGGGGCCTGGAGACCGGTTCCCGGGAGGTGGTCAGC
CATGTAATCAAACAAGGGAAGATTGTGTTTGTC
CTCTCCTCAGCGCTCAACCCCTGGAA
CAAAGAGATGGGCGATCACCTGGTGAAACACGGTGACGGAGTGA
AGGACATTGCGTTCG
AGGTGGAAGATTGTGACTACATCGTGCAGAAAGCACGGGAACGGGGCGCCAAAAT
CATG
CGGGAGCCCTGGGTAGAGCAAGACAAGTTTGGGAAGGTGAAGTTTGCTGTGCTGCAGACG
TATGGG
GACACCACACACACCCTGGTGGAGAAGATGAACTACATCGGCCAATTCTTGCC
TGGATATGAGCCCCCAG
CGTTCATGGACCCCCTACTTCCTAAACTGCCCAAATGCAGTC
TGGAGATGATCGACCACATTGTGGGAAA
CCAGCCTGATCAGGAGATGGTGTCCGCCTCC
GAATGGTACCTGAAAAACCTGCAGTTCCACCGCTTCTGG
TCCGTGGATGACACGCAGGT
GCACACGGAATATAGCTCTCTGCGATCCATTGTGGTGGCCAACTATGAAG
AGTCCATCA
AGATGCCCATCAATGAGCCAGCGCCTGGCAAGAAGAAGTCCCAGATCCAGGAATATGTGG
A
CTATAACGGGGGCGCTGGGGTCCAGCACATCGCTCTCAAGACCGAAGACATCATCACA
GCGATTCGCCAC
TTGAGAGAGAGAGGCCTGGAGTTCTTATCTGTTCCCTCCACGTACTA
CAAACAACTGCGGGAGAAGCTGA
AGACGGCCAAGATCAAGGTGAAGGAGAACATTGATG
CCCTGGAGGAGCTGAAAATCCTGGTGGACTACGA
CGAGAAAGGCTACCTCCTGCAGATC
TTCACCAAACCGGTGCAGGACCGGCCCACGCTCTTCCTGGAAGTC
ATCCAGCGCCACAA
CCACCAGGGTTTTGGAGCCGGCAACTTCAACTCACTGTTCAAGGCTTTCGAGGAGG
AGC
AGAACCTGCGGGGTAACCTCACCAACATGGAGACCAATGGGGTGGTGCCCGGCATGTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
U29895

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_4_Locus:
12q24-qter

# Metabolic_Enzyme_4_SNPs:
rs1154510; rs11833399; rs36023382; rs2247291; rs1449562; rs2596140; rs1610041; rs2515729; rs1795963; rs4760102; rs3741587; rs2620334; rs2707072; rs3741586; rs2707056; rs10840622; rs11043214; rs2707070; rs12310752; rs2620340; rs2707055; rs2707075; rs10840623; rs3832816; rs2707058; rs4760103; rs11043217; rs11043213; rs11613865; rs11043216; rs2620339; rs2620332; rs4760105; rs1154515; rs2596144; rs2596143; rs4298948; rs3741591; rs11043218; rs10840619; rs2596142; rs35115987; rs2596139; rs35849100; rs1801436; rs1126925; rs1042843; rs1042844; rs2707063; rs2620354; rs2620333; rs12830647; rs1154512; rs2707074; rs2855415; rs35794561; rs35616764; rs2442440; rs4516009; rs2515730; rs2620350; rs12580755; rs12372468; rs2596145; rs2620337; rs12313193; rs28711529; rs1154516; rs1154511; rs4439557; rs35705173; rs11043212; rs1894285; rs2596141; rs2707054; rs35476559; rs35131803; rs2620347; rs2620349; rs12820413; rs35384269; rs2707071; rs35232597; rs2620338; rs35599566; rs34943778; rs11043211; rs35849071; rs12830638; rs35556469; rs12821095; rs9668731; rs2515731; rs2620335; rs2620346; rs35712089; rs2859577; rs2620348; rs2596138; rs35593190; rs1183890; rs12825630; rs12826129; rs10600651; rs11043210; rs12299502; rs2442441; rs2855414; rs2448483; rs11043215; rs2620336; rs35633723; rs2620341; rs34879391; rs3970383; rs2707057; rs2596146; rs2707073; rs2707062; rs34360786; rs35870123; rs34073901; rs11043219; rs35359220; rs34777671; rs11395265; rs35918033; rs12822028; rs33973864; rs5801455; rs36096665; rs34042138; rs10840624; rs11043207; rs11043222; rs11043223; rs11614326; rs12316702; rs12823194; rs9668191

# Metabolic_Enzyme_4_General_References:
8504803; 7851880; 8521727; 10942115; 11073718

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5516

# Metabolic_Enzyme_5_Name:
Aspartate aminotransferase, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
Transaminase A; Glutamate oxaloacetate transaminase 2

# Metabolic_Enzyme_5_Gene_Name:
GOT2

# Metabolic_Enzyme_5_Protein_Sequence:
>Aspartate aminotransferase, mitochondrial precursor
MALLHSGRVLPGIAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEAFKRDTNSKKM
NLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENSEV
LKSGRFVTVQTISGTGALRIGASFLQRFFKFSRDVFLPKPTWGNHTPIFRDAGMQLQGYR
YYDPKTCGFDFTGAVEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIATVVKKRNLFA
FFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTMVCKDADE
AKRVESQLKILIRPMYSNPPLNGARIAAAILNTPDLRKQWLQEVKGMADRIIGMRTQLVS
NLKKEGSTHNWQHITDQIGMFCFTGLKPEQVERLIKEFSIYMTKDGRISVAGVTSSNVGY
LAHAIHQVTK

# Metabolic_Enzyme_5_Number_of_Residues:
430

# Metabolic_Enzyme_5_Molecular_Weight:
47476

# Metabolic_Enzyme_5_Theoretical_pI:
9.38

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  transaminase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_5_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00272  Cysteine metabolism;
 map00330  Arginine and proline metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00401  Novobiocin biosynthesis;
 map00710  Carbon fixation;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_5_Reaction:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_5_Signals:
1-24

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.6.1.1

# Metabolic_Enzyme_5_GenBank_ID_Protein:
179104

# Metabolic_Enzyme_5_SwissProt_ID:
AATM_HUMAN (P00505)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
GOT2

# Metabolic_Enzyme_5_Geneatlas_id:
GOT2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:4433

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_5_Gene_Sequence:
>1293 bp
ATGGCCCTGCTGCACTCCGGCCGCGTCCTCCCCGGGATCGCCGCCGCCTTCCACCCGGGC
CTCGCCGCCGCGGCCTCTGCCAGAGCCAGCTCCTGGTGGACCCATGTGGAAATGGGACCT
CCAGATCCCATTCTGGGAGTCACTGAAGCCTTTAAGAGGGACACCAATAGCAAAAAGATG
AATCTGGGAGTTGGTGCCTACCGGGATGATAATGGAAAGCCTTACGTTCTGCCTAGCGTC
CGCAAGGCAGAGGCCCAGATTGCCGCAAAAAATTTGGACAAGGAATACCTGCCCATTGGG
GGACTGGCTGAATTTTGCAAGGCATCTGCAGAACTAGCCCTGGGTGAGAACAGCGAAGTC
TTGAAGAGTGGCCGGTTTGTCACTGTGCAGACCATTTCTGGAACTGGAGCCTTAAGGATC
GGAGCCAGTTTTCTGCAAAGATTTTTTAAGTTCAGCCGAGATGTCTTTCTGCCCAAACCA
ACCTGGGGAAACCACACACCCATCTTCAGGGATGCTGGCATGCAGCTACAAGGTTATCGG
TATTATGACCCCAAGACTTGCGGTTTTGACTTCACAGGCGCTGTGGAGGATATTTCAAAA
ATACCAGAGCAGAGTGTTCTTCTTCTGCATGCCTGCGCCCACAATCCCACGGGAGTGGAC
CCGCGTCCGGAACAGTGGAAGGAAATAGCAACAGTGGTGAAGAAAAGGAATCTCTTTGCG
TTCTTTGACATGGCCTACCAAGGCTTTGCCAGTGGTGATGGTGATAAGGATGCCTGGGCT
GTGCGCCACTTCATCGAACAGGGCATTAATGTTTGCCTCTGCCAATCATATGCCAAGAAC
ATGGGCTTATATGGTGAGCGTGTAGGAGCCTTCACTATGGTCTGCAAAGATGCGGATGAA
GCCAAAAGGGTAGAGTCACAGTTGAAGATCTTGATCCGTCCCATGTATTCCAACCCTCCC
CTCAATGGGGCCCGGATTGCTGCTGCCATTCTGAACACCCCAGATTTGCGAAAACAATGG
CTGCAAGAAGTGAAAGGCATGGCTGACCGCATCATTGGCATGCGGACTCAACTGGTCTCC
AACCTCAAGAAGGAGGGTTCCACCCACAATTGGCAACACATCACCGACCAAATTGGCATG
TTCTGTTTCACAGGGCTAAAGCCTGAACAGGTGGAGCGGCTGATCAAGGAGTTCTCCATC
TACATGACAAAAGATGGCCGCATCTCTGTGGCAGGGGTCACCTCCAGCAACGTGGGCTAC
CTTGCCCATGCCATTCACCAGGTCACCAAGTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M22632

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_5_Locus:
16q21

# Metabolic_Enzyme_5_SNPs:
rs30842; rs11076256; rs257636; rs6993; rs7202491; rs11861897; rs257620; rs863944; rs6499971; rs30838; rs30839; rs7204324; rs257616; rs257630; rs1646256; rs8060056; rs6499970; rs30834; rs257617; rs185397; rs257634; rs12600277; rs257618; rs2304490; rs7196291; rs30837; rs9921563; rs1610878; rs4784975; rs9926132; rs257637; rs1646267; rs257631; rs13334922; rs1424245; rs30836; rs190473; rs257633; rs7186087; rs30835; rs173992; rs10500407; rs257649; rs187277; rs9926863; rs40574; rs183757; rs30843; rs1657179; rs7189519; rs1657178; rs2042445; rs7188608; rs257650; rs1803169; rs17849335; rs11558171; rs8059441; rs1058192; rs14221; rs11558167; rs1803168; rs28612351; rs3208672; rs1803170; rs7186105; rs35645687; rs5817158; rs11333258; rs34912264; rs10676089; rs1436429; rs35946557; rs4784974; rs8047219; rs12922626; rs34509416; rs257632; rs35502495; rs12919184; rs7184964; rs9934653; rs9921588; rs4784976; rs13334281; rs9921474; rs12597424; rs7185829; rs13330819; rs28497727; rs34526718; rs7204346; rs3217426; rs11348341; rs34853918; rs257621; rs30840; rs34039790; rs35247174; rs13337034; rs34792826; rs171786; rs30841; rs1657182; rs34180921; rs9923914; rs12921667; rs12933313; rs11299978; rs8046165; rs35323432; rs11423426; rs12932751; rs9933525; rs7186806; rs34289635; rs35324915; rs11439864; rs8046634; rs40575; rs11445492; rs28463297; rs5817159; rs35679170; rs34405351; rs9927670; rs257619; rs35298154; rs3743573; rs8045857; rs9933114; rs8044891; rs35125089; rs35939343; rs7187269; rs257638; rs7194323; rs12923759; rs28472773; rs839418; rs35327432; rs7189104; rs4273028; rs7199783; rs1646260; rs10563758; rs11643959; rs11644269; rs11644290; rs11647748; rs11647808; rs11859875; rs1473205; rs1473206; rs154435; rs1616798; rs1646268; rs3931747; rs4238801; rs4784054; rs4784977; rs6499969; rs7195214; rs7197245

# Metabolic_Enzyme_5_General_References:
3207426; 4052435

# Metabolic_Enzyme_5_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7549

# Macromolecular_Interacting_Partner_1_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
INS

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_1_Signals:
1-24

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
INS

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11p15.5

# Macromolecular_Interacting_Partner_1_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_1_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_1_References:
6347184; 6380597; 6409083

End of HMDB00205

Beginning of HMDB00206
# Accession_No:
HMDB00206

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-02 11:31:45

# biospider_lastupdate:
2007-08-02 11:32:14

# Common_Name:
N6-Acetyl-L-lysine

# Description:
N-acetyl-lysine is an acetylated amino acid. Post-translational lysine-acetylation is one of two major modifications of lysine residues in various proteins. Acetylation of specific lysine residues in the N-terminal domains of core histones is a biochemical marker of active genes. Acetylation is now known to play a major role in eukaryotic transcription. Specifically, acetyltransferase enzymes that act on particular lysine side chains of histones and other proteins are intimately involved in transcriptional activation. By modifying chromatin proteins and transcription-related factors, these acetylases are believed to regulate the transcription of many genes. The best-characterized mechanism is acetylation, catalyzed by histone acetyltransferase (HAT) enzymes. HATs function enzymatically by transferring an acetyl group from acetyl-coenzyme A (acetyl-CoA) to the  -amino group of certain lysine side chains within a histone's basic N-terminal tail region. Within a histone octamer, these regions extend out from the associated globular domains, and in the context of a nucleosome, they are believed to bind the DNA through charge interactions (positively charged histone tails associated with negatively charged DNA) or mediate interactions between nucleosomes. Lysine acetylation, which neutralizes part of a tail region's positive charge, is postulated to weaken histone-DNA or nucleosome-nucleosome interactions and/or signal a conformational change, thereby destabilizing nucleosome structure or arrangement and giving other nuclear factors, such as the transcription complex, more access to a genetic locus. In agreement with this is the fact that acetylated chromatin has long been associated with states of transcriptional activation. Specific recognition of N-acetyl-lysine is a conserved function of all bromodomains found in different proteins, recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progression, apoptosis, DNA repair, and cytoskeletal organization. (PMID  9169194, 10827952, 17340003, 16247734, 9478947, 10839822)

# Synonyms:
L-e-N-Acetyllysine; N-e-Acetyl-L-lysine; N-e-Acetyllysine; N6-Acetyl-L-lysine; N6-Acetyllysine; Ne-Acetyl-L-lysine; Ne-Acetyllysine; e-Acetyl-L-lysine; e-N-Acetyl-L-lysine; e-N-Acetyllysine; w-N-Acetyl-L-lysine; L-epsilon-N-Acetyllysine; N-epsilon-Acetyl-L-lysine; N-epsilon-Acetyllysine; epsilon-Acetyl-L-lysine; epsilon-N-Acetyl-L-lysine; epsilon-N-Acetyllysine; omega-N-Acetyl-L-lysine

# Chemical_IUPAC_Name:
(2S)-6-acetamido-2-amino-hexanoic acid

# Chemical_Formula:
C8H16N2O3

# Chemical_Structure:
tbl_chemical:::HMDB00206_ZOOM.png:::119283251547076956

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00206_THUMB.png:::119283251352947995

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid; secondary carboxylic acid amide; alpha-aminoacid

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
188.11609

# Molecular_Weight_Avg:
188.22424

# Smiles_String_isomeric:
CC(=O)NCCCC[C@H](N)C(O)=O

# Smiles_String_canonical:
CC(=O)NCCCCC(N)C(O)=O

# KEGG_Compound_ID:
C02727

# BioCyc_ID:
CPD-567

# PubChem_CID:
92832

# PubChem_SID:
24890737; 669754; 8144021; 3135400; 5466; 5689; 17161272; 10225608

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Not Available

# METLIN_ID:
5216

# Ref_ID:
6022933

# ChEBI_ID:
17752

# CAS_Registry_Number:
692-04-6

# InChI:
InChI=1/C8H16N2O3/c1-6(11)10-5-3-2-4-7(9)8(12)13/h7H,2-5,9H2,1H3,(H,10,11)(H,12,13)/t7-/m0/s1

# Synthesis_Reference:
N-methoxydiacetamide:  a new selective acetylating agent.     Kikugawa, Yasuo; Mitsui, Kimiyo; Sakamoto, Takeshi; Kawase, Masami; Tamiya, Hiroshi.    Fac. Pharm. Sci.,  Josai Univ.,  Sakado,  Japan.    Tetrahedron Letters  (1990),  31(2),  243-6.

# Melting_Point:
250

# Melting_Point_predicted:
40.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
17.5 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.57 [Predicted by ALOGPS]; -2.7 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::N6-Acetyl-L-lysine.mol:::1132723813828497038

# SDF_File_[Text]:
tbl_chemical:::HMDB00206.sdf:::119283250956428264

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00206.pdb:::119283251214172055

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::050123_P00_10_IS_1DP_presat_expanded_2.gif:::114168246363941934

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::050123_P00_10_IS_1DP_presat.zip:::1175124369243540794

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050123_P00_10_1S_1DP_Assigned.png:::117814293785522733

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050123_P00_10_IS_2DHSQC_2179.png:::117529833767967506

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050123_P00_10_IS_2DHSQC_2179.zip:::117529833770278172

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050123_P00_10_IS_2DHSQC_2179_Assigned.png:::117529833789184136

# Predicted_H_NMR_Spectrum:
tbl_chemical:::N6-Acetyl-L-lysine.gif:::1132732122218329418

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00206_peaks.txt:::1156309617622685536

# Predicted_C_NMR_Spectrum:
tbl_chemical:::N6-Acetyl-L-lysine_C.gif:::1132737723352154755

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00206_peaks.txt:::1156310806864123264

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00206L.png:::117555262899159750; Medium Energy:tbl_ms:::HMDB00206M.png:::11755526819472869; High Energy:tbl_ms:::HMDB00206H.png:::117555271573297260

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP)

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Urine

# Concentration_[Normal]:
Urine	2.036-2.828	umol/mmol_creatinine	Adult:>18_yrs_old	N/A	Normal	6022933


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Not Available

# Pathway_Names:
Lysine degradation

# Pathway_Images:
Lysine_degradation.jpg

# KEGG_Images:
map00310

# Pathway_Graphs:
Lysine_degradation_Graph.jpg

# Pathway_SBMLs:
Lysine_degradation.xml

# Metabolic_Enzyme_1_ID:
5615

# Metabolic_Enzyme_1_Name:
Kynurenine/alpha-aminoadipate aminotransferase mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
KAT/AadAT; Kynurenine--oxoglutarate transaminase II; Kynurenine aminotransferase II; Kynurenine--oxoglutarate aminotransferase II; 2-aminoadipate transaminase; 2- aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AadAT

# Metabolic_Enzyme_1_Gene_Name:
AADAT

# Metabolic_Enzyme_1_Protein_Sequence:
>Kynurenine/alphaaminoadipate aminotransferase mitochondrial precursor
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
IKESL

# Metabolic_Enzyme_1_Number_of_Residues:
425

# Metabolic_Enzyme_1_Molecular_Weight:
47352

# Metabolic_Enzyme_1_Theoretical_pI:
6.96

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Transcription 

# Metabolic_Enzyme_1_Specific_Function:
Shows activity also towards tryptophan, aspartate and hydroxykinurenine

# Metabolic_Enzyme_1_Pathway:
map00300  Lysine biosynthesis;
 map00310  Lysine degradation

# Metabolic_Enzyme_1_Reaction:
L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.6.1.7;EC 2.6.1.39

# Metabolic_Enzyme_1_GenBank_ID_Protein:
6165634

# Metabolic_Enzyme_1_SwissProt_ID:
AADAT_HUMAN (Q8N5Z0)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
AADAT

# Metabolic_Enzyme_1_Geneatlas_id:
AADAT

# Metabolic_Enzyme_1_hgnc_id:
HGNC:17929

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion (Potential)

# Metabolic_Enzyme_1_Gene_Sequence:
>1278 bp
ATGAATTACGCACGGTTCATCACGGCAGCGAGCGCAGCCAGAAACCCTTCTCCCATCCGG
ACCATGACTGACATATTGAGCAGAGGACCAAAATCGATGATCTCCTTGGCTGGTGGCTTA
CCAAATCCAAACATGTTTCCTTTTAAGACTGCCGTAATCACTGTAGAAAATGGAAAGACC
ATCCAATTTGGAGAAGAGATGATGAAGAGAGCACTTCAGTATTCTCCGAGTGCTGGAATT
CCAGAGCTTTTGTCCTGGCTAAAACAGTTACAAATAAAATTGCATAATCCTCCTACCATC
CATTACCCACCCAGTCAAGGACAAATGGATCTATGTGTCACATCTGGCAGCCAACAAGGT
CTTTGTAAGGTGTTTGAAATGATCATTAATCCTGGAGATAATGTCCTCCTAGATGAACCT
GCTTATTCAGGAACTCTTCAAAGTCTGCACCCACTGGGCTGCAACATTATTAATGTTGCC
AGTGATGAAAGTGGGATTGTTCCAGATTCCCTAAGAGACATACTTTCCAGATGGAAACCA
GAAGATGCAAAGAATCCCCAGAAAAACACCCCCAAATTTCTTTATACTGTTCCAAATGGC
AACAACCCTACTGGAAACTCATTAACCAGTGAACGCAAAAAGGAAATCTATGAGCTTGCA
AGAAAATATGATTTCCTCATAATAGAAGATGATCCTTACTATTTTCTCCAGTTTAACAAG
TTCAGGGTACCAACATTTCTTTCCATGGATGTTGATGGACGTGTCATCAGAGCTGACTCT
TTTTCAAAAATCATTTCCTCTGGGTTGAGAATAGGATTTTTAACTGGTCCAAAACCCTTA
ATAGAGAGAGTTATTTTACACATACAAGTTTCAACATTGCACCCCAGCACTTTTAACCAG
CTCATGATATCACAGCTTCTACACGAATGGGGAGAAGAAGGTTTCATGGCTCATGTAGAC
AGGGTTATTGATTTCTATAGTAACCAGAAGGATGCAATACTGGCAGCTGCAGACAAGTGG
TTAACTGGTTTGGCAGAATGGCATGTTCCTGCTGCTGGAATGTTTTTATGGATTAAAGTT
AAAGGCATTAATGATGTAAAAGAACTGATTGAAGAAAAGGCCGTTAAGATGGGGGTATTA
ATGCTCCCTGGAAATGCTTTCTACGTCGATAGCTCAGCTCCTAGCCCTTACTTGAGAGCA
TCCTTCTCTTCAGCTTCTCCAGAACAGATGGATGTGGCCTTCCAGGTATTAGCACAACTT
ATAAAAGAATCTTTATGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF097994

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_1_Locus:
4q33

# Metabolic_Enzyme_1_SNPs:
rs12640652; rs716822; rs6553486; rs11735565; rs11728468; rs2466990; rs1585904; rs2279267; rs1480544; rs2727515; rs3796526; rs6854260; rs6854291; rs17711677; rs6855450; rs2054555; rs11722870; rs963660; rs11731427; rs2622068; rs6553487; rs17546531; rs10213032; rs2466991; rs12502235; rs17628883; rs2622066; rs13145318; rs2331802; rs11731442; rs4145964; rs991247; rs17628775; rs12502178; rs17546559; rs12511967; rs11939395; rs2622069; rs3076683; rs17055413; rs2331801; rs2955255; rs2928819; rs17852900; rs34588185; rs34202278; rs1118262; rs1585903; rs36017064; rs11732763; rs3214945; rs35249526; rs35100741; rs34354891; rs13112109; rs13114656; rs34871790; rs34834671; rs2331804; rs41278617; rs2727516; rs34599867; rs35095178; rs3076682; rs5864015; rs35756932; rs35967487; rs2622071; rs35495254; rs28779786; rs28480175; rs28629414; rs35569089; rs35644368; rs991245; rs35614821; rs35692808; rs36050852; rs13131755; rs2331805; rs2331803; rs2622070; rs35087238; rs34877246; rs35289623; rs35560170; rs13117677; rs35585412; rs4692791; rs2928820; rs34839999; rs36038700; rs4692790; rs35866167; rs12650424; rs1351399; rs17628895; rs2622074; rs2727523; rs2727526; rs2955256; rs34642369; rs34643472; rs4692788

# Metabolic_Enzyme_1_General_References:
Not Available

# Metabolic_Enzyme_1_References:
Not Available

End of HMDB00206

Beginning of HMDB00207
# Accession_No:
HMDB00207

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-24 12:19:16

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Oleic acid

# Description:
An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)   Biological Source: Major constituent of plant oils e.g. olive oil (ca. 80%), almond oil (ca. 80%) and many others, mainly as glyceride. Constituent of tall oil and present in fruits   Use/Importance: Food additive. Used in manuf. of surfactants, soaps, plasticizers. Emulsifying agent in foods and pharmaceuticals.   Biological Use/Importance: Skin penetrant. Herbicide, insecticide, fungicide (Dictionary of Organic Compounds)

# Synonyms:
(9Z)-9-Octadecenoate; (9Z)-9-Octadecenoic acid; (9Z)-Octadecenoate; (9Z)-Octadecenoic acid; (Z)-9-Octadecanoate; (Z)-9-Octadecanoic acid; (Z)-Octadec-9-enoate; (Z)-Octadec-9-enoic acid; 9,10-Octadecenoate; 9,10-Octadecenoic acid; 9-(Z)-octadecenoate; 9-(Z)-octadecenoic acid; 9-Octadecenoate; 9-Octadecenoic acid; Century cd fatty acid; Distoline; Elaate; Elaic acid; Elaidoate; Elaidoic acid; Emersol 210; Emersol 211; Emersol 213; Emersol 220 White Oleate; Emersol 220 White Oleic acid; Emersol 221 Low Titer White Oleate; Emersol 221 Low Titer White Oleic acid; Emersol 233ll; Emersol 6321; Emersol 6333 NF; Emersol 7021; Glycon ro; Glycon wo; Groco 2; Groco 4; Groco 5l; Groco 6; Industrene 104; Industrene 105; Industrene 205; Industrene 206; L'acide oleique; Metaupon; Oelsauere; Oleate; Oleic acid 90-95%; Oleinate; Oleinic acid; Pamolyn; Pamolyn 100; Pamolyn 100 FG; Pamolyn 100 FGK; Pamolyn 125; Priolene 6900; Red oil; Tego-oleic 130; Vopcolene 27; Wecoline OO; Z-9-Octadecenoate; Z-9-Octadecenoic acid; cis-9-Octadecenoate; cis-9-Octadecenoic acid; cis-Octadec-9-enoate; cis-Octadec-9-enoic acid; cis-Oleate; cis-Oleic acid; oleic acid extra pure

# Chemical_IUPAC_Name:
9-Octadecenoic acid

# Chemical_Formula:
C18H34O2

# Chemical_Structure:
tbl_chemical:::HMDB00207_ZOOM.png:::119283252579983852

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00207_THUMB.png:::119283252376444512

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Fatty Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
carboxylic acid; alkene

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
282.25589

# Molecular_Weight_Avg:
282.46136

# Smiles_String_isomeric:
CCCCCCCCC=C/CCCCCCCC(O)=O

# Smiles_String_canonical:
CCCCCCCCC=CCCCCCCCC(O)=O

# KEGG_Compound_ID:
C00712

# BioCyc_ID:
OLEATE-CPD

# PubChem_CID:
965

# PubChem_SID:
3978; 11446962; 11455589; 7849374; 4850; 11446555; 5309210; 3031

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Oleic acid

# METLIN_ID:
190

# Ref_ID:
11428654; 7593616; 15602154; 10391868; 12833107; 10970994; 8947319; 14665727; 11033078; 10341674; 11453902; 7929039; 16182414; 9113419; 8412012; 12829627; 11124748; 16249438; 10522608; 12948025

# ChEBI_ID:
16196

# CAS_Registry_Number:
112-80-1

# InChI:
InChI=1/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-

# Synthesis_Reference:
 Journal of the American Chemical Society  (1948),  70  695-8.

# Melting_Point:
13.4 oC

# Melting_Point_predicted:
36.9 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
1.15e-05 mg/mL [MEYLAN,WM et al. (1996)]; 1.21e-04 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Liquid

# LogP:
Not Available

# LogP_predicted:
7.68 [Predicted by ALOGPS]; 6.5 [Predicted by PubChem via XLOGP]; 7.73 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Oleic acid.pdf:::1132562216512978309

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Oleic_acid.mol:::1132723813921862637

# SDF_File_[Text]:
tbl_chemical:::HMDB00207.sdf:::119283251965916852

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00207.pdb:::119283252236997068

# PDB_ID:
1FE3

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::00207_Oleic acid.zip:::118237380872696556

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041102_P00_05_HW_assigned.png:::118237380873711529

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041102_P00_05_HW_2DHSQC_14.png:::11482879019807504

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041102_P00_05_HW_2DHSQC_14.zip:::114828790198477673

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041102_P00_05_HW_2DHSQC_14_Assigned.png:::116302600190155515

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Oleic acid.gif:::1132732122437925634

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00207_peaks.txt:::1156309618651232979

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Oleic acid_C.gif:::1132737723933641622

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00207_peaks.txt:::1156310807881208342

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane (Predicted from LogP)

# Tissue_Location:
Adipose Tissue; Intestine; Liver; Muscle; Pancreas; Placenta; Skeletal Muscle; Skin; Stratum Corneum

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Feces

# Concentration_[Normal]:
Blood	460.0 (120.0-1830.0)	umol/L	Adult:>18_yrs_old	Both	Normal	8412012
Blood	37.0 +/- 5.7	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	36.0 +/- 36.0	umol/L	Adult:>18_yrs_old	N/A	Normal	8412012


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Lymphoma; Neuroblastoma; Pulmonary Edema

# Pathway_Names:
Fatty acid biosynthesis (path 1)

# Pathway_Images:
Not Available

# KEGG_Images:
map00061

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5264

# Metabolic_Enzyme_1_Name:
Fatty acid synthase

# Metabolic_Enzyme_1_Synonyms:
Not Available

# Metabolic_Enzyme_1_Gene_Name:
FASN

# Metabolic_Enzyme_1_Protein_Sequence:
>Fatty acid synthase
MEEVVIAGMSGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGLYGLPRRSGKLKDLSRF
DASFFGVHPK
QAHTMDPQLRLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETSEA
LSRDPETLVGYSMVGCQRAMM
ANRLSFFFDFRGPSIALDTACSSSLMALQNAYQAIHSG
QCPAAIVGGINVLLKPNTSVQFLRLGMLSPEG
TCKAFDTAGNGYCRSEGVVAVLLTKKS
LARRVYATILNAGTNTDGFKEQGVTFPSGDIQEQLIRSLYQSA
GVAPESFEYIEAHGTG
TKVGDPQELNGITRALCATRQEPLLIGSTKSNMGHPEPASGLAALAKVLLSLEH
GLWAP
NLHFHSPNPEIPALLDGRLQVVDQPLPVRGGNVGINSFGFGGSNVHIILRPNTQPPPAPA
PHATL
PRLLRASGRTPEAVQKLLEQGLRHSQDLAFLSMLNDIAAVPATAMPFRGYAVLG
GERGGPEVQQVPAGER
PLWFICSGMGTQWRGMGLSLMRLDRFRDSILRSDEAVKPFGLK
VSQLLLSTDESTFDDIVHSFVSLTAIQ
IGLIDLLSCMGLRPDGIVGHSLGEVACGYADG
CLSQEEAVLAAYWRGQCIKEAHLPPGAMAAVGLSWEEC
KQRCPPGVVPACHNSKDTVTI
SGPQAPVFEFVEQLRKEGVFAKEVRTGGMAFHSYFMEAIAPPLLQELKK
VIREPKPRSA
RWLSTSIPEAQWHSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPHALLQAV

LKRGLKPSCTIIPLMKKDHRDNLEFFLAGIGRLHLSGIDANPNALFPPVEFPAPRGTPL
ISPLIKWDHSL
AWDVPAAEDFPNGSGSPSAAIYNIDTSSESPDHYLVDHTLDGRVLFPA
TGYLSIVWKTLARALGLGVEQL
PVVFEDVVLHQATILPKTGTVSLEVRLLEASRAFEVS
ENGNLVVSGKVYQWDDPDPRLFDHPESPTPNPT
EPLFLAQAEVYKELRLRGYDYGPHFQ
GILEASLEGDSGRLLWKDNWVSFMDTMLQMSILGSAKHGLYLPT
RVTAIHIDPATHRQK
LYTLQDKAQVADVVVSRWLRVTVAGGVHISGLHTESAPRRQQEQQVPILEKFCFT
PHTE
EGCLSERAALQEELQLCKGLVQALQTTVTQQGLKMVVPGLDGAQIPRDPSQQELPRLLSA
ACRLQL
NGNLQLELAQVLAQERPKLPEDPLLSGLLDSPALKACLDTAVENMPSLKMKVV
EVLAGHGHLYSRIPGLL
SPHPLLQLSYTATDRHPQALEAAQAELQQHDVAQGQWDPADP
APSALGSADLLVCNCAVAALGDPASALS
NMVAALREGGFLLLHTLLRGHPLGDIVAFLT
STEPQYGQGILSQDAWESLFSRVSLRLVGLKKSFYGSTL
FLCRRPTPQDSPIFLPVDDT
SFRWVESLKGILADEDSSRPVWLKAINCATSGVVGLVNCLRREPGGNRLR
CVLLSNLSS
TSHVPEVDPGSAELQKVLQGDLVMNVYRDGAWGAFRHFLLEEDKPEEPTAHAFVSTLTRG
D
LSSIRWVCSSLRHAQPTCPGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSL
LGMEFSGRDASG
KRVMGLVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYY
ALVVRGRVRPGETLLIHSGSGGV
GQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLD
STSFANSRDTSFEQHVLWHTGGKGVDLVLNSLAE
EKLQASVRCLATHGRFLEIGKFDLS
QNHPLGMAIFLKNVTFHGVLLDAFFNESSADWREVWALVQAGIRD
GVVRPLKCTVFHGA
QVEDAFRYMAQGKHIGKVVVQVLAEEPEAVLKGAKPKLMSAISKTFCPAHKSYIIA
GGL
GGFGLELAQWLIQRGVQKLVLTSRSGIRTGYQAKQVRRWRRQGVQVQVSTSNISSLEGAR
GLIAEAA
QLGPVGGVFNLAVVLRDGLLENQTPEFFQDVCKPKYSGTLNLDRVTREACPE
LDYFVVFSSVSCGRGNAG
QSNYGFANSAMERICEKRRHEGLPGLAVQWGAIGDVGILVE
TMSTNDTIVSGTLPQRMASCLEVLDLFLN
QPHMVLSSFVLAEKAAAYRDRDSQRDLVEA
VAHILGIRDLAAVNLDSSLADLGLDSLMSVEVRQTLEREL
NLVLSVREVRQLTLRKLQE
LSSKADEASELACPTPKEDGLAQQQTQLNLRSLLVNPEGPTLMRLNSVQSS
ERPLFLVH
PIEGSTTVFHSLASRLSIPTYGLQCTRAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYS
YG
ACVAFEMCSQLQAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCEAEAETEA
ICFFVQQFTDMEH
NRVLEALLPLKGLEERVAAAVDLIIKSHQGLDRQELSFAARSFYYK
LRAAEQYTPKAKYHGNVMLLRAKT
GGAYGEDLGADYNLSQVCDGKVSVHVIEGDHRTLL
EGSGLESIISIIHSSLAEPRVSVREG

# Metabolic_Enzyme_1_Number_of_Residues:
2511

# Metabolic_Enzyme_1_Molecular_Weight:
273403

# Metabolic_Enzyme_1_Theoretical_pI:
6.39

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  oxidoreductase activity
Function:  vitamin binding
Function:  phosphopantetheine binding
Function:  binding
Function:  cofactor binding
Function:  catalytic activity
Function:  transferase activity
 ||
>>>
Process:  biosynthesis
Process:  cellular metabolism
Process:  organic acid metabolism
Process:  carboxylic acid metabolism
Process:  fatty acid metabolism
Process:  fatty acid biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_1_Specific_Function:
Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein

# Metabolic_Enzyme_1_Pathway:
map00061  Fatty acid biosynthesis (path 1)

# Metabolic_Enzyme_1_Reaction:
(3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00698:Acyl_transf_1;
PF00106:adh_short;
PF00107:ADH_zinc_N;
PF00109:ketoacyl-synt;
PF02801:Ketoacyl-synt_C;
PF08242:Methyltransf_12;
PF00550:PP-binding;
PF00975:Thioesterase

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.3.1.85;EC 2.3.1.38;E

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1049053

# Metabolic_Enzyme_1_SwissProt_ID:
FAS_HUMAN (P49327)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
FASN

# Metabolic_Enzyme_1_Geneatlas_id:
FASN

# Metabolic_Enzyme_1_hgnc_id:
HGNC:3594

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Metabolic_Enzyme_1_Gene_Sequence:
>7515 bp

ATGGAGGAGGTGGTGATTGCCGGCATGTTCGGGAAGCTGCCAGAGTCGGAGAACTTGCA
GGAGTTCTGGG
ACAACCTCATCGGCGGTGTGGACATGGTCACGGACGATGACCGTCGCT
GGAAGGCTGGGCTCTACGGCCT
GCCCCGGCGGTCCGGCAAGCTGAAGGACCTGTCTAGG
TTTGATGCCTCCTTCTTCGGAGTCCACCCCAAG
CAGGCACACACGATGGACCCTCAGCT
GCGGCTGCTGCTGGAAGCTACCTATGAAGCCATCGTGGACGGAG
GCATCAACCCAGATT
CACTCCGAGGAACACACACTGGCGTCTGGGTGGGCGTGAGCGGCTCTGAGACCTC
GGAG
GCCCTGAGCCGAGACCCCGAGACACTCGTGGGCTACAGCATGGTGGGCTGCCAGCGAGCG
ATGATG
GCCAACCGGCTCTCCTTCTTCTTCGACTTCAGAGGGCCCAGCATCGCACTGGA
CACAGCCTGCTCCTCCA
GCCTGATGGCCCTGCAGAACGCCTACCAGGCCATCCACAGCG
GGCAGTGCCCTGCCGCCATCGTGGGGGG
CATCAACGTCCTGCTGAAGCCCAACACCTCC
GTGCAGTTCTTGAGGCTGGGGATGCTCAGCCCCGAGGGC
ACCTGCAAGGCCTTCGACAC
AGCGGGGAATGGGTACTGCCGCTCGGAGGGTGTGGTGGCTGTCCTGCTGA
CCAAGAAGT
CCCTGGCCCGGAAGGTCTACACCACCATCCTGAACAAAGGCACCAATACAGATGGCTTCA
A
GGAGCAAGGCGTGACCTTCCCTCAGGATATCCAGGAGCAGCCTATCCGCTCGTTGTAC
CAGTCGGCCGGA
GTGGCCCCTGAGTCATTTGAATACATCGAAGCCCACGGACCAGGCAC
CAAGGTGGGCGACCCCCAGGAGC
GTAATGGCATCACCCGAGCCCTGTGCGCCACCCGCC
AGGAGCCGCTGCTCATCGGCTCCACCAAGTCCAA
CATGGGGCACCCGGAGCCAGCCTCG
GGGCTCGACGCCCTGGCCAAGGTGCTGCTGTCCCTGGAGCACGGG
CTCTGGGCCCCCAA
CCTGCACTTCCATAGCCCCAACCCTGAGATCCCAGCGCTGTTGGATGGGCGGCTGC
AGG
TGGTGGACCAGCCCCTGCCCGTCCGTGGCGGCAACGTGGGCATCAACTCCTTTGGCTTCG
GGGGCTC
CAACATGCACATCATCCTGAGGCCCAACACGCAGTCCGCCCCCGCACCCGCC
CCACATGCCACCCTGCCC
CGTCTGCTGCGGGCCAGCGGACGCACCCCTGAGGCCGTGCA
GAAGCTGCTGGAGCAGGGCCTCCGGCACA
GCCAGGGCCTGGCTTTCCTGAGCATGCTGA
ACGACATCGCGGCTGTCCCCGCCACCGCCATGCCCTTCCG
TGGCTACGCTGTGCTGGGT
GGTGAGACGCGGTGGCCCAGAGTGCAGCAGGTGCCCGCTGGCGAGCGCCCG
CTCTGGTT
CATCTGCTCTGGGATGGGCACACAGTGGCGTGGAATGGGGCTGAGCCTTATGCGCCTGGA
CC
GCTTCCGAGATTCCATCCTACGCTCCGATGAGGCTGTGAACCGATTCGGCCTGAAGG
TGTCACAGCTGCT
GCTGAGCACAGACGAGAGCACCTTTGATGACATCGTCCATTCGTTT
GTGAGCCTGACTGCCATCCAGATA
GGCCTCATAGACCTGCTGAGCTGCATGGGACCTGA
GGCAGATGGCATCGTCGGCCACTCCCTGGGGGAGT
GGCTGTCGGTACGCGACGGCTGCC
TGTCCCAGGAGGAGGCCGTCCTCGCTGCCTACTGGAGGGGACAGTG
CATCAAAGAAGCC
CCACTTCCCGCCGGCGCCATGGCAGCCGTGGGCTTGTCCTGGGAGGAGTGTAAACAG
CG
CTGCCCCCCTGCGGTGGTGCCCGCCTGCCACAACTCCAAGGACACAGTCACCATCTCGGG
ACCTCAGG
CCCCGGTGTTTGAGTTCGTGGAGCAGCTGAGGAAGGAGGGTGTGTTTGCCA
AGGAGGTGCGGACCGGCGG
TATGGCCTTCCACTCCTACTTCATGGAGGCCATCGCACCC
CCACTGCTGCAGGAGCTCAAGAAGGTGATC
CGGGAGCCGAAGCCACGTTCAGCCCGCTG
GCTCAGCACCTCTATCCCCGAGGCCCAGTGGCACAGCAGCC
TGGCACGCACGTCTTCCG
CCGAGTACAATGTCAACAACCTGGTGAGCCCTGTGCTGTTCCAGGAGGCCCT
GTGGCAC
GTGCCTGAGCACGCGGTGGTGCTGGAGATCGCCCCGACCCCGTGCCCTCAGGCTGTCCTG
AAG
CGGGTCCGTAAGCCGAGCTGCACCATCATCCCCCGTATGAAGAAGGATCACAGGGA
CAACCTGGAGTTCT
TCCTGGCCGGCATCGGCAGGCTGCACCTCTCAGGCATCGACGCCA
ACCCCAATGCCTTGTTCCCACCTGT
GGAGTCCCCAGCTCCCCGAGGAACTCCCCTCATC
TCCCCACTCATCAAGTGGGACCACAGCCTGGCCTGG
GACGCGCCGGCCGCCGAGGACTT
CCCCAACGGTTCAGGTTCCCCCTCAGCCACCATCTACACATGCACAC
CAAGCTCCGAGT
CTCCTGACCGCTACCTGGTGGACCACACCATCGACGGTCGCGTCCTCTTCCCCGCCAC
T
GGCTACCTGAGCATAGTGTGGAAGACGCTGGCCCGCGCCTGGGCTGGGCTCGAGCAGCTG
CCTGTGGTG
TTTGAGGATGTGGTGCAGCACCAGGCCACCATCCTGCCCAAGACTGGGAC
AGTGTCCTTGGAGGTACGGC
TCCTGGAGGCCACCGGTGCCTTCGAGGTGTCAGAGAACG
GCAACCTGGTAGTGAGTGGGAAGGTGTACCA
GTGGGATGACCCTGACCCCAGGCTCTTC
GACCACCCGGAAAGTCCCCACCCCAATTCCCCACGGAGTCCC
CTCTTCCTGGCCCAGGC
AGAAGTTTACAAGGAGCTGCGTCTGCGTGGCTACGACTACGGCCCTCATTTCC
AGGGCA
TCCTGGAGGCCAGCCTGGAAGGTGACTCGGGGAGGCTGCTGTGGAAGGATAACTGGGTGA
GCTT
CATGGACACCATGCTGCAGATGTCCATCCTGGGCTCGGCCAAGCACGGCCTGTAC
CTACCCACCCGTGTC
ACCGCCATCCACATCGACCCTGCCACCCACAGGCAGAAGCTGTA
CACACTGCAGGACAAGGCCCAAGTGG
CTGACGTGGTGGTGAGCAGGTGGCCGAGGGTCA
CAGTGGCGGGAGGCGTCCACATCTCCGGGCTCCACAC
TGAGTCGGCCCCGCGGCGGCAC
GAGGAGCAGCAGGTGCCCATCCTGGAGAAGTTTTGCTTCACTCCCCAC
ACGGAGGAGGG
GTGCCTGTCTGAGCACGCTGCCCTCGAGGAGGAGCTGCAACTGTGCAAGGGGCTGGTCG
AGGCACTCGAGACCAAGGTGACCCAGCAGGGGCTGAAGATGGTGGTGCCGGACTGGACGG
GGCCCAGATC
CCCCCGGGACCCCTCACAGCAGGAACTGCCCCGGCTGTTGTCGGCTGCC
TGCAGGCTTCAGCTCAACGGG
AACCTGCAGCTGGAGCTGGCGCAGGTGCTGGCCCAGGA
GAGGCCCAAGCTGCCAGAGGACCCTCTGCTCA
GCGGCCTCCTGGACTCCCCGGCACTCA
AGGCCTGCCTGGACACTGCCGTGGAGAACATGCCCAGCCTGAA
GATGAAGGTGGTGGAG
GTGCTGGCCGGCCACGGTCACCTGTATTCCCGCATCCCAGGCCTGCTCAGCCCC
CATCC
CCTGCTGCAGCTGAGCTACACGGCCACCGACCGCCACCCCCAGGCCCTGGAGGCTGCCCA
GGCCG
AGCTGCAGCAGCACGACGTTGCCCAGGGCCAGTGGGATCCCGCAGACCCTGCCC
CCAGCGCCCTGGGCAG
CGCGGACCTCCTGGTGTGCAACTGTGCTGTGGCTGCCCTCGGG
GACCCGGCCTCAGCTCTCAGCAACATG
GTGGCTGCCCTGAGAGAAGGGGGCTTTCTGCT
CCTGCACACACTGCTCCGGGGGCACCCTCGGGACATCG
TGGCCTTCCTCACCTCCACTG
AGCCGCAGTATGGCCAGGGCATCCTGAGCCAGGACGCGTGGGAGAGCCT
CTTCTCCAGG
GTGTCGCTGCGCCTGGTGGGCCTGAAGAAGTCCTTCTACGGCGCCACGCTCTTCCTGTGC

CGCCGGCCCACCCCGCAGGACAGCCCCATCTTCCTGCCGGTGGACGATACCAGCTTCCG
CTGGGTGGAGT
CTCTGAAGGGCATCCTGGCTGACGAAGACTCTTCCCGGCCTGTGTGGC
TGAAGGCCATCAACTGTGCCAC
CTCGGGCGTGGTGGGCTTGGTGAACTGTCTCCGCCGA
GAGCCCGGCGGAACCGTCCGGTGTGTGCTGCTC
TCCAACCTCAGCAGCACCTCCCACGT
CCCGGAGGTGGACCCGGGCTCCGCAGAACTGCAGAAGGTGTTGC
AGGGAGACCTGGTGA
TGAACGTCTACCGCGACGGGGCCTGGGGGGTTTTCCGCCACTTCCTGCTGGAGGA
CAAG
CCTGAGGAGCCGACGGCACATGCCTTTGTGAGCACCCTCACCCGGGGGGACCTGTCCTCC
ATCCGC
TGGGTCTGCTCCTCGCTGCGCCATGCCCAGCCCACCTGCCCTGGCGCCCAGCT
CTGCACGGTCTACTACG
CCTCCCTCAACTTCCGCGACATCATGCTGGCCACTGGCAAGC
TGTCCCCTGATGCCATCCCAGGGAAGTG
GACCTCCCAGGACAGCCTGCTAGGTATGGAG
TTCTCGGGCCGAGACGCCAGCGGCAAGCGTGTGATGGGA
CTGGTGCCTGCCAAGGGCCT
GGCCACCTCTGTCCTGCTGTCACCGGACTTCCTCTGGGATGTGCCTTCCA
ACTGGACGC
TGGAGGAGGCGGCCTCGGTGCCTGTCGTCTACAGCACGGCCTACTACGCGCTGGTGGTGC
G
TGGGCGGGTGCGCCCCGGGGAGACGCTGCTCATCCACTCGGGCTCGGGCGGCGTGGGC
CAGGCCGCCATC
GCCATCGCCCTCAGTCTGGGCTGCCGCGTCTTCACCACCGTGGGGTC
GGCTGAGAAGCGGGCGTACCTCC
AGGCCAGGTTCCCCCAGCTCGACAGCACCAGCTTCG
CCAACTCCCGGGACACATCCTTCGAGCAGCATGT
GCTGTGGCACACGGGCGGGAAGGGC
GTTGACCTGGTCTTGAACTCCTTGGCGGAAGAGAAGCTGCAGGCC
AGCGTGAGGTGCTT
CGGTACGCACGGTCGCTTCCTGGAAATTGGCAAATTCGACCTTTCTCAGAACCACC
CGC
TCGGCATGGCTATCTTCCTGAAGAACGTGACATTCCACGGGGTCCTACTGGATGCGTTCT
TCAACGA
GAGCAGTGCTGACTGGCGGGAGGTGTGGGCGCTTGTCGAGGCCGCCATCCGG
GATGGGGTGGTACGGCCC
CTCAAGTGCACGGTGTTCCATGGGGCCCAGGTGGAGGACGC
CTTCCGCTACATGGCCCAAGGGAAGCACA
TTGGCAAAGTCGTCGTGCAGGTGCTTGCGG
AGGAGCCGGCAGTGCTGAAGGGGGCCAAACCCAAGCTGAT
GTCGGCCATCTCCAAGACC
TTCTGCCCGGCCCACAAGAGCTACATCATCGCTGGTGGTCTGGGTGGCTTC
GGCCTGGA
GTTGGCGCAGTGGCTGATACAGCGTGGGGTGCAGAAGCTCGTGTTGACTTCTCGCTCCGG
GA
TCCGGACAGGCTACCAGGCCAAGCAGGTCCGCCGGTGGAGGCGCCAGGGGCTACAGG
TGCAGGTGTCCAC
CAGCAACATCAGCTCACTGGAGGGGGCCCGGGGCCTCATTGCCGAG
GCGGCGCAGCTTGGGCCCGTGGGG
GGCGTCTTCAACCTGGCCGTGGTCTTGAGAGATGG
CTTGCTGGAGAACCAGACCCCAGAGTTCTTCCAGG
ACGTCTGCAAGCCCAAGTACAGCG
GCACCCTGAACCTGGACAGGGTGACCCGAGAGGCGTGCCCTGAGCT
GGACTACTTTGTG
GTCTTCTCCTCTGTGAGCTGCGGGCGTGGCAATGCGGGACAGAGCAACTACGGCTTT
GC
CAATTCCGCCATGGAGCGTATCTGTGAGAAACGCCGGCACGAAGGCCTCCCAGGCCTGGC
CGTGCAGT
GGGGCGCCATCGGCACCGTGGGCATTTTGGTGGAGACGATGAGCACCAACG
ACACGATCGTCAGTGGCAC
GCTGCCCACGCGCATTGGCGTCCTTGGCCTGGAGGTGCTG
GACCTCTTCCTGAACCAGCCCCACATGGTC
CTGAGCAGCTTTGTGCTGGCTGAGAAGGC
TGCGGCCTATAGGGACAGGGACAGCCAGCGGGACCTGGTGG
AGGCCGTGGCACACATCC
TGGGCATCCGCGACTTGGCTGCTGTCAACCTGGGCGGCTCACTGGCGGACCT
GGGCCTG
GACTCGCTCATGAGCGCGCCGGTGCGCCAGACGCTGGAGCGTGAGCTCAACCTGGTGCTG
TCC
GTGCGCGAGGTGCGGCAACTCACGCTCCGGAAACTGCAGGAGCTGTCCTCAAAGGC
GGATGAAGCCAGCG
AGCTGGCATGCCCCACGCCCAAGGAGGATGGTCTGGCCCAGCAGC
AGACTCAGCTGAACCTGCGCTCCCT
GCTGGTGAAACCGGAGGGCCCCACCCTGATGCGG
CTCAACTCCGTGCAGAGCTCGGAGCGGCCCCTGTTC
CTGGTGCACCCAATCGAGGCTAC
CACCGTGTTCCACAGCCTCGGTCCCGGTCTCAGCATCCCCACCTATG
GCCTGCAGTGCA
CCCCGGCTGCGCCCCTTGACAGCATCCACAGCCTGGCTGCCTACTACATCGACTGCAT
C
AGGCAGGTGCAGCCCGAGGGCCCCTACCGCGTGGCCGGCTACTCCTACGGGGCCTGCGTG
GCCTTTGAA
ATGTGCTCCCAGCTGCAGGCCCAGCAGAGCCCAGCCCCCACCCACAACAG
CCTCTTCCTGTTCGACGGCT
CGCCCACCTACGTACTGGCCTACACCCAGAGCTACCGGG
CAAAGCTGACCCCAGGCTGTAAGGCTGAGGC
TGAGACGGAGGCCATATGCTTCTTCGTG
CAGCAGTTCACGGACATGGAGCACAACAGGGTGCTGGAGGCG
CTGCTGCCGCTGAAGGG
CCTAGAGGAGCGTGTGGCAGCCGCCGTGGACCTGATCATCAAGAGCCACCAGG
GCCTGG
ACCGCCAGGAGCTGAGCTTTGCGGCCCGGTCCTTCTACTACAGGCTGCGTGCCGCTGACC
AGTA
TACACCCAAGGCCAAGTACAGTGGCAACGTGATGCTACTGCGGGCCAAGACGGGT
GGCCGCTACGGCGAG
GACCTGGGCGCGGACTACAACCTCTCCCAGGTATGCGACGGGAA
AGTATCCGTCCATATCATCGAGGGTG
ACCACCGCACGCTGCTGGAGGGCAGCGGCCTGG
AGTCCATCATCAGCATCATCCACAGCTCCCTGGCTGA
GCCACGTGTGAGTCGGGAGGGC
TAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U26644

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_1_Locus:
17q25

# Metabolic_Enzyme_1_SNPs:
rs2228307; rs2229424; rs2228305; rs4485435; rs2229422; rs2229421; rs1140616; rs2228309; rs11550611; rs4246444; rs4246445; rs9905991; rs4969465; rs4969486; rs4075080; rs4502283; rs12937862; rs11077968; rs9891602; rs7215515; rs8066956; rs12949488; rs17848956; rs7222326; rs17848929; rs34019652; rs2228306; rs41283363; rs41283367; rs17848945; rs1140617; rs1140623; rs4363911; rs17848949; rs17848948; rs1140618; rs1140613; rs17855788; rs9890362; rs2229426; rs2229423; rs1140614; rs12946178; rs1140612; rs11550612; rs1140610; rs1140606; rs17848946; rs1140607; rs1140624; rs41283365; rs1140608; rs17848933; rs11550614; rs2229425; rs17848930; rs34179714; rs1140622; rs1140609; rs1140611; rs4547403; rs17848940; rs1140621; rs1140619; rs17855165; rs17848934; rs15324; rs1051138; rs34326255; rs17848939; rs17848941; rs17848925; rs41283371; rs17848958; rs17848963; rs17848931; rs17848955; rs17848942; rs17848961; rs17848959; rs34334536; rs9904054; rs17848924; rs17848962; rs9901600; rs41283361; rs17848927; rs17848950; rs4969466; rs34553245; rs17848960; rs12952709; rs9898060; rs41283369; rs12450902; rs17848951; rs17848935; rs17848926; rs9895384; rs17848937; rs17848944; rs17848932; rs8078234; rs10591316; rs35388606; rs17848954; rs9893404; rs11655220; rs12946373; rs34731893; rs17848953; rs11653745; rs11655217; rs11284316; rs34272050; rs34359605; rs10645484; rs7209621; rs34151210; rs34528587; rs1127678; rs11653003; rs11655646; rs11658040; rs12325930; rs4969485; rs6416857; rs6502050; rs6502051; rs7225637; rs8065606

# Metabolic_Enzyme_1_General_References:
7567999; 8022791; 7595075

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5608

# Metabolic_Enzyme_2_Name:
Alpha-lactalbumin precursor

# Metabolic_Enzyme_2_Synonyms:
Lactose synthase B protein; Lysozyme- like protein 7

# Metabolic_Enzyme_2_Gene_Name:
LALBA

# Metabolic_Enzyme_2_Protein_Sequence:
>Alphalactalbumin precursor
MRFFVPLFLVGILFPAILAKQFTKCELSQLLKDIDGYGGIALPELICTMFHTSGYDTQAI
VENNESTEYGLFQISNKLWCKSSQVPQSRNICDISCDKFLDDDITDDIMCAKKILDIKGI
DYWLAHKALCTEKLEQWLCEKL

# Metabolic_Enzyme_2_Number_of_Residues:
142

# Metabolic_Enzyme_2_Molecular_Weight:
16225

# Metabolic_Enzyme_2_Theoretical_pI:
4.60

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  UDP-glycosyltransferase activity
Function:  UDP-galactosyltransferase activity
Function:  lactose synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
Process:  cellular carbohydrate metabolism
Process:  disaccharide metabolism
Process:  lactose metabolism
Process:  lactose biosynthesis
 ||
>>>
Component:  extracellular region

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins

# Metabolic_Enzyme_2_Pathway:
Not Available

# Metabolic_Enzyme_2_Reaction:
Not Available

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00062:Lys

# Metabolic_Enzyme_2_Signals:
1-19

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.4.1.22

# Metabolic_Enzyme_2_GenBank_ID_Protein:
307104

# Metabolic_Enzyme_2_SwissProt_ID:
LALBA_HUMAN (P00709)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
LALBA

# Metabolic_Enzyme_2_Geneatlas_id:
LALBA

# Metabolic_Enzyme_2_hgnc_id:
HGNC:6480

# Metabolic_Enzyme_2_PDB_ID:
1HML

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_2_Gene_Sequence:
>429 bp
ATGAGGTTCTTTGTCCCTCTGTTCCTGGTGGGCATCCTGTTCCCTGCCATCCTGGCCAAG
CAATTCACAAAATGTGAGCTGTCCCAGCTGCTGAAAGACATAGATGGTTATGGAGGCATC
GCTTTGCCTGAATTGATCTGTACCATGTTTCACACCAGTGGTTATGACACACAAGCCATA
GTTGAAAACAATGAAAGCACGGAATATGGACTCTTCCAGATCAGTAATAAGCTTTGGTGC
AAGAGCAGCCAGGTCCCTCAGTCAAGGAACATCTGTGACATCTCCTGTGACAAGTTCCTG
GATGATGACATTACTGATGACATAATGTGTGCCAAGAAGATCCTGGATATTAAAGGAATT
GACTACTGGTTGGCCCATAAAGCCCTCTGCACTGAGAAGCTGGAACAGTGGCTTTGTGAG
AAGTTGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
J00270

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_2_Locus:
12q13

# Metabolic_Enzyme_2_SNPs:
rs2232565; rs2232566; rs2071380; rs2232569; rs2232570; rs2731088; rs2705170; rs2409044; rs12582811; rs11168643; rs11168642; rs3759149; rs10875835; rs4439559; rs2232567; rs2232568; rs35237195; rs34192861; rs10696670; rs34861458; rs12372110; rs7315024; rs35399476; rs35014829; rs10747550; rs10875833; rs10875834; rs11168635; rs11168636; rs11168637; rs11168638; rs11168639; rs11168640; rs11168641; rs11168644; rs12317119; rs12580814; rs17237094; rs17237198; rs17834022; rs1807757; rs1863543; rs1895997; rs1895998; rs1895999; rs2114321; rs2114322; rs2162318; rs2194984; rs2555002; rs2555003; rs2705117; rs7306166; rs7312017

# Metabolic_Enzyme_2_General_References:
6285305; 2954544; 5049057; 1920433; 8366079; 9537992; 10080897

# Metabolic_Enzyme_2_References:
14627739; 15134431; 15215482; 15659367

# Metabolic_Enzyme_3_ID:
7584

# Metabolic_Enzyme_3_Name:
Leukocyte elastase precursor

# Metabolic_Enzyme_3_Synonyms:
Elastase-2; Neutrophil elastase; PMN elastase; Bone marrow serine protease; Medullasin; Human leukocyte elastase; HLE

# Metabolic_Enzyme_3_Gene_Name:
ELA2

# Metabolic_Enzyme_3_Protein_Sequence:
>Leukocyte elastase precursor
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH

# Metabolic_Enzyme_3_Number_of_Residues:
267

# Metabolic_Enzyme_3_Molecular_Weight:
28518

# Metabolic_Enzyme_3_Theoretical_pI:
9.41

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis

# Metabolic_Enzyme_3_Pathway:
Not Available

# Metabolic_Enzyme_3_Reaction:
Hydrolysis of proteins, including elastin. Preferential cleavage Val-|- > Ala-|-

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00089:Trypsin

# Metabolic_Enzyme_3_Signals:
1-27

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.4.21.37

# Metabolic_Enzyme_3_GenBank_ID_Protein:
296665

# Metabolic_Enzyme_3_SwissProt_ID:
ELNE_HUMAN (P08246)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ELA2

# Metabolic_Enzyme_3_Geneatlas_id:
ELA2

# Metabolic_Enzyme_3_hgnc_id:
HGNC:3309

# Metabolic_Enzyme_3_PDB_ID:
1H1B

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_3_Gene_Sequence:
>804 bp
ATGACCCTCGGCCGCCGACTCGCGTGTCTTTTCCTCGCCTGTGTCCTGCCGGCCTTGCTG
CTGGGGGGCACCGCGCTGGCCTCGGAGATTGTGGGGGGCCGGCGAGCGCGGCCCCACGCG
TGGCCCTTCATGGTGTCCCTGCAGCTGCGCGGAGGCCACTTCTGCGGCGCCACCCTGATT
GCGCCCAACTTCGTCATGTCGGCCGCGCACTGCGTGGCGAATGTAAACGTCCGCGCGGTG
CGGGTGGTCCTGGGAGCCCATAACCTCTCGCGGCGGGAGCCCACCCGGCAGGTGTTCGCC
GTGCAGCGCATCTTCGAAAACGGCTACGACCCCGTAAACTTGCTCAACGACATCGTGATT
CTCCAGCTCAACGGGTCGGCCACCATCAACGCCAACGTGCAGGTGGCCCAGCTGCCGGCT
CAGGGACGCCGCCTGGGCAACGGGGTGCAGTGCCTGGCCATGGGCTGGGGCCTTCTGGGC
AGGAACCGTGGGATCGCCAGCGTCCTGCAGGAGCTCAACGTGACGGTGGTGACGTCCCTC
TGCCGTCGCAGCAACGTCTGCACTCTCGTGAGGGGCCGGCAGGCCGGCGTCTGTTTCGGG
GACTCCGGCAGCCCCTTGGTCTGCAACGGGCTAATCCACGGAATTGCCTCCTTCGTCCGG
GGAGGCTGCGCCTCAGGGCTCTACCCCGATGCCTTTGCCCCGGTGGCACAGTTTGTAAAC
TGGATCGACTCTATCATCCAACGCTCCGAGGACAACCCCTGTCCCCACCCCCGGGACCCG
GACCCGGCCAGCAGGACCCACTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
Y00477

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_3_Locus:
19p13.3

# Metabolic_Enzyme_3_SNPs:
rs17216656; rs17223045; rs17216649; rs8111201; rs17223038; rs7250194; rs8106265; rs8111657; rs17216621; rs740021; rs3761005; rs6510983; rs3761001; rs10409474; rs3761006; rs351107; rs2007647; rs17216550; rs7254054; rs3761007; rs3761003; rs17223066; rs7260160; rs10421849; rs17216579; rs17222989; rs17216614; rs3729656; rs17216593; rs17216670; rs17216663; rs28931611; rs17216628; rs17222996; rs17223003; rs17223024; rs17216642; rs657027; rs17216635; rs17223017; rs1683578; rs351105; rs34535016; rs191587; rs17223010; rs10413889; rs17216684; rs17223052; rs3834646; rs17216677; rs17216607; rs17222975; rs3761002; rs10416435; rs17216586; rs17223073; rs351106; rs17216691; rs3761004; rs17216699; rs17216558; rs10407069; rs1006343; rs10407668; rs10414837; rs1042282; rs1042284; rs10424211; rs11882455; rs12985692; rs12985970; rs1651895; rs1651896; rs1651897; rs1683561; rs1683562; rs1683563; rs1683564; rs17684161; rs2230216; rs351111; rs351112; rs35186399; rs3761008; rs3826945; rs3826946; rs4807931; rs629631; rs631822; rs7257699; rs8953

# Metabolic_Enzyme_3_General_References:
3479752; 2902087; 2775493; 2322278; 2822677; 3550808; 2501794; 3422232; 2462434; 1859409; 2911584; 3391280; 3640709; 10581030

# Metabolic_Enzyme_3_References:
12918024; 15454291

# Macromolecular_Interacting_Partner_1_ID:
5548

# Macromolecular_Interacting_Partner_1_Name:
Acyl-CoA desaturase

# Macromolecular_Interacting_Partner_1_Synonyms:
Stearoyl-CoA desaturase; Fatty acid desaturase; Delta(9-desaturase

# Macromolecular_Interacting_Partner_1_Gene_Name:
SCD

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>AcylCoA desaturase
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVE
YVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGA
HRLWSHRSYKARLPLRLFLII
ANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFF
FSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKL
VMFQRRYYKPGLLMMCFILPTLVPWYF
WGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNI
SPRENILVSLGAVGEG
FHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKR
TGDGN
YKSG

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
359

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
41523

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
9.28

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  CoA desaturase activity
Function:  stearoyl-CoA 9-desaturase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
 ||
>>>
Process:  fatty acid desaturation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  organic acid metabolism
Process:  carboxylic acid metabolism
Process:  fatty acid metabolism
Process:  fatty acid biosynthesis
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  endoplasmic reticulum
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Energy production and conversion 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00487:FA_desaturase

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
76-96
98-118
223-243
315-335

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 1.14.19.1

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
2190404

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
ACOD_HUMAN (O00767)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
SCD

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
SCD

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:10571

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein (Probable)

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1080 bp

ATGCCGGCCCACTTGCTGCAGGACGATATCTCTAGCTCCTATACCACCACCACCACCAT
TACAGCGCCTC
CTCCAGGGGTCCTGCAGAATGGAGGAGATAAGTTGGAGACGATGCCCC
TCTACTTGGAAGACGACATTCG
CCCTGATATAAAAGATGATATATATGACCCCACCTAC
AAGGATAAGGAAGGCCCAAGCCCCAAGGTTGAA
TATGTCTGGAGAAACATCATCCTTAT
GTCTCTGCTACACTTGGGAGCCCTGTATGGGATCACTTTGATTC
CTACCTGCAAGTTCT
ACACCTGGCTTTGGGGGGTATTCTACTATTTTGTCAGTGCCCTGGGCATAACAGC
AGGA
GCTCATCGTCTGTGGAGCCACCGCTCTTACAAAGCTCGGCTGCCCCTACGGCTCTTTCTG
ATCATT
GCCAACACAATGGCATTCCAGAATGATGTCTATGAATGGGCTCGTGACCACCG
TGCCCACCACAAGTTTT
CAGAAACACATGCTGATCCTCATAATTCCCGACGTGGCTTTT
TCTTCTCTCACGTGGGTTGGCTGCTTGT
GCGCAAACACCCAGCTGTCAAAGAGAAGGGG
AGTACGCTAGACTTGTCTGACCTAGAAGCTGAGAAACTG
GTGATGTTCCAGAGGAGGTA
CTACAAACCTGGCTTGCTGATGATGTGCTTCATCCTGCCCACGCTTGTGC
CCTGGTATT
TCTGGGGTGAAACTTTTCAAAACAGTGTGTTCGTTGCCACTTTCTTGCGATATGCTGTGG
T
GCTTAATGCCACCTGGCTGGTGAACAGTGCTGCCCACCTCTTCGGATATCGTCCTTAT
GACAAGAACATT
AGCCCCCGGGAGAATATCCTGGTTTCACTTGGAGCTGTGGGTGAGGG
CTTCCACAACTACCACCACTCCT
TTCCCTATGACTACTCTGCCAGTGAGTACCGCTGGC
ACATCAACTTCAACACATTCTTCATTGATTGGAT
GGCCGCCCTCGGTCTGACCTATGAC
CGGAAGAAAGTCTCCAAGGCCGCCATCTTGGCCAGGATTAAAAGA
ACCGGAGATGGAAA
CTACAAGAGTGGCTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
Y13647

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_1_Locus:
10q23-q24

# Macromolecular_Interacting_Partner_1_SNPs:
rs2234970; rs560792; rs7849; rs3978768; rs11557927; rs1054411; rs11557934; rs10883465; rs674179; rs11812482; rs15950; rs1056901; rs17113180; rs1502593; rs3071; rs641996; rs522951; rs3793767; rs529271; rs639060; rs599961; rs3870747; rs3793766; rs612472; rs3793768; rs7904902; rs10883463; rs681278; rs12247426; rs640773; rs631315; rs11190481; rs10883464; rs12241153; rs11190484; rs11190483; rs3829160; rs3750714; rs11190480; rs12571042; rs3793769; rs3793765; rs11190485; rs508384; rs670213; rs2275657; rs2275656; rs11599710; rs2167444; rs658673; rs35602244; rs1054412; rs11835; rs2182351; rs11557931; rs3178760; rs11557929; rs479875; rs11557930; rs11557932; rs11557933; rs41290540; rs11557928; rs15019; rs11557936; rs34341900; rs2027450; rs12245399; rs34243830; rs36033368; rs7895764; rs12253685; rs3842637; rs34681780; rs34654961; rs599189; rs11446562; rs11381871; rs35810382; rs35216666; rs34046512; rs34140560; rs11442953; rs11392822; rs3793770; rs35398696; rs12780455; rs3838759; rs10523737; rs11190482; rs12780212; rs11383077; rs12253255; rs682217; rs35307910; rs35017485; rs12782060; rs12218077; rs5787383; rs35119663; rs33931142; rs683959; rs686884; rs11190479; rs35871583; rs12247381; rs683957; rs36110241; rs36045940; rs11190478; rs11190487; rs11190488; rs11190489; rs11190490; rs1393491; rs1393492; rs17113027; rs17669878; rs1910216; rs2060792; rs2862987; rs3961637; rs490726; rs539480; rs569184; rs569910; rs570844; rs608622; rs655120; rs667910; rs683854; rs7068875; rs7081803; rs735877

# Macromolecular_Interacting_Partner_1_General_References:
10229681; 11415448; 7909540

# Macromolecular_Interacting_Partner_1_References:
12840656; 14977874; 15066988; 15702387

# Macromolecular_Interacting_Partner_2_ID:
7515

# Macromolecular_Interacting_Partner_2_Name:
Free fatty acid receptor 1

# Macromolecular_Interacting_Partner_2_Synonyms:
G-protein coupled receptor 40

# Macromolecular_Interacting_Partner_2_Gene_Name:
FFAR1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Free fatty acid receptor 1
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLP
LKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRP
CYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAG
PARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPY
NASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK


# Macromolecular_Interacting_Partner_2_Number_of_Residues:
300

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
31457

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
9.75

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G- proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_2_Signals:
1-19

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
2612946

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
FFAR1_HUMAN (O14842)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
FFAR1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
FFAR1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:4498

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>903 bp
ATGGACCTGCCCCCGCAGCTCTCCTTCGGCCTCTATGTGGCCGCCTTTGCGCTGGGCTTC
CCGCTCAACGTCCTGGCCATCCGAGGCGCGACGGCCCACGCCCGGCTCCGTCTCACCCCT
AGCCTGGTCTACGCCCTGAACCTGGGCTGCTCCGACCTGCTGCTGACAGTCTCTCTGCCC
CTGAAGGCGGTGGAGGCGCTAGCCTCCGGGGCCTGGCCTCTGCCGGCCTCGCTGTGCCCC
GTCTTCGCGGTGGCCCACTTCTTCCCACTCTATGCCGGCGGGGGCTTCCTGGCCGCCCTG
AGTGCAGGCCGCTACCTGGGAGCAGCCTTCCCCTTGGGCTACCAAGCCTTCCGGAGGCCG
TGCTATTCCTGGGGGGTGTGCGCGGCCATCTGGGCCCTCGTCCTGTGTCACCTGGGTCTG
GTCTTTGGGTTGGAGGCTCCAGGAGGCTGGCTGGACCACAGCAACACCTCCCTGGGCATC
AACACACCGGTCAACGGCTCTCCGGTCTGCCTGGAGGCCTGGGACCCGGCCTCTGCCGGC
CCGGCCCGCTTCAGCCTCTCTCTCCTGCTCTTTTTTCTGCCCTTGGCCATCACAGCCTTC
TGCTACGTGGGCTGCCTCCGGGCACTGGCCCGCTCCGGCCTGACGCACAGGCGGAAGCTG
CGGGCCGCCTGGGTGGCCGGCGGGGCCCTCCTCACGCTGCTGCTCTGCGTAGGACCCTAC
AACGCCTCCAACGTGGCCAGCTTCCTGTACCCCAATCTAGGAGGCTCCTGGCGGAAGCTG
GGGCTCATCACGGGTGCCTGGAGTGTGGTGCTTAATCCGCTGGTGACCGGTTACTTGGGA
AGGGGTCCTGGCCTGAAGACAGTGTGTGCGGCAAGAACGCAAGGGGGCAAGTCCCAGAAG
TAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AF024687

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_2_Locus:
19q13.1

# Macromolecular_Interacting_Partner_2_SNPs:
rs2301151; rs1978013; rs1573611; rs16970264; rs10418569; rs17719343; rs1978014; rs35289185; rs28495605; rs35923096; rs41275830; rs34141661; rs41275832; rs35991891; rs34359218; rs35036122; rs10406069; rs10406539; rs10413500; rs10413526; rs10423648; rs10426830; rs1058406; rs1058407; rs12459138; rs12462800; rs12975589; rs12984835; rs12985354; rs17272288; rs17719289; rs2156930; rs2312585; rs2312586; rs3088063; rs34826052; rs3746250; rs3746251; rs387083; rs417030; rs4805119; rs4805120; rs4805121; rs4806131; rs7259477; rs756901; rs756902; rs756903; rs8108571

# Macromolecular_Interacting_Partner_2_General_References:
9344866; 12496284

# Macromolecular_Interacting_Partner_2_References:
15695516; 15914509

# Macromolecular_Interacting_Partner_3_ID:
7549

# Macromolecular_Interacting_Partner_3_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
INS

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_3_Signals:
1-24

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
INS

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11p15.5

# Macromolecular_Interacting_Partner_3_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_3_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_3_References:
12643112; 12656670; 12829627; 14713277

# Macromolecular_Interacting_Partner_4_ID:
7551

# Macromolecular_Interacting_Partner_4_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_4_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_4_Locus:
6p21.3

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_4_References:
15763380; 15952594

# Macromolecular_Interacting_Partner_5_ID:
7556

# Macromolecular_Interacting_Partner_5_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_5_Signals:
1-18

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_5_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_5_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_5_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_5_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_5_References:
12454271; 12743438; 12790799; 14970200

# Macromolecular_Interacting_Partner_6_ID:
7562

# Macromolecular_Interacting_Partner_6_Name:
Apolipoprotein B-100 precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
Apo B-100[Contains: Apolipoprotein B-48; Apo B-48]

# Macromolecular_Interacting_Partner_6_Gene_Name:
APOB

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Apolipoprotein B100 precursor
MDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAES
SSGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSE
EFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLFLD
TVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLIS
SSQSCQYTLDAKRKHVAEAICKEQHLFLPFSYNNKYGMVAQVTQTLKLEDTPKINSRFFG
EGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGLSD
EAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPE
PSAQQLREIFNMARDQRSRATLYALSHAVNNYHKTNPTGTQELLDIANYLMEQIQDDCTG
DEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKDKD
QEVLLQTFLDDASPGDKRLAAYLMLMRSPSQADINKIVQILPWEQNEQVKNFVASHIANI
LNSEELDIQDLKKLVKEALKESQLPTVMDFRKFSRNYQLYKSVSLPSLDPASAKIEGNLI
FDPNNYLPKESMLKTTLTAFGFASADLIEIGLEGKGFEPTLEALFGKQGFFPDSVNKALY
WVNGQVPDGVSKVLVDHFGYTKDDKHEQDMVNGIMLSVEKLIKDLKSKEVPEARAYLRIL
GEELGFASLHDLQLLGKLLLMGARTLQGIPQMIGEVIRKGSKNDFFLHYIFMENAFELPT
GAGLQLQISSSGVIAPGAKAGVKLEVANMQAELVAKPSVSVEFVTNMGIIIPDFARSGVQ
MNTNFFHESGLEAHVALKAGKLKFIIPSPKRPVKLLSGGNTLHLVSTTKTEVIPPLIENR
QSWSVCKQVFPGLNYCTSGAYSNASSTDSASYYPLTGDTRLELELRPTGEIEQYSVSATY
ELQREDRALVDTLKFVTQAEGAKQTEATMTFKYNRQSMTLSSEVQIPDFDVDLGTILRVN
DESTEGKTSYRLTLDIQNKKITEVALMGHLSCDTKEERKIKGVISIPRLQAEARSEILAH
WSPAKLLLQMDSSATAYGSTVSKRVAWHYDEEKIEFEWNTGTNVDTKKMTSNFPVDLSDY
PKSLHMYANRLLDHRVPETDMTFRHVGSKLIVAMSSWLQKASGSLPYTQTLQDHLNSLKE
FNLQNMGLPDFHIPENLFLKSDGRVKYTLNKNSLKIEIPLPFGGKSSRDLKMLETVRTPA
LHFKSVGFHLPSREFQVPTFTIPKLYQLQVPLLGVLDLSTNVYSNLYNWSASYSGGNTST
DHFSLRARYHMKADSVVDLLSYNVQGSGETTYDHKNTFTLSCDGSLRHKFLDSNIKFSHV
EKLGNNPVSKGLLIFDASSSWGPQMSASVHLDSKKKQHLFVKEVKIDGQFRVSSFYAKGT
YGLSCQRDPNTGRLNGESNLRFNSSYLQGTNQITGRYEDGTLSLTSTSDLQSGIIKNTAS
LKYENYELTLKSDTNGKYKNFATSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLN
SHGLELNADILGTDKINSGAHKATLRIGQDGISTSATTNLKCSLLVLENELNAELGLSGA
SMKLTTNGRFREHNAKFSLDGKAALTELSLGSAYQAMILGVDSKNIFNFKVSQEGLKLSN
DMMGSYAEMKFDHTNSLNIAGLSLDFSSKLDNIYSSDKFYKQTVNLQLQPYSLVTTLNSD
LKYNALDLTNNGKLRLEPLKLHVAGNLKGAYQNNEIKHIYAISSAALSASYKADTVAKVQ
GVEFSHRLNTDIAGLASAIDMSTNYNSDSLHFSNVFRSVMAPFTMTIDAHTNGNGKLALW
GEHTGQLYSKFLLKAEPLAFTFSHDYKGSTSHHLVSRKSISAALEHKVSALLTPAEQTGT
WKLKTQFNNNEYSQDLDAYNTKDKIGVELTGRTLADLTLLDSPIKVPLLLSEPINIIDAL
EMRDAVEKPQEFTIVAFVKYDKNQDVHSINLPFFETLQEYFERNRQTIIVVVENVQRNLK
HINIDQFVRKYRAALGKLPQQANDYLNSFNWERQVSHAKEKLTALTKKYRITENDIQIAL
DDAKINFNEKLSQLQTYMIQFDQYIKDSYDLHDLKIAIANIIDEIIEKLKSLDEHYHIRV
NLVKTIHDLHLFIENIDFNKSGSSTASWIQNVDTKYQIRIQIQEKLQQLKRHIQNIDIQH
LAGKLKQHIEAIDVRVLLDQLGTTISFERINDVLEHVKHFVINLIGDFEVAEKINAFRAK
VHELIERYEVDQQIQVLMDKLVELTHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDA
VKKLNELSFKTFIEDVNKFLDMLIKKLKSFDYHQFVDETNDKIREVTQRLNGEIQALELP
QKAEALKLFLEETKATVAVYLESLQDTKITLIINWLQEALSSASLAHMKAKFRETLEDTR
DRMYQMDIQQELQRYLSLVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRMKAL
VEQGFTVPEIKTILGTMPAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKDLKNIK
IPSRFSTPEFTILNTFHIPSFTIDFVEMKVKIIRTIDQMQNSELQWPVPDIYLRDLKVED
IPLARITLPDFRLPEIAIPEFIIPTLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYS
ILKIQSPLFTLDANADIGNGTTSANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKIN
PLALKESVKFSSKYLRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNGVIVKINNQ
LTLDSNTKYFHKLNIPKLDFSSQADLRNEIKTLLKAGHIAWTSSGKGSWKWACPRFSDEG
THESQISFTIEGPLTSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHS
VLTAKGMALFGEGKAEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVRF
PLRLTGKIDFLNNYALFLSPSAQQASWQVSARFNQYKYNQNFSAGNNENIMEAHVGINGE
ANLDFLNIPLTIPEMRLPYTIITTPPLKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKN
KHRHSITNPLAVLCEFISQSIKSFDRHFEKNRNNALDFVTKSYNETKIKFDKYKAEKSHD
ELPRTFQIPGYTVPVVNVEVSPFTIEMSAFGYVFPKAVSMPSFSILGSDVRVPSYTLILP
SLELPVLHVPRNLKLSLPHFKELCTISHIFIPAMGNITYDFSFKSSVITLNTNAELFNQS
DIVAHLLSSSSSVIDALQYKLEGTTRLTRKRGLKLATALSLSNKFVEGSHNSTVSLTTKN
MEVSVAKTTKAEIPILRMNFKQELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVDHK
LSLESLTSYFSIESSTKGDVKGSVLSREYSGTIASEANTYLNSKSTRSSVKLQGTSKIDD
IWNLEVKENFAGEATLQRIYSLWEHSTKNHLQLEGLFFTNGEHTSKATLELSPWQMSALV
QVHASQPSSFHDFPDLGQEVALNANTKNQKIRWKNEVRIHSGSFQSQVELSNDQEKAHLD
IAGSLEGHLRFLKNIILPVYDKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPNGYSFS
IPVKVLADKFITPGLKLNDLNSVLVMPTFHVPFTDLQVPSCKLDFREIQIYKKLRTSSFA
LNLPTLPEVKFPEVDVLTKYSQPEDSLIPFFEITVPESQLTVSQFTLPKSVSDGIAALDL
NAVANKIADFELPTIIVPEQTIEIPSIKFSVPAGIVIPSFQALTARFEVDSPVYNATWSA
SLKNKADYVETVLDSTCSSTVQFLEYELNVLGTHKIEDGTLASKTKGTLAHRDFSAEYEE
DGKFEGLQEWEGKAHLNIKSPAFTDLHLRYQKDKKGISTSAASPAVGTVGMDMDEDDDFS
KWNFYYSPQSSPDKKLTIFKTELRVRESDEETQIKVNWEEEAASGLLTSLKDNVPKATGV
LYDYVNKYHWEHTGLTLREVSSKLRRNLQNNAEWVYQGAIRQIDDIDVRFQKAASGTTGT
YQEWKDKAQNLYQELLTQEGQASFQGLKDNVFDGLVRVTQKFHMKVKHLIDSLIDFLNFP
RFQFPGKPGIYTREELCTMFIREVGTVLSQVYSKVHNGSEILFSYFQDLVITLPFELRKH
KLIDVISMYRELLKDLSKEAQEVFKAIQSLKTTEVLRNLQDLLQFIFQLIEDNIKQLKEM
KFTYLINYIQDEINTIFNDYIPYVFKLLKENLCLNLHKFNEFIQNELQEASQELQQIHQY
IMALREEYFDPSIVGWTVKYYELEEKIVSLIKNLLVALKDFHSEYIVSASNFTSQLSSQV
EQFLHRNIQEYLSILTDPDGKGKEKIAELSATAQEIIKSQAIATKKIISDYHQQFRYKLQ
DFSDQLSDYYEKFIAESKRLIDLSIQNYHTFLIYITELLKKLQSTTVMNPYMKLAPGELT
IIL

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
4563

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
515568

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
7.06

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  transporter activity
Function:  lipid transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  lipid transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Replication, recombination and repair 

# Macromolecular_Interacting_Partner_6_Specific_Function:
Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF06448:DUF1081;
PF09172:DUF1943;
PF01347:Vitellogenin_N

# Macromolecular_Interacting_Partner_6_Signals:
1-27

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
34331

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
APOB_HUMAN (P04114)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
APOB

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
APOB

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:603

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>13692 bp
ATGGACCCGCCGAGGCCCGCGCTGCTGGCGCTGCTGGCGCTGCCTGCGCTGCTGCTGCTG
CTGCTGGCGGGCGCCAGGGCCGAAGAGGAAATGCTGGAAAATGTCAGCCTGGTCTGTCCA
AAAGATGCGACCCGATTCAAGCACCTCCGGAAGTACACATACAACTATGAGGCTGAGAGT
TCCAGTGGAGTCCCTGGGACTGCTGATTCAAGAAGTGCCACCAGGATCAACTGCAAGGTT
GAGCTGGAGGTTCCCCAGCTCTGCAGCTTCATCCTGAAGACCAGCCAGTGCACCCTGAAA
GAGGTGTATGGCTTCAACCCTGAGGGCAAAGCCTTGCTGAAGAAAACCAAGAACTCTGAG
GAGTTTGCTGCAGCCATGTCCAGGTATGAGCTCAAGCTGGCCATTCCAGAAGGGAAGCAG
GTTTTCCTTTACCCGGAGAAAGATGAACCTACTTACATCCTGAACATCAAGAGGGGCATC
ATTTCTGCCCTCCTGGTTCCCCCAGAGACAGAAGAAGCCAAGCAAGTGTTGTTTCTGGAT
ACCGTGTATGGAAACTGCTCCACTCACTTTACCGTCAAGACGAGGAAGGGCAATGTGGCA
ACAGAAATATCCACTGAAAGAGACCTGGGGCAGTGTGATCGCTTCAAGCCCATCCGCACA
GGCATCAGCCCACTTGCTCTCATCAAAGGCATGACCCGCCCCTTGTCAACTCTGATCAGC
AGCAGCCAGTCCTGTCAGTACACACTGGACGCTAAGAGGAAGCATGTGGCAGAAGCCATC
TGCAAGGAGCAACACCTCTTCCTGCCTTTCTCCTACAACAATAAGTATGGGATGGTAGCA
CAAGTGACACAGACTTTGAAACTTGAAGACACACCAAAGATCAACAGCCGCTTCTTTGGT
GAAGGTACTAAGAAGATGGGCCTCGCATTTGAGAGCACCAAATCCACATCACCTCCAAAG
CAGGCCGAAGCTGTTTTGAAGACTCTCCAGGAACTGAAAAAACTAACCATCTCTGAGCAA
AATATCCAGAGAGCTAATCTCTTCAATAAGCTGGTTACTGAGCTGAGAGGCCTCAGTGAT
GAAGCAGTCACATCTCTCTTGCCACAGCTGATTGAGGTGTCCAGCCCCATCACTTTACAA
GCCTTGGTTCAGTGTGGACAGCCTCAGTGCTCCACTCACATCCTCCAGTGGCTGAAACGT
GTGCATGCCAACCCCCTTCTGATAGATGTGGTCACCTACCTGGTGGCCCTGATCCCCGAG
CCCTCAGCACAGCAGCTGCGAGAGATCTTCAACATGGCGAGGGATCAGCGCAGCCGAGCC
ACCTTGTATGCGCTGAGCCACGCGGTCAACAACTATCATAAGACAAACCCTACAGGGACC
CAGGAGCTGCTGGACATTGCTAATTACCTGATGGAACAGATTCAAGATGACTGCACTGGG
GATGAAGATTACACCTATTTGATTCTGCGGGTCATTGGAAATATGGGCCAAACCATGGAG
CAGTTAACTCCAGAACTCAAGTCTTCAATCCTCAAATGTGTCCAAAGTACAAAGCCATCA
CTGATGATCCAGAAAGCTGCCATCCAGGCTCTGCGGAAAATGGAGCCTAAAGACAAGGAC
CAGGAGGTTCTTCTTCAGACTTTCCTTGATGATGCTTCTCCGGGAGATAAGCGACTGGCT
GCCTATCTTATGTTGATGAGGAGTCCTTCACAGGCAGATATTAACAAAATTGTCCAAATT
CTACCATGGGAACAGAATGAGCAAGTGAAGAACTTTGTGGCTTCCCATATTGCCAATATC
TTGAACTCAGAAGAATTGGATATCCAAGATCTGAAAAAGTTAGTGAAAGAAGCTCTGAAA
GAATCTCAACTTCCAACTGTCATGGACTTCAGAAAATTCTCTCGGAACTATCAACTCTAC
AAATCTGTTTCTCTTCCATCACTTGACCCAGCCTCAGCCAAAATAGAAGGGAATCTTATA
TTTGATCCAAATAACTACCTTCCTAAAGAAAGCATGCTGAAAACTACCCTCACTGCCTTT
GGATTTGCTTCAGCTGACCTCATCGAGATTGGCTTGGAAGGAAAAGGCTTTGAGCCAACA
TTGGAAGCTCTTTTTGGGAAGCAAGGATTTTTCCCAGACAGTGTCAACAAAGCTTTGTAC
TGGGTTAATGGTCAAGTTCCTGATGGTGTCTCTAAGGTCTTAGTGGACCACTTTGGCTAT
ACCAAAGATGATAAACATGAGCAGGATATGGTAAATGGAATAATGCTCAGTGTTGAGAAG
CTGATTAAAGATTTGAAATCCAAAGAAGTCCCGGAAGCCAGAGCCTACCTCCGCATCTTG
GGAGAGGAGCTTGGTTTTGCCAGTCTCCATGACCTCCAGCTCCTGGGAAAGCTGCTTCTG
ATGGGTGCCCGCACTCTGCAGGGGATCCCCCAGATGATTGGAGAGGTCATCAGGAAGGGC
TCAAAGAATGACTTTTTTCTTCACTACATCTTCATGGAGAATGCCTTTGAACTCCCCACT
GGAGCTGGATTACAGTTGCAAATATCTTCATCTGGAGTCATTGCTCCCGGAGCCAAGGCT
GGAGTAAAACTGGAAGTAGCCAACATGCAGGCTGAACTGGTGGCAAAACCCTCCGTGTCT
GTGGAGTTTGTGACAAATATGGGCATCATCATTCCGGACTTCGCTAGGAGTGGGGTCCAG
ATGAACACCAACTTCTTCCACGAGTCGGGTCTGGAGGCTCATGTTGCCCTAAAAGCTGGG
AAGCTGAAGTTTATCATTCCTTCCCCAAAGAGACCAGTCAAGCTGCTCAGTGGAGGCAAC
ACATTACATTTGGTCTCTACCACCAAAACGGAGGTGATCCCACCTCTCATTGAGAACAGG
CAGTCCTGGTCAGTTTGCAAGCAAGTCTTTCCTGGCCTGAATTACTGCACCTCAGGCGCT
TACTCCAACGCCAGCTCCACAGACTCCGCCTCCTACTATCCGCTGACCGGGGACACCAGA
TTAGAGCTGGAACTGAGGCCTACAGGAGAGATTGAGCAGTATTCTGTCAGCGCAACCTAT
GAGCTCCAGAGAGAGGACAGAGCCTTGGTGGATACCCTGAAGTTTGTAACTCAAGCAGAA
GGTGCGAAGCAGACTGAGGCTACCATGACATTCAAATATAATCGGCAGAGTATGACCTTG
TCCAGTGAAGTCCAAATTCCGGATTTTGATGTTGACCTCGGAACAATCCTCAGAGTTAAT
GATGAATCTACTGAGGGCAAAACGTCTTACAGACTCACCCTGGACATTCAGAACAAGAAA
ATTACTGAGGTCGCCCTCATGGGCCACCTAAGTTGTGACACAAAGGAAGAAAGAAAAATC
AAGGGTGTTATTTCCATACCCCGTTTGCAAGCAGAAGCCAGAAGTGAGATCCTCGCCCAC
TGGTCGCCTGCCAAACTGCTTCTCCAAATGGACTCATCTGCTACAGCTTATGGCTCCACA
GTTTCCAAGAGGGTGGCATGGCATTATGATGAAGAGAAGATTGAATTTGAATGGAACACA
GGCACCAATGTAGATACCAAAAAAATGACTTCCAATTTCCCTGTGGATCTCTCCGATTAT
CCTAAGAGCTTGCATATGTATGCTAATAGACTCCTGGATCACAGAGTCCCTGAAACAGAC
ATGACTTTCCGGCACGTGGGTTCCAAATTAATAGTTGCAATGAGCTCATGGCTTCAGAAG
GCATCTGGGAGTCTTCCTTATACCCAGACTTTGCAAGACCACCTCAATAGCCTGAAGGAG
TTCAACCTCCAGAACATGGGATTGCCAGACTTCCACATCCCAGAAAACCTCTTCTTAAAA
AGCGATGGCCGGGTCAAATATACCTTGAACAAGAACAGTTTGAAAATTGAGATTCCTTTG
CCTTTTGGTGGCAAATCCTCCAGAGATCTAAAGATGTTAGAGACTGTTAGGACACCAGCC
CTCCACTTCAAGTCTGTGGGATTCCATCTGCCATCTCGAGAGTTCCAAGTCCCTACTTTT
ACCATTCCCAAGTTGTATCAACTGCAAGTGCCTCTCCTGGGTGTTCTAGACCTCTCCACG
AATGTCTACAGCAACTTGTACAACTGGTCCGCCTCCTACAGTGGTGGCAACACCAGCACA
GACCATTTCAGCCTTCGGGCTCGTTACCACATGAAGGCTGACTCTGTGGTTGACCTGCTT
TCCTACAATGTGCAAGGATCTGGAGAAACAACATATGACCACAAGAATACGTTCACACTA
TCATGTGATGGGTCTCTACGCCACAAATTTCTAGATTCGAATATCAAATTCAGTCATGTA
GAAAAACTTGGAAACAACCCAGTCTCAAAAGGTTTACTAATATTCGATGCATCTAGTTCC
TGGGGACCACAGATGTCTGCTTCAGTTCATTTGGACTCCAAAAAGAAACAGCATTTGTTT
GTCAAAGAAGTCAAGATTGATGGGCAGTTCAGAGTCTCTTCGTTCTATGCTAAAGGCACA
TATGGCCTGTCTTGTCAGAGGGATCCTAACACTGGCCGGCTCAATGGAGAGTCCAACCTG
AGGTTTAACTCCTCCTACCTCCAAGGCACCAACCAGATAACAGGAAGATATGAAGATGGA
ACCCTCTCCCTCACCTCCACCTCTGATCTGCAAAGTGGCATCATTAAAAATACTGCTTCC
CTAAAGTATGAGAACTACGAGCTGACTTTAAAATCTGACACCAATGGGAAGTATAAGAAC
TTTGCCACTTCTAACAAGATGGATATGACCTTCTCTAAGCAAAATGCACTGCTGCGTTCT
GAATATCAGGCTGATTACGAGTCATTGAGGTTCTTCAGCCTGCTTTCTGGATCACTAAAT
TCCCATGGTCTTGAGTTAAATGCTGACATCTTAGGCACTGACAAAATTAATAGTGGTGCT
CACAAGGCGACACTAAGGATTGGCCAAGATGGAATATCTACCAGTGCAACGACCAACTTG
AAGTGTAGTCTCCTGGTGCTGGAGAATGAGCTGAATGCAGAGCTTGGCCTCTCTGGGGCA
TCTATGAAATTAACAACAAATGGCCGCTTCAGGGAACACAATGCAAAATTCAGTCTGGAT
GGGAAAGCCGCCCTCACAGAGCTATCACTGGGAAGTGCTTATCAGGCCATGATTCTGGGT
GTCGACAGCAAAAACATTTTCAACTTCAAGGTCAGTCAAGAAGGACTTAAGCTCTCAAAT
GACATGATGGGCTCATATGCTGAAATGAAATTTGACCACACAAACAGTCTGAACATTGCA
GGCTTATCACTGGACTTCTCTTCAAAACTTGACAACATTTACAGCTCTGACAAGTTTTAT
AAGCAAACTGTTAATTTACAGCTACAGCCCTATTCTCTGGTAACTACTTTAAACAGTGAC
CTGAAATACAATGCTCTGGATCTCACCAACAATGGGAAACTACGGCTAGAACCCCTGAAG
CTGCATGTGGCTGGTAACCTAAAAGGAGCCTACCAAAATAATGAAATAAAACACATCTAT
GCCATCTCTTCTGCTGCCTTATCAGCAAGCTATAAAGCAGACACTGTTGCTAAGGTTCAG
GGTGTGGAGTTTAGCCATCGGCTCAACACAGACATCGCTGGGCTGGCTTCAGCCATTGAC
ATGAGCACAAACTATAATTCAGACTCACTGCATTTCAGCAATGTCTTCCGTTCTGTAATG
GCCCCGTTTACCATGACCATCGATGCACATACAAATGGCAATGGGAAACTCGCTCTCTGG
GGAGAACATACTGGGCAGCTGTATAGCAAATTCCTGTTGAAAGCAGAACCTCTGGCATTT
ACTTTCTCTCATGATTACAAAGGCTCCACAAGTCATCATCTCGTGTCTAGGAAAAGCATC
AGTGCAGCTCTTGAACACAAAGTCAGTGCCCTGCTTACTCCAGCTGAGCAGACAGGCACC
TGGAAACTCAAGACCCAATTTAACAACAATGAATACAGCCAGGACTTGGATGCTTACAAC
ACTAAAGATAAAATTGGCGTGGAGCTTACTGGACGAACTCTGGCTGACCTAACTCTACTA
GACTCCCCAATTAAAGTGCCACTTTTACTCAGTGAGCCCATCAATATCATTGATGCTTTA
GAGATGAGAGATGCCGTTGAGAAGCCCCAAGAATTTACAATTGTTGCTTTTGTAAAGTAT
GATAAAAACCAAGATGTTCACTCCATTAACCTCCCATTTTTTGAGACCTTGCAAGAATAT
TTTGAGAGGAATCGACAAACCATTATAGTTGTAGTGGAAAACGTACAGAGAAACCTGAAG
CACATCAATATTGATCAATTTGTAAGAAAATACAGAGCAGCCCTGGGAAAACTCCCACAG
CAAGCTAATGATTATCTGAATTCATTCAATTGGGAGAGACAAGTTTCACATGCCAAGGAG
AAACTGACTGCTCTCACAAAAAAGTATAGAATTACAGAAAATGATATACAAATTGCATTA
GATGATGCCAAAATCAACTTTAATGAAAAACTATCTCAACTGCAGACATATATGATACAA
TTTGATCAGTATATTAAAGATAGTTATGATTTACATGATTTGAAAATAGCTATTGCTAAT
ATTATTGATGAAATCATTGAAAAATTAAAAAGTCTTGATGAGCACTATCATATCCGTGTA
AATTTAGTAAAAACAATCCATGATCTACATTTGTTTATTGAAAATATTGATTTTAACAAA
AGTGGAAGTAGTACTGCATCCTGGATTCAAAATGTGGATACTAAGTACCAAATCAGAATC
CAGATACAAGAAAAACTGCAGCAGCTTAAGAGACACATACAGAATATAGACATCCAGCAC
CTAGCTGGAAAGTTAAAACAACACATTGAGGCTATTGATGTTAGAGTGCTTTTAGATCAA
TTGGGAACTACAATTTCATTTGAAAGAATAAATGATGTTCTTGAGCATGTCAAACACTTT
GTTATAAATCTTATTGGGGATTTTGAAGTAGCTGAGAAAATCAATGCCTTCAGAGCCAAA
GTCCATGAGTTAATCGAGAGGTATGAAGTAGACCAACAAATCCAGGTTTTAATGGATAAA
TTAGTAGAGTTGACCCACCAATACAAGTTGAAGGAGACTATTCAGAAGCTAAGCAATGTC
CTACAACAAGTTAAGATAAAAGATTACTTTGAGAAATTGGTTGGATTTATTGATGATGCT
GTGAAGAAGCTTAATGAATTATCTTTTAAAACATTCATTGAAGATGTTAACAAATTCCTT
GACATGTTGATAAAGAAATTAAAGTCATTTGATTACCACCAGTTTGTAGATGAAACCAAT
GACAAAATCCGTGAGGTGACTCAGAGACTCAATGGTGAAATTCAGGCTCTGGAACTACCA
CAAAAAGCTGAAGCATTAAAACTGTTTTTAGAGGAAACCAAGGCCACAGTTGCAGTGTAT
CTGGAAAGCCTACAGGACACCAAAATAACCTTAATCATCAATTGGTTACAGGAGGCTTTA
AGTTCAGCATCTTTGGCTCACATGAAGGCCAAATTCCGAGAGACTCTAGAAGATACACGA
GACCGAATGTATCAAATGGACATTCAGCAGGAACTTCAACGATACCTGTCTCTGGTAGGC
CAGGTTTATAGCACACTTGTCACCTACATTTCTGATTGGTGGACTCTTGCTGCTAAGAAC
CTTACTGACTTTGCAGAGCAATATTCTATCCAAGATTGGGCTAAACGTATGAAAGCATTG
GTAGAGCAAGGGTTCACTGTTCCTGAAATCAAGACCATCCTTGGGACCATGCCTGCCTTT
GAAGTCAGTCTTCAGGCTCTTCAGAAAGCTACCTTCCAGACACCTGATTTTATAGTCCCC
CTAACAGATTTGAGGATTCCATCAGTTCAGATAAACTTCAAAGACTTAAAAAATATAAAA
ATCCCATCCAGGTTTTCCACACCAGAATTTACCATCCTTAACACCTTCCACATTCCTTCC
TTTACAATTGACTTTGTCGAAATGAAAGTAAAGATCATCAGAACCATTGACCAGATGCAG
AACAGTGAGCTGCAGTGGCCCGTTCCAGATATATATCTCAGGGATCTGAAGGTGGAGGAC
ATTCCTCTAGCGAGAATCACCCTGCCAGACTTCCGTTTACCAGAAATCGCAATTCCAGAA
TTCATAATCCCAACTCTCAACCTTAATGATTTTCAAGTTCCTGACCTTCACATACCAGAA
TTCCAGCTTCCCCACATCTCACACACAATTGAAGTACCTACTTTTGGCAAGCTATACAGT
ATTCTGAAAATCCAATCTCCTCTTTTCACATTAGATGCAAATGCTGACATAGGGAATGGA
ACCACCTCAGCAAACGAAGCAGGTATCGCAGCTTCCATCACTGCCAAAGGAGAGTCCAAA
TTAGAAGTTCTCAATTTTGATTTTCAAGCAAATGCACAACTCTCAAACCCTAAGATTAAT
CCGCTGGCTCTGAAGGAGTCAGTGAAGTTCTCCAGCAAGTACCTGAGAACGGAGCATGGG
AGTGAAATGCTGTTTTTTGGAAATGCTATTGAGGGAAAATCAAACACAGTGGCAAGTTTA
CACACAGAAAAAAATACACTGGAGCTTAGTAATGGAGTGATTGTCAAGATAAACAATCAG
CTTACCCTGGATAGCAACACTAAATACTTCCACAAATTGAACATCCCCAAACTGGACTTC
TCTAGTCAGGCTGACCTGCGCAACGAGATCAAGACACTGTTGAAAGCTGGCCACATAGCA
TGGACTTCTTCTGGAAAAGGGTCATGGAAATGGGCCTGCCCCAGATTCTCAGATGAGGGA
ACACATGAATCACAAATTAGTTTCACCATAGAAGGACCCCTCACTTCCTTTGGACTGTCC
AATAAGATCAATAGCAAACACCTAAGAGTAAACCAAAACTTGGTTTATGAATCTGGCTCC
CTCAACTTTTCTAAACTTGAAATTCAATCACAAGTCGATTCCCAGCATGTGGGCCACAGT
GTTCTAACTGCTAAAGGCATGGCACTGTTTGGAGAAGGGAAGGCAGAGTTTACTGGGAGG
CATGATGCTCATTTAAATGGAAAGGTTATTGGAACTTTGAAAAATTCTCTTTTCTTTTCA
GCCCAGCCATTTGAGATCACGGCATCCACAAACAATGAAGGGAATTTGAAAGTTCGTTTT
CCATTAAGGTTAACAGGGAAGATAGACTTCCTGAATAACTATGCACTGTTTCTGAGTCCC
AGTGCCCAGCAAGCAAGTTGGCAAGTAAGTGCTAGGTTCAATCAGTATAAGTACAACCAA
AATTTCTCTGCTGGAAACAACGAGAACATTATGGAGGCCCATGTAGGAATAAATGGAGAA
GCAAATCTGGATTTCTTAAACATTCCTTTAACAATTCCTGAAATGCGTCTACCTTACACA
ATAATCACAACTCCTCCACTGAAAGATTTCTCTCTATGGGAAAAAACAGGCTTGAAGGAA
TTCTTGAAAACGACAAAGCAATCATTTGATTTAAGTGTAAAAGCTCAGTATAAGAAAAAC
AAACACAGGCATTCCATCACAAATCCTTTGGCTGTGCTTTGTGAGTTTATCAGTCAGAGC
ATCAAATCCTTTGACAGGCATTTTGAAAAAAACAGAAACAATGCATTAGATTTTGTCACC
AAATCCTATAATGAAACAAAAATTAAGTTTGATAAGTACAAAGCTGAAAAATCTCACGAC
GAGCTCCCCAGGACCTTTCAAATTCCTGGATACACTGTTCCAGTTGTCAATGTTGAAGTG
TCTCCATTCACCATAGAGATGTCGGCATTCGGCTATGTGTTCCCAAAAGCAGTCAGCATG
CCTAGTTTCTCCATCCTAGGTTCTGACGTCCGTGTGCCTTCATACACATTAATCCTGCCA
TCATTAGAGCTGCCAGTCCTTCATGTCCCTAGAAATCTCAAGCTTTCTCTTCCACATTTC
AAGGAATTGTGTACCATAAGCCATATTTTTATTCCTGCCATGGGCAATATTACCTATGAT
TTCTCCTTTAAATCAAGTGTCATCACACTGAATACCAATGCTGAACTTTTTAACCAGTCA
GATATTGTTGCTCATCTCCTTTCTTCATCTTCATCTGTCATTGATGCACTGCAGTACAAA
TTAGAGGGCACCACAAGATTGACAAGAAAAAGGGGATTGAAGTTAGCCACAGCTCTGTCT
CTGAGCAACAAATTTGTGGAGGGTAGTCATAACAGTACTGTGAGCTTAACCACGAAAAAT
ATGGAAGTGTCAGTGGCAAAAACCACAAAAGCCGAAATTCCAATTTTGAGAATGAATTTC
AAGCAAGAACTTAATGGAAATACCAAGTCAAAACCTACTGTCTCTTCCTCCATGGAATTT
AAGTATGATTTCAATTCTTCAATGCTGTACTCTACCGCTAAAGGAGCAGTTGACCACAAG
CTTAGCTTGGAAAGCCTCACCTCTTACTTTTCCATTGAGTCATCTACCAAAGGAGATGTC
AAGGGTTCGGTTCTTTCTCGGGAATATTCAGGAACTATTGCTAGTGAGGCCAACACTTAC
TTGAATTCCAAGAGCACACGGTCTTCAGTGAAGCTGCAGGGCACTTCCAAAATTGATGAT
ATCTGGAACCTTGAAGTAAAAGAAAATTTTGCTGGAGAAGCCACACTCCAACGCATATAT
TCCCTCTGGGAGCACAGTACGAAAAACCACTTACAGCTAGAGGGCCTCTTTTTCACCAAC
GGAGAACATACAAGCAAAGCCACCCTGGAACTCTCTCCATGGCAAATGTCAGCTCTTGTT
CAGGTCCATGCAAGTCAGCCCAGTTCCTTCCATGATTTCCCTGACCTTGGCCAGGAAGTG
GCCCTGAATGCTAACACTAAGAACCAGAAGATCAGATGGAAAAATGAAGTCCGGATTCAT
TCTGGGTCTTTCCAGAGCCAGGTCGAGCTTTCCAATGACCAAGAAAAGGCACACCTTGAC
ATTGCAGGATCCTTAGAAGGACACCTAAGGTTCCTCAAAAATATCATCCTACCAGTCTAT
GACAAGAGCTTATGGGATTTCCTAAAGCTGGATGTAACCACCAGCATTGGTAGGAGACAG
CATCTTCGTGTTTCAACTGCCTTTGTGTACACCAAAAACCCCAATGGCTATTCATTCTCC
ATCCCTGTAAAAGTTTTGGCTGATAAATTCATTACTCCTGGGCTGAAACTAAATGATCTA
AATTCAGTTCTTGTCATGCCTACGTTCCATGTCCCATTTACAGATCTTCAGGTTCCATCG
TGCAAACTTGACTTCAGAGAAATACAAATCTATAAGAAGCTGAGAACTTCATCATTTGCC
CTCAACCTACCAACACTCCCCGAGGTAAAATTCCCTGAAGTTGATGTGTTAACAAAATAT
TCTCAACCAGAAGACTCCTTGATTCCCTTTTTTGAGATAACCGTGCCTGAATCTCAGTTA
ACTGTGTCCCAGTTCACGCTTCCAAAAAGTGTTTCAGATGGCATTGCTGCTTTGGATCTA
AATGCAGTAGCCAACAAGATCGCAGACTTTGAGTTGCCCACCATCATCGTGCCTGAGCAG
ACCATTGAGATTCCCTCCATTAAGTTCTCTGTACCTGCTGGAATTGTCATTCCTTCCTTT
CAAGCACTGACTGCACGCTTTGAGGTAGACTCTCCCGTGTATAATGCCACTTGGAGTGCC
AGTTTGAAAAACAAAGCAGATTATGTTGAAACAGTCCTGGATTCCACATGCAGCTCAACC
GTACAGTTCCTAGAATATGAACTAAATGTTTTGGGAACACACAAAATCGAAGATGGTACG
TTAGCCTCTAAGACTAAAGGAACACTTGCACACCGTGACTTCAGTGCAGAATATGAAGAA
GATGGCAAATTTGAAGGACTTCAGGAATGGGAAGGAAAAGCGCACCTCAATATCAAAAGC
CCAGCGTTCACCGATCTCCATCTGCGCTACCAGAAAGACAAGAAAGGCATCTCCACCTCA
GCAGCCTCCCCAGCCGTAGGCACCGTGGGCATGGATATGGATGAAGATGACGACTTTTCT
AAATGGAACTTCTACTACAGCCCTCAGTCCTCTCCAGATAAAAAACTCACCATATTCAAA
ACTGAGTTGAGGGTCCGGGAATCTGATGAGGAAACTCAGATCAAAGTTAATTGGGAAGAA
GAGGCAGCTTCTGGCTTGCTAACCTCTCTGAAAGACAACGTGCCCAAGGCCACAGGGGTC
CTTTATGATTATGTCAACAAGTACCACTGGGAACACACAGGGCTCACCCTGAGAGAAGTG
TCTTCAAAGCTGAGAAGAAATCTGCAGAACAATGCTGAGTGGGTTTATCAAGGGGCCATT
AGGCAAATTGATGATATCGACGTGAGGTTCCAGAAAGCAGCCAGTGGCACCACTGGGACC
TACCAAGAGTGGAAGGACAAGGCCCAGAATCTGTACCAGGAACTGTTGACTCAGGAAGGC
CAAGCCAGTTTCCAGGGACTCAAGGATAACGTGTTTGATGGCTTGGTACGAGTTACTCAA
AAATTCCATATGAAAGTCAAGCATCTGATTGACTCACTCATTGATTTTCTGAACTTCCCC
AGATTCCAGTTTCCGGGGAAACCTGGGATATACACTAGGGAGGAACTTTGCACTATGTTC
ATAAGGGAGGTAGGGACGGTACTGTCCCAGGTATATTCGAAAGTCCATAATGGTTCAGAA
ATACTGTTTTCCTATTTCCAAGACCTAGTGATTACACTTCCTTTCGAGTTAAGGAAACAT
AAACTAATAGATGTAATCTCGATGTATAGGGAACTGTTGAAAGATTTATCAAAAGAAGCC
CAAGAGGTATTTAAAGCCATTCAGTCTCTCAAGACCACAGAGGTGCTACGTAATCTTCAG
GACCTTTTACAATTCATTTTCCAACTAATAGAAGATAACATTAAACAGCTGAAAGAGATG
AAATTTACTTATCTTATTAATTATATCCAAGATGAGATCAACACAATCTTCAATGATTAT
ATCCCATATGTTTTTAAATTGTTGAAAGAAAACCTATGCCTTAATCTTCATAAGTTCAAT
GAATTTATTCAAAACGAGCTTCAGGAAGCTTCTCAAGAGTTACAGCAGATCCATCAATAC
ATTATGGCCCTTCGTGAAGAATATTTTGATCCAAGTATAGTTGGCTGGACAGTGAAATAT
TATGAACTTGAAGAAAAGATAGTCAGTCTGATCAAGAACCTGTTAGTTGCTCTTAAGGAC
TTCCATTCTGAATATATTGTCAGTGCCTCTAACTTTACTTCCCAACTCTCAAGTCAAGTT
GAGCAATTTCTGCACAGAAATATTCAGGAATATCTTAGCATCCTTACCGATCCAGATGGA
AAAGGGAAAGAGAAGATTGCAGAGCTTTCTGCCACTGCTCAGGAAATAATTAAAAGCCAG
GCCATTGCGACGAAGAAAATAATTTCTGATTACCACCAGCAGTTTAGATATAAACTGCAA
GATTTTTCAGACCAACTCTCTGATTACTATGAAAAATTTATTGCTGAATCCAAAAGATTG
ATTGACCTGTCCATTCAAAACTACCACACATTTCTGATATACATCACGGAGTTACTGAAA
AAGCTGCAATCAACCACAGTCATGAACCCCTACATGAAGCTTGCTCCAGGAGAACTTACT
ATCATCCTCTAA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
X04506

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_6_Locus:
2p24-p23

# Macromolecular_Interacting_Partner_6_SNPs:
rs1367117; rs1801699; rs12713681; rs2163204; rs12713844; rs676210; rs1801703; rs12713675; rs1042034; rs12713843; rs6752026; rs12720854; rs679899; rs12713450; rs12720855; rs533617; rs12714192; rs1801695; rs12714214; rs12713559; rs12720843; rs1801701; rs1801702; rs12691202; rs1042031; rs12713540; rs12720801; rs9282603; rs584542; rs12714097; rs12720848; rs12714225; rs13306187; rs1041968; rs12720852; rs6413458; rs12720847; rs12713558; rs12713554; rs12713600; rs12713457; rs1801700; rs693; rs1799812; rs1041952; rs13306196; rs12720850; rs12713501; rs12720763; rs1800480; rs531819; rs673548; rs10205849; rs2678379; rs520354; rs12720825; rs12713771; rs12720773; rs12720781; rs12714034; rs12713911; rs3749054; rs10208524; rs12720796; rs12720832; rs12720774; rs11676704; rs579826; rs570877; rs3791980; rs12720841; rs6719207; rs661665; rs3791981; rs1800479; rs11901649; rs12720821; rs12720798; rs12714226; rs12713998; rs12714233; rs1800478; rs12720842; rs11126598; rs12720791; rs2854725; rs550619; rs12720770; rs11680233; rs12720771; rs12720813; rs12720833; rs12713799; rs12720797; rs12720812; rs1469513; rs12720844; rs12720828; rs12720795; rs12720803; rs3828293; rs12691188; rs12720851; rs10701091; rs12720783; rs12720794; rs12720808; rs12713908; rs12720826; rs12720768; rs12720782; rs12720800; rs12714221; rs12720814; rs12720762; rs12720849; rs497166; rs12720805; rs11902466; rs12720802; rs12720785; rs12714252; rs12720836; rs12714102; rs12714224; rs12720792; rs9282605; rs12720834; rs12720840; rs12720853; rs12720845; rs12720829; rs12720822; rs12720807; rs12720788; rs12720778; rs12713523; rs12720838; rs12720804; rs12713917; rs12720787; rs12714254; rs12720799; rs12713997; rs12720823; rs12714189; rs12720827; rs12720765; rs12713956; rs12714245; rs6729524; rs10199768; rs12720820; rs12713870; rs597331; rs12720789; rs12714264; rs12720839; rs12720772; rs12720810; rs12720779; rs12720793; rs12713868; rs12720767; rs12720815; rs488329; rs768226; rs12720811; rs12720764; rs12720817; rs12720758; rs12720759; rs9282604; rs12720786; rs12720769; rs12720816; rs13306197; rs768227; rs12714239; rs12720846; rs12720835; rs12714269; rs12713869; rs12720761; rs12714268; rs12714215; rs12713776; rs12720830; rs12720790; rs6727706; rs12714216; rs12720818; rs12720777; rs12714222; rs12714238; rs12713871; rs12720780; rs12714248; rs12714247; rs12720766; rs12720819; rs12720831; rs617314; rs1800481; rs512535; rs934197; rs6547925; rs12713429; rs11883541; rs9282606; rs9282608; rs9282607; rs11687484; rs1041971; rs1042021; rs1042013; rs4362589; rs1801696; rs35708286; rs1800476; rs13306194; rs41288783; rs13306206; rs1042027; rs1126468; rs1801694; rs535237; rs1041960; rs13306191; rs1042025; rs5742904; rs568413; rs13306190; rs1042022; rs13306198; rs1864423; rs13306204; rs1801698; rs1042023; rs1801697; rs1041956; rs1041962; rs13306192; rs13306195; rs1042006; rs13306188; rs13306200; rs1041974; rs13306203; rs13306193; rs2854726; rs10595692; rs34920068; rs552428; rs7589300; rs1054527; rs13306202; rs1367116; rs2000998; rs11440527; rs34519317; rs3762565; rs6413457; rs34607237; rs41291161; rs34102309; rs35442885; rs562956; rs13306205; rs2678378; rs35493179; rs9808029; rs34914206; rs41406449; rs2000997; rs11689972; rs13003321; rs35313978; rs13005150; rs35911751; rs35377456; rs3762564; rs35046475; rs34092033; rs13306201; rs34194949; rs34594011; rs1625714; rs10635819; rs35239349; rs1625764; rs34557689; rs13306199; rs34469176; rs1560357; rs35068532; rs35621726; rs10184191; rs10197075; rs11889738; rs11891086; rs11892073; rs11893021; rs12467932; rs12468735; rs13392272; rs1713222; rs1713223; rs17398765; rs34722314; rs34776010; rs4327259; rs4371387; rs547186; rs585967; rs588245; rs589566; rs6725189; rs6756501; rs7575840; rs952274; rs952275

# Macromolecular_Interacting_Partner_6_General_References:
3763409; 3652907; 3759943; 3464946; 3030729; 3461454; 3513177; 2115173; 3001697; 3860836; 6373369; 2567736; 2883086; 3676265; 3841204; 3621347; 2450346; 3426612; 2445342; 3903660; 2994225; 2932736; 3841481; 3024665; 3659919; 3773997; 3087360; 10679026; 1979313; 2563166; 2216805; 7883971; 8889592; 9259199; 9490296; 12551903

# Macromolecular_Interacting_Partner_6_References:
12960170; 16843720

# Macromolecular_Interacting_Partner_7_ID:
7574

# Macromolecular_Interacting_Partner_7_Name:
Cholecystokinins precursor

# Macromolecular_Interacting_Partner_7_Synonyms:
CCK[Contains: Cholecystokinin 58; CCK58; Cholecystokinin 39; CCK39; Cholecystokinin 33; CCK33; Cholecystokinin 12; CCK12; Cholecystokinin 8; CCK8]

# Macromolecular_Interacting_Partner_7_Gene_Name:
CCK

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Cholecystokinins precursor
MNSGVCLCVLMAVLAAGALTQPVPPADPAGSGLQRAEEAPRRQLRVSQRTDGESRAHLGA
LLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDFGRRSAEEYEYPS

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
115

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
12670

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
9.22

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00918:Gastrin

# Macromolecular_Interacting_Partner_7_Signals:
1-20

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
179996

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
CCKN_HUMAN (P06307)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
CCK

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
CCK

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:1569

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>348 bp
ATGAACAGCGGCGTGTGCCTGTGCGTGCTGATGGCGGTACTGGCGGCTGGCGCCCTGACG
CAGCCGGTGCCTCCCGCAGATCCCGCGGGCTCCGGGCTGCAGCGGGCAGAGGAGGCGCCC
CGTAGGCAGCTGAGGGTATCGCAGAGAACGGATGGCGAGTCCCGAGCGCACCTGGGCGCC
CTGCTGGCAAGATACATCCAGCAGGCCCGGAAAGCTCCTTCTGGACGAATGTCCATCGTT
AAGAACCTGCAGAACCTGGACCCCAGCCACAGGATAAGTGACCGGGACTACATGGGCTGG
ATGGATTTTGGCCGTCGCAGTGCCGAGGAGTATGAGTACCCCTCCTAG

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
L00354

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_7_Locus:
3p22-p21.3

# Macromolecular_Interacting_Partner_7_SNPs:
rs3774395; rs754635; rs747456; rs1799923; rs747455; rs8192473; rs2241996; rs6784327; rs6762874; rs11571844; rs2241997; rs11571876; rs11571846; rs11571843; rs11571847; rs1868522; rs4377469; rs8192472; rs10865918; rs2278794; rs4602358; rs11129949; rs11571857; rs11571855; rs11571851; rs3774396; rs11571864; rs11571866; rs11571863; rs11571875; rs7616571; rs11571867; rs11571871; rs11571856; rs11571849; rs11571853; rs10865917; rs11129948; rs11571877; rs11571888; rs11571878; rs11571842; rs11571884; rs11571887; rs11571882; rs11571880; rs11571841; rs3806691; rs11571838; rs11571879; rs11571848; rs11559016; rs1050815; rs11571845; rs3774394; rs11328368; rs4634088; rs34621311; rs11571859; rs11298401; rs11345711; rs11571873; rs11571862; rs4266164; rs11571865; rs11571852; rs11571860; rs11571858; rs11571872; rs11571869; rs11571854; rs11571874; rs11571861; rs35155419; rs7371919; rs11571870; rs11571868; rs11571881; rs11571886; rs34853186; rs11571839; rs11571840; rs11571883; rs35292864; rs11571885; rs10460960; rs11129946; rs11129947; rs11129950; rs12493571; rs13069836; rs17071699; rs17071704; rs17071771; rs1867020; rs1868520; rs1868521; rs2029127; rs4450782; rs4488805; rs4533619; rs6605331; rs6786615; rs7615049; rs7621531; rs7628785; rs7628795; rs9311317; rs935111; rs935112; rs9682785; rs9757702; rs9813346; rs9835027

# Macromolecular_Interacting_Partner_7_General_References:
3856870; 11076522

# Macromolecular_Interacting_Partner_7_References:
15212143; 16239368

# Macromolecular_Interacting_Partner_8_ID:
7619

# Macromolecular_Interacting_Partner_8_Name:
Platelet glycoprotein 4

# Macromolecular_Interacting_Partner_8_Synonyms:
Platelet glycoprotein IV; GPIV; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; CD36 antigen; PAS IV; PAS-4 protein; Platelet collagen receptor; Fatty acid translocase; FAT; Thrombospondin receptor

# Macromolecular_Interacting_Partner_8_Gene_Name:
CD36

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Platelet glycoprotein 4
MGCDRNCGLIAGAVIGAVLAVFGGILMPVGDLLIQKTIKKQVVLEEGTIAFKNWVKTGTE
VYRQFWIFDVQNPQEVMMNSSNIQVKQRGPYTYRVRFLAKENVTQDAEDNTVSFLQPNGA
IFEPSLSVGTEADNFTVLNLAVAAASHIYQNQFVQMILNSLINKSKSSMFQVRTLRELLW
GYRDPFLSLVPYPVTTTVGLFYPYNNTADGVYKVFNGKDNISKVAIIDTYKGKRNLSYWE
SHCDMINGTDAASFPPFVEKSQVLQFFSSDICRSIYAVFESDVNLKGIPVYRFVLPSKAF
ASPVENPDNYCFCTEKIISKNCTSYGVLDISKCKEGRPVYISLPHFLYASPDVSEPIDGL
NPNEEEHRTYLDIEPITGFTLQFAKRLQVNLLVKPSEKIQVLKNLKRNYIVPILWLNETG
TIGDEKANMFRSQVTGKINLLGLIEMILLSVGVVMFVAFMISYCACRSKTIK

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
472

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
53054

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
8.06

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular process
Process:  cell adhesion
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF01130:CD36

# Macromolecular_Interacting_Partner_8_Signals:
1-23

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
178671

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
CD36_HUMAN (P16671)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
CD36

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
CD36

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:1663

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1419 bp
ATGGGCTGTGACCGGAACTGTGGGCTCATCGCTGGGGCTGTCATTGGTGCTGTCCTGGCT
GTGTTTGGAGGTATTCTAATGCCAGTTGGAGACCTGCTTATCCAGAAGACAATTAAAAAG
CAAGTTGTCCTCGAAGAAGGTACAATTGCTTTTAAAAATTGGGTTAAAACAGGCACAGAA
GTTTACAGACAGTTTTGGATCTTTGATGTGCAAAATCCACAGGAAGTGATGATGAACAGC
AGCAACATTCAAGTTAAGCAAAGAGGTCCTTATACGTACAGAGTTCGTTTTCTAGCCAAG
GAAAATGTAACCCAGGACGCTGAGGACAACACAGTCTCTTTCCTGCAGCCCAATGGTGCC
ATCTTCGAACCTTCACTATCAGTTGGAACAGAGGCTGACAACTTCACAGTTCTCAATCTG
GCTGTGGCAGCTGCATCCCATATCTATCAAAATCAATTTGTTCAAATGATCCTCAATTCA
CTTATTAACAAGTCAAAATCTTCTATGTTCCAAGTCAGAACTTTGAGAGAACTGTTATGG
GGCTATAGGGATCCATTTTTGAGTTTGGTTCCGTACCCTGTTACTACCACAGTTGGTCTG
TTTTATCCTTACAACAATACTGCAGATGGAGTTTATAAAGTTTTCAATGGAAAAGATAAC
ATAAGTAAAGTTGCCATAATCGACACATATAAAGGTAAAAGGAATCTGTCCTATTGGGAA
AGTCACTGCGACATGATTAATGGTACAGATGCAGCCTCATTTCCACCTTTTGTTGAGAAA
AGCCAGGTATTGCAGTTCTTTTCTTCTGATATTTGCAGGTCAATCTATGCTGTATTTGAA
TCCGACGTTAATCTGAAAGGAATCCCTGTGTATAGATTTGTTCTTCCATCCAAGGCCTTT
GCCTCTCCAGTTGAAAACCCAGACAACTATTGTTTCTGCACAGAAAAAATTATCTCAAAA
AATTGTACATCATATGGTGTGCTAGACATCAGCAAATGCAAAGAAGGGAGACCTGTGTAC
ATTTCACTTCCTCATTTTCTGTATGCAAGTCCTGATGTTTCAGAACCTATTGATGGATTA
AACCCAAATGAAGAAGAACATAGGACATACTTGGATATTGAACCTATAACTGGATTCACT
TTACAATTTGCAAAACGGCTGCAGGTCAACCTATTGGTCAAGCCATCAGAAAAAATTCAA
GTATTAAAGAATCTGAAGAGGAACTATATTGTGCCTATTCTTTGGCTTAATGAGACTGGG
ACCATTGGTGATGAGAAGGCAAACATGTTCAGAAGTCAAGTAACTGGAAAAATAAACCTC
CTTGGCCTGATAGAAATGATCTTACTCAGTGTTGGTGTGGTGATGTTTGTTGCTTTTATG
ATTTCATATTGTGCATGCAGATCGAAAACAATAAAATAA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
M24795

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_8_Locus:
7q11.2

# Macromolecular_Interacting_Partner_8_SNPs:
rs3211938; rs1803256; rs5957; rs5956; rs3211907; rs1194181; rs3212161; rs1949818; rs7755; rs1722505; rs1761661; rs1464792; rs1194179; rs1413661; rs1194178; rs2691199; rs3212160; rs6973242; rs2151916; rs3211958; rs1537593; rs1537477; rs1722506; rs3211959; rs1761665; rs6968407; rs1205467; rs12532196; rs3212162; rs1049654; rs6960369; rs3212164; rs1761667; rs1194180; rs4545029; rs1761663; rs3212163; rs1722507; rs10268404; rs4728183; rs11971740; rs6972923; rs1722502; rs10268417; rs9918586; rs12531218; rs10268765; rs10499858; rs3212018; rs1537591; rs10499859; rs10215288; rs3211956; rs1880410; rs12534733; rs12536106; rs1360741; rs17263407; rs1572230; rs12531609; rs1984112; rs10268662; rs3212159; rs1334513; rs1527479; rs10216184; rs2691200; rs17154155; rs12533372; rs1194177; rs13236689; rs4410854; rs10238304; rs4731642; rs2366855; rs1413657; rs1334511; rs3044712; rs10267891; rs1534314; rs12540395; rs11574729; rs11983805; rs9784998; rs1761664; rs10429164; rs1334516; rs3211805; rs4731643; rs10225432; rs6961024; rs1334512; rs13228738; rs12706912; rs11972894; rs10499860; rs13225492; rs1413656; rs1722509; rs12234728; rs13438282; rs11971793; rs1953298; rs10480808; rs6969989; rs12540402; rs11770907; rs1722504; rs7812074; rs8956; rs12706918; rs2781844; rs17154170; rs17154181; rs12667404; rs11770358; rs1722503; rs1413659; rs10265780; rs10265215; rs1761662; rs3211960; rs4728191; rs11771152; rs10247260; rs13222488; rs9641866; rs11574728; rs12532729; rs1953299; rs4731646; rs17154186; rs3211849; rs3211928; rs3211931; rs3211821; rs3173804; rs3211822; rs997906; rs3211920; rs3211944; rs1924; rs3211867; rs3211834; rs3211940; rs3173799; rs3211886; rs3211883; rs3211909; rs1358337; rs3211845; rs3211816; rs3212165; rs3211885; rs3211820; rs3211828; rs3211942; rs3211839; rs3173798; rs3211827; rs1054516; rs3211851; rs3211887; rs3807075; rs1880955; rs6953487; rs11574716; rs10499861; rs3211954; rs3211850; rs3211908; rs1527483; rs3211869; rs3807076; rs3211846; rs3807090; rs3211911; rs3211842; rs7810964; rs3211905; rs3211864; rs3173802; rs3211838; rs3211932; rs3807073; rs3173805; rs3211830; rs3807077; rs3211913; rs1405747; rs3211844; rs3211817; rs3817556; rs3211917; rs3211831; rs3211810; rs3211881; rs3173800; rs3211818; rs3211812; rs3211843; rs3211912; rs3211868; rs3800553; rs3211916; rs10499862; rs3211949; rs3211915; rs3211825; rs3211904; rs17154239; rs3173803; rs3212001; rs3211895; rs3211863; rs17154233; rs9282633; rs3212004; rs17154209; rs3211999; rs3211813; rs3211910; rs3211947; rs3211866; rs1880956; rs3211819; rs3211874; rs3211933; rs17154258; rs3211870; rs3211903; rs3211854; rs3211858; rs3211896; rs3211897; rs3211852; rs3212012; rs3212008; rs9282636; rs3212005; rs3212170; rs3211952; rs11574715; rs3211919; rs3211890; rs3212011; rs3211925; rs3211848; rs3211945; rs3211872; rs3211809; rs9282634; rs17154246; rs3173801; rs3211902; rs3211841; rs3211891; rs3211808; rs3211873; rs4986864; rs3211857; rs3211824; rs17154232; rs3211815; rs3211876; rs3211884; rs3211811; rs1527484; rs17154225; rs3211929; rs3211914; rs9282635; rs3212003; rs4986863; rs3211878; rs3211856; rs3211865; rs3211918; rs3211946; rs1054517; rs9282637; rs3211892; rs1527463; rs3211899; rs3211935; rs3211926; rs3211939; rs3211906; rs3211888; rs3211823; rs3211859; rs3211889; rs3211927; rs3211879; rs3212009; rs3211875; rs3212000; rs17154213; rs3211880; rs3211826; rs3211814; rs3211934; rs17265158; rs3211871; rs3211930; rs3823475; rs3211806; rs3211941; rs3211855; rs1133344; rs11574709; rs3211923; rs3211882; rs3211836; rs3212013; rs1194182; rs1049673; rs13246513; rs17154137; rs17154133; rs35398731; rs2272350; rs4645507; rs35793888; rs3211861; rs13306227; rs35776095; rs41478146; rs1130696; rs3211901; rs3211893; rs12055955; rs34129321; rs33926837; rs3044666; rs10428893; rs11450631; rs34416933; rs1969494; rs12530754; rs11301209; rs35342482; rs28645928; rs34620540; rs11402083; rs35216295; rs41272369; rs13306226; rs5885184; rs7782100; rs35880722; rs35726535; rs10252678; rs35503056; rs1537592; rs36088538; rs11321468; rs1722501; rs35179913; rs9918530; rs34516458; rs12530623; rs1722508; rs13310587; rs13311181; rs34388229; rs5885188; rs1722510; rs35775198; rs34462103; rs34229217; rs13311175; rs10633454; rs6150187; rs7784648; rs10235039; rs35355478; rs36122853; rs1953300; rs35176633; rs35638681; rs4626520; rs1334517; rs3040906; rs13311184; rs11489664; rs13312376; rs13310579; rs17154147; rs3044686; rs3211957; rs34638645; rs7811490; rs34555144; rs13311245; rs13306228; rs34217287; rs5885187; rs34710564; rs34345674; rs34761395; rs34829889; rs34745595; rs2691198; rs4316098; rs36055469; rs35289985; rs34028827; rs11294590; rs7808408; rs35802187; rs34781678; rs36013152; rs1722511; rs34801616; rs7778263; rs34506573; rs35574453; rs5885186; rs33940674; rs34493313; rs10643354; rs35574179; rs12706916; rs13244883; rs1413660; rs35468175; rs1334514; rs2366856; rs28694631; rs5885185; rs13312487; rs13233631; rs10228291; rs34289333; rs13244869; rs1334515; rs11318589; rs35634523; rs10265457; rs41272372; rs3044710; rs3211924; rs4986862; rs1133345; rs11574718; rs28428736; rs3212017; rs11437085; rs35439945; rs11574721; rs3211953; rs3847100; rs3212014; rs3212007; rs3736592; rs28441220; rs34304108; rs3211829; rs28462358; rs3212002; rs11464530; rs3212166; rs35268194; rs7457162; rs3212169; rs10249908; rs35368854; rs3211900; rs3212015; rs3211833; rs35200450; rs11450578; rs41281225; rs41364549; rs1054518; rs34461332; rs3211951; rs3211853; rs11574711; rs10263695; rs3212006; rs3212168; rs3915268; rs3211936; rs10263961; rs10669209; rs3211840; rs3211937; rs13221438; rs3211922; rs3211835; rs10270675; rs3807074; rs3211921; rs28659874; rs3807085; rs3211837; rs3832458; rs11574703; rs41274179; rs10249784; rs3044693; rs3211950; rs5885189; rs3211847; rs34141101; rs10718681; rs3211898; rs34761121; rs34614420; rs35463927; rs10536999; rs2065667; rs34744646; rs2065666; rs35106817; rs3211862; rs10245610; rs10262906; rs10263763; rs10499856; rs10499857; rs11771839; rs11772036; rs12666644; rs12706949; rs13223096; rs13226840; rs13230419; rs1334518; rs1524596; rs1524597; rs17154125; rs17154304; rs17154309; rs17154312; rs17154316; rs17154320; rs1722516; rs17266080; rs3807072; rs5012406; rs7789369; rs7807607; rs819435; rs819436; rs819437; rs819439

# Macromolecular_Interacting_Partner_8_General_References:
2473841; 7693552; 7505064; 7518447; 2468669; 11668637; 7503937; 8798390; 7533783; 10391209; 10890433; 11950861; 12506336

# Macromolecular_Interacting_Partner_8_References:
15161924

# Macromolecular_Interacting_Partner_9_ID:
7632

# Macromolecular_Interacting_Partner_9_Name:
Neurotrophin-3 precursor

# Macromolecular_Interacting_Partner_9_Synonyms:
NT-3; Neurotrophic factor; HDNF; Nerve growth factor 2; NGF-2

# Macromolecular_Interacting_Partner_9_Gene_Name:
NTF3

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Neurotrophin3 precursor
MSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQ
STLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRYNSPRVLLSDSTPLEPPPLYLM
EDYVGSPVVANRTSRRKRYAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIK
TGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWI
RIDTSCVCALSRKIGRT

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
257

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
29355

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
9.80

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Seems to promotes the survival of visceral and proprioceptive sensory neurons

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00243:NGF

# Macromolecular_Interacting_Partner_9_Signals:
1-16

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
287795

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
NT3_HUMAN (P20783)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
NTF3

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
NTF3

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:8023

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>774 bp
ATGTCCATCTTGTTTTATGTGATATTTCTCGCTTATCTCCGTGGCATCCAAGGTAACAAC
ATGGATCAAAGGAGTTTGCCAGAAGACTCGCTCAATTCCCTCATTATTAAGCTGATCCAG
GCAGATATTTTGAAAAACAAGCTCTCCAAGCAGATGGTGGACGTTAAGGAAAATTACCAG
AGCACCCTGCCCAAAGCTGAGGCTCCCCGAGAGCCGGAGCGGGGAGGGCCCGCCAAGTCA
GCATTCCAGCCAGTGATTGCAATGGACACCGAACTGCTGCGACAACAGAGACGCTACAAC
TCACCGCGGGTCCTGCTGAGCGACAGCACCCCCTTGGAGCCCCCGCCCTTGTATCTCATG
GAGGATTACGTGGGCAGCCCCGTGGTGGCGAACAGAACATCACGGCGGAAACGGTACGCG
GAGCATAAGAGTCACCGAGGGGAGTACTCGGTATGTGACAGTGAGAGTCTGTGGGTGACC
GACAAGTCATCGGCCATCGACATTCGGGGACACCAGGTCACGGTGCTGGGGGAGATCAAA
ACGGGCAACTCTCCCGTCAAACAATATTTTTATGAAACGCGATGTAAGGAAGCCAGGCCG
GTCAAAAACGGTTGCAGGGGTATTGATGATAAACACTGGAACTCTCAGTGCAAAACATCC
CAAACCTACGTCCGAGCACTGACTTCAGAGAACAATAAACTCGTGGGCTGGCGGTGGATA
CGGATAGACACGTCCTGTGTGTGTGCCTTGTCGAGAAAAATCGGAAGAACATGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
X53655

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_9_Locus:
12p13

# Macromolecular_Interacting_Partner_9_SNPs:
rs1805149; rs6332; rs10849277; rs11063713; rs1805150; rs35988749; rs6489629; rs6489630; rs12424349; rs11063714; rs34320858; rs10161033; rs10744685; rs10774334; rs10849276; rs10849278; rs10849279; rs11063707; rs11063708; rs11063709; rs11063711; rs11063712; rs11063715; rs11063717; rs11063718; rs11612899; rs11614714; rs12303980; rs12306918; rs12313405; rs12315115; rs12424162; rs34581657; rs35691544; rs3890792; rs3924027; rs3935822; rs4073543; rs4074967; rs4075788; rs4075789; rs4077470; rs4077471; rs4930767; rs4930817; rs4930818; rs4930820; rs6489628; rs7300425; rs7301972; rs7304577; rs7484401; rs7484632; rs7484874; rs7484877; rs7485102; rs7488316; rs7956189; rs7965477; rs7971446; rs7974899

# Macromolecular_Interacting_Partner_9_General_References:
2344409; 2236018; 2365067; 1889806; 2025430; 7703225; 7733919; 8925252

# Macromolecular_Interacting_Partner_9_References:
12445905; 14519521; 15573408

# Macromolecular_Interacting_Partner_10_ID:
6942

# Macromolecular_Interacting_Partner_10_Name:
Microsomal triglyceride transfer protein large subunit precursor

# Macromolecular_Interacting_Partner_10_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_10_Gene_Name:
MTTP

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Microsomal triglyceride transfer protein large subunit precursor
MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRIS
SNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQ
RPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQA
HQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGL
NFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKG
CPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLV
DAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIG
SSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNA
LLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVR
TAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEM
VAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLH
GSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSA
SGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKN
RVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQF
EKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
894

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
99352

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
8.62

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  transporter activity
Function:  lipid transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  lipid transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF01347:Vitellogenin_N

# Macromolecular_Interacting_Partner_10_Signals:
1-18

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
414669

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
MTP_HUMAN (P55157)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
MTTP

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
MTTP

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:7467

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Endoplasmic reticulum

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>2685 bp
ATGATTCTTCTTGCTGTGCTTTTTCTCTGCTTCATTTCCTCATATTCAGCTTCTGTTAAA
GGTCACACAACTGGTCTCTCATTAAATAATGACCGGCTGTACAAGCTCACGTACTCCACT
GAAGTTCTTCTTGATCGGGGCAAAGGAAAACTGCAAGACAGCGTGGGCTACCGCATTTCC
TCCAACGTGGATGTGGCCTTACTATGGAGGAATCCTGATGGTGATGATGACCAGTTGATC
CAAATAACGATGAAGGATGTAAATGTTGAAAATGTGAATCAGCAGAGAGGAGAGAAGAGC
ATCTTCAAAGGAAAAAGCCCATCTAAAATAATGGGAAAGGAAAACTTGGAAGCTCTGCAA
AGACCTACGCTCCTTCATCTAATCCATGGAAAGGTCAAAGAGTTCTACTCATATCAAAAT
GAGGCAGTGGCCATAGAAAATATCAAGAGAGGTCTGGCTAGCCTATTTCAGACACAGTTA
AGCTCTGGAACCACCAATGAGGTAGATATCTCTGGAAATTGTAAAGTGACCTACCAGGCT
CATCAAGACAAAGTGATCAAAATTAAGGCCTTGGATTCATGCAAAATAGCGAGGTCTGGA
TTTACGACCCCAAATCAGGTCTTGGGTGTCAGTTCAAAAGCTACATCTGTCACCACCTAT
AAGATAGAAGACAGCTTTGTTATAGCTGTGCTTGCTGAAGAAACACACAATTTTGGACTG
AATTTCCTACAAACCATTAAGGGGAAAATAGTATCGAAGCAGAAATTAGAGCTGAAGACA
ACCGAAGCAGGCCCAAGATTGATGTCTGGAAAGCAGGCTGCAGCCATAATCAAAGCAGTT
GATTCAAAGTACACGGCCATTCCCATTGTGGGGCAGGTCTTCCAGAGCCACTGTAAAGGA
TGTCCTTCTCTCTCGGAGCTCTGGCGGTCCACCAGGAAATACCTGCAGCCTGACAACCTT
TCCAAGGCTGAGGCTGTCAGAAACTTCCTGGCCTTCATTCAGCACCTCAGGACTGCGAAG
AAAGAAGAGATCCTTCAAATACTAAAGATGGAAAATAAGGAAGTATTACCTCAGCTGGTG
GATGCTGTCACCTCTGCTCAGACCTCAGACTCATTAGAAGCCATTTTGGACTTTTTGGAT
TTCAAAAGTGACAGCAGCATTATCCTCCAGGAGAGGTTTCTCTATGCCTGTGGATTTGCT
TCTCATCCCAATGAAGAACTCCTGAGAGCCCTCATTAGTAAGTTCAAAGGTTCTATTGGT
AGCAGTGACATCAGAGAAACTGTTATGATCATCACTGGGACACTTGTCAGAAAGTTGTGT
CAGAATGAAGGCTGCAAACTCAAAGCAGTAGTGGAAGCTAAGAAGTTAATCCTGGGAGGA
CTTGAAAAAGCAGAGAAAAAAGAGGACACCAGGATGTATCTGCTGGCTTTGAAGAATGCC
CTGCTTCCAGAAGGCATCCCAAGTCTTCTGAAGTATGCAGAAGCAGGAGAAGGGCCCATC
AGCCACCTGGCTACCACTGCTCTCCAGAGATATGATCTCCCTTTCATAACTGATGAGGTG
AAGAAGACCTTAAACAGAATATACCACCAAAACCGTAAAGTTCATGAAAAGACTGTGCGC
ACTGCTGCAGCTGCTATCATTTTAAATAACAATCCATCCTACATGGACGTCAAGAACATC
CTGCTGTCTATTGGGGAGCTTCCCCAAGAAATGAATAAATACATGCTCGCCATTGTTCAA
GACATCCTACGTTTTGAAATGCCTGCAAGCAAAATTGTCCGTCGAGTTCTGAAGGAAATG
GTCGCTCACAATTATGACCGTTTCTCCAGGAGTGGATCTTCTTCTGCCTACACTGGCTAC
ATAGAACGTAGTCCCCGTTCGGCATCTACTTACAGCCTAGACATTCTCTACTCGGGTTCT
GGCATTCTAAGGAGAAGTAACCTGAACATCTTTCAGTACATTGGGAAGGCTGGTCTTCAC
GGTAGCCAGGTGGTTATTGAAGCCCAAGGACTGGAAGCCTTAATCGCAGCCACCCCTGAC
GAGGGGGAGGAGAACCTTGACTCCTATGCTGGTATGTCAGCCATCCTCTTTGATGTTCAG
CTCAGACCTGTCACCTTTTTCAACGGATACAGTGATTTGATGTCCAAAATGCTGTCAGCA
TCTGGCGACCCTATCAGTGTGGTGAAAGGACTTATTCTGCTAATAGATCATTCTCAGGAA
CTTCAGTTACAATCTGGACTAAAAGCCAATATAGAGGTCCAGGGTGGTCTAGCTATTGAT
ATTTCAGGTGCAATGGAGTTTAGCTTGTGGTATCGTGAGTCTAAAACCCGAGTGAAAAAT
AGGGTGACTGTGGTAATAACCACTGACATCACAGTGGACTCCTCTTTTGTGAAAGCTGGC
CTGGAAACCAGTACAGAAACAGAAGCAGGCTTGGAGTTTATCTCCACAGTGCAGTTTTCT
CAGTACCCATTCTTAGTTTGCATGCAGATGGACAAGGATGAAGCTCCATTCAGGCAATTT
GAGAAAAAGTACGAAAGGCTGTCCACAGGCAGAGGTTATGTCTCTCAGAAAAGAAAAGAA
AGCGTATTAGCAGGATGTGAATTCCCGCTCCATCAAGAGAACTCAGAGATGTGCAAAGTG
GTGTTTGCCCCTCAGCCGGATAGTACTTCCAGCGGATGGTTTTGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
X75500

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_10_Locus:
4q24

# Macromolecular_Interacting_Partner_10_SNPs:
rs2306985; rs3816873; rs3792683; rs2306986; rs17029215; rs17599091; rs991811; rs982424; rs17029213; rs17533489; rs7667001; rs7672497; rs6832119; rs745075; rs2298747; rs1057613; rs881981; rs745074; rs881980; rs7693203; rs6532823; rs1491247; rs7661964; rs2306984; rs11937107; rs7698617; rs2035815; rs17029173; rs6841211; rs17029163; rs1491244; rs3828542; rs2255119; rs7698798; rs2903202; rs13105033; rs4699756; rs3805335; rs17533020; rs1491238; rs956201; rs4699755; rs3792681; rs6815416; rs17029189; rs1057615; rs10516445; rs3805336; rs1491237; rs2035814; rs17029211; rs11734413; rs17598940; rs13139650; rs3805337; rs7673840; rs11727265; rs17533517; rs7672098; rs17598226; rs12152646; rs17532992; rs951941; rs17029177; rs34678000; rs13306568; rs3828543; rs2718684; rs17532601; rs2220636; rs11930665; rs5011596; rs13306571; rs4552468; rs2035816; rs1826274; rs2130907; rs956200; rs991812; rs17029165; rs7668586; rs12509976; rs12648918; rs7698822; rs7674195; rs2718677; rs1032355; rs7698448; rs11937273; rs7699525; rs1352777; rs7694204; rs7698411; rs11947616; rs6532821; rs1800591; rs1061271; rs3811800; rs1800803; rs7688278; rs6832927; rs1800804; rs10011440; rs41275711; rs1064901; rs10568763; rs41275707; rs5860582; rs11376480; rs7693976; rs35391686; rs3974790; rs34040809; rs34529437; rs28368786; rs28758750; rs33999929; rs13145096; rs36137045; rs35410186; rs34092272; rs5860583; rs6532822; rs7654460; rs41275717; rs11461458; rs34883891; rs10716076; rs7698547; rs34039502; rs5011595; rs35170496; rs2130906; rs5860584; rs34811849; rs36101674; rs1826273; rs34735377; rs2035813; rs34756677; rs1491246; rs34617286; rs1057614; rs41275709; rs11311776; rs34100267; rs5860587; rs34414077; rs10598154; rs34633694; rs36086882; rs5860585; rs2851225; rs10598156; rs13136165; rs11338789; rs4311319; rs35586439; rs34734558; rs41275713; rs34246356; rs28704064; rs41275721; rs28653005; rs34325929; rs35824615; rs33924572; rs28666735; rs35438117; rs10598153; rs6837699; rs2851224; rs9993533; rs5011593; rs1491239; rs28435607; rs2718678; rs11311775; rs28595160; rs3833621; rs12650733; rs28440180; rs5860586; rs35043772; rs2637768; rs10605949; rs10598155; rs35363569; rs28647519; rs13306570; rs34407563; rs41275719; rs11947558; rs34414638; rs41275715; rs28379462; rs34518814; rs11463615; rs34244951; rs1826272; rs13306573; rs902661; rs34513206; rs1388296; rs12643429; rs34350284; rs4699757; rs13135675; rs35779395; rs34628778; rs34724998; rs11311777; rs34322916; rs10598152; rs10598157; rs13147975; rs28376611; rs28583976; rs36051062; rs35614260; rs36037484; rs34393574; rs13141915; rs35647800; rs5011594; rs28672700; rs7698409; rs34777713; rs5860588; rs35107102; rs1491245; rs13126189; rs10516446; rs10516447; rs10516448; rs10516449; rs11097669; rs11724527; rs11933250; rs11933337; rs11933520; rs11933937; rs11934921; rs11943031; rs11946658; rs12639747; rs12647527; rs13123964; rs13131135; rs13142452; rs1503777; rs1503778; rs17029142; rs17600332; rs2172138; rs35402611; rs4699758; rs6839296; rs6842339; rs6844547; rs7659550; rs7665414; rs7678142; rs7687762; rs9307240; rs958868

# Macromolecular_Interacting_Partner_10_General_References:
8111381; 8361539; 7545943; 7664034; 8533758; 8939939; 10679949; 10946006; 11792722

# Macromolecular_Interacting_Partner_10_References:
12775725; 15723548

# Macromolecular_Interacting_Partner_11_ID:
7694

# Macromolecular_Interacting_Partner_11_Name:
Peroxisome proliferator-activated receptor alpha

# Macromolecular_Interacting_Partner_11_Synonyms:
PPAR-alpha

# Macromolecular_Interacting_Partner_11_Gene_Name:
PPARA

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Peroxisome proliferatoractivated receptor alpha
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
468

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
52226

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
6.20

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  steroid hormone receptor activity
Function:  transcription factor activity
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_11_General_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Specific_Function:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_11_Signals:
None

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
307341

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
PPARA_HUMAN (Q07869)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
PPARA

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
PPARA

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:9232

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>1407 bp
ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAG
AGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGGAAACATCCAAGAGATTTCGCAATCC
ATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT
CCTGGCTCAGATGGCTCGGTCATCACGGACACGCTTTCACCAGCTTCGAGCCCCTCCTCG
GTGACTTATCCTGTGGTCCCCGGCAGCGTGGACGAGTCTCCCAGTGGAGCATTGAACATC
GAATGTAGAATCTGCGGGGACAAGGCCTCAGGCTATCATTACGGAGTCCACGCGTGTGAA
GGCTGCAAGGGCTTCTTTCGGCGAACGATTCGACTCAAGCTGGTGTATGACAAGTGCGAC
CGCAGCTGCAAGATCCAGAAAAAGAACAGAAACAAATGCCAGTATTGTCGATTTCACAAG
TGCCTTTCTGTCGGGATGTCACACAACGCGATTCGTTTTGGACGAATGCCAAGATCTGAG
AAAGCAAAACTGAAAGCAGAAATTCTTACCTGTGAACATGACATAGAAGATTCTGAAACT
GCAGATCTCAAATCTCTGGCCAAGAGAATCTACGAGGCCTACTTGAAGAACTTCAACATG
AACAAGGTCAAAGCCCGGGTCATCCTCTCAGGAAAGGCCAGTAACAATCCACCTTTTGTC
ATACATGATATGGAGACACTGTGTATGGCTGAGAAGACGCTGGTGGCCAAGCTGGTGGCC
AATGGCATCCAGAACAAGGAGGTGGAGGTCCGCATCTTTCACTGCTGCCAGTGCACGTCA
GTGGAGACCGTCACGGAGCTCACGGAATTCGCCAAGGCCATCCCAGCGTTCGCAAACTTG
GACCTGAACGATCAAGTGACATTGCTAAAATACGGAGTTTATGAGGCCATATTCGCCATG
CTGTCTTCTGTGATGAACAAAGACGGGATGCTGGTAGCGTATGGAAATGGGTTTATAACT
CGTGAATTCCTAAAAAGCCTAAGGAAACCGTTCTGTGATATCATGGAACCCAAGTTTGAT
TTTGCCATGAAGTTCAATGCACTGGAACTGGATGACAGTGATATCTCCCTTTTTGTGGCT
GCTATCATTTGCTGTGGAGATCGTCCTGGCCTTCTAAACGTAGGACACATTGAAAAAATG
CAGGAGGGTATTGTACATGTGCTCAGACTCCACCTGCAGAGCAACCACCCGGACGATATC
TTTCTCTTCCCAAAACTTCTTCAAAAAATGGCAGACCTCCGGCAGCTGGTGACGGAGCAT
GCGCAGCTGGTGCAGATCATCAAGAAGACGGAGTCGGATGCTGCGCTGCACCCGCTACTG
CAGGAGATCTACAGGGACATGTACTGA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
L02932

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_11_Locus:
22q12-q13.1|22q13.31

# Macromolecular_Interacting_Partner_11_SNPs:
rs1800206; rs1800234; rs1800204; rs1800235; rs4253773; rs135547; rs129600; rs4253681; rs4253652; rs135552; rs135539; rs135542; rs4253655; rs12330015; rs9627046; rs135538; rs4253663; rs7364220; rs4253620; rs4253698; rs4253781; rs9626729; rs4253758; rs4253699; rs4253630; rs4253682; rs4253703; rs1555208; rs4253701; rs4253622; rs4253704; rs135549; rs4253665; rs4253686; rs4253792; rs6008259; rs4253702; rs4253669; rs135550; rs135543; rs4253621; rs4253788; rs4253678; rs4253695; rs4253791; rs5769177; rs4253674; rs4253671; rs4253641; rs4253624; rs5766696; rs4253639; rs4253618; rs7286168; rs4253786; rs4253784; rs4253651; rs4253757; rs4253800; rs8138102; rs4253635; rs4253670; rs4253789; rs11704856; rs4253660; rs4253645; rs9626736; rs4253797; rs135540; rs4253638; rs4253694; rs8135690; rs4253633; rs4253627; rs4253642; rs4253696; rs4253656; rs4253706; rs4253659; rs4253672; rs4253691; rs4253667; rs9306498; rs5766698; rs4253688; rs4253623; rs4253634; rs4253801; rs1055659; rs135548; rs4253687; rs4253707; rs4253646; rs6008970; rs4253664; rs4253643; rs4253700; rs4253668; rs135555; rs4253685; rs4253640; rs6008976; rs7287085; rs4253705; rs3892755; rs4253661; rs4253626; rs4253637; rs4253658; rs4253629; rs4253782; rs4253647; rs7289836; rs4253679; rs135551; rs4253793; rs4253617; rs4253692; rs4253631; rs4253644; rs4253625; rs9306499; rs4253790; rs4253787; rs4253683; rs4253619; rs4253662; rs4253657; rs5769178; rs4253756; rs4253684; rs4253636; rs135554; rs4253785; rs4253628; rs9626737; rs4253780; rs4253654; rs4253677; rs761543; rs4253783; rs4253648; rs11704979; rs4253680; rs4253616; rs9626814; rs4253653; rs4253693; rs4253673; rs4253632; rs4253650; rs4253689; rs11913649; rs4253666; rs4823902; rs11704508; rs5769243; rs10427717; rs8135547; rs9680739; rs8139731; rs17661656; rs3747246; rs41367645; rs17661718; rs9306500; rs5766804; rs135553; rs41388244; rs9615264; rs16994933; rs41427746; rs16994915; rs6007981; rs17241878; rs10154348; rs12162684; rs11705154; rs11703495; rs135541; rs12160659; rs7287027; rs4823586; rs6009111; rs41378347; rs12169296; rs135545; rs1134224; rs10775794; rs11703746; rs135536; rs9680676; rs12169290; rs9627268; rs5769366; rs17241885; rs7288994; rs9627100; rs7289495; rs1055657; rs6009081; rs135546; rs1800246; rs5767743; rs4253762; rs4253778; rs4253690; rs4823613; rs4253769; rs4253751; rs6008197; rs6519979; rs4253761; rs4253747; rs4253730; rs4253775; rs4253713; rs4253719; rs4253750; rs4253764; rs4253765; rs4253776; rs4253729; rs4253709; rs4253712; rs4253760; rs4253728; rs11090819; rs4253737; rs4253770; rs4253777; rs2336904; rs4253711; rs4253754; rs4253798; rs4253748; rs4253727; rs4253723; rs4253710; rs4253714; rs6008160; rs4253708; rs4253718; rs4253774; rs4253722; rs4253767; rs4253732; rs5766741; rs4253726; rs4253799; rs5767700; rs7364297; rs4253736; rs4253794; rs4253752; rs4253731; rs4253766; rs4253721; rs4253717; rs4253742; rs4253744; rs4253697; rs4253771; rs4253746; rs4253725; rs4253739; rs4253720; rs4253738; rs4253755; rs1800245; rs4253795; rs4253716; rs4253735; rs4253734; rs5766743; rs4253779; rs4253741; rs4253753; rs6007662; rs4253768; rs4253743; rs4253745; rs4253772; rs4253763; rs4253724; rs4253759; rs4253733; rs4253715; rs8139794; rs4253740; rs4253749; rs8139663; rs41397552; rs11090791; rs11702902; rs11090817; rs6008123; rs7291727; rs5769175; rs5767636; rs9615238; rs5767560; rs5766734; rs6008126; rs5767633; rs11090818; rs8140236; rs12170204; rs9626730; rs11705483; rs11913971; rs7292459; rs5767634; rs4823477; rs6413511; rs1800243; rs1800242; rs9615759; rs1042311; rs5767686; rs1800236; rs12167302; rs9615163; rs41418950; rs34666721; rs5769287; rs35328780; rs7292112; rs11383159; rs7364140; rs5769365; rs34148860; rs5845740; rs35404482; rs35249750; rs41403648; rs35988564; rs6009112; rs5845739; rs36096470; rs41532849; rs881740; rs9615524; rs7286871; rs12484245; rs13053358; rs11538240; rs35966870; rs34896841; rs35838035; rs10643430; rs13053293; rs5767779; rs12171095; rs41479847; rs28772875; rs6009058; rs4592961; rs9627007; rs34109484; rs12159525; rs12170381; rs5845741; rs135544; rs41406451; rs35398060; rs28369325; rs5769129; rs12160049; rs34857047; rs12159225; rs6008042; rs7364165; rs10561065; rs7289761; rs5769184; rs9626764; rs12159821; rs5766682; rs41362646; rs41465647; rs3840962; rs5769088; rs41371446; rs2238833; rs4823487; rs9626756; rs7290774; rs41368348; rs5769276; rs34001104; rs35552991; rs28716636; rs13055301; rs5767424; rs12167354; rs1055658; rs41477146; rs5769364; rs36096495; rs5769356; rs35281820; rs35038216; rs41371949; rs5769142; rs11703765; rs35808855; rs6009014; rs41489145; rs9626751; rs135537; rs41355347; rs34437230; rs9615534; rs6007965; rs12159097; rs9615784; rs11344804; rs5769219; rs9615523; rs16994976; rs9626716; rs28895660; rs41329344; rs35345592; rs41489148; rs1800244; rs13054427; rs11912612; rs11703766; rs36124248; rs12166902; rs6008974; rs13055320; rs5769112; rs41332048; rs12169623; rs5769206; rs36074474; rs35436527; rs13056945; rs8139926; rs9627217; rs6008089; rs10570542; rs34977841; rs11325484; rs35637220; rs9615694; rs17847852; rs4365564; rs5767667; rs8135879; rs12166737; rs5767617; rs5766714; rs9626745; rs2336905; rs6008193; rs9615695; rs7290878; rs1973929; rs28875881; rs41526048; rs35528985; rs12168403; rs34108706; rs34716781; rs9626811; rs41461946; rs12168939; rs6008129; rs34902389; rs12166868; rs10563623; rs10427969; rs8141725; rs4365565; rs5767650; rs34142992; rs9627047; rs7290473; rs5767708; rs6008149; rs34052175; rs11703314; rs6008161; rs10593071; rs35418581; rs11445888; rs35658961; rs34873839; rs10658167; rs41497148; rs35027666; rs6008116; rs34774436; rs11270575; rs34036883; rs35700219; rs6008093; rs6007639; rs13057868; rs28669215; rs11332243; rs41343752; rs28508200; rs2283673; rs5767618; rs28786744; rs10591809; rs12170430; rs12168830; rs12167549; rs34858419; rs13058348; rs8141442; rs6008191; rs6008096; rs5767763; rs35145000; rs28584795; rs6007673; rs7286742; rs12168937; rs28828403; rs35615646; rs34406573; rs13058552; rs6008130; rs12166556; rs13056831; rs9626742; rs34363509; rs9615487; rs5767320; rs34775146; rs9626709; rs12157295; rs10154668; rs1053332; rs11705226; rs12106599; rs12159251; rs135556; rs135557; rs135559; rs135560; rs135561; rs135562; rs14842; rs14843; rs16995065; rs16995067; rs16995069; rs5767842; rs6008923; rs717926; rs7284616; rs7289611; rs7291028; rs9626816; rs9626823; rs9627278; rs9627280; rs9627281; rs9627287

# Macromolecular_Interacting_Partner_11_General_References:
7684926; 7981125; 8993548; 10591208; 9238002; 10681503

# Macromolecular_Interacting_Partner_11_References:
12611894; 15770421; 16296400; 16772437

End of HMDB00207